﻿FN Clarivate Analytics Web of Science
VR 1.0
PT J
AU Armborst, D
   Metzner, C
   Bitterlich, N
   Lemperle, M
   Siener, R
AF Armborst, Deborah
   Metzner, Christine
   Bitterlich, Norman
   Lemperle, Martin
   Siener, Roswitha
TI Effect of a weight-loss stabilization following a weight reduction with
   or without meal replacement on cardiometabolic risk in overweight women.
   A randomized controlled trial
SO INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION
LA English
DT Article
DE Weight-loss stabilization; weight reduction; abdominal obesity;
   cardiometabolic risk factors; weight management
ID METABOLICALLY HEALTHY OBESITY; HIGH-DENSITY-LIPOPROTEIN; LIFE-STYLE
   INTERVENTION; FATTY LIVER-DISEASE; HYPERTRIGLYCERIDEMIC-WAIST;
   CARDIOVASCULAR-DISEASE; BLOOD-PRESSURE; DIETARY-INTAKE; MENTAL STRESS;
   HEART-DISEASE
AB The objective of this study was to examine the effect of a 3-month weight-loss-stabilization phase (phase 2) following a successful 3-month weight-loss phase (phase 1), including a conventional energy-restricted diet with (MR) or without (C) meal replacement, on the cardiometabolic risk profile in 80 overweight women. In phase 2, both groups continued to significantly reduce weight and sustained the significant decreases in waist circumference and LDL-C. During the study, folic acid concentration significantly increased in the MR-group, while homocysteine concentration significantly worsened in the C-group. After 6 months, the number of women with hypertriglyceridemic waist was significantly reduced in both the groups, however with metabolic syndrome and metabolically unhealthy abdominal obesity (MUHAO) only in the MR-group. In conclusion, both strategies were equally effective for weight loss and weight-loss stabilization. The micronutrient supplementation with MR seemed to have an additional beneficial impact on the cardiometabolic risk in the MR-group versus the C-group.
C1 [Armborst, Deborah; Siener, Roswitha] Univ Bonn, Dept Urol, Med Nutr Sci, Sigmund Freud Str 25, D-53105 Bonn, Germany.
   [Metzner, Christine] Rhein Westfal TH Aachen, Univ Hosp, Dept Internal Med 3, Aachen, Germany.
   [Metzner, Christine] Bonn Educ Assoc Dietet RA, Cologne, Germany.
   [Bitterlich, Norman] Dept Biostat Med & Serv Ltd, Chemnitz, Germany.
   [Lemperle, Martin] Outpatient Ctr Nutr Educ, Frankfurt, Germany.
C3 University of Bonn; RWTH Aachen University; RWTH Aachen University
   Hospital
RP Armborst, D (corresponding author), Univ Bonn, Dept Urol, Med Nutr Sci, Sigmund Freud Str 25, D-53105 Bonn, Germany.
EM s7dearmb@uni-bonn.de
FU FormMed HealthCare AG, Frankfurt, Germany
FX The meal replacement products were provided free of charge from FormMed
   HealthCare AG, Frankfurt, Germany, which supported this work in part by
   a research grant.
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NR 82
TC 5
Z9 5
U1 0
U2 12
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0963-7486
EI 1465-3478
J9 INT J FOOD SCI NUTR
JI Int. J. Food Sci. Nutr.
PD MAY 19
PY 2019
VL 70
IS 4
BP 453
EP 466
DI 10.1080/09637486.2018.1537363
PG 14
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA HW1JG
UT WOS:000466438600009
PM 30621476
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Chuang, JC
   Cui, HX
   Mason, BL
   Mahgoub, M
   Bookout, AL
   Yu, HG
   Perello, M
   Elmquist, JK
   Repa, JJ
   Zigman, JM
   Lutter, M
AF Chuang, Jen-Chieh
   Cui, Huxing
   Mason, Brittany L.
   Mahgoub, Melissa
   Bookout, Angie L.
   Yu, Hana G.
   Perello, Mario
   Elmquist, Joel K.
   Repa, Joyce J.
   Zigman, Jeffrey M.
   Lutter, Michael
TI Chronic social defeat stress disrupts regulation of lipid synthesis
SO JOURNAL OF LIPID RESEARCH
LA English
DT Article
DE anxiety; cholesterol; depression feeding; liver
ID METABOLIC SYNDROME; LIPOPROTEIN RECEPTOR; LDL-RECEPTOR; MAJOR
   DEPRESSION; EXCESS MORTALITY; MOUSE-LIVER; CHOLESTEROL; DISORDER;
   PROTEIN; EXPRESSION
AB Several psychiatric disorders increase the risk of cardiovascular disease, including posttraumatic stress disorder and major depression. While the precise mechanism for this association has not yet been established, it has been shown that certain disorders promote an unfavorable lipid profile. To study the interaction of stress and lipid dysregulation, we utilized chronic social defeat stress (CSDS), a mouse model of chronic stress with features of posttraumatic stress disorder and major depression. Following exposure to CSDS, mice were given access to either regular chow or a Western-style diet high in fat and cholesterol (HFD). The combination of social stress and HFD resulted in significant perturbations in lipid regulation, including two key features of the metabolic syndrome: increased plasma levels of non-HDL cholesterol and intrahepatic accumulation of triglycerides. These effects were accompanied by a number of changes in the expression of hepatic genes involved in lipid regulation. Transcriptional activity of LXR, SREBP1c, and ChREBP were significantly affected by exposure to HFD and CSDS. We present CSDS as a model of social stress induced lipid dysregulation and propose that social stress alters lipid metabolism by increasing transcriptional activity of genes involved in lipid synthesis.-Chuang, J-C., H. Cui, B. L. Mason, M. Mahgoub, A. L. Bookout, H. G. Yu, M. Perello, J. K. Elmquist, J. J. Repa, J. M. Zigman, and M. Lutter. Chronic social defeat stress disrupts regulation of lipid synthesis. J. Lipid Res. 2010. 51: 1344-1353.
C1 [Chuang, Jen-Chieh; Cui, Huxing; Bookout, Angie L.; Perello, Mario; Elmquist, Joel K.; Repa, Joyce J.; Zigman, Jeffrey M.; Lutter, Michael] Univ Texas SW Med Ctr Dallas, Dept Internal Med, Div Hypothalam Res, Dallas, TX 75390 USA.
   [Cui, Huxing; Mason, Brittany L.; Mahgoub, Melissa; Yu, Hana G.; Elmquist, Joel K.; Zigman, Jeffrey M.; Lutter, Michael] Univ Texas SW Med Ctr Dallas, Dept Psychiat, Dallas, TX 75390 USA.
   [Repa, Joyce J.] Univ Texas SW Med Ctr Dallas, Dept Physiol, Dallas, TX 75390 USA.
   [Bookout, Angie L.; Elmquist, Joel K.] Univ Texas SW Med Ctr Dallas, Dept Pharmacol, Dallas, TX 75390 USA.
C3 University of Texas System; University of Texas Southwestern Medical
   Center Dallas; University of Texas System; University of Texas
   Southwestern Medical Center Dallas; University of Texas System;
   University of Texas Southwestern Medical Center Dallas; University of
   Texas System; University of Texas Southwestern Medical Center Dallas
RP Lutter, M (corresponding author), Univ Texas SW Med Ctr Dallas, Dept Internal Med, Div Hypothalam Res, Dallas, TX 75390 USA.
EM Michael.Lutter@UTSouthwestern.edu
RI Mason, Brittany/AAN-6360-2021
OI Zigman, Jeffrey/0000-0003-3477-1295; Repa, Joyce/0000-0001-5740-1954;
   Mason, Brittany/0000-0003-1832-1104; Cui, Huxing/0000-0002-8627-8534
FU NARSAD; Physician Scientist Training Program; Disease Oriented Clinical
   Scholars Program; Klarman Family Foundation;  [K08 MH084058-1A1]; 
   [1RL1DK081185-01];  [1PL1DK081182-01];  [8-UL1-DE019584-02];  [R37
   DK53301];  [R01DK071320];  [RL1 DK081182];  [UL1 RR024923];  [RL1
   DK081185];  [K08 DK068069-01A2]
FX This work was supported by the following grants: K08 MH084058-1A1,
   1RL1DK081185-01, 1PL1DK081182-01, 8-UL1-DE019584-02, R37 DK53301;
   R01DK071320, RL1 DK081182, UL1 RR024923, RL1 DK081185, K08
   DK068069-01A2; the NARSAD Young Investigator Award; the Physician
   Scientist Training Program; the Disease Oriented Clinical Scholars
   Program; and the Klarman Family Foundation. Its contents are solely the
   responsibility of the authors and do not necessarily represent the
   official views of the National Institutes of Health or other granting
   agencies.
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NR 41
TC 97
Z9 107
U1 0
U2 11
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0022-2275
EI 1539-7262
J9 J LIPID RES
JI J. Lipid Res.
PD JUN
PY 2010
VL 51
IS 6
BP 1344
EP 1353
DI 10.1194/jlr.M002196
PG 10
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 594UP
UT WOS:000277564700009
PM 20129912
OA Green Published
DA 2025-06-11
ER

PT J
AU Rashidkhani, B
   Gargari, BP
   Ranjbar, F
   Zareiy, S
   Kargarnovin, Z
AF Rashidkhani, Bahram
   Gargari, Bahram Pourghassem
   Ranjbar, Fatemeh
   Zareiy, Sanaz
   Kargarnovin, Zahra
TI Dietary patterns and anthropometric indices among Iranian women with
   major depressive disorder
SO PSYCHIATRY RESEARCH
LA English
DT Article
DE Nutrition; Factor analysis; Weight; Body Mass Index
ID BODY-MASS INDEX; METABOLIC SYNDROME; JOLLY FAT; ASSOCIATION; OBESITY;
   SYMPTOMS; PREVALENCE; OVERWEIGHT; RISK; FISH
AB Major depression is a common mental disorder among women. A number of studies have demonstrated the association between some nutrients and food items with depression, but the studies on the association of dietary patterns with depression, especially in the Middle East, are rare. Further, the literature examining the relationship between anthropometric status and depression are inconsistent. In this study, 45 women with major depression and 90 patients with no mental disorder participated. We collected dietary intakes by a semi-quantitative food frequency questionnaire, and measured anthropometric indices (weight, height, waist and hip circumferences). Using factor analysis, two major dietary patterns were extracted: Healthy and Unhealthy. After adjusting for confounders, individuals who gained higher scores in healthy dietary pattern, had 84% lower odds of major depression; while the odds of major depression in participants who gained higher scores in unhealthy dietary pattern showed no significant association. No significant association was found between anthropometric indices and major depression. These results suggest that the healthy dietary pattern is significantly associated with lower odds of major depression in adult women. Further researches are needed to confirm these findings. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
C1 [Rashidkhani, Bahram; Zareiy, Sanaz; Kargarnovin, Zahra] Shahid Beheshti Univ Med Sci, Fac Nutr Sci & Food Technol, Natl Nutr & Food Technol Res Inst, Dept Community Nutr, Tehran, Iran.
   [Gargari, Bahram Pourghassem] Tabriz Univ Med Sci, Fac Hlth & Nutr, Nutr Res Ctr, Dept Biochem & Diet Therapy, Tabriz, Iran.
   [Ranjbar, Fatemeh] Tabriz Univ Med Sci, Dept Psychiat, Fac Med, Tabriz, Iran.
C3 Shahid Beheshti University Medical Sciences; Tabriz University of
   Medical Science; Tabriz University of Medical Science
RP Kargarnovin, Z (corresponding author), Shahid Beheshti Univ Med Sci, Fac Nutr Sci & Food Technol, Natl Nutr & Food Technol Res Inst, Dept Community Nutr, Tehran, Iran.
EM zknovin@hotmail.com
RI rashidkhani, bahram/ABG-9304-2021; Ranjbar, Fatemeh/AAN-9550-2020;
   Pourghassem Gargari, Bahram/D-3556-2017
OI Pourghassem Gargari, Bahram/0000-0001-7667-099X
FU National Nutrition and Food Technology Research Institute (NNFTRI) of
   Iran
FX The present study was supported by a grant from the National Nutrition
   and Food Technology Research Institute (NNFTRI) of Iran, and we are
   grateful for their help. The authors appreciate Dr. Hadi Tabibi for his
   valuable help in designing the study.
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NR 50
TC 38
Z9 41
U1 0
U2 11
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0165-1781
EI 1872-7123
J9 PSYCHIAT RES
JI Psychiatry Res.
PD NOV 30
PY 2013
VL 210
IS 1
BP 115
EP 120
DI 10.1016/j.psychres.2013.05.022
PG 6
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 250NL
UT WOS:000326859400018
PM 23806625
DA 2025-06-11
ER

PT J
AU Zák, A
   Tvrzická, E
   Vecka, M
   Jáchymova, M
   Duffková, L
   Stanková, B
   Vávrová, L
   Kodydková, J
   Zeman, M
AF Zak, Ale
   Tvrzicka, Eva
   Vecka, Marek
   Jachymova, Marie
   Duffkova, Ladislava
   Stankova, Barbora
   Vavrova, Lucie
   Kodydkova, Jana
   Zeman, Miroslev
TI Severity of metabolic syndrome unfavorably influences oxidative stress
   and fatty acid metabolism in men
SO TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE
LA English
DT Article
DE metabolic syndrome components; fatty acid composition; oxidative stress
ID INSULIN-RESISTANCE SYNDROME; CARDIOVASCULAR RISK-FACTORS; FASTING
   PLASMA-GLUCOSE; BETA-CELL FUNCTION; MIDDLE-AGED MEN; APOLIPOPROTEIN-E;
   SERUM-LIPIDS; DIETARY-FAT; DENSITY-LIPOPROTEIN; BINDING PROTEIN
AB Metabolic syndrome (MS) is defined by the clustering of several components (MSC), which include abdominal fat accumulation, impaired glucose homeostasis, hypertriglyceridemia, lowered high-density lipoprotein cholesterol, increased blood pressure, and hyperuricemia. Metabolic syndrome is also accompanied by increased oxidative stress and inflammation as well as by altered composition of esterified fatty acids (FA). Therefore, we have investigated 210 men (categorized into six groups with increasing number of MSC) to find trends in the extent of oxidative stress, FA pattern and frequency of pathological alleles of the selected candidate genes for lipid metabolism. Increasing number of MSC was connected with the raised serum glucose and insulin, increased concentrations of conjugated dienes in low-density lipoprotein (all p < 0.0001), and high frequency of e2 and e4 alleles of the apolipoprotein E gene (p < 0.005). However, the last significance was lost after the adjustment for age. The incidence of 54Thr allele for intestinal isoform of the fatty acid-binding protein (FABP-2) gene was comparable in all groups. The most important findings were the raised content of saturated FA and the increased activities of Delta 9 and Delta 6 desaturases (all p < 0.0001), and the decreased content of polyunsaturated FA n-6 family and the decreased activity of A 5 desaturase (both p < 0.001) in connection with increasing number of MSC. In conclusion, the severity of MS is connected with the progression of oxidative stress and the unfavorable changes in the FA composition. These changes are independent of the studied gene polymorphisms.
C1 Charles Univ Prague, Dept Internal Med 4, Fac Med 1, Prague, Czech Republic.
   Charles Univ Prague, Inst Clin Biochem & Lab Diagnost, Fac Med 1, Prague, Czech Republic.
C3 Charles University Prague; Charles University Prague
RP Zák, A (corresponding author), Dept Med 4, U Nemocnice 2, Prague 12808 2, Czech Republic.
EM azak@vfn.cz
RI Vavrova, Lucie/D-7030-2017; Zak, Ales/G-8318-2016; Rychlikova,
   Jana/A-2531-2015; Vecka, Marek/A-3560-2008; Tvrzicka, Eva/Q-6300-2016;
   Zeman, Miroslav/J-5281-2016; Stankova, Barbora/L-7933-2016
OI Zak, Ales/0000-0002-1698-6068; Rychlikova, Jana/0000-0002-6961-5260;
   Vecka, Marek/0000-0002-3269-1817; Tvrzicka, Eva/0000-0003-0794-8454;
   Zeman, Miroslav/0000-0001-5338-603X; Stankova,
   Barbora/0000-0002-6184-4878
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NR 62
TC 23
Z9 27
U1 0
U2 8
PU TOHOKU UNIV MEDICAL PRESS
PI SENDAI
PA 2-1, SEIRYO-MACHI, AOBA-KU, SENDAI, MIYAGI 980-8575, JAPAN
SN 0040-8727
EI 1349-3329
J9 TOHOKU J EXP MED
JI Tohoku J. Exp. Med.
PD AUG
PY 2007
VL 212
IS 4
BP 359
EP 371
DI 10.1620/tjem.212.359
PG 13
WC Medicine, General & Internal; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Research & Experimental Medicine
GA 197AX
UT WOS:000248526500003
PM 17660701
OA Bronze
DA 2025-06-11
ER

PT J
AU Shartle, K
   Yang, YC
   Richman, LS
   Belsky, DW
   Aiello, AE
   Harris, KM
AF Shartle, Kaitlin
   Yang, Yang Claire
   Richman, Laura S.
   Belsky, Daniel W.
   Aiello, Allison E.
   Harris, Kathleen Mullan
TI Social Relationships, Wealth, and Cardiometabolic Risk: Evidence from a
   National Longitudinal Study of US Older Adults
SO JOURNAL OF AGING AND HEALTH
LA English
DT Article
DE social relationships; cardiometabolic risk; wealth; trajectories; older
   adults
ID METABOLIC SYNDROME; CARDIOVASCULAR-DISEASE; SOCIOECONOMIC-STATUS;
   FUNDAMENTAL CAUSES; HEALTH; MORTALITY; AGE; INTEGRATION; INDICATORS
AB Objectives: To investigate multiple dimensions of social relationships related to biomarkers of cardiometabolic health and how their associations vary by wealth in older adults. Methods: Growth curve models were used to investigate the longitudinal associations between measures of both positive and negative social relationships and cardiometabolic risk (CMR) over a 10-year period from 2006 to 2016 and the moderation of this association by wealth in the Health and Retirement Study (HRS). Results: Older adults with better social relationships had lower CMR on average. The protective effects of positive social relationships, however, waned at older ages, particularly for low-wealth individuals. Discussion: Our results suggest that good social relationships promote healthy aging by buffering against harmful cardiometabolic consequences of psychosocial stress, particularly among relatively wealthy individuals. Efforts to improve old age health would be more effective when focusing simultaneously on fostering social connections and boosting financial resources.
C1 [Shartle, Kaitlin; Yang, Yang Claire; Harris, Kathleen Mullan] Univ N Carolina, Dept Sociol, 155 Pauli Murray Hall, Chapel Hill, NC 27599 USA.
   [Shartle, Kaitlin; Yang, Yang Claire; Aiello, Allison E.; Harris, Kathleen Mullan] Univ N Carolina, Carolina Populat Ctr, Chapel Hill, NC 27599 USA.
   [Yang, Yang Claire] Univ N Carolina, Sch Med, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA.
   [Richman, Laura S.] Duke Univ, Sch Med, Durham, NC USA.
   [Belsky, Daniel W.] Columbia Univ, Mailman Sch Publ Hlth, Dept Epidemiol, New York, NY USA.
   [Aiello, Allison E.] Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Epidemiol, Chapel Hill, NC USA.
C3 University of North Carolina; University of North Carolina Chapel Hill;
   University of North Carolina; University of North Carolina Chapel Hill;
   University of North Carolina; University of North Carolina Chapel Hill;
   University of North Carolina School of Medicine; Duke University;
   Columbia University; University of North Carolina; University of North
   Carolina Chapel Hill
RP Shartle, K (corresponding author), Univ N Carolina, Dept Sociol, 155 Pauli Murray Hall, Chapel Hill, NC 27599 USA.
EM ksharde@live.unc.edu
RI Belsky, Daniel/HDN-5118-2022
OI Richman, Laura/0000-0002-1381-851X; Shartle,
   Kaitlin/0000-0001-7266-6694; Aiello, Allison/0000-0001-7029-2537
FU NIH [R01 AG057800, R24 HD050924]; University Cancer Research Funds;
   National Institute on Aging [NIA U01AG009740]; National Institute on
   Aging; Social Security Administration; National Institute on Aging
   [U01AG009740, R01AG057800] Funding Source: NIH RePORTER
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: This
   research is supported by NIH grants to Yang (R01 AG057800) and to the
   Carolina Population Center for research support (R24 HD050924); and also
   supported by the University Cancer Research Funds to Yang at the
   Lineberger Cancer Center. The HRS (Health and Retirement Study) is
   sponsored by the National Institute on Aging (grant number NIA
   U01AG009740) and is conducted by the University of Michigan. RAND HRS
   Longitudinal File 2016 (V2). Produced by the RAND Center for the Study
   of Aging, with funding from the National Institute on Aging and the
   Social Security Administration. Santa Monica, CA (2020).
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NR 50
TC 6
Z9 7
U1 0
U2 6
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0898-2643
EI 1552-6887
J9 J AGING HEALTH
JI J. Aging Health
PD OCT
PY 2022
VL 34
IS 6-8
BP 1048
EP 1061
AR 08982643221087807
DI 10.1177/08982643221087807
EA APR 2022
PG 14
WC Gerontology; Health Policy & Services
WE Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Health Care Sciences & Services
GA 4O7MS
UT WOS:000788410100001
PM 35481380
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Jiao, JT
   Jiang, C
   Huang, J
   Dai, MC
   Wang, C
   Cheng, C
   Shao, JF
AF Jiao, Jian-tong
   Jiang, Chen
   Huang, Jin
   Dai, Min-chao
   Wang, Cheng
   Cheng, Chao
   Shao, Jun-fei
TI RETRACTED: Metabolic syndrome factors and risk of postoperative
   depression in high-grade glioma patients in a 1.5-year prospective study
   (Retracted article. See vol. 34, art no 11, 2014)
SO MEDICAL ONCOLOGY
LA English
DT Article; Retracted Publication
DE High-grade glioma; Postoperative depression; Metabolic syndrome factors;
   Blood glucose
ID CANCER-PATIENTS; NERVOUS-SYSTEM; ENERGY-BALANCE; IMMUNE-SYSTEM;
   BRAIN-TUMORS; YOUNG-ADULTS; INSULIN; HYPERTENSION; COHORT; ASSOCIATION
AB To date, the relationship between metabolic syndrome factors and the risk of glioma-related depression is still unclear, and no study investigates this relationship. Our aim was to investigate the relationship between metabolic syndrome factors and the risk of postoperative depression in high-grade patients. A total of 386 high-grade glioma patients participated in blood sample collection for metabolic syndrome factors analysis and the hospital anxiety and depression scale testing. The association between metabolic syndrome factors and the risk of postoperative depression was assessed using Cox regression proportional hazards models, and Student's t tests were used to evaluate the differences in demographic variables and clinical characteristics in subgroups. The incidence of postoperative depression in our 1.5-year follow-up was 30.5 %. We found the risk of postoperative depression was elevated with increased blood glucose level [hazard ratios (HR) 2.277, 95 % confidence interval (CI) 1.201-4.320, top vs. bottom quartile]. The hazard ratio was increased for z-scores of blood glucose (HR 1.672 per unit standard deviation, 95 % CI 1.311-2.133] and of the combined metabolic syndrome score (HR 1.080, 95 % CI 1.000-1.167). In addition, risk of postoperative depression risk was increased in high-grade glioma patients with high blood glucose levels (>= 6.0 mmol/l) (HR 2.084, 95 % CI 1.235-3.515). However, we did not find significant associations between postoperative depression and other metabolic syndrome factors, including body mass index, systolic blood pressure, diastolic blood pressure, cholesterol, and triglycerides. Depression is prevalent among patients with high-grade glioma after operation. Blood glucose level is positively associated with the risk of postoperative depression, and might be involved in the etiology of postoperative depression, and may predict its development in high-grade glioma patients.
C1 [Jiao, Jian-tong; Jiang, Chen; Huang, Jin; Dai, Min-chao; Wang, Cheng; Cheng, Chao; Shao, Jun-fei] Nanjing Med Univ, Wuxi Peoples Hosp, Dept Neurosurg, Wuxi 214023, Peoples R China.
C3 Nanjing Medical University; Jiangnan University
RP Shao, JF (corresponding author), Nanjing Med Univ, Wuxi Peoples Hosp, Dept Neurosurg, Wuxi 214023, Peoples R China.
EM tongjianjiao@126.com; wxhneurosurgery@126.com
RI Jiang, Chen/W-9403-2018; 程, 超/HCI-6356-2022; Chen, Wei/GZK-7348-2022;
   shao, jianfu/N-2447-2018
OI shao, jianfu/0000-0002-6632-8207
FU National Natural Science Foundation of China (NSFC) [81272791]
FX This work was supported by grants from the National Natural Science
   Foundation of China (NSFC, 81272791).
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NR 40
TC 8
Z9 9
U1 0
U2 12
PU HUMANA PRESS INC
PI TOTOWA
PA 999 RIVERVIEW DRIVE SUITE 208, TOTOWA, NJ 07512 USA
SN 1357-0560
EI 1559-131X
J9 MED ONCOL
JI Med. Oncol.
PD OCT
PY 2014
VL 31
IS 10
AR 234
DI 10.1007/s12032-014-0234-y
PG 8
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA AP4WG
UT WOS:000342079600049
PM 25223530
DA 2025-06-11
ER

PT J
AU Kahl, KG
   Greggersen, W
   Schweiger, U
   Cordes, J
   Balijepalli, C
   Lösch, C
   Moebus, S
AF Kahl, Kai G.
   Greggersen, Wiebke
   Schweiger, Ulrich
   Cordes, Joachim
   Balijepalli, Chakrapani
   Loesch, Christian
   Moebus, Susanne
TI Prevalence of the metabolic syndrome in unipolar major depression
SO EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
LA English
DT Article
DE Major depression; Metabolic syndrome; Physical health; Anxiety disorder
ID INSULIN-RESISTANCE; BIPOLAR-DISORDER; CARDIOVASCULAR-DISEASE;
   YOUNG-ADULTS; FOLLOW-UP; RISK; WOMEN; ASSOCIATION; SYMPTOMS; ANXIETY
AB Previous studies on the association between affective disorders and the metabolic syndrome yielded inconclusive results. Therefore, we examined the prevalence of the metabolic syndrome in 230 men and women with unipolar major depressive disorder during inpatient treatment and compared it to 1,673 subjects from primary care from a similar region in northern Germany. We used the AHA/NHBLI criteria to determine the rate of metabolic syndrome (MetS) and each single criterion of MetS in both groups. The age-standardized prevalence of MetS was 2.4x as high in patients with major depressive disorder (MDD) compared with data from comparison subjects (41.0% vs. 17.0%). With respect to the single criteria, elevations were found in MDD patients for fasting glucose and triglycerides in both genders, and waist circumference in women. Men in the patient and the comparison groups were found to have higher rates of increased fasting glucose and triglycerides than women in the respective groups. Factors associated with the MetS in MDD patients comprise body mass index and the severity of depression. Our results demonstrate an increased prevalence of the MetS in men and women with MDD. Interventions for the frequently untreated metabolic abnormalities and careful screening for physical health conditions among people with MDD are warranted.
C1 [Kahl, Kai G.] Hannover Med Sch, Dept Psychiat Social Psychiat & Psychotherapy, D-30625 Hannover, Germany.
   [Greggersen, Wiebke; Schweiger, Ulrich] Luebeck Med Sch, Dept Psychiat & Psychotherapy, Lubeck, Germany.
   [Cordes, Joachim] Univ Dusseldorf, Dept Psychiat & Psychotherapy, D-40225 Dusseldorf, Germany.
   [Balijepalli, Chakrapani; Loesch, Christian; Moebus, Susanne] Univ Duisburg Essen, Univ Hosp Essen, Inst Med Informat Biometry & Epidemiol, Essen, Germany.
C3 Hannover Medical School; Heinrich Heine University Dusseldorf;
   University of Duisburg Essen
RP Kahl, KG (corresponding author), Hannover Med Sch, Dept Psychiat Social Psychiat & Psychotherapy, Carl Neuberg Str 1, D-30625 Hannover, Germany.
EM Kahl.Kai@mh-hannover.de
OI Moebus, Susanne/0000-0002-0072-5410
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NR 49
TC 60
Z9 62
U1 0
U2 13
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0940-1334
EI 1433-8491
J9 EUR ARCH PSY CLIN N
JI Eur. Arch. Psych. Clin. Neurosci.
PD JUN
PY 2012
VL 262
IS 4
BP 313
EP 320
DI 10.1007/s00406-011-0277-4
PG 8
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Psychiatry
GA 952TM
UT WOS:000304815300005
PM 22183567
DA 2025-06-11
ER

PT J
AU Johnson, CC
   Sheffield, KM
   Brown, RE
AF Johnson, Candace C.
   Sheffield, Karen M.
   Brown, Roy E.
TI Mind-Body Therapies for African-American Women at Risk for
   Cardiometabolic Disease: A Systematic Review
SO EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Review
ID METABOLIC SYNDROME; PHYSICAL-ACTIVITY; US ADULTS; HEART-DISEASE;
   PREVALENCE; STRESS; MANAGEMENT; HEALTH; INTERVENTION; OBESITY
AB Background. A major determinant in cardiometabolic health is metabolic syndrome (MetS), a cluster of symptoms that portend the development of cardiovascular disease (CVD). As mind-body therapies are thought to help in lowering physiological and environmental CVD risk factors including blood pressure and psychological stress, they may also be beneficial for the primary prevention of CVD. Objectives. To synthesize and summarize existing knowledge on the effectiveness of mind-body therapies on MetS outcomes in African-American (AA) women, a US subpopulation at high risk for CVD. Search Methods. A systematic search of eight databases was conducted in order to identify published papers addressing the topic. We included trials involving AA adult women, ages 18-64, and we included RCTs that involved multifactorial interventions. Outcomes of interest were MetS, chronic disease, and CVD risk factors (blood pressure, blood lipids, blood glucose, BMI, waist circumference, and mental health domains). Two authors independently selected trials for inclusion, extracted data, and assessed risks of bias. Main Results. We identified five trials for inclusion in this review. One study reported outcomes associated with the full MetS symptom cluster. The included trials were small, short term, and at high risk of bias. All interventions lasted at least 6 weeks.
C1 [Johnson, Candace C.] Virginia Commonwealth Univ, Sch Nursing, Dept Family & Community Hlth Nursing, 1100 E Leigh St,POB 980567, Richmond, VA 23298 USA.
   [Sheffield, Karen M.] Univ N Carolina, Chapel Hill Sch Nursing, 307 E Carrington Hall,Campus Box 7460, Chapel Hill, NC 27599 USA.
   [Brown, Roy E.] Virginia Commonwealth Univ, Sch Nursing, Tompkins McCaw Lib Hlth Sci, 509 N 12th St,POB 980582, Richmond, VA 23298 USA.
C3 Virginia Commonwealth University; University of North Carolina;
   University of North Carolina Chapel Hill; Virginia Commonwealth
   University
RP Johnson, CC (corresponding author), Virginia Commonwealth Univ, Sch Nursing, Dept Family & Community Hlth Nursing, 1100 E Leigh St,POB 980567, Richmond, VA 23298 USA.
EM johnsoncm7@vcu.edu
RI Brown, Roy/J-5428-2019
FU National Institute of Nursing Research [T32NR007091]; Virginia
   Commonwealth University School of Nursing
FX Ms. Sheffield received financial support from the National Institute of
   Nursing Research under Award no. T32NR007091 (MPIs: S. Santacroce, J.
   Leeman). Dr. Johnson received financial support from an internal grant
   at Virginia Commonwealth University School of Nursing.
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NR 46
TC 6
Z9 6
U1 0
U2 3
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1741-427X
EI 1741-4288
J9 EVID-BASED COMPL ALT
JI Evid.-based Complement Altern. Med.
PY 2018
VL 2018
AR 5123217
DI 10.1155/2018/5123217
PG 11
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Integrative & Complementary Medicine
GA FY9JB
UT WOS:000427180600001
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Hulteen, RM
   Marlatt, KL
   Allerton, TD
   Lovre, D
AF Hulteen, Ryan M. M.
   Marlatt, Kara L. L.
   Allerton, Timothy D. D.
   Lovre, Dragana
TI Detrimental Changes in Health during Menopause: The Role of Physical
   Activity
SO INTERNATIONAL JOURNAL OF SPORTS MEDICINE
LA English
DT Review
DE menopause; physical activity; exercise; metabolism; adiposity; insulin
   resistance
ID BONE-MINERAL DENSITY; HABITUAL AEROBIC EXERCISE; NITRIC-OXIDE
   PRODUCTION; POSTMENOPAUSAL WOMEN; WEIGHT-LOSS; MIDLIFE WOMEN;
   ENDOTHELIAL FUNCTION; INSULIN SENSITIVITY; ENERGY-EXPENDITURE;
   BODY-COMPOSITION
AB Midlife women experience changes in cardiometabolic, physical, and psychosocial health during menopause that negatively impacts their overall quality of life. Factors that contribute to these increases in cardiometabolic risk include weight gain as well as increases in fat mass (particularly abdominal adiposity), insulin resistance, and vascular dysfunction. Other deleterious changes in physical health (e. g. reduced sleep health, bone density, and balance) as well as changes in psychosocial health (e. g. mood, anxiety, and depression) often coincide and are linked to these increases in cardiometabolic risk. Physical activity and exercise are important lifestyle components that have been demonstrated to improve cardiometabolic, physical, and psychosocial health, yet physical activity and exercise is known to decline during perimenopause and into the postmenopausal years. In this narrative review, we summarize these changes in overall health during menopause as well as how declining physical activity contributes to these changes. Additionally, we discuss how incorporating physical activity and exercise during menopause can potentially ameliorate health declines. We conclude that there exists a significant, positive impact of physical activity on cardiometabolic, physical, and psychological health among midlife women, particularly if undertaken during the perimenopausal and postmenopausal years.
C1 [Hulteen, Ryan M. M.] Louisiana State Univ, Kinesiol, 2229 Pleasant Hall, Baton Rouge, LA 70809 USA.
   [Marlatt, Kara L. L.] Pennington Biomed Res Ctr, Clin Sci, Baton Rouge, LA USA.
   [Allerton, Timothy D. D.] Pennington Biomed Res Ctr, Basic Sci, Baton Rouge, LA USA.
   [Lovre, Dragana] Tulane Univ Hlth Sci Ctr, Sch Med, New Orleans, LA USA.
   [Lovre, Dragana] Southeast Louisiana Vet Hlth Care Syst, Medicine, New Orleans, LA USA.
C3 Louisiana State University System; Louisiana State University; Louisiana
   State University System; Louisiana State University; Pennington
   Biomedical Research Center; Louisiana State University System; Louisiana
   State University; Pennington Biomedical Research Center; Tulane
   University; Tulane University Hospital
RP Hulteen, RM (corresponding author), Louisiana State Univ, Kinesiol, 2229 Pleasant Hall, Baton Rouge, LA 70809 USA.
RI Hulteen, Ryan/AFK-7703-2022; Lovre, Dragana/AAA-1832-2020
FU National Institute of General Medical Sciences; Biomedical Laboratory
   Research and Development, VA Office of Research and Development [P30
   GM118430]; National Institute of Diabetes and Digestive and Kidney
   Diseases [IK2 CX002225]
FX National Institute of General Medical Sciences -
   http://dx.doi.org/10.13039/100000057; P30 GM118430 Biomedical Laboratory
   Research and Development, VA Office of Research and Development -
   http://dx.doi.org/10.13039/100007496; IK2 CX002225 National Institute of
   Diabetes and Digestive and Kidney Diseases -
   http://dx.doi.org/10.13039/100000062; K01 DK128227
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NR 112
TC 15
Z9 15
U1 11
U2 40
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0172-4622
EI 1439-3964
J9 INT J SPORTS MED
JI Int. J. Sports Med.
PD JUN
PY 2023
VL 44
IS 06
BP 389
EP 396
DI 10.1055/a-2003-9406
EA FEB 2023
PG 8
WC Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Sport Sciences
GA H7DO0
UT WOS:000936123600003
PM 36807278
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Vogelzangs, N
   Suthers, K
   Ferrucci, L
   Simonsick, EM
   Ble, A
   Schrager, M
   Bandinelli, S
   Lauretani, F
   Giannelli, SV
   Penninx, BW
AF Vogelzangs, Nicole
   Suthers, Kristen
   Ferrucci, Luigi
   Simonsick, Eleanor M.
   Ble, Alessandro
   Schrager, Matthew
   Bandinelli, Stefania
   Lauretani, Fulvio
   Giannelli, Sandra V.
   Penninx, Brenda W.
TI Hypercortisolemic depression is associated with the metabolic syndrome
   in late-life
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE depression; cortisol; HPA-axis; metabolic syndrome; older persons
ID 3RD NATIONAL-HEALTH; INSULIN-RESISTANCE; MAJOR DEPRESSION; PSYCHOLOGICAL
   RISK; STRESS; SYMPTOMS; CORTISOL; HEART; MOOD; MORTALITY
AB Introduction: Depression has been hypothesized to be associated with metabolic abnormalities which increase the risk of cardiovascular disease (CVD) and diabetes. Such a link could be due to increased HPA-axis activity. This study investigates the cross-sectional relationship between depression, urinary cortisol and metabolic syndrome in an older population.
   Methods: Data are from 867 participants of the InChianti Study, aged >=,65 years. Depressive symptoms were assessed using the CES-D scale; cortisol levels were determined in 24-h urine samples. Metabolic syndrome was defined as three or more of the following: abdominal obesity, high triglycerides, tow HDL cholesterol, high blood pressure, and high fasting glucose.
   Results: Clinically relevant depressed mood (CES-D >= 20) was present in 20.6% of the sample, and 24.5% had the metabolic syndrome. After adjustment for sociodemographics and health indicators, depression score (per SD increase: OR = 1.20, 95% Cl = 1.02-1.41) and urinary cortisot level (per SD increase: OR = 1.23, 95% Cl = 1.01-1.51) were significantly associated with presence of metabolic syndrome. There was, however, a significant interaction (p = 0.003) between depressed mood and urinary cortisot in the probability of having metabolic syndrome. The odds of metabolic syndrome in persons with both depressed mood and urinary cortisot excretion in the highest tertile was 1.84 (95% Cl = 1.02-3.34) compared to persons with neither condition.
   Discussion: This study suggests a synergistic relationship between depression, cortisol and metabolic syndrome. Hypercortisolemic depression may constitute a specific risk group for the metabolic syndrome. (c) 2006 Elsevier Ltd. All rights reserved.
C1 Vrije Univ Amsterdam, Med Ctr, Dept Psychiat, NL-1081 HJ Amsterdam, Netherlands.
   Vrije Univ Amsterdam, Med Ctr, EMGO Inst, NL-1081 HJ Amsterdam, Netherlands.
   NIA, Clin Res Branch, Baltimore, MD 21224 USA.
   ASF, Florence, Italy.
   Tuscany Hlth Reg Agcy, Florence, Italy.
   NIA, Dept Epidemiol, Bethesda, MD 20892 USA.
   Univ Hosp Geneva, Dept Rehabil & Geriatr, Geneva, Switzerland.
C3 Vrije Universiteit Amsterdam; Vrije Universiteit Amsterdam; National
   Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA);
   National Institutes of Health (NIH) - USA; NIH National Institute on
   Aging (NIA); University of Geneva
RP Vogelzangs, N (corresponding author), Vrije Univ Amsterdam, Med Ctr, Dept Psychiat, Oldenaller 1, NL-1081 HJ Amsterdam, Netherlands.
EM nicolev@ggzba.nl
RI Ferrucci, Luigi/AED-9724-2022; Penninx, Brenda/S-7627-2017; Ble,
   Alessandro/AAV-5747-2020; bandinelli, stefania/AAL-4570-2020; Giannelli,
   Sandra/E-8637-2011; Simonsick, Eleanor/W-6864-2019; Lauretani,
   Fulvio/K-5115-2016
OI Bandinelli, Stefania/0000-0002-6491-0850; Ferrucci,
   Luigi/0000-0002-6273-1613; Lauretani, Fulvio/0000-0002-5287-9972
FU NHLBI NIH HHS [R01 HL72972-01, R01 HL072972] Funding Source: Medline;
   PHS HHS [IRTA 2300 320 7] Funding Source: Medline; Intramural NIH HHS
   [Z99 AG999999] Funding Source: Medline
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NR 44
TC 177
Z9 186
U1 0
U2 13
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD FEB
PY 2007
VL 32
IS 2
BP 151
EP 159
DI 10.1016/j.psyneuen.2006.11.009
PG 9
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA 147FE
UT WOS:000244988000008
PM 17224244
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Yamamoto, K
   Okazaki, A
   Ohmori, S
AF Yamamoto, Kazuhiko
   Okazaki, Ai
   Ohmori, Susumu
TI The Relationship between Psychosocial Stress, Age, BMI, CRP, Lifestyle,
   and the Metabolic Syndrome in Apparently Healthy Subjects
SO JOURNAL OF PHYSIOLOGICAL ANTHROPOLOGY
LA English
DT Article
DE psychosocial stress; CRP; lifestyle; obesity; metabolic syndrome
ID C-REACTIVE PROTEIN; NUTRITION EXAMINATION SURVEY; INSULIN-RESISTANCE
   SYNDROME; TYPE-2 DIABETES-MELLITUS; CORONARY-HEART-DISEASE;
   PUBLIC-SCHOOL WORKERS; 3RD NATIONAL-HEALTH; ALCOHOL-CONSUMPTION;
   DEPRESSIVE SYMPTOMS; SEX-DIFFERENCES
AB The aim of this cross-sectional study was to examine the factors which may be associated with the metabolic syndrome by exploring the relationship between psychosocial stress, age, body mass index (HMI), C-reactive protein (CRP), lifestyle factors., and the components of the metabolic syndrome, such as glycated hemoglobin (HbA1c), fasting blood sugar (FBS), body fat percentage, and triglyceride concentration, among apparently healthy subjects. Psychosocial stress was measured by the use of the inventory to measure psychosocial stress (IMPS). One thousand four hundred and ninety-nine people out of 1,941 public school workers admitted to a hospital for a medical check-up responded to the IMPS, yielding a response rate of 77.2%. A total of 1,201 workers excluding 298 who were taking medication for various diseases were analyzed with the use of hierarchical multiple regression models. It was found that IMPS-measured stress score, age, BMI, and smoking habit were associated with an increase in glycated hemoglobin among men, while alcohol consumption was associated with a decrease in glycated hemoglobin. Stress score, age, BM1, and alcohol consumption were found to be associated with an increase in FBS among men, while smoking and exercise habits were associated with a decrease in FBS. CRP was found to be associated with an increase in body fat percentage among men, though stress score was not associated with an increase in body fat percentage. Stress score, age, and BMI were associated with an increase in triglyceride concentration among women. The findings of the present study seem to be in line with the hypothesis that psychosocial stress plays an important role in developing the metabolic syndrome, which may be associated with inflammatory processes in the vascular wall, resulting in atherosclerosis and cardiovascular disease. J Physiol Anthropol 30(1): 15-22, 2011 http://www.jstage.jst.go.jp/browse/jpa2 [DOI: 10.2114/jpa2.30.15]
C1 [Yamamoto, Kazuhiko] Kyushu Univ, Inst Hlth Sci, Minami Ku, Fukuoka 8158540, Japan.
   [Ohmori, Susumu] Kyushu Cent Hosp, Fukuoka, Japan.
C3 Kyushu University
RP Yamamoto, K (corresponding author), Kyushu Univ, Inst Hlth Sci, Minami Ku, Fukuoka 8158540, Japan.
EM yamamoto@design.kyushu-u.ac.jp
FU Japan Society for the Promotion of Science [16207018]; Grants-in-Aid for
   Scientific Research [16207018] Funding Source: KAKEN
FX This study was supported in part by a Grant-in-Aid for Scientific
   Research, No. 16207018, from the Japan Society for the Promotion of
   Science.
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NR 50
TC 37
Z9 46
U1 0
U2 15
PU JAPAN SOC PHYSIOLOGICAL ANTHROPOLOGY
PI TOKYO
PA BUSINESS CENTER FOR ACADEMIC SOCIETIES JAPAN, 5-16-9 HONKOMAGOME, TOKYO,
   00000, JAPAN
SN 1880-6791
J9 J PHYSIOL ANTHROPOL
JI J. Physiol. Anthropol.
PD JAN
PY 2011
VL 30
IS 1
BP 15
EP 22
DI 10.2114/jpa2.30.15
PG 8
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA 722JH
UT WOS:000287428000003
PM 21307616
OA Bronze
DA 2025-06-11
ER

PT J
AU McCaffery, JM
   Marsland, AL
   Strohacker, K
   Muldoon, MF
   Manuck, SB
AF McCaffery, Jeanne M.
   Marsland, Anna L.
   Strohacker, Kelley
   Muldoon, Matthew F.
   Manuck, Stephen B.
TI Factor Structure Underlying Components of Allostatic Load
SO PLOS ONE
LA English
DT Article
ID INSULIN-RESISTANCE SYNDROME; CORONARY-HEART-DISEASE; GENOME-WIDE
   ASSOCIATION; METABOLIC SYNDROME; INFLAMMATORY MARKERS; RATE-VARIABILITY;
   RISK-FACTORS; SYNDROME PREDICTS; LOCI; MACARTHUR
AB Allostatic load is a commonly used metric of health risk based on the hypothesis that recurrent exposure to environmental demands (e.g., stress) engenders a progressive dysregulation of multiple physiological systems. Prominent indicators of response to environmental challenges, such as stress-related hormones, sympatho-vagal balance, or inflammatory cytokines, comprise primary allostatic mediators. Secondary mediators reflect ensuing biological alterations that accumulate over time and confer risk for clinical disease but overlap substantially with a second metric of health risk, the metabolic syndrome. Whether allostatic load mediators covary and thus warrant treatment as a unitary construct remains to be established and, in particular, the relation of allostatic load parameters to the metabolic syndrome requires elucidation. Here, we employ confirmatory factor analysis to test: 1) whether a single common factor underlies variation in physiological systems associated with allostatic load; and 2) whether allostatic load parameters continue to load on a single common factor if a second factor representing the metabolic syndrome is also modeled. Participants were 645 adults from Allegheny County, PA (30-54 years old, 82% non- Hispanic white, 52% female) who were free of confounding medications. Model fitting supported a single, second-order factor underlying variance in the allostatic load components available in this study (metabolic, inflammatory and vagal measures). Further, this common factor reflecting covariation among allostatic load components persisted when a latent factor representing metabolic syndrome facets was conjointly modeled. Overall, this study provides novel evidence that the modeled allostatic load components do share common variance as hypothesized. Moreover, the common variance suggests the existence of statistical coherence above and beyond that attributable to the metabolic syndrome.
C1 [McCaffery, Jeanne M.; Strohacker, Kelley] Brown Univ, Dept Psychiat & Human Behav, Miriam Hosp, Providence, RI 02912 USA.
   [McCaffery, Jeanne M.; Strohacker, Kelley] Brown Univ, Warren Alpert Sch Med, Providence, RI 02912 USA.
   [Marsland, Anna L.] Univ Pittsburgh, Dept Psychol, Pittsburgh, PA 15260 USA.
   [Muldoon, Matthew F.] Univ Pittsburgh, Sch Med, Inst Heart & Vasc, Pittsburgh, PA USA.
   [Manuck, Stephen B.] Univ Pittsburgh, Dept Psychol, Pittsburgh, PA 15260 USA.
C3 Lifespan Health Rhode Island; Miriam Hospital; Brown University; Brown
   University; Pennsylvania Commonwealth System of Higher Education
   (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of
   Higher Education (PCSHE); University of Pittsburgh; Pennsylvania
   Commonwealth System of Higher Education (PCSHE); University of
   Pittsburgh
RP McCaffery, JM (corresponding author), Brown Univ, Dept Psychiat & Human Behav, Miriam Hosp, Providence, RI 02912 USA.
EM jeanne_mccaffery@brown.edu
OI McCaffery, Jeanne/0000-0002-2166-5840; Strohacker,
   Kelley/0000-0002-2067-8439
FU National Heart Lung and Blood Institute [P01HL40962]; National Institute
   of Nursing Research [NR008237]
FX This study was supported by grants P01HL40962 from the National Heart
   Lung and Blood Institute (SBM), and NR008237 from the National Institute
   of Nursing Research (ALM). The funders had no role in study design, data
   collection and analysis, decision to publish, or preparation of the
   manuscript.
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NR 58
TC 63
Z9 76
U1 0
U2 14
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD OCT 24
PY 2012
VL 7
IS 10
AR e47246
DI 10.1371/journal.pone.0047246
PG 8
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 026VC
UT WOS:000310310200031
PM 23112812
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Bu, DY
   Ji, WW
   Bai, D
   Zhou, J
   Li, HX
   Yang, HF
AF Bu, De-Yun
   Ji, Wen-Wu
   Bai, Dan
   Zhou, Jian
   Li, Hai-Xia
   Yang, Hui-Fang
TI Association of Polymorphisms in Stress-Related TNFα and NPY Genes with
   the Metabolic Syndrome in Han and Hui Ethnic Groups
SO ASIAN PACIFIC JOURNAL OF CANCER PREVENTION
LA English
DT Article
DE Metabolic syndrome; psychological stress; TNF alpha-308G/A; NPYrs16147;
   SCL; 90; Han and Hui ethnicity
ID NEUROPEPTIDE-Y; INSULIN-RESISTANCE; G-308A POLYMORPHISM; TNF-ALPHA-308
   G/A; INDUCED OBESITY; PROMOTER; EXPRESSION; RISK; INFLAMMATION; GENETICS
AB Background: Metabolic syndrome (MS) is a cluster of complicated disorders caused by the interactive influencing factors of heredity and environment, which predisposes to many cnacers. Results from epidemic research indicate that stress is tightly related to the pathogenesis of MS and neoplasia. This paper aims to investigate the association between psychological stress and MS with respect to the tumor necrosis factor alpha (TNF alpha) and neuropeptide Y (NPY) genes in the Han and Hui ethnic groups. Methods: All subjects for this case-control study matched strict enrollment criteria (nationality, gender and age) and lived in the city of Wu Zhong of Ningxia Province in China. The enrolled group contained 102 matched pairs of Hui ethnic individuals and 98 matched pairs of Han ethnic individuals. Enrolled subjects completed the general Symptom Checklist-90 (SCL-90). The TNF alpha-308G/A variant and NPYrs16147 polymorphism were detected in case (81 males, 119 females) and control (81 males, 119 females) groups by polymerase chain reaction (PCR) amplification. Results: Nine factors of the SCL-90 were found to be statistically different (p<0.05) between case and control groups. The homozygous mutant genotype (AA) and the mutant allele (A) of the TNF alpha-308G/A gene were less frequently observed in the control population compared to the case group. The odds ratio (95% confidence interval) in "Allele" for MS was 2.28 (1.47-3.53), p=0.0001, while "OR" was 1.11 (0.83-1.47), p=0.15, for the NPYrs16147 gene polymorphism. Conclusions: Psychological stress has been positively associated with MS. A previous study from our group suggested there were differences in the level of psychological stress between Hui and Han ethnic groups. Furthermore, we found that the stress-related TNF alpha gene was associated with MS for both Han and Hui ethnic groups. In contrast, NPY may be a possible contributor to MS and associated cancer for the Han ethnic group.
C1 [Bu, De-Yun; Ji, Wen-Wu; Bai, Dan; Zhou, Jian; Li, Hai-Xia; Yang, Hui-Fang] Ningxia Med Univ, Sch Publ Hlth, Yinchuan, Ningxia, Peoples R China.
C3 Ningxia Medical University
RP Yang, HF (corresponding author), Ningxia Med Univ, Sch Publ Hlth, Yinchuan, Ningxia, Peoples R China.
EM joyceyhf1968@gmail.com
FU State Natural Science Foundation of China [30860236]
FX This study was financially supported by the State Natural Science
   Foundation of China (no. 30860236). We thank Doctors Li Jun and Gao
   Xianghui of City Hospital of Wu Zhong for their administrative support
   during the execution of the study. We also thank Doctor Sun Jian of
   Yinchuan Center for Disease Control and Prevention, Ningxia, China, for
   his assistance in laboratory analysis.
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NR 49
TC 3
Z9 3
U1 0
U2 9
PU ASIAN PACIFIC ORGANIZATION CANCER PREVENTION
PI GYEONGGI-DO
PA APJCP HEAD OFFICE, KOREAN NATL CANCER CENTER, 323 ILAN -RO,
   ILSANDONG-GU, GOYANG-SI, GYEONGGI-DO, 410-769, SOUTH KOREA
SN 1513-7368
J9 ASIAN PAC J CANCER P
JI Asian Pac. J. Cancer Prev.
PY 2014
VL 15
IS 14
BP 5895
EP 5900
DI 10.7314/APJCP.2014.15.14.5895
PG 6
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA AR6XD
UT WOS:000343723300067
PM 25081719
OA Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Davis, CL
   Kapuku, G
   Snieder, H
   Kumar, M
   Treiber, FA
AF Davis, CL
   Kapuku, G
   Snieder, H
   Kumar, M
   Treiber, FA
TI Insulin resistance syndrome and left ventricular mass in healthy young
   people
SO AMERICAN JOURNAL OF THE MEDICAL SCIENCES
LA English
DT Article; Proceedings Paper
CT Annual Meeting of the American-Psychosomatic-Society
CY MAR 06-10, 2001
CL MONTEREY, CA
SP Amer Psychosomat Soc
DE insulin resistance; risk factors; adolescence; young adulthood; left
   ventricular hypertrophy
ID BODY-FAT DISTRIBUTION; CARDIOVASCULAR RISK; FAMILY HISTORIES; ACUTE
   STRESS; CHILDREN; HYPERTENSION; ASSOCIATION; GEOMETRY; OBESITY; ADULTS
AB Background. Findings of atherosclerotic plaques in adolescents, in the context of current epidemics of obesity and type 2 diabetes in youth, demand investigation into early cardiovascular risk development. Left ventricular hypertrophy has been linked to hypertension, obesity, and insulin resistance. Methods: Insulin resistance syndrome characteristics (fasting glucose and insulin; systolic blood pressure; waist girth) were measured in 70 normotensive, normoglycemic young people (60% male, 62% black; included 13 twin pairs; age mean +/- SD, 19 +/- 2.6 years). Left ventricular mass indexed by height(2.7) (LVMI) was obtained via ultrasound. Twin pairs were clustered to satisfy the assumption for independent observations. Results: LVMI was regressed on insulin after controlling for race, gender, and systolic blood pressure. Insulin was a significant (P = 0.02) independent predictor of LVMI (R-2 change = 0.09, P < 0.01). Waist girth accounted for an additional 4% variance of LVMI (P = 0.05). A one-factor model comprising waist (factor loading = 0.83), insulin (0.59), glucose (0.42), and LVMI (0.46) showed good fit [chi(2)(2) = 0.41, P = 0.81; root-mean-square error of approximation = 0.01. Conclusions: A subclinical metabolic syndrome is detectable early in life, before abnormal fasting glucose or high blood pressure appear. Evidence of excessive load on the heart is associated with the metabolic syndrome even after accounting for the effects of race, gender, and blood pressure. Cardiac structure seems as closely associated with this syndrome as fasting glucose level. Based on this evidence, we propose that increased left ventricular mass is a part of insulin resistance syndrome and adds to the need for preventive public health measures to improve health behaviors and cardiovascular risk status in US youth.
C1 Med Coll Georgia, Georgia Prevent Inst, Augusta, GA 30912 USA.
   Univ Miami, Sch Med, Miami, FL USA.
   St Thomas Hosp, Twin Res & Genet Epidemiol Unit, London, England.
C3 University System of Georgia; Augusta University; University of Miami;
   Guy's & St Thomas' NHS Foundation Trust
RP Med Coll Georgia, Georgia Prevent Inst, 1499 Walton Way HS1640, Augusta, GA 30912 USA.
EM cadavis@mail.mcg.edu
RI Davis, Catherine/A-7522-2011
OI Davis, Catherine Lucy/0000-0002-2942-8233; Kapuku,
   Gaston/0000-0002-0854-1413
FU NHLBI NIH HHS [HL41781, HL35073, HL56622] Funding Source: Medline
CR Barnes VA, 2001, J PSYCHOSOM RES, V51, P597, DOI 10.1016/S0022-3999(01)00261-6
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NR 39
TC 47
Z9 47
U1 0
U2 2
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0002-9629
EI 1538-2990
J9 AM J MED SCI
JI Am. J. Med. Sci.
PD AUG
PY 2002
VL 324
IS 2
BP 72
EP 75
DI 10.1097/00000441-200208000-00005
PG 4
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC General & Internal Medicine
GA 582AM
UT WOS:000177327600004
PM 12186110
DA 2025-06-11
ER

PT J
AU Butnoriene, J
   Steibliene, V
   Saudargiene, A
   Bunevicius, A
AF Butnoriene, Jurate
   Steibliene, Vesta
   Saudargiene, Ausra
   Bunevicius, Adomas
TI Does presence of metabolic syndrome impact anxiety and depressive
   disorder screening results in middle aged and elderly individuals? A
   population based study
SO BMC PSYCHIATRY
LA English
DT Article
DE Depressive disorder; General anxiety disorder; Hospital anxiety and
   depression scale; Metabolic syndrome; Mini international
   neuropsychiatric interview; Screening
ID GENERALIZED ANXIETY; PRIMARY-CARE; HOSPITAL ANXIETY; DSM-IV; PSYCHIATRIC
   MORBIDITY; MOOD DISORDERS; FOLLOW-UP; PREVALENCE; COMORBIDITY; SCALE
AB Background: Depressive and anxiety disorders are common in primary care setting but often remain undiagnosed. Metabolic syndrome (MetS) is also prevalent in the general population and can impair recognition of common mental disorders due to significant co-morbidity and overlap with psychiatric symptoms included in self-reported depression/anxiety screening tools. We investigated if MetS has an impact on the accuracy of current major depressive disorder (MDD) and generalized anxiety disorder (GAD) screening results using the Hospital Anxiety and Depression scale (HADS).
   Methods: A total of 1115 (562 men; mean age 62.0 +/- 9.6 years) individuals of 45+ years of age were randomly selected from the general population and evaluated for current MetS; depressive and anxiety symptoms (HADS); and current MDD and GAD (Mini International Neuropsychiatric Interview [MINI]).
   Results: The MetS was diagnosed in 34.4% of the study participants. Current MDD and GAD were more common in individuals with MetS relative to individuals without MetS (25.3% vs 14.2%, respectively, p < 0.001; and 30.2% vs 20.9%, respectively, p < 0.001). The ROC analyses demonstrated that optimal thresholds of the HADS-Depression subscale for current MDE were >= 9 in individuals with MetS (sensitivity >= 87%, specificity = 73% and PPV = 52%) and >= 8 in individuals without MetS (sensitivity = 81%, specificity = 78% and PPV = 38%). At threshold of = 9 the HADS-Anxiety subscale demonstrated optimal psychometric properties for current GAD screening in individuals with MetS (sensitivity = 91%, specificity = 85% and PPV = 72%) and without MetS (sensitivity = 84%, specificity = 83% and PPV = 56%).
   Conclusions: The HADS is a reliable screening tool for current MDE and GAD in middle aged and elderly population with and without MetS. Optimal thresholds of the HADS-Depression subscale for current MDD is >= 9 for individuals with MetS and >= 8 - without MetS. Optimal threshold of the HADS-Anxiety subscale is >= 9 for current GAD in individuals with and without MetS. The presence of MetS should be considered when interpreting depression screening results.
C1 [Butnoriene, Jurate] Lithuanian Univ Hlth Sci, Inst Endocrinol, Eiveniu Str 2, LT-50161 Kaunas, Lithuania.
   [Steibliene, Vesta] Lithuanian Univ Hlth Sci, Psychiat Clin, Kaunas, Lithuania.
   [Saudargiene, Ausra] Lithuanian Univ Hlth Sci, Kaunas, Lithuania.
   [Saudargiene, Ausra; Bunevicius, Adomas] Lithuanian Univ Hlth Sci, Neurosci Inst, Kaunas, Lithuania.
C3 Lithuanian University of Health Sciences; Lithuanian University of
   Health Sciences; Lithuanian University of Health Sciences; Lithuanian
   University of Health Sciences
RP Butnoriene, J (corresponding author), Lithuanian Univ Hlth Sci, Inst Endocrinol, Eiveniu Str 2, LT-50161 Kaunas, Lithuania.
EM jurate.butnoriene@fc.lsmuni.lt
RI Bunevicius, Adomas/I-3394-2019; Steibliene, Vesta/I-6517-2019
OI Bunevicius, Adomas/0000-0003-0446-6898; Steibliene,
   Vesta/0000-0002-8374-2768
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NR 71
TC 12
Z9 13
U1 0
U2 9
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-244X
J9 BMC PSYCHIATRY
JI BMC Psychiatry
PD JAN 8
PY 2018
VL 18
AR 5
DI 10.1186/s12888-017-1576-8
PG 10
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA FS2SL
UT WOS:000419628700003
PM 29310620
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Marijnissen, RM
   Smits, JEMP
   Schoevers, RA
   van den Brink, RHS
   Holewijn, S
   Franke, B
   de Graaf, J
   Voshaar, RCO
AF Marijnissen, Radboud M.
   Smits, Johanna E. M. P.
   Schoevers, Robert A.
   van den Brink, Rob H. S.
   Holewijn, Suzanne
   Franke, Barbara
   de Graaf, Jacqueline
   Voshaar, Richard C. Oude
TI Association between metabolic syndrome and depressive symptom
   profiles-Sex-specific?
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Depression; Metabolic syndrome X; Aged; Adiponectin
ID ADIPONECTIN; INFLAMMATION; WOMEN; POPULATION; DIMENSIONS; OBESITY; HEART
AB Background: The association between depression and metabolic syndrome is becoming more obvious. Waist circumference (WC) might be the most important metabolic syndrome (MetS) feature in relation to late-life depression, with a possible mediating role for adiponectin.
   Methods: Cross-sectional population based survey of 1277 participants (50-70 years). We measured all components of MetS, plasma adiponectin levels and depressive symptoms using Beck Depression Inventory (BDI). Principal components analysis on the BDI items revealed two factors, representing a cognitive-affective and a somatic-affective symptom-cluster. Multiple linear regression models with the BDI sum score and both depression symptom-clusters as dependent variables, respectively, were used to examine the association with each component of metabolic syndrome adjusted for confounders. We explored sex-differences as well as a hypothesised mediating effect of adiponectin.
   Results: The presence of MetS as well as number of metabolic risk factors were significantly associated with BDI sum score. In men WC, triglycerides and HDL cholesterol explained variance in depressive symptoms, whereas in women this effect was confined to WC. Moreover, irrespective of sex, all associations were primarily driven by the somatic-affective symptom cluster, Adiponectin neither mediated nor moderated any of the associations found.
   Limitations: Cross-sectional design limits causal interpretation. Being a population based survey, some selection bias might have occurred toward healthier part of population.
   Conclusions: Although pathophysiological mechanisms underlying the association between metabolic disturbances and depression remains to be elucidated, our study points to sex differences as well as a specific phenotype of depression that is associated with metabolic disturbances. (C) 2013 Elsevier B.V. All rights reserved
C1 [Marijnissen, Radboud M.; Smits, Johanna E. M. P.] Pro Persona, Dept Old Age Psychiat, Wolfheze Arnhem, Netherlands.
   [Marijnissen, Radboud M.; Schoevers, Robert A.; van den Brink, Rob H. S.; Voshaar, Richard C. Oude] Univ Groningen, Univ Med Ctr Groningen, Dept Psychiat, Groningen, Netherlands.
   [Holewijn, Suzanne; de Graaf, Jacqueline] Radboud Univ Nijmegen, Med Ctr, Div Vasc Med, Dept Gen Internal Med, NL-6525 ED Nijmegen, Netherlands.
   [Franke, Barbara] Radboud Univ Nijmegen, Med Ctr, Dept Human Genet, NL-6525 ED Nijmegen, Netherlands.
   [Franke, Barbara] Radboud Univ Nijmegen, Med Ctr, Dept Psychiat, NL-6525 ED Nijmegen, Netherlands.
C3 University of Groningen; Radboud University Nijmegen; Radboud University
   Nijmegen; Radboud University Nijmegen
RP Marijnissen, RM (corresponding author), Pro Persona, Dept Old Age Psychiat, Wolfheze 2, NL-6874 BE Wolfheze, Gelderland, Netherlands.
EM r.marijnissen@propersona.nl
RI de Graaf, J./H-8038-2014; Franke, Barbara/D-4836-2009
OI Oude Voshaar, Richard/0000-0003-1501-4774; Holewijn,
   Suzanne/0000-0001-7641-1322; Franke, Barbara/0000-0003-4375-6572;
   Schoevers, Robert A/0000-0003-0760-9866
FU Dutch Scientific Organisation (ZonMw) [90700231]
FX R.C. Oude Voshaar is research fellow of the Dutch Scientific
   Organisation (ZonMw) (Research Grant 90700231).
CR Akbaraly TN, 2011, DIABETES CARE, V34, P904, DOI 10.2337/dc10-1644
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NR 37
TC 30
Z9 31
U1 0
U2 10
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD DEC
PY 2013
VL 151
IS 3
BP 1138
EP 1142
DI 10.1016/j.jad.2013.07.029
PG 5
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA 241OC
UT WOS:000326175500047
PM 24011730
DA 2025-06-11
ER

PT J
AU Malas, O
   Muja, A
   Balada, F
   Urieta, P
   Worner, F
AF Malas, Olga
   Muja, Anton
   Balada, Ferran
   Urieta, Patricia
   Worner, Fernando
TI Psychological risk factors for metabolic syndrome: re-exploring the link
SO ANUARIO DE PSICOLOGIA
LA English
DT Article
DE metabolic syndrome (MetS); alexithymia; type A behavior; type D
   personality; anxiety; depression; somatization
ID CORONARY-HEART-DISEASE; TORONTO-ALEXITHYMIA-SCALE; ANGER EXPRESSION;
   PROVISIONAL REPORT; DIABETES-MELLITUS; BLOOD-PRESSURE; D PERSONALITY;
   TRAIT ANGER; DEPRESSION; ASSOCIATION
AB This study re-explores the relationship between metabolic syndrome (MetS), according to IDF and NCEP criteria, and personality and psychopathological variables. We studied trait anger, type A behavior, type D personality, alexithymia, Zuckerman's personality dimensions, anxiety, somatization, depression, and hostility. The sample was 410 males (M-age = 52.54, SD = 10.43). A cross-sectional design was used age with self-report data from questionnaires and biological measures. Participants completed the type D scale (DS14), the Jenkins Activity Survey (JAS), the Toronto Alexithymia Scale (TAS-20), the State-Trait Anger Expression Inventory-2 (STAXI-2), the Brief Symptom Inventory (BSI) and the shortened cross-cultural Zuckerman-Kuhlman Personality Questionnaire (ZKPQ-50-CC). The results show that subjects with IDF/NCEP criteria have significantly high scores in anxiety/negative affect, aggression-hostility, trait anger, alexithymia, negative affect, somatization, depression, and anxiety, but not in type A. No differences were found between both MetS criteria. High scores in somatization, difficulty in describing feelings, impulsive sensation seeking, and low scores in activity predict a small, but significant, part of the variance of systolic pressure, HDC cholesterol, triglycerides, glucose, and waist circumference. This study provides certain evidence for an association between MetS and psychological variables, including psychopathological symptoms, according to IDF and NCEP criteria.
C1 [Malas, Olga; Muja, Anton; Urieta, Patricia] Univ Lleida, Catalonia, Spain.
   [Malas, Olga; Muja, Anton; Balada, Ferran; Urieta, Patricia; Worner, Fernando] Dr Pifarre Fdn IRBLIeida, Lleida Inst Biomed Res, Catalonia, Spain.
   [Muja, Anton] Avda Estudi Gen 4, Lleida 25001, Spain.
   [Balada, Ferran] Autonomous Univ Barcelona, Dept Psychobiol & Methodol Hlth Sci, Catalonia, Spain.
   [Worner, Fernando] Hosp Arnau de Vilanova Lleida, Cardiol Serv, Catalonia, Spain.
C3 Universitat de Lleida; Autonomous University of Barcelona
RP Muja, A (corresponding author), Univ Lleida, Catalonia, Spain.; Muja, A (corresponding author), Dr Pifarre Fdn IRBLIeida, Lleida Inst Biomed Res, Catalonia, Spain.; Muja, A (corresponding author), Avda Estudi Gen 4, Lleida 25001, Spain.
EM anton.aluja@udl.cat
RI Urieta, Patricia/AAZ-3177-2020; Balada, Ferran/C-5570-2008; Aluja,
   Anton/A-7588-2008; Malas, Olga/AAE-6943-2021
OI TOLSA, MARIA DOLORES/0000-0001-5803-2716; Aluja,
   Anton/0000-0002-7865-0287; Balada, Ferran/0000-0001-7406-0135; Malas,
   Olga/0000-0002-9861-198X
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NR 68
TC 0
Z9 0
U1 0
U2 5
PU UNIV BARCELONA, FAC PSICOLOGIA
PI BARCELONA
PA PASSEIG DE LA VALL DE HEBRON 171, BARCELONA, 08035, SPAIN
SN 0066-5126
EI 1988-5253
J9 ANU PSICOL
JI Anu. Psicol.
PY 2020
VL 50
IS 2
BP 66
EP 78
DI 10.1344/ANPSIC2020.50.6
PG 13
WC Psychology; Psychology, Multidisciplinary
WE Emerging Sources Citation Index (ESCI)
SC Psychology
GA ML6FJ
UT WOS:000549559200003
DA 2025-06-11
ER

PT J
AU Nussbaumerova, B
   Rosolova, H
   Krizek, M
   Sefrna, F
   Racek, J
   Müller, L
   Sindberg, C
AF Nussbaumerova, Barbora
   Rosolova, Hana
   Krizek, Miroslav
   Sefrna, Frantisek
   Racek, Jaroslav
   Muller, Ludek
   Sindberg, Christian
TI Chromium Supplementation Reduces Resting Heart Rate in Patients with
   Metabolic Syndrome and Impaired Glucose Tolerance
SO BIOLOGICAL TRACE ELEMENT RESEARCH
LA English
DT Article
DE Metabolic syndrome; Impaired glucose tolerance; Chromium yeast
ID DIABETES-MELLITUS; CARDIOVASCULAR-DISEASES; OXIDATIVE STRESS; INSULIN;
   PICOLINATE; PLASMA; TRIAL
AB Chromium (Cr) is considered as an important mineral, involved in biochemical reactions in human metabolic pathways. Organically bound Cr supplementation has been suggested to improve glycemia especially in patients with type 2 diabetes mellitus, but there are conflicting reports on efficacy. Effect of Cr is not clear in prediabetes status. Seventy patients with metabolic syndrome and impaired glucose tolerance (IGT), who are observed and treated in the Center of Preventive Cardiology of the University Hospital in Pilsen, were included in the prospective, randomized, double-blind, and placebo-controlled clinical study. Effect of Cr-enriched yeast (200 mu g of elementary Cr in the morning and 100 mu g in the evening) on glucose, lipid metabolism, fat tissue hormones, oxidative stress, and DNA damage markers was analyzed. There were no significant changes in glucose and lipid parameters, oxidative stress, or other laboratory markers. Only resting heart rate was significantly reduced in patients treated by Cr yeast, reflecting reduced sympathetic activity. This could represent an important cardiovascular risk reduction in patients with high cardiometabolic risk.
C1 [Nussbaumerova, Barbora; Rosolova, Hana; Krizek, Miroslav; Sefrna, Frantisek] Charles Univ Prague, Med Fac Pilsen, Med Dept 2, Ctr Prevent Cardiol, Plzen, Czech Republic.
   [Nussbaumerova, Barbora; Rosolova, Hana; Krizek, Miroslav; Sefrna, Frantisek; Racek, Jaroslav] Charles Univ Prague, Fac Hosp, Plzen, Czech Republic.
   [Racek, Jaroslav] Charles Univ Prague, Med Fac Pilsen, Inst Clin Biochem & Hematol, Plzen, Czech Republic.
   [Muller, Ludek] Univ West Bohemia, Fac Sci Appl, European Ctr Excellence, New Technol Informat Soc, Plzen, Czech Republic.
   [Sindberg, Christian] Pharma Nord ApS, Res Dept, Vejle, Denmark.
C3 Charles University Prague; Charles University Prague; Charles University
   Prague; University of West Bohemia Pilsen
RP Sindberg, C (corresponding author), Pharma Nord ApS, Res Dept, Vejle, Denmark.
EM cdsindberg@pharmanord.com
RI Muller, Ludek/I-1617-2016
OI Muller, Ludek/0000-0002-6581-6348
FU Charles University Research Grant
FX Christian Sindberg, M.Sc., is an empolyee of Research Department, Pharma
   Nord ApS, Vejle, Denmark. Pharma Nord, Denmark, provided placebo, Cr
   tablets, and glucose solutions for oGTT. However, no monies were
   received from Pharma Nord. Laboratory methods were supported by the
   Charles University Research Grant (Medical Faculty in Pilsen P-36).
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NR 30
TC 24
Z9 24
U1 2
U2 18
PU HUMANA PRESS INC
PI TOTOWA
PA 999 RIVERVIEW DRIVE SUITE 208, TOTOWA, NJ 07512 USA
SN 0163-4984
EI 1559-0720
J9 BIOL TRACE ELEM RES
JI Biol. Trace Elem. Res.
PD JUN
PY 2018
VL 183
IS 2
BP 192
EP 199
DI 10.1007/s12011-017-1128-6
PG 8
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA GF1JC
UT WOS:000431689100002
PM 28856601
DA 2025-06-11
ER

PT J
AU Gobal, F
   Deshmukh, A
   Shah, S
   Mehta, JL
AF Gobal, Freij
   Deshmukh, Abhishek
   Shah, Sudhir
   Mehta, Jawahar L.
TI Triad of Metabolic Syndrome, Chronic Kidney Disease, and Coronary Heart
   Disease With a Focus on Microalbuminuria
SO JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
LA English
DT Review
DE chronic kidney disease; coronary heart disease; metabolic syndrome;
   microalbuminuria
ID LOW-DENSITY-LIPOPROTEIN; FOCAL SEGMENTAL GLOMERULOSCLEROSIS;
   INSULIN-RESISTANCE SYNDROME; URINARY ALBUMIN EXCRETION; ARTERY
   ENDOTHELIAL-CELLS; RENIN-ANGIOTENSIN SYSTEM; CARDIOVASCULAR EVENTS;
   RENAL-DISEASE; LECTIN-LIKE; BLOOD-PRESSURE
AB Coronary heart disease remains a major cause of morbidity and mortality in the United States, and its incidence is rising worldwide. Because atherosclerosis is a chronic process, and it is often associated with certain lifestyle and risk factors such as hypertension, dyslipidemia, and insulin resistance, much emphasis is being placed on lifestyle modification and control of risk factors. It is being recognized that some lifestyle patterns such as overeating result in metabolic syndrome, which may play a role in the development of chronic kidney disease and coronary heart disease. Here, we focus on an important relationship between these 3 conditions, and we provide evidence that microalbuminuria develops in many patients with metabolic syndrome, may be an important correlate of chronic kidney disease and coronary heart disease, and may represent an important prognostic marker. Although the pathogenesis of microalbuminuria in metabolic syndrome is not clear, we suggest that microalbuminuria, chronic kidney disease, and coronary heart disease share common pathways involving inflammation and oxidative stress. We also discuss that a healthy lifestyle is essential for preventing and treating chronic kidney disease and coronary heart disease seen in patients with metabolic syndrome. (J Am Coll Cardiol 2011;57:2303-8) (C) 2011 by the American College of Cardiology Foundation
C1 [Gobal, Freij; Deshmukh, Abhishek; Mehta, Jawahar L.] Univ Arkansas Med Sci, Div Cardiovasc, Little Rock, AR 72212 USA.
   [Gobal, Freij; Deshmukh, Abhishek; Shah, Sudhir; Mehta, Jawahar L.] Vet Affairs Med Ctr, Little Rock, AR USA.
   [Shah, Sudhir] Univ Arkansas Med Sci, Div Nephrol, Little Rock, AR 72212 USA.
C3 University of Arkansas System; University of Arkansas Medical Sciences;
   US Department of Veterans Affairs; Veterans Health Administration (VHA);
   University of Arkansas System; University of Arkansas Medical Sciences
RP Mehta, JL (corresponding author), Univ Arkansas Med Sci, Div Cardiovasc, 4301 W Markham St,Mail Slot 532, Little Rock, AR 72212 USA.
EM MehtaJL@UAMS.edu
RI Mehta, jl/AAB-8832-2019
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NR 81
TC 36
Z9 39
U1 0
U2 4
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0735-1097
EI 1558-3597
J9 J AM COLL CARDIOL
JI J. Am. Coll. Cardiol.
PD JUN 7
PY 2011
VL 57
IS 23
BP 2303
EP 2308
DI 10.1016/j.jacc.2011.02.027
PG 6
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 771HG
UT WOS:000291147200002
PM 21636030
OA Bronze
DA 2025-06-11
ER

PT J
AU Suárez-Ortegón, MF
   Arbeláez, A
   Moreno-Navarrete, JM
   Ortega-Avila, JG
   Mosquera, M
   Fernández-Real, JM
AF Suarez-Ortegon, Milton Fabian
   Arbelaez, Alejandra
   Moreno-Navarrete, Jose Maria
   Ortega-Avila, Jose Guillermo
   Mosquera, Mildrey
   Fernandez-Real, Jose Manuel
TI Soluble Transferrin Receptor, Antioxidant Status and Cardiometabolic
   Risk in Apparently Healthy Individuals
SO ANTIOXIDANTS
LA English
DT Article
DE transferrin receptor; cardiometabolic risk; antioxidant status; iron
ID BODY IRON STORES; OXIDATIVE STRESS; INSULIN-RESISTANCE; METABOLIC
   SYNDROME; SERUM FERRITIN; GLUCOSE; PLASMA; HEPCIDIN; ASSOCIATION;
   CAPACITY
AB Body iron excess appears to be related to insulin resistance and cardiometabolic risk and increased oxidative stress might be involved in this relationship. Very few studies have described the association between soluble transferrin receptor (sTfR) levels and cardiometabolic risk in the general population or antioxidant status. There were 239 subjects (20-65 years old) included in this cross-sectional study. Linear regressions adjusting for BMI, menopausal status, insulin resistance (HOMA-IR), physical inactivity, alcohol intake and subclinical/chronic inflammation were used to describe the association between sTfR, total antioxidant capacity (TAC), and measures of cardio-metabolic risk. sTfR levels were positively associated with TAC in men (beta eta [95% confidence interval ]: 0.31 [0.14 to 0.48]) and women (beta eta = 0.24 [0.07 to 0.40]) in non-adjusted and adjusted models (p < 0.05). In men, sTfR levels were inversely associated with waist circumference (beta eta [95% confidence interval]: -1.12 [-2.30 to -0.22]) and fasting glucose (-2.7 (-4.82 to -0.57), and positively with LDL cholesterol (12.41 (6.08 to 18.57) before and after adjustments for confounding variables. LDL cholesterol had a significant and positive association with TAC in non-adjusted and adjusted models in men (p < 0.05). sTfR levels are significantly associated with antioxidant status and a few specific cardio-metabolic risk variables, independently of covariates that included serum ferritin and hepcidin. This might imply that iron biomarkers in regard to cardiometabolic risk reflect physiological contexts other than iron metabolism.
C1 [Suarez-Ortegon, Milton Fabian] Pontificia Univ Javeriana Secc Cali, Fac Ciencias Salud, Dept Alimentac & Nutr, Cali 760030, Colombia.
   [Suarez-Ortegon, Milton Fabian; Arbelaez, Alejandra; Ortega-Avila, Jose Guillermo; Mosquera, Mildrey] Univ Valle, Nutr Grp, Cali 760030, Colombia.
   [Arbelaez, Alejandra; Mosquera, Mildrey] Univ Valle, Physiol Sci Dept, Cali 760030, Colombia.
   [Moreno-Navarrete, Jose Maria; Fernandez-Real, Jose Manuel] Inst Invest Biomed Girona IdIBGi, Dept Diabet Endocrinol & Nutr, Madrid 28029, Spain.
   [Ortega-Avila, Jose Guillermo] Pontificia Univ Javeriana Secc Cali, Fac Ciencias Salud, Dept Ciencias Bas, Cali 760030, Colombia.
   [Fernandez-Real, Jose Manuel] Inst Salud Carlos III ISCIII, CIBEROBN CB06 03 010, Madrid 28029, Spain.
C3 Pontificia Universidad Javeriana; Universidad del Valle; Universidad del
   Valle; Universitat de Girona; Girona University Hospital Dr. Josep
   Trueta; Institut d'Investigacio Biomedica de Girona (IDIBGI); Pontificia
   Universidad Javeriana; CIBER - Centro de Investigacion Biomedica en Red;
   CIBEROBN
RP Suárez-Ortegón, MF (corresponding author), Pontificia Univ Javeriana Secc Cali, Fac Ciencias Salud, Dept Alimentac & Nutr, Cali 760030, Colombia.; Suárez-Ortegón, MF (corresponding author), Univ Valle, Nutr Grp, Cali 760030, Colombia.; Fernández-Real, JM (corresponding author), Inst Invest Biomed Girona IdIBGi, Dept Diabet Endocrinol & Nutr, Madrid 28029, Spain.; Fernández-Real, JM (corresponding author), Inst Salud Carlos III ISCIII, CIBEROBN CB06 03 010, Madrid 28029, Spain.
EM milton.suarez@javerianacali.edu.co
RI Ortega, Jose Guillermo/AFR-0400-2022; Fernández-Real, Jose
   Manuel/AGH-3599-2022; Moreno-Navarrete, Jose Maria/H-9772-2015;
   Mosquera, Mildrey/AGK-3087-2022
OI ORTEGA AVILA, JOSE GUILLERMO/0000-0003-2112-3870; Suarez Ortegon, Milton
   Fabian/0000-0002-0513-5196; Moreno-Navarrete, Jose
   Maria/0000-0002-2883-511X; Mosquera, Mildrey/0000-0003-0783-5839;
   Fernandez-Real, Jose Manuel/0000-0002-7442-9323
FU Colombian Administrative Department for Development and Science
   Technology (COLCIENCIAS) [1106-45921521]; CIBERobn through FEDER Funds;
   Institut d'Investigacio Biomedica de Girona (IdIBGi)
FX This work was funded by a grant from the Colombian Administrative
   Department for Development and Science Technology (COLCIENCIAS) (grant
   1106-45921521), the Institut d'Investigacio Biomedica de Girona
   (IdIBGi), and the CIBERobn through FEDER Funds.
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NR 36
TC 2
Z9 2
U1 0
U2 3
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD JAN
PY 2023
VL 12
IS 1
AR 19
DI 10.3390/antiox12010019
PG 10
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA 8B4CF
UT WOS:000916871700001
PM 36670881
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Stanková, B
   Macásek, J
   Zeman, M
   Vecka, M
   Tvrzická, E
   Jáchymová, M
   Slaby, A
   Zák, A
AF Stankova, B.
   Macasek, J.
   Zeman, M.
   Vecka, M.
   Tvrzicka, E.
   Jachymova, M.
   Slaby, A.
   Zak, A.
TI Polymorphisms rs2167444 and rs508384 in the SCD1 Gene Are Linked
   with High ApoB-48 Levels and Adverse Profile of Cardiometabolic Risk
   Factors
SO FOLIA BIOLOGICA
LA English
DT Article
DE apolipoprotein B-48; cardiometabolic risk factors; metabolic syndrome
   components; small-dense LDL; oxidative stress; fatty acid desaturases;
   SCD1 polymorphisms
ID STEAROYL-COA DESATURASE; FATTY-ACID-COMPOSITION; APOLIPOPROTEIN B-48
   CONCENTRATION; PERIPHERAL ARTERIAL-DISEASE; REMNANT LIPOPROTEINS;
   METABOLIC SYNDROME; OXIDATIVE MODIFICATION; INSULIN-RESISTANCE; B48
   LEVEL; OBESITY
AB Elevated plasma concentration of apolipoprotein B-48 (apoB-48) is an independent risk factor of cardiovascular disease. Stearoyl-CoA desaturase-1 (SCD1) is a rate-limiting lipogenic enzyme and a key regulator of fuel metabolism. The aim of this study was to analyse associations between clinical, biochemical, and genetic factors and different apoB-48 levels in subjects at increased cardiometabolic risk. We examined 220 subjects exhibiting at least one metabolic syndrome (MetS) component. In conjunction with basic clinical, anthropometric and laboratory measurements, we analysed various polymorphisms of stearoyl-CoA desaturase-1 (SCD1). Subjects were divided into two groups according to the median apoB-48 level: (1) high apoB-48 (>= 7.9 mg/l, N = 112) and (2) low apoB-48 (< 7.9 mg/l, N = 108). Neither group differed significantly in anthropometric measures. High plasma apoB-48 levels were associated with increased systolic blood pressure (+3 %; P < 0.05), MetS prevalence (59.8 vs. 32.4 %; P < 0.001), small-dense LDL frequency (46.4 vs. 20.4 %; P < 0.001), triglycerides (+97 %; P < 0.001), non-HDL-cholesterol (+27 %; P < 0.001), and lower concentrations of HDL-cholesterol (-11 %; P < 0.01). This group was further characterized by a higher HOMA-IR index (+54 %; P < 0.001) and increased concentrations of conjugated dienes (+11 %; P < 0.001) and oxidatively modified LDL (+ 38 %; P < 0.05). Lower frequencies of SCD1 minor genotypes (rs2167444, rs508384, P < 0.05) were observed in subjects with elevated plasma concentrations of apoB-48. Elevated plasma concentrations of apoB-48 are associated with an adverse lipid profile, higher systolic blood pressure, insulin resistance, and oxidative stress. Lower proportions of minor SCD1 genotypes (rs2167444, rs508384) implicate the role of genetic factors in the pathogenesis of elevated levels of apoB-48.
C1 [Stankova, B.; Macasek, J.; Zeman, M.; Vecka, M.; Tvrzicka, E.; Slaby, A.; Zak, A.] Charles Univ Prague, Fac Med 1, Dept Med 4, Nemocnice 2, Prague 12808, Czech Republic.
   [Jachymova, M.] Charles Univ Prague, Fac Med 1, Inst Clin Chem & Lab Diagnost, Prague, Czech Republic.
   [Jachymova, M.] Gen Univ Hosp, Nemocnice 2, Prague 12808, Czech Republic.
C3 Charles University Prague; Charles University Prague; General University
   Hospital Prague
RP Zák, A (corresponding author), Charles Univ Prague, Fac Med 1, Dept Med 4, Nemocnice 2, Prague 12808, Czech Republic.; Zák, A (corresponding author), Gen Univ Hosp, Nemocnice 2, Prague 12808, Czech Republic.
EM zak.ales@email.cz
RI Slaby, Adolf/P-5060-2016; Vecka, Marek/AAB-9358-2022; Stankova,
   Barbora/L-7933-2016; Macasek, Jaroslav/G-8337-2016; Vecka,
   Marek/A-3560-2008; Zak, Ales/G-8318-2016; Zeman, Miroslav/J-5281-2016
OI Stankova, Barbora/0000-0002-6184-4878; Macasek,
   Jaroslav/0000-0002-8009-8970; Vecka, Marek/0000-0002-3269-1817; Zak,
   Ales/0000-0002-1698-6068; Zeman, Miroslav/0000-0001-5338-603X
FU Ministry of Education, Youth and Sports of the Czech Republic (Charles
   University, First Faculty of Medicine) [PROGRES Q25/LF1/2]; Ministry of
   Health of the Czech Republic [RVO-VFN64165/2012]
FX Financial support from the Ministry of Health of the Czech Republic
   (research project RVO-VFN64165/2012) and the Ministry of Education,
   Youth and Sports of the Czech Republic (research project PROGRES
   Q25/LF1/2 - Charles University, First Faculty of Medicine) is gratefully
   acknowledged.
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NR 67
TC 4
Z9 4
U1 0
U2 1
PU CHARLES UNIV PRAGUE, FIRST FACULTY MEDICINE
PI PRAGUE 6
PA FLEMINGOVO NAM. 2, PRAGUE 6 166 37, CZECH REPUBLIC
SN 0015-5500
J9 FOLIA BIOL-PRAGUE
JI Folia Biol.-Prague
PY 2019
VL 65
IS 4
BP 159
EP 169
PG 11
WC Biochemistry & Molecular Biology; Biology; Oncology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Oncology; Cell Biology
GA KD1HW
UT WOS:000507623700001
PM 31903889
DA 2025-06-11
ER

PT J
AU Zore, T
   Joshi, NV
   Lizneva, D
   Azziz, R
AF Zore, Temeka
   Joshi, Nikhil V.
   Lizneva, Daria
   Azziz, Ricardo
TI Polycystic Ovarian Syndrome: Long-Term Health Consequences
SO SEMINARS IN REPRODUCTIVE MEDICINE
LA English
DT Article
DE polycystic ovarian syndrome; health consequences; metabolic dysfunction;
   cardiovascular disease; type 2 diabetes mellitus; endometrial
   adenocarcinoma; breast cancer; hypertension; depression; anxiety
ID QUALITY-OF-LIFE; IMPAIRED GLUCOSE-TOLERANCE; BREAST-CANCER RISK;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; DIABETES-MELLITUS; FOLLOW-UP;
   CARDIOVASCULAR-DISEASE; INCREASED PREVALENCE; UTERINE FIBROIDS
AB Polycystic ovarian syndrome (PCOS) is the most common endocrinopathy in women and can be associated with significant adverse sequelae that can affect overall long-term health and well-being. This review provides a succinct but comprehensive overview of our current understanding concerning the known morbidities of PCOS, beginning with a review of the importance of the different phenotypes of PCOS in determining long-term morbidity, the confounding impact of obesity on health outcomes in PCOS, and the immediate short-term consequences of the disorder (including dermatologic, reproductive, and mood disturbances). The longer-term morbidities of PCOS are then reviewed including metabolic consequences (impaired glucose tolerance and type 2 diabetes mellitus, metabolic syndrome, and nonalcoholic fatty liver disease), dyslipidemia and vascular dysfunction (including hypertension and increased incidences of cerebrovascular accidents and thromboembolisms on oral contraceptives), neoplastic (primarily endometrial adenocarcinoma), and mental health disorders (including greater incidences of depressive and anxiety disturbances and psychosexual dysfunction). In conclusion, strategies for the prevention and amelioration of long-term morbidities in PCOS are presented.
C1 [Zore, Temeka; Joshi, Nikhil V.; Azziz, Ricardo] Univ Calif Los Angeles, David Geffen Sch Med, Dept Obstet & Gynecol, Los Angeles, CA 90095 USA.
   [Lizneva, Daria; Azziz, Ricardo] Augusta Univ, Med Coll Georgia, Dept Obstet & Gynecol, Augusta, GA USA.
   [Azziz, Ricardo] State Univ New York Syst Adm, Off Acad Hlth & Hosp Affairs, Albany, NY USA.
C3 University of California System; University of California Los Angeles;
   University of California Los Angeles Medical Center; David Geffen School
   of Medicine at UCLA; University System of Georgia; Augusta University
RP Azziz, R (corresponding author), Univ Calif Los Angeles, David Geffen Sch Med, Dept Obstet & Gynecol, Los Angeles, CA 90095 USA.; Azziz, R (corresponding author), SUNY Albany, State Univ Plaza,S-423,353 Broadway, Albany, NY 12246 USA.
EM ricardo.azziz@suny.edu
RI Lizneva, Daria/R-5572-2016; Azziz, Ricardo/N-7229-2014; Azziz,
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OI Azziz, Ricardo/0000-0002-3917-0483; Lizneva, Daria
   V./0000-0002-2489-2635; Lizneva, Daria/0000-0002-2901-4268
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NR 94
TC 41
Z9 42
U1 1
U2 25
PU THIEME MEDICAL PUBL INC
PI NEW YORK
PA 333 SEVENTH AVE, NEW YORK, NY 10001 USA
SN 1526-8004
EI 1526-4564
J9 SEMIN REPROD MED
JI Semin. Reprod. Med.
PD MAY
PY 2017
VL 35
IS 3
BP 271
EP 281
DI 10.1055/s-0037-1603096
PG 11
WC Obstetrics & Gynecology; Reproductive Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology; Reproductive Biology
GA EZ2HG
UT WOS:000404529800011
PM 28658711
DA 2025-06-11
ER

PT J
AU Bonora, E
AF Bonora, E
TI The metabolic syndrome and cardiovascular disease
SO ANNALS OF MEDICINE
LA English
DT Review
DE cardiovascular disease; central obesity; dyslipidaemia; hypertension;
   insulin resistance; metabolic syndrome; microalbuminuria; type 2
   diabetes mellitus
ID CORONARY-HEART-DISEASE; C-REACTIVE PROTEIN; INSULIN-RESISTANCE SYNDROME;
   DENSITY-LIPOPROTEIN CHOLESTEROL; SAN-ANTONIO HEART;
   PLASMINOGEN-ACTIVATOR INHIBITOR; MIDDLE-AGED MEN; CIRCULATING ADHESION
   MOLECULES; FUTURE MYOCARDIAL-INFARCTION; HOMEOSTASIS MODEL ASSESSMENT
AB The metabolic syndrome, which is very common in the general population, is defined by the clustering of several classic cardiovascular risk factors, such as type 2 diabetes, hypertension, high triglycerides and low high-density lipoprotein cholesterol (HDL). Central obesity and insulin resistance, which are the two underlying disorders of the syndrome, are further risk factors for cardiovascular disease. Moreover, a panel of novel (non-traditional) risk factors are ancillary features of the metabolic syndrome. They include biomarkers of chronic mild inflammation (e.g. C-reactive protein, CRP), increased oxidant stress (e.g. oxidized low density lipoprotein, LDL), thrombophilia (e.g. plasminogen activator inhibitor-1, PAI-1) and endothelial dysfunction (e.g. E-selectin). Therefore, subjects with the metabolic syndrome are potentially at high risk of developing atherosclerosis and clinical cardiovascular events.
   In recent years several longitudinal studies have confirmed that subjects with the metabolic syndrome present with atherosclerosis and suffer from myocardial infarction and stroke at rates higher than subjects without the syndrome. The risk of cardiovascular disease (CVD) is particularly high in women with the syndrome and in subjects with pre-existing diabetes, CVD and/or high CRP. However, an increased risk is already present in subjects with a cluster of multiple mild abnormalities. The risk related to the metabolic syndrome is definitely higher when subjects affected are compared to subjects free of any metabolic abnormality.
C1 Univ Verona, Sch Med, Dept Endocrinol & Metab Dis, I-37100 Verona, Italy.
C3 University of Verona
RP Osped Maggiore, Piazzale Stefani 1, I-37126 Verona, Italy.
EM enzo.bonora@univr.it
RI Bonora, Enzo/AAA-5300-2022
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NR 211
TC 165
Z9 185
U1 4
U2 18
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0785-3890
EI 1365-2060
J9 ANN MED
JI Ann. Med.
PY 2006
VL 38
IS 1
BP 64
EP 80
DI 10.1080/07853890500401234
PG 17
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 013NP
UT WOS:000235416300008
PM 16448990
OA Bronze, Green Submitted
DA 2025-06-11
ER

PT J
AU Wester, VL
   van Rossum, EFC
AF Wester, Vincent L.
   van Rossum, Elisabeth F. C.
TI Clinical applications of cortisol measurements in hair
SO EUROPEAN JOURNAL OF ENDOCRINOLOGY
LA English
DT Review
ID LONG-TERM CORTISOL; POSTTRAUMATIC-STRESS-DISORDER; HYDROCORTISONE
   REPLACEMENT THERAPY; CYCLIC CUSHINGS-SYNDROME; PITUITARY-ADRENAL AXIS;
   BODY-MASS INDEX; SCALP HAIR; BIPOLAR DISORDER; HEALTHY-CHILDREN;
   MENTAL-HEALTH
AB Cortisol measurements in blood, saliva and urine are frequently used to examine the hypothalamus-pituitary-adrenal (HPA) axis in clinical practice and in research. However, cortisol levels are subject to variations due to acute stress, the diurnal rhythm and pulsatile secretion. Cortisol measurements in body fluids are not always a reflection of long-term cortisol exposure. The analysis of cortisol in scalp hair is a relatively novel method to measure cumulative cortisol exposure over months up to years. Over the past years, hair cortisol concentrations (HCC) have been examined in association with a large number of somatic and mental health conditions. HCC can be used to evaluate disturbances of the HPA axis, including Cushing's syndrome, and to evaluate hydrocortisone treatment. Using HCC, retrospective timelines of cortisol exposure can be created which can be of value in diagnosing cyclic hypercortisolism. HCC have also been shown to increase with psychological stressors, including major life events, as well as physical stressors, such as endurance exercise and shift work. Initial studies show that HCC may be increased in depression, but decreased in general anxiety disorder. In posttraumatic stress disorder, changes in HCC seem to be dependent on the type of traumatic experience and the time since traumatization. Increased hair cortisol is consistently linked to obesity, metabolic syndrome and cardiovascular disease. Potentially, HCC could form a future marker for cardiovascular risk stratification, as well as serve as a treatment target.
C1 [Wester, Vincent L.; van Rossum, Elisabeth F. C.] Erasmus MC, Univ Med Ctr Rotterdam, Dept Internal Med, Div Endocrinol, NL-3000 CA Rotterdam, Netherlands.
C3 Erasmus University Rotterdam; Erasmus MC
RP van Rossum, EFC (corresponding author), Erasmus MC, Room D428,POB 2040, NL-3000 CA Rotterdam, Netherlands.
EM e.vanrossum@erasmusmc.nl
RI van Rossum, Elisabeth/AAP-9388-2020
OI van Rossum, Elisabeth/0000-0003-0120-4913
FU Thrasher Research Fund [TRF11643]; Netherlands Brain Foundation
   [F2011(1)-12]; Erasmus MC Fellowship
FX The last author (E F C van Rossum) supported by the Thrasher Research
   Fund (TRF11643), The Netherlands Brain Foundation (grant number
   F2011(1)-12) and an Erasmus MC Fellowship.
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NR 72
TC 154
Z9 168
U1 0
U2 66
PU BIOSCIENTIFICA LTD
PI BRISTOL
PA EURO HOUSE, 22 APEX COURT WOODLANDS, BRADLEY STOKE, BRISTOL BS32 4JT,
   ENGLAND
SN 0804-4643
EI 1479-683X
J9 EUR J ENDOCRINOL
JI Eur. J. Endocrinol.
PD OCT
PY 2015
VL 173
IS 4
BP M1
EP M10
DI 10.1530/EJE-15-0313
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA CQ3HE
UT WOS:000360491900001
PM 25924811
DA 2025-06-11
ER

PT J
AU Ceci, FM
   Ferraguti, G
   Petrella, C
   Greco, A
   Tirassa, P
   Iannitelli, A
   Ralli, M
   Vitali, M
   Ceccanti, M
   Chaldakov, GN
   Versacci, P
   Fiore, M
AF Ceci, Flavio Maria
   Ferraguti, Giampiero
   Petrella, Carla
   Greco, Antonio
   Tirassa, Paola
   Iannitelli, Angela
   Ralli, Massimo
   Vitali, Mario
   Ceccanti, Mauro
   Chaldakov, George N.
   Versacci, Paolo
   Fiore, Marco
TI Nerve Growth Factor, Stress and Diseases
SO CURRENT MEDICINAL CHEMISTRY
LA English
DT Review
DE Stress; Nerve Growth Factor (NGF); mental disorders; metabolic syndrome;
   alcohol use disorders; me-tabolism disorder
ID SCHISTOSOMA-MANSONI INFECTION; PASSIVE-AVOIDANCE RESPONSE; P75
   NEUROTROPHIN RECEPTOR; EARLY-LIFE STRESS; METABOLIC SYNDROME; BRAIN NGF;
   ANIMAL-MODELS; SERUM-LEVELS; CARDIOVASCULAR-DISEASE; OXIDATIVE STRESS
AB Stress is a constant threat for homeostasis and is represented by different extrinsic and intrinsic stimuli (stressors, Hans Selye's "noxious agents"), such as aggressive behavior, fear, diseases, physical activity, drugs, surgical injury, and environmental and physiological changes. Our organisms respond to stress by activating the adaptive stress system to activate compensatory responses for restoring homeostasis. Nerve Growth Factor (NGF) was discovered as a signaling molecule involved in survival, protection, differentiation, and proliferation of sympathetic and peripheral sensory neurons. NGF mediates stress with an important role in translating environmental stimuli into physiological and pathological feedbacks since NGF levels undergo important variations after exposure to stressful events. Psychological stress, lifestyle stress, and oxidative stress are well known to increase the risk of mental disorders such as schizophrenia, major depressive disorders, bipolar disorder, alcohol use disorders and metabolic disorders such as metabolic syndrome. This review reports recent works describing the activity of NGF in mental and metabolic disorders related to stress.
C1 [Ceci, Flavio Maria; Ferraguti, Giampiero] Sapienza Univ Rome, Dept Expt Med, Rome, Italy.
   [Petrella, Carla; Tirassa, Paola; Fiore, Marco] IBBC CNR, Inst Biochem & Cell Biol, Rome, Italy.
   [Greco, Antonio; Ralli, Massimo; Fiore, Marco] Sapienza Univ Rome, Dept Sense Organs, Viale Policlin 155, I-00161 Rome, Italy.
   [Iannitelli, Angela] Univ Aquila, Dept Biotechnol & Appl Clin Sci, Rome, Italy.
   [Vitali, Mario] AV4, ASUR Marche, Ancona, Italy.
   [Ceccanti, Mauro] ASL Roma 1, Ctr Riferimento Alcol Reg Lazio, Rome, Italy.
   [Chaldakov, George N.] Med Univ, Dept Anat & Cell Biol, Varna, Bulgaria.
   [Chaldakov, George N.] Inst Adv Study, Varna, Bulgaria.
   [Versacci, Paolo] Sapienza Univ Hosp Rome, Dept Pediat, Rome, Italy.
C3 Sapienza University Rome; Consiglio Nazionale delle Ricerche (CNR);
   Istituto di Biochimica e Biologia Cellulare (IBBC-CNR); Sapienza
   University Rome; University of L'Aquila; Medical University Varna;
   Sapienza University Rome
RP Fiore, M (corresponding author), IBBC CNR, Inst Biochem & Cell Biol, Rome, Italy.; Fiore, M (corresponding author), Sapienza Univ Rome, Dept Sense Organs, Viale Policlin 155, I-00161 Rome, Italy.
EM marcofiore.roma@gmail.com
RI Ceci, Flavio Maria/AAI-1510-2021; Ceccanti, Mauro/MVW-1162-2025;
   Petrella, Carla/AAX-1265-2020; Tirassa, Paola/JAO-0252-2023; Fiore,
   Marco/GLT-0780-2022; Ralli, Massimo/E-1780-2018
OI fiore, marco/0000-0001-6806-9715; Ceci, Flavio
   Maria/0000-0001-7744-218X; Petrella, Carla/0000-0003-0651-1816; greco,
   antonio/0000-0002-4824-9871; Ralli, Massimo/0000-0001-8776-0421;
   TIRASSA, PAOLA/0000-0002-8791-4424; FERRAGUTI,
   Giampiero/0000-0001-6129-4071
FU Sapienza Universita di Roma, Italy; IBBC-CNR [CNR 0002744-2017]
FX Authors thank Sapienza Universita di Roma, Italy and IBBC-CNR for
   supporting the study (Grant Number CNR 0002744-2017).
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NR 234
TC 41
Z9 41
U1 0
U2 19
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 0929-8673
EI 1875-533X
J9 CURR MED CHEM
JI Curr. Med. Chem.
PY 2021
VL 28
IS 15
BP 2943
EP 2959
DI 10.2174/0929867327999200818111654
PG 17
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Pharmacology &
   Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
GA TI4BQ
UT WOS:000672742400003
PM 32811396
DA 2025-06-11
ER

PT J
AU McClain, CJ
   Mokshagundam, PL
   Barve, SS
   Song, ZY
   Hill, DB
   Chen, T
   Deaciuc, I
AF McClain, CJ
   Mokshagundam, PL
   Barve, SS
   Song, ZY
   Hill, DB
   Chen, T
   Deaciuc, I
TI Mechanisms of non-alcoholic steatohepatitis
SO ALCOHOL
LA English
DT Article; Proceedings Paper
CT Symposium on Role of Fatty Liver Dietary Fatty Acid Supplements and
   Obesity in the Progression of Alcoholic Liver Disease
CY OCT 03, 2003
CL Bethesda, MD
DE non-alcoholic steatohepatitis; fatty liver; cytokines; mitochondria;
   oxidative stress
ID TUMOR-NECROSIS-FACTOR; FATTY LIVER-DISEASE; TYPE-2 DIABETIC-PATIENTS;
   INDUCED HEPATIC-INJURY; INSULIN-RESISTANCE; S-ADENOSYLMETHIONINE;
   FACTOR-ALPHA; METABOLIC SYNDROME; OXIDATIVE STRESS; ALCOHOLIC HEPATITIS
AB In 1980, the term non-alcoholic steatohepatitis was coined to describe a new syndrome occurring in patients who usually were obese (often diabetic) females who had a liver biopsy picture consistent with alcoholic hepatitis, but who denied alcohol use. The causes of this syndrome were unknown, and there was no defined therapy. More than two decades later, this clinical syndrome is only somewhat better understood, and still there is no Food and Drug Administration-approved or even generally accepted drug therapy. Patients with primary non-alcoholic steatohepatitis typically have the insulin resistance syndrome (synonymous with the metabolic syndrome, syndrome X, and so forth), which is characterized by obesity, diabetes, hyperlipidemia, hypertension, and, in some instances, other metabolic abnormalities such as polycystic ovary disease. Secondary non-alcoholic steatohepatitis may be caused by drugs such as tamoxifen, certain industrial toxins, rapid weight loss, and so forth. The cause of non-alcoholic steatohepatitis remains elusive, but most investigators agree that a baseline of steatosis requires a second hit capable of inducing inflammation, fibrosis, or necrosis for non-alcoholic steatohepatitis to develop. Our research group has focused its efforts on the interactions of nutritional abnormalities, cytokines, oxidative stress with lipid peroxidation, and mitochondrial dysfunction in the induction of steatohepatitis, both alcoholic and non-alcoholic in origin. Research findings from other laboratories also support the role of increased cytokine activity, oxidative stress, and mitochondrial dysfunction in the pathogenesis of non-alcohofic steatohepatitis. The objectives of this article are to review the (1) definition and clinical features of non-alcoholic steatohepatitis, (2) potential mechanisms of non-alcoholic steatohepatitis, and (3) potential therapeutic interventions in non-alcoholic steatohepatitis. (C) 2005 Elsevier Inc. All rights reserved.
C1 Univ Louisville, Ctr Med, Dept Internal Med, Louisville, KY 40292 USA.
   Univ Louisville, Hlth Sci Ctr, Dept Pharmacol & Toxicol, Louisville, KY 40202 USA.
C3 University of Louisville; University of Louisville
RP Univ Louisville, Ctr Med, Dept Internal Med, 530 S Jackson St,ACB 3rd Floor, Louisville, KY 40292 USA.
EM craig.mcclain@louisville.edu
RI Barve, Sunita/GRN-8021-2022
FU NIAAA NIH HHS [AA014185, AA000297, AA013170, AA010496, AA010762] Funding
   Source: Medline
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NR 101
TC 86
Z9 103
U1 0
U2 17
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0741-8329
EI 1873-6823
J9 ALCOHOL
JI Alcohol
PD AUG
PY 2004
VL 34
IS 1
BP 67
EP 79
DI 10.1016/j.alcohol.2004.07.007
PG 13
WC Substance Abuse; Pharmacology & Pharmacy; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Substance Abuse; Pharmacology & Pharmacy; Toxicology
GA 898KB
UT WOS:000227074600011
PM 15670668
DA 2025-06-11
ER

PT J
AU Mohammadi, A
   Sahebkar, A
   Kermani, T
   Zhilaee, M
   Tavallaie, S
   Mobarhan, MG
AF Mohammadi, Akram
   Sahebkar, Amirhossein
   Kermani, Tayyebeh
   Zhilaee, Marzieh
   Tavallaie, Shima
   Mobarhan, Majid Ghayour
TI Barberry Administration and Pro-Oxidant-Antioxidant Balance in Patients
   With Metabolic Syndrome
SO IRANIAN RED CRESCENT MEDICAL JOURNAL
LA English
DT Article
DE Metabolic Cardiovascular Syndrome; Berberidaceae; Randomized Controlled
   Trial
ID CORONARY-ARTERY-DISEASE; BERBERIS-VULGARIS L.; OXIDATIVE STRESS
AB Background: Metabolic syndrome is the constellation of several cardiometabolic risk factors, and is associated with a heightened risk of coronary heart disease (CHD). The pro-oxidant-antioxidant balance (PAB) is a measure of factors that promote and control oxidative stress. PAB may also be associated with the risk factors of CHD.
   Objectives: This study aimed to explore the impact of supplementation with barberry, a fruit rich in antioxidants, on PAB in patients with metabolic syndrome.
   Patients and Methods: A total of 106 patients diagnosed with metabolic syndrome were randomized in two groups: case and control. The case group received three capsules of barberry and the control group received three capsules of placebo for 6 weeks. Serum PAB was measured in all patients before and after the intervention.
   Results: There was no significant difference between the groups regarding their baseline PAB values (P = 0.32). A significant decrease in PAB was observed in the barberry group (P = 0.022), whilst there was no significant change in the control group (P = 0.18). The magnitude of change in PAB during the study was significantly greater in the case group compared to the control group (P = 0.01).
   Conclusions: Barberry supplementation reduces oxidative burden in patients with metabolic syndrome.
C1 [Mohammadi, Akram; Sahebkar, Amirhossein; Kermani, Tayyebeh; Zhilaee, Marzieh; Tavallaie, Shima; Mobarhan, Majid Ghayour] Mashhad Univ Med Sci, Biochem Nutr Res Ctr, Mashhad, Iran.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Biotechnol Res Ctr, Mashhad, Iran.
C3 Mashhad University of Medical Sciences; Mashhad University of Medical
   Sciences
RP Mobarhan, MG (corresponding author), Mashhad Univ Med Sci, Biochem Nutr Res Ctr, Mashhad, Iran.
EM ghayourm@mums.ac.ir
RI Sahebkar, Amirhossein/B-5124-2018; kermani, tayyebe/M-1171-2017;
   Ghayour-Mobarhan, Majid/AAY-5963-2020
FU Research Council at Mashhad University of Medical Sciences, Mashhad,
   Iran
FX This work was financially supported by the Research Council at Mashhad
   University of Medical Sciences, Mashhad, Iran.
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NR 30
TC 14
Z9 14
U1 0
U2 4
PU KOWSAR PUBL
PI HOENSBROEK
PA PATERSWEG 22,, HOENSBROEK, LIMBURG 6431 GC, NETHERLANDS
SN 2074-1804
EI 2074-1812
J9 IRAN RED CRESCENT ME
JI Iran. Red Crescent Med. J.
PD DEC
PY 2014
VL 16
IS 12
AR e16786
DI 10.5812/ircmj.16786
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA AX8OE
UT WOS:000347167800007
PM 25763235
OA Green Submitted, Bronze, Green Published
DA 2025-06-11
ER

PT J
AU da Silva, LEM
   Costa, PRD
   Magalhaes, KBBD
   Cunha, CD
   Alves, WPD
   Pereira, EM
   de Santana, MLP
AF da Silva, Lais Eloy Machado
   Costa, Priscila Ribas de Farias
   Magalhaes, Karine Brito Beck da Silva
   Cunha, Carla de Magalhaes
   Alves, Wilanne Pinheiro de Oliveira
   Pereira, Emile Miranda
   de Santana, Monica Leila Portela
TI Dietary Pattern and Depressive Outcomes in Children and Adolescents:
   Systematic Review and Meta-analysis of Observational Studies
SO NUTRITION REVIEWS
LA English
DT Review; Early Access
DE dietary pattern; depression; adolescents; meta-analysis
ID MENTAL-HEALTH PROBLEMS; CARDIOMETABOLIC RISK; OXIDATIVE STRESS;
   ASSOCIATION; SYMPTOMS; QUALITY; ANXIETY; ADHERENCE; LIFE; ADULTS
AB Context Research suggests that dietary pattern plays an important role in mental health and constitutes a modifiable risk factor for depression.Objective The aim of this systematic review and meta-analysis was to evaluate the association between dietary patterns and depressive outcomes in adolescents.Data Sources Medline/PubMed, Lilacs, EMBASE, PsycINFO, and PsycARTICLES, gray literature up to March 2024 were searched; the reference lists were also verified. Observational studies in participants with a mean age <= 19 years reporting associations between dietary patterns and clinical depression or depressive symptoms were searched. Overall, 21 studies were included in this systematic review.Data Extraction Data from eligible articles were extracted by 2 reviewers.Data Analysis Odds ratios (ORs) and confidence intervals (CIs) were determined under a random-effects model. The risk of bias assessment was conducted by 2 independent researchers using the Joanna Briggs Institute Critical Appraisal Checklist tool.Results The qualitative results revealed that a higher unhealthy diet score was positively associated with depressive symptoms, while a healthy diet was negatively associated with depressive symptoms. In the study that included adolescents with a clinical diagnosis of depression, the relationship between inflammatory dietary pattern tertiles and depression was attenuated after all covariates were adjusted for. The meta-analysis to evaluate the association between depressive symptoms and a posteriori dietary patterns found that the "healthy" dietary pattern decreased depressive symptoms in adolescents (OR: 0.69; 95% CI: 0.44, 0.95). There was no statistically significant association between depressive symptoms and "unhealthy" and "snacks" patterns (OR: 1.20 [95% CI: 0.95, 1.46]; OR: 1.20 [95% CI: 0.70, 1.48]) dietary patterns.Conclusion The results identified that a healthy dietary pattern decreased depressive symptoms in adolescents. However, considering the high heterogeneity and the low level of certainty of the evidence, these results should be interpreted with caution.Systematic Review Registration PROSPERO registration no. CRD42020159921.
C1 [da Silva, Lais Eloy Machado; Alves, Wilanne Pinheiro de Oliveira; Pereira, Emile Miranda] Univ Fed Bahia, Food Nutr & Hlth Postgrad Program, Araujo Pinho Ave,32, BR-40110150 Salvador, BA, Brazil.
   [Costa, Priscila Ribas de Farias; Magalhaes, Karine Brito Beck da Silva; Cunha, Carla de Magalhaes; de Santana, Monica Leila Portela] Univ Fed Bahia, Sci Nutr Dept, BR-40110150 Salvador, BA, Brazil.
C3 Universidade Federal da Bahia; Universidade Federal da Bahia
RP da Silva, LEM (corresponding author), Univ Fed Bahia, Food Nutr & Hlth Postgrad Program, Araujo Pinho Ave,32, BR-40110150 Salvador, BA, Brazil.
EM laieloy@hotmail.com
RI DE FARIAS COSTA, PRISCILA/AIB-6441-2022; Cunha, Carla/ABB-5382-2021
OI CUNHA, CARLA/0000-0002-9644-7194
FU Coordenao de Aperfeioamento de Pessoal de Nvel Superior-Brasil; FAPESB
   (Foundation for Research Support in Bahia)
FX The authors thank the FAPESB (Foundation for Research Support in Bahia)
   for providing a scholarship to this study.
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NR 78
TC 0
Z9 0
U1 0
U2 0
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0029-6643
EI 1753-4887
J9 NUTR REV
JI Nutr. Rev.
PD 2025 APR 15
PY 2025
DI 10.1093/nutrit/nuae182
EA APR 2025
PG 18
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 1JX5Z
UT WOS:001466788500001
PM 40233215
DA 2025-06-11
ER

PT J
AU Bilu, C
   Einat, H
   Barak, O
   Zimmet, P
   Vishnevskia-Dai, V
   Govrin, A
   Agam, G
   Kronfeld-Schor, N
AF Bilu, Carmel
   Einat, Haim
   Barak, Orly
   Zimmet, Paul
   Vishnevskia-Dai, Vicktoria
   Govrin, Amanda
   Agam, Galila
   Kronfeld-Schor, Noga
TI Linking type 2 diabetes mellitus, cardiac hypertrophy and depression in
   a diurnal animal model
SO SCIENTIFIC REPORTS
LA English
DT Article
ID ANXIETY-LIKE BEHAVIORS; FAT SAND RAT; METABOLIC SYNDROME; CIRCADIAN
   CLOCK; CARDIOVASCULAR-DISEASE; COMORBID DEPRESSION; INSULIN-RESISTANCE;
   ACTIVITY RHYTHMS; SHORT DAYLIGHT; RODENTS
AB It was recently suggested that the Metabolic Syndrome should be renamed to "Circadian Syndrome". In this context, we explored the effects of living under standard laboratory conditions, where light is the only cycling variable (relevant to human modern life), in a diurnal mammal, on the relationships between affective-like pathology, type 2 diabetes mellitus (T2DM), and cardiac hypertrophy. After 20 weeks, some of the animals spontaneously developed T2DM, depressive and anxiety-like behavior and cardiac hypertrophy. There were significant correlations between levels of anxiety-like behavior and glucose tolerance, and between heart/total body weight ratio and glucose tolerance. Our data suggest a relationship between the development of T2DM, emotional and cardiac pathology as seen in diurnal humans. Furthermore, our data show a possible relationship between reduced daily cycling cues in the laboratory and what has been regularly termed "Metabolic Syndrome" and recently proposed by us to be renamed to "Circadian Syndrome".
C1 [Bilu, Carmel; Barak, Orly; Govrin, Amanda; Kronfeld-Schor, Noga] Tel Aviv Univ, Sch Zool, Ramat Aviv, Israel.
   [Bilu, Carmel; Einat, Haim; Agam, Galila] Ben Gurion Univ Negev, Dept Clin Biochem & Pharmacol, Beer Sheva, Israel.
   [Einat, Haim] Tel Aviv Yaffo Acad Coll, Sch Behav Sci, Tel Aviv, Israel.
   [Zimmet, Paul] Monash Univ, Cent Clin Sch, Dept Diabet, Melbourne, Vic, Australia.
   [Vishnevskia-Dai, Vicktoria] Tel Aviv Univ, Sackler Fac Med, Cha Sheba Med Ctr, Ocular Oncol & Autoimmune Serv,Goldschleger Eye I, Tel Aviv, Israel.
C3 Tel Aviv University; Ben-Gurion University of the Negev; Monash
   University; Tel Aviv University; Sackler Faculty of Medicine
RP Kronfeld-Schor, N (corresponding author), Tel Aviv Univ, Sch Zool, Ramat Aviv, Israel.
EM nogaks@tauex.tau.ac.il
RI Einat, Haim/AAZ-9746-2020; Zimmet, Paul/H-7635-2013; Kronfeld-Schor,
   Noga/AAU-3792-2020
OI Kronfeld-Schor, Noga/0000-0002-5224-3341
FU Israel Science Foundation [866/17]
FX This research was supported by the Israel Science Foundation (grant No.
   866/17).
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NR 83
TC 15
Z9 15
U1 0
U2 8
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD AUG 14
PY 2019
VL 9
AR 11865
DI 10.1038/s41598-019-48326-7
PG 7
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA IQ3UW
UT WOS:000480678100064
PM 31413352
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Rosson, S
   Monaco, F
   Miola, A
   Cascino, G
   Stubbs, B
   Correll, CU
   Firth, J
   Ermis, C
   Perrotti, A
   Marciello, F
   Carvalho, AF
   Brunoni, AR
   Fusar-Poli, P
   Fornaro, M
   Gentile, G
   Granziol, U
   Pigato, G
   Favaro, A
   Solmi, M
AF Rosson, Stella
   Monaco, Francesco
   Miola, Alessandro
   Cascino, Giammarco
   Stubbs, Brendon
   Correll, Christoph U.
   Firth, Joseph
   Ermis, Cagatay
   Perrotti, Andrea
   Marciello, Francesca
   Carvalho, Andre F.
   Brunoni, Andre R.
   Fusar-Poli, Paolo
   Fornaro, Michele
   Gentile, Giovanni
   Granziol, Umberto
   Pigato, Giorgio
   Favaro, Angela
   Solmi, Marco
TI Longitudinal Course of Depressive, Anxiety, and Posttraumatic Stress
   Disorder Symptoms After Heart Surgery: A Meta-Analysis of 94 Studies
SO PSYCHOSOMATIC MEDICINE
LA English
DT Review
DE depression; anxiety; cardiovascular diseases; heart surgery;
   posttraumatic stress disorder; CABG = coronary artery bypass graft; CHD
   = coronary heart disease; CI = confidence interval; CVD = cardiovascular
   disease; HF = heart failure; HS = heart surgery; HT = heart
   transplantation; ICD = implantable cardioverter-defibrillator; MetS =
   metabolic syndrome; NOS = Newcastle-Ottawa Scale; PTSD = posttraumatic
   stress disorder; PTSS = posttraumatic stress symptoms; VAD = ventricular
   assist device
ID QUALITY-OF-LIFE; CARDIAC-SURGERY; DISEASE; RISK; MORTALITY; OUTCOMES;
   IMPACT
AB Objective
   This study aimed to analyze the longitudinal course of depression, anxiety, and posttraumatic stress disorder (PTSD) symptoms in patients with cardiac disease after heart surgery (HS). Methods
   We conducted a systematic review and random-effects meta-analysis of cohort studies in patients undergoing HS, measuring anxiety, depressive, and PTSD symptoms before and at least 30 days thereafter. Subgroup and meta-regression analyses, investigation of publication bias, and quality assessment were undertaken. Results
   We included 94 studies relating to 15,561 patients. HS included coronary artery bypass graft surgery, valve replacement, implantable cardioverter-defibrillator placement, left ventricular assist device placement, heart transplantation, and other types of HS. Across studies, symptoms of depression (g = 0.32; 95% confidence interval [CI] = 0.25 to 0.39; p < .001) and anxiety improved after HS (g = 0.52; 95% CI = 0.43 to 0.62; p < .001), whereas PTSD symptoms worsened (g = -0.42; 95% CI = -0.80 to -0.04; p = .032). The reduction of depression and anxiety levels was more pronounced for patients with underlying coronary artery disease and heart failure and persisted for 1 year after HS, whereas the increase in PTSD symptoms returned to baseline after 6 months. Depression improvement was inversely associated with older age, diabetes, hypertension, and dyslipidemia and positively with baseline heart failure. No additional clinical or demographic variables were associated with the course of anxiety symptoms. Quality of included studies was low overall. Publication bias was nonsignificant. Conclusions
   Depressive and anxiety symptoms improve for 1 year after HS, whereas PTSD symptoms might worsen. Older patients and those with metabolic comorbidities, valve disease, or ventricular arrhythmias are at higher risk for continued depressive and anxiety symptoms and should be monitored closely.
C1 [Rosson, Stella; Miola, Alessandro; Gentile, Giovanni; Favaro, Angela; Solmi, Marco] Univ Padua, Dept Neurosci, Via Giustiniani 5, I-35100 Padua, Italy.
   [Monaco, Francesco] ASL Salerno, Dept Mental Hlth, Residential Eating Disorder Unit Mariconda, Salerno, Italy.
   [Cascino, Giammarco; Marciello, Francesca] Univ Salerno, Dept Med Surg & Dent, Scuola Med Salernitana, Sect Neurosci, Salerno, Italy.
   [Stubbs, Brendon] South London & Maudsley Natl Hlth Serv Fdn Trust, Physiotherapy Dept, London, England.
   [Stubbs, Brendon] Kings Coll London, Dept Psychol Med, Inst Psychiat Psychol & Neurosci, London, England.
   [Correll, Christoph U.] Northwell Hlth, Dept Psychiat, Zucker Hillside Hosp, Glen Oaks, NY USA.
   [Correll, Christoph U.] Zucker Sch Med Hofstra Northwell, Dept Psychiat & Mol Med, Hempstead, NY USA.
   [Correll, Christoph U.] Feinstein Inst Med Res, Ctr Psychiat Neurosci, Manhasset, NY USA.
   [Correll, Christoph U.] Charite Univ Med Berlin, Dept Child & Adolescent Psychiat, Berlin, Germany.
   [Firth, Joseph] Univ Manchester, Div Psychol & Mental Hlth, Fac Biol Med & Hlth, Manchester, Lancs, England.
   [Firth, Joseph] Univ Western Sydney, NICM Hlth Res Inst, Sch Sci & Hlth, Sydney, NSW, Australia.
   [Firth, Joseph] Univ Melbourne, Ctr Youth Mental Hlth, Melbourne, Vic, Australia.
   [Ermis, Cagatay] Dokuz Eylul Univ, Dept Child & Adolescent Psychiat, Izmir, Turkey.
   [Perrotti, Andrea] Univ Hosp Jean Minjoz, Dept Cardiothorac Surg, Besancon, France.
   [Perrotti, Andrea] Univ Franche Comte, EA 3920, Besancon, France.
   [Carvalho, Andre F.] Univ Toronto, Ctr Addict & Mental Hlth CAMH, Toronto, ON, Canada.
   [Carvalho, Andre F.] Univ Toronto, Dept Psychiat, Toronto, ON, Canada.
   [Brunoni, Andre R.] Ludwig Maximilians Univ Munchen, Univ Hosp, Dept Psychiat & Psychotherapy, Munich, Germany.
   [Brunoni, Andre R.] Univ Sao Paulo, Serv Interdisciplinary Neuromodulat, Dept Psychiat, Lab Neurosci LIM 27, Sao Paulo, Brazil.
   [Brunoni, Andre R.] Univ Sao Paulo, Natl Inst Biomarkers Neuropsychiat INBioN, Inst Psychiat, Sao Paulo, Brazil.
   [Brunoni, Andre R.] Univ Sao Paulo, Fac Med, Univ Hosp, Dept Clin Med, Sao Paulo, Brazil.
   [Fusar-Poli, Paolo; Solmi, Marco] Kings Coll London, Early Psychosis Intervent & Clin Detect EPIC Lab, Dept Psychosis Studies, Inst Psychiat Psychol & Neurosci, London, England.
   [Fusar-Poli, Paolo] South London & Maudsley NHS Fdn Trust, OASIS Serv, London, England.
   [Fusar-Poli, Paolo] Univ Pavia, Dept Brain & Behav Sci, Pavia, Italy.
   [Fusar-Poli, Paolo] South London & Maudsley NHS Fdn Trust, Natl Inst Hlth Res, Maudsley Biomed Res Ctr, London, England.
   [Fornaro, Michele] Univ Sch Med Federico II, Neurosci Reprod Sci & Odontostolmatol, Sect Psychiat, Naples, Italy.
   [Favaro, Angela; Solmi, Marco] Univ Padua, Ctr Neurosci, Padua, Italy.
   [Granziol, Umberto] Univ Padua, Dept Gen Psychol, Padua, Italy.
   [Pigato, Giorgio] Padua Univ Hosp, Psychiat Unit, Padua, Italy.
C3 University of Padua; University of Salerno; South London & Maudsley NHS
   Trust; University of London; King's College London; Northwell Health;
   Northwell Health; Northwell Health; Berlin Institute of Health; Free
   University of Berlin; Humboldt University of Berlin; Charite
   Universitatsmedizin Berlin; University of Manchester; Western Sydney
   University; University of Melbourne; Orygen, The National Centre of
   Excellence in Youth Mental Health; Dokuz Eylul University; Universite de
   Franche-Comte; CHU Besancon; Universite de Franche-Comte; University of
   Toronto; Centre for Addiction & Mental Health - Canada; University of
   Toronto; University of Munich; Universidade de Sao Paulo; Universidade
   de Sao Paulo; Universidade de Sao Paulo; University of London; King's
   College London; South London & Maudsley NHS Trust; University of Pavia;
   South London & Maudsley NHS Trust; University of Naples Federico II;
   University of Padua; University of Padua; University of Padua; Azienda
   Ospedaliera - Universita di Padova
RP Rosson, S (corresponding author), Univ Padua, Dept Neurosci, Via Giustiniani 5, I-35100 Padua, Italy.; Rosson, S (corresponding author), Univ Padua, Dept Neurosci, Via Giustiniani 5, I-35100 Padua, Italy.
EM stella.rosson@gmail.com; fmonaco1980@gmail.com; ale.mio90@hotmail.it;
   gcascino14@gmail.com; brendon.stubbs@kcl.ac.uk; CCorrell@northwell.edu;
   joefirth@gmail.com; ermiscagatay@gmail.com; a.perrotti@hotmail.it;
   francescamarciello81@gmail.com; Andre.Carvalho@camh.ca;
   brunowsky@gmail.com; paolo.fusar-poli@kcl.ac.uk; dott.fornaro@gmail.com;
   giovanni.gentile@unipd.it; umberto.granziol@phd.unipd.it;
   giorgio.pigato@aopd.veneto.it; angela.favaro@unipd.it;
   Marco.solmi83@gmail.com
RI Cascino, Giammarco/HWQ-4669-2023; Carvalho, Andre/AEZ-4001-2022;
   GRANZIOL, UMBERTO/ISB-5815-2023; solmi, marco/K-3906-2018; Miola,
   Alessandro/LMP-0749-2024; Gentile, Giovanni/AAY-3281-2021; Correll,
   Christoph/D-3530-2011; Firth, Joseph/JOZ-1679-2023; Stubbs,
   Brendon/X-1904-2018; Russowsky Brunoni, Andre/H-8394-2012; Stubbs,
   Brendon/C-5696-2015; Fusar-Poli, Paolo/D-8605-2011; Favaro,
   Angela/J-2966-2012; Monaco, Francesco/ADD-7161-2022
OI Russowsky Brunoni, Andre/0000-0002-6310-3571; solmi,
   marco/0000-0003-4877-7233; Stubbs, Brendon/0000-0001-7387-3791; Cascino,
   Giammarco/0000-0003-0358-8594; Fusar-Poli, Paolo/0000-0003-3582-6788;
   Gentile, Giovanni/0000-0001-6393-2655; Favaro,
   Angela/0000-0002-6540-5194; Rosson, Stella/0000-0002-8554-3519; Monaco,
   Francesco/0000-0002-1854-292X; Correll, Christoph U/0000-0002-7254-5646
FU Janssen; Takeda; Scientific and Technological Research Council of Turkey
   (TUBITAK); University of Manchester Presidential Fellowship [P123958];
   UK Research and Innovation Future Leaders Fellowship [MR/T021780/1];
   Lundbeck
FX S.R., F.Mo., A.M., G.C., B.S., A.P., F. Ma., A.F.C., A. R.B., M.F.,
   G.G., U.G., G.P., and A.F. have no conflict of interest to declare.
   C.U.C. has been a consultant and/or advisor to or has received honoraria
   from the following: Alkermes, Allergan, Angelini, Gedeon Richter, Gerson
   Lehrman Group, IntraCellular Therapies, Janssen/J&J, LB Pharma,
   Lundbeck, MedAvante-ProPhase, Medscape, Neurocrine, Noven, Otsuka,
   Pfizer, Recordati, Rovi, Sumitomo Dainippon, Sunovion, Supernus, Takeda,
   and Teva. He has provided expert testimony for Janssen and Otsuka. He
   served on a Data Safety Monitoring Board for Lundbeck, Rovi, Supernus,
   and Teva. He received royalties from UpToDate and grant support from
   Janssen and Takeda. He is also a stock option holder of LB Pharma. C.E.
   was supported by a grant from The Scientific and Technological Research
   Council of Turkey (TUBITAK). J.F. is supported by a University of
   Manchester Presidential Fellowship (P123958) and a UK Research and
   Innovation Future Leaders Fellowship (MR/T021780/1). P.F.-P. has
   received honoraria from Lundbeck and Menarini and grant support from
   Lundbeck. M.S. received honoraria as consultant/advisor in advisory
   boards and/or for talks/presentations from Angelini and Lundbeck. This
   research received no specific grant from any funding agency, or
   commercial or not-for-profit sectors.
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NR 50
TC 16
Z9 16
U1 1
U2 14
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0033-3174
EI 1534-7796
J9 PSYCHOSOM MED
JI Psychosom. Med.
PD JAN
PY 2021
VL 83
IS 1
BP 85
EP 93
DI 10.1097/PSY.0000000000000872
PG 9
WC Psychiatry; Psychology; Psychology, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry; Psychology
GA QE8SS
UT WOS:000616476000009
PM 33021524
OA Green Published
DA 2025-06-11
ER

PT J
AU Blanchard, MS
   Eisen, SA
   Alpern, R
   Karlinsky, J
   Toomey, R
   Reda, DJ
   Murphy, FM
   Jackson, LW
   Kang, HK
AF Blanchard, MS
   Eisen, SA
   Alpern, R
   Karlinsky, J
   Toomey, R
   Reda, DJ
   Murphy, FM
   Jackson, LW
   Kang, HK
TI Chronic multisymptom illness complex in Gulf War I veterans 10 years
   later
SO AMERICAN JOURNAL OF EPIDEMIOLOGY
LA English
DT Article
DE Gulf War; metabolic syndrome X; Persian Gulf syndrome; quality of life;
   risk factors; stress; psychological; veterans
ID NEUROMUSCULAR SYMPTOMS; RISK-FACTORS; HEALTH; ASSOCIATION; DISORDERS;
   MORTALITY; SERVICE; STRESS
AB Prior research has demonstrated that shortly after the 1991 Gulf War (Gulf War I), chronic multisymptom illness (CMI) was more common among deployed veterans than among nondeployed veterans. The aims of the current study were to determine the prevalence of CMI among deployed and nondeployed veterans 10 years after Gulf War I, compare the distribution of comorbid conditions, and identify prewar factors associated with CMI. Cross-sectional data collected from 1,061 deployed veterans and 1,128 nondeployed veterans examined between 1999 and 2001 were analyzed. CMI prevalence was 28.9% among deployed veterans and 15.8% among nondeployed veterans (odds ratio = 2.16, 95% confidence interval: 1.61, 2.90). Deployed and nondeployed veterans with CMI had similarly poorer quality-of-life measures and higher prevalences of symptom-based medical conditions, metabolic syndrome, and psychiatric disorders. Diagnoses of prewar anxiety disorders (not related to post-traumatic stress disorder) and depression were associated with CMI among both deployed and nondeployed veterans. Nicotine dependence and veteran-reported physician-diagnosed infectious mononucleosis were associated with CMI among deployed veterans, and migraine headaches and gastritis were associated with CMI among nondeployed veterans. CMI continues to be substantially more prevalent among deployed veterans than among nondeployed veterans 10 years after Gulf War I, but it manifests similarly in both groups. It is likely to be a common, persistent problem among veterans returning from the current Gulf War.
C1 St Louis Vet Affairs Med Ctr, Med Serv, St Louis, MO 63106 USA.
   St Louis Vet Affairs Med Ctr, Res Serv, St Louis, MO 63106 USA.
   Washington Univ, Sch Med, Dept Internal Med, St Louis, MO 63110 USA.
   US Dept Vet Affairs, Vet Affairs Edward Hines Jr Hosp, Cooperat Studies Program Coordinating Ctr, Hines, IL 60141 USA.
   VA Boston Healthcare Syst, Boston, MA USA.
   Boston Univ, Sch Med, Dept Med, Div Pulm & Crit Care Med, W Roxbury, MA USA.
   Harvard Univ, Sch Med, Dept Psychiat, Massachusetts Mental Hlth Ctr, Boston, MA 02115 USA.
   Harvard Univ, Sch Publ Hlth, Inst Psychiat Epidemiol & Genet, Boston, MA 02115 USA.
   Harvard Univ, Sch Med, Boston, MA 02115 USA.
   Dept Vet Affairs, Cent Off, Washington, DC USA.
   Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA.
   Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Baltimore, MD USA.
   Dept Vet Affairs, Environm Epidemiol Serv, Washington, DC USA.
   George Washington Univ, Sch Publ Hlth & Hlth Serv, Washington, DC USA.
C3 Washington University (WUSTL); US Department of Veterans Affairs;
   Veterans Health Administration (VHA); Edward Hines Jr. VA Hospital;
   Harvard University; Harvard University Medical Affiliates; US Department
   of Veterans Affairs; Veterans Health Administration (VHA); VA Boston
   Healthcare System; Boston University; Harvard University; Harvard
   Medical School; Harvard University; Harvard T.H. Chan School of Public
   Health; Harvard University; Harvard Medical School; Uniformed Services
   University of the Health Sciences - USA; Johns Hopkins University; Johns
   Hopkins Bloomberg School of Public Health; George Washington University
RP St Louis Vet Affairs Med Ctr, Med Serv, 111-JC,915 N Grand Ave, St Louis, MO 63106 USA.
EM melvin.blanchard@med.va.gov
RI kang, han/KIC-4795-2024
OI Eisen, Seth/0000-0001-7746-6624; , Domenic/0000-0003-1831-4270
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NR 46
TC 102
Z9 108
U1 0
U2 8
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0002-9262
EI 1476-6256
J9 AM J EPIDEMIOL
JI Am. J. Epidemiol.
PD JAN 1
PY 2006
VL 163
IS 1
BP 66
EP 75
DI 10.1093/aje/kwj008
PG 10
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA 997CS
UT WOS:000234223200008
PM 16293719
OA Bronze
DA 2025-06-11
ER

PT J
AU Tang, ZY
   Zhen, YP
   Zhang, L
   Liu, XB
   Ma, J
AF Tang, Zhongyu
   Zhen, Yanping
   Zhang, Lin
   Liu, Xuebing
   Ma, Jun
TI Prevalence and factors associated with metabolic syndrome in first
   hospitalization for major depression disorder patients
SO SCIENTIFIC REPORTS
LA English
DT Article
ID THYROID-FUNCTION; BIPOLAR DISORDER; RISK; SYMPTOMS; LIFE; SCHIZOPHRENIA;
   COMPONENTS; ANXIETY
AB Major depressive disorder (MDD) is a common and socially burdensome psychiatric disorder with a causal and complex relationship with metabolic syndrome (MetS), which is often co-morbid. However, the prevalence and risk factors for MetS in patients with MDD are inconclusive. The purpose of this study is to investigate the prevalence and factors influencing MetS in first hospitalization MDD patients. A total of 981 MDD patients were included. Sociodemographic and general clinical data were collected from the patients, while metabolism-related parameters were also measured, and psychological symptoms were assessed. Our study found that the prevalence of MetS in the study population was 9.68%. MDD patients with MetS had higher levels of metabolism-related parameters and more severe psychological symptoms. We identified risk factors for MetS and its severity separately: age of onset of MDD, more severe depressive symptoms, and higher thyroid stimulating hormone (TSH) levels were risk factors for the development of MetS, whereas higher TSH levels were risk factors for the severity of MetS. Our results suggest that MetS is not highly prevalent in MDD patients, but certain risk factors may increase its likelihood and severity, and that these findings could be beneficial for clinical intervention and care of MetS.
C1 [Tang, Zhongyu; Zhang, Lin; Liu, Xuebing; Ma, Jun] Wuhan Mental Hlth Ctr, Dept Psychiat, 89 Gongnongbing Rd, Wuhan, Hubei, Peoples R China.
   [Tang, Zhongyu; Zhang, Lin; Liu, Xuebing; Ma, Jun] Wuhan Hosp Psychotherapy, Wuhan, Peoples R China.
   [Zhen, Yanping] Hubei Univ Sci & Technol, Affiliated Hosp 2, Dept Psychiat, Xianning, Peoples R China.
C3 Hubei University of Science & Technology
RP Liu, XB; Ma, J (corresponding author), Wuhan Mental Hlth Ctr, Dept Psychiat, 89 Gongnongbing Rd, Wuhan, Hubei, Peoples R China.; Liu, XB; Ma, J (corresponding author), Wuhan Hosp Psychotherapy, Wuhan, Peoples R China.
EM 107768791@qq.com; majun0313@msn.cn
RI Ma, Jun/HLV-7600-2023
FU scientific research project of Wuhan Municipal Health Commission
   [WG20D12]
FX We are grateful to all the medical staffs and patients in our study and
   to those who contributed to the diagnosis and clinical evaluation of the
   subjects. This study was funded by the scientific research project of
   Wuhan Municipal Health Commission (WG20D12, Zhongyu Tang, PI).
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NR 47
TC 3
Z9 3
U1 0
U2 5
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD SEP 19
PY 2023
VL 13
IS 1
AR 15496
DI 10.1038/s41598-023-42720-y
PG 7
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA W1ES9
UT WOS:001089134700054
PM 37726320
OA Green Submitted, gold, Green Published
DA 2025-06-11
ER

PT J
AU Cubbon, RM
   Kahn, MB
   Wheatcroft, SB
AF Cubbon, Richard M.
   Kahn, Matthew B.
   Wheatcroft, Stephen B.
TI Effects of insulin resistance on endothelial progenitor cells and
   vascular repair
SO CLINICAL SCIENCE
LA English
DT Review
DE cardiometabolic risk; endothelial progenitor cell (EPC); insulin
   resistance; obesity; metabolic syndrome; Type 2 diabetes
ID NITRIC-OXIDE SYNTHASE; COLONY-STIMULATING FACTOR; ACUTE
   MYOCARDIAL-INFARCTION; CORONARY-ARTERY-DISEASE; BONE-MARROW-CELLS;
   GROWTH-FACTOR-I; PERIPHERAL-BLOOD; METABOLIC-SYNDROME;
   DIABETES-MELLITUS; GLUCOSE-TOLERANCE
AB Insulin resistance, a key feature of obesity, the metabolic syndrome and Type 2 diabetes mellitus, results in an array of metabolic and vascular phenomena which ultimately promote the development of atherosclerosis. Endothelial dysfunction is intricately related to insulin resistance through the parallel stimulatory effects of insulin on glucose disposal in metabolic tissues and NO production in the endothelium. Perturbations characteristic of insulin resistance, including dyslipidaemia, inflammation and oxidative stress, may jeopardize the structural or functional integrity of the endothelium. Recent evidence suggests that endothelial damage is mitigated by endogenous reparative processes which mediate endothelial regeneration. EPCs (endothelial progenitor cells) are circulating cells which have been identified as mediators of endothelial repair. Several of the abnormalities associated with insulin resistance, including reduced NO bioavailability, increased production of ROS (reactive oxygen species) and down-regulation of intracellular signalling pathways, have the potential to disrupt EPC function. Improvement in the number and function of EPCs may contribute to the protective actions of evidence-based therapies to reduce cardiometabolic risk. In the present article, we review the putative effects of insulin resistance on EPCs, discuss the underlying mechanisms and highlight potential therapeutic manoeuvres which could improve vascular repair in individuals with insulin resistance.
C1 [Wheatcroft, Stephen B.] Univ Leeds, Div Cardiovasc & Diabet Res, LIGHT, Leeds LS2 9JT, W Yorkshire, England.
   Univ Leeds, Multidisciplinary Cardiovasc Res Ctr, Leeds LS2 9JT, W Yorkshire, England.
C3 University of Leeds; University of Leeds
RP Wheatcroft, SB (corresponding author), Univ Leeds, Div Cardiovasc & Diabet Res, LIGHT, Leeds LS2 9JT, W Yorkshire, England.
EM s.b.wheatcroft@leeds.ac.uk
FU British Heart Foundation; Diabetes UK
FX The authors' work is supported by the British Heart Foundation and
   Diabetes UK.
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   Zeng GY, 1996, J CLIN INVEST, V98, P894, DOI 10.1172/JCI118871
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   Zhu WD, 2008, CLIN SCI, V114, P361, DOI 10.1042/CS20070347
NR 185
TC 58
Z9 71
U1 0
U2 13
PU PORTLAND PRESS LTD
PI LONDON
PA 5TH FLR, 90 HIGH HOLBORN, LONDON WC1V 6LJ, ENGLAND
SN 0143-5221
EI 1470-8736
J9 CLIN SCI
JI Clin. Sci.
PD SEP
PY 2009
VL 117
IS 5-6
BP 173
EP 190
DI 10.1042/CS20080263
PG 18
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 492GU
UT WOS:000269643900001
PM 19630751
DA 2025-06-11
ER

PT J
AU John, A
   Desai, R
   Richards, M
   Gaysina, D
   Stott, J
AF John, Amber
   Desai, Roopal
   Richards, Marcus
   Gaysina, Darya
   Stott, Joshua
TI Role of cardiometabolic risk in the association between accumulation of
   affective symptoms across adulthood and mid-life cognitive function:
   national cohort study
SO BRITISH JOURNAL OF PSYCHIATRY
LA English
DT Article
DE Depression; anxiety; cognitive ageing; cardiometabolic health;
   longitudinal; birth cohort
ID PSYCHOLOGICAL DISTRESS; ALZHEIMERS-DISEASE; DEMENTIA; DEPRESSION;
   DISORDERS
AB Background
   Affective symptoms are associated with cognition in mid-life and later life. However, the role of cardiometabolic risk in this association has not been previously examined.
   Aims
   To investigate how cardiometabolic risk contributes to associations between affective symptoms and mid-life cognition.
   Method
   Data were used from the National Child Development Study (NCDS), a sample of people born in Britain during one week in 1958. Measures of immediate and delayed memory, verbal fluency and information processing speed and accuracy were available at age 50. Affective symptoms were assessed at ages 23, 33 and 42 years and a measure of accumulation was derived. A cardiometabolic risk score was calculated from nine cardiometabolic biomarkers at age 44. Path models were run to test these associations, adjusting for sex, education, socioeconomic position and affective symptoms at age 50.
   Results
   After accounting for missing data using multiple imputation, path models indicated significant indirect associations between affective symptoms and mid-life immediate memory (beta = -0.002, s.e. = 0.001, P = 0.009), delayed memory (beta = -0.002, s.e. = 0.001, P = 0.02) and verbal fluency (beta = -0.002, s.e. = 0.001, P = 0.045) through cardiometabolic risk.
   Conclusions
   These findings suggest that cardiometabolic risk may play an important role in the association between affective symptoms and cognitive function (memory and verbal fluency). Results contribute to understanding of biological mechanisms underlying associations between affective symptoms and cognitive ageing, which can have implications for early detection of, and intervention for, those at risk of poorer cognitive outcomes.
C1 [John, Amber; Desai, Roopal; Stott, Joshua] UCL, Res Dept Clin Educ & Hlth Psychol, London, England.
   [Richards, Marcus] UCL, MRC Unit Lifelong Hlth & Ageing, London, England.
   [Gaysina, Darya] Univ Sussex, Sch Psychol, EDGE Lab, Brighton, E Sussex, England.
C3 University of London; University College London; University of London;
   University College London; University of Sussex
RP John, A (corresponding author), UCL, Res Dept Clin Educ & Hlth Psychol, London, England.
EM a.john@ucl.ac.uk
RI stott, josh/AAX-6275-2021
OI Stott, Joshua/0000-0003-1361-053X; Richards, Marcus/0000-0001-9191-2192;
   Desai, Roopal/0000-0003-4221-1546; John, Amber/0000-0002-8207-7698
FU Economic and Social Research Council (ESRC) [ES/J500173/1]; Alzheimer's
   Society [AS-PG-18-013]; ESRC [ES/M001660/1]; Wellcome Trust; Medical
   Research Council (MRC) [MR/N01104X/1, ES/S008349/1]; MRC
   [108439/Z/15/Z]; Medical Research Council 58READIE Project [WT095219MA,
   G1001799]; ESRC [ES/S008349/1] Funding Source: UKRI; MRC [MC_UU_00019/3]
   Funding Source: UKRI
FX Economic and Social Research Council (ESRC) (D.G., A.J.: grant number:
   ES/J500173/1). Alzheimer's Society (J.S., R.D., A.J., M.R.: MODIFY
   Project, grant number AS-PG-18-013). Data governance was provided by the
   METADAC data access committee, funded by the ESRC, Wellcome Trust and
   Medical Research Council (MRC) (2015-2018: grant number MR/N01104X/1;
   2018-2020: grant number ES/S008349/1). Data and samples generated by the
   NCDS 1958 Birth Cohort is managed by the Centre for Longitudinal Studies
   at the UCL Institute of Education, funded by the ESRC (grant number
   ES/M001660/1). Access to these resources was enabled via the Wellcome
   Trust and MRC (58FORWARDS grant 108439/Z/15/Z). Before 2015 biomedical
   resources were maintained under the Wellcome Trust and Medical Research
   Council 58READIE Project (grant numbers WT095219MA and G1001799).
   Funders were not involved in the study design; collection, analysis, and
   interpretation of data; writing the report; or in the decision to submit
   the article for publication.
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NR 25
TC 8
Z9 8
U1 0
U2 2
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1250
EI 1472-1465
J9 BRIT J PSYCHIAT
JI Br. J. Psychiatry
PD MAY
PY 2021
VL 218
IS 5
BP 254
EP 260
AR PII S0007125020001233
DI 10.1192/bjp.2020.123
PG 7
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA RU0TY
UT WOS:000644866600007
PM 32662372
OA Green Accepted, Green Submitted
DA 2025-06-11
ER

PT J
AU Macgregor, AP
   Borghese, MM
   Janssen, I
AF Macgregor, Anne P.
   Borghese, Michael M.
   Janssen, Ian
TI Is replacing time spent in 1 type of physical activity with another
   associated with health in children?
SO APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
LA English
DT Article
DE behaviour; fat mass; mathematical modelling; epidemiology; physical
   activity; pediatrics
ID YOUTH; INTENSITY; FITNESS; PLAY
AB Altering the proportion of total physical activity time accumulated while participating in different types of physical activity may influence health. Our objective was to use observational data to estimate whether replacing time from 1 type of physical activity with another is associated with physical and mental health indicators among children. Participants were 385 children aged 10-13 years. They wore a Global Positioning System watch and accelerometer and completed an activity log for 7 days. Data from these instruments was used to estimate time spent in outdoor active play, organized sport, curriculum-based physical activity at school, and active transportation. A cardiometabolic risk factor score was created from body fat, resting heart rate, and resting blood pressure measures. An internalizing symptoms score was created using anxiety and depression symptom questionnaire items. Isotemporal substitution models estimated if health indicators changed when time in 1 type of physical activity was replaced with equivalent time from another. The results indicated that time spent in all types of physical activity combined was associated with the cardiometabolic risk factor and internalizing symptom scores. Replacing active transportation with outdoor active play was associated with an increase in the internalizing symptoms score but a decrease in the cardiometabolic risk factor score. The internalizing symptoms score decreased when active transportation was replaced by equivalent time in organized sport. Other time substitutions were not significant. In conclusion, the total time spent participating in physical activity and not a specific type of physical activity was the most consistent correlate of the health indicators.
C1 [Macgregor, Anne P.; Borghese, Michael M.; Janssen, Ian] Queens Univ, Sch Kinesiol & Hlth Studies, Kingston, ON K7L 3N6, Canada.
   [Janssen, Ian] Queens Univ, Dept Publ Hlth Sci, Kingston, ON, Canada.
C3 Queens University - Canada; Queens University - Canada
RP Janssen, I (corresponding author), Queens Univ, Sch Kinesiol & Hlth Studies, Kingston, ON K7L 3N6, Canada.; Janssen, I (corresponding author), Queens Univ, Dept Publ Hlth Sci, Kingston, ON, Canada.
EM ian.janssen@queensu.ca
RI Janssen, Ian/B-7700-2009
OI Janssen, Ian/0000-0003-2159-3012
FU Heart and Stroke Foundation of Canada
FX This study was funded by a grant-in-aide from the Heart and Stroke
   Foundation of Canada. The authors would like to thank the participants
   for their commitment to the study and the many graduate and
   undergraduate students who assisted with data collection and cleaning.
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NR 26
TC 7
Z9 7
U1 1
U2 23
PU CANADIAN SCIENCE PUBLISHING
PI OTTAWA
PA 65 AURIGA DR, SUITE 203, OTTAWA, ON K2E 7W6, CANADA
SN 1715-5312
EI 1715-5320
J9 APPL PHYSIOL NUTR ME
JI Appl. Physiol. Nutr. Metab.
PD SEP
PY 2019
VL 44
IS 9
BP 937
EP 943
DI 10.1139/apnm-2018-0323
PG 7
WC Nutrition & Dietetics; Physiology; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics; Physiology; Sport Sciences
GA IT7VU
UT WOS:000483088200003
PM 30653335
DA 2025-06-11
ER

PT J
AU Aboonabi, A
   Meyer, RR
   Gaiz, A
   Singh, I
AF Aboonabi, Anahita
   Meyer, Roselyn Rose
   Gaiz, Almottesembellah
   Singh, Indu
TI Anthocyanins in berries exhibited anti-atherogenicity and antiplatelet
   activities in a metabolic syndrome population
SO NUTRITION RESEARCH
LA English
DT Article
ID C-REACTIVE PROTEIN; OXIDATIVE STRESS; PLATELET ACTIVATION; SUBCLINICAL
   ATHEROSCLEROSIS; DIETARY POLYPHENOLS; INSULIN-RESISTANCE;
   ALPHA-GLUCOSIDASE; NITRIC-OXIDE; P-SELECTIN; URIC-ACID
AB Metabolic syndrome (MetS) is a global challenge for atherosclerosis. It was hypothesized that a four-week consumption of anthocyanin supplements by MetS patients who had three or more risk factors linked with metabolic syndrome would have a greater improvement in cardiometabolic biomarkers and would also reduce the risk of thrombosis. A total of 55 participants in two groups of Normal healthy and MetS (age 25-75y) were given 320 mg anthocyanin supplements twice daily for 4 weeks. Platelet coagulant activities, lipid profiles, fasting blood glucose, and inflammatory and oxidative stress biomarkers were measured before and after supplementation to evaluate the atheroprotective effects of anthocyanins in the study subjects. Four weeks of anthocyanin supplementation significantly decreased cardiometabolic risk factors including the average serum fasting blood glucose (FBG) (by 13.3%, P < .05) and lipid profiles by significant reduction in triglyceride (by 24.9%, P < .05) and LDL-C (by 33.1%, P < .05) in the MetS group. Anthocyanin supplementation also decreased high sensitivity C-reactive protein (hs-CRP) level (by 28%, P < .05) in females. However, no significant differences in serum UA (uric acid) and HDL-C were observed between anthocyanin pre- and post-treatment in both groups. Moreover, Anthocyanin supplements decreased ADP-induced platelet activation configuration expressed as P-selectin by 40% (P < .05). There was a positive correlation between decreased hs-CRP values and the levels of LDL-C and FBG in the MetS group (P < .05). These results support the hypothesis that anthocyanin supplementation exerts anti-atherogenicity effects by improving cardiometabolic risk factors and reducing thrombogenicity in the MetS population. (C) 2020 Elsevier Inc. All rights reserved.
C1 [Aboonabi, Anahita; Meyer, Roselyn Rose; Gaiz, Almottesembellah; Singh, Indu] Sch Med Sci, Gold Coast Campus,Parklands Dr, Southport, Qld 4222, Australia.
RP Aboonabi, A (corresponding author), Sch Med Sci, Gold Coast Campus,Parklands Dr, Southport, Qld 4222, Australia.
EM anahita.aboonabi@griffithuni.edu.au; r.rosemyer@griffith.edu.au;
   Almottesembellah.gaiz@griffith.edu.au; i.singh@griffith.edu.au
RI GAIZ, ALMOTTESEMBELLAH/JZS-9831-2024
OI Aboonabi, Anahita/0000-0001-6213-6673; Singh, Indu/0000-0002-0498-4209;
   Gaiz, Almottesembellah/0000-0003-1528-9356
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NR 59
TC 39
Z9 40
U1 0
U2 21
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0271-5317
J9 NUTR RES
JI Nutr. Res.
PD APR
PY 2020
VL 76
BP 82
EP 93
DI 10.1016/j.nutres.2020.02.011
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA LL5FV
UT WOS:000531584200008
PM 32217379
DA 2025-06-11
ER

PT J
AU Golding, H
   Ritonja, JA
   Day, AG
   Aronson, KJ
   Tranmer, J
AF Golding, Haley
   Ritonja, Jennifer A.
   Day, Andrew G.
   Aronson, Kristan J.
   Tranmer, Joan
TI Modeling the relationship between shift work and cardiometabolic risk
   through circadian disruption, sleep and stress pathways
SO CHRONOBIOLOGY INTERNATIONAL
LA English
DT Article
DE Shift work; circadian disruption; cardiovascular risk; mechanistic
   pathways; metabolic syndrome
ID METABOLIC SYNDROME; CARDIOVASCULAR RISK; CORTISOL PRODUCTION;
   ASSOCIATION; DURATION; QUALITY; NURSES
AB The purpose of this study is to elucidate the multiple pathways linking shift work exposure to cardiometabolic risk (CMR) through the intermediates of circadian disruption, sleep disturbances, and stress. A cross-sectional study was conducted at Kingston Health Sciences Center that included female hospital workers, 160 who worked a day-only schedule and 168 who worked rotating days and nights. Participants completed questionnaires, a clinical exam, and wore accelerometers to collect sleep data for 8 days. Participants also collected urine samples at each void during a 24-h collection period, on the day shift for day-only workers and the night shift for rotating shift workers, for cortisol and melatonin measures. We adapted and tested a conceptual model proposed by Knutsson and Boggild for circadian disruption, sleep, and stress mechanistic pathways linking shift work to CMR using structural equation modeling techniques. Status as a rotating shift worker was associated with increased circadian disruption of cortisol and melatonin production compared to day-only workers (P < .001). Increased circadian disruption was associated with an increased CMR (P = .01). Rotating shift work was associated with sleep disturbances (P = .002) and increased job stress (P < .001), but neither was associated with CMR. We conclude that rotating shift work is associated indirectly with increased CMR. This association is mediated by circadian disruption as indicated by attenuated melatonin and cortisol, and flatter cortisol curves.
C1 [Golding, Haley; Ritonja, Jennifer A.; Day, Andrew G.; Aronson, Kristan J.; Tranmer, Joan] Queens Univ, Dept Publ Hlth Sci, Kingston, ON, Canada.
   [Aronson, Kristan J.] Queens Univ, Canc Res Inst, Kingston, ON, Canada.
   [Tranmer, Joan] Queens Univ, Sch Nursing, 92 Barrie St, Kingston, ON K7L 3N6, Canada.
C3 Queens University - Canada; Queens University - Canada; Queens
   University - Canada
RP Tranmer, J (corresponding author), Queens Univ, Sch Nursing, 92 Barrie St, Kingston, ON K7L 3N6, Canada.
EM tranmerj@queensu.ca
RI Ritonja, Jennifer/ADS-5126-2022
OI Tranmer, Joan/0000-0001-5192-5992; Day, Andrew/0000-0002-1095-5703;
   Golding, Haley/0000-0001-5912-5869
FU Canadian Institute for Health Research; Workplace Safety and Insurance
   Board (Ontario)
FX This study was funded by the Canadian Institute for Health Research and
   the Workplace Safety and Insurance Board (Ontario).
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NR 41
TC 4
Z9 4
U1 3
U2 10
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 0742-0528
EI 1525-6073
J9 CHRONOBIOL INT
JI Chronobiol. Int.
PD MAY 4
PY 2022
VL 39
IS 5
BP 704
EP 713
DI 10.1080/07420528.2022.2032124
EA JAN 2022
PG 10
WC Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics; Physiology
GA 1D9ZB
UT WOS:000749369900001
PM 35100920
DA 2025-06-11
ER

PT J
AU Teixeira, PJR
   Rochal, FL
AF Ribeiro Teixeira, Paulo Jose
   Rochal, Fabio Lopes
TI The prevalence of metabolic syndrome among psychiatric inpatients in
   Brazil
SO REVISTA BRASILEIRA DE PSIQUIATRIA
LA English
DT Article
DE metabolic syndrome X; mental disorders; schizophrenia; bipolar disorder;
   depression
ID 3RD NATIONAL-HEALTH; ALCOHOL-CONSUMPTION; YOUNG-ADULTS; RISK-FACTORS;
   SCHIZOPHRENIA; DYSLIPIDEMIA; DEFINITION; DISORDER; US
AB Objective: Metabolic syndrome is a highly prevalent disorder among the general population. Studies show an even higher prevalence among psychiatric patients. The objective of this study is to assess the prevalence of metabolic syndrome among inpatients of a psychiatric ward of a general hospital in Brazil and correlate it with their respective psychiatric diagnoses and with the antipsychotics and mood stabilizers used. Method: 170 inpatients (mean age: 45.6 years) were evaluated according to the National Cholesterol Education Program criteria for metabolic syndrome, with a modification of the criteria for blood pressure and fasting glucose. Results: The prevalence found was 29.4%, being higher in women (43.6% versus 20.8%, p = 0.002). The prevalence stratified by psychiatric diagnostic was 48.1% for depression, 38.3% for bipolar disorder 31.8% for schizophrenia and schizoaffective disorder, 5.1% for alcoholism, and 23.1% for "other mental disorders". The prevalence for alcoholism was significantly lower than the prevalence rates associated with other diagnostic categories (p = 0.035). After using the multivariate analysis, female gender and use of lithium remained as factors associated with a diagnosis of metabolic syndrome. Conclusions: The prevalence found was 29.4%. Gender (female) and use of lithium were factors significantly associated with the diagnosis of metabolic syndrome.
C1 [Ribeiro Teixeira, Paulo Jose; Rochal, Fabio Lopes] IPSEMG, Belo Horizonte, MG, Brazil.
RP Teixeira, PJR (corresponding author), Rua Fernandes Tourinho,470-Sala 903-Savassi, BR-30112000 Belo Horizonte, MG, Brazil.
EM teixeirapaulo@uol.com.br
RI Rocha, Fabio/B-7753-2008
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NR 35
TC 88
Z9 99
U1 0
U2 5
PU ASSOC BRASILEIRA PSIQUIATRIA
PI SAO PAULO
PA SUBSCRIPTION DEPARTMENT, RUA PEDRO DE TOLEDO, 967 - CASA 01, SAO PAULO,
   SP 04039-032  A, BRAZIL
EI 1809-452X
J9 REV BRAS PSIQUIATR
JI Rev. Bras. Psiquiatr.
PD DEC
PY 2007
VL 29
IS 4
BP 330
EP 336
DI 10.1590/S1516-44462007000400007
PG 7
WC Psychiatry
WE Social Science Citation Index (SSCI)
SC Psychiatry
GA 244PM
UT WOS:000251877800007
PM 18200397
OA gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Pintor, JK
   Mitchell, DC
   Schenker, MB
AF Pintor, Jessie Kemmick
   Mitchell, Diane C.
   Schenker, Marc B.
TI Exploring the Role of Depression as a Moderator of a Workplace Obesity
   Intervention for Latino Immigrant Farmworkers
SO JOURNAL OF IMMIGRANT AND MINORITY HEALTH
LA English
DT Article
DE Migrant farmworkers; Latino immigrants; Obesity; Mental health;
   Intervention
ID FOOD INSECURITY; WEIGHT-LOSS; METABOLIC SYNDROME; INCREASED RISK;
   MENTAL-HEALTH; SHORT-FORM; MIGRANT; US; MAINTENANCE; CALIFORNIA
AB We explored if and how depression moderated the treatment effect of Pasos Saludables, a successful pilot workplace obesity intervention for Latino immigrant farmworkers. The original randomized controlled study assigned 254 participants 2:1 to a 10-session educational intervention versus control. We assessed the relationship between change in BMI (primary outcome) and interaction of treatment allocation and baseline risk for depression. Baseline CES-D scores indicated that 27.3% of participants were at risk for depression. The interaction between treatment allocation and baseline risk for depression was significant (p=0.004). In adjusted modelsamong women, intervention participants with no indication of depression at baseline reduced their BMI by 0.77 on average (95% CI -1.25, -0.30) compared to controls. The reduction im BMI between the intervention group at risk for depression at baselineand eithercontrol was not significantly different from zero. Findings from our post-hoc, exploratory study indicate that depression may inhibit significant weight loss.
C1 [Pintor, Jessie Kemmick; Mitchell, Diane C.; Schenker, Marc B.] Univ Calif Davis, Dept Publ Hlth Sci, Davis, CA 95616 USA.
   [Pintor, Jessie Kemmick] Drexel Univ, Dept Hlth Management & Policy, Dornsife Sch Publ Hlth, 3215 Market St Room 352, Philadelphia, PA 19104 USA.
   [Pintor, Jessie Kemmick] Univ Calif Davis, Ctr Hlth & Environm, 1250 Old Davis Rd, Davis, CA 95616 USA.
C3 University of California System; University of California Davis; Drexel
   University; University of California System; University of California
   Davis
RP Pintor, JK (corresponding author), Univ Calif Davis, Dept Publ Hlth Sci, Davis, CA 95616 USA.; Pintor, JK (corresponding author), Drexel Univ, Dept Hlth Management & Policy, Dornsife Sch Publ Hlth, 3215 Market St Room 352, Philadelphia, PA 19104 USA.; Pintor, JK (corresponding author), Univ Calif Davis, Ctr Hlth & Environm, 1250 Old Davis Rd, Davis, CA 95616 USA.
EM jbp83@drexel.edu
FU Reiter Affiliated Companies LLC (RAC); NIOSH Grant [U54 OH007550];
   Agency for Healthcare Research and Quality (AHRQ) [T32 HS022236]
FX We extend our gratitude to study staff and participants without whom the
   pilot study and the work presented here would not have been possible.
   Reiter Affiliated Companies LLC (RAC) provided the majority of the grant
   funding for the pilot study, and study participants were all RAC
   workers. A contract was enacted between RAC and UC Davis, which ensured
   confidentiality for the participants and that the university retained
   the right to data and publishing independent to RAC. This study was
   supported by NIOSH Grant U54 OH007550 (the Western Center for
   Agricultural Health and Safety) and Agency for Healthcare Research and
   Quality (AHRQ) training Grant T32 HS022236. NIOSH, AHRQ, and RAC had no
   involvement in the study design, analysis and interpretation of data, or
   writing and submission of this manuscript. The content is solely the
   responsibility of the authors and does not necessarily represent the
   official views of NOISH, ARHQ, or RAC.
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NR 59
TC 3
Z9 4
U1 0
U2 14
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1557-1912
EI 1557-1920
J9 J IMMIGR MINOR HEALT
JI J. Immigr. Minor. Health
PD APR
PY 2019
VL 21
IS 2
BP 383
EP 392
DI 10.1007/s10903-018-0743-4
PG 10
WC Public, Environmental & Occupational Health
WE Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA HU6TG
UT WOS:000465413100021
PM 29737446
DA 2025-06-11
ER

PT J
AU Brailean, A
   Curtis, J
   Davis, K
   Dregan, A
   Hotopf, M
AF Brailean, Anamaria
   Curtis, Jessica
   Davis, Katrina
   Dregan, Alexandru
   Hotopf, Matthew
TI Characteristics, comorbidities, and correlates of atypical depression:
   evidence from the UK Biobank Mental Health Survey
SO PSYCHOLOGICAL MEDICINE
LA English
DT Article
DE Adverse life events; atypical depression; cardiovascular disease;
   depression course; metabolic syndrome; obesity; psychiatric
   comorbidities; socioeconomic disadvantage; unhealthy lifestyle
ID MAJOR DEPRESSION; BIPOLAR-II; FEATURES; SYMPTOMS; VALIDATION; SUBTYPES;
   OBESITY; EPIDEMIOLOGY; OUTPATIENTS; PREVALENCE
AB Background Depression is a heterogeneous disorder with multiple aetiological pathways and multiple therapeutic targets. This study aims to determine whether atypical depression (AD) characterized by reversed neurovegetative symptoms is associated with a more pernicious course and a different sociodemographic, lifestyle, and comorbidity profile than nonatypical depression (nonAD). Methods Among 157 366 adults who completed the UK Biobank Mental Health Questionnaire (MHQ), N = 37 434 (24%) met the DSM-5 criteria for probable lifetime major depressive disorder (MDD) based on the Composite International Diagnostic Interview Short Form. Participants reporting both hypersomnia and weight gain were classified as AD cases (N = 2305), and the others as nonAD cases (N = 35 129). Logistic regression analyses were conducted to examine differences between AD and nonAD in depression features, sociodemographic and lifestyle factors, lifetime adversities, psychiatric and physical comorbidities. Results Persons with AD experienced an earlier age of depression onset, longer, more severe and recurrent episodes, and higher help-seeking rates than nonAD persons. AD was associated with female gender, unhealthy behaviours (smoking, social isolation, low physical activity), more lifetime deprivation and adversity, higher rates of comorbid psychiatric disorders, obesity, cardiovascular disease (CVD), and metabolic syndrome. Sensitivity analyses comparing AD persons with those having typical neurovegetative symptoms (hyposomnia and weight loss) revealed similar results. Conclusions These findings highlight the clinical and public health significance of AD as a chronic form of depression, associated with high comorbidity and lifetime adversity. Our findings have implications for predicting depression course and comorbidities, guiding research on aetiological mechanisms, planning service use and informing therapeutic approaches.
C1 [Brailean, Anamaria; Davis, Katrina; Dregan, Alexandru; Hotopf, Matthew] Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Psychol Med, London, England.
   [Curtis, Jessica] Kings Coll London, Fac Life Sci & Med, London, England.
   [Davis, Katrina; Hotopf, Matthew] South London & Maudsley NHS Fdn Trust, London, England.
C3 University of London; King's College London; University of London;
   King's College London; South London & Maudsley NHS Trust
RP Brailean, A (corresponding author), Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Psychol Med, London, England.
EM anamaria@gmail.com
RI Hotopf, Matthew/E-4971-2010
OI Dregan, Alex/0000-0002-7620-4902; Hotopf, Matthew/0000-0002-3980-4466;
   Davis, Katrina/0000-0001-5945-4646
FU National Institute for Health Research (NIHR) Biomedical Research Centre
   at South London; Maudsley NHS Foundation Trust and King's College London
FX This paper represents independent research funded by the National
   Institute for Health Research (NIHR) Biomedical Research Centre at South
   London and Maudsley NHS Foundation Trust and King's College London. The
   views expressed are those of the authors and not necessarily those of
   the NHS, the NIHR or the Department of Health and Social Care.
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NR 49
TC 59
Z9 62
U1 2
U2 34
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0033-2917
EI 1469-8978
J9 PSYCHOL MED
JI Psychol. Med.
PD MAY
PY 2020
VL 50
IS 7
BP 1129
EP 1138
AR PII S0033291719001004
DI 10.1017/S0033291719001004
PG 10
WC Psychology, Clinical; Psychiatry; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA LR2FD
UT WOS:000535510400008
PM 31044683
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Benson, S
   Arck, PC
   Tan, S
   Mann, K
   Hahn, S
   Janssen, OE
   Schedlowski, M
   Elsenbruch, S
AF Benson, S.
   Arck, P. C.
   Tan, S.
   Mann, K.
   Hahn, S.
   Janssen, O. E.
   Schedlowski, M.
   Elsenbruch, S.
TI Effects of obesity on neuroendocrine, cardiovascular, and immune cell
   responses to acute psychosocial stress in premenopausal women
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE Obesity; Psychological stress; IL-6; Cortisol; Leukocytes; Immune system
ID CORONARY-HEART-DISEASE; POLYCYSTIC-OVARY-SYNDROME; PUBLIC SPEAKING
   STRESS; PITUITARY-ADRENAL AXIS; C-REACTIVE PROTEIN; INSULIN-RESISTANCE;
   METABOLIC SYNDROME; DIABETES-MELLITUS; BODY-MASS; INTERLEUKIN-6
AB Objective: To analyze the neuroendocrine and immune cell responses to acute psychosocial stress in obese compared to non-obese premenopausal women.
   Methods: N = 15 obese (BMI >= 30) and N = 24 (BMI < 30) non-obese premenopausal women underwent public speaking stress. State anxiety, ACTH, cortisol, and the redistribution of immune cells were measured before, during, and 10 and 45 min after public speaking. Serum hsCRP and serum IL-6 levels were analyzed before, and IL-6 additionally 45 min after stress.
   Results: In response to public speaking stress, both groups showed significant but comparable increases in state anxiety, plasma ACTH, and blood pressure (all p < 0.01; time effects). The cortisol stress response was significantly enhanced in obese women (p < 0.05; interaction effect). In addition, heart rate and diastolic blood pressure were significantly higher in obese women 10 min following stress (p < 0.05, t-tests). Public speaking stress led to a significant increase in IL-6 concentrations (p < 0.001; time effect), and obese women displayed higher IL-6 levels both pre- and post-stress (p < 0.05; group effect; between-group t-tests: pre-stress p < 0.05; post-stress p < 0.01). Baseline numbers of circulating leukocytes, granulocytes, CD3+ cells and hsCRP concentration were significantly higher in obese women (between-group t-tests: all p < 0.05, but the groups did not differ in the stress-induced redistribution of circulating leukocyte subpopulations.
   Conclusions: Our data reveal a strong association of obesity with chronic low-grade inflammation in premenopausal women. This pro-inflammatory state, together with altered neuroendocrine and cardiovascular stress responsiveness, may conceivably constitute one of the mechanisms linking psychological stress and the long-term health risks associated with obesity. (C) 2008 Elsevier Ltd. All rights reserved.
C1 [Benson, S.; Schedlowski, M.; Elsenbruch, S.] Univ Duisburg Essen, Univ Clin Essen, Dept Med Psychol & Behav Immunobiol, D-45122 Essen, Germany.
   [Arck, P. C.] Charite Univ Med Berlin, Ctr Internal Med & Dermatol, Clin Internal Med & Psychosomat, Berlin, Germany.
   [Tan, S.; Mann, K.] Univ Duisburg Essen, Univ Clin Essen, Dept Med, Div Endocrinol, D-45122 Essen, Germany.
   [Hahn, S.] Endokrinol Praxis, Wuppertal, Germany.
   [Janssen, O. E.] Ctr Endocrine & Metab Dis, Hamburg, Germany.
C3 University of Duisburg Essen; Berlin Institute of Health; Free
   University of Berlin; Humboldt University of Berlin; Charite
   Universitatsmedizin Berlin; University of Duisburg Essen
RP Elsenbruch, S (corresponding author), Univ Duisburg Essen, Univ Clin Essen, Dept Med Psychol & Behav Immunobiol, Hufelandstr 55, D-45122 Essen, Germany.
EM sigrid.eisenbruch@uk-essen.de
RI Tan, Susanne/GLN-3251-2022; Schedlowski, Manfred/GLU-7519-2022; Arck,
   Petra/D-7094-2013; Benson, Sven/I-1981-2014
OI Reger-Tan, Susanne/0000-0003-2692-8643; Elsenbruch,
   Sigrid/0000-0002-6528-2665; Benson, Sven/0000-0002-4487-4258; Arck,
   Petra Clara/0000-0002-2932-926X
FU Lienert-Stiftung
FX The authors would like to express their gratitude to Petra Busse, Evetin
   Hagen, Andrea Jaeger, and Natalie Riemenschneider for excellent
   technical support. Sven Benson was supported by a stipend from the
   Lienert-Stiftung.
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NR 47
TC 45
Z9 56
U1 0
U2 12
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD FEB
PY 2009
VL 34
IS 2
BP 181
EP 189
DI 10.1016/j.psyneuen.2008.08.019
PG 9
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA 408JM
UT WOS:000263431300003
PM 18838227
DA 2025-06-11
ER

PT J
AU Chandrasekaran, B
   Bairapareddy, KC
   Rao, CR
AF Chandrasekaran, Baskaran
   Bairapareddy, Kalyana Chakravarthy
   Rao, Chythra R.
TI Resistance Exercise Training on Musculoskeletal, Metabolic and
   Psychological Health in Sedentary Office Workers - Systematic Review and
   Meta-analysis
SO JOURNAL OF OCCUPATIONAL REHABILITATION
LA English
DT Review; Early Access
DE Strength training; Cardiometabolic risk; Pain; Office worker; Sedentary;
   Worker
ID PHYSICAL-ACTIVITY INTERVENTIONS; CHRONIC NECK PAIN; WORKPLACE;
   BEHAVIORS; TIME
AB Purpose To consolidate the emerging evidence on the effectiveness of resistance training (RT) in reducing the health risks among sedentary office workers. Methods Four electronic databases were searched for evidence from its inception till september 20, 2024. Studies were included if they examined any form of RT program targeting musculoskeletal, metabolic, or psychological health outcomes in office workers aged 18 years or older using PICOS criteria (Population - office workers, Intervention - RT program, Comparison - placebo or sham control and Outcomes - musculoskeletal, cardiometabolic and psychological health variables). Two reviewers independently screened the studies for risk of bias and assessed the certainty of the evidence. Results Out of 60 identified studies, 17 studies were eligible for narrative synthesis, and 16 were included in the meta-analysis. Modest reductions in neck (SMD = -1.76, I-2 = 88%, p < 0.00001) and shoulder discomfort (SMD = -13.29, I-2 = 91%, p < 0.00001), while marginal improvement in shoulder (SMD = 4.13, I-2 = 99%, p = 0.03) and neck extensor muscle strength (SMD = 9.07, I-2 = 9%, p < 0.00001). The cardiometabolic and mental health risk markers remain unaltered. High uncertainty of evidence was observed due to high heterogeneity, risk of bias, inconsistency and publication bias. Conclusion Limited evidence demonstrate supervised RT programs of any dose has a potential to improve muscular strength and discomfort while potential cardiometabolic and mental health risk outcomes remain unaltered. However, more high-quality research trials are needed to understand the effects of RT on health benefits.
C1 [Chandrasekaran, Baskaran] Manipal Acad Higher Educ, Manipal Coll Hlth Profess, Dept Exercise & Sports Sci, Manipal 576104, Karnataka, India.
   [Bairapareddy, Kalyana Chakravarthy] Univ Sharjah, Coll Hlth Sci, Dept Physiotherapy, Sharjah, U Arab Emirates.
   [Rao, Chythra R.] Manipal Acad Higher Educ, Kasturba Med Coll, Dept Community Med, Manipal 576104, Karnataka, India.
C3 Manipal Academy of Higher Education (MAHE); University of Sharjah;
   Manipal Academy of Higher Education (MAHE); Kasturba Medical College,
   Manipal
RP Chandrasekaran, B (corresponding author), Manipal Acad Higher Educ, Manipal Coll Hlth Profess, Dept Exercise & Sports Sci, Manipal 576104, Karnataka, India.
EM baskaran.c@manipal.edu; cdpraj@yahoo.com; chythra.raj@manipal.edu
RI Arumugam, Ashokan/ABA-4953-2022; Rao, Dr. Chythra R/D-5449-2016;
   Chandrasekaran, Baskaran/R-2824-2016
OI Arumugam, Ashokan/0000-0001-5795-3812; Rao, Dr. Chythra
   R/0000-0002-4016-2683; Chandrasekaran, Baskaran/0000-0003-1439-9158
FU Manipal Academy of Higher Education, Manipal; Health Sciences Library,
   Manipal Academy of Higher Education
FX Authors wish to thank the Health Sciences Library, Manipal Academy of
   Higher Education for the support for search strategy and trial search in
   four databases.
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NR 59
TC 0
Z9 0
U1 1
U2 1
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1053-0487
EI 1573-3688
J9 J OCCUP REHABIL
JI J. Occup. Rehabil.
PD 2025 FEB 14
PY 2025
DI 10.1007/s10926-025-10273-8
EA FEB 2025
PG 20
WC Rehabilitation; Social Issues
WE Social Science Citation Index (SSCI)
SC Rehabilitation; Social Issues
GA X0B9U
UT WOS:001422124100001
PM 39953203
OA hybrid
DA 2025-06-11
ER

PT J
AU Kim, HJ
   Kim, BS
   Kim, DW
   Shin, JH
AF Kim, Hyun-Jin
   Kim, Byung Sik
   Kim, Dong Wook
   Shin, Jeong-Hun
TI Estimated pulse wave velocity as a forefront indicator of developing
   metabolic syndrome in Korean adults
SO KOREAN JOURNAL OF INTERNAL MEDICINE
LA English
DT Article
DE Metabolic syndrome; Pulse wave analysis; Population; Arterial stiffness;
   Blood pressure
ID ARTERIAL STIFFNESS; OXIDATIVE STRESS; INFLAMMATION; HYPERTENSION;
   ASSOCIATION; MANAGEMENT; AGE
AB Background/Aims: The predictive value of the estimated pulse wave velocity (ePWV) for the development of metabolic syndrome has not yet been extensively explored. This study aimed to fill this gap by evaluating ePWV as a potential predictor of metabolic syndrome development in middle-aged Korean adults. Methods: Using prospective data obtained from the Ansan-Ansung cohort database, participants without metabolic syndrome at baseline were studied. ePWV was calculated using specific equations based on age and blood pressure. The primary outcome was the incidence of metabolic syndrome during a median follow-up period of 187 months. Results: Among the 6,186 participants, 2,726 (44.1%) developed metabolic syndrome during the follow-up period. ePWV values were categorized into tertiles to assess their predictive value for the development of metabolic syndrome. An ePWV cut-off of 7.407 m/s was identified as a predictor of metabolic syndrome development, with a sensitivity of 0.743 and a specificity of 0.464. Participants exceeding this cut-off, especially those in the third tertile (8.77-14.63 m/s), had a notably higher risk of developing metabolic syndrome. Specifically, the third tertile exhibited a 52.8% cumulative incidence compared with 30.8% in the first tertile. After adjustments, those in the third tertile faced a 1.530 -fold increased risk of metabolic syndrome (95% confidence interval, 1.330-1.761). Conclusions: ePWV is a significant predictor of the development of metabolic syndrome. This finding underscores the potential of ePWV as a cardiometabolic risk assessment tool and can thus provide useful information for primary prevention strategies.
C1 [Kim, Hyun-Jin; Kim, Byung Sik; Shin, Jeong-Hun] Hanyang Univ, Coll Med, Dept Internal Med, Div Cardiol,Guri Hosp, 153 Gyeongchun Ro, Guri 11923, South Korea.
   [Kim, Dong Wook] Harvard Med Sch, Brigham & Womens Hosp, Ctr Weight Management & Wellness, Div Endocrinol Diabet & Hypertens, Boston, MA USA.
   [Shin, Jeong-Hun] Hanyang Univ, Hanyang Univ Guri Hosp, Div Gastroenterol & Hepatol, Dept Internal Med,Coll Med, 153 Gyeongchun Ro, Guri 11923, South Korea.
C3 Hanyang University; Harvard University; Harvard University Medical
   Affiliates; Brigham & Women's Hospital; Harvard Medical School; Hanyang
   University
RP Shin, JH (corresponding author), Hanyang Univ, Coll Med, Dept Internal Med, Div Cardiol,Guri Hosp, 153 Gyeongchun Ro, Guri 11923, South Korea.; Shin, JH (corresponding author), Hanyang Univ, Hanyang Univ Guri Hosp, Div Gastroenterol & Hepatol, Dept Internal Med,Coll Med, 153 Gyeongchun Ro, Guri 11923, South Korea.
EM cardio.hyapex@gmail.com
RI Kim, Dahee/IAM-6955-2023; Kim, Hyun-Jin/AAJ-2905-2021; Shin,
   Jeong/O-1273-2019; Shin, Jeong Hun/T-3322-2017
OI Shin, Jeong Hun/0000-0002-6718-9763
FU Korean Society of Cardiometabolic Syndrome
FX The authors thank the Korean Society of Cardiometabolic Syndrome for
   providing funding for this online survey.
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NR 41
TC 0
Z9 0
U1 1
U2 4
PU KOREAN ASSOC INTERNAL MEDICINE
PI SEOUL
PA 101-2501 LOTTE CASTLE PRESIDENT, 109 MAPO-DAERO, MAPO-GU, SEOUL, SOUTH
   KOREA
SN 1226-3303
EI 2005-6648
J9 KOREAN J INTERN MED
JI Korean J. Intern. Med.
PD JUL
PY 2024
VL 39
IS 4
DI 10.3904/kjim.2024.015
EA JUN 2024
PG 17
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA YB0K3
UT WOS:001252898100001
PM 38910511
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Supriya, R
   Tam, BT
   Yu, AP
   Lee, PH
   Lai, CW
   Cheng, KK
   Yau, SY
   Chan, LW
   Yung, BY
   Sheridan, S
   Siu, PM
AF Supriya, Rashmi
   Tam, Bjorn T.
   Yu, Angus P.
   Lee, Paul H.
   Lai, Christopher W.
   Cheng, Kenneth K.
   Yau, Sonata Y.
   Chan, Lawrence W.
   Yung, Benjamin Y.
   Sheridan, Sinead
   Siu, Parco M.
TI Adipokines demonstrate the interacting influence of central obesity with
   other cardiometabolic risk factors of metabolic syndrome in Hong Kong
   Chinese adults
SO PLOS ONE
LA English
DT Article
ID NECROSIS-FACTOR-ALPHA; LOW HDL CHOLESTEROL; INSULIN-RESISTANCE;
   ADIPOSE-TISSUE; FOLLOW-UP; SYSTEMIC INFLAMMATION; NUCLEAR RECEPTORS;
   OXIDATIVE STRESS; BLOOD-PRESSURE; NORMAL-WEIGHT
AB Objective
   Metabolic syndrome (MetS) or prediabetes is a complex disorder that is defined by a clustering of cardiometabolic risk factors, including obesity, hypertriglyceridemia, reduced high-density lipoprotein (HDL) cholesterol, hypertension, and insulin resistance. Among cardiometabolic risk factors, central obesity plays a key role in the development of MetS through alterations in the secretion of adipokines and interacts with other MetS risk factors to unfavorably influence overall cardiometabolic risk. Obesity has grasped epidemic proportions in Asia, which has the highest number of people with diabetes in the world. But, the importance of central obesity in the clustering of all four MetS risk factors or vice versa in predicting severity of MetS has not yet been investigated in Asian population. Therefore, the present study examined the influence of central obesity on circulating levels of adipokines through its interaction with the clustering of cardiometabolic risk factors of MetS including hypergly-cemia, hypertriglyceridemia, dyslipidemia and hypertension in Hong Kong Chinese adults.
   Subjects
   Blood samples from 83 Hong Kong Chinese adults, who were previously screened for MetS according to the guideline of the United States National Cholesterol Education Program Expert Panel Adult Treatment Panel III criteria were selected. Insulin and adipokines, including visfatin, chemerin, plasminogen activator inhibitor-1 (PAI-1), resistin, C-C motif chemokine ligand 2 (CCL-2), interleukin-6 (IL-6), interleukin-8 (IL-8), interleukin-10 (IL-10), tumour necrosis factor-alpha (TNF-alpha), leptin and adiponectin were assessed.
   Results
   The interacting effect of central obesity with all of the other four MetS risk factors increased the proinflammatory status of adipokines (TNF-alpha, leptin) and decreased the anti-inflammatory status of adipokine (adiponectin).
   Conclusion
   Our results indicate that the inflammatory status of MetS may be more severe in the presence of central obesity. Adipokines, as biomarkers for pathophysiological changes, may help to improve early patient identification and to predict MetS-associated morbidity and mortality.
C1 [Supriya, Rashmi; Tam, Bjorn T.; Lai, Christopher W.; Cheng, Kenneth K.; Chan, Lawrence W.; Yung, Benjamin Y.] Hong Kong Polytech Univ, Fac Hlth & Social Sci, Dept Hlth Technol & Informat, Kowloon, Hong Kong, Peoples R China.
   [Yu, Angus P.; Sheridan, Sinead; Siu, Parco M.] Univ Hong Kong, Li Ka Shing Fac Med, Sch Publ Hlth, Pokfulam, Hong Kong, Peoples R China.
   [Lee, Paul H.] Hong Kong Polytech Univ, Fac Hlth & Social Sci, Sch Nursing, Kowloon, Hong Kong, Peoples R China.
   [Yau, Sonata Y.] Hong Kong Polytech Univ, Fac Hlth & Social Sci, Dept Rehabil Sci, Kowloon, Hong Kong, Peoples R China.
C3 Hong Kong Polytechnic University; University of Hong Kong; Hong Kong
   Polytechnic University; Hong Kong Polytechnic University
RP Siu, PM (corresponding author), Univ Hong Kong, Li Ka Shing Fac Med, Sch Publ Hlth, Pokfulam, Hong Kong, Peoples R China.
EM pmsiu@hku.hk
RI Lai, Christopher Wai Keung/A-3852-2014; Lee, Paul/F-2549-2010
OI Lai, Christopher Wai Keung/0000-0002-8010-7232; Yau, Sonata Suk
   Yu/0000-0002-7425-6741; Tam, Bjorn T./0000-0001-6740-8674; Supriya,
   Rashmi/0000-0003-2995-1910; Chan, Lawrence/0000-0001-6451-2273; Lee,
   Paul/0000-0002-5729-6450; Yu, Angus, Pak Hung/0000-0002-7684-6198
FU Hong Kong Research Grants Council Hong Kong Ph.D. Fellowship Scheme
   [RTVX PF13-11753]; Hong Kong Polytechnic University Research Fund
   (RTAS); Hong Kong Polytechnic University Research Fund [1-ZE17];
   University of Hong Kong Seed Fund for Basic Research; Hong Kong Research
   Grants Council General Research Fund [PolyU 5632/10M]
FX We declare all the funding or sources of support received during this
   specific study as the following, and all the funders had no role in
   study design, data collection and analysis, decision to publish, or
   preparation of the manuscript. This study was supported by the Hong Kong
   Research Grants Council Hong Kong Ph.D. Fellowship Scheme (RTVX
   PF13-11753), the Hong Kong Polytechnic University Research Fund (RTAS
   and 1-ZE17), The University of Hong Kong Seed Fund for Basic Research,
   and the Hong Kong Research Grants Council General Research Fund (PolyU
   5632/10M).
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NR 83
TC 27
Z9 29
U1 0
U2 2
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD AUG 16
PY 2018
VL 13
IS 8
AR e0201585
DI 10.1371/journal.pone.0201585
PG 20
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA GQ6RF
UT WOS:000441850400016
PM 30114249
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Ghosh, S
   Banerjee, KK
   Vaidya, VA
   Kolthur-Seetharam, U
AF Ghosh, S.
   Banerjee, K. K.
   Vaidya, V. A.
   Kolthur-Seetharam, U.
TI Early Stress History Alters Serum Insulin-Like Growth Factor-1 and
   Impairs Muscle Mitochondrial Function in Adult Male Rats
SO JOURNAL OF NEUROENDOCRINOLOGY
LA English
DT Article
DE maternal separation; mitochondria; muscle; IGF-1; metabolism
ID NEONATAL MATERNAL SEPARATION; TYPE-2 DIABETES-MELLITUS; EARLY-LIFE
   STRESS; METABOLIC SYNDROME; IGF-I; TRIGLYCERIDE CLEARANCE; PSYCHOLOGICAL
   STRESS; GENE-EXPRESSION; RISK-FACTOR; DEPRESSION
AB Early-life adversity is associated with an enhanced risk for adult psychopathology. Psychiatric disorders such as depression exhibit comorbidity for metabolic dysfunction, including obesity and diabetes. However, it is poorly understood whether, besides altering anxiety and depression-like behaviour, early stress also evokes dysregulation of metabolic pathways and enhances vulnerability for metabolic disorders. We used the rodent model of the early stress of maternal separation (ES) to examine the effects of early stress on serum metabolites, insulin-like growth factor (IGF)-1 signalling, and muscle mitochondrial content. Adult ES animals exhibited dyslipidaemia, decreased serum IGF1 levels, increased expression of liver IGF binding proteins, and a decline in the expression of specific metabolic genes in the liver and muscle, including Pck1, Lpl, Pdk4 and Hmox1. These changes occurred in the absence of alterations in body weight, food intake, glucose tolerance, insulin tolerance or insulin levels. ES animals also exhibited a decline in markers of muscle mitochondrial content, such as mitochondrial DNA levels and expression of TFAM (transcription factor A, mitochondrial). Furthermore, the expression of several genes involved in mitochondrial function, such as Ppargc1a, Nrf1, Tfam, Cat, Sesn3 and Ucp3, was reduced in skeletal muscle. Adult-onset chronic unpredictable stress resulted in overlapping and distinct consequences from ES, including increased circulating triglyceride levels, and a decline in the expression of specific metabolic genes in the liver and muscle, with no change in the expression of genes involved in muscle mitochondrial function. Taken together, our results indicate that a history of early adversity can evoke persistent changes in circulating IGF-1 and muscle mitochondrial function and content, which could serve to enhance predisposition for metabolic dysfunction in adulthood.
C1 [Ghosh, S.; Banerjee, K. K.; Vaidya, V. A.; Kolthur-Seetharam, U.] Tata Inst Fundamental Res, Dept Biol Sci, Homi Bhabha Rd, Bombay 400005, Maharashtra, India.
C3 Tata Institute of Fundamental Research (TIFR)
RP Kolthur-Seetharam, U (corresponding author), Tata Inst Fundamental Res, Dept Biol Sci, Homi Bhabha Rd, Bombay 400005, Maharashtra, India.
EM ullas@tifr.res.in
OI Ghosh, Shreya/0000-0003-2496-4528
FU TIFR
FX This study was supported by TIFR Intramural Funds to Dr Ullas
   Kolthur-Seetharam and Dr Vidita A. Vaidya.
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NR 49
TC 16
Z9 17
U1 1
U2 13
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0953-8194
EI 1365-2826
J9 J NEUROENDOCRINOL
JI J. Neuroendocrinol.
PD SEP
PY 2016
VL 28
IS 9
DI 10.1111/jne.12397
PG 14
WC Endocrinology & Metabolism; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology
GA EB0WF
UT WOS:000387066500001
PM 27196416
DA 2025-06-11
ER

PT J
AU Pinto, SL
   Juvanhol, LL
   de Oliveira, LL
   Clemente, RC
   Bressan, J
AF Pinto, Sonia Lopes
   Juvanhol, Leidjaira Lopes
   de Oliveira, Leandro Licursi
   Clemente, Rodolfo Castilho
   Bressan, Josefina
TI Changes in oxidative stress markers and cardiometabolic risk factors
   among Roux-en-Y gastric bypass patients after 3-and 12-months
   postsurgery follow-up
SO SURGERY FOR OBESITY AND RELATED DISEASES
LA English
DT Article
DE Oxidative stress; RYGB; Insulin resistance; TyG index; Nitric oxide
ID IDENTIFYING INSULIN-RESISTANCE; METABOLIC SYNDROME; SURROGATE; GLUCOSE;
   TRIGLYCERIDES; SENSITIVITY; CATALASE; INDEXES; OBESITY; ADULTS
AB Background: Evidence shows potential reduction in oxidative stress after Roux-en-Y gastric bypass. However, this outcome can vary, with postsurgery time, type of markers significantly altered, and possible relation with cardiometabolic risk markers, thus indicating the need for more studies.
   Objective: To evaluate changes in oxidative stress and its relation with cardiometabolic risk markers in Roux-en-Y gastric bypass patients after 3 and 12 months postsurgery.
   Setting: Federal University of Vicosa, Brazil.
   Methods: All data were collected before surgery and after 3 and 12 months postsurgery. Biochemical data were collected, and insulin resistance was determined by homeostasis model assessment of insulin resistance, triglyceride/glucose index, and triglycerides/high-density lipoprotein cholesterol. Additionally, catalase, superoxide dismutase, ferric-reducing antioxidant power, nitric oxide, carbonylated protein, and malondialdehyde were analyzed.
   Results: After 3 months postsurgery, excess weight loss was 46%. It increased to 82% after 12 months. We observed a significant reduction in levels of serum insulin, triglycerides, homeostasis model assessment of insulin resistance, triglyceride/glucose index, and triglycerides/high-density lipoprotein cholesterol indices and nitric oxide, throughout the entire study period. Also, reduced levels of total cholesterol, low-density lipoprotein, serum glucose, malondialdehyde, and superoxide dismutase were observed at 3 and 12 months postsurgery compared with baseline. On the other hand, reduction in ferric-reducing antioxidant power occurred only at 3 months postsurgery. We also observed that nitric oxide was positively correlated with triglycerides, percent excess weight loss, total cholesterol/high-density lipoprotein cholesterol, and triglyceride/glucose index.
   Conclusion: Roux-en-Y gastric bypass is able to reduce oxidative stress, insulin resistance, and improve lipid profile after 3 and 12 months postsurgery. Furthermore, changes in oxidative stress and cardiometabolic risk markers are correlated. (C) 2019 American Society for Bariatric Surgery. Published by Elsevier Inc. All rights reserved.
C1 [Pinto, Sonia Lopes; Clemente, Rodolfo Castilho] Fed Univ Tocantins, Nutr Course, Quadra 109 North,NS-15 Ave,ALCNO-14,Block Bala 2, BR-77001090 Palmas, Tocantins, Brazil.
   [Pinto, Sonia Lopes; Juvanhol, Leidjaira Lopes; Bressan, Josefina] Univ Fed Vicosa, Dept Nutr & Hlth, Vicosa, MG, Brazil.
   [de Oliveira, Leandro Licursi] Univ Fed Vicosa, Dept Gen Biol, Vicosa, MG, Brazil.
C3 Universidade Federal do Tocantins (UFT); Universidade Federal de Vicosa;
   Universidade Federal de Vicosa
RP Pinto, SL (corresponding author), Fed Univ Tocantins, Nutr Course, Quadra 109 North,NS-15 Ave,ALCNO-14,Block Bala 2, BR-77001090 Palmas, Tocantins, Brazil.
EM sonialopes@uft.edu.br
RI Bressan, Josefina/A-2598-2009; Juvanhol, Leidjaira/AAW-5793-2020;
   Licursi de Oliveira, Leandro/D-3616-2009
OI Licursi de Oliveira, Leandro/0000-0003-4353-7011; Lopes Juvanhol,
   Leidjaira/0000-0001-8012-6006; Bressan, Josefina/0000-0002-4993-9436
FU Coordination for the Improvement of Higher Education Personnel (CAPES)
   [190815/2014]
FX Supported by the Coordination for the Improvement of Higher Education
   Personnel (CAPES, project number 190815/2014).
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NR 32
TC 6
Z9 6
U1 0
U2 5
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1550-7289
EI 1878-7533
J9 SURG OBES RELAT DIS
JI Surg. Obes. Relat. Dis.
PD OCT
PY 2019
VL 15
IS 10
BP 1738
EP 1745
DI 10.1016/j.soard.2019.07.014
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA JN4WU
UT WOS:000496900500014
PM 31495634
DA 2025-06-11
ER

PT J
AU Swiatkiewicz, I
   Wozniak, A
   Taub, PR
AF Swiatkiewicz, Iwona
   Wozniak, Alina
   Taub, Pam R.
TI Time-Restricted Eating and Metabolic Syndrome: Current Status and Future
   Perspectives
SO NUTRIENTS
LA English
DT Review
DE time-restricted eating; metabolic syndrome; abdominal obesity;
   hyperglycemia; dyslipidemia; inflammation; oxidative stress;
   cardiometabolic risk; circadian rhythm; eating pattern
ID C-REACTIVE PROTEIN; CARDIOVASCULAR RISK-FACTORS; REDUCED MEAL FREQUENCY;
   CORONARY-HEART-DISEASE; CIRCADIAN-RHYTHMS; ENERGY-EXPENDITURE;
   NORMAL-WEIGHT; FOOD-INTAKE; CARDIOMETABOLIC HEALTH; CALORIC RESTRICTION
AB Metabolic syndrome (MetS) occurs in similar to 30% of adults and is associated with increased risk of cardiovascular disease and diabetes mellitus. MetS reflects the clustering of individual cardiometabolic risk factors including central obesity, elevated fasting plasma glucose, dyslipidemia, and elevated blood pressure. Erratic eating patterns such as eating over a prolonged period per day and irregular meal timing are common in patients with MetS. Misalignment between daily rhythms of food intake and circadian timing system can contribute to circadian rhythm disruption which results in abnormal metabolic regulation and adversely impacts cardiometabolic health. Novel approaches which aim at restoring robust circadian rhythms through modification of timing and duration of daily eating represent a promising strategy for patients with MetS. Restricting eating period during a day (time-restricted eating, TRE) can aid in mitigating circadian disruption and improving cardiometabolic outcomes. Previous pilot TRE study of patients with MetS showed the feasibility of TRE and improvements in body weight and fat, abdominal obesity, atherogenic lipids, and blood pressure, which were observed despite no overt attempt to change diet quantity and quality or physical activity. The present article aims at giving an overview of TRE human studies of individuals with MetS or its components, summarizing current clinical evidence for improving cardiometabolic health through TRE intervention in these populations, and presenting future perspectives for an implementation of TRE to treat and prevent MetS. Previous TRE trials laid the groundwork and indicate a need for further clinical research including large-scale controlled trials to determine TRE efficacy for reducing long-term cardiometabolic risk, providing tools for sustained lifestyle changes and, ultimately, improving overall health in individuals with MetS.
C1 [Swiatkiewicz, Iwona] Nicolaus Copernicus Univ, Coll Med, Dept Cardiol & Internal Med, PL-85094 Bydgoszcz, Poland.
   [Swiatkiewicz, Iwona; Taub, Pam R.] Univ Calif San Diego, Div Cardiovasc Med, La Jolla, CA 92037 USA.
   [Wozniak, Alina] Nicolaus Copernicus Univ, Coll Med, Dept Med Biol & Biochem, PL-85092 Bydgoszcz, Poland.
C3 Nicolaus Copernicus University; University of California System;
   University of California San Diego; Nicolaus Copernicus University
RP Swiatkiewicz, I (corresponding author), Nicolaus Copernicus Univ, Coll Med, Dept Cardiol & Internal Med, PL-85094 Bydgoszcz, Poland.; Swiatkiewicz, I (corresponding author), Univ Calif San Diego, Div Cardiovasc Med, La Jolla, CA 92037 USA.
EM iwona.swiatkiewicz@gmail.com; alina-wozniak@wp.pl; ptaub@health.ucsd.edu
RI Swiatkiewicz, Iwona/H-4279-2014; Wozniak, Alina/H-4699-2014
OI Taub, Pam/0000-0002-0684-0655; Wozniak, Alina/0000-0002-4492-4796
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NR 121
TC 71
Z9 76
U1 0
U2 35
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JAN
PY 2021
VL 13
IS 1
AR 221
DI 10.3390/nu13010221
PG 24
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA PW4IK
UT WOS:000610634600001
PM 33466692
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Jones, KT
   Shelton, RC
   Wan, J
   Li, L
AF Jones, Kristian T.
   Shelton, Richard C.
   Wan, Jun
   Li, Li
TI Impact of acute psychological stress on cardiovascular risk factors in
   face of insulin resistance
SO STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS
LA English
DT Article
DE Acute psychological stress; cardiovascular disease; risk factors;
   insulin resistance; cortisol; cytokines
ID METABOLIC SYNDROME; SENSITIVITY; RESPONSES; OBESITY; ATHEROSCLEROSIS;
   NEUROENDOCRINE; POLYMORPHISM; EXERCISE; DISEASE; ANGER
AB Individuals with insulin resistance (IR) are at greater risk for cardiovascular disease (CVD). Psychological stress may contribute to develop CVD in IR, although mechanisms are poorly understood. Our aim was to test the hypothesis that individuals with IR have enhanced emotional and physiological responses to acute psychological stress, leading to increased CVD risk. Sixty participants were enrolled into the study, and classified into IR group (n = 31) and insulin sensitive group (n = 29) according to the Quantitative insulin sensitivity check index, which was calculated based on an oral glucose tolerance test. The Trier social stress test, a standardized experimental stress paradigm, was performed on each participant, and emotional and physiological responses were examined. Blood was collected from each subject for insulin, cytokines, and cortisol measurements. Compared with the insulin-sensitive group, individuals with IR had significantly lower ratings of energy and calm, but higher fatigue levels in response to acute stressors. Individuals with IR also showed blunted heart rate reactivity following stress. In addition, the IR status was worsened by acute psychological stress as demonstrated by further increased insulin secretion. Furthermore, individuals with IR showed significantly increased levels of leptin and interleukin-6, but decreased levels of adiponectin, at baseline, stress test, and post-stress period. Our findings in individuals with IR under acute stress would allow a better understanding of the risks for developing CVD and to tailor the interventions for better outcomes.
C1 [Jones, Kristian T.] Meharry Med Coll, Nashville, TN 37208 USA.
   [Shelton, Richard C.; Li, Li] Univ Alabama Birmingham, Dept Psychiat & Behav Neurobiol, 1720 Univ Blvd, Birmingham, AL 35294 USA.
   [Wan, Jun] Wuhan Univ, Dept Cardiol, Renmin Hosp, Wuhan 430072, Peoples R China.
C3 Meharry Medical College; University of Alabama System; University of
   Alabama Birmingham; Wuhan University
RP Li, L (corresponding author), Univ Alabama Birmingham, Dept Psychiat & Behav Neurobiol, 1720 Univ Blvd, Birmingham, AL 35294 USA.
EM lili978@uab.edu
RI Li, Li/M-3237-2016; Shelton, Richard/AAC-4137-2022
FU Brain and Behavior Research Foundation [21623]; National Institute of
   Diabetes And Digestive And Kidney Diseases [P30DK056336, P30DK079626];
   University of Alabama at Birmingham
FX This work was supported by a Young Investigator Award from the Brain and
   Behavior Research Foundation [21623] to L. L. and Awards [P30DK056336,
   P30DK079626], from the National Institute of Diabetes And Digestive And
   Kidney Diseases to Nutrition Obesity Research Center and Diabetes
   Research Center, respectively, at the University of Alabama at
   Birmingham.
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NR 39
TC 9
Z9 13
U1 0
U2 6
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1025-3890
EI 1607-8888
J9 STRESS
JI Stress
PY 2016
VL 19
IS 6
BP 585
EP 592
DI 10.1080/10253890.2016.1231804
PG 8
WC Behavioral Sciences; Endocrinology & Metabolism; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Behavioral Sciences; Endocrinology & Metabolism; Neurosciences &
   Neurology
GA EJ4RW
UT WOS:000393205500005
PM 27588343
OA Green Accepted, Green Submitted
DA 2025-06-11
ER

PT J
AU Williams, KL
   Ruekert, L
   Lum, C
AF Williams, Kristal L.
   Ruekert, Laura
   Lum, Cheen
TI Treatment of bipolar disorder: A focus on medication therapy for mania
SO FORMULARY
LA English
DT Article
ID LONG-TERM TREATMENT; I DISORDER; DOUBLE-BLIND; MAINTENANCE TREATMENT;
   ARIPIPRAZOLE MONOTHERAPY; OPEN-LABEL; ADD-ON; LITHIUM; OLANZAPINE; TRIAL
AB Bipolar disorder (BPD) is a recurrent psychiatric disorder characterized by episodes of mania and hypomania, depression, or mixed episodes. Individuals with BPD often experience anxiety and decreased cognitive performance and productivity. BPD has emerged as a major health concern, with lifelong social and occupational impairment and poor prognosis secondary to its substantially elevated morbidity and mortality rates, which are largely due to associated cardiovascular disease, metabolic syndrome, substance abuse or misuse, and potential for physical self-harm. The lifetime prevalence of bipolar spectrum disorders is approximately 3% to 7% of the population. Given the disease complexity, individuals with BPD often require lifelong pharmacological therapy to achieve desired treatment outcomes. In recent years there has been an explosion of new investigations into the pathophysiology of BPD and its medication therapies. This article will review current, emerging, and controversial therapies for the treatment of BPD, specifically the mania aspect. (Formulary. 2011;46:82-97.)
C1 [Williams, Kristal L.; Ruekert, Laura] Butler Univ, Coll Pharm & Hlth Sci, Indianapolis, IN 46208 USA.
   [Williams, Kristal L.] Indiana Univ Hlth, Indianapolis, IN USA.
   [Ruekert, Laura; Lum, Cheen] Community Hosp N, Indianapolis, IN USA.
C3 Butler University; Indiana University Health; IU Health University
   Hospital
RP Williams, KL (corresponding author), Butler Univ, Coll Pharm & Hlth Sci, Indianapolis, IN 46208 USA.
RI Williams, Kenneth/O-5181-2014; Ruekert, Laura/T-2126-2019
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NR 52
TC 0
Z9 0
U1 0
U2 7
PU ADVANSTAR COMMUNICATIONS INC
PI DULUTH
PA 131 W 1ST STREET, DULUTH, MN 55802 USA
SN 1082-801X
EI 1938-1166
J9 FORMULARY
JI Formulary
PD MAR
PY 2011
VL 46
IS 3
BP 82
EP +
PG 13
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 741AT
UT WOS:000288836200002
DA 2025-06-11
ER

PT J
AU Simáo, ANC
   Lozovoy, MAB
   Dichi, I
AF Colado Simao, Andrea Name
   Batisti Lozovoy, Marcell Alysson
   Dichi, Isaias
TI The uric acid metabolism pathway as a therapeutic target in
   hyperuricemia related to metabolic syndrome
SO EXPERT OPINION ON THERAPEUTIC TARGETS
LA English
DT Review
DE inflammation; insulin resistance; metabolic syndrome; oxidative stress;
   uric acid
ID IMPROVES ENDOTHELIAL FUNCTION; INSULIN-RESISTANCE SYNDROME; SHORT-TERM
   TREATMENT; C-REACTIVE PROTEIN; RISK-FACTOR; CARDIOVASCULAR RISK;
   BLOOD-PRESSURE; PLASMA-CONCENTRATIONS; ANTIOXIDANT CAPACITY; OXIDATIVE
   STRESS
AB Introduction: Uric acid (UA) increase is considered an important risk factor for the development of cardiovascular disease (CVD) favoring oxidative stress and endothelial dysfunction and is also involved in metabolic syndrome (MS) pathophysiology.
   Areas covered: Insulin has a physiological action on renal tubules, causing a reduction in UA clearance, what could explain the hyperuricemia found in MS. On the other hand, it was also hypothesized a causal role of UA in fructose-induced MS. Moreover, it has been suggested that higher UA levels predict the development of MS. MS subjects present a redox imbalance and UA participates in this process. UA can contribute to oxidative stress present in MS; however, it has also an important role in the antioxidant defense system. Although UA may have a protective effect due to its antioxidant properties, it is clear that the dominant effect of UA in MS is deleterious. All-cause mortality and CVD have been shown to be increased with higher UA levels.
   Expert opinion: It is extremely important to prescribe drugs which concomitantly decrease hyperuricemia and improve co-morbidities associated with hyperuricemia. Long-term studies to verify the consequences of decreasing UA concentration below current recommendations in asymptomatic patients are needed.
C1 [Dichi, Isaias] Univ Londrina, Dept Internal Med, BR-86038440 Londrina, Parana, Brazil.
   [Colado Simao, Andrea Name] Univ Londrina, Dept Pathol Clin Anal & Toxicol, BR-86038440 Londrina, Parana, Brazil.
   [Batisti Lozovoy, Marcell Alysson] Univ N Parana UNOPAR, Dept Clin Anal, BR-86041120 Londrina, Parana, Brazil.
C3 University Norte Parana
RP Dichi, I (corresponding author), Univ Londrina, Dept Internal Med, Rua Robert Koch 60 Bairro Cervejaria, BR-86038440 Londrina, Parana, Brazil.
EM dichi@sercomtel.com.br
RI Lozovoy, Marcell/AAM-4897-2021; Simão, Andrea/AAM-4892-2021
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NR 103
TC 32
Z9 36
U1 1
U2 26
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1472-8222
EI 1744-7631
J9 EXPERT OPIN THER TAR
JI Expert Opin. Ther. Targets
PD DEC
PY 2012
VL 16
IS 12
BP 1175
EP 1187
DI 10.1517/14728222.2012.723694
PG 13
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 039HM
UT WOS:000311235400004
PM 23020656
DA 2025-06-11
ER

PT J
AU Jones, EJ
   Feinberg, ME
   Graham-Engeland, JE
   Jones, DE
   Schreier, HMC
AF Jones, Emily J.
   Feinberg, Mark E.
   Graham-Engeland, Jennifer E.
   Jones, Damon E.
   Schreier, Hannah M. C.
TI A perinatal coparenting intervention: Effects of a randomized trial on
   parent cardiometabolic risk and self-reported health
SO BIOLOGICAL PSYCHOLOGY
LA English
DT Article
DE Coparenting; Intervention; Cholesterol; Self-rated health; Inflammation
ID C-REACTIVE PROTEIN; DRIED BLOOD SPOTS; CARDIOVASCULAR-DISEASE; RATED
   HEALTH; SYSTEMIC INFLAMMATION; POSTPARTUM DEPRESSION; FAMILY
   FOUNDATIONS; METABOLIC SYNDROME; MARITAL CONFLICT; AFRICAN-AMERICAN
AB Background: The transition to parenthood is a common yet stressful experience faced by many young and midlife adults, and the risk of cardiometabolic conditions also begins to rise at this time. Consequently, parenthood represents an opportune time to intervene with adults to support their psychological and physical health.
   Purpose: We examined whether the benefits of the Family Foundations program, a perinatal preventative intervention promoting positive coparenting, extend beyond documented mental health and family relationship outcomes to better cardiometabolic risk factors among parents.
   Methods: We analyzed data from 183 couples (n = 366 participants) who, eight years prior, were randomly assigned to the 9-session perinatal preventative intervention program or a control condition. We collected dried blood spots to measure C-reactive protein (CRP), interleukin-6 (IL-6), and cholesterol; parents also reported on their self-rated health.
   Results: Randomization to the intervention condition was associated with lower cholesterol (B=-.081, p =.049). Among parents who demonstrated more negative communication styles at pretest (during pregnancy), the intervention was further associated with better self-rated health (B=.181, p =.018). Participation in the intervention program was also marginally associated with lower CRP (B=-.261, p =.077), particularly among mothers (B=-.428, p =.076).
   Conclusions: These findings indicate that coparenting-focused interventions, such as Family Foundations, can lead to benefits beyond psychosocial and behavioral outcomes, and suggest that Family Foundations may improve parents' longer-term physical health, with potentially more benefits among couples who demonstrated more negative communication styles during pregnancy.
C1 [Jones, Emily J.] Univ Pittsburgh, Dept Psychiat, Pittsburgh, PA 15213 USA.
   [Feinberg, Mark E.] Penn State Univ, Edna Bennett Pierce Prevent Res Ctr, University Pk, PA 16802 USA.
   [Graham-Engeland, Jennifer E.; Schreier, Hannah M. C.] Penn State Univ, Dept Biobehav Hlth, University Pk, PA 16802 USA.
   [Schreier, Hannah M. C.] 219 Biobehav Hlth Bldg, University Pk, PA 16802 USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE); University
   of Pittsburgh; Pennsylvania Commonwealth System of Higher Education
   (PCSHE); Pennsylvania State University; Pennsylvania State University -
   University Park; Penn State Behrend; Pennsylvania Commonwealth System of
   Higher Education (PCSHE); Pennsylvania State University; Pennsylvania
   State University - University Park; Penn State Behrend
RP Schreier, HMC (corresponding author), 219 Biobehav Hlth Bldg, University Pk, PA 16802 USA.
EM hannah.schreier@psu.edu
FU National Heart, Lung, and Blood Institute [R01 HL137809]; Eunice Kennedy
   Shriver National Institute of Child Health & Human Development [R01
   HD058529, R01 HD084476]
FX Research reported in this manuscript was supported by funding from the
   National Heart, Lung, and Blood Institute (R01 HL137809 (Schreier)) and
   Eunice Kennedy Shriver National Institute of Child Health & Human
   Development (R01s HD058529 and HD084476 (Feinberg)).
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NR 72
TC 1
Z9 1
U1 1
U2 7
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0301-0511
EI 1873-6246
J9 BIOL PSYCHOL
JI Biol. Psychol.
PD OCT
PY 2023
VL 183
AR 108664
DI 10.1016/j.biopsycho.2023.108664
EA AUG 2023
PG 10
WC Psychology, Biological; Behavioral Sciences; Psychology; Psychology,
   Experimental
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Behavioral Sciences
GA S2VL8
UT WOS:001069798700001
PM 37625684
OA Bronze, Green Accepted
DA 2025-06-11
ER

PT J
AU Nicolson, GL
AF Nicolson, Garth L.
TI Metabolic syndrome and mitochondrial function: Molecular replacement and
   antioxidant supplements to prevent membrane peroxidation and restore
   mitochondrial function
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Review
DE lipids; antioxidants; diabetes; atherosclerosis; vascular inflammation;
   heart disease; renal disease; liver disease; dietary supplement;
   mitochondria; fatigue
ID C-REACTIVE PROTEIN; 3RD NATIONAL-HEALTH; ENDOTHELIUM-DEPENDENT
   VASODILATION; INSULIN-RESISTANCE SYNDROME; TYPE-2 DIABETES-MELLITUS;
   FATTY-ACID TRANSPORT; OXIDATIVE STRESS; CHRONIC-FATIGUE;
   SKELETAL-MUSCLE; NITRIC-OXIDE
AB Metabolic syndrome consists of a cluster of metabolic conditions, such as hypertriglyeridemia, hyperlow-density lipoproteins, hypo-high-density lipoproteins, insulin resistance, abnormal glucose tolerance and hypertension, that-in combination with genetic susceptibility and abdominal obesity-are risk factors for type 2 diabetes, vascular inflammation, atherosclerosis, and renal, liver and heart disease. One of the defects in metabolic syndrome and its associated diseases is excess cellular oxidative stress (mediated by reactive oxygen and nitrogen species, ROS/RNS) and oxidative damage to mitochondrial components, resulting in reduced efficiency of the electron transport chain. Recent evidence indicates that reduced mitochondrial function caused by ROS/RNS membrane oxidation is related to fatigue, a common complaint of MS patients. Lipid replacement therapy (LRT) administered as a nutritional supplement with antioxidants can prevent excess oxidative membrane damage, restore mitochondrial and other cellular membrane functions and reduce fatigue. Recent clinical trials have shown the benefit of LRT plus antioxidants in restoring mitochondrial electron transport function and reducing moderate to severe chronic fatigue. Thus LRT plus antioxidant supplements should be considered for metabolic syndrome patients who suffer to various degrees from fatigue. J. Cell. Biochem. 100: 1352-1369, 2007. (c) 2007 Wiley-Liss, Inc.
C1 Inst Mol Med, Off President, Dept Mol Pathol, Huntington Beach, CA 92647 USA.
RP Nicolson, GL (corresponding author), Inst Mol Med, Off President, Dept Mol Pathol, 16371 Gothard St H, Huntington Beach, CA 92647 USA.
EM gnicolson@immed.org
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NR 170
TC 76
Z9 103
U1 0
U2 15
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0730-2312
EI 1097-4644
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PD APR 15
PY 2007
VL 100
IS 6
BP 1352
EP 1369
DI 10.1002/jcb.21247
PG 18
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA 152ZF
UT WOS:000245400300003
PM 17243117
DA 2025-06-11
ER

PT J
AU Nysather, J
   Kaya, E
   Manka, P
   Gudsoorkar, P
   Syn, WK
AF Nysather, Jacob
   Kaya, Eda
   Manka, Paul
   Gudsoorkar, Prakash
   Syn, Wing-Kin
TI Nonalcoholic Fatty Liver Disease and Chronic Kidney Disease Cross Talk
SO ADVANCES IN KIDNEY DISEASE AND HEALTH
LA English
DT Article
DE Nonalcoholic fatty liver disease (NAFLD); Nonalcoholic steatohepatitis
   (NASH); Chronic kidney disease (CKD); Meta-bolic syndrome
ID ENDOPLASMIC-RETICULUM STRESS; FETUIN-A; INSULIN-RESISTANCE; METABOLIC
   SYNDROME; GUT MICROBIOTA; RISK-FACTORS; WEIGHT-LOSS;
   HEPATOCELLULAR-CARCINOMA; ENDOTHELIAL DYSFUNCTION; AMERICAN ASSOCIATION
AB Nonalcoholic fatty liver disease is a multisystem condition with effects beyond the liver. The identification of chronic kidney disease as an independent mediator of nonalcoholic fatty liver disease or associated entity with shared cardiometabolic risk factors remains controversial and continues to draw scientific interest. With increasing prevalence of nonalcoholic fatty liver disease and lack of Food and Drug Administration approved therapies, these shared cardiometabolic risk factors have drawn significant attention. In this article, we review shared pathophysiological mechanisms between nonalcoholic fatty liver disease and chronic kidney disease along with current treatment strategies that might be useful for both disease processes.& COPY; 2023 by the National Kidney Foundation, Inc. All rights reserved.
C1 [Nysather, Jacob; Gudsoorkar, Prakash] Univ Cincinnati, Div Nephrol, Cincinnati, OH USA.
   [Nysather, Jacob; Gudsoorkar, Prakash] Univ Cincinnati, Kidney CARE Program, Cincinnati, OH USA.
   [Kaya, Eda; Manka, Paul] Ruhr Univ Bochum, Univ Hosp Knappschaftskrankenhaus Bochum, Dept Internal Med, Bochum, Germany.
   [Syn, Wing-Kin] St Louis Univ, Sch Med, Div Gastroenterol & Hepatol, St Louis, MO USA.
   [Syn, Wing-Kin] Med Univ South Carolina, Div Gastroenterol & Hepatol, Charleston, SC USA.
   [Syn, Wing-Kin] Univ Basque Country, Euskal Herriko Unibertsitatea Univ Pais Vasco, Fac Med & Nursing, Dept Physiol, Leioa, Spain.
C3 University System of Ohio; University of Cincinnati; University System
   of Ohio; University of Cincinnati; Ruhr University Bochum; Saint Louis
   University; Medical University of South Carolina; University of Basque
   Country
RP Syn, WK (corresponding author), St Louis Univ, Sch Med, Liver Ctr, Gastroenterol & Hepatol, St Louis, MO 63104 USA.; Syn, WK (corresponding author), Med Univ South Carolina, Charleston, SC 29425 USA.
EM wingkin.syn@health.slu.edu
RI Syn, Wing-Kin/AAB-8406-2020; Manka, Paul/ABH-2421-2020; Kaya,
   Eda/AAN-9567-2020
OI Manka, Paul/0000-0001-8589-7280; Nysather, Jacob/0000-0003-1687-1129;
   Gudsoorkar, Prakash/0000-0001-9044-6054; Kaya, Eda/0000-0002-9293-2811
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NR 183
TC 4
Z9 4
U1 1
U2 7
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 2949-8147
EI 2949-8139
J9 ADV KIDNEY DIS HEAL
JI Adv. Kidney Dis. Heal.
PD JUL
PY 2023
VL 30
IS 4
BP 315
EP 335
DI 10.1053/j.akdh.2023.04.001
EA AUG 2023
PG 21
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA S2WD5
UT WOS:001069816500001
PM 37657879
DA 2025-06-11
ER

PT J
AU Sen, ZD
   Danyeli, LV
   Woelfer, M
   Lamers, F
   Wagner, G
   Sobanski, T
   Walter, M
AF Sen, Zumrut Duygu
   Danyeli, Lena Vera
   Woelfer, Marie
   Lamers, Femke
   Wagner, Gerd
   Sobanski, Thomas
   Walter, Martin
TI Linking atypical depression and insulin resistance-related disorders via
   low-grade chronic inflammation: Integrating the phenotypic, molecular
   and neuroanatomical dimensions
SO BRAIN BEHAVIOR AND IMMUNITY
LA English
DT Review
DE Inflammation; Major depressive disorder; Atypical depression; Type 2
   diabetes mellitus; Obesity; Metabolic syndrome; Insulin resistance;
   Stress; Anterior cingulate cortex
ID HIGH-FAT DIET; C-REACTIVE PROTEIN; NECROSIS-FACTOR-ALPHA; CEREBRAL
   GLUCOSE-METABOLISM; ANTERIOR CINGULATE CORTEX; MAJOR DEPRESSION;
   TNF-ALPHA; FUNCTIONAL CONNECTIVITY; CORTICAL THICKNESS; PREFRONTAL
   CORTEX
AB Insulin resistance (IR) and related disorders, such as T2DM, increase the risk of major depressive disorder (MDD) and vice versa. Current evidence indicates that psychological stress and overeating can induce chronic low-grade inflammation that can interfere with glutamate metabolism in MDD as well as insulin signaling, particularly in the atypical subtype. Here we first review the interactive role of inflammatory processes in the development of MDD, IR and related metabolic disorders. Next, we describe the role of the anterior cingulate cortex in the pathophysiology of MDD and IR-related disorders. Furthermore, we outline how specific clinical features of atypical depression, such as hyperphagia, are more associated with inflammation and IR-related disorders. Finally, we examine the regional specificity of the effects of inflammation on the brain that show an overlap with the functional and morphometric brain patterns activated in MDD and IR-related disorders.
C1 [Sen, Zumrut Duygu; Walter, Martin] Univ Tubingen, Dept Psychiat & Psychotherapy, Calwerstr 14, D-72076 Tubingen, Germany.
   [Sen, Zumrut Duygu; Danyeli, Lena Vera; Wagner, Gerd; Walter, Martin] Jena Univ Hosp, Dept Psychiat & Psychotherapy, Philosophenweg 3, D-07743 Jena, Germany.
   [Danyeli, Lena Vera; Woelfer, Marie; Walter, Martin] Clin Affect Neuroimaging Lab CANLAB, Leipziger Str 44,Bldg 65, D-39120 Magdeburg, Germany.
   [Danyeli, Lena Vera; Woelfer, Marie; Walter, Martin] Leibniz Inst Neurobiol, Brenneckestr 6, D-39118 Magdeburg, Germany.
   [Lamers, Femke] Vrije Univ, Amsterdam UMC, Dept Psychiat, Oldenaller 1, NL-1081 HJ Amsterdam, Netherlands.
   [Sobanski, Thomas] Thueringen Kliniken Georgius Agr GmbH, Dept Psychiat Psychotherapy & Psychosomat Med, Rainweg 68, D-07318 Saalfeld, Germany.
C3 Eberhard Karls University of Tubingen; Friedrich Schiller University of
   Jena; Leibniz Association; Leibniz Institut fur Neurobiologie (LIN);
   Vrije Universiteit Amsterdam; University of Amsterdam
RP Walter, M (corresponding author), Jena Univ Hosp, Dept Psychiat & Psychotherapy, Philosophenweg 3, D-07743 Jena, Germany.
EM martin.walter@med.uni-jena.de
RI Lamers, Femke/G-5161-2012; Wagner, Gerd/F-2990-2010
OI Woelfer, Marie/0000-0001-7128-4678
FU German Research Foundation (Deutsche Forschungsgemeinschaft, DFG)
   [SFB779-A06]; EU; Netherlands Organisation for Health Research and
   Development (ZonMw) [636310017]; Medical Faculty of the
   Otto-von-Guericke University Magdeburg; German Academic Exchange Service
   (DAAD)
FX This work was supported by the German Research Foundation (Deutsche
   Forschungsgemeinschaft, DFG, SFB779-A06 given to Prof. M. Walter) and
   through the EU-funded Horizon 2020 project "FAT4BBRAIN". Dr. Lamers
   currently receives funding from the Netherlands Organisation for Health
   Research and Development (ZonMw, project nr 636310017). M. Woelfer was
   supported by scholarship from the Medical Faculty of the
   Otto-von-Guericke University Magdeburg and received a scholarship from
   the German Academic Exchange Service (DAAD).
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NR 302
TC 32
Z9 35
U1 3
U2 20
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0889-1591
EI 1090-2139
J9 BRAIN BEHAV IMMUN
JI Brain Behav. Immun.
PD MAR
PY 2021
VL 93
BP 335
EP 352
DI 10.1016/j.bbi.2020.12.020
EA MAR 2021
PG 18
WC Immunology; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Immunology; Neurosciences & Neurology; Psychiatry
GA RB3SE
UT WOS:000632033800007
PM 33359233
OA Green Published
DA 2025-06-11
ER

PT J
AU Lin, ZQ
   Lawrence, WR
   Huang, YH
   Lin, QX
   Gao, YH
AF Lin, Ziqiang
   Lawrence, Wayne R.
   Huang, Yanhong
   Lin, Qiaoxuan
   Gao, Yanhui
TI Classifying depression using blood biomarkers: A large population study
SO JOURNAL OF PSYCHIATRIC RESEARCH
LA English
DT Article
DE Depression; Machine learning; Random forest; Obesity; Diabetes;
   Metabolic syndrome
ID DISSEMINATED INTRAVASCULAR COAGULATION; CELL DISTRIBUTION WIDTH; FATTY
   LIVER-DISEASE; METABOLIC SYNDROME; INCOME INEQUALITY; MAJOR DEPRESSION;
   MENTAL-HEALTH; ASSOCIATION; BILIRUBIN; BASOPHILS
AB Background: Depression is a common mood disorder characterized by persistent low mood or lack of interest in activities. People with other chronic medical conditions such as obesity and diabetes are at greater risk of depression. Diagnosing depression can be a challenge for primary care providers and others who lack specialized training for these disorders and have insufficient time for in-depth clinical evaluation. We aimed to create a more objective low-cost diagnostic tool based on patients' characteristics and blood biomarkers. Methods: Blood biomarker results were obtained from the National Health and Nutrition Examination Survey (NHANES, 2007-2016). A prediction model utilizing random forest (RF) in NHANES (2007-2014) to identify depression was derived and validated internally using out-of-bag technique. Afterwards, the model was validated externally using a validation dataset (NHANES, 2015-2016). We performed four subgroup comparisons (full dataset, overweight and obesity dataset (BMI >= 25), diabetes dataset, and metabolic syndrome dataset) then selected features using backward feature selection from RF. Results: Family income, Gamma-glutamyl transferase (GGT), glucose, Triglyceride, red cell distribution width (RDW), creatinine, Basophils count or percent, Eosinophils count or percent, and Bilirubin were the most important features from four models. In the training set, AUC from full, overweight and obesity, diabetes, and metabolic syndrome datasets were 0.83, 0.80, 0.82, and 0.82, respectively. In the validation set, AUC were 0.69, 0.63, 0.66, and 0.64, respectively. Conclusion: Results of routine blood laboratory tests had good predictive value for distinguishing depression cases from control groups not only in the general population, but also individuals with metabolism-related chronic diseases.
C1 [Lin, Ziqiang; Gao, Yanhui] Jinan Univ, Sch Basic Med & Publ Hlth, Dept Prevent Med, Guangzhou 510632, Peoples R China.
   [Lin, Ziqiang] New York Univ Sch Med, Dept Psychiat, 1 Pk Ave, New York, NY 10016 USA.
   [Lin, Ziqiang] SUNY Albany, Dept Math & Stat, Coll Arts & Sci, 1400 Washington Ave, Albany, NY 12222 USA.
   [Lawrence, Wayne R.] SUNY Albany, Sch Publ Hlth, Dept Epidemiol & Biostat, 1 Univ Pl, Rensselaer, NY 12144 USA.
   [Huang, Yanhong] Guangdong Pharmaceut Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Guangzhou 510310, Peoples R China.
   [Lin, Qiaoxuan] Guangzhou Hlth Technol Identificat & Human Resour, Dept Stat, Guangzhou 510000, Guangdong, Peoples R China.
C3 Jinan University; New York University; State University of New York
   (SUNY) System; University at Albany, SUNY; State University of New York
   (SUNY) System; University at Albany, SUNY; Guangdong Pharmaceutical
   University
RP Gao, YH (corresponding author), Jinan Univ, Sch Basic Med & Publ Hlth, Dept Prevent Med, Guangzhou 510632, Peoples R China.
EM gao_yanhui@163.com
RI Lin, Qiaoxuan/AAC-1202-2022; Lawrence, Wayne/N-3626-2016
OI Lin, Ziqiang/0000-0003-1990-6788
FU National Social Science Foundation, China (2019 key project of education
   sciences) [ALA190015]
FX This Study was supported by supported by National Social Science
   Foundation, China (2019 key project of education sciences, grant number
   ALA190015) .
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NR 77
TC 15
Z9 17
U1 5
U2 26
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-3956
EI 1879-1379
J9 J PSYCHIATR RES
JI J. Psychiatr. Res.
PD AUG
PY 2021
VL 140
BP 364
EP 372
DI 10.1016/j.jpsychires.2021.05.070
EA JUN 2021
PG 9
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA TQ5OX
UT WOS:000678330600016
PM 34144440
DA 2025-06-11
ER

PT J
AU Grozdan, AM
   Ghiuru, R
   Duceac, LD
   Bodescu, MM
AF Grozdan, Ana Minodora
   Ghiuru, Rodica
   Duceac, Letitia Doina
   Bodescu, Maria Madalina
TI The Prevention of the Risk of Depression at Metabolic Syndrome Patients
   by Making a Minimum Hepatic Investigation
SO REVISTA DE CHIMIE
LA English
DT Article
DE depresion; risk factors; alcohol use; metabolic syndrome; hepatic
   steatosis
AB Depression is a mental disorder characterized by a deep change state of the thymus, disposition, in the sense of sadness, suffering and moral inhibition psychomotor generally associating with psychoactive substance dependence. An association in particular alcoholism and other psychiatric disorders was noticed more decades. Obesity many of the SML may determine, outside taps organ important psychological imbalances, linked both to aesthetics. If the connection between S M and cardiovascular disease has been studied in detail, the correlation between S M and the emergence of depressive episodes prospects remains an NIS. The aim of the study was to determine a minimum package Biochemical investigations of liver function in patients with MS need notice for preventing risk of depression, the study objective was to demonstrate the involvement consumption both alcohol and depressive episodes in the development of steatosis hepatic. Consuming Alcohol was shown to be the central element both in depression and Development Department hepatic steatosis, MS patients have increased risk of developing hepatic steatosis by lipid metabolic changes involve them this nosological entity. Additional alcohol is a factor that can increase the risk of steatosis and depression.
C1 [Grozdan, Ana Minodora; Ghiuru, Rodica; Duceac, Letitia Doina] Apollonia Univ Iasi, 2 Muzicii Str, Iasi 700399, Romania.
   [Bodescu, Maria Madalina] Gr T Popa Univ Med & Pharm, 16 Univ Str, Iasi 700115, Romania.
   [Ghiuru, Rodica] Clin Hosp CF Iasi, Iasi, Romania.
   [Duceac, Letitia Doina] Children Emergency Hosp St Mary Iasi, Iasi, Romania.
C3 Apollonia University; Grigore T Popa University of Medicine & Pharmacy
RP Duceac, LD (corresponding author), Apollonia Univ Iasi, 2 Muzicii Str, Iasi 700399, Romania.; Duceac, LD (corresponding author), Children Emergency Hosp St Mary Iasi, Iasi, Romania.
EM letimedr@yahoo.com
RI Duceac, Letitia/HPD-9900-2023
OI Duceac, Letita Doina/0000-0001-6868-8014
CR APETREI E., 2009, REV ROMANA CARDIOLOG, VXIV, P165
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NR 10
TC 2
Z9 2
U1 0
U2 5
PU CHIMINFORM DATA S A
PI BUCHAREST
PA CALEA PLEVNEI NR 139, SECTOR 6, BUCHAREST R-77131, ROMANIA
SN 0034-7752
J9 REV CHIM-BUCHAREST
JI Rev. Chim.
PD DEC
PY 2016
VL 67
IS 12
BP 2654
EP 2658
PG 5
WC Chemistry, Multidisciplinary; Engineering, Chemical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Engineering
GA EJ5BB
UT WOS:000393230400055
DA 2025-06-11
ER

PT J
AU East, C
   Willis, BL
   Barlow, CE
   Grannemann, BD
   FitzGerald, SJ
   DeFina, LF
   Trivedi, MH
AF East, Cara
   Willis, Benjamin L.
   Barlow, Carolyn E.
   Grannemann, Bruce D.
   FitzGerald, Shannon J.
   DeFina, Laura F.
   Trivedi, Madhukar H.
TI Depressive Symptoms and Metabolic Syndrome in Preventive Healthcare: The
   Cooper Center Longitudinal Study
SO METABOLIC SYNDROME AND RELATED DISORDERS
LA English
DT Article
ID MIDDLE-AGED WOMEN; PHYSICAL-ACTIVITY; OLDER-ADULTS; MAJOR DEPRESSION;
   DOSE-RESPONSE; MENTAL-HEALTH; FOLLOW-UP; CES-D; ASSOCIATION; MANAGEMENT
AB Background: Depression, metabolic syndrome, and reduced cardiorespiratory fitness (CRF) are known to increase the risk of developing diabetes and cardiovascular disease. The association among these factors in a generally healthy, active population with access to health care is not well defined.
   Methods: This was a cross-sectional analysis of data collected on 5,125 women and men during preventive care examinations at the Cooper Clinic from 2000 to 2008. The main outcome measures were depressive symptoms as assessed by the Centers for Epidemiologic Studies Depression Scale short form (CES-D-10) questionnaire, presence or absence of metabolic syndrome, and CRF as measured by a maximal exercise treadmill test.
   Results: Women and men who exhibited depressive symptoms had a statistically higher prevalence of metabolic syndrome compared to those who did not (for women, 15.4% versus 7.2%, P < 0.0001; for men, 31.6% versus 22.8%, P < 0.0001). Individuals with depressive symptoms had an increased frequency of higher waist circumference, higher triglycerides, and lower high-density lipoprotein. Women with depressive symptoms also had marginally higher fasting blood glucose levels. After adjusting for age and smoking status, the odds of metabolic syndrome in women with depressive symptoms was 2.81 [95% confidence interval (CI), 2.01-3.93] times the odds of metabolic syndrome in those without depressive symptoms, and in men with depressive symptoms, the odds were 1.69 (95% CI, 1.42-2.00) times the odds of metabolic syndrome in men without. When controlled for CRF level, the presence or absence of depressive symptoms on the presence of metabolic syndrome is attenuated but remains statistically significant in women.
   Conclusion: Even in a generally healthy population with access to health care, the presence of depressive symptoms was associated with increased metabolic syndrome.
C1 [Willis, Benjamin L.; Barlow, Carolyn E.; FitzGerald, Shannon J.; DeFina, Laura F.] Cooper Inst, Dallas, TX 75230 USA.
   [East, Cara] Baylor Jack & Jane Hamilton Heart & Vasc Hosp, Soltero Cardiovasc Res Ctr, Dallas, TX USA.
   [Grannemann, Bruce D.; Trivedi, Madhukar H.] Univ Texas SW Med Ctr Dallas, Dept Psychiat, Dallas, TX 75390 USA.
C3 Cooper Institute; University of Texas System; University of Texas
   Southwestern Medical Center Dallas
RP DeFina, LF (corresponding author), Cooper Inst, 12330 Preston Rd, Dallas, TX 75230 USA.
EM ldefina@cooperinst.org
RI wright, beth/V-7496-2019; Trivedi, Madhukar/A-9029-2013
OI Trivedi, Madhukar/0000-0002-2983-1110
FU Agency for Healthcare Research and Quality (AHRQ); Corcept Therapeutics,
   Inc.; Corcept Therapeutics, Inc., Cyberonics, Inc.; Merck; National
   Alliance for Research in Schizophrenia and Depression; National
   Institute of Mental Health; National Institute on Drug Abuse; Novartis;
   Pharmacia Upjohn; Predix Pharmaceuticals (Epix); Solvay Pharmaceuticals,
   Inc.; Targacept; Abbott Laboratories, Inc.; Abdi Ibrahim; Akzo (Organon
   Pharmaceuticals Inc.); AstraZeneca; Bristol-Myers Squibb Company;
   Cephalon, Inc.; Evotec; Fabre Kramer Pharmaceuticals, Inc.; Forest
   Pharmaceuticals; GlaxoSmithKline; Janssen Pharmaceutica Products; LP;
   Johnson Johnson PRD; Eli Lilly Company; Meade Johnson; Medtronic;
   Neuronetics; Otsuka Pharmaceuticals; Parke-Davis Pharmaceuticals, Inc.;
   Pfizer Inc.; Sepracor; SHIRE Development; VantagePoint; Wyeth-Ayerst
   Laboratories
FX Dr. Trivedi reports that he has received research support from the
   Agency for Healthcare Research and Quality (AHRQ), Corcept Therapeutics,
   Inc., Cyberonics, Inc., Merck, National Alliance for Research in
   Schizophrenia and Depression, National Institute of Mental Health,
   National Institute on Drug Abuse, Novartis, Pharmacia & Upjohn, Predix
   Pharmaceuticals (Epix), Solvay Pharmaceuticals, Inc., and Targacept. He
   has received consulting and speaker fees from Abbott Laboratories, Inc.,
   Abdi Ibrahim, Akzo (Organon Pharmaceuticals Inc.), AstraZeneca,
   Bristol-Myers Squibb Company, Cephalon, Inc., Evotec, Fabre Kramer
   Pharmaceuticals, Inc., Forest Pharmaceuticals, GlaxoSmithKline, Janssen
   Pharmaceutica Products, LP, Johnson & Johnson PRD, Eli Lilly & Company,
   Meade Johnson, Medtronic, Neuronetics, Otsuka Pharmaceuticals,
   Parke-Davis Pharmaceuticals, Inc., Pfizer Inc., Sepracor, SHIRE
   Development, VantagePoint, and Wyeth-Ayerst Laboratories.
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NR 41
TC 20
Z9 27
U1 0
U2 4
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-4196
EI 1557-8518
J9 METAB SYNDR RELAT D
JI Metab. Syndr. Relat. Disord.
PD OCT
PY 2010
VL 8
IS 5
BP 451
EP 457
DI 10.1089/met.2010.0017
PG 7
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Research & Experimental Medicine
GA 662LS
UT WOS:000282809400011
PM 20854094
DA 2025-06-11
ER

PT J
AU Lee, AMH
   Ng, CG
   Koh, OH
   Gill, JS
   Aziz, SA
AF Lee, Albert Muh Haur
   Ng, Chong Guan
   Koh, Ong Hui
   Gill, Jesjeet Singh
   Aziz, Salina Abdul
TI Metabolic Syndrome in First Episode Schizophrenia, Based on the National
   Mental Health Registry of Schizophrenia (NMHR) in a General Hospital in
   Malaysia: A 10-Year Retrospective Cohort Study
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Article
DE metabolic syndrome; schizophrenia; risk
ID PHYSICAL-ACTIVITY; SUBSTANCE-ABUSE; DRUG-NAIVE; VITAMIN-D; GLUCOSE;
   1ST-EPISODE; POPULATION; DEPRESSION; MORTALITY; DISEASE
AB Schizophrenia has been linked with various medical comorbidities, particularly metabolic syndrome. The number of studies on this aspect is lacking in Malaysia. (1) Objective: To investigate metabolic syndrome rates and its associated factors. (2) Method: This is the first 10-year retrospective-outcome study of patients with first episode schizophrenia in Malaysia. Out of 394 patients diagnosed with first episode schizophrenia and registered with the National Mental Health Registry of Schizophrenia (NMHR) in the General Hospital Kuala Lumpur (GHKL) in 2004-2005, 174 patients consented to participate in the study. They were interviewed using a Schizophrenia outcome questionnaire and the International Physical Activity Questionnaire (IPAQ). The diagnosis of metabolic syndrome was made using the National Cholesterol Education ProgramThird Adult Treatment Panel (NCEP ATP III). (3) Results: All patients' weight, body mass index, fasting blood sugar, and blood pressure are significantly increased. Sixty-three subjects (36.2%) developed metabolic syndrome while 36 (23.2%) were hypertensive, and 41 (28.1%) were diabetic. Use of fluphenthixol depot (CI = 1.05-5.09, OR: 0.84, p = 0.039), reduced physical activity (CI = 0.13-1.00, OR: -1.04, p = 0.049), and substance use disorder (CI = 1.40, 13.89, OR: 1.48, p = 0.012) were significantly associated with metabolic syndrome based on univariate analysis. In further multivariate analysis, comorbid substance abuse was the only significant factor associated with metabolic syndrome after adjusting for physical activity and intramuscular depot. (4) Conclusion: Patients with schizophrenia are at high risk of metabolic syndrome. It is important to address substance use problems as an important risk factor of this comorbidity.
C1 [Lee, Albert Muh Haur; Aziz, Salina Abdul] Hosp Kuala Lumpur, Dept Psychiat, Kuala Lumpur 50586, Malaysia.
   [Ng, Chong Guan; Koh, Ong Hui; Gill, Jesjeet Singh] Univ Malaya, Dept Psychol Med, Fac Med, Kuala Lumpur 50603, Malaysia.
C3 Universiti Malaya
RP Ng, CG (corresponding author), Univ Malaya, Dept Psychol Med, Fac Med, Kuala Lumpur 50603, Malaysia.
EM albert_imu@hotmail.com; chong_guan@um.edu.my; ohkoh@um.edu.my;
   jesjeet@um.edu.my; salinaziz@gmail.com
RI Ng, Chong/G-6170-2010; , Koh/B-8798-2010; Gill, Jesjeet
   Singh/B-8709-2010
OI Ng, Chong Guan/0000-0003-1755-9188; , Koh/0000-0001-7455-4178; Gill,
   Jesjeet Singh/0000-0002-1594-0084
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NR 48
TC 13
Z9 14
U1 1
U2 5
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD MAY
PY 2018
VL 15
IS 5
AR 933
DI 10.3390/ijerph15050933
PG 13
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA GJ3LS
UT WOS:000435197300101
PM 29735938
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Onat, A
   Ademoglu, E
   Karadeniz, Y
   Can, G
   Uzun, AO
   Simsek, B
   Kaya, A
AF Onat, Altan
   Ademoglu, Evin
   Karadeniz, Yusuf
   Can, Gunay
   Uzun, Ahmet Okan
   Simsek, Baris
   Kaya, Aysem
TI Population-based serum omentin-1 levels: paradoxical association with
   cardiometabolic disorders primarily in men
SO BIOMARKERS IN MEDICINE
LA English
DT Article; Proceedings Paper
CT 44th Congress of the International-Society-of-Oncology-and-Biomarkers
   (ISOBM)
CY SEP 07-10, 2017
CL Rio de Janeiro, BRAZIL
SP Int Soc Oncol & Biomarkers, European Grp Tumor Markers, Brazilian Soc Clin Pathol
DE autoimmunity; cardiometabolic risk; gender difference; lipoprotein(a);
   metabolic syndrome; omentin-1
ID METABOLIC SYNDROME; ADIPOSE-TISSUE; PLASMA-LEVELS; AUTOIMMUNE
   ACTIVATION; ADIPONECTIN LEVELS; CORONARY-DISEASE; HDL DYSFUNCTION; RISK;
   OBESITY; WOMEN
AB Aim: The conflicting relationships of serum omentin with inflammation markers and cardiometabolic disorders were investigated. Results & methods: Unselected 864 population-based middle-aged adults were cross-sectionally studied by sex-specific omentin tertiles. Men in the lowest omentin tertile (T1) had lower systolic blood pressure, HbA1c and glucose values and tended in T3 to higher lipoprotein(a) levels. Logistic regression analysis, adjusted for four covariates, revealed significant independent associations with the presence of hypertension and diabetes only in men. Sex-and age-adjusted odds ratio in gender combined for T2 & T3 versus T1 was 1.34 (95% CI: 1.00-1.79) for metabolic syndrome. Discussion & conclusion: The elicited adverse relationships of omentin-1 support the notion of oxidative stress-induced proinflammatory conversion of omentin, rendering loss of anti-inflammatory properties.
C1 [Onat, Altan] Istanbul Univ, Cerrahpasa Med Fac, Dept Cardiol, Istanbul, Turkey.
   [Ademoglu, Evin] Istanbul Univ, Istanbul Med Fac, Dept Biochem, Istanbul, Turkey.
   [Karadeniz, Yusuf] Ataturk Univ, Med Fac, Dept Endocrinol & Metab, Erzurum, Turkey.
   [Can, Gunay] Istanbul Univ, Cerrahpasa Med Fac, Dept Publ Hlth, Istanbul, Turkey.
   [Uzun, Ahmet Okan] State Hosp, Dept Cardiol, Antakya, Turkey.
   [Simsek, Baris] Siyami Ersek Ctr Cardiovasc Surg, Istanbul, Turkey.
   [Kaya, Aysem] Istanbul Univ, Inst Cardiol, Biochem Lab, Istanbul, Turkey.
C3 Istanbul University - Cerrahpasa; Istanbul University; Istanbul
   University; Ataturk University; Istanbul University; Istanbul University
   - Cerrahpasa; Dr. Siyami Ersek Cardiac & Vascular Surgery Training &
   Research Hospital; Istanbul University
RP Kaya, A (corresponding author), Istanbul Univ, Inst Cardiol, Biochem Lab, Istanbul, Turkey.
EM kaya64@istanbul.edu.tr
RI Karadeniz, Yusuf/JAC-5120-2023; Kaya, Aysem/N-4974-2015; Can,
   Günay/AAB-1669-2020; Ademoglu, Evin/AAD-8990-2020
OI Ademoglu, Evin/0000-0003-2933-3119; CAN, GUNAY/0000-0001-5815-6700;
   Kaya, Aysem/0000-0003-3137-821X; Karadeniz, Yusuf/0000-0002-6113-3259
FU Turkish Society of Cardiology, Istanbul, Turkey
FX Unconditional financial support was obtained from the Turkish Society of
   Cardiology, Istanbul, Turkey. The authors have no other relevant
   affiliations or financial involvement with any organization or entity
   with a financial interest in or financial conflict with the subject
   matter or materials discussed in the manuscript apart from those
   disclosed.
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NR 34
TC 6
Z9 6
U1 0
U2 11
PU FUTURE MEDICINE LTD
PI LONDON
PA UNITEC HOUSE, 3RD FLOOR, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON, N3
   1QB, ENGLAND
SN 1752-0363
EI 1752-0371
J9 BIOMARK MED
JI Biomark. Med.
PD FEB
PY 2018
VL 12
IS 2
BP 141
EP 149
DI 10.2217/bmm-2017-0197
PG 9
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Research & Experimental Medicine
GA FU7DW
UT WOS:000424013300007
PM 29327600
DA 2025-06-11
ER

PT J
AU Lopresti, AL
   Drummond, PD
AF Lopresti, Adrian L.
   Drummond, Peter D.
TI Obesity and psychiatric disorders: Commonalities in dysregulated
   biological pathways and their implications for treatment
SO PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
LA English
DT Review
DE Inflammation; Neuroprogression; Obesity; Oxidative stress; Psychiatric
   disorders; Weight loss
ID BODY-MASS INDEX; FAST-FOOD CONSUMPTION; SEVERE MENTAL-ILLNESS; INDUCED
   WEIGHT-GAIN; OXIDATIVE STRESS; NITROSATIVE STRESS; PHYSICAL-ACTIVITY;
   METABOLIC SYNDROME; BIPOLAR DISORDER; CALORIC RESTRICTION
AB Rates of obesity are higher than normal across a range of psychiatric disorders, including major depressive disorder, bipolar disorder, schizophrenia and anxiety disorders. While the problem of obesity is generally acknowledged in mental health research and treatment, an understanding of their bi-directional relationship is still developing. In this review the association between obesity and psychiatric disorders is summarised, with a specific emphasis on similarities in their disturbed biological pathways; namely neurotransmitter imbalances, hypothalamus-pituitary-adrenal axis disturbances, dysregulated inflammatory pathways, increased oxidative and nitrosative stress, mitochondrial disturbances, and neuroprogression. The applicability and effectiveness of weight-loss interventions in psychiatric populations are reviewed along with their potential efficacy in ameliorating disturbed biological pathways, particularly those mediating inflammation and oxidative stress. It is proposed that weight loss may not only be an effective intervention to enhance physical health but may also improve mental health outcomes and slow the rate of neuroprogressive disturbances in psychiatric disorders. Areas of future research to help expand our understanding of the relationship between obesity and psychiatric disorders are also outlined. (C) 2013 Elsevier Inc. All rights reserved.
C1 [Lopresti, Adrian L.; Drummond, Peter D.] Murdoch Univ, Sch Psychol, Perth, WA 6150, Australia.
C3 Murdoch University
RP Lopresti, AL (corresponding author), A 4-165 Summerlakes Pde Ballajura, Ballajura, WA 6066, Australia.
EM a.lopresti@murdoch.edu.au
OI Lopresti, Adrian/0000-0002-6409-7839
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NR 144
TC 182
Z9 203
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U2 51
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0278-5846
EI 1878-4216
J9 PROG NEURO-PSYCHOPH
JI Prog. Neuro-Psychopharmacol. Biol. Psychiatry
PD AUG 1
PY 2013
VL 45
BP 92
EP 99
DI 10.1016/j.pnpbp.2013.05.005
PG 8
WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA 202RW
UT WOS:000323238300013
PM 23685202
DA 2025-06-11
ER

PT J
AU Guijarro, SF
   Garcia, CM
   Pomarol-Clotet, E
   Lopez, ENE
   Marti, MDB
   Cuadra, MAR
AF Fernandez Guijarro, Sara
   Miguel Garcia, Carolina
   Pomarol-Clotet, Edith
   Egea Lopez, Elena Nunilon
   Burjales Marti, Maria Dolors
   Rigol Cuadra, Maria Assumpta
TI Metabolic Syndrome Screening in People With Severe Mental Illness:
   Results From Two Spanish Community Mental Health Centers
SO JOURNAL OF THE AMERICAN PSYCHIATRIC NURSES ASSOCIATION
LA English
DT Article
DE metabolic syndrome; screening; psychiatric nursing; mental health
   nursing; severe mental illness
ID PHYSICAL HEALTH; LIFE-STYLE; SCHIZOPHRENIA; PREVALENCE; INTERVENTIONS;
   ADULTS; RISK; CARE; DEFINITION; CONSUMERS
AB BACKGROUND: The excess of mortality in people with severe mental illness is due to unnatural causes such as accidents or suicides and natural causes such as metabolic syndrome. The presence of modifiable risk factors like tobacco consumption increases cardiovascular and metabolic risk. AIMS: The purpose of this study was to identify the prevalence of metabolic syndrome and other cardiovascular risk factors in people with severe mental illness. This study also aimed to identify the prevalence of patients receiving treatment for any metabolic syndrome risk factor. METHOD: A cross-sectional descriptive study was performed. A total of 125 participants from two community mental health centers in Spain were recruited. RESULTS: More than half of the participants (58.4%) were active smokers. The prevalence of metabolic syndrome was 60%. A total of 16.8% received previous treatment for hypertension, 17.6% for hypertriglyceridemia, and 11.2% for diabetes. No differences were found between centers (22.7% vs. 18.7%, p = .9). CONCLUSIONS: The findings underscore the importance of monitoring the physical health of patients on antipsychotic therapy. The identification and management of cardiovascular and metabolic risks factors is an essential part of nursing care for people with severe mental illness. Mental health nurses are ideally positioned to carry out this task by performing physical health screening, health education, and lifestyle interventions.
C1 [Fernandez Guijarro, Sara] Ramon & Cajal Hosp, Madrid, Spain.
   [Miguel Garcia, Carolina; Rigol Cuadra, Maria Assumpta] Univ Barcelona, Barcelona, Spain.
   [Pomarol-Clotet, Edith] FIDMAG Hermanas Hosp Res Fdn, Barcelona, Spain.
   [Egea Lopez, Elena Nunilon] Murcia Hlth Serv, Murcia, Spain.
   [Burjales Marti, Maria Dolors] Rovira & Virgili Univ, Tarragona, Spain.
C3 Hospital Universitario Ramon y Cajal; University of Barcelona;
   Universitat Rovira i Virgili
RP Guijarro, SF (corresponding author), Ramon & Cajal Hosp, Ctr Salud Mental Barajas, Ave Gen 5, Madrid 28042, Spain.
EM s.fguijarro@hotmail.com
RI Fernández, Sara/AAH-1827-2019
OI Pomarol-Clotet, Edith/0000-0002-8159-8563; fernandez guijarro,
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PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
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EI 1532-5725
J9 J AM PSYCHIAT NURSES
JI J. Am. Psych. Nurses Assoc.
PD MAR
PY 2020
VL 26
IS 2
BP 162
EP 171
DI 10.1177/1078390319826686
PG 10
WC Nursing; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Psychiatry
GA LA3KY
UT WOS:000523850500005
PM 30741068
DA 2025-06-11
ER

PT J
AU Das, D
   Shruthi, NR
   Banerjee, A
   Jothimani, G
   Duttaroy, AK
   Pathak, S
AF Das, Diptimayee
   Shruthi, Nagainallur Ravichandran
   Banerjee, Antara
   Jothimani, Ganesan
   Duttaroy, Asim K. K.
   Pathak, Surajit
TI Endothelial dysfunction, platelet hyperactivity, hypertension, and the
   metabolic syndrome: molecular insights and combating strategies
SO FRONTIERS IN NUTRITION
LA English
DT Review
DE metabolic syndrome; atherosclerotic cardiovascular disease;
   hypertension; endothelial dysfunction; platelet hyperactivity
ID FATTY LIVER-DISEASE; ALL-CAUSE MORTALITY; CARDIOVASCULAR RISK;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; MEDITERRANEAN DIET;
   CARDIOMETABOLIC RISK; BLOOD-PRESSURE; OBESITY; PREVALENCE
AB Metabolic syndrome (MetS) is a multifaceted condition that increases the possibility of developing atherosclerotic cardiovascular disease. MetS includes obesity, hypertension, dyslipidemia, hyperglycemia, endothelial dysfunction, and platelet hyperactivity. There is a concerning rise in the occurrence and frequency of MetS globally. The rising incidence and severity of MetS need a proactive, multipronged strategy for identifying and treating those affected. For many MetS patients, achieving recommended goals for healthy fat intake, blood pressure control, and blood glucose management may require a combination of medicine therapy, lifestyles, nutraceuticals, and others. However, it is essential to note that lifestyle modification should be the first-line therapy for MetS. In addition, MetS requires pharmacological, nutraceutical, or other interventions. This review aimed to bring together the etiology, molecular mechanisms, and dietary strategies to combat hypertension, endothelial dysfunction, and platelet dysfunction in individuals with MetS.
C1 [Das, Diptimayee; Shruthi, Nagainallur Ravichandran; Banerjee, Antara; Jothimani, Ganesan; Pathak, Surajit] Chettinad Acad Res & Educ, Chettinad Hosp & Res Inst, Fac Allied Hlth Sci, Kelambakkam, Tamil Nadu, India.
   [Duttaroy, Asim K. K.] Univ Oslo, Inst Med Sci, Fac Med, Dept Nutr, Oslo, Norway.
C3 University of Oslo
RP Pathak, S (corresponding author), Chettinad Acad Res & Educ, Chettinad Hosp & Res Inst, Fac Allied Hlth Sci, Kelambakkam, Tamil Nadu, India.; Duttaroy, AK (corresponding author), Univ Oslo, Inst Med Sci, Fac Med, Dept Nutr, Oslo, Norway.
EM a.k.duttaroy@medisin.uio.no; drsurajitpathak@care.edu.in
RI Duttaroy, Asim/J-9499-2016; Jothimani, Ganesan/AAG-4407-2020; Banerjee,
   Antara/AAH-4044-2020; Das, Diptimayee/LUY-3352-2024; Pathak,
   Surajit/AAH-4022-2020
OI Jothimani, Ganesan/0000-0003-3031-5620
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NR 262
TC 31
Z9 31
U1 4
U2 13
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD AUG 8
PY 2023
VL 10
AR 1221438
DI 10.3389/fnut.2023.1221438
PG 25
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA P6TC9
UT WOS:001051970900001
PM 37614749
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Haghighatdoost, F
   Azadbakht, L
   Keshteli, AH
   Feinle-Bisset, C
   Daghaghzadeh, H
   Afshar, H
   Feizi, A
   Esmaillzadeh, A
   Adibi, P
AF Haghighatdoost, Fahimeh
   Azadbakht, Leila
   Keshteli, Ammar Hassanzadeh
   Feinle-Bisset, Christine
   Daghaghzadeh, Hamed
   Afshar, Hamid
   Feizi, Awat
   Esmaillzadeh, Ahmad
   Adibi, Peyman
TI Glycemic index, glycemic load, and common psychological disorders
SO AMERICAN JOURNAL OF CLINICAL NUTRITION
LA English
DT Article
DE anxiety; depression; glycemic index; glycemic load; psychological
   distress
ID DEPRESSIVE SYMPTOMS; COGNITIVE PERFORMANCE; METABOLIC SYNDROME; GUT
   MICROBIOTA; MENTAL-HEALTH; DIET QUALITY; RISK-FACTORS; ASSOCIATION;
   METAANALYSIS; PREVALENCE
AB Background: Potential associations between dietary glycemic index (GI) and glycemic load (GL) with psychological disorders remain uncertain.
   Objective: We investigated the relations of dietary GI and GL with psychological distress, anxiety, and depression.
   Design: A total of 3363 nonacademic members of the staff of Isfahan University of Medical Sciences were included in this cross-sectional study. GI and GL were assessed by using a validated, self-administered, dish-based, semiquantitative food-frequency questionnaire. Validated Iranian versions of the Hospital Anxiety and Depression Scale and General Health Questionnaire-12 were used to assess anxiety, depression, and psychological distress.
   Results: After control for potential confounders, individuals in the top tertile of GI had greater odds of depression (OR: 1.44; 95% CI: 1.03, 2.02; P-trend = 0.03) and a trend for greater odds of anxiety (OR: 1.52; 95% CI: 0.97, 2.38; P trend = 0.06) compared with those in the first tertile. Higher GL values were linked to lower odds for mental disorders (OR: 0.66; 95% CI: 0.49, 0.90; P-trend = 0.009), depression (OR: 0.69; 95% CI: 0.51, 0.93; P-trend = 0.02), and psychological distress (OR: 0.67; 95% CI: 0.48, 0.92; P-trend = 0.01). Significant interactions were observed between GI and sex for depression (P = 0.01) and psychological distress (P = 0.046) in the crude model. In stratified analyses by sex, after control for potential confounders, a greater GI was linked to a higher odds of depression (OR: 1.52; 95% CI: 1.20, 1.94; P-trend = 0.001) and psychological distress (OR: 1.66; 95% CI: 1.28, 2.14; P-trend = 0.001) in women but not in men.
   Conclusion: Our findings support a direct link between the odds of depression and dietary GI but inverse associations between GL and mental disorders, depression, and psychological distress. This trial was registered at clinicaltrials.gov as NCT02362113.
C1 [Haghighatdoost, Fahimeh; Azadbakht, Leila; Esmaillzadeh, Ahmad] Isfahan Univ Med Sci, Food Secur Res Ctr, Esfahan, Iran.
   [Haghighatdoost, Fahimeh; Azadbakht, Leila] Isfahan Univ Med Sci, Dept Community Nutr, Sch Nutr & Food Sci, Esfahan, Iran.
   [Daghaghzadeh, Hamed; Afshar, Hamid; Adibi, Peyman] Isfahan Univ Med Sci, Integrat Funct Gastroenterol Res Ctr, Esfahan, Iran.
   [Feizi, Awat] Isfahan Univ Med Sci, Sch Hlth, Dept Biostat & Epidemiol, Esfahan, Iran.
   [Azadbakht, Leila] Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Community Nutr, Tehran, Iran.
   [Keshteli, Ammar Hassanzadeh] Univ Alberta, Dept Med, Edmonton, AB, Canada.
   [Feinle-Bisset, Christine] Univ Adelaide, Discipline Med, Adelaide, SA, Australia.
   [Feinle-Bisset, Christine] Univ Adelaide, Natl Hlth & Med Res Council, Ctr Res Excellence Translating Nutr Sci Good Hlth, Adelaide, SA, Australia.
C3 Isfahan University of Medical Sciences; Isfahan University of Medical
   Sciences; Isfahan University of Medical Sciences; Isfahan University of
   Medical Sciences; Tehran University of Medical Sciences; University of
   Alberta; University of Adelaide; National Health & Medical Research
   Council (NHMRC) of Australia; University of Adelaide
RP Azadbakht, L (corresponding author), Isfahan Univ Med Sci, Food Secur Res Ctr, Esfahan, Iran.
EM azadbakht@hlth.mui.ac.ir
RI afshar, hamid/AAC-7675-2020; Keshteli, Ammar/K-7473-2012; Adibi Sedeh,
   Peyman/AAJ-4582-2020; Azadbakht, Leila/N-2801-2018; daghaghzadeh,
   hamed/C-2133-2018; Esmaillzadeh, Ahmad/N-5704-2014; Feizi,
   Awat/W-3409-2017
OI Adibi Sedeh, Peyman/0000-0001-6411-5235; Azadbakht,
   Leila/0000-0002-5955-6818; daghaghzadeh, hamed/0000-0003-1259-7732;
   Hassanzadeh Keshteli, Ammar/0000-0001-7375-6210; Esmaillzadeh,
   Ahmad/0000-0002-8735-6047; Feizi, Awat/0000-0002-1930-0340
FU Isfahan University of Medical Sciences; National Health and Medical
   Research Council of Australia Senior Research Fellowship [627002]
FX Supported by Isfahan University of Medical Sciences. CF-B was supported
   by a National Health and Medical Research Council of Australia Senior
   Research Fellowship (grant 627002, 2010-15).
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NR 63
TC 64
Z9 67
U1 0
U2 29
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0002-9165
EI 1938-3207
J9 AM J CLIN NUTR
JI Am. J. Clin. Nutr.
PD JAN
PY 2016
VL 103
IS 1
BP 201
EP 209
DI 10.3945/ajcn.114.105445
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA DA5VA
UT WOS:000367869500024
PM 26607943
OA Bronze
DA 2025-06-11
ER

PT J
AU He, JX
   Liu, F
   Xu, PY
   Xu, T
   Yu, HY
   Wu, BH
   Wang, HB
   Chen, J
   Zhang, K
   Zhang, JB
   Meng, KK
   Yan, XQ
   Yang, QS
   Zhang, XX
   Sun, D
   Chen, X
AF He, Jiaxuan
   Liu, Fan
   Xu, Peiye
   Xu, Ting
   Yu, Haiyang
   Wu, Baihui
   Wang, Hanbing
   Chen, Jia
   Zhang, Kun
   Zhang, Junbei
   Meng, Kaikai
   Yan, Xiaoqing
   Yang, Qinsi
   Zhang, Xingxing
   Sun, Da
   Chen, Xia
TI Aerobic Exercise Improves the Overall Outcome of Type 2 Diabetes
   Mellitus Among People With Mental Disorders
SO DEPRESSION AND ANXIETY
LA English
DT Review
DE aerobic exercise; mental disorders; nonpharmacological intervention;
   pathogenesis; type 2 diabetes mellitus
ID RANDOMIZED CONTROLLED-TRIAL; BIPOLAR-DISORDER; PHYSICAL-ACTIVITY;
   METABOLIC SYNDROME; COGNITIVE IMPAIRMENT; STRUCTURED EXERCISE;
   NEUROTROPHIC FACTOR; OXIDATIVE STRESS; GLYCEMIC CONTROL; HPA-AXIS
AB The escalating global prevalence of type 2 diabetes mellitus (T2DM) and mental disorder (MD) including schizophrenia, bipolar disorder, major depressive disorder, and anxiety highlights the urgency for comprehensive therapeutic strategies. Aerobic exercise (AE) is a viable adjunct therapy, providing significant benefits for individuals dealing with both T2DM and MD. This review consolidates evidence on AE's role in alleviating the physiological and psychological effects of these comorbid conditions. It delves into the pathophysiological connections between T2DM and various MD, including depression, schizophrenia, anxiety, and bipolar disorder-emphasizing their reciprocal exacerbation. Key neurophysiological mechanisms through which AE confers benefits are explored, including neuroinflammation modulation, brain structure and neuroplasticity enhancement, growth factor expression regulation, and hypothalamic-pituitary-adrenal (HPA)/microbiota-gut-brain (MGB) axis normalization. Clinical results indicate that AE significantly improves both metabolic and psychological parameters in patients with T2DM and MD, providing a substantial argument for integrating AE into comprehensive treatment plans. Future research should aim to establish detailed, personalized exercise prescriptions and explore the long-term benefits of AE in this population. This review underscores the potential of AE to complement existing therapeutic modalities and enhance the management of patients with T2DM and MD.
C1 [He, Jiaxuan; Liu, Fan; Xu, Peiye; Xu, Ting; Yu, Haiyang; Wu, Baihui; Sun, Da] Wenzhou Univ, Inst Life Sci & Biomed, Collaborat Innovat Ctr Zhejiang Prov, Wenzhou 325035, Peoples R China.
   [Wang, Hanbing] Univ Hong Kong, Dept Biotechnol, Hong Kong 999077, Peoples R China.
   [Chen, Jia] Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Sichuan Prov Ctr Mental Hlth, Sch Med, Chengdu 611100, Peoples R China.
   [Zhang, Kun] Chongqing Univ, Three Gorges Hosp, Chongqing Municipal Clin Res Ctr Endocrinol & Meta, Chongqing 404000, Peoples R China.
   [Zhang, Junbei; Meng, Kaikai; Sun, Da; Chen, Xia] Wenzhou Med Univ, Yiwu Cent Hosp, Affiliated Yiwu Hosp, Dept Endocrinol, Yiwu 322000, Peoples R China.
   [Yan, Xiaoqing] Wenzhou Med Univ, Chinese Amer Res Inst Diabetic Complicat, Sch Pharmaceut Sci, Wenzhou 325035, Peoples R China.
   [Yang, Qinsi] Univ Chinese Acad Sci, Wenzhou Inst, Wenzhou 325000, Peoples R China.
   [Zhang, Xingxing] Wenzhou Med Univ, Affiliated Hosp 1, Dept Endocrinol & Metab, Wenzhou 325000, Peoples R China.
C3 Wenzhou University; University of Hong Kong; University of Electronic
   Science & Technology of China; Sichuan Provincial People's Hospital;
   Chongqing University; Wenzhou Medical University; Wenzhou Medical
   University; Chinese Academy of Sciences; University of Chinese Academy
   of Sciences, CAS; Wenzhou Medical University
RP Sun, D (corresponding author), Wenzhou Univ, Inst Life Sci & Biomed, Collaborat Innovat Ctr Zhejiang Prov, Wenzhou 325035, Peoples R China.; Sun, D; Chen, X (corresponding author), Wenzhou Med Univ, Yiwu Cent Hosp, Affiliated Yiwu Hosp, Dept Endocrinol, Yiwu 322000, Peoples R China.
EM sunday@wzu.edu.cn; cxljf2004@wmu.edu.cn
RI Sun, Da/GYE-0903-2022
OI wu, bai hui/0009-0008-9043-5097; xu, pei ye/0009-0003-9266-4794; he, jia
   xuan/0009-0000-8797-4606; Liu, Fan/0000-0001-5120-9048
FU Wenzhou University
FX This work was supported by the Jinhua Municipal Science and Technology
   Bureau Major Science and Technology Plan Project (2024-3-022), the
   National Natural Science Foundation of China (51901160), the Natural
   Science Foundation of Zhejiang Province (LY22H020005), the Chengdu
   Municipal Science and Technology Program (2022-YF05-02018-SN), and the
   Graduate Scientific Research Foundation of Wenzhou University
   (3162024003057, 3162024003056, and 3162024004102).
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NR 234
TC 0
Z9 0
U1 9
U2 9
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1091-4269
EI 1520-6394
J9 DEPRESS ANXIETY
JI Depress. Anxiety
PY 2024
VL 2024
IS 1
AR 6651804
DI 10.1155/da/6651804
PG 31
WC Psychology, Clinical; Psychiatry; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA Q7D8G
UT WOS:001386247000001
PM 40226688
OA hybrid
DA 2025-06-11
ER

PT J
AU Stalder, T
   Steudte-Schmiedgen, S
   Alexander, N
   Klucken, T
   Vater, A
   Wichmann, S
   Kirschbaum, C
   Miller, R
AF Stalder, Tobias
   Steudte-Schmiedgen, Susann
   Alexander, Nina
   Klucken, Tim
   Vater, Annika
   Wichmann, Susann
   Kirschbaum, Clemens
   Miller, Robert
TI Stress-related and basic determinants of hair cortisol in humans: A
   meta-analysis
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Review
DE Hair cortisol; Meta-analysis; Stress; Confounder; Validity
ID LONG-TERM CORTISOL; AWAKENING RESPONSE; SCALP HAIR; METABOLIC SYNDROME;
   MAJOR DEPRESSION; HPA AXIS; TRAUMA EXPOSURE; MENTAL-HEALTH; BIOMARKER;
   DISORDER
AB The analysis of hair cortisol concentrations (HCC) is a relatively new strategy to measure long-term cumulative cortisol levels, which is increasingly used in psychoneuroendocrinological research. Here, we conduct a first comprehensive meta-analysis of HCC research based on aggregated data from a total of 124 (sub)samples (66 independent studies; total N = 10,289). We seek to answer two central questions: (i) Which covariates and basic features of HCC need to be considered in future research? (ii) What are the main determinants of HCC in terms of chronic stress exposure and mental health? Concerning basic characteristics, our findings identify several covariates to be considered (age, sex, hair washing frequency, hair treatment, oral contraceptive use), confirm a decline of HCC from the first to the second proximal 3 cm hair segment, and show positive associations between HCC and short-term salivary cortisol measures. Regarding chronic stress, we show that stress-exposed groups on a whole exhibit 22% increased HCC. This long-term cortisol hypersecretion emerges particularly when stress is still ongoing at the time of study (+43% HCC) but is not present in conditions of past/absent stress (-9% HCC, n.s.). We also report evidence for 17%-reduced HCC in anxiety disorders, such as PTSD. Interestingly, no consistent associations with mood disorders and self-reports of perceived stress, depressiveness or social support are found. However, our findings reveal positive associations of HCC with stress-related anthropometric (body mass index, waist-to-hip ratio) and hemodynamic measures (systolic blood pressure). These meta-analytic results are discussed in the light of their practical implications and important areas for future inquiry are outlined. (C) 2017 Elsevier Ltd. All rights reserved.
C1 [Stalder, Tobias; Steudte-Schmiedgen, Susann; Alexander, Nina; Vater, Annika; Wichmann, Susann; Kirschbaum, Clemens; Miller, Robert] Tech Univ Dresden, Biol Psychol, Dresden, Germany.
   [Stalder, Tobias; Klucken, Tim] Univ Siegen, Clin Psychol, Adolf Reichwein Str 2a, D-57076 Siegen, Germany.
   [Alexander, Nina] Med Sch Hamburg, Differential & Personal Psychol, Hamburg, Germany.
   [Miller, Robert] Med Sch Berlin, Fac Nat Sci, Berlin, Germany.
C3 Technische Universitat Dresden; Universitat Siegen; MSH Medical School
   Hamburg
RP Stalder, T (corresponding author), Univ Siegen, Clin Psychol, Adolf Reichwein Str 2a, D-57076 Siegen, Germany.
EM tobias.stalder@psychologie.uni-siegen.de
RI Kirschbaum, Clemens/AAB-1752-2020; Miller, Robert/G-4473-2016;
   /HHZ-4248-2022; Klucken, Tim/F-7669-2013
OI Miller, Robert/0000-0002-8665-5248; Alexander, Nina/0009-0002-7412-0163;
   /0000-0002-1171-7133; Stalder, Tobias/0000-0001-7558-1274; Klucken,
   Tim/0000-0003-2433-6652
FU German Research Foundation (DFG) [STA 1213/5-1, SFB 940/2]
FX Susann Steudte-Schmiedgen was supported by the German Research
   Foundation (DFG; STA 1213/5-1). Robert Miller was supported by the
   German Research Foundation (DFG, SFB 940/2).
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NR 150
TC 635
Z9 677
U1 8
U2 216
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
EI 1873-3360
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD MAR
PY 2017
VL 77
BP 261
EP 274
DI 10.1016/j.psyneuen.2016.12.017
PG 14
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA EP4UJ
UT WOS:000397375100034
PM 28135674
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Ming, Z
   Legare, DJ
   Lautt, WW
AF Ming, Zhi
   Legare, Dallas J.
   Lautt, W. Wayne
TI Obesity, syndrome X, and diabetes: the role of HISS-dependent insulin
   resistance altered by sucrose, an antioxidant cocktail, and age
SO CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
LA English
DT Article
DE HOMA; nutrition; insulin sensitivity; HISS; postprandial; meal;
   metabolic syndrome; cardiometabolic risk; age
ID SENSITIVITY; SENSITIZATION; MEAL; RATS
AB Absence of meal-induced insulin sensitization (AMIS) results in a predictable progression of dysfunctions, including postprandial hyperglycemia, compensatory hyperinsulinemia, resultant hyperlipidemia, increased oxidative stress, and obesity, progressing to syndrome X and diabetes. To test the 'AMIS syndrome' hypothesis we used 3 known means of producing graded and progressive changes in meal-induced insulin sensitization in rats. We used an aging model (9. 26, and 52 weeks), associated with a slow development of AMIS a low-dose Sucrose supplement model to accelerate the development of AMIS; and an antioxidant cocktail (S-adenosylmethionine, vitamin E, and vitamin Q to protect against the effect of the sucrose oil meal-induced insulin sensitization. Adiposity was assessed from weighed regional fat masses and bioelectrical impedance. AMIS developed with age, was increased by Sucrose Supplementation, and was inhibited by the antioxidant cocktail. AMIS correlated With postprandial hyperglycemia, hyperinsulinemia. hyperlipidemia, and with adiposity (r(2) = 0.7-0.8) regardless of age or nutrient status. The range of degrees of AMIS. established over time with these models, afforded the tool with which to test the AMIS syndrome and further the argument that AMIS is the First metabolic defect that cumulatively leads to a predictable series of homeostatic disturbances and dysfunctions, including obesity and type 2 diabetes.
C1 [Ming, Zhi; Legare, Dallas J.; Lautt, W. Wayne] Univ Manitoba, Fac Med, Dept Pharmacol & Therapeut, Winnipeg, MB R3E 0T6, Canada.
C3 University of Manitoba
RP Lautt, WW (corresponding author), Univ Manitoba, Fac Med, Dept Pharmacol & Therapeut, 753 McDermot Ave, Winnipeg, MB R3E 0T6, Canada.
EM wlautt@cc.umanitoba.ca
RI Legare, Dallas/AAC-3234-2021; Lautt, W./AAC-6106-2021
OI Lautt, W. Wayne/0000-0002-7239-1798
FU Canadian Institutes of Health Research [FRN-82037, FRN84533]; Manitoba
   Health Research Council Regional C; Partnership Program; Canadian Liver
   Foundation; Canadian Diabetes Association
FX This study was funded by operating grants from the Canadian Institutes
   of Health Research (FRN-82037 and FRN84533) and the Manitoba Health
   Research Council Regional C; Partnership Program, the Canadian Liver
   Foundation, and the Canadian Diabetes Association. Manuscript
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   long-term care and monitoring of the animals provided by Gerry Nolette
   and the staff of Central Animal Care Services at the University of
   Manitoba. Related interests: W.W. Lautt and Z. Ming have a patent
   pending on the antioxidant cocktail.
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NR 20
TC 19
Z9 21
U1 0
U2 1
PU CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS
PI OTTAWA
PA 65 AURIGA DR, SUITE 203, OTTAWA, ON K2E 7W6, CANADA
SN 0008-4212
EI 1205-7541
J9 CAN J PHYSIOL PHARM
JI Can. J. Physiol. Pharmacol.
PD OCT
PY 2009
VL 87
IS 10
SI SI
BP 873
EP 882
DI 10.1139/Y09-079
PG 10
WC Pharmacology & Pharmacy; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Physiology
GA 524KV
UT WOS:000272143100016
PM 20052013
DA 2025-06-11
ER

PT J
AU Shyam, S
   Gómez-Martínez, C
   Paz-Graniel, I
   Gaforio, JJ
   Martínez-González, MA
   Corella, D
   Fitó, M
   Martínez, JA
   Alonso-Gómez, AM
   Wärnberg, J
   Vioque, J
   Romaguera, D
   López-Miranda, J
   Estruch, R
   Tinahones, FJ
   Santos-Lozano, JM
   Serra-Majem, JL
   Bueno-Cavanillas, A
   Tur, JA
   Sánchez, VM
   Pintó, X
   Ramos, M
   Vidal, J
   Alcarria, MM
   Daimiel, L
   Ros, E
   Fernandez-Aranda, F
   Nishi, SK
   Regata, OG
   Toledo, E
   Sorli, JV
   Castañer, O
   Garcia-Rios, A
   Valls-Enguix, R
   Perez-Farinos, N
   Zulet, MA
   Rayó-Gago, E
   Casas, R
   Rivera-Izquierdo, M
   Tojal-Sierra, L
   Damas-Fuentes, M
   Buil-Cosiales, P
   Fernández-Carrion, R
   Goday, A
   Peña-Orihuela, PJ
   Compañ-Gabucio, L
   Diez-Espino, J
   Tello, S
   González-Pinto, A
   de la O, V
   Delgado-Rodríguez, M
   Babio, N
   Salas-Salvadó, J
AF Shyam, Sangeetha
   Gomez-Martinez, Carlos
   Paz-Graniel, Indira
   Gaforio, Jose J.
   Martinez-Gonzalez, Miguel Angel
   Corella, Dolores
   Fito, Montserrat
   Martinez, J. Alfredo
   Alonso-Gomez, Angel M.
   Warnberg, Julia
   Vioque, Jesus
   Romaguera, Dora
   Lopez-Miranda, Jose
   Estruch, Ramon
   Tinahones, Francisco J.
   Santos-Lozano, Jose Manuel
   Serra-Majem, J. Luis
   Bueno-Cavanillas, Aurora
   Tur, Josep A.
   Sanchez, Vicente Martin
   Pinto, Xavier
   Ramos, Maria
   Vidal, Josep
   Alcarria, Maria Mar
   Daimiel, Lidia
   Ros, Emilio
   Fernandez-Aranda, Fernando
   Nishi, Stephanie K.
   Regata, Oscar Garcia
   Toledo, Estefania
   Sorli, Jose V.
   Castaner, Olga
   Garcia-Rios, Antonio
   Valls-Enguix, Rafael
   Perez-Farinos, Napoleon
   Zulet, M. Angeles
   Rayo-Gago, Elena
   Casas, Rosa
   Rivera-Izquierdo, Mario
   Tojal-Sierra, Lucas
   Damas-Fuentes, Miguel
   Buil-Cosiales, Pilar
   Fernandez-Carrion, Rebeca
   Goday, Albert
   Pena-Orihuela, Patricia J.
   Compan-Gabucio, Laura
   Diez-Espino, Javier
   Tello, Susanna
   Gonzalez-Pinto, Ana
   de la O, Victor
   Delgado-Rodriguez, Miguel
   Babio, Nancy
   Salas-Salvado, Jordi
TI Coronavirus disease 2019 is associated with long-term depressive
   symptoms in Spanish older adults with overweight/obesity and metabolic
   syndrome
SO PSYCHOLOGICAL MEDICINE
LA English
DT Article
DE COVID-19; depression; older adults; PREDIMED-Plus; SARS-CoV-2
AB Background. The coronavirus disease 2019 (COVID-19) has serious physiological and psychological consequences. The long-term (>12 weeks post-infection) impact of COVID19 on mental health, specifically in older adults, is unclear. We longitudinally assessed the association of COVID-19 with depression symptomatology in community-dwelling older adults with metabolic syndrome within the framework of the PREDIMED-Plus cohort.
   Methods. Participants (n = 5486) aged 55-75 years were included in this longitudinal cohort. COVID-19 status ( positive/negative) determined by tests (e.g. polymerase chain reaction severe acute respiratory syndrome coronavirus 2, IgG) was confirmed via event adjudication (410 cases). Pre- and post-COVID-19 depressive symptomatology was ascertained from annual assessments conducted using a validated 21-item Spanish Beck Depression Inventory-II (BDI-II). Multivariable linear and logistic regression models assessed the association between COVID-19 and depression symptomatology.
   Results. COVID-19 in older adults was associated with higher post-COVID-19 BDI-II scores measured at a median (interquartile range) of 29 (15-40) weeks post-infection [fully adjusted ss = 0.65 points, 95% confidence interval (CI) 0.15-1.15; p = 0.011]. This association was particularly prominent in women (ss = 1.38 points, 95% CI 0.44-2.33, p = 0.004). COVID-19 was associated with 62% increased odds of elevated depression risk (BDI-II >= 14) post-COVID-19 when adjusted for confounders (odds ratio; 95% CI 1.13-2.30, p = 0.008).
   Conclusions. COVID-19 was associated with long-term depression risk in older adults with overweight/obesity and metabolic syndrome, particularly in women. Thus, long-term evaluations of the impact of COVID-19 on mental health and preventive public health initiatives are warranted in older adults.
C1 [Shyam, Sangeetha; Gomez-Martinez, Carlos; Paz-Graniel, Indira; Martinez-Gonzalez, Miguel Angel; Corella, Dolores; Fito, Montserrat; Martinez, J. Alfredo; Alonso-Gomez, Angel M.; Warnberg, Julia; Romaguera, Dora; Lopez-Miranda, Jose; Estruch, Ramon; Tinahones, Francisco J.; Santos-Lozano, Jose Manuel; Serra-Majem, J. Luis; Tur, Josep A.; Pinto, Xavier; Daimiel, Lidia; Ros, Emilio; Fernandez-Aranda, Fernando; Nishi, Stephanie K.; Toledo, Estefania; Sorli, Jose V.; Garcia-Rios, Antonio; Perez-Farinos, Napoleon; Zulet, M. Angeles; Casas, Rosa; Tojal-Sierra, Lucas; Buil-Cosiales, Pilar; Fernandez-Carrion, Rebeca; Pena-Orihuela, Patricia J.; Diez-Espino, Javier; de la O, Victor; Babio, Nancy; Salas-Salvado, Jordi] Inst Hlth Carlos III, Ctr Invest Biomed Red Fisiopatol Obesidad & Nutr C, Madrid, Spain.
   [Shyam, Sangeetha; Gomez-Martinez, Carlos; Paz-Graniel, Indira; Nishi, Stephanie K.; Babio, Nancy; Salas-Salvado, Jordi] Univ Rovirai I Virgili, Dept Bioquim & Biotecnol, Grp Alimentacio Nutr Desenvolupament & Salut Menta, Unitat Nutr Humana, Reus, Spain.
   [Shyam, Sangeetha; Gomez-Martinez, Carlos; Paz-Graniel, Indira; Nishi, Stephanie K.; Babio, Nancy; Salas-Salvado, Jordi] Inst Invest Sanitaria Pere Virgili IISPV, Reus, Spain.
   [Gaforio, Jose J.; Vioque, Jesus; Bueno-Cavanillas, Aurora; Sanchez, Vicente Martin; Compan-Gabucio, Laura] Inst Salud Carlos III ISCIII, CIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain.
   [Gaforio, Jose J.] Univ Jaen, Inst Univ Invest Olivar & Aceites Oliva, Dept Ciencias Salud, Jaen, Spain.
   [Martinez-Gonzalez, Miguel Angel; Toledo, Estefania; Buil-Cosiales, Pilar; Diez-Espino, Javier] Univ Navarra, Dept Prevent Med & Publ Hlth, Inst Invest Sanitaria Navarra IdiSNA, Pamplona, Spain.
   [Martinez-Gonzalez, Miguel Angel] Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA.
   [Corella, Dolores; Sorli, Jose V.; Fernandez-Carrion, Rebeca] Univ Valencia, Dept Prevent Med, Valencia, Spain.
   [Fito, Montserrat; Castaner, Olga; Goday, Albert; Tello, Susanna] Inst Hosp del Mar Invest Med Municipal Invest Med, Unit Cardiovasc Risk & Nutr, Barcelona, Spain.
   [Martinez, J. Alfredo; Zulet, M. Angeles] Univ Navarra, Ctr Nutr Res, Dept Nutr Food Sci & Physiol, Pamplona, Spain.
   [Martinez, J. Alfredo; Sanchez, Vicente Martin; Delgado-Rodriguez, Miguel] CEI UAM CSIC, Precis Nutr & Cardiometab Hlth Program, IEA Food, Madrid, Spain.
   [Alonso-Gomez, Angel M.; Tojal-Sierra, Lucas] Araba Univ Hosp, Univ Basque Country UPV, Vitoria, Spain.
   [Alonso-Gomez, Angel M.; Tojal-Sierra, Lucas] Araba Univ Hosp, Osakidetza Basque Hlth Serv, Vitoria, Spain.
   [Alonso-Gomez, Angel M.; Tojal-Sierra, Lucas] Univ Basque Country UPV EHU, Vitoria, Spain.
   [Warnberg, Julia; Perez-Farinos, Napoleon] Univ Malaga, Sch Hlth Sci, Inst Invest Biomed Malaga IBIMA, EpiPHAAN Res Grp, Malaga, Spain.
   [Vioque, Jesus; Compan-Gabucio, Laura] Univ Miguel Hernandez ISABIAL UMH, Inst Invest Sanitaria & Biomed Alicante, Alicante, Spain.
   [Romaguera, Dora; Rayo-Gago, Elena] Hlth Res Inst Balearic Isl IdISBa, Palma De Mallorca, Spain.
   [Lopez-Miranda, Jose; Garcia-Rios, Antonio; Pena-Orihuela, Patricia J.] Univ Cordoba, Reina Sofia Univ Hosp, Dept Internal Med, Maimonides Biomed Res Inst Cordoba IMIBIC, Cordoba, Spain.
   [Estruch, Ramon; Casas, Rosa] Univ Barcelona, Hosp Clin, Inst Invest Biomed August Pi Sunyer IDIBAPS, Dept Internal Med, Barcelona, Spain.
   [Estruch, Ramon; Casas, Rosa] Univ Barcelona, Inst Recerca Nutr & Seguretat Alimentaria INSA UB, Barcelona, Spain.
   [Tinahones, Francisco J.; Damas-Fuentes, Miguel] Univ Malaga, Virgen de la Victoria Hosp, Dept Endocrinol, Inst Invest Biomed Malaga IBIMA, Malaga, Spain.
   [Santos-Lozano, Jose Manuel] Dist Sanitario Atenc Primaria Sevilla, Dept Familiy Med, Res Unit, Seville, Spain.
   [Serra-Majem, J. Luis] Univ Las Palmas Gran Canaria, Res Inst Biomed & Hlth Sci IUIBS, Las Palmas Gran Canaria, Spain.
   [Serra-Majem, J. Luis] Ctr Hosp Univ Insular Materno Infantil CHUIMI, Canarian Hlth Serv, Las Palmas Gran Canaria, Spain.
   [Bueno-Cavanillas, Aurora; Rivera-Izquierdo, Mario] Univ Granada, Dept Prevent Med & Publ Hlth, Granada, Spain.
   [Tur, Josep A.] Univ Balearic Isl, Res Grp Community Nutr & Oxidat Stress, Palma De Mallorca, Spain.
   [Sanchez, Vicente Martin] Univ Leon, Inst Biomed IBIOMED, Leon, Spain.
   [Pinto, Xavier] Hosp Univ Bellvitge IDIBELL, Internal Med, Lipids & Vasc Risk Unit, Hospitalet De Llobregat B, Barcelona, Spain.
   [Ramos, Maria] Inst Invest Sanitaria Hosp Clin San Carlos IdISSC, Dept Endocrinol & Nutr, Madrid, Spain.
   [Vidal, Josep] Inst Salud Carlos III ISCIII, CIBER Diabet & Enfermedades Metab CIBERDEM, Madrid, Spain.
   [Vidal, Josep] Univ Barcelona, Hosp Clin, Inst Invest Biomed August Pi Sunyer IDIBAPS, Dept Endocrinol, Barcelona, Spain.
   [Alcarria, Maria Mar] Univ Autonoma, Hosp Fdn Jimenez Diaz, Dept Endocrinol & Nutr, Inst Invest Biomed IISFJD, Madrid, Spain.
   [Daimiel, Lidia] CEI UAM CSIC, IMDEA Food, Precis Nutr & Obes Program, Nutr Contro,Epigenome Grp, Madrid, Spain.
   [Ros, Emilio] Hosp Clin Barcelona, Inst Invest Biomed August Pi Sunyer IDIBAPS, Dept Endocrinol & Nutr, Lipid Clin, Barcelona, Spain.
   [Daimiel, Lidia] Univ San Pablo CEU, CEU Univ, Fac Farm, Dept Ciencias Farmaceut & Salud, Boadilla Del Monte, Spain.
   [Fernandez-Aranda, Fernando] Inst Invest Biomed Bellvitge IDIBELL, Psychoneurobiol Eating & Addict Behav Grp, Barcelona, Spain.
   [Fernandez-Aranda, Fernando] Univ Hosp Bellvitge, Dept Psychiat, Barcelona, Spain.
   [Fernandez-Aranda, Fernando] Univ Barcelona, Barcelona, Spain.
   [Nishi, Stephanie K.] Toronto 3D Diet Digest Tract & Dis, Knowledge Synth & Clin Trials Unit, Toronto, ON, Canada.
   [Regata, Oscar Garcia] Univ Hosp Araba, Dept Internal Med, OSI ARABA, Vitoria, Spain.
   [Valls-Enguix, Rafael] Hlth Care Ctr Raval Elche, Elche, Spain.
   [Buil-Cosiales, Pilar; Diez-Espino, Javier] Serv Navarro Salud, Atenc Primaria, Pamplona, Spain.
   [Gonzalez-Pinto, Ana] Araba Univ Hosp, Bioaraba Hlth Res Inst, Dept Psychiat, Osakidetza Basque Hlth Serv, Vitoria, Spain.
   [Gonzalez-Pinto, Ana] Univ Basque Country UPV EHU, CIBERSAM, Vitoria, Spain.
   [Delgado-Rodriguez, Miguel] Univ Jaen, Fac Med, Div Prevent Med, Jaen, Spain.
C3 Universitat Rovira i Virgili; Institut d'Investigacio Sanitaria Pere
   Virgili (IISPV); CIBER - Centro de Investigacion Biomedica en Red;
   CIBERESP; Universidad de Jaen; University of Navarra; Harvard
   University; Harvard T.H. Chan School of Public Health; University of
   Valencia; University of Navarra; Consejo Superior de Investigaciones
   Cientificas (CSIC); University Hospital of Araba; University of Basque
   Country; University Hospital of Araba; University of Basque Country;
   Instituto de Investigacion Biomedica de Malaga y Plataforma en
   Nanomedicina (IBIMA); Universidad de Malaga; General University Hospital
   of Alicante; Universidad Miguel Hernandez de Elche; Universitat
   d'Alacant; Instituto de Investigacion Sanitaria y Biomedica de Alicante
   (ISABIAL); Institut Investigacio Sanitaria Illes Balears (IdISBa);
   Universidad de Cordoba; University of Barcelona; Hospital Clinic de
   Barcelona; IDIBAPS; University of Barcelona; Instituto de Investigacion
   Biomedica de Malaga y Plataforma en Nanomedicina (IBIMA); Universidad de
   Malaga; Universidad de Las Palmas de Gran Canaria; University of
   Granada; Universitat de les Illes Balears; Universidad de Leon; Institut
   d'Investigacio Biomedica de Bellvitge (IDIBELL); Bellvitge University
   Hospital; CIBER - Centro de Investigacion Biomedica en Red; CIBERDEM;
   University of Barcelona; Hospital Clinic de Barcelona; IDIBAPS;
   Autonomous University of Madrid; Fundacion Jimenez Diaz; Consejo
   Superior de Investigaciones Cientificas (CSIC); IMDEA Food Institute;
   University of Barcelona; Hospital Clinic de Barcelona; IDIBAPS; San
   Pablo CEU University; Institut d'Investigacio Biomedica de Bellvitge
   (IDIBELL); Institut d'Investigacio Biomedica de Bellvitge (IDIBELL);
   Bellvitge University Hospital; University of Barcelona; University of
   Barcelona; University Hospital of Araba; Servicio Navarro de Salud -
   Osasunbidea; Bioaraba Health Research Institute; University Hospital of
   Araba; University of Basque Country; CIBER - Centro de Investigacion
   Biomedica en Red; CIBERSAM; Universidad de Jaen
RP Shyam, S; Babio, N (corresponding author), Inst Hlth Carlos III, Ctr Invest Biomed Red Fisiopatol Obesidad & Nutr C, Madrid, Spain.; Shyam, S; Babio, N (corresponding author), Univ Rovirai I Virgili, Dept Bioquim & Biotecnol, Grp Alimentacio Nutr Desenvolupament & Salut Menta, Unitat Nutr Humana, Reus, Spain.; Shyam, S; Babio, N (corresponding author), Inst Invest Sanitaria Pere Virgili IISPV, Reus, Spain.
EM Sangeetha.shyam@urv.cat; nancy.babio@urv.cat
RI ALONSO GOMEZ, ANGEL/HLG-2476-2023; Tejada, Silvia/L-7297-2014; Martin,
   Vicente/A-1597-2008; Pintó, Xavier/AGI-4297-2022; Castaner,
   Olga/F-1533-2013; Paz-Graniel, Indira/ABH-2583-2020; Babio,
   Nancy/AAN-2715-2020; Estruch, Ramon/AAZ-3723-2020; Romaguera,
   Dora/ABE-7004-2020; Vioque, Jesus/A-1066-2008; Bueno-Cavanillas,
   Aurora/O-1513-2015; Corella, Dolores/L-9888-2014; Gabucio,
   Laura/AAN-6068-2020; Fernandez-Carrion, Rebeca/AAA-5713-2019; Rodríguez,
   Miguel/KCZ-1828-2024; Casas, Rosa/ABD-1915-2020; Tur,
   Josep/AAE-5748-2020; Martinez-Gonzalez, Miguel/AAE-7669-2019; Sorlí,
   José/L-8758-2014; Toledo, Estefania/H-6211-2014; Ortiz Ramos,
   María/GYV-2493-2022; Torres, Miguel/HZK-8113-2023; Lopez-Miranda,
   Jose/Y-8306-2019; Nishi, Stephanie/GSN-1143-2022; Tinahones,
   Francisco/AAB-2882-2020; Serra-Majem, Lluis/I-6708-2019; Daimiel-Ruiz,
   Lidia/M-7779-2014; Rivera-Izquierdo, Mario/AAJ-8726-2021; Vidal,
   Josep/MIK-6936-2025; Gomez Martinez, Carlos/AGJ-6387-2022; Fito Colomer,
   Montse/C-1822-2012; Delgado Rodriguez, Miguel/H-4940-2017;
   FERNANDEZ-ARANDA, FERNANDO/L-9762-2014; Salas-Salvado,
   Jordi/C-7229-2017; Shyam, Sangeetha/G-4636-2013
OI BABIO SANCHEZ, NANCY/0000-0003-3527-5277; Gomez Martinez,
   Carlos/0000-0002-3077-6702; Casas, Rosa/0000-0002-0211-9166; Pena
   Orihuela, Patricia J/0009-0009-9970-043X; Fito Colomer,
   Montse/0000-0002-1817-483X; Lopez-Miranda, Jose/0000-0002-8844-0718;
   Delgado Rodriguez, Miguel/0000-0002-3838-2548; Tojal Sierra,
   Lucas/0000-0001-5338-9601; Tinahones, Francisco J/0000-0001-6871-4403;
   Nishi, Stephanie/0000-0002-7878-5368; Sorli, Jose V/0000-0002-0130-2006;
   FERNANDEZ-ARANDA, FERNANDO/0000-0002-2968-9898; Paz Graniel,
   Indira/0000-0002-3204-6877; Ortiz Ramos, Maria/0000-0003-2187-8907;
   Salas-Salvado, Jordi/0000-0003-2700-7459; Shyam,
   Sangeetha/0000-0002-3340-1519
FU Fundacion Francisco Soria Melguizo; CIBER Fisiopatologia de la Obesidad
   y Nutricion (CIBEROBN); Instituto de Salud Carlos III (ISCIII);
   Implementacion y evaluacion de una intervencion intensiva sobre la
   actividad fisica Cohorte PREDIMED-Plus grant; European Research Council
   [340918]; Recercaixa [2013ACUP00194]; Consejeria de Salud de laJunta de
   Andalucia [PI0458/2013, PS0358/2016, PI0137/2018]; Generalitat
   Valenciana [PROMETEO/2017/017, PROMETEO 21/2021]; SEMERGEN grant; Juan
   de la Cierva-Incorporacion research grant of the Spanish Ministry of
   Economy, Industry and Competitiveness and European Social Funds
   [IJC2019-042420-I]; EU [H2020-SFS-2016-2]; Horizon 2020 PRIME study
   (Prevention and Remediation of Insulin Multimorbidity in Europe)
   [847879]; Maria Zambrano Fellowship; Ministry of Universities; Recovery,
   Transformation and Resilience Plan, Spain; European
   Union-NextGenerationEU; Canadian Institutes of Health Research(CIHR)
   [MFE-171207]; University of Rovira I Virgili [2020PMF-PIPF-37]; ICREA
FX This work was supported by a project grant from the Fundacion Francisco
   Soria Melguizo. The PREDIMED-Plus trial was supported by the official
   Spanish Institutions for funding scientific biomedical research, CIBER
   Fisiopatologia de la Obesidad y Nutricion (CIBEROBN) and Instituto de
   Salud Carlos III (ISCIII), through the Fondo de Investigacion para la
   Salud (FIS), which is co-funded by the European Regional Development
   Fund (six coordinated FIS projects leaded by J. S.-S.and J. Vi.,
   including the following projects: PI13/00673, PI13/00492, PI13/00272,
   PI13/01123, PI13/00462, PI13/00233, PI13/02184, PI13/00728, PI13/01090,
   PI13/01056, PI14/01722, PI14/00636, PI14/00618, PI14/00696, PI14/01206,
   PI14/01919, PI14/00853, PI14/01374, PI14/00972, PI14/00728, PI14/01471,
   PI16/00473, PI16/00662, PI16/01873, PI16/01094, PI16/00501, PI16/00533,
   PI16/00381, PI16/00366, PI16/01522, PI16/01120, PI17/00764, PI17/01183,
   PI17/00855, PI17/01347, PI17/00525, PI17/01827, PI17/00532, PI17/00215,
   PI17/01441, PI17/00508, PI17/01732, PI17/00926, PI19/00957, PI19/00386,
   PI19/00309, PI19/01032, PI19/00576, PI19/00017, PI19/01226, PI19/00781,
   PI19/01560, PI19/01332, PI20/01802, PI20/00138, PI20/01532, PI20/00456,
   PI20/00339, PI20/00557, PI20/00886, PI20/01158); the Especial &
   nbsp;Action Project entitled: Implementacion y evaluacion de una
   intervencion intensiva sobre la actividad fisica Cohorte PREDIMED-Plus
   grant to J. S.-S.; the European Research Council (Advanced Research
   Grant 2014-2019; agreement #340918) granted to M. A. M.-G.; the
   Recercaixa (number 2013ACUP00194) grant to J. S.-S.; grants from the
   Consejeria de Salud de laJunta de Andalucia (PI0458/2013, PS0358/2016,
   and PI0137/2018); the PROMETEO/2017/017 and PROMETEO 21/2021 grants from
   the Generalitat Valenciana; the SEMERGEN grant; Juan de la
   Cierva-Incorporacion research grant (IJC2019-042420-I) of the Spanish
   Ministry of Economy, Industry and Competitiveness and European Social
   Funds. This research was also partially funded by EU-H2020
   Grants(Eat2beNICE/ H2020-SFS-2016-2); and the Horizon 2020 PRIME study
   (Prevention and Remediation of Insulin Multimorbidity in Europe; grant
   agreement #847879). S. G. S. was a recipient of the Maria Zambrano
   Fellowship with funding support from the Ministry of Universities and
   the Recovery, Transformation and Resilience Plan, Spain. The Fellowship
   is Funded by the European Union-NextGenerationEU'. S. K. N. was
   supported by a postdoctoral fellowship from the Canadian Institutes of
   Health Research(CIHR, MFE-171207). C. G.-M. was supported by a
   predoctoral grant from the University of Rovira I Virgili
   (2020PMF-PIPF-37). J. S.-S. was partially supported by ICREA under the
   ICREA Academia program. We thank CERCA Programme/Generalitat de
   Catalunya for institutional support. The funders had no role in study
   design, data collection and analysis, the decision to publish, or the
   preparation of the manuscript
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NR 31
TC 5
Z9 5
U1 0
U2 16
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0033-2917
EI 1469-8978
J9 PSYCHOL MED
JI Psychol. Med.
PD FEB
PY 2024
VL 54
IS 3
BP 620
EP 630
DI 10.1017/S0033291723002313
EA SEP 2023
PG 11
WC Psychology, Clinical; Psychiatry; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA C7C7A
UT WOS:001067521900001
PM 37667630
DA 2025-06-11
ER

PT J
AU Làmbert, C
   Panagiotopoulos, C
   Davidson, J
   Goldman, RD
AF Lambert, Clare
   Panagiotopoulos, Constadina
   Davidson, Jana
   Goldman, Ran D.
TI Second-Generation Antipsychotic Use in Pediatric Emergency Medicine
SO PEDIATRIC EMERGENCY CARE
LA English
DT Review
DE second-generation antipsychotics; metabolic syndrome; SGA monitoring
ID MENTAL-HEALTH PROBLEMS; METABOLIC SYNDROME; CHILDREN; ADOLESCENTS;
   RECOMMENDATIONS; COMPLICATIONS; POPULATION; VISITS; YOUTH; RATES
AB In recent years, the number of patients presenting to the emergency department with mental health complaints has been growing, alongside an increase in second-generation antipsychotic (SGAs) prescriptions for a variety of mental health conditions. Children treated with SGAs may have abnormalities, such as rapid weight gain and central adiposity, glucose intolerance, dyslipidemia, and hypertension; they may present to the pediatric emergency department with components of metabolic syndrome or type 2 diabetes, and a subsequent significant risk for cardiovascular complications later in life. Pediatric emergency department providers may serve as a safety net for patients to detect SGA-related metabolic complications, especially among vulnerable populations lacking access to primary care or psychiatric services.
C1 [Lambert, Clare; Goldman, Ran D.] Univ British Columbia, Pediat Res Emergency Therapeut PRETx Program, Div Pediat Emergency Med, Vancouver, BC, Canada.
   [Panagiotopoulos, Constadina] Univ British Columbia, Dept Pediat, Div Endocrinol, Vancouver, BC, Canada.
   [Davidson, Jana] Univ British Columbia, Dept Psychiat, Vancouver, BC, Canada.
   [Goldman, Ran D.] BC Childrens Hosp Res Inst, Vancouver, BC, Canada.
C3 University of British Columbia; University of British Columbia;
   University of British Columbia; BC Children's Hospital; BC Children's
   Hospital Research Institute
RP Goldman, RD (corresponding author), BC Childrens Hosp, Div Pediat Emergency Med, Vancouver, BC, Canada.
EM ClareLambert@rcsi.ie; dpanagiotopoulos@cw.bc.ca; jxdavidson@cw.bc.ca;
   rgoldman@cw.bc.ca
RI Lambert, Clare/NCV-8868-2025; Panagiotopoulos, Constadina/AAO-6827-2020
OI Goldman, Ran D./0000-0001-8318-5415
CR [Anonymous], 2018, ORANGE BOOK DATABASE
   [Anonymous], 2020, PEDIAT PSYCHOPHARMAC
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NR 43
TC 1
Z9 1
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0749-5161
EI 1535-1815
J9 PEDIATR EMERG CARE
JI Pediatr. Emerg. Care
PD MAR
PY 2021
VL 37
IS 3
BP 161
EP 166
PG 6
WC Emergency Medicine; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Emergency Medicine; Pediatrics
GA SK9FG
UT WOS:000656523900018
PM 33651760
DA 2025-06-11
ER

PT J
AU Bujtor, M
AF Bujtor, Melissa
TI Can dietary intake protect against low-grade inflammation in children
   and adolescents?
SO BRAIN BEHAVIOR & IMMUNITY-HEALTH
LA English
DT Article
DE Dietary intake; Dietary pattern; Macronutrients; Biomarkers;
   Inflammation; CRP; Cytokine; Interleukin; Children; Adolescent
ID C-REACTIVE PROTEIN; GLYCEMIC-INDEX DIET; WHOLE-GRAIN INTAKE;
   CARDIOMETABOLIC RISK; SUBCLINICAL INFLAMMATION; CARDIOVASCULAR RISK;
   MEDITERRANEAN DIET; METABOLIC SYNDROME; FIBER INTAKE; NO ASSOCIATION
AB In children and adolescents, chronic low-grade inflammation has been implicated in the pathogenesis of co- and multi-morbid conditions to mental health disorders. Diet quality is a potential mechanism of action that can exacerbate or ameliorate low-grade inflammation; however, the exact way dietary intake can regulate the immune response in children and adolescents is still to be fully understood. In this review, I discuss the current observational and interventional evidence that supports a potential therapeutic role for dietary intake in the amelioration of low-grade inflammation and highlight the need to develop a better understanding of the biological mechanisms underlying and attenuating the associations between dietary intake and low-grade inflammation in children and adolescents.
C1 [Bujtor, Melissa] Kings Coll London, Div Psychol Med, Inst Psychiat Psychol & Neurosci, London, England.
   [Bujtor, Melissa] Deakin Univ, Inst Phys Act & Nutr Res, Sch Exercise & Nutr Sci, Melbourne, Vic, Australia.
C3 University of London; King's College London; Deakin University
RP Bujtor, M (corresponding author), Kings Coll London, Div Psychol Med, Inst Psychiat Psychol & Neurosci, London, England.; Bujtor, M (corresponding author), Deakin Univ, Inst Phys Act & Nutr Res, Sch Exercise & Nutr Sci, Melbourne, Vic, Australia.
EM melissa.bujtor@kcl.ac.uk
RI Bujtor, Melissa/HKV-1724-2023; Pariante, Carmine Maria/B-1297-2011
OI Pariante, Carmine Maria/0000-0002-9132-5091
FU UK Medical Research Council [MR/N029488/1]; European Union [848158]
FX Melissa Bujtor is funded by the UK Medical Research Council (grants
   MR/N029488/1). This project has received & nbsp; funding from the
   European Union's Horizon 2020 research and innovation programme under
   Grant Agreement No 848158.
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NR 122
TC 3
Z9 3
U1 2
U2 11
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2666-3546
J9 BRAIN BEHAV IMMUN-HL
JI Brain Behav. Immun.-Health
PD DEC
PY 2021
VL 18
AR 100369
DI 10.1016/j.bbih.2021.100369
PG 7
WC Immunology; Neurosciences; Psychiatry
WE Emerging Sources Citation Index (ESCI)
SC Immunology; Neurosciences & Neurology; Psychiatry
GA Q7GD4
UT WOS:001059160700015
PM 34825233
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Rosmond, R
AF Rosmond, R
TI Role of stress in the pathogenesis of the metabolic syndrome
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Review
DE disease; environment; genes; metabolic syndrome; obesity; stress
ID GLUCOCORTICOID-RECEPTOR GENE; PITUITARY-ADRENAL AXIS;
   INSULIN-RESISTANCE; ABDOMINAL OBESITY; SYNDROME-X; IN-VITRO; CORTISOL;
   DEXAMETHASONE; POLYMORPHISM; POPULATION
AB Excess body fat, obesity, is one of the most common disorders in clinical practice. In addition, there is a clustering of several risk factors with obesity, including hypertension, glucose intolerance, diabetes mellitus, and hyperlipidemia, which is observed more frequently than by chance alone. This has led to the suggestion that these represent a single syndrome and is referred to as the Metabolic Syndrome. A growing body of evidence suggests that glucocorticoid secretion is associated with this complex phenotype. Continuously changing and sometimes threatening external environment may, when the challenge exceeds a threshold, activate central pathways that stimulate the adrenals to release glucocorticoids. In this review, we will discuss how such processes mediate a pathogenetic role in the Metabolic Syndrome. (C) 2004 Elsevier Ltd. All rights reserved.
RP Lundvagen 6, S-43364 Savedalen, Sweden.
EM rolandrosmond@hotmail.com
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NR 90
TC 367
Z9 449
U1 0
U2 18
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
EI 1873-3360
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD JAN
PY 2005
VL 30
IS 1
BP 1
EP 10
DI 10.1016/j.psyneuen.2004.05.007
PG 10
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA 858TL
UT WOS:000224214700001
PM 15358437
DA 2025-06-11
ER

PT J
AU Sud, D
   Maidment, I
   Bradley, E
   Tritter, J
AF Sud, Dolly
   Maidment, Ian
   Bradley, Eleanor
   Tritter, Jonathan
TI The experiences of the caring dyad: (Un)articulated realities of living
   with cardiometabolic risk, metabolic syndrome and related diseases in
   severe mental illness
SO HEALTH EXPECTATIONS
LA English
DT Article
DE dyad; informal carer; patient; qualitative; relationship; schizophrenia;
   thematic analysis
ID SOCIAL SUPPORT; HEALTH-CARE; FOLLOW-UP; SCHIZOPHRENIA; INTERVENTION;
   PSYCHOSIS; MORTALITY; INTERDEPENDENCE; MANAGEMENT; OUTCOMES
AB Background Informal carers play an important role in the care of patients with mental illness. Little is known of the relationship experience of the patient and their informal carer (caring dyad) as the context for the intersection between physical and mental health. Aim This study aimed to explore the impact of comorbid cardiometabolic risk (CMR), metabolic syndrome (MetS) and related diseases and severe mental illness (SMI) on the caring dyad. Design Between October 2018 and March 2020, we conducted 11 in-depth semi-structured interviews across 6 adult caring dyads, interviewing each individual separately. Setting Dyads were recruited within the United Kingdom; informal carers were nominated by the patient as a person who provided a significant amount of support. Variable Being Studied Participants were asked about the impacts of illness and caring on daily life. Data Analysis Data were analysed at the dyad level using thematic analysis, comparing and contrasting responses from each individual. Results Themes were identified: enhanced closeness, dissonance and balance within the caring dyad. Discussion and Conclusions This study uses a particular population of patients with comorbid CMR factors, MetS and related diseases and SMI and their informal carers to explore the relevance and utility of caring dyads as an analytical framework to inform practice and policy. Future interventions should consider factors impacting on dyadic relationships to formulate effective and sustainable dyadic care and treatment to improve health outcomes for both patients with SMI and their informal carers. Patient/Public Involvement In this study, patients and informal carers were participants. Topic guides were piloted with a patient and informal carer.
C1 [Sud, Dolly; Maidment, Ian] Aston Univ, Coll Life & Hlth Sci, Aston Pharm Sch, Birmingham B4 7ET, W Midlands, England.
   [Sud, Dolly] Leicestershire Partnership NHS Trust, Glenfield Hosp Site, Bradgate Mental Hlth Site, Pharmacy Dept, Groby Rd, Leicester LE3 9EJ, Leics, England.
   [Bradley, Eleanor] Univ Worcester, Coll Life Hlth & Environm Sci, Grove, England.
   [Tritter, Jonathan] Aston Univ, Sch Humanities & Social Sci, Birmingham, W Midlands, England.
C3 Aston University; Leicestershire Partnership NHS Trust; University of
   Worcester; Aston University
RP Sud, D (corresponding author), Aston Univ, Coll Life & Hlth Sci, Aston Pharm Sch, Birmingham B4 7ET, W Midlands, England.; Sud, D (corresponding author), Leicestershire Partnership NHS Trust, Glenfield Hosp Site, Bradgate Mental Hlth Site, Pharmacy Dept, Groby Rd, Leicester LE3 9EJ, Leics, England.
EM sudd@aston.ac.uk
RI Sud, Dolly/I-5045-2017; Bradley, Eleanor/AAM-2207-2020
OI SUD, DOLLY/0000-0002-6867-1631; Bradley, Eleanor/0000-0001-5877-2298;
   Tritter, Jonathan Q/0000-0002-1651-2428; Tritter,
   Jonathan/0000-0001-6258-4628; Maidment, Ian/0000-0003-4152-9704
FU Charitable Funds Committee at Leicestershire Partnership NHS Trust;
   Aston University
FX Charitable Funds Committee at Leicestershire Partnership NHS Trust; 50th
   Anniversary Prize Studentship awarded by Aston University
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NR 49
TC 2
Z9 2
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1369-6513
EI 1369-7625
J9 HEALTH EXPECT
JI Health Expect.
PD OCT
PY 2021
VL 24
IS 5
BP 1821
EP 1832
DI 10.1111/hex.13322
EA AUG 2021
PG 12
WC Health Care Sciences & Services; Health Policy & Services; Public,
   Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services; Public, Environmental & Occupational
   Health
GA UZ1DD
UT WOS:000680096900001
PM 34339575
OA Green Published, Green Accepted, gold
DA 2025-06-11
ER

PT J
AU Helvaci, N
   Yildiz, BO
AF Helvaci, Nafiye
   Yildiz, Bulent Okan
TI Polycystic ovary syndrome and aging: Health implications after menopause
SO MATURITAS
LA English
DT Article
DE PCOS; Obesity; Hypertension; Cardiovascular disease; Cancer; Depression
ID CORONARY-ARTERY-DISEASE; OBSTRUCTIVE SLEEP-APNEA; ORAL-CONTRACEPTIVE
   USE; FOLLOW-UP; CARDIOVASCULAR-DISEASE; POSTMENOPAUSAL WOMEN;
   CARDIOMETABOLIC RISK; INSULIN-RESISTANCE; DIABETES-MELLITUS; PREVALENCE
AB Polycystic ovary syndrome (PCOS) is a common endocrine disorder with heterogenous clinical manifestations. The evidence indicates that PCOS is associated with long-term health risks including type 2 diabetes, metabolic syndrome, obstructive sleep apnea, endometrial cancer, and mood disorders. Although cardiometabolic risk factors are more common among women with PCOS, currently there is no strong evidence for increased cardiovascular morbidity and mortality in these patients. The effect of menopausal transition on the long-term health consequences of PCOS is mostly uncertain. The PCOS phenotype improves with aging in affected women. Accordingly, the differences in the cardiometabolic risk profiles of PCOS patients and of the general population seem to disappear after menopause. However, it is not clear whether this phenotype amelioration is associated with changes in other long-term health risks after the menopause. There are also gaps in our knowledge about the impact of long-term use of oral contraceptives on the prevalence of PCOS-related comorbidities. This review summarizes the current knowledge regarding the long-term health consequences of PCOS and their clinical implications in peri- and postmenopause, and highlights areas for future research.
C1 [Helvaci, Nafiye] Hitit Univ, Sch Med, Div Endocrinol & Metab, Corum, Turkey.
   [Yildiz, Bulent Okan] Hacettepe Univ, Sch Med, Div Endocrinol & Metab, Ankara, Turkey.
C3 Hitit University; Hacettepe University
RP Yildiz, BO (corresponding author), Hacettepe Univ, Sch Med, Dept Internal Med, Div Endocrinol & Metab, TR-06100 Ankara, Turkey.
EM yildizbo@yahoo.com
RI Yildiz, Bulent/ABD-7781-2020; Helvacı, Nafiye/GQQ-6956-2022
OI Yildiz, Bulent/0000-0003-1797-7662
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NR 71
TC 25
Z9 29
U1 1
U2 17
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0378-5122
EI 1873-4111
J9 MATURITAS
JI Maturitas
PD SEP
PY 2020
VL 139
BP 12
EP 19
DI 10.1016/j.maturitas.2020.05.013
PG 8
WC Geriatrics & Gerontology; Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology; Obstetrics & Gynecology
GA MW0UU
UT WOS:000556763600003
PM 32747035
DA 2025-06-11
ER

PT J
AU Sil, R
   Ray, D
   Chakraborti, AS
AF Sil, Rajarshi
   Ray, Doel
   Chakraborti, Abhay Sankar
TI Glycyrrhizin ameliorates insulin resistance, hyperglycemia, dyslipidemia
   and oxidative stress in fructose-induced metabolic syndrome-X in rat
   model
SO INDIAN JOURNAL OF EXPERIMENTAL BIOLOGY
LA English
DT Article
DE Metabolic syndrome; High fructose diet; Glycation; Insulin resistance;
   Peroxisome proliferator activated receptor gamma; Glucose transporter 4
ID DIABETIC-RATS; 18-BETA-GLYCYRRHETINIC ACID; HEMOGLOBIN; GLYCATION;
   GLUCOSE; IRON; PEROXIDES; DISEASE; PLASMA; DAMAGE
AB This study investigates if glycyrrhizin, a constituent of licorice (Glycyrrhiza glabra) root, is able to treat the complications (insulin resistance, hyperglycemia, dyslipidemia and oxidative stress) of metabolic syndrome. Metabolic syndrome was induced in rats by feeding a fructose-enriched (60%) diet for six weeks, after which single dose of glycyrrhizin (50 mg/kg body weight) was administered intraperitoneally. Different biochemical parameters from blood were estimated during three weeks after treatment. Then the rats were sacrificed to collect skeletal muscle tissue. Glycyrrhizin reduced the enhanced levels of blood glucose, insulin and lipids in metabolic syndrome group. Increased advanced glycation end products of hemoglobin, glycohemoglobin, hemoglobin-mediated iron release and iron-mediated free radical reactions (arachidonic acid and deoxyribose degradation) in metabolic syndrome were inhibited by glycyrrhizin treatment. Reduced activities of enzymatic antioxidants (superoxide dismutase and catalase) and elevated oxidative stress markers (malonaldehyde, fructosamine, hemoglobin carbonyl content and DNA damage) in metabolic syndrome were reversed to almost normal levels by glycyrrhizin. The decreased levels of peroxisome proliferator activated receptor gamma (PPAR gamma) and glucose transporter 4 (GLUT4) proteins in skeletal muscle of metabolic syndrome group were elevated by glycyrrhizin, indicating improved fatty acid oxidation and glucose homeostasis.
C1 [Sil, Rajarshi; Ray, Doel; Chakraborti, Abhay Sankar] Univ Calcutta, Dept Biophys Mol Biol & Bioinformat, Univ Coll Sci, Kolkata 700009, India.
C3 University of Calcutta
RP Chakraborti, AS (corresponding author), Univ Calcutta, Dept Biophys Mol Biol & Bioinformat, Univ Coll Sci, 92 Acharyya Prafulla Chandra Rd, Kolkata 700009, India.
EM ascbmbg@caluniv.ac.in
FU University Grants Commission, New Delhi, India; Council of Scientific
   and Industrial Research, New Delhi, India [38(1129)/03/EMR-II]; UGC-DSA;
   DST-FIST programme of the department
FX RS gets a Fellowship from the University Grants Commission, New Delhi,
   India. A part of the study was supported by a grant from the Council of
   Scientific and Industrial Research, New Delhi, India [grant No.
   38(1129)/03/EMR-II]. Financial assistance from UGC-DSA and DST-FIST
   programme of the department is thankfully acknowledged.
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NR 47
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Z9 44
U1 0
U2 8
PU NATL INST SCIENCE COMMUNICATION-NISCAIR
PI NEW DELHI
PA DR K S KRISHNAN MARG, PUSA CAMPUS, NEW DELHI 110 012, INDIA
SN 0019-5189
EI 0975-1009
J9 INDIAN J EXP BIOL
JI Indian J. Exp. Biol.
PD FEB
PY 2013
VL 51
IS 2
BP 129
EP 138
PG 10
WC Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics
GA 089IH
UT WOS:000314903700004
PM 23923606
DA 2025-06-11
ER

PT J
AU Liukkonen, T
   Räsänen, P
   Jokelainen, J
   Leinonen, M
   Järvelin, MR
   Meyer-Rochow, VB
   Timonen, M
AF Liukkonen, T.
   Rasanen, P.
   Jokelainen, J.
   Leinonen, M.
   Jarvelin, M. -R.
   Meyer-Rochow, V. B.
   Timonen, M.
TI The association between anxiety and C-reactive protein (CRP) levels:
   Results from the Northern Finland 1966 Birth Cohort Study
SO EUROPEAN PSYCHIATRY
LA English
DT Article
DE Anxiety disorders; Unipolar depression; Epidemiology; Neuroendogrinology
ID CORONARY-HEART-DISEASE; POSTTRAUMATIC-STRESS-DISORDER; HOPKINS SYMPTOM
   CHECKLIST-25; ACUTE MYOCARDIAL-INFARCTION; ORAL-CONTRACEPTIVE USE; MAJOR
   DEPRESSION; INFLAMMATORY MARKERS; RISK-FACTORS; PHYSICAL-ACTIVITY;
   INTERFERON-ALPHA
AB Background. - Anxiety frequently accompanies low-grade inflammation-associated conditions like depression, insulin resistance, coronary heart disease and metabolic syndrome. The association between anxiety and low-grade inflammation is, unlike between depression and low-grade inflammation, a very sparsely studied area in general populations. The aim of the present study was to investigate whether anxiety symptoms as well as comorbid anxiety and depressive symptoms are associated with low-grade inflammation at population level.
   Methods. - The general population-based Northern Finland 1966 Birth Cohort was followed until age 31 (n = 2688 males and 2837 females), when the highly sensitive CRP concentrations were measured. Anxiety and depressive symptoms were defined by Hopkins Symptom Checklist-25 (HSCL-25).
   Results. - After adjusting for confounders, logistic regression analyses showed that anxiety symptoms alone increased the probability for elevated hs-CRP levels (>3.0 mg/L) in males over two-fold (2.19 Cl 95% 1.08-4.46), while comorbid anxiety and depressive symptoms caused a 1.7-fold (1.76 Cl 95% 1.13-2.74) increase in the probability for elevated hs-CRP levels (1.0-3.0 mg/L).
   Conclusions. - Our results support the hypothesis that anxiety as well as comorbid anxiety and depression can be associated with an increased risk for low-grade inflammation in males at population level. (C) 2011 Elsevier Masson SAS. All rights reserved.
C1 [Liukkonen, T.] Savonlinna Cent Hosp, Dept Psychiat, Savonlinna 57120, Finland.
   [Liukkonen, T.; Jokelainen, J.; Jarvelin, M. -R.; Timonen, M.] Univ Oulu, Inst Hlth Sci, Oulu 90014, Finland.
   [Rasanen, P.] Univ Oulu, Dept Psychiat, Oulu 90014, Finland.
   [Jokelainen, J.] Oulu Univ Hosp, Unit Gen Practice, Oys 90029, Finland.
   [Leinonen, M.] Inst Hlth & Welf, Child & Adolescent Hlth & Wellbeing Unit, Oulu 90101, Finland.
   [Jarvelin, M. -R.] Univ London Imperial Coll Sci Technol & Med, Fac Med, Dept Epidemiol & Publ Hlth, London W21 PG, England.
   [Jarvelin, M. -R.] Univ Oulu, Bioctr Oulu, Oulu 90014, Finland.
   [Jarvelin, M. -R.] Natl Inst Hlth & Welf, Lifecourse & Serv Dept, Oulu 90101, Finland.
   [Meyer-Rochow, V. B.] Univ Bremen, Sch Sci & Engn, D-28725 Bremen, Germany.
   [Meyer-Rochow, V. B.] Univ Oulu, Dept Physiol, Oulu 90014, Finland.
   [Timonen, M.] Oulu Hlth Ctr, Oulu 90015, Finland.
C3 University of Oulu; University of Oulu; University of Oulu; Imperial
   College London; University of Oulu; Finland National Institute for
   Health & Welfare; University of Bremen; University of Oulu
RP Liukkonen, T (corresponding author), Savonlinna Cent Hosp, Dept Psychiat, Keskussairaalantie 6, Savonlinna 57120, Finland.
EM timo.liukkonen@isshp.fi
RI MEYER-ROCHOW, Victor/AAJ-7258-2020
OI Jokelainen, Jari/0000-0003-4629-0560; MEYER-ROCHOW, V.
   Benno/0000-0003-1531-9244; Jarvelin, Marjo-Riitta/0000-0002-2149-0630
FU Finnish Cultural Foundation; Academy of Finland; Ministry of Health and
   Wellbeing; National Institute of Health; Oulu University Hospital;
   University of Oulu
FX This study was supported by the Finnish Cultural Foundation (Liukkonen),
   the Academy of Finland (Jarvelin), the Ministry of Health and Wellbeing
   (Jarvelin), the National Institute of Health (Jarvelin), Oulu University
   Hospital and the University of Oulu (Jarvelin).
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NR 79
TC 106
Z9 115
U1 0
U2 21
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0924-9338
EI 1778-3585
J9 EUR PSYCHIAT
JI Eur. Psychiat.
PD SEP
PY 2011
VL 26
IS 6
BP 363
EP 369
DI 10.1016/j.eurpsy.2011.02.001
PG 7
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 824GP
UT WOS:000295190700004
PM 21570260
DA 2025-06-11
ER

PT J
AU Minehira, K
   Tappy, L
AF Minehira, K
   Tappy, L
TI Dietary and lifestyle interventions in the management of the metabolic
   syndrome: present status and future perspective
SO EUROPEAN JOURNAL OF CLINICAL NUTRITION
LA English
DT Article
DE insulin resistance; fat intake; intramyocellular lipid; free fatty acid;
   exercise
ID FREE FATTY-ACIDS; INSULIN-RESISTANCE; GLUCOSE-METABOLISM; MENTAL STRESS;
   HEALTHY-MEN; SENSITIVITY; MECHANISMS; DISEASE; MUSCLE; HYPERTENSION
AB Objective: To review the mechanisms underlying the metabolic syndrome, or syndrome X, in humans, and to delineate dietary and environmental strategies for its prevention.
   Design: Review of selected papers of the literature.
   Results: Hyperinsulinemia and insulin resistance play a key role in the development of the metabolic syndrome. Strategies aimed at reducing insulin resistance may be effective in improving the metabolic syndrome. They include low saturated fat intake, consumption of low-glycemic-index foods, physical exercise and prevention of obesity.
   Conclusions: Future research, in particular the genetic basis of the metabolic syndrome and the interorgan interactions responsible for insulin resistance, is needed to improve therapeutic strategies for the metabolic syndrome.
C1 Univ Lausanne, Inst Physiol, CH-1005 Lausanne, Switzerland.
C3 University of Lausanne
RP Univ Lausanne, Inst Physiol, 7 Rue Bugnon, CH-1005 Lausanne, Switzerland.
EM luc.tappy@iphysiol.unil.ch
RI Tappy, Luc/A-8911-2017
OI Tappy, Luc/0000-0001-8469-4692
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NR 44
TC 22
Z9 26
U1 0
U2 1
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0954-3007
EI 1476-5640
J9 EUR J CLIN NUTR
JI Eur. J. Clin. Nutr.
PD DEC
PY 2002
VL 56
IS 12
DI 10.1038/sj.ejcn.1601645
PG 6
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 638LL
UT WOS:000180572400012
DA 2025-06-11
ER

PT J
AU Philip, J
   Ryman, TK
   Hopkins, SE
   O'Brien, DM
   Bersamin, A
   Pomeroy, J
   Thummel, KE
   Austin, MA
   Boyer, BB
   Dombrowski, K
AF Philip, Jacques
   Ryman, Tove K.
   Hopkins, Scarlett E.
   O'Brien, Diane M.
   Bersamin, Andrea
   Pomeroy, Jeremy
   Thummel, Kenneth E.
   Austin, Melissa A.
   Boyer, Bert B.
   Dombrowski, Kirk
TI Bi-cultural dynamics for risk and protective factors for cardiometabolic
   health in an Alaska Native (Yup'ik) population
SO PLOS ONE
LA English
DT Article
ID DENSITY-LIPOPROTEIN CHOLESTEROL; YUKON-KUSKOKWIM DELTA; MARINE
   FOOD-INTAKE; METABOLIC SYNDROME; CARDIOVASCULAR-DISEASE; BLOOD-PRESSURE;
   MENTAL-HEALTH; INUIT YOUTH; EICOSAPENTAENOIC ACID; DOCOSAHEXAENOIC ACID
AB Alaska Native people experience disparities in mortality from heart disease and stroke. This work attempts to better understand the relationships between socioeconomic, behavioral, and cardiometabolic risk factors among Yup'ik people of southwestern Alaska, with a focus on the role of the socioeconomic, and cultural components. Using a cross-sectional sample of 486 Yup'ik adults, we fitted a Partial Least Squares Path Model (PLS-PM) to assess the associations between components, including demographic factors [age and gender], socioeconomic factors [education, economic status, Yup'ik culture, and Western culture], behavioral factors [diet, cigarette smoking and smokeless tobacco use, and physical activity], and cardiometabolic risk factors [adiposity, triglyceride-HDL and LDL lipids, glycemia, and blood pressure]. We found relatively mild associations of education and economic status with cardiometabolic risk factors, in contrast with studies in other populations. The socioeconomic factor and participation in Yup'ik culture had potentially protective associations with adiposity, triglyceride-HDL lipids, and blood pressure, whereas participation in Western culture had a protective association with blood pressure. We also found a moderating effect of participation in Western culture on the relationships between Yup'ik culture participation and both blood pressure and LDL lipids, indicating a potentially beneficial additional effect of biculturalism. Our results suggest that reinforcing protective effects of both Yup'ik and Western cultures could be useful for interventions aimed at reducing cardiometabolic health disparities.
C1 [Philip, Jacques; Hopkins, Scarlett E.; O'Brien, Diane M.; Bersamin, Andrea; Boyer, Bert B.] Univ Alaska Fairbanks, Ctr Alaska Native Hlth Res, Fairbanks, AK 99775 USA.
   [Ryman, Tove K.] Bill & Melinda Gates Fdn, Seattle, WA USA.
   [Pomeroy, Jeremy] Marshfield Clin Fdn Med Res & Educ, Res Inst, Marshfield, WI USA.
   [Thummel, Kenneth E.] Univ Washington, Dept Pharmaceut, Seattle, WA 98195 USA.
   [Austin, Melissa A.] Univ Washington, Sch Publ Hlth, Dept Epidemiol, Seattle, WA 98195 USA.
   [Dombrowski, Kirk] Univ Nebraska, Dept Sociol, Lincoln, NE 68588 USA.
C3 University of Alaska System; University of Alaska Fairbanks; Bill &
   Melinda Gates Foundation; Marshfield Clinic; University of Washington;
   University of Washington Seattle; University of Washington; University
   of Washington Seattle; University of Nebraska System; University of
   Nebraska Lincoln
RP Philip, J (corresponding author), Univ Alaska Fairbanks, Ctr Alaska Native Hlth Res, Fairbanks, AK 99775 USA.
EM jphilip@alaska.edu
RI O'Brien, Diane/B-2919-2010
FU National Institute of Health [P20RR016430, P30GM103325, R01DK074842,
   U01GM092676, U54GM115371, U54GM104944]
FX The study was funded by the following grants from the National Institute
   of Health: P20RR016430, P30GM103325, R01DK074842, U01GM092676,
   U54GM115371, U54GM104944.
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NR 117
TC 6
Z9 6
U1 0
U2 11
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD NOV 1
PY 2017
VL 12
IS 11
AR e018345
DI 10.1371/journal.pone.0183451
PG 24
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Science & Technology - Other Topics
GA FL4VN
UT WOS:000414229700001
PM 29091709
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Ware, WR
AF Ware, William R.
TI Psychological stress, insulin resistance, inflammation and the
   assessment of heart disease risk. Time for a paradigm shift?
SO MEDICAL HYPOTHESES
LA English
DT Article
ID CORONARY-ARTERY CALCIFICATION; C-REACTIVE PROTEIN; DENSITY-LIPOPROTEIN
   CHOLESTEROL; ELECTRON-BEAM TOMOGRAPHY; DIURNAL CORTISOL DECLINE;
   CARDIOVASCULAR-DISEASE; PRIMARY PREVENTION; METABOLIC SYNDROME;
   MYOCARDIAL-INFARCTION; AORTIC CALCIFICATION
AB There is growing evidence that the present risk assessment protocol for coronary heart disease appears to underestimate the risk in general and the presence and progression of atherosclerosis in particular. Little or no correlation has been found between the 10-year risk based on the Framingham model and the extent or progression of coronary calcification. In addition, a number of studies find the protocol based on current guidelines leads to an under appreciation of the risk of symptomatic coronary heart disease or the associated fatal and non-fatal events, especially in younger asymptomatic individuals and women. Furthermore, the current guidelines give secondary importance to insulin resistance and inflammation and do not include psychosocial stress and depression, both of which are established and important risk factors for coronary heart disease. An alternative approach to risk assessment is proposed which emphasizes insulin resistance and psychological stress and depression and gives much greater recognition to inflammation as a root cause and target for intervention than is found in current guidelines. Consistent with this view, a revised assessment protocol is suggested which is still appropriate to the primary care setting and which might provide a different and perhaps more effective and relevant approach to primary prevention and risk reduction. (c) 2008 Elsevier Ltd. All rights reserved.
C1 Univ Western Ontario, Fac Sci Emeritus, London, ON, Canada.
C3 Western University (University of Western Ontario)
RP Ware, WR (corresponding author), Univ Western Ontario, Fac Sci Emeritus, London, ON, Canada.
EM warewr@rogers.com
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NR 96
TC 9
Z9 9
U1 0
U2 4
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0306-9877
EI 1532-2777
J9 MED HYPOTHESES
JI Med. Hypotheses
PY 2008
VL 71
IS 1
BP 45
EP 52
DI 10.1016/j.mehy.2008.02.008
PG 8
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 316XK
UT WOS:000256982800008
PM 18406066
DA 2025-06-11
ER

PT J
AU Jansen, R
   Han, LKM
   Verhoeven, JE
   Aberg, KA
   van den Oord, ECGJ
   Milaneschi, Y
   Penninx, BWJH
AF Jansen, Rick
   Han, Laura K. M.
   Verhoeven, Josine E.
   Aberg, Karolina A.
   van den Oord, Edwin C. G. J.
   Milaneschi, Yuri
   Penninx, Brenda W. J. H.
TI An integrative study of five biological clocks in somatic and mental
   health
SO ELIFE
LA English
DT Article
ID DNA METHYLATION AGE; LEUKOCYTE TELOMERE LENGTH; ALL-CAUSE MORTALITY;
   PSYCHIATRIC-DISORDERS; ALCOHOL-CONSUMPTION; EPIGENETIC CLOCK;
   SEX-DIFFERENCES; METAANALYSIS; ANXIETY; ASSOCIATIONS
AB Biological clocks have been developed at different molecular levels and were found to be more advanced in the presence of somatic illness and mental disorders. However, it is unclear whether different biological clocks reflect similar aging processes and determinants. In similar to 3000 subjects, we examined whether five biological clocks (telomere length, epigenetic, transcriptomic, proteomic, and metabolomic clocks) were interrelated and associated to somatic and mental health determinants. Correlations between biological aging indicators were small (all r < 0.2), indicating little overlap. The most consistent associations of advanced biological aging were found for male sex, higher body mass index (BMI), metabolic syndrome, smoking, and depression. As compared to the individual clocks, a composite index of all five clocks showed most pronounced associations with health determinants. The large effect sizes of the composite index and the low correlation between biological aging indicators suggest that one's biological age is best reflected by combining aging measures from multiple cellular levels.
C1 [Jansen, Rick; Han, Laura K. M.; Verhoeven, Josine E.; Milaneschi, Yuri; Penninx, Brenda W. J. H.] Vrije Univ Amsterdam, Amsterdam Publ Hlth Res Inst & Amsterdam Neurosci, Dept Psychiat, Amsterdam UMC, Amsterdam, Netherlands.
   [Aberg, Karolina A.; van den Oord, Edwin C. G. J.] Virginia Commonwealth Univ, Ctr Biomarker Res & Precis Med, Richmond, VA USA.
C3 University of Amsterdam; Vrije Universiteit Amsterdam; Virginia
   Commonwealth University
RP Jansen, R (corresponding author), Vrije Univ Amsterdam, Amsterdam Publ Hlth Res Inst & Amsterdam Neurosci, Dept Psychiat, Amsterdam UMC, Amsterdam, Netherlands.
EM ri.jansen@ggzingeest.nl
RI Jansen, Ritsert/C-1160-2013; Penninx, Brenda/S-7627-2017; Han,
   Laura/AGV-3472-2022; Aberg, Karolina/A-6772-2010
OI Jansen, Rick/0000-0002-3333-6737; Han, Laura/0000-0001-9647-3723;
   Milaneschi, Yuri/0000-0002-3697-6617
FU Netherlands Organisation for Health Research and Development (ZonMw)
   [10-000-1002]; VU University Medical Center; GGZ inGeest; Leiden
   University Medical Center; Leiden University; GGZ Rivierduinen;
   University Medical Center Groningen; University of Groningen; Lentis;
   GGZ Friesland; GGZ Drenthe; Rob Giel Onderzoekscentrum; NWO-VICI
   [91811602]; NIMH [R01MH099110]; BBMRI-NL; Dutch government (NWO)
   [184.021.007, 184033111]; US National Institute of Mental Health
   [RC2MH089951]
FX The infrastructure for the NESDA study (http://www.nesda.nl) is funded
   through the Geestkracht program of the Netherlands Organisation for
   Health Research and Development (ZonMw, grant number 10-000-1002) and
   financial contributions by participating universities and mental health
   care organizations (VU University Medical Center, GGZ inGeest, Leiden
   University Medical Center, Leiden University, GGZ Rivierduinen,
   University Medical Center Groningen, University of Groningen, Lentis,
   GGZ Friesland, GGZ Drenthe, Rob Giel Onderzoekscentrum). Telomere length
   assaying was supported through a NWO-VICI grant (number 91811602).
   Methylation sequencing was supported by NIMH grant R01MH099110.
   Metabolomics data were generated within the framework of the BBMRI
   Metabolomics Consortium funded by BBMRI-NL, a research infrastructure
   financed by the Dutch government (NWO, grant nr 184.021.007 and
   184033111). Gene expression data were funded by the US National
   Institute of Mental Health (RC2MH089951).
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NR 73
TC 59
Z9 63
U1 4
U2 20
PU eLIFE SCIENCES PUBL LTD
PI CAMBRIDGE
PA SHERATON HOUSE, CASTLE PARK, CAMBRIDGE, CB3 0AX, ENGLAND
SN 2050-084X
J9 ELIFE
JI eLife
PD FEB 9
PY 2021
VL 10
AR e59479
DI 10.7554/eLife.59479
PG 20
WC Biology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Life Sciences & Biomedicine - Other Topics
GA QI2YZ
UT WOS:000618847100001
PM 33558008
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Buchmann, AF
   Kopf, D
   Westphal, S
   Lederbogen, F
   Banaschewski, T
   Esser, G
   Schmidt, MH
   Zimmermann, US
   Laucht, M
   Deuschle, M
AF Buchmann, Arlette F.
   Kopf, Daniel
   Westphal, Sabine
   Lederbogen, Florian
   Banaschewski, Tobias
   Esser, Guenter
   Schmidt, Martin H.
   Zimmermann, Ulrich S.
   Laucht, Manfred
   Deuschle, Michael
TI Impact of Early Parental Child-Rearing Behavior on Young Adults'
   Cardiometabolic Risk Profile: A Prospective Study
SO PSYCHOSOMATIC MEDICINE
LA English
DT Article
DE child-rearing behavior; metabolic risk factors; longitudinal study
ID LIPOPROTEIN CHOLESTEROL LEVELS; INSULIN-RESISTANCE SYNDROME; BLOOD LIPID
   CONCENTRATIONS; CORONARY HEART-DISEASE; METABOLIC SYNDROME;
   CARDIOVASCULAR-DISEASE; MATERNAL-CARE; STRESS; ADOLESCENTS; HERITABILITY
AB Objective: To examine prospectively whether early parental child-rearing behavior is a predictor of cardiometabolic outcome in young adulthood when other potential risk factors are controlled. Metabolic factors associated with increased risk for cardiovascular disease have been found to vary, depending on lifestyle as well as genetic predisposition. Moreover, there is evidence suggesting that environmental conditions, such as stress in pre- and postnatal life, may have a sustained impact on an individual's metabolic risk profile. Methods: Participants were drawn from a prospective, epidemiological, cohort study followed up from birth into young adulthood. Parent interviews and behavioral observations at the age of 3 months were conducted to assess child-rearing practices and mother-infant interaction in the home setting and in the laboratory. In 279 participants, anthropometric characteristics, low-density lipoprotein and high-density lipoprotein cholesterol, apolipoproteins, and triglycerides were recorded at age 19 years. In addition, structured interviews were administered to the young adults to assess indicators of current lifestyle and education. Results: Adverse early-life interaction experiences were significantly associated with lower levels of high-density lipoprotein cholesterol and apolipoprotein A1 in young adulthood. Current lifestyle variables and level of education did not account for this effect, although habitual smoking and alcohol consumption also contributed significantly to cardiometabolic outcomes. Conclusions: These findings suggest that early parental child-rearing behavior may predict health outcome in later life through its impact on metabolic parameters in adulthood.
C1 [Kopf, Daniel; Lederbogen, Florian; Deuschle, Michael] Cent Inst Mental Hlth, Dept Psychiat & Psychotherapy, D-68159 Mannheim, Germany.
   [Buchmann, Arlette F.; Banaschewski, Tobias; Schmidt, Martin H.; Laucht, Manfred] Cent Inst Mental Hlth, Dept Child & Adolescent Psychiat & Psychotherapy, D-68159 Mannheim, Germany.
   [Westphal, Sabine] Magdeburg Univ Hosp, Inst Clin Chem & Pathobiochem, Magdeburg, Germany.
   [Esser, Guenter; Laucht, Manfred] Univ Potsdam, Div Clin Psychol, Dept Psychol, Potsdam, Germany.
   [Zimmermann, Ulrich S.] Tech Univ Dresden, Univ Hosp Carl Gustav Carus, Dept Psychiat & Psychotherapy, Dresden, Germany.
C3 Central Institute of Mental Health; Central Institute of Mental Health;
   University Hospital Magdeburg; University of Potsdam; Technische
   Universitat Dresden; Carl Gustav Carus University Hospital
RP Deuschle, M (corresponding author), Cent Inst Mental Hlth, Dept Psychiat & Psychotherapy, J 5, D-68159 Mannheim, Germany.
EM michael.deuschle@zi-mannheim.de
RI Kopf, Daniel/G-3563-2010; Zimmermann, Ulrich/B-9357-2011; Deuschle,
   Michael/E-4638-2012; Banaschewski, Tobias/ABE-5985-2020
OI Banaschewski, Tobias/0000-0003-4595-1144
FU German Research Foundation (DFG); Federal Ministry for Education and
   Research; "National Genome Research Network"
FX This study was supported by grants from the German Research Foundation
   (DFG) and the Federal Ministry for Education and Research as part of the
   "Baden-Wuerttemberg Consortium for Addiction Research" and the "National
   Genome Research Network" (A. F. B., G. E., M. H. S., U.S.Z., M. L.).
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NR 55
TC 25
Z9 28
U1 0
U2 8
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0033-3174
EI 1534-7796
J9 PSYCHOSOM MED
JI Psychosom. Med.
PD FEB-MAR
PY 2010
VL 72
IS 2
BP 156
EP 162
DI 10.1097/PSY.0b013e3181c88343
PG 7
WC Psychiatry; Psychology; Psychology, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry; Psychology
GA 559CK
UT WOS:000274797700008
PM 19995883
DA 2025-06-11
ER

PT J
AU Ringen, PA
   Lund-Stenvold, E
   Andreassen, OA
   Gaarden, TL
   Hartberg, CB
   Johnsen, E
   Myklatun, S
   Osnes, K
   Sorensen, K
   Sorensen, K
   Vaaler, A
   Tonstad, S
   Engh, JA
   Hoye, A
AF Ringen, Petter A.
   Lund-Stenvold, Elisabeth
   Andreassen, Ole A.
   Gaarden, Torfinn L.
   Hartberg, Cecilie B.
   Johnsen, Erik
   Myklatun, Silje
   Osnes, Kare
   Sorensen, Kirsten
   Sorensen, Kjetil
   Vaaler, Arne
   Tonstad, Serena
   Engh, John A.
   Hoye, Anne
TI Quality of clinical management of cardiometabolic risk factors in
   patients with severe mental illness in a specialist mental health care
   setting
SO NORDIC JOURNAL OF PSYCHIATRY
LA English
DT Article
DE Severe mental illness; schizophrenia; cardiovascular risk;
   cardiometabolic health; cardiometabolic risk; mortality risk reduction;
   health resource
ID SEDENTARY BEHAVIOR; BIPOLAR DISORDER; SUBSTANCE-ABUSE; SCHIZOPHRENIA;
   MORTALITY; ANTIPSYCHOTICS; METAANALYSIS; OBESITY; SCALE
AB Purpose Cardiometabolic disease in patients with severe mental illness is a major cause of shortened life expectancy. There is sparse evidence of real-world clinical risk prevention practice. We investigated levels of assessments of cardiometabolic risk factors and risk management interventions in patients with severe mental illness in the Norwegian mental health service according to an acknowledged international standard. Methods We collected data from 264 patients residing in six country-wide health trusts for: (a) assessments of cardiometabolic risk and (b) assessments of levels of risk reducing interventions. Logistic regressions were employed to investigate associations between risk and interventions. Results Complete assessments of all cardiometabolic risk variables were performed in 50% of the participants and 88% thereof had risk levels requiring intervention according to the standard. Smoking cessation advice was provided to 45% of daily smokers and 4% were referred to an intervention program. Obesity was identified in 62% and was associated with lifestyle interventions. Reassessment of psychotropic medication was done in 28% of the obese patients. Women with obesity were less likely to receive dietary advice, and use of clozapine or olanzapine reduced the chances for patients with obesity of getting weight reducing interventions. Conclusions Nearly nine out of the ten participants were identified as being at cardiometabolic high risk and only half of the participants were adequately screened. Women with obesity and patients using antipsychotics with higher levels of cardiometabolic side effects had fewer adequate interventions. The findings underscore the need for standardized recommendations for identification and provision of cardiometabolic risk reducing interventions in all patients with severe mental illness.
C1 [Ringen, Petter A.; Hartberg, Cecilie B.; Sorensen, Kirsten] Univ Oslo, Div Mental Hlth & Addict, Oslo Univ Hosp, Oslo, Norway.
   [Ringen, Petter A.; Andreassen, Ole A.; Hartberg, Cecilie B.; Sorensen, Kirsten] Univ Oslo, Inst Clin Med, Oslo, Norway.
   [Lund-Stenvold, Elisabeth; Hoye, Anne] UiT Arctic Univ Norway, Dept Clin Med, Tromso, Norway.
   [Lund-Stenvold, Elisabeth; Hoye, Anne] Univ Hosp North Norway, Dept Mental Hlth & Subst Abuse, Tromso, Norway.
   [Andreassen, Ole A.] Univ Oslo, NORMENT Ctr Excellence, Div Mental Hlth & Addict, Oslo Univ Hosp, Oslo, Norway.
   [Gaarden, Torfinn L.; Myklatun, Silje; Osnes, Kare] Diakonhjemmet Hosp, Div Mental Hlth & Subst Abuse, Oslo, Norway.
   [Johnsen, Erik] Univ Bergen, NORMENT Ctr Excellence, Div Psychiat, Haukeland Univ Hosp, Bergen, Norway.
   [Johnsen, Erik] Univ Bergen, Dept Clin Med, Bergen, Norway.
   [Sorensen, Kjetil] St Olavs Univ Hosp, Div Mental Hlth, Trondheim, Norway.
   [Vaaler, Arne] NTNU, Dept Acute Psychiat, St Olavs Univ Hosp, Trondheim, Norway.
   [Vaaler, Arne] NTNU, Dept Mental Hlth, Trondheim, Norway.
   [Tonstad, Serena] Oslo Univ Hosp, Sect Prevent Cardiol Endocrinol Morbid Obes & Pre, Oslo, Norway.
   [Engh, John A.] Vestfold Hosp Trust, Div Mental Hlth & Addict, Tonsberg, Norway.
C3 University of Oslo; University of Oslo; UiT The Arctic University of
   Tromso; UiT The Arctic University of Tromso; University Hospital of
   North Norway; University of Oslo; Diakonhjemmet Hospital; University of
   Bergen; Haukeland University Hospital; University of Bergen; Norwegian
   University of Science & Technology (NTNU); Norwegian University of
   Science & Technology (NTNU); Norwegian University of Science &
   Technology (NTNU); University of Oslo
RP Ringen, PA (corresponding author), Univ Oslo, Div Mental Hlth & Addict, Oslo Univ Hosp, Oslo, Norway.; Ringen, PA (corresponding author), Univ Oslo, Inst Clin Med, Oslo, Norway.
EM p.a.ringen@medisin.uio.no
RI Engh, John/AAG-6446-2021; Andreassen, Ole/AAY-7531-2020; ringen,
   petter/C-5036-2011
OI Andreassen, Ole A./0000-0002-4461-3568
FU RCN [223273, 300309]; South-East Norway Health Authority [2019-108,
   2017-112]
FX The research was supported by RCN [grant #223273, 300309] and South-East
   Norway Health Authority [grants #2019-108 and #2017-112].
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NR 39
TC 7
Z9 7
U1 1
U2 2
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0803-9488
EI 1502-4725
J9 NORD J PSYCHIAT
JI Nord. J. Psychiatr.
PD NOV 1
PY 2022
VL 76
IS 8
BP 602
EP 609
DI 10.1080/08039488.2022.2039288
EA FEB 2022
PG 8
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 5X8GP
UT WOS:000761359700001
PM 35200088
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU van de Vyver, M
   Benecke, RM
   van den Heuvel, L
   Kruger, MJ
   Powrie, Y
   Seedat, S
   Smith, C
AF van de Vyver, M.
   Benecke, R. M.
   van den Heuvel, L.
   Kruger, M. J.
   Powrie, Y.
   Seedat, S.
   Smith, C.
TI Posttraumatic stress disorder is characterized by functional
   dysregulation of dermal fibroblasts
SO BIOCHIMIE
LA English
DT Article
DE Calcium flux; Cellular dysfunction; Inflammation; Stress; Anxiety
ID METABOLIC SYNDROME; EXPRESSION; SYMPTOMS; INFLAMMATION; PREVALENCE;
   RISK; PTSD; IL-7
AB Incidence of mental health disorders are rising in modernity, with psychological stress linked to a propensity for developing various chronic diseases due to a relative inability of the body to counter the allostatic load on cellular level. Despite these high rates of comorbidities associated with posttraumatic stress disorder (PTSD), there is still a lack of understanding in terms of the peripheral effects of PTSD on tissue level. Therefore, the purpose of this study was to profile basal dermal fibroblast functional status in PTSD using a wide range of markers involved in the cell-to-cell communication facilitated by fibroblasts. Primary dermal fibroblasts derived from patients diagnosed with PTSD (n = 11) and matched trauma exposed controls (i.e. who did not develop PTSD, n = 10) were cultured using standard techniques. The patients and controls were matched based on age, sex, body-mass index (BMI) and lifestyle. The growth rate, population doubling time, cell surface marker expression (CD31, FNDC5) (flow cytometry), secretome (TIMP-2, MMP-9) (ELISAs), intracellular signalling capacity (Fluo-4 Ca2 2 flux) and gene expression (IL-6, IL-10, PTX-3, iNOS, Arg1) were compared between groups. The data illustrated significant PTSDassociated fibroblast conditioning resulting in a blunted signalling capacity. This observation highlights the importance of including tissue-specific investigations in future studies focused on elucidating the association between PTSD and subsequent risk for somatic disease. (c) 2024 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
C1 [van de Vyver, M.; Kruger, M. J.; Powrie, Y.; Smith, C.] Stellenbosch Univ, Fac Med & Hlth Sci, Dept Med, Expt Med Res Grp,Div Internal Med, Francie van Zijl Dr, ZA-7505 Parow, South Africa.
   [Benecke, R. M.] Stellenbosch Univ, Fac Med & Hlth Sci, Dept Med, Div Clin Pharmacol, Stellenbosch, South Africa.
   [van den Heuvel, L.; Seedat, S.] Univ Stellenbosch, Fac Med & Hlth Sci, Dept Psychiat, Francie van Zijl Dr, ZA-7505 Cape Town, South Africa.
   [van den Heuvel, L.; Seedat, S.] Stellenbosch Univ, Genom Brain Disorders Res Unit, Fac Med & Hlth Sci, South African Med Res Council,Dept Psychiat, Cape Town, South Africa.
C3 Stellenbosch University; Stellenbosch University; Stellenbosch
   University; South African Medical Research Council
RP Smith, C (corresponding author), Stellenbosch Univ, Fac Med & Hlth Sci, Dept Med, Expt Med Res Grp,Div Internal Med, Francie van Zijl Dr, ZA-7505 Parow, South Africa.
EM csmith@sun.ac.za
RI M, van/H-3433-2019; van den Heuvel, Lotte/GLR-5530-2022; Powrie,
   Yigael/CAG-1220-2022; Powrie, Yigael/R-1094-2018; Smith,
   Carine/D-7159-2012
OI van de Vyver, Mari/0000-0002-0861-2939; Powrie,
   Yigael/0000-0001-8044-9390; Benecke, Rohan/0000-0002-8854-0380; Smith,
   Carine/0000-0001-5924-9204
FU South African Medical Research Council from the South African National
   Treasury [MRC-RFA-IFSP-01-2013]; National Research Foundation of South
   Africa [138430]; South African Medical Research Council
FX Research reported in this publication was supported by the South African
   Medical Research Council for the "Shared Roots" Flagship Project, Grant
   no. MRC-RFA-IFSP-01-2013/SHARED ROOTS" through funding received from the
   South African National Treasury under its Economic Competitiveness and
   Support Package. Its contents are solely the responsibility of the
   authors and do not necessarily represent the official views of the South
   African Medical Research Council. The work by Leigh van den Heuvel was
   supported in part by the National Research Foundation of South Africa
   (Grant Number 138430) and by the South African Medical Research Council
   under a Self-Initiated Research Grant. The content hereof is the sole
   responsibility of the authors and do not necessarily represent the
   official views of the SAMRC or the funders. Professors Robert Fenn and
   Jean Millar are acknowledged for salary funding. Funders have played no
   role in the study design, data collection, analysis, and interpretation
   and in writing the manuscript.
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NR 53
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0300-9084
EI 1638-6183
J9 BIOCHIMIE
JI Biochimie
PD OCT
PY 2024
VL 225
BP 10
EP 18
DI 10.1016/j.biochi.2024.05.006
EA MAY 2024
PG 9
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA J7X9W
UT WOS:001339165900001
PM 38719136
OA hybrid
DA 2025-06-11
ER

PT J
AU Toker, S
   Shirom, A
   Melamed, S
AF Toker, Sharon
   Shirom, Arie
   Melamed, Samuel
TI Depression and the metabolic syndrome: Gender-dependent associations
SO DEPRESSION AND ANXIETY
LA English
DT Article
DE depression; metabolic syndrome; cardiovascular diseases
ID CORONARY-HEART-DISEASE; CARDIOVASCULAR-DISEASE; YOUNG-ADULTS; RISK;
   SYMPTOMS; ANXIETY; HEALTHY; PREVALENCE; MORTALITY; ATHEROSCLEROSIS
AB This study was designed to test the extent to which depressive symptoms are associated with the presence of the metabolic syndrome (MS) and each of its components, and whether these relationships are gender dependent. Participants were apparently healthy employed men (N = 2,355) and women (N = 1,525) who underwent a routine health check between the years 2003 and 2005. We used logistic regression analysis, predicting the MS by depressive symptoms, as assessed by the Patient Health Questionnaire, and the following control variables: age, education, smoking status, physical exercise, anxiety, and burnout. As hypothesized, we found that depression among women, but not men, was associated with a 1.94-fold risk of having the MS, and with an elevated risk of having two of its five components: elevated waist circumference (odds ratio, OR = 2.23) and elevated glucose levels (OR = 2.44). In addition, a positive trend was observed toward an association with the other three components: low high-density lipoprotein, hypertension, and elevated triglycerides. Among men depression was associated with elevated waist circumference only (OR = 1. 77). These findings suggest that especially among women, the association between depression and cardiovascular diseases might be linked to metabolic processes. If replicated in longitudinal studies, these findings may have important health-care policy implications with regard to depression management interventions.
C1 [Toker, Sharon; Shirom, Arie] Tel Aviv Univ, Fac Management, IL-69978 Tel Aviv, Israel.
   [Melamed, Samuel] Tel Aviv Univ, Sackler Sch Med, Dept Epidemiol & Prevent Med, IL-69978 Tel Aviv, Israel.
C3 Tel Aviv University; Tel Aviv University; Sackler Faculty of Medicine
RP Toker, S (corresponding author), Tel Aviv Univ, Fac Management, POB 39010, IL-69978 Tel Aviv, Israel.
EM sharon.toker@gmail.com
RI Toker, Sharon/P-5428-2015
OI Toker, Sharon/0000-0001-7621-6607
FU Israel National Institute for Health Policy and Health Services
   Research; Israel Science Foundation [962/02 - 1]
FX The first author acknowledge with thanks a doctoral dissertation grant
   supporting this study, received from the Israel National Institute for
   Health Policy and Health Services Research. We also acknowledge with
   thanks the financial support provided to the study by the Israel Science
   Foundation (Grant 962/02 - 1).
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NR 60
TC 72
Z9 78
U1 1
U2 22
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1091-4269
EI 1520-6394
J9 DEPRESS ANXIETY
JI Depress. Anxiety
PY 2008
VL 25
IS 8
BP 661
EP 669
DI 10.1002/da.20379
PG 9
WC Psychology, Clinical; Psychiatry; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA 344BS
UT WOS:000258900900003
PM 17941099
OA gold
DA 2025-06-11
ER

PT J
AU Kang, SW
   Yoo, JS
AF Kang, Se Won
   Yoo, Ji Soo
TI Health-promoting lifestyle and depression in metabolic syndrome patients
   in Korea
SO INTERNATIONAL JOURNAL OF NURSING PRACTICE
LA English
DT Article
DE depression; intervention; lifestyle; metabolic syndrome; nursing
   assessment
ID MIDDLE-AGED MEN; SYMPTOMS; OLDER; REDUCTION; ADHERENCE; BEHAVIORS;
   MORTALITY; PATTERNS; TAIWAN; IMPACT
AB Kang SW, Yoo JS. International Journal of Nursing Practice 2012; 18: 268274 Health-promoting lifestyle and depression in metabolic syndrome patients in Korea This cross-sectional study assessed the association between health-promoting lifestyle and depression in metabolic syndrome patients by using a questionnaire survey in Korea. Data were collected from 195 adults (> 20 years old) with hypertension, dyslipidemia and diabetes. The correlation coefficient (r) between health-promoting lifestyle and depression was -0.309 (P < 0.001), and correlation between individual lifestyle dimensions and depression varied from -0.135 to -0.391. The non-depressed group had higher health-promoting lifestyle scores than the depressed group (P = 0.003). Scores for three dimensions of the health-promoting lifestyle profileself-actualization (P < 0.001), interpersonal support (P = 0.001) and stress management (P = 0.025)were significantly higher in the non-depressed groups. Logistic regression analysis provided an odds ratio of 2.766 (P = 0.003) for health-promoting lifestyle between the two groups. For patients with metabolic syndrome, depression was negatively associated with health-promoting lifestyle and is an important factor affecting health-promoting behaviour.
C1 [Kang, Se Won] Dong Eui Univ, Coll Nursing & Hlth Sci, Pusan 614714, South Korea.
   [Yoo, Ji Soo] Yonsei Univ, Nursing Policy Res Inst, Coll Nursing, Seoul 120749, South Korea.
C3 Dong-Eui University; Yonsei University; Yonsei University Health System
RP Kang, SW (corresponding author), Dong Eui Univ, Coll Nursing & Hlth Sci, 995 Eomgwangno, Pusan 614714, South Korea.
EM swkang75@hotmail.com
RI Kang, sewon/KHX-8924-2024
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NR 30
TC 17
Z9 22
U1 1
U2 19
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1322-7114
J9 INT J NURS PRACT
JI Int. J. Nurs. Pract.
PD JUN
PY 2012
VL 18
IS 3
BP 268
EP 274
DI 10.1111/j.1440-172X.2012.02036.x
PG 7
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA 946ZH
UT WOS:000304395900008
PM 22621297
DA 2025-06-11
ER

PT J
AU Bijnens, EM
   Derom, C
   Thiery, E
   Martens, DS
   Loos, RJF
   Weyers, S
   Nawrot, TS
AF Bijnens, Esmee M.
   Derom, Catherine
   Thiery, Evert
   Martens, Dries S.
   Loos, Ruth J. F.
   Weyers, Steven
   Nawrot, Tim S.
TI Serum gamma-glutamyl transferase, a marker of alcohol intake, is
   associated with telomere length and cardiometabolic risk in young
   adulthood
SO SCIENTIFIC REPORTS
LA English
DT Article
ID CIGARETTE-SMOKING; OXIDATIVE STRESS; METABOLIC SYNDROME; LIFE;
   GLUTAMYLTRANSFERASE; METAANALYSIS; CONSUMPTION; POPULATION; EXPOSURE;
   DIETARY
AB Studies based on self-reported alcohol consumption and telomere length show inconsistent results. Therefore, we studied the association between gamma-glutamyl transferase (GGT), a widely used biomarker of alcohol intake, and telomere length. The possible health relevance in young adulthood was explored by investigating cardiometabolic risk factors. Mixed modelling was performed to examine GGT and alcohol consumption in association with telomere length in buccal cells of 211 adults between 18 and 30 years old of the East Flanders Prospective Twin Survey. In addition, we investigated the association between GGT and cardiometabolic risk factors; waist circumference, systolic blood pressure, fasting glucose, HDL cholesterol, and triglycerides. Although we did not observe an association between self-reported alcohol consumption and telomere length, our results show that a doubling in serum GGT is associated with 7.80% (95% CI - 13.9 to - 1.2%; p=0.02) shorter buccal telomeres, independently from sex, chronological age, educational level, zygosity and chorionicity, waist-to-hip ratio and smoking. The association between GGT was significant for all five cardiometabolic risk factors, while adjusting for age. We show that GGT, a widely used biomarker of alcohol consumption, is associated with telomere length and with risk factors of cardiometabolic syndrome, despite the young age of this study population.
C1 [Bijnens, Esmee M.; Martens, Dries S.; Nawrot, Tim S.] Hasselt Univ, Ctr Environm Sci, Agoralaan Bldg D, B-3590 Diepenbeek, Belgium.
   [Bijnens, Esmee M.; Derom, Catherine; Weyers, Steven] Ghent Univ Hosp, Dept Human Struct & Repair, Corneel Heymanslaan 10, B-9000 Ghent, Belgium.
   [Derom, Catherine] Univ Hosp Leuven, Ctr Human Genet, Herestr 49, B-3000 Leuven, Belgium.
   [Thiery, Evert] Ghent Univ Hosp, Dept Neurol, Corneel Heymanslaan 10, B-9000 Ghent, Belgium.
   [Loos, Ruth J. F.] Icahn Sch Med Mt Sinai, Charles Bronfman Inst Personalized Med, Mindich Child Hlth & Dev Inst, Genet Obes & Related Metab Traits Program, 1468 Madison Ave, New York, NY 10029 USA.
   [Nawrot, Tim S.] Leuven Univ KU Leuven, Dept Publ Hlth, Kapucijnenvoer 35, B-3000 Leuven, Belgium.
C3 Hasselt University; Ghent University; Ghent University Hospital; KU
   Leuven; University Hospital Leuven; Ghent University; Ghent University
   Hospital; Icahn School of Medicine at Mount Sinai; KU Leuven
RP Bijnens, EM (corresponding author), Hasselt Univ, Ctr Environm Sci, Agoralaan Bldg D, B-3590 Diepenbeek, Belgium.; Bijnens, EM (corresponding author), Ghent Univ Hosp, Dept Human Struct & Repair, Corneel Heymanslaan 10, B-9000 Ghent, Belgium.
EM esmee.bijnens@uhasselt.be
RI Derom, Catherine/HLH-2625-2023; Loos, Ruth/AFU-8669-2022; Odili,
   Augustine/O-2612-2019; Loos, Ruth/Q-2862-2016
OI Nawrot, Tim/0000-0002-3583-3593; Loos, Ruth/0000-0002-8532-5087;
   Bijnens, Esmee/0000-0001-8537-843X; Derom, Catherine/0000-0001-5574-796X
FU EU research council [ERC-2012-StG 310890]; Flemish Scientific Fund (FWO)
   [G073315N, 12X9620N]; Marguerite-Marie Delacroix foundation; Fund of
   Scientific Research Flanders and Twins, a non-profit Association for
   Scientific Research in Multiple Births (Belgium)
FX This investigation is supported by the EU research council "project
   ENVIRONAGE" (ERC-2012-StG 310890), and the Flemish Scientific Fund (FWO,
   G073315N). Dr. Bijnens holds a fellow-ship from the Marguerite-Marie
   Delacroix foundation. Dr. Martens is a postdoctoral fellow of the FWO
   (12X9620N). Since its start, the East Flanders Prospective Twin Survey
   has been partly supported by grants from the Fund of Scientific Research
   Flanders and Twins, a non-profit Association for Scientific Research in
   Multiple Births (Belgium).
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NR 49
TC 7
Z9 8
U1 0
U2 7
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD JUN 11
PY 2021
VL 11
IS 1
AR 12407
DI 10.1038/s41598-021-91987-6
PG 8
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA SV4GJ
UT WOS:000663778500028
PM 34117333
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Cheng, S
   Lyass, A
   Massaro, JM
   O'Connor, GT
   Keaney, JF
   Vasan, RS
AF Cheng, Susan
   Lyass, Asya
   Massaro, Joseph M.
   O'Connor, George T.
   Keaney, John F., Jr.
   Vasan, Ramachandran S.
TI Exhaled Carbon Monoxide and Risk of Metabolic Syndrome and
   Cardiovascular Disease in the Community
SO CIRCULATION
LA English
DT Article
DE cardiovascular diseases; carbon monoxide; epidemiology; metabolic
   syndrome; risk factors
ID HEME OXYGENASE; OXIDATIVE STRESS; BILIRUBIN; BLOOD; EXPRESSION;
   EXPOSURE; AIR; AGE; ASSOCIATION; POPULATION
AB Background-Endogenous carbon monoxide (CO) at physiological concentrations is cytoprotective, whereas excess levels reflect underlying oxidative stress, inflammation, and vascular pathology and portend adverse clinical sequelae. However, the relation of exhaled CO to metabolic/vascular risk in the community is unknown.
   Methods and Results-We related exhaled CO, a surrogate measure of blood CO concentration, to the risk of developing new-onset metabolic syndrome and incident cardiovascular disease following 14 943 routine examinations (4139 unique participants; mean age, 46 years, 53% women) in the Framingham Heart Study. Baseline exhaled CO was associated with the presence of cardiometabolic risk factors (including smoking) and prevalent metabolic syndrome (odds ratio, 1.09 per log CO; 95% confidence interval, 1.02 to 1.17; P=0.01). During up to 4 years of follow-up, 1458 participants developed new-onset metabolic syndrome, and 416 experienced a first cardiovascular disease event. Compared with individuals in the lowest quartile of exhaled CO, those in the highest quartile were more likely to develop metabolic syndrome (odds ratio, 1.48; 95% confidence interval, 1.25 to 1.76; P<0.0001) and cardiovascular disease events (hazard ratio, 1.66; 95% confidence interval, 1.14 to 2.40; P=0.008) in multivariable analyses that included adjustment for smoking status.
   Conclusion-In our community-based sample, higher exhaled CO levels predicted the development of metabolic syndrome and future cardiovascular disease events, underscoring the importance of this endogenous second messenger in the pathogenesis of metabolic and vascular risk. (Circulation. 2010;122:1470-1477.)
C1 [Cheng, Susan; Lyass, Asya; O'Connor, George T.; Vasan, Ramachandran S.] Framingham Heart Dis Epidemiol Study, Framingham, MA 01702 USA.
   [Cheng, Susan] Brigham & Womens Hosp, Dept Med, Div Cardiovasc Med, Boston, MA 02115 USA.
   [Cheng, Susan] Beth Israel Deaconess Med Ctr, Clin Investigator Training Program, Boston, MA 02215 USA.
   [Lyass, Asya] Boston Univ, Dept Math & Stat, Boston, MA 02215 USA.
   [Massaro, Joseph M.] Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA USA.
   [O'Connor, George T.] Boston Univ, Sch Med, Ctr Pulm, Boston, MA 02118 USA.
   [Vasan, Ramachandran S.] Boston Univ, Sch Med, Prevent Med & Epidemiol Sect, Dept Med, Boston, MA 02118 USA.
   [Keaney, John F., Jr.] Univ Massachusetts, Sch Med, Dept Med, Boston, MA 02125 USA.
C3 Framingham Heart Study; Harvard University; Harvard University Medical
   Affiliates; Brigham & Women's Hospital; Harvard University; Harvard
   University Medical Affiliates; Beth Israel Deaconess Medical Center;
   Boston University; Boston University; Boston University; Boston
   University; University of Massachusetts System; University of
   Massachusetts Boston
RP Vasan, RS (corresponding author), Framingham Heart Dis Epidemiol Study, 73 Mt Wayte Ave,Ste 2, Framingham, MA 01702 USA.
EM vasan@bu.edu
RI Cheng, Chi-An/AAD-7706-2022; Ramachandran, Vasan/Y-2527-2019
OI Cheng, Susan/0000-0002-4977-036X; Ramachandran,
   Vasan/0000-0001-7357-5970; O'Connor, George/0000-0002-6476-3926; Keaney,
   John/0000-0002-0866-1837; Massaro, Joseph/0000-0002-2682-4812
FU National Heart, Lung and Blood Institute's Framingham Heart Study
   [NO1-HC-25195]; American College of Cardiology Foundation/Merck Research
   Fellowship
FX This work was supported in part by the National Heart, Lung and Blood
   Institute's Framingham Heart Study (contract No. NO1-HC-25195) and the
   American College of Cardiology Foundation/Merck Research Fellowship in
   Cardiovascular Disease and Cardiometabolic Disorders (Dr Cheng).
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NR 41
TC 40
Z9 41
U1 1
U2 8
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0009-7322
EI 1524-4539
J9 CIRCULATION
JI Circulation
PD OCT 12
PY 2010
VL 122
IS 15
BP 1470
EP 1477
DI 10.1161/CIRCULATIONAHA.110.941013
PG 8
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 661SS
UT WOS:000282749000010
PM 20876437
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Lien, HC
   Chiang, KJ
   Feng, HP
   Lin, CH
   Chang, YC
   Tzeng, WC
AF Lien, Hsien-Chih
   Chiang, Kai-Jo
   Feng, Hsin-Pei
   Lin, Chia-Huei
   Chang, Yue-Cune
   Tzeng, Wen-Chii
TI Mental Health Nurses' Knowledge of Metabolic Syndrome: A Cross-Sectional
   Study
SO NURSING FORUM
LA English
DT Article
ID CARE
AB Background: Adequate knowledge of the metabolic syndrome is essential for mental health nurses as it enhances their ability to recognize and address the physical needs of individuals diagnosed with serious mental illnesses.Aims: This study investigated the factors influencing the level of metabolic syndrome knowledge among mental health nurses.Methods: A cross-sectional study was conducted with 208 mental health nurses recruited from four hospitals in northern Taiwan, including two regional hospitals, one medical center, and one mental health hospital. Nurses' knowledge was assessed using a validated 20-item self-administered questionnaire covering key aspects of metabolic syndrome, including pathophysiology, diagnostic criteria, and management. The questionnaire demonstrated satisfactory reliability (KR-20 = 0.702) and content validity. Data analysis involved descriptive statistics, independent t-tests, one-way analysis of variance, Pearson correlation coefficient, and generalized linear models to identify predictors of knowledge levels.Results: The overall correct answer rate was 60.1%. Generalized linear modeling demonstrated that nurses' knowledge was significantly associated with their sources of information (B = 1.371, 95% CI = 0.458-2.285, p = 0.003), the type of hospital they worked in (B = -1.027, 95% CI = -2.015 to -0.039, p = 0.042), and working in a community unit (B = 1.975, 95% CI = 0.067-3.883, p = 0.042).Conclusions: Our results indicate that mental health nurses possessed a moderate level of knowledge concerning metabolic syndrome in people diagnosed with serious mental illness. Addressing this gap requires targeted education programs that integrate physical health education into psychiatric care and promote the use of diverse, evidence-based resources tailored to the specific needs of mental health nurses in different settings. Organizational efforts should focus on fostering a supportive culture that enhances access to high-quality resources, encourages interdisciplinary collaboration, and supports continuous professional development.
C1 [Lien, Hsien-Chih; Chiang, Kai-Jo; Tzeng, Wen-Chii] Tri Serv Gen Hosp, Dept Nursing, Taipei City 114202, Taiwan.
   [Feng, Hsin-Pei; Lin, Chia-Huei] Natl Def Med Ctr, Sch Nursing, Taipei City 114201, Taiwan.
   [Chang, Yue-Cune] Tamkang Univ, Dept Math, New Taipei City 251301, Taiwan.
C3 Tri-Service General Hospital; National Defense Medical Center; Tamkang
   University
RP Tzeng, WC (corresponding author), Tri Serv Gen Hosp, Dept Nursing, Taipei City 114202, Taiwan.
EM wctzeng@mail.ndmctsgh.edu.tw
RI Lin, Chia-Huei/GLQ-5499-2022; Tzeng, Wen-Chii/M-4214-2014
OI Chang, Yue-Cune/0000-0002-0224-1268; Tzeng,
   Wen-Chii/0000-0002-4205-896X; Lin, Chia-Huei/0000-0003-3751-602X
FU Tri-Service General Hospital
FX The authors deeply thank all participants who were involved in this
   study. We confirm that no artificial intelligence tools were used in the
   preparation of this manuscript, including planning, analysis, table and
   figure generation, or drafting. All content is the result of the
   authors' intellectual efforts.
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NR 35
TC 0
Z9 0
U1 1
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0029-6473
EI 1744-6198
J9 NURS FORUM
JI Nurs. Forum
PD DEC 20
PY 2024
VL 2024
AR 2808471
DI 10.1155/nuf/2808471
PG 12
WC Nursing
WE Emerging Sources Citation Index (ESCI)
SC Nursing
GA R2G5L
UT WOS:001389699900001
OA hybrid
DA 2025-06-11
ER

PT J
AU Lee, SY
   Lee, JP
   Lee, JH
   Park, JY
   Kim, EY
AF Lee, Seo-yoon
   Lee, Jung Pyo
   Lee, Jeonghwan
   Park, Jae Yoon
   Kim, Eun Young
TI Association between depressive symptoms and the risk of all-cause and
   cardiovascular mortality among US adults
SO PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
LA English
DT Article
DE Depression; All-cause mortality; Cardiovascular mortality; Sex
   difference; Age difference
ID NATIONAL EPIDEMIOLOGIC SURVEY; METABOLIC SYNDROME; EXCESS MORTALITY;
   MAJOR DEPRESSION; DISEASE; DISORDER; METAANALYSIS; PREVALENCE; ANXIETY;
   HEART
AB Depression is a preventable and treatable mental health condition. Therefore, there are important clinical implications for identifying people with the highest mortality risk in a nationally representative sample. This study included 26,207 participants aged >= 18 years from the 2005-2014 National Health and Nutrition Examination Survey in USA. We investigated the association between depressive symptoms (defined as Patient Health Questionnaire 9 scores >= 10) and all-cause and cardiovascular disease (CVD) mortalities, adjusted for multiple factors (sociodemographic in Model 1, behavioral added in Model 2, and metabolic syndrome added in Model 3) and stratified by age and sex. During an average follow-up of 69.15 months (standard deviation [SD] 34.45), 1872 (7.3%) participants had died (person-years in the non-depressive and depressive groups, 12.12/1000 and 16.43/1000, respectively). Depressive symptoms increased all-cause (crude hazard ratio [HR] 1.37, 95% confidence interval [CI], 1.33-1.58) and CVD mortalities (crude HR 1.64, 95% CI, 1.20-2.24). Although the significance of all-cause mortality and CVD mortality was maintained in Models 1 (HR 1.58 and 2.08) and 2 (HR 1.48 and 1.79), it was not maintained in Model 3. Current smoking and lower physical activity were associated with reduced strength of the association between depression and all-cause mortality risk. The effect of depression on mortality risk was particularly pronounced in middle-aged men and older women. Our findings suggest that depressive symptoms increase mortality risk, even after adjusting for behavioral factors. Depression-induced mortality risk is particularly high among middle-aged men and older women.
C1 [Lee, Seo-yoon] Natl Canc Ctr, Dept Psychiat, 323 Ilsan ro, Goyang Si 10408, Gyeonggi Do, South Korea.
   [Lee, Seo-yoon] Korea Univ, Dept Psychol, 145 Anam ro, Seoul 02841, South Korea.
   [Lee, Jung Pyo; Lee, Jeonghwan] Seoul Natl Univ, Coll Med, Dept Internal Med, Seoul, South Korea.
   [Lee, Jung Pyo; Lee, Jeonghwan] Seoul Natl Univ, Boramae Med Ctr, Dept Internal Med, Seoul, South Korea.
   [Park, Jae Yoon] Dongguk Univ, Ilsan Hosp, Dept Internal Med, Goyang, South Korea.
   [Park, Jae Yoon] Dongguk Univ, Coll Med, Dept Internal Med, Gyeongju, South Korea.
   [Kim, Eun Young] Seoul Natl Univ, Coll Med, Dept Human Syst Med, 101 Daehak ro, Seoul 03080, South Korea.
   [Kim, Eun Young] Seoul Natl Univ, Hlth Care Ctr, Mental Hlth Ctr, 1 Gwanak ro, Seoul 08826, South Korea.
   [Kim, Eun Young] Seoul Natl Univ, Hlth Care Ctr, Mental Hlth Ctr, Dept Psychiat, 63 444 1 Gwanak ro, Seoul 08826, South Korea.
C3 National Cancer Center - Korea (NCC); Korea University; Seoul National
   University (SNU); Seoul National University (SNU); Seoul National
   University Hospital; Dongguk University; NHIS Ilsan Hospital; Dongguk
   University; Seoul National University (SNU); Seoul National University
   (SNU); Seoul National University (SNU)
RP Kim, EY (corresponding author), Seoul Natl Univ, Hlth Care Ctr, Mental Hlth Ctr, Dept Psychiat, 63 444 1 Gwanak ro, Seoul 08826, South Korea.
EM ey00@snu.ac.kr
RI Kim, YoungHwan/B-2395-2013; Lee, Jeonghwan/C-5214-2011; Lee,
   Joo/C-3851-2013
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NR 54
TC 21
Z9 21
U1 0
U2 1
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0278-5846
EI 1878-4216
J9 PROG NEURO-PSYCHOPH
JI Prog. Neuro-Psychopharmacol. Biol. Psychiatry
PD JUL 13
PY 2023
VL 125
AR 110755
DI 10.1016/j.pnpbp.2023.110755
EA APR 2023
PG 9
WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA G7GH0
UT WOS:000990794000001
PM 36958666
DA 2025-06-11
ER

PT J
AU Ali, NH
   Al-Kuraishy, HM
   Al-Gareeb, AI
   Alexiou, A
   Papadakis, M
   Bahaa, MM
   Alibrahim, F
   Batiha, GE
AF Ali, Naif H.
   Al-Kuraishy, Hayder M.
   Al-Gareeb, Ali I.
   Alexiou, Athanasios
   Papadakis, Marios
   Bahaa, Mostafa M.
   Alibrahim, Fawaz
   Batiha, Gaber El-Saber
TI New insight on the potential detrimental effect of metabolic syndrome on
   the Alzheimer disease neuropathology: Mechanistic role
SO JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
LA English
DT Review
DE Alzheimer disease; metabolic syndrome; neuroinflammation
ID HYDROGEN-SULFIDE PROTECTS; BRAIN INSULIN-RESISTANCE;
   HIGH-DENSITY-LIPOPROTEIN; AMYLOID-BETA; OXIDATIVE STRESS; CEREBRAL
   HYPOPERFUSION; COGNITIVE FUNCTION; MOUSE MODEL; RISK; ASSOCIATION
AB The metabolic syndrome or syndrome X is a clustering of different components counting insulin resistance (IR), glucose intolerance, visceral obesity, hypertension and dyslipidemia. It has been shown that IR and dysregulation of insulin signalling play a critical role in the development of metabolic syndrome by initiating the pathophysiology of metabolic syndrome through induction of glucolipotoxicity, impairment of glucose disposal and triggering of pro-inflammatory response. Furthermore, metabolic syndrome unfavourably affects the cognitive function and the development of different neurodegenerative diseases such as Alzheimer disease (AD) by inducing oxidative stress, neuroinflammation and brain IR. These changes together with brain IR impair cerebrovascular reactivity leading to cognitive impairment. In addition, metabolic syndrome increases the risk for the development of AD. However, the central mechanisms by which metabolic syndrome amplify AD risk are not completely elucidated. Consequently, this narrative review aims to revise from published articles the association between metabolic syndrome and AD regarding cellular and subcellular pathways. In conclusion, metabolic syndrome is regarded as a potential risk factor for the induction of AD neuropathology by different signalling pathways such as initiation of brain IR, activation of inflammatory signalling pathways and neuroinflammation.
C1 [Ali, Naif H.] Najran Univ, Dept Internal Med, Med Coll, Najran, Saudi Arabia.
   [Al-Kuraishy, Hayder M.] Mustansiriyah Univ, Coll Med, Dept Clin Pharmacol & Med, Baghdad, Iraq.
   [Al-Gareeb, Ali I.] Jabir Ibn Hayyan Med Univ, Najaf, Iraq.
   [Alexiou, Athanasios] Novel Global Community Educ Fdn, Dept Sci & Engn, Hebersham, NSW, Australia.
   [Alexiou, Athanasios] AFNP Med, Dept Res & Dev, Vienna, Austria.
   [Alexiou, Athanasios] Funogen, Dept Res & Dev, Athens 11741, Greece.
   [Alexiou, Athanasios] Chandigarh Univ, Univ Ctr Res & Dev, Mohali, Punjab, India.
   [Papadakis, Marios] Univ Witten Herdecke, Univ Hosp Witten Herdecke, Dept Surg 2, Heusnerstr 40, D-42283 Wuppertal, Germany.
   [Bahaa, Mostafa M.] Horus Univ, Fac Pharm, Pharm Practice Dept, New Damietta, Egypt.
   [Alibrahim, Fawaz] Minist Natl Guard Hlth Affairs, Div Neurol, King Abdulaziz Med City, Riyadh, Saudi Arabia.
   [Batiha, Gaber El-Saber] Damanhour Univ, Fac Vet Med, Dept Pharmacol & Therapeut, Damanhour, Egypt.
C3 Najran University; Mustansiriya University; Jabir Ibn Hayyan University
   for Medical & Pharmaceutical Sciences; Chandigarh University; Witten
   Herdecke University; King Saud Bin Abdulaziz University for Health
   Sciences; Ministry of National Guard - Health Affairs; Egyptian
   Knowledge Bank (EKB); Damanhour University
RP Papadakis, M (corresponding author), Univ Witten Herdecke, Univ Hosp Witten Herdecke, Dept Surg 2, Heusnerstr 40, D-42283 Wuppertal, Germany.
EM drmariospapadakis@gmail.com
RI Papadakis, Marios/AAI-6622-2020; Al-gareeb, Ali/AHD-4577-2022;
   al-kuraishy, hayder/AAE-6673-2019; Alexiou, Athanasios/AAT-8491-2021
OI Alexiou, Athanasios/0000-0002-2206-7236; Papadakis,
   Marios/0000-0002-9020-874X
FU University of Written-Herdeck, Germany.
FX University of Written-Herdeck, Germany.
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NR 120
TC 5
Z9 5
U1 4
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1582-1838
EI 1582-4934
J9 J CELL MOL MED
JI J. Cell. Mol. Med.
PD DEC
PY 2024
VL 28
IS 23
AR e70118
DI 10.1111/jcmm.70118
PG 13
WC Cell Biology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Research & Experimental Medicine
GA O5A3O
UT WOS:001371248600001
PM 39644152
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Bojar, I
   Raczkiewicz, D
   Sarecka-Hujar, B
AF Bojar, Iwona
   Raczkiewicz, Dorota
   Sarecka-Hujar, Beata
TI Depression, Metabolic Syndrome, Serum TSH, and Vitamin D Concentrations
   in Rural and Urban Postmenopausal Women
SO MEDICINA-LITHUANIA
LA English
DT Article
DE depression; TSH; metabolic syndrome; vitamin D; post menopause
ID D SUPPLEMENTATION; D-RECEPTOR; SYMPTOMS; ANXIETY; METAANALYSIS;
   PREVALENCE; DISORDER; OBESITY
AB Background and objectives: Depression is a serious problem affecting people worldwide, however it more commonly concerns women. Depression reduces the quality of life and, in many cases, leads to suicide. Numerous new biological factors have been demonstrated to have an impact on the pathogenesis of depression, including vitamin D, thyroid hormones, as well as factors related to heart disease. The aim of the study was to assess the impact of serum thyroid stimulating hormone (TSH) and vitamin D concentrations as well as metabolic syndrome on the severity of depression in Polish postmenopausal women from urban and rural areas. Materials and Methods: The study was conducted in 2018-2019 in the Lublin region, Poland, and comprised 396 postmenopausal women (239 living in rural areas and 157 living in urban areas). Metabolic syndrome criteria according to the International Diabetes Federation and Beck Depression Inventory were used, and laboratory blood tests were performed. Results: A significantly higher percentage of the examined rural residents had moderate or severe depression in comparison to the urban ones (p = 0.049). The examined women from rural areas had a significantly higher serum vitamin D concentration in comparison to the urban ones (p < 0.001). The rural residents more commonly had below-normal levels of serum TSH and less commonly had normal levels in comparison to the urban residents. Metabolic syndrome was found in 70% of the rural residents, and that number was significantly lower in the urban ones (22%, p < 0.001). Conclusions: The severity of depression in postmenopausal Polish women was correlated negatively with the serum TSH concentration in women from rural areas. The severity of depression was increased in urban postmenopausal women with hypertension. No correlation of the depression severity with the serum vitamin D concentration or other criteria of metabolic syndrome was found.
C1 [Bojar, Iwona] Inst Rural Hlth, Dept Womens Hlth, PL-20950 Lublin, Poland.
   [Raczkiewicz, Dorota] SGH Warsaw Sch Econ, Coll Econ Anal, Inst Stat & Demog, PL-02554 Warsaw, Poland.
   [Sarecka-Hujar, Beata] Med Univ Silesia, Fac Pharmaceut Sci Sosnowiec, Dept Basic Biomed Sci, PL-41200 Sosnowiec, Poland.
C3 Institute of Rural Health in Lublin, Poland; Warsaw School of Economics;
   Medical University of Silesia
RP Sarecka-Hujar, B (corresponding author), Med Univ Silesia, Fac Pharmaceut Sci Sosnowiec, Dept Basic Biomed Sci, PL-41200 Sosnowiec, Poland.
EM iwonabojar75@gmail.com; dorota.bartosinska@gmail.com;
   beatasarecka@poczta.onet.pl
RI Raczkiewicz, Dorota/HKV-8966-2023; Bojar, Iwona/S-6029-2018
OI Bojar, Iwona/0000-0002-3171-225X; Raczkiewicz,
   Dorota/0000-0003-3517-6711; Sarecka-Hujar, Beata/0000-0003-0002-8591
CR Anglin RES, 2013, BRIT J PSYCHIAT, V202, P100, DOI 10.1192/bjp.bp.111.106666
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NR 44
TC 6
Z9 6
U1 0
U2 5
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1010-660X
EI 1648-9144
J9 MEDICINA-LITHUANIA
JI Med. Lith.
PD OCT
PY 2020
VL 56
IS 10
AR 511
DI 10.3390/medicina56100511
PG 11
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA ON7SU
UT WOS:000586896500001
PM 33008063
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Jood, K
   Redfors, P
   Rosengren, A
   Blomstrand, C
   Jern, C
AF Jood, Katarina
   Redfors, Petra
   Rosengren, Annika
   Blomstrand, Christian
   Jern, Christina
TI Self-perceived psychological stress and ischemic stroke: a case-control
   study
SO BMC MEDICINE
LA English
DT Article
ID MIDDLE-AGED MEN; CORONARY-ARTERY DISEASE; RISK-FACTORS;
   CARDIOVASCULAR-DISEASE; MYOCARDIAL-INFARCTION; METABOLIC SYNDROME;
   PROSPECTIVE COHORT; LIFE EVENTS; HEART; ATHEROSCLEROSIS
AB Background: A growing body of evidence suggests that psychological stress contributes to coronary artery disease. However, associations between stress and stroke are less clear. In this study, we investigated the possible association between ischemic stroke and self-perceived psychological stress, as measured by a single-item questionnaire, previously reported to be associated with myocardial infarction.
   Methods: In the Sahlgrenska Academy Study on Ischemic Stroke (SAHLSIS), 600 consecutive patients with acute ischemic stroke (aged 18 to 69 years) and 600 age-matched and sex-matched population controls were recruited. Ischemic stroke subtype was determined according to Trial of Org 10172 in Acute Stroke Treatment (TOAST) criteria. Self-perceived psychological stress preceding stroke was assessed retrospectively using a single-item questionnaire.
   Results: Permanent self-perceived psychological stress during the last year or longer was independently associated with overall ischemic stroke (multivariate adjusted odds ratio (OR) 3.49, 95% confidence interval (CI) 2.06 to 5.93). Analyses by stroke subtype showed that this association was present for large vessel disease (OR 3.91, 95% CI 1.58 to 9.67), small vessel disease (OR 3.20, 95% CI 1.64 to 6.24), and cryptogenic stroke (OR 4.03, 95% CI 2.34 to 6.95), but not for cardioembolic stroke (OR 1.48, 95% CI 0.64 to 3.39).
   Conclusion: In this case-control study, we found an independent association between self-perceived psychological stress and ischemic stroke. A novel finding was that this association differed by ischemic stroke subtype. Our results emphasize the need for further prospective studies addressing the potential role for psychological stress as a risk factor for ischemic stroke. In such studies ischemic stroke subtypes should be taken into consideration.
C1 [Jood, Katarina; Redfors, Petra; Blomstrand, Christian; Jern, Christina] Univ Gothenburg, Inst Neurosci & Physiol, Sahlgrenska Acad, Gothenburg, Sweden.
   [Rosengren, Annika] Sahlgrens Univ Hosp, Dept Med, Gothenburg, Sweden.
   [Jern, Christina] Sahlgrens Univ Hosp, Dept Clin Genet, Gothenburg, Sweden.
C3 University of Gothenburg; Sahlgrenska University Hospital; Sahlgrenska
   University Hospital
RP Jood, K (corresponding author), Univ Gothenburg, Inst Neurosci & Physiol, Sahlgrenska Acad, Gothenburg, Sweden.
EM katarina.jood@neuro.gu.se; petra.redfors@vgregion.se;
   annika.rosengren@hjl.gu.se; christian.blomstrand@neuro.gu.se;
   christina.jern@neuro.gu.se
OI Blomstrand, Christian/0000-0003-3503-860X
FU Swedish Research Council [VR 2007-2927]; Swedish Heart-Lung Foundation
   [20070404]; Swedish state under the LUA/ALF agreement [ALFGBG 11206];
   Health and Medical Care Executive Board of the Region Vastra Gotaland;
   Swedish Stroke Association; Goteborg Medical Society; Swedish Society of
   Medicine; Goteborg Foundation for Neurological Research; Rune and Ulla
   Amlovs Foundation for Neurological Research; John and Brit Wennerstrom
   Foundation for Neurological Research; The Per-Olof Ahl Foundation for
   Research; Yogve Land Foundation for Neurological Research; Pfizer
FX The present study was supported by the Swedish Research Council (VR
   2007-2927), the Swedish Heart-Lung Foundation (20070404), grants from
   the Swedish state under the LUA/ALF agreement (ALFGBG 11206), the Health
   and Medical Care Executive Board of the Region Vastra Gotaland, the
   Swedish Stroke Association, the Goteborg Medical Society, the Swedish
   Society of Medicine, the Goteborg Foundation for Neurological Research,
   the Rune and Ulla Amlovs Foundation for Neurological Research, the John
   and Brit Wennerstrom Foundation for Neurological Research, The Per-Olof
   Ahl Foundation for Research regarding Cerebrovascular diseases, the
   Yogve Land Foundation for Neurological Research, and a research grant
   from Pfizer (KJ). The funding sources did not participate in the design
   or conduct of the study; collection, management, analysis, or
   interpretation of the data; or preparation, review, or approval of the
   manuscript.
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NR 34
TC 67
Z9 78
U1 2
U2 14
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1741-7015
J9 BMC MED
JI BMC Med.
PD OCT 1
PY 2009
VL 7
AR 53
DI 10.1186/1741-7015-7-53
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA 512GW
UT WOS:000271235300001
PM 19796376
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Kim, MK
   Park, HJ
   Lee, KJ
AF Kim, Mi-Kyung
   Park, Hyo Jin
   Lee, Kyung Ju
TI Living lab modelling as a pilot study assessing the potential
   psychological health benefits of forest environment for cancer survivors
SO OBSTETRICS & GYNECOLOGY SCIENCE
LA English
DT Article
DE Forests; Relaxation therapy; Cancer survivors; Quality of life;
   Psychological well-being
ID QUALITY-OF-LIFE; METABOLIC SYNDROME; PREVALENCE; THERAPY
AB Objective To evaluate the physiological and psychological changes in cancer survivors who engage in repeated forest therapy in a living environment. Methods This study included stay-based forest therapy for female cancer survivors aged >= 40 years. The program was conducted in two cycles, each spanning 3 weeks and consisting of a 2-night, 3-day stay, followed by daily life integration. The cycles were repeated from July 2, 2022, to August 18, 2022. Participant assessment included standard physical health parameters and a questionnaire on general characteristics, lifestyle habits, stress levels, and health status. Results Thirty-seven female cancer survivors participated in the forest healing program, 56.8% of whom had a history of breast cancer. The median body mass index (BMI) was 23.80 kg/m 2 (range, 21.00-25.60). More than half of the patients reported mild-to-moderate fatigue, chronic pain, and mild-to-moderate depression (81%, 65%, and 73%, respectively). After two cycles of forest therapy, no significant differences were observed in terms of fatigue, pain, or BMI levels. However, significant improvements were found in quality of life measures, particularly the psychological quality of life (mean score 12.54 at baseline vs. 13.48 after cycle 2; P=0.007). Positive improvements were also observed in terms of stress (mean score 17.03 vs. 13.76; P=0.002) and depression (mean score 8.35 vs. 6.11; P=0.002) levels. Conclusion Our forest-healing program demonstrated that nature-based therapies improve the mental health and quality of life of female cancer survivors, suggesting the need for further research on nature-based interventions to better support cancer survivors.
C1 [Kim, Mi-Kyung] Ewha Womans Univ, Mokdong Hosp, Coll Med, Dept Obstet & Gynecol, Seoul 158710, South Korea.
   [Park, Hyo Jin] Ewha Womans Univ, Seoul Hosp, Coll Med, Dept Family Med, Seoul, South Korea.
   [Lee, Kyung Ju] Natl Rehabil Ctr, Dept Womens Rehabil, 58 Samgaksan Ro, Seoul 01022, South Korea.
C3 Ewha Womans University; Ewha Womans University
RP Lee, KJ (corresponding author), Natl Rehabil Ctr, Dept Womens Rehabil, 58 Samgaksan Ro, Seoul 01022, South Korea.
EM drlkj4094@korea.kr
RI Lee, Kyung Ju/AFL-9687-2022; Kim, Ee-Kyung/AAA-1068-2022
FU Korea Forestry Promotion Institute [2021384A00-2123-0101]
FX This research was funded by the Korea Forestry Promotion Institute
   (grant number: 2021384A00-2123-0101) .
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   Reed DL, 2016, J CLIN SLEEP MED, V12, P263, DOI 10.5664/jcsm.5498
   Salvador C, 2022, COMPLEMENT THER CLIN, V49, DOI 10.1016/j.ctcp.2022.101639
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   Yun BS, 2023, OBSTET GYNECOL SCI, V66, P545, DOI 10.5468/ogs.23208
NR 40
TC 0
Z9 0
U1 0
U2 3
PU Korean Soc Obstetrics and Gynecology (KSOG)
PI Seoul
PA 4th Floor, 36 Gangnam-daero 132-gil, Gangnam-gu, Seoul, SOUTH KOREA
SN 2287-8572
EI 2287-8580
J9 OBSTET GYNECOL SCI
JI Obstet. Gynecol. Sci.
PD JUL
PY 2024
VL 67
IS 4
BP 404
EP 413
DI 10.5468/ogs.24035eISSN2287-8580
PG 10
WC Obstetrics & Gynecology
WE Emerging Sources Citation Index (ESCI)
SC Obstetrics & Gynecology
GA YI5L2
UT WOS:001267873100005
DA 2025-06-11
ER

PT J
AU Flynn, M
   Houtjes, W
   Merks, A
   Van Mierlo, A
   Van de Wetering, B
AF Flynn, M.
   Houtjes, W.
   Merks, A.
   Van Mierlo, A.
   Van de Wetering, B.
TI Metabolic syndrome in mental health and addiction treatment: a
   quantitative study
SO JOURNAL OF PSYCHIATRIC AND MENTAL HEALTH NURSING
LA English
DT Article
DE Metabolic syndrome; addiction; dual diagnosis; mental health;
   schizophrenia
ID SCHIZOPHRENIA; MORTALITY; OBESITY; RISK
AB Accessible summary Patients with mental illnesses have been found to shorter life expectancy due to an increased risk of heart disease. Some medication used to treat mental illnesses have been linked to weight gain and other physical change that make patients susceptible to heart disease. In order to reduce this risk it is important that health professionals regularly measure and monitor signs of these physical changes. This research has found that measuring both waist circumference and blood pressure of patients is a safe and reliable way to way to monitor patients.
   AbstractTo identify if combined blood pressure and waist circumference measurements are reliable predictor of metabolic syndrome, a descriptive correlational design was used to examine the sensitivity and specificity of screening techniques used to detect metabolic syndrome. Data were collected regarding waist circumference, body mass index, blood pressure, fasting blood glucose, triglycerides and high-density lipoproteins. Blood pressure and waist circumference measurements demonstrated high significance, sensitivity and specificity as screening instruments for metabolic syndrome. Combined waist circumference and blood pressure measurements may be clinically useful for a quick and reliable detection of metabolic syndrome in patients with addiction and comorbid mental health problems.
C1 [Flynn, M.] Bouman GGZ, Inst Addict & Mental Hlth Care, Community Care Team FACT Feijenoord, NL-3035 HC Rotterdam, Netherlands.
   [Van Mierlo, A.] Bouman GGZ, Dept Educ & Training, Inst Addict & Mental Hlth Care, NL-3035 HC Rotterdam, Netherlands.
   [Van de Wetering, B.] Inst Addict & Mental Hlth Care, Rotterdam, Netherlands.
   [Houtjes, W.] Inst Educ Adv Nurse Practitioners Mental Hlth, Utrecht, Netherlands.
   [Merks, A.] Ermergis, Expert Ctr, Goes, Netherlands.
RP Flynn, M (corresponding author), Bouman GGZ, FACT Noord, Zaagmolenstr 60-62, NL-3035 HC Rotterdam, Netherlands.
EM m.flynn@boumanggz.nl
CR [Anonymous], 2002, 3 NAT CHOL ED PROGR
   [Anonymous], 2006, The IDF Consensus Worldwide Definition of the Metabolic Syndrome
   Brown S, 1997, BRIT J PSYCHIAT, V171, P502, DOI 10.1192/bjp.171.6.502
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   Laursen TM, 2011, SCHIZOPHR RES, V131, P101, DOI 10.1016/j.schres.2011.06.008
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   Weiden PJ, 2004, SCHIZOPHR RES, V66, P51, DOI 10.1016/S0920-9964(02)00498-X
NR 18
TC 1
Z9 1
U1 0
U2 15
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1351-0126
EI 1365-2850
J9 J PSYCHIATR MENT HLT
JI J. Psychiatr. Ment. Health Nurs.
PD FEB
PY 2015
VL 22
IS 1
BP 15
EP 19
DI 10.1111/jpm.12166
PG 5
WC Nursing; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Psychiatry
GA CA2AO
UT WOS:000348711600003
PM 25376964
DA 2025-06-11
ER

PT J
AU Hoffmann, MS
   Brunoni, AR
   Stringaris, A
   Viana, MC
   Lotufo, PA
   Benseñor, IM
   Salum, GA
AF Hoffmann, Mauricio Scopel
   Brunoni, Andre Russowsky
   Stringaris, Argyris
   Viana, Maria Carmen
   Lotufo, Paulo Andrade
   Bensenor, Isabela Martins
   Salum, Giovanni Abrahao
TI Common and specific aspects of anxiety and depression and the metabolic
   syndrome
SO JOURNAL OF PSYCHIATRIC RESEARCH
LA English
DT Article
DE Structural equation model; Diabetes mellitus; Obesity; Hypertension;
   Dyslipidemia; Negative affect; HiTOP
ID CLINICAL INTERVIEW SCHEDULE; STANDARDIZED ASSESSMENT; PSYCHIATRIC
   MORBIDITY; GENERAL FACTOR; CIS-R; ASSOCIATION; ADULTS; PSYCHOPATHOLOGY;
   NEUROECONOMICS; METAANALYSIS
AB Introduction: The associations of anxiety and depression with metabolic syndrome (MetS) are not consistent across studies. Anxiety and depression are highly correlated and traditional methods don?t take the structure of this correlation into account. Our aim is to disentangle the relationship of these emotional conditions with MetS, using bifactor models, modelling both general and specific aspects between anxiety and depression. Methods: Bifactor models were tested using the baseline data from the Brazilian Longitudinal Study of Adult Health (n = 13,584). Anxiety and depression were accessed with the Clinical Interview Schedule - Revised. MetS was measured through assessment of its continuous components. Results: A bifactor S-1 model better represent the 14 CIS-R indicators, composed by an internalizing factor corresponding to depressive symptoms, anxiety, worry and the shared variance of all remaining CIS-R indicators, and also by residual variance explained by a somatic (e.g., fatigue and pain) and fear (e.g., panic and phobias) specific factors. Internalizing spectrum (13 = 0.116; p < 0.001) and the fear specific factor (13 = 0.060; p = 0.008) were associated with MetS after adjusting for confounders, whereas somatic specific factor was unlikely to be associated with MetS (13 = 0.002; p = 0.934). Conclusions: Anxiety and depression indicators were associated with MetS via a shared internalizing factor and also by a residual fear factor, but not by somatic residual factor. This finding has potential implications about shared biological and behavioral mechanisms that may link emotional conditions with MetS in adults.
C1 [Hoffmann, Mauricio Scopel] Univ Fed Santa Maria, Dept Neuropsiquiatria, Ave Roraima 1000, BR-97105900 Santa Maria, RS, Brazil.
   [Hoffmann, Mauricio Scopel; Salum, Giovanni Abrahao] Univ Fed Rio Grande do Sul, Hosp Clin Porto Alegre, Sect Negat Affect & Social Proc, Ramiro Barcelos 2350, BR-90035003 Porto Alegre, RS, Brazil.
   [Hoffmann, Mauricio Scopel; Salum, Giovanni Abrahao] Hosp Clin Porto Alegre, Ramiro Barcelos 2350, BR-90035003 Porto Alegre, RS, Brazil.
   [Brunoni, Andre Russowsky; Lotufo, Paulo Andrade; Bensenor, Isabela Martins] Univ Sao Paulo, Hosp Univ, Fac Med, Ctr Pesquisa Clin & Epidemiol, Sao Paulo, Brazil.
   [Brunoni, Andre Russowsky; Lotufo, Paulo Andrade; Bensenor, Isabela Martins] Univ Sao Paulo, Lab Neurosci LIM 27, Inst Nacl Biomarcadores Neuropsiquiatria Inb, Dept & Inst Psychiat,Fac Med, R Dr Ovidio Pires de Campos 785,2o Andar, BR-05403000 Sao Paulo, Brazil.
   [Stringaris, Argyris] NIMH, Emot & Dev Branch, NIH, Bethesda, MD 20892 USA.
   [Viana, Maria Carmen] Univ Fed Espirito Santo, Dept Social Med, Postgrad Program Publ Hlth, Av Maruipe 1468, BR-29047105 Vitoria, ES, Brazil.
   [Salum, Giovanni Abrahao] Univ Fed Rio Grande do Sul, Dept Psychiat, Rua Ramiro Barcelos 2350, BR-90035003 Porto Alegre, RS, Brazil.
C3 Universidade Federal de Santa Maria (UFSM); Universidade Federal do Rio
   Grande do Sul; Hospital de Clinicas de Porto Alegre; Hospital de
   Clinicas de Porto Alegre; Universidade de Sao Paulo; Universidade de Sao
   Paulo; National Institutes of Health (NIH) - USA; NIH National Institute
   of Mental Health (NIMH); Universidade Federal do Espirito Santo;
   Universidade Federal do Rio Grande do Sul
RP Hoffmann, MS (corresponding author), Univ Fed Rio Grande do Sul, Hosp Clin Porto Alegre, Ramiro Barcelos 2350, BR-90035 Porto Alegre, RS, Brazil.
EM mauricio.hoffmann@ufsm.br; brunowsky@gmail.com;
   argyris.stringaris@nih.gov; mcviana6@gmail.com; paulo.lotufo@gmail.com;
   isabensenor@gmail.com; gsalumjr@gmail.com
RI Salum, Giovanni/A-7849-2010; Hoffmann, Mauricio/AAM-9899-2020; Bensenor,
   Isabela/L-3306-2017; Lotufo, Paulo/A-9843-2008; Stringaris,
   Argyris/N-1135-2017; Russowsky Brunoni, Andre/H-8394-2012
OI Scopel Hoffmann, Mauricio/0000-0003-4232-3169; Stringaris,
   Argyris/0000-0002-6264-8377; Russowsky Brunoni,
   Andre/0000-0002-6310-3571; Bensenor, Isabela/0000-0002-6723-5678
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NR 65
TC 10
Z9 10
U1 5
U2 11
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-3956
EI 1879-1379
J9 J PSYCHIATR RES
JI J. Psychiatr. Res.
PD MAY
PY 2021
VL 137
BP 117
EP 125
DI 10.1016/j.jpsychires.2021.02.052
EA MAR 2021
PG 9
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA RT4MC
UT WOS:000644433900017
PM 33677215
DA 2025-06-11
ER

PT J
AU Rampersaud, R
   Wu, GWY
   Reus, VI
   Lin, J
   Blackburn, EH
   Epel, ES
   Hough, CM
   Mellon, SH
   Wolkowitz, OM
AF Rampersaud, Ryan
   Wu, Gwyneth W. Y.
   Reus, Victor I.
   Lin, Jue
   Blackburn, Elizabeth H.
   Epel, Elissa S.
   Hough, Christina M.
   Mellon, Synthia H.
   Wolkowitz, Owen M.
TI Shorter telomere length predicts poor antidepressant response and poorer
   cardiometabolic indices in major depression
SO SCIENTIFIC REPORTS
LA English
DT Article
ID CARDIOVASCULAR-DISEASE; OXIDATIVE STRESS; ALLOSTATIC LOAD;
   PSYCHIATRIC-DISORDERS; HIPPOCAMPAL VOLUME; FOLLOW-UP; LIFE-SPAN; HUMAN
   T; ASSOCIATION; ANXIETY
AB Telomere length (TL) is a marker of biological aging, and shorter telomeres have been associated with several medical and psychiatric disorders, including cardiometabolic dysregulation and Major Depressive Disorder (MDD). In addition, studies have shown shorter TL to be associated with poorer response to certain psychotropic medications, and our previous work suggested shorter TL and higher telomerase activity (TA) predicts poorer response to Selective Serotonin Reuptake Inhibitor (SSRI) treatment. Using a new group of unmedicated medically healthy individuals with MDD (n = 48), we sought to replicate our prior findings demonstrating that peripheral blood mononuclear cell (PBMC) TL and TA predict response to SSRI treatment and to identify associations between TL and TA with biological stress mediators and cardiometabolic risk indices. Our results demonstrate that longer pre-treatment TL was associated with better response to SSRI treatment (& beta; = .407 p = .007). Additionally, we observed that TL had a negative relationship with allostatic load (& beta; = - .320 p = .017) and a cardiometabolic risk score (& beta; = - .300 p = .025). Our results suggest that PBMC TL reflects, in part, the cumulative effects of physiological stress and cardiovascular risk in MDD and may be a biomarker for predicting SSRI response.
C1 [Rampersaud, Ryan; Wu, Gwyneth W. Y.; Reus, Victor I.; Epel, Elissa S.; Hough, Christina M.; Wolkowitz, Owen M.] Univ Calif San Francisco UCSF, Weill Inst Neurosci, Sch Med, San Francisco, CA 94158 USA.
   [Rampersaud, Ryan; Wu, Gwyneth W. Y.; Reus, Victor I.; Epel, Elissa S.; Hough, Christina M.; Wolkowitz, Owen M.] Univ Calif San Francisco UCSF, Dept Psychiat & Behav Sci, Sch Med, San Francisco, CA 94143 USA.
   [Lin, Jue; Blackburn, Elizabeth H.] Univ Calif San Francisco UCSF, Dept Biochem & Biophys, Sch Med, San Francisco, CA USA.
   [Mellon, Synthia H.] UCSF, Dept OB GYN & Reprod Sci, Sch Med, San Francisco, CA USA.
   [Hough, Christina M.] Univ Calif Los Angeles UCLA, Dept Psychol, Los Angeles, CA USA.
C3 University of California System; University of California San Francisco;
   University of California System; University of California San Francisco;
   University of California System; University of California San Francisco;
   University of California System; University of California San Francisco;
   University of California System; University of California Los Angeles
RP Rampersaud, R (corresponding author), Univ Calif San Francisco UCSF, Weill Inst Neurosci, Sch Med, San Francisco, CA 94158 USA.; Rampersaud, R (corresponding author), Univ Calif San Francisco UCSF, Dept Psychiat & Behav Sci, Sch Med, San Francisco, CA 94143 USA.
EM ryan.rampersaud@ucsf.edu
RI Epel, Elissa/ABI-6703-2022; Wolkowitz, Owen/J-6649-2013; reus,
   victor/I-7923-2015
FU Institute of Mental Health (NIMH) [R01-MH083784]; Tinberg family; UCSF
   Academic Senate; UCSF Research Evaluation and Allocation Committee;
   National Institutes of Health/National Center for Research Resources;
   National Center for Advancing Translational Sciences, NIH through
   UCSF-CTSI [UL1 RR024131, TL-1 TR001871];  [NCT00285935]; National Center
   for Advancing Translational Sciences [TL1TR001871] Funding Source: NIH
   RePORTER
FX The authors acknowledge the assistance of Phuong Hoang, Stacy Ann
   Miller, the UCSF CTSI Clinical Research Center staff, the PNE Lab
   research assistants, volunteers and research participants. This study
   was funded by grants from the Institute of Mental Health (NIMH)
   (R01-MH083784), the Tinberg family, UCSF Academic Senate, and UCSF
   Research Evaluation and Allocation Committee. This project was also
   supported by National Institutes of Health/National Center for Research
   Resources and the National Center for Advancing Translational Sciences,
   NIH, through UCSF-CTSI Grant UL1 RR024131 and TL-1 TR001871. Clinical
   Trial Registry Number (NCT00285935). None of the funding agencies had a
   role in the design/conduct of the study; collection, management,
   analysis, and interpretation of the data; and preparation, review, or
   approval of the manuscript.
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NR 121
TC 7
Z9 7
U1 0
U2 7
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD JUN 23
PY 2023
VL 13
IS 1
AR 10238
DI 10.1038/s41598-023-35912-z
PG 14
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA K8FQ8
UT WOS:001018745700056
PM 37353495
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Pouragha, H
   Alamdari, RJ
   Pouryaghoub, G
   Saraei, M
   Mehrdad, R
AF Pouragha, Hamidreza
   Alamdari, Rita Javadi
   Pouryaghoub, Gholamreza
   Saraei, Maryam
   Mehrdad, Ramin
TI Is Having a Permanent Job a Predictor of Metabolic Syndrome?
SO ENDOCRINOLOGY RESEARCH AND PRACTICE
LA English
DT Article
DE Metabolic syndrome X; Occupational groups; employment status
ID WORK-FAMILY CONFLICT; RISK-FACTORS; CARDIOVASCULAR RISK; ASSOCIATION;
   PREVALENCE; SLEEP; HYPERTENSION; ENVIRONMENT; OVERTIME; STRESS
AB Objective: Many non-occupational and occupational metabolic syndrome risk factors have been identified. In this study, we examined some occupational risk factors of metabolic syndrome.
   Methods: 3537 employees of Tehran University of Medical Sciences, (1388 male and 2139 female) participated in this cross-sectional study. The prevalence of metabolic syndrome was measured using the International Diabetes Federation criteria, and then we evaluated the association between some job variables such as work-family conflict, shift working, occupational groups and employment status, and metabolic syndrome.
   Result: According to the International Diabetes Federation criteria, the prevalence of metabolic syndrome among employees of Tehran University of Medical Sciences was 22.1%, which was 25.3% and 20.0% for men and women, respectively. In the regression model without the presence of metabolic syndrome component, age, occupational groups, and having a permanent job were predictors of metabolic syndrome. In the model with the presence of metabolic syndrome components, in addition to the metabolic syndrome components, gender and having a permanent job were observed as metabolic syndrome predictors. The study found no association between work-family conflict and metabolic syndrome.
   Conclusion: Having a permanent job is introduced as an occupational predictor of metabolic syndrome.
C1 [Pouragha, Hamidreza; Alamdari, Rita Javadi; Pouryaghoub, Gholamreza; Mehrdad, Ramin] Univ Tehran Med Sci, Ctr Res Occupat Dis, Tehran, Iran.
   [Pouragha, Hamidreza] Mehralborz Univ MAU, Dept Environm Engn, Tehran, Iran.
   [Saraei, Maryam] Univ Tehran Med Sci, Dept Occupat Med, Fac Med, Baharlou Hosp, Tehran, Iran.
C3 Tehran University of Medical Sciences; Tehran University of Medical
   Sciences
RP Mehrdad, R (corresponding author), Univ Tehran Med Sci, Ctr Res Occupat Dis, Tehran, Iran.
EM mehrdadr@tums.ac.ir
RI pouragha, hamidreza/JVZ-3553-2024; saraei, maryam/AAT-1236-2020
OI Pouragha, Hamidreza/0000-0002-9748-2864
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NR 52
TC 0
Z9 0
U1 0
U2 1
PU AVES
PI SISLI
PA BUYUKDERE CAD 105-9, MECIDIYEKOY, SISLI, ISTANBUL 34394, Turkiye
EI 2822-6135
J9 ENDOCRINOL RES PRACT
JI Endocrinol. Res. Pract.
PD APR
PY 2023
VL 27
IS 2
BP 65
EP 70
DI 10.5152/erp.2023.225079
PG 6
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA Z2FV3
UT WOS:001110296900006
OA gold
DA 2025-06-11
ER

PT J
AU Mazgelyte, E
   Mazeikiene, A
   Burokiene, N
   Matuzeviciene, R
   Linkeviciute, A
   Kucinskiene, ZA
   Karciauskaite, D
AF Mazgelyte, Egle
   Mazeikiene, Asta
   Burokiene, Neringa
   Matuzeviciene, Reda
   Linkeviciute, Ausra
   Kucinskiene, Zita Ausrele
   Karciauskaite, Dovile
TI Association between hair cortisol concentration and metabolic syndrome
SO OPEN MEDICINE
LA English
DT Article
DE cortisol; metabolic syndrome; psychosocial stress
ID PITUITARY-ADRENAL AXIS; SALIVARY CORTISOL; PERCEIVED STRESS;
   PATHOGENESIS; MEN; DISORDER; MARKER
AB Metabolic syndrome (MetS) is a highly prevalent disorder defined as a cluster of cardiometabolic risk factors including obesity, hyperglycemia, hypertension, and dyslipidemia. It is believed that excessive cortisol secretion due to psychosocial stress-induced hypothalamic-pituitary-adrenal axis activation might be involved in the pathogenesis of MetS. We sought to explore the association between MetS and psychosocial risk factors, as well as cortisol concentration measured in different biological specimens including saliva, blood serum, and hair samples. The study was conducted on a sample of 163 young and middle-aged men who were divided into groups according to the presence of MetS. Hair cortisol concentration (HCC) was determined using high performance liquid chromatography with UV detection, while blood serum and salivary cortisol levels were measured by enzyme-linked immunoassay. Lipid metabolism biomarkers were determined using routine laboratory methods. Anthropometric and lifestyle characteristics, as well as self-reported psychosocial indicators, were also examined. Significantly higher HCC and lower social support level among participants with MetS compared with individuals without MetS were found. However, no significant differences in blood serum and salivary cortisol levels were observed between men with and without MetS. In conclusion, chronically elevated cortisol concentration might be a potential contributing factor to the development of MetS.
C1 [Mazgelyte, Egle; Mazeikiene, Asta; Matuzeviciene, Reda; Linkeviciute, Ausra; Kucinskiene, Zita Ausrele; Karciauskaite, Dovile] Vilnius Univ, Dept Physiol Biochem Microbiol & Lab Med, Inst Biomed Sci, Fac Med, Vilnius, Lithuania.
   [Burokiene, Neringa] Vilnius Univ, Inst Clin Med, Clin Internal Dis Family Med & Oncol, Vilnius, Lithuania.
C3 Vilnius University; Vilnius University
RP Mazgelyte, E (corresponding author), Vilnius Univ, Dept Physiol Biochem Microbiol & Lab Med, Inst Biomed Sci, Fac Med, Vilnius, Lithuania.
EM egle.mazgelyte@mf.vu.lt
RI Karciauskaite, Dovile/NGR-6322-2025; Matuzeviciene, Reda/GSI-5971-2022;
   Mazeikiene, Asta/NGQ-8907-2025; Mazgelyte, Egle/GXM-8634-2022
OI Linkeviciute-Dumce, Ausra/0000-0001-8682-4251; Mazeikiene,
   Asta/0000-0002-3308-068X; Mazgelyte, Egle/0000-0002-1033-0607
FU Research Council of Lithuania [MIP-050/2015]
FX This work was supported by the Research Council of Lithuania (Grant No.
   MIP-050/2015).
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NR 47
TC 0
Z9 0
U1 0
U2 5
PU DE GRUYTER POLAND SP Z O O
PI WARSAW
PA BOGUMILA ZUGA 32A STR, 01-811 WARSAW, MAZOVIA, POLAND
SN 2391-5463
J9 OPEN MED-WARSAW
JI Open Med.
PD JUN 16
PY 2021
VL 16
IS 1
BP 873
EP 881
DI 10.1515/med-2021-0298
PG 9
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA TR9VP
UT WOS:000679306500002
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Meister, R
   Princip, M
   Schmid, JP
   Schnyder, U
   Barth, J
   Znoj, H
   Herbert, C
   von Känel, R
AF Meister, Rebecca
   Princip, Mary
   Schmid, Jean-Paul
   Schnyder, Ulrich
   Barth, Juergen
   Znoj, Hansjoerg
   Herbert, Claudia
   von Kaenel, Roland
TI Myocardial Infarction - Stress PRevention INTervention (MI-SPRINT) to
   reduce the incidence of posttraumatic stress after acute myocardial
   infarction through trauma-focused psychological counseling: study
   protocol for a randomized controlled trial
SO TRIALS
LA English
DT Article
DE Anxiety disorder; Biomarkers; Cardiovascular disease; Counseling;
   Myocardial infarction; Posttraumatic stress disorder; Prevention;
   Psychological stress; Psychotherapy; Randomized controlled trial
ID CORONARY-HEART-DISEASE; SELF-REPORT MEASURE; QUALITY-OF-LIFE; DISORDER
   SYMPTOMS; GERMAN VERSION; HEALTH-STATUS; RISK-FACTORS; SCALE; PTSD;
   DISTRESS
AB Background: Posttraumatic Stress Disorder (PTSD) may occur in patients after exposure to a life-threatening illness. About one out of six patients develop clinically relevant levels of PTSD symptoms after acute myocardial infarction (MI). Symptoms of PTSD are associated with impaired quality of life and increase the risk of recurrent cardiovascular events. The main hypothesis of the MI-SPRINT study is that trauma-focused psychological counseling is more effective than non-trauma focused counseling in preventing posttraumatic stress after acute MI.
   Methods/Design: The study is a single-center, randomized controlled psychological trial with two active intervention arms. The sample consists of 426 patients aged 18 years or older who are at 'high risk' to develop clinically relevant posttraumatic stress symptoms. 'High risk' patients are identified with three single-item questions with a numeric rating scale (0 to 10) asking about 'pain during MI', 'fear of dying until admission' and/or 'worrying and feeling helpless when being told about having MI'. Exclusion criteria are emergency heart surgery, severe comorbidities, current severe depression, disorientation, cognitive impairment and suicidal ideation. Patients will be randomly allocated to a single 45-minute counseling session targeting either specific MI-triggered traumatic reactions (that is, the verum intervention) or the general role of psychosocial stress in coronary heart disease (that is, the control intervention). The session will take place in the coronary care unit within 48 hours, by the bedside, after patients have reached stable circulatory conditions. Each patient will additionally receive an illustrated information booklet as study material. Sociodemographic factors, psychosocial and medical data, and cardiometabolic risk factors will be assessed during hospitalization. The primary outcome is the interviewer-rated posttraumatic stress level at three-month follow-up, which is hypothesized to be at least 20% lower in the verum group than in the control group using the t-test. Secondary outcomes are posttraumatic stress levels at 12-month follow-up, and psychosocial functioning and cardiometabolic risk factors at both follow-up assessments.
   Discussion: If the verum intervention proves to be effective, the study will be the first to show that a brief trauma-focused psychological intervention delivered within a somatic health care setting can reduce the incidence of posttraumatic stress in acute MI patients.
C1 [Meister, Rebecca; Princip, Mary; von Kaenel, Roland] Univ Bern, Inselspital, Univ Hosp Bern, Dept Gen Internal Med,Div Psychosomat Med, CH-3010 Bern, Switzerland.
   [Meister, Rebecca; Princip, Mary; von Kaenel, Roland] Univ Bern, Dept Clin Res, Bern, Switzerland.
   [Meister, Rebecca; Princip, Mary; Znoj, Hansjoerg] Univ Bern, Div Clin Psychol & Psychotherapy, Inst Psychol, Bern, Switzerland.
   [Schmid, Jean-Paul; von Kaenel, Roland] Univ Bern, Inselspital, Univ Hosp Bern, Dept Cardiol Cardiovasc Prevent Rehabil & Sports, CH-3010 Bern, Switzerland.
   [Schnyder, Ulrich] Univ Zurich Hosp, Dept Psychiat & Psychotherapy, CH-8091 Zurich, Switzerland.
   [Barth, Juergen] Univ Bern, Inst Social & Prevent Med, Bern, Switzerland.
   [Herbert, Claudia] Oxford Dev Ctr Ltd, Oxford, Oxon, England.
C3 University of Bern; University Hospital of Bern; University of Bern;
   University of Bern; University of Bern; University Hospital of Bern;
   University of Zurich; University Zurich Hospital; University of Bern
RP von Känel, R (corresponding author), Univ Bern, Inselspital, Univ Hosp Bern, Dept Gen Internal Med,Div Psychosomat Med, CH-3010 Bern, Switzerland.
EM roland.vonkaenel@insel.ch
RI Znoj, Hans/C-2727-2014; Schnyder, Ulrich/JGD-0205-2023; Barth,
   Jurgen/F-9987-2011; von Kanel, Roland/B-1811-2019
OI Schnyder, Ulrich/0000-0003-3556-7990; Barth, Jurgen/0000-0001-7096-7178;
   von Kanel, Roland/0000-0002-8929-5129
FU Swiss National Science Foundation [140960]; Teaching and Research
   Directorate, Bern University Hospital, Switzerland
FX The MI-SPRINT study is funded by the Swiss National Science Foundation
   (project number 140960, principal investigator: RvK). Additional
   financial support comes from the Teaching and Research Directorate, Bern
   University Hospital, Switzerland. The funding bodies had no influence on
   the study design, in the writing of the manuscript, and in the decision
   to submit the manuscript for publication.
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NR 80
TC 39
Z9 39
U1 1
U2 29
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1745-6215
J9 TRIALS
JI Trials
PD OCT 11
PY 2013
VL 14
AR 329
DI 10.1186/1745-6215-14-329
PG 11
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Research & Experimental Medicine
GA 235NI
UT WOS:000325725600001
PM 24119487
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Bilaç, Ö
   Tahillioglu, A
   Çakir, B
   Kavurma, C
   Önder, A
   Ercan, ES
AF Bilac, Oznur
   Tahillioglu, Akin
   Cakir, Burak
   Kavurma, Canem
   Onder, Arif
   Ercan, Eyup Sabri
TI Is There Any Risk for Metabolic Syndrome in Children and Adolescents
   with Psychiatric Disorders?
SO DUBAI MEDICAL JOURNAL
LA English
DT Article
DE Metabolic syndrome; Weight gain; Blood pressure; Antipsychotics;
   Psychiatric disorder; Bipolar disorder; Children and adolescents;
   Quetiapine; Valproic acid
ID MAJOR DEPRESSIVE DISORDER; ANTIPSYCHOTIC MEDICATIONS;
   CARDIOVASCULAR-DISEASE; 2ND-GENERATION ANTIPSYCHOTICS; NATIONAL-HEALTH;
   ADVERSE EVENTS; DOUBLE-BLIND; WEIGHT-GAIN; SCHIZOPHRENIA; PREVALENCE
AB Objective: We aimed to investigate the risk of antipsychotic drug treatment in the development of metabolic syndrome (MetS) in children and adolescents and to determine which psychiatric disorder is more associated with MetS in the pediatric population. Methods: The sample consisted of 118 children and adolescents (88 used psychotropic medication). The hemogram, fasting blood glucose, lipid profile, weight, and blood pressure levels of all the participants and information regarding medication doses of the patient group at the sixth month of the treatment process were obtained. Results: Bipolar disorder (BPD) was the only psychiatric disorder associated with MetS. Quetiapine and valproic acid were found to have increasing effects on MetS. Weight gain and the increase in systolic and diastolic blood pressure significantly increased the likelihood of MetS. Hierarchical logistic regression analyses revealed that quetiapine increased the risk of MetS through weight gain, and valproic acid increased MetS risk through systolic blood pressure. Conclusion: Especially BPD and psychotropic use in children and adolescents disrupt metabolic regulation and pose a risk for MetS. Determining the risk factors causing MetS, especially in children and adolescents, plays a significant role in preventing mortality and morbidity at advanced ages.
C1 [Bilac, Oznur] Manisa Celal Bayar Univ, Dept Child & Adolescent Psychiat, Manisa, Turkiye.
   [Tahillioglu, Akin] Bakircay Univ, Cigli Reg Educ Hosp, Dept Child & Adolescent Psychiat, Izmir, Turkiye.
   [Cakir, Burak] Usak Educ & Res Hosp, Dept Child & Adolescent Psychiat, Usak, Turkiye.
   [Kavurma, Canem] Dr Behcet Uz Pediat Dis & Surg Training & Res Hosp, Dept Child & Adolescent Psychiat, Izmir, Turkiye.
   [Onder, Arif] Akdeniz Univ, Dept Child & Adolescent Psychiat, Antalya, Turkiye.
   [Ercan, Eyup Sabri] Ege Univ, Dept Child & Adolescent Psychiat, Izmir, Turkiye.
C3 Celal Bayar University; Izmir University of Bakircay; Akdeniz
   University; Ege University
RP Çakir, B (corresponding author), Usak Educ & Res Hosp, Dept Child & Adolescent Psychiat, Usak, Turkiye.
RI Tahıllıoğlu, Akın/HLG-4928-2023; Bilac, Oznur/GOH-0097-2022; Onder,
   Arif/AAJ-6947-2020
OI Onder, Arif/0000-0003-0571-9295
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NR 52
TC 0
Z9 0
U1 0
U2 2
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
EI 2571-726X
J9 DUBAI MED J
JI Dubai Med. J.
PD DEC
PY 2023
VL 6
IS 4
BP 261
EP 273
DI 10.1159/000533470
EA SEP 2023
PG 13
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA AA5Y5
UT WOS:001069791400001
OA gold
DA 2025-06-11
ER

PT J
AU Trief, PM
   Cibula, D
   Delahanty, LM
   Weinstock, RS
AF Trief, Paula M.
   Cibula, Donald
   Delahanty, Linda M.
   Weinstock, Ruth S.
TI Depression, Stress, and Weight Loss in Individuals with Metabolic
   Syndrome in SHINE, a DPP Translation Study
SO OBESITY
LA English
DT Article
ID DIABETES PREVENTION PROGRAM; LIFE-STYLE INTERVENTION; PREDICTORS;
   OUTCOMES; ADULTS
AB ObjectiveTo examine the relationships between elevated depression symptoms (EDS) or stress and weight loss in SHINE, a telephonic, primary-care based, translation of the Diabetes Prevention Program.
   MethodsN=257 adults with metabolic syndrome were randomized to individual (IC) or group (CC) phone participation. Weight, depression, anti-depressant use (ADMs), and stress (baseline, 6 months, 1 and 2 years) were assessed. Univariate analyses used linear and logistic regression, t tests for continuous variables and exact tests for categorical variables. Stratified analyses assessed modifiers of effects of depression/stress on weight loss.
   ResultsApproximately 35% reported EDS, with no change over time. Approximately 28% of all participants used ADMs. Participants with EDS had lower mean % weight loss and a smaller % who achieved 5% weight loss. Participants with EDS were less likely to be completers (40.1% vs. 61.5%, P=0.002), coached (48.0% vs. 60.7%, P=0.049), or log diet/activity (19.4% vs. 42.7%, P<0.001), behaviors related to weight loss. Results were similar for high stress. ADM use had no independent effect on weight loss.
   ConclusionsIndividuals with metabolic syndrome and EDS and/or high stress were less likely to lose significant weight. Pre-intervention depression and stress screening to intervene may improve weight loss.
C1 [Trief, Paula M.] SUNY Upstate Med Univ, Dept Psychiat & Behav Sci, New York, NY 13210 USA.
   [Trief, Paula M.; Weinstock, Ruth S.] SUNY Upstate Med Univ, Dept Med, New York, NY USA.
   [Cibula, Donald] SUNY Upstate Med Univ, Dept Publ Hlth & Prevent Med, New York, NY USA.
   [Delahanty, Linda M.] Massachusetts Gen Hosp, Diabet Res Ctr, Boston, MA 02114 USA.
   [Delahanty, Linda M.] Harvard Univ, Dept Med, Cambridge, MA 02138 USA.
C3 State University of New York (SUNY) System; State University of New York
   (SUNY) Upstate Medical Center; State University of New York (SUNY)
   System; State University of New York (SUNY) Upstate Medical Center;
   State University of New York (SUNY) System; State University of New York
   (SUNY) Upstate Medical Center; Harvard University; Harvard University
   Medical Affiliates; Massachusetts General Hospital; Harvard University
RP Trief, PM (corresponding author), SUNY Upstate Med Univ, Dept Psychiat & Behav Sci, New York, NY 13210 USA.
EM triefp@upstate.edu
RI Trief, Paula/T-6116-2019
OI Trief, Paula/0000-0002-2827-5722
FU National Institutes of Health [R18-DK078553]
FX Funding agencies: Study supported by grant R18-DK078553, National
   Institutes of Health.
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   [Anonymous], DIABETES PREVENTION
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NR 25
TC 33
Z9 39
U1 0
U2 12
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1930-7381
EI 1930-739X
J9 OBESITY
JI Obesity
PD DEC
PY 2014
VL 22
IS 12
BP 2532
EP 2538
DI 10.1002/oby.20916
PG 7
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA AU1XA
UT WOS:000345409500012
PM 25251749
OA Green Accepted, Green Submitted
DA 2025-06-11
ER

PT J
AU Roettger, ME
   Tan, J
   Houle, B
   Najman, JM
   McGee, T
AF Roettger, Michael E.
   Tan, Jolene
   Houle, Brian
   Najman, Jake M.
   McGee, Tara
TI Parental imprisonment, childhood behavioral problems, and adolescent and
   young adult cardiometabolic risk: results from a prospective Australian
   birth cohort study
SO HEALTH & JUSTICE
LA English
DT Article
DE Parental imprisonment; Behavioral problems; Body mass index; Systolic
   blood pressure; Diastolic blood pressure; Waist circumference;
   Cardiometabolic risk
ID PATERNAL INCARCERATION; MENTAL-HEALTH; FAMILY-MEMBER; MATERNAL
   INCARCERATION; SEX-DIFFERENCES; BLOOD-PRESSURE; DISPARITIES; STRESS;
   ASSOCIATIONS; FATHERS
AB ObjectivesRecent studies have demonstrated that parental imprisonment (PI) is associated with cardiometabolic risk later in life. However, underlying risk factors for these associations have not previously been explored. Using a life course framework, the present study explores how early childhood emotional and behavioral dysregulation and PI may be associated with progressive cardiometabolic risk factors in adolescence and young adulthood among male and female respondents in an Australian birth cohort.MethodsThe study follows a subset of 7,223 live, singleton births from 1981 to 1984 in Brisbane, Australia where data was collected on parental imprisonment at ages 5 & 14 and behaviors from the Child Behavioral Checklist (CBCL) at age 5. Our sample examines 1,884 males and 1,758 females whose mothers completed prenatal, age 5, and age 14 interviews and respondents completed one or more interviews at a health clinic at ages 14, 21, and 30. Multivariate regression was used to examine cross-sectional results, while individual growth models examined longitudinal patterns.ResultsDividing the analysis by sex, we examined how parental imprisonment was potentially mediated or moderated by CBCL subscale measures for aggression, social-attention-thought (SAT) disorders, internalizing, and depression. No associations were found among male respondents. Among female respondents, controlling for these behaviors, there was a significant association between parental imprisonment and higher systolic blood pressure at age 30, while all CBCL measures were found to moderate waist circumference at age 30 and BMI at ages 14, 21, and/or 30. Using individual growth curve modelling, we observed the increased CBCL aggression and SAT scores were increasingly associated with higher BMI as respondents aged in adulthood.ConclusionsUsing prospective cohort data, our results suggest that PI and emotional and behavioral dysregulation are associated with BMI, systolic blood pressure, and waist circumference in females, along with potentially increasing levels of cardiometabolic risk, as measured by increased BMI, from age 14 through age 30. The result is suggestive of the importance of examining early emotional/behavioral problems and PI as joint risk factors for developing cardiometabolic risk factors that may progress into cardiometabolic diseases at later stages in the life course.
C1 [Roettger, Michael E.; Tan, Jolene; Houle, Brian] Australian Natl Univ, Sch Demog, 146 Ellery Crescent, Acton, ACT 2601, Australia.
   [Houle, Brian] Univ Witwatersrand, Fac Hlth Sci, Sch Publ Hlth, MRC Wits Rural Publ Hlth & Hlth Transit Res Unit A, Johannesburg, South Africa.
   [Najman, Jake M.] Univ Queensland, Sch Publ Hlth, Publ Hlth Bldg, Herston 4006, Australia.
   [McGee, Tara] Griffith Univ, Sch Criminol & Criminal Justice, 176 Messines Ridge Rd, Mt Gravatt, Qld 4122, Australia.
C3 Australian National University; University of Witwatersrand; University
   of Queensland; Griffith University; Griffith University - Mount Gravatt
   Campus
RP Roettger, ME (corresponding author), Australian Natl Univ, Sch Demog, 146 Ellery Crescent, Acton, ACT 2601, Australia.
EM mike.roettger@anu.edu.au
RI McGee, Tara Renae/IZQ-4686-2023; Tan, Jolene/GXF-8878-2022; Najman,
   Jackob/B-1527-2008; Roettger, Michael/ABA-6927-2020
OI Tan, Jolene/0000-0003-4968-3482; Roettger, Michael/0000-0002-8253-5927
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   Yang YC, 2016, P NATL ACAD SCI USA, V113, P578, DOI 10.1073/pnas.1511085112
   Young R, 2015, J MARRIAGE FAM, V77, P277, DOI 10.1111/jomf.12144
NR 105
TC 0
Z9 0
U1 1
U2 1
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
EI 2194-7899
J9 HEAL JUSTICE
JI Health Justice
PD APR 30
PY 2025
VL 13
IS 1
AR 29
DI 10.1186/s40352-025-00329-5
PG 20
WC Criminology & Penology; Public, Environmental & Occupational Health
WE Emerging Sources Citation Index (ESCI)
SC Criminology & Penology; Public, Environmental & Occupational Health
GA 2CO2W
UT WOS:001479422100001
PM 40304817
OA Green Accepted, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Asthana, NK
   Mehaffey, E
   Sewell, DD
AF Asthana, Niraj K.
   Mehaffey, Eamonn
   Sewell, Daniel D.
TI COVID-19 Associated Suicidal Ideation in Older Adults: Two Case Reports
   With a Review of the Literature
SO AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
LA English
DT Review
DE COVID-19; older adults; case report; mental health; ECT; suicidal
   ideation; social isolation
ID MENTAL-HEALTH; EMOTIONAL RESPONSES; METABOLIC SYNDROME; PERCEIVED
   STRESS; UNITED-STATES; DEPRESSION; IMPACT; LIFE; LONELINESS; PEOPLE
AB The COVID-19 pandemic may profoundly harm the mental health and emotional well-being of many older adults. Public health interventions to minimize the spread of the virus have had the unintended consequences of worsening social isolation, financial stress, and unemployment. Results of early research efforts assessing the impact of these interventions on the mental health of older adults have been mixed. Available findings suggest that a subset of community dwelling older adults have been less negatively impacted than younger adults, while people of color, the poor, residents of nursing homes and other communal living environments, and those living with dementia and their caregivers are more likely to suffer from COVID-related health problems. This manuscript describes two older adults for whom COVID-19 associated stresses caused significant worsening in their psychiatric illnesses, including the emergence of suicidal ideation, summarizes the literature on the impact of interactions between psychosocial stresses and biological factors on the mental health and well-being of older adults, and discusses interventions to help older adults whose mental health has worsened due to COVID-19. Timely and accurate diagnosis, prompt provision of individualized care using both pharmacologic and psychotherapeutic interventions, adoption of new technologies that permit care to be provided safely at a distance and which allow for virtual social interactions, coupled with ongoing advocacy for policy changes that address significant health care disparities and provide older adults continued access to health care and relief from financial hardship, will help older adults remaining as healthy as possible during the pandemic.
C1 [Asthana, Niraj K.; Mehaffey, Eamonn; Sewell, Daniel D.] Univ Calif San Diego, 350 Dickinson St,Suite 221, La Jolla, CA 92093 USA.
C3 University of California System; University of California San Diego
RP Sewell, DD (corresponding author), Univ Calif San Diego, 350 Dickinson St,Suite 221, La Jolla, CA 92093 USA.
EM dsewell@health.ucsd.edu
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NR 80
TC 8
Z9 8
U1 2
U2 20
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1064-7481
EI 1545-7214
J9 AM J GERIAT PSYCHIAT
JI Am. J. Geriatr. Psychiatr.
PD NOV
PY 2021
VL 29
IS 11
BP 1101
EP 1116
DI 10.1016/j.jagp.2021.05.026
EA OCT 2021
PG 16
WC Geriatrics & Gerontology; Gerontology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Psychiatry
GA WF9TE
UT WOS:000706642400006
PM 34266752
OA Green Published
DA 2025-06-11
ER

PT J
AU Gunes, AO
   Caglayan, RHB
   Sen Demirogen, E
   Kose, S
   Ergingoz, E
   Ercan, O
   Alikasifoglu, M
AF Gunes, Asli Okbay
   Caglayan, Rahime Hulya Bingol
   Sen Demirogen, Ezgi
   Kose, Selmin
   Ergingoz, Ethem
   Ercan, Oya
   Alikasifoglu, Mujgan
TI Association Between Depression and Cardiometabolic Risk Factors in
   Adolescents with Obesity
SO MEDICAL JOURNAL OF BAKIRKOY
LA English
DT Article; Proceedings Paper
CT 9th Europaediatrics Congress
CY 2019
CL Dublin, IRELAND
DE Adolescents; cardiometabolic risk factors; degree of obesity; depression
ID OVERWEIGHT; CHILDHOOD; DISORDER; CHILDREN; DISEASE; INDEX
AB Objective: The aim of this study was to examine whether the presence of depression in overweight or obese adolescents increases the likelihood of cardiometabolic risk factors.
   Method: We performed a retrospective cross-sectional analysis of the data obtained from overweight or obese, adolescents aged 11-18 years, who were evaluated in our clinic from January 2012 to December 2015. Depression was evaluated by "Children's Depression Inventory". Hypertension, dyslipidemia, hyperinsulinemia, hyperglycemia and insulin resistance were defined as cardiometabolic risk factors. The degree of obesity was calculated as the body mass index standard deviation score.
   Results: Among 283 adolescents who were included in the study, 75 (26.5%) were overweight, and 208 (73.5%) were obese. The mean age was 14.02 +/- 1.67 years and 168 (59.4%) subjects were girls. The mean body mass index standard deviation score was 2.36 +/- 0.62, The mean Children's Depression Inventory score was 12.72 +/- 6.5, and 47 (16.6%) of the participants were in depression. Depression was more frequently detected in females than in males (p=0.047). Body mass index standard deviation score was in positive correlation with Children's Depression Inventory scores (r=0.123, p= 0.038). In univariate analyses, hyperinsulinemia was found to be 2.3 times more frequent in depressed group than in nondepressed group (p=0.026). In logistic regression analysis this relation disappeared.
   Conclusion: We showed that severity of depression increased, as the degree of obesity increased, but we could not find any clear relationship between depression and cardiometabolic risk factors in overweight or obese adolescents.
C1 [Gunes, Asli Okbay] Istanbul Univ, Cerrahpasa Med Fac, Dept Pediat, Istanbul, Turkey.
   [Caglayan, Rahime Hulya Bingol; Sen Demirogen, Ezgi] Istanbul Univ, Cerrahpasa Med Fac, Dept Child & Adolescent Psychiat, Istanbul, Turkey.
   [Kose, Selmin] Istanbul Bilim Univ, Dept Midwifery, Istanbul, Turkey.
   [Ergingoz, Ethem] Istanbul Univ, Cerrahpasa Med Fac, Dept Publ Hlth, Istanbul, Turkey.
   [Ercan, Oya] Istanbul Univ, Cerrahpasa Med Fac, Dept Pediat, Div Adolescent Med & Endocrinol, Istanbul, Turkey.
   [Alikasifoglu, Mujgan] Istanbul Univ, Cerrahpasa Med Fac, Dept Pediat, Div Adolescent Med, Istanbul, Turkey.
C3 Istanbul University - Cerrahpasa; Istanbul University; Istanbul
   University - Cerrahpasa; Istanbul University; Demiroglu Bilim
   University; Istanbul University; Istanbul University - Cerrahpasa;
   Istanbul University; Istanbul University - Cerrahpasa; Istanbul
   University - Cerrahpasa; Istanbul University
RP Alikasifoglu, M (corresponding author), Istanbul Univ, Cerrahpasa Med Fac, Dept Pediat, Div Adolescent Med, Istanbul, Turkey.
EM kasif@istanbul.edu.tr
RI ERCAN, OYA/IUP-6356-2023; Okbay Güneş, Aslı/ABH-3208-2021; Okbay Gunes,
   Asli/GRF-3734-2022; BINGOL CAGLAYAN, R.HULYA/AAB-1761-2020
OI BINGOL CAGLAYAN, R.HULYA/0000-0002-9414-7147
CR Bundak R, 2013, COCUK ENDOKRINOLOJIS, P21
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   World Health Organization (WHO), Obesity and overweight
NR 33
TC 1
Z9 1
U1 0
U2 7
PU GALENOS YAYINCILIK
PI FINDIKZADE
PA MOLLA GURANI MAHALLESI KACAMAK SOKAK NO 21, FINDIKZADE, ISTANBUL 34093,
   TURKEY
SN 1305-9319
EI 1305-9327
J9 MED J BAKIRKOY
JI Med. J. Bakirkoy
PY 2020
VL 16
IS 4
BP 385
EP 391
DI 10.5222/BMJ.2020.74946
PG 7
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA PU1JK
UT WOS:000609064300013
OA gold
DA 2025-06-11
ER

PT J
AU Dharni, A
   Coates, D
AF Dharni, Aprajita
   Coates, Dominiek
TI Psychotropic medication profile in a community youth mental health
   service in Australia
SO CHILDREN AND YOUTH SERVICES REVIEW
LA English
DT Article
DE Psychotropic medication; Adolescent mental health; Prescribing patterns;
   Antidepressants; Antipsychotics
ID NATIONAL TRENDS; METABOLIC SYNDROME; ANTIPSYCHOTIC USE; CHILDREN;
   ADOLESCENTS; PREVALENCE; EFFICACY; ANTIDEPRESSANTS; DEPRESSION;
   QUETIAPINE
AB Aim: There has been a rise in the use of psychotropic medication in young people, despite limited risk-benefit profile of psychotropic medication for this population. Given their side effect profile, the use of psychotropic medications should occur with caution. This study investigated psychotropic prescribing pattern in a public youth community mental health service and gives an estimate of general level of psychotropic medication use in this setting.
   Methods: A retrospective file review was undertaken of all young people aged 12-17 who received care from the service in 2016 (N = 189) for a range of mental health problems, excluding psychosis. Files were reviewed for demographical information (age, gender), diagnosis/presenting issues, prescribed medications, indications of medications, and prescriber type (e.g. psychiatrist, general practitioners (GPs), paediatrician). The data was analysed descriptively.
   Results: Over 60% (60.8%, n = 115) of young people were prescribed psychotropic medications. Over half of the entire sample were on antidepressants (51.32%, n = 97), nearly a quarter (n = 46, 24%) on antipsychotics, 6% on ADHD medications (6.35%, n = 12), and a fifth (19.58%, n = 37) on polypharmacy. Antidepressants and antipsychotics were mostly used off-label, prescribed by public psychiatric staff. Quetiapine was the most prescribed antipsychotic predominantly for insomnia. Fluoxetine and fluvoxamine were the most prescribed antidepressants predominantly for anxiety disorders. Girls are more likely to be prescribed psychotropic medications than boys, specifically antipsychotic medication.
   Conclusions: A high proportion of young people were prescribed psychotropic medication, including anti psychotic medication, mostly for the treatment of anxiety and depressive disorders. There is little evidence around how psychotropic medication is used in youth mental health settings, and this study contributes to this gap.
C1 [Dharni, Aprajita; Coates, Dominiek] Univ Technol, Fac Hlth, Sydney, NSW, Australia.
C3 University of Technology Sydney
RP Coates, D (corresponding author), Univ Technol Sydney, Level 11,Bldg 10,235 Jones St, Ultimo, NSW 2007, Australia.
EM Dharni.Aprajita@health.nsw.gov.au; Dominiek.Coates@uts.edu.au
OI Coates, Dominiek/0000-0002-4463-7615
CR [Anonymous], 2012, A Guide for Community Child Serving Agencies on Psychotropic Medications for Children and Adolescents
   [Anonymous], 2014, Ethical considerations in quality assurance and evaluation activities
   [Anonymous], GL2007020 NSW HLTH
   [Anonymous], 2005, NICE GUID
   [Anonymous], 2015, National statement on ethical conduct in human research
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NR 59
TC 5
Z9 5
U1 0
U2 6
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0190-7409
EI 1873-7765
J9 CHILD YOUTH SERV REV
JI Child. Youth Serv. Rev.
PD JUL
PY 2018
VL 90
BP 8
EP 14
DI 10.1016/j.childyouth.2018.05.007
PG 7
WC Family Studies; Social Work
WE Social Science Citation Index (SSCI)
SC Family Studies; Social Work
GA GL7GR
UT WOS:000437366100002
DA 2025-06-11
ER

PT J
AU Mattoo, SK
   Singh, SM
AF Mattoo, Surendra K.
   Singh, Shubh Mohan
TI Prevalence of metabolic syndrome in psychiatric inpatients in a tertiary
   care centre in north India
SO INDIAN JOURNAL OF MEDICAL RESEARCH
LA English
DT Article
DE Epidemiology; mental illness; metabolic syndrome; prevalence;
   psychiatric inpatients
ID 3RD NATIONAL-HEALTH; HEART-DISEASE RISK; INSULIN-RESISTANCE; OBESITY;
   SCHIZOPHRENIA; OVERWEIGHT; DEPRESSION; ADULTS
AB Background & objectives: Metabolic syndrome (MS) is associated with major mental illnesses. It is a major predictor of mortality and morbidity. This research was undertaken to study the prevalence and correlates of MS in psychiatric inpatients in a tertiary care hospital in north India.
   Methods: Consecutive adult patients with a primary psychiatric disorder admitted to the psychiatric ward during the study period (July-December 2007) were evaluated for prevalence of MS as per the criteria of the International Diabetes Federation (IDF).
   Results: Among the 90 patients included in the study, the prevalence of MS as per IDF was 37.8 per cent and it was significantly associated with the body mass index (BMI).
   Interpretation & conclusions: The present findings showed a higher prevalence of MS in psychiatric inpatients than that in the general population. Further studies on a larger sample need to be done before advising evaluation for the presence of MS in all psychiatric patients.
C1 [Mattoo, Surendra K.] Postgrad Inst Med Educ & Res, Dept Psychiat, Deaddict Ctr, Chandigarh 160012, India.
C3 Post Graduate Institute of Medical Education & Research (PGIMER),
   Chandigarh
RP Mattoo, SK (corresponding author), Postgrad Inst Med Educ & Res, Dept Psychiat, Deaddict Ctr, Chandigarh 160012, India.
EM skm_ddtc@glide.net.in
OI Singh, Shubh Mohan/0000-0001-8533-6600
CR Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
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NR 28
TC 20
Z9 24
U1 0
U2 5
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, 400059, INDIA
SN 0971-5916
J9 INDIAN J MED RES
JI Indian J. Med. Res.
PD JAN
PY 2010
VL 131
IS 1
BP 46
EP 52
PG 7
WC Immunology; Medicine, General & Internal; Medicine, Research &
   Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; General & Internal Medicine; Research & Experimental
   Medicine
GA 557XV
UT WOS:000274704600008
PM 20167973
DA 2025-06-11
ER

PT J
AU Noce, A
   Di Lauro, M
   Di Daniele, F
   Zaitseva, AP
   Marrone, G
   Borboni, P
   Di Daniele, N
AF Noce, Annalisa
   Di Lauro, Manuela
   Di Daniele, Francesca
   Zaitseva, Anna Pietroboni
   Marrone, Giulia
   Borboni, Patrizia
   Di Daniele, Nicola
TI Natural Bioactive Compounds Useful in Clinical Management of Metabolic
   Syndrome
SO NUTRIENTS
LA English
DT Review
DE metabolic syndrome; natural bioactive compounds; arterial hypertension;
   diabetes mellitus; dyslipidemia; low-grade inflammatory state;
   functional foods
ID RED YEAST RICE; CARDIOMETABOLIC RISK-FACTORS; DOSE-RESPONSE
   METAANALYSIS; RANDOMIZED DOUBLE-BLIND; ESTER TRANSFER PROTEIN; GREEN
   TEA; ADIPOSE-TISSUE; OXIDATIVE STRESS; BLOOD-PRESSURE; GUT MICROBIOTA
AB Metabolic syndrome (MetS) is a clinical manifestation characterized by a plethora of comorbidities, including hyperglycemia, abdominal obesity, arterial hypertension, and dyslipidemia. All MetS comorbidities participate to induce a low-grade inflammation state and oxidative stress, typical of this syndrome. MetS is related to an increased risk of cardiovascular diseases and early death, with an important impact on health-care costs. For its clinic management a poly-pharmaceutical therapy is often required, but this can cause side effects and reduce the patient's compliance. For this reason, finding a valid and alternative therapeutic strategy, natural and free of side effects, could represent a useful tool in the fight the MetS. In this context, the use of functional foods, and the assumption of natural bioactive compounds (NBCs), could exert beneficial effects on body weight, blood pressure and glucose metabolism control, on endothelial damage, on the improvement of lipid profile, on the inflammatory state, and on oxidative stress. This review focuses on the possible beneficial role of NBCs in the prevention and in the clinical management of MetS and its comorbidities.
C1 [Noce, Annalisa; Di Lauro, Manuela; Di Daniele, Francesca; Zaitseva, Anna Pietroboni; Marrone, Giulia; Di Daniele, Nicola] Univ Roma Tor Vergata, UOC Internal Med, Dept Syst Med, Ctr Hypertens, Via Montpellier 1, I-00133 Rome, Italy.
   [Noce, Annalisa; Di Lauro, Manuela; Di Daniele, Francesca; Zaitseva, Anna Pietroboni; Marrone, Giulia; Di Daniele, Nicola] Univ Roma Tor Vergata, Dept Syst Med, Nephrol Unit, Via Montpellier 1, I-00133 Rome, Italy.
   [Di Daniele, Francesca; Marrone, Giulia] Univ Roma Tor Vergata, PhD Sch Appl Med, Surg Sci, Via Montpellier 1, I-00133 Rome, Italy.
   [Borboni, Patrizia] Univ Roma Tor Vergata, Dept Syst Med, Via Montpellier 1, I-00133 Rome, Italy.
C3 University of Rome Tor Vergata; University of Rome Tor Vergata;
   University of Rome Tor Vergata; University of Rome Tor Vergata
RP Noce, A; Marrone, G (corresponding author), Univ Roma Tor Vergata, UOC Internal Med, Dept Syst Med, Ctr Hypertens, Via Montpellier 1, I-00133 Rome, Italy.; Noce, A; Marrone, G (corresponding author), Univ Roma Tor Vergata, Dept Syst Med, Nephrol Unit, Via Montpellier 1, I-00133 Rome, Italy.; Marrone, G (corresponding author), Univ Roma Tor Vergata, PhD Sch Appl Med, Surg Sci, Via Montpellier 1, I-00133 Rome, Italy.
EM annalisa.noce@uniroma2.it; dilauromanuela@gmail.com;
   francesca.didaniele@gmail.com; annapietroboni@icloud.com;
   giul.marr@gmail.com; patrizia.borboni@alice.it;
   didaniele@med.uniroma2.it
RI Noce, Annalisa/B-5558-2019; Di Lauro, Manuela/AAB-9784-2022; Marrone,
   Giulia/IQR-7760-2023
OI Pietroboni Zaitseva, Anna/0000-0001-5407-322X; Marrone,
   Giulia/0000-0002-5854-2086; NOCE, ANNALISA/0000-0003-1310-3730; Di
   Lauro, Manuela/0000-0001-8118-1330
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NR 307
TC 76
Z9 76
U1 0
U2 19
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD FEB
PY 2021
VL 13
IS 2
AR 630
DI 10.3390/nu13020630
PG 33
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA QO1UG
UT WOS:000622931300001
PM 33669163
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Matsunaga, T
   Nishikawa, K
   Adachi, T
   Yasuda, K
AF Matsunaga, Tetsuro
   Nishikawa, Kazutaka
   Adachi, Tetsuya
   Yasuda, Koichiro
TI Associations between dietary consumption and sleep quality in young
   Japanese males
SO SLEEP AND BREATHING
LA English
DT Article
DE Sleep quality; Diet; Mental health; Young Japanese males
ID HISTORY QUESTIONNAIRES; DURATION; INSOMNIA; VALIDITY; ADULTS; HEALTH;
   INDEX; FOOD
AB Purpose Poor sleep quality has been reported to be a risk factor for cardiovascular disease, diabetes, and metabolic syndrome, as well as mental disorders including depression and anxiety. However, few studies have investigated the association between sleep quality and diet in young males. We aimed to assess this association, adjusting for psychological factors. Methods In this study, a total of 124 male Japanese students were analyzed. Sleep quality, diet, and psychological symptoms were assessed using self-reported questionnaires, including the Pittsburgh Sleep Quality Index (PSQI), brief-type self-administered diet history questionnaire (BDHQ), 12-item General Health Questionnaire (GHQ12), and State-Trait Anxiety Inventory (STAI) A-Trait scale. Results Among participants, 40% exhibited a PSQI total score >= 6, indicating poor sleep quality. Poor sleep quality was associated with poor mental health status and higher levels of anxiety. After adjusting for covariates including these psychological factors, poor sleep quality was significantly associated with low intakes of fat, beta-carotene, retinol, alpha-tocopherol, vitamin K, vitamin B-1, daidzein, genistein, and iron. Poor sleep quality was also associated with low intake of pulses, fat and oil, as well as high intakes of sugar-sweetened beverages. Conclusions Our findings demonstrated that sleep quality among young Japanese males was associated with specific dietary features, independently of psychological status, which may help to elucidate the mechanisms underlying the link between sleep and sleep-related diseases.
C1 [Matsunaga, Tetsuro] Mukogawa Womens Univ, Sch Human Environm Sci, Dept Food Sci & Nutr, 6-46 Ikebiraki Cho, Nishinomiya, Hyogo 6638558, Japan.
   [Matsunaga, Tetsuro; Nishikawa, Kazutaka] Naruto Univ Educ, Fac Hlth & Living Sci Educ, Naruto 7728502, Japan.
   [Adachi, Tetsuya] SenriKinran Univ, Fac Human Life Sci, Dept Food & Nutr, Osaka 5650873, Japan.
   [Yasuda, Koichiro] Saiseikai Noe Hosp, Osaka 5360001, Japan.
C3 Mukogawa Women's University; Naruto University of Education
RP Matsunaga, T (corresponding author), Mukogawa Womens Univ, Sch Human Environm Sci, Dept Food Sci & Nutr, 6-46 Ikebiraki Cho, Nishinomiya, Hyogo 6638558, Japan.; Matsunaga, T (corresponding author), Naruto Univ Educ, Fac Hlth & Living Sci Educ, Naruto 7728502, Japan.
EM tmatsunaga-dm@umin.ac.jp
FU JSPS KAKENHI [JP15K01684]
FX This work was supported by JSPS KAKENHI Grant Number JP15K01684.
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NR 28
TC 5
Z9 5
U1 2
U2 8
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1520-9512
EI 1522-1709
J9 SLEEP BREATH
JI Sleep Breath.
PD MAR
PY 2021
VL 25
IS 1
BP 199
EP 206
DI 10.1007/s11325-020-02077-2
EA MAY 2020
PG 8
WC Clinical Neurology; Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Respiratory System
GA RB4PM
UT WOS:000531119800001
PM 32385731
DA 2025-06-11
ER

PT J
AU Ledesma, M
   Hurtado-Roca, Y
   Leon, M
   Giraldo, P
   Pocovi, M
   Civeira, F
   Guallar, E
   Ordovas, JM
   Casasnovas, JA
   Laclaustra, M
AF Ledesma, Marta
   Hurtado-Roca, Yamilee
   Leon, Montserrat
   Giraldo, Pilar
   Pocovi, Miguel
   Civeira, Fernando
   Guallar, Eliseo
   Maria Ordovas, Jose
   Antonio Casasnovas, Jose
   Laclaustra, Martin
TI Association of Ferritin Elevation and Metabolic Syndrome in Males.
   Results from the Aragon Workers' Health Study (AWHS)
SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Article
ID CARDIOVASCULAR RISK-FACTORS; INSULIN-RESISTANCE SYNDROME; KOREAN
   NATIONAL-HEALTH; C-REACTIVE PROTEIN; SERUM FERRITIN; GENERAL-POPULATION;
   OXIDATIVE STRESS; IRON STORES; MEN; INFLAMMATION
AB Context: Ferritin concentration is associated with metabolic syndrome, but the possibility of a nonlinear association has never been explored.
   Objective: This study aimed to examine the relationship between serum ferritin levels and the metabolic syndrome in Spanish adult males.
   Design: This was a cross-sectional analysis of baseline data from the Aragon Workers' Health Study.
   Setting: Healthy workers from a factory were studied during their annual checkup.
   Participants: Spanish male adults (n = 3386) between the ages of 19 and 65 years participated. We excluded participants with ferritin > 500 mu g/L, ferritin < 12 mu g/L, or C-reactive protein > 10 mg/L.
   Main Outcome Measure: Metabolic syndrome was defined according to the 2009 consensus definition from the Joint Interim Statement of several international societies.
   Results: Metabolic syndrome prevalence was 27.1%. We found a positive association between elevated iron stores, measured as serum ferritin concentration, and metabolic syndrome and its criteria. Participants within the highest serum ferritin quintile had a higher risk than those in the lowest quintile for central obesity (odds ratio [OR], 1.88; 95% confidence interval [CI], 1.46-2.42), hypertriglyceridemia (OR, 2.15; 95% CI, 1.69-2.74), and metabolic syndrome (OR, 1.92; 95% CI, 1.48-2.49). The association was nonlinear and occurred at serum ferritin concentrations > 100 mu g/L (similar to 33th percentile). Ferritin was also associated with insulin resistance, measured by homeostatic model assessment-insulin resistance (HOMA-IR) (P trend < .001).
   Conclusions: Our findings suggest that serum ferritin is significantly associated with metabolic syndrome and its criteria (especially central obesity and hypertriglyceridemia), suggesting that ferritin could be an early marker of metabolic damage in the development of metabolic syndrome.
C1 [Ledesma, Marta; Leon, Montserrat; Giraldo, Pilar; Pocovi, Miguel; Civeira, Fernando; Antonio Casasnovas, Jose] Inst Aragones Ciencias Salud, Zaragoza 50009, Spain.
   [Hurtado-Roca, Yamilee; Maria Ordovas, Jose; Laclaustra, Martin] Spanish Natl Ctr Cardiovasc Res, Dept Epidemiogy Atherothrombosis & Imaging, Madrid 28029, Spain.
   [Giraldo, Pilar] CIBERER, Zaragoza 50009, Spain.
   [Guallar, Eliseo] Johns Hopkins Bloomberg Sch Publ Hlth, Welch Ctr Prevent Epidemiol & Clin Res, Dept Epidemiol, Baltimore, MD 21205 USA.
   [Guallar, Eliseo] Johns Hopkins Bloomberg Sch Publ Hlth, Welch Ctr Prevent Epidemiol & Clin Res, Dept Med, Baltimore, MD 21205 USA.
   [Laclaustra, Martin] Univ Autonoma Madrid, Sch Med, Dept Prevent Med & Publ Hlth, Madrid 28029, Spain.
   [Laclaustra, Martin] St Louis Univ, Dept Epidemiol, St Louis, MO 63104 USA.
C3 Centro Nacional de Investigaciones Cardiovasculares (CNIC); CIBER -
   Centro de Investigacion Biomedica en Red; CIBERER; Johns Hopkins
   University; Johns Hopkins Bloomberg School of Public Health; Johns
   Hopkins University; Johns Hopkins Bloomberg School of Public Health;
   Autonomous University of Madrid; Saint Louis University
RP Ledesma, M (corresponding author), Ctr Nacl Invest Cardiovasc, Dept Epidemiogy Atherothrombosis & Imaging, C Melchor Fernandez Almagro 3, Madrid 28029, Spain.
EM mlaclaustra@cnic.es
RI Martínez, J./K-8709-2014; Casasnovas, Jose Antonio/F-4038-2010;
   Laclaustra, Martin/C-6709-2015
OI Casasnovas, Jose Antonio/0000-0002-9887-2629; Laclaustra,
   Martin/0000-0003-3963-0846; HURTADO-ROCA, YAMILEE/0000-0003-1993-6223
FU Instituto Aragones de Ciencias de la Salud (I+CS); Spanish National
   Center for Cardiovascular Research (Centro Nacional de Investigaciones
   Cardiovasculares); Instituto de Salud Carlos III [FIS CP08/00112,
   PI10/00021, PI14/00009]; Peruvian government [088-FINCyT-BDE-2014]; FIS
   [PI12/01703, PI12/01434]
FX The Aragon Workers' Health Study is funded by Instituto Aragones de
   Ciencias de la Salud (I+CS) and the Spanish National Center for
   Cardiovascular Research (Centro Nacional de Investigaciones
   Cardiovasculares). M.La. was supported in part by Grants FIS CP08/00112,
   PI10/00021, and PI14/00009 from the Instituto de Salud Carlos III.
   Y.H.-R. was supported by Scholarship NO. 088-FINCyT-BDE-2014 from the
   Peruvian government. M.P. was supported by FIS PI12/01703. M.Leo. was
   supported by FIS PI12/01434.
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NR 37
TC 17
Z9 18
U1 0
U2 5
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0021-972X
EI 1945-7197
J9 J CLIN ENDOCR METAB
JI J. Clin. Endocrinol. Metab.
PD MAY
PY 2015
VL 100
IS 5
BP 2081
EP 2089
DI 10.1210/jc.2014-4409
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA CM4QG
UT WOS:000357669000065
PM 25695891
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Kar, N
   Barreto, S
AF Kar, Nilamadhab
   Barreto, Socorro
TI Influence of Lifestyle Factors on Metabolic Syndrome in Psychiatric
   Patients Attending a Community Mental Health Setting: A Cross-sectional
   Study
SO INDIAN JOURNAL OF PSYCHOLOGICAL MEDICINE
LA English
DT Article
DE Cardiovascular diseases; diet; exercise; mental disorder; metabolic
   syndrome; quality of life
ID QUALITY-OF-LIFE; SCHIZOPHRENIA-PATIENTS; PREVALENCE; PEOPLE; RISK;
   ANTIPSYCHOTICS; ILLNESS; DEFINITION; DISORDERS; PREDICTORS
AB Background: Metabolic syndrome (MetS) is a concern in psychiatric patients. We aimed to study the influence of the modifiable lifestyle factors on MetS in adult psychiatric patients along with associated clinical factors and quality of life.Methods: Factors such as diet (Healthy Eating Index), exercise, substance use, cardiovascular risk (QRISK), illness severity (Clinical Global Impression), medications, adverse events (Systematic Monitoring of Adverse Events Related to Treatments), and quality of life (Recovering Quality of Life Scale) were assessed along with clinical components for MetS in 323 psychiatric patients receiving routine care and monitoring in a Community Mental Health Team.Results: MetS was present in 50.5% (95% CI: 45.0-55.9). It was significantly associated with higher age, duration of mental illness, body mass index (BMI), QTc, QRISK, and antipsychotic drugs. In logistic regression, age, QTc, QRISK, and BMI remained significantly linked to MetS. Patients with or without MetS were comparable in their lifestyle factors such as diet, exercise, and substance use, along with the family history of metabolic disorders, age at onset of mental illness, duration of antipsychotic medication, side effects, psychiatric diagnoses, and quality of life. However, many patients with or without MetS had poorer diet and physical inactivity, indicating scope for interventions.Conclusions: Around half of the psychiatric patients had MetS, and modifiable lifestyle factors did not differentiate individuals with or without MetS. The need for further research on the prevention and management of MetS in psychiatric patients is highlighted.
C1 [Kar, Nilamadhab] Univ Wolverhampton, Wolverhampton, England.
   [Kar, Nilamadhab; Barreto, Socorro] Black Country Healthcare NHS Fdn Trust, Dept Psychiat, Wolverhampton, England.
   [Kar, Nilamadhab] Black Country Healthcare NHS Fdn Trust, Low Hill, Wolverhampton WV10 9TH, England.
C3 University of Wolverhampton
RP Kar, N (corresponding author), Black Country Healthcare NHS Fdn Trust, Low Hill, Wolverhampton WV10 9TH, England.
EM n.kar@nhs.net
RI ; Kar, Nilamadhab/F-9921-2013
OI Barreto, Socorro/0000-0001-8903-5186; Kar,
   Nilamadhab/0000-0002-8801-9245
FU Research and Innovation Department of the Black Country Healthcare NHS
   Foundation Trust; Institute of Insight, United Kingdom
FX We thank Debbie Lester, Jenny Horne, Dr Faiz Masood, Dr Mahum Kiani, Dr
   Amy Boswell, Dr Helen Wheeldon, Dr Zaib Nisa, Dr Jasmin Mahil, Dr Tulika
   Prasad, Dr Sayyid Ahmed, Dr Sadia Zahid, Dr Susmit Roy, Dr Shreyan Kar,
   Dr Faiz Masood, Dr Thanuja Vidyaratne, Dr Amina Rashid, Dr Brajaballav
   Kar, Dr Nitish Mathur, Alison Grant, Andrew Chapani, Jo Whitehouse, Gaye
   Johnson, for support related to data collection and data quality
   management. We are also thankful to Research and Innovation Department
   of the Black Country Healthcare NHS Foundation Trust and The Institute
   of Insight, United Kingdom.
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NR 75
TC 0
Z9 0
U1 0
U2 2
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0253-7176
EI 0975-1564
J9 INDIAN J PSYCHOL MED
JI Indian J. Psychol. Med.
PD JUL
PY 2024
VL 46
IS 4
BP 313
EP 322
DI 10.1177/02537176231219770
EA JAN 2024
PG 10
WC Psychiatry; Psychology
WE Emerging Sources Citation Index (ESCI)
SC Psychiatry; Psychology
GA ZH3C0
UT WOS:001153549800001
PM 39056040
OA gold
DA 2025-06-11
ER

PT S
AU Straub, RH
AF Straub, Rainer H.
BE Cutolo, M
   Straub, RH
   Masi, AT
   Bijlsma, JWJ
TI Systemic disease sequelae in chronic inflammatory diseases and chronic
   psychological stress: comparison and pathophysiological model
SO STEROIDS IN NEUROENDOCRINE IMMUNOLOGY AND THERAPY OF RHEUMATIC DISEASES
   II
SE Annals of the New York Academy of Sciences
LA English
DT Article; Proceedings Paper
CT 5th International Conference on the Neuroendocrine Immune Basis of the
   Rheumatic Diseases (NEIRD)
CY OCT 01-03, 2013
CL Genoa, ITALY
DE chronic inflammatory disease; rheumatoid arthritis; psychological
   stress; systemic disease sequelae
ID BODY-MASS INDEX; EARLY RHEUMATOID-ARTHRITIS; PITUITARY-ADRENAL AXIS;
   TUMOR-NECROSIS-FACTOR; SYMPATHETIC-NERVE FIBERS;
   GLUCOCORTICOID-RECEPTOR; ENERGY-EXPENDITURE; IN-VITRO; ADRENOCORTICAL
   AXIS; PSYCHOSOCIAL STRESS
AB In chronic inflammatory diseases (CIDs), the neuroendocrine-immune crosstalk is important to allocate energy-rich substrates to the activated immune system. Since the immune system can request energy-rich substrates independent of the rest of the body, I refer to it as the "selfish immune system," an expression that was taken from the theory of the "selfish brain," giving the brain a similar position. In CIDs, the theory predicts the appearance of long-term disease sequelae, such as metabolic syndrome. Since long-standing energy requirements of the immune system determine disease sequelae, the question arose as to whether chronic psychological stress due to chronic activation of the brain causes similar sequelae. Indeed, there are many similarities; however, there are also differences. A major difference is the behavior of body weight (constant in CIDs versus loss or gain in stress). To explain this discrepancy, a new pathophysiological theory is presented that places inflammation and stress axes in the middle.
C1 Univ Hosp Regensburg, Dept Internal Med 1, Lab Expt Rheumatol & Neuroendocrine Immunol, D-93053 Regensburg, Germany.
C3 University of Regensburg
RP Straub, RH (corresponding author), Univ Hosp Regensburg, Dept Internal Med 1, Lab Expt Rheumatol & Neuroendocrine Immunol, BIOPARK 1,Josef Engert Str 9, D-93053 Regensburg, Germany.
EM rainer.straub@ukr.de
OI Straub, Rainer H/0000-0003-1165-4555
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NR 75
TC 8
Z9 9
U1 0
U2 15
PU BLACKWELL SCIENCE PUBL
PI OXFORD
PA OSNEY MEAD, OXFORD OX2 0EL, ENGLAND
SN 0077-8923
J9 ANN NY ACAD SCI
JI Ann.NY Acad.Sci.
PY 2014
VL 1318
BP 7
EP 17
DI 10.1111/nyas.12409
PG 11
WC Endocrinology & Metabolism; Immunology; Rheumatology
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Immunology; Rheumatology
GA BA7XF
UT WOS:000337847000002
PM 24738934
DA 2025-06-11
ER

PT J
AU Brown, MA
   Gellatley, W
   Hoffman, A
   Dowdell, L
   Camac, A
   Francois, R
   Boston, B
   Zekry, A
AF Brown, Mark A.
   Gellatley, Wendy
   Hoffman, Anna
   Dowdell, Lisa
   Camac, Anne
   Francois, Rachel
   Boston, Belinda
   Zekry, Amany
TI Medical complications of homelessness: a neglected side of men's health
SO INTERNAL MEDICINE JOURNAL
LA English
DT Article
DE homelessness; mental health; addiction; cardiovascular disease;
   hepatitis C
ID PEOPLE; SYDNEY; DISORDERS
AB Background: Homelessness is an increasing societal and health issue associated with high rates of substance abuse and mental health disorders. Homeless people die more often and at a younger age than others. Aim: To identify health needs and improve healthcare for homeless men.
   Methods: A physician-led clinic was established on-site at the Mission Australia Centre in Sydney, incorporating: (i) liver screening, including portable fibroscan testing, and on-site treatment of hepatitis C; (ii) a mental health clinic, staffed by a psychiatrist; and (iii) a nurse-led clinic to follow up medical issues and deliver vaccinations. Patient data were recorded prospectively to determine what medical problems were encountered so as to drive future healthcare planning.
   Results: A total of 257 men was assessed between November 2011 and December 2017. In that time, 561 men resided at the Centre. Of these 257 men who attended the clinic, 61% were <45 years old; 69% were current and 8% former smokers; 62% had a history of chronic alcoholic abuse and 66% other substance abuse; 64% had one or more of depression, anxiety, psychosis or another mental health disorder and 44% had metabolic syndrome features, 38% cardiovascular disease, 29% hepatitis C and 21% a respiratory disorder.
   Conclusion: The main health needs of homeless men fall into the categories of mental health; cardiovascular, respiratory and metabolic disorders and addictions and hepatitis C. Establishing on-site clinics at homeless shelters with expertise to address these issues will likely improve the well-being of these men, reduce hospital admissions and prolong their lives.
C1 [Brown, Mark A.; Hoffman, Anna; Camac, Anne] St George Hosp, Dept Renal Med, Sydney, NSW, Australia.
   [Dowdell, Lisa; Zekry, Amany] St George Hosp, Dept Gastroenterol, Sydney, NSW, Australia.
   [Boston, Belinda] St George Hosp, Dept Infect Control, Sydney, NSW, Australia.
   [Brown, Mark A.; Zekry, Amany] Univ NSW, Sydney, NSW, Australia.
   [Gellatley, Wendy] Optimus Clin Res, Sydney, NSW, Australia.
   [Francois, Rachel] Mission Australia Ctr, Sydney, NSW, Australia.
C3 St George Hospital; St George Hospital; St George Hospital; University
   of New South Wales Sydney; Optimus Clinical Research
RP Brown, MA (corresponding author), St George Hosp, Dept Renal Med, Kogarah, NSW 2217, Australia.
EM mark.brown1@health.nsw.gov.au
RI Richard, François/HJA-3350-2022; zekry, amany/ABC-9995-2020
OI Brown, Mark/0000-0002-4759-9407; ZEKRY, AMANY/0000-0002-5675-1810
CR Babidge NC, 2001, ACTA PSYCHIAT SCAND, V103, P105, DOI 10.1034/j.1600-0447.2001.00192.x
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NR 16
TC 13
Z9 16
U1 0
U2 10
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1444-0903
EI 1445-5994
J9 INTERN MED J
JI Intern. Med. J.
PD APR
PY 2019
VL 49
IS 4
BP 455
EP 460
DI 10.1111/imj.14139
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA HW1BX
UT WOS:000466418500006
PM 30324639
DA 2025-06-11
ER

PT J
AU Kerkadi, A
   Alkudsi, DS
   Hamad, S
   Alkeldi, HM
   Salih, R
   Agouni, A
AF Kerkadi, Abdelhamid
   Alkudsi, Dana Samir
   Hamad, Sara
   Alkeldi, Hanan Mohamed
   Salih, Reem
   Agouni, Abdelali
TI The Association between Zinc and Copper Circulating Levels and
   Cardiometabolic Risk Factors in Adults: A Study of Qatar Biobank Data
SO NUTRIENTS
LA English
DT Article
DE Qatar Biobank; zinc; copper; Zn; Cu ratio; cardiometabolic risk;
   metabolic syndrome; adults
ID CORONARY-HEART-DISEASE; SERUM ZINC; CARDIOVASCULAR-DISEASE;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; DIABETES-MELLITUS; OXIDATIVE
   STRESS; FASTING GLUCOSE; TRACE-ELEMENTS; FATTY-ACIDS
AB Cardiometabolic risk (CMR) factors increase the likelihood of developing cardiovascular diseases (CVD). In Qatar, 24% of the total deaths are attributed to CVDs. Several nutritional disturbances have been linked to high risk of CVD. Many studies have discussed the effects of zinc (Zn) and copper (Cu) on CMR factors; however, evidence has been controversial. This investigated the association between CMR factors and the status of Zn and Cu, in addition to Zn/Cu ratio. A total of 575 Qatari men and women aged 18 years and older were obtained from Qatar Biobank. Plasma levels of Zn and Cu were determined using inductively coupled plasma mass spectrometry (ICP-MS). Anthropometric data and CMR factors were determined using standard methods. Adjusted associations between trace minerals and CMR were estimated by logistic regression. Partial correlation was performed to test the strength of the associations. Zn was not strongly correlated (p-value > 0.01) or significantly associated with CMR factors and metabolic syndrome (MetS). Cu levels correlated positively with body mass index (BMI) (0.23; p < 0.001), pulse rate (PR) (0.18; p < 0.001), total cholesterol (0.13; p = 0.01), and high-density lipoproteins (HDL) (0.27; p < 0.001); and negatively with diastolic blood pressure (DBP) (-0.13; p = 0.01). High plasma Cu significantly decreased the risk of metabolic syndrome (MetS) (0.121; p < 0.001). Furthermore, Zn/Cu ratio positively correlated with waist circumference (0.13; p = 0.01), systolic blood pressure (0.13; p < 0.01), and DBP (0.14; p < 0.01); and negatively with BMI (-0.19; p < 0.001), PR (-0.17; p < 0.001), and HDL (-0.27; p < 0.001). High Zn/Cu ratio increased the prevalence of low HDL (4.508; p < 0.001) and MetS (5.570; p < 0.01). These findings suggest that high plasma Cu levels are associated with a protective effect on DBP, HDL and MetS and that high plasma Zn/Cu ratio is associated with the risk of having low HDL and MetS.
C1 [Kerkadi, Abdelhamid; Alkudsi, Dana Samir; Hamad, Sara; Alkeldi, Hanan Mohamed; Salih, Reem] Qatar Univ, Dept Human Nutr, Coll Hlth Sci, QU Hlth, POB 2713, Doha, Qatar.
   [Agouni, Abdelali] Qatar Univ, Dept Pharmaceut Sci, Coll Pharm, QU Hlth, POB 2713, Doha, Qatar.
   [Agouni, Abdelali] Qatar Univ, Biomed & Pharmaceut Res Unit BPRU, QU Hlth, POB 2713, Doha, Qatar.
C3 Qatar University; Qatar University; Qatar University
RP Kerkadi, A (corresponding author), Qatar Univ, Dept Human Nutr, Coll Hlth Sci, QU Hlth, POB 2713, Doha, Qatar.
EM abdel.hamid@qu.edu.qa; da1701633@qu.edu.qa; sh1604803@qu.edu.qa;
   ha1608292@qu.edu.qa; rsalih@qu.edu.qa; aagouni@qu.edu.qa
RI kerkadi, Abdelhamid/E-1475-2018; Agouni, Abdelali/AAP-5298-2020
OI kerkadi, abdelhamid/0000-0003-4078-1406; Agouni,
   Abdelali/0000-0002-8363-1582
FU Qatar University Research Support Office [QUST-2-CHS-2020-16]
FX This study was supported by grant QUST-2-CHS-2020-16 from Qatar
   University Research Support Office.
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NR 115
TC 13
Z9 13
U1 0
U2 7
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD AUG
PY 2021
VL 13
IS 8
AR 2729
DI 10.3390/nu13082729
PG 16
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA UH2GR
UT WOS:000689756900001
PM 34444889
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Booth, AO
   Wang, XD
   Turner, AI
   Nowson, CA
   Torres, SJ
AF Booth, Alison O.
   Wang, Xiaodan
   Turner, Anne I.
   Nowson, Caryl A.
   Torres, Susan J.
TI Diet-Induced Weight Loss Has No Effect on Psychological Stress in
   Overweight and Obese Adults: A Meta-Analysis of Randomized Controlled
   Trials
SO NUTRIENTS
LA English
DT Article
DE diet; weight loss; obesity; stress; adults; meta-analysis
ID QUALITY-OF-LIFE; BODY-WEIGHT; METABOLIC SYNDROME; BEHAVIOR; RISK;
   PERFORMANCE; RESPONSES; WORKLOAD; DISEASE; PROFILE
AB The effect of weight loss on psychological stress is unknown. The study aimed to investigate the effect of diet-induced weight loss in overweight and obese adults on psychological measures of stress through a meta-analysis of randomized controlled trials (RCTs). Databases including Medline Complete, Embase and PsycINFO were searched up to February 2018 for diet-induced weight loss RCTs, which included self-reported assessment of psychological stress. The mean difference between the intervention and control group of changes in stress (interventionbaseline) was used. Ten RCTs were included with 615 participants (502 women, age range 20-80 years). Overall, there was no change in stress (mean difference -0.06, 95% CI: -0.17, 0.06, p = 0.33) and no change in the five studies with a significant reduction in weight in the intervention group compared to a control group that lost no weight (mean difference in weight -3.9 Kg, 95% CI: -5.51, -2.29, p < 0.0001; mean difference in stress 0.04, 95% CI: -0.17, 0.25, p = 0.71). For all analyses, there was low heterogeneity. The benefits of weight loss for those who are overweight and obese do not appear to either increase or reduce psychological stress at the end of the weight loss period.
C1 [Booth, Alison O.; Wang, Xiaodan; Turner, Anne I.; Nowson, Caryl A.; Torres, Susan J.] Deakin Univ, Inst Phys Act & Nutr, Sch Exercise & Nutr Sci, Geelong, Vic 3220, Australia.
C3 Deakin University
RP Torres, SJ (corresponding author), Deakin Univ, Inst Phys Act & Nutr, Sch Exercise & Nutr Sci, Geelong, Vic 3220, Australia.
EM alison.booth@deakin.edu.au; swang17@gmail.com;
   anne.turner@deakin.edu.au; caryl.nowson@deakin.edu.au;
   susan.torres@deakin.edu.au
RI Turner, Anne/ACH-8306-2022
OI Turner, Anne/0000-0002-0682-2860; Nowson, Caryl/0000-0001-6586-7965;
   Torres, Susan/0000-0002-2599-1934
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NR 48
TC 7
Z9 9
U1 0
U2 11
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD MAY
PY 2018
VL 10
IS 5
AR 613
DI 10.3390/nu10050613
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nutrition & Dietetics
GA GJ3LI
UT WOS:000435196000087
PM 29757978
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Cloete, SA
   Daniels, FM
AF Cloete, Shoemeney A.
   Daniels, Felicity M.
TI Perceptions of Mental Health Nurses Regarding Metabolic Syndrome at a
   Public Tertiary Psychiatric Hospital in Western Cape, South Africa
SO AFRICAN JOURNAL OF NURSING AND MIDWIFERY
LA English
DT Article
DE mental health; metabolic syndrome; severe mental illness; specialised
   mental health nurse; professional nurse
ID NONCOMMUNICABLE DISEASES; PREVALENCE; PEOPLE; RISK; CARE; ATTITUDES;
   ILLNESS
AB Mental and physical health should not be regarded as two separate entities. Recognising the periodic co-morbidity between mental and physical health conditions could facilitate an improvement in the observed lack of screening for metabolic syndrome (MetS) in patients with severe mental illness (SMI). The aim of the current study was to investigate the perceptions of mental health nurses about their knowledge, attitudes and practices regarding mental health care users (MCHUs) with MetS in a public tertiary psychiatric hospital. The study was conducted in one of the four public, tertiary psychiatric hospitals in Western Cape, South Africa. A self-administered quantitative descriptive survey design, using an 18-item modified version of the MBACK-Questionnaire was conducted with an all-inclusive sample of 97 mental health nurses. Ethics approval was obtained from the Western Cape Department of Health and the Research Ethics Committee from the University of Western Cape. A response rate of 87.6% (n = 85) was attained. The specialised mental health nurses reported perceived higher knowledge scores than the non-specialised mental health nurses, with no significant differences between the responses of their level of agreement for their attitudes and self-reported practices on the topic. The specialised mental health nurses perceived themselves to have better knowledge than the non-specialised mental health nurses, with both categories exhibiting similar positive attitudes towards providing general physical care and active involvement in their practice towards mental health care users (MHCUs) with MetS.
C1 [Cloete, Shoemeney A.; Daniels, Felicity M.] Univ Western Cape, Bellville, South Africa.
C3 University of the Western Cape
RP Cloete, SA (corresponding author), Univ Western Cape, Bellville, South Africa.
EM 3770003@myuwc.ac.za; fdaniels@uwc.ac.za
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NR 36
TC 0
Z9 0
U1 0
U2 0
PU UNISA PRESS
PI PRETORIA
PA PO BOX 392, PRETORIA, 0003, SOUTH AFRICA
SN 1682-5055
J9 AFR J NURS MIDWIFERY
JI Afr. J. Nurs. Midwifery
PY 2022
VL 24
IS 1
AR 9469
DI 10.25159/2520-5293/9469
PG 13
WC Nursing
WE Emerging Sources Citation Index (ESCI)
SC Nursing
GA F1RY1
UT WOS:000980200400011
OA Bronze
DA 2025-06-11
ER

PT J
AU Sasaki, A
   de Vega, W
   Sivanathan, S
   St-Cyr, S
   McGowan, PO
AF Sasaki, A.
   de Vega, W.
   Sivanathan, S.
   St-Cyr, S.
   McGowan, P. O.
TI MATERNAL HIGH-FAT DIET ALTERS ANXIETY BEHAVIOR AND GLUCOCORTICOID
   SIGNALING IN ADOLESCENT OFFSPRING
SO NEUROSCIENCE
LA English
DT Article
DE glucocorticoid receptor; inflammatory; anxiety behavior; maternal;
   obesity; gene expression programming
ID MECHANISMS LINKING OBESITY; PITUITARY-ADRENAL AXIS; FEMALE RATS;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; STRESS RESPONSES; PRENATAL
   STRESS; MILD STRESS; PREGNANCY; ADULTHOOD
AB Maternal obesity and overconsumption of saturated fats during pregnancy have profound effects on offspring health, ranging from metabolic to behavioral disorders in later life. The influence of high-fat diet (HFD) exposure on the development of brain regions implicated in anxiety behavior is not well understood. We previously found that maternal HFD exposure is associated with an increase in anxiety behavior and alterations in the expression of several genes involved in inflammation via the glucocorticoid signaling pathway in adult rat offspring. During adolescence, the maturation of feedback systems mediating corticosteroid sensitivity is incomplete, and therefore distinct from adulthood. In this study, we examined the influence of maternal HFD on several measures of anxiety behavior and gene expression in adolescent offspring. We examined the expression of corticosteroid receptors and related inflammatory processes, as corticosteroid receptors are known to regulate circulating corticosterone levels during basal and stress conditions in addition to influencing inflammatory processes in the hippocampus and amygdala. We found that adolescent animals perinatally exposed to HFD generally showed decreased anxiety behavior accompanied by a selective alteration in the expression of the glucocorticoid receptor and several downstream inflammatory genes in the hippocampus and amygdala. These data suggest that adolescence constitutes an additional period when the effects of developmental programming may modify mental health trajectories. (C) 2014 IBRO. Published by Elsevier Ltd. All rights reserved.
C1 Univ Toronto, Dept Biol Sci, Ctr Environm Epigenet & Dev, Toronto, ON M1C 1A4, Canada.
   Univ Toronto, Dept Cell & Syst Biol, Toronto, ON M1C 1A4, Canada.
C3 University of Toronto; University of Toronto
RP McGowan, PO (corresponding author), Univ Toronto, Dept Biol Sci, Room SW548,1265 Mil Trail, Toronto, ON M1C 1A4, Canada.
EM patrick.mcgowan@utoronto.ca
FU Natural Sciences and Engineering Research Council of Canada (NSERC)
FX This work was supported by an operating grant from the Natural Sciences
   and Engineering Research Council of Canada (NSERC) to P.O.M.
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NR 56
TC 89
Z9 104
U1 1
U2 27
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4522
EI 1873-7544
J9 NEUROSCIENCE
JI Neuroscience
PD JUL 11
PY 2014
VL 272
BP 92
EP 101
DI 10.1016/j.neuroscience.2014.04.012
PG 10
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA AJ0IY
UT WOS:000337335400010
PM 24791714
DA 2025-06-11
ER

PT J
AU Mayolas-Pi, C
   Sitko, S
   Oviedo-Caro, MA
   Bueno-Antequera, J
   Reverter-Masià, J
   Francín-Gallego, M
   Sarasa-Oliván, FJ
   Legaz-Arrese, A
AF Mayolas-Pi, C.
   Sitko, S.
   Oviedo-Caro, M. A.
   Bueno-Antequera, J.
   Reverter-Masia, J.
   Francin-Gallego, M.
   Sarasa-Olivan, F. J.
   Legaz-Arrese, A.
TI Influence of organised sports practice during adolescence on health of
   adult women with special emphasis on participation in aesthetic sports
SO EUROPEAN JOURNAL OF SPORT SCIENCE
LA English
DT Article
DE Physical activity; aesthetic sports; psychosocial health; quality of
   life; cardiometabolic risk
ID PHYSICAL-ACTIVITY; BODY DISSATISFACTION; SLEEP; DEPRESSION; CHILDHOOD;
   ASSOCIATIONS; RELIABILITY; PERFORMANCE; PREVALENCE; VALIDATION
AB This study aimed to assess the differences in psychosocial health and cardiometabolic risk during adulthood in women based on previously organised sport (OS) participation during adolescence and current activity levels, with emphasis on participation in aesthetic sports. The study included 1947 women aged 18-55 years who were categorised into four groups: 355 aesthetic athletes during adolescence, 494 non- aesthetic athletes during adolescence, 791 non-athletes during adolescence with similar current levels of physical activity (PA) to OS groups and 307 currently inactive non-athletes during adolescence. Participants answered questionnaires regarding sport participation, psychosocial health and cardiometabolic risk. The results show that non-athletes during adolescence who are currently inactive reported significantly lower psychosocial health and higher cardiometabolic risk scores. Women with currently homogenous PA levels (chi(2) = 0.514) reported similar physical quality of life (QoL), exercise addiction, anxiety and depression symptoms regardless of participation in OS during adolescence (P > .05), except aesthetic athletes who reported the worst sleep and mental QoL. Very high training volumes in aesthetic athletes did not influence psychological outcomes and cardiometabolic risk in adulthood compared to lower training volumes. In conclusion, the effects of PA during adulthood appear to be powerful enough to induce beneficial adaptations in health outcomes that match those observed in women who participate in OS during adolescence, except for aesthetic sports participants, who show a high risk of lower quality of sleep in adulthood. PA should be promoted in adults and especially women who have not participated in OS during adolescence.
C1 [Mayolas-Pi, C.; Legaz-Arrese, A.] Univ Zaragoza, Fac Hlth & Sport Sci, Sect Phys Educ & Sports, Zaragoza, Spain.
   [Mayolas-Pi, C.; Sitko, S.; Legaz-Arrese, A.] Univ Zaragoza, Fac Hlth & Sport Sci, Zaragoza, Spain.
   [Mayolas-Pi, C.; Sitko, S.; Oviedo-Caro, M. A.; Bueno-Antequera, J.; Reverter-Masia, J.; Francin-Gallego, M.; Sarasa-Olivan, F. J.; Legaz-Arrese, A.] Univ Zaragoza, Res Grp Movimiento Humano, Zaragoza, Spain.
   [Oviedo-Caro, M. A.; Bueno-Antequera, J.] Univ Pablo de Olavide, Fac Sports Sci, Phys Performance & Sports Res Ctr, Dept Sports & Comp Sci,Sect Phys Educ & Sports, Seville, Spain.
   [Reverter-Masia, J.] Univ Lleida, Sect Phys Educ & Sports, Fac Educ Psychol & Social Work, Lleida, Spain.
   [Francin-Gallego, M.] Univ San Jorge, Hlth Sci Fac, Campus Univ Villanueva de Gallego, Villanueva De Gallego, Spain.
   [Sarasa-Olivan, F. J.] Med Ctr Sports Med, Podium, Zaragoza, Spain.
C3 University of Zaragoza; University of Zaragoza; University of Zaragoza;
   Universidad Pablo de Olavide; Universitat de Lleida; Universidad San
   Jorge
RP Sitko, S (corresponding author), Univ Zaragoza, Calle Domingo Miral S-N, E-50009 Zaragoza, Spain.
EM 685492@unizar.es
RI Reverter-Masia, Joaquin/H-5725-2012; Mayolas-Pi, Carmen/Y-2652-2018;
   Oviedo-Caro, Miguel/AAT-6933-2020; Sitko, Sebastian/AAD-6806-2020;
   Bueno-Antequera, Javier/H-5515-2015
OI Mayolas Pi, Carmen/0000-0003-0721-2447; FRANCIN GALLEGO,
   MARINA/0000-0001-9139-5834; Oviedo-Caro, Miguel
   Angel/0000-0003-1032-0529; Bueno-Antequera, Javier/0000-0001-8063-3980
FU University of Zaragoza, Spain [UZ2016-BIO-03]; Government of Aragon
   through the European Fund of Regional Development-Operative program
   FEDER Aragon 2014-2020 "Construyendo Europa desde Aragon" [S25-D17,
   PUI/2018337, PUI/2018-336]; Spanish Ministry of Education [FPU13/05130];
   Universidad de Lleida, Catedra ASISA [X18010]
FX This work was supported by the University of Zaragoza, Spain (Grant
   Number UZ2016-BIO-03), and the Government of Aragon (Grant Number
   S25-D17) through the European Fund of Regional Development-Operative
   program FEDER Aragon 2014-2020 "Construyendo Europa desde Aragon". JBA
   was supported by the Spanish Ministry of Education (Grant Number
   FPU13/05130). JBA and MAOC were supported by the Government of Aragon
   through the European Fund of Regional Development-Operative program
   FEDER Aragon 2014-2020 "Construyendo Europa desde Aragon" (grant numbers
   PUI/2018337 (JBA) and PUI/2018-336 (MAOC)). JRM was supported by
   Universidad de Lleida, Catedra ASISA (Grant Number X18010).
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NR 42
TC 5
Z9 5
U1 4
U2 26
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1746-1391
EI 1536-7290
J9 EUR J SPORT SCI
JI Eur. J. Sport Sci.
PD JAN 2
PY 2021
VL 21
IS 1
BP 107
EP 117
DI 10.1080/17461391.2020.1736180
EA MAR 2020
PG 11
WC Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Sport Sciences
GA PS8CK
UT WOS:000524702300001
PM 32101509
DA 2025-06-11
ER

PT J
AU Goldman, N
   Glei, DA
   Seplaki, C
   Liu, IW
   Weinstein, M
AF Goldman, N
   Glei, DA
   Seplaki, C
   Liu, IW
   Weinstein, M
TI Perceived stress and physiological dysregulation in older adults
SO STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS
LA English
DT Article
DE aging; allostatic load; biomarkers; perceived stress; physiological
   dysregulation; physiological parameters
ID METABOLIC SYNDROME-X; ALLOSTATIC LOAD; BLOOD-PRESSURE;
   DEHYDROEPIANDROSTERONE-SULFATE; SEX-DIFFERENCES; CARDIOVASCULAR-DISEASE;
   PSYCHOLOGICAL STRESS; RISK-FACTORS; LIFE EVENTS; HEALTH
AB We use a population-based representative sample of older Taiwanese to investigate links between respondents' perceived levels of stress and a broad set of biological measures. These biomarkers were collected at a single time (2000) and reflect sympathetic nervous system (SNS)-activity, hypothalamo-pituitary-adrenal (HPA)-activity, immune function, cardiovascular function, and metabolic pathways. We model the relationship between perceived stress and (1) extreme values for each of 16 individual biological indicators; and (2) a measure of cumulative physiological dysregulation based on the full set of biomarkers. We consider two measures of perceived stress, one derived from the 2000 interview and the second based on data from three interviews (1996-2000). Age and sex-adjusted models reveal significant associations between measures of perceived stress and extreme values of cortisol, triglycerides, interleukin-6 (IL-6), dehydroepiandrosterone sulphate (DHEAS) and fasting glucose. Examined individually, numerous biomarkers, including those pertaining to blood pressure and obesity, are not significantly related to perceived stress. jointly, however, the measure of cumulative physiological clysregulation is associated with both the level of perceived stress at a given time and to a longitudinal measure of perceived stress. Some results suggest that the relationship between level of perceived stress and physiological response is stronger for women than men.
C1 Princeton Univ, Off Populat Res, Princeton, NJ 08540 USA.
   Univ Calif Berkeley, Dept Demog, Berkeley, CA 94720 USA.
   Bur Hlth Promot, Dept Hlth, Ctr Populat & Hlth Survey Res, Taichung 408, Taiwan.
   Georgetown Univ, Ctr Populat Hlth, Washington, DC 20057 USA.
C3 Princeton University; University of California System; University of
   California Berkeley; Georgetown University
RP Goldman, N (corresponding author), Princeton Univ, Off Populat Res, 243 Wallace Hall, Princeton, NJ 08544 USA.
EM ngoldman@princeton.edu
OI Goldman, Noreen/0000-0003-2865-9491; Seplaki,
   Christopher/0000-0001-8296-7714
FU NIA NIH HHS [R01AG16661, R01AG16790] Funding Source: Medline; NICHD NIH
   HHS [5P30HD32030] Funding Source: Medline
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NR 54
TC 79
Z9 106
U1 1
U2 30
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 1025-3890
J9 STRESS
JI Stress
PD JUN
PY 2005
VL 8
IS 2
BP 95
EP 105
DI 10.1080/10253890500141905
PG 11
WC Behavioral Sciences; Endocrinology & Metabolism; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Behavioral Sciences; Endocrinology & Metabolism; Neurosciences &
   Neurology
GA 946OU
UT WOS:000230582600002
PM 16019601
OA Bronze
DA 2025-06-11
ER

PT J
AU McIntyre, RS
   Fayyad, R
   Mackell, JA
   Boucher, M
AF McIntyre, Roger S.
   Fayyad, Rana
   Mackell, Joan A.
   Boucher, Matthieu
TI Effect of metabolic syndrome and thyroid hormone on efficacy of
   desvenlafaxine 50 and 100 mg/d in major depressive disorder
SO CURRENT MEDICAL RESEARCH AND OPINION
LA English
DT Article
DE metabolic syndrome X; thyroid-stimulating hormone; comorbidity; body
   mass index; HDL cholesterol; depression; Blood pressure
ID PRETREATMENT ORTHOSTATIC HYPOTENSION; PLACEBO-CONTROLLED TRIAL;
   DOUBLE-BLIND; TREATMENT RESPONSE; GERIATRIC DEPRESSION;
   SERUM-CHOLESTEROL; BLOOD-PRESSURE; SAFETY; TOLERABILITY; SYMPTOMS
AB Objective This pooled, post hoc analysis evaluated the efficacy of desvenlafaxine vs placebo in adults with major depressive disorder (MDD) with and without metabolic syndrome, and above or at or below median baseline thyroid-stimulating hormone (TSH) levels.
   Research design and methods Patients were randomly assigned to receive desvenlafaxine 50 or 100 mg/d or placebo in nine short-term, double-blind studies. Metabolic syndrome was defined as meeting at least three of five criteria based on body mass index, triglycerides, high-density lipoprotein, fasting glucose, blood pressure, current medication, and medical history.
   Clinical trial registration NCT00072774; NCT00277823; NCT00300378; NCT00384033; NCT00798707; NCT00863798; NCT01121484; NCT00824291; NCT01432457
   Main outcome measures Treatment effects on change from baseline in 17-item Hamilton Rating Scale for Depression (HAM-D-17) total score at week 8 (last observation carried forward [LOCF]) were analyzed in four subgroups-metabolic syndrome and no metabolic syndrome, baseline TSH levels above median or at or below median-using analysis of covariance with treatment, study, and baseline in the model. Metabolic syndrome and TSH were examined as predictors of change in HAM-D-17 total score using regression analysis.
   Results The pooled analysis included 4279 patients; 971 (22.7%) patients had metabolic syndrome. In all subgroups, HAM-D-17 total scores improved significantly from baseline to week 8 (LOCF) with desvenlafaxine 50 or 100 mg/d compared with placebo (all p <= 0.006). There was no significant treatment by metabolic syndrome or by TSH interaction. Neither metabolic syndrome nor TSH above median predicted change in HAM-D-17 total scores, response (>= 50% reduction in HAM-D-17 total score), or remission (HAM-D-17 total score <= 7; all p > 0.05).
   Limitations Individual studies included in this analysis were not designed to examine the relationship between metabolic syndrome or TSH and response to desvenlafaxine treatment. Metabolic syndrome status was determined post hoc based on available baseline measures and not diagnosed at study entry. Exclusion criteria were selected to enroll medically healthy patients with a primary diagnosis of MDD (i.e., patients healthier than the general MDD population).
   Conclusions Desvenlafaxine 50 and 100 mg/d significantly improved depression compared with placebo in patients with and without metabolic syndrome, and in patients with baseline TSH above median and at or below median levels.
C1 [McIntyre, Roger S.] Univ Toronto, Toronto, ON M5T 2S8, Canada.
   [Fayyad, Rana; Mackell, Joan A.] Pfizer Inc, New York, NY USA.
   [Boucher, Matthieu] Pfizer Canada, Kirkland, PQ, Canada.
C3 University of Toronto; Pfizer; Pfizer USA; Pfizer; Pfizer Canada
RP McIntyre, RS (corresponding author), Univ Toronto, Psychiat & Pharmacol, 399 Bathurst St,MP 9-325, Toronto, ON M5T 2S8, Canada.; McIntyre, RS (corresponding author), Univ Hlth Network, Mood Disorders Psychopharmacol Unit, 399 Bathurst St,MP 9-325, Toronto, ON M5T 2S8, Canada.; Boucher, M (corresponding author), Pfizer Canada Inc, Med Affairs, 17300 Transcanada Highway, Kirkland, PQ H9J 2M5, Canada.
EM roger.mcintyre@uhn.ca; matthieu.boucher@pfizer.com
RI McIntyre, Roger/AAU-1000-2020; Boucher, Matthieu/AAV-2538-2021
OI Boucher, Matthieu/0000-0002-4066-0009
FU Pfizer Inc.
FX This study was sponsored by Pfizer Inc.
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NR 61
TC 4
Z9 4
U1 0
U2 3
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0300-7995
EI 1473-4877
J9 CURR MED RES OPIN
JI Curr. Med. Res. Opin.
PD MAR 3
PY 2016
VL 32
IS 3
BP 587
EP 599
DI 10.1185/03007995.2015.1136603
PG 13
WC Medicine, General & Internal; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Research & Experimental Medicine
GA DE2JM
UT WOS:000370453600001
PM 26709542
DA 2025-06-11
ER

PT J
AU Elgellaie, A
   Thomas, SJ
   Kaelle, J
   Bartschi, J
   Larkin, T
AF Elgellaie, Asmahan
   Thomas, Susan J. J.
   Kaelle, Jacqueline
   Bartschi, Jessica
   Larkin, Theresa
TI Pro-inflammatory cytokines IL-1α, IL-6 and TNF-α in major depressive
   disorder: Sex-specific associations with psychological symptoms
SO EUROPEAN JOURNAL OF NEUROSCIENCE
LA English
DT Article
DE cardiometabolic disease; interleukin 1 alpha; interleukin 6; major
   depressive disorder; psychological distress; tumour necrosis factor
   alpha
ID NECROSIS-FACTOR-ALPHA; STRESS SCALES DASS; CARDIOVASCULAR-DISEASE;
   TREATMENT RESPONSE; METABOLIC SYNDROME; IMMUNE-SYSTEM; METAANALYSIS;
   HOSTILITY; ANXIETY; MARKERS
AB The pro-inflammatory cytokines IL-1 alpha, IL-6 and TNF-alpha are associated with major depressive disorder, psychological distress, cardiovascular health and obesity. However, there is limited research that has examined multiple associations between these variables, particularly among individuals with major depressive disorder who are treatment free, in comparison with a control cohort, and including analyses of sex differences. In this study, data were analysed from 60 individuals with major depressive disorder and 60 controls, including plasma IL-1 alpha, IL-6 and TNF-alpha, adiposity measures (body mass index, waist circumference), cardiovascular health indices (blood pressure, heart rate) and psychological symptoms (depressive severity, anxiety, hostility, stress). The cytokines were compared by group and sex and correlated with measures of adiposity, cardiovascular health indices and psychological health. Plasma IL-1 alpha and IL-6 were higher in major depressive disorder group versus control, but with a sex interaction for IL-6, with this group difference only among females. TNF-alpha did not differ between groups. IL-1 alpha and IL-6 correlated with depressive severity, anxiety, hostility and stress, whereas TNF-alpha correlated only with anxiety and hostility. Psychopathology was associated with IL-1 alpha in males only and with IL-6 and TNF-alpha in females only. None of the cytokines correlated with body mass index, waist circumference, blood pressure or heart rate. The result of group by sex interaction for IL-6 and sex-specific associations between pro-inflammatory cytokines and psychometrics could be aetiologically important in depression interventions and treatments for females versus males, warranting further investigation.
C1 [Elgellaie, Asmahan; Thomas, Susan J. J.; Kaelle, Jacqueline; Bartschi, Jessica; Larkin, Theresa] Univ Wollongong, Fac Sci Med & Hlth, Grad Sch Med, Wollongong, NSW 2522, Australia.
   [Elgellaie, Asmahan; Thomas, Susan J. J.; Kaelle, Jacqueline; Bartschi, Jessica; Larkin, Theresa] Illawarra Hlth & Med Res Inst, Wollongong, NSW, Australia.
   [Kaelle, Jacqueline] Illawarra Community Mental Hlth, Wollongong, NSW, Australia.
   [Bartschi, Jessica] Univ Wollongong, Fac Arts Social Sci & Humanities, Sch Psychol, Wollongong, NSW, Australia.
C3 University of Wollongong; University of Wollongong; Illawarra Health &
   Medical Research Institute; University of Wollongong
RP Elgellaie, A (corresponding author), Univ Wollongong, Fac Sci Med & Hlth, Grad Sch Med, Wollongong, NSW 2522, Australia.
EM aae854@uowmail.edu.au
RI Bartschi, Jessica/AAD-6829-2020
OI Larkin, Theresa/0000-0001-5916-7276; Elgellaie,
   Asmahan/0000-0002-2223-3396
FU Illawarra Health and Medical Research Institute; Australian Government
   Research Training Program Scholarship
FX Illawarra Health and Medical Research Institute; Australian Government
   Research Training Program Scholarship
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NR 78
TC 26
Z9 28
U1 1
U2 13
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0953-816X
EI 1460-9568
J9 EUR J NEUROSCI
JI Eur. J. Neurosci.
PD JUN
PY 2023
VL 57
IS 11
BP 1913
EP 1928
DI 10.1111/ejn.15992
EA APR 2023
PG 16
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA H9HD2
UT WOS:000976817000001
PM 37070163
OA Green Submitted, hybrid
DA 2025-06-11
ER

PT J
AU Lemche, AV
   Chaban, OS
   Lemche, E
AF Lemche, Alexandra V.
   Chaban, Oleg S.
   Lemche, Erwin
TI Trait anxiety but not state anxiety level associates with biomarkers for
   hypertension in the metabolic syndrome
SO PSYCHOPHYSIOLOGY
LA English
DT Article
DE Metabolic syndrome; Pulse pressure; Spielberger State-Trait Anxiety
   Inventory; Structural equation modeling; Cross-sectional design; Cohort
   studies; National sample
ID CARDIOVASCULAR RISK; INSULIN-RESISTANCE; SYMPTOMS; PRESSURE; STRESS;
   MIDDLE; BRAIN
AB Various studies link hypertension with anxiety; however, it remains unclarified if such relations are present in the metabolic syndrome (MetS). We studied cross-sectionally the interrelations of self-reported anxiety (Spielberger STAI), and MetS components in MetS patients. We investigated a nationally sampled treatment cohort for MetS with familial Type 2 diabetes risk. N=101 patients fulfilling International Diabetes Federation criteria for MetS participated. Both laboratory and nonlaboratory measures were included. Structural equation models (SEM) were adjusted. The final SEM had an R-2 = .998 with the obesity component linking to waist, BMI, and degree of adiposity, and the hypertension component linking to systolic blood pressure, pulse pressure, total cholesterol, and trait anxiety. For state anxiety, no significant regressive causal path could be estimated. SEM supports the assumption of an interaction of pulse pressure, systolic blood pressure, cholesterol metabolism, and high trait anxiety in the pathophysiology of hypertension in MetS.
C1 [Lemche, Alexandra V.] Charite, Dept Psychosomat Med, D-13353 Berlin, Germany.
   [Chaban, Oleg S.] Bogomolets Natl Med Univ, Sect Neuroses & Somatoform Disorders, Kiev, Ukraine.
   [Lemche, Erwin] Kings Coll London, Inst Psychiat, Sect Cognit Neuropsychiat, Box PO69,De Crespigny Pk, London SE5 8AF, England.
C3 Berlin Institute of Health; Free University of Berlin; Humboldt
   University of Berlin; Charite Universitatsmedizin Berlin; Bogomolets
   National Medical University; University of London; King's College London
RP Lemche, E (corresponding author), Kings Coll London, Inst Psychiat, Sect Cognit Neuropsychiat, Box PO69,De Crespigny Pk, London SE5 8AF, England.
EM erwin.lemche@kcl.ac.uk
RI Chaban, Oleg/ABA-8319-2020
OI Chaban, Oleg/0000-0001-9702-7629
FU National Medical University of the Ukraine, Kiev; center grant on
   "Quality of Life in Diabetes" of the Ministry of Public Health of the
   Ukraine
FX AVL acknowledges intramural funding from the National Medical University
   of the Ukraine, Kiev. OSC was supported by a center grant on "Quality of
   Life in Diabetes" of the Ministry of Public Health of the Ukraine. The
   funders had no role whatsoever in design, analyses, or manuscript
   preparation.
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NR 38
TC 9
Z9 11
U1 0
U2 13
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0048-5772
EI 1469-8986
J9 PSYCHOPHYSIOLOGY
JI Psychophysiology
PD JUN
PY 2016
VL 53
IS 6
BP 914
EP 920
DI 10.1111/psyp.12623
PG 7
WC Psychology, Biological; Neurosciences; Physiology; Psychology;
   Psychology, Experimental
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Neurosciences & Neurology; Physiology
GA DQ1CW
UT WOS:000378939700014
PM 26841205
DA 2025-06-11
ER

PT J
AU Scavello, I
   Maseroli, E
   Cipriani, S
   Di Stasi, V
   Verde, N
   Menafra, D
   Scannerini, S
   Marchiani, S
   Rastrelli, G
   Ricca, V
   Sorbi, F
   Fambrini, M
   Petraglia, F
   Maggi, M
   Vignozzi, L
AF Scavello, I
   Maseroli, E.
   Cipriani, S.
   Di Stasi, V
   Verde, N.
   Menafra, D.
   Scannerini, S.
   Marchiani, S.
   Rastrelli, G.
   Ricca, V
   Sorbi, F.
   Fambrini, M.
   Petraglia, F.
   Maggi, M.
   Vignozzi, Linda
TI Cardiometabolic risk is unraveled by color Doppler ultrasound of the
   clitoral and uterine arteries in women consulting for sexual symptoms
SO SCIENTIFIC REPORTS
LA English
DT Article
ID ARTERIOGENIC ERECTILE DYSFUNCTION; METABOLIC SYNDROME; CARDIOVASCULAR
   RISK; VASCULAR MODIFICATIONS; BLOOD-FLOW; INDEX FSFI; DESIRE; SCALE;
   YOUNG
AB Female sexual dysfunction (FSD) may be a mirror of a poor cardiometabolic state. In a small pilot study enrolling 71 women with FSD, we previously demonstrated that clitoral Pulsatility Index (PI) evaluated by using color Doppler ultrasound (CDU), reflecting vascular resistance, was associated with cardiometabolic risk factors. Data on uterine CDU in this context are lacking. First, to confirm previously reported data on the direct association between clitoral PI and cardiometabolic risk factors on a larger study population of women consulting for sexual symptoms; second, to investigate eventual similar correlations between cardiometabolic risk factors and CDU parameters of the uterine artery. We also ascertained whether uterine artery PI, similarly to what had previously been observed for clitoral artery PI, was directly related to body image uneasiness and psychopathological symptoms, assessed by validated questionnaires. N = 230 women consulting our clinic for sexual symptoms were examined with clitoral CDU and blood sampling and were asked to fill out the Female Sexual Function Index, the Middlesex Hospital Questionnaire (MHQ) and the Body Uneasiness Test (BUT). In a subgroup of women (n = 164), we also performed transvaginal CDU with measurement of uterine artery parameters. At multivariate analysis, we found a direct association between clitoral PI and body mass index (BMI) (p = 0.004), waist circumference (WC) (p = 0.004), triglycerides (p = 0.006), insulin (p = 0.029) and HOMA-IR (p = 0.009). Furthermore, a correlation between obesity and Metabolic Syndrome (MetS) and a higher clitoral PI was observed (p = 0.003 and p = 0.012, respectively). Clitoral PI was also correlated with MHQ-S (p = 0.010), a scale exploring somatized anxiety symptoms, and BUT-B Positive Symptom Distress Index (p = 0.010), a measure of body image concerns. Similarly, when investigating the uterine artery, we were able to demonstrate an association between its PI and BMI (p < 0.0001), WC (p = 0.001), insulin (p = 0.006), glycated haemoglobin (p = < 0.0001), and HOMA-IR (p = 0.009). Women diagnosed with obesity and MetS showed significantly higher uterine PI values vs. those without obesity or MetS (p = 0.001 and p = 0.004, respectively). Finally, uterine PI was associated with BUT-A Global Severity Index (p < 0.0001) and with several other BUT-A subdomains. Vascular resistance of clitoral and uterine arteries is associated with cardiometabolic risk factors and body image concerns in women consulting for sexual symptoms. If further confirmed in different populations, our data could suggest CDU, a common examination method, as a useful tool for an identification-and possible correction-of cardiometabolic risk factors.
C1 [Scavello, I; Cipriani, S.; Di Stasi, V; Rastrelli, G.; Vignozzi, Linda] Univ Florence, Dept Expt Clin & Biomed Sci Mario Serio, Viale Pieraccini 6, I-50134 Florence, Italy.
   [Maseroli, E.; Rastrelli, G.; Vignozzi, Linda] Azienda Osped Univ Careggi, Androl Womens Endocrinol & Gender Incongruence Un, Florence, Italy.
   [Verde, N.; Menafra, D.] Federico II Univ Naples, Clin Med & Surg Dept, Sect Endocrinol, Unit Androl Reprod Med & Male & Female Sexual FER, Naples, Italy.
   [Scannerini, S.; Ricca, V] Univ Florence, Psychiat Unit, Dept Neurosci Psychol Drug Res & Child Hlth, Florence, Italy.
   [Marchiani, S.] Univ Florence, Dept Expt & Clin Med, Florence, Italy.
   [Sorbi, F.; Fambrini, M.; Petraglia, F.] Univ Florence, Dept Biomed Expt & Clin Sci Mario Serio, Gynecol Unit, Florence, Italy.
   [Maggi, M.] Univ Florence, Dept Expt Clin & Biomed Sci Mario Serio, Endocrinol Unit, Florence, Italy.
C3 University of Florence; University of Florence; Azienda Ospedaliero
   Universitaria Careggi; University of Naples Federico II; University of
   Florence; University of Florence; University of Florence; University of
   Florence
RP Vignozzi, L (corresponding author), Univ Florence, Dept Expt Clin & Biomed Sci Mario Serio, Viale Pieraccini 6, I-50134 Florence, Italy.; Vignozzi, L (corresponding author), Azienda Osped Univ Careggi, Androl Womens Endocrinol & Gender Incongruence Un, Florence, Italy.
EM linda.vignozzi@unifi.it
RI ricca, valdo/K-8382-2012; Menafra, Davide/AIE-4129-2022; Marchiani,
   Sara/H-9002-2018; Cipriani, Sarah/ITV-7039-2023; PETRAGLIA,
   Felice/D-4373-2019; Maggi, Mario/AAB-8284-2019; Fambrini,
   Massimiliano/K-5835-2016
OI MAGGI, Mario/0000-0003-3267-4221; Menafra, Davide/0000-0002-4403-6801;
   Fambrini, Massimiliano/0000-0003-0461-6390
FU PRIN ("Progetti di Rilevante Interesse Nazionale") [2017S9KTNE]
FX This research was supported by a PRIN ("Progetti di Rilevante Interesse
   Nazionale": 2017S9KTNE).
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NR 59
TC 10
Z9 10
U1 0
U2 0
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD SEP 22
PY 2021
VL 11
IS 1
AR 18899
DI 10.1038/s41598-021-98336-7
PG 12
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Science & Technology - Other Topics
GA UW6XJ
UT WOS:000700297100027
PM 34552164
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Kunin-Batson, AS
   Crain, AL
   Sherwood, NE
   Kelly, AS
   Kharbanda, EO
   Gunnar, MR
   Haapala, J
   Seburg, EM
   French, SA
AF Kunin-Batson, Alicia S.
   Crain, A. Lauren
   Sherwood, Nancy E.
   Kelly, Aaron S.
   Kharbanda, Elyse O.
   Gunnar, Megan R.
   Haapala, Jacob
   Seburg, Elisabeth M.
   French, Simone A.
TI Do Children's Health Behaviors Buffer the Impact of Cumulative
   Environmental Stress on Emerging Cardiometabolic Risk?
SO JOURNAL OF THE AMERICAN HEART ASSOCIATION
LA English
DT Article
DE childhood; health behaviors; obesity; stress
ID VIGOROUS PHYSICAL-ACTIVITY; C-REACTIVE PROTEIN; LONGITUDINAL
   ASSOCIATIONS; OBESITY; NEIGHBORHOOD; OPPORTUNITY; INTERVENTION;
   FAMILIES; RATIO
AB Background: Previous studies have found that exposure to childhood environmental stress is associated with cardiometabolic risk. However, it is not known whether individual health behaviors disrupt this relationship. This study prospectively evaluated the relationship between cumulative environmental stress in a low-income sample and cardiometabolic risk in middle childhood and examined whether child health behaviors attenuated this relationship. Methods and Results: In a cohort of children (n=338; 57% Hispanic children; 25% Black children), environmental stressors (family and neighborhood factors representing disadvantage/deprivation) and child health behaviors (accelerometry measured physical activity; parent-reported screen time and diet recalls) were measured over 5 time points beginning when children were aged 2 to 4 years and ending when they were aged 7 to 11 years. Children's cardiometabolic risk factors (body mass index, blood pressure, triglyceride/high-density lipoprotein ratio, glucose, hemoglobin A(1c), C-reactive protein) were measured at 7 to 11 years. Emerging cardiometabolic risk was defined as having >= 1 elevations that exceeded clinical thresholds. In adjusted path analyses, greater cumulative environmental stress was associated with higher likelihood of emerging cardiometabolic risk in middle childhood (P<0.001). Higher levels of moderate to vigorous physical activity and fewer sedentary minutes attenuated the positive relationship between stress and cardiometabolic risk (P<0.05). Children with >2 hours of average daily screen time had a higher likelihood of elevated cardiometabolic risk (P<0.01), but screen time did not moderate the stress-cardiometabolic risk relationship. Dietary intake was not related to cardiometabolic risk. Conclusions: Interventions that promote moderate to vigorous physical activity and limit sedentary behavior may have particular importance for the cardiometabolic health of children exposed to high levels of cumulative environmental stress.
C1 [Kunin-Batson, Alicia S.; Kelly, Aaron S.] Univ Minnesota, Med Sch, Dept Pediat, 717 Delaware St SE, Minneapolis, MN 55414 USA.
   [Kunin-Batson, Alicia S.; Kelly, Aaron S.] Univ Minnesota, Ctr Pediat Obes Med, Med Sch, 717 Delaware St SE, Minneapolis, MN 55414 USA.
   [Crain, A. Lauren; Kharbanda, Elyse O.; Haapala, Jacob; Seburg, Elisabeth M.] HealthPartners Inst, Bloomington, MN USA.
   [Sherwood, Nancy E.; French, Simone A.] Univ Minnesota, Sch Publ Hlth, Div Epidemiol & Community Hlth, Minneapolis, MN 55414 USA.
   [Gunnar, Megan R.] Univ Minnesota, Inst Child Dev, Minneapolis, MN 55436 USA.
C3 University of Minnesota System; University of Minnesota Twin Cities;
   University of Minnesota System; University of Minnesota Twin Cities;
   HealthPartners Institute for Education & Research; University of
   Minnesota System; University of Minnesota Twin Cities; University of
   Minnesota System; University of Minnesota Twin Cities
RP Kunin-Batson, AS (corresponding author), Univ Minnesota, Med Sch, Dept Pediat, 717 Delaware St SE, Minneapolis, MN 55414 USA.; Kunin-Batson, AS (corresponding author), Univ Minnesota, Ctr Pediat Obes Med, Med Sch, 717 Delaware St SE, Minneapolis, MN 55414 USA.
EM kunin003@umn.edu
RI Kunin-Batson, Alicia/GQY-8621-2022
OI French, Simone/0000-0003-3413-5985; Sherwood, Nancy/0000-0002-3365-9018;
   Kharbanda, Elyse/0000-0003-1806-6502; Crain, A
   Lauren/0000-0002-5050-945X; Kunin-Batson, Alicia/0000-0002-7607-5602
FU Eunice Kennedy Shriver National Institute of Child Health and Human
   Development of the National Institutes of Health [R01HD090059,
   U01HD068990]; Center for Neurobehavioral Development, University of
   Minnesota
FX This work was supported by the Eunice Kennedy Shriver National Institute
   of Child Health and Human Development of the National Institutes of
   Health under award numbers R01HD090059 and U01HD068990, and in part by
   the Center for Neurobehavioral Development, University of Minnesota.
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NR 60
TC 0
Z9 0
U1 1
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
EI 2047-9980
J9 J AM HEART ASSOC
JI J. Am. Heart Assoc.
PD SEP 17
PY 2024
VL 13
IS 18
AR e032492
DI 10.1161/JAHA.123.032492
PG 12
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA G1Y7Z
UT WOS:001314672800009
PM 39248253
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Mücke, M
   Ludyga, S
   Colledge, F
   Gerber, M
AF Mucke, Manuel
   Ludyga, Sebastian
   Colledge, Flora
   Gerber, Markus
TI Influence of Regular Physical Activity and Fitness on Stress Reactivity
   as Measured with the Trier Social Stress Test Protocol: A Systematic
   Review
SO SPORTS MEDICINE
LA English
DT Review
ID PSYCHOSOCIAL STRESS; CARDIOVASCULAR REACTIVITY; PSYCHOLOGICAL STRESS;
   PHYSIOLOGICAL-RESPONSE; CORTISOL RESPONSES; METABOLIC SYNDROME;
   LABORATORY STRESS; EXERCISE; HEALTH; RECOVERY
AB Background Psychosocial stress is associated with multiple health complaints. Research to date suggests that regular physical activity (PA) and higher cardiorespiratory fitness may reduce stress reactivity and therefore contribute to a reduction of stress-related risk factors. While previous reviews have not differentiated between stressors, we focus on psychosocial stress elicited with the Trier Social Stress Test (TSST).
   Objective Our objective was to examine the effect of regular PA and cardiorespiratory fitness on stress reactivity, with a particular focus on the TSST. The TSST is the laboratory task most widely used to induce socio-evaluative stress and elicits stronger stress reactions than most other cognitive stressor tasks.
   Methods A systematic search within various databases was performed in January 2018. The following outcomes were considered: cortisol, heart rate, psychological stress reactivity, and potential moderators (age, sex, exercise intensity, assessment mode, and psychological constructs).
   Results In total, 14 eligible studies were identified. Cortisol and heart rate reactivity were attenuated by higher PA or better fitness in seven of twelve studies and four of nine studies, respectively. Two of four studies reported smaller increases in anxiety and smaller decreases in calmness in physically active/fitter participants. Three of four studies found that higher PA/fitness was associated with more favorable mood in response to the TSST.
   Conclusion About half of the studies suggested that higher PA/fitness levels were associated with an attenuated response to psychosocial stress. Currently, most evidence is based on cross-sectional analyses. Therefore, a great need for further studies with longitudinal or experimental designs exists.
C1 [Mucke, Manuel; Gerber, Markus] Univ Basel, Div Sport & Psychosocial Hlth, Dept Sport Exercise & Hlth, Birsstr 320 B, CH-4052 Basel, Switzerland.
   [Ludyga, Sebastian; Colledge, Flora] Univ Basel, Div Sport & Hlth Pedag, Dept Sport Exercise & Hlth, Birsstr 320 B, CH-4052 Basel, Switzerland.
C3 Swiss School of Public Health (SSPH+); University of Basel; Swiss School
   of Public Health (SSPH+); University of Basel
RP Mücke, M (corresponding author), Univ Basel, Div Sport & Psychosocial Hlth, Dept Sport Exercise & Hlth, Birsstr 320 B, CH-4052 Basel, Switzerland.
EM manuel.muecke@unibas.ch
RI Gerber, Markus/H-8654-2014; Hanke, Manuel/AFZ-0876-2022; Ludyga,
   Sebastian/H-9316-2019
OI Ludyga, Sebastian/0000-0002-3905-7894; Gerber,
   Markus/0000-0001-6140-8948
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NR 86
TC 121
Z9 126
U1 1
U2 48
PU ADIS INT LTD
PI NORTHCOTE
PA 5 THE WAREHOUSE WAY, NORTHCOTE 0627, AUCKLAND, NEW ZEALAND
SN 0112-1642
EI 1179-2035
J9 SPORTS MED
JI Sports Med.
PD NOV
PY 2018
VL 48
IS 11
BP 2607
EP 2622
DI 10.1007/s40279-018-0979-0
PG 16
WC Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Sport Sciences
GA GW9AW
UT WOS:000447274700009
PM 30159718
DA 2025-06-11
ER

PT J
AU Funakubo, N
   Eguchi, E
   Hayashi, R
   Hirosaki, M
   Shirai, K
   Okazaki, K
   Nakano, H
   Hayashi, F
   Omata, J
   Imano, H
   Iso, H
   Ohira, T
AF Funakubo, Narumi
   Eguchi, Eri
   Hayashi, Rie
   Hirosaki, Mayumi
   Shirai, Kokoro
   Okazaki, Kanako
   Nakano, Hironori
   Hayashi, Fumikazu
   Omata, Junichi
   Imano, Hironori
   Iso, Hiroyasu
   Ohira, Tetsuya
TI Effects of a laughter program on body weight and mental health among
   Japanese people with metabolic syndrome risk factors: a randomized
   controlled trial
SO BMC GERIATRICS
LA English
DT Article
DE Body mass index; Happiness; Health-related quality of life; Laughter
   yoga; Revised life orientation test; Stress
ID QUALITY-OF-LIFE; CARDIOVASCULAR-DISEASE; EXERCISE PROGRAM; STRESS;
   NEUROENDOCRINE; OPTIMISM; VERSION; IMPACT; YOGA
AB Background: While there have been several intervention studies on the psychological effects of laughter, few have examined both the psychological and physical effects. This study investigates the effects of a laughter program on body weight, body mass index (BMI), subjective stress, depression, and health-related quality of life (HRQOL) among Japanese community-dwelling individuals using a randomized controlled trial with a waitlist.
   Methods: Overall, 235 participants (37 men and 198 women) aged 43-79 years (mean 66.9, median 67.0) were randomized into laughter intervention and control groups (n = 117 and n = 118, respectively) to participate in a 12-week laughter program. Body weight, subjective stress, subjective well-being, and HRQOL were measured at the baseline, with a 12-week follow-up. The laughter program intervention's effects on these factors were analyzed using an analysis of covariance adjusted by age, sex, risk factors, medication, and area. Furthermore, Pearson's correlation and a general linear model analyzed the relationship between participants' BMI and psychological index changes.
   Results: The comprehensive laughter program significantly improved the mean body weight (p = 0.008), BMI (p= 0.006), subjective stress (p= 0.004), subjective well-being (p = 0.002), optimism (p = 0.03), and physical component summary (PCS) scores of HRQOL (p= 0.04). A similar tendency occurred for the mean changes in BMI and subjective stress score by area, sex, and age. Moreover, there was a significant and negative correlation between the change in BMI and PCS change (p = 0.04).
   Conclusion: The comprehensive 12-week laughter intervention program, mainly comprising laughter yoga, significantly improved physical and psychological functions such as body weight, BMI, subjective stress, subjective well-being, and HRQOL among predominantly elderly Japanese community-dwelling individuals with metabolic syndrome risk factors. Moreover, PCS improved among participants who reduced BMI after the intervention. These results suggest that the laughter program may help reduce body weight in participants with metabolic syndrome risk factors by reducing stress and improving HRQOL and mental health factors, such as subjective well-being and optimism.
C1 [Funakubo, Narumi; Eguchi, Eri; Hirosaki, Mayumi; Okazaki, Kanako; Nakano, Hironori; Hayashi, Fumikazu; Ohira, Tetsuya] Fukushima Med Univ, Dept Epidemiol, Sch Med, 1 Hikarigaoka, Fukushima 9601295, Japan.
   [Hayashi, Rie; Shirai, Kokoro; Imano, Hironori; Iso, Hiroyasu] Osaka Univ, Dept Social Med, Grad Sch Med, Publ Hlth, Osaka, Japan.
   [Hirosaki, Mayumi] Kyoto Univ, Ctr Southeast Asian Studies, Kyoto, Japan.
   [Okazaki, Kanako; Omata, Junichi] Fukushima Med Univ, Dept Phys Therapy, Sch Hlth Sci, Fukushima, Japan.
   [Okazaki, Kanako; Nakano, Hironori; Hayashi, Fumikazu; Ohira, Tetsuya] Fukushima Med Univ, Radiat Med Sci Ctr Fukushima Hlth Management Surv, Fukushima, Japan.
   [Omata, Junichi] Fukushima Med Univ, Dept Anat, Sch Med, Fukushima, Japan.
   [Imano, Hironori] Kindai Univ, Dept Publ Hlth, Fac Med, Osaka, Japan.
C3 Fukushima Medical University; The University of Osaka; Kyoto University;
   Fukushima Medical University; Fukushima Medical University; Fukushima
   Medical University; Kindai University (Kinki University)
RP Ohira, T (corresponding author), Fukushima Med Univ, Dept Epidemiol, Sch Med, 1 Hikarigaoka, Fukushima 9601295, Japan.; Ohira, T (corresponding author), Fukushima Med Univ, Radiat Med Sci Ctr Fukushima Hlth Management Surv, Fukushima, Japan.
EM teoohira@fmu.ac.jp
RI OMATA, JUNICHI/JZF-9999-2024; HIROSAKI, Mayumi/HCH-1388-2022
OI hayashi, fumikazu/0000-0002-6888-6640; Eguchi, Eri/0000-0002-1598-1847
FU Japan Agency for Medical Research and Development [JP16lk0310019h0001,
   JP17lk0310035h0001]; Foundation for Total Health Promotion [408]; Japan
   Society for the Promotion of Science (JSPS) KAKENHI [18 K19688,
   19H03901, 20 K21719]
FX This research was supported by the Japan Agency for Medical Research and
   Development under Grant Agreement Nos [JP16lk0310019h0001 and
   JP17lk0310035h0001] and Foundation for Total Health Promotion (408) and
   Japan Society for the Promotion of Science (JSPS) KAKENHI under Grant
   Agreement Nos [18 K19688, 19H03901, and 20 K21719].
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NR 42
TC 5
Z9 5
U1 0
U2 13
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2318
J9 BMC GERIATR
JI BMC Geriatr.
PD APR 23
PY 2022
VL 22
IS 1
AR 361
DI 10.1186/s12877-022-03038-y
PG 12
WC Geriatrics & Gerontology; Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA 0S0IX
UT WOS:000785967600004
PM 35461239
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Doom, JR
   Reid, BM
   Blanco, E
   Burrows, R
   Lozoff, B
   Gahagan, S
AF Doom, Jenalee R.
   Reid, Brie M.
   Blanco, Estela
   Burrows, Raquel
   Lozoff, Betsy
   Gahagan, Sheila
TI Infant Psychosocial Environment Predicts Adolescent Cardiometabolic
   Risk: A Prospective Study
SO JOURNAL OF PEDIATRICS
LA English
DT Article
ID ADVERSE CHILDHOOD EXPERIENCES; BODY-MASS INDEX; CARDIOVASCULAR RISK;
   METABOLIC SYNDROME; HEALTH; DISEASE; OBESITY; STRESS; LIFE; PREVALENCE
AB Objective To prospectively assess whether the infant psychosocial environment was associated with cardiometabolic risk as early as adolescence.
   Study design Participants were recruited in Santiago, Chile, and have been followed from infancy. Inclusion criteria included healthy infants with birth weight >= 3 kg and a stable caregiver. The psychosocial environment, including depressive symptoms, stressful life events, poor support for child development, father absence, and socioeconomic status, was reported by mothers at 6-12 months. Body mass index (BMI) z score was assessed at 5 and 10 years. BMI z score, waist-to-hip ratio, systolic and diastolic blood pressure, fat mass and body fat percentage, fasting glucose, total and high-density lipoprotein cholesterol, and homeostatic model of insulin resistance were tested in adolescence.
   Results Adolescents ranged from 16 to 18 years of age (n = 588; 48.1 % female). A poorer infant psychosocial environment was associated with BMI z score at 10 years (beta = 0.10, 95% CI = 0.00-0.19) and in adolescence (beta = 0.15, 95% CI = 0.06-0.24) but not at 5 years. A poorer infant psychosocial environment was associated with higher blood pressure (beta = 0.15, 95% CI = 0.05-0.24), greater anthropometric risk (beta = 0.13, 95% CI = 0.03-0.22), greater biomarker (triglycerides, homeostatic model assessment of insulin resistance, total cholesterol) risk (beta = 0.12, 95% CI = 0.02-0.22), and a higher likelihood of metabolic syndrome in adolescence (aOR = 1.50; 95% CI = 1.062.12).
   Conclusions These findings demonstrate that a poorer infant psychosocial environment was associated with greater adolescent cardiometabolic risk. The results support screening for infants' psychosocial environments and further research into causality, mechanisms, prevention, and intervention.
C1 [Doom, Jenalee R.; Lozoff, Betsy; Gahagan, Sheila] Univ Michigan, Ctr Human Growth & Dev, 300 N Ingalls St,10th Floor, Ann Arbor, MI 48109 USA.
   [Doom, Jenalee R.; Lozoff, Betsy] Univ Michigan, Dept Pediat, Ann Arbor, MI 48109 USA.
   [Reid, Brie M.] Univ Minnesota, Inst Child Dev, 51 E River Rd, Minneapolis, MN 55455 USA.
   [Blanco, Estela; Gahagan, Sheila] Univ Calif San Diego, Dept Pediat, San Diego, CA 92103 USA.
   [Blanco, Estela] Univ Chile, Sch Publ Hlth, Doctoral Program Publ Hlth, Santiago, Chile.
   [Burrows, Raquel] Univ Chile, Inst Nutr & Tecnol Alimentos, Santiago, Chile.
C3 University of Michigan System; University of Michigan; University of
   Michigan System; University of Michigan; University of Minnesota System;
   University of Minnesota Twin Cities; University of California System;
   University of California San Diego; Universidad de Chile; Universidad de
   Chile
RP Doom, JR (corresponding author), Univ Michigan, Ctr Human Growth & Dev, 300 N Ingalls St,10th Floor, Ann Arbor, MI 48109 USA.
EM jrdoom@umich.edu
RI Burrows, Raquel/A-8489-2015; Blanco, Estela/AAI-9276-2021; Reid,
   Brie/ABC-9782-2020; Blanco, Estela/A-2541-2014
OI Doom, Jenalee/0000-0003-2857-0817; Blanco, Estela/0000-0002-6232-9210;
   Burrows, Raquel/0000-0001-9155-0689
FU National Institutes of Health [F32HD088029, R01HD14122, R01HD33487,
   R01HL088530]
FX Funded by the National Institutes of Health (F32HD088029 [to J.D.],
   R01HD14122 [to B.L.], R01HD33487 [to B.L. and S.G.], and R01HL088530 [to
   S.G.]). The funder had no role in the study design; the collection,
   analysis, and interpretation of data; the writing of the report; or the
   decision to submit the manuscript for publication. The authors declare
   no conflicts of interest.
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NR 37
TC 12
Z9 12
U1 1
U2 7
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0022-3476
EI 1097-6833
J9 J PEDIATR-US
JI J. Pediatr.
PD JUN
PY 2019
VL 209
BP 85
EP +
DI 10.1016/j.jpeds.2019.01.058
PG 8
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Pediatrics
GA HZ1OA
UT WOS:000468615300017
PM 30876752
OA Bronze, Green Accepted
DA 2025-06-11
ER

PT J
AU Albaladejo-Blázquez, N
   Ferrer-Cascales, R
   Ruiz-Robledillo, N
   Sánchez-Sansegundo, M
   Clement-Carbonell, V
   Zaragoza-Martí, A
AF Albaladejo-Blazquez, Natalia
   Ferrer-Cascales, Rosario
   Ruiz-Robledillo, Nicolas
   Sanchez-Sansegundo, Miriam
   Clement-Carbonell, Violeta
   Zaragoza-Marti, Ana
TI Poor Dietary Habits in Bullied Adolescents: The Moderating Effects of
   Diet on Depression
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Article
DE bullying; diet; depression; adolescents
ID MEDITERRANEAN DIET; BULLYING VICTIMIZATION; METABOLIC SYNDROME;
   PERCEIVED STRESS; ALLOSTATIC LOAD; MENTAL-HEALTH; ASSOCIATION; QUALITY;
   CHILDREN; LIFE
AB The prevalence of bullying has increased dramatically during recent years, with numerous negative consequences for the health and quality of life of bullied adolescents. Although negative psychological consequences of this type of situation have been widely investigated, no previous research has evaluated the effects of bullying victimization on dietary habits, and its relationship with psychological outcomes, such as depression. For this reason, the main aim of the present study was to evaluate the association between bullying, dietary habits, and depression in a sample of 527 Spanish adolescents. The results obtained showed that being bullied was correlated negatively with healthy dietary habits and positively with depression. Moderation analysis revealed dietary habits as moderator of the association between bullying and depression. These results underline the relevance of diet in the phenomenon of bullying, especially in victims, as could be related to the high levels of depression characteristic of this population. The inclusion of nutritional education in intervention programs oriented to victims of bullying might significantly improve their efficacy, reducing depression levels.
C1 [Albaladejo-Blazquez, Natalia; Ferrer-Cascales, Rosario; Ruiz-Robledillo, Nicolas; Sanchez-Sansegundo, Miriam; Clement-Carbonell, Violeta] Univ Alicante, Fac Hlth Sci, Dept Hlth Psychol, Alicante 03690, Spain.
   [Zaragoza-Marti, Ana] Univ Alicante, Fac Hlth Sci, Dept Nursing, Alicante 03690, Spain.
C3 Universitat d'Alacant; Universitat d'Alacant
RP Ferrer-Cascales, R (corresponding author), Univ Alicante, Fac Hlth Sci, Dept Hlth Psychol, Alicante 03690, Spain.
EM natalia.albaladejo@ua.es; rosario.ferrer@ua.es; nicolas.ruiz@ua.es;
   miriam.sanchez@ua.es; violeta.clement@ua.es; ana.zaragoza@ua.es
RI Clement, Violeta/U-3474-2017; Sanchez-SanSegundo, Miriam/U-3451-2017;
   Marí, Ana/U-3449-2017; Ferrer-Cascales, R./U-3448-2017; Ruiz-Robledillo,
   Nicolas/U-3452-2017; Albaladejo-Blazquez, Natalia/U-3453-2017
OI Ferrer-Cascales, R./0000-0001-6015-7454; Ruiz-Robledillo,
   Nicolas/0000-0002-7522-5162; Sanchez-SanSegundo,
   Miriam/0000-0003-2114-6503; Albaladejo-Blazquez,
   Natalia/0000-0002-9116-9092
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NR 42
TC 11
Z9 11
U1 2
U2 18
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD AUG
PY 2018
VL 15
IS 8
AR 1569
DI 10.3390/ijerph15081569
PG 10
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA GS0GQ
UT WOS:000443168200009
PM 30042364
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Reynolds, MA
AF Reynolds, Mark A.
TI Modifiable risk factors in periodontitis: at the intersection of aging
   and disease
SO PERIODONTOLOGY 2000
LA English
DT Review
ID BODY-MASS INDEX; POLYUNSATURATED FATTY-ACIDS; ALCOHOL-CONSUMPTION;
   METABOLIC SYNDROME; CARDIOVASCULAR-DISEASE; COMORBIDITY MEASURES;
   INSULIN-RESISTANCE; SEXUAL-DIMORPHISM; HEART-DISEASE;
   PORPHYROMONAS-GINGIVALIS
AB Chronic inflammation is a prominent feature of aging and of common age-related diseases, including atherosclerosis, cancer and periodontitis. This volume examines modifiable risk factors for periodontitis and other chronic inflammatory diseases. Oral bacterial communities and viral infections, particularly with cytomegalovirus and other herpesviruses, elicit distinct immune responses and are central in the initiation of periodontal diseases. Risk of disease is dynamic and changes in response to complex interactions of genetic, environmental and stochastic factors over the lifespan. Many modifiable risk factors, such as smoking and excess caloric intake, contribute to increases in systemic markers of inflammation and can modify gene regulation through a variety of biologic mechanisms (e.g. epigenetic modifications). Periodontitis and other common chronic inflammatory diseases share multiple modifiable risk factors, such as tobacco smoking, psychological stress and depression, alcohol consumption, obesity, diabetes, metabolic syndrome and osteoporosis. Interventions that target modifiable risk factors have the potential to improve risk profiles for periodontitis as well as for other common chronic diseases.
RI Reynolds, Mark/AAO-9707-2021
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NR 174
TC 138
Z9 156
U1 0
U2 73
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0906-6713
EI 1600-0757
J9 PERIODONTOL 2000
JI Periodontol. 2000
PD FEB
PY 2014
VL 64
IS 1
BP 7
EP 19
DI 10.1111/prd.12047
PG 13
WC Dentistry, Oral Surgery & Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dentistry, Oral Surgery & Medicine
GA 268FX
UT WOS:000328156500001
PM 24320953
DA 2025-06-11
ER

PT J
AU Conti, C
   Di Francesco, G
   Severo, M
   Lanzara, R
   Richards, K
   Guagnano, MT
   Porcelli, P
AF Conti, Chiara
   Di Francesco, Giulia
   Severo, Melania
   Lanzara, Roberta
   Richards, Katie
   Guagnano, Maria Teresa
   Porcelli, Piero
TI Alexithymia and metabolic syndrome: the mediating role of binge eating
SO EATING AND WEIGHT DISORDERS-STUDIES ON ANOREXIA BULIMIA AND OBESITY
LA English
DT Article
DE Alexithymia; Binge eating; Distress; Metabolic syndrome; Obesity;
   Structural equation modeling
ID 3RD NATIONAL-HEALTH; HOSPITAL ANXIETY; OBESE-PATIENTS; PREVALENCE;
   DEPRESSION; DISORDERS; SCALE; COMORBIDITY; PERSONALITY; POPULATION
AB Purpose Alexithymia, a personality trait characterized by difficulties in emotional processing, has been associated with unhealthy behaviors and chronic medical conditions. This study aimed to further develop our understanding of this complex relationship by investigating whether alexithymia increases the risk of metabolic syndrome (MetS) in participants with obesity or overweight through the mediating role of binge eating (BE). Methods A consecutive sample of 238 treatment-seeking patients with obesity or overweight were recruited. Alexithymia (TAS-20), binge eating symptoms (BES), body mass index (BMI), and depression and anxiety symptoms (HADS) were concurrently assessed. Results Almost half of the participants met the criteria for MetS (44.12%). Compared to patients without MetS, those with MetS were older, had a longer duration of overweight, and had a higher BMI (p < 0.01). Individual with MetS also had higher HADS, BES, and TAS-20 scores, particularly difficulty identifying and describing feelings. The structural equation modeling (SEM) analysis revealed that BES levels exerted a significant direct effect on MetS (p < 0.01), and that TAS-20 levels exerted a significant direct effect on BES (p < 0.01), anxiety (p < 0.001) and depression (p < 0.001). Moreover, psychological distress (anxiety,p = 0.01, and depression,p = .05) indirectly affected MetS through the mediating effect of BES, and TAS-20 (p = 0.01) indirectly affected MetS through the mediating effect of HADS and BES. Finally, age had a significant direct effect on MetS (p < 0.001). Conclusion Our findings indicate that alexithymia is a concurrent causative factor to the development of MetS through the mediating role of BE and psychological distress.
C1 [Conti, Chiara; Di Francesco, Giulia; Severo, Melania; Porcelli, Piero] Univ G dAnnunzio, Dept Psychol Hlth & Territorial Sci, Via Vestini 31, I-66100 Chieti, Italy.
   [Lanzara, Roberta] Sapienza Univ Rome, Dept Dynam & Clin Psychol, Rome, Italy.
   [Richards, Katie] Kings Coll London, Dept Psychol Med, London, England.
   [Guagnano, Maria Teresa] Univ G dAnnunzio, Dept Med & Aging, Chieti, Italy.
C3 G d'Annunzio University of Chieti-Pescara; Sapienza University Rome;
   University of London; King's College London; G d'Annunzio University of
   Chieti-Pescara
RP Conti, C (corresponding author), Univ G dAnnunzio, Dept Psychol Hlth & Territorial Sci, Via Vestini 31, I-66100 Chieti, Italy.
EM cconti@unich.it
RI Porcelli, Piero/AAU-3921-2021; Richards, Katie/GXV-3017-2022; SEVERO,
   Melania/HKE-8612-2023; GUAGNANO, MARIA TERESA/AAT-1701-2021
OI Richards, Katie/0000-0003-3826-6317; Severo, Melania/0000-0003-1929-497X
FU Universita degli Studi G. D'Annunzio Chieti Pescara within the CRUI-CARE
   Agreement; Health Foundation Scaling Up programme
FX Open access funding provided by Universita degli Studi G. D'Annunzio
   Chieti Pescara within the CRUI-CARE Agreement. This research did not
   receive any specific grant from funding agencies in the public,
   commercial, or not-for-profit sectors. KR is supported by the Health
   Foundation Scaling Up programme.
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NR 61
TC 8
Z9 8
U1 1
U2 7
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1124-4909
EI 1590-1262
J9 EAT WEIGHT DISORD-ST
JI Eat. Weight Disord.-Stud. Anorex.
PD AUG
PY 2021
VL 26
IS 6
BP 1813
EP 1823
DI 10.1007/s40519-020-00964-x
EA SEP 2020
PG 11
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychiatry
GA TP6JK
UT WOS:000568984700001
PM 32920774
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Stancliffe, RA
   Thorpe, T
   Zemel, MB
AF Stancliffe, Renee A.
   Thorpe, Teresa
   Zemel, Michael B.
TI Dairy attentuates oxidative and inflammatory stress in metabolic
   syndrome
SO AMERICAN JOURNAL OF CLINICAL NUTRITION
LA English
DT Article
ID INSULIN-RESISTANCE SYNDROME; DIETARY PATTERNS; BLOOD-PRESSURE;
   CARDIOVASCULAR-DISEASE; SYSTEMIC INFLAMMATION; VITAMIN-D; CALCIUM;
   MARKERS; CONSUMPTION; PLASMA
AB Background: Oxidative and inflammatory stress are elevated in obesity and are further augmented in metabolic syndrome. We showed previously that dairy components suppress the adipocyte- and macrophage-mediated generation of reactive oxygen species and inflammatory cytokines and systemic oxidative and inflammatory biomarkers in obesity.
   Objective: The objective of this study was to determine the early (7 d) and sustained (4 and 12 wk) effects of adequate-dairy (AD) compared with low-dairy (LD) diets in subjects with metabolic syndrome.
   Design: Forty overweight and obese adults with metabolic syndrome were randomly assigned to receive AD (3.5 daily servings) or LD (<0.5 daily servings) weight-maintenance diets for 12 wk. Oxidative and inflammatory biomarkers were assessed at 0, 1, 4, and 12 wk as primary outcomes; body weight and composition were measured at 0, 4, and 12 wk as secondary outcomes.
   Results: AD decreased malondialdehyde and oxidized LDL at 7 d (35% and 11%, respectively; P < 0.01), with further decreases by 12 wk. Inflammatory markers were suppressed with intake of AD, with decreases in tumor necrosis factor-alpha at 7 d and further reductions through 12 wk (35%; P < 0.05); decreases in interleukin-6 (21%; P < 0.02) and monocyte chemoattractant protein 1 (14% decrease at 4 wk, 24% decrease at 12 wk; P < 0.05); and a corresponding 55% increase in adiponectin at 12 wk (P < 0.01). LD exerted no effect on oxidative or inflammatory markers. Diet had no effect on body weight; however, AD significantly reduced waist circumference and trunk fat (P < 0.01 for both), and LD exerted no effect.
   Conclusion: An increase in dairy intake attenuates oxidative and inflammatory stress in metabolic syndrome. This trial was registered at clinicaltrials.gov as NCT01266330. Am J Clin Nutr 2011;94:422-30.
C1 [Stancliffe, Renee A.; Thorpe, Teresa; Zemel, Michael B.] Univ Tennessee, Dept Nutr, Knoxville, TN 37996 USA.
C3 University of Tennessee System; University of Tennessee Knoxville
RP Zemel, MB (corresponding author), Univ Tennessee, Dept Nutr, 1215 W Cumberland Ave,Room 229, Knoxville, TN 37996 USA.
EM mzemel@utk.edu
OI Zemel, Michael/0000-0003-4104-5750
FU National Dairy Council
FX Supported by the National Dairy Council and administered by the Dairy
   Research Institute.
CR Choi HK, 2005, ARCH INTERN MED, V165, P997, DOI 10.1001/archinte.165.9.997
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NR 37
TC 137
Z9 155
U1 1
U2 19
PU AMER SOC NUTRITION-ASN
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0002-9165
EI 1938-3207
J9 AM J CLIN NUTR
JI Am. J. Clin. Nutr.
PD AUG
PY 2011
VL 94
IS 2
BP 422
EP 430
DI 10.3945/ajcn.111.013342
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 794TT
UT WOS:000292924900010
PM 21715516
OA Bronze, Green Accepted, Green Published
DA 2025-06-11
ER

PT J
AU Weiss, T
   Skelton, K
   Phifer, J
   Jovanovic, T
   Gillespie, CF
   Smith, A
   Umpierrez, G
   Bradley, B
   Ressler, KJ
AF Weiss, Tamara
   Skelton, Kelly
   Phifer, Justine
   Jovanovic, Tanja
   Gillespie, Charles F.
   Smith, Alicia
   Umpierrez, Guillermo
   Bradley, Bekh
   Ressler, Kerry J.
TI Posttraumatic stress disorder is a risk factor for metabolic syndrome in
   an impoverished urban population
SO GENERAL HOSPITAL PSYCHIATRY
LA English
DT Article
DE Posttraumatic stress disorder; Depression; African American; Minority;
   Trauma; Child abuse; Childhood maltreatment; Psychiatry
ID 3RD NATIONAL-HEALTH; CARDIOVASCULAR-DISEASE; TRAUMA EXPOSURE;
   PRIMARY-CARE; SOCIOECONOMIC-STATUS; ALL-CAUSE; PREVALENCE; MORTALITY;
   VETERANS; PTSD
AB Objective: Metabolic syndrome is associated with elevated risk for cardiovascular disease and diabetes and has increased prevalence in low-income African Americans, which constitutes a significant health disparity. The mechanisms responsible for this disparity remain unclear; the current study investigated the relationship between posttraumatic stress disorder (PTSD) and metabolic syndrome.
   Method: We assessed childhood and adult trauma history, major depressive disorder, PTSD and the components of metabolic syndrome in an urban population. We recruited 245 low-socioeconomic-status, primarily African American subjects from general medical clinics in an inner-city hospital.
   Results: Trauma exposure was extremely prevalent, with 90.6% of subjects reporting at least one significant trauma and 18.8% of subjects meeting criteria for current PTSD. Metabolic syndrome was also prevalent in this population (33.2%), with significantly higher rates among patients with current PTSD (47.8%, P <.05). After controlling for demographics, smoking history, antipsychotic use, depression and exercise, current PTSD remained the only significant predictor of metabolic syndrome (P=.006).
   Conclusions: PTSD is associated with increased rates of metabolic syndrome within a traumatized, impoverished urban population. Further studies should investigate if PTSD treatment may reduce the rates of metabolic syndrome, improve overall health outcomes and decrease health care disparities in minority populations. (C) 2011 Elsevier Inc. All rights reserved.
C1 [Weiss, Tamara; Phifer, Justine; Jovanovic, Tanja; Gillespie, Charles F.; Bradley, Bekh; Ressler, Kerry J.] Emory Univ, Sch Med, Dept Psychiat & Behav Sci, Atlanta, GA 30329 USA.
   [Smith, Alicia] Emory Univ, Sch Med, Dept Human Genet, Atlanta, GA 30329 USA.
   [Umpierrez, Guillermo] Emory Univ, Sch Med, Dept Med, Atlanta, GA 30329 USA.
   [Ressler, Kerry J.] Howard Hughes Med Inst, Chevy Chase, MD 20815 USA.
   [Skelton, Kelly; Bradley, Bekh] Atlanta VA Med Ctr, Decatur, GA 30033 USA.
   [Ressler, Kerry J.] Yerkes Natl Primate Res Ctr, Atlanta, GA 30322 USA.
C3 Emory University; Emory University; Emory University; Howard Hughes
   Medical Institute; US Department of Veterans Affairs; Veterans Health
   Administration (VHA); Atlanta VA Medical Center; Atlanta VA Health Care
   System
RP Ressler, KJ (corresponding author), Emory Univ, Howard Hughes Med Inst, Dept Psychiat & Behav Sci, Yerkes Res Ctr, Atlanta, GA 30329 USA.
EM kressle@emory.edu
RI Smith, Alicia/W-6809-2019; Jovanovic, Tanja/K-4095-2014; Bradley,
   Bekh/H-8399-2012; Gillespie, Charles/G-8481-2012; Ressler,
   Kerry/N-8741-2018
OI Ressler, Kerry/0000-0002-5158-1103; Gillespie,
   Charles/0000-0001-5476-5920
FU NCATS NIH HHS [UL1 TR000454] Funding Source: Medline; NIDDK NIH HHS [K08
   DK083036] Funding Source: Medline; NIMH NIH HHS [R01 MH071537, K23
   MH082256] Funding Source: Medline
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NR 58
TC 64
Z9 79
U1 0
U2 15
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0163-8343
EI 1873-7714
J9 GEN HOSP PSYCHIAT
JI Gen. Hosp. Psych.
PD MAR-APR
PY 2011
VL 33
IS 2
BP 135
EP 142
DI 10.1016/j.genhosppsych.2011.01.002
PG 8
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 745RP
UT WOS:000289183700007
PM 21596206
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Vitale, E
AF Vitale, Elsa
TI Correlations between Insomnia and Sex, Work Experience, Shift and Body
   Max Index in Italian Nurses: A Scoping Profile Statement
SO ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS
LA English
DT Article
DE Body mass index; insomnia; nurse; sex; shift work; workload
ID MENTAL-HEALTH STATUS; METABOLIC SYNDROME; MASS INDEX; HOSPITAL NURSES;
   ENERGY-INTAKE; CARDIOVASCULAR-DISEASE; PHYSICAL INACTIVITY; SEVERITY
   INDEX; MEAL FREQUENCY; HEART-DISEASE
AB Aim The present study aimed to assess any association existing between insomnia according to sex, work experience, shift and BMI values in Italian nurses. Methods An "ad hoc" questionnaire was created and administered online in October 2020. Data collected included: sex, years of work experience, shift work per day, BMI values, and insomnia levels. Findings A total of 341 Italian nurses were enrolled. Of these, 277 (81.23%) were females and n=64 (18.77%) males. No significant differences were assessed between ISI levels and sex, BMI scores, work experience and shift (p=.098; p=.978; p=.561; p=.222, respectively). Significant and inverse correlation was assessed between ISI values and sex (p=.019), BMI values (p=.033). While, no significant correlations were assessed between ISI levels and work experience (p=.805) and shift (p=.962), respectively. However, work experience reported significant correlations between BMI classes (p>.001) and shift (p<.001). Conclusion Data suggested potential health risk factors for the nursing workforce, associated with weight gain and developing Metabolic Syndrome. Therefore, the essence of the nursing profession could affect work performance and cause problems in the family and social life, as well as stress, anxiety, depression, fatigue, and irregular sleep patterns.
C1 [Vitale, Elsa] Local Hlth Author Bari, Ctr Mental Hlth Modugno, Via X Marzo 43, I-70026 Bari, Italy.
RP Vitale, E (corresponding author), Local Hlth Author Bari, Ctr Mental Hlth Modugno, Via X Marzo 43, I-70026 Bari, Italy.
EM vitaleelsa@libero.it
RI Vitale, Elsa/D-8904-2018
OI Vitale, Elsa/0000-0002-9738-3479
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NR 125
TC 3
Z9 3
U1 0
U2 6
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1871-5303
EI 2212-3873
J9 ENDOCR METAB IMMUNE
JI Endocr. Metab. Immune Disord.-Drug Targets
PY 2022
VL 22
IS 13
BP 1303
EP 1312
DI 10.2174/1871530322666220701095751
PG 10
WC Endocrinology & Metabolism; Immunology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Immunology; Pharmacology & Pharmacy
GA 7A9MU
UT WOS:000898771900008
PM 35786343
DA 2025-06-11
ER

PT J
AU Adewuya, AO
   Oladipo, O
   Ajomale, T
   Adewumi, T
   Momodu, O
   Olibamoyo, O
   Adesoji, O
   Adegbokun, A
   Adegbaju, D
AF Adewuya, Abiodun O.
   Oladipo, Olabisi
   Ajomale, Tolu
   Adewumi, Tomilola
   Momodu, Olufisayo
   Olibamoyo, Olushola
   Adesoji, Olabanji
   Adegbokun, Adedayo
   Adegbaju, Dapo
TI Epidemiology of depression in primary care: Findings from the Mental
   Health in Primary Care (MeHPriC) project, Lagos, Nigeria
SO INTERNATIONAL JOURNAL OF PSYCHIATRY IN MEDICINE
LA English
DT Article
DE rate; correlates; epidemiology; depression; primary care; Nigeria
ID ALCOHOL-RELATED PROBLEMS; SOCIAL SUPPORT; SCREENING TOOL; AGE;
   QUESTIONNAIRE; POPULATION; PREVALENCE; SEVERITY; SYMPTOMS; METAANALYSIS
AB Objective
   To estimate the rate and correlates of depression in primary care using data from the Mental Health in Primary Care (MeHPriC) project, Lagos, Nigeria.
   Methods
   Adult attendees (n=44,238) of 57 primary care facilities were evaluated for depression using the Patient Health Questionnaire (PHQ-9). Apart from the socio-demographic details, information was also collected regarding the use of alcohol and other psychoactive substances, presence of chronic medical problems, level of functionality, and perceived social support. Anthropometrics measures (weight and height) and blood pressure were also recorded.
   Results
   A total of 27,212 (61.5%) of the participants were females. There were 32,037 (72.4%) participants in the age group 25-60 years. The rate of major depression (PHQ-9 score 10 and above) was 15.0% (95% CI 14.6-15.3). The variables independently associated with depression include age 18-24 years (OR 1.69), female sex (OR 2.39), poor social support (OR 1.14), having at least one metabolic syndrome component (OR 1.57), significant alcohol use (OR 1.13) and functional disability (OR 1.38).
   Conclusion
   Our study showed that the rate of depression in primary care in Nigeria is high. Screening for all primary care attendees for depression will be an important step towards scaling up mental health services in Nigeria and other developing countries.
C1 [Adewuya, Abiodun O.; Olibamoyo, Olushola] Lagos State Univ, Coll Med, Dept Behav Med, Lagos, Nigeria.
   [Adewuya, Abiodun O.; Oladipo, Olabisi; Adewumi, Tomilola; Momodu, Olufisayo] Ctr Mental Hlth Res & Initiat, Lagos, Nigeria.
   [Ajomale, Tolu] Lagos State Minist Hlth, Mental Hlth Desk Off, Lagos, Nigeria.
   [Momodu, Olufisayo; Adesoji, Olabanji; Adegbokun, Adedayo] Lagos State Minist Hlth, Hlth Serv Commiss, Lagos, Nigeria.
   [Adegbaju, Dapo] Fed Neuropsychiat Hosp, Lagos, Nigeria.
C3 Lagos State University
RP Adewuya, AO (corresponding author), Lagos State Univ, Coll Med, Dept Behav Med, Lagos, Nigeria.
EM abiodun.adewuya@lasucom.edu.ng
RI Olibamoyo, Olushola/ABC-8818-2020; ADEWUYA, Abiodun
   Olugbenga/N-4997-2017
OI Oladipo, Olabisi Eniola/0000-0001-7284-7743; Olibamoyo,
   Olushola/0000-0001-9696-029X; ADEWUYA, Abiodun
   Olugbenga/0000-0002-7611-6953
FU Grand Challenges Canada [0796-05]; MRC [MR/T021845/1] Funding Source:
   UKRI
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: This work
   was supported by Grand Challenges Canada (grant no. 0796-05).
CR Abiola T., 2013, Malaysian J Psychiatry, V22, P32
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NR 46
TC 2
Z9 2
U1 0
U2 5
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0091-2174
EI 1541-3527
J9 INT J PSYCHIAT MED
JI Int. J. Psychiatr. Med.
PD JAN
PY 2022
VL 57
IS 1
BP 6
EP 20
AR 0091217421996089
DI 10.1177/0091217421996089
EA FEB 2021
PG 15
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA XN5LT
UT WOS:000619956100001
PM 33573444
DA 2025-06-11
ER

PT J
AU Stanton, R
   Gaskin, CJ
   Happell, B
   Platania-Phung, C
AF Stanton, Robert
   Gaskin, Cadeyrn J.
   Happell, Brenda
   Platania-Phung, Chris
TI The need for waist circumference as a criterion for metabolic syndrome
   in people with mental illness
SO COLLEGIAN
LA English
DT Article
DE Cardiometabolic health; Mental health; Metabolic health; Monitoring;
   Physical health
ID PHYSICAL HEALTH-CARE; CONSUMERS; NURSES; PREVALENCE; DISORDERS; RISK
AB Central obesity is a risk factor for metabolic syndrome, but taking waist circumference measurements can be uncomfortable for psychiatric inpatient clinicians and consumers, and if often avoided. The objective of this study was to assess whether metabolic syndrome in people with mental illness can be diagnosed without using waist circumference measurements. This study involved a retrospective file audit of metabolic monitoring forms stored in consumers' electronic health records of community-based and inpatient mental health consumers at a mental health service located in regional Queensland, Australia. Of the 721 consumer files audited, 261 included a metabolic monitoring form. Of these 261 forms, 74 contained data on all five criteria for metabolic syndrome and the population-specific criteria for waist circumference was met in 54 (73%) of cases. Metabolic syndrome was detected in 39 consumers and waist circumference was necessary for this diagnosis in 12 (31%) cases. Measurement of waist circumference is, therefore, necessary for the detection of metabolic syndrome for a substantial proportion of consumers. The common practice of avoiding waist circumference measurements clearly needs to change if the physical health needs of consumers are to be adequately addressed. (C) 2016 Australian College of Nursing Ltd. Published by Elsevier Ltd.
C1 [Stanton, Robert; Gaskin, Cadeyrn J.] Cent Queensland Univ, Sch Med & Appl Sci, Rockhampton, Qld, Australia.
   [Gaskin, Cadeyrn J.] Gaskin Res, Melbourne, Vic, Australia.
   [Happell, Brenda] Univ Canberra, SYNERGY Nursing & Midwifery Res Ctr, Canberra, ACT, Australia.
   [Happell, Brenda; Platania-Phung, Chris] ACT Hlth, Canberra, ACT, Australia.
   [Platania-Phung, Chris] Univ Canberra, Fac Hlth, SYNERGY Nursing & Midwifery Res Ctr, Canberra, ACT, Australia.
C3 Central Queensland University; University of Canberra; ACT Health
   Australia; University of Canberra
RP Stanton, R (corresponding author), Cent Queensland Univ, Sch Med & Appl Sci, Bruce Highway, North Rockhampton, Qld 4702, Australia.
EM r.stanton@cqu.edu.au
RI Stanton, Rob/AAJ-5157-2020; Happell, Brenda/HSI-0570-2023
OI Gaskin, Cadeyrn/0000-0001-5240-4320; Stanton,
   Robert/0000-0002-6684-5087; Happell, Brenda/0000-0002-7293-6583
FU Queensland Centre for Social Science Innovation; Central Queensland
   Mental Health Service
FX The authors acknowledge the funding provided by the (former) Queensland
   Centre for Social Science Innovation.Special thanks to Central
   Queensland Mental Health Service for their support of the research, and
   particularly to Karen-Lee O'Brien for undertaking the data entry.
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NR 30
TC 4
Z9 4
U1 0
U2 2
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1322-7696
EI 1876-7575
J9 COLLEGIAN
JI Collegian
PY 2017
VL 24
IS 4
BP 387
EP 390
DI 10.1016/j.colegn.2016.08.005
PG 4
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA FB4GI
UT WOS:000406099300010
DA 2025-06-11
ER

PT J
AU Moreira, FP
   Jansen, K
   Cardoso, TD
   Mondin, TC
   Vieira, IS
   Magalhaes, PVD
   Kapczinski, F
   Souza, LDD
   da Silva, RA
   Oses, JP
   Wiener, CD
AF Moreira, Fernanda Pedrotti
   Jansen, Karen
   Cardoso, Taiane de Azevedo
   Mondin, Thaise Campos
   Vieira, Igor Soares
   da Silva Magalhaes, Pedro Vieira
   Kapczinski, Flavio
   de Mattos Souza, Luciano Dias
   da Silva, Ricardo Azevedo
   Oses, Jean Pierre
   Wiener, Carolina David
TI Metabolic syndrome, depression and anhedonia among young adults
SO PSYCHIATRY RESEARCH
LA English
DT Article
DE Depression; Anhedonia; Metabolic syndrome
ID BIOLOGICAL RHYTHMS; GENDER-DIFFERENCES; DISORDER; METAANALYSIS;
   COMMUNITY; BIPOLAR; STRESS; ASSOCIATION; PREVALENCE; MORTALITY
AB The aim of this study was to assess the association between anhedonia and metabolic syndrome (MetS) in a well-characterized community sample of individuals with a current depressive episode. This is a cross-sectional study with young adults aged 24-30 years old. Depressive episode and the presence of anhedonia was assessed using the Mini International Neuropsychiatric Interview - Plus version (MINI Plus). The MetS was assessed using the National Cholesterol Education Program Adult Treatment Panel III (NCEP/ATP III). The sample included 931 subjects, being 22 had depression without anhedonia, whereas 55 had depression with anhedonia. MetS was more prevalent among subjects with depression and anhedonia (43.6%) when compared to individuals without anhedonia and population control group. Moreover, subjects with depression and anhedonia have a significant increase of levels of glucose, triglycerides, total-cholesterol and LDL-cholesterol, as well as significant decreased in the HDL-cholesterol level. The present study showed that individuals with depression and anhedonia present higher prevalence of MetS. Our study suggests that the use of the concept of anhedonia may contribute to a better understanding of the complex relationship between depression and metabolic syndrome.
C1 [Moreira, Fernanda Pedrotti; Jansen, Karen; Mondin, Thaise Campos; Vieira, Igor Soares; de Mattos Souza, Luciano Dias; da Silva, Ricardo Azevedo; Oses, Jean Pierre; Wiener, Carolina David] Univ Catolica Pelotas, Dept Hlth & Behav, Translat Sci Brain Disorders, Pelotas, RS, Brazil.
   [Jansen, Karen; Cardoso, Taiane de Azevedo; da Silva Magalhaes, Pedro Vieira; Kapczinski, Flavio] Univ Fed Rio Grande do Sul, Dept Psychiat & Behav Sci, Mol Psychiat, Porto Alegre, RS, Brazil.
   [Kapczinski, Flavio] McMaster Univ, Hamilton, ON, Canada.
   [Wiener, Carolina David] Univ Fed Pelotas, Dept Epidemiol, Pelotas, RS, Brazil.
C3 Universidade Catolica de Pelotas; Universidade Federal de Pelotas;
   Universidade Federal do Rio Grande do Sul; McMaster University;
   Universidade Federal de Pelotas
RP Jansen, K (corresponding author), Univ Catolica Pelotas, Dept Hlth & Behav, Translat Sci Brain Disorders, Pelotas, RS, Brazil.
EM karen.jansen@pq.cnpq.br
RI Cardoso, Taiane/K-1980-2015; Pedrotti Moreira, Fernanda/JRX-8306-2023;
   Oses, Jean/E-2534-2013; Magalhaes, Pedro/A-8519-2008; Jansen,
   Karen/O-3128-2015; Kapczinski, Flavio/D-3175-2013
OI Magalhaes, Pedro/0000-0002-5644-6357; Soares Vieira,
   Igor/0000-0002-3263-8397; Dias de Mattos Souza,
   Luciano/0000-0001-9965-4837; Oses, Jean Pierre/0000-0002-2012-273X;
   Jansen, Karen/0000-0003-3494-8070; Pedrotti Moreira,
   Fernanda/0000-0002-3672-7231; Kapczinski, Flavio/0000-0001-8738-856X
FU Brazilian governamental agency: Coordenacao de Aperfeicoamento de
   Pessoal de Nivel Superior (CAPES); Brazilian governamental agency:
   Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq);
   Brazilian governamental agency: Fundacao de Amparo a Pesquisa do Estado
   do Rio Grande do Sul (FAPERGS)
FX Support for this study was provided by Brazilian governamental agencies:
   Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES),
   Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) and
   Fundacao de Amparo a Pesquisa do Estado do Rio Grande do Sul (FAPERGS).
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NR 39
TC 41
Z9 46
U1 1
U2 23
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0165-1781
J9 PSYCHIAT RES
JI Psychiatry Res.
PD JAN
PY 2019
VL 271
BP 306
EP 310
DI 10.1016/j.psychres.2018.08.009
PG 5
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA HO1YZ
UT WOS:000460709900048
PM 30522000
DA 2025-06-11
ER

PT J
AU Wilhite, K
   Booker, B
   Huang, BH
   Antczak, D
   Corbett, L
   Parker, P
   Noetel, M
   Rissel, C
   Lonsdale, C
   Cruz, BD
   Sanders, T
AF Wilhite, Katrina
   Booker, Bridget
   Huang, Bo-Huei
   Antczak, Devan
   Corbett, Lucy
   Parker, Philip
   Noetel, Michael
   Rissel, Chris
   Lonsdale, Chris
   Cruz, Borja del Pozo
   Sanders, Taren
TI Combinations of Physical Activity, Sedentary Behavior, and Sleep
   Duration and Their Associations With Physical, Psychological, and
   Educational Outcomes in Children and Adolescents: A Systematic Review
SO AMERICAN JOURNAL OF EPIDEMIOLOGY
LA English
DT Review
DE adolescents; children; physical activity; sedentary behavior; sleep
ID 24-HOUR MOVEMENT GUIDELINES; QUALITY-OF-LIFE; CARDIOMETABOLIC
   RISK-FACTORS; POPULATION-BASED SAMPLE; SCHOOL-AGED CHILDREN; SCREEN
   TIME; CARDIORESPIRATORY FITNESS; ACADEMIC-ACHIEVEMENT; MENTAL-HEALTH;
   EUROPEAN ADOLESCENTS
AB We conducted a systematic review to evaluate combinations of physical activity, sedentary behavior, and sleep duration (defined as "movement behaviors") and their associations with physical, psychological, and educational outcomes in children and adolescents. MEDLINE, CINAHL, PsychInfo, SPORTDiscus, PubMed, EMBASE, and ERIC were searched in June 2020. Included studies needed to 1) quantitatively analyze the association of 2 or more movement behaviors with an outcome, 2) analyze a population between 5 and 17 years of age, and 3) include at least an English abstract. We included 141 studies. Most studies included the combination of physical activity and sedentary behavior in their analyses. Sleep was studied less frequently. In combination, a high level of physical activity and a low level of sedentary behavior were associated with the best physical health, psychological health, and education-related outcomes. Sleep was often included in the combination that was associated with the most favorable outcomes. Sedentary behavior had a stronger influence in adolescents than in children and tended to be associated more negatively with outcomes when it was defined as screen time than when defined as overall time spent being sedentary. More initiatives and guidelines combining all 3 movement behaviors will provide benefit with regard to adiposity, cardiometabolic risk factors, cardiorespiratory fitness, muscular physical fitness, well-being, health-related quality of life, mental health, academic performance, and cognitive/executive function.
C1 [Sanders, Taren] Australian Catholic Univ, Inst Posit Psychol & Educ, Fac Hlth Sci, 33 Berry St, North Sydney, NSW 2066, Australia.
   [Wilhite, Katrina; Booker, Bridget; Parker, Philip; Lonsdale, Chris; Sanders, Taren] Australian Catholic Univ, Inst Posit Psychol & Educ, Fac Hlth Sci, North Sydney, NSW, Australia.
   [Huang, Bo-Huei] Univ Sydney, Fac Med & Hlth, Charles Perkins Ctr, Sch Hlth Sci, Sydney, NSW, Australia.
   [Antczak, Devan] Univ Wollongong, Fac Social Sci, Sch Educ, Wollongong, NSW, Australia.
   [Corbett, Lucy] Univ Sydney, Fac Med & Hlth Sci, Sch Publ Hlth, Sydney, NSW, Australia.
   [Noetel, Michael] Australian Catholic Univ, Inst Posit Psychol & Educ, Fac Hlth Sci, Sch Behav & Hlth Sci, North Sydney, NSW, Australia.
   [Rissel, Chris] Flinders Univ S Australia, Coll Med & Publ Hlth, Flinders Northern Terr, Bedford Pk, SA, Australia.
   [Cruz, Borja del Pozo] Univ Southern Denmark, Fac Hlth Sci, Dept Sport Sci & Clin Biomech, Ctr Act & Hlth Aging, Odense, Denmark.
C3 Australian Catholic University; Australian Catholic University - North
   Sydney Campus; Australian Catholic University; Australian Catholic
   University - North Sydney Campus; University of Sydney; University of
   Wollongong; University of Sydney; Australian Catholic University;
   Australian Catholic University - North Sydney Campus; Flinders
   University South Australia; University of Southern Denmark
RP Sanders, T (corresponding author), Australian Catholic Univ, Inst Posit Psychol & Educ, Fac Hlth Sci, 33 Berry St, North Sydney, NSW 2066, Australia.
EM katrina.wilhite@acu.edu.au; bridget.booker@acu.edu.au;
   bhua7802@uni.sydney.edu.au; devan@uow.edu.au;
   lucy.corbett@sydney.edu.au; philip.parker@acu.edu.au;
   michael.noetel@acu.edu.au; chris.rissel@flinders.edu.au;
   chris.lonsdale@acu.edu.au; bdelpozocruz@health.sdu.dk;
   taren.sanders@acu.edu.au
RI Noetel, Michael/I-4534-2019; Rissel, Chris/ABA-5881-2020; Corbett,
   Lucy/AHB-2418-2022; Parker, Philip/K-2896-2018; Huang,
   Bo-Huei/ABD-7382-2020; Lonsdale, Chris/T-8710-2017; Sanders,
   Taren/N-9511-2018; del Pozo Cruz, Borja/IAM-4325-2023
OI Booker, Bridget/0000-0002-8815-7314; Lonsdale,
   Chris/0000-0002-2523-5565; Huang, Bo-Huei/0000-0001-8543-3152; Rissel,
   Chris/0000-0002-2156-8581; Sanders, Taren/0000-0002-4504-6008; Corbett,
   Lucy/0000-0002-6324-4489; del Pozo Cruz, Borja/0000-0003-3944-2212
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NR 176
TC 71
Z9 75
U1 22
U2 126
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0002-9262
EI 1476-6256
J9 AM J EPIDEMIOL
JI Am. J. Epidemiol.
PD APR 6
PY 2023
VL 192
IS 4
BP 665
EP 679
DI 10.1093/aje/kwac212
EA DEC 2022
PG 15
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA C9LQ9
UT WOS:000931051900001
PM 36516992
OA hybrid, Green Published
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Everding, B
   Hallam, JE
   Kohut, ML
   Lee, DC
   Anderson, AA
   Franke, WD
AF Everding, Braden
   Hallam, Justus E.
   Kohut, Marian L.
   Lee, Duck-chul
   Anderson, Amanda A.
   Franke, Warren D.
TI Association of Sleep Quality With Cardiovascular Disease Risk and Mental
   Health in Law Enforcement Officers
SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
LA English
DT Article
ID ISCHEMIC-HEART-DISEASE; METABOLIC SYNDROME; POLICE OFFICERS;
   INFLAMMATORY MARKERS; ATHEROSCLEROSIS; BIOMARKERS; POPULATION;
   PREDICTION; CHEMOKINES; DISORDERS
AB Objectives: The aim of the study was to determine whether sleep quality is associated with an increased risk for cardiovascular disease (CVD) or worsened mental health. Methods: Self-reported sleep quality, 35 inflammatory factors, CVD risk factors, personal stress, police operational and organizational stress, social support, depressive symptoms, and health-related quality of life were compared among a cohort of officers. Results: Of 379 officers, 39% and 27% had poor and borderline sleep quality. Sleep quality was not associated with either an altered inflammatory profile or worsened CVD risk factors. Compared with good sleepers, borderline and poor sleepers reported increased personal stress, police organizational and operational stress, and depressive symptoms, but decreased health-related quality of life. Conclusions: Poor sleep quality is prevalent in the law enforcement profession and is associated with worsened mental health but not with an increased risk for CVD.
C1 [Everding, Braden; Hallam, Justus E.; Kohut, Marian L.; Lee, Duck-chul; Anderson, Amanda A.; Franke, Warren D.] Iowa State Univ, Dept Kinesiol, 247 Forker Bldg, Ames, IA 50011 USA.
C3 Iowa State University
RP Franke, WD (corresponding author), Iowa State Univ, Dept Kinesiol, 247 Forker Bldg, Ames, IA 50011 USA.
EM wfranke@iastate.edu
CR Amendola KL, 2012, 237330 US DEP JUST N
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NR 46
TC 16
Z9 19
U1 2
U2 12
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1076-2752
EI 1536-5948
J9 J OCCUP ENVIRON MED
JI J. Occup. Environ. Med.
PD AUG
PY 2016
VL 58
IS 8
BP E281
EP E286
DI 10.1097/JOM.0000000000000814
PG 6
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA DT0DP
UT WOS:000381153200001
PM 27414012
DA 2025-06-11
ER

PT J
AU Root, AL
   Crossley, NP
   Heck, JL
   Mccage, S
   Proulx, J
   Jones, EJ
AF Root, Andrea L.
   Crossley, Nicole P.
   Heck, Jennifer L.
   Mccage, Shondra
   Proulx, Jeffrey
   Jones, Emily J.
TI Effects of Mindfulness-Based Interventions on Cardiometabolic-Related
   Adverse Pregnancy Outcomes
SO JOURNAL OF CARDIOVASCULAR NURSING
LA English
DT Article
DE cardiometabolic risk factors; cardiovascular pregnancy complications;
   mindfulness
ID CARDIOVASCULAR-DISEASE RISK; SCIENTIFIC STATEMENT; STRESS REDUCTION;
   PREVENTION; WOMEN; HEALTH; IMPACT
AB BackgroundGrowing evidence suggests maternal stress contributes to the development of adverse pregnancy outcomes that are associated with cardiovascular and cardiometabolic risk in birthing persons. Mindfulness-based interventions may positively affect psychological stress in pregnancy and, in turn, reduce stress. However, few study authors have examined the effects of mindfulness-based interventions on adverse pregnancy outcomes that heighten cardiovascular risk.ObjectiveThe aim of this study was to appraise available literature examining the effects of mindfulness-based interventions delivered during pregnancy on adverse pregnancy outcomes associated with future cardiovascular and cardiometabolic disease risk.MethodsIn this systematic review, multiple electronic databases were searched using major keywords, including "mindfulness-based intervention," "pregnancy," "preterm delivery," "gestational diabetes," "small for gestational age," "preeclampsia," and "hypertension in pregnancy" during February 2023.ResultsSix studies using mindfulness-based interventions during pregnancy were included. The review indicated that these interventions were largely effective at reducing prenatal stress; however, the overall effects of interventions were mixed concerning their impact on pregnancy complications. Study authors examining the effects on gestational diabetes-related outcomes reported significant improvements in blood glucose levels, hemoglobin A1c, and oral glucose tolerance. Outcomes were mixed or inconclusive related to the effects of interventions on the incidence of preterm birth, birth of a small-for-gestational-age newborn, and preeclampsia.ConclusionsMitigating cardiovascular and cardiometabolic risk-associated adverse pregnancy outcomes through mindfulness-based approaches may represent an emerging field of study. The few studies and limited, mixed findings synthesized in this review indicate that high-validity studies are warranted to examine the effects of mindfulness-based interventions on pregnancy complications that contribute to cardiovascular-related maternal morbidity and suboptimal life course health for diverse birthing persons.
C1 [Root, Andrea L.; Crossley, Nicole P.; Heck, Jennifer L.; Jones, Emily J.] Univ Oklahoma Hlth Sci Ctr, Fran & Earl Ziegler Coll Nursing, 1100 N Stonewall Ave, Oklahoma City, OK 73117 USA.
   [Mccage, Shondra] Univ Oklahoma Hlth Sci Ctr, Hudson Coll Publ Hlth, Oklahoma City, OK USA.
   [Proulx, Jeffrey] Brown Univ, Sch Publ Hlth, Fran & Earl Ziegler Coll Nursing, Providence, RI USA.
C3 University of Oklahoma System; University of Oklahoma Health Sciences
   Center; University of Oklahoma System; University of Oklahoma Health
   Sciences Center; Brown University
RP Root, AL (corresponding author), Univ Oklahoma Hlth Sci Ctr, Fran & Earl Ziegler Coll Nursing, 1100 N Stonewall Ave, Oklahoma City, OK 73117 USA.
EM ndrea-root@ouhsc.edu; Nicole-crossley@ouhsc.edu;
   Jennifer-heck@ouhsc.edu; shondra.mccage@chickasaw.net;
   Jeffrey_Proulx@brown.edu; Emily-j-jones@ouhsc.edu
OI Root, Andrea/0000-0002-4640-1075; Crossley, Nicole/0000-0003-2615-7463
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NR 59
TC 1
Z9 1
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0889-4655
EI 1550-5049
J9 J CARDIOVASC NURS
JI J. Cardiovasc. Nurs.
PD JUL-AUG
PY 2024
VL 39
IS 4
BP 335
EP 346
DI 10.1097/JCN.0000000000001054
PG 12
WC Cardiac & Cardiovascular Systems; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Cardiovascular System & Cardiology; Nursing
GA TM2P5
UT WOS:001241616700004
PM 37878581
OA Bronze
DA 2025-06-11
ER

PT J
AU Scott, EM
   Carpenter, JS
   Iorfino, F
   Cross, SPM
   Hermens, DF
   Gehue, J
   Wilson, C
   White, D
   Naismith, SL
   Guastella, AJ
   Hickie, IB
AF Scott, Elizabeth M.
   Carpenter, Joanne S.
   Iorfino, Frank
   Cross, Shane P. M.
   Hermens, Daniel F.
   Gehue, Jeanne
   Wilson, Chloe
   White, Django
   Naismith, Sharon L.
   Guastella, Adam J.
   Hickie, Ian B.
TI What is the prevalence, and what are the clinical correlates, of insulin
   resistance in young people presenting for mental health care? A
   cross-sectional study
SO BMJ OPEN
LA English
DT Article
ID MAJOR DEPRESSIVE DISORDER; HOMEOSTASIS MODEL ASSESSMENT; PSYCHOSOCIAL
   RISK-FACTORS; BETA-CELL FUNCTION; METABOLIC SYNDROME; PHYSICAL-ACTIVITY;
   BIPOLAR DISORDER; CARDIOMETABOLIC RISK; 2ND-GENERATION ANTIPSYCHOTICS;
   PSYCHOTIC DISORDERS
AB Objectives To report the distribution and predictors of insulin resistance (IR) in young people presenting to primary care-based mental health services.
   Design Cross-sectional.
   Setting Headspace-linked clinics operated by the Brain and Mind Centre of the University of Sydney.
   Participants 768 young people (66% female, mean age 19.7 +/- 3.5, range 12-30 years).
   Main outcome measures IR was estimated using the updated homeostatic model assessment (HOMA2-IR). Height and weight were collected from direct measurement or self-report for body mass index (BMI).
   Results For BMI, 20.6% of the cohort were overweight and 10.2% were obese. However, <1% had an abnormally high fasting blood glucose (>6.9 mmol/L). By contrast, 9.9% had a HOMA2-IR score >2.0 (suggesting development of IR) and 11.7% (n=90) had a score between 1.5 and 2. Further, there was a positive correlation between BMI and HOMA2-IR (r=0.44, p<0.001). Participants in the upper third of HOMA2-IR scores are characterised by younger age, higher BMIs and depression as a primary diagnosis. HOMA2-IR was predicted by younger age (beta=0.19, p<0.001) and higher BMI (beta=0.49, p<0.001), together explaining 22% of the variance (F-(2,F-361)=52.1, p<0.001).
   Conclusions Emerging IR is evident in a significant subgroup of young people presenting to primary care-based mental health services. While the major modifiable risk factor is BMI, a large proportion of the variance is not accounted for by other demographic, clinical or treatment factors. Given the early emergence of IR, secondary prevention interventions may need to commence prior to the development of full-threshold or major mood or psychotic disorders.
C1 [Scott, Elizabeth M.; Carpenter, Joanne S.; Iorfino, Frank; Cross, Shane P. M.; Hermens, Daniel F.; Gehue, Jeanne; Wilson, Chloe; White, Django; Naismith, Sharon L.; Guastella, Adam J.; Hickie, Ian B.] Univ Sydney, Brain & Mind Ctr, Sydney, NSW, Australia.
   [Scott, Elizabeth M.] Univ Notre Dame, Sch Med, Sydney, NSW, Australia.
   [Hermens, Daniel F.] Sunshine Coast Mind & Neurosci Thompson Inst, Birtinya, Qld, Australia.
C3 University of Sydney; The University of Notre Dame Australia
RP Hickie, IB (corresponding author), Univ Sydney, Brain & Mind Ctr, Sydney, NSW, Australia.
EM ian.hickie@sydney.edu.au
RI Guastella, Adam/JCE-9327-2023; Iorfino, Frank/AAD-8492-2021; Carpenter,
   Joanne/HZK-3629-2023; Hickie, Ian/K-8975-2015
OI Naismith, Sharon/0000-0001-9076-2778; Carpenter,
   Joanne/0000-0002-9766-6700; Scott, Elizabeth/0000-0003-3907-0324; Cross,
   Shane/0000-0002-5413-8342; Hermens, Daniel/0000-0002-8570-2663; Iorfino,
   Frank/0000-0003-1109-0972; Hickie, Ian/0000-0001-8832-9895; Guastella,
   Adam/0000-0001-8178-4625
FU National Health and Medical Research Council (NHMRC) including Centre of
   Research Excellence [1061043]; National Health and Medical Research
   Council (NHMRC) including Australia Fellowship [511921]; National Health
   and Medical Research Council (NHMRC) including Clinical Research
   Fellowship [402864]
FX This work was partially supported by grants from the National Health and
   Medical Research Council (NHMRC) including Centre of Research Excellence
   (No. 1061043), Australia Fellowship (No. 511921 awarded to IBH) and
   Clinical Research Fellowship (No. 402864 awarded to SLN).
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NR 60
TC 15
Z9 16
U1 0
U2 1
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2044-6055
J9 BMJ OPEN
JI BMJ Open
PD MAY
PY 2019
VL 9
IS 5
AR e025674
DI 10.1136/bmjopen-2018-025674
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA IC7YG
UT WOS:000471192800136
PM 31138580
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Pervanidou, P
   Chrousos, GP
AF Pervanidou, Panagiota
   Chrousos, George P.
TI Metabolic consequences of stress during childhood and adolescence
SO METABOLISM-CLINICAL AND EXPERIMENTAL
LA English
DT Review
ID PITUITARY-ADRENAL AXIS; SHORT-SLEEP DURATION; MOTOR-VEHICLE ACCIDENTS;
   HYPOTHALAMIC AMENORRHEA; CORTISOL CONCENTRATIONS; EMOTIONAL-STRESS;
   HUMAN PHYSIOLOGY; TELOMERE LENGTH; DEPRESSION; LEPTIN
AB Stress, that is, the state of threatened or perceived as threatened homeostasis, is associated with activation of the stress system, mainly comprised by the hypothalamic-pituitary-adrenal axis and the arousal/sympathetic nervous systems. The stress system normally functions in a circadian manner and interacts with other systems to regulate a variety of behavioral, endocrine, metabolic, immune, and cardiovascular functions. However, the experience of acute intense physical or emotional stress, as well as of chronic stress, may lead to the development of or may exacerbate several psychologic and somatic conditions, including anxiety disorders, depression, obesity, and the metabolic syndrome. In chronically stressed individuals, both behavioral and neuroendocrine mechanisms promote obesity and metabolic abnormalities: unhealthy lifestyles in conjunction with dysregulation of the stress system and increased secretion of cortisol, catecholamines, and interleukin-6, with concurrently elevated insulin concentrations, lead to development of central obesity, insulin resistance, and the metabolic syndrome. Fetal life, childhood, and adolescence are particularly vulnerable periods of life to the effects of intense acute or chronic stress. Similarly, these life stages are crucial for the later development of behavioral, metabolic, and immune abnormalities. Developing brain structures and functions related to stress regulation, such as the amygdala, the hippocampus, and the mesocorticolimbic system, are more vulnerable to the effects of stress compared with mature structures in adults. Moreover, chronic alterations in cortisol secretion in children may affect the timing of puberty, final stature, and body composition, as well as cause early-onset obesity, metabolic syndrome, and type 2 diabetes mellitus. The understanding of stress mechanisms leading to metabolic abnormalities in early life may lead to more effective prevention and intervention strategies of obesity-related health problems. (C) 2012 Elsevier Inc. All rights reserved.
C1 [Pervanidou, Panagiota; Chrousos, George P.] Univ Athens, Sch Med, Dept Pediat 1, Aghia Sophia Childrens Hosp, GR-11527 Athens, Greece.
C3 Athens Medical School; National & Kapodistrian University of Athens; The
   Aghia Sophia Children's Hospital
RP Pervanidou, P (corresponding author), Univ Athens, Sch Med, Dept Pediat 1, Aghia Sophia Childrens Hosp, GR-11527 Athens, Greece.
EM ppervanid@med.uoa.gr
RI Chrousos, George/G-8702-2011; Pervanidou, Panagiota/ABI-6356-2020
OI Pervanidou, Panagiota/0000-0002-6593-6489
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NR 93
TC 245
Z9 277
U1 1
U2 82
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0026-0495
EI 1532-8600
J9 METABOLISM
JI Metab.-Clin. Exp.
PD MAY
PY 2012
VL 61
IS 5
BP 611
EP 619
DI 10.1016/j.metabol.2011.10.005
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 936VH
UT WOS:000303617600002
PM 22146091
DA 2025-06-11
ER

PT J
AU Clausing, ES
   Non, AL
AF Clausing, Elizabeth S.
   Non, Amy L.
TI Epigenetics as a Mechanism of Developmental Embodiment of Stress,
   Resilience, and Cardiometabolic Risk Across Generations of Latinx
   Immigrant Families
SO FRONTIERS IN PSYCHIATRY
LA English
DT Article
DE epigenetic; embodiment; stress; resilience (psychological); Latinx;
   maternal and child health; cardiometabolic health
ID DNA METHYLATION; SOCIOECONOMIC-STATUS; WAIST CIRCUMFERENCE;
   UNITED-STATES; EVERYDAY DISCRIMINATION; ACCULTURATIVE STRESS;
   AFRICAN-AMERICAN; MATERNAL STRESS; HEALTH; DEPRESSION
AB Psychosocial stressors can become embodied to alter biology throughout the life course in ways that may have lasting health consequences. Immigrants are particularly vulnerable to high burdens of stress, which have heightened in the current sociopolitical climate. This study is an investigation of how immigration-related stress (IRS) may impact the cardiometabolic risk and epigenetic markers of Latinx immigrant mothers and children in Nashville, TN. We compared stress and resilience factors reported by Latina immigrant mothers and their children (aged 5-13) from two time points spanning the 2016 U.S. presidential election (June 2015-June 2016 baseline, n = 81; March-September 2018 follow-up, n = 39) with cardiometabolic risk markers (BMI, waist circumference, and blood pressure). We also analyzed these factors in relation to DNA methylation in saliva of stress-related candidate genes (SLC6A4 and FKBP5), generated via bisulfite pyrosequencing (complete case n's range from 67-72 baseline and 29-31 follow-up) (n's range from 80 baseline to 36 follow-up). We found various associations with cardiometabolic risk, such as higher social support and greater acculturation were associated with lower BMI in mothers; discrimination and school stress associated with greater waist circumferences in children. Very few exposures associated with FKBP5, but various stressors associated with methylation at many sites in SLC6A4, including immigrant-related stress in both mothers and children, and fear of parent deportation in children. Additionally, in the mothers, total maternal stress, health stress, and subjective social status associated with methylation at multiple sites of SLC6A4. Acculturation associated with methylation in mothers in both genes, though directions of effect varied over time. We also find DNA methylation at SLC6A4 associates with measures of adiposity and blood pressure, suggesting that methylation may be on the pathway linking stress with cardiometabolic risk. More research is needed to determine the role of these epigenetic differences in contributing to embodiment of stress across generations.
C1 [Clausing, Elizabeth S.; Non, Amy L.] Univ Calif San Diego UCSD, Dept Anthropol, La Jolla, CA 92093 USA.
C3 University of California System; University of California San Diego
RP Non, AL (corresponding author), Univ Calif San Diego UCSD, Dept Anthropol, La Jolla, CA 92093 USA.
EM alnon@ucsd.edu
RI Non, Amy/AAW-7116-2021
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NR 83
TC 11
Z9 12
U1 0
U2 8
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-0640
J9 FRONT PSYCHIATRY
JI Front. Psychiatry
PD JUL 20
PY 2021
VL 12
AR 696827
DI 10.3389/fpsyt.2021.696827
PG 14
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA XJ6IE
UT WOS:000726888300001
PM 34354616
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Kizilay, DÖ
   Sapmaz, SY
   Sen, S
   Özkan, Y
   Ersoy, B
AF Kizilay, Deniz Ozalp
   Sapmaz, Sermin Yalin
   Sen, Semra
   Ozkan, Yekta
   Ersoy, Betal
TI Insulin Resistance as Related to Psychiatric Disorders in Obese Children
SO JOURNAL OF CLINICAL RESEARCH IN PEDIATRIC ENDOCRINOLOGY
LA English
DT Article
DE Child; obesity; insulin resistance; mental disorder
ID NATIONALLY REPRESENTATIVE SAMPLE; METABOLIC SYNDROME; CHILDHOOD OBESITY;
   DEPRESSIVE SYMPTOMS; PHYSICAL-ACTIVITY; MENTAL-HEALTH; ANXIETY;
   ADOLESCENTS; OVERWEIGHT; RISK
AB Objective: The current study aimed to investigate psychiatric consequences of obesity and the relationship between componenets of the metabolic syndrome and psychiatric disorders in children. Our second aim was to elucidate which of the anthropometric parameters or metabolic components were most strongly associated with psychiatric disorders.
   Methods: The study included 88 obese and overweight children with a body mass index (BMI) greater than 85th percentile. The patients were evaluated for psychiatric disorders by a single child and adolescent psychiatrist. Forty patients diagnosed with psychiatric disorders and 48 patients with normal psychiatric evaluation were compared in terms of anthropometric and metabolic parameters. BMI, BMI-standard deviation score and BMI percentile, waist circumference, waist to hip ratio, blood pressure and pubertal stage of all patients were recorded. Fasting serum glucose, insulin, lipid profile and homeostatic model assessments of insulin resistance (HOMA-IR) were measured to evaluate the metabolic parameters. Serum and 24 hour urine cortisol levels were measured.
   Results: HOMA-IR in the group with psychiatric disorders was found to be significantly higher than in the group without psychiatric disorders (6.59 +/- 3.36 vs 5.21 +/- 2.67; p = 0.035). Other anthropometric measurements and metabolic parameters were not significantly different between the two groups.
   Conclusion: An understanding of the relationships between obesity related medical comorbidities and psychiatric pathologies is important to encourage patients and their families to make successful healthy lifestyle changes and for weight management in terms of appropriate treatment.
C1 [Kizilay, Deniz Ozalp] Cigli State Training Hosp, Clin Pediat, Div Pediat Endocrinol, Izmir, Turkey.
   [Sapmaz, Sermin Yalin; Ozkan, Yekta] Manisa Celal Bayar Univ, Fac Med, Dept Child & Adolescent Psychiat, Manisa, Turkey.
   [Sen, Semra] Manisa Celal Bayar Univ, Fac Med, Dept Pediat, Div Pediat Infect Dis, Manisa, Turkey.
   [Ersoy, Betal] Manisa Celal Bayar Univ, Fac Med, Dept Pediat, Div Pediat Endocrinol & Metab, Manisa, Turkey.
C3 Celal Bayar University; Celal Bayar University; Celal Bayar University
RP Sen, S (corresponding author), Manisa Celal Bayar Univ, Fac Med, Dept Pediat, Div Pediat Infect Dis, Manisa, Turkey.
EM drsemrasen@gmail.com
RI Ozkan, Yekta/GZK-9051-2022
OI Ozkan, Yekta/0000-0003-2220-9967
CR [Anonymous], 2002, HEALTH-LONDON
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NR 48
TC 3
Z9 3
U1 0
U2 3
PU GALENOS YAYINCILIK
PI FINDIKZADE
PA MOLLA GURANI MAHALLESI KACAMAK SOKAK NO 21, FINDIKZADE, ISTANBUL 34093,
   TURKEY
SN 1308-5727
EI 1308-5735
J9 J CLIN RES PEDIATR E
JI J. Clin Res. Pediatr. Endocrinol.
PD DEC
PY 2018
VL 10
IS 4
BP 364
EP 372
AR PMID 29789273
DI 10.4274/jcrpe.0055
PG 9
WC Endocrinology & Metabolism; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Pediatrics
GA HC2YE
UT WOS:000451667000010
PM 29789273
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Küçük, L
   Kaya, H
   Çömez, T
   Kaçar, S
   Kutlu, Y
   Zülfikar, H
AF Kucuk, Leyla
   Kaya, Hatice
   Comez, Tuba
   Kacar, Selma
   Kutlu, Yasemin
   Zulfikar, Haluk
TI Eating Behaviors and Related Factors in Psychiatric Patients
SO ARCHIVES OF PSYCHIATRIC NURSING
LA English
DT Article
DE Mental disorder; Nutrition; Eating attitude
ID NUTRITIONAL-STATUS; METABOLIC SYNDROME; RISK-FACTORS; ORAL-HEALTH;
   DISORDERS; PEOPLE; SCHIZOPHRENIA; PREVALENCE; MORTALITY; ANXIETY
AB The aim of this study was to determine the risk of eating disorders and associated risk factors in individuals with psychiatric disorders. Patients who were hospitalized in a psychiatry clinic of the university hospital between the dates of February 2014 and July 2014 constitute sample for the study. The study sample consisted of a total of 216 patients. Data were collected using a questionnaire form and the Eating Attitude Test.
   The mean age of the patients was 37 +/- 0.5, and 56.9% of the patients were female. Problems in eating behavior were observed in 11.6% of the patients, and a statistically significant relationship was found between the risk of eating disorders and diagnosis, gender, exercise and self-perception of weight.
   The risk of eating disorders was more frequently observed in patients diagnosed with depression, in female patients with a self-perceived weight problem and do not exercise.
C1 [Kucuk, Leyla; Kutlu, Yasemin] Istanbul Univ, Florence Nightingale Nursing Fac, Mental Hlth & Psychiat Nursing Dept, Sisli, Turkey.
   [Kaya, Hatice] Istanbul Univ, Florence Nightingale Nursing Fac, Fundamental Nursing Dept, Sisli, Turkey.
   [Comez, Tuba] Istanbul Univ, Hlth Sci Inst, Mental Hlth & Psychiat Nursing Dept, Cerrahpasa, Turkey.
   [Kacar, Selma] Istanbul Univ, Cerrahpasa Med Fac, Mental Hlth Serv, Kocamustafapasa Istanbul, Turkey.
   [Zulfikar, Haluk] Istanbul Univ, Fac Econ, Beyazit, Turkey.
C3 Istanbul University - Cerrahpasa; Istanbul University; Istanbul
   University; Istanbul University - Cerrahpasa; Istanbul University -
   Cerrahpasa; Istanbul University; Istanbul University - Cerrahpasa;
   Istanbul University; Istanbul University
RP Küçük, L (corresponding author), Istanbul Univ, Florence Nightingale Nursing Fac, Mental Hlth & Psychiat Nursing Dept, Sisli, Turkey.
EM leylak73@istanbul.edu.tr; haticeka@istanbul.edu.tr;
   tuba-comez@hotmail.com; selmasenlikci@gmail.com; ykutlu@gmail.com;
   zulfikar@istanbul.edu.tr
RI Küçük, Leyla/C-9631-2019; zulfikar, haluk/AAE-1834-2020; Çömez İkican,
   Tuba/AGV-6883-2022; Kutlu, Yasemin/Q-6107-2017; Kaya, Hatice/I-2179-2016
OI COMEZ IKICAN, TUBA/0000-0003-0929-8168; Kucuk, Leyla/0000-0003-0102-2968
FU Istanbul University [BAP:21797]
FX We would like to thank all patients. We would also like to thank
   Istanbul University Scientific Research Projects ID:BAP:21797.
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NR 60
TC 8
Z9 8
U1 0
U2 16
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0883-9417
EI 1532-8228
J9 ARCH PSYCHIAT NURS
JI Arch. Psychiatr. Nurs.
PD APR
PY 2018
VL 32
IS 2
BP 194
EP 199
DI 10.1016/j.apnu.2017.10.015
PG 6
WC Nursing; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Psychiatry
GA GB6ML
UT WOS:000429183200005
PM 29579512
DA 2025-06-11
ER

PT J
AU Rhim, E
   Han, K
   Yun, KI
AF Rhim, Eunmi
   Han, Kyungdo
   Yun, Kyoung-In
TI Association between temporomandibular disorders and obesity
SO JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY
LA English
DT Article
DE Cross-sectional studies; Population statistics; Temporomandibular joint
   disorder; Body mass index; Waist circumference
ID BODY-MASS-INDEX; PSYCHOLOGICAL STRESS; WAIST CIRCUMFERENCE; BITE FORCE;
   WEIGHT; WOMEN; ADOLESCENTS; PATTERNS; GENDER; HEALTH
AB Psychological stress can induce altered eating patterns, and studies have indicated that there is a correlation between temporomandibular disorder (TMD) and psychological stress. This study investigated the relationship between TMD and body mass index (BMI) in a large representative sample of the South Korean population using data from the Korea National Health and Nutrition Examination Survey (KNHANES). Men and women with TMD showed decreased prevalence of abdominal obesity. Women with TMD had lower age, lower BMI, lower metabolic syndromic waist circumference, lower prevalence of metabolic syndrome, and lower prevalence of diabetes compared with the group without TMD. However, males with TMD didn't show any statistically significant difference between BMI, and metabolic syndromic waist circumference compared with the group without TMD, although there were similar tendencies in the female subject groups. Overall, TMD was associated with decreased BMI and abdominal obesity in women. (C) 2016 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.
C1 [Rhim, Eunmi] Catholic Univ Korea, Yeouido St Marys Hosp, Dept Conservat Dent & Endodont, Seoul, South Korea.
   [Han, Kyungdo] Catholic Univ Korea, Coll Med, Dept Biostat, Seoul, South Korea.
   [Yun, Kyoung-In] Catholic Univ Korea, Yeouido St Marys Hosp, Dept Oral & Maxillofacial Surg, Seoul, South Korea.
C3 Catholic University of Korea; Catholic University of Korea; Catholic
   University of Korea
RP Yun, KI (corresponding author), Catholic Univ Korea, Yeouido St Marys Hosp, Dept Oral & Maxillofacial Surg, Seoul, South Korea.
EM yun_ki@catholic.ac.kr
RI Han, Kyungdo/JKH-7628-2023
FU Institute of Clinical Medicine Research in the Catholic University of
   Korea, Yeouido St. Mary's Hospital
FX This study was funded by research grant from Institute of Clinical
   Medicine Research in the Catholic University of Korea, Yeouido St.
   Mary's Hospital. The authors thank the Korea Centers of Disease Control
   and Prevention for providing the data. The authors declare no potential
   conflicts of interest with respect to the authorship and/or publication
   of this article.
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NR 35
TC 26
Z9 28
U1 0
U2 6
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 1010-5182
EI 1878-4119
J9 J CRANIO MAXILL SURG
JI J. Cranio-MaxilloFac. Surg.
PD AUG
PY 2016
VL 44
IS 8
BP 1003
EP 1007
DI 10.1016/j.jcms.2016.04.016
PG 5
WC Dentistry, Oral Surgery & Medicine; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dentistry, Oral Surgery & Medicine; Surgery
GA DT2PF
UT WOS:000381322200016
PM 27349686
DA 2025-06-11
ER

PT J
AU Rafiee, P
   Rasaei, N
   Amini, MR
   Rabiee, R
   Kalantar, Z
   Sheikhhossein, F
   Gholizadeh, M
   Hekmatdoost, A
AF Rafiee, Pegah
   Rasaei, Niloufar
   Amini, Mohammad Reza
   Rabiee, Reyhaneh
   Kalantar, Zahra
   Sheikhhossein, Fatemeh
   Gholizadeh, Mohammad
   Hekmatdoost, Azita
TI The effects of ursolic acid on cardiometabolic risk factors: a
   systematic review and meta-analysis
SO FUTURE CARDIOLOGY
LA English
DT Review
DE cardiometabolic risk factors; meta-analysis; ursolic acid
ID TYROSINE-PHOSPHATASE 1B; CARDIOVASCULAR RISK; METABOLIC SYNDROME; MUSCLE
   STRENGTH; DOUBLE-BLIND; INFLAMMATION; DIET; MASS
AB Aim: Ursolic acid (UA) has an important biological role in the fight against fat accumulation, insulin resistance, obesity and inflammation. Therefore, in the current review and meta-analysis work, we investigate the effects of UA (dosage range is 50.94 to 450 mg/day) on cardiometabolic risk factors. Materials & methods: After searching the studies up to February 2023, six articles were included in the study. Results: The pooled effect size showed that UA supplementation didn't significantly change body weight, body mass index, waist circumference, body fat percentage, lean body mass, systolic blood pressure, diastolic blood pressure, fasting blood glucose, insulin, triglycer ide and high-density lipoprotein compared with control groups. Conclusion: UA supplementation had no significant effect on the cardiometabolic risk factors in adults.
   Plain language summary: Cardiovascular disease (CVD) is a significant reason for morbidity and mortality. Ursolic acid (UA) has been shown to play important biological roles in the fight against fat accumulation, oxidative stress, insulin resistance via insulin-like growth factor 1, cancer, muscle atrophy, obesity and inflammation responsible for CVD. A systematic review and meta-analysis were conducted up to February 2023; six articles were included in the study and eleven cardiometabolic risk factors were identified. The pooled effect size showed that UA supplementation (dosage range is 50.94 to 450 mg/day) didn't significantly change body weight, body mass index, waist circumference, body fat percentage, lean body mass, systolic blood pressure, diastolic blood pressure, fasting blood glucose, insulin, triglyceride, and high-density lipoprotein compared with control groups.
C1 [Rafiee, Pegah; Amini, Mohammad Reza] Shahid Beheshti Univ Med Sci, Natl Nutr & Food Technol Res Inst, Fac Nutr & Food Technol, Dept Clin Nutr & Dietet,Student Res Comm, Tehran 1981619573, Iran.
   [Rasaei, Niloufar] Tehran Univ Med Sci IC TUMS, Sch Nutr Sci & Dietet, Dept Community Nutr, Tehran 141556117, Iran.
   [Rasaei, Niloufar] Universal Sci Educ & Res Network USERN, Network Interdisciplinar Neonates & Infants NINI, Tehran 141556117, Iran.
   [Amini, Mohammad Reza] Isfahan Univ Med Sci, Sch Nutr & Food Sci, Nutr & Food Secur Res Ctr, Esfahan 1981619573, Iran.
   [Amini, Mohammad Reza] Isfahan Univ Med Sci, Sch Nutr & Food Sci, Dept Community Nutr, Esfahan 1981619573, Iran.
   [Rabiee, Reyhaneh] Shahid Sadoughi Univ Med Sci, Student Res Comm, Sch Publ Hlth, Dept Nutr, Yazd 8915173160, Iran.
   [Kalantar, Zahra; Sheikhhossein, Fatemeh] Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Clin Nutr, Tehran 141556117, Iran.
   [Gholizadeh, Mohammad; Hekmatdoost, Azita] Shahid Beheshti Univ Med Sci, Natl Nutr & Food Technol Res Inst, Fac Nutr Sci & Food Technol, Dept Clin Nutr & Dietet, Tehran 1981619573, Iran.
C3 Shahid Beheshti University Medical Sciences; Universal Scientific
   Education & Research Network (USERN); Isfahan University of Medical
   Sciences; Isfahan University of Medical Sciences; Shahid Sadoughi
   University of Medical Sciences; Tehran University of Medical Sciences;
   Shahid Beheshti University Medical Sciences
RP Hekmatdoost, A (corresponding author), Shahid Beheshti Univ Med Sci, Natl Nutr & Food Technol Res Inst, Fac Nutr Sci & Food Technol, Dept Clin Nutr & Dietet, Tehran 1981619573, Iran.
EM A_hekmat2000@yahoo.com
RI Amini, Mohammad/ABD-9638-2020; rafiee, pegah/JOK-5745-2023; Gholizadeh,
   Mohammad/KGL-1509-2024; Hekmatdoost, Azita/AGM-6497-2022
OI Kalantar, Zahra/0000-0001-6285-4835; Gholizadeh,
   Mohammad/0000-0001-9710-5068; Hekmatdoost, Azita/0000-0002-1944-0052;
   Amini, Mohammad Reza/0000-0003-0640-2142; Rabiee,
   Reyhaneh/0009-0007-9292-8306
FU Student Research Committee, Shahid Beheshti University of Medical
   Sciences, Tehran, Iran [1401/59204]; Shahid Beheshti University of
   Medical Sciences
FX This study is related to project NO. 1401/59204 From Student Research
   Committee, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
   We also appreciate the 'Student Research Committee' and 'Research &
   Technology Chancellor' at Shahid Beheshti University of Medical Sciences
   for their financial support of this study. The authors have no other
   relevant affiliations or financial involvement with any organization or
   entity with a financial interest in or financial conflict with the
   subject matter or materials discussed in the manuscript apart from those
   disclosed.
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NR 51
TC 1
Z9 1
U1 1
U2 1
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1479-6678
EI 1744-8298
J9 FUTUR CARDIOL
JI Futur. Cardiol.
PD FEB 17
PY 2024
VL 20
IS 3
BP 151
EP 161
AR 2349476
DI 10.1080/14796678.2024.2349476
EA MAY 2024
PG 11
WC Cardiac & Cardiovascular Systems
WE Emerging Sources Citation Index (ESCI)
SC Cardiovascular System & Cardiology
GA WN9X6
UT WOS:001235362900001
PM 38923885
DA 2025-06-11
ER

PT J
AU Costa, JO
   Vasquez, CMP
   Santana, GD
   Silva, ND
   Braz, JD
   de Jesus, AMR
   da Silva, DG
   Cunha, LCS
   Barbosa, KBF
AF Costa, Jamille Oliveira
   Passos Vasquez, Cecilia M.
   Santana, Gleiciane de Jesus
   Silva, Natanael de Jesus
   Braz, Juciene de Matos
   Ribeiro de Jesus, Amelia M.
   da Silva, Danielle Goes
   Seraphim Cunha, Luana Celina
   Ferreira Barbosa, Kiriaque Barra
TI Plasma Total Antioxidant Capacity and Cardiometabolic Risk in Non-Obese
   and Clinically Healthy Young Adults
SO ARQUIVOS BRASILEIROS DE CARDIOLOGIA
LA English
DT Article
DE Cardiovascular Diseases; Risk Factors; Metabolic Syndrome; Oxidative
   Stress; Antioxidants; Young Adult
ID DENSITY-LIPOPROTEIN; CHOLESTEROL RATIO; PREDICTORS; TRIGLYCERIDES;
   CARBOHYDRATE; RESISTANCE; ENERGY
AB Background: The oxidative biomarkers play an important role in the genesis of cardiometabolic risk-related processes.
   Objective: To investigate the total antioxidant capacity of plasma and its association with cardiometabolic risk in non-obese and clinically healthy young adults.
   Methods: University students of the state of Sergipe, Brazil, aged between 18 and 25 years, were recruited for this study from May of 2013 and October of 2014. Anthropometric, clinical and biochemical parameters were measured and analyzed using protocols which were previously standardized and described in the literature. The measurement of plasma total antioxidant capacity was based on the ability that all the antioxidants present in the sample (plasma) have to inhibit the oxidation of the oxidizable substrate ABTS (2,2'-Azino-di-[3-ethylbenzthiazoline sulphonate]) to ABTS center dot+ by metmyoglobin.
   Results: Approximately 25% of the sample presented more than one component of cardiometabolic risk. Low HDL-cholesterol was the most prevalent component. Compared to absence of components, the subjects with at least one component presented greater body weight and waist circumference, higher levels of diastolic blood pressure and fasting glucose, greater total cholesterol/HDL-c ratio, and lower levels of HDL-c (p < 0.05). Fasting glycemia was the only parameter which was associated with total antioxidant capacity (R-2 = 0.10; beta = 0.17; p = 0.001).
   Conclusions: The plasma total antioxidant capacity was not able to predict the cardiometabolic risk components due possibly to the establishment of compensatory mechanisms that become activated in physiological conditions.
C1 [Costa, Jamille Oliveira; Passos Vasquez, Cecilia M.; Santana, Gleiciane de Jesus; Silva, Natanael de Jesus; Braz, Juciene de Matos; Ribeiro de Jesus, Amelia M.; da Silva, Danielle Goes; Seraphim Cunha, Luana Celina; Ferreira Barbosa, Kiriaque Barra] UFS, Aracaju, SE, Brazil.
RP Barbosa, KBF (corresponding author), Av Marechal Rondon S-N, BR-49100000 Sao Cristovao, SE, Brazil.
EM kiribarra@yahoo.com.br
RI Barbosa, Kiriaque/E-4269-2014; de Jesus Silva, Natanael/AAS-2223-2021
FU Fundacao de Apoio a Pesquisa e a Inovacao Tecnologica do Estado de
   Sergipe
FX This study was funded by Fundacao de Apoio a Pesquisa e a Inovacao
   Tecnologica do Estado de Sergipe.
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NR 40
TC 8
Z9 8
U1 0
U2 8
PU ARQUIVOS BRASILEIROS CARDIOLOGIA
PI RIO DE JANEIRO
PA AVENIDA MARECHAL CAMARA 160-330 CENTRO, RIO DE JANEIRO, RJ 20 020-907,
   BRAZIL
SN 0066-782X
EI 1678-4170
J9 ARQ BRAS CARDIOL
JI Arq. Bras. Cardiol.
PD AUG
PY 2017
VL 109
IS 2
BP 140
EP 146
DI 10.5935/abc.20170095
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA FG9QY
UT WOS:000410775300008
PM 28700017
OA Green Submitted, gold, Green Published
DA 2025-06-11
ER

PT J
AU Marco, EM
   García-Gutíerrez, MS
   Bermúdez-Silva, FJ
   Moreira, FA
   Guimaraes, F
   Manzanares, J
   Viveros, MP
AF Marco, Eva M.
   Garcia-Gutierrez, Maria S.
   Bermudez-Silva, Francisco-Javier
   Moreira, Fabricio A.
   Guimaraes, Francisco
   Manzanares, Jorge
   Viveros, Maria-Paz
TI Endocannabinoid system and psychiatry: in search of a neurobiological
   basis for detrimental and potential therapeutic effects
SO FRONTIERS IN BEHAVIORAL NEUROSCIENCE
LA English
DT Article
DE cannabinoid receptor; cannabidiol; cognition; emotion; anxiety;
   depression; schizophrenia; eating disorders
ID CANNABINOID CB1 RECEPTOR; DORSOLATERAL PERIAQUEDUCTAL GRAY; EARLY
   MATERNAL-DEPRIVATION; CARDIOMETABOLIC RISK-FACTORS; ANTERIOR CINGULATE
   CORTEX; BINGE-EATING DISORDER; ANXIETY-LIKE BEHAVIOR; ANOREXIA-NERVOSA;
   SOCIAL-ISOLATION; RAT-BRAIN
AB Public concern on mental health has noticeably increased given the high prevalence of neuropsychiatric disorders. Cognition and emotionality are the most affected functions in neuropsychiatric disorders, i.e., anxiety disorders, depression, and schizophrenia. In this review, most relevant literature on the role of the endocannabinoid (eCB) system in neuropsychiatric disorders will be presented. Evidence from clinical and animal studies is provided for the participation of CB1 and CB2 receptors (CB1R and CB2R) in the above mentioned neuropsychiatric disorders. CBRs are crucial in some of the emotional and cognitive impairments reported, although more research is required to understand the specific role of the eCB system in neuropsychiatric disorders. Cannabidiol (CBD), the main non-psychotropic component of the Cannabis sativa plant, has shown therapeutic potential in several neuropsychiatric disorders. Although further studies are needed, recent studies indicate that CBD therapeutic effects may partially depend on facilitation of eCB-mediated neurotransmission. Last but not least, this review includes recent findings on the role of the eCB system in eating disorders. A deregulation of the eCB system has been proposed to be in the bases of several neuropsychiatric disorders, including eating disorders. Cannabis consumption has been related to the appearance of psychotic symptoms and schizophrenia. In contrast, the pharmacological manipulation of this eCB system has been proposed as a potential strategy for the treatment of anxiety disorders, depression, and anorexia nervosa. In conclusion, the eCB system plays a critical role in psychiatry; however, detrimental consequences of manipulating this endogenous system cannot be underestimated over the potential and promising perspectives of its therapeutic manipulation.
C1 [Marco, Eva M.; Viveros, Maria-Paz] Univ Complutense Madrid, Fac Ciencias Biol, Dept Fisiol Fisiol Anim 2, E-28040 Madrid, Spain.
   [Marco, Eva M.; Viveros, Maria-Paz] Hosp Clin San Carlos, Inst Invest Sanitaria, Madrid, Spain.
   [Garcia-Gutierrez, Maria S.; Manzanares, Jorge] Univ Miguel Hernandez, Inst Neurociencias Alicante, CSIC, Alacant, Spain.
   [Bermudez-Silva, Francisco-Javier] Hosp Carlos Haya de Malaga, Fdn IMABIS, Lab Med Regenerat, Malaga, Spain.
   [Bermudez-Silva, Francisco-Javier] Univ Bordeaux 2, INSERM, Neuroctr Magendie, F-33076 Bordeaux, France.
   [Moreira, Fabricio A.] Univ Fed Minas Gerais, Inst Biol Sci, Dept Pharmacol, Belo Horizonte, MG, Brazil.
   [Guimaraes, Francisco] Univ Sao Paulo, Sch Med Ribeirao Preto, Dept Pharmacol, BR-14049 Ribeirao Preto, SP, Brazil.
C3 Complutense University of Madrid; Hospital Clinico San Carlos; Consejo
   Superior de Investigaciones Cientificas (CSIC); Universidad Miguel
   Hernandez de Elche; CSIC-UMH - Instituto de Neurociencias de Alicante
   (IN); FIMABIS; Institut National de la Sante et de la Recherche Medicale
   (Inserm); Universite de Bordeaux; Universidade Federal de Minas Gerais;
   Universidade de Sao Paulo
RP Marco, EM (corresponding author), Univ Complutense Madrid, Fac Ciencias Biol, Dept Fisiol Fisiol Anim 2, Ciudad Univ,C Jose Antonio Novais 2, E-28040 Madrid, Spain.
EM emmarco@bio.ucm.es; pazviver@bio.ucm.es
RI Guimaraes, Francisco/C-1059-2012; Gutiérrez, Maria/AAY-6406-2021; Marco,
   Eva/ABH-3257-2020; Marco, Eva M./K-8224-2015; Viveros,
   Maria-Paz/S-6855-2016; Bermudez-Silva, Francisco-Javier/Q-6920-2016
OI Marco, Eva M./0000-0002-2457-475X; Moreira,
   Fabricio/0000-0002-0824-7302; Manzanares, Jorge/0000-0003-3830-7107;
   Manzanares, Jorge/0000-0002-4681-1533; Garcia-Gutierrez, Maria
   Salud/0000-0001-6106-6247; Viveros, Maria-Paz/0000-0002-4119-4636;
   Bermudez-Silva, Francisco-Javier/0000-0003-3133-9691
FU National System of Health (Instituto de Salud Carlos III) [CP07/00283];
   Instituto de Salud Carlos III [BA09/90066]; Instituto de Salud Carlos
   III, Redes tematicas de Investigacion Cooperativa en salud (ISCIII y
   FEDER) [RD06/0001/1013, RD06/0001/1004]; Ministerio de Ciencia e
   Innovacion [BFU2009-10109, 951579]; Plan Nacional sobre Drogas
   [SAS/1250/2009]; Ministerio de Sanidad [10/02308]
FX Instituto de Salud Carlos III, Redes tematicas de Investigacion
   Cooperativa en salud (ISCIII y FEDER): RD06/0001/1013 and
   RD06/0001/1004; Ministerio de Ciencia e Innovacion: BFU2009-10109,
   GRUPOS UCM-BSCH (951579); Plan Nacional sobre Drogas SAS/1250/2009.
   Ministerio de Sanidad (10/02308). Francisco-Javier Bermudez-Silva is
   recipient of a research contract from the National System of Health
   (Instituto de Salud Carlos III; CP07/00283) and of a BAE from Instituto
   de Salud Carlos III (BA09/90066).
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NR 291
TC 102
Z9 111
U1 1
U2 33
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1662-5153
J9 FRONT BEHAV NEUROSCI
JI Front. Behav. Neurosci.
PD OCT 5
PY 2011
VL 5
AR 63
DI 10.3389/fnbeh.2011.00063
PG 23
WC Behavioral Sciences; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Behavioral Sciences; Neurosciences & Neurology
GA 844CU
UT WOS:000296726100001
PM 22007164
OA Green Published, Green Accepted, gold
DA 2025-06-11
ER

PT J
AU Tu, CY
   Chiu, MR
   Wang, YW
   Hsu, CY
   Chen, YY
   Chang, SS
AF Tu, Chao-Ying
   Chiu, Meng-Rou
   Wang, Yi-Wen
   Hsu, Chia-Yueh
   Chen, Ying-Yeh
   Chang, Shu-Sen
TI Association of Body Mass Index and Cardiometabolic Factors With Elderly
   Suicide: A Cohort Study of 101,518 Older Taiwanese
SO AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
LA English
DT Article
DE Body mass index; cardiometabolic risk factors; older people; suicide
ID METABOLIC SYNDROME; RISK-FACTORS; CARDIOVASCULAR-DISEASE; COMPLETED
   SUICIDE; SOCIAL-ISOLATION; UNITED-STATES; HEART-RATE; MORTALITY; HEALTH;
   DEPRESSION
AB Background: Older people have the highest suicide rate across age groups in most countries. The prevalence of cardiometabolic risk factors also increases with age. We investigated the association between body mass index (BMI), cardiometabolic risk factors, and suicide in a large cohort of older people in Taiwan.Methods: We conducted a cohort study using data from an elderly health examination program in Taipei City, Taiwan (2005-2010), linked to the national cause-of-death data files. We used competing risk Cox regression models to investigate the associations of BMI (kg/m(2)) and cardiometabolic factors with suicide after adjusting for sex, age, socioeconomic variables, chronic diseases, psychological distress, and cognitive function.Results: Among 101,518 individuals aged >= 65 years, 92 died by suicide during an average follow-up of 3.9 years. Underweight (BMI<18.5) was associated with increased suicide risk (adjusted hazard ratio [aHR]=2.33, 95% confidence interval [CI] 1.20-4.52) (reference: normal weight). Low diastolic blood pressure was associated with increased suicide risk - aHR was 0.51 (95% CI 0.29-0.91) and 0.55 (95% CI 0.31-0.99) for the third and fourth quartiles of diastolic blood pressure (reference: the lowest quartile), respectively. Older people with a higher waist circumference (aHR per 1-standard-deviation increase=0.60 [95% CI 0.37-0.98]) and a higher number of metabolic syndrome criteria (aHR per 1-criterion increase=0.65 [95% 0.46-0.92]) had lower suicide risk. Systolic blood pressure, pulse rate, fasting blood glucose, and lipid profiles were not associated with suicide risk.Conclusions: Underweight, low diastolic blood pressure, and low waist circumference may be markers of increased suicide risk in older people.
C1 [Tu, Chao-Ying] Natl Taiwan Univ Hosp, Dept Psychiat, Yunlin Branch, Touliu, Yunlin County, Taiwan.
   [Tu, Chao-Ying] Natl Taiwan Univ, Coll Med, Dept Psychiat, Taipei City, Taiwan.
   [Tu, Chao-Ying] Natl Taiwan Univ, Inst Hlth Policy & Management, Coll Publ Hlth, Taipei City, Taiwan.
   [Chiu, Meng-Rou] Yonghe Cardinal Tien Hosp, Dept Occupat Therapy, New Taipei City, Taiwan.
   [Chiu, Meng-Rou; Chang, Shu-Sen] Natl Taiwan Univ, Inst Hlth Behav & Community Sci, Coll Publ Hlth, Room 623, 17,Xu Zhou Rd, Taipei City 10055, Taiwan.
   [Wang, Yi-Wen; Hsu, Chia-Yueh] Taipei Med Univ, Coll Med, Sch Med, Dept Psychiat, Taipei City, Taiwan.
   [Hsu, Chia-Yueh] Taipei Med Univ, Wan Fang Hosp, Dept Psychiat, Taipei City, Taiwan.
   [Hsu, Chia-Yueh; Chang, Shu-Sen] Taipei Med Univ, Wan Fang Hosp, Psychiat Res Ctr, Taipei City, Taiwan.
   [Chen, Ying-Yeh] Taipei City Hosp, Taipei City Psychiat Ctr, Taipei City, Taiwan.
   [Chen, Ying-Yeh] Natl Yang Ming Chiao Tung Univ, Inst Publ Hlth, Taipei City, Taiwan.
   [Chen, Ying-Yeh] Natl Yang Ming Chiao Tung Univ, Dept Publ Hlth, Taipei City, Taiwan.
C3 National Taiwan University; National Taiwan University Hospital;
   National Taiwan University; National Taiwan University; National Taiwan
   University; Taipei Municipal WanFang Hospital; Taipei Municipal WanFang
   Hospital; Taipei City Hospital
RP Chang, SS (corresponding author), Natl Taiwan Univ, Inst Hlth Behav & Community Sci, Coll Publ Hlth, Room 623, 17,Xu Zhou Rd, Taipei City 10055, Taiwan.
EM shusenchang@ntu.edu.tw
RI Chen, Ying-Yeh/AAY-1478-2021; Chang, Shu-Sen/AAH-6733-2021; cheng,
   chien-yu/M-1108-2019
FU Taiwan National Council of Science and Technol-ogy [NSTC
   111-2314-B-002-290]; National Taiwan University Hospital Yunlin Branch
   [112-F003]
FX The study was not funded. Chia-Yueh Hsu was supported by grants from the
   Taiwan National Council of Science and Technology (grant MOST
   110-2628-B-038-016- and NSTC 111-2628-B-038-026) and Wan Fang Hospital
   (grant 111-wf-swf-04 and 112-wf-swf-02) . Shu-Sen Chang was supported by
   a grant from the Taiwan National Council of Science and Technology
   (grant MOST 109-2314-B-002-144-MY3) . Chao-Ying Tu was supported by
   grantsfrom the Taiwan National Council of Science and Technology (grant
   number NSTC 111-2314-B-002-290) and National Taiwan University Hospital
   Yunlin Branch (grant number 112-F003) .r from the Taiwan National
   Council of Science and Technol-ogy (grant number NSTC
   111-2314-B-002-290) and National Taiwan University Hospital Yunlin
   Branch (grant number 112-F003) .
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NR 48
TC 3
Z9 3
U1 1
U2 5
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1064-7481
EI 1545-7214
J9 AM J GERIAT PSYCHIAT
JI Am. J. Geriatr. Psychiatr.
PD NOV
PY 2023
VL 31
IS 11
BP 965
EP 977
DI 10.1016/j.jagp.2023.05.002
EA OCT 2023
PG 13
WC Geriatrics & Gerontology; Gerontology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Psychiatry
GA Y1BK8
UT WOS:001102688500001
PM 37258341
DA 2025-06-11
ER

PT J
AU Laddu, DR
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   Kaar, J
   Khadanga, S
   Alman, R
   Arena, R
AF Laddu, Deepika R.
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   Kaar, Jill
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   Alman, Rocio
   Arena, Ross
TI The impact of the COVID-19 pandemic on cardiovascular health behaviors
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SO PROGRESS IN CARDIOVASCULAR DISEASES
LA English
DT Review
DE COVID-19; Cardiovascular disease; Health behaviors
ID UNITED-STATES; MENTAL-HEALTH; ADULTS; DEPRESSION; LOCKDOWN; ANXIETY
AB In March 2020, the Coronavirus disease 2019 (COVID-19) outbreak was officially declared a global pandemic, leading to closure of public facilities, enforced social distancing and stay-at-home mandates to limit exposures and reduce transmission rates. While the severity of this "lockdown" period varied by country, the disruptions of the pandemic on multiple facets of life (e.g., daily activities, education, the workplace) as well as the social, eco-nomic, and healthcare systems impacts were unprecedented. These disruptions and impacts are having a pro-found negative effect on multiple facets of behavioral health and psychosocial wellbeing that are inextricably linked to cardiometabolic health and associated with adverse outcomes of COVID-19. For example, adoption of various cardiometabolic risk behavior behaviors observed during the pandemic contributed to irretractable trends in weight gain and poor mental health, raising concerns on the possible long-term consequences of the pandemic on cardiometabolic disease risk, and vulnerabilities to future viral pandemics. The purpose of this re-view is to summarize the direct and indirect effects of the pandemic on cardiometabolic health risk behaviors, particularly related to poor diet quality, physical inactivity and sedentary behaviors, smoking, sleep patterns and mental health. Additional insights into how the pandemic has amplified cardiovascular risk behaviors, par-ticularly in our most vulnerable populations, and the potential implications for the future if these modifiable risk behaviors do not become better controlled, are described.(c) 2022 Elsevier Inc. All rights reserved.
C1 [Laddu, Deepika R.; Arena, Ross] Univ Illinois, Coll Appl Sci, Dept Phys Therapy, Chicago, IL USA.
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C3 University of Illinois System; University of Illinois Chicago;
   University of Illinois Chicago Hospital; University of Colorado System;
   University of Colorado Anschutz Medical Campus; University of Vermont;
   University of Illinois System; University of Illinois Chicago;
   University of Illinois Chicago Hospital
RP Laddu, DR (corresponding author), Univ Illinois, Coll Appl Hlth Sci, Dept Phys Therapy, 1919 W Taylor St,M-C 898, Chicago, IL 60612 USA.
EM dladdu@uic.edu
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NR 92
TC 21
Z9 21
U1 1
U2 9
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0033-0620
EI 1873-1740
J9 PROG CARDIOVASC DIS
JI Prog. Cardiovasc. Dis.
PD JAN-FEB
PY 2023
VL 76
BP 38
EP 43
DI 10.1016/j.pcad.2022.11.017
EA MAR 2023
PG 6
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA A6OX1
UT WOS:000956306500001
PM 36481209
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Tang, AL
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AF Tang, Alva
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   Slopen, Natalie
TI Parent-child separation and cardiometabolic outcomes and risk factors in
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SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Review
DE Cardiovascular disease; Metabolic disease; Metabolic syndrome;
   Parent-child separation; War evacuation; Foster care; Temporary care;
   Parental incarceration; Childhood
ID EARLY-LIFE STRESS; HEALTH OUTCOMES; PSYCHOLOGICAL STRESS; HEART-DISEASE;
   PUBLIC CARE; MIDDLE-AGE; ADOLESCENTS; EXPERIENCES; ASSOCIATION; YOUTH
AB Background: Parent-child separation has been associated with negative mental health across childhood and adulthood, yet little is known about the long-term impacts for cardiovascular health. This systematic review synthesized and evaluated the quality of the literature examining the association between exposures to parent-child separation and cardiometabolic outcomes in adulthood.
   Methods: Following a registered protocol, online databases (Pubmed, PsycInfo, and Web of Science) were searched for relevant studies. Studies were included if they (a) defined the exposure before age 18 as institutionalization, foster care placement, parental incarceration, separation due to parents migrating for economic reasons, or asylum and war; and (b) quantified the association between parent-child separation and cardiometabolic events and diagnoses (e.g., coronary heart disease, diabetes) and risk factors (e.g., body mass index, fat distribution, serum-based metabolic markers, inflammatory markers in adulthood (>= age 18). Studies lacking an unexposed comparison group were excluded. The risk for bias in each study was assessed with a modified Newcastle-Ottawa Scale.
   Results: Of the 1938 studies identified, 13 met our inclusion criteria. Two of the four studies examining associations between parent-child separation and cardiometabolic events and diagnoses found positive associations with coronary heart disease and diabetes. Amongst the 13 studies examining associations with any type of adult cardiometabolic risk factors, eight studies reported at least one positive association. Sub-analyses considering separate reasons for parent-child separation provided clearer insights: War evacuation was associated with hypertension and high blood pressure across four studies from the same cohort; out-of home care experiences largely evidenced null results across five different studies, and two studies on parental incarceration suggested positive associations with elevated inflammation, BMI and blood pressure.
   Conclusions: The connections between parent-child separation and adult cardiometabolic outcomes and risk factors are currently inconsistent. The results may depend on the reason for separation, age of assessment, analytic differences and other psychosocial variables that are often unmeasured in this literature.
C1 [Tang, Alva] Univ Texas Dallas, Dept Psychol, Dallas, TX USA.
   [Ertel, Karen A.; Keen, Ryan; Beyer, Logan; Pintro, Kedie; Okuzono, Sakurako S.; Yazawa, Aki; Slopen, Natalie] Harvard TH Chan Sch Publ Hlth, Dept Social & Behav Sci, Boston, MA USA.
   [Ertel, Karen A.] Univ Massachusetts Amherst, Dept Biostat & Epidemiol, Amherst, MA USA.
   [Beyer, Logan] Harvard Univ, Harvard Med Sch, Cambridge, MA USA.
   [Eckert, Natalie] Tufts Univ, Dept Community Hlth, Medford, MA USA.
   [Mita, Carol] Harvard Med Sch, Countway Lib Med, Boston, MA USA.
   [Yazawa, Aki] Natl Ctr Global Hlth & Med, Ctr Clin Sci, Dept Epidemiol & Prevent, Tokyo, Japan.
   [Slopen, Natalie] Harvard Univ, Ctr Developing Child, Cambridge, MA USA.
   [Tang, Alva] Univ Texas Dallas, Dept Psychol, 800 Campbell Rd, Richardson, TX 75080 USA.
C3 University of Texas System; University of Texas Dallas; Harvard
   University; Harvard T.H. Chan School of Public Health; University of
   Massachusetts System; University of Massachusetts Amherst; Harvard
   University; Tufts University; Harvard University; Harvard Medical
   School; Japan Institute for Health Security (JIHS); National Center for
   Global Health & Medicine - Japan; Harvard University; University of
   Texas System; University of Texas Dallas
RP Tang, AL (corresponding author), Univ Texas Dallas, Dept Psychol, 800 Campbell Rd, Richardson, TX 75080 USA.
EM alvatang@utdallas.edu
RI Shiba, Sakurako/AAT-6687-2021
OI Keen, Ryan/0009-0001-3480-5603
FU National Institute on Aging (NIA) [R24AG065174]; National Institutes of
   Health [1R01HL151848-01]; Japan Society for the Promotion of Science
   Research Fellowship for Young Scientists [JP21J01171]
FX This project was supported by a seed grant from the Reversibility
   Network, a National Institute on Aging (NIA) -funded network of
   re-searchers whose mission is to advance research around remediating the
   effects of early life adversities (ELA) in mid and later life (Grant:
   R24AG065174) . In addition, Drs. Tang and Slopen were supported by the
   National Institutes of Health Grant (1R01HL151848-01) . Dr. Yazawa was
   financially supported by Japan Society for the Promotion of Science
   Research Fellowship for Young Scientists (JP21J01171) .
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NR 52
TC 3
Z9 3
U1 2
U2 12
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
EI 1873-3360
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD JUN
PY 2023
VL 152
AR 106084
DI 10.1016/j.psyneuen.2023.106084
EA MAR 2023
PG 18
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA D4MY2
UT WOS:000968500700001
PM 36996574
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Robinson, E
   Daly, M
   Putra, IGNE
AF Robinson, Eric
   Daly, Michael
   Putra, I. Gusti Ngurah Edi
TI The psychological burden associated with metabolic syndrome: Evidence
   from UK and US older adults
SO OBESITY SCIENCE & PRACTICE
LA English
DT Article
DE metabolic syndrome; non-communicable diseases (NCDs); psychological
   well-being
ID COHORT PROFILE; RISK; METAANALYSIS; DEPRESSION; HEALTH; ANXIETY; OBESE
AB IntroductionWe examined the psychological burden associated with metabolic syndrome (MetSyn).MethodsWe used comparable longitudinal data of older adults (>= 50 years) from the UK (English Longitudinal Study of Aging) and the US (Health and Retirement Study). We defined MetSyn based on biomarker assessments (e.g., blood pressure, impaired glycemic control). Using regression models, we tested a range of individual psychological outcomes (e.g., depressive symptoms) associated with MetSyn. We also examined whether these psychological outcomes may explain or moderate the link between MetSyn and non-communicable diseases (NCDs).FindingsMetSyn was associated cross-sectionally with a range of psychological outcomes, including depression, anxiety, loneliness, hopelessness, cynical hostility, social strain, negative affect and decreased positive affect, social support and purpose in life. There was no convincing evidence that psychological factors interacted with or explained (mediated) the relationship between MetSyn and increased risk of developing NCD over 10-year follow-ups.ConclusionsMetSyn and the psychological burden outcomes examined may have independent effects on NCD risk.
C1 [Robinson, Eric; Putra, I. Gusti Ngurah Edi] Univ Liverpool, Inst Populat Hlth, Dept Psychol, Eleanor Rathbone Bldg,Bedford St South, Liverpool L69 7ZA, England.
   [Daly, Michael] Maynooth Univ, Dept Psychol, Maynooth, Ireland.
C3 University of Liverpool; Maynooth University
RP Putra, IGNE (corresponding author), Univ Liverpool, Inst Populat Hlth, Dept Psychol, Eleanor Rathbone Bldg,Bedford St South, Liverpool L69 7ZA, England.
EM i.gusti.ngurah.edi.putra@liverpool.ac.uk
RI Putra, I Gusti Ngurah Edi/AAG-2836-2020
OI Putra, I Gusti Ngurah Edi/0000-0002-1014-6949; Robinson,
   Eric/0000-0003-3586-5533
FU Economic and Social Research Council [ES/V017594/1]
FX Economic and Social Research Council, Grant/Award Number: ES/V017594/1
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NR 21
TC 1
Z9 1
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2055-2238
J9 OBES SCI PRACT
JI OBES. SCI. PRACT.
PD AUG
PY 2024
VL 10
IS 4
AR e780
DI 10.1002/osp4.780
PG 9
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA XQ7Y3
UT WOS:001263222600001
PM 38974477
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Reddy, BR
   Maitra, S
   Jhelum, P
   Kumar, KP
   Bagul, PK
   Kaur, G
   Banerjee, SK
   Kumar, A
   Chakravarty, S
AF Reddy, B. Raghunath
   Maitra, Swati
   Jhelum, Priya
   Kumar, K. Praveen
   Bagul, Pankaj K.
   Kaur, Gagandeep
   Banerjee, Sanjay K.
   Kumar, Arvind
   Chakravarty, Sumana
TI Sirtuin 1 and 7 mediate resveratrol-induced recovery from hyper-anxiety
   in high-fructose-fed prediabetic rats
SO JOURNAL OF BIOSCIENCES
LA English
DT Article
DE Epigenetic; fructose; metformin; mood disorders; sirtuins; type 2
   diabetes
ID IMPROVES INSULIN SENSITIVITY; OXIDATIVE STRESS; EPIGENETIC MECHANISMS;
   METABOLIC SYNDROME; METFORMIN; RESISTANCE; BRAIN; PROTECTS; DISEASES;
   ASSAY
AB Hyperglycaemia in diabetes is either caused by reduced availability of insulin (type 1 diabetes, T1D) or insulin resistance to the cells (type 2 diabetes, T2D). In recent years, the prevalence of T2D has increased to an alarming proportion, encompassing 95% of the total diabetic burden, probably due to economy-driven changes in lifestyle. Recent epidemiological studies show comorbid depression, anxiety and related mental illness. To explore the molecular mechanisms underlying this comorbid conditions, we used Sprague-Dawley rats on high-fructose diet for 8 weeks to induce prediabetic condition. Rats with this metabolic syndrome also showed hyper-anxiety when they were subjected to anxiety-related behavioural assays. Rats were administered with resveratrol, an activator of sirtuins, and metformin, a standard antidiabetic drug, simultaneously with fructose. We observed that resveratrol was more effective in protecting from both the metabolic (prediabetic) and affective (anxiety) disorders than metformin. Molecular studies showed that recovery was associated with the upregulation of few nuclear sirtuins that act epigenetically - Sirt 1 and 7, which were significantly attenuated in the striatum of prediabetic rats. In conclusion, our study showed that hyper-anxiety associated with prediabetic condition is ameliorated by resveratrol through modulation of sirtuins, which is more or less similar to metformin.
C1 [Reddy, B. Raghunath; Maitra, Swati; Jhelum, Priya; Kumar, K. Praveen] Indian Inst Chem Technol IICT, Chem Biol, Hyderabad 500007, Andhra Pradesh, India.
   [Bagul, Pankaj K.; Kaur, Gagandeep; Banerjee, Sanjay K.; Chakravarty, Sumana] Indian Inst Chem Technol IICT, Med Chem & Pharmacol, Hyderabad 500007, Andhra Pradesh, India.
   [Kumar, Arvind] Ctr Cellular & Mol Biol CCMB, Uppal Rd, Hyderabad 500007, Andhra Pradesh, India.
   [Bagul, Pankaj K.; Banerjee, Sanjay K.] Translat Hlth Sci & Technol Inst THSTI, Drug Discovery Res Ctr DDRC, Faridabad 121001, Haryana, India.
C3 Council of Scientific & Industrial Research (CSIR) - India; CSIR -
   Indian Institute of Chemical Technology (IICT); Council of Scientific &
   Industrial Research (CSIR) - India; CSIR - Indian Institute of Chemical
   Technology (IICT); Council of Scientific & Industrial Research (CSIR) -
   India; CSIR - Centre for Cellular & Molecular Biology (CCMB); Department
   of Biotechnology (DBT) India; Translational Health Science & Technology
   Institute (THSTI)
RP Chakravarty, S (corresponding author), Indian Inst Chem Technol IICT, Med Chem & Pharmacol, Hyderabad 500007, Andhra Pradesh, India.
EM sumanachak@iict.res.in
RI Chakravarty, Sumana/AAW-2823-2021; Dr. Pankaj K. Bagul, M.S/I-3867-2012;
   Kumar, Arvind/B-6094-2009; JHELUM, PRIYA/ACY-0028-2022
OI Kumar, Arvind/0000-0003-2879-3826; JHELUM, PRIYA/0000-0003-0779-2816;
   Banerjee, Sanjay/0000-0002-0008-0480; Banerjee, Sanjay
   k/0000-0002-0044-0984
FU Ramalingaswami Re-entry Individual Fellowships; Department of
   Biotechnology, India; Council of Scientific and Industrial Research
   (CSIR) [BSC0103-UNDO]
FX The project was initiated under the Ramalingaswami Re-entry Individual
   Fellowships to SC and SKB by the Department of Biotechnology, India, and
   supported by the Council of Scientific and Industrial Research (CSIR)
   network projects [BSC0103-UNDO to SC, SKB and AK]. SM, PKB and BRR wish
   to thank CSIR for their SRFs. The authors would like to thank Pranav C
   Joshi for the help in preparing the manuscript.
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PU INDIAN ACAD SCIENCES
PI BANGALORE
PA C V RAMAN AVENUE, SADASHIVANAGAR, P B #8005, BANGALORE 560 080, INDIA
SN 0250-5991
EI 0973-7138
J9 J BIOSCIENCES
JI J. Biosci.
PD SEP
PY 2016
VL 41
IS 3
BP 407
EP 417
DI 10.1007/s12038-016-9627-8
PG 11
WC Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics
GA DT5HM
UT WOS:000381513000009
PM 27581932
DA 2025-06-11
ER

PT J
AU Minder, CM
   Shaya, GE
   Michos, ED
   Keenan, TE
   Blumenthal, RS
   Nasir, K
   Carvalho, JAM
   Conceiçao, RD
   Santos, RD
   Blaha, MJ
AF Minder, Camille Michael
   Shaya, Gabriel E.
   Michos, Erin D.
   Keenan, Tanya E.
   Blumenthal, Roger S.
   Nasir, Khurram
   Carvalho, Jose A. M.
   Conceicao, Raquel D.
   Santos, Raul D.
   Blaha, Michael J.
TI Relation Between Self-Reported Physical Activity Level, Fitness, and
   Cardiometabolic Risk
SO AMERICAN JOURNAL OF CARDIOLOGY
LA English
DT Article
ID CARDIORESPIRATORY FITNESS; ACTIVITY QUESTIONNAIRE;
   CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; EXERCISE CAPACITY;
   TREADMILL; VALIDITY; ASSOCIATION; MORTALITY; ADULTS
AB Physical activity and cardiorespiratory fitness are associated with improved cardiovascular health and reduced all-cause mortality. The relation between self-reported physical activity, objective physical fitness, and the association of each with cardiometabolic risk has not been fully described. We studied 2,800 healthy Brazilian subjects referred for an employer-sponsored health screening. Physical activity level was determined as "low," "moderate," or "high" with the International Physical Activity Questionnaire: Short Form (IPAQ-SF). Fitness was measured as METs achieved on a maximal, symptom-limited, treadmill stress test. Using multivariate linear regression analysis, we calculated age, gender, and smoking-adjusted correlation coefficients among IPAQ-SF, fitness, and cardiometabolic risk factors. Mean age of study participants was 43 +/- 9 years; 81% were men, and 43% were highly active. Mean METs achieved was 12 +/- 2. IPAQ-SF category and fitness were moderately correlated (r = 0.377). Compared with IPAQ-SF category, fitness was better correlated with cardiometabolic risk factors including anthropomorphic measurements, blood pressure, fasting blood glucose, dyslipidemia, high-sensitivity C-reactive protein, and hepatic steatosis (all p <0.01). Among these, anthropomorphic measurements, blood pressure, high-sensitivity C-reactive protein, and hepatic steatosis had the largest discrepancies in correlation, whereas lipid factors had the least discrepant correlation. When IPAQ-SF and fitness were discordant, poor fitness drove associations with elevated cardiometabolic risk. In conclusion, self-reported physical activity level and directly measured fitness are moderately correlated, and the latter is more strongly associated with a protective cardiovascular risk profile. (C) 2014 Elsevier Inc. All rights reserved.
C1 [Minder, Camille Michael; Shaya, Gabriel E.; Michos, Erin D.; Keenan, Tanya E.; Blumenthal, Roger S.; Nasir, Khurram; Blaha, Michael J.] Johns Hopkins Ciccarone Ctr Prevent Heart Dis, Baltimore, MD 21287 USA.
   [Shaya, Gabriel E.] Univ Miami, Miller Sch Med, Miami, FL 33136 USA.
   [Keenan, Tanya E.] Massachusetts Gen Hosp, Boston, MA 02114 USA.
   [Nasir, Khurram] Baptist Hlth South Florida, Miami, FL USA.
   [Carvalho, Jose A. M.; Conceicao, Raquel D.; Santos, Raul D.] Hosp Israelita Albert Einstein, Prevent Med Ctr, Sao Paulo, Brazil.
   [Santos, Raul D.] Univ Sao Paulo, Med Sch Hosp, Lipid Clin Heart Inst InCor, Sao Paulo, Brazil.
C3 Johns Hopkins University; Johns Hopkins Medicine; University of Miami;
   Harvard University; Harvard University Medical Affiliates; Massachusetts
   General Hospital; Hospital Israelita Albert Einstein; Universidade de
   Sao Paulo
RP Blaha, MJ (corresponding author), Johns Hopkins Ciccarone Ctr Prevent Heart Dis, Baltimore, MD 21287 USA.
EM mblaha1@jhmi.edu
RI Nasir, Khurram/A-2317-2008; Santos, Raul/A-1170-2010; Blumenthal,
   Roger/H-3223-2018
OI Keenan, Tanya/0000-0001-5300-9998; Michos, Erin/0000-0002-5547-5084
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NR 27
TC 49
Z9 60
U1 0
U2 30
PU EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
PI BRIDGEWATER
PA 685 ROUTE 202-206 STE 3, BRIDGEWATER, NJ 08807 USA
SN 0002-9149
EI 1879-1913
J9 AM J CARDIOL
JI Am. J. Cardiol.
PD FEB 15
PY 2014
VL 113
IS 4
BP 637
EP 643
DI 10.1016/j.amjcard.2013.11.010
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA AB4PQ
UT WOS:000331772800011
PM 24360775
DA 2025-06-11
ER

PT J
AU Seo, Y
   Je, Y
AF Seo, Yuri
   Je, Youjin
TI A comparative study on cardiovascular disease risk factors in Korean
   adults according to clinical depression status
SO PSYCHIATRY RESEARCH
LA English
DT Article
DE Depression; Body mass index; Metabolic syndrome; Cardiovascular disease
ID METABOLIC SYNDROME; MAJOR DEPRESSION; ALCOHOL-USE; ANXIETY;
   ASSOCIATIONS; DETERMINANTS; NUTRITION; SMOKING; OBESITY; HEALTH
AB This study was conducted to compare the association between depression and cardiovascular disease risk factors among Korean adults. This study was based on the data from the Korea National Health and Nutrition Examination Survey conducted in 2012-2014. Using a multivariable logistic regression model, we calculated odds ratios (ORs) and 95% confidence intervals (Cis). A total of 10,359 subjects aged 19-64 years were selected, and 432 subjects (74 men, 358 women) were included in the physician-diagnosed depression group. Several cardiovascular risk factors were associated with higher odds of clinical depression. For men, high waist circumference (>= 91.3 cm) and body mass index (>= 25.0 kg/m(2)) were significantly associated with increased odds of depression, and high physical activity (>= 50 MET h/week) was associated with decreased odds of depression. Men with dyslipidemia and metabolic syndrome had 2.43-fold and 2.0-fold higher odds of depression than those without the diseases. For women, current smokers had 2.25-fold higher odds of depression than nonsmokers, and frequent alcohol drinkers (>= 4 times/week) also had 2.88-fold higher odds of depression than nondrinkers. Korean adults with clinical depression had a higher prevalence of some risk factors for cardiovascular diseases than those without depression.
C1 [Seo, Yuri; Je, Youjin] Kyung Hee Univ, Dept Food & Nutr, 26 Kyunghee Daero, Seoul 02447, South Korea.
C3 Kyung Hee University
RP Je, Y (corresponding author), Kyung Hee Univ, Dept Food & Nutr, 26 Kyunghee Daero, Seoul 02447, South Korea.
EM youjinje@khu.ac.kr
RI Je, Youjin/N-2822-2018
OI Je, Youjin/0000-0002-2099-4204
FU Basic Science Research Program through the National Research Foundation
   of Korea - Ministry of Science, ICT and Future Planning
   [NRF-2015R1A1A1A05001362]
FX This work was supported by the Basic Science Research Program through
   the National Research Foundation of Korea, funded by the Ministry of
   Science, ICT and Future Planning (NRF-2015R1A1A1A05001362). Funders had
   no role in the study design, data collection and analysis, decision to
   publish, or preparation of the manuscript.
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NR 34
TC 7
Z9 8
U1 1
U2 6
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0165-1781
EI 1872-7123
J9 PSYCHIAT RES
JI Psychiatry Res.
PD MAY
PY 2018
VL 263
BP 88
EP 93
DI 10.1016/j.psychres.2018.02.052
PG 6
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA GF8PK
UT WOS:000432234600015
PM 29510344
DA 2025-06-11
ER

PT J
AU Batrakoulis, A
AF Batrakoulis, Alexios
TI Psychophysiological Adaptations to Yoga Practice in Overweight and Obese
   Individuals: A Topical Review
SO DISEASES
LA English
DT Review
DE yoga; exercise; overweight; obesity; physiological responses;
   psychological responses
ID LIFE-STYLE INTERVENTION; QUALITY-OF-LIFE; LOW-BACK-PAIN;
   PHYSICAL-ACTIVITY; MENTAL-HEALTH; MUSCULOSKELETAL FITNESS; METABOLIC
   SYNDROME; WORLDWIDE SURVEY; LIPID PROFILE; PUBLIC-HEALTH
AB Physical activity has been documented as a foundational approach for weight management and obesity, improving several cardiometabolic and mental health indices. However, it is not clear whether yoga practice can induce beneficial improvements in anthropometric and body composition parameters, performance, metabolic health, and well-being among overweight/obese people. The aim of this topical review was to catalog training studies examining the psychophysiological responses to yoga interventions in order to detect which outcomes have been investigated, the research methods applied, and the conclusions. The inclusion/exclusion criteria were met by 22 published articles involving 1178 (56% female) overweight/obese participants. This brief review on yoga-induced adaptations demonstrates that this widely used meditative movement activity can meaningfully improve the vast majority of the selected markers. These beneficial alterations are focused mostly on various anthropometric and body composition variables, cardiovascular disease risk factors, physical fitness parameters, quality of life, and stress in previously inactive overweight/obese individuals. Instead, yoga-based physical exercise interventions investigating anxiety, depression, mood state, exercise enjoyment, affect valence, and adherence were limited. Further research should focus on the yoga intervention configuration and potential mechanisms behind favorable changes in various psychophysiological indices through large-scale, rigorously designed randomized controlled trials implementing long-term interventions in overweight/obese individuals.
C1 [Batrakoulis, Alexios] Univ Thessaly, Dept Phys Educ & Sport Sci, Trikala 42100, Greece.
C3 University of Thessaly
RP Batrakoulis, A (corresponding author), Univ Thessaly, Dept Phys Educ & Sport Sci, Trikala 42100, Greece.
EM abatrakoulis@uth.gr
RI Batrakoulis, Alexios/AAE-4820-2022
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NR 148
TC 27
Z9 28
U1 1
U2 4
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
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J9 DISEASES-BASEL
JI Diseases
PD DEC
PY 2022
VL 10
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AR 107
DI 10.3390/diseases10040107
PG 21
WC Medicine, Research & Experimental
WE Emerging Sources Citation Index (ESCI)
SC Research & Experimental Medicine
GA 7D4GI
UT WOS:000900450400001
PM 36412601
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Maayan, L
   Kalanthroff, E
   Cohen, E
   Neria, Y
AF Maayan, Lawrence
   Kalanthroff, Eyal
   Cohen, Ezra
   Neria, Yuval
TI Potential metabolic sequelae to the terrorist attack of October 7th,
   2023
SO JOURNAL OF PSYCHIATRIC RESEARCH
LA English
DT Article
ID POSTTRAUMATIC-STRESS-DISORDER; ISRAELI CIVILIANS; SEXUAL VIOLENCE;
   MENTAL-HEALTH; EPIGENETIC REGULATION; PTSD; RISK; ASSOCIATION; LIFE;
   INTERVENTION
AB Objective/hypothesis: Evaluate cardiometabolic risk as a potential sequel to a mass terrorist attack using October 7th, 2023 as a focus. Methods: Narrative review surveying PubMed, PsycNet, UN and Council on Foreign Relations websites on. 1. PTSD following terrorism, rocket attacks and conflict related sexual violence. 2. The relationship between cardiometabolic illness and PTSD. 3. Humoral, genetic and epigenetic mechanisms relating cardiometabolic risk, inflammation and PTSD. 4. Treatments for PTSD and associated cardiometabolic risk factors and their effectiveness. Findings: Cardiometabolic sequelae occur after trauma. This is most pronounced when trauma, sexual or violence related, occurs during childhood. The risk of cardiometabolic sequelae increases with PTSD diagnosis in adults. Inflammation as well as genes related to inflammatory function (e.g. FKBP5, AHRR, NR3C1) impact vulnerability to PTSD, response to treatment and cardiometabolic outcomes. Treatments for PTSD appear somewhat more effective at lowering cardiometabolic risk in civilian, rather than military populations. There is little published research on directly treating cardiometabolic sequelae of PTSD. Conclusions: Israelis, particularly those with exposure to the terror events of October 7, 2023 should be screened for psychological and metabolic sequelae. This should occur in a primary care setting and be part of observational research to help understand relationships between trauma, metabolic outcomes and their treatment.
C1 [Maayan, Lawrence; Neria, Yuval] New York State Psychiat Inst & Hosp, 1051 Riverside Dr, New York, NY 10032 USA.
   [Kalanthroff, Eyal; Neria, Yuval] Columbia Coll Phys & Surg, Dept Psychiat, New York, NY USA.
   [Kalanthroff, Eyal] Hebrew Univ Jerusalem, Dept Psychol, Jerusalem, Israel.
   [Cohen, Ezra] SUNY Binghamton, Binghamton Univ, Binghamton, NY USA.
   [Neria, Yuval] Columbia Coll Phys & Surg, Dept Epidemiol, Columbia, NY USA.
C3 New York State Psychiatry Institute; Columbia University; Hebrew
   University of Jerusalem; State University of New York (SUNY) System;
   Binghamton University, SUNY
RP Maayan, L (corresponding author), New York State Psychiat Inst & Hosp, 1051 Riverside Dr, New York, NY 10032 USA.
EM Lawrence.maayan@nyspi.columbia.edu
FU New York State Psychiatric Institute
FX The authors wish to acknowledge the guidance of Dr. Franklin Schneier
   and the role of bridge funding at the New York State Psychiatric
   Institute in supporting the time used to prepare this manuscript.
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NR 114
TC 0
Z9 0
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U2 0
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-3956
EI 1879-1379
J9 J PSYCHIATR RES
JI J. Psychiatr. Res.
PD FEB
PY 2025
VL 182
BP 452
EP 461
DI 10.1016/j.jpsychires.2025.01.033
EA JAN 2025
PG 10
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA X2M4F
UT WOS:001423753200001
PM 39892214
DA 2025-06-11
ER

PT J
AU Arzoz-Fabregas, M
   Ibarz-Servio, L
   Edo-Izquierdo, S
   Doladé-Botías, M
   Fernandez-Castro, J
   Roca-Antonio, J
AF Arzoz-Fabregas, Montserrat
   Ibarz-Servio, Luis
   Edo-Izquierdo, Silvia
   Dolade-Botias, Maria
   Fernandez-Castro, Jordi
   Roca-Antonio, Josep
TI Chronic stress and calcium oxalate stone disease: is it a potential
   recurrence risk factor?
SO UROLITHIASIS
LA English
DT Article
DE Stress; Stone formers; First-time stone formers; Recurrent stone
   formers; Calcium oxalate
ID METABOLIC SYNDROME; PSYCHOMETRIC PROPERTIES; LIFE EVENTS; DEPRESSION;
   ANXIETY; SATISFACTION; SCALE
AB Chronic emotional stress is associated with increased cortisol release and metabolism disorders. However, few studies have evaluated the influence of chronic stress on calcium oxalate (CaOx) stone disease and its recurrence. A total of 128 patients were enrolled in this case-control study over a period of 20 months. All patients were CaOx stone formers with a recent stone episode (<3 months); 31 were first-time stone formers (FS) and 33 recurrent stone formers (RS). Dimensions of chronic stress were evaluated with self-reported validated questionnaires measuring stressful life events, perceived stress, anxiety, depression, burnout and satisfaction with life. An ad hoc self-reporting questionnaire was designed to evaluate stress-related specifically to stone episodes. Blood and urine samples were collected to determine cortisol levels and urinary composition. In addition, epidemiological data, socioeconomic information, diet and incidences of metabolic syndrome (MS) were reported. Overall, no significant differences were observed in the scores of cases and controls on any of the questionnaires dealing with stress. The number (p < 0.001) and the intensity (p < 0.001) of perceived stressful life events were higher in RS than in FS, but there were no differences between the two groups in other dimensions of stress. RS had higher glucose (p = 0.08), uric acid (p = 0.02), blood cortisol (p = 0.01), and urine calcium levels (p = 0.01) than FS. RS also had lower economic levels (p = 0.02) and more frequent incidences of MS (p = 0.07) than FS. Although no differences were observed in cases and controls among any dimension of chronic stress, the number and intensity of stressful life events were higher in RS than in FS. These differences correlate with variations in blood and urinary levels and with metabolic disorders, indicating an association between chronic stress and risk of recurrent CaOx stone formation.
C1 [Arzoz-Fabregas, Montserrat; Ibarz-Servio, Luis] Hosp Badalona Germans Trias & Pujol, Dept Urol, Badalona 08916, Barcelona, Spain.
   [Edo-Izquierdo, Silvia; Fernandez-Castro, Jordi] Autonomous Univ Barcelona, Dept Psychol, Bellaterra, Spain.
   [Dolade-Botias, Maria] Hosp Badalona Germans Trias & Pujol, Dept Biochem, Badalona 08916, Barcelona, Spain.
   [Roca-Antonio, Josep] Hosp Badalona Germans Trias & Pujol, Dept Epidemiol, Badalona 08916, Barcelona, Spain.
C3 Hospital Germans Trias i Pujol; Autonomous University of Barcelona;
   Hospital Germans Trias i Pujol; Hospital Germans Trias i Pujol
RP Arzoz-Fabregas, M (corresponding author), Hosp Badalona Germans Trias & Pujol, Dept Urol, Crta Canyet S-N, Badalona 08916, Barcelona, Spain.
EM montsearzoz@hotmail.com
RI ; Edo, Silvia/L-3271-2014; Fernandez-Castro, Jordi/L-6166-2014
OI Arzoz, Montserrat/0000-0002-6438-4870; Edo, Silvia/0000-0002-6564-3475;
   Fernandez-Castro, Jordi/0000-0001-7725-3506; Dolade Botias,
   Maria/0000-0001-8263-3087
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NR 31
TC 7
Z9 7
U1 0
U2 15
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 2194-7228
EI 2194-7236
J9 UROLITHIASIS
JI Urolithiasis
PD APR
PY 2013
VL 41
IS 2
BP 119
EP 127
DI 10.1007/s00240-013-0544-0
PG 9
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 136CD
UT WOS:000318336500004
PM 23503873
DA 2025-06-11
ER

PT J
AU Ward, T
   Wynaden, D
   Heslop, K
AF Ward, Tamara
   Wynaden, Dianne
   Heslop, Karen
TI Who is responsible for metabolic screening for mental health clients
   taking antipsychotic medications?
SO INTERNATIONAL JOURNAL OF MENTAL HEALTH NURSING
LA English
DT Article
DE audit; leadership; mental health nursing; metabolic screening; metabolic
   syndrome
ID PHYSICAL HEALTH; PRIMARY-CARE; NURSES ATTITUDES; TRAINING NEEDS; PEOPLE;
   ILLNESS; CONSUMERS; SCHIZOPHRENIA; GUIDELINES; PSYCHOSIS
AB Metabolic syndrome is common in mental health consumer populations, and is linked to cardiovascular disease, stroke and diabetes. Metabolic screening is a way of recognising consumers who are at risk of developing metabolic syndrome but internationally screening rates remain low. A retrospective audit was completed at one Australian public mental health service on the case files of 100 randomly selected consumers to determine nurses level of compliance with metabolic screening policies over a 12month period. Consumers included in the review were prescribed antipsychotic medications for at least 12months and had their care in the community coordinated by mental health nurses. Data were entered into an Excel spreadsheet for analysis. Low levels of metabolic screening were identified and these levels decreased over the 12months under review. No consumers had metabolic screening that recorded all parameters at three monthly intervals over the 12month period. Only one consumer had every metabolic parameter recorded on the physical health screen tool at baseline assessment. The findings demonstrated that while there is increased awareness of co-morbid physical health issues in this consumer population, the translation of guidelines and policy directives to clinical practice to address this disparity remains low. Improving physical health outcomes is the responsibility of all health professionals, particularly doctors who prescribe and nurses who administer antipsychotic medications regularly to mental health consumers. Moreover, nurses are well placed to demonstrate leadership in reducing the rate of metabolic syndrome through the delivery of holistic care that includes effective screening programs.
C1 [Ward, Tamara; Wynaden, Dianne; Heslop, Karen] Curtin Univ, Nursing Midwifery & Paramed, Perth, WA, Australia.
C3 Curtin University
RP Wynaden, D (corresponding author), Curtin Univ, Sch Nursing Midwifery & Paramed, GPO Box U 1987, Perth, WA 6845, Australia.
EM d.wynaden@curtin.edu.au
RI Heslop, Karen/AFM-4040-2022
OI Wynaden, Dianne/0000-0002-3985-7621; Heslop, Karen/0000-0002-1136-3718
CR Australian Commission on Quality and Safety in Health Care, 2014, AC MENT HLTH CAR QUM
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NR 42
TC 17
Z9 18
U1 0
U2 14
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1445-8330
EI 1447-0349
J9 INT J MENT HEALTH NU
JI Int. J. Ment. Health Nurs.
PD FEB
PY 2018
VL 27
IS 1
BP 196
EP 203
DI 10.1111/inm.12309
PG 8
WC Nursing; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Psychiatry
GA FS3XF
UT WOS:000419717100019
PM 28093900
DA 2025-06-11
ER

PT J
AU Adebajo, SB
   Adebiyi, R
   Chama, J
   Bello, S
   Ononaku, U
   Aka, A
   Lai, SH
   Baral, SD
   Dyer, TV
   Crowell, TA
   Nowak, RG
   Charurat, M
AF Adebajo, Sylvia B. B.
   Adebiyi, Ruxton
   Chama, John
   Bello, Segun
   Ononaku, Uche
   Aka, Abayomi
   Lai, Shenghan
   Baral, Stefan D. D.
   Dyer, Typhanye V. V.
   Crowell, Trevor A. A.
   Nowak, Rebecca G. G.
   Charurat, Man
CA TRUST RV368 Study Grp
TI Depression and Sexual Stigma Are Associated With Cardiometabolic Risk
   Among Sexual and Gender Minorities Living With HIV in Nigeria
SO JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
LA English
DT Article
DE sexual and gender minorities living with HIV; sexual stigma; depression;
   cardiometabolic diseases; syndemics; Nigeria
ID SUB-SAHARAN AFRICA; METABOLIC SYNDROME; MEN; PREVALENCE; DISEASE;
   HEALTH; DISCRIMINATION; INFLAMMATION; INFECTIONS; DEFINITION
AB Background:People living with HIV are vulnerable to cardiometabolic diseases. We assessed the prevalence of cardiometabolic risk factors (CMRF) and associations with sexual stigma and depression among sexual and gender minorities (SGM) in Abuja and Lagos, Nigeria.Methods:The TRUST/RV368 study enrolled SGM between March 2013 and February 2020. Participants were assessed for depression, sexual stigma, and CMRF. Robust multinomial logistic regression was used to estimate adjusted odds ratio (aORs) and 95% confidence intervals (CIs) for associations of depression, sexual stigma, and other factors with increasing numbers of CMRF.Results:Among 761 SGM, the mean age was 25.0 +/- 6.0 years; 580 (76%) identified as cisgender men, 641 (84%) had >= 1 CMRF, 355 (47%) had mild-severe depression, and 405 (53%) reported moderate-high sexual stigma. Compared with individuals without depression, those with mild (aOR 8.28; 95% CI: 4.18 to 16.40) or moderate-severe depression (aOR 41.69; 95% CI: 9.60 to 181.04) were more likely to have 3-5 CMRF. Individuals with medium (aOR 3.17; 95% CI: 1.79 to 5.61) and high sexual stigma (aOR 14.42; 95% CI: 2.88 to 72.29) compared with those with low sexual stigma were more likely to have 3-5 CMRF. Participants age 25-34 years were less likely to have 3-5 CMRF (aOR 0.41; 95% CI: 0.23 to 0.73) compared with participants age younger than 25 years.Conclusion:CMRF increased with severity of depression and sexual stigma, potentially predisposing SGM living with HIV to cardiometabolic diseases. Integrating interventions that address depression and sexual stigma in HIV care programs for SGM may improve cardiometabolic outcomes.
C1 [Adebajo, Sylvia B. B.; Adebiyi, Ruxton; Chama, John; Bello, Segun] Univ Maryland Baltimore, Ctr Int Hlth Educ Biosecur, 129 Yakubu Gowon Way, Abuja, Nigeria.
   [Ononaku, Uche] Inst Human Virol, Abuja, Nigeria.
   [Aka, Abayomi] ICARH, Abuja, Nigeria.
   [Lai, Shenghan; Nowak, Rebecca G. G.; Charurat, Man] Univ Maryland, Inst Human Virol, Sch Med, Baltimore, MD USA.
   [Baral, Stefan D. D.] Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD USA.
   [Dyer, Typhanye V. V.] Univ Maryland, Sch Publ Hlth, College Pk, MD USA.
   [Crowell, Trevor A. A.] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA.
   [Crowell, Trevor A. A.] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA.
   [Charurat, Man] Univ Maryland, Ctr Int Hlth Educ Biosecur, Sch Med, Baltimore, MD USA.
C3 University System of Maryland; University of Maryland Baltimore; Johns
   Hopkins University; Johns Hopkins Bloomberg School of Public Health;
   University System of Maryland; University of Maryland College Park;
   Henry M. Jackson Foundation for the Advancement of Military Medicine,
   Inc; United States Department of Defense; United States Army; Walter
   Reed Army Institute of Research (WRAIR); University System of Maryland;
   University of Maryland Baltimore
RP Adebajo, SB (corresponding author), Univ Maryland Baltimore, Ctr Int Hlth Educ Biosecur, 129 Yakubu Gowon Way, Abuja, Nigeria.
EM SAdebajo@mgic.umaryland.edu; ARuxton@mgic.umaryland.edu;
   JChama@mgic.umaryland.edu; drsegunbello@yahoo.com; uche.trust@gmail.com;
   aaka@icarh.org; SLai@ihv.umaryland.edu; sbaral@jhu.edu;
   typhanye@umd.edu; tcrowell@hivresearch.org; RNowak@ihv.umaryland.edu;
   MCharurat@ihv.umaryland.edu
RI Adebiyi, Ruxton/GLV-2986-2022; Crowell, Trevor/W-3904-2019
OI Adebajo, Sylvia/0000-0002-5933-8044; Adebiyi, Ruxton/0000-0002-1398-7057
FU Henry M. Jackson Foundation for the Advancement of Military Medicine,
   Inc; U.S. Department of Defense [W81XWH-11-2-0174, W81XWH-18-2-0040];
   National Institutes of Health [R01 MH099001, R01 AI120913, R01 MH110358,
   K07CA225403, R01HL165686]; Fogarty Epidemiology Research Training for
   Public Health Impact in Nigeria program [D43TW010051]; Institute for
   Human Virology-Nigeria [NU2GGH002099]; Department of Health and Human
   Services/Centers for Disease Control and Prevention; Global AIDS Program
FX Supported by cooperative agreements between the Henry M. Jackson
   Foundation for the Advancement of Military Medicine, Inc., and the U.S.
   Department of Defense [W81XWH-11-2-0174, W81XWH-18-2-0040]; the National
   Institutes of Health [R01 MH099001, R01 AI120913, R01 MH110358,
   K07CA225403, and R01HL165686]; Fogarty Epidemiology Research Training
   for Public Health Impact in Nigeria program [D43TW010051]; and the
   President's Emergency Plan for AIDS Relief through a cooperative
   agreement between the Department of Health and Human Services/Centers
   for Disease Control and Prevention, Global AIDS Program, and the
   Institute for Human Virology-Nigeria [NU2GGH002099].
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NR 64
TC 3
Z9 3
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1525-4135
EI 1077-9450
J9 JAIDS-J ACQ IMM DEF
JI JAIDS
PD JAN 1
PY 2023
VL 92
IS 1
BP 50
EP 58
DI 10.1097/QAI.0000000000003096
PG 9
WC Immunology; Infectious Diseases
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Infectious Diseases
GA 6Z0EU
UT WOS:000897457800009
PM 36150037
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Mommersteeg, PMC
   Pot, I
   Aarnoudse, W
   Denollet, J
   Widdershoven, JW
AF Mommersteeg, Paula M. C.
   Pot, Irene
   Aarnoudse, Wilbert
   Denollet, Johan
   Widdershoven, Jos W.
TI Type D personality and patient-perceived health in nonsignificant
   coronary artery disease: the TWeesteden mIld STenosis (TWIST) study
SO QUALITY OF LIFE RESEARCH
LA English
DT Article
DE Mild stenosis; Nonsignificant coronary artery disease; Type D
   personality; Chest pain; Health status; General distress
ID RISK-FACTORS; NEGATIVE AFFECTIVITY; METABOLIC SYNDROME; SOCIAL
   INHIBITION; DEPRESSION SCALE; HOSPITAL ANXIETY; NATIONAL-HEART;
   CHEST-PAIN; ANGINA; PREVALENCE
AB To examine whether Type D-distressed-personality is independently associated with patient reported health outcomes, such as chest pain, health status and emotional distress, in patients with angiographically nonsignificant coronary abnormalities. Psychosocial factors, such as Type D personality, are risk factors for established coronary artery disease (CAD), but are unknown for patients with non-obstructive CAD.
   A total of 273 patients (62 years, SD 10, 49 % male) participated in the cross-sectional part of the 'TWeesteden mIld STenosis' study. Inclusion was based on coronary angiography or CT-scan. Type D personality was examined in relation to chest pain, disease-specific (Seattle Angina Questionnaire) and generic health status (Short Form 12), and emotional distress (Hospital Anxiety and Depression Scale, Fatigue), adjusted for confounders and potential explanatory lifestyle factors.
   Patients with Type D personality (30 %) had an increased prevalence of chest pain (57 vs. 40 %). When adjusted for confounder's age, gender, comorbidity, and medication use, Type D personality was significantly associated with increased chest pain, poorer disease-specific and generic health status and increased emotional distress. After further adjustment for explanatory lifestyle factors such as smoking, physical activity, and metabolic syndrome, Type D personality was associated with worse disease perception, lower treatment satisfaction, poor physical and mental health status, and higher emotional distress, but no longer with chest pain, angina stability, or physical limitations.
   Type D personality was significantly associated with poor patient-perceived symptoms in patients with mild coronary abnormalities, which can be hypothesized to be detrimental in the long run.
C1 [Mommersteeg, Paula M. C.; Pot, Irene; Denollet, Johan] Tilburg Univ, Dept Med & Clin Psychol, CoRPS, Ctr Res Psychol Somat Dis, Warandelaan 2,POB 90153, NL-5000 LE Tilburg, Netherlands.
   [Aarnoudse, Wilbert; Widdershoven, Jos W.] TweeSteden Hosp, Dept Cardiol, NL-5042 AD Tilburg, Netherlands.
C3 Tilburg University; Elisabeth-TweeSteden Ziekenhuis (ETZ)
RP Mommersteeg, PMC (corresponding author), Tilburg Univ, Dept Med & Clin Psychol, CoRPS, Ctr Res Psychol Somat Dis, Warandelaan 2,POB 90153, NL-5000 LE Tilburg, Netherlands.
EM P.M.C.Mommersteeg@tilburguniversity.edu
RI Mommersteeg, Paula/AAB-7801-2019
FU BIOTRONIK Nederland B.V.
FX The authors would like to thank the staff and employees of the
   TweeSteden Hospital Cardiology, laboratory, CAG and CT units. The
   authors would like to thank Tilburg University research assistants
   Sylvie Teurlings, Marjanne Bakker, Fleur Kuipers, Ferry van Eekelen, and
   Laura G. A. M. van Doornmalen for their contribution in the data
   collection of this study. P. M. C. M. received a travel grant of 250
   euro of BIOTRONIK Nederland B.V.
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NR 38
TC 12
Z9 15
U1 0
U2 6
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0962-9343
EI 1573-2649
J9 QUAL LIFE RES
JI Qual. Life Res.
PD OCT
PY 2013
VL 22
IS 8
BP 2041
EP 2050
DI 10.1007/s11136-012-0340-2
PG 10
WC Health Care Sciences & Services; Health Policy & Services; Public,
   Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services; Public, Environmental & Occupational
   Health
GA 253HC
UT WOS:000327073900016
PM 23263915
DA 2025-06-11
ER

PT J
AU Armato, J
   Defronzo, RA
   Abdul-Ghani, M
   Ruby, R
AF Armato, John
   Defronzo, Ralph A.
   Abdul-Ghani, Muhammad
   Ruby, Ron
TI Pre-Prediabetes: Insulin Resistance Is Associated With Cardiometabolic
   Risk in Nonobese Patients (STOP DIABETES)
SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Article
DE insulin resistance; prediabetes; cardiometabolic risk
ID ENDOPLASMIC-RETICULUM STRESS; METABOLIC SYNDROME; GLUCOSE-TOLERANCE;
   ATHEROSCLEROSIS; DIAGNOSIS; HYPERINSULINEMIA; SENSITIVITY; INTOLERANCE;
   OBESITY; NIDDM
AB Context Prior studies have demonstrated glycemic and cardiometabolic risk in the prediabetic state.Objective This work aims to examine if insulin resistance (IR) is associated with markers of glycemic, cardiometabolic, and atherosclerotic risk in nonobese, nonprediabetic individuals compared to insulin-sensitive (IS) individuals matched for body mass index (BMI), sex, and age.Methods Of 1860 patients from the STOP DIABETES study, 624 had normal fasting plasma glucose, BMI less than 30, and glycated hemoglobin A1c (HbA1c) less than 5.7%. All received an oral glucose tolerance test. Insulin sensitivity was quantitated using the Matsuda index: less than the 25th percentile equals IR (n = 151) and 25th percentile or greater equals IS (n = 473). Measures of dysglycemia and cardiometabolic risk were compared between IR individuals (n = 151) and a subset of IS individuals who were matched for BMI, sex, and age (n = 151). Carotid intima media thickness and carotid plaque were measured in 65 IR and 76 IS individuals.Results Compared to matched IS patients, IR nonobese individuals demonstrated increased indicators of glycemic and cardiometabolic risk, including increased 60-minute plasma glucose and percentage of patients with 60-minute plasma glucose greater than 155 mg/dL; increased 120-minute plasma glucose; unrecognized impaired glucose tolerance and type 2 diabetes, decreased disposition index; increased systolic and diastolic blood pressure; elevated plasma triglycerides (TGs); reduced high-density lipoprotein (HDL) cholesterol; increased TGs/HDL ratio, and high-sensitivity C-reactive protein. The presence, size, and number of carotid plaques was greater in the IR group.Conclusion Approximately 1 in 4 nonobese patients in this population with normal fasting glucose and HbA1c were IR. In these nonobese participants, IR was associated with multiple indicators of dysglycemia and cardiometabolic risk.
C1 [Armato, John; Ruby, Ron] Providence Little Co Mary Cardiometab Ctr, Providence Med Associates, Torrance, CA 90503 USA.
   [Defronzo, Ralph A.; Abdul-Ghani, Muhammad] Univ Texas Hlth Sci Ctr San Antonio, Diabet Div, San Antonio, TX 78207 USA.
   [Defronzo, Ralph A.; Abdul-Ghani, Muhammad] Texas Diabet Inst, San Antonio, TX 78207 USA.
C3 University of Texas System; University of Texas Health Science Center at
   San Antonio
RP Armato, J (corresponding author), Providence Hlth & Serv, 520 N Prospect S200, Redondo Beach, CA 90277 USA.
EM dr.armato@gmail.com
OI DeFronzo, Ralph/0000-0002-8581-6273
CR Abdul-Ghani MA, 2006, DIABETES, V55, P1430, DOI 10.2337/db05-1200
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NR 34
TC 0
Z9 0
U1 3
U2 4
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0021-972X
EI 1945-7197
J9 J CLIN ENDOCR METAB
JI J. Clin. Endocrinol. Metab.
PD MAY
PY 2025
VL 110
IS 5
BP e1481
EP e1487
DI 10.1210/clinem/dgae540
EA AUG 2024
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 1TR3H
UT WOS:001291636000001
PM 39109850
OA Bronze
DA 2025-06-11
ER

PT J
AU Naicker, K
   Manuel, D
   Overland, S
   Skogen, JC
   Johnson, JA
   Sivertsen, B
   Colman, I
AF Naicker, Kiyuri
   Manuel, Douglas
   Overland, Simon
   Skogen, Jens C.
   Johnson, Jeffrey A.
   Sivertsen, Borge
   Colman, Ian
TI Population attributable fractions for Type 2 diabetes: an examination of
   multiple risk factors including symptoms of depression and anxiety
SO DIABETOLOGY & METABOLIC SYNDROME
LA English
DT Article
DE Type 2 diabetes; Attributable fractions; Depression; Anxiety; Metabolic
   risk
ID METABOLIC SYNDROME; HEART-DISEASE; OBESITY; ASSOCIATION; MORTALITY;
   PROFILE; LIFE
AB BackgroundPopulation attributable fractions (PAFs) are frequently used to quantify the proportion of Type 2 diabetes cases due to single risk factors, an approach which may result in an overestimation of their individual contributions. This study aimed to examine Type 2 diabetes incidence associated with multiple risk factor combinations, including the metabolic syndrome, behavioural factors, and specifically, depression and anxiety.MethodsUsing data from the population-based HUNT cohort, we examined incident diabetes in 36,161 Norwegian adults from 1995 to 2008. PAFs were calculated using Miettinen's case-based formula, using relative risks estimated from multivariate regression models.ResultsOverall, the studied risk factors accounted for 50.5% of new diabetes cases (78.2% in men and 47.0% in women). Individuals exposed to both behavioural and metabolic factors were at highest risk of diabetes onset (PAF=22.9%). Baseline anxiety and depression contributed a further 13.6% of new cases to this combination. Men appeared to be particularly vulnerable to the interaction between metabolic, behavioural and psychological risk factors.ConclusionThis study highlights the importance of risk factor clustering in diabetes onset, and is the first that we know of to quantify the excess fraction of incident diabetes associated with psychological risk factor interactions.
C1 [Naicker, Kiyuri; Colman, Ian] Univ Ottawa, Sch Epidemiol & Publ Hlth, 600 Peter Morand Cres,Room 308C, Ottawa, ON K1G 5Z3, Canada.
   [Manuel, Douglas] Ottawa Hosp Res Inst, Ottawa, ON, Canada.
   [Overland, Simon; Skogen, Jens C.; Sivertsen, Borge] Norwegian Inst Publ Hlth, Dept Hlth Promot, Bergen, Norway.
   [Overland, Simon] Univ Bergen, Dept Psychosocial Sci, Bergen, Norway.
   [Skogen, Jens C.] Stavanger Univ Hosp, Ctr Alcohol & Drug Res, Stavanger, Norway.
   [Johnson, Jeffrey A.] Univ Alberta, Sch Publ Hlth, Edmonton, AB, Canada.
   [Sivertsen, Borge] Helse Fonna HF, Dept Res & Innovat, Haugesund, Norway.
   [Sivertsen, Borge] Uni Res Hlth, Reg Ctr Child & Youth Mental Hlth & Child Welf, Bergen, Norway.
C3 University of Ottawa; University of Ottawa; Ottawa Hospital Research
   Institute; Norwegian Institute of Public Health (NIPH); University of
   Bergen; Stavanger University Hospital; University of Alberta
RP Colman, I (corresponding author), Univ Ottawa, Sch Epidemiol & Publ Hlth, 600 Peter Morand Cres,Room 308C, Ottawa, ON K1G 5Z3, Canada.
EM icolman@uottawa.ca
RI Colman, Ian/AFK-4708-2022; Skogen, Jens Christoffer/LPR-0817-2024;
   Øverland, Simon/ABF-1289-2020; Sivertsen, Borge/JRY-4994-2023; Manuel,
   Doug/D-7100-2014
OI Overland, Simon/0000-0001-6967-9355; Sivertsen,
   Borge/0000-0003-4654-9296; Manuel, Doug/0000-0003-0912-0845; Colman,
   Ian/0000-0001-5924-0277; Skogen, Jens Christoffer/0000-0003-0722-5440
FU Canada Research Chairs program; Ontario Mental Health Foundation;
   Alberta Innovates Health Solutions
FX This work was supported in part by funding from the Canada Research
   Chairs program for IC, and by an Ontario Mental Health Foundation
   doctoral award held by KN. JAJ holds a Senior Health Scholar award from
   Alberta Innovates Health Solutions.
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NR 46
TC 10
Z9 10
U1 0
U2 6
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1758-5996
J9 DIABETOL METAB SYNDR
JI Diabetol. Metab. Syndr.
PD NOV 22
PY 2018
VL 10
AR 84
DI 10.1186/s13098-018-0387-5
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA HB4OC
UT WOS:000451032000001
PM 30479670
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Tso, G
   Kumar, P
   Jayasooriya, T
   Kisely, S
   Siskind, D
AF Tso, Grace
   Kumar, Puja
   Jayasooriya, Thilini
   Kisely, Steve
   Siskind, Dan
TI Metabolic monitoring and management among clozapine users
SO AUSTRALASIAN PSYCHIATRY
LA English
DT Article
DE metabolic syndrome; clozapine; antipsychotic; psychosis; metabolic
   monitoring
ID DEFINITION
AB Objective: To assess, among clozapine users, the rates of monitoring, presence and treatment of metabolic syndrome and its components.
   Methods: A chart review was conducted of all clozapine users who were followed up in community mental health clinics at two Metro South Health Hospitals over a 1-year period. Metabolic syndrome was diagnosed according to the International Diabetes Federation criteria.
   Results: We included 251 clozapine users. Only 43.4% (109/251) had data collected for all five metabolic syndrome parameters. Among these people, 45.0% (49/109) met criteria for metabolic syndrome, while 61.2% (30/49) of those with metabolic syndrome were offered appropriate treatments. Correspondence with primary care providers occurred in only 18.7% (n = 47). Non-pharmacological interventions, such as motivational interviewing and education about healthy lifestyle alternatives, occurred in 49.8% (n = 125).
   Conclusions: There is growing awareness of the importance of metabolic monitoring, however, there remain specific gaps in the collaborative work among mental health services, primary care providers and clozapine users, to ensure appropriate physical health interventions.
C1 [Tso, Grace; Kumar, Puja; Jayasooriya, Thilini; Kisely, Steve; Siskind, Dan] Metro South Addict & Mental Hlth Serv, Psychiat, Brisbane, Qld, Australia.
   [Jayasooriya, Thilini] Dist Gen Hosp Trincomalee, Trincomalee, Sri Lanka.
   [Kisely, Steve; Siskind, Dan] Univ Queensland, Sch Med, Brisbane, Qld, Australia.
C3 University of Queensland
RP Tso, G (corresponding author), Princess Alexandra Hosp, Metro South Addict & Mental Hlth Serv, 199 Ipswich Rd, Woolloongabba, Qld 4102, Australia.
EM grace.tso@health.qld.gov.au
RI Kisely, Steve/B-4680-2012; Siskind, Dan/A-9812-2014
OI Siskind, Dan/0000-0002-2072-9216
CR Agid O, 2011, J CLIN PSYCHIAT, V72, P1439, DOI 10.4088/JCP.09m05785yel
   Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
   Brown S, 1997, BRIT J PSYCHIAT, V171, P502, DOI 10.1192/bjp.171.6.502
   Druss BG, 2002, MED CARE, V40, P129, DOI 10.1097/00005650-200202000-00007
   Forrester T, 2015, PHARMACOPSYCHIATRY, V48, P164, DOI 10.1055/s-0035-1554713
   Goldenberg R, 2013, CAN J DIABETES, V37, pS8, DOI 10.1016/j.jcjd.2013.01.011
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   Mitchell AJ, 2013, SCHIZOPHRENIA BULL, V39, P306, DOI 10.1093/schbul/sbr148
   Siskind D, 2016, BRIT J PSYCHIAT, V209, P387, DOI 10.1192/bjp.bp.115.177261
NR 11
TC 19
Z9 19
U1 0
U2 1
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1039-8562
EI 1440-1665
J9 AUSTRALAS PSYCHIATRY
JI Australas. Psychiatry
PD FEB
PY 2017
VL 25
IS 1
BP 48
EP 52
DI 10.1177/1039856216665282
PG 5
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA EL8ZI
UT WOS:000394908500013
PM 27590080
DA 2025-06-11
ER

PT J
AU Alkazemi, D
   Egeland, GM
   Roberts, LJ
   Kubow, S
AF Alkazemi, Dalal
   Egeland, Grace M.
   Roberts, Lyman Jackson, II
   Kubow, Stan
TI Isoprostanes and isofurans as non-traditional risk factors for
   cardiovascular disease among Canadian Inuit
SO FREE RADICAL RESEARCH
LA English
DT Article
DE isoprostanes; isofurans; oxidative stress; CRP; Inuit; metabolic
   syndrome
ID HYPERTRIGLYCERIDEMIC-WAIST PHENOTYPE; OXIDATIVE STRESS; OXIDANT STRESS;
   METABOLIC-SYNDROME; LIPID-PEROXIDATION; BIOLOGICAL-FLUIDS; CIRCUMPOLAR
   INUIT; BLOOD-PRESSURE; TISSUE OXYGEN; HEALTH SURVEY
AB Objectives: The aim of the present study was to investigate the potential importance of oxidative stress, measured by isoprostanes-related compounds, as non-traditional risk factor for cardiovascular disease. We planned to examine the relationship between concentrations of plasma F-2- isoprostanes (F-2-IsoPs), isofurans (IsoFs), measures of obesity and various cardiometabolic risk factors. Materials and methods: Cross-sectional study using a sub-sample from the population of a survey conducted in the summer and fall 2007 and 2008 by Canadian Coastguard Ship Amundsen in 36 Canadian Arctic Inuit communities. Subjects included a subset (n = 233) of a total study population (n = 2595) with a mean age 42.56 +/- 15.39 years and body mass index 27.78 +/- 5.65 kg/m(2). Plasma levels of F-2-IsoPs and IsoFs was determined by gas chromatography/ negative ion chemical ionization/mass spectrometry (GC/NICI/MS) method; and their relationships to waist circumference (WC), blood pressure C reactive proteins (CRP), blood lipids and fasting glucose were assessed by multivariate analyses. Results: Plasma F-2-IsoPs correlated positively with CRP (r = .132, P = .048) and systolic blood pressure (SBP) (r = .157, P = .024) after adjustment for age, sex and body mass index. IsoFs correlated with WC (r = .190, P = .005) and SBP (r = .137, P = .048). F-2-IsoPs were not found elevated in smokers (P = .034), whereas IsoFs were decreased in smokers (P = .001). WC, SBP and sex were found to be major correlates of oxidative stress in Canadian Inuit. Conclusions: Plasma measures of F-2-IsoPs and IsoFs increase with increased obesity and associated cardiometabolic risk factors, including CRP and blood pressure. Simultaneous measurement of IsoFs provides an advantageous mechanistic insight into oxidative stress not captured by F-2-IsoPs alone.
C1 [Alkazemi, Dalal; Kubow, Stan] McGill Univ, Sch Dietet & Human Nutr, Ste Anne De Bellevue, PQ H9X 3V9, Canada.
   [Alkazemi, Dalal; Kubow, Stan] McGill Univ, Ctr Indigenous Peoples Nutr & Environm, Ste Anne De Bellevue, PQ H9X 3V9, Canada.
   [Egeland, Grace M.] Univ Bergen, Norwegian Inst Publ Hlth, Bergen, Norway.
   [Egeland, Grace M.] Univ Bergen, Fac Med & Dent, Bergen, Norway.
   [Roberts, Lyman Jackson, II] Vanderbilt Univ, Dept Pharmacol, Nashville, TN USA.
   [Roberts, Lyman Jackson, II] Vanderbilt Univ, Dept Med, Nashville, TN USA.
C3 McGill University; McGill University; University of Bergen; Norwegian
   Institute of Public Health (NIPH); University of Bergen; Vanderbilt
   University; Vanderbilt University
RP Kubow, S (corresponding author), McGill Univ, Sch Dietet & Human Nutr, 21,111 Lakeshore Rd, Ste Anne De Bellevue, PQ H9X 3V9, Canada.
EM stan.kubow@mcgill.ca
RI Kubow, Stan/AAJ-6913-2021; Alkazemi, Dalal Usamah Zaid/E-5481-2018
OI Alkazemi, Dalal Usamah Zaid/0000-0001-9349-2144; Kubow,
   Stan/0000-0001-5831-9880
FU Government of Canada Federal Program for International Polar Year;
   Canadian Institutes of Health Research, Health Canada; Aboriginal
   Affairs and Northern Development Canada; Government of Nunavut;
   University of Toronto; Arctic Net
FX Funding for this work has been provided by Government of Canada Federal
   Program for International Polar Year, Canadian Institutes of Health
   Research, Health Canada, Aboriginal Affairs and Northern Development
   Canada, Government of Nunavut, University of Toronto, and Arctic Net.
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NR 41
TC 13
Z9 13
U1 0
U2 5
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 1071-5762
J9 FREE RADICAL RES
JI Free Radic. Res.
PD OCT
PY 2012
VL 46
IS 10
BP 1258
EP 1266
DI 10.3109/10715762.2012.702900
PG 9
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 008HG
UT WOS:000308947400009
PM 22712480
DA 2025-06-11
ER

PT J
AU Kuo, WC
   Bratzke, LC
   Hagen, EW
   Hale, L
   Brown, RL
   Barnet, JH
   Peppard, PE
AF Kuo, Wan-Chin
   Bratzke, Lisa. C.
   Hagen, Erika W. W.
   Hale, Lauren
   Brown, Roger L. L.
   Barnet, Jodi H. H.
   Peppard, Paul E. E.
TI Metabolic health disparities driven by financial stress: Behavioural
   adaptation or modification?
SO STRESS AND HEALTH
LA English
DT Article
DE financial stress; metabolic syndrome; physical activity; sleep duration
ID PHYSICAL-ACTIVITY; SLEEP DURATION; ASSOCIATIONS; RISK; MODERATOR;
   MEDIATOR; STRAIN; PREVALENCE; DEPRESSION; GLUCOSE
AB Financial stress has been linked to an increased risk of metabolic syndrome, yet, it remains unclear whether suboptimal sleep duration and physical inactivity are the adaptive responses to financial stress or effect modifiers in the association between financial stress and metabolic syndrome. Hence, this study aims to examine whether physical activity and sleep duration mediate or moderate the bivariate association between financial stress and metabolic syndrome. A prospective secondary analysis was conducted using data from the Wisconsin Sleep Cohort Study (N = 445, mean [SD] age = 64 [7] years). Baseline moderation effect was examined using subgroup analysis with model constraints; prospective mediation model was examined using bias-corrected bootstrap confidence intervals. Results indicate that participants with higher financial stress were less likely to meet physical activity and sleep recommendations. Baseline moderation analysis indicates that meeting current recommendations of sleep duration and physical activity attenuated the association between financial stress and metabolic syndrome. In the prospective mediation analysis, weekly physical activity levels partially mediated the relationship between financial stress and metabolic syndrome, but sleep duration did not mediate this relationship. In conclusion, the joint effect of optimal sleep duration and physical activity disassociates financial stress from the risk of metabolic syndrome. Future interventions addressing metabolic risk might achieve better outcomes if clinicians and researchers factor in the behavioral adaptation of physical inactivity in financially stressed adults (Clinical Trial Registration: NCT00005557).
C1 [Kuo, Wan-Chin; Bratzke, Lisa. C.; Brown, Roger L. L.] Univ Wisconsin Madison, Sch Nursing, Madison, WI USA.
   [Hagen, Erika W. W.; Barnet, Jodi H. H.; Peppard, Paul E. E.] Univ Wisconsin Madison, Sch Med & Publ Hlth, Dept Populat Hlth Sci, Madison, WI USA.
   [Hale, Lauren] SUNY Stony Brook, Renaissance Sch Med, Dept Family Populat & Prevent Med, Stony Brook, NY USA.
   [Kuo, Wan-Chin] Univ Wisconsin Madison, Sch Nursing, R4121, Signe Skott Cooper Hall, 701 Highland Ave, Madison, WI 53705 USA.
C3 University of Wisconsin System; University of Wisconsin Madison;
   University of Wisconsin System; University of Wisconsin Madison; State
   University of New York (SUNY) System; Stony Brook University; Stony
   Brook University Hospital; University of Wisconsin System; University of
   Wisconsin Madison
RP Kuo, WC (corresponding author), Univ Wisconsin Madison, Sch Nursing, R4121, Signe Skott Cooper Hall, 701 Highland Ave, Madison, WI 53705 USA.
EM wkuo4@wisc.edu
RI Hale, Lauren/K-3227-2013; Kuo, Wan-chin/HHN-6428-2022
OI Kuo, Wan-chin/0000-0002-5658-6077
FU National Institutes of Health
FX NationalInstitutesof Health
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NR 70
TC 4
Z9 4
U1 1
U2 8
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1532-3005
EI 1532-2998
J9 STRESS HEALTH
JI Stress Health
PD AUG
PY 2023
VL 39
IS 3
BP 614
EP 626
DI 10.1002/smi.3210
EA DEC 2022
PG 13
WC Psychology, Applied; Psychiatry; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA O1SD9
UT WOS:000916166500001
PM 36413205
OA hybrid
DA 2025-06-11
ER

PT J
AU Kendall-Tackett, K
AF Kendall-Tackett, Kathleen
TI Long-Chain Omega-3 Fatty Acids and Women's Mental Health in the
   Perinatal Period and Beyond
SO JOURNAL OF MIDWIFERY & WOMENS HEALTH
LA English
DT Article
DE docosahexaenoic acid; eicosapentaenoic acid; inflammation; omega-3s;
   postpartum depression
ID ETHYL-EICOSAPENTAENOIC ACID; ESSENTIAL FATTY-ACIDS; DOUBLE-BLIND;
   POSTPARTUM DEPRESSION; DOCOSAHEXAENOIC ACID; SEAFOOD CONSUMPTION;
   FISH-OIL; SUPPLEMENTATION; PREGNANCY; SYMPTOMS
AB Recent research has shown that depression and a range of physical illnesses, including heart disease, metabolic syndrome, and type 2 diabetes, have an inflammatory etiology. The long-chain omega-3 fatty acids (omega-3s) eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), which are found in fish and fish-oil products, may protect against these illnesses, in part because they lower inflammation. This article reviews the recent research on omega-3s and women's mental health, with a particular focus on the perinatal period. These studies include population studies examining fish consumption and studies testing the efficacy of EPA and DHA as treatments for depression. Although the findings are mixed, the majority of studies indicate that EPA has efficacy in treating depression either alone or in combination with DHA and/or antidepressant medications. The role of DHA alone in mental health is less clear, but it is generally combined with EPA and appears to have a beneficial effect. In moderate doses, EPA and DHA appear safe for pregnant and postpartum women, and they are well tolerated by patients. J Midwifery Womens Health 2010; 55: 561-567 (C) 2010 by the American College of Nurse-Midwives.
C1 Texas Tech Univ, Dept Pediat, Sch Med, Amarillo, TX 79124 USA.
C3 Texas Tech University System; Texas Tech University
RP Kendall-Tackett, K (corresponding author), Texas Tech Univ, Dept Pediat, Sch Med, 2504 Sweetgum Ln, Amarillo, TX 79124 USA.
EM Kkendallt@aol.com
OI Kendall-Tackett, Kathleen/0000-0003-0709-1059
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NR 45
TC 20
Z9 23
U1 0
U2 17
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1526-9523
EI 1542-2011
J9 J MIDWIFERY WOM HEAL
JI J. Midwifery Women Health
PD NOV-DEC
PY 2010
VL 55
IS 6
BP 561
EP 567
DI 10.1016/j.jmwh.2010.02.014
PG 7
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA 670QB
UT WOS:000283441300011
PM 20974418
DA 2025-06-11
ER

PT J
AU Jawad, MY
   Meshkat, S
   Tabassum, A
   Mckenzie, A
   Di Vincenzo, JD
   Guo, Z
   Musavi, NB
   Phan, L
   Ceban, F
   Kwan, ATH
   Ramachandra, R
   Le, GH
   Mansur, RB
   Rosenblat, JD
   Ho, R
   Rhee, TG
   McIntyre, RS
AF Jawad, Muhammad Youshay
   Meshkat, Shakila
   Tabassum, Aniqa
   Mckenzie, Andrea
   Di Vincenzo, Joshua D.
   Guo, Ziji
   Musavi, Nabiha Batool
   Phan, Lee
   Ceban, Felicia
   Kwan, Angela T. H.
   Ramachandra, Ranuk
   Le, Gia Han
   Mansur, Rodrigo B.
   Rosenblat, Joshua D.
   Ho, Roger
   Rhee, Taeho Greg
   McIntyre, Roger S.
TI The bidirectional association of nonalcoholic fatty liver disease with
   depression, bipolar disorder, and schizophrenia
SO CNS SPECTRUMS
LA English
DT Review
DE Depression; Bipolar disorder; Mood Disorders; Schizophrenia; NAFLD;
   NASH; Fatty Liver; Metabolic Syndrome; Inflammation; insulin resistance
ID INSULIN-RESISTANCE; CORTISOL SECRETION; IMMUNE-SYSTEM; RISK-FACTORS;
   WEIGHT-GAIN; EARLY-LIFE; INFLAMMATION; PREVALENCE; POPULATION; ANXIETY
AB Nonalcoholic fatty liver disease (NAFLD) is a complex metabolic-inflammatory disease associated with poor outcomes and decreased quality of life. NAFLD is overrepresented in patients with psychiatric disorders like depression, bipolar disorder, and schizophrenia; however, a comprehensive review on NAFLD and psychiatric disorders remains to be delineated. This review endeavors to investigate the association of NAFLD with psychiatric disorders, including shared pathogenesis and future clinical derivatives. Extant literature suggests that patients with psychiatric disorders (in particular, mood disorders) are more susceptible to the development of NAFLD due to multiple reasons, including but not limited to hypothalamic-pituitary-adrenal axis dysregulation, metabolic syndrome, and chronic perceived stress. Moreover, the clinical manifestations of mood disorders (e.g., anhedonia, psychomotor retardation, lifestyle modification, etc.), and potentially long-term treatment with weight-gaining agents, differentially affect these patients, making them more prone to NAFLD. Considering the increased morbidity associated with both mood disorders and NAFLD, our review recommends regular screenings for NAFLD in select patients with mood disorders exhibiting signs of increased risk (i.e., obesity, metabolic syndrome, diabetes, or family history of NAFLD) for better diagnosis and holistic care of both potentially interrelated conditions.
C1 [Jawad, Muhammad Youshay; Meshkat, Shakila; Tabassum, Aniqa; Mckenzie, Andrea; Di Vincenzo, Joshua D.; Phan, Lee; Ceban, Felicia; Kwan, Angela T. H.; Ramachandra, Ranuk; Le, Gia Han; Mansur, Rodrigo B.; Rosenblat, Joshua D.; McIntyre, Roger S.] Univ Hlth Network, Mood Disorders Psychopharmacol Unit, Toronto, ON, Canada.
   [Jawad, Muhammad Youshay; Guo, Ziji; Ceban, Felicia; Kwan, Angela T. H.; Ramachandra, Ranuk; Le, Gia Han; McIntyre, Roger S.] Brain & Cognit Discovery Fdn, Toronto, ON, Canada.
   [Musavi, Nabiha Batool] Liaquat Natl Med Coll, Karachi, Pakistan.
   [Kwan, Angela T. H.] Univ Ottawa, Fac Med, Ottawa, ON, Canada.
   [Mansur, Rodrigo B.; Rosenblat, Joshua D.; McIntyre, Roger S.] Univ Toronto, Dept Psychiat, Toronto, ON, Canada.
   [Ho, Roger] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Psychol Med, Singapore, Singapore.
   [Ho, Roger] Natl Univ Singapore, Inst Hlth Innovat & Technol iHealthtech, Singapore, Singapore.
   [Rhee, Taeho Greg] Yale Univ, Sch Med, Dept Psychiat, New Haven, CT USA.
   [Rhee, Taeho Greg] VA Connecticut Healthcare Syst, VA New England Mental Illness Res Educ & Clin Ctr, West Haven, CT USA.
   [Rhee, Taeho Greg] Univ Connecticut, Sch Med, Dept Publ Hlth Sci, Farmington, CT USA.
   [McIntyre, Roger S.] Univ Toronto, Dept Pharmacol & Toxicol, Toronto, ON, Canada.
C3 University of Toronto; University Health Network Toronto; University of
   Ottawa; University of Toronto; National University of Singapore;
   National University of Singapore; Yale University; US Department of
   Veterans Affairs; Veterans Health Administration (VHA); VA Connecticut
   Healthcare System; University of Connecticut; University of Toronto
RP McIntyre, RS (corresponding author), Univ Hlth Network, Mood Disorders Psychopharmacol Unit, Toronto, ON, Canada.; McIntyre, RS (corresponding author), Brain & Cognit Discovery Fdn, Toronto, ON, Canada.; McIntyre, RS (corresponding author), Univ Toronto, Dept Psychiat, Toronto, ON, Canada.; McIntyre, RS (corresponding author), Univ Toronto, Dept Pharmacol & Toxicol, Toronto, ON, Canada.
EM roger.mcintyre@bcdf.org
RI McIntyre, Roger/AAU-1000-2020; Di Vincenzo, Joshua/HHS-7099-2022; Kwan,
   Angela/AAX-7569-2021; Mansur, Rodrigo/N-7131-2019; Lê, Gia
   Hân/JGM-8718-2023; Meshkat, Shakila/HHZ-1030-2022; Rhee, Taeho
   Greg/HIZ-6892-2022; Ho, Roger/ABD-9061-2021
OI Tabassum, Aniqa/0000-0003-2928-6711; Kwan, Angela
   T.H./0000-0003-4013-1112; Ramachandra, Ranuk/0000-0002-2542-9802
FU Canadian Institutes of Health Research (CIHR); Physicians' Services
   Incorporated (PSI) Foundation; Baszucki Brain Research Fund; Department
   of Psychiatry, University of Toronto; American Psychiatric Association;
   American Society of Psychopharmacology; Canadian Cancer Society;
   Canadian Psychiatric Association; Joseph M. West Family Memorial Fund;
   Timeposters Fellowship; University Health Network Centre for Mental
   Health; University of Toronto; National Institute on Aging (NIA) through
   Yale School of Medicine [T32AG0191]; NIA; National Institute of Mental
   Health [R21MH117438, R21AG070666]; Institute for Collaboration on
   Health, Intervention, and Policy (InCHIP) of the University of
   Connecticut; CIHR/GACD/National Natural Science Foundation of China
   (NSFC); Milken Institute
FX R.B.M. has received research grant support from the Canadian Institutes
   of Health Research (CIHR), the Physicians' Services Incorporated (PSI)
   Foundation and the Baszucki Brain Research Fund; and support from an
   Academic Scholars Award from the Department of Psychiatry, University of
   Toronto. J.D.R. is the medical director of the Braxia Health (formally
   known as the Canadian Rapid Treatment Center of Excellence and is a
   fully owned subsidiary of Braxia Scientific Corp) which provides
   ketamine and esketamine treatment for depression; he has received
   research grant support from the American Psychiatric Association, the
   American Society of Psychopharmacology, the Canadian Cancer Society, the
   Canadian Psychiatric Association, the Joseph M. West Family Memorial
   Fund, the Timeposters Fellowship, the University Health Network Centre
   for Mental Health, and the University of Toronto and speaking,
   consultation, or research fees from Allergan, COMPASS, Janssen,
   Lundbeck, and Sunovion. was supported in part by the National Institute
   on Aging (NIA) through Yale School of Medicine (#T32AG019134) in the
   past 3 years. T.G.R. has also been funded by the NIA and National
   Institute of Mental Health (#R21MH117438 and R21AG070666) and Institute
   for Collaboration on Health, Intervention, and Policy (InCHIP) of the
   University of Connecticut. R.M. has received research grant support from
   CIHR/GACD/National Natural Science Foundation of China (NSFC) and the
   Milken Institute; speaker/consultation fees from Lundbeck, Janssen,
   Alkermes, Neumora Therapeutics, Boehringer Ingelheim, Sage, Biogen,
   Mitsubishi Tanabe, Purdue, Pfizer, Otsuka, Takeda, Neurocrine, Sunovion,
   Bausch Health, Axsome, Novo Nordisk, Kris, Sanofi, Eisai,
   Intra-Cellular, NewBridge Pharmaceuticals,Viatris, Abbvie, Atai Life
   Sciences. Dr. Roger McIntyre is a CEO of Braxia Scientific Corp.
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NR 103
TC 21
Z9 22
U1 1
U2 15
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 1092-8529
EI 2165-6509
J9 CNS SPECTRUMS
JI CNS Spectr.
PD OCT
PY 2023
VL 28
IS 5
BP 541
EP 560
AR PII S1092852922001043
DI 10.1017/S1092852922001043
EA OCT 2022
PG 20
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Psychiatry
GA U5HX1
UT WOS:000889873300001
PM 36268655
DA 2025-06-11
ER

PT J
AU Després, JP
AF Despres, Jean-Pierre
TI Pleiotropic Effects of Rimonabant: Clinical Implications
SO CURRENT PHARMACEUTICAL DESIGN
LA English
DT Review
DE Abdominal obesity; cardiometabolic risk; cardiovascular disease;
   endocannabinoid system; intra-abdominal adiposity; obesity; rimonabant;
   type 2 diabetes
ID CORONARY-HEART-DISEASE; CARDIOMETABOLIC RISK-FACTORS;
   HYPERTRIGLYCERIDEMIC WAIST PHENOTYPE; MOLECULAR-WEIGHT ADIPONECTIN; CB1
   RECEPTOR ANTAGONIST; C-REACTIVE PROTEIN; BODY-MASS INDEX; ATHEROGENIC
   METABOLIC TRIAD; ADIPOSE-TISSUE ACCUMULATION; IMPAIRED FASTING GLUCOSE
AB Abdominal obesity (high waist circumference) is more strongly associated with cardiovascular disease and type 2 diabetes than generalized adiposity (high body mass index). Recent research has highlighted the role of chronic overactivation of the endogenous endocannabinoid system, acting through its CB1 receptor, as a key factor involved in the development of abdominal obesity and related cardiometabolic risk abnormalities such as insulin resistance, low HDL-cholesterol, hypertriglyceridemia, inflammation and low adiponectin. Evidence suggests that these cardiometabolic risk factors/markers are not optimally managed by current treatments. Improving the nutrition and physical activity/exercise habits of patients remains the cornerstone of management of elevated global cardiometabolic risk. Antagonism of the endocannabinoid system provides a novel strategy to target several unaddressed cardiometabolic risk markers/factors. Randomized trials of rimonabant in patients with overweight or obesity and/or type 2 diabetes have demonstrated marked and significant improvements in body weight, waist circumference, glycemic control (in patients with type 2 diabetes), features of atherogenic dyslipidemia, insulin resistance, adipose tissue-derived cytokines (leptin and adiponectin) and C-reactive protein (a marker of systemic inflammation). Further analyses suggested that about half of the improvements of several cardiometabolic risk markers were independent from concomitant weight loss. Blood pressure also improved with rimonabant treatment, this effect being consistent with the blood pressure lowering effect of weight loss. The tolerability and safety of rimonabant have been extensively studied and most transient side effects include some gastrointestinal side effects, anxiety, mood changes and incidence of depressive disorders, particularly in patients with previous history of depression. Rimonabant is a useful option for patients with abdominal obesity and with related cardiometabolic risk abnormalities such as an atherogenic dyslipidemia and/or type 2 diabetes.
C1 [Despres, Jean-Pierre] Hop Laval, Res Ctr, Quebec Heart Inst, Quebec City, PQ G1V 4G5, Canada.
   [Despres, Jean-Pierre] Univ Laval, Dept Social & Prevent Med, Div Kinesiol, Quebec City, PQ, Canada.
C3 Laval University; Laval University Hospital; Laval University
RP Després, JP (corresponding author), Hop Laval, Res Ctr, Quebec Heart Inst, 2725 Chemin Ste Foy,Pavil Marguerite DYouville,4t, Quebec City, PQ G1V 4G5, Canada.
EM Jean-Pierre.Despres@crhl.ulaval.ca
FU Canadian Institutes of Health Research; Canadian Diabetes Association;
   Heart and Stroke Foundation; Foundation of the Quebec Heart Institute;
   Sanofi aventis
FX The work of the author has been supported by research grants from the
   Canadian Institutes of Health Research, the Canadian Diabetes
   Association, the Heart and Stroke Foundation and by the Foundation of
   the Quebec Heart Institute. Dr. Despres is the Scientific Director of
   the International Chair on Cardiometabolic Risk, which is supported by
   an unrestricted grant from Sanofi aventis awarded to Universite Laval.
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NR 155
TC 25
Z9 28
U1 0
U2 2
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1381-6128
EI 1873-4286
J9 CURR PHARM DESIGN
JI Curr. Pharm. Design
PD FEB
PY 2009
VL 15
IS 5
BP 553
EP 570
DI 10.2174/138161209787315666
PG 18
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 415VG
UT WOS:000263963600008
PM 19199981
DA 2025-06-11
ER

PT J
AU Li, HX
   George, DM
   Jaarsma, RL
   Mao, XZ
AF Li, Hongxing
   George, Daniel M.
   Jaarsma, Ruurd L.
   Mao, Xinzhan
TI Metabolic syndrome and components exacerbate osteoarthritis symptoms of
   pain, depression and reduced knee function
SO ANNALS OF TRANSLATIONAL MEDICINE
LA English
DT Article
DE Hyperglycemia; hypertension; metabolic syndrome X; obesity;
   osteoarthritis
ID DEPENDENT DIABETES-MELLITUS; PREVALENCE; OBESITY; HAND; EPIDEMIOLOGY;
   PATHOGENESIS; ASSOCIATION; POPULATION; PREDICTOR; CARTILAGE
AB Background: The purpose of this study was to investigate the prevalence of metabolic syndrome and its co-morbidities in patients with primary knee osteoarthritis and to assess if the severity of metabolic syndrome, and components, correlates with the severity of osteoarthritis symptoms.
   Methods: A case controlled analysis of 70 patients with osteoarthritis compared to a control group of 81 patients. Each patient underwent clinical review including history, examination, and pathology tests. The case-group all had stage IV osteoarthritis as determined by radiographs and intra-operative assessment. In addition a visual analogue scale (VAS), Hospital for Special Surgery knee score (HSS), and Hamilton Depression scores were completed.
   Results: The prevalence of hypertension, obesity, dyslipidemia and metabolic syndrome was significantly higher in the patients with osteoarthritis compared to the control group. There is a significant correlation between the degree of hypertension, the presence of dyslipidemia or hyperglycemia and the severity of osteoarthritis symptoms. Variables hypertension, low HDL-C levels, and the number of co-morbidities were all identified as risk factors for increased osteoarthritis symptoms.
   Conclusions: There is a correlation between the number of metabolic disorders, the severity of hypertension and severity of osteoarthritis symptoms. Hypertension and decreased HDL-cholesterol were positive risk factors for increased osteoarthritis symptomatology.
C1 [Li, Hongxing] Cent Hosp Shaoyang, Dept Orthopaed Surg, Shaoyang 422000, Peoples R China.
   [George, Daniel M.; Jaarsma, Ruurd L.] Flinders Univ S Australia, Sch Med, Dept Orthopaed, Adelaide, SA, Australia.
   [George, Daniel M.; Jaarsma, Ruurd L.] Flinders Med Ctr, Dept Orthopaed & Trauma, Adelaide, SA, Australia.
   [Mao, Xinzhan] 2nd Xiangya Hosp, Dept Orthopaed Surg, Level 16,139 Peoples Rd, Changsha 410011, Hunan, Peoples R China.
C3 Flinders University South Australia; Flinders Medical Centre
RP Mao, XZ (corresponding author), 2nd Xiangya Hosp, Dept Orthopaed Surg, Level 16,139 Peoples Rd, Changsha 410011, Hunan, Peoples R China.
EM MaoXinzhan72@126.com
OI Jaarsma, Ruurd/0000-0003-4308-7815; George, Daniel/0000-0002-1853-2983
FU National Natural Science Foundation of China [81371997]
FX Professor Mao now receives funding from the National Natural Science
   Foundation of China (81371997) for future research into osteoarthritis
   and its treatment.
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NR 46
TC 69
Z9 75
U1 0
U2 22
PU AME PUBLISHING COMPANY
PI SHATIN
PA FLAT-RM C 16F, KINGS WING PLAZA 1, NO 3 KWAN ST, SHATIN, HONG KONG
   00000, PEOPLES R CHINA
SN 2305-5839
EI 2305-5847
J9 ANN TRANSL MED
JI ANN. TRANSL. MED.
PD APR
PY 2016
VL 4
IS 7
AR 133
DI 10.21037/atm.2016.03.48
PG 10
WC Oncology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Research & Experimental Medicine
GA DY0NA
UT WOS:000384792300008
PM 27162783
OA Green Published
DA 2025-06-11
ER

PT J
AU Rioli, G
   Tassi, S
   Mattei, G
   Ferrari, S
   Galeazzi, GM
   Mancini, S
   Alboni, S
   Roncucci, L
AF Rioli, Giulia
   Tassi, Silvia
   Mattei, Giorgio
   Ferrari, Silvia
   Galeazzi, Gian Maria
   Mancini, Stefano
   Alboni, Silvia
   Roncucci, Luca
TI The Association Between Symptoms of Anxiety, Depression, and
   Cardiovascular Risk Factors Results From an Italian Cross-Sectional
   Study
SO JOURNAL OF NERVOUS AND MENTAL DISEASE
LA English
DT Article
DE Anxiety; biopsychosocial complexity; cardiovascular risk factors;
   depression; inflammation
ID INTIMA-MEDIA THICKNESS; CORONARY-HEART-DISEASE; HOSPITAL ANXIETY;
   METABOLIC SYNDROME; MENTAL-DISORDERS; HEALTH SURVEY; PREVALENCE; CARE;
   VALIDITY; ADULTS
AB Cardiovascular diseases, anxiety, and depression are among the most frequent clinical conditions in the Western world, often in comorbidity. Evidence regarding a shared pathophysiology suggests a mediating role by chronic systemic inflammation. The aims of this study were to measure the association between anxiety and depressive symptoms, cardiovascular risk factors, and inflammatory markers. Outpatients aged 40 years or more undergoing colonoscopy after positive fecal occult blood test were enrolled; the following data were collected: body mass index, blood pressure, blood glucose, lipid profile, C-reactive protein (CRP) level, carotid thickness, Hospital Anxiety and Depression Scale, Temperament and Character Inventory, INTERdisciplinary MEDicine Self-Assessment, and 36-Item Short-Form Health Survey scores. Fifty-four patients were enrolled; 30.2% had anxiety symptoms, 18.9% depressive symptoms, and 9.4% concomitant anxiety-depressive symptoms. Anxiety symptoms were associated with low high-density lipoprotein levels. Depressive symptoms were associated with CRP levels, providing supporting evidence for the role of inflammation in the pathophysiology of depression.
C1 [Rioli, Giulia; Tassi, Silvia; Mattei, Giorgio; Ferrari, Silvia; Galeazzi, Gian Maria] Univ Modena & Reggio Emilia, Dept Biomed Metab & Neural Sci, Modena, Italy.
   [Rioli, Giulia] Univ Modena & Reggio Emilia, Dept Biomed Metab & Neural Sci, PhD Program Clin & Expt Med, Modena, Italy.
   [Mattei, Giorgio] Univ Modena & Reggio Emilia, Dept Econ, PhD Program Labour Dev & Innovat, Modena, Italy.
   [Mattei, Giorgio] Marco Biagi Fdn, Modena, Italy.
   [Mattei, Giorgio] Assoc Res Psychiat, Modena, Italy.
   [Ferrari, Silvia; Galeazzi, Gian Maria] Univ Modena & Reggio Emilia, Ctr Neurosci & Neurotechnol, Modena, Italy.
   [Mancini, Stefano; Roncucci, Luca] Univ Modena & Reggio Emilia, Dept Med & Surg Sci, Modena, Italy.
   [Alboni, Silvia] Univ Modena & Reggio Emilia, Dept Life Sci, Modena, Italy.
C3 Universita di Modena e Reggio Emilia; Universita di Modena e Reggio
   Emilia; Universita di Modena e Reggio Emilia; Universita di Modena e
   Reggio Emilia; Universita di Modena e Reggio Emilia; Universita di
   Modena e Reggio Emilia
RP Rioli, G (corresponding author), Univ Modena & Reggio Emilia, Policlin Modena, Clin Psichiat, Via Pozzo 71, I-41124 Modena, Italy.
EM giulyrioli@hotmail.it
RI Ferrari, Silvia/G-5964-2011; Alboni, Silvia/HME-1742-2023; Roncucci,
   Luca/L-1392-2016; Galeazzi, Gian/J-6676-2016; Mancini,
   Stefano/B-1190-2016
OI Galeazzi, Gian/0000-0003-2706-3362; Mancini, Stefano/0000-0002-7350-5603
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NR 56
TC 9
Z9 9
U1 0
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0022-3018
EI 1539-736X
J9 J NERV MENT DIS
JI J. Nerv. Ment. Dis.
PD MAY
PY 2019
VL 207
IS 5
BP 340
EP 347
DI 10.1097/NMD.0000000000000969
PG 8
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA HV4HR
UT WOS:000465947900005
PM 30958417
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Lucini, D
   Zanuso, S
   Solaro, N
   Vigo, C
   Malacarne, M
   Pagani, M
AF Lucini, Daniela
   Zanuso, Silvano
   Solaro, Nadia
   Vigo, Chiara
   Malacarne, Mara
   Pagani, Massimo
TI Reducing the risk of metabolic syndrome at the worksite: preliminary
   experience with an ecological approach
SO ACTA DIABETOLOGICA
LA English
DT Article
DE Metabolic syndrome; Prevention; Exercise medicine; Workplace; Lifestyle
ID WORKPLACE HEALTH-PROMOTION; LIFE-STYLE; CARDIOVASCULAR HEALTH;
   SCIENTIFIC STATEMENT; WELLNESS PROGRAMS; PHYSICAL-ACTIVITY; ASSOCIATION;
   PREVENTION; DISEASE; STRESS
AB Given the time spent at work, the workplace represents an ideal setting to implement preventive programs for non-communicable diseases, the major cause of mortality and morbidity in Western and developing countries. We sought to verify if an ecological approach based on corporate culture, employees' education and concrete modifications of workplace environment, offering easy opportunity to assume healthy lifestyle, could be associated with reduced cardiometabolic risk.
   The study involved 1089 workers in two multinational companies following different workplace health promotion policies. Company A offered to all employees the opportunity to access a web platform dedicated to general information on health and diseases. Company B implemented an ecological model encompassing company culture, employees' education and concrete modifications of workplace environment, giving to all employees the opportunity to adopt healthy solutions throughout daily living at workplace. Participants volunteered self-reported clinical information using an IT tool. Numbers of Metabolic Syndrome components (MetS) were taken as proxy of cardiometabolic risk.
   MetS probability obtained via statistical modeling was lower in company B as compared to company A, and absenteeism was also lower in company B. Our study shows that a work environment favoring assumption of healthy lifestyle, as in company B, is associated with a lower percentage of employees with MetS components and lower absenteeism. Moreover, statistical modeling shows that individual probabilities of being without MetS elements, controlling for age and gender, is remarkably higher in company B.
   Our data suggest that ecological approaches might be useful in worksite prevention policies.
C1 [Lucini, Daniela; Vigo, Chiara; Malacarne, Mara; Pagani, Massimo] Univ Milan, BIOMETRA, Milan, Italy.
   [Lucini, Daniela; Vigo, Chiara; Malacarne, Mara] Humanitas Clin & Res Ctr, Sez Med Esercizio & Patol Funz, Via Alessandro Manzoni 56, I-20089 Milan, Italy.
   [Zanuso, Silvano] Univ Greenwich, London SE18 6PF, England.
   [Zanuso, Silvano] Technogym Sci Dept, Cesena, Italy.
   [Solaro, Nadia] Univ Milano Bicocca, Dept Stat & Quantitat Methods, Milan, Italy.
C3 University of Milan; University of Greenwich; University of
   Milano-Bicocca
RP Lucini, D (corresponding author), Univ Milan, BIOMETRA, Milan, Italy.; Lucini, D (corresponding author), Humanitas Clin & Res Ctr, Sez Med Esercizio & Patol Funz, Via Alessandro Manzoni 56, I-20089 Milan, Italy.
EM daniela.lucini@unimi.it
RI Lucini, Daniela/ABD-7517-2021
OI Lucini, Daniela/0000-0003-4845-8988; SOLARO, NADIA/0000-0001-8732-5737
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NR 43
TC 7
Z9 9
U1 0
U2 17
PU SPRINGER-VERLAG ITALIA SRL
PI MILAN
PA VIA DECEMBRIO, 28, MILAN, 20137, ITALY
SN 0940-5429
EI 1432-5233
J9 ACTA DIABETOL
JI Acta Diabetol.
PD FEB
PY 2016
VL 53
IS 1
BP 63
EP 71
DI 10.1007/s00592-015-0744-x
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA DD6MI
UT WOS:000370037900009
PM 25863782
DA 2025-06-11
ER

PT J
AU Lamers, F
   Vogelzangs, N
   Merikangas, KR
   de Jonge, P
   Beekman, ATF
   Penninx, BWJH
AF Lamers, F.
   Vogelzangs, N.
   Merikangas, K. R.
   de Jonge, P.
   Beekman, A. T. F.
   Penninx, B. W. J. H.
TI Evidence for a differential role of HPA-axis function, inflammation and
   metabolic syndrome in melancholic versus atypical depression
SO MOLECULAR PSYCHIATRY
LA English
DT Article
DE depression; inflammation; metabolic syndrome; salivary cortisol;
   subtypes
ID MAJOR DEPRESSION; SALIVARY CORTISOL; ANTIDEPRESSANT USE; ANXIETY;
   CYTOKINES; ASSOCIATIONS; NETHERLANDS; SYMPTOMS; SUBTYPES; MOOD
AB The hypothalamic-pituitary-adrenal (HPA) axis and the inflammatory response system have been suggested as pathophysiological mechanisms implicated in the etiology of major depressive disorder (MDD). Although meta-analyses do confirm associations between depression and these biological systems, effect sizes vary greatly among individual studies. A potentially important factor explaining variability is heterogeneity of MDD. Aim of this study was to evaluate the association between depressive subtypes (based on latent class analysis) and biological measures. Data from 776 persons from the Netherlands Study of Depression and Anxiety, including 111 chronic depressed persons with melancholic depression, 122 with atypical depression and 543 controls were analyzed. Inflammatory markers (C-reactive protein, interleukin-6, tumor necrosis factor-alpha), metabolic syndrome components, body mass index (BMI), saliva cortisol awakening curves (area under the curve with respect to the ground (AUCg) and with respect to the increase (AUCi)), and diurnal cortisol slope were compared among groups. Persons with melancholic depression had a higher AUCg and higher diurnal slope compared with persons with atypical depression and with controls. Persons with atypical depression had significantly higher levels of inflammatory markers, BMI, waist circumference and triglycerides, and lower high-density lipid cholesterol than persons with melancholic depression and controls. This study confirms that chronic forms of the two major subtypes of depression are associated with different biological correlates with inflammatory and metabolic dysregulation in atypical depression and HPA-axis hyperactivity in melancholic depression. The data provide further evidence that chronic forms of depressive subtypes differ not only in their symptom presentation, but also in their biological correlates. These findings have important implications for future research on pathophysiological pathways of depression and treatment.
C1 [Lamers, F.; Merikangas, K. R.] NIMH, Genet Epidemiol Res Branch, Intramural Res Program, NIH, Bethesda, MD 20892 USA.
   [Vogelzangs, N.; Beekman, A. T. F.; Penninx, B. W. J. H.] Vrije Univ Amsterdam Med Ctr, Dept Psychiat EMGO, Inst Hlth & Care Res, Amsterdam, Netherlands.
   [de Jonge, P.; Penninx, B. W. J. H.] Univ Groningen, Univ Med Ctr Groningen, ICPE, Dept Psychiat, Groningen, Netherlands.
   [de Jonge, P.; Penninx, B. W. J. H.] Univ Groningen, Univ Med Ctr Groningen, Dept Internal Med, Groningen, Netherlands.
   [Penninx, B. W. J. H.] Leiden Univ, Med Ctr, Dept Psychiat, Leiden, Netherlands.
C3 National Institutes of Health (NIH) - USA; NIH National Institute of
   Mental Health (NIMH); Vrije Universiteit Amsterdam; VU UNIVERSITY
   MEDICAL CENTER; University of Groningen; University of Groningen; Leiden
   University - Excl LUMC; Leiden University; Leiden University Medical
   Center (LUMC)
RP Lamers, F (corresponding author), NIMH, Genet Epidemiol Res Branch, Intramural Res Program, NIH, 35 Convent Dr,Room 1A108, Bethesda, MD 20892 USA.
EM lamersf@mail.nih.gov
RI Beekman, Aartjan T./LUZ-6919-2024; Lamers, Femke/G-5161-2012; Penninx,
   Brenda/S-7627-2017; de Jonge, Peter/L-6395-2013
OI Lamers, Femke/0000-0003-4344-5766; de Jonge, Peter/0000-0002-0866-6929;
   Merikangas, Kathkeen/0000-0002-4667-2414
FU Geestkracht program of the Netherlands Organisation for Health Research
   and Development (Zon-Mw) [10-000-1002]; VU University Medical Center;
   GGZ inGeest; Arkin; Leiden University Medical Center; GGZ Rivierduinen;
   University Medical Center Groningen; Lentis; GGZ Friesland; GGZ Drenthe;
   Scientific Institute for Quality of Healthcare (IQ healthcare);
   Netherlands Institute for Health Services Research (NIVEL); Netherlands
   Institute of Mental Health and Addiction (Trimbos); Neuroscience Campus
   Amsterdam; Netherlands Organisation for Scientific research (VIDI
   project); Rubicon fellowship from the Netherlands Organisation for
   Scientific research; National Institute of Mental Health, Genetic
   Epidemiology Research Branch; VICI grant from the Netherlands
   Organisation for Scientific research
FX The infrastructure for the NESDA study (www.nesda.nl) is funded through
   the Geestkracht program of the Netherlands Organisation for Health
   Research and Development (Zon-Mw, grant number 10-000-1002) and is
   supported by participating universities and mental health care
   organizations (VU University Medical Center, GGZ inGeest, Arkin, Leiden
   University Medical Center, GGZ Rivierduinen, University Medical Center
   Groningen, Lentis, GGZ Friesland, GGZ Drenthe, Scientific Institute for
   Quality of Healthcare (IQ healthcare), Netherlands Institute for Health
   Services Research (NIVEL) and Netherlands Institute of Mental Health and
   Addiction (Trimbos). Biomarker funding was provided by the Neuroscience
   Campus Amsterdam and the Netherlands Organisation for Scientific
   research (VIDI project). BWJHP is supported by a VICI grant from the
   Netherlands Organisation for Scientific research. FL is supported by a
   Rubicon fellowship from the Netherlands Organisation for Scientific
   research and by a Supplemental Intramural Research Training Award from
   the National Institute of Mental Health, Genetic Epidemiology Research
   Branch. The views and opinions expressed in this article are ours and
   should not be construed to represent the views of any of the sponsoring
   organizations, agencies or US Government.
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NR 65
TC 530
Z9 580
U1 1
U2 146
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1359-4184
EI 1476-5578
J9 MOL PSYCHIATR
JI Mol. Psychiatr.
PD JUN
PY 2013
VL 18
IS 6
BP 692
EP 699
DI 10.1038/mp.2012.144
PG 8
WC Biochemistry & Molecular Biology; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Neurosciences & Neurology; Psychiatry
GA 151HP
UT WOS:000319451600011
PM 23089630
DA 2025-06-11
ER

PT J
AU Sasváriová, M
   Salvaras, L
   Seckárová Micháliková, D
   Tyukos Kaprinay, B
   Knezl, V
   Gáspárová, Z
   Stankovicová, T
AF Sasvariova, Michaela
   Salvaras, Lazaros
   Seckarova Michalikova, Dominika
   Tyukos Kaprinay, Barbara
   Knezl, Vladimir
   Gasparova, Zdenka
   Stankovicova, Tatiana
TI Assessment of the Cardiovascular Risk of High-Fat-High-Fructose Diet in
   Hereditary Hypertriacylglycerolemic Rats and Venlafaxine Effect
SO PHYSIOLOGICAL RESEARCH
LA English
DT Article
DE Metabolic syndrome; Venlafaxine; ECG; Cardiac contraction;
   Ischemia/Reperfusion
ID METABOLIC SYNDROME; EXPRESSION; MYOSIN; HEAVY; MODEL; PGC-1-ALPHA;
   PREVALENCE; RECEPTOR; DISEASE; STRESS
AB Metabolic syndrome (MetS) represents a worldwide health problem, affecting cardiovascular and mental health. People with MetS are often suffering from depression. We used hereditary hypertriacylglycerolemic (HTG) rats as an animal model of MetS, and these were fed a high-fat-high-fructose diet (HFFD) to imitate unhealthy eating habits of people having several MetS risk factors and suffering depression. Male HTG rats were fed a standard diet (HTG-SD) or HFFD for eight weeks (HFFD8). Venlafaxine was administered for the last three weeks of the experiment (HFFD8+VE). Heart function was observed on the level of intact organisms (standard ECG in vivo), isolated hearts (perfusion according to Langendorff ex vivo), and molecular level, using the RT-PCR technique. The function of the isolated perfused heart was monitored under baseline and ischemia/reperfusion conditions. Analysis of ECG showed electrical abnormalities in vivo, such significant QRS complex prolongation and increased heart rate. vivo venlafaxine significantly reduced QT interval after ischemia/reperfusion injury. Baseline values of contractile abilities of the heart tended to be suppressed by HFFD. A significant reduction of LVDP was present in the HFFD8 group. Molecular analysis of specific genes involved in cardiac electrical (Cacna1c, Scn5a), contractile (Myh6, Myh7), metabolic function (Pgc1 alpha) and calcium handling (Serca2a, Ryr2) supported some of the functional findings in vivo and ex vivo. Based on the present effect venlafaxine on heart function, further research is needed regarding its cardiometabolic safety in the treatment of patients with MetS suffering from depression.
C1 [Sasvariova, Michaela; Salvaras, Lazaros; Stankovicova, Tatiana] Comenius Univ, Fac Pharm, Dept Pharmacol & Toxicol, Odbojarov 10, Bratislava 83232, Slovakia.
   [Seckarova Michalikova, Dominika; Tyukos Kaprinay, Barbara; Knezl, Vladimir; Gasparova, Zdenka] Slovak Acad Sci, Ctr Expt Med, Inst Expt Pharmacol & Toxicol, Bratislava, Slovakia.
C3 Comenius University Bratislava; Slovak Academy of Sciences; Institute of
   Experimental Pharmacology & Toxicology, SAS; Centre of Experimental
   Medicine, SAS
RP Stankovicová, T (corresponding author), Comenius Univ, Fac Pharm, Dept Pharmacol & Toxicol, Odbojarov 10, Bratislava 83232, Slovakia.
EM stankovicova@fpharm.uniba.sk
FU Slovak Republic [VEGA 2/0018/23, APVV-22-0541, APVV-19-0435]
FX This work was supported by the Scientific Grant Agency of the Ministry
   of Education, Science, Research and Sportthe Slovak Republic VEGA
   2/0018/23, APVV-22-0541, and APVV-19-0435.r the Slovak Republic VEGA
   2/0018/23, APVV-22-0541, and APVV-19-0435.
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NR 41
TC 1
Z9 1
U1 0
U2 0
PU ACAD SCIENCES CZECH REPUBLIC, INST PHYSIOLOGY
PI PRAGUE 4
PA VIDENSKA 1083, PRAGUE 4 142 20, CZECH REPUBLIC
SN 0862-8408
EI 1802-9973
J9 PHYSIOL RES
JI Physiol. Res.
PD DEC
PY 2024
VL 73
IS 6
BP 973
EP 984
DI 10.33549/physiolres.935420
PG 12
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA Y0V9A
UT WOS:001429422800007
PM 39903888
OA gold
DA 2025-06-11
ER

PT J
AU Virtanen, M
   Ferrie, JE
   Akbaraly, T
   Tabak, A
   Jokela, M
   Ebmeier, KP
   Singh-Manoux, A
   Kivimäki, M
AF Virtanen, Marianna
   Ferrie, Jane E.
   Akbaraly, Tasnime
   Tabak, Adam
   Jokela, Markus
   Ebmeier, Klaus P.
   Singh-Manoux, Archana
   Kivimaki, Mika
TI Metabolic Syndrome and Symptom Resolution in Depression: A 5-Year
   Follow-Up of Older Adults
SO JOURNAL OF CLINICAL PSYCHIATRY
LA English
DT Article
ID WHITEHALL-II; ANXIETY DISORDERS; HDL-CHOLESTEROL; LATER LIFE; COHORT;
   RISK; METAANALYSIS; ASSOCIATION; PREVALENCE; DISEASE
AB Objective: Although metabolic syndrome is associated with the incidence of depression, little is known about its contribution to the course of depression. We examined whether metabolic syndrome and its components are associated with long-term symptom resolution in older adults with depressive symptoms.
   Methods: Data from 965 participants in the Whitehall II cohort study (mean age = 62 years at baseline) were used to generate 1,172 person-observations of metabolic syndrome and its components (abdominal obesity, low level of high-density lipoprotein [HDL] cholesterol, high level of triglycerides, hypertension, and elevated fasting glucose or diabetes). All participants were depression cases at the beginning of 2 consecutive follow-up cycles: from 2002-2004 to 2007-2009 and from 2007-2009 to 2012-2013 (mean follow-up = 4.6 years). Depressive symptoms were assessed using the Center for Epidemiologic Studies Depression scale caseness at the beginning and the end of the 2 cycles.
   Results: In multivariable adjusted analyses, metabolic syndrome per se was not associated with symptom resolution. Of its components, low HDL cholesterol (risk ratio [RR] = 0.82; 95% CI, 0.68-1.00; P = .045) and high triglyceride levels (RR = 0.81; 95% CI, 0.70-0.95; P = .007) were associated with a lower likelihood of symptom resolution. These findings were replicated in a subpopulation without coronary heart disease and stroke (RR = 0.77 [95% CI, 0.63-0.95; P = .015] for low HDL cholesterol; RR = 0.79 [95% CI, 0.67-0.94; P = .006] for high triglycerides).
   Conclusions: Low HDL cholesterol and high triglyceride levels are associated with lower likelihood of long-term symptom resolution in depression. These data suggest that an adverse lipid profile, but not other components of metabolic syndrome, may delay recovery from depression.
C1 [Virtanen, Marianna] Finnish Inst Occupat Hlth, Topeliuksenkatu 41 A, Helsinki 00250, Finland.
   [Ferrie, Jane E.; Akbaraly, Tasnime; Tabak, Adam; Singh-Manoux, Archana; Kivimaki, Mika] UCL, Dept Epidemiol & Publ Hlth, London, England.
   [Ferrie, Jane E.] Univ Bristol, Sch Social & Community Med, Bristol, Avon, England.
   [Akbaraly, Tasnime] INSERM, U1198, Montpellier, France.
   [Akbaraly, Tasnime] Ecole Prat Hautes Etud, Paris, France.
   [Akbaraly, Tasnime] Univ Montpellier, Dept Mol Mech Neurodegenerat Dis, Montpellier, France.
   [Tabak, Adam] Semmelweis Univ, Fac Med, Dept Med 1, Budapest, Hungary.
   [Jokela, Markus] Univ Helsinki, Inst Behav Sci, Helsinki, Finland.
   [Ebmeier, Klaus P.] Univ Oxford, Warneford Hosp, Dept Psychiat, Oxford, England.
   [Singh-Manoux, Archana] AP HP, INSERM, U1018, Villejuif, France.
   [Kivimaki, Mika] Univ Helsinki, Fac Med, Dept Publ Hlth, Helsinki, Finland.
C3 Finnish Institute of Occupational Health; University of London;
   University College London; University of Bristol; Institut National de
   la Sante et de la Recherche Medicale (Inserm); Universite de
   Montpellier; Universite PSL; Ecole Pratique des Hautes Etudes (EPHE);
   Universite de Montpellier; Semmelweis University; University of
   Helsinki; University of Oxford; Institut National de la Sante et de la
   Recherche Medicale (Inserm); Universite Paris Saclay; Assistance
   Publique Hopitaux Paris (APHP); Hopital Universitaire Paul-Brousse -
   APHP; University of Helsinki
RP Virtanen, M (corresponding author), Finnish Inst Occupat Hlth, Topeliuksenkatu 41 A, Helsinki 00250, Finland.
EM marianna.virtanen@ttl.fi
RI Tabak, Adam/A-5007-2012; Kivimaki, Mika/B-3607-2012; Ebmeier,
   Klaus/B-4789-2008; Ferrie, Jane/AAZ-2009-2020; Akbaraly,
   Tasnime/H-1389-2018; Jokela, Markus/A-4669-2009; Singh-Manoux,
   Archana/F-6804-2013
OI Tabak, Adam/0000-0002-6234-3936; Akbaraly, Tasnime/0000-0002-2150-4190;
   Jokela, Markus/0000-0003-0117-0012; Kivimaki, Mika/0000-0002-4699-5627;
   Singh-Manoux, Archana/0000-0002-1244-5037; Ebmeier, Klaus
   P./0000-0002-5190-7038
FU Medical Research Council [K013351]; British Heart Foundation; National
   Heart, Lung, and Blood Institute, National Institutes of Health (NIH)
   [R01HL036310]; National Institute of Aging, NIH [R01AG013196,
   R01AG034454]; Academy of Finland [258598, 292824, G1001354]; National
   Heart, Lung, and Blood Institute [R01HL036310]; NIH [R01HL036310,
   R01AG034454]; NordForsk [75021]; Economic and Social Research Council;
   ESRC [ES/J023299/1] Funding Source: UKRI; MRC [G1001354, MR/K013351/1]
   Funding Source: UKRI
FX The Whitehall II Study is supported by grants from the Medical Research
   Council (K013351); British Heart Foundation; National Heart, Lung, and
   Blood Institute, National Institutes of Health (NIH) (R01HL036310); and
   the National Institute of Aging, NIH (R01AG013196 and R01AG034454). Dr
   Virtanen is supported by the Academy of Finland (258598, 292824). Dr
   Ebmeier is supported by the Medical Research Council (G1001354), Dr
   Akbaraly by the National Heart, Lung, and Blood Institute (R01HL036310),
   and Dr Singh-Manoux by the National Institute of Aging, NIH (R01AG013196
   and R01AG034454). Dr Kivimaki is supported by the Medical Research
   Council (K013351), the NIH (R01HL036310, R01AG034454), NordForsk
   (75021), and a professorial fellowship from the Economic and Social
   Research Council.
CR Akbaraly TN, 2011, DIABETES CARE, V34, P904, DOI 10.2337/dc10-1644
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   World Health Organization International Diabetes Foundation, 2006, INT DIAB FDN DEF DIA
NR 38
TC 27
Z9 30
U1 0
U2 9
PU PHYSICIANS POSTGRADUATE PRESS
PI MEMPHIS
PA P O BOX 752870, MEMPHIS, TN 38175-2870 USA
SN 0160-6689
EI 1555-2101
J9 J CLIN PSYCHIAT
JI J. Clin. Psychiatry
PD JAN
PY 2017
VL 78
IS 1
BP E1
EP E7
DI 10.4088/JCP.15m10399
PG 7
WC Psychology, Clinical; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA EN9OX
UT WOS:000396330600001
PM 28129497
DA 2025-06-11
ER

PT J
AU Berger, I
   Werdermann, M
   Bornstein, SR
   Steenblock, C
AF Berger, Ilona
   Werdermann, Martin
   Bornstein, Stefan R.
   Steenblock, Charlotte
TI The adrenal gland in stress - Adaptation on a cellular level
SO JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
LA English
DT Review
DE Adrenal; Medulla; Cortex; Stress; Animal models
ID CHRONIC PSYCHOSOCIAL STRESS; ADVERSE CHILDHOOD EXPERIENCES; SOCIAL
   DEFEAT; STEM-CELLS; DEHYDROEPIANDROSTERONE-SULFATE; PSYCHOLOGICAL
   STRESS; CORTISOL SECRETION; METABOLIC SYNDROME; BLOOD-PRESSURE;
   ANIMAL-MODEL
AB Human individuals are constantly confronted to various kinds of stressors and the body's response and adaptation is essential for human health. The adrenal gland as the main producer of stress hormones plays a major role in the response to physiological challenges and is able to adapt to these physiological needs. Proper adaptation is of particular importance since dysregulation of the stress system is the cause of various human diseases including obesity, depression, Parkinson's disease, and post-traumatic stress disorder. Therefore, it is fundamental to understand the physiological, cellular, and molecular underpinnings of the stress adaptation in humans. Because of ethical reasons it is problematic to study the plasticity of the human gland in stress. Hence, various experimental models have been established for the analysis of the functional and cellular role of the adrenal gland adaptation on a translational approach. Here, we summarize the insights of stress-induced adrenal plasticity gained from these models and discuss their relevance to clinical observations.
C1 [Berger, Ilona; Werdermann, Martin; Bornstein, Stefan R.; Steenblock, Charlotte] Tech Univ Dresden, Univ Hosp Carl Gustav Carus, Dept Internal Med 3, D-01307 Dresden, Germany.
   [Bornstein, Stefan R.] Kings Coll London, Diabet & Nutr Sci Div, London WC2R 2LS, England.
C3 Technische Universitat Dresden; Carl Gustav Carus University Hospital;
   University of London; King's College London
RP Steenblock, C (corresponding author), Tech Univ Dresden, Dept Internal Med 3, Fetscherstr 74, D-01307 Dresden, Germany.
EM charlotte.steenblock@uniklinikum-dresden.de
RI Steenblock, Charlotte/C-9038-2018
OI Berger, Ilona/0000-0001-6362-5903; Steenblock,
   Charlotte/0000-0002-9635-4860
FU Deutsche Forschungsgemeinschaft (DFG) [CRC/Transregio 205/1, IRTG2251]
FX This study was supported by the Deutsche Forschungsgemeinschaft (DFG)
   within the CRC/Transregio 205/1 "The Adrenal: Central Relay in Health
   and Disease" and the IRTG2251.
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NR 129
TC 59
Z9 61
U1 1
U2 17
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0960-0760
J9 J STEROID BIOCHEM
JI J. Steroid Biochem. Mol. Biol.
PD JUN
PY 2019
VL 190
BP 198
EP 206
DI 10.1016/j.jsbmb.2019.04.006
PG 9
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA IC6MX
UT WOS:000471087300021
PM 30959152
DA 2025-06-11
ER

PT J
AU Iannotti, RJ
   Wang, J
AF Iannotti, Ronald J.
   Wang, Jing
TI Patterns of Physical Activity, Sedentary Behavior, and Diet in U.S.
   Adolescents
SO JOURNAL OF ADOLESCENT HEALTH
LA English
DT Article
DE Adolescent obesity; Physical activity; Sedentary behavior; Diet; Body
   mass index; Television
ID LATENT CLASS ANALYSIS; METABOLIC SYNDROME; HEALTH; OBESITY; CHILDREN;
   DETERMINANTS; ASSOCIATIONS; RELIABILITY; VALIDITY; FAMILY
AB Objective: To identify patterns in adolescents' obesogenic behaviors and their relations to physical and psychological health.
   Methods: A nationally representative sample of 9,174 U. S. adolescents ages 11 to 16 years was surveyed on physical activity (PA), screen-based sedentary behavior (SB), frequency of consumption of healthy and unhealthy food items, weight status, weight control behavior, depression, physical symptoms, body dissatisfaction, overall health, and life satisfaction. Latent class analysis was used to identify patterns of PA, SB, and diet.
   Results: A model with three latent classes best fit the data: Class 1 with high PA and high fruit and vegetable intake and low SB and intake of sweets, soft drinks, chips, and fries; Class 2 with high SB and high intake of sweets, soft drinks, chips, and fries; and Class 3 with low PA, low fruit and vegetable intake, and low intake of sweets, chips, and fries. Membership in the three classes was related to age, gender, race/ethnicity, and socioeconomic status. In addition, members of Class 1 (26.5%) were more likely to be of normal weight status and to fare well on most of the other health indices; of Class 2 (26.4%) were less likely to be trying to lose weight but scored poorly on the mental health indices; and of Class 3 (47.2%) were less likely to be underweight and reported greater body dissatisfaction.
   Conclusions: Three prevalent patterns of adolescent obesogenic behaviors were identified and these patterns related to weight status, depression, and other indicators of physical and psychological health. Published by Elsevier Inc. on behalf of Society for Adolescent Health and Medicine.
C1 [Iannotti, Ronald J.; Wang, Jing] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Prevent Res Branch, Bethesda, MD 20892 USA.
C3 National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver
   National Institute of Child Health & Human Development (NICHD)
RP Iannotti, RJ (corresponding author), Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Prevent Res Branch, 6100 Execut Blvd,7B05, Bethesda, MD 20892 USA.
EM iannottr@mail.nih.gov
FU Eunice Kennedy Shriver National Institute of Child Health and Human
   Development [N01-HD-5-3401]; Maternal and Child Health Bureau of the
   Health Resources and Services Administration
FX This research was supported in part by the intramural research program
   of the Eunice Kennedy Shriver National Institute of Child Health and
   Human Development (Contract N01-HD-5-3401) and by the Maternal and Child
   Health Bureau of the Health Resources and Services Administration with
   the first author (Ronald J. Iannotti) as principal investigator. This
   work was previously reported at the International Society for Behavioral
   Nutrition and Physical Activity.
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NR 40
TC 85
Z9 102
U1 1
U2 72
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1054-139X
EI 1879-1972
J9 J ADOLESCENT HEALTH
JI J. Adolesc. Health
PD AUG
PY 2013
VL 53
IS 2
BP 280
EP 286
DI 10.1016/j.jadohealth.2013.03.007
PG 7
WC Psychology, Developmental; Public, Environmental & Occupational Health;
   Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Public, Environmental & Occupational Health; Pediatrics
GA 186SM
UT WOS:000322065100020
PM 23642973
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Kunin-Batson, AS
   Haapala, J
   Crain, AL
   Gunnar, MR
   Kharbanda, EO
   Kelly, AS
   Seburg, EM
   Sherwood, NE
   French, SA
AF Kunin-Batson, Alicia S.
   Haapala, Jacob
   Crain, A. Lauren
   Gunnar, Megan R.
   Kharbanda, Elyse O.
   Kelly, Aaron S.
   Seburg, Elisabeth M.
   Sherwood, Nancy E.
   French, Simone A.
TI Cumulative environmental stress and emerging cardiometabolic risk during
   childhood
SO PEDIATRIC OBESITY
LA English
DT Article
DE childhood; health disparities; obesity; stress
ID CORONARY-HEART-DISEASE; SOCIOECONOMIC POSITION; BLOOD-PRESSURE;
   ADULTHOOD; HEALTH; NEIGHBORHOOD; CHILDREN; LINKING; OBESITY; INCOME
AB Objective: To prospectively evaluate the relationship between cumulative environmental stress and cardiometabolic risk in middle childhood, and to examine whether hair cortisol, a measure of hypothalamic pituitary adrenal-axis activity, mediates this relationship. Methods; In a cohort of children from low-income households (n = 320; 59% Hispanic, 23% Black, body mass index (BMI) percentile >50th at enrollment), environmental stressors including family and neighbourhood factors representing disadvantage/deprivation, and cortisol concentrations from hair samples, were measured over five timepoints beginning when children were 2-4 years old. Cardiometabolic risk factors (i.e., BMI, blood pressure, lipids, blood sugar, C-reactive protein) were measured at the final timepoint when children were 7-11 years of age. Results: In adjusted logistic regression models, greater cumulative environmental stress was associated with a higher likelihood of elevated cardiometabolic risk in middle childhood (p = 0.01). Children from minoritized racial/ethnic groups had a higher prevalence of both stressors and cardiometabolic risk factors. Cumulative environmental stress was associated with higher hair cortisol concentrations (p < 0.01). However, hair cortisol was not directly associated with cardiometabolic risk factors and did not explain the association between environmental stress and cardiometabolic risk in causal mediation analysis. Conclusions: The influence of cumulative stress on cardiometabolic health can be observed in middle childhood and may contribute to cardiometabolic health disparities, highlighting the importance of public health interventions to mitigate disadvantage.
C1 [Kunin-Batson, Alicia S.; Kelly, Aaron S.] Univ Minnesota, Med Sch, Dept Pediat, Minneapolis, MN USA.
   [Kunin-Batson, Alicia S.; Kelly, Aaron S.] Univ Minnesota, Ctr Pediat Obes Med, Med Sch, Minneapolis, MN USA.
   [Haapala, Jacob; Crain, A. Lauren; Kharbanda, Elyse O.; Seburg, Elisabeth M.] HealthPartners Inst, Bloomington, MN USA.
   [Gunnar, Megan R.] Univ Minnesota, Inst Child Dev, Minneapolis, MN USA.
   [Sherwood, Nancy E.; French, Simone A.] Univ Minnesota, Sch Publ Hlth, Div Epidemiol & Community Hlth, Minneapolis, MN USA.
   [Kunin-Batson, Alicia S.] Univ Minnesota, Med Sch, Dept Pediat, 717 Delaware St SE, Minneapolis, MN 55414 USA.
   [Kunin-Batson, Alicia S.] Univ Minnesota, Ctr Pediat Obes Med, Med Sch, 717 Delaware St SE, Minneapolis, MN 55414 USA.
C3 University of Minnesota System; University of Minnesota Twin Cities;
   University of Minnesota System; University of Minnesota Twin Cities;
   HealthPartners Institute for Education & Research; University of
   Minnesota System; University of Minnesota Twin Cities; University of
   Minnesota System; University of Minnesota Twin Cities; University of
   Minnesota System; University of Minnesota Twin Cities; University of
   Minnesota System; University of Minnesota Twin Cities
RP Kunin-Batson, AS (corresponding author), Univ Minnesota, Med Sch, Dept Pediat, 717 Delaware St SE, Minneapolis, MN 55414 USA.; Kunin-Batson, AS (corresponding author), Univ Minnesota, Ctr Pediat Obes Med, Med Sch, 717 Delaware St SE, Minneapolis, MN 55414 USA.
EM kunin003@umn.edu
RI Kunin-Batson, Alicia/GQY-8621-2022
OI French, Simone/0000-0003-3413-5985; Kharbanda,
   Elyse/0000-0003-1806-6502; Sherwood, Nancy/0000-0002-3365-9018;
   Kunin-Batson, Alicia/0000-0002-7607-5602
FU Eunice Kennedy Shriver National Institute of Child Health and Human
   Development [R01HD090059, U01HD068990]; Eunice Kennedy Shriver National
   Institute of Child Health and Human Development of the National
   Institutes of Health; Center for Neurobehavioral Development, University
   of Minnesota
FX This work was supported by the Eunice Kennedy Shriver National Institute
   of Child Health and Human Development of the National Institutes of
   Health under award numbers R01HD090059 and U01HD068990, and in part by
   the Center for Neurobehavioral Development, University of Minnesota. The
   content is solely the responsibility of the authors and does not
   necessarily represent the official views of the funders.
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NR 57
TC 2
Z9 2
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2047-6310
EI 2047-6302
J9 PEDIATR OBES
JI Pediatr. Obes.
PD JUN
PY 2024
VL 19
IS 6
DI 10.1111/ijpo.13116
EA MAR 2024
PG 9
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA QM6G9
UT WOS:001193897300001
PM 38549289
OA hybrid
DA 2025-06-11
ER

PT J
AU Haidara, M
   Mikhailidis, DP
   Yassin, HZ
   Dobutovic, B
   Smiljanic, KT
   Soskic, S
   Mousa, SA
   Rizzo, M
   Isenovic, ER
AF Haidara, Mohamed
   Mikhailidis, Dimitri P.
   Yassin, Hanaa Z.
   Dobutovic, Branislava
   Smiljanic, Katarina T.
   Soskic, Sanja
   Mousa, Shaker A.
   Rizzo, Manfredi
   Isenovic, Esma R.
TI Evaluation of the Possible Contribution of Antioxidants Administration
   in Metabolic Syndrome
SO CURRENT PHARMACEUTICAL DESIGN
LA English
DT Review
DE antioxidants; cardiovascular disease; insulin resistance; metabolic
   syndrome; oxidative stress; reactive oxygen species
ID LOW-DENSITY-LIPOPROTEIN; CORONARY-HEART-DISEASE; NITRIC-OXIDE SYNTHASE;
   FATTY LIVER-DISEASE; PLASMINOGEN-ACTIVATOR INHIBITOR-1; VITAMIN-E
   SUPPLEMENTATION; INSULIN-RESISTANCE SYNDROME; CHRONIC KIDNEY-DISEASE;
   HUMAN ADIPOSE-TISSUE; ALPHA-LIPOIC ACID
AB The metabolic syndrome (MetS) is common, and its associated risk burdens of diabetes and cardiovascular disease (CVD) are a major public health problem. The hypothesis that main constituent parameters of the MetS share common pathophysiologic mechanisms provides a conceptual framework for the future research. Exercise and weight loss can prevent insulin resistance and reduce the risk of diseases associated with the MetS. Interrupting intracellular and extracellular reactive oxygen species (ROS) overproduction could also contribute to normalizing the activation of metabolic pathways leading to the onset of diabetes, endothelial dysfunction, and cardiovascular (CV) complications. On the other hand, it is difficult to counteract the development of CV complications by using conventional antioxidants. Indeed, interest has focused on strategies that enhance the removal of ROS using either antioxidants or drugs that enhance endogenous antioxidant defense. Although these strategies have been effective in laboratory experiments, several clinical trials have shown that they do not reduce CV events, and in some cases antioxidants have actually worsened the outcome. More research is needed in this field.
C1 [Haidara, Mohamed] Univ Belgrade, Inst Vinca, Lab Radiobiol & Mol Genet, Dept Mol Genet & Radiobiol, Belgrade 11000, Serbia.
   [Haidara, Mohamed; Yassin, Hanaa Z.] Cairo Univ, Kasr Al Aini Fac Med, Dept Physiol, Cairo, Egypt.
   [Mikhailidis, Dimitri P.] UCL, Vasc Dis Prevent Clin, Univ Coll London Med Sch, Dept Clin Biochem, London NW3 2QG, England.
   [Mousa, Shaker A.] Albany Coll Pharm & Hlth Sci, Pharmaceut Res Inst, Rensselaer, NY 12144 USA.
   [Rizzo, Manfredi] Univ Palermo, Dept Internal Med & Med Specialties, I-90133 Palermo, Italy.
C3 University of Belgrade; Egyptian Knowledge Bank (EKB); Cairo University;
   University of London; University College London; Albany College of
   Pharmacy & Health Sciences; University of Palermo
RP Haidara, M (corresponding author), Univ Belgrade, Inst Vinca, Lab Radiobiol & Mol Genet, Dept Mol Genet & Radiobiol, POB 522, Belgrade 11000, Serbia.
EM isenovic@yahoo.com
RI Isenovic, Esma/D-3017-2009; Yassin, Hanaa/AAN-6144-2020; Dobutovic,
   Branislava/A-4976-2010; RIZZO, MANFREDI/GZL-0551-2022; Mikhailidis,
   Dimitri/A-1869-2013; Mousa, Shaker/A-7151-2017; Haidara,
   Mohamed/E-5734-2010; Smiljanic, Katarina/Q-9573-2016
OI Isenovic, Esma/0000-0002-0012-2636; Soskic, Sanja/0000-0002-9482-6940;
   Mousa, Shaker/0000-0002-9294-015X; Haidara, Mohamed/0000-0003-0990-8093;
   RIZZO, Manfredi/0000-0002-9549-8504; Smiljanic,
   Katarina/0000-0003-4774-8895
FU Kasr Al-Aini Research Centre; Ministry of Science, Republic of Serbia
   [173033]
FX This work is part of collaboration between University College of London,
   UK, University of Palermo Italy, the PRI at Albany College of Pharmacy
   and Health Sciences, USA, Cairo University, Egypt and Institute Vinca,
   Serbia and is supported by grants from the Kasr Al-Aini Research Centre
   and the grant No. 173033 (to E.R.I) from the Ministry of Science,
   Republic of Serbia.
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NR 219
TC 19
Z9 21
U1 0
U2 5
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1381-6128
EI 1873-4286
J9 CURR PHARM DESIGN
JI Curr. Pharm. Design
PD NOV
PY 2011
VL 17
IS 33
BP 3699
EP 3712
DI 10.2174/138161211798220882
PG 14
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 883MJ
UT WOS:000299638000010
PM 22074439
DA 2025-06-11
ER

PT J
AU Matsha, TE
   Macharia, M
   Yako, YY
   Erasmus, RT
   Hassan, MS
   Kengne, AP
AF Matsha, Tandi Edith
   Macharia, Muiruri
   Yako, Yandiswa Yolanda
   Erasmus, Rajiv Timothy
   Hassan, Mogamat Shafick
   Kengne, Andre Pascal
TI Gamma-glutamyltransferase, insulin resistance and cardiometabolic risk
   profile in a middle-aged African population
SO EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
LA English
DT Article
DE Gamma-glutamyltransferase; insulin resistance; metabolic syndrome;
   cardiovascular risk; South Africa
ID METABOLIC SYNDROME; ALANINE AMINOTRANSFERASE; CARDIOVASCULAR-DISEASE;
   COLORED POPULATION; DIABETES-MELLITUS; OXIDATIVE STRESS; LIVER-ENZYMES;
   JAPANESE MEN; FOLLOW-UP; TRANSPEPTIDASE
AB Background Mechanisms linking liver functions with cardiometabolic risk may involve insulin resistance (IR) and non-alcoholic fatty liver disease. We assessed the associations of gamma-glutamyltransferase (GGT) levels with IR and metabolic syndrome (MetS) in an adult South African urban cohort.
   Methods 1198 participants aged >15 years (297 men) were drawn from the Bellville-South suburb (Cape Town). The homeostatic model assessment of insulin (HOMA-IR), -cells function (HOMA-B%), fasting insulin resistance index (FIRI) and the quantitative insulin-sensitivity check index (QUICKI) were calculated, and MetS defined according to the Join Interim Statement 2009 criteria. Associations of GGT levels with covariates were assessed on a continuous scale and across sex-specific quarters of GGT, with adjustment for confounders via generalized linear and logistic regressions.
   Results Indicators of IR (HOMA-IR, FIRI and fasting insulin) increased, whereas those for insulin sensitivity (Sib and QUICKI) diminished significantly linearly and across increasing GGT quarters. In multivariable-adjusted models, adjustment for sex, age, BMI, cigarette smoking and alcohol intake yielded the strongest, significant associations between GGT and all markers of IR/IS and glycemia excluding glucose insulin ratio. In a similar level of adjustments, with/without further adjustment for markers of IR/insulin sensitivity, the prevalence of MetS significantly increased across quarters of GGT.
   Conclusions GGT levels were independently associated with insulin sensitivity and MetS in this population. Unaccounted, chronic elevation of GGT may therefore be a cue to screen and monitor individuals for MetS and diabetes, and may warrant consideration as an indicator of high risk for the development of these metabolic disorders.
C1 [Matsha, Tandi Edith; Yako, Yandiswa Yolanda; Hassan, Mogamat Shafick] Cape Peninsula Univ Technol, Dept Biomed Technol, Cape Town, South Africa.
   [Macharia, Muiruri; Erasmus, Rajiv Timothy] Univ Stellenbosch, Div Chem Pathol, ZA-7600 Stellenbosch, South Africa.
   [Kengne, Andre Pascal] South African Med Res Council, NCRP Cardiovasc & Metab Dis, ZA-7505 Cape Town, South Africa.
   [Kengne, Andre Pascal] Univ Cape Town, ZA-7700 Rondebosch, South Africa.
C3 Cape Peninsula University of Technology; Stellenbosch University; South
   African Medical Research Council; University of Cape Town
RP Kengne, AP (corresponding author), South African Med Res Council, POB 19070 Tygerberg, ZA-7505 Cape Town, South Africa.
EM andre.kengne@mrc.ac.za
RI Kengne, Andre/ABB-3696-2020
OI Matsha, Tandi/0000-0001-5251-030X; Kengne, Andre
   Pascal/0000-0002-5183-131X; Macharia, Muiruri/0000-0002-5508-274X
FU University Research Fund of the Cape Peninsula University of Technology,
   South Africa
FX Data collection for the investigations leading to this manuscript was
   supported by a grant from the University Research Fund of the Cape
   Peninsula University of Technology, South Africa. The above-mentioned
   funding sources played no role in this publication besides funding the
   project.
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NR 34
TC 13
Z9 13
U1 0
U2 6
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 2047-4873
EI 2047-4881
J9 EUR J PREV CARDIOL
JI Eur. J. Prev. Cardiol.
PD DEC
PY 2014
VL 21
IS 12
BP 1541
EP 1548
DI 10.1177/2047487313501967
PG 8
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA AT9CF
UT WOS:000345224900011
PM 23945039
OA Bronze
DA 2025-06-11
ER

PT J
AU Devlin, AM
   Panagiotopoulos, C
AF Devlin, Angela M.
   Panagiotopoulos, Constadina
TI Metabolic side effects and pharmacogenetics of second-generation
   antipsychotics in children
SO PHARMACOGENOMICS
LA English
DT Review
DE cardiometabolic dysfunction; children; gene variants; second-generation
   antipsychotics; side effects; weight gain
ID INDUCED WEIGHT-GAIN; INTIMA-MEDIA THICKNESS; EARLY-ONSET SCHIZOPHRENIA;
   CORONARY-HEART-DISEASE; 5-HT2C RECEPTOR GENE; CARDIOVASCULAR RISK;
   BLOOD-PRESSURE; YOUNG FINNS; METHYLENETETRAHYDROFOLATE REDUCTASE;
   CARDIOMETABOLIC RISK
AB Second-generation antipsychotics (SGAs) are increasingly being used to treat children for a range of mental health conditions, for example, anxiety disorder, attention deficit hyperactivity disorder and bipolar disorder. SGA treatment is associated with weight gain and cardiometabolic side effects such as dyslipidemia, insulin resistance and elevated blood pressure, in some, but not all children. This review provides an overview of the potential role of pharmacogenomics in predisposing a child to unhealthy weight gain and cardiometabolic side effects with SGA treatment. Specifically, the review includes a synopsis of the evidence for cardiometabolic side effects in SGA-treated children, illustrating the extent and depth of the problem; summarizes the potential long-term consequences of developing cardiometabolic risk during childhood and highlights genetic variants that may be useful in predicting cardiometabolic side effects in SGA-treated children.
C1 [Devlin, Angela M.; Panagiotopoulos, Constadina] Univ British Columbia, Child & Family Res Inst, Dept Pediat, Vancouver, BC V5Z 4H4, Canada.
C3 University of British Columbia; Child & Family Research Institute
RP Devlin, AM (corresponding author), Univ British Columbia, Child & Family Res Inst, Dept Pediat, 272-950 West 28th Ave, Vancouver, BC V5Z 4H4, Canada.
EM adevlin@cfri.ubc.ca
RI Panagiotopoulos, Constadina/AAO-6827-2020
OI Panagiotopoulos, Constadina/0000-0002-1379-7472; Devlin,
   Angela/0000-0002-1390-6587
FU Canadian Institute of Health Research [MOP-133399]; Natural Sciences and
   Engineering Research Council of Canada [RG-PGP-2014-00066]; British
   Columbia Mental Health and Substance Use Services; Child and Family
   Research Institute
FX AM Devlin is supported by research grants from the Canadian Institute of
   Health Research (MOP-133399), Natural Sciences and Engineering Research
   Council of Canada (RG-PGP-2014-00066), and British Columbia Mental
   Health and Substance Use Services. She is also supported by an
   Investigator award from the Child and Family Research Institute. C
   Panagiotopoulos is supported by a research grant from British Columbia
   Mental Health and Substance Use Services. The authors have no other
   relevant affiliations or financial involvement with any organization or
   entity with a financial interest in or financial conflict with the
   subject matter or materials discussed in the manuscript apart from those
   disclosed.
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NR 103
TC 15
Z9 17
U1 0
U2 16
PU FUTURE MEDICINE LTD
PI LONDON
PA UNITEC HOUSE, 3RD FLOOR, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON, N3
   1QB, ENGLAND
SN 1462-2416
EI 1744-8042
J9 PHARMACOGENOMICS
JI Pharmacogenomics
PY 2015
VL 16
IS 9
BP 981
EP 996
DI 10.2217/pgs.15.55
PG 16
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA CM7IJ
UT WOS:000357864700008
PM 26107755
DA 2025-06-11
ER

PT J
AU Navarrete-Muñoz, EM
   Vioque, J
   Toledo, E
   Oncina-Canovas, A
   Martínez-González, MA
   Salas-Salvadó, J
   Corella, D
   Fitó, M
   Romaguera, D
   Alonso-Gómez, AM
   Wärnberg, J
   Martínez, JA
   Serra-Majem, L
   Estruch, R
   Tinahones, FJ
   Lapetra, J
   Pintó, X
   Tur, JA
   López-Miranda, J
   Bueno-Cavanillas, A
   Matía-Martín, P
   Daimiel, L
   Sánchez, VM
   Vidal, J
   Blanco, AID
   Ros, E
   Diez-Espino, J
   Babio, N
   Fernandez-Carrion, R
   Castañer, O
   Colom, A
   Compañ-Gabucio, L
   Lete, IS
   Crespo-Oliva, E
   Abete, I
   Tomaino, L
   Casas, R
   Fernandez-Garcia, JC
   Santos-Lozano, JM
   Sarasa, I
   Garcia-Rios, JMA
   Martín-Pelaez, S
   Ruiz-Canela, M
   Díaz-López, A
   Martinez-Lacruz, R
   Zomeño, MD
   Rayó, E
   Selles, CG
   Canudas, S
   Goday, A
   García-de-la-Hera, M
AF Navarrete-Munoz, Eva-Maria
   Vioque, Jesus
   Toledo, Estefania
   Oncina-Canovas, Alejando
   Angel Martinez-Gonzalez, Miguel
   Salas-Salvado, Jordi
   Corella, Dolores
   Fito, Montserrat
   Romaguera, Dora
   Alonso-Gomez, Angel M.
   Warnberg, Julia
   Alfredo Martinez, J.
   Serra-Majem, Luis
   Estruch, Ramon
   Tinahones, Francisco J.
   Lapetra, Jose
   Pinto, Xavier
   Tur, Josep A.
   Lopez-Miranda, Jose
   Bueno-Cavanillas, Aurora
   Matia-Martin, Pilar
   Daimiel, Lidia
   Martin Sanchez, Vicente
   Vidal, Josep
   de Cos Blanco, Ana Isabel
   Ros, Emili
   Diez-Espino, Javier
   Babio, Nancy
   Fernandez-Carrion, Rebeca
   Castaner, Olga
   Colom, Antoni
   Compan-Gabucio, Laura
   Salaverria Lete, Itziar
   Crespo-Oliva, Edelys
   Abete, Itziar
   Tomaino, Laura
   Casas, Rosa
   Carlos Fernandez-Garcia, Jose
   Manuel Santos-Lozano, Jose
   Sarasa, Iziar
   Antonio Garcia-Rios, Jose M.
   Martin-Pelaez, Sandra
   Ruiz-Canela, Miguel
   Diaz-Lopez, Andres
   Martinez-Lacruz, Raul
   Dolors Zomeno, Maria
   Rayo, Elena
   Gisbert Selles, Cristina
   Canudas, Silvia
   Goday, Albert
   Garcia-de-la-Hera, Manoli
TI Dietary folate intake and metabolic syndrome in participants of
   PREDIMED-Plus study: a cross-sectional study
SO EUROPEAN JOURNAL OF NUTRITION
LA English
DT Article
DE Folate; Cardiometabolic risk; Metabolic syndrome score; Diabetes;
   Cholesterol
ID FOLIC-ACID SUPPLEMENTATION; INSULIN-RESISTANCE; HOMOCYSTEINE; ADULTS;
   METAANALYSIS; PREVALENCE; ASSOCIATION; POPULATION; DISEASES; STRESS
AB Purpose We examined the association between dietary folate intake and a score of MetS (metabolic syndrome) and its components among older adults at higher cardiometabolic risk participating in the PREDIMED-Plus trial. Methods A cross-sectional analysis with 6633 with overweight/obesity participants with MetS was conducted. Folate intake (per 100 mcg/day and in quintiles) was estimated using a validated food frequency questionnaire. We calculated a MetS score using the standardized values as shown in the formula: [(body mass index + waist-to-height ratio)/2] + [(systolic blood pressure + diastolic blood pressure)/2] + plasma fasting glucose-HDL cholesterol + plasma triglycerides. The MetS score as continuous variable and its seven components were the outcome variables. Multiple robust linear regression using MM-type estimator was performed to evaluate the association adjusting for potential confounders. Results We observed that an increase in energy-adjusted folate intake was associated with a reduction of MetS score (beta for 100 mcg/day = - 0.12; 95% CI: - 0.19 to - 0.05), and plasma fasting glucose (beta = - 0.03; 95% CI: - 0.05 to - 0.02) independently of the adherence to Mediterranean diet and other potential confounders. We also found a positive association with HDL-cholesterol (beta = 0.07; 95% CI: 0.04-0.10). These associations were also observed when quintiles of energy-adjusted folate intake were used instead. Conclusion This study suggests that a higher folate intake may be associated with a lower MetS score in older adults, a lower plasma fasting glucose, and a greater HDL cholesterol in high-risk cardio-metabolic subjects.
C1 [Navarrete-Munoz, Eva-Maria] Miguel Hernandez Univ, Dept Surg & Pathol, Grp Invest Terapia Ocupac InTeO, Alicante 03550, Spain.
   [Vioque, Jesus; Bueno-Cavanillas, Aurora; Martin Sanchez, Vicente; Garcia-de-la-Hera, Manoli] Inst Hlth Carlos III, CIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain.
   [Vioque, Jesus; Oncina-Canovas, Alejando; Compan-Gabucio, Laura; Garcia-de-la-Hera, Manoli] Univ Miguel Hernandez, Nutr Epidemiol Unit, ISABIAL UMH, Alicante, Spain.
   [Toledo, Estefania; Angel Martinez-Gonzalez, Miguel; Salas-Salvado, Jordi; Corella, Dolores; Fito, Montserrat; Romaguera, Dora; Alonso-Gomez, Angel M.; Warnberg, Julia; Alfredo Martinez, J.; Serra-Majem, Luis; Estruch, Ramon; Tinahones, Francisco J.; Lapetra, Jose; Pinto, Xavier; Tur, Josep A.; Lopez-Miranda, Jose; de Cos Blanco, Ana Isabel; Ros, Emili; Diez-Espino, Javier; Babio, Nancy; Fernandez-Carrion, Rebeca; Castaner, Olga; Crespo-Oliva, Edelys; Abete, Itziar; Tomaino, Laura; Casas, Rosa; Carlos Fernandez-Garcia, Jose; Manuel Santos-Lozano, Jose; Antonio Garcia-Rios, Jose M.; Ruiz-Canela, Miguel; Diaz-Lopez, Andres; Martinez-Lacruz, Raul; Dolors Zomeno, Maria; Canudas, Silvia; Goday, Albert] Ctr Invest Biomed Red Fisiopatol Obesidad & Nutr, Inst Hlth Carlos III, Madrid, Spain.
   [Toledo, Estefania; Angel Martinez-Gonzalez, Miguel; Diez-Espino, Javier; Ruiz-Canela, Miguel] Univ Navarra, Dept Prevent Med & Publ Hlth, IdiSNA, Pamplona, Spain.
   [Angel Martinez-Gonzalez, Miguel] Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA.
   [Salas-Salvado, Jordi; Babio, Nancy; Diaz-Lopez, Andres; Canudas, Silvia] Univ Rovira & Virgili, Dept Bioquim & Biotecnol, Unitat Nutr, Reus, Spain.
   [Salas-Salvado, Jordi; Babio, Nancy; Diaz-Lopez, Andres; Canudas, Silvia] Univ Hosp St Joan de Reus, Nutr Unit, Reus, Spain.
   [Salas-Salvado, Jordi; Babio, Nancy; Diaz-Lopez, Andres; Canudas, Silvia] Inst Invest Sanitaria Pere Virgili IISPV, Reus, Spain.
   [Corella, Dolores; Fernandez-Carrion, Rebeca; Martinez-Lacruz, Raul] Univ Valencia, Dept Prevent Med, Valencia, Spain.
   [Fito, Montserrat; Castaner, Olga; Dolors Zomeno, Maria; Goday, Albert] Inst Hosp del Mar Invest Med Municipal Invest Med, Unit Cardiovasc Risk & Nutr, Barcelona, Spain.
   [Romaguera, Dora; Tur, Josep A.; Colom, Antoni; Rayo, Elena] Univ Hosp Son Espases, Hlth Res Inst Balear Isl IdISBa, Palma De Mallorca, Spain.
   [Alonso-Gomez, Angel M.; Salaverria Lete, Itziar] Univ Basque Country UPV EHU, Araba Univ Hosp, Bioaraba Hlth Res Inst, Osakidetza Basque Hlth Serv, Vitoria, Spain.
   [Warnberg, Julia; Crespo-Oliva, Edelys] Univ Malaga, Sch Hlth Sci, Dept Nursing, Inst Biomed Res Malaga IBIMA, Malaga, Spain.
   [Alfredo Martinez, J.; Abete, Itziar] Univ Navarra, Ctr Nutr Res, Dept Nutr Food Sci & Physiol, Pamplona, Spain.
   [Serra-Majem, Luis; Tomaino, Laura] Univ Palmas Gran Canaria, Res Inst Biomed & Hlth Sci IUIBS, Las Palmas Gran Canaria, Spain.
   [Serra-Majem, Luis; Tomaino, Laura] Ctr Hosp Univ Insular Materno Infantil CHUIMI, Canarian Hlth Serv, Las Palmas Gran Canaria, Spain.
   [Estruch, Ramon; Casas, Rosa] Univ Barcelona, Hosp Clin, Inst Investigac Biomed August Pi Sunyer IDIBAPS, Dept Internal Med, Barcelona, Spain.
   [Tinahones, Francisco J.; Carlos Fernandez-Garcia, Jose] Univ Malaga, Virgen Victoria Hosp, Inst Invest Biomed Malaga IBIMA, Dept Endocrinol, Malaga, Spain.
   [Lapetra, Jose; Manuel Santos-Lozano, Jose] Dist Sanitario Atenc Primaria Sevilla, Res Unit, Dept Family Med, Seville, Spain.
   [Pinto, Xavier; Sarasa, Iziar] Hosp Univ Bellvitge, Hospitalet Llobregat, Lipids & Vasc Risk Unit, Internal Med, Barcelona, Spain.
   [Tur, Josep A.] Univ Balearic Isl, Res Grp Community Nutr & Oxidat Stress, Palma De Mallorca, Spain.
   [Lopez-Miranda, Jose; Antonio Garcia-Rios, Jose M.] Univ Cordoba, Reina Sofia Univ Hosp, Maimonides Biomed Res Inst Cordoba Imib, Dept Internal Med, Cordoba, Spain.
   [Bueno-Cavanillas, Aurora; Martin-Pelaez, Sandra] Univ Granada, Dept Prevent Med & Publ Hlth, Granada, Spain.
   [Matia-Martin, Pilar] Inst Invest Sanitaria Hosp Clin San Carlos IdISSC, Dept Endocrinol & Nutr, Madrid, Spain.
   [Daimiel, Lidia] IMDEA Food, CEI UAM CSIC, Precis Nutr & Obes Program, Nutr Control Epigenom Grp, Madrid, Spain.
   [Martin Sanchez, Vicente] Univ Leon, Inst Biomed IBIOMED, Leon, Spain.
   [Vidal, Josep] Inst Salud Carlos III ISCIII, CIBER Diabet & Enfermedades Metab CIBERDEM, Madrid, Spain.
   [Vidal, Josep] Univ Barcelona, Hosp Clin, Inst Investigac Biomed August Pi Sunyer IDIBAPS, Dept Endocrinol, Barcelona, Spain.
   [de Cos Blanco, Ana Isabel] Univ Autonoma, Hosp Fdn Jimenez Diaz, Inst Invest Biomed IISFJD, Dept Endocrinol & Nutr, Madrid, Spain.
   [Ros, Emili] Hosp Clin Barcelona, Inst Investigac Biomed August Pi Sunyer IDIBAPS, Dept Endocrinol & Nutr, Lipid Clin, Barcelona, Spain.
   [Diez-Espino, Javier] Serv Navarro Salud Osasunbidea, Gerencia Atenc Primaria, Pamplona, Spain.
   [Tomaino, Laura] Univ Milan, Dept Clin & Community Hlth DISCCO, Milan, Italy.
   [Gisbert Selles, Cristina] Ctr Salud San Vicente Raspeig, Alicante, Spain.
   [Vioque, Jesus] Univ Miguel Hernandez, Dept Salud Publ, Campus San Juan,Ctra Nacl 332 S-N, Sant Joan dAlacant 03550, Spain.
C3 Universidad Miguel Hernandez de Elche; CIBER - Centro de Investigacion
   Biomedica en Red; CIBERESP; General University Hospital of Alicante;
   Universidad Miguel Hernandez de Elche; Universitat d'Alacant; Instituto
   de Investigacion Sanitaria y Biomedica de Alicante (ISABIAL); CIBER -
   Centro de Investigacion Biomedica en Red; CIBEROBN; University of
   Navarra; Harvard University; Harvard T.H. Chan School of Public Health;
   Universitat Rovira i Virgili; Universitat Rovira i Virgili; Institut
   d'Investigacio Sanitaria Pere Virgili (IISPV); University of Valencia;
   Institut Investigacio Sanitaria Illes Balears (IdISBa); Hospital
   Universitari Son Espases; Bioaraba Health Research Institute; University
   Hospital of Araba; University of Basque Country; Instituto de
   Investigacion Biomedica de Malaga y Plataforma en Nanomedicina (IBIMA);
   Universidad de Malaga; University of Navarra; Universidad de Las Palmas
   de Gran Canaria; University of Barcelona; Hospital Clinic de Barcelona;
   IDIBAPS; Universidad de Malaga; Instituto de Investigacion Biomedica de
   Malaga y Plataforma en Nanomedicina (IBIMA); Institut d'Investigacio
   Biomedica de Bellvitge (IDIBELL); Bellvitge University Hospital;
   University of Barcelona; Universitat de les Illes Balears; Universidad
   de Cordoba; University of Granada; Consejo Superior de Investigaciones
   Cientificas (CSIC); IMDEA Food Institute; Universidad de Leon; CIBER -
   Centro de Investigacion Biomedica en Red; CIBERDEM; University of
   Barcelona; Hospital Clinic de Barcelona; IDIBAPS; Fundacion Jimenez
   Diaz; Autonomous University of Madrid; University of Barcelona; Hospital
   Clinic de Barcelona; IDIBAPS; Servicio Navarro de Salud - Osasunbidea;
   University of Milan; Universidad Miguel Hernandez de Elche
RP Vioque, J (corresponding author), Inst Hlth Carlos III, CIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain.; Vioque, J (corresponding author), Univ Miguel Hernandez, Nutr Epidemiol Unit, ISABIAL UMH, Alicante, Spain.; Vioque, J (corresponding author), Univ Miguel Hernandez, Dept Salud Publ, Campus San Juan,Ctra Nacl 332 S-N, Sant Joan dAlacant 03550, Spain.
EM vioque@umh.es
RI Vioque, Jesus/A-1066-2008; MARTIN-PELAEZ, SANDRA/G-4945-2015; Babio,
   Nancy/AAN-2715-2020; Navarrete-Muñoz, Eva/F-1666-2011; Tur,
   Josep/AAE-5748-2020; Castaner, Olga/F-1533-2013; Pintó,
   Xavier/AGI-4297-2022; ALONSO GOMEZ, ANGEL/HLG-2476-2023; Gabucio,
   Laura/AAN-6068-2020; Martinez, Juan/GXM-4393-2022; Estruch,
   Ramon/AAZ-3723-2020; Lopez-Miranda, Jose/Y-8306-2019; Vidal,
   Josep/MIK-6936-2025; Fernandez-Carrion, Rebeca/AAA-5713-2019; Lapetra,
   Jose/F-2552-2015; Garcia de la Hera, Manuela/N-8908-2019; Tinahones,
   Francisco/AAB-2882-2020; Toledo, Estefania/H-6211-2014; Oncina Canovas,
   Alejandro/KOD-0906-2024; Romaguera, Dora/ABE-7004-2020; Corella,
   Dolores/L-9888-2014; Bueno-Cavanillas, Aurora/O-1513-2015; Ruiz-Canela,
   Miguel/JYP-1794-2024; Martinez-Gonzalez, Miguel/AAE-7669-2019; Colom
   Fernandez, Antoni/JHU-4849-2023; Casas, Rosa/ABD-1915-2020;
   Fernandez-Garcia, Jose/B-5312-2013; Fito Colomer, Montse/C-1822-2012;
   Warnberg, Julia/G-1390-2011; Ruiz-Canela, Miguel/I-7738-2016; Martin,
   Vicente/A-1597-2008; Daimiel-Ruiz, Lidia Angeles/M-7779-2014; Canudas,
   Silvia/K-4184-2014; Salas-Salvado, Jordi/C-7229-2017
OI Oncina Canovas, Alejandro/0000-0003-4652-0565; Casas,
   Rosa/0000-0002-0211-9166; Vioque, Jesus/0000-0002-2284-148X; Fito
   Colomer, Montse/0000-0002-1817-483X; Lopez-Miranda,
   Jose/0000-0002-8844-0718; BABIO SANCHEZ, NANCY/0000-0003-3527-5277;
   Compan Gabucio, Laura M/0000-0001-5324-1535; Castaner Nino,
   Olga/0000-0003-3169-997X; Navarrete-Munoz, Eva
   Maria/0000-0002-1494-5676; MARTIN PELAEZ, SANDRA/0000-0002-2193-3913;
   Vidal Cortada, Josep/0000-0002-4564-4518; Warnberg,
   Julia/0000-0002-8408-316X; Ruiz-Canela, Miguel/0000-0002-7684-2787;
   Pinto Sala, Xavier/0000-0002-2216-2444; Tinahones, Francisco
   J/0000-0001-6871-4403; Zomeno, M. Dolores/0000-0003-1280-7680; Martin,
   Vicente/0000-0003-0552-2804; Daimiel-Ruiz, Lidia
   Angeles/0000-0001-9898-6629; Canudas, Silvia/0000-0002-5630-1588;
   Salas-Salvado, Jordi/0000-0003-2700-7459; Gamez/0000-0002-9362-6947;
   Garcia de la Hera, Manuela/0000-0001-5742-2704; Diaz-Lopez,
   Andres/0000-0002-7500-5629; Crespo Oliva, Edelys/0009-0001-2103-925X
FU Cohorte PREDIMED-Plus grant; European Research Council [340918];
   Especial Action Project; Recercaixa grant [2013ACUP00194]; Consejeria de
   Salud de la Junta de Andalucia [PI0458/2013, PS0358/2016, PI0137/2018];
   Generalitat Valenciana [PROMETEO/2017/017]; SEMERGEN grant; European
   Regional Development Fund [CB06/03, CB12/03]; International Nut & Dried
   Fruit Council-FESNAD [201302]; AstraZeneca Young Investigators Award in
   Category of Obesity [T2D 2017]; EU-COST Action [CA16112]; Balearic
   Islands Government [35/2011]; Balearic Islands Health Research Institute
   (IDISBA); ICREA under the ICREA Academia programme; Instituto de Salud
   Carlos III - Fondo Europeo de Desarrollo Regional-FEDER [PI13/00673,
   PI13/00492, PI13/00272, PI13/01123, PI13/00462, PI13/00233, PI13/02184,
   PI13/00728, PI13/01090, PI13/01056, PI14/01722, PI14/00636, PI14/00618,
   PI14/00696, PI14/01206, PI14/01919, PI14/00853, PI14/01374]; 
   [PI16/00473];  [PI16/00662];  [PI16/01873];  [PI16/01094]; 
   [PI16/00501];  [PI16/00533];  [PI16/00381];  [PI16/00366]; 
   [PI16/01522];  [PI16/01120];  [PI17/00764];  [PI17/01183]; 
   [PI17/00855];  [PI17/01347];  [PI17/00525];  [PI17/01827]; 
   [PI17/00532];  [PI17/00215];  [PI17/01441];  [PI17/00508]; 
   [PI17/01732];  [PI17/00926]
FX The PREDIMED-Plus trial was supported by grants from the Instituto de
   Salud Carlos III, co-financed by the Fondo Europeo de Desarrollo
   Regional-FEDER including the following projects: PI13/00673, PI13/00492,
   PI13/00272, PI13/01123, PI13/00462, PI13/00233, PI13/02184, PI13/00728,
   PI13/01090, PI13/01056, PI14/01722, PI14/00636, PI14/00618, PI14/00696,
   PI14/01206, PI14/01919, PI14/00853, PI14/01374, PI16/00473, PI16/00662,
   PI16/01873, PI16/01094, PI16/00501, PI16/00533, PI16/00381, PI16/00366,
   PI16/01522, PI16/01120, PI17/00764, PI17/01183, PI17/00855, PI17/01347,
   PI17/00525, PI17/01827, PI17/00532, PI17/00215, PI17/01441, PI17/00508,
   PI17/01732, and PI17/00926; the Cohorte PREDIMED-Plus grant; the
   European Research Council (Advanced Research Grant 2013-2018, 340918) to
   M.A.M.-G., the Especial Action Project entitled: Implementacion y
   evaluacion de una intervencion intensiva sobre la actividad fisica
   Cohorte PREDIMED-Plus grant to J.S.-S., the Recercaixa grant to J.S.-S.
   (2013ACUP00194), grants from the Consejeria de Salud de la Junta de
   Andalucia (PI0458/2013, PS0358/2016, and PI0137/2018), a grant from the
   Generalitat Valenciana (PROMETEO/2017/017), a SEMERGEN grant, and funds
   from the European Regional Development Fund (CB06/03 and CB12/03), The
   International Nut & Dried Fruit Council-FESNAD (Long-term effects of an
   energy-restricted Mediterranean diet on mortality and cardiovascular
   disease 2014-2015, No. 201302) [M.A.M.G.]; the AstraZeneca Young
   Investigators Award in Category of Obesity and T2D 2017 [D.R.], EU-COST
   Action CA16112, Grant of support to research groups no. 35/2011 from the
   Balearic Islands Government, Grants from Balearic Islands Health
   Research Institute (IDISBA). This work is partially supported by ICREA
   under the ICREA Academia programme. None of the funding sources took
   part in the design, collection, analysis, or interpretation of the data
   or in the decision to submit the manuscript for publication.
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NR 53
TC 15
Z9 16
U1 1
U2 23
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1436-6207
EI 1436-6215
J9 EUR J NUTR
JI Eur. J. Nutr.
PD MAR
PY 2021
VL 60
IS 2
BP 1125
EP 1136
DI 10.1007/s00394-020-02364-4
EA AUG 2020
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA QK8PU
UT WOS:000562326900001
PM 32833162
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Kim, Y
   Kim, HY
AF Kim, Yunmi
   Kim, Hyun-Young
TI Association Between Depression and Metabolic Syndrome in Korean Adults:
   Data From the 2014 and 2016 Korea National Health and Nutrition
   Examination Survey
SO ASIA-PACIFIC JOURNAL OF PUBLIC HEALTH
LA English
DT Article
DE adult; depression; Korean; metabolic syndrome; PHQ-9
ID QUALITY-OF-LIFE; QUESTIONNAIRE PHQ-9; PREVALENCE; MORTALITY; SYMPTOMS;
   OBESITY; RISK
AB This study aimed to examine the association of depression with metabolic syndrome and to investigate levels of awareness and treatment of depression in Korean adults. We analyzed data extracted from the Korea National Health and Nutrition Examination Survey (2014 and 2016) using the Patient Health Questionnaire-9 depression screening instrument. Among the survey participants, 10 459 were selected for data analysis. Of them, 7.2% had depression, 24.4% had metabolic syndrome, and 10.0% had both depression and metabolic syndrome. Among those with depression, 33.1% were aware of their condition and 25.7% received treatment, with significant differences found between those with and without metabolic syndrome. The mean Patient Health Questionnaire-9 scores significantly increased with the number of metabolic syndrome components (F = 6.06, P = <.001). In logistic regression analysis, the odds ratio (OR) for depression with metabolic syndrome was 1.41 (95% confidence interval [CI] = 1.12-1.76). For the number of metabolic syndrome components, having 2 (OR = 1.37, 95% CI = 1.01-1.86), 3 (OR = 1.57, 95% CI = 1.12-2.21), 4 (OR = 1.95, 95% CI = 1.32-2.87), and 5 (OR = 2.18, 95% CI = 1.38-3.46) conditions significantly increased the OR for depression. Including depression in the management of metabolic syndrome could help make people with depression more aware of their condition.
C1 [Kim, Yunmi] Eulji Univ, Seongnam Si, South Korea.
   [Kim, Hyun-Young] Jeonju Univ, Jeonju Si, South Korea.
C3 Eulji University; Jeonju University
RP Kim, HY (corresponding author), Jeonju Univ, Dept Nursing, 303 Cheonjam Ro, Jeonju Si 55069, South Korea.
EM flowhykim@gmail.com
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NR 32
TC 12
Z9 13
U1 0
U2 5
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1010-5395
EI 1941-2479
J9 ASIA-PAC J PUBLIC HE
JI Asia-Pac. J. Public Health
PD JAN
PY 2019
VL 31
IS 1
BP 18
EP 29
DI 10.1177/1010539518813704
PG 12
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA HK1SL
UT WOS:000457686700003
PM 30466293
DA 2025-06-11
ER

PT J
AU Hung, CI
   Liu, CY
   Hsiao, MC
   Yu, NW
   Chu, CL
AF Hung, Ching-I
   Liu, Chia-Yih
   Hsiao, Mei-Chun
   Yu, Nan-Wen
   Chu, Chun-Lin
TI Metabolic syndrome among psychiatric outpatients with mood and anxiety
   disorders
SO BMC PSYCHIATRY
LA English
DT Article
DE Bipolar disorder; Depression; Anxiety; Metabolic syndrome
ID BIPOLAR DISORDER; HOSPITAL ANXIETY; DEPRESSION; ASSOCIATION; PREVALENCE;
   COOCCURRENCE; SYMPTOMS; RISK
AB Background: Few studies have simultaneously compared the impacts of pharmacotherapy and mental diagnoses on metabolic syndrome (MetS) among psychiatric outpatients with mood and anxiety disorders. This study aimed to investigate the impacts of pharmacotherapy and mental diagnoses on MetS and the prevalence of MetS among these patients.
   Methods: Two-hundred and twenty-nine outpatients (men/women = 85/144) were enrolled from 1147 outpatients with mood and anxiety disorders by systematic sampling. Psychiatric disorders and MetS were diagnosed using the Structured Clinical Interview for DSM-IV-TR and the new International Diabetics Federation definition, respectively. The numbers of antipsychotics, mood stabilizers, and antidepressants being taken were recorded. Logistic regression was used to investigate the impacts of pharmacotherapy and psychiatric diagnoses on MetS.
   Results: Among 229 subjects, 51 (22.3%) fulfilled the criteria for MetS. The prevalence of MetS was highest in the bipolar I disorder (46.7%) patients, followed by bipolar II disorder (25.0%), major depressive disorder (22.0%), anxiety-only disorders (16.7%), and no mood and/or anxiety disorders (14.3%). The percentages of MetS among the five categories were correlated with those of the patients being treated with antipsychotics and mood stabilizers. Use of antipsychotics and/or mood stabilizers independently predicted a higher risk of MetS after controlling for demographic variables and psychiatric diagnoses. When adding body mass index (BMI) as an independent variable in the regression model, BMI became the most significant factor to predict MetS.
   Conclusion: BMI was found to be an important factor related to MetS. Pharmacotherapy might be one of underlying causes of elevated BMI. The interactions among MetS, BMI, pharmacotherapy, and psychiatric diagnoses might need further research.
C1 [Hung, Ching-I; Liu, Chia-Yih; Hsiao, Mei-Chun; Yu, Nan-Wen; Chu, Chun-Lin] Chang Gung Mem Hosp Linkou, Dept Psychiat, Taoyuan 333, Taiwan.
   [Hung, Ching-I; Liu, Chia-Yih; Hsiao, Mei-Chun] Chang Gung Univ, Sch Med, Taoyuan, Taiwan.
C3 Chang Gung Memorial Hospital; Chang Gung University
RP Liu, CY (corresponding author), Chang Gung Mem Hosp Linkou, Dept Psychiat, 5 Fu Shing St, Taoyuan 333, Taiwan.
EM Liucy752@cgmh.org.tw
FU National Science Council of Taiwan (NSC) [97-2314-B-182A-017-MY2]
FX This study was supported in part by a grant from the National Science
   Council of Taiwan (NSC 97-2314-B-182A-017-MY2). The funding source had
   no role in the design and conduct of the study; collection, analysis,
   and interpretation of the data; and preparation, review or approval of
   the manuscript.
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NR 38
TC 26
Z9 30
U1 0
U2 16
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-244X
J9 BMC PSYCHIATRY
JI BMC Psychiatry
PD JUN 21
PY 2014
VL 14
AR 185
DI 10.1186/1471-244X-14-185
PG 9
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA AK3HS
UT WOS:000338314700001
PM 24952586
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Vaccarino, V
   McClure, C
   Johnson, BD
   Sheps, DS
   Bittner, V
   Rutledge, T
   Shaw, LJ
   Sopko, G
   Olson, MB
   Krantz, DS
   Parashar, S
   Marroqui, OC
   Merz, CNB
AF Vaccarino, Viola
   McClure, Candace
   Johnson, B. Delia
   Sheps, David S.
   Bittner, Vera
   Rutledge, Thomas
   Shaw, Leslee J.
   Sopko, George
   Olson, Marian B.
   Krantz, David S.
   Parashar, Susmita
   Marroqui, Oscar C.
   Merz, C. Noel Bairey
TI Depression, the metabolic syndrome and cardiovascular risk
SO PSYCHOSOMATIC MEDICINE
LA English
DT Article
DE depression; cardiovascular disease; women; metabolic syndrome; obesity
ID SYNDROME EVALUATION WISE; CORONARY-ARTERY-DISEASE; INSULIN-RESISTANCE;
   HEART-DISEASE; YOUNG-ADULTS; WOMEN; MORTALITY; SYMPTOMS; ISCHEMIA;
   HISTORY
AB Background: The relationship between depression and the metabolic syndrome is unclear, and whether metabolic syndrome explains the association between depression and cardiovascular disease (CVD) risk is unknown. Methods: We studied 652 women who received coronary angiography as part of the Women's Ischemia Syndrome Evaluation (WISE) study and completed the Beck Depression Inventory (BDI). Women who had both elevated depressive symptoms (BD1 >= 10) and a previous diagnosis of depression were considered at highest risk, whereas those with one of the two conditions represented an intermediate group. The metabolic syndrome was defined according to the ATP-III criteria. The main outcome was incidence of adverse CVD events (hospitalizations for myocardial infarction, stroke, congestive heart failure, and CVD-related mortality) over a median follow-up of 5.9 years. Results: After adjusting for demographic factors, lifestyle and functional status, both depression categories were associated with about 60% increased odds for metabolic syndrome compared with no depression (p = .03). The number of metabolic syndrome risk factors increased gradually across the three depression categories (p = .003). During follow-up, 104 women (15.9%) experienced CVD events. In multivariable analysis, women with both elevated symptoms and a previous diagnosis of depression had 2.6 times higher risk of CVD. When metabolic syndrome was added to the model, the risk associated with depression only decreased by 7%, and both depression and metabolic syndrome remained significant predictors of CVD. Conclusions: In women with suspected coronary artery disease, the metabolic syndrome is independently associated with depression but explains only a small portion of the association between depression and incident CVD.
C1 [Vaccarino, Viola; Shaw, Leslee J.] Emory Univ, Sch Med, Dept Med, Div Cardiol, Atlanta, GA 30306 USA.
   [Parashar, Susmita] Emory Univ, Sch Med, Dept Med, Div Gen Med, Atlanta, GA USA.
   [McClure, Candace; Johnson, B. Delia; Olson, Marian B.] Univ Pittsburgh, Dept Epidemiol, Pittsburgh, PA 15261 USA.
   [Marroqui, Oscar C.] Univ Pittsburgh, Med Ctr, Cardiovasc Inst, Pittsburgh, PA USA.
   [Sheps, David S.] Univ Florida, Dept Med, Div Cardiovasc Med, Gainesville, FL USA.
   [Bittner, Vera] Univ Alabama Birmingham, Dept Med, Div Cardiovasc Dis, Birmingham, AL 35294 USA.
   [Rutledge, Thomas] Univ Calif San Diego, Dept Psychiat, San Diego, CA 92103 USA.
   [Sopko, George] NHLBI, NIH, Bethesda, MD 20892 USA.
   [Krantz, David S.] Uniformed Serv Univ Hlth Sci, Dept Med & Clin Psychol, Bethesda, MD 20814 USA.
   [Merz, C. Noel Bairey] Cedars Sinai Med Ctr, Cedars Sinai Res Inst, Dept Med, Div Cardiol, Los Angeles, CA 90048 USA.
C3 Emory University; Emory University; Pennsylvania Commonwealth System of
   Higher Education (PCSHE); University of Pittsburgh; Pennsylvania
   Commonwealth System of Higher Education (PCSHE); University of
   Pittsburgh; State University System of Florida; University of Florida;
   University of Alabama System; University of Alabama Birmingham;
   University of California System; University of California San Diego;
   National Institutes of Health (NIH) - USA; NIH National Heart Lung &
   Blood Institute (NHLBI); Uniformed Services University of the Health
   Sciences - USA; Cedars Sinai Medical Center
RP Vaccarino, V (corresponding author), Emory Univ, Sch Med, Dept Med, Div Cardiol, 1256 Briarcliff Rd NE,Suite-1 N, Atlanta, GA 30306 USA.
EM viola.vaccarino@emory.edu
RI Krantz, David/L-5364-2015; Vaccarino, Viola/AAW-5600-2020; Parashar,
   Susmita/GYJ-3885-2022; Marroquin, Oscar/F-2214-2015; Shaw,
   Leslee/ABG-4621-2022
OI Bittner, Vera/0000-0001-9456-850X; Vaccarino, Laura
   Viola/0000-0002-9054-0654; Krantz, David/0000-0002-1671-1355
FU NCRR NIH HHS [M01-RR00425] Funding Source: Medline; NHLBI NIH HHS
   [N01-HV-68161, N01-HV-68162, K24HL077506, N01-HV-68163, N01-HV-68164,
   R01-HL68630] Funding Source: Medline; NIA NIH HHS [R01 AG026255] Funding
   Source: Medline
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NR 40
TC 137
Z9 154
U1 0
U2 9
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0033-3174
EI 1534-7796
J9 PSYCHOSOM MED
JI Psychosom. Med.
PD JAN
PY 2008
VL 70
IS 1
BP 40
EP 48
DI 10.1097/PSY.0b013e31815c1b85
PG 9
WC Psychiatry; Psychology; Psychology, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry; Psychology
GA 253GM
UT WOS:000252506700007
PM 18158378
DA 2025-06-11
ER

PT J
AU Khuwaja, AK
   Lalani, S
   Dhanani, R
   Azam, IS
   Rafique, G
   White, F
AF Khuwaja, Ali Khan
   Lalani, Saima
   Dhanani, Raheem
   Azam, Iqbal Syed
   Rafique, Ghazala
   White, Franklin
TI Anxiety and depression among outpatients with type 2 diabetes: A
   multi-centre study of prevalence and associated factors
SO DIABETOLOGY & METABOLIC SYNDROME
LA English
DT Article
ID QUALITY-OF-LIFE; METABOLIC SYNDROME; RISK-FACTORS; COMORBID DEPRESSION;
   DISORDERS; ADULTS; HEALTH; COMPLICATIONS; POPULATION; ADHERENCE
AB Background: Anxiety and depression contribute to poor disease outcomes among individuals with diabetes. This study aimed to assess the prevalence of anxiety and depression and to identify their associated factors including metabolic components among people with type 2 diabetes.
   Methods: We conducted a cross-sectional, multi-center study in four out-patient clinics in Karachi, Pakistan. In all, 889 adults with type-2 diabetes were included in this study. Anxiety and depression were measured by using the Hospital Anxiety and Depression Scale (HADS). Multivariable analysis using multiple logistic regression was carried out to evaluate the combined effect of various factors associated with anxiety and depression, while adjusting for confounding variables.
   Results: Overall, 57.9% (95% CI = 54.7%, 61.2%) and 43.5% (95% CI = 40.3%, 46.8%) study participants had anxiety and depression respectively. Factors found to be independently associated with anxiety were physical inactivity, having hypertension and ischemic heart disease. For depression, being female, of older age, having hypertension and ischemic heart disease were significantly associated. Metabolic components found to be independently associated with both anxiety and depression were systolic blood pressure, fasting blood glucose and fasting blood triglycerides. Body mass index was independently associated with depression but not with anxiety.
   Conclusion: This study identified that a large proportion of adults with diabetes had anxiety and/or depression, and identified factors associated with these entities. These results alert clinicians to identify and treat anxiety and depression as common components of diabetes care. Additional studies are needed to establish the directional nature of this relationship and to test interventions.
C1 [Khuwaja, Ali Khan] Aga Khan Univ, Dept Family Med, Karachi 74880, Pakistan.
   [Lalani, Saima] Aga Khan Univ, Coll Med, Karachi 74880, Pakistan.
   [Dhanani, Raheem] Aga Khan Univ, Dept Family Med, Karachi, Pakistan.
   [Dhanani, Raheem] McGill Univ, Dept Family Med, Montreal, PQ H3A 2T5, Canada.
   [White, Franklin] Pacific Hlth & Dev Sci Inc, Victoria, BC, Canada.
   [White, Franklin] Dalhousie Univ, Halifax, NS, Canada.
C3 Aga Khan University; Aga Khan University; Aga Khan University; McGill
   University; Dalhousie University
RP Khuwaja, AK (corresponding author), Aga Khan Univ, Dept Family Med, Karachi 74880, Pakistan.
EM ali.khuwaja@aku.edu
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NR 39
TC 170
Z9 191
U1 0
U2 16
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1758-5996
J9 DIABETOL METAB SYNDR
JI Diabetol. Metab. Syndr.
PD DEC 20
PY 2010
VL 2
AR 72
DI 10.1186/1758-5996-2-72
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 759RC
UT WOS:000290265000002
PM 21171976
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Gans, ROB
AF Gans, Rijk O. B.
TI The metabolic syndrome, depression, and cardiovascular disease:
   Interrelated conditions that share pathophysiologic mechanisms
SO MEDICAL CLINICS OF NORTH AMERICA
LA English
DT Article
ID CORONARY-HEART-DISEASE; INDUCED MYOCARDIAL-ISCHEMIA; AUTONOMIC
   NERVOUS-SYSTEM; INSULIN-RESISTANCE; MENTAL STRESS; BLOOD-PRESSURE;
   RISK-FACTORS; ENDOTHELIAL DYSFUNCTION; CAROTID ATHEROSCLEROSIS;
   PLATELET-FUNCTION
AB This article introduces the metabolic syndrome as a clinical phenotype with consequences for diagnosis and treatment that go beyond the different clinical specialties involved. A life-course approach is suggested as a means of understanding the complex interrelations between the metabolic syndrome, depression, and cardiovascular disease. Pathophysiologic mechanisms that these conditions share are discussed in detail. These considerations provide arguments for a more integrative approach to patients in general that surpass the current disease-centered services such as endocrinology, psychiatry, and cardiology.
C1 Univ Groningen, Med Ctr, NL-9700 RB Groningen, Netherlands.
C3 University of Groningen
RP Gans, ROB (corresponding author), Univ Groningen, Med Ctr, Hanzepl 1, NL-9700 RB Groningen, Netherlands.
EM r.o.b.gans@int.umcg.nl
OI Gans, Reinold/0000-0001-5481-2387
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NR 97
TC 47
Z9 50
U1 1
U2 5
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0025-7125
EI 1557-9859
J9 MED CLIN N AM
JI Med. Clin. N. Am.
PD JUL
PY 2006
VL 90
IS 4
BP 573
EP +
DI 10.1016/j.mcna.2006.05.002
PG 20
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 071QB
UT WOS:000239615600005
PM 16843763
DA 2025-06-11
ER

PT J
AU Nover, CH
AF Nover, Cynthia Helen
TI Implementing a Mental Health and Primary Care Partnership Program in
   Placer County, California
SO SOCIAL WORK IN HEALTH CARE
LA English
DT Article
DE social support; cognitive behavior intervention; psychosocial
   intervention; primary care; social work; mental health
ID LIFE-STYLE; CARDIOVASCULAR RISK; COLLABORATIVE CARE; METABOLIC SYNDROME;
   LED INTERVENTION; CHRONIC ILLNESS; SCHIZOPHRENIA; DEPRESSION;
   MANAGEMENT; DISORDERS
AB Individuals with serious mental illness are at an increased risk for developing co-morbid chronic physical illnesses, such as diabetes and cardiovascular disease. This article is a descriptive piece about an intervention to decrease physical health risks in this population through a partnership effort between a primary care clinic and mental health agency in rural Placer County, California. The project was conducted as a part of the CalMEND Pilot Collaborative to Integrate Primary Care and Mental Health Services, which took place in five California counties in 2010-2011. A description of the program elements, conceptual models, key measures, and the process of program implementation is provided. Benefits were observed in areas of quality assurance, intra- and inter-agency teamwork, and access to adequate primary care for this population.
C1 Eastern Washington Univ, Sch Social Work, Cheney, WA 99004 USA.
C3 Eastern Washington University
RP Nover, CH (corresponding author), Eastern Washington Univ, Sch Social Work, Senior Hall, Cheney, WA 99004 USA.
EM research.cynthia@gmail.com
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NR 31
TC 3
Z9 5
U1 0
U2 10
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 0098-1389
EI 1541-034X
J9 SOC WORK HEALTH CARE
JI Soc. Work Health Care
PD FEB 7
PY 2014
VL 53
IS 2
BP 156
EP 182
DI 10.1080/00981389.2013.864378
PG 27
WC Social Work
WE Social Science Citation Index (SSCI)
SC Social Work
GA AC0PK
UT WOS:000332197000005
PM 24483334
DA 2025-06-11
ER

PT J
AU Wilson, CE
   Carpenter, JS
   Song, Y
   Ho, N
   Hickie, IB
AF Wilson, Chloe E.
   Carpenter, Joanne S.
   Song, Yun
   Ho, Nicholas
   Hickie, Ian B.
TI Associations between 24-h sleep-wake patterns and cardiometabolic risk
   factors in youth seeking mental health care
SO SLEEP AND BIOLOGICAL RHYTHMS
LA English
DT Article
DE Youth mental ill-health; Cardiometabolic risk factors; Sleep&#8211; wake
   patterns; Actigraphy; Psychopathology
AB One hundred and eleven youth with mental ill-health underwent systematic clinical, laboratory and actigraphy monitoring to report associations between 24-h sleep-wake patterns and cardiometabolic risk factors. Multiple linear regression analyses, controlling for medication usage and class, age and sex, found significant associations between: later sleep onset and BMI; standard variation (SV) in the sleep offset with both insulin values and the updated homeostatic model assessment of insulin resistance (HOMA2-IR) values; and the SV of the sleep midpoint with both poorer fasting insulin, and HOMA2-IR values. Further longitudinal research is required to determine the causative relationships between 24-h sleep-wake cycle patterns, and cardiometabolic outcomes.
C1 [Wilson, Chloe E.; Carpenter, Joanne S.; Song, Yun; Ho, Nicholas; Hickie, Ian B.] Univ Sydney, Brain & Mind Ctr, Youth Mental Hlth Team, Sydney, NSW, Australia.
C3 University of Sydney
RP Wilson, CE (corresponding author), Univ Sydney, Brain & Mind Ctr, Youth Mental Hlth Team, Sydney, NSW, Australia.
EM chloe.wilson@sydney.edu.au
RI Carpenter, Joanne/HZK-3629-2023; Hickie, Ian/K-8975-2015
OI Hickie, Ian/0000-0001-8832-9895; Ho, Nicholas/0000-0001-9843-0866
FU National Health and Medical Research Council Australia Fellowship
   [511921]; Liu McCabe Family Scholarship; Caroline Quinn Research Grant
FX This study was partially funded by a philanthropic gift (The Liu McCabe
   Family Scholarship awarded to C.E.W), a National Health and Medical
   Research Council Australia Fellowship (No. 511921, awarded to I.B.H) and
   a philanthropic gift (the Caroline Quinn Research Grant awarded to
   J.S.C). The funders of this study had no involvement in the: study
   design; collection, analysis and reporting of the data; writing of the
   report; or decision to submit the paper for publication.
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NR 10
TC 1
Z9 1
U1 0
U2 0
PU SPRINGER JAPAN KK
PI TOKYO
PA SHIROYAMA TRUST TOWER 5F, 4-3-1 TORANOMON, MINATO-KU, TOKYO, 105-6005,
   JAPAN
SN 1446-9235
EI 1479-8425
J9 SLEEP BIOL RHYTHMS
JI Sleep Biol. Rhythms
PD JUL
PY 2021
VL 19
IS 3
BP 337
EP 340
DI 10.1007/s41105-021-00314-z
EA FEB 2021
PG 4
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA SW4NN
UT WOS:000617812800001
DA 2025-06-11
ER

PT J
AU Camacho, A
AF Camacho, Alvaro
TI Is anxious-depression an inflammatory state?
SO MEDICAL HYPOTHESES
LA English
DT Article
ID CORONARY-HEART-DISEASE; CORTICOTROPIN-RELEASING-FACTOR;
   CARDIOVASCULAR-DISEASE; MAJOR DEPRESSION; PLASMINOGEN-ACTIVATOR;
   MYOCARDIAL-INFARCTION; POSTMENOPAUSAL WOMEN; METABOLIC SYNDROME; ANXIETY
   SYMPTOMS; RISK-FACTORS
AB For several years, the literature has examined the association of depression and anxiety with inflammatory states such as atherosclerosis and cardiovascular disease, yet this association remains inconclusive. Several possible immune and endocrinological pathways have been postulated that associate depression and anxiety with inflammation and immune dysregulation. Anxiety and depression have usually been envisioned as two separate psychiatric conditions yet they share similar symptoms and are frequently encountered together among individuals. Individuals suffering from anxious-depression are more refractory to treatment and have been reported to have greater disability compared to individuals with anxiety or depression alone. With the current changes in the diagnostic manual for psychiatric disorders placing more emphasis on a dimensional approach for the diagnosis of psychiatric illnesses, the hypothesis presented is that anxious-depression should be considered as a chronic inflammatory phenomenon since it shares common physiopathological pathways and pharmacological treatments with inflammatory states. This hypothesis might help to investigate how different levels of inflammatory biomarkers could be correlated with symptoms of anxious-depression. (C) 2013 Elsevier Ltd. All rights reserved.
C1 [Camacho, Alvaro] Univ Calif San Diego, Dept Family & Prevent Med, San Diego, CA 92251 USA.
   [Camacho, Alvaro] Univ Calif San Diego, Dept Psychiat, San Diego, CA 92251 USA.
C3 University of California System; University of California San Diego;
   University of California System; University of California San Diego
RP Camacho, A (corresponding author), Univ Calif San Diego, Dept Family & Prevent Med, 2417 Marshall Ave Ste 1, San Diego, CA 92251 USA.
EM acamacho@ucsd.edu
FU National Heart Lung and Blood Institute, National Institute of Health,
   United States of America [T32HL079891]
FX The author has special gratitude to Joel E. Dimsdale, MD for his years
   of mentorship and support for this manuscript. Also special thanks to
   Matthew A. Allison, MD, MPH and Murray Stein, MD, MPH for their valuable
   feedback. This work was supported by training grant T32HL079891 from the
   National Heart Lung and Blood Institute, National Institute of Health,
   United States of America.
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NR 75
TC 34
Z9 37
U1 0
U2 6
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0306-9877
EI 1532-2777
J9 MED HYPOTHESES
JI Med. Hypotheses
PD OCT
PY 2013
VL 81
IS 4
BP 577
EP 581
DI 10.1016/j.mehy.2013.07.006
PG 5
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 243ZO
UT WOS:000326357100015
PM 23891039
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Song, J
   Kwon, N
   Lee, MH
   Ko, YG
   Lee, JH
   Kim, OY
AF Song, Juhyun
   Kwon, Nayeon
   Lee, Mi-Hyang
   Ko, Young-Guk
   Lee, Jong Ho
   Kim, Oh Yoen
TI Association of serum phospholipid PUFAs with cardiometabolic risk:
   Beneficial effect of DHA on the suppression of vascular
   proliferation/inflammation
SO CLINICAL BIOCHEMISTRY
LA English
DT Article
DE Cardiometabolic risk; Polyunsaturated fatty acids; Docosahexaenoic acid;
   Vascular proliferation; MAPK pathways; Nuclear factor-kappa B p65
   nuclear translocation
ID FATTY-ACID-COMPOSITION; SMOOTH-MUSCLE-CELLS; MIDDLE-AGED MEN;
   DOCOSAHEXAENOIC ACID; DIETARY-FAT; CARDIOVASCULAR MORTALITY; PLASMA;
   P38; MACROPHAGES; INDUCTION
AB Objectives: Blood or dietary polyunsaturated fatty acids (PUFAs), particularly omega 3-PUFAs were known for cardiovascular protective effect. However, the results are still controversial. We aimed to investigate the association of serum phospholipid PUFAs with cardiometabolic risk through cross-sectional/experimental studies.
   Design/methods: Serum phospholipid FA compositions and cardiometabolic risk parameters were measured in controls [healthy: n = 987, metabolic syndrome (MetS): n = 214] and CAD patients (CAD-only: n = 152, CAD + MetS: n = 56). Experimental assays were performed in vascular smooth muscle cells (VSMCs).
   Results: Major cardiometabolic risk markers, i.e. insulin resistance, hs-C-reactive proteins, and malondialdehyde were higher, and adiponectin and LDL particle size were lower in CAD patients, particularly those with MetS than in healthy controls. Serum linoleic acid (LA, C18: 2 omega-6) was lowest and dihomo-gamma-linolenic acids (DGLAs, C20: 3 omega-6) were highest in CAD patients with MetS among the 4 groups. Docosahexaenoic acid (DHA, C22: 6 omega-3) was lower and arachidonic acid (AA, C20: 4 omega-6) and omega 6/omega 3-PUFAs were higher in CAD patients than in controls. omega 3-PUFAs were significantly lower in CAD patients, particularly those with MetS than in healthy controls. Multiple regression analysis revealed that AA and DHA among serum FAs were mainly associated with the cardiometabolic risk (beta'-coefficients for AA:0.336; DHA: -0.296) together with age, MetS factors, LA, DGLA and gender (r = 0.529, p < 0.001). Under LPS-induced stress condition, LA and DHA significantly suppressed VSMC proliferation. DHA also up-regulated the phosphorylation of p38 and ERK, and dramatically inhibited nuclear translocation of NF-kappa B-p65 in VSMCs.
   Conclusion: AA and DHA were mainly associated with cardiometabolic risk. Particularly, DHA may be effective on suppression of vascular proliferation and inflammation. (C) 2014 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
C1 [Song, Juhyun] Yonsei Univ, Interdisciplinary Course Sci Aging, Seoul 120749, South Korea.
   [Kwon, Nayeon; Lee, Mi-Hyang; Lee, Jong Ho] Yonsei Univ, Dept Food & Nutr, Seoul 120749, South Korea.
   [Ko, Young-Guk] Yonsei Univ Hlth Syst, Severance Cardiovasc Hosp, Div Cardiol, Seoul, South Korea.
   [Kim, Oh Yoen] Dong A Univ, Dept Food Sci & Nutr, Pusan 604020, South Korea.
C3 Yonsei University; Yonsei University; Yonsei University; Yonsei
   University Health System; Dong A University
RP Lee, JH (corresponding author), Yonsei Univ, Dept Food & Nutr, Seoul 120749, South Korea.
EM jhleeb@yonsei.ac.kr; oykim@dau.ac.kr
RI Kim, Oh/AAA-6492-2022; Song, Juhyun/AAH-3162-2020
OI Ko, Young-Guk/0000-0001-7748-5788; Song, Juhyun/0000-0002-9165-8507
FU Basic Science Research Program through the National Research Foundation
   of Korea (NRF); Ministry of Science, ICT and Future Planning
   [2013R1A1A3011535]; Brain Busan 21 project
FX We thank the research volunteers who participated in the studies
   described in this manuscript. This study was supported by Basic Science
   Research Program through the National Research Foundation of Korea (NRF)
   funded by the Ministry of Science, ICT and Future Planning
   (2013R1A1A3011535) and Brain Busan 21 project.
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NR 41
TC 15
Z9 16
U1 0
U2 14
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0009-9120
EI 1873-2933
J9 CLIN BIOCHEM
JI Clin. Biochem.
PD APR
PY 2014
VL 47
IS 6
BP 361
EP 368
DI 10.1016/j.clinbiochem.2014.01.005
PG 8
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA AE1WP
UT WOS:000333763300008
PM 24457065
DA 2025-06-11
ER

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   Saw, Jo Anne
   Saygili, Gorkem
   Schneidereit, Patricia
   Shah, Bhumika
   Shirasaka, Tomohiro
   Silagadze, Ketevan
   Sitanggang, Satti
   Skugarevsky, Oleg
   Spikina, Anna
   Mahalingappa, Sridevi Sira
   Stoyanova, Maria
   Szczegielniak, Anna
   Tamasan, Simona Claudia
   Tavormina, Giuseppe
   Tavormina, Maurilio Giuseppe Maria
   Theodorakis, Pavlos N.
   Tohen, Mauricio
   Tsapakis, Eva Maria
   Tukhvatullina, Dina
   Ullah, Irfan
   Vaidya, Ratnaraj
   Vega-Dienstmaier, Johann M.
   Vrublevska, Jelena
   Vukovic, Olivera
   Vysotska, Olga
   Widiasih, Natalia
   Yashikhina, Anna
   Prezerakos, Panagiotis E.
   Smirnova, Daria
TI Somatic multicomorbidity and disability in patients with psychiatric
   disorders in comparison to the general population: a
   quasi-epidemiological investigation in 54,826 subjects from 40 countries
   (COMET-G study)
SO CNS SPECTRUMS
LA English
DT Article
DE Epidemiology; multicomorbidity; disability; premature death;
   somatic-mental comorbidity
ID SERIOUS MENTAL-ILLNESS; SUICIDE ATTEMPTS; GLOBAL BURDEN; RISK-FACTORS;
   MULTIMORBIDITY PATTERNS; EXCESS MORTALITY; PREVALENCE; HEALTH; DISEASE;
   COMORBIDITY
AB Background The prevalence of medical illnesses is high among patients with psychiatric disorders. The current study aimed to investigate multi-comorbidity in patients with psychiatric disorders in comparison to the general population. Secondary aims were to investigate factors associated with metabolic syndrome and treatment appropriateness of mental disorders.Methods The sample included 54,826 subjects (64.73% females; 34.15% males; 1.11% nonbinary gender) from 40 countries (COMET-G study). The analysis was based on the registration of previous history that could serve as a fair approximation for the lifetime prevalence of various medical conditions.Results About 24.5% reported a history of somatic and 26.14% of mental disorders. Mental disorders were by far the most prevalent group of medical conditions. Comorbidity of any somatic with any mental disorder was reported by 8.21%. One-third to almost two-thirds of somatic patients were also suffering from a mental disorder depending on the severity and multicomorbidity. Bipolar and psychotic patients and to a lesser extent depressives, manifested an earlier (15-20 years) manifestation of somatic multicomorbidity, severe disability, and probably earlier death. The overwhelming majority of patients with mental disorders were not receiving treatment or were being treated in a way that was not recommended. Antipsychotics and antidepressants were not related to the development of metabolic syndrome.Conclusions The finding that one-third to almost two-thirds of somatic patients also suffered from a mental disorder strongly suggests that psychiatry is the field with the most trans-specialty and interdisciplinary value and application points to the importance of teaching psychiatry and mental health in medical schools and also to the need for more technocratically oriented training of psychiatric residents.
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C3 Aristotle University of Thessaloniki; Manchester Metropolitan
   University; University of Munich; Universidad Peruana Cayetano Heredia;
   Mayo Clinic; Shinshu University; Bayero University; Deakin University;
   Barwon Health; Florey Institute of Neuroscience & Mental Health; Orygen,
   The National Centre of Excellence in Youth Mental Health; University of
   Melbourne; University of Melbourne; University of Zagreb; UNIVERSITY
   ZAGREB HOSPITAL; University of Oviedo; Central University Hospital
   Asturias; Instituto de Investigacion Sanitaria del Principado de
   Asturias (ISPA); CIBER - Centro de Investigacion Biomedica en Red;
   CIBERSAM; University of Oviedo; Victor Babes University of Medicine &
   Pharmacy, Timisoara; Vilnius University; Johnson & Johnson; Johnson &
   Johnson USA; Centro Nacional Patagonico (CENPAT); Consejo Nacional de
   Investigaciones Cientificas y Tecnicas (CONICET); University of Buenos
   Aires; Universidad Peruana Cayetano Heredia; University of L'Aquila; G
   d'Annunzio University of Chieti-Pescara; Universidad de Chile;
   Universidade Federal do Ceara; University of L'Aquila; Barwon Health;
   Geelong Hospital; Semmelweis University; University of Indonesia;
   Diskapi Yildirim Beyazit Training & Research Hospital; Maastricht
   University; University of Buenos Aires; Queens University - Canada;
   Ryazan State Medical University; Medical University Sofia; Bogomolets
   National Medical University; Kyrgyz State Medical Academy; Ministry of
   Health - Kyrgyzstan; Instituto Nacional de Psiquiatria Ramon de la
   Fuente Muniz; University of California System; University of California
   San Diego; University Diego Portales; Medical University Sofia; Tel Aviv
   University; University of Tsukuba; University of Liverpool; Universiti
   Teknologi MARA; Jahangirnagar University; Medical University Sofia;
   Egyptian Knowledge Bank (EKB); Ain Shams University; Queens University -
   Canada; Universiti Teknologi MARA; New York Medical College; University
   of Zagreb; University of Birmingham; University of Warwick; City
   Hospital Ankara; Lund University; Samara State Medical University;
   Odessa National Medical University; University of West Attica;
   Sher-i-Kashmir Institute of Medical Sciences; University of Sargodha;
   Ministry of Education of Azerbaijan Republic; Azerbaijan Medical
   University; University of Pisa; Dow University of Health Sciences; Dow
   Medical College; Universidad Nacional Autonoma de Honduras; Pirogov
   Russian National Research Medical University; Ahmadu Bello University;
   Tel Aviv University; Sackler Faculty of Medicine; Kyrgyz-Russian Slavic
   University; Hellenic Open University; University of Belgrade; South
   London & Maudsley NHS Trust; University of London; King's College
   London; Universidade do Porto; Tel Aviv University; Riga Stradins
   University; Universidad Nacional Autonoma de Honduras; Universidad de
   San Martin de Porres; Universidad Anahuac; Tecnologico de Monterrey;
   Tilburg University; Belarusian State Medical University; University of
   Nottingham; Medical University of Silesia; University of Cambridge;
   World Health Organization; University of New Mexico; Aristotle
   University of Thessaloniki; University of London; Queen Mary University
   London; Newcastle University - UK; Universidad Peruana Cayetano Heredia;
   Riga Stradins University; Bogomolets National Medical University; Samara
   State Medical University; University of Peloponnese
RP Karakatsoulis, GN (corresponding author), Aristotle Univ Thessaloniki Greece, Sch Med, Dept Psychiat 3, Thessaloniki, Greece.
EM gregkarakatsoulis@gmail.com
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NR 72
TC 1
Z9 1
U1 2
U2 16
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 1092-8529
EI 2165-6509
J9 CNS SPECTRUMS
JI CNS Spectr.
PD APR
PY 2024
VL 29
IS 2
BP 126
EP 149
DI 10.1017/S1092852924000026
EA JAN 2024
PG 24
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Psychiatry
GA NK3B5
UT WOS:001164582600001
PM 38269574
DA 2025-06-11
ER

PT J
AU Kinder, LS
   Carnethon, MR
   Palaniappan, LP
   King, AC
   Fortmann, SP
AF Kinder, LS
   Carnethon, MR
   Palaniappan, LP
   King, AC
   Fortmann, SP
TI Depression and the metabolic syndrome in young adults: Findings from the
   third national health and nutrition examination survey
SO PSYCHOSOMATIC MEDICINE
LA English
DT Article
DE depression; the metabolic syndrome; the third national health and
   nutrition examination survey
ID HEART-RATE-VARIABILITY; CARDIOVASCULAR-DISEASE; PSYCHOLOGICAL-FACTORS;
   MORTALITY; PREVALENCE; ASSOCIATION; RISK; SYMPTOMATOLOGY; PATHOGENESIS;
   POPULATION
AB Objective: Previous reports have suggested that depression may lead to the development of cardiovascular disease through its association with the metabolic syndrome; however, little is known about the relationship between depression and the metabolic syndrome. The aim of this study was to establish an association between depression and the metabolic syndrome in a nationally representative sample. Methods: The Third National Health and Nutrition Examination Survey is a population-based health survey of noninstitutionalized US citizens completed between 1988 and 1994. Three thousand one hundred eighty-six men and 3003 women, age 17 to 39, free of coronary heart disease and diabetes, completed the depression module from the Diagnostic Interview Schedule and a medical examination that provided clinical data needed to establish the presence of the metabolic syndrome, as defined by the Third Report of the National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Cholesterol in Adults. Results: Women with a history of a major depressive episode were twice as likely to have the metabolic syndrome compared with those with no history of depression. The relationship between depression and metabolic syndrome remained after controlling for age, race, education, smoking, physical inactivity, carbohydrate consumption, and alcohol use. Men with a history of depression were not significantly more likely to have the metabolic syndrome. Conclusions: The prevalence of the metabolic syndrome is elevated among women with a history of depression. It is important to better understand the role depression may play in the effort to reduce the prevalence of the metabolic syndrome and its health consequences.
C1 Stanford Univ, Sch Med, Stanford Ctr Res Dis Prevent, Stanford, CA USA.
C3 Stanford University
RP VA Puget Hlth Care Syst, 1660 S Columbian Way, Seattle, WA 98108 USA.
EM lskinder@stanfordalumni.org
OI Palaniappan, Latha/0000-0002-1245-665X; King, Abby/0000-0002-7949-8811
FU NHLBI NIH HHS [5 T32 HL 07034, F32 HL 10338] Funding Source: Medline
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NR 41
TC 270
Z9 310
U1 0
U2 17
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0033-3174
EI 1534-7796
J9 PSYCHOSOM MED
JI Psychosom. Med.
PD MAY-JUN
PY 2004
VL 66
IS 3
BP 316
EP 322
DI 10.1097/01.psy.0000124755.91880.f4
PG 7
WC Psychiatry; Psychology; Psychology, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry; Psychology
GA 822OA
UT WOS:000221548300005
PM 15184689
DA 2025-06-11
ER

PT J
AU van Leijden, MJ
   Penninx, BWJH
   Agyemang, C
   Olff, M
   Adriaanse, MC
   Snijder, MB
AF van Leijden, Marieke J.
   Penninx, Brenda W. J. H.
   Agyemang, Charles
   Olff, Miranda
   Adriaanse, Marcel C.
   Snijder, Marieke B.
TI The association of depression and posttraumatic stress disorder with the
   metabolic syndrome in a multi-ethnic cohort: the HELIUS study
SO SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY
LA English
DT Article
DE Metabolic syndrome; Depression; Posttraumatic stress disorder;
   Ethnicity; HELIUS study
ID PERCEIVED ETHNIC DISCRIMINATION; CORONARY-HEART-DISEASE; CARDIOVASCULAR
   MORTALITY; GENERALIZED ANXIETY; MINORITY-GROUPS; RISK-FACTORS; HEALTH;
   PTSD; PREVALENCE; SYMPTOMS
AB Purpose Depression and posttraumatic stress disorder (PTSD) may be linked to the metabolic syndrome (MetS). Consistency of this association across ethnic groups and the influence of comorbidity of depression/PTSD were examined.
   Methods Cross-sectional baseline data from the HELIUS study were used (4527 Dutch, 2999 South-Asian Surinamese, 4058 African Surinamese, 2251 Ghanaian, 3522 Turkish and 3825 Moroccan participants). The Patient Health Questionnaire-9 (PHQ-9) (score range 0-27) measured depressive symptoms. A 9-item questionnaire (score range 0-9) measured PTSD symptoms. The MetS was defined according to the International Diabetes Federation. The association of a depressed mood (PHQ-9 sum score >= 10) and severe PTSD symptoms (sum score >= 7) with the MetS was examined using logistic regression. Interaction with ethnicity and between a depressed mood and severe PTSD symptoms was tested.
   Results A depressed mood was associated with the MetS [OR (95% CI) = 1.37 (1.24-1.51)] in the total sample and consistent across ethnic groups (p values for interaction all > 0.05). Severe PTSD symptoms were significantly associated with the MetS in the Dutch [OR (95% CI) = 1.71 (1.07-2.73)]. The South-Asian Surinamese, Turks and Moroccans showed weaker associations than the Dutch (p values for interaction all < 0.05). A depressed mood and severe PTSD symptoms did not interact in the association with the MetS (p values for interaction > 0.05).
   Conclusions A depressed mood was consistently associated with the MetS across ethnic groups, but the association between severe PTSD symptoms and the MetS maybe ethnicity dependent. The association with the MetS was not different in case of depressed mood/severe PTSD symptoms comorbidity.
C1 [van Leijden, Marieke J.; Agyemang, Charles; Snijder, Marieke B.] Acad Med Ctr, Dept Publ Hlth, Meibergdreef 15, NL-1105 AZ Amsterdam, Netherlands.
   [Penninx, Brenda W. J. H.] Vrije Univ Amsterdam Med Ctr, Dept Psychiat, Amsterdam Publ Hlth Res Inst, Oldenaller 1, NL-1081 HL Amsterdam, Netherlands.
   [Olff, Miranda] Acad Med Ctr, Dept Psychiat, Meibergdreef 5, NL-1105 AZ Amsterdam, Netherlands.
   [Adriaanse, Marcel C.] Vrije Univ Amsterdam, Dept Hlth Sci, De Boelelaan 1085, NL-1081 HV Amsterdam, Netherlands.
C3 University of Amsterdam; Academic Medical Center Amsterdam; Vrije
   Universiteit Amsterdam; VU UNIVERSITY MEDICAL CENTER; Vrije Universiteit
   Amsterdam
RP van Leijden, MJ (corresponding author), Acad Med Ctr, Dept Publ Hlth, Meibergdreef 15, NL-1105 AZ Amsterdam, Netherlands.
EM mariekevanleijden.amc@gmail.com
RI Olff, Miranda/S-6235-2019; Adriaanse, Marieke/AFQ-8371-2022; Penninx,
   Brenda WJH/S-7627-2017
OI Olff, Miranda/0000-0003-1016-9515; Penninx, Brenda
   WJH/0000-0001-7779-9672; Adriaanse, Marcel/0000-0002-5085-6662
FU Dutch Heart Foundation [2010T084]; Netherlands Organization for Health
   Research and Development (ZonMw) [200500003]; European Union (FP-7)
   [278901]; European Fund for the Integration of non-EU immigrants (EIF)
   [2013EIF013]
FX The HELIUS study is conducted by the Academic Medical Center Amsterdam
   and the Public Health Service of Amsterdam. Both organizations provided
   core support for HELIUS. The HELIUS study is also funded by the Dutch
   Heart Foundation (2010T084), the Netherlands Organization for Health
   Research and Development (ZonMw) (200500003), the European Union (FP-7)
   (278901), and the European Fund for the Integration of non-EU immigrants
   (EIF) (2013EIF013). We acknowledge the AMC Biobank for their support in
   biobank management and high-quality storage of collected samples. We are
   most grateful to the participants of the HELIUS study and the management
   team, research nurses, interviewers, research assistants and other staff
   who have taken part in gathering the data of this study.
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NR 63
TC 8
Z9 8
U1 0
U2 7
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0933-7954
EI 1433-9285
J9 SOC PSYCH PSYCH EPID
JI Soc. Psychiatry Psychiatr. Epidemiol.
PD SEP
PY 2018
VL 53
IS 9
BP 921
EP 930
DI 10.1007/s00127-018-1533-y
PG 10
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA HE2IK
UT WOS:000453099900006
PM 29796849
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU García-Rivera, BR
   Olguín-Tiznado, JE
   Aranibar, MF
   Ramírez-Barón, MC
   Camargo-Wilson, C
   López-Barreras, JA
   García-Alcaraz, JL
AF Rosa Garcia-Rivera, Blanca
   Everardo Olguin-Tiznado, Jesus
   Fernanda Aranibar, Monica
   Concepcion Ramirez-Baron, Maria
   Camargo-Wilson, Claudia
   Andres Lopez-Barreras, Juan
   Luis Garcia-Alcaraz, Jorge
TI Burnout Syndrome in Police Officers and Its Relationship with Physical
   and Leisure Activities
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Article
DE burnout syndrome; fatigue; psychosocial risk factors; work-related
   exhaustion; police
ID METABOLIC SYNDROME; MENTAL-HEALTH; OUT SYNDROME; STRESS; INVENTORY;
   INTERVENTIONS; CONSEQUENCES; PREDICTORS; DEPRESSION; EDUCATION
AB No previous studies in Mexico have been found that jointly analyze physical and leisure activities as variables related to mental health in police officers. This paper presents research on burnout in Mexican Police officers. The question it answers is: is there any association of burnout with physical and leisure activities and personal profile? A total of 276 police officers (87% men and 13% women) participated. To obtain information, the Spanish Burnout Inventory and the Operational Police Stress questionnaires were used. A cross sectional study design was utilized with tests of validity and reliability, goodness of fit, analysis of variance (ANOVA), and analysis of k-means clusters. Results showed that a high number of policemen had high prevalence of burnout and a high level of mental exhaustion, and that exercise was positively and significantly related to lower burnout risk. Men showed higher risk than women. Results should be considered to improve interventions and occupational health practices in the police force. This paper improves understanding of burnout among policemen and the importance of exercise and leisure activities to alleviate burnout.
C1 [Rosa Garcia-Rivera, Blanca; Fernanda Aranibar, Monica; Concepcion Ramirez-Baron, Maria] Autonomous Univ Baja California, Fac Adm & Social Sci, Ensenada 22890, BC, Mexico.
   [Everardo Olguin-Tiznado, Jesus; Camargo-Wilson, Claudia] Autonomous Univ Baja California, Fac Engn Architecture & Design, Ensenada 22860, BC, Mexico.
   [Andres Lopez-Barreras, Juan] Autonomous Univ Baja California, Fac Chem Sci & Engn, Tijuana 20631, BC, Mexico.
   [Luis Garcia-Alcaraz, Jorge] Autonomous Univ Ciudad Juarez, Dept Ind Engn & Mfg, Ciudad Juarez 32310, CHI, Mexico.
C3 Universidad Autonoma de Baja California; Universidad Autonoma de Baja
   California; Universidad Autonoma de Baja California; Universidad
   Autonoma de Ciudad Juarez
RP García-Alcaraz, JL (corresponding author), Autonomous Univ Ciudad Juarez, Dept Ind Engn & Mfg, Ciudad Juarez 32310, CHI, Mexico.
EM blanca_garcia@uabc.edu.mx; jeo179@uabc.edu.mx; maranibar@uabc.edu.mx;
   cony@uabc.edu.mx; ccamargo@uabc.edu.mx; jalopez@uabc.edu.mx;
   jorge.garcia@uacj.mx
RI Tiznado, Jesús/AAW-2674-2020; Garcia-Alcaraz, Jorge Luis/N-9124-2013
OI Garcia-Alcaraz, Jorge Luis/0000-0002-7092-6963; CAMARGO WILSON,
   CLAUDIA/0000-0001-9102-3694; Lopez-Barreras, Juan
   Andres/0000-0002-5477-033X; Garcia-Rivera, Blanca
   Rosa/0000-0003-3114-4114; Olguin Tiznado, Jesus
   Everardo/0000-0002-6205-0973
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NR 74
TC 21
Z9 25
U1 2
U2 25
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD AUG
PY 2020
VL 17
IS 15
AR 5586
DI 10.3390/ijerph17155586
PG 17
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA NL2NL
UT WOS:000567258600001
PM 32756344
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Fond, G
   Godin, O
   Schürhoff, F
   Berna, F
   Bulzacka, E
   Andrianarisoa, M
   Brunel, L
   Aouizerate, B
   Capdevielle, D
   Chereau, I
   Coulon, N
   D'Amato, T
   Dubertret, C
   Dubreucq, J
   Faget, C
   Lançon, C
   Leignier, S
   Mallet, J
   Misdrahi, D
   Passerieux, C
   Rey, R
   Schandrin, A
   Urbach, M
   Vidailhet, P
   Leboyer, M
   Boyer, L
   Llorca, PM
AF Fond, G.
   Godin, O.
   Schurhoff, F.
   Berna, F.
   Bulzacka, E.
   Andrianarisoa, M.
   Brunel, L.
   Aouizerate, B.
   Capdevielle, D.
   Chereau, I.
   Coulon, N.
   D'Amato, T.
   Dubertret, C.
   Dubreucq, J.
   Faget, C.
   Lancon, C.
   Leignier, S.
   Mallet, J.
   Misdrahi, D.
   Passerieux, C.
   Rey, R.
   Schandrin, A.
   Urbach, M.
   Vidailhet, P.
   Leboyer, M.
   Boyer, L.
   Llorca, P. M.
CA FACE-SZ FondaMental Acad Ctr Exper
TI Hypovitaminosis D is associated with depression and anxiety in
   schizophrenia: Results from the national FACE-SZ cohort
SO PSYCHIATRY RESEARCH
LA English
DT Article
DE Vitamin D; Schizophrenia; Depression; Anxiety; Metabolic syndrome
ID LOW VITAMIN-D; PREMORBID INTELLIGENCE LEVELS; METABOLIC SYNDROME; D
   SUPPLEMENTATION; D DEFICIENCY; DISORDERS; SYMPTOMS; INFLAMMATION;
   RELIABILITY; PREVALENCE
AB Objective: Hypovitaminosis D has been associated with respectively major depressive disorder, schizophrenia (SZ) and cognitive disorders in the general population, and with positive and negative symptoms and metabolic syndrome in schizophrenia. The objectives were (i) to determine the prevalence of hypovitaminosis D and associated factors (with a focus on depression and cognition) in a national non-selected multicentric sample of community-dwelling SZ subjects (ii) to determine the rate of SZ patients being administered vitamin D supplementation and associated factors.
   Methods: A comprehensive 2 daylong clinical and neuropsychological battery was administered in 140 SZ subjects included between 2015 and 2017 in the national FondaMental Expert Center (FACE-SZ) Cohort. Hypovitaminosis D was defined by blood vitamin D level <25 nM. Depressive symptoms were assessed by the Positive and Negative Syndrome Scale depressive subscore and current anxiety disorder by the Structured Clinical Interview for Mental Disorders.
   Results: Hypovitaminosis D has been found in 21.4% of the subjects and none of them had received vitamin D supplementation in the previous 12 months. In multivariate analysis, hypovitaminosis D has been significantly associated with respectively higher depressive symptoms (aOR = 1.18 [1.03-1.35], p = 0.02) and current anxiety disorder (aOR = 6.18 [2.15-17.75], p = 0.001), independently of age and gender. No association of hypovitaminosis D with respectively positive and negative symptoms, cognitive scores or other biological variables has been found (all p > 0.05), however, a trend toward significance has been found for metabolic syndrome (p = 0.06). Vitamin D supplementation has been administered during the previous 12 months in only 8.5% of the subjects but was associated with lower depressive symptoms (aOR = 0.67 [0.46-0.98], p = 0.04) and lower rate of current anxiety disorder (aOR = 0.06 [0.01-0.66],p = 0.02) compared to patients with hypovitaminosis D.
   Conclusion: Hypovitaminosis D is frequent and associated with depressive symptoms and anxiety disorders in schizophrenia. Vitamin D supplementation is associated with lower depressive and anxiety symptoms, however patients with hypovitaminosis D remain insufficiently treated.
C1 [Fond, G.; Godin, O.; Schurhoff, F.; Berna, F.; Bulzacka, E.; Andrianarisoa, M.; Brunel, L.; Aouizerate, B.; Capdevielle, D.; Chereau, I.; Coulon, N.; D'Amato, T.; Dubertret, C.; Dubreucq, J.; Faget, C.; Lancon, C.; Leignier, S.; Mallet, J.; Misdrahi, D.; Passerieux, C.; Rey, R.; Schandrin, A.; Urbach, M.; Leboyer, M.; Boyer, L.; Llorca, P. M.] Fdn FondaMental, Creteil, France.
   [Schurhoff, F.; Bulzacka, E.; Andrianarisoa, M.; Brunel, L.; Coulon, N.; Leboyer, M.] Univ Paris Est Creteil, Pole Psychiat Hop Univ H Mondor, DHU Pe PSY, INSERM U955,Equipe Psychiat Translat, Creteil, France.
   [Fond, G.; Faget, C.; Lancon, C.; Boyer, L.] Aix Marseille Univ, Fac Med, Sect Timone, AP HM,EA 3279,CEReSS Ctr Etud & Rech Serv Sante &, 27 Blvd Jean Moulin, F-13005 Marseille, France.
   [Aouizerate, B.; Misdrahi, D.] Univ Bordeaux, Ctr Hosp Charles Perrens, F-33076 Bordeaux, France.
   [Berna, F.; Vidailhet, P.] Univ Strasbourg, Hop Univ Strasbourg, INSERM U1114, Federat Med Translat Strasbourg, Strasbourg, France.
   [Capdevielle, D.; Schandrin, A.] Univ Montpellier I, CHRU Montpellier, Inserrn 1061, Serv Univ Psychiat Adulte,Hop Colombiere, Montpellier, France.
   [Chereau, I.; Llorca, P. M.] Univ Auvergne, Fac Med, EA 7280, CMP B,CHU, BP 69, F-63003 Clermont Ferrand, France.
   [D'Amato, T.] Univ Claude Bernard Lyon 1, Ctr Hosp Le Vinatier, Ctr Rech Neurosci Lyon, INSERM U1028,CNRS UMR5292,Pole Est, 95 Bd Pinel,BP 30039, F-69678 Bron, France.
   [Dubertret, C.; Mallet, J.] Univ Paris Diderot, Sorbonne Paris Cite, Fac Med, AP HP,Dept Psychiat,Louis Mourier Hosp,Colombes,I, Paris, France.
   [Dubreucq, J.; Leignier, S.] CH Alpes Isere, Ctr Referent Rehabil Psychosociale, Grenoble, France.
   [Passerieux, C.; Urbach, M.] Univ Versailles St Quentin en Yvelines, UFR Sci Sante Simone Veil, EA 4047 HANDIReSP, Ctr Hosp Versailles,Serv Psychiat & Addictol Adul, Versailles, France.
   [Aouizerate, B.] Univ Bordeaux, NutriNeuro, INRA, U1286, F-33076 Bordeaux, France.
   [Misdrahi, D.] INCIA, CNRS UMR 5287, Bordeaux, France.
   [Godin, O.] UPMC Univ Paris 06, Sorbonne Univ, Inst Pierre Louis Epiderniol & Sante Publ, INSERM,UMR S 1136, F-75013 Paris, France.
C3 Institut National de la Sante et de la Recherche Medicale (Inserm);
   Assistance Publique Hopitaux Paris (APHP); Universite
   Paris-Est-Creteil-Val-de-Marne (UPEC); Hopital Universitaire
   Henri-Mondor - APHP; Aix-Marseille Universite; Assistance
   Publique-Hopitaux de Marseille; Universite de Bordeaux; Universites de
   Strasbourg Etablissements Associes; Universite de Strasbourg; CHU
   Strasbourg; Institut National de la Sante et de la Recherche Medicale
   (Inserm); Universite de Montpellier; CHU de Montpellier; Universite
   Clermont Auvergne (UCA); CHU Clermont Ferrand; Centre National de la
   Recherche Scientifique (CNRS); Institut National de la Sante et de la
   Recherche Medicale (Inserm); Universite Claude Bernard Lyon 1;
   Universite Jean Monnet; CNRS - National Institute for Biology (INSB);
   Assistance Publique Hopitaux Paris (APHP); Universite Paris Cite;
   Hopital Universitaire Louis-Mourier - APHP; Centre Hospitalier de
   Versailles; Universite Paris Saclay; Universite de Bordeaux; INRAE;
   Institut National de la Sante et de la Recherche Medicale (Inserm);
   Universite de Bordeaux; Centre National de la Recherche Scientifique
   (CNRS); CNRS - National Institute for Biology (INSB); Institut National
   de la Sante et de la Recherche Medicale (Inserm); Sorbonne Universite
RP Fond, G (corresponding author), Aix Marseille Univ, Fac Med, Sect Timone, EA 3279,CEReSS Ctr Etud & Rech Serv Sante & Qual, 27 Blvd Jean Moulin, F-13005 Marseille, France.
EM guillaume.fond@ap-hm.fr
RI Schandrin, Aurélie/ISV-4608-2023; Berna, Fabrice/J-2701-2019;
   Capdevielle, Delphine/HTO-4229-2023; TESSIER, Arnaud/A-4022-2017;
   COULON, Nathalie/HLW-3075-2023; Leboyer, Marion/AAW-3648-2021; Boyer,
   Laurent/E-5728-2016; FOND, Guillaume/D-7646-2011
OI dubreucq, julien/0000-0003-4079-4194; Aouizerate,
   Bruno/0000-0002-7092-7747; Capdevielle, Delphine/0000-0002-7146-8554;
   COULON, Nathalie/0000-0001-7765-1117; Misdrahi,
   David/0000-0003-1146-3206; LEBOYER, Marion/0000-0001-5473-3697; D'Amato,
   Thierry/0000-0001-8983-0315; FOND, Guillaume/0000-0003-3249-2030
FU AP-HM (Assistance Publique des Hopitaux de Marseille); Fondation
   FondaMental (RTRS Sante Mentale); Investissements d'Avenir program
   [ANR-11-IDEX-0004-02, ANR-10-COH0-10-01]
FX This work was funded by AP-HM (Assistance Publique des Hopitaux de
   Marseille), Fondation FondaMental (RTRS Sante Mentale), by the
   Investissements d'Avenir program managed by the ANR under reference
   ANR-11-IDEX-0004-02 and ANR-10-COH0-10-01.
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NR 51
TC 22
Z9 22
U1 1
U2 10
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0165-1781
J9 PSYCHIAT RES
JI Psychiatry Res.
PD DEC
PY 2018
VL 270
BP 104
EP 110
DI 10.1016/j.psychres.2018.09.024
PG 7
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA HG4VH
UT WOS:000454972600013
PM 30245372
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Heppner, PS
   Lohr, JB
   Kash, TP
   Jin, H
   Wang, HJ
   Baker, DG
AF Heppner, Pia S.
   Lohr, James B.
   Kash, Taylor P.
   Jin, Hua
   Wang, Hongjun
   Baker, Dewleen G.
TI Metabolic Syndrome: Relative Risk Associated with Post-Traumatic Stress
   Disorder (PTSD) Severity and Antipsychotic Medication Use
SO PSYCHOSOMATICS
LA English
DT Article
ID CORONARY-HEART-DISEASE; DIABETES-MELLITUS; ALLOSTASIS; PREVALENCE;
   DIAGNOSIS; MORTALITY; SYMPTOMS; VETERANS
AB Background: In recent years, numerous lines of converging evidence have revealed an association between post-traumatic stress disorder (PTSD) and impaired physical health outcomes, including cardiovascular disease and metabolic syndrome. Although these findings have been interpreted as indicating a direct association of PTSD with metabolic syndrome and obesity, previous studies have not addressed the important confound of antipsychotic drug usage in this population. Second generation antipsychotic medications themselves are associated with metabolic syndrome and obesity, and it is unclear whether the common utilization of these drugs in PTSD may account for some if not all of the observed metabolic problems. Objective: The present study examined the relative contributions of PTSD severity and use of antipsychotic medications to risk of metabolic syndrome among veterans. Method: Cross-sectional clinical data, including five factors representing metabolic syndrome, psychiatric diagnoses, and medications were gathered from 253 veterans enrolling in mental health services. We used a logistic regression model to measure the relative association of antipsychotic medication use and PTSD severity on risk of metabolic syndrome. Results: We found that antipsychotic medication usage was not uniquely associated with elevated risk of metabolic syndrome (Wald = 0.30, ns) when PTSD severity and other sociodemographic, psychiatric, and behavioral variables were accounted for. Furthermore, PTSD severity continued to be a significant and unique predictor of risk for metabolic syndrome (Wald = 4.04, p < 0.05). Conclusions: These findings suggest that chronic and moderately severe PTSD, independent of antipsychotic medications, is associated with increased risk of metabolic syndrome. (Psychosomatics 2012; 53:550-558)
C1 [Baker, Dewleen G.] VA San Diego Healthcare Syst, VA Ctr Excellence Stress & Mental Hlth 116A, San Diego, CA 92161 USA.
   [Heppner, Pia S.; Lohr, James B.; Baker, Dewleen G.] Univ Calif San Diego, Dept Psychiat, San Diego, CA 92103 USA.
   [Lohr, James B.; Jin, Hua; Wang, Hongjun; Baker, Dewleen G.] VA Ctr Excellence Stress & Mental Hlth, San Diego, CA USA.
C3 US Department of Veterans Affairs; Veterans Health Administration (VHA);
   VA San Diego Healthcare System; University of California System;
   University of California San Diego
RP Baker, DG (corresponding author), VA San Diego Healthcare Syst, VA Ctr Excellence Stress & Mental Hlth 116A, 3350 La Jolla Village Dr, San Diego, CA 92161 USA.
EM dgbaker@ucsd.edu
RI jin, hua/AAX-1569-2020; Wang, Hongjun/AAJ-3852-2020; Baker,
   Dewleen/O-4957-2019
FU VA Research mechanisms (VA Cooperative Study Program); VA Center of
   Excellence for Stress and Mental Health (CESAMH)
FX This study, data collection, and analysis have been funded by through VA
   Research mechanisms (VA Cooperative Study Program) and the VA Center of
   Excellence for Stress and Mental Health (CESAMH). The study acknowledges
   data collection efforts of Cincinnati VA PTSD and Gulf War Program staff
   and researchers.
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NR 34
TC 24
Z9 25
U1 0
U2 15
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0033-3182
EI 1545-7206
J9 PSYCHOSOMATICS
JI Psychosomatics
PD NOV-DEC
PY 2012
VL 53
IS 6
BP 550
EP 558
DI 10.1016/j.psym.2012.05.005
PG 9
WC Psychiatry; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry; Psychology
GA 049KC
UT WOS:000311980900006
PM 23157993
OA Bronze
DA 2025-06-11
ER

PT J
AU Toschi-Dias, E
   Trombetta, IC
   da Silva, VJD
   Maki-Nunes, C
   Alves, MJNN
   Angelo, LF
   Cepeda, FX
   Martinez, DG
   Negrao, CE
   Rondon, MUPB
AF Toschi-Dias, Edgar
   Trombetta, Ivani C.
   Dias da Silva, Valdo Jose
   Maki-Nunes, Cristiane
   Alves, Maria Janieire N. N.
   Angelo, Luciana F.
   Cepeda, Felipe X.
   Martinez, Daniel G.
   Negrao, Carlos Eduardo
   Rondon, Maria Urbana P. B.
TI Symptoms of anxiety and mood disturbance alter cardiac and peripheral
   autonomic control in patients with metabolic syndrome
SO EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
LA English
DT Article
DE Anxiety; Mood disturbance; Sympathetic activity; Baroreflex sensitivity;
   Metabolic syndrome
ID HEART-RATE-VARIABILITY; BAROREFLEX SENSITIVITY; BLOOD-PRESSURE; STRESS;
   EXERCISE; ACTIVATION; DEPRESSION; HYPOTHALAMUS; HYPERTENSION; VOLUME
AB Previous investigations show that metabolic syndrome (MetSyn) causes sympathetic hyperactivation. Symptoms of anxiety and mood disturbance (AMd) provoke sympatho-vagal imbalance. We hypothesized that AMd would alter even further the autonomic function in patients with MetSyn. Twenty-six never-treated patients with MetSyn (ATP-III) were allocated to two groups, according to the levels of anxiety and mood disturbance: (1) with AMd (MetSyn + AMd, n = 15), and (2) without AMd (MetSyn, n = 11). Ten healthy control subjects were also studied (C, n = 10). AMd was determined using quantitative questionnaires. Muscle sympathetic nerve activity (MSNA, microneurography), blood pressure (oscillometric beat-to-beat basis), and heart rate (ECG) were measured during a baseline 10-min period. Spectral analysis of RR interval and systolic arterial pressure were analyzed, and the power of low (LF) and high (HF) frequency bands were determined. Sympatho-vagal balance was obtained by LF/HF ratio. Spontaneous baroreflex sensitivity (BRS) was evaluated by calculation of alpha-index. MSNA was greater in patients with MetSyn + AMd compared with MetSyn and C. Patients with MetSyn + AMd showed higher LF and lower HF power compared with MetSyn and C. In addition, LF/HF balance was higher in MetSyn + AMd than in MetSyn and C groups. BRS was decreased in MetSyn + AMd compared with MetSyn and C groups. Anxiety and mood disturbance alter autonomic function in patients with MetSyn. This autonomic dysfunction may contribute to the increased cardiovascular risk observed in patients with mood alterations.
C1 [Toschi-Dias, Edgar; Trombetta, Ivani C.; Maki-Nunes, Cristiane; Alves, Maria Janieire N. N.; Angelo, Luciana F.; Cepeda, Felipe X.; Martinez, Daniel G.; Negrao, Carlos Eduardo; Rondon, Maria Urbana P. B.] Univ Sao Paulo, Sch Med, Heart Inst InCor, BR-05508030 Sao Paulo, Brazil.
   [Dias da Silva, Valdo Jose] Univ Fed Triangulo Mineiro, Sch Med, Uberaba, MG, Brazil.
   [Negrao, Carlos Eduardo; Rondon, Maria Urbana P. B.] Univ Sao Paulo, Sch Phys Educ & Sport, BR-05508030 Sao Paulo, Brazil.
C3 Universidade de Sao Paulo; Universidade Federal do Triangulo Mineiro;
   Universidade de Sao Paulo
RP Rondon, MUPB (corresponding author), Univ Sao Paulo, Sch Phys Educ & Sport, Av Prof Mello de Moraes,65 Butanta, BR-05508030 Sao Paulo, Brazil.
EM urbana@usp.br
RI Negrao, Carlos/C-4281-2012; Toschi-Dias, Edgar/C-9685-2013; Toschi-Dias,
   Edgar/AAP-9528-2020; Trombetta, Ivani/G-5839-2012; Alves, Maria
   Janieire/G-4548-2010; Pinto Brandao Rondon, Maria Urbana/G-5272-2012;
   Godoy Martinez, Daniel/D-9135-2015; Xerez Cepeda, Felipe/G-3340-2013
OI Pinto Brandao Rondon, Maria Urbana/0000-0002-4134-6126; Godoy Martinez,
   Daniel/0000-0003-0034-7963; Toschi-Dias, Edgar/0000-0002-5226-2956;
   Negrao, Carlos Eduardo/0000-0003-4652-1226; Xerez Cepeda,
   Felipe/0000-0003-1544-3499
FU Conselho Nacional de Pesquisa (CNPq) [476385/2006-7, 140643/2009-5,
   301867/2010-0, 308068/2011-4]; Fundacao de Amparo a Pesquisa do Estado
   de Sao Paulo (FAPESP) [2010/50048-1]; Fundacao Zerbini; Fundacao de
   Amparo a Pesquisa (FAPESP) [2008/03714-6]; Coordenacao de
   Aperfeicoamento de Pessoal de Nivel Superior (CAPES); Fundacao de Amparo
   a Pesquisa do Estado de Sao Paulo (FAPESP) [10/50048-1, 08/03714-6]
   Funding Source: FAPESP; Swedish Research Council [2008-03714] Funding
   Source: Swedish Research Council
FX This study was supported by Conselho Nacional de Pesquisa (CNPq #
   476385/2006-7), by Fundacao de Amparo a Pesquisa do Estado de Sao Paulo
   (FAPESP # 2010/50048-1) and, in part, by Fundacao Zerbini. Toschi-Dias
   E, Negrao CE and Rondon MUPB were supported by Conselho Nacional de
   Pesquisa (CNPq # 140643/2009-5, # 301867/2010-0, # 308068/2011-4,
   respectively). Trombetta IC was supported by Fundacao de Amparo a
   Pesquisa (FAPESP # 2008/03714-6). Maki-Nunes C and Martinez DG were
   supported by Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior
   (CAPES).
CR Andrade L, 2001, BRAZ J MED BIOL RES, V34, P367, DOI 10.1590/S0100-879X2001000300011
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NR 31
TC 9
Z9 10
U1 0
U2 26
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1439-6319
J9 EUR J APPL PHYSIOL
JI Eur. J. Appl. Physiol.
PD MAR
PY 2013
VL 113
IS 3
BP 671
EP 679
DI 10.1007/s00421-012-2476-8
PG 9
WC Physiology; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology; Sport Sciences
GA 087PF
UT WOS:000314773500013
PM 22918560
DA 2025-06-11
ER

PT J
AU Viinamäki, H
   Heiskanen, T
   Lehto, SM
   Niskanen, L
   Koivumaa-Honkanen, H
   Tolmunen, T
   Honkalampi, K
   Saharinen, T
   Haatainen, K
   Hintikka, J
AF Viinamaki, H.
   Heiskanen, T.
   Lehto, S. M.
   Niskanen, L.
   Koivumaa-Honkanen, H.
   Tolmunen, T.
   Honkalampi, K.
   Saharinen, T.
   Haatainen, K.
   Hintikka, J.
TI Association of depressive symptoms and metabolic syndrome in men
SO ACTA PSYCHIATRICA SCANDINAVICA
LA English
DT Article
DE depression; metabolic syndrome; population-based
ID C-REACTIVE PROTEIN; INTERNATIONAL-DIABETES-FEDERATION; 3RD
   NATIONAL-HEALTH; YOUNG-ADULTS; RISK-FACTORS; US ADULTS; MORTALITY;
   PREVALENCE; ANXIETY; POPULATION
AB Objective: To explore the relationship between several indicators of depression and metabolic syndrome (MetS).
   Method: A population-based sample with high (HMS group) or low (LMS group) levels of mental symptoms, including those of depression, in three follow-ups participated in a clinical examination in 2005 (n = 223). MetS was determined according to the NCEP criteria.
   Results: The prevalence of MetS was 49% in men and 21% in women. Men with MetS had higher rates of major depressive disorder than other men. They also displayed higher Hamilton Rating Scale for Depression (HDRS) scores and more often signs of suicidality. In logistic regression analyses, higher HDRS scores (OR 1.31, 95% CI 1.04-1.64) and belonging to the HMS group (OR 10.1, 95% CI 1.98-51.3) were independent associates for MetS but only in men.
   Conclusion: The results highlight that there is an association between long-term depressive symptoms and the emergence of MetS, especially in men.
C1 [Viinamaki, H.; Heiskanen, T.; Lehto, S. M.; Niskanen, L.; Koivumaa-Honkanen, H.; Tolmunen, T.; Honkalampi, K.; Saharinen, T.; Haatainen, K.; Hintikka, J.] Kuopio Univ Hosp, Dept Psychiat, FIN-70211 Kuopio, Finland.
   [Viinamaki, H.; Heiskanen, T.; Lehto, S. M.; Niskanen, L.; Koivumaa-Honkanen, H.; Tolmunen, T.; Honkalampi, K.; Saharinen, T.; Haatainen, K.; Hintikka, J.] Kuopio Univ Hosp, Dept Med, FIN-70211 Kuopio, Finland.
   [Viinamaki, H.; Heiskanen, T.; Lehto, S. M.; Niskanen, L.; Koivumaa-Honkanen, H.; Tolmunen, T.; Honkalampi, K.; Saharinen, T.; Haatainen, K.; Hintikka, J.] Univ Kuopio, Inst Clin Med, FIN-70211 Kuopio, Finland.
   [Koivumaa-Honkanen, H.] Univ Oulu, Inst Clin Med, Oulu, Finland.
   [Koivumaa-Honkanen, H.] Muurola Hosp, Lapland Hosp Dist, Rovaniemi, Finland.
C3 Kuopio University Hospital; Kuopio University Hospital; University of
   Eastern Finland; University of Oulu
RP Viinamäki, H (corresponding author), Kuopio Univ Hosp, Dept Psychiat, POB 1777, FIN-70211 Kuopio, Finland.
EM heimo.viinamaki@kuh.fi
RI Koivumaa-Honkanen, Heli/L-1274-2015
OI Lehto, Soili/0000-0003-4324-6679
FU Kuopio University Hospital; Academy of Finland [116996]; Academy of
   Finland (AKA) [116996] Funding Source: Academy of Finland (AKA)
FX The clinical study of subjects was supported with an EVO grant from
   Kuopio University Hospital. HK-H is supported by a grant from the
   Academy of Finland ( 116996).
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NR 41
TC 60
Z9 64
U1 0
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0001-690X
EI 1600-0447
J9 ACTA PSYCHIAT SCAND
JI Acta Psychiatr. Scand.
PD JUL
PY 2009
VL 120
IS 1
BP 23
EP 29
DI 10.1111/j.1600-0447.2008.01333.x
PG 7
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 453TP
UT WOS:000266636100004
PM 19133875
DA 2025-06-11
ER

PT J
AU Hadi, A
   Sepandi, M
   Marx, W
   Moradi, S
   Parastouei, K
AF Hadi, Amir
   Sepandi, Mojtaba
   Marx, Wolfgang
   Moradi, Sajjad
   Parastouei, Karim
TI Clinical and psychological responses to synbiotic supplementation in
   obese or overweight adults: A randomized clinical trial
SO COMPLEMENTARY THERAPIES IN MEDICINE
LA English
DT Article
DE Synbiotics; Microbiome; Obesity; Metabolic profile; Depression; Anxiety;
   Stress
ID METABOLIC SYNDROME; PROBIOTICS; DISEASE; CHOLESTEROL; MICROBIOME;
   PREBIOTICS; DEPRESSION; MANAGEMENT; BURDEN; UPDATE
AB Background: Obesity is highly prevalent worldwide. Emerging clinical studies suggest that pre- and pro- biotic formulations may be effective interventions for the management of obesity and associated metabolic complications. The current trial was conducted to assess the effect of synbiotic supplementation on anthropometric indices, glycemic and lipid profile, blood pressure, and psychological status of adults with overweight or obesity.
   Methods: This randomized double-blind, placebo-controlled trial was conducted on 60 adults with overweight or obesity. Participants were randomly assigned into two groups to receive either synbiotics (n = 30) in form of a 500 mg capsule (containing Lactobacillus acidophilus, Lactobacillus casei and Bifidobacterium bifidum plus inulin) or placebo (n = 30) for 8 weeks. The level of total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), fasting blood glucose (FPG), insulin, body weight, body mass index (BMI), waist circumference (WC), systolic blood pressure (SBP), diastolic blood pressure (DBP), stress, anxiety, and depression were measured at the baseline and end of the study.
   Results: In total, 59 subjects (39 men and 20 women) completed the present study. A significant between-group decrease in body weight (P = 0.03), TC (P = 0.01), TG (P = 0.02), LDL-C (P = 0.01), stress (P < 0.001), anxiety (P = 0.03), and depression (P = 0.03) was found in the synbiotic group compared to the placebo. However, synbiotics had no significant effect on HDL-C, SBP, DBP, FPG and fasting insulin concentrations, as well the BMI and WC (P < 0.05).
   Conclusion: The present study showed that synbiotic supplementation can confer a number of health benefits including improvements in TG, TC, LDL-C, body weight, stress, anxiety, and depression to subjects that are overweight or obesity.
C1 [Hadi, Amir; Sepandi, Mojtaba; Parastouei, Karim] Baqiyatallah Univ Med Sci, Hlth Res Ctr, Life Style Inst, Tehran, Iran.
   [Hadi, Amir; Parastouei, Karim] Baqiyatallah Univ Med Sci, Fac Hlth, Dept Nutr & Food Hyg, Tehran, Iran.
   [Sepandi, Mojtaba] Baqiyatallah Univ Med Sci, Fac Hlth, Dept Epidemiol & Biostat, Tehran, Iran.
   [Marx, Wolfgang] Deakin Univ, Sch Med, iMPACT, Geelong, Vic, Australia.
   [Moradi, Sajjad] FDA, Halal Res Ctr, IRI, Tehran, Iran.
C3 Baqiyatallah University of Medical Sciences (BMSU); Baqiyatallah
   University of Medical Sciences (BMSU); Baqiyatallah University of
   Medical Sciences (BMSU); Deakin University
RP Parastouei, K (corresponding author), Baqiyatallah Univ Med Sci, Hlth Res Ctr, Life Style Inst, Tehran, Iran.
EM Parastouei@gmail.com
RI Marx, Wolfgang/AFO-7355-2022; Sepandi, Mojtaba/I-8561-2014; Hadi,
   Amir/AAK-4634-2020
OI Marx, Wolfgang/0000-0002-8556-8230
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NR 58
TC 47
Z9 47
U1 0
U2 37
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0965-2299
EI 1873-6963
J9 COMPLEMENT THER MED
JI Complement. Ther. Med.
PD DEC
PY 2019
VL 47
AR 102216
DI 10.1016/j.ctim.2019.102216
PG 6
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Integrative & Complementary Medicine
GA JU4JI
UT WOS:000501643500038
PM 31780038
DA 2025-06-11
ER

PT J
AU Al-Khatib, Y
   Akhtar, MA
   Kanawati, MA
   Mucheke, R
   Mahfouz, M
   Al-Nufoury, M
AF Al-Khatib, Yousef
   Akhtar, Muhammad Adeel
   Kanawati, M. Ali
   Mucheke, Rumbidzai
   Mahfouz, Maria
   Al-Nufoury, Maysan
TI Depression and Metabolic Syndrome: A Narrative Review
SO CUREUS JOURNAL OF MEDICAL SCIENCE
LA English
DT Review
DE depression and diabetes; cardiovascular complications; metabolic
   syndrome; depression; obesity
ID MAJOR DEPRESSION; PSYCHOLOGICAL DISTRESS; CARDIOVASCULAR-DISEASE;
   BIPOLAR DISORDER; MENTAL-DISORDERS; RISK-FACTORS; JOLLY FAT; US ADULTS;
   OBESITY; ASSOCIATION
AB We reviewed the literature to investigate the relationship between depression and metabolic syndrome. Major depressive disorder is characterized by a low mood or a loss of interest for longer than two weeks. Metabolic syndrome describes multiple metabolic risk factors including obesity, insulin resistance, dyslipidemia, and hypertension. We divided our findings into environmental, genetic, epigenetic, and biological pathway links between depression and the different aspects of metabolic syndrome. We found various sources linking obesity and metabolic syndrome genetically, environmentally, biological pathway-wise, and, while not fully explored, epigenetically. Diabetes and depression were also found to be linked environmentally with both conditions increasing the risk of the other. Depression was also shown to be linked to cardiovascular complications as it increased the risk of occurrence of such complications in healthy people. These findings have led us to believe that there is a link between depression and metabolic syndrome on various levels, especially obesity.
C1 [Al-Khatib, Yousef] Royal Coll Surgeons Ireland, Orthopaed, Dublin, Ireland.
   [Akhtar, Muhammad Adeel] Royal Coll Surgeons Ireland, Trauma & Orthopaed, Dublin, Ireland.
   [Kanawati, M. Ali] Royal Coll Surgeons Ireland, Internal Med, Dublin, Ireland.
   [Mucheke, Rumbidzai] Univ Huddersfield, Operating Dept Practice, Huddersfield, W Yorkshire, England.
   [Mahfouz, Maria] Royal Coll Surgeons Ireland, Med, Dublin, Ireland.
   [Al-Nufoury, Maysan] Spinney Hosp, Psychiat, Manchester, Lancs, England.
C3 Royal College of Surgeons - Ireland; Royal College of Surgeons -
   Ireland; Royal College of Surgeons - Ireland; University of
   Huddersfield; Royal College of Surgeons - Ireland
RP Al-Khatib, Y (corresponding author), Royal Coll Surgeons Ireland, Orthopaed, Dublin, Ireland.
EM yousefal-khatib@outlook.com
RI Akhtar, Muhammad Shaheer/GPX-0675-2022
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NR 96
TC 31
Z9 32
U1 6
U2 35
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
EI 2168-8184
J9 CUREUS J MED SCIENCE
JI Cureus J Med Sci
PD FEB 12
PY 2022
VL 14
IS 2
AR e22153
DI 10.7759/cureus.22153
PG 10
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA ZD4DV
UT WOS:000758151000009
PM 35308733
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Sachinidis, A
   Doumas, M
   Imprialos, K
   Stavropoulos, K
   Katsimardou, A
   Athyros, VG
AF Sachinidis, Alexandros
   Doumas, Michael
   Imprialos, Konstantinos
   Stavropoulos, Konstantinos
   Katsimardou, Alexandra
   Athyros, Vasilios G.
TI Dysmetabolic Iron Overload in Metabolic Syndrome
SO CURRENT PHARMACEUTICAL DESIGN
LA English
DT Review
DE Serum ferritin; dysmetabolic iron overload syndrome; metabolic syndrome;
   insuline resistance; type two diabetes; arterial hypertension
ID FATTY LIVER-DISEASE; INSULIN-RESISTANCE SYNDROME;
   CORONARY-HEART-DISEASE; SERUM FERRITIN; HEPATIC IRON; OXIDATIVE STRESS;
   HYPOGONADOTROPIC HYPOGONADISM; NONALCOHOLIC STEATOHEPATITIS;
   PHENOTYPIC-EXPRESSION; THYROID-FUNCTION
AB Background: We sought to determine the association of dysmetabolic iron overload syndrome (DIOS) with metabolic syndrome (MetS).
   Methods: Several studies have shown that DIOS is associated with Mets, mainly through the pathogenesis of its components: type 2 diabetes mellitus (T2DM), essential hypertension, non-alcoholic fatty liver disease (NAFLD) and polycystic ovary syndrome (POS).
   Results: Serum ferritin levels increase proportionally according to the degree of insulin resistance (IR) and the number of components of Mets. Moreover, DIOS predicts the onset of T2DM and NAFLD. Dysregulation of iron metabolism in DIOS is due to a multifactorial and dynamic process triggered by an unhealthy diet, facilitated by environmental and genetic cofactors, and resulting in a bidirectional relation between the liver and visceral adipose tissue (VAT). Iron removal combined with a healthy diet improved both insulin sensitivity and beta-cell function, but had no significant effect on blood glucose; however, phlebotomy therapy might be considered with conflicting results.
   Conclusion: Iron overload is closely associated with metabolic syndrome and its components; however, it remains under-appreciated in everyday clinical practice. Diet and lifestyle modification offer some clinical benefit; however, it is not adequate for successful management of the disease. The results of phlebotomy remain controversial, underlying the necessity of further efforts in this field.
C1 [Sachinidis, Alexandros; Doumas, Michael; Imprialos, Konstantinos; Stavropoulos, Konstantinos; Katsimardou, Alexandra; Athyros, Vasilios G.] Aristotle Univ Thessaloniki, Hippocrat Hosp, Dept Internal Med, Med Sch,Propaedeut 2, Thessaloniki, Greece.
   [Doumas, Michael; Imprialos, Konstantinos] Georgetown Univ, Washington, DC 20057 USA.
   [Doumas, Michael; Imprialos, Konstantinos] VAMC, Washington, DC USA.
   [Doumas, Michael; Imprialos, Konstantinos] George Washington Univ, Washington, DC USA.
C3 Aristotle University of Thessaloniki; Georgetown University; George
   Washington University
RP Athyros, VG (corresponding author), Aristotle Univ Thessaloniki, Dept Internal Med, Hippocrat Hosp, Med Sch, Thessaloniki, Greece.
EM vathyros@gmail.com
RI Athyros, V.G./H-5328-2019; Stavropoulos, Konstantinos/H-8910-2019
OI Imprialos, Konstantinos/0000-0003-0379-0522; Athyros,
   Vasilios/0000-0002-0882-8676; Doumas, Michael/0000-0002-7269-8044;
   SACHINIDIS, ALEXANDROS/0000-0002-5233-9204
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NR 96
TC 46
Z9 50
U1 0
U2 18
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1381-6128
EI 1873-4286
J9 CURR PHARM DESIGN
JI Curr. Pharm. Design
PY 2020
VL 26
IS 10
BP 1019
EP 1024
DI 10.2174/1381612826666200130090703
PG 6
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA LK7ZQ
UT WOS:000531080500005
PM 32000639
DA 2025-06-11
ER

PT J
AU Zambon, A
   Pauletto, P
   Crepaldi, G
AF Zambon, A
   Pauletto, P
   Crepaldi, G
TI Review article: the metabolic syndrome - a chronic cardiovascular
   inflammatory condition
SO ALIMENTARY PHARMACOLOGY & THERAPEUTICS
LA English
DT Review
ID C-REACTIVE PROTEIN; INSULIN-RESISTANCE SYNDROME; ENDOTHELIAL
   DYSFUNCTION; DISEASE; LDL; ATHEROSCLEROSIS; LIPOPROTEINS; CELLS; RISK;
   MEN
AB The atherosclerotic process is regulated by inflammatory mechanisms, which also appear to be involved in the modulation of insulin-resistance, a key player in the pathogenesis of the metabolic syndrome (MS). The interaction between components of the clinical phenotype of the MS with its biological phenotype (insulin resistance, dyslipidaemia, etc.) contributes to the development of a pro-inflammatory state characterized by an increased oxidative stress (i.e. oxidized lipoproteins) and a chronic, subclinical vascular inflammation, as also suggested by the increased C reactive protein (CRP) concentration found in patients with MS. The subclinical inflammatory state peculiar of the MS modulates the atherosclerotic process at different stages, resulting in: (i) endothelial dysfunction and increased expression of endothelial adhesion molecules; (ii) an enhanced recruitment of monocytes within the arterial wall, in the early stages of the atherosclerotic process; leading to (iii) the formation of an unstable atherosclerotic plaque, rich in inflammatory cells, which is the culprit lesion in the vast majority of both coronary and cerebrovascular events observed in with MS.
C1 Univ Padua, Dept Med & Surg Sci, Padua, Italy.
   Univ Padua, Dept Clin & Expt Med, Padua, Italy.
C3 University of Padua; University of Padua
RP Univ Padua Polyclin, Dept Med & Surg Sci, Med Clin 1, Via Giustiniani 2, I-35128 Padua, Italy.
EM alberto.zambon@unipd.it
RI Zambon, Alberto/J-2122-2012
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NR 19
TC 48
Z9 53
U1 1
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0269-2813
EI 1365-2036
J9 ALIMENT PHARM THER
JI Aliment. Pharmacol. Ther.
PD NOV
PY 2005
VL 22
SU 2
BP 20
EP 23
DI 10.1111/j.1365-2036.2005.02589.x
PG 4
WC Gastroenterology & Hepatology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Pharmacology & Pharmacy
GA 982GU
UT WOS:000233146900005
PM 16225466
OA Bronze
DA 2025-06-11
ER

PT J
AU Kim, J
   Kang, S
   Hong, H
   Joo, M
   Kang, H
AF Kim, Jeonghyeon
   Kang, Seamon
   Hong, Haeryun
   Joo, Mingyu
   Kang, Hyunsik
TI A Non-Randomized Combined Program of Walking and Low-Load Resistance
   Exercise Improves Cognitive Function and Cardiometabolic Risk Factors in
   Community-Dwelling Elderly Women
SO HEALTHCARE
LA English
DT Article
DE exercise intervention; cognitive decline; cardiometabolic risk factors;
   functional fitness
ID METABOLIC SYNDROME; OLDER-ADULTS; KOREAN VERSION; STRENGTH; IMPAIRMENT;
   DEMENTIA; TRIALS
AB Background: This study examines whether changes in cardiometabolic risk factors, functional fitness, and depressive symptoms following a six-month exercise intervention were associated with cognitive function in Korean women aged 65 years and older. Methods: A non-randomized study design was used to compare post-intervention changes in measured variables between control (n = 30) and exercise (n = 30) groups. The exercise intervention consisted of three days of low-load resistance exercise and two days of walking. Cognitive function and depressive symptoms were assessed with the Korean version of the Mini-Mental State Examination and the Korean version of the Geriatric Depression Scale, respectively. Functional fitness was measured using a senior fitness test battery. Results: The exercise group showed a significant improvement in cognitive function (p < 0.001) in conjunction with significant decreases in blood glucose (p = 0.052), triglycerides (p = 0.011), insulin (p = 0.002), tumor necrosis factor-alpha (p = 0.043), and depressive symptoms (p = 0.006) and an increase in interleukin-10 (p = 0.037), compared with the control group. Multivariate stepwise regression showed that changes in depressive symptoms (p < 0.001), insulin resistance (p < 0.001), and upper body muscle strength (p = 0.003) were positively associated with cognitive function. Conclusion: A six-month exercise intervention consisting of walking and low-load/high-repetition elastic band resistance exercise has the potential to improve cognitive function, as well as physical function and cardiometabolic risk factors, and to decrease depressive symptoms in older women.
C1 [Kim, Jeonghyeon; Kang, Seamon; Hong, Haeryun; Joo, Mingyu; Kang, Hyunsik] Sungkyunkwan Univ, Coll Sport Sci, Suwon 16419, South Korea.
C3 Sungkyunkwan University (SKKU)
RP Kang, H (corresponding author), Sungkyunkwan Univ, Coll Sport Sci, Suwon 16419, South Korea.
EM hkang@skku.edu
OI KANG, HYUNSIK/0000-0002-8611-1873
FU National Research Foundation - Korean government [NRF-2020R1A2C1009365]
FX This study was supported by a National Research Foundation grant funded
   by the Korean government (NRF-2020R1A2C1009365).
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NR 42
TC 2
Z9 2
U1 1
U2 8
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2227-9032
J9 HEALTHCARE-BASEL
JI Healthcare
PD OCT
PY 2022
VL 10
IS 10
AR 2106
DI 10.3390/healthcare10102106
PG 12
WC Health Care Sciences & Services; Health Policy & Services
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services
GA 5R1GY
UT WOS:000874267700001
PM 36292553
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Penninx, BWJH
AF Penninx, Brenda W. J. H.
TI Depression and cardiovascular disease: Epidemiological evidence on their
   linking mechanisms
SO NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
LA English
DT Review
DE Depression; Cardiovascular; Lifestyle; Metabolic syndrome; Inflammation;
   Cortisol; Cardiac autonomic control; Epidemiology
ID HEART-RATE-VARIABILITY; C-REACTIVE PROTEIN; CORTISOL AWAKENING RESPONSE;
   METABOLIC SYNDROME; MAJOR DEPRESSION; ANTIDEPRESSANT MEDICATION;
   MENTAL-DISORDERS; ANXIETY NESDA; META-ANALYSIS; MYOCARDIAL-INFARCTION
AB Depression's burden of disease goes beyond functioning and quality of life and extends to somatic health. Results from longitudinal cohort studies converge in illustrating that major depressive disorder (MDD) subsequently increases the risk of cardiovascular morbidity and mortality with about 80%. The impact of MDD on cardiovascular health may be partly explained by mediating mechanisms such as unhealthy lifestyle (smoking, excessive alcohol use, physical inactivity, unhealthy diet, therapy non-compliance) and unfavorable pathophysiological disturbances (autonomic, HPA-axis, metabolic and immuno-inflammatory dysregulations). A summary of the literature findings as well as relevant results from the large-scale Netherlands Study of Depression and Anxiety (N =2981) are presented. Persons with MDD have significantly worse lifestyles as well as more pathophysiological disturbances as compared to healthy controls. Some of these differences seem to be specific for (typical versus 'atypical', or antidepressant treated versus drug-naive) subgroups of MDD patients. Alternative explanations are also present, namely undetected confounding, iatrogenic effects or 'third factors' such as genetics. (C) 2016 Elsevier Ltd. All rights reserved.
C1 [Penninx, Brenda W. J. H.] Vrije Univ Amsterdam, Med Ctr, Dept Psychiat, EMGO Inst Hlth & Care Res, Amsterdam, Netherlands.
   [Penninx, Brenda W. J. H.] Vrije Univ Amsterdam, Med Ctr, Neurosci Campus Amsterdam, Amsterdam, Netherlands.
C3 Vrije Universiteit Amsterdam; Vrije Universiteit Amsterdam
RP Penninx, BWJH (corresponding author), Vrije Univ Amsterdam, Med Ctr, Dept Psychiat, AJ Ernststr 1187, NL-1081 HL Amsterdam, Netherlands.
EM b.penninx@vumc.nl
RI Penninx, Brenda/S-7627-2017
FU VICI grant (NWO) [91811602]
FX Penninx was supported through a VICI grant (NWO grant 91811602).
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NR 101
TC 346
Z9 374
U1 11
U2 141
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0149-7634
EI 1873-7528
J9 NEUROSCI BIOBEHAV R
JI Neurosci. Biobehav. Rev.
PD MAR
PY 2017
VL 74
SI SI
BP 277
EP 286
DI 10.1016/j.neubiorev.2016.07.003
PN B
PG 10
WC Behavioral Sciences; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Behavioral Sciences; Neurosciences & Neurology
GA EM9AF
UT WOS:000395602500004
PM 27461915
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Kabthymer, RH
   Techane, SN
   Hailemariam, S
   Bekele, YA
   Mekuriaw, B
AF Kabthymer, Robel Hussen
   Techane, Solomon Nega
   Hailemariam, Solomon
   Bekele, Yibeltal Alemu
   Mekuriaw, Birhanie
TI Metabolic syndrome among people with mental illness in sub Saharan
   Africa: Female gender as a factor. A Systematic review and meta-analysis
SO ANNALS OF MEDICINE AND SURGERY
LA English
DT Review
DE Metabolic syndrome; Syndrome x; Low income setting; Mental disorder
ID PREVALENCE; COMPONENTS; DISORDERS; RISK
AB Background: The prevalence of metabolic syndrome among psychiatric patients in developing nations is mounting alarmingly and it is a reason for decreased life expectancy and quality of life of people with mental illness. Although great discrepant epidemiological studies have been carried out in Sub Saharan African countries, there has no systematic review and meta-analysis conducted. Therefore, summarized evidence has a paramount importance for policy makers and health planning. This study aims to estimate the prevalence of metabolic syndrome and to examine the effect of gender on metabolic syndrome among people with mental illness in sub Saharan Africa.
   Method: Systematic literature search was performed using PubMed, CINAHL, Web of science, Global health electronic databases. In addition, gray literatures were retrieved from Google and Google scholar. Two authors independently extracted all the necessary data using a format prepared in Microsoft Excel. Data analysis was done using STATA Version 14 (software). The heterogeneity of the studies was assessed using I(2)test.Randomeffects model was used to estimate pooled prevalence of MetS and its odds ratio. Publication bias was checked using Funnel plot and Egge's test.
   Result: 1306 studies were reviewed and nine studies fulfilling the inclusion criteria were selected for the metaanalysis. The meta-analysis of nine studies that included 1896 participants found a prevalence rate of metabolic syndrome which was performed based on assessment criteria; JIS criteria prevalence 21.11% (95% CI: 17.93-24.29), IDF criteria 23.77% (95% CI: 15.41-32.12) and NCEP ATP-III criteria 21.63% (95% CI: 16.30-26.96). Female gender (AOR = 3.00; 95% CI: 1.98-4.55) was found to have a significant association with metabolic syndrome.
   Conclusion: The prevalence of metabolic syndrome among people with mental illness in sub Saharan Africa is high in various assessment criteria. The likelihood is significantly increased in females than males. Metabolic syndrome increases by three folds among females with mental illness as compared to their counterparts.
C1 [Kabthymer, Robel Hussen; Hailemariam, Solomon] Dilla Univ, Coll Hlth Sci & Med, Sch Publ Hlth, Dilla, Ethiopia.
   [Techane, Solomon Nega] Dilla Univ, Coll Hlth Sci & Med, Sch Med, Dilla, Ethiopia.
   [Mekuriaw, Birhanie] Dilla Univ, Coll Hlth Sci & Med, Dept Psychiat, Dilla, Ethiopia.
   [Bekele, Yibeltal Alemu] Bahir Dar Univ, Coll Hlth Sci & Med, Dept Reprod Hlth, Bahirdar, Ethiopia.
C3 Dilla University; Dilla University; Dilla University; Bahir Dar
   University
RP Kabthymer, RH (corresponding author), Dilla Univ, Coll Hlth Sci & Med, Sch Publ Hlth, Dilla, Ethiopia.
EM robelk@du.edu.et; sola.nega@gmail.com; solomon0917242124@gmail.com;
   yibeltalalemu6@gmail.com; birhanie2013@gmail.com
RI Kabthymer, Robel/AAX-3597-2020
OI kabthymer, robel/0000-0002-6734-0312; Mekuriaw,
   Birhanie/0000-0002-0600-0234; Bekele, Yibeltal/0000-0003-1272-7824
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NR 35
TC 3
Z9 3
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 2049-0801
J9 ANN MED SURG
JI Ann. Med. Surg.
PD MAY
PY 2021
VL 65
AR 102351
DI 10.1016/j.amsu.2021.102351
EA MAY 2021
PG 7
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA SU3YP
UT WOS:000663077700004
PM 34007445
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Yates, JD
   Aldous, JWF
   Bailey, DP
   Chater, AM
   Mitchell, ACS
   Richards, JC
AF Yates, James D.
   Aldous, Jeffrey W. F.
   Bailey, Daniel P.
   Chater, Angel M.
   Mitchell, Andrew C. S.
   Richards, Joanna C.
TI The Prevalence and Predictors of Hypertension and the Metabolic Syndrome
   in Police Personnel
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Article
DE hypertension; metabolic syndrome; stress; sitting time; police
ID BLOOD-PRESSURE; RISK-FACTORS; CARDIOVASCULAR-DISEASE; SEDENTARY
   BEHAVIORS; WAIST CIRCUMFERENCE; PHYSICAL-ACTIVITY; ASSOCIATION;
   OFFICERS; STRESS; VALUES
AB Hypertension and metabolic syndrome (METSYN) are reportedly high in police forces. This may contribute to health deterioration and absenteeism in police personnel. Police forces comprise of staff in 'operational' and 'non-operational' job types but it is not known if job type is associated to hypertension and METSYN prevalence. This study aimed to explore the prevalence of hypertension and METSYN, the factors associated with the risk of hypertension and METSYN, and compare physiological, psychological, and behavioural factors between operational and non-operational police personnel. Cross-sectional data was collected from 77 operational and 60 non-operational police workers. Hypertension and METSYN were prevalent in 60.5% and 20% of operational and 60.0% and 13.6% of non-operational police personnel, respectively (p > 0.05). Operational job type, moderate organisational stress (compared with low stress) and lower high-density lipoprotein cholesterol were associated with lower odds of hypertension, whereas increasing body mass index was associated with increased odds of hypertension (p < 0.05). None of the independent variables were significantly associated with the odds of METSYN. Operational police had several increased cardiometabolic risk markers compared with non-operational police. Given the high prevalence of hypertension and METSYN in operational and non-operational personnel, occupational health interventions are needed for the police and could be informed by the findings of this study.
C1 [Yates, James D.; Aldous, Jeffrey W. F.; Bailey, Daniel P.; Chater, Angel M.; Mitchell, Andrew C. S.; Richards, Joanna C.] Univ Bedfordshire, Inst Sport & Phys Act Res, Bedford MK41 9EA, England.
   [Bailey, Daniel P.] Brunel Univ London, Sedentary Behav Hlth & Dis Res Grp, Uxbridge UB8 3PH, Middx, England.
   [Bailey, Daniel P.] Brunel Univ London, Dept Life Sci, Div Sport Hlth & Exercise Sci, Uxbridge UB8 3PH, Middx, England.
C3 University of Bedfordshire; Brunel University; Brunel University
RP Yates, JD; Richards, JC (corresponding author), Univ Bedfordshire, Inst Sport & Phys Act Res, Bedford MK41 9EA, England.
EM james.yates8@btinternet.com; jeffrey.aldous@beds.ac.uk;
   daniel.bailey@brunel.ac.uk; angel.chater@beds.ac.uk;
   andrew.mitchell@beds.ac.uk; jo.richards@beds.ac.uk
RI Bailey, Daniel/HDL-7697-2022; Aldous, Jeffrey/HMD-8989-2023
OI Aldous, Jeffrey/0000-0002-9159-4646; Chater, Angel
   Marie/0000-0002-9043-2565; Bailey, Daniel/0000-0003-3772-630X; Richards,
   Joanna/0000-0001-8300-3765
FU Office of the Police and Crime Commissioner at Bedfordshire Police
   [NUT14618]
FX This research was funded through support from the Office of the Police
   and Crime Commissioner at Bedfordshire Police (grant number NUT14618).
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NR 43
TC 8
Z9 9
U1 1
U2 5
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD JUL
PY 2021
VL 18
IS 13
AR 6728
DI 10.3390/ijerph18136728
PG 11
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA TG0QU
UT WOS:000671118800001
PM 34206524
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Goldman-Mellor, SJ
   Caspi, A
   Harrington, H
   Hogan, S
   Nada-Raja, S
   Poulton, R
   Moffitt, TE
AF Goldman-Mellor, Sidra J.
   Caspi, Avshalom
   Harrington, HonaLee
   Hogan, Sean
   Nada-Raja, Shyamala
   Poulton, Richie
   Moffitt, Terrie E.
TI Suicide Attempt in Young People A Signal for Long-term Health Care and
   Social Needs
SO JAMA PSYCHIATRY
LA English
DT Article
ID RISK-FACTORS; MENTAL-HEALTH; ADOLESCENT HEALTH; FOLLOW-UP; PREVALENCE;
   OUTCOMES; BEHAVIORS; MORTALITY; ENGLAND; CHILD
AB IMPORTANCE Suicidal behavior has increased since the onset of the global recession, a trend that may have long-term health and social implications.
   OBJECTIVE To test whether suicide attempts among young people signal increased risk for later poor health and social functioning above and beyond a preexisting psychiatric disorder.
   DESIGN We followed up a cohort of young people and assessed multiple aspects of their health and social functioning as they approached midlife. Outcomes among individuals who had self-reported a suicide attempt up through age 24 years (young suicide attempters) were compared with those who reported no attempt through age 24 years (nonattempters). Psychiatric history and social class were controlled for.
   SETTING AND PARTICIPANTS The population-representative Dunedin Multidisciplinary Health and Development Study, which involved 1037 birth cohort members comprising 91 young suicide attempters and 946 nonattempters, 95% of whom were followed up to age 38 years.
   MAIN OUTCOMES AND MEASURES Outcomes were selected to represent significant individual and societal costs: mental health, physical health, harm toward others, and need for support.
   RESULTS As adults approaching midlife, young suicide attempters were significantly more likely to have persistent mental health problems (eg, depression, substance dependence, and additional suicide attempts) compared with nonattempters. They were also more likely to have physical health problems (eg, metabolic syndrome and elevated inflammation). They engaged in more violence (eg, violent crime and intimate partner abuse) and needed more social support (eg, long-term welfare receipt and unemployment). Furthermore, they reported being lonelier and less satisfied with their lives. These associations remained after adjustment for youth psychiatric diagnoses and social class.
   CONCLUSIONS AND RELEVANCE Many young suicide attempters remain vulnerable to costly health and social problems into midlife. As rates of suicidal behavior rise with the continuing global recession, additional suicide prevention efforts and long-term monitoring and after-care services are needed.
C1 [Goldman-Mellor, Sidra J.] Univ N Carolina, Ctr Dev Sci, Chapel Hill, NC USA.
   [Goldman-Mellor, Sidra J.; Caspi, Avshalom; Harrington, HonaLee; Moffitt, Terrie E.] Duke Univ, Dept Psychol & Neurosci, Durham, NC 27708 USA.
   [Goldman-Mellor, Sidra J.; Caspi, Avshalom; Harrington, HonaLee; Moffitt, Terrie E.] Duke Univ, Inst Genome Sci & Policy, Durham, NC 27708 USA.
   [Goldman-Mellor, Sidra J.; Caspi, Avshalom; Harrington, HonaLee; Moffitt, Terrie E.] Duke Univ, Med Ctr, Dept Psychiat & Behav Sci, Durham, NC 27708 USA.
   [Caspi, Avshalom; Moffitt, Terrie E.] Kings Coll London, Inst Psychiat, Social Genet & Dev Psychiat Ctr, London WC2R 2LS, England.
   [Hogan, Sean; Poulton, Richie] Univ Otago, Dunedin Multidisciplinary Hlth & Dev Res Unit, Dept Prevent & Social Med, Dunedin, New Zealand.
   [Nada-Raja, Shyamala] Univ Otago, Dept Prevent & Social Med, Dunedin, New Zealand.
C3 University of North Carolina; University of North Carolina Chapel Hill;
   Duke University; Duke University; Duke University; University of London;
   King's College London; University of Otago; University of Otago
RP Moffitt, TE (corresponding author), Duke Univ, Dept Psychol & Neurosci, 2020 W Main St,Ste 201,Campus Box 104410, Durham, NC 27708 USA.
EM tem11@duke.edu
RI caspi, avshalom/AAJ-5874-2020; Poulton, Richie/H-2795-2014; Moffitt,
   Terrie/D-5295-2011
OI Moffitt, Terrie/0000-0002-8589-6760
FU New Zealand Health Research Council; US National Institute of Aging
   [AG032282]; UK Medical Research Council [MR/K00381X]; National Institute
   of Child Health and Human Development through the Center for
   Developmental Science, University of North Carolina at Chapel Hill
   [T32-HD07376]; Jacobs Foundation; MRC [MR/K00381X/1] Funding Source:
   UKRI
FX The Dunedin Multidisciplinary Health and Development Research Unit is
   supported by the New Zealand Health Research Council. This study was
   supported by grant AG032282 from the US National Institute of Aging,
   grant MR/K00381X from the UK Medical Research Council, and a
   postdoctoral fellowship provided by the National Institute of Child
   Health and Human Development (T32-HD07376) through the Center for
   Developmental Science, University of North Carolina at Chapel Hill (Dr
   Goldman-Mellor). Additional support was provided by the Jacobs
   Foundation. No other disclosures were reported.
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NR 47
TC 262
Z9 283
U1 2
U2 54
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 2168-622X
EI 2168-6238
J9 JAMA PSYCHIAT
JI JAMA Psychiatry
PD FEB
PY 2014
VL 71
IS 2
BP 119
EP 127
DI 10.1001/jamapsychiatry.2013.2803
PG 9
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA AA8UN
UT WOS:000331370600003
PM 24306041
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Hashem-Dabaghian, F
   Ghods, R
   Shojaii, A
   Abdi, L
   Campos-Toimil, M
   Yousefsani, BS
AF Hashem-Dabaghian, Fataneh
   Ghods, Roshanak
   Shojaii, Asie
   Abdi, Leila
   Campos-Toimil, Manuel
   Yousefsani, Bahareh Sadat
TI Rhus coriaria L., a new candidate for controlling metabolic
   syndrome: a systematic review
SO JOURNAL OF PHARMACY AND PHARMACOLOGY
LA English
DT Review
DE metabolic syndrome; Rhus coriaria L; diabetes mellitus; hypertension;
   hyperlipidaemia; insulin resistance syndrome
ID OXIDATIVE STRESS; PHARMACOLOGICAL-PROPERTIES; INSULIN-RESISTANCE;
   DOUBLE-BLIND; SUMAC; EXTRACT; CHOLESTEROL; POWDER; PLANT; HYPERTENSION
AB Objectives Rhus coriaria L. (RC) is a deciduous shrub with several pharmacological activities. Evidence of the effects of RC on weight, hyperlipidaemia, hypertension and diabetes mellitus have been presented in this study. Books, thesis and internet-based resources such as PubMed, Web of Science, Scopus, EMBASE, Cochrane, Ovid and Google Scholar were searched for the English, Arabic and Persian literature from 1966 to 2020 (December). The keywords were Rhus coriaria L., Sumac, metabolic syndrome and all its medical conditions (hyperlipidaemia, hypertension, obesity and diabetes mellitus). The inclusion criteria were full-text animal and human studies conducted on RC to evaluate its efficacy on any components of metabolic syndrome (MetS). Jadad scale was used to assess the quality of evidence.
   Key findings Reviewing 23 relevant studies demonstrated that RC is able to decrease the level of blood glucose, glycated haemoglobin, serum insulin and insulin resistance. Studies on hyperlipidaemia and obesity have very contradicting results, and there is no definite conclusion on the effect of RC on lipid profile. However, the hypotensive and effect of RC was confirmed in the existing studies.
   Summary According to the literature, RC can be considered as a promising curative candidate for MetS. However, further studies with larger sample size and higher methodological quality are needed.
C1 [Hashem-Dabaghian, Fataneh; Ghods, Roshanak; Shojaii, Asie; Abdi, Leila; Yousefsani, Bahareh Sadat] Iran Univ Med Sci, Res Inst Islamic & Complementary Med, Tehran 1114733311, Iran.
   [Hashem-Dabaghian, Fataneh; Ghods, Roshanak; Shojaii, Asie; Abdi, Leila] Iran Univ Med Sci, Sch Persian Med, Metab Syndrome Res Grp, Tehran, Iran.
   [Campos-Toimil, Manuel] Univ Santiago de Compostela, CIMUS, Physiol & Pharmacol Chron Dis FIFAEC, Santiago De Compostela, Spain.
   [Yousefsani, Bahareh Sadat] Iran Univ Med Sci, Sch Persian Med, Tehran, Iran.
C3 Iran University of Medical Sciences; Iran University of Medical
   Sciences; Universidade de Santiago de Compostela; Iran University of
   Medical Sciences
RP Yousefsani, BS (corresponding author), Iran Univ Med Sci, Res Inst Islamic & Complementary Med, Tehran 1114733311, Iran.
EM yousefsani.b@iums.ac.ir
RI yousefsani, bahare/U-6824-2018; Ghods, Roshanak/D-5424-2018;
   Hashem-Dabaghian, Fataneh/AFA-8635-2022; Shojaii, Asie/T-2733-2019;
   Campos-Toimil, Manuel/C-6164-2011
OI Shojaii, Asie/0000-0002-9093-5525; Campos-Toimil,
   Manuel/0000-0003-3674-3749
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NR 77
TC 0
Z9 0
U1 1
U2 1
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0022-3573
EI 2042-7158
J9 J PHARM PHARMACOL
JI J. Pharm. Pharmacol.
PD JAN
PY 2022
VL 74
IS 1
BP 1
EP 12
DI 10.1093/jpp/rgab120
EA OCT 2021
PG 12
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA YO6XD
UT WOS:000748080800001
DA 2025-06-11
ER

PT J
AU Teychenne, M
   Ball, K
   Salmon, J
AF Teychenne, Megan
   Ball, Kylie
   Salmon, Jo
TI Sedentary Behavior and Depression Among Adults: A Review
SO INTERNATIONAL JOURNAL OF BEHAVIORAL MEDICINE
LA English
DT Review
DE Depression; Mental health; Television; Adult; Internet; Computers
ID TIME PHYSICAL-ACTIVITY; DEPENDENT DIABETES-MELLITUS; TELEVISION VIEWING
   TIME; CORONARY-HEART-DISEASE; LEISURE-TIME; METABOLIC SYNDROME; VIGOROUS
   EXERCISE; INTERNET PARADOX; YOUNG-ADULTS; RISK-FACTORS
AB Background Physically inactive lifestyles and sedentary behaviors (SB) are key contributors to ill health. Although the association between SB (e. g., watching TV/using the computer) and physical health has been well documented, increasing research has focused on the possible link between SB and mental health (e. g., depression).
   Purpose This review aims to investigate the effect of SB on the risk of depression in adults.
   Method A systematic search for original research articles investigating associations between SB and depression in adults was performed using the several electronic data bases.
   Results A total of seven observational and four intervention studies were included in this review. All observational studies found positive associations between SB and risk of depression, while intervention studies showed contradictory results.
   Conclusion Evidence for the relationship between SB and risk of depression in adults is limited by methodological weaknesses. However, on balance, this review suggests that SB is associated with an increased risk of depression. Further studies are needed assessing different types of SB and depression; the interrelationship between physical activity, SB, and depression; causal links between SB and depression; and intervention strategies aimed at reducing SB and their effects on risk of depression.
C1 [Teychenne, Megan; Ball, Kylie; Salmon, Jo] Deakin Univ, Ctr Phys Act & Nutr Res, Sch Exercise & Nutr Sci, Burwood, Vic 3125, Australia.
C3 Deakin University
RP Teychenne, M (corresponding author), Deakin Univ, Ctr Phys Act & Nutr Res, Sch Exercise & Nutr Sci, 221 Burwood Hwy, Burwood, Vic 3125, Australia.
EM mteych@deakin.edu.au
RI Salmon, Jo/X-2630-2019; Ball, Kylie/B-5866-2015; Salmon, Jo/C-1226-2009
OI Salmon, Jo/0000-0002-4734-6354; Teychenne, Megan/0000-0002-7293-8255
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NR 60
TC 350
Z9 397
U1 3
U2 100
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1070-5503
EI 1532-7558
J9 INT J BEHAV MED
JI Int. J. Behav. Med.
PD DEC
PY 2011
VL 17
IS 4
BP 246
EP 254
DI 10.1007/s12529-010-9075-z
PG 9
WC Psychology, Clinical
WE Social Science Citation Index (SSCI)
SC Psychology
GA 762LA
UT WOS:000290478100002
PM 20174982
DA 2025-06-11
ER

PT J
AU Wilson, C
   Nichles, A
   Zmicerevska, N
   Carpenter, JS
   Song, YJC
   McHugh, C
   Hamilton, B
   Hockey, S
   Scott, EM
   Hickie, IB
AF Wilson, Chloe
   Nichles, Alissa
   Zmicerevska, Natalia
   Carpenter, Joanne Sarah
   Song, Yun Ju Christine
   McHugh, Catherine
   Hamilton, Blake
   Hockey, Samuel
   Scott, Elizabeth M.
   Hickie, Ian B.
TI Effect of an online healthy lifestyle psychoeducation programme to
   improve cardiometabolic outcomes and affective symptoms in youth
   receiving mental health care: study protocol for a pilot clinical trial.
SO BMJ OPEN
LA English
DT Article
DE mental health; child & adolescent psychiatry; depression & mood
   disorders; schizophrenia & psychotic disorders
ID 2ND-GENERATION ANTIPSYCHOTIC MEDICATIONS; MAJOR DEPRESSIVE DISORDER;
   SCREENING-TEST ASSIST; PHYSICAL-ACTIVITY; BIPOLAR DISORDER; WEIGHT-GAIN;
   PSYCHOMETRIC EVALUATION; SEDENTARY BEHAVIOR; PREMATURE MORTALITY; EXCESS
   MORTALITY
AB Introduction Worsened cardiometabolic profiles in youth with mental ill health have been associated with a number of modifiable lifestyle risk factors. It is becoming increasingly evident that clinical interventions need to be multimodal in focus to improve mental health symptoms and the physical health symptoms in this already at-risk cohort. Methods and analysis This 12-week pilot clinical trial examines the efficacy, feasibility and acceptability of an adjunctive online psychoeducation programme for improving cardiometabolic risk parameters and affective symptoms in a transdiagnostic sample of at least 44 young people aged 16-25 years presenting for mental healthcare for mood and/or psychotic syndromes (including anxiety, depression, bipolar disorder and psychosis). Individuals will be invited to participate in a pilot clinical trial for a structured online psychoeducation programme incorporating nutritional, physical activity, sleep-wake and healthy lifestyle information, delivered fortnightly over six online modules. Participants will undergo a series of assessments including: (1) self-report and clinician administered assessments determining mental health symptomatology; (2) fasting blood tests to assess cardiometabolic markers (fasting insulin, fasting glucose and blood lipids); (3) anthropometric assessments (height, weight, waist circumference and blood pressure); and (4) sleep-wake behaviours and circadian rhythm assessments. Changes in scores for all cardiometabolic and affective measures will be assessed via paired samples t-tests, and correlations between change scores will be assessed via Pearson's or Spearman's correlations. Feasibility will be assessed via completion rates, and the acceptability of the programme will be assessed via programme satisfaction measures. Ethics and dissemination This pilot clinical trial has been approved by the Sydney Local Health District Research Ethics and Governance Office (X20-0228 & 2020/ETH01201). The results of this pilot clinical trial will be disseminated into the scientific and broader community through peer-reviewed journals, conference presentations, social media and university websites.
C1 [Wilson, Chloe; Nichles, Alissa; Zmicerevska, Natalia; Carpenter, Joanne Sarah; Song, Yun Ju Christine; McHugh, Catherine; Hamilton, Blake; Hockey, Samuel; Scott, Elizabeth M.; Hickie, Ian B.] Univ Sydney, Brain & Mind Ctr, Youth Mental Hlth & Technol Team, Sydney, NSW, Australia.
C3 University of Sydney
RP Wilson, C (corresponding author), Univ Sydney, Brain & Mind Ctr, Youth Mental Hlth & Technol Team, Sydney, NSW, Australia.
EM chloe.wilson@sydney.edu.au
RI Carpenter, Joanne/HZK-3629-2023; Hickie, Ian/K-8975-2015
OI , Chloe/0000-0001-6539-423X; Hockey, Samuel James/0000-0001-8930-6409;
   McHugh, Catherine/0000-0002-4891-4966; Nichles,
   Alissa/0000-0001-6404-7199; Carpenter, Joanne/0000-0002-9766-6700;
   Scott, Elizabeth/0000-0003-3907-0324; Hickie, Ian/0000-0001-8832-9895
FU University of Sydney; National Health & Medical Research Council
   Australia [511921]; Caroline Quinn Research Grant; Liu McCabe Family
   Scholarship
FX This project is an investigator-initiated study, sponsored by the
   University of Sydney and supported by philanthropic funding, for which
   donor(s) are families affected by mental illness who wish to remain
   anonymous. This study was also partially funded by a philanthropic PhD
   scholarship (The Liu McCabe Family Scholarship awarded to CW), a
   National Health & Medical Research Council Australia Fellowship (No.
   511921, awarded to IBH) and a philanthropic fellowship (the Caroline
   Quinn Research Grant awarded to JC).
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NR 118
TC 2
Z9 2
U1 4
U2 14
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2044-6055
J9 BMJ OPEN
JI BMJ Open
PY 2021
VL 11
IS 6
AR e044977
DI 10.1136/bmjopen-2020-044977
PG 10
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA UJ4EO
UT WOS:000691240700014
PM 34187819
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Morelli, NR
   Maes, M
   Bonifacio, KL
   Vargas, HO
   Nunes, SOV
   Barbosa, DS
AF Morelli, Nayara Rampazzo
   Maes, Michael
   Bonifacio, Kamila Landucci
   Vargas, Heber Odebrecht
   Nunes, Sandra Odebrecht Vargas
   Barbosa, Decio Sabbatini
TI Increased nitro-oxidative toxicity in association with metabolic
   syndrome, atherogenicity and insulin resistance in patients with
   affective disorders
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Major depression; Bipolar disorder; Metabolic syndrome; oxidative and
   nitrosative stress; antioxidants biomarkers
ID MAJOR DEPRESSIVE DISORDER; LOW-DENSITY-LIPOPROTEIN; PROTEIN PRODUCTS;
   NITROSATIVE STRESS; MALONDIALDEHYDE; PLASMA; ATHEROSCLEROSIS;
   PEROXYNITRITE; DETERMINANT; BIOMARKERS
AB Background: There is a strong comorbidity between mood disorders and metabolic syndrome (MetS). Increased levels of reactive oxygen and nitrogen species (RONS) and nitro-oxidative stress toxicity (NOSTOX) partially underpin this comorbidity. Aims: To examine the associations of RONS/NOSTOX biomarkers with MetS after adjusting for the significant effects of mood disorders (major depression, and bipolar type 1 and 2), generalized anxiety disorder (GAD), tobacco use disorder (TUD), and male sex. Methods: The study included subjects with (n=65) and without (n=107) MetS and measured levels of superoxide dismutase 1 (SOD1), lipid hydroperoxides (LOOH), nitric oxide metabolites (NOx), malondialdehyde (MDA), and advanced oxidation protein products (AOPP) and computed z unit-weighted composite scores which reflect RONS/NOSTOX. The study included 105 patients with mood disorders, 46 with GAD, and 95 with TUD. Results: MetS was associated with increased levels of MDA and AOPP, independently from mood disorders, TUD, sex and GAD. Atherogenicity and insulin resistance (IR) were significantly associated with a NOSTOX composite score. Mood disorders, TUD, GAD, male sex and MetS independently contribute to increased RONS/NOSTOX. The RONS/NOSTOX profile of MetS was different from that of GAD, which showed increased SOD1 and NOx levels. TUD was accompanied by increased SOD1, LOOH and MDA, and male sex by increased LOOH and AOPP. Conclusions: MetS is characterized by increased lipid peroxidation with aldehyde formation and chlorinative stress, and atherogenicity and IR are strongly mediated by RONS/NOSTOX. Partially shared RONS/NOSTOX pathways underpin the comorbidity of MetS with mood disorders, GAD, and TUD.
C1 [Morelli, Nayara Rampazzo; Maes, Michael; Bonifacio, Kamila Landucci; Vargas, Heber Odebrecht; Nunes, Sandra Odebrecht Vargas; Barbosa, Decio Sabbatini] Univ Estadual Londrina, Hlth Sci Ctr, Hlth Sci Grad Program, Londrina, Parana, Brazil.
   [Maes, Michael] Chulalongkorn Univ, Fac Med, Dept Psychiat, Bangkok, Thailand.
   [Maes, Michael] Med Univ Plovdiv, Dept Psychiat, Plovdiv, Bulgaria.
   [Maes, Michael] Technol Ctr Emergency Med, Plovdiv, Bulgaria.
   [Maes, Michael] Deakin Univ, IMPACT Strateg Res Ctr, Geelong, Vic, Australia.
C3 Universidade Estadual de Londrina; Chulalongkorn University; Medical
   University Plovdiv; Deakin University
RP Maes, M (corresponding author), Chulalongkorn Univ, Fac Med, Dept Psychiat, Bangkok, Thailand.
EM nayara.rampazzo@gmail.com; dr.michaelmaes@hotmail.com;
   kamilalondrina@hotmail.com; hebervargas@sercomtel.com.br;
   sandranunes@sercomtel.com.br; sabbatini2011@hotmail.com
RI Nunes, Sandra/B-4035-2019; Maes, Michael/B-8546-2011
OI Maes, Michael/0000-0002-2012-871X; Rampazzo Morelli,
   Nayara/0000-0001-7183-4668
FU Health Sciences Postgraduate Program at Londrina State University,
   Parana, Brazil (UEL); Ministry for Science and Technology of Brazil
   (CNPq); CNPq [470344/2013-0, 465928/2014-5]; CNPq-PVE fellowship; Health
   Sciences Graduate Program fellowship, State University of Londrina
FX This study was supported by Health Sciences Postgraduate Program at
   Londrina State University, Parana, Brazil (UEL) , and Ministry for
   Science and Technology of Brazil (CNPq) . CNPq number 470344/2013-0 and
   CNPq number 465928/2014-5. MM is supported by a CNPq-PVE fellowship and
   the Health Sciences Graduate Program fellowship, State University of
   Londrina.
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NR 57
TC 20
Z9 20
U1 0
U2 4
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD NOV 1
PY 2021
VL 294
BP 410
EP 419
DI 10.1016/j.jad.2021.07.057
EA JUL 2021
PG 10
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA UK0PQ
UT WOS:000691677800010
PM 34320448
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Bayerle, P
   Haufe, S
   Kück, M
   Protte, G
   Kerling, A
   Ewers, S
   Boeck, HT
   Sundermeier, T
   Ensslen, R
   Kahl, KG
   Haverich, A
   Tegtbur, U
   Nachbar, L
AF Bayerle, Pauline
   Haufe, Sven
   Kueck, Momme
   Protte, Gudrun
   Kerling, Arno
   Ewers, Simone
   Boeck, Hedwig Theda
   Sundermeier, Thorben
   Ensslen, Ralf
   Kahl, Kai G.
   Haverich, Axel
   Tegtbur, Uwe
   Nachbar, Lars
TI The Impact of Body Weight Changes versus Exercise Capacity Changes on
   Health-Related Factors following a Lifestyle Intervention in Employees
   with Metabolic Syndrome
SO NUTRIENTS
LA English
DT Article
DE physical activity; telemonitoring; nutrition; metabolic syndrome;
   company employees; health-related quality of life
ID CARDIOVASCULAR-DISEASE RISK; PRACTICE GUIDELINES; PHYSICAL-ACTIVITY;
   AMERICAN-COLLEGE; OBESITY; ASSOCIATION; MANAGEMENT; POPULATION;
   DEPRESSION; PREVALENCE
AB Background: Lifestyle changes are a cornerstone in the treatment of metabolic syndrome (MetS). However, evidence as to which components of the MetS and associated aspects of quality of life are driven by weight loss or improvements in exercise capacity are scarce. Methods: Company employees (n = 302, 48.2 +/- 8.2 years, BMI 33.2 +/- 5.4 kg/m(2)) with diagnosed MetS were evaluated after a 6-month telemonitoring-supported intervention (counselling in nutrition and physical activity) or wait-list control (delayed start of the same intervention). Results: Exercise capacity, body mass index (BMI), and MetS severity were improved after the intervention. Multivariable regression models revealed that changes in BMI were associated with changes in three components of MetS (waist circumference, triglycerides, blood glucose), whereas changes in exercise capacity only were associated to one MetS component change (systolic blood pressure) but also improvements in anxiety severity, aspects of quality of life, and work ability. Conclusions: Both physical activity promotion and diet should be part of a holistic treatment of patients with MetS. However, our data suggest that dietary-induced weight loss might be more successful when aiming at improving MetS risk factors, whereas focusing more on physical activity promotion might be preferred when targeting aspects in quality of life and mental health.
C1 [Bayerle, Pauline; Haufe, Sven; Kueck, Momme; Protte, Gudrun; Kerling, Arno; Ewers, Simone; Boeck, Hedwig Theda; Sundermeier, Thorben; Tegtbur, Uwe] Hannover Med Sch, Inst Sports Med, D-30625 Hannover, Germany.
   [Ensslen, Ralf; Nachbar, Lars] Volkswagen AG, D-38440 Wolfsburg, Germany.
   [Kahl, Kai G.] Hannover Med Sch, Dept Psychiat Social Psychiat & Psychotherapy, D-30625 Hannover, Germany.
   [Haverich, Axel] Hannover Med Sch, Dept Cardiac Thorac Transplantat & Vasc Surg, D-30625 Hannover, Germany.
C3 Hannover Medical School; Volkswagen; Volkswagen Germany; Hannover
   Medical School; Hannover Medical School
RP Haufe, S (corresponding author), Hannover Med Sch, Inst Sports Med, D-30625 Hannover, Germany.
EM haufe.sven@mh-hannover.de
RI Haverich, Axel/AAC-7552-2022; Haufe, Sven/G-1944-2011
FU Audi BKK health insurance; German Research Foundation through the
   Cluster of Excellence "REBIRTH"
FX This study was supported and funded by grants from Audi BKK health
   insurance and the German Research Foundation through the Cluster of
   Excellence "REBIRTH". The funder of this study had no role in the study
   design, data collection, data analysis, data interpretation, writing of
   the report, or decision to submit for publication. All coauthors had
   access to the raw data if needed. The corresponding author had full
   access to all study data and had final responsibility for the decision
   to submit for publication.
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   World Health Organization (WHO), Obesity and overweight
NR 42
TC 1
Z9 1
U1 1
U2 8
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD NOV
PY 2022
VL 14
IS 21
AR 4560
DI 10.3390/nu14214560
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 6B8KQ
UT WOS:000881576100001
PM 36364823
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Cheng, C
   Wong, WM
   Lai, KC
   Wong, BCY
   Hu, WHC
   Hui, WM
   Lam, SK
AF Cheng, C
   Wong, WM
   Lai, KC
   Wong, BCY
   Hu, WHC
   Hui, WM
   Lam, SK
TI Psychosocial factors in patients with noncardiac chest pain
SO PSYCHOSOMATIC MEDICINE
LA English
DT Article
DE atypical chest pain; coping; noncardiac chest pain; psychosocial
   factors; stress
ID NORMAL CORONARY ARTERIOGRAMS; ISCHEMIC-HEART-DISEASE; SOCIAL SUPPORT;
   PSYCHIATRIC-ILLNESS; SYNDROME-X; COPING PROCESSES; LIFE STRESS;
   DEPRESSION; ANGINA; PERSONALITY
AB Objective: This study sought to explore some psychosocial factors that distinguished individuals with noncardiac chest pain (NCCP) from those without NCCP, and whether these psychosocial factors were associated with anxiety and depression that are co-morbid factors of NCCP. Methods: A matched case-control design was adopted to compare differences in psychosocial factors among a target group of patients with NCCP (N = 70), a pain control,group of patients with rheumatism (N = 70), and a community control group of healthy individuals (N = 70). Results: Compared with subjects from the two control groups, NCCP patients tended to monitor more, use more problem-focused coping, display a coping pattern with a poorer strategy-situation fit, and receive less emotional support in times of stress. Moreover, monitoring perceptual style and problem-focused coping were associated with hi-her levels of anxiety and depression. Coping pattern with a strategy-situation fit and emotional support were related to lower levels of anxiety and depression. Conclusions: The present new findings suggest that monitoring perceptual style and inflexible coping style are risk factors that enhance one's vulnerability to NCCP. Emotional support may be a resource factor that reduces one's susceptibility to NCCP.
C1 Hong Kong Univ Sci & Technol, Div Social Sci, Kowloon, Hong Kong, Peoples R China.
   Univ Hong Kong, Dept Med, Hong Kong, Hong Kong, Peoples R China.
C3 Hong Kong University of Science & Technology; University of Hong Kong
RP Hong Kong Univ Sci & Technol, Div Social Sci, Kowloon, Hong Kong, Peoples R China.
EM c.cheng@ust.hk
RI Wong, Benjamin/C-4436-2009; Cheng, Cecilia/A-2284-2010
OI Cheng, Cecilia/0000-0002-7250-2224
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NR 86
TC 32
Z9 35
U1 0
U2 8
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0033-3174
EI 1534-7796
J9 PSYCHOSOM MED
JI Psychosom. Med.
PD MAY-JUN
PY 2003
VL 65
IS 3
BP 443
EP 449
DI 10.1097/01.PSY.0000041623.24456.99
PG 7
WC Psychiatry; Psychology; Psychology, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry; Psychology
GA 683QH
UT WOS:000183160300017
PM 12764218
DA 2025-06-11
ER

PT J
AU Vinberg, M
   Madsen, M
   Breum, L
   Kessing, LV
   Fink-Jensen, A
AF Vinberg, Maj
   Madsen, Maiken
   Breum, Leif
   Kessing, Lars V.
   Fink-Jensen, Anders
TI Metabolic syndrome in a cohort of affectively ill patients, a
   naturalistic study
SO NORDIC JOURNAL OF PSYCHIATRY
LA English
DT Article
DE Metabolic syndrome; Mood disorder; Prevalence
ID CARDIOVASCULAR-DISEASE; BIPOLAR DISORDER; MENTAL-DISORDER; DEPRESSION;
   MORTALITY; RISK; PREVALENCE
AB Background: Patients with affective disorder have higher mortality not only because of their affective illness but also because of a higher risk of death from physical illness especially cardiovascular diseases. Aim: To investigate the prevalence in a naturalistic cohort of patient treated at a Mood Disorder Clinic. Methods: Patients were evaluated for the presence of metabolic syndrome (MeS) according to modified NCEP ATP III criteria. Results: Of the 143 patients eligible for participation, 100 patients participated in the study (32% male, mean age 43.6 +/- 14.2); the prevalence of MeS was 26%. Higher age and high body mass index (BMI) were significantly associated with MeS. No association between present medication and MeS was seen. Conclusion: More than a quarter of affectively ill patients had MeS, which emphasizes the importance of integrated somatic and psychiatric care in order to reduce this group of patients' risk profile concerning cardiovascular diseases and diabetes. Clinically, it seems reasonable to prioritize overweight and obese patients for further examination.
C1 [Vinberg, Maj; Kessing, Lars V.; Fink-Jensen, Anders] Univ Copenhagen Hosp, Rigshosp, Dept Psychiat, DK-2100 Copenhagen, Denmark.
   [Madsen, Maiken] Univ Copenhagen, Copenhagen, Denmark.
   [Breum, Leif] Koge Hosp, Dept Med, Koge Sygehus, Koge, Denmark.
C3 Rigshospitalet; University of Copenhagen; Copenhagen University
   Hospital; University of Copenhagen
RP Vinberg, M (corresponding author), Univ Copenhagen Hosp, Rigshosp, Dept Psychiat, Blegdamsvej 9, DK-2100 Copenhagen, Denmark.
EM maj.vinberg@regionh.dk
RI Vinberg/ABC-7493-2021; Kessing, Lars/JNS-2493-2023
OI Fink-Jensen, Anders/0000-0001-7143-1236; Kessing,
   Lars/0000-0001-9377-9436; Vinberg, Maj/0000-0002-5982-1335
FU Janssen-Cilag; Eli Lilly; Pfizer
FX MV has been a consultant for Servier and AstraZeneca and has received
   speakers fees from Janssen-Cilag and Eli Lilly, all unrelated to the
   present study.Leif Breum has received speakers fees from Janssen-Cilag,
   Eli Lilly and Pfizer, all unrelated to the present study.
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NR 18
TC 5
Z9 7
U1 0
U2 1
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 0803-9488
J9 NORD J PSYCHIAT
JI Nord. J. Psychiatr.
PD APR
PY 2012
VL 66
IS 2
BP 142
EP 145
DI 10.3109/08039488.2011.595821
PG 4
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 915US
UT WOS:000302053500010
PM 21770840
DA 2025-06-11
ER

PT J
AU Mehdi, S
   Wani, SUD
   Krishna, KL
   Kinattingal, N
   Roohi, TF
AF Mehdi, Seema
   Wani, Shahid Ud Din
   Krishna, K. L.
   Kinattingal, Nabeel
   Roohi, Tamsheel Fatima
TI A review on linking stress, depression, and insulin resistance via
   low-grade chronic inflammation
SO BIOCHEMISTRY AND BIOPHYSICS REPORTS
LA English
DT Review
DE Major depressive disorder; Low-grade chronic inflammation; Chronic
   stress; Insulin resistance; Metabolic syndrome; Neurodegeneration;
   Pharmacological intervention
ID QUALITY-OF-LIFE; PATIENT-REPORTED OUTCOMES; C-REACTIVE PROTEIN;
   METABOLIC SYNDROME; DOUBLE-BLIND; OXIDATIVE STRESS; HEART-RATE;
   CARDIOVASCULAR-DISEASE; MEDITERRANEAN ISLANDS; IMMUNOLOGICAL ASPECTS
AB Stress is a disturbance in homeostasis caused by psychological, physiological, or environmental factors. Prolonged reactions to chronic stress can be detrimental, resulting in various metabolic abnormalities, referred to as metabolic syndrome (MS). There is a reciprocal increased risk between MS and major depressive disorder. Recent studies established an association between inflammation and insulin signaling in type 2 diabetes mellitus with depression. In the present review, we discuss chronic low-grade inflammation, pathways of insulin resistance, and brain glucose metabolism in the context of neuroinflammation and depression. Specific attention is given to psychotropic drugs such as bupropion, mirtazapine, and nefazodone, anti-inflammatory drugs like Celecoxib (COX-2 inhibitor), Etanercept, adalimumab, IL-4Ra antagonist, Anti-IL- 17A antibody (Ixekizumab) and lifestyle modifications including exercise, dietary changes, and sleep hygiene. These therapeutic solutions offer potential in treating depression by targeting metabolic conditions like insulin resistance and inflammatory pathways. The article further explains the significance of a nutrition and antioxidants-rich diet, emphasizing the role of omega-3 fatty acids, vitamin D, zinc, and polyphenols, to improve immunity and activate anti-inflammatory signaling pathways.
C1 [Mehdi, Seema; Krishna, K. L.; Kinattingal, Nabeel; Roohi, Tamsheel Fatima] JSS Acad Higher Educ & Res, JSS Coll Pharm, Dept Pharmacol, Mysore 570015, Karnataka, India.
   [Wani, Shahid Ud Din] Univ Kashmir, Sch Appl Sci & Technol, Dept Pharmaceut Sci, Srinagar 190006, India.
C3 JSS Academy of Higher Education & Research; JSS College of Pharmacy,
   Mysuru; University of Kashmir
RP Mehdi, S; Krishna, KL (corresponding author), JSS Acad Higher Educ & Res, JSS Coll Pharm, Dept Pharmacol, Mysore 570015, Karnataka, India.
EM seemamehdi@jssuni.edu.in; klkrishna@jssuni.edu.in
RI Krishna, Kamsagara/J-9408-2016; Mehdi, Seema/AAY-9912-2020
OI /0000-0002-8785-269X; Kinattingal, Nabeel/0000-0002-2248-3408
CR Aboobacker S., 2023, StatPearls
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NR 149
TC 33
Z9 33
U1 1
U2 8
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2405-5808
J9 BIOCHEM BIOPHYS REP
JI Biochem. Biophys. Rep.
PD DEC
PY 2023
VL 36
AR 101571
DI 10.1016/j.bbrep.2023.101571
EA NOV 2023
PG 13
WC Biochemistry & Molecular Biology
WE Emerging Sources Citation Index (ESCI)
SC Biochemistry & Molecular Biology
GA Z1YS7
UT WOS:001110112300001
PM 37965066
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Carney, R
   Imran, S
   Law, H
   Firth, J
   Parker, S
AF Carney, Rebekah
   Imran, Shermin
   Law, Heather
   Firth, Joseph
   Parker, Sophie
TI Physical health interventions on adolescent mental health inpatient
   units: A systematic review and call to action
SO EARLY INTERVENTION IN PSYCHIATRY
LA English
DT Review
DE adolescent; health services; inpatient; physical health; review
ID CARDIOMETABOLIC RISK-FACTORS; ULTRA-HIGH RISK; METABOLIC SYNDROME;
   YOUNG-PEOPLE; LIFE-STYLE; OUTCOMES; SCHIZOPHRENIA; PSYCHOSIS; CHILDREN;
   ILLNESS
AB Aim Physical health inequalities experienced by people with mental health conditions are labelled an international scandal; due to the 15 to 30-year gap in life expectancy, driven mostly by physical health conditions. Lifestyle interventions are recommended to prevent the onset of poor physical health in people with mental illness. Yet, there is less high-quality evidence for adolescents, particularly those in inpatient settings. We aimed to assess existing literature reporting physical health or lifestyle interventions conducted on adolescent mental health inpatient units.
   Method An electronic search of MEDLINE, PsycINFO, Embase, the Cochrane Central Register of Controlled Trials and AMED was conducted on 13th June 2019. Eligible studies included peer-reviewed English language research articles of physical health interventions delivered within child and adolescent mental health inpatient services. A narrative synthesis was conducted on the data.
   Results Only three studies were identified implementing health interventions for adolescent inpatients. The interventions consisted of two physical health interventions aiming to increase activity levels within routine care (one gym-based, one sports led) and a yoga intervention. Outcome measurements varied and benefits were observed in relation to overall health (HONOSCA), physical health (waist, hip and chest circumference) and behaviour.
   Conclusions Although preliminary results suggest lifestyle interventions may be feasible and beneficial for this group, more work is needed to fully understand the best way to implement these interventions within adolescent clinical settings. Adolescent inpatients are an important target for such interventions, affording the opportunity to prevent the onset of physical comorbidities.
C1 [Carney, Rebekah; Law, Heather; Parker, Sophie] Greater Manchester Mental Hlth NHS Fdn Trust, Youth Mental Hlth Res Unit, Manchester, Lancs, England.
   [Carney, Rebekah; Firth, Joseph; Parker, Sophie] Univ Manchester, Div Psychol & Mental Hlth, Fac Biol Med & Hlth, Manchester, Lancs, England.
   [Imran, Shermin] Greater Manchester Mental Hlth NHS Fdn Trust, Child & Adolescent Mental Hlth Serv, Manchester, Lancs, England.
   [Firth, Joseph] Western Sydney Univ, NICM Hlth Res Inst, Sydney, NSW, Australia.
   [Firth, Joseph] Univ Melbourne, Ctr Youth Mental Hlth, Melbourne, Vic, Australia.
C3 University of Manchester; Western Sydney University; Orygen, The
   National Centre of Excellence in Youth Mental Health; University of
   Melbourne
RP Carney, R (corresponding author), Greater Manchester Mental Hlth NHS Fdn Trust, Youth Mental Hlth Res Unit, Rico House,Bury New Rd, Prestwich M13 3BL, England.
EM rebekah.carney@gmmh.nhs.uk
RI Firth, Joseph/JOZ-1679-2023; Carney, Rebekah/AAO-5205-2021
OI Parker, Sophie/0000-0001-5596-7524; Carney, Rebekah/0000-0002-2859-6825
FU FLF [MR/T021780/1] Funding Source: UKRI
CR [Anonymous], 2018, MANAGEMENT PHYS HLTH
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NR 46
TC 13
Z9 14
U1 0
U2 15
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1751-7885
EI 1751-7893
J9 EARLY INTERV PSYCHIA
JI Early Interv. Psychiatry
PD JUN
PY 2021
VL 15
IS 3
BP 439
EP 448
DI 10.1111/eip.12981
EA MAY 2020
PG 10
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA RV7SA
UT WOS:000533624200001
PM 32426944
OA hybrid
DA 2025-06-11
ER

PT J
AU Puchner, E
   Platzer, M
   Dalkner, N
   Schwalsberger, K
   Lenger, M
   Fellendorf, FT
   Unterrainer, HF
   Schwerdtfeger, A
   Reininghaus, B
   Reininghaus, EZ
AF Puchner, Eva
   Platzer, Martina
   Dalkner, Nina
   Schwalsberger, Karin
   Lenger, Melanie
   Fellendorf, Frederike T.
   Unterrainer, Human-Friedrich
   Schwerdtfeger, Andreas
   Reininghaus, Bernd
   Reininghaus, Eva Z.
TI Effects of Metabolic Syndrome and Sex on Stress Coping Strategies in
   Individuals with Depressive Disorder
SO METABOLITES
LA English
DT Article
DE depression; stress coping strategies; metabolic syndrome; sex;
   distraction strategy
ID GENDER-DIFFERENCES; BIPOLAR DISORDER; RISK-FACTORS; METAANALYSIS;
   STYLES; MORTALITY; INSIGHTS; BEHAVIOR; OBESITY; PEOPLE
AB Metabolic syndrome (MetS) is related to depression and contributes to reduced life expectancy in individuals with mental disorders. Stress coping strategies are important factors in the development and maintenance of depressive disorders and have been related to metabolic disturbances. The aim of this study was to determine whether there is a difference in the use of positive (re- and devaluation, distraction, and control) and negative stress coping strategies in relation to patients' MetS. A sample of 363 individuals (n female = 204, n male = 159) with a diagnosis of depression was measured with the Stress Coping Style Questionnaire and the Beck Depression Inventory. In addition, we collected data on MetS (waist circumference, triglycerides, high-density lipoprotein, fasting glucose/diabetes, blood pressure/hypertonia) according to the International Diabetes Federation. A 2 x 2 design including Mets (with vs. without) and sex (female vs. male) was performed to test for differences in stress coping strategies. Individuals with depression and MetS scored higher on distraction strategies than depressed individuals without MetS (p < 0.01, corrected with false discovery rate). In addition, we found sex differences in stress coping strategies indicating that women with depression scored higher on distraction strategies (p < 0.001, FDR corrected), as well as negative strategies (p < 0.001, FDR corrected), than men. No significant interaction between MetS and sex was found regarding the higher value of stress coping strategies. Findings suggest that individuals with depression and MetS used distraction strategies to a higher amount to cope with stress, which could be stress eating in some cases, than those without MetS. Women with depressive disorders had higher values than men on other coping strategies in our sample of individuals with depression. A better understanding of MetS and sex-specific differences in stress coping strategies might help to plan more effective preventive strategies and personalized treatment options for depression.
C1 [Puchner, Eva; Unterrainer, Human-Friedrich; Schwerdtfeger, Andreas] Karl Franzens Univ Graz, Inst Psychol, A-8010 Graz, Austria.
   [Platzer, Martina; Dalkner, Nina; Schwalsberger, Karin; Lenger, Melanie; Fellendorf, Frederike T.; Unterrainer, Human-Friedrich; Reininghaus, Bernd; Reininghaus, Eva Z.] Med Univ Graz, Dept Psychiat & Psychotherapeut Med, A-8036 Graz, Austria.
   [Unterrainer, Human-Friedrich] Univ Vienna, Inst Religious Studies, A-1010 Vienna, Austria.
   [Unterrainer, Human-Friedrich] Gruner Kreis Soc, Ctr Integrat Addict Res CIAR, A-1110 Vienna, Austria.
   [Unterrainer, Human-Friedrich] Sigmund Freud Univ, Fac Psychotherapy Sci, A-1020 Vienna, Austria.
C3 University of Graz; Medical University of Graz; University of Vienna
RP Unterrainer, HF (corresponding author), Karl Franzens Univ Graz, Inst Psychol, A-8010 Graz, Austria.; Dalkner, N; Unterrainer, HF (corresponding author), Med Univ Graz, Dept Psychiat & Psychotherapeut Med, A-8036 Graz, Austria.; Unterrainer, HF (corresponding author), Univ Vienna, Inst Religious Studies, A-1010 Vienna, Austria.; Unterrainer, HF (corresponding author), Gruner Kreis Soc, Ctr Integrat Addict Res CIAR, A-1110 Vienna, Austria.; Unterrainer, HF (corresponding author), Sigmund Freud Univ, Fac Psychotherapy Sci, A-1020 Vienna, Austria.
EM nina.dalkner@medunigraz.at; human.unterrainer@univie.ac.at
RI Unterrainer, Human/JOQ-2781-2023; Schwerdtfeger, Andreas/U-5317-2019
OI Dalkner, Nina/0000-0001-7716-3674; Schwerdtfeger,
   Andreas/0000-0002-0371-3730; Unterrainer,
   Human-Friedrich/0000-0002-4815-0214; Reininghaus,
   Eva/0000-0001-5964-4087; Fellendorf, Frederike/0000-0001-7215-3848
FU University of Vienna
FX Open Access Funding by the University of Vienna.
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NR 67
TC 1
Z9 1
U1 1
U2 8
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2218-1989
J9 METABOLITES
JI Metabolites
PD MAY 11
PY 2023
VL 13
IS 5
AR 652
DI 10.3390/metabo13050652
PG 13
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA H5RF3
UT WOS:000996526400001
PM 37233693
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Lin, H
   Liu, MX
   Zhong, DM
   Ng, EHY
   Liu, JP
   Li, J
   Shi, Y
   Zhang, CR
   Wen, XH
   Mai, ZF
   Ou, MX
   Ma, HX
AF Lin, Han
   Liu, Mingxing
   Zhong, Dongmei
   Ng, Ernest Hung Yu
   Liu, Jianping
   Li, Juan
   Shi, Yu
   Zhang, Chunren
   Wen, Xiaohui
   Mai, Zhefen
   Ou, Miaoxian
   Ma, Hongxia
TI The Prevalence and Factors Associated With Anxiety-Like and
   Depression-Like Behaviors in Women With Polycystic Ovary Syndrome
SO FRONTIERS IN PSYCHIATRY
LA English
DT Article
DE PCOS; anxiety; depression; hyperandrogenism; metabolic syndrome
ID QUALITY-OF-LIFE; SYNDROME PCOS; DIAGNOSTIC-CRITERIA; RISK; DISORDERS;
   METAANALYSIS; CONSENSUS; GLUCOSE; IMPACT
AB Increasing evidence shows that polycystic ovary syndrome (PCOS) patients are particularly vulnerable to anxiety/depression-like behaviors. This study sought to determine the prevalence of anxiety/depression-like behaviors among women with PCOS and to identify factors associated with these behaviors. This study was a secondary analysis of three studies performed on Chinese women who were aged 18 to 40 and diagnosed with PCOS according to the modified Rotterdam criteria. We obtained 802 useable responses for the self-rating anxiety scale and 798 responses for the self-rating depression scale. The prevalence of anxiety-like and depression-like behaviors among women with PCOS was 26.1% (209/802) and 52.0% (415/798), respectively. Anxiety-like behaviors were associated with age, body image-related factors (including body mass index and waist-to-hip ratio), and hyperandrogenism-related factors (including free androgen index and hirsutism). Depression-like behaviors were associated with age, body image-related factors, hyperandrogenism-related factors, and metabolic factors (including fasting insulin, fasting plasma glucose, and homeostatic model assessment of insulin resistance). Body image-related factors and hyperandrogenism-related factors were related to both anxiety-like behaviors and depression-like behaviors in both infertile and fertile PCOS patients.
C1 [Lin, Han; Li, Juan; Wen, Xiaohui; Mai, Zhefen; Ma, Hongxia] Guangzhou Med Univ, Affiliated Hosp 1, Dept Gynecol Tradit Chinese Med, Guangzhou, Peoples R China.
   [Liu, Mingxing; Shi, Yu; Ou, Miaoxian] Guangzhou Med Univ, Dept Obstet & Gynecol, Affiliated Hosp 3, Guangzhou, Peoples R China.
   [Zhong, Dongmei] Guangzhou Med Univ, Dept Gynecol Tradit Chinese Med, Affiliated Hosp 3, Guangzhou, Peoples R China.
   [Ng, Ernest Hung Yu] Univ Hong Kong, Dept Obstet & Gynecol, Hong Kong, Peoples R China.
   [Liu, Jianping] Beijing Univ Chinese Med, Ctr Evidence Based Chinese Med, Beijing, Peoples R China.
   [Zhang, Chunren] Guangzhou Univ Chinese Med, Guangzhou, Peoples R China.
C3 Guangzhou Medical University; Guangzhou Medical University; Guangzhou
   Medical University; University of Hong Kong; Beijing University of
   Chinese Medicine; Guangzhou University of Chinese Medicine
RP Ma, HX (corresponding author), Guangzhou Med Univ, Affiliated Hosp 1, Dept Gynecol Tradit Chinese Med, Guangzhou, Peoples R China.
EM doctorhongxia@126.com
RI Mai, Zhefen/HJY-6446-2023; Zhang, Congyan/HHC-8442-2022
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NR 51
TC 16
Z9 20
U1 5
U2 30
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-0640
J9 FRONT PSYCHIATRY
JI Front. Psychiatry
PD OCT 20
PY 2021
VL 12
AR 709674
DI 10.3389/fpsyt.2021.709674
PG 12
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA WT6EX
UT WOS:000715957000001
PM 34744814
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Toker, S
   Shirom, A
   Shapira, I
   Berliner, S
   Melamed, S
AF Toker, Sharon
   Shirom, Arie
   Shapira, Itzhak
   Berliner, Shlomo
   Melamed, Samuel
TI The association between burnout, depression, anxiety, and inflammation
   biomarkers: C-reactive protein and fibrinogen in men and women
SO JOURNAL OF OCCUPATIONAL HEALTH PSYCHOLOGY
LA English
DT Review
ID CORONARY-HEART-DISEASE; ATHEROSCLEROTIC VASCULAR-DISEASE; HEALTH-CARE
   PROFESSIONALS; 3RD NATIONAL-HEALTH; RISK-FACTORS;
   CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; VITAL EXHAUSTION;
   GLUCOCORTICOID SENSITIVITY; DISCRIMINANT VALIDITY
AB Following the demonstrated association of employee burnout or vital exhaustion with several risk factors for cardiovascular disease (CVD) and CVD risk, the authors investigated the possibility that one of the mechanisms linking burnout with CVD morbidity is microinflammation, gauged in this study by high-sensitivity C-reactive protein (hs-CRP) and fibrinogen concentrations. Their sample included 630 women and 933 men, all apparently healthy, who underwent periodic health examinations. The authors controlled for possible confounders including 2 other negative affective states: depression and anxiety. In women, burnout was positively associated with hs-CRP and fibrinogen concentrations, and anxiety was negatively associated with them. In men, depression was positively associated with hs-CRP and fibrinogen concentrations, but not with burnout or anxiety. Thus; burnout, depression, and anxiety are differentially associated with microinflammation biomarkers, dependent on gender.
C1 [Shirom, Arie] Tel Aviv Univ, Fac Management, IL-69978 Tel Aviv, Israel.
   [Shapira, Itzhak; Berliner, Shlomo] Tel Aviv Sourasky Med Ctr, Inst Special Med Examinat, Dept Med D, Tel Aviv, Israel.
   [Melamed, Samuel] Natl Inst Occupat & Environm Hlth, Dept Psychol, Raanana, Israel.
   [Melamed, Samuel] Tel Aviv Univ, Sackler Sch Med, IL-69978 Tel Aviv, Israel.
C3 Tel Aviv University; Tel Aviv University; Sackler Faculty of Medicine;
   Tel Aviv Sourasky Medical Center; Tel Aviv University; Sackler Faculty
   of Medicine
RP Toker, S (corresponding author), Tel Aviv Univ, Fac Management, IL-69978 Tel Aviv, Israel.
EM tokersha@post.tau.ac.il; ashirom@post.tau.ac.il
RI Toker, Sharon/P-5428-2015
OI Toker, Sharon/0000-0001-7621-6607
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NR 142
TC 224
Z9 272
U1 0
U2 40
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 1076-8998
EI 1939-1307
J9 J OCCUP HEALTH PSYCH
JI J. Occup. Health Psychol.
PD OCT
PY 2005
VL 10
IS 4
BP 344
EP 362
DI 10.1037/1076-8998.10.4.344
PG 19
WC Public, Environmental & Occupational Health; Psychology, Applied
WE Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; Psychology
GA V43VT
UT WOS:000202963300005
PM 16248685
DA 2025-06-11
ER

PT J
AU Goldstein, JM
   Holsen, L
   Huang, G
   Hammond, BD
   James-Todd, T
   Cherkerzian, S
   Hale, TM
   Handa, RJ
AF Goldstein, Jill M.
   Holsen, Laura
   Huang, Grace
   Hammond, Bradley D.
   James-Todd, Tamarra
   Cherkerzian, Sara
   Hale, Taben M.
   Handa, Robert J.
TI Prenatal stress-immune programming of sex differences in comorbidity of
   depression and obesity/metabolic syndrome
SO DIALOGUES IN CLINICAL NEUROSCIENCE
LA English
DT Article
DE depression; depression-cardiometabolic comorbidity; fetal programming;
   inflammation; obesity/metabolic syndrome; prenatal stress model; sex
   difference
ID PITUITARY-ADRENAL AXIS; ESTROGEN-RECEPTOR-ALPHA; PARAVENTRICULAR
   NUCLEUS; HIPPOCAMPAL VOLUME; HUMAN HYPOTHALAMUS; STEROID-HORMONES;
   IN-VIVO; GLUCOCORTICOID TREATMENT; ANTENATAL BETAMETHASONE;
   INSULIN-RESISTANCE
AB Major depressive disorder (MDD) is the number one cause of disability worldwide and is comorbid with many chronic diseases, including obesity/metabolic syndrome (MetS). Women have twice as much risk for MDD and comorbidity with obesity/MetS as men, although pathways for understanding this association remain unclear. On the basis of clinical and preclinical studies, we argue that prenatal maternal stress (ie, excess glucocorticoid expression and associated immune responses) that occurs during the sexual differentiation of the fetal brain has sex-dependent effects on brain development within highly sexually dimorphic regions that regulate mood, stress, metabolic function, the autonomic nervous system, and the vasculature. Furthermore, these effects have lifelong consequences for shared sex-dependent risk of MDD and obesity/MetS. Thus, we propose that there are shared biologic substrates at the anatomical, molecular, and/or genetic levels that produce the comorbid risk for MDD-MetS through sex-dependent fetal origins. (C) 2016, AICH - Servier Research Group
C1 [Goldstein, Jill M.; Holsen, Laura; James-Todd, Tamarra; Cherkerzian, Sara] Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Connors Ctr Womens Hlth & Gender Biol, Boston, MA USA.
   [Goldstein, Jill M.; Holsen, Laura; Cherkerzian, Sara] Harvard Med Sch, Dept Psychiat, Boston, MA USA.
   [Goldstein, Jill M.; Holsen, Laura; Cherkerzian, Sara] Harvard Med Sch, Dept Med, Boston, MA USA.
   [Huang, Grace] Brigham & Womens Hosp, Dept Med, Div Endocrinol, 75 Francis St, Boston, MA 02115 USA.
   [Hammond, Bradley D.; Hale, Taben M.; Handa, Robert J.] Univ Arizona, Coll Med Phoenix, Dept Basic Med Sci, Phoenix, AZ USA.
   [Hammond, Bradley D.; Handa, Robert J.] Colorado State Univ, Dept Biomed Sci, Ft Collins, CO 80523 USA.
   [James-Todd, Tamarra] Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA.
C3 Harvard University; Harvard University Medical Affiliates; Brigham &
   Women's Hospital; Harvard Medical School; Harvard University; Harvard
   Medical School; Harvard University; Harvard Medical School; Harvard
   University; Harvard University Medical Affiliates; Brigham & Women's
   Hospital; University of Arizona; Colorado State University System;
   Colorado State University Fort Collins; Harvard University; Harvard T.H.
   Chan School of Public Health
RP Goldstein, JM (corresponding author), Brigham & Womens Hosp, Div Womens Hlth, Connors Ctr, One Brigham Circle,1620 Tremont St, Boston, MA 02120 USA.
EM jill_goldstein@hms.harvard.edu
RI Cherkerzian, Sara/MHQ-2272-2025; Holsen, Laura/I-9186-2014
OI Holsen, Laura/0000-0003-1292-7789; Hale, Taben/0000-0002-5066-1216
FU State of Arizona Arizona Biomedical Research Commission (ABRC)
   [ADHS14-00003606]
FX The work for this article was supported by a program project grant from
   the State of Arizona Arizona Biomedical Research Commission (ABRC)
   ADHS14-00003606 (Handa, overall PI; Goldstein, PI, human studies). We
   would like to thank Stuart Tobet, PhD for previous work with us on the
   topic of comorbidity of depression and CVD that forms the basis of some
   of the scientific framework in this review. The authors report no
   conflict of interest.
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NR 158
TC 55
Z9 57
U1 0
U2 14
PU INST CONFERENCE HIPPOCRATE
PI SURESNESS-CEDEX
PA 50 RUE CARNOT, SURESNESS-CEDEX, 92284, FRANCE
SN 1294-8322
EI 1958-5969
J9 DIALOGUES CLIN NEURO
JI Dialogues Clin. Neurosci.
PD DEC
PY 2016
VL 18
IS 4
BP 425
EP 436
PG 12
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology
GA EJ7AQ
UT WOS:000393373600009
PM 28179814
DA 2025-06-11
ER

PT J
AU Chan, KL
   Cathomas, F
   Russo, SJ
AF Chan, Kenny L.
   Cathomas, Flurin
   Russo, Scott J.
TI Central and Peripheral Inflammation Link Metabolic Syndrome and Major
   Depressive Disorder
SO PHYSIOLOGY
LA English
DT Review
ID HIGH-FAT DIET; BLOOD-BRAIN-BARRIER; TUMOR-NECROSIS-FACTOR; MONOCYTE
   CHEMOATTRACTANT PROTEIN-1; GENE-ENVIRONMENT INTERACTION; ADIPOSE-TISSUE;
   BONE-MARROW; INSULIN-RESISTANCE; SKELETAL-MUSCLE; OBESE WOMEN
AB Metabolic syndrome and major depression are two of the most common and debilitating disorders worldwide, occurring with significant rates of comorbidity. Recent studies have uncovered that each of these conditions is associated with chronic, low-grade inflammation. This is characterized by increased circulating pro-inflammatory cytokines, altered leukocyte population frequencies in blood, accumulation of immune cells in tissues including the brain, and activation of these immune cells. Cytokines that become elevated during obesity can contribute to the progression of metabolic syndrome by directly causing insulin resistance. During chronic stress, there is evidence that these cytokines promote depression-like behavior by disrupting neurotransmitter synthesis and signal transduction. Animal models of obesity and depression have revealed a bi-directional relationship whereby high-fat feeding and chronic stress synergize and exacerbate metabolic dysregulation and behavioral abnormalities. Although far from conclusive, emerging evidence suggests that inflammation in the central and peripheral immune system may link metabolic syndrome to major depressive disorder. In this review, we will synthesize available data supporting this view and identify critical areas for future investigation.
C1 [Chan, Kenny L.; Cathomas, Flurin; Russo, Scott J.] Icahn Sch Med Mt Sinai, Dept Neurosci, Ctr Affect Neurosci, New York, NY 10029 USA.
   [Chan, Kenny L.; Cathomas, Flurin; Russo, Scott J.] Icahn Sch Med Mt Sinai, Friedman Brain Inst, New York, NY 10029 USA.
C3 Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at
   Mount Sinai
RP Russo, SJ (corresponding author), Icahn Sch Med Mt Sinai, Dept Neurosci, Ctr Affect Neurosci, New York, NY 10029 USA.
EM scott.russo@mssm.edu
RI Russo, Scott/R-7107-2019
OI Cathomas, Flurin/0000-0002-8274-1317
FU National Institute of Health [RO1 MH-090264, P50 MH-096890, P50
   AT-008661-01, RO1 MH-104559]; Early Postdoc Mobility Fellowship (Swiss
   National Science Foundation); Walter and Gertrud Siegenthaler
   Postdoctoral Fellowship
FX This review was supported by National Institute of Health Grants RO1
   MH-090264, P50 MH-096890 (to S.J.R.), P50 AT-008661-01 (to S.J.R.), RO1
   MH-104559 (to S.J.R.), an Early Postdoc Mobility Fellowship (Swiss
   National Science Foundation), and a Walter and Gertrud Siegenthaler
   Postdoctoral Fellowship (to F.C.).
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NR 145
TC 163
Z9 170
U1 1
U2 46
PU AMER PHYSIOLOGICAL SOC
PI Rockville
PA 6120 Executive Blvd, Suite 600, Rockville, MD, UNITED STATES
SN 1548-9213
EI 1548-9221
J9 PHYSIOLOGY
JI Physiology
PD MAR
PY 2019
VL 34
IS 2
BP 123
EP 133
DI 10.1152/physiol.00047.2018
PG 11
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Physiology
GA HK4EN
UT WOS:000457874300006
PM 30724127
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Knapen, J
   Vancampfort, D
   Moriën, Y
   Marchal, Y
AF Knapen, Jan
   Vancampfort, Davy
   Morien, Yves
   Marchal, Yannick
TI Exercise therapy improves both mental and physical health in patients
   with major depression
SO DISABILITY AND REHABILITATION
LA English
DT Article
DE Depressive disorder; metabolic syndrome; physical therapy
ID CORONARY-HEART-DISEASE; TRANSTHEORETICAL MODEL; ANXIETY; METAANALYSIS;
   DISORDERS; MORTALITY; FITNESS; OBESITY; RISK
AB Purpose: to present clinical guidelines for exercise therapy in depressed patients derived from recent meta-analyses. Method: four meta-analyses on effects of physical exercise on mental and physical in depression were analysed. Results: For mild to moderate depression the effect of exercise may be comparable to antidepressant medication and psychotherapy; for severe depression exercise seems to be a valuable complementary therapy to the traditional treatments. Depression is associated with a high incidence of co-morbid somatic illnesses, especially cardiovascular diseases, type 2 diabetes and metabolic syndrome. Exercise is extremely powerful in preventing and treating these diseases. Physical exercise is an outstanding opportunity for the treatment of patients who have a mix of mental and physical health problems. Exercise therapy also improves body image, patient s coping strategies with stress, quality of life and independence in activities of daily living in older adults. Conclusions: Physical therapists should be aware, that several characteristics of major depression (e.g. loss of interest, motivation and energy, generalised fatigue, a low self-worth and self-confidence, fear to move, and psychosomatic complaints) and physical health problems interfere with participation in exercise. Therefore, motivational strategies should be incorporated in exercise interventions to enhance the patients' motivation and adherence in exercise programs.
C1 [Knapen, Jan; Vancampfort, Davy] Katholieke Univ Leuven, Dept Rehabil Sci, Leuven, Belgium.
   [Knapen, Jan; Marchal, Yannick] Huis Chron Zorg, St Truiden, Belgium.
   [Knapen, Jan; Morien, Yves] AZERTIE, B-3520 Zonhoven, Belgium.
   [Vancampfort, Davy] Univ Psychiat Ctr KU Leuven, Dept Psychomotor Therapy, Kortenberg, Belgium.
   [Marchal, Yannick] Vrije Univ Brussel, Dept Family Med & Chron Care, Brussels, Belgium.
C3 KU Leuven; KU Leuven; Vrije Universiteit Brussel
RP Knapen, J (corresponding author), AZERTIE, Boddenveldweg 11, B-3520 Zonhoven, Belgium.
EM jan.knapen@faber.kuleuven.be
RI Vancampfort, Davy/AAD-1987-2019
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NR 32
TC 246
Z9 282
U1 9
U2 318
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0963-8288
EI 1464-5165
J9 DISABIL REHABIL
JI Disabil. Rehabil.
PY 2015
VL 37
IS 16-17
BP 1490
EP 1495
DI 10.3109/09638288.2014.972579
PG 6
WC Rehabilitation
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Rehabilitation
GA CN7RC
UT WOS:000358630700013
PM 25342564
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Ramírez-Garza, SL
   Laveriano-Santos, EP
   Moreno, JJ
   Bodega, P
   de Cos-Gandoy, A
   de Miguel, M
   Santos-Beneit, G
   Fernández-Alvira, JM
   Fernández-Jiménez, R
   Martínez-Gómez, J
   Ruiz-León, AM
   Estruch, R
   Lamuela-Raventós, RM
   Tresserra-Rimbau, A
AF Ramirez-Garza, Sonia L.
   Laveriano-Santos, Emily P.
   Moreno, Juan J.
   Bodega, Patricia
   de Cos-Gandoy, Amaya
   de Miguel, Mercedes
   Santos-Beneit, Gloria
   Fernandez-Alvira, Juan Miguel
   Fernandez-Jimenez, Rodrigo
   Martinez-Gomez, Jesus
   Ruiz-Leon, Ana Maria
   Estruch, Ramon
   Lamuela-Raventos, Rosa M.
   Tresserra-Rimbau, Anna
TI Metabolic syndrome, adiposity, diet, and emotional eating are associated
   with oxidative stress in adolescents
SO FRONTIERS IN NUTRITION
LA English
DT Article
DE nutritional status; nutrition assessment; fish; refined cereals;
   obesity; emotion; anxiety; depression
ID CARDIOVASCULAR RISK-FACTORS; BODY-MASS INDEX; CENTRAL-NERVOUS-SYSTEM;
   INSULIN-RESISTANCE; SPANISH VERSION; MENTAL-HEALTH; CHILDREN;
   DEPRESSION; 8-ISOPROSTANE; ACTIVATION
AB Background Metabolic syndrome (MS), a condition related to adiposity and oxidative stress, can develop in adolescence, a critical stage in life that impacts health in adulthood. However, there is scarce scientific research about the relationship between lifestyle factors, emotion management, and oxidative stress in this phase of life.
   Aim To analyze whether nutritional parameters, lifestyle factors, emotion management, and MS in adolescents are associated with oxidative stress measured by the biomarker 8-isoprostane.
   Methods A cross-sectional study was carried out in 132 adolescents (48.5% girls, aged 120.48years) and data were collected on nutritional parameters (anthropometric measurements, biochemical analyzes, and blood pressure), lifestyle factors (physical activity, sleep, and diet), and emotion management (self-esteem, emotional eating, and mood). 8-isoprostane was analyzed in spot urine samples. The study population was categorized in three groups (healthy, at-risk, and with MS) using the International Diabetes Federation definition of MS in adolescents. To capture more complex interactions, a multiple linear regression was used to analyze the association between 8-isoprostane and the aforementioned variables.
   Results Urinary 8-isoprostane levels were significantly higher in the MS group compared to the healthy group (1,280 +/- 543pg./mg vs. 950 +/- 416pg./mg respectively). In addition, univariable analysis revealed positive significant associations between 8-isoprostane and body mass index, waist circumference, waist-to-height ratio, body fat percentage, blood lipid profile and glucose, emotional eating, and refined cereal intake. Conversely, a negative significant association was found between 8-isoprostane and sleep duration and fish intake. The multiple linear regression analysis revealed associations between 8-isoprostane and LDL-c (beta=0.173 value of p=0.049), emotional eating (low beta=0.443, value of p=0.036; high beta=0.152, value of p=0.470), refined cereal intake (beta =0.191, value of p=0.024), and fish intake (beta=-0.187, value of p=0.050).
   Conclusion The MS group, LDL-c, emotional eating, and high refined cereals and low fish intakes were associated with higher levels of oxidative stress in an adolescent population.
C1 [Ramirez-Garza, Sonia L.; Laveriano-Santos, Emily P.; Moreno, Juan J.; Lamuela-Raventos, Rosa M.; Tresserra-Rimbau, Anna] Univ Barcelona, Inst Nutr & Food Safety Res, Sch Pharm & Food Sci, Dept Nutr Food Sci & Gastron,XIA, Barcelona, Spain.
   [Laveriano-Santos, Emily P.; Moreno, Juan J.; Ruiz-Leon, Ana Maria; Estruch, Ramon; Lamuela-Raventos, Rosa M.; Tresserra-Rimbau, Anna] Inst Salud Carlos III, Consorcio CIBER, MP Fisiopatol Obesidad Nutr, Madrid, Spain.
   [Bodega, Patricia; de Cos-Gandoy, Amaya; de Miguel, Mercedes; Santos-Beneit, Gloria] Fdn Sci Hlth & Educ, Barcelona, Spain.
   [Bodega, Patricia; de Cos-Gandoy, Amaya; de Miguel, Mercedes; Fernandez-Alvira, Juan Miguel; Fernandez-Jimenez, Rodrigo; Martinez-Gomez, Jesus] Ctr Nacl Invest Cardiovasc, Madrid, Spain.
   [Santos-Beneit, Gloria] Icahn Sch Med Mt Sinai, Zena & Michael Wiener Cardiovasc Inst, New York, NY USA.
   [Fernandez-Jimenez, Rodrigo] Hosp Univ Clin San Carlos, Madrid, Spain.
   [Fernandez-Alvira, Juan Miguel] Ctr Invest Biomed Red Enfermedades Cardiovasc, Madrid, Spain.
   [Estruch, Ramon] Univ Barcelona, Inst Invest Biomed August Pi &Sunyer, Hosp Clin, Dept Internal Med, Barcelona, Spain.
C3 University of Barcelona; Instituto de Salud Carlos III; Centro Nacional
   de Investigaciones Cardiovasculares (CNIC); Icahn School of Medicine at
   Mount Sinai; CIBER - Centro de Investigacion Biomedica en Red; CIBERCV;
   University of Barcelona; Hospital Clinic de Barcelona; IDIBAPS
RP Tresserra-Rimbau, A (corresponding author), Univ Barcelona, Inst Nutr & Food Safety Res, Sch Pharm & Food Sci, Dept Nutr Food Sci & Gastron,XIA, Barcelona, Spain.; Tresserra-Rimbau, A (corresponding author), Inst Salud Carlos III, Consorcio CIBER, MP Fisiopatol Obesidad Nutr, Madrid, Spain.
EM annatresserra@ub.edu
RI Raventos, Rosa/F-3986-2016; Martínez Gómez, Jesús/HKF-7276-2023; de Cos,
   Amaya/KEJ-5787-2024; Tresserra-Rimbau, Anna/ABD-1099-2020; Fernandez,
   Rodrigo/AFV-4674-2022; Estruch, Ramon/AAZ-3723-2020; Fernández-Alvira,
   Juan/O-9665-2019; Ruiz-Leon, Ana Maria/HTS-8184-2023; Moreno,
   Juan/AAA-1312-2019; Santos-Beneit, Gloria/E-4652-2019; LAVERIANO SANTOS,
   EMILY/AFX-6417-2022
OI RAMIREZ-GARZA, SONIA L./0000-0001-6337-100X; de Cos-Gandoy,
   Amaya/0000-0003-4799-0147; Santos-Beneit, Gloria/0000-0002-3979-7067;
   LAVERIANO SANTOS, EMILY/0000-0002-4852-6074; Martinez Gomez,
   Jesus/0000-0002-7770-073X
FU SHE Foundation; la Caixa Foundation [100010434, LCF/PR/CE16/10700001,
   LCF/PR/MS19/12220001]; Fundacio la Marato de TV3 [369/C/2016];
   Ministerio de Ciencia, Innovacion y Universidades
   [PID2020-114022RB-I00]; CIBEROBN from the Instituto de Salud Carlos III
   (ISCIII) from the Ministerio de Ciencia, Innovacion y Universidades
   (AEI/FEDER, UE); Generalitat de Catalunya; ISCIII; Ministerio de Ciencia
   e Innovacion (MCIN); Pro CNIC Foundation; MICIN/AEI [CEX2020-001041-S];
   MICIN/AEI/FEDER, UE [CEX2021-001234-M]; ISCIII [PI22/01560]; European
   Union; Generalitat de Catalunya [EMC/503/2021]; Ministerio de Educacion,
   Cultura y Deporte [FPU21/04891]
FX The authors especially thank all the volunteers and their families,
   teachers, and schools for their contribution to the SI! Program for
   Secondary Schools. The authors thank the SHE Foundation (intellectual
   owner of the SI! Program) and its partners Isabel Carvajal, Domenec
   Haro, Xavier Orrit, Carla Rodriguez, Vanessa Carral, Rosa Casas,
   Carolina E. Storniolo, for their contribution to the study design,
   coordination, development, and all personnel who performed measurements
   in adolescents at participating schools. The SI! Program for Secondary
   Schools trial was supported by the SHE Foundation, the la Caixa
   Foundation (LCF/PR/CE16/10700001), the Fundacio la Marato de TV3 (grant
   number 369/C/2016). Support was also provided by the Ministerio de
   Ciencia, Innovacion y Universidades (PID2020-114022RB-I00), CIBEROBN
   from the Instituto de Salud Carlos III (ISCIII) from the Ministerio de
   Ciencia, Innovacion y Universidades (AEI/FEDER, UE), and Generalitat de
   Catalunya. The CNIC is supported by the ISCIII, the Ministerio de
   Ciencia e Innovacion (MCIN) and the Pro CNIC Foundation, and is a Severo
   Ochoa Center of Excellence (grant CEX2020-001041-S funded by
   MICIN/AEI/10.13039/501100011033), and INSA-UB a Maria de Maeztu Center
   of Excellence (grant CEX2021-001234-M funded by MICIN/AEI/FEDER, UE).
   RF-J is recipient of grant PI22/01560 funded by the ISCIII and co-funded
   by the European Union. GS-B was the recipient of grant
   LCF/PR/MS19/12220001 funded by la Caixa Foundation (ID 100010434). AT-R
   is a Serra Hunter fellow. EL-S was a FI-SDUR (EMC/503/2021) fellowship
   from the Generalitat de Catalunya. JM-G is a recipient of grant
   FPU21/04891 (Ayudas para la formacion de profesorado universitario,
   FPU-2021) from the Ministerio de Educacion, Cultura y Deporte.
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NR 91
TC 5
Z9 5
U1 3
U2 11
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PY 2023
VL 10
AR 1216445
DI 10.3389/fnut.2023.1216445
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA IZ6O9
UT WOS:001170208600001
PM 37789897
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Wang, PW
   Kuo, HM
   Huang, HT
   Chang, AYW
   Weng, SW
   Tai, MH
   Chuang, JH
   Chen, IY
   Huang, SC
   Lin, TK
   Liou, CW
AF Wang, Pei-Wen
   Kuo, Hsiao-Mei
   Huang, Hung-Tu
   Chang, Alice Y. W.
   Weng, Shao-Wen
   Tai, Ming-Hong
   Chuang, Jiin-Haur
   Chen, I-Ya
   Huang, Shun-Chen
   Lin, Tsu-Kung
   Liou, Chia-Wei
TI Biphasic Response of Mitochondrial Biogenesis to Oxidative Stress in
   Visceral Fat of Diet-Induced Obesity Mice
SO ANTIOXIDANTS & REDOX SIGNALING
LA English
DT Article
ID INSULIN-RESISTANCE SYNDROME; SUBCUTANEOUS ADIPOSE-TISSUE; TYPE-2
   DIABETES-MELLITUS; C-REACTIVE PROTEIN; METABOLIC SYNDROME; CHRONIC
   INFLAMMATION; NONALCOHOLIC STEATOHEPATITIS; CARDIOVASCULAR-DISEASE;
   CARDIOMETABOLIC RISK; GLUCOSE-METABOLISM
AB Aims: Studies in skeletal muscle demonstrate a strong association of mitochondrial dysfunction with insulin resistance (IR). However, there is still a paucity of knowledge regarding the alteration of mitochondria in adipose tissue (AT) in the pathogenesis of IR in obesity. We investigated the mitochondrial biogenesis in visceral fat (VF) and subcutaneous fat (SF) in C57BL/6J mice fed a high-fat high-sucrose diet for 12 months. Results: Impairment of glucose tolerance and insulin sensitivity developed after 1 month of the diet and was associated with a prompt increase of VF. The VF adipocytes were larger than those in the SF and had increased expressions of HIF-1 and p-NFB p65. However, the alteration of mitochondrial biogenesis did not occur in the early stage when increased intracellular reactive oxygen species (ROS), mitochondrial oxygen consumption rate, and mitochondrial ROS emerged at the 1st, 2nd and 2nd month, respectively. Until the 6th month, the VF had markedly increased mitochondrial DNA content and expression of PGC-1, Tfam, ATP5A, and MnSOD. This increase of mitochondrial biogenesis was followed by a generalized decrease at the 12th month and the mitochondrial morphology altered markedly. In the late stage, although mitochondrial ROS decreased, the increased expression of 8-OHdG in VF continued. Innovation and Conclusion: These data suggest that IR and ROS production occur before the biphasic changes of mitochondrial biogenesis in AT, and the VF plays a more crucial role. Antioxid. Redox Signal. 20, 2572-2588.
C1 [Wang, Pei-Wen; Kuo, Hsiao-Mei; Weng, Shao-Wen; Chen, I-Ya] Chang Gung Univ, Coll Med, Dept Internal Med, Kaohsiung Chang Gung Mem Hosp, Kaohsiung 83301, Taiwan.
   [Huang, Hung-Tu] Kaohsiung Med Univ, Sch Med, Coll Med, Dept Anat, Kaohsiung, Taiwan.
   [Chang, Alice Y. W.] Chang Gung Univ, Coll Med, Ctr Translat Res Biomed Sci, Kaohsiung Chang Gung Mem Hosp, Kaohsiung 83301, Taiwan.
   [Tai, Ming-Hong] Natl Sun Yat Sen Univ, Dept Biol Sci, Inst Biomed Sci, Kaohsiung 80424, Taiwan.
   [Chuang, Jiin-Haur] Chang Gung Univ, Coll Med, Dept Surg, Kaohsiung Chang Gung Mem Hosp, Kaohsiung 83301, Taiwan.
   [Huang, Shun-Chen] Chang Gung Univ, Coll Med, Dept Anat Pathol, Kaohsiung Chang Gung Mem Hosp, Kaohsiung 83301, Taiwan.
   [Lin, Tsu-Kung; Liou, Chia-Wei] Chang Gung Univ, Coll Med, Dept Neurol, Kaohsiung Chang Gung Mem Hosp, Kaohsiung 83301, Taiwan.
C3 Chang Gung Memorial Hospital; Chang Gung University; Kaohsiung Medical
   University; Chang Gung University; Chang Gung Memorial Hospital;
   National Sun Yat Sen University; Chang Gung Memorial Hospital; Chang
   Gung University; Chang Gung University; Chang Gung Memorial Hospital;
   Chang Gung Memorial Hospital; Chang Gung University
RP Lin, TK (corresponding author), Chang Gung Univ, Coll Med, Dept Neurol, Kaohsiung Chang Gung Mem Hosp, 123 Ta Pei Rd, Kaohsiung 83301, Taiwan.
EM tklin@adm.cgmh.org.tw; cwliou@ms22.hinet.net
RI Weng, Shape wen/GYU-9746-2022; Tsai, Ming/ABA-9806-2020; Chen,
   Shih-Hong/AAG-1525-2021
FU National Science Council (Republic of China) [NSC-96-2628-B-182-001-MY2,
   98-2314-B-182-007-MY3]; Chang Gung University College of Medicine and
   Kaohsiung Chang Gung Memorial Hospital [CMRPG850263, CMRPG891111,
   CMRPG891112, CMRPG891113]
FX This work was supported by grants NSC-96-2628-B-182-001-MY2 and
   98-2314-B-182-007-MY3 from the National Science Council (Republic of
   China) and grants CMRPG850263, CMRPG891111, CMRPG891112, and CMRPG891113
   from the Chang Gung University College of Medicine and Kaohsiung Chang
   Gung Memorial Hospital. The authors are grateful to Miss Shui-Chin Lu
   and Miss Huey-Ju Lee for their technical assistance in transmission
   electron microscopy.
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NR 63
TC 30
Z9 32
U1 0
U2 15
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1523-0864
EI 1557-7716
J9 ANTIOXID REDOX SIGN
JI Antioxid. Redox Signal.
PD JUN 1
PY 2014
VL 20
IS 16
BP 2572
EP 2588
DI 10.1089/ars.2013.5334
PG 17
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA AG9SM
UT WOS:000335760000007
PM 24111683
OA Green Published
DA 2025-06-11
ER

PT J
AU Di Giuseppe, M
   Conversano, C
AF Di Giuseppe, Mariagrazia
   Conversano, Ciro
TI Psychological components of chronic diseases: the link between defense
   mechanisms and alexithymia
SO MEDITERRANEAN JOURNAL OF CLINICAL PSYCHOLOGY
LA English
DT Article
DE Chronic diseases; Psychosomatics; Emotion regulation; Alexithymia;
   Defense mechanisms
ID METABOLIC SYNDROME; CANCER-PATIENTS; BREAST-CANCER; CHRONIC PAIN;
   DEPRESSION; CHILDHOOD; HEALTH; IMPACT; PERSONALITY; STRESS
C1 [Di Giuseppe, Mariagrazia] Univ Roma Tor Vergata, Dept Hist Culture & Soc, Rome, Italy.
   [Conversano, Ciro] Univ Pisa, Dept Surg Med & Mol Pathol, Crit & Care Med, Pisa, Italy.
C3 University of Rome Tor Vergata; University of Pisa
RP Di Giuseppe, M (corresponding author), Univ Roma Tor Vergata, Dept Hist Culture & Soc, Rome, Italy.
EM mariagrazia.di.giuseppe@uniroma2.it
RI Di+Giuseppe, Mariagrazia/AFK-3211-2022; Conversano, Ciro/ABE-1007-2020
OI Di Giuseppe, Mariagrazia/0000-0002-0373-4523
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NR 83
TC 18
Z9 18
U1 0
U2 7
PU UNIV STUDI MESSINA
PI MESSINA
PA VIA DEI VERDI, MESSINA, 98122, ITALY
SN 2282-1619
J9 MEDITERR J CLIN PSYC
JI Mediterr. J. Clin. Psychol.
PY 2022
VL 10
IS 3
BP 27
EP 27
DI 10.13129/2282-1619/mjcp-3602
PG 1
WC Psychology, Clinical
WE Emerging Sources Citation Index (ESCI)
SC Psychology
GA 7M8CA
UT WOS:000906878200003
DA 2025-06-11
ER

PT J
AU Magnavita, N
AF Magnavita, Nicola
TI Headache in the Workplace: Analysis of Factors Influencing Headaches in
   Terms of Productivity and Health
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Article
DE anxiety; depression; metabolic syndrome; leadership; effort; reward;
   sleep; workplace health promotion; medical surveillance; headache
   disorders
ID PSYCHOSOCIAL FACTORS; RISK-FACTORS; NECK PAIN; WORK; MIGRAINE; STRESS;
   IMPACT; ENVIRONMENTS; INSTRUMENT; MANAGEMENT
AB Headache is a very common condition that can have a significant impact on work. This study aimed to assess the prevalence of headaches and their impact on a sample of 1076 workers from 18 small companies operating in different sectors. The workers who volunteered to participate were asked to fill in the Headache Impact Test-6 (HIT-6) and answer questions designed to assess stressful and traumatic factors potentially associated with headaches. The volunteers subsequently underwent a medical examination and tests for diagnosing metabolic syndrome. Out of the 1044 workers who completed the questionnaire (participation rate = 97%), 509 (48.8%) reported suffering from headaches. In a multivariate logistic regression model, female gender, recent bereavement, intrusive leadership, and sleep problems were significantly associated with headaches. In univariate logistic regression models, headache intensity was associated with an increased risk of anxiety (OR 1.10; CI95% 1.09; 1.12) and depression (OR 1.09; CI95% 1.08; 1.11). Headache impact was also associated with the risk of metabolic syndrome (OR 1.02; CI95% 1.00, 1.04), obesity (OR 1.02, CI95% 1.01; 1.03), and reduced HDL cholesterol (OR 1.03; CI95% 1.01; 1.04). The impact of headache calls for intervention in the workplace not only to promote a prompt diagnosis of the different forms of headaches but also to improve work organization, leadership style, and the quality of sleep.
C1 [Magnavita, Nicola] Univ Cattolica Sacro Cuore, Postgrad Sch Occupat Hlth, Largo F Vito 1, I-00168 Rome, Italy.
   [Magnavita, Nicola] A Gemelli Fdn IRCCS, Dept Sci Woman Child & Publ Hlth, Largo A Gemelli 8, I-00168 Rome, Italy.
C3 Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli
RP Magnavita, N (corresponding author), Univ Cattolica Sacro Cuore, Postgrad Sch Occupat Hlth, Largo F Vito 1, I-00168 Rome, Italy.; Magnavita, N (corresponding author), A Gemelli Fdn IRCCS, Dept Sci Woman Child & Publ Hlth, Largo A Gemelli 8, I-00168 Rome, Italy.
EM nicolamagnavita@gmail.com
RI Magnavita, Nicola/J-6074-2014
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NR 89
TC 21
Z9 22
U1 1
U2 6
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD MAR
PY 2022
VL 19
IS 6
AR 3712
DI 10.3390/ijerph19063712
PG 11
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA 0C6XF
UT WOS:000775453200001
PM 35329399
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Richter, N
   Juckel, G
   Assion, HJ
AF Richter, N.
   Juckel, G.
   Assion, H. -J.
TI Metabolic syndrome: a follow-up study of acute depressive inpatients
SO EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
LA English
DT Article
DE Depression; Metabolic syndrome; Triglycerides
ID YOUNG-ADULTS; PREVALENCE; POPULATION; SYMPTOMS; HEALTH
AB Previous studies pointed out the high prevalence of the metabolic syndrome among patients with bipolar disorder and major depression. A link between depression and a metabolic syndrome remains in dispute despite these studies. This study was conducted to evaluate the occurrence of the metabolic syndrome in depressive inpatients, to analyze the association between the severity of depression and the metabolic syndrome and to screen specific laboratory values in the course of depressive illness. 60 acute depressive patients were recruited for the study and underwent psychometric testing [21-item Hamilton Depression Rating Scale (HAMD), Beck Depression Inventory (BDI), Clinical Global Impression Scale (CGI) and Global Assessment of Functioning Scale (GAF)] and a metabolic syndrome screening using the modified criteria of the American National Cholesterol Education Program (NCEP) Treatment Panel III (ATP III). Moreover, CRP, cholesterol, HDL-cholesterol, fasting glucose, triglyceride and leptin levels were measured. 42 patients were reexamined in state of (partial) remission. Depression was reassessed using the 21-item HAMD, and laboratory values were analyzed a second time. 25% of the depressive patients fulfilled the criteria of metabolic syndrome (MS+). Only in the MS+ group, a positive correlation between triglyceride blood levels and severity of depression became evident as well in the state of acute depression as in the state of remission. In the group of patients without metabolic syndrome, laboratory values were not associated with severity of depression. An association between metabolic parameters and the course of depression could only be detected in the group of patients with metabolic syndrome. These findings suggest that, in these patients, a beneficial outcome of depressive illness may improve the metabolic situation.
C1 [Richter, N.; Juckel, G.; Assion, H. -J.] Ruhr Univ Bochum, Dept Psychiat & Psychotherapy, LWL Hosp Bochum, D-44791 Bochum, Germany.
C3 Ruhr University Bochum
RP Assion, HJ (corresponding author), Ruhr Univ Bochum, Dept Psychiat & Psychotherapy, LWL Hosp Bochum, Alexandrinenstr 1, D-44791 Bochum, Germany.
EM assion-hj@versanet.de
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NR 21
TC 44
Z9 49
U1 0
U2 4
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0940-1334
EI 1433-8491
J9 EUR ARCH PSY CLIN N
JI Eur. Arch. Psych. Clin. Neurosci.
PD FEB
PY 2010
VL 260
IS 1
BP 41
EP 49
DI 10.1007/s00406-009-0013-5
PG 9
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Psychiatry
GA 534AS
UT WOS:000272868500005
PM 19399357
DA 2025-06-11
ER

PT J
AU Hollander, PA
   Amod, A
   Litwak, LE
   Chaudhari, U
AF Hollander, Priscilla A.
   Amod, Aslam
   Litwak, Leon E.
   Chaudhari, Umesh
CA ARPEGGIO Study Grp
TI Effect of Rimonabant on Glycemic Control in Insulin-Treated Type 2
   Diabetes: The ARPEGGIO Trial
SO DIABETES CARE
LA English
DT Article
ID CANNABINOID-1 RECEPTOR BLOCKER; CARDIOMETABOLIC RISK-FACTORS;
   OBESE-PATIENTS; BODY-WEIGHT; EFFICACY; OVERWEIGHT
AB OBJECTIVE - To examine the efficacy and safety of rimonabant, a selective cannabinoid receptor type-1 antagonist, in patients with type 2 diabetes receiving insulin monotherapy.
   RESEARCH DESIGN AND METHODS - Patients (n = 368; A1C >= 7%) were randomized to 20 mg/day rimonabant or placebo in this 48-week, double-blind, placebo-controlled I multicenter trial. Change in baseline A1C to week 48 (primary outcome) and changes in body weight, waist circumference, and lipid levels (secondary outcomes) were assessed.
   RESULTS - Rimonabant significantly reduced baseline A1C versus placebo (-0.89 vs. -0.24% P < 0.0001), and significantly greater improvements were observed in cardiometabolic risk factors. More rimonabant. Patients achieved >10% reduction in mean total daily insulin dose versus placebo (P = 0.0012), and fewer required rescue medication (P < 0.0001). Hypoglycemia, nausea, dizziness, anxiety, and depression were more frequent with rimonabant.
   CONCLUSIONS - Rimonabant improved glycerine control and cardiometabolic risk factors in patients with type 2 diabetes receiving insulin.
C1 [Hollander, Priscilla A.] Baylor Univ, Med Ctr, Dallas, TX USA.
   [Amod, Aslam] Chatsmed Garden Hosp, Ctr Diabet Endocrinol & Metab Dis, Durban, South Africa.
   [Litwak, Leon E.] Hosp Italiano Buenos Aires, Buenos Aires, DF, Argentina.
   [Chaudhari, Umesh] Sanofi Aventis US, Bridgewater, NJ USA.
C3 Baylor University; Baylor University Medical Center; University of
   Buenos Aires; University of Buenos Aires Hospital; Hospital Italiano de
   Buenos Aires; Sanofi-Aventis; Sanofi USA
RP Hollander, PA (corresponding author), Baylor Univ, Med Ctr, Dallas, TX USA.
EM priscilh@baylorhealth.edu
FU sanofi-aventis; Roche; Novo Nordisk
FX This article was supported by sanofi-aventis.P.A.H. has served on the
   advisory boards for sanofi-aventis, Pfizer, Novo Nordisk, and Merck; is
   a consultant for Orexigen, Sankyo, and Pfizer; is on the speakers bureau
   for Pfizer, Merck, and sanofi-aventis; has received research support
   only as part Of Multicenter clinical trials. A.A. has received honoraria
   from sanofi-aventis and has served on the advisory boards for MSD, Eli
   Lilly, Servier, and Novartis. L.E.L. has served on the advisory boards
   for sanofi-aventis, Roche, Pfizer, Eli Lilly, Novo Nordisk, and
   Novartis; is a board member for Eli Lilly and sanofi-aventis; has
   received research support from Roche, sanofi-aventis, and Novo Nordisk.
   U.C. is an employee of sanofi-aventis U.S. No other potential conflicts
   of interest relevant to this article were reported.
CR Bloomgarden ZT, 2006, DIABETES CARE, V29, P2137, DOI 10.2337/dc06-1120
   Christensen R, 2007, LANCET, V370, P1706, DOI 10.1016/S0140-6736(07)61721-8
   DESPRES JP, 2007, 67 SCI SESS AM DIAB
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NR 14
TC 38
Z9 43
U1 0
U2 2
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0149-5992
EI 1935-5548
J9 DIABETES CARE
JI Diabetes Care
PD MAR
PY 2010
VL 33
IS 3
BP 605
EP 607
DI 10.2337/dc09-0455
PG 3
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 568YO
UT WOS:000275562700030
PM 20009090
OA Green Submitted, hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Glaus, J
   Vandeleur, C
   Gholam-Rezaee, M
   Castelao, E
   Perrin, M
   Rothen, S
   Bovet, P
   Marques-Vidal, P
   von Känel, R
   Merikangas, K
   Mooser, V
   Waterworth, DM
   Waeber, G
   Vollenweider, P
   Preisig, M
AF Glaus, J.
   Vandeleur, C.
   Gholam-Rezaee, M.
   Castelao, E.
   Perrin, M.
   Rothen, S.
   Bovet, P.
   Marques-Vidal, P.
   von Kaenel, R.
   Merikangas, K.
   Mooser, V.
   Waterworth, D. M.
   Waeber, G.
   Vollenweider, P.
   Preisig, M.
TI Atypical depression and alcohol misuse are related to the cardiovascular
   risk in the general population
SO ACTA PSYCHIATRICA SCANDINAVICA
LA English
DT Article
DE depression; substance use disorders; weight gain; risk factors;
   cardio-vascular diseases
ID TEST-RETEST RELIABILITY; CORONARY-HEART-DISEASE; GENETIC-STUDIES DIGS;
   PSYCHIATRIC-DISORDERS; DIAGNOSTIC INTERVIEW; ANXIETY DISORDERS;
   MENTAL-HEALTH; OBESITY; SYMPTOMS; ASSOCIATION
AB ObjectiveThe aims of the present study were to assess the associations between mood, anxiety and substance use disorders, including their subtypes, and the prevalence of cardiovascular risk factors (CVRFs).
   MethodThorough physical investigations, biological measures and standardized interview techniques were used to assess 3716 subjects of an urban area, aged 35-66 years.
   ResultsAtypical depression was associated with increased prevalence of overweight, diabetes and the metabolic syndrome (OR=1.5, 95% C.I. 1.1-2.0; OR=2.0, 95% C.I. 1.1-3.5, OR=1.6, 95% C.I. 1.0-2.4 respectively), whereas decreased prevalence of overweight was found in melancholic (OR=0.7, 95% C.I. 0.6-0.9) and unspecified depression (OR=0.8, 95% C.I. 0.7-1.0). Alcohol abuse was associated with diabetes (OR=1.8, 95% C.I. 1.1-2.9) and dyslipidemia (OR=1.3, 95% C.I. 1.0-1.8), alcohol dependence with dyslipidemia only (OR=1.4, 95% C.I. 1.0-2.0). Almost all mental disorders were associated with a lifetime history of regular cigarette smoking, and atypical depression, alcohol misuse and drug dependence were associated with inactivity.
   ConclusionTo conclude results emphasize the need to subtype depression and to pay particular attention to the atypical subtype. Comorbid alcohol misuse may further increase the cardiovascular risk. Efforts to diminish smoking in subjects with mental disorders could be crucial measures to reduce their high incidence of cardiovascular disease.
C1 [Glaus, J.; Vandeleur, C.; Gholam-Rezaee, M.; Castelao, E.; Perrin, M.; Rothen, S.; Preisig, M.] Univ Lausanne Hosp, Dept Psychiat, Lausanne, Switzerland.
   [Bovet, P.; Marques-Vidal, P.] Univ Lausanne Hosp, Inst Social & Prevent, Lausanne, Switzerland.
   [von Kaenel, R.] Univ Hosp Bern, Dept Gen Internal Med, CH-3010 Bern, Switzerland.
   [Merikangas, K.] NIMH, Genet Epidemiol Res Branch, Intramural Res Program, Bethesda, MD 20892 USA.
   [Mooser, V.; Waterworth, D. M.] GlaxoSmithKline, Med Genet, Philadelphia, PA USA.
   [Waeber, G.; Vollenweider, P.] Univ Lausanne Hosp, Dept Internal Med, Lausanne, Switzerland.
C3 University of Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV);
   University of Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV);
   University of Bern; University Hospital of Bern; National Institutes of
   Health (NIH) - USA; NIH National Institute of Mental Health (NIMH);
   GlaxoSmithKline; Glaxosmithkline USA; University of Lausanne; Centre
   Hospitalier Universitaire Vaudois (CHUV)
RP Glaus, J (corresponding author), Univ Lausanne Hosp, Dept Psychiat, Ctr Res Psychiat Epidemiol & Psychopathol CEPP, Site Cery, CH-1008 Prilly, Switzerland.
EM jennifer.glaus@chuv.ch
RI Preisig, Martin/H-3441-2016; Rothen, Stephane/E-8325-2014; Glaus,
   Jennifer/C-7887-2017; von Kanel, Roland/B-1811-2019; Marques-Vidal,
   Pedro/C-9449-2009; Vollenweider, Peter/Q-4603-2016; Bovet,
   Pascal/F-4477-2011
OI Glaus, Jennifer/0000-0001-8883-9473; Preisig,
   Martin/0000-0001-5689-4259; von Kanel, Roland/0000-0002-8929-5129;
   Castelao, Enrique/0000-0003-1966-3683; Marques-Vidal,
   Pedro/0000-0002-4548-8500; Vandeleur, Caroline/0000-0001-9092-6648;
   Vollenweider, Peter/0000-0002-0765-896X; Merikangas,
   Kathkeen/0000-0002-4667-2414; Bovet, Pascal/0000-0002-0242-4259; Waeber,
   Gerard/0000-0003-4193-788X
FU Swiss National Science Foundation [32003B-105993, 32003B-118308,
   33CSC0-122661]; GlaxoSmithKline Clinical Genetics; Swiss National
   Science Foundation (SNF) [33CSC0-122661] Funding Source: Swiss National
   Science Foundation (SNF)
FX The authors express their gratitude to the Lausanne inhabitants who
   volunteered to participate in the PsyCoLaus study and to the
   collaborators who contributed to the coordination of the study and the
   collection of data. They also thank all the investigators of the CoLaus
   study, who made the psychiatric study possible, as well as many GSK
   employees who contributed to the execution of this study. This research
   was supported by three grants from the Swiss National Science Foundation
   (#32003B-105993, #32003B-118308 and #33CSC0-122661 to M. Preisig) and
   two grants from GlaxoSmithKline Clinical Genetics to G. Waeber, P.
   Vollenweider and M. Preisig. The funding organization played no role in
   the design or conduct of the study, the collection, management,
   analysis, or interpretation of the data; or the preparation, review, or
   approval of the manuscript.
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NR 62
TC 55
Z9 59
U1 0
U2 10
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0001-690X
EI 1600-0447
J9 ACTA PSYCHIAT SCAND
JI Acta Psychiatr. Scand.
PD OCT
PY 2013
VL 128
IS 4
BP 282
EP 293
DI 10.1111/acps.12057
PG 12
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 224WQ
UT WOS:000324922700006
PM 23216242
DA 2025-06-11
ER

PT J
AU McCurley, JL
   Penedo, F
   Roesch, SC
   Isasi, CR
   Carnethon, M
   Sotres-Alvarez, D
   Schneiderman, N
   Gonzalez, P
   Chirinos, DA
   Camacho, A
   Teng, YP
   Gallo, LC
AF McCurley, Jessica L.
   Penedo, Frank
   Roesch, Scott C.
   Isasi, Carmen R.
   Carnethon, Mercedes
   Sotres-Alvarez, Daniela
   Schneiderman, Neil
   Gonzalez, Patricia
   Chirinos, Diana A.
   Camacho, Alvaro
   Teng, Yanping
   Gallo, Linda C.
TI Psychosocial Factors in the Relationship between Socioeconomic Status
   and Cardiometabolic Risk: the HCHS/SOL Sociocultural Ancillary Study
SO ANNALS OF BEHAVIORAL MEDICINE
LA English
DT Article
DE Cardiovascular; Hispanic; Latino; Metabolic syndrome; Psychosocial;
   Socioeconomic status
ID CORONARY-HEART-DISEASE; RESERVE CAPACITY MODEL; MEXICAN-AMERICAN WOMEN;
   METABOLIC SYNDROME; CARDIOVASCULAR-DISEASE; HEALTH; LATINOS;
   HISPANICS/LATINOS; DISPARITIES; PREVALENCE
AB U.S. Hispanics/Latinos display a high prevalence of metabolic syndrome (MetSyn), a group of co-occurring cardiometabolic risk factors (abdominal obesity, impaired fasting glucose, dyslipidemia, elevated blood pressure) associated with higher cardiovascular disease and mortality risk. Low socioeconomic status (SES) is associated with higher risk for MetSyn in Hispanics/Latinos, and psychosocial factors may play a role in this relationship.
   This cross-sectional study examined psychosocial factors in the association of SES and MetSyn components in 4,996 Hispanic/Latino adults from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) Sociocultural Ancillary Study.
   MetSyn components were measured at the baseline examination. Participants completed interviews to determine psychosocial risks (e.g., depression) and resources (e.g., social support) within 9 months of baseline (< 4 months in 72.6% of participants). Confirmatory factor analysis (CFA) and structural equation modeling (SEM) were used to identify latent constructs and examine associations.
   Participant mean age was 41.7 years (SE = 0.4) and 62.7% were female. CFA identified single latent factors for SES and psychosocial indicators, and three factors for MetSyn [blood pressure, lipids, metabolic factors]. SEMs showed that lower SES was related to MetSyn factors indirectly through higher psychosocial risk/lower resources (Y-B chi(2) (df = 420) = 4412.90, p < .05, RMSEA = .042, SRMR = .051). A statistically significant effect consistent with mediation was found from lower SES to higher metabolic risk (glucose/waist circumference) via psychosocial risk/resource variables (Mackinnon's 95% asymmetric CI = -0.13 to -0.02).
   SES is related to metabolic variables indirectly through psychosocial factors in U.S. Hispanics/Latinos of diverse ancestries.
C1 [McCurley, Jessica L.] Univ Calif San Diego, San Diego State Univ, San Diego Joint Doctoral Program Clin Psychol, San Diego, CA 92103 USA.
   [Penedo, Frank] Northwestern Univ, Dept Med Social Sci, Chicago, IL 60611 USA.
   [Roesch, Scott C.; Gallo, Linda C.] San Diego State Univ, Dept Psychol, San Diego, CA 92182 USA.
   [Isasi, Carmen R.] Albert Einstein Coll Med, Deptartment Epidemiol & Populat Hlth, Bronx, NY 10467 USA.
   [Carnethon, Mercedes] Northwestern Univ, Feinberg Sch Med, Dept Prevent Med, Chicago, IL 60611 USA.
   [Sotres-Alvarez, Daniela] Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Biostat, Collaborat Studies Coordinating Ctr, Chapel Hill, NC USA.
   [Schneiderman, Neil; Chirinos, Diana A.] Univ Miami, Dept Psychol, POB 248185, Coral Gables, FL 33124 USA.
   [Gonzalez, Patricia] San Diego State Univ, Grad Sch Publ Hlth, San Diego, CA 92182 USA.
   [Camacho, Alvaro] Univ Calif San Diego, Dept Psychiat, San Diego, CA 92103 USA.
   [Camacho, Alvaro] Univ Calif San Diego, Dept Family Med & Publ Hlth, San Diego, CA 92103 USA.
   [Teng, Yanping] Univ North Carolina Chapel Hill, Gillings Sch Publ Hlth, Dept Biostat, Chapel Hill, NC USA.
   [Gallo, Linda C.] South Bay Latino Res Ctr, 450 4th Ave,Suite 304, Chula Vista, CA 91910 USA.
C3 University of California System; University of California San Diego;
   California State University System; San Diego State University;
   Northwestern University; California State University System; San Diego
   State University; Montefiore Medical Center; Albert Einstein College of
   Medicine; Yeshiva University; Northwestern University; Feinberg School
   of Medicine; University of North Carolina; University of North Carolina
   Chapel Hill; University of Miami; California State University System;
   San Diego State University; University of California System; University
   of California San Diego; University of California System; University of
   California San Diego; University of North Carolina; University of North
   Carolina Chapel Hill; University of North Carolina School of Medicine
RP Gallo, LC (corresponding author), San Diego State Univ, Dept Psychol, San Diego, CA 92182 USA.; Gallo, LC (corresponding author), South Bay Latino Res Ctr, 450 4th Ave,Suite 304, Chula Vista, CA 91910 USA.
EM lgallo@mail.sdsu.edu
RI González, Patricia/F-3822-2016; Sotres-Alvarez, Daniela/O-9085-2016
OI Carnethon, Mercedes/0000-0001-7035-0848; Gallo, Linda
   C./0000-0002-3678-5888
FU National Heart, Lung, and Blood Institute [75, N01-HC65233, N01-HC65234,
   N01-HC65235, N01-HC65236, N01-HC65237]; NIH/NHLBI [1 RC2 HL101649]; NIH
   [5T32HL079891-06]; GloCal Health Fellowship - Fogarty International
   Center; NHLBI; University of California Global Health Institute [R25
   TW009343]
FX The Hispanic Community Health Study/Study of Latinos was supported by
   contracts from the National Heart, Lung, and Blood Institute (75) to the
   University of North Carolina (N01-HC65233), University of Miami
   (N01-HC65234), Albert Einstein College of Medicine (N01-HC65235),
   Northwestern University (N01-HC65236), and San Diego State University
   (N01-HC65237). The following Institutes/Centers/ Offices contribute to
   the HCHS/SOL through a transfer of funds to the NHLBI: National
   Institute on Minority Health and Health Disparities, National Institute
   on Deafness and Other Communication Disorders, National Institute of
   Dental and Craniofacial Research, National Institute of Diabetes and
   Digestive and Kidney Diseases, National Institute of Neurological
   Disorders and Stroke, Office of Dietary Supplements. The HCHS/SOL
   Sociocultural Ancillary Study was supported by grant 1 RC2 HL101649 from
   the NIH/NHLBI (Gallo/Penedo PIs). Author Jessica L. McCurley was
   additionally supported by an NIH T32 training grant in Cardiovascular
   Epidemiology from the NHLBI and UC San Diego (5T32HL079891-06) and a
   GloCal Health Fellowship funded by the Fogarty International Center,
   NHLBI, and the University of California Global Health Institute (R25
   TW009343).
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NR 74
TC 18
Z9 25
U1 1
U2 11
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0883-6612
EI 1532-4796
J9 ANN BEHAV MED
JI Ann. Behav. Med.
PD AUG
PY 2017
VL 51
IS 4
BP 477
EP 488
DI 10.1007/s12160-016-9871-z
PG 12
WC Psychology, Multidisciplinary
WE Social Science Citation Index (SSCI)
SC Psychology
GA FF1YF
UT WOS:000408694400001
PM 28130624
OA Bronze, Green Accepted
DA 2025-06-11
ER

PT J
AU Wulsin, LR
   Blom, TJ
   Durling, M
   Welge, JA
   DelBello, MP
   Adler, CM
   McNamara, RK
   Strakowski, SM
AF Wulsin, Lawson R.
   Blom, Thomas J.
   Durling, Michelle
   Welge, Jeffrey A.
   DelBello, Melissa P.
   Adler, Caleb M.
   McNamara, Robert K.
   Strakowski, Stephen M.
TI Cardiometabolic risks and omega-3 index in recent-onset bipolar I
   disorder
SO BIPOLAR DISORDERS
LA English
DT Article
DE bipolar disorder; glucose; metabolic syndrome; omega-3 fatty acids;
   triglycerides
ID POLYUNSATURATED FATTY-ACIDS; MAJOR DEPRESSIVE DISORDER;
   CORONARY-HEART-DISEASE; CEREBRAL-BLOOD-FLOW; DRUG-NAIVE PATIENTS;
   C-REACTIVE PROTEIN; CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME;
   INSULIN-RESISTANCE; RATING-SCALE
AB ObjectivesMethodsThe aims of the present study were to characterize cardiometabolic risk factors in a cohort of bipolar disorder patients with limited exposure to psychotropic medications, and to evaluate their associations with mood symptoms and omega-3 polyunsaturated fatty acid (PUFA) blood levels.
   Cardiometabolic risk assessments were compared in individuals with bipolar I disorder experiencing a first manic or mixed episode or an early depressive episode (n=117) and healthy subjects (n=56). Patients were medication free at assessment and had no or limited exposure to mood-stabilizer or antipsychotic medications prior to the current admission. Associations among cardiometabolic parameters and Clinical Global ImpressionSeverity scale (CGI-S), manic (Young Mania Rating Scale [YMRS]), and depressive (Hamilton Depression Rating Scale [HDRS]) symptom ratings were evaluated within the bipolar group.
   ResultsConclusionsFollowing adjustment for demographic variables (i.e., age, gender, and parental education), significantly higher fasting triglyceride levels were observed in the bipolar group compared to the healthy group (121.7mg/dL vs 87.0mg/dL; P<.01). There were no clear trends for other metabolic indicators, including blood pressure, body mass index, and fasting glucose. Nineteen percent of the bipolar group and 6% of the healthy group met the criteria for metabolic syndrome (P=.23). The omega-3 index was lower in the bipolar group (3.4% vs 3.9%; P<.01). Within the bipolar group, no associations were found between the cardiometabolic parameters and CGI-S, YMRS, and HDRS symptom ratings.
   Recent-onset medication-free bipolar disorder is associated with higher triglyceride levels. These findings are suggestive of early metabolic dysregulation prior to long-term psychotropic medication exposure. Lower omega-3 PUFA levels in individuals with bipolar I disorder represent a potential therapeutic target for additional investigation.
C1 [Wulsin, Lawson R.; Blom, Thomas J.; Durling, Michelle; Welge, Jeffrey A.; DelBello, Melissa P.; Adler, Caleb M.; McNamara, Robert K.; Strakowski, Stephen M.] Univ Cincinnati, Coll Med, Dept Psychiat & Behav Neurosci, Div Bipolar Disorders Res, Cincinnati, OH USA.
C3 University System of Ohio; University of Cincinnati
RP Wulsin, LR (corresponding author), Univ Cincinnati, Coll Med, Dept Psychiat & Behav Neurosci, Cincinnati, OH 45220 USA.
EM lawson.wulsin@uc.edu
RI McNamara, Robert/J-4309-2014
OI McNamara, Robert/0000-0002-9703-8114
FU Center for Scientific Review [DK097599, P50 MH077138]
FX Center for Scientific Review, Grant/Award Number: DK097599 and P50
   MH077138
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NR 55
TC 10
Z9 11
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1398-5647
EI 1399-5618
J9 BIPOLAR DISORD
JI Bipolar Disord.
PD NOV
PY 2018
VL 20
IS 7
BP 658
EP 665
DI 10.1111/bdi.12633
PG 8
WC Clinical Neurology; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA GY8AW
UT WOS:000448841100010
PM 29479787
DA 2025-06-11
ER

PT J
AU Pelluri, R
   Kongara, S
   Chimakurthy, J
   Mahadevan, S
   Nagasubramanian, V
AF Pelluri, Ranakishor
   Kongara, Srikanth
   Chimakurthy, Jithendra
   Mahadevan, Shriraam
   Nagasubramanian, Vanitharani
TI The role of body mass index or metabolic syndrome components causing
   depression in women: An observation from weight reduction clinical trial
SO JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS
LA English
DT Article
DE body mass index; insulin resistance; metabolic syndrome; PHQ-9 scale
ID HOMEOSTASIS MODEL ASSESSMENT; INSULIN-RESISTANCE; ASSOCIATION; OBESITY;
   ANXIETY
AB What is known and objective Depression is most important psychological problem that is much prevalent in women than men. Obesity and depression are the leading causes of both physical and mental disability and the link between these disorders had not explored well. The present study evaluated the link between the depression, Body mass index (BMI) and the components of metabolic syndrome (MetS) in subjects with, without insulin resistance. Methods A total of 150 subjects, vital and biochemical parameters were measured for eligible screened subjects in the trial of weight loss intervention at first visit. A self-reported Patient Health Questionnaire (PHQ-9) scale was used to assess the depression among the participants. The association of BMI and MetS components with risk of depression was analysed using multiple logistic regression analysis in subjects with and without insulin resistance. Results Obesity was associated with highly significant increase in risk of depression (OR = 13.01, 95% CI 4.40-38.49) as compared to overweight subjects. Female subjects with obesity had a greater risk for depression (beta: 3.725, OR: 42.62, 95% CI: 5.74-316.3 and p < 0.0001) than male subjects (beta: 1.922, OR: 6.83, 95% CI: 1.8-26 and p = 0.005), and it was statistically significant. There was no association between other models (IR and MetS) and depression in both genders (p < 0.05). What is new and conclusion The odds of depression was 42.62 times more in obese women and 6.83 time more in obese men compared to overweight subjects. Subjects those who are having >= 3 metabolic syndrome (MetS) components, increased the risk of depression by 0.75 times in women and 1.50 times in men. In view of these results of our study, we conclude that the body mass index is an individual strong predictor of depression whereas metabolic syndrome and insulin resistance had no significant association with depression.
C1 [Pelluri, Ranakishor] Vignan Pharm Coll, Dept Pharm Practice, Guntur 522213, Andhra Pradesh, India.
   [Pelluri, Ranakishor; Kongara, Srikanth] Endo Life Special Hosp, Dept Endocrinol & Metab, Guntur, Andhra Pradesh, India.
   [Pelluri, Ranakishor; Mahadevan, Shriraam] Sri Ramachandra Inst Higher Educ & Res Deemed Uni, Dept Pharm Practice, Chennai, Tamil Nadu, India.
   [Chimakurthy, Jithendra] Vignans Fdn Sci Technol & Res Deemed Univ, Dept Pharmaceut Sci, Guntur 522213, Andhra Pradesh, India.
   [Mahadevan, Shriraam; Nagasubramanian, Vanitharani] Sri Ramachandra Inst Higher Educ & Res Deemed Uni, Sri Ramachandra Med Coll & Res Inst, Dept Endocrinol & Metab, Chennai, Tamil Nadu, India.
C3 Sri Ramachandra Institute of Higher Education & Research; Vignan's
   Foundation for Science, Technology & Research (VFSTR); Sri Ramachandra
   Institute of Higher Education & Research
RP Nagasubramanian, V (corresponding author), Sri Ramachandra Inst Higher Educ & Res Deemed Uni, Dept Pharm Practice, Chennai, Tamil Nadu, India.
EM vanitharani.n@sriramachandra.edu.in
RI Mahadevan, Shriraam/AAP-3706-2020; Chimakurthy, Jithendra/AAZ-2859-2020;
   Nagasubramanian, Vanitha Rani/ABD-2871-2021; Pelluri M.Pharm, Ph.D, Dr.
   Ranakishor/AGA-5904-2022
OI Pelluri M.Pharm, Ph.D, Dr. Ranakishor/0000-0002-0478-4848; Mahadevan,
   Shriraam/0000-0002-6915-5639; JITHENDRA,
   CHIMAKURTHY/0000-0002-2948-4948; Kongara, Dr.
   Srikanth/0000-0002-9291-6096; NAGASUBRAMANIAN, VANITHA
   RANI/0000-0001-8390-4870
CR Agarwal A, 2016, INDIAN J PSYCHIAT, V58, P281, DOI 10.4103/0019-5545.192021
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NR 26
TC 4
Z9 4
U1 1
U2 5
PU WILEY-HINDAWI
PI LONDON
PA ADAM HOUSE, 3RD FL, 1 FITZROY SQ, LONDON, WIT 5HE, ENGLAND
SN 0269-4727
EI 1365-2710
J9 J CLIN PHARM THER
JI J. Clin. Pharm. Ther.
PD DEC
PY 2021
VL 46
IS 6
BP 1757
EP 1763
DI 10.1111/jcpt.13522
EA SEP 2021
PG 7
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA WW8MK
UT WOS:000693887600001
PM 34490636
OA gold
DA 2025-06-11
ER

PT J
AU AlKhathami, AD
   Alamin, MA
   Alqahtani, AM
   Alsaeed, WY
   AlKhathami, MA
   Al-Dhafeeri, AH
AF AlKhathami, Abdullah D.
   Alamin, Mohamed A.
   Alqahtani, Areej M.
   Alsaeed, Wafaa Y.
   AlKhathami, Mohammed A.
   Al-Dhafeeri, Abdulazeez H.
TI Depression and anxiety among hypertensive and diabetic primary health
   care patients Could patients' perception of their diseases
   control be used as a screening tool?
SO SAUDI MEDICAL JOURNAL
LA English
DT Article
ID METABOLIC SYNDROME; PREVALENCE; ASSOCIATION; OUTPATIENTS; SEVERITY;
   SYMPTOMS
AB Objectives: To measure the frequency and identify risk factors of depression and anxiety among diabetic and hypertensive primary health care (PHC) patients. Also to assess whether patients' perception of their chronic diseases control and sleep disturbance could serve as screening tools for depression and anxiety.
   Methods: This cross-sectional study of 368 PHC patients was conducted in AlKhobar city, Kingdom of Saudi Arabia between April and May 2015. Patient Health Questionnaire-9 and Generalized Anxiety Disorder-7 were used as diagnostic tools for depression and anxiety.
   Results: Frequencies, cross-tabulations and logistic regression tests were performed. Patient's perception of chronic diseases control was significantly associated with the presence of depression and anxiety, while it was not seen in the tested disease control (glycated hemoglobin <7% and blood pressure <140/90 mm Hg). Sleep disturbance has a high specificity (98.9%) in screening for depression. Overall prevalence of depression or anxiety was 57.3% and detected cases was 23%. Depression comprise 48.7% (39.8% mild, 7.1% moderate, 1.8% severe). Anxiety comprise 38.4% (25.1% mild, 8.8% moderate, 4.4% severe). Co-existence of both disorders was 29.5%. Sleep disturbance, weight change, and low income had an independent significant effect on depression and anxiety.
   Conclusion: Having no sleep disturbance can rule out 98.9% of depression and anxiety cases. Patient's feelings should be considered in chronic diseases health care plans. Depression or anxiety among diabetic and hypertensive patients have a high morbidity, but with low detection rate.
C1 [AlKhathami, Abdullah D.; Alamin, Mohamed A.; Alqahtani, Areej M.] Minist Hlth, Saudi Post Grad Family Med Program, Al Khobar, Eastern Provinc, Saudi Arabia.
   [Alsaeed, Wafaa Y.] AlKhobar Hlth Ctr Adm, Al Khobar, Eastern Provinc, Saudi Arabia.
   [AlKhathami, Mohammed A.; Al-Dhafeeri, Abdulazeez H.] Minist Hlth, Al Khobar, Eastern Provinc, Saudi Arabia.
C3 Ministry of Health - Saudi Arabia; Ministry of Health - Saudi Arabia
RP Alamin, MA (corresponding author), Minist Hlth, Saudi Post Grad Family Med Program, Eastern Alkhobar, Saudi Arabia.
EM mohamedali.alamin@gmail.com
RI Abdelhamid, Mohamed/JTS-4149-2023
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NR 36
TC 41
Z9 47
U1 0
U2 4
PU SAUDI MED J
PI RIYADH
PA ARMED FORCES HOSPITAL, PO BOX 7897,, RIYADH 11159, SAUDI ARABIA
SN 0379-5284
J9 SAUDI MED J
JI Saudi Med. J.
PD JUN
PY 2017
VL 38
IS 6
BP 621
EP 628
DI 10.15537/smj.2017.6.17941
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA EY8CX
UT WOS:000404223100008
PM 28578442
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Siervo, M
   Wells, JCK
   Cizza, G
AF Siervo, Mario
   Wells, Jonathan C. K.
   Cizza, Giovanni
TI Evolutionary theories, psychosocial stress and the modern obesity
   epidemic
SO OBESITY AND METABOLISM-MILAN
LA English
DT Review
DE human evolution; seasonality; stress response; visceral adiposity
ID BODY-MASS INDEX; ACTIVATED PROTEIN-KINASE; WORK STRESS;
   SOCIOECONOMIC-STATUS; SECULAR TRENDS; INDUSTRIAL-REVOLUTION; NUTRITION
   TRANSITION; AGONISTIC BEHAVIOR; METABOLIC SYNDROME; THRIFTY GENOTYPES
AB The thrifty genotype hypothesis of Neel theorises that a set of genes have been selected during evolution to confer an adaptive advantage. In modern times, characterized by unlimited food availability, these genes may have become metabolically harmful and may be contributing to the secular trends in weight gain and epidemic of type 2 diabetes and metabolic syndrome. These genes remain to be identified. We suggest the existence of cellular energy sensing mechanisms controlling the regulation of energy balance and we hypothesise the existence of different physiological pathways regulating anabolic or catabolic pathways. We propose that the adaptive energetic and neuro-endocrine responses that have characterized the evolution of the Homo genus exposed to uncertainty in energy supply can be explained by models of conservation of energy based upon the laws of thermodynamics. We have applied these models to modern humans to shed some light on the increased prevalence in obesity. Fluctuations in the availability of food, due to environmental and climatic perturbations, were most likely strong selective forces for the transmission of genes important for survival. However, in modern times where changes in food availability due to seasonality are attenuated, the decrease in physical activity and increase in energy intake, features of our times, are not conferring a selective advantage. Modern times are characterized by increased emotional stress and decreased sleep duration and the consequent activation of the hypothalamic-pituitary-adrenal axis, and sympatho-adrenal system which, in turn, may induce accumulation of visceral fat and metabolic syndrome. We propose that the neuroendocrine stress system evolved to enhance chances of survival for our ancestors, but in today's plentifully provisioned societies, where sedentariness and mental stress have become typical traits of modem humans, the chronic activation of the stress responses may underpin some of the metabolic characteristics of the insulin resistance syndrome.
C1 [Siervo, Mario] Elsie Widdowson Lab, MRC Human Nutr Res, Cambridge CB1 9NL, England.
   [Wells, Jonathan C. K.] Inst Child Hlth, Childrens Nutr Res Ctr, London, England.
   [Cizza, Giovanni] NIDDK, NIH, Bethesda, MD USA.
C3 UK Research & Innovation (UKRI); Medical Research Council UK (MRC); MRC
   Human Nutrition Research; University of London; University College
   London; National Institutes of Health (NIH) - USA; NIH National
   Institute of Diabetes & Digestive & Kidney Diseases (NIDDK)
RP Siervo, M (corresponding author), Elsie Widdowson Lab, MRC Human Nutr Res, Fulbourn Rd, Cambridge CB1 9NL, England.
EM Mario.Siervo@mrc-hnr.cam.ac.uk
RI Siervo, Mario/AAB-9302-2019; Wells, Jonathan/A-4604-2009
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NR 134
TC 6
Z9 6
U1 0
U2 20
PU EDITRICE KURTIS S R L
PI MILAN
PA VIA LUIGI ZOJA 30, 20153 MILAN, ITALY
SN 1825-3865
EI 1826-7572
J9 OBES METAB-MILAN
JI Obes. Metab.-Milan
PD JUN
PY 2008
VL 4
IS 2
BP 131
EP 142
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 339HO
UT WOS:000258568900008
DA 2025-06-11
ER

PT J
AU Gurusamy, J
   Gandhi, S
   Damodharan, D
   Palaniappan, M
   Ganesan, V
AF Gurusamy, Jothimani
   Gandhi, Sailaxmi
   Damodharan, Dinakaran
   Palaniappan, Marimuthu
   Ganesan, Venkatasubramanian
TI Effect of lifestyle modification intervention (LMI) on metabolic
   syndrome in schizophrenia in a residential mental health care setting-A
   mixed method study
SO SCHIZOPHRENIA RESEARCH
LA English
DT Article
ID PEOPLE; RISK; INDIVIDUALS; FACILITATORS; BARRIERS; SUPPORT
C1 [Gurusamy, Jothimani] Natl Inst Mental Hlth & Neuro Sci NIMHANS, Coll Nursing, Bengaluru, India.
   [Gandhi, Sailaxmi] Natl Inst Mental Hlth & Neuro Sci NIMHANS, Dept Nursing, Bengaluru, India.
   [Damodharan, Dinakaran] Natl Inst Mental Hlth & Neuro Sci NIMHANS, Ctr Psychosocial Support & Disaster Management, Bangalore, India.
   [Palaniappan, Marimuthu] Natl Inst Mental Hlth & Neuro Sci NIMHANS, Dept Biostat, Bangalore, India.
   [Ganesan, Venkatasubramanian] Natl Inst Mental Hlth & Neuro Sci NIMHANS, Dept Psychiat, Bengaluru, India.
C3 National Institute of Mental Health & Neurosciences - India; National
   Institute of Mental Health & Neurosciences - India; National Institute
   of Mental Health & Neurosciences - India; National Institute of Mental
   Health & Neurosciences - India; National Institute of Mental Health &
   Neurosciences - India
RP Gurusamy, J (corresponding author), Natl Inst Mental Hlth & Neuro Sci NIMHANS, Coll Nursing, Bengaluru, India.
EM jothisrinivas.jothi@gmail.com
RI Gurusamy, Jothimani/P-6729-2019
OI Gurusamy, Jothimani/0000-0002-3844-6038
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NR 34
TC 1
Z9 1
U1 2
U2 3
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0920-9964
EI 1573-2509
J9 SCHIZOPHR RES
JI Schizophr. Res.
PD APR
PY 2024
VL 266
BP 75
EP 84
DI 10.1016/j.schres.2024.02.002
EA FEB 2024
PG 10
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA MX3R2
UT WOS:001196900900001
PM 38377870
DA 2025-06-11
ER

PT J
AU Poursalehi, D
   Shahdadian, F
   Hajhashemy, Z
   Lotfi, K
   Moradmand, Z
   Rouhani, P
   Mohammadi, S
   Mokhtari, E
   Saneei, P
AF Poursalehi, Donya
   Shahdadian, Farnaz
   Hajhashemy, Zahra
   Lotfi, Keyhan
   Moradmand, Zahra
   Rouhani, Parisa
   Mohammadi, Sobhan
   Mokhtari, Elahe
   Saneei, Parvane
TI Diet in relation to Metabolic, sleep and psychological health Status
   (DiMetS): protocol for a cross-sectional study
SO BMJ OPEN
LA English
DT Article
DE nutrition & dietetics; diabetes & endocrinology; mental health; sleep
   medicine
ID PHYSICAL-ACTIVITY QUESTIONNAIRE; PERSIAN VERSION; QUALITY INDEX;
   VALIDITY; RELIABILITY; CONSUMPTION; DISORDERS; PATTERNS; OBESITY; RISK
AB Introduction Metabolic disturbances are of major health concerns in the world. In addition to their high prevalence, these disorders have substantial roles in developing other physical and mental diseases. Diet could have a considerable influence on managing the progression of these conditions and their consequent health-related effects. The aim of the 'Diet in relation to Metabolic, sleep and psychological health Status' Project is to explore the association of nutrition with metabolic, sleep and mental health, considering potential mediators including brain-derived neurotrophic factor (BDNF) and adropin.Methods and analysis This cross-sectional study will be conducted on adults (20-65 years) working in schools of Isfahan, Iran. A multistage cluster random sampling method will be used to select participants. Anthropometric, body composition and biochemical values including fasting blood glucose, lipid profile, 25-hydroxy vitamin D, insulin, BDNF, adropin, malondialdehyde, superoxide dismutase, glutathione peroxidase, uric acid, creatinine and C reactive protein will be measured for each participant. National Cholesterol Education Program and Adult Treatment Panel III will be considered to define metabolic syndrome. Diet will be assessed through a validated Food Frequency Questionnaire. Furthermore, sleep status, mental health, quality of life, physical activity and demographic status of individuals will be assessed by validated questionnaires. The collected data will be analysed using appropriate statistical methods.Ethics and dissemination The study protocol was approved by the local Ethics Committee of Isfahan University of Medical Sciences. All participants will provide written informed consent. Dissemination will be through conference presentations and publications in peer-reviewed journals.
C1 [Poursalehi, Donya; Hajhashemy, Zahra; Saneei, Parvane] Isfahan Univ Med Sci, Esfahan, Iran.
   [Shahdadian, Farnaz] Isfahan Univ Med Sci, Dept Clin Nutr, Esfahan, Iran.
   [Lotfi, Keyhan] Univ Tehran Med Sci, Dept Community Nutr, Tehran, Iran.
   [Moradmand, Zahra; Rouhani, Parisa; Mohammadi, Sobhan; Mokhtari, Elahe] Isfahan Univ Med Sci, Dept Community Nutr, Esfahan, Iran.
C3 Isfahan University of Medical Sciences; Isfahan University of Medical
   Sciences; Tehran University of Medical Sciences; Isfahan University of
   Medical Sciences
RP Saneei, P (corresponding author), Isfahan Univ Med Sci, Esfahan, Iran.
EM saneeip@yahoo.com
RI Lotfi, Keyhan/GRO-4022-2022; Shahdadian, Farnaz/ABL-3769-2022; Saneei,
   Parvane/T-5434-2019; Rouhani, Parisa/LKO-0490-2024
OI Mokhtari, Elahe/0000-0003-2368-492X; Saneei, Parvane/0000-0002-4605-7833
FU Isfahan University of Medical Sciences, Isfahan, Iran [399508]
FX The financial support for conception, design, data analysis and
   manuscript drafting comes from Isfahan University of Medical Sciences,
   Isfahan, Iran (no. 399508).
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NR 61
TC 6
Z9 6
U1 1
U2 4
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2044-6055
J9 BMJ OPEN
JI BMJ Open
PD DEC
PY 2023
VL 13
IS 12
AR e076114
DI 10.1136/bmjopen-2023-076114
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA DV8H9
UT WOS:001134943800002
PM 38110391
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Cezaretto, A
   de Barros, CR
   de Almeida-Pititto, B
   Siqueira-Catania, A
   Monfort-Pires, M
   Folchetti, LGD
   Ferreira, SRG
AF Cezaretto, Adriana
   de Barros, Camila Risso
   de Almeida-Pititto, Bianca
   Siqueira-Catania, Antonela
   Monfort-Pires, Milena
   Dias Folchetti, Luciana Gavilan
   Gouvea Ferreira, Sandra Roberta
TI Lifestyle intervention using the psychoeducational approach is
   associated with greater cardiometabolic benefits and retention of
   individuals with worse health status
SO ARCHIVES OF ENDOCRINOLOGY METABOLISM
LA English
DT Article
DE Diabetes prevention; depression; lifestyle; psychoeducation; retention
ID METABOLIC SYNDROME; PHYSICAL-ACTIVITY; WEIGHT-LOSS; PREVENTION;
   SCHIZOPHRENIA; GLUCOSE; OBESITY
AB Objective: This study aimed to compare the effects of two lifestyle intervention programs for type 2 diabetes mellitus (T2DM) prevention-traditional or interdisciplinary psychoeducationbased intervention-in daily habits and cardiometabolic risk factors and investigate the role of the psychoeducational approach for the retention of individuals in the program. Subjects and methods: Between 2008 and 2010, in a public health service, 183 pre-diabetic individuals were allocated to two 18-month interventions involving diet and physical activity. Physical activity, diet, quality of life (QOL) and depression and biochemical measurements were obtained. Linear mixed-effect models were used to assess the effect of the interventions. A student t test was used to compare dropouts versus non-dropouts. Results: Improvements in energy intake and physical activity were greater in the interdisciplinary than the traditional intervention. A decrease in fat mass and blood pressure was more pronounced with interdisciplinary intervention. Dropouts from the traditional intervention only had higher BMI and lower fiber intake and QOL than non-dropouts. Conclusion: The interdisciplinary psychoeducation-based intervention revealed useful for reducing cardiometabolic risk and retaining individuals with worse health profiles. This approach represents a feasible strategy for motivating high-risk individuals to adopt a long-term healthy lifestyle.
C1 [Cezaretto, Adriana; de Barros, Camila Risso; de Almeida-Pititto, Bianca; Siqueira-Catania, Antonela; Monfort-Pires, Milena; Dias Folchetti, Luciana Gavilan; Gouvea Ferreira, Sandra Roberta] Univ Sao Paulo, Dept Epidemiol, Fac Saude Publ, Av Dr Arnaldo 715, BR-01246904 Sao Paulo, SP, Brazil.
C3 Universidade de Sao Paulo
RP Ferreira, SRG (corresponding author), Univ Sao Paulo, Dept Epidemiol, Fac Saude Publ, Av Dr Arnaldo 715, BR-01246904 Sao Paulo, SP, Brazil.
EM sandrafv@usp.br
RI Ferreira, Sandra/B-9840-2012; Cezaretto, Adriana/A-4180-2015; de Almeida
   Pititto, Bianca/N-2075-2018
OI Ferreira, Sandra/0000-0002-7015-7391; de Almeida Pititto,
   Bianca/0000-0002-5907-5459; Monfort-Pires, Milena/0000-0002-1652-8083
FU Sao Paulo Research Foundation (Fapesp) [11/06376-7]; Fundacao de Amparo
   a Pesquisa do Estado de Sao Paulo (FAPESP) [11/06376-7] Funding Source:
   FAPESP
FX funding was provided by the Sao Paulo Research Foundation (Fapesp
   process number: 11/06376-7) for a student (Adriana Cezaretto) and for a
   researcher (Sandra Roberta G. Ferreira; process number: 07/55120-0).
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NR 37
TC 3
Z9 3
U1 1
U2 12
PU SBEM-SOC BRASIL ENDOCRINOLOGIA & METABOLOGIA
PI RIO DE JANEIRO, RJ
PA RUA HUMAITA, 85 CJ 501, RIO DE JANEIRO, RJ, 22261-000, BRAZIL
SN 2359-3997
EI 2359-4292
J9 ARCH ENDOCRIN METAB
JI Arch. Endocrinol. Metab.
PD FEB
PY 2017
VL 61
IS 1
BP 36
EP 44
DI 10.1590/2359-3997000000185
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA EN1XW
UT WOS:000395804800007
PM 28273202
OA gold, Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Govindan, R
   Rangaswamy, T
   John, S
   Kandasamy, S
AF Govindan, Ramanujam
   Rangaswamy, Thara
   John, Sujit
   Kandasamy, Sunitha
TI Methodology for Development of a Community Level Intervention Module for
   Physical Illness in Persons with Mental Illness (CLIPMI)
SO INDIAN JOURNAL OF PSYCHOLOGICAL MEDICINE
LA English
DT Article
DE Community engagement; community mental health; community psychiatry;
   social intervention
ID METABOLIC SYNDROME; ANXIETY DISORDERS; PRIMARY-CARE; PREVALENCE; IMPACT;
   SCHIZOPHRENIA; MANAS; GOA
AB Background and Objectives:
   Medical illnesses seen in persons with psychiatric disorders are important but often ignored causes of increased morbidity and mortality. Hence, a community level intervention program addressing the issue is proposed.
   Materials and Methods:
   Patients with severe mental illnesses will be identified by a door-to-door survey and assessed for comorbid physical illnesses like anemia, hypertension, diabetes, and so on. They will then be randomized into two groups. The treatment as usual (TAU) group will not receive intervention from the trained community level workers, while the Intervention group will receive it.
   Results:
   The two groups will be compared for the prevalence and severity of comorbid physical illnesses. The expected outcome is compared to the TAU group, the intervention group will have a greater reduction in the morbidity due to physical illnesses and improved mental health.
   Conclusion:
   If successful, the module can be incorporated into the community level mental health delivery system of the District Mental Health Program (DMHP).
C1 [Govindan, Ramanujam; Kandasamy, Sunitha] Tirunelveli Med Coll, B 69,17th Cross St, Tirunelveli, Tamil Nadu, India.
   [Rangaswamy, Thara; John, Sujit] Schizophrenia Res Fdn, Chennai, Tamil Nadu, India.
RP Govindan, R (corresponding author), Tirunelveli Med Coll, B 69,17th Cross St, Tirunelveli, Tamil Nadu, India.
EM ramsych2@gmail.com
RI Rangaswamy, Thara/JXK-9468-2024
OI Rangaswamy, Thara/0000-0001-6813-066X; John, Sujit/0000-0001-7157-3533
FU 'Capacity Building Task Force for Mental Health Research in India' -
   Indian Council of Medical Research [5/4-4/151/M/2017/NCD-1]; training
   program `Cross Fertilized Research Training for New Investigators in
   India and Egypt' - FIC, NIH [D43 TW009114]
FX This protocol paper describes the methodology of a research project
   funded under 'Capacity Building Task Force for Mental Health Research in
   India' funded by the Indian Council of Medical Research vide file number
   5/4-4/151/M/2017/NCD-1. International mentors were funded by the
   training program `Cross Fertilized Research Training for New
   Investigators in India and Egypt' funded by FIC, NIH (No. D43 TW009114).
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NR 20
TC 2
Z9 2
U1 1
U2 3
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0253-7176
EI 0975-1564
J9 INDIAN J PSYCHOL MED
JI Indian J. Psychol. Med.
PD DEC
PY 2020
VL 42
IS 6_SUPPL
SU 6_
BP S94
EP S98
DI 10.1177/0253717620973381
PG 5
WC Psychiatry; Psychology
WE Emerging Sources Citation Index (ESCI)
SC Psychiatry; Psychology
GA QA9XI
UT WOS:000613797400016
PM 33487810
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Kure, C
AF Kure, Christine
TI Cognitive health
SO JOURNAL OF COMPLEMENTARY MEDICINE
LA English
DT Article
ID DOSE-DEPENDENT CHANGES; EXTRACT EGB 761(R); ALPHA-LIPOIC ACID;
   BACOPA-MONNIERA; GINKGO-BILOBA; DOUBLE-BLIND; ALZHEIMERS-DISEASE;
   STANDARDIZED EXTRACT; OXIDATIVE STRESS; CENTRAL OBESITY
AB Oxidative stress, inflammation and free-radical damage to mitochondria have been associated with neurodegenerative diseases such as Alzheimer's and Parkinson's
   Various risk factors have been associated with age-related cognitive decline, including hypertension, obesity, diabetes, metabolic syndrome, history of anxiety/depression, elevated homocysteine levels, inflammation, alcohol intake, smoking and diet
   Epidemiological, clinical and preclinical studies have shown that some traditional herbal, mind-body and nutraceutical treatments are effective in preventing age-related cognitive decline
   Limited research has been conducted on the benefits of such treatments on neurodegenerative disorders such as Parkinson's disease
C1 Swinburne Univ Technol, BSI, NICM Collaborat Ctr Neurocognit, Hawthorn, Vic 3122, Australia.
C3 Swinburne University of Technology
RP Kure, C (corresponding author), Swinburne Univ Technol, BSI, NICM Collaborat Ctr Neurocognit, Hawthorn, Vic 3122, Australia.
OI Kure, Christina/0000-0001-8328-0084
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NR 75
TC 0
Z9 0
U1 0
U2 9
PU AUSTRALIAN PHARMACEUTICAL PUBLISHING CO LTD
PI HAWTHORN
PA 40 BURWOOD ROAD, HAWTHORN, VIC 3122, AUSTRALIA
SN 1446-8263
J9 J COMPLEMENT MED
JI J. Complement. Med.
PD SEP-OCT
PY 2009
VL 8
IS 5
BP 12
EP +
PG 6
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA 496HO
UT WOS:000269961100015
DA 2025-06-11
ER

PT J
AU Busnatu, SS
   Serbanoiu, LI
   Lacraru, AE
   Andrei, CL
   Jercalau, CE
   Stoian, M
   Stoian, A
AF Busnatu, Stefan Sebastian
   Serbanoiu, Liviu Ionut
   Lacraru, Andreea Elena
   Andrei, Catalina Liliana
   Jercalau, Cosmina Elena
   Stoian, Marilena
   Stoian, Anca
TI Effects of Exercise in Improving Cardiometabolic Risk Factors in
   Overweight Children: A Systematic Review and Meta-Analysis
SO HEALTHCARE
LA English
DT Review
DE physical stress; cardiometabolic; risk factors; long term intervention
ID CORONARY-ARTERY-DISEASE; BODY-MASS INDEX; QUALITY-OF-LIFE; CHILDHOOD
   OBESITY; ADIPOSE-TISSUE; WEIGHT-LOSS; MENTAL-HEALTH; FAT MASS;
   INTERVENTIONS; ADOLESCENTS
AB This meta-analysis aims to evaluate the effects of exercise in improving cardiometabolic risk factors in overweight children and adolescents until the adolescent age, which is 18 years. A systemic search was conducted using the electronic databases PubMed/Medline, Cochrane Library, and Google Scholar, from inception to 29 June 2021. All statistical analyses were conducted in Review Manager 5.4.1. All studies meeting the inclusion criteria were selected. A random-effect model was used to pool the studies, and the results are reported in the odds ratio (OR) and corresponding 95% Confidence interval (CI). Twelve randomized control trials were selected for meta-analysis. Significant results were obtained for BMI in children after the interventions (0.38 95% CI 0.14, 0.62; p = 0.002; I-2 = 65%). LDL level was also found significantly reduced (0.41 95% CI 0.01, 0.82; p = 0.05; I-2 = 83%). Other factors such as HDL level, blood pressure, blood glucose level, body weight, and waist circumference were also analyzed. We found that exercise interventions significantly improved several cardiometabolic risk factors such as BMI, LDL level, BP, and blood glucose level. However, no significant effect on HDL concentration, waist circumference, and body weight were found. Long-term interventions are needed to attain improvement in all cardiometabolic risk factors.
C1 [Busnatu, Stefan Sebastian; Serbanoiu, Liviu Ionut; Lacraru, Andreea Elena; Andrei, Catalina Liliana; Jercalau, Cosmina Elena; Stoian, Marilena; Stoian, Anca] Univ Med & Pharm Carol Davila, Emergency Hosp Bagdasar Arseni, Dept Cardiol, Bucharest 050474, Romania.
   [Stoian, Anca] Carol Davila Univ Med & Pharm, Dept Diabet Nutr & Metab Dis, Bucharest 020021, Romania.
C3 Carol Davila University of Medicine & Pharmacy; Carol Davila University
   of Medicine & Pharmacy
RP Serbanoiu, LI (corresponding author), Univ Med & Pharm Carol Davila, Emergency Hosp Bagdasar Arseni, Dept Cardiol, Bucharest 050474, Romania.
EM stefan.busnatu@umfcd.ro; liviu-ionut.serbanoiu@drd.umfcd.ro;
   andreea.lacraru@umfcd.ro; catalina.andrei@umfcd.ro;
   cosmina-elena.jercalau@rez.umfcd.ro; marinela.stoian@umfcd.ro;
   anca.stoian@umfcd.ro
RI Busnatu, Stefan/K-7025-2019; Andrei, Catalina/KHU-8658-2024; Serbanoiu,
   Liviu Ionut/GQA-8087-2022; Pantea Stoian, Anca/H-5799-2017
OI Serbanoiu, Liviu Ionut/0000-0001-5081-2478; Jercalau,
   Cosmina/0000-0003-3290-2730; Busnatu, Stefan/0000-0002-4678-9655; Pantea
   Stoian, Anca/0000-0003-0555-526X
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NR 83
TC 13
Z9 13
U1 3
U2 15
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2227-9032
J9 HEALTHCARE-BASEL
JI Healthcare
PD JAN
PY 2022
VL 10
IS 1
AR 82
DI 10.3390/healthcare10010082
PG 17
WC Health Care Sciences & Services; Health Policy & Services
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services
GA YN9XZ
UT WOS:000747604800001
PM 35052246
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Roohafza, H
   Sadeghi, M
   Talaei, M
   Pourmoghaddas, Z
   Sarrafzadegan, N
AF Roohafza, Hamidreza
   Sadeghi, Masoumeh
   Talaei, Mohammad
   Pourmoghaddas, Zahra
   Sarrafzadegan, Nizal
TI Psychological Status and Quality of Life in relation to the Metabolic
   Syndrome: Isfahan Cohort Study
SO INTERNATIONAL JOURNAL OF ENDOCRINOLOGY
LA English
DT Article
ID DEPRESSIVE SYMPTOMS; YOUNG-ADULTS; HEALTH; WOMEN; POPULATION;
   PREVALENCE; ANXIETY; RISK
AB Objective. Current study was designed to investigate the association of metabolic syndrome (MetS) with depression, anxiety, psychological distress, and quality of life (QoL). Design. Two hundred and fifteen contributors with MetS and 253 participants without MetS were randomly selected from 2151 participants of Isfahan Cohort Study who were residents of Isfahan city. Measurements consisted of fasting blood samples, anthropometrics, and self-reported data of 12-item General Health Questionnaire, Hospital Anxiety and Depression Scale, and European Quality of Life-5 Dimension. Binary logistic regression analysis was used to find the association between MetS and four psychological factors. Results. Participants mean age was 56.3 +/- 9.8 years. Male/female ratio was 0.86 (217/251). Mean score of depression (P = 0.003), anxiety (P = 0.018), distress (P = 0.047), and QoL (P <= 0.001) was significantly higher in MetS group. There were significant increasing relationships between depression (OR 1.10, 95% CI 1.03-1.22), anxiety (OR 1.03, 95% CI 1.05-1.11), and QoL (OR 1.13, 95% CI 1.05-1.23) and MetS when associations were adjusted for other risk factors, but it was not the case for distress (OR 1.03, 95% CI 0.99-1.08). Conclusion. It might be better to consider MetS as a combination of biological and psychological risk factors. Thus, a person with metabolic disease should be recognized as a patient with these factors and be screened for all of them.
C1 [Sadeghi, Masoumeh] Isfahan Univ Med Sci, Cardiac Rehabil Res Ctr, Isfahan Cardiovasc Res Inst, WHO Collaborating Ctr, Esfahan, Iran.
   [Roohafza, Hamidreza; Talaei, Mohammad; Sarrafzadegan, Nizal] Isfahan Univ Med Sci, Cardiovasc Res Ctr, Isfahan Cardiovasc Res Inst, WHO Collaborating Ctr, Esfahan 814651148, Iran.
   [Pourmoghaddas, Zahra] Isfahan Univ Med Sci, Child Hlth Promot Res Ctr, Sch Med, Esfahan 814651148, Iran.
C3 Isfahan University of Medical Sciences; World Health Organization;
   Isfahan University of Medical Sciences; World Health Organization;
   Isfahan University of Medical Sciences
RP Sadeghi, M (corresponding author), Isfahan Univ Med Sci, Cardiac Rehabil Res Ctr, Isfahan Cardiovasc Res Inst, WHO Collaborating Ctr, POB 81465-1148, Esfahan, Iran.
EM m_sadeghi@crc.mui.ac.ir
RI pourmoghaddas, zahra/B-8213-2011; Sadeghi, Masoumeh/W-2291-2017;
   Sarrafzadegan, Nizal/V-5826-2017; Talaei, Mohammad/A-1819-2009
OI Sarrafzadegan, Nizal/0000-0002-8352-0540; Talaei,
   Mohammad/0000-0002-6901-3665; Sadeghi Mahonak,
   Masoumeh/0000-0001-7179-5558; Roohafza, Hamidreza/0000-0003-3582-0431;
   Pourmoghaddas, Zahra/0000-0002-5424-3919
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NR 27
TC 34
Z9 36
U1 0
U2 3
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1687-8337
EI 1687-8345
J9 INT J ENDOCRINOL
JI Int. J. Endocrinol.
PY 2012
VL 2012
AR 380902
DI 10.1155/2012/380902
PG 5
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism
GA 955IR
UT WOS:000305011600001
PM 22675350
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Ren, J
   Kelley, RO
AF Ren, Jun
   Kelley, Robert O.
TI Cardiac Health in Women With Metabolic Syndrome: Clinical Aspects and
   Pathophysiology
SO OBESITY
LA English
DT Review
ID NITRIC-OXIDE SYNTHASE; POSTMENOPAUSAL HORMONE-THERAPY; ISOLATED
   VENTRICULAR MYOCYTES; ESTROGEN REPLACEMENT THERAPY;
   AMERICAN-HEART-ASSOCIATION; TYPE-2 DIABETES-MELLITUS;
   CARDIOVASCULAR-DISEASE; CONTRACTILE FUNCTION; GLUCOSE-METABOLISM;
   GENDER-DIFFERENCES
AB Although the classical cardiovascular risk factors (e. g., smoking and hypertension) are becoming more effectively managed, a continuous increase of the so-called "cardiometabolic risk" is noted. Starting from this century, the nomenclature "metabolic syndrome" has become more popular to identify a cluster of disorders including obesity, dyslipidemia, hypertension, and insulin resistance. It is a primary risk factor for diabetes and cardiovascular disease in both genders. Interestingly, the metabolic diseases display a distinct gender disparity with an apparent "female advantage" in the premenopausal women compared with age-matched men. However, women usually lose such "sex protection" following menopause or affliction of metabolic syndrome especially insulin resistance. A controversy exists in the medical literature concerning whether metabolic syndrome is a real syndrome or simply a cluster of risk factors. Several scenarios are speculated to contribute to the gender dimorphism in the cardiovascular sequelae in patients with metabolic syndrome including sex hormones, intrinsic organ function, and the risk factor profile (e. g., hypertension, dyslipidemia, obesity, sedentary lifestyle, and atherogenic diet). With the alarming rise of obesity prevalence, heart problems in metabolic syndrome continue to rise with a distinct gender dimorphism. Although female hearts seem to better tolerate the stress insults compared with the male counterparts, the female sex hormones such as estrogen can interact with certain risk factors to precipitate myopathic changes in the hearts. This synthetic review of recent literature suggests a role of gender disparity in myopathic factors and risk attributable to each metabolic component in the different prevalence of metabolic syndrome.
C1 [Ren, Jun; Kelley, Robert O.] Univ Wyoming, Coll Hlth Sci, Laramie, WY 82071 USA.
C3 University of Wyoming
RP Ren, J (corresponding author), Univ Wyoming, Coll Hlth Sci, Laramie, WY 82071 USA.
EM jren@uwyo.edu
RI Ren, Jun/ACG-5366-2022
OI Ren, Jun/0000-0002-0275-0783
FU NIH [P20 RR016474]; National Center for Research Resources (NCRR)
FX This publication was made possible by an NIH grant # P20 RR016474 from
   National Center for Research Resources (NCRR). We apologize to those
   authors whose important study cannot be covered due to space
   constraints.
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NR 116
TC 83
Z9 91
U1 1
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1930-7381
EI 1930-739X
J9 OBESITY
JI Obesity
PD JUN
PY 2009
VL 17
IS 6
BP 1114
EP 1123
DI 10.1038/oby.2009.8
PG 10
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 450EG
UT WOS:000266383200004
PM 19214173
OA Bronze
DA 2025-06-11
ER

PT J
AU Heppner, PS
   Crawford, EF
   Haji, UA
   Afari, N
   Hauger, RL
   Dashevsky, BA
   Horn, PS
   Nunnink, SE
   Baker, DG
AF Heppner, Pia S.
   Crawford, Eric F.
   Haji, Uzair A.
   Afari, Niloofar
   Hauger, Richard L.
   Dashevsky, Boris A.
   Horn, Paul S.
   Nunnink, Sarah E.
   Baker, Dewleen G.
TI The association of posttraumatic stress disorder and metabolic syndrome:
   a study of increased health risk in veterans
SO BMC MEDICINE
LA English
DT Article
ID PITUITARY-ADRENAL AXIS; 3RD NATIONAL-HEALTH; ALLOSTATIC LOAD;
   DIABETES-MELLITUS; PLASMA; DIAGNOSIS; ILLNESS; NEUROENDOCRINE;
   PREVALENCE; DEPRESSION
AB Background: There is accumulating evidence for a link between trauma exposure, posttraumatic stress disorder (PTSD) and diminished health status. To assess PTSD-related biological burden, we measured biological factors that comprise metabolic syndrome, an important established predictor of morbidity and mortality, as a correlate of long-term health risk in PTSD.
   Methods: We analyzed clinical data from 253 male and female veterans, corresponding to five factors linked to metabolic syndrome (systolic and diastolic blood pressure, waist-to-hip ratio and fasting measures of high-density lipoprotein (HDL) cholesterol, serum triglycerides and plasma glucose concentration). Clinical cut-offs were defined for each biological parameter based on recommendations from the World Health Organization and the National Cholesterol Education Program. Controlling for relevant variables including sociodemographic variables, alcohol/substance/nicotine use and depression, we examined the impact of PTSD on metabolic syndrome using a logistic regression model.
   Results: Two-fifths (40%) of the sample met criteria for metabolic syndrome. Of those with PTSD (n = 139), 43% met criteria for metabolic syndrome. The model predicted metabolic syndrome well (- 2 log likelihood = 316.650, chi-squared = 23.731, p = 0.005). Veterans with higher severity of PTSD were more likely to meet diagnostic criteria for metabolic syndrome (Wald = 4.76, p = 0.03).
   Conclusion: These findings provide preliminary evidence linking higher severity of PTSD with risk factors for diminished health and increased morbidity, as represented by metabolic syndrome.
C1 [Heppner, Pia S.; Haji, Uzair A.; Afari, Niloofar; Hauger, Richard L.; Nunnink, Sarah E.; Baker, Dewleen G.] Vet Affairs San Diego Hlth Care Syst, Res Serv, San Diego, CA 92161 USA.
   [Heppner, Pia S.; Afari, Niloofar; Hauger, Richard L.; Baker, Dewleen G.] Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA.
   [Crawford, Eric F.] Durham Vet Affairs Med Ctr, Durham, NC 27705 USA.
   [Dashevsky, Boris A.; Horn, Paul S.] Cincinnati Vet Affairs Med Ctr, Psychiat Serv, Cincinnati, OH 45220 USA.
   [Horn, Paul S.] Univ Cincinnati, Dept Math Sci, Cincinnati, OH 45221 USA.
C3 US Department of Veterans Affairs; Veterans Health Administration (VHA);
   VA San Diego Healthcare System; University of California System;
   University of California San Diego; US Department of Veterans Affairs;
   Veterans Health Administration (VHA); Durham VA Medical Center; US
   Department of Veterans Affairs; Veterans Health Administration (VHA);
   Cincinnati VA Medical Center; University System of Ohio; University of
   Cincinnati
RP Heppner, PS (corresponding author), Vet Affairs San Diego Hlth Care Syst, Res Serv, MC 151,Jolla Village Dr, San Diego, CA 92161 USA.
EM pheppner@ucsd.edu; Eric.Crawford@va.gov; uzair.haji2@va.gov;
   nafari@ucsd.edu; rhauger@ucsd.edu; boris_dashevsky@hotmail.com;
   paul.horn@uc.edu; sarah.nunnink@va.gov; dgbaker@ucsd.edu
RI Horn, Paul/LPA-6457-2024; Baker, Dewleen/O-4957-2019
FU VACO Research funds; NIH [R01AR51524]; VA Center of Excellence for
   Stress and Mental Health
FX DGB and RLH are supported by VACO Research funds (VA Merit Review,
   VA-DOD, MIRECC, HSR&D, and the Office of Environmental Hazards). This
   work is supported in part by these funds. NA is supported in part by NIH
   R01AR51524. PSH (1), NA, DGB, RLH, and SEN are also supported by the VA
   Center of Excellence for Stress and Mental Health. We thank the
   clinicians at the Veterans Affairs of Cincinnati who participated in the
   collection of data and Laura Harder who provided assistance with
   manuscript formatting.
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NR 55
TC 120
Z9 136
U1 0
U2 12
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1741-7015
J9 BMC MED
JI BMC Med.
PD JAN 9
PY 2009
VL 7
AR 1
DI 10.1186/1741-7015-7-1
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA 419BX
UT WOS:000264195200001
PM 19134183
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Hashizume, K
   Suzuki, S
   Hara, M
   Komatsu, A
   Yamashita, K
AF Hashizume, Kiyoshi
   Suzuki, Satoru
   Hara, Masahiro
   Komatsu, Ai
   Yamashita, Koh
TI Metabolic syndrome and age-related dementia: Endocrinological aspects of
   adaptation to aging
SO MECHANISMS OF AGEING AND DEVELOPMENT
LA English
DT Review
DE metabolic syndrome; cognition disorder; thyroid hormone; growth hormone
ID SERUM-CHOLESTEROL CONCENTRATION; DOSE SIMVASTATIN THERAPY; LARGE-SCALE
   COHORT; THYROID-HORMONE; PREVENTION COHORT; JAPANESE PATIENTS; CORONARY
   EVENTS; DISEASE; HYPERCHOLESTEROLEMIA; MORTALITY
AB Metabolic syndrome is one of the determinants of lifespan in Japan. In order to prevent the acute vascular events, intervention is recommended. However, management of patients with this syndrome increased the number of patients with cognition decline and depressive state.
   Endocrinological studies with human and experimental animals showed that there is a negative relationship between progression of metabolic syndrome and occurrence of mental disorders. In this review, we summarize our clinical and experimental data, and discuss on the mechanism of the metabolic syndrome prevention of progression of age-related mental disorder. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
EM hshzmk@hsp.md.shinshu-u.ac.jp
RI Suzuki, Satoru/G-3584-2011
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NR 25
TC 4
Z9 4
U1 0
U2 2
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0047-6374
EI 1872-6216
J9 MECH AGEING DEV
JI Mech. Ageing Dev.
PD JUN
PY 2006
VL 127
IS 6
BP 507
EP 510
DI 10.1016/j.mad.2006.01.026
PG 4
WC Cell Biology; Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Geriatrics & Gerontology
GA 047YZ
UT WOS:000237915900002
PM 16574195
DA 2025-06-11
ER

PT J
AU McDermott, KA
   Rao, MR
   Nagarathna, R
   Murphy, EJ
   Burke, A
   Nagendra, RH
   Hecht, FM
AF McDermott, Kelly A.
   Rao, Mohan Raghavendra
   Nagarathna, Raghuram
   Murphy, Elizabeth J.
   Burke, Adam
   Nagendra, Ramarao Hongasandra
   Hecht, Frederick M.
TI A yoga intervention for type 2 diabetes risk reduction: a pilot
   randomized controlled trial
SO BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Article
DE Yoga; Prediabetes; Type 2 diabetes; India; Randomized controlled pilot
ID INSULIN-RESISTANCE-SYNDROME; IMPAIRED FASTING GLUCOSE; METABOLIC
   SYNDROME; PHYSICAL-ACTIVITY; LIFE-STYLE; EXERCISE; PREVENTION; MELLITUS;
   PREVALENCE; BENEFITS
AB Background: Type 2 diabetes is a major health problem in many countries including India. Yoga may be an effective type 2 diabetes prevention strategy in India, particularly given its cultural familiarity.
   Methods: This was a parallel, randomized controlled pilot study to collect feasibility and preliminary efficacy data on yoga for diabetes risk factors among people at high risk of diabetes. Primary outcomes included: changes in BMI, waist circumference, fasting blood glucose, postprandial blood glucose, insulin, insulin resistance, blood pressure, and cholesterol. We also looked at measures of psychological well-being including changes in depression, anxiety, positive and negative affect and perceived stress. Forty-one participants with elevated fasting blood glucose in Bangalore, India were randomized to either yoga (n = 21) or a walking control (n = 20). Participants were asked to either attend yoga classes or complete monitored walking 3-6 days per week for eight weeks. Randomization and allocation was performed using computer-generated random numbers and group assignments delivered in sealed, opaque envelopes generated by off-site study staff. Data were analyzed based on intention to treat.
   Results: This study was feasible in terms of recruitment, retention and adherence. In addition, yoga participants had significantly greater reductions in weight, waist circumference and BMI versus control (weight -0.8 +/- 2.1 vs. 1.4 +/- 3.6, p = 0.02; waist circumference -4.2 +/- 4.8 vs. 0.7 +/- 4.2, p < 0.01; BMI -0.2 +/- 0.8 vs. 0.6 +/- 1.6, p = 0.05). There were no between group differences in fasting blood glucose, postprandial blood glucose, insulin resistance or any other factors related to diabetes risk or psychological well-being. There were significant reductions in systolic and diastolic blood pressure, total cholesterol, anxiety, depression, negative affect and perceived stress in both the yoga intervention and walking control over the course of the study.
   Conclusion: Among Indians with elevated fasting blood glucose, we found that participation in an 8-week yoga intervention was feasible and resulted in greater weight loss and reduction in waist circumference when compared to a walking control. Yoga offers a promising lifestyle intervention for decreasing weight-related type 2 diabetes risk factors and potentially increasing psychological well-being.
C1 [McDermott, Kelly A.; Hecht, Frederick M.] Univ Calif San Francisco, Osher Ctr Integrat Med, San Francisco, CA 94115 USA.
   [Rao, Mohan Raghavendra; Nagarathna, Raghuram; Nagendra, Ramarao Hongasandra] Swami Vivekananda Yoga Anusandhana Samsthana, Bangalore, Karnataka, India.
   [Murphy, Elizabeth J.] Univ Calif San Francisco, Dept Med, Div Endocrinol & Metab, San Francisco, CA 94115 USA.
   [Burke, Adam] San Francisco State Univ, Inst Holist Hlth Studies, San Francisco, CA 94132 USA.
C3 University of California System; University of California San Francisco;
   University of California System; University of California San Francisco;
   California State University System; San Francisco State University
RP McDermott, KA (corresponding author), Univ Calif San Francisco, Osher Ctr Integrat Med, 1545 Div St, San Francisco, CA 94115 USA.
EM mcdermottk@ocim.ucsf.edu
RI Nagaratna, R/GQI-3110-2022; Rao, Raghavendra/KJM-4435-2024
OI Hecht, Frederick/0000-0002-5782-1171; Raghuram,
   Nagarathna/0000-0002-1666-1407
FU US National Institutes of Health [NCCAM R21 AT01942]; National Center
   for Complementary and Integrative Health [T32AT003997, K24AT007827]
   Funding Source: NIH RePORTER
FX This study was supported with a grant from the US National Institutes of
   Health, NCCAM R21 AT01942.
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NR 39
TC 64
Z9 71
U1 1
U2 31
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1472-6882
J9 BMC COMPLEM ALTERN M
JI BMC Complement. Altern. Med.
PD JUL 1
PY 2014
VL 14
AR 212
DI 10.1186/1472-6882-14-212
PG 14
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA AL1LZ
UT WOS:000338888200001
PM 24980650
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Degirmenci, DM
   Ugurlu, YK
   Alemdar, DK
AF Degirmenci, Duygu Mataraci
   Ugurlu, Yasemin Kalkan
   Alemdar, Dilek Kucuk
TI The relationship between coronavirus anxiety level and emotional eating
   in individuals with metabolic syndrome
SO PSYCHOLOGY HEALTH & MEDICINE
LA English
DT Article
DE Anxiety; COVID-19; eating; metabolic syndrome
ID COVID-19; DEPRESSION
AB This study used a descriptive, cross-sectional and relational screening model. The full sampling method was used in this study. The study was completed with 105 individuals with MetS attending the outpatient nutrition clinic and 109 non-MetS individuals without MetS diagnosis, who also attended the outpatient nutrition clinic. The data included anthropometric measurements, biochemical findings, blood pressure, a survey form, the Coronavirus Anxiety Scale (CAS), and the Emotional Eating Scale (EES). The coronavirus anxiety scale scores of individuals with MetS were found to be statistically significantly higher than those of the non-MetS group (p <0.05). The difference in the emotional eating scale scores between the MetS and non-MetS groups was not significant (p <0.05). Individuals with MetS had higher coronavirus anxiety levels than those without MetS; however, there was no difference between participants with and without MetS in terms of emotional eating behavior.
C1 [Degirmenci, Duygu Mataraci] Ordu Univ, Fac Hlth Sci, Dept Nutr & Dietet, Ordu, Turkey.
   [Ugurlu, Yasemin Kalkan; Alemdar, Dilek Kucuk] Ordu Univ, Fac Hlth Sci, Dept Nursing, Ordu, Turkey.
C3 Ordu University; Ordu University
RP Alemdar, DK (corresponding author), Ordu Univ, Fac Hlth Sci, TR-52200 Ordu, Turkey.
EM dilekkucuk@atauni.edu.tr
RI mataracı değirmenci, duygu/LTG-0468-2024; Kalkan Uğurlu,
   Yasemin/GLS-8636-2022
OI Kucuk Alemdar, Dilek/0000-0002-7275-0666; Kalkan ugurlu,
   Yasemin/0000-0003-0096-5593; MATARACI DEGIRMENCI,
   Duygu/0000-0003-2136-1545
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NR 20
TC 0
Z9 0
U1 2
U2 4
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 1354-8506
EI 1465-3966
J9 PSYCHOL HEALTH MED
JI Psychol. Health Med.
PD NOV 26
PY 2023
VL 28
IS 10
BP 3156
EP 3162
DI 10.1080/13548506.2022.2080841
EA MAY 2022
PG 7
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA DU0Q9
UT WOS:000799837800001
PM 35608222
DA 2025-06-11
ER

PT J
AU Schwartz, T
   Bedynerman, K
AF Schwartz, T.
   Bedynerman, K.
TI UTILIZING PHARMACODYNAMIC PROPERTIES OF SECOND-GENERATION ANTI
   PSYCHOTICS TO GUIDE TREATMENT
SO DRUGS OF TODAY
LA English
DT Review
DE Antipsychotics; Atypical antipsychotics; Pharmacokinetics;
   Pharmacodynamics; Dosing strategies
ID SEROTONIN REUPTAKE INHIBITORS; DOUBLE-BLIND; METABOLIC SYNDROME;
   ANTIDEPRESSANT; RISPERIDONE; EFFICACY; ANTIPSYCHOTICS; ZIPRASIDONE;
   MONOTHERAPY; OLANZAPINE
AB Second-generation antipsychotics (SGAs) are used for the treatment of multiple psychiatric disorders including schizophrenia, bipolar depression, bipolar mania, autism and major depressive disorder. Additionally, their off-label use has been expanding to include other disorders as well, including post-traumatic stress disorder, obsessive compulsive disorder, generalized anxiety disorder, eating disorders and personality disorders. All SGAs share common properties; however, each individual SGA has a unique pharmacodynamic profile that may be utilized to guide and individualize treatment.
C1 [Schwartz, T.; Bedynerman, K.] SUNY Upstate Med Univ, Dept Psychiat, Syracuse, NY 13210 USA.
C3 State University of New York (SUNY) System; State University of New York
   (SUNY) Upstate Medical Center
RP Schwartz, T (corresponding author), SUNY Upstate Med Univ, Dept Psychiat, 730 E Adams St, Syracuse, NY 13210 USA.
EM SchwartT@upstate.edu
CR [Anonymous], 2011, CYMB DUL HYDR
   [Anonymous], 2011, SAPHR AS MAL
   [Anonymous], 2011, ZYPR OL
   [Anonymous], 2010, GEOD ZIPR
   [Anonymous], 2011, LAT LUR HYDR
   [Anonymous], 2011, STRATT AT HYDR
   [Anonymous], SER QUET FUM
   [Anonymous], 2011, RISP RISP
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   [Anonymous], 2012, ABL AR
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NR 45
TC 3
Z9 3
U1 0
U2 7
PU PROUS SCIENCE, SAU-THOMSON REUTERS
PI BARCELONA
PA 398 PROVENCA, 08025 BARCELONA, SPAIN
SN 1699-3993
EI 1699-4019
J9 DRUG TODAY
JI Drugs Today
PD APR
PY 2012
VL 48
IS 4
BP 283
EP 292
DI 10.1358/dot.2012.48.4.1745225
PG 10
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 959GY
UT WOS:000305302100004
PM 22536570
DA 2025-06-11
ER

PT J
AU Kim, CJ
   Schlenk, EA
   Kang, SW
   Park, JB
AF Kim, Chun-Ja
   Schlenk, Elizabeth A.
   Kang, Se-Won
   Park, Jae-Bum
TI Effects of an internet-based lifestyle intervention on cardio-metabolic
   risks and stress in Korean workers with metabolic syndrome: A controlled
   trial
SO PATIENT EDUCATION AND COUNSELING
LA English
DT Article
DE Metabolic syndrome X; Cardio-metabolic risk; Stress; Physical activity;
   Behavioral research
ID OVERWEIGHT WORKING POPULATION; CARDIOVASCULAR-DISEASE RISK; WEB-BASED
   INTERVENTIONS; BEHAVIOR-CHANGE; HEALTH; PREVALENCE; WORKPLACE; PROGRAM;
   MANAGEMENT; REDUCTION
AB Objective: This study examined the effects of an Internet-based Best Exerciser Super Trainer (BEST) program on cardio-metabolic risks and stress among workers with metabolic syndrome.
   Methods: This study utilized a non-randomized, pretest, and posttest, controlled design with a convenience sample of 48 Korean male workers. The workers in the BEST group participated in a 16-week Internet-based program: 150 min of regular physical activity per week, 200- to 300-kcal reduced daily diet for weight control, one-on-one counseling, and mobile phone text messages. Workers in the Education group received text messages and an educational booklet.
   Results: There were significant group by time interactions in cardio-metabolic risks: body weight (p = .022), visceral fat mass (p = .033), and waist circumference (p = .037). There was no group by time interaction in stress (p >. 05); however, the BEST group showed a significantly greater reduction in health-related stress than those in the Education group (p = .025).
   Conclusion: This study yielded evidence of the beneficial impact of the Internet-based BEST program for workers with metabolic syndrome on selected cardio-metabolic risks and health-related stress. Practice implications: Internet-based one-on-one counseling and mobile phone text messages can assist individuals with targeted lifestyle modifications for metabolic syndrome. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
C1 [Kim, Chun-Ja] Ajou Univ, Coll Nursing, Dept Adult Hlth Nursing, Suwon 443721, South Korea.
   [Schlenk, Elizabeth A.] Univ Pittsburgh, Sch Nursing, Pittsburgh, PA 15261 USA.
   [Kang, Se-Won] Dong Eui Univ, Coll Nursing & Healthcare Sci, Pusan, South Korea.
   [Park, Jae-Bum] Ajou Univ, Coll Nursing, Dept Occupat & Environm Med, Suwon 443721, South Korea.
C3 Ajou University; Pennsylvania Commonwealth System of Higher Education
   (PCSHE); University of Pittsburgh; Dong-Eui University; Ajou University
RP Kim, CJ (corresponding author), Ajou Univ, Coll Nursing, NB 213,San 5, Suwon 443721, South Korea.
EM ckimha@ajou.ac.kr
RI Kim, Chun-Ja/HKF-2429-2023
OI KIM, Chun-Ja/0000-0002-7594-5418; Schlenk, Elizabeth/0000-0001-7361-1951
FU Basic Science Research Program of the National Research Foundation of
   Korea (NRF); Korean Ministry of Education, Science and Technology (MEST)
   [20100015339]; Department of Nursing, Graduate School, Ajou University
FX This research was supported by the Basic Science Research Program of the
   National Research Foundation of Korea (NRF), which is funded by the
   Korean Ministry of Education, Science and Technology (MEST; grant number
   20100015339) and Was partly supported by a grant in 2012 from Department
   of Nursing, Graduate School, Ajou University.
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NR 60
TC 14
Z9 17
U1 0
U2 16
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0738-3991
EI 1873-5134
J9 PATIENT EDUC COUNS
JI Patient Educ. Couns.
PD JAN
PY 2015
VL 98
IS 1
BP 111
EP 119
DI 10.1016/j.pec.2014.10.013
PG 9
WC Public, Environmental & Occupational Health; Social Sciences,
   Interdisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; Social Sciences - Other
   Topics
GA AX5FO
UT WOS:000346952400015
PM 25468401
DA 2025-06-11
ER

PT J
AU Vitale, E
AF Vitale, Elsa
TI A Chronic Inflammatory Inductive Condition in the Nursing Profession: A
   Scoping Review
SO ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS
LA English
DT Review
DE Body mass index; diet; inflammation; mental health; physical activity;
   nurses
ID BODY-MASS INDEX; TIME PHYSICAL-ACTIVITY; C-REACTIVE PROTEIN;
   ADIPOSE-TISSUE; CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; DEPRESSIVE
   SYMPTOMS; INSULIN-RESISTANCE; ANXIETY DISORDERS; OXIDATIVE STRESS
AB Background Literature focuses on the well-being of patients and little on the well-being of nurses who, in turn, should be educated about well-being. On the other hand, the latter often work under serious pressure with inadequate resources and shift organizations, exposing them to health risk factors. Objective To highlight which relationships exist between diet, physical activity, body mass index (BMI) and mental health in nursing. Methods The author searched the Medline (PubMed) database for medical subheadings terms and free full text referred to "Diet," "Mental Health," "Physical Activity," and "Nurses" before 31st December 2020. Results A total of 11 studies were included in this perspective review, which better defined the relationships between diet, physical activity, mental health and the nursing profession. Conclusion From the studies present in the literature, it emerges that the nursing profession has an inherent imbalance in the regular circadian activity of human nature, as nursing assistance is provided 24 hours a day and during the night. Numerous studies have highlighted significant differences between mental and eating disorder levels among nurses who work at night versus those who only work during the day. Therefore, it is possible to speak of the nursing profession as an "inductive inflammatory-chronic" activity based on the extensive scientific evidence provided by the literature.
C1 [Vitale, Elsa] Ctr Mental Hlth Modugno, Local Hlth Author Bari, Bari, Italy.
   [Vitale, Elsa] Via X Marzo 43, I-70026 Bari, Italy.
RP Vitale, E (corresponding author), Ctr Mental Hlth Modugno, Local Hlth Author Bari, Bari, Italy.; Vitale, E (corresponding author), Via X Marzo 43, I-70026 Bari, Italy.
EM vitaleelsa@libero.it
RI Vitale, Elsa/D-8904-2018
OI Vitale, Elsa/0000-0002-9738-3479
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NR 125
TC 3
Z9 3
U1 2
U2 6
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1871-5303
EI 2212-3873
J9 ENDOCR METAB IMMUNE
JI Endocr. Metab. Immune Disord.-Drug Targets
PY 2022
VL 22
IS 13
BP 1235
EP 1244
DI 10.2174/1871530322666220516163936
PG 10
WC Endocrinology & Metabolism; Immunology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Immunology; Pharmacology & Pharmacy
GA 7A9MU
UT WOS:000898771900002
PM 35578870
DA 2025-06-11
ER

PT J
AU Dent, KR
   Brennan, GM
   Khalifeh, L
   Richmond-Rakerd, LS
AF Dent, Kallisse R.
   Brennan, Grace M.
   Khalifeh, Lara
   Richmond-Rakerd, Leah S.
TI Midlife diseases of despair and cardiometabolic risk: testing shared
   origins in adolescent psychopathology
SO PSYCHOLOGICAL MEDICINE
LA English
DT Article
DE adolesecent psychopathology; cardiometabolic risk; diseases of despair;
   midlife morbidity
ID MENTAL-DISORDERS; CARDIOVASCULAR-DISEASE; LIFETIME PREVALENCE; US
   ADULTS; HEALTH; INEQUALITIES; INTELLIGENCE; MORTALITY; SYMPTOMS;
   BEHAVIOR
AB Background Rising midlife mortality in the United States is largely attributable to 'deaths of despair' (deaths from suicide, drug poisonings, and alcohol-related diseases) and deaths from cardiometabolic conditions. Although despair- and cardiometabolic-related mortality are increasing concurrently, it is unclear whether they share common developmental origins. We tested adolescent psychopathology as a potential common origin of midlife diseases of despair and cardiometabolic risk.Methods Participants (N = 4578) were from the National Longitudinal Study of Adolescent to Adult Health, a nationally representative cohort followed from adolescence to early midlife. Adolescent psychopathology included depression, anxiety, eating disorders, PTSD, conduct disorder, and ADHD at ages 11-18. Diseases of despair (suicidality, substance misuse, pain, and sleep problems) and cardiometabolic risk (hypertension, hyperlipidemia, high-risk waist circumference, diabetes, and cardiovascular conditions) were multi-modally measured at ages 33-43.Results At midlife, adolescents who experienced psychopathology exhibited more indicators of despair-related diseases and cardiometabolic risk (IRRs = 1.67 [1.46-1.87] and 1.13 [1.04-1.21], respectively), even after accounting for demographics, adolescent SES, and adolescent cognitive ability. Associations were evident for internalizing and externalizing conditions, and in a dose-response fashion. In mediation analyses, low education explained little of these associations, but early-adult substance use explained 21.5% of psychopathology's association with despair-related diseases. Midlife despair-related diseases and cardiometabolic risk co-occurred within individuals (IRR = 1.12 [1.08-1.16]). Adolescent psychopathology accounted for 8.3% of this co-occurrence, and 16.7% together with adolescent SES and cognitive ability.Conclusions Adolescent psychopathology precedes both diseases of despair and cardiometabolic risk. Prevention and treatment of psychopathology may mitigate multiple causes of poor midlife health, reducing premature mortality.
C1 [Dent, Kallisse R.; Khalifeh, Lara; Richmond-Rakerd, Leah S.] Univ Michigan, Dept Psychol, Ann Arbor, MI 48109 USA.
   [Brennan, Grace M.] Duke Univ, Dept Psychol & Neurosci, Durham, NC USA.
   [Brennan, Grace M.] Duke Univ, Duke Aging Ctr, Sch Med, Durham, NC USA.
C3 University of Michigan System; University of Michigan; Duke University;
   Duke University
RP Dent, KR (corresponding author), Univ Michigan, Dept Psychol, Ann Arbor, MI 48109 USA.
EM dentkr@umich.edu
RI Brennan, Grace/S-9042-2019
FU Eunice Kennedy Shriver National Institute of Child Health and Human
   Development (NICHD) [P01 HD31921]; National Institute on Aging (NIA) at
   the University of North Carolina at Chapel Hill [U01 AG071448,
   U01AG071450]; American Foundation for Suicide Prevention (LSR-R)
   [PRG-1-153-20]; NIA (KRD) [T32AG027708]; Duke Aging Center Postdoctoral
   Research Training Grant (GMB) [T32AG000029]
FX This research uses data from Add Health, funded by grant P01 HD31921
   (Harris) from the Eunice Kennedy Shriver National Institute of Child
   Health and Human Development (NICHD), with cooperative funding from 23
   other federal agencies and foundations. Add Health is currently directed
   by Robert A. Hummer and funded by the National Institute on Aging (NIA)
   cooperative agreements U01 AG071448 (Hummer)and U01AG071450 (Aiello and
   Hummer) at the University of North Carolina at Chapel Hill. Add Health
   was designed by J. Richard Udry, PeterS. Bearman, and Kathleen Mullan
   Harris at the University of North Carolina at Chapel Hill. Additional
   support was provided from the American Foundation for Suicide Prevention
   (LSR-R, PRG-1-153-20), the NIA (KRD, T32AG027708, PIs: Kobayashi and
   Park), and the Duke Aging Center Postdoctoral Research Training Grant
   (GMB, T32AG000029). This work's content is solely the responsibility of
   the authors and does not necessarily represent the official views of the
   funding agencies.
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NR 60
TC 1
Z9 1
U1 2
U2 4
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0033-2917
EI 1469-8978
J9 PSYCHOL MED
JI Psychol. Med.
PD AUG
PY 2024
VL 54
IS 11
BP 2866
EP 2875
DI 10.1017/S0033291724000916
EA APR 2024
PG 10
WC Psychology, Clinical; Psychiatry; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA R7C2F
UT WOS:001202788800001
PM 38618989
OA hybrid
DA 2025-06-11
ER

PT J
AU Ishino, FAM
   Canenguez, KM
   Cohen, JH
   Kent, BV
   Villalobos, K
   Needham, BL
   Kandula, NR
   Kanaya, AM
   Shields, AE
   Williams, F
AF Montiel Ishino, Francisco A.
   Canenguez, Katia M.
   Cohen, Jeffrey H.
   Kent, Blake Victor
   Villalobos, Kevin
   Needham, Belinda L.
   Kandula, Namratha R.
   Kanaya, Alka M.
   Shields, Alexandra E.
   Williams, Faustine
TI Profiles of cardiometabolic risk and acculturation indicators among
   South Asians in the US: latent class analysis of the MASALA study
SO FRONTIERS IN PUBLIC HEALTH
LA English
DT Article
DE cardiometabolic disease; South Asian; latent class analysis; social
   determinants of health; acculturation
ID DIETARY PATTERNS; MENTAL-HEALTH; UNITED-STATES; INDIANS; DISCRIMINATION;
   IMMIGRANTS; ATHEROSCLEROSIS; ASSOCIATION; PREVALENCE; MEDIATORS
AB Background South Asians (SA) represent the fastest growing US immigrant group, and previous studies have indicated that they face disproportionately high burden of cardiometabolic disease. Cardiometabolic disease manifests as a syndemic or synergistic epidemic encompassing multiple disease clusters influenced by biological, social, and psychological factors stemming from the acculturative process. This process may exacerbate morbidity within immigrant subgroups. Our aim was to identify cardiometabolic risk profiles among SA using indicators of acculturation.Methods We conducted a latent class analysis on data from the Mediators of Atherosclerosis in South Asians Living in America study (N=771). A composite cardiometabolic disease outcome was constructed using prevalent hypertension, type 2 diabetes, and body mass index. Acculturation indicators included years living in the US, English language proficiency, dietary behaviors, preservation of cultural traditions, social and neighborhood support, maintenance of social relationships (i.e., friendships), and experiences of discrimination, along with proxies of acculturative stress (i.e., depressive symptomology, trait anxiety and anger). Social and environmental determinants of health, health behaviors, religiosity and spirituality served as covariates to further assess latent class membership.Results Four cardiometabolic risk profiles emerged: (1) lowest risk [73.8% of sample] characterized by high integration into both SA and US cultures; (2) the modest risk [13.4% of sample], exhibiting elevated levels of mental health distress and experiences of discrimination, and distancing themselves from both cultures; and the (3) moderate risk [8.9% of sample] and (4) highest risk [3.9% of sample], demonstrating greater assimilation into US culture. Compared to the lowest risk profile: the modest risk profile was associated with low-income and conflicting attitudes about religion/spirituality, while the moderate risk profile was characterized by lower income and educational attainment with positive behaviors and attitudes toward religion/spirituality.Conclusion Findings expand our understanding of immigrant cardiometabolic health as a syndemic issue wherein multiple co-occurring and interacting processes synergize to produce negative outcomes in already at-risk subpopulations. Furthermore, acculturation emerges as a crucial factor in understanding health disparities among immigrant and refugee groups in the US.
C1 [Montiel Ishino, Francisco A.; Williams, Faustine] Natl Inst Minor Hlth & Hlth Dispar, Div Intramural Res, NIH, Bethesda, MD 20892 USA.
   [Montiel Ishino, Francisco A.; Villalobos, Kevin] NIEHS, Div Intramural Res, NIH, Durham, NC 27709 USA.
   [Canenguez, Katia M.; Kent, Blake Victor; Shields, Alexandra E.] Harvard Massachusetts Gen Hosp, Ctr Genom Vulnerable Populat & Hlth Dispar, Boston, MA USA.
   [Cohen, Jeffrey H.] Ohio State Univ, Dept Anthropol, Columbus, OH USA.
   [Kent, Blake Victor] Westmont Coll, Dept Sociol, Santa Barbara, CA USA.
   [Needham, Belinda L.] Univ Michigan, Dept Epidemiol, Ann Arbor, MI USA.
   [Kandula, Namratha R.] Northwestern Univ, Feinberg Sch Med, Inst Publ Hlth & Med, Ctr Community Hlth, Chicago, IL USA.
   [Kandula, Namratha R.] Northwestern Univ, Feinberg Sch Med, Dept Med, Chicago, IL USA.
   [Kanaya, Alka M.] Univ Calif San Francisco, Dept Med Epidemiol & Biostat, San Francisco, CA USA.
C3 National Institutes of Health (NIH) - USA; NIH National Institute on
   Minority Health & Health Disparities (NIMHD); Division of Intramural
   Research (DIR); National Institutes of Health (NIH) - USA; NIH National
   Institute of Environmental Health Sciences (NIEHS); Harvard University;
   Harvard University Medical Affiliates; Massachusetts General Hospital;
   University System of Ohio; Ohio State University; University of Michigan
   System; University of Michigan; Northwestern University; Feinberg School
   of Medicine; Northwestern University; Feinberg School of Medicine;
   University of California System; University of California San Francisco
RP Ishino, FAM (corresponding author), Natl Inst Minor Hlth & Hlth Dispar, Div Intramural Res, NIH, Bethesda, MD 20892 USA.; Ishino, FAM (corresponding author), NIEHS, Div Intramural Res, NIH, Durham, NC 27709 USA.
EM francisco.montielishino@nih.gov
RI Montiel Ishino, Francisco/I-2077-2016; Williams, Faustine/JCE-5252-2023
FU Division of Intramural Research; National Institute on Minority Health
   and Health Disparities [ZIA MD000015]; Division of Intramural Research
   at the National Institute on Minority Health and Health Disparities [ZIA
   MD000015]; Division of Intramural Research at the National Institute of
   Environmental Health Sciences [Z1A ES103325]; National Heart, Lung, and
   Blood Institute [R01HL093009, 2R01HL093009]; National Center for
   Research Resources; National Center for Advancing Translational
   Sciences, National Institutes of Health through University of California
   San Francisco Clinical and Translational Sciences Institute
   [UL1RR024131, UL1TR001872]; Northwestern University Clinical and
   Translational Sciences Institute [UL1TR001422]
FX The author(s) declare that financial support was received for the
   research, authorship, and/or publication of this article. This efforts
   of Williams were supported by the Division of Intramural Research, the
   National Institute on Minority Health and Health Disparities (ZIA
   MD000015). This efforts of Montiel Ishino and Villalobos were supported
   by the Division of Intramural Research at the National Institute on
   Minority Health and Health Disparities (ZIA MD000015) and Division of
   Intramural Research at the National Institute of Environmental Health
   Sciences (Z1A ES103325). The content was solely the responsibility of
   the authors and does not necessarily reflect the views of the National
   Institutes of Health. The MASALA study described in this work was
   supported by the National Heart, Lung, and Blood Institute (R01HL093009
   and 2R01HL093009), the National Center for Research Resources and the
   National Center for Advancing Translational Sciences, National
   Institutes of Health through University of California San Francisco
   Clinical and Translational Sciences Institute (UL1RR024131 and
   UL1TR001872), and the Northwestern University Clinical and Translational
   Sciences Institute (UL1TR001422). The use of these data does not imply
   the National Institutes of Health, University of California San
   Francisco, or Northwestern University agree or disagree with any
   presentations, analyses, interpretations, or conclusions herein, nor had
   any involvement with analyses, interpretations, conclusions, or
   manuscript development.
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NR 69
TC 0
Z9 0
U1 1
U2 1
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 2296-2565
J9 FRONT PUBLIC HEALTH
JI Front. Public Health
PD OCT 8
PY 2024
VL 12
AR 1384607
DI 10.3389/fpubh.2024.1384607
PG 16
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA J5X3N
UT WOS:001337788600001
PM 39440183
OA gold
DA 2025-06-11
ER

PT J
AU Babic, R
   Maslov, B
   Babic, D
   Vasilj, I
AF Babic, Romana
   Maslov, Boris
   Babic, Dragan
   Vasilj, Ivan
TI THE PREVALENCE OF METABOLIC SYNDROME IN PATIENT WITH POSTTRAUMATIC
   STRESS DISORDER
SO PSYCHIATRIA DANUBINA
LA English
DT Article
DE metabolic syndrome; components; war; post-traumatic stress disorder;
   prevalence
ID DEPRESSION
AB Background: Although the connection between body and soul is written in the Bible, research papers haven't given much attention to it until the past few decades. Recently, both here and abroad, there have been more studies that investigate the prevalence of various somatic disorders in psychiatric patients, including metabolic syndrome.
   Objective: The objective of this study was to establish the prevalence of metabolic syndrome and it's components in patients with posttraumatic stress disorder (PTSD).
   Subjects and methods: Metabolic syndrome and its components were investigated in 60 patients with chronic PTSD conditioned by the war and in 60 patients treated for somatic problems by their family physician in Mostar.
   Results: The prevalence of metabolic syndrome was statistically significantly higher in patients with PTSD (48.3%) than in the control group (25%) (P=0.008) and the number of its individual components (test group 2.38 +/- 1.30 compared to control group 1.72 +/- 1.24) (P=0.005). PTSD patients diagnosed with metabolic syndrome had significantly more frequent hyperglycemia (P=0.010) and abdominal obesity (P=0.044) compared to the control group.
   Conclusion: The prevalence of metabolic syndrome increased in patients with PTSD compared to the control group.
C1 [Babic, Romana; Maslov, Boris; Babic, Dragan; Vasilj, Ivan] Univ Mostar, Sch Med, Dept Psychiat, Mostar 88000, Bosnia & Herceg.
   [Maslov, Boris; Babic, Dragan] Univ Clin Hosp Mostar, Dept Psychiat, Mostar, Bosnia & Herceg.
C3 University of Mostar; University of Mostar
RP Babic, R (corresponding author), Univ Mostar, Sch Med, Dept Psychiat, Mostar 88000, Bosnia & Herceg.
EM dragan.babic@tel.net.ba
RI Vasilj, Ivan/LKK-2729-2024
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NR 20
TC 17
Z9 18
U1 0
U2 17
PU MEDICINSKA NAKLADA
PI ZAGREB
PA VLASKA 69, HR-10000 ZAGREB, CROATIA
SN 0353-5053
J9 PSYCHIAT DANUB
JI Psychiatr. Danub.
PY 2013
VL 25
SU 1
BP 45
EP 50
PG 6
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA AK7TZ
UT WOS:000338631900008
PM 23806967
DA 2025-06-11
ER

PT J
AU Zimmet, P
   Alberti, KGMM
   Stern, N
   Bilu, C
   El-Osta, A
   Einat, H
   Kronfeld-Schor, N
AF Zimmet, P.
   Alberti, K. G. M. M.
   Stern, N.
   Bilu, C.
   El-Osta, A.
   Einat, H.
   Kronfeld-Schor, N.
TI The Circadian Syndrome: is the Metabolic Syndrome and much more!
SO JOURNAL OF INTERNAL MEDICINE
LA English
DT Review
DE circadian clock; diabetes; metabolic syndrome
ID ANXIETY-LIKE BEHAVIORS; BLOOD-PRESSURE; LIGHT THERAPY; NONSEASONAL
   DEPRESSION; SAND RAT; COMORBID DEPRESSION; INSULIN-RESISTANCE;
   EPIGENETIC CHANGES; GENE-EXPRESSION; DIURNAL RODENTS
AB The Metabolic Syndrome is a cluster of cardio-metabolic risk factors and comorbidities conveying high risk of both cardiovascular disease and type 2 diabetes. It is responsible for huge socio-economic costs with its resulting morbidity and mortality in most countries. The underlying aetiology of this clustering has been the subject of much debate. More recently, significant interest has focussed on the involvement of the circadian system, a major regulator of almost every aspect of human health and metabolism. The Circadian Syndrome has now been implicated in several chronic diseases including type 2 diabetes and cardiovascular disease. There is now increasing evidence connecting disturbances in circadian rhythm with not only the key components of the Metabolic Syndrome but also its main comorbidities including sleep disturbances, depression, steatohepatitis and cognitive dysfunction. Based on this, we now propose that circadian disruption may be an important underlying aetiological factor for the Metabolic Syndrome and we suggest that it be renamed the 'Circadian Syndrome'. With the increased recognition of the 'Circadian Syndrome', circadian medicine, through the timing of exercise, light exposure, food consumption, dispensing of medications and sleep, is likely to play a much greater role in the maintenance of both individual and population health in the future.
C1 [Zimmet, P.; El-Osta, A.] Monash Univ, Cent Clin Sch, Dept Diabet, Melbourne, Vic, Australia.
   [Zimmet, P.; Stern, N.] Tel Aviv Med Ctr & Sch Med, Sagol Ctr Epigenet & Metab, Tel Aviv, Israel.
   [Alberti, K. G. M. M.] Imperial Coll, London, England.
   [Bilu, C.; Kronfeld-Schor, N.] Tel Aviv Univ, Sch Zool, Tel Aviv, Israel.
   [El-Osta, A.] Univ Melbourne, Dept Pathol, Parkville, Vic, Australia.
   [El-Osta, A.] Chinese Univ Hong Kong, Prince Wales Hosp, Hong Kong Inst Diabet & Obes, Hong Kong, Peoples R China.
   [Einat, H.] Tel Aviv Yaffo Acad Coll, Sch Behav Sci, Tel Aviv, Israel.
C3 Monash University; Tel Aviv University; Sackler Faculty of Medicine;
   Imperial College London; Tel Aviv University; University of Melbourne;
   Chinese University of Hong Kong; Prince of Wales Hospital
RP Zimmet, P (corresponding author), Monash Diabet, Alfred Ctr, Level 5,99 Commercial Rd, Melbourne, Vic 3004, Australia.
EM paul.zimmet@monash.edu
RI Kronfeld-Schor, Noga/AAU-3792-2020; Zimmet, Paul/H-7635-2013; Einat,
   Haim/AAZ-9746-2020
OI El-Osta, Assam/0000-0003-2969-9137; Kronfeld-Schor,
   Noga/0000-0002-5224-3341
FU Israel Science Foundation [866/17]
FX This research was supported by the Israel Science Foundation grant (No.
   866/17) to NKS.
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NR 110
TC 206
Z9 221
U1 10
U2 63
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0954-6820
EI 1365-2796
J9 J INTERN MED
JI J. Intern. Med.
PD AUG
PY 2019
VL 286
IS 2
BP 181
EP 191
DI 10.1111/joim.12924
PG 11
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA IJ0YB
UT WOS:000475624800004
PM 31081577
OA Green Published, hybrid
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Zimmermann, MB
   Aeberli, I
AF Zimmermann, M. B.
   Aeberli, I.
TI Dietary determinants of subclinical inflammation, dyslipidemia and
   components of the metabolic syndrome in overweight children: a review
SO INTERNATIONAL JOURNAL OF OBESITY
LA English
DT Article; Proceedings Paper
CT 4th Fribourg Obesity Research Conference
CY SEP 14, 2007
CL Fribourg, SWITZERLAND
DE child; metabolic syndrome; diet; inflammation; adipokine
ID C-REACTIVE PROTEIN; TUMOR-NECROSIS-FACTOR; RETINOL-BINDING-PROTEIN;
   LOW-DENSITY-LIPOPROTEIN; POLYUNSATURATED FATTY-ACIDS; GRADE SYSTEMIC
   INFLAMMATION; CARDIOVASCULAR RISK-FACTORS; INSULIN-RESISTANCE SYNDROME;
   INCREASED OXIDATIVE STRESS; VITAMIN-A-DEFICIENCY
AB Objective: To review and summarize the dietary determinants of the metabolic syndrome, subclinical inflammation and dyslipidemia in overweight children.
   Design: Review of the current literature, focusing on pediatric studies.
   Participants: Normal weight, overweight, or obese children and adolescents.
   Results: There is a growing literature on the metabolic effects of excess body fat during childhood. However, few pediatric studies have examined the dietary determinants of obesity-related metabolic disturbances. From the available data, it appears that dietary factors are not only important environmental determinants of adiposity, but also may affect components of the metabolic syndrome and modulate the actions of adipokines. Dietary total fat and saturated fat are associated with insulin resistance and high blood pressure, as well as obesity-related inflammation. In contrast to studies in adults, resistin and adiponectin do not appear to be closely linked to insulin resistance or dyslipidemia in childhood. However, circulating leptin and retinol-binding protein (RBP) 4 correlate well with obesity, central obesity and the metabolic syndrome in children. Intakes of antioxidant vitamins tend to be low in obese children and may be predictors of subclinical inflammation. Higher fructose intake from sweets and sweetened drinks in overweight children has been linked to decreased low-density lipoprotein (LDL) particle size.
   Conclusions: Dietary interventions aimed at reducing intakes of total fat, saturated fat and free fructose, whereas increasing antioxidant vitamin intake may be beneficial in overweight children. More research on the relationships between dietary factors and the metabolic changes of pediatric obesity may help to identify the dietary changes to reduce health risks.
C1 [Zimmermann, M. B.; Aeberli, I.] ETH, Human Nutr Lab, Inst Food Sci & Nutr, CH-8092 Zurich, Switzerland.
   [Zimmermann, M. B.] Wageningen Univ, Div Human Nutr, Wageningen, Netherlands.
C3 Swiss Federal Institutes of Technology Domain; ETH Zurich; Wageningen
   University & Research
RP Zimmermann, MB (corresponding author), ETH, Human Nutr Lab, Inst Food Sci & Nutr, LFV E19,Schmelzbergstr 7, CH-8092 Zurich, Switzerland.
EM michael.zimmermann@ilw.agrl.ethz.ch
RI Zimmermann, Michael/C-3062-2016; Herter-Aeberli, Isabelle/C-8580-2013
OI Herter-Aeberli, Isabelle/0000-0003-0134-6217
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NR 143
TC 50
Z9 57
U1 0
U2 5
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0307-0565
EI 1476-5497
J9 INT J OBESITY
JI Int. J. Obes.
PD DEC
PY 2008
VL 32
SU 6
BP S11
EP S18
DI 10.1038/ijo.2008.202
PG 8
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 384AY
UT WOS:000261717100003
PM 19079275
DA 2025-06-11
ER

PT J
AU Jacobsen, HB
   Reme, SE
   Sembajwe, G
   Hopcia, K
   Stiles, TC
   Sorensen, G
   Porter, JH
   Marino, M
   Buxton, OM
AF Jacobsen, Henrik B.
   Reme, Silje E.
   Sembajwe, Grace
   Hopcia, Karen
   Stiles, Tore C.
   Sorensen, Glorian
   Porter, James H.
   Marino, Miguel
   Buxton, Orfeu M.
TI Work Stress, Sleep Deficiency, and Predicted 10-Year Cardiometabolic
   Risk in a Female Patient Care Worker Population
SO AMERICAN JOURNAL OF INDUSTRIAL MEDICINE
LA English
DT Article
DE cardiometabolic risk; nurses; sleep maintenance; physical activity;
   follow-up; work-family conflict
ID CORONARY-HEART-DISEASE; ALL-CAUSE MORTALITY; PHYSICAL-ACTIVITY; SHIFT
   WORK; CARDIOVASCULAR-DISEASE; DURATION; OBESITY; ASSOCIATION; ADULTS;
   HYPERTENSION
AB Objectives The aim of this study was to investigate the longitudinal effect of work-related stress, sleep deficiency, and physical activity on 10-year cardiometabolic risk among an all-female worker population.
   Methods Data on patient care workers (n = 99) was collected 2 years apart. Baseline measures included: job stress, physical activity, night work, and sleep deficiency. Biomarkers and objective measurements were used to estimate 10-year cardiometabolic risk at follow-up. Significant associations (P < 0.05) from baseline analyses were used to build a multivariable linear regression model.
   Results The participants were mostly white nurses with a mean age of 41 years. Adjusted linear regression showed that having sleep maintenance problems, a different occupation than nurse, and/or not exercising at recommended levels at baseline increased the 10-year cardiometabolic risk at follow-up.
   Conclusions In female workers prone to work-related stress and sleep deficiency, maintaining sleep and exercise patterns had a strong impact on modifiable 10-year cardiometabolic risk. (C) 2014 Wiley Periodicals, Inc.
C1 [Jacobsen, Henrik B.; Reme, Silje E.; Hopcia, Karen; Sorensen, Glorian; Buxton, Orfeu M.] Harvard Univ, Sch Publ Hlth, Ctr Work Hlth & Wellbeing, Boston, MA 02115 USA.
   [Jacobsen, Henrik B.; Stiles, Tore C.] Norwegian Univ Sci & Technol, N-7034 Trondheim, Norway.
   [Reme, Silje E.] Uni Res, Uni Hlth, Bergen, Norway.
   [Sembajwe, Grace] CUNY, Sch Publ Hlth, Hunter Coll, New York, NY 10021 USA.
   [Sembajwe, Grace; Hopcia, Karen] Partners Hlth Care Syst, Partners Occupat Hlth Serv, Boston, MA USA.
   [Sorensen, Glorian] Harvard Univ, Sch Publ Hlth, Dept Soc Hlth & Human Dev, Boston, MA 02115 USA.
   [Sorensen, Glorian] Dana Farber Canc Inst, Boston, MA 02115 USA.
   [Porter, James H.; Buxton, Orfeu M.] Brigham & Womens Hosp, Dept Med, Boston, MA 02115 USA.
   [Marino, Miguel] Oregon Hlth & Sci Univ, Div Biostat, Dept Family Med Publ Hlth & Prevent Med, Portland, OR 97201 USA.
   [Buxton, Orfeu M.] Harvard Univ, Sch Med, Div Sleep Med, Boston, MA USA.
C3 Harvard University; Harvard T.H. Chan School of Public Health; Norwegian
   University of Science & Technology (NTNU); City University of New York
   (CUNY) System; Hunter College (CUNY); Partners Healthcare System;
   Harvard University; Harvard T.H. Chan School of Public Health; Harvard
   University; Harvard University Medical Affiliates; Dana-Farber Cancer
   Institute; Harvard University; Harvard University Medical Affiliates;
   Brigham & Women's Hospital; Oregon Health & Science University; Harvard
   University; Harvard Medical School
RP Jacobsen, HB (corresponding author), NTNU, Fac Med, Dept Circulat & Med Imaging, POB 8905 MTFS, N-7491 Trondheim, Norway.
EM henrik.b.jacobsen@ntnu.no
RI Reme, Silje/K-5206-2018; Sembajwe, Grace/H-3288-2017
OI Stiles, Tore C./0000-0001-5853-6674; Sembajwe,
   Grace/0000-0002-7163-4743; Jacobsen, Henrik/0000-0001-5329-0003; Hopcia,
   Karen/0000-0001-9724-5634; Buxton, Orfeu/0000-0001-5057-633X
FU National Institute for Occupational Safety and Health [U19OH008861];
   National Center for Research Resources [UL1RR025758-04]; Work, Family,
   and Health Network [U01AG5186989]; National Heart, Lung, and Blood
   Institute [R01HL107240]; Dean Hashimoto and Partners Occupational Health
   Service
FX Contract grant sponsor: National Institute for Occupational Safety and
   Health; Contract grant number: U19OH008861; Contract grant sponsor:
   National Center for Research Resources. Grant number; Contract grant
   number: UL1RR025758-04; Contract grant sponsor: Work, Family, and Health
   Network; Contract grant number: U01AG5186989; Contract grant sponsor:
   National Heart, Lung, and Blood Institute; Contract grant number:
   R01HL107240; Contract grant sponsor: Dean Hashimoto and Partners
   Occupational Health Service.
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NR 65
TC 24
Z9 28
U1 0
U2 31
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0271-3586
EI 1097-0274
J9 AM J IND MED
JI Am. J. Ind. Med.
PD AUG
PY 2014
VL 57
IS 8
BP 940
EP 949
DI 10.1002/ajim.22340
PG 10
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA AM9EH
UT WOS:000340182800009
PM 24809311
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Gawlik-Kotelnicka, O
   Margulska, A
   Skowronska, A
   Strzelecki, D
AF Gawlik-Kotelnicka, Oliwia
   Margulska, Aleksandra
   Skowronska, Anna
   Strzelecki, Dominik
TI PRO-DEMET Randomized Controlled Trial on Probiotics in Depression-Pilot
   Study Results
SO NUTRIENTS
LA English
DT Article
DE depression; metabolic syndrome; probiotics; feasibility; pilot study
ID POSTMYOCARDIAL INFARCTION DEPRESSION; METABOLIC SYNDROME; GUT
   MICROBIOTA; PSYCHOMETRIC PROPERTIES; CONSENSUS STATEMENT; DOUBLE-BLIND;
   METAANALYSIS; DISORDER; SUPPLEMENTATION; ASSOCIATION
AB There is a pressing need to identify new treatment options for depression and its comorbidities. Depression often coexists with metabolic complications, and the two may share a pathophysiological overlap, including inflammation and microbiota changes. Microbiota interventions (e.g., probiotics) may represent a safe and easy-to-use treatment option as an adjunctive therapy in patients only partially responsive to pharmacologic treatment. (1) Objective: The paper presents the results of a feasibility and pilot study. The study is an internal part of a randomized controlled trail (RCT) of the effect of probiotic supplementation on psychometric, anthropometric, metabolic, and inflammatory parameters in adult patients with depressive disorders depending on the presence of metabolic syndrome. (2) Methods: The trial has a four-arm, parallel-group, prospective, randomized, double-blind, controlled design. Sixty participants received a probiotic preparation containing Lactobacillus helveticus Rosell(R)-52 and Bifidobacterium longum Rosell(R)-175 over 60 days. The feasibility of the study design was assessed, as well as the rates of recruitment, eligibility, consent, and study completion. The following were assessed: depressive, anxiety and stress symptoms, quality of life, blood pressure, body mass index and waist circumference, complete blood count with differential, serum levels of C-reactive protein, high-density lipoprotein cholesterol, triglycerides, fasting glucose, some secondary markers of inflammation and metabolic health, as well as noninvasive biomarkers of liver fibrosis (APRI and FIB-4). (3) Results: The study was found to be generally feasible. The eligibility rate was 52% of recruited participants with 80% completing the study protocol. No differences in sociodemographic or anthropometric factors or basic laboratory findings were found between the placebo and probiotic group at the start of the intervention period. Importantly, the proportion of recruited participants fulfilling the criteria of metabolic syndrome was too low. (4) Conclusions: Whilst the whole study protocol was feasible, some different timepoint procedures require modification. The major weakness of the recruitment methods was that the percentage of metabolic arms participants was insufficient. Overall, the full RCT design on probiotics in depression with vs. without metabolic syndrome was shown to be feasible with little modification.
C1 [Gawlik-Kotelnicka, Oliwia; Skowronska, Anna; Strzelecki, Dominik] Med Univ Lodz, Dept Affect & Psychot Disorders, PL-92216 Lodz, Poland.
   [Margulska, Aleksandra] Med Univ Lodz, Dept Adolescent Psychiat, PL-92216 Lodz, Poland.
C3 Medical University Lodz; Medical University Lodz
RP Gawlik-Kotelnicka, O (corresponding author), Med Univ Lodz, Dept Affect & Psychot Disorders, PL-92216 Lodz, Poland.
EM oliwia.gawlik@umed.lodz.pl
RI Strzelecki, Dominik/S-9340-2016; Gawlik-Kotelnicka,
   Oliwia/ITU-7979-2023; Gawlik-Kotelnicka, Oliwia/S-9936-2016
OI Gawlik-Kotelnicka, Oliwia/0000-0003-1398-3117; Strzelecki,
   Dominik/0000-0002-8559-1078; Margulska, Aleksandra/0000-0003-1229-0925
FU Medical University of Lodz [503/1-155-02/503-11-003-20,
   502-03/1-155-02/502-14-386-18]
FX This research was funded by the Medical University of Lodz, grant number
   503/1-155-02/503-11-003-20 and 502-03/1-155-02/502-14-386-18.
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NR 79
TC 7
Z9 7
U1 7
U2 23
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD MAR
PY 2023
VL 15
IS 6
AR 1400
DI 10.3390/nu15061400
PG 18
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA C0MV5
UT WOS:000958973900001
PM 36986132
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Guedes, EP
   Madeira, E
   Mafort, TT
   Madeira, M
   Moreira, RO
   Mendonça, LMC
   Godoy-Matos, AF
   Lopes, AJ
   Farias, MLF
AF Guedes, Erika P.
   Madeira, Eduardo
   Mafort, Thiago T.
   Madeira, Miguel
   Moreira, Rodrigo O.
   Mendonca, Laura Maria C.
   Godoy-Matos, Amelio F.
   Lopes, Agnaldo J.
   Farias, Maria Lucia F.
TI Impact of a 6-month treatment with intragastric balloon on body
   composition and psychopathological profile in obese individuals with
   metabolic syndrome
SO DIABETOLOGY & METABOLIC SYNDROME
LA English
DT Article
DE Obesity; Depression; Anxiety; Body composition; Intragastric balloon
ID QUALITY-OF-LIFE; BEHAVIORAL WEIGHT-LOSS; X-RAY ABSORPTIOMETRY; BARIATRIC
   SURGERY; DEPRESSIVE SYMPTOMS; MORBID-OBESITY; MASS INDEX; MOOD
   DISORDERS; ANXIETY; WOMEN
AB Background: The aim of this study was to investigate the effects of a 6-month treatment with intragastric balloon (IGB) on body composition and depressive/anxiety symptoms in obese individuals with metabolic syndrome (MS).
   Methods: Fifty patients (aged 18-50 years) with obesity and MS were selected for treatment with IGB for 6 months. Body composition was verified with dual-energy X-ray absorptiometry (DXA) at baseline and right after IGB removal. Anxiety/depressive symptoms were assessed with the Beck Depression Inventory (BDI) and the hospital anxiety and depression scale (HADS) at baseline and after 6 months of treatment.
   Results: In total, 39 patients completed the study. After 6 months, there were significant decreases in weight (11.7 +/- 9.6 kg, p < 0.0001) and waist circumference (9.3 +/- 8.2 cm, p < 0.0001). Weight loss was also demonstrated by DXA and corresponded to decreases of 3.0 +/- 3.4% in body fat percentage, 7.53 +/- 7.62 kg in total body fat, and 3.70 +/- 4.89 kg in lean body mass (p < 0.001 for all comparisons). Depressive symptoms scores decreased by a mean of 4.57 +/- 10.6 points when assessed with the BDI (p = 0.002) and 1.82 +/- 5.16 points when assessed with the HADS-Depression (p = 0.0345). Anxiety symptoms scores decreased by a mean of 1.84 +/- 4.04 points when determined with the HADS-anxiety (p = 0.0066). The decrease in body fat percentage was the parameter that best correlated with improvements in depressive (p = 0.008) and anxiety symptoms (p = 0.014).
   Conclusions: In obese individuals with MS, fat mass reduction was associated with short-term improvements in depressive and anxiety symptoms.
C1 [Guedes, Erika P.; Moreira, Rodrigo O.; Godoy-Matos, Amelio F.] State Inst Diabet & Endocrinol IEDE, Div Metabol, Rua Moncorvo Filho 90 Ctr, BR-20211340 Rio De Janeiro, RJ, Brazil.
   [Guedes, Erika P.; Madeira, Eduardo; Madeira, Miguel; Moreira, Rodrigo O.; Farias, Maria Lucia F.] Univ Fed Rio de Janeiro, Div Endocrinol, Rio De Janeiro, Brazil.
   [Madeira, Eduardo] Univ Estado Rio De Janeiro, Div Gastroenterol, Rio De Janeiro, Brazil.
   [Mafort, Thiago T.; Lopes, Agnaldo J.] Univ Estado Rio De Janeiro, Div Pulmonol, Rio De Janeiro, Brazil.
   [Mendonca, Laura Maria C.] Univ Fed Rio de Janeiro, Div Rheumatol, Rio De Janeiro, Brazil.
C3 Universidade Federal do Rio de Janeiro; Universidade do Estado do Rio de
   Janeiro; Universidade do Estado do Rio de Janeiro; Universidade Federal
   do Rio de Janeiro
RP Guedes, EP (corresponding author), State Inst Diabet & Endocrinol IEDE, Div Metabol, Rua Moncorvo Filho 90 Ctr, BR-20211340 Rio De Janeiro, RJ, Brazil.
EM erikapaniago@uol.com.br
RI Lopes, Agnaldo/B-6430-2016; Moreira, Rodrigo/N-7131-2015; Lopes, Agnaldo
   Jose/AAB-5944-2019
OI Guedes, ERIKA/0000-0003-4430-8069; Lopes, Agnaldo
   Jose/0000-0001-8598-4878; Godoy-Matos, Amelio/0000-0001-9089-9889
CR [Anonymous], INT J OBES LOND
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NR 50
TC 8
Z9 9
U1 0
U2 13
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1758-5996
J9 DIABETOL METAB SYNDR
JI Diabetol. Metab. Syndr.
PD DEC 19
PY 2016
VL 8
AR 81
DI 10.1186/s13098-016-0197-6
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA EG1TG
UT WOS:000390814600001
PM 28031749
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Fulop, T
   Tessier, D
   Carpentier, A
AF Fulop, T.
   Tessier, D.
   Carpentier, A.
TI The metabolic syndrome
SO PATHOLOGIE BIOLOGIE
LA English
DT Review
DE insulin resistance; obesity; inflammation; adipose tissue; cytokines;
   aging innate immunity
ID TUMOR-NECROSIS-FACTOR; C-REACTIVE PROTEIN; ENDOPLASMIC-RETICULUM STRESS;
   INSULIN-RESISTANCE SYNDROME; PANEL-III CRITERIA; ADIPOSE-TISSUE;
   SKELETAL-MUSCLE; INFLAMMATORY MARKERS; OXIDATIVE STRESS; FATTY-ACIDS
AB The metabolic syndrome (MS) is a cluster of metabolic abnormalities leading to increased risk for cardiovascular diseases and diabetes type 2. Its prevalence is increasing with aging. There exists actually an epidemic of MS. Visceral obesity and the resulting insulin resistance (IR) are the major determinant in the development of the MS. Abdominal obesity results in a low grade inflammation via the adipose tissue and macrophages secreted adipokines. This inflammation, via the generated pro-inflammatory molecules, interferes with the normal insulin signalling and thus contributes to the etiopathogenesis of the MS. Large clinical studies showed that CRP is increased in obese subjects and concomitantly to the number of existing component of the MS. Treatment of the MS is aimed to improve the IR by lifestyle changes including exercise and diet alone or in combination with medication targeting the individual components but having also anti-inflammatory actions.. More research is needed to bring new therapies to be able to decrease the incidence and prevalence of the MS among the population and thus increasing their quality of life. (c) 2006 Elsevier Masson SAS. All rights reserved.
C1 Univ Sherbrooke, Res Ctr Aging, Grad Program Immunol, Fac Med, 1036 Rue Blevedere Sud, Sherbrooke, PQ J1H 4C4, Canada.
   Univ Sherbrooke, Div Geriatr, Fac Med, Sherbrooke, PQ J1H 4C4, Canada.
   Univ Sherbrooke, Clin Res Ctr, Fac Med, Sherbrooke, PQ J1H 4C4, Canada.
   Univ Sherbrooke, Div Endocrinol, Fac Med, Sherbrooke, PQ J1H 4C4, Canada.
C3 University of Sherbrooke; University of Sherbrooke; University of
   Sherbrooke; University of Sherbrooke
RP Fulop, T (corresponding author), Univ Sherbrooke, Res Ctr Aging, Grad Program Immunol, Fac Med, 1036 Rue Blevedere Sud, Sherbrooke, PQ J1H 4C4, Canada.
EM tamas.fulop@usherbrooke.ca
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NR 124
TC 108
Z9 129
U1 0
U2 8
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0369-8114
J9 PATHOL BIOL
JI Pathol. Biol.
PD SEP
PY 2006
VL 54
IS 7
BP 375
EP 386
DI 10.1016/j.patbio.2006.07.002
PG 12
WC Pathology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pathology
GA 097CO
UT WOS:000241424200002
PM 16904849
DA 2025-06-11
ER

PT J
AU Dehesh, T
   Mosleh-Shirazi, MA
   Dehesh, P
AF Dehesh, Tania
   Mosleh-Shirazi, Mohammad Amin
   Dehesh, Paria
TI Prevalence and associated factors of anxiety and depression among
   patients with hypothyroidism in Southern Iran
SO BMC PSYCHIATRY
LA English
DT Article
DE Anxiety; Depression; Hypothyroidism; Hamilton questionnaire; Beck
   questionnaire
ID METABOLIC SYNDROME; POPULATION; DISORDERS
AB PurposeDepression and anxiety are the main disorders in patients suffering from hypothyroidism. These disorders can lead to increased patient suffering. Since hypothyroidism is one of the most prevalent endocrine diseases, controlling the metabolic variables that increase the severity of anxiety and depression is important. This study aimed to assess the prevalence of anxiety and depression and to identify their associated factors, including metabolic variables, among people with hypothyroidism.Patients and methodsWe performed a cross-sectional study of 1,600 patients with hypothyroidism in Kerman, the southern part of Iran. The prevalence of depression and anxiety was estimated using the Beck Depression Inventory and the Hamilton Anxiety questionnaires, respectively. First, univariate logistic regression was performed. Factors whose P-values were smaller than 0.2 in univariate logistic regression were included in multiple logistic regression for confounder adjustments. The analysis was performed using SPSS version 20.ResultsThe rates of depression and anxiety were 59% (95% CI: 53.18-62.11) and 63% (95% CI: 58.42-67.22), respectively. Factors found to be independently associated with anxiety were high TSH, high LDL, high TG, high FBS, high TGAb, high TPoAb, high TC, and hypertension. For depression, high TSH, high LDL, high TG, high FBS, high TC, and hypertension were identified. High TGAb and high TPoAb were independently associated with anxiety but not with depression.ConclusionsStudy findings revealed that a large proportion of patients with hypothyroidism suffer from depression and anxiety. This study also identified factors associated with these disorders. Controlling some metabolic variables may decrease the prevalence and severity of these disorders, help patients with better treatment, and improve their quality of life.
C1 [Dehesh, Tania] Kerman Univ Med Sci, Inst Futures Studies Hlth, Modeling Hlth Res Ctr, Kerman, Iran.
   [Dehesh, Paria] Kerman Univ Med Sci, Inst Futures Studies Hlth, Social Determinants Hlth Res Ctr, Kerman, Iran.
   [Mosleh-Shirazi, Mohammad Amin] Shiraz Univ Med Sci, Ionizing & Nonionizing Radiat Protect Res Ctr INIR, Sch Paramed Sci, Shiraz, Iran.
   [Mosleh-Shirazi, Mohammad Amin] Shiraz Univ Med Sci, Sch Med, Dept Radiooncol, Shiraz, Iran.
   [Dehesh, Tania; Dehesh, Paria] Kerman Univ Med Sci, Sch Publ Hlth, Dept Biostat & Epidemiol, Kerman, Iran.
C3 Kerman University of Medical Sciences; Kerman University of Medical
   Sciences; Shiraz University of Medical Science; Shiraz University of
   Medical Science; Kerman University of Medical Sciences
RP Dehesh, P (corresponding author), Kerman Univ Med Sci, Inst Futures Studies Hlth, Social Determinants Hlth Res Ctr, Kerman, Iran.; Dehesh, P (corresponding author), Kerman Univ Med Sci, Sch Publ Hlth, Dept Biostat & Epidemiol, Kerman, Iran.
EM Paria_dehesh@yahoo.com
RI Mosleh-Shirazi, Mohammad/L-9212-2016; Dehesh, Tania/AAN-9801-2020
CR Abbasi Shavazi M., 2010, J Popul Association Iran, V5, P77
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NR 46
TC 1
Z9 1
U1 0
U2 0
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-244X
J9 BMC PSYCHIATRY
JI BMC Psychiatry
PD JAN 20
PY 2025
VL 25
IS 1
AR 54
DI 10.1186/s12888-025-06490-3
PG 9
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychiatry
GA T0K4L
UT WOS:001402000800005
PM 39833737
OA gold
DA 2025-06-11
ER

PT J
AU Jiang, YP
   Boylan, JM
   Zilioli, S
AF Jiang, Yanping
   Boylan, Jennifer Morozink
   Zilioli, Samuele
TI Effects of the Great Recession on Educational Disparities in
   Cardiometabolic Health
SO ANNALS OF BEHAVIORAL MEDICINE
LA English
DT Article
DE Great Recession; Metabolic syndrome; Inflammation; Psychological
   distress; Education; Socioeconomic status
ID CARDIOVASCULAR-DISEASE; SOCIOECONOMIC-STATUS; METABOLIC SYNDROME;
   AFRICAN-AMERICANS; US ADULTS; TRENDS; MORTALITY; MARKERS; RISK;
   INEQUALITIES
AB Background Macroeconomic crises can exaggerate existing educational disparities in health. Few studies, however, have examined whether macroeconomic crises get under the skin to affect educational disparities in health-related biological processes. Purpose This study aimed to examine the effect of the economic recession of 2008 (i.e., Great Recession) on educational disparities in cardiometabolic risk and self-reported psychological distress. Methods Data were drawn from two subsamples of the Midlife in the United States (MIDUS) study: the second wave of the MIDUS sample (pre-recession cohort, N = 985) and the refresher sample (post-recession cohort, N = 863). Educational attainment was categorized into high school education or less, some college, and bachelor's degree or higher. Outcomes included metabolic syndrome, C-reactive protein, and interleukin-6, as well as self-reported perceived stress, depressive symptoms, and financial distress. Results Results showed that having a bachelor's degree or higher (compared to having a high school education or less) was more strongly associated with decreased metabolic syndrome symptoms in the post-recession cohort than the pre-recession cohort, above and beyond demographic, health, and behavioral covariates. These findings did not extend to systemic inflammation or psychological distress. Conclusions Our findings suggest that chronic macroeconomic stressors may widen the educational gap in physical health, particularly cardiometabolic health, by modifying biological and anthropometric risk factors implicated in metabolic syndrome.
C1 [Jiang, Yanping; Zilioli, Samuele] Wayne State Univ, Dept Psychol, 71 W Warren Ave, Detroit, MI 48202 USA.
   [Boylan, Jennifer Morozink] Univ Colorado, Dept Hlth & Behav Sci, Denver, CO 80202 USA.
   [Zilioli, Samuele] Wayne State Univ, Dept Family Med & Publ Hlth Sci, Detroit, MI USA.
C3 Wayne State University; University of Colorado System; University of
   Colorado Denver; Wayne State University
RP Jiang, YP (corresponding author), Wayne State Univ, Dept Psychol, 71 W Warren Ave, Detroit, MI 48202 USA.
EM yanping.jiang@wayne.edu
RI Jiang, Yanping/ABC-6916-2021; Boylan, Jennifer/B-9288-2016
OI Jiang, Yanping/0000-0002-0931-9507; Zilioli, Samuele/0000-0002-1126-8913
FU National Institute on Aging at the National Institutes of Health
   [P01-AG020166]; John D. and Catherine T. MacArthur Foundation Research
   Network on Successful Midlife Development; General Clinical Research
   Centers Program of the National Center for Research Resources, National
   Institutes of Health [M01- RR023942, M01- RR00865]; Clinical and
   Translational Science Award (CTSA) program of the National Center for
   Research Resources, National Institutes of Health [1UL1RR025011]; Wayne
   State University
FX Data collection for the present study was supported by the National
   Institute on Aging at the National Institutes of Health (P01-AG020166)
   and the John D. and Catherine T. MacArthur Foundation Research Network
   on Successful Midlife Development. Support also came from the following
   grants: M01- RR023942 (Georgetown), M01- RR00865 (UCLA) from the General
   Clinical Research Centers Program, and 1UL1RR025011 (UW) from the
   Clinical and Translational Science Award (CTSA) program of the National
   Center for Research Resources, National Institutes of Health. The
   preparation of the manuscript was partly supported by a Faculty
   Competition for Postdoctoral Fellowship from Wayne State University
   (Samuele Zilioli).
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NR 64
TC 1
Z9 1
U1 1
U2 7
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0883-6612
EI 1532-4796
J9 ANN BEHAV MED
JI Ann. Behav. Med.
PD MAY 18
PY 2022
VL 56
IS 5
BP 428
EP 441
DI 10.1093/abm/kaab065
EA JUL 2021
PG 14
WC Psychology, Multidisciplinary
WE Social Science Citation Index (SSCI)
SC Psychology
GA 1I3QZ
UT WOS:000756329000001
PM 34323265
OA Green Published
DA 2025-06-11
ER

PT J
AU Chedraui, P
   Miguel, GS
   Villacreses, D
   Dominguez, A
   Jaramillo, W
   Escobar, GS
   Pérez-López, FR
   Genazzani, AR
   Simoncini, T
AF Chedraui, Peter
   Miguel, Glenda San
   Villacreses, Diego
   Dominguez, Andrea
   Jaramillo, Winston
   Escobar, Gustavo S.
   Perez-Lopez, Faustino R.
   Genazzani, Andrea R.
   Simoncini, Tommaso
CA Res Grp Omega Women's Hlth Project
TI Assessment of insomnia and related risk factors in postmenopausal women
   screened for the metabolic syndrome
SO MATURITAS
LA English
DT Article
DE Postmenopause; Insomnia; Sleep problems; Metabolic syndrome; Athens
   insomnia scale; Hospital anxiety and depression scale
ID MENOPAUSAL TRANSITION; VASOMOTOR SYMPTOMS; SLEEP DURATION; HOT FLASHES;
   SHIFT WORK; MIDLIFE; DEPRESSION; ASSOCIATION; PREVALENCE; DISORDERS
AB Background: Sleep disturbances are common during female mid-life. Nevertheless, there is limited available information linking sleep characteristics to the menopause and the metabolic syndrome (METS).
   Objective: To assess insomnia prevalence and related risk factors in postmenopausal women screened for the METS.
   Methods: In this cross sectional study 204 natural postmenopausal women participating in a METS screening program filled out the Athens insomnia scale (AIS), the hospital anxiety and depression scale (HADS) and a general socio-demographic questionnaire. Criteria of the Adult Treatment Panel III (ATP-III) were used to define the METS.
   Results: Median age of the whole sample was 56 years. A 50.5% of women had the METS, 57.4% hot flushes, 58.3% were abdominally obese, 51.5% hypertension, 25.0% hyperglycemia, 15.7% depressed mood and 29.9% anxiety. A33.8% presented insomnia according to the AIS (scores 6 or more). The AIS displayed a high internal consistency as computed Cronbach's alpha was determined to be 0.86. Multiple linear regression analysis determined that male premature ejaculation, female psychotropic drug use, hot flush intensity, mood morbidity (higher total HADS scores) and higher parity positively and significantly correlated to higher AIS scores (more insomnia).
   Conclusion: In this postmenopausal sample insomnia was not related to the METS or its components yet to other psycho-somatic female and partner issues. (c) 2012 Elsevier Ireland Ltd. All rights reserved.
C1 [Chedraui, Peter; Miguel, Glenda San; Villacreses, Diego; Dominguez, Andrea; Jaramillo, Winston; Escobar, Gustavo S.] Univ Catolica Santiago Guayaquil, Fac Ciencias Med, Inst Biomed, Guayaquil, Ecuador.
   [Perez-Lopez, Faustino R.] Univ Zaragoza, Lozano Blesa Univ Hosp, Fac Med, Dept Obstet & Gynecol, E-50009 Zaragoza, Spain.
   [Genazzani, Andrea R.; Simoncini, Tommaso] Univ Pisa, Div Obstet & Gynecol, Dept Reprod Med & Child Dev, Mol & Cellular Gynecol Endocrinol Lab, I-56100 Pisa, Italy.
C3 Lozano Blesa University Clinical Hospital; University of Zaragoza;
   University of Pisa
RP Chedraui, P (corresponding author), Univ Catolica Santiago Guayaquil, Fac Ciencias Med, Inst Biomed, POB 09-01-4671, Guayaquil, Ecuador.
EM peter.chedraui@cu.ucsg.edu.ec
RI Simoncini, Tommaso/AAC-1879-2019; Blümel, Juan Enrique/JUV-6950-2023
OI Simoncini, Tommaso/0000-0002-2971-0079; Perez-Lopez, Faustino
   R./0000-0002-2801-416X; Escobar Valdivieso, Gustavo
   Saul/0000-0003-1690-3936; Jaramillo, Winston/0000-0001-7547-214X
FU Universidad Catolica de Santiago de Guayaquil, Ecuador [SIU-3373-2011]
FX This research has been supported by the Universidad Catolica de Santiago
   de Guayaquil, Ecuador, through grant No. SIU-3373-2011 (The Omega
   Women's Health Project 2011) provided by the Sistema de Investigacion y
   Desarrollo.
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NR 46
TC 23
Z9 24
U1 0
U2 19
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0378-5122
EI 1873-4111
J9 MATURITAS
JI Maturitas
PD FEB
PY 2013
VL 74
IS 2
BP 154
EP 159
DI 10.1016/j.maturitas.2012.10.017
PG 6
WC Geriatrics & Gerontology; Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology; Obstetrics & Gynecology
GA 083DY
UT WOS:000314444100009
PM 23176759
DA 2025-06-11
ER

PT J
AU Caceres, BA
   Wardecker, BM
   Anderson, J
   Hughes, TL
AF Caceres, Billy A.
   Wardecker, Britney M.
   Anderson, Jocelyn
   Hughes, Tonda L.
TI Revictimization Is Associated With Higher Cardiometabolic Risk in Sexual
   Minority Women
SO WOMENS HEALTH ISSUES
LA English
DT Article
ID ADVERSE CHILDHOOD EXPERIENCES; INTIMATE PARTNER VIOLENCE; MENTAL-HEALTH;
   CARDIOVASCULAR-DISEASE; MULTIDIMENSIONAL SCALE; COMMUNITY SAMPLE;
   NATIONAL SAMPLE; PHYSICAL ABUSE; NURSES HEALTH; VICTIMIZATION
AB Objectives: Although there is evidence that interpersonal trauma is associated with cardiometabolic risk in women, previous studies have not assessed the potential role of revictimization (victimization in both childhood and adulthood) among sexual minority women. Methods: We used data from the Chicago Health and Life Experiences of Women study to examine the associations of revictimization (including physical, sexual, and any revictimization) with self-reported psychosocial factors, health behaviors, and cardiometabolic risk factors (e.g., obesity, hypertension, and diabetes). We tested multiple logistic regression models, adjusted for covariates, to estimate odds ratios of the associations between revictimization and cardiometabolic risk. Results: The sample included 615 sexual minority women with a mean age of 40.0 years; 38.7% White. Eighty-three (13.5%) and 101 (16.4%) participants reported experiencing sexual revictimization and physical revictimization, respectively. Each form of revictimization was associated with higher odds of reporting lifetime depression and recent binge eating, but lower odds of having high social support. Physical revictimization was associated with higher odds of obesity (adjusted odds ratio [AOR], 2.38; 95% confidence interval [CI], 1.38-4.10) and hypertension (AOR, 3.31; 95% CI, 1.70-6.46). Similarly, participants who reported any revictimization were more likely to have obesity (AOR, 2.36; 95% CI, 1.42-3.92) and hypertension (AOR, 2.60; 95% CI, 1.31-5.26). No form of revictimization was associated with a higher odds of diabetes. Conclusions: The higher odds of obesity and hypertension observed among sexual minority women who reported revictimization reinforce the need for early interventions to reduce cardiometabolic risk in this vulnerable population. (c) 2021 Jacobs Institute of Women's Health. Published by Elsevier Inc.
C1 [Caceres, Billy A.; Hughes, Tonda L.] Columbia Univ, Program Study LGBT Hlth, Sch Nursing, 617 West 168th St,Room 239, New York, NY 10032 USA.
   [Wardecker, Britney M.; Anderson, Jocelyn] Penn State Coll Nursing, University Pk, PA USA.
C3 Columbia University; Pennsylvania Commonwealth System of Higher
   Education (PCSHE); Pennsylvania State University; Pennsylvania State
   University - University Park; Penn State Health
RP Caceres, BA (corresponding author), Columbia Univ, Program Study LGBT Hlth, Sch Nursing, 617 West 168th St,Room 239, New York, NY 10032 USA.
EM bac2134@cumc.columbia.edu
RI Anderson, Jocelyn/NIU-1427-2025
OI Anderson, Jocelyn/0000-0003-0572-8378
FU National Institute on Alcohol Abuse and Alcoholism, United States
   [R01AA013328, K23AA027288]; National Heart, Lung, and Blood Institute,
   United States [K01HL146965]
FX Supported by the National Institute on Alcohol Abuse and Alcoholism,
   United States under award numbers R01AA013328 to Dr. Hughes and
   K23AA027288 to Dr. Anderson. Dr. Caceres was supported by an award from
   the National Heart, Lung, and Blood Institute, United States
   (K01HL146965).
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NR 89
TC 8
Z9 10
U1 0
U2 2
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1049-3867
EI 1878-4321
J9 WOMEN HEALTH ISS
JI Womens Health Iss.
PD JUL-AUG
PY 2021
VL 31
IS 4
BP 341
EP 352
DI 10.1016/j.whi.2021.02.004
EA JUN 2021
PG 12
WC Public, Environmental & Occupational Health; Women's Studies
WE Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; Women's Studies
GA TG7AH
UT WOS:000671552500008
PM 33766475
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Aung, TT
   Wah, W
   Chakraborti, A
   Garg, V
AF Aung, The The
   Wah, Win
   Chakraborti, Arnob
   Garg, Vikas
TI Subclinical hypothyroidism and metabolic syndrome in psychiatric
   patients: A systematic literature review and meta-analysis
SO AUSTRALASIAN PSYCHIATRY
LA English
DT Review
DE subclinical hypothyroidism; metabolic syndrome; psychiatric disorders;
   systematic review; meta-analysis
ID BIPOLAR DISORDER; THYROID-DYSFUNCTION; RISK; DEPRESSION; COMPONENTS;
   HORMONE
AB ObjectiveThe systematic review evaluated the association of subclinical hypothyroidism (SCH) with metabolic syndrome (MetS) and specific MetS components in people with major psychiatric disorders.MethodsA systematic review and meta-analysis was conducted to evaluate the association of SCH with MetS and its components in people with major psychiatric conditions.ResultsFive studies incorporating 24,158 participants met the inclusion criteria. All five studies comprised patients with depression and/or anxiety. Three studies incorporating 3365 participants were suitable for the meta-analysis. The pooled Odds Ratio (OR) of MetS was 3.46 (95% Confidence Interval/CI = 1.39-8.62) in major depressive disorder (MDD) and anxiety disorders patients with concurrent SCH compared to those without SCH. Meta-analysis showed a significant positive association between SCH and high body mass index (OR = 2.58, 95%CI = 1.33-5.01), high fasting plasma glucose (OR = 3.05, 95%CI = 1.79-5.18) and low high-density lipoprotein cholesterol (OR = 2.30, 95%CI = 1.82-2.92).ConclusionsThese findings suggest a significant positive association between MetS and SCH in people with MDD and anxiety disorders. This review informed the clinical implications of MetS in MDD with comorbid SCH and the importance of early diagnosis and treatment for SCH and MetS in psychiatric patients.
C1 [Aung, The The] Launceston Gen Hosp, Launceston, Tas, Australia.
   [Wah, Win] Monash Univ, Sch Publ Hlth & Prevent Med, Melbourne, Vic, Australia.
   [Chakraborti, Arnob] Royal Hobart Hosp, Tasmanian Mental Hlth Serv, Hobart, Tas, Australia.
   [Garg, Vikas] Darling Downs Hosp & Hlth Serv, Acute Mental Hlth Unit, Toowoomba, Qld, Australia.
   [Garg, Vikas] Univ Queensland, Rural Clin Sch, Toowoomba, Qld, Australia.
   [Garg, Vikas] Griffith Univ, Sch Med & Dent, Gold Coast Campus, Southport, Qld, Australia.
C3 Launceston General Hospital; Monash University; Royal Hobart Hospital;
   University of Queensland; Griffith University; Griffith University -
   Gold Coast Campus
RP Aung, TT (corresponding author), Launceston Gen Hosp, Tasmanian Mental Hlth Serv, Launceston, Tas 7250, Australia.
RI ; Garg, Vikas/E-8263-2016
OI Wah, Win/0000-0002-4242-5651; Garg, Vikas/0000-0001-6886-3003
FU Project of the RANZCP (Royal Australian and New Zealand College of
   Psychiatrists) Fellowship Program
FX This research project was conducted as the scholarly project of the
   RANZCP (Royal Australian and New Zealand College of Psychiatrists)
   Fellowship Program
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NR 30
TC 1
Z9 1
U1 0
U2 0
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1039-8562
EI 1440-1665
J9 AUSTRALAS PSYCHIATRY
JI Australas. Psychiatry
PD OCT
PY 2024
VL 32
IS 5
BP 470
EP 476
DI 10.1177/10398562241267149
PG 7
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA M0F6Y
UT WOS:001354393500004
PM 39046130
DA 2025-06-11
ER

PT J
AU Goldbacher, EM
   Bromberger, J
   Matthews, KA
AF Goldbacher, Edie M.
   Bromberger, Joyce
   Matthews, Karen A.
TI Lifetime History of Major Depression Predicts the Development of the
   Metabolic Syndrome in Middle-Aged Women
SO PSYCHOSOMATIC MEDICINE
LA English
DT Article
DE metabolic syndrome; depression; women; menopause; alcohol
ID PHYSICAL-ACTIVITY; DRINKING PATTERN; NATIONAL-HEART; HEALTHY WOMEN;
   YOUNG-ADULTS; RISK-FACTOR; PREVALENCE; DISEASE; ASSOCIATION; SYMPTOMS
AB Objective: To prospectively examine the association of major depression with incidence of the metabolic syndrome in women. Methods: Data were drawn from one of seven sites of the Study of Women's Health Across the Nation (SWAN), a prospective cohort study of the menopausal transition. Participants were 429 (34.5% African-American) women. Major depression and comorbid diagnoses were assessed via the Structured Clinical Interview for the Diagnostic and Statistical Manual of Mental Disorders, 4th Edition Axis I Disorders at baseline and seven annual follow-up evaluations. The metabolic syndrome was measured at baseline and each follow-up evaluation (except the second) based on National Cholesterol Education Program (NCEP) criteria. Results: Longitudinal generalized estimating equations (GEE) models indicated that, in women who were free of the metabolic syndrome at baseline, a lifetime major depression history or current major depressive episode at baseline was significantly associated with the onset and presence of the metabolic syndrome during the follow-up (odds ratio=1.82; 95% Confidence Interval (CI)=1.06-3.14). Survival analyses showed that, in women who were free of the metabolic syndrome at baseline, a lifetime major depression history or current major depressive episode at baseline predicted increased risk of developing the metabolic syndrome during the follow-up (hazard ratio=1.66; 95% CI=0.99-3.75). Lifetime history of alcohol abuse or dependence predicted incident metabolic syndrome and attenuated the association between depression and the metabolic syndrome in both models. Conclusions: This study documents that major depression is a significant predictor of the onset of the metabolic syndrome. Intervention studies targeting depression may prevent the development of the metabolic syndrome in women.
C1 [Goldbacher, Edie M.] Temple Univ, Ctr Obes Res & Educ, Philadelphia, PA 19140 USA.
   [Bromberger, Joyce; Matthews, Karen A.] Univ Pittsburgh, Dept Epidemiol, Pittsburgh, PA 15261 USA.
   [Matthews, Karen A.] Univ Pittsburgh, Dept Psychiat & Psychol, Pittsburgh, PA 15261 USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE); Temple
   University; Pennsylvania Commonwealth System of Higher Education
   (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of
   Higher Education (PCSHE); University of Pittsburgh
RP Goldbacher, EM (corresponding author), Temple Univ, Ctr Obes Res & Educ, 3223 N Broad St,Suite 175, Philadelphia, PA 19140 USA.
EM ediemg@temple.edu
RI Stefanadis, Christodoulos/ABH-2232-2020
OI Stefanadis, Christodoulos/0000-0001-5974-6454; bromberger,
   joyce/0000-0001-7101-3800
FU National Institutes of Health (NIH); Department of Health and Human
   Services (DHHS); National Institute on Aging (NIA); National Institute
   of Nursing Research (NINR); NIH Office of Research on Women's Health
   (ORWH) [NR004061, AG012505, AG012535, AG012531, AG012539, AG012546,
   AG012553, AG012554, AG012495]
FX The Study of Women's Health Across the Nation (SWAN) has grant support
   from the National Institutes of Health (NIH), Department of Health and
   Human Services (DHHS), through the National Institute on Aging (NIA),
   the National Institute of Nursing Research (NINR) and the NIH Office of
   Research on Women's Health (ORWH) (Grants NR004061, AG012505, AG012535,
   AG012531, AG012539, AG012546, AG012553, AG012554, and AG012495). The
   content of this paper is solely the responsibility of the authors and
   does not necessarily represent the official views of the NIA, NINR,
   ORWH, or the NIH.
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NR 51
TC 123
Z9 134
U1 0
U2 8
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0033-3174
EI 1534-7796
J9 PSYCHOSOM MED
JI Psychosom. Med.
PD APR
PY 2009
VL 71
IS 3
BP 266
EP 272
DI 10.1097/PSY.0b013e318197a4d5
PG 7
WC Psychiatry; Psychology; Psychology, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry; Psychology
GA 434NQ
UT WOS:000265281800003
PM 19188528
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Teasdale, SB
   Burrows, TL
   Hayes, T
   Hsia, CY
   Watkins, A
   Curtis, J
   Ward, PB
AF Teasdale, Scott B.
   Burrows, Tracy L.
   Hayes, Tegan
   Hsia, Cin Y.
   Watkins, Andrew
   Curtis, Jackie
   Ward, Philip B.
TI Dietary intake, food addiction and nutrition knowledge in young people
   with mental illness
SO NUTRITION & DIETETICS
LA English
DT Article
DE depression; diet; food addiction; mental illness; nutrition; psychosis
ID FREQUENCY QUESTIONNAIRE; PSYCHOTIC DISORDERS; METABOLIC SYNDROME;
   VALIDATION; SCHIZOPHRENIA; INTERVENTIONS; VALIDITY; VERSION; HEALTH;
   RISK
AB Aim The aim of this study was to comprehensively assess dietary intake, nutrition knowledge and food addiction in young people with mental illness.
   Methods This was a three-arm cross-sectional study of 16-25-year-olds attending community mental health services who met criteria for: (i) first-episode psychosis (FEP), (ii) ultra-high risk for psychosis (UHR) or (iii) depression/anxiety. Participants self-completed three validated questionnaires: (i) Australian Eating Survey, (ii) General Nutrition Knowledge Questionnaire-Revised and (iii) Yale Food Addiction Score Questionnaire.
   Results Thirty participants (mean age 19.7 +/- 2.5 years) completed the study (10 per study arm); 43% of the energy intake was obtained from energy-dense, non-nutritious foods, higher than the recommended upper limit (<15%) and the levels reported in the general population (35%). Mean diet quality score was 33.5 +/- 11.8 of 73. Mean food addiction symptom score was 3.3 +/- 3.7. Prevalence of food addiction was 37%. Nutrition knowledge was lower in the FEP and UHR participants than the depression/anxiety group (48.2 +/- 13.8 and 49.5 +/- 8.2 of 88 respectively); however, this difference was not statistically significant.
   Conclusions Unhealthy dietary intake was observed in the early stages of mental illness, likely seeding future poor physical health. Further research is needed on the role of food addiction in this population, including effective intervention techniques.
C1 [Teasdale, Scott B.; Watkins, Andrew; Curtis, Jackie] South Eastern Sydney Local Hlth Dist, Keeping Body Mind Program, Sydney, NSW, Australia.
   [Teasdale, Scott B.; Curtis, Jackie; Ward, Philip B.] Univ New South Wales, Sch Psychiat, Sydney, NSW, Australia.
   [Hayes, Tegan; Hsia, Cin Y.] Univ Sydney, Dept Nutr & Dietet, Sydney, NSW, Australia.
   [Watkins, Andrew] Univ Technol Sydney, Fac Hlth, Sydney, NSW, Australia.
   [Ward, Philip B.] Liverpool Hosp, South Western Sydney Local Hlth Dist, Ingham Inst Appl Med Res, Schizophrenia Res Unit, Sydney, NSW, Australia.
   [Burrows, Tracy L.] Univ Newcastle, Sch Hlth Sci, Newcastle, NSW, Australia.
   [Burrows, Tracy L.] Univ Newcastle, Prior Res Ctr Phys Act & Nutr, Newcastle, NSW, Australia.
C3 South Eastern Sydney Local Health District; University of New South
   Wales Sydney; University of Sydney; University of Technology Sydney;
   Liverpool Hospital; Ingham Institute for Applied Medical Research; South
   Western Sydney Local Health District; University of Newcastle;
   University of Newcastle
RP Teasdale, SB (corresponding author), Keeping Body Mind Program, 26 Llandaff St, Sydney, NSW 2022, Australia.
EM scottbteasdale@gmail.com
RI Curtis, Jackie/J-5789-2019; Teasdale, Scott/AFP-0676-2022; Ward,
   Philip/JCE-6293-2023; Burrows, Tracy/G-7802-2013
OI Ward, Philip/0000-0002-5779-7722; Watkins, Andrew/0000-0003-3452-8682;
   Curtis, Jackie/0000-0001-6884-0098; Teasdale, Scott/0000-0001-6769-8421;
   Burrows, Tracy/0000-0002-1431-7864
CR Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
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NR 30
TC 25
Z9 26
U1 1
U2 26
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1446-6368
EI 1747-0080
J9 NUTR DIET
JI Nutr. Diet.
PD JUL
PY 2020
VL 77
IS 3
BP 315
EP 322
DI 10.1111/1747-0080.12550
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA LS8BM
UT WOS:000536606100004
PM 31243895
DA 2025-06-11
ER

PT J
AU Dallongeville, J
   Cottel, D
   Ferrières, J
   Arveiler, D
   Bingham, A
   Ruidavets, JB
   Haas, B
   Ducimetière, P
   Amouyel, P
AF Dallongeville, J
   Cottel, D
   Ferrières, J
   Arveiler, D
   Bingham, A
   Ruidavets, JB
   Haas, B
   Ducimetière, P
   Amouyel, P
TI Household income is associated with the risk of metabolic syndrome in a
   sex-specific manner
SO DIABETES CARE
LA English
DT Article
ID ACUTE PSYCHOLOGICAL STRESS; SOCIOECONOMIC-STATUS; INSULIN-RESISTANCE;
   PHYSICAL-ACTIVITY; NUTRITION KNOWLEDGE; HEALTH; OBESITY; COMPONENTS;
   MORTALITY; FEATURES
AB OBJECTIVE - To assess the relationship between household income and metabolic syndrome in men and women. 695 men and 1,664 women.
   RESEARCH DESIGN AND METHODS - A total of 1,695 women aged 35-64 years, from three distinct geographical areas of France were investigated. Waist girth, plasma triglycerides, HDL cholesterol, glucose, and systolic blood pressure were used to define Metabolic syndrome according to the National Cholesterol Education Program (NCEP)/ Adult Treatment Panel III (ATPIII) guidelines. Household income, educational level, occupational category, working status, consumption of psychotropic drugs, accommodation status, household composition, physical activity at work and during leisure, alcohol consumption, and smoking habits were recorded with a standardized questionnaire.
   RESULTS - There were 390 (23.0%) men and 381 (16.9%) women who satisfied NCEP/ATPIII criteria for metabolic syndrome. Household income (P < 0.0001) and consumption of psychotropic drugs (P = 0.0005) were associated with metabolic syndrome in women but not in men. In contrast, educational level, occupational category, working status, and accomodation status were associated with Metabolic syndrome in both men and women. After adjustment on lifestyle variables, household income (interaction P < 0.004) remained inversely associated with metabolic syndrome in women but not in men.
   CONCLUSIONS - These data suggest that limited household income, which reflects a complex unfavorable social and economic environment, may increase the risk of metabolic syndrome in a sex-specific manner.
   Diabetes Care 28:409-415. 2005.
C1 Inst Pasteur, INSERM, U508, F-59019 Lille, France.
   Fac Med Purpan, INSERM, Toulouse, France.
   Lab Epidemiol & Sante Publ, Strasbourg, France.
   Hop Paul Brousse, INSERM, Villejuif, France.
   Univ Lille 2, Fac Med, F-59800 Lille, France.
C3 Institut National de la Sante et de la Recherche Medicale (Inserm);
   Pasteur Network; Universite de Lille; Institut Pasteur Lille; Universite
   de Toulouse; Universite Toulouse III - Paul Sabatier; Institut National
   de la Sante et de la Recherche Medicale (Inserm); Assistance Publique
   Hopitaux Paris (APHP); Hopital Universitaire Paul-Brousse - APHP;
   Institut National de la Sante et de la Recherche Medicale (Inserm);
   Universite de Lille
RP Inst Pasteur, INSERM, U508, 1 Rue Pr Calmette, F-59019 Lille, France.
EM jean.dallongeville@pasteur-lille.fr
RI Amouyel, Philippe/D-3662-2018; Ferrieres, Jean/S-7993-2016
OI Ferrieres, Jean/0000-0001-6144-1297; Amouyel,
   Philippe/0000-0001-9088-234X
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NR 37
TC 130
Z9 143
U1 1
U2 5
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0149-5992
EI 1935-5548
J9 DIABETES CARE
JI Diabetes Care
PD FEB
PY 2005
VL 28
IS 2
BP 409
EP 415
DI 10.2337/diacare.28.2.409
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 891WY
UT WOS:000226612900029
PM 15677801
OA Bronze
DA 2025-06-11
ER

PT J
AU Li, A
   Zhou, Q
   Mei, YY
   Zhao, JX
   Zhao, MD
   Xu, J
   Ge, XY
   Xu, Q
AF Li, Ang
   Zhou, Quan
   Mei, Yayuan
   Zhao, Jiaxin
   Zhao, Meiduo
   Xu, Jing
   Ge, Xiaoyu
   Xu, Qun
TI Novel Strategies for Assessing Associations Between Selenium Biomarkers
   and Cardiometabolic Risk Factors: Concentration, Visit-to-Visit
   Variability, or Individual Mean? Evidence From a Repeated-Measures Study
   of Older Adults With High Selenium
SO FRONTIERS IN NUTRITION
LA English
DT Article
DE concentration; visit-to-visit variability (VVV); individual mean (IM);
   cardiometabolic risk factors; selenium
ID SERUM SELENIUM; METABOLIC SYNDROME; BLOOD-PRESSURE; ENVIRONMENTAL
   EXPOSURE; CARDIOVASCULAR EVENTS; WAIST CIRCUMFERENCE; OXIDATIVE STRESS;
   LIPID-METABOLISM; HYPERTENSION; CREATININE
AB Background and AimsPrevious studies have focused only on the cardiometabolic effects of selenium concentrations. We explored whether selenium levels and their visit-to-visit variability (VVV) and individual mean (IM) are independently associated with cardiometabolic risk factors. MethodsA three-wave repeated-measures study of older adults with high selenium (n = 201) was conducted in Beijing from 2016 to 2018. Whole blood selenium and urinary selenium concentrations were measured. VVV and IM were used to profile the homeostasis of the selenium biomarkers. Four indicators, namely standard deviation, coefficient of variation, average real variability, and variability independent of the mean, were employed to characterize VVV. We considered 13 cardiometabolic factors: four lipid profile indicators, three blood pressure indices, glucose, uric acid, waistline, hipline, waist-hip ratio, and sex-specific metabolic syndrome score. Linear mixed-effects regression models with random intercepts for the participants were employed to explore the associations of the selenium concentrations, VVV, and IM with the cardiometabolic factors. ResultsThe geometric mean whole blood and urinary selenium levels were 134.30 and 18.00 mu g/L, respectively. Selenium concentrations were significantly associated with numerous cardiometabolic factors. Specifically, whole blood selenium was positively associated with total cholesterol [0.22, 95% confidence interval (CI): 0.12, 0.33], low-density lipoprotein cholesterol (LDL-C; 0.28, 95% CI: 0.13, 0.42), glucose (0.22, 95% CI: 0.10, 0.34), and uric acid (0.16, 95% CI: 0.04, 0.28). After adjustment for VVV, the IM of whole blood selenium was positively correlated with total cholesterol (0.002, 95% CI: 0.001, 0.004), triglycerides (0.007, 95% CI: 0.004, 0.011), and LDL-C (0.002, 95% CI: 0.000, 0.004). However, we did not observe any robust associations between the VVV of the selenium biomarkers and cardiometabolic risk factors after adjustment for IM. ConclusionOur findings suggest that selenium concentrations and their IMs are significantly associated with cardiometabolic risk factors among older adults with high selenium. Longer repeated-measures studies among the general population are required to validate our findings and elucidate the relevant underlying mechanisms.
C1 [Li, Ang; Zhou, Quan; Mei, Yayuan; Zhao, Jiaxin; Zhao, Meiduo; Xu, Jing; Ge, Xiaoyu; Xu, Qun] Inst Basic Med Sci Chinese Acad Med Sci, Sch Basic Med Peking Union Med Coll, Dept Epidemiol & Biostat, Beijing, Peoples R China.
   [Li, Ang; Zhou, Quan; Mei, Yayuan; Zhao, Jiaxin; Zhao, Meiduo; Xu, Jing; Ge, Xiaoyu; Xu, Qun] Chinese Acad Med Sci, Peking Union Med Coll, Ctr Environm & Hlth Sci, Beijing, Peoples R China.
C3 Chinese Academy of Medical Sciences - Peking Union Medical College;
   Peking Union Medical College
RP Xu, Q (corresponding author), Inst Basic Med Sci Chinese Acad Med Sci, Sch Basic Med Peking Union Med Coll, Dept Epidemiol & Biostat, Beijing, Peoples R China.; Xu, Q (corresponding author), Chinese Acad Med Sci, Peking Union Med Coll, Ctr Environm & Hlth Sci, Beijing, Peoples R China.
EM xuqun@ibms.cams.cn
RI Xu, Jing/GXN-0678-2022; Zhou, Quan/D-6155-2012
OI Li, Ang/0000-0002-4439-7834
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NR 94
TC 12
Z9 13
U1 0
U2 7
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD MAY 30
PY 2022
VL 9
AR 838613
DI 10.3389/fnut.2022.838613
PG 20
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 2D1FE
UT WOS:000811300900001
PM 35711534
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Lankinen, V
   Fröjd, S
   Marttunen, M
   Kaltiala-Heino, R
AF Lankinen, Vilma
   Frojd, Sari
   Marttunen, Mauri
   Kaltiala-Heino, Riittakerttu
TI Perceived rather than actual overweight is associated with mental health
   problems in adolescence
SO NORDIC JOURNAL OF PSYCHIATRY
LA English
DT Article
DE Overweight; perceived overweight; adolescent; mental health
ID BODY-MASS INDEX; SOCIAL PHOBIA INVENTORY; METABOLIC SYNDROME PHENOTYPE;
   CARDIOVASCULAR RISK-FACTORS; BECK DEPRESSION INVENTORY; LOW SELF-ESTEEM;
   CHILDHOOD OVERWEIGHT; COMMUNITY SAMPLE; SCHOOL-CHILDREN; WEIGHT STATUS
AB Background: Overweight and perceived overweight are common among adolescents. The nature of the relationship between overweight/perceived overweight and mental health problems is still unclear.Aims: The aim of this study was to examine whether actual overweight, perceived overweight or both are associated with internalizing and externalizing disorders among adolescents.Methods: Data were collected by two similar school surveys in all Finnish-speaking secondary schools in Tampere (population 200,000) in the academic years 2002-2003 and 2012-2013. A total of 2775 acceptable responses were received. All the analyses were carried out separately for girls and boys. Mean age of the respondents was 15.6 years.Results: In multivariate analyses perceived overweight, not actual weight, was significantly associated with higher risk of self-reported depression (OR: 4.3, 95% CI: 2.9-6.3, p<.001) and self-reported conduct disorder (OR: 2.3, 95% CI: 1.6-3.3, p<.001) in girls and with higher risk of self-reported depression (OR: 3.26, 95% CI: 1.65-6.4, p=.001) and self-reported social phobia (OR: 2.4, 95% CI: 1.0-5.6, p=.05) in boys.Conclusion: Perceived overweight rather than actual weight status is associated with both internalizing and externalizing mental health problems in adolescents.
C1 [Lankinen, Vilma] Univ Tampere, Fac Med, Tampere, Finland.
   [Frojd, Sari] Univ Tampere, Hlth Sci Unit, Fac Social Sci, Tampere, Finland.
   [Marttunen, Mauri] Natl Inst Hlth & Welf, Dept Hlth, Mental Hlth Unit, Helsinki, Finland.
   [Marttunen, Mauri] Univ Helsinki, Dept Adolescent Psychiat, Helsinki, Finland.
   [Kaltiala-Heino, Riittakerttu] Univ Tampere, Adolescent Psychiat, Fac Med, Tampere, Finland.
C3 Tampere University; Tampere University; Finland National Institute for
   Health & Welfare; University of Helsinki; Tampere University
RP Lankinen, V (corresponding author), Univ Tampere, Fac Med, Tampere, Finland.
EM lankinen.vilma.l@student.uta.fi
RI Fröjd, Sari/AAF-7707-2020; Kaltiala, Riittakerttu/T-9411-2019
OI Lankinen, Vilma/0000-0002-3374-8686; Kaltiala,
   Riittakerttu/0000-0002-2783-3892; Frojd, Sari/0000-0002-6383-9028
FU Pirkanmaa Hospital District Research Grant [9P018]
FX Pirkanmaa Hospital District Research Grant 9P018.
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NR 72
TC 16
Z9 17
U1 0
U2 13
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0803-9488
EI 1502-4725
J9 NORD J PSYCHIAT
JI Nord. J. Psychiatr.
PY 2018
VL 72
IS 2
BP 89
EP 96
DI 10.1080/08039488.2017.1389987
PG 8
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA FS7MI
UT WOS:000419981300003
PM 29124989
DA 2025-06-11
ER

PT J
AU Migueles, JH
   Cadenas-Sanchez, C
   Lubans, DR
   Henriksson, P
   Torres-Lopez, LV
   Rodriguez-Ayllon, M
   Plaza-Florido, A
   Gil-Cosano, JJ
   Henriksson, H
   Escolano-Margarit, MV
   Gómez-Vida, J
   Maldonado, J
   Lof, M
   Ruiz, JR
   Labayen, I
   Ortega, FB
AF Migueles, Jairo H.
   Cadenas-Sanchez, Cristina
   Lubans, David R.
   Henriksson, Pontus
   Torres-Lopez, Lucia V.
   Rodriguez-Ayllon, Maria
   Plaza-Florido, Abel
   Gil-Cosano, Jose J.
   Henriksson, Hanna
   Escolano-Margarit, Maria Victoria
   Gomez-Vida, Jose
   Maldonado, Jose
   Lof, Marie
   Ruiz, Jonatan R.
   Labayen, Idoia
   Ortega, Francisco B.
TI Effects of an Exercise Program on Cardiometabolic and Mental Health in
   Children With Overweight or Obesity A Secondary Analysis of a Randomized
   Clinical Trial
SO JAMA NETWORK OPEN
LA English
DT Article
ID PHYSICAL-ACTIVITY; CHILDHOOD OBESITY; PEDIATRIC OBESITY; RISK;
   ADOLESCENTS; YOUTH; DEPRESSION; OUTCOMES; SCALE; LIFE
AB Importance Childhood obesity is a risk factor associated with type 2 diabetes, cardiovascular disease, and mental disorders later in life. Investigation of the parallel effects of a defined exercise program on cardiometabolic and mental health in children with overweight or obesity may provide new insights on the potential benefits of exercise on overall health.
   Objective To investigate the effects of a 20-week exercise program on cardiometabolic and mental health in children with overweight or obesity.
   Design, Setting, and Participants This secondary analysis of a parallel-group randomized clinical trial was conducted in Granada, Spain, from November 1, 2014, to June 30, 2016. Data analyses were performed between February 1, 2020, and July 14, 2022. Children with overweight or obesity aged 8 to 11 years were eligible, and the study was performed in an out-of-school context.
   Intervention The exercise program included 3 to 5 sessions/wk (90 min/session) of aerobic plus resistance training for 20 weeks. The wait-list control group continued with their usual routines.
   Main Outcomes and Measures Cardiometabolic outcomes as specified in the trial protocol included body composition (fat mass, fat-free mass, and visceral adipose tissue), physical fitness (cardiorespiratory, speed-agility, and muscular), and traditional risk factors (waist circumference, blood lipid levels, glucose levels, insulin levels, and blood pressure). Cardiometabolic risk score (z score) was calculated based on age and sex reference values for levels of triglycerides, inverted high-density lipoprotein cholesterol, and glucose, the mean of systolic and diastolic blood pressure, and waist circumference. An additional cardiometabolic risk score also included cardiorespiratory fitness. Mental health outcomes included an array of psychological well-being and ill-being indicators.
   Results The 92 participants included in the per-protocol analyses (36 girls [39%] and 56 boys [61%]) had a mean (SD) age of 10.0 (1.1) years. The exercise program reduced the cardiometabolic risk score byapproximately0.38 (95% CI, -0.74 to -0.02) SDs; decreased low-density lipoprotein cholesterol level by -7.00 (95% CI, -14.27 to 0.37) mg/dL (to convert to mmol/L, multiply by 0.0259), body mass index (calculated as weight in kilograms divided by height in meters squared) by -0.59 (95% CI, -1.06 to -0.12), fat mass index by -0.67 (95% CI, -1.01 to -0.33), and visceral adipose tissue by -31.44 (95% CI, -58.99 to -3.90) g; and improved cardiorespiratory fitness by 2.75 (95% CI, 0.22-5.28) laps in the exercise group compared with the control group. No effects were observed on mental health outcomes.
   Conclusions and Relevance In this secondary analysis of a randomized clinical trial, an aerobic plus resistance exercise program improved cardiometabolic health in children with overweight or obesity but had no effect on mental health.
C1 [Migueles, Jairo H.; Cadenas-Sanchez, Cristina; Torres-Lopez, Lucia V.; Rodriguez-Ayllon, Maria; Plaza-Florido, Abel; Gil-Cosano, Jose J.; Ruiz, Jonatan R.; Ortega, Francisco B.] Univ Granada, Sport & Hlth Univ Res Inst, Fac Sport Sci, Dept Phys Educ & Sports, Granada, Spain.
   [Migueles, Jairo H.; Lof, Marie; Ortega, Francisco B.] Karolinska Inst, Dept Biosci & Nutr, Stockholm, Sweden.
   [Cadenas-Sanchez, Cristina; Ruiz, Jonatan R.; Labayen, Idoia; Ortega, Francisco B.] Inst Salud Carlos III, CIBER Ctr Invest Biomed Red Fisiopatol Obesidad &, Granada, Spain.
   [Cadenas-Sanchez, Cristina] Stanford Univ, Dept Cardiol, Stanford, CA USA.
   [Cadenas-Sanchez, Cristina] Palo Alto Hlth Care Syst, Vet Affairs Med Ctr, Palo Alto, CA USA.
   [Lubans, David R.] Univ Newcastle, Hunter Med Res Inst, Ctr Act Living & Learning, Newcastle, Australia.
   [Lubans, David R.; Ortega, Francisco B.] Univ Jyvaskyla, Fac Sport & Hlth Sci, Jyvaskyla, Finland.
   [Henriksson, Pontus; Henriksson, Hanna] Linkoping Univ, Dept Hlth Med & Caring Sci, Linkoping, Sweden.
   [Rodriguez-Ayllon, Maria] Erasmus Univ, Dept Epidemiol, Med Ctr Rotterdam, Rotterdam, Netherlands.
   [Plaza-Florido, Abel] Univ Calif Irvine, Sch Med, Dept Pediat, Pediat Exercise & Genom Res Ctr, Irvine, CA USA.
   [Gil-Cosano, Jose J.] Univ Loyola Andalucia, Dept Commun & Educ, Seville, Spain.
   [Escolano-Margarit, Maria Victoria; Gomez-Vida, Jose] San Cecilio Univ Hosp, Dept Pediatrics, Granada, Spain.
   [Maldonado, Jose] Univ Granada, Sch Med, Dept Pediat, Granada, Spain.
   [Maldonado, Jose; Ruiz, Jonatan R.] Inst Invest Biosanitaria Granada, Granada, Spain.
   [Labayen, Idoia] Univ Publ Navarra, Inst Sustainabil & Food Chain Innovat, Navarra Inst Hlth Res, Dept Hlth Sci, Pamplona, Spain.
C3 University of Granada; Karolinska Institutet; CIBER - Centro de
   Investigacion Biomedica en Red; CIBEROBN; Instituto de Salud Carlos III;
   Stanford University; US Department of Veterans Affairs; Veterans Health
   Administration (VHA); VA Palo Alto Health Care System; University of
   Newcastle; Hunter Medical Research Institute; University of Jyvaskyla;
   Linkoping University; Erasmus University Rotterdam; Erasmus MC;
   University of California System; University of California Irvine;
   Universidad Loyola Andalucia; Hospital Universitario San Cecilio;
   University of Granada; Instituto de Investigacion Biosanitaria IBS
   Granada; Universidad Publica de Navarra; University of Navarra
RP Cadenas-Sanchez, C; Ortega, FB (corresponding author), Univ Granada, Sport & Hlth Univ,Res Inst, Fac Sport Sci, Dept Phys & Sports Educ, Carretera Alfacar S-N, Granada 18071, Spain.
EM cadenas@ugr.es; ortegaf@ugr.es
RI Migueles, Jairo/AAY-2262-2020; Löf, Marie/AAW-3323-2020; LABAYEN,
   IDOIA/C-7661-2009; Ortega, Francisco/B-4002-2010; Rodriguez-Ayllon,
   Maria/AAU-2529-2020; Lubans, David/G-7436-2013; Cadenas-Sanchez,
   Cristina/J-5635-2019; Henriksson, Pontus/AFS-6140-2022; Gil-Cosano, Jose
   J./C-5966-2019; Torres-Lopez, Lucia/AAX-2201-2020; Henriksson,
   Hanna/AAR-4250-2020; Plaza Florido, Abel Adrian/ABB-9064-2020
OI Plaza Florido, Abel Adrian/0000-0002-5374-3129; Torres Lopez, Lucia
   Victoria/0000-0002-0299-987X
FU Spanish Ministry of Economy and Competitiveness [DEP2013-47540,
   DEP2016-79512-R, DEP2017-91544-EXP, RYC-2011-09011]; Fondo Europeo de
   Desarrollo Regional (FEDER); MCIN/AEI [PID2020-120249RB-I00]; European
   Regional Development Fund (FEDER in Spanish) [B-CTS-355-UGR18]; Spanish
   Ministry of Science and Innovation [FJC2018-037925-I]; European Union
   [101028929]; Spanish Ministry of Education, Culture and Sport
   [FPU15/02645]; Swedish Research Council for Health, Working Life and
   Welfare [2012-00036]; Spanish Ministry of Science, Innovation and
   Universities [FPU17/04802]; Ramon Areces Foundation [DEP2017-91544-EXP];
   Alicia Koplowitz Foundation [ALICIAK-2018]; University of Granada; Plan
   Propio de Investigacion 2016, Excellence actions: Units of Excellence,
   Unit of Excellence on Exercise, Nutrition and Health; Junta de
   Andalucia, Consejeria de Conocimiento, Investigacion y Universidades;
   EXERNET Research Network on Exercise and Health in Special Populations
   [DEP2005-00046/ACTI]; Centro de Investigacion Biomedica en Red de
   Fisiopatologia de la Obesidad y Nutricion, Instituto de Salud Carlos
   III, Ministerio de Ciencia e Innovacion [CB22/03/00058]; Union
   Europea-European Regional Development Fund; Marie Curie Actions (MSCA)
   [101028929] Funding Source: Marie Curie Actions (MSCA)
FX This project was supported with grants DEP2013-47540, DEP2016-79512-R,
   DEP2017-91544EXP, and RYC-2011-09011 from the Spanish Ministry of
   Economy and Competitiveness and the Fondo Europeo de Desarrollo Regional
   (FEDER) and by grant PID2020-120249RB-I00 from the MCIN/AEI
   /10.13039/501100011033. Additional funding was obtained from the
   Andalusian Operational Programme supported with grant B-CTS-355-UGR18
   from the European Regional Development Fund (FEDER in Spanish). Dr
   Cardenas-Sanchez is supported by grant FJC2018-037925-I from the Spanish
   Ministry of Science and Innovation and by a grant from the European
   Union's Horizon 2020 research and innovation programme under the Marie
   Sklodowska Curie grant agreement No 101028929. Dr Migueles is supported
   by grant FPU15/02645 from the Spanish Ministry of Education, Culture and
   Sport, and grant 2012-00036 from the Swedish Research Council for
   Health, Working Life and Welfare. Dr Torres-Lopez is supported by grant
   FPU17/04802 from the Spanish Ministry of Science, Innovation and
   Universities. Dr Rodriquez-Ayllon was funded by grant DEP2017-91544-EXP
   from the Ramon Areces Foundation. Additional support was obtained from
   grant ALICIAK-2018 from the Alicia Koplowitz Foundation, University of
   Granada, Plan Propio de Investigacion 2016, Excellence actions: Units of
   Excellence, Unit of Excellence on Exercise, Nutrition and Health, the
   Junta de Andalucia, Consejeria de Conocimiento, Investigacion y
   Universidades; and grant DEP2005-00046/ACTI from the EXERNET Research
   Network on Exercise and Health in Special Populations. This research was
   supported by grant CB22/03/00058 from the Centro de Investigacion
   Biomedica en Red de Fisiopatologia de la Obesidad y Nutricion, Instituto
   de Salud Carlos III, Ministerio de Ciencia e Innovacion and Union
   Europea-European Regional Development Fund.
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NR 71
TC 20
Z9 20
U1 2
U2 32
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 2574-3805
J9 JAMA NETW OPEN
JI JAMA Netw. Open
PD JUL
PY 2023
VL 6
IS 7
AR e2324839
DI 10.1001/jamanetworkopen.2023.24839
PG 16
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA Q7ON7
UT WOS:001059382200001
PM 37498603
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Muhtz, C
   Zyriax, BC
   Klähn, T
   Windler, E
   Otte, C
AF Muhtz, Christoph
   Zyriax, Birgit-Christiane
   Klaehn, Tilman
   Windler, Eberhard
   Otte, Christian
TI Depressive symptoms and metabolic risk: Effects of cortisol and gender
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE Depression; Cortisol; Metabolic syndrome; Stress; Cardiovascular
   disease; Gender; Diabetes
ID CORONARY-HEART-DISEASE; HYPERCORTISOLEMIC DEPRESSION;
   CARDIOVASCULAR-DISEASE; MAJOR DEPRESSION; YOUNG-ADULTS; ASSOCIATION;
   PULSATILITY; DISORDERS; STRESS; HEALTH
AB We examined gender effects and the role of cortisol in the association between depressive symptoms and metabolic risk in the Stress, Atherosclerosis, and ECG Study (STRATEGY). In 215 healthy adults from the general population (n = 107 men, n = 108 women, distributed equally across four age groups, 30-70 years), we assessed depressive symptoms by the Patient Health Questionnaire (PHQ score >10) and measured variables of the metabolic syndrome: high-density lipoprotein (HDL), triglycerides, systolic and diastolic blood pressure, fasting blood glucose and waist circumference. Salivary cortisol was assessed at 08:00, 12:00, 16:00 and 22:00 h.
   Depressive symptoms were not associated with the metabolic syndrome as entity in the total sample or in men and women separately. However, women with depressive symptoms had larger waist circumferences, higher fasting blood glucose, lower HDL-cholesterol, higher diastolic blood pressure, and higher 16:00 and 22:00 h salivary cortisol compared to women without depressive symptoms. These results persisted after adjusting forage, education, smoking, and physical activity. In adjusted regression analyses, inclusion of cortisol attenuated the association between depressive symptoms and waist, fasting glucose, HDL and diastolic blood pressure in women. In men, we did not find an association between depressive symptoms and variables of the metabolic syndrome.
   In women, depressive symptoms are associated with several variables of the metabolic syndrome. Elevated afternoon and evening cortisol appear to partially mediate this association. (C) 2009 Elsevier Ltd. All rights reserved.
C1 [Muhtz, Christoph; Otte, Christian] Univ Hosp Hamburg Eppendorf, Dept Psychiat & Psychotherapy, D-20246 Hamburg, Germany.
   [Zyriax, Birgit-Christiane; Windler, Eberhard] Univ Hosp Hamburg Eppendorf, Div Endocrinol & Metab Ageing, D-20246 Hamburg, Germany.
   [Klaehn, Tilman] Bethesda Hosp Bergedorf, Hamburg, Germany.
C3 University of Hamburg; University Medical Center Hamburg-Eppendorf;
   University of Hamburg; University Medical Center Hamburg-Eppendorf
RP Muhtz, C (corresponding author), Univ Hosp Hamburg Eppendorf, Dept Psychiat & Psychotherapy, Martinistr 52, D-20246 Hamburg, Germany.
EM cmuhtz@uke.uni-hamburg.de
RI Windler, Eberhard/AAN-3249-2020
OI Otte, Christian/0000-0002-4051-997X
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NR 53
TC 53
Z9 62
U1 0
U2 11
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD AUG
PY 2009
VL 34
IS 7
BP 1004
EP 1011
DI 10.1016/j.psyneuen.2009.01.016
PG 8
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA 463ZD
UT WOS:000267471900007
PM 19278789
DA 2025-06-11
ER

PT J
AU Murphy, JA
   Oliver, G
   Ng, CH
   Wain, C
   Magennis, J
   Opie, RS
   Bannatyne, A
   Sarris, J
AF Murphy, Jenifer A.
   Oliver, Georgina
   Ng, Chee H.
   Wain, Clinton
   Magennis, Jennifer
   Opie, Rachelle S.
   Bannatyne, Amy
   Sarris, Jerome
TI Pilot-Testing of "Healthy Body Healthy Mind": An Integrative Lifestyle
   Program for Patients With a Mental Illness and Co-morbid Metabolic
   Syndrome
SO FRONTIERS IN PSYCHIATRY
LA English
DT Article
DE healthy lifestyles; lifestyle medicine; metabolic syndrome; depression;
   program development
ID WEIGHT-LOSS; INTERVENTIONS; METAANALYSIS; CONSUMERS; PEOPLE; CARE
AB Background: Metabolic syndrome and co-morbid physical health conditions are highly prevalent in people with a mental illness. Modifiable lifestyle factors have been targeted to improve health outcomes. Healthy Body Healthy Mind (HBHM) program was developed to provide an integrated evidence-based program incorporating practical diet and exercise instruction; alongside meditation and mindfulness strategies, and comprehensive psychoeducation, to improve the physical and mental health of those with a mental illness.
   Methods: We report on two data points: (1) Qualitative data derived from the first HBHM program (version 1) exploring its utility and acceptance according to patient feedback; (2) Biometric and mental health data collected on the modified and enhanced 12-week HBHM program (version 2) involving a pilot of 10 participants. Mental and physical health outcomes, weight, abdominal circumference, fasting glucose, cholesterol, and triglycerides were measured at program entry and completion.
   Results: Qualitative data from HBHM version 1 provided valuable feedback to redevelop and enhance the program. At the end of the HBHM (version 2) 12-week program, a significant mean weight loss of 2 kg was achieved, p = 0.023. There was also a significant reduction in abdominal circumference (mean = 2.55 cm) and a decrease in BMI of almost one point (mean = 0.96 kg/m(2)), p = 0.046 and p = 0.019, respectively. There were no significant changes in mental health measures or on any other biometrics.
   Conclusion: Pilot data from the HBHM program found significant reductions in weight and abdominal obesity. The HBHM program could benefit from further modifications, and study replication is required using a controlled design in a larger sample.
C1 [Murphy, Jenifer A.; Oliver, Georgina; Ng, Chee H.; Sarris, Jerome] Univ Melbourne, Dept Psychiat, Professorial Unit, Melbourne Clin, Melbourne, Vic, Australia.
   [Ng, Chee H.; Wain, Clinton; Magennis, Jennifer] Melbourne Clin, Melbourne, Vic, Australia.
   [Opie, Rachelle S.] Deakin Univ, Inst Phys Act & Nutr, Sch Exercise & Nutr Sci, Geelong, Vic, Australia.
   [Bannatyne, Amy] Bond Univ, Fac Hlth Sci & Med, Gold Coast, Qld, Australia.
   [Sarris, Jerome] Western Sydney Univ, NICM Hlth Res Inst, Westmead, NSW, Australia.
C3 University of Melbourne; Deakin University; Bond University; Western
   Sydney University
RP Murphy, JA (corresponding author), Univ Melbourne, Dept Psychiat, Professorial Unit, Melbourne Clin, Melbourne, Vic, Australia.
EM j.sarris@westernsydney.edu.au
OI Ng, Chee/0000-0002-3811-2732; Opie, Rachelle/0000-0002-3816-0670;
   Bannatyne, Amy/0000-0002-4573-6199
CR Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
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NR 21
TC 11
Z9 13
U1 0
U2 10
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-0640
J9 FRONT PSYCHIATRY
JI Front. Psychiatry
PD MAR 6
PY 2019
VL 10
AR 91
DI 10.3389/fpsyt.2019.00091
PG 7
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA HN9EF
UT WOS:000460501600001
PM 30894821
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Lindsay, KL
   Buss, C
   Wadhwa, PD
   Entringer, S
AF Lindsay, Karen L.
   Buss, Claudia
   Wadhwa, Pathik D.
   Entringer, Sonja
TI Maternal Stress Potentiates the Effect of an Inflammatory Diet in
   Pregnancy on Maternal Concentrations of Tumor Necrosis Factor Alpha
SO NUTRIENTS
LA English
DT Article
DE dietary inflammatory index; inflammation; pregnancy; prenatal diet;
   prenatal stress; tumor necrosis factor-alpha
ID LOW-GRADE INFLAMMATION; HIGH-FAT MEALS; INSULIN-RESISTANCE; METABOLIC
   SYNDROME; PRENATAL STRESS; TNF-ALPHA; CARDIOVASCULAR-DISEASE;
   DEVELOPMENTAL ORIGINS; ENDOTHELIAL FUNCTION; DEPRESSIVE SYMPTOMS
AB Maternal inflammation during pregnancy is known to adversely impact fetal development, birth outcomes, and offspring physical and mental health. Diet and stress have been identified as important determinants of inflammation, yet their combined effects have not been examined in the context of pregnancy. The aim of this study was to examine the relationship between maternal diet with inflammatory potential and psychological stress, and to determine their interaction effect on concentrations of tumor necrosis factor (TNF)- across pregnancy. We conducted a prospective longitudinal study of n = 202 women with three assessments during pregnancy, which included: ecological momentary assessment (EMA) of maternal stress using the perceived stress scale (PSS) short version; 24-h dietary recalls from which the dietary inflammatory index (DII) was computed; and serum measurements of TNF-. Across pregnancy, higher perceived stress was associated with consumption of a more pro-inflammatory diet (r = 0.137; p < 0.05). In a linear regression model adjusted for covariates, DII was positively associated with TNF- (B = 0.093, p = 0.010). The effect of the pro-inflammatory diet on concentrations of TNF- was more pronounced in women reporting higher levels of stress (B = 0.134, p = 0.018 for DII*PSS interaction). These results highlight the need to consider nutrition and stress concurrently in the context of inflammation during pregnancy.
C1 [Lindsay, Karen L.] Univ Calif Irvine, Dept Pediat, Irvine, CA 92697 USA.
   [Lindsay, Karen L.; Buss, Claudia; Wadhwa, Pathik D.; Entringer, Sonja] Univ Calif Irvine, UC Irvine Dev Hlth & Dis Res Program, Irvine, CA 92697 USA.
   [Buss, Claudia; Entringer, Sonja] Humboldt Univ, Freie Univ Berlin, Charite Univ Med Berlin, Chariteplatz 1, D-10117 Berlin, Germany.
   [Buss, Claudia; Entringer, Sonja] BIH, Inst Med Psychol, Charitepl 1, D-10117 Berlin, Germany.
   [Wadhwa, Pathik D.] Univ Calif Irvine, Dept Psychiat & Human Behav, Irvine, CA 92697 USA.
   [Wadhwa, Pathik D.] Univ Calif Irvine, Dept Obstet & Gynecol, Irvine, CA 92697 USA.
C3 University of California System; University of California Irvine;
   University of California System; University of California Irvine; Berlin
   Institute of Health; Free University of Berlin; Humboldt University of
   Berlin; Charite Universitatsmedizin Berlin; Berlin Institute of Health;
   Free University of Berlin; Humboldt University of Berlin; Charite
   Universitatsmedizin Berlin; University of California System; University
   of California Irvine; University of California System; University of
   California Irvine
RP Entringer, S (corresponding author), Univ Calif Irvine, UC Irvine Dev Hlth & Dis Res Program, Irvine, CA 92697 USA.; Entringer, S (corresponding author), Humboldt Univ, Freie Univ Berlin, Charite Univ Med Berlin, Chariteplatz 1, D-10117 Berlin, Germany.; Entringer, S (corresponding author), BIH, Inst Med Psychol, Charitepl 1, D-10117 Berlin, Germany.
EM kllindsa@uci.edu; claudia.buss@charite.de; pwadhwa@uci.edu;
   sonja.entringer@charite.de
RI Entringer, Sonja/ABB-9405-2020; Lindsay, Karen/J-4383-2019; Buss,
   Claudia/ABC-3687-2020
OI Buss, Claudia/0000-0002-8738-3133; Entringer, Sonja/0000-0002-9926-7076;
   Lindsay, Karen/0000-0002-4481-9363
FU National Center for Advancing Translational Sciences [UL1TR001414]
   Funding Source: NIH RePORTER
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NR 110
TC 22
Z9 28
U1 0
U2 10
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD SEP
PY 2018
VL 10
IS 9
AR 1252
DI 10.3390/nu10091252
PG 17
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nutrition & Dietetics
GA GY5YI
UT WOS:000448659900125
PM 30200631
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Robinson, LJ
   Law, JM
   Symonds, ME
   Budge, H
AF Robinson, Lindsay J.
   Law, James M.
   Symonds, Michael E.
   Budge, Helen
TI Brown adipose tissue activation as measured by infrared thermography by
   mild anticipatory psychological stress in lean healthy females
SO EXPERIMENTAL PHYSIOLOGY
LA English
DT Article
ID UNCOUPLING PROTEIN-1; ADULT HUMANS; SUPRACLAVICULAR REGION;
   ENERGY-EXPENDITURE; COLD-EXPOSURE; THERMOGENESIS; FAT; HYPERTHERMIA;
   TEMPERATURE; ADIPOCYTES
AB New Findings
   What is the central question of this study? Does psychological stress, which is known to promote cortisol secretion, simultaneously activate brown adipose tissue function in healthy adult females?
   What is the main finding and its importance? One explanation for the pronounced differences in brown adipose tissue function between individuals lies in their responsiveness to psychological stress and, as such, should be taken into account when examining its in vivo stimulation.
   Brown adipose tissue (BAT) has been implicated in the pathogenesis of obesity, type2 diabetes and the metabolic syndrome and is a potential therapeutic target. Brown adipose tissue can have a significant impact on energy balance and glucose homeostasis through the action of uncoupling protein1, dissipating chemical energy as heat following neuroendocrine stimulation. We hypothesized that psychological stress, which is known to promote cortisol secretion, would simultaneously activate BAT at thermoneutrality. Brown adipose tissue activity was measured using infrared thermography to determine changes in the temperature of the skin overlying supraclavicular BAT (T-SCR). A mild psychological stress was induced in five healthy, lean, female, Caucasian volunteers using a short mental arithmetic (MA) test. The T-SCR was compared with a repeated assessment, in which the MA test was replaced with a period of relaxation. Although MA did not elicit an acute stress response, anticipation of MA testing led to an increase in salivary cortisol, indicative of an anticipatory stress response, that was associated with a trend towards higher absolute and relative T-SCR. A positive correlation between T-SCR and cortisol was found during the anticipatory phase, a relationship that was enhanced by increased cortisol linked to MA. Our findings suggest that subtle changes in the level of psychological stress can stimulate BAT, findings that may account for the high variability and inconsistency in reported BAT prevalence and activity measured by other modalities. Consistent assessment of this uniquely metabolic tissue is fundamental to the discovery of potential therapeutic strategies against metabolic disease.
C1 [Robinson, Lindsay J.; Law, James M.; Symonds, Michael E.; Budge, Helen] Univ Nottingham, Univ Nottingham Hosp, Sch Med, Div Child Hlth Obstet & Gynaecol,Early Life Res U, Nottingham NG7 2UH, England.
C3 University of Nottingham
RP Symonds, ME (corresponding author), Univ Nottingham, Univ Nottingham Hosp, Sch Med, Div Child Hlth Obstet & Gynaecol,Early Life Res U, Nottingham NG7 2UH, England.
EM michael.symonds@nottingham.ac.uk
RI Law, James/M-8888-2018
OI Law, James/0000-0002-4923-3193; Symonds, Michael/0000-0001-9649-8963
FU University of Nottingham; Nottingham University Hospitals Charity
FX This work was supported by the University of Nottingham and the
   Nottingham University Hospitals Charity.
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NR 45
TC 36
Z9 40
U1 0
U2 13
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0958-0670
EI 1469-445X
J9 EXP PHYSIOL
JI Exp. Physiol.
PD APR 1
PY 2016
VL 101
IS 4
BP 549
EP 557
DI 10.1113/EP085642
PG 9
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Physiology
GA DI7LF
UT WOS:000373680600012
PM 26855404
OA Bronze
DA 2025-06-11
ER

PT J
AU Limon, VM
   Lee, M
   Gonzalez, B
   Choh, AC
   Czerwinski, SA
AF Limon, Victoria M.
   Lee, Miryoung
   Gonzalez, Brandon
   Choh, Audrey C.
   Czerwinski, Stefan A.
TI The impact of metabolic syndrome on mental health-related quality of
   life and depressive symptoms
SO QUALITY OF LIFE RESEARCH
LA English
DT Article
DE Metabolic syndrome; Depressive symptoms; Mental health; Quality of life
ID ASSOCIATION; QUESTIONNAIRE; PREVALENCE; PHQ-9; MODE; RISK; CARE
AB Purpose Results examining associations between metabolic syndrome (MetS) and depression, as well as on quality of life (QoL), are inconsistent. We aimed to determine whether individuals with MetS had decreased mental health-related QoL (MH-QoL) and higher frequency of depressive symptoms. Methods Data from 1,015 participants from the Fels Longitudinal Study were analyzed (mean age +/- SD: 49.6 +/- 18.7 years, 29.3% MetS, 51% females). MetS was determined using American Heart Association/National Heart, Lung, and Blood Institute criteria. Depressive symptoms (yes vs. no) were assessed with The Patient Health Questionnaire-9 (PHQ-9). MH-QoL (low (<= 42) vs. high) was assessed with The Medical Outcomes 36-Item Short Form Survey (SF-36). Sex- and age-stratified mixed effects logistic regressions were used to examine the longitudinal relationship between MetS and MH-QoL while adjusting for covariates such as age, smoking status, and drinking status. Results In cross-sectional analysis, MetS was significantly associated with elevated depressive symptoms in women (OR 2.14, 95% CI 1.22-3.78, p < 0.01), but not in men. In the longitudinal analysis, MetS was observed to have a protective effect among men in the older age group as it approached significance (OR 0.34, 95% CI 0.11-1.05, p = 0.06). Conclusion MetS was adversely associated with depressive symptoms and poor MH-QoL. Our cross-sectional results suggest that depressive symptoms are higher among women with MetS. Interestingly, our longitudinal results suggest that MH-QoL in men with MetS may improve with age.
C1 [Limon, Victoria M.] Roosevelt Univ, Coll Arts & Sci, 430 S Michigan Ave, Chicago, IL 60605 USA.
   [Lee, Miryoung; Gonzalez, Brandon; Choh, Audrey C.; Czerwinski, Stefan A.] Univ Texas Hlth Sci Ctr Houston, Sch Publ Hlth, Dept Epidemiol Human Genet & Environm Sci, Brownsville, TX USA.
C3 Roosevelt University; University of Texas System; University of Texas
   Health Science Center Houston
RP Limon, VM (corresponding author), Roosevelt Univ, Coll Arts & Sci, 430 S Michigan Ave, Chicago, IL 60605 USA.
EM vlimon@mail.roosevelt.edu
FU National Institutes of Health [HD012252, DK111201]
FX We extend our thanks to the research participants of the Fels
   Longitudinal Study and to all research assistants and staff. This study
   was supported by grants from the National Institutes of Health: HD012252
   and DK111201.
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NR 50
TC 20
Z9 22
U1 0
U2 8
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0962-9343
EI 1573-2649
J9 QUAL LIFE RES
JI Qual. Life Res.
PD AUG
PY 2020
VL 29
IS 8
BP 2063
EP 2072
DI 10.1007/s11136-020-02479-5
EA MAR 2020
PG 10
WC Health Care Sciences & Services; Health Policy & Services; Public,
   Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services; Public, Environmental & Occupational
   Health
GA MK3BX
UT WOS:000521787500001
PM 32215841
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Roohafza, H
   Heidari, D
   Talaei, M
   Nouri, F
   Khani, A
   Sarrafzadegan, N
   Sadeghi, M
AF Roohafza, Hamidreza
   Heidari, Danesh
   Talaei, Mohammad
   Nouri, Fatemeh
   Khani, Azam
   Sarrafzadegan, Nizal
   Sadeghi, Masoumeh
TI Are different perceived stressors associated with metabolic syndrome: a
   longitudinal cohort study of adults in central Iran
SO JOURNAL OF DIABETES AND METABOLIC DISORDERS
LA English
DT Article
DE Metabolic syndrome; Psychological stress; Perceived stress;
   Psychological distress
ID OBESITY; SAMPLE; WORK
AB PurposeThe link between metabolic syndrome (MetS) and various stressors has not been thoroughly investigated. We aimed to examine the relationship between MetS and different perceived stressors.MethodsIn this study, we included participants of the Isfahan Cohort study from three counties in central Iran, with data in the 2007 (n = 3178) and 2013 (n = 1693) follow-up stages. We examined the association between distress and perceived stress domains (including job security, job conflicts, personal conflicts, loss and separation, social relations, and health concerns) and MetS.ResultsMetS was identified in 35.8% of participants in the 2007 cohort and 46.2% in the 2013 cohort. In the fully adjusted analysis, the odds ratio (OR) (95%CI) for MetS according to psychological status was 1.65 (1.64-1.65) for psychological distress level, 1.09 (1.01-1.20) for psychological distress score, and 1.21 (1.09-1.42) for total perceived stress score. There was also evidence of association for social relations, personal conflicts, job conflicts, job security, health concern, loss and separation, educational concerns, and sexual life subscales.ConclusionPerceived stressors and some of their subscales were associated with MetS.
C1 [Roohafza, Hamidreza; Khani, Azam; Sarrafzadegan, Nizal] Isfahan Univ Med Sci, Cardiovasc Res Inst, Isfahan Cardiovasc Res Ctr, Esfahan, Iran.
   [Heidari, Danesh] Isfahan Univ Med Sci, Sch Med, Esfahan, Iran.
   [Talaei, Mohammad] Queen Mary Univ London, Inst Populat Hlth Sci, Barts & London Sch Med, London, England.
   [Nouri, Fatemeh] Isfahan Univ Med Sci, Cardiovasc Res Inst, Intervent Cardiol Res Ctr, Esfahan, Iran.
   [Sadeghi, Masoumeh] Isfahan Univ Med Sci, Cardiovasc Res Inst, Cardiac Rehabil Res Ctr, Esfahan, Iran.
C3 Isfahan University of Medical Sciences; Isfahan University of Medical
   Sciences; University of London; Queen Mary University London; Isfahan
   University of Medical Sciences; Isfahan University of Medical Sciences
RP Sadeghi, M (corresponding author), Isfahan Univ Med Sci, Cardiovasc Res Inst, Cardiac Rehabil Res Ctr, Esfahan, Iran.
EM sadeghimasoumeh@gmail.com
RI Sadeghi, Masoumeh/AAU-8493-2021; Taheri, Majid/V-4415-2019; Nouri,
   Fatemeh/KCY-5479-2024
OI Nouri, Fatemeh/0000-0002-0191-7668; Sadeghi Mahonak,
   Masoumeh/0000-0001-7179-5558
FU We would like to express our special thanks of gratitude to all
   individuals who participated in this study and the ICS staff for their
   kind cooperation. Also, we appreciated the Iranian Budget and Planning
   Organization who funded the baseline of the study [31309304]; Iranian
   Budget and Planning Organization
FX We would like to express our special thanks of gratitude to all
   individuals who participated in this study and the ICS staff for their
   kind cooperation. Also, we appreciated the Iranian Budget and Planning
   Organization who funded the baseline of the study with a grant No.
   31309304.
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NR 42
TC 0
Z9 0
U1 0
U2 1
PU SPRINGER INT PUBL AG
PI CHAM
PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND
EI 2251-6581
J9 J DIABETES METAB DIS
JI J. Diabetes Metab. Disord.
PD DEC
PY 2023
VL 22
IS 2
BP 1715
EP 1721
DI 10.1007/s40200-023-01304-3
EA SEP 2023
PG 7
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA GP6N6
UT WOS:001074833600002
PM 37975076
OA Green Published
DA 2025-06-11
ER

PT J
AU Ali, AT
   Guidozzi, F
AF Ali, A. T.
   Guidozzi, F.
TI Midlife women's health consequences associated with polycystic ovary
   syndrome
SO CLIMACTERIC
LA English
DT Review
DE Polycystic ovary syndrome; metabolic syndrome; obesity; type 2 diabetes;
   depression; cardiovascular disease; endometrial cancer
ID INTIMA-MEDIA THICKNESS; CORONARY-ARTERY CALCIFICATION; IMPAIRED
   GLUCOSE-TOLERANCE; TYPE-2 DIABETES-MELLITUS; METABOLIC SYNDROME;
   CARDIOVASCULAR-DISEASE; OXIDATIVE STRESS; BLOOD-PRESSURE; INCREASED
   RISK; YOUNG-WOMEN
AB Polycystic ovary syndrome (PCOS) is one of the most common female endocrinopathies. Its symptoms may appear as early as adolescence and may include irregular menstrual periods, amenorrhea, hirsutism and obesity. Regardless of their phenotypic appearance, women with PCOS are metabolically obese. PCOS is associated with metabolic syndrome, type 2 diabetes, depression, cardiovascular disease and gynecological cancers. The metabolic disorders in obese women with PCOS are invariably due to insulin resistance, while inflammation, oxidative stress and possible interaction with environmental factors are among the features linking women with PCOS alone to metabolic disorders. The current review aims to highlight the relationship between PCOS and midlife women's health complications.
C1 [Ali, A. T.] Stellenbosch Univ, Tygerberg Hosp, NHLS, Dept Chem Pathol, Cape Town, South Africa.
   [Ali, A. T.] Stellenbosch Univ, Fac Med & Hlth Sci, Cape Town, South Africa.
   [Guidozzi, F.] Univ Witwatersrand, Fac Hlth Sci, Dept Obstet & Gynaecol, Johannesburg, South Africa.
C3 Tygerberg Hospital; Stellenbosch University; Stellenbosch University;
   University of Witwatersrand
RP Ali, AT (corresponding author), Tygerberg Hosp, Dept Pathol, POB 19113, ZA-7505 Cape Town, South Africa.; Ali, AT (corresponding author), Stellenbosch Med Sch, POB 19113, ZA-7505 Cape Town, South Africa.
EM atali@sun.ac.za
OI Ali, Aus/0000-0002-2026-2433
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NR 89
TC 4
Z9 4
U1 0
U2 11
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1369-7137
EI 1473-0804
J9 CLIMACTERIC
JI Climacteric
PD MAR 3
PY 2020
VL 23
IS 2
BP 116
EP 122
DI 10.1080/13697137.2019.1679111
EA OCT 2019
PG 7
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA KI1HZ
UT WOS:000492886200001
PM 31657237
DA 2025-06-11
ER

PT J
AU Schwartz, JA
   Savolainen, J
   Granger, DA
   Calvi, JL
AF Schwartz, Joseph A.
   Savolainen, Jukka
   Granger, Douglas A.
   Calvi, Jessica L.
TI Is Crime Bad for Your Health? The Link Between Delinquent Offending and
   Cardiometabolic Risk
SO CRIME & DELINQUENCY
LA English
DT Article
DE stress; cardiometabolic risk; health; delinquency
ID GENERAL STRAIN THEORY; PERCEIVED DISCRIMINATION; BIOLOGICAL STRESS;
   OXIDATIVE STRESS; ALLOSTATIC LOAD; YOUNG-ADULTS; ADOLESCENTS;
   VICTIMIZATION; EXPERIENCES; FOUNDATION
AB Specific sources of psychophysiological dysfunction have been identified as a primary mechanism of the association between stress and health, wherein chronic and prolonged exposure to stressors results in downstream negative consequences of stress-linked dysregulation that increase the likelihood of chronic health problems. Factors pertinent to criminological inquiry have been previously identified as sources of physiological dysfunction, but the extent to which offending over the life course operates in a similar manner has yet to be examined. The current study examines the longitudinal association between delinquency and physiological dysfunction in cardiovascular and metabolic functioning (i.e., cardiometabolic risk). The results of longitudinal structural equation models revealed that greater levels of delinquency are associated with higher levels of cardiometabolic risk.
C1 [Schwartz, Joseph A.] Univ Nebraska, Sch Criminol & Criminal Justice, 6001 Dodge St,218 CPACS, Omaha, NE 68182 USA.
   [Savolainen, Jukka] Wayne State Univ, Sociol & Criminol, Detroit, MI USA.
   [Granger, Douglas A.] Johns Hopkins Univ, Baltimore, MD USA.
   [Granger, Douglas A.] Univ Calif Irvine, Inst Interdisciplinary Salivary Biosci Res, Irvine, CA USA.
   [Granger, Douglas A.] Univ Calif Irvine, Beall Appl Innovat, Irvine, CA USA.
   [Granger, Douglas A.] Univ Nebraska, Lincoln, NE USA.
   [Calvi, Jessica L.] Univ Nebraska, Salivary Biosci Lab, Lincoln, NE USA.
C3 University of Nebraska System; Wayne State University; Johns Hopkins
   University; University of California System; University of California
   Irvine; University of California System; University of California
   Irvine; University of Nebraska System; University of Nebraska Lincoln;
   University of Nebraska System; University of Nebraska Lincoln
RP Schwartz, JA (corresponding author), Univ Nebraska, Sch Criminol & Criminal Justice, 6001 Dodge St,218 CPACS, Omaha, NE 68182 USA.
EM jaschwartz@unomaha.edu
OI Schwartz, Joseph/0000-0001-5777-0573
FU Eunice Kennedy Shriver National Institute of Child Health and Human
   Development [P01-HD31921]
FX This research uses data from the National Longitudinal Study of
   Adolescent to Adult Health (Add Health), a program project directed by
   Kathleen Mullan Harris and designed by J. Richard Udry, Peter S.
   Bearman, and Kathleen Mullan Harris at the University of North Carolina
   at Chapel Hill, and funded by grant P01-HD31921 from the Eunice Kennedy
   Shriver National Institute of Child Health and Human Development, with
   cooperative funding from 23 other federal agencies and foundations.
   Special acknowledgment is due Ronald R. Rindfuss and Barbara Entwisle
   for assistance in the original design. Information on how to obtain the
   Add Health data files is available on the Add Health website
   (http://www.cpc.unc.edu/addhealth).No direct support was received from
   grant P01-HD31921 for this analysis.
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NR 53
TC 12
Z9 12
U1 0
U2 8
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0011-1287
EI 1552-387X
J9 CRIME DELINQUENCY
JI Crime Delinq.
PD SEP
PY 2020
VL 66
IS 10
SI SI
BP 1347
EP 1368
AR 0011128720903048
DI 10.1177/0011128720903048
EA FEB 2020
PG 22
WC Criminology & Penology
WE Social Science Citation Index (SSCI)
SC Criminology & Penology
GA MM2ET
UT WOS:000513403700001
DA 2025-06-11
ER

PT J
AU Ji, S
   Chen, YJ
   Zhou, YY
   Cao, YT
   Li, X
   Ding, GY
   Tang, F
AF Ji, Shuang
   Chen, Yujiao
   Zhou, Yuying
   Cao, Yiting
   Li, Xiao
   Ding, Guoyong
   Tang, Fang
TI Association between anxiety and metabolic syndrome: An updated
   systematic review and meta-analysis
SO FRONTIERS IN PSYCHIATRY
LA English
DT Review
DE anxiety; metabolic syndrome; cross-sectional study; cohort study;
   meta-analysis
ID RISK-FACTORS; DEPRESSION; HEALTH; PREVALENCE; SYMPTOMS; DISEASE;
   DISORDERS; QUALITY; OBESITY; IMPACT
AB ObjectivePrevious studies have demonstrated an association between anxiety and metabolic syndrome (MetS). However, the association is still controversial. This updated meta-analysis aimed to reanalyze the association between anxiety and MetS. MethodsWe comprehensively searched PubMed, Embase and Web of Science for all related studies published before January 23, 2023. Observational studies that informed effect size with 95% confidence interval (CI) for the association between anxiety and MetS were included. According to heterogeneity between studies, fixed or random effects models were applied to calculate the pooled effect size. Publication bias was examined by funnel plots. ResultsThe research included 24 cross-sectional studies: 20 studies used MetS as the dependent variable with a pooled OR of 1.07 (95% CI: 1.01-1.13) and four studies used anxiety as the dependent variable with a pooled OR of 1.14 (95% CI: 1.07-1.23). Three cohort studies were found: two studies detected the association of baseline anxiety with the risk of MetS, one of the studies demonstrated a significant association, but a similar result was not found in another study; one study showed no significant association between baseline MetS and the risk of anxiety. ConclusionCross-sectional studies indicated an association between anxiety and MetS. The results from cohort studies are still inconsistent and limited. More large-scale prospective studies are needed to further reveal the causal relationship of anxiety with MetS.
C1 [Ji, Shuang; Chen, Yujiao; Zhou, Yuying; Cao, Yiting; Tang, Fang] Weifang Med Univ, Shandong Prov Qianfoshan Hosp, Dept Neurol, Jinan, Peoples R China.
   [Ji, Shuang; Chen, Yujiao; Zhou, Yuying; Cao, Yiting; Tang, Fang] Shandong Inst Neuroimmunol, Jinan, Peoples R China.
   [Li, Xiao] Shandong First Med Univ & Shandong Prov Qianfoshan, Dept Clin Pharm, Affiliated Hosp 1, Jinan, Peoples R China.
   [Li, Xiao] Shandong Univ, Shandong Prov Qianfoshan Hosp, Dept Clin Pharm, Jinan, Peoples R China.
   [Ding, Guoyong] Shandong First Med Univ & Shandong Acad Med Sci, Sch Publ Hlth, Jinan, Peoples R China.
   [Tang, Fang] Shandong First Med Univ, Ctr Big Data Res Hlth & Med, Affiliated Hosp 1, Jinan, Peoples R China.
   [Tang, Fang] Shandong Univ, Shandong Prov Qianfoshan Hosp, Cheeloo Coll Med, Jinan, Peoples R China.
C3 Shandong Second Medical University; Shandong First Medical University &
   Shandong Academy of Medical Sciences; Shandong First Medical University
   & Shandong Academy of Medical Sciences; Shandong University; Shandong
   First Medical University & Shandong Academy of Medical Sciences;
   Shandong First Medical University & Shandong Academy of Medical
   Sciences; Shandong First Medical University & Shandong Academy of
   Medical Sciences; Shandong University
RP Tang, F (corresponding author), Weifang Med Univ, Shandong Prov Qianfoshan Hosp, Dept Neurol, Jinan, Peoples R China.; Tang, F (corresponding author), Shandong Inst Neuroimmunol, Jinan, Peoples R China.; Ding, GY (corresponding author), Shandong First Med Univ & Shandong Acad Med Sci, Sch Publ Hlth, Jinan, Peoples R China.; Tang, F (corresponding author), Shandong First Med Univ, Ctr Big Data Res Hlth & Med, Affiliated Hosp 1, Jinan, Peoples R China.; Tang, F (corresponding author), Shandong Univ, Shandong Prov Qianfoshan Hosp, Cheeloo Coll Med, Jinan, Peoples R China.
EM dgy-153@163.com; tangfangsdu@gmail.com
RI YiTing, Cao/HMO-6039-2023
FU National Natural Science Foundation of China [71804093]; Academic
   Promotion Programme of Shandong First Medical University [2019LJ005,
   2019QL013]; Academic Promotion Programme of School of Public Health,
   Shandong First Medical University [GW202218]
FX This study was supported by the National Natural Science Foundation of
   China (71804093), Academic Promotion Programme of Shandong First Medical
   University (2019LJ005 and 2019QL013), and Academic Promotion Programme
   of School of Public Health, Shandong First Medical University
   (GW202218).
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NR 79
TC 8
Z9 8
U1 2
U2 10
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-0640
J9 FRONT PSYCHIATRY
JI Front. Psychiatry
PD FEB 16
PY 2023
VL 14
AR 1118836
DI 10.3389/fpsyt.2023.1118836
PG 9
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 9M4DQ
UT WOS:000942183000001
PM 36873213
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Mohammadi, MA
   Dabagh, AE
   Hassanizadeh, S
   Askari, G
   Bagherniya, M
   Sahebkar, A
AF Mohammadi, Mohammad Amin
   Dabagh, Ali Ebrahimi
   Hassanizadeh, Shirin
   Askari, Gholamreza
   Bagherniya, Mohammad
   Sahebkar, Amirhossein
TI Effects of berry consumption on cardiometabolic risk factors in patients
   with metabolic syndrome: a systematic review and meta-analysis of
   randomised controlled trials
SO INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION
LA English
DT Review; Early Access
DE Metabolic syndrome; berry; anthropometric; lipid profile; blood
   pressure; inflammation
ID OXIDATIVE STRESS; CRANBERRY JUICE; DOUBLE-BLIND; ANTIOXIDANT CAPACITY;
   ENDOTHELIAL FUNCTION; ADIPOSE-TISSUE; KAPPA-B; INFLAMMATION; EXPRESSION;
   SUPPLEMENTATION
AB The current study explored the effect of berry consumption on metabolic syndrome (MetS) factors. After full screening, 14 trials were selected for final analysis, involving 327 intervention and 284 control subjects with MetS. Berry consumption significantly increased HDL-C (WMD: 1.771 mg/dL, 95% CI: 1.415-2.128) without affecting LDL-C, TC, TG or leptin levels. BMI, waist circumference, systolic and diastolic BP, TNF-alpha, IL-6, CRP, adiponectin, HbA1C, HOMA-IR, glucose and insulin remained unaffected. The subgroup analysis showed that interventions <12 weeks resulted in a significant increase in HDL-C levels and a significant decrease in serum TG levels. On the other hand, reductions in IL-6 and glucose levels were observed in interventions >12 weeks. It was also shown that CRP and HDL-C improvements were seen only in studies that included more than 50 participants. Berry consumption may improve HDL-C, glucose, IL-6 and CRP, supporting its inclusion in dietary strategies for managing MetS.
C1 [Mohammadi, Mohammad Amin; Hassanizadeh, Shirin] Isfahan Univ Med Sci, Student Res Comm, Esfahan, Iran.
   [Mohammadi, Mohammad Amin; Hassanizadeh, Shirin; Askari, Gholamreza; Bagherniya, Mohammad] Isfahan Univ Med Sci, Nutr & Food Secur Res Ctr, Sch Nutr & Food Sci, Esfahan, Iran.
   [Mohammadi, Mohammad Amin; Hassanizadeh, Shirin; Askari, Gholamreza; Bagherniya, Mohammad] Isfahan Univ Med Sci, Sch Nutr & Food Sci, Dept Community Nutr, Esfahan, Iran.
   [Dabagh, Ali Ebrahimi] Mashhad Univ Med Sci, Sch Med, Dept Nutr Sci, Mashhad, Iran.
   [Askari, Gholamreza; Bagherniya, Mohammad] Isfahan Univ Med Sci, Anesthesia & Crit Care Res Ctr, Esfahan, Iran.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Biotechnol Res Ctr, Mashhad, Iran.
   [Sahebkar, Amirhossein] Chitkara Univ, Chitkara Coll Pharm, Ctr Res Impact & Outcome, Rajpura, Punjab, India.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Basic Sci Res Inst, Appl Biomed Res Ctr, Mashhad, Iran.
C3 Isfahan University of Medical Sciences; Isfahan University of Medical
   Sciences; Isfahan University of Medical Sciences; Mashhad University of
   Medical Sciences; Isfahan University of Medical Sciences; Mashhad
   University of Medical Sciences; Chitkara University, Punjab; Mashhad
   University of Medical Sciences
RP Bagherniya, M (corresponding author), Isfahan Univ Med Sci, Nutr & Food Secur Res Ctr, Sch Nutr & Food Sci, Esfahan, Iran.; Bagherniya, M (corresponding author), Isfahan Univ Med Sci, Sch Nutr & Food Sci, Dept Community Nutr, Esfahan, Iran.; Sahebkar, A (corresponding author), Mashhad Univ Med Sci, Pharmaceut Technol Inst, Biotechnol Res Ctr, Mashhad, Iran.
EM bagherniya@yahoo.com; amir_saheb2000@yahoo.com
RI Sahebkar, Amirhossein/B-5124-2018; Askari, Gholamreza/ABE-3527-2020;
   Ebrahimi Dabagh, Ali/GYR-0648-2022
FU Student Research Committee of Isfahan University of Medical Sciences
   [1402242]
FX This study was approved by the Research Ethics Committee of Isfahan
   University of Medical Sciences (IR.MUI.PHANUT. REC.1402.058) and
   supported by the Student Research Committee of Isfahan University of
   Medical Sciences (Grant Number: 1402242).
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NR 80
TC 0
Z9 0
U1 0
U2 0
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0963-7486
EI 1465-3478
J9 INT J FOOD SCI NUTR
JI Int. J. Food Sci. Nutr.
PD 2025 MAY 27
PY 2025
DI 10.1080/09637486.2025.2510358
EA MAY 2025
PG 22
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA 3EW2L
UT WOS:001498672600001
PM 40436036
DA 2025-06-11
ER

PT J
AU Daneshzad, E
   Keshavarz, SA
   Qorbani, M
   Larijani, B
   Azadbakht, L
AF Daneshzad, Elnaz
   Keshavarz, Seyed-Ali
   Qorbani, Mostafa
   Larijani, Bagher
   Azadbakht, Leila
TI Dietary total antioxidant capacity and its association with sleep,
   stress, anxiety, and depression score: A cross-sectional study among
   diabetic women
SO CLINICAL NUTRITION ESPEN
LA English
DT Article
DE Dietary total antioxidant capacity; Sleep; Depression; Diabetic
   patients; Women
ID METABOLIC SYNDROME; DOUBLE-BLIND; FATTY-ACIDS; OXIDATIVE STRESS; PRIMARY
   INSOMNIA; QUALITY INDEX; ADULTS; PREVALENCE; MAGNESIUM; DURATION
AB Background: Diabetes as a common chronic disease leads to several serious disabilities and complications. Patients with type 2 diabetes are involved with psychological and sleep disorders which diet can be effective in the management of these problems. The present study aimed to investigate the association of Dietary Total Antioxidant Capacity (DTAC) and sleep, stress, anxiety, and depression among diabetic women.
   Methods: This cross-sectional study conducted on 265 women with type 2 diabetes. A validated food frequency questionnaire was filled to evaluate dietary intakes. We calculated DTAC based on amounts of antioxidant in each dietary item using the ferric reducing ability of plasma (FRAP) and oxygen radical absorbance capacity (ORAC) databases. Pittsburgh Sleep Quality Index was used to assess sleep quality. Moreover, 21 items Depression, Anxiety, and Stress Scale was used to assess mental disorders.
   Results: Subjects in the highest tertile of FRAP and ORAC score compared to those in the lowest tertile of these scores had 94% and 87% lower risk of poor sleep, respectively. The odds of depression were negatively related to the highest tertile of FRAP and ORAC score (OR: 0.21, 95%CI: 0.09-0.50 and OR: 0.21, 95%CI: 0.10-0.48, respectively). Participants with the highest tertile of FRAP compared to those within the lowest tertile of FRAP score had a 59% lower risk of anxiety. The odds of stress were negatively related to the highest tertile of FRAP and ORAC score (OR: 0.10, 95%CI: 0.04-0.23 and OR: 0.13, 95%CI: 0.06-0.29, respectively).
   Conclusion: There is a significant association between DTAC, sleep status and psychological disorders. However, prospective studies in both genders should be conducted to confirm the actual relationship. (C) 2020 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights reserved.
C1 [Daneshzad, Elnaz; Azadbakht, Leila] Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Community Nutr, POB 1416643931, Tehran, Iran.
   [Keshavarz, Seyed-Ali] Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Clin Nutr, Tehran, Iran.
   [Qorbani, Mostafa] Alborz Univ Med Sci, Noncommunicable Dis Res Ctr, Karaj, Iran.
   [Qorbani, Mostafa] Univ Tehran Med Sci, Chron Dis Res Ctr, Tehran, Iran.
   [Qorbani, Mostafa] Univ Tehran Med Sci, Metab Populat Sci Inst, Tehran, Iran.
   [Larijani, Bagher] Univ Tehran Med Sci, Endocrinol & Metab Res Ctr, Endocrinol & Metab Clin Sci Inst, Tehran, Iran.
   [Azadbakht, Leila] Univ Tehran Med Sci, Diabet Res Ctr, Endocrinol & Metab Clin Sci Inst, Tehran, Iran.
C3 Tehran University of Medical Sciences; Tehran University of Medical
   Sciences; Alborz University of Medical Sciences; Tehran University of
   Medical Sciences; Tehran University of Medical Sciences; Tehran
   University of Medical Sciences; Tehran University of Medical Sciences
RP Azadbakht, L (corresponding author), Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Community Nutr, POB 1416643931, Tehran, Iran.
EM azadbakhtleila@gmail.com
RI Azadbakht, Leila/N-2801-2018; larijani, Bagher/ABE-3315-2020; keshavarz,
   Seyed/AAD-3261-2019; Qorbani, Mostafa/M-8171-2017; Daneshzad,
   Elnaz/O-3694-2018
OI Daneshzad, Elnaz/0000-0003-1400-8532; Larijani,
   Bagher/0000-0001-5386-7597
FU Tehran University of Medical Sciences and Health Services
   [96-03-161-36923]
FX This study is supported by Tehran University of Medical Sciences and
   Health Services (grant number: 96-03-161-36923). We would like to
   express our thankfulness to Dr. Nasli, secretary of the Diabetes
   Research Center of Tehran University of Medical Sciences, and all staffs
   in this center in Tehran, Iran.
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NR 65
TC 49
Z9 49
U1 0
U2 16
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2405-4577
J9 CLIN NUTR ESPEN
JI Clin. Nutr. ESPEN
PD JUN
PY 2020
VL 37
BP 187
EP 194
DI 10.1016/j.clnesp.2020.03.002
PG 8
WC Nutrition & Dietetics
WE Emerging Sources Citation Index (ESCI)
SC Nutrition & Dietetics
GA LL9AD
UT WOS:000531844200006
PM 32359742
DA 2025-06-11
ER

PT J
AU Moorthy, R
   Dinesh, AJ
   Annamalai, MM
AF Moorthy, Renasre
   Dinesh, A. John
   Annamalai, Melody Munusamy
TI Metabolic Syndrome in Patients with Depressive Disorder: A
   Cross-sectional Study
SO INDIAN JOURNAL OF PSYCHOLOGICAL MEDICINE
LA English
DT Article; Early Access
DE Depression; Metabolic syndrome; Dysthymia; Hamilton Depression Rating
   Scale; Determinants; Prevalence; India
ID 3RD NATIONAL-HEALTH; RISK; METAANALYSIS; PREVALENCE; COMPONENTS;
   MORTALITY; OBESITY; ADULTS
AB Background: Depression not only fosters the development of metabolic syndrome through behavioral, physiological, genetic, and treatment-related factors, but it also doubles the risk of experiencing metabolic syndrome. The objectives were to assess the sociodemographic and clinical profile of patients with depressive disorder, to assess the various metabolic parameters of metabolic syndrome in patients with depressive disorder, and to study the association between the severity of depression and metabolic syndrome. Methods: A cross-sectional study was conducted among patients diagnosed with depression (n = 160) attending the Psychiatry outpatient department of a tertiary healthcare facility in Puducherry. The Hamilton Depression Rating Scale (HAM-D) and modified National Cholesterol Education Program-Adult Treatment Panel-III (NCEP ATP-III) criteria were used to assess the severity of depression and diagnose metabolic syndrome, respectively. Results: The mean age at onset of depression was 31.4 years (+11.3); the duration of depression was 41.2 months (+32.5); and the severity of depression as assessed using the HAM-D was 17.9 (+6.3). The results showed that 27.5% of patients had metabolic syndrome. Factors associated with higher rates of metabolic syndrome included increasing age, female gender (79.5%), being single (25.0%), belonging to upper socioeconomic class (65.9%), non-Hindu religion (20.5%), and urban residence (72.7%) (P < .05). Patients with metabolic syndrome had later onset (36.4 years) and longer duration (51.6 months) of depression, more severe symptoms (18.2), and were more likely to have recurrent depressive disorder or dysthymia (88.6%) (P < .05). Furthermore, the current use of psychotropic medications (59.1%) and obesity (93.2%) were significantly associated with metabolic syndrome (P < .05). Conclusion: This study reveals a high prevalence of metabolic syndrome among patients with depressive disorders linked to factors such as age, gender, marital status, socioeconomic status, religion, and urban residence. Integrated care approaches, including comprehensive screening and targeted interventions, are crucial for improving both mental and metabolic health outcomes.
C1 [Moorthy, Renasre; Annamalai, Melody Munusamy] Vinayaka Missions Res Fdn VMRF DU, Aarupadai Veedu Med Coll, Dept Psychiat, Pondicherry, India.
C3 Vinayaka Mission's Research Foundation; Aarupadai Veedu Medical College
   & Hospital
RP Moorthy, R (corresponding author), Aarupadai Veedu Med Coll, Dept Psychiat, Pondicherry 607402, India.
EM renu.aaru@gmail.com
OI Cowan, Charles/0009-0001-0841-0130
CR Al-Khatib Y, 2022, CUREUS J MED SCIENCE, V14, DOI 10.7759/cureus.22153
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NR 37
TC 0
Z9 0
U1 3
U2 3
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0253-7176
EI 0975-1564
J9 INDIAN J PSYCHOL MED
JI Indian J. Psychol. Med.
PD 2025 JAN 19
PY 2025
DI 10.1177/02537176241309032
EA JAN 2025
PG 8
WC Psychiatry; Psychology
WE Emerging Sources Citation Index (ESCI)
SC Psychiatry; Psychology
GA S6A6W
UT WOS:001399032200001
PM 39839149
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Krishnaveni, GV
   Veena, SR
   Dhube, A
   Karat, SC
   Phillips, DIW
   Fall, CHD
AF Krishnaveni, G. V.
   Veena, S. R.
   Dhube, A.
   Karat, S. C.
   Phillips, D. I. W.
   Fall, C. H. D.
TI Size at birth, morning cortisol and cardiometabolic risk markers in
   healthy Indian children
SO CLINICAL ENDOCRINOLOGY
LA English
DT Article
ID CORTICOSTEROID-BINDING GLOBULIN; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   SERUM CORTISOL; PRENATAL STRESS; UNITED-KINGDOM; BLOOD-PRESSURE;
   NEONATAL PIGS; LATER LIFE; WEIGHT
AB ObjectivePrenatal programming of the hypothalamic-pituitary-adrenal (HPA) axis may link reduced foetal growth with higher adult chronic disease risk. South Asians have a high prevalence of low birth weight and a thin-fat phenotype, which is associated with subsequent type 2 diabetes and the metabolic syndrome. Altered HPA activity could be one of the pathological processes underlying this link.
   MethodsPlasma morning cortisol and corticosteroid-binding globulin (CBG) concentrations were determined in 528 children aged 95years from a prospective birth cohort in India. They had detailed anthropometry at birth, and current measurements of anthropometry, plasma glucose, insulin and lipid concentrations and blood pressure. Insulin resistance (Homeostasis Model Assessment) and insulin secretion (the 30-min insulin increment) were also assessed.
   ResultsNone of the birth measurements were associated with cortisol concentrations, but both birth weight (P=003) and length (P=0004) were inversely associated with CBG concentrations. Cortisol concentrations were inversely associated with current body mass index (P=002), and positively associated with glucose (fasting: P<0001; 30-min: P=0002) concentrations, and systolic blood pressure (P=0005), but not insulin resistance or the insulin increment.
   ConclusionHigher morning cortisol is associated with higher cardiometabolic risk markers in Indian children. Although cortisol concentrations did not appear to be related to birth size, small size at birth was associated with higher CBG levels, and may be one of the processes by which foetal undernutrition affects adult health. The findings suggest a need for dynamic testing of HPA axis activity (such as measuring stress responses).
C1 [Krishnaveni, G. V.; Veena, S. R.; Dhube, A.; Karat, S. C.] CSI Holdsworth Mem Hosp, Epidemiol Res Unit, Mysore 570021, South India, India.
   [Phillips, D. I. W.; Fall, C. H. D.] Southampton Gen Hosp, MRC Lifecourse Epidemiol Unit, Southampton SO9 4XY, Hants, England.
C3 University of Southampton
RP Krishnaveni, GV (corresponding author), CSI Holdsworth Mem Hosp, Epidemiol Res Unit, POB 38, Mysore 570021, South India, India.
EM gv.krishnaveni@gmail.com
OI Krishnaveni, Ghattu V/0000-0002-6532-8272; Fall,
   Caroline/0000-0003-4402-5552
FU Parthenon Trust, Switzerland; Wellcome Trust, UK; Medical Research
   Council, UK; MRC [MC_UU_12011/3, MC_UP_A620_1016] Funding Source: UKRI
FX We are grateful to the families who participated, and the obstetric and
   paediatric consultants. We thank Dr Jacqui Hill and staff at the
   Epidemiology Research Unit and the MRC Lifecourse Epidemiology Unit for
   their contributions. Our thanks to Dattatray Bhat, Diabetes Unit, KEM
   Hospital, Pune for biochemical assays, and to Sneha-India for its
   support.This study was funded by the Parthenon Trust, Switzerland, the
   Wellcome Trust, UK and the Medical Research Council, UK.
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NR 35
TC 15
Z9 17
U1 0
U2 7
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0300-0664
EI 1365-2265
J9 CLIN ENDOCRINOL
JI Clin. Endocrinol.
PD JAN
PY 2014
VL 80
IS 1
BP 73
EP 79
DI 10.1111/cen.12143
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 263IJ
UT WOS:000327801300010
PM 23297873
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Suetani, S
   Mamun, A
   Williams, GM
   Najman, JM
   McGrath, JJ
   Scott, JG
AF Suetani, Shuichi
   Mamun, Abdullah
   Williams, Gail M.
   Najman, Jake M.
   McGrath, John J.
   Scott, James G.
TI Longitudinal association between physical activity engagement during
   adolescence and mental health outcomes in young adults: A 21-year birth
   cohort study
SO JOURNAL OF PSYCHIATRIC RESEARCH
LA English
DT Article
DE Physical activity; Common mental disorders; Psychotic disorders;
   Longitudinal study; Epidemiology
ID CARDIOMETABOLIC RISK-FACTORS; AGE-OF-ONSET; SPORT PARTICIPATION;
   DEPRESSIVE SYMPTOMS; DELUSIONAL IDEATION; MATER-UNIVERSITY; LIFE
   EXPECTANCY; DISORDERS; PEOPLE; ANXIETY
AB Objective: Previous studies provide mixed evidence that physical activity engagement (PAE) in adolescence is associated with later mental health outcomes. This study aimed to examine the association between PAE at age 14 and mental health outcomes at age 21 using a large birth cohort study.
   Material and methods: Prospective data from the Mater-University of Queensland Study of Pregnancy, consisting of 3493 young adults, were analyzed. PAE at age 14 was estimated using self-report, and participants were categorized into; (1) frequent, (2) infrequent, or (3) no PAE group. Mental health outcomes at age 21 consisted of; (1) common mental disorders, (2) psychosis-related outcomes, and, (3) emotional and behavioral problems. The association between PAE in adolescence and later mental health outcomes in young adulthood was examined using logistic regression, adjusted for age, sex, body mass index, and adolescent psychopathology.
   Results: No PAE at age 14 was associated with the increased likelihood of lifetime diagnosis of any affective disorder, elevated delusional ideation, and endorsement of visual perceptual disturbance at age 21. Conversely, infrequent PAE at age 14 was associated with the decreased likelihood of subsequent lifetime diagnosis of any substance use disorder.
   Conclusion: Our findings suggest that lack of PAE in adolescence influences some, but not all, later mental health outcomes. Interventions to increase PAE in adolescence may represent an opportunity to prevent future mental health problems. (C) 2017 Elsevier Ltd. All rights reserved.
C1 [Suetani, Shuichi; McGrath, John J.; Scott, James G.] Queensland Ctr Mental Hlth Res, Pk Ctr Mental Hlth, Wacol, Qld 4076, Australia.
   [Suetani, Shuichi; McGrath, John J.] Univ Queensland, Queensland Brain Inst, St Lucia, Qld, Australia.
   [Suetani, Shuichi] Metro South Addict & Mental Hlth Serv, Brisbane, Qld, Australia.
   [Mamun, Abdullah] Univ Queensland, Inst Social Sci Res, Indooroopilly, Qld, Australia.
   [Williams, Gail M.; Najman, Jake M.] Univ Queensland, Sch Populat Hlth, Herston, Qld, Australia.
   [Najman, Jake M.] Univ Queensland, Sch Social Sci, St Lucia, Qld, Australia.
   [McGrath, John J.] Aarhus Univ, Natl Ctr Register Based Res, Aarhus C, Denmark.
   [Scott, James G.] Univ Queensland, Ctr Clin Res, Herston, Qld, Australia.
   [Scott, James G.] Royal Brisbane & Womens Hosp, Metro North Mental Hlth, Herston, Qld, Australia.
C3 Queensland Centre for Mental Health Research; University of Queensland;
   University of Queensland; University of Queensland; University of
   Queensland; Aarhus University; University of Queensland; Royal Brisbane
   & Women's Hospital
RP Suetani, S (corresponding author), Queensland Ctr Mental Hlth Res, Pk Ctr Mental Hlth, Wacol, Qld 4076, Australia.
EM shuichi.suetani@health.qld.gov.au
RI Williams, Gail/S-8833-2019; Najman, Jackob/B-1527-2008; McGrath,
   John/G-5493-2010; Scott, James/D-5900-2012; Mamun, Abdullah/A-4673-2011
OI Suetani, Shuichi/0000-0002-2487-5691; Najman,
   Jackob/0000-0001-7079-2080; McGrath, John/0000-0002-4792-6068; Scott,
   James/0000-0002-0744-0688; Mamun, Abdullah/0000-0002-1535-8086;
   Williams, Gail/0000-0002-4822-5263
FU National Health and Medical Research Council (NHMRC grant) [1009460];
   National Health and Medical Research Council Practitioner Fellowship
   Grant [1105807]; National Health and Medical Research Council
   [APP1056929]
FX The MUSP is funded by the National Health and Medical Research Council
   (NHMRC grant #1009460). James G Scott is supported by a National Health
   and Medical Research Council Practitioner Fellowship Grant #1105807 John
   McGrath received John Cade Fellowship APP1056929 from the National
   Health and Medical Research Council.
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NR 53
TC 21
Z9 23
U1 0
U2 46
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-3956
EI 1879-1379
J9 J PSYCHIATR RES
JI J. Psychiatr. Res.
PD NOV
PY 2017
VL 94
BP 116
EP 123
DI 10.1016/j.jpsychires.2017.06.013
PG 8
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA FJ7TD
UT WOS:000412960900015
PM 28704729
DA 2025-06-11
ER

PT J
AU Basu, A
AF Basu, Arpita
TI Role of Berry Bioactive Compounds on Lipids and Lipoproteins in Diabetes
   and Metabolic Syndrome
SO NUTRIENTS
LA English
DT Article
DE Lipids; Lipoproteins; cranberry; blueberry; strawberry; LDL; metabolic
   syndrome
ID HDL-CHOLESTEROL CONCENTRATIONS; CRANBERRY JUICE CONSUMPTION;
   EUTERPE-OLERACEA MART.; ESTER TRANSFER PROTEIN; C-REACTIVE PROTEIN;
   OXIDATIVE STRESS; BLOOD-PRESSURE; CARDIOVASCULAR-DISEASE;
   CARDIOMETABOLIC RISK; INSULIN-RESISTANCE
AB Blood lipids are an important biomarker of cardiovascular health and disease. Among the lipid biomarkers that have been widely used to monitor and predict cardiovascular diseases (CVD), elevated LDL and low HDL cholesterol (C), as well as elevated triglyceride-rich lipoproteins, deserve special attention in their predictive abilities, and thus have been the targets of several therapeutic and dietary approaches to improving lipid profiles. Among natural foods and nutraceuticals, dietary berries are a rich source of nutrients, fiber, and various types of phytochemicals. Berries as whole fruits, juices, and purified extracts have been shown to lower total and LDL-C, and increase HDL-C in clinical studies in participants with elevated blood lipids, type 2 diabetes or metabolic syndrome. This short review aimed to further discuss the mechanisms and magnitude of the lipid-lowering effects of dietary berries, with emphasis on reported clinical studies. Based on the emerging evidence, colorful berry fruits may thus be included in a healthy diet for the prevention and management of CVD.
C1 [Basu, Arpita] Univ Nevada, Sch Integrated Hlth Sci, Dept Kinesiol & Nutr Sci, 4505 S Maryland Pkwy, Las Vegas, NV 89154 USA.
C3 Nevada System of Higher Education (NSHE); University of Nevada Las Vegas
RP Basu, A (corresponding author), Univ Nevada, Sch Integrated Hlth Sci, Dept Kinesiol & Nutr Sci, 4505 S Maryland Pkwy, Las Vegas, NV 89154 USA.
EM Arpita.basu@unlv.edu
CR [Anonymous], ARCH INTERN MED
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NR 51
TC 27
Z9 28
U1 3
U2 17
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD SEP
PY 2019
VL 11
IS 9
AR 1983
DI 10.3390/nu11091983
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA JA6PP
UT WOS:000487964600062
PM 31443489
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Oliveira, CP
   Sanches, PD
   de Abreu-Silva, EO
   Marcadenti, A
AF Oliveira, Claudia P.
   Sanches, Priscila de Lima
   de Abreu-Silva, Erlon Oliveira
   Marcadenti, Aline
TI Nutrition and Physical Activity in Nonalcoholic Fatty Liver Disease
SO JOURNAL OF DIABETES RESEARCH
LA English
DT Review
ID MODERATE ALCOHOL-CONSUMPTION; HEPATIC STEATOSIS; INSULIN-RESISTANCE;
   MEDITERRANEAN DIET; WEIGHT-LOSS; METABOLIC SYNDROME; OXIDATIVE STRESS;
   SKELETAL-MUSCLE; RISK-FACTORS; VITAMIN-E
AB Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide and it is associated with other medical conditions such as diabetes mellitus, metabolic syndrome, and obesity. The mechanisms of the underlying disease development and progression are not completely established and there is no consensus concerning the pharmacological treatment. In the gold standard treatment for NAFLD weight loss, dietary therapy, and physical activity are included. However, little scientific evidence is available on diet and/or physical activity and NAFLD specifically. Many dietary approaches such asMediterranean and DASH diet are used for treatment of other cardiometabolic risk factors such as insulin resistance and type-2 diabetes mellitus (T2DM), but on the basis of its components their role in NAFLD has been discussed. In this review, the implications of current dietary and exercise approaches, including Brazilian and other guidelines, are discussed, with a focus on determining the optimal nonpharmacological treatment to prescribe for NAFLD.
C1 [Oliveira, Claudia P.] Univ Sao Paulo, Sch Med, Dept Gastroenterol, BR-05403900 Sao Paulo, SP, Brazil.
   [Sanches, Priscila de Lima] Fed Univ Sao Paulo UNIFESP, Postgrad Program Nutr, BR-04020060 Sao Paulo, SP, Brazil.
   [de Abreu-Silva, Erlon Oliveira] Fed Univ Sao Paulo UNIFESP, Div Intervent Cardiol, BR-04024002 Sao Paulo, SP, Brazil.
   [de Abreu-Silva, Erlon Oliveira] Fed Univ Sao Paulo UNIFESP, Postgrad Program Cardiol, BR-04024002 Sao Paulo, SP, Brazil.
   [Marcadenti, Aline] Fed Univ Hlth Sci Porto Alegre UFCSPA, Dept Nutr, Ctr Hist, BR-90050170 Porto Alegre, RS, Brazil.
   [Marcadenti, Aline] Inst Cardiol Rio Grande do Sul IC FUC, Postgrad Program Hlth Sci Cardiol, BR-90040371 Porto Alegre, RS, Brazil.
C3 Universidade de Sao Paulo; Universidade Federal de Sao Paulo (UNIFESP);
   Universidade Federal de Sao Paulo (UNIFESP); Universidade Federal de Sao
   Paulo (UNIFESP); Universidade Federal de Ciencias da Saude de Porto
   Alegre; Fundacao Universitaria de Cardiologia
RP Marcadenti, A (corresponding author), Fed Univ Hlth Sci Porto Alegre UFCSPA, Dept Nutr, Ctr Hist, 245 Sarmento Leite St, BR-90050170 Porto Alegre, RS, Brazil.
EM marcadenti@yahoo.com.br
RI Oliveira, Claudia/D-1216-2014; de Abreu Silva, Erlon/AAV-2842-2020;
   Marcadenti, Aline/A-8085-2012
OI P Oliveira, Claudia/0000-0002-2848-417X; Oliveira de Abreu-Silva,
   Erlon/0000-0003-1089-0716
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NR 92
TC 44
Z9 45
U1 0
U2 20
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2314-6745
EI 2314-6753
J9 J DIABETES RES
JI J. Diabetes Res.
PY 2016
VL 2016
AR 4597246
DI 10.1155/2016/4597246
PG 12
WC Endocrinology & Metabolism; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Research & Experimental Medicine
GA DB2VD
UT WOS:000368367300001
PM 26770987
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Brborovic, O
   Rukavina, TV
   Pavlekovic, G
   Dzakula, A
   Sogoric, S
   Vuletic, S
AF Brborovic, Ognjen
   Rukavina, Tea Vukusic
   Pavlekovic, Gordana
   Dzakula, Aleksandar
   Sogoric, Selma
   Vuletic, Silvije
TI Psychological Distress within Cardiovascular Risks Behaviors, Conditions
   and Diseases Conceptual Framework
SO COLLEGIUM ANTROPOLOGICUM
LA English
DT Article
DE psychological distress; cardiovascular disease; health behavior;
   Croatian Adult Health Survey; Croatia
ID CORONARY-HEART-DISEASE; SF-36 HEALTH SURVEY; MENTAL-HEALTH; METABOLIC
   SYNDROME; GENERAL-POPULATION; PROSPECTIVE COHORT; MAJOR DEPRESSION;
   WHITEHALL-II; VALIDITY; EPIDEMIOLOGY
AB Psychological distress (PD) is being increasingly recognized as a risk factor for cardiovascular diseases (CVD). Our aim was to recognize an association of PD and CVD in the Croatian adult population. We also explored association's strength obtainable as relative risk of PD on three levels; cardiovascular risk behaviors, conditions and diseases. This study used Croatian Adult Health Survey 2003 (CAHS 2003) data (N = 9,070). PD status was measured by the five-item Mental Health Scale of the Short Form questionnaire (SF-36) hence one distinguished subgroup consisted of population with PD and other without PD. Prevalence of cardiovascular risk behaviors, cardiovascular risk conditions and self-reported cardiovascular diseases within each subgroup were calculated using bootstrap method. Women had higher prevalence of PD in general population. Among distressed population women had higher prevalence of body mass index over 30, metabolic syndrome and angina pectoris. Men with PD had higher prevalence of high blood pressure and myocardial infarction with contradictoty lower prevalence of angina pectoris then Myocardial infarction. Physical inactivity was proven to be a risk behavior determinant with most impact on Mental health. All CVD are consistently associated with higher prevalence and relative risks for PD both in men and women.
C1 [Brborovic, Ognjen; Pavlekovic, Gordana; Dzakula, Aleksandar; Sogoric, Selma] Univ Zagreb, Sch Med, Andrija Stampar Sch Publ Hlth, Dept Social Med & Org Healthcare, Zagreb 10000, Croatia.
   [Rukavina, Tea Vukusic] Univ Zagreb, Sch Med, Andrija Stampar Sch Publ Hlth, Dept Med Sociol & Hlth Econ, Zagreb 10000, Croatia.
   [Vuletic, Silvije] Univ Zagreb, Sch Med, Andrija Stampar Sch Publ Hlth, Dept Med Stat Epidemiol & Med Informat, Zagreb 10000, Croatia.
C3 University of Zagreb; University of Zagreb; University of Zagreb
RP Brborovic, O (corresponding author), Univ Zagreb, Sch Med, Andrija Stampar Sch Publ Hlth, Dept Social Med & Org Healthcare, Rockefellerova 4, Zagreb 10000, Croatia.
EM obrborov@snz.hr
RI Vukusic Rukavina, Tea/ABH-3238-2021; Sogoric, Selma/LEM-9765-2024;
   Brborovic, Ognjen/AAF-1651-2020; Dzakula, Aleksandar/ITT-3971-2023
OI Sogoric, Selma/0000-0002-2314-2146; Dzakula,
   Aleksandar/0000-0002-0013-3108; Vukusic Rukavina,
   Tea/0000-0002-6466-9024
CR ASSOCIATION AH, 2008, OUR 2006 DIET LIF RE
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NR 35
TC 10
Z9 11
U1 0
U2 9
PU COLLEGIUM ANTROPOLOGICUM
PI ZAGREB
PA INST ANTHROPOLOGICAL RESEARCH, GAJEVA 32, PO BOX 290, HR-10000 ZAGREB,
   CROATIA
SN 0350-6134
J9 COLLEGIUM ANTROPOL
JI Coll. Anthropol.
PD APR
PY 2009
VL 33
SU 1
BP 93
EP 98
PG 6
WC Anthropology
WE Social Science Citation Index (SSCI)
SC Anthropology
GA 446KR
UT WOS:000266121000016
PM 19563153
DA 2025-06-11
ER

PT J
AU Takeuchi, T
   Nakao, M
   Kachi, Y
   Yano, E
AF Takeuchi, Takeaki
   Nakao, Mutsuhiro
   Kachi, Yuko
   Yano, Eiji
TI Association of metabolic syndrome with atypical features of depression
   in Japanese people
SO PSYCHIATRY AND CLINICAL NEUROSCIENCES
LA English
DT Article
DE atypical depression; hyperphagia; Japan; major depression; metabolic
   syndrome
ID MAJOR DEPRESSION; HEALTH; ANXIETY; SYMPTOMATOLOGY; POPULATION;
   PREVALENCE; SYMPTOMS; RISK
AB AimIt has been controversial whether metabolic syndrome (MetS) is associated with depression. We aimed to clarify the correlation between MetS and depression, considering atypical features of depression.
   MethodsParticipants were 1011 Japanese men aged 20-59 years. MetS was diagnosed according to criteria set by the International Diabetes Federation. Clinical interviews for major depressive disorder (MDD) employed the DSM-IV; MDD was classified into atypical and non-atypical types. The prevalence of MetS was compared between the groups with no MDD, atypical depression, and non-atypical depression via trend analyses. Multiple logistic regression analyses examined the association of MetS with atypical depression and the features thereof.
   ResultsIn total, 141 (14.0%) participants were diagnosed with MetS and 57 (5.6%) were diagnosed with MDD (14 had atypical and 43 had non-atypicalMDD). The prevalence of MetS was the highest in the group with atypical depression, followed by the non-atypical depression and no MDD groups, respectively, with a marginally significant trend (P=0.07). The adjusted odds ratios of MetS associated with depression were 3.8 (95% confidence interval [CI] 1.1-13.2) for atypical depression and 1.6 (95%CI 0.7-3.6) for non-atypical depression. Among the five features of atypical depression, only hyperphagia was significantly related to MetS (odds ratio 2.7, 95%CI 1.8-4.1).
   ConclusionThere was a positive association between MetS and atypical depression, but not between MetS and non-atypical depression. Specifically, hyperphagia seems to be an important factor affecting the correlation between MetS and atypical depression.
C1 [Takeuchi, Takeaki; Nakao, Mutsuhiro; Kachi, Yuko; Yano, Eiji] Teikyo Univ, Sch Med, Dept Hyg & Publ Hlth, Tokyo 1738605, Japan.
   [Takeuchi, Takeaki; Nakao, Mutsuhiro] Teikyo Univ Hosp, Div Psychosomat Med, Tokyo, Japan.
C3 Teikyo University; Teikyo University
RP Takeuchi, T (corresponding author), Teikyo Univ, Sch Med, Dept Hyg & Publ Hlth, Itabashi Ku, 2-11-1 Kaga, Tokyo 1738605, Japan.
EM takeakij@post.harvard.edu
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NR 33
TC 32
Z9 34
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1323-1316
EI 1440-1819
J9 PSYCHIAT CLIN NEUROS
JI Psychiatry Clin. Neurosci.
PD NOV
PY 2013
VL 67
IS 7
BP 532
EP 539
DI 10.1111/pcn.12104
PG 8
WC Clinical Neurology; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA 239OA
UT WOS:000326033900009
PM 24152284
OA Bronze
DA 2025-06-11
ER

PT S
AU Shen, J
   Wilmot, KA
   Ghasemzadeh, N
   Molloy, DL
   Burkman, G
   Mekonnen, G
   Gongora, MC
   Quyyumi, AA
   Sperling, LS
AF Shen, Jia
   Wilmot, Kobina A.
   Ghasemzadeh, Nima
   Molloy, Daniel L.
   Burkman, Gregory
   Mekonnen, Girum
   Gongora, Maria C.
   Quyyumi, Arshed A.
   Sperling, Laurence S.
BE Bowman, BA
   Stover, PJ
TI Mediterranean Dietary Patterns and Cardiovascular Health
SO ANNUAL REVIEW OF NUTRITION, VOL 35
SE Annual Review of Nutrition
LA English
DT Review; Book Chapter
DE Mediterranean diet; cardiovascular disease; prevention; health
ID CORONARY-HEART-DISEASE; MODERATE ALCOHOL-CONSUMPTION;
   LOW-DENSITY-LIPOPROTEIN; INTIMA-MEDIA THICKNESS; RED MEAT CONSUMPTION;
   OLIVE OIL; BLOOD-PRESSURE; RISK-FACTORS; ENDOTHELIAL FUNCTION; METABOLIC
   SYNDROME
AB The Mediterranean dietary pattern has been linked with reduced cardiovascular disease incidence and mortality. Components of the Mediterranean diet associated with better cardiovascular health include low consumption of meat and meat products, moderate consumption of ethanol (mostly from wine), and high consumption of vegetables, fruits, nuts, legumes, fish, and olive oil. Increasing evidence indicates that the synergy among these components results in beneficial changes in intermediate pathways of cardiometabolic risk, such as lipids, insulin sensitivity, oxidative stress, inflammation, and vasoreactivity. As a result, consumption of a Mediterranean dietary pattern favorably affects numerous cardiovascular disease risk factors, such as dyslipidemia, hypertension, metabolic syndrome, and diabetes. Moreover, strong evidence links this dietary pattern with reduced cardiovascular disease incidence, reoccurrence, and mortality. This review evaluates the current evidence behind the cardioprotective effects of a Mediterranean dietary pattern.
C1 [Shen, Jia; Wilmot, Kobina A.; Ghasemzadeh, Nima; Mekonnen, Girum; Gongora, Maria C.; Quyyumi, Arshed A.; Sperling, Laurence S.] Emory Univ, Emory Clin Cardiovasc Res Inst, Atlanta, GA 30322 USA.
   [Shen, Jia; Wilmot, Kobina A.; Ghasemzadeh, Nima; Molloy, Daniel L.; Burkman, Gregory; Mekonnen, Girum; Gongora, Maria C.; Quyyumi, Arshed A.; Sperling, Laurence S.] Emory Univ, Dept Med, Div Cardiol, Atlanta, GA 30322 USA.
C3 Emory University; Emory University
RP Shen, J (corresponding author), Emory Univ, Emory Clin Cardiovasc Res Inst, Atlanta, GA 30322 USA.
EM lsperli@emory.edu
FU Abraham J. and Phyllis Katz Foundation Preventive Cardiology Grant
FX The Abraham J. and Phyllis Katz Foundation Preventive Cardiology Grant
   supported this work. The funder had no role in the decision to publish
   the manuscript or in its preparation.
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NR 144
TC 108
Z9 117
U1 0
U2 52
PU ANNUAL REVIEWS
PI PALO ALTO
PA 4139 EL CAMINO WAY, PO BOX 10139, PALO ALTO, CA 94303-0897 USA
SN 0199-9885
EI 1545-4312
BN 978-0-8243-2835-1
J9 ANNU REV NUTR
JI Annu. Rev. Nutr.
PY 2015
VL 35
BP 425
EP 449
DI 10.1146/annurev-nutr-011215-025104
PG 25
WC Nutrition & Dietetics
WE Book Citation Index – Science (BKCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA BD1QC
UT WOS:000358259600014
PM 25974696
OA Bronze
DA 2025-06-11
ER

PT J
AU Gueye, AB
   Pryslawsky, Y
   Trigo, JM
   Poulia, N
   Delis, F
   Antoniou, K
   Loureiro, M
   Laviolette, SR
   Vemuri, K
   Makriyannis, A
   Foll, B
AF Gueye, Aliou B.
   Pryslawsky, Yaroslaw
   Trigo, Jose M.
   Poulia, Nafsika
   Delis, Foteini
   Antoniou, Katerina
   Loureiro, Michael
   Laviolette, Steve R.
   Vemuri, Kiran
   Makriyannis, Alexandros
   Le Foll, Bernard
TI The CB1 Neutral Antagonist AM4113 Retains the Therapeutic
   Efficacy of the Inverse Agonist Rimonabant for Nicotine Dependence and
   Weight Loss with Better Psychiatric Tolerability
SO INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
LA English
DT Article
DE CB1 antagonism; nicotine reward; dopamine; anxiety; depression
ID FOOD-REINFORCED BEHAVIOR; CARDIOMETABOLIC RISK-FACTORS;
   SUSTAINED-RELEASE BUPROPION; YOHIMBINE-INDUCED INCREASES; CUE-INDUCED
   REINSTATEMENT; RECEPTOR PARTIAL AGONIST; SEEKING BEHAVIOR;
   SMOKING-CESSATION; ALCOHOL-SEEKING; BODY-WEIGHT
AB Background: Multiple studies suggest a pivotal role of the endocannabinoid system in regulating the reinforcing effects of various substances of abuse. Rimonabant, a CB 1 inverse agonist found to be effective for smoking cessation, was associated with an increased risk of anxiety and depression. Here we evaluated the effects of the CB 1 neutral antagonist AM4113 on the abuse-related effects of nicotine and its effects on anxiety and depressive-like behavior in rats.
   Methods: Rats were trained to self-administer nicotine under a fixed-ratio 5 or progressive-ratio schedules of reinforcement. A control group was trained to self-administer food. The acute/chronic effects of AM4113 pretreatment were evaluated on nicotine taking, motivation for nicotine, and cue-, nicotine priming-and yohimbine-induced reinstatement of nicotine-seeking. The effects of AM4113 in the basal firing and bursting activity of midbrain dopamine neurons were evaluated in a separate group of animals treated with nicotine. Anxiety/depression-like effects of AM4113 and rimonabant were evaluated 24 h after chronic (21 days) pretreatment (0, 1, 3, and 10 mg/kg, 1/d).
   Results: AM4113 significantly attenuated nicotine taking, motivation for nicotine, as well as cue-, priming-and stress-induced reinstatement of nicotine-seeking behavior. These effects were accompanied by a decrease of the firing and burst rates in the ventral tegmental area dopamine neurons in response to nicotine. On the other hand, AM4113 pretreatment did not have effects on operant responding for food. Importantly, AM4113 did not have effects on anxiety and showed antidepressant-like effects.
   Conclusion: Our results indicate that AM4113 could be a promising therapeutic option for the prevention of relapse to nicotine-seeking while lacking anxiety/depression-like side effects.
C1 [Gueye, Aliou B.; Pryslawsky, Yaroslaw; Trigo, Jose M.; Le Foll, Bernard] Ctr Addict & Mental Hlth, Translat Addict Res Lab, 33 Russell St, Toronto, ON M5S 2S1, Canada.
   [Le Foll, Bernard] Ctr Addict & Mental Hlth, Alcohol Res & Treatment Clin, Addict Med Serv, Ambulatory Care & Structured Treatments, Toronto, ON, Canada.
   [Le Foll, Bernard] Ctr Addict & Mental Hlth, Campbell Family Mental Hlth Res Inst, Toronto, ON, Canada.
   [Le Foll, Bernard] Univ Toronto, Dept Pharmacol, Dept Family & Community Med, Toronto, ON, Canada.
   [Le Foll, Bernard] Univ Toronto, Dept Psychiat, Div Brain & Therapeut, Toronto, ON, Canada.
   [Le Foll, Bernard] Univ Toronto, Inst Med Sci, Toronto, ON, Canada.
   [Poulia, Nafsika; Delis, Foteini; Antoniou, Katerina] Univ Ioannina, Fac Med, Sch Hlth Sci, Dept Pharmacol, Ioannina, Greece.
   [Loureiro, Michael; Laviolette, Steve R.] Univ Western Ontario, Schulich Sch Med & Dent, Dept Anat & Cell Biol, London, ON, Canada.
   [Vemuri, Kiran; Makriyannis, Alexandros] Northeastern Univ, Ctr Drug Discovery, Dept Pharmaceut Sci, Boston, MA 02115 USA.
   [Vemuri, Kiran; Makriyannis, Alexandros] Northeastern Univ, Dept Chem & Chem Biol, Boston, MA 02115 USA.
C3 University of Toronto; Centre for Addiction & Mental Health - Canada;
   University of Toronto; Centre for Addiction & Mental Health - Canada;
   University of Toronto; Centre for Addiction & Mental Health - Canada;
   University of Toronto; University of Toronto; University of Toronto;
   University of Ioannina; Western University (University of Western
   Ontario); Northeastern University; Northeastern University
RP Foll, B (corresponding author), Ctr Addict & Mental Hlth, Translat Addict Res Lab, 33 Russell St, Toronto, ON M5S 2S1, Canada.
EM Bernard.LeFoll@camh.ca
RI trigo, jose/C-2770-2011; Antoniou, Katerina/AAB-6062-2022; Makriyannis,
   Alexandros/GRF-1518-2022; Le Foll, Bernard/K-2952-2014
OI Loureiro, Michael/0000-0002-5915-5627; Le Foll,
   Bernard/0000-0002-6406-4973
FU Canadian Institutes of Health Research; NIDA; NIH
FX This work was supported by a grant from the Canadian Institutes of
   Health Research and NIDA, NIH.
CR [Anonymous], SAN AV DISC ALL CLIN
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NR 57
TC 57
Z9 62
U1 0
U2 8
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1461-1457
EI 1469-5111
J9 INT J NEUROPSYCHOPH
JI Int. J. Neuropsychopharmacol.
PD DEC
PY 2016
VL 19
IS 12
DI 10.1093/ijnp/pyw068
PG 11
WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA EK4QV
UT WOS:000393912800002
PM 27493155
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Bekyarova, G
   Kiselova-Kaneva, Y
   Madjov, V
   Gerova, D
   Bekyarov, N
   Todorova, M
   Stoeva, S
AF Bekyarova, Ganka
   Kiselova-Kaneva, Yoana
   Madjov, Valentina
   Gerova, Daniela
   Bekyarov, Nicolay
   Todorova, Monica
   Stoeva, Stefka
TI The predictable role37 of adma and oxidative stress in endothelial
   dysfunction-a pilot study
SO JOURNAL OF IMAB
LA English
DT Article; Proceedings Paper
CT 13th South-East European Conference of Chemotherapy, Infections and
   Cancer and 33rd Annual Assembly of
   International-Medical-Association-Bulgaria (SEEC/IMAB)
CY OCT 12-15, 2023
CL Belgrade, SERBIA
SP Int Med Assoc Bulgaria
DE ADMA; oxidative stress; endothelial dysfunction; metabolic syndrome
ID ASYMMETRIC DIMETHYLARGININE ADMA; BIOLOGY
AB The aim of the study was to examine the plasma levels ADMA, MDA and lipid markers in people with metabolic syndrome as well as in clinically asymptomatic people. We further studied whether such elevation of ADMA as marker of endothelial dysfunction was correlated with oxidative stress and conventional risk factors.
   According to modified ATP III criteria the participants (52 females, 8 males) of the study were divided in four group: G1, n=19 people with MetS; G2, n=12 peoples with genetic predisposition and risk for MetS; G3, n=15 people with unhealthy life style and risk of MetS and Control group n=14). The study revealed significant differences between people groups with and without anamnestic data of MetS in terms of ADMA, MDA and lipid markers. Plasma levels of ADMA and MDA in G1 were significantly higher (p<0.001) compared to these of G3. The levels of lipid markers (TG, TChol and LDL-C, HDL-C) in G1 were close to the control. The levels of ADMA significantly correlated with plasma MDA levels. These results suggest a link between plasma ADMA and MDA as indicator of oxidative stress and their role as predictive biomarkers for of endothelial dysfunction and cardiometabolic risk.
C1 [Bekyarova, Ganka; Madjov, Valentina; Gerova, Daniela; Bekyarov, Nicolay; Todorova, Monica] Univ Prof Paraskev Stoyanov, Med Fac, Varna, Bulgaria.
   [Kiselova-Kaneva, Yoana; Stoeva, Stefka] Univ Prof Paraskev Stoyanov, Fac Pharm, Varna, Bulgaria.
C3 Medical University Varna
RP Bekyarova, G (corresponding author), Univ Prof Paraskev Stoyanov, Med Fac, Varna, Bulgaria.
CR Bekyarova G, 2007, Folia Medica, P13, DOI [10.1515/CCLM.2003.225, DOI 10.1515/CCLM.2003.225]
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NR 11
TC 0
Z9 0
U1 1
U2 2
PU Peytchinski Publishing Ltd
PI PLEVEN
PA compl. Droujba bl. 116, ap. 41, PLEVEN, BULGARIA
SN 1312-773X
J9 J IMAB
JI J. IMAB
PY 2022
VL 22
SU 1
BP 38
EP 41
PG 4
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA GP1J8
UT WOS:001153778000011
DA 2025-06-11
ER

PT J
AU Cen, MQ
   Song, LL
   Fu, XH
   Gao, XX
   Zuo, QL
   Wu, J
AF Cen, Manqiu
   Song, Lingling
   Fu, Xihang
   Gao, Xinxin
   Zuo, Qianlin
   Wu, Jing
TI Associations between metabolic syndrome and anxiety, and the mediating
   role of inflammation: Findings from the UK Biobank
SO BRAIN BEHAVIOR AND IMMUNITY
LA English
DT Article
DE Metabolic syndrome; Anxiety; Inflammation; UK Biobank
ID LOW-GRADE INFLAMMATION; BLOOD-CELL COUNT; STRATIFIED ANALYSIS;
   LIFE-STYLE; DEPRESSION; WHITE; DISORDERS; SYMPTOMS; SYSTEMS; STRESS
AB Objectives: To investigate the association between metabolic syndrome (MetS) and anxiety and to explore the mediating role of inflammation indicators in this relationship based on the UK Biobank prospective cohort. Methods: This population-based retrospective cohort study analyzed data from 308,352 participants. MetS was defined according to criteria jointly developed by the American Heart Association, the National Heart, Lung, and Blood Institute, and the International Diabetes Federation. Anxiety was defined using ICD-10 codes. Cox proportional risk regression models were used to explore the hazard ratios (HRs) between MetS, components of MetS, number of MetS components, and anxiety. The mediating effect of inflammation on the association between MetS and anxiety was explored using longitudinal mediation analysis. Results: A total of 308,352 participants were included in this study. Of these, 9471 (3.071 %) developed anxiety over a mean follow-up of 12.05 years. In the fully adjusted model, MetS increased the risk of anxiety by 13.6 % (HR: 1.136, 95 %CI: 1.085-1.189). All MetS components significantly increased the risk of anxiety, with HRs ranging from 1.066 to 1.165. When MetS was treated as a linear variable, the risk of anxiety increased by 6.5 % per component increment. Age-stratified results showed that the risk of MetS for anxiety was higher among those <55 years (HR: 1.23, 95 %CI: 1.13-1.33) than among those >= 55 years (HR: 1.12, 95 %CI: 1.06-1.18). The mediating effects of platelets, lymphocytes, neutrophils, C-reactive protein, leukocytes, and INFLA scores on the association between MetS and anxiety were significant, with mediating effects of 2.30 %, 7.20 %, 15.9 %, 20.7 %, 22.0 %, and 25.3 %, respectively, and a combined mediating effect of these inflammatory factors was 30.8 % (except for INFLA scores). Conclusions: MetS and its components significantly increased the risk of anxiety, which increased with the number of components. This association may be partially mediated by serum inflammatory indicators, suggesting that MetS may increase the risk of anxiety by elevating the level of chronic inflammation.
C1 [Cen, Manqiu; Song, Lingling; Fu, Xihang; Gao, Xinxin; Zuo, Qianlin; Wu, Jing] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Dept Epidemiol & Biostat, Wuhan 430030, Peoples R China.
   [Cen, Manqiu; Song, Lingling; Fu, Xihang; Gao, Xinxin; Zuo, Qianlin; Wu, Jing] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Minist Educ Key Lab Environm & Hlth, Wuhan 430030, Peoples R China.
   [Cen, Manqiu; Song, Lingling; Fu, Xihang; Gao, Xinxin; Zuo, Qianlin; Wu, Jing] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, State Key Lab Environm Hlth Incubating, Wuhan 430030, Peoples R China.
C3 Huazhong University of Science & Technology; Huazhong University of
   Science & Technology; Huazhong University of Science & Technology
RP Wu, J (corresponding author), Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Dept Epidemiol & Biostat, Wuhan 430030, Peoples R China.
EM wujingtj@hust.edu.cn
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NR 50
TC 28
Z9 29
U1 11
U2 29
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0889-1591
EI 1090-2139
J9 BRAIN BEHAV IMMUN
JI Brain Behav. Immun.
PD FEB
PY 2024
VL 116
BP 1
EP 9
DI 10.1016/j.bbi.2023.11.019
EA NOV 2023
PG 9
WC Immunology; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Neurosciences & Neurology; Psychiatry
GA CU5Z2
UT WOS:001127776800001
PM 37984624
DA 2025-06-11
ER

PT J
AU Vargas, HO
   Nunes, SOV
   de Castro, MP
   Bortolasci, CC
   Barbosa, DS
   Morimoto, HK
   Venugopal, K
   Dodd, S
   Maes, M
   Berk, M
AF Vargas, Heber Odebrecht
   Vargas Nunes, Sandra Odebrecht
   de Castro, Marcia Pizzo
   Bortolasci, Chiara Cristina
   Barbosa, Decio Sabbatini
   Morimoto, Helena Kaminami
   Venugopal, Kamalesh
   Dodd, Seetal
   Maes, Michael
   Berk, Michael
TI Oxidative stress and lowered total antioxidant status are associated
   with a history of suicide attempts
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Suicide; Oxidative stress; Inflammation; Metabolism; Depressive
   disorders; Nicotine dependence
ID C-REACTIVE PROTEIN; CIGARETTE-SMOKING; METABOLIC SYNDROME; DEPRESSIVE
   DISORDER; MAJOR DEPRESSION; INFLAMMATION; HEALTH; RISK; CHOLESTEROL;
   CYTOKINES
AB Background: There is evidence that depression is accompanied by inflammation, oxidative and nitrosative stress (O&NS) and metabolic disorders. However links between oxidative stress and suicide attempts in depressed patients are poorly understood. This study examines whether a history of suicide attempts is associated with inflammation, O&NS and metabolic disorders.
   Methods: Blood specimens were collected from study participants aged 18-60 (N=342) recruited at the State University of Londrina, Brazil, and measured for oxidative stress biomarkers: nitric oxide metabolites (NOx), lipid hydroperoxides, malondialdehyde, advanced oxidation protein products and plasma total antioxidant potential (TRAP); inflammatory biomarkers: fibrinogen, high sensitivity C-reactive protein, erythrocyte sedimentation rate, interleukin-6 and tumor necrosis factor-alpha; and metabolic variables. Subjects were divided into those with (n=141) and without (n=201) a history of suicidal attempts.
   Results: Individuals with a history of suicide attempts had significantly higher levels of NOx and lipid hydroperoxides and lowered TRAP as compared to individuals without suicide attempts. There were no significant associations between a history of suicide attempts and inflammatory and metabolic biomarkers and metabolic syndrome. Logistic regression showed that both unipolar and bipolar disorder, female gender, smoking behavior and lipid hydroperoxides were significantly associated with a history of suicide attempts. The combined effects of oxidative stress, smoking, depression, female gender were independent from classical risk factors, including marital status, years of education and anxiety.
   Conclusions: O&NS as well as lowered antioxidant levels may play a role in the pathophysiology of suicidal behavior independently from the effects of depression and smoking, both of which are associated with increased O&NS, and classical suicide predictors, such as years of education and marital status. (C) 2013 Published by Elsevier B.V.
C1 [Vargas, Heber Odebrecht; Vargas Nunes, Sandra Odebrecht] Univ Estadual Londrina, Dept Clin Med, Psychiat Unit, BR-86051990 Londrina, Brazil.
   [Vargas, Heber Odebrecht; Vargas Nunes, Sandra Odebrecht; de Castro, Marcia Pizzo; Bortolasci, Chiara Cristina] Ctr Approach & Treatment Smokers, Londrina, Parana, Brazil.
   [Barbosa, Decio Sabbatini; Morimoto, Helena Kaminami] Univ Estadual Londrina, Dept Clin Anal & Toxicol, BR-86051990 Londrina, Parana, Brazil.
   [Dodd, Seetal; Berk, Michael] Univ Melbourne, Dept Psychiat, Parkville, Vic 3052, Australia.
   [Venugopal, Kamalesh; Dodd, Seetal; Maes, Michael; Berk, Michael] Deakin Univ, Sch Med, Geelong, Vic 3217, Australia.
   [Berk, Michael] Univ Melbourne, Orygen Youth Hlth Res Ctr, Ctr Youth Mental Hlth, Parkville, Vic 3052, Australia.
   [Dodd, Seetal; Berk, Michael] Swanston Ctr, Barwon Hlth & Geelong Clin, Geelong, Vic 3220, Australia.
   [Berk, Michael] Florey Inst Neurosci & Mental Hlth, Parkville, Vic, Australia.
C3 Universidade Estadual de Londrina; Universidade Estadual de Londrina;
   University of Melbourne; Deakin University; Orygen, The National Centre
   of Excellence in Youth Mental Health; University of Melbourne; Florey
   Institute of Neuroscience & Mental Health
RP Vargas, HO (corresponding author), Univ Estadual Londrina, Dept Clin Med, Psychiat Unit, Rodovia Celso Garcia Cid 445,KM 380,Campus Univ, BR-86051990 Londrina, Brazil.
EM hebervargas@sercomtel.com.br
RI Nunes, Sandra/B-4035-2019; Barbosa, Décio/AAE-6351-2019; Maes,
   Michael/B-8546-2011; Venugopal, Kamalesh/NJT-2319-2025; Berk,
   Michael/AGH-9427-2022; Bortolasci, Chiara/C-7336-2016; Berk,
   Michael/M-7891-2013
OI Bortolasci, Chiara/0000-0002-0794-6363; Venugopal,
   Kamalesh/0000-0002-5611-6489; Dodd, Seetal/0000-0002-7918-4636; Maes,
   Michael/0000-0002-2012-871X; Berk, Michael/0000-0002-5554-6946
FU Londrina State University, Parana, Brazil (UEL); Brazilian Federal
   Agency for Support and Evaluation of Graduate Education (CAPES);
   Ministry for Science and Technology of Brazil (CNPq)
FX This study was supported by Health Sciences Postgraduate Program at
   Londrina State University, Parana, Brazil (UEL), Brazilian Federal
   Agency for Support and Evaluation of Graduate Education (CAPES) and
   Ministry for Science and Technology of Brazil (CNPq).
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NR 56
TC 112
Z9 116
U1 0
U2 19
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD SEP 25
PY 2013
VL 150
IS 3
BP 923
EP 930
DI 10.1016/j.jad.2013.05.016
PG 8
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA 213ER
UT WOS:000324038000030
PM 23856278
DA 2025-06-11
ER

PT J
AU Foley, DL
   Morley, KI
   Madden, PAF
   Heath, AC
   Whitfield, JB
   Martin, NG
AF Foley, Debra L.
   Morley, Katherine I.
   Madden, Pamela A. F.
   Heath, Andrew C.
   Whitfield, John B.
   Martin, Nicholas G.
TI Major Depression and the Metabolic Syndrome
SO TWIN RESEARCH AND HUMAN GENETICS
LA English
DT Article
DE depressive disorder; major; metabolic syndrome; cardiovascular diseases
ID MIDDLE-AGED MEN; ENVIRONMENTAL-CONTRIBUTIONS; YOUNG-ADULTS; TWIN SAMPLE;
   SYMPTOMS; HEALTH; RISK; WOMEN; CHOLESTEROL; DEPENDENCE
AB T he aim of this study is to characterize the relation! ship between major depression and the metabolic syndrome in a large community based sample of Australian men and women aged 26-90 years. A lifetime history of major depression was assessed by telephone interview following the DSM-III-R. A current history of metabolic syndrome was assessed following the United States National Cholesterol Education Program Adult Treatment Panel Ill (NCEP AP-III) guidelines 1 to 3 years later. Logistic regression was used to estimate the association between depression and the metabolic syndrome, and its component criteria, controlling for age, sex and alcohol dependence. There was no association between a lifetime history of major depression and the presence of the metabolic syndrome. There was a weak association between depression and low high-density lipoprotein cholesterol but not with other component criteria of the metabolic syndrome. Despite calls for interventions directed at depression to reduce the onset of the metabolic syndrome there are important failures to replicate in large samples such as this, no consensus regarding the threshold at which depression may pose a significant risk even allowing for heterogeneity across populations, and no consensus regarding confounders that may explain inter-study differences. The absence of any dosage effect of depression on the associated risk for the metabolic syndrome in other unselected samples does not support a direct causal relationship. The call for intervention studies on the basis of the currently published evidence base is unwarranted.
C1 [Foley, Debra L.] Univ Melbourne, Orygen Youth Hlth Res Ctr, Biostat Unit, Parkville, Vic 3052, Australia.
   [Foley, Debra L.] Univ Melbourne, Ctr Youth Mental Hlth, Parkville, Vic 3052, Australia.
   [Morley, Katherine I.] Wellcome Trust Sanger Inst, Cambridge, England.
   [Morley, Katherine I.] Univ Melbourne, Ctr Mol Environm Genet & Analyt Epidemiol, Sch Populat Hlth, Parkville, Vic 3052, Australia.
   [Madden, Pamela A. F.; Heath, Andrew C.] Washington Univ, Dept Psychiat, Sch Med, St Louis, MO 63130 USA.
   [Whitfield, John B.; Martin, Nicholas G.] Queensland Inst Med Res, Genet & Mol Epidemiol Labs, Brisbane, Qld 4006, Australia.
C3 University of Melbourne; Orygen, The National Centre of Excellence in
   Youth Mental Health; Orygen, The National Centre of Excellence in Youth
   Mental Health; University of Melbourne; Wellcome Trust Sanger Institute;
   University of Melbourne; Washington University (WUSTL); QIMR Berghofer
   Medical Research Institute
RP Foley, DL (corresponding author), Univ Melbourne, Orygen Youth Hlth Res Ctr, Biostat Unit, 35 Poplar Rd, Parkville, Vic 3052, Australia.
EM dfoley@unimelb.edu.au
RI Martin, Nicholas/R-9235-2019; Morley, Katherine/A-2986-2011
OI Morley, Katherine/0000-0002-2725-5535; Martin,
   Nicholas/0000-0003-4069-8020; Whitfield, John/0000-0002-1103-0876
FU American National Institute of Health [AA07535, AA13320, AA13326,
   AA014041]; Australian National Health and Medical Research Council
   [520452, 628911]; Colonial Foundation (Australia); Heart Foundation
   (Australia) [G09M4402]
FX American National Institute of Health grants have supported this work,
   including grants to Drs Andrew Heath (AA07535, AA13320), Nick Martin
   (AA13326), and John Whitfield (AA014041). Dr Katherine Morley is
   supported by a Public Health Fellowship from the Australian National
   Health and Medical Research Council (520452). Dr Debra Foley is
   supported by the Colonial Foundation (Australia) and the Heart
   Foundation (Australia) (G09M4402). We also acknowledge the Australian
   Twin Registry for ascertainment of twin subjects. The Australian Twin
   Registry is supported by enabling grant 628911 from the Australian
   National Health and Medical Research Council and administered by The
   University of Melbourne.
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NR 35
TC 57
Z9 58
U1 1
U2 5
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
SN 1832-4274
EI 1839-2628
J9 TWIN RES HUM GENET
JI Twin Res. Hum. Genet.
PD AUG
PY 2010
VL 13
IS 4
BP 347
EP 358
DI 10.1375/twin.13.4.347
PG 12
WC Genetics & Heredity; Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Genetics & Heredity; Obstetrics & Gynecology
GA 729ZW
UT WOS:000287994200007
PM 20707705
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Ferriani, LO
   Silva, DA
   Viana, MC
AF Ferriani, Lara Onofre
   Silva, Daniela Alves
   Viana, Maria Carmen
TI ATYPICAL DEPRESSION IS ASSOCIATED WITH METABOLIC SYNDROME: A SYSTEMATIC
   REVIEW
SO ACTAS ESPANOLAS DE PSIQUIATRIA
LA English
DT Review
DE Key words; Metabolic syndrome; atypical depression; depressive subtypes;
   systematic review; mental disorders
ID YOUNG-ADULTS; SYMPTOMS; SUBTYPES; COOCCURRENCE; ANXIETY; HEALTH
AB Introduction. Depression and metabolic syndrome (MetS) are important public health problems. This systematic review evaluated whether the atypical subtype of depression is associated with MetS, when compared to other depressive subtypes. Methods. Two independent reviewers searched in Medline, Lilacs, PsycInfo, Scopus and Web of Science databases, up to May 2021, without language restriction, including cross-sectional, case-control, and cohort studies, assessing adults. The methodological quality of the studies was assessed using the Newcastle-Ottawa Scale. The PRISMA guidelines were adopted and this review was registered in PROSPERO (CRD42018109762). Results. The databases search identified 96 articles and 6 was included in this review. The methodological quality scores ranged from 7 to 10 points. The association between atypical depression and MetS was demonstrated in all publications, as well as the lack of association with melancholic and other subtypes. The prevalence of MetS was significantly higher among individuals with atypical depression. It is worth noting that only few studies assessing this comorbidity were conducted so far. Conclusions. MetS is associated with atypical depression, but not with melancholic or other subtypes. The identification of distinct depressive clinical features seems crucial to better understand its comorbidity with MetS and elucidate its pathophysiological pathways, both necessary to better guide prevention and treatment strategies.
C1 [Ferriani, Lara Onofre] Univ Fed Espirito Santo, Programa Posgrad Salud Publ, Vitoria, Brazil.
   [Silva, Daniela Alves] Univ Fed Espirito Santo, Dept Educ Integrada Salud, Vitoria, Brazil.
   [Viana, Maria Carmen] Univ Fed Espirito Santo, Dept Med Social, Vitoria, Brazil.
   [Viana, Maria Carmen] Univ Fed Espirito Santo, Programa Posgrad Salud Publ, Vitoria, Brazil.
C3 Universidade Federal do Espirito Santo; Universidade Federal do Espirito
   Santo; Universidade Federal do Espirito Santo; Universidade Federal do
   Espirito Santo
RP Ferriani, LO (corresponding author), Univ Fed Espirito Santo, Programa Posgrad Salud Publ, Vitoria, Brazil.; Viana, MC (corresponding author), Univ Fed Espirito Santo, Dept Med Social, Vitoria, Brazil.; Viana, MC (corresponding author), Univ Fed Espirito Santo, Programa Posgrad Salud Publ, Vitoria, Brazil.
EM laraonofref@gmail.com; mcviana6@gmail.com
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NR 33
TC 1
Z9 1
U1 0
U2 0
PU JUAN JOSE LOPEZ-IBOR FOUNDATION
PI MADRID
PA NO 2, MADRID, 28035, SPAIN
SN 1139-9287
EI 1578-2735
J9 ACTAS ESP PSIQUIATRI
JI Actas Esp. Psiquiatri.
PD NOV-DEC
PY 2022
VL 50
IS 6
BP 266
EP 275
PG 10
WC Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Psychiatry
GA 8C6HQ
UT WOS:000917707500003
PM 36622714
DA 2025-06-11
ER

PT J
AU Kim, GU
   Kim, N
   Kim, H
AF Kim, Go-Un
   Kim, Namhee
   Kim, Heejung
TI Association between self-reported medical diagnosis of depression and
   metabolic syndrome in a population-based study: A propensity
   score-matched analysis
SO NURSING OPEN
LA English
DT Article
DE depression; metabolic syndrome; nursing; propensity score; triglycerides
ID SLEEP QUALITY; OBESITY; PREVALENCE; MANAGEMENT; GENDER; HEALTH; DIET
AB The aim was to compare the metabolic syndrome in adults with and without depression in Korea using the 2013-2015 Korea National Health and Nutrition Examination Survey. A cross-sectional study was conducted involving secondary data analysis. National survey data on the self-reported medical diagnosis of depression and metabolic syndrome were collected between 2013 and 2015 and released for research purposes in 2017. We conducted a propensity score-matched study that included adults (n = 494) with and without depression at a 1:1 ratio, to reduce the impact of potential confounding factors between groups. Depression was not significantly associated with changes in metabolic syndrome. However, participants with depression had significantly higher triglycerides than those without depression (p = .008), highlighting the importance of periodically checking triglycerides in depressed patients. Nurses need to check the subcomponents of metabolic syndrome in depressed patients periodically, especially regarding the management of triglycerides.
C1 [Kim, Go-Un; Kim, Namhee; Kim, Heejung] Yonsei Univ, Coll Nursing, 50-1 Yonsei Ro, Seoul 03722, South Korea.
   [Kim, Go-Un; Kim, Heejung] Yonsei Univ, Mo Im Kim Nursing Res Inst, 50-1 Yonsei Ro, Seoul 03722, South Korea.
   [Kim, Namhee] Yonsei Univ, Brain Korea 21 FOUR Project, Seoul, South Korea.
C3 Yonsei University; Yonsei University Health System; Yonsei University;
   Yonsei University
RP Kim, H (corresponding author), Yonsei Univ, Coll Nursing, 50-1 Yonsei Ro, Seoul 03722, South Korea.; Kim, H (corresponding author), Yonsei Univ, Mo Im Kim Nursing Res Inst, 50-1 Yonsei Ro, Seoul 03722, South Korea.
EM hkim80@yuhs.ac
OI Kim, Goun/0000-0001-7191-5134; Kim, Heejung/0000-0003-3719-0111; Kim,
   Namhee/0000-0002-2862-2691
FU Yonsei University College of Nursing; Ministry of Science, ICT and
   Future Planning [NRF-2020R1C1C1012848]; Mo-Im Kim Nursing Research
   Institute [6-2018-0179]
FX This study was supported by the Yonsei University College of Nursing and
   Mo-Im Kim Nursing Research Institute in 2018 (Grant ID: 6-2018-0179) and
   the Ministry of Science, ICT and Future Planning (NRF-2020R1C1C1012848).
   The funder had no role in the design, collection, analysis,
   interpretation, writing or submission decision of this article
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   ,, 2008, The global burden of disease: 2004 update
NR 47
TC 0
Z9 0
U1 1
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 2054-1058
J9 NURS OPEN
JI NURS. OPEN
PD JAN
PY 2022
VL 9
IS 1
BP 367
EP 376
DI 10.1002/nop2.1074
EA SEP 2021
PG 10
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA XT2GA
UT WOS:000700820500001
PM 34582126
OA Green Published
DA 2025-06-11
ER

PT J
AU Stanojevic, A
   Popovic, I
   Nenadovic, M
   Ravanic, D
   Paunovic-Milosavljevic, G
AF Stanojevic, Albina
   Popovic, Irena
   Nenadovic, Milutin
   Ravanic, Dragan
   Paunovic-Milosavljevic, Gordana
TI Metabolic Syndrome and C-Reactive Protein in Patients with Depressive
   Disorder on Antidepressive Medication
SO SRPSKI ARHIV ZA CELOKUPNO LEKARSTVO
LA English
DT Article
DE C-reactive protein; Metabolic Syndrome; depression; SSRI pharmacotherapy
ID 3RD NATIONAL-HEALTH; CARDIOVASCULAR-DISEASE; INFLAMMATORY MARKERS; MAJOR
   DEPRESSION; US ADULTS; PREVALENCE; ACTIVATION; MOOD
AB Introduction Recurrent depression is a psychiatric disorder of which etiology and pathogenesis might be related to immune response. Metabolic Syndrome (MetS) and its components are also strongly associated with elevated inflammatory indicators, as so as the body mass index (BMI) and total cholesterol levels.
   Objective Objective of this study was to investigate if there was any difference in C-reactive protein (CRP) levels in patients with recurrent depressive disorder, treated with antidepressants, compared to a healthy control group of subjects and if there was an association between increased CRP levels and the presence of MetS in these two groups.
   Methods Sixty subjects entered the study; of these 35 patients with the diagnosis of recurrent depressive disorder, while the healthy control group included 25 subjects. MetS was defined according to the NCEP ATP III criteria. The cut-off point for CRP was set at >5 mg /L.
   Results There was no statistically significant difference in the prevalence of MetS and CRP values between the studied groups. Waist circumference and total cholesterol levels were significantly higher in the experimental group. Patients that fulfilled the criteria for MetS showed significantly higher values of central obesity and arterial hypertension in the experimental group as well. The elevated CRP levels were associated with increased frequency of MetS in depressed patients.
   Conclusion Both CRP levels and metabolic risk profile screening, according to the international criteria, may be beneficial in order to obtain better assessment for depressive long term medicated patients.
C1 [Stanojevic, Albina; Popovic, Irena] Special Hosp Mental Disorders Gornja Topon, Nish, Serbia.
   [Nenadovic, Milutin] Special Hosp Mental Disorders Laza Lazarev, Belgrade, Serbia.
   [Nenadovic, Milutin] Univ Pristina, Fac Med, Kosovska Mitrovica, Serbia.
   [Ravanic, Dragan] Univ Kragujevac, Dept Psychiat, Kragujevac, Serbia.
C3 Universiteti i Prishtines; University of Kragujevac
RP Popovic, I (corresponding author), Specialized Hosp Psychiat Disorders Gornja Topon, Gornja Toponica 18202, Serbia.
EM ipopovic69@yahoo.com
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NR 28
TC 4
Z9 5
U1 0
U2 5
PU SRPSKO LEKARSKO DRUSTVO
PI BEOGRAD
PA UREDNISTVO CASOPISA SRPSKI ARHIV, UL DZORDZA VASINGTONA 19, BEOGRAD,
   11000, SERBIA
SN 0370-8179
J9 SRP ARK CELOK LEK
JI Srp. Ark. Celok. Lek.
PD JUL-AUG
PY 2013
VL 141
IS 7-8
BP 511
EP 515
DI 10.2298/SARH1308511S
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 230YZ
UT WOS:000325381500013
PM 24073559
OA gold
DA 2025-06-11
ER

PT J
AU Happell, B
   Platania-Phung, C
   Gray, R
   Hardy, S
   Lambert, T
   Mcallister, M
   Davies, C
AF Happell, B.
   Platania-Phung, C.
   Gray, R.
   Hardy, S.
   Lambert, T.
   Mcallister, M.
   Davies, C.
TI A role for mental health nursing in the physical health care of
   consumers with severe mental illness
SO JOURNAL OF PSYCHIATRIC AND MENTAL HEALTH NURSING
LA English
DT Article
DE comorbidity; mental health nursing; physical care screening; severe
   mental illness
ID AUSTRALIAN PSYCHIATRIC-PATIENTS; CATIE SCHIZOPHRENIA TRIAL; METABOLIC
   SYNDROME; HEPATITIS-C; MORTALITY; PREVALENCE; OBESITY; STIGMA;
   INDIVIDUALS; DEPRESSION
AB There is extensive international evidence that people with severe mental illness have a lower standard of physical health than the general population. This leads to higher morbidity and mortality rates. Many of the causes for this poor physical health are modifiable. Yet the physical needs of this consumer group are neglected by healthcare systems in Australia, and elsewhere. While medical specialists are clearly integral to remedying this, nurses are well placed to play a key role in focused prevention and early intervention in the physical well-being of consumers with mental health problems. This paper outlines the specifics on how mental health nurses can be sensitized, prepared and empowered to help turn this serious health issue around. In particular, mental health nurses could be trained in and then utilize a new physical health check and response system in the UK (called the Health Improvement Profile) if adapted for use within Australia. This profile will be briefly introduced, and then its value to improving health care discussed.
C1 [Happell, B.; Platania-Phung, C.] CQUniv Australia, Sch Nursing & Midwifery, Inst Hlth & Social Sci Res, Rockhampton, Qld 4702, Australia.
   [Mcallister, M.] Univ Sunshine Coast, Fac Sci Hlth & Educ, Brisbane, Qld, Australia.
   [Lambert, T.] Univ Sydney, Concord Med Sch, Sydney, NSW 2006, Australia.
   [Lambert, T.] Univ Sydney, Brain & Mind Res Inst, Sydney, NSW 2006, Australia.
   [Gray, R.] Univ E Anglia, Fac Hlth, Norwich NR4 7TJ, Norfolk, England.
   [Hardy, S.] Univ E Anglia Nursing, Northamptonshire Teaching PrimaryCare Trust, PhyHWell Project, Norwich, Norfolk, England.
C3 Central Queensland University; University of the Sunshine Coast;
   University of Sydney; University of Sydney; University of East Anglia;
   University of East Anglia
RP Happell, B (corresponding author), CQUniv Australia, Sch Nursing & Midwifery, Inst Hlth & Social Sci Res, Rockhampton, Qld 4702, Australia.
EM b.happell@cqu.edu.au
RI ; Happell, Brenda/HSI-0570-2023; Gray, Richard/C-9945-2017
OI Jennings, Cally/0000-0001-9017-7077; Happell,
   Brenda/0000-0002-7293-6583; Gray, Richard/0000-0001-9694-4206;
   McAllister, Margaret/0000-0003-1181-1610
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NR 65
TC 47
Z9 51
U1 0
U2 20
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1351-0126
EI 1365-2850
J9 J PSYCHIATR MENT HLT
JI J. Psychiatr. Ment. Health Nurs.
PD OCT
PY 2011
VL 18
IS 8
BP 706
EP 711
DI 10.1111/j.1365-2850.2010.01666.x
PG 6
WC Nursing; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Psychiatry
GA 820KU
UT WOS:000294905400008
PM 21896113
DA 2025-06-11
ER

PT J
AU Jo, KJ
   Nam, GH
   Park, YS
   Kawk, HW
   Kim, JT
   Choi, WH
   Jang, SH
   Kim, MJ
   Kim, YM
AF Jo, Kyung Jo
   Nam, Gun He
   Park, Ye Seul
   Kawk, Hye Won
   Kim, Jong Tae
   Choi, Won Hee
   Jang, Seung Hee
   Kim, Min Jeong
   Kim, Young Min
TI Evaluation of Stress-related Behavioral and Biological Activity of
   Ocimum sanctum Extract in Rats
SO BIOTECHNOLOGY AND BIOPROCESS ENGINEERING
LA English
DT Article
DE Ocimum sanctum; restraint stress; sleep deprivation; anti-anxiety;
   hypothalamic pituitary adrenal axis (HPA axis); cortisol; AMPK; Glut4;
   Acetyl-CoA carboxylase (ACC); glucose metabolism; insulin resistance
ID ACTIVATED PROTEIN-KINASE; SHORT-SLEEP DURATION; MELATONIN SYNTHESIS;
   ELEVATED GHRELIN; REDUCED LEPTIN; PINEAL-GLAND; RISK-FACTOR; INSOMNIA;
   ANXIETY; ANTIDEPRESSANTS
AB Stress is an emerging and inevitable entity. Stress causes anxiety, depression, imbalance of homeostasis, hormone imbalance, and sleep disturbances that are closely related to the onset of metabolic syndrome. The objective of this study was to investigate effects of Ocimum sanctum extract (TZ-OSE) on anti-anxiety, anti-stress, and control of physiological changes due to sleep disturbance in a rat model with restraint stress and sleep disorder induced. After inducing the rat model with restraint stress, three behavioral tests were performed and blood cortisol concentration was determined. In Elevated plus maze test, the test substance TZ-OSE at dose of 200 mg/kg showed the best effect in increasing time that stayed on the open arms. In tail suspension test (TST) and forced swimming test (FST), TZ-OSE significantly reduced immobility duration time (IMT). TZ-OSE also decreased plasma cortisol concentration. In the model after inducing sleep disturbance, ELISA, Western blotting, and Immuno-histochemistry (IHC) were conducted. TZ-OSE treatment decreased plasma cortisol, norepinephrine, glucose, and acylated ghrelin concentrations in the rat model with sleep disorders induced. Decreases of melatonin and leptin levels in the plasma of the rat model with sleep disorders induced were increased by TZ-OSE treatment. Finally, TZ-OSE treatment decreased metabolism-related markers (p-AMPK, Glut-4, p-ACC) in stomach and muscle tissues and decreased the expression of cortisol in adrenal gland tissues. Taken together, these results suggest that TZ-OSE can decrease anxiety, depression, and stress in vivo, regulate sleep-related factors, and control energy metabolism index factors.
C1 [Jo, Kyung Jo; Nam, Gun He; Park, Ye Seul; Kawk, Hye Won; Kim, Young Min] Hannam Univ, Dept Biol Sci & Biotechnol, Daejeon 34054, South Korea.
   [Kim, Jong Tae; Choi, Won Hee; Jang, Seung Hee; Kim, Min Jeong] Teazen Co Ltd, Haenam 59017, South Korea.
C3 Hannam University
RP Kim, YM (corresponding author), Hannam Univ, Dept Biol Sci & Biotechnol, Daejeon 34054, South Korea.
EM kym@hnu.ac.kr
RI Kim, Young-Min/JLL-7158-2023
OI Nam, Gun He/0000-0002-7737-8947
FU Technology development Program - Ministry of SMEs and Startups (MSS,
   Korea) [S2449517]
FX This work was supported by the Technology development Program(S2449517)
   funded by the Ministry of SMEs and Startups (MSS, Korea).
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NR 57
TC 3
Z9 3
U1 1
U2 7
PU KOREAN SOC BIOTECHNOLOGY & BIOENGINEERING
PI SEOUL
PA KOREAN SCIENCE TECHNOLOGY CENTER, #704 YEOGSAM-DONG, KANGNAM-KU, SEOUL
   135-703, SOUTH KOREA
SN 1226-8372
EI 1976-3816
J9 BIOTECHNOL BIOPROC E
JI Biotechnol. Bioprocess Eng.
PD MAR
PY 2020
VL 25
IS 2
BP 170
EP 180
DI 10.1007/s12257-019-0365-2
EA APR 2020
PG 11
WC Biotechnology & Applied Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology
GA LI5QG
UT WOS:000526236500002
DA 2025-06-11
ER

PT J
AU Dickerson, SS
   Gruenewald, TL
   Kemeny, ME
AF Dickerson, SS
   Gruenewald, TL
   Kemeny, ME
TI When the social self is threatened: Shame, physiology, and health
SO JOURNAL OF PERSONALITY
LA English
DT Article
ID C-REACTIVE PROTEIN; NECROSIS-FACTOR-ALPHA; GLUCOCORTICOID RESISTANCE;
   PSYCHOLOGICAL STRESS; CYTOKINE PRODUCTION; METABOLIC SYNDROME; HIV
   PROGRESSION; DEPRESSION; GUILT; EMBARRASSMENT
AB Our program of research focuses on shame as a key emotional response to "social self" threats (i.e., social evaluation or rejection). We propose that shame may orchestrate specific patterns of psychobiological changes under these conditions. A series of studies demonstrates that acute threats to the social self increase proinflammatory cytokine activity and cortisol and that these changes occur in concert with shame. Chronic social self threats and persistent experience of shame-related cognitive and affective states predict disease-relevant immunological and health outcomes in HIV. Across our laboratory and longitudinal studies, general or composite affective states (e.g., distress) are unrelated to these physiological and health outcomes. These findings support a stressor- and emotional response-specificity model for psychobiological and health research.
C1 Univ Calif Los Angeles, Los Angeles, CA USA.
   Univ Calif San Francisco, San Francisco, CA 94143 USA.
C3 University of California System; University of California Los Angeles;
   University of California System; University of California San Francisco
RP Univ Calif Irvine, Dept Psychol & Social Behav, 3340 Social Ecol 2, Irvine, CA 92697 USA.
EM sdickers@uci.edu
RI Gruenewald, Tara/KLE-3300-2024
FU NIMH NIH HHS [MH42918] Funding Source: Medline
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NR 97
TC 512
Z9 689
U1 5
U2 122
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-3506
EI 1467-6494
J9 J PERS
JI J. Pers.
PD DEC
PY 2004
VL 72
IS 6
BP 1191
EP 1216
DI 10.1111/j.1467-6494.2004.00295.x
PG 26
WC Psychology, Social
WE Social Science Citation Index (SSCI)
SC Psychology
GA 866EJ
UT WOS:000224756300005
PM 15509281
DA 2025-06-11
ER

PT J
AU Kunugi, H
AF Kunugi, Hiroshi
TI Depression and lifestyle: Focusing on nutrition, exercise, and their
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SO PSYCHIATRY AND CLINICAL NEUROSCIENCES
LA English
DT Review
DE depression; diet; exercise; lifestyle; sleep
ID AMINO-ACID PROFILE; BODY-MASS INDEX; VITAMIN-D; METABOLIC SYNDROME;
   COGNITIVE FUNCTION; MENTAL-HEALTH; EICOSAPENTAENOIC ACID; NEUROTROPHIC
   FACTOR; TREATMENT OUTCOMES; MAJOR DEPRESSION
AB Accumulating evidence has suggested the important role of lifestyle factors in depressive disorder. This paper aimed to introduce and outline recent research on epidemiological and intervention studies on lifestyle-related factors in depressive disorder with a special focus on diet. Evidence on exercise, sleep. and related behaviors is also described. Here, findings from meta-analytic studies are emphasized and related studies by the author's research group are introduced. Dietary factors that increase the risk of the illness include energy overload, skipping breakfast, unhealthy diet styles such as Western diet, inflammation-prone diet, and high consumption of ultraprocessed food (UPF). Nutritional imbalances such as inadequate intake of protein, fish (omega 3 polyunsaturated fatty acids), vitamins (folate and vitamin D), and minerals (iron and zinc) increases the risk of depression. Poor oral hygiene, food allergy, addiction to alcohol, and smoking constitute risk factors. Sedentary lifestyle and increased screen time (e.g. video games and the internet) confer the risk of depression. Insomnia and disturbed sleep-wake rhythm are also involved in the pathogenesis of depression. There is accumulating evidence at the meta-analysis level for interventions to modify these lifestyle habits in the protection and treatment of depressive disorder. Main biological mechanisms of the link between lifestyle factors and depression include monoamine imbalance, inflammation, altered stress response, oxidative stress, and dysfunction of brain-derived neurotrophic factor, although other players such as insulin, leptin, and orexin also play a role. To increase resilience to modern stress and ameliorate depression through modification of lifestyle habits, a list of 30 recommendable interventions is presented.
C1 [Kunugi, Hiroshi] Teikyo Univ, Dept Psychiat, Sch Med, Tokyo, Japan.
C3 Teikyo University
RP Kunugi, H (corresponding author), Teikyo Univ, Dept Psychiat, Sch Med, Tokyo, Japan.
EM hkunugi@med.teikyo-u.ac.jp
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NR 220
TC 37
Z9 40
U1 8
U2 61
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1323-1316
EI 1440-1819
J9 PSYCHIAT CLIN NEUROS
JI Psychiatry Clin. Neurosci.
PD AUG
PY 2023
VL 77
IS 8
BP 420
EP 433
DI 10.1111/pcn.13551
EA APR 2023
PG 14
WC Clinical Neurology; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Psychiatry
GA O1HI0
UT WOS:000974734700001
PM 36992617
OA Green Accepted, hybrid
DA 2025-06-11
ER

PT J
AU Min, SH
   Yang, Q
   Docherty, SL
   Im, EO
   Hu, X
AF Min, Se Hee
   Yang, Qing
   Docherty, Sharron L.
   Im, Eun-Ok
   Hu, Xiao
TI Symptom Clusters and Key Symptoms Among Midlife Perimenopausal and
   Postmenopausal Women With and Without Metabolic Syndrome
SO NURSING RESEARCH
LA English
DT Article
DE menopause; obesity; quality of life; symptom management; women's health
ID MENOPAUSAL TRANSITION; NETWORK ANALYSIS; SEXUAL FUNCTION; PREVALENCE;
   ASSOCIATION; DYSFUNCTION; DEPRESSION; ANXIETY; COHORT; HEALTH
AB Background Midlife perimenopausal and postmenopausal women with metabolic syndrome experience multiple symptoms concurrently. Objective The study objectives were to examine the relationship among symptoms through network visualization and identify and compare symptom clusters and key symptoms across symptom occurrence and symptom severity dimensions in midlife perimenopausal and postmenopausal women with and without metabolic syndrome. Methods Cross-sectional data from the Study of Women's Health Across the Nation (Visit 5) were used for analysis. A machine-learning-based network analysis and the Walktrap algorithm were used to fulfill the study objectives. Results The number and types of symptom clusters differed between the groups. Midlife perimenopausal and postmenopausal women with metabolic syndrome experienced the psychological/somatic/genital cluster (key symptom: frequent mood change), the sleep/urinary cluster (sleep disturbance), and the vasomotor cluster (cold sweat) in the symptom occurrence dimension and the psychological/somatic/sexual cluster (anxiety), the sleep/urinary cluster (sleep disturbance), and the vasomotor/genital cluster (night sweat) in the symptom severity dimension. In contrast, midlife perimenopausal and postmenopausal women without metabolic syndrome experienced the psychological cluster (anxiety), the sleep/somatic/genitourinary cluster (sleep disturbance), and the vasomotor cluster (night sweat) in the symptom occurrence dimension and the psychological/somatic cluster (anxiety), the sleep/urinary cluster (sleep disturbance), the vasomotor cluster (night sweat), and the sexual/genital cluster (vaginal dryness) in the symptom severity dimension. Discussion The study findings may serve as a knowledge basis for effective assessment and management of symptom clusters and key symptoms in clinical settings and provide directions for future development of targeted symptom management interventions.
C1 [Min, Se Hee; Yang, Qing; Docherty, Sharron L.] Duke Univ, Sch Nursing, 370 Trent Dr, Durham, NC 27705 USA.
   [Im, Eun-Ok; Hu, Xiao] Emory Univ, Sch Nursing, Atlanta, GA 30322 USA.
C3 Duke University; Emory University
RP Min, SH (corresponding author), Duke Univ, Sch Nursing, 370 Trent Dr, Durham, NC 27705 USA.
EM sehee.min@duke.edu; qing.yang@duke.edu; sharron.docherty@duke.edu;
   eun.ok.im@emory.edu; xiao.hu@duke.edu
RI Hu, Xiaoyu/AAO-2060-2020
OI Min, Se Hee/0000-0003-2722-6627; Yang, Qing/0000-0003-4844-4690
FU National Institute of Nursing Research of the National Institutes of
   Health [1F31NR019921-01]
FX Research reported in this publication was supported by the National
   Institute of Nursing Research of the National Institutes of Health under
   Award Number 1F31NR019921-01. The content is solely the authors'
   responsibility and does not necessarily represent the official views of
   the National Institutes of Health.
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NR 36
TC 9
Z9 11
U1 2
U2 22
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0029-6562
EI 1538-9847
J9 NURS RES
JI Nurs. Res.
PD JUL-AUG
PY 2022
VL 71
IS 4
BP E28
EP E38
DI 10.1097/NNR.0000000000000591
PG 11
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA 2J3FF
UT WOS:000815546700001
PM 35759720
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Hall, CV
   Hepsomali, P
   Dalile, B
   Scapozza, L
   Gurry, T
AF Hall, Caitlin Victoria
   Hepsomali, Piril
   Dalile, Boushra
   Scapozza, Leonardo
   Gurry, Thomas
TI Effects of a diverse prebiotic fibre blend on inflammation, the gut
   microbiota and affective symptoms in metabolic syndrome: a pilot
   open-label randomised controlled trial
SO BRITISH JOURNAL OF NUTRITION
LA English
DT Article
DE Microbiota-gut-brain axis; Depression; Anxiety; Stress; High sensitivity
   C-reactive protein; Inflammation; Prebiotic fibre
ID ANXIETY STRESS SCALES; C-REACTIVE PROTEIN; HEALTHY-ADULTS; DIETARY
   FIBER; DOUBLE-BLIND; FATTY-ACIDS; DEPRESSION; METAANALYSIS; ASSOCIATION;
   SICKNESS
AB Emerging evidence suggests that low-grade systemic inflammation plays a key role in altering brain activity, behaviour and affect. Modulation of the gut microbiota using prebiotic fibre offers a potential therapeutic tool to regulate inflammation, mediated via the production of short-chain fatty acids (SCFA). However, the impact of prebiotic consumption on affective symptoms and the possible contribution from inflammation, gut symptoms and the gut microbiome are currently underexamined. In this 12-week study, the effects of a diverse prebiotic blend on inflammation, gut microbiota profiles and affective symptoms in a population with metabolic syndrome (MetS) were examined. Sixty males and females with MetS meeting the criteria for MetS were randomised into a treatment group (n 40), receiving 10 g per day of a diverse prebiotic blend and healthy eating advice, and a control group (n 20), receiving healthy eating advice only. Our results showed a significant reduction in high sensitivity C-reactive protein (hs-CRP) in the treatment (-0<middle dot>58 [-9<middle dot>96 to-2<middle dot>63]) compared with control (0<middle dot>37 [-3<middle dot>64 to-3<middle dot>32]), alongside significant improvements in self-reported affective scores in the treatment compared with the control group. While there were no differences in relative abundance between groups at week 12, there was a significant increase from baseline to week 12 in fecal Bifidobacterium and Parabacteroides in the treatment group, both of which are recognised as SCFA producers. Multivariate regression analyses further revealed an association between gastrointestinal symptoms and hs-CRP with affective scores. Together, this study provides preliminary support for a diverse prebiotic blend for mood, stress and anxiety.
C1 [Hall, Caitlin Victoria; Gurry, Thomas] Myota Ltd, London, England.
   [Hepsomali, Piril] Univ Reading, Sch Psychol & Clin Language Sci, Reading, England.
   [Dalile, Boushra] Katholieke Univ Leuven, Fac Med, Translat Res Ctr Gastrointestinal Disorders TARGID, Dept Chron Dis & Metab, Leuven, Belgium.
   [Dalile, Boushra] Katholieke Univ Leuven, Leuven Brain Inst, Leuven, Belgium.
   [Dalile, Boushra] Katholieke Univ Leuven, Fac Psychol & Educ Sci, Lab Biol Psychol Brain & Cognit, Leuven, Belgium.
   [Scapozza, Leonardo; Gurry, Thomas] Univ Geneva, Sch Pharmaceut Sci, Pharmaceut Biochem Grp, Geneva, Switzerland.
C3 University of Reading; KU Leuven; KU Leuven; KU Leuven; University of
   Geneva
RP Hepsomali, P (corresponding author), Univ Reading, Sch Psychol & Clin Language Sci, Reading, England.
EM p.hepsomali@reading.ac.uk
RI Scapozza, Leonardo/W-5278-2018; Dalile, Boushra/AAM-4680-2020;
   Hepsomali, Piril/ABC-1260-2021
OI Twelves, John Luke/0009-0001-9137-9727
FU Myota GmbH
FX This project was sponsored and funded by Myota GmbH.
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NR 73
TC 3
Z9 3
U1 5
U2 7
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1145
EI 1475-2662
J9 BRIT J NUTR
JI Br. J. Nutr.
PD OCT 28
PY 2024
VL 132
IS 8
BP 1002
EP 1013
DI 10.1017/S0007114524002186
EA OCT 2024
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA N4N0B
UT WOS:001332679800001
PM 39411833
OA hybrid
DA 2025-06-11
ER

PT J
AU Jung, SJ
   Woo, HT
   Cho, S
   Park, K
   Jeong, S
   Lee, YJ
   Kang, D
   Shin, A
AF Jung, Sun Jae
   Woo, Hyung-Taek
   Cho, Sooyoung
   Park, Kyounghoon
   Jeong, Seokhun
   Lee, Yu Jin
   Kang, Daehee
   Shin, Aesun
TI Association between body size, weight change and depression: systematic
   review and meta-analysis
SO BRITISH JOURNAL OF PSYCHIATRY
LA English
DT Review
ID LOW-BIRTH-WEIGHT; POSTTRAUMATIC-STRESS-DISORDER; LIFE-STYLE FACTORS;
   7-YEAR FOLLOW-UP; MASS INDEX; METABOLIC SYNDROME; MAJOR DEPRESSION;
   MENTAL-HEALTH; SELF-ESTEEM; ADOLESCENT DEPRESSION
AB Background
   The association between body size, weight change and depression has not been systematically summarised, especially for individuals who are underweight.
   Aims
   To conduct a systematic review and a meta-analysis to examine the association between indices of body size, weight change and depression.
   Method
   A total of 183 studies were selected. Fully adjusted hazard ratios (HRs) or odds ratios (ORs) were extracted. A total of 76 studies contributed to data synthesis with a random-effect model, and subgroup analyses were conducted to evaluate the effect of potential moderators.
   Results
   In cohort studies, underweight at baseline increased the risk of subsequent depression (OR = 1.16, 95% Cl 1.08-1.24). Overweight (BMI 25-29.9 kg/m(2)) showed no statistically significant relationship with depression overall; however, the subgroup analyses found different results according to gender (men: OR = 0.84, 95% Cl 0.72-0.97, women: OR = 1.16, 95% Cl 1.07-1.25). In cross-sectional designs, obesity with BMI >40 kg/m(2) showed a greater pooled odds ratio than obesity with BMI >30 kg/m(2).
   Conclusions
   Both underweight and obesity increase the risk of depression. The association between overweight and depression differs by gender.
C1 [Jung, Sun Jae] Seoul Natl Univ, Coll Med, Dept Biomed Sci, Seoul, South Korea.
   [Woo, Hyung-Taek; Cho, Sooyoung; Park, Kyounghoon; Jeong, Seokhun; Shin, Aesun] Seoul Natl Univ, Coll Med, Dept Prevent Med, 103 Daehak Ro, Seoul 03080, South Korea.
   [Lee, Yu Jin] Seoul Natl Univ Hosp, Dept Psychiat, Seoul, South Korea.
   [Kang, Daehee] Seoul Natl Univ, Coll Med, Dept Prevent Med, Dept Biomed Sci, Seoul, South Korea.
   [Kang, Daehee; Shin, Aesun] Seoul Natl Univ, Canc Res Inst, Seoul, South Korea.
C3 Seoul National University (SNU); Seoul National University (SNU); Seoul
   National University (SNU); Seoul National University Hospital; Seoul
   National University (SNU); Seoul National University (SNU)
RP Shin, A (corresponding author), Seoul Natl Univ, Coll Med, Dept Prevent Med, 103 Daehak Ro, Seoul 03080, South Korea.
EM shinaesun@sun.ac.kr
RI Shin, Aesun/E-9145-2014; Kang, Dae/E-8631-2012; Jung, Sun/O-5372-2019;
   Jung, Sun Jae/D-5620-2011
OI Jung, Sun Jae/0000-0002-5194-7339; Kang, Daehee/0000-0003-4031-5878;
   Park, Kyounghoon/0000-0001-5800-917X
FU SNUH Research Fund [23-2015-0010]
FX This study was supported by grant 23-2015-0010 from the SNUH Research
   Fund.
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NR 206
TC 130
Z9 139
U1 0
U2 47
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1250
EI 1472-1465
J9 BRIT J PSYCHIAT
JI Br. J. Psychiatry
PD JUL
PY 2017
VL 211
IS 1
BP 14
EP +
DI 10.1192/bjp.bp.116.186726
PG 61
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA EZ3IL
UT WOS:000404604500006
PM 28428339
OA Bronze
DA 2025-06-11
ER

PT J
AU Tang, F
   Wang, GP
   Lian, Y
AF Tang, Fang
   Wang, Gangpu
   Lian, Ying
TI Association between anxiety and metabolic syndrome: A systematic review
   and meta-analysis of epidemiological studies
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Review
DE Epidemiological association; Anxiety; Metabolic syndrome
ID PITUITARY-ADRENAL AXIS; HEART-RATE-VARIABILITY; PHYSICAL CONDITIONS;
   DEPRESSION; HEALTH; COMORBIDITY; ANTIDEPRESSANTS; DISABILITY; DISORDERS;
   SYMPTOMS
AB Objective: Epidemiological studies have repeatedly investigated the association between anxiety and metabolic syndrome (MetS). However, the results have been inconsistent. We performed a meta-analysis of observational studies to summarize the evidence regarding the relation of anxiety and MetS risk.
   Methods: We performed a systematic literature search of all studies published in PubMed and EMBASE from its inception to June 2016. Cross-sectional and cohort studies that reported an association between the two conditions in adults were included. Data on prevalence, incidence, unadjusted or adjusted odds ratio (OR), and 95% CI were extracted or provided independently by the authors. Random effects model was used to report the pooled OR. The 12 statistic was used to assess heterogeneity. Egger's test and Begger's test were used to evaluate the publication bias.
   Results: The search yielded 18 cross-sectional studies and two cohort studies. The pooled finding from cross-sectional studies showed that anxiety had a significant positive association with MetS (OR 1.07, 95% CI 1.01-1.12), with moderate heterogeneity (I-2 = 45.7%, P = 0.018). Findings from two cohort studies indicated that the association between anxiety and MetS was insignificant.
   Conclusion: Our results suggest that there is an association between anxiety and MetS. In individuals with MetS anxiety should be detected and managed. Further prospective studies are needed to explore the bidirectional association between anxiety and MetS. (C) 2016 Elsevier Ltd. All rights reserved.
C1 [Tang, Fang] Shandong Univ, Qianfoshan Hosp, Hlth Management Ctr, Jinan, Peoples R China.
   [Wang, Gangpu] Fourth Hosp Jinan City, Dept Gen Surg, Jinan, Peoples R China.
   [Lian, Ying] Shandong Univ, Qianfoshan Hosp, Dept Case Adm, Jinan, Peoples R China.
C3 Shandong University; Shandong First Medical University & Shandong
   Academy of Medical Sciences; Shandong First Medical University &
   Shandong Academy of Medical Sciences; Shandong University
RP Lian, Y (corresponding author), Shandong Univ, Qianfoshan Hosp, Dept Case Adm, Jinan, Peoples R China.
EM lianying525@sina.com
FU Shandong provincial Natural Science Foundation [ZR2015HL102]; Department
   of Science and Technology of Shandong Province [2016GSF201075]
FX This work was supported by Shandong provincial Natural Science
   Foundation (ZR2015HL102) and Project of priority research from
   Department of Science and Technology of Shandong Province
   (2016GSF201075).
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NR 48
TC 73
Z9 75
U1 0
U2 17
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
EI 1873-3360
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD MAR
PY 2017
VL 77
BP 112
EP 121
DI 10.1016/j.psyneuen.2016.11.025
PG 10
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA EP4UJ
UT WOS:000397375100016
PM 28027497
DA 2025-06-11
ER

PT J
AU Marazziti, D
   Arone, A
   Palermo, S
   Annuzzi, E
   Cappellato, G
   Chiarantini, I
   Del Prete, L
   Dell'Osso, L
AF Marazziti, Donatella
   Arone, Alessandro
   Palermo, Stefania
   Annuzzi, Eric
   Cappellato, Gabriele
   Chiarantini, Ilaria
   Del Prete, Luca
   Dell'Osso, Liliana
TI THE WICKED RELATIONSHIP BETWEEN DEPRESSION AND METABOLIC SYNDROME
SO CLINICAL NEUROPSYCHIATRY
LA English
DT Review
DE major depressive disorder; metabolic syndrome; inflammation; cytokines;
   cardiovascular disease; diet
ID BIPOLAR DISORDER; OXIDATIVE STRESS; DIET QUALITY; SEROTONIN; RISK;
   INFLAMMATION; ASSOCIATION; OBESITY; DYSFUNCTION; MECHANISMS
AB Major depressive disorder (MDD) constitutes a challenge in the field of mental disorders, given its high prevalence in the general population and its impact on the quality of life, while representing a major burden of health worldwide. Currently, much interest in the pathophysiology of MMD is also directed towards disentangling the possible biological mechanisms shared with that medical condition known as metabolic syndrome (MeS) that is frequent in the general population and often comorbid with MDD.Therefore, the aim of this paper was to summarize the evidence on the relationships between depression and MeS, and to comment on the common factors and mediators present in these two conditions. For this reason, some of the main databases of scientific literature were accessed, and all the papers fulfilling the goal of this review were selected. The results demonstrated the existence of common pathways between depression and metabolic syndrome involving several mediators, such as inflammation, the hypothalamus-pituitary-adrenal axis, oxidative stress, platelet functions, coronary heart disease and peripheral hormones, thus requiring strict attention from the scientific community. Indeed, such pathways may be targeted in the near future in order to pave the way to new treatment options for these disorders.
C1 [Marazziti, Donatella; Arone, Alessandro; Palermo, Stefania; Annuzzi, Eric; Cappellato, Gabriele; Chiarantini, Ilaria; Del Prete, Luca; Dell'Osso, Liliana] Univ Pisa, Dept Clin & Expt Med, Sect Psychiat, Pisa, Italy.
   [Marazziti, Donatella] Unicamillus St Camillus Int Univ Med & Hlth Sci, Rome, Italy.
C3 University of Pisa
RP Marazziti, D (corresponding author), Univ Pisa, Dept Clin & Expt Med, Sect Psychiat, Pisa, Italy.; Marazziti, D (corresponding author), Unicamillus St Camillus Int Univ Med & Hlth Sci, Rome, Italy.
EM dmarazzi@psico.med.unipi.it
RI Del Prete, Luca/LSJ-4470-2024
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NR 77
TC 8
Z9 9
U1 1
U2 1
PU GIOVANNI FIORITI EDITORE
PI ROME
PA VIA ARCHIMEDE 179, ROME, 00197, ITALY
SN 1724-4935
EI 2385-0787
J9 CLIN NEUROPSYCHIATR
JI Clin. Neuropsychiatr.
PD APR
PY 2023
VL 20
IS 2
BP 100
EP 108
DI 10.36131/cnfioritieditore20230202
PG 9
WC Clinical Neurology; Psychiatry
WE Emerging Sources Citation Index (ESCI)
SC Neurosciences & Neurology; Psychiatry
GA O3KO1
UT WOS:001042841600002
PM 37234360
DA 2025-06-11
ER

PT J
AU Bouglé, D
   Bouhallab, S
   Bureau, F
   Zunquin, G
AF Bougle, Dominique
   Bouhallab, Said
   Bureau, Francois
   Zunquin, Gautier
TI Effects of trace elements and calcium on diabetes and obesity, and their
   complications: Protective effect of dairy products - A mini-review
SO DAIRY SCIENCE & TECHNOLOGY
LA English
DT Article; Proceedings Paper
CT IDF/INRA 1st International Symposium on Minerals and Dairy Products
CY OCT 01-03, 2008
CL French Res Inst, Saint Malo, FRANCE
SP Dairy Federat
HO French Res Inst
DE calcium; trace element; iron; obesity; diabetes; peroxidation
ID INSULIN-RESISTANCE SYNDROME; IRON-DEFICIENCY; METABOLIC SYNDROME;
   CONSUMPTION; PREVALENCE; CHILDREN; STRESS; MECHANISMS; OVERWEIGHT;
   CHROMIUM
AB Trace elements and minerals influence the pathogenesis of obesity and diabetes and their complications, mainly through their involvement in peroxidation and inflammation. On the other hand, peroxidation and inflammation are liable to alter the metabolism of these nutrients, which should be taken into account when assessing their status. Milk products are capable of preventing iron-induced peroxidation and the metabolic complications of the diseases. Calcium, especially cow milk calcium, seems to be capable of preventing the development of adipocytes and obesity complications (inflammation, hypertension, and insulin resistance), mainly through interactions with vitamin D metabolism. These observations give an opportunity to influence the course of obesity by dietetic advices.
C1 [Bougle, Dominique; Bouhallab, Said; Bureau, Francois; Zunquin, Gautier] CH Bayeux, Ctr Educat Therapeut, Serv Pediat, F-14401 Bayeux, France.
RP Bouglé, D (corresponding author), CH Bayeux, Ctr Educat Therapeut, Serv Pediat, F-14401 Bayeux, France.
EM dbougle@wanadoo.fr
OI Bouhallab, Said/0000-0002-2679-0667
CR Azadbakht L, 2005, AM J CLIN NUTR, V82, P523, DOI 10.1093/ajcn/82.3.523
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NR 28
TC 6
Z9 6
U1 0
U2 9
PU SPRINGER FRANCE
PI PARIS
PA 22 RUE DE PALESTRO, PARIS, 75002, FRANCE
SN 1958-5586
EI 1958-5594
J9 DAIRY SCI TECHNOL
JI Dairy Sci. Technol.
PD MAY-AUG
PY 2009
VL 89
IS 3-4
BP 213
EP 218
DI 10.1051/dst/2009010
PG 6
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Food Science & Technology
GA 459GV
UT WOS:000267090500002
DA 2025-06-11
ER

PT J
AU Opsasnick, LA
   Zhao, W
   Ratliff, SM
   Du, JC
   Faul, JD
   Schmitz, LL
   Zhou, X
   Needham, BL
   Smith, JA
AF Opsasnick, Lauren A.
   Zhao, Wei
   Ratliff, Scott M.
   Du, Jiacong
   Faul, Jessica D.
   Schmitz, Lauren L.
   Zhou, Xiang
   Needham, Belinda L.
   Smith, Jennifer A.
TI Epigenome-wide mediation analysis of the relationship between
   psychosocial stress and cardiometabolic risk factors in the Health and
   Retirement Study (HRS)
SO CLINICAL EPIGENETICS
LA English
DT Article
DE Social epigenomics; Psychosocial stress; Cardiometabolic risk factors;
   Cardiovascular disease; Epigenome-wide mediation analysis; DNA
   methylation
ID BODY-MASS INDEX; DNA METHYLATION; R PACKAGE; ASSOCIATION; LOCI; DISEASE;
   GENES; IDENTIFICATION; INFLAMMATION; EPIGENETICS
AB BackgroundExposure to psychosocial stress is linked to a variety of negative health outcomes, including cardiovascular disease and its cardiometabolic risk factors. DNA methylation has been associated with both psychosocial stress and cardiometabolic disease; however, little is known about the mediating role of DNA methylation on the association between stress and cardiometabolic risk. Thus, using the high-dimensional mediation testing method, we conducted an epigenome-wide mediation analysis of the relationship between psychosocial stress and ten cardiometabolic risk factors in a multi-racial/ethnic population of older adults (n = 2668) from the Health and Retirement Study (mean age = 70.4 years).ResultsA total of 50, 46, 7, and 12 CpG sites across the epigenome mediated the total effects of stress on body mass index, waist circumference, high-density lipoprotein cholesterol, and C-reactive protein, respectively. When reducing the dimensionality of the CpG mediators to their top 10 uncorrelated principal components (PC), the cumulative effect of the PCs explained between 35.8 and 46.3% of these associations.ConclusionsA subset of the mediating CpG sites were associated with the expression of genes enriched in pathways related to cytokine binding and receptor activity, as well as neuron development. Findings from this study help to elucidate the underlying mechanisms through which DNA methylation partially mediates the relationship between psychosocial stress and cardiometabolic risk factors.
C1 [Opsasnick, Lauren A.; Zhao, Wei; Ratliff, Scott M.; Needham, Belinda L.; Smith, Jennifer A.] Univ Michigan, Sch Publ Hlth, Dept Epidemiol, 1415 Washington Hts, Ann Arbor, MI 48109 USA.
   [Zhao, Wei; Faul, Jessica D.; Smith, Jennifer A.] Univ Michigan, Inst Social Res, Survey Res Ctr, Ann Arbor, MI USA.
   [Du, Jiacong; Zhou, Xiang] Univ Michigan, Sch Publ Hlth, Dept Biostat, Ann Arbor, MI USA.
   [Schmitz, Lauren L.] Univ Wisconsin Madison, Robert M La Follette Sch Publ Affairs, Madison, WI USA.
C3 University of Michigan System; University of Michigan; University of
   Michigan System; University of Michigan; University of Michigan System;
   University of Michigan; University of Wisconsin System; University of
   Wisconsin Madison
RP Opsasnick, LA (corresponding author), Univ Michigan, Sch Publ Hlth, Dept Epidemiol, 1415 Washington Hts, Ann Arbor, MI 48109 USA.
EM opsasnic@umich.edu
RI Smith, Albert Vernon/AHC-3838-2022
OI Smith, Jennifer Ann/0000-0002-3575-5468
FU National Human Genome Research Institute
FX Not applicable.
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NR 106
TC 2
Z9 2
U1 3
U2 3
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1868-7075
EI 1868-7083
J9 CLIN EPIGENETICS
JI Clin. Epigenetics
PD DEC 18
PY 2024
VL 16
IS 1
AR 180
DI 10.1186/s13148-024-01799-4
PG 16
WC Oncology; Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Genetics & Heredity
GA P9D9S
UT WOS:001380836200001
PM 39695878
OA gold
DA 2025-06-11
ER

PT J
AU Novak, JR
   Robinson, LP
   Korn, LE
AF Novak, Josh R.
   Robinson, Lindsey P.
   Korn, Leslie E.
TI What MFTs should know about nutrition, psychosocial health, and
   collaborative care with nutrition professionals
SO JOURNAL OF MARITAL AND FAMILY THERAPY
LA English
DT Article
DE assessment; collaborative care; diet; mental health; nutrition;
   treatment
ID SOCIAL SUPPORT; EMOTION SUPPRESSION; METABOLIC SYNDROME;
   SELF-MANAGEMENT; WEIGHT-LOSS; DEPRESSION; BEHAVIOR; MODEL; DIET;
   ASSOCIATION
AB Despite sufficient evidence on the role of nutrition in psychosocial health, Marriage and Family Therapists lack the knowledge for sufficient assessment and referrals in treatment. The purpose of this article is to orient MFTs to human metabolism and the effects of various nutrients, or lack thereof, on the psychosocial health in their clients. The roles of several micronutrients and macronutrients will be described as well as the effects of eating patterns and overall metabolic health on mental health. Finally, implications for MFTs as sole practitioners, domains for assessment and psychoeducation, and recommendations for collaborating with nutrition professionals will be discussed.
C1 [Novak, Josh R.; Robinson, Lindsey P.; Korn, Leslie E.] Auburn Univ, Dept Human Dev & Family Sci, Auburn, AL 36849 USA.
C3 Auburn University System; Auburn University
RP Novak, JR (corresponding author), Glanton House,312 Quad Dr, Auburn, AL 36832 USA.
EM jrn0031@auburn.edu
OI Novak, Joshua/0000-0002-9714-1226
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NR 103
TC 1
Z9 2
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0194-472X
EI 1752-0606
J9 J MARITAL FAM THER
JI J. Marital Fam. Ther.
PD APR
PY 2022
VL 48
IS 2
BP 502
EP 522
DI 10.1111/jmft.12540
EA JUL 2021
PG 21
WC Psychology, Clinical; Family Studies
WE Social Science Citation Index (SSCI)
SC Psychology; Family Studies
GA 0N3HM
UT WOS:000673659600001
PM 34264531
DA 2025-06-11
ER

PT J
AU Konstantinidou, SK
   Argyrakopoulou, G
   Tentolouris, N
   Karalis, V
   Kokkinos, A
AF Konstantinidou, Sofia K.
   Argyrakopoulou, Georgia
   Tentolouris, Nicholas
   Karalis, Vangelis
   Kokkinos, Alexander
TI Interplay between baroreflex sensitivity, obesity and related
   cardiometabolic risk factors (Review)
SO EXPERIMENTAL AND THERAPEUTIC MEDICINE
LA English
DT Review
DE BRS; obesity; autonomic disorders; blood pressure regulation; metabolic
   syndrome
ID SYMPATHETIC-NERVE ACTIVITY; TYPE-2 DIABETES-MELLITUS; BLOOD-PRESSURE;
   SYMPATHOVAGAL IMBALANCE; AUTONOMIC REGULATION; RESISTANCE EXERCISE;
   METABOLIC SYNDROME; BARIATRIC SURGERY; RECEPTOR GENE; WEIGHT-LOSS
AB The baroreflex represents a rapid negative feedback system implicated in blood pressure regulation, which aims to prevent blood pressure variations by regulating peripheral vascular tone and cardiac output. The aim of the present review was to highlight the association between baroreflex sensitivity (BRS) and obesity, including factors associated with obesity, such as metabolic syndrome, hypertension, cardiovascular disease and diabetes. For the present review, a literature search was conducted using the PubMed database until August 21, 2021. The searched terms included 'baroreflex', and other terms such as 'sensitivity', 'obesity', 'metabolic syndrome', 'hypertension', 'diabetes', 'gender', 'aging', 'children', 'adolescents', 'physical activity', 'bariatric surgery', 'autonomous nervous system' and 'cardiometabolic risk factors'. Obesity and its related metabolic disorders can influence baroreflex functionality and decrease BRS, mostly by potentiating sympathetic nervous system activity. Obesity induces inflammation, which can increase sympathetic system activity and lead to a higher incidence of cardiovascular events. Obesity also represents an important risk factor for hypertension through numerous mechanisms; in this setting, dysfunctional baroreceptors are not able to protect against constantly elevated blood pressure. Furthermore, diabetes mellitus and oxidative stress result in deterioration of BRS, whereas aging is also generally related to reduced cardiovagal BRS. Differences in BRS have also been observed between men and women, and overall cardiovagal BRS in healthy women is less intense compared with that in men. BRS appears lower in children with obesity compared with that in children of a healthy weight. Notably, physical exercise can increase BRS in both hypertensive and normotensive subjects, and BRS can also be significantly improved following bariatric surgery and weight loss. In conclusion, obesity and its related metabolic disorders may influence baroreflex functionality and decrease BRS, and baroreceptors cannot protect against the constantly elevated blood pressure in obesity. However, following bariatric surgery and weight loss, BRS can be significantly improved. The present review summarizes the role of obesity and related metabolic risk factors in BRS, providing details on possible mechanisms and shedding light on their interplay leading to autonomic neuropathy.
C1 [Konstantinidou, Sofia K.; Tentolouris, Nicholas; Kokkinos, Alexander] Natl & Kapodistrian Univ Athens, Sch Med, Laiko Gen Hosp, Dept Propaedeut Internal Med 1, 17 Aghiou Thoma, Athens 11527, Greece.
   [Konstantinidou, Sofia K.; Argyrakopoulou, Georgia] Athens Med Ctr, Diabet & Obes Unit, Athens 15125, Greece.
   [Karalis, Vangelis] Natl & Kapodistrian Univ Athens, Sch Hlth Sci, Dept Pharm, Athens 15784, Greece.
C3 National & Kapodistrian University of Athens; Laiko General Hospital;
   Athens Medical School; National & Kapodistrian University of Athens
RP Konstantinidou, SK (corresponding author), Natl & Kapodistrian Univ Athens, Sch Med, Laiko Gen Hosp, Dept Propaedeut Internal Med 1, 17 Aghiou Thoma, Athens 11527, Greece.
EM sofiakon@med.uoa.gr
RI Karalis, Vangelis/L-9642-2019; Argyrakopoulou, Georgia/AAT-6172-2021;
   Konstantinidou, Sofia/JVM-9062-2024; Kokkinos, A/K-6345-2019
OI Argyrakopoulou, Georgia/0000-0001-5502-565X
FU Onassis Foundation [G ZO 011-1/2018-2019]
FX The present study was supported by the Onassis Foundation (grant no. G
   ZO 011-1/2018-2019).
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NR 102
TC 9
Z9 9
U1 0
U2 4
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1792-0981
EI 1792-1015
J9 EXP THER MED
JI Exp. Ther. Med.
PD JAN
PY 2022
VL 23
IS 1
AR 67
DI 10.3892/etm.2021.10990
PG 13
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA XL3DI
UT WOS:000728027300001
PM 34934438
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Zhan, LY
   Yin, HM
   Gao, YJ
   Li, Y
   Ma, J
AF Zhan, Luyu
   Yin, Huimin
   Gao, Yujun
   Li, Yi
   Ma, Jun
TI Prevalence and Factors Associated with Subclinical Hypothyroidism in
   Major Depressive Disorder Patients with Dyslipidemia
SO NEUROPSYCHIATRIC DISEASE AND TREATMENT
LA English
DT Article
DE major depressive disorder; prevalence; dyslipidemia; subclinical
   hypothyroidism
ID METABOLIC SYNDROME; POPULATION; RISK
AB Background: Major depressive disorder (MDD) is a common psychiatric disorder with a high prevalence of comorbidity with subclinical hypothyroidism. The aim of this study was to investigate the prevalence and factors influencing the comorbidity of subclinical hypothyroidism in patients with dyslipidemic MDD who were hospitalized for the first time in a Chinese population. Methods: The study incorporated 708 first-time hospitalized MDD patients, all with dyslipidemia. Data collection encompassed socio-demographic information, blood pressure, fasting blood glucose (FBG), lipid, and thyroid hormone levels. Participants were evaluated using the Hamilton Depression Scale (HAMD), Hamilton Anxiety Scale (HAMA), and Positive Symptom Subscale (PSS). Results: The prevalence of subclinical hypothyroidism in dyslipidemic MDD patients with the first hospitalization was 39.97%. The course of the disease, age at onset, HAMA score, and low-density lipoprotein cholesterol (LDL-C) were risk factors for subclinical hypothyroidism in dyslipidemic MDD patients. The course of disease, age at onset, HAMA score, HAMD score, FBG, and systolic blood pressure (SBP) levels were observed to influence serum Thyroid Stimulating Hormone (TSH) levels.Conclusion: MDD patients with dyslipidemia have a high prevalence of subclinical hypothyroidism, and the outcome is associated with anxiety, fasting glucose, and lipids. This study provides a potential biomarker for the identification of co-morbid subclinical hypothyroidism in MDD patients with dyslipidaemia.
C1 [Zhan, Luyu; Yin, Huimin; Li, Yi; Ma, Jun] Anhui Med Univ, Sch Mental Hlth & Psychol Sci, Wuhan Mental Hlth Ctr, Wuhan, Peoples R China.
   [Gao, Yujun; Ma, Jun] Wuhan Mental Hlth Ctr, Dept Psychiat, Wuhan, Peoples R China.
   [Li, Yi; Ma, Jun] Wuhan Univ, Renmin Hosp, Dept Psychiat, Wuhan, Peoples R China.
   [Li, Yi; Ma, Jun] Wuhan Mental Hlth Ctr, 89 Gongnongbing Rd, Wuhan 430012, Hubei, Peoples R China.
C3 Anhui Medical University; Wuhan University
RP Li, Y; Ma, J (corresponding author), Anhui Med Univ, Sch Mental Hlth & Psychol Sci, Wuhan Mental Hlth Ctr, Wuhan, Peoples R China.; Li, Y; Ma, J (corresponding author), Wuhan Mental Hlth Ctr, 89 Gongnongbing Rd, Wuhan 430012, Hubei, Peoples R China.
EM psylee@163.com; majun0313@msn.cn
RI Ma, Jun/HLV-7600-2023
OI Ma, Jun/0000-0001-5633-6839
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NR 52
TC 6
Z9 6
U1 2
U2 7
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
EI 1178-2021
J9 NEUROPSYCH DIS TREAT
JI Neuropsychiatr. Dis. Treat.
PY 2023
VL 19
BP 2309
EP 2318
DI 10.2147/NDT.S435138
PG 10
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Psychiatry
GA X8RN2
UT WOS:001101057900001
PM 37920820
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Zamora, M
   Sabado-Liwag, M
AF Zamora, Mayra
   Sabado-Liwag, Melanie
TI Mental Health and PCOS Information-Sharing: Interviews with Health Care
   Providers in a Low-Income Urban Community
SO JOURNAL OF RACIAL AND ETHNIC HEALTH DISPARITIES
LA English
DT Article
DE Polycystic ovary syndrome; Mental health; Hispanics; Latinas;
   Information-sharing; Healthcare delivery
ID POLYCYSTIC-OVARY-SYNDROME; QUALITY-OF-LIFE; PSYCHOLOGICAL DISTRESS;
   METABOLIC SYNDROME; WOMEN; DEPRESSION; PREVALENCE; PHYSICIANS;
   KNOWLEDGE; SYMPTOMS
AB Polycystic ovary syndrome (PCOS) is a female metabolic-endocrine disorder typically characterized by menstrual dysfunction, hyperandrogenism, and/or polycystic ovaries. While comorbidity with poor mental health is often observed, it is less understood if women of color are given information on PCOS, mental health, or both by healthcare providers. This paper examines the information-sharing practices of healthcare providers serving a low-income, predominantly Latino/Hispanic municipality in Southeast Los Angeles, CA. Of 65 providers identified across 27 clinics in the service area, four participated in one-on-one semi-structured interviews. Four themes relating to PCOS and mental health information were identified using content analysis. Results suggest that information-sharing on PCOS is limited to symptomatic patients and varies by provider specialization. Poor mental health as a side effect of PCOS is not elaborated on during patient-provider interactions within the explored service area. Implications and directions for further research are discussed, including mixed methods approaches for contextual information on PCOS among women of color and recommendations for improving communication among healthcare providers.
C1 [Zamora, Mayra; Sabado-Liwag, Melanie] Calif State Univ Los Angeles, Dept Publ Hlth, Los Angeles, CA 90032 USA.
C3 Los Angeles County Department of Public Health; California State
   University System; California State University Los Angeles
RP Sabado-Liwag, M (corresponding author), Calif State Univ Los Angeles, Dept Publ Hlth, Los Angeles, CA 90032 USA.
EM msabado@calstatela.edu
OI Sabado-Liwag, Melanie D./0000-0001-8026-7212
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NR 44
TC 1
Z9 1
U1 3
U2 9
PU SPRINGER INT PUBL AG
PI CHAM
PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND
SN 2197-3792
EI 2196-8837
J9 J RACIAL ETHN HEALTH
JI J. Racial Ethn. Health Disparities
PD JUN
PY 2023
VL 10
IS 3
BP 1086
EP 1095
DI 10.1007/s40615-022-01295-6
EA MAY 2022
PG 10
WC Public, Environmental & Occupational Health
WE Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA F8ND3
UT WOS:000792556200001
PM 35534681
DA 2025-06-11
ER

PT J
AU Li, RQ
   Zhan, WQ
   Huang, X
   Liu, Z
   Lv, SS
   Wang, JQ
   Liang, LY
   Ma, YX
AF Li, Ruiqiang
   Zhan, Wenqiang
   Huang, Xin
   Liu, Zhan
   Lv, Shuaishuai
   Wang, Jiaqi
   Liang, Luyao
   Ma, Yuxia
TI Association of Dietary Inflammatory Index (DII) and Depressive Disorders
SO JOURNAL OF INFLAMMATION RESEARCH
LA English
DT Review
DE dietary inflammatory index; depressive disorders; inflammation
ID STOP HYPERTENSION DASH; HEALTHY EATING INDEX; MEDITERRANEAN DIET;
   OLDER-ADULTS; METABOLIC SYNDROME; COGNITIVE DECLINE; PHYSICAL-ACTIVITY;
   OXIDATIVE STRESS; NATIONAL-HEALTH; MENTAL-HEALTH
AB A lot of evidence shows that inflammation is related to the development of depression. However, the heterogeneity of depression hinders efforts to understand, prevent and treat this disease. The purpose of this comprehensive review is to summarize the links between inflammation and the established core features of depression, which show more homogeneity than the syndrome itself: overreaction to negative information, changes in reward processing, and cognitive control decline, and somatic syndrome. For each core feature, we first briefly outline its relevance to depression and neurobiological basis, and then review the evidence to investigate the potential role of inflammation. We mainly focus on the discovery of the experimental paradigm of exogenous inflammation. We concluded that inflammation may play a role in overreaction to negative information, altered reward responses, and physical symptoms. There is less evidence to support the effect of inflammation on cognitive control by standard neuropsychological measures. Finally, we discussed the implications for future research and recommendations on how to test the role of inflammation in the pathogenesis of heterogeneous mental illness.
C1 [Li, Ruiqiang; Huang, Xin; Liu, Zhan; Lv, Shuaishuai; Wang, Jiaqi; Liang, Luyao; Ma, Yuxia] Hebei Med Univ, Sch Publ Hlth, Hebei Prov Key Lab Environm & Human Hlth, Dept Nutr & Food Hyg, Shijiazhuang, Hebei, Peoples R China.
   [Zhan, Wenqiang] Shanghai Jiao Tong Univ, Sch Publ Hlth, Sch Med, Shanghai 200025, Peoples R China.
C3 Hebei Medical University; Shanghai Jiao Tong University
RP Ma, YX (corresponding author), Hebei Med Univ, Sch Publ Hlth, Hebei Prov Key Lab Environm & Human Hlth, Dept Nutr & Food Hyg, Shijiazhuang, Hebei, Peoples R China.
EM mayuxia@hebmu.edu.cn
RI Wang, Xianlong/AFU-4519-2022
FU  [2017YFC0907701]
FX Community Cohort Study on Specialized Nervous System Diseases
   (No.2017YFC0907701).
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NR 125
TC 10
Z9 10
U1 4
U2 21
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
EI 1178-7031
J9 J INFLAMM RES
JI J. Inflamm. Res.
PY 2021
VL 14
BP 6959
EP 6973
DI 10.2147/JIR.S344002
PG 15
WC Immunology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Immunology
GA XU1WN
UT WOS:000734064400001
PM 34949933
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Proeschold-Bell, RJ
   Turner, EL
   Bennett, GG
   Yao, J
   Li, XF
   Eagle, DE
   Meyer, RA
   Williams, RB
   Swift, RY
   Moore, HE
   Kolkin, MA
   Weisner, CC
   Rugani, KM
   Hough, HJ
   Williams, VP
   Toole, DC
AF Proeschold-Bell, Rae Jean
   Turner, Elizabeth L.
   Bennett, Gary G.
   Yao, Jia
   Li, Xiang-Fang
   Eagle, David E.
   Meyer, Rachel A.
   Williams, Redford B.
   Swift, Robin Y.
   Moore, H. Edgar
   Kolkin, Melanie A.
   Weisner, Carl C.
   Rugani, Katherine M.
   Hough, Holly J.
   Williams, Virginia P.
   Toole, David C.
TI A 2-Year Holistic Health and Stress Intervention: Results of an RCT in
   Clergy
SO AMERICAN JOURNAL OF PREVENTIVE MEDICINE
LA English
DT Article
ID WEIGHT-LOSS; METABOLIC SYNDROME; CLINICAL-TRIALS; HIGH-RATES; RISK;
   OBESITY; METAANALYSIS; OVERWEIGHT; DEPRESSION; MANAGEMENT
AB Introduction: This study sought to determine the effect of a 2-year, multicomponent health intervention (Spirited Life) targeting metabolic syndrome and stress simultaneously.
   Design: An RCT using a three-cohort multiple baseline design was conducted in 2010-2014.
   Setting/participants: Participants were United Methodist clergy in North Carolina, U. S., in 2010, invited based on occupational status. Of invited 1,745 clergy, 1,114 consented, provided baseline data, and were randomly assigned to immediate intervention (n = 395), 1-year waitlist (n = 283), or 2-year waitlist (n = 436) cohorts for a 48-month trial duration.
   Intervention: The 2-year intervention consisted of personal goal setting and encouragement to engage in monthly health coaching, an online weight loss intervention, a small grant, and three workshops delivering stress management and theological content supporting healthy behaviors. Participants were not blinded to intervention.
   Main outcome measures: Trial outcomes were metabolic syndrome (primary) and self-reported stress and depressive symptoms (secondary). Intervention effects were estimated in 2016 in an intention-to-treat framework using generalized estimating equations with adjustment for baseline level of the outcome and follow-up time points. Log-link Poisson generalized estimating equations with robust SEs was used to estimate prevalence ratios (PRs) for binary outcomes; mean differences were used for continuous/score outcomes.
   Results: Baseline prevalence of metabolic syndrome was 50.9% and depression was 11.4%. The 12-month intervention effect showed a benefit for metabolic syndrome (PR = 0.86, 95% CI = 0.79, 0.94, p<0.001). This benefit was sustained at 24 months of intervention (PR = 0.88; 95% CI = 0.78, 1.00, p = 0.04). There was no significant effect on depression or stress scores.
   Conclusions: The Spirited Life intervention improved metabolic syndrome prevalence in a population of U. S. Christian clergy and sustained improvements during 24 months of intervention. These findings offer support for long-duration behavior change interventions and population-level interventions that allow participants to set their own health goals.
C1 [Proeschold-Bell, Rae Jean; Yao, Jia; Eagle, David E.] Duke Ctr Hlth Policy & Inequal Res, Duke Global Hlth Inst, Box 90392, Durham, NC 27708 USA.
   [Turner, Elizabeth L.] Duke Univ, Dept Biostat & Bioinformat, Durham, NC USA.
   [Turner, Elizabeth L.; Bennett, Gary G.; Toole, David C.] Duke Univ, Duke Global Hlth Inst, Durham, NC USA.
   [Bennett, Gary G.; Williams, Redford B.] Duke Univ, Dept Psychol & Neurosci, Durham, NC USA.
   [Li, Xiang-Fang; Meyer, Rachel A.; Swift, Robin Y.; Moore, H. Edgar; Kolkin, Melanie A.; Weisner, Carl C.; Rugani, Katherine M.; Hough, Holly J.; Toole, David C.] Duke Divin Sch, Durham, NC USA.
   [Williams, Redford B.] Duke Univ, Dept Psychiat & Behav Sci, Durham, NC USA.
   [Williams, Redford B.] Duke Univ, Behav Med Res Ctr, Durham, NC USA.
   [Williams, Redford B.; Williams, Virginia P.] Williams LifeSkills Inc, Durham, NC USA.
C3 Duke University; Duke University; Duke University; Duke University; Duke
   University; Duke University; Duke University
RP Proeschold-Bell, RJ (corresponding author), Duke Ctr Hlth Policy & Inequal Res, Duke Global Hlth Inst, Box 90392, Durham, NC 27708 USA.
EM rae.jean@duke.edu
RI Eagle, David/AAG-9344-2021
OI Turner, Elizabeth/0000-0002-7638-5942; Yao, Jia/0000-0001-8724-577X
FU Rural Church Area of The Duke Endowment
FX The United Methodist clergy of North Carolina, along with support from
   their bishops and leaders, made this trial possible. Data were collected
   and organized by Crystal MacAllum, Gail Thomas, Ed Mann, and their team
   at Westat, as well as Amanda Wallace and Alana Bennett. Thirteen
   Wellness Advocates implemented the intervention with great care. Amanda
   Wallace and Adeola Awodele helped prepare the manuscript. This trial was
   funded by the Rural Church Area of The Duke Endowment,
   http://dukeendowment.org/. The Duke University Arts and Sciences IRB
   protocol number is A0208.
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   ZEGER SL, 1988, BIOMETRICS, V44, P1049, DOI 10.2307/2531734
NR 45
TC 22
Z9 25
U1 0
U2 18
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0749-3797
EI 1873-2607
J9 AM J PREV MED
JI Am. J. Prev. Med.
PD SEP
PY 2017
VL 53
IS 3
BP 290
EP 299
DI 10.1016/j.amepre.2017.04.009
PG 10
WC Public, Environmental & Occupational Health; Medicine, General &
   Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; General & Internal Medicine
GA FE0QI
UT WOS:000407924400011
PM 28641912
DA 2025-06-11
ER

PT J
AU Agarwal, A
   Agarwal, M
   Garg, K
   Dalal, PK
   Trivedi, JK
   Srivastava, JS
AF Agarwal, Anju
   Agarwal, Manu
   Garg, Kabir
   Dalal, Pronob Kumar
   Trivedi, Jitendra Kumar
   Srivastava, J. S.
TI Metabolic syndrome and central obesity in depression: A cross-sectional
   study
SO INDIAN JOURNAL OF PSYCHIATRY
LA English
DT Article
DE Central obesity; depression; metabolic syndrome; obesity
ID 3RD NATIONAL-HEALTH; MAJOR DEPRESSION; GENERAL-POPULATION; ABDOMINAL
   OBESITY; BIPOLAR DISORDER; YOUNG-ADULTS; PREVALENCE; SCHIZOPHRENIA;
   SYMPTOMS; METAANALYSIS
AB Introduction: The current epidemiological data and meta-analyses indicate a bidirectional association between depression and metabolic syndrome (MetS).
   Aims: To assess the prevalence of metabolic syndrome and obesity in drug naive patients (in current episode) having Recurrent Major Depressive Disorder and Bipolar Depression.
   Method: This was a single point cross sectional observational study that involved administration of diagnostic and assessment tools and blood investigations. Recruitment for the study was done from a period of September 2008 to august 2009.
   Results: The prevalence of MetS was significantly more in the depression group when compared to healthy controls. The Bipolar depression group had 24% prevalence and recurrent depression group had 26% prevalence as opposed to none in the control group. The prevalence of MetS did not differ significantly amongst the both depression groups. Presence of central obesity was significantly more in the recurrent depression (30%) and Bipolar depression (24%) as compared to controls (8%). There was no statistically significant difference between the two depression subgroups.
   Discussion: Our study adds to the mounting evidence that links the presence of depression and metabolic syndrome. As we had ensured a drug free period of at least 3 months, the findings in our study indicate that the metabolic syndrome observed in our study is independent of drug exposure.
   Conclusions: This study demonstrated significantly more incidence of metabolic syndrome and central obesity in patients of depression than age and sex matched controls.
C1 [Agarwal, Anju] Eras Lucknow Med Coll, Dept Psychiat, Lucknow, Uttar Pradesh, India.
   [Agarwal, Manu; Garg, Kabir; Dalal, Pronob Kumar; Trivedi, Jitendra Kumar] King Georges Med Univ, Dept Psychiat, Lucknow 226003, Uttar Pradesh, India.
   [Srivastava, J. S.] Cent Drug Res Inst, Lucknow, Uttar Pradesh, India.
C3 King George's Medical University; Council of Scientific & Industrial
   Research (CSIR) - India; CSIR - Central Drug Research Institute (CDRI)
RP Garg, K (corresponding author), King Georges Med Univ, Dept Psychiat, Lucknow 226003, Uttar Pradesh, India.
EM kabirgarg@kgmcindia.edu
RI Dalal, Pronob/AAQ-2603-2020; Garg, Kabir/P-4228-2015
OI Garg, Kabir/0000-0003-1534-2129; DALAL, PRONOB KUMAR/0000-0001-7317-4480
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NR 63
TC 20
Z9 22
U1 1
U2 9
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, 400059, INDIA
SN 0019-5545
EI 1998-3794
J9 INDIAN J PSYCHIAT
JI Indian J. Psychiatry
PD JUL-SEP
PY 2016
VL 58
IS 3
BP 281
EP 286
DI 10.4103/0019-5545.192021
PG 6
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA EB8QK
UT WOS:000387655700008
PM 28066005
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Andersson, P
   von Schreeb, A
   Johansson, L
   Sturidsson, K
   Wetterborg, D
   Sorjonen, K
AF Andersson, Peter
   von Schreeb, Agnes
   Johansson, Linnea
   Sturidsson, Knut
   Wetterborg, Dan
   Sorjonen, Kimmo
TI Changes in Body Mass Index During Mandatory Forensic Psychiatric Care:
   Findings from a Long-Term (2009-2020) Cohort Study Based on Swedish
   Registry Data
SO INTERNATIONAL JOURNAL OF FORENSIC MENTAL HEALTH
LA English
DT Article
DE Metabolic syndrome (MetS); premature mortality; forensic mental health;
   somatic co-morbidity
ID WEIGHT-GAIN; MORTALITY GAP; SCHIZOPHRENIA; HEALTH; DISORDERS; RISK
AB Lifespan is reduced by approximately 15 years in individuals suffering from severe mental illnesses such as schizophrenia spectrum disorders. Contributing to this is an increased prevalence of metabolic syndrome, an assortment of factors that confer risk of diabetes type 2 and cardiovascular disease. Body Mass Index (BMI) is predictive of metabolic syndrome. Previous research indicates that the BMI of incarcerated individuals not suffering from a major mental disorder increase during incarceration, especially amongst females. However, information on the development of BMI during forensic psychiatric care is scarcer, and follow-up periods have been short. Thus, the authors extracted data from the Swedish National Forensic Psychiatric Register regarding the longitudinal development of BMI in 3389 individuals who received court mandated forensic psychiatric care in Sweden during 2009-2020. A significant increase in BMI by 1.1% per year was observed during the first four years of care. After this, changes were no longer significant. Factors associated with a larger increase in BMI were female gender, being prescribed antipsychotics, young age at admission, receiving outpatient care, and access to an external support person. There was an inverse association between BMI and symptom severity. Substantial heterogeneity was observed in longitudinal changes in individual BMI and in comparisons between individuals receiving care at different clinics.
C1 [Andersson, Peter; von Schreeb, Agnes; Johansson, Linnea; Sturidsson, Knut; Wetterborg, Dan; Sorjonen, Kimmo] Karolinska Inst, Dept Clin Neurosci, Div Psychol, S-17165 Stockholm, Sweden.
   [Andersson, Peter] Uppsala Univ, Ctr Clin Res Dalarna, Falun, Sweden.
C3 Karolinska Institutet; Uppsala University
RP Andersson, P (corresponding author), Karolinska Inst, Dept Clin Neurosci, Div Psychol, S-17165 Stockholm, Sweden.
EM peter.andersson@ki.se
OI Sturidsson, Knut/0000-0002-4130-2270; Andersson,
   Peter/0000-0002-1358-2463; Wetterborg, Dan/0000-0003-0833-0525
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NR 48
TC 1
Z9 1
U1 0
U2 4
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 1499-9013
EI 1932-9903
J9 INT J FORENSIC MENT
JI Int. J. Forensic Ment. Health
PD APR 2
PY 2024
VL 23
IS 2
BP 106
EP 116
DI 10.1080/14999013.2023.2214381
EA MAY 2023
PG 11
WC Criminology & Penology; Psychiatry
WE Social Science Citation Index (SSCI)
SC Criminology & Penology; Psychiatry
GA PO0V7
UT WOS:000993580400001
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Liu, Y
   Ettinger, AS
   Téllez-Rojo, M
   Sánchez, BN
   Zhang, ZZ
   Cantoral, A
   Hu, H
   Peterson, KE
AF Liu, Yun
   Ettinger, Adrienne S.
   Tellez-Rojo, Martha
   Sanchez, Brisa N.
   Zhang, Zhenzhen
   Cantoral, Alejandra
   Hu, Howard
   Peterson, Karen E.
TI Prenatal Lead Exposure, Type 2 Diabetes, and Cardiometabolic Risk
   Factors in Mexican Children at Age 10-18 Years
SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Article
DE blood lead; children; type 2 diabetes; cardiometabolic risk;
   cholesterols
ID METABOLIC SYNDROME; OXIDATIVE STRESS; INSULIN SENSITIVITY;
   CARDIOVASCULAR RISK; NATIONAL-HEALTH; ASSOCIATION; PREGNANCY; PLASMA;
   BLOOD; CHOLESTEROL
AB Context: Several cross-sectional studies have assessed the association of lead exposure with type 2 diabetes and cardiometabolic risk factors in adults; however, studies of such associations in childhood are rare.
   Objective: We assessed the prospective associations of prenatal exposure to lead with type 2 diabetes and cardiometabolic risk factors in children.
   Design: The Early Life Exposure in Mexico to Environmental Toxicants is a birth cohort study of pregnant women and their offspring.
   Setting: Public hospitals in Mexico City.
   Patients or Other Participants: Women were recruited during pregnancy; their offspring were recruited for a follow-up visit at age 10 to 18 years (n = 369).
   Main Outcome Measures: We measured fasting serum markers of type 2 diabetes and cardiometabolic risk factors in children, including fasting glucose, insulin, and lipids. The index of insulin resistance was calculated.
   Results: The geometric mean of maternal blood lead levels (BLLs) during pregnancy was 4.3 mu g/dL (95% confidence interval [CI]): 4.0-4.6 mu g/dL) in the entire sample. In boys, those with maternal BLLs = 5 mu g/dL (compared with those with BLLs < 5 mu g/dL) had significantly lower z scores for total cholesterol (beta = -0.41, 95% CI: -0.71, -0.12), high-density lipoprotein cholesterol (beta = -0.32, 95% CI: -0.59, -0.05), and low-density lipoprotein cholesterol (beta = -0.52, 95% CI: -0.81, -0.22), adjusting for covariates. No associations were detected in girls.
   Conclusions: In our study, we found that higher prenatal exposure to lead was associated with lower levels of cholesterol in children following a sex-specific pattern. Further studies with a larger sample size that examine whether sex is a potential modifier are needed to confirm our findings.
C1 [Liu, Yun; Ettinger, Adrienne S.; Peterson, Karen E.] Univ Michigan, Sch Publ Hlth, Dept Nutr Sci, 1867 SPH 1,1415 Washington Hts, Ann Arbor, MI 48109 USA.
   [Tellez-Rojo, Martha; Cantoral, Alejandra] Natl Inst Publ Hlth, Nutr & Hlth Res Ctr, Cuernavaca 62100, Morelos, Mexico.
   [Sanchez, Brisa N.; Zhang, Zhenzhen] Univ Michigan, Dept Biostat, Sch Publ Hlth, Ann Arbor, MI 48109 USA.
   [Hu, Howard] Univ Washington, Dept Environm & Occupat Hlth Sci, Sch Publ Hlth, Seattle, WA 98195 USA.
   [Hu, Howard; Peterson, Karen E.] Univ Michigan, Dept Environm Hlth Sci, Sch Publ Hlth, Ann Arbor, MI 48109 USA.
C3 University of Michigan System; University of Michigan; Instituto
   Nacional de Salud Publica; University of Michigan System; University of
   Michigan; University of Washington; University of Washington Seattle;
   University of Michigan System; University of Michigan
RP Peterson, KE (corresponding author), Univ Michigan, Sch Publ Hlth, Dept Nutr Sci, 1867 SPH 1,1415 Washington Hts, Ann Arbor, MI 48109 USA.
EM karenep@umich.edu
RI Hu, Howard/AAV-5360-2021; Cantoral, Alejandra/AAA-3615-2021; Ettinger,
   Adrienne/ABF-6655-2020
OI Sanchez, Brisa/0000-0002-4824-7200; Tellez Rojo,
   Martha/0000-0003-3322-3334; Hu, Howard/0000-0002-3676-2707; Ettinger,
   Adrienne S./0000-0002-0200-8677
FU U.S. National Institutes of Health [R01ES021446, R01ES007821]; National
   Institute of Environmental Health Sciences/the U.S. Environmental
   Protection Agency [P01ES022844]; National Institute of Environmental
   Health Sciences [P20ES018171]; National Institute of Public
   Health/Ministry of Health of Mexico; National Institute of Diabetes and
   Digestive and Kidney Diseases [P30DK020572]; National Institute of
   Diabetes and Digestive and Kidney Diseases [P30DK020572] Funding Source:
   NIH RePORTER
FX The study was supported by grants R01ES021446 and R01ES007821 from the
   U.S. National Institutes of Health, grant P01ES022844 from the National
   Institute of Environmental Health Sciences/the U.S. Environmental
   Protection Agency, and grant P20ES018171 from the National Institute of
   Environmental Health Sciences. This study was also supported and
   partially funded by the National Institute of Public Health/Ministry of
   Health of Mexico and by grant P30DK020572 (Michigan Diabetes Research
   Center) from the National Institute of Diabetes and Digestive and Kidney
   Diseases.
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NR 52
TC 14
Z9 15
U1 0
U2 6
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0021-972X
EI 1945-7197
J9 J CLIN ENDOCR METAB
JI J. Clin. Endocrinol. Metab.
PD JAN
PY 2020
VL 105
IS 1
BP 210
EP 218
DI 10.1210/clinem/dgz038
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA KS2XC
UT WOS:000518172400020
PM 31608940
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Schmitt, A
   Maurus, I
   Rossner, MJ
   Roh, A
   Lembeck, M
   von Wilmsdorff, M
   Takahashi, S
   Rauchmann, B
   Keeser, D
   Hasan, A
   Malchow, B
   Falkai, P
AF Schmitt, Andrea
   Maurus, Isabel
   Rossner, Moritz J.
   Roh, Astrid
   Lembeck, Moritz
   von Wilmsdorff, Martina
   Takahashi, Shun
   Rauchmann, Boris
   Keeser, Daniel
   Hasan, Alkomiet
   Malchow, Berend
   Falkai, Peter
TI Effects of Aerobic Exercise on Metabolic Syndrome, Cardiorespiratory
   Fitness, and Symptoms in Schizophrenia Include Decreased Mortality
SO FRONTIERS IN PSYCHIATRY
LA English
DT Review
DE aerobic exercise; endurance training; high-intensity interval training;
   metabolic syndrome; mortality; schizophrenia; cognition; positive and
   negative symptoms
ID CORONARY-HEART-DISEASE; ALL-CAUSE MORTALITY; PHYSICAL-ACTIVITY; 1ST
   EPISODE; COMPARATIVE METAANALYSIS; CARDIOMETABOLIC DISEASE;
   CARDIOVASCULAR EVENTS; ANTIPSYCHOTIC-DRUGS; PSYCHOTIC DISORDERS;
   INSULIN-RESISTANCE
AB Schizophrenia is a severe psychiatric disorder with a lifetime prevalence of about 1%. People with schizophrenia have a 4-fold higher prevalence of metabolic syndrome than the general population, mainly because of antipsychotic treatment but perhaps also because of decreased physical activity. Metabolic syndrome is a risk factor for cardiovascular diseases, and the risk of these diseases is 2- to 3-fold higher in schizophrenia patients than in the general population. The suicide risk is also higher in schizophrenia, partly as a result of depression, positive, and cognitive symptoms of the disease. The higher suicide rate and higher rate of cardiac mortality, a consequence of the increased prevalance of cardiovascular diseases, contribute to the reduced life expectancy, which is up to 20 years lower than in the general population. Regular physical activity, especially in combination with psychosocial and dietary interventions, can improve parameters of the metabolic syndrome and cardiorespiratory fitness. Furthermore, aerobic exercise has been shown to improve cognitive deficits; total symptom severity, including positive and negative symptoms; depression; quality of life; and global functioning. High-intensity interval endurance training is a feasible and effective way to improve cardiorespiratory fitness and metabolic parameters and has been established as such in somatic disorders. It may have more beneficial effects on the metabolic state than more moderate and continuous endurance training methods, but to date it has not been investigated in schizophrenia patients in controlled, randomized trials. This review discusses physical training methods to improve cardiorespiratory fitness and reduce metabolic syndrome risk factors and symptoms in schizophrenia patients. The results of studies and future high-quality clinical trials are expected to lead to the development of an evidence-based physical training program for patients that includes practical recommendations, such as the optimal length and type of aerobic exercise programs and the ideal combination of exercise, psychoeducation, and individual weight management sessions.
C1 [Schmitt, Andrea; Maurus, Isabel; Rossner, Moritz J.; Roh, Astrid; Lembeck, Moritz; Takahashi, Shun; Hasan, Alkomiet; Falkai, Peter] Ludwig Maximilians Univ Munchen, Univ Hosp, Dept Psychiat & Psychotherapy, Munich, Germany.
   [Schmitt, Andrea] Univ Sao Paulo, Inst Psychiat, Lab Neurosci LIM27, Sao Paulo, Brazil.
   [von Wilmsdorff, Martina] Heinrich Heine Univ, Med Fac, Dept Psychiat & Psychotherapy, Dusseldorf, Germany.
   [Takahashi, Shun] Wakayama Med Univ, Dept Neuropsychiat, Wakayama, Japan.
   [Rauchmann, Boris; Keeser, Daniel] Ludwig Maximilians Univ Munchen, Univ Hosp, Dept Radiol, Munich, Germany.
   [Malchow, Berend] Univ Hosp Jena, Dept Psychiat & Psychotherapy, Jena, Germany.
C3 University of Munich; Universidade de Sao Paulo; Heinrich Heine
   University Dusseldorf; Wakayama Medical University; University of
   Munich; Friedrich Schiller University of Jena
RP Schmitt, A (corresponding author), Ludwig Maximilians Univ Munchen, Univ Hosp, Dept Psychiat & Psychotherapy, Munich, Germany.; Schmitt, A (corresponding author), Univ Sao Paulo, Inst Psychiat, Lab Neurosci LIM27, Sao Paulo, Brazil.
EM andrea.schmitt@med.uni-muenchen.de
RI Rauchmann, Boris-Stephan/GLQ-9798-2022; Malchow, Berend/AAM-9172-2020;
   Maurus, Isabel/HMO-5534-2023; Takahashi, Shun/AIF-1768-2022; Falkai,
   Peter/E-3273-2017; Keeser, Daniel/C-8888-2016
OI Falkai, Peter/0000-0003-2873-8667; Keeser, Daniel/0000-0002-0244-1024
FU Deutsche Forschungsgemeinschaft (DFG): Klinische Forschergruppe (KFO)
   241 and PsyCourse [FA241/16-1]; German Federal Ministry of Education and
   Research (BMBF) through the research network on psychiatric diseases
   ESPRIT [01EE1407E]
FX This research was funded by the following grants from the Deutsche
   Forschungsgemeinschaft (DFG): Klinische Forschergruppe (KFO) 241 and
   PsyCourse to PF (FA241/16-1). Further funding was received from the
   German Federal Ministry of Education and Research (BMBF) through the
   research network on psychiatric diseases ESPRIT (grant number 01EE1407E)
   to PF, AH, and AS.
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NR 125
TC 56
Z9 59
U1 2
U2 40
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-0640
J9 FRONT PSYCHIATRY
JI Front. Psychiatry
PD DEC 21
PY 2018
VL 9
AR 690
DI 10.3389/fpsyt.2018.00690
PG 12
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA HF2QE
UT WOS:000454080700001
PM 30622486
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Matic, TB
   Toncev, G
   Gavrilovic, A
   Aleksic, D
AF Matic, Tatjana Boskovic
   Toncev, Gordana
   Gavrilovic, Aleksandar
   Aleksic, Dejan
TI Suffering from cerebral small vessel disease with and without metabolic
   syndrome
SO OPEN MEDICINE
LA English
DT Article
DE cerebral small vessel disease; cognitive impairment; depression;
   metabolic syndrome
ID QUALITY-OF-LIFE; COGNITIVE IMPAIRMENT; RISK-FACTORS; DEPRESSION;
   DEMENTIA; ASSOCIATIONS; STROKE
AB Background: Cerebral small vessel disease (CSVD) and metabolic syndrome were separately associated with cognitive impairment and depression. However, whether metabolic syndrome adds to cognitive impairment and depression in patients who already have CSVD remained unanswered.
   Objective: The aim of our study was to investigate the association of metabolic syndrome with cognitive impairment and depression in patients with CSVD who have lacunar lesions or white matter hyperintensities.
   Methods: This prospective cohort study was conducted at Neurology Clinic, Clinical Center, Kragujevac, Serbia. Main outcomes of the study were cognitive assessment, and assessment of depression among hospitalized patients with or without CSVD.
   Results: The study included 74 inpatients, 25 of them having lacunary infarctions, 24 with the white matter hyperintensities, and 25 control patients without CSVD. The CSVD was accompanied by impairment of cognition and depression, the patients with lacunary lesions being more cognitively impaired and more depressive than the patients with the white matter hyperintensities. The patients with CSVD who also had metabolic syndrome were more cognitively impaired and depressed than the patients with CSVD alone.
   Conclusions: In conclusion, our study showed that metabolic syndrome is associated with further worsening of already impaired cognition and existing depression in patients with CSVD.
C1 [Matic, Tatjana Boskovic] Clin Ctr Kragujevac, Clin Neurol, Zmaj Jovina 30, Kragujevac 34000, Serbia.
   [Toncev, Gordana; Gavrilovic, Aleksandar; Aleksic, Dejan] Univ Kragujevac, Fac Med Sci, Kragujevac, Serbia.
   [Toncev, Gordana; Gavrilovic, Aleksandar; Aleksic, Dejan] Univ Kragujevac, Clin Ctr, Kragujevac, Serbia.
C3 University of Kragujevac; University of Kragujevac
RP Matic, TB (corresponding author), Clin Ctr Kragujevac, Clin Neurol, Zmaj Jovina 30, Kragujevac 34000, Serbia.
EM stmatic@ptt.rs
RI Aleksić, Dejan/JGD-1786-2023
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NR 23
TC 5
Z9 5
U1 0
U2 3
PU DE GRUYTER POLAND SP Z O O
PI WARSAW
PA BOGUMILA ZUGA 32A STR, 01-811 WARSAW, MAZOVIA, POLAND
SN 2391-5463
J9 OPEN MED-WARSAW
JI Open Med.
PY 2019
VL 14
IS 1
BP 479
EP 484
DI 10.1515/med-2019-0051
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA IJ1NY
UT WOS:000475666500001
PM 31231684
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Sung, JD
   Choi, YH
   Park, JB
AF Sung, Jidong
   Choi, Yoon-Ho
   Park, Jeong Bae
TI Metabolic syndrome is associated with delayed heart rate recovery after
   exercise
SO JOURNAL OF KOREAN MEDICAL SCIENCE
LA English
DT Article
DE heart rate; heart rate recovery; metabolic syndrome X; vagal
   reactivation
ID TYPE-2 DIABETIC-PATIENTS; RATE-VARIABILITY; CARDIOVASCULAR-DISEASE;
   INSULIN-RESISTANCE; BLOOD-PRESSURE; ALL-CAUSE; PREDICTOR; MORTALITY;
   HYPERINSULINEMIA; DYSFUNCTION
AB Heart rate (HR) recovery after exercise is a function of vagal reactivation, and its impairment is a predictor of overall mortality and adverse cardiovascular events. While metabolic syndrome is associated with sympathetic overactivity, little is known about the relationship between metabolic syndrome and HR recovery. A symptom-limited exercise stress test in healthy subjects (n=1,434) was used to evaluate HR recovery. Metabolic syndrome was defined according to the National Cholesterol Education Program's Adult Treatment Panel III (NCEP ATP-III) criteria. Seventeen percent of subjects had !: 3 criteria for metabolic syndrome. HR recovery was lower in men than women and in smokers than nonsmokers. The subject with metabolic syndrome (vs. without) showed lower HR recovery (10.3 +/- 11.6 vs. 13.6 +/- 9.7 per minute) and higher resting HR (64.3 +/- 10.3 vs. 61.6 +/- 9.1 per minute). HR recovery correlated inversely to age (r=-0.25, p < 0.0001), but not to resting HR or maximal oxygen uptake. Delayed HR recovery was associated with metabolic syndrome after an adjustment for age, sex, resting HR and smoking (p < 0.01). Metabolic syndrome is associated with impaired vagal reactivation. Adverse cardiovascular outcomes associated with metabolic syndrome may be mediated by the failure of vagal reactivation in addition to sympathetic overactivity.
C1 Sungkyunkwan Univ, Sch Med, Dept Med Cardiol, Cheil Gen Hosp, Seoul 100380, South Korea.
   Sungkyunkwan Univ, Sch Med, Ctr Hlth Promot,Samsung Med Ctr, Cheil Gen Hosp, Seoul 100380, South Korea.
C3 Sungkyunkwan University (SKKU); Sungkyunkwan University (SKKU); Samsung
   Medical Center
RP Park, JB (corresponding author), Sungkyunkwan Univ, Sch Med, Dept Med Cardiol, Cheil Gen Hosp, 1-19 Mookjung Dong, Seoul 100380, South Korea.
EM parkjb@skku.edu
RI Choi, Yoon Ho/JXM-6303-2024; sung, jd/O-5936-2014
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NR 35
TC 25
Z9 33
U1 0
U2 6
PU KOREAN ACAD MEDICAL SCIENCES
PI SEOUL
PA 302 75 DONG DU ICHON, DONG YONGSAN KU, SEOUL 140 031, SOUTH KOREA
SN 1011-8934
EI 1598-6357
J9 J KOREAN MED SCI
JI J. Korean Med. Sci.
PD AUG
PY 2006
VL 21
IS 4
BP 621
EP 626
DI 10.3346/jkms.2006.21.4.621
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 077OF
UT WOS:000240038500006
PM 16891803
OA Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Chan, AML
   Ng, AMH
   Yunus, MHM
   Idrus, RBH
   Law, JX
   Yazid, MD
   Chin, KY
   Shamsuddin, SA
   Lokanathan, Y
AF Chan, Alvin Man Lung
   Ng, Angela Min Hwei
   Mohd Yunus, Mohd Heikal
   Idrus, Ruszymah Bt Hj
   Law, Jia Xian
   Yazid, Muhammad Dain
   Chin, Kok-Yong
   Shamsuddin, Sharen Aini
   Lokanathan, Yogeswaran
TI Recent Developments in Rodent Models of High-Fructose Diet-Induced
   Metabolic Syndrome: A Systematic Review
SO NUTRIENTS
LA English
DT Review
DE high fructose; metabolic syndrome; syndrome X; metabolic syndrome X;
   rodent; rat; mice; mouse
ID OXIDATIVE STRESS; RAT; ASSOCIATION; DYSFUNCTION; DISEASE; CONSUMPTION;
   ACTIVATION; GLUCOSE; WISTAR; TISSUE
AB Metabolic syndrome (MetS) is the physiological clustering of hypertension, hyperglycemia, hyperinsulinemia, dyslipidemia, and insulin resistance. The MetS-related chronic illnesses encompass obesity, the cardiovascular system, renal operation, hepatic function, oncology, and mortality. To perform pre-clinical research, it is imperative that these symptoms be successfully induced and optimized in lower taxonomy. Therefore, novel and future applications for a disease model, if proven valid, can be extrapolated to humans. MetS model establishment is evaluated based on the significance of selected test parameters, paradigm shifts from new discoveries, and the accessibility of the latest technology or advanced methodologies. Ultimately, the outcome of animal studies should be advantageous for human clinical trials and solidify their position in advanced medicine for clinicians to treat and adapt to serious or specific medical situations. Rodents (Rattus norvegicus and Mus musculus) have been ideal models for mammalian studies since the 18th century and have been mapped extensively. This review compiles and compares studies published in the past five years between the multitude of rodent comparative models. The response factors, niche parameters, and replicability of diet protocols are also compiled and analyzed to offer insight into MetS-related disease-specific modelling.
C1 [Chan, Alvin Man Lung; Ng, Angela Min Hwei; Idrus, Ruszymah Bt Hj; Law, Jia Xian; Yazid, Muhammad Dain; Shamsuddin, Sharen Aini; Lokanathan, Yogeswaran] Univ Kebangsaan Malaysia, Med Ctr, Fac Med, Ctr Tissue Engn & Regenerat Med, Jalan Yaacob Latif, Kuala Lumpur 56000, Malaysia.
   [Chan, Alvin Man Lung] Ming Med Sdn Bhd, D3-3 2nd Floor,Block D3 Dana 1 Commercial Ctr, Petaling Jaya 47101, Malaysia.
   [Mohd Yunus, Mohd Heikal] Univ Kebangsaan Malaysia, Med Ctr, Fac Med, Dept Physiol, Jalan Yaacob Latif, Kuala Lumpur 56000, Malaysia.
   [Chin, Kok-Yong] Univ Kebangsaan Malaysia, Med Ctr, Fac Med, Dept Pharmacol, Jalan Yaacob Latif, Kuala Lumpur 56000, Malaysia.
C3 Universiti Kebangsaan Malaysia; Universiti Kebangsaan Malaysia;
   Universiti Kebangsaan Malaysia
RP Lokanathan, Y (corresponding author), Univ Kebangsaan Malaysia, Med Ctr, Fac Med, Ctr Tissue Engn & Regenerat Med, Jalan Yaacob Latif, Kuala Lumpur 56000, Malaysia.
EM alvinchanmanlung@outlook.com; angela@ppukm.ukm.edu.my;
   mohdheikalyunus@yahoo.com; ruszymah@ppukm.ukm.edu.my;
   lawjx@ppukm.ukm.edu.my; dain@ukm.edu.my; chinkokyong@ppukm.ukm.edu.my;
   s.sharenaini@ppukm.ukm.edu.my; lyoges@ppukm.ukm.edu.my
RI Lokanathan, Yogeswaran/Q-5117-2019; Yazid, Muhammad/AAU-6355-2021; Chin,
   Kok-Yong/B-6309-2015; Law, Jia Xian/M-9728-2017; Mohd Yunus, Mohd
   Heikal/AAV-7037-2020
OI Chan, Alvin/0000-0001-9400-558X; Chin, Kok-Yong/0000-0001-6628-1552;
   Law, Jia Xian/0000-0001-9045-5145; Lokanathan,
   Yogeswaran/0000-0002-9548-6490; Yazid, Muhammad
   Dain/0000-0001-6162-4405; Mohd Yunus, Mohd Heikal/0000-0002-6793-2043
FU Ming Medical Sdn. Bhd. [FF-2020-469]; Universiti Kebangsaan Malaysia
   [FF-2020-469/1, DPK-2021-006]
FX This work was supported by grants by Ming Medical Sdn. Bhd.
   (FF-2020-469) and Universiti Kebangsaan Malaysia (FF-2020-469/1 and
   DPK-2021-006).
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NR 54
TC 44
Z9 45
U1 1
U2 15
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD AUG
PY 2021
VL 13
IS 8
AR 2497
DI 10.3390/nu13082497
PG 21
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA UH4FF
UT WOS:000689888300001
PM 34444658
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Vuksan-Cusa, B
   Jakovljevic, M
   Sagud, M
   Peles, AM
   Marcinko, D
   Topic, R
   Mihaljevic, S
   Sertic, J
AF Vuksan-Cusa, Bjanka
   Jakovljevic, Miro
   Sagud, Marina
   Peles, Alma Mihaljevic
   Marcinko, Darko
   Topic, Radmila
   Mihaljevic, Sanea
   Sertic, Jadranka
TI Metabolic syndrome and serum homocysteine in patients with bipolar
   disorder and schizophrenia treated with second generation antipsychotics
SO PSYCHIATRY RESEARCH
LA English
DT Article
DE Bipolar disorder; Schizophrenia; Homocysteine; Metabolic syndrome;
   Cardiovascular diseases
ID RISK-FACTORS; CARDIOVASCULAR-DISEASE; FOLATE; ASSOCIATION;
   HYPERHOMOCYSTEINEMIA; DEPRESSION; IMPACT
AB There is accumulating evidence for an increased prevalence of metabolic syndrome (MetS) in bipolar patients, which is comparable to the prevalence of MetS in patients with schizophrenia. Hyperhomocysteinaemia has emerged as an independent and graded risk factor for the development of cardiovascular disease (CVD), which is, at the same time, the primary clinical outcome of MetS. The aim of this study was to ascertain if the presence of MetS was associated with hyperhomocysteinaemia in patients with bipolar disorder (N = 36) and schizophrenia (N = 46) treated with second-generation antipsychotics (SGA). MetS was defined according to the National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP-III) criteria and the cut-off point for hyperhomocysteinaemia was set up at 15 mu mol l(-1). Results of the study indicated that the presence of the MetS is statistically significantly associated with the elevated serum homocysteine in all participants. As hyperhomocysteinaemia has emerged as an independent risk factor for psychiatric disorder and CVD, it could be useful to include fasting homocysteine serum determination in the diagnostic panels of psychiatric patients to obtain a better assessment of their metabolic risk profile. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
C1 [Vuksan-Cusa, Bjanka; Jakovljevic, Miro; Sagud, Marina; Peles, Alma Mihaljevic; Marcinko, Darko; Topic, Radmila] Univ Hosp, Psychiat Clin, Zagreb, Croatia.
   [Mihaljevic, Sanea] Gen Hosp Tomislav Bardek, Virovitica, Croatia.
   [Sertic, Jadranka] Univ Hosp, Dept Lab Diagnost, Zagreb, Croatia.
RP Vuksan-Cusa, B (corresponding author), Univ Hosp, Psychiat Clin, Kispaticeva St, Zagreb, Croatia.
EM bjanka.vuksan@inet.hr
RI Sagud, Marina/G-1265-2015
OI Sagud, Marina/0000-0001-9620-2181
FU Ministry of Science, Education and Sport of the Republic of Croatia
   [01081]
FX This work was supported by the Ministry of Science, Education and Sport
   of the Republic of Croatia. Grant No.01081.
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NR 43
TC 30
Z9 33
U1 0
U2 10
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0165-1781
J9 PSYCHIAT RES
JI Psychiatry Res.
PD AUG 30
PY 2011
VL 189
IS 1
BP 21
EP 25
DI 10.1016/j.psychres.2010.11.021
PG 5
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 822TW
UT WOS:000295073500003
PM 21216014
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Vepa, A
   Joseph, PB
   Ahmed, F
   Pareek, M
   Khunti, K
AF Vepa, Abhinav
   Joseph, P. Bae
   Ahmed, Faheem
   Pareek, Manish
   Khunti, Kamlesh
TI COVID-19 and ethnicity: A novel pathophysiological role for inflammation
SO DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS
LA English
DT Article
DE COVID-19; SARS CoV-2; BAME; Ethnicity; Metabolic syndrome; Type 2
   diabetes mellitus; Obesity; Inflammation; Insulin resistance;
   Cardiovascular risk; Cytokine storm; Visceral fat; Psychological stress
ID METABOLIC SYNDROME; PSYCHOLOGICAL STRESS; OXIDATIVE STRESS;
   MENTAL-ILLNESS; SLEEP-APNEA; HEALTH; RISK; PREVALENCE; DISEASE; OBESITY
AB Introduction: There have been recent mounting concerns regarding multiple reports stating a significantly elevated relative-risk of COVID-19 mortality amongst the Black and Minority Ethnic (BAME) population. An urgent national enquiry investigating the possible reasons for this phenomenon has been issued in the UK. Inflammation is at the forefront of COVID-19 research as disease severity appears to correlate with pro-inflammatory cytokine dysregulation. This narrative review aims to shed light on the novel, pathophysiological role of inflammation in contributing towards the increased COVID-19 mortality risk amongst the BAME population.
   Methods: Searches in PubMed, Medline, Scopus, medRxiv and Google Scholar were performed to identify articles published in English from inception to 18th June 2020. These databases were searched using keywords including: 'COVID-19' or 'Black and Minority Ethnic' or 'Inflammation'. A narrative review was synthesized using these included articles.
   Results: We suggest a novel pathophysiological mechanism by which acute inflammation from COVID-19 may augment existing chronic inflammation, in order to potentiate a 'cytokine storm' and thus the more severe disease phenotype observed in the BAME population. Obesity, insulin resistance, cardiovascular disease, psychological stress, chronic infections and genetic predispositions are all relevant factors which may be contributing to elevated chronic systemic inflammation amongst the BAME population.
   Conclusion: Overall, this review provides early insights and directions for ongoing research regarding the pathophysiological mechanisms that may explain the severe COVID-19 disease phenotype observed amongst the BAME population. We suggest 'personalization' of chronic disease management, which can be used with other interventions, in order to tackle this. (c) 2020 Diabetes India. Published by Elsevier Ltd. All rights reserved.
C1 [Vepa, Abhinav; Joseph, P. Bae] Milton Keynes Univ Hosp NHS Fdn Trust, Dept Med, Milton Keynes, Bucks, England.
   [Ahmed, Faheem] NHS England, Skipton House, London, England.
   [Pareek, Manish] Univ Leicester, Dept Resp Sci, Leicester, Leics, England.
   [Khunti, Kamlesh] Univ Leicester, Diabet Res Ctr, Leicester, Leics, England.
C3 University of Leicester; University of Leicester
RP Vepa, A (corresponding author), Milton Keynes Univ Hosp NHS Fdn Trust, Dept Med, Milton Keynes, Bucks, England.
EM Vepa.Abhinav@nhs.net
RI /GQB-2573-2022; Ahmed, Faheem/KDN-1745-2024
OI Pareek, Manish/0000-0003-1521-9964; Khunti, Kamlesh/0000-0003-2343-7099;
   Vepa, Abhinav/0000-0001-5858-1109
FU National Institute for Health Research (NIHR) Applied Research
   Collaboration East Midlands (ARC EM); NIHR Leicester Biomedical Research
   Centre (BRC); COVID [MR/V027549/1] Funding Source: UKRI
FX KK is supported by the National Institute for Health Research (NIHR)
   Applied Research Collaboration East Midlands (ARC EM) and the NIHR
   Leicester Biomedical Research Centre (BRC). The views expressed are
   those of the author(s) and not necessarily those of the NIHR, NHS or the
   Department of Health and Social Care.
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NR 143
TC 41
Z9 42
U1 0
U2 15
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1871-4021
EI 1878-0334
J9 DIABETES METAB SYND
JI Diabetes Metab. Syndr.-Clin. Res. Rev.
PD SEP-OCT
PY 2020
VL 14
IS 5
BP 1043
EP 1051
DI 10.1016/j.dsx.2020.06.056
PG 9
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA OG9KS
UT WOS:000582194300069
PM 32640416
OA Green Published
DA 2025-06-11
ER

PT J
AU Wang, Q
   Chair, SY
   Wong, EML
AF Wang, Qun
   Chair, Sek Ying
   Wong, Eliza Mi-Ling
TI The effects of a lifestyle intervention program on physical outcomes,
   depression, and quality of life in adults with metabolic syndrome: A
   randomized clinical trial
SO INTERNATIONAL JOURNAL OF CARDIOLOGY
LA English
DT Article
DE Metabolic syndrome; Lifestyle intervention; Body weight; Depression
   Quality of life
ID ACUTE CORONARY SYNDROME; CARDIOVASCULAR RISK; WEIGHT-LOSS; HOSPITAL
   ANXIETY; KOREAN ADULTS; HEALTH; EXERCISE; METAANALYSIS; EDUCATION;
   FITNESS
AB Background/objectives: Lifestyle modification is recommended as the primary intervention for metabolic syndrome (MetS). The study was to examine the effects of a lifestyle intervention program (LIP) on physical outcomes, depression, and quality of life (QoL) in Chinese adults with MetS.
   Methods: A randomized control trial design was used. A three-month LIP guided by the Health Promotion Model was developed, including a lifestyle modification booklet, one session of discharge education, and six telephone follow-ups. Patients with MetS were recruited from the inpatient departments of a hospital and were randomized to receive either the LIP or usual care. The physical outcomes, depression (Depression subscale of Hospital Anxiety and Depression Scale), and QoL (Medical Outcome Study Short Form-12, SF-12) were measured at baseline, one-month (T1) and three-month (T2). The effects of the LIP were examined by the generalized estimating equation (GEE) model.
   Results: The study recruited 173 participants, with 86 in the intervention group and 87 in the control. Continuous improvements were observed in all the study outcomes in the intervention group. The GEE model revealed significant improvements in body weight (T1: p - 0.017, T2: p - 0.007), body mass index (T1: p - 0.015, T2: p = 0.009), depression (T1: p = 0.027, T2: p < 0.001), and physical aspects of QoL at T2 (p= 0.02).
   Conclusions: The current LIP was effective in losing body weight, improving depression and QoL ofMetS populations in three-month observation. Considering its low-cost and convenience, the LIP could be applied in clinical practice to improve patient outcomes. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
C1 [Wang, Qun; Chair, Sek Ying; Wong, Eliza Mi-Ling] Chinese Univ Hong Kong, Nethersole Sch Nursing, Shatin, Hong Kong, Peoples R China.
C3 Chinese University of Hong Kong
RP Wang, Q (corresponding author), Chinese Univ Hong Kong, Room 821,Esther Lee Bldg, Shatin, Hong Kong, Peoples R China.
EM qunwang@cuhk.edu.hk
RI Chair, Sek/IVV-5916-2023; Wong, Eliza/AAH-6193-2020; WANG,
   Qun/AAP-9908-2021; Chair, Sek Ying/G-9965-2016
OI Chair, Sek Ying/0000-0003-2387-7035; Wong, Eliza ML/0000-0003-0698-9000;
   Wang, Qun/0000-0001-7594-8312
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NR 59
TC 43
Z9 45
U1 2
U2 27
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0167-5273
EI 1874-1754
J9 INT J CARDIOL
JI Int. J. Cardiol.
PD MAR 1
PY 2017
VL 230
BP 461
EP 467
DI 10.1016/j.ijcard.2016.12.084
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Cardiovascular System & Cardiology
GA EQ2MQ
UT WOS:000397904000073
PM 28040281
DA 2025-06-11
ER

PT J
AU Tanaka, G
   Kato, Y
   Matsumura, K
   Horiguchi, M
   Ogasawara, H
   Sawada, Y
AF Tanaka, Gohichi
   Kato, Yuichi
   Matsumura, Kenta
   Horiguchi, Masami
   Ogasawara, Haruko
   Sawada, Yukihiro
TI The association between chronic psychosocial stress, allostatic load,
   and vascular health in asymptomatic young men: A pilot study using a
   novel finger arterial stiffness index
SO JAPANESE PSYCHOLOGICAL RESEARCH
LA English
DT Article
DE arterial stiffness; small artery and arteriole; allostatic load;
   psychosocial stress; cardiovascular health
ID C-REACTIVE PROTEIN; INSULIN-RESISTANCE SYNDROME; CARDIOVASCULAR RISK;
   METABOLIC SYNDROME; BLOOD-PRESSURE; CLINICAL-APPLICATIONS; DISEASE;
   ELASTICITY; HYPERTENSION; DEPRESSION
AB A novel index of finger arterial stiffness (FSI) was tested in terms of the relationship with risk markers for preclinical cardiovascular disease. In addition, we examined if the association between psychosocial factors and FSI was explained by allostatic load markers in 37 healthy young men aged 24.8 +/- 4.0 years. The FSI was devised based on an exponential model of the finger arterial pressure-volume relationship. The allostatic load index (ALI) as a cumulative risk marker was defined by the mean of standard scores for nine variables: resting systolic and diastolic blood pressure, waist/hip ratio, high-density lipoprotein cholesterol (HDL-C), total cholesterol/HDL-C ratio, triglycerides, hemoglobin A1c, insulin resistance, and high sensitivity C-reactive protein (CRP). Partial correlations controlling for age were significant for FSI with HDL-C (r = -.36), CRP (r = .39), ALI (r = .40), unhealthy overall eating habits (r = .34), hostility using the Buss-Perry Aggression Questionnaire (r = .38), and manageability in Sense of Coherence (r = -.38). In conclusion, FSI seems to be associated with vascular proinflammation as well as with overall physiological dysregulation and allostatic load. These associations were moderated by eating lifestyle and psychosocial stress.
C1 [Tanaka, Gohichi] Sapporo Med Univ, Dept Psychol, Ctr Med Educ, Chuo Ku, Sapporo, Hokkaido 0608556, Japan.
   [Matsumura, Kenta] Natl Ctr Neurol & Psychiat, Tokyo, Japan.
   [Ogasawara, Haruko] Hokkaido Univ, Sapporo, Hokkaido 060, Japan.
C3 Sapporo Medical University; National Center for Neurology & Psychiatry -
   Japan; Hokkaido University
RP Tanaka, G (corresponding author), Sapporo Med Univ, Dept Psychol, Ctr Med Educ, Chuo Ku, South 1,West 17, Sapporo, Hokkaido 0608556, Japan.
EM gtanaka@sapmed.ac.jp
RI Tanaka, Gohichi/N-3016-2019; Matsumura, Kenta/ABH-9288-2020
OI Matsumura, Kenta/0000-0002-4271-1543
FU Grants-in-Aid for Scientific Research [22570225, 21300252] Funding
   Source: KAKEN
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NR 63
TC 3
Z9 7
U1 0
U2 14
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0021-5368
EI 1468-5884
J9 JPN PSYCHOL RES
JI Jpn. Psychol. Res.
PD MAY
PY 2011
VL 53
IS 2
BP 140
EP 154
DI 10.1111/j.1468-5884.2011.00461.x
PG 15
WC Psychology, Multidisciplinary
WE Social Science Citation Index (SSCI)
SC Psychology
GA 762CE
UT WOS:000290449100005
OA Bronze
DA 2025-06-11
ER

PT J
AU Skroza, N
   Proietti, I
   Bernardini, N
   La Viola, G
   Nicolucci, F
   Pampena, R
   Tolino, E
   Zuber, S
   Mancini, MT
   Soccodato, V
   Balduzzi, V
   Potenza, C
AF Skroza, N.
   Proietti, I.
   Bernardini, N.
   La Viola, G.
   Nicolucci, F.
   Pampena, R.
   Tolino, E.
   Zuber, S.
   Mancini, M. T.
   Soccodato, V.
   Balduzzi, V.
   Potenza, C.
TI Efficacy of food supplement to improve metabolic syndrome parameters in
   patients affected by moderate to severe psoriasis during anti-TNFα
   treatment
SO GIORNALE ITALIANO DI DERMATOLOGIA E VENEREOLOGIA
LA English
DT Article
DE Psoriasis; Metabolic syndrome X; Oxidative stress
AB Aim. Psoriasis is a systemic inflammatory immune-mediated skin disease. Recently a relationship with metabolic syndrome in terms of psoriasis severity and response to therapy was observed.
   Methods. We performed an open-label randomized controlled study to evaluate the role of a nutraceutical containing Q10 coenzyme, Krill-oil, lipoic acid, resveratrol, Vitis vinifera seed oil, vitamin E and selenium in addition to etanercept therapy for patients affected by psoriasis and metabolic syndrome. Forty patients were enrolled and divided into two arms, one receiving only etanercept, one other receiving also the neutraceutical. After a period of 3 months (T1) a second evaluation of the considered parameters was performed.
   Results. At T1 statistically significant differences were detected in HDL cholesterol and triglycerides values both comparing the two arms and in the nutraceutical arm.
   Conclusion. Our results show that the dietary addiction of the nutraceutical to the etanercept therapy in patients affected by both psoriasis and metabolic syndrome could help to restore the normal lipid profile.
C1 [Skroza, N.; Proietti, I.; Bernardini, N.; La Viola, G.; Nicolucci, F.; Pampena, R.; Tolino, E.; Zuber, S.; Mancini, M. T.; Soccodato, V.; Balduzzi, V.; Potenza, C.] Sapienza Univ Rome, Dept Dermatol Daniele Innocenzi, Rome, Italy.
C3 Sapienza University Rome
RP Potenza, C (corresponding author), Sapienza Univ Rome, Dept Dermatol Daniele Innocenzi, Via Firenze, I-04019 Latina, Italy.
EM concetta.potenza@uniroma1.it
RI proietti, ilaria/AAL-9155-2020; Potenza, Concetta/F-4198-2011; skroza,
   nevena/F-3931-2011; Pampena, Riccardo/D-3358-2016
OI Tolino, Ersilia/0000-0001-7861-9338; Potenza,
   Concetta/0000-0002-6300-8697; Proietti, Ilaria/0000-0003-3795-3190;
   Pampena, Riccardo/0000-0002-7699-879X
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NR 10
TC 8
Z9 9
U1 0
U2 9
PU EDIZIONI MINERVA MEDICA
PI TURIN
PA CORSO BRAMANTE 83-85 INT JOURNALS DEPT., 10126 TURIN, ITALY
SN 0392-0488
EI 1827-1820
J9 GIORN ITAL DERMAT V
JI G. Ital. Dermatol. Venereol.
PD DEC
PY 2013
VL 148
IS 6
BP 661
EP 665
PG 5
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA AC0NR
UT WOS:000332192500014
PM 24442048
DA 2025-06-11
ER

PT J
AU Black, CN
   Bot, M
   Scheffer, PG
   Penninx, BWJH
AF Black, Catherine N.
   Bot, Mariska
   Scheffer, Peter G.
   Penninx, Brenda W. J. H.
TI Sociodemographic and Lifestyle Determinants of Plasma Oxidative Stress
   Markers 8-OHdG and F2-Isoprostanes and Associations with Metabolic
   Syndrome
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Article
ID BODY-MASS INDEX; DNA-DAMAGE; RISK-FACTORS; CARDIOVASCULAR-DISEASE;
   PHYSICAL-ACTIVITY; BIOMARKERS; F-2-ISOPROSTANES; SMOKING; DEPRESSION;
   EXCRETION
AB Background. Oxidative stress is increasingly important in health research. Therefore, it is necessary to understand which factors determine basal oxidative stress. This study examines the associations of various determinants with markers of oxidative DNA and lipid damage: 8-hydroxy-2'-deoxyguanosine (8-OHdG) and F2-isoprostanes. Methods. Data are from the Netherlands Study of Depression and Anxiety; 1117 subjects (18-65 years) without a current psychiatric diagnosis. Multivariable regression analyses were conducted with plasma levels of 8-OHdG and F2-isoprostanes (measured by LC/MS-MS) including sociodemographic, lifestyle, and sampling variables. Associations with metabolic syndrome (MetS) and chronic disease were examined. Results. 8-OHdG and F2-isoprostanes were weakly correlated (r = 0.06, p = 0.045). Both were positively associated with age and cotinine (cigarette exposure); 8-OHdG was lower in females and after longer sample storage. F2-isoprostanes were higher in females, alcohol users, and in samples collected in spring and lower in supplement users and those with more education. Both markers were lower in fasting subjects. F2-isoprostanes, not 8-OHdG, were positively associated with MetS. Conclusion. The weak correlation between 8-OHdG and F2-isoprostanes suggests they reflect specific aspects of oxidative stress. Both markers are associated with a range of sociodemographic, lifestyle, and sampling determinants which should be considered in future research. F2-isoprostanes are associated with MetS.
C1 [Black, Catherine N.; Bot, Mariska; Penninx, Brenda W. J. H.] Vrije Univ Amsterdam Med Ctr, Dept Psychiat, POB 74077, NL-1070 BB Amsterdam, Netherlands.
   [Black, Catherine N.; Bot, Mariska; Penninx, Brenda W. J. H.] Vrije Univ Amsterdam Med Ctr, EMGO Inst Hlth & Care Res, POB 74077, NL-1070 BB Amsterdam, Netherlands.
   [Black, Catherine N.; Bot, Mariska; Penninx, Brenda W. J. H.] GGZ inGeest, POB 74077, NL-1070 BB Amsterdam, Netherlands.
   [Scheffer, Peter G.] Vrije Univ Amsterdam Med Ctr, Dept Clin Chem, NL-1070 BB Amsterdam, Netherlands.
C3 Vrije Universiteit Amsterdam; VU UNIVERSITY MEDICAL CENTER; Vrije
   Universiteit Amsterdam; VU UNIVERSITY MEDICAL CENTER; Vrije Universiteit
   Amsterdam; VU UNIVERSITY MEDICAL CENTER
RP Black, CN (corresponding author), Vrije Univ Amsterdam Med Ctr, Dept Psychiat, POB 74077, NL-1070 BB Amsterdam, Netherlands.; Black, CN (corresponding author), Vrije Univ Amsterdam Med Ctr, EMGO Inst Hlth & Care Res, POB 74077, NL-1070 BB Amsterdam, Netherlands.; Black, CN (corresponding author), GGZ inGeest, POB 74077, NL-1070 BB Amsterdam, Netherlands.
EM c.black@ggzingeest.nl
RI Penninx, Brenda/S-7627-2017
FU NWO-VICI Grant [91811602]; Geestkracht program of the Netherlands
   Organization for Health Research and Development (Zon-Mw) [10-000-1002];
   VU University Medical Center; Leiden University Medical Center;
   University Medical Center Groningen
FX The authors would like to thank Jan Nouta and acknowledge his
   contribution to the determining of plasma 8-OHdG levels in this study.
   Catherine N. Black and Brenda W. J. H. Penninx are supported by a
   NWO-VICI Grant (no. 91811602). The infrastructure for the NESDA study
   (http://www.nesda.nl/) has been funded through the Geestkracht program
   of the Netherlands Organization for Health Research and Development
   (Zon-Mw, Grant no. 10-000-1002) and participating universities (VU
   University Medical Center, Leiden University Medical Center, and
   University Medical Center Groningen).
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NR 50
TC 56
Z9 60
U1 0
U2 14
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PY 2016
VL 2016
AR 7530820
DI 10.1155/2016/7530820
PG 10
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Cell Biology
GA DK9YK
UT WOS:000375287900001
PM 27006748
OA Green Published, Green Submitted, hybrid
DA 2025-06-11
ER

PT J
AU Lamers, F
   de Jonge, P
   Nolen, WA
   Smit, JH
   Zitman, FG
   Beekman, ATF
   Penninx, BWJH
AF Lamers, Femke
   de Jonge, Peter
   Nolen, Willem A.
   Smit, Johannes H.
   Zitman, Frans G.
   Beekman, Aartjan T. F.
   Penninx, Brenda W. J. H.
TI Identifying Depressive Subtypes in a Large Cohort Study: Results From
   the Netherlands Study of Depression and Anxiety (NESDA)
SO JOURNAL OF CLINICAL PSYCHIATRY
LA English
DT Article
ID ATYPICAL DEPRESSION; MAJOR DEPRESSION; SYMPTOMATOLOGY IDS; MOOD
   DISORDERS; DSM-V; VALIDATION; SYMPTOMS; CLASSIFICATION; COMORBIDITY;
   HYPOTHESIS
AB Objective: The heterogeneity of depression in the current classification system remains a point of discussion in the psychiatric field, despite previous efforts to subclassify depressive disorders. Data-driven techniques may help to come to a more empirically based classification. This study aimed to identify depressive subtypes within a large cohort of subjects with depression.
   Method: Baseline data from 818 persons with a DSM-IV diagnosis of current major depressive disorder or minor depression who participated in the Netherlands Study of Depression and Anxiety were used. Respondents were recruited in the community, in primary care, and in specialized mental health care from September 2004 through February 2007. Latent classes were derived from latent class analysis using 16 depressive symptoms from the Composite International Diagnostic Interview and the Inventory of Depressive Symptomatology. Classes were characterized using demographic, clinical psychiatric, psychosocial, and physical health descriptors.
   Results: Three classes were identified: a severe melancholic class (prevalence, 46.3%), a severe atypical class (prevalence, 24.6%), and a class of moderate severity (prevalence, 29.1%). Both severe classes were characterized by more neuroticism (melancholic OR=1.05 [95% CI, 1.01-1.10]; atypical OR=1.07 [95% Cl, 1.03-1.12]), more disability (melancholic OR=1.07 [95% Cl, 1.05-1.09]; atypical OR=1.06 [95% CI, 1.04-1.07]), and less extraversion (melancholic OR=0.95 [95% CI, 0.92-0.99]; atypical OR=0.95 [95% CI, 0.92-0.99] than the moderate class. Comparing the melancholic class with the atypical class revealed that the melancholic class had more smokers (atypical OR=0.57 [95% CI, 0.39-0.84]) and more childhood trauma (atypical OR=0.86 [95% CI, 0.74-1.00]), whereas the atypical class had more women (atypical OR=1.52 [95% CI, 0.99-2.32]), a higher body mass index (atypical OR=1.13 [95% CI, 1.09-1.17]), and more metabolic syndrome (atypical OR=2.17 [95% CI, 1.38-3.42]).
   Conclusions: Both depression severity (moderate vs severe) and the nature of depressive symptoms (melancholic vs atypical) were found to be important differentiators between subtypes. Higher endorsement rates of somatic symptoms and more metabolic syndrome in the atypical class suggest the involvement of a metabolic component. J Clin Psychiatry 2010;71(12):1582-1589 (C) Copyright 2010 Physicians Postgraduate Press, Inc.
C1 [Lamers, Femke; Smit, Johannes H.; Beekman, Aartjan T. F.; Penninx, Brenda W. J. H.] VU Univ Med Ctr Amsterdam, Dept Psychiat, NL-1081 HL Amsterdam, Netherlands.
   [Lamers, Femke; Smit, Johannes H.; Beekman, Aartjan T. F.; Penninx, Brenda W. J. H.] VU Univ Med Ctr Amsterdam, EMGO Inst Hlth & Care Res, NL-1081 HL Amsterdam, Netherlands.
   [de Jonge, Peter; Nolen, Willem A.; Penninx, Brenda W. J. H.] Univ Groningen, Dept Psychiat, NL-9700 AB Groningen, Netherlands.
   [de Jonge, Peter] Univ Groningen, Dept Internal Med, Univ Med Ctr Groningen, NL-9700 AB Groningen, Netherlands.
   [de Jonge, Peter] Tilburg Univ, Ctr Res Psychol Somat Dis, Dept Med Psychol, NL-5000 LE Tilburg, Netherlands.
   [Zitman, Frans G.; Penninx, Brenda W. J. H.] Leiden Univ, Med Ctr, Dept Psychiat, Leiden, Netherlands.
C3 Vrije Universiteit Amsterdam; VU UNIVERSITY MEDICAL CENTER; Vrije
   Universiteit Amsterdam; VU UNIVERSITY MEDICAL CENTER; University of
   Groningen; University of Groningen; Tilburg University; Leiden
   University - Excl LUMC; Leiden University; Leiden University Medical
   Center (LUMC)
RP Lamers, F (corresponding author), VU Univ Med Ctr Amsterdam, Dept Psychiat, AJ Ernststr 887, NL-1081 HL Amsterdam, Netherlands.
EM f.lamers@vumc.nl
RI Lamers, Femke/G-5161-2012; Nolen, Willem/E-9006-2014; Zitman,
   Frans/E-7705-2010; Penninx, Brenda/S-7627-2017; Beekman, Aartjan
   T./LUZ-6919-2024; Sundström, Johan/IAP-6197-2023; de Jonge,
   Peter/L-6395-2013
OI de Jonge, Peter/0000-0002-0866-6929; Lamers, Femke/0000-0003-4344-5766
FU Netherlands Organization for Health Research and Development; European
   Union; Stanley Medical Research Institute; AstraZeneca; Eli Lilly;
   GlaxoSmithKline; Wyeth; Pfizer; Servier; Netherlands Organization for
   Health Research and Development (ZonMw) [10-000-1002]; VU University
   Medical Center; GGZ inGeest; Arkin; Leiden University Medical Center;
   GGZ Rivierduinen; University Medical Center Groningen; Lentis; GGZ
   Friesland; GGZ Drenthe; IQ Healthcare; Netherlands Institute for Health
   Services Research (NIVEL); Netherlands Institute of Mental Health and
   Addiction (Trimbos)
FX Dr Nolen has received grants from the Netherlands Organization for
   Health Research and Development, European Union, Stanley Medical
   Research Institute, AstraZeneca, Eli Lilly, GlaxoSmithKline, and Wyeth;
   has received honoraria or speaker fees from AstraZeneca, Eli Lilly,
   Pfizer, Servier, and Wyeth; and has been an advisory board member for
   AstraZeneca, Cyberonics, Pfizer, and Servier. Drs Lamers, de Jonge,
   Smit, Zitman, Beekman, and Penninx report no financial or other
   relationships relevant to the subject of this article.The infrastructure
   for the Netherlands Study of Depression and Anxiety (NESDA)
   (www.nesda.nl) is funded through the Geestkracht program of the
   Netherlands Organization for Health Research and Development (ZonMw,
   grant number 10-000-1002) and is supported by participating universities
   and mental health care organizations: VU University Medical Center, GGZ
   inGeest, Arkin, Leiden University Medical Center, GGZ Rivierduinen,
   University Medical Center Groningen, Lentis, GGZ Friesland, GGZ Drenthe,
   IQ Healthcare, Netherlands Institute for Health Services Research
   (NIVEL), and the Netherlands Institute of Mental Health and Addiction
   (Trimbos).
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NR 49
TC 218
Z9 232
U1 1
U2 65
PU PHYSICIANS POSTGRADUATE PRESS
PI MEMPHIS
PA P O BOX 752870, MEMPHIS, TN 38175-2870 USA
SN 0160-6689
EI 1555-2101
J9 J CLIN PSYCHIAT
JI J. Clin. Psychiatry
PD DEC
PY 2010
VL 71
IS 12
BP 1582
EP 1589
DI 10.4088/JCP.09m05398blu
PG 8
WC Psychology, Clinical; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA 707OO
UT WOS:000286296100003
PM 20673552
DA 2025-06-11
ER

PT J
AU Wingo, AP
   Gibson, G
AF Wingo, Aliza P.
   Gibson, Greg
TI Blood gene expression profiles suggest altered immune function
   associated with symptoms of generalized anxiety disorder
SO BRAIN BEHAVIOR AND IMMUNITY
LA English
DT Article
DE Anxiety; Generalized anxiety disorder; Gene expression; Genome-wide
   differential gene expression; Immune function; Modules of co-regulated
   transcripts
ID CORONARY-HEART-DISEASE; BODY-MASS INDEX; PSYCHOLOGICAL STRESS;
   ANTIBODY-RESPONSE; INFLUENZA; VACCINATION; MODULATION; GENOMICS; RISK
AB Prospective epidemiological studies found that generalized anxiety disorder (GAD) can impair immune function and increase risk for cardiovascular disease or events. Mechanisms underlying the physiological reverberations of anxiety, however, are still elusive. Hence, we aimed to investigate molecular processes mediating effects of anxiety on physical health using blood gene expression profiles of 336 community participants (157 anxious and 179 control). We examined genome-wide differential gene expression in anxiety, as well as associations between nine major modules of co-regulated transcripts in blood gene expression and anxiety. No significant differential expression was observed in women, but 631 genes were differentially expressed between anxious and control men at the false discovery rate of 0.1 after controlling for age, body mass index, race, and batch effect. Gene set enrichment analysis (GSEA) revealed that genes with altered expression levels in anxious men were involved in response of various immune cells to vaccination and to acute viral and bacterial infection, and in a metabolic network affecting traits of metabolic syndrome. Further, we found one set of 260 co-regulated genes to be significantly associated with anxiety in men after controlling for the relevant covariates, and demonstrate its equivalence to a component of the stress-related conserved transcriptional response to adversity profile. Taken together, our results suggest potential molecular pathways that can explain negative effects of GAD observed in epidemiological studies. Remarkably, even mild anxiety, which most of our participants had, was associated with observable changes in immune-related gene expression levels. Our findings generate hypotheses and provide incremental insights into molecular mechanisms mediating negative physiological effects of GAD. Published by Elsevier Inc.
C1 [Wingo, Aliza P.] Atlanta VA Med Ctr, Decatur, GA 30033 USA.
   [Wingo, Aliza P.] Emory Univ, Sch Med, Dept Psychiat & Behav Sci, Atlanta, GA 30322 USA.
   [Gibson, Greg] Georgia Inst Technol, Ctr Integrat Genom, Sch Biol, Atlanta, GA 30332 USA.
C3 US Department of Veterans Affairs; Veterans Health Administration (VHA);
   Atlanta VA Health Care System; Atlanta VA Medical Center; Emory
   University; University System of Georgia; Georgia Institute of
   Technology
RP Gibson, G (corresponding author), Georgia Inst Technol, Boggs 34334, Atlanta, GA 30332 USA.
EM greg.gibson@biology.gatech.edu
OI Wingo, Aliza/0000-0002-6360-6726
FU Department of Veterans Affairs Career Development Award [IK2CX000601];
   NARSAD; Georgia Tech Research Institute; NIH [P01GM099568]
FX This study was supported in part by the Department of Veterans Affairs
   Career Development Award number IK2CX000601 and the NARSAD Young
   Investigator Award (to APW). The contents do not represent the views of
   the Department of Veterans Affairs or the United States Government. Gene
   expression data was generated with start-up funds to GG from the Georgia
   Tech Research Institute, and phenotypic data for the CHDWB was generated
   with support from the Emory University School of Medicine. GG is also
   supported by the NIH award P01GM099568 (Project 3).
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NR 45
TC 41
Z9 42
U1 2
U2 24
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0889-1591
EI 1090-2139
J9 BRAIN BEHAV IMMUN
JI Brain Behav. Immun.
PD JAN
PY 2015
VL 43
BP 184
EP 191
DI 10.1016/j.bbi.2014.09.016
PG 8
WC Immunology; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Neurosciences & Neurology; Psychiatry
GA CQ4RQ
UT WOS:000360592700022
PM 25300922
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Eriksson, MD
   Eriksson, JG
   Kautiainen, H
   Salonen, MK
   Mikkola, TM
   Kajantie, E
   Wasenius, N
   von Bonsdorff, M
   Laine, MK
AF Eriksson, Mia D.
   Eriksson, Johan G.
   Kautiainen, Hannu
   Salonen, Minna K.
   Mikkola, Tuija M.
   Kajantie, Eero
   Wasenius, Niko
   von Bonsdorff, Mikaela
   Laine, Merja K.
TI Advanced glycation end products measured by skin autofluorescence are
   associated with melancholic depressive symptoms - Findings from Helsinki
   Birth Cohort Study
SO JOURNAL OF PSYCHOSOMATIC RESEARCH
LA English
DT Article
DE Advanced glycation end products; Biomarkers; Cohort studies;
   Comorbidity; Depression; Depressive disorder; Inflammation
ID ARTERIAL STIFFNESS; METABOLIC SYNDROME; OXIDATIVE STRESS; MENTAL-HEALTH;
   LIFE-STYLE; POPULATION; DISEASE; RISK; PREVALENCE; DISORDERS
AB Background: Millions of people live with depression and its burden of disease. Depression has an increased comorbidity and mortality that has remained unexplained. Studies have reported connections between advanced glycation end products (AGEs) and various disease processes, including mental health. The present study evaluated associations between AGEs, depressive symptoms, and types of depressive symptoms.
   Methods: From the Helsinki Birth Cohort Study, 815 participants with a mean age of 76 years were recruited for this cross-sectional study. Characteristics regarding self-reported lifestyle and medical history, as well as blood tests were obtained along with responses regarding depressive symptoms according to the Beck Depression Inventory (BDI) and Mental Health Inventory-5. Each participant had their AGE level measured non-invasively with skin autofluorescence (SAF). Statistical analyses looked at relationships between types of depressive symptoms and AGE levels by sex.
   Results: Of women, 27% scored >= 10 on the BDI and 18% of men, respectively. Men had higher crude AGE levels (mean [standard deviation], arbitrary units) (2.49 [0.51]) compared to women (2.33 [0.46]) (p < 0.001). The highest crude AGE levels were found in those with melancholic depressive symptoms (2.61 [0.57]), followed by those with non-melancholic depressive symptoms (2.45 [0.45]) and those with no depressive symptoms (2.38 [0.49]) (p = 0.013). These findings remained significant in the fully adjusted model.
   Conclusions: The current study shows an association between depressive symptoms and higher AGE levels. The association is likely part of a multi-factorial effect, and hence no directionality, causality, or effect can be inferred solely based on the results of this study.
C1 [Eriksson, Mia D.] Helsinki Univ Hosp HUS, Primary Hlth Care Unit, Helsinki, Finland.
   [Eriksson, Mia D.; Eriksson, Johan G.; Kautiainen, Hannu; Salonen, Minna K.; Mikkola, Tuija M.; Wasenius, Niko; von Bonsdorff, Mikaela; Laine, Merja K.] Folkhalsan Res Ctr, Helsinki, Finland.
   [Eriksson, Johan G.; Kautiainen, Hannu; Wasenius, Niko; Laine, Merja K.] Univ Helsinki, Dept Gen Practice & Primary Hlth Care, Helsinki, Finland.
   [Eriksson, Johan G.; Kautiainen, Hannu; Wasenius, Niko; Laine, Merja K.] Helsinki Univ Hosp, Helsinki, Finland.
   [Eriksson, Johan G.; Kautiainen, Hannu] Natl Univ Singapore, Dept Obstet & Gynecol, Human Potential Translat Res Programme, Yong Loo Lin Sch Med, Singapore, Singapore.
   [Eriksson, Johan G.; Kautiainen, Hannu] ASTAR, Singapore Inst Clin Sci SICS, Singapore, Singapore.
   [Kautiainen, Hannu] Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland.
   [Salonen, Minna K.; Kajantie, Eero] Finnish Inst Hlth & Welf, Publ Hlth Promot Unit, Dept Publ Hlth Solut, Helsinki, Finland.
   [Mikkola, Tuija M.] Univ Helsinki, Clinicum, Fac Med, Helsinki, Finland.
   [Kajantie, Eero] Oulu Univ Hosp, MRC Oulu, PEDEGO Res Unit, Oulu, Finland.
   [Kajantie, Eero] Univ Oulu, Oulu, Finland.
   [Kajantie, Eero] Norwegian Univ Sci & Technol, Dept Clin & Mol Med, Trondheim, Norway.
   [von Bonsdorff, Mikaela] Univ Jyvaskyla, Fac Sport & Hlth Sci, Gerontol Res Ctr, Jyvaskyla, Finland.
C3 Folkhalsan Research Center; University of Helsinki; University of
   Helsinki; Helsinki University Central Hospital; National University of
   Singapore; Agency for Science Technology & Research (A*STAR); A*STAR -
   Singapore Institute for Clinical Sciences (SICS); University of Eastern
   Finland; University of Helsinki; University of Oulu; University of Oulu;
   Norwegian University of Science & Technology (NTNU); University of
   Jyvaskyla
RP Eriksson, MD (corresponding author), Helsinki Univ Hosp HUS, Primary Hlth Care Unit, Helsinki, Finland.; Eriksson, MD (corresponding author), Folkhalsan Res Ctr, Helsinki, Finland.
EM mia.eriksson@tcu.edu
RI Wasenius, Niko/AAE-8927-2020; Gibbs, J. Raphael/A-3984-2010; Mikkola,
   Tuija/L-2835-2014; /H-8100-2016; von Bonsdorff, Mikaela/A-5218-2015
OI Eriksson, Mia/0000-0001-8968-8304; Mikkola, Tuija/0000-0003-0885-2788;
   /0000-0002-1848-1514; von Bonsdorff, Mikaela/0000-0001-8530-5230;
   Wasenius, Niko/0000-0002-9007-6660
FU Finska Lakaresallskapet; Finnish Special Governmental Subsidy for Health
   Sciences; Academy of Finland [126775, 127437, 129255, 129306, 129907,
   130326, 134791, 209072, 210595, 213225, 263924, 275074, 315690];
   Samfundet Folkhalsan; Liv och Halsa; EU FP7 [Developmental Origins of
   Healthy Aging (DORIAN)] [278603]; EU H2020-PHC-2014-DynaHealth grant
   [633595]; EU Horizon 2020 Award [733206]; European Commission,
   Horizon2020 award [733280]; Foundation for Cardiovascular Research;
   Foundation for Diabetes Research; Foundation for Pediatric Research;
   Novo Nordisk Foundation; Signe and Ane Gyllenberg Foundation; Academy of
   Finland (AKA) [275074, 213225, 210595, 209072] Funding Source: Academy
   of Finland (AKA)
FX The HBCS has been supported by grants from Finska Lakaresallskapet, the
   Finnish Special Governmental Subsidy for Health Sciences, Academy of
   Finland (126775, 127437, 129255, 129306, 129907, 130326, 134791, 209072,
   210595, 213225, 263924, 275074 and 315690), Samfundet Folkhalsan, Liv
   och Halsa, EU FP7 [Developmental Origins of Healthy Aging (DORIAN)]
   project number 278603, and EU H2020-PHC-2014-DynaHealth grant 633595 and
   EU Horizon 2020 Award 733206 LIFECYCLE (all for the Helsinki Birth
   Cohort Study), European Commission, Horizon2020 award 733280 RECAP),
   Foundation for Cardiovascular Research, Foundation for Diabetes
   Research, Foundation for Pediatric Research, Novo Nordisk Foundation,
   Signe and Ane Gyllenberg Foundation.
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NR 45
TC 9
Z9 9
U1 0
U2 1
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-3999
EI 1879-1360
J9 J PSYCHOSOM RES
JI J. Psychosomat. Res.
PD JUN
PY 2021
VL 145
AR 110488
DI 10.1016/j.jpsychores.2021.110488
EA MAY 2021
PG 7
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA SA1HZ
UT WOS:000649050200045
PM 33863506
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Soares, NP
   dos Santos, ACS
   Costa, EC
   Azevedo, GD
   Damasceno, DC
   Fayh, APT
   Lemos, TMAM
AF Soares, Nayara Pereira
   Souza dos Santos, Ana Celly
   Costa, Eduardo Caldas
   Azevedo, George Dantas
   Damasceno, Debora Cristina
   Trussardi Fayh, Ana Paula
   Araujo Moura Lemos, Telma Maria
TI Diet-Induced Weight Loss Reduces DNA Damage and Cardiometabolic Risk
   Factors in Overweight/Obese Women with Polycystic Ovary Syndrome
SO ANNALS OF NUTRITION AND METABOLISM
LA English
DT Article
DE Diet; DNA damage; Cardiometabolic risk factors; Overweight; Obesity;
   Polycystic ovary syndrome
ID OXIDATIVE STRESS; INSULIN-RESISTANCE; METABOLIC SYNDROME; ANTHROPOMETRIC
   INDEXES; BRAZILIAN WOMEN; BODY-MASS; PREVALENCE; RESTRICTION; BLOOD;
   LYMPHOCYTES
AB Aims: We aimed to investigate the impact of following a diet to induce weight loss (500 kcal deficit per day) over DNA damage and cardiometabolic risk factors in women with overweight/obesity diagnosed with polycystic ovary syndrome (PCOS). Methods: A study was conducted in Natal, RN, Brazil selecting overweight/obese (body mass index >= 25 and <39 kg/m(2)) women (18-35 years). The levels of DNA damage were assessed by a single cell gel electrophoresis. Repeated 24 h dietary recall questionnaires, anthropometry, biochemical profile and sex hormones were collected at baseline and after 12 weeks of intervention. Results: Women exhibiting a decrease in the markers of DNA damage: tail intensity (24.35 +/- 5.86 - pre diet vs. 17.15 +/- 5.04 - post-diet; p < 0.001) and tail moment (20.47 +/- 7.85 - pre diet vs. 14.13 +/- 6.29 - post-diet; p < 0.002). Reduction of calorie intake, weight loss, decreased sexual hormone and cardiometabolic markers such as insulin, homeostasis model assessment of insulin resistance and low-density lipoprotein cholesterol were verified In the multivariate regression analysis, quantitative insulin sensitivity check index and progesterone were responsible for the variation markers in DNA damage before the diet, losing its influence upon diet. Conclusion: DNA damage and the impact of cardiometabolic risk factors decreased after the intervention in women with PCOS, indicating the relevance of a nutritional approach in this group of patients. (C) 2016 S. Karger AG, Basel
C1 [Soares, Nayara Pereira; Souza dos Santos, Ana Celly; Araujo Moura Lemos, Telma Maria] Univ Fed Rio Grande do Norte, Dept Clin & Toxicol, BR-59010180 Natal, RN, Brazil.
   [Costa, Eduardo Caldas] Univ Fed Rio Grande do Norte, Dept Phys Educ, BR-59010180 Natal, RN, Brazil.
   [Azevedo, George Dantas] Univ Fed Rio Grande do Norte, Dept Morphol, BR-59010180 Natal, RN, Brazil.
   [Trussardi Fayh, Ana Paula] Univ Fed Rio Grande do Norte, Dept Nutr, BR-59010180 Natal, RN, Brazil.
   [Damasceno, Debora Cristina] Sao Paulo State Univ, Dept Gynecol & Obstet, Botucatu Sch Med, Sao Paulo, Brazil.
C3 Universidade Federal do Rio Grande do Norte; Universidade Federal do Rio
   Grande do Norte; Universidade Federal do Rio Grande do Norte;
   Universidade Federal do Rio Grande do Norte; Universidade Estadual
   Paulista
RP Soares, NP (corresponding author), Univ Fed Rio Grande do Norte, Fac Farm, Dept Anal Clin & Toxicol, Rua Gen Cordeiro Petropolis, BR-59010180 Natal, RN, Brazil.
EM nayara.pereirasoares@gmail.com
RI ; Damasceno, Debora Cristina/C-7234-2012; Caldas Costa,
   Eduardo/X-7891-2018
OI LEMOS, TELMA/0000-0001-7118-2145; Damasceno, Debora
   Cristina/0000-0002-7003-9643; Caldas Costa, Eduardo/0000-0003-2807-7109
FU Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq);
   Ministerio da Saude do Brasil; Fundacao de Apoio a Pesquisa do Estado do
   Rio Grande do Norte
FX This study was supported by the Conselho Nacional de Desenvolvimento
   Cientifico e Tecnologico (CNPq), Ministerio da Saude do Brasil, and
   Fundacao de Apoio a Pesquisa do Estado do Rio Grande do Norte. The
   authors are very grateful to Rafael B. Gelaleti and Aline O. Netto for
   support in the DNA damage analysis.
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NR 60
TC 22
Z9 26
U1 0
U2 10
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0250-6807
EI 1421-9697
J9 ANN NUTR METAB
JI Ann. Nutr. Metab.
PY 2016
VL 68
IS 3
BP 220
EP 227
DI 10.1159/000444130
PG 8
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA DL7EP
UT WOS:000375803700009
PM 27073909
OA Green Published
DA 2025-06-11
ER

PT J
AU Marrone, G
   Urciuoli, S
   Di Lauro, M
   Cornali, K
   Montalto, G
   Masci, C
   Vanni, G
   Tesauro, M
   Vignolini, P
   Noce, A
AF Marrone, Giulia
   Urciuoli, Silvia
   Di Lauro, Manuela
   Cornali, Kevin
   Montalto, Giulia
   Masci, Claudia
   Vanni, Gianluca
   Tesauro, Manfredi
   Vignolini, Pamela
   Noce, Annalisa
TI Saffron (Crocus sativus L.) and Its By-Products: Healthy Effects
   in Internal Medicine
SO NUTRIENTS
LA English
DT Review
DE circular economy; Crocus sativus L.; by-products; natural bioactive
   compounds; metabolic syndrome; chronic kidney diseases; depression
ID METABOLIC SYNDROME; OXIDATIVE STRESS; EXTRACT; IDENTIFICATION; CROCETIN;
   STIGMAS; GLUCOSE; SUPPLEMENTATION; INFLAMMATION; SENSITIVITY
AB Crocus sativus L., commonly known as saffron, is a precious spice coming from Asia, in particular from Iran, the country leader in its production. The spice is derived exclusively from dried stigmas and it is the most expensive one in the world. The areas of application of saffron are multiple, in fact ranging across the food, drinks, pharmaceuticals and cosmetics sectors. As is the case with other phytochemicals, not only the final product but also saffron by-products are considered a valuable source of bioactive natural compounds. In fact, its healthy effects, especially as antioxidants and anti-inflammatories (via reducing pro-inflammatory cytokines), are well-recognized in internal medicine. In particular, its healthy effects are related to counteracting degenerative maculopathy, depression and anxiety, neurodegenerative diseases, metabolic syndrome, cancer and chronic kidney disease, by promoting glucose metabolism. In this review, we summarize the most important papers in which saffron has turned out to be a valuable ally in the prevention and treatment of these pathologies. Moreover, we would like to promote the use of saffron by-products as part of a bio-circular economy system, aimed at reducing wastes, at maximizing the use of resources and at promoting environmental and economic sustainability.
C1 [Marrone, Giulia; Di Lauro, Manuela; Cornali, Kevin; Masci, Claudia; Tesauro, Manfredi; Noce, Annalisa] Univ Roma Tor Vergata, Dept Syst Med, Gastroenterol Unit, I-00133 Rome, Italy.
   [Urciuoli, Silvia; Vignolini, Pamela] Univ Florence, Dept Stat Comp Sci Applicat Giuseppe Parenti DiSIA, PHYTOLAB Lab Pharmaceut Cosmet Food Supplement Tec, Via Ugo Schiff 6, I-50019 Florence, Italy.
   [Montalto, Giulia] Univ Roma Tor Vergata, Sch Specializat Nephrol, I-00133 Rome, Italy.
   [Vanni, Gianluca] Tor Vergata Univ, Dept Surg Sci, Breast Unit Policlin Tor Vergata, Viale Oxford 81, I-00133 Rome, Italy.
   [Noce, Annalisa] Policlin Tor Vergata, Nephrol & Dialysis Unit, I-00133 Rome, Italy.
C3 University of Rome Tor Vergata; University of Florence; University of
   Rome Tor Vergata; University of Rome Tor Vergata; University of Rome Tor
   Vergata; Policlin Tor Vergata
RP Cornali, K; Noce, A (corresponding author), Univ Roma Tor Vergata, Dept Syst Med, Gastroenterol Unit, I-00133 Rome, Italy.; Noce, A (corresponding author), Policlin Tor Vergata, Nephrol & Dialysis Unit, I-00133 Rome, Italy.
EM giulia.marrone@uniroma2.it; silvia.urciuoli@unifi.it;
   dilauromanuela@gmail.com; cornali.kevin@hotmail.it;
   giulia.montalto@ptvonline.it; masciclaudia@gmail.com;
   vanni_gianluca@yahoo.it; mtesauro@tiscali.it; pamela.vignolini@unifi.it;
   annalisa.noce@uniroma2.it
RI Marrone, Giulia/IQR-7760-2023; Di Lauro, Manuela/AAB-9784-2022; Noce,
   Annalisa/B-5558-2019; Vanni, Gianluca/AAJ-9743-2020
OI Di Lauro, Manuela/0000-0001-8118-1330; NOCE,
   ANNALISA/0000-0003-1310-3730; VIGNOLINI, PAMELA/0000-0002-9500-7971;
   Marrone, Giulia/0000-0002-5854-2086; vanni,
   gianluca/0000-0002-3006-5855; URCIUOLI, SILVIA/0000-0001-8139-3229;
   Cornali, Kevin/0009-0004-8904-4399; , Giulia
   Montalto/0009-0004-3501-6894
FX We would like to thank Rome Technopole spoke V for the scientific
   support and the Cassa di Risparmio Firenze Foundation-Call for
   Researchers in Florence 2023 edition-Molecules Project.
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NR 115
TC 8
Z9 8
U1 1
U2 8
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JUL
PY 2024
VL 16
IS 14
AR 2319
DI 10.3390/nu16142319
PG 17
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA ZX7I6
UT WOS:001278646300001
PM 39064764
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Milaneschi, Y
   Lamers, F
   Berk, M
   Penninx, BWJH
AF Milaneschi, Yuri
   Lamers, Femke
   Berk, Michael
   Penninx, Brenda W. J. H.
TI Depression Heterogeneity and Its Biological Underpinnings: Toward
   Immunometabolic Depression
SO BIOLOGICAL PSYCHIATRY
LA English
DT Review
DE Depression; Heterogeneity; Homeostasis; Inflammation; Metabolism;
   Treatment
ID C-REACTIVE PROTEIN; BODY-MASS INDEX; MAJOR DEPRESSION; ATYPICAL
   DEPRESSION; METABOLIC SYNDROME; ABDOMINAL OBESITY; METAANALYSIS;
   ASSOCIATION; LEPTIN; ANXIETY
AB Epidemiological evidence indicates the presence of dysregulated homeostatic biological pathways in depressed patients, such as increased inflammation and disrupted energy-regulating neuroendocrine signaling (e.g., leptin, insulin). Alterations in these biological pathways may explain the considerable comorbidity between depression and cardiometabolic conditions (e.g., obesity, metabolic syndrome, diabetes) and represent a promising target for intervention. This review describes how immunometabolic dysregulations vary as a function of depression hetero-geneity by illustrating that such biological dysregulations map more consistently to atypical behavioral symptoms reflecting altered energy intake/expenditure balance (hyperphagia, weight gain, hypersomnia, fatigue, and leaden paralysis) and may moderate the antidepressant effects of standard or novel (e.g., anti-inflammatory) therapeutic approaches. These lines of evidence are integrated in a conceptual model of immunometabolic depression emerging from the clustering of immunometabolic biological dysregulations and specific behavioral symptoms. The review finally elicits questions to be answered by future research and describes how the immunometabolic depression dimension could be used to dissect the heterogeneity of depression and potentially to match subgroups of patients to specific treatments with higher likelihood of clinical success.
C1 [Milaneschi, Yuri; Lamers, Femke; Penninx, Brenda W. J. H.] Vrije Univ, Amsterdam Univ, Med Ctr, Amsterdam Publ Hlth,Dept Psychiat, Amsterdam, Netherlands.
   [Milaneschi, Yuri; Lamers, Femke; Penninx, Brenda W. J. H.] Vrije Univ, Amsterdam Univ, Med Ctr, Amsterdam Neurosci, Amsterdam, Netherlands.
   [Milaneschi, Yuri; Lamers, Femke; Penninx, Brenda W. J. H.] GGZinGeest, Amsterdam, Netherlands.
   [Berk, Michael] Deakin Univ, Sch Med, Inst Mental & Phys Hlth & Clin Treatment, Geelong, Vic, Australia.
   [Berk, Michael] Barwon Hlth, Geelong, Vic, Australia.
   [Berk, Michael] Univ Melbourne, Dept Psychiat, Natl Ctr Excellence Youth Mental Hlth, Orygen, Melbourne, Vic, Australia.
   [Berk, Michael] Univ Melbourne, Florey Inst Neurosci & Mental Hlth, Melbourne, Vic, Australia.
C3 Vrije Universiteit Amsterdam; University of Amsterdam; Vrije
   Universiteit Amsterdam; University of Amsterdam; Deakin University;
   Barwon Health; University of Melbourne; Orygen, The National Centre of
   Excellence in Youth Mental Health; Florey Institute of Neuroscience &
   Mental Health; University of Melbourne
RP Milaneschi, Y (corresponding author), Vrije Univ, GGZ inGeest, Amsterdam UMC, Dept Psychiat, Oldenaller 1, NL-1081 HJ Amsterdam, Netherlands.
EM y.milaneschi@ggzingeest.nl
RI Berk, Michael/AGH-9427-2022; Lamers, Femke/G-5161-2012; Berk,
   Michael/M-7891-2013; Penninx, Brenda WJH/S-7627-2017
OI Berk, Michael/0000-0002-5554-6946; Penninx, Brenda
   WJH/0000-0001-7779-9672; Milaneschi, Yuri/0000-0002-3697-6617
FU National Health and Medical Research Council Senior Principal Research
   Fellowship [APP1059660, APP1156072]; European Union Seventh Framework
   Programme FP7-Marie Curie Career Integration Grant
   [PCIG12-GA-2012-334065]
FX This work was supported by the National Health and Medical Research
   Council Senior Principal Research Fellowship (Grant Nos. APP1059660 and
   APP1156072 [to MB]) and European Union Seventh Framework Programme
   FP7-Marie Curie Career Integration Grant (Grant No.
   PCIG12-GA-2012-334065 [to FL]).
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NR 113
TC 241
Z9 250
U1 13
U2 157
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0006-3223
EI 1873-2402
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD SEP 1
PY 2020
VL 88
IS 5
BP 369
EP 380
DI 10.1016/j.biopsych.2020.01.014
PG 12
WC Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA ND0MO
UT WOS:000561602700006
PM 32247527
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Demir, B
   Temizhan, A
   Keskin, G
   Baser, K
   Turak, O
   Cay, S
AF Demir, Bulent
   Temizhan, Ahmet
   Keskin, Gokhan
   Baser, Kazim
   Turak, Osman
   Cay, Serkan
TI Comparison of serum gamma-glutamyltransferase levels between patients
   with cardiac syndrome X and healthy asymptomatic individuals
SO KARDIOLOGIA POLSKA
LA English
DT Article
DE cardiac syndrome X; gamma-glutamyltransferase; oxidative stress
ID STABLE ANGINA-PECTORIS; SLOW CORONARY FLOW; METABOLIC SYNDROME;
   OXIDATIVE STRESS; DISEASE; ATHEROSCLEROSIS; RISK
AB Background: Gamma-glutamyltransferase (GGT) enzyme has an increasing importance in the pathophysiology and prognosis of cardiovascular diseases. It is an indirect marker of microvascular endothelial dysfunction, atherosclerosis, and elevated oxidative stress. There are no adequate data on the relationship between GGT and cardiac syndrome X. Aim: To compare serum GGT levels between patients with cardiac syndrome X and asymptomatic healthy individuals.
   Methods: Fifty consecutive patients (29 female, 21 male, aged 28-81 years) who underwent coronary angiography due to objective ischaemia and were eventually diagnosed with cardiac syndrome X between July 2009 and January 2010, and 50 healthy asymptomatic control individuals (28 female, 22 male, aged 30-78 years) were studied. Venous blood samples were collected for GOT measurements. A metabolic syndrome (MS) subgroup composed of 15 individuals was formed within the cardiac syndrome X group.
   Results: Serum total cholesterol, LDL-cholesterol, and triglyceride (TG) levels were significantly higher in the cardiac syndrome X patients than in the control group (195.28 +/- 33.71 mg/dL and 168.82 +/- 31.45 mg/dL, p < 0.01, 121.62 +/- 30.53 mg/dL and 98.44 +/- 27.28 mg/dL, p < 0.01, 144.30 +/- 68.54 mg/dL and 108.94 +/- 43.59 mg/dL, p < 0.01, respectively). Serum GGT levels were also significantly higher in the cardiac syndrome X patients than in the control group (30.48 +/- 16.36 and 17.88 +/- 6. 89 U/L, p < 0.001). The MS patients (n = 15) had significantly higher TG and GGT levels (230.00 +/- 41.37 mg/dL and 107.57 +/- 37.90 mg/dL, p < 0.01, 38.47 +/- 21.27 U/L and 27.06 +/- 12.61 U/L, p < 0.001, respectively) and lower HDL levels (35.47 +/- 6.91 mg/dL and 48.26 +/- 9.97 mg/dL, p < 0.05) compared to patients without MS. The cardiac syndrome X group exhibited a significant positive correlation between GGT and body mass index, and GGT and TG (r = 0.321, p = 0.023, r = 0.293, p = 0.039, respectively).
   Conclusions: GGT activity in patients with cardiac syndrome X was higher than in healthy controls. Moreover, GGT activity was further increased in those patients with cardiac syndrome X who had also MS.
C1 [Cay, Serkan] Haydarpasa Educ Hosp, Gulhane Mil Med Acad, Dept Cardiol, Ankara, Turkey.
   [Demir, Bulent] Doctor Sadi KONUK Educ & Res Hosp, Dept Cardiol, Istanbul, Turkey.
   [Temizhan, Ahmet; Keskin, Gokhan; Baser, Kazim; Turak, Osman] Yuksek Ihtisas Educ & Res Hosp, Dept Cardiol, Ankara, Turkey.
C3 Gulhane Military Medical Academy; Istanbul Haydarpasa Sultan Abdulhamid
   Training & Research Hospital; Turkey Specialized Higher Education &
   Research Hospital; Yuksek Ihtisas Training & Research Hospital
RP Cay, S (corresponding author), Haydarpasa Educ Hosp, Gulhane Mil Med Acad, Dept Cardiol, Yasamkent Mah 3222 Cad 2 Blok Yakut 37 D 27 Cayyo, Ankara, Turkey.
EM cayserkan@yahoo.com
RI Demir, Bulent/KVC-1688-2024; Temizhan, Ahmet/AGR-9682-2022; Keskin,
   Gökhan/CAJ-0357-2022; Cay, Serkan/JVP-0508-2024
OI Demir, Bulent/0000-0003-1767-408X
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NR 28
TC 14
Z9 14
U1 0
U2 3
PU VIA MEDICA
PI GDANSK
PA UL SWIETOKRZYSKA 73, 80-180 GDANSK, POLAND
SN 0022-9032
EI 1897-4279
J9 KARDIOL POL
JI Kardiol. Pol.
PD JAN
PY 2012
VL 70
IS 1
BP 31
EP 37
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 904BQ
UT WOS:000301169000010
PM 22267422
DA 2025-06-11
ER

PT J
AU Bouglé, D
   Brouard, J
AF Bougle, Dominique
   Brouard, Jacques
TI Iron in Child Obesity. Relationships with Inflammation and Metabolic
   Risk Factors
SO NUTRIENTS
LA English
DT Article
DE iron; obesity; children; inflammation; metabolic syndrome; non alcoholic
   fatty liver disease (NAFLD)
ID C-REACTIVE PROTEIN; INSULIN-RESISTANCE SYNDROME; SERUM FERRITIN; OBESE
   CHILDREN; MAJOR DETERMINANTS; OXIDATIVE STRESS; LIVER-DISEASE; FATTY
   LIVER; DEFICIENCY; WOMEN
AB Iron (Fe) sequestration is described in overweight and in its associated metabolic complications, i.e., metabolic syndrome (MetS) and non-alcoholic liver fatty disease (NAFLD); however, the interactions between Fe, obesity and inflammation make it difficult to recognize the specific role of each of them in the risk of obesity-induced metabolic diseases. Even the usual surrogate marker of Fe stores, ferritin, is influenced by inflammation; therefore, in obese subjects inflammation parameters must be measured together with those of Fe metabolism. This cross-sectional study in obese youth (502 patients; 57% girls): 11.4 +/- 3.0 years old (x +/- SD); BMI z score 5.5 +/- 2.3), multivariate regression analysis showed associations between Fe storage assessed by serum ferritin with risk factors for MetS and NAFLD, assessed by transaminase levels, which were independent of overweight and the acute phase protein fibrinogen. Further studies incorporating the measurement of complementary parameters of Fe metabolism could improve the comprehension of mechanisms involved.
C1 [Bougle, Dominique; Brouard, Jacques] CHU Caen, Dept Pediat, F-14033 Caen, France.
C3 CHU de Caen NORMANDIE; Universite de Caen Normandie
RP Bouglé, D (corresponding author), CHU Caen, Dept Pediat, F-14033 Caen, France.
EM dbougle@wanadoo.fr; brouard-jacques@chu-caen.fr
RI Brouard, Jacques/AAH-3387-2020
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NR 46
TC 21
Z9 22
U1 0
U2 12
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JUN
PY 2013
VL 5
IS 6
BP 2222
EP 2230
DI 10.3390/nu5062222
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 169HS
UT WOS:000320771400023
PM 23783556
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Frühbeck, G
   Catalán, V
   Rodríguez, A
   Ramírez, B
   Becerril, S
   Salvador, J
   Portincasa, P
   Colina, I
   Gómez-Ambrosi, J
AF Fruhbeck, Gema
   Catalan, Victoria
   Rodriguez, Amaia
   Ramirez, Beatriz
   Becerril, Sara
   Salvador, Javier
   Portincasa, Piero
   Colina, Inmaculada
   Gomez-Ambrosi, Javier
TI Involvement of the leptin-adiponectin axis in inflammation and oxidative
   stress in the metabolic syndrome
SO SCIENTIFIC REPORTS
LA English
DT Article
ID SERUM AMYLOID-A; CARDIOMETABOLIC RISK-FACTORS; C-REACTIVE PROTEIN;
   INSULIN-RESISTANCE; ADIPOSE-TISSUE; INDEPENDENT PREDICTORS; KEY PLAYER;
   OBESITY; OSTEOPONTIN; PLASMA
AB The aim of the present work was to study whether the leptin-adiponectin axis may have a pathophysiological role in the increased systemic inflammation and oxidative stress observed in patients with the metabolic syndrome (MS). Leptin, adiponectin, and markers of inflammation and oxidative stress were measured in a sample of 140 Caucasian subjects (74 males/66 females), aged 28-82 years, 60 with and 80 without the MS. Total concentrations of adiponectin as well as its multimeric forms HMW, MMW and LMW were significantly lower in individuals with the MS. The ratio adiponectin/leptin, a marker of dysfunctional adipose tissue, was dramatically decreased in the MS group. Systemic oxidative stress, as evidenced by levels of thiobarbituric acid reactive substances (TBARS), as well as markers of inflammation such as serum amyloid A (SAA), C-reactive protein (CRP) and osteopontin were significantly increased in subjects with the MS. Total adiponectin concentrations were negatively correlated with levels of TBARS and CRP levels. Furthermore, the ratio adiponectin/leptin was negatively correlated with SAA concentrations as well as with CRP levels. We concluded that a dysfunctional adipose tissue as suggested by a low adiponectin/leptin ratio may contribute to the increased oxidative stress and inflammation, hallmarks of the MS.
C1 [Fruhbeck, Gema; Catalan, Victoria; Rodriguez, Amaia; Ramirez, Beatriz; Becerril, Sara; Gomez-Ambrosi, Javier] Clin Univ Navarra, Metab Res Lab, Pamplona, Spain.
   [Fruhbeck, Gema; Catalan, Victoria; Rodriguez, Amaia; Ramirez, Beatriz; Becerril, Sara; Salvador, Javier; Gomez-Ambrosi, Javier] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr CIBEROBN, Pamplona, Spain.
   [Fruhbeck, Gema; Catalan, Victoria; Rodriguez, Amaia; Ramirez, Beatriz; Becerril, Sara; Colina, Inmaculada; Gomez-Ambrosi, Javier] Inst Invest Sanitaria Navarra IdiSNA, Obes & Adipobiol Grp, Pamplona, Spain.
   [Fruhbeck, Gema; Salvador, Javier] Clin Univ Navarra, Dept Endocrinol & Nutr, Pamplona, Spain.
   [Portincasa, Piero] Univ Bari, Med Sch, Policlin Hosp, Dept Biomed Sci & Human Oncol,Clin Med A Murri, Bari, Italy.
   [Colina, Inmaculada] Clin Univ Navarra, Dept Internal Med, Pamplona, Spain.
C3 University of Navarra; Instituto de Salud Carlos III; CIBER - Centro de
   Investigacion Biomedica en Red; CIBEROBN; University of Navarra;
   Universita degli Studi di Bari Aldo Moro; University of Navarra
RP Gómez-Ambrosi, J (corresponding author), Clin Univ Navarra, Metab Res Lab, Pamplona, Spain.; Gómez-Ambrosi, J (corresponding author), Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr CIBEROBN, Pamplona, Spain.; Gómez-Ambrosi, J (corresponding author), Inst Invest Sanitaria Navarra IdiSNA, Obes & Adipobiol Grp, Pamplona, Spain.
RI portincasa, piero/J-7245-2018; Rodríguez, Amaia/D-3044-2019;
   Gómez-Ambrosi, Javier/D-2984-2017; Ramírez, Beatriz/I-1922-2017;
   Catalan, Victoria/H-3566-2017
OI Catalan, Victoria/0000-0002-7513-7509
FU FIS [PI13/00460, PI14/00950, PI16/01217]; Spanish Instituto de Salud
   Carlos III-Subdireccion General de Evaluacion y Fomento de la
   investigacion-FEDER; Centro de Investigacion Biomedica en Red
   Fisiopatologia de la Obesidad y Nutricion, CIBEROBN, ISCIII, Spain
FX The authors thank all the individuals who participated in this study.
   This work was supported by the project grants FIS PI13/00460, PI14/00950
   and PI16/01217, integrated in the Plan Estatal I + D + I 2013-16 from
   the Spanish Instituto de Salud Carlos III-Subdireccion General de
   Evaluacion y Fomento de la investigacion-FEDER and by Centro de
   Investigacion Biomedica en Red Fisiopatologia de la Obesidad y
   Nutricion, CIBEROBN, ISCIII, Spain.
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NR 44
TC 146
Z9 152
U1 0
U2 12
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD JUL 26
PY 2017
VL 7
AR 6619
DI 10.1038/s41598-017-06997-0
PG 8
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA FB8CL
UT WOS:000406366400027
PM 28747790
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Brugnera, A
   Compare, A
   Omboni, S
   Greco, A
   Carrara, S
   Tasca, GA
   Poletti, B
   Parati, G
AF Brugnera, Agostino
   Compare, Angelo
   Omboni, Stefano
   Greco, Andrea
   Carrara, Silvia
   Tasca, Giorgio Angelo
   Poletti, Barbara
   Parati, Gianfranco
TI Psychological Covariates of Blood Pressure Among Patients With
   Hypertension and Metabolic Syndrome
SO HEALTH PSYCHOLOGY
LA English
DT Article
DE blood pressure; depression; hypertension; quality of life; well-being
ID QUALITY-OF-LIFE; EUROPEAN-SOCIETY; ARTERIAL-HYPERTENSION; PSYCHOSOCIAL
   STRESS; PRACTICE GUIDELINES; HEALTH INTERVIEW; RISK; DEPRESSION;
   METAANALYSIS; ASSOCIATION
AB Objective: Previous research provides support for the role of psychosocial variables in the progression of hypertension. However, few studies have rigorously tested the longitudinal interplay between blood pressure and depressive symptoms, quality of life, and well-being. Fewer still disaggregate the effects of changes of these psychological variables within patients over time from the effects of differences between patients on essential hypertension. Method: A total of 185 patients with hypertension and metabolic syndrome (130 males, 70.3%; mean age 54 +/- 10.93 years) volunteered for this multicentre study. We analyzed the longitudinal associations between office or daytime ambulatory blood pressure with depressive symptoms, well-being, and quality of life, measured at the same three time points (baseline and 36- and 48-week follow-up), through multilevel models and controlling for several sociodemographic and clinical factors. Results: Within-person increases in depressive symptoms were significant, positive time-varying covariates of both office and daytime blood pressure, even after controlling for several potential confounders (e.g., age, sex, changes over time in risk factors for metabolic syndrome). Within-person increases in well-being and mental health components of quality of life had similar negative associations with the level of blood pressure over time. Between-person differences in these variables tended not to predict blood pressure. Conclusions: Our findings provide a deeper insight on the relationship between variability of psychological variables within individuals and their levels of blood pressure. The findings support the need for health services to implement evidence-based psychological interventions that can foster a better management of the hypertensive disease.
C1 [Brugnera, Agostino; Compare, Angelo; Greco, Andrea; Carrara, Silvia] Univ Bergamo, Dept Human & Social Sci, Ple S Agostino 2, I-24129 Bergamo, Italy.
   [Omboni, Stefano] Sechenov First Moscow State Med Univ, Dept Cardiol, Moscow, Russia.
   [Tasca, Giorgio Angelo] Univ Ottawa, Sch Psychol, Ottawa, ON, Canada.
   [Poletti, Barbara] IRCCS, Dept Neurol, Ist Auxol Italiano, Milan, Italy.
   [Poletti, Barbara] IRCCS, Lab Neurosci, Ist Auxol Italiano, Milan, Italy.
   [Parati, Gianfranco] Univ Milano Bicocca, Sch Med & Surg, Milan, Italy.
   [Parati, Gianfranco] IRCCS, Dept Cardiovasc Neural & Metab Sci, San Luca Hosp, Ist Auxol Italiano, Milan, Italy.
C3 University of Bergamo; Sechenov First Moscow State Medical University;
   University of Ottawa; IRCCS Istituto Auxologico Italiano; IRCCS Istituto
   Auxologico Italiano; University of Milano-Bicocca; IRCCS Istituto
   Auxologico Italiano
RP Brugnera, A (corresponding author), Univ Bergamo, Dept Human & Social Sci, Ple S Agostino 2, I-24129 Bergamo, Italy.
EM agostino.brugnera@unibg.it
RI Carrara, Silvia/AAC-5298-2022; Tasca, Giorgio/AAG-1867-2019; Poletti,
   Barbara/W-6917-2019; Greco, Andrea/I-7266-2016; Poletti,
   Barbara/K-9332-2016; Compare, Prof. Angelo/H-3519-2014; Omboni,
   Stefano/D-1327-2015; Parati, Gianfranco/K-7151-2016
OI Greco, Andrea/0000-0002-8086-2801; Brugnera,
   Agostino/0000-0002-4066-4552; Poletti, Barbara/0000-0003-4398-2051;
   Compare, Prof. Angelo/0000-0002-3336-7920; Omboni,
   Stefano/0000-0002-7124-2096; Parati, Gianfranco/0000-0001-9402-7439
FU Bracco S.p.A.
FX This work was financially supported by Bracco S.p.A. through an
   unconditional and unrestricted grant.
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NR 54
TC 5
Z9 5
U1 0
U2 8
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 0278-6133
EI 1930-7810
J9 HEALTH PSYCHOL
JI Health Psychol.
PD DEC
PY 2022
VL 41
IS 12
BP 946
EP 954
DI 10.1037/hea0001205
EA JUL 2022
PG 9
WC Psychology, Clinical; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology
GA 6G0ZB
UT WOS:000827799500001
PM 35862126
DA 2025-06-11
ER

PT J
AU Nyboe, L
   Vestergaard, CH
   Lund, H
   Moller, MK
   Videbech, P
AF Nyboe, L.
   Vestergaard, C. H.
   Lund, H.
   Moller, M. K.
   Videbech, P.
TI Metabolic syndrome in first-time hospitalized patients with depression:
   a 1-year follow-up study
SO ACTA PSYCHIATRICA SCANDINAVICA
LA English
DT Article
DE depression; metabolic syndrome; aerobic fitness; antipsychotics
ID MAJOR DEPRESSION; PHYSICAL-ACTIVITY; CARDIORESPIRATORY FITNESS; EXCESS
   MORTALITY; MOOD DISORDERS; LIFE-STYLE; METAANALYSIS; ANXIETY; RISK;
   SCHIZOPHRENIA
AB ObjectiveStudies on metabolic syndrome (MetS) in younger patients with depression are few. We examined the prevalence and progression of MetS in first-time hospitalized patients with depression during 1year of follow-up. Furthermore, we explored putative risk factors of MetS.
   MethodWe evaluated MetS and its components in first-time hospitalized patients with depression (N=52) and healthy controls (N=50) (18-45years). Physical activity, aerobic fitness, sleeping disturbances, smoking and dietary habits, and psychopharmacological treatment were recorded at baseline for all participants and after 1year for the patients.
   ResultsPatients had significantly higher waist circumference (WC) and lower high-density lipoproteins compared with healthy controls (P<0.05). Patients had higher prevalence of MetS, but this was not significant when adjusted for age. Patients had significant increase in WC and triglycerides and a non-significant increase in the prevalence of MetS. Antipsychotic medication (OR 10.5, 95% CI 1.18-94.14) and low aerobic fitness (OR 0.79, 95% CI 0.68-0.93) were significantly correlated with MetS (P<0.05).
   ConclusionMetabolic syndrome is highly prevalent in younger, severely depressed patients and the incidence increases during 1year of follow-up. Low aerobic fitness and use of atypical antipsychotics are strongly correlated with MetS.
C1 [Nyboe, L.; Vestergaard, C. H.; Videbech, P.] Aarhus Univ Hosp Risskov, Res Unit, Dept Affect Disorders Q, Skovagervej 2, DK-8240 Risskov, Denmark.
   [Lund, H.] Univ Southern Denmark, Dept Sports Sci & Clin Biomech, Res Unit Musculoskeletal Funct & Physiotherapy, SEARCH Res Grp Synth Evidence & Res, Odense, Denmark.
   [Lund, H.] Bergen Univ Coll, Ctr Evidence Based Practice, Bergen, Norway.
   [Moller, M. K.] Horsens Reg Hosp, Dept Med, Horsens, Denmark.
C3 Aarhus University; University of Southern Denmark; Western Norway
   University of Applied Sciences
RP Nyboe, L (corresponding author), Aarhus Univ Hosp Risskov, Res Unit, Dept Affect Disorders Q, Skovagervej 2, DK-8240 Risskov, Denmark.
EM lene.nyboe@ps.rm.dk
RI Lund, Hans/HWT-2338-2023; Videbech, Poul/B-1924-2008; Lund,
   Hans/E-4075-2013
OI Videbech, Poul/0000-0003-0127-4348; Nyboe, Lene/0000-0001-7131-3010;
   Lund, Hans/0000-0001-6847-8324; Vestergaard, Claus
   Hostrup/0000-0003-2916-1548
FU Psychiatric Research Fund, Central Region of Denmark; Lundbeck Fund;
   Danish Physical Therapy Federation
FX The study was funded by The Psychiatric Research Fund, Central Region of
   Denmark, The Lundbeck Fund, and the Danish Physical Therapy Federation.
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NR 49
TC 8
Z9 10
U1 0
U2 10
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0001-690X
EI 1600-0447
J9 ACTA PSYCHIAT SCAND
JI Acta Psychiatr. Scand.
PD MAR
PY 2016
VL 133
IS 3
BP 241
EP 248
DI 10.1111/acps.12470
PG 8
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA DD7BF
UT WOS:000370078000009
PM 26251964
DA 2025-06-11
ER

PT J
AU Hoogervorst, MM
   van Meijel, B
   Krijnen-de Bruin, E
   Beekman, A
   Boonstra, N
   Adriaanse, M
AF Hoogervorst, Meike M.
   van Meijel, Berno
   Krijnen-de Bruin, Esther
   Beekman, Aartjan
   Boonstra, Nynke
   Adriaanse, Marcel
TI The nurse-led GILL eHealth intervention for improving physical health
   and lifestyle behaviours in clients with severe mental illness: design
   of a cluster-randomised controlled trial
SO BMC PSYCHIATRY
LA English
DT Article
DE Severe mental illness; Somatic screening; eHealth intervention;
   Lifestyle behaviours; RCT; Process evaluation; Metabolic syndrome
ID PSYCHOMETRIC PROPERTIES; METABOLIC SYNDROME; TRAINING NEEDS; PEOPLE;
   CARE; SCHIZOPHRENIA; QUESTIONNAIRE; PREVALENCE; DISORDERS; MORTALITY
AB BackgroundClients with severe mental illness (SMI) have overall poor physical health. SMI reduces life expectancy by 5-17 years, primarily due to physical comorbidity linked to cardiometabolic risks that are mainly driven by unhealthy lifestyle behaviours. To improve physical health in clients with SMI, key elements are systematic somatic screening and lifestyle promotion. The nurse-led GILL eHealth was developed for somatic screening and the implementation of lifestyle activities in clients with SMI. Aims of this study are to evaluate the effectiveness of the GILL eHealth intervention in clients with SMI compared to usual care, and to evaluate the implementation process, and the experiences of clients and healthcare providers with GILL eHealth.MethodsThe GILL study encompasses a cluster-randomised controlled trial in approximately 20 mental health care facilities in the Netherlands. The randomisation takes place at the team level, assigning clients to the eHealth intervention or the usual care group. The GILL eHealth intervention consists of two complementary modules for somatic screening and lifestyle promotion, resulting in personalised somatic treatment and lifestyle plans. Trained mental health nurses and nurse practitioners will implement the intervention within the multidisciplinary treatment context, and will guide and support the participants in promoting their physical health, including cardiometabolic risk management. Usual care includes treatment as currently delivered, with national guidelines as frame of reference. We aim to include 258 clients with SMI and a BMI of 27 or higher. Primary outcome is the metabolic syndrome severity score. Secondary outcomes are physical health measurements and participants' reports on physical activity, perceived lifestyle behaviours, quality of life, recovery, psychosocial functioning, and health-related self-efficacy. Measurements will be completed at baseline and at 6 and 12 months. A qualitative process evaluation will be conducted alongside, to evaluate the process of implementation and the experiences of clients and healthcare professionals with GILL eHealth.DiscussionThe GILL eHealth intervention is expected to be more effective than usual care in improving physical health and lifestyle behaviours among clients with SMI. It will also provide important information on implementation of GILL eHealth in mental health care. If proven effective, GILL eHealth offers a clinically useful tool to improve physical health and lifestyle behaviours.Trial registrationClinical trial registration NCT05533749, registration date: 8 September 2022.
C1 [Hoogervorst, Meike M.; van Meijel, Berno; Beekman, Aartjan; Adriaanse, Marcel] Amsterdam UMC, Dept Psychiat, Amsterdam, Netherlands.
   [Hoogervorst, Meike M.; van Meijel, Berno; Beekman, Aartjan] Amsterdam Publ Hlth Res Inst, Amsterdam, Netherlands.
   [van Meijel, Berno; Krijnen-de Bruin, Esther] Inholland Univ Appl Sci, Dept Hlth Sports & Welf, Amsterdam, Netherlands.
   [van Meijel, Berno] Parnassia Acad, Parnassia Psychiat Inst, The Hague, Netherlands.
   [Boonstra, Nynke] Univ Med Ctr Utrecht, UMC Utrecht Brain Ctr, Dept Psychiat, Utrecht, Netherlands.
   [Boonstra, Nynke] Univ Appl Sci, NHL Stenden, Leeuwarden, Netherlands.
   [Boonstra, Nynke] KieN VIP Mental Hlth Care Serv, Leeuwarden, Netherlands.
   [Adriaanse, Marcel] Vrije Univ Amsterdam, Dept Hlth Sci, Amsterdam, Netherlands.
C3 Vrije Universiteit Amsterdam; University of Amsterdam; Vrije
   Universiteit Amsterdam; Parnassia Psychiatric Institute; Utrecht
   University; Utrecht University Medical Center; NHL Stenden University of
   Applied Sciences; Vrije Universiteit Amsterdam
RP Hoogervorst, MM (corresponding author), Amsterdam UMC, Dept Psychiat, Amsterdam, Netherlands.
EM m.m.hoogervorst@amsterdamumc.nl
RI Beekman, Aartjan T./LUZ-6919-2024; Adriaanse, Marieke/AFQ-8371-2022
OI Adriaanse, Marcel/0000-0002-5085-6662; Boonstra,
   Nynke/0000-0003-3592-1953
FU Netherlands Organisation for Health Research and Development, ZonMw
   [10040022010002]; Amsterdam University Medical Centre
FX This study was supported by a grant from the Netherlands Organisation
   for Health Research and Development, ZonMw (grant no. 10040022010002).
   The funder had no role in the design or execution of the study, data
   collection, analysis and interpretation, decision to publish, or writing
   of the manuscript. The Amsterdam University Medical Centre is the
   sponsor of this study.
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NR 58
TC 0
Z9 0
U1 1
U2 4
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-244X
J9 BMC PSYCHIATRY
JI BMC Psychiatry
PD SEP 15
PY 2023
VL 23
IS 1
AR 672
DI 10.1186/s12888-023-05024-z
PG 10
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychiatry
GA R8JS2
UT WOS:001066770200004
PM 37715156
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Crichton, GE
   Elias, MF
   Robbins, MA
AF Crichton, Georgina E.
   Elias, Merrill F.
   Robbins, Michael A.
TI Association between depressive symptoms, use of antidepressant
   medication and the metabolic syndrome: the Maine-Syracuse Study
SO BMC PUBLIC HEALTH
LA English
DT Article
DE Depressed mood; Antidepressants; Metabolic syndrome
ID CARDIOVASCULAR-DISEASE; COGNITIVE FUNCTION; CES-D; ANXIETY; RISK;
   RELIABILITY; OBESITY; STRESS; SAMPLE; COMORBIDITY
AB Background: Both depression and the metabolic syndrome (MetS) are two major public health issues. The aim of this study was to examine associations between depressive symptoms, the use of antidepressant medications, and the prevalence of MetS.
   Methods: Cross-sectional analyses were undertaken on 970 participants from the Maine-Syracuse Study. Depressive symptoms were measured using two self-reported depression scales, the Center for Epidemiological Studies Depression Scale (CES-D), and the Zung self-rating depression scale. Antidepressant medication use was also self-reported. MetS was defined according to the recent harmonized criteria.
   Results: The risk of MetS were approximately 79 and 86 % higher for those in the highest quartile for the CES-D and the Zung (CES-D: OR = 1.79, p = 0.003; Zung: OR = 1.71, p = 0.006), compared to those in the lowest quartile. With adjustment for socio-demographic variables, lifestyle factors and C-reactive protein (CRP), risk was attenuated, but remained statistically significant for the CES-D. In those who reported using antidepressant medication, the odds of having MetS were over 2-fold higher (OR = 2.22, p < 0.001, fully adjusted model), compared to those who did not use antidepressants. Both measures of depressed mood were also associated with low high density-lipoprotein (HDL) cholesterol levels. Antidepressant use was associated with elevated fasting plasma glucose concentrations, hypertension, and low HDL-cholesterol.
   Conclusion: Depressive symptoms and the use of antidepressant medications are associated with the prevalence of MetS, and with some of the individual components of the syndrome.
C1 [Crichton, Georgina E.] Univ S Australia, Sansom Inst Hlth Res, ARENA, GPO Box 2471, Adelaide, SA 5001, Australia.
   [Elias, Merrill F.; Robbins, Michael A.] Univ Maine, Dept Psychol, Orono, ME 04469 USA.
   [Elias, Merrill F.; Robbins, Michael A.] Univ Maine, Grad Sch Biomed Sci & Engn, Orono, ME USA.
C3 University of South Australia; University of Maine System; University of
   Maine Orono; University of Maine System; University of Maine Orono
RP Crichton, GE (corresponding author), Univ S Australia, Sansom Inst Hlth Res, ARENA, GPO Box 2471, Adelaide, SA 5001, Australia.
EM georgina.crichton@unisa.edu.au
FU National Heart, Lung, and Blood Institute [R01HL67358, R01HL81290];
   National Institute on Aging [R01AG03055]; Sidney Sax Research Fellowship
   (National Health and Medical Research Council, Australia) [APP1054567]
FX The authors greatly appreciate the study participants and those who
   assisted with data collection. This study was supported in part by
   National Heart, Lung, and Blood Institute (grant numbers R01HL67358,
   R01HL81290); by the National Institute on Aging (grant R01AG03055). GEC
   was supported by a Sidney Sax Research Fellowship (National Health and
   Medical Research Council, Australia, grant number APP1054567).
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NR 50
TC 28
Z9 30
U1 0
U2 6
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2458
J9 BMC PUBLIC HEALTH
JI BMC Public Health
PD JUN 10
PY 2016
VL 16
AR 502
DI 10.1186/s12889-016-3170-2
PG 9
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA DO3WN
UT WOS:000377713300012
PM 27287001
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Li, JB
   Wang, X
   Zhang, JX
   Gu, P
   Zhang, X
   Chen, CX
   Guo, R
   Wu, M
AF Li, J-B
   Wang, X.
   Zhang, J-X
   Gu, P.
   Zhang, X.
   Chen, C-X
   Guo, R.
   Wu, M.
TI Metabolic Syndrome: Prevalence and Risk Factors in Southern China
SO JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
LA English
DT Article
DE METABOLIC SYNDROME; PREVALENCE; RISK FACTORS; SOUTHERN CHINESE
   POPULATION
ID CORONARY-HEART-DISEASE; INSULIN-RESISTANCE; CARDIOVASCULAR-DISEASE;
   SLEEP
AB This was a cross-sectional study to investigate the epidemiology of metabolic syndrome and the distribution of interrelated metabolic abnormalities in different population groups in Guangdong, southern China. Individuals were recruited according to the percentage of different occupational populations in southern China. The study cohort included 1206 subjects, and the prevalence and distribution of the components of metabolic syndrome were assessed using the National Cholesterol Education Program Adult Treatment Panel III 2005 criteria. The unadjusted rate of metabolic syndrome was 26.7%, and the prevalences of hypertension and diabetes were 38.0% and 4.3% respectively. Hypertension, diabetes, metabolic syndrome, abdominal obesity, elevated blood glucose and elevated blood pressure decreased significantly with increasing levels of life stress and anxiety. The prevalence of hypertension and metabolic syndrome in southern China is very high, and early identification and treatment of at-risk individuals may help target intervention to improve future cardiovascular health.
C1 [Li, J-B; Wang, X.; Zhang, J-X; Zhang, X.] Sun Yat Sen Univ, Sch Publ Hlth, Dept Med Stat & Epidemiol, Guangzhou 510080, Guangdong, Peoples R China.
   [Gu, P.; Chen, C-X; Guo, R.; Wu, M.] Guangdong Acad Med Sci, Guangdong Gen Hosp, Phys Examinat Ctr, Guangzhou, Guangdong, Peoples R China.
C3 Sun Yat Sen University; Southern Medical University - China; Guangdong
   Academy of Medical Sciences & Guangdong General Hospital
RP Zhang, JX (corresponding author), Sun Yat Sen Univ, Sch Publ Hlth, Dept Med Stat & Epidemiol, 74 Zhongshan Rd 2, Guangzhou 510080, Guangdong, Peoples R China.
EM zhjinx@mail.sysu.edu.cn
RI Li, Ji-Bin/J-6381-2018; cx, chen/AGP-3922-2022
FU Guangdong Science and Technology Planned Project [2006B36008008];
   Guangdong Provincial People's Hospital
FX This study was supported by the research fund from the Guangdong Science
   and Technology Planned Project (serial number 2006B36008008). We express
   our gratitude to all the participants, physicians and nurses in
   Guangdong Provincial People's Hospital, whose support helped with the
   completion of the investigation.
CR [Anonymous], ACTA CARDIOL SIN
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NR 20
TC 32
Z9 36
U1 1
U2 10
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0300-0605
EI 1473-2300
J9 J INT MED RES
JI J. Int. Med. Res.
PD MAY-JUN
PY 2010
VL 38
IS 3
BP 1142
EP 1148
DI 10.1177/147323001003800343
PG 7
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA 635SY
UT WOS:000280677800044
PM 20819453
DA 2025-06-11
ER

PT J
AU Koponen, H
   Jokelainen, J
   Keinänen-Kiukaanniemi, S
   Kumpusalo, E
   Vanhala, M
AF Koponen, Hannu
   Jokelainen, Jari
   Keinanen-Kiukaanniemi, Sirkka
   Kumpusalo, Esko
   Vanhala, Mauno
TI Metabolic syndrome predisposes to depressive symptoms:: A
   population-based 7-year follow-up study
SO JOURNAL OF CLINICAL PSYCHIATRY
LA English
DT Article
ID CARDIOVASCULAR-DISEASE; INSULIN-RESISTANCE; ASSOCIATION; OBESITY;
   DEFINITION; INVENTORY; AMERICAN; HEALTH; ADULTS
AB Objective: Previous cross-sectional studies have suggested that patients with depression have a high risk for metabolic syndrome. As there is a paucity of data concerning the temporal relationship of depression and metabolic syndrome, we decided to evaluate the risk for developing depressive symptoms in patients with metabolic syndrome in a population-based follow-up study.
   Method: The prevalence of depressive symptoms and metabolic syndrome at baseline in 1998 and at 7-year follow-up in 2004/2005 was studied in a large, middle-aged, population-based sample collected from Central Finland. Depressive symptoms were measured with the Beck Depression Inventory, with a cutoff score of 10 points. Metabolic syndrome was assessed using the modified National Cholesterol Education Program Adult Treatment Panel III criteria.
   Results: Nondepressed women and men with metabolic syndrome at baseline were twice as likely to have depressive symptoms at follow-up (OR = 2.2, 95% CI = 1.1 to 4.5 for women; OR = 2.2, 95% CI = 0.8 to 5.9 for men) as compared with the nondepressed cohort members without metabolic syndrome at baseline.
   Conclusions: The higher rate of depressive symptoms in the subgroup with metabolic syndrome suggests that the metabolic syndrome may be an important predisposing factor for the development of depression. Effective prevention and treatment of metabolic syndrome could also be important for the prevention of depression.
C1 [Koponen, Hannu] Kuopio Univ Hosp, Dept Psychiat, FIN-70211 Kuopio, Finland.
   [Koponen, Hannu] Univ Kuopio, Dept Psychiat, FIN-70211 Kuopio, Finland.
   [Kumpusalo, Esko] Univ Kuopio, Dept Family Med, Sch Publ Hlth & Clin Nutr, FIN-70211 Kuopio, Finland.
   [Kumpusalo, Esko] Kuopio Univ Hosp, Unit Family Practice, SF-70210 Kuopio, Finland.
   [Jokelainen, Jari; Keinanen-Kiukaanniemi, Sirkka] Oulu Univ, Unit Gen Practice, Dept Publ Hlth Sci, Oulu Univ Hosp, Oulu, Finland.
   [Keinanen-Kiukaanniemi, Sirkka] Oulu Hlth Ctr, Oulu, Finland.
   [Vanhala, Mauno] Cent Finland Hosp Dist, Laukaa Hlth Ctr, Jyvaskyla, Finland.
C3 Kuopio University Hospital; University of Eastern Finland; University of
   Eastern Finland; Kuopio University Hospital; University of Eastern
   Finland; University of Eastern Finland Hospital; University of Oulu;
   Central Finland Central Hospital
RP Koponen, H (corresponding author), Kuopio Univ Hosp, Dept Psychiat, POB 1777, FIN-70211 Kuopio, Finland.
EM hannujuhani.koponen@uku.fi
OI Jokelainen, Jari/0000-0003-4629-0560
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NR 28
TC 139
Z9 151
U1 0
U2 9
PU PHYSICIANS POSTGRADUATE PRESS
PI MEMPHIS
PA P O BOX 752870, MEMPHIS, TN 38175-2870 USA
SN 0160-6689
EI 1555-2101
J9 J CLIN PSYCHIAT
JI J. Clin. Psychiatry
PD FEB
PY 2008
VL 69
IS 2
BP 178
EP 182
DI 10.4088/JCP.v69n0202
PG 5
WC Psychology, Clinical; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA 267JW
UT WOS:000253506300002
PM 18232723
DA 2025-06-11
ER

PT J
AU Kang, DR
   Ha, Y
   Hwang, WJ
AF Kang, Dae Ryong
   Ha, Yeongmi
   Hwang, Won Ju
TI Prevalence and Associated Risk Factor of the Metabolic Syndrome in the
   Korean Workforce
SO INDUSTRIAL HEALTH
LA English
DT Article
DE Occupational epidemiology; Work environments; Cardiovascular disorders;
   Psychosocial stress; Metabolic syndrome
ID CHOLESTEROL EDUCATION-PROGRAM; CARDIOVASCULAR-DISEASE RISK; MALE
   WORKERS; ADULTS; STRESS; DEPRESSION; OBESITY; COHORT; WOMEN
AB The purposes of this study were to estimate the prevalence of metabolic syndrome and to investigate the risk factors associated with metabolic syndrome in Korean workers. This is a secondary data analysis study using the data set from the Korean National Health and Nutrition Examination Survey IV. A total of 1,545 workers over 20 yr of age were included in this analysis. The prevalence of metabolic syndrome was determined using the modified National Cholesterol Education Program Adult Treatment Panel III criteria. Waist circumference was based on the study of obesity guidelines. The overall prevalence of metabolic syndrome among Korean workers was 21.0% (28.5% men, 11.8% women). In a multiple logistic regression analysis, male workers with high job control and heavy alcohol consumption were significantly associated with metabolic syndrome. For women, low job control and current smoking increased the risk of metabolic syndrome. The risk of developing metabolic syndrome is strongly associated with level of job control in both male and female workers. These findings suggest that behavioral lifestyle modifications, including smoking cessation, moderating alcohol consumption, and controlling work-related factors and job control in the workplace should be considered for the prevention and management of metabolic syndrome in Korean workers.
C1 [Kang, Dae Ryong] Yonsei Univ, Coll Med, Biostat Collaborat Unit, Seoul 120749, South Korea.
   [Ha, Yeongmi] Gyeongsang Natl Univ, Sch Nursing, Chinju, South Korea.
   [Ha, Yeongmi] Gyeongsang Natl Univ, Inst Hlth Sci, Chinju, South Korea.
   [Hwang, Won Ju] Kyung Hee Univ, East West Nursing Res Inst, Coll Nursing Sci, Seoul, South Korea.
C3 Yonsei University; Yonsei University Health System; Gyeongsang National
   University; Gyeongsang National University; Kyung Hee University
RP Hwang, WJ (corresponding author), Kyung Hee Univ, East West Nursing Res Inst, Coll Nursing Sci, Seoul, South Korea.
EM hwangwj@khu.ac.kr
RI Ha, Yeongmi/KXR-8828-2024
OI Hwang, Won Ju/0000-0002-0498-6183
CR Choi ES, 2009, J KOREAN ACAD NURS, V39, P549, DOI 10.4040/jkan.2009.39.4.549
   Choi KM, 2007, METABOLISM, V56, P552, DOI 10.1016/j.metabol.2006.12.003
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Demiral Y, 2006, J OCCUP HEALTH, V48, P332, DOI 10.1539/joh.48.332
   Ferrari CKB, 2008, J EXERC SCI FIT, V6, P87
   Galassi A, 2006, AM J MED, V119, P812, DOI 10.1016/j.amjmed.2006.02.031
   Godefroi R, 2005, CARDIOLOGY, V103, P131, DOI 10.1159/000083439
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   Grundy SM, 2005, CIRCULATION, V112, P2735, DOI 10.1161/CIRCULATIONAHA.105.169404
   Hu DS, 2008, DIABETES RES CLIN PR, V81, P250, DOI 10.1016/j.diabres.2008.04.008
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   Hwang WJ, 2012, EUR J CARDIOVASC NUR, V11, P114, DOI 10.1177/1474515111430890
   Kang MG, 2005, PREV MED, V40, P583, DOI 10.1016/j.ypmed.2004.07.018
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   KimYangHyun, 2009, Annals of Occupational and Environmental Medicine, V21, P209
   KNSO, 2007, KOR STAND IND CLASS, V2010
   Korea Centers for Disease Control and Prevention, 2008, 4 KOR NAT HLTH NUTR
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   Lee KJ, 2004, SEX ROLES, V51, P469, DOI 10.1023/B:SERS.0000049235.60839.ef
   Lee SY, 2007, DIABETES RES CLIN PR, V75, P72, DOI 10.1016/j.diabres.2006.04.013
   Lin YC, 2009, WORLD J GASTROENTERO, V15, P5654, DOI 10.3748/wjg.15.5654
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   Myong Jun Pyo, 2009, J Prev Med Public Health, V42, P331, DOI 10.3961/jpmph.2009.42.5.331
   Park HS, 2004, INT J EPIDEMIOL, V33, P328, DOI 10.1093/ije/dyh032
   Ryu S, 2007, ANN EPIDEMIOL, V17, P245, DOI 10.1016/j.annepidem.2006.10.001
   Schultz AB, 2009, METAB SYNDR RELAT D, V7, P459, DOI 10.1089/met.2009.0008
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   Weitzman ER, 2003, HEALTH PLACE, V9, P1, DOI 10.1016/S1353-8292(02)00014-X
   WHO, 2004, APPR BOD MASS IND AS, V2009
NR 30
TC 13
Z9 13
U1 0
U2 4
PU NATL INST OCCUPATIONAL SAFETY & HEALTH, JAPAN
PI KAWASAKI KANAGAWA
PA 21-1 NAGAO 6-CHOME TAMA-KU, KAWASAKI KANAGAWA, 214, JAPAN
SN 0019-8366
EI 1880-8026
J9 IND HEALTH
JI Ind. Health
PD MAY
PY 2013
VL 51
IS 3
BP 256
EP 265
PG 10
WC Environmental Sciences; Public, Environmental & Occupational Health;
   Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health; Toxicology
GA 155YO
UT WOS:000319786800003
PM 23385434
OA Bronze
DA 2025-06-11
ER

PT J
AU Bosman, RC
   van Balkom, AJLM
   Rhebergen, D
   van Hemert, AM
   Schoevers, RA
   Penninx, BWJH
   Batelaan, NM
AF Bosman, R. C.
   van Balkom, A. J. L. M.
   Rhebergen, D.
   van Hemert, A. M.
   Schoevers, R. A.
   Penninx, B. W. J. H.
   Batelaan, N. M.
TI Predicting the course of anxiety disorders: The role of biological
   parameters
SO PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
LA English
DT Article
DE Anxiety disorders; Course trajectory; Metabolic syndrome; HPA-axis;
   Inflammation markers; BDNF
ID COURSE TRAJECTORIES; PANIC DISORDER; SOCIAL PHOBIA; 2-YEAR COURSE;
   DEPRESSION; ASSOCIATIONS; CORTISOL; DETERMINANTS; NETHERLANDS;
   COMORBIDITY
AB Objective Clinical characteristics appear limited in their ability to predict course of anxiety disorders, therefore we explored the predictive value of biological parameters on course of anxiety disorders.
   Methods 907 persons with an anxiety (panic, social phobia, generalised anxiety) disorder with a baseline and two-year follow-up measure were selected from the Netherlands Study of Depression and Anxiety (NESDA). Previously, three course trajectories were distinguished which vary in terms of symptom severity and chronicity. Baseline clinical parameters like anxiety severity, anxiety duration, and disability were limited in their ability to predict the two-year course. This study explored whether metabolic syndrome, hypothalamic-pituitary-adrenal-axis functioning, inflammation markers, and neuroplasticity were indicators of two-year course and whether these parameters improved the model containing the most predictive clinical parameters only.
   Results Baseline diastolic blood pressure of persons with chronic moderate symptoms was significantly higher than of persons with non-chronic mild symptoms (odds ratio [OR] = 1.18, 95% confidence interval [CI95%] 1.01 to 1.38). Baseline high-density lipid cholesterol of persons with severe chronic symptoms was significantly lower than of persons with non-chronic mild symptoms (OR = 0.77, CI95% 0.62 to 0.96). The predictive ability of both parameters was however low with concordance statistics of 0.55 and 0.57 respectively. Addition of biological parameters did not improve the predictive ability of the model containing the clinical parameters.
   Conclusions In addition to clinical characteristics, biological parameters did not improve the predictive ability of the model for course trajectory of anxiety disorders. Prediction of course trajectory in anxiety disorders remains difficult and warrants further research.
C1 [Bosman, R. C.; van Balkom, A. J. L. M.; Rhebergen, D.; Penninx, B. W. J. H.; Batelaan, N. M.] Vrije Univ, Amsterdam Publ Hlth Res Inst, Amsterdam UMC, Psychiat, Amsterdam, Netherlands.
   [Bosman, R. C.; van Balkom, A. J. L. M.; Rhebergen, D.; Batelaan, N. M.] GGZ InGeest Specialized Mental Hlth Care, Amsterdam, Netherlands.
   [van Hemert, A. M.] Leiden Univ, Dept Psychiat, Med Ctr, Leiden, Netherlands.
   [Schoevers, R. A.] Univ Groningen, Univ Med Ctr Groningen, Res Sch Behav & Cognit Neurosci BCN, Dept Psychiat, Groningen, Netherlands.
C3 Vrije Universiteit Amsterdam; University of Amsterdam; Leiden
   University; Leiden University Medical Center (LUMC); Leiden University -
   Excl LUMC; University of Groningen
RP Bosman, RC (corresponding author), Vrije Univ, Amsterdam UMC, Dept Psychiat, Oldenaller 1, NL-1081 HJ Amsterdam, Netherlands.
EM r.bosman@ggzingeest.nl
RI Bosman, R.C./K-6519-2019; Penninx, Brenda WJH/S-7627-2017
OI Schoevers, Robert A/0000-0003-0760-9866; Bosman, Renske
   C./0000-0002-3143-9345; Batelaan, Neeltje/0000-0001-6444-3781; Penninx,
   Brenda WJH/0000-0001-7779-9672
FU Netherlands Organisation for Health Research and Development (ZonMw)
   [10-0001002]; VU University Medical Center; GGZ in Geest; Leiden
   University Medical Center; Leiden University; GGZ Rivierduinen;
   University Medical Center Groningen; University of Groningen; Lentis;
   GGZ Friesland; GGZ Drenthe; Rob Giel Onderzoekscentrum; VICI grant (NWO)
   [g1811602]; Neuroscience Campus Amsterdam
FX The infrastructure for the NESDA study (www.nesda.nl) is funded through
   the Geestkracht program of the Netherlands Organisation for Health
   Research and Development (ZonMw, grant number 10-0001002) and financial
   contributions by participating universities and mental health care
   organizations (VU University Medical Center, GGZ in Geest, Leiden
   University Medical Center, Leiden University, GGZ Rivierduinen,
   University Medical Center Groningen, University of Groningen, Lentis,
   GGZ Friesland, GGZ Drenthe, Rob Giel Onderzoekscentrum). BP was
   supported through a VICI grant (NWO grant g1811602). Assaying of
   inflammatory markers was supported by the Neuroscience Campus Amsterdam.
   The funding source had no involvement in the study design, in the
   collection, analysis, and interpretation of data, in the writing of the
   report, and in the decision to submit the article for publication.
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NR 39
TC 4
Z9 4
U1 0
U2 12
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0278-5846
EI 1878-4216
J9 PROG NEURO-PSYCHOPH
JI Prog. Neuro-Psychopharmacol. Biol. Psychiatry
PD JUL 13
PY 2020
VL 101
AR 109924
DI 10.1016/j.pnpbp.2020.109924
PG 15
WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA LZ0GH
UT WOS:000540909600015
PM 32179152
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Park, SJ
   Roh, S
   Hwang, J
   Kim, HA
   Kim, S
   Lee, TK
   Kang, SH
   Ha, YJ
   Jang, JW
   Park, S
AF Park, Se Jin
   Roh, Sungwon
   Hwang, Jaemin
   Kim, Hyoung Ah
   Kim, Sohye
   Lee, Tae Kyung
   Kang, Shi Hyun
   Ha, Yu Jeong
   Jang, Jung Won
   Park, Subin
TI Association between depression and metabolic syndrome in korean women:
   Results from the korean national health and nutrition examination survey
   (2007-2013)
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Depression; Metabolic syndrome; Triglyceride; Cardiovascular disease
ID CARDIOVASCULAR-DISEASE; RISK-FACTORS; MORTALITY; SYMPTOMS; CHOLESTEROL;
   MANAGEMENT; COMPONENTS; ANXIETY; EVENTS; ADULTS
AB Background: A considerable amount of research suggests that depression may be associated with cardiovascular disease (CVD) and the risk factors for the development of CVD such as metabolic syndrome (MetS). This study aimed to investigate the associations between depression, MetS, and combinations of the individual MetS components in Korean women.
   Methods: Cross-sectional data for 23,385 women who aged 19 years and older were obtained from the nationally representative Korean National Health and Nutrition Examination Survey (2007-2013). Associations between prior diagnosis of depression and MetS were estimated after adjusting for related factors using multivariable logistic regression analysis.
   Results: MetS was more prevalent in women with a prior diagnosis of depression than those without diagnosed depression (26.20% vs. 19.07%, p < .001). Depression was significantly associated with MetS (odds ratio, 1.20; 95% confidence interval, 1.01-1.43) after adjusting for age, education, monthly household income, smoking status, alcohol use, physical activity, and postmenopausal status. There was a higher prevalence of most MetS combinations among women with depression than women without depression. Specifically, significant differences between the two groups were found for MetS combinations including high triglycerides.
   Limitations: A cross-sectional study design and lack of a standardized objective measure for depression.
   Conclusions: Diagnosed depression is associated with MetS in Korean women. Specifically, women with diagnosed depression have significantly elevated levels of several combinations of MetS components including high triglycerides. Addressing these MetS combinations could help reduce CVD events and mortality among women with depression. (C) 2016 Elsevier B.V. All rights reserved.
C1 [Park, Se Jin; Ha, Yu Jeong; Jang, Jung Won; Park, Subin] Natl Ctr Mental Hlth, Mental Hlth Res Inst, Dept Res Planning, 127 Youngmasan Ro, Seoul 04933, South Korea.
   [Roh, Sungwon] Hanyang Univ, Coll Med, Dept Psychiat, Seoul, South Korea.
   [Hwang, Jaemin] Korea Univ, Grad Sch Publ Hlth, Seoul, South Korea.
   [Kim, Hyoung Ah] Catholic Univ Korea, Dept Prevent Med, Seoul, South Korea.
   [Kim, Sohye] Seoul Natl Univ, Bundang Hosp, Hlth Promot Ctr, Songnam, South Korea.
   [Lee, Tae Kyung] Natl Ctr Mental Hlth, Dept Addict Psychiat, Seoul, South Korea.
   [Kang, Shi Hyun] Natl Ctr Mental Hlth, Dept Gen Psychiat, Seoul, South Korea.
C3 Hanyang University; Korea University; Korea University Medicine (KU
   Medicine); Catholic University of Korea; Seoul National University (SNU)
RP Park, S (corresponding author), Natl Ctr Mental Hlth, Mental Hlth Res Inst, Dept Res Planning, 127 Youngmasan Ro, Seoul 04933, South Korea.
EM subin-21@hanmail.net
RI Kim, Hanjun/AAJ-7528-2021; Kim, Hyo/AAQ-3152-2020
OI Kim, Sohye/0000-0003-0880-3580; Jang, Jungwon/0000-0002-9702-2809; Ha,
   Yujeong/0000-0002-9109-2240
FU National Center for Mental Health, Ministry of Health Welfare, Korea
   [2012-04]
FX This study was supported by an Intramural Research Grant (No. 2012-04)
   from the National Center for Mental Health, Ministry of Health &
   Welfare, Korea.
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NR 39
TC 29
Z9 29
U1 0
U2 6
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD NOV 15
PY 2016
VL 205
BP 393
EP 399
DI 10.1016/j.jad.2016.08.022
PG 7
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA DY9GC
UT WOS:000385440900051
PM 27588358
DA 2025-06-11
ER

PT J
AU Kim, AW
   Kakuhikire, B
   Baguma, C
   North, CM
   Satinsky, EN
   Perkins, JM
   Ayebare, P
   Kiconco, A
   Namara, EB
   Bangsberg, DR
   Siedner, MJ
   Tsai, AC
AF Kim, Andrew Wooyoung
   Kakuhikire, Bernard
   Baguma, Charles
   North, Crystal M.
   Satinsky, Emily N.
   Perkins, Jessica M.
   Ayebare, Patience
   Kiconco, Allen
   Namara, Elizabeth B.
   Bangsberg, David R.
   Siedner, Mark J.
   Tsai, Alexander C.
TI Adverse childhood experiences and adult cardiometabolic risk factors and
   disease outcomes: Cross-sectional, population-based study of adults in
   rural Uganda
SO JOURNAL OF GLOBAL HEALTH
LA English
DT Article
ID PRENATAL STRESS; BIRTH-WEIGHT; HEALTH; BURDEN; ASSOCIATION; DEPRESSION;
   MORTALITY; AFRICA; ABUSE; DEATH
AB Background Cardiovascular diseases (CVD) pose a major threat to public health in sub-Saharan African communities, where the burden of these classes of illnesses is expected to double by 2030. Growing research suggests that past developmental experiences and early life conditions may also elevate CVD risk throughout the life course. Greater childhood stress and adversity are consistently associated with a range of adult CVDs and associated risk factors, yet little research exists on the long-term effects of early life stress on adult physical health outcomes, especially CVD risk, in sub-Saharan African contexts. This study aims to evaluate the associations between adverse childhood experiences and adult cardiometabolic risk factors and health outcomes in a population-based study of adults living in Mbarara, a rural region of southwestern Uganda.
   Methods Data come from an ongoing, whole-population social network cohort study of adults living in the eight villages of Nyakabare Parish, Mbarara. A modified version of the Adverse Childhood Experiences-International Questionnaire (ACEs) assessed past exposure to physical, emotional, and sexual adversity. Participants also took part in a health fair where medical histories on cardiometabolic risk factors and cardiovascular diseases were gathered. Multiple logistic regression models estimated the associations between ACEs and cardiometabolic risk factors and health outcomes.
   Results Data were available on 545 adults. The average number of ACEs was 4.9 out of a possible 16. The cumulative number of ACEs were associated with having a history of heart attack and/or heart failure (adjusted odds ratio (AOR) = 1.11, 95% confidence interval (CI) = 0.999-1.234, P = 0.051), but the estimated association was not statistically significant. ACEs did not have statistically significant associations with any others measures of adult cardiometabolic risk and CVD.
   Conclusions Adverse childhood experiences are not associated with a range of adult cardiometabolic risk factors and health outcomes in this sample of rural Ugandan adults. Further research in this sample is necessary to identify the pathways that may motivate these null relationship and possibly protect against adverse cardiometabolic and cardiovascular health outcomes.
C1 [Kim, Andrew Wooyoung] Univ Witwatersrand, Fac Hlth Sci, SAMRC Wits Dev Pathways Hlth Res Unit, 29 Princess Wales Terrace, ZA-2193 Johannesburg, South Africa.
   [Kim, Andrew Wooyoung; North, Crystal M.; Satinsky, Emily N.; Siedner, Mark J.; Tsai, Alexander C.] Massachusetts Gen Hosp, Ctr Global Hlth, Boston, MA 02114 USA.
   [Kakuhikire, Bernard; Baguma, Charles; Ayebare, Patience; Kiconco, Allen; Namara, Elizabeth B.; Bangsberg, David R.; Tsai, Alexander C.] Mbarara Univ Sci & Technol, Mbarara, Uganda.
   [North, Crystal M.] Massachusetts Gen Hosp, Div Pulm & Crit Care, Boston, MA 02114 USA.
   [North, Crystal M.; Siedner, Mark J.; Tsai, Alexander C.] Massachusetts Gen Hosp, Mongan Inst, Boston, MA 02114 USA.
   [North, Crystal M.; Siedner, Mark J.; Tsai, Alexander C.] Harvard Med Sch, Boston, MA 02115 USA.
   [Perkins, Jessica M.] Vanderbilt Univ, Peabody Coll, Nashville, TN 37203 USA.
   [Bangsberg, David R.] Oregon Hlth & Sci Univ, Portland State Univ, Sch Publ Hlth, Portland, OR 97201 USA.
   [Siedner, Mark J.] Massachusetts Gen Hosp, Med Practice Evaluat Ctr, Boston, MA 02114 USA.
   [Siedner, Mark J.] Massachusetts Gen Hosp, Div Infect Dis, Boston, MA 02114 USA.
C3 University of Witwatersrand; Harvard University; Harvard University
   Medical Affiliates; Massachusetts General Hospital; Mbarara University
   of Science & Technology; Harvard University; Harvard University Medical
   Affiliates; Massachusetts General Hospital; Harvard University; Harvard
   University Medical Affiliates; Massachusetts General Hospital; Harvard
   University; Harvard Medical School; Vanderbilt University; Vanderbilt
   University Peabody College; Portland State University; Oregon Health &
   Science University; Harvard University; Harvard University Medical
   Affiliates; Massachusetts General Hospital; Harvard University; Harvard
   University Medical Affiliates; Massachusetts General Hospital
RP Kim, AW (corresponding author), Univ Witwatersrand, Fac Hlth Sci, SAMRC Wits Dev Pathways Hlth Res Unit, 29 Princess Wales Terrace, ZA-2193 Johannesburg, South Africa.
EM awkim@mgh.harvard.edu
RI Satinsky, Emily/AAD-3114-2022; Perkins, Jessica/ABG-2467-2020; Kim,
   Andrew/JCD-9167-2023; Tsai, Alexander/F-4247-2015
OI Tsai, Alexander/0000-0001-6397-7917; Satinsky, Emily/0000-0003-0666-6009
FU Friends for a Healthy Uganda; US National Institutes of Health (NIH)
   [R01MH113494, R01MH125667]; US National Science Foundation Graduate
   Research Fellowship; Fogarty International Center; National Institute of
   Mental Health [NIH D43TW010543]
FX This work was supported by Friends for a Healthy Uganda and US National
   Institutes of Health (NIH) [R01MH113494 and R01MH125667]. AWK is
   supported by a US National Science Foundation Graduate Research
   Fellowship and the Fogarty International Center and National Institute
   of Mental Health [NIH D43TW010543]. The content is solely the
   responsibility of the authors and does not necessarily represent the
   official views of the NIH.
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NR 46
TC 5
Z9 5
U1 0
U2 6
PU INT SOC GLOBAL HEALTH
PI EDINBURGH
PA CALEDONIAN EXCHANGE, 19A CANNING ST, EDINBURGH, Lothian, ENGLAND
SN 2047-2978
EI 2047-2986
J9 J GLOB HEALTH
JI J. Glob. Health
PY 2021
VL 11
AR 04035
DI 10.7189/jogh.11.04035
PG 8
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA UK7GG
UT WOS:000692133800035
PM 34386213
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Swann, SA
   King, EM
   Côté, HCF
   Murray, MCM
AF Swann, Shayda A.
   King, Elizabeth M.
   Cote, Helene C. F.
   Murray, Melanie C. M.
TI Stressing the need for validated measures of cortisol in HIV research: A
   scoping review
SO HIV MEDICINE
LA English
DT Review
DE adrenal; cortisol; HIV; review; stress
ID METABOLIC SYNDROME; WOMEN; DIAGNOSIS; INFECTION; MENOPAUSE; HORMONES;
   SYSTEMS; SALIVA; ABUSE
AB Objectives People living with HIV experience numerous endocrine abnormalities and psychosocial stressors. However, interactions between HIV, cortisol levels, and health outcomes have not been well described among people living with HIV on effective therapy. Furthermore, methods for measuring cortisol are disparate across studies. We describe the literature reporting cortisol levels in people living with HIV, describe methods to measure cortisol, and explore how this relates to health outcomes. Methods We searched the PubMed database for articles published in the past 20 years regarding HIV and cortisol with >= 50% of participants on antiretroviral therapies. Articles included observational, case-control, cross-sectional, and randomized controlled trials analyzing cortisol by any method. Studies were excluded if abnormal cortisol was due to medications or other infections. Variables were extracted from selected studies and their quality was assessed using the Newcastle-Ottawa Scale. Results In total, 19 articles were selected and included, covering the prevalence of abnormal cortisol (n = 4), exercise (n = 4), metabolic syndrome and/or cardiovascular disease (n = 2), mental health and cognition (n = 9), and sex/gender (n = 6). Cortisol was measured in serum (n = 7), saliva (n = 8), urine (n = 2), and hair (n = 3) specimens. Comparisons between people with and without HIV were inconsistent, with some evidence that people with HIV have increased rates of hypocortisolism. Depression and cognitive decline may be associated with cortisol excess, whereas anxiety and metabolic disease may be related to low cortisol; more data are needed to confirm these relationships. Conclusions Data on cortisol levels in the era of antiretroviral therapy remain sparse. Future studies should include controls without HIV, appropriately timed sample collection, and consideration of sex/gender and psychosocial factors.
C1 [Swann, Shayda A.; Cote, Helene C. F.; Murray, Melanie C. M.] Univ British Columbia, Dept Expt Med, Vancouver, BC, Canada.
   [Swann, Shayda A.; King, Elizabeth M.; Cote, Helene C. F.; Murray, Melanie C. M.] Womens Hlth Res Inst, Vancouver, BC, Canada.
   [King, Elizabeth M.; Murray, Melanie C. M.] Univ British Columbia, Dept Med, Vancouver, BC, Canada.
   [Cote, Helene C. F.] Univ British Columbia, Dept Pathol & Lab Med, Vancouver, BC, Canada.
   [Cote, Helene C. F.] Univ British Columbia, Ctr Blood Res, Vancouver, BC, Canada.
   [Murray, Melanie C. M.] BC Womens Hosp & Hlth Ctr, Oak Tree Clin, Vancouver, BC, Canada.
C3 University of British Columbia; University of British Columbia;
   University of British Columbia; University of British Columbia
RP Murray, MCM (corresponding author), E600B-4500 Oak St, Vancouver, BC V6H 3N1, Canada.
EM Melanie.Murray@cw.bc.ca
RI Cote, Helene/K-7896-2012
OI Murray, Melanie/0000-0001-9538-2758; Swann, Shayda/0000-0001-7507-3747
FU Canadian Institutes of Health Research; University of British Columbia;
   Michael Smith Foundation for Health Research; Canadian HIV Trials
   Network
FX Canadian Institutes of Health Research; University of British Columbia;
   Michael Smith Foundation for Health Research; Canadian HIV Trials
   Network, Canadian Institutes of Health Research
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NR 56
TC 3
Z9 3
U1 0
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1464-2662
EI 1468-1293
J9 HIV MED
JI HIV Med.
PD SEP
PY 2022
VL 23
IS 8
BP 880
EP 894
DI 10.1111/hiv.13272
EA MAR 2022
PG 15
WC Infectious Diseases
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases
GA 3R3NX
UT WOS:000773408000001
PM 35343039
DA 2025-06-11
ER

PT J
AU Kulak, MJ
   Lewis-de los Angeles, W
   Daniels, TE
   Mathis, KJ
   Gobin, AP
   Laumann, LE
   Beck, Q
   Tyrka, AR
AF Kulak, Meghan J.
   Lewis-de los Angeles, William
   Daniels, Teresa E.
   Mathis, Karen J.
   Gobin, Asi P.
   Laumann, Laura E.
   Beck, Quincy
   Tyrka, Audrey R.
TI Increased Cardiometabolic Risk in Healthy Young Adults With Early Life
   Stress
SO PSYCHOSOMATIC MEDICINE
LA English
DT Article
DE early life stress; childhood maltreatment; childhood adversity; trauma;
   metabolic syndrome; cardiometabolic risk
ID ADVERSE CHILDHOOD EXPERIENCES; FASTING PLASMA-GLUCOSE;
   CORONARY-HEART-DISEASE; METABOLIC SYNDROME; INSULIN-RESISTANCE; PHYSICAL
   ABUSE; UNITED-STATES; VALIDATION; OBESITY; TRAUMA
AB Objective: This study aimed to evaluate the relationship between early life stress (ELS) and metabolic risk in healthy young adults and assess the role of health behaviors. Methods: Young adults aged 18 to 40 years (N = 190) with no medical conditions or medication usage were recruited from the community. Participants with ELS (N = 113) had a history of childhood maltreatment, and most also experienced parental loss (n = 88). Controls (N = 77) had no history of maltreatment or parental loss. Standardized interviews and self-reports assessed demographics, adversity, medical/psychiatric history, and health behaviors. Blood pressure and anthropometrics were measured, and fasting plasma assayed for lipid profiles, glucose, insulin level, and hemoglobin A1c. We calculated both a clinical cut-point and continuous composite metabolic risk score based on clinical risk factors and the mean of z scores of each measure, respectively. Results: ELS was significantly associated with increased clinical cut-point (beta = 0.68, 95% confidence interval [CI] = 0.20-1.17, p = .006) and continuous (beta = 0.23, 95% CI = 0.08-0.038, p = .003) composite metabolic risk scores. On sensitivity analysis, the association of ELS with the continuous composite metabolic risk score was reduced to a trend after adjusting for a range of psychosocial and health predictors (beta = 0.18, 95% CI = 0.00-0.36, p = .053), with both diet and college graduate status significant in the model. Conclusions: Healthy young adults with a history of ELS have increased metabolic risk scores as compared with controls. This relationship may be partially due to health behaviors and socioeconomic factors. These findings underline that ELS is an early contributor to metabolic risk.
C1 [Kulak, Meghan J.; Daniels, Teresa E.; Mathis, Karen J.; Gobin, Asi P.; Laumann, Laura E.; Beck, Quincy; Tyrka, Audrey R.] Brown Univ, Warren Alpert Med Sch, Dept Psychiat & Human Behav, Initiat Stress Trauma & Resilience STAR, Providence, RI USA.
   [Kulak, Meghan J.; Daniels, Teresa E.; Gobin, Asi P.; Laumann, Laura E.; Beck, Quincy; Tyrka, Audrey R.] Butler Hosp, Mood Disorders Res Program, Providence, RI USA.
   [Kulak, Meghan J.; Daniels, Teresa E.; Gobin, Asi P.; Laumann, Laura E.; Beck, Quincy; Tyrka, Audrey R.] Butler Hosp, Lab Clin & Translat Neurosci, Providence, RI USA.
   [Lewis-de los Angeles, William] Hasbro Childrens Hosp, Dept Pediat, Providence, RI USA.
   [Lewis-de los Angeles, William] Bradley Hosp, Providence, RI USA.
   [Lewis-de los Angeles, William] Brown Univ, Warren Alpert Med Sch, Providence, RI USA.
   [Mathis, Karen J.] Univ Rhode Isl, Coll Nursing, Kingston, RI USA.
   [Kulak, Meghan J.] Butler Hosp, 345 Blackstone Blvd, Providence, RI 02906 USA.
C3 Brown University; Butler Hospital Rhode Island; Butler Hospital Rhode
   Island; Hasbro Children's Hospital; Brown University; University of
   Rhode Island; Butler Hospital Rhode Island
RP Kulak, MJ (corresponding author), Butler Hosp, 345 Blackstone Blvd, Providence, RI 02906 USA.
EM meghan_kulak@brown.edu; teresa_daniels@brown.edu;
   karen.mathis@brown.edu; agobin@butler.org; laura.laumann@uconn.edu;
   quincy_beck@alumni.brown.edu; audrey_tyrka@brown.edu
RI Jennings Mathis, Karen/AAK-4766-2020; Laumann, Laura/MGB-5703-2025;
   Tyrka, Audrey/L-2504-2014
OI Tyrka, Audrey/0000-0003-4653-1651; Kulak, Meghan/0000-0001-9857-6013;
   Laumann, Laura/0000-0002-1188-3991; Lewis-de los Angeles,
   William/0000-0003-3858-2299
FU National Institutes of Health [R01MH101107, P20GM139767, R21AG077332];
   National Institute of Mental Health [MH101076]; National Institute of
   Child and Human Development [T32HD101392]
FX Source of Funding and Conflicts of Interest: The authors declare no
   conflicts of interest. This work was supported by National Institutes of
   Health grants R01MH101107 (A.R.T.), and Dr. Tyrka's time was
   additionally supported by P20GM139767 and R21AG077332. Dr. Teresa
   Daniels and Dr. Meghan Kulak received support from National Institute of
   Mental Health grant MH101076 (A.R.T.), and Dr. Daniels also received
   support from the National Institute of Child and Human Development grant
   T32HD101392 (A.R.T.). Dr. William Lewis-de los Angeles and Dr. Audrey
   Tyrka also received support from the Hasbro/Bradley Pilot Clinical
   Research Award from Lifespan.
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NR 70
TC 2
Z9 2
U1 1
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0033-3174
EI 1534-7796
J9 PSYCHOSOM MED
JI Psychosom. Med.
PD FEB-MAR
PY 2024
VL 86
IS 2
BP 72
EP 82
DI 10.1097/PSY.0000000000001273
PG 11
WC Psychiatry; Psychology; Psychology, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry; Psychology
GA HK3V1
UT WOS:001159365200009
PM 38153259
DA 2025-06-11
ER

PT J
AU Ruttle, PL
   Klein, MH
   Slattery, MJ
   Kalin, NH
   Armstrong, JM
   Essex, MJ
AF Ruttle, Paula L.
   Klein, Marjorie H.
   Slattery, Marcia J.
   Kalin, Ned H.
   Armstrong, Jeffrey M.
   Essex, Marilyn J.
TI Adolescent adrenocortical activity and adiposity: Differences by sex and
   exposure to early maternal depression
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE Adiposity; Adolescence; Body mass index (BMI); Early maternal
   depression; Morning cortisol; Obesity; Reactive cortisol; Sex
   differences
ID PITUITARY-ADRENAL-AXIS; BODY-MASS INDEX; SALIVARY CORTISOL;
   MENTAL-HEALTH; ACADEMIC DIFFICULTIES; METABOLIC SYNDROME; CHILDHOOD
   OBESITY; MIDDLE CHILDHOOD; DIURNAL CORTISOL; CHRONIC STRESS
AB Prior research has linked either basal cortisol levels or stress-induced cortisol responses to adiposity; however, it remains to be determined whether these distinct cortisol measures exert joint or independent effects. Further, it is unclear how they interact with individual and environmental characteristics to predict adiposity. The present study aims to address whether morning cortisol levels and cortisol responses to a psychosocial stressor independently and/or interactively influence body mass index (BMI) in 218 adolescents (117 female) participating in a longitudinal community study, and whether associations are moderated by sex and exposure to early maternal depression. Reports of maternal depressive symptoms were obtained in infancy and preschool. Salivary cortisol measures included a longitudinal morning cortisol measure comprising sampling points across ages 11, 13, 15, and 18 and measures of stress-induced cortisol responses assessed via the Trier Social Stress Test (TSST) at age 18. Lower morning cortisol and higher TSST cortisol reactivity independently predicted higher age 18 BMI. Morning cortisol also interacted with sex and exposure to early maternal depression to predict BMI. Specifically, girls exposed to lower levels of early maternal depression displayed a strong negative morning cortisol BMI association, and girls exposed to higher levels of maternal depression demonstrated a weaker negative association. Among boys, those exposed to lower levels of maternal depression displayed no association, while those exposed to higher levels of maternal depression displayed a negative morning cortisol BMI association. Results point to the independent, additive effects of morning and reactive cortisol in the prediction of BMI and suggest that exposure to early maternal depression may exert sexually dimorphic effects on normative cortisol BMI associations. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Ruttle, Paula L.; Klein, Marjorie H.; Slattery, Marcia J.; Kalin, Ned H.; Armstrong, Jeffrey M.; Essex, Marilyn J.] Univ Wisconsin, Sch Med & Publ Hlth, Dept Psychiat, Madison, WI 53719 USA.
C3 University of Wisconsin System; University of Wisconsin Madison
RP Ruttle, PL (corresponding author), Univ Wisconsin, Sch Med & Publ Hlth, Dept Psychiat, 6001 Res Pk Blvd, Madison, WI 53719 USA.
EM ruttle@wisc.edu
OI Kalin, Ned/0000-0003-1184-0868
FU NIH [R01-MH044340, P50-MH052354, P50-MH069315, P50-MH084051,
   R21-MH082705, UL1-RR025011]; HealthEmotions Research Institute; Robert
   Wood Johnson Foundation Health Et Society Scholars Program; University
   of Wisconsin Madison; John D. and Catherine T. MacArthur Foundation
   Research Network on Psychopathology and Development; Clinical and
   Translational Science Award (CTSA) program, through the NIH (National
   Center for Advancing Translational Sciences NCATS) [UL1TR000427];
   Canadian Institutes of Health Research Post-doctoral Fellowship
FX This research was supported by NIH grants R01-MH044340, P50-MH052354,
   P50-MH069315, P50-MH084051, R21-MH082705, and UL1-RR025011; the
   HealthEmotions Research Institute and the Robert Wood Johnson Foundation
   Health Et Society Scholars Program, both at the University of Wisconsin
   Madison; and the John D. and Catherine T. MacArthur Foundation Research
   Network on Psychopathology and Development. MJS was also supported by
   the Clinical and Translational Science Award (CTSA) program, through the
   NIH (National Center for Advancing Translational Sciences NCATS), grant
   UL1TR000427. The content is solely the responsibility of the authors and
   does not necessarily represent the official views of the NIH. Partial
   support for PLR was provided by the Canadian Institutes of Health
   Research Post-doctoral Fellowship.
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NR 52
TC 16
Z9 20
U1 0
U2 21
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD SEP
PY 2014
VL 47
BP 68
EP 77
DI 10.1016/j.psyneuen.2014.04.025
PG 10
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA AM2PY
UT WOS:000339694500008
PM 25001956
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Vaghef-Mehrabani, E
   Izadi, A
   Ebrahimi-Mameghani, M
AF Vaghef-Mehrabani, Elnaz
   Izadi, Azimeh
   Ebrahimi-Mameghani, Mehrangiz
TI The association of depression with metabolic syndrome parameters and
   malondialdehyde (MDA) in obese women: A case-control study
SO HEALTH PROMOTION PERSPECTIVES
LA English
DT Article
DE Insulin resistance; Major; depressive disorder; Malondialdehyde;
   Metabolic; syndrome; Obesity; Oxidative; stress
ID TERM ANTIDEPRESSANT TREATMENT; OXIDATIVE STRESS; 1ST EPISODE; DISORDER;
   HEALTH; RISK; SYMPTOMS; ANXIETY; SAMPLES
AB Background: There is evidence for a bidirectional association between obesity and depression, and obesity is the main risk factor for metabolic syndrome (MetS). This study aimed to compare oxidative stress and MetS features between depressed and non-depressed obese women and study the association of depressive symptoms, oxidative stress, and components of MetS.
   Methods: In this case-control study conducted in Tabriz (East Azarbaijan, Iran), obese women (body mass index [BMI]: 30-40 kg/m(2)) with a primary diagnosis of major depressive disorder (MDD; based on diagnostic interview with a psychiatrist; n = 75) and their age-matched nondepressed controls (n = 150) were enrolled. Beck Depression Inventory-version II (BDI-II) was used to assess depressive symptoms in both groups. Anthropometric parameters, blood pressure, fasting blood sugar (FBS), lipid profile and malondialdehyde (MDA) were measured.
   Results: No significant differences in anthropometric parameters and blood pressure were observed between the two groups. However, FBS of the MDD group was significantly higher than the control (P < 0.05). FBS was significantly correlated with BDI-II scores (r = 0.158, P = 0.017). No significant difference in lipid profile was observed between the groups. Serum MDA level was significantly lower in the MDD group and was inversely associated with BDI-II scores (r=-0.328, P < 0.001). Overall, MDD was not significantly associated with MetS in our study (OR = 0.848, 95% CI: 0.484, 1.487; P= 0.566).
   Conclusion: Although we found a correlation between higher depressive symptoms and some adverse metabolic outcomes, our findings do not support a significant association between MDD and MetS.
C1 [Vaghef-Mehrabani, Elnaz] Univ Calgary, Cumming Sch Med, Dept Pediat, Calgary, AB, Canada.
   [Izadi, Azimeh] Tabriz Univ Med Sci, Sch Nutr & Food Sci, Dept Biochem & Diet Therapy, Tabriz, Iran.
   [Ebrahimi-Mameghani, Mehrangiz] Tabriz Univ Med Sci, Nutr Res Ctr, Sch Nutr & Food Sci, Dept Biochem & Diet Therapy, Tabriz, Iran.
C3 University of Calgary; Tabriz University of Medical Science; Tabriz
   University of Medical Science
RP Ebrahimi-Mameghani, M (corresponding author), Tabriz Univ Med Sci, Nutr Res Ctr, Sch Nutr & Food Sci, Dept Biochem & Diet Therapy, Tabriz, Iran.
EM ebrahimimamagani@tbzmed.ac.ir
RI Izadi, Azimeh/K-6025-2018; Ebrahimi-Mameghani, Mehrangiz/G-6461-2017
OI Vaghef Mehrabani, Elnaz/0000-0003-0890-2618; Ebrahimi-Mameghani,
   Mehrangiz/0000-0002-0311-1289
FU "Nutrition Research Center" of Tabriz University of Medical Sciences,
   Tabriz, Iran
FX This work was funded by the "Research Vice-Chancellor" and "Nutrition
   Research Center" of Tabriz University of Medical Sciences, Tabriz, Iran.
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NR 40
TC 3
Z9 3
U1 1
U2 2
PU TABRIZ UNIV MEDICAL SCIENCES & HEALTH SERVICES
PI TABRIZ
PA DANESHGHAH ST, TABRIZ, REPUBLIC ISLAMIC 51664-14766, IRAN
SN 2228-6497
J9 HEALTH PROMOT PERSPE
JI Health Promot. Perspect.
PY 2021
VL 11
IS 4
BP 492
EP 497
DI 10.34172/hpp.2021.62
PG 6
WC Public, Environmental & Occupational Health
WE Emerging Sources Citation Index (ESCI)
SC Public, Environmental & Occupational Health
GA XU3TO
UT WOS:000734191900016
PM 35079595
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Correia-Costa, L
   Sousa, T
   Morato, M
   Cosme, D
   Afonso, J
   Areias, JC
   Schaefer, F
   Guerra, A
   Afonso, AC
   Azevedo, A
   Albino-Teixeira, A
AF Correia-Costa, Liane
   Sousa, Teresa
   Morato, Manuela
   Cosme, Dina
   Afonso, Joana
   Areias, Jose C.
   Schaefer, Franz
   Guerra, Antonio
   Afonso, Alberto C.
   Azevedo, Ana
   Albino-Teixeira, Antonio
TI Oxidative stress and nitric oxide are increased in obese children and
   correlate with cardiometabolic risk and renal function
SO BRITISH JOURNAL OF NUTRITION
LA English
DT Article
DE Paediatric obesity; Oxidative stress; Nitric oxide; Risk factors;
   Glomerular filtration rate
ID DIET-INDUCED OBESITY; INSULIN-RESISTANCE; CARDIOVASCULAR RISK; METABOLIC
   SYNDROME; LIFE-STYLE; HYPERTENSION; ADOLESCENTS; CHILDHOOD; MARKERS;
   DISEASE
AB Oxidative stress and nitric oxide (NO) appear to represent important links between obesity and cardiovascular, metabolic and/or renal disease. We investigated whether oxidative stress and NO production/metabolism are increased in overweight and obese prepubertal children and correlate with cardiometabolic risk and renal function. We performed a cross-sectional evaluation of 313 children aged 8-9 years. Anthropometrics, 24-h ambulatory blood pressure, pulse wave velocity (PWV), insulin resistance (homoeostasis model assessment index (HOMA-IR)), inflammatory/metabolic biomarkers, estimated glomerular filtration rate (eGFR), plasma total antioxidant status (TAS), plasma and urinary isoprostanes (P-Isop, U-Isop), urinary hydrogen peroxide (U-H2O2), and plasma and urinary nitrates and nitrites (P-NOx, U-NOx) were compared among normal weight, overweight and obese groups, according to WHO BMI z-score reference. U-Isop were increased in the obese group, whereas U-NOx were increased in both overweight and obese children. U-Isop were positively correlated with U-H2O2, myeloperoxidase (MPO), high-sensitivity C-reactive protein, HOMA-IR and TAG. TAS correlated negatively with U-Isop and MPO and positively with PWV. HOMA-IR and U-H2O2 were associated with higher U-Isop, independently of BMI and eGFR, and total cholesterol and U-H2O2 were associated with U-NOx, independently of BMI, eGFR values and P-NOx concentration. In overweight and obese children, eGFR decreased across P-NOx tertiles (median: 1393 (25th, 75th percentile 1280, 1465), 1280 (25th, 75th percentile 1215, 1404), 1295 (25th, 75th percentile 1194, 1383), P-for linear trend=0003). We conclude that oxidant status and NO are increased in relation to fat accumulation and, even in young children, they translate into higher values of cardiometabolic risk markers and affect renal function.
C1 [Correia-Costa, Liane; Cosme, Dina; Afonso, Alberto C.; Azevedo, Ana] Univ Porto, EPIUnit, Inst Publ Hlth, Rua Taipas 135, P-4050600 Oporto, Portugal.
   [Correia-Costa, Liane; Afonso, Alberto C.] Integrated Pediat Hosp, Div Pediat Nephrol, Ctr Hos Sao Joao, Alameda Prof Hernani Monteiro, P-4200319 Oporto, Portugal.
   [Correia-Costa, Liane; Areias, Jose C.; Guerra, Antonio; Afonso, Alberto C.] Univ Porto, Dept Pediat, Fac Med, Alameda Prof Hernani Monteiro, P-4200319 Oporto, Portugal.
   [Sousa, Teresa; Morato, Manuela; Cosme, Dina; Afonso, Joana; Albino-Teixeira, Antonio] Univ Porto, Dept Pharmacol & Therapeut, Fac Med, Rua Dr Placido da Costa 91, P-4200450 Oporto, Portugal.
   [Sousa, Teresa; Morato, Manuela; Afonso, Joana; Albino-Teixeira, Antonio] Univ Porto, MedInUP Ctr Drug Discovery & Innovat Med, Alameda Prof Hernani Monteiro, P-4200319 Oporto, Portugal.
   [Morato, Manuela] Univ Porto, Fac Pharm Porto, Dept Drug Sci, Pharmacol Lab, Rua Jorge Viterbo Ferreira 228, P-4050313 Oporto, Portugal.
   [Areias, Jose C.] Integrated Pediat Hosp, Div Pediat Cardiol, Ctr Hospitalar Sao Joao, Alameda Prof Hernani Monteiro, P-4200319 Oporto, Portugal.
   [Schaefer, Franz] Heidelberg Univ, Div Pediat Nephrol, Ctr Pediat & Adolescent Med, Neuenheimer Feld 430, D-69120 Heidelberg, Germany.
   [Guerra, Antonio] Integrated Pediat Hosp, Div Pediat Nutr, Ctr Hosp Sao Joao, Alameda Prof Hernani Monteiro, P-4200319 Oporto, Portugal.
   [Azevedo, Ana] Univ Porto, Fac Med, Dept Clin Epidemiol Predict Med & Publ Hlth, Alameda Prof Hernani Monteiro, P-4200319 Oporto, Portugal.
C3 Universidade do Porto; Universidade do Porto; Universidade do Porto;
   Universidade do Porto; Universidade do Porto; Sao Joao Hospital;
   Ruprecht Karls University Heidelberg; Sao Joao Hospital; Universidade do
   Porto
RP Sousa, T (corresponding author), Univ Porto, Dept Pharmacol & Therapeut, Fac Med, Rua Dr Placido da Costa 91, P-4200450 Oporto, Portugal.; Sousa, T (corresponding author), Univ Porto, MedInUP Ctr Drug Discovery & Innovat Med, Alameda Prof Hernani Monteiro, P-4200319 Oporto, Portugal.
EM tsousa@med.up.pt
RI Morato, Manuela/D-7563-2013; Correia-Costa, Liane/JPA-4135-2023; ,
   Teresa/HSF-0698-2023; Afonso, Carlos/M-7833-2013; Azevedo,
   Ana/AAA-2287-2020; Afonso, Joana/A-4395-2016; Albino-Teixeira,
   Antonio/HPI-0713-2023
OI Albino-Teixeira, Antonio/0000-0003-0097-2953; Schaefer,
   Franz/0000-0001-7564-9937; Azevedo, Ana/0000-0002-7368-9609; Cosme,
   Dina/0000-0002-8398-0184; Morato, Manuela/0000-0002-9509-0613; Caldas
   Afonso, Alberto/0000-0002-2574-4132; Sousa, Teresa/0000-0001-7230-5020;
   Correia-Costa, Liane/0000-0002-8216-090X; Areias, Jose
   Carlos/0000-0002-9833-2518
FU Fundo Europeu de Desenvolvimento Regional (FEDER) funds from Programa
   Operacional Factores de Competitividade - COMPETE
   [FCOMP-01-0124-FEDER-028751]; Portuguese Foundation for Science and
   Technology (FCT), Lisbon, Portugal [PTDC/DTP-PIC/0239/2012]; Calouste
   Gulbenkian Foundation; FCT [SFRH/SINTD/95898/2013]; Programa Operacional
   Potencial Humano (POPH)/Fundo Social Europeu (FSE) (EC)
   [SFRH/BPD/112005]; European Renal Association - European Dialysis and
   Transplant Association Research Programme, Parma, Italy; KfH Foundation
   for Preventive Medicine, Neu-Isenburg, Germany; COMPETE; POPH/FSE (EC);
   European Renal Association; KfH Foundation for Preventive Medicine;
   Fundação para a Ciência e a Tecnologia [SFRH/SINTD/95898/2013,
   PTDC/DTP-PIC/0239/2012] Funding Source: FCT
FX This project was supported by the Fundo Europeu de Desenvolvimento
   Regional (FEDER) funds from Programa Operacional Factores de
   Competitividade - COMPETE (FCOMP-01-0124-FEDER-028751), by national
   funds from the Portuguese Foundation for Science and Technology (FCT),
   Lisbon, Portugal (PTDC/DTP-PIC/0239/2012), and by Calouste Gulbenkian
   Foundation. L. C.- C. was supported by FCT (grant
   SFRH/SINTD/95898/2013), T. S. was supported by FCT and Programa
   Operacional Potencial Humano (POPH)/Fundo Social Europeu (FSE) (EC)
   (Ciencia 2008 and SFRH/BPD/112005) and F. S. was supported by the
   European Renal Association - European Dialysis and Transplant
   Association Research Programme, Parma, Italy, and the KfH Foundation for
   Preventive Medicine, Neu-Isenburg, Germany. The funders COMPETE, FCT,
   Calouste Gulbenkian Foundation, POPH/FSE (EC), European Renal
   Association and KfH Foundation for Preventive Medicine had no role in
   the design, analysis or writing of this article.
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NR 55
TC 33
Z9 35
U1 0
U2 15
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1145
EI 1475-2662
J9 BRIT J NUTR
JI Br. J. Nutr.
PD SEP 14
PY 2016
VL 116
IS 5
BP 805
EP 815
DI 10.1017/S0007114516002804
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA DV4KM
UT WOS:000382894500005
PM 27480380
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Doom, JR
   Deer, LK
   Mickel, T
   Infante, A
   Rivera, KM
AF Doom, Jenalee R.
   Deer, LillyBelle K.
   Mickel, Trudy
   Infante, Andrea
   Rivera, Kenia M.
TI Eating Behaviors as Pathways From Early Childhood Adversity to
   Adolescent Cardiometabolic Risk
SO HEALTH PSYCHOLOGY
LA English
DT Article
DE Avon Longitudinal Study of Parents and Children; childhood adversity;
   adolescence; eating behavior; cardiometabolic risk
ID EMOTION DYSREGULATION; SCIENTIFIC STATEMENT; MATERNAL DEPRESSION;
   LIFE-SPAN; STRESS; CHILDREN; SYMPTOMS; INDEXES; TRAUMA; HEALTH
AB Objective: To identify specific eating behavior pathways that mediate associations between financial difficulties, negative life events, and maternal depressive symptoms from 0 to 5 years and cardiometabolic risk in adolescence. Method: Hypotheses were tested with data from birth to age 15 years using the Avon Longitudinal Study of Parents and Children, a birth cohort in the United Kingdom (n = 3,887 for current analyses). Mothers reported on financial difficulties, negative life events, and maternal depressive symptoms at multiple points from 0 to 5 years and reported on worry about child overeating at 8 years. Youth self-reported restrained, emotional, and external eating at age 14. Youth completed a cardiometabolic health assessment at age 15 where waist circumference, triglycerides, high-density lipoprotein, and insulin resistance were measured. Longitudinal structural equation modeling with bootstrapping was used to test mediation models. Results: Greater negative life events and maternal depressive symptoms predicted greater parental worry about child overeating at age 8, which directly predicted greater restrained and emotional eating at 14 and cardiometabolic risk at 15. Restrained and emotional eating at 14 directly predicted greater cardiometabolic risk at age 15. Conclusions: Negative life events and maternal depressive symptoms in infancy/early childhood are associated with cardiometabolic risk in adolescence through pathways of parental worry about child overeating in middle childhood and youth-reported restrained and emotional eating in adolescence.
C1 [Doom, Jenalee R.; Deer, LillyBelle K.; Mickel, Trudy; Infante, Andrea; Rivera, Kenia M.] Univ Denver, Dept Psychol, Denver, CO 80210 USA.
C3 University of Denver
RP Doom, JR (corresponding author), Univ Denver, Dept Psychol, Denver, CO 80210 USA.
EM jena.doom@du.edu
RI Deer, LillyBelle/W-9369-2019
OI Doom, Jenalee/0000-0003-2857-0817
FU U.K. Medical Research Council; Wellcome [217065/Z/19/Z]; University of
   Bristol; National Heart, Lung, And Blood Institute [K01HL143159,
   F32HL165844]
FX The U.K. Medical Research Council and Wellcome (Grant 217065/Z/19/Z)and
   the University of Bristol provide core support for Avon Longitudinal
   Study of Parents and Children (ALSPAC). A comprehensive list of grants
   funding is available on the ALSPAC website
   (https://www.bristol.ac.uk/alspac/external/documents/grant-acknowledgeme
   nts. pdf). This publication is the work of the authors (Jenalee R. Doom,
   LillyBelle K. Deer, Trudy Mickel, Andrea Infante, and Kenia M. Rivera),
   who will serve as guarantors for the contents of this article. Jenalee
   R. Doom and LillyBelle K. Deer were supported by the National Heart,
   Lung, And Blood Institute (K01HL143159,principal investigator: Jenalee
   R. Doom; F32HL165844, principal investigator: LillyBelle K. Deer). The
   authors are grateful to all the families whotook part in this study, the
   midwives for their help in recruiting them, and the whole ALSPAC team,
   which includes interviewers, computer and laboratory technicians,
   clerical workers, research scientists, volunteers,
   managers,receptionists, and nurses. The authors have no conflicts of
   interest to disclose.This research was funded in whole, or in part, by
   the The UK MedicalResearch Council and Wellcome [Grant 217065/Z/19/Z].
   For the purposeof open access, the author has applied a CC BY public
   copyright license toany Author Accepted Manuscript version arising from
   this submission.
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NR 89
TC 5
Z9 5
U1 4
U2 10
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 0278-6133
EI 1930-7810
J9 HEALTH PSYCHOL
JI Health Psychol.
PD JUN
PY 2024
VL 43
IS 6
BP 448
EP 461
DI 10.1037/hea0001340
EA FEB 2024
PG 14
WC Psychology, Clinical; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology
GA I0O8U
UT WOS:001174326200001
PM 38407101
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Grossniklaus, DA
   Gary, RA
   Higgins, MK
   Dunbar, SB
AF Grossniklaus, Daurice A.
   Gary, Rebecca A.
   Higgins, Melinda K.
   Dunbar, Sandra B.
TI Biobehavioral and Psychological Differences Between Overweight Adults
   With and Without Waist Circumference Risk
SO RESEARCH IN NURSING & HEALTH
LA English
DT Article
DE obesity; depression; lifestyle change; prevention
ID VISCERAL ADIPOSE-TISSUE; BODY-FAT DISTRIBUTION; METABOLIC SYNDROME;
   INSULIN-RESISTANCE; ABDOMINAL OBESITY; CORTISOL; DEPRESSION;
   ADIPONECTIN; HEALTH; MEN
AB Waist circumference (WC) has emerged as an independent predictor of cardiometabolic disease. The purpose of this study was to examine differences between overweight adults with and without WC risk in four domains: demographic, clinical and biological, psychological, and behavioral. The sample (N = 87) was primarily sedentary, middle-aged, women, and African-Americans. The majority of participants had WC risk, those with WC risk were older, were women, and had higher body mass index, higher morning salivary cortisol levels, and more depressive symptoms than those without WC risk. Caloric and macronutrient intake did not differ between those with and without WC risk. Our findings could lead to the development of targeted interventions to prevent and/or reduce abdominal obesity, thereby reducing cardiometabolic risk. (C) 2010 Wiley Periodicals, Inc. Res Nurs Health 33:539-551, 2010
C1 [Gary, Rebecca A.; Higgins, Melinda K.; Dunbar, Sandra B.] Emory Univ, Nell Hodgson Woodruff Sch Nursing, Atlanta, GA 30322 USA.
C3 Emory University
RP Grossniklaus, DA (corresponding author), 1836 Grist Stone Ct, Atlanta, GA 30307 USA.
RI Higgins, Melinda/B-6459-2013
OI Higgins, Melinda/0000-0001-6579-5885
FU National Institutes of Health; National Institute for Nursing Research;
   National Research Service Award [1F31, NR010159-01A1]; Nurses
   Educational Funds, Inc.; American Nurses Foundation; Southern Nurses
   Research Society; Sigma Theta Tau International, Alpha Epsilon Chapter;
   National Center for Research Resources [UL1RR025008]; Clinical and
   Translational Science [MO1 RR0039]; General Clinical Research Center
FX Contract grant sponsor: National Institutes of Health.Contract grant
   sponsor: National Institute for Nursing Research.Contract grant sponsor:
   National Research Service Award 1F31; Contract grant number:
   NR010159-01A1.Contract grant sponsor: Nurses Educational Funds,
   Inc.Contract grant sponsor: American Nurses Foundation.Contract grant
   sponsor: Southern Nurses Research Society.Contract grant sponsor: Sigma
   Theta Tau International, Alpha Epsilon Chapter.Contract grant sponsor:
   National Institutes of Health.Contract grant sponsor: National Center
   for Research Resources PHS Grant; Contract grant number:
   UL1RR025008.Contract grant sponsor: Clinical and Translational Science
   Award Program and PHS Grant; Contract grant number: MO1 RR0039.Contract
   grant sponsor: General Clinical Research Center Program.
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NR 60
TC 9
Z9 12
U1 0
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0160-6891
EI 1098-240X
J9 RES NURS HEALTH
JI Res. Nurs. Health
PD DEC
PY 2010
VL 33
IS 6
BP 539
EP 551
DI 10.1002/nur.20411
PG 13
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA 677ZP
UT WOS:000284037000007
PM 21053387
OA Green Submitted, Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Lei, WY
   Yu, HC
   Wen, SH
   Liu, TT
   Yi, CH
   Wang, CC
   Hsu, CS
   Chen, CH
   Chen, CL
   Pace, F
AF Lei, Wei-Yi
   Yu, Hao-Chun
   Wen, Shu-Hui
   Liu, Tso-Tsai
   Yi, Chih-Hsun
   Wang, Chia-Chi
   Hsu, Ching-Sheng
   Chen, Chien-Hwa
   Chen, Chien-Lin
   Pace, Fabio
TI Predictive factors of silent reflux in subjects with erosive esophagitis
SO DIGESTIVE AND LIVER DISEASE
LA English
DT Article
DE Erosive esophagitis; Gastroesophageal reflux; Silent reflux
ID QUALITY-OF-LIFE; GASTROESOPHAGEAL-REFLUX; BARRETTS-ESOPHAGUS;
   RISK-FACTORS; CHINESE POPULATION; METABOLIC SYNDROME; CLINICAL
   CHARACTERISTICS; PSYCHOLOGICAL-FACTORS; GENERAL-POPULATION; SLEEP
   QUALITY
AB Background: Asymptomatic erosive esophagitis by definition is a condition lacking any reflux symptom. Aims: We aimed to investigate the prevalence of asymptomatic erosive esophagitis in a general population undergoing periodic health checkup.
   Methods: Consecutive subjects undergoing a medical checkup were enrolled for evaluation of reflux disease with upper endoscopy and a validated reflux questionnaire. The presence and severity of erosive esophagitis were evaluated. In all subjects, demographic characteristics and biochemical data were recorded, and sleep and psychological characteristics were assessed by means of self-administered Pittsburgh Sleep Quality Index score, Taiwanese Depression Questionnaire score, and State-Trait Anxiety Inventory score.
   Results: Of 2568 subjects eligible for this study, erosive esophagitis was found in 676 subjects (26.3%), in whom the proportions of asymptomatic and symptomatic erosive esophagitis were 59.2% (400 subjects) and 40.8% (276 subjects) respectively. At a univariate analysis, it was found that asymptomatic erosive esophagitis subjects were more frequently of female gender, of older age, with a lower level of education. They also showed less alcohol and tea consumption, less depression, less anxiety, lower serum level of triglyceride, and lower prevalence of metabolic syndrome. Multivariate analysis revealed that female sex (OR = 1.645, p = 0.0146) was a positive predictive factor for asymptomatic erosive esophagitis, whereas higher level of education (OR = 0.564, p = 0.044), higher Taiwanese Depression Questionnaire score (OR = 0.922, p < 0.001), and the presence of metabolic syndrome (OR = 0.625, p = 0.0379) were negative predictive factors.
   Conclusions: Asymptomatic erosive esophagitis is a common feature in otherwise healthy subjects and is independently associated with female gender, lower education level, less depression, and lower prevalence of metabolic syndrome. (C) 2014 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.
C1 [Lei, Wei-Yi; Yu, Hao-Chun; Liu, Tso-Tsai; Yi, Chih-Hsun; Chen, Chien-Lin] Buddhist Tzu Chi Med Fdn, Hualien Tzu Chi Hosp, Dept Med, Hualien, Taiwan.
   [Lei, Wei-Yi; Liu, Tso-Tsai; Yi, Chih-Hsun; Chen, Chien-Lin] Tzu Chi Univ, Sch Med, Hualien, Taiwan.
   [Wen, Shu-Hui] Tzu Chi Univ, Coll Med, Dept Publ Hlth, Hualien, Taiwan.
   [Wang, Chia-Chi; Hsu, Ching-Sheng; Chen, Chien-Hwa] Buddhist Tzu Chi Med Fdn, Taipei Tzu Chi Hosp, Dept Internal Med, Div Gastroenterol & Hepatol, Hualien, Taiwan.
   [Wang, Chia-Chi; Hsu, Ching-Sheng; Chen, Chien-Hwa] Tzu Chi Univ, Sch Med, Hualien, Taiwan.
   [Pace, Fabio] L Sacco Univ Hosp, Dept Clin Sci, Div Gastroenterol, Milan, Italy.
C3 Buddhist Tzu Chi General Hospital; Hualien Tzu Chi Hospital; Tzu Chi
   University; Tzu Chi University; Tzu Chi University; University of Milan;
   Luigi Sacco Hospital
RP Chen, CL (corresponding author), Buddhist Tzu Chi Med Fdn, Hualien Tzu Chi Hosp, Dept Med, 707,Sect 3,Chung Yang Rd, Hualien, Taiwan.
EM harry.clchen@msa.hinet.net
RI Lei, Wei-Yi/AAW-8292-2020
OI Wen, Shu-Hui/0000-0003-1402-9114; Chen, Chien-Lin/0000-0002-9084-8210
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NR 43
TC 20
Z9 21
U1 1
U2 10
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1590-8658
EI 1878-3562
J9 DIGEST LIVER DIS
JI Dig. Liver Dis.
PD JAN
PY 2015
VL 47
IS 1
BP 24
EP 29
DI 10.1016/j.dld.2014.09.017
PG 6
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA AX3KJ
UT WOS:000346838000008
PM 25308612
DA 2025-06-11
ER

PT J
AU Byrne, DG
   Espnes, GA
AF Byrne, D. G.
   Espnes, Geir Arild
TI Occupational stress and cardiovascular disease
SO STRESS AND HEALTH
LA English
DT Article
DE occupation; stress; cardiovascular disease
ID CORONARY-HEART-DISEASE; EFFORT-REWARD IMBALANCE; MYOCARDIAL-INFARCTION
   RISK; PSYCHOSOCIAL WORK-ENVIRONMENT; JOB STRAIN; BLOOD-PRESSURE;
   DECISION LATITUDE; METABOLIC SYNDROME; PSYCHOLOGICAL STRESS; PERCEIVED
   STRESS
AB Links between occupational stress and cardiovascular risk have long been asserted. This paper reviews the evidence from the simple notion of occupational level and type as a risk through to the more theoretically sophisticated models of occupational stress as a determinant of cardiovascular risk and disease. It maps measures of occupational stress against the three related end points of coronary risk profiles, hypertension and clinical cardiovascular disease. Taken broadly, the evidence is supportive of postulated links. The persuasiveness of the evidence now points to intervention studies in the workplace as the next major focus of research. Copyrigbt (C) 2008 John Wiley & Sons, Ltd.
C1 [Byrne, D. G.] Australian Natl Univ, Sch Psychol, Canberra, ACT 0200, Australia.
   [Espnes, Geir Arild] Norwegian Univ Sci & Technol, Sch Social Work & Hlth Sci, Trondheim, Norway.
C3 Australian National University; Norwegian University of Science &
   Technology (NTNU)
RP Byrne, DG (corresponding author), Australian Natl Univ, Sch Psychol, GPO Box 4, Canberra, ACT 0200, Australia.
EM don.byrne@anu.edu.au
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NR 77
TC 39
Z9 56
U1 1
U2 54
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1532-3005
EI 1532-2998
J9 STRESS HEALTH
JI Stress Health
PD AUG
PY 2008
VL 24
IS 3
BP 231
EP 238
DI 10.1002/smi.1203
PG 8
WC Psychology, Applied; Psychiatry; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA 353QY
UT WOS:000259584500009
DA 2025-06-11
ER

PT J
AU Mujkanovic, J
   Warming, PE
   Kessing, LV
   Kober, LV
   Winkel, BG
   Lynge, TH
   Tfelt-Hansen, J
AF Mujkanovic, Jasmin
   Warming, Peder Emil
   Kessing, Lars Vedel
   Kober, Lars Valeur
   Winkel, Bo Gregers
   Lynge, T. H.
   Tfelt-Hansen, Jacob
TI Nationwide burden of sudden cardiac death among patients with a
   psychiatric disorder
SO HEART
LA English
DT Article
DE SUDDEN CARDIAC DEATH; Epidemiology; Quality of Health Care; Risk
   Factors; Metabolic Syndrome
ID SCHIZOPHRENIA; DEPRESSION; MORTALITY; GENDER; RISK
AB Background Patients with psychiatric disorders have increased all-cause mortality compared with the general population. Previous research has shown that there is a fourfold increased risk of sudden cardiac death (SCD) among the young. Objective To investigate the incidence of SCD in patients with psychiatric disorders aged 18-90 years in the Danish population by systematically reviewing all deaths in 1 year. Methods We examined all deaths in Denmark among residents aged 18-90 years in 2010 by reviewing death certificates and autopsy reports. All deaths were categorised as non-SCD or SCD based on the available information. Psychiatric disorder was defined according to International Classification of Diseases, 10th revision criteria or by redemption of a prescription for psychotropic medication within 1 year. Results Of 4.3 million residents in 2010, we observed 45 703 deaths, of which 6002 were due to SCD. Overall, the incidence rate ratio of SCD was 1.79-6.45 times higher among patients with psychiatric disorders than in the general population and was age dependent (p<0.001 across all age groups). When adjusting for age, sex and comorbidities, psychiatric disorders were independently associated with SCD, with a HR of 2.31 (2.19 to 2.43, p<0.001), and HR was highest among patients with schizophrenic disorders, with a HR of 4.51 (3.95 to 5.16, p <0.001). Furthermore, 18-year-old patients with a psychiatric disorder had an expected 10-year excess loss of life. Patients aged 18-40 with a psychiatric disorder had 13% of excess life years lost caused by SCD. Conclusion In this study, the rate of SCD in patients with psychiatric disorders is higher across all age groups than in the general population. Having a psychiatric disorder is independently associated with SCD. Patients with schizophrenic disease had the highest rates of SCD. Life expectancy for an 18-year old with a psychiatric disorder is estimated to be 10 years shorter in comparison with those without this disorder.
C1 [Mujkanovic, Jasmin; Warming, Peder Emil; Kober, Lars Valeur; Winkel, Bo Gregers; Lynge, T. H.; Tfelt-Hansen, Jacob] Rigshosp Hjertecentret, Dept Cardiol, Copenhagen, Hovedstaden, Denmark.
   [Mujkanovic, Jasmin] Univ Copenhagen, Dept Forens Med, Copenhagen, Region Hovedsta, Denmark.
   [Kessing, Lars Vedel] Rigshosp, Dept Psychiat, Copenhagen, Denmark.
   [Tfelt-Hansen, Jacob] Univ Copenhagen, Fac Hlth Sci, Dept Med & Surg, Dept Forens Med, Copenhagen, Region Hovedsta, Denmark.
C3 University of Copenhagen; University of Copenhagen; Copenhagen
   University Hospital; Rigshospitalet; University of Copenhagen
RP Mujkanovic, J (corresponding author), Rigshosp Hjertecentret, Dept Cardiol, Copenhagen, Hovedstaden, Denmark.; Mujkanovic, J (corresponding author), Univ Copenhagen, Dept Forens Med, Copenhagen, Region Hovedsta, Denmark.
EM jasmin.mujkanovic@regionh.dk; peder.emil.warming@regionh.dk;
   Lars.Vedel.Kessing@regionh.dk; lars.kober@regionh.dk;
   bo.winkel@regionh.dk; thomas.hadberg.lynge.02@regionh.dk;
   jacob.tfelt@regionh.dk
RI Tfelt-Hansen, Jacob/AAU-8691-2020; Kessing, Lars/JNS-2493-2023; Winkel,
   Bo/AAZ-9190-2021; Warming, Peder Emil/AFL-9482-2022
OI Kessing, Lars/0000-0001-9377-9436; Tfelt-Hansen,
   Jacob/0000-0003-3895-9316
CR Aktaa S, 2023, EUROPACE, V25, P199, DOI 10.1093/europace/euac114
   Andersen PK, 2017, STAT MED, V36, P3573, DOI 10.1002/sim.7357
   Barcella CA, 2019, RESUSCITATION, V143, P180, DOI 10.1016/j.resuscitation.2019.07.008
   Bjune T, 2018, EUROPACE, V20, P614, DOI 10.1093/europace/euw435
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   Hauck TS, 2020, CAN J PSYCHIAT, V65, P454, DOI 10.1177/0706743720904845
   Ifteni P, 2014, SCHIZOPHR RES, V155, P72, DOI 10.1016/j.schres.2014.03.011
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   Watanabe J, 2017, J CLIN PSYCHOPHARM, V37, P452, DOI 10.1097/JCP.0000000000000724
NR 30
TC 4
Z9 4
U1 2
U2 2
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 1355-6037
EI 1468-201X
J9 HEART
JI Heart
PD DEC
PY 2024
VL 110
IS 23
BP 1365
EP 1371
DI 10.1136/heartjnl-2024-324092
EA OCT 2024
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA Q5W8H
UT WOS:001357945300001
PM 39438152
OA hybrid
DA 2025-06-11
ER

PT J
AU Slopen, N
   Strizich, G
   Hua, SM
   Gallo, LC
   Chae, DH
   Priest, N
   Gurka, MJ
   Bangdiwala, SI
   Bravin, JI
   Chambers, EC
   Daviglus, ML
   Llabre, MM
   Carnethon, MR
   Isasi, CR
AF Slopen, Natalie
   Strizich, Garrett
   Hua, Simin
   Gallo, Linda C.
   Chae, David H.
   Priest, Naomi
   Gurka, Matthew J.
   Bangdiwala, Shrikant, I
   Bravin, Julia, I
   Chambers, Earle C.
   Daviglus, Martha L.
   Llabre, Maria M.
   Carnethon, Mercedes R.
   Isasi, Carmen R.
TI Maternal experiences of ethnic discrimination and child cardiometabolic
   outcomes in the Study of Latino Youth
SO ANNALS OF EPIDEMIOLOGY
LA English
DT Article
DE Study of Latino Youth; Discrimination; Children; Cardiometabolic health
ID C-REACTIVE PROTEIN; CARDIOVASCULAR RISK; MENTAL-HEALTH; RACISM; FAMILY;
   REDUCTION; PARENTS; DISEASE; DESIGN; STROKE
AB Purpose: Limited research has examined maternal experiences of racial/ethnic discrimination in relation to child cardiometabolic health. In this study, we investigated whether maternal experiences of ethnic discrimination were associated with cardiometabolic risk in Hispanic/Latino youth several years later.
   Methods: Our sample included 1146 youth (8-16 years) from the Study of Latino Youth (2012-2014), who were children of the Hispanic Community Health Study/Study of Latinos participants (2008-2011). We used regression models to examine the prospective associations between maternal report of ethnic discrimination in relation to her child's body mass index (BMI) z-score, metabolic syndrome score (MetS), and high sensitivity C-reactive protein (hsCRP) levels 2 years later.
   Results: Maternal ethnic discrimination was associated with youth hsCRP, but not BMI or MetS (P-values >.05). Adjusting for age, nativity, and national background, maternal ethnic discrimination was associated with higher (log) hsCRP levels (beta = 0.18, 95% CI = 0.04 to 0.32) in children. This association was robust to adjustment for maternal and household characteristics (beta = 0.17, 95% CI = 0.04 to 0.31), as well as maternal depression and maternal BMI.
   Conclusions: Maternal ethnic discrimination is associated with inflammation among Hispanic/Latino youth, and not BMI z-score or MetS. Studies are needed to address temporality and pathways. (C) 2019 Elsevier Inc. All rights reserved.
C1 [Slopen, Natalie] Univ Maryland, Dept Epidemiol & Biostat, College Pk, MD 20742 USA.
   [Strizich, Garrett; Hua, Simin; Isasi, Carmen R.] Albert Einstein Coll Med, Dept Epidemiol & Populat Hlth, Bronx, NY 10467 USA.
   [Gallo, Linda C.; Bravin, Julia, I] San Diego State Univ, Dept Psychol, San Diego, CA 92182 USA.
   [Chae, David H.] Auburn Univ, Dept Human Dev & Family Studies, Auburn, AL 36849 USA.
   [Priest, Naomi] Australian Natl Univ, Coll Arts & Social Sci, Ctr Social Res & Methods, Canberra, ACT, Australia.
   [Priest, Naomi] Murdoch Childrens Res Inst, Populat Hlth, Melbourne, Vic, Australia.
   [Gurka, Matthew J.] Univ Florida, Dept Hlth Outcomes & Biomed Informat, Gainesville, FL USA.
   [Bangdiwala, Shrikant, I] McMaster Univ, Dept Hlth Res Methods Evidence & Impact, Hamilton, ON, Canada.
   [Chambers, Earle C.] Dept Family & Social Med, Bronx, NY USA.
   [Daviglus, Martha L.] Univ Illinois, Coll Med, Inst Minor Hlth Res, Chicago, IL USA.
   [Llabre, Maria M.] Univ Miami, Dept Psychol, POB 248185, Coral Gables, FL 33124 USA.
   [Carnethon, Mercedes R.] Northwestern Univ, Dept Prevent Med, Chicago, IL 60611 USA.
C3 University System of Maryland; University of Maryland College Park;
   Yeshiva University; Montefiore Medical Center; Albert Einstein College
   of Medicine; California State University System; San Diego State
   University; Auburn University System; Auburn University; Australian
   National University; Murdoch Children's Research Institute; State
   University System of Florida; University of Florida; McMaster
   University; University of Illinois System; University of Illinois
   Chicago; University of Illinois Chicago Hospital; University of Miami;
   Northwestern University
RP Slopen, N (corresponding author), Univ Maryland, Epidemiol & Biostat, College Pk, MD 20742 USA.
EM nslopen@umd.edu
RI Chae, David/F-6956-2015
OI Slopen, Natalie/0000-0002-5644-6007; Gallo, Linda
   C./0000-0002-3678-5888; Priest, Naomi/0000-0002-2246-0644; Carnethon,
   Mercedes/0000-0001-7035-0848
FU National Heart, Lung, and Blood Institute, United States [R01HL102130];
   National Heart, Lung, and Blood Institute (NHLBI) [N01-HC65233,
   N01-HC65234, N01-HC65235, N01-HC65236, N01-HC65237]; Graduate School,
   University of Maryland, United States; W. K. Kellogg Foundation
   [P3022586]; NHLBI [R01HL120960]
FX The SOL Youth Study was supported by Grant Number R01HL102130 from the
   National Heart, Lung, and Blood Institute, United States. The children
   in SOL Youth are drawn from the study of adults: The Hispanic Community
   Health Study/Study of Latinos, which was supported by contracts from the
   National Heart, Lung, and Blood Institute (NHLBI) to the University of
   North Carolina, United States (N01-HC65233), University of Miami, United
   States (N01-HC65234), Albert Einstein College of Medicine, United States
   (N01-HC65235), Northwestern University, United States (N01-HC65236), and
   San Diego State University, United States (N01-HC65237). N.S. was
   supported by a Research and Scholarship Award from the Graduate School,
   University of Maryland, United States and Grant P3022586 from the W. K.
   Kellogg Foundation. M.J.G. was supported by NHLBI grant R01HL120960.
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NR 43
TC 9
Z9 11
U1 0
U2 6
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1047-2797
EI 1873-2585
J9 ANN EPIDEMIOL
JI Ann. Epidemiol.
PD JUN
PY 2019
VL 34
BP 52
EP 57
DI 10.1016/j.annepidem.2019.03.011
PG 6
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA ID0GS
UT WOS:000471362300010
PM 31060896
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Chrousos, GP
AF Chrousos, GP
TI The role of stress and the hypothalamic-pituitary-adrenal axis in the
   pathogenesis of the metabolic syndrome: neuro-endocrine and target
   tissue-related causes
SO INTERNATIONAL JOURNAL OF OBESITY
LA English
DT Article; Proceedings Paper
CT 8th International Congress on Endocrinology of Obesity Basic, Clinical
   and Therapeutic Aspects
CY SEP, 1998
CL VENICE, ITALY
DE CRH; HPA; glucocorticoids; cortisol; Cushing's syndrome
ID CORTICOTROPIN-RELEASING HORMONE; GLUCOCORTICOID RECEPTOR GENE; BODY-FAT
   DISTRIBUTION; CORTISOL SECRETION; BIOCHEMICAL MANIFESTATIONS;
   CUSHINGS-SYNDROME; PLASMA-CORTISOL; OBESE WOMEN; WEIGHT-LOSS; DEPRESSION
AB The stress system coordinates the adaptive response of the organism to real or perceived stressors. The main components of the stress system are the corticotropin-releasing hormone (CRH) and locus ceruleus-norepinephrine/autonomic (LC/NE) systems and their peripheral effectors, the hypothalamic-pituitary-adrenal (HPA) axis, and the limbs of the autonomic system. Activation of the stress system leads to behavioral and peripheral changes that improve the ability of the organism to adjust homeostasis and increase its chances for survival. Thus, CRH and the LC/NE system stimulate arousal and attention, as well as the mesocorticolimbic dopaminergic system, which is involved in anticipatory and reward phenomena, and the amygdala, which are responsible for the generation of fear. Hypothalamic CRH plays an important role in inhibiting gonadotropin-releasing hormone secretion during stress, while via somatostatin it also inhibits growth hormone, thyrotropin-releasing hormone and thyrotropin secretion, suppressing thus reproduction, growth and thyroid function. Glucocorticoids directly inhibit pituitary gonadotropin, growth hormone and thyrotropin secretion and make the target tissues of sex steroids and growth factors resistant to these substances. In addition, glucocorticoids stimulate hepatic gluconeogenesis, and inhibit or potentiate insulin actions on skeletal muscle and adipose tissue respectively, ultimately promoting visceral adiposity and the metabolic syndrome. Glucocorticoids also have direct effects on the bone, inhibiting osteoblastic activity and causing osteoporosis. Obese subjects with psychiatric manifestations ranging from those of melancholic depression to anxiety with perception of 'uncontrollable' stress, frequently have mild hypercortisolism, while carefully screened obese subjects with no such manifestations are eucortisolemic. The former may have stress-induced glucocorticoid-mediated visceral obesity and metabolic syndrome manifestations, which in the extreme may be called a pseudo-Cushing state that needs to be differentiated from frank Cushing syndrome. Stress-induced hypercortisolism and visceral obesity and their cardiovascular and other sequelae increase the all-cause mortality risk of affected subjects by 2-3-fold and curtail their life expectancy by several years.
C1 Nichhd, Pediat Endocrinol Sect, PREB, NIH, Bethesda, MD 20892 USA.
C3 National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver
   National Institute of Child Health & Human Development (NICHD)
RP Chrousos, GP (corresponding author), Nichhd, Pediat Endocrinol Sect, PREB, NIH, 10 Ctr Dr MSC 1583,Bldg 10,Room 1D42, Bethesda, MD 20892 USA.
RI Chrousos, George/G-8702-2011
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NR 38
TC 462
Z9 544
U1 1
U2 54
PU NATURE PUBLISHING GROUP
PI BASINGSTOKE
PA HOUNDMILLS, BASINGSTOKE RG21 6XS, HAMPSHIRE, ENGLAND
SN 0307-0565
J9 INT J OBESITY
JI Int. J. Obes.
PD JUN
PY 2000
VL 24
SU 2
BP S50
EP S55
DI 10.1038/sj.ijo.0801278
PG 6
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 335NW
UT WOS:000088250400012
PM 10997609
DA 2025-06-11
ER

PT J
AU Cai, YL
   Zhou, SY
   Fan, SH
   Yang, Y
   Tian, KM
   Luo, L
   Deng, RL
   Dai, XY
   Wang, YY
   Zhu, ML
   Liu, T
AF Cai, Yulan
   Zhou, Shiyu
   Fan, Shangheng
   Yang, Yan
   Tian, Kunming
   Luo, Lei
   Deng, Renli
   Dai, Xingyu
   Wang, Yiying
   Zhu, Minglan
   Liu, Tao
TI The multimorbidity association of metabolic syndrome and depression on
   type 2 diabetes: a general population cohort study in Southwest China
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Article
DE type 2 diabetes; metabolic syndrome; depression; complication;
   multimorbidity; cohort study
ID LIFE-STYLE; RISK; MELLITUS; SYMPTOMS; ANTIDEPRESSANTS; INFLAMMATION;
   DIAGNOSIS; ANXIETY; OBESITY; ADULTS
AB Background Metabolic syndrome(MetS) and depression are independently associated with type 2 diabetes (T2DM) risk. However, little is known about the combined effect of MetS and depression on the risk of T2DM. The present study aims to prospectively explore the impact of MetS and depression on T2DM susceptibility among the Chinese general population.Methods 6489 general population without T2DM adults in Southwest China were recruited from 2010 to 2012. Depression and MetS were prospectively assessed using a 9-item Patient Health Questionnaire(PHQ-9) and Guideline for the prevention and treatment of type 2 diabetes mellitus in China (2020 edition) (CDS2020) during 2016-2020, respectively. Modified Poisson regression models were conducted to estimate relative risk(RR) and 95% confidence intervals (95%CI) for independent and combined associations of MetS and depression with an incidence of T2DM.Results During a median follow-up of 6.6 years, 678 cases of T2DM were documented. Individuals with MetS were 1.33 times more likely to develop T2DM than those without MetS. The corresponding RR(95%CI) for depression with no depression was 1.45(1.22-1.72). Notably, compared with no MetS or depression, the multivariate-adjusted RR for a combined effect of MetS and depression on the risk of T2DM was 2.11(1.39-3.22). Moreover, an increased risk of T2DM was more apparent in those >= 60 years, males, and overweight.Conclusions Individuals with multimorbidity of MetS and depression are at a higher risk of T2DM compared with those with no MetS or depression.
C1 [Cai, Yulan; Fan, Shangheng; Yang, Yan] Zunyi Med Univ, Affiliated Hosp 2, Dept Endocrinol & Metab, Zunyi, Guizhou, Peoples R China.
   [Zhou, Shiyu; Deng, Renli; Zhu, Minglan] Zunyi Med Univ, Affiliated Hosp, Dept Nursing, Zunyi, Guizhou, Peoples R China.
   [Tian, Kunming; Luo, Lei] Zunyi Med Univ, Sch Publ Hlth, Dept Prevent Med, Zunyi, Guizhou, Peoples R China.
   [Dai, Xingyu] Zunyi Med Univ, Sch Clin Med, Zunyi, Guizhou, Peoples R China.
   [Wang, Yiying; Liu, Tao] Dept Chron Dis Prevent & Control, Guizhou Dis Prevent & Control, Guiyang, Guizhou, Peoples R China.
C3 Zunyi Medical University; Zunyi Medical University; Zunyi Medical
   University; Zunyi Medical University
RP Zhu, ML (corresponding author), Zunyi Med Univ, Affiliated Hosp, Dept Nursing, Zunyi, Guizhou, Peoples R China.; Liu, T (corresponding author), Dept Chron Dis Prevent & Control, Guizhou Dis Prevent & Control, Guiyang, Guizhou, Peoples R China.
EM lls04561@163.com; liutao9099No_2@163.com
RI Zhou, Shiyu/KRQ-2397-2024
FU National Natural Science Foundation of China10.13039/501100001809
FX We thank all the Guizhou Population Health Cohort Study participants for
   their lasting support and enthusiastic collaboration. We are also
   indebted to all workers for their valuable contributions.
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NR 49
TC 2
Z9 2
U1 2
U2 8
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD JUL 5
PY 2024
VL 15
AR 1399859
DI 10.3389/fendo.2024.1399859
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA YV6B5
UT WOS:001271288400001
PM 39036053
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Maes, M
   Kubera, M
   Obuchowiczwa, E
   Goehler, L
   Brzeszcz, J
AF Maes, Michael
   Kubera, Marta
   Obuchowiczwa, Ewa
   Goehler, Lisa
   Brzeszcz, Joanna
TI Depression's multiple comorbidities explained by (neuro)inflammatory and
   oxidative & nitrosative stress pathways
SO NEUROENDOCRINOLOGY LETTERS
LA English
DT Review
DE depression; cytokines; inflammation; oxidative stress; comorbidity;
   medical illness
ID INFLAMMATORY-BOWEL-DISEASE; SYSTEMIC-LUPUS-ERYTHEMATOSUS; OBSTRUCTIVE
   PULMONARY-DISEASE; ILLNESS RATING-SCALE; CARDIOVASCULAR RISK-FACTORS;
   CHRONIC MEDICAL ILLNESS; ANXIETY-LIKE BEHAVIOR; QUALITY-OF-LIFE;
   PARKINSONS-DISEASE; RHEUMATOID-ARTHRITIS
AB There is now evidence that depression, as characterized by melancholic symptoms, anxiety, and fatigue and somatic (F&S) symptoms, is the clinical expression of peripheral cell-mediated activation, inflammation and induction of oxidative and nitrosative stress (IO&NS) pathways and of central microglial activation, decreased neurogenesis and increased apoptosis. This review gives an explanation for the multiple "co-morbidities" between depression and a large variety of a) brain disorders related to neurodegeneration, e.g. Alzheimer's, Parkinson's and Huntington's disease, multiple sclerosis and stroke; b) medical disorders, such as cardiovascular disorder, chronic fatigue syndrome, chronic obstructive pulmonary disease, rheumatoid arthritis, psoriasis, systemic lupus erythematosus, inflammatory bowel disease, irritable bowel syndrome, leaky gut, diabetes type 1 and 2, obesity and the metabolic syndrome, and HIV infection; and c) conditions, such as hemodialysis, interferon-a-based immunotherapy, the postnatal period and psychosocial stressors. The common denominator of all those disorders/conditions is the presence of microglial activation and/or activation of peripheral IO&NS pathways. There is evidence that shared peripheral and / or central IO&NS pathways underpin the pathophysiology of depression and the previously mentioned disorders and that activation of these IO&NS pathways contributes to shared risk. The IO&NS pathways function as a smoke sensor that detect threats in the peripheral and central parts of the body and signal these threats as melancholic, anxiety, and fatigue and somatic (F&S) symptoms. The presence of concomitant depression is strongly associated with a lower quality of life and increased morbidity and mortality in medical disorders. This may be explained since depression contributes to increased (neuro)inflammatory burden and may therefore drive the inflammatory and degenerative progression. It is concluded that the activation of peripheral and! or central IO&NS pathways may explain the co-occurrence of depression with the above disorders. This shows that depression belongs to the spectrum of inflammatory and degenerative disorders.
C1 [Maes, Michael] Maes Clin TRIA, Bangkok 10310, Thailand.
   [Kubera, Marta] Polish Acad Sci, Inst Pharmacol, Dept Expt Endocrinol, PL-31343 Krakow, Poland.
   [Obuchowiczwa, Ewa] Med Univ Silesia, Dept Pharmacol, PL-40752 Katowice, Poland.
   [Goehler, Lisa] Univ Virginia, Sch Nursing, Ctr Study Complementary & Alternat Therapies, Charlottesville, VA 22904 USA.
   [Brzeszcz, Joanna] Oil & Gas Inst, PL-31503 Krakow, Poland.
C3 Polish Academy of Sciences; Medical University of Silesia; University of
   Virginia; Oil & Gas Institute - National Research Institute
RP Maes, M (corresponding author), Maes Clin TRIA, 998 Rimklongsamsen Rd, Bangkok 10310, Thailand.
RI Maes, Michael/B-8546-2011; Obuchowicz, Ewa/AGM-1556-2022
OI Kubera, Marta/0000-0003-4401-5055; Obuchowicz, Ewa/0000-0002-8684-2377;
   Maes, Michael/0000-0002-2012-871X; Brzeszcz, Joanna/0000-0003-3951-3375
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NR 200
TC 279
Z9 298
U1 1
U2 78
PU MAGHIRA & MAAS PUBLICATIONS
PI MUNSBACH
PA MAGHIRA & MAAS S A R L, 6C, RUE GABRIEL LIPPMANN, L-5365 MUNSBACH,
   LUXEMBOURG
SN 0172-780X
J9 NEUROENDOCRINOL LETT
JI Neuroendocrinol. Lett.
PY 2011
VL 32
IS 1
BP 7
EP 24
PG 18
WC Endocrinology & Metabolism; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology
GA 746TX
UT WOS:000289271700003
PM 21407167
DA 2025-06-11
ER

PT J
AU Melamed, S
   Shirom, A
   Toker, S
   Berliner, S
   Shapira, I
AF Melamed, S
   Shirom, A
   Toker, S
   Berliner, S
   Shapira, I
TI Association of fear of terror with low-grade inflammation among
   apparently healthy employed adults
SO PSYCHOSOMATIC MEDICINE
LA English
DT Article
DE terror; stress; inflammation; depression; C-reactive protein
ID C-REACTIVE PROTEIN; CORONARY-HEART-DISEASE; CARDIOVASCULAR-DISEASE;
   SOCIOECONOMIC-STATUS; METABOLIC SYNDROME; RISK-FACTORS; STRESS;
   INTERLEUKIN-6; MARKERS; CYTOKINES
AB Objective: Based on evidence that psychological stress may induce a chronic inflammatory process, we hypothesized that the stress caused by chronic fear of terror may be associated with low-grade inflammation. This hypothesis was examined in employed men and women with the presence of low-grade inflammation measured by high sensitivity C-reactive protein (CRP). Methods: Apparently healthy employed adults (N = 1153) undergoing periodic health check-ups in a tertiary hospital in Israel completed a questionnaire. Fear of terror (scored 1-5) was assessed by three items measuring the extent to which respondents have deep concern for personal safety, elevated tension in crowded places, and fear of terror strikes causing harm to one's self or one's family members. The main outcome measure was the presence or absence of an elevated CRP level (>3.0 mg/L). Results: Women scored significantly higher on fear of terror compared with men (M = 2.16 vs. M = 1.68, respectively; p < .0001). Most of the study participants who scored high (4 or 5) on fear of terror, reported having experienced this feeling for 1 year or more. In women only, there was a positive association between fear of terror and risk of elevated CRP level (adjusted OR = 1.7, 95% CI 1.2-2.4) in a multivariate model adjusting for generalized anxiety, depressive symptoms, and potentially confounding demographic and biomedical variables. Conclusions: Chronic fear of terror in women, but not in men, is associated with elevated CRP levels, which suggests the presence of low-grade inflammation and a potential risk of cardiovascular disease.
C1 Natl Inst Occupat & Environm Hlth, Dept Occupat Hlth Psychol, IL-43100 Raanana, Israel.
   Tel Aviv Univ, Sackler Fac Med, Tel Aviv Sourasky Med Ctr, Inst Special Med Examiations,MALRAM, IL-69978 Tel Aviv, Israel.
   Tel Aviv Univ, Sackler Fac Med, Dept Med D, IL-69978 Tel Aviv, Israel.
   Tel Aviv Univ, Fac Management, IL-69978 Tel Aviv, Israel.
   Tel Aviv Univ, Sackler Sch Med, IL-69978 Tel Aviv, Israel.
C3 Tel Aviv University; Sackler Faculty of Medicine; Tel Aviv Sourasky
   Medical Center; Tel Aviv University; Sackler Faculty of Medicine; Tel
   Aviv University; Tel Aviv University; Sackler Faculty of Medicine
RP Natl Inst Occupat & Environm Hlth, Dept Occupat Hlth Psychol, POB 3, IL-43100 Raanana, Israel.
EM melameds@ioh.org.il
RI Toker, Sharon/P-5428-2015
OI Toker, Sharon/0000-0001-7621-6607
CR [Anonymous], 1999, DIAGN STAT MAN MENT
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NR 69
TC 43
Z9 49
U1 0
U2 13
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0033-3174
EI 1534-7796
J9 PSYCHOSOM MED
JI Psychosom. Med.
PD JUL-AUG
PY 2004
VL 66
IS 4
BP 484
EP 491
DI 10.1097/01.psy.0000130963.52755.b9
PG 8
WC Psychiatry; Psychology; Psychology, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry; Psychology
GA 840KX
UT WOS:000222858600004
PM 15272092
DA 2025-06-11
ER

PT J
AU Fernández-Abascal, B
   Suárez-Pinilla, M
   Cobo-Corrales, C
   Crespo-Facorro, B
   Suárez-Pinilla, P
AF Fernandez-Abascal, Blanca
   Suarez-Pinilla, Marta
   Cobo-Corrales, Carlos
   Crespo-Facorro, Benedicto
   Suarez-Pinilla, Paula
TI Lifestyle intervention based on exercise and behavioural counselling and
   its effect on physical and psychological health in outpatients with
   schizophrenia spectrum disorders. An exploratory, pragmatic randomized
   clinical trial
SO SCHIZOPHRENIA RESEARCH
LA English
DT Article
DE Schizophrenia; Exercise; Physical activity; Metabolic syndrome; Clinical
   trial; Follow-up studies
ID SELF-DETERMINATION THEORY; INDUCED WEIGHT-GAIN; AEROBIC EXERCISE;
   METABOLIC ABNORMALITIES; BODY-COMPOSITION; SEX-DIFFERENCES;
   BLOOD-PRESSURE; IMPACT; INDIVIDUALS; RISK
AB Patients with Schizophrenia Spectrum Disorders (SSD) often lead unhealthy lifestyles. This pragmatic trial evaluated the effectiveness of a lifestyle intervention, consisting of a 12-week aerobic exercise program and behavioural counselling, in SSD outpatients with metabolic syndrome (MetS). It also aimed to assess persistence of potential effects in a 24-month long-term follow-up. Effectiveness was measured in terms of a wide range of outcomes involving physical and psychological health, quality of life, physical activity and changes in motivation to exercise within the context of the self-determination theory. Our primary outcome was waist circumference change. Thirty-three out of 48 participants completed the study. No differences between groups were found in terms of BMI change or other metabolic parameters. However, the active group (AG) showed improvement regarding waist circumference, negative symptomatology and identified motivation to exercise during the study and follow-up. The AG exhibited changes toward a more active pattern of activity after intervention. Moreover, belonging to the AG was a significant predictor for achieving any degree of clinical improvement after 24-month follow-up. Combined interventions of exercise and behavioural counselling in SSD patients with MetS should be considered as an essential part of the integral treatment in the context of mental health services.
C1 [Fernandez-Abascal, Blanca; Suarez-Pinilla, Paula] Univ Cantabria, Univ Hosp Marques Valdecilla, Dept Psychiat, IDIVAL,Med Sch, Santander 39011, Spain.
   [Cobo-Corrales, Carlos] Univ Cantabria, Sch Educ, Santander 39005, Spain.
   [Crespo-Facorro, Benedicto] Univ Hosp Virgen Rocio IBiS, Sch Med, Dept Psychiat, Seville 41013, Spain.
   [Crespo-Facorro, Benedicto; Suarez-Pinilla, Paula] Inst Salud Carlos III, Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid 28029, Spain.
   [Suarez-Pinilla, Marta] Univ Politecn Madrid UPM, Ctr Biomed Technol, Lab Clin Neurosci, Madrid 28223, Spain.
   [Suarez-Pinilla, Paula] Hosp Univ Marques Valdecilla, Dept Psychiat, Avda Valdecilla S-N, Santander 39008, Spain.
C3 Hospital Universitario Marques de Valdecilla (HUMV); Universidad de
   Cantabria; Universidad de Cantabria; Virgen del Rocio University
   Hospital; Consejo Superior de Investigaciones Cientificas (CSIC);
   University of Sevilla; CSIC-JA-USE - Instituto de Biomedicina de Sevilla
   (IBIS); CIBER - Centro de Investigacion Biomedica en Red; CIBERSAM;
   Instituto de Salud Carlos III; Universidad Politecnica de Madrid;
   Hospital Universitario Marques de Valdecilla (HUMV)
RP Suárez-Pinilla, P (corresponding author), Hosp Univ Marques Valdecilla, Dept Psychiat, Avda Valdecilla S-N, Santander 39008, Spain.
RI Suárez Pinilla, Marta/JHU-6581-2023; Crespo-Facorro,
   BENEDICTO/AAY-2238-2021
OI Crespo-Facorro, Benedicto/0000-0003-0033-7132; Suarez-Pinilla,
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NR 78
TC 1
Z9 1
U1 1
U2 6
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0920-9964
EI 1573-2509
J9 SCHIZOPHR RES
JI Schizophr. Res.
PD NOV
PY 2023
VL 261
BP 256
EP 268
DI 10.1016/j.schres.2023.09.036
EA OCT 2023
PG 13
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA FZ1Z2
UT WOS:001149598200001
PM 37857138
DA 2025-06-11
ER

PT J
AU Guyot, E
   Baudry, J
   Hercberg, S
   Galan, P
   Kesse-Guyot, E
   Péneau, S
AF Guyot, Erika
   Baudry, Julia
   Hercberg, Serge
   Galan, Pilar
   Kesse-Guyot, Emmanuelle
   Peneau, Sandrine
TI Mindfulness Is Associated with the Metabolic Syndrome among Individuals
   with a Depressive Symptomatology
SO NUTRIENTS
LA English
DT Article
DE mindfulness; metabolic syndrome x; risk factors; depression;
   epidemiology
ID DISPOSITIONAL MINDFULNESS; EATING-DISORDERS; HEALTHY WOMEN; LIFE-EVENTS;
   5 FACETS; INTERVENTIONS; RISK; QUESTIONNAIRE; STRESS; NUTRITION
AB The Metabolic Syndrome (MetS) is a major public health burden. Dispositional mindfulness has recently been associated with eating disorders, being overweight, and could therefore be associated with the MetS. We aimed to examine in a cross-sectional design the relationship between mindfulness, the MetS, and its risk factors in a large sample of the adult general population and the influence of depressive symptomatology on this association. Adults participating in the NutriNet-Sante study who had completed the Five Facets Mindfulness Questionnaire and attended a clinical and biological examination were available for inclusion. Multivariable logistic regression models adjusted for socio-demographic and lifestyle factors were performed. A total of 17,490 individuals were included. Among individuals with a depressive symptomatology, those with higher mindfulness were less likely to have a MetS (OR: 0.73, 95% CI: 0.57-0.93), a high waist circumference, a low HDL-cholesterol level and an elevated fasting blood glucose level (all p<0.05). In those without depressive symptomatology, individuals with higher mindfulness were less likely to have a high waist circumference (p<0.01). In conclusion, higher mindfulness was associated with lower odds of developing a MetS only among individuals with a depressive symptomatology.
C1 [Guyot, Erika; Baudry, Julia; Hercberg, Serge; Galan, Pilar; Kesse-Guyot, Emmanuelle; Peneau, Sandrine] Paris 13 Univ, Ctr Res Epidemiol & Stat, Nutr Epidemiol Res Team EREN,COMUE, Sorbonne Paris Cite,INSERM,U1153,Inra,U1125,CNAM, F-93017 Bobigny, France.
   [Hercberg, Serge] Paris 13 Univ, Sorbonne Paris Cite, Surveillance & Nutr Epidemiol Res Unit, Sante Publ France,COMUE, F-93017 Bobigny, France.
   [Hercberg, Serge] Avicenne Hosp, Publ Hlth Dept, F-93017 Bobigny, France.
C3 INRAE; Institut National de la Sante et de la Recherche Medicale
   (Inserm); heSam Universite; Conservatoire National Arts & Metiers
   (CNAM); Universite Paris Cite; Sante publique France; Assistance
   Publique Hopitaux Paris (APHP); Hopital Universitaire Avicenne - APHP
RP Guyot, E (corresponding author), Paris 13 Univ, Ctr Res Epidemiol & Stat, Nutr Epidemiol Res Team EREN,COMUE, Sorbonne Paris Cite,INSERM,U1153,Inra,U1125,CNAM, F-93017 Bobigny, France.
EM e.guyot@eren.smbh.univ-paris13.fr; j.baudry@uren.smbh.univ-paris13.fr;
   s.hercberg@eren.smbh.univ-paris13.fr; p.galan@eren.smbh.univ-paris13.fr;
   e.kesse@eren.smbh.univ-paris13.fr; s.peneau@eren.smbh.univ-paris13.fr
RI Peneau, Sandrine/F-2701-2017; Pilar, Galan/F-2908-2017; Serge,
   Hercberg/F-3038-2017; Guyot, Erika/AAC-1624-2020; Kesse-Guyot,
   Emmanuelle/F-2692-2017; Guyot, Erika/M-7236-2017
OI Kesse-Guyot, Emmanuelle/0000-0002-9715-3534; Guyot,
   Erika/0000-0002-3715-1852
FU French Ministry of Health (DGS); Sante publique France (SpF); French
   National Institute for Health and Medical Research (INSERM); French
   National Institute for Agricultural Research (INRA); National
   Conservatory for Arts and Crafts (CNAM); Medical Research Foundation
   (FRM); University of Paris 13
FX The authors thank Younes Esseddik, Thi Duong Van, Frederic Coffinieres,
   Mac Rakotondrazafy, Regis Gatibelza and Paul Flanzy (computer
   scientists); and Nathalie Arnault, Veronique Gourlet, Fabien Szabo,
   Julien Allegre, Anouar Nechba and Laurent Bourhis
   (data-manager/biostatisticians) for their technical contribution to the
   NutriNet-Sante study. The authors thank all the volunteers of the
   NutriNet-Sante cohort. The NutriNet-Sante Study is supported by the
   French Ministry of Health (DGS), Sante publique France (SpF), the French
   National Institute for Health and Medical Research (INSERM), the French
   National Institute for Agricultural Research (INRA), the National
   Conservatory for Arts and Crafts (CNAM), the Medical Research Foundation
   (FRM) and the University of Paris 13.
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NR 58
TC 3
Z9 3
U1 0
U2 3
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD FEB
PY 2018
VL 10
IS 2
AR 232
DI 10.3390/nu10020232
PG 13
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nutrition & Dietetics
GA FZ4CY
UT WOS:000427540000122
PM 29462979
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Gallegos-Gonzalez, G
   Pineda-García, G
   Serrano-Medina, A
   Martinez, AL
   Ochoa-Ruiz, E
AF Gallegos-Gonzalez, Guadalupe
   Pineda-Garcia, Gisela
   Serrano-Medina, Aracely
   Laura Martinez, Ana
   Ochoa-Ruiz, Estefania
TI Association between Stress and Metabolic Syndrome and its Mediating
   Factors in University Students
SO AMERICAN JOURNAL OF HEALTH BEHAVIOR
LA English
DT Article
DE perceived stress; sleep quality; metabolic syndrome; eating habits;
   university students
ID NIGHT-EATING SYNDROME; SLEEP QUALITY INDEX; PSYCHOMETRIC PROPERTIES;
   PREVALENCE; OBESITY; TIME
AB Objectives: In this study, we evaluated the association between perceived stress and indicators of metabolic syndrome and how this association is mediated by sleep problems, unhealthy eating habits, and night eating syndrome, in addition to serum levels of ghrelin and cortisol in university students. Methods: We recruited 192 students from a public university in Mexico. Weight, height, waist circumference and blood pressure were taken in accordance with standard protocols. Validated questionnaires were used to assess perceived stress, sleep quality and eating habits. Fasting blood samples were taken to measure ghrelin, cortisol, triglycerides, glucose and HDL-C. Results: Path Analysis indicated direct positive effects of stress over PSQI (0 = 0.341) and NES (0 = 0.443); PSQI over NES (0 = 0.233) and NES over glucose (0 = 0.170), triglycerides over LDL-C (0 = 0.215), waist circumference over SBP (0 = 0.259). Likewise, standardized negative regression weights of PSQI over Diet Quality Index (0 =-0.239) and ghrelin concentrations (0 =-0.132), ghrelin over Diet Quality Index (0 =-0.188) and waist circumference (0 =-0.147). Diet Quality Index over triglycerides (0 =-0.184); sleep duration over systolic blood pressure (0 =-0.242); waist circumference over HDL-C (0 =-0.256). Conclusion: Psychological stress leads to increased indicators of MetS via decreased sleep quality, inadequate eating habits and eating behavior in university students.
C1 [Gallegos-Gonzalez, Guadalupe; Pineda-Garcia, Gisela; Serrano-Medina, Aracely; Laura Martinez, Ana; Ochoa-Ruiz, Estefania] Autonomous Univ Baja California, Fa Med & Psychol, Tijuana, BC, Mexico.
C3 Universidad Autonoma de Baja California
RP Ochoa-Ruiz, E (corresponding author), Autonomous Univ Baja California, Fa Med & Psychol, Tijuana, BC, Mexico.
EM estefania.ochoa@uabc.edu.mx
RI Serrano-Medina, Aracely/AAV-2741-2021
FU SEP-PRODEP [511-6/18-8833]
FX SEP-PRODEP, Grant No. 511-6/18-8833 funded this research. The funder had
   no role in the study design, data collection and analysis, decision to
   publish, or preparation of the manuscript. We are grateful to Dr.
   Gilberto Ochoa for providing helpful guidance.
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NR 55
TC 21
Z9 22
U1 2
U2 17
PU PNG PUBLICATIONS
PI OAK RIDGE
PA 2205-K OAK RIDGE RD, #115, OAK RIDGE, NC 27310 USA
SN 1945-7359
J9 AM J HEALTH BEHAV
JI Am. J. Health Behav.
PD NOV
PY 2021
VL 45
IS 6
BP 1091
EP 1102
DI 10.5993/AJHB.45.6.12
PG 12
WC Public, Environmental & Occupational Health
WE Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA YD4BE
UT WOS:000740359100012
PM 34969419
DA 2025-06-11
ER

PT J
AU Marazziti, D
   Rutigliano, G
   Baroni, S
   Landi, P
   Dell'Osso, L
AF Marazziti, Donatella
   Rutigliano, Grazia
   Baroni, Stefano
   Landi, Paola
   Dell'Osso, Liliana
TI Metabolic syndrome and major depression
SO CNS SPECTRUMS
LA English
DT Review
DE Major depression; metabolic syndrome; cardiovascular disease; HPA axis;
   inflammation; leptin; ghrelin
ID MEDITERRANEAN DIETARY PATTERN; AUTONOMIC NERVOUS-SYSTEM; BIPOLAR
   DISORDER; INSULIN-RESISTANCE; WEIGHT-GAIN; MOOD DISORDERS; STRESS
   SYSTEM; HEART-RATE; SYMPTOMS; ASSOCIATION
AB Major depression is associated with a 4-fold increased risk for premature death, largely accounted by cardiovascular disease (CVD). The relationship between depression and CVD is thought to be mediated by the so-called metabolic syndrome (MeS). Epidemiological studies have consistently demonstrated a co-occurrence of depression with MeS components, ie, visceral obesity, dyslipidemia, insulin resistance, and hypertension. Although the exact mechanisms linking MeS to depression are unclear, different hypotheses have been put forward. On the one hand, MeS could be the hallmark of the unhealthy lifestyle habits of depressed patients. On the other, MeS and depression might share common alterations of the stress system, including the hypothalamus-pituitary-adrenal (HPA) axis, the autonomic nervous system, the immune system, and platelet and endothelial function. Both the conditions induce a low grade chronic inflammatory state that, in turn, leads to increased oxidative and nitrosative (O&NS) damage of neurons, pancreatic cells, and endothelium. Recently, neurobiological research revealed that peripheral hormones, such as leptin and ghrelin, which are classically involved in homeostatic energy balance, may play a role in mood regulation. Metabolic risk should be routinely assessed in depressed patients and taken into account in therapeutic decisions. Alternative targets should be considered for innovative antidepressant agents, including cytokines and their receptors, intracellular inflammatory mediators, glucocorticoids receptors, O&NS pathways, and peripheral mediators.
C1 [Marazziti, Donatella; Rutigliano, Grazia; Baroni, Stefano; Landi, Paola; Dell'Osso, Liliana] Univ Pisa, Dipartimento Med Clin & Sperimentale, I-56100 Pisa, Italy.
C3 University of Pisa
RP Marazziti, D (corresponding author), Univ Pisa, Dipartimento Psichiat Neurobiol Farmacol & Biotec, Via Roma 67, I-56100 Pisa, Italy.
EM dmarazzi@psico.med.unipi.i
RI Rutigliano, Grazia/AAO-9072-2020; Baroni, Stefano/AAL-2090-2020
OI Baroni, Stefano/0000-0001-7688-5069; Marazziti,
   Donatella/0000-0002-4021-5829; Rutigliano, Grazia/0000-0001-6014-5357
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NR 108
TC 149
Z9 151
U1 0
U2 42
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
SN 1092-8529
EI 2165-6509
J9 CNS SPECTRUMS
JI CNS Spectr.
PD AUG
PY 2014
VL 19
IS 4
BP 293
EP 304
DI 10.1017/S1092852913000667
PG 12
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA AN9RD
UT WOS:000340944500003
PM 24103843
DA 2025-06-11
ER

PT J
AU Winning, A
   Glymour, MM
   McCormick, MC
   Gilsanz, P
   Kubzansky, LD
AF Winning, Ashley
   Glymour, M. Maria
   McCormick, Marie C.
   Gilsanz, Paola
   Kubzansky, Laura D.
TI Childhood Psychological Distress as a Mediator in the Relationship
   Between Early-Life Social Disadvantage and Adult Cardiometabolic Risk:
   Evidence From the 1958 British Birth Cohort
SO PSYCHOSOMATIC MEDICINE
LA English
DT Article
DE prospective cohort; biomarkers; mediation
ID HEART-DISEASE; CARDIOVASCULAR-DISEASE; ANXIETY DISORDERS; HEALTH;
   ADVERSITY; PATHWAYS; STRESS; INFLAMMATION; OBESITY; PSYCHOPATHOLOGY
AB Objectives: Prior research on the relationship between early adversity and adult chronic disease has often relied on retrospective reports of a limited range of exposures and has not considered childhood psychological distress as a mediator. We investigate whether distress in childhood is one pathway by which early social disadvantage leads to greater cardiometabolic risk in middle adulthood.
   Methods: Data are from the 1958 British Birth Cohort study (sample n = 6027). We created an early social disadvantage index based on 16 exposures related to family and socioeconomic hardship from birth to age 7. Childhood psychological distress was ascertained from internalizing and externalizing symptoms at ages 7, 11, and 16 years. Cardiometabolic risk was assessed with a Z-standardized score derived from 9 immune, cardiovascular, and metabolic biomarkers measured at age 45. We used linear regression models and formal tests of mediation to assess relationships between disadvantage, distress, and subsequent cardiometabolic risk.
   Results: Higher social disadvantage predicted increased adult cardiometabolic risk (beta = 0.05; 95% CI = 0.03-0.07). Mediation analyses revealed a significant direct (path c'; beta = 0.03; 95% CI = 0.01-0.05) and indirect (path ab; beta = 0.02; 95% CI = 0.01-0.02) effect of social disadvantage on cardiometabolic risk, adjusting for potential confounders. Child psychological distress accounted for 37% (95% CI = 34-46%) of the observed association.
   Conclusions: Results suggest childhood distress may be one factor on the pathway linking early disadvantage to higher risk of developing cardiometabolic diseases. Such results may point to the importance of blocking the translation of psychosocial to biological risk during a potentially sensitive developmental window.
C1 [Winning, Ashley; McCormick, Marie C.; Gilsanz, Paola; Kubzansky, Laura D.] Harvard TH Chan Sch Publ Hlth, Dept Social & Behav Sci, Boston, MA USA.
   [Glymour, M. Maria] Univ Calif San Francisco, Sch Med, Dept Epidemiol & Biostat, San Francisco, CA USA.
C3 Harvard University; Harvard T.H. Chan School of Public Health;
   University of California System; University of California San Francisco
RP Winning, A (corresponding author), Econ Mobil Pathways EMPath, Res & Evaluat Dept, 1 Washington Mall,3rd Floor, Boston, MA 02108 USA.
EM awinning@empathways.org
RI Glymour, Maria/AEM-8841-2022
FU Julius B Richmond Fellowship at the Harvard Center on the Developing
   Child; Martha May Eliot Fund at the Harvard School of Public Health
FX Dr Winning was supported by the Julius B Richmond Fellowship at the
   Harvard Center on the Developing Child and by the Martha May Eliot Fund
   at the Harvard School of Public Health. This research received no
   specific grant from any funding agency, commercial, or not-for-profit
   sectors. The authors report no conflicts of interest.
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NR 57
TC 8
Z9 9
U1 0
U2 12
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0033-3174
EI 1534-7796
J9 PSYCHOSOM MED
JI Psychosom. Med.
PD NOV-DEC
PY 2016
VL 78
IS 9
BP 1019
EP 1030
DI 10.1097/PSY.0000000000000409
PG 12
WC Psychiatry; Psychology; Psychology, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry; Psychology
GA EE5LR
UT WOS:000389649600006
PM 27763989
DA 2025-06-11
ER

PT J
AU Gancheva, S
   Galunska, B
   Zhelyazkova-Savova, M
AF Gancheva, Silvia
   Galunska, Bistra
   Zhelyazkova-Savova, Maria
TI Diets rich in saturated fat and fructose induce anxiety and
   depression-like behaviours in the rat: is there a role for lipid
   peroxidation?
SO INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY
LA English
DT Article
DE anxiety-like behaviour; depression-like behaviour; high-fat diet;
   high-fat high-fructose diet; lipid peroxidation; rats
ID OXIDATIVE STRESS; METABOLIC DISTURBANCES; DOWN-REGULATION; INDUCED
   OBESITY; MEMORY; DISORDERS; COGNITION; WESTERN; BRAIN; ASSOCIATION
AB Epidemiological studies reveal associations between obesity/metabolic syndrome and mood disorders. We assessed behavioural changes in rats fed diets enriched in fat and fructose in different proportions and correlated the observed alterations with biochemical changes induced by the diets. Three groups of rats were used as follows: control (C) animals fed regular rat chow, rats fed high-fat diet (HF) and rats fed high-fat and high-fructose diet (HFHF). HF and HFHF animals were also given a 10% fructose solution as drinking water. Behavioural and biochemical parameters were determined. Anxiety was measured by the open-field and the social interaction test. Depression-like behaviour was evaluated by the forced swimming test. The object recognition test was utilized to assess effects on memory. Diet-exposed animals displayed signs of anxiety in the open-field (HF rats had reduced central time; HFHF rats had reduced number of central entries) and in the social interaction test (decreased time of interaction in HF group). In the forced swimming test, the immobility time was prolonged in the HFHF group. While different measures of anxiety scores correlated with visceral adiposity and dyslipidemia, results from both social interaction and forced swimming tests were significantly associated with lipid peroxidation, which in turn also correlated with the metabolic parameters. The experimental diets did not affect the object recognition memory. Both experimental diets induced metabolic derangements in rats and provoked similar anxiety- and depression-like behaviours. Lipid peroxidation seems to play a role in translating diet-induced metabolic alterations into behavioural disorders.
C1 [Gancheva, Silvia; Zhelyazkova-Savova, Maria] Med Univ Varna, Dept Pharmacol & Clin Pharmacol & Therapeut, Varna, Bulgaria.
   [Galunska, Bistra] Med Univ Varna, Dept Biochem Mol Med & Nutrigen, Varna, Bulgaria.
C3 Medical University Varna; Medical University Varna
RP Zhelyazkova-Savova, M (corresponding author), Med Univ Varna, Dept Preclin & Clin Pharmacol, 55 Marin Drinov St, Varna 9002, Bulgaria.
EM mariadz52@yahoo.com
RI Zhelyazkova-Savova, Maria/J-7538-2019; Gancheva, Silvia/ITV-5331-2023
OI Zhelyazkova-Savova, Maria/0000-0003-1132-8813; Gancheva,
   Silvia/0000-0001-5101-7716; Galunska, Bistra/0000-0002-2937-2874
FU Medical University of Varna, Bulgaria
FX The study was funded with personal sources and supported by the Medical
   University of Varna, Bulgaria.
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NR 62
TC 48
Z9 51
U1 0
U2 21
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0959-9673
EI 1365-2613
J9 INT J EXP PATHOL
JI Int. J. Exp. Pathol.
PD OCT
PY 2017
VL 98
IS 5
BP 296
EP 306
DI 10.1111/iep.12254
PG 11
WC Pathology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pathology
GA FR1KW
UT WOS:000418826700006
PM 29210119
OA Green Published
DA 2025-06-11
ER

PT J
AU Tyagi, A
   Cohen, M
   Reece, J
   Telles, S
   Jones, L
AF Tyagi, Anupama
   Cohen, Marc
   Reece, John
   Telles, Shirely
   Jones, Linda
TI Heart Rate Variability, Flow, Mood and Mental Stress During Yoga
   Practices in Yoga Practitioners, Non-yoga Practitioners and People with
   Metabolic Syndrome
SO APPLIED PSYCHOPHYSIOLOGY AND BIOFEEDBACK
LA English
DT Article
DE Meditation; Pranayama; Reactivity and recovery; Autonomic flexibility;
   Mood and flow experience
ID AUTONOMIC NERVOUS-SYSTEM; BLOOD-PRESSURE REACTIONS; CARDIOVASCULAR RISK;
   FOLLOW-UP; INSULIN-RESISTANCE; VAGAL TONE; MEDITATION; REACTIVITY;
   RESPONSES; DISEASE
AB Heart Rate Variability (HRV) and respiratory sinus arrhythmia are directly associated with autonomic flexibility, self-regulation and well-being, and inversely associated with physiological stress, psychological stress and pathology. Yoga enhances autonomic activity, mitigates stress and benefits stress-related clinical conditions, yet the relationship between autonomic activity and psychophysiological responses during yoga practices and stressful stimuli has not been widely explored. This experimental study explored the relationship between HRV, mood states and flow experiences in regular yoga practitioners (YP), non-yoga practitioners (NY) and people with metabolic syndrome (MetS), during Mental Arithmetic Stress Test (MAST) and various yoga practices. The study found that the MAST placed a cardio-autonomic burden in all participants with the YP group showing the greatest reactivity and the most rapid recovery, while the MetS group had significantly blunted recovery. The YP group also reported a heightened experience of flow and positive mood states compared to NY and MetS groups as well as having a higher vagal tone during all resting conditions. These results suggest yoga practitioners have a greater homeostatic capacity and autonomic, metabolic and physiological resilience. Further studies are now needed to determine if regular yoga practice may improve autonomic flexibility in non-yoga practitioners and metabolic syndrome patients.
   Clinical Trial No 'ACTRN 2614001075673'.
C1 [Tyagi, Anupama; Cohen, Marc; Jones, Linda] RMIT Univ, Sch Hlth Sci, Bundoora, Vic 3083, Australia.
   [Reece, John] Australian Coll Appl Psychol, Melbourne, Vic 3000, Australia.
   [Telles, Shirely] Patanjali Res Fdn, Haridwar 249402, Uttrakhand, India.
C3 Royal Melbourne Institute of Technology (RMIT); Australian College of
   Applied Psychology
RP Cohen, M (corresponding author), RMIT Univ, Sch Hlth Sci, Bundoora, Vic 3083, Australia.
EM marc.cohen@rmit.edu.au
RI Telles, Shirley/U-7154-2019; Jones, Linda/GXG-2821-2022; Cohen,
   Marc/GWV-0933-2022
OI Jones, Linda K/0000-0002-2116-8545; Cohen, Marc/0000-0002-5876-6565;
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NR 62
TC 24
Z9 29
U1 2
U2 14
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1090-0586
EI 1573-3270
J9 APPL PSYCHOPHYS BIOF
JI Appl. Psychophysiol. Biofeedback
PD DEC
PY 2016
VL 41
IS 4
BP 381
EP 393
DI 10.1007/s10484-016-9340-2
PG 13
WC Psychology, Clinical
WE Social Science Citation Index (SSCI)
SC Psychology
GA ED6MR
UT WOS:000388970200003
PM 27457341
DA 2025-06-11
ER

PT J
AU Liang, YJ
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   Chen, XH
   Lin, CL
AF Liang, Yinji
   Zou, Lili
   Tian, Yaling
   Zhou, Shuang
   Chen, Xinhe
   Lin, Chenli
TI Dietary and metabolic risk of neuropsychiatric disorders: insights from
   animal models
SO BRITISH JOURNAL OF NUTRITION
LA English
DT Article
DE Diet; Neuropsychiatric disorders; Depression; Metabolic risk; Animal
   model
ID HIGH-FAT-DIET; DEPRESSIVE-LIKE BEHAVIOR; ANXIETY-LIKE BEHAVIOR; 5-HT3
   RECEPTOR ANTAGONIST; TYPE-2 DIABETES-MELLITUS; TLR4 UP-REGULATION;
   INDUCED-OBESITY; OXIDATIVE STRESS; GUT MICROBIOTA; LIVER-DISEASE
AB Neuropsychiatric disorders are major causes of the global burden of diseases, frequently co-occurring with multiple co-morbidities, especially obesity, type 2 diabetes mellitus, non-alcoholic fatty liver disease and its various risk factors in the metabolic syndrome. While the determining factors of neuropsychiatric disorders are complex, recent studies have shown that there is a strong link between diet, metabolic state and neuropsychiatric disorders, including anxiety and depression. There is no doubt that rodent models are of great value for preclinical research. Therefore, this article focuses on a rodent model of chronic consumption of high-fat diet (HFD), and/or the addition of a certain amount of cholesterol or sugar, meanwhile, summarising the pattern of diet that induces anxiety/depressive-like behaviour and the underlying mechanism. We highlight how dietary and metabolic risk influence neuropsychiatric behaviour in animals. Changes in dietary patterns, especially HFD, can induce anxiety- or depression-like behaviours, which may vary by diet exposure period, sex, age, species and genetic background of the animals used. Furthermore, dietary patterns significantly aggravate anxiety/depression-like behaviour in animal models of neuropsychiatric disorders. The mechanisms by which diet induces anxiety/depressive-like behaviour may involve neuroinflammation, neurotransmitters/neuromodulators, neurotrophins and the gut-brain axis. Future research should be focused on elucidating the mechanism and identifying the contribution of diet and diet-induced metabolic risk to neuropsychiatric disorders, which can form the basis for future clinical dietary intervention strategies for neuropsychiatric disorders.
C1 [Liang, Yinji; Zhou, Shuang] Jinan Univ, Sch Nursing, 601 Huangpu Ave West, Guangzhou 510632, Guangdong, Peoples R China.
   [Zou, Lili; Tian, Yaling; Lin, Chenli] Jinan Univ, Sch Med, 601 Huangpu Ave West, Guangzhou 510632, Guangdong, Peoples R China.
   [Chen, Xinhe] Jinan Univ, Sch Stomatol, 601 Huangpu Ave West, Guangzhou 510632, Guangdong, Peoples R China.
C3 Jinan University; Jinan University; Jinan University
RP Lin, CL (corresponding author), Jinan Univ, Sch Med, 601 Huangpu Ave West, Guangzhou 510632, Guangdong, Peoples R China.
EM igene@foxmail.com
RI Zou, Lili/ABC-2888-2021; liang, yinji/AGV-5846-2022; Lin,
   Chen-Li/AAT-9605-2021; Chen, Xinhe/KKL-9119-2024; Tian,
   Jia-yue/HNJ-1853-2023
FU Traditional Chinese Medicine Bureau of Guangdong in China [20161065,
   20201075]; National Health and Family Planning Commission of Guangdong
   in China [A2016583, A2017228, A2017140, A2020137, A2021374]; Natural
   Science Foundation of Guangdong in China [2016A030313824]; Undergraduate
   Training Programs for Innovation and Entrepreneurship of Jinan
   University in China [CX20157, CX20145]; 'Challenge Cup' Undergraduate
   Academic Science and Technology Curriculum of Jinan University in China
   [19113028]; 22nd Batch of Teaching Reform Research Projects of Jinan
   University [JG2020080]; Teaching Quality and Teaching Reform Project of
   Undergraduate University of Guangdong in China (2017); Teaching Quality
   and Teaching Reform Project of Undergraduate University of Guangdong in
   China (2020)
FX This work was supported in part by the Traditional Chinese Medicine
   Bureau of Guangdong in China (no. 20161065 and 20201075), the National
   Health and Family Planning Commission of Guangdong in China (no.
   A2016583, A2017228, A2017140, A2020137 and A2021374), the Natural
   Science Foundation of Guangdong in China (no. 2016A030313824), the
   Undergraduate Training Programs for Innovation and Entrepreneurship of
   Jinan University in China (no. CX20157 and CX20145), the `Challenge Cup'
   Undergraduate Academic Science and Technology Curriculum of Jinan
   University in China (no. 19113028), the 22nd Batch of Teaching Reform
   Research Projects of Jinan University (JG2020080) and Teaching Quality
   and Teaching Reform Project of Undergraduate University of Guangdong in
   China (2017 and 2020).
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NR 133
TC 12
Z9 14
U1 3
U2 34
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1145
EI 1475-2662
J9 BRIT J NUTR
JI Br. J. Nutr.
PD DEC 28
PY 2021
VL 126
IS 12
BP 1771
EP 1787
AR PII S0007114521000659
DI 10.1017/S0007114521000659
PG 17
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nutrition & Dietetics
GA WX0TV
UT WOS:000718318500004
PM 33618780
DA 2025-06-11
ER

PT J
AU Sato, AF
   Fahrenkamp, AJ
AF Sato, Amy F.
   Fahrenkamp, Amy J.
TI From Bench to Bedside Understanding Stress-Obesity Research Within the
   Context of Translation to Improve Pediatric Behavioral Weight Management
SO PEDIATRIC CLINICS OF NORTH AMERICA
LA English
DT Article
DE Obesity; Stress; Weight management; Adolescents; Translational research;
   Mindfulness
ID MINDFULNESS-BASED INTERVENTION; BODY-MASS INDEX; EATING BEHAVIOR;
   PHYSICAL-ACTIVITY; PSYCHOLOGICAL STRESS; CORTISOL REACTIVITY; OVERWEIGHT
   CHILDREN; METABOLIC SYNDROME; DIETARY RESTRAINT; PERCEIVED STRESS
AB A growing body of literature suggests that stress, including chronic stress and acute physiologic stress reactivity, is one contributor to the development and maintenance of obesity in youth. Little has been done to apply the literature on stress and obesity risk to inform the development of pediatric behavioral weight control (BWC) interventions. The aims of this review are to (1) discuss research linking stress and pediatric obesity, (2) provide examples of the implications of the stress-obesity research for pediatric BWC development, and (3) propose that a mindfulness-based approach may be useful in targeting stress reduction within pediatric BWC.
C1 [Sato, Amy F.; Fahrenkamp, Amy J.] Kent State Univ, Dept Psychol Sci, 600 Hilltop Dr, Kent, OH 44242 USA.
C3 University System of Ohio; Kent State University; Kent State University
   Salem; Kent State University Kent
RP Sato, AF (corresponding author), Kent State Univ, Dept Psychol Sci, 600 Hilltop Dr, Kent, OH 44242 USA.
EM asato2@kent.edu
RI Sato, Amy/K-7916-2018
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NR 95
TC 4
Z9 5
U1 2
U2 15
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0031-3955
EI 1557-8240
J9 PEDIATR CLIN N AM
JI Pediatr. Clin. N. Am.
PD JUN
PY 2016
VL 63
IS 3
BP 401
EP +
DI 10.1016/j.pcl.2016.02.003
PG 24
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Pediatrics
GA DP9OB
UT WOS:000378824600005
PM 27261542
DA 2025-06-11
ER

PT J
AU Fibbins, H
   Ward, PB
   Watkins, A
   Curtis, J
   Rosenbaum, S
AF Fibbins, Hamish
   Ward, Philip B.
   Watkins, Andrew
   Curtis, Jackie
   Rosenbaum, Simon
TI Improving the health of mental health staff through exercise
   interventions: a systematic review
SO JOURNAL OF MENTAL HEALTH
LA English
DT Review
DE Exercise; mental illness; psychiatry; systematic review; inpatient;
   staff
ID PHYSICAL HEALTH; LIFE-STYLE; CARDIOVASCULAR-DISEASE; SMOKING-CESSATION;
   PEOPLE; ILLNESS; METAANALYSIS; MORTALITY; SCHIZOPHRENIA; DISORDERS
AB Background: Exercise interventions are efficacious in reducing cardiometabolic risk and improving symptoms in people with severe mental illness, yet evidence guiding the implementation and scalability of such efforts is lacking. Given increasing efforts to address the disparity in physical health outcomes facing people with a mental illness, novel approaches to increasing adoption of effective interventions are required. Exercise interventions targeting mental health staff may improve staff health while also creating more positive attitudes towards the role of lifestyle interventions for people experiencing mental illness.Aims: We aimed to determine the feasibility, acceptability and effectiveness of exercise interventions delivered to staff working in mental health services.Method: A systematic review was conducted from database inception, until November 2017. Studies recruiting staff participants to receive an exercise intervention were eligible for inclusion.Results: Five studies met the inclusion criteria. Physical health interventions for mental health staff were feasible and acceptable with low dropout rates. Reductions in anthropometric measures and work-related stress were reported.Conclusions: Limited evidence suggests that exercise interventions targeting mental health staff are feasible and acceptable. Further research is required to determine the efficacy of such interventions and the impact such strategies may have on staff culture and patient outcomes.
C1 [Fibbins, Hamish; Watkins, Andrew; Curtis, Jackie] South Eastern Sydney Local Hlth Dist, Keeping Body Mind Program, Sydney, NSW, Australia.
   [Fibbins, Hamish; Ward, Philip B.; Curtis, Jackie; Rosenbaum, Simon] Univ New South Wales, Sch Psychiat, Sydney, NSW, Australia.
   [Ward, Philip B.] South Western Sydney Local Hlth Dist, Schizophrenia Res Unit, Sydney, NSW, Australia.
   [Ward, Philip B.] Ingham Inst Appl Med Res, Liverpool, NSW, Australia.
   [Watkins, Andrew] Univ Technol, Fac Hlth, Sydney, NSW, Australia.
   [Rosenbaum, Simon] Black Dog Inst, Randwick, NSW, Australia.
C3 South Eastern Sydney Local Health District; University of New South
   Wales Sydney; South Western Sydney Local Health District; Ingham
   Institute for Applied Medical Research; University of Technology Sydney;
   Black Dog Institute
RP Fibbins, H (corresponding author), Univ New South Wales, Sydney, NSW, Australia.
EM hamish.fibbins@health.nsw.gov.au
RI Curtis, Jackie/J-5789-2019; Fibbins, Hamish/KLZ-4932-2024; Rosenbaum,
   Simon/Y-3241-2019; Ward, Philip/JCE-6293-2023
OI Rosenbaum, Simon/0000-0002-8984-4941; Watkins,
   Andrew/0000-0003-3452-8682; Ward, Philip/0000-0002-5779-7722; Fibbins,
   Hamish/0000-0002-2673-7866; Curtis, Jackie/0000-0001-6884-0098
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NR 47
TC 24
Z9 26
U1 1
U2 51
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 0963-8237
EI 1360-0567
J9 J MENT HEALTH
JI J. Ment. Heal.
PY 2018
VL 27
IS 2
BP 184
EP 191
DI 10.1080/09638237.2018.1437614
PG 8
WC Psychology, Clinical; Psychiatry
WE Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA FX5GT
UT WOS:000426106800013
PM 29447044
DA 2025-06-11
ER

PT J
AU Liu, JZ
   Yang, YL
   Zhang, YJ
   Wang, HF
   Wei, WJ
   Lang, XE
   Zhang, XY
AF Liu, Jizhou
   Yang, Yonglan
   Zhang, Yanjiang
   Wang, Haifeng
   Wei, Wenjian
   Lang, Xiaoe
   Zhang, Xiangyang
TI Prevalence and risk factors of anxiety symptoms in first-episode and
   drug-naïve major depressive disorder patients with metabolic syndrome
SO EUROPEAN JOURNAL OF PSYCHIATRY
LA English
DT Article
DE Anxiety symptoms; Major depressive disorder; First episode and drug
   naive (FEDN); Metabolic syndrome; Risk factor
ID ANXIOUS DEPRESSION; COMORBID ANXIETY; METAANALYSIS; HYPERTENSION;
   ASSOCIATION; CHINA
AB Background and objectives: Patients with major depressive disorder (MDD) have high comorbidity with metabolic syndrome (MetS), although anxiety is prevalent comorbidity in MDD patients. However, there is no study on anxiety symptoms (AS) in MDD patients with MetS. Therefore, we aimed to identify the prevalence and risk factors of AS in patients with MetS who experienced a first-episode and drug naive (FEDN) of MDD. Methods: In this cross-sectional study, 1718 FEDN of MDD outpatients with MetS were included. Sociodemographic data, clinical characteristics, suicidal attempts, and physical and biochemical parameters were collected. Hamilton Anxiety Rating Scale (HAMA), Hamilton Depression Rating Scale (HAMD), and Positive and Negative Syndrome Scale (PANSS) positive subscale were performed to detect the AS. Multiple linear regression analysis was used to analyze the correlation. Results: The prevalence of AS in MDD patients with MetS was 85.96%, which was 1.79 times greater than that in patients with MDD alone (P<0.05). MDD patients with MetS had a greater rate of attempted suicide, a higher HAMD total score, and a higher diastolic blood pressure than MDD patients without AS (P<0.05). Their combination could distinguish AS in MDD patients. Moreover, HAMD score, thyroid-stimulating hormone (TSH) levels, PANSS positive score, and suicide attempts were related to HAMA scores in MDD patients with comorbid MetS (P<0.05). Conclusion: There is a significant frequency of AS in MDD patients with MetS. Multiple clinical indicators and metabolic markers are associated with AS in patients with MDD and MetS. (c) 2023 The Authors. Published by Elsevier Espana, S.L.U. on behalf of Sociedad Espanola de Psiquiatria y Salud Mental.
C1 [Liu, Jizhou; Yang, Yonglan; Zhang, Yanjiang; Wang, Haifeng; Wei, Wenjian] 2nd Peoples Hosp Honghe Hani & Yi Autonomous Prefe, Dept Clin Psychol, Jianshui 654399, Peoples R China.
   [Lang, Xiaoe] Shanxi Med Univ, Hosp 1, Dept Psychiat, Clin Med Coll 1, Taiyuan 030000, Peoples R China.
   [Zhang, Xiangyang] Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing 100101, Peoples R China.
   [Zhang, Xiangyang] Univ Chinese Acad Sci, Dept Psychol, Beijing 100101, Peoples R China.
   [Zhang, Xiangyang] Chinese Acad Sci, Inst Psychol, 16 Lincui Rd, Beijing 100101, Peoples R China.
C3 Shanxi Medical University; Chinese Academy of Sciences; Institute of
   Psychology, CAS; Chinese Academy of Sciences; University of Chinese
   Academy of Sciences, CAS; Chinese Academy of Sciences; Institute of
   Psychology, CAS
RP Zhang, XY (corresponding author), Chinese Acad Sci, Inst Psychol, 16 Lincui Rd, Beijing 100101, Peoples R China.
EM zhangxyxyx@sina.com
RI Zhang, Xiangyang/ABC-7380-2022; Sun, Yue/KHU-8159-2024; han,
   Yuyan/JPL-8939-2023; WANG, QIANWEN/KVY-5475-2024
OI Zhang, Xiangyang/0000-0003-3326-382X
FU Chinese National Programs for Brain Science and Brain-like Intelligence
   Technology [2021ZD0202102]
FX <B>Funding</B> This work was supported by the Chinese National Programs
   for Brain Science and Brain-like Intelligence Technology (2021ZD0202102
   to XYZ) .
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NR 41
TC 1
Z9 1
U1 1
U2 2
PU ELSEVIER ESPANA SLU
PI BARCELONA
PA AV JOSEP TARRADELLAS, 20-30, 1ERA PLANTA, BARCELONA, CP-08029, SPAIN
SN 0213-6163
J9 EUR J PSYCHIAT
JI Eur. J. Psychiat.
PD OCT-DEC
PY 2023
VL 37
IS 4
AR 100217
DI 10.1016/j.ejpsy.2023.07.001
EA OCT 2023
PG 7
WC Psychiatry
WE Social Science Citation Index (SSCI)
SC Psychiatry
GA IF8G1
UT WOS:001164999700001
OA hybrid
DA 2025-06-11
ER

PT J
AU Bergmann, N
   Gyntelberg, F
   Faber, J
AF Bergmann, N.
   Gyntelberg, F.
   Faber, J.
TI The appraisal of chronic stress and the development of the metabolic
   syndrome: a systematic review of prospective cohort studies
SO ENDOCRINE CONNECTIONS
LA English
DT Review
DE metabolic syndrome; adiposity; hypertension; dyslipidemia; type 2
   diabetes mellitus; psychological stress; job stress
ID AMBULATORY BLOOD-PRESSURE; EFFORT-REWARD IMBALANCE; BODY-MASS INDEX;
   PSYCHOSOCIAL WORK FACTORS; JOB STRAIN; RISK-FACTORS; WEIGHT-GAIN;
   PSYCHOLOGICAL DISTRESS; CARDIOVASCULAR RISK; MARITAL ADJUSTMENT
AB Chronic psychosocial stress has been proposed as a risk factor for the development of the metabolic syndrome (MES). This review gives a systematic overview of prospective cohort studies investigating chronic psychosocial stress as a risk factor for incident MES and the individual elements of MES. Thirty-nine studies were included. An association between chronic psychosocial stress and the development of MES was generally supported. Regarding the four elements of MES: i) weight gain: the prospective studies supported etiological roles for relationship stress, perceived stress, and distress, while the studies on work-related stress (WS) showed conflicting results; ii) dyslipidemi: too few studies on psychosocial stress as a risk factor for dyslipidemia were available to draw a conclusion; however, a trend toward a positive association was present; iii) type 2 diabetes mellitus (DM2): prospective studies supported perceived stress and distress as risk factors for the development of DM2 among men, but not among women, while WS was generally not supported as a risk factor among neither men nor women; iv) hypertension: marital stress and perceived stress might have an influence on blood pressure (BP), while no association was found regarding distress. Evaluating WS the results were equivocal and indicated that different types of WS affected the BP differently between men and women. In conclusion, a longitudinal association between chronic psychosocial stress and the development of MES seems present. However, the number of studies with sufficient quality is limited and the design of the studies is substantially heterogeneous.
C1 [Bergmann, N.; Faber, J.] Herlev Univ Hosp, Dept Med O, Endocrine Unit, DK-2730 Herlev, Denmark.
   [Gyntelberg, F.] Natl Res Ctr Working Environm, Copenhagen, Denmark.
   [Faber, J.] Univ Copenhagen, Fac Hlth Sci, Copenhagen, Denmark.
C3 University of Copenhagen; Herlev & Gentofte Hospital; National Research
   Centre for the Working Environment; University of Copenhagen
RP Bergmann, N (corresponding author), Herlev Univ Hosp, Dept Med O, Endocrine Unit, DK-2730 Herlev, Denmark.
EM n.c.bergmann@hotmail.com
OI Bergmann, Natasha Chidekel/0000-0002-6797-8041
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NR 81
TC 154
Z9 170
U1 0
U2 24
PU BIOSCIENTIFICA LTD
PI BRISTOL
PA STARLING HOUSE, 1600 BRISTOL PARKWAY N, BRISTOL, ENGLAND
EI 2049-3614
J9 ENDOCR CONNECT
JI Endocr. Connect.
PD JUN 1
PY 2014
VL 3
IS 2
BP R55
EP R80
DI 10.1530/EC-14-0031
PG 26
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA V44UM
UT WOS:000209773900003
PM 24743684
OA Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Moon, WH
   Kwon, M
   Kim, SA
AF Moon, Weon-Hee
   Kwon, Myoungjin
   Kim, Sun Ae
TI Examining the health-related quality of life of middle-aged men with
   metabolic syndrome based on their stress level
SO JOURNAL OF MENS HEALTH
LA English
DT Article
DE quality of life; middle aged; men; metabolic syndrome; stress; mental
   health
ID PREVALENCE; COMMUNITY; SUPPORT; ADULTS
AB Background: This study was conducted to identify the factors that affect the health-related quality of life (HRQoL) of middle-aged men with metabolic syndrome (MetS) based on their stress level using data from the Korea National Health and Nutrition Examination Survey (KNHANES). Methods: The participants of this study were men aged between 40-64 with MetS who were included in the KNHANES. The main variables of this study were HRQoL, which was measured using the EuroQol-5 Dimension (EQ-5D); general characteristics, health-related characteristics, and dietary behaviors. Results: The subjective health of the group with less stress was significantly better. Compared to the unhealthy group, the groups perceived as healthy and normal had a higher HRQoL. The economic level, suicidal ideation, and dinner arrangement (presence of family) of the stressed group were significantly associated with their HRQoL. Compared to a low economic level, the high and middle economic levels were more associated with the subjects' BRQoL. Compared to the group without suicidal ideation, the group that experienced suicidal association had a lower HRQoL. Compared to the group that did not dine with their family, the group that dined with family had a higher HRQoL. Conclusions: The results of this study expand the scientific understanding of HRQol., based on stress among middle-aged men with metabolic syndrome. Since differences in the influence of the factors that affect HRQoL were identified based on the level of stress experienced, the stress level of middle-aged men should be considered when devising an intervention strategy to improve their HRQoL.
C1 [Moon, Weon-Hee] Pai Chai Univ, Dept Nursing Sci, Daejeon 35345, South Korea.
   [Kwon, Myoungjin] Daejeon Univ, Dept Nursing, Daejeon 34520, South Korea.
   [Kim, Sun Ae] Korea Natl Univ Transportat, Dept Nursing, Chungbuk 27909, South Korea.
C3 Pai Chai University; Daejeon University; Korea National University of
   Transportation
RP Kwon, M (corresponding author), Daejeon Univ, Dept Nursing, Daejeon 34520, South Korea.; Kim, SA (corresponding author), Korea Natl Univ Transportat, Dept Nursing, Chungbuk 27909, South Korea.
EM mjkwon@dju.kr; sakim@ut.ac.kr
RI Kim, Sun/G-3451-2013; Kwon, Myoungjin/AAG-1779-2020
FU Pai Chai University
FX This research was partially supported by the Pai Chai University
   research grant in 2020.
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NR 43
TC 0
Z9 0
U1 0
U2 2
PU MRE PRESS
PI SINGAPORE
PA 14 ROBINSON RD #08-01A FAR EAST FINANCE, SINGAPORE, SINGAPORE
SN 1875-6867
EI 1875-6859
J9 J MENS HEALTH
JI J. Mens Health
PD APR
PY 2022
VL 18
IS 4
AR 96
DI 10.31083/j.jomh1804096
PG 9
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA 1N1CP
UT WOS:000800400400014
OA gold
DA 2025-06-11
ER

PT J
AU van Dijk, G
   Buwalda, B
AF van Dijk, Gertjan
   Buwalda, Bauke
TI Neurobiology of the metabolic syndrome: An allostatic perspective
SO EUROPEAN JOURNAL OF PHARMACOLOGY
LA English
DT Article; Proceedings Paper
CT Spring Meeting of the European Journal of Pharmacology
CY SEP 14-16, 2007
CL NETHERLANDS
DE psychosocial stress; obesity; energy balance; human; (Rat)
ID MESSENGER-RNA EXPRESSION; STRESS-INDUCED ANOREXIA; PITUITARY-ADRENAL
   AXIS; DIET-INDUCED OBESITY; FOOD-INTAKE; ENERGY-BALANCE; SOCIAL STRESS;
   BODY-WEIGHT; DIABETES-MELLITUS; ANXIETY DISORDERS
AB The metabolic syndrome is a cluster of more or less related metabolic and cardiovascular derangements including visceral obesity, insulin resistance, blood and tissue dislipidemia, high blood pressure and it is often associated with neuroendocrine and immunological dysregulations. The aetiology of this syndrome is clinically highly relevant because it predisposes to life-threatening complications, such as Diabetes Mellitus, kidney failure, cardiovascular disease, and certain types of cancer. Contributing factors include a sedentary life-style combined with increased dietary fat intake and psychosocial stress. From a biological viewpoint, however, the metabolic syndrome can be considered as a maladaptive consequence of an initially successful adaptation to high environmental demands. As opposed to pre-historic times - when environmental demands were usually energy-costly (e.g., fight/flight/hunt) and nutritional resource often inadequate - energy-utilizing actions serve no longer an optimal solution to deal with environmental demands of current human society. This paper describes the interactions between psychosocial stress and nutrition and how these may affect emotional and metabolic components of the metabolic syndrome. A deeper understanding of these interactions is necessary to come to effective treatment and prevention of the metabolic syndrome in the future. (C) 2008 Elsevier B.V. All rights reserved.
C1 [van Dijk, Gertjan] Univ Groningen, Unit Neuroendocrinol, Ctr Behav & Neurosci, Ctr Biol, NL-9751 NN Haren, Netherlands.
C3 University of Groningen
RP van Dijk, G (corresponding author), Univ Groningen, Unit Neuroendocrinol, Ctr Behav & Neurosci, Ctr Biol, Kerklaan 30, NL-9751 NN Haren, Netherlands.
EM gertjan.van.dijk@rug.nl
RI Buwalda, Bauke/L-1427-2013
OI van Dijk, Gertjan/0000-0002-6565-4019
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NR 104
TC 26
Z9 29
U1 0
U2 8
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0014-2999
EI 1879-0712
J9 EUR J PHARMACOL
JI Eur. J. Pharmacol.
PD MAY 6
PY 2008
VL 585
IS 1
BP 137
EP 146
DI 10.1016/j.ejphar.2007.11.079
PG 10
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Pharmacology & Pharmacy
GA 305AD
UT WOS:000256149300016
PM 18395710
OA Green Published
DA 2025-06-11
ER

PT J
AU Arabi, A
   Nasrallah, D
   Mohsen, S
   Abugharbieh, L
   Al-Hashimi, D
   Almass, S
   Albasti, S
   Al-Ajmi, SA
   Khan, MN
   Zughaier, SM
AF Arabi, Ahmed
   Nasrallah, Dima
   Mohsen, Sara
   Abugharbieh, Lana
   Al-Hashimi, Dana
   Almass, Shaikha
   Albasti, Shahd
   Al-Ajmi, Saeed A.
   Khan, Muhammad Naseem
   Zughaier, Susu M.
TI Association between Serum Vitamin D Status and Circadian Syndrome: A
   Cross-Sectional Study
SO NUTRIENTS
LA English
DT Article
DE Vitamin D; Circadian Syndrome (CircS); Metabolic Syndrome (MetS); Type 2
   diabetes; NHANES
ID D DEFICIENCY; DEPRESSION; CELLS
AB Background: Circadian Syndrome (CircS) encompasses cardiometabolic risk factors and comorbidities, indicating an elevated susceptibility to cardiovascular disease and type 2 diabetes. Methods: This cross-sectional study aimed to investigate the association between vitamin D levels and each of the following: CircS, metabolic syndrome (MetS), and the individual components of CircS. Data from 14,907 adults who participated in the National Health and Nutrition Examination Survey (NHANES) between 2007 and 2018 were utilized. CircS was defined based on MetS components, alongside depression, short sleep, and non-alcoholic fatty liver disease (NAFLD). Results: Our results indicated that low vitamin D levels exhibited meaningful associations with CircS, with vitamin D deficiency and inadequacy demonstrating 2.21-fold (95% CI 1.78-2.74, p < 0.001) and 1.33-fold (95% CI 1.14-1.54, p < 0.001) increases in CircS odds, respectively. The association between vitamin D deficiency and CircS was stronger than that with MetS. Additionally, a dose-response gradient in odds of CircS components, particularly with short sleep duration, was noted as serum vitamin D levels decreased. Conclusions: our findings highlight a significant association between low serum vitamin D levels and CircS and its components, particularly with short sleep. This suggests a potentially pivotal role of vitamin D in the pathogenesis of Circadian syndrome.
C1 [Arabi, Ahmed; Nasrallah, Dima; Mohsen, Sara; Abugharbieh, Lana; Al-Hashimi, Dana; Almass, Shaikha; Albasti, Shahd; Al-Ajmi, Saeed A.] Qatar Univ, Coll Med, QU Hlth, POB 2713, Doha, Qatar.
   [Khan, Muhammad Naseem] Qatar Univ, Coll Med, Dept Populat Med, QU Hlth, POB 2713, Doha, Qatar.
   [Zughaier, Susu M.] Qatar Univ, Coll Med, Dept Basic Med Sci, QU Hlth, POB 2713, Doha, Qatar.
C3 Qatar University; Qatar University; Qatar University
RP Khan, MN (corresponding author), Qatar Univ, Coll Med, Dept Populat Med, QU Hlth, POB 2713, Doha, Qatar.; Zughaier, SM (corresponding author), Qatar Univ, Coll Med, Dept Basic Med Sci, QU Hlth, POB 2713, Doha, Qatar.
EM naseem@qu.edu.qa; szughaier@qu.edu.qa
RI Zughaier, Susu/N-3185-2019; Khan, Muhammad/H-7722-2016
OI Zughaier, Susu/0000-0001-7487-8770; Arabi, Ahmed/0009-0009-1543-8287;
   Khan, Muhammad Naseem/0000-0002-0484-0985
FX The authors would like to thank the staff at the National Center for
   Health Statistics of the Centers for Disease Control for their efforts
   in designing, collecting, and organizing the NHANES data, as well as for
   creating the public database. The authors also thank Suhail Doi and
   Tawanda Chivese from the Department of Population Medicine, College of
   Medicine, QU Health, Qatar University for their valuable guidance and
   assistance in conceptualization and data analysis.
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NR 41
TC 5
Z9 5
U1 3
U2 10
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JUL
PY 2024
VL 16
IS 13
AR 2111
DI 10.3390/nu16132111
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA YQ9Y7
UT WOS:001270078700001
PM 38999859
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Asbury, EA
   Slattery, C
   Grant, A
   Evans, L
   Barbir, M
   Collins, P
AF Asbury, Elizabeth A.
   Slattery, Colin
   Grant, Amanda
   Evans, Lynda
   Barbir, Mahmoud
   Collins, Peter
TI Cardiac rehabilitation for the treatment of women with chest pain and
   normal coronary arteries
SO MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY
LA English
DT Article
DE cardiac rehabilitation; chest pain; quality of life; psychology;
   exercise tolerance
ID QUALITY-OF-LIFE; SYNDROME-X; HEART-DISEASE; ANXIETY QUESTIONNAIRE;
   POSTMENOPAUSAL WOMEN; EXERCISE TOLERANCE; ANGINA; DEPRESSION;
   ARTERIOGRAMS; ANGIOGRAMS
AB Objective: To explore cardiac rehabilitation (CR) as a treatment for psychological and physiological morbidity in women with chest pain and normal coronary arteries (cardiac syndrome X).
   Design: Sixty-four women aged 57.3 8.6 years (mean +/- SD) with cardiac syndrome X were randomly assigned to an 8-week phase III CR exercise program or symptom monitoring control. All women completed the Hospital Anxiety and Depression Scale, Health Anxiety Questionnaire, and Short Form-36 before and after intervention and at the 8-week follow-up. CR patients underwent physical assessment before and after CR.
   Results: After CR, patients demonstrated improved symptom severity (2.0 +/- 0.8 vs 1.26 +/- 1.1, P = 0.009), Hospital Anxiety and Depression Scale depression score (8.0 +/- 3.4 vs 6.4 +/- 3.1, P = 0.04), total Health Anxiety Questionnaire score (12.0 +/- 5.5 vs 9.5 +/- 6.0, P = 0.008), health worry (4.5 +/- 3.1 vs 3.52 +/- 2.4, P = 0.025) and interference (2.4 +/- 1.8 vs 1.6 +/- 1.8, P = 0.004), SF-36 physical functioning (53.1 +/- 20.4 vs 62.3 +/- 23.9, P = 0.006), energy (36.3 +/- 20.7 vs 49.8 +/- 19.1, P < 0.001), pain (49.9 +/- 20.7 vs 58.1 +/- 22.9, P = 0.028), and general health (48.8 +/- 17.9 vs 57.6 +/- 17.0, P = 0.01) not found among the control women. Improvements were maintained at follow-up. CR patients showed significant improvements in Shuttle Walk Test performance (326.8 +/- 111.0 vs 423.6 +/- 133.2 in, P < 0.001), diastolic blood pressure (84.7 +/- 9.4 vs 79.7 +/- 7.3 mm Hg, P = 0.007), and body mass index (29.1 +/- 6.0 vs 28.4 +/- 6.17 kg/m(2), p = 0.003).
   Conclusions: An 8-week phase III CR program improves exercise tolerance, quality of life, psychological morbidity, symptom severity, and cardiovascular risk factors in women with cardiac syndrome X.
C1 [Asbury, Elizabeth A.; Collins, Peter] Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, Dept Cardiac Med, London SW3 6LY, England.
   [Slattery, Colin; Grant, Amanda; Evans, Lynda; Barbir, Mahmoud] Royal Brompton & Harefield NHS Trust, Harefield Hosp, London, England.
C3 Imperial College London; Royal Brompton & Harefield NHS Foundation
   Trust; Harefield Hospital; Royal Brompton Hospital
RP Asbury, EA (corresponding author), Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, Dept Cardiac Med, Dovehouse St, London SW3 6LY, England.
EM e.asbury@impedal.ac.uk
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NR 40
TC 38
Z9 44
U1 0
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1072-3714
J9 MENOPAUSE
JI Menopause-J. N. Am. Menopause Soc.
PD MAY-JUN
PY 2008
VL 15
IS 3
BP 454
EP 460
DI 10.1097/gme.0b013e31815982eb
PG 7
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA 298MU
UT WOS:000255692600011
PM 18188136
DA 2025-06-11
ER

PT J
AU Purkayastha, S
   Zhang, H
   Zhang, G
   Ahmed, Z
   Wang, Y
   Cai, DS
AF Purkayastha, Sudarshana
   Zhang, Hai
   Zhang, Guo
   Ahmed, Zaghloul
   Wang, Yi
   Cai, Dongsheng
TI Neural dysregulation of peripheral insulin action and blood pressure by
   brain endoplasmic reticulum stress
SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF
   AMERICA
LA English
DT Article
ID UNFOLDED PROTEIN RESPONSE; CENTRAL-NERVOUS-SYSTEM; BETA/NF-KAPPA-B; ER
   STRESS; GLUCOSE-HOMEOSTASIS; TRANSLATIONAL CONTROL; LEPTIN RESISTANCE;
   OXIDATIVE STRESS; INFLAMMATION; OBESITY
AB Chronic endoplasmic reticulum (ER) stress was recently revealed to affect hypothalamic neuroendocrine pathways that regulate feeding and body weight. However, it remains unexplored whether brain ER stress could use a neural route to rapidly cause the peripheral disorders that underlie the development of type 2 diabetes (T2D) and the metabolic syndrome. Using a pharmacologic model that delivered ER stress inducer thapsigargin into the brain, this study demonstrated that a short-term brain ER stress over 3 d was sufficient to induce glucose intolerance, systemic and hepatic insulin resistance, and blood pressure (BP) increase. The collection of these changes was accompanied by elevated sympathetic tone and prevented by sympathetic suppression. Molecular studies revealed that acute induction of metabolic disorders via brain ER stress was abrogated by NF-kappa B inhibition in the hypothalamus. Therapeutic experiments further revealed that acute inhibition of brain ER stress with tauroursodeoxycholic acid (TUDCA) partially reversed obesity-associated metabolic and blood pressure disorders. In conclusion, ER stress in the brain represents a mediator of the sympathetic disorders that underlie the development of insulin resistance syndrome and T2D.
C1 [Purkayastha, Sudarshana; Zhang, Hai; Zhang, Guo; Wang, Yi; Cai, Dongsheng] Albert Einstein Coll Med, Dept Mol Pharmacol, Bronx, NY 10461 USA.
   [Purkayastha, Sudarshana; Zhang, Hai; Zhang, Guo; Wang, Yi; Cai, Dongsheng] Albert Einstein Coll Med, Diabet Res Ctr, Bronx, NY 10461 USA.
   [Ahmed, Zaghloul] CUNY Coll Staten Isl, Dept Phys Therapy & Neurosci Program, Staten Isl, NY 10314 USA.
C3 Montefiore Medical Center; Albert Einstein College of Medicine; Yeshiva
   University; Yeshiva University; Montefiore Medical Center; Albert
   Einstein College of Medicine; City University of New York (CUNY) System;
   College of Staten Island (CUNY)
RP Cai, DS (corresponding author), Albert Einstein Coll Med, Dept Mol Pharmacol, Bronx, NY 10461 USA.
EM dongsheng.cai@einstein.yu.edu
RI Ahmed, zaghloul/AAV-8812-2021; Cai, Dongsheng/CAH-8271-2022
OI Zhang, Guo/0000-0002-3880-6996
FU National Institutes of Health [R01 DK078750, R01 AG031774]; American
   Diabetes Association [1-07-JF-09]
FX This study was supported by National Institutes of Health Grants R01
   DK078750 and R01 AG031774 and American Diabetes Association Junior
   Faculty Award 1-07-JF-09 (all to D. C.).
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NR 45
TC 138
Z9 153
U1 0
U2 18
PU NATL ACAD SCIENCES
PI WASHINGTON
PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA
SN 0027-8424
J9 P NATL ACAD SCI USA
JI Proc. Natl. Acad. Sci. U. S. A.
PD FEB 15
PY 2011
VL 108
IS 7
BP 2939
EP 2944
DI 10.1073/pnas.1006875108
PG 6
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 721TB
UT WOS:000287377000059
PM 21282643
OA Green Published
DA 2025-06-11
ER

PT J
AU Tyagi, A
   Cohen, M
   Reece, J
   Telles, S
AF Tyagi, Anupama
   Cohen, Marc
   Reece, John
   Telles, Shirley
TI An explorative study of metabolic responses to mental stress and yoga
   practices in yoga practitioners, non-yoga practitioners and individuals
   with metabolic syndrome
SO BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Article
DE Yoga; Meditation; Breathing; Metabolic syndrome; Oxygen consumption;
   Energy Expenditure; Metabolic rate; Stress reactivity; Stress recovery
ID EXAGGERATED CARDIAC REACTIONS; ACUTE PSYCHOLOGICAL STRESS;
   BLOOD-PRESSURE; CARDIOVASCULAR RISK; OXYGEN-CONSUMPTION;
   ENERGY-EXPENDITURE; HATHA YOGA; INDIRECT CALORIMETRY; HEART-RATE;
   REACTIVITY
AB Background: Stress places a metabolic burden on homeostasis and is linked to heightened sympathetic activity, increased energy expenditure and pathology. The yogic state is a hypometabolic state that corresponds with mind-body coherence and reduced stress. This study aimed to investigate metabolic responses to stress and different yoga practices in regular yoga practitioners (YP), non-yoga practitioners (NY) and metabolic syndrome patients (MS).
   Methods: YP (n = 16), NY (n = 15) and MS (n = 15) subjects underwent an experimental protocol that comprised of different 5-minute interventions including mental arithmetic stress test (MAST), alternate nostril breathing (ANB), Kapabhati breathing (KB) and meditation (Med) interspersed with 5 minutes of quiet resting (neutral condition (NC)). During the intervention periods continuous body weight adjusted oxygen consumption (VO2ml/min/kg) was measured using open circuit indirect calorimetry with a canopy hood.
   Results: This is the first study to report oxygen consumption (OC) in yoga practitioners during and after MAST and the first to report both within and between different populations. The results were analysed with SPSS 16 using 3X9 mixed factorial ANOVAs. The single between-subject factor was group (YP, NY and MS), the single within-subject factor was made up of the nine intervention phases (NC1, MAST, NC2, ANB, NC3, KB, NC4, Med, NC5). The results demonstrated that the regular YP group had significantly less OC and greater variability in their OC across all phases compared to the MS group (p =.003) and NY group (p = .01). All groups significantly raised their OC during the mental arithmetic stress, however the MS group had a significantly blunted post-stress recovery whereas the YP group rapidly recovered back to baseline levels with post stress recovery being greater than either the NY group or MS group.
   Conclusions: Yoga practitioners have greater metabolic variability compared to non-yoga practitioners and metabolic syndrome patients with reduced oxygen requirements during resting conditions and more rapid post-stress recovery. OC in metabolic syndrome patients displays significantly blunted post-stress recovery demonstrating reduced metabolic resilience. Our results support the findings of previous randomised trials that suggest regular yoga practice may mitigate against the effects of metabolic syndrome.
C1 [Tyagi, Anupama; Cohen, Marc] RMIT, Bundoora, Vic 3083, Australia.
   [Telles, Shirley] Patanjali Res Fdn, Haridwar 249402, Uttrakhand, India.
C3 Royal Melbourne Institute of Technology (RMIT)
RP Cohen, M (corresponding author), RMIT, West Campus,Bldg 201,Level 4, Bundoora, Vic 3083, Australia.
EM marc.cohen@rmit.edu.au
RI Cohen, Marc/GWV-0933-2022; Telles, Shirley/U-7154-2019
OI Cohen, Marc/0000-0002-5876-6565; Telles, Shirley/0000-0003-3562-1926
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NR 109
TC 14
Z9 16
U1 1
U2 38
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1472-6882
J9 BMC COMPLEM ALTERN M
JI BMC Complement. Altern. Med.
PD NOV 15
PY 2014
VL 14
AR 445
DI 10.1186/1472-6882-14-445
PG 10
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Integrative & Complementary Medicine
GA AX0YH
UT WOS:000346675400002
PM 25398263
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Repousi, N
   Masana, MF
   Sanchez-Niubo, A
   Haro, JM
   Tyrovolas, S
AF Repousi, Nikolena
   Masana, Maria F.
   Sanchez-Niubo, Albert
   Haro, Josep Maria
   Tyrovolas, Stefanos
TI Depression and metabolic syndrome in the older population: A review of
   evidence
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Review
DE Metabolic syndrome; Depression; Older adults
ID PROVISIONAL REPORT; YOUNG-ADULTS; RISK-FACTORS; SYMPTOMS; ASSOCIATION;
   ANXIETY; HEALTH; COMMUNITY; PEOPLE; DIAGNOSIS
AB Background: Metabolic syndrome (MetS) has been shown to be associated with depression in older adults but the results are mixed. We summarized and evaluated the association between depression and MetS in people aged 60 years or over.
   Methods: Relevant published studies from January 1997 to July 2017 were identified by searching two electronic databases: PubMed/Medline and EMBASE. Observational studies were considered.
   Results: Twelve studies were included in the systematic review. Depression seemed to be related with MetS in the majority of the studies (10/12=83.3%). As far as the longitudinal studies are concerned, the onset of depression was related to MetS in 2 out of 3 studies (66.6%), while a relation between chronicity of depression and MetS was reported (1 study). Regarding cross-sectional studies, 7 out of 9 (77.7%) concluded that there was a positive association between depression and MetS. Mixed evidence was found among studies concerning the association between depression and the individual components of MetS. Four out of ten studies (40%) reported that depression was significantly associated with the waist circumference, a component of MetS.
   Limitations: There was a high degree of heterogeneity between studies regarding their design. Only studies written in English, from peer-reviewed journals were included.
   Conclusions: Depression seemed to be significantly associated with MetS in people aged 60 years or over. Among the components of MetS, abdominal obesity seemed to be associated more strongly and consistently with depression. The direction of the causality and mechanisms underlying the relationship are still largely unknown.
C1 [Repousi, Nikolena] Natl & Kapodistrian Univ Athens, Med Sch, Mikras Asias St 75, Athens, Greece.
   [Masana, Maria F.; Sanchez-Niubo, Albert; Haro, Josep Maria; Tyrovolas, Stefanos] Univ Barcelona, Fundacio Sant Joan Deu, Dr Antoni Pujadas 42,Parc Sanitari Sant Joan Deu, Barcelona, Spain.
   [Masana, Maria F.; Sanchez-Niubo, Albert; Haro, Josep Maria; Tyrovolas, Stefanos] CIBERSAM, Ctr Invest Biomed Red Salud Mental, Inst Salud Carlos 3, Monforte Lemos 3-5, Madrid 28029, Spain.
   [Masana, Maria F.] Univ Barcelona, Fac Med, Casanova 143, E-08036 Barcelona, Spain.
   [Tyrovolas, Stefanos] Univ Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,mSuite 600, Seattle, WA 98121 USA.
C3 National & Kapodistrian University of Athens; University of Barcelona;
   Instituto de Salud Carlos III; CIBER - Centro de Investigacion Biomedica
   en Red; CIBERSAM; University of Barcelona; University of Washington;
   University of Washington Seattle; Institute for Health Metrics &
   Evaluation
RP Tyrovolas, S (corresponding author), CIBERSAM, Fundacio Sant Joan de Deu, Dr Antoni Pujadas,42 St Boi Llobregat, Barcelona, Spain.
EM s.tyrovolas@pssjd.org
RI Haro, Josep Maria/D-1423-2011; Tyrovolas, Stefanos/M-2758-2014;
   Sanchez-Niubo, Albert/B-7517-2014
OI Sanchez-Niubo, Albert/0000-0003-0309-181X
FU Foundation for Education and European Culture (IPEP); Sara Borrell
   postdoctoral program from the Instituto de Salud Carlos III (ISCIII -
   Spain) [CD15/00019]; Fondos Europeo de Desarrollo Regional (FEDER);
   M-AES from the Instituto de Salud Carlos III [MV16/00035]
FX Stefanos Tyrovolas was supported by the Foundation for Education and
   European Culture (IPEP), the Sara Borrell postdoctoral program
   (reference no. CD15/00019 from the Instituto de Salud Carlos III (ISCIII
   - Spain) and the Fondos Europeo de Desarrollo Regional (FEDER). Stefanos
   was awarded with a 6 months visiting fellowship funding at IHME from
   M-AES (reference no. MV16/00035 from the Instituto de Salud Carlos III).
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NR 66
TC 48
Z9 58
U1 1
U2 25
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD SEP
PY 2018
VL 237
BP 56
EP 64
DI 10.1016/j.jad.2018.04.102
PG 9
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA GH9DJ
UT WOS:000433968900008
PM 29772477
DA 2025-06-11
ER

PT J
AU Miola, A
   Pinna, M
   Manchia, M
   Tondo, L
   Baldessarini, RJ
AF Miola, Alessandro
   Pinna, Marco
   Manchia, Mirko
   Tondo, Leonardo
   Baldessarini, Ross J.
TI Overweight in mood disorders: Effects on morbidity and treatment
   response
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Affective; BMI; Body-weight; Depression; Mood; Obesity; Treatment
   response
ID BODY-MASS INDEX; MAJOR DEPRESSIVE DISORDER; BIPOLAR-DISORDER; SEDENTARY
   BEHAVIOR; METABOLIC SYNDROME; TREATMENT OUTCOMES; PHYSICAL-ACTIVITY;
   MENTAL-HEALTH; OBESITY; WEIGHT
AB Objective: As it is not clear how body-mass index (BMI) may relate to diagnosis, symptom-severity, illness-course, and treatment-response among psychiatric patients, we related BMI to psychiatric diagnosis and to selected clinical and demographic factors in major affective disorder subjects.
   Methods: We analyzed mean BMI levels vs. diagnosis, and evaluated selected risk factors for association with overweight and obesity among subjects with DSM-5 major affective disorders.
   Results: In 1884 subjects, BMI ranged from 23.4 kg/m(2) with anxiety disorders to 27.6 with psychotic disorders, and averaged 24.1 among 1469 affective disorder subjects. Mood-disorder subjects with BMI >= 25 (overweight/ obese) were more likely: men, older, married, with more children and siblings, less education, lower socioeconomic status, engaged less in physical exercise, smoked more, and lived in less densely populated areas. They also were more likely to have: BD than MDD, familial mood disorders, no co-occurring ADHD, higher serum triglyceride levels, more time depressed and less improvement in depression ratings with treatment.
   Conclusions: Risk of being overweight or obese was greatest with psychoses, least with anxiety, personality, and minor depressive disorders, and intermediate with major mood disorders. Several plausible risk factors for high BMI were identified in mood disorder subjects, including male sex and with BD > MDD. Striking were selectively greater prospective morbidity and decreased treatment-response for depression vs. mania with BMI >= 25.
C1 [Miola, Alessandro] Univ Padua, Dept Neurosci DNS, Padua, Italy.
   [Miola, Alessandro; Pinna, Marco; Manchia, Mirko; Tondo, Leonardo; Baldessarini, Ross J.] McLean Hosp, Mailman Res Ctr, Int Consortium Mood & Psychot Disorders Res, 115 Mill St, Belmont, MA 02178 USA.
   [Pinna, Marco; Tondo, Leonardo] Lucio Bini Mood Disorders Ctr, Via Cavalcanti 28, Rome, Italy.
   [Pinna, Marco; Manchia, Mirko] Univ Cagliari, Dept Med Sci & Publ Hlth, Sect Psychiat, Cagliari, Italy.
   [Manchia, Mirko] Dalhousie Univ, Dept Pharmacol, Halifax, NS, Canada.
   [Tondo, Leonardo; Baldessarini, Ross J.] Harvard Med Sch, Dept Psychiat, Boston, MA 02115 USA.
C3 University of Padua; Harvard University; Harvard University Medical
   Affiliates; McLean Hospital; University of Cagliari; Dalhousie
   University; Harvard University; Harvard Medical School
RP Tondo, L (corresponding author), Ctr Lucio Bini, Via Cavalcanti 28, Cagliari, Italy.
EM Ltondo@aol.com
RI Miola, Alessandro/LMP-0749-2024; Baldessarini, Ross/ADO-8296-2022;
   Manchia, Mirko/A-2907-2010
FU Aretaeus Foundation of Rome; Bruce J. Anderson Foundation; McLean
   Private Donors Psychiatry Research Fund
FX Supported by a grant from the Aretaeus Foundation of Rome (to LT), and a
   grant from the Bruce J. Anderson Foundation and the McLean Private
   Donors Psychiatry Research Fund (to RJB).
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NR 88
TC 9
Z9 9
U1 0
U2 7
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD JAN 15
PY 2022
VL 297
BP 169
EP 175
DI 10.1016/j.jad.2021.10.032
EA OCT 2021
PG 7
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA XO0CR
UT WOS:000729864000020
PM 34699849
DA 2025-06-11
ER

PT J
AU Rajan, TM
   Menon, V
AF Rajan, T. M.
   Menon, V
TI Psychiatric disorders and obesity: A review of association studies
SO JOURNAL OF POSTGRADUATE MEDICINE
LA English
DT Review
DE Anxiety; depression; metabolic syndrome; obesity; psychiatry; review
ID BODY-MASS INDEX; PATIENTS RECEIVING CLOZAPINE; METABOLIC SYNDROME;
   CHILDHOOD OVERWEIGHT; DEPRESSIVE SYMPTOMS; GENDER-DIFFERENCES; ANXIETY
   DISORDERS; ABDOMINAL OBESITY; MENTAL-DISORDERS; POPULATION
AB Background: Inconsistent evidence exists regarding the strength, direction, and moderators in the relationship between obesity and psychiatric disorders. Aim: This study aims to summarize the evidence on the association between psychiatric illness and obesity with particular attention to the strength and direction of association and also the possible moderators in each postulated link. Materials and Methods: Systematic electronic searches of MEDLINE through PubMed, ScienceDirect, PsycINFO, and Google Scholar were carried out from inception till October 2016. Generated abstracts were screened for eligibility to be included in the review. Study designs that evaluated the strength of relationship between obesity and psychiatric disorders were included in the study. Quality assessment of included studies was done using the NewcastleuOttawa checklist tool. Results: From a total of 2424 search results, 21 eligible articles were identified and reviewed. These included studies on obesity and depression (n = 15), obesity and anxiety (four) and one each on obesity and personality disorders, eating disorder (ED), attention deficit hyperactivity disorder, and alcohol use. Maximal evidence existed for the association between depression and obesity with longitudinal studies demonstrating a bidirectional link between the two conditions. The odds ratios (ORs) were similar for developing depression in obesity (OR: 1.21u5.8) and vice versa (OR: 1.18u3.76) with a stronger association observed in women. For anxiety disorders, evidence was mostly cross-sectional, and associations were of modest magnitude (OR: 1.27u1.40). Among other disorders, obesity, and EDs appear to have a close link (OR: 4.5). Alcohol use appears to be a risk factor for obesity and not vice versa but only among women (OR: 3.84). Conclusion: Obesity and depression have a significant and bidirectional association. Evidence is modest for anxiety disorders and inadequate for other psychiatric conditions. Gender appears to be an important mediator in these relationships.
C1 [Rajan, T. M.; Menon, V] Jawaharlal Inst Postgrad Med Educ & Res, Dept Psychiat, Pondicherry, India.
C3 Jawaharlal Institute of Postgraduate Medical Education & Research
RP Menon, V (corresponding author), Jawaharlal Inst Postgrad Med Educ & Res, Dept Psychiat, Pondicherry, India.
EM drvmenon@gmail.com
RI Menon, Vikas/F-3100-2012
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NR 69
TC 249
Z9 274
U1 2
U2 24
PU MEDKNOW PUBLICATIONS & MEDIA PVT LTD
PI MUMBAI
PA B-9, KANARA BUSINESS CENTRE, OFF LINK RD, GHAKTOPAR-E, MUMBAI, 400075,
   INDIA
SN 0022-3859
J9 J POSTGRAD MED
JI J. Postgrad. Med.
PD JUL-SEP
PY 2017
VL 63
IS 3
BP 182
EP 190
DI 10.4103/jpgm.JPGM_712_16
PG 9
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA FB1HM
UT WOS:000405894500009
PM 28695871
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Santos, CJ
   Ferreira, AVM
   Oliveira, AL
   Oliveira, MC
   Gomes, JS
   Aguiar, DC
AF Santos, Carla J.
   Ferreira, Adaliene V. M.
   Oliveira, Ana L.
   Oliveira, Marina C.
   Gomes, Julia S.
   Aguiar, Daniele C.
TI Carbohydrate-enriched diet predispose to anxiety and depression-like
   behavior after stress in mice
SO NUTRITIONAL NEUROSCIENCE
LA English
DT Article
DE Anxiety; Depression; Carbohydrate diet; Stress
ID MOOD DISORDERS; ANIMAL-MODELS; LEPTIN ACTION; OBESITY;
   NEUROINFLAMMATION; INFLAMMATION; ACTIVATION; MECHANISMS; ADIPOKINES;
   REACTIVITY
AB Objectives: Obesity is a chronic disease frequently associated with serious co-morbidities, such as diabetes type II, metabolic syndrome, and psychiatric disorders. Little is known, however, regarding the behavioral consequences of modified diet constituents and the propensity to development of stress related disorders. Thus, the aim of this study was to verify whether chronic exposure to a normocaloric/high-carbohydrate diet will modify the animal's behavior after different stressful stimuli.
   Methods: BALB/c mice were fed for 12 weeks with a standard chow diet or high refined carbohydrate-containing diet (HC). Following this period, independent groups of animals were exposed to different stress paradigms: 1 - two hours of restraint stress followed by exposure to the Elevated Plus Maze test (EPM) 24 hours later; 2 - The contextual fear conditioning (CFC) test and 3 - the tail suspension test (TST).
   Results: Despite no change on total body weight, animals fed with HC diet showed increase in serum leptin levels and higher adiposity compared to diet control group. In behavioral tests, animals from HC diet group displayed reduction in the percentage of entries into the open arms of the EPM, evaluated 24 hours after restraint stress, suggesting an anxiogenic-like effect. It is also observed increase in aversive memory in the CFC test and depressive-like behavior in TST.
   Discussion: Our results suggest that a moderate obesity, induced by high refined carbohydrate diet, may facilitate the development of anxiety and depressive-like behaviors after the stress. The mechanisms responsible for such effects remain to be elucidated.
C1 [Santos, Carla J.; Oliveira, Ana L.; Gomes, Julia S.; Aguiar, Daniele C.] Univ Fed Minas Gerais, Inst Biol Sci ICB, Dept Pharmacol, Av Pres Antonio Carlos 6627, BR-31270901 Belo Horizonte, MG, Brazil.
   [Ferreira, Adaliene V. M.; Oliveira, Marina C.] Univ Fed Minas Gerais, Nursing Sch, Dept Nutr, Belo Horizonte, MG, Brazil.
C3 Universidade Federal de Minas Gerais; Universidade Federal de Minas
   Gerais
RP Aguiar, DC (corresponding author), Univ Fed Minas Gerais, Inst Biol Sci ICB, Dept Pharmacol, Av Pres Antonio Carlos 6627, BR-31270901 Belo Horizonte, MG, Brazil.
EM danieleaguiar@ufmg.br
RI Aguiar, Daniele/F-9494-2018; Ferreira, adaliene/G-8523-2011; Chaves de
   Oliveira, Marina/E-7895-2018
OI Ferreira, adaliene/0000-0003-2256-8652; De Aguiar, Daniele
   Cristina/0000-0001-7635-8656; Chaves de Oliveira,
   Marina/0000-0002-7423-9802
FU Capes; CNPq [477541/2012-7]
FX The authors would like to thanks the financial support from Capes and
   CNPq (477541/2012-7).
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NR 53
TC 32
Z9 33
U1 4
U2 30
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1028-415X
EI 1476-8305
J9 NUTR NEUROSCI
JI Nutr. Neurosci.
PY 2018
VL 21
IS 1
BP 33
EP 39
DI 10.1080/1028415X.2016.1213529
PG 7
WC Neurosciences; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Nutrition & Dietetics
GA FR9MI
UT WOS:000419397400004
PM 27472404
DA 2025-06-11
ER

PT J
AU Correll, CU
   Robinson, DG
   Schooler, NR
   Brunette, MF
   Mueser, KT
   Rosenheck, RA
   Marcy, P
   Addington, J
   Estroff, SE
   Robinson, J
   Penn, DL
   Azrin, S
   Goldstein, A
   Severe, J
   Heinssen, R
   Kane, JM
AF Correll, Christoph U.
   Robinson, Delbert G.
   Schooler, Nina R.
   Brunette, Mary F.
   Mueser, Kim T.
   Rosenheck, Robert A.
   Marcy, Patricia
   Addington, Jean
   Estroff, Sue E.
   Robinson, James
   Penn, David L.
   Azrin, Susan
   Goldstein, Amy
   Severe, Joanne
   Heinssen, Robert
   Kane, John M.
TI Cardiometabolic Risk in Patients With First-Episode Schizophrenia
   Spectrum Disorders Baseline Results From the RAISE-ETP Study
SO JAMA PSYCHIATRY
LA English
DT Article
ID NUTRITION EXAMINATION SURVEY; 3RD NATIONAL-HEALTH; DENSITY-LIPOPROTEIN
   CHOLESTEROL; FASTING PLASMA-GLUCOSE; METABOLIC SYNDROME; UNITED-STATES;
   SCHIZOAFFECTIVE DISORDER; ANTIPSYCHOTIC-DRUGS; CARDIOVASCULAR RISK;
   PHYSICAL ILLNESS
AB IMPORTANCE The fact that individuals with schizophrenia have high cardiovascular morbidity and mortality is well established. However, risk status and moderators or mediators in the earliest stages of illness are less clear. OBJECTIVE To assess cardiometabolic risk in first-episode schizophrenia spectrum disorders (FES) and its relationship to illness duration, antipsychotic treatment duration and type, sex, and race/ethnicity.
   DESIGN, SETTING, AND PARTICIPANTS Baseline results of the Recovery After an Initial Schizophrenia Episode (RAISE) study, collected between July 22, 2010, and July 5, 2012, from 34 community mental health facilities without major research, teaching, or clinical FES programs. Patients were aged 15 to 40 years, had research-confirmed diagnoses of FES, and had less than 6 months of lifetime antipsychotic treatment.
   EXPOSURE Prebaseline antipsychotic treatment was based on the community clinician's and/or patient's decision.
   MAIN OUTCOMES AND MEASURES Body composition and fasting lipid, glucose, and insulin parameters.
   RESULTS In 394 of 404 patients with cardiometabolic data (mean [SD] age, 23.6 [5.0] years; mean [SD] lifetime antipsychotic treatment, 47.3 [46.1] days), 48.3% were obese or overweight, 50.8% smoked, 56.5% had dyslipidemia, 39.9% had prehypertension, 10.0% had hypertension, and 13.2% had metabolic syndrome. Prediabetes (glucose based, 4.0%; hemoglobin A(1c) based, 15.4%) and diabetes (glucose based, 3.0%; hemoglobin A1c based, 2.9%) were less frequent. Total psychiatric illness duration correlated significantly with higher body mass index, fat mass, fat percentage, and waist circumference (all P < .01) but not elevated metabolic parameters (except triglycerides to HDL-C ratio [P = .04]). Conversely, antipsychotic treatment duration correlated significantly with higher non-HDL-C, triglycerides, and triglycerides to HDL-C ratio and lower HDL-C and systolic blood pressure (all P <= .01). Olanzapine was significantly associated with higher triglycerides, insulin, and insulin resistance, whereas quetiapine fumarate was associated with significantly higher triglycerides to HDL-C ratio (all P <= .02).
   CONCLUSIONS AND RELEVANCE In patients with FES, cardiometabolic risk factors and abnormalities are present early in the illness and likely related to the underlying illness, unhealthy lifestyle, and antipsychotic medications, which interact with each other. Prevention of and early interventions for psychiatric illness and treatment with lower-risk agents, routine antipsychotic adverse effect monitoring, and smoking cessation interventions are needed from the earliest illness phases.
C1 [Correll, Christoph U.; Robinson, Delbert G.; Schooler, Nina R.; Marcy, Patricia; Kane, John M.] Zucker Hillside Hosp, North Shore LIJ Hlth Syst, Div Psychiat Res, Glen Oaks, NY 11004 USA.
   [Correll, Christoph U.; Robinson, Delbert G.; Marcy, Patricia; Kane, John M.] Feinstein Inst Med Res, Manhasset, NY USA.
   [Correll, Christoph U.; Robinson, Delbert G.; Robinson, James; Kane, John M.] Hofstra North Shore LIJ Sch Med, Hempstead, NY USA.
   [Correll, Christoph U.; Robinson, Delbert G.; Kane, John M.] Albert Einstein Coll Med, Bronx, NY 10467 USA.
   [Schooler, Nina R.] Suny Downstate Med Ctr, New York, NY USA.
   [Brunette, Mary F.] Geisel Sch Med Dartmouth, Hanover, NH USA.
   [Brunette, Mary F.] Dept Hlth & Human Serv, Bur Behav Hlth, Hanover, NH USA.
   [Mueser, Kim T.] Boston Univ, Ctr Psychiat Rehabil, Dept Occupat Therapy, Boston, MA 02215 USA.
   [Mueser, Kim T.] Boston Univ, Ctr Psychiat Rehabil, Dept Psychiat, Boston, MA 02215 USA.
   [Mueser, Kim T.] Boston Univ, Ctr Psychiat Rehabil, Dept Psychol, Boston, MA 02215 USA.
   [Rosenheck, Robert A.] Yale Univ, Dept Psychiat & Epidemiol, Princeton, NJ USA.
   [Rosenheck, Robert A.] Yale Univ, Dept Publ Hlth, Princeton, NJ USA.
   [Addington, Jean] Univ Calgary, Hotchkiss Brain Inst, Dept Psychiat, Calgary, AB, Canada.
   [Estroff, Sue E.] Univ N Carolina, Dept Social Med, Chapel Hill, NC USA.
   [Robinson, James] Nathan S Kline Inst Psychiat Res, Orangeburg, NY USA.
   [Penn, David L.] Univ N Carolina, Dept Psychol, Chapel Hill, NC USA.
   [Azrin, Susan; Goldstein, Amy; Severe, Joanne; Heinssen, Robert] NIMH, Bethesda, MD 20892 USA.
C3 Northwell Health; Northwell Health; Hofstra University; Northwell
   Health; Montefiore Medical Center; Albert Einstein College of Medicine;
   Yeshiva University; State University of New York (SUNY) System; SUNY
   Downstate Health Sciences University; Dartmouth College; Boston
   University; Boston University; Boston University; Yale University; Yale
   University; University of Calgary; University of North Carolina;
   University of North Carolina Chapel Hill; Nathan Kline Institute for
   Psychiatric Research; University of North Carolina; University of North
   Carolina Chapel Hill; National Institutes of Health (NIH) - USA; NIH
   National Institute of Mental Health (NIMH)
RP Correll, CU (corresponding author), Zucker Hillside Hosp, North Shore LIJ Hlth Syst, Div Psychiat Res, 75-59 263rd St, Glen Oaks, NY 11004 USA.
EM ccorrell@lij.edu
RI Schooler, Nina/M-4965-2017; Penn, David/AFT-9440-2022; Kane,
   Jeremy/JTU-1481-2023; Estroff, Sue/AAA-1300-2021; Heinssen,
   Robert/ACV-7271-2022; Robinson, Jim/D-9096-2016; Correll,
   Christoph/D-3530-2011; Addington, Jean/ACR-3912-2022
OI Kane, John/0000-0002-2628-9442; Brunette, Mary/0000-0002-0713-8745;
   Penn, David/0000-0003-4567-0166
FU National Institute of Mental Health [HHSN-271-2009-00019C]; American
   Recovery and Reinvestment Act
FX This work was supported in part by grant HHSN-271-2009-00019C from the
   National Institute of Mental Health (Dr Kane) and by federal funds from
   the American Recovery and Reinvestment Act.
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NR 79
TC 318
Z9 335
U1 4
U2 62
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 2168-622X
EI 2168-6238
J9 JAMA PSYCHIAT
JI JAMA Psychiatry
PD DEC
PY 2014
VL 71
IS 12
BP 1350
EP 1363
DI 10.1001/jamapsychiatry.2014.1314
PG 14
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA AU9MQ
UT WOS:000345917900007
PM 25321337
DA 2025-06-11
ER

PT J
AU Lee, SH
   Shin, C
   Ko, YH
   Lee, MS
   Park, MH
   Pae, CU
   Yoon, HK
   Han, C
AF Lee, Seung-Hoon
   Shin, Cheolmin
   Ko, Young-Hoon
   Lee, Moon -Soo
   Park, Moon Ho
   Pae, Chi-Un
   Yoon, Ho-Kyoung
   Han, Changsu
TI Plasminogen Activator Inhibitor-1: Potential Inflammatory Marker in
   Late-life Depression
SO CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE
LA English
DT Article
DE Depression; Plasminogen activator inhibitor 1; Adipokine; Inflammation;
   Metabolic syndrome
ID METABOLIC SYNDROME; INSULIN SENSITIVITY; CARDIOVASCULAR RISK; GRADE
   INFLAMMATION; KOREAN VERSION; SERUM-LEVELS; ADIPONECTIN; OBESITY; BRAIN;
   BIOMARKER
AB Objective: Although several previous studies have examined the association between late-life depression and blood adipokine levels, a marker of chronic inflammation, no studies have comprehensively considered the effects of metabolic syndrome, which is known to affect blood adipokine levels. This study examined blood adipokine levels in geriatric depression after adjusting for the effects of metabolic syndrome. Methods: Participants were selected from the Ansan Geriatric Study (depression group [n = 76] and control group [n = 76]). Blood concentrations of four adipokines (adiponectin, resistin, neutrophil-gelatinase-associated lipocalin [NGAL], and plasminogen activator inhibitor-1 [PAI-1]) were measured using immunoassays. The effects of blood adipokine concentration on the diagnosis of depression were analyzed using multivariate logistic regression to adjust for the effects of metabolic syndrome and potential confounding factors. Results: When the effects of metabolic syndrome and potential confounding factors were adjusted, only PAI-1 could explain the diagnosis of depression among all the adipokines. The depression group showed a lower blood PAI-1 level than the control group. Adiponectin, resistin, and NGAL could not explain the diagnosis of depression when the effects of metabolic syndrome and potential confounding factors were adjusted. Conclusion: This study suggests the possibility that the blood PAI-1 levels in clinically pathological late-life depression may show contrasting results to those with subclinical depressive symptoms. Additionally, considering that most previous studies have been conducted with pre-geriatric populations, the study suggests the possibility that geriatric depression may show inflammatory changes with patterns that are different from those of depression in the pre-geriatric population.
C1 [Lee, Seung-Hoon] Korea Univ, Dept Psychiat, Vet Hlth Serv Med Ctr, Coll Med, Seoul, South Korea.
   [Shin, Cheolmin; Ko, Young-Hoon; Lee, Moon -Soo; Han, Changsu] Korea Univ, Dept Psychiat, Coll Med, Seoul, South Korea.
   [Park, Moon Ho] Korea Univ, Dept Neurol, Coll Med, Seoul, South Korea.
   [Pae, Chi-Un] Catholic Univ Korea, Coll Med, Dept Psychiat, Seoul, South Korea.
   [Han, Changsu] Korea Univ, Coll Med, Dept Psychiat, Guro Hosp, 148 Gurodong Ro, Seoul 08308, South Korea.
C3 Veterans Health Service Medical Center; Korea University; Korea
   University Medicine (KU Medicine); Korea University; Korea University
   Medicine (KU Medicine); Korea University; Korea University Medicine (KU
   Medicine); Catholic University of Korea; Korea University; Korea
   University Medicine (KU Medicine)
RP Han, C (corresponding author), Korea Univ, Coll Med, Dept Psychiat, Guro Hosp, 148 Gurodong Ro, Seoul 08308, South Korea.
EM hancs@korea.ac.kr
RI Shin, Cheolmin/AAX-7092-2020; Pae, Chi-Un/AAG-5752-2020; Lee,
   Seung-Hoon/HPC-3773-2023; Han, Changsu/H-9926-2013; Lee,
   Moon-Soo/B-1203-2016
OI Lee, Seung-Hoon/0000-0001-5341-0933; Han, Changsu/0000-0002-4021-8907;
   Park, Moon Ho/0000-0002-4892-3475; Ko, Young-Hoon/0000-0002-5352-2158;
   Shin, Cheolmin/0000-0002-8232-2921; Lee, Moon-Soo/0000-0003-0729-6943
FU Ministry of Trade, Industry, and Energy (MOTIE) , Korea; Fostering
   Program for The Value-Chain through Industrial Intelligence [P0017821];
   Korea Institute for Advancement of Technology (KIAT)
FX This research was financially supported by the Ministry of Trade,
   Industry, and Energy (MOTIE) , Korea, under the Fostering Program for
   The Value-Chain through Industrial Intelligence (reference number
   P0017821) supervised by the Korea Institute for Advancement of
   Technology (KIAT) .
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NR 71
TC 7
Z9 7
U1 1
U2 11
PU KOREAN COLL NEUROPSYCHOPHARMACOLOGY
PI SEOUL
PA RN 1003 OFFICETEL 40, 63-RO YEONGDEUNGPO-GU, SEOUL, 150-731, SOUTH KOREA
SN 1738-1088
EI 2093-4327
J9 CLIN PSYCHOPHARM NEU
JI Clin. Psychopharmacol. Neurosci.
PD FEB
PY 2023
VL 21
IS 1
BP 147
EP 161
DI 10.9758/cpn.2023.21.1.147
PG 15
WC Neurosciences; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pharmacology & Pharmacy
GA 8S2EE
UT WOS:000928396500011
PM 36700321
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Wong, EML
   Leung, DYP
   Wang, Q
   Leung, AYM
   Cheung, ASP
AF Wong, Eliza Mi Ling
   Leung, Doris Yin Ping
   Wang, Qun
   Leung, Angela Yee Man
   Cheung, Alice Siu Ping
TI The effect of a lifestyle intervention program using a mobile
   application versus the effect of a program using a booklet for adults
   with metabolic syndrome: A three-arm randomized controlled trial
SO JOURNAL OF NURSING SCHOLARSHIP
LA English
DT Article
DE body weight; exercise; lifestyle intervention; m-health; metabolic
   syndrome
ID WEIGHT-LOSS; PHYSICAL-ACTIVITY; EXERCISE; TECHNOLOGY; IMPROVES; IMPACT
AB Purpose: The research aimed to examine the effect of a lifestyle intervention program using mobile application versus booklet for adults with metabolic syndrome in Hong Kong. The outcomes comprised body weight (primary outcome), exercise amount, improvement of cardiometabolic risk factors, cardiovascular endurance, perceived stress scale, and exercise self-efficacy.Design: A three-arm randomized controlled trial namely App group, Booklet group, and control group was adopted.Methods: Two hundred sixty-four adults with metabolic syndrome were recruited from community centers from 2019 to December 2021. Inclusion criteria are those adults with metabolic syndrome, able to use a smart phone. All participants received a 30-min health talk. App group additionally received a mobile application, while Booklet group received a booklet, and the control group received a placebo booklet. Data were collected at baseline, Weeks 4, 12, and 24. SPSS and generalized estimating equations (GEE) model were employed for data analysis.Findings: Attrition rates were minimal, ranged from 2.65% to 6.44%. Both app and booklet group showed significant improvement in outcomes (exercise amount, waist circumference) when compared to control group. However, statistically significant and superior results were observed in app group, including body weight, exercise amount, waist circumference, body mass index, and systolic blood pressure when compared to booklet group.Conclusion: The lifestyle intervention supported with app was found to be superior to the booklet support for reducing body weight and maintaining exercise.Clinical Relevance: The lifestyle intervention program using mobile application support could be used widely for adults with metabolic syndrome in the community. Suggest nurses may incorporate this program in their health promotion strategies focusing on a healthy lifestyle to reduce the risk of progression to metabolic syndrome.
C1 [Wong, Eliza Mi Ling] Tung Wah Coll, Sch Nursing, Hong Kong, Peoples R China.
   [Leung, Doris Yin Ping; Leung, Angela Yee Man; Cheung, Alice Siu Ping] Hong Kong Polytech Univ, Sch Nursing, Hong Kong, Peoples R China.
   [Wang, Qun] Shenzhen Univ, Sch Nursing, Shenzhen, Peoples R China.
C3 Tung Wah College; Hong Kong Polytechnic University; Shenzhen University
RP Leung, DYP (corresponding author), Hong Kong Polytech Univ, Sch Nursing, Hong Kong, Peoples R China.
EM doris.yp.leung@polyu.edu.hk
RI WANG, Qun/AAP-9908-2021; Leung, Angela/X-4415-2019; Wong,
   Eliza/AAH-6193-2020; Leung, Doris/T-6985-2019; Leung, Doris
   Y.P./K-4878-2014; Leung, Angela YM/C-4768-2009
OI Wong, Eliza ML/0000-0003-0698-9000; Leung, Doris
   Y.P./0000-0003-0138-8839; Leung, Angela YM/0000-0002-9836-1925
FU Health and Medical Research Fund, Food and Health Bureau, Hong Kong SAR
   [10110301]
FX Health and Medical Research Fund, Food and Health Bureau, Hong Kong SAR,
   Grant/Award Number: 10110301This research is supported by the Health and
   Medical Research Fund (No. 10110301), Food and Health Bureau, Hong Kong
   SAR
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NR 47
TC 11
Z9 11
U1 1
U2 20
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1527-6546
EI 1547-5069
J9 J NURS SCHOLARSHIP
JI J. Nurs. Scholarsh.
PD SEP
PY 2023
VL 55
IS 5
BP 936
EP 948
DI 10.1111/jnu.12883
EA MAR 2023
PG 13
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA S0GV9
UT WOS:000959318900001
PM 36896916
DA 2025-06-11
ER

PT J
AU Hoerster, KD
   Campbell, S
   Dolan, M
   Stappenbeck, CA
   Yard, S
   Simpson, T
   Nelson, KM
AF Hoerster, Katherine D.
   Campbell, Sarah
   Dolan, Marketa
   Stappenbeck, Cynthia A.
   Yard, Samantha
   Simpson, Tracy
   Nelson, Karin M.
TI PTSD is associated with poor health behavior and greater Body Mass Index
   through depression, increasing cardiovascular disease and diabetes risk
   among US veterans
SO PREVENTIVE MEDICINE REPORTS
LA English
DT Article
DE PTSD; Depression; Cardiovascular disease; Diabetes; Health behavior
ID POSTTRAUMATIC-STRESS-DISORDER; PHYSICAL-ACTIVITY; MENTAL-HEALTH;
   METABOLIC SYNDROME; SERVICE MEMBERS; UNITED-STATES; SELF-REPORTS;
   WEIGHT-LOSS; EXERCISE; SYMPTOMS
AB Posttraumatic stress disorder (PTSD) is a risk factor for cardiovascular disease (CVD) and diabetes. Dedert and colleagues hypothesized a model whereby PTSD leads to poor health behaviors, depression, and pre-clinical disease markers, and that these factors lead to CVD and diabetes (Ann Behav Med, 2010, 61-78). This study provides a preliminary test of that model. Using data from a mailed cross-sectional survey conducted 2012-2013, path analysis was conducted among N = 657 with complete demographic data. We first analyzed the hypothesized model, followed by four alternatives, to identify the best-fitting model. The alternate model that specified pathways from depression to health behaviors had the best fit. Contrary to hypotheses, higher PTSD symptoms were associated with better physical activity and diet quality. Of the specific indirect pathways from PTSD to Body Mass Index (BMI), only the path through depression was significant. Higher depression symptoms were significantly associated with less physical activity, poorer diet, and greater likelihood of smoking. In addition, the specific indirect effect from depression to BMI through physical activity was significant. Current smoking and higher BMI were associated with greater likelihood of diabetes, and hypertension was associated with greater likelihood of CVD. PTSD symptoms may increase risk for CVD and diabetes through the negative impact of depression on health behaviors and BMI. With or without PTSD, depression may be an important target in interventions targeting cardiovascular and metabolic diseases among veterans.
C1 [Hoerster, Katherine D.; Campbell, Sarah; Nelson, Karin M.] VA Puget Sound Healthcare Syst, Seattle Div, Hlth Serv Res & Dev Serv, 1660 South Columbian Way,S-152, Seattle, WA 98108 USA.
   [Hoerster, Katherine D.; Campbell, Sarah; Dolan, Marketa; Yard, Samantha; Simpson, Tracy] VA Puget Sound Healthcare Syst, Seattle Div, Mental Hlth Serv, 1660 South Columbian Way,S-116, Seattle, WA 98108 USA.
   [Hoerster, Katherine D.; Campbell, Sarah; Stappenbeck, Cynthia A.; Simpson, Tracy] Univ Washington, Dept Psychiat & Behav Sci, 1100 NE 45th St,Suite 300, Seattle, WA 98105 USA.
   [Simpson, Tracy] VA Puget Sound Hlth Care, Ctr Excellence Subst Addict Treatment & Educ, 1660 S Columbian Way, Seattle, WA 98108 USA.
   [Nelson, Karin M.] VA Puget Sound Healthcare Syst, Gen Internal Med Serv, 1660 South Columbian Way, Seattle, WA 98108 USA.
   [Nelson, Karin M.] Univ Washington, Dept Med, 1959 NE Pacific St, Seattle, WA 98195 USA.
C3 US Department of Veterans Affairs; Veterans Health Administration (VHA);
   Vet Affairs Puget Sound Health Care System; US Department of Veterans
   Affairs; Veterans Health Administration (VHA); Vet Affairs Puget Sound
   Health Care System; University of Washington; University of Washington
   Seattle; US Department of Veterans Affairs; Veterans Health
   Administration (VHA); Vet Affairs Puget Sound Health Care System; US
   Department of Veterans Affairs; Veterans Health Administration (VHA);
   Vet Affairs Puget Sound Health Care System; University of Washington;
   University of Washington Seattle
RP Hoerster, KD (corresponding author), 1660 South Columbian Way,S-152, Seattle, WA 98108 USA.
EM Katherine.Hoerster@va.gov; Sarah.Campbell6@va.gov; Marketa.Dolan@va.gov;
   cstappen@uw.edu; Samantha.Yard@va.gov; Tracy.Simpson@va.gov;
   Karin.Nelson@va.gov
RI Campbell, Sarah/ITT-4766-2023
FU VA Puget Sound Healthcare System (VAPS); VAPS Mental Illness Research,
   Education, and Clinical Center; VAPS Health Services Research and
   Development (HSR&D) Center of Excellence; VA HSR&D Career Development
   Award [2015-2020] [CDA 12-263]; HSR&D OAA fellowship [TPH 61-000-23]
FX This work was supported by resources from VA Puget Sound Healthcare
   System (VAPS), and local funds from VAPS Mental Illness Research,
   Education, and Clinical Center and VAPS Health Services Research and
   Development (HSR&D) Center of Excellence. The first author is supported
   by a VA HSR&D Career Development Award [CDA 12-263; 2015-2020]. The
   second author is supported by an HSR&D OAA fellowship [TPH 61-000-23].
   Sponsors did not play any role in the study design; collection, analysis
   and interpretation of data; the writing of the report; or decision to
   submit the article for publication.
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NR 65
TC 39
Z9 48
U1 1
U2 8
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
EI 2211-3355
J9 PREV MED REP
JI Prev. Med. Rep.
PD SEP
PY 2019
VL 15
AR 100930
DI 10.1016/j.pmedr.2019.100930
PG 7
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA VJ9EF
UT WOS:000645518700047
PM 31338278
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Scheewe, TW
   Backx, FJG
   Takken, T
   Jörg, F
   van Strater, ACP
   Kroes, AG
   Kahn, RS
   Cahn, W
AF Scheewe, T. W.
   Backx, F. J. G.
   Takken, T.
   Jorg, F.
   van Strater, A. C. P.
   Kroes, A. G.
   Kahn, R. S.
   Cahn, W.
TI Exercise therapy improves mental and physical health in schizophrenia: a
   randomised controlled trial
SO ACTA PSYCHIATRICA SCANDINAVICA
LA English
DT Article
DE mental health; physical health; need of care; cardiovascular fitness;
   metabolic syndrome
ID NEGATIVE-SYNDROME-SCALE; MOTIVATIONAL INTERVENTION; SYMPTOMS; PEOPLE;
   RISK; RELIABILITY; INSTRUMENT; MANAGEMENT; OLANZAPINE; STATEMENT
AB Objective The objective of this multicenter randomised clinical trial was to examine the effect of exercise versus occupational therapy on mental and physical health in schizophrenia patients. Method Sixty-three patients with schizophrenia were randomly assigned to 2h of structured exercise (n=31) or occupational therapy (n=32) weekly for 6months. Symptoms (Positive and Negative Syndrome Scale) and cardiovascular fitness levels (Wpeak and VO2peak), as assessed with a cardiopulmonary exercise test, were the primary outcome measures. Secondary outcome measures were the Montgomery and angstrom sberg Depression Rating Scale, Camberwell Assessment of Needs, body mass index, body fat percentage, and metabolic syndrome (MetS). Results Intention-to-treat analyses showed exercise therapy had a trend-level effect on depressive symptoms (P=0.07) and a significant effect on cardiovascular fitness, measured by Wpeak (P<0.01), compared with occupational therapy. Per protocol analyses showed that exercise therapy reduced symptoms of schizophrenia (P=0.001), depression (P=0.012), need of care (P=0.050), and increased cardiovascular fitness (P<0.001) compared with occupational therapy. No effect for MetS (factors) was found except a trend reduction in triglycerides (P=0.08). Conclusion Exercise therapy, when performed once to twice a week, improved mental health and cardiovascular fitness and reduced need of care in patients with schizophrenia.
C1 [Scheewe, T. W.; Kroes, A. G.; Kahn, R. S.; Cahn, W.] Univ Med Ctr Utrecht, Dept Psychiat, Rudolf Magnus Inst Neurosci, NL-3584 CX Utrecht, Netherlands.
   [Backx, F. J. G.] Univ Med Ctr Utrecht, Dept Rehabil Nursing Sci & Sports, Rudolf Magnus Inst Neurosci, NL-3584 CX Utrecht, Netherlands.
   [Takken, T.] Univ Med Ctr Utrecht, Wilhelmina Childrens Hosp, Child Dev & Exercise Ctr, NL-3584 CX Utrecht, Netherlands.
   [Jorg, F.] GGZ Friesland, Leeuwarden, Netherlands.
   [van Strater, A. C. P.] GGZ Duin En Bollenstreek, Voorhout, Netherlands.
   [Kroes, A. G.] Julius Clin Res, Zeist, Netherlands.
C3 Utrecht University; Utrecht University Medical Center; Utrecht
   University; Utrecht University Medical Center; Wilhelmina
   Kinderziekenhuis; Utrecht University; Utrecht University Medical Center
RP Scheewe, TW (corresponding author), Univ Med Ctr Utrecht, Dept Psychiat, A00-241,Heidelberglaan 100, NL-3584 CX Utrecht, Netherlands.
EM tscheewe@umcutrecht.nl
RI Takken, Tim/A-9912-2010; Cahn, W/B-5743-2013
OI Takken, Tim/0000-0002-7737-118X
FU Eli Lilly; BMS; Lundbeck; Sanofi-Aventis; Janssen-Cilag; Astra-Zeneca;
   Schering-Plough
FX Dr. W. Cahn is or has been an unrestricted research grant holder with,
   or has received financial compensation as an independent symposium
   speaker, or as an consultant from, Eli Lilly, BMS, Lundbeck,
   Sanofi-Aventis, Janssen-Cilag, Astra-Zeneca and Schering-Plough. All
   other authors have declared that there are no conflicts of interest in
   relation to the subject of this study.
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NR 56
TC 172
Z9 194
U1 1
U2 78
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0001-690X
EI 1600-0447
J9 ACTA PSYCHIAT SCAND
JI Acta Psychiatr. Scand.
PD JUN
PY 2013
VL 127
IS 6
BP 464
EP 473
DI 10.1111/acps.12029
PG 10
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 141AO
UT WOS:000318697900009
PM 23106093
DA 2025-06-11
ER

PT J
AU Lockhart, G
   MacKinnon, DP
   Ohlrich, V
AF Lockhart, Ginger
   MacKinnon, David P.
   Ohlrich, Vanessa
TI Mediation Analysis in Psychosomatic Medicine Research
SO PSYCHOSOMATIC MEDICINE
LA English
DT Article
DE statistical mediation; mediation analysis; mechanism; indirect effect
ID BEHAVIORAL STRESS-MANAGEMENT; ARTERY RISK DEVELOPMENT;
   SOCIOECONOMIC-STATUS; SOCIAL SUPPORT; BLOOD-PRESSURE; YOUNG-ADULTS;
   EDUCATIONAL-ATTAINMENT; PSYCHOLOGICAL STRESS; METABOLIC SYNDROME;
   LONGITUDINAL DATA
AB This article presents an overview of statistical mediation analysis and its application to psychosomatic medicine research. The article begins with a description of the major approaches to mediation analysis and an evaluation of the strengths and limits of each. Emphasis is placed on longitudinal mediation models, and an application using latent growth modeling is presented. The article concludes with a description of recent developments in mediation analysis and suggestions for the use of mediation for future work in psychosomatic medicine research.
C1 [Lockhart, Ginger] Arizona State Univ, Dept Psychol, Res Prevent Lab, Tempe, AZ 85287 USA.
C3 Arizona State University; Arizona State University-Tempe
RP Lockhart, G (corresponding author), Arizona State Univ, Dept Psychol, Res Prevent Lab, POB 871104, Tempe, AZ 85287 USA.
EM ginger.lockhart@asu.edu
RI MacKinnon, David/D-8727-2013
OI MacKinnon, David/0000-0003-0866-6010
FU National Institute of Drug Abuse [R01DA009757-09]; National Institute of
   Mental Health [P30 MH066247]
FX This work was supported by the National Institute of Drug Abuse
   (R01DA009757-09; MacKinnon) and the National Institute of Mental Health
   (P30 MH066247; Lockhart).
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NR 139
TC 76
Z9 85
U1 4
U2 40
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0033-3174
EI 1534-7796
J9 PSYCHOSOM MED
JI Psychosom. Med.
PD JAN
PY 2011
VL 73
IS 1
BP 29
EP 43
DI 10.1097/PSY.0b013e318200a54b
PG 15
WC Psychiatry; Psychology; Psychology, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry; Psychology
GA 711BZ
UT WOS:000286562000005
PM 21148809
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Slavich, GM
   Irwin, MR
AF Slavich, George M.
   Irwin, Michael R.
TI From Stress to Inflammation and Major Depressive Disorder: A Social
   Signal Transduction Theory of Depression
SO PSYCHOLOGICAL BULLETIN
LA English
DT Article
DE early life stress; social threat; cytokines; mechanisms; disease
ID C-REACTIVE PROTEIN; TO-BRAIN COMMUNICATION; CORONARY-HEART-DISEASE;
   EARLY-LIFE STRESS; ARTERY RISK DEVELOPMENT; NF-KAPPA-B; PROINFLAMMATORY
   CYTOKINE PRODUCTION; INTERCELLULAR-ADHESION MOLECULE-1; EXCESSIVE
   REASSURANCE SEEKING; ADVERSE CHILDHOOD EXPERIENCES
AB Major life stressors, especially those involving interpersonal stress and social rejection, are among the strongest proximal risk factors for depression. In this review, we propose a biologically plausible, multilevel theory that describes neural, physiologic, molecular, and genomic mechanisms that link experiences of social-environmental stress with internal biological processes that drive depression pathogenesis. Central to this social signal transduction theory of depression is the hypothesis that experiences of social threat and adversity up-regulate components of the immune system involved in inflammation. The key mediators of this response, called proinflammatory cytokines, can in turn elicit profound changes in behavior, which include the initiation of depressive symptoms such as sad mood, anhedonia, fatigue, psychomotor retardation, and social-behavioral withdrawal. This highly conserved biological response to adversity is critical for survival during times of actual physical threat or injury. However, this response can also be activated by modern-day social, symbolic, or imagined threats, leading to an increasingly proinflammatory phenotype that may be a key phenomenon driving depression pathogenesis and recurrence, as well as the overlap of depression with several somatic conditions including asthma, rheumatoid arthritis, chronic pain, metabolic syndrome, cardiovascular disease, obesity, and neurodegeneration. Insights from this theory may thus shed light on several important questions including how depression develops, why it frequently recurs, why it is strongly predicted by early life stress, and why it often co-occurs with symptoms of anxiety and with certain physical disease conditions. This work may also suggest new opportunities for preventing and treating depression by targeting inflammation.
C1 [Slavich, George M.; Irwin, Michael R.] Univ Calif Los Angeles, Cousins Ctr Psychoneuroimmunol, Los Angeles, CA 90095 USA.
   [Slavich, George M.; Irwin, Michael R.] Univ Calif Los Angeles, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90095 USA.
C3 University of California System; University of California Los Angeles;
   University of California System; University of California Los Angeles
RP Slavich, GM (corresponding author), Univ Calif Los Angeles, Cousins Ctr Psychoneuroimmunol, UCLA Med Plaza 300,Room 3156, Los Angeles, CA 90095 USA.
EM gslavich@mednet.ucla.edu
RI Slavich, George/C-6208-2008; Irwin, Michael/H-4870-2013
OI Irwin, Michael/0000-0002-1502-8431
FU National Institutes of Health (NIH) [R01 CA140933]; Society in
   Science-Branco Weiss Fellowship; NIH [R01 AG034588, R01 AG026364, R01
   CA160245, R01 CA119159, R01 HL095799, R01 DA032922, P30 AG028748]; UCLA
   Clinical and Translational Science Institute [UL1 TR000124]; Cousins
   Center for Psychoneuroimmunology
FX George M. Slavich and Michael R. Irwin, Cousins Center for
   Psychoneuroimmunology and Department of Psychiatry and Biobehavioral
   Sciences, University of California, Los Angeles. Preparation of this
   review was supported by National Institutes of Health (NIH) Grant R01
   CA140933 and by a Society in Science-Branco Weiss Fellowship to George
   M. Slavich; by NIH Grants R01 AG034588, R01 AG026364, R01 CA160245, R01
   CA119159, R01 HL095799, R01 DA032922, and P30 AG028748 to Michael R.
   Irwin; and by seed grants from the UCLA Clinical and Translational
   Science Institute (UL1 TR000124) and the Cousins Center for
   Psychoneuroimmunology. We thank Keely Muscatell and Aoife O'Donovan for
   their very helpful comments on a previous version of the manuscript.
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NR 489
TC 1427
Z9 1630
U1 34
U2 675
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 0033-2909
EI 1939-1455
J9 PSYCHOL BULL
JI Psychol. Bull.
PD MAY
PY 2014
VL 140
IS 3
BP 774
EP 815
DI 10.1037/a0035302
PG 42
WC Psychology; Psychology, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology
GA AG2CZ
UT WOS:000335224800007
PM 24417575
OA Green Accepted, Green Published
DA 2025-06-11
ER

PT J
AU Manczak, EM
   Gotlib, IH
AF Manczak, Erika M.
   Gotlib, Ian H.
TI Lipid Profiles at Birth Predict Teacher-Rated Child Emotional and Social
   Development 5 Years Later
SO PSYCHOLOGICAL SCIENCE
LA English
DT Article
DE fetal development; cholesterol; triglycerides; emotion regulation;
   psychological health
ID DENSITY-LIPOPROTEIN CHOLESTEROL; METABOLIC SYNDROME; FETAL EXPOSURE;
   HEALTH; RISK; DEPRESSION; PREGNANCY; DISEASE; COHORT; LEVEL
AB The fetal environment has been increasingly implicated in later psychological health, but the role of lipids is unknown. Drawing on the ethnically diverse Born in Bradford (BiB) birth cohort, the current study related levels of high-density lipoprotein (HDL), very-low-density lipoprotein (VLDL), and triglycerides in umbilical cord blood to 1,369 children's teacher-rated psychosocial competence approximately 5 years later. Results of ordinal logistic regressions indicated that low levels of HDL, high levels of VLDL, and high levels of triglycerides predicted greater likelihood of being rated as less competent in domains of emotion regulation, self-awareness, and interpersonal functioning. Furthermore, these results generalized across ethnic background and children's sex and were not accounted for by variables reflecting mothers' psychological or physical health, children's physical health, or children's special education status. Together, these results identify fetal exposure to anomalous lipid levels as a possible contributor to subsequent psychological health and social functioning.
C1 [Manczak, Erika M.] Univ Denver, Dept Psychol, 2155 S Race St, Denver, CO 80202 USA.
   [Gotlib, Ian H.] Stanford Univ, Dept Psychol, Stanford, CA 94305 USA.
C3 University of Denver; Stanford University
RP Manczak, EM (corresponding author), Univ Denver, Dept Psychol, 2155 S Race St, Denver, CO 80202 USA.
EM erika.manczak@du.edu
FU National Institute of Mental Health [R37-MH101495, MH019938]; Wellcome
   Trust [101597/Z/13/Z]; Wellcome Trust [101597/Z/13/Z] Funding Source:
   Wellcome Trust
FX This research was supported by National Institute of Mental Health
   Grants R37-MH101495 (to I. H. Gotlib) and MH019938 (funding E. M.
   Manczak). Born in Bradford receives biomedical resources infrastructure
   funding from the Wellcome Trust (101597/Z/13/Z).
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NR 41
TC 7
Z9 8
U1 2
U2 11
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0956-7976
EI 1467-9280
J9 PSYCHOL SCI
JI Psychol. Sci.
PD DEC
PY 2019
VL 30
IS 12
BP 1780
EP 1789
AR 0956797619885649
DI 10.1177/0956797619885649
EA NOV 2019
PG 10
WC Psychology, Multidisciplinary
WE Social Science Citation Index (SSCI)
SC Psychology
GA JV1QN
UT WOS:000497077700001
PM 31710576
OA Green Published
DA 2025-06-11
ER

PT J
AU Human, LJ
   Biesanz, JC
   Miller, GE
   Chen, E
   Lachman, ME
   Seeman, TE
AF Human, Lauren J.
   Biesanz, Jeremy C.
   Miller, Gregory E.
   Chen, Edith
   Lachman, Margie E.
   Seeman, Teresa E.
TI Is hCange Bad? Personality Change Is Associated with Poorer
   Psychological Health and Greater Metabolic Syndrome in Midlife
SO JOURNAL OF PERSONALITY
LA English
DT Article
ID TRAITS; CHILDHOOD; RISK; PREDICTORS; MORTALITY; RESILIENCE; MECHANISMS;
   DEPRESSION; HOSTILITY; PATHWAYS
AB Personality change is emerging as an important predictor of health and well-being. Extending previous research, we examined whether two types of personality change, directional and absolute, are associated with both subjective and objective indicators of health. Utilizing the longitudinal Midlife in the United States survey (MIDUS) data, we examined whether both types of change over 10 years were associated with psychological well-being, self-reported global health, and the presence of metabolic syndrome (MetS) components and diagnosis. Socially undesirable personality change (e.g., becoming less conscientious and more neurotic) and absolute personality change were independently associated with worse perceived health and well-being at Time 2. Notably, absolute personality change, regardless of the direction, was also associated with having a greater number of MetS components and a greater probability of diagnosis at Time 2. In sum, too much personality change may be bad for one's health: Socially undesirable and absolute personality change were both associated with worse psychological health and worse metabolic profiles over 10 years. These findings suggest that personality change may contribute to psychological and physical health, and provide initial insight into potential intermediate links between personality change and distal outcomes such as mortality.
C1 [Human, Lauren J.; Biesanz, Jeremy C.] Univ British Columbia, Vancouver, BC V6T 1Z4, Canada.
   [Miller, Gregory E.; Chen, Edith] Northwestern Univ, Evanston, IL 60208 USA.
   [Lachman, Margie E.] Brandeis Univ, Waltham, MA 02254 USA.
   [Seeman, Teresa E.] Univ Calif Los Angeles, Los Angeles, CA USA.
C3 University of British Columbia; Northwestern University; Brandeis
   University; University of California System; University of California
   Los Angeles
RP Human, LJ (corresponding author), Univ British Columbia, Dept Psychol, 2136 West Mall, Vancouver, BC V6T 1Z4, Canada.
EM lhuman@psych.ubc.ca
OI Miller, Gregory/0000-0002-7217-1082; Lachman, Margie/0000-0003-3027-8735
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NR 41
TC 58
Z9 63
U1 0
U2 21
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-3506
EI 1467-6494
J9 J PERS
JI J. Pers.
PD JUN
PY 2013
VL 81
IS 3
BP 249
EP 260
DI 10.1111/jopy.12002
PG 12
WC Psychology, Social
WE Social Science Citation Index (SSCI)
SC Psychology
GA 144OU
UT WOS:000318950100002
PM 22924900
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Poursafa, P
   Kamali, Z
   Fraszczyk, E
   Boezen, HM
   Vaez, A
   Snieder, H
AF Poursafa, Parinaz
   Kamali, Zoha
   Fraszczyk, Eliza
   Boezen, H. Marike
   Vaez, Ahmad
   Snieder, Harold
TI DNA methylation: a potential mediator between air pollution and
   metabolic syndrome
SO CLINICAL EPIGENETICS
LA English
DT Review
DE Epigenetics; DNA methylation; Metabolic syndrome; Air pollution
ID POLYCYCLIC AROMATIC-HYDROCARBONS; EPIGENOME-WIDE ASSOCIATION; FINE
   PARTICULATE MATTER; CARDIOMETABOLIC RISK-FACTORS; GENE-SPECIFIC
   METHYLATION; OXIDATIVE STRESS; ENDOTHELIAL DYSFUNCTION;
   ENVIRONMENTAL-FACTORS; PROMOTER METHYLATION; INSULIN-RESISTANCE
AB Given the global increase in air pollution and its crucial role in human health, as well as the steep rise in prevalence of metabolic syndrome (MetS), a better understanding of the underlying mechanisms by which environmental pollution may influence MetS is imperative. Exposure to air pollution is known to impact DNA methylation, which in turn may affect human health. This paper comprehensively reviews the evidence for the hypothesis that the effect of air pollution on the MetS is mediated by DNA methylation in blood. First, we present a summary of the impact of air pollution on metabolic dysregulation, including the components of MetS, i.e., disorders in blood glucose, lipid profile, blood pressure, and obesity. Then, we provide evidence on the relation between air pollution and endothelial dysfunction as one possible mechanism underlying the relation between air pollution and MetS. Subsequently, we review the evidence that air pollution (PM, ozone, NO2 and PAHs) influences DNA methylation. Finally, we summarize association studies between DNA methylation and MetS. Integration of current evidence supports our hypothesis that methylation may partly mediate the effect of air pollution on MetS.
C1 [Poursafa, Parinaz; Kamali, Zoha; Fraszczyk, Eliza; Boezen, H. Marike; Vaez, Ahmad; Snieder, Harold] Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, Groningen, Netherlands.
   [Kamali, Zoha; Vaez, Ahmad] Isfahan Univ Med Sci, Dept Bioinformat, Esfahan, Iran.
C3 University of Groningen; Isfahan University of Medical Sciences
RP Vaez, A; Snieder, H (corresponding author), Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, Groningen, Netherlands.
EM a.vaez@umcg.nl; h.snieder@umcg.nl
RI Vaez, Ahmad/B-4336-2018; poursafa, parinaz/U-2924-2017; Fraszczyk,
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OI Fraszczyk, Eliza/0000-0002-2163-1560; Kamali, Zoha/0000-0001-6492-5887
FU Isfahan University of Medical Sciences, Isfahan, Iran
FX ZK and AV are financially supported by Isfahan University of Medical
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NR 141
TC 32
Z9 36
U1 6
U2 44
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1868-7075
EI 1868-7083
J9 CLIN EPIGENETICS
JI Clin. Epigenetics
PD DEC
PY 2022
VL 14
IS 1
AR 82
DI 10.1186/s13148-022-01301-y
PG 13
WC Oncology; Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Genetics & Heredity
GA 2O9YQ
UT WOS:000819407800001
PM 35773726
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Jeon, SW
   Lim, SW
   Shin, DW
   Ryu, S
   Chang, Y
   Kim, SY
   Oh, KS
   Shin, YC
   Kim, YH
AF Jeon, Sang Won
   Lim, Se-Won
   Shin, Dong-Won
   Ryu, Seungho
   Chang, Yoosoo
   Kim, Sun-Young
   Oh, Kang-Seob
   Shin, Young-Chul
   Kim, Young Hwan
TI Metabolic syndrome and incident depressive symptoms in young and
   middle-aged adults: A cohort study
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Depression; Depressive symptoms; Metabolic syndrome; Obesity; Cohort
   study
ID CORONARY-HEART-DISEASE; CARDIOVASCULAR-DISEASE; DIABETES-MELLITUS;
   ASSOCIATION; RISK; ANXIETY; OBESITY; PREVALENCE; MANAGEMENT; MORTALITY
AB Background: : Recent studies on the prospective association between metabolic syndrome (MetS) and depression have reported conflicting findings.
   Methods: : A cohort study was performed with 115,223 middle-aged adults, free of depression at baseline, who underwent at least 2 comprehensive exams between 2012 and 2015. MetS was assessed according to the National Cholesterol Education Program Adult Treatment Panel III. The study endpoint was new onset of depression, defined as a Center for Epidemiologic Studies-Depression Scale score >= 16.
   Results: : Over 253,451.6 person-years, 6,833 participants developed depression. When the participants with 0 MetS components were set as a reference, the multivariable-adjusted hazard ratio (HR, 95% confidence interval [CI]) for incident depression formed a U-shaped curve with the number of MetS components (p for trend = 0.229): 1 (1.07 [1.02-1.15]); 2 (0.92 [0.82-1.06]); 3 (0.85 [0.78-1.07]); 4 (1.16 [1.06-1.32]); and 5 MetS components (1.25 [1.10-1.54]). The presence or absence of MetS was not significant in new-onset depression. In examining potential clustering and synergistic effects of the constituent parts, waist circumference was the major driving factor of incident depression, and its relative excess risk due to interaction increased with the number of combinations.
   Limitations: : We used a self-reported depression scale, and the follow-up period was relatively short.
   Conclusions: : Future studies investigating the risk for incident depression should place more focus on the number of MetS abnormalities and specific MetS factors, such as waist circumference, than the presence or absence of MetS.
C1 [Jeon, Sang Won; Lim, Se-Won; Shin, Dong-Won; Kim, Sun-Young; Oh, Kang-Seob; Shin, Young-Chul] Sungkyunkwan Univ, Sch Med, Kangbuk Samsung Hosp, Dept Psychiat, 29 Saemunan Ro, Seoul 03181, South Korea.
   [Lim, Se-Won; Shin, Young-Chul] Kangbuk Samsung Hosp, Workpl Mental Hlth Inst, Seoul, South Korea.
   [Ryu, Seungho; Chang, Yoosoo] Kangbuk Samsung Hosp, Total Healthcare Ctr, Ctr Cohort Study, Seoul, South Korea.
   [Ryu, Seungho; Chang, Yoosoo] Sungkyunkwan Univ, Sch Med, Kangbuk Samsung Hosp, Dept Occupat & Environm Med, Seoul, South Korea.
   [Kim, Young Hwan] Sungkyunkwan Univ, Sch Med, Kangbuk Samsung Hosp, Dept Nucl Med, Seoul, South Korea.
C3 Sungkyunkwan University (SKKU); Sungkyunkwan University (SKKU); Samsung
   Medical Center; Sungkyunkwan University (SKKU); Samsung Medical Center;
   Sungkyunkwan University (SKKU); Samsung Medical Center; Sungkyunkwan
   University (SKKU); Samsung Medical Center
RP Lim, SW; Shin, DW (corresponding author), Sungkyunkwan Univ, Sch Med, Kangbuk Samsung Hosp, Dept Psychiat, 29 Saemunan Ro, Seoul 03181, South Korea.
EM healthysewon@daum.net; ntour@unitel.co.kr
RI Shin, Dong/F-5366-2010; Kim, Hyo Yeol/HLP-5150-2023
OI Kim, Young Hwan/0000-0002-6513-3846; Chang, Yoosoo/0000-0002-6945-9050;
   Ryu, Seungho/0000-0002-3927-8646
FU Korea Health Technology R&D Project through the Korea Health Industry
   Development Institute (KHIDI) - Ministry of Health & Welfare, Republic
   of Korea [HC15C1405]
FX This research was supported by a grant of the Korea Health Technology
   R&D Project through the Korea Health Industry Development Institute
   (KHIDI), funded by the Ministry of Health & Welfare, Republic of
   Korea(grant number: HC15C1405).
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PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD MAR 1
PY 2019
VL 246
BP 643
EP 651
DI 10.1016/j.jad.2018.12.073
PG 9
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA HJ6EE
UT WOS:000457276200078
PM 30611062
DA 2025-06-11
ER

PT J
AU Luévano-Contreras, C
   Gómez-Ojeda, A
   Macías-Cervantes, MH
   Garay-Sevilla, ME
AF Luevano-Contreras, Claudia
   Gomez-Ojeda, Armando
   Habacuc Macias-Cervantes, Maciste
   Eugenia Garay-Sevilla, Ma
TI Dietary Advanced Glycation End Products and Cardiometabolic Risk
SO CURRENT DIABETES REPORTS
LA English
DT Review
DE Cardiometabolic risk; Advanced glycation end product; Maillard reaction;
   N-epsilon-(carboxymethyl)-lysine; Dietary AGEs
ID HEALTHY OVERWEIGHT INDIVIDUALS; RANDOMIZED CONTROLLED-TRIAL; TYPE-2
   DIABETES-MELLITUS; RENAL-FAILURE PATIENTS; OXIDATIVE STRESS; ENDOTHELIAL
   FUNCTION; INSULIN-RESISTANCE; CARDIOVASCULAR-DISEASE; METABOLIC
   SYNDROME; MAILLARD REACTION
AB Purpose of Review This report analyzes emerging evidence about the role of dietary advanced glycation end products (AGEs) as a cardiometabolic risk factor. Two important aspects are discussed: First, the modulation of AGE load by dietary AGEs; second, if the evidence of clinical and observational studies is enough to make dietary recommendations towards lowering AGE intake.
   Recent Findings Clinical studies in subjects with diabetes mellitus have shown that high intake of dietary AGEs increases inflammation markers, oxidative stress, and could impair endothelial function. In subjects at risk for cardiometabolic diseases (with overweight, obesity, or prediabetes), dietary AGE restriction decreases some inflammatory molecules and improves insulin sensitivity. However, studies in healthy subjects are limited, and not all of the studies have shown a decrease in circulating AGEs. Therefore, it is still unclear if dietary AGEs represent a health concern for people potentially at risk for cardiometabolic diseases.
   Summary The evidence shows that dietary AGEs are bioavailable and absorbed, and the rate of excretion depends on dietary intake. The metabolic fate of most dietary AGEs remains unknown. Regardless, most studies have shown that by diminishing AGE intake, circulating levels will also decrease. Thus, dietary AGEs can modulate the AGE load at least in patients with DM, overweight, or obesity. Studies with specific clinical outcomes and large-scale observational studies are needed for a better risk assessment of dietary AGEs and to establish dietary recommendations accordingly.
C1 [Luevano-Contreras, Claudia; Gomez-Ojeda, Armando; Habacuc Macias-Cervantes, Maciste; Eugenia Garay-Sevilla, Ma] Univ Guanajuato, Dept Med Sci, 20 Enero 929, Guanajuato, Mexico.
C3 Universidad de Guanajuato
RP Luévano-Contreras, C (corresponding author), Univ Guanajuato, Dept Med Sci, 20 Enero 929, Guanajuato, Mexico.
EM c.luevanocontreras@ugto.mx
RI Luevano-Contreras, Claudia/ADJ-1806-2022
OI GOMEZ-OJEDA, ARMANDO/0009-0005-3711-8605; Luevano-Contreras,
   Claudia/0000-0002-2632-8093
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NR 104
TC 54
Z9 59
U1 1
U2 47
PU CURRENT MEDICINE GROUP
PI PHILADELPHIA
PA 400 MARKET STREET, STE 700, PHILADELPHIA, PA 19106 USA
SN 1534-4827
EI 1539-0829
J9 CURR DIABETES REP
JI Curr. Diabetes Rep.
PD AUG
PY 2017
VL 17
IS 8
AR 63
DI 10.1007/s11892-017-0891-2
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA FA5GW
UT WOS:000405472100009
PM 28695383
DA 2025-06-11
ER

PT J
AU Smith, J
   Ferguson, D
   Jauregui, G
   Panarace, M
   Medina, M
   Lehnert, S
   Hill, JR
AF Smith, Jennifer
   Ferguson, Drewe
   Jauregui, Guillermo
   Panarace, Martin
   Medina, Mariano
   Lehnert, Sigrid
   Hill, Jonathan R.
TI Short-term maternal psychological stress in the post-conception period
   in ewes affects fetal growth and gestation length
SO REPRODUCTION
LA English
DT Article
ID PRENATAL STRESS; PERICONCEPTIONAL PERIOD; METABOLIC SYNDROME;
   BODY-WEIGHT; PROGESTERONE; EMBRYO; SHEEP; NUTRITION; PREGNANCY;
   SUPEROVULATION
AB Fetal development can be influenced by maternal environment in the peri-conceptional period. This study investigated the effect of maternal feed intake and psychological stress within the first 6 days after conception on embryo development and fetal growth. Superovulated ewes (n=40) were artificially inseminated with semen from one ram. Ewes were then divided into four groups (n=10): group 1 (control) was fed at maintenance level, group 2 (high) at 2 x maintenance, and group 3 (low) at 0.5 x maintenance on days 2-6 after conception. Group 4 (stress) was fed at maintenance level and then an intense physical and psychological stress challenge was applied for 1 h only on days 2 and 3 after conception. Embryos were recovered at day 6. A total of 113 transferable grade embryos were transferred singly into synchronized untreated recipients, while the remaining embryos (n=165) were fixed and stained for cell counts. Post-conception maternal stress or feed intake did not alter the cell count or grade of day 6 embryos. Fetuses from the stress group had longer crown-rump lengths at day 30 and longer femur length at day 58. Fetuses from the stressed and high feed groups had greater abdominal circumferences at day 85. Subsequent birth weights were not significantly different. Ewes carrying lambs from the stress treatment had shorter gestation lengths. These results show that short-term perturbations of the post-conception maternal environment have measurable effects on fetal development and gestation length.
C1 [Smith, Jennifer; Ferguson, Drewe; Hill, Jonathan R.] CSIRO Livestock Ind, FD McMaster Lab, Armidale, NSW 2350, Australia.
   [Jauregui, Guillermo; Panarace, Martin; Medina, Mariano] Goyaike SAACI & F Biotecnol Anim, RA-6725 Buenos Aires, DF, Argentina.
   [Lehnert, Sigrid] CSIRO Livestock Ind, Queensland Biotechnol Precinct, St Lucia, Qld 4067, Australia.
C3 Commonwealth Scientific & Industrial Research Organisation (CSIRO);
   Commonwealth Scientific & Industrial Research Organisation (CSIRO)
RP Hill, JR (corresponding author), Univ Queensland, St Lucia, Qld 4072, Australia.
EM jonathan.hill@uq.edu.au
RI Hill, Jonathan/AAF-7501-2021; Ferguson, Drewe/E-8342-2011; Lehnert,
   Sigrid/A-3676-2013
OI Hill, Jonathan/0000-0001-7640-0463; Lehnert, Sigrid/0000-0003-4891-9094
FU Goyaike SAACI y F Biotecnologia Animal, Buenos Aires, Argentina,; CSIRO
   Livestock Industries, Brisbane, Australia
FX This work was supported by funding front Goyaike SAACI y F Biotecnologia
   Animal, Buenos Aires, Argentina, and CSIRO Livestock Industries,
   Brisbane, Australia.
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NR 32
TC 13
Z9 15
U1 0
U2 10
PU BIOSCIENTIFICA LTD
PI BRISTOL
PA STARLING HOUSE, 1600 BRISTOL PARKWAY N, BRISTOL, ENGLAND
SN 1470-1626
J9 REPRODUCTION
JI Reproduction
PD AUG
PY 2008
VL 136
IS 2
BP 259
EP 265
DI 10.1530/REP-07-0400
PG 7
WC Developmental Biology; Reproductive Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Developmental Biology; Reproductive Biology
GA 340UW
UT WOS:000258671500013
PM 18469037
OA Bronze
DA 2025-06-11
ER

PT J
AU dos Santos, A
   Galiè, S
AF dos Santos, Adriano
   Galie, Serena
TI The Microbiota-Gut-Brain Axis in Metabolic Syndrome and Sleep Disorders:
   A Systematic Review
SO NUTRIENTS
LA English
DT Review
DE dysbiosis; gut microbiome; microbiome metabolites; metabolic syndrome;
   sleep quality; sleep efficiency
ID CARDIOMETABOLIC RISK-FACTORS; MEDITERRANEAN DIET; HEALTHY-INDIVIDUALS;
   CIRCADIAN-RHYTHMS; OXIDATIVE STRESS; QUALITY INDEX; INFLAMMATION;
   INTERVENTION; CLOCK; METAANALYSIS
AB Background: Over recent decades, a growing body of evidence has emerged linking the composition of the gut microbiota to sleep regulation. Interestingly, the prevalence of sleep disorders is commonly related to cardiometabolic comorbidities such as diabetes, impaired lipid metabolism, and metabolic syndrome (MetS). In this complex scenario, the role of the gut-brain axis as the main communicating pathway between gut microbiota and sleep regulation pathways in the brain reveals some common host-microbial biomarkers in both sleep disturbances and MetS. As the biological mechanisms behind this complex interacting network of neuroendocrine, immune, and metabolic pathways are not fully understood yet, the present systematic review aims to describe common microbial features between these two unrelated chronic conditions. Results: This systematic review highlights a total of 36 articles associating the gut microbial signature with MetS or sleep disorders. Specific emphasis is given to studies evaluating the effect of dietary patterns, dietary supplementation, and probiotics on MetS or sleep disturbances. Conclusions: Dietary choices promote microbial composition and metabolites, causing both the amelioration and impairment of MetS and sleep homeostasis.
C1 [dos Santos, Adriano] Integrat Med Nutr Dept, ADS Vital BV, NL-2517 AS The Hague, Netherlands.
   [Galie, Serena] European Inst Oncol IRCCS, Dept Expt Oncol, I-20139 Milan, Italy.
C3 IRCCS European Institute of Oncology (IEO)
RP dos Santos, A (corresponding author), Integrat Med Nutr Dept, ADS Vital BV, NL-2517 AS The Hague, Netherlands.
EM adriano.dossantos@students.unibe.ch; serena.galie@ieo.it
RI Santos, Adriano/ABH-6885-2020; Galié, Serena/AAC-6861-2022
OI dos Santos, Adriano/0009-0002-5069-076X; Galie,
   Serena/0000-0003-4431-3140
FU Integrative Medicine Nutrition Department, ADS Vitality B.V.; ADS
   Vitality Integrative Medicine Nutrition Centre; Royal Society of
   Medicine
FX This work was supported by the ADS Vitality Integrative Medicine
   Nutrition Centre. An external librarian, Beata Coffey, from The Royal
   Society of Medicine, provided the literature search and first screening
   process. A.D.S., an expert in nutrition and sleep disturbances, and
   S.G., an expert in nutrition and gut microbiota, were independently
   involved in the quality assessment of the selected articles. A.D.S. was
   involved in the design, drafting, and editing procedures of the
   manuscript.
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NR 109
TC 16
Z9 16
U1 12
U2 21
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD FEB
PY 2024
VL 16
IS 3
AR 390
DI 10.3390/nu16030390
PG 24
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA HM7M6
UT WOS:001159988000001
PM 38337675
OA gold
DA 2025-06-11
ER

PT J
AU Rhon, DI
   Greenlee, TA
   Marchant, BG
   Sissel, CD
   Cook, CE
AF Rhon, Daniel, I
   Greenlee, Tina A.
   Marchant, Bryant G.
   Sissel, Charles Dennis
   Cook, Chad E.
TI Comorbidities in the first 2 years after arthroscopic hip surgery:
   substantial increases in mental health disorders, chronic pain,
   substance abuse and cardiometabolic conditions
SO BRITISH JOURNAL OF SPORTS MEDICINE
LA English
DT Article
ID PHYSICAL-ACTIVITY; FEMOROACETABULAR IMPINGEMENT; METABOLIC SYNDROME;
   SLEEP DISTURBANCE; MORTALITY; EXERCISE; COMPLICATIONS; RISK; CARE;
   EPIDEMIOLOGY
AB Objectives We aimed to identify the rate of seven comorbidities (mental health disorders, chronic pain, substance abuse disorders, cardiovascular disorders, metabolic syndrome, systemic arthropathy and sleep disorders) that occurred within 2 years after hip arthroscopy.
   Methods Data from individuals (ages 18-50 years) undergoing arthroscopic hip surgery between 2004 and 2013 were collected from the Military Health System (MHS) Data Repository (MDR). The MDR captures all healthcare encounters in all settings and locations for individuals within the MHS. Person-level data over 36 months were pulled and aggregated. Seven comorbidities related to poor outcomes from musculoskeletal disorders (mental health disorders, chronic pain, substance abuse disorders, cardiovascular disorders, metabolic syndrome, systemic arthropathy and sleep disorders) were examined 12 months prior and 24 months after surgery. Changes in frequencies were calculated as were differences in proportions between presurgery and postsurgery.
   Results 1870 subjects were identified (mean age 32.24 years; 55.5% men) and analysed. There were statistically significant increases (p<0.001) proportionally for all comorbidities after surgery. Relative to baseline, cases of mental health disorders rose 84%, chronic pain diagnoses increased 166%, substance abuse disorders rose 57%, cardiovascular disorders rose by 71%, metabolic syndrome cases rose 85.9%, systemic arthropathy rose 132% and sleep disorders rose 111%.
   Conclusions Major (potentially ' hidden') clinical comorbidities increased substantially after elective arthroscopic hip surgery when compared with preoperative status. These comorbidities appear to have been overlooked in major studies evaluating the benefits and risks of arthroscopic hip surgery. Level of evidence Prognostic, level III.
C1 [Rhon, Daniel, I; Greenlee, Tina A.] Brooke Army Med Ctr, Ctr Intrepid, Dept Rehabil Med, San Antonio, TX 78234 USA.
   [Rhon, Daniel, I] Baylor Univ, Doctoral Program Phys Therapy, Ft Sam Houston, TX USA.
   [Marchant, Bryant G.] Madigan Army Med Ctr, Dept Orthopaed & Rehabil, Tacoma, WA 98431 USA.
   [Sissel, Charles Dennis] Us Army Med Command, Program Anal & Evaluat Div, Ft Sam Houston, TX USA.
   [Cook, Chad E.] Duke Univ, Dept Orthoped, Div Phys Therapy, Durham, NC USA.
C3 United States Department of Defense; United States Army; San Antonio
   Military Medical Center; Baylor University; Madigan Army Medical Center;
   United States Department of Defense; United States Army; Duke University
RP Rhon, DI (corresponding author), Brooke Army Med Ctr, Dept Rehabil Med, San Antonio, TX 78234 USA.
EM daniel_rhon@baylor.edu
RI Rhon, Daniel/C-9542-2011
OI Rhon, Daniel/0000-0002-4320-990X; Cook, Chad/0000-0001-8622-8361;
   Greenlee, Tina/0000-0002-0638-5998
FU US Defense Health Agency [W911Qy-15-1-0016]
FX This research was supported by an internal grant from the US Defense
   Health Agency (W911Qy-15-1-0016).
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NR 59
TC 20
Z9 20
U1 0
U2 5
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 0306-3674
EI 1473-0480
J9 BRIT J SPORT MED
JI Br. J. Sports Med.
PD MAY
PY 2019
VL 53
IS 9
BP 547
EP +
DI 10.1136/bjsports-2018-099294
PG 8
WC Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Sport Sciences
GA IA3YG
UT WOS:000469498500009
PM 30262452
DA 2025-06-11
ER

PT J
AU Mangurian, C
   Thomas, MD
   Mitsuishi, F
   Goldman, LE
   Niu, G
   Handley, MA
   Riano, NS
   Hwong, A
   Essock, S
   Dilley, J
   Newcomer, JW
   Schillinger, D
AF Mangurian, Christina
   Thomas, Marilyn D.
   Mitsuishi, Fumi
   Goldman, L. Elizabeth
   Niu, Grace
   Handley, Margaret A.
   Riano, Nicholas S.
   Hwong, Alison
   Essock, Susan
   Dilley, James
   Newcomer, John W.
   Schillinger, Dean
TI Lessons Learned From a New Reverse-Integration Model to Improve Primary
   Care Screening in Community Mental Health Settings
SO PSYCHIATRIC SERVICES
LA English
DT Article
AB The authors sought to describe a reverse-integration intervention aimed at improving preventive health screening in a community mental health clinic. The intervention, CRANIUM (cardiometabolic risk assessment and treatment through a novel integration model for underserved populations with mental illness), integrated primary care services into a large urban community mental health setting. It was implemented in 2015 and included a patient- centered team, population-based care, emphasis on screening, and evidence-based treatment. CRANIUM's strengths included provider acceptability, a patient-centered approach, sustained patient engagement, and economic feasibility. Challenges included underutilized staff, registry maintenance, and unanticipated screening barriers. The CRANIUM reverseintegration model can be feasibly implemented and was acceptable to providers.
C1 [Mangurian, Christina; Thomas, Marilyn D.; Mitsuishi, Fumi; Niu, Grace; Riano, Nicholas S.; Hwong, Alison; Dilley, James] Univ Calif San Francisco, Weill Inst Neurosci, Dept Psychiat & Behav Sci, San Francisco, CA 94143 USA.
   [Mangurian, Christina; Handley, Margaret A.] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA.
   [Goldman, L. Elizabeth; Handley, Margaret A.; Schillinger, Dean] San Francisco Gen Hosp, Dept Med, Div Gen Internal Med, San Francisco, CA 94110 USA.
   [Essock, Susan] Columbia Univ, Dept Psychiat, New York, NY USA.
   [Newcomer, John W.] Washington Univ, Sch Med, Dept Psychiat, St Louis, MO USA.
   [Newcomer, John W.] Thriving Mind South Florida, Miami, FL USA.
C3 University of California System; University of California San Francisco;
   University of California System; University of California San Francisco;
   San Francisco General Hospital Medical Center; Columbia University;
   Washington University (WUSTL)
RP Mangurian, C (corresponding author), Univ Calif San Francisco, Weill Inst Neurosci, Dept Psychiat & Behav Sci, San Francisco, CA 94143 USA.; Mangurian, C (corresponding author), Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA.
RI Riano, Nicholas/LIH-0953-2024
OI Hwong, Alison/0000-0002-7443-8019
FU National Institute of Mental Health [K23 MH-093689, R01 MH-112420]; UCSF
   Hellman Fellows Award for Early-Career Faculty; National Center for
   Research Resources; National Center for Advancing Translational
   Sciences; Office of the Director, National Institutes of Health (NIH),
   through the UCSF-Clinical and Translational Science Institute [KL2
   RR-024130]; NIH Center grant from the National Institute of Diabetes and
   Digestive and Kidney Diseases for the Health Delivery Systems-Center for
   Diabetes Translational Research (CDTR) [P30 DK-092924]; Ford Foundation
   fellowship; NIH Ruth L. Kirschstein National Research Service award
   [2T32 MH-018261]; NIH Center grant from the National Institute of
   Diabetes and Digestive and Kidney Diseases for the Health Delivery
   Systems-CDTR [P30 DK-092924]; NIH-National Institute of Minority Health
   and Health Disparities Comprehensive Center of Excellence for Health and
   Risk in Minority Youth and Young Adults [P60 MD-006902]; American
   Psychiatric Association Foundation; National Institute of Mental Health
   Research Education grant [R25 MH-060482]; Substance Abuse and Mental
   Health Services Administration [H79SM080142]; NIH [MH-118395,
   MH-106682]; State of Florida Department of Children and Families
   [KH225]; National Institute of Mental Health [R25MH060482, T32MH018261,
   R34MH118395, R01MH112420] Funding Source: NIH RePORTER
FX Dr. Mangurian was supported by the National Institute of Mental Health
   (grants K23 MH-093689 and R01 MH-112420); the UCSF Hellman Fellows Award
   for Early-Career Faculty; and the National Center for Research
   Resources, the National Center for Advancing Translational Sciences, and
   the Office of the Director, National Institutes of Health (NIH), through
   the UCSF-Clinical and Translational Science Institute (grant KL2
   RR-024130). Dr. Mangurian and Mr. Riano were supported by an NIH Center
   grant (P30 DK-092924) from the National Institute of Diabetes and
   Digestive and Kidney Diseases for the Health Delivery Systems-Center for
   Diabetes Translational Research (CDTR). Dr. Thomas was supported by a
   Ford Foundation fellowship administered by the National Academies of
   Sciences, Engineering, and Medicine. Dr. Niu was supported by an NIH
   Ruth L. Kirschstein National Research Service award (2T32 MH-018261).
   Drs. Handley and Schillinger were supported by an NIH Center grant from
   the National Institute of Diabetes and Digestive and Kidney Diseases for
   the Health Delivery Systems-CDTR (P30 DK-092924) and the NIH-National
   Institute of Minority Health and Health Disparities Comprehensive Center
   of Excellence for Health and Risk in Minority Youth and Young Adults
   (P60 MD-006902). Dr. Hwong was supported by the American Psychiatric
   Association Foundation and by a National Institute of Mental Health
   Research Education grant (R25 MH-060482). In the past 3 years, Dr.
   Newcomer has received grant support from the Substance Abuse and Mental
   Health Services Administration (grant H79SM080142), the NIH (MH-118395
   and MH-106682), and the State of Florida Department of Children and
   Families (KH225). The authors thank the patients and staff at the
   Citywide Focus Clinic, UCSF. The authors also thank several
   administrators within the San Francisco Department of Public Health,
   including David Fariello, L.C.S.W., director of Citywide Focus Clinic;
   Irene Sung, M.D., chief medical officer; Alice Chen, M.D., chief medical
   officer; and Gloria Wilder, Pharm.D., director of pharmacology,
   Behavioral Health Service.
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NR 10
TC 7
Z9 7
U1 0
U2 0
PU AMER PSYCHIATRIC PUBLISHING, INC
PI WASHINGTON
PA 800 MAINE AVE SW, SUITE 900, WASHINGTON, DC 20024 USA
SN 1075-2730
EI 1557-9700
J9 PSYCHIAT SERV
JI Psychiatr. Serv.
PD AUG
PY 2022
VL 73
IS 8
BP 942
EP 945
DI 10.1176/appi.ps.202100177
PG 4
WC Health Policy & Services; Public, Environmental & Occupational Health;
   Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services; Public, Environmental & Occupational
   Health; Psychiatry
GA 6M1BU
UT WOS:000888612700018
PM 35138129
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Andrade, C
AF Andrade, Chittaranjan
TI Physical Exercise and Health, 5: Sedentary Time, Independent of
   Health-Related Physical Activity, as a Risk Factor for Adverse Physical
   Health and Mental Health Outcomes
SO JOURNAL OF CLINICAL PSYCHIATRY
LA English
DT Article
ID BEHAVIOR
AB Medical and neuropsychiatric benefits associated with physical exercise and activity are well recognized. It is less well known that time spent in sedentary behaviors, such as television -viewing or sitting at a desk, are associated with adverse health outcomes even after taking into consideration health -related physical activity. Although sedentary behaviors have become common in daily life, people tend to substantially underestimate how sedentary they actually are. The average person spends nearly 10 hours per day in a sedentary state, during leisure activities or work; sedentariness is even greater in persons with major mental illness such as psychosis. This article explains what sedentariness is, why sedentary behaviors are common in daily life, and how sedentariness is defined and assessed. Sedentariness is an important concept in its own right; it is not merely an absence of health -related physical activity. Sedentariness is associated with adverse outcomes in children and adolescents, adults, and older adults. Examples are provided of associations between sedentariness and adverse medical outcomes such as the metabolic syndrome, cardiovascular disease, stroke, and all cause mortality. Examples are also provided of associations between sedentariness and adverse mental health outcomes such as anxiety, depression, and dementia. Importantly, the adverse associations are independent of health -related physical activity; however, higher levels of physical activity may attenuate or offset the adverse effects of sedentariness. It is hoped that this article will encourage readers to reduce sedentary behaviors with a view to improve long-term physical and mental health.
C1 [Andrade, Chittaranjan] Natl Inst Mental Hlth & Neurosci, Dept Clin Psychopharmacol & Neurotoxicol, Bangalore, India.
C3 National Institute of Mental Health & Neurosciences - India
RP Andrade, C (corresponding author), Natl Inst Mental Hlth & Neurosci, Dept Clin Psychopharmacol & Neurotoxicol, Bangalore, India.
EM candrade@psychiatrist.com
CR Allen MS, 2019, J AFFECT DISORDERS, V242, P5, DOI 10.1016/j.jad.2018.08.081
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NR 20
TC 4
Z9 4
U1 6
U2 17
PU PHYSICIANS POSTGRADUATE PRESS
PI MEMPHIS
PA P O BOX 752870, MEMPHIS, TN 38175-2870 USA
SN 0160-6689
EI 1555-2101
J9 J CLIN PSYCHIAT
JI J. Clin. Psychiatry
PD MAR
PY 2024
VL 85
IS 1
AR 24f15261
DI 10.4088/JCP.24f15261
PG 4
WC Psychology, Clinical; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA RY1J1
UT WOS:001231123400007
PM 38301190
OA Bronze
DA 2025-06-11
ER

PT J
AU Zhong, YH
   Hu, MJ
   Wang, Q
   Yang, ZD
   Zhu, N
   Wang, F
   Zhang, XY
   Zhang, CF
   Min, J
   Wang, H
   Chen, FZ
   Zhao, XD
   Zhang, XY
AF Zhong, Yinghua
   Hu, Manji
   Wang, Qiang
   Yang, Zhendong
   Zhu, Na
   Wang, Fei
   Zhang, Xiyan
   Zhang, Chengfang
   Min, Jie
   Wang, Hao
   Chen, Fazhan
   Zhao, Xudong
   Zhang, Xiangyang
TI The prevalence and related factors of metabolic syndrome in outpatients
   with first-episode drug-naive major depression comorbid with anxiety
SO SCIENTIFIC REPORTS
LA English
DT Article
AB Metabolic syndrome (MetS) is associated with depression, but its role in major depressive disorder comorbid with anxiety (AMD) is unclear. This study aimed to investigate the prevalence and clinical correlates of MetS in first-episode drug-naive (FEDN) patients with AMD in a Chinese Han population. In total, 1380 FEDN outpatients with AMD were recruited in this cross-sectional study. The sociodemographic features, clinical characteristics, history of suicide attempts, thyroid-stimulating hormone (TSH) levels, and MetS parameters of each subject were evaluated. All subjects were rated on the Hamilton Depression Rating Scale (HAM-D), Hamilton Anxiety Rating Scale (HAM-A), and the Positive and Negative Syndrome Scale positive symptom subscale. The prevalence of MetS among AMD patients was 8.04%. Compared to the non-MetS group, age, age of onset, TSH level, HAM-A and HAM-D scores, history of attempted suicide, and comorbid psychiatric symptoms were higher in the MetS group. Those in this group were also more likely to be married, and they had a lower educational level. Furthermore, age, psychiatric symptoms, suicide attempts, and higher TSH levels were independently associated with MetS in AMD patients. This study suggests a lower prevalence of MetS in FEDN patients with AMD in a Chinese Han population. Older age, comorbid psychiatric symptoms, history of attempted suicide, and higher TSH levels are related factors for MetS in AMD patients.
C1 [Zhong, Yinghua; Hu, Manji; Wang, Qiang; Yang, Zhendong; Zhu, Na; Wang, Fei; Zhang, Xiyan; Zhang, Chengfang; Min, Jie; Wang, Hao; Chen, Fazhan; Zhao, Xudong] Tongji Univ, Shanghai Pudong New Area Mental Hlth Ctr, Sch Med, Shanghai, Peoples R China.
   [Zhao, Xudong] Tongji Univ, Sch Med, Div Med Humanities & Behav Sci, 1239 Siping Rd,Postbox 244, Shanghai 200092, Peoples R China.
   [Zhang, Xiangyang] Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China.
   [Zhang, Xiangyang] Univ Chinese Acad Sci, Dept Psychol, 16 Lincui Rd, Beijing 100101, Peoples R China.
C3 Tongji University; Tongji University; Chinese Academy of Sciences;
   Institute of Psychology, CAS; Chinese Academy of Sciences; University of
   Chinese Academy of Sciences, CAS
RP Zhao, XD (corresponding author), Tongji Univ, Shanghai Pudong New Area Mental Hlth Ctr, Sch Med, Shanghai, Peoples R China.; Zhao, XD (corresponding author), Tongji Univ, Sch Med, Div Med Humanities & Behav Sci, 1239 Siping Rd,Postbox 244, Shanghai 200092, Peoples R China.; Zhang, XY (corresponding author), Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China.; Zhang, XY (corresponding author), Univ Chinese Acad Sci, Dept Psychol, 16 Lincui Rd, Beijing 100101, Peoples R China.
EM zhaoxd@tongji.edu.cn; zhangxy@psych.ac.cn
RI Min, Jie/D-2716-2018; Zhang, Xiangyang/ABC-7380-2022; Zhao,
   Xudong/LZF-8356-2025
OI Zhang, Xiangyang/0000-0003-3326-382X; Zhao, Xudong/0000-0003-1493-3517
FU National Natural Science Foundation of China [81771464]; Training Plan
   of Health System Academic Leader of the Shanghai Pudong Municipality
   Health Commission [PWRd2019-08]; Outstanding Clinical Discipline Project
   of Shanghai Pudong [PWYgy2018-10]; Hospital Level Project of Shanghai
   Pudong New Area Mental Health Center [PDJWM201903]; General Project of
   the Shanghai Municipality Health Commission [202040475]
FX This work was supported by the National Natural Science Foundation of
   China (Grant number: 81771464), the Training Plan of Health System
   Academic Leader of the Shanghai Pudong Municipality Health Commission
   (Grant number: PWRd2019-08), the Outstanding Clinical Discipline Project
   of Shanghai Pudong (Grant number: PWYgy2018-10), the Hospital Level
   Project of Shanghai Pudong New Area Mental Health Center (Grant number:
   PDJWM201903), and the General Project of the Shanghai Municipality
   Health Commission (Grant number: 202040475).
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NR 64
TC 12
Z9 13
U1 4
U2 18
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD FEB 8
PY 2021
VL 11
IS 1
AR 3324
DI 10.1038/s41598-021-81653-2
PG 9
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Science & Technology - Other Topics
GA QG5TA
UT WOS:000617646300009
PM 33558554
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Ahles, S
   Joris, PJ
   Plat, J
AF Ahles, Sanne
   Joris, Peter J.
   Plat, Jogchum
TI Effects of Berry Anthocyanins on Cognitive Performance, Vascular
   Function and Cardiometabolic Risk Markers: A Systematic Review of
   Randomized Placebo-Controlled Intervention Studies in Humans
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE anthocyanins; cognitive performance; vascular function; cardiometabolic
   risk markers
ID DOUBLE-BLIND; BLACK-CURRANT; ENDOTHELIAL FUNCTION; BLOOD-PRESSURE;
   ARTERIAL STIFFNESS; METABOLIC SYNDROME; BLUEBERRY SUPPLEMENTATION;
   OXIDATIVE STRESS; CONTROLLED-TRIAL; OLDER-ADULTS
AB Supplementation with anthocyanins, which are a type of flavonoids mainly found in various berries, is hypothesized to be a promising approach to lower the risk of developing cognitive decline. The aim of this systematic review was to provide a comprehensive overview of dietary intervention trials describing effects of berry anthocyanins on cognitive performance in humans, while also addressing potential underlying mechanisms. A total of 1197 articles were identified through a systematic search, and 49 studies reporting effects on cognitive performance (n = 18), vascular function (n = 22), or cardiometabolic risk markers (n = 32) were included. Significant improvements were observed on memory, while some of the studies also reported effects on attention and psychomotor speed or executive function. Vascular function markers such as brachial artery flow-mediated vasodilation were also affected and consistent evidence was provided for the beneficial effects of berry anthocyanins on endothelial function. Finally, studies reported improvements in blood pressure, but effects on metabolic risk markers (e.g. carbohydrate and lipid metabolism) were less consistent. In conclusion, this review provides evidence for the beneficial effects of berry anthocyanins on cognitive performance as memory improved. Whether observed anthocyanin-induced improvements in vascular function and blood pressure underlie beneficial effects on cognitive performance warrants further study.
C1 [Ahles, Sanne; Joris, Peter J.; Plat, Jogchum] Maastricht Univ, Sch Nutr & Translat Res Metab NUTRIM, Dept Nutr & Movement Sci, NL-6200 MD Maastricht, Netherlands.
   [Ahles, Sanne] BioActor BV, Gaetano Martinolaan 85, NL-6229 GS Maastricht, Netherlands.
C3 Maastricht University
RP Plat, J (corresponding author), Maastricht Univ, Sch Nutr & Translat Res Metab NUTRIM, Dept Nutr & Movement Sci, NL-6200 MD Maastricht, Netherlands.
EM s.ahles@maastrichtuniversity.nl; p.joris@maastrichtuniversity.nl;
   j.plat@maastrichtuniversity.nl
RI Joris, Peter/AAT-8570-2021
OI Ahles, Sanne/0000-0001-8194-529X; Joris, Peter J/0000-0001-6852-5776
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NR 88
TC 32
Z9 32
U1 1
U2 24
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD JUN
PY 2021
VL 22
IS 12
AR 6482
DI 10.3390/ijms22126482
PG 25
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA SY8JI
UT WOS:000666126900001
PM 34204250
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Kontari, P
   Smith, KJ
AF Kontari, Panagiota
   Smith, Kimberley J.
TI Risk of dementia associated with cardiometabolic abnormalities and
   depressive symptoms: a longitudinal cohort study using the English
   longitudinal study of ageing
SO INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
LA English
DT Article
DE cardiometabolic risk factors; dementia; depression
ID MILD COGNITIVE IMPAIRMENT; METABOLIC SYNDROME; ALZHEIMERS-DISEASE;
   CARDIOVASCULAR-DISEASE; POTENTIAL ROLE; LATE-LIFE; METAANALYSIS; HEALTH;
   INFLAMMATION; STATEMENT
AB Objectives: Depression and cardiometabolic abnormalities are independently associated with a high risk of dementia. This study aimed to examine the association of comorbid depressive symptoms and cardiometabolic abnormalities with risk of dementia.
   Methods: The sample comprised 4859 participants aged 50 or older without baseline dementia who took part in the English Longitudinal Study of Ageing (waves 2-7). Depressive symptoms were assessed using the Center for Epidemiologic Studies-Depression tool. Cardiometabolic abnormalities were defined as three or more cardiometabolic risk factors (inflammation, central obesity, raised triglycerides, low high-density lipoprotein [HDL] cholesterol, hypertension, and hyperglycaemia or diabetes). Participants were classified into four groups based on presence of depressive symptoms and cardiometabolic abnormalities. Results were analysed using the Cox proportional hazards regression adjusted for covariates.
   Results: A total of 216 cases of incident dementia were reported over 10 years of follow-up. The group with high depressive symptoms only had an increased hazard of developing incident dementia during follow-up (HR = 2.68; 95%CI, 1.70-4.23), which was attenuated after adjustment for baseline cognition. No evidence was found for an association of overall cardiometabolic abnormalities with incident dementia; though hyperglycaemia, hypertension, and abdominal obesity with depressive symptoms had an unadjusted association with incident dementia. Only low-HDL cholesterol with depressive symptoms had an adjusted association with incident dementia (HR = 0.18; 95%CI, 0.04-0.75).
   Conclusions: This work confirms depressive symptoms as a risk factor for incident dementia. However, low HDL-cholesterol with depressive symptoms may be protective against dementia, though more work is required to confirm this association.
C1 [Kontari, Panagiota; Smith, Kimberley J.] Univ Surrey, Sch Psychol, Fac Hlth & Med, Dept Psychol Sci, Guildford, Surrey, England.
C3 University of Surrey
RP Smith, KJ (corresponding author), Univ Surrey, Psychol Sci, Stag Hill Campus, Guildford GU2 7XH, Surrey, England.
EM kimberley.j.smith@surrey.ac.uk
RI Kontari, Panagiota/IAS-0660-2023
OI Kontari, Panagiota/0000-0002-6652-4750; Smith,
   Kimberley/0000-0002-1323-627X
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NR 44
TC 15
Z9 17
U1 2
U2 11
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0885-6230
EI 1099-1166
J9 INT J GERIATR PSYCH
JI Int. J. Geriatr. Psychiatr.
PD FEB
PY 2019
VL 34
IS 2
BP 289
EP 298
DI 10.1002/gps.5019
PG 10
WC Geriatrics & Gerontology; Gerontology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Psychiatry
GA HL6BJ
UT WOS:000458818500011
PM 30370546
OA Green Published, Green Submitted, hybrid
DA 2025-06-11
ER

PT J
AU Das, UN
AF Das, UN
TI A defect in the activity of Δ<SUP>6</SUP> and Δ<SUP>5</SUP> desaturases
   may be a factor predisposing to the development of insulin resistance
   syndrome
SO PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
LA English
DT Article
ID ESSENTIAL FATTY-ACIDS; TUMOR-NECROSIS-FACTOR; DEPENDENT
   DIABETES-MELLITUS; METABOLIC SYNDROME-X; ASIAN INDIAN MEN;
   CAENORHABDITIS-ELEGANS; EICOSAPENTAENOIC ACID; 3T3-L1 ADIPOCYTES;
   SKELETAL-MUSCLE; GAMMA-RADIATION
AB GLUT-4 (glucose transporter) receptor, tumor necrosis factor-alpha (TNF-alpha), interleukins-6 (IL-6), daf-genes and PPARs (peroxisomal proliferation activator receptors) play a role in the development of insulin resistance syndrome and associated conditions. But, the exact interaction between these molecules/factors and the mechanism(s) by which they produce insulin resistance syndrome is not clear.
   I propose that a defect in the activity of the enzymes Delta(6) and Delta(5) desaturases that are essential for the formation of long chain metabolites of essential fatty acids, linoleic acid and alpha-linolenic acid, is a factor in the development of insulin resistance syndrome. Long chain polyunsaturated fatty acids (LCPUFAs) increase cell membrane fluidity and enhance the number of insulin receptors and the affinity of insulin to its receptors; suppress TNF-alpha, IL-6, macrophage migration inhibitory factor (MIF) and leptin synthesis; increase the number of GLUT-4 receptors, serve as endogenous ligands of PPARs, modify lipolysis, and regulate the balance between pro- and anti-oxidants, and thus, play a critical role in the pathogenesis of insulin resistance. In the nematode, Caenorhabditis elegans, the protein encoded by daf-2 is 35% identical to the human insulin receptor; daf-7 codes a transforming growth factor-beta (TGF-beta) type signal and daf-16 enhances superoxide dismutase (SOD) expression. Melatonin has anti-oxidant actions similar to daf-16, TGF-beta and SOD. Calorie restriction enhances the activity of Delta(6) and Delta(5) desaturases, melatonin production, decreases daf-2 signaling, free radical generation, and augments anti-oxidant defenses that may explain the beneficial effect of diet control in the management of obesity, insulin resistance, and type II diabetes mellitus. These evidences suggest that the activities of Delta(6) and Delta(5) enzymes play a critical role in the expression and regulation of GLUT-4, TNF-alpha, IL-6, MIF, daf-genes, melatonin, and leptin by modulating the synthesis and tissue concentrations of LCPUFAs. Caloric restriction delays ageing by activating Sir 2 deacetylase in yeast, and expression of Sir 2 (SIRT1) in human cells. Both insulin and insulin-like growth factor-1 (IGF-1) attenuated this response. SIRT1 sequesters the proapoptotic factor Bax, prevents stress-induced apoptosis of cells, and thus, prolongs survival. In addition, SIRT1 repressed PPAR-gamma, and overexpression of SIRT1 attenuated adipogenesis, and upregulation of SIRT in differentiated fat cells triggered lipolysis and loss of fat, events that are known to attenuate insulin resistance and prolong life span. It remains to be seen whether LCPUFAs have a regulatory role in SIRT1 expression and control Sir 2 deacetylase activity. Thus, calorie restriction or reduced food intake has a role not only in the pathobiology of insulin resistance, but also in other associated conditions such as obesity, type II diabetes mellitus, ageing, and longevity. (c) 2005 Elsevier Ltd. All rights reserved.
C1 UND Life Sci, Walpole, MA 02081 USA.
RP UND Life Sci, 1083 Main St, Walpole, MA 02081 USA.
EM undurti@hotmail.com
RI Das, Undurti/A-7918-2009
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NR 70
TC 119
Z9 130
U1 0
U2 17
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0952-3278
EI 1532-2823
J9 PROSTAG LEUKOTR ESS
JI Prostaglandins Leukot. Essent. Fatty Acids
PD MAY
PY 2005
VL 72
IS 5
BP 343
EP 350
DI 10.1016/j.plefa.2005.01.002
PG 8
WC Biochemistry & Molecular Biology; Cell Biology; Endocrinology &
   Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology; Endocrinology &
   Metabolism
GA 926CU
UT WOS:000229101200004
PM 15850715
DA 2025-06-11
ER

PT J
AU Daches, S
   Vértes, M
   Matthews, K
   Dósa, E
   Kiss, E
   Baji, I
   Kapornai, K
   George, CJ
   Kovacs, M
AF Daches, Shimrit
   Vertes, Miklos
   Matthews, Karen
   Dosa, Edit
   Kiss, Eniko
   Baji, Ildiko
   Kapornai, Krisztina
   George, Charles J.
   Kovacs, Maria
TI Metabolic syndrome among young adults at high and low familial risk for
   depression
SO PSYCHOLOGICAL MEDICINE
LA English
DT Article
DE depression phenotypes; early-onset; high-risk samples; metabolic
   syndrome
ID CARDIOVASCULAR-DISEASE; BIPOLAR DISORDER; MAJOR DEPRESSION; MOOD
   DISORDERS; CHILDHOOD; SYMPTOMS; ASSOCIATION; ANXIETY; METAANALYSIS;
   CHOLESTEROL
AB Background. Our study examined whether the early-onset depression phenotype among young adults (probands) is associated with the metabolic syndrome (MetS) and its components, and if MetS characterizes unaffected but high-risk siblings of probands.
   Methods. We studied three groups of young adults (Mage = 25 years, S.D. = 3.84 years): probands with histories of childhood onset depression - i.e. early-onset phenotype - (n = 293), their unaffected siblings (high-risk siblings, n = 273), and healthy controls (n = 171). Participants completed a full psychiatric interview, physical and laboratory assessments, and self-rating scales. MetS was defined using the criteria of the Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (2001).
   Results. Early-onset depression phenotype and being a high-risk sibling were associated with higher MetS composite scores relative to that of controls, but did not differ from one another. With regard to MetS components: Probands and siblings had similarly larger waist circumference and lower HDL than did controls, while siblings and controls had lower triglyceride levels than did probands but did not differ from one another. Groups did not differ on glucose levels and SBP.
   Conclusions. Our study extends the literature on the association between MetS and depression and underscores the importance of depression phenotypes: failure to account for the clinical heterogeneity of depression may partly underlie the inconsistent findings regarding its relation to MetS. The results also suggest that, in depression-prone populations, MetS may predate and possibly function as a risk factor for eventual depression.
C1 [Daches, Shimrit] Bar Ilan Univ, Dept Psychol, Ramat Gan, Israel.
   [Vertes, Miklos; Dosa, Edit] Semmelweis Univ, Heart & Vasc Ctr, Dept Intervent Radiol, Budapest, Hungary.
   [Matthews, Karen; Kovacs, Maria] Univ Pittsburgh, Sch Med, Dept Psychiat, Pittsburgh, PA USA.
   [Dosa, Edit] Hungarian Vasc Radiol Res Grp, Budapest, Hungary.
   [Kiss, Eniko; Baji, Ildiko; Kapornai, Krisztina] Univ Szeged, Dept Child & Adolescent Psychiat, Szeged, Hungary.
   [George, Charles J.] Univ Pittsburgh, Dept Psychiat, Med Ctr, Pittsburgh, PA USA.
C3 Bar Ilan University; Semmelweis University; Pennsylvania Commonwealth
   System of Higher Education (PCSHE); University of Pittsburgh; Szeged
   University; Pennsylvania Commonwealth System of Higher Education
   (PCSHE); University of Pittsburgh
RP Daches, S (corresponding author), Bar Ilan Univ, Dept Psychol, Ramat Gan, Israel.
EM shimrit.daches@biu.ac.il
RI Vertes, Miklos/AAQ-7457-2020
OI Daches, Shimrit/0000-0002-8328-4699
FU National Institute of Mental Health [R01 HL122648]
FX This study was supported by the National Institute of Mental Health
   Grant (Number: R01 HL122648).
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NR 67
TC 3
Z9 3
U1 2
U2 7
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0033-2917
EI 1469-8978
J9 PSYCHOL MED
JI Psychol. Med.
PD MAR
PY 2023
VL 53
IS 4
BP 1355
EP 1363
DI 10.1017/S0033291721002907
EA AUG 2021
PG 9
WC Psychology, Clinical; Psychiatry; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA D7MY1
UT WOS:000786198400001
PM 34334146
DA 2025-06-11
ER

PT J
AU Javadi, B
   Sobhani, Z
AF Javadi, Behjat
   Sobhani, Zahra
TI Role of apigenin in targeting metabolic syndrome: A systematic review
SO IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
LA English
DT Review
DE Apigenin; Insulin resistance; Metabolic syndrome; Natural products;
   Obesity
ID 3T3-L1 PREADIPOCYTE DIFFERENTIATION; INSULIN-RESISTANCE; OXIDATIVE
   STRESS; CHOLESTEROL EFFLUX; CELL-DAMAGE; PPAR-GAMMA; FLAVONOIDS;
   INFLAMMATION; MICE; PATHOPHYSIOLOGY
AB Metabolic syndrome (MetS) is a cluster of metabolic abnormalities that has a high prevalence worldwide. Apigenin is a flavonoid present in several vegetables and fruits and has anti-inflammatory, anti -oxidant, and anti-MetS properties. This study aims to systematically review the effects of apigenin against MetS and the relevant molecular and cellular mechanisms of action, pharmacokinetics features, and potential structure -activity relationship. Electronic databases including Scopus, PubMed, Science Direct and Cochrane Library were searched for in vivo, and in vitro, and human studies with the following keywords: "apigenin" and "metabolic syndrome or insulin resistance syndrome", "fatty liver", "hypertension or blood pressure", "diabetes or blood glucose", "dyslipidemia", "heart or cardiovascular " and "obesity" in title/abstract. Data were collected from 2000 until 2021 (up to April). Only papers published in the English language were included. Forty-six full -text articles out of 1016 retrieved papers were reviewed and underwent quality assessment by investigators. Antiobesity activity of apigenin is mainly through attenuating adipocyte differentiation by suppressing the mitotic clonal expansion and the adipogenesis-related factors. Its anti -diabetic effects can be exerted through inhibition of protein tyrosine phosphatase1B expression, maintaining the activity of anti -oxidant enzymes, reducing intracellular ROS production, cellular DNA damage, protein carbonylation, and attenuating beta-cell apoptosis. Moreover, apigenin could attenuate dyslipidemia and subsequent atherosclerotic conditions through down -regulating sterol regulatory elementbinding proteins (SREBP)-1c, SREBP-2, stearyl-CoA desaturase-1, and 3-hydroxy-3-methyl-glutarylCoA reductase. Apigenin as a dietary bioactive compound would be a promising candidate for improving MetS and its components.
C1 [Javadi, Behjat; Sobhani, Zahra] Mashhad Univ Med Sci, Sch Pharm, Dept Tradit Pharm, Mashhad, Iran.
C3 Mashhad University of Medical Sciences
RP Sobhani, Z (corresponding author), Mashhad Univ Med Sci, Sch Pharm, Dept Tradit Pharm, Mashhad, Iran.
EM Sobhaniz@mums.ac.ir
RI Javadi, Behjat/AAC-5468-2020; sobhani, zahra/J-9573-2016
FU Research Council of Mashhad University of Medical Sciences, Iran
FX The authors would like to thank the Research Council of Mashhad
   University of Medical Sciences, Iran, for financially supporting this
   study.
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NR 86
TC 4
Z9 4
U1 1
U2 7
PU MASHHAD UNIV MED SCIENCES
PI MASHHAD
PA VICE-CHANCELLOR FOR RES CTR OFF IJBMS, DANESHGAH ST, PO BOX 9138813944 -
   445, MASHHAD, 00000, IRAN
SN 2008-3866
EI 2008-3874
J9 IRAN J BASIC MED SCI
JI Iran. J. Basic Med. Sci.
PD MAY
PY 2024
VL 27
IS 5
BP 524
EP 534
DI 10.22038/IJBMS.2024.71539.15558
PG 11
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA KT5F6
UT WOS:001182221900013
PM 38629096
DA 2025-06-11
ER

PT J
AU Karamzad, N
   Izadi, N
   Sanaie, S
   Ahmadian, E
   Eftekhari, A
   Sullman, MJM
   Safiri, S
AF Karamzad, Nahid
   Izadi, Neda
   Sanaie, Sarvin
   Ahmadian, Elham
   Eftekhari, Aziz
   Sullman, Mark J. M.
   Safiri, Saeid
TI Asthma and metabolic syndrome: a comprehensive systematic review and
   meta-analysis of observational studies
SO JOURNAL OF CARDIOVASCULAR AND THORACIC RESEARCH
LA English
DT Review
DE Metabolic Syndrome; Prevalence; Asthma; Epidemiology; Meta-analysis
ID INSULIN-RESISTANCE; OXIDATIVE STRESS; INCIDENT ASTHMA; LUNG-FUNCTION;
   OBESITY; THERAPY; ABNORMALITIES; EPIDEMIOLOGY; INFLAMMATION; PERSPECTIVE
AB Introduction: This study aimed to perform a meta-analysis on the prevalence of metabolic syndrome (MetS) among patients with asthma and to measure the association asthma has with MetS.
   Methods: The Web of Science, Medline, Scopus, Embase and Google Scholar were searched using the "Asthma", "Metabolic Syndrome", "Dysmetabolic Syndrome", "Cardiovascular Syndrome", "Insulin Resistance Syndrome", "Prevalence", "Odds Ratio", "Cross-Sectional Studies", and "Case-Control Studies" keywords. All observational studies reporting the prevalence of MetS among people with and without asthma were included in the study. In the presence of heterogeneity, random-effects models were used to pool the prevalence and odds ratios (OR), as measures of association in cross-sectional and case-control/ cohort studies, respectively.
   Results: The prevalence of MetS among patients with asthma (8 studies) and the OR comparing the prevalence of MetS among patients with and without asthma (5 studies) were pooled separately. The pooled prevalence of MetS among patients with asthma was found to be 25% (95% confidence interval (CI): 13%-38%). In contrast, the overall pooled OR for MetS in patients with asthma, compared to healthy controls, was 1.34 (95% CI: 0.91-1.76), which was not statistically significant.
   Conclusion: The prevalence of MetS was relatively high in patients with asthma. Furthermore, the odds of MetS was higher in patients with asthma, compared to healthy controls, although this difference was not statistically significant. More original studies among different populations are needed in order to more accurately examine the association between asthma and MetS, as well as the relationship asthma has with the individual components of MetS.
C1 [Karamzad, Nahid] Tabriz Univ Med Sci, Student Res Comm, Tabriz, Iran.
   [Karamzad, Nahid] Tabriz Univ Med Sci, Fac Nutr & Food Sci, Dept Biochem & Diet Therapy, Tabriz, Iran.
   [Karamzad, Nahid] Tabriz Univ Med Sci, Fac Nutr & Food Sci, Nutr Res Ctr, Tabriz, Iran.
   [Izadi, Neda] Shahid Beheshti Univ Med Sci, Sch Publ Hlth & Safety, Dept Epidemiol, Student Res Comm, Tehran, Iran.
   [Sanaie, Sarvin] Tabriz Univ Med Sci, Neurosci Res Ctr, Aging Res Inst, Tabriz, Iran.
   [Ahmadian, Elham; Eftekhari, Aziz] Maragheh Univ Med Sci, Dept Basic Sci, Maragheh, Iran.
   [Sullman, Mark J. M.] Univ Nicosia, Dept Social Sci, Nicosia, Cyprus.
   [Sullman, Mark J. M.] Univ Nicosia, Dept Life & Hlth Sci, Nicosia, Cyprus.
   [Safiri, Saeid] Shahid Beheshti Univ Med Sci, Social Determinants Hlth Res Ctr, Tehran, Iran.
   [Safiri, Saeid] Tabriz Univ Med Sci, TB & Lung Dis Res Ctr, Tabriz, Iran.
   [Safiri, Saeid] Tabriz Univ Med Sci, Rahat Breath & Sleep Res Ctr, Tabriz, Iran.
C3 Tabriz University of Medical Science; Tabriz University of Medical
   Science; Tabriz University of Medical Science; Shahid Beheshti
   University Medical Sciences; Tabriz University of Medical Science;
   University of Nicosia; University of Nicosia; Shahid Beheshti University
   Medical Sciences; Tabriz University of Medical Science; Tabriz
   University of Medical Science
RP Safiri, S (corresponding author), Shahid Beheshti Univ Med Sci, Social Determinants Hlth Res Ctr, Tehran, Iran.; Safiri, S (corresponding author), Tabriz Univ Med Sci, TB & Lung Dis Res Ctr, Tabriz, Iran.; Safiri, S (corresponding author), Tabriz Univ Med Sci, Rahat Breath & Sleep Res Ctr, Tabriz, Iran.
EM saeidsafiri@gmail.com
RI Sanaie, Sarvin/I-3769-2016; Izadi, Neda/AIB-6552-2022; Bitaraf,
   Saeid/M-5618-2019; Ahmadian, Elham/P-8048-2017; Eftekhari,
   Aziz/O-5120-2017
OI Ahmadian, Elham/0000-0002-7230-0489; Eftekhari,
   Aziz/0000-0003-0274-4479; Izadi, Neda/0000-0002-6373-1113
FU Social Determinants of Health Research Center, Shahid Beheshti
   University of Medical Sciences, Tehran, Iran [20974]
FX The present study was supported by Social Determinants of Health
   Research Center, Shahid Beheshti University of Medical Sciences, Tehran,
   Iran (grant No. 20974).
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NR 63
TC 16
Z9 17
U1 1
U2 4
PU TABRIZ UNIV MEDICAL SCIENCES & HEALTH SERVICES
PI TABRIZ
PA DANESHGHAH ST, TABRIZ, REPUBLIC ISLAMIC 51664-14766, IRAN
SN 2008-5117
EI 2008-6830
J9 J CARDIOVASC THORAC
JI J. Cardiovasc. Thorac. Res.
PY 2020
VL 12
IS 2
BP 120
EP 128
DI 10.34172/jcvtr.2020.20
PG 9
WC Cardiac & Cardiovascular Systems
WE Emerging Sources Citation Index (ESCI)
SC Cardiovascular System & Cardiology
GA LY1XL
UT WOS:000540314600007
PM 32626552
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Lipovac, M
   Chedraui, P
   Gruenhut, C
   Gocan, A
   Stammler, M
   Imhof, M
AF Lipovac, Markus
   Chedraui, Peter
   Gruenhut, Christine
   Gocan, Ana
   Stammler, Maria
   Imhof, Martin
TI Improvement of postmenopausal depressive and anxiety symptoms after
   treatment with isoflavones derived from red clover extracts
SO MATURITAS
LA English
DT Article
DE Depressive mood; Anxiety; Postmenopause; Red clover; Isoflavones
ID DIETARY SOY PHYTOESTROGENS; HUMAN ENDOTHELIAL-CELLS; MENOPAUSE
   RATING-SCALE; MIDLIFE WOMENS HEALTH; MIDDLE-AGED WOMEN; QUALITY-OF-LIFE;
   TRIFOLIUM-PRATENSE; ESTROGENIC ACTIVITY; METABOLIC SYNDROME;
   HORMONE-THERAPY
AB Objective: To evaluate the effect of isoflavones derived from red clover extracts (MF11RCE) over anxiety and depressive symptoms among postmenopausal women.
   Methods: One hundred and nine postmenopausal women aged 40 or more were randomly assigned to receive two daily capsules of MF11RCE (80 mg red clover isoflavones, Group A) or placebo of equal appearance (Group B) for a 90-day period. After a washout period of 7 days, medication was crossed over and taken for 90 days more. Anxiety and depressive symptoms were measured at baseline, 90 and 187 days with the Hospital Anxiety and Depression Scale (HADS) and Zung's Self Rating Depression Scale (SDS).
   Results: After receiving the MF11RCE compound the total HADS (anxiety and depression subscale scores also) and the total SDS scores decreased significantly. This effect was equivalent to a 76.9% reduction in the total HADS score (76% for anxiety and 78.3% for depression) and an 80.6% reduction in the total SDS score. After placebo, total HADS (anxiety and depression subscale also) and total SDS scores also decreased significantly in comparison to baseline but only equivalent to an average 21.7% decline.
   Conclusion: Red clover derived isoflavones (MF11RCE) were effective in reducing depressive and anxiety symptoms among postmenopausal women. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
C1 [Chedraui, Peter] Inst Salud Mujer, Guayaquil, Ecuador.
   [Lipovac, Markus; Imhof, Martin] Gen Teaching Hosp Korneuburg, Div Obstet & Gynecol, Korneuburg, Austria.
   [Gruenhut, Christine; Gocan, Ana] Study Ctr Med XIX, A-1190 Vienna, Austria.
   [Stammler, Maria] Med Univ Vienna, Div Obstet & Gynecol, Vienna, Austria.
C3 Medical University of Vienna
RP Chedraui, P (corresponding author), Inst Salud Mujer, Velez 616 & Garcia Aviles,POB 09-02000-70-A, Guayaquil, Ecuador.
EM institutochedraui@gmail.com
RI Blümel, Juan Enrique/JUV-6950-2023
FU Melbrosin International, Produktions and Vertriebs GmbH & Co KG, Vienna,
   Austria
FX This study was supported by Melbrosin International, Produktions and
   Vertriebs GmbH & Co KG, Vienna, Austria and presented as a free
   communication at the 12th World Congress on the Menopause, Madrid-Spain,
   May 19-23, 2008.
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NR 52
TC 49
Z9 53
U1 2
U2 22
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0378-5122
EI 1873-4111
J9 MATURITAS
JI Maturitas
PD MAR
PY 2010
VL 65
IS 3
BP 258
EP 261
DI 10.1016/j.maturitas.2009.10.014
PG 4
WC Geriatrics & Gerontology; Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology; Obstetrics & Gynecology
GA 574MG
UT WOS:000275992900014
PM 19948385
DA 2025-06-11
ER

PT J
AU Schlotz, W
   Ambery, P
   Syddall, HE
   Crozier, SR
   Sayer, AA
   Cooper, C
   Phillips, DIW
AF Schlotz, Wolff
   Ambery, Phil
   Syddall, Holly E.
   Crozier, Sarah R.
   Sayer, Avan Aihie
   Cooper, Cyrus
   Phillips, David I. W.
CA Hertfordshire Cohort Study Grp
TI Specific associations of insulin resistance with impaired health-related
   quality of life in the Hertfordshire Cohort Study
SO QUALITY OF LIFE RESEARCH
LA English
DT Article
DE insulin resistance; HOMA-IR; health-related quality of life; physical
   functioning; SF-36; subjective health
ID BETA-CELL FUNCTION; SURVEY QUESTIONNAIRE; COMORBID DEPRESSION; ANXIETY
   DISORDERS; GLUCOSE-UPTAKE; WHITEHALL-II; SF-36; PREVALENCE; WEIGHT; HOMA
AB Insulin resistance is a metabolic abnormality that underlies Type 2 diabetes, the metabolic syndrome and cardiovascular disease, but it may also be associated with more global health deficits. This study assessed associations of insulin resistance with health-related quality of life (HRQoL) in different domains of physical and mental health in a large elderly population study. Cross-sectional data of 1212 participants from the Hertfordshire Cohort Study were analysed. Insulin resistance was assessed by the homeostatic model assessment (HOMA-IR), and HRQoL was measured using the SF-36 health survey. Poor HRQoL was defined by a score lower than the sex-specific 10th percentile of each scale, and logistic regressions yielded odds ratios in relation to the HOMA-IR scores. Subsequent analyses adjusted for the influence of age, smoking, alcohol consumption, social class, BMI, coronary heart disease and depression. Results showed an increase in poor HRQoL with an increase in HOMA-IR scores for physical functioning (OR = 2.29; CI: 1.67-3.13), vitality (OR = 1.45; CI: 1.05-2.00), and general health (OR = 1.62; CI: 1.19-2.21). In men, but not in women, associations with physical functioning were independent of confounding variables. The results indicate that insulin resistance is associated with poor HRQoL in domains of physical health, but not in domains of mental health.
C1 Univ Southampton, MRC, Epidemiol Resource Ctr, Southampton Gen Hosp, Southampton SO16 6YD, Hants, England.
C3 University of Southampton
RP Schlotz, W (corresponding author), Univ Southampton, MRC, Epidemiol Resource Ctr, Southampton Gen Hosp, Southampton SO16 6YD, Hants, England.
EM ws@mrc.soton.ac.uk
RI Cooper, Cyrus/ADV-7232-2022; Schlotz, Wolff/AAI-9549-2020; Sayer,
   Avan/A-4359-2012
OI Cooper, Cyrus/0000-0003-3510-0709; Crozier, Sarah/0000-0002-9524-1127;
   Syddall, Holly/0000-0003-0171-0306; Schlotz, Wolff/0000-0003-2356-7766;
   Aihie Sayer, Avan/0000-0003-1283-6457
FU Medical Research Council [MC_U147574213, MC_U147585824, MC_UP_A620_1014,
   U.1475.00.002.00001.01(74213)] Funding Source: Medline
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NR 30
TC 34
Z9 35
U1 0
U2 4
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0962-9343
EI 1573-2649
J9 QUAL LIFE RES
JI Qual. Life Res.
PD APR
PY 2007
VL 16
IS 3
BP 429
EP 436
DI 10.1007/s11136-006-9129-5
PG 8
WC Health Care Sciences & Services; Health Policy & Services; Public,
   Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services; Public, Environmental & Occupational
   Health
GA 143AQ
UT WOS:000244692800006
PM 17091361
DA 2025-06-11
ER

PT J
AU Porter, C
   Aggar, C
AF Porter, Cassandra
   Aggar, Christina
TI A practical toolkit to support Australian mental health clinicians to
   manage Metabolic Syndrome: A pilot study
SO INTERNATIONAL JOURNAL OF MENTAL HEALTH NURSING
LA English
DT Article
DE mental health; metabolic syndrome; physical health; screening; severe
   mental illness; staff development
ID PHYSICAL HEALTH; NURSES ATTITUDES; PEOPLE; CARE; ILLNESS; DISORDERS;
   NEEDS
AB Metabolic syndrome (MetS) results in poor physical health outcomes and reduced life expectancy of up to 20 years less for people living with severe mental illness. The aim of this pilot study was to evaluate a locally developed practical toolkit (Let's Get Physical-Improved Physical Health in Mental Health Services-A Practical Toolkit) to support mental health clinicians to manage MetS. The study explored clinician's knowledge and attitudes towards managing MetS, confidence to screen for and intervene in MetS, and improvement in documentation. A longitudinal prospective study, utilizing audit and pre-post-questionnaire design, was conducted. Of the 60 clinicians who were employed in the regional inpatient unit, 65% (n = 39) participated in at least one of the intervention education sessions. The final sample comprised 17 clinicians with matched pre- and post-intervention data (28% of eligible participants). A total of 80 (20 per month) eMR metabolic monitoring form and patient file audits were conducted. Whilst the results were not statistically significant, this study found an overall improvement in clinicians' knowledge of, and confidence to screen for and intervene in, MetS. Attitude scores were overall positive. There was also overall improvement in MetS documentation. The implementation of the practical evidence-informed physical health in mental health services toolkit may have a positive impact on clinician knowledge, attitudes, and confidence in screening and intervening in MetS. Replicating this study with a larger sample is recommended.
C1 [Porter, Cassandra] Northern NSW Local Hlth Dist, Mental Hlth Serv, 16 Powell St, Tweed Heads, NSW 2485, Australia.
   [Aggar, Christina] Southern Cross Univ, Sch Hlth & Human Sci, Lismore, NSW, Australia.
   [Aggar, Christina] Northern NSW Local Hlth Dist, Nursing & Midwifery Directorate, Lismore, NSW, Australia.
C3 Southern Cross University
RP Porter, C (corresponding author), Northern NSW Local Hlth Dist, Mental Hlth Serv, 16 Powell St, Tweed Heads, NSW 2485, Australia.
EM Cassandra.porter@health.nsw.-gov.au
RI Aggar, Christina/ABD-7762-2021
OI Aggar, Christina/0000-0002-0137-7796; Tognarini,
   Cassandra/0000-0002-7224-8393
FU Northern NSW Local Health District Mental Health Services
FX This research was funded by Northern NSW Local Health District Mental
   Health Services. The funders were not involved in the study design, data
   collection, data analysis and interpretation, or writing of the
   manuscript. The funders were involved in the decision to submit this
   article for publication.
CR [Anonymous], 2014, Australias physical activity and sedentary behaviour guidelines
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NR 26
TC 1
Z9 1
U1 0
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1445-8330
EI 1447-0349
J9 INT J MENT HEALTH NU
JI Int. J. Ment. Health Nurs.
PD OCT
PY 2021
VL 30
SU 1
BP 1417
EP 1425
DI 10.1111/inm.12899
EA JUN 2021
PG 9
WC Nursing; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Psychiatry
GA UN1NP
UT WOS:000660418800001
PM 34117825
DA 2025-06-11
ER

PT J
AU Wu, B
   Huang, JS
   Fukuo, K
   Suzuki, K
   Yoshino, G
   Kazumi, T
AF Wu, Bin
   Huang, Jingshan
   Fukuo, Keisuke
   Suzuki, Kazuhisa
   Yoshino, Gen
   Kazumi, Tsutomu
TI Different Associations of Trunk and Lower-Body Fat Mass Distribution
   with Cardiometabolic Risk Factors between Healthy Middle-Aged Men and
   Women
SO INTERNATIONAL JOURNAL OF ENDOCRINOLOGY
LA English
DT Article
ID DENSITY-LIPOPROTEIN CHOLESTEROL; INTIMA-MEDIA THICKNESS; X-RAY
   ABSORPTIOMETRY; INSULIN SENSITIVITY; ABDOMINAL FAT; METABOLIC SYNDROME;
   CARDIOVASCULAR-DISEASE; WAIST CIRCUMFERENCE; PLASMA; INDEX
AB The aim of this study was to assess whether the gender-specific pattern of fat mass (FM) distribution is related to gender differences in cardiometabolic risk factors. 207 healthy middle-aged Japanese were included in the study. We measured FM in the total body, trunk, and lower-body with dual-energy X-ray absorptiometry (DXA). The percentage of trunk FM (TFM) and lower-body FM (LFM) is noted as % TFM and % LFM, respectively. Other measurements included glucose and insulin during oral glucose tolerance test (OGTT), leptin, adiponectin, plasminogen activator inhibitor-1 (PAI-1), tumor necrosis factor-alpha (TNF-alpha), C-reactive protein (CRP), and systemic oxidative stress marker. Arterial properties were indicated by cardio-ankle vascular index (CAVI) and intima-media thickness (IMT) of the common carotid artery. The results showed that % TFM is higher whereas % LFM is lower in men than in women and men have a more atherogenic cardiometabolic profile. In both genders, % TFM (% LFM) is related to an unfavorable (favorable) cardiometabolic profile. In particular, the relation between % LFM and OGTT-derived insulin sensitivity index is stronger in women than in men. These findings suggested that in relatively healthy adults, android and gynoid pattern of FM distribution contributes to gender differences in cardiometabolic risk factors.
C1 [Wu, Bin; Fukuo, Keisuke; Suzuki, Kazuhisa; Kazumi, Tsutomu] Mukogawa Womens Univ, Open Res Ctr Studying Lifestyle Related Dis, 6-46 Ikebiraki Cho, Nishinomiya, Hyogo 6638558, Japan.
   [Wu, Bin] Kunming Med Univ, Affiliated Hosp 1, Dept Endocrinol, Kunming 650032, Yunnan, Peoples R China.
   [Huang, Jingshan] Univ S Alabama, Sch Comp, Mobile, AL 36688 USA.
   [Fukuo, Keisuke] Mukogawa Womens Univ, Sch Human Environm Sci, Dept Food Sci & Nutr, 6-46 Ikebiraki Cho, Nishinomiya, Hyogo 6638558, Japan.
   [Fukuo, Keisuke; Kazumi, Tsutomu] Mukogawa Womens Univ, Res Inst Nutr Sci, 6-46 Ikebiraki Cho, Nishinomiya, Hyogo 6638558, Japan.
   [Yoshino, Gen] Toho Univ, Omori Med Ctr, Dept Diabet & Endocrinol, Omori Ku, Omorinishi 6-11-1, Tokyo 1438541, Japan.
C3 Mukogawa Women's University; Kunming Medical University; University of
   South Alabama; Mukogawa Women's University; Mukogawa Women's University;
   Toho University
RP Wu, B (corresponding author), Mukogawa Womens Univ, Open Res Ctr Studying Lifestyle Related Dis, 6-46 Ikebiraki Cho, Nishinomiya, Hyogo 6638558, Japan.; Wu, B (corresponding author), Kunming Med Univ, Affiliated Hosp 1, Dept Endocrinol, Kunming 650032, Yunnan, Peoples R China.
EM wu.bin.kmu@qq.com
RI Wu, Bin/R-7389-2019
OI Kazumi, Tsutomu/0000-0002-8855-9268; Wu, Bin/0000-0002-0399-0762; Huang,
   Jingshan/0000-0003-2408-2883
FU Ministry of Education, Culture, Sports, Science, and Technology (MEXT)
   of Japan; National Natural Science Foundation of China (NSFC)
   [81660141]; Science and Technology Department of the Applied Basic
   Research Foundation of Yunnan Province [2015FB023]; National Cancer
   Institute (NCI) of the National Institutes of Health (NIH) [U01CA180982]
FX The authors are indebted to all the participants for their dedicated and
   conscientious collaboration. They also thank Mami Toyasaki and Rumi
   Fukada for their work on sampling and data collection. This study was
   supported by the Open Research Center Project for Private University:
   Matching Fund Subsidy for Private Universities from the Ministry of
   Education, Culture, Sports, Science, and Technology (MEXT) of Japan. In
   addition, the research reported in this paper was partially supported by
   (1) the National Natural Science Foundation of China (NSFC) (Award no.
   81660141), (2) the Science and Technology Department of the Applied
   Basic Research Foundation of Yunnan Province (no. 2015FB023), and (3)
   the National Cancer Institute (NCI) of the National Institutes of Health
   (NIH) (Award no. U01CA180982).
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NR 40
TC 18
Z9 20
U1 0
U2 4
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1687-8337
EI 1687-8345
J9 INT J ENDOCRINOL
JI Int. J. Endocrinol.
PY 2018
VL 2018
AR 1289485
DI 10.1155/2018/1289485
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA FW6FQ
UT WOS:000425414000001
PM 29531527
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Skorodensky, M
   Skodová, Z
   Takác, P
   Mechírová, V
   Pálová, E
   Tajtáková, M
   Gibalová, M
AF Skorodensky, Miroslav
   Skodova, Zuzana
   Takac, Peter
   Mechirova, Viola
   Palova, Eva
   Tajtakova, Maria
   Gibalova, Martina
TI Psychological, medical and bio-behavioral factors in coronary heart
   disease
SO STUDIA PSYCHOLOGICA
LA English
DT Article
DE hostility; depression; coronary heart disease; metabolic syndrome;
   growth hormone insufficiency
ID ORGANIC-DISEASE; DEPRESSION; MORTALITY
AB The aim of this study is to emphasize the importance of an integrative bio-behavioral approach to coronary heart disease. We explored relationships between psychological characteristics and traditional biomedical risk factors of coronary heart disease, by using specific methods not commonly used in Slovakia (VCE interview, RIA serotonin levels assessment). A structured interview was conducted with 89 patients, who were divided into 4 diagnostic groups: 1) cardiac patients after myocardial infarction (MI), 2) patients suffering from metabolic syndrome, 3) patients with depression, and 4) participants with growth hormone insufficiency. The VCE interview (Friedman, Ghandour, 1993) was used to assess the levels of free-floating hostility and time urgency. Beck's questionnaires (BDI, BAI) and Zung's inventory were employed in order to explore depression and anxiety. The B.P.A.I. questionnaire was used as the measure of anger and hostility. Medical and biochemical examinations were also performed (e.g., BMI, blood pressure, Doppler, EKG, cholesterol, serotonin). ANOVA, Pearson's coefficients and factor analysis were used as the statistical methods. Cardiac patients after MI scored significantly higher in free-floating hostility, time urgency and total score of the VCE interview compared to all other groups. It has been shown that results of the VCE structured interview are efficient in distinguishing patients with coronary heart disease from patients without this disorder. Cardiac patients also had higher levels of anxiety and depression, which were significantly associated with the lowest serotonin levels in this group. The group of patients with metabolic syndrome had higher levels of the above-mentioned variables compared to the group with depression and growth hormone insufficiency, which illustrates on the psychological level that metabolic syndrome might be perceived as an antecedent of future coronary heart disease. The trend of higher cardiac risk in patients suffering from depression was also partially confirmed. The results of the present study showed that psychosocial factors, especially free-floating hostility and time urgency, are strongly connected to the somatic risk factors which play an important role in the origin and development of coronary heart disease. More attention should be paid to psychosocial factors when considering the treatment and prevention of coronary heart disease.
C1 [Skorodensky, Miroslav; Gibalova, Martina] Univ Presov, Philosophy Fac, Inst Psychol, Dept Clin Psychol & Hlth Psychol, Presov, Slovakia.
   [Skodova, Zuzana] Safarik Univ, Fac Arts, Dept Educ & Hlth Psychol, Kosice, Slovakia.
   [Takac, Peter; Palova, Eva; Tajtakova, Maria] Fac Hosp L Pasteur, Kosice, Slovakia.
   [Takac, Peter] Med Fac UPJS, Dept Phys Med & Rehabil, Kosice, Slovakia.
   [Mechirova, Viola] Med Fac UPJS, Inst Bachelor & Master Study, Kosice, Slovakia.
   [Palova, Eva] Med Fac UPJS, Psychiat Clin, Kosice, Slovakia.
   [Tajtakova, Maria] Med Fac UPJS, Internal Clin 1, Kosice, Slovakia.
C3 University of Presov; University of Pavol Jozef Safarik Kosice;
   University of Pavol Jozef Safarik Kosice; University of Pavol Jozef
   Safarik Kosice; University of Pavol Jozef Safarik Kosice; University of
   Pavol Jozef Safarik Kosice
RP Skorodensky, M (corresponding author), Univ Presov, Philosophy Fac, Inst Psychol, Dept Clin Psychol & Hlth Psychol, 17 Novembra 1, Presov, Slovakia.
EM skorodensky@atknet.sk
RI Palova, Eva/AAD-5304-2019; Skodova, Zuzana/F-8133-2013
OI Skodova, Zuzana/0000-0002-1885-6443; Takac, Peter/0000-0002-6615-1894
CR [Anonymous], PSYCHOSOMATICKA MED
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NR 22
TC 0
Z9 0
U1 0
U2 4
PU SLOVAK ACAD SCIENCES, CTR SOCIAL & PSYCHOLOGICAL SCIENCES, IEP
PI BRATISLAVA
PA DUBRAVSKA CESTA 9, 813 64 BRATISLAVA, SLOVAKIA
SN 0039-3320
EI 2585-8815
J9 STUD PSYCHOL
JI Studia Psychol.
PY 2007
VL 49
IS 4
BP 321
EP 331
PG 11
WC Psychology, Multidisciplinary
WE Social Science Citation Index (SSCI)
SC Psychology
GA 257SQ
UT WOS:000252819200004
DA 2025-06-11
ER

PT J
AU Yates, KF
   Sweat, V
   Yau, PL
   Turchiano, MM
   Convit, A
AF Yates, Kathy F.
   Sweat, Victoria
   Yau, Po Lai
   Turchiano, Michael M.
   Convit, Antonio
TI Impact of Metabolic Syndrome on Cognition and Brain A Selected Review of
   the Literature
SO ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
LA English
DT Review
DE metabolic syndrome; cognitive performance; adults; adolescents; brain
   imaging
ID INTIMA-MEDIA THICKNESS; INSULIN-RESISTANCE SYNDROME; TYPE-2
   DIABETES-MELLITUS; SCHOOL-AGE-CHILDREN; OBESE ADOLESCENTS;
   BLOOD-PRESSURE; CARDIOVASCULAR-DISEASE; EXECUTIVE DYSFUNCTION; ARTERIAL
   STIFFNESS; UNITED-STATES
AB Metabolic syndrome (MetS), a clustering of risk factors for type 2 diabetes mellitus and cardiovascular disease, has been associated with cognitive dysfunction and brain abnormalities. This review describes the literature on the impact of MetS on brain and cognition and suggests directions for future research. A literature search for reports of MetS and cognition and brain imaging was conducted for both nonelderly adults and adolescents. No studies were found describing MetS and brain or cognition among adolescents; therefore, we also included studies investigating individual components of MetS in this age group. Most studies found associations between MetS and cognitive dysfunction. Multiple cognitive domains were affected by MetS in adults. In adolescents, the majority of findings were in executive functioning. Brain imaging literature in adults implicated MetS in ischemic stroke, white matter alterations, and altered brain metabolism. For adolescents, individual MetS factors were linked to volume losses in the hippocampus and frontal lobes. MetS negatively impacts cognitive performance and brain structure. Potential explanatory models include impaired vascular reactivity, neuroinflammation, oxidative stress, and abnormal brain lipid metabolism. We posit that insulin resistance-associated impairment in cerebrovascular reactivity is an important mechanism underlying brain deficits seen in MetS. (Arterioscler Thromb Vasc Biol. 2012;32:2060-2067.)
C1 [Convit, Antonio] NYU, Sch Med, Brain Obes & Diabet Lab BODyLab, Dept Psychiat, New York, NY 10016 USA.
   [Convit, Antonio] NYU, Sch Med, Dept Med, New York, NY 10016 USA.
   [Yates, Kathy F.; Convit, Antonio] Nathan S Kline Inst Psychiat Res, Orangeburg, NY USA.
C3 New York University; New York University; Nathan Kline Institute for
   Psychiatric Research
RP Convit, A (corresponding author), NYU, Sch Med, Brain Obes & Diabet Lab BODyLab, Dept Psychiat, 145 E 32nd St,8th Floor, New York, NY 10016 USA.
EM Antonio.Convit@NYUMC.org
OI Yates, Kathy/0000-0002-1844-8431; Convit, Antonio/0000-0003-2201-2689;
   Yau, Po Lai/0000-0002-2901-2705
FU National Institutes of Health [DK064087, DK083537]
FX The study was supported by National Institutes of Health grants DK064087
   and DK083537.
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NR 84
TC 333
Z9 363
U1 1
U2 62
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1079-5642
EI 1524-4636
J9 ARTERIOSCL THROM VAS
JI Arterioscler. Thromb. Vasc. Biol.
PD SEP
PY 2012
VL 32
IS 9
BP 2060
EP 2067
DI 10.1161/ATVBAHA.112.252759
PG 8
WC Hematology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Hematology; Cardiovascular System & Cardiology
GA 992JZ
UT WOS:000307773100007
PM 22895667
OA Bronze, Green Accepted
DA 2025-06-11
ER

PT J
AU Mangurian, C
   Niu, GC
   Schillinger, D
   Newcomer, JW
   Dilley, J
   Handley, MA
AF Mangurian, Christina
   Niu, Grace C.
   Schillinger, Dean
   Newcomer, John W.
   Dilley, James
   Handley, Margaret A.
TI Utilization of the Behavior Change Wheel framework to develop a model to
   improve cardiometabolic screening for people with severe mental illness
SO IMPLEMENTATION SCIENCE
LA English
DT Article
DE Cardiometabolic screening; Severe mental illness; Behavior change wheel
ID CLINICAL DECISION-SUPPORT; MEDICAL-CARE MANAGEMENT; COLLABORATIVE CARE;
   HEALTH-CARE; DEPRESSIVE SYMPTOMS; METABOLIC SYNDROME; IMPLEMENTATION;
   SCHIZOPHRENIA; INTERVENTIONS; IMPACT
AB Background: Individuals with severe mental illness (e.g., schizophrenia, bipolar disorder) die 10-25 years earlier than the general population, primarily from premature cardiovascular disease (CVD). Contributing factors are complex, but include systemic-related factors of poorly integrated primary care and mental health services. Although evidence-based models exist for integrating mental health care into primary care settings, the evidence base for integrating medical care into specialty mental health settings is limited. Such models are referred to as "reverse" integration. In this paper, we describe the application of an implementation science framework in designing a model to improve CVD outcomes for individuals with severe mental illness (SMI) who receive services in a community mental health setting.
   Methods: Using principles from the theory of planned behavior, focus groups were conducted to understand stakeholder perspectives of barriers to CVD risk factor screening and treatment identify potential target behaviors. We then applied results to the overarching Behavior Change Wheel framework, a systematic and theory-driven approach that incorporates the COM-B model (capability, opportunity, motivation, and behavior), to build an intervention to improve CVD risk factor screening and treatment for people with SMI.
   Results: Following a stepped approach from the Behavior Change Wheel framework, a model to deliver primary preventive care for people that use community mental health settings as their de facto health home was developed. The CRANIUM (cardiometabolic risk assessment and treatment through a novel integration model for underserved populations with mental illness) model focuses on engaging community psychiatrists to expand their scope of practice to become responsible for CVD risk, with significant clinical decision support.
   Conclusion: The CRANIUM model was designed by integrating behavioral change theory and implementation theory. CRANIUM is feasible to implement, is highly acceptable to, and targets provider behavior change, and is replicable and efficient for helping to integrate primary preventive care services in community mental health settings. CRANIUM can be scaled up to increase CVD preventive care delivery and ultimately improve health outcomes among people with SMI served within a public mental health care system.
C1 [Mangurian, Christina; Niu, Grace C.; Dilley, James] UCSF Zuckerberg San Francisco Gen ZSFG, Weill Inst Neurosci, Dept Psychiat, 1001 Potrero Ave, San Francisco, CA 94110 USA.
   [Mangurian, Christina; Schillinger, Dean; Handley, Margaret A.] UCSF Ctr Vulnerable Populat ZSFG, San Francisco, CA 94110 USA.
   [Schillinger, Dean; Handley, Margaret A.] UCSF Dept Med, Div Gen Internal Med ZSFG, 1001 Potrero Ave,1320A, San Francisco, CA 94110 USA.
   [Newcomer, John W.] Florida Atlantic Univ, Charles E Schmidt Coll Med, Dept Clin Biomed Sci, 777 Glades Rd,BC-71 Rm 241, Boca Raton, FL 33431 USA.
   [Handley, Margaret A.] UCSF Dept Epidemiol & Biostat, 550 16th St, San Francisco, CA 64158 USA.
C3 State University System of Florida; Florida Atlantic University
RP Mangurian, C (corresponding author), UCSF Zuckerberg San Francisco Gen ZSFG, Weill Inst Neurosci, Dept Psychiat, 1001 Potrero Ave, San Francisco, CA 94110 USA.; Mangurian, C (corresponding author), UCSF Ctr Vulnerable Populat ZSFG, San Francisco, CA 94110 USA.
EM Christina.Mangurian@ucsf.edu
OI Newcomer, John/0000-0003-2153-9382
FU National Institutes of Mental Health [1K23MH093689]; UCSF Hellman
   Fellows Award for Early-Career Faculty; National Center for Research
   Resources; National Center for Advancing Translational Sciences; Office
   of the Director, National Institutes of Health, through UCSF-CTSI
   [KL2RR024130]; NIH [2T32MH018261]; University of Washington AIMS Center;
   NIH from the National Institute of Diabetes and Digestive and Kidney
   Diseases for The Health Delivery Systems-Center for Diabetes
   Translational Research (CDTR) [P30DK092924]; NIH/National Institute of
   Minority Health and Health Disparities (NIMHD) Comprehensive Center of
   Excellence for Health and Risk in Minority Youth and Young Adults
   [P60MD006902]; National Center for Advancing Translational Sciences,
   National Institutes of Health, through UCSF-CTSI [UL1TR001872]; National
   Center for Advancing Translational Sciences [UL1TR001872] Funding
   Source: NIH RePORTER; National Institute of Mental Health [T32MH018261]
   Funding Source: NIH RePORTER
FX CM was supported by the National Institutes of Mental Health
   (1K23MH093689), the UCSF Hellman Fellows Award for Early-Career Faculty,
   and the National Center for Research Resources, the National Center for
   Advancing Translational Sciences, and the Office of the Director,
   National Institutes of Health, through UCSF-CTSI Grant Number
   KL2RR024130. GN was supported by the NIH Ruth L. Kirschstein National
   Research Service Award (2T32MH018261) and consulting fees from
   University of Washington AIMS Center. DS and MH were supported by the
   NIH Center Grant from the National Institute of Diabetes and Digestive
   and Kidney Diseases for The Health Delivery Systems-Center for Diabetes
   Translational Research (CDTR) (P30DK092924) and the NIH/National
   Institute of Minority Health and Health Disparities (NIMHD)
   Comprehensive Center of Excellence for Health and Risk in Minority Youth
   and Young Adults (P60MD006902). MH was also supported by the National
   Center for Advancing Translational Sciences, National Institutes of
   Health, through UCSF-CTSI Grant Number UL1TR001872. The contents are
   solely the responsibility of the authors and do not necessarily
   represent the official views of the NIH. The NIH did not play a role in
   the design of the study or collection, analysis, or interpretation of
   data, or in writing the manuscript.
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NR 94
TC 48
Z9 52
U1 3
U2 40
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1748-5908
J9 IMPLEMENT SCI
JI Implement. Sci.
PD NOV 14
PY 2017
VL 12
AR 134
DI 10.1186/s13012-017-0663-z
PG 16
WC Health Care Sciences & Services; Health Policy & Services
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services
GA FM7KZ
UT WOS:000415256900005
PM 29137666
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Fiedorowicz, JG
   He, JP
   Merikangas, KR
AF Fiedorowicz, Jess G.
   He, Jianping
   Merikangas, Kathleen R.
TI The association between mood and anxiety disorders with vascular
   diseases and risk factors in a nationally representative sample
SO JOURNAL OF PSYCHOSOMATIC RESEARCH
LA English
DT Article
DE Anxiety disorders; Diabetes mellitus; Hypertension; Obesity; Mood
   disorders; Vascular diseases
ID MAJOR DEPRESSIVE DISORDER; CORONARY-HEART-DISEASE; GENERAL MEDICAL
   CONDITIONS; REPLICATION NCS-R; MENTAL-HEALTH; METABOLIC SYNDROME;
   CARDIOVASCULAR-DISEASE; BIPOLAR-DISORDER; EXCESS MORTALITY;
   PSYCHIATRIC-DISORDERS
AB Objective: To investigate the association between mood and anxiety disorders and vascular diseases after controlling for vascular disease risk factors. Methods: Using a nationally representative sample of adults (N=5692) from the National Comorbidity Survey-Replication (NCS-R), participants with mood disorders were hierarchically classified as having any lifetime history of mania, hypomania, or major depression. Anxiety disorders were also assessed. The reference group consisted of those without mental disorders. Vascular disease was determined by self-reported history of heart disease, heart attack, or stroke on the NCS-R survey. Vascular risk factors included diabetes, high blood pressure, and obesity. Results: In multivariate logistic regression models that controlled for obesity, high blood pressure, smoking and diabetes, vascular disease was associated with bipolar disorder in women [odds ratio (OR) 2.80, 95% confidence interval (CI) 1.63-4.80], and major depressive disorder in men (OR 1.85, 95% CI 1.17-2.92). Controlling for anxiety disorders reduced the associations in both men and women, and in fact, anxiety disorders were more strongly associated with vascular diseases in men, whereas bipolar disorder continued to be an important correlate of vascular disease in women. Conclusion: These findings demonstrate the importance of evaluation of sex differences, mood disorder subtype and co-occurring anxiety disorders in assessing the association between mood disorders and vascular diseases. Future research should investigate potential biologic mechanisms for these associations in order to define potential targets for intervention. (C) 2011 Elsevier Inc. All rights reserved.
C1 [Fiedorowicz, Jess G.] Univ Iowa, Dept Psychiat, Roy J & Lucille A Carver Coll Med, Hosp & Clin, Iowa City, IA 52242 USA.
   [Fiedorowicz, Jess G.] Univ Iowa, Dept Epidemiol, Coll Publ Hlth, Iowa City, IA USA.
   [He, Jianping; Merikangas, Kathleen R.] NIMH, Genet Epidemiol Res Branch, Intramural Res Program, Bethesda, MD 20892 USA.
C3 University of Iowa; University of Iowa; National Institutes of Health
   (NIH) - USA; NIH National Institute of Mental Health (NIMH)
RP Fiedorowicz, JG (corresponding author), 200 Hawkins Dr,W278GH, Iowa City, IA 52242 USA.
EM jess-fiedorowicz@uiowa.edu
RI Fiedorowicz, Jess/I-2512-2019; He, JianPing/H-9536-2018
OI Merikangas, Kathkeen/0000-0002-4667-2414; Fiedorowicz,
   Jess/0000-0003-2057-4071
FU Department of Psychiatry at the University of Iowa; National Institute
   of Mental Health; National Institutes of Health [1K23MH083695-01A210];
   NARSAD; Nellie Ball Trust Research Fund; Institute for Clinical and
   Translational Science at the University of Iowa [3 UL1 RR024979-03S4];
   CHDI foundation
FX This work was supported by the Department of Psychiatry at the
   University of Iowa and the Intramural Research Program of the National
   Institute of Mental Health. Dr. Fiedorowicz is supported by the National
   Institutes of Health (1K23MH083695-01A210), NARSAD, the Nellie Ball
   Trust Research Fund, Institute for Clinical and Translational Science at
   the University of Iowa (3 UL1 RR024979-03S4), and CHDI foundation. Dr.
   Fiedorowicz currently serves as a site physician for colleagues' studies
   with Neurosearch, Vitalin/Enzymatic Therapy, and the National Center for
   Complementary and Alternative Medicine/the US Food and Drug
   Administration Orphan Products division.
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NR 70
TC 73
Z9 90
U1 0
U2 12
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-3999
EI 1879-1360
J9 J PSYCHOSOM RES
JI J. Psychosomat. Res.
PD FEB
PY 2011
VL 70
IS 2
BP 145
EP 154
DI 10.1016/j.jpsychores.2010.07.010
PG 10
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 716ET
UT WOS:000286952600006
PM 21262417
OA Green Accepted
DA 2025-06-11
ER

PT S
AU Lin, KG
   Liu, T
AF Lin, Kangguang
   Liu, Tao
BE Yau, SY
   So, KF
TI Exercise on bipolar disorder in humans
SO EXERCISE ON BRAIN HEALTH
SE International Review of Neurobiology
LA English
DT Review; Book Chapter
ID PHYSICAL-ACTIVITY; SEDENTARY BEHAVIOR; PERCEIVED BARRIERS;
   MENTAL-ILLNESS; PEOPLE; DEPRESSION; MORTALITY; SCHIZOPHRENIA;
   INTERVENTIONS; ASSOCIATION
AB People with Bipolar disorder (BD) often have a sedentary lifestyle and low level of physical activity which in part contribute to the high co-occurrence of medical diseases including cardiovascular disease, type 2 diabetes, and metabolic syndrome, etc. Exercise especially aerobic exercise may be beneficial not only to mental health but also physical health outcomes. Targeting barriers for exercise such as high BMI and making the best use of facilitators (e.g., concept of fitness) can result in higher levels of exercise engagement in people with BD.
C1 [Lin, Kangguang; Liu, Tao] Guangzhou Med Univ, Dept Mood Disorders, Affiliated Brain Hosp, Guangzhou, Guangdong, Peoples R China.
C3 Guangzhou Medical University
RP Lin, KG (corresponding author), Guangzhou Med Univ, Dept Mood Disorders, Affiliated Brain Hosp, Guangzhou, Guangdong, Peoples R China.
EM linkangguang@163.com
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NR 51
TC 7
Z9 7
U1 1
U2 7
PU ELSEVIER ACADEMIC PRESS INC
PI SAN DIEGO
PA 525 B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0074-7742
BN 978-0-12-816967-4
J9 INT REV NEUROBIOL
JI Int. Rev. Neurobiol.
PY 2019
VL 147
BP 189
EP 198
DI 10.1016/bs.irn.2019.07.001
PG 10
WC Neurosciences
WE Book Citation Index – Science (BKCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA BO1NS
UT WOS:000501593500008
PM 31607354
DA 2025-06-11
ER

PT J
AU Rebolledo-Solleiro, D
   Roldán-Roldán, G
   Díaz, D
   Velasco, M
   Larqué, C
   Rico-Rosillo, G
   Vega-Robledo, GB
   Zambrano, E
   Hiriart, M
   de la Mora, MP
AF Rebolledo-Solleiro, Daniela
   Roldan-Roldan, Gabriel
   Diaz, Daniel
   Velasco, Myrian
   Larque, Carlos
   Rico-Rosillo, Guadalupe
   Bertha Vega-Robledo, Gloria
   Zambrano, Elena
   Hiriart, Marcia
   Perez de la Mora, Miguel
TI Increased anxiety-like behavior is associated with the metabolic
   syndrome in non-stressed rats
SO PLOS ONE
LA English
DT Article
ID ELEVATED PLUS-MAZE; DEPRESSIVE-LIKE BEHAVIOR; CHRONIC STRESS;
   INDOLEAMINE 2,3-DIOXYGENASE; LEPTIN RESISTANCE; GUT MICROBIOTA; OBESITY;
   DIET; BRAIN; AMYGDALA
AB Metabolic syndrome (MS) is a cluster of signs that increases the risk to develop diabetes mellitus type 2 and cardiovascular disease. In the last years, a growing interest to study the relationship between MS and psychiatric disorders, such as depression and anxiety, has emerged obtaining conflicting results. Diet-induced MS rat models have only examined the effects of high-fat or mixed cafeteria diets to a limited extent. We explored whether an anxiety-like behavior was associated with MS in non-stressed rats chronically submitted to a high-sucrose diet (20% sucrose in drinking water) using three different anxiety paradigms: the shock-probe/burying test (SPBT), the elevated plus-maze (EPM) and the open-field test (OFT). Behaviorally, the high-sucrose diet group showed an increase in burying behavior in the SPBT. Also, these animals displayed both avoidance to explore the central part of the arena and a significant increase in freezing behavior in the OFT and lack of effects in the EPM. Also, high-sucrose diet group showed signs of an MS-like condition: significant increases in body weight and body mass index, abdominal obesity, hypertension, hyperglycemia, hyperinsulinemia, and dyslipidemia. Plasma leptin and resistin levels were also increased. No changes in plasma corticosterone levels were found. These results indicate that rats under a 24-weeks high-sucrose diet develop an MS associated with an anxiety-like behavior. Although the mechanisms underlying this behavioral outcome remain to be investigated, the role of leptin is emphasized.
C1 [Rebolledo-Solleiro, Daniela; Velasco, Myrian; Larque, Carlos; Hiriart, Marcia; Perez de la Mora, Miguel] Univ Nacl Autonoma Mexico, Inst Fisiol Celular, Div Neurosci, Mexico City, DF, Mexico.
   [Roldan-Roldan, Gabriel] Univ Nacl Autonoma Mexico, Fac Med, Dept Fisiol, Lab Neurobiol Conducta, Mexico City, DF, Mexico.
   [Diaz, Daniel] Univ Nacl Autonoma Mexico, Inst Invest Biomed, Dept Biol Cell & Fisiol, Mexico City, DF, Mexico.
   [Rico-Rosillo, Guadalupe; Bertha Vega-Robledo, Gloria] Univ Nacl Autonoma Mexico, Lab Inmunol, Dept Med Expt, Fac Med, Mexico City, DF, Mexico.
   [Zambrano, Elena] Inst Nacl Nutr Salvador Zubiran, Dept Biol Reprod, Mexico City, DF, Mexico.
C3 Universidad Nacional Autonoma de Mexico; Universidad Nacional Autonoma
   de Mexico; Universidad Nacional Autonoma de Mexico; Universidad Nacional
   Autonoma de Mexico; Instituto Nacional de Ciencias Medicas y Nutricion
   Salvador Zubiran - Mexico
RP Rebolledo-Solleiro, D; de la Mora, MP (corresponding author), Univ Nacl Autonoma Mexico, Inst Fisiol Celular, Div Neurosci, Mexico City, DF, Mexico.
EM danyrebolledo@hotmail.com; mperez@ifc.unam.mx
RI Larqué, Carlos/B-3834-2011; Diaz, Daniel/P-1916-2018; Hiriart,
   Marcia/A-3988-2008
OI Zambrano, Elena/0000-0002-0362-9117; Diaz, Daniel/0000-0003-2302-1982;
   Velasco, Myrian/0000-0002-9276-1928; Hiriart,
   Marcia/0000-0001-5711-8868; Larque Velazquez, Carlos
   Alfonso/0000-0003-0634-195X; REBOLLEDO-SOLLEIRO,
   DANIELA/0000-0002-6994-7599; Perez de la Mora,
   Miguel/0000-0003-1520-4439
FU Direccio An General de Asuntos del Personal AcadeAmico, (DGAPA)
   [IN204314, IN204014-3]; Universidad Nacional Autonoma de Mexico (UNAM);
   Consejo Nacional de Cienciay Tecnologia (CONACyT) [CB-2013/220173]
FX This study was supported in part by grants IN204314 and IN204014-3 from
   Direccion General de Asuntos del Personal Academico, (DGAPA),
   Universidad Nacional Autonoma de Mexico (UNAM) and by grant
   CB-2013/220173 from Consejo Nacional de Ciencia y Tecnologia (CONACyT),
   as well as the one given to D.R-S during her graduate studies within the
   program of Doctorado en Ciencias Biomedicas from the Universidad
   Nacional Autonoma de Mexico (UNAM).
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NR 81
TC 34
Z9 35
U1 1
U2 7
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAY 2
PY 2017
VL 12
IS 5
AR e0176554
DI 10.1371/journal.pone.0176554
PG 21
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA ET9RV
UT WOS:000400646300032
OA Green Submitted, gold, Green Published
DA 2025-06-11
ER

PT J
AU Roer, GE
   Lien, LR
   Bolstad, I
   Aaseth, JO
   Abebe, DS
AF Roer, Grethe Emilie
   Lien, Lars
   Bolstad, Ingeborg
   Aaseth, Jan O.
   Abebe, Dawit Shawel
TI The impact of PTSD on risk of cardiometabolic diseases: a national
   patient cohort study in Norway
SO BMC PSYCHIATRY
LA English
DT Article
DE Posttraumatic stress disorder; Alcohol use disorder; Depression;
   Comorbidity; Cardiovascular diseases; Metabolic diseases; Diabetes
   mellitus; Epidemiology; Register data; Cohort study
ID POSTTRAUMATIC-STRESS-DISORDER; MAJOR DEPRESSIVE DISORDER;
   PHYSICAL-ACTIVITY LEVELS; SUBSTANCE USE DISORDERS; METABOLIC SYNDROME;
   EPIDEMIOLOGIC SURVEY; PEOPLE; PREVALENCE; HEALTH; ASSOCIATION
AB BackgroundPosttraumatic stress disorder (PTSD) is associated with cardiometabolic diseases, concurrent anxiety, alcohol use disorder and depression. The relationship between PTSD and cardiometabolic diseases are still unclear, and less is known about the effects of socioeconomic status, comorbid anxiety, comorbid alcohol use disorder and comorbid depression. The study, therefore, aims to examine the risk of developing cardiometabolic diseases including type 2 diabetes mellitus over time in PTSD patients, and to what extent socioeconomic status, comorbid anxiety, comorbid alcohol use disorder and comorbid depression attenuate associations between PTSD and risk of developing cardiometabolic diseases.MethodA retrospective, register-based cohort study with 6-years follow-up of adult (> 18 years) PTSD patients (N = 7 852) compared with the general population (N = 4 041 366), was performed. Data were acquired from the Norwegian Patient Registry and Statistic Norway. Cox proportional regression models were applied to estimate hazard ratios (HRs) (99% confidence intervals) of cardiometabolic diseases among PTSD patients.ResultsSignificantly (p < 0.001) higher age and gender adjusted HRs were disclosed for all cardiometabolic diseases among PTSD patients compared to the population without PTSD, with a variation in HR from 3.5 (99% CI 3.1-3.9) for hypertensive diseases to HR = 6.5 (5.7-7.5) for obesity. When adjusted for socioeconomic status and comorbid mental disorders, reductions were observed, especially for comorbid depression, for which the adjustment resulted in HR reduction of about 48.6% for hypertensive diseases and 67.7% for obesity.ConclusionsPTSD was associated with increased risk of developing cardiometabolic diseases, though attenuated by socioeconomic status and comorbid mental disorders. Health care professionals should be attentive towards the burden and increased risk that low socioeconomic status and comorbid mental disorders may represent for PTSD patients' cardiometabolic health.
C1 [Roer, Grethe Emilie; Lien, Lars; Abebe, Dawit Shawel] Innlandet Hosp Trust, Norwegian Natl Advisory Unit Concurrent Subst Abus, POB 104, NO-2381 Brumunddal, Norway.
   [Roer, Grethe Emilie; Abebe, Dawit Shawel] Oslo Metropolitan Univ, Dept Nursing & Hlth Promot, St Olavs Plass,POB 4, NO-0130 Oslo, Norway.
   [Lien, Lars; Bolstad, Ingeborg; Aaseth, Jan O.] Inland Norway Univ Appl Sci, Fac Social & Hlth Sci, POB 400, NO-2418 Elverum, Norway.
   [Aaseth, Jan O.] Innlandet Hosp Trust, Res Dept, POB 104, NO-2381 Brumunddal, Norway.
C3 Innlandet Hospital Trust; Oslo Metropolitan University (OsloMet); Inland
   Norway University of Applied Sciences; Innlandet Hospital Trust
RP Roer, GE (corresponding author), Innlandet Hosp Trust, Norwegian Natl Advisory Unit Concurrent Subst Abus, POB 104, NO-2381 Brumunddal, Norway.; Roer, GE (corresponding author), Oslo Metropolitan Univ, Dept Nursing & Hlth Promot, St Olavs Plass,POB 4, NO-0130 Oslo, Norway.
EM grethe.emilie.roer@sykehuset-innlandet.no
RI Aaseth, Jan/J-6764-2017
OI Roer, Grethe Emilie/0000-0002-7237-6715; Bolstad,
   Ingeborg/0000-0001-7316-6309
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NR 51
TC 3
Z9 3
U1 0
U2 1
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-244X
J9 BMC PSYCHIATRY
JI BMC Psychiatry
PD MAY 20
PY 2023
VL 23
IS 1
AR 349
DI 10.1186/s12888-023-04866-x
PG 9
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychiatry
GA G6FO8
UT WOS:000990095200001
PM 37210523
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Clackler, RG
   Felton, KB
   Holmes, SA
   Stabinsky, HN
   Yarbrough, NB
   Burmeister, MA
AF Clackler, Raeleigh G.
   Felton, Kardarius B.
   Holmes, Sarah A.
   Stabinsky, Hailey N.
   Yarbrough, Nicholas B.
   Burmeister, Melissa A.
TI Current and Emerging Therapies for Bipolar Disorder
SO US PHARMACIST
LA English
DT Article
AB Bipolar disorder (BD) is a complex and lifelong mental health disorder characterized by episodes of mania, hypomania, and/or depression. Affected individuals are often diagnosed with comorbidities including metabolic syndrome and substance use disorder, and life expectancy is partly reduced by suicidal ideation. Current pharmacotherapies, many of which were serendipitously discovered, sufficiently target aberrant neurotransmission but yield inadequate outcomes and cause burdensome side effects. Alternative treatments with fewer adverse effects are in development. Some alternative pharmacotherapies entail reappropriation of classic drugs, such as ketamine and scopolamine. Nonpharmacologic treatments help individuals develop coping mechanisms, improve medication adherence, and establish mood -stabilizing social rhythms.
C1 [Clackler, Raeleigh G.; Felton, Kardarius B.; Holmes, Sarah A.; Stabinsky, Hailey N.; Yarbrough, Nicholas B.; Burmeister, Melissa A.] William Carey Univ, Sch Pharm, Dept Pharm, Biloxi, MS 39532 USA.
   [Clackler, Raeleigh G.; Felton, Kardarius B.; Holmes, Sarah A.; Stabinsky, Hailey N.; Yarbrough, Nicholas B.; Burmeister, Melissa A.] William Carey Univ, Sch Pharm, Dept Practice & Pharmaceut Sci, Biloxi, MS 39532 USA.
C3 William Carey University; William Carey University
RP Clackler, RG (corresponding author), William Carey Univ, Sch Pharm, Dept Pharm, Biloxi, MS 39532 USA.; Clackler, RG (corresponding author), William Carey Univ, Sch Pharm, Dept Practice & Pharmaceut Sci, Biloxi, MS 39532 USA.
RI Burmeister, Melissa/GSE-2701-2022
NR 0
TC 0
Z9 0
U1 0
U2 1
PU JOBSON PUBLISHING LLC
PI NEW YORK
PA 100 AVE OF THE AMERICAS, NEW YORK, NY 10013-1678 USA
SN 0148-4818
EI 2331-3501
J9 US PHARM
JI US Pharm.
PD MAY
PY 2024
VL 49
IS 5
PG 77
WC Pharmacology & Pharmacy
WE Emerging Sources Citation Index (ESCI)
SC Pharmacology & Pharmacy
GA WC6Q2
UT WOS:001252713200008
DA 2025-06-11
ER

PT J
AU Aishwarya, SK
   Gayathri, B
   Prabu, M
   Renuka, P
   Vinodhini, VM
AF Aishwarya, S. K.
   Gayathri, B.
   Prabu, M.
   Renuka, P.
   Vinodhini, V. M.
TI Hypovitaminosis D Implicated in the Development of Stress, Metabolic
   Syndrome and Hepatic Steatosis among Health Science Undergraduates
   attending a Tertiary Care Institute in Tamil Nadu, India
SO JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH
LA English
DT Article
DE Body mass index; Fatty liver; Stress score; Vitamin D
ID FATTY LIVER-DISEASE; SERUM 25-HYDROXYVITAMIN D; VITAMIN-D DEFICIENCY;
   ASSOCIATION; PREVALENCE; ADULTS; DEPRESSION; GENDER
AB Introduction: Vitamin D deficiency is prevalent worldwide and its association with stress has become an emerging problem. A collection of linked physiological, biochemical, clinical, and metabolic risk factors is known as the Metabolic Syndrome (MS). High stress level is found associated with vitamin D deficiency and features of metabolic syndrome symptoms.Aim: To estimate the prevalence of vitamin D deficiency, perceived stress, metabolic syndrome and hepatic steatosis among health science Undergraduate (UG) students and also to evaluate the association of vitamin D with percieved stress score, calcium, phosphorus, components of metabolic syndrome and indicators of liver steatosis.Materials and Methods: This cross-sectional study was conducted in SRM Medical College, Hospital and Research Centre, Chennai, India, from February 2022 to August 2022. A total of 80 health science UG students in the age group of 19-25 years were included. The parameters included Fasting plasma glucose, Triglycerides (TGL), High Density Lipoprotein Cholesterol (HDLC), Gamma-glutamyl Transferase (GGT), phosphorus, calcium, and a Perceived Stress Scale (PSS) score scale. Data were statistically analysed using Pearson's correlation test and Receiver Operating Characteristic (ROC) curve was used to assess the relationship of vitamin D with stress, metabolic syndrome and liver steatosis.Results: In the present study, majority 56 (70%) had vitamin D deficiency, 23 (28.75%) had insufficiency and 1 (1.25%) had sufficiency. An estimated 6 (7.5%) of students experienced low stress, 63 (78.75%) experienced moderate stress and 11 (13.75%) experienced high perceived stress. Indicators of metabolic syndrome occurred in 13 (16.25%) of the population. Nearly 6 (7.5%) of the participants displayed manifestation of fatty liver. A negative association was found between vitamin D with stress score, Body Mass Index (BMI), waist circumference, Blood Pressure (BP), phosphorus, fasting plasma glucose, TGL, HDLC, GGT, Fatty Liver Index (FLI) score.Conclusion: In the present study, vitamin D deficiency was most prevalent (70%), followed by metabolic syndrome, high stress and hepatic steatosis. Vitamin D showed a negative correlation with stress score, BMI, waist circumference, BP, phosphorous, fasting plasma glucose, TGL, HDLC, GGT and FLI score.
C1 [Aishwarya, S. K.; Gayathri, B.; Prabu, M.; Renuka, P.; Vinodhini, V. M.] SRMIST, SRM Med Coll Hosp & Res Ctr, Dept Biochem, Chennai, Tamil Nadu, India.
   [Vinodhini, V. M.] SRMIST, SRM Med Coll Hosp & Res Ctr, Dept Biochem, Chennai 603203, Tamilnadu, India.
C3 SRM Institute of Science & Technology Chennai; SRM Institute of Science
   & Technology Chennai
RP Vinodhini, VM (corresponding author), SRMIST, SRM Med Coll Hosp & Res Ctr, Dept Biochem, Chennai 603203, Tamilnadu, India.
EM vinodhiv1@srmist.edu.in
RI vinodhini, v.m/ABE-6875-2021
FU Beckmann Coulter
FX The authors thank Beckmann Coulter for their support.
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NR 55
TC 0
Z9 0
U1 0
U2 0
PU PREMCHAND SHANTIDEVI RESEARCH FOUNDATION
PI DELHI
PA 71 JAIN COLONY, VEER NAGAR, DELHI, 110 007, INDIA
SN 2249-782X
EI 0973-709X
J9 J CLIN DIAGN RES
JI J. Clin. Diagn. Res.
PD MAY
PY 2023
VL 17
IS 5
BP BC7
EP BC12
DI 10.7860/JCDR/2023/60452.17809
PG 6
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA H3OP3
UT WOS:000995096400003
OA gold
DA 2025-06-11
ER

PT J
AU Miglioretti, M
   Meroni, C
   Baiardo, G
   Savioli, G
   Velasco, V
AF Miglioretti, Massimo
   Meroni, Claudia
   Baiardo, Giacomo
   Savioli, Gaia
   Velasco, Veronica
TI The perceptions of the causes of cardiac diseases: a taxonomy
SO PSYCHOLOGY & HEALTH
LA English
DT Article
DE Illness Perception Questionnaire; causal attribution; cardiac diseases;
   illness perception
ID ILLNESS PERCEPTIONS; MYOCARDIAL-INFARCTION; HOSPITAL ANXIETY; COGNITIVE
   REPRESENTATION; DEPRESSION; QUESTIONNAIRE; ATTRIBUTIONS; VALIDATION;
   WORK
AB Objective: This study verifies whether the open-ended question of the B-IPQ can collect causal attributions of patients with cardiac diseases, define the more frequent causal attributions reported, classify them and describe the relation between the classification of the causes and patients' characteristics.Design: A group of 2011 patients with cardiac diseases was recruited during the first week of cardiac rehabilitation.Primary outcome measures: Every participant filled in the B-IPQ and the HADS. The qualitative and quantitative analyses of the text using T-LAB identified the most frequent causal attributions and their co-occurrences.Results: Among the patients, 26% did not recognise any causal attribution. The likelihood that the patients did not provide an answer was increased in older patients, females, patients with lower levels of education and higher levels of depression. Smoking and stress emerged as the most important attributions, followed by genetics, metabolic syndrome, work and nutrition. Four thematic clusters were identified: work and stress', metabolic syndrome and hypertension', displeasures and body care' and heredity and other related diseases'.Conclusions: This study suggests a classification of the causal attributions in patients with cardiac diseases and identifies thematic patterns and unknown attributions. The themes identified can serve as categories for future closed-ended questions.
C1 [Miglioretti, Massimo; Meroni, Claudia; Velasco, Veronica] Univ Milano Bicocca, Dept Psychol, Milan, Italy.
   [Baiardo, Giacomo; Savioli, Gaia] Cardiovasc Inst Camogli, Psychol Unit, Ruta Di Camogli, GE, Italy.
C3 University of Milano-Bicocca
RP Miglioretti, M (corresponding author), Univ Milano Bicocca, Dept Psychol, Milan, Italy.
EM massimo.miglioretti@unimib.it
RI Velasco, Veronica/AAK-2836-2020
OI VELASCO, VERONICA/0000-0003-1890-5564
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NR 41
TC 1
Z9 3
U1 1
U2 11
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0887-0446
EI 1476-8321
J9 PSYCHOL HEALTH
JI Psychol. Health
PY 2018
VL 33
IS 4
BP 537
EP 554
DI 10.1080/08870446.2017.1380810
PG 18
WC Public, Environmental & Occupational Health; Psychology,
   Multidisciplinary
WE Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; Psychology
GA FZ4KC
UT WOS:000427560100006
PM 28984484
DA 2025-06-11
ER

PT J
AU Rana, S
   Ali, S
   Wani, HA
   Mushtaq, QD
   Sharma, S
   Rehman, MU
AF Rana, Sanjeev
   Ali, Shafat
   Wani, Hilal Ahmad
   Mushtaq, Qazi Danish
   Sharma, Swarkar
   Rehman, Muneeb U.
TI Metabolic syndrome and underlying genetic determinants-A systematic
   review
SO JOURNAL OF DIABETES AND METABOLIC DISORDERS
LA English
DT Review
DE Metabolic syndrome; Gene polymorphism; Twin; Family; Predisposition;
   Phenotype; Determinants; Linkage
ID C-REACTIVE PROTEIN; INSULIN-RESISTANCE SYNDROME; CORONARY-HEART-DISEASE;
   ACID-BINDING PROTEIN-2; PPAR-GAMMA GENE; INSERTION/DELETION
   POLYMORPHISM; CARDIOVASCULAR-DISEASE; PROVISIONAL REPORT; HISPANIC
   FAMILIES; OXIDATIVE STRESS
AB The metabolic syndrome is a cluster of heritable and related traits which has been associated with a range of pathophysiological factors including dyslipidaemia, abdominal obesity, increased fasting plasma glucose (FPG) and hypertension. The documented genetic basis of the metabolic syndrome include several chromosomal positions, numerous candidate gene-associated polymorphisms, different genetic variants, which are linked to the syndrome either as a trait or entities mainly linked to metabolic process. Additionally, the latest findings related to the contribution of epigenetic mechanisms, microRNAs, sporadic variants, non-coding RNAs, and assessing the role of genes in molecular systems has enhanced our understanding of the syndrome. Considerable work has been done to understand the underlying disease mechanisms by elucidating its genetic etiology. Nonetheless, a common shared genetic cause has not been established to clarify the coexistence of their components and further investigation is required. While mostly neglected and rarely known, hereditary predisposition needs to be studied, including with the current defective phenotypic condition descriptions. Metabolic syndrome is a multi-faceted characteristic with abundant properties and the condition can arise from interactions between environmental variables such as physical inactivity, caloric obesity and genetic susceptibility. Although there is support for genetic determinants from family and twin research, there is still no recognised genomic DNA marker for genetic association and linkages with quite a long way off potential for clinical application. In the present review efforts have been made to through light on the various genetic determinants with large effects that underlie with the association of these traits to this syndrome. The heterogeneity and multifactorial heritability of MetS, however, has been a challenge towards understanding the factors underlying the association of these traits.
C1 [Rana, Sanjeev] Shri Mata Vaishno Devi Univ SMVDU, Human Genom Res Grp, Katra, Jammu & Kashmir, India.
   [Ali, Shafat] Univ Kashmir, Res Dev Ctr, Cytogenet & Mol Biol Lab, Srinagar, India.
   [Wani, Hilal Ahmad] Govt Degree Coll Sumbal, Dept Biochem, Bandipora, Jammu & Kashmir, India.
   [Mushtaq, Qazi Danish] Sri Pratap Coll, Dept Biochem, Srinagar, Jammu & Kashmir, India.
   [Sharma, Swarkar] Shri Mata Vaishno Devi Univ SMVDU, Sch Biotechnol, Human Genom Res Grp, Katra, Jammu & Kashmir, India.
   [Rehman, Muneeb U.] King Saud Univ, Coll Clin Pharm, Riyadh, Saudi Arabia.
C3 Shri Mata Vaishno Devi University; University of Kashmir; Shri Mata
   Vaishno Devi University; King Saud University
RP Wani, HA (corresponding author), Govt Degree Coll Sumbal, Dept Biochem, Bandipora, Jammu & Kashmir, India.; Rehman, MU (corresponding author), King Saud Univ, Coll Clin Pharm, Riyadh, Saudi Arabia.
EM hilalbiochem2007@gmail.com; muneebbjh@gmail.com
RI ALI, SHAFAT/AAG-6507-2021; sharma, swarkar/B-8096-2008
OI Rana, Sanjeev/0000-0001-7607-6931; Ali, Shafat/0000-0001-8403-423X;
   sharma, swarkar/0000-0001-8857-5906
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NR 129
TC 17
Z9 19
U1 1
U2 9
PU SPRINGER INT PUBL AG
PI CHAM
PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND
EI 2251-6581
J9 J DIABETES METAB DIS
JI J. Diabetes Metab. Disord.
PD JUN
PY 2022
VL 21
IS 1
BP 1095
EP 1104
DI 10.1007/s40200-022-01009-z
EA MAR 2022
PG 10
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA 1V2OI
UT WOS:000763824600002
PM 35673448
OA Green Published
DA 2025-06-11
ER

PT J
AU Skogberg, N
   Castaneda, AE
   Agyemang, C
   Koponen, P
   Lilja, E
   Laatikainen, T
AF Skogberg, Natalia
   Castaneda, Anu E.
   Agyemang, Charles
   Koponen, Paivikki
   Lilja, Eero
   Laatikainen, Tiina
TI The association of depressive and anxiety symptoms with the metabolic
   syndrome and its components among Russian, Somali, and Kurdish origin
   adults in Finland: A population-based study
SO JOURNAL OF PSYCHOSOMATIC RESEARCH
LA English
DT Article
DE Metabolic syndrome; Depressive symptoms; Anxiety symptoms; Migrant
ID RISK; METAANALYSIS; MIGRANTS; DISEASE; SWEDEN
AB Objective: Positive association of depressive and anxiety symptoms with the metabolic syndrome (MetS) have been reported, however there is little information on these among migrant origin populations. The aim of this study was to examine these associations among diverse migrant origin populations in Finland. Methods: Data of 318 Russian, 212 Somali, and 321 Kurdish origin participants in the cross-sectional Finnish Migrant Health and Wellbeing Study (Maamu) aged 30-64 years was used. The general population reference group constituted of 786 Health 2011 Survey participants. Depressive and anxiety symptoms were measured with HSCL-25 subscales. Harmonized definition of MetS was used. Results: Depressive symptoms were associated with elevated blood pressure in Kurdish origin (30.1%, 95% CI 22.7-38.8 vs. 19.9%, 95%CI 15.4-25.4 for those with and without symptoms respectively); and elevated waist circumference (72.1%, 95%CI 56.9-83.5 vs. 55.0%, 95%CI 50.6-59.4) and triglycerides (30.8%, 95%CI 16.0-51.0 vs. 11.9%, 95%CI 9.3-15.0) in general population. Anxiety symptoms were associated with MetS (47.0%, 95%CI 37.6-56.7 vs. 31.9%, 95%CI 26.7-37.6) and elevated blood pressure (37.2%, 95%CI 28.3-46.9 vs. 18.8%, 95%CI 14.7-23.6), and with elevated triglycerides in Somali origin (33.0%, 95%CI 14.5-59.0 vs. 5.7%, 95%CI 3.3-9.6) and general population (30.2%, 95%CI 16.4-48.8, 12.8%, 95%CI 9.9-16.2). No associations between low HDL-cholesterol and depressive or anxiety symptoms were observed. Conclusion: Cardiometabolic health should be taken into account in mental health services. Future studies should explore the underlying pathways to the observed differences in strengths of associations of depressive and anxiety symptoms with MetS and its components across diverse migrant origin populations.
C1 [Skogberg, Natalia; Castaneda, Anu E.; Koponen, Paivikki; Lilja, Eero; Laatikainen, Tiina] Finnish Inst Hlth & Welf, Dept Publ Hlth & Welf, Helsinki, Finland.
   [Agyemang, Charles] Univ Amsterdam, Amsterdam Univ Med Ctr, Dept Publ & Occupat Hlth, Amsterdam, Netherlands.
   [Laatikainen, Tiina] Inst Publ Hlth & Clin Nutr, Kuopio, Finland.
   [Laatikainen, Tiina] Joint Municipal Author Social & Hlth Serv Siun Sot, Joensuu, Finland.
   [Skogberg, Natalia] Finnish Inst Hlth & Welf, Mannerheimintie 166,POB 27, Helsinki 00271, Finland.
C3 University of Amsterdam
RP Skogberg, N (corresponding author), Finnish Inst Hlth & Welf, Mannerheimintie 166,POB 27, Helsinki 00271, Finland.
EM natalia.skogberg@thl.fi
RI Laatikainen, Tiina/ABD-6622-2021
OI Skogberg, Natalia/0000-0002-8829-4159
FU Ane and Signe Gyllenberg foundation [5165]; Finnish Cultural Foundation
   (AEC)
FX The authors would like to acknowledge all of the participants in the
   Migrant Health and Wellbeing Study and the Health2011 Survey. This work
   was supported by the Ane and Signe Gyllenberg foundation (NS, grant
   number 5165) and by the Finnish Cultural Foundation (AEC) . The funding
   bodies had no role in study design; in the collection, analysis and
   interpretation of data; in the writing of the report; or in the decision
   to submit the article for publication. The authors would like to thank
   Tyler Prinkey for the help with formatting references and conducting a
   preliminary literature search.
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NR 42
TC 8
Z9 8
U1 4
U2 5
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-3999
EI 1879-1360
J9 J PSYCHOSOM RES
JI J. Psychosomat. Res.
PD AUG
PY 2022
VL 159
AR 110944
DI 10.1016/j.jpsychores.2022.110944
EA MAY 2022
PG 8
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 2G2IL
UT WOS:000813420900007
PM 35605441
OA hybrid
DA 2025-06-11
ER

PT J
AU Stegerhoek, P
   Kooijman, K
   Ziesemer, K
   IJzerman, H
   Kuijer, PPFM
   Verhagen, E
AF Stegerhoek, Pablo
   Kooijman, Karlijn
   Ziesemer, Kirsten
   IJzerman, Herman
   Kuijer, P. Paul F. M.
   Verhagen, Evert
TI Risk factors for adverse health in military and law enforcement
   personnel; an umbrella review
SO BMC PUBLIC HEALTH
LA English
DT Review
DE Health; Risk Factor; Military Personnel; Law Enforcement;
   Musculoskeletal Injury; Mental Health; Chronic Disease
ID POLICE OFFICERS; MUSCULOSKELETAL INJURIES; GENETIC RISK; PREVALENCE;
   OBESITY; STRESS; RESPONDERS; DEPRESSION; BARRIERS; BURNOUT
AB Background A better understanding of adverse health and underlying risk factors in the context of military and law enforcement is essential to developing future preventative strategies. We conducted an umbrella review to provide an overview of the current literature regarding risk factors for adverse health in military and law enforcement populations.
   Methods We systematically searched the literature for systematic reviews and meta-analyses regarding risk factors for adverse health in military or law enforcement populations. We critically appraised the studies that matched our inclusion criteria, extracted the adverse health outcomes and underlying risk factors, and narratively synthesised the findings.
   Results This umbrella review included 34 systematic reviews that covered data from 43 countries. We identified twenty-six adverse health outcomes and 220 underlying risk factors. The adverse health outcomes covered in the included systematic reviews were one infectious disease (Heliobacter pylori infection); two endocrine, nutritional, or metabolic diseases (metabolic syndrome and obesity); seven mental, behavioural, or neurodevelopmental disorders (adjustment disorder, alcohol misuse, anxiety, depression, poor mental health, PTSD, and stress); two diseases of the nervous system (insomnia and sleep-disordered breathing); one disease of the ear or mastoid process (noise-induced hearing loss); eight diseases of the musculoskeletal system and connective tissue (cervical spine injuries, injuries, lower extremity injuries, musculoskeletal injuries, neck pain, rhabdomyolysis, and stress fractures); one symptom, signs and abnormal clinical and laboratory findings, not elsewhere classified (suicidal ideation); three injuries, poisonings, or other consequences of external causes (concussion, heat illness, and suicide); and one factor influencing health status and contact with health services (burnout). Of the 220 identified risk factors, 136 were modifiable, and the most frequently reported were female sex, older age, lower functional movement screen scores, maladaptive coping, lack of social support, and neuroticism.
   Conclusion This umbrella review identified twenty-six adverse health outcomes and their underlying risk factors in military and law enforcement populations. Hereby, this study provides potential starting points for preventing adverse health in these populations. It also identifies a broad lack of systematic reviews investigating mental, behavioural, or neurodevelopmental disorders in military populations and diseases of the musculoskeletal system and connective tissue in law enforcement populations.
   Prospero Registration NumberCRD42022378123.
C1 [Stegerhoek, Pablo; Kooijman, Karlijn; Kuijer, P. Paul F. M.; Verhagen, Evert] Amsterdam UMC, Amsterdam Collaborat Hlth & Safety Sports, Dept Publ & Occupat Hlth, Amsterdam Movement Sci, Amsterdam, Netherlands.
   [Stegerhoek, Pablo; Kuijer, P. Paul F. M.] Univ Amsterdam, Amsterdam UMC, Amsterdam Publ Hlth Res Inst, Dept Publ & Occupat Hlth, Amsterdam, Netherlands.
   [Stegerhoek, Pablo] Acad Med Ctr, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands.
   [Stegerhoek, Pablo; IJzerman, Herman] Royal Netherlands Marechaussee, Hlth Care Sect, Pl Kalvermarkt Complex, Kalvermarkt 32, NL-2511 CB The Hague, Netherlands.
   [Kooijman, Karlijn] Netherlands Inst Study Crime & Law Enforcement, Nederlands Studiecentrum Criminaliteit Rechtshand, Amsterdam, Netherlands.
   [Kooijman, Karlijn] Vrije Univ Amsterdam, Fac Behav & Movement Sci, Dept Human Movement Sci, Amsterdam Movement Sci, Amsterdam, Netherlands.
   [Ziesemer, Kirsten] Vrije Univ, Univ Lib, Med Lib, Amsterdam, Netherlands.
C3 Vrije Universiteit Amsterdam; University of Amsterdam; Vrije
   Universiteit Amsterdam; University of Amsterdam; Vrije Universiteit
   Amsterdam; Vrije Universiteit Amsterdam; Vrije Universiteit Amsterdam
RP Stegerhoek, P (corresponding author), Amsterdam UMC, Amsterdam Collaborat Hlth & Safety Sports, Dept Publ & Occupat Hlth, Amsterdam Movement Sci, Amsterdam, Netherlands.; Stegerhoek, P (corresponding author), Univ Amsterdam, Amsterdam UMC, Amsterdam Publ Hlth Res Inst, Dept Publ & Occupat Hlth, Amsterdam, Netherlands.; Stegerhoek, P (corresponding author), Acad Med Ctr, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands.; Stegerhoek, P (corresponding author), Royal Netherlands Marechaussee, Hlth Care Sect, Pl Kalvermarkt Complex, Kalvermarkt 32, NL-2511 CB The Hague, Netherlands.
EM p.m.stegerhoek@amsterdamumc.nl
RI Verhagen, Evert/A-1502-2013
OI Stegerhoek, Pablo/0000-0001-7636-8395; Kooijman, K./0009-0008-5441-6454
FU Royal Netherlands Marechaussee
FX The Royal Netherlands Marechaussee provided funding for the study.
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NR 113
TC 4
Z9 4
U1 4
U2 6
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2458
J9 BMC PUBLIC HEALTH
JI BMC Public Health
PD NOV 13
PY 2024
VL 24
IS 1
AR 3151
DI 10.1186/s12889-024-20553-2
PG 20
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA U1U1Q
UT WOS:001409721200004
PM 39538210
OA gold, Green Accepted
DA 2025-06-11
ER

PT J
AU Winning, A
   Glymour, MM
   McCormick, MC
   Gilsanz, P
   Kubzansky, LD
AF Winning, Ashley
   Glymour, M. Maria
   McCormick, Marie C.
   Gilsanz, Paola
   Kubzansky, Laura D.
TI Psychological Distress Across the Life Course and Cardiometabolic Risk
   Findings From the 1958 British Birth Cohort Study
SO JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
LA English
DT Article
DE biomarkers; cardiometabolic risk; epidemiology; life course; prospective
   study; psychological distress
ID C-REACTIVE PROTEIN; CARDIOVASCULAR HEALTH; CHILDHOOD; DEPRESSION;
   ADULTHOOD; STRESS; ASSOCIATIONS; DISPARITIES; DISORDERS; TEACHERS
AB BACKGROUND Research suggests cardiovascular and metabolic diseases are influenced by psychological distress in adulthood; however, this research is often limited to adult populations and/or a snapshot measure of distress. Given emerging recognition that cardiometabolic diseases have childhood origins, an important question is whether psychological distress earlier in life influences disease development.
   OBJECTIVES This study sought to assess whether life course patterns of psychological distress assessed from childhood through adulthood predict biomarkers of cardiometabolic risk in adulthood and whether effects of sustained distress differ from more limited exposure.
   METHODS The sample (n = 6,714) consists of members of the 1958 British Birth Cohort Study who completed repeated measures of psychological distress and a biomedical survey at age 45 years. Psychological distress profiles over the life course (no distress, childhood only, adulthood only, or persistent distress) were identified from 6 assessments between ages 7 and 42 years. Cardiometabolic risk was assessed by combining information on 9 biomarkers of immune, cardiovascular, and metabolic system function. Covariate adjusted linear regression models were used to assess associations between distress profiles and cardiometabolic risk.
   RESULTS Compared with those with no distress, cardiometabolic risk was higher among people with psychological distress in childhood only (beta = 0.11, SE = 0.03, p = 0.0002), in adulthood only (beta = 0.09, SE = 0.03, p = 0.007), and persistent across the life course (beta = 0.26, SE = 0.04, p < 0.0001).
   CONCLUSIONS Psychological distress at any point in the life course is associated with higher cardiometabolic risk. This is the first study to suggest that even if distress appears to remit by adulthood, heightened risk of cardiometabolic disease remains. Findings suggest early emotional development may be a target for primordial prevention and for promoting lifelong cardiovascular health. (C) 2015 by the American College of Cardiology Foundation.
C1 [Winning, Ashley; McCormick, Marie C.; Gilsanz, Paola; Kubzansky, Laura D.] Harvard Univ, TH Chan Sch Publ Hlth, Dept Social & Behav Sci, Boston, MA 02115 USA.
   [Glymour, M. Maria] Univ Calif San Francisco, Sch Med, Dept Epidemiol & Biostat, San Francisco, CA USA.
C3 Harvard University; Harvard T.H. Chan School of Public Health;
   University of California System; University of California San Francisco
RP Winning, A (corresponding author), Harvard Univ, TH Chan Sch Publ Hlth, Dept Social & Behav Sci, 677 Huntington Ave,Kresge 7th Floor, Boston, MA 02115 USA.
EM awinning@mail.harvard.edu
RI Glymour, Maria/AEM-8841-2022
OI Glymour, M. Maria/0000-0001-9644-3081
FU Julius B. Richmond Fellowship at the Harvard Center on the Developing
   Child; Martha May Eliot Fund at the Harvard T.H. Chan School of Public
   Health; Yerby Postdoctoral Fellowship; MRC [G1001799, MR/N01104X/1]
   Funding Source: UKRI
FX Dr. Winning was supported by the Julius B. Richmond Fellowship at the
   Harvard Center on the Developing Child, and by the Martha May Eliot Fund
   at the Harvard T.H. Chan School of Public Health. Dr. Gilsanz was
   supported by the Yerby Postdoctoral Fellowship. However, no direct
   funding was received or set aside for the writing of this paper. All
   other authors have reported that they have no relationships relevant to
   the contents of this paper to disclose.
CR Appleton AA, 2011, PSYCHOSOM MED, V73, P295, DOI 10.1097/PSY.0b013e31821534f6
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NR 37
TC 72
Z9 83
U1 0
U2 17
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0735-1097
EI 1558-3597
J9 J AM COLL CARDIOL
JI J. Am. Coll. Cardiol.
PD OCT 6
PY 2015
VL 66
IS 14
BP 1577
EP 1586
DI 10.1016/j.jacc.2015.08.021
PG 10
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Cardiovascular System & Cardiology
GA CS3BI
UT WOS:000361945700009
PM 26429083
OA Bronze
DA 2025-06-11
ER

PT J
AU Gilstrap, LG
   Malhotra, R
   Peltier-Saxe, D
   Slicas, D
   Pineda, E
   Culhane-Hermann, C
   Cook, N
   Fernandez-Golarz, C
   Wood, M
AF Gilstrap, Lauren Gray
   Malhotra, Rajeev
   Peltier-Saxe, Donna
   Slicas, Donna
   Pineda, Eliana
   Culhane-Hermann, Catherine
   Cook, Nakela
   Fernandez-Golarz, Carina
   Wood, Malissa
TI Community-Based Primary Prevention Programs Decrease the Rate of
   Metabolic Syndrome Among Socioeconomically Disadvantaged Women
SO JOURNAL OF WOMENS HEALTH
LA English
DT Article
ID CARDIOVASCULAR-DISEASE; LIFE-STYLE; RISK; ASSOCIATION; PREVALENCE;
   HEALTH; TRENDS
AB Background: Metabolic Syndrome (MetSyn) is one of the strongest predictors of type 2 diabetes (DM2) and cardiovascular disease (CVD). It is associated with a 4- to 10-fold increased risk of DM2 and a 2- to 3-fold increased risk of CVD. Low income and minority women have some of the highest rates of MetSyn. This study examines the effect of a unique, community based, primary prevention program on the rates of MetSyn and health habits.
   Methods: Sixty-four low income and minority women were enrolled in the HAPPY (Health Awareness and Primary Prevention in Your neighborhood) Heart Program in an eastern suburb of Boston. Over these 2 years, patients were evaluated by an interdisciplinary medical team: their primary physician, cardiologist, nutritionist, physical therapist, and health coach. The rate of MetSyn was measured at baseline, year 1, and year 2. Comparisons were made either using the paired t test for normally distributed variables or the Wilcoxon Sign test for non-normal variables.
   Results: The rate of MetSyn fell from 64.7% at baseline to 34.9% at year 1 (p = 0.01) and 28.2% at year 2 (p < 0.001). This was driven by increases in high-density lipoprotein (HDL-C) (p < 0.001) and decreases in blood pressure (p = 0.05). Fasting blood glucose trended down, but the hemoglobin A1c (HbA1c) reached significance (decreasing from 6 to 5.8, p < 0.01). Nutrition and exercise habits trended toward improvement. There were significant decreases in anxiety (p < 0.001), depression (p = 0.006) and stress (p = 0.002).
   Conclusion: This lifestyle intervention program is effective at decreasing MetSyn in a socioeconomically disadvantaged, largely minority, female population. This program also decreases anxiety, stress, and depression among participants.
C1 [Gilstrap, Lauren Gray; Malhotra, Rajeev; Fernandez-Golarz, Carina] Massachusetts Gen Hosp, Dept Med, Boston, MA 02114 USA.
   [Malhotra, Rajeev; Wood, Malissa] Massachusetts Gen Hosp, Div Cardiol, Boston, MA 02114 USA.
   [Peltier-Saxe, Donna; Slicas, Donna; Pineda, Eliana; Culhane-Hermann, Catherine] Massachusetts Gen Hosp, Revere Hlth Ctr, Boston, MA 02114 USA.
   [Cook, Nakela] NHLBI, NIH, Bethesda, MD 20892 USA.
C3 Harvard University; Harvard University Medical Affiliates; Massachusetts
   General Hospital; Harvard University; Harvard University Medical
   Affiliates; Massachusetts General Hospital; Harvard University; Harvard
   University Medical Affiliates; Massachusetts General Hospital; National
   Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood
   Institute (NHLBI)
RP Gilstrap, LG (corresponding author), Massachusetts Gen Hosp, Dept Med, 55 Fruit St, Boston, MA 02114 USA.
EM lgilstrap@partners.org
RI Wood, Malissa/T-3201-2019
OI Malhotra, Rajeev/0000-0003-0120-4630
CR [Anonymous], CHRON DIS PREV HLTH
   [Anonymous], HEART DIS STROK PREV
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NR 35
TC 22
Z9 24
U1 1
U2 11
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-9996
EI 1931-843X
J9 J WOMENS HEALTH
JI J. Womens Health
PD APR
PY 2013
VL 22
IS 4
BP 322
EP 329
DI 10.1089/jwh.2012.3854
PG 8
WC Public, Environmental & Occupational Health; Medicine, General &
   Internal; Obstetrics & Gynecology; Women's Studies
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; General & Internal
   Medicine; Obstetrics & Gynecology; Women's Studies
GA 126FZ
UT WOS:000317599700006
PM 23540328
DA 2025-06-11
ER

PT J
AU Jovanovic, J
   Sarac, I
   Martacic, JD
   Oggiano, GP
   Despotovic, M
   Pokimica, B
   Cupi, B
AF Jovanovic, Jovica
   Sarac, Ivana
   Martacic, Jasmina Debeljak
   Oggiano, Gordana Petrovic
   Despotovic, Marta
   Pokimica, Biljana
   Cupi, Blerim
TI The influence of specific aspects of occupational stress on security
   guards' health and work ability: detailed extension of a previous study
SO ARHIV ZA HIGIJENU RADA I TOKSIKOLOGIJU-ARCHIVES OF INDUSTRIAL HYGIENE
   AND TOXICOLOGY
LA English
DT Article
DE cardiovascular diseases; diabetes; hypertension; metabolic syndrome;
   occupational exposure; psychological stress; sick leave
ID ISCHEMIC-HEART-DISEASE; RIDGE-REGRESSION; SHIFT WORK; PRECARIOUS
   EMPLOYMENT; PROFESSIONAL DRIVERS; DIABETES-MELLITUS; LIPID DISORDERS;
   RISK; ENVIRONMENT; ASSOCIATION
AB In our earlier study of security guards, we showed that higher occupational stress was associated with health impairments (metabolic syndrome, diabetes, hypertension, cardiovascular diseases) and work disability. The aim of this study was to further explore the association of specific occupational stressors with health impairments and work disability parameters in 399 Serbian male security guards (aged 25-65 years). Ridge linear regression analysis revealed that, after controlling for age, body mass index, and smoking status, professional stressors including high demands, strictness, conflict/uncertainty, threat avoidance and underload were significant positive predictors of fasting glucose, triglycerides, total and LDL cholesterol, blood pressure, heart rate, Framingham cardiovascular risk score, and temporary work disability. The security profession is in expansion worldwide, and more studies are needed to establish precise health risk predictors, since such data are generally lacking.
C1 [Jovanovic, Jovica; Cupi, Blerim] Univ Nis, Fac Med, Dept Occupat Hlth, Nish, Serbia.
   [Sarac, Ivana; Martacic, Jasmina Debeljak; Oggiano, Gordana Petrovic; Despotovic, Marta; Pokimica, Biljana] Univ Belgrade, Ctr Res Excellence Field Nutr & Metab, Inst Med Res, Natl Inst Republ Serbia, Tadeusa Koscuska 1, Belgrade 11158, Serbia.
   [Jovanovic, Jovica] Inst Occupat Med, Nish, Serbia.
C3 University of Nis; University of Belgrade
RP Sarac, I (corresponding author), Univ Belgrade, Ctr Res Excellence Field Nutr & Metab, Inst Med Res, Natl Inst Republ Serbia, Tadeusa Koscuska 1, Belgrade 11158, Serbia.
EM ivanasarac@yahoo.com
RI Šarac, Ivana/ABR-2387-2022
OI Sarac, Ivana/0000-0003-1439-9561; Despotovic, Marta/0000-0003-0907-3532;
   Debeljak Martacic, Jasmina/0000-0002-9605-3793
FU Ministry of Education, Science and Technological Development of the
   Republic of Serbia [III41030, III43012, 451-03-68/2020-14/200015]
FX The authors acknowledge financial support from the Ministry of
   Education, Science and Technological Development of the Republic of
   Serbia, projects number III41030 and III43012 (2011-2017), and ongoing
   contract number: 451-03-68/2020-14/200015.
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NR 116
TC 5
Z9 6
U1 2
U2 10
PU SCIENDO
PI WARSAW
PA BOGUMILA ZUGA 32A, WARSAW, MAZOVIA, POLAND
SN 0004-1254
EI 1848-6312
J9 ARH HIG RADA TOKSIKO
JI Arh. Hig. Rada. Toksikol.
PD DEC
PY 2020
VL 71
IS 4
BP 359
EP 374
DI 10.2478/aiht-2020-71-3379
PG 16
WC Public, Environmental & Occupational Health; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health; Toxicology
GA PP4OI
UT WOS:000605843200009
PM 33410781
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Robson, PJ
   Guy, GW
   Di Marzo, V
AF Robson, P. J.
   Guy, G. W.
   Di Marzo, V.
TI Cannabinoids and Schizophrenia: Therapeutic Prospects
SO CURRENT PHARMACEUTICAL DESIGN
LA English
DT Article
DE Phytocannabinoids; endocannabinoid system; schizophrenia;
   anti-psychotic; metabolic effects; chronic inflammation; stress
ID PLASMA ENDOCANNABINOID LEVELS; CARDIOMETABOLIC RISK-FACTORS;
   CORONARY-ARTERY-DISEASE; PITUITARY-ADRENAL AXIS; LONG-TERM TREATMENT;
   NEUROTROPHIC FACTOR; METABOLIC SYNDROME; DIABETES-MELLITUS; CB1
   RECEPTORS; ATYPICAL ANTIPSYCHOTICS
AB Approximately one third of patients diagnosed with schizophrenia do not achieve adequate symptom control with standard antipsychotic drugs (APs). Some of these may prove responsive to clozapine, but non-response to APs remains an important clinical problem and cause of increased health care costs.
   In a significant proportion of patients, schizophrenia is associated with natural and iatrogenic metabolic abnormalities (obesity, dyslipidaemia, impaired glucose tolerance or type 2 diabetes mellitus), hyperadrenalism and an exaggerated HPA response to stress, and chronic systemic inflammation.
   The endocannabinoid system (ECS) in the brain plays an important role in maintaining normal mental health. ECS modulates emotion, reward processing, sleep regulation, aversive memory extinction and HPA axis regulation. ECS overactivity contributes to visceral fat accumulation, insulin resistance and impaired energy expenditure.
   The cannabis plant synthesises a large number of pharmacologically active compounds unique to it known as phytocannabinoids. In contrast to the euphoric and pro-psychotic effects of delta-9-tetrahydrocannabinol (THC), certain non-intoxicating phytocannabinoids have emerged in pre-clinical and clinical models as potential APs. Since the likely mechanism of action does not rely upon dopamine D-2 receptor antagonism, synergistic combinations with existing APs are plausible.
   The anti-inflammatory and immunomodulatory effects of the non-intoxicating phytocannabinoid cannabidiol (CBD) are well established and are summarised below. Preliminary data reviewed in this paper suggest that CBD in combination with a CB1 receptor neutral antagonist could not only augment the effects of standard APs but also target the metabolic, inflammatory and stress-related components of the schizophrenia phenotype.
C1 [Robson, P. J.; Guy, G. W.; Di Marzo, V.] GW Pharmaceut Plc, Salisbury SP4 0JQ, Wilts, England.
   [Robson, P. J.] Univ Oxford, Warneford Hosp, Dept Psychiat, Oxford OX3 7JX, England.
   [Di Marzo, V.] CNR, Inst Biomol Chem, Endocannabinoid Res Grp, I-80078 Pozzuoli, NA, Italy.
C3 University of Oxford; Consiglio Nazionale delle Ricerche (CNR)
RP Robson, PJ (corresponding author), GW Pharmaceut Plc, Cannabinoid Res Inst, Porton Sci Pk, Salisbury SP4 0JQ, Wilts, England.
EM pjr@gwpharm.com
RI Di Marzo, Vincenzo/AAD-7742-2019
OI Di Marzo, Vincenzo/0000-0002-1490-3070
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NR 155
TC 20
Z9 22
U1 1
U2 40
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1381-6128
EI 1873-4286
J9 CURR PHARM DESIGN
JI Curr. Pharm. Design
PD APR
PY 2014
VL 20
IS 13
BP 2194
EP 2204
DI 10.2174/13816128113199990427
PG 11
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA AH3UO
UT WOS:000336051300010
PM 23829368
DA 2025-06-11
ER

PT J
AU Marculescu, F
   Antonia, R
   Albulescu, D
   Popescu, M
   Tutunaru, C
   Patrascommacu, V
AF Marculescu, Florentina
   Antonia, Radu
   Albulescu, Dana
   Popescu, Mihaela
   Tutunaru, Cristina
   Patrascommacu, Virgil
TI PREVALENCE OF PSYCHIATRIC COMORBIDITIES IN PATIENTS WITH PSORIASIS AND
   THEIR EVOLUTION UNDER TREATMENT
SO FARMACIA
LA English
DT Article
DE psoriasis; depression; anxiety; treatment
ID STRUCTURED INTERVIEW GUIDE; PANIC DISORDER; DEPRESSION; MELATONIN;
   ANXIETY; DISEASE; IMPACT; LIFE
AB Psoriasis is a chronic, immune-mediated inflammatory dermatosis that associates a number of conditions such as cardiovascular disease, metabolic syndrome, inflammatory bowel disease, neoplasia or psychiatric disorders, amongst the most frequent being depression and anxiety. This article aims to highlight the common pathogenetic pathway between psoriasis and psychiatric comorbidities, depression and anxiety, their prevalence among psoriasis patients, as well as the evolution of these conditions under psoriasis-specific systemic therapy (biological therapy and conventional systemic therapy) using specific scales to quantify depression severity and anxiety (HAM-D, HAM-A), determined at a certain time interval after the initiation of therapies. We conducted an observational study in the Dermatology Department of the Slatina Emergency County Hospital on a group of 51 patients clinically diagnosed with psoriasis. Thus, we found that the degree of mental impairment in the studied group was significant, 49% of patients showed mild depression, 15.7% moderate depressive episodes and 5.9% severe depression. Only 29.4% were not affected by depression. In terms of anxiety, 21.6% had moderate anxiety. Psoriasis is a chronic condition associated with the secretion of numerous pro-inflammatory cytokines. Increased levels of pro-inflammatory cytokines are also found in major depressive disorders. Thus, the common pathogenic pathway between psoriasis and depression may be the overexpression of proinflammatory cytokines such as IL-6, IL-17 or TNF-alpha. In the last two decades, with the advent of biological therapies, the treatment of psoriasis has evolved dramatically, and they have also had a positive impact on comorbidities, particularly psychiatric ones.
C1 [Marculescu, Florentina; Tutunaru, Cristina; Patrascommacu, Virgil] Univ Med & Pharm Craiova, Dept Dermatol, Craiova, Romania.
   [Marculescu, Florentina] Emergency Cty Hosp, Dept Dermatol, Slatina, Romania.
   [Antonia, Radu] Univ Med & Pharm Craiova, Dept Pharmaceut Bot, Craiova, Romania.
   [Albulescu, Dana] Univ Med & Pharm Craiova, Dept Radiol, Craiova, Romania.
   [Popescu, Mihaela] Univ Med & Pharm Craiova, Dept Endocrinol, Craiova, Romania.
   [Tutunaru, Cristina; Patrascommacu, Virgil] Emergency Cty Hosp, Dept Dermatol, Craiova, Romania.
C3 University of Medicine & Pharmacy of Craiova; University of Medicine &
   Pharmacy of Craiova; University of Medicine & Pharmacy of Craiova;
   University of Medicine & Pharmacy of Craiova
RP Albulescu, D (corresponding author), Univ Med & Pharm Craiova, Dept Radiol, Craiova, Romania.
EM dana.albulescu@umfcv.ro
RI Popescu, Sanda/B-9014-2011; albulescu, dana/AAS-9895-2020
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NR 43
TC 1
Z9 1
U1 0
U2 2
PU SOC STIINTE FARMACEUTICE ROMANIA
PI BUCURESTI
PA BUCURESTI, STR TRAIAN VUIA 6, SECT 1, BUCURESTI, 020956, ROMANIA
SN 0014-8237
EI 2065-0019
J9 FARMACIA
JI Farmacia
PD JAN-FEB
PY 2023
VL 71
IS 1
BP 185
EP 193
DI 10.31925/farmacia.2023.1.21
PG 9
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA N3ME0
UT WOS:001036085900016
OA gold
DA 2025-06-11
ER

PT J
AU Meng, XD
   Han, LH
   Fu, JJ
   Hu, CY
   Lu, Y
AF Meng, Xudong
   Han, Liuhu
   Fu, Jiajing
   Hu, Chengyang
   Lu, Yao
TI Associations between metabolic syndrome and depression, and the
   mediating role of inflammation: Based on the NHANES database
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
ID METAANALYSIS; HEALTH
AB Background: Individuals with metabolic syndrome (MetS) have an increased risk of depressive symptoms, with inflammation hypothesized to mediate ation. This study used data from the National Health and Nutrition Examination Survey (NHANES) (2015-2020) to investigate the relationship between depression and assess the mediating role of inflammatory markers. Methods: This cross-sectional study included 20,520 participants. MetS was defined using the NCEP ATP III criteria. Depressive symptoms were assessed Patient Health Questionnaire-9 (PHQ-9), with scores >= 10 indicating clinical significance. Inflammatory markers evaluated included C-reactive protein blood cell count (WBC), and neutrophil-to-lymphocyte ratio (NLR), among others. Multivariable linear and logistic regression models were applied associations, and mediation analysis was conducted to evaluate the potential mediating effects. Results: Overall, 7.64 % of participants exhibited depressive symptoms. MetS was associated with an increased risk of depression in both females (OR: 1.49, 1.28-1.74) and males (OR: 1.32, 95 % CI: 1.09-1.60) after adjusting for confounders. Among MetS components, central obesity, hypertension, and demonstrated the strongest associations with depression. Inflammatory markers mediated 26.79 % of the MetS-depression relationship, with CRP contributing largest proportion (17.24 %). Conclusion: MetS and its components significantly increase the risk of depressive symptoms, with the relationship partially mediated by inflammatory Chronic inflammation may play a critical role in linking MetS to depression, underscoring the importance of integrated management strategies targeting metabolic and mental health.
C1 [Meng, Xudong; Han, Liuhu; Fu, Jiajing; Lu, Yao] Anhui Med Univ, Affiliated Hosp 1, Dept Anesthesiol, Hefei 230022, Peoples R China.
   [Hu, Chengyang] Anhui Med Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Hefei 230032, Peoples R China.
   [Lu, Yao] Anhui Med Univ, Affiliated Hosp 1, Ambulatory Surg Ctr, Hefei 230022, Peoples R China.
C3 Anhui Medical University; Anhui Medical University; Anhui Medical
   University
RP Lu, Y (corresponding author), Anhui Med Univ, Affiliated Hosp 1, Dept Anesthesiol, Hefei 230022, Peoples R China.; Hu, CY (corresponding author), Anhui Med Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Hefei 230032, Peoples R China.
EM cy.hu@ahmu.edu.cn; luyao@ahmu.edu.cn
FU Natural Science Research Project of Anhui Educational Committee
   [2023AH053320]; Key Research Project of Anhui Provincial Health
   Commission [AHWJ2022a007]; Research Fund of Anhui Institute of
   Translational Medicine [2023zhyx-C42]
FX This study was supported by the Natural Science Research Project of
   Anhui Educational Committee (2023AH053320) , Key Research Project of
   Anhui Provincial Health Commission (AHWJ2022a007) , and Research Fund of
   Anhui Institute of Translational Medicine (2023zhyx-C42) .
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NR 29
TC 1
Z9 1
U1 27
U2 27
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD APR 15
PY 2025
VL 375
BP 214
EP 221
DI 10.1016/j.jad.2025.01.108
EA JAN 2025
PG 8
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA X0F7O
UT WOS:001422222500001
PM 39862983
DA 2025-06-11
ER

PT J
AU Katsarou, AL
   Triposkiadis, F
   Panagiotakos, D
AF Katsarou, Alexia L.
   Triposkiadis, Filippos
   Panagiotakos, Demosthenes
TI Perceived Stress and Vascular Disease: Where Are We Now?
SO ANGIOLOGY
LA English
DT Review
DE acute coronary symptoms; coronary heart disease; cardiovascular disease;
   perceived stress; stress perception
ID CORONARY-HEART-DISEASE; CARDIOVASCULAR-DISEASE; MYOCARDIAL-INFARCTION;
   PSYCHOLOGICAL STRESS; METABOLIC SYNDROME; RISK-FACTORS; PSYCHOSOCIAL
   FACTORS; 52 COUNTRIES; MORTALITY; MEN
AB Apart from traditional risk factors, psychosocial characteristics are increasingly considered as potential predictors of cardiovascular disease (CVD). The concept of stress is relevant when discussing the relationship between psychosocial factors and CVD. Among stress types and definitions (ie, marital stress, work stress), perceived stress presents a global and comprehensive stress construct and is based on the concept that individuals actively interact with their environment, appraising potentially threatening or challenging events in the light of available coping resources. However, the role of perceived stress in CVD incidence has not yet been completely elucidated. Thus, we evaluate perceived stress as a CVD risk factor by reviewing the literature. We also discuss the relationship between negative affect and CVD development.
C1 [Katsarou, Alexia L.; Triposkiadis, Filippos] Univ Thessaly, Dept Cardiol, Sch Med, Larisa 41222, Greece.
   [Panagiotakos, Demosthenes] Univ Athens, Grp Biostat Epidemiol & Res Methods, Dept Nutr & Dietet, Athens, Greece.
C3 University of Thessaly; National & Kapodistrian University of Athens
RP Katsarou, AL (corresponding author), Univ Thessaly, Dept Cardiol, Sch Med, 6 Giannitsioti St, Larisa 41222, Greece.
EM katsaroualexia@gmail.com
RI Panagiotakos, Demosthenes/K-8294-2019
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NR 46
TC 22
Z9 26
U1 7
U2 59
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0003-3197
EI 1940-1574
J9 ANGIOLOGY
JI Angiology
PD OCT
PY 2013
VL 64
IS 7
BP 529
EP 534
DI 10.1177/0003319712458963
PG 6
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Cardiovascular System & Cardiology
GA 208MP
UT WOS:000323683500009
PM 22969163
DA 2025-06-11
ER

PT J
AU Grover, S
   Nebhinani, N
   Chakrabarti, S
   Avasthi, A
AF Grover, Sandeep
   Nebhinani, Naresh
   Chakrabarti, Subho
   Avasthi, Ajit
TI Prevalence of metabolic syndrome among patients with depressive disorder
   admitted to a psychiatric inpatient unit: A comparison with healthy
   controls
SO ASIAN JOURNAL OF PSYCHIATRY
LA English
DT Article
DE Metabolic syndrome; Metabolic abnormalities; Depression; Healthy
   controls; India
ID MAJOR DEPRESSION; MENTAL-ILLNESS; YOUNG-ADULTS; SYMPTOMS; ANXIETY;
   OBESITY; RISK; ASSOCIATION; MORTALITY; CARE
AB Objective: This study aimed to compare the prevalence of metabolic syndrome (MS) among inpatients with depressive disorders and matched healthy controls.
   Method: One hundred fifty eight patients with depressive disorders and 52 age and gender matched healthy controls were assessed for the prevalence of MS using Common Criteria for MS.
   Results: Prevalence of Metabolic syndrome among inpatients with depressive disorders was 44.3%, which was significantly higher than the healthy control group (17.3%). Increased waist circumference was the most common abnormality in both the groups. Prevalence of MS among patients with recurrent depression disorder (60.3%) was almost double that seen among those with first episode depression (32.6%). Compared to healthy controls, significantly greater proportion of patients with depressive disorders had increased blood pressure, abnormal fasting blood sugar, and HDL levels. Besides the prevalence of MS in 44.3% of patients with depressive disorders, another 46% of patients fulfilled one or two criteria of MS. Significant predictors of MS were being married, obese, greater age, higher weight, higher body mass index, and multiple episodes of depression.
   Conclusions: Nearly two-fifth of depressed patients have MS and another two-fifth of patients had one or two abnormalities in the MS criteria. The prevalence of MS among patients with depressive disorders is significantly higher than the healthy controls. Hence, patients with depressive disorders should be regularly evaluated for the presence of MS and other cardiovascular risk factors and appropriate management strategies must be instituted at the earliest. (C) 2017 Elsevier B.V. All rights reserved.
C1 [Grover, Sandeep; Chakrabarti, Subho; Avasthi, Ajit] Post Grad Inst Med Educ & Res, Dept Psychiat, Chandigarh 160012, India.
   [Nebhinani, Naresh] AIIMS, Dept Psychiat, Jodhpur, Rajasthan, India.
C3 Post Graduate Institute of Medical Education & Research (PGIMER),
   Chandigarh; All India Institute of Medical Sciences (AIIMS) Jodhpur
RP Grover, S (corresponding author), Post Grad Inst Med Educ & Res, Dept Psychiat, Chandigarh 160012, India.
EM drsandeepg2002@yahoo.com
OI Grover, Sandeep/0000-0002-2714-2055; chakrabarti,
   subho/0000-0001-6023-2194
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NR 47
TC 13
Z9 13
U1 1
U2 2
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1876-2018
EI 1876-2026
J9 ASIAN J PSYCHIATR
JI Asian J. Psychiatr.
PD JUN
PY 2017
VL 27
BP 139
EP 144
DI 10.1016/j.ajp.2017.02.030
PG 6
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychiatry
GA FB3GS
UT WOS:000406031500026
PM 28558888
DA 2025-06-11
ER

PT J
AU Deschênes, SS
   Kivimaki, M
   Schmitz, N
AF Deschenes, Sonya S.
   Kivimaki, Mika
   Schmitz, Norbert
TI Adverse Childhood Experiences and the Risk of Coronary Heart Disease in
   Adulthood: Examining Potential Psychological, Biological, and Behavioral
   Mediators in the Whitehall II Cohort Study
SO JOURNAL OF THE AMERICAN HEART ASSOCIATION
LA English
DT Article
DE adverse childhood experiences; coronary heart disease; health behaviors;
   mental health; metabolic dysregulations
ID BRITISH CIVIL-SERVANTS; PHYSICAL-ACTIVITY; CARDIOVASCULAR-DISEASE;
   METABOLIC SYNDROME; FOLLOW-UP; SLEEP; METAANALYSIS; DEPRESSION;
   DISORDERS; ANXIETY
AB Background
   This study investigated potential psycho-bio-behavioral mediators of the association between adverse childhood experiences (ACEs) and the risk of coronary heart disease (CHD) in adulthood.
   Methods and Results
   Participants were 5610 British civil servants (mean age, 55.5; 28% women) from the Whitehall II cohort study without CHD at baseline in 1997 to 1999 (wave 5) when retrospective data on the number of ACEs were collected via questionnaire (range, 0-8). Potential mediators assessed at wave 5 included depression and anxiety symptoms, health behaviors (smoking, alcohol dependence, sleep, and physical activity), and cardiometabolic dysregulations. New diagnoses of CHD (myocardial infarction, definite angina, coronary artery bypass grafting, or percutaneous transluminal coronary angioplasty) were assessed from wave 6 (2001) to wave 11 (2012-2013). Logistic regressions examined associations between ACEs, potential mediators, and CHD during the follow-up period. Natural indirect effects were examined using mediation analysis. A total of 566 (10.1%) participants developed CHD during the follow-up period. ACEs were associated with an increased likelihood of CHD (odds ratio per ACE, 1.09; 95% CI, 1.00-1.19). Controlling for age and sex, mediation analyses revealed an indirect effect of depression symptoms (natural indirect effects, 1.05; 95% CI, 1.03-1.07), anxiety symptoms (natural indirect effects, 1.12; 95% CI, 1.10-1.15), and a greater number of cardiometabolic dysregulations (natural indirect effects, 1.02; 95% CI, 1.01-1.03) in the association between ACEs and incident CHD. Behavioral factors were not statistically significant mediators.
   Conclusions
   Depression symptoms, anxiety symptoms, and cardiometabolic dysregulations partially mediated the association between ACEs and CHD. Regular screening and treatment of symptoms of psychological disorders and cardiometabolic dysregulations may help mitigate the long-term health burden of ACEs.
C1 [Deschenes, Sonya S.] Univ Coll Dublin, Sch Psychol, Dublin, Ireland.
   [Kivimaki, Mika] UCL, Dept Epidemiol & Publ Hlth, London, England.
   [Schmitz, Norbert] McGill Univ, Dept Psychiat, Montreal, PQ, Canada.
   [Schmitz, Norbert] Douglas Mental Hlth Univ Inst, Montreal, PQ, Canada.
   [Schmitz, Norbert] Univ Tubingen, Med Univ Hosp Tubingen, Dept Populat Based Med, Tubingen, Germany.
C3 University College Dublin; University of London; University College
   London; McGill University; Eberhard Karls University of Tubingen;
   Eberhard Karls University Hospital
RP Deschênes, SS (corresponding author), Univ Coll Dublin, UCD Sch Psychol, Newman Bldg,Stillorgan Rd, Dublin 4, Ireland.
EM sonya.deschenes@ucd.ie
RI Deschenes, Sonya/G-6341-2017; Kivimaki, Mika/B-3607-2012
OI Kivimaki, Mika/0000-0002-4699-5627; Deschenes, Sonya/0000-0002-9258-0895
FU Medical Research Council [K013351, R024227]; British Heart Foundation
   [RG/13/2/30098]; National Institute on Aging (National Institutes of
   Health) [R01AG056477, R01AG062553]; UK Medical Research Council
   [K013351, R024227, S011676]; NordForsk [75021]; Academy of Finland
   [311492]; Helsinki Institute of Life Science [H970]
FX The Whitehall II study is supported by grants from the Medical Research
   Council (K013351, R024227), the British Heart Foundation
   (RG/13/2/30098), and the National Institute on Aging (National
   Institutes of Health, R01AG056477, R01AG062553). Dr Kivimaki was
   supported by the UK Medical Research Council (K013351, R024227,
   S011676), the National Institute on Aging (National Institutes of
   Health, R01AG056477, R01AG062553), NordForsk (75021), the Academy of
   Finland (311492), and Helsinki Institute of Life Science (H970).
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NR 64
TC 34
Z9 36
U1 2
U2 25
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
EI 2047-9980
J9 J AM HEART ASSOC
JI J. Am. Heart Assoc.
PD MAY 18
PY 2021
VL 10
IS 10
AR e019013
DI 10.1161/JAHA.120.019013
PG 12
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Cardiovascular System & Cardiology
GA SD5SR
UT WOS:000651436300010
PM 33938232
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Brillante, DG
   O'Sullivan, AJ
   Brillante, RE
   Howes, LG
AF Brillante, Divina Gracilla
   O'Sullivan, Anthony John
   Brillante, Ruby Esmeralda
   Howes, Laurence Guy
TI Effects of cardiovascular angiotensin II type 1 receptor blockade on
   nitric oxide synthase inhibition in patients with insulin resistance
   syndrome
SO BLOOD PRESSURE
LA English
DT Article
DE Arterial stiffness; AT(1) receptor; digital photoplethysmography;
   haemodynamics; insulin resistance syndrome; telmisartan
ID ENDOTHELIUM-DEPENDENT VASODILATION; ARTERIAL STIFFNESS; METABOLIC
   SYNDROME; DIABETES-MELLITUS; OXIDATIVE STRESS; BLOOD-PRESSURE;
   EXPRESSION; CORONARY; GLUCOSE; NO
AB Background. There is evidence that in the early stages of type 11 diabetes, the cardiovascular system compensates by increasing endothelial nitric oxide synthase (e-NOS) expression. In the advanced stages of disease, e-NOS is diminished, and is associated with endothelial dysfunction. Angiotensin H, acting via the angiotensin II type I (AT(1)) receptor, is central to the development of endothelial dysfunction. The effect of AT(1) receptor blockade on NOS expression and activity in humans with early insulin resistance syndrome (INSR) has not been previously investigated. Eight subjects with INSR participated in a randomized, double-blind, placebo-controlled, crossover study. Subjects were randomized to receive telmisartan or placebo (I month of each) in a two-period crossover study with a 1-week washout period in between. The arterial stiffness and haemodynamic response to intravenous L-nitro-monomethyl arginine (L-NMMA 3 mg/kg) was assessed at baseline and at the end of each treatment phase. SI (Stiffness index, a measure of large artery stiffness) and RI (Reflection index, small-to medium-sized arterial stiffness) were measured using digital photoplethysmography. Haemodynamic parameters [Heart rate (HR), Systolic blood pressure (SBP), Diastolic BP (DBP) and Systemic vascular resistance index (SVRI)] were measured non-invasively using trans-thoracic bioimpedance. Results. Telmisartan significantly reduced baseline SI, SBP, DBP and SVRI. Infusion of L-NMMA produced a significant increase in RI and a significant reduction in HR during placebo therapy. Telmisartan therapy attenuated these responses. Conclusion. Telmisartan therapy reduced NOS activity and/or expression in these subjects, possibly because of improved vascular function arising from AT(1) receptor blockade.
C1 [Howes, Laurence Guy] Griffith & Bond Univ, Sch Med, Dept Cardiol, Gold Coast Hosp, Southport, Qld 4215, Australia.
   [Brillante, Divina Gracilla; O'Sullivan, Anthony John] Univ New S Wales, Dept Med, St George Clin Sch, Kogarah, NSW, Australia.
   [Brillante, Ruby Esmeralda] Concord Hosp, Dept Resp & Sleep Med, Sydney, NSW, Australia.
C3 Griffith University; Griffith University - Gold Coast Campus; Gold Coast
   University Hospital; Bond University; University of New South Wales
   Sydney; Concord Repatriation General Hospital
RP Howes, LG (corresponding author), Griffith & Bond Univ, Sch Med, Dept Cardiol, Gold Coast Hosp, Nerang St, Southport, Qld 4215, Australia.
EM Laurie_Howes@health.qld.gov.au
RI Howes, Laurence/M-4551-2019
OI Howes, Laurence/0000-0002-1507-8260
FU Royal Australasian College of Physicians Research Foundation; National
   Health and Medical Research Council (NHMRC),Australia
FX Dr Brillante received a scholarship from the Royal Australasian College
   of Physicians Research Foundation and the National Health and Medical
   Research Council (NH&MRC),Australia. Boehringer-Ingelheim provided the
   active Telmisartan tablets and donated $5000 to the University of New
   South Wales to aid in the purchase of consumables for this project, and
   were not involved in the design, conduct and writing up of the study.
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NR 42
TC 2
Z9 2
U1 0
U2 3
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
EI 1651-1999
J9 BLOOD PRESSURE
JI Blood Pressure
PY 2009
VL 18
IS 3
BP 142
EP 148
DI 10.1080/08037050902982284
PG 7
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 478FP
UT WOS:000268573500010
PM 19462315
OA Bronze
DA 2025-06-11
ER

PT J
AU Huang, CI
   Lin, LC
   Tien, HC
   Que, J
   Ting, WC
   Chen, PC
   Wu, HM
   Ho, CH
   Wang, JJ
   Wang, RH
   Yang, CC
AF Huang, Chung-I
   Lin, Li-Ching
   Tien, Hung-Cheng
   Que, Jenny
   Ting, Wei Chen
   Chen, Po-Chun
   Wu, Hsin-Min
   Ho, Chung-Han
   Wang, Jhi-Joung
   Wang, Ren-Hong
   Yang, Ching-Chieh
TI Hyperlipidemia and statins use for the risk of new-onset
   anxiety/depression in patients with head and neck cancer: A
   population-based study
SO PLOS ONE
LA English
DT Article
ID QUALITY-OF-LIFE; CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; DEPRESSION;
   ANXIETY; INFLAMMATION; METAANALYSIS; MORTALITY; SYMPTOMS
AB Objective
   Anxiety/depression is common among patients with head and neck cancer (HNC), and can negatively affect treatment compliance and outcome. The aim of this study was to assess the association between hyperlipidemia and the risk of new-onset anxiety/depression after the diagnosis of HNC and the influence of administering statins.
   Methods
   A matched longitudinal cohort study of 1632 subjects (408 HNC patients with preexisting hyperlipidemia and 1224 age- and sex-matched HNC patients without hyperlipidemia) was included and analyzed by using data from Taiwan's National Health Insurance Research Database from January 1996 to December 2012. The incidence and hazard ratios (HRs) for the development of new-onset anxiety/depression were examined between the two groups. Cox proportional hazard regression was applied to estimate the relative risks of anxiety/depressive disorders adjusted for potential confounding factors. To estimate the risks of anxiety/depression in different sub-groups, a stratified analysis was also used.
   Results
   HNC patients with preexisting hyperlipidemia had a higher risk for comorbidities such as hypertension, diabetes mellitus, and cardiovascular disease (P <0.001). The incidence rate of anxiety/depression in the HNC patients with preexisting hyperlipidemia was also significantly higher than that among patients without hyperlipidemia (10.78% vs 7.27%, respectively; P = 0.03). A Cox regression model revealed that preexisting hyperlipidemia was an independent risk factor for anxiety/depression (aHR, 1.96; 95% CI, 1.30-2.94). Statins use was protective against anxiety/depression among HNC patients with hyperlipidemia ( aHR, 0.85; 95% CI, 0.46-1.57), especially for individuals older than 65 years and for females.
   Conclusions
   Preexisting hyperlipidemia was associated with increased risk of new-onset anxiety/depression in the HNC patients. Statins use for HNC patients with hyperlipidemia could decrease the risk of anxiety/depression, especially for those older than 65 years and for female patients.
C1 [Huang, Chung-I] E Da Canc Hosp, Dept Radiat Oncol, Kaohsiung, Taiwan.
   [Lin, Li-Ching; Que, Jenny; Ting, Wei Chen; Yang, Ching-Chieh] Chi Mei Med Ctr, Dept Radiat Oncol, Tainan, Taiwan.
   [Tien, Hung-Cheng] Minist Hlth & Welf, Pingtung Hosp, Dept Psychiat, Pingtung, Taiwan.
   [Chen, Po-Chun] Pingtung Christian Hosp, Dept Radiat Oncol, Pingtung, Taiwan.
   [Wu, Hsin-Min] Natl Cheng Kung Univ, Dept Publ Hlth, Coll Med, Natl Cheng Kung Univ Hosp, Tainan, Taiwan.
   [Ho, Chung-Han; Wang, Jhi-Joung] Chi Mei Med Ctr, Dept Med Res, Tainan, Taiwan.
   [Ho, Chung-Han] Chia Nan Univ Pharm & Sci, Dept Pharm, Tainan, Taiwan.
   [Wang, Ren-Hong] Chi Mei Med Ctr, Dept Clin Pathol, Tainan, Taiwan.
   [Wang, Ren-Hong] Chung Hwa Univ Med Technol, Dept Med Lab Sci & Biotechnol, Tainan, Taiwan.
   [Yang, Ching-Chieh] Natl Sun Yat Sen Univ, Inst Biomed Sci, Kaohsiung, Taiwan.
   [Yang, Ching-Chieh] Chia Nan Univ Pharm & Sci, Dept Biotechnol, Tainan, Taiwan.
C3 E-Da Hospital; Chi Mei Hospital; National Cheng Kung University;
   National Cheng Kung University Hospital; Chi Mei Hospital; Chia Nan
   University of Pharmacy & Science; Chi Mei Hospital; Chung Hua
   University; National Sun Yat Sen University; Chia Nan University of
   Pharmacy & Science
RP Yang, CC (corresponding author), Chi Mei Med Ctr, Dept Radiat Oncol, Tainan, Taiwan.; Yang, CC (corresponding author), Natl Sun Yat Sen Univ, Inst Biomed Sci, Kaohsiung, Taiwan.; Yang, CC (corresponding author), Chia Nan Univ Pharm & Sci, Dept Biotechnol, Tainan, Taiwan.
EM cleanclear0905@gmail.com
RI Chen, Chin-Chuan/G-3094-2013; Yang, Ching-Chieh/JXN-6880-2024; Chen,
   PoChun/KIG-7338-2024
OI Ho, Chung-Han/0000-0001-5925-8477
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NR 33
TC 12
Z9 13
U1 0
U2 4
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAR 31
PY 2017
VL 12
IS 3
AR e0174574
DI 10.1371/journal.pone.0174574
PG 13
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Science & Technology - Other Topics
GA ER9VK
UT WOS:000399175000019
PM 28362860
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Maes, M
   Zhou, B
   Jirakran, K
   Vasupanrajit, A
   Boonchaya-Anant, P
   Tunvirachaisakul, C
   Tang, XO
   Li, J
   Almulla, AF
AF Maes, Michael
   Zhou, Bo
   Jirakran, Ketsupar
   Vasupanrajit, Asara
   Boonchaya-Anant, Patchaya
   Tunvirachaisakul, Chavit
   Tang, Xiaoou
   Li, Jing
   Almulla, Abbas F.
TI Towards a major methodological shift in depression research by assessing
   continuous scores of recurrence of illness, lifetime and current
   suicidal behaviors and phenome features
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Major depression; Biomarkers; Precision psychiatry; Neuro-immune;
   Inflammation; Oxidative stress
ID DENSITY-LIPOPROTEIN CHOLESTEROL; METABOLIC SYNDROME; RATING-SCALE;
   RESISTANCE; DISORDER; PLASMA
AB Background: The binary major depressive disorder (MDD) diagnosis is inadequate and should never be used in research. Aims: The study's objective is to explicate our novel precision nomothetic strategy for constructing depression models based on adverse childhood experiences (ACEs), lifetime and current phenome, and biomarker (atherogenicity indices) scores. Methods: This study assessed recurrence of illness (ROI: namely recurrence of depressive episodes and suicidal behaviors, SBs), lifetime and current SBs and the phenome of depression, neuroticism, dysthymia, anxiety disorders, and lipid biomarkers including apolipoprotein (Apo)A, ApoB, free cholesterol and cholesteryl esters, triglycerides, high density lipoprotein cholesterol in 67 normal controls and 66 MDD patients. We computed atherogenic and reverse cholesterol transport indices. Results: We were able to extract one factor from a) the lifetime phenome of depression comprising ROI, and traits such as neuroticism, dysthymia and anxiety disorders, and b) the phenome of the acute phase (based on depression, anxiety and quality of life scores). PLS analysis showed that 55.7 % of the variance in the lifetime + current phenome factor was explained by increased atherogenicity, neglect and sexual abuse, while atherogenicity partially mediated the effects of neglect. Cluster analysis generated a cluster of patients with major dysmood disorder, which was externally validated by increased atherogenicity and characterized by increased scores of all clinical features. Conclusions: The outcome of depression should not be represented as a binary variable (MDD or not), but rather as multiple dimensional scores based on biomarkers, ROI, subclinical depression traits, and lifetime and current phenome scores including SBs.
C1 [Maes, Michael; Zhou, Bo; Tang, Xiaoou; Li, Jing; Almulla, Abbas F.] Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Sichuan Prov Ctr Mental Hlth, Sch Med, Chengdu 610072, Peoples R China.
   [Maes, Michael; Zhou, Bo; Tang, Xiaoou; Li, Jing; Almulla, Abbas F.] Chinese Acad Med Sci, Key Lab Psychosomat Med, Chengdu 610072, Peoples R China.
   [Maes, Michael; Jirakran, Ketsupar; Vasupanrajit, Asara; Tunvirachaisakul, Chavit; Almulla, Abbas F.] Chulalongkorn Univ, Fac Med, Dept Psychiat, Bangkok, Thailand.
   [Maes, Michael; Jirakran, Ketsupar; Vasupanrajit, Asara; Tunvirachaisakul, Chavit; Almulla, Abbas F.] King Chulalongkorn Mem Hosp, Thai Red Cross Soc, Bangkok, Thailand.
   [Maes, Michael; Tunvirachaisakul, Chavit] Chulalongkorn Univ, Fac Med, Cognit Impairment & Dementia Res Unit, Bangkok, Thailand.
   [Maes, Michael] Med Univ Plovdiv, Dept Psychiat, Plovdiv, Bulgaria.
   [Maes, Michael] Med Univ Plovdiv, Res Inst, Plovdiv, Bulgaria.
   [Maes, Michael] Kyung Hee Univ, 26 Kyungheedae Ro, Seoul, South Korea.
   [Jirakran, Ketsupar] Chulalongkorn Univ, Fac Med, Ctr Excellence Maximizing Childrens Dev Potential, Dept Pediat, Bangkok, Thailand.
   [Boonchaya-Anant, Patchaya] Chulalongkorn Univ, Fac Med, Div Endocrinol & Metab, Div Endocrinol, Bangkok, Thailand.
   [Almulla, Abbas F.] Islamic Univ, Coll Med Technol, Med Lab Technol Dept, Najaf, Iraq.
C3 Sichuan Provincial People's Hospital; University of Electronic Science &
   Technology of China; Chinese Academy of Medical Sciences - Peking Union
   Medical College; Chulalongkorn University; Thai Red Cross Society;
   Chulalongkorn University; Chulalongkorn University; Medical University
   Plovdiv; Medical University Plovdiv; Kyung Hee University; Chulalongkorn
   University; Chulalongkorn University; Islamic University College
RP Li, J; Almulla, AF (corresponding author), Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Sichuan Prov Ctr Mental Hlth, Sch Med, Chengdu 610072, Peoples R China.; Li, J; Almulla, AF (corresponding author), Chinese Acad Med Sci, Key Lab Psychosomat Med, Chengdu 610072, Peoples R China.; Almulla, AF (corresponding author), Chulalongkorn Univ, Fac Med, Dept Psychiat, Bangkok, Thailand.; Almulla, AF (corresponding author), King Chulalongkorn Mem Hosp, Thai Red Cross Soc, Bangkok, Thailand.; Almulla, AF (corresponding author), Islamic Univ, Coll Med Technol, Med Lab Technol Dept, Najaf, Iraq.
EM cmhpublishing@uestc.edu.cn; abbass.chem.almulla1991@gmail.com
RI Almulla, Abbas F./GPW-6234-2022; Maes, Michael/B-8546-2011;
   Vasupanrajit, Asara/ABG-5437-2021
OI Maes, Michael/0000-0002-2012-871X
FU Ratchadapiseksompotch Fund, Faculty of Medicine, Chulalongkorn
   University [GA64/21]; Graduate School; King Bhumibhol Adulyadej's 72nd
   Birthday Anniversary Scholarship Chulalongkorn University; Sompoch
   Endowment Fund Faculty of Medicine, MDCU
FX This work was supported by the Ratchadapiseksompotch Fund, Faculty of
   Medicine, Chulalongkorn University (Grant number GA64/21) , a grant from
   the Graduate School and H.M. the King Bhumibhol Adulyadej's 72nd
   Birthday Anniversary Scholarship Chulalongkorn University, both to KJ,
   and the FF60 grant and Sompoch Endowment Fund from the Faculty of
   Medicine, MDCU to MM.
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NR 38
TC 10
Z9 10
U1 3
U2 7
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD APR 1
PY 2024
VL 350
BP 728
EP 740
DI 10.1016/j.jad.2024.01.150
EA JAN 2024
PG 13
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA JL8P5
UT WOS:001173418100001
PM 38246281
OA Green Submitted, hybrid
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Redon, J
   Lurbe, E
AF Redon, Josep
   Lurbe, Empar
TI The Kidney in Obesity
SO CURRENT HYPERTENSION REPORTS
LA English
DT Article
DE Obesity; Proteinuria; Chronic kidney disease; Obesity glomerulopathy;
   Perivascular fat
ID BODY-MASS INDEX; GLOMERULAR-FILTRATION-RATE; CORONARY-HEART-DISEASE;
   INDEPENDENT RISK-FACTOR; STAGE RENAL-DISEASE; METABOLIC SYNDROME;
   WEIGHT-LOSS; CARDIOVASCULAR RISK; ABDOMINAL OBESITY; FAT DISTRIBUTION
AB Body mass index has been found to be the second most important contributor to relative risk for developing end state renal disease (ESRD), after proteinuria. The impact of obesity on the kidney includes a wide spectrum, from characteristic pathologic lesions to increment in urinary albumin excretion (UAE) and proteinuria/or decrease in glomerular filtration rate (GFR). The cause of renal disease associated to obesity is not well understood, but two relevant elements emerge. The first is the presence of obesity-related glomerulopathy, and the second is the fat deposit in the kidney with impact on renal haemodynamics and intrarenal regulation. The mechanisms linking obesity and renal damage are complex and include haemodynamic changes, inflammation, oxidative stress, apoptosis, and finally renal scarring. The protection of kidney damage needs to combine weight reduction with the proper control of the cardiometabolic risk factors associated, hypertension, metabolic syndrome, diabetes and dyslipidaemia. The search for specific treatments merits future research.
C1 [Redon, Josep] Univ Valencia, Hosp Clin Valencia, Hypertens Clin, Valencia, Spain.
   [Redon, Josep] INCLIVA Res Inst, Valencia, Spain.
   [Redon, Josep; Lurbe, Empar] Inst Salud Carlos III, CIBERObn, Madrid, Spain.
   [Lurbe, Empar] Univ Valencia, Hosp Gen Valencia, Obes & Cardiovasc Risk Unit Children & Adolescent, Valencia, Spain.
C3 University of Valencia; CIBER - Centro de Investigacion Biomedica en
   Red; CIBEROBN; Instituto de Salud Carlos III; University of Valencia
RP Redon, J (corresponding author), INCLIVA, Inst Invest Biomed, Avda Blasco Ibanez 17, Valencia 46010, Spain.
EM Josep.redon@uv.es; Empar.lurbe@uv.es
RI Redon, Josep/L-5997-2019
OI Lurbe, Empar/0000-0002-3748-5529; Redon, Josep/0000-0001-8777-6773
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NR 95
TC 32
Z9 33
U1 0
U2 16
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1522-6417
EI 1534-3111
J9 CURR HYPERTENS REP
JI Curr. Hypertens. Rep.
PD JUN
PY 2015
VL 17
IS 6
AR 43
DI 10.1007/s11906-015-0555-z
PG 9
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA CI2WW
UT WOS:000354609700004
PM 25893477
DA 2025-06-11
ER

PT J
AU Mazidi, M
   Kengne, AP
   Sahebkar, A
   Banach, M
AF Mazidi, Mohsen
   Kengne, Andre Pascal
   Sahebkar, Amirhossein
   Banach, Maciej
TI Telomere Length Is Associated With Cardiometabolic Factors in US Adults
SO ANGIOLOGY
LA English
DT Article
DE telomere length; cardiometabolic factors; cardiovascular disease
ID C-REACTIVE PROTEIN; CARDIOVASCULAR RISK-FACTORS; BODY-MASS INDEX;
   METABOLIC SYNDROME; NATIONAL-HEALTH; SOCIOECONOMIC-STATUS; OBESITY;
   BLOOD; DYNAMICS; STRESS
AB Telomere length (TL) has been associated with age-related health outcomes. We investigated the relationship of TL with cardiometabolic risk profile in adult Americans. We used the National Health and Nutrition Examination Surveys for 1999 to 2002, accounting for complex sampling and survey design. Of the 8892 eligible participants, 47.8% (n = 4123) were men. Mean serum high-density lipoprotein cholesterol concentrations significantly increased across increasing TL quarters (P = .013), and mean fat mass, fat-free mass, hemoglobin A(1c) (HbA(1c)), and C-reactive protein significantly decreased across increasing TL quarters (all P < .001) in men. Only HbA(1c) levels significantly decreased across increasing TL quarters (P = .041) in women. Males in the upper quarter of TL had lower (38%) odds of prevalent metabolic syndrome compared with those in the lower quarter (P < .001). These results support the hypotheses that cardiometabolic factors are related to TL, especially in men.
C1 [Mazidi, Mohsen] Chinese Acad Sci, Inst Genet & Dev Biol, State Key Lab Mol Dev Biol, Beijing 100101, Peoples R China.
   [Mazidi, Mohsen] Univ Chinese Acad Sci, Inst Genet & Dev Biol, Int Coll, Beijing, Peoples R China.
   [Kengne, Andre Pascal] South African Med Res Council, Noncommunicable Dis Res Unit, Cape Town, South Africa.
   [Kengne, Andre Pascal] Univ Cape Town, Dept Med, Cape Town, South Africa.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Biotechnol Res Ctr, Mashhad, Iran.
   [Banach, Maciej] Med Univ Lodz, Dept Hypertens, Chair Nephrol & Hypertens, Lodz, Poland.
   [Banach, Maciej] PMMHRI, Lodz, Poland.
C3 Chinese Academy of Sciences; Institute of Genetics & Developmental
   Biology, CAS; Chinese Academy of Sciences; University of Chinese Academy
   of Sciences, CAS; Institute of Genetics & Developmental Biology, CAS;
   South African Medical Research Council; University of Cape Town; Mashhad
   University of Medical Sciences; Medical University Lodz
RP Mazidi, M (corresponding author), Chinese Acad Sci, Inst Genet & Dev Biol, State Key Lab Mol Dev Biol, Beijing 100101, Peoples R China.
EM moshen@genetics.ac.cn
RI Linn, Shai/N-3079-2019; Kengne, Andre/ABB-3696-2020; Sahebkar,
   Amirhossein/B-5124-2018; Banach, Maciej/A-1271-2009
OI Kengne, Andre Pascal/0000-0002-5183-131X; Banach,
   Maciej/0000-0001-6690-6874
FU World Academy of Sciences studentship of the Chinese Academy of Sciences
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: MM was
   supported by The World Academy of Sciences studentship of the Chinese
   Academy of Sciences during the preparation of this manuscript.
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NR 43
TC 37
Z9 39
U1 0
U2 16
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0003-3197
EI 1940-1574
J9 ANGIOLOGY
JI Angiology
PD FEB
PY 2018
VL 69
IS 2
BP 164
EP 169
DI 10.1177/0003319717712860
PG 6
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA FR5RM
UT WOS:000419123900011
PM 28583002
DA 2025-06-11
ER

PT J
AU Dearman, A
   Bao, YC
   Schalkwyk, L
   Kumari, M
AF Dearman, Anna
   Bao, Yanchun
   Schalkwyk, Leonard
   Kumari, Meena
TI Serum proteomic correlates of mental health symptoms in a representative
   UK population sample
SO BRAIN BEHAVIOR & IMMUNITY-HEALTH
LA English
DT Article
DE Proteomics; Proximity extension assay; Mental health; Psychological
   distress; Population health
ID MAJOR DEPRESSIVE DISORDER; PROTEIN-C INHIBITOR; METABOLIC SYNDROME;
   BLOOD-COAGULATION; NK CELLS; STRESS; SCHIZOPHRENIA; INFLAMMATION;
   ASSOCIATIONS; METAANALYSIS
AB Poor mental health constitutes a public health crisis due to its high prevalence, unmet need and its mechanistic heterogeneity. A comprehensive understanding of the biological correlates of poor mental health in the population could enhance epidemiological research and eventually help guide treatment strategies. The human bloodstream contains many proteins, several of which have been linked to diagnosed mental health conditions but not to population mental health symptoms, however recent technological advances have made this possible. Here we perform exploratory factor analyses of 184 proteins from two panels (cardiometabolic and neurologyrelated) measured using proximity extension assays from Understanding Society (the UK Household Longitudinal Study; UKHLS). Data reduction results in 28 factors that explain 55-59% of the variance per panel. We perform multiple linear regressions in up to 5304 participants using two mental health symptom-based outcomes: psychological distress assessed with the general health questionnaire (GHQ-12) and mental health functioning assessed with the 12-Item Short Form Survey, Mental Component Summary (SF12-MCS) using the proteomic factors as explanatory variables and adjusting for demographic covariates. We use backward selection to discard non-significant proteomic factors from the models. Ten factors are independently associated with population mental health symptoms, three of which are immune-related (immunometabolism, immune cell-mediated processes, acute phase processes), three brain-related (neurodevelopment, synaptic processes, neuroprotective processes), two proteolysis-related (proteolysis & the kynurenine pathway, haemostasis & proteolysis), growth factors & muscle, and oxidative stress & the cytoskeleton. Associations partially overlap across the two outcomes, and a sensitivity analysis excluding people taking antidepressants or other central nervous system medications suggestively implicates some of the factors in treatment-resistant poor mental health. Our findings replicate those of case-control studies and expand these to underlie mental health symptomatology in the adult population. More work is needed to understand the direction of causality in these associations.
C1 [Dearman, Anna; Kumari, Meena] Univ Essex, Inst Social & Econ Res, Wivenhoe Pk, Colchester CO4 3SQ, Essex, England.
   [Bao, Yanchun] Univ Essex, Sch Math Stat & Actuarial Sci SMSAS, Wivenhoe Pk, Colchester CO4 3SQ, Essex, England.
   [Schalkwyk, Leonard] Univ Essex, Sch Life Sci, Wivenhoe Pk, Colchester CO4 3SQ, Essex, England.
C3 University of Essex; University of Essex; University of Essex
RP Dearman, A (corresponding author), Univ Essex, Inst Social & Econ Res, Wivenhoe Pk, Colchester CO4 3SQ, Essex, England.
EM ad21432@essex.ac.uk
RI Dearman, Anna/MVU-8375-2025
FU Economic and Social Research Council (ESRC); ESRC [ES/S007253/1,
   ES/S012486/1, ES/N00812X/1, ES/T014083/1]; University of Essex, ESRC; 
   [MR/W004984/1];  [RES-596-28-0001]
FX Understanding Society is an initiative funded by the Economic and Social
   Research Council (ESRC) and various Government Departments, with
   scientific leadership by the Institute for Social and Economic Research,
   University of Essex, and survey delivery by NatCen Social Research and
   Kantar Public. The research data are distributed by the UK Data Service.
   A.D. was supported by the ESRC (ES/S007253/1 & ES/S012486/1) . Y.B. was
   partially supported by the ESRC (ES/N00812X/1) . L.S. is supported by
   MR/W004984/1. M.K. is supported by the University of Essex, ESRC
   (RES-596-28-0001) and ESRC (ES/S012486/1; ES/T014083/1) . The funders
   had no involvement in the analysis or preparation of the paper. We thank
   Professor Paul Clarke for his advice during this project. We would also
   like to thank the study participants who gave their time and blood
   samples to support Understanding Society's research.
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NR 115
TC 0
Z9 0
U1 2
U2 2
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2666-3546
J9 BRAIN BEHAV IMMUN-HL
JI Brain Behav. Immun.-Health
PD MAR
PY 2025
VL 44
AR 100947
DI 10.1016/j.bbih.2025.100947
EA JAN 2025
PG 12
WC Immunology; Neurosciences; Psychiatry
WE Emerging Sources Citation Index (ESCI)
SC Immunology; Neurosciences & Neurology; Psychiatry
GA W2A3W
UT WOS:001416663700001
PM 39911945
OA gold
DA 2025-06-11
ER

PT J
AU Amiri, P
   Deihim, T
   Hosseinpanah, F
   Barzin, M
   Hasheminia, M
   Montazeri, A
   Azizi, F
AF Amiri, P.
   Deihim, T.
   Hosseinpanah, F.
   Barzin, M.
   Hasheminia, M.
   Montazeri, A.
   Azizi, F.
TI Diagnostic values of different definitions of metabolic syndrome to
   detect poor health status in Iranian adults without diabetes
SO DIABETIC MEDICINE
LA English
DT Article
ID QUALITY-OF-LIFE; CARDIOVASCULAR RISK; PROVISIONAL REPORT; POPULATION;
   ASSOCIATION; DEPRESSION; GLUCOSE; PREVALENCE; DISEASE; IMPACT
AB Aims This study aimed to compare the diagnostic impact of four definitions of the metabolic syndrome for detection of poor health status in adults without diabetes living in Tehran. Methods A representative sample of 950 individuals (64% women), aged 20years, participants of the Tehran Lipid and Glucose Study in 2005-2007, were recruited for the study. Health status was assessed using the Iranian version of the 36-item Short Form Health Survey. We assessed the detectability of poor health status by definitions of the National Cholesterol Education Program Adult Treatment PanelIII, the International Diabetes Federation, the American Heart Association/National Heart, Lung, and the Blood Institute and the Joint Interim Statement. Results Compared with other definitions, the Joint Interim Statement identified more participants (46.9%) having the metabolic syndrome. Using the National Cholesterol Education Program Adult Treatment Panel III, the International Diabetes Federation and the Joint Interim Statement, the metabolic syndrome was significantly related to poor physical health status, even after adjustment for confounding variables, in women, but not in men. None of the four definitions of the metabolic syndrome was related to the mental health status in either gender. The receiver operating characteristic curves showed no significant difference in the discriminative power of the metabolic syndrome definitions in detecting poor health status in either gender. However, women showed a higher area under the curve for all definitions, in comparison with men. Conclusion There was no difference in the four different definitions of the metabolic syndrome in detecting poor health status among Iranian adults.
C1 [Amiri, P.; Deihim, T.] Shahid Beheshti Univ Med Sci, Res Inst Endocrine Sci, Res Ctr Social Determinants Endocrine Hlth, Tehran, Iran.
   [Amiri, P.; Deihim, T.; Hosseinpanah, F.; Barzin, M.; Hasheminia, M.] Shahid Beheshti Univ Med Sci, Res Inst Endocrine Sci, Obes Res Ctr, Tehran, Iran.
   [Montazeri, A.] ACECR, Iranian Inst Hlth Sci Res, Hlth Metr Res Ctr, Mental Hlth Res Grp, Tehran, Iran.
   [Azizi, F.] Shahid Beheshti Univ Med Sci, Res Inst Endocrine Sci, Endocrine Res Ctr, Tehran, Iran.
C3 Shahid Beheshti University Medical Sciences; Shahid Beheshti University
   Medical Sciences; Academic Center for Education, Culture & Research
   (ACECR); Shahid Beheshti University Medical Sciences
RP Hosseinpanah, F (corresponding author), Shahid Beheshti Univ Med Sci, Res Inst Endocrine Sci, Obes Res Ctr, Tehran, Iran.
EM fhospanah@endocrine.ac.ir
RI Montazeri, Ali/C-9276-2009; hosseinpanah, farhad/AAM-7277-2020;
   Hasheminia, Mitra/IXD-5283-2023; Amiri, Parisa/K-1575-2017; Azizi,
   Fereidoun/ABD-4136-2021
OI Amiri, Parisa/0000-0002-6693-1057; Azizi, Fereidoun/0000-0002-6470-2517;
   Montazeri, Ali/0000-0002-5198-9539
FU Research Institute for Endocrine Sciences, Shahid Beheshti University of
   Medical Sciences, Tehran, Iran
FX This study is funded by the Research Institute for Endocrine Sciences,
   Shahid Beheshti University of Medical Sciences, Tehran, Iran.
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NR 36
TC 7
Z9 7
U1 0
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0742-3071
EI 1464-5491
J9 DIABETIC MED
JI Diabetic Med.
PD JUL
PY 2014
VL 31
IS 7
BP 854
EP 861
DI 10.1111/dme.12443
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism
GA AJ4DL
UT WOS:000337621100015
PM 24654736
DA 2025-06-11
ER

PT J
AU Kirakosyan, A
   Seymour, EM
   Kondoleon, N
   Gutierrez, E
   Wolforth, J
   Bolling, S
AF Kirakosyan, Ara
   Seymour, E. Mitchell
   Kondoleon, Nicholas
   Gutierrez, Enrique
   Wolforth, Janet
   Bolling, Steven
TI The intake of red raspberry fruit is inversely related to cardiac risk
   factors associated with metabolic syndrome
SO JOURNAL OF FUNCTIONAL FOODS
LA English
DT Article
DE Red raspberry; Zucker Fatty rat; Type 2 diabetes mellitus;
   Cardiometabolic risk; Cardioprotection
ID KEY ENZYMES RELEVANT; POSTPRANDIAL GLYCEMIA; DIASTOLIC DYSFUNCTION;
   ALPHA-GLUCOSIDASE; OXIDATIVE STRESS; HEART-FAILURE; IN-VITRO; DIET;
   ANTHOCYANINS; CONSUMPTION
AB The effect of red raspberry fruit (RSP) was assessed in obesity-prone, Zucker Fatty rats as a model of cardiometabolic risk. RSP reduced fasting triglycerides and fasting glucose but did not appear to affect fasting insulin, low-density lipoprotein, or body weight gain. RSP did significantly reduce heart rate relative to time-matched CON rats. Noteworthy, RSP reduced left ventricular enlargement and wall thickening as measured by echocardiography, without impacting ejection fraction. Cardiac tissue was also evaluated for relative gene expression of key genes impacted in non-insulin-dependent diabetes mellitus (NIDDM). RSP upregulated the expression of myocardial adiponectin receptor 1 and apolipoprotein E, which may impact plasma cholesterol and triglyceride homeostasis. The lipoprotein lipase (Lpl) gene was down-regulated. On the contrary, RSP did not alter PPAR and NF-kB-related mRNA in heart tissue, but did alter nicotinamide phosphoribosyltransferase (Nampt) mRNA. RSP intake impacted cardiometabolic pathophysiology in this model, and molecular mechanisms deserve further study.
C1 [Kirakosyan, Ara; Seymour, E. Mitchell; Kondoleon, Nicholas; Gutierrez, Enrique; Wolforth, Janet; Bolling, Steven] Univ Michigan, Cardiac Surg, Ann Arbor, MI 48109 USA.
   [Gutierrez, Enrique] Univ San Pablo CEU, Fac Farm, Madrid, Spain.
C3 University of Michigan System; University of Michigan; San Pablo CEU
   University
RP Kirakosyan, A (corresponding author), Univ Michigan, NCRC, 2800 Plymouth Rd,NCRC Bldg 26-241S, Ann Arbor, MI 48109 USA.
EM akirakos@umich.edu
OI Kirakosyan, Ara/0000-0002-6269-9801; Kondoleon,
   Nicholas/0000-0002-2940-0070
FU National Processed Raspberry Council (USA)
FX This study was supported by an unrestricted grant from the National
   Processed Raspberry Council (USA).
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NR 29
TC 22
Z9 27
U1 0
U2 16
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1756-4646
EI 2214-9414
J9 J FUNCT FOODS
JI J. Funct. Food.
PD FEB
PY 2018
VL 41
BP 83
EP 89
DI 10.1016/j.jff.2017.12.033
PG 7
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA GA5GH
UT WOS:000428360700011
DA 2025-06-11
ER

PT J
AU Guijarro, SF
   Pomarol-Clotet, E
   Muñoz, MCR
   García, CM
   López, EE
   Guijarro, RF
   Pérez, LC
   Cuadra, MAR
AF Fernandez Guijarro, Sara
   Pomarol-Clotet, Edith
   Rubio Munoz, Ma Carmen
   Miguel Garcia, Carolina
   Egea Lopez, Elena
   Fernandez Guijarro, Rebeca
   Castan Perez, Lidia
   Rigol Cuadra, Ma Assumpta
TI Effectiveness of a community-based nurse-led lifestyle-modification
   intervention for people with serious mental illness and metabolic
   syndrome
SO INTERNATIONAL JOURNAL OF MENTAL HEALTH NURSING
LA English
DT Article
DE lifestyle; intervention; metabolic syndrome; nurse; serious mental
   illness
ID QUALITY-OF-LIFE; WEIGHT-LOSS; PHYSICAL HEALTH; MEDITERRANEAN DIET;
   ADULTS; PROGRAM; RISK; INDIVIDUALS; CONSUMERS; EXERCISE
AB The development of metabolic syndrome negatively affects the quality of life of people with serious mental illness. Experts agree on the need to evaluate the physical health of patients and intervene in modifiable risk factors, with emphasis on the promotion of healthy lifestyles. Interventions should include nutritional counselling and physical activity. This 24-week randomized trial evaluated the effects of a community-based nurse-led lifestyle-modification intervention in people with serious mental illness meeting metabolic syndrome criteria, and its impact on health-related quality of life and physical activity. Sixty-one participants from two community mental health centres were randomly assigned to the intervention or control group. The intervention consisted of weekly group sessions, with 20 min of theoretical content and 60 min of nurse-led physical activity. Postintervention results between groups showed no differences in weight, waist circumference, fasting glucose, and systolic blood pressure. Differences in body mass index, triglyceride concentrations, and diastolic blood pressure were found to be significant (P = 0.010, P = 0.038, and P = 0.017). Participants who performed the intervention reported an increase in physical activity, which did not occur in the control group (P = 0.035), and also reported better health status (P < 0.001). Our intervention showed positive effects reducing participants' cardiovascular and metabolic risks and improving their physical activity and quality of life. To our knowledge, this is the first clinical trial led and carried out by mental health nurses in community mental health centres which takes into account the effects of a lifestyle intervention on every metabolic syndrome criterion, health-related quality of life, and physical activity.
C1 [Fernandez Guijarro, Sara] Ramon & Cajal Hosp, Madrid, Spain.
   [Pomarol-Clotet, Edith] FIDMAG Hermanas Hosp Res Fdn, Barcelona, Spain.
   [Rubio Munoz, Ma Carmen] Bennito Menni Hlth Care Complex, St Boi De Llobregat, Spain.
   [Miguel Garcia, Carolina; Rigol Cuadra, Ma Assumpta] Univ Barcelona, Sch Nursing, Barcelona, Spain.
   [Egea Lopez, Elena] Murcia Hlth Serv, Murcia, Spain.
   [Castan Perez, Lidia] Univ Zaragoza, Sch Nursing Huesca, Zaragoza, Spain.
C3 Hospital Universitario Ramon y Cajal; University of Barcelona;
   University of Zaragoza
RP Guijarro, SF (corresponding author), Raman y Cajal Hosp, Ctr Salud Mental Barajas, Ave Gen 5, Madrid 28042, Spain.
EM s.fguijarro@hotmail.com
RI Fernández, Sara/AAH-1827-2019
OI fernandez guijarro, sara/0000-0001-7013-8636; Pomarol-Clotet,
   Edith/0000-0002-8159-8563
CR [Anonymous], 2014, PSYCH SCHIZ AD TREAT
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NR 46
TC 23
Z9 25
U1 0
U2 40
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1445-8330
EI 1447-0349
J9 INT J MENT HEALTH NU
JI Int. J. Ment. Health Nurs.
PD DEC
PY 2019
VL 28
IS 6
BP 1328
EP 1337
DI 10.1111/inm.12644
EA AUG 2019
PG 10
WC Nursing; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Psychiatry
GA JM5QQ
UT WOS:000481363500001
PM 31411375
DA 2025-06-11
ER

PT J
AU Steel, JL
   Cheng, H
   Pathak, R
   Wang, YS
   Miceli, J
   Hecht, CL
   Haggerty, D
   Peddada, S
   Geller, DA
   Marsh, W
   Antoni, M
   Jones, R
   Kamarck, T
   Tsung, A
AF Steel, Jennifer L.
   Cheng, Hannah
   Pathak, Ritambhara
   Wang, Yisi
   Miceli, Jessica
   Hecht, Carol Lynn
   Haggerty, Denise
   Peddada, Shyamal
   Geller, David A.
   Marsh, Wallis
   Antoni, Michael
   Jones, Reyna
   Kamarck, Thomas
   Tsung, Allan
TI Psychosocial and behavioral pathways of metabolic syndrome in cancer
   caregivers
SO PSYCHO-ONCOLOGY
LA English
DT Article
DE cancer; cardiovascular disease; caregivers; depression; oncology; social
   support; stress; quality of life
ID CORONARY-HEART-DISEASE; PERCEIVED STRESS; ALCOHOL-CONSUMPTION;
   PHYSICAL-ACTIVITY; RISK; METAANALYSIS; QUALITY; HEALTH; SCALE; HOSTILITY
AB Objective Cancer caregivers are at increased risk for cardiovascular disease (CVD) and mortality. The aims of this study were to examine psychosocial and behavioral predictors of metabolic syndrome, an intermediate endpoint of CVD. Methods Cancer caregivers were administered a battery of questionnaires assessing sociodemographic characteristics, depressive symptoms, perceived stress, caregiver quality of life, sleep, physical activity, alcohol and tobacco use, social support, relationship quality, and loneliness. Metabolic syndrome was defined using the American Heart Association guidelines and the National Cholesterol Education Program's Adult Treatment Panel (ATP) III, which includes the presence of at least three of the following abnormalities: blood pressure, glucose, abdominal girth, high-density lipoprotein (HDL), and triglycerides. Results Of the 104 caregivers, 77% were female, 94% were Caucasian, and the mean age was 59.5 (SD = 12.8). Of the 104 caregivers, 35.6% reported depressive symptoms in the clinical range of the Center for Epidemiologic Studies-Depression (CES-D) and 69.2% reported Perceived Stress Scale scores at least one standard deviation above the general population norms. A total of 16.3% of caregivers currently used tobacco, 28.8% consumed alcohol, and 26.7% were overweight (BMI = 25-29.9) and 48.5% were obese (BMI >= 30). Forty-nine percent of the caregivers met the criteria for metabolic syndrome. After age, gender, and race were adjusted, the following remained as significant predictors of metabolic syndrome: low levels of caregiver quality of life (Odds Ratio (OR) = 1.067; 95% CI, 1.019-1.117; P = .006), high levels of hostility (OR = 1.142; 95% CI, 1.030-1.267; P = .012), and current alcohol use (OR = 4.193; 95% CI, 1.174-14.978; P = .027). Conclusion Development of interventions to reduce the risk of metabolic syndrome in cancer caregivers is recommended.
C1 [Steel, Jennifer L.; Cheng, Hannah; Pathak, Ritambhara; Wang, Yisi; Miceli, Jessica; Hecht, Carol Lynn; Haggerty, Denise; Geller, David A.; Marsh, Wallis; Jones, Reyna; Tsung, Allan] Univ Pittsburgh, Dept Surg, 497 Scaife Hall, Pittsburgh, PA 15213 USA.
   [Kamarck, Thomas] Univ Pittsburgh, Dept Psychol, Pittsburgh, PA 15213 USA.
   [Steel, Jennifer L.] Univ Pittsburgh, Dept Psychiat, 3811 Ohara St, Pittsburgh, PA 15213 USA.
   [Peddada, Shyamal] Univ Pittsburgh, Sch Publ Hlth, Dept Biostat, Pittsburgh, PA 15213 USA.
   [Antoni, Michael] Univ Miami, Dept Psychol, Miami, FL USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE); University
   of Pittsburgh; Pennsylvania Commonwealth System of Higher Education
   (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of
   Higher Education (PCSHE); University of Pittsburgh; Pennsylvania
   Commonwealth System of Higher Education (PCSHE); University of
   Pittsburgh; University of Miami
RP Steel, JL (corresponding author), Univ Pittsburgh, Ctr Excellence Behav Med, 3459 Fifth Ave,Montefiore 7S, Pittsburgh, PA 15213 USA.; Steel, JL (corresponding author), Univ Pittsburgh, Surg Psychiat & Psychol, Sch Med, 3459 Fifth Ave,Montefiore 7S, Pittsburgh, PA 15213 USA.
EM steeljl@upmc.edu
RI Geller, David/AAV-8082-2020; Cheng, Hannah/JMR-2432-2023; Tsubata,
   Takeshi/AAI-7489-2021
OI Antoni, Michael/0000-0002-3971-0873; Wang, Yisi/0000-0003-1306-4444;
   Cheng, Hannah/0000-0001-8144-5340
FU NCI NIH HHS [R01CA196953, R01 CA196953] Funding Source: Medline
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NR 34
TC 16
Z9 17
U1 0
U2 11
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1057-9249
EI 1099-1611
J9 PSYCHO-ONCOLOGY
JI Psycho-Oncol.
PD AUG
PY 2019
VL 28
IS 8
BP 1735
EP 1742
DI 10.1002/pon.5147
PG 8
WC Oncology; Psychology; Psychology, Multidisciplinary; Social Sciences,
   Biomedical
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Oncology; Psychology; Biomedical Social Sciences
GA IM6KH
UT WOS:000478101300018
PM 31206896
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Pascoe, MC
   Thompson, DR
   Ski, CF
AF Pascoe, Michaela C.
   Thompson, David R.
   Ski, Chantal F.
TI Meditation and Endocrine Health and Wellbeing
SO TRENDS IN ENDOCRINOLOGY AND METABOLISM
LA English
DT Review
ID CENTRAL-NERVOUS-SYSTEM; TRANSCENDENTAL-MEDITATION; DEFAULT-MODE;
   MINDFULNESS PRACTICE; METABOLIC SYNDROME; STRESS REDUCTION;
   THYROID-HORMONES; NETWORK ACTIVITY; LONG-TERM; CORTISOL
AB Meditation is a popular practice for reducing stress and improving mental health and wellbeing. Its effects are mediated largely by the endocrine system, including the hypothalamic-pituitary-adrenal axis, the hypothalamic-pituitary-thyroid axis, and the renin-angiotensin-aldosterone system, and energy homeostasis. The limited evidence available indicates that changes associated with endocrine function following meditation correspond with improvements in mental health. However, this field of study is hampered by a lack of consensus as to definition and types of meditation and the mixed quality of reported studies. Moreover, the exact mechanisms by which meditation operates remain unclear and more robust studies are required to explore this by delineating the target populations, forms, dosages, and modes of delivery of meditation, comparison groups, and health experiences and outcomes used.
C1 [Pascoe, Michaela C.] Victoria Univ, Inst Sport Exercise & Act Living, Melbourne, Vic, Australia.
   [Thompson, David R.; Ski, Chantal F.] Univ Melbourne, Dept Psychiat, Melbourne, Vic, Australia.
   [Thompson, David R.; Ski, Chantal F.] Queens Univ Belfast, Sch Nursing & Midwifery, Belfast, Antrim, North Ireland.
C3 Victoria University; University of Melbourne; Queens University Belfast
RP Pascoe, MC (corresponding author), Victoria Univ, Inst Sport Exercise & Act Living, Melbourne, Vic, Australia.
EM Michaela.pascoe@vu.edu.au
RI Thompson, David/HJY-8387-2023; Ski, Chantal/AAJ-6595-2020; Thompson,
   David/E-2431-2018
OI Ski, Chantal/0000-0003-1324-2933; Pascoe, Michaela/0000-0002-3831-5660;
   Thompson, David/0000-0001-8518-6307
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NR 72
TC 17
Z9 20
U1 1
U2 39
PU CELL PRESS
PI CAMBRIDGE
PA 50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA
SN 1043-2760
EI 1879-3061
J9 TRENDS ENDOCRIN MET
JI Trends Endocrinol. Metab.
PD JUL
PY 2020
VL 31
IS 7
BP 469
EP 477
DI 10.1016/j.tem.2020.01.012
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism
GA LY2SP
UT WOS:000540373700001
PM 32037024
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Matta, J
   Hoertel, N
   Kesse-Guyot, E
   Plesz, M
   Wiernik, E
   Carette, C
   Czernichow, S
   Limosin, F
   Goldberg, M
   Zins, M
   Lemogne, C
AF Matta, Joane
   Hoertel, Nicolas
   Kesse-Guyot, Emmanuelle
   Plesz, Marie
   Wiernik, Emmanuel
   Carette, Claire
   Czernichow, Sebastien
   Limosin, Frederic
   Goldberg, Marcel
   Zins, Marie
   Lemogne, Cedric
TI Diet and physical activity in the association between depression and
   metabolic syndrome: Constances study
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Depression; Metabolic syndrome; Diet; Physical activity
ID SYMPTOMS; BEHAVIOR; HEALTH; ADULTS; RISK; PREVALENCE; PATTERNS;
   DISORDER; REWARD
AB Background: The association between depression and the metabolic syndrome remains poorly understood. Diet and physical activity may partly explain this association.
   Methods: Baseline data on 64,861 subjects from the French population-based Constances cohort was analyzed. Depressive symptoms were determined with the Center of Epidemiologic Studies Depression (CES-D) scale. A CES-D score 19 combined with self-reported limitations related to depressive symptoms was used to define depression. The metabolic syndrome was defined according to the International Diabetes Federation criteria. Dietary patterns were determined with a food frequency questionnaire and a principal component analysis. Physical activity was measured with 3 questions resulting in a composite 6-point scale. Associations between depression and the metabolic syndrome were estimated through logistic regression and path analysis.
   Results: The odds-ratios (95% confidence interval) for the association between depression and the metabolic syndrome, adjusting for age, sex, education and income, was 1.75 (1.57-1.96). The path analysis showed that 23% of this association was explained by diet and physical activity, 67% being attributed to physical activity.
   Limitations: The cross-sectional nature of the analyses warrants the results to be confirmed by longitudinal analyses.
   Conclusion: Diet and physical activity might partially explain the association between depressive symptoms and metabolic syndrome but other factors (e.g. inflammatory factors) are involved.
C1 [Matta, Joane; Hoertel, Nicolas; Czernichow, Sebastien; Limosin, Frederic; Lemogne, Cedric] Univ Paris 05, Sorbonne Paris Cite, Fac Med, 102 Rue Sante, F-74014 Paris, France.
   [Matta, Joane; Hoertel, Nicolas; Limosin, Frederic; Lemogne, Cedric] Hop Univ Paris Ouest, AP HP, Serv Psychiat Adulte & Sujet Age, Paris, France.
   [Matta, Joane; Hoertel, Nicolas; Limosin, Frederic; Lemogne, Cedric] Inserm, Ctr Psychiat & Neurosci, U894, Paris, France.
   [Kesse-Guyot, Emmanuelle] Univ Paris 05, U1153, Inra, Cnam,Inserm, Paris, France.
   [Kesse-Guyot, Emmanuelle] Univ Paris 07, U1153, Inra, Cnam,Inserm, Paris, France.
   [Kesse-Guyot, Emmanuelle] Univ Paris 13, U1153, Inra, Cnam,Inserm, Paris, France.
   [Plesz, Marie] CNRS, Ctr Maurice Halbwachs UMR8097, EHESS, ENS,INRA, Paris, France.
   [Wiernik, Emmanuel; Goldberg, Marcel; Zins, Marie] Inserm, Populat Based Epidemiol Cohorts Unit, UMS 011, Villejuif, France.
   [Carette, Claire; Czernichow, Sebastien] Hop Europeen Georges Pompidou, Serv Nutr, Paris, France.
C3 Universite Paris Cite; Assistance Publique Hopitaux Paris (APHP);
   Universite Paris Cite; Hopital Universitaire Europeen Georges-Pompidou -
   APHP; Universite Paris Cite; Institut National de la Sante et de la
   Recherche Medicale (Inserm); Institut National de la Sante et de la
   Recherche Medicale (Inserm); heSam Universite; Conservatoire National
   Arts & Metiers (CNAM); Universite Paris Cite; INRAE; Universite Paris
   Cite; INRAE; heSam Universite; Conservatoire National Arts & Metiers
   (CNAM); Institut National de la Sante et de la Recherche Medicale
   (Inserm); Universite Paris 13; Universite Paris Cite; INRAE; Institut
   National de la Sante et de la Recherche Medicale (Inserm); heSam
   Universite; Conservatoire National Arts & Metiers (CNAM); Universite
   PSL; Ecole Normale Superieure (ENS); Centre National de la Recherche
   Scientifique (CNRS); INRAE; Institut National de la Sante et de la
   Recherche Medicale (Inserm); Universite Paris Cite; Assistance Publique
   Hopitaux Paris (APHP); Universite Paris Cite; Hopital Universitaire
   Europeen Georges-Pompidou - APHP
RP Matta, J (corresponding author), Univ Paris 05, Sorbonne Paris Cite, Fac Med, 102 Rue Sante, F-74014 Paris, France.
EM joane.matta@inserm.fr
RI Zins, Marie/AAX-6551-2021; Kesse-Guyot, Emmanuelle/F-2692-2017; Lemogne,
   Cédric/Q-6091-2019; Hoertel, Nicolas/H-9457-2015; Goldberg,
   Marcel/I-7834-2012; Wiernik, Emmanuel/AAD-5519-2019
OI Plessz, Marie/0000-0001-7026-6224; Goldberg, Marcel/0000-0002-6161-5880;
   Carette, Claire/0000-0002-8175-0369; Wiernik,
   Emmanuel/0000-0001-8046-7919
FU ANR [ANR-11-INBS0002]; MSD; AstraZeneca; Lundbeck; IReSP
   [LEMOGNE-AAP16-PREV-13]
FX The Constances Cohort benefits from a grant from ANR (ANR-11-INBS0002).
   Constances is also partly funded by MSD, AstraZeneca and Lundbeck. The
   present analyses were funded by the IReSP(LEMOGNE-AAP16-PREV-13).
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   Zins M, 2015, EUR J EPIDEMIOL, V30, P1317, DOI 10.1007/s10654-015-0096-4
NR 46
TC 43
Z9 47
U1 0
U2 85
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD FEB 1
PY 2019
VL 244
BP 25
EP 32
DI 10.1016/j.jad.2018.09.072
PG 8
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA GZ2QZ
UT WOS:000449234400005
PM 30296663
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Daneshzad, E
   Keshavarz, SA
   Qorbani, M
   Larijani, B
   Azadbakht, L
AF Daneshzad, Elnaz
   Keshavarz, Seyed-Ali
   Qorbani, Mostafa
   Larijani, Bagher
   Azadbakht, Leila
TI Association between a low-carbohydrate diet and sleep status,
   depression, anxiety, and stress score
SO JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
LA English
DT Article
DE low-carbohydrate diet; dietary pattern; diabetes; depression; anxiety;
   sleep
ID METABOLIC SYNDROME; WEIGHT-LOSS; RISK; PATTERN; BEHAVIOR; PREVALENCE;
   ADHERENCE; SYMPTOMS; QUALITY
AB BACKGROUND Dietary intakes, especially carbohydrates, play an important role in blood glucose control in patients with diabetes. It is suggested that carbohydrate amounts may be effective in diabetes complications. This study aimed to reveal the association of low-carbohydrate diet (LCD) and sleep and mental status among patients with diabetes.
   METHODS This cross-sectional study was conducted among 265 women with type 2 diabetes. Anthropometric measures, as well as biochemical tests, were recorded. Dietary intakes were recorded using a validated food-frequency-questionnaire to calculate LCD score. To assess mental disorders and sleep quality, the Depression, Anxiety and Stress Scale and the Pittsburgh Sleep Quality Index were used respectively.
   RESULTS Patients in the highest LCD quartile were the ones with the lowest carbohydrate consumption. There was no significant association between cardiovascular risk factors and LCD score even after controlling confounder variables (P > 0.05). Subjects in the highest quartile of LCD score compared with those within the lowest quartile had a 69% lower risk of poor sleep after adjusting confounders. The odds of depressive symptoms were negatively related to the highest quartile of LCD score in the crude model and even after full-adjusted model (odds ratio: 0.42; 95% confidence interval: 0.17-1.01). Participants in the highest quartile of LCD score compared with those in the lowest quartile had a 73% lower risk of anxiety.
   CONCLUSION It seems that patients who consumed lower carbohydrate have better sleep status and are less involved with mental disorders. However, regarding the nature of the present study, well-designed cohort studies are suggested to be conducted in the future. (c) 2020 Society of Chemical Industry
C1 [Daneshzad, Elnaz; Azadbakht, Leila] Univ Tehran Med Sci, Dept Community Nutr, Sch Nutr Sci & Dietet, POB 1416643931, Tehran, Iran.
   [Keshavarz, Seyed-Ali] Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Clin Nutr, Tehran, Iran.
   [Qorbani, Mostafa] Alborz Univ Med Sci, Noncommunicable Dis Res Ctr, Karaj, Iran.
   [Qorbani, Mostafa] Univ Tehran Med Sci, Chron Dis Res Ctr, Endocrinol & Metab Populat Sci Inst, Tehran, Iran.
   [Larijani, Bagher] Tehran Univ Med Sci Tehran, Endocrinol & Metab Res Ctr, Endocrinol & Metab Clin Sci Inst, Tehran, Iran.
   [Azadbakht, Leila] Univ Tehran Med Sci, Diabet Res Ctr, Endocrinol & Metab Clin Sci Inst, Tehran, Iran.
C3 Tehran University of Medical Sciences; Tehran University of Medical
   Sciences; Alborz University of Medical Sciences; Tehran University of
   Medical Sciences; Tehran University of Medical Sciences; Tehran
   University of Medical Sciences
RP Azadbakht, L (corresponding author), Univ Tehran Med Sci, Dept Community Nutr, Sch Nutr Sci & Dietet, POB 1416643931, Tehran, Iran.
EM azadbakhtleila@gmail.com
RI larijani, Bagher/ABE-3315-2020; keshavarz, Seyed/AAD-3261-2019; Qorbani,
   Mostafa/M-8171-2017; Azadbakht, Leila/N-2801-2018; Daneshzad,
   Elnaz/O-3694-2018
OI Daneshzad, Elnaz/0000-0003-1400-8532; Larijani,
   Bagher/0000-0001-5386-7597
FU Tehran University of Medical Sciences [36923]
FX This study is supported by Tehran University of Medical Sciences (grant
   number: 36923).
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NR 42
TC 42
Z9 44
U1 0
U2 41
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-5142
EI 1097-0010
J9 J SCI FOOD AGR
JI J. Sci. Food Agric.
PD MAY
PY 2020
VL 100
IS 7
BP 2946
EP 2952
DI 10.1002/jsfa.10322
EA FEB 2020
PG 7
WC Agriculture, Multidisciplinary; Chemistry, Applied; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture; Chemistry; Food Science & Technology
GA LB9TC
UT WOS:000515197300001
PM 32031258
DA 2025-06-11
ER

PT J
AU Swaminathan, S
   Fonseca, VA
   Alam, MG
   Shah, SV
AF Swaminathan, Sundararaman
   Fonseca, Vivian A.
   Alam, Muhammad G.
   Shah, Sudhir V.
TI The role of iron in diabetes and its complications
SO DIABETES CARE
LA English
DT Review
ID CORONARY-HEART-DISEASE; TRANSFERRIN-BOUND IRON; C VIRUS-INFECTION; ACUTE
   MYOCARDIAL-INFARCTION; INSULIN-RESISTANCE SYNDROME; ELEVATED SERUM
   FERRITIN; IOWA WOMENS HEALTH; OXIDATIVE STRESS; THALASSEMIA MAJOR;
   CARDIOVASCULAR-DISEASE
C1 Univ Arkansas Med Sci, Div Nephrol, Little Rock, AR 72205 USA.
   Tulane Univ, Sch Med, Div Endocrinol, New Orleans, LA 70112 USA.
C3 University of Arkansas System; University of Arkansas Medical Sciences;
   Tulane University
RP Swaminathan, S (corresponding author), Univ Arkansas Med Sci, Div Nephrol, 4301 W Markham St,Slot 501, Little Rock, AR 72205 USA.
EM sswaminathan@uams.edu
RI Alam, Mohammad Gazi Shah/HLW-2112-2023
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NR 115
TC 306
Z9 336
U1 2
U2 20
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0149-5992
EI 1935-5548
J9 DIABETES CARE
JI Diabetes Care
PD JUL
PY 2007
VL 30
IS 7
BP 1926
EP 1933
DI 10.2337/dc06-2625
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 186GZ
UT WOS:000247768400050
PM 17429063
OA Bronze
DA 2025-06-11
ER

PT J
AU Hu, MX
   Penninx, BWJH
   de Geus, EJC
   Lamers, F
   Kuan, DCH
   Wright, AGC
   Marsland, AL
   Muldoon, MF
   Manuck, SB
   Gianaros, PJ
AF Hu, Mandy X.
   Penninx, Brenda W. J. H.
   de Geus, Eco J. C.
   Lamers, Femke
   Kuan, Dora C. -H.
   Wright, Aidan G. C.
   Marsland, Anna L.
   Muldoon, Matthew F.
   Manuck, Stephen B.
   Gianaros, Peter J.
TI Associations of immunometabolic risk factors with symptoms of depression
   and anxiety: The role of cardiac vagal activity
SO BRAIN BEHAVIOR AND IMMUNITY
LA English
DT Article
DE Depression; Anxiety; Inflammation; Metabolic syndrome; Autonomic nervous
   system; Cardiac vagal activity
ID HEART-RATE-VARIABILITY; AUTONOMIC NERVOUS-SYSTEM; C-REACTIVE PROTEIN;
   METABOLIC-SYNDROME; INFLAMMATORY MARKERS; CARDIOVASCULAR-DISEASE; MAJOR
   DEPRESSION; POPULATION; DISORDER; INVENTORY
AB Objectives: This study examined 1) the cross-sectional relationships between symptoms of depression/anxiety and immunometabolic risk factors, and 2) whether these relationships might be explained in part by cardiac vagal activity.
   Methods: Data were drawn from the Adult Health and Behavior registries (n=1785), comprised of community dwelling adults (52.8% women, aged 30-54). Depressive symptoms were measured with the Center for Epidemiological Studies Depression Scale (CES-D) and the Beck Depression Inventory-II (BDI-II), and anxious symptoms with the Trait Anxiety scale of the State-Trait Anxiety Inventory (STAI-T). Immunometabolic risk factors included fasting levels of triglycerides, high-density lipoproteins, glucose, and insulin, as well as blood pressure, waist circumference, body mass index, C-reactive protein, and interleukin-6. Measures of cardiac autonomic activity were high-and low-frequency indicators of heart rate variability (HRV), standard deviation of normal-to-normal R-R intervals, and the mean of absolute and successive differences in R-R intervals.
   Results: Higher BDI-II scores, in contrast to CES-D and STAI-T scores, were associated with increased immunometabolic risk and decreased HRV, especially HRV likely reflecting cardiac vagal activity. Decreased HRV was also associated with increased immunometabolic risk. Structural equation models indicated that BDI-II scores may relate to immunometabolic risk via cardiac vagal activity (indirect effect: beta=.012, p=.046) or to vagal activity via immunometabolic risk (indirect effect: beta=-.015, p=.021).
   Conclusions: Depressive symptoms, as measured by the BDI-II, but not anxious symptoms, were related to elevated levels of immunometabolic risk factors and low cardiac vagal activity. The latter may exhibit bidirectional influences on one another in a meditational framework. Future longitudinal, intervention, an nonhuman animal work is needed to elucidate the precise and mechanistic pathways linking depressive symptoms to immune, metabolic, and autonomic parameters of physiology that predispose to cardiovascular disease risk.
C1 [Hu, Mandy X.; Penninx, Brenda W. J. H.; Lamers, Femke] Vrije Univ Amsterdam Med Ctr, Amsterdam Publ Hlth Res Inst, Dept Psychiat, Amsterdam, Netherlands.
   [de Geus, Eco J. C.] Vrije Univ Amsterdam, Dept Biol Psychol, Amsterdam, Netherlands.
   [Kuan, Dora C. -H.; Wright, Aidan G. C.; Marsland, Anna L.; Manuck, Stephen B.; Gianaros, Peter J.] Univ Pittsburgh, Dept Psychol, Pittsburgh, PA 15260 USA.
   [Muldoon, Matthew F.] Univ Pittsburgh, Sch Med, Div Cardiol, Dept Med, Pittsburgh, PA 15260 USA.
C3 Vrije Universiteit Amsterdam; VU UNIVERSITY MEDICAL CENTER; Vrije
   Universiteit Amsterdam; Pennsylvania Commonwealth System of Higher
   Education (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth
   System of Higher Education (PCSHE); University of Pittsburgh
RP Hu, MX (corresponding author), Oldenaller 1, NL-1081 HJ Amsterdam, Netherlands.
EM m.hu@ggzingeest.nl
RI Lamers, Femke/G-5161-2012; Wright, Aidan/W-2821-2019; Stefanadis,
   Christodoulos/ABH-2232-2020; de Geus, Eco/M-9318-2015; Penninx, Brenda
   WJH/S-7627-2017
OI Stefanadis, Christodoulos/0000-0001-5974-6454; de Geus,
   Eco/0000-0001-6022-2666; Hu, Mandy Xian/0000-0002-4496-8772; Wright,
   Aidan/0000-0002-2369-0601; Lamers, Femke/0000-0003-4344-5766; Penninx,
   Brenda WJH/0000-0001-7779-9672
FU National Institutes of Health [PO1 HL040962, RO1 HL065137]
FX Preparation of this article was supported by the grants awarded to S.B.
   Manuck (PO1 HL040962 and RO1 HL065137) from the National Institutes of
   Health.
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NR 97
TC 13
Z9 14
U1 1
U2 11
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0889-1591
EI 1090-2139
J9 BRAIN BEHAV IMMUN
JI Brain Behav. Immun.
PD OCT
PY 2018
VL 73
BP 493
EP 503
DI 10.1016/j.bbi.2018.06.013
PG 11
WC Immunology; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Immunology; Neurosciences & Neurology; Psychiatry
GA GU6QO
UT WOS:000445440900048
PM 29920329
OA Green Accepted, Green Published
DA 2025-06-11
ER

PT J
AU Akinola, PS
   Tardif, I
   Leclerc, J
AF Akinola, Pelumi Samuel
   Tardif, Isabelle
   Leclerc, Jacinthe
TI Antipsychotic-Induced Metabolic Syndrome: A Review
SO METABOLIC SYNDROME AND RELATED DISORDERS
LA English
DT Review
DE antipsychotics; schizophrenia; metabolic syndrome; adverse events;
   adverse drug reaction
ID CLINICAL-PRACTICE GUIDELINES; SEVERE MENTAL-ILLNESS; WEIGHT-GAIN;
   2ND-GENERATION ANTIPSYCHOTICS; CARDIOVASCULAR-DISEASE;
   PHYSICAL-ACTIVITY; SCHIZOPHRENIA; MANAGEMENT; PREVENTION; DYSLIPIDEMIA
AB Schizophrenia, a serious psychiatric disorder, is among the top 10 global causes of disability and affects nearly 1% of the world population. Antipsychotics constitute the best treatment for patients with schizophrenia, however, this treatment class carries a high risk of metabolic syndrome, including lipid abnormalities. Indeed, the risk of metabolic syndrome would be increased in the population with schizophrenia compared to the general population. The objective is to summarize the prevalence, the mechanisms, and the potential treatments of antipsychotic-induced metabolic syndrome. This is a narrative review of the literature. We searched the electronic database Medline, accessed through PubMed, to find studies that investigated the prevalence and treatments of metabolic syndrome in the adult population using antipsychotics. The prevalence of metabolic syndrome in patients treated with antipsychotics ranges from 37% to 63%. Antipsychotic iatrogenic effects include weight gain/increased waist circumference, dyslipidemia, insulin resistance/type 2 diabetes, and hypertension. Clozapine and olanzapine are reported to precipitate the onset of metabolic syndrome features. In patients with metabolic syndrome, an antipsychotic with less metabolic side effects such as lurasidone, lumateperone, ziprasidone, and aripiprazole should be prioritized. Unlike medications, aerobic exercise and dietetic counseling were found to be efficient as the nonpharmacologic treatment of antipsychotic-induced metabolic syndrome. Few pharmacological treatments were proven effective against weight gain in this patient population. The risk of metabolic syndrome induced by antipsychotics should be early recognized and closely monitored. Primary and secondary prevention of metabolic syndrome or onset of its feature might help reduce the risk of death for patients using antipsychotics.
C1 [Akinola, Pelumi Samuel] Univ Manitoba, Coll Pharm, Rady Fac Hlth Sci, Winnipeg, MB, Canada.
   [Tardif, Isabelle] Univ Laval, Fac Med, Quebec City, PQ, Canada.
   [Leclerc, Jacinthe] Univ Laval, Fac Pharm, Quebec City, PQ, Canada.
   [Leclerc, Jacinthe] Univ Laval, Inst Univ Cardiol Pneumol Quebec, Ctr Rech, Quebec City, PQ, Canada.
   [Leclerc, Jacinthe] Univ Laval, Inst Univ Cardiol Pneumol Quebec, Ctr Rech, 2725 Chemin Sainte Foy,Local Y 3126, Quebec City, PQ G1V 4G5, Canada.
C3 University of Manitoba; Laval University; Laval University; Laval
   University; Laval University Hospital; Laval University; Laval
   University Hospital
RP Leclerc, J (corresponding author), Univ Laval, Inst Univ Cardiol Pneumol Quebec, Ctr Rech, 2725 Chemin Sainte Foy,Local Y 3126, Quebec City, PQ G1V 4G5, Canada.
EM jacinthe.leclerc@criucpq.ulaval.ca
RI Leclerc, Jacinthe/Q-7154-2019
OI Akinola, Pelumi Samuel/0000-0001-5326-7057
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NR 78
TC 13
Z9 14
U1 4
U2 29
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-4196
EI 1557-8518
J9 METAB SYNDR RELAT D
JI Metab. Syndr. Relat. Disord.
PD AUG 1
PY 2023
VL 21
IS 6
BP 294
EP 305
DI 10.1089/met.2023.0003
EA JUN 2023
PG 12
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA P4GN3
UT WOS:001014397800001
PM 37347965
DA 2025-06-11
ER

PT J
AU Renzaho, AMN
   Houng, B
   Oldroyd, J
   Nicholson, JM
   D'Esposito, F
   Oldenburg, B
AF Renzaho, Andre M. N.
   Houng, Brendan
   Oldroyd, John
   Nicholson, Jan M.
   D'Esposito, Fabrizio
   Oldenburg, Brian
TI Stressful life events and the onset of chronic diseases among Australian
   adults: findings from a longitudinal survey
SO EUROPEAN JOURNAL OF PUBLIC HEALTH
LA English
DT Article
ID AFRICAN-AMERICAN WOMEN; SOCIAL SUPPORT; BREAST-CANCER;
   PSYCHOLOGICAL-FACTORS; METABOLIC SYNDROME; HEART-DISEASE; JOB STRAIN;
   RISK; HEALTH; ASTHMA
AB Objectives: This article examines the link between stressful life events and illness by considering both onset and reoccurrence of chronic illnesses. Using longitudinal data, we estimate the extent to which life events increase the likelihood of depression or anxiety, type 2 diabetes, cancer, coronary heart disease, circulatory disease, asthma and emphysema among Australian adults aged epsilon 21 years. Methods: Longitudinal data were obtained from the nationally representative Household, Income and Labour Dynamics in Australia panel survey collected at waves 3 (2003), 7 (2007) and 9 (2009). Participants (N = 9222) answered life events questions relating to the preceding 12 months and chronic illnesses lasting (or expected to last for) 6 months. Weighted pooled and random effects logistic regressions were performed, controlling for confounders and previous illness, and also performed on subsamples delineated by reported illnesses in wave 3. Results: Work-related stress [odds ratio (OR) = 1.54, P < 0.001] was positively associated with the onset of depression or anxiety. Personal stress increased the likelihood of the onset of depression or anxiety (OR = 1.70, P < 0.001), type 2 diabetes (OR = 1.47, P < 0.05) and circulatory diseases (OR = 1.72, P < 0.05), while family-related stress increased the likelihood of the onset of heart (OR = 1.32, P < 0.01) and circulatory diseases (OR = 1.32, P < 0.05). Conclusions: Independent of personal characteristics and key health measures (body mass index, hypertension and disability), these findings suggest that work-related, personal and family-related stressful life events contribute to the development and/or course of chronic diseases.
C1 [Renzaho, Andre M. N.; Oldroyd, John; Oldenburg, Brian] Monash Univ, Sch Publ Hlth & Prevent Med, Int Publ Hlth Unit, Melbourne, Vic 3004, Australia.
   [Houng, Brendan] Univ Melbourne, Melbourne Inst Appl Econ & Social Res, Melbourne, Vic 3010, Australia.
   [Nicholson, Jan M.; D'Esposito, Fabrizio] Parenting Res Ctr, East Melbourne, Vic, Australia.
C3 Monash University; University of Melbourne
RP Renzaho, AMN (corresponding author), Monash Univ, Sch Publ Hlth & Prevent Med, Int Publ Hlth Unit, Level 3,Burnet Bldg,89 Commercial Rd, Melbourne, Vic 3004, Australia.
EM andre.renzaho@monash.edu
RI Renzaho, Andre/AAH-7679-2021; Houng, Brendan/P-3147-2015
OI RENZAHO, ANDRE/0000-0002-6844-0833; Oldenburg,
   Brian/0000-0002-7712-5413; Houng, Brendan/0000-0002-0858-7876; Oldroyd,
   John/0000-0002-2269-6294; Nicholson, Jan/0000-0002-0305-0017
FU ARC; Victorian Government Department of Education and Early Child
   Development; Australian Government Department of Families, Housing,
   Community Services and Indigenous Affairs (FaHCSIA)
FX A/Prof. Andre Renzaho is supported by an ARC Future Fellowship. Prof
   Nicholson and Dr D'Esposito were supported by funding from the Victorian
   Government Department of Education and Early Child Development. This
   article uses unit record data from the HILDA survey. The HILDA project
   was initiated and is funded by the Australian Government Department of
   Families, Housing, Community Services and Indigenous Affairs (FaHCSIA)
   and is managed by the Melbourne Institute of Applied Economic and Social
   Research (Melbourne Institute). The findings and views reported in this
   article, however, are those of the author and should not be attributed
   to either FaHCSIA or the Melbourne Institute.
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NR 40
TC 64
Z9 68
U1 0
U2 30
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1101-1262
EI 1464-360X
J9 EUR J PUBLIC HEALTH
JI Eur. J. Public Health
PD FEB
PY 2014
VL 24
IS 1
BP 57
EP 62
DI 10.1093/eurpub/ckt007
PG 6
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA AA1EC
UT WOS:000330838200014
PM 23397581
OA Bronze
DA 2025-06-11
ER

PT J
AU Tziallas, D
   Kastanioti, C
   Kostapanos, MS
   Skapinakis, P
   Elisaf, MS
   Mavreas, V
AF Tziallas, Dimitrios
   Kastanioti, Catherine
   Kostapanos, Michael S.
   Skapinakis, Petros
   Elisaf, Moses S.
   Mavreas, Venetsanos
TI The impact of the metabolic syndrome on health-related quality of life:
   a cross-sectional study in Greece
SO EUROPEAN JOURNAL OF CARDIOVASCULAR NURSING
LA English
DT Article
DE Health-related quality of life; metabolic syndrome; cardiovascular
   disease; depression
ID DEPRESSIVE SYMPTOMS; HOSPITAL ANXIETY; RISK; OBESITY; PREVALENCE;
   WEIGHT; POPULATION; COMPONENTS; SF-36
AB Background: Metabolic syndrome [MetS] is a chronic, progressive and multi-complex health problem that can trigger physical, emotional and psychosocial problems. The aim of this study is to investigate the association between MetS and health-related quality of life (HRQoL) as well as depressive and anxiety disorders.
   Methods: New consecutive patients who attended an outpatient lipid clinic for evaluation for MetS were eligible for inclusion in the study. The MetS was defined according to the new definition of International Diabetes Federation (IDF). The Medical Outcomes Study, Short Form-36 (SF-36) was used to assess HRQoL. Anxiety and depressive symptoms were assessed by a validated Greek version of the Hospital Anxiety and Depression Scale (HADS).
   Results: Three hundred and fifty-nine subjects were involved of whom 206 [57.4%] met the diagnostic criteria for the MetS (cases) and 153 [42.6%] were free of MetS criteria (comparator group). MetS was associated with lower scores of all subscales of the SF-36 except of bodily pain. The physical component summary score of SF-36 was independently associated with gender (beta = 2.41, P = .01), married or living together (beta = 5.18, P = .001) and satisfactory household income (beta = 5.77, P < .0001). The mental component summary score of SF-36 was independently associated with gender (beta = 3.20, P = .003) and satisfactory household income (beta = 3.94, P = .02). A predominance of anxiety and depressive symptoms was observed among subjects with MetS.
   Conclusions: Our study demonstrated that subjects with MetS have significantly more impaired HRQoL than those without MetS. These findings suggest that HRQoL should be considered in the management of subjects with MetS.
C1 [Tziallas, Dimitrios; Kostapanos, Michael S.; Elisaf, Moses S.] Univ Ioannina, Dept Internal Med, GR-45110 Ioannina, Greece.
   [Kastanioti, Catherine] Technol Inst Kalamata, Dept Hlth Care Management, Kalamata, Greece.
   [Skapinakis, Petros; Mavreas, Venetsanos] Univ Ioannina, Sch Med, Dept Psychiat, GR-45110 Ioannina, Greece.
C3 University of Ioannina; Technical Educational Institute Kalamata;
   University of Ioannina
RP Tziallas, D (corresponding author), Univ Hosp Ioannina, Dept Internal Med, Ioannina 45500, Greece.
EM dtziallas@gmail.com
RI Kostapanos, Michalis/AAB-2411-2020; Kastanioti, Catherine/AAM-9130-2021;
   Skapinakis, Petros/B-8718-2011
OI Skapinakis, Petros/0000-0003-1450-8051; ELISAF,
   MOSES/0000-0003-0505-078X; Kostapanos, Michalis/0000-0002-7513-5319
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NR 40
TC 38
Z9 41
U1 0
U2 9
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1474-5151
EI 1873-1953
J9 EUR J CARDIOVASC NUR
JI Eur. J. Cardiovasc. Nurs.
PD SEP
PY 2012
VL 11
IS 3
SI SI
BP 297
EP 303
DI 10.1016/j.ejcnurse.2011.02.004
PG 7
WC Cardiac & Cardiovascular Systems; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Cardiovascular System & Cardiology; Nursing
GA 046YQ
UT WOS:000311802200007
PM 21398183
OA Bronze
DA 2025-06-11
ER

PT J
AU Pischke, CR
   Frenda, S
   Ornish, D
   Weidner, G
AF Pischke, Claudia Ruth
   Frenda, Steven
   Ornish, Dean
   Weidner, Gerdi
TI Lifestyle changes are related to reductions in depression in persons
   with elevated coronary risk factors
SO PSYCHOLOGY & HEALTH
LA English
DT Article
DE elevated coronary risk factors; depressive symptoms; lifestyle changes
ID TYPE-2 DIABETES-MELLITUS; METABOLIC SYNDROME; HEART-DISEASE;
   PHYSICAL-ACTIVITY; GLYCEMIC CONTROL; PREVENTION; SYMPTOMS; EXERCISE;
   DIET; PREVALENCE
AB This observational study investigates whether persons with elevated coronary risk factors (CRFs 3 and/or diabetes) and depression [i.e., epsilon 16 on the Center for Epidemiological Scale - Depression (CES-D)] can make changes in health behaviours over 3 months and improve depressive symptoms and other CRFs. Analyses were based on data from 310 men and 687 women enrolled in the high-risk arm of the Multisite Cardiac Lifestyle Intervention Program, targeting diet (10% fat), exercise (3 h per week) and stress management (7 h per week). As expected, at study entry, depressed persons had a more adverse medical status, consumed more dietary fat and practiced less stress management than non-depressed persons. To examine 3-month changes, participants were grouped into (1) depressed persons who became non-depressed (CES-D 16, n = 248; 73%), (2) persons who remained or became depressed (CES-D 16, n = 76) and (3) non-depressed persons who remained non-depressed (n = 597). All persons, regardless of group, met program goals. The greatest improvements (i.e., diet, exercise, perceived stress, hostility and mental health) were observed in Group 1 relative to Groups 2 and 3, which did not differ from each other. Comprehensive lifestyle changes appear to be feasible and beneficial for initially depressed persons with elevated CRFs.
C1 [Weidner, Gerdi] San Francisco State Univ, Tiburon, CA 94920 USA.
   [Weidner, Gerdi] Johannes Gutenberg Univ Mainz, D-55122 Mainz, Germany.
   [Pischke, Claudia Ruth] Harvard Univ, Sch Publ Hlth, Dana Farber Canc Inst, Boston, MA 02130 USA.
   [Frenda, Steven; Ornish, Dean] Res Inst Prevent Med, Sausalito, CA 94965 USA.
C3 California State University System; San Francisco State University;
   Johannes Gutenberg University of Mainz; Harvard University; Harvard
   University Medical Affiliates; Dana-Farber Cancer Institute; Harvard
   T.H. Chan School of Public Health
RP Weidner, G (corresponding author), San Francisco State Univ, 3150 Paradise Dr, Tiburon, CA 94920 USA.
EM gweidner@sfsu.edu
OI Pischke, Claudia/0000-0002-2256-8903
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NR 67
TC 15
Z9 19
U1 0
U2 20
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0887-0446
EI 1476-8321
J9 PSYCHOL HEALTH
JI Psychol. Health
PY 2010
VL 25
IS 9
BP 1077
EP 1100
AR PII 917229765
DI 10.1080/08870440903002986
PG 24
WC Public, Environmental & Occupational Health; Psychology,
   Multidisciplinary
WE Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; Psychology
GA 676BI
UT WOS:000283884700004
PM 20204946
DA 2025-06-11
ER

PT J
AU Heiskanen, TH
   Niskanen, LK
   Hintikka, JJ
   Koivumaa-Honkanen, HT
   Honkalampi, KM
   Haatainen, KM
   Viinamäki, HT
AF Heiskanen, Tuula H.
   Niskanen, Leo K.
   Hintikka, Jukka J.
   Koivumaa-Honkanen, Heli T.
   Honkalampi, Kirsi M.
   Haatainen, Kaisa M.
   Viinamaki, Heimo T.
TI Metabolic syndrome and depression:: A cross-sectional analysis
SO JOURNAL OF CLINICAL PSYCHIATRY
LA English
DT Article
ID TORONTO-ALEXITHYMIA-SCALE; INSULIN-RESISTANCE; PSYCHOMETRIC PROPERTIES;
   RISK; MORTALITY; PREVALENCE; SYMPTOMS; DISEASE; HEART; SCHIZOPHRENIA
AB Objective: To examine the prevalence of the metabolic syndrome in depressive outpatients and to identify its correlates in depression.
   Method: This cross-sectional analysis was performed on 121 depressive outpatients from January 2002 through January 2004 who were diagnosed at baseline with the Structured Clinical Interview for DSM-III-R. The metabolic syndrome was diagnosed at 6-year follow-up according to the modified criteria of the National Cholesterol Education Program. The severity of depressive symptoms was assessed at follow-up with the Beck Depression Inventory and the Hamilton Rating Scale for Depression, and general psychopathology was assessed with the Symptom Checklist-90.
   Results: At 6-year follow-up, the prevalence of metabolic syndrome in the study group of depressive outpatients was 36% (N = 44). The syndrome was associated with a current diagnosis of major depression and overeating, but not with age or sex.
   Conclusion: The metabolic syndrome is highly prevalent among patients with a history of depression, especially those with current major depression. This may have implications for treatment. Furthermore, attention should be focused on the physical health of those suffering from depression.
C1 Kuopio Univ Hosp, Dept Psychiat, FIN-70211 Kuopio, Finland.
   Kuopio Univ Hosp, Dept Med, FIN-70211 Kuopio, Finland.
   Paijat Hame Cent Hosp, Dept Psychiat, Lahti, Finland.
   Univ Tampere, Dept Psychiat, FIN-33101 Tampere, Finland.
C3 Kuopio University Hospital; Kuopio University Hospital; Paijat Hame
   Central Hospital; Tampere University
RP Heiskanen, TH (corresponding author), Kuopio Univ Hosp, Dept Psychiat, POB 1777, FIN-70211 Kuopio, Finland.
EM tuula.heiskanen@kuh.fi
RI Koivumaa-Honkanen, Heli/L-1274-2015
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NR 47
TC 121
Z9 129
U1 1
U2 11
PU PHYSICIANS POSTGRADUATE PRESS
PI MEMPHIS
PA P O BOX 752870, MEMPHIS, TN 38175-2870 USA
SN 0160-6689
EI 1555-2101
J9 J CLIN PSYCHIAT
JI J. Clin. Psychiatry
PD SEP
PY 2006
VL 67
IS 9
BP 1422
EP 1427
DI 10.4088/JCP.v67n0913
PG 6
WC Psychology, Clinical; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA 095WN
UT WOS:000241339100013
PM 17017829
DA 2025-06-11
ER

PT J
AU Roberts, CK
   Hevener, AL
   Barnard, RJ
AF Roberts, Christian K.
   Hevener, Andrea L.
   Barnard, R. James
TI Metabolic Syndrome and Insulin Resistance: Underlying Causes and
   Modification by Exercise Training
SO COMPREHENSIVE PHYSIOLOGY
LA English
DT Article
ID C-REACTIVE PROTEIN; HUMAN SKELETAL-MUSCLE; NECROSIS-FACTOR-ALPHA; TIME
   PHYSICAL-ACTIVITY; ENDOPLASMIC-RETICULUM STRESS; SUBCUTANEOUS
   ADIPOSE-TISSUE; TYPE-2 DIABETES-MELLITUS; TYROSINE-PHOSPHATASE 1B;
   ACID-BINDING PROTEIN; ACYLATION-STIMULATING PROTEIN
AB Metabolic syndrome (MS) is a collection of cardiometabolic risk factors that includes obesity, insulin resistance, hypertension, and dyslipidemia. Although there has been significant debate regarding the criteria and concept of the syndrome, this clustering of risk factors is unequivocally linked to an increased risk of developing type 2 diabetes and cardiovascular disease. Regardless of the true definition, based on current population estimates, nearly 100 million have MS. It is often characterized by insulin resistance, which some have suggested is a major underpinning link between physical inactivity and MS. The purpose of this review is to: (i) provide an overview of the history, causes and clinical aspects of MS, (ii) review the molecular mechanisms of insulin action and the causes of insulin resistance, and (iii) discuss the epidemiological and intervention data on the effects of exercise on MS and insulin sensitivity. (C) 2013 American Physiological Society. Compr Physiol 3:1-58, 2013.
C1 [Roberts, Christian K.] Univ Calif Los Angeles, Sch Nursing, Translat Sci Sect, Exercise & Metab Dis Res Lab, Los Angeles, CA 90024 USA.
   [Hevener, Andrea L.] Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Div Endocrinol, Los Angeles, CA 90095 USA.
   [Barnard, R. James] Univ Calif Los Angeles, Dept Integrat Biol & Physiol, Los Angeles, CA USA.
C3 University of California System; University of California Los Angeles;
   University of California System; University of California Los Angeles;
   University of California Los Angeles Medical Center; David Geffen School
   of Medicine at UCLA; University of California System; University of
   California Los Angeles
RP Roberts, CK (corresponding author), Univ Calif Los Angeles, Sch Nursing, Translat Sci Sect, Exercise & Metab Dis Res Lab, Los Angeles, CA 90024 USA.
EM croberts@ucla.edu
RI Stefanadis, Christodoulos/ABH-2232-2020
OI Stefanadis, Christodoulos/0000-0001-5974-6454
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NR 732
TC 561
Z9 635
U1 4
U2 128
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 2040-4603
J9 COMPR PHYSIOL
JI Compr. Physiol.
PD JAN
PY 2013
VL 3
IS 1
BP 1
EP 58
DI 10.1002/cphy.c110062
PG 58
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA 086AH
UT WOS:000314654900001
PM 23720280
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Perez-Cornago, A
   Ramírez, MJ
   Zulet, MA
   Martinez, JA
AF Perez-Cornago, Aurora
   Ramirez, Maria J.
   Zulet, M. Angeles
   Martinez, J. Alfredo
TI Effect of dietary restriction on peripheral monoamines and anxiety
   symptoms in obese subjects with metabolic syndrome
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE Peripheral monoamines; Anxiety symptoms; Serotonin; Dopamine; Metabolic
   syndrome; Weight loss; Diet
ID WEIGHT-LOSS; BLOOD SEROTONIN; DOPAMINE; DEPRESSION; SYSTEM; ASSOCIATION;
   OVERWEIGHT; FAT; RECEPTORS; PROTEINS
AB Reduced circulating monoamines may have a role in the development of the metabolic syndrome (MetS), which is becoming a major health problem worldwide. Moreover, an association between anxiety disorder and MetS has been reported; however, it is not clear whether weight loss can diminish anxiety. This investigation is aimed to examine the effects of a weight loss intervention on peripheral monoamines levels and anxiety symptoms in subjects with metabolic syndrome (MetS). The study population encompassed subjects with MetS (age: 50 10 y.o. and BMI: 35.8 +/- 4.3 kg/m(2)) selected from the RESMENA study after they had completed the 6-month weight loss intervention (-30% energy). Anthropometric measurements, dietary records, anxiety symptoms, and blood monoamines levels were analysed before and after the intervention. Dopamine (DA) (+18.2%; 95% confidence interval (Cl): -51.2 to -0.5) and serotonin (5-HT) (+16.1%; 95% Cl: -26.3 to -2.2) blood levels were significantly increased after the intervention. Higher DA blood concentrations at the end of the study were inversely related with the carbohydrate intake during the study (B = -3.3; 95% Cl: -8.4 to 0.4) and basal DA levels predicted a greater decrease in body weight and anthropometric parameters. Subjects with higher 5-HT concentrations after the weight loss intervention also showed a lower energy intake during the intervention (B = 0.04; 95% Cl: 0.07 to 0.01). Additionally, anxiety symptoms decreased after the weight toss treatment (-28.3%; 95% Cl: 6.2-20.4), which was parallel to a greater decrease in body weight and anthropometric markers, being related to lower 5-HT basal levels. Dietary restriction in patients with MetS may help in reducing anxiety symptoms, and also in increasing 5-HTand DA blood levels. These results provide further insights regarding emotional and neurological factors behind weight loss. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Perez-Cornago, Aurora; Zulet, M. Angeles; Martinez, J. Alfredo] Univ Navarra, Dept Nutr Food Sci & Physiol, Ctr Nutr Res, Pamplona 31008, Spain.
   [Ramirez, Maria J.] Univ Navarra, Dept Pharmacol & Toxicol, Pamplona 31008, Spain.
   [Zulet, M. Angeles; Martinez, J. Alfredo] Carlos III Hlth Res Inst, CIBERobn, Madrid, Spain.
C3 University of Navarra; University of Navarra; CIBER - Centro de
   Investigacion Biomedica en Red; CIBEROBN
RP Martinez, JA (corresponding author), Univ Navarra, Dept Nutr Food Sci & Physiol, C Irunlarrea 1, Pamplona 31008, Spain.
EM jalfmtz@unav.es
RI Perez-Cornago, Aurora/C-1097-2016; Martinez Hernandez, J
   Alfredo/K-8709-2014; Zulet, M. Angeles/H-1317-2017; Ramirez, Maria
   Javier/H-4383-2017
OI Perez-Cornago, Aurora/0000-0002-5652-356X; Martinez Hernandez, J
   Alfredo/0000-0001-5218-6941; Zulet, M. Angeles/0000-0002-3926-0892;
   Ramirez, Maria Javier/0000-0002-3488-9579
FU Health Department of the Government of Navarra [48/2009]; Linea Especial
   about Nutrition, Obesity and Health (University of Navarra) [LE/97];
   Asociacion de Amigos Universidad de Navarra
FX This study was supported by the Health Department of the Government of
   Navarra (48/2009) and the Linea Especial about Nutrition, Obesity and
   Health (University of Navarra LE/97). The pre-doctoral research grant to
   Aurora Perez-Cornago from the Asociacion de Amigos Universidad de
   Navarra is gratefully acknowledged. The funding sources had no role in
   study design; in the collection, analysis and interpretation of data; in
   the writing of the report; and in the decision to submit the paper for
   publication.
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NR 47
TC 15
Z9 16
U1 0
U2 13
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD SEP
PY 2014
VL 47
BP 98
EP 106
DI 10.1016/j.psyneuen.2014.05.003
PG 9
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA AM2PY
UT WOS:000339694500011
PM 25001959
DA 2025-06-11
ER

PT J
AU Saloner, R
   Marquine, MJ
   Sundermann, EE
   Hong, SZ
   McCutchan, JA
   Ellis, RJ
   Heaton, RK
   Grant, I
   Cherner, M
AF Saloner, Rowan
   Marquine, Maria J.
   Sundermann, Erin E.
   Hong, Suzi
   McCutchan, John Allen
   Ellis, Ronald J.
   Heaton, Robert K.
   Grant, Igor
   Cherner, Mariana
TI COMT Val1 58Met Polymorphism, Cardiometabolic Risk, and Nadir CD4
   Synergistically Increase Risk of Neurocognitive Impairment in Men Living
   With HIV
SO JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
LA English
DT Article; Proceedings Paper
CT Annual Conference of the International-Neuropsychological-Society (INS)
CY FEB 21, 2019
CL New York, NY
SP Int Neuropsychol Soc
DE neuroAIDS; catechol-o-methyltransferase; HIV-associated neurocognitive
   disorders; metabolic syndrome; dopamine; immunosuppression
ID CATECHOL-O-METHYLTRANSFERASE; HUMAN-IMMUNODEFICIENCY-VIRUS; METABOLIC
   SYNDROME; CARDIOVASCULAR RISK; NEUROPSYCHOLOGICAL IMPAIRMENT; ABDOMINAL
   OBESITY; PHYSICAL-ACTIVITY; INFECTED PATIENTS; DEFICIT SCORES;
   BRAIN-FUNCTION
AB Objective: The Val allele of the Val158Met single-nucleotide polymorphism of the catechol-o-methyltransferase gene (COMT) results in faster metabolism and reduced bioavailability of dopamine (DA). Among persons living with HIV, Val carriers display neurocognitive deficits relative to Met carriers, presumably due to exacerbation of HIV-related depletion of DA. COMT may also impact neurocognition by modulating cardiometabolic function, which is often dysregulated among persons living with HIV. We examined the interaction of COMT, cardiometabolic risk, and nadir CD4 on neurocognitive impairment (NCI) among HIV+ men.
   Methods: Three hundred twenty-nine HIV+ men underwent COMT genotyping and neurocognitive and neuromedical assessments. Cohort-standardized z scores for body mass index, systolic blood pressure, glucose, triglycerides, and high-density lipoprotein cholesterol were averaged to derive a cardiometabolic risk score (CMRS). NCI was defined as demographically adjusted global deficit score of >= 0.5. Logistic regression modeled NCI as a function of COMT, CMRS, and their interaction, covarying for estimated premorbid function, race/ethnicity, and HIV-specific characteristics. Follow-up analysis included the 3-way interaction of COMT, CMRS, and nadir CD4.
   Results: Genotypes were 81 (24.6%) Met/Met, 147 (44.7%) Val/ Met, and 101 (30.7%) Val/Val. COMT interacted with CMRS (P = 0.02) such that higher CMRS increased risk of NCI among Val/Val [odds ratio (OR) = 2.13, P < 0.01], but not Val/Met (OR = 0.93, P > 0.05) or Met/Met (OR = 0.92, P > 0.05) carriers. Among Val/Val, nadir CD4 moderated the effect of CMRS (P < 0.01) such that higher CMRS increased likelihood of NCI only when nadir CD4 <180.
   Discussion: Results suggest a tripartite model by which genetically driven low DA reserve, cardiometabolic dysfunction, and historical immunosuppression synergistically enhance risk of NCI among HIV+ men, possibly due to neuroinflammation and oxidative stress.
C1 [Saloner, Rowan] San Diego State Univ Univ Calif San Diego, San Diego Joint Doctoral Program Clin Psychol, San Diego, CA USA.
   [Saloner, Rowan; Marquine, Maria J.; Sundermann, Erin E.; Hong, Suzi; Heaton, Robert K.; Grant, Igor; Cherner, Mariana] Univ Calif San Diego, Dept Psychiat, San Diego, CA 92103 USA.
   [McCutchan, John Allen] Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA.
   [Ellis, Ronald J.] Univ Calif San Diego, Dept Neurosci, La Jolla, CA 92093 USA.
C3 California State University System; San Diego State University;
   University of California System; University of California San Diego;
   University of California System; University of California San Diego;
   University of California System; University of California San Diego
RP Saloner, R (corresponding author), Univ Calif San Diego, SDSU UC San Diego Joint Doctoral Program Clin Psy, HIV Neurobehav Res Program, 220 Dickinson St,Suite B,Mail Code 8231, San Diego, CA 92103 USA.
EM rsaloner@ucsd.edu
RI Ellis, Ronald/K-3543-2015; cherner, mariana/N-4810-2015
OI Saloner, Rowan/0000-0002-1351-6183
FU NIDA-funded Translational Methamphetamine AIDS Research Center (TMARC)
   [P50DA026306]; NIDA award [R01DA026334]; NIAAA [T32AA013525]; NIMH
   [K23MH105297]; National Institutes of Health [N01 MH22005,
   HHSN271201000036C, HHSN271201000030C]; Icahn School of Medicine at Mount
   Sinai; University of Texas; Imaging Component: Christine
   Fennema-Notestine; University of Washington; CNS HIV Anti-Retroviral
   Therapy Effects Research (CHARTER) [HHSN271201000036C,
   HHSN271201000030C, N01MH22005]
FX Supported by the NIDA-funded Translational Methamphetamine AIDS Research
   Center (TMARC) award P50DA026306 (PI: I.G.), NIDA award R01DA026334 (PI:
   M.C.), and the CNS HIV Anti-Retroviral Therapy Effects Research
   (CHARTER) study awards N01MH22005, HHSN271201000036C, and
   HHSN271201000030C. R.S. is supported by NIAAA award T32AA013525, and
   M.J.M. is supported by NIMH award K23MH105297. The CNS HIV
   Anti-Retroviral Therapy Effects Research was supported by awards N01
   MH22005, HHSN271201000036C, and HHSN271201000030C from the National
   Institutes of Health. The CNS HIV Anti-Retroviral Therapy Effects
   Research (CHARTER) group is affiliated with Johns Hopkins University;
   the Icahn School of Medicine at Mount Sinai; University of California,
   San Diego; University of Texas, Galveston; University of Washington,
   Seattle; Washington University, St. Louis; and is headquartered at the
   University of California, San Diego, and includes: Director: Igor Grant,
   MD; Co-Directors: Scott L. Letendre, MD, Ronald J. Ellis, MD, PhD, and
   Thomas D. Marcotte, PhD; Center Manager: Donald Franklin, Jr;
   Neuromedical Component: Ronald J. Ellis, MD, PhD (P. I.) and J. Allen
   McCutchan, MD; Laboratory and Virology Component: Scott Letendre, MD
   (Co-P. I.) and Davey M. Smith, MD (Co-P. I.); Neurobehavioral Component:
   R. K. H. (P. I.), J. Hampton Atkinson, MD, and Matthew Dawson; Imaging
   Component: Christine Fennema-Notestine, PhD (P. I.), Michael J Taylor,
   PhD, and Rebecca Theilmann, PhD; Data Management Component: Anthony C.
   Gamst, PhD (P. I.) and Clint Cushman; Statistics Component: Ian
   Abramson, PhD (P. I.) and Florin Vaida, PhD; Johns Hopkins University
   Site: Ned Sacktor (P. I.) and Vincent Rogalski; Icahn School of Medicine
   at Mount Sinai Site: Susan Morgello, MD (Co-P. I.) and David Simpson, MD
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   University, St. Louis Site: David Clifford, MD (P. I.), Muhammad
   Al-Lozi, MD, and Mengesha Teshome, MD.
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NR 95
TC 9
Z9 9
U1 1
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1525-4135
EI 1077-9450
J9 JAIDS-J ACQ IMM DEF
JI JAIDS
PD AUG 15
PY 2019
VL 81
IS 5
BP E148
EP E157
DI 10.1097/QAI.0000000000002083
PG 10
WC Immunology; Infectious Diseases
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI); Conference Proceedings Citation Index - Science (CPCI-S)
SC Immunology; Infectious Diseases
GA IQ5GA
UT WOS:000480778900003
PM 31107306
OA Green Submitted, Bronze, Green Accepted
DA 2025-06-11
ER

PT J
AU Pimenta, AM
   Lahortiga-Ramos, F
   Sayon-Orea, C
   Martínez-González, MA
   Sánchez-Villegas, A
AF Pimenta, A. M.
   Lahortiga-Ramos, F.
   Sayon-Orea, C.
   Martinez-Gonzalez, M. A.
   Sanchez-Villegas, A.
TI Depression and metabolic syndrome in participants of the " Seguimiento
   Universidad de Navarra " (SUN) cohort study
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Depression; Metabolic syndrome; Cohort studies; Abdominal obesity; Spain
ID PROSPECTIVE ASSOCIATIONS; SYNDROME COMPONENTS; FTO GENE; SYMPTOMS; RISK;
   INFLAMMATION; METAANALYSIS; VALIDATION; ANXIETY; HEALTH
AB Background: Depression is a major public health concern worldwide and its association with metabolic syndrome (MetS) remains unclear. Thus, we prospectively examined the association between depression and the risk of MetS, according to different diagnosis criteria.
   Methods: This study included 9,237 participants of a Spanish dynamic prospective cohort of adult university graduates [mean (SD) age: 36.7 year (10.7)], initially free of any specific criterion of MetS, who were followed up for a median of 8.3 years. The exposure variables were medical diagnosis of depression at baseline or in the first 2-year follow-up questionnaire. The outcome variable was the incidence of MetS, assessed according to each of three different criteria proposed by: International Diabetes Federation (IDF); National Cholesterol Education Program's Adult Treatment Panel III (NCEP-ATP III); IDF/NCEP-ATP III (updated harmonizing definition). Multivariable-adjusted Relative Risks (RR) of new-onset MetS and their 95% Confidence Intervals (95% CI) were estimated, using Poisson regression models.
   Results: The cumulative incidences of MetS were 475 cases (IDF definition), 288 cases (NCEP-ATP III definition) and 492 cases (update harmonized definition). No association was observed between baseline depression and incidence of MetS, but the presence of depression after 2-years of follow-up was significantly associated with a higher risk of new-onset MetS, according to NCEP-ATP III definition (multivariable-adjusted RR, 2.46; 95% CI, 1.06-5.67).
   Limitations: Diagnosis of depression and MetS were self-reported.
   Conclusions: In this large prospective cohort of Spanish middle-aged adult university graduates, a direct association between depression and the risk of MetS according to NCEP-ATP III definition was found.
C1 [Pimenta, A. M.] Univ Fed Minas Gerais, Dept Maternal Child Nursing & Publ Hlth, Belo Horizonte, MG, Brazil.
   [Pimenta, A. M.; Sanchez-Villegas, A.] Univ Las Palmas Gran Canaria, Res Inst Biomed & Hlth Sci, Las Palmas Gran Canaria, Spain.
   [Lahortiga-Ramos, F.] Univ Clin Navarra, Dept Psychiat & Med Psychol, Pamplona, Spain.
   [Sayon-Orea, C.; Martinez-Gonzalez, M. A.] Univ Navarra, Dept Prevent Med & Publ Hlth, Pamplona, Spain.
   [Martinez-Gonzalez, M. A.; Sanchez-Villegas, A.] Inst Salud Carlos III, Ciber Fisiopatol Obesidad & Nutr CIBER OBN, Madrid, Spain.
   [Martinez-Gonzalez, M. A.] Harvard Univ, Dept Nutr, Harvard TH Chan Sch Publ Hlth, Boston, MA USA.
C3 Universidade Federal de Minas Gerais; Universidad de Las Palmas de Gran
   Canaria; University of Navarra; University of Navarra; CIBER - Centro de
   Investigacion Biomedica en Red; CIBEROBN; Instituto de Salud Carlos III;
   Harvard University; Harvard T.H. Chan School of Public Health
RP Pimenta, AM (corresponding author), Univ Fed Minas Gerais, Sch Nursing, Dept Maternal Child Nursing & Publ Hlth, Av Prof Alfredo Balena 190,4 Andar,Sala 422, BR-30130100 Belo Horizonte, MG, Brazil.
EM adrianomp@ufmg.br
RI Pimenta, Adriano/I-2380-2018; Lahortiga-Ramos, Francisca/H-9363-2017;
   Martinez-Gonzalez, Miguel/AAE-7669-2019; Sanchez-Villegas,
   Almudena/T-6733-2019; Sayon-Orea, Carmen/A-9828-2017
OI Martinez-Gonzalez, Miguel A./0000-0002-3917-9808; Sanchez Villegas,
   Almudena/0000-0001-7733-9238; Sayon-Orea, Carmen/0000-0002-4137-3263
FU Spanish Government-Instituto de Salud Carlos III [RD 06/0045,
   PI10/02658, PI10/02293, PI13/00615, PI14/01668, PI14/01798, PI14/01764,
   PI17/01795, G03/140]; European Regional Development Fund (FEDER) [RD
   06/0045, PI10/02658, PI10/02293, PI13/00615, PI14/01668, PI14/01798,
   PI14/01764, PI17/01795, G03/140]; Navarra Regional Government [27/2011,
   45/2011, 122/2014]; University of Navarra; Carolina Foundation
   (Spain)/Tordesillas Group (Brazil)
FX The SUN Project has received funding from the Spanish
   GovernmentInstituto de Salud Carlos III, and the European Regional
   Development Fund (FEDER) (RD 06/0045, CIBER-OBN, Grants PI10/02658,
   PI10/02293, PI13/00615, PI14/01668, PI14/01798, PI14/01764, PI17/01795,
   and G03/140), the Navarra Regional Government (27/2011, 45/2011,
   122/2014), and the University of Navarra. AMP received a postdoctoral
   fellowship from the Carolina Foundation (Spain)/Tordesillas Group
   (Brazil) for internship development at the Research Institute of
   Biomedical and Health Sciences, University of Las Palmas de Gran
   Canaria, Spain.
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NR 38
TC 8
Z9 8
U1 0
U2 6
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD APR 1
PY 2021
VL 284
BP 183
EP 189
DI 10.1016/j.jad.2021.02.002
EA FEB 2021
PG 7
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA QP1UI
UT WOS:000623621400021
PM 33607508
DA 2025-06-11
ER

PT J
AU Liu, LN
   Tan, RR
   Fang, ZH
   Li, L
   Chen, X
   Luo, YL
   Yang, D
AF Liu, Lini
   Tan, Rongrong
   Fang, Zhenghua
   Li, Li
   Chen, Xi
   Luo, Yinli
   Yang, Dong
TI Prevalence of non-alcoholic fatty liver disease in pediatric mental
   disorder inpatients: a tertiary mental health referral hospital study
SO REVISTA ESPANOLA DE ENFERMEDADES DIGESTIVAS
LA English
DT Article
DE Non-alcoholic fatty liver disease; Pediatric mental disorder;
   Schizophrenia; Bipolar disorder; Depressive disorder; Risk factor
ID RISK-FACTORS; PSYCHOTIC DISORDERS; METABOLIC SYNDROME; SCHIZOPHRENIA;
   CHILDREN; ADOLESCENTS; OBESITY; CHINA
AB Background and aim: studies have revealed a high preva-lence of non-alcoholic fatty liver disease (NAFLD) among adult patients with mental disorders, as well as its associated risk factors. However, little is known about this in the pedi-atric population. The aim of this study was to investigate the prevalence of NAFLD in pediatric inpatients with a mental disorder, and to explore the risk factors. Methods: in this retrospective study, 1,156 pediatric inpa-tients with a mental disorder and admitted to our hospital between January 2020 and December 2021 were included, including inpatients with schizophrenia, bipolar disorder, depressive disorder and other mental disorders. Relevant clinical data were obtained from the electronic medical records. The prevalence rate of NAFLD was calculated and compared with gender, mental disorders types, antipsychot-ics use and comorbidities. Multivariable logistic regression was used to examine risk factors associated with NAFLD. Results: the prevalence of NAFLD in pediatric inpatients with mental disorders was 7.35 % (85/1,156). Patients with NA-FLD were older than those without NAFLD (15.33 +/- 1.75 vs 14.21 +/- 1.95 years-old, p < 0.001). The NAFLD prevalence in participants with schizophrenia (12.11 %) was higher than in participants with bipolar disorder (8.45 %), depressive disor-der (7.06 %) and other mental disorders (2.97 %) (p = 0.002). The NAFLD prevalence was higher in participants who used antipsychotics (8.70 %) than in those who did not (5.45 %) (p = 0.038). Multivariate analysis revealed that older age, body weight (overweight/obese) and dyslipidemia were independent risk factors for NAFLD in pediatric inpatients with mental disorders. Conclusions: the NAFLD prevalence was higher in those pa-tients with schizophrenia and receiving antipsychotic medi-cation. Metabolic factors and longer evolution may explain these differences.
C1 [Liu, Lini; Tan, Rongrong; Fang, Zhenghua; Li, Li; Chen, Xi; Luo, Yinli; Yang, Dong] Brain Hosp Hunan Prov, Peoples Hosp Hunan Prov 2, Dept Psychiat, Changsha, Hunan, Peoples R China.
   [Yang, Dong] Brain Hosp Hunan Prov, Peoples Hosp Hunan Prov 2, Dept Psychiat, Changsha 410011, Hunan, Peoples R China.
RP Yang, D (corresponding author), Brain Hosp Hunan Prov, Peoples Hosp Hunan Prov 2, Dept Psychiat, Changsha 410011, Hunan, Peoples R China.
EM youngdong@163.com
RI Luo, Yinli/JRW-1420-2023; liu, lini/HLQ-4666-2023
FU Key Research Project of Human Province [2020SK2123, 2022SK2044];
   Clinical Medical Center of Depressive Disor-der of Hunan province
   [2021SK4022]; Research Project of Hunan Brain Hospital [2017B10]
FX Funding statement: the study was supported by the Key Research Project
   of Human Province (2020SK2123, 2022SK2044) , Clinical Medical Center of
   Depressive Disor-der of Hunan province (2021SK4022) , and Research
   Project of Hunan Brain Hospital (2017B10) .
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NR 30
TC 1
Z9 1
U1 0
U2 5
PU ARAN EDICIONES, S A
PI MADRID
PA CASTELLO, 128, 28006 MADRID, SPAIN
SN 1130-0108
EI 2340-4167
J9 REV ESP ENFERM DIG
JI Rev. Esp. Enferm. Dig.
PY 2023
VL 115
IS 2
BP 64
EP 69
DI 10.17235/reed.2022.8986/2022
PG 6
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA D7LN0
UT WOS:000970505600004
PM 36281916
OA gold
DA 2025-06-11
ER

PT J
AU Seo, YG
   Lim, H
   Kim, Y
   Ju, YS
   Lee, HJ
   Jang, HB
   Park, SI
   Park, KH
AF Seo, Young-Gyun
   Lim, Hyunjung
   Kim, YoonMyung
   Ju, Young-Su
   Lee, Hye-Ja
   Jang, Han Byul
   Park, Sang Ick
   Park, Kyung Hee
TI The Effect of a Multidisciplinary Lifestyle Intervention on Obesity
   Status, Body Composition, Physical Fitness, and Cardiometabolic Risk
   Markers in Children and Adolescents with Obesity
SO NUTRIENTS
LA English
DT Article
DE intervention; lifestyle; nutrition; exercise; body composition;
   cardiometabolic risk; severe obesity; childhood obesity; adolescents;
   pediatrics
ID METABOLIC SYNDROME; CHILDHOOD OBESITY; DEPRESSION INVENTORY; OVERWEIGHT
   CHILDREN; ENERGY-EXPENDITURE; WEIGHT MANAGEMENT; AEROBIC FITNESS;
   UNITED-STATES; MASS INDEX; PREVALENCE
AB This study aimed to develop a multidisciplinary lifestyle intervention program targeted at children and adolescents with moderate to severe obesity, and assess the additional effects of exercise intervention when compared to usual care. Overall, the 103 enrolled participants were >= 85th percentile of age and sex-specific body mass index (BMI). Participants were divided into groups that received 16 weeks of either usual care or exercise intervention. The BMI z-score of the overall completers decreased by about 0.05 after the 16-week intervention (p = 0.02). After the intervention, only the exercise group had a significantly lower BMI z-score than the baseline score by about 0.1 (p = 0.03), but no significant group by time interaction effects were observed. At the 16-week follow-up, significant group by time interaction effects were observed in percentage body fat (%BF) (beta = -1.52, 95%CI = -2.58--0.45), lean body mass (LM) (beta = 1.20, 95%CI = 0.12-2.29), diastolic blood pressure (beta = -5.24, 95%CI = -9.66--0.83), high-sensitivity C-reactive protein (beta = -1.67, 95%CI = -2.77--1.01), and wall sit test score (beta = 50.74, 95%CI = 32.30-69.18). We developed a moderate-intensity intervention program that can be sustained in the real-world setting and is practically applicable to both moderate and severe obesity. After interventions, the exercise group had lower %BF and cardiometabolic risk markers, and higher LM and leg muscle strength compared to the usual care group.
C1 [Seo, Young-Gyun; Park, Kyung Hee] Hallym Univ, Dept Family Med, Sacred Heart Hosp, Anyang 14068, Gyeonggi Do, South Korea.
   [Lim, Hyunjung] Kyung Hee Univ, Dept Med Nutr, Yongin 17104, Gyeonggi Do, South Korea.
   [Kim, YoonMyung] Yonsei Univ Int Campus, Univ Coll, Incheon 21983, South Korea.
   [Ju, Young-Su] Hallym Univ, Dept Occupat & Environm Med, Sacred Heart Hosp, Anyang 14068, Gyeonggi Do, South Korea.
   [Lee, Hye-Ja; Jang, Han Byul; Park, Sang Ick] Korea Natl Inst Hlth, Ctr Biomed Sci, Cheongju 28159, Chungbuk, South Korea.
C3 Hallym University; Kyung Hee University; Hallym University; Korea
   Disease Control & Prevention Agency (KDCA); Korea National Institute of
   Health (KNIH); Korea CDC Center for Biomedical Science
RP Park, KH (corresponding author), Hallym Univ, Dept Family Med, Sacred Heart Hosp, Anyang 14068, Gyeonggi Do, South Korea.
EM yg035@daum.net; hjlim@khu.ac.kr; yoonkim@yonsei.ac.kr;
   zorro@hallym.ac.kr; hyejalee@korea.kr; greatstar@korea.kr;
   parksi@nih.go.kr; beloved920@gmail.com
RI Park, Kyung/AAU-7867-2020; Lim, Hyunjung/AAJ-4089-2020; Seo,
   Young-Gyun/AAV-3487-2020
OI Park, Kyung Hee/0000-0001-9806-0076; Seo,
   Young-Gyun/0000-0001-8294-1741; Ju, Young-Su/0000-0003-2829-9457
FU Korea Centers for Disease Control and Prevention [2015-ER6401-00]
FX This research was funded by the Korea Centers for Disease Control and
   Prevention, grant number 2015-ER6401-00.
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NR 43
TC 63
Z9 70
U1 2
U2 15
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JAN
PY 2019
VL 11
IS 1
AR 137
DI 10.3390/nu11010137
PG 16
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nutrition & Dietetics
GA HJ8VI
UT WOS:000457477800104
PM 30634657
OA gold, Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Mellon, SH
   Gautam, A
   Hammamieh, R
   Jett, M
   Wolkowitz, OM
AF Mellon, Synthia H.
   Gautam, Aarti
   Hammamieh, Rasha
   Jett, Marti
   Wolkowitz, Owen M.
TI Metabolism, Metabolomics, and Inflammation in Posttraumatic Stress
   Disorder
SO BIOLOGICAL PSYCHIATRY
LA English
DT Review
DE Animal models; Inflammation; Metabolic syndrome; Metabolomics;
   Neuroinflammation; PTSD
ID COMBAT-RELATED PTSD; EARLY-LIFE ADVERSITY; C-REACTIVE PROTEIN;
   PSYCHIATRIC-DISORDERS; MOUSE MODEL; ANIMAL-MODELS; MITOCHONDRIAL
   DYSFUNCTION; PSYCHOSOCIAL STRESS; INSULIN-RESISTANCE; TRAUMA EXPOSURE
AB Posttraumatic stress disorder (PTSD) is defined by classic psychological manifestations, although among the characteristics are significantly increased rates of serious somatic comorbidities, such as cardiovascular disease, immune dysfunction, and metabolic syndrome. In this review, we assess the evidence for disturbances that may contribute to somatic pathology in inflammation, metabolic syndrome, and circulating metabolites (implicating mitochondrial dysfunction) in individuals with PTSD and in animal models simulating features of PTSD. The clinical and preclinical data highlight probable interrelated features of PTSD pathophysiology, including a proinflammatory milieu, metabolomic changes (implicating mitochondrial and other processes), and metabolic dysregulation. These data suggest that PTSD may be a systemic illness, or that it at least has systemic manifestations, and the behavioral manifestations are those most easily discerned. Whether somatic pathology precedes the development of PTSD (and thus may be a risk factor) or follows the development of PTSD (as a result of either shared pathophysiologies or lifestyle adaptations), comorbid PTSD and somatic illness is a potent combination placing affected individuals at increased physical as well as mental health risk. We conclude with directions for future research and novel treatment approaches based on these abnormalities.
C1 [Mellon, Synthia H.] Univ Calif San Francisco, Dept Obstet Gynecol & Reprod Sci, San Francisco, CA USA.
   [Wolkowitz, Owen M.] Univ Calif San Francisco, Dept Psychiat, San Francisco, CA USA.
   [Gautam, Aarti; Hammamieh, Rasha; Jett, Marti] US Army Ctr Environm Hlth Res, US Army Med Res & Mat Command, Integrat Syst Biol, Frederick, MD USA.
C3 University of California System; University of California San Francisco;
   University of California System; University of California San Francisco;
   United States Department of Defense; United States Army
RP Jett, M (corresponding author), US Army Ctr Environm Hlth Res, 568 Doughten Dr, Frederick, MD 21702 USA.
EM marti.jett-tilton.civ@mail.mil
RI Wolkowitz, Owen/J-6649-2013
OI Hammamieh, Rasha/0000-0001-8643-6232; Gautam, Aarti/0000-0003-3132-5599
FU United States Army Medical Research and Materiel Command [09284002];
   United States Army Medical Research and Materiel Command Military
   Operational Medicine Research Program/Defense Health
   Agency/Congressional Special Interests [190040]; Department of Defense
   [W81XWH-11-2-0223, W81XWH-10-1-0021, VB4, T869, MM3]; United States Army
   Research Office
FX This work was supported by the United States Army Medical Research and
   Materiel Command (Grant No. 09284002 to MJ) and the United States Army
   Medical Research and Materiel Command Military Operational Medicine
   Research Program/Defense Health Agency/Congressional Special Interests
   (Grant No. 190040 to MJ). This work was funded by the Department of
   Defense (Grant Nos. W81XWH-11-2-0223 and W81XWH-10-1-0021 to SHM and OMW
   and Grant Nos. VB4, T869, and MM3 to MJ). We acknowledge the United
   States Army Research Office for their support. We also acknowledge Dr.
   Charles Marmar and his research group at New York University Medical
   Center and Dr. Rachel Yehuda and her research group at Mount Sinai
   School of Medicine and the James J. Peters Veterans Affairs Medical
   Center (Bronx, NY) for their tremendous efforts in sample collections
   and clinical assessments as well as all of the collaborators in the
   Systems Biology of PTSD research study. We thank Dr. Julia Scheerer for
   her editorial comments.
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NR 134
TC 123
Z9 131
U1 0
U2 37
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0006-3223
EI 1873-2402
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD MAY 15
PY 2018
VL 83
IS 10
SI SI
BP 866
EP 875
DI 10.1016/j.biopsych.2018.02.007
PG 10
WC Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA GD5QO
UT WOS:000430561800010
PM 29628193
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Shrestha, RM
   Mizoue, T
   Pham, TTP
   Fukunaga, A
   Hoang, DV
   Nguyen, CQ
   Phan, DC
   Hachiya, M
   Huynh, DV
   Le, HX
   Do, HT
   Inoue, Y
AF Shrestha, Rachana Manandhar
   Mizoue, Tetsuya
   Pham, Thuy Thi Phuong
   Fukunaga, Ami
   Hoang, Dong Van
   Nguyen, Chau Que
   Phan, Danh Cong
   Hachiya, Masahiko
   Huynh, Dong Van
   Le, Huy Xuan
   Do, Hung Thai
   Inoue, Yosuke
TI Association between parental absence during childhood and metabolic
   syndrome during adulthood: A cross-sectional study in rural Khanh Hoa,
   Vietnam
SO PLOS ONE
LA English
DT Article
ID ISCHEMIC-HEART-DISEASE; DEVELOPMENTAL ORIGINS; MAJOR DEPRESSION; RISK;
   EXPERIENCES; HEALTH; DEATH
AB BackgroundThis study aimed to determine the association between parental absence during childhood and metabolic syndrome (MetS) in adulthood among middle-aged adults in rural Khanh Hoa province, Vietnam. Given that broader literature on adverse childhood experiences (ACEs) suggests a strong positive association between ACEs and cardiometabolic risk or diseases, we hypothesized that parental absence during childhood, which is a major component of ACEs, is more likely to cause MetS in adulthood. MethodsData were obtained from the baseline survey of the Khanh Hoa Cardiovascular Study, in which 3000 residents aged between 40 to 60 years participated. MetS was assessed using the modified Adult Treatment Panel III (ATP III) criteria. It was considered parental absence if the participants had experienced parental absence due to death, divorce, or out-migration before three or between three to 15 years. We used multiple logistic regression analyses to examine the association between parental absence during childhood and metabolic syndrome during adulthood. ResultsThere was no significant association between parental absence and MetS; adjusted odds ratio [AOR] was 0.97 (95% confidence interval [CI] = 0.76-1.22) for those who experienced parental absence between three to 15 years and the corresponding figure for those who experienced it before three years was 0.93 (95% CI = 0.72-1.20). No significant associations were observed when these were examined for the causes of parental absence. ConclusionThis study did not support our hypothesis of an association between parental absence during childhood and metabolic syndrome during adulthood. Parental absence may not be a predictor of MetS among Vietnamese people in rural communities.
C1 [Shrestha, Rachana Manandhar; Mizoue, Tetsuya; Fukunaga, Ami; Hoang, Dong Van; Inoue, Yosuke] Natl Ctr Global Hlth & Med, Ctr Clin Sci, Dept Epidemiol & Prevent, Tokyo, Japan.
   [Pham, Thuy Thi Phuong; Nguyen, Chau Que; Phan, Danh Cong] Pasteur Inst Nha Trang, Dept Noncommunicable Dis Control & Nutr, Nha Trang, Khanh Hoa, Vietnam.
   [Hachiya, Masahiko] Natl Ctr Global Hlth & Med, Bur Int Hlth Cooperat, Tokyo, Japan.
   [Huynh, Dong Van] Khanh Hoa Ctr Dis Control, Nha Trang, Khanh Hoa, Vietnam.
   [Le, Huy Xuan; Do, Hung Thai] Pasteur Inst Nha Trang, Nha Trang, Khanh Hoa, Vietnam.
C3 Japan Institute for Health Security (JIHS); National Center for Global
   Health & Medicine - Japan; Japan Institute for Health Security (JIHS);
   National Center for Global Health & Medicine - Japan
RP Shrestha, RM (corresponding author), Natl Ctr Global Hlth & Med, Ctr Clin Sci, Dept Epidemiol & Prevent, Tokyo, Japan.
EM mrachana@hosp.ncgm.go.jp; yosuke.yoshi.yosky@gmail.com
RI Hachiya, Masahiko/ABF-8472-2021; Fukunaga, Ami/LFT-3303-2024
OI HUNG, DO THAI/0000-0003-2097-7364; Fukunaga, Ami/0000-0002-8705-0056;
   Manandhar Shrestha, Rachana/0000-0001-9289-8070; Que Chau,
   Nguyen/0000-0001-6276-8662
FU National Center for Global Health and Medicine [19A06]; Pfizer Health
   Research Foundation; Japan Society for the Promotion of Science
   [JP19K20536, JP21J01171, 21K17301]
FX The KhanhHoa Cardiovascular Studyprojectwas fundedby the
   NationalCenterforGlobalHealthand
   Medicine(19A06),PfizerHealthResearchFoundationand the JapanSocietyfor
   thePromotionof
   Science(KAKENHIJP19K20536;JP21J01171;21K17301).Thesefundershad norole in
   the studydesign,executionof the
   study,statisticalanalyses,interpretationof the data ordecisionto
   submitthe manuscriptfor publication
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NR 28
TC 2
Z9 2
U1 0
U2 0
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAR 9
PY 2023
VL 18
IS 3
AR e0282731
DI 10.1371/journal.pone.0282731
PG 10
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 9W4SF
UT WOS:000949067800093
PM 36893153
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Molina-Leyva, A
   Molina-Leyva, I
   Almodovar-Real, A
   Ruiz-Carrascosa, JC
   Naranjo-Sintes, R
   Jimenez-Moleon, JJ
AF Molina-Leyva, Alejandro
   Molina-Leyva, Ignacio
   Almodovar-Real, Ana
   Carlos Ruiz-Carrascosa, Jose
   Naranjo-Sintes, Ramon
   Juan Jimenez-Moleon, Jose
TI Prevalence and Associated Factors of Erectile Dysfunction in Patients
   With Moderate to Severe Psoriasis and Healthy Population: A Comparative
   Study Considering Physical and Psychological Factors
SO ARCHIVES OF SEXUAL BEHAVIOR
LA English
DT Article
DE Anxiety; Organic/medical factors; Psychological factors; Depression;
   Erectile dysfunction; Psoriasis
ID SEXUAL FUNCTIONING QUESTIONNAIRE; INFLAMMATORY-BOWEL-DISEASE;
   QUALITY-OF-LIFE; METABOLIC SYNDROME; CARDIOVASCULAR-DISEASE; DEPRESSIVE
   SYMPTOMS; ANXIETY; RISK; MEN; METAANALYSIS
AB Recent studies have shown that psoriasis is associated with an increased prevalence of erectile dysfunction. To our knowledge, no comparative study has considered simultaneously the role of organic factors and psychological factors in this process. We performed a prospective case series study matched by age to explore the prevalence of erectile dysfunction in psoriasis patients compared to a healthy population and to investigate the role of anxiety, depression, and cardiovascular risk factors in the relationship between psoriasis and erectile dysfunction. The healthy group was matched by frequency to cases by age. Seventy-nine patients with moderate to severe psoriasis and 79 healthy controls participated in the study. Participants completed the Massachusetts General Hospital Sexual Functioning Questionnaire and the Hospital Anxiety and Depression Scale. Psoriasis patients had an increased prevalence of erectile dysfunction in comparison to controls, 34.2 vs. 17.7 % (p < .05). Multivariate analysis showed a significant association between erectile dysfunction and age, smoking and anxiety/depression, but not with psoriasis per se. In conclusion, the higher prevalence of smoking and anxiety/depression among patients with moderate to severe psoriasis probably explains the higher prevalence of erectile dysfunction in this population.
C1 [Molina-Leyva, Alejandro] Complejo Hosp Torrecardenas, Dept Dermatol, Almeria, Spain.
   [Molina-Leyva, Ignacio; Juan Jimenez-Moleon, Jose] Univ Granada, Dept Prevent Med & Publ Hlth, Granada, Spain.
   [Almodovar-Real, Ana] Hosp Santa Ana, Dept Dermatol, Granada, Spain.
   [Molina-Leyva, Alejandro; Carlos Ruiz-Carrascosa, Jose; Naranjo-Sintes, Ramon] Complejo Hosp Univ Granada, Dept Dermatol, Ave Doctor Oloriz 16, Granada 18012, Spain.
   [Juan Jimenez-Moleon, Jose] CIBER Epidemiol & Salud Publ, Madrid, Spain.
C3 Hospital Torrecardenas; University of Granada; University of Granada;
   CIBER - Centro de Investigacion Biomedica en Red; CIBERESP
RP Molina-Leyva, A (corresponding author), Complejo Hosp Torrecardenas, Dept Dermatol, Almeria, Spain.; Molina-Leyva, A (corresponding author), Complejo Hosp Univ Granada, Dept Dermatol, Ave Doctor Oloriz 16, Granada 18012, Spain.
EM alejandromolinaleyva@gmail.com
RI ; Molina-Leyva, Alejandro/M-1213-2014; Jimenez-Moleon, Jose
   J./O-2519-2016
OI Molina Leyva, Ignacio/0000-0003-4424-398X; Molina-Leyva,
   Alejandro/0000-0001-6882-2113; Almodovar Real, Ana
   Maria/0000-0003-4054-7468; Jimenez-Moleon, Jose J./0000-0001-7917-6145
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NR 47
TC 20
Z9 22
U1 0
U2 7
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0004-0002
EI 1573-2800
J9 ARCH SEX BEHAV
JI Arch. Sex. Behav.
PD NOV
PY 2016
VL 45
IS 8
BP 2047
EP 2055
DI 10.1007/s10508-016-0757-8
PG 9
WC Psychology, Clinical; Social Sciences, Interdisciplinary
WE Social Science Citation Index (SSCI)
SC Psychology; Social Sciences - Other Topics
GA DY5WM
UT WOS:000385175100016
PM 27270734
DA 2025-06-11
ER

PT J
AU Schmidt, MV
   Czisch, M
   Sterlemann, V
   Reinel, C
   Sämann, P
   Müller, MB
AF Schmidt, M. V.
   Czisch, M.
   Sterlemann, V.
   Reinel, C.
   Saemann, P.
   Mueller, M. B.
TI Chronic social stress during adolescence in mice alters fat distribution
   in late life: Prevention by antidepressant treatment
SO STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS
LA English
DT Article
DE Chronic stress; metabolic syndrome; obesity; paroxetine; subcutaneous
   fat; visceral fat
ID METABOLIC SYNDROME; MAJOR DEPRESSION; OBESITY; NEUROENDOCRINE; MEN
AB Obesity and visceral fat accumulation are key features of the metabolic syndrome that represents one of the main health problems in western societies due to its neurovascular and cardiovascular complications. Epidemiological studies have identified chronic stress exposure as an important risk factor for the development of obesity and metabolic syndrome, but also psychiatric diseases, especially affective disorders. However, it is still unclear if chronic stress has merely transient or potentially lasting effects on body composition. Here, we investigated the effects of chronic social stress during the adolescent period on body fat composition in mice one year after the cessation of the stressor. We found that stress exposure during the adolescent period decreases subcutaneous fat content, without change in visceral fat, and consequently increases the visceral fat/subcutaneous fat ratio in adulthood. Further, we demonstrated that treatment with a selective serotonin reuptake inhibitor (paroxetine) during stress exposure prevented later effects on body fat distribution. These results from a recently validated chronic stress paradigm in mice provide evidence that stressful experiences during adolescence can alter body fat distribution in adulthood, thereby possibly contributing to an increased risk for metabolic diseases. Antidepressant treatment disrupted this effect underlining the link between the stress hormone system, metabolic homeostasis and affective disorders.
C1 [Schmidt, M. V.] Max Planck Inst Psychiat, RG Mol Stress Physiol, D-80804 Munich, Germany.
C3 Max Planck Society
RP Schmidt, MV (corresponding author), Max Planck Inst Psychiat, RG Mol Stress Physiol, Kraepelinstr 2-10, D-80804 Munich, Germany.
EM mschmidt@mpipsykl.mpg.de
RI ; Mueller, Marianne/AAL-8911-2021
OI Schmidt, Mathias/0000-0002-3788-2268; Mueller,
   Marianne/0000-0002-0269-6131
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NR 19
TC 20
Z9 20
U1 0
U2 5
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 1025-3890
J9 STRESS
JI Stress
PY 2009
VL 12
IS 1
BP 89
EP 94
AR PII 904805506
DI 10.1080/10253890802049343
PG 6
WC Behavioral Sciences; Endocrinology & Metabolism; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Behavioral Sciences; Endocrinology & Metabolism; Neurosciences &
   Neurology
GA 389QO
UT WOS:000262109800009
PM 18951248
DA 2025-06-11
ER

PT J
AU Kuo, WC
   Oakley, LD
   Brown, RL
   Hagen, EW
   Barnet, JH
   Peppard, PE
   Bratzke, LC
AF Kuo, Wan-chin
   Oakley, Linda D.
   Brown, Roger L.
   Hagen, Erika W.
   Barnet, Jodi H.
   Peppard, Paul E.
   Bratzke, Lisa C.
TI Gender Differences in the Relationship Between Financial Stress and
   Metabolic Abnormalities
SO NURSING RESEARCH
LA English
DT Article
DE dyslipidemia; financial stress; gender differences;
   hypertriglyceridemia; metabolic syndrome; obesity
ID CARDIOVASCULAR-DISEASE; OBESITY; DEPRESSION; OXYTOCIN; DURATION; ADULTS;
   RISK
AB Background
   Financial stress is associated with higher prevalence of metabolic abnormalities and cardiovascular disease, but the extent to which this association differs by type of metabolic abnormalities or gender is unclear. Objectives
   The study aims were (a) to examine the association between financial stress and the prevalence of common metabolic abnormalities and (b) to test the association for gender differences. Methods
   A cross-sectional secondary analysis was conducted using data from the Retirement and Sleep Trajectories study, an ancillary study of the Wisconsin Sleep Cohort study. Composite indicator structural equation alpha modeling with a stacking approach was applied in the data analysis. Results
   After controlling for covariates, financial stress was positively associated with the prevalence of abdominal obesity, metabolic syndrome, and dyslipidemia, with significant gender differences. Among men, financial stress was positively associated with the prevalence of hypertriglyceridemia. Among women, financial stress was positively associated with the prevalence of prediabetes, abdominal obesity, metabolic syndrome, and dyslipidemia. Conclusion
   Men living with financial stress are more likely to have hypertriglyceridemia, a specific metabolic abnormality and risk factor for acute cardiovascular events. However, financial stress in women is associated with a broader array of metabolic abnormalities (e.g., dyslipidemia, prediabetes, abdominal obesity, metabolic syndrome), highlighting a potential risk of multiple chronic conditions later in life.
C1 [Kuo, Wan-chin; Oakley, Linda D.; Brown, Roger L.; Bratzke, Lisa C.] Univ Wisconsin, Sch Nursing, Room 5166,Signe Skott Cooper Hall, Madison, WI 53705 USA.
   [Hagen, Erika W.; Barnet, Jodi H.; Peppard, Paul E.] Univ Wisconsin, Dept Populat Hlth Sci, Sch Med & Publ Hlth, Madison, WI 53705 USA.
C3 University of Wisconsin System; University of Wisconsin Madison;
   University of Wisconsin System; University of Wisconsin Madison
RP Kuo, WC (corresponding author), Univ Wisconsin, Sch Nursing, Room 5166,Signe Skott Cooper Hall, Madison, WI 53705 USA.
EM wkuo4@wisc.edu
RI Kuo, Wan-chin/HHN-6428-2022
OI Kuo, Wan-chin/0000-0002-5658-6077
FU National Institutes of Health [R01HL62252, 1R01AG036838, 1UL1RR02501];
   University of Wisconsin-Madison School of Nursing Johnson Research Award
FX The Wisconsin Sleep Cohort and Retirement and Sleep Trajectories studies
   were supported by grants from the National Institutes of Health:
   R01HL62252, 1R01AG036838, and 1UL1RR02501. This research was awarded by
   the University of Wisconsin-Madison School of Nursing Johnson Research
   Award. The authors would like to thank the volunteers who participated
   in the Wisconsin Sleep Cohort and Retirement and Sleep Trajectories
   studies. Editorial support was provided by Joe Wszalek, JD, PhD, the
   Scientific Writing and Scholarship program director at the University of
   Wisconsin-Madison School of Nursing. The authors also thank Anne Ersig,
   RN, PhD, for her contribution to the revision and editing of this
   article.
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NR 50
TC 6
Z9 6
U1 1
U2 11
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0029-6562
EI 1538-9847
J9 NURS RES
JI Nurs. Res.
PD MAR-APR
PY 2021
VL 70
IS 2
BP 123
EP 131
DI 10.1097/NNR.0000000000000489
PG 9
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA SL0BI
UT WOS:000656581400009
PM 33630535
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Nilsson, A
   Salo, I
   Plaza, M
   Björck, I
AF Nilsson, Anne
   Salo, Ilkka
   Plaza, Merichel
   Bjorck, Inger
TI Effects of a mixed berry beverage on cognitive functions and
   cardiometabolic risk markers; A randomized cross-over study in healthy
   older adults
SO PLOS ONE
LA English
DT Article
ID SUPPLEMENTATION IMPROVES MEMORY; ANTIOXIDANT CAPACITY; WORKING-MEMORY;
   LIQUID-CHROMATOGRAPHY; UNIVERSAL RESPONSE; METABOLIC SYNDROME; INSULIN;
   MEN; DISEASE; GLUCOSE
AB Background
   Berries and associated bioactive compounds, e.g. polyphenols and dietary fibre (DF), may have beneficial implications with respect to the metabolic syndrome, including also cognitive functions. The aim of this study was to evaluate effects on cognitive functions and cardiometabolic risk markers of 5 wk intervention with a mixture of berries, in healthy humans.
   Methods
   Forty healthy subjects between 50-70 years old were provided a berry beverage based on a mixture of berries (150g blueberries, 50g blackcurrant, 50g elderberry, 50g lingonberries, 50g strawberry, and 100g tomatoes) or a control beverage, daily during 5 weeks in a randomized crossover design. The control beverage (water based) was matched with respect to monosaccharides, pH, and volume. Cognitive tests included tests of working memory capacity, selective attention, and psychomotor reaction time. Cardiometabolic test variables investigated were blood pressure, fasting blood concentrations of glucose, insulin, blood lipids, inflammatory markers, and markers of oxidative stress. Results
   The daily amounts of total polyphenols and DF from the berry beverage were 795 mg and 11g, respectively. There were no polyphenols or DF in the control beverage. The berry intervention reduced total- and LDL cholesterol compared to baseline (both P<0.05), and in comparison to the control beverage (P<0.005 and P<0.01, respectively). The control beverage increased glucose concentrations (P<0.01) and tended to increase insulin concentrations (P = 0.064) from base line, and increased insulin concentrations in comparison to the berry beverage (P<0.05). Subjects performed better in the working memory test after the berry beverage compared to after the control beverage (P<0.05). No significant effects on the other test variables were observed.
   Conclusions
   The improvements in cardiometabolic risk markers and cognitive performance after the berry beverage suggest preventive potential of berries with respect to type 2 diabetes, cardiovascular disease, and associated cognitive decline. Possibly the polyphenols and DF contributed to the beneficial effects.
C1 [Nilsson, Anne; Bjorck, Inger] Lund Univ, Food Hlth Sci Ctr, Lund, Sweden.
   [Nilsson, Anne] Lund Univ, Dept Food Technol Engn & Nutr, Lund, Sweden.
   [Salo, Ilkka] Lund Univ, Dept Psychol, Lund, Sweden.
   [Plaza, Merichel] Lund Univ, Dept Chem, Ctr Anal & Synth, Lund, Sweden.
   [Plaza, Merichel] Univ Alcala, Dept Analyt Chem Phys Chem & Chem Engn, Madrid, Spain.
C3 Lund University; Lund University; Lund University; Lund University;
   Universidad de Alcala
RP Nilsson, A (corresponding author), Lund Univ, Food Hlth Sci Ctr, Lund, Sweden.; Nilsson, A (corresponding author), Lund Univ, Dept Food Technol Engn & Nutr, Lund, Sweden.
EM anne.nilsson@food-health-science.lu.se
RI Nilsson, Anne/AIA-0822-2022; Plaza, Merichel/J-6770-2013
OI Salo, Ilkka/0000-0003-0943-5484; Nilsson, Anne/0000-0002-9780-7876;
   Plaza, Merichel/0000-0002-9636-6458
FU Antidiabetic Food Centre, a VINNOVA VINN Excellence Center at Lund
   University [2009-04511]
FX This study was supported by the Antidiabetic Food Centre, a VINNOVA VINN
   Excellence Center at Lund University (grant no. 2009-04511). The funders
   had no role in study design, data collection and analysis, decision to
   publish, or preparation of the manuscript. URL:
   http://www.food-health-science.lu.se/en/afc.
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NR 67
TC 67
Z9 70
U1 1
U2 29
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD NOV 15
PY 2017
VL 12
IS 11
AR e0188173
DI 10.1371/journal.pone.0188173
PG 22
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA FM7MC
UT WOS:000415260400067
PM 29141041
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Mayhew, M
   Smith, N
   Fortmann, SP
   Fitzpatrick, SL
AF Mayhew, Meghan
   Smith, Ning
   Fortmann, Stephen P.
   Fitzpatrick, Stephanie L.
TI Mental health diagnosis attenuates weight loss among older adults in a
   digital diabetes prevention program
SO OBESITY SCIENCE & PRACTICE
LA English
DT Article
DE diabetes prevention; lifestyle intervention; mental health
ID PSYCHIATRIC-DISORDERS; METABOLIC SYNDROME; DEPRESSION; OBESITY;
   INDIVIDUALS; VALIDATION; ASSOCIATION; OUTCOMES; RISK; LIFE
AB Objective: Diabetes Prevention Programs (DPP) are effective at reducing diabetes incidence via clinically significant weight loss. Co-morbid mental health condition(s) may reduce the effect of DPP administered in-person and telephonically but this has not been assessed for digital DPP. This report examines the moderating effect of mental health diagnosis on weight change among individuals who enrolled in digital DPP (enrollees) at 12 and 24 months.
   Methods: Secondary analysis of prospective, electronic health record data from a study of digital DPP among adults (N = 3904) aged 65-75 with prediabetes (HbA1c 5.7%-6.4%) and obesity (BMI >= 30 kg/m(2)).
   Results: Mental health diagnosis only moderated the effect of digital DPP on weight change during the first 7 months (p = 0.003) and the effect attenuated at 12 and 24 months. Results were unchanged after adjusting for psychotropic medication use. Among those without a mental health diagnosis, digital DPP enrollees lost more weight than non-enrollees: -4.17 kg (95% CI, -5.22 to -3.13) at 12 months and -1.88 kg (95% CI, -3.00 to -0.76) at 24 months, whereas among individuals with a mental health diagnosis, there was no difference in weight loss between enrollees and non-enrollees at 12 and 24 months (-1.25 kg [95% CI, -2.77 to 0.26] and 0.02 kg [95% CI, -1.69-1.73], respectively).
   Conclusions: Digital DPP appears less effective for weight loss among individuals with a mental health condition, similar to prior findings for in-person and telephonic modalities. Findings suggest a need for tailoring DPP to address mental health conditions.
C1 [Mayhew, Meghan; Smith, Ning; Fortmann, Stephen P.; Fitzpatrick, Stephanie L.] Kaiser Permanente Ctr Hlth Res Northwest Portland, 3800 N Interstate Ave, Portland, OR 97227 USA.
RP Mayhew, M (corresponding author), Kaiser Permanente Ctr Hlth Res Northwest Portland, 3800 N Interstate Ave, Portland, OR 97227 USA.
EM Meghan.H.Mayhew@kpchr.org
OI Fitzpatrick, Stephanie/0000-0003-2740-5502
FU National Institutes of Health (NIH), National Institute of Diabetes and
   Digestive and Kidney Diseases (NIDDK) [1R01DK115237]
FX This study is supported by the National Institutes of Health (NIH),
   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
   (Project Number: 1R01DK115237).
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NR 45
TC 1
Z9 1
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2055-2238
J9 OBES SCI PRACT
JI OBES. SCI. PRACT.
PD JUN
PY 2023
VL 9
IS 3
BP 320
EP 326
DI 10.1002/osp4.644
EA NOV 2022
PG 7
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA I1TL1
UT WOS:000876939300001
PM 37287521
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Dzampaeva, Z
   Datieva, F
   Takoeva, E
   Nartikoeva, M
AF Dzampaeva, Zhanna
   Datieva, Fatima
   Takoeva, Elena
   Nartikoeva, Marina
TI BEHAVIORAL ACTIVITY IN EXPERIMENTAL METABOLIC SYNDROME AND DURING
   TREATMENT WITH COMPLEX PHYTOADAPTOGENS
SO ARCHIV EUROMEDICA
LA English
DT Article
DE Acanthopanax senticosus; dyslipidemia; Glycyrrhiza glabra; hypertension;
   insulin resistance; metabolic syndrome; obesity; Rhodiola rosea
ID LEPTIN
AB The aim of the study was to evaluate behavioral disorders in experimental metabolic syndrome and the possibility of treatment with complex phytoadaptogens (CPhA). The experiment was carried out on 30 male Wistar rats randomly divided into 3 groups: control (Group 1), metabolic syndrome (MS, Group 2), and treatment of metabolic syndrome with CPhA (Group 3). In Groups 2 and 3, the animals were on a diet high in carbohydrates and fats for 16 weeks. Group 3 animals received CPhA for 14 days with drinking water after 16 weeks of the diet. CPhA consist of standard tinctures of Glycyrrhiza glabra, Rhodiola rosea, Acantopanax senticosus in a ratio of 1:2:1. Behavior was analyzed in the open field test (OFT) and the elevated plus maze (EPM), using Realtimer software (OpenScience, Russia). Data were analyzed using GrafPadPrism 8.03 software (USA). The experiment demonstrated that metabolic syndrome is associated with increased anxiety (decrease in horizontal (p=0.017) and vertical (p=0.017) locomotor activity) and fear (increase in immobility time (p=0.011)) in the OFT. Increased anxiety of animals (decreased open arm time (p=0.012) and increased closed arm time (p=0.043)) and emotional stress (increased frequency of defecation (0.017)) relative to control are also confirmed by EPM data. The data obtained in the treatment group (no significant differences with the control), i.e., a decrease in the manifestations of fear and anxiety (increased orientation and exploratory activity), indicate that the complex phytoadaptogens are an effective anxiolytic. The mechanisms that led to this result remain to be explored, highlighting the role of the autonomic nervous system, leptin and ghrelin in behavior and the effect of the complex phytoadaptogens on them.
C1 [Dzampaeva, Zhanna; Datieva, Fatima; Takoeva, Elena; Nartikoeva, Marina] Russian Acad Sci, Dept Chronopathophysiol & Phytopharmacol, Inst Biomed Res, Vladikavkaz Sci Ctr, Moscow, Russia.
C3 Russian Academy of Sciences; Institute of Biomedical Problems of the
   Russian Academy of Sciences; Vladikavkaz Scientific Center
RP Dzampaeva, Z (corresponding author), Russian Acad Sci, Dept Chronopathophysiol & Phytopharmacol, Inst Biomed Res, Vladikavkaz Sci Ctr, Moscow, Russia.
EM dzhanaeva_1991@mail.ru
RI Elena, Takoeva/ABX-7177-2022; Dzampaeva, Zhanna/ABA-4269-2020
OI Takoeva, Elena/0000-0001-7248-5244; Nartikoeva,
   Marina/0000-0001-9235-7303; Dzampaeva, Zhanna/0000-0002-0778-5117
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NR 20
TC 0
Z9 0
U1 0
U2 0
PU EUROPAISCHE WISSENSCHAFTLICHE GESELLSCHAFT EV
PI HANNOVER
PA SUTELSTR 50A, HANNOVER, 30659, GERMANY
SN 2193-3863
EI 2199-885X
J9 ARCH EUROMEDICA
JI Arch. EuroMedica
PY 2022
VL 12
IS 6
DI 10.35630/2022/12/6.5
PG 7
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA C4SD2
UT WOS:000961821400006
OA Bronze
DA 2025-06-11
ER

PT J
AU Todaro, JF
   Shen, BJ
   Niaura, R
   Spiro, A
   Ward, KD
AF Todaro, JF
   Shen, BJ
   Niaura, R
   Spiro, A
   Ward, KD
TI Effect of negative emotions on frequency of coronary heart disease (The
   Normative Aging Study)
SO AMERICAN JOURNAL OF CARDIOLOGY
LA English
DT Article
ID DEPRESSION; MORTALITY; SYMPTOMS; ADULTS; PLASMA; RISK
AB Negative emotions, such as depression and anxiety, have been associated with the development of coronary heart disease (CHD). In multivariate models, negative emotions have predicted CHD outcomes, such as nonfatal myocardial infarction and CHD mortality. Few studies, however, have investigated this relation while controlling for variables associated with the metabolic syndrome or those indicative of sympathetic nervous system activity. We prospectively examined the relation between negative emotions and incident CHD in older men (mean 60.3 +/- 7.9 years) participating in the Normative Aging Study (NAS). Four hundred ninety-eight men who completed the Minnesota Multiphasic Personality Inventory (MMPI) and who participated in a subsequent laboratory assessment were included in the study. All men were not on medication and free of diagnosed CHD and diabetes. Negative emotions were measured by the MMPI Welsh A scale, which is comprised of 39 items measuring symptoms of depression and anxiety. Negative emotion score, sociodemographic characteristics, health behaviors, components of the metabolic syndrome, and stress hormones were used to predict incident CHD over a 3-year follow-up period. During follow-up, 45 CHD events were observed. In unadjusted logistic regression analyses, negative emotions significantly predicted the incidence of CHD (odds ratio [OR] 1.06, 95% confidence interval [CI] 1.01 to 1.10, p = 0.02). After adjusting for potential covariates, negative emotions continued to predict the incidence of CHD (OR 1.06, 95% CI 1.01 to 1.12, p = 0.02) A linear, dose-response relation was observed (chi-square 10.8, degree of freedom 2, p = 0.005): participants who had the highest level of negative emotions experienced the greatest incidence of CHD. (C) 2003 by Excerpta Medica, Inc.
C1 Miriam Hosp, Providence, RI 02903 USA.
   Brown Med Sch, Ctr Behav & Prevent Med, Providence, RI 02903 USA.
   Univ Miami, Dept Psychol, Miami, FL USA.
   Boston Univ, Sch Publ Hlth, Boston, MA USA.
   MAVERIC, Boston VA Healthcare Syst, Boston, MA USA.
   Univ Memphis, Ctr Community Hlth, Memphis, TN 38152 USA.
C3 Lifespan Health Rhode Island; Miriam Hospital; Brown University;
   University of Miami; Boston University; Harvard University; Harvard
   University Medical Affiliates; US Department of Veterans Affairs;
   Veterans Health Administration (VHA); VA Boston Healthcare System;
   University of Memphis
RP Todaro, JF (corresponding author), Brown Med Sch, Ctr Behav & Prevent Med, Coro Bldg,Suite 500,1 Hoppin St, Providence, RI 02903 USA.
RI She, Ji/AAW-6150-2021; Niaura, Raymond/AAE-7319-2019
OI Spiro III, Avron/0000-0003-4080-8621
FU NHLBI NIH HHS [HL37871, 5K23 HL004473-02] Funding Source: Medline; NIA
   NIH HHS [AG02287] Funding Source: Medline
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NR 14
TC 65
Z9 78
U1 0
U2 11
PU EXCERPTA MEDICA INC
PI NEW YORK
PA 650 AVENUE OF THE AMERICAS, NEW YORK, NY 10011 USA
SN 0002-9149
J9 AM J CARDIOL
JI Am. J. Cardiol.
PD OCT 15
PY 2003
VL 92
IS 8
BP 901
EP 906
DI 10.1016/S0002-9149(03)00967-6
PG 6
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 732DW
UT WOS:000185926400001
PM 14556863
DA 2025-06-11
ER

PT J
AU Casseb, GAS
   Ambrósio, G
   Rodrigues, ALS
   Kaster, MP
AF Casseb, Gleicilaine A. S.
   Ambrosio, Gabriela
   Rodrigues, Ana Lucia S.
   Kaster, Manuella P.
TI Levels of 25-hydroxyvitamin D3, biochemical parameters and
   symptoms of depression and anxiety in healthy individuals
SO METABOLIC BRAIN DISEASE
LA English
DT Article
DE Anxiety; Depression; Glucose; Lipid profile; Vitamin D
ID VITAMIN-D-RECEPTOR; TRAIT ANXIETY; PARATHYROID-HORMONE; D
   SUPPLEMENTATION; METABOLIC SYNDROME; DOUBLE-BLIND; RISK; STATE;
   PORTUGUESE; CALCIUM
AB Growing evidence support the role of vitamin D in brain function and behavior. This study investigated the relationship between 25-hydroxyvitamin D-3 [25(OH)D-3] levels, biochemical profile and symptoms of depression and anxiety in healthy individuals. Symptoms of depression were assessed by the Beck Depression Inventory (BDI) and anxiety was evaluated with the State-Trait Anxiety Inventory (STAI). Our sample included 36 individuals, mostly women 27(75%), 36.39 +/- 9.72years old, non-smokers 31(86.1%), body mass index of 26.57 +/- 3.92kg/m(2), 27.95 +/- 7.50% body fat. Participants were divided into those with 25(OH)D-3 levels lower than 40ng/mL (mean 28.16 +/- 7.07) and equal or higher than 40ng/mL (mean 53.19 +/- 6.32). Those with lower 25(OH)D-3 had higher levels of triacylglycerol, triacylglycerol/high density lipoprotein (HDL) ratio, high glucose and homeostatic model assessment of insulin resistance (HOMA-IR) index. No changes were observed in sociodemographic variables, body composition, inflammatory parameters and cortisol. Additionally, in the groups with low and high 25(OH)D-3 levels, STAI state, STAI trait and BDI scores were not statistically different. Levels of 25(OH)D-3 were inversely and independently associated with glucose and HOMA-IR, but not associated with triacylglycerol, depression and anxiety scores. Lower levels of 25(OH)D-3 were associated with dysfunction in glucose metabolism but not with depression and anxiety in healthy individuals.
C1 [Casseb, Gleicilaine A. S.; Ambrosio, Gabriela; Rodrigues, Ana Lucia S.; Kaster, Manuella P.] Univ Fed Santa Catarina, Dept Biochem, BR-88040900 Florianopolis, SC, Brazil.
C3 Universidade Federal de Santa Catarina (UFSC)
RP Kaster, MP (corresponding author), Univ Fed Santa Catarina, Dept Biochem, BR-88040900 Florianopolis, SC, Brazil.
EM manuella.kaster@ufsc.br
RI Rodrigues, Ana Lucia/P-6869-2015; Kaster, Manuella/D-5028-2013
OI Rodrigues, Ana Lucia/0000-0001-6285-8780; Kaster,
   Manuella/0000-0003-0258-6204
FU Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq);
   Coordenacao de Aperfeicoamento de Pessoal de Ensino Superior (CAPES)
FX This study was supported by Conselho Nacional de Desenvolvimento
   Cientifico e Tecnologico (CNPq), and Coordenacao de Aperfeicoamento de
   Pessoal de Ensino Superior (CAPES). MPK and ALSR are CNPq Research
   Fellows.
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NR 67
TC 13
Z9 13
U1 0
U2 5
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0885-7490
EI 1573-7365
J9 METAB BRAIN DIS
JI Metab. Brain Dis.
PD APR
PY 2019
VL 34
IS 2
BP 527
EP 535
DI 10.1007/s11011-018-0371-7
PG 9
WC Endocrinology & Metabolism; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Neurosciences & Neurology
GA HQ1KK
UT WOS:000462156500014
PM 30604028
DA 2025-06-11
ER

PT J
AU Ghanavati, M
   Rahmani, J
   Clark, CCT
   Hosseinabadi, SM
   Rahimlou, M
AF Ghanavati, Matin
   Rahmani, Jamal
   Clark, Cain C. T.
   Hosseinabadi, Susan Mohammadi
   Rahimlou, Mehran
TI Pistachios and cardiometabolic risk factors: A systematic review and
   meta-analysis of randomized controlled clinical trials
SO COMPLEMENTARY THERAPIES IN MEDICINE
LA English
DT Review
DE Pistachios; Cardiometabolic risk factors; Meta-analysis
ID CORONARY-HEART-DISEASE; ENDOTHELIAL FUNCTION; NUT CONSUMPTION;
   CARDIOVASCULAR-DISEASE; BLOOD-PRESSURE; POSTPRANDIAL LIPEMIA; METABOLIC
   SYNDROME; OXIDATIVE STRESS; PREDICTING RISKS; LIPID-LEVELS
AB Background: Previous experimental studies have reported that pistachios can elicit positive effects on lipid profile, blood pressure, and inflammation; however, a meta-analysis of the available evidence has yet to be performed.
   Objective: the aim of this study was to conduct systematic review and meta-analysis of the effect of pistachio enriched diets on cardiometabolic risk factors, such as weight, BMI, blood pressure, serum lipids, blood glucose, and inflammatory biomarkers.
   Design: A literature search was carried out for RCTs in medical databases, including PubMed/MEDLINE, Scopus, and Cochrane databases, with no time limitation up to August 2019, and conducted in accordance with the Preferred Reporting Items of Systematic Reviews and Meta-Analysis guidelines.
   Results: 11 RCTs, with 506 participants, that reported the effect of pistachios consumption on cardiometabolic risk factors were included in this systematic review and meta-analysis. Our findings indicated that pistachios consumption significantly reduced FBS (WMD: -3.73, 95 % CI: -6.99, -0.46, I-2 = 99 %), TC/HDL (WMD: -0.46, 95 % CI: -0.76, -0.15, I-2 = 95 %), LDL/HDL (WMD: -0.24, 95 % CI: -0.38, -0.11, I-2  = 96 %), HbA1C (WMD: -0.14, 95 % CI: -0.26, -0.02, I-2  = 60 %), Insulin (WMD: -2.43, 95 % CI: -4.85, -0.001, I-2  = 58 %), SBP (WMD: -3.10, 95 % CI: -5.35, -0.85,I-2  = 63 %), and MDA (WMD: -0.36, 95 % CI: -0.49, -0.23,I-2  = 0%). Importantly, we did not observe adverse effects of pistachios consumption on BMI or blood pressure.
   Conclusion: This systematic review and meta-analysis demonstrates that pistachios consumption can elicit a beneficial effect on some cardiometabolic risk factors. All previous clinical studies are well designed but some points have still remained unclear including the effects of different pistachios dosages on cardio metabolic risk factors and efficacy of pistachios consumption in preventing endothelial dysfunction. Further examination is required to determine the effect of pistachios consumption on further endothelial function risk factors.
C1 [Ghanavati, Matin] Shahid Beheshti Univ Med Sci, Dept & Fac Nutr Sci & Food Technol, Student Res Comm, Tehran, Iran.
   [Ghanavati, Matin; Rahmani, Jamal; Hosseinabadi, Susan Mohammadi] Shahid Beheshti Univ Med Sci, Fac Nutr Sci & Food Technol, Natl Nutr & Food Technol Res Inst, Dept Clin Nutr & Dietet, Tehran, Iran.
   [Clark, Cain C. T.] Coventry Univ, Ctr Intelligent Healthcare, Coventry CV1 5FB, W Midlands, England.
   [Rahimlou, Mehran] Ahvaz Jundishapur Univ Med Sci, Nutr & Metab Dis Res Ctr, Ahvaz, Iran.
C3 Shahid Beheshti University Medical Sciences; Shahid Beheshti University
   Medical Sciences; Coventry University; Ahvaz Jundishapur University of
   Medical Sciences (AJUMS)
RP Rahimlou, M (corresponding author), Ahvaz Jundishapur Univ Med Sci, Nutr & Metab Dis Res Ctr, Ahvaz, Iran.
EM Rahimlum@gmail.com
RI Rahimlou, Mehran/AAL-4902-2021; Clark, Cain/I-4480-2019; Ghanavati,
   Matin/AAD-6617-2022
OI Rahimlou, Mehran/0000-0002-7861-8287; Ghanavati,
   Matin/0000-0001-7447-3845; Clark, Dr. Cain/0000-0002-6610-4617
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NR 53
TC 45
Z9 46
U1 1
U2 9
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0965-2299
EI 1873-6963
J9 COMPLEMENT THER MED
JI Complement. Ther. Med.
PD AUG
PY 2020
VL 52
AR 102513
DI 10.1016/j.ctim.2020.102513
PG 7
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA OA1IW
UT WOS:000577549300061
PM 32951758
OA Green Published
DA 2025-06-11
ER

PT J
AU Vetter, ML
   Wadden, TA
   Lavenberg, J
   Moore, RH
   Volger, S
   Perez, JL
   Sarwer, DB
   Tsai, AG
AF Vetter, M. L.
   Wadden, T. A.
   Lavenberg, J.
   Moore, R. H.
   Volger, S.
   Perez, J. L.
   Sarwer, D. B.
   Tsai, A. G.
TI Relation of health-related quality of life to metabolic syndrome,
   obesity, depression and comorbid illnesses
SO INTERNATIONAL JOURNAL OF OBESITY
LA English
DT Article
DE quality of life; metabolic syndrome
ID BODY-MASS INDEX; DISEASE; MORTALITY; IMPACT; ASSOCIATION; VALIDATION;
   OVERWEIGHT; SYMPTOMS; SF-12
AB Background: Metabolic syndrome has been associated with impaired health-related quality of life (HRQoL) in several studies. Many studies used only one HRQoL measure and failed to adjust for important confounding variables, including obesity, depression and comorbid conditions.
   Objective: To investigate the relationship between metabolic syndrome and HRQoL using multiple measures. We also sought to determine whether increasing body mass index or diabetes status further modified this relationship.
   Methods: This cross-sectional study included 390 obese participants with elevated waist circumference and at least one other criterion for metabolic syndrome. Of these 390 participants, 269 had metabolic syndrome (that is, they met 3 out of the 5 criteria specified by the NCEP (National Cholesterol Education Program)) and 121 did not. Participants were enrolled in a primary care-based weight-reduction trial. HRQoL was assessed using two generic instruments, the Medical Outcomes Study Short-Form 12 and the EuroQol-5D, as well as an obesity-specific measure, the Impact of Weight on Quality of Life. Differences in HRQoL were compared among participants with and without metabolic syndrome. Multivariable linear regression was used to determine how HRQoL varied according to metabolic syndrome status, and whether factors including weight, depression and burden of comorbid disease modified this relationship.
   Results: Metabolic syndrome was not associated with HRQoL as assessed by any of the measures. In univariable analysis, depression, disease burden and employment status were significantly associated with worse HRQoL on all instruments. In multivariable models, only depression remained significantly associated with reduced HRQoL on all measures. Increasing obesity and diabetes status did not modify the relationship between metabolic syndrome and HRQoL.
   Conclusion: In contrast to previous studies, metabolic syndrome was not associated with impaired HRQoL as assessed by multiple measures. This suggests that metabolic syndrome in itself is not associated with decreased HRQoL, but other factors such as obesity, depression and greater disease burden may significantly influence the quality of life in this population. International Journal of Obesity (2011) 35, 1087-1094; doi:10.1038/ijo.2010.230; published online 2 November 2010
C1 [Vetter, M. L.; Wadden, T. A.; Lavenberg, J.; Moore, R. H.; Volger, S.; Perez, J. L.; Sarwer, D. B.] Univ Penn, Ctr Weight & Eating Disorders, Dept Psychiat, Sch Med, Philadelphia, PA 19104 USA.
   [Vetter, M. L.] Univ Penn, Div Endocrinol Diabet & Metab, Dept Med, Sch Med, Philadelphia, PA 19104 USA.
   [Moore, R. H.] Univ Penn, Dept Epidemiol & Biostat, Ctr Clin Epidemiol & Biostat, Sch Med, Philadelphia, PA 19104 USA.
   [Tsai, A. G.] Univ Colorado, Dept Med, Div Gen Internal Med, Denver, CO USA.
C3 University of Pennsylvania; University of Pennsylvania; University of
   Pennsylvania; University of Colorado System; University of Colorado
   Anschutz Medical Campus; University of Colorado Denver
RP Vetter, ML (corresponding author), Univ Penn, Ctr Weight & Eating Disorders, Dept Psychiat, Sch Med, 3535 Market St,Suite 3108, Philadelphia, PA 19104 USA.
EM marion.vetter@uphs.upenn.edu
RI Cobden, David/AGL-5940-2022; Moore, Richard/E-9653-2010
OI volger, sheri/0000-0002-1689-1173; Wadden, Thomas/0000-0002-0438-4609
FU National Heart, Lung and Blood Institute [U01HL087072-04]; National
   Institute of Diabetes and Digestive and Kidney Diseases
   [5K24DK065018-07]
FX We thank Christopher Vinnard, MD, MPH, MSCE for his editorial
   assistance. This study was supported by grants from the National Heart,
   Lung and Blood Institute (U01HL087072-04) and from the National
   Institute of Diabetes and Digestive and Kidney Diseases
   (5K24DK065018-07).
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NR 49
TC 52
Z9 65
U1 0
U2 10
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0307-0565
EI 1476-5497
J9 INT J OBESITY
JI Int. J. Obes.
PD AUG
PY 2011
VL 35
IS 8
BP 1087
EP 1094
DI 10.1038/ijo.2010.230
PG 8
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 806DA
UT WOS:000293784100010
PM 21042326
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Labenz, C
   Huber, Y
   Michel, M
   Nagel, M
   Galle, PR
   Kostev, K
   Schattenberg, JM
AF Labenz, Christian
   Huber, Yvonne
   Michel, Maurice
   Nagel, Michael
   Galle, Peter R.
   Kostev, Karel
   Schattenberg, Joern M.
TI Nonalcoholic Fatty Liver Disease Increases the Risk of Anxiety and
   Depression
SO HEPATOLOGY COMMUNICATIONS
LA English
DT Article
ID METABOLIC SYNDROME; STEATOHEPATITIS; ADULTS; ASSOCIATION; OBESITY;
   REPRESENTATIVENESS; INFLAMMATION; OVERWEIGHT; HEALTH
AB Nonalcoholic fatty liver disease (NAFLD), depression, and anxiety disorders are frequent diseases, and data on mutual influence are inconsistent. The aim of this study was to explore the incidence of depression and anxiety in a large primary care cohort in Germany and to study the impact of NAFLD over a 10-year time frame. Patients with NAFLD diagnosed between 2010 and 2015 were matched to a cohort without NAFLD controlling for age, sex, physician, index year, and Charlson comorbidity index. The primary outcome of the study was the incidence of depression, anxiety, and first prescription of antidepressant drugs. We compared 19,871 patients with NAFLD to 19,871 matched controls. Within 10 years of the index date, 21.2% of patients with NAFLD and 18.2% of controls were diagnosed with depression (P < 0.001). On regression analysis, the hazard ratio (HR) for incidence of depression was 1.21 (P < 0.001). This association was similar for the endpoint of the first prescription of antidepressant drugs (HR, 1.21;P < 0.001). Anxiety disorders were diagnosed in 7.9% of patients with NAFLD and 6.5% of controls during the observation time (P = 0.003). The HR for incidence of anxiety was 1.23 (P < 0.001). This association remained significant in women (P < 0.001), while there was only a trend in men (HR, 1.15; 95% confidence interval, 0.99-1.34;P < 0.067). The risk of developing anxiety disorders was higher in younger patients.Conclusion:NAFLD constitutes an independent risk factor for emerging depression and anxiety even after controlling for confounding comorbidities.
C1 [Labenz, Christian; Huber, Yvonne; Michel, Maurice; Nagel, Michael; Galle, Peter R.; Schattenberg, Joern M.] Johannes Gutenberg Univ Mainz, Univ Med Ctr, Dept Med 1, Mainz, Germany.
   [Labenz, Christian; Huber, Yvonne; Michel, Maurice; Nagel, Michael; Galle, Peter R.; Schattenberg, Joern M.] Johannes Gutenberg Univ Mainz, Univ Med Ctr, Metab Liver Res Program, Mainz, Germany.
   [Kostev, Karel] IQVIA, Epidemiol, Frankfurt, Germany.
C3 Johannes Gutenberg University of Mainz; Johannes Gutenberg University of
   Mainz; IQVIA
RP Schattenberg, JM (corresponding author), Johannes Gutenberg Univ Mainz, Univ Med Ctr, Dept Med 1, Metab Liver Res Program, Langenbeckstr 1, D-55131 Mainz, Germany.
EM joern.schattenberg@unimedizin-mainz.de
RI Schattenberg, Jörn/C-1301-2013; Galle, Peter/ABE-2872-2021; Kostev,
   Karel/S-4755-2019
OI Kostev, Karel/0000-0002-2124-7227; Galle, Peter
   Robert/0000-0001-8294-0992; Schattenberg, Jorn M./0000-0002-4224-4703
FU University Medical Center Mainz
FX Supported in part by the University Medical Center Mainz (intramural
   funds to J.M.S.).
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NR 40
TC 86
Z9 86
U1 1
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
EI 2471-254X
J9 HEPATOL COMMUN
JI Hepatol. Commun.
PD SEP
PY 2020
VL 4
IS 9
BP 1293
EP 1301
DI 10.1002/hep4.1541
EA JUN 2020
PG 9
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA NO7ID
UT WOS:000543546900001
PM 32923833
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Murphy, KJ
   Parletta, N
AF Murphy, Karen J.
   Parletta, Natalie
TI Implementing a Mediterranean-Style Diet Outside the Mediterranean Region
SO CURRENT ATHEROSCLEROSIS REPORTS
LA English
DT Review
DE Mediterranean diet; MedDiet; MedLey; HELFIMED; Blue zones
ID RANDOMIZED CONTROLLED-TRIAL; CARDIOVASCULAR RISK; METABOLIC SYNDROME;
   MAJOR DEPRESSION; INTERVENTION; ADULTS; WOMEN; PROTOCOL; DISEASE;
   PATTERN
AB Purpose of Review Populations surrounding the Mediterranean basin have traditionally reaped health benefits from a Mediterranean diet (MedDiet), which may benefit Westernized countries plagued by chronic disease. But is it feasible to implement beyond the Mediterranean? To answer this question, we present evidence from randomized controlled trials that achieved high dietary compliance rates with subsequent physical and mental health benefits.
   Recent Findings In the 1960s, the Seven Countries Study identified dietary qualities of Mediterranean populations associated with healthy aging and longevity. The PREDIMED study confirmed reductions in CVD-related mortality with a MedDiet; a meta-analysis in over 4.7 million people showed reduced mortality, CVD-related mortality, and reduced risk of Parkinson's and Alzheimer's disease. Continually emerging research supports the MedDiet's benefits for chronic diseases including metabolic syndrome, cancers, liver disease, type 2 diabetes, depression, and anxiety.
   Summary We summarize components of studies outside the Mediterranean that achieved high compliance to a Med-style diet: dietitian led, dietary education, goal setting, mindfulness; recipe books, meal plans, and food checklists; food hampers; regular contact between volunteers and staff through regular cooking classes; clinic visits; and recipes that are simple, palatable, and affordable. The next step is testing the MedDiet's feasibility in the community. Potential obstacles include access to dietetic/health care professionals, high meat intake, pervasive processed foods, and fast food outlets. For Western countries to promote a Med-style diet, collective support from government, key stakeholders and policy makers, food industry, retailers, and health professionals is needed to ensure the healthiest choice is the easiest choice.
C1 [Murphy, Karen J.; Parletta, Natalie] Univ South Australia, Sch Pharm & Med Sci, GPO Box 2471, Adelaide, SA 5000, Australia.
C3 University of South Australia
RP Murphy, KJ (corresponding author), Univ South Australia, Sch Pharm & Med Sci, GPO Box 2471, Adelaide, SA 5000, Australia.
EM karen.murphy@unisa.edu.au
RI Murphy, Karen/B-5163-2009; Parletta, Natalie/A-7880-2008
OI Murphy, Karen/0000-0002-2589-1319
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NR 53
TC 47
Z9 52
U1 1
U2 69
PU CURRENT MEDICINE GROUP
PI PHILADELPHIA
PA 400 MARKET STREET, STE 700, PHILADELPHIA, PA 19106 USA
SN 1523-3804
EI 1534-6242
J9 CURR ATHEROSCLER REP
JI Curr. Atheroscleros. Rep.
PD JUN
PY 2018
VL 20
IS 6
AR 28
DI 10.1007/s11883-018-0732-z
PG 10
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA GG0TM
UT WOS:000432392000003
PM 29728772
DA 2025-06-11
ER

PT J
AU Matsuda, R
   Kohno, T
   Kohsaka, S
   Fukuoka, R
   Maekawa, Y
   Sano, M
   Takatsuki, S
   Fukuda, K
AF Matsuda, Risa
   Kohno, Takashi
   Kohsaka, Shun
   Fukuoka, Ryoma
   Maekawa, Yuichiro
   Sano, Motoaki
   Takatsuki, Seiji
   Fukuda, Keiichi
TI The prevalence of poor sleep quality and its association with depression
   and anxiety scores in patients admitted for cardiovascular disease: A
   cross-sectional designed study
SO INTERNATIONAL JOURNAL OF CARDIOLOGY
LA English
DT Article
DE Sleep disorders; Depression; Anxiety; Cardiovascular diseases
ID ACUTE MYOCARDIAL-INFARCTION; CORONARY-HEART-DISEASE; CLINICAL
   CARDIOLOGY; ATRIAL-FIBRILLATION; METABOLIC SYNDROME; CHRONIC INSOMNIA;
   RISK-FACTORS; POPULATION; SYMPTOMS; OUTCOMES
AB Background: Poor sleep quality contributes to the development of various cardiovascular conditions. However, its real-world prevalence among cardiovascular inpatients and association with psychological disturbance is unknown. This study aimed to assess the prevalence of poor sleep quality and its association with depression and anxiety in cardiovascular patients, and explored whether sex and cardiovascular comorbidities modified these associations.
   Methods: A total of 1071 patients hospitalized for a broad spectrum of cardiovascular diseases at a single university hospital were assessed (790 men, mean age 64 +/- 14 years). We assessed sleep quality during their index hospitalization period using the Pittsburgh Sleep Quality Index (PSQI); poor sleep quality was defined as PSQI > 5. Depression and anxiety were assessed with the Hospital Anxiety and Depression Scale (HADS).
   Results: The median PSQI score was 5.0 [3.0 - 7.0], and 461 inpatients (43%) had poor sleep quality. Multivariate regression analysis adjusting for patient background, medical risk factors, and laboratory data revealed that poor sleep quality was associated with higher HADS subscores for depression (HADS-depression; odds ratio [OR]: 1.09, 95% confidence interval [CI]: 1.03 - 1.15) and anxiety (HADS-anxiety; OR: 1.17, 95% CI: 1.11 - 1.24). Poor sleep quality was associated with markedly higher HADS-depression among women than men (p value for interaction: 0.008). The association between poor sleep quality and HADS-anxiety was more significant among patients without coronary artery diseases (p value for interaction: 0.017).
   Conclusions: Poor sleep quality was highly prevalent and associated with depression and anxiety in cardiovascular patients. These associations may be modified by sex and the presence of coronary artery diseases. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
C1 [Matsuda, Risa; Kohno, Takashi; Kohsaka, Shun; Fukuoka, Ryoma; Maekawa, Yuichiro; Sano, Motoaki; Takatsuki, Seiji; Fukuda, Keiichi] Keio Univ, Sch Med, Dept Med, Div Cardiol,Shinjuku Ku, 35 Shinanomachi, Tokyo 1608582, Japan.
C3 Keio University
RP Kohno, T (corresponding author), Keio Univ, Sch Med, Dept Med, Div Cardiol,Shinjuku Ku, 35 Shinanomachi, Tokyo 1608582, Japan.
EM kohno.a2@keio.jp
RI takatsuki, seiji/M-1862-2013; Sano, Motoaki/L-3405-2013; Kohsaka,
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NR 33
TC 45
Z9 52
U1 2
U2 22
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0167-5273
EI 1874-1754
J9 INT J CARDIOL
JI Int. J. Cardiol.
PD FEB 1
PY 2017
VL 228
BP 977
EP 982
DI 10.1016/j.ijcard.2016.11.091
PG 6
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Cardiovascular System & Cardiology
GA EJ7NJ
UT WOS:000393408600154
PM 27915216
DA 2025-06-11
ER

PT J
AU Cruz, MME
   Gozal, D
   Salles, C
   Rocha, I
   Ettlin, D
AF Meira E Cruz, Miguel
   Gozal, David
   Salles, Cristina
   Rocha, Isabel
   Ettlin, Dominik
TI Interactions between Insomnia, Sleep Disordered Breathing and
   Cardiometabolic Risk in Patients Complaining of Pain in the Orofacial
   Region
SO ACTA MEDICA PORTUGUESA
LA English
DT Article
DE Cardiometabolic Risk Factors; Facial Pain; Sleep Apnea Syndromes; Sleep
   Initiation and Maintenance Disorders
ID VALIDATION
AB The existence of intersected pathways between the mechanisms of insomnia, sleep-disordered breathing and persistent/chronic pain has been documented. Such concurrence will eventually contribute to a higher burden of cardiometabolic diseases, a main cause of death worldwide. The aim of this study was to evaluate the interactions between insomnia, sleep-disordered breathing, cardiometabolic risk, and psychosocial stress in patients seeking care at an orofacial pain clinic. Anonymized data of 1236 patients seeking care at the orofacial pain unit of the University of Zurich were analysed. Prevalence data was estimated for insomnia, sleep disordered breathing/sleep apnea and increased risk of a combination of insomnia and sleep disordered breathing/sleep apnea, both regarding demographics and cardiometabolic risk factors. Psychosocial stress factors acting as additional cardiometabolic risk factors were assessed. Among patients with persistent orofacial pain, increased risk of combination of insomnia and sleep disordered breathing/ sleep apnea was present in 11.5% of cases, and it was likely to increase psychosocial stress as an aditional independent risk factor for cardiometabolic disorder.
C1 [Meira E Cruz, Miguel] Ctr Cardiovasc Univ Lisboa CCULRISE, Lisbon Fac Med, Sleep Unit, Lisbon, Portugal.
   [Meira E Cruz, Miguel; Salles, Cristina] Int Ctr Clin Sleep Med & Res, Bahiana Sch Med & Publ Hlth, Salvador, Brazil.
   [Gozal, David] Marshall Univ, Joan C Edwards Sch Med, Huntington, WV USA.
   [Rocha, Isabel] Univ Lisbon, Fac Med, Ctr Cardiovasc, Cardiovasc Auton Funct Lab, Lisbon, Portugal.
   [Ettlin, Dominik] Univ Zurich, Ctr Dent Med, Zurich, Switzerland.
C3 Universidade de Lisboa; Marshall University; Universidade de Lisboa;
   University of Zurich
RP Cruz, MME (corresponding author), Ctr Cardiovasc Univ Lisboa CCULRISE, Lisbon Fac Med, Sleep Unit, Lisbon, Portugal.; Cruz, MME (corresponding author), Int Ctr Clin Sleep Med & Res, Bahiana Sch Med & Publ Hlth, Salvador, Brazil.
EM mcruz@medicina.ulisboa.pt
RI Gozal, David/M-9492-2017; Rocha, Isabel/A-4279-2013; Meira e Cruz,
   Miguel/AAS-3687-2020
OI Meira e Cruz, Miguel/0000-0001-6076-0878
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NR 17
TC 2
Z9 2
U1 1
U2 1
PU ORDEM MEDICOS
PI LISBON
PA AV ALMIRANTE GAGO COUTINHO, 151, LISBON, 1749-084, PORTUGAL
SN 0870-399X
EI 1646-0758
J9 ACTA MEDICA PORT
JI Acta Medica Port.
PD JAN
PY 2025
VL 38
IS 1
BP 37
EP 41
DI 10.20344/amp.22350
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA R3G8W
UT WOS:001390384800005
PM 39746313
OA gold
DA 2025-06-11
ER

PT J
AU Wen, Y
   Liu, GH
   Shang, YW
   Wang, Q
AF Wen, Yan
   Liu, Guohui
   Shang, Yawen
   Wang, Qing
TI Association of Depression with Metabolic Syndrome in Highly Educated
   Ethnic Koreans of China: A Case-Control Study
SO NEUROPSYCHIATRIC DISEASE AND TREATMENT
LA English
DT Article
DE depression; metabolic syndrome; ethnic Koreans; self-rating scale for
   depression; waist circumference
ID REPRESENTATIVE SAMPLE; BIPOLAR DISORDER; RISK-FACTORS; ANXIETY;
   PREVALENCE; COMPONENTS; SYMPTOMS; OBESITY; METAANALYSIS; ADULTS
AB Background: Ethnic Koreans in China are a distinct minority group. Highly educated populations are at high risk of depression. The aim of this study was to explore the associations of depression and metabolic syndrome (MS) in highly educated ethnic Koreans in China, and determine whether the associations were dependent on gender.
   Methods: From March 11th to 27th 2017, the natural population of 18-70 year olds was continuously screened at Yanbian Korean Autonomous Region. Those who met the inclusion criteria were invited to complete Zung Self-Rating Depression Scale (SDS). The people with SDS 53 were assigned to depression group and those with SDS <= 53 were assigned to the control group. Demographic characteristics, clinical factors, life-style factors and family history were collected and compared. Besides, associations of depression with MS and its components were estimated by Spearman correlation analysis and logistic regression analysis. Results: The depression group included 367 highly educated ethnic Koreans with depression status and the control group consisted of 388 age-, education-, and gender matched ethnic Koreans without depression. A significantly higher prevalence of MS was observed in males and females with depression status relative to the control subjects (males, 28.5% vs 6.3%, X-2 = 16.162, P-value < 0.001; females, 33.0% vs 7.5%, X-2 = 57.896, P-value < 0.001). Depression status was positively correlated with MS in males (r = 0.311, P-value < 0.01) and females (r = 0.332, P-value < 0.01). After adjusting for potential confounding factors, mild and moderate depression statuses were found to be significantly associated with MS development in male and female ethnic Koreans, respectively.
   Conclusion: Our findings suggest a close link between depression and MS independent of gender in highly educated ethnic Koreans of China.
C1 [Wen, Yan; Shang, Yawen; Wang, Qing] Jilin Univ, Dept Endocrinol, China Japan Union Hosp, 126 Xian Tai St, Changchun 130033, Jilin, Peoples R China.
   [Liu, Guohui] Jilin Univ, Dept Cardiovasc, China Japan Union Hosp, Changchun 130033, Jilin, Peoples R China.
C3 Jilin University; Jilin University
RP Wang, Q (corresponding author), Jilin Univ, Dept Endocrinol, China Japan Union Hosp, 126 Xian Tai St, Changchun 130033, Jilin, Peoples R China.
EM wang_qing@jlu.edu.cn
FU National Key R&D Program of China [2016YFC1305700]; National Key
   Scientific Instrument and Equipment Development Project of China
   [51627808]
FX This work was supported by National Key R&D Program of China (Program
   No. 2016YFC1305700) and the National Key Scientific Instrument and
   Equipment Development Project of China (Program No. 51627808).
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NR 47
TC 1
Z9 1
U1 1
U2 6
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
EI 1178-2021
J9 NEUROPSYCH DIS TREAT
JI Neuropsychiatr. Dis. Treat.
PY 2021
VL 17
BP 57
EP 66
DI 10.2147/NDT.S280716
PG 10
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA QG1PC
UT WOS:000617361700001
PM 33447037
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Kaminska, MS
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   Jurczak, A
AF Kaminska, Magdalena Sylwia
   Cybulska, Anna Maria
   Panczyk, Mariusz
   Baranowska-Bosiacka, Irena
   Chlubek, Dariusz
   Grochans, Elzbieta
   Stanislawska, Marzanna
   Jurczak, Anna
TI The Effect of Whole Blood Lead (Pb-B) Levels on Changes in Peripheral
   Blood Morphology and Selected Biochemical Parameters, and the Severity
   of Depression in Peri-Menopausal Women at Risk of Metabolic Syndrome or
   with Metabolic Syndrome
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Article
DE Pb-B; metabolic syndrome; menopause; depression
ID PUBERTAL DEVELOPMENT; OXIDATIVE STRESS; NATIONAL-HEALTH;
   CARDIOVASCULAR-DISEASE; POSTMENOPAUSAL WOMEN; ALCOHOL-CONSUMPTION;
   ARTERIAL STIFFNESS; VASOMOTOR SYMPTOMS; EXPOSURE; ASSOCIATION
AB The aim of our study was to assess the impact of whole blood lead (Pb-B) levels on changes in peripheral blood morphology and selected biochemical parameters, and the severity of depression in peri-menopausal women at risk of metabolic syndrome (pre-MetS) or with metabolic syndrome (MetS). The study involved 233 women from the general population of the West Pomeranian Province (Poland) aged 44-65 years. The intensity of menopausal symptoms and the severity of depression was examined using the Blatt-Kupperman Index (KI) and the Beck Depression Inventory (BDI). C-reactive protein (CRP), insulin, glucose, glycated hemoglobin (HbA1C), high-density lipoprotein (HDL) and low-density lipoprotein (LDL) cholesterol, triglyceride levels (TG), cortisol, morphology of blood cells and homeostasis model assessment for insulin resistance (HOMA-IR) and Pb-B was measured. Women with MetS had higher levels of glucose, HbA1C, HDL, LDL, TG, cortisol, insulin and higher HOMA-IR. No significant differences in Pb-B were observed between pre-MetS and the control group, and between pre-MetS and the MetS group. A significant correlation was noticed between Pb-B vs. the percentage of monocytes in blood, and blood cortisol levels in women with MetS; Pb-B vs. lymphocyte count and HbA1C in the pre-MetS group, as well as in the BDI scores between the MetS and pre-MetS group. We cannot clearly state that exposure to Pb is an environmental factor that can be considered as a risk factor for MetS in this studied group.
C1 [Kaminska, Magdalena Sylwia] Pomeranian Med Univ, Fac Hlth Sci, Subdept Long Term Care, Dept Social Med, 48 Zolnierska St, PL-71210 Szczecin, Poland.
   [Cybulska, Anna Maria; Grochans, Elzbieta; Stanislawska, Marzanna] Pomeranian Med Univ, Fac Hlth Sci, Dept Nursing, 48 Zolnierska St, PL-71210 Szczecin, Poland.
   [Panczyk, Mariusz] Med Univ Warsaw, Fac Hlth Sci, Dept Educ & Res Hlth Sci, 81 Zwirki & Wigury St, PL-02091 Warsaw, Poland.
   [Baranowska-Bosiacka, Irena; Chlubek, Dariusz] Pomeranian Med Univ, Dept Biochem & Med Chem, 72 Powstancow Wielkopolskich St, PL-70111 Szczecin, Poland.
   [Jurczak, Anna] Pomeranian Med Univ, Fac Hlth Sci, Dept Specialized Nursing, PL-70210 Szczecin, Poland.
C3 Pomeranian Medical University; Pomeranian Medical University; Medical
   University of Warsaw; Pomeranian Medical University; Pomeranian Medical
   University
RP Cybulska, AM (corresponding author), Pomeranian Med Univ, Fac Hlth Sci, Dept Nursing, 48 Zolnierska St, PL-71210 Szczecin, Poland.
EM magdalena.kaminska@pum.edu.pl; anna.cybulska@pum.edu.pl;
   mariusz.panczyk@wum.edu.pl; ika@pum.edu.pl; dchlubek@pum.edu.pl;
   grochans@pum.edu.pl; stamarz@pum.edu.pl; anna.jurczak@pum.edu.pl
RI Chlubek, Dariusz/J-6310-2014; Grochans, Elżbieta/K-8659-2014; Cybulska,
   Anna/AAV-5966-2020; Jurczak, Anna/K-8913-2014; Panczyk,
   Mariusz/B-4412-2011; Kaminska, Magdalena/O-7349-2014; Stanislawska,
   Marzanna/O-7349-2014; Grochans, Elzbieta/M-1593-2014
OI Jurczak, Anna/0000-0003-1935-5285; Panczyk, Mariusz/0000-0003-1830-2114;
   Cybulska, Anna Maria/0000-0002-6912-287X; Baranowska-Bosiacka,
   Irena/0000-0001-9187-8895; Kaminska, Magdalena/0000-0003-4795-033X;
   Stanislawska, Marzanna/0000-0002-4867-9732; Chlubek,
   Dariusz/0000-0003-4497-4395; Grochans, Elzbieta/0000-0002-3679-7002
FU Minister of Science and Higher Education under the name 'Regional
   initiative of excellence' [002/RID/2018/19]
FX This project is financed from the program of the Minister of Science and
   Higher Education under the name 'Regional initiative of excellence' in
   2019-2020 (Project number 002/RID/2018/19; Amount of financing
   12.000.000 PLN).
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NR 101
TC 14
Z9 14
U1 0
U2 14
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD JUL
PY 2020
VL 17
IS 14
AR 5033
DI 10.3390/ijerph17145033
PG 18
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA MX2KZ
UT WOS:000557556200001
PM 32668760
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Brooks, SD
   Hileman, SM
   Chantler, PD
   Milde, SA
   Lemaster, KA
   Frisbee, SJ
   Shoemaker, JK
   Jackson, DN
   Frisbee, JC
AF Brooks, Steven D.
   Hileman, Stanley M.
   Chantler, Paul D.
   Milde, Samantha A.
   Lemaster, Kent A.
   Frisbee, Stephanie J.
   Shoemaker, J. Kevin
   Jackson, Dwayne N.
   Frisbee, Jefferson C.
TI Protection from chronic stress- and depressive symptom-induced vascular
   endothelial dysfunction in female rats is abolished by preexisting
   metabolic disease
SO AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
LA English
DT Article
DE cardiovascular risk factors; chronic stress; clinical depression;
   endothelial dysfunction; metabolic syndrome; sex disparities;
   vasodilation
ID NITRIC-OXIDE; CARDIOVASCULAR-DISEASE; SEX-DIFFERENCES; MODEL;
   MECHANISMS; REACTIVITY; BEHAVIOR; OBESITY; ARTERIOLES; ACTIVATION
AB While it is known that chronic stress and clinical depression are powerful predictors of poor cardiovascular outcomes, recent clinical evidence has identified correlations between the development of metabolic disease and depressive symptoms, creating a combined condition of severely elevated cardiovascular disease risk. In this study, we used the obese Zucker rat (OZRs) and the unpredictable chronic mild stress (UCMS) model to determine the impact of preexisting metabolic disease on the relationship between chronic stress/depressive symptoms and vascular function. Additionally, we determined the impact of metabolic syndrome on sex-based protection from chronic stress/depressive effects on vascular function in female lean Zucker rats (LZRs). In general, vasodilator reactivity was attenuated under control conditions in OZRs compared with LZRs. Although still impaired. conduit arterial and resistance arteriolar dilator reactivity under control conditions in female OZRs was superior to that in male or ovariectomized (OVX) female OZRs, largely because of better maintenance of vascular nitric oxide and prostacyclin levels. However, imposition of metabolic syndrome in combination with UCMS in OZRs further impaired dilator reactivity in both vessel subtypes to a similarly severe extent and abolished any protective effect in female rats compared with male or OVX female rats. The loss of vascular protection in female OZRs with UCMS was reflected in vasodilator metabolite levels, which closely matched those in male and OVX female OZRs subjected to UCMS. These results suggest that presentation of metabolic disease in combination with depressive symptoms can overwhelm the vasoprotection identified in female rats and, thereby, may reflect a severe impairment to normal endothelial function.
   NEW & NOTEWORTHY This study addresses the protection from chronic stress- and depression-induced vascular dysfunction identified in female compared with male or ovariectomized female rats. We determined the impact of preexisting metabolic disease, a frequent comorbidity of clinical depression in humans, on that vascular protection. With preexisting metabolic syndrome, female rats lost all protection from chronic stress/depressive symptoms and became phenotypically similar to male and ovariectomized female rats, with comparably poor vasoactive dilator metabolite profiles.
C1 [Brooks, Steven D.; Hileman, Stanley M.] West Virginia Univ, Dept Physiol & Pharmacol, Morgantown, WV USA.
   [Chantler, Paul D.] West Virginia Univ, Dept Exercise Physiol, Morgantown, WV USA.
   [Milde, Samantha A.; Shoemaker, J. Kevin; Frisbee, Jefferson C.] Univ Western Ontario, Fac Hlth Sci, Schulich Sch Med & Dent, Dept Physiol & Pharmacol, London, ON, Canada.
   [Lemaster, Kent A.; Jackson, Dwayne N.; Frisbee, Jefferson C.] Univ Western Ontario, Fac Hlth Sci, Schulich Sch Med & Dent, Dept Med Biophys, London, ON, Canada.
   [Frisbee, Stephanie J.] Univ Western Ontario, Fac Hlth Sci, Schulich Sch Med & Dent, Dept Pathol & Lab Med, London, ON, Canada.
   [Frisbee, Stephanie J.] Univ Western Ontario, Fac Hlth Sci, Schulich Sch Med & Dent, Dept Epidemiol & Biostat, London, ON, Canada.
   [Shoemaker, J. Kevin] Univ Western Ontario, Sch Kinesiol, London, ON, Canada.
C3 West Virginia University; West Virginia University; Western University
   (University of Western Ontario); Western University (University of
   Western Ontario); Western University (University of Western Ontario);
   Western University (University of Western Ontario); Western University
   (University of Western Ontario)
RP Frisbee, SJ (corresponding author), Univ Western Ontario, 1151 N Richmond Dr, London, ON N6A 5C1, Canada.
EM jfrisbee@uwo.ca
RI Jackson, Dwayne/E-4153-2015; Shoemaker, Kevin/L-2682-2013
OI Frisbee, Jefferson/0000-0003-2751-0599; Shoemaker,
   Kevin/0000-0002-6794-5979; Frisbee, Stephanie/0000-0003-1526-1839
FU American Heart Association Grants [IRG 14330015, PRE 16850005, EIA
   0740129N]; National Institutes of Health Grant [RR-2865AR]; Canadian
   Natural Sciences and Engineering Research Council Grant [R4081A03]
FX This study was supported by American Heart Association Grants IRG
   14330015, PRE 16850005, and EIA 0740129N; National Institutes of Health
   Grant RR-2865AR; and Canadian Natural Sciences and Engineering Research
   Council Grant R4081A03.
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NR 52
TC 16
Z9 17
U1 0
U2 4
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0363-6135
EI 1522-1539
J9 AM J PHYSIOL-HEART C
JI Am. J. Physiol.-Heart Circul. Physiol.
PD MAY
PY 2018
VL 314
IS 5
BP H1085
EP H1097
DI 10.1152/ajpheart.00648.2017
PG 13
WC Cardiac & Cardiovascular Systems; Physiology; Peripheral Vascular
   Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Physiology
GA GP8EQ
UT WOS:000441143200019
PM 29451819
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU de Keijzer, C
   Bauwelinck, M
   Dadvand, P
AF de Keijzer, Carmen
   Bauwelinck, Mariska
   Dadvand, Payam
TI Long-Term Exposure to Residential Greenspace and Healthy Ageing: a
   Systematic Review
SO CURRENT ENVIRONMENTAL HEALTH REPORTS
LA English
DT Review
DE Natural environment; Elderly; Health; Greenspace; Ageing; Park
ID PHYSICAL-ACTIVITY; OLDER-ADULTS; NEIGHBORHOOD ENVIRONMENT; BUILT
   ENVIRONMENT; MENTAL-HEALTH; COGNITIVE FUNCTION; BLUE SPACES; DEPRESSIVE
   SYMPTOMS; ELDERLY RESIDENTS; AIR-POLLUTION
AB Purpose of ReviewWe systematically reviewed the available observational evidence on the association between long-term exposure to residential outdoor greenspace and health at older age and rated the evidence as sufficient, limited, or inadequate.Recent FindingsWe identified 59 studies, ranging from poor to very good quality. The health outcomes included mental health (N=12, of which three were longitudinal studies and eight were rated to be of good quality), cognitive function (N=6; two longitudinal studies, five of good/very good quality), physical capability (N=22; five longitudinal studies, six of good/very good quality), cardiometabolic risk (N=9; one longitudinal study, five of good/very good quality), morbidity (N=11; three longitudinal studies, six of good/very good quality) and perceived wellbeing (N=9; all cross-sectional, two of good quality). The evidence for a beneficial association with greenspace was rated limited for morbidity and inadequate for mental health, cognitive function, physical capability, cardiometabolic risk and perceived wellbeing.SummaryThe reviewed studies provided inadequate/limited but suggestive evidence for a beneficial association between greater long-term greenspace exposure and healthy ageing. This review highlights the need of longitudinal studies that assess the association between long-term greenspace exposure and the trajectory of objective indicators of ageing.
C1 [de Keijzer, Carmen; Dadvand, Payam] Barcelona Biomed Res Pk PRBB, Inst Salud Global Barcelona ISGlobal, Doctor Aiguader 88, Barcelona 08003, Spain.
   [de Keijzer, Carmen; Dadvand, Payam] Univ Pompeu Fabra UPF, Barcelona, Spain.
   [de Keijzer, Carmen; Dadvand, Payam] CIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain.
   [Bauwelinck, Mariska] Res Fdn Flanders FWO, Brussels, Belgium.
   [Bauwelinck, Mariska] Vrije Univ Brussel, Dept Sociol, Interface Demog ID, Brussels, Belgium.
C3 ISGlobal; Pompeu Fabra University; Barcelona Biomedical Research Park;
   Pompeu Fabra University; CIBER - Centro de Investigacion Biomedica en
   Red; CIBERESP; Vrije Universiteit Brussel
RP Dadvand, P (corresponding author), Barcelona Biomed Res Pk PRBB, Inst Salud Global Barcelona ISGlobal, Doctor Aiguader 88, Barcelona 08003, Spain.; Dadvand, P (corresponding author), Univ Pompeu Fabra UPF, Barcelona, Spain.; Dadvand, P (corresponding author), CIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain.
EM payam.dadvand@isglobal.org
RI Dadvand, Payam/O-8053-2018
OI Bauwelinck, Mariska/0000-0002-6117-2135
FU Research Foundation-Flanders (FWO) [11A9718N]; Gustave Boel-Sofina
   Fellowship [V422218N]; Ramon y Cajal fellowships - Spanish Ministry of
   Economy and Competitiveness [RYC-2012-10995]
FX Mariska Bauwelinck is funded by an individual PhD grant supported by the
   Research Foundation-Flanders (FWO) (grant number 11A9718N) and a Gustave
   Boel-Sofina Fellowship (grant number V422218N). PD [RYC-2012-10995] is
   funded by Ramon y Cajal fellowships awarded by the Spanish Ministry of
   Economy and Competitiveness. The funders have not been involved in any
   part of the study design or reporting.
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NR 95
TC 82
Z9 84
U1 9
U2 121
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
EI 2196-5412
J9 CURR ENV HLTH REP
JI Curr.. Environ. Health Rep.
PD MAR
PY 2020
VL 7
IS 1
BP 65
EP 88
DI 10.1007/s40572-020-00264-7
PG 24
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA ME8LU
UT WOS:000544905600006
PM 31981136
DA 2025-06-11
ER

PT J
AU Liu, CC
   Li, Y
   Li, J
   Jin, CG
   Zhong, DP
AF Liu, Chengcheng
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   Li, Jing
   Jin, Chenggang
   Zhong, Deping
TI The Effect of Psychological Burden on Dyslipidemia Moderated by
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SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Article
DE chronic disease; dyslipidemia; depression; NDVI; middle-aged and older
   Chinese; multilevel mixed-effects logistic regression
ID RISK-FACTORS; DEPRESSIVE SYMPTOMS; NATURAL-ENVIRONMENT; METABOLIC
   SYNDROME; CHRONIC DISEASES; ELDERLY-PEOPLE; LIFE-STYLE; PREVALENCE;
   HEALTH; ADULTS
AB Globally, dyslipidemia is now become a leading risk factor for many adverse health outcomes, especially in the middle-aged and elderly. Recent evidence suggests that exposure to greenness and the relief of a psychological burden may decrease the prevalence of dyslipidemia. The objective of our study was to examine whether a green space can moderate the association between mental health status and dyslipidemia. Our study selected the datasets of depression symptoms, dyslipidemia from the China Health and Retirement Longitudinal Study (CHARLS), and the satellite-based normalized difference vegetation index (NDVI) from the 30 m annual maximum NDVI dataset in China in 2018. Ultimately, a total of 10,022 middle-aged and elderly Chinese were involved in our study. Multilevel logistic regressions were performed to examine the association between symptoms of depression and dyslipidemia, as well as the moderate effect of greenness exposure on the association. Our research suggested that adults diagnosed with depression symptoms were more likely to suffer from dyslipidemia. In addition, the NDVI was shown to moderate the effect of depression on dyslipidemia significantly, though the effect was attenuated as depression increased. Regarding the moderate effect of the NDVI on the above association across age, gender, and residence, the findings presented that females, the elderly, and respondents living in urban areas were at a greater risk of having dyslipidemia, although the protective effect of the NDVI was considered. Likewise, the moderate effect of the NDVI gradually decreased as the level of depression increased in different groups. The current study conducted in China provides insights into the association between mental health, green space, and dyslipidemia. Hence, improving mental health and green spaces can be potential targets for medical interventions to decrease the prevalence of dyslipidemia.
C1 [Liu, Chengcheng; Li, Yao; Jin, Chenggang] Beijing Normal Univ, Sch Social Dev & Publ Policy, Beijing 100875, Peoples R China.
   [Li, Jing] Beijing Normal Univ, Fac Geog Sci, Beijing 100875, Peoples R China.
   [Zhong, Deping] Minist Emergency Management Peoples Republ China, Natl Inst Nat Hazards, Beijing 100085, Peoples R China.
C3 Beijing Normal University; Beijing Normal University
RP Zhong, DP (corresponding author), Minist Emergency Management Peoples Republ China, Natl Inst Nat Hazards, Beijing 100085, Peoples R China.
EM ping_bnu@126.com
OI Liu, Chengcheng/0000-0002-4901-2075
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NR 84
TC 3
Z9 3
U1 11
U2 52
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD NOV
PY 2022
VL 19
IS 21
AR 14287
DI 10.3390/ijerph192114287
PG 16
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA 6F5WU
UT WOS:000884131500001
PM 36361165
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Pradeep, C
   Sastha, KRP
   Kumar, SR
   Rathinisha, KU
   Kothai, R
   Arul, B
AF Pradeep, C.
   Sastha, K. R. Prasaath
   Kumar, S. Raj
   Rathinisha, K. U.
   Kothai, Ramalingam
   Arul, Balasubramanian
TI Prevalence of metabolic syndrome and its correlation with sexual
   dysfunction in adult psychiatric patients treated with psychotropics in
   a tertiary care hospital
SO INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
LA English
DT Article; Early Access
ID BIPOLAR DISORDER; SCHIZOPHRENIA; DEPRESSION; HEALTH; INPATIENTS; SUICIDE
AB Background: In the past two decades, there has been a profound increase in the incidence of metabolic disorders among the general population, and psychotropics are also said to play a major role in the development of metabolic syndrome.
   Aim: Determining the prevalence of metabolic syndrome (MetS) and sexual dysfunction (SD) and their correlation in psychiatric patients treated with psychotropics in a tertiary care hospital in Salem region, Tamil Nadu, India.
   Materials and Methods: A cross-sectional study was conducted in the psychiatric department of Vinayaka Mission's Medical College and Hospitals, Salem on patients (n = 108) treated with psychotropics. The sociodemographic information, anthropometric measurements, and laboratory tests for metabolic functions were collected and assessed to determine the presence of metabolic syndrome (as per NCEP ATP III criteria). All the results were statistically analysed and P-value < .05 was considered to be statistically significant.
   Results: The overall prevalence of MetS in the study population was 25.93%. The study found significant relationships between using olanzapine, risperidone, buspirone, and the presence of MetS. Depression was also found to be associated with the development of MetS.
   Conclusion: From this current study, it may be concluded that the psychiatric population is at risk for developing MetS, and the use of atypical antipsychotics (olanzapine, risperidone), anti-anxiety agent (buspirone) and clinical depression is significantly associated with metabolic syndrome. Hence, the metabolic function of psychiatric patients must be regularly assessed for early detection and management of any metabolic abnormalities. The study did not find a significant correlation between SD and MetS in psychiatric patients.
C1 [Pradeep, C.] Vinayaka Missions Res Fdn Deemed Univ, Dept Psychiat, Vinayaka Missions Kirupananda Variyar Med Coll &, Salem, India.
   [Sastha, K. R. Prasaath; Kumar, S. Raj; Rathinisha, K. U.; Kothai, Ramalingam; Arul, Balasubramanian] Vinayaka Missions Res Fdn Deemed Univ, Dept Pharm Practice, Vinayaka Missions Coll Pharm, Salem 636008, Tamil Nadu, India.
C3 Vinayaka Mission's Research Foundation; Vinayaka Mission's Kirupananda
   Variyar Medical College & Hospital; Vinayaka Mission's Research
   Foundation; Vinayaka Mission's College of Pharmacy
RP Arul, B (corresponding author), Vinayaka Missions Res Fdn Deemed Univ, Dept Pharm Practice, Vinayaka Missions Coll Pharm, Salem 636008, Tamil Nadu, India.
EM arul1971@gmail.com
RI Kumar, Sonu/GZA-9110-2022; Kothai, Ramalingam/ABF-4826-2020;
   Balasubramanian, Arul/P-6711-2015
OI Balasubramanian, Arul/0000-0001-6896-5069; , Prasaath
   Sastha/0000-0001-9353-3989
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NR 31
TC 3
Z9 3
U1 0
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1368-5031
EI 1742-1241
J9 INT J CLIN PRACT
JI Int. J. Clin. Pract.
PD 2021 JUL 5
PY 2021
AR e14559
DI 10.1111/ijcp.14559
EA JUL 2021
PG 10
WC Medicine, General & Internal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Pharmacology & Pharmacy
GA TE0LP
UT WOS:000669709900001
PM 34157190
DA 2025-06-11
ER

PT J
AU Brunero, S
   Lamont, S
AF Brunero, Scott
   Lamont, Scott
TI Systematic screening for metabolic syndrome in consumers with severe
   mental illness
SO INTERNATIONAL JOURNAL OF MENTAL HEALTH NURSING
LA English
DT Article
DE metabolic syndrome; physical health; severe mental illness; screening
ID PHYSICAL HEALTH; GUIDELINES; MANAGEMENT; ANTIPSYCHOTICS; SCHIZOPHRENIA;
   PREVALENCE; CLOZAPINE; DISEASE; PEOPLE; TRIAL
AB The high prevalence of metabolic syndrome (MetS) in people with a mental illness has been reported recently in the literature. Gaps have emerged in the widespread use of systematic screening methods that identify this collection of critical risk factors for cardiac and metabolic disorders in people with severe mental illness. A sample (n = 103) of consumers with severe mental illness was screened for MetS using the Metabolic Syndrome Screening Tool and compared to a sample (n = 72) of consumers who were not receiving a systematic approach to screening for MetS. The results demonstrated ad hoc screening of consumers for MetS in the comparison group, potentially leaving patients at risk of cardiac and metabolic disorders being untreated. Mental health nurses are well placed to show leadership in the screening, treatment, and ongoing management of MetS in people with severe mental illness. A potential new speciality role entitled the 'cardiometabolic mental health nurse' is proposed as a means leading to improved outcomes for consumers who have both the complication of physical health problems and a severe mental illness.
C1 [Brunero, Scott] Prince Wales Hosp, Nurse Educ & Res Unit, Randwick, NSW 2031, Australia.
C3 University of New South Wales Sydney; Prince of Wales Hospital (POWH)
RP Brunero, S (corresponding author), Prince Wales Hosp, Nurse Educ & Res Unit, Edmund Blackett Bldg,Room 7,High St, Randwick, NSW 2031, Australia.
EM scott.brunero@sesiahs.health.nsw.gov.au
RI brunero, scott/X-5634-2018; Lamont, Scott/KEH-2123-2024
OI brunero, scott/0000-0003-4156-7014; Lamont, Scott/0000-0003-2497-1314
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NR 39
TC 57
Z9 61
U1 0
U2 11
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1445-8330
J9 INT J MENT HEALTH NU
JI Int. J. Ment. Health Nurs.
PD APR
PY 2009
VL 18
IS 2
BP 144
EP 150
DI 10.1111/j.1447-0349.2009.00595.x
PG 7
WC Nursing; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Psychiatry
GA 415WE
UT WOS:000263966300009
PM 19290978
DA 2025-06-11
ER

PT J
AU Mulvaney, SW
   Dineen, KJ
   Mahadevan, S
   Desronvilles, R Jr
   Olmsted, KLR
AF Mulvaney, Sean W.
   Dineen, Kyle J.
   Mahadevan, Sanjay
   Desronvilles Jr, Roosevelt
   Olmsted, Kristine L. Rae
TI Three-Month Durability of Bilateral Two-Level Stellate Ganglion Blocks
   in Patients with Generalized Anxiety Disorder: A Retrospective Analysis
SO BRAIN SCIENCES
LA English
DT Article
DE stellate ganglion; SGB; anxiety; generalized anxiety disorder; GAD-7;
   two-level cervical sympathetic chain block; 2LCSB; ultrasound
ID POSTTRAUMATIC-STRESS-DISORDER; METABOLIC SYNDROME; BRAIN; RESPONSES;
   SYMPTOMS; RETROPHARYNGEAL; DYSREGULATION; STIMULATION; DEPRESSION;
   MONOCYTES
AB Purpose: Determine if performing ultrasound-guided, bilateral, two-level cervical sympathetic chain blocks (2LCSB) (performed on subsequent days) provides durable improvement in symptoms associated with anxiety. Methods: A retrospective chart review was conducted between January 2022 and November 2024. We identified 114 patients who received bilateral, 2LCSB for anxiety symptoms. Generalized Anxiety Disorder 7-Item Scale (GAD-7) outcome measure scores were collected at baseline and three-months post procedure in 71 males and 43 females. Results: Out of 114 patients, 99 patients (86.8%) showed a long-lasting improvement in their GAD-7 scores. Collected GAD-7 forms had a baseline average of 15.52 (14.99 for males and 16.40 for females), which decreased after three months to an average of 7.28 (6.96 for males and 7.81 for females). This represents a 52% average improvement in anxiety symptoms. Conclusions: In individuals treated with bilateral, 2LCSB, GAD-related symptoms were improved by 52% for at least 3 months regardless of initial anxiety severity.
C1 [Mulvaney, Sean W.] Uniformed Serv Univ Hlth Sci, Dept Mil & Emergency Med, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA.
   [Dineen, Kyle J.; Mahadevan, Sanjay; Desronvilles Jr, Roosevelt] Orthobiol Res Initiat Inc, 11200 Rockville Pike 230, Bethesda, MD 20852 USA.
   [Olmsted, Kristine L. Rae] RTI Int, 3040 E Cornwallis Rd, Res Triangle Pk, NC 27709 USA.
C3 Uniformed Services University of the Health Sciences - USA; Research
   Triangle Institute
RP Dineen, KJ (corresponding author), Orthobiol Res Initiat Inc, 11200 Rockville Pike 230, Bethesda, MD 20852 USA.
EM seanmulvaney@hotmail.com; kyle@rosm.org; smahade3@alumni.jh.edu;
   roosevelt@rosm.org; krolmsted@rti.org
RI Mulvaney, Sean/NHP-1115-2025; Rae Olmsted, Kristine/AAU-3979-2020
OI , Kyle J Dineen/0009-0008-4599-0593; Desronvilles, Roosevelt
   J/0009-0001-7512-4038; Mulvaney, Sean/0000-0002-8762-2835; Rae Olmsted,
   Kristine/0000-0001-7432-1569; Mahadevan, Sanjay/0009-0007-2475-1019
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NR 74
TC 0
Z9 0
U1 0
U2 0
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2076-3425
J9 BRAIN SCI
JI Brain Sci.
PD FEB
PY 2025
VL 15
IS 2
AR 188
DI 10.3390/brainsci15020188
PG 16
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA Y4B2V
UT WOS:001431592000001
PM 40002521
OA gold
DA 2025-06-11
ER

PT J
AU Adil, O
   Kuk, JL
   Ardern, CI
AF Adil, Omar
   Kuk, Jennifer L.
   Ardern, Chris I.
TI Associations between weight discrimination and metabolic health: A cross
   sectional analysis of middle aged adults
SO OBESITY RESEARCH & CLINICAL PRACTICE
LA English
DT Article
DE Weight discrimination; Diabetes; Metabolic syndrome; Obesity; Abdominal
   obesity; Weight stigma
ID OBESITY; STIGMA; INTERNALIZATION; OVERWEIGHT; STRESS; CARDIA; RISK; RACE
AB Background: Concurrent with the recent rise in overweight and obesity, concerns with weight discrimination have arisen. Individuals who have experienced weight discrimination report a host of deteriorations related to physical and psychological health, which may co-exist with behaviours such as increased food consumption and decreases in physical activity that make weight management difficult. What remains less clear, however, is the extent to which metabolic health may be specifically affected, and how this may vary by setting and perceived intensity of the lifetime history of weight discrimination.Method: To address this, a secondary data analysis was performed on 1365 participants from year 25 of the Coronary Artery Disease in Young Adults (CARDIA) study who were living with overweight and obesity. Descriptive statistics and logistic regression analyses were performed on the presence of metabolic syndrome, diabetes, and abdominal obesity, as well as their experience of the weight discrimination.Results: Prevalence of the metabolic syndrome, diabetes, and abdominal obesity was higher among those reporting low and high stress weight discrimination compared to those with no history of weight discrimination. In the adjusted analyses, weight discrimination was associated with a 65% greater likelihood for having meta-bolic syndrome, 85% greater likelihood of diabetes, and between a 2.5-and 3.9-times greater likelihood of abdominal obesity for low and high stress experiences, respectively.Conclusion: Exposure to weight discrimination may worsen metabolic health, as characterized by higher rates of metabolic syndrome and abdominal obesity. These associations may be greater with levels of stress experienced from weight discrimination. Further longitudinal work is necessary to understand the temporal sequence, time lag, and any possible critical periods for weight discrimination on metabolic health.
C1 [Adil, Omar; Kuk, Jennifer L.; Ardern, Chris I.] York Univ, Sch Kinesiol & Hlth Sci, 4700 Keele St, Toronto, ON M3J 1P3, Canada.
   [Adil, Omar] York Univ, Bethune Coll, Sch Kinesiol & Hlth Sci, 222A,4700 Keele St, Toronto, ON M3J 1P3, Canada.
C3 York University - Canada; York University - Canada
RP Adil, O (corresponding author), York Univ, Bethune Coll, Sch Kinesiol & Hlth Sci, 222A,4700 Keele St, Toronto, ON M3J 1P3, Canada.
EM adiloma1@yorku.ca; jennkuk@yorku.ca; cardern@yorku.ca
CR Adam TC, 2007, PHYSIOL BEHAV, V91, P449, DOI 10.1016/j.physbeh.2007.04.011
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NR 34
TC 6
Z9 6
U1 0
U2 5
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1871-403X
EI 1878-0318
J9 OBES RES CLIN PRACT
JI Obes. Res. Clin. Pract.
PD MAR-APR
PY 2022
VL 16
IS 2
BP 151
EP 157
DI 10.1016/j.orcp.2022.02.006
EA APR 2022
PG 7
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 1T5YT
UT WOS:000804804800008
PM 35227638
DA 2025-06-11
ER

PT J
AU Maki, M
   Bjorklund, P
AF Maki, Melissa
   Bjorklund, Pamela
TI Improving Cardiovascular Disease Screening in Community Mental Health
   Centers
SO PERSPECTIVES IN PSYCHIATRIC CARE
LA English
DT Article
DE Cardiometabolic risk; cardiovascular disease (CVD) screening; process
   improvement
ID ANTIPSYCHOTICS
AB PURPOSE: Increased mortality among the seriously mentally ill is largely due to cardiovascular disease (CVD). This applied research project examined a process of CVD screening at a community mental health center, then implemented and evaluated an improved process of identifying and managing CVD risk factors. DESIGN AND METHODS: Patient records (n= 130) were reviewed at baseline and 6 months posteducational intervention and implementation of new monitoring tools. FINDINGS: Statistical analysis showed significant process improvement (p < .001). PRACTICE IMPLICATIONS: Advanced practice registered nurses can design and implement improved CVD screening to mitigate morbidity and mortality in the seriously mentally ill.
C1 [Maki, Melissa] Ctr Human Dev, Duluth, MN USA.
   [Bjorklund, Pamela] Coll St Scholastica, Dept Grad Nursing, Duluth, MN USA.
C3 College of St. Scholastica
RP Maki, M (corresponding author), Ctr Human Dev, Duluth, MN USA.
EM mmaki@css.edu
CR [Anonymous], 2006, PREVENTING CHRONIC D
   Baker Donna L, 2002, AORN J, V75, P825, DOI 10.1016/S0001-2092(06)61639-6
   Barnes TRE, 2007, SCHIZOPHRENIA BULL, V33, P1397, DOI 10.1093/schbul/sbm038
   Buckley PF, 2005, SCHIZOPHR RES, V79, P281, DOI 10.1016/j.schres.2005.04.010
   Chen Y.-H., 2010, SCHIZOPHRENIA B, V37, P1
   Citrome Leslie, 2005, J Psychopharmacol, V19, P102, DOI 10.1177/0269881105059505
   Correll CU, 2007, SCHIZOPHR RES, V92, P103, DOI 10.1016/j.schres.2007.01.004
   Correll Christoph U, 2010, Psychiatr Serv, V61, P892, DOI 10.1176/ps.2010.61.9.892
   Dianis NL, 1998, J NURS CARE QUAL, V12, P49, DOI 10.1097/00001786-199804000-00011
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   Ramsey C., 2000, HEALTHC FINANC MANAG, V54, P2
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NR 18
TC 12
Z9 13
U1 0
U2 8
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0031-5990
EI 1744-6163
J9 PERSPECT PSYCHIATR C
JI Perspect. Psychiatr. Care
PD JUL
PY 2013
VL 49
IS 3
BP 179
EP 186
DI 10.1111/j.1744-6163.2012.00348.x
PG 8
WC Nursing; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Psychiatry
GA 175AR
UT WOS:000321202000006
PM 23819668
DA 2025-06-11
ER

PT J
AU Byrne, ME
   Tanofsky-Kraff, M
   Kelly, NR
   Grammer, AC
   Jaramillo, M
   Mi, SJ
   Stojek, MM
   Shank, LM
   Burke, NL
   Cassidy, O
   Schvey, NA
   Brady, SM
   Demidowich, AP
   Broadney, MM
   Yanovski, SZ
   Yanovski, JA
AF Byrne, Meghan E.
   Tanofsky-Kraff, Marian
   Kelly, Nichole R.
   Grammer, Anne Claire
   Jaramillo, Manuela
   Mi, Sarah J.
   Stojek, Monika M.
   Shank, Lisa M.
   Burke, Natasha L.
   Cassidy, Omni
   Schvey, Natasha A.
   Brady, Sheila M.
   Demidowich, Andrew P.
   Broadney, Miranda M.
   Yanovski, Susan Z.
   Yanovski, Jack A.
TI Pediatric Loss-of-Control Eating and Anxiety in Relation to Components
   of Metabolic Syndrome
SO JOURNAL OF PEDIATRIC PSYCHOLOGY
LA English
DT Article
DE anxiety; loss of control eating; metabolic syndrome; obesity; pediatrics
ID WEIGHT-GAIN; MEAL INTAKE; HIGH-RISK; CHILDREN; BINGE; OVERWEIGHT;
   ADOLESCENTS; BEHAVIORS; STRESS; MAINTENANCE
AB Objective Pediatric loss-of-control (LOC) eating is associated with, and predictive of, gains in adiposity and adverse metabolic outcomes. In addition, some preliminary data suggest that anxiety may exacerbate the relationship of LOC eating with weight and metabolic syndrome (MetS)-related measures. We therefore examined whether anxiety moderated the relationship between LOC eating and body mass index z (BMIz), adiposity, and MetS-related measures in youth. Methods A convenience sample of non-treatment-seeking boys and girls of varying weight strata were interviewed to determine the presence of LOC eating and completed a questionnaire assessing trait anxiety. BMIz and MetS-related measures (blood pressure, triglycerides, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, glucose, and insulin) were measured after an overnight fast. Adiposity was assessed by air displacement plethysmography or dual-energy x-ray absorptiometry. Analyses adjusted for age, sex, race, height, fat mass, and depressive symptoms, as appropriate. Results In all, 379 youths (13.0 +/- 2.8 years; 53% female; BMIz = 0.8 +/- 1.1; 22% with LOC eating) were studied. Anxiety was not significantly related to BMIz, adiposity, or MetS-related measures. However, anxiety and LOC eating interacted such that only among youth with LOC eating, anxiety was positively associated with fasting insulin (p = .02) and insulin resistance (p = .01). The interaction of anxiety and LOC eating was not significantly related to BMIz, adiposity, or any other MetS-related measure (ps = ns). Conclusions Only among non-treatment-seeking youth with LOC eating, anxiety may be associated with increased insulin secretion and insulin resistance. Longitudinal studies are required to confirm these findings and explore mechanisms for these relationships.
C1 [Byrne, Meghan E.; Tanofsky-Kraff, Marian; Kelly, Nichole R.; Jaramillo, Manuela; Stojek, Monika M.; Shank, Lisa M.; Burke, Natasha L.; Cassidy, Omni; Schvey, Natasha A.] USUHS, Dept Med & Clin Psychol, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA.
   [Byrne, Meghan E.; Tanofsky-Kraff, Marian; Kelly, Nichole R.; Grammer, Anne Claire; Jaramillo, Manuela; Mi, Sarah J.; Stojek, Monika M.; Shank, Lisa M.; Burke, Natasha L.; Cassidy, Omni; Schvey, Natasha A.; Brady, Sheila M.; Demidowich, Andrew P.; Broadney, Miranda M.; Yanovski, Jack A.] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Sect Growth & Obes, Program Endocrinol Metab & Genet, Div Intramural Res,NIH,DHHS, Bethesda, MD USA.
   [Shank, Lisa M.] Henry M Jackson Fdn Adv Mil Med HJF, Bethesda, MD USA.
   [Yanovski, Susan Z.] NIDDK, Div Digest Dis & Nutr, NIH, DHHS, Bethesda, MD 20892 USA.
   [Kelly, Nichole R.] Univ Oregon, Counseling Psychol & Human Serv, Eugene, OR 97403 USA.
   [Stojek, Monika M.] Emory Univ, Sch Med, Dept Psychiat, Atlanta, GA 30322 USA.
C3 National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver
   National Institute of Child Health & Human Development (NICHD); Division
   of Intramural Research (DIR); Henry M. Jackson Foundation for the
   Advancement of Military Medicine, Inc; National Institutes of Health
   (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney
   Diseases (NIDDK); University of Oregon; Emory University
RP Tanofsky-Kraff, M (corresponding author), USUHS, Dept Med & Clin Psychol, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA.
EM marian.tanofsky-kraff@usuhs.edu
RI Stojek, Monika/AAB-5990-2021; Burke, Natasha/AAY-2110-2020; Shank,
   Lisa/I-7079-2015
OI Byrne, Meghan/0000-0002-4745-649X; Burke, Natasha/0000-0001-9347-0156;
   Shank, Lisa/0000-0002-6922-7946; Kelly, Nichole/0000-0003-0812-4182;
   Yanovski, Jack/0000-0001-8542-1637; Stojek, Monika/0000-0003-3777-8054
FU Uniformed Services University of the Health Sciences grant [R072IC];
   Intramural Research Program, National Institutes of Health from the
   National Institute of Child Health and Human Development [1ZIAHD000641];
   National Institute of Child Health and Human Development; National
   Institute on Minority Health and Health Disparities; National Institutes
   of Health Clinical Center Bench to Bedside Program; Office of Behavioral
   and Social Sciences Research (OBSSR) of the NIH
FX This work was supported by the Uniformed Services University of the
   Health Sciences grant R072IC (to M.T.K.); Intramural Research Program,
   National Institutes of Health, grant 1ZIAHD000641 from the National
   Institute of Child Health and Human Development with supplemental
   funding from National Institute on Minority Health and Health
   Disparities; the National Institutes of Health Clinical Center Bench to
   Bedside Program; and the Office of Behavioral and Social Sciences
   Research (OBSSR) of the NIH (to J.A.Y.)
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   Zimmet P, 2007, PEDIATR DIABETES, V8, P299, DOI 10.1111/j.1399-5448.2007.00271.x
   2008, APPETITE, V50, P223, DOI DOI 10.1016/J.APPET.2007.07.004
NR 56
TC 19
Z9 19
U1 1
U2 16
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0146-8693
EI 1465-735X
J9 J PEDIATR PSYCHOL
JI J. Pediatr. Psychol.
PD MAR
PY 2019
VL 44
IS 2
BP 220
EP 228
DI 10.1093/jpepsy/jsy077
PG 9
WC Psychology, Developmental
WE Social Science Citation Index (SSCI)
SC Psychology
GA HY1VC
UT WOS:000467904200009
PM 30339233
OA Green Published
DA 2025-06-11
ER

PT J
AU Fung, ACH
   Tse, G
   Cheng, HL
   Lau, ESH
   Luk, A
   Ozaki, R
   So, TTY
   Wong, RYM
   Tsoh, J
   Chow, E
   Wing, YK
   Chan, JCN
   Kong, APS
AF Fung, Annie C. H.
   Tse, Gary
   Cheng, Hiu Lam
   Lau, Eric S. H.
   Luk, Andrea
   Ozaki, Risa
   So, Tammy T. Y.
   Wong, Rebecca Y. M.
   Tsoh, Joshua
   Chow, Elaine
   Wing, Yun Kwok
   Chan, Juliana C. N.
   Kong, Alice P. S.
TI Depressive Symptoms, Co-Morbidities, and Glycemic Control in Hong Kong
   Chinese Elderly Patients With Type 2 Diabetes Mellitus
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Article
DE diabetes; depression; elderly; GDS-15; hypoglycaemia; comorbidities
ID EVALUATION JADE PROGRAM; OLDER-ADULTS; CARDIOVASCULAR-DISEASE;
   MEDICATION ADHERENCE; OXIDATIVE STRESS; MAJOR DEPRESSION; METAANALYSIS;
   RISK; ASSOCIATION; PREVALENCE
AB Background and objectives: Undiagnosed depression is an important comorbidity in type 2 diabetes (T2D) which can be detected using the Geriatric Depression Scale (GDS-15) questionnaire. In this cross-sectional study, we examined the associations of depression using GDS score with control of cardiometabolic risk factors and health status in elderly patients with T2D.
   Setting and participants: Between February and December 2013, patients aged >= 65 years who underwent structured comprehensive assessment as a quality improvement program at the Diabetes Center of a teaching hospital were invited to complete the GDS-15 questionnaire.
   Main outcome measures: Depression was defined as a GDS score >= 7. Demographic data, prior history of co-morbidities, frequency of self-reported hypoglycemia, and attainment of treatment targets defined as HbA(1c), <7%, blood pressure <130/80 mmHg, and LDL-C <2.6 mmol/L were documented.
   Results: Among 325 participants (65% male, median [interquartile range] age: 69 [8] years), 42 (13%) had depression. Patients with depression had longer disease durations (mean +/- SD: 15.1 +/- 9.1 vs. 11.6 +/- 8.1 years, P = 0.02), more frequent self-reported hypoglycemic events (17 vs. 6%, P = 0.03) and were less likely to attain all three treatment targets (0 vs. 16%, P = 0.004) than those without depression. On multivariable analysis, patients with depression had an odds ratio of 2.84 (95% confidence intervals: 1.35-6.00, P = 0.006) of reporting prior history of co-morbidities.
   Conclusion: In elderly patients with T2D, depression was not uncommon especially in those with poor control of risk factors, hypoglycemia, and co-morbidities. Inclusion of GDS-15 questionnaire during structured assessment for complications and risk factors can identify these high-risk patients for more holistic management of their physical and mental health.
C1 [Fung, Annie C. H.; Tse, Gary; Lau, Eric S. H.; Luk, Andrea; Ozaki, Risa; So, Tammy T. Y.; Wong, Rebecca Y. M.; Chow, Elaine; Chan, Juliana C. N.; Kong, Alice P. S.] Chinese Univ Hong Kong, Dept Med & Therapeut, Shatin, Hong Kong, Peoples R China.
   [Tse, Gary; Luk, Andrea; Chan, Juliana C. N.; Kong, Alice P. S.] Chinese Univ Hong Kong, Li Ka Shing Inst Hlth Sci, Shatin, Hong Kong, Peoples R China.
   [Cheng, Hiu Lam; Tsoh, Joshua] Chinese Univ Hong Kong, Sch Publ Hlth & Primary Care, Shatin, Hong Kong, Peoples R China.
   [Luk, Andrea; Chan, Juliana C. N.; Kong, Alice P. S.] Chinese Univ Hong Kong, Hong Kong Inst Diabet & Obes, Shatin, Hong Kong, Peoples R China.
   [Wing, Yun Kwok] Chinese Univ Hong Kong, Dept Psychiat, Shatin, Hong Kong, Peoples R China.
C3 Chinese University of Hong Kong; Chinese University of Hong Kong;
   Chinese University of Hong Kong; Chinese University of Hong Kong;
   Chinese University of Hong Kong
RP Kong, APS (corresponding author), Chinese Univ Hong Kong, Dept Med & Therapeut, Shatin, Hong Kong, Peoples R China.; Kong, APS (corresponding author), Chinese Univ Hong Kong, Li Ka Shing Inst Hlth Sci, Shatin, Hong Kong, Peoples R China.; Kong, APS (corresponding author), Chinese Univ Hong Kong, Hong Kong Inst Diabet & Obes, Shatin, Hong Kong, Peoples R China.
EM alicekong@cuhk.edu.hk
RI Kong, Alice/P-3703-2015; Luk, Andrea/B-5766-2016; Wing, Y./H-9691-2019;
   Lau, Eric S.H./AGZ-2920-2022; Chow, Elaine/HJB-2197-2022; Chan,
   Juliana/B-7918-2016
OI Wing, Yun kwok/0000-0002-5745-5474; TSOH, Joshua/0000-0001-9001-5158;
   Chow, Elaine/0000-0002-4147-3387; Fung, Annie/0000-0001-6688-904X; Lau,
   Eric S. H./0000-0003-1581-5643; Chan, Juliana/0000-0003-1325-1194; Kong,
   Alice/0000-0001-8927-6764
FU Croucher Foundation of Hong Kong
FX We thank the medical and nursing staff at the Prince of Wales Hospital
   Diabetes Centre for their help in recruitment of subjects for this
   study. GT is supported by a Research Fellowship from the Croucher
   Foundation of Hong Kong.
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NR 38
TC 27
Z9 31
U1 1
U2 27
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD MAY 29
PY 2018
VL 9
AR 261
DI 10.3389/fendo.2018.00261
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism
GA GH3MY
UT WOS:000433307900001
PM 29896155
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Faugere, M
   Micoulaud-Franchi, JA
   Faget-Agius, C
   Lançon, C
   Cermolacce, M
   Richieri, R
AF Faugere, M.
   Micoulaud-Franchi, J. -A.
   Faget-Agius, C.
   Lancon, C.
   Cermolacce, M.
   Richieri, R.
TI Quality of life is associated with chronic inflammation in depression: A
   cross-sectional study
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Quality of life; Inflammation; C-reactive protein; Depression
ID C-REACTIVE PROTEIN; METABOLIC SYNDROME; METAANALYSIS; DISORDER; CRP;
   SCHIZOPHRENIA; SCALE; LEVEL
AB Background: Inflammation may play a crucial role in the pathophysiology of depression. However, the association between chronic inflammation and health outcomes in depression remains unclear, particularly for patient-reported outcomes.
   Methods: The aim of this study was to investigate the relationship between quality of life (QoL) (physical and mental health, assessed by the SF-36) and chronic inflammation assessed using C-reactive protein (CRP) in patients with current major depressive disorder.
   Results: One hundred eighty-one patients with depression were enrolled in this study. After adjusting for key socio-demographic, clinical and biological confounding factors, patients with high levels of CRP (> 3.0 mg/L) had worse physical health than those with normal CRP levels (OR = 0.95, 95% CI = 0.92-0.99). Significant associations were found between a higher rate of metabolic syndrome (OR = 0.10, 95% CI = 0.02-0.41) and high CRP levels.
   Limitations: The cut-off point for high cardiovascular risk was used to define the two groups: normal CRP level and high CRP level. CRP was the sole marker of inflammation in this study and was collected at only one time point. The design of this study is cross-sectional and there are no conclusions about the directionality of the association between QoL and inflammation in depression. QoL was assessed only by SF-36 scores.
   Conclusion: This study found an association between SF-36 physical health score and CRP in patients with depression, thereby showing the need to consider physical well-being in depression. This paves the way for interventions to act both on inflammation and QoL in patients with depression.
C1 [Faugere, M.; Faget-Agius, C.; Lancon, C.; Richieri, R.] La Concept Univ Hosp, Dept Psychiat, F-13005 Marseille, France.
   [Faugere, M.; Faget-Agius, C.; Lancon, C.; Richieri, R.] Aix Marseille Univ, Self Perceived Hlth Assessment Res Unit, EA 3279, F-13005 Marseille, France.
   [Micoulaud-Franchi, J. -A.] Pellegrin Univ Hosp, Dept Clin Neurophysiol, Sleep Clin, F-33076 Bordeaux, France.
   [Micoulaud-Franchi, J. -A.] Bordeaux Univ, Res Unit, USR CNRS SANPSY 3413, F-33000 Bordeaux, France.
   [Cermolacce, M.] St Marguerite Univ Hosp, SHU Adult Psychiat, F-13274 Marseille, France.
   [Richieri, R.] Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Psychosis Studies, London, England.
C3 Aix-Marseille Universite; Assistance Publique-Hopitaux de Marseille;
   Aix-Marseille Universite; Universite de Bordeaux; CHU Bordeaux; Centre
   National de la Recherche Scientifique (CNRS); CNRS - National Institute
   for Biology (INSB); Universite de Bordeaux; Aix-Marseille Universite;
   Assistance Publique-Hopitaux de Marseille; University of London; King's
   College London
RP Faugere, M (corresponding author), CHU La Concept, Pole Psychiat Ctr, Serv Pr C Lancon, 147 Bd Baille, F-13005 Marseille, France.
EM melanie.faugere@ap-hm.fr
RI Faugere, Melanie/JCP-3459-2023; richieri, raphaelle/E-4707-2015
OI MICOULAUD-FRANCHI, Jean-Arthur/0000-0002-5203-8444; Faugere,
   Melanie/0000-0001-5567-8650; RICHIERI, Raphaelle/0000-0002-3901-7016
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NR 28
TC 16
Z9 18
U1 0
U2 8
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD FEB
PY 2018
VL 227
BP 494
EP 497
DI 10.1016/j.jad.2017.11.061
PG 4
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA FV1LP
UT WOS:000424323600066
PM 29156363
DA 2025-06-11
ER

PT J
AU Stanley, SH
   Laugharne, JDE
   Chapman, M
   Balaratnasingam, S
AF Stanley, Susanne H.
   Laugharne, Jonathan D. E.
   Chapman, Murray
   Balaratnasingam, Sivasankaran
TI Kimberley Indigenous mental health: An examination of metabolic syndrome
   risk factors
SO AUSTRALIAN JOURNAL OF RURAL HEALTH
LA English
DT Article
DE Indigenous Health; mental health; primary health care; remote health;
   research and education
ID CARDIOVASCULAR-DISEASE; OBESITY; AUSTRALIANS; PREVALENCE; ILLNESS;
   SCHIZOPHRENIA; POPULATIONS; DEFINITION; PROGRAM; PEOPLE
AB Objective: There is an increased risk of physical health comorbidities in people with a mental illness. This paper examines the metabolic syndrome parameters for the general population, indigenous Australians and people with a mental illness, and compares them to a sample of predominantly indigenous adults with mental health problems.
   Design: A longitudinal (24 month) audit of patient medical records was conducted between February 2011 and March 2013.
   Setting: The Kimberley Mental Health and Drug Service in Broome, Western Australia.
   Participants: Largely indigenous adults with a mental illness. Sample numbers increased from 56 at baseline (80% indigenous) to 136 at 18 months (70% indigenous).
   Main outcome measures: Waist circumference, blood pressure, fasting lipids, and fasting blood glucose.
   Results: Preliminary assessment of the data indicates a high percentage of abnormalities at baseline and at the 18 month period on all four parameters, yet not all patients were assessed on a regular basis.
   Conclusions: Abnormalities in metabolic profiles consistent with the non-Indigenous mental health population were found. There are considerable challenges to implementing regular monitoring of physical and metabolic profiles of indigenous people in rural and remote communities.
C1 [Stanley, Susanne H.; Laugharne, Jonathan D. E.; Chapman, Murray; Balaratnasingam, Sivasankaran] Univ Western Australia, Fremantle Hosp, Sch Psychiat & Clin Neurosci, T Block,L7,1 Alma St, Fremantle, WA 6160, Australia.
   [Chapman, Murray; Balaratnasingam, Sivasankaran] Kimberley Mental Hlth & Drug Serv, Broome, WA, Australia.
C3 South Metropolitan Health Service; Fiona Stanley Fremantle Hospitals
   Group; Fremantle Hospital; University of Western Australia
RP Stanley, SH (corresponding author), Univ Western Australia, Fremantle Hosp, Sch Psychiat & Clin Neurosci, T Block,L7,1 Alma St, Fremantle, WA 6160, Australia.
EM Susanne.Stanley@uwa.edu.au
RI Stanley, Susanne/H-5882-2014
OI Stanley, Susanne/0000-0002-0404-9018
FU WA Mental Health Commission
FX This project was funded by the WA Mental Health Commission.
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NR 35
TC 2
Z9 2
U1 2
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1038-5282
EI 1440-1584
J9 AUST J RURAL HEALTH
JI Aust. J. Rural Health
PD OCT
PY 2016
VL 24
IS 5
BP 300
EP 305
DI 10.1111/ajr.12270
PG 6
WC Public, Environmental & Occupational Health; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; Nursing
GA EC7AY
UT WOS:000388289400003
PM 26689845
DA 2025-06-11
ER

PT J
AU Ho, YL
   Wu, CC
   Yen, RF
   Hung, SR
   Chen, MF
   Huang, PJ
AF Ho, YL
   Wu, CC
   Yen, RF
   Hung, SR
   Chen, MF
   Huang, PJ
TI Comparison of ischemic patterns in myocardial bridge and syndrome X:
   Evaluation by dobutamine stress echocardiography and stress thallium-201
   SPECT
SO JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
LA English
DT Article
DE syndrome X; myocardial bridge; dobutamine stress echocardiography;
   stress thallium-201 SPECT
ID EMISSION COMPUTED-TOMOGRAPHY; CORONARY-ARTERY DISEASE; LEFT-VENTRICULAR
   HYPERTROPHY; CHEST PAIN; INFARCTION; ATHEROSCLEROSIS; DYSFUNCTION;
   MILKING; SCANS
AB Background and purpose: Ischemic patterns in patients with syndrome X are thought to differ from those in patients with myocardial bridge, because the mechanisms of coronary flow reduction in these two diseases are different. The aim of this study was to compare the ischemic patterns in patients with syndrome X and those with myocardial bridge through the use of dobutamine stress echocardiography (DSE) and stress thallium-201 single-photon emission computed tomography (SPECT).
   Methods: Twenty-six patients with typical angina and stress-induced ST-segment depression were enrolled. All patients underwent coronary angiography, DSE, stress thallium-201 SPECT within 7 days after enrollment.
   Results: Of the 26 patients enrolled, 10 had myocardial bridge of the left anterior descending artery and 16 had syndrome X. Among patients with myocardial bridge, myocardial dyssynergy was found by DSE in five patients and reversible or fixed thallium-201 perfusion defects were found in four. Seven patients with myocardial bridge had reverse redistribution patterns on thallium-201 scintigraphy. In the 16 patients with syndrome X, myocardial dyssynergy was found by DSE in only one patient (p = 0.018 vs myocardial bridge group) and reversible or fixed thallium-201 perfusion defects were found in nine (p > 0.05 vs myocardial bridge group). Four patients with syndrome X had reverse redistribution patterns on thallium-201 scintigraphy. The resting left ventricular end-diastolic pressure was higher in patients with myocardial bridge than in those with syndrorne X (17 +/- 4 vs 12 +/- 5 mm Hg, p = 0.02).
   Conclusions: The most common ischemic patterns in patients with syndrome X were chest pain and stress-induced ST-segment depression, followed by myocardial perfusion defects. Dobutamine-induced dyssynergy was rare. Left ventricular end diastolic pressure elevation and dobutamine-induced wall motion abnormalities were more common in patients with myocardial bridge than in those with syndrome X.
C1 Natl Taiwan Univ Hosp, Dept Internal Med Cardiol, Taipei, Taiwan.
   Natl Taiwan Univ Hosp, Dept Nucl Med, Taipei, Taiwan.
   Natl Taiwan Univ Hosp, Dept Nucl Med, Taipei, Taiwan.
C3 National Taiwan University; National Taiwan University Hospital;
   National Taiwan University; National Taiwan University Hospital;
   National Taiwan University; National Taiwan University Hospital
RP Huang, PJ (corresponding author), Natl Taiwan Univ Hosp, Dept Internal Med Cardiol, 7 Chung-Shan S Rd, Taipei, Taiwan.
RI Wu, Chun-Ying/AAX-5077-2021
OI HO, YI-LWUN/0000-0002-8936-9570; YEN, RUOH-FANG/0000-0003-1648-6482
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NR 37
TC 3
Z9 4
U1 0
U2 0
PU EXCERPTA MEDICA ASIA LTD
PI CHAI WAN
PA 19/F, EIGHT COMMERCIAL TOWER, 8 SUN YIP ST, CHAI WAN, HONG KONG
SN 0929-6646
J9 J FORMOS MED ASSOC
JI J. Formos. Med. Assoc.
PD FEB
PY 2001
VL 100
IS 2
BP 83
EP 88
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 423YX
UT WOS:000168206300002
PM 11393106
DA 2025-06-11
ER

PT J
AU Carpiniello, B
   Pinna, F
   Velluzzi, F
   Loviselli, A
AF Carpiniello, B.
   Pinna, F.
   Velluzzi, F.
   Loviselli, A.
TI Mental disorders in patients with metabolic syndrome. The key role of
   central obesity
SO EATING AND WEIGHT DISORDERS-STUDIES ON ANOREXIA BULIMIA AND OBESITY
LA English
DT Article
DE Metabolic syndrome; central obesity; current prevalence; mental
   disorders; anxiety disorders; mood disorders; binge eating disorders
ID QUALITY-OF-LIFE; DEPRESSIVE SYMPTOMS; PSYCHIATRIC COMORBIDITY;
   NATIONAL-HEALTH; PREVALENCE; RISK; ANXIETY; WOMEN; POPULATION;
   OVERWEIGHT
AB BACKGROUND: The Authors sought to evaluate current prevalence of mental disorders in patients affected by metabolic syndrome compared with patients affected by central obesity alone. METHODS: 186 (63.5%) patients affected by central obesity and 107 (36.5%) affected by metabolic syndrome according to ICF criteria were interviewed by means of SCID I. RESULTS: Axis I current prevalence was respectively 45.7% and 44.9% among patients with central obesity and patients with metabolic syndrome, differences which were not significant. No statistically significant differences were found between groups as far as each single axis I diagnostic category was concerned. Moreover, current prevalence of any axis I, anxiety and mood disorders were independent of the number of components of metabolic syndrome. CONCLUSION: metabolic syndrome is associated to an higher risk for current mental disorders, which seems to be mainly due to the strong association of central obesity to psychopathology. (Eat. Weight Disord 17: e259-e266, 2012). (c) 2012, Editrice Kurtis
C1 [Carpiniello, B.; Pinna, F.] Univ Cagliari, Dept Publ Hlth Clin & Mol Med, Sect Psychiat, I-09127 Cagliari, Italy.
   [Carpiniello, B.; Pinna, F.] Univ Cagliari, Psychiat Clin, I-09127 Cagliari, Italy.
   [Velluzzi, F.; Loviselli, A.] Univ Cagliari, Ctr Diag & Treatment Obes, Hosp Policlin, I-09127 Cagliari, Italy.
C3 University of Cagliari; University of Cagliari; University of Cagliari
RP Carpiniello, B (corresponding author), Univ Cagliari, Dept Publ Hlth Clin & Mol Med, Sect Psychiat, Via Liguria 13, I-09127 Cagliari, Italy.
EM bcarpini@iol.it
RI Pinna, Federica/LRU-3388-2024
OI Pinna, Federica/0000-0002-3108-9509
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NR 39
TC 14
Z9 14
U1 0
U2 13
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1124-4909
EI 1590-1262
J9 EAT WEIGHT DISORD-ST
JI Eat. Weight Disord.-Stud. Anorex.
PD DEC
PY 2012
VL 17
IS 4
BP E259
EP E266
DI 10.3275/8809
PG 8
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychiatry
GA 098GG
UT WOS:000315534900005
PM 23299201
DA 2025-06-11
ER

PT J
AU Henderson, KN
   Killen, LG
   O'Neal, EK
   Waldman, HS
AF Henderson, Kaemmer N.
   Killen, Lauren G.
   O'Neal, Eric K.
   Waldman, Hunter S.
TI The Cardiometabolic Health Benefits of Sauna Exposure in Individuals
   with High-Stress Occupations. A Mechanistic Review
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Review
DE firefighters; police; military; oxidative stress; inflammation;
   performance
ID ACTIVATED PROTEIN-KINASE; C-REACTIVE PROTEIN; ISCHEMIC-HEART-DISEASE;
   CARDIOVASCULAR-DISEASE; PSYCHOLOGICAL STRESS; IMPROVES MARKERS; THERMAL
   THERAPY; LIPID PROFILE; FIREFIGHTERS; AMPK
AB Components of the metabolic syndrome (i.e., hypertension, insulin resistance, obesity, atherosclerosis) are a leading cause of death in the United States and result in low-grade chronic inflammation, excessive oxidative stress, and the eventual development of cardiometabolic diseases (CMD). High-stress occupations (HSO: firefighters, police, military personnel, first responders, etc.) increase the risk of developing CMD because they expose individuals to chronic and multiple stressors (i.e., sleep deprivation, poor nutrition habits, lack of physical activity, psychological stress). Interestingly, heat exposure and, more specifically, sauna bathing have been shown to improve multiple markers of CMD, potentially acting as hormetic stressors, at the cellular level and in the whole organism. Therefore, sauna bathing might be a practical and alternative intervention for disease prevention for individuals with HSO. The purpose of this review is to detail the mechanisms and pathways involved in the response to both acute and chronic sauna bathing and collectively present sauna bathing as a potential treatment, in addition to current standard of care, for mitigating CMD to both clinicians and individuals serving in HSO.
C1 [Henderson, Kaemmer N.; Killen, Lauren G.; O'Neal, Eric K.; Waldman, Hunter S.] Univ North Alabama, Dept Kinesiol, Human Performance Lab, Florence, AL 35632 USA.
RP Waldman, HS (corresponding author), Univ North Alabama, Dept Kinesiol, Human Performance Lab, Florence, AL 35632 USA.
EM khenderson2@una.edu; lkillen1@una.edu; eoneal1@una.edu;
   Hswaldman@una.edu
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NR 98
TC 10
Z9 11
U1 1
U2 15
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD FEB
PY 2021
VL 18
IS 3
AR 1105
DI 10.3390/ijerph18031105
PG 13
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA QD0BL
UT WOS:000615193500001
PM 33513711
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Esposito, K
   Maiorino, MI
   Bellastella, G
   Panagiotakos, DB
   Giugliano, D
AF Esposito, Katherine
   Maiorino, Maria Ida
   Bellastella, Giuseppe
   Panagiotakos, Demosthenes B.
   Giugliano, Dario
TI Mediterranean diet for type 2 diabetes: cardiometabolic benefits
SO ENDOCRINE
LA English
DT Article
DE Mediterranean diet; Cardiometabolic risk; Type 2 diabetes; Glycemic
   control; Cardiovascular events
ID CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; STYLE DIET; INFLAMMATORY
   MARKERS; HEALTHY-ADULTS; RISK-FACTORS; WEIGHT-LOSS; LIFE-STYLE;
   FOLLOW-UP; METAANALYSIS
AB Dietary patterns influence various cardiometabolic risk factors, including body weight, lipoprotein concentrations, and function, blood pressure, glucose-insulin homeostasis, oxidative stress, inflammation, and endothelial health. The Mediterranean diet can be described as a dietary pattern characterized by the high consumption of plant-based foods, olive oil as the main source of fat, low-to-moderate consumption of fish, dairy products and poultry, low consumption of red and processed meat, and low-to-moderate consumption of wine with meals. The American Diabetes Association and the American Heart Association recommend Mediterranean diet for improving glycemic control and cardiovascular risk factors in type 2 diabetes. Prospective studies show that higher adherence to the Mediterranean diet is associated with a 20-23 % reduced risk of developing type 2 diabetes, while the results of randomized controlled trials show that Mediterranean diet reduces glycosylated hemoglobin levels by 0.30-0.47 %, and is also associated with a 28-30 % reduced risk for cardiovascular events. The mechanisms by which Mediterranean diet produces its cardiometabolic benefits in type 2 diabetes are, for the most, anti-inflammatory and antioxidative: increased consumption of high-quality foods may cool down the activation of the innate immune system, by reducing the production of proinflammatory cytokines while increasing that of anti-inflammatory cytokines. This may favor the generation of an anti-inflammatory milieu, which in turn may improve insulin sensitivity in the peripheral tissues and endothelial function at the vascular level and ultimately act as a barrier to the metabolic syndrome, type 2 diabetes and development of atherosclerosis.
C1 [Esposito, Katherine] Univ Naples 2, Dept Clin & Expt Med, Naples, Italy.
   [Maiorino, Maria Ida; Bellastella, Giuseppe; Giugliano, Dario] Univ Naples 2, Dept Med Surg Neurol Metab & Geriatr Sci, Naples, Italy.
   [Panagiotakos, Demosthenes B.] Harokopio Univ, Dept Nutr & Dietet, Athens, Greece.
C3 Universita della Campania Vanvitelli; Universita della Campania
   Vanvitelli; Harokopio University Athens
RP Esposito, K (corresponding author), Univ Naples 2, Dept Clin & Expt Med, Naples, Italy.
EM katherine.esposito@unina2.it
RI Panagiotakos, Demosthenes/K-8294-2019; Esposito,
   Katherine/AHE-2564-2022; Maiorino, Maria Ida/AHE-9986-2022; Maiorino,
   Maria Ida/K-3264-2016
OI Maiorino, Maria Ida/0000-0003-4659-7546; Giugliano,
   Dario/0000-0002-9377-873X
FU Associazione Salute con Stile
FX This work was supported in part by the "Associazione Salute con Stile".
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NR 43
TC 81
Z9 88
U1 2
U2 74
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1355-008X
EI 1559-0100
J9 ENDOCRINE
JI Endocrine
PD APR
PY 2017
VL 56
IS 1
BP 27
EP 32
DI 10.1007/s12020-016-1018-2
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA ER6WC
UT WOS:000398948900006
PM 27395419
DA 2025-06-11
ER

PT J
AU Bharathi, A
   Kar, SS
   Satheesh, S
   Sahoo, JP
AF Bharathi, Arivarasan
   Kar, Sitanshu Sekhar
   Satheesh, Santhosh
   Sahoo, Jaya Prakash
TI Metabolic Syndrome and Its Associated Factors Among Faculty Members in a
   Tertiary Care Teaching Hospital, Puducherry: A Cross-Sectional
   Analytical Study
SO METABOLIC SYNDROME AND RELATED DISORDERS
LA English
DT Article
DE metabolic syndrome; obesity; stress; sleep; Health Personnel;
   cardiometabolic risk factors
ID PHYSICIANS HEALTH; RISK-FACTORS; PREVALENCE; DETERMINANTS; POPULATION;
   BURNOUT; STRESS; INDIA; WOMEN; URBAN
AB Background: Settings-based approach has received lot of attention under WHO renewed strategy of health promotion. It advocates regular screening/health check-ups of employees to maintain a healthy workplace. This study aimed to assess prevalence of metabolic syndrome (MetS) among faculty members and its association with selected sociodemographic, behavioral and biochemical parameters, and to determine the 10-year fatal or nonfatal cardiovascular risk using WHO-ISH risk chart.Methodology: A cross-sectional study was conducted among 252 teaching faculty members using standardized international protocols to measure behavioral risk factors (smoking, alcohol consumption, diet pattern, physical activity, sleep, and stress), physical characteristics (weight, height, waist and hip circumferences, and blood pressure), and biochemical parameters (fasting glucose and lipid profile). Risk factor profiling was done using WHO/ISH risk prediction chart.Results: Among 252 participants (males: 172 and females: 80), 58 (24.1%) were with MetS. Prevalence was higher in males (24.6%) than females (22.6%). The younger doctors (<= 40 years) had lesser prevalence of MetS compared with the elderly (>40 years) doctors (20.3% vs. 26%). Age and diet pattern were found to be independently associated with MetS. The risk of having a cardiovascular event in 10 years was <5% (low risk) for 87.5% of study participants.Conclusion: Although we included doctors who are probably the most health-conscious population, we have found that one in four have a chance of having MetS. There is a need for periodic screening program and lifestyle modification strategies to control the burden of MetS among doctors.
C1 [Bharathi, Arivarasan; Kar, Sitanshu Sekhar] JIPMER, Dept Prevent & Social Med, Pondicherry, India.
   [Satheesh, Santhosh] JIPMER, Dept Cardiol, Pondicherry, India.
   [Sahoo, Jaya Prakash] JIPMER, Dept Endocrinol, Pondicherry, India.
   [Kar, Sitanshu Sekhar] JIPMER, Dept Prevent & Social Med, Pondicherry 605006, India.
C3 Jawaharlal Institute of Postgraduate Medical Education & Research;
   Jawaharlal Institute of Postgraduate Medical Education & Research;
   Jawaharlal Institute of Postgraduate Medical Education & Research;
   Jawaharlal Institute of Postgraduate Medical Education & Research
RP Kar, SS (corresponding author), JIPMER, Dept Prevent & Social Med, Pondicherry 605006, India.
EM drsitanshukar@gmail.com
RI Sahoo, Jayaprakash/HHZ-2657-2022; Kar, Sitanshu Sekhar/E-6031-2011
OI Kar, Sitanshu Sekhar/0000-0001-7122-523X
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NR 47
TC 0
Z9 0
U1 0
U2 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-4196
EI 1557-8518
J9 METAB SYNDR RELAT D
JI Metab. Syndr. Relat. Disord.
PD AUG
PY 2022
VL 20
IS 6
BP 336
EP 343
DI 10.1089/met.2021.0152
EA APR 2022
PG 8
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA S6IJ8
UT WOS:000789136000001
PM 35426739
DA 2025-06-11
ER

PT J
AU Fries, GR
   Zamzow, MJ
   Andrews, T
   Pink, O
   Scaini, G
   Quevedo, J
AF Fries, Gabriel R.
   Zamzow, Madeline J.
   Andrews, Taylor
   Pink, Omar
   Scaini, Giselli
   Quevedo, Joao
TI Accelerated aging in bipolar disorder: A comprehensive review of
   molecular findings and their clinical implications
SO NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
LA English
DT Review
DE Bipolar disorder; Mania; Depression; Aging; Telomere length; DNA
   methylation; Epigenetics; mtDNA; Oxidative stress; Inflammation
ID LEUKOCYTE TELOMERE LENGTH; DNA COPY NUMBER; ENVIRONMENTAL RISK-FACTORS;
   BODY-MASS INDEX; OXIDATIVE STRESS; MOOD DISORDERS; SYSTEMIC
   INFLAMMATION; UPDATED METAANALYSIS; METABOLIC SYNDROME; PREFRONTAL
   CORTEX
AB Bipolar disorder (BD) has been associated with clinical signs of accelerated aging, which potentially underlies its association with several age-related medical conditions, such as hypertension, metabolic imbalances, dementia, and cancer. This paper aims to comprehensively review evidence of biological aging in BD and explore findings and controversies related to common biological clocks in patients, including telomere length, DNA methylation, mitochondrial DNA copy number, inflammation, and oxidative stress. Our results suggest a complex interplay between biological markers and a potential key role of environmental factors, such as childhood trauma and psychological stress, in determining premature aging in patients. Moreover, given its multifactorial nature, our summary evidences the need for further studies incorporating clinical evidence with biomarkers of accelerated aging in BD. Results of this review strongly suggest BD as an accelerated aging disease seen in both clinical and molecular aspects. Understanding the pathophysiology of aging in BD may ultimately lead to identification of pathways that can be targeted for prevention of premature aging in patients and early onset of aging-related conditions.
C1 [Fries, Gabriel R.; Zamzow, Madeline J.; Andrews, Taylor; Pink, Omar; Scaini, Giselli; Quevedo, Joao] Univ Texas Hlth Sci Ctr Houston, Louis A Faillace MD Faillace Dept Psychiat & Beha, Translat Psychiat Program, 1941 East Rd, Houston, TX 77054 USA.
   [Fries, Gabriel R.] Univ Texas Hlth Sci Ctr Houston, Sch Biomed Informat, Ctr Precis Hlth, 7000 Fannin St, Houston, TX 77030 USA.
   [Fries, Gabriel R.; Quevedo, Joao] Univ Texas MD Anderson Canc Ctr, UTHlth Grad Sch Biomed Sci, Neurosci Grad Program, Houston, TX 77030 USA.
   [Quevedo, Joao] Univ Southern Santa Catarina UNESC, Grad Program Hlth Sci, Translat Psychiat Lab, Criciuma, SC, Brazil.
   Univ Texas Hlth Sci Ctr Houston, Faillace Dept Psychiat & Behav Sci, Ctr Excellence Mood Disorders, 1941 East Rd, Houston, TX 77054 USA.
C3 University of Texas System; University of Texas Health Science Center
   Houston; University of Texas System; University of Texas Health Science
   Center Houston; University of Texas System; UTMD Anderson Cancer Center;
   Universidade do Sul de Santa Catarina; University of Texas System;
   University of Texas Health Science Center Houston
RP Fries, GR (corresponding author), 1941 East Rd,Suite 3142, Houston, TX 77054 USA.
EM Gabriel.R.Fries@uth.tmc.edu
RI Scaini, Giselli/AAX-4437-2020; Fries, Gabriel R/P-8810-2014; de Quevedo,
   Joao Luciano/E-5491-2013; Scaini, Giselli/G-1378-2014
OI Fries, Gabriel R/0000-0002-5468-2612; Andrews,
   Taylor/0000-0003-3363-1549; de Quevedo, Joao
   Luciano/0000-0003-3114-6611; Scaini, Giselli/0000-0002-9880-0887
FU UTHealth Consortium on Aging, The University of Texas Houston Retiree
   Organization (UTHRO); University of Texas Health Science Center at
   Houston (UTHealth) - Center of Excellence on Mood Disorders (USA); Pat
   Rutherford Jr.; John S. Dunn Foundation; Anne and Don Fizer Foundation
   Endowment for Depression Research - Conselho Nacional de Desenvolvimento
   Cientifico e Tecnologico (CNPq); Coordenacao de Aperfeicoamento de
   Pessoal de Nivel Superior (CAPES); Fundacao de Amparo a Pesquisa e
   Inovacao do Estado de Santa Catarina (FAPESC); Instituto Cerebro e
   Mente; University of Southern Santa Catarina (UNESC); UTHealth Center
   for Clinical and Translational Sciences (CCTS)
FX This study was supported in part by the UTHealth Consortium on Aging,
   The University of Texas Houston Retiree Organization (UTHRO), and the
   Louis A. Faillace, MD Department of Psychiatry and Behavioral Sciences,
   The University of Texas Health Science Center at Houston (UTHealth).
   Translational Psychiatry Program (USA) is funded by the Louis A.
   Faillace, MD Department of Psychiatry and Behavioral Sciences, McGovern
   Medical School, UTHealth. Center of Excellence on Mood Disorders (USA)
   is funded by the Pat Rutherford Jr. Chair in Psychiatry, John S. Dunn
   Foundation and Anne and Don Fizer Foundation Endowment for Depression
   Research. Translational Psychiatry Laboratory (Brazil) is funded by
   grants from Conselho Nacional de Desenvolvimento Cientifico e
   Tecnologico (CNPq), Coordenacao de Aperfeicoamento de Pessoal de Nivel
   Superior (CAPES), Fundacao de Amparo a Pesquisa e Inovacao do Estado de
   Santa Catarina (FAPESC), Instituto Cerebro e Mente and University of
   Southern Santa Catarina (UNESC). GRF is supported by a career
   development grant from the UTHealth Center for Clinical and
   Translational Sciences (CCTS). JQ is a 1A CNPq Research Fellow. The
   authors declare no competing interests, and funding body had no role in
   the design of the study or decision to publish.
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NR 150
TC 65
Z9 68
U1 0
U2 10
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0149-7634
EI 1873-7528
J9 NEUROSCI BIOBEHAV R
JI Neurosci. Biobehav. Rev.
PD MAY
PY 2020
VL 112
BP 107
EP 116
DI 10.1016/j.neubiorev.2020.01.035
PG 10
WC Behavioral Sciences; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Behavioral Sciences; Neurosciences & Neurology
GA LK7AX
UT WOS:000531016100008
PM 32018037
DA 2025-06-11
ER

PT J
AU Loprinzi, PD
   Cardinal, BJ
AF Loprinzi, Paul D.
   Cardinal, Bradley J.
TI Interrelationships among physical activity, depression, homocysteine,
   and metabolic syndrome with special considerations by sex
SO PREVENTIVE MEDICINE
LA English
DT Article
DE Accelerometry; Chronic disease; Epidemiology; Exercise; Population
ID ENDOTHELIUM-DEPENDENT VASODILATION; PLASMA TOTAL HOMOCYSTEINE; PROTEIN-C
   ACTIVATION; 3RD NATIONAL-HEALTH; CARDIOVASCULAR-DISEASE;
   VASCULAR-DISEASE; SELF-EFFICACY; YOUNG-ADULTS; RISK-FACTOR; EXERCISE
AB Objective. Examine the interrelationships among physical activity, depression, homocysteine and metabolic syndrome, and to examine the association between physical activity and the simultaneous presence of metabolic syndrome, depression, and high homocysteine.
   Methods. Data from the 2005-2006 National Health and Nutrition Examination Survey were used. 1146 participants were included in the analyses. Physical activity was objectively measured using accelerometry.
   Results. With respect to the association between physical activity and the simultaneous presence of these three co-morbidities, women, compared to men, had a greater strength of association. For women, compared to those participants not having metabolic syndrome or at least mild depression or high homocysteine (reference groups), the odds ratio values for participants with 1) only depression, 2) only metabolic syndrome, 3) only high homocysteine, 4) metabolic syndrome and mild depression, and 5) metabolic syndrome, mild depression and high homocysteine, respectively, were 0.74 (95% confidence interval: 0.57-0.96, 0.77 (95% confidence interval: 0.61-0.97), 1.08 (95% confidence interval: 0.66-1.76), 0.43 (95% confidence interval: 0.32-0.58), and 0.15 (95% confidence interval: 0.05-0.44), respectively.
   Conclusion. Promotion of physical activity in the adult population, especially among women, who were found to be less moderately- to vigorously-physically active than their male counterparts, may play an important role in reducing these deleterious conditions. (C) 2012 Elsevier Inc. All rights reserved.
C1 [Loprinzi, Paul D.] Bellarmine Univ, Dept Exercise Sci, Donna & Allan Lansing Sch Nursing & Hlth Sci, Louisville, KY 40205 USA.
   [Cardinal, Bradley J.] Oregon State Univ, Coll Publ Hlth & Human Sci, Sch Biol & Populat Hlth Sci, Program Exercise & Sport Sci, Corvallis, OR 97331 USA.
C3 Bellarmine University; Oregon State University
RP Loprinzi, PD (corresponding author), Bellarmine Univ, Dept Exercise Sci, Donna & Allan Lansing Sch Nursing & Hlth Sci, Louisville, KY 40205 USA.
EM ploprinzi@bellarmine.edu; Brad.Cardinal@oregonstate.edu
RI Cardinal, Bradley/AAP-5795-2021
CR [Anonymous], NHANES SAMPL DES
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PI SAN DIEGO
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VL 54
IS 6
BP 388
EP 392
DI 10.1016/j.ypmed.2012.03.016
PG 5
WC Public, Environmental & Occupational Health; Medicine, General &
   Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; General & Internal Medicine
GA 960HP
UT WOS:000305378900003
PM 22486943
DA 2025-06-11
ER

PT J
AU Bove, M
   Carnevali, L
   Cicero, AFG
   Grandi, E
   Gaddoni, M
   Noera, G
   Gaddi, AV
AF Bove, Marilisa
   Carnevali, Lucio
   Cicero, Arrigo F. G.
   Grandi, Elisa
   Gaddoni, Morena
   Noera, Giorgio
   Gaddi, Antonio V.
CA Massa Lombarda Project Team
TI Psychosocial factors and metabolic parameters: Is there any association
   in elderly people? The Massa Lombarda Project
SO AGING & MENTAL HEALTH
LA English
DT Article
DE depression; mental stress; metabolic syndrome; uric acid; triglycerides
ID SERUM URIC-ACID; PERCEIVED STRESS QUESTIONNAIRE; MAJOR DEPRESSIVE
   DISORDER; CARDIOVASCULAR-DISEASE; OXIDATIVE STRESS; RISK-FACTORS;
   EPIDEMIOLOGY; SYMPTOMS; MEN
AB Objective: Several studies claim that psychophysical stress and depression contribute significantly to cardiovascular disease (CVD) development. The aim of our research is to discover and analyse a possible relationship between two psychosocial disorders (depression and perceived mental stress) and traditional cardiovascular risk markers. Methods: We selected 106 subjects (58 males and 48 females), mean age 79.5 +/- 3.8-years old, from the Massa Lombarda Project, an epidemiological study, including 7000 north Italian adult subjects. We carried out anamnesis, clinical and blood tests. Then, we administered the Perceived Stress Questionnaire (PSQ range score 0-1) and the Self-Rating Depression Scale (SRDS range score 50-70 Z), as validated instruments for depression and stress evaluation, which focus on the individual's subjective perception and emotional response. Statistical descriptive and inferential analyses of data collected were performed. Results: The multiple linear regression analysis showed a negative correlation between PSQ index score and uric acid, low-density lipoprotein cholesterol (LDL-c), body mass index (BMI), systolic and diastolic blood pressure values, a positive and statistically significant correlation between PSQ index score and triglycerides (p 0.05). We found an inverse relationship between Zung SRDS score and LDL-c, uric acid, glucose waist circumference values, this correlation was significant only for uric acid (p 0.01). Besides, a positive and significant correlation between Zung SRDS and triglycerides (p 0.05) was observed. Conclusion: We suppose that psycho-emotional stress and depression disorder, often diagnosed in elderly people, may influence different metabolic parameters (triglycerides, uric acid and BMI) that are involved in the complex process of metabolic syndrome.
C1 [Bove, Marilisa; Carnevali, Lucio; Cicero, Arrigo F. G.; Grandi, Elisa; Gaddi, Antonio V.] Univ Bologna, St Orsola Malpighi Hosp, Dept Aging & Kidney Dis, GC Descovich Atherosclerosis & Metab Dis Res Unit, I-40138 Bologna, Italy.
   [Gaddoni, Morena; Noera, Giorgio] Dept Cardiac Surg, I-48010 Cotignola, Ra, Italy.
C3 University of Bologna; IRCCS Azienda Ospedaliero-Universitaria di
   Bologna
RP Bove, M (corresponding author), Univ Bologna, St Orsola Malpighi Hosp, Dept Aging & Kidney Dis, GC Descovich Atherosclerosis & Metab Dis Res Unit, Via Massarenti 9, I-40138 Bologna, Italy.
EM marilisa.bove@aosp.bo.it
RI Grandi, Elisa/HLQ-5882-2023; Carnevali, Lucio/B-2335-2010; Cicero,
   Arrigo/H-8244-2019
OI Noera, Giorgio/0000-0002-2123-9964; Grandi, Elisa/0000-0003-3867-6228;
   Cicero, Arrigo Francesco Giuseppe/0000-0002-4367-3884
FU NIA NIH HHS [R01 AG019605, P30 AG028716] Funding Source: Medline
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NR 35
TC 31
Z9 34
U1 1
U2 15
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 1360-7863
EI 1364-6915
J9 AGING MENT HEALTH
JI Aging Ment. Health
PY 2010
VL 14
IS 7
BP 801
EP 806
AR PII 924399607
DI 10.1080/13607861003713299
PG 6
WC Geriatrics & Gerontology; Gerontology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Psychiatry
GA 642QM
UT WOS:000281231000004
PM 20635238
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Mashele, N
   Malan, L
   van Rooyen, JM
   Harvey, BH
   Potgieter, JC
   Hamer, M
AF Mashele, Nyiko
   Malan, Leone
   van Rooyen, Johannes M.
   Harvey, Brian H.
   Potgieter, Johan C.
   Hamer, Mark
TI Depression, Cardiometabolic Function and Left Ventricular Hypertrophy in
   African Men and Women: The SABPA Study
SO CLINICAL AND EXPERIMENTAL HYPERTENSION
LA English
DT Article
DE depressive symptoms; cardiometabolic risk; left ventricular hypertrophy;
   Africans
ID METABOLIC SYNDROME; GENERAL-POPULATION; RISK; HYPERTENSION; SYMPTOMS;
   HEALTH; DISEASE; THUSA; HEART; PHQ-9
AB Depressive symptoms are associated with an increased risk for developing cardiovascular diseases, driven by its link to the metabolic syndrome (MetS). This phenomenon, however, still needs to be investigated in the African population. The aim of this study is to investigate the association between left ventricular hypertrophy (LVH) and MetS risk markers in a determined sample. The researchers stratified Black African men and women into with depressive symptoms (D) or without depressive symptoms (ND) group, based on the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition criteria score. Fasting MetS, chronic hyperglycemia (HbA1c), ambulatory blood pressure (BP) and Cornell product-LVH (CP-LVH) in ECG measures were obtained. Depressive symptoms were reported in 45.3% of the sample. Independent of depression status, African men and women revealed a pre-diabetic state (glycated hemoglobin >5.7%). CP-LVH was associated with decreased low high-density lipoprotein cholesterol in D African women. In D African men, systolic BP (P = .001) and HbA1c (P = .08) explained 64% and 31% of the variation in LVH, respectively. In conclusion, depressive symptoms in Black African women were associated with a measure of target end organ damage, CP-LVH, and this association was driven by a metabolic factor. In Black African men, independent of depressive symptoms, LVH, was driven by cardiometabolic factors, namely SBP and HbA1c.
C1 [Mashele, Nyiko; Malan, Leone; van Rooyen, Johannes M.] North West Univ, HART, Sch Physiol Nutr & Consumer Sci, ZA-2520 Potchefstroom, South Africa.
   [Harvey, Brian H.] North West Univ, Div Pharmacol, Sch Pharm, Unit Drug Res & Dev, ZA-2520 Potchefstroom, South Africa.
   [Potgieter, Johan C.] North West Univ, Sch Psychosocial Behav Sci, ZA-2520 Potchefstroom, South Africa.
   [Hamer, Mark] UCL, Dept Epidemiol & Publ Hlth, London, England.
C3 North West University - South Africa; North West University - South
   Africa; North West University - South Africa; University of London;
   University College London
RP Malan, L (corresponding author), North West Univ, HART, Sch Physiol Nutr & Consumer Sci, Potchefstroom Campus,Private Bag X6001,Corner Ho, ZA-2520 Potchefstroom, South Africa.
EM leone.malan@nwu.ac.za
RI Malan, Leone/Q-8187-2019; Hamer, Mark/C-1602-2008; Malan,
   Leone/D-7203-2014
OI Hamer, Mark/0000-0002-8726-7992; Malan, Leone/0000-0003-3187-2410;
   Harvey, Brian/0000-0002-9864-7894
FU HART (North-West University); National Research Foundation South Africa,
   Metabolic Syndrome Institute, France [UID 65607]
FX The SABPA study was carried out by a multidisciplinary team from the
   HART, North-West University. This work was supported by the HART
   (North-West University) and National Research Foundation South Africa
   (UID 65607), Metabolic Syndrome Institute, France. The authors report no
   conflicts of interest. The authors alone are responsible for the content
   and writing of the paper.
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NR 41
TC 8
Z9 9
U1 0
U2 1
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1064-1963
EI 1525-6006
J9 CLIN EXP HYPERTENS
JI Clin. Exp. Hypertens.
PY 2013
VL 35
IS 3
BP 213
EP 219
DI 10.3109/10641963.2012.721837
PG 7
WC Pharmacology & Pharmacy; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Pharmacology & Pharmacy; Cardiovascular System & Cardiology
GA 117MG
UT WOS:000316956900009
PM 22954159
DA 2025-06-11
ER

PT J
AU Prabhakar, AP
   Lopez-Candales, A
AF Prabhakar, Akruti Patel
   Lopez-Candales, Angel
TI Calcific aortic valve disease and cardiometabolic triggers: an
   explanation behind progression of aortic valvular disease and failure of
   medical therapy interventions
SO POSTGRADUATE MEDICINE
LA English
DT Review
DE Aortic stenosis; metabolic syndrome; obesity; hypertension; morbidity;
   mortality
ID METABOLIC SYNDROME; ENDOTHELIAL-CELLS; IN-VIVO; OXIDIZED PHOSPHOLIPIDS;
   MECHANICAL-PROPERTIES; PSYCHOLOGICAL STRESS; EARLY LESION; STENOSIS;
   HEART; ASSOCIATION
AB Calcific aortic valve disease (CAVD), a nonrheumatic stenosis of the trileaflet aortic valve, is a complex, multifaceted cardiovascular condition involving a widespread inflammatory process and an analogous atheromatous process affecting the arteries. It is currently the most encountered valvular abnormality in cardiology. Although distinctive abnormal mechanical forces are at the core propelling a responsive mechanosensitive feedback cascade, implicated in both initiation and perpetuation of CAVD; we propose a conundrum of metabolic abnormalities including hypertension, elevated fasting blood sugar, decreased high-density lipoprotein, hypertriglyceridemia, and abdominal obesity as perpetuators of this process. Furthermore, we suggest CAVD as a cardio metabolic disorder. New perspectives as well as which pathways we believe are critically involved and ideas for early intervention are discussed.
C1 [Prabhakar, Akruti Patel] Univ Louisville, Dept Cardiovasc Med, Louisville, KY USA.
   [Lopez-Candales, Angel] Dayton VA Med Ctr, Wright State Boonshoft Sch Med, Cardiol Sect, Dayton, OH 45428 USA.
C3 University of Louisville; University System of Ohio; Wright State
   University Dayton
RP Lopez-Candales, A (corresponding author), Dayton VA Med Ctr, Wright State Boonshoft Sch Med, Cardiol, 4100 Third St, Dayton, OH 45428 USA.
EM angel.lopez-candales@va.gov
OI Prabhakar, Akruti/0009-0004-2172-4259
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NR 84
TC 0
Z9 0
U1 1
U2 2
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0032-5481
EI 1941-9260
J9 POSTGRAD MED
JI Postgrad. Med.
PD NOV 16
PY 2024
VL 136
IS 8
BP 810
EP 818
DI 10.1080/00325481.2024.2406740
EA SEP 2024
PG 9
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA M7I2O
UT WOS:001327443200001
PM 39297302
DA 2025-06-11
ER

PT J
AU Xiao, JL
   Lim, LKE
   Ng, CH
   Tan, DJH
   Lim, WH
   Ho, CSH
   Tan, EXX
   Sanyal, AJ
   Muthiah, MD
AF Xiao, Jieling
   Lim, Lincoln Kai En
   Ng, Cheng Han
   Tan, Darren Jun Hao
   Lim, Wen Hui
   Ho, Cyrus S. H.
   Tan, Eunice Xiang Xuan
   Sanyal, Arun J.
   Muthiah, Mark D.
TI Is Fatty Liver Associated With Depression? A Meta-Analysis and
   Systematic Review on the Prevalence, Risk Factors, and Outcomes of
   Depression and Non-alcoholic Fatty Liver Disease
SO FRONTIERS IN MEDICINE
LA English
DT Review
DE mood disorder; metabolic disease; fatty liver; evidence-based practice;
   mental health
ID Y GASTRIC BYPASS; METABOLIC SYNDROME; BARIATRIC SURGERY; ANXIETY;
   HEALTH; DISORDER; OBESITY; ANTIDEPRESSANTS; INFLAMMATION; CONFIDENCE
AB Background and Aims: Both non-alcoholic fatty liver disease (NAFLD) and depression have a high global prevalence which is projected to increase further. While studies exploring the association have been done, there are conflicting data. This study aims to assess the prevalence and association between depression and NAFLD. Methods: Medline and Embase were searched from inception to March 3, 2020. Meta-analysis of proportions using the generalized linear mix model was conducted to analyze the pooled prevalence of depression in NAFLD patients. Risk factors for depression in NAFLD patients were evaluated in conventional pairwise meta-analysis. Results: Ten studies involving 2,041,752 NAFLD patients were included. Pooled prevalence of depression was 18.21% (CI: 11.12-28.38%) in patients with NAFLD and 40.68% (CI: 25.11-58.37%) in patients with non-alcoholic steatohepatitis (NASH). NAFLD resulted in significantly higher risk of development of depression (OR: 1.29, CI: 1.02-1.64, p = 0.03). NASH patients had a significantly higher risk of depression compared with NAFLD patients (RR: 2.83, CI: 2.41-3.32, p < 0.001). Diabetes, body mass index (BMI), female sex, smoking, and history of pulmonary disease were significant risk factors for depression in NAFLD patients. Conclusion: This study demonstrated a high prevalence of depression in NAFLD patients and a significant association between both conditions. Furthermore, patients with NASH had a significantly higher risk of depression compared with those with NAFLD. Diabetes, BMI, history of lung disease or smoking, and female gender were significant risk factors. Further studies investigating the pathophysiological mechanism underlying depression and NAFLD are needed.
C1 [Xiao, Jieling; Lim, Lincoln Kai En; Ng, Cheng Han; Tan, Darren Jun Hao; Lim, Wen Hui; Ho, Cyrus S. H.; Tan, Eunice Xiang Xuan; Muthiah, Mark D.] Natl Univ Singapore, Yong Loo Lin Sch Med, Singapore, Singapore.
   [Ho, Cyrus S. H.] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Psychol Med, Singapore, Singapore.
   [Tan, Eunice Xiang Xuan; Muthiah, Mark D.] Natl Univ Hlth Syst, Natl Univ Ctr Organ Transplantat, Singapore, Singapore.
   [Tan, Eunice Xiang Xuan; Muthiah, Mark D.] Natl Univ Singapore Hosp, Dept Med, Div Gastroenterol & Hepatol, Singapore, Singapore.
   [Sanyal, Arun J.] Virginia Commonwealth Univ, Dept Internal Med, Div Gastroenterol Hepatol & Nutr, Richmond, VA USA.
C3 National University of Singapore; National University of Singapore;
   National University of Singapore; National University of Singapore;
   Virginia Commonwealth University
RP Ng, CH; Muthiah, MD (corresponding author), Natl Univ Singapore, Yong Loo Lin Sch Med, Singapore, Singapore.; Muthiah, MD (corresponding author), Natl Univ Hlth Syst, Natl Univ Ctr Organ Transplantat, Singapore, Singapore.; Muthiah, MD (corresponding author), Natl Univ Singapore Hosp, Dept Med, Div Gastroenterol & Hepatol, Singapore, Singapore.
EM chenhanng@gmail.com; mdcmdm@nus.edu.sg
RI Ho, Cyrus SH/AAN-9344-2020; Ng, Cheng Han/IWU-3648-2023
OI Tan, Eunice/0000-0002-3757-4986; Lim, Lincoln/0000-0002-5131-3109; Ho,
   Cyrus SH/0000-0002-7092-9566
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NR 70
TC 57
Z9 57
U1 0
U2 9
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 2296-858X
J9 FRONT MED-LAUSANNE
JI Front. Med.
PD JUN 30
PY 2021
VL 8
AR 691696
DI 10.3389/fmed.2021.691696
PG 9
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA TJ1FM
UT WOS:000673236600001
PM 34277666
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Happell, B
   Platania-Phung, C
   Scott, D
AF Happell, Brenda
   Platania-Phung, Chris
   Scott, David
TI Are Nurses in Mental Health Services Providing Physical Health Care for
   People with Serious Mental Illness? An Australian Perspective
SO ISSUES IN MENTAL HEALTH NURSING
LA English
DT Article
ID LIFE-STYLE INTERVENTION; SEXUAL HEALTH; METABOLIC SYNDROME;
   CIGARETTE-SMOKING; CO-MORBIDITY; SCHIZOPHRENIA; BARRIERS; WEIGHT;
   DEPRESSION; DISORDERS
AB People with serious mental illness are at high-risk for physical illnesses and premature death, and nurses can contribute to ensuring mental health services address these risks. There is very little research examining the role of nurses in mental health who provide physical health care. To identify the levels of participation in physical health care of people with serious mental illness (SMI), a national Internet-based survey of nurses working in mental health in Australia was conducted (n = 643). The survey included an adapted version of the Robson and Haddad Physical Health Attitude Scale. Data were analysed through comparison of frequencies, correlations, principal components analysis, and Mann-Whitney tests. Nurses reported regular physical health care in 12 of the 17 tasks presented to them. The three most common self-reported physical health care activities were inquiring about consumers' contact with GPs, doing physical assessments, and providing information on drug use and lifestyle. Although some practices were less common (e.g., contraceptive advice) nurses who provided one type of care tended to do other types as well. In addition, credentialing in mental health nursing was associated with slightly more regular engagement in all practice domains except screening and assessments. Nurses in mental health in Australia may be engaged in improving physical health of consumers with SMI more than is assumed.
C1 Cent Queensland Univ, Inst Hlth & Social Sci Res, Ctr Mental Hlth Nursing Innovat, Rockhampton, Qld 4702, Australia.
   Cent Queensland Univ, Sch Nursing & Midwifery, Rockhampton, Qld 4702, Australia.
C3 Central Queensland University; Central Queensland University
RP Happell, B (corresponding author), CQ Univ Australia, Inst Hlth & Social Sci Res, Rockhampton, Qld 4701, Australia.
EM b.happell@cqu.edu.au
RI Scott, David/AAE-5031-2021; Happell, Brenda/HSI-0570-2023
OI Scott, David/0000-0001-5226-1972; Happell, Brenda/0000-0002-7293-6583
CR Australian College of Mental Health Nurses, 2012, CRED PRACT PROGR
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NR 46
TC 22
Z9 22
U1 0
U2 10
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 0161-2840
EI 1096-4673
J9 ISSUES MENT HEALTH N
JI Issues Ment. Health Nurs.
PD MAR
PY 2013
VL 34
IS 3
BP 198
EP 207
DI 10.3109/01612840.2012.733907
PG 10
WC Nursing; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Psychiatry
GA V38TP
UT WOS:000209366000009
PM 23477441
DA 2025-06-11
ER

PT J
AU Warner, JO
AF Warner, John O.
TI Artificial food additives: hazardous to long-term health?
SO ARCHIVES OF DISEASE IN CHILDHOOD
LA English
DT Review
DE Obesity; Child Health; Mental health; Toxicology
ID HISTAMINE-RELEASE; DOUBLE-BLIND; HYPERACTIVITY; CHILDREN
AB Many additives, some of which have no nutritional value, can be legally used in processed foods. They intensify colour, thicken, increase shelf life and enhance flavour. Regulatory authorities issue approvals as safe within acceptable quantitative limits. Ultra-processed foods (UPFs) contain combinations of all these additives and are particularly attractive to children.
   Many publications suggest that artificial colourants, benzoate preservatives, non-caloric sweeteners, emulsifiers and their degradation derivatives have adverse effects by increasing risks of mental health disorders, attention deficit hyperactivity disorder, cardiovascular disease, metabolic syndrome and potential carcinogenic effects.
   A systematic review has established that artificial azo dye food colourants (AFCs) and sodium benzoate preservative cause disturbed behaviour in children. AFCs and benzoates in animal models have neurotoxic properties through gut microbial generation of toxic metabolites. Observational studies show associations between high emulsifier intake and cardiovascular disease. Animal models and in vitro studies have highlighted neurotoxic, cytotoxic, genotoxic and carcinogenic effects. High intake of non-caloric sweeteners has been linked to cardiovascular disease and depression in adults and is linked to childhood obesity.
   Little research has focused on children who are the largest consumers of UPFs. Potentially, they are a ticking time bomb for adult obesity, metabolic syndrome, cardiovascular diseases, mental health disorders and cancers. Based on risk/benefit analysis, azo dye AFCs should be banned. Benzoates, emulsifiers and sweeteners require assessment of quantitative limits and cumulative effects of combinations. Consumers purchasing UPFs require information through ingredient health warnings and recommendations to use natural unprocessed foods which have well-described health-promoting properties.
C1 [Warner, John O.] Imperial Coll London, Natl Heart & Lung Inst, Inflammat Repair & Dev Sect, Fac Med, London, England.
C3 Imperial College London
RP Warner, JO (corresponding author), Imperial Coll London, Natl Heart & Lung Inst, Inflammat Repair & Dev Sect, Fac Med, London, England.
EM j.o.warner@imperial.ac.uk
RI Warner, John/AAF-9587-2020
OI Warner, John/0000-0001-7123-6369
FU Food Standards Agency (UK)
FX While I had no funding to produce this manuscript, the challenge studies
   performed by my group and reported in the paper were funded by grants
   from the Food Standards Agency (UK).
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NR 29
TC 10
Z9 10
U1 37
U2 80
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 0003-9888
EI 1468-2044
J9 ARCH DIS CHILD
JI Arch. Dis. Child.
PD NOV 1
PY 2024
VL 109
IS 11
BP 882
EP 885
DI 10.1136/archdischild-2023-326565
EA FEB 2024
PG 4
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA M8M6O
UT WOS:001181903200001
PM 38423749
DA 2025-06-11
ER

PT J
AU Ikeda, A
   Steptoe, A
   Brunner, EJ
   Maruyama, K
   Tomooka, K
   Kato, T
   Miyoshi, N
   Nishioka, S
   Saito, I
   Tanigawa, T
AF Ikeda, Ai
   Steptoe, Andrew
   Brunner, Eric J.
   Maruyama, Koutatsu
   Tomooka, Kiyohide
   Kato, Tadahiro
   Miyoshi, Noriko
   Nishioka, Shinji
   Saito, Isao
   Tanigawa, Takeshi
TI Salivary Alpha-Amylase Activity in Relation to Cardiometabolic Status in
   Japanese Adults without History of Cardiovascular Disease
SO JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
LA English
DT Article
DE Salivary alpha-amylase activity; Glucose intolerance; Insulin
   resistance; Blood pressure
ID HEART-RATE-VARIABILITY; TYPE-2 DIABETES-MELLITUS; FASTING
   PLASMA-GLUCOSE; STRESS-INDUCED CHANGES; INSULIN-RESISTANCE;
   GENDER-DIFFERENCES; PSYCHOLOGICAL STRESS; SOCIOECONOMIC-STATUS;
   METABOLIC SYNDROME; SEX-DIFFERENCES
AB Aims: Stress is known to be a potential contributor to the development of diabetes and hypertension. However, the biological mechanisms underlying the association between cardiometabolic risk markers and the biological stress response have not yet been determined. Therefore, we examined salivary alpha-amylase and heart rate variability in relation to cardiometabolic status in a sample of healthy Japanese men and women.
   Methods: Participants (473 men and 1,029 women aged 30-84) underwent a 75 g oral glucose tolerance test after a 10-hr fast. The homeostasis model assessment index for insulin resistance was based on fasting and 2-hr postload glucose and insulin concentrations. Sitting blood pressure was measured twice after rest. A saliva sample was collected in the morning and salivary alpha-amylase was assayed. A 5-min heart rate variability recording was evaluated using time-domain indices of standard deviations of normal-to-normal intervals and root mean square of successive differences. Multivariate linear regression models were used to estimate associations between salivary alpha-amylase and each outcome measure.
   Results: Salivary alpha-amylase was associated with fasting glucose (beta = 0.008; 95% CI = 0.002, 0.014), 2-hr postload glucose (beta = 0.023; 95% CI = 0.004, 0.041), homeostasis model assessment index for insulin resistance (beta = 0.032; 95%CI = 0.000, 0.064), systolic (beta = 1.603; 95% CI = 0.479, 2.726) and diastolic (beta = 0.906; 95% CI = 0.212, 1.600) blood pressures among women. These associations remained significant after further adjustment for heart rate variability measures.
   Conclusions: The elevation of salivary alpha-amylase may reflect a dysfunction of the sympathetic nervous system associated with cardiometabolic abnormalities in women.
C1 [Ikeda, Ai; Tomooka, Kiyohide; Miyoshi, Noriko; Tanigawa, Takeshi] Juntendo Univ, Dept Publ Hlth, Grad Sch Med, Tokyo, Japan.
   [Ikeda, Ai; Steptoe, Andrew; Brunner, Eric J.] UCL, Fac Populat Hlth Sci, Dept Epidemiol & Publ Hlth, London, England.
   [Maruyama, Koutatsu; Nishioka, Shinji] Ehime Univ, Grad Sch Agr, Dept Biosci, Lab Community Hlth & Nutr,Special Course Food & H, Matsuyama, Ehime, Japan.
   [Kato, Tadahiro] Ehime Univ, Fac Educ, Ctr Educ & Educ Res, Matsuyama, Ehime, Japan.
   [Nishioka, Shinji] Ehime Dent Assoc, Matsuyama, Ehime, Japan.
   [Saito, Isao] Oita Univ, Fac Med, Dept Publ Hlth & Epidemiol, Yufu, Japan.
C3 Juntendo University; University of London; University College London;
   Ehime University; Ehime University; Oita University
RP Tanigawa, T (corresponding author), Juntendo Univ, Dept Publ Hlth, Grad Sch Med, Bunkyo Ku, 2-1-1 Hongo, Tokyo 1138421, Japan.
EM tataniga@juntendo.ac.jp
RI Brunner, Eric/H-2114-2011; Steptoe, Andrew/Y-2440-2019
OI Brunner, Eric/0000-0002-0595-4474
FU JSPS KAKENHI [JP16K09072, JP17KK0175, JP18H03056, JP18K10087,
   JP17K00881]; MRC [MR/R024227/1] Funding Source: UKRI
FX This study was supported by JSPS KAKENHI Grant Numbers; JP16K09072,
   JP17KK0175, JP18H03056, JP18K10087, JP17K00881.
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NR 52
TC 5
Z9 5
U1 0
U2 5
PU JAPAN ATHEROSCLEROSIS SOC
PI TOKYO
PA NICHINAI-KAIKAN B1, 3-28-8 HONGO BUNKYO-KU, TOKYO, 113-0033, JAPAN
SN 1340-3478
EI 1880-3873
J9 J ATHEROSCLER THROMB
JI J. Atheroscler. Thromb.
PY 2021
VL 28
IS 8
BP 852
EP 864
DI 10.5551/jat.53926
PG 13
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Cardiovascular System & Cardiology
GA TU1KO
UT WOS:000680798800009
PM 33041312
OA Green Published, gold
DA 2025-06-11
ER

EF﻿FN Clarivate Analytics Web of Science
VR 1.0
PT J
AU Alessi, MC
   Juhan-Vague, I
AF Alessi, Marie-Christine
   Juhan-Vague, Irene
TI Metabolic syndrome, haemostasis and thrombosis
SO THROMBOSIS AND HAEMOSTASIS
LA English
DT Review
DE haemostasis; metabolic syndrome; visceral obesity; platelet;
   coagulation; fibrinolysis; endothelial dysfunction
ID PLASMINOGEN-ACTIVATOR INHIBITOR-1; DEPENDENT PLATELET-AGGREGATION;
   NUTRITIONALLY INDUCED OBESITY; ADIPOSE-TISSUE DEVELOPMENT;
   CORONARY-ARTERY-DISEASE; FACTOR GENE-EXPRESSION; INSULIN-RESISTANCE;
   ENDOTHELIAL DYSFUNCTION; VENOUS THROMBOEMBOLISM; RISK-FACTORS
AB The metabolic syndrome (metS), a concurrence of abdominal fat, disturbed glucose and insulin metabolism, dyslipidemia, and hypertension has been strongly associated not only with subsequent development of type 2 diabetes but also with atherothrombosis. The physiopathology of this association is complex. The metS affects the thrombogenicity of circulating blood. Apart from its effect on platelets, a procoagulant and hypofibrinolytic state has been identified; mainly the result of the inflammatory state, dyslipidemia,and liver fat accumulation that accompany the MetS. Among haemostasis disturbances, the strong rise in the inhibitor of plasminogen activator type I plasma level is the most documented abnormality implicating the participation of the oxidative stress and inflammatory state developed during the metS. Endothelial dysfunction is also a central feature. Moreover, secretion products of fat tissues (adipokines) are now thought to have direct modulating effects on the vascular and the circulating cells. In support of these data, the metS, may predispose not only to atherosclerosis but also to venous thrombosis.
C1 [Alessi, Marie-Christine; Juhan-Vague, Irene] Univ Mediterranee, Hematol Lab, Fac Med, Inserm UMR 626, F-13385 Marseille, France.
C3 Aix-Marseille Universite; Institut National de la Sante et de la
   Recherche Medicale (Inserm)
RP Alessi, MC (corresponding author), Univ Mediterranee, Hematol Lab, Fac Med, Inserm UMR 626, 27 Bd Jean Moulin, F-13385 Marseille, France.
EM marie-christine.alessi@univmed.fr
RI ALESSI, Marie-christine/AAK-3582-2020
OI ALESSI, Marie-christine/0000-0003-3927-5792
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NR 102
TC 147
Z9 160
U1 1
U2 7
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0340-6245
EI 2567-689X
J9 THROMB HAEMOSTASIS
JI Thromb. Haemost.
PD JUN
PY 2008
VL 99
IS 6
BP 995
EP 1000
DI 10.1160/TH07-11-0682
PG 6
WC Hematology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Hematology; Cardiovascular System & Cardiology
GA 314SU
UT WOS:000256829900006
PM 18521499
DA 2025-06-11
ER

PT J
AU Gao, CH
   Gong, NY
   Chen, FT
   Hu, SR
   Zhou, QX
   Gao, X
AF Gao, Chunhao
   Gong, Nengyun
   Chen, Fangtian
   Hu, Shiran
   Zhou, Qingxin
   Gao, Xiang
TI The Effects of Astaxanthin on Metabolic Syndrome: A Comprehensive Review
SO MARINE DRUGS
LA English
DT Review
DE astaxanthin; metabolic syndrome; obesity; insulin resistance;
   dyslipidemia
ID DIET-INDUCED OBESITY; IMPROVES GLUCOSE-METABOLISM; REDUCES
   BLOOD-PRESSURE; RECEPTOR PPAR-ALPHA; INSULIN-RESISTANCE; OXIDATIVE
   STRESS; LIPID-METABOLISM; SKELETAL-MUSCLE; ADIPOSE-TISSUE; MICE
AB Metabolic syndrome (MS) represents a complex cluster of metabolic disorders primarily characterized by obesity, insulin resistance, hyperglycemia, dyslipidemia, hypertension, and hyperuricemia. Diet and functional ingredients play a pivotal role in seeking non-pharmacological strategies to prevent and ameliorate MS. Astaxanthin (AST), a carotenoid found in various marine organisms, exhibits exceptional antioxidant properties and holds great promise as a natural compound that improves MS. This article introduces the basic properties of AST, including its absorptance and metabolic pathways, along with various isomers. Most importantly, we comprehensively review the effects and mechanisms of AST on improving the primary components of MS. These mechanisms primarily involve regulating signal transduction, transport, or metabolic pathways within the body, as well as influencing intestinal microbiota and metabolites, thereby exerting positive effects on metabolism and inhibiting the occurrence of MS. This review emphasizes the potential efficacy of AST in managing MS. However, more studies are needed to confirm the clinical effect of AST on MS and reveal potential molecular mechanisms.
C1 [Gao, Chunhao; Gong, Nengyun; Hu, Shiran; Gao, Xiang] Qingdao Univ, Coll Life Sci, Qingdao 266071, Peoples R China.
   [Chen, Fangtian; Zhou, Qingxin] Rizhao Polytech, Shandong Engn Res Ctr Efficient Utilizat Technol M, Shandong Engn & Technol Res Ctr Marine Crustacean, Rizhao Key Lab Efficient Utilizat Marine Food Reso, Rizhao 276826, Peoples R China.
C3 Qingdao University; Rizhao Polytechnic
RP Gao, X (corresponding author), Qingdao Univ, Coll Life Sci, Qingdao 266071, Peoples R China.; Zhou, QX (corresponding author), Rizhao Polytech, Shandong Engn Res Ctr Efficient Utilizat Technol M, Shandong Engn & Technol Res Ctr Marine Crustacean, Rizhao Key Lab Efficient Utilizat Marine Food Reso, Rizhao 276826, Peoples R China.
EM gaoch0306@163.com; gny907@126.com; fangxitianjian@126.com;
   hushiran0131@163.com; sdzhouqingxin@126.com; gaoxiang@qdu.edu.cn
RI Gao, Xiang/AAM-6922-2021
OI Gao, Xiang/0000-0002-4674-0317
FU Natural Science Foundation of Shandong Province; Shandong Province
   Colleges and Universities "youth innovation technology plan" project
   [2019KJF014];  [ZR2024MC094]
FX This research was funded by the Natural Science Foundation of Shandong
   Province (ZR2024MC094) and the Shandong Province Colleges and
   Universities "youth innovation technology plan" project (2019KJF014).
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   Zhou QX, 2019, J SCI FOOD AGR, V99, P3662, DOI 10.1002/jsfa.9588
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NR 155
TC 1
Z9 1
U1 10
U2 10
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1660-3397
J9 MAR DRUGS
JI Mar. Drugs
PD JAN
PY 2025
VL 23
IS 1
AR 9
DI 10.3390/md23010009
PG 24
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA T3X1H
UT WOS:001404367000001
PM 39852511
OA gold
DA 2025-06-11
ER

PT J
AU Hasanpour-Segherlou, Z
   Butler, AA
   Candelario-Jalil, E
   Hoh, BL
AF Hasanpour-Segherlou, Zahra
   Butler, Andrew A.
   Candelario-Jalil, Eduardo
   Hoh, Brian L.
TI Role of the Unique Secreted Peptide Adropin in Various Physiological and
   Disease States
SO BIOMOLECULES
LA English
DT Review
DE adropin; endothelial cells; metabolic syndrome; cardiovascular disease;
   cerebrovascular disorders; subarachnoid hemorrhage
ID DELAYED CEREBRAL VASOSPASM; OBSTRUCTIVE SLEEP-APNEA; FLOW-MEDIATED
   DILATATION; BLOOD-BRAIN-BARRIER; SERUM ADROPIN; NITRIC-OXIDE;
   INSULIN-RESISTANCE; ENDOTHELIAL DYSFUNCTION; DIABETES-MELLITUS;
   OXIDATIVE STRESS
AB Adropin, a secreted peptide hormone identified in 2008, plays a significant role in regulating energy homeostasis, glucose metabolism, and lipid metabolism. Its expression is linked to dietary macronutrient intake and is influenced by metabolic syndrome, obesity, diabetes, and cardiovascular diseases. Emerging evidence suggests that adropin might be a biomarker for various conditions, including metabolic syndrome, coronary artery disease, and hypertensive disorders complicating pregnancy. In cerebrovascular diseases, adropin demonstrates protective effects by reducing blood-brain barrier permeability, brain edema, and infarct size while improving cognitive and sensorimotor functions in ischemic stroke models. The protective effects of adropin extend to preventing endothelial damage, promoting angiogenesis, and mitigating inflammation, making it a promising therapeutic target for cardiovascular and neurodegenerative diseases. This review provides a comprehensive overview of adropin's multifaceted roles in physiological and pathological conditions, as well as our recent work demonstrating adropin's role in subarachnoid hemorrhage-mediated neural injury and delayed cerebral infarction.
C1 [Hasanpour-Segherlou, Zahra; Hoh, Brian L.] Univ Florida, Coll Med, Dept Neurosurg, Gainesville, FL 32610 USA.
   [Butler, Andrew A.] St Louis Univ, Dept Pharmacol & Physiol Sci, St Louis, MO 63104 USA.
   [Candelario-Jalil, Eduardo] Univ Florida, Coll Med, Dept Neurosci, Gainesville, FL 32610 USA.
C3 State University System of Florida; University of Florida; Saint Louis
   University; State University System of Florida; University of Florida
RP Hoh, BL (corresponding author), Univ Florida, Coll Med, Dept Neurosurg, Gainesville, FL 32610 USA.
EM zahra.hasanpoursegherlou@neurosurgery.ufl.edu;
   andrew.butler@health.slu.edu; ecandelario@ufl.edu;
   brian.hoh@neurosurgery.ufl.edu
RI Candelario-Jalil, Eduardo/I-1139-2019
OI Candelario-Jalil, Eduardo/0000-0003-3631-1989
FU NIH [R01NS124620]; Eblen Research Endowment", "Christine Desmond Fund;
   James and Brigette Marino Family Professorship Endowment; St. George
   Family Fund
FX This research was funded by NIH, grant number "R01NS124620", "Eblen
   Research Endowment", "Christine Desmond Fund", "James and Brigette
   Marino Family Professorship Endowment", and "St. George Family Fund".
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NR 175
TC 1
Z9 1
U1 9
U2 9
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2218-273X
J9 BIOMOLECULES
JI Biomolecules
PD DEC
PY 2024
VL 14
IS 12
AR 1613
DI 10.3390/biom14121613
PG 19
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA Q8C8H
UT WOS:001386897200001
PM 39766320
OA gold
DA 2025-06-11
ER

PT J
AU Mutamba, AK
   He, XR
   Wang, T
AF Mutamba, Alpha Kalonda
   He, Xiaori
   Wang, Tao
TI Therapeutic advances in overcoming intrauterine growth restriction
   induced metabolic syndrome
SO FRONTIERS IN PEDIATRICS
LA English
DT Review
DE small gestational age (SGA); lipid metabolism; insulin resistance; type
   2 diabetes; intrauterine growth restriction
ID FOR-GESTATIONAL-AGE; NONALCOHOLIC FATTY LIVER; CATCH-UP GROWTH;
   INSULIN-RESISTANCE; FETAL-GROWTH; LIPID-METABOLISM; DEVELOPMENTAL
   ORIGINS; BIRTH-WEIGHT; FACTOR-I; ENDOCRINE PANCREAS
AB Intrauterine growth restriction (IUGR) remains a great public health challenge as it affects neonatal survival and influences their normal biological development and metabolism. Several clinical researches have revealed the occurrence of metabolic syndrome, such as insulin resistance, obesity, type 2 diabetes mellitus, oxidative stress, dyslipidemia, as direct results of IUGR. Therefore, it is essential to understand its underlying mechanism, impact and develop effective therapies. The purpose of this work is to review the current knowledge on IUGR induced metabolic syndrome and relevant therapies. Here in, we elaborate on the characteristics and causes of IUGR by pointing out recent research findings. Furthermore, we discuss the impact of IUGR on different organs of the body, followed by preclinical studies on IUGR using suitable animal models. Additionally, various metabolic disorders with their genetic implications, such as insulin resistance, type 2 diabetes mellitus, dyslipidemia, obesity are detailed. Finally, the current therapeutic options used in the treatment of IUGR are summarized with some prospective therapies highlighted.
C1 [Mutamba, Alpha Kalonda; He, Xiaori] Cent South Univ, Xiangya Hosp 2, Dept Pediat, Neonatol, Changsha, Peoples R China.
   [Wang, Tao] Cent South Univ, Inst Pediat, Lab Neonatal Dis, Changsha, Peoples R China.
C3 Central South University; Central South University
RP He, XR (corresponding author), Cent South Univ, Xiangya Hosp 2, Dept Pediat, Neonatol, Changsha, Peoples R China.; Wang, T (corresponding author), Cent South Univ, Inst Pediat, Lab Neonatal Dis, Changsha, Peoples R China.
EM hexiaori@csu.edu.cn; wangtao001@csu.edu.cn
FU National Natural Science Foundation of Hunan Province of the People's
   Republic of China [2020JJ4785, 2022JJ30848]; Changsha Municipal Natural
   Science Foundation of Hunan Province of the People's Republic of China
   [AU-YJY-B-LX-20-022]; Ausnutria Food and Nutrition Science Research
   Fund;  [kq2007077]
FX This work was supported by The National Natural Science Foundation of
   Hunan Province of the People's Republic of China (grant no. 2020JJ4785,
   2022JJ30848), Ausnutria Food and Nutrition Science Research Fund
   (AU-YJY-B-LX-20-022), and The Changsha Municipal Natural Science
   Foundation of Hunan Province of the People's Republic of China (grant
   no. kq2007077).
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NR 106
TC 6
Z9 6
U1 0
U2 10
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-2360
J9 FRONT PEDIATR
JI Front. Pediatr.
PD JAN 11
PY 2023
VL 10
AR 1040742
DI 10.3389/fped.2022.1040742
PG 9
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA 8F8VW
UT WOS:000919935100001
PM 36714657
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Stewart-Knox, BJ
AF Stewart-Knox, BJ
TI Psychological underpinnings of metabolic syndrome
SO PROCEEDINGS OF THE NUTRITION SOCIETY
LA English
DT Article; Proceedings Paper
CT Annual Meeting of the
   Nurtition-Society/British-Association-for-Parenteral-and-Enteral-Nutriti
   on
CY NOV 17-18, 2004
CL Telford, ENGLAND
SP Nutr Soc, British Assoc Parenteral & Enteral Nutr
DE metabolic syndrome; psychological; social; demographic; cultural
ID TIME PHYSICAL-ACTIVITY; INSULIN-RESISTANCE; WAIST CIRCUMFERENCE;
   WEIGHT-GAIN; CARDIORESPIRATORY FITNESS; SOCIOECONOMIC-FACTORS; ABDOMINAL
   OBESITY; VISCERAL OBESITY; YOUNG ADULTHOOD; NERVOUS-SYSTEM
AB Metabolic syndrome (MS) is more common among socio-economically disadvantaged individuals and is associated with certain risky lifestyle practices. MS also appears to be triggered by adverse social circumstances and chronic stress. The present paper reviews accumulating evidence to imply that individuals who have certain personality and behaviour traits are particularly predisposed to develop MS, and brings together theories that relate to possible psychological mechanisms underlying MS. It considers how such factors might interact causally to encourage the development of MS. As part of the EU-funded LIPGENE Integrated Project, multi-level modelling will be undertaken to explore potential pathways to MS, taking into consideration the interplay between a range of psycho-social, demographic, cultural and lifestyle factors thought to contribute to the development of MS. Data will be gathered for this purpose from a representative sample of > 50-year-olds living in Britain (n 1000) and Portugal (n 500). It is anticipated that this information will assist in the development and targetting of future intervention to prevent and treat MS in the normal population.
C1 Univ Ulster, No Ireland Ctr Food & Hlth, Coleraine BT52 1SA, Londonderry, North Ireland.
C3 Ulster University
RP Univ Ulster, No Ireland Ctr Food & Hlth, Coleraine BT52 1SA, Londonderry, North Ireland.
EM b.knox@ulster.ac.uk
OI Stewart-Knox, Barbara/0000-0002-6741-3657
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NR 84
TC 22
Z9 24
U1 1
U2 6
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0029-6651
EI 1475-2719
J9 P NUTR SOC
JI Proc. Nutr. Soc.
PD JUL
PY 2005
VL 64
IS 3
BP 363
EP 369
DI 10.1079/PNS2005444
PG 7
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI); Conference Proceedings Citation Index - Science (CPCI-S)
SC Nutrition & Dietetics
GA 949VM
UT WOS:000230816200014
PM 16048670
OA Bronze
DA 2025-06-11
ER

PT J
AU Salonen, P
   Arola, H
   Nygård, CH
   Huhtala, H
AF Salonen, P.
   Arola, H.
   Nygard, C. -H.
   Huhtala, H.
TI Associations of health, dietary and job-related factors, and mental
   problems with cardiovascular diseases in aging
SO JOURNAL OF NUTRITION HEALTH & AGING
LA English
DT Article
DE cardiovascular morbidity; hypertension; health factors; dietary factors;
   job-related factors; mental problems; aging employees
ID METABOLIC SYNDROME; NATIONAL-HEALTH; RISK-FACTORS; HYPERTENSION;
   MORTALITY; DEPRESSION; MORBIDITY; HEART
AB Background: While cardiovascular diseases are prevalent in aging population, associations between different factors and cardiovascular diseases are less studied or inconsistency still exists. Aim: To determine which factors measured at baseline predicted overall cardiovascular diseases and hypertension, and which factors were currently associated with these conditions. Methods: Based on a sample of aging and retired food industry employees (N = 100, mean age 62 years) associations of health, dietary and job-related factors and mental problems with overall cardiovascular morbidity and hypertension were assessed with independent samples t-test, X-2 test and binary logistic regression analyses. Data were derived from health examinations and self-completed questionnaires in 1989 and 2000. Results: Added medical findings, related to cardiovascular diseases, appeared as predictor of overall cardiovascular morbidity, while elevated blood pressure together with high systolic and diastolic pressure, dyslipidernia and elevated blood pressure together, added medical findings, and inability to enjoy daily activities predicted hypertension. According to our analyses most significant current associations with overall cardiovascular morbidity were feeling of weakness, dyspnoea, hopelessness about the future, cardiac arrhythmia, chronic mental stress and lower HDL cholesterol, and with hypertension metabolic syndrome, lower HDL cholesterol, hopelessness about the future and muscular fatigue on exertion. Conclusions: Health factors were most important predictors of hypertension during a long-term period, while health factors together with mental problems had significant current associations with overall cardiovascular morbidity including hypertension.
C1 Univ Tampere, Sch Publ Hlth, FIN-33014 Tampere, Finland.
   Occupat Hlth Ctr, Tampere, Finland.
C3 Tampere University
RP Salonen, P (corresponding author), Univ Tampere, Sch Publ Hlth, FIN-33014 Tampere, Finland.
EM pahasa@saunalahti.fi
OI Huhtala, Heini/0000-0003-1372-430X; nygard,
   clas-hakan/0000-0002-6962-7042
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NR 38
TC 1
Z9 2
U1 0
U2 4
PU SPRINGER FRANCE
PI PARIS
PA 22 RUE DE PALESTRO, PARIS, 75002, FRANCE
SN 1279-7707
EI 1760-4788
J9 J NUTR HEALTH AGING
JI J. Nutr. Health Aging
PD MAY-JUN
PY 2006
VL 10
IS 3
BP 193
EP 202
PG 10
WC Geriatrics & Gerontology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Nutrition & Dietetics
GA 044TL
UT WOS:000237695200004
PM 16622582
DA 2025-06-11
ER

PT J
AU Al-Okbi, SY
   Hamed, TE
   Elewa, TA
   Ramadan, AA
   Bakry, BA
   El Karamany, MF
AF Al-Okbi, S. Y.
   Hamed, T. E.
   Elewa, T. A.
   Ramadan, A. A.
   Bakry, B. A.
   El Karamany, M. F.
TI Quinoa seed: A source of lipophilic nutraceuticals for the prevention of
   metabolic syndrome in a rat model
SO GRASAS Y ACEITES
LA English
DT Article
DE Fatty acids; Fructose; Lipophilic extracts; Metabolic syndrome; Quinoa
   seed; Tocopherol
ID CHENOPODIUM-QUINOA; FATTY-ACIDS; FISH-OIL; SERUM; WILLD.; PRECIPITATION;
   EXTRACTION; AMARANTH
AB Metabolic syndrome (MS) is a cluster of metabolic changes including hypertriglyceridemia, elevated glucose tolerance and fatty liver. The aim of this research was to study the bioactivity of petroleum ether extracts prepared from quinoa 1 and Hualhuas quinoa in a MS rat model. Fatty acids and alpha-tocopherol were assessed in the extracts. MS was induced by feeding a high fructose -high fat diet (HFFD). Four groups of rats were assigned: the control group, fed a balanced diet; the control group, fed a HFFD diet; and two test groups, fed on a HFFD diet and treated by either quinoa 1 or hualhuas extract. The Glucose tolerance, plasma lipids, oxidative stress biomarkers, liver lipids and histopathology of the liver and heart were assessed. The results showed that extracts from both quinoa varieties had the potential to prevent MS; although quinoa 1 was more effective. In both varieties, the major fatty acid was linoleic. Hualhuas showed a higher percentage of linolenic acid than quinoa 1; while more alpha-tocopherol was present in quinoa1.
C1 [Al-Okbi, S. Y.; Hamed, T. E.; Ramadan, A. A.] Natl Res Ctr, Nutr & Food Sci Dept, El Buhouth St, Dokki, Cairo, Egypt.
   [Elewa, T. A.; Bakry, B. A.; El Karamany, M. F.] Natl Res Ctr, Field Crops Res Dept, El Buhouth St, Dokki, Cairo, Egypt.
C3 Egyptian Knowledge Bank (EKB); National Research Centre (NRC); Egyptian
   Knowledge Bank (EKB); National Research Centre (NRC)
RP Al-Okbi, SY (corresponding author), Natl Res Ctr, Nutr & Food Sci Dept, El Buhouth St, Dokki, Cairo, Egypt.
EM S_Y_alokbi@hotmail.com
RI ; Ramadan Taha, Asmaa/JFK-9971-2023
OI Bakry, Bakry/0000-0002-7695-3401; Ramadan Taha,
   Asmaa/0000-0003-2626-0006; Al-Okbi, Sahar Y./0000-0002-8114-2718
FU National Research Centre;  [11030126]
FX The authors would like to thank the National Research Centre for
   financing this research. The work was completely implemented in the
   National Research Centre (grant No .11030126)
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NR 30
TC 1
Z9 1
U1 1
U2 2
PU CONSEJO SUPERIOR INVESTIGACIONES CIENTIFICAS-CSIC
PI MADRID
PA Editorial CSIC, C/VITRUVIO 8, 28006 MADRID, SPAIN
SN 0017-3495
EI 1988-4214
J9 GRASAS ACEITES
JI Grasas Aceites
PD JAN-MAR
PY 2024
VL 75
IS 1
AR e542
DI 10.3989/gya.1104222
PG 11
WC Chemistry, Applied; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Food Science & Technology
GA NZ9O3
UT WOS:001204395000001
OA gold
DA 2025-06-11
ER

PT J
AU Marycz, K
   Michalak, I
   Kornicka, K
AF Marycz, Krzysztof
   Michalak, Izabela
   Kornicka, Katarzyna
TI Advanced nutritional and stem cells approaches to prevent equine
   metabolic syndrome
SO RESEARCH IN VETERINARY SCIENCE
LA English
DT Review
DE Metabolic syndrome; Algae; Mesenchymal stem cells; Diabetes; Insulin
   resistance; Obesity; Nutrition
ID BIOLOGICAL FEED SUPPLEMENT; MESENCHYMAL STROMAL CELLS; PANCREATIC
   BETA-CELLS; INSULIN-RESISTANCE; OXIDATIVE STRESS; SKELETAL-MUSCLE;
   ADIPOSE-TISSUE; FATTY-ACID; CHEMICAL-COMPOSITION; BIOSORPTION PROCESS
AB Horses metabolic disorders have become an important problem of modern veterinary medicine. Pathological obesity, insulin resistance and predisposition toward laminitis are associated with Equine Metabolic Syndrome (EMS). Based on pathogenesis of EMS, dietary and cell therapy management may significantly reduce development of this disorder. Special attention has been paid to the diet supplementation with highly bioavailable minerals and mesenchymal stem cells (MSC) which increase insulin sensitivity. In nutrition, there is a great interests in natural algae enriched via biosorption process with micro-and macroelements. In the case of cellular therapy, metabolic condition of engrafted cells may be crucial for the effectiveness of the therapy. Although, recent studies indicated on MSC deterioration in EMS individuals. Here, we described the combined nutritional and stem cells therapy for the EMS treatment. Moreover, we specified in details how EMS affects the adipose derived stem cells (ASC) population. Presented here, combined kind of therapy-an innovative and cutting edge approach of metabolic disorders treatment may become a new gold standard in personalized veterinary medicine.
C1 [Marycz, Krzysztof; Kornicka, Katarzyna] Wroclaw Univ Environm & Life Sci, Dept Expt Biol, PL-50630 Wroclaw, Poland.
   [Marycz, Krzysztof; Kornicka, Katarzyna] Wroclaw Res Ctr EIT, PL-54066 Wroclaw, Poland.
   [Michalak, Izabela] Wroclaw Univ Sci & Technol, Fac Chem, Dept Adv Mat Technol, Smoluchowskiego 25, PL-50372 Wroclaw, Poland.
C3 Wroclaw University of Environmental & Life Sciences; Wroclaw University
   of Science & Technology
RP Kornicka, K (corresponding author), Wroclaw Univ Environm & Life Sci, Dept Expt Biol, CK Norwida 27B, PL-50375 Wroclaw, Poland.
EM katarzyna.kornicka@upwr.edu.pl
RI Michalak, Izabela/P-3770-2015
OI Michalak, Izabela/0000-0001-8084-9642
FU National Science Centre in Poland [2015/18/ E/NZ9/00607,
   2016/21/B/NZ7/01111]; Wroclaw Centre of Biotechnology, programme the
   Leading National Research Centre (KNOW)
FX This manuscript was supported by the project entitled "The effect of
   bioactive algae enriched by biosorption on the certain minerals such as
   Cr(III), Mg(II) and Mn(II) on the status of glucose in the course of
   metabolic syndrome horses. Evaluation in vitro and in vivo" (2015/18/
   E/NZ9/00607) and "Modulation mitochondrial metabolism and dynamics and
   tageting DNA methylation of adipose derived mesenchymal stromal stem
   cell (ASC) using resveratrol and 5-azacytydin as a therapeutic strategy
   in the course of Equine metabolic syndrome (EMS)" (2016/21/B/NZ7/01111)
   attributed by The National Science Centre in Poland. Publication was
   supported by Wroclaw Centre of Biotechnology, programme the Leading
   National Research Centre (KNOW) for years 2014-2018.
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NR 134
TC 13
Z9 15
U1 1
U2 35
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0034-5288
EI 1532-2661
J9 RES VET SCI
JI Res. Vet. Sci.
PD JUN
PY 2018
VL 118
BP 115
EP 125
DI 10.1016/j.rvsc.2018.01.015
PG 11
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA GJ1WU
UT WOS:000435059400018
PM 29421480
DA 2025-06-11
ER

PT J
AU Ghibu, S
   Decea, N
   Morgovan, C
   Mogosan, C
AF Ghibu, Steliana
   Decea, Nicoleta
   Morgovan, Claudiu
   Mogosan, Cristina
TI AN EXPERIMENTAL MODEL TO INDUCE METABOLIC SYNDROME IN RATS. THE FRUCTOSE
   - ENRICHED DIET
SO FARMACIA
LA English
DT Article
DE metabolic syndrome; rat fructose-enriched diet; research animal model
ID OXIDATIVE STRESS
AB The objective of this study was to induce metabolic syndrome (MS) in rats by means of a fructose-enriched diet (F, 60%). Twenty male Sprague-Dawley rats were randomized into 2 groups and fed for 3 months with standard chow (Control group) or with standard chow supplemented with fructose (F, 60%). After their sacrifice, blood was drawn and the following biochemical parameters were determined from the centrifuged plasma: triglycerides and malondialdehyde (MDA) - a marker of lipid peroxidation. The fructose diet induced a significant increase in glycaemia (5.60 +/- 0.07 vs 7.22 +/- 0.13 mM, p < 0.001), in systolic blood pressure (SBP 113.66 +/- 1.14 vs 130.61 +/- 0.80 mmHg, p < 0.001) and in the triglyceride values (61.86 +/- 4.86 vs 331.20 +/- 23.15 mg/dL, p < 0.001), without significant modification of rat body weight. Moreover, the plasma MDA level was 1.38 times higher in fructose-fed rats. Our results suggest that this experimental model could be used to induce metabolic alterations, such as hypertension, hyperglycaemia and dyslipidemia, alterations associated to lipid peroxidation.
C1 [Ghibu, Steliana; Mogosan, Cristina] Iuliu Hatieganu Univ Med & Pharm, Fac Pharm, Dept Pharmacol Physiol & Physiopathol, Cluj Napoca, Romania.
   [Decea, Nicoleta] Iuliu Hatieganu Univ Med & Pharm, Fac Med, Dept Physiol, Cluj Napoca, Romania.
   [Morgovan, Claudiu] Vasile Goldis Western Univ Arad, Dept Pharm, Arad, Romania.
C3 Iuliu Hatieganu University of Medicine & Pharmacy; Iuliu Hatieganu
   University of Medicine & Pharmacy; Vasile Goldis Western University of
   Arad
RP Morgovan, C (corresponding author), Vasile Goldis Western Univ Arad, Dept Pharm, Arad, Romania.
EM claudiumorgovan@yahoo.com
RI Ghibu, Steliana/X-4723-2019; Mogosan, Cristina/H-9901-2016; Morgovan,
   Claudiu/C-4748-2011
OI Ghibu, Steliana/0000-0003-2247-4613; Morgovan,
   Claudiu/0000-0003-2730-8729
FU CNCSIS - UEFISCDI [PNII - PD 473/2010]
FX This work was supported by CNCSIS - UEFISCDI, project number PNII - PD
   473/2010.
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NR 15
TC 9
Z9 9
U1 0
U2 22
PU SOC STINTE FARMACEUTICE ROMANIA
PI BUCURESTI
PA BUCURESTI, STR TRAIAN VUIA 6, SECT 1, BUCURESTI, 020956, ROMANIA
SN 0014-8237
J9 FARMACIA
JI Farmacia
PD MAR-APR
PY 2013
VL 61
IS 2
BP 420
EP 426
PG 7
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 128ZD
UT WOS:000317807300020
DA 2025-06-11
ER

PT J
AU Leung, LYL
   Chan, SMN
   Tam, HL
   Wong, ESW
AF Leung, Leona Yuen-Ling
   Chan, Sidney Man-Ngai
   Tam, Hon-Lon
   Wong, Emily Sze-Wan
TI Astaxanthin Influence on Health Outcomes of Adults at Risk of Metabolic
   Syndrome: A Systematic Review and Meta-Analysis
SO NUTRIENTS
LA English
DT Review
DE astaxanthin; cardiometabolic disease; metabolic syndrome; systematic
   review; meta-analysis
ID OXIDATIVE STRESS
AB The use of medication is effective in managing metabolic syndrome (MetS), but side effects have led to increased attention on using nutraceuticals and supplements. Astaxanthin shows positive effects in reducing the risk of MetS, but results from individual studies are inconclusive. This systematic review summarizes the latest evidence of astaxanthin in adults with risk factors of MetS. A systematic search of English and Chinese randomized controlled trials in 14 electronic databases from inception to 30 June 2021 was performed. Two reviewers independently screened the titles and abstracts, and conducted full-text review, quality appraisal, and extraction of data. Risk of bias was assessed by PEDro. A total of 7 studies met the inclusion criteria with 321 participants. Six studies were rated to have excellent methodological quality, while the remaining one was rated at good. Results show marginal effects of astaxanthin on reduction in total cholesterol and systolic blood pressure, and a significant attenuating effect on low-density lipoprotein cholesterol. Further robust evidence is needed to examine the effects of astaxanthin in adults at risk of MetS.
C1 [Leung, Leona Yuen-Ling] Ronin Inst, Montclair, NJ 07043 USA.
   [Leung, Leona Yuen-Ling] Hong Kong Food Sci & Technol Assoc, Hong Kong, Peoples R China.
   [Leung, Leona Yuen-Ling] Canadian Acad Independent Scholars, Vancouver, BC V6B 5K3, Canada.
   [Chan, Sidney Man-Ngai; Wong, Emily Sze-Wan] Hong Kong Metropolitan Univ, Sch Sci & Technol, Hong Kong, Peoples R China.
   [Tam, Hon-Lon] Kiang Wu Nursing Coll Macau, Dept Educ, Macau 999078, Peoples R China.
   [Tam, Hon-Lon] Hong Kong Polytech Univ, Sch Nursing, Hong Kong, Peoples R China.
C3 Hong Kong Metropolitan University; Kiang Wu Nursing College of Macau;
   Hong Kong Polytechnic University
RP Wong, ESW (corresponding author), Hong Kong Metropolitan Univ, Sch Sci & Technol, Hong Kong, Peoples R China.; Tam, HL (corresponding author), Kiang Wu Nursing Coll Macau, Dept Educ, Macau 999078, Peoples R China.; Tam, HL (corresponding author), Hong Kong Polytech Univ, Sch Nursing, Hong Kong, Peoples R China.
EM leonaleung@ronininstitute.org; mnchan@hkmu.edu.hk; alantam@kwnc.edu.mo;
   eswwong@hkmu.edu.hk
RI Leung, Leona/AHE-8456-2022; Wong, Emily/IAP-2216-2023; Tam, Hon
   Lon/W-1371-2019
OI Tam, Hon Lon/0000-0003-0344-6262; Leung, Yuen Ling/0000-0003-2704-7805;
   Wong, Emily Sze Wan/0000-0001-7030-2299
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NR 35
TC 13
Z9 13
U1 2
U2 8
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD MAY
PY 2022
VL 14
IS 10
AR 2050
DI 10.3390/nu14102050
PG 16
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 1R2NN
UT WOS:000803212100001
PM 35631193
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Fuentes, E
   Fuentes, F
   Vilahur, G
   Badimon, L
   Palomo, I
AF Fuentes, Eduardo
   Fuentes, Francisco
   Vilahur, Gemma
   Badimon, Lina
   Palomo, Ivan
TI Mechanisms of Chronic State of Inflammation as Mediators That Link Obese
   Adipose Tissue and Metabolic Syndrome
SO MEDIATORS OF INFLAMMATION
LA English
DT Review
ID TUMOR-NECROSIS-FACTOR; CCAAT/ENHANCER BINDING-PROTEIN; ADIPONECTIN
   GENE-EXPRESSION; C-REACTIVE PROTEIN; CARDIOVASCULAR RISK-FACTORS; PRIMES
   HUMAN MONOCYTES; TNF-ALPHA THERAPY; GAMMA PPAR-GAMMA; OXIDATIVE STRESS;
   CIRCULATING ADIPONECTIN
AB The metabolic syndrome is a cluster of cardiometabolic alterations that include the presence of arterial hypertension, insulin resistance, dyslipidemia, and abdominal obesity. Obesity is associated with a chronic inflammatory response, characterized by abnormal adipokine production, and the activation of proinflammatory signalling pathways resulting in the induction of several biological markers of inflammation. Macrophage and lymphocyte infiltration in adipose tissue may contribute to the pathogenesis of obesity-mediated metabolic disorders. Adiponectin can either act directly on macrophages to shift polarization and/or prime human monocytes into alternative M2-macrophages with anti-inflammatory properties. Meanwhile, the chronic inflammation in adipose tissue is regulated by a series of transcription factors, mainly PPARs and C/EBPs, that in conjunction regulate the expression of hundreds of proteins that participate in the metabolism and storage of lipids and, as such, the secretion by adipocytes. Therefore, the management of the metabolic syndrome requires the development of new therapeutic strategies aimed to alter the main genetic pathways involved in the regulation of adipose tissue metabolism.
C1 [Fuentes, Eduardo; Palomo, Ivan] Univ Talca, Fac Hlth Sci, Dept Clin Biochem & Immunohematol, Immunol & Haematol Lab,Interdisciplinary Excellen, Talca, Chile.
   [Fuentes, Eduardo; Palomo, Ivan] CEAP, Talca, Chile.
   [Fuentes, Francisco] Univ Catolica Maule, Fac Med, Escuela Med, Santiago, Chile.
   [Vilahur, Gemma; Badimon, Lina] Inst Carlos III, CiberOBN, Hosp Santa Creu & Sant Pau, ICCC CSIC,Ctr Invest Cardiovasc, Barcelona, Spain.
C3 Universidad de Talca; Universidad Catolica del Maule; Hospital of Santa
   Creu i Sant Pau; CIBER - Centro de Investigacion Biomedica en Red;
   CIBEROBN; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC -
   Institut Catala de Ciencies Cardiovasculars (ICCC)
RP Palomo, I (corresponding author), Univ Talca, Fac Hlth Sci, Dept Clin Biochem & Immunohematol, Immunol & Haematol Lab,Interdisciplinary Excellen, Talca, Chile.
EM ipalomo@utalca.cl
RI BADIMON, LINA/S-2950-2019; Palomo, Iván/I-4321-2018; JIMENEZ,
   FRANCISCO/G-4311-2016; Fuentes, Eduardo/I-2889-2017; Badimon,
   Lina/O-4711-2014
OI Fuentes, Eduardo/0000-0003-0099-4108; Badimon, Lina/0000-0002-9162-2459;
   Palomo, Ivan/0000-0002-9618-8778
FU CONICYT REGIONAL/GORE, Programa de Investigacion de Excelencia
   Interdisciplinaria en Envejecimiento Saludable (PIEI-ES)
   [MAULE/CEAP/R09I2001]; Fondecyt, Chile [1130216]; PNS from the Spanish
   Ministry of Science [SAF2010-16549]; Insituto Carlos-III [CIBEROBN06];
   Science and Education Spanish Ministry (MICINN, Spain) [RyC-2009-5495]
FX This work was funded by the CONICYT REGIONAL/GORE MAULE/CEAP/R09I2001,
   Programa de Investigacion de Excelencia Interdisciplinaria en
   Envejecimiento Saludable (PIEI-ES), and supported by Grant no. 1130216
   (I.P., M.G., R.M., M.A., J.C.) from Fondecyt, Chile, by PNS
   SAF2010-16549 (to Lina Badimon) from the Spanish Ministry of Science and
   CIBEROBN06 Insituto Carlos-III (to Lina Badimon). The authors thank
   Fundacion Jesus Serra, Barcelona, for their continuous support. Gemma
   Vilahur is a recipient of a Grant from the Science and Education Spanish
   Ministry (RyC-2009-5495, MICINN, Spain).
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NR 158
TC 152
Z9 164
U1 0
U2 22
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 0962-9351
EI 1466-1861
J9 MEDIAT INFLAMM
JI Mediat. Inflamm.
PY 2013
VL 2013
AR 136584
DI 10.1155/2013/136584
PG 11
WC Cell Biology; Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Immunology
GA 169NE
UT WOS:000320786200001
PM 23843680
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Swiatkiewicz, I
   Nuszkiewicz, J
   Wroblewska, J
   Nartowicz, M
   Sokolowski, K
   Sutkowy, P
   Rajewski, P
   Buczkowski, K
   Chudzinska, M
   Manoogian, ENC
   Taub, PR
   Wozniak, A
AF Swiatkiewicz, Iwona
   Nuszkiewicz, Jaroslaw
   Wroblewska, Joanna
   Nartowicz, Malgorzata
   Sokolowski, Kamil
   Sutkowy, Pawel
   Rajewski, Pawel
   Buczkowski, Krzysztof
   Chudzinska, Malgorzata
   Manoogian, Emily N. C.
   Taub, Pam R.
   Wozniak, Alina
TI Feasibility and Cardiometabolic Effects of Time-Restricted Eating in
   Patients with Metabolic Syndrome
SO NUTRIENTS
LA English
DT Article
DE time-restricted eating; metabolic syndrome; abdominal obesity; body
   weight; elevated blood pressure; impaired glucose metabolism;
   cardiometabolic risks; circadian rhythm; eating window; m-health
   applications
ID CARDIOVASCULAR RISK; HEART-DISEASE; HEALTH; MANAGEMENT; WEIGHT; TRENDS;
   IMPACT; POPULATION; PREVALENCE; PATTERNS
AB Metabolic syndrome (MetS) and a prolonged daily eating window (EW) are associated with circadian rhythm disruption and increased cardiometabolic risk. Misalignment between circadian timing system and daily rhythms of food intake adversely impacts metabolic regulatory mechanisms and cardiovascular function. Restricting the daily EW by imposing an eating-fasting cycle through time-restricted eating (TRE) can restore robust circadian rhythms, support cellular metabolism, and improve cardiometabolic health. The aim of this study was to assess a feasibility of 12-week TRE intervention with self-selected 10 h EW and effects of TRE on EW duration, cardiometabolic outcomes, daily rhythms of behavior, and wellbeing in Polish patients with MetS and EW >= 14 h/day. Dietary intake was monitored with a validated myCircadianClock application (mCC app). Adherence to TRE defined as the proportion of days recorded with mCC app in which participants satisfied 10-h TRE was the primary outcome. A total of 26 patients (aged 45 +/- 13 years, 62% women, 3.3 +/- 0.5 MetS criteria, EW 14 +/- 1.5 h/day) were enrolled. Coexistence of increased waist circumference (WC) (96% of patients), elevated fasting plasma glucose (FPG) (77%), and elevated blood pressure (BP) (69%) was the most common MetS pattern (50%). TRE intervention (mean duration of 81.6 +/- 12.6 days) led to reducing daily EW by 28% (p < 0.0001). Adherence to TRE was 87 +/- 13%. Adherence to logging food intake on mCC app during TRE was 70 +/- 27%. Post TRE, a decrease in body weight (2%, 1.7 +/- 3.6 kg, p = 0.026), body mass index (BMI) (1%, 0.5 +/- 1.2 kg/m(2), p = 0.027), WC (2%, 2.5 +/- 3.9 cm, p = 0.003), systolic BP (4%, 4.8 +/- 9.0 mmHg, p = 0.012), FPG (4%, 3.8 +/- 6.9 mg/dL, p = 0.037), glycated hemoglobin (4%, 0.2 +/- 0.4%, p = 0.011), mean fasting glucose level from continuous glucose monitor (CGM) (4%, 4.0 +/- 6.1 mg/dL, p = 0.002), and sleepiness score (25%, 1.9 +/- 3.2 points, p = 0043) were observed. A significant decrease in body weight (2%), BMI (2%), WC (3%), mean CGM fasting glucose (6%), sleepiness score (27%), and depression score (60%) was found in patients with mean post-TRE EW <= 10 h/day (58% of total), and not in patients with EW > 10 h/day. Adherence to TRE was higher in patients with post-TRE EW <= 10 h/day vs. patients with EW > 10 h/day (94 +/- 6% vs. 77 +/- 14%, p = 0.003). Our findings indicate that 10-h TRE was feasible in the European MetS population. TRE resulted in reducing daily EW and improved cardiometabolic outcomes and wellbeing in patients with MetS and prolonged EW. Use of the mCC app can aid in implementing TRE. This pilot clinical trial provides exploratory data that are a basis for a large-scale randomized controlled trial to determine the efficacy and sustainability of TRE for reducing cardiometabolic risks in MetS populations. Further research is needed to investigate the mechanisms of TRE effects, including its impact on circadian rhythm disruption.
C1 [Swiatkiewicz, Iwona; Taub, Pam R.] Univ Calif San Diego, Div Cardiovasc Med, La Jolla, CA 92037 USA.
   [Nuszkiewicz, Jaroslaw; Wroblewska, Joanna; Sokolowski, Kamil; Sutkowy, Pawel; Wozniak, Alina] Nicolaus Copernicus Univ, Dept Med Biol & Biochem, Coll Medicum, PL-85092 Bydgoszcz, Poland.
   [Nartowicz, Malgorzata] Prof Franciszek Lukaszczyk Mem Hosp, Oncol Ctr, Clin Nutr Team, PL-85796 Bydgoszcz, Poland.
   [Rajewski, Pawel] Ctr Obes & Metab Disorders Treatment, PL-85676 Bydgoszcz, Poland.
   [Rajewski, Pawel] Univ Hlth Sci Bydgoszcz, Fac Hlth Sci, PL-87800 Bydgoszcz, Poland.
   [Buczkowski, Krzysztof] Nicolaus Copernicus Univ Torun, Dept Family Med, Coll Medicum Bydgoszcz, Torun, Poland.
   [Chudzinska, Malgorzata] Nicolaus Copernicus Univ, Dept Neurosurg & Neurol, Coll Medicum, Bydgoszcz, Poland.
   [Manoogian, Emily N. C.] Salk Inst Biol Studies, Regulatory Biol Lab, La Jolla, CA 92037 USA.
C3 University of California System; University of California San Diego;
   Nicolaus Copernicus University; Nicolaus Copernicus University; Nicolaus
   Copernicus University; Salk Institute
RP Swiatkiewicz, I (corresponding author), Univ Calif San Diego, Div Cardiovasc Med, La Jolla, CA 92037 USA.
EM iswiatkiewicz@health.ucsd.edu; jnuszkiewicz@cm.umk.pl;
   jwroblewskapraca@gmail.com; nartowiczgosia@gmail.com;
   sokolowskikamil@tlen.pl; p.sutkowy@cm.umk.pl; rajson@wp.pl;
   buczkowskik@cm.umk.pl; malgorzata.chudzinska1@wp.pl;
   emanoogian@salk.edu; ptaub@health.ucsd.edu; al1103@cm.umk.pl
RI Wróblewska, Joanna/G-8607-2014; Chudzinska, Malgorzata/AAZ-7227-2021;
   Swiatkiewicz, Iwona/H-4279-2014; Buczkowski, Krzysztof/H-7696-2014;
   Wozniak, Alina/H-4699-2014; Nuszkiewicz, Jaroslaw/AAI-6787-2021;
   Sutkowy, Pawel/G-9282-2014
OI Taub, Pam/0000-0002-0684-0655; Manoogian, Emily
   Nicole/0000-0001-9718-9310; Wroblewska, Joanna/0000-0002-8188-8296;
   Buczkowski, Krzysztof/0000-0002-7700-0952; Rajewski,
   Pawel/0000-0001-9796-8840; Wozniak, Alina/0000-0002-4492-4796;
   Nuszkiewicz, Jaroslaw/0000-0003-1378-5065; Sutkowy,
   Pawel/0000-0002-3479-7738
FX For the TREMNIOS pilot clinical trial, the mCC app was customized and a
   sub-study dashboard on the server side was created by E.N.C.M. at the
   Salk Institute for Biological Studies, La Jolla, CA, USA. E.N.C.M. from
   the Salk Institute, who is also a member of the research team of this
   study, is the administrator of data collected on the server using the
   mCC app. We thank Satchin Panda from the Salk Institute for Biological
   Studies, La Jolla, CA, USA for valuable discussions about this study.
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NR 65
TC 3
Z9 3
U1 0
U2 4
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JUN
PY 2024
VL 16
IS 12
AR 1802
DI 10.3390/nu16121802
PG 26
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA WT3V1
UT WOS:001257094500001
PM 38931157
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Li, YH
   Zhang, ZM
   Zhang, ZM
   Zheng, NN
   Ding, XD
AF Li, Yunhao
   Zhang, Zhanming
   Zhang, Zheming
   Zheng, Ningning
   Ding, Xudong
TI Empagliflozin, a sodium-glucose cotransporter inhibitor enhancing
   mitochondrial action and cardioprotection in metabolic syndrome
SO JOURNAL OF CELLULAR PHYSIOLOGY
LA English
DT Article
DE cardiomyocyte; empagliflozin; metabolic syndrome; mitochondria
ID CHAIN AMINO-ACIDS; DNA COPY NUMBER; CARDIAC NA+/H+ EXCHANGER;
   PERIPHERAL-BLOOD; SGLT2 INHIBITORS; SKELETAL-MUSCLE; HEART-FAILURE;
   FAILING HEART; DYSFUNCTION; ENERGY
AB Metabolic syndrome (MetS) has a large clinical population nowadays, usually due to excessive energy intake and lack of exercise. During MetS, excess nutrients stress the mitochondria, resulting in relative hypoxia in tissues and organs, even when blood supply is not interrupted or reduced, making mitochondrial dysfunction a central pathogenesis of cardiovascular disease in the MetS. Sodium-glucose cotransporter 2 inhibitors were designed as a hyperglycemic drug that acts on the renal tubules to block sugar reabsorption in primary urine. Recently they have been shown to have anti-inflammatory and other protective effects on cardiomyocytes in MetS, and have also been recommended in the latest heart failure guidelines as a routine therapy. Among these inhibitors, empagliflozin shows better clinical promise due to less influence from glomerular filtration rate. This review focuses on the mitochondrial mechanisms of empagliflozin, which underlie the anti-inflammatory and recover cellular functions in MetS cardiomyocytes, including stabilizing calcium concentration, mediating metabolic reprogramming, maintaining homeostasis of mitochondrial quantity and quality, stable mitochondrial DNA copy number, and repairing damaged mitochondrial DNA.
C1 [Li, Yunhao; Zhang, Zheming] China Med Univ, Grad Sch, Shenyang, Peoples R China.
   [Li, Yunhao] Gen Hosp Northern Theater Command, Dept Cardiol, Shenyang, Peoples R China.
   [Zhang, Zhanming] Univ Hong Kong, Fac Sci, Hong Kong, Peoples R China.
   [Zhang, Zheming] China Med Univ, Hosp 1, Dept Thorac Surg, Shenyang, Peoples R China.
   [Zheng, Ningning] China Med Univ, Coll Basic Med Sci, Dept Pathophysiol, Shenyang, Peoples R China.
   [Ding, Xudong] China Med Univ, Dept Anesthesiol, Shengjing Hosp, 36 Sanhao St, Shenyang, Peoples R China.
C3 China Medical University; University of Hong Kong; China Medical
   University; China Medical University; China Medical University
RP Ding, XD (corresponding author), China Med Univ, Dept Anesthesiol, Shengjing Hosp, 36 Sanhao St, Shenyang, Peoples R China.
EM dingxd@sj-hospital.org
RI Zhang, Zhan-Ming/IZQ-3053-2023; Zheng, Ningning/KHU-0389-2024; Li,
   Yunhao/HCI-0205-2022
OI Li, Yunhao/0000-0002-5359-2930
FU Natural Science Foundation of Liaoning Province [2022-MS-236]; Natural
   Science Foundation of Liaoning Province of China
FX The work was supported by the Natural Science Foundation of Liaoning
   Province of China (FUND#2022-MS-236).
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NR 141
TC 0
Z9 0
U1 5
U2 8
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0021-9541
EI 1097-4652
J9 J CELL PHYSIOL
JI J. Cell. Physiol.
PD JUN
PY 2024
VL 239
IS 6
DI 10.1002/jcp.31264
EA MAY 2024
PG 17
WC Cell Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Physiology
GA UD6I2
UT WOS:001226805200001
PM 38764242
DA 2025-06-11
ER

PT J
AU Carresi, C
   Gliozzi, M
   Musolino, V
   Scicchitano, M
   Scarano, F
   Bosco, F
   Nucera, S
   Maiuolo, J
   Macrì, R
   Ruga, S
   Oppedisano, F
   Zito, MC
   Guarnieri, L
   Mollace, R
   Tavernese, A
   Palma, E
   Bombardelli, E
   Fini, M
   Mollace, V
AF Carresi, Cristina
   Gliozzi, Micaela
   Musolino, Vincenzo
   Scicchitano, Miriam
   Scarano, Federica
   Bosco, Francesca
   Nucera, Saverio
   Maiuolo, Jessica
   Macri, Roberta
   Ruga, Stefano
   Oppedisano, Francesca
   Zito, Maria Caterina
   Guarnieri, Lorenza
   Mollace, Rocco
   Tavernese, Annamaria
   Palma, Ernesto
   Bombardelli, Ezio
   Fini, Massimo
   Mollace, Vincenzo
TI The Effect of Natural Antioxidants in the Development of Metabolic
   Syndrome: Focus on Bergamot Polyphenolic Fraction
SO NUTRIENTS
LA English
DT Review
DE metabolic syndrome; plant extracts; natural antioxidant; polyphenols;
   bergamot
ID DIET-INDUCED OBESITY; FATTY LIVER-DISEASE; INSULIN-RESISTANCE;
   ADIPOSE-TISSUE; TNF-ALPHA; ORAL BIOAVAILABILITY; 3T3-L1 ADIPOCYTES;
   PROTEIN-KINASE; CINNAMIC ACID; CARNOSIC ACID
AB Metabolic syndrome (MetS) represents a set of clinical findings that include visceral adiposity, insulin-resistance, high triglycerides (TG), low high-density lipoprotein cholesterol (HDL-C) levels and hypertension, which is linked to an increased risk of developing type 2 diabetes mellitus (T2DM) and atherosclerotic cardiovascular disease (ASCVD). The pathogenesis of MetS involves both genetic and acquired factors triggering oxidative stress, cellular dysfunction and systemic inflammation process mainly responsible for the pathophysiological mechanism. In recent years, MetS has gained importance due to the exponential increase in obesity worldwide. However, at present, it remains underdiagnosed and undertreated. The present review will summarize the pathogenesis of MetS and the existing pharmacological therapies currently used and focus attention on the beneficial effects of natural compounds to reduce the risk and progression of MetS. In this regard, emerging evidence suggests a potential protective role of bergamot extracts, in particular bergamot flavonoids, in the management of different features of MetS, due to their pleiotropic anti-oxidative, anti-inflammatory and lipid-lowering effects.
C1 [Carresi, Cristina; Gliozzi, Micaela; Musolino, Vincenzo; Scicchitano, Miriam; Scarano, Federica; Bosco, Francesca; Nucera, Saverio; Maiuolo, Jessica; Macri, Roberta; Ruga, Stefano; Oppedisano, Francesca; Zito, Maria Caterina; Guarnieri, Lorenza; Mollace, Rocco; Tavernese, Annamaria; Palma, Ernesto; Bombardelli, Ezio; Mollace, Vincenzo] Magna Graecia Univ Catanzaro, Inst Res Food Safety & Hlth IRC FSH, I-88100 Catanzaro, Italy.
   [Mollace, Rocco; Tavernese, Annamaria] Univ Roma Tor Vergata, Dept Med, Chair Cardiol, I-00133 Rome, Italy.
   [Palma, Ernesto; Bombardelli, Ezio; Fini, Massimo; Mollace, Vincenzo] Nutramed Scarl, Complesso Nini Barbieri, I-88021 Catanzaro, Italy.
   [Fini, Massimo] IRCCS San Raffaele Pisana, I-00163 Rome, Italy.
C3 Magna Graecia University of Catanzaro; University of Rome Tor Vergata;
   IRCCS San Raffaele Pisana
RP Carresi, C (corresponding author), Magna Graecia Univ Catanzaro, Inst Res Food Safety & Hlth IRC FSH, I-88100 Catanzaro, Italy.
EM carresi@unicz.it; micaela.gliozzi@gmail.com; xabaras3@hotmail.com;
   miriam.scicchitano@hotmail.it; federicascar87@gmail.com;
   boscofrancesca.bf@libero.it; saverio.nucera@hotmail.it;
   jessicamaiuolo@virgilio.it; robertamacri85@gmail.com; rugast1@gmail.com;
   oppedisanof@libero.it; mariacaterina.zito@studenti.unicz.it;
   lorenzacz808@gmail.com; rocco.mollace@gmail.com; an.tavernese@gmail.com;
   palma@unicz.it; ezio.bombardelli@plantexresearch.it;
   massimo.fini@sanraffaele.it; mollace@libero.it
RI MACRI', Roberta/AAC-5967-2022; Bosco, Francesca/HPF-0108-2023; Maiuolo,
   Jessica/AAU-2482-2020; nucera, saverio/AAC-6570-2022; SCARANO,
   FEDERICA/HNC-2414-2023; Gliozzi, Micaela/D-4405-2015; Fini,
   Massimo/AAA-9948-2021; Ruga, Stefano/JUV-6384-2023; Oppedisano,
   Francesca/GRJ-8297-2022; Musolino, Vincenzo/AAC-6429-2022; Mollace,
   Rocco/ABH-5643-2020; carresi, cristina/AAC-6354-2022
OI nucera, saverio/0000-0002-0000-4015; Musolino,
   Vincenzo/0000-0002-4763-2211; Mollace, Rocco/0000-0002-7106-5595; PALMA,
   Ernesto/0000-0003-4199-207X; MACRI', Roberta/0000-0002-2345-6751;
   Oppedisano, Francesca/0000-0003-0930-8987; Guarnieri,
   Lorenza/0009-0007-5865-8779; Ruga, Stefano/0009-0008-0401-4027; SCARANO,
   FEDERICA/0000-0002-9838-9469; tavernese, annamaria/0000-0002-2940-3482;
   Bosco, Francesca/0009-0004-4766-9710; carresi,
   cristina/0000-0002-3509-5930
FU  [PON-MIUR 03PE000_78_1];  [PONMIUR 03PE000_78_2]
FX This work has been supported by PON-MIUR 03PE000_78_1 and PONMIUR
   03PE000_78_2.
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NR 120
TC 48
Z9 49
U1 0
U2 27
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD MAY
PY 2020
VL 12
IS 5
AR 1504
DI 10.3390/nu12051504
PG 24
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA MB0AV
UT WOS:000542272700157
PM 32455840
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Pei, LG
   Yuan, C
   Guo, YT
   Kou, H
   Xia, LP
   Zhang, L
   Yan, YE
   Xu, D
   Wang, H
AF Pei, Lin-guo
   Yuan, Chao
   Guo, Yi-tian
   Kou, Hao
   Xia, Li-ping
   Zhang, Li
   Yan, You-e
   Xu, Dan
   Wang, Hui
TI Prenatal caffeine exposure induced high susceptibility to metabolic
   syndrome in adult female offspring rats and its underlying mechanisms
SO REPRODUCTIVE TOXICOLOGY
LA English
DT Article
DE Prenatal caffeine exposure; Metabolic syndrome; Catch-up growth; Insulin
   resistance
ID CORONARY-HEART-DISEASE; FATTY LIVER-DISEASE; CHOLESTEROL RATIO;
   STEROIDOGENIC FACTOR-1; PROGRAMMING ALTERATION; INSULIN-RESISTANCE;
   EARLY NUTRITION; FETAL; GROWTH; MODEL
AB Our previous studies have demonstrated that prenatal caffeine exposure (PCE) induced an intrauterine programming of hypothalamic-pituitary-adrenal axis (HPAA)-associated neuroendocrine metabolism in 3-month-old offspring rats. In this study, we aimed to confirm this programming disorder and high susceptibility to metabolic syndrome (MS) in 10-month-old female PCE offspring with postnatal catch-up growth. We found that PCE female offspring rats showed decreased bodyweight but a higher rate of weight gain after birth. Moreover, in the offspring, basal hyperinsulinemia and insulin resistance were observed before unpredictable chronic stress (UCS), but serum total cholesterol (TCH) levels and triglyceride/high-density lipoprotein-cholesterol (TG/HDL-C), TCH/HDL-C and low-density lipoprotein-cholesterol/HDL-C (LDL-C/HDL-C) ratio changes were increased after UCS, accompanied by morphological damage of the related tissues. These results suggested that PCE adult female offspring rats were highly susceptible to MS, which is related to HPAA-associated neuroendocrine-metabolic programming disorder. (C) 2017 Elsevier Inc. All rights reserved.
C1 [Pei, Lin-guo; Yuan, Chao; Guo, Yi-tian; Kou, Hao; Xia, Li-ping; Zhang, Li; Yan, You-e; Xu, Dan; Wang, Hui] Wuhan Univ, Basic Med Sch, Dept Pharmacol, Wuhan 430071, Peoples R China.
   [Kou, Hao; Xia, Li-ping; Xu, Dan; Wang, Hui] Hubei Prov Key Lab Dev Originated Dis, Wuhan, Peoples R China.
   [Pei, Lin-guo] Nanyang Med Univ, Basic Med Coll, Nanyang 473061, Peoples R China.
C3 Wuhan University
RP Wang, H (corresponding author), Wuhan Univ, Basic Med Sch, Dept Pharmacol, Wuhan 430071, Peoples R China.
EM wanghui19@whu.edu.cn
FU National Natural Science Foundation of China [81220108026, 81430089,
   81673524]; Hubei Province Health and Family Planning Scientific Research
   Project [WJ2017C0003]; Young Investigator Program of Zhongnan Hospital
   of Wuhan University [2015A02]
FX This work was supported by grants from the National Natural Science
   Foundation of China (Nos.81220108026, 81430089, 81673524), Hubei
   Province Health and Family Planning Scientific Research Project (No.
   WJ2017C0003), and Young Investigator Program of Zhongnan Hospital of
   Wuhan University (No. 2015A02).
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   Zhang L, ARCH MED RES, V44
NR 55
TC 11
Z9 12
U1 0
U2 14
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0890-6238
J9 REPROD TOXICOL
JI Reprod. Toxicol.
PD AUG
PY 2017
VL 71
BP 150
EP 158
DI 10.1016/j.reprotox.2017.06.045
PG 9
WC Reproductive Biology; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Reproductive Biology; Toxicology
GA FC3KD
UT WOS:000406736600021
PM 28625926
DA 2025-06-11
ER

PT J
AU Afsar, B
   Elsurer, R
   Sezer, S
   Ozdemir, NF
AF Afsar, Baris
   Elsurer, Rengin
   Sezer, Siren
   Ozdemir, Nurhan F.
TI Does Metabolic Syndrome Have an Impact on the Quality of Life and Mood
   of Hemodialysis Patients?
SO JOURNAL OF RENAL NUTRITION
LA English
DT Article
ID STAGE RENAL-DISEASE; INSULIN-RESISTANCE; PHYSICAL-ACTIVITY;
   HEALTH-STATUS; DEPRESSION; ASSOCIATION; MORTALITY; SYMPTOMS;
   HOSPITALIZATION; MALNUTRITION
AB Objective: Little is known about the association between metabolic syndrome (MetSyn), health-related quality of life (HRQoL), and depressive symptoms in hemodialysis (HD) patients. We hypothesized that MetSyn may be associated with lower HRQoL and depression in HD patients.
   Design: This was a cross-sectional study.
   Setting: The trial involved HID patients at a tertiary-care hospital.
   Patients: We evaluated 115 patients (41 women and 74 men; mean age, 48.4 +/- SD 11.9 years SD).
   Methods: MetSyn was defined according to National Cholesterol Education Panel criteria. The Medical Outcomes Study Short Form-36 (SF-36) and Beck Depression Inventory (BDI) were used to assess HRQoL and signs of depression, respectively. We compared HRQoL and clinical and psychosocial characteristics among participants with and without MetSyn.
   Results: Fifty patients (43.5%) had MetSyn, and 65 patients (56.5%) were free of MetSyn. Comparisons of SF-36 and BDI scores between HID patients with and without MetSyn revealed no statistically significant differences. The Physical Component Summary Score (PCS) of SF-36 was independently associated with HD duration (beta = -0.274, P = .002), age (beta = -0.206, P =.024), sleep disturbance (beta = -0.175, P = .045), albumin (beta = +0.252, P = .006), and hemoglobin (beta = +0.270, P = .002) in stepwise linear regression analysis. The MetSyn was not associated with PCS. The Mental Component Summary Score of SF-36 was independently associated with hemoglobin (beta = +0.235, P = .016) and BDI score (beta = -0.218, P =.025).
   Conclusions: The presence of MetSyn was not associated with HRQoL according to the Mental Component Summary Score. In HID patients, HRQoL and depressive behaviors were not influenced by MetSyn, but by various other factors. (C) 2009 by the National Kidney Foundation, Inc. All rights reserved.
C1 [Afsar, Baris; Elsurer, Rengin; Sezer, Siren; Ozdemir, Nurhan F.] Baskent Univ Hosp, Dept Nephrol, TR-06500 Ankara, Turkey.
C3 Baskent University
RP Afsar, B (corresponding author), Baskent Univ Hosp, Dept Nephrol, 3 Cadde 50 Sokak 9-8, TR-06500 Ankara, Turkey.
EM afsarbrs@yahoo.com
RI sezer, siren/JYQ-2550-2024; Elsurer, Rengin/HJH-6083-2023; Ozdemir Acar,
   Fatma Nurhan/AAK-1697-2021
OI Sezer, Siren/0000-0002-7326-8388; Ozdemir Acar, Fatma
   Nurhan/0000-0002-5682-0943
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NR 32
TC 7
Z9 8
U1 0
U2 0
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 1051-2276
EI 1532-8503
J9 J RENAL NUTR
JI J. Renal Nutr.
PD SEP
PY 2009
VL 19
IS 5
BP 365
EP 371
DI 10.1053/j.jrn.2009.01.016
PG 7
WC Nutrition & Dietetics; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics; Urology & Nephrology
GA 529JC
UT WOS:000272511000003
PM 19464928
DA 2025-06-11
ER

PT J
AU Kim, TE
   Kim, DY
   Kim, H
   Kim, SH
AF Kim, Tae-Eun
   Kim, Do Young
   Kim, Hyeongsu
   Kim, Sung Hea
TI Sex and Age Differences in the Impact of Metabolic Syndrome on Heart
   Failure Development
SO METABOLITES
LA English
DT Review
DE metabolic syndrome; heart failure; sex difference; young age
ID HIGH-DENSITY-LIPOPROTEIN; ISCHEMIA-REPERFUSION INJURY; C-REACTIVE
   PROTEIN; CARDIOVASCULAR-DISEASE; INSULIN-RESISTANCE; PRESSURE-OVERLOAD;
   OXIDATIVE STRESS; YOUNG-ADULTS; FOLLOW-UP; ASSOCIATION
AB Metabolic syndrome (MetS), a cluster of metabolic dysregulations, is recognized as a significant risk factor for the development of heart failure (HF). The pathophysiological mechanisms linking MetS to HF are complex and multifaceted, with the components of MetS contributing to cardiac deterioration through impaired myocardial energy metabolism, increased inflammation, and endothelial dysfunction. Numerous clinical studies have confirmed the relationship between MetS and HF. Multiple studies have demonstrated that the impact of MetS on HF varies by sex and age. Metabolic disorders, including MetS, have a greater impact on HF incidence in younger adults compared to the elderly population and in women compared to men. Although the reasons for these differences are not yet fully understood, recognizing the sex- and age-related variations is crucial for developing targeted strategies to prevent HF in individuals with MetS. Future research should continue to investigate the underlying mechanisms behind these variations and identify optimal management approaches that account for both sex and age in reducing HF risk.
C1 [Kim, Tae-Eun] Konkuk Univ, Med Ctr, Dept Clin Pharmacol, Seoul 05030, South Korea.
   [Kim, Do Young] Ajou Univ Hosp, Ajou Sch Med, Dept Internal Med, Div Cardiol, Suwon 16499, South Korea.
   [Kim, Hyeongsu] Konkuk Univ, Sch Med, Dept Prevent Med, Seoul 05030, South Korea.
   [Kim, Sung Hea] Konkuk Univ, Sch Med, Med Ctr, Dept Internal Med,Div Cardiol, Seoul 05030, South Korea.
C3 Konkuk University; Konkuk University Medical Center; Ajou University;
   Ajou University Hospital; Konkuk University; Konkuk University Medical
   Center; Konkuk University; Konkuk University Medical Center
RP Kim, SH (corresponding author), Konkuk Univ, Sch Med, Med Ctr, Dept Internal Med,Div Cardiol, Seoul 05030, South Korea.
EM shkim@kuh.ac.kr
RI Kim, Jin-Seok/AAK-5424-2020; Kim, Yong Won/AAA-2134-2022
OI Kim, Hyeongsu/0000-0002-5379-134X
FU Konkuk University Medical Center Research [K230114]; Konkuk University
   Medical Center Research Grant
FX This research was funded by the Konkuk University Medical Center
   Research Grant K230114.
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NR 74
TC 0
Z9 0
U1 2
U2 2
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2218-1989
J9 METABOLITES
JI Metabolites
PD DEC
PY 2024
VL 14
IS 12
AR 653
DI 10.3390/metabo14120653
PG 11
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA Q5A6T
UT WOS:001384810900001
PM 39728435
OA gold
DA 2025-06-11
ER

PT J
AU Martins, CC
   Bagatini, MD
   Cardoso, AM
   Zanini, D
   Abdalla, FH
   Baldissarelli, J
   Dalenogare, DP
   dos Santos, DL
   Schetinger, MRC
   Morsch, VMM
AF Martins, C. C.
   Bagatini, M. D.
   Cardoso, A. M.
   Zanini, D.
   Abdalla, F. H.
   Baldissarelli, J.
   Dalenogare, D. P.
   dos Santos, D. L.
   Schetinger, M. R. C.
   Morsch, V. M. M.
TI Exercise Training positively modulates the Ectonucleotidase Enzymes in
   Lymphocytes of Metabolic Syndrome Patients
SO INTERNATIONAL JOURNAL OF SPORTS MEDICINE
LA English
DT Article
DE metabolic syndrome; E-NTPDase; ADA; exercise training; inflammation
ID ADENOSINE-DEAMINASE ACTIVITIES; NTPDASE; SERUM; INFLAMMATION;
   ACTIVATION; PLATELETS; STRESS; CD39
AB In this study, we investigated the cardiovascular risk factors as well as ectonucleotidase activities in lymphocytes of metabolic syndrome (MetS) patients before and after an exercise intervention. 20 MetS patients, who performed regular concurrent exercise training for 30 weeks, 3 times/week, were studied. Anthropometric, biochemical, inflammatory and hepatic parameters and hydrolysis of adenine nucleotides and nucleoside in lymphocytes were collected from patients before and after 15 and 30 weeks of the exercise intervention as well as from participants of the control group. An increase in the hydrolysis of ATP and ADP, and a decrease in adenosine deamination in lymphocytes of MetS patients before the exercise intervention were observed (P<0.001). However, these alterations were reversed by exercise training after 30 weeks of intervention. Additionally, exercise training reduced the inflammatory and hepatic markers to baseline levels after 30 weeks of exercise. Our results clearly indicated alteration in ectonucleotidase enzymes in lymphocytes in the MetS, whereas regular exercise training had a protective effect on the enzymatic alterations and on inflammatory and hepatic parameters, especially if it is performed regularly and for a long period.
C1 [Martins, C. C.; Cardoso, A. M.; Zanini, D.; Abdalla, F. H.; Baldissarelli, J.; Dalenogare, D. P.; dos Santos, D. L.; Schetinger, M. R. C.; Morsch, V. M. M.] Univ Fed Santa Maria, Dept Bioquim & Biol Mol, Santa Maria, RS, Brazil.
   [Bagatini, M. D.; Cardoso, A. M.] Univ Fed Fronteira Sul, Coordenacao Acad, SC 484,Km 02, BR-89812000 Chapeco, Brazil.
C3 Universidade Federal de Santa Maria (UFSM); Universidade Federal da
   Fronteira Sul
RP Bagatini, MD (corresponding author), Univ Fed Fronteira Sul, Coordenacao Acad, SC 484,Km 02, BR-89812000 Chapeco, Brazil.
EM margaretebagatini@yahoo.com.br
RI Schetinger, Maria/JAC-4640-2023; Morsch, Vera/M-6215-2014; dos Santos,
   Daniela/AAU-2310-2021; Cardoso, Andréia/ABH-9732-2020; Padilha
   Dalenogare, Diéssica/IUM-5367-2023; Zanini, Daniela/KEH-7499-2024;
   Bagatini, Margarete/K-3756-2016; Baldissarelli, Jucimara/U-4563-2017
OI Bagatini, Margarete/0000-0001-9263-4980; Cardoso,
   Andreia/0000-0003-4243-8855; Baldissarelli,
   Jucimara/0000-0002-1114-0063; Chitolina Schetinger, Maria
   Rosa/0000-0002-5240-8935; Santos, Daniela/0000-0002-1782-1337; Morsch,
   Vera Maria/0000-0002-5381-4556
FU Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
   [304641/2013-8]; Fundacao de Amparo a Pesquisa do Rio Grande do Sul
   (FAPERGS) [1279-2551/13-7]; Coordenacao de Aperfeicoamento de Pessoal de
   Nivel Superior (CAPES); FINEP research grant "Rede Instituto Brasileiro
   de Neurociencia (IBN-Net)"; "Instituto Nacional de Ciencia e Tecnologia"
   (INCT)
FX The authors wish to thank the Conselho Nacional de Desenvolvimento
   Cientifico e Tecnologico (CNPq) under Grant number 304641/2013-8,
   Fundacao de Amparo a Pesquisa do Rio Grande do Sul (FAPERGS) under Grant
   number 1279-2551/13-7, Coordenacao de Aperfeicoamento de Pessoal de
   Nivel Superior (CAPES), the FINEP research grant "Rede Instituto
   Brasileiro de Neurociencia (IBN-Net)" and "Instituto Nacional de Ciencia
   e Tecnologia" (INCT) for their financial support of this work.
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NR 36
TC 8
Z9 9
U1 0
U2 4
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0172-4622
EI 1439-3964
J9 INT J SPORTS MED
JI Int. J. Sports Med.
PD NOV
PY 2016
VL 37
IS 12
BP 930
EP 936
DI 10.1055/s-0042-114218
PG 7
WC Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Sport Sciences
GA EC1RL
UT WOS:000387884900002
PM 27626502
DA 2025-06-11
ER

PT J
AU Yang, WQ
   Wang, XH
   Kang, CY
   Yang, LY
   Liu, D
   Zhao, N
   Zhang, XY
AF Yang, Wanqiu
   Wang, Xiaohong
   Kang, Chuanyi
   Yang, Liying
   Liu, Di
   Zhao, Na
   Zhang, Xiangyang
TI Establishment of a risk prediction model for suicide attempts in
   first-episode and drug naive patients with major depressive disorder
SO ASIAN JOURNAL OF PSYCHIATRY
LA English
DT Article
DE Major depression; Suicide attempts; Nomogram; Risk factor
ID NATIONAL-HEALTH; METABOLIC SYNDROME; ASSOCIATION; YOUNG; CHOLESTEROL;
   PREVALENCE; BEHAVIOR; SCALE; DISTURBANCES; THYROTROPIN
AB Background: Suicide is common in patients with major depressive disorder (MDD) and has serious consequences for individuals and families. This study aims to establish a risk prediction model for suicide attempts in MDD patients to make the detection of suicide risk more accurate and effective.
   Methods: A cross-sectional survey, clinical examination, and biochemical indicator tests were performed on 1718 first-episode and drug nai <spacing diaeresis>ve patients with major depressive disorder. We used Machine Learning to establish a risk prediction model for suicide attempts in FEDN patients with MDD.
   Results: Five predictors were identified by LASSO regression analysis from a total of 20 variables studied, namely psychotic symptoms, anxiety symptoms, thyroid peroxidase antibodies (ATPO), total cholesterol (TC), and highdensity lipoprotein-cholesterol (HDL-C). The model constructed using the five predictors displayed moderate predictive ability, with an area under the ROC of 0.771 in the training set and 0.720 in the validation set. The DCA curve showed that the nomogram could be applied clinically if the risk threshold was between 22 % and 60 %. The risk threshold was found to be between 20 % and 60 % in external validation.
   Conclusion: Introducing psychotic symptoms, anxiety symptoms, ATPO, TC, and HDL-C to the risk nomogram increased its usefulness for predicting suicide risk in patients with MDD. It may be useful in clinical decisionmaking or in discussions with patients, especially in crisis interventions.
C1 [Yang, Wanqiu] Yunnan Univ, Sch Ethnol & Sociol, Kunming, Yunnan, Peoples R China.
   [Yang, Wanqiu] Yunnan Univ, Sch Med, Kunming, Yunnan, Peoples R China.
   [Wang, Xiaohong; Kang, Chuanyi; Zhao, Na] Harbin Med Univ, Affiliated Hosp 1, Dept Psychiat, Harbin, Peoples R China.
   [Yang, Liying] Dalian Mental Hlth Ctr, Dalian Peoples Hosp 7, Dalian, Peoples R China.
   [Liu, Di] Harbin Med Univ, Sch Marxism, Harbin, Peoples R China.
   [Zhang, Xiangyang] Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China.
   [Zhang, Xiangyang] Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China.
C3 Yunnan University; Yunnan University; Harbin Medical University; Harbin
   Medical University; Chinese Academy of Sciences; Institute of
   Psychology, CAS; Chinese Academy of Sciences; University of Chinese
   Academy of Sciences, CAS
RP Zhao, N (corresponding author), Harbin Med Univ, Affiliated Hosp 1, Harbin, Heilongjiang, Peoples R China.; Zhang, XY (corresponding author), 16 Lincui Rd, Beijing 100101, Peoples R China.
EM zhaona@hrbmu.edu.cn; zhangxy@psych.ac.cn
RI Zhang, Xiangyang/ABC-7380-2022; wang, wangxiaohong/IXN-2340-2023
OI Zhang, Xiangyang/0000-0003-3326-382X; LIU, DI/0000-0001-9268-4099
FU Double First Class University Plan; Yunnan University; National Key R
   amp; D Program of China [2017YFE0103700]; First Affiliated Hospital of
   Harbin Medical University [2021B22]
FX We are grateful to all the patients, physicians, and research staff that
   participated in our current study. This study was supported in part by
   grants from the Double First Class University Plan, the " China Rural
   Social Surve " of Yunnan University, the National Key R & amp; D Program
   of China (2017YFE0103700) , and the First Affiliated Hospital of Harbin
   Medical University (2021B22) .
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NR 63
TC 7
Z9 7
U1 2
U2 13
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1876-2018
EI 1876-2026
J9 ASIAN J PSYCHIATR
JI Asian J. Psychiatr.
PD OCT
PY 2023
VL 88
AR 103732
DI 10.1016/j.ajp.2023.103732
EA AUG 2023
PG 10
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychiatry
GA R1WQ5
UT WOS:001062317800001
PM 37586124
DA 2025-06-11
ER

PT J
AU Mayneris-Perxachs, J
   Alcaide-Hidalgo, JM
   de la Hera, E
   del Bas, JM
   Arola, L
   Caimari, A
AF Mayneris-Perxachs, Jordi
   Maria Alcaide-Hidalgo, Juan
   de la Hera, Esther
   Maria del Bas, Josep
   Arola, Lluis
   Caimari, Antoni
TI Supplementation with biscuits enriched with hesperidin and naringenin is
   associated with an improvement of the Metabolic Syndrome induced by a
   cafeteria diet in rats
SO JOURNAL OF FUNCTIONAL FOODS
LA English
DT Article
DE Metabolic Syndrome; Cafeteria diet; Polyphenols; Citrus flavanones;
   Hesperidin; Naringenin
ID INSULIN-RESISTANCE; HIGH-FAT; GLUCOSYL HESPERIDIN; CHOLESTEROL; OBESITY;
   HYPERTENSION; POLYPHENOLS; PLASMA; LIVER; MECHANISMS
AB Metabolic syndrome (MetS) has become a major public health concern. Because of their numerous health promoting biological properties, polyphenols are potential candidates to ameliorate MetS and, recently, the incorporation of these compounds into widely consumed foodstuffs has emerged as a potential strategy to enhance their intake. Therefore, we aimed to assess the potential beneficial effects of biscuits enriched with the citrus polyphenols hesperidin and naringenin (HN) in rats that were fed either standard chow (STD) or an obesogenic cafeteria diet (CAF) for 16 weeks. The STD and CAF groups were supplemented with either control or FIN biscuits for the final 8 weeks of the study. CAF-fed rats developed MetS, characterized by obesity, insulin resistance, hypertension and dyslipidemia. FIN supplementation in CAF-fed rats ameliorated hypertension and insulin resistance and significantly reduced body weight, mesenteric adiposity, total cholesterol, LDL-C and oxidative stress. Hence, HN biscuits may be a promising functional food against MetS.
C1 [Mayneris-Perxachs, Jordi; Arola, Lluis; Caimari, Antoni] Joint Unit Univ Rovira & Virgili EURECAT, Ctr Tecnol Catalunya, Ctr Omic Sci, Unique Sci & Tech Infrastruct, Reus, Spain.
   [Mayneris-Perxachs, Jordi; Maria Alcaide-Hidalgo, Juan; Maria del Bas, Josep; Arola, Lluis; Caimari, Antoni] Eurecat, Ctr Tecnol Catalunya, Technol Unit Nutr & Hlth, Reus, Spain.
   [Arola, Lluis] Univ Rovira & Virgili, Nutrigen Res Grp, Dept Biochem & Biotechnol, Campus Sescelades, Tarragona, Spain.
   [de la Hera, Esther] IMASDEA, Ctr Res & Dev, El Espinar Segovia, Spain.
   [Mayneris-Perxachs, Jordi] Girona Biomed Res Inst IdIBGi, Nutr Eumetab & Hlth Grp, Girona, Spain.
C3 Universitat Rovira i Virgili; Universitat de Girona; Girona University
   Hospital Dr. Josep Trueta; Institut d'Investigacio Biomedica de Girona
   (IDIBGI)
RP Arola, L (corresponding author), Eurecat, Ctr Tecnol Catalunya, Biotechnol Area, Avinguda Univ 1, Reus 43204, Spain.
EM jmayneris@idibgi.org; juanmaria.alcaide@eurecat.org;
   Esther.delaHera@imasdea.org; josep.delbas@eurecat.org;
   lluis.arola@ce.eurecat.org; antoni.caimari@eurecat.org
RI del Bas, Josep/K-9310-2019; Mayneris-Perxachs, Jordi/AAG-7724-2020;
   Arola, Lluis/C-6074-2011; MAYNERIS-PERXACHS, JORDI/B-2589-2018
OI Arola, Lluis/0000-0003-2767-1974; MAYNERIS-PERXACHS,
   JORDI/0000-0003-3788-3815; Caimari, Antoni/0000-0001-6144-0294; Alcaide
   Hidalgo, Juan Maria/0000-0001-5705-7807; del Bas, Josep
   Maria/0000-0002-0700-2004
FU Agency for Business Competitiveness of the Government of Catalonia
   (ACCIO) [TECCT11-10012]; Center for the Development of Industrial
   Technology (CDTI) of the Spanish Ministry of Economy and Competitiveness
FX This work was supported by the Agency for Business Competitiveness of
   the Government of Catalonia (ACCIO) [TECCT11-10012] and by the Center
   for the Development of Industrial Technology (CDTI) of the Spanish
   Ministry of Economy and Competitiveness [CIEN project SMARTFOODS].
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NR 54
TC 18
Z9 19
U1 1
U2 23
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1756-4646
EI 2214-9414
J9 J FUNCT FOODS
JI J. Funct. Food.
PD OCT
PY 2019
VL 61
AR 103504
DI 10.1016/j.jff.2019.103504
PG 9
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA IW7WW
UT WOS:000485205700035
DA 2025-06-11
ER

PT J
AU Litvinova, L
   Atochin, DN
   Fattakhov, N
   Vasilenko, M
   Zatolokin, P
   Kirienkova, E
AF Litvinova, Larisa
   Atochin, Dmitriy N.
   Fattakhov, Nikolai
   Vasilenko, Manila
   Zatolokin, Pavel
   Kirienkova, Elena
TI Nitric oxide and mitochondria in metabolic syndrome
SO FRONTIERS IN PHYSIOLOGY
LA English
DT Review
DE metabolic syndrome; mitochondrial dysfunction; nitric oxide synthase;
   nitric oxide; nitric oxide synthase type I; nitric oxide synthase type
   II; oxide synthase type III; mitochondrial nitric oxide synthase
ID NECROSIS-FACTOR-ALPHA; OXIDATIVE STRESS; INSULIN-RESISTANCE; ENDOTHELIAL
   DYSFUNCTION; SKELETAL-MUSCLE; HAPLOGROUP N9A; DNA VARIANT; FATTY LIVER;
   OBESITY; EXPRESSION
AB Metabolic syndrome (MS) is a cluster of metabolic disorders that collectively increase the risk of cardiovascular disease. Nitric oxide (NO) plays a crucial role in the pathogeneses of MS components and is involved in different mitochondrial signaling pathways that control respiration and apoptosis. The present review summarizes the recent information regarding the interrelations of mitochondria and NO in MS. Changes in the activities of different NO synthase isoforms lead to the formation of metabolic disorders and therefore are highlighted here. Reduced endothelial NOS activity and NO bioavailability, as the main factors underlying the endothelial dysfunction that occurs in MS, are discussed in this review in relation to mitochondrial dysfunction. We also focus on potential therapeutic strategies involving NO signaling pathways that can be used to treat patients with metabolic disorders associated with mitochondrial dysfunction. The article may help researchers develop new approaches for the diagnosis, prevention and treatment of MS.
RP Litvinova, L (corresponding author), Kant Baltic Fed Univ, Lab Immunol Cellular Biotechnol, Innovat Pk,Botkina 3, Kaliningrad 236016, Kaliningrad, Russia.
EM larisalitvinova@yandex.ru
RI Atochin, Dmitriy/AAH-8843-2020; Fattakhov, Nikolai/AAD-6645-2020;
   Litvinova, Larisa/A-9672-2014; Vulf, Maria/E-4926-2017; Fattakhov,
   Nikolai/B-2170-2014; Kirienkova, Elena/B-2164-2014
OI Litvinova, Larisa/0000-0001-5231-6910; Vulf, Maria/0000-0002-4989-045X;
   Fattakhov, Nikolai/0000-0001-6707-9727; Kirienkova,
   Elena/0000-0002-5980-3321
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NR 91
TC 91
Z9 98
U1 1
U2 19
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-042X
J9 FRONT PHYSIOL
JI Front. Physiol.
PD FEB 17
PY 2015
VL 6
AR 20
DI 10.3389/fphys.2015.00020
PG 10
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA CG0BL
UT WOS:000352931500001
PM 25741283
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Maurantonio, M
   Ballestri, S
   Odoardi, MR
   Lonardo, A
   Loria, P
AF Maurantonio, Mauro
   Ballestri, Stefano
   Odoardi, Maria Rosaria
   Lonardo, Amedeo
   Loria, Paola
TI Treatment of Atherogenic Liver Based on the Pathogenesis of
   Nonalcoholic Fatty Liver Disease: A Novel Approach to Reduce
   Cardiovascular Risk?
SO ARCHIVES OF MEDICAL RESEARCH
LA English
DT Review
DE Atherosclerosis; Cardiovascular Risk; Metabolic syndrome; Nonalcoholic
   fatty liver disease; Pathogenesis; Treatment
ID GAMMA-GLUTAMYL-TRANSFERASE; C-REACTIVE PROTEIN; HEPATIC SUBCAPSULAR
   STEATOSIS; MUSCLE INSULIN-RESISTANCE; RENIN-ANGIOTENSIN SYSTEM;
   LIFE-STYLE INTERVENTION; VISCERAL ADIPOSE-TISSUE; TERM-FOLLOW-UP;
   METABOLIC SYNDROME; CRYPTOGENIC CIRRHOSIS
AB Nonalcoholic fatty liver disease (NAFLD), which spans a spectrum of conditions ranging from simple steatosis to progressive nonalcoholic steatohepatitis (NASH), is the most common chronic liver disease and a relevant public health issue. The prevalence of NAFLD depends on adiposity, age, gender and ethnicity. The natural history of liver disease in those with NAFLD critically depends on liver histological changes. However, cardiovascular mortality is increased in NAFLD, particularly in middle-aged adults. Against such a background, this review consists of three sections. First, data on NAFLD as a novel mechanism of increased cardiovascular risk via hyperinsulinism, prothrombotic potential, and subclinical inflammation are summarized. Next, the role of atherogenic liver in the development of manifestations of oxidative stress and atherosclerosis is emphasized. Finally, whether and how treating NAFLD will mechanistically result in reduced cardiovascular risk through ameliorated metabolic syndrome is discussed. (C) 2011 IMSS. Published by Elsevier Inc.
C1 [Maurantonio, Mauro; Ballestri, Stefano; Odoardi, Maria Rosaria; Lonardo, Amedeo; Loria, Paola] Univ Modena & Reggio Emilia, Nuovo Osped Civile St Agostino Estense Modena, Dept Internal Med Endocrinol Metab & Geriatr, I-41100 Modena, Italy.
C3 Universita di Modena e Reggio Emilia
RP Maurantonio, M (corresponding author), Univ Modena & Reggio Emilia, Dept Internal Med Metab Endocrinol & Geriatr, Operating Unit Internal Med, Nuovo Osped Civile Estense Baggiovara, I-41100 Modena, Italy.
EM m.maurantonio@ausl.mo.it
RI Ballestri, Stefano/AAQ-1541-2021; Lonardo, Amedeo/I-5911-2019
OI ballestri, stefano/0000-0002-1424-7894; Lonardo,
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NR 276
TC 33
Z9 35
U1 0
U2 7
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0188-4409
EI 1873-5487
J9 ARCH MED RES
JI Arch. Med. Res.
PD JUL
PY 2011
VL 42
IS 5
BP 337
EP 353
DI 10.1016/j.arcmed.2011.08.004
PG 17
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 830MR
UT WOS:000295661600001
PM 21843565
DA 2025-06-11
ER

PT J
AU Jacob, G
   Ocytil, Y
   Brenner, B
AF Jacob, Giris
   Ocytil, Yoab
   Brenner, Benjamin
TI The Overlooked Risk of Venous Thromboembolism in Psychiatric Patients:
   Epidemiology, Pathophysiology, and Implications for Clinical Care
SO SEMINARS IN THROMBOSIS AND HEMOSTASIS
LA English
DT Article
DE psychiatric diseases; venous thromboembolism; hypercoagulability;
   metabolic syndrome; antipsychotic drugs
ID PULMONARY-EMBOLISM; METABOLIC SYNDROME; DIABETES-MELLITUS;
   ANTIPSYCHOTIC-DRUGS; THROMBIN GENERATION; OXIDATIVE STRESS;
   MENTAL-ILLNESS; COAGULATION; SCHIZOPHRENIA; PREVALENCE
AB Psychiatric patients face a significantly shorter life expectancy than the general population due to a complex interplay of medical, behavioral, and social factors. Venous thromboembolism (VTE), encompassing both pulmonary embolism and deep vein thrombosis, is an underrecognized yet critical contributor to morbidity and mortality in this population. Evidence suggests a two to three times higher prevalence of VTE in psychiatric patients compared to the general population, with incidence rates up to 4.5 per 1,000 person-years. This elevated risk is attributed to a hypercoagulable-hypofibrinolytic state. It is influenced by metabolic abnormalities, pro-inflammatory pathways, antipsychotic medications, and genetic factors. Health care biases and reduced treatment compliance further exacerbate the burden. This review explores the epidemiology, pathophysiology, and mechanistic underpinnings of VTE in psychiatric populations, emphasizing the role of metabolic syndrome and antipsychotic therapy. To mitigate mortality and enhance outcomes for these high-risk individuals, it is imperative to address this issue through improved risk stratification and preventive strategies.
C1 [Jacob, Giris; Ocytil, Yoab] Sourasky Med Ctr, Internal Med, Tel Aviv, Israel.
   [Jacob, Giris] Sourasky Med Ctr, Recanati Res Ctr, Tel Aviv, Israel.
   [Jacob, Giris] Tel Aviv Univ, Fac Med, Tel Aviv, Israel.
   [Brenner, Benjamin] Rambam Hlth Care Campus, Dept Hematol, H_efa, Israel.
   [Brenner, Benjamin] Technion Israel Inst Technol, Fac Med, Haifa, Israel.
C3 Tel Aviv University; Sackler Faculty of Medicine; Tel Aviv Sourasky
   Medical Center; Tel Aviv University; Sackler Faculty of Medicine; Tel
   Aviv Sourasky Medical Center; Tel Aviv University; Rambam Health Care
   Campus; Technion Israel Institute of Technology; Rappaport Faculty of
   Medicine
RP Jacob, G (corresponding author), Tel Aviv Univ, Fac Med, Tel Aviv Sourasky Med Ctr, Internal Med Div, Tel Aviv, Israel.
EM jacobgi@tlvmc.gov.il
FU Jacob Recanati Research Funding, NYC, United States; Tel Aviv, Israel
FX The authors have received funding from Jacob Recanati Research Funding,
   NYC, United States and Tel Aviv, Israel.
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NR 98
TC 0
Z9 0
U1 2
U2 2
PU THIEME MEDICAL PUBL INC
PI NEW YORK
PA 333 SEVENTH AVE, NEW YORK, NY 10001 USA
SN 0094-6176
EI 1098-9064
J9 SEMIN THROMB HEMOST
JI Semin. Thromb. Hemost.
PD JUN
PY 2025
VL 51
IS 04
BP 430
EP 437
DI 10.1055/s-0044-1800968
EA DEC 2024
PG 8
WC Hematology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Hematology; Cardiovascular System & Cardiology
GA 2QB1B
UT WOS:001377294900001
PM 39672190
DA 2025-06-11
ER

PT J
AU Reyad-ul-Ferdous, M
   Song, YF
AF Reyad-ul-Ferdous, Md.
   Song, Yongfeng
TI Pharmacological potential of ferulic acid for the treatment of metabolic
   syndrome and its mechanism of action: Review
SO PHYSIOLOGY AND PHARMACOLOGY
LA English
DT Review
DE Obesity and Metabolic diseases; Lipid profiling and Glucose
   dysreg-ulation; Cardioprotective; Antioxidant; Inflammation and
   Hepatoprotective
ID HIGH-FAT DIET; PREVENTS LIVER-INJURY; INSULIN-RESISTANCE; OXIDATIVE
   STRESS; HIGH-CARBOHYDRATE; LIPID-METABOLISM; DIOSBULBIN B; RAT MODEL;
   IN-VIVO; INFLAMMATION
AB Recently, obesity causes vital mortality around the globe. Last decade, obesity-related diseases increased significantly worldwide. Even though, effective drugs are not available to treat metabolic diseases such as cardiovascular diseases, Parkinson's, obesity, and hypertension. Emergence and identifying new drug moieties to treat such metabolic diseases became imperative. Nature is a vital source of remedies and isolates new effective and nontoxic drug candidates. Ferulic acid is a significant phenolic compound that is abundant in various fruits, rice oil, and vegetables. This study highlighted the beneficial effects of ferulic acid for the treatment of metabolic syndrome or obesity. Similarly, in this study, we have highlighted the therapeutic purpose of ferulic acid in treating metabolic syndrome, its mechanism of action as well as its potential pharmacological effect using animal models. Further investigations are needed to demonstrate the significant mechanism of action in clinical trials using the human species.
C1 [Reyad-ul-Ferdous, Md.; Song, Yongfeng] Shandong Univ, Shandong Prov Hosp, Cheeloo Coll Med, Dept Endocrinol & Metab, Jinan, Peoples R China.
   [Reyad-ul-Ferdous, Md.] Shandong Univ, Cheeloo Coll Med, Dept Internal Med, Jinan, Shandong, Peoples R China.
   [Reyad-ul-Ferdous, Md.; Song, Yongfeng] Shandong Prov Key Lab Endocrinol & Lipid Metab, Jinan 250021, Shandong, Peoples R China.
   [Song, Yongfeng] Shandong First Med Univ, Shandong Prov Hosp, Dept Endocrinol & Metab, Jinan, Shandong, Peoples R China.
   [Reyad-ul-Ferdous, Md.; Song, Yongfeng] Shandong Acad Clin Med, Shandong Inst Endocrinol & Metab, Jinan 250021, Shandong, Peoples R China.
   [Reyad-ul-Ferdous, Md.; Song, Yongfeng] Shandong Engn Res Ctr Stem Cell & Gene Therapy End, Jinan 250021, Shandong, Peoples R China.
C3 Shandong First Medical University & Shandong Academy of Medical
   Sciences; Shandong University; Shandong University; Shandong First
   Medical University & Shandong Academy of Medical Sciences
RP Reyad-ul-Ferdous, M; Song, YF (corresponding author), Shandong Univ, Shandong Prov Hosp, Cheeloo Coll Med, Dept Endocrinol & Metab, Jinan, Peoples R China.; Reyad-ul-Ferdous, M (corresponding author), Shandong Univ, Cheeloo Coll Med, Dept Internal Med, Jinan, Shandong, Peoples R China.; Reyad-ul-Ferdous, M; Song, YF (corresponding author), Shandong Prov Key Lab Endocrinol & Lipid Metab, Jinan 250021, Shandong, Peoples R China.; Song, YF (corresponding author), Shandong First Med Univ, Shandong Prov Hosp, Dept Endocrinol & Metab, Jinan, Shandong, Peoples R China.; Reyad-ul-Ferdous, M; Song, YF (corresponding author), Shandong Acad Clin Med, Shandong Inst Endocrinol & Metab, Jinan 250021, Shandong, Peoples R China.; Reyad-ul-Ferdous, M; Song, YF (corresponding author), Shandong Engn Res Ctr Stem Cell & Gene Therapy End, Jinan 250021, Shandong, Peoples R China.
EM rockyreyad@sdu.edu.cn; songyf@sdu.edu.cn
RI Ferdous, Md. Reyad-ul-/AAK-6745-2021
OI Ferdous, Md. Reyad-ul/0000-0003-4775-6852; Song,
   yongfeng/0000-0001-8934-3154
FU National Natural Science Foundation; Shandong Provincial Natural Science
   Foundation;  [81922016];  [81870607];  [ZR2019JQ25]
FX Acknowledgment Funding This study was supported by grants from the
   National Natural Science Foundation (81922016, 81870607) and the
   Shandong Provincial Natural Science Foundation (ZR2019JQ25) of China.
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NR 96
TC 0
Z9 0
U1 1
U2 11
PU IRANIAN SOC PHYSIOLOGY & PHARMACOLOGY
PI TEHRAN
PA PO BOX 19615-1178, TEHRAN, 00000, IRAN
SN 2476-5236
EI 2476-5244
J9 PHYSIOL PHARMACOL
JI Physiol. Pharmacol.
PD DEC
PY 2022
VL 26
IS 4
BP 345
EP 362
DI 10.52547/phypha.26.4.8
PG 18
WC Physiology
WE Emerging Sources Citation Index (ESCI)
SC Physiology
GA 7S7TI
UT WOS:000910954000001
OA gold
DA 2025-06-11
ER

PT J
AU Liang, HL
   Cheng, PW
   Lin, HL
   Hao, CL
   Ke, LY
   Chou, HY
   Tseng, YH
   Yen, HW
   Shen, KP
AF Liang, Hsin-Li
   Cheng, Pei-Wen
   Lin, Hui-Li
   Hao, Chi-Long
   Ke, Liang-Yin
   Chou, Huei-Yin
   Tseng, Yu-Hsiu
   Yen, Hsueh-Wei
   Shen, Kuo-Ping
TI Extract of pre-germinated brown rice protects against cardiovascular
   dysfunction by reducing levels of inflammation and free radicals in a
   rat model of type II diabetes
SO JOURNAL OF FUNCTIONAL FOODS
LA English
DT Article
DE Metabolic syndrome; Cardiovascular complications; Extract of
   pre-germinated brown rice; SHR; T2DM
ID OXIDATIVE STRESS; METABOLIC SYNDROME; SYSTEMIC INFLAMMATION;
   CARDIAC-HYPERTROPHY; GLUCOSE-METABOLISM; RECEPTOR; FIBROSIS;
   CARDIOMYOPATHY; HYPERGLYCEMIA; EXPRESSION
AB The aim of this study was to examine the effect of extract of pre-germinated brown rice (EP) on metabolic and cardiovascular dysfunction in a rat model of T2DM. Hypertensive rats were divided into: (1) normal diet (ND group), (2) induced T2DM (DM group), and T2DM rats that were treated with (3) EP30 mg/kg (EP30 group) or (4) EP300 mg/kg (EP300 group) per day for 4 weeks. T2DM symptoms included: weight loss, hyperglycaemia, hypoinsulinemia, hyperlipidaemia, higher HbA1c, glucose in urine, and lower GLP-1. EP treatment improved metabolic parameters, activated insulin signalling, and increased lipid metabolism, and also ameliorated T2DMassociated increases in levels of inflammation, free radicals, cardiac hypertrophy and fibrosis. EP reduced T2DM and related cardiovascular complications by increasing insulin signalling and lipid metabolism, and reducing levels of inflammation and free radicals. Thus, EP may be a potential candidate for the treatment of metabolic syndrome and related cardiovascular complications.
C1 [Liang, Hsin-Li] Kaohsiung Vet Gen Hosp, Dept Crit Care Med, Kaohsiung, Taiwan.
   [Cheng, Pei-Wen] Kaohsiung Vet Gen Hosp, Dept Med Educ & Res, Kaohsiung, Taiwan.
   [Cheng, Pei-Wen] Natl Sun Yat Sen Univ, Inst Biomed Sci, Kaohsiung, Taiwan.
   [Lin, Hui-Li; Ke, Liang-Yin] Kaohsiung Med Univ, Lipid Sci & Aging Res Ctr, Kaohsiung, Taiwan.
   [Hao, Chi-Long] Pingtung Christian Hosp, Dept Internal Med, Div Cardiol, Pingtung, Taiwan.
   [Ke, Liang-Yin] Kaohsiung Med Univ Hosp, Ctr Lipid Biosci, Kaohsiung, Taiwan.
   [Ke, Liang-Yin] Kaohsiung Med Univ, Dept Med Lab Sci & Biotechnol, Kaohsiung, Taiwan.
   [Chou, Huei-Yin] Meiho Univ, Dept Hlth Business Adm, Pingtung, Taiwan.
   [Tseng, Yu-Hsiu] Natl Kaohsiung Univ Hosp & Tourism, Grad Inst Food Culture & Innovat, Kaohsiung, Taiwan.
   [Yen, Hsueh-Wei] Kaohsiung Med Univ Hosp, Dept Internal Med, Div Cardiol, Kaohsiung, Taiwan.
   [Shen, Kuo-Ping] Meiho Univ, Dept Nursing, 23 Ping Kuang Rd, Pingtung 91202, Taiwan.
C3 Kaohsiung Veterans General Hospital; Kaohsiung Veterans General
   Hospital; National Sun Yat Sen University; Kaohsiung Medical University;
   Kaohsiung Medical University; Kaohsiung Medical University Hospital;
   Kaohsiung Medical University; National Kaohsiung University of
   Hospitality & Tourism; Kaohsiung Medical University; Kaohsiung Medical
   University Hospital
RP Shen, KP (corresponding author), Meiho Univ, Dept Nursing, 23 Ping Kuang Rd, Pingtung 91202, Taiwan.
EM x00002148@meiho.edu.tw
RI Ke, Liang-Yin/A-2778-2009
FU Pingtung Christian Hospital, Pingtung, Taiwan [108-FI-DBS-IAC-R-001,
   107-FI-DBS-IAC-R-001]; Kaohsiung Veterans General Hosptial, Kaohsiung,
   Taiwan [MOST 105-2320-B-276-003-MY2, MOST 108-2320-B-276-002-MY3];
   Kaohsiung Veterans General Hospital [VGHMHU109-001]
FX This work was supported by grants from Pingtung Christian Hospital,
   Pingtung, Taiwan awarded to Dr. Kuo-Ping Shen (108-FI-DBS-IAC-R-001 and
   107-FI-DBS-IAC-R-001), and from the Kaohsiung Veterans General Hosptial,
   Kaohsiung, Taiwan, to Dr. Hui-Li Lin (MOST 105-2320-B-276-003-MY2) and
   to Dr. Kuo-Ping Shen (MOST 108-2320-B-276-002-MY3), as well as from
   Kaohsiung Veterans General Hospital to Dr. Kuo-Ping Shen
   (VGHMHU109-001). We would also like to thank Miss Tsui-Jung Lin for her
   technical advice and support.
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NR 61
TC 7
Z9 9
U1 0
U2 18
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1756-4646
EI 2214-9414
J9 J FUNCT FOODS
JI J. Funct. Food.
PD DEC
PY 2020
VL 75
AR 104218
DI 10.1016/j.jff.2020.104218
PG 12
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA PH4DG
UT WOS:000600364900015
OA gold
DA 2025-06-11
ER

PT J
AU Lee, WC
   Wu, KLH
   Leu, S
   Tain, YL
AF Lee, Wei-Chia
   Wu, Kay L. H.
   Leu, Steve
   Tain, You-Lin
TI Translational insights on developmental origins of metabolic syndrome:
   Focus on fructose consumption
SO BIOMEDICAL JOURNAL
LA English
DT Review
DE Developmental origins of health and disease (DOHaD); Fructose;
   Hypertension; Metabolic syndrome; Obesity
ID PROGRAMMED HYPERTENSION; INDUCED DYSLIPIDEMIA; OXIDATIVE STRESS; HUMAN
   PLACENTA; KIDNEY INJURY; CORN SYRUP; LATER LIFE; RAT; EXPOSURE; BLADDER
AB Metabolic syndrome (MetS) is a highly prevalent complex trait despite recent advances in pathophysiology and pharmacological treatment. MetS can begin in early life by so-called the developmental origins of health and disease (DOHaD). The DOHaD concept offers a novel approach to prevent MetS through reprogramming. High fructose (HF) intake has been associated with increased risk of MetS. HF diet becomes one of the most commonly used animal model to induce MetS. This review discusses the maternal HF diet induced programming process and reprogramming strategy to prevent MetS of developmental origin, with an emphasis on: (1) an overview of metabolic effects of fructose consumption on MetS; (2) insight from maternal HF animal models on MetS-related phenotypes; (3) impact of HF consumption induces organ-specific transcriptome changes; and (4) application of reprogramming strategy to prevent maternal HF consumption-induced MetS. Research into the preventions and treatments of MetS that begin early in life will have a lifelong impact and profound savings in disease burden and financial costs.
C1 [Lee, Wei-Chia] Kaohsiung Chang Gung Mem Hosp, Dept Urol, Kaohsiung, Taiwan.
   [Wu, Kay L. H.; Leu, Steve; Tain, You-Lin] Kaohsiung Chang Gung Mem Hosp, Inst Translat Res Biomed, Kaohsiung, Taiwan.
   [Tain, You-Lin] Kaohsiung Chang Gung Mem Hosp, Dept Pediat, 123 Dabi Rd, Kaohsiung 833, Taiwan.
   [Lee, Wei-Chia; Wu, Kay L. H.; Leu, Steve; Tain, You-Lin] Chang Gung Univ, Coll Med, Taoyuan, Taiwan.
C3 Chang Gung Memorial Hospital; Chang Gung Memorial Hospital; Chang Gung
   Memorial Hospital; Chang Gung University
RP Tain, YL (corresponding author), Kaohsiung Chang Gung Mem Hosp, Dept Pediat, 123 Dabi Rd, Kaohsiung 833, Taiwan.
EM tainyl@hotmail.com
RI Tain, You-Lin/H-2827-2019; Wu, Kay/ACD-1767-2022; Leu, Steve/D-6807-2011
OI Wu, Kay L.H./0000-0002-7297-6788; Tain, You-Lin/0000-0002-7059-6407;
   Lee, Wei-Chia/0000-0003-0701-2285
FU Chang Gung Medical Foundation [CMRPG8F0022, CMRPG8G0191, CGMPG8F0031,
   CGMPG8F0032]; Ministry of Science and Technology of the Republic of
   China, Taiwan [MOST 106-2314-B182A-100]
FX This work was supported by CMRPG8F0022 and CMRPG8G0191 (Y.L.T.), and
   CGMPG8F0031 and CGMPG8F0032 (J.Y.H.C.) from the Chang Gung Medical
   Foundation, and MOST 106-2314-B182A-100 (W.C.L.) from the Ministry of
   Science and Technology of the Republic of China, Taiwan.
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NR 47
TC 36
Z9 38
U1 0
U2 7
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 2319-4170
EI 2320-2890
J9 BIOMED J
JI Biomed. J.
PD APR
PY 2018
VL 41
IS 2
BP 96
EP 101
DI 10.1016/j.bj.2018.02.006
PG 6
WC Biochemistry & Molecular Biology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Research & Experimental Medicine
GA GI3FT
UT WOS:000434257700004
PM 29866605
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Van der Schueren, B
   Vangoitsenhoven, R
   Geeraert, B
   De Keyzer, D
   Hulsmans, M
   Lannoo, M
   Huber, HJ
   Mathieu, C
   Holvoet, P
AF Van der Schueren, B.
   Vangoitsenhoven, R.
   Geeraert, B.
   De Keyzer, D.
   Hulsmans, M.
   Lannoo, M.
   Huber, H. J.
   Mathieu, C.
   Holvoet, P.
TI Low cytochrome oxidase 4I1 links mitochondrial dysfunction to obesity
   and type 2 diabetes in humans and mice
SO INTERNATIONAL JOURNAL OF OBESITY
LA English
DT Article
ID CIRCULATING OXIDIZED LDL; LOW-DENSITY-LIPOPROTEIN; METABOLIC SYNDROME;
   OXIDATIVE STRESS; C-OXIDASE; MYOCARDIAL-INFARCTION; INSULIN SENSITIVITY;
   CARDIOVASCULAR-DISEASE; WEIGHT-LOSS; RISK
AB OBJECTIVES: Cytochrome oxidase (COX) dysfunction is associated with mitochondrial oxidative stress. We determined the association between COX expression, obesity and type 2 diabetes.
   SUBJECTS/METHODS: COX4I1 and COX10 genes were measured in monocytes of 24 lean controls, 31 glucose-tolerant and 67 diabetic obese patients, and 17 morbidly obese patients before and after bariatric surgery. We investigated the effect of caloric restriction and peroxisome proliferator-activated receptor (PPAR) agonist treatment on Cox in obese diabetic mice, and that of diet-induced insulin resistance in Streptozotocin-treated mice.
   RESULTS: Low COX4I1 was associated with type 2 diabetes in obese patients, adjusting for age, gender, smoking, interleukin-6 and high-sensitivity C-reactive protein, all related to metabolic syndrome (MetS; odds ratio: 6.1, 95% confidence interval: 2.3-16). In contrast, COX10 was low in glucose-tolerant and diabetic obese patients. In morbidly obese patients, COX4I1 was lower in visceral adipose tissue collected at bariatric surgery. In their monocytes, COX4I1 decreased after bariatric surgery, and low COX4I1 at 4 months was associated with MetS at 7 years. In leptin-deficient obese diabetic mice, Cox4i1 was low in white visceral adipose tissue (n = 13; P < 0.001) compared with age-matched lean mice (n = 10). PPAR.-agonist treatment (n = 13), but not caloric restriction (n = 11), increased Cox4i1 (P < 0.001). Increase in Cox4i1 depended on the increase in glucose transporter 4 (Glut4) expression and insulin sensitivity, independent of the increase in blood adiponectin. In streptozotocin-treated mice (three groups of seven mice, diet-induced insulin resistance decreased Cox4i1 and Glut4 (P < 0.001 for both).
   CONCLUSION: COX4I1 depression is related to insulin resistance and type 2 diabetes in obesity. In peripheral blood monocytes, it may be a diagnostically useful biomarker.
C1 [Van der Schueren, B.; Vangoitsenhoven, R.; Lannoo, M.; Mathieu, C.] Katholieke Univ Leuven, Lab Clin & Expt Med & Endocrinol, B-3000 Leuven, Belgium.
   [Geeraert, B.; De Keyzer, D.; Hulsmans, M.; Huber, H. J.; Holvoet, P.] Katholieke Univ Leuven, Dept Cardiovasc Sci, Div Atherosclerosis & Metab, B-3000 Leuven, Belgium.
C3 KU Leuven; KU Leuven
RP Holvoet, P (corresponding author), Katholieke Univ Leuven, Dept Cardiovasc Sci, Div Atherosclerosis & Metab, Herestr 49,O&N1, B-3000 Leuven, Belgium.
EM paul.holvoet@med.kuleuven.be
RI Hulsmans, Maarten/AAI-9547-2020; Vangoitsenhoven, Roman/B-3196-2018;
   lannoo, matthias/AAB-1706-2020; mathieu, chantal/ABD-5505-2021; HOLVOET,
   PAUL/T-8434-2017
OI Mathieu, Chantal/0000-0002-4055-5233; Holvoet, Paul/0000-0001-9201-0772;
   Van der Schueren, Bart/0000-0003-4754-784X; Lannoo,
   matthias/0000-0001-7815-1157; Hulsmans, Maarten/0000-0003-1009-658X;
   Vangoitsenhoven, Roman/0000-0003-3523-669X
FU Bijzonder Onderzoeksfonds of the KU Leuven [PF/10/014];
   Interdisciplinair Ontwikkelingsfonds-Kennisplatform [KP/12/009]; Fonds
   voor Wetenschappelijk Onderzoek-Vlaanderen [G0846.11]
FX We thank Roxane Menten for her excellent technical support. This work
   was funded by the Bijzonder Onderzoeksfonds of the KU Leuven (PF/10/014;
   Center of Excellence), by the Interdisciplinair
   Ontwikkelingsfonds-Kennisplatform (KP/12/009) and by the Fonds voor
   Wetenschappelijk Onderzoek-Vlaanderen (G0846.11 and Vascular Biology
   Network). MH is a postdoctoral fellow of the Fonds voor Wetenschappelijk
   Onderzoek-Vlaanderen.
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NR 47
TC 24
Z9 29
U1 0
U2 12
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0307-0565
EI 1476-5497
J9 INT J OBESITY
JI Int. J. Obes.
PD AUG
PY 2015
VL 39
IS 8
BP 1254
EP 1263
DI 10.1038/ijo.2015.58
PG 10
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA CR0BK
UT WOS:000360983000012
PM 25869607
DA 2025-06-11
ER

PT J
AU Huang, YH
   Tain, YL
   Hsu, CN
AF Huang, Ying-Hua
   Tain, You-Lin
   Hsu, Chien-Ning
TI Maternal Supplementation of Probiotics, Prebiotics or Postbiotics to
   Prevent Offspring Metabolic Syndrome: The Gap between Preclinical
   Results and Clinical Translation
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE obesity; hypertension; metabolic syndrome; hyperlipidemia; probiotics;
   prebiotics; postbiotics; developmental origins of health and disease
   (DOHaD)
ID HIGH-FAT DIET; LOW-BIRTH-WEIGHT; INDUCED PROGRAMMED HYPERTENSION;
   INCREASES BLOOD-PRESSURE; REDUCES NEPHRON NUMBER; IN-UTERO EXPOSURE; GUT
   MICROBIOTA; DEVELOPMENTAL ORIGINS; OXIDATIVE STRESS; NITRIC-OXIDE
AB Metabolic syndrome (MetS) is an extremely prevalent complex trait and it can originate in early life. This concept is now being termed the developmental origins of health and disease (DOHaD). Increasing evidence supports that disturbance of gut microbiota influences various risk factors of MetS. The DOHaD theory provides an innovative strategy to prevent MetS through early intervention (i.e., reprogramming). In this review, we summarize the existing literature that supports how environmental cues induced MetS of developmental origins and the interplay between gut microbiota and other fundamental underlying mechanisms. We also present an overview of experimental animal models addressing implementation of gut microbiota-targeted reprogramming interventions to avert the programming of MetS. Even with growing evidence from animal studies supporting the uses of gut microbiota-targeted therapies start before birth to protect against MetS of developmental origins, their effects on pregnant women are still unknown and these results require further clinical translation.
C1 [Huang, Ying-Hua; Tain, You-Lin] Kaohsiung Chang Gung Mem Hosp, Dept Pediat, Kaohsiung 833, Taiwan.
   [Tain, You-Lin] Chang Gung Univ, Coll Med, Taoyuan 333, Taiwan.
   [Hsu, Chien-Ning] Kaohsiung Chang Gung Mem Hosp, Dept Pharm, Kaohsiung 833, Taiwan.
   [Hsu, Chien-Ning] Kaohsiung Med Univ, Sch Pharm, Kaohsiung 807, Taiwan.
C3 Chang Gung Memorial Hospital; Chang Gung University; Chang Gung Memorial
   Hospital; Kaohsiung Medical University
RP Hsu, CN (corresponding author), Kaohsiung Chang Gung Mem Hosp, Dept Pharm, Kaohsiung 833, Taiwan.; Hsu, CN (corresponding author), Kaohsiung Med Univ, Sch Pharm, Kaohsiung 807, Taiwan.
EM crihsu@cgmh.org.tw
RI Hsu, Chien-Ning/GLS-4014-2022; Tain, You-Lin/H-2827-2019
OI Hsu, Chien-Ning/0000-0001-7470-528X; , Ying-Hua/0000-0003-0430-9745;
   Tain, You-Lin/0000-0002-7059-6407
FU Chang Gung Memorial Hospital, Kaohsiung, Taiwan [CORPG8M0151,
   CORPG8M0081, CMRPG8L1221, CORPG8L0301, CMRPG8L0961, CMRPG8M0751]
FX This research was funded by Chang Gung Memorial Hospital, Kaohsiung,
   Taiwan, grants CORPG8M0151, CORPG8M0081, CMRPG8L1221, CORPG8L0301,
   CMRPG8L0961, and CMRPG8M0751.
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NR 200
TC 8
Z9 8
U1 1
U2 14
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD SEP
PY 2022
VL 23
IS 17
AR 10173
DI 10.3390/ijms231710173
PG 21
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 4J2AL
UT WOS:000851071300001
PM 36077575
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Moukayed, M
   Grant, WB
AF Moukayed, Meis
   Grant, William B.
TI Linking the metabolic syndrome and obesity with vitamin D status: risks
   and opportunities for improving cardiometabolic health and well-being
SO DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
LA English
DT Review
DE vitamin D; metabolic syndrome; obesity; adipose tissue; cardiovascular
   disease; risk reduction
ID SERUM 25-HYDROXYVITAMIN D; D SUPPLEMENTATION; 1,25-DIHYDROXYVITAMIN D-3;
   ADIPOSE-TISSUE; D-RECEPTOR; OXIDATIVE STRESS; COLORECTAL-CANCER;
   DOSE-RESPONSE; ACTIVATION; INFLAMMATION
AB The global death toll from noncommunicable diseases is exceptionally high, reported to cause 71% of global deaths worldwide. Metabolic syndrome risk factors, especially excessive adiposity and obesity, are at the heart of the problem resulting in increased comorbidities such as cardiometabolic diseases and cancer, increased health costs, poorer quality of life, and shortened survival. Vitamin D-3 can positively reverse many of these adverse effects and outcomes through blocking signaling mechanisms that predispose to cardiometabolic and metastatic disease. As an affordable natural agent, vitamin D-3 can be used to counteract obesity-induced inflammation, block early adipogenesis, enhance glucose uptake, counteract hyperleptinemia, ameliorate insulin resistance, and reduce hypertension. This is supported by data from in vitro, in vivo and epidemiological studies and clinical trials. We propose that everyone in general and obese patients in particular consider raising 25-hydroxyvitamin D levels through UVB exposure and/or supplemental vitamin D(3 )intake to reduce cardiometabolic and metastatic disease and increase longevity.
C1 [Moukayed, Meis] Amer Univ Dubai, Sch Arts & Sci, Dubai, U Arab Emirates.
   [Grant, William B.] Sunlight Nutr & Hlth Res Ctr, POB 641603, San Francisco, CA 94164 USA.
C3 American University in Dubai (AUD)
RP Grant, WB (corresponding author), Sunlight Nutr & Hlth Res Ctr, POB 641603, San Francisco, CA 94164 USA.
EM wbgrant@infonline.net
RI Grant, William/B-8311-2009
OI Moukayed, Meis/0000-0003-3951-7712
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NR 85
TC 20
Z9 20
U1 0
U2 5
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-7007
J9 DIABETES METAB SYNDR
JI Diabetes Metab. Syndr. Obes.
PY 2019
VL 12
BP 1437
EP 1447
DI 10.2147/DMSO.S176933
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA IU2XZ
UT WOS:000483444600001
PM 31496777
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Sutra, T
   Oiry, C
   Azay-Milhau, J
   Youl, E
   Magous, R
   Teissèdre, PL
   Cristol, JP
   Cros, G
AF Sutra, Thibault
   Oiry, Catherine
   Azay-Milhau, Jacqueline
   Youl, Estelle
   Magous, Richard
   Teissedre, Pierre-Louis
   Cristol, Jean-Paul
   Cros, Gerard
TI Preventive Effects of Nutritional Doses of Polyphenolic Molecules on
   Cardiac Fibrosis Associated with Metabolic Syndrome: Involvement of
   Osteopontin and Oxidative Stress
SO JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
LA English
DT Article
DE Polyphenols; fructose; rat; collagen I; osteopontin; ROS
ID INSULIN-RESISTANCE; ANGIOTENSIN-II; NADPH OXIDASE; HEART; HYPERTENSION;
   HYPERTROPHY; MECHANISMS; EXPRESSION; DISEASE; KINASE
AB We previously showed that grape extracts enriched in different polyphenolic families were similarly able to prevent reactive oxygen species (ROS) production, although having differential effects on various features of metabolic syndrome when administered at a dose of 21 mg/kg to the fructose (60%)-fed rat (a model of metabolic syndrome). In the present work, we analyzed on the same model the effect of pure polyphenolic molecules (catechin, resveratrol, delphinidin, and gallic acid) administered at a dose of 2.1 mg/kg. Delphinidin and gallic acid prevented insulin resistance, while gallic acid prevented the elevation of blood pressure. All molecules prevented cardiac ROS overproduction and NADPH overexpression. We also showed that fructose feeding was associated with cardiac fibrosis (accumulation of collagen 1) and expression of osteopontin, a factor induced by ROS and a collagen I expression inducer. Collagen I and osteopontin expressions were prevented by the administration of all polyphenolic molecules. The potential use of polyphenols in the prevention of cardiac fibrosis should be further explored.
C1 [Oiry, Catherine; Azay-Milhau, Jacqueline; Youl, Estelle; Magous, Richard; Cros, Gerard] Univ Montpellier I, CPID, F-34093 Montpellier 5, France.
   [Sutra, Thibault; Cristol, Jean-Paul] Univ Montpellier I, Inst Univ Rech Clin Nutr Humaine Biodisponibilite, EA 4188, F-34093 Montpellier 5, France.
   [Oiry, Catherine; Azay-Milhau, Jacqueline; Youl, Estelle; Magous, Richard; Cros, Gerard] CNRS, UMR 5232, Montpellier, France.
   [Teissedre, Pierre-Louis] Univ Bordeaux 2, Fac Oenol, UMR 1219, ISVV,Lab Chim Appl, F-33405 Talence, France.
C3 Universite de Montpellier; Universite de Montpellier; Centre National de
   la Recherche Scientifique (CNRS); Universite de Bordeaux; Institut
   National de la Sante et de la Recherche Medicale (Inserm)
RP Cros, G (corresponding author), Univ Montpellier I, CPID, F-34093 Montpellier 5, France.
EM gerard.cros@univ-montp1.fr
RI Teissedre, Pierre-Louis/I-6885-2016
OI TEISSEDRE, Pierre-Louis/0000-0002-0115-5456; Azay-Milhau,
   Jacqueline/0000-0001-9965-9996; , Jean-Paul Cristol/0000-0001-8563-7278;
   Youl, Estella/0000-0002-0185-0846
FU French Minister of Agriculture (ONIVINS)
FX The authors thank the financial support of the French Minister of
   Agriculture (ONIVINS).
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NR 27
TC 29
Z9 30
U1 0
U2 7
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0021-8561
EI 1520-5118
J9 J AGR FOOD CHEM
JI J. Agric. Food Chem.
PD DEC 24
PY 2008
VL 56
IS 24
BP 11683
EP 11687
DI 10.1021/jf802357g
PG 5
WC Agriculture, Multidisciplinary; Chemistry, Applied; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture; Chemistry; Food Science & Technology
GA 385GJ
UT WOS:000261802400019
PM 19049292
DA 2025-06-11
ER

PT J
AU Paz-Graniel, I
   Babio, N
   Nishi, SK
   Martínez-González, MA
   Corella, D
   Fitó, M
   Martínez, A
   Alonso-Gómez, AM
   Wärnberg, J
   Vioque, J
   Romaguera, D
   López-Miranda, J
   Estruch, R
   Tinahones, FJ
   Santos-Lozano, JM
   Serra-Majem, JL
   Bueno-Cavanillas, A
   Tur, JA
   Sánchez, VM
   Pintó, X
   Delgado-Rodríguez, M
   Matía-Martín, P
   Vidal, J
   Calderon-Sanchez, C
   Daimiel, L
   Ros, E
   Fernández-Aranda, F
   Toledo, E
   Valle-Hita, C
   Sorli, JV
   Lassale, C
   Garcia-Rios, A
   Oncina-Canovas, A
   Barón-Lopez, FJ
   Zulet, MA
   Rayó, E
   Casas, R
   Thomas-Carazo, E
   Tojal-Sierra, L
   Damas-Fuentes, M
   Ruiz-Canela, M
   de las Heras-delgado, S
   Fernandez-Carrión, R
   Castañer, O
   Peña-Orihuela, PJ
   Gonzalez-Palacios, S
   Buil-Cosiales, P
   Goday, A
   Salas-Salvadó, J
AF Paz-Graniel, Indira
   Babio, Nancy
   Nishi, Stephanie K.
   Martinez-Gonzalez, Miguel angel
   Corella, Dolores
   Fito, Montserrat
   Martinez, Alfredo
   Alonso-Gomez, angel M.
   Waernberg, Julia
   Vioque, Jesus
   Romaguera, Dora
   Lopez-Miranda, Jose
   Estruch, Ramon
   Tinahones, Francisco J.
   Santos-Lozano, Jose Manuel
   Serra-Majem, J. Luis
   Bueno-Cavanillas, Aurora
   Tur, Josep A.
   Sanchez, Vicente Martin
   Pinto, Xavier
   Delgado-Rodriguez, Miguel
   Matia-Martin, Pilar
   Vidal, Josep
   Calderon-Sanchez, Cristina
   Daimiel, Lidia
   Ros, Emili
   Fernandez-Aranda, Fernando
   Toledo, Estefania
   Valle-Hita, Cristina
   Sorli, Jose V.
   Lassale, Camille
   Garcia-Rios, Antonio
   Oncina-Canovas, Alejandro
   Baron-Lopez, Francisco Javier
   Zulet, M. Angeles
   Rayo, Elena
   Casas, Rosa
   Thomas-Carazo, Esther
   Tojal-Sierra, Lucas
   Damas-Fuentes, Miguel
   Ruiz-Canela, Miguel
   de las Heras-delgado, Sara
   Fernandez-Carrion, Rebeca
   Castaner, Olga
   Pena-Orihuela, Patricia J.
   Gonzalez-Palacios, Sandra
   Buil-Cosiales, Pilar
   Goday, Albert
   Salas-Salvado, Jordi
TI How Did the COVID-19 Lockdown Pandemic Affect the Depression
   Symptomatology in Mediterranean Older Adults with Metabolic Syndrome?
SO DEPRESSION AND ANXIETY
LA English
DT Article
AB Background and Aims. To control the COVID-19 spread, in March 2020, a forced home lockdown was established in Spain. In the present study, we aimed to assess the effect of mobility and social COVID-19-established restrictions on depressive symptomatology in older adults with metabolic syndrome. We hypothesize that severe restrictions might have resulted in detrimental changes in depressive symptomatology.
   Methods. 2,312 PREDIMED-Plus study participants (men = 53:9%; mean age = 64:9 +/- 4:8 years) who completed a COVID-19 lockdown questionnaire to assess the severity of restrictions/lockdown and the validated Spanish version of the Beck Depression Inventory-II (BDI-II) during the three established phases concerning the COVID-19 lockdown in Spain (prelockdown, lockdown, and postlockdown) were included in this longitudinal analysis. Participants were categorized according to high or low lockdown severity. Analyses of covariance were performed to assess changes in depressive symptomatology across lockdown phases.
   Results. No significant differences in participant depression symptomatology changes were observed between lockdown severity categories (low/high) at the studied phases. During the lockdown phase, participants showed a decrease in BDI-II score compared to the prelockdown phase (mean (95% CI), -0.48 (-0.24, -0.72), P < 0:001); a nonsignificantly larger decrease was observed in participants allocated in the low-lockdown category (low: -0.59 (-0.95, -0.23), high: -0.43 (-0.67, -0.19)). Similar decreases in depression symptomatology were found for the physical environment dimension. The post- and prelockdown phase BDI-II scores were roughly similar.
   Conclusions. The COVID-19 pandemic lockdown was associated with a decrease in depressive symptomatology that returned to prelockdown levels after the lockdown. The degree of lockdown was not associated with depressive symptomatology. The potential preventive role of the physical environment and social interactions on mental disorders during forced home lockdown should be further studied. This trial is registered with ISRCTN89898870. Retrospectively registered on 24 July 2014.
C1 [Paz-Graniel, Indira; Babio, Nancy; Nishi, Stephanie K.; Martinez-Gonzalez, Miguel angel; Corella, Dolores; Fito, Montserrat; Martinez, Alfredo; Alonso-Gomez, angel M.; Waernberg, Julia; Romaguera, Dora; Lopez-Miranda, Jose; Estruch, Ramon; Tinahones, Francisco J.; Santos-Lozano, Jose Manuel; Serra-Majem, J. Luis; Tur, Josep A.; Pinto, Xavier; Daimiel, Lidia; Ros, Emili; Fernandez-Aranda, Fernando; Toledo, Estefania; Valle-Hita, Cristina; Sorli, Jose V.; Lassale, Camille; Garcia-Rios, Antonio; Baron-Lopez, Francisco Javier; Zulet, M. Angeles; Casas, Rosa; Tojal-Sierra, Lucas; Damas-Fuentes, Miguel; Ruiz-Canela, Miguel; de las Heras-delgado, Sara; Fernandez-Carrion, Rebeca; Castaner, Olga; Pena-Orihuela, Patricia J.; Buil-Cosiales, Pilar; Goday, Albert; Salas-Salvado, Jordi] Inst Salud Carlos III, CIBER Fisiopatol Obes & Nutr, Madrid, Spain.
   [Paz-Graniel, Indira; Babio, Nancy; Nishi, Stephanie K.; Valle-Hita, Cristina; de las Heras-delgado, Sara; Salas-Salvado, Jordi] Univ Rovira & Virgili, Dept Bioquim & Biotecnol, Unitat Nutricio, Reus, Spain.
   [Paz-Graniel, Indira; Babio, Nancy; Nishi, Stephanie K.; Valle-Hita, Cristina; de las Heras-delgado, Sara; Salas-Salvado, Jordi] Inst Invest Sanit Pere Virgili IISPV, Reus, Spain.
   [Nishi, Stephanie K.] Toronto Diet 3D Digest Tract & Dis Knowledge Synth, Toronto, ON, Canada.
   [Nishi, Stephanie K.] St Michaels Hosp, Clin Nutr & Risk Factor Modificat Ctr, Unity Hlth Toronto, Toronto, ON, Canada.
   [Martinez-Gonzalez, Miguel angel; Toledo, Estefania; Ruiz-Canela, Miguel] Univ Navarra, Dept Prevent Med & Publ Hlth, IDISNA, Pamplona, Spain.
   [Martinez-Gonzalez, Miguel angel] Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA.
   [Corella, Dolores; Sorli, Jose V.; Fernandez-Carrion, Rebeca] Univ Valencia, Dept Prevent Med, Valencia, Spain.
   [Fito, Montserrat; Lassale, Camille; Castaner, Olga; Goday, Albert] Inst Hosp Mar Invest Med Municipal Invest Med IMIM, Unit Cardiovasc Risk & Nutr, Barcelona, Spain.
   [Martinez, Alfredo; Zulet, M. Angeles] Univ Navarra, Ctr Nutr Res, Dept Nutr Food Sci & Physiol, Pamplona, Spain.
   [Martinez, Alfredo; Zulet, M. Angeles; Buil-Cosiales, Pilar] Navarra Inst Hlth Res IdisNA, Pamplona 31008, Spain.
   [Martinez, Alfredo; Alonso-Gomez, angel M.; Tojal-Sierra, Lucas] Bioaraba Hlth Res Inst, Cardiovasc Resp & Metab Area, Vitoria, Spain.
   [Corella, Dolores; Alonso-Gomez, angel M.; Tojal-Sierra, Lucas] Araba Univ Hosp, Osakidetza Basque Hlth Serv, Vitoria-gasteiz, Spain.
   [Alonso-Gomez, angel M.; Sanchez, Vicente Martin; Tojal-Sierra, Lucas] Univ Basque Country UPV EHU, Vitoria, Spain.
   [Waernberg, Julia] Univ Malaga, Sch Hlth Sci, EpiPHAAN Res Grp, Inst Invest Biomed Malaga IBIMA, Malaga, Spain.
   [Vioque, Jesus; Bueno-Cavanillas, Aurora] Inst Salud Carlos III, CIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain.
   [Vioque, Jesus] Univ Miguel Hernandez, Inst Invest Sanit & Biomed Alicante, ISABIAL UMH, Alicante 03550, Spain.
   [Romaguera, Dora] Hlth Res Inst Balear Isl IdISBa, Palma De Mallorca, Spain.
   [Lopez-Miranda, Jose] Univ Cordoba, Reina Sofia Univ Hosp, Maimonides Biomed Res Inst Cordoba IMIB, Dept Internal Med, Cordoba, Spain.
   [Estruch, Ramon] Univ Barcelona, Hosp Clin, Inst Invest Biomed August Pi Sunyer IDIBAPS, Dept Internal Med, Barcelona, Spain.
   [Estruch, Ramon] Univ Barcelona, Inst Recerca Nutr & Seguretat Alimentaria INSA UB, Barcelona, Spain.
   [Tinahones, Francisco J.] Univ Malaga, Virgen Victoria Hosp, Dept Endocrinol, Inst Invest Biomed Malaga IBIMA, Malaga, Spain.
   [Santos-Lozano, Jose Manuel] Dist Sanit Atenc Primaria Sevilla, Dept Family Med, Res Unit, Seville, Spain.
   [Serra-Majem, J. Luis] Univ Palmas Gran Canaria, Ctr Hosp Univ Insular Materno Infantil CHUIMI, Res Inst Biomed & Hlth Sci IUIBS, Canarian Hlth Serv, Las Palmas Gran Canaria, Spain.
   [Bueno-Cavanillas, Aurora] Univ Granada, Dept Prevent Med & Publ Hlth, Granada, Spain.
   [Tur, Josep A.] Univ Balear Isl, Res Grp Community Nutr & Oxidat Stress, Palma De Mallorca, Spain.
   [Sanchez, Vicente Martin] Univ Leon, Inst Biomed IBIOMED, Leon, Spain.
   [Pinto, Xavier] Hosp Univ Bellvitge, Lipids & Vasc Risk Unit, Internal Med, IDIBELL, Barcelona, Spain.
   [Pinto, Xavier] Univ Barcelona, Sch Med & Hlth Sci, Dept Clin Sci, Barcelona 08907, Spain.
   [Delgado-Rodriguez, Miguel] Univ Jaen, Inst Univ Invest Olivar & Aceites Ol INUO, Fac Med, Div Prevent Med, Jaen, Spain.
   [Matia-Martin, Pilar] Univ Complutense, Inst Invest Sanit Hosp Clin San Carlos IdISSC, Dept Endocrinol & Nutr, Madrid, Spain.
   [Vidal, Josep] Inst Salud Carlos III ISCIII, CIBER Diabet & Enfermedades Metab CIBERDEM, Madrid, Spain.
   [Vidal, Josep] Univ Barcelona, Hosp Clin, Inst Invest Biomed August Pi Sunyer IDIBAPS, Dept Endocrinol, Barcelona, Spain.
   [Calderon-Sanchez, Cristina] Univ Autonoma, Hosp Fdn Jimenez Diaz, Dept Endocrinol & Nutr, Inst Invest Biomed IISFJD, Madrid, Spain.
   [Daimiel, Lidia] CEI UAM CSIC, Precis Nutr & Obes Program, Nutr Control Epigenome Grp, IMDEA Food, Madrid, Spain.
   [Ros, Emili] Hosp Clin Barcelona, Inst Invest Biomed August Pi Sunyer IDIBAPS, Dept Endocrinol & Nutr, Lipid Clin, Barcelona, Spain.
   [Fernandez-Aranda, Fernando] Inst Invest Biomed Bellvitge IDIBELL, Psychoneurobiol Eating & Addict Behav Grp, Barcelona 08907, Spain.
   [Fernandez-Aranda, Fernando] Univ Hosp Bellvitge, Clin Psychol Unit, Barcelona 08907, Spain.
   [Lassale, Camille] Univ Pompeu Fabra UPF, Dept Med & Life Sci, Barcelona 08003, Spain.
   [Thomas-Carazo, Esther] Ctr Salud Gran Capitan, Serv Andaluz Salud, Granada, Andorra.
   [Buil-Cosiales, Pilar] Serv Navarro Salud, Atenc Primaria, Navarra, Spain.
C3 CIBER - Centro de Investigacion Biomedica en Red; CIBEROBN; Instituto de
   Salud Carlos III; Universitat Rovira i Virgili; University of Toronto;
   Saint Michaels Hospital Toronto; University of Navarra; Harvard
   University; Harvard T.H. Chan School of Public Health; University of
   Valencia; University of Navarra; University of Navarra; Bioaraba Health
   Research Institute; University Hospital of Araba; University of Basque
   Country; Instituto de Investigacion Biomedica de Malaga y Plataforma en
   Nanomedicina (IBIMA); Universidad de Malaga; Instituto de Salud Carlos
   III; CIBER - Centro de Investigacion Biomedica en Red; CIBERESP; General
   University Hospital of Alicante; Universidad Miguel Hernandez de Elche;
   Universitat d'Alacant; Instituto de Investigacion Sanitaria y Biomedica
   de Alicante (ISABIAL); Institut Investigacio Sanitaria Illes Balears
   (IdISBa); Universidad de Cordoba; University of Barcelona; Hospital
   Clinic de Barcelona; IDIBAPS; University of Barcelona; Instituto de
   Investigacion Biomedica de Malaga y Plataforma en Nanomedicina (IBIMA);
   Universidad de Malaga; Universidad de Las Palmas de Gran Canaria;
   University of Granada; Universitat de les Illes Balears; Universidad de
   Leon; University of Barcelona; Institut d'Investigacio Biomedica de
   Bellvitge (IDIBELL); Bellvitge University Hospital; University of
   Barcelona; Universidad de Jaen; Complutense University of Madrid; CIBER
   - Centro de Investigacion Biomedica en Red; CIBERDEM; University of
   Barcelona; Hospital Clinic de Barcelona; IDIBAPS; Autonomous University
   of Madrid; Fundacion Jimenez Diaz; IMDEA Food Institute; Consejo
   Superior de Investigaciones Cientificas (CSIC); University of Barcelona;
   Hospital Clinic de Barcelona; IDIBAPS; Institut d'Investigacio Biomedica
   de Bellvitge (IDIBELL); University of Barcelona; Institut d'Investigacio
   Biomedica de Bellvitge (IDIBELL); Bellvitge University Hospital; Pompeu
   Fabra University; Servicio Navarro de Salud - Osasunbidea
RP Salas-Salvadó, J (corresponding author), Inst Salud Carlos III, CIBER Fisiopatol Obes & Nutr, Madrid, Spain.; Salas-Salvadó, J (corresponding author), Univ Rovira & Virgili, Dept Bioquim & Biotecnol, Unitat Nutricio, Reus, Spain.; Salas-Salvadó, J (corresponding author), Inst Invest Sanit Pere Virgili IISPV, Reus, Spain.
EM indiradelsocorro.paz@urv.cat; nancy.babio@urv.cat;
   stephanie.nishi@urv.cat; mamartinez@unav.es; dolores.corella@uv.es;
   mfito@imim.es; jalfmtz@unav.es; angelmago13@gmail.com; jwarnberg@uma.es;
   vioque@umh.es; dora.romaguera@isglobal.org; md1lomij@uco.es;
   restruch@clinic.cat; fjtinahones@hotmail.com;
   josemanuel.santos.lozano@gmail.com; lluis.serra@ulpgc.es; abueno@ugr.es;
   pep.tur@uib.es; vicente.martin@unileon.es; xpinto@bellvitgehospital.cat;
   mdelgado@ujaen.es; pilar.matia@gmail.com; jovidal@clinic.cat;
   cristina.calderon@fjd.es; lidia.daimiel@imdea.org; eros@clinic.cat;
   ffernandez@bellvitgehospital.cat; etoledo@unav.es;
   cristina.valle@urv.cat; sorli@uv.es; classale@imim.es;
   angarios2004@yahoo.es; aoncina@umh.es; baron@uma.es; mazulet@unav.es;
   elena.rayo@ssib.es; rcasas1@recerca.clinic.cat; estherthca@gmail.com;
   lutojal@hotmail.com; migueldamasf@hotmail.com; mcanela@unav.es;
   sara.delasheras@estudiants.urv.cat; rebeca.fernandez@uv.es;
   ocastaner@imim.es; patricia.pena@imibic.org; sandra.gonzalezp@umh.es;
   pilarbuilc@gmail.com; agoday@psmar.cat; jordi.salas@urv.cat
RI Tejada, Silvia/L-7297-2014; Palacios, Sandra/AAA-9585-2021; Vioque,
   Jesus/A-1066-2008; Ruiz-Canela, Miguel/JYP-1794-2024; Lopez-Miranda,
   Jose/Y-8306-2019; Vidal, Josep/MIK-6936-2025; Daimiel-Ruiz,
   Lidia/M-7779-2014; Lassale, Camille/ABE-7813-2020; Pintó,
   Xavier/AGI-4297-2022; Castaner, Olga/F-1533-2013; Tur,
   Josep/AAE-5748-2020; Rodríguez, Miguel/KCZ-1828-2024; Paz-Graniel,
   Indira/ABH-2583-2020; Fernandez-Carrion, Rebeca/AAA-5713-2019; López,
   Francisco/O-9249-2016; Bueno-Cavanillas, Aurora/O-1513-2015; Babio,
   Nancy/AAN-2715-2020; Tinahones, Francisco/AAB-2882-2020; Oncina Canovas,
   Alejandro/KOD-0906-2024; Toledo, Estefania/H-6211-2014; ALONSO GOMEZ,
   ANGEL/HLG-2476-2023; Zulet, M./H-1317-2017; Martinez-Gonzalez,
   Miguel/AAE-7669-2019; Sorlí, José/L-8758-2014; Serra-Majem,
   Lluis/I-6708-2019; Estruch, Ramon/AAZ-3723-2020; Romaguera,
   Dora/ABE-7004-2020; Corella, Dolores/L-9888-2014; Martínez,
   J./K-8709-2014; Nishi, Stephanie/GSN-1143-2022; Casas,
   Rosa/ABD-1915-2020; Fito Colomer, Montse/C-1822-2012; Martin,
   Vicente/A-1597-2008; FERNANDEZ-ARANDA, FERNANDO/L-9762-2014;
   Salas-Salvado, Jordi/C-7229-2017
OI Fito Colomer, Montse/0000-0002-1817-483X; Martin,
   Vicente/0000-0003-0552-2804; Nishi, Stephanie/0000-0002-7878-5368;
   Oncina Canovas, Alejandro/0000-0003-4652-0565; Lassale,
   Camille/0000-0002-9340-2708; Tinahones, Francisco J/0000-0001-6871-4403;
   FERNANDEZ-ARANDA, FERNANDO/0000-0002-2968-9898; BABIO SANCHEZ,
   NANCY/0000-0003-3527-5277; Salas-Salvado, Jordi/0000-0003-2700-7459;
   Sorli, Jose V/0000-0002-0130-2006; Lopez-Miranda,
   Jose/0000-0002-8844-0718; Paz Graniel, Indira/0000-0002-3204-6877; Valle
   Hita, Cristina/0000-0001-5423-7466; de las Heras Delgado,
   Sara/0000-0002-3439-5712
FU European Regional Development Fund [PI13/00673, PI13/00492, PI13/00272,
   PI13/01123, PI13/00462, PI13/00233, PI13/02184, PI13/00728, PI13/01090,
   PI13/01056, PI14/01722, PI14/00636, PI14/00618, PI14/00696, PI14/01206,
   PI14/01919, PI14/00853, PI14/01374, PI14/00972, PI14/00728, PI14/01471];
   European Research Council [340918]; Recercaixa [2013ACUP00194];
   Consejeria de Salud de la Junta de Andalucia [PI0458/2013, PS0358/2016,
   PI0137/2018]; Junta de Andalucia [MFE-171207]; Department of Health of
   the Junta de Andalucia; ICREA; CIBER Fisiopatologia de la Obesidad y
   Nutricion (CIBEROBN); MICIN/AEI/FEDER, UE; Instituto de Salud Carlos III
   (ISCIII), through the Fondo de Investigacion para la Salud (FIS)
   [SLT006/17/00246]; Canadian Institutes of Health Research (CIHR);
   Especial Action Project entitled: Implementacion y evaluacion de una
   intervencion intensiva sobre la actividad fisica Cohorte PREDIMED-Plus
   [CEX2021-001234-M]; Generalitat de Catalunya; Fundacion Francisco Soria
   Melguizo
FX This work was supported by the official Spanish Institutions for funding
   scientific biomedical research, CIBER Fisiopatologia de la Obesidad y
   Nutricion (CIBEROBN) and Instituto de Salud Carlos III (ISCIII), through
   the Fondo de Investigacion para la Salud (FIS), which is cofunded by the
   European Regional Development Fund (six coordinated FIS projects led by
   JS-S and JVi, including the following projects: PI13/00673, PI13/00492,
   PI13/00272, PI13/01123, PI13/00462, PI13/00233, PI13/02184, PI13/00728,
   PI13/01090, PI13/01056, PI14/01722, PI14/00636, PI14/00618, PI14/00696,
   PI14/01206, PI14/01919, PI14/00853, PI14/01374, PI14/00972, PI14/00728,
   PI14/01471, PI16/00473, PI16/00662, PI16/01873, PI16/01094, PI16/00501,
   PI16/00533, PI16/00381, PI16/00366, PI16/01522, PI16/01120, PI17/00764,
   PI17/01183, PI17/00855, PI17/01347, PI17/00525, PI17/01827, PI17/00532,
   PI17/00215, PI17/01441, PI17/00508, PI17/01732, PI17/00926, PI19/00957,
   PI19/00386, PI19/00309, PI19/01032, PI19/00576, PI19/00017, PI19/01226,
   PI19/00781, PI19/01560, PI19/01332, PI20/01802, PI20/00138, PI20/01532,
   PI20/00456, PI20/00339, PI20/00557, PI20/00886, PI20/01158); the
   Especial Action Project entitled: Implementacion y evaluacion de una
   intervencion intensiva sobre la actividad fisica Cohorte PREDIMED-Plus
   grant to JS-S; the European Research Council (Advanced Research Grant
   2014-2019; agreement #340918) granted to MAM-G.; the Recercaixa (number
   2013ACUP00194) grant to JS-S; grants from the Consejeria de Salud de la
   Junta de Andalucia (PI0458/2013, PS0358/2016, PI0137/2018); the
   PROMETEO/2017/017 grant from the Junta de Andalucia; the SEMERGEN grant
   and funds from the Junta de Andalucia (CB06/03). Study resulting from
   the SLT006/17/00246 grant, funded by the Department of Health of the
   Junta de Andalucia by the call "Accio instrumental de programes de
   recerca orientats en l'ambit de la recerca i la innovacio en salut." We
   thank the CERCA Programme/Generalitat de Catalunya for their
   institutional support. We thank Fundacion Francisco Soria Melguizo for
   the financial support. Jordi Salas-Salvado is partially supported by
   ICREA under the ICREA Academia program. The Institut de Recerca en
   Nutricio i Seguretat Alimentaria (INSA-UB), University of Barcelona,
   Barcelona, Spain, is recognized as a Maria de Maeztu Unit of Excellence
   grant CEX2021-001234-M) funded by MICIN/AEI/FEDER, UE. S.K.N. is
   supported by a postdoctoral fellowship from the Canadian Institutes of
   Health Research (CIHR, MFE-171207). C.V-H. receives a predoctoral grant
   from the Generalitat de Catalunya (2022 FI_B100108).
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   World Health Organization, 2017, WHOMSDMER20172
   World Health Organization, 2022, Azov Media
NR 26
TC 1
Z9 1
U1 1
U2 14
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1091-4269
EI 1520-6394
J9 DEPRESS ANXIETY
JI Depress. Anxiety
PD JUL 14
PY 2023
VL 2023
AR 6765950
DI 10.1155/2023/6765950
PG 9
WC Psychology, Clinical; Psychiatry; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA N1GX8
UT WOS:001034593000001
PM 40224603
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Xiao, LH
   Sun, Y
   Tsao, R
AF Xiao, Lihua
   Sun, Yong
   Tsao, Rong
TI Paradigm Shift in Phytochemicals Research: Evolution from Antioxidant
   Capacity to Anti-Inflammatory Effect and to Roles in Gut Health and
   Metabolic Syndrome
SO JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
LA English
DT Article
DE food bioactives; phytochemicals; polyphenolics; carotenoids;
   antioxidant; anti-inflammation; gut microbiota; immune response;
   metabolic syndrome
ID NF-KAPPA-B; CHAIN FATTY-ACIDS; LOW-GRADE INFLAMMATION; VULGA L. MILK;
   OXIDATIVE STRESS; IN-VITRO; PHENOLIC-COMPOUNDS; POLYPHENOL METABOLITES;
   NATURAL-PRODUCTS; ADIPOSE-TISSUE
AB Food bioactive components, particularly phytochemicals with antioxidant capacity, have been extensively studied over the past two decades. However, as new analytical and molecular biological tools advance, antioxidants related research has undergone significant paradigm shifts. This review is a high-level overview of the evolution of phytochemical antioxidants research. Early research used chemical models to assess the antioxidant capacity of different phytochemicals, which provided important information about the health potential, but the results were overused and misinterpreted despite the lack of biological relevance (Antioxidants v1.0). This led to findings in the anti-inflammatory properties and modulatory effects of cell signaling of phytochemicals (Antioxidants v2.0). Recent advances in the role of diet in modulating gut microbiota have suggested a new phase of food bioactives research along the phytochemicals-gut microbiota-intestinal metabolites-low-grade inflammation-metabolic syndrome axis (Antioxidants v3.0). Polyphenols and carotenoids were discussed in-depth, and future research directions were also
C1 [Xiao, Lihua; Sun, Yong] Nanchang Univ, State Key Lab Food Sci & Technol, Nanchang 330047, Jiangxi, Peoples R China.
   [Tsao, Rong] Agr & Agrifood Canada, Guelph Res & Dev Ctr, Guelph, ON N1G 5C9, Canada.
C3 Nanchang University; Agriculture & Agri Food Canada
RP Tsao, R (corresponding author), Agr & Agrifood Canada, Guelph Res & Dev Ctr, Guelph, ON N1G 5C9, Canada.
EM Rong.Cao@agr.gc.ca
RI Tsao, Rong/I-3096-2014
OI Sun, Yong/0000-0003-2324-7180; Tsao, Rong/0000-0001-6537-1820; Xiao,
   Lihua/0009-0003-5514-452X
FU Agriculture & Agri-Food Canada [J-002252]; National Natural Science
   Foundation of China [82060781]; China Postdoctoral Science Foundation
   [2020M671975]
FX This study was supported by the A-Base project (#J-002252) of
   Agriculture & Agri-Food Canada, the National Natural Science Foundation
   of China (No. 82060781) , and the China Postdoctoral Science Foundation
   (No. 2020M671975) .
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NR 180
TC 22
Z9 22
U1 2
U2 51
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0021-8561
EI 1520-5118
J9 J AGR FOOD CHEM
JI J. Agric. Food Chem.
PD JUL 20
PY 2022
VL 70
IS 28
BP 8551
EP 8568
DI 10.1021/acs.jafc.2c02326
EA JUL 2022
PG 18
WC Agriculture, Multidisciplinary; Chemistry, Applied; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture; Chemistry; Food Science & Technology
GA 3D8CP
UT WOS:000829233000001
PM 35793510
DA 2025-06-11
ER

PT J
AU Lin, CH
   Chiang, SL
   Heitkemper, MM
   Hung, YJ
   Lee, MS
   Tzeng, WC
   Chiang, LC
AF Lin, Chia-Huei
   Chiang, Shang-Lin
   Heitkemper, Margaret McLean
   Hung, Yi-Jen
   Lee, Meei-Shyuan
   Tzeng, Wen-Chii
   Chiang, Li-Chi
TI Effects of telephone-based motivational interviewing in lifestyle
   modification program on reducing metabolic risks in middle-aged and
   older women with metabolic syndrome: A randomized controlled trial
SO INTERNATIONAL JOURNAL OF NURSING STUDIES
LA English
DT Article
DE Lifestyle modification; Metabolic syndrome; Motivational interviewing;
   Physical activity; Randomized controlled trial; Telephone; Women
ID PROMOTE PHYSICAL-ACTIVITY; ACTIVITY INTERVENTION; OXIDATIVE STRESS;
   NATIONAL-HEALTH; PREVALENCE; EXERCISE; ADULTS; METAANALYSIS; POPULATION;
   DIET
AB Background: Lifestyle modification is often difficult for middle-aged and older women living in the community who are at high risk of physical inactivity and metabolic syndrome.
   Objectives: To examine the effects of telephone-based motivational interviewing in a 12-week lifestyle modification program on physical activity, MetS, metabolic risks (fasting plasma glucose, blood pressure, triglyceride, high-density lipoprotein, and central obesity), and the number of metabolic risks in community-living middle-aged and older women diagnosed with metabolic syndrome.
   Research design and method: A randomized controlled trial was conducted. Recruited were 328 middle-aged and older women from a community health center in Taiwan. Eligible women medically diagnosed with metabolic syndrome (n = 115) were randomly assigned to one of three groups: The experimental group received an individualized telephone delivered lifestyle modification program that included motivational interviewing delivered by an experienced nurse. The brief group received a single brief lifestyle modification counseling session with a brochure. The usual care group received standard care. Physical activity was assessed with the International Physical Activity Questionnaire and metabolic risks were determined by serum markers and anthropometric measures at pre- and post-intervention. One hundred women completed the study and an intention-to treat analysis was performed. Generalized estimating equations were used to examine the intervention effects.
   Results: Women in the experimental group increased physical activity from 1609 to 1892 MET-min/week (beta=846, p=.01), reduced the percentage of diagnosed with metabolic syndrome to 81.6% (beta=-0.17, p=.003), and decreased the number of metabolic risks from 4.0 to 3.6 (beta=-0.50, p<.001), compared to the usual care group (4.4-4.6). There was not a reduction in the percentage of diagnosed with metabolic syndrome in the brief group, but they had fewer metabolic risks after 12 weeks (mean=4.0 vs. 4.6, (beta=-0.2, p=.02) compared to the usual care group.
   Conclusions: Motivational interviewing as a component of an individualized physical activity and lifestyle modification program has positive benefit in reducing metabolic risks in middle-aged and older women. (C) 2016 Elsevier Ltd. All rights reserved.
C1 [Lin, Chia-Huei] Natl Def Med Ctr, Sch Nursing, Triserv Gen Hosp, Dept Nursing, Taipei, Taiwan.
   [Chiang, Shang-Lin] Natl Def Med Ctr, Sch Med, Triserv Gen Hosp, Dept Phys Med & Rehabil, Taipei, Taiwan.
   [Heitkemper, Margaret McLean] Univ Washington, Sch Med, Div Gastroenterol, Dept Biobehav Nursing & Hlth Syst, Seattle, WA 98195 USA.
   [Hung, Yi-Jen] Natl Def Med Ctr, Sch Med, Triserv Gen Hosp, Div Endocrinol & Metab, Taipei, Taiwan.
   [Lee, Meei-Shyuan] Natl Def Med Ctr, Sch Publ Hlth, Taipei, Taiwan.
   [Lee, Meei-Shyuan; Chiang, Li-Chi] Natl Def Med Ctr, Grad Inst Med Sci, Taipei, Taiwan.
   [Tzeng, Wen-Chii; Chiang, Li-Chi] Natl Def Med Ctr, Sch Nursing, Taipei, Taiwan.
   [Chiang, Li-Chi] China Med Univ, Taipei, Taiwan.
   [Chiang, Li-Chi] Natl Def Med Ctr, Sch Nursing, Taichung, Taiwan.
   [Chiang, Li-Chi] Natl Def Med Ctr, Grad Inst Med Sci, Taichung, Taiwan.
   [Chiang, Li-Chi] China Med Univ, Taichung, Taiwan.
C3 Tri-Service General Hospital; National Defense Medical Center;
   Tri-Service General Hospital; National Defense Medical Center;
   University of Washington; University of Washington Seattle; Tri-Service
   General Hospital; National Defense Medical Center; National Defense
   Medical Center; National Defense Medical Center; National Defense
   Medical Center; China Medical University Taiwan; National Defense
   Medical Center; National Defense Medical Center; China Medical
   University Taiwan
RP Chiang, LC (corresponding author), Sch Nursing, 161 Sec 6,Mingchuan E Rd, Taipei 114, Taiwan.
EM lichichiang@gmail.com
RI Lin, Chia-Huei/GLQ-5499-2022; Tzeng, Wen-Chii/M-4214-2014; Chiang,
   Li-Chi/AAW-9661-2020
OI Tzeng, Wen-Chii/0000-0002-4205-896X; Lin, Chia-Huei/0000-0002-5557-9668;
   Chiang, Li-Chi/0000-0002-6383-7495; Lin, Chia-Huei/0000-0003-3751-602X
FU Tri-Service General Hospital, Taipei, Taiwan [TSGH-C102-138]
FX This study was funded by the Tri-Service General Hospital
   (TSGH-C102-138), Taipei, Taiwan.
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NR 57
TC 38
Z9 43
U1 4
U2 32
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0020-7489
EI 1873-491X
J9 INT J NURS STUD
JI Int. J. Nurs. Stud.
PD AUG
PY 2016
VL 60
BP 12
EP 23
DI 10.1016/j.ijnurstu.2016.03.003
PG 12
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA DQ3KZ
UT WOS:000379102500002
PM 27297365
DA 2025-06-11
ER

PT J
AU Muhic, E
   Mathiesen, S
   Nielsen, MM
   Suominen, A
   Sorensen, K
   Ifversen, M
   Nolsöe, RL
   Pedersen, KM
   Lähteenmäki, P
   Nordestgaard, BG
   Juul, A
   Jahnukainen, K
   Müller, K
AF Muhic, Ena
   Mathiesen, Sidsel
   Nielsen, Malene Mejdahl
   Suominen, Anu
   Sorensen, Kaspar
   Ifversen, Marianne
   Nolsoe, Runa Louise
   Pedersen, Kasper Monsted
   Lahteenmaki, Paivi
   Nordestgaard, Borge Gronne
   Juul, Anders
   Jahnukainen, Kirsi
   Muller, Klaus
TI Metabolic Syndrome in Male Survivors of Pediatric Allogeneic
   Hematopoietic Stem Cell Transplantation: Impact of Total Body
   Irradiation, Low-Grade Inflammation, and Hypogonadism
SO TRANSPLANTATION AND CELLULAR THERAPY
LA English
DT Article
DE Hematopoietic stem cell transplantation; Late effects; Long-term
   survivors; Metabolic syndrome; Pediatrics
ID BONE-MARROW-TRANSPLANTATION; IMPAIRED GLUCOSE-TOLERANCE;
   DIABETES-MELLITUS; CHILDHOOD-CANCER; LONG-TERM; ENDOCRINE; RISK;
   PREVALENCE; DIAGNOSIS; CHILDREN
AB Metabolic syndrome (MetS) is a growing concern in survivors of pediatric hematopoietic stem cell transplantation (HSCT), but little is known about the underlying mechanisms. This study aimed to determine the prevalence and clinical presentation of MetS in male long-term survivors of pediatric HSCT and to investigate predisposing factors, including low-grade inflammation, altered fat distribution, and low testosterone levels. We included 98 survivors age 19 to 47 years at a median follow-up of 18 years (range, 8 to 35 years) after pediatric HSCT. MetS was defined according to the National Cholesterol Education Program Adult Treatment Panel III criteria. The prevalence and clinical manifestations of MetS were compared between our cohort and a control group of males from the background population (n = 4767). Fat distribution was assessed by android/gynoid ratio from a whole-body dual-energy X-ray absorptiometry scan. Systemic inflammation was evaluated by IL-6 and high-sensitivity C-reactive protein (hsCRP). Serum testosterone levels were measured in morning samples. The prevalence of MetS was 30%, corresponding to the prevalence in the 50- to 80-year-old males from the background population. In individuals with MetS, hyperglycemia was more frequent in the HSCT survivors compared with age-matched controls with MetS (76% versus 20%; P < .001), whereas hypertension was more dominant in the control group with MetS (69% versus 93%; P = .01). In addition, normal or low body mass index was more commonly observed among HSCT survivors with MetS compared with age-matched controls with MetS (41% versus 11%; P = .002). MetS was more often associated with total body irradiation (TBI) compared with chemotherapy regimens (odds ratio [OR], 4.3; 95% confidence interval [CI], 1.2 to 24.4; P = .02), lower testosterone levels (OR, 5.4; 95% CI, 1.3 to 23.6; P = .02), higher IL-6 levels (OR, 1.8; 95% CI, 1.2 to 2.8; P = .004), and higher hsCRP levels (OR, 1.8; 95% CI, 1.3 to 2.6; P < .001) (estimates per 2-fold increase). In addition, an increased android/gynoid (AG) fat ratio was strongly associated with MetS (OR, 2.1; 95% CI, 1.5 to 2.9; P < .001), even though only 7% of patients met the criteria for increased abdominal circumference. Our results indicate an increased risk of MetS in early adulthood after pediatric HSCT. The clinical manifestations differed from those seen in age-matched controls with MetS, indicating different pathophysiology driven by hyperglycemia, altered fat distribution (despite no clinical abdominal obesity), and low-grade inflammation. Risk factors included TBI-based conditioning and low testosterone levels. These results underline the importance of continuous clinical assessment of the cardiometabolic risk profile and stress the presence of important dissimilarities in the pathophysiology of MetS in HSCT survivors compared with the background population. (c) 2021 The American Society for Transplantation and Cellular Therapy. Published by Elsevier Inc. All rights reserved.
C1 [Muhic, Ena; Mathiesen, Sidsel; Nielsen, Malene Mejdahl; Sorensen, Kaspar; Ifversen, Marianne; Muller, Klaus] Univ Copenhagen, Rigshosp, Dept Pediat & Adolescent Med, Blegdamsvej 9, DK-2100 Copenhagen, Denmark.
   [Muhic, Ena; Mathiesen, Sidsel; Nielsen, Malene Mejdahl; Muller, Klaus] Univ Copenhagen, Rigshosp, Inst Inflammat Res, Copenhagen, Denmark.
   [Suominen, Anu; Jahnukainen, Kirsi] Univ Helsinki, Childrens Hosp, Div Hematol Oncol & Stem Cell Transplantat, Helsinki, Finland.
   [Nolsoe, Runa Louise] Helsinki Univ Hosp, Helsinki, Finland.
   [Pedersen, Kasper Monsted; Nordestgaard, Borge Gronne] Univ Copenhagen, Nordsjaellands Hosp, Dept Nephrol & Endocrinol, Hillerod, Denmark.
   [Pedersen, Kasper Monsted; Nordestgaard, Borge Gronne] Univ Copenhagen, Fac Hlth & Med Sci, Copenhagen, Denmark.
   [Lahteenmaki, Paivi] Turku Univ Hosp, Dept Pediat & Adolescent Med, Turku, Finland.
   [Lahteenmaki, Paivi] Turku Univ, Turku, Finland.
   [Juul, Anders] Univ Copenhagen, Rigshosp, Dept Growth & Reprod, Copenhagen, Denmark.
   [Jahnukainen, Kirsi] Karolinska Inst, Dept Womens & Childrens Hlth, Nordfertil Res Lab Stockholm, Solna, Sweden.
   [Jahnukainen, Kirsi] Univ Hosp, Solna, Sweden.
   [Muller, Klaus] Univ Copenhagen, Inst Clin Med, Copenhagen, Denmark.
C3 University of Copenhagen; Copenhagen University Hospital;
   Rigshospitalet; University of Copenhagen; Copenhagen University
   Hospital; Rigshospitalet; University of Helsinki; University of
   Helsinki; Helsinki University Central Hospital; University of
   Copenhagen; University of Copenhagen; University of Turku; University of
   Turku; University of Copenhagen; Copenhagen University Hospital;
   Rigshospitalet; Karolinska Institutet; University of Copenhagen
RP Müller, K (corresponding author), Univ Copenhagen, Rigshosp, Dept Pediat & Adolescent Med, Blegdamsvej 9, DK-2100 Copenhagen, Denmark.; Müller, K (corresponding author), Univ Copenhagen, Rigshosp, Inst Inflammat Res, Copenhagen, Denmark.
EM klaus.mueller@regionh.dk
RI Muller, Klaus/JVN-5112-2024; Juul, Anders/F-5864-2013; Nordestgaard,
   Borge/ABF-1310-2020; Ifversen, Marianne/AAN-4016-2021
OI Mejdahl, Malene Asp Bock/0000-0002-2223-4938; Juul,
   Anders/0000-0002-0534-4350; Nordestgaard, Borge/0000-0002-1954-7220
FU Danish Childhood Cancer Foundation [2015-15, 2016-0261]; Rigshospitalet
   Research Foundation; Danish Cancer Society [R165-A10527]; Danish Cancer
   Research Foundation; Dagmar Marshall Foundation; Hartmann Brothers
   Foundation [A30640]; Finnish Cancer Society; Finnish Foundation of
   Pediatric Research; Helsinki University Research Foundation; Swedish
   Childhood Cancer Foundation [PR2017-0037, TJ2015-0046]; Swedish Research
   Council [2016-01296]; Danish Karen Elise Jensen Foundation; Vinnova
   [2016-01296] Funding Source: Vinnova; Swedish Research Council
   [2016-01296] Funding Source: Swedish Research Council
FX This study was supported by the Danish Childhood Cancer Foundation
   (2015-15 and 2016-0261), the Rigshospitalet Research Foundation, the
   Danish Cancer Society (R165-A10527), the Danish Cancer Research
   Foundation, the Dagmar Marshall Foundation, the Hartmann Brothers
   Foundation (A30640), the Finnish Cancer Society, the Finnish Foundation
   of Pediatric Research, the Helsinki University Research Foundation, the
   Swedish Childhood Cancer Foundation (PR2017-0037 and TJ2015-0046), and
   the Swedish Research Council (2016-01296). K.M.P. and B.G.N. were
   supported by the Danish Karen Elise Jensen Foundation.
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NR 32
TC 12
Z9 12
U1 0
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 2666-6375
EI 2666-6367
J9 TRANSPL CELL THER
JI Transpl. Cell. Ther.
PD SEP
PY 2021
VL 27
IS 9
DI 10.1016/j.jtct.2021.05.025
EA AUG 2021
PG 8
WC Hematology; Immunology; Transplantation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Hematology; Immunology; Transplantation
GA UI0WS
UT WOS:000690339400020
PM 34091072
OA hybrid
DA 2025-06-11
ER

PT J
AU Cayli, S
   Alimogullari, E
   Piskin, I
   Bilginoglu, A
   Nakkas, H
AF Cayli, Sevil
   Alimogullari, Ebru
   Piskin, Ilkay
   Bilginoglu, Ayca
   Nakkas, Hilal
TI Effect of pioglitazone on the expression of ubiquitin proteasome system
   and autophagic proteins in rat pancreas with metabolic syndrome
SO JOURNAL OF MOLECULAR HISTOLOGY
LA English
DT Article
DE p97; VCP; SVIP; Autophagy; Metabolic syndrome; Pancreas; Rat
ID INDUCED OXIDATIVE STRESS; BETA-CELL APOPTOSIS; PPAR-GAMMA;
   ENDOPLASMIC-RETICULUM; INSULIN SENSITIVITY; DB/DB MICE; GLUCOSE;
   GLUCOKINASE; PREVENTS; THERAPY
AB The metabolic syndrome (MetS) and pathologies associated with metabolic dysregulations a worldwide growing problem. Our previous study demonstrated that pioglitazone (PGZ) has beneficial effects on metabolic syndrome associated disturbances in the heart. However, mechanism mediating the molecular alterations of Ubiquitin proteasome system (UPS) and autophagy has not been investigated in rat pancreas with metabolic syndrome. For this reason, we first aimed to detect whether MetS effects on the expression of UPS (p97/VCP, SVIP, Ubiquitin) and autophagic (p62, LC3) proteins in rat pancreas. The second aim of the study was to find impact of pioglitazone on the expression of UPS and autophagic proteins in MetS rat pancreas. To answer these questions, metabolic syndrome induced rats were used as a model and treated with pioglitazone for 2 weeks. Pancreatic tissue injuries, fibrosis and lipid accumulation were evaluated histopathologically in control, MetS and MetS-PGZ groups. Apoptosis and cell proliferation of pancreatic islet cells were assessed in all groups. UPS and autophagic protein expressions of pancreas in all groups were detected by using immunohistochemistry, double-immunfluorescence and Western blotting. Compared with the controls, the rat fed with high sucrose exhibited signs of metabolic syndrome, such as higher body weight, insulin resistance, higher triglyceride level and hyperglycaemia. MetS rats showed pancreatic tissue degeneration, fibrosis and lipid accumulation when their pancreas were examined with Hematoxilen-eozin and Mallory trichrome staining. Metabolic, histopathologic parameters and cell proliferation showed greater improvement in MetS-PGZ rats and pioglitazone decreased apoptosis of islet cells. Moreover, SVIP, ubiquitin, LC3 and p62 expressions were significantly increased while only p97/VCP expression was significantly decreased in MetS-rat pancreas compared to control. PGZ treatment significantly decreased the MetS-induced increases in autophagy markers. Additionally, UPS and autophagy markers were found to colocalizated with insulin and glucagon. Colocalization ratio of UPS markers with insulin showed significant decrease in MetS rats and PGZ increased this ratio, whereas LC3-insulin colocalization displayed significant increase in MetS rats and PGZ reversed this effect. In conclusion, PGZ improved the pancreatic tissue degeneration by increasing the level of p97/VCP and decreasing autophagic proteins, SVIP and ubiquitin expressions in MetS-rats. Moreover, PGZ has an effect on the colocalization ratio of UPS and autophagy markers with insulin.
C1 [Cayli, Sevil; Alimogullari, Ebru; Piskin, Ilkay; Nakkas, Hilal] Ankara Yildirim Beyazit Univ, Fac Med, Dept Histol & Embryol, TR-06800 Ankara, Turkey.
   [Bilginoglu, Ayca] Ankara Yildirim Beyazit Univ, Fac Med, Dept Biophys, Ankara, Turkey.
C3 Ankara Yildirim Beyazit University; Ankara Yildirim Beyazit University
RP Cayli, S (corresponding author), Ankara Yildirim Beyazit Univ, Fac Med, Dept Histol & Embryol, TR-06800 Ankara, Turkey.
EM sevilcayli@yahoo.com
RI Cayli, Sevil/V-2342-2019; Piskin, Ilkay/LBH-6303-2024; Bilginoglu Topcu,
   Ayca/J-8076-2018; NAKKAŞ, HİLAL/AGF-6945-2022
OI BILGINOGLU, AYCA/0000-0002-1657-2607; Corumluoglu Piskin,
   Ilkay/0000-0002-5125-302X; NAKKAS, HILAL/0000-0003-0901-8875; Cayli,
   Sevil/0000-0003-2465-5389
FU Turkish Research Council (TUBITAK) [115S827]
FX This study was partially supported by Turkish Research Council (TUBITAK)
   with project number: 115S827.
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NR 44
TC 3
Z9 3
U1 1
U2 6
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1567-2379
EI 1567-2387
J9 J MOL HISTOL
JI J. Mol. Histol.
PD OCT
PY 2021
VL 52
IS 5
BP 929
EP 942
DI 10.1007/s10735-021-10013-1
EA AUG 2021
PG 14
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA WA6XI
UT WOS:000686498100001
PM 34410563
DA 2025-06-11
ER

PT J
AU Godin, O
   Bennabi, D
   Yrondi, A
   Richieri, R
   D'Amato, T
   Bellivier, F
   Bougerol, T
   Horn, M
   Camus, V
   Courtet, P
   Doumy, O
   Genty, JB
   El-Hage, W
   Haesebaert, F
   Holtzmann, J
   Lancon, C
   Leboyer, M
   Llorca, PM
   Maruani, J
   Molière, F
   Samalin, L
   Schmitt, L
   Stephan, F
   Vaiva, G
   Walter, M
   Aouizerate, B
   Haffen, E
AF Godin, Ophelia
   Bennabi, Djamila
   Yrondi, Antoine
   Richieri, Raphaelle
   D'Amato, Thierry
   Bellivier, Franck
   Bougerol, Thierry
   Horn, Mathilde
   Camus, Vincent
   Courtet, Philippe
   Doumy, Olivier
   Genty, Jean Baptiste
   El-Hage, Wissam
   Haesebaert, Frederic
   Holtzmann, Jerome
   Lancon, Christophe
   Leboyer, Marion
   Llorca, Pierre Michel
   Maruani, Julia
   Moliere, Fanny
   Samalin, Ludovic
   Schmitt, Laurent
   Stephan, Florian
   Vaiva, Guillaume
   Walter, Michel
   Aouizerate, Bruno
   Haffen, Emmanuel
CA FondaMental Adv Ctr Expertise Resi
TI Prevalence of Metabolic Syndrome and Associated Factors in a Cohort of
   Individuals With Treatment-Resistant Depression: Results From the
   FACE-DR Study
SO JOURNAL OF CLINICAL PSYCHIATRY
LA English
DT Article
ID STAR-ASTERISK-D; CARDIOVASCULAR-DISEASE; MYOCARDIAL-INFARCTION; BIPOLAR
   DISORDER; RISK-FACTORS; SCHIZOPHRENIA; METAANALYSIS; COMPONENTS;
   OBESITY; DYSREGULATION
AB Background: The aim of this study was to estimate the prevalence of metabolic syndrome (MetS) and its components in a cohort of French patients with treatment-resistant depression (TRD) and to determine correlations with sociodemographic, clinical, and treatment-related factors.
   Methods: From 2012 to 2018, 205 patients who met DSM-IV criteria for major depressive episode with moderate-to-severe symptoms (Montgomery-Asberg Depression Rating Scale score >= 20), and at least Stage II resistance according to Thase and Rush criteria were enrolled in the FondaMental Advanced Centers of Expertise in Resistant Depression (FACE-DR) cohort. Data on sociodemographic and clinical characteristics, lifestyle information, and treatment and comorbidities were collected, and a blood sample was drawn. MetS was defined according to the criteria of the International Diabetes Federation.
   Results: Overall, 38% of individuals with TRD met criteria for MetS. The frequency of MetS was significantly higher in men than in women only for patients aged 40 years or older (463% vs 35.2%, P=.0427). Moreover, whereas the management for diabetes was good, less than one-third of the patients with high blood pressure or dyslipidemia were treated for these conditions. Multivariate analysis showed that individuals with abnormal plasma c-reactive protein levels had a 3-fold increased risk (95% CI, 1.5-5.2) of having MetS, independent of other potential confounders.
   Conclusion: The prevalence of MetS is higher in patients with TRD than in those with other psychiatric disorders and characterized by a considerable undertreatment of some components of MetS in this population. Diagnosis and treatment of the components of MetS should be systematically performed to prevent the occurrence of cardiovascular diseases in patients with TRD. These findings highlight the need for integrated care, with more interaction and coordination between psychiatrists and primary care providers.
C1 [Godin, Ophelia; Bennabi, Djamila; Yrondi, Antoine; Richieri, Raphaelle; D'Amato, Thierry; Bellivier, Franck; Bougerol, Thierry; Horn, Mathilde; Camus, Vincent; Courtet, Philippe; Doumy, Olivier; Genty, Jean Baptiste; El-Hage, Wissam; Haesebaert, Frederic; Holtzmann, Jerome; Lancon, Christophe; Leboyer, Marion; Llorca, Pierre Michel; Maruani, Julia; Moliere, Fanny; Samalin, Ludovic; Schmitt, Laurent; Stephan, Florian; Vaiva, Guillaume; Walter, Michel; Aouizerate, Bruno; Haffen, Emmanuel] FondaMental Fondat, Creteil, France.
   [Godin, Ophelia] Sorbonne Univ, IPLESP, INSERM, Paris, France.
   [Bennabi, Djamila; Haffen, Emmanuel] Bourgogne Franche Comte Univ, Treatment Resistant Depress Fondamental Expert Ct, Clin Psychiat Dept, EA Neurosci 481, Besancon, France.
   [Yrondi, Antoine; Schmitt, Laurent] CHRU Toulouse, Fondamental Expert Ctr Treatment Resistant Depres, Psychiat & Med Psychol Dept, Purpan Hosp, Toulouse, France.
   [Richieri, Raphaelle; Lancon, Christophe] CHU La Conception, Psychiat Dept, Fondamental Expert Ctr Treatment Resistant Depres, Marseille, France.
   [D'Amato, Thierry; Haesebaert, Frederic] Le Vinatier Hosp, Univ Hosp Dept Adult Psychiat, Fondamental Expert Ctr Treatment Resistant Depres, Bron, France.
   [Bellivier, Franck; Maruani, Julia] Univ Paris Diderot, GH St Louis Lariboisiere Fernand Widal, AP HP, INSERM,UMRS 1144, Paris, France.
   [Bougerol, Thierry; El-Hage, Wissam; Holtzmann, Jerome] Univ Joseph Fourier Grenoble I, BP 53, Grenoble, France.
   [Bougerol, Thierry; Holtzmann, Jerome; Moliere, Fanny] CHU Grenoble, Grenoble, France.
   [Bougerol, Thierry; Holtzmann, Jerome] GIN, Inserm U836, Chemin Fortune Ferrini, La Tronche, France.
   [Horn, Mathilde; Vaiva, Guillaume] Lille Univ, Fontan Hosp, Fondamental Expert Ctr Treatment Resistant Depres, Dept Adult Psychiat,CHU Lille,CNRS,UMR 9193, Lille, France.
   [Camus, Vincent; Doumy, Olivier] Tours Univ, Univ Psychiat Clin, Fondamental Expert Ctr Treatment Resistant Depres, CHRU Tours,Inserm U1253 Imaging & Brain iBrain, Tours, France.
   [Courtet, Philippe] Montpellier Univ, Dept Emergency Psychiat & Acute Care, INSERM U1061, CHU Montpellier, Montpellier, France.
   [Aouizerate, Bruno] Bordeaux Univ, Univ Dept Psychiat, Fondamental Expert Ctr Treatment Resistant Depres, CH Charles Perrens,NutriNeuro UMR INRA 1286, Bordeaux, France.
   [Genty, Jean Baptiste; Leboyer, Marion] Paris Est Univ, UPEC, UMR S955, Creteil, France.
   [Genty, Jean Baptiste; Leboyer, Marion] INSERM, U955 Team 15, Creteil, France.
   [Genty, Jean Baptiste; Leboyer, Marion] H Mondor A Chenevier Hosp, AP HP, Psychiat Dept, Creteil, France.
   [Llorca, Pierre Michel; Samalin, Ludovic; Stephan, Florian] Clermont Ferrand Univ, Fondamental Expert Ctr Treatment Resistant Depres, EA7280, CHU Clermont Ferrand, Clermont Ferrand, France.
   [Walter, Michel] CHRU Brest, Bohars Hosp, Dept Gen Psychiat & Psychosocial Rehabil 29G01 &, Fondamental Expert Ctr Treatment Resistant Depres, Bohars, France.
C3 Institut National de la Sante et de la Recherche Medicale (Inserm);
   Sorbonne Universite; Universite de Franche-Comte; CHU de Toulouse;
   Aix-Marseille Universite; Assistance Publique-Hopitaux de Marseille;
   Universite Paris Cite; Assistance Publique Hopitaux Paris (APHP);
   Hopital Universitaire Lariboisiere-Fernand-Widal - APHP; Institut
   National de la Sante et de la Recherche Medicale (Inserm); Hopital
   Universitaire Saint-Louis - APHP; Communaute Universite Grenoble Alpes;
   Universite Grenoble Alpes (UGA); Communaute Universite Grenoble Alpes;
   Universite Grenoble Alpes (UGA); CHU Grenoble Alpes; CEA; Centre
   National de la Recherche Scientifique (CNRS); Institut National de la
   Sante et de la Recherche Medicale (Inserm); Universite de Lille; CHU
   Lille; Centre National de la Recherche Scientifique (CNRS); CNRS -
   Institute for Humanities & Social Sciences (INSHS); CHU Tours; Institut
   National de la Sante et de la Recherche Medicale (Inserm); Universite de
   Montpellier; CHU de Montpellier; Universite de Bordeaux; INRAE;
   Universite Paris-Est-Creteil-Val-de-Marne (UPEC); Institut National de
   la Sante et de la Recherche Medicale (Inserm); Universite
   Paris-Est-Creteil-Val-de-Marne (UPEC); Assistance Publique Hopitaux
   Paris (APHP); Universite Paris-Est-Creteil-Val-de-Marne (UPEC); Hopital
   Universitaire Henri-Mondor - APHP; Universite Clermont Auvergne (UCA);
   CHU Clermont Ferrand; CHU Brest
RP Godin, O (corresponding author), Hop La Pitie Salpetriere, Inst Pierre Louis Epidemiol & Sante Publ, UMR S 1136, F-75651 Paris 13, France.
EM ophelia.godin@upmc.fr
RI Fond, Guillaume/D-7646-2011; richieri, raphaelle/E-4707-2015; haffen,
   emmanuel/R-2765-2017; EL-HAGE, WISSAM/S-5014-2019; Leboyer,
   Marion/AAW-3648-2021; Samalin, Ludovic/AAP-6362-2020; djamila,
   bennabi/AAI-7456-2020; Camus, Vincent/ABC-4021-2020; Haesebaert,
   Frederic/D-9264-2018; VAIVA, Guillaume/J-8983-2015
OI RICHIERI, Raphaelle/0000-0002-3901-7016; Haesebaert,
   Frederic/0000-0002-6813-9012; Aouizerate, Bruno/0000-0002-7092-7747;
   Samalin, Ludovic/0000-0003-0740-4019; Bennabi,
   Djamila/0000-0001-5080-2501; VAIVA, Guillaume/0000-0003-2462-008X;
   EL-HAGE, WISSAM/0000-0003-3877-0855; Yrondi,
   Antoine/0000-0002-2650-6080; Horn, Mathilde/0000-0001-8968-9454; Cazals,
   Aurelie/0000-0002-4907-8568
FU Fondation FondaMental; Institut National de la Sante et de la Recherche
   Medicale (INSERM); AP-HP (Assistance Publique des Hopitaux de Paris);
   Astra Zeneca; Investissements d'Avenir program [ANR-11-IDEX-0004-02]
FX This research was supported by the Fondation FondaMental, Institut
   National de la Sante et de la Recherche Medicale (INSERM), AP-HP
   (Assistance Publique des Hopitaux de Paris), Astra Zeneca, and the
   Investissements d'Avenir program managed by the ANR under reference
   ANR-11-IDEX-0004-02.
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NR 48
TC 20
Z9 21
U1 0
U2 5
PU PHYSICIANS POSTGRADUATE PRESS
PI MEMPHIS
PA P O BOX 752870, MEMPHIS, TN 38175-2870 USA
SN 0160-6689
EI 1555-2101
J9 J CLIN PSYCHIAT
JI J. Clin. Psychiatry
PD NOV-DEC
PY 2019
VL 80
IS 6
AR 19m12755
DI 10.4088/JCP.19m12755
PG 9
WC Psychology, Clinical; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA KR7NW
UT WOS:000517803900009
PM 31617968
DA 2025-06-11
ER

PT J
AU Pinto, BAS
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   Torres Flister, Karla Frida
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   Moreira, Vanessa Ribeiro
   Kajihara, Daniela
   Mendes, Nelmar Oliveira
   Pereira, Silma Regina
   Martins Laurindo, Francisco Rafael
   Andrade Paes, Antonio Marcus
TI Hippocampal Endoplasmic Reticulum Stress Hastens Motor and Cognitive
   Decline in Adult Male Rats Sustainedly Exposed to High-Sucrose Diet
SO ANTIOXIDANTS
LA English
DT Article
DE high-sucrose diet; metabolic syndrome; hippocampus; ER stress; cognitive
   and motor impairments
ID UNFOLDED PROTEIN RESPONSE; INDUCED INSULIN-RESISTANCE; FRUCTOSE CORN
   SYRUP; OXIDATIVE STRESS; INDUCED OBESITY; ER STRESS; SPATIAL MEMORY;
   BRAIN; CONSUMPTION; GLUCOSE
AB Metabolic dysfunctions, such as hyperglycemia and insulin resistance, have been associated to cognitive impairment and dementia regardless of advanced age, although the underlying mechanisms are still elusive. Thus, this study investigates the deleterious effects of metabolic syndrome (MetS) induced by long-term exposure to a high-sucrose diet on motor and cognitive functions of male adult rats and its relationship with hippocampal endoplasmic reticulum (ER) stress. Weaned Wistar male rats were fed a high-sucrose diet until adulthood (HSD; 6 months old) and compared to both age-matched (CTR; 6 months old) and middle-aged chow-fed rats (OLD; 20 months old). MetS development, serum redox profile, behavioral, motor, and cognitive functions, and hippocampal gene/protein expressions for ER stress pro-adaptive and pro-apoptotic pathways, as well as senescence markers were assessed. Prolonged exposure to HSD induced MetS hallmarked by body weight gain associated to central obesity, hypertriglyceridemia, insulin resistance, and oxidative stress. Furthermore, HSD rats showed motor and cognitive decline similar to that in OLD animals. Noteworthy, HSD rats presented marked hippocampal ER stress characterized by failure of pro-adaptive signaling and increased expression of Chop, p21, and Parp-1 cleavage, markers of cell death and aging. This panorama resembles that found in OLD rats. In toto, our data showed that early and sustained exposure to a high-sucrose diet induced MetS, which subsequently led to hippocampus homeostasis disruption and premature impairment of motor and cognitive functions in adult rats.
C1 [Serra Pinto, Bruno Araujo; Melo, Thamys Marinho; Torres Flister, Karla Frida; Franca, Lucas Martins; Mendes, Nelmar Oliveira; Andrade Paes, Antonio Marcus] Univ Fed Maranhao, Dept Physiol Sci, Lab Expt Physiol, Av Portugueses 1966, BR-65080805 Sao Luis, Maranhao, Brazil.
   [Moreira, Vanessa Ribeiro; Pereira, Silma Regina] Univ Fed Maranhao, Dept Biol, Lab Genet & Mol Biol, Av Portugueses 1966, BR-65080805 Sao Luis, Maranhao, Brazil.
   [Kajihara, Daniela; Martins Laurindo, Francisco Rafael] Univ Sao Paulo, Sch Med, Heart Inst, Lab Vasc Biol, Av Dr Eneas Carvalho Aguilar 44, BR-05403900 Sao Paulo, SP, Brazil.
C3 Universidade Federal do Maranhao; Universidade Federal do Maranhao;
   Universidade de Sao Paulo
RP Paes, AMA (corresponding author), Univ Fed Maranhao, Dept Physiol Sci, Lab Expt Physiol, Av Portugueses 1966, BR-65080805 Sao Luis, Maranhao, Brazil.
EM bruno.pinto@ufma.br; thamys.marinho@discente.ufma.br;
   karla.flister@ufma.br; lucas.mf@ufma.br; more_nessa@yahoo.com.br;
   d.kajihara@hc.fm.usp.br; nelmar.mendes@discente.ufma.br;
   silma.pereira@ufma.br; francisco.laurindo@incor.usp.br;
   marcuspaes@ufma.br
RI França, Lucas/IAM-5986-2023; Laurindo, Francisco/J-6575-2015; moreira,
   vanessa/GQO-7744-2022; Kajihara, Daniela/AAR-1172-2020; Paes, Antonio
   Marcus de Andrade/C-7174-2013
OI Paes, Antonio Marcus de Andrade/0000-0002-3803-9803; Kajihara,
   Daniela/0000-0001-9239-4198; Martins Franca, Lucas/0000-0002-4412-1539;
   ARAUJO SERRA PINTO, BRUNO/0000-0003-3595-0578; Laurindo,
   Francisco/0000-0001-6837-4509
FU Fundacao deAmparo a Pesquisa e aoDesenvolvimento Cientifico e
   Tecnologico doMaranhao-FAPEMA [FAPEMA PAEDT-00380/14, PAEDT-02085/15,
   ESTAGIO-05258/15, UNIVERSAL-00523/14, UNIVERSAL-00792/14]; Coordenacao
   de Aperfeicoamento de Pessoal de Nivel Superior-CAPES [001]; Conselho
   Nacional de Desenvolvimento Cientifico e Tecnologico-CNPq
   [308163/2019-2]; FAPEMA [POS-GRAD-02598/21]
FX This researchwas funded by Fundacao deAmparo a Pesquisa e
   aoDesenvolvimento Cientifico e Tecnologico doMaranhao-FAPEMA, grant
   numbers FAPEMA PAEDT-00380/14, PAEDT-02085/15, ESTAGIO-05258/15,
   UNIVERSAL-00523/14, UNIVERSAL-00792/14; Coordenacao de Aperfeicoamento
   de Pessoal de Nivel Superior-CAPES, Finance Code 001 and fellowship to
   V.R.M.; and Conselho Nacional de Desenvolvimento Cientifico e
   Tecnologico-CNPq, fellowship to T.M.M. and A.M.A.P. (308163/2019-2). The
   APC was funded by FAPEMA, grant number POS-GRAD-02598/21.
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NR 84
TC 6
Z9 6
U1 0
U2 2
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD JUL
PY 2022
VL 11
IS 7
AR 1395
DI 10.3390/antiox11071395
PG 16
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA 3J8SD
UT WOS:000833659900001
PM 35883886
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Naderpoor, N
   Shorakae, S
   Joham, A
   Boyle, J
   De Courten, B
   Teede, HJ
AF Naderpoor, N.
   Shorakae, S.
   Joham, A.
   Boyle, J.
   De Courten, B.
   Teede, H. J.
TI Obesity and polycystic ovary syndrome
SO MINERVA ENDOCRINOLOGICA
LA English
DT Article
DE Obesity; Insulin resistance; Hyperandrogenism; Polycystic ovary syndrome
ID IMPAIRED GLUCOSE-TOLERANCE; BODY-MASS INDEX; TYPE-2 DIABETES-MELLITUS;
   NERVE GROWTH-FACTOR; INSULIN-RESISTANCE; WEIGHT-LOSS; METABOLIC
   SYNDROME; FAT DISTRIBUTION; LIFE-STYLE; PHYSICAL-ACTIVITY
AB Obesity is now a major international health concern. It is increasingly common in young women with reproductive, metabolic and psychological health impacts. Reproductive health impacts are often poorly appreciated and include polycystic ovary syndrome (PCOS), infertility and pregnancy complications. PCOS is the most common endocrine condition in women and is underpinned by hormonal disturbances including insulin resistance and hyperandrogenism. Obesity exacerbates hormonal and clinical features of PCOS and women with PCOS appear at higher risk of obesity, with multiple underlying mechanisms linking the conditions. Lifestyle intervention is first line in management of PCOS to both prevent weight gain and induce weight loss; however improved engagement and sustainability remain challenges with the need for more research. Medications like metformin, orlistat, GLP1 agonists and bariatric surgery have been used with the need for large scale randomised clinical trials to define their roles.
C1 [Naderpoor, N.; Shorakae, S.; Joham, A.; Boyle, J.; De Courten, B.; Teede, H. J.] Monash Univ, Sch Publ Hlth & Prevent Med, Monash Ctr Hlth Res & Implementat, MHRP, Clayton, Vic, Australia.
   [Teede, H. J.] Univ Adelaide, Robinson Res Inst, Discipline Obstet & Gynaecol, Adelaide, SA, Australia.
   [Naderpoor, N.; Shorakae, S.; Joham, A.; De Courten, B.; Teede, H. J.] Monash Hlth, Diabet & Vasc Med Unit, Clayton, Vic, Australia.
C3 Monash University; University of Adelaide; Robinson Research Institute;
   Monash Health
RP Teede, HJ (corresponding author), Monash Med Ctr, Locked Bag 29, Clayton, Vic 3168, Australia.
EM helena.teede@monash.edu
RI Joham, Anju/AAD-6020-2019; de Courten, Barbora/B-3308-2012; Boyle,
   Jacqueline/AAD-3246-2019; Naderpoor, Negar/IUM-7706-2023
OI Boyle, Jacqueline/0000-0002-3616-1637; Teede,
   Helena/0000-0001-7609-577X; Naderpoor, Negar/0000-0002-1738-3189
FU NHMRC
FX Prof Teede is an NHMRC Practitioner Fellow and Dr Joham and Dr Shorakae
   are NHMRC Scholarship holders.
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NR 118
TC 69
Z9 87
U1 0
U2 19
PU EDIZIONI MINERVA MEDICA
PI TURIN
PA CORSO BRAMANTE 83-85 INT JOURNALS DEPT., 10126 TURIN, ITALY
SN 0391-1977
EI 1827-1634
J9 MINERVA ENDOCRINOL
JI Minerva Endocrinol.
PD MAR
PY 2015
VL 40
IS 1
BP 37
EP 51
PG 15
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA CE7PQ
UT WOS:000352034200005
PM 25411807
DA 2025-06-11
ER

PT J
AU Irandoust, K
   Taheri, M
   Chtourou, H
   Nikolaidis, PT
   Rosemann, T
   Knechtle, B
AF Irandoust, Khadijah
   Taheri, Morteza
   Chtourou, Hamdi
   Nikolaidis, Pantelis Theo
   Rosemann, Thomas
   Knechtle, Beat
TI Effect of Time-of-Day-Exercise in Group Settings on Level of Mood and
   Depression of Former Elite Male Athletes
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Article
DE time-of-day; mood; depression; elite athlete
ID SYMPTOMS; OBESITY; SLEEP
AB Since the prevalence of depression is high among athletes at the end of their athletic career, the purpose of this study was to investigate the effect of time-of-day-exercise in group settings on the level of the mood and depression of former elite male athletes.Out of 187 volunteers referring to the sports counseling clinic, 71 retired male athletes who had a national championship record were randomly divided into two morning and evening exercise groups. The inclusion criteria were severe depression (high score in the Beck Depression Inventory-II), the age range of 50 to 60 years, the absence of metabolic syndrome, and the body mass index (BMI) between 28 and 35. All body composition variables were measured using body composition analysis (In Body 320; Korea). The second stage was the collection of data after three months (completion of the training protocol). After data collection, independent and dependent t-tests were used to analyze the data. The results indicated that both groups had a significant improvement in depression compared to the pre-test (p <= 0.05), while there was no significant difference between the two groups (p >= 0.05). The overall conclusion is that exercise at different times of the morning or evening can improve the psychological state and reduce depression.
C1 [Irandoust, Khadijah; Taheri, Morteza] Imam Khomeini Int Univ, Dept Sport Sci, Qazvin 3414896818, Iran.
   [Chtourou, Hamdi] Observ Natl Sport, UR18JS01, Act Phys Sport & Sante, Tunis 1003, Tunisia.
   [Chtourou, Hamdi] Univ Sfax, Inst Superieur Sport & Educ Phys Sfax, Sfax 3000, Tunisia.
   [Nikolaidis, Pantelis Theo] Exercise Physiol Lab, Nikaia 18450, Greece.
   [Rosemann, Thomas] Univ Zurich, Inst Primary Care, CH-8091 Zurich, Switzerland.
   [Knechtle, Beat] Medbase St Gallen Vadianplatz, CH-9001 St Gallen, Switzerland.
C3 Imam Khomeini International University; Universite de Sfax; University
   of Zurich
RP Knechtle, B (corresponding author), Medbase St Gallen Vadianplatz, CH-9001 St Gallen, Switzerland.
EM irandoust@soc.ikiu.ac.ir; m.taheri@soc.ikiu.ac.ir; h_chtourou@yahoo.fr;
   pademil@hotmail.com; thomas.rosemann@usz.ch; beat.knechtle@hispeed.ch
RI Knechtle, Beat/ABC-5529-2020; irandoust, khadijeh/ABH-3519-2021;
   Morteza, Taheri/N-5170-2016; Chtourou, Hamdi/AEZ-6215-2022; Nikolaidis,
   Pantelis/K-8664-2017
OI Irandoust, Khadijeh/0000-0001-5839-9753; Knechtle,
   Beat/0000-0002-2412-9103; Morteza, Taheri/0000-0001-8031-3792; Rosemann,
   Thomas/0000-0002-6436-6306; Chtourou, Hamdi/0000-0002-5482-9151;
   Nikolaidis, Pantelis/0000-0001-8030-7122
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NR 36
TC 20
Z9 22
U1 1
U2 12
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD OCT
PY 2019
VL 16
IS 19
AR 3541
DI 10.3390/ijerph16193541
PG 8
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA JK3MF
UT WOS:000494748600037
PM 31546685
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Rendina, D
   Ippolito, R
   De Filippo, G
   Muscariello, R
   De Palma, D
   De Bonis, S
   di Cola, MS
   Benvenuto, D
   Galderisi, M
   Strazzullo, P
   Galletti, F
AF Rendina, Domenico
   Ippolito, Renato
   De Filippo, Gianpaolo
   Muscariello, Riccardo
   De Palma, Daniela
   De Bonis, Silvana
   di Cola, Michele Schiano
   Benvenuto, Domenico
   Galderisi, Maurizio
   Strazzullo, Pasquale
   Galletti, Ferruccio
TI Risk factors for silent myocardial ischemia in patients with
   well-controlled essential hypertension
SO INTERNAL AND EMERGENCY MEDICINE
LA English
DT Article
DE Asymptomatic coronary artery disease; Blood pressure control; 24-h
   ambulatory blood pressure monitoring; 24-h ambulatory electrocardiogram
ID ST-SEGMENT DEPRESSION; CORONARY-ARTERY-DISEASE; BLOOD-PRESSURE;
   METABOLIC SYNDROME; CLINICAL ELECTROCARDIOGRAPHY; CIRCADIAN VARIATION;
   INDEPENDENT PREDICTOR; INPATIENT POPULATION; CARDIAC ISCHEMIA; PULSE
   PRESSURE
AB Silent myocardial ischemia (SMI) is frequently observed in patients with essential hypertension (EH). The major risk factor for SMI is uncontrolled blood pressure (BP), but SMI is also observed in patients with well-controlled BP. To evaluate the prevalence of SMI and the factors associated with SMI in EH patients with well-controlled BP. The medical records of 859 EH patients who underwent simultaneous 24-h ambulatory blood pressure monitoring (ABPM) and 24-h ambulatory electrocardiogram recording (AECG) were retrospectively evaluated. Each SMI episode was characterized by: (a) ST segment depression >0.5 mm; (b) duration of ST segment depression > 60 s; and (c) reversibility of the ST segment depression. Overall 126 EH patients (14.7 %) had at least one episode of SMI. The SMI events were more frequent among patients with poorly controlled compared to those with well-controlled BP [86/479 (17.95 %) vs. 40/380 (10.52 %), p < 0.01]. Among EH patients with well-controlled BP, current and past smoking as well as the presence of an additional metabolic syndrome (MetS) constitutive element (obesity, impaired fasting glucose level or dyslipidemia) were significantly associated with the occurrence of SMI. In all EH patients with well-controlled BP and AECG evidence of SMI, there were one or more coronary artery stenotic lesions greater than 50 % found at coronary angiography. In EH patients who are current smokers, or have one or more additional components of a MetS there is markedly reduced benefit associated with good BP control with regard to the occurrence of myocardial ischemia: in this patient category, an AECG may help detect this condition.
C1 [Rendina, Domenico; Ippolito, Renato; De Filippo, Gianpaolo; Muscariello, Riccardo; De Palma, Daniela; di Cola, Michele Schiano; Strazzullo, Pasquale; Galletti, Ferruccio] Univ Naples Federico II, Dept Clin Med & Surg, Via Pansini 5, I-80131 Naples, Italy.
   [Rendina, Domenico; De Bonis, Silvana; Benvenuto, Domenico] Spinelli Hosp, Cosenza, Italy.
   [De Filippo, Gianpaolo] Hop Bicetre, AP HP, Unite Diabet Hypertens Nutr Adolescent, Le Kremlin Bicetre, France.
   [De Bonis, Silvana] Ferrari Hosp, Cardiol Unit, Cosenza, Italy.
   [Galderisi, Maurizio] Univ Naples Federico II, Dept Adv Clin Sci, Naples, Italy.
C3 University of Naples Federico II; Assistance Publique Hopitaux Paris
   (APHP); Hopital Universitaire Bicetre - APHP; Universite Paris Saclay;
   Hopital Universitaire Antoine-Beclere - APHP; University of Naples
   Federico II
RP Rendina, D (corresponding author), Univ Naples Federico II, Dept Clin Med & Surg, Via Pansini 5, I-80131 Naples, Italy.; Rendina, D (corresponding author), Spinelli Hosp, Cosenza, Italy.
EM domenico.rendina@unina.it
RI Muscariello, Riccardo/AAW-1394-2020; Galletti, Ferruccio/B-8923-2013;
   De+Filippo, Gianpaolo/AAE-5584-2019
OI Galletti, Ferruccio/0000-0001-7556-0254; Rendina,
   Domenico/0000-0002-0331-0392
FU Stroder/Societa Italiana dell'Osteoporosi del Metabolismo Minerale e
   delle Malattie dello Scheletro; Societa Italiana Medicina Interna
FX The authors are grateful to the owners and the medical director of the
   Spinelli Hospital who granted the free use of the facilities and
   services required to conduct the study. This study was supported by
   unrestricted grants from Stroder/Societa Italiana dell'Osteoporosi del
   Metabolismo Minerale e delle Malattie dello Scheletro (to DR) and
   Societa Italiana Medicina Interna (to RI).
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NR 53
TC 4
Z9 5
U1 0
U2 3
PU SPRINGER-VERLAG ITALIA SRL
PI MILAN
PA VIA DECEMBRIO, 28, MILAN, 20137, ITALY
SN 1828-0447
EI 1970-9366
J9 INTERN EMERG MED
JI Intern. Emerg. Med.
PD MAR
PY 2017
VL 12
IS 2
BP 171
EP 179
DI 10.1007/s11739-016-1527-2
PG 9
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA EM6VL
UT WOS:000395450400005
PM 27565986
DA 2025-06-11
ER

PT J
AU Zeman, M
   Jirak, R
   Jachymova, M
   Vecka, M
   Tvrzicka, E
   Zak, A
AF Zeman, Miroslav
   Jirak, Roman
   Jachymova, Marie
   Vecka, Marek
   Tvrzicka, Eva
   Zak, Ales
TI Leptin, adiponectin, leptin to adiponectin ratio and insulin resistance
   in depressive women
SO NEUROENDOCRINOLOGY LETTERS
LA English
DT Article
DE depression; leptin; adiponectin; insulin resistance; leptin to
   adiponectin ratio; metabolic syndrome
ID BINGE-EATING DISORDER; MAJOR DEPRESSION; CARDIOVASCULAR-DISEASE;
   GLUCOSE-HOMEOSTASIS; PLASMA LEPTIN; ASSOCIATION; OBESITY; TYPE-2;
   SENSITIVITY; SEROTONIN
AB BACKGROUND: Depressive disorder (DD) is associated with an increased risk of type 2 diabetes mellitus (DM2) and cardiovascular disease (CVD). It was suggested, that metabolic syndrome (MetS), cluster of metabolic and hormonal changes, such as insulin resistence (IR), abdominal obesity, dyslipidemia, arterial hypertension and elevated fasting glycaemia, could stand behind the connection. Recent findings have shown, that adipocytokines leptin and adiponectin might play a role in both depression and MetS.
   AIM: The aim of this pilot study was to observe the plasma concentrations of leptin, adiponectin, leptin-to-adiponectin ratio and indices of IR in women with depressive disorder.
   MATERIALS AND METHODS: The plasma leptin, adiponectin, parameters of lipid and glucose homeostasis and indices of IR were investigated in a group of 38 women with DD. The results were compared with those of 38 healthy women of the control group, matched for age.
   RESULTS: Depressive women differed significantly from the controls in higher concentrations of Plasma leptin (p<0.05), insulin (p<0.01), C-peptide (p<0.01), value of HOMA-IR (p<0.01), and the leptin-to-adiponectin ratio (p<0.05). he QUICKI index of insulin sensitivity was lower (p<0.01). HAM-D score of DID cases correlated negatively with adiponectin (r=-0.3505; p<0.05), independently of HOMA-IR. We have not found in DD group any differences between the drug free patients and those treated either with escitaloprame alone or in the combination with :mirtazapine.
   CONCLUSIONS: The results of the pilot study presented support the hypothesis that at least part of DD cases has increased leptin serum levels and certain features of MetS. It could be the factor connecting depression with an increased risk of either DM2 or CVD.
C1 [Zeman, Miroslav] Charles Univ Prague, Fac Med 1, Dept Internal Med 4, Prague 12808 2, Czech Republic.
   [Jirak, Roman] Charles Univ Prague, Fac Med 1, Dept Psychiat, Prague 12808 2, Czech Republic.
C3 Charles University Prague; Charles University Prague; General University
   Hospital Prague
RP Zeman, M (corresponding author), Charles Univ Prague, Fac Med 1, Dept Internal Med 4, U Nemocnice 2, Prague 12808 2, Czech Republic.
EM mirozem@seznam.cz
RI Jirak, Roman/O-1658-2017; Vecka, Marek/A-3560-2008; Zak,
   Ales/G-8318-2016; Tvrzicka, Eva/Q-6300-2016; Zeman, Miroslav/J-5281-2016
OI Jirak, Roman/0000-0002-8061-9668; Vecka, Marek/0000-0002-3269-1817; Zak,
   Ales/0000-0002-1698-6068; Tvrzicka, Eva/0000-0003-0794-8454; Zeman,
   Miroslav/0000-0001-5338-603X
FU IGA Ministry of Health of Czech Republic [NR 8806-3]
FX This work was supported by research grant IGA Ministry of Health of
   Czech Republic, NR 8806-3.
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NR 78
TC 56
Z9 59
U1 0
U2 21
PU MAGHIRA & MAAS PUBLICATIONS
PI MUNSBACH
PA MAGHIRA & MAAS S A R L, 6C, RUE GABRIEL LIPPMANN, L-5365 MUNSBACH,
   LUXEMBOURG
SN 0172-780X
EI 2354-4716
J9 NEUROENDOCRINOL LETT
JI Neuroendocrinol. Lett.
PY 2009
VL 30
IS 3
BP 387
EP 395
PG 9
WC Endocrinology & Metabolism; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology
GA 525FH
UT WOS:000272199300017
PM 19855365
DA 2025-06-11
ER

PT J
AU DeVallance, ER
   Branyan, KW
   Olfert, IM
   Pistilli, EE
   Bryner, RW
   Kelley, EE
   Frisbee, JC
   Chantler, PD
AF DeVallance, Evan R.
   Branyan, Kayla W.
   Olfert, I. Mark
   Pistilli, Emidio E.
   Bryner, Randall W.
   Kelley, Eric E.
   Frisbee, Jefferson C.
   Chantler, Paul D.
TI Chronic stress induced perivascular adipose tissue impairment of aortic
   function and the therapeutic effect of exercise
SO EXPERIMENTAL PHYSIOLOGY
LA English
DT Article
DE aldosterone; aortic stiffness; chronic stress; exercise; inflammation;
   metabolic syndrome; perivascular adipose tissue
ID CHRONIC MILD STRESS; SYMPATHETIC-NERVOUS-SYSTEM; NITRIC-OXIDE SYNTHASE;
   NF-KAPPA-B; TNF-ALPHA; ARTERIAL STIFFNESS; OXIDATIVE STRESS; VASCULAR
   DYSFUNCTION; INDEPENDENT PREDICTOR; METABOLIC SYNDROME
AB New Findings
   What is the central question of this study? Thoracic perivascular adipose tissue (tPVAT) is known to, in part, regulate aortic function: what are the effects of unpredictable chronic mild stress (UCMS) on the tPVAT regulation of aortic function and what is the role of exercise training in alleviating the potential negative actions of UCMS on tPVAT?
   What is the main finding and its importance? UCMS causes tPVAT to disrupt endothelium-dependent dilatation, increases inflammatory cytokine production and diminishes tPVAT-adiponectin. Exercise training proved efficacious in preventing tPVAT-mediated disruption of aortic function. The data support a tPVAT mechanism through which chronic stress negatively impacts vascular health, which adds to our knowledge of how psychological disorders might increase the risk of cardiovascular disease.
   Chronic stress is a major risk for cardiovascular disease. Perivascular adipose tissue (PVAT) has been shown to regulate vascular function; however, the impact of chronic stress and the comorbidity of metabolic syndrome (MetS) on thoracic (t)PVAT is unknown. Additionally, aerobic exercise training (AET) is known to combat the pathology of MetS and chronic stress, but the role of tPVAT in these actions is also unknown. Therefore, the purpose of this study was to examine the effects of unpredictable chronic mild stress (UCMS) on the tPVAT regulation of aortic function and the preventative effect of AET. Lean (LZR) and obese (OZR) Zucker rats (16-17 weeks old) were exposed to 8 weeks of UCMS with and without treadmill exercise (AET). In LZR, UCMS impaired aortic endothelium-dependent dilatation (EDD) (assessed ex vivo by wire myography) and aortic stiffness (assessed by elastic modulus) with no change in OZR subject to UCMS. However, both LZR and OZR UCMS tPVAT impaired EDD compared to respective controls. LZR and OZR subject to UCMS had higher oxidative stress production, diminished adiponectin and impaired aortic nitric oxide levels. Divergently, UCMS induced greater inflammatory cytokine production in LZR UCMS tPVAT, but not in OZR UCMS tPVAT. AET prevented the tPVAT impairment of aortic relaxation with UCMS in LZR and OZR. Additionally, AET reduced aortic stiffness in both LZR and OZR. These beneficial effects on tPVAT regulation of the aorta are likely due to AET preservation of adiponectin, reduced oxidative stress and inflammation, and enhanced nitric oxide. UCMS impaired tPVAT-regulated aortic function in LZR, and augmented MetS-induced EDD in OZR. Conversely, AET in combination with UCMS largely preserved aortic function and the tPVAT environment, in both groups.
C1 [DeVallance, Evan R.; Branyan, Kayla W.; Olfert, I. Mark; Pistilli, Emidio E.; Bryner, Randall W.; Chantler, Paul D.] West Virginia Univ, Sch Med, Dept Exercise Physiol, Morgantown, WV 26506 USA.
   [Kelley, Eric E.] West Virginia Univ, Sch Med, Dept Physiol & Pharmacol, Morgantown, WV 26506 USA.
   [Frisbee, Jefferson C.] Univ Western Ontario, Schulich Sch Med & Dent, Dept Physiol & Pharmacol, London, ON, Canada.
   [Frisbee, Jefferson C.] Univ Western Ontario, Schulich Sch Med & Dent, Dept Med Biophys, London, ON, Canada.
   [Chantler, Paul D.] West Virginia Univ, Sch Med, Dept Neurosci, Morgantown, WV 26506 USA.
C3 West Virginia University; West Virginia University; Western University
   (University of Western Ontario); Western University (University of
   Western Ontario); West Virginia University
RP Chantler, PD (corresponding author), 64 Med Ctr Dr, Morgantown, WV 26505 USA.
EM pchantler@hsc.wvu.edu
OI Frisbee, Jefferson/0000-0003-2751-0599; Chantler,
   Paul/0000-0001-6960-9728
FU American Heart Association [IRG14330015]; AHA [14PRE20380386,
   19TPA34850089]; National Institutes of Health [R01DK124510-01]; National
   Institute of General Medical Sciences of the National Institutes of
   Health [U54GM104942, 5P20GM109098]; American Heart Association (AHA)
   [19TPA34850089, 14PRE20380386] Funding Source: American Heart
   Association (AHA)
FX This studywas supported by the American Heart Association grants
   IRG14330015, predoctoral fellowship AHA(14PRE20380386) and post-doctoral
   fellowshipAHA 19TPA34850089, National Institutes of Health
   R01DK124510-01 (E.E.K.), and National Institute of General Medical
   Sciences of the National Institutes of Health(U54GM104942 and
   5P20GM109098).
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NR 81
TC 12
Z9 13
U1 0
U2 9
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0958-0670
EI 1469-445X
J9 EXP PHYSIOL
JI Exp. Physiol.
PD JUN
PY 2021
VL 106
IS 6
BP 1343
EP 1358
DI 10.1113/EP089449
EA MAY 2021
PG 16
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA SK5YT
UT WOS:000650130000001
PM 33913209
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Peña, E
   Powell, TR
   Arenas, C
   Cardoner, N
   Rebasa, P
   Luna, A
   Caixàs, A
   Rosa, A
AF Pena, Elionora
   Powell, Timothy R.
   Arenas, Concepcion
   Cardoner, Narcis
   Rebasa, Pere
   Luna, Alexis
   Caixas, Assumpta
   Rosa, Araceli
TI Longitudinal changes in telomere length in a cohort of obese patients
   submitted to bariatric surgery: a 2-year follow-up
SO SURGERY FOR OBESITY AND RELATED DISEASES
LA English
DT Article
DE Relative telomere length; Obesity; Bariatric surgery; Weight loss; T2D;
   Metabolic syndrome; Follow-up
ID BODY-MASS INDEX; WEIGHT-LOSS; DEPRESSION; INTERVENTION; ASSOCIATION;
   STRESS; ADULTS
AB Background: Telomere length (TL) is one biomarker of cell aging used to explore the effects of the environment on age-related pathologies. Obesity and high body mass index have been identified as a risk factors for shortened TL.
   Objective: To evaluate TL in different subtypes of obese patients, and to examine changes in TL in relation to weight loss after bariatric surgery.
   Setting: University Hospital in Spain.
   Methods: A cohort of 94 patients submitted to bariatric surgery were followed-up during 24 months (t(24)(m): lost to follow-up = 0%). All patients were evaluated before surgery (t(0)) and during the postoperative period (t(6m), t(12)(m), and t(24)(m)) for body mass index and metabolic variables. We assessed TL at each timepoint using quantitative polymerase chain reactions and the telomere sequence to single-copy gene sequence ratio method.
   Results: Patients with class III obesity showed significantly shorter TL at baseline than those patients with class II obesity (P = .027). No differences in TL were found between patients with or without This type 2 diabetes or metabolic syndrome. Longitudinal analysis did not show an effect of time, type of surgery, age, or sex on TL. However, a generalized estimating equation model showed that TL was shorter amongst class III obesity patients across the time course (P = .008). Comparison between patients with obesity class II and class III showed differences in TL at t(6m), (adjusted P = .024), whereby class II patients had longer TL. However, no difference was observed at the other evaluated times.
   Conclusion: Obesity severity may have negative effects on TL independently of type 2 diabetes or metabolic syndrome. Although TL is significantly longer in class II obesity patients relative to class III 6 months after bariatric surgery. This difference is not apparent after 24 months. (C) 2020 American Society for Bariatric Surgery. Published by Elsevier Inc. All rights reserved.
C1 [Pena, Elionora; Rosa, Araceli] Univ Barcelona, Fac Biol, Seccio Zool & Antropol Biol, Dept Biol Evolut Ecol & Ciencies Ambientals, Diagonal 643, Barcelona 08028, Spain.
   [Pena, Elionora; Rosa, Araceli] Univ Barcelona, Inst Biomed, Barcelona, Spain.
   [Powell, Timothy R.] Kings Coll London, Inst Psychiat Psychol & Neurosci, Social Genet & Dev Psychiat Ctr, London, England.
   [Powell, Timothy R.] Cornell Univ, Div Infect Dis, Weill Cornell Med, New York, NY USA.
   [Arenas, Concepcion] Univ Barcelona, Fac Biol, Dept Genet Microbiol & Estadist, Seccio Estadist, Barcelona, Spain.
   [Cardoner, Narcis; Rebasa, Pere; Luna, Alexis; Caixas, Assumpta] Inst Invest & Innovacio, Parc Tauli, Sabadell, Spain.
   [Cardoner, Narcis] Corp Sanitaria, Mental Hlth Dept, Parc Tauli, Sabadell, Spain.
   [Cardoner, Narcis] Hosp Univ, Dept Mental Hlth, Depress & Anxiety Program, Parc Tauli Sabadell, Barcelona, Spain.
   [Cardoner, Narcis] Univ Autonoma Barcelona, Dept Psychiat & Legal Med, Barcelona, Spain.
   [Cardoner, Narcis; Rosa, Araceli] Inst Salud Carlos III, Ctr Biomed Res Network Mental Hlth, Barcelona, Spain.
   [Rebasa, Pere; Luna, Alexis] Hosp Univ, Esofagogastr Surg Sect, Surg Dept, Parc Tauli, Sabadell, Spain.
   [Caixas, Assumpta] Univ Autonoma Barcelona, Endocrinol & Nutr Dept, Hosp Univ, Med Dept, Parc Tauli, Sabadell, Spain.
C3 University of Barcelona; University of Barcelona; University of London;
   King's College London; Cornell University; Weill Cornell Medicine;
   University of Barcelona; Autonomous University of Barcelona; Parc Tauli
   Hospital Universitari; University of Sevilla; Autonomous University of
   Barcelona; Instituto de Salud Carlos III; University of Sevilla;
   Autonomous University of Barcelona; University of Sevilla
RP Rosa, A (corresponding author), Univ Barcelona, Fac Biol, Seccio Zool & Antropol Biol, Dept Biol Evolut Ecol & Ciencies Ambientals, Diagonal 643, Barcelona 08028, Spain.; Caixàs, A (corresponding author), Hosp Univ, Endocrinol & Nutr Dept, Parc Tauli,C Parc Tauli 1, Sabadell 08208, Spain.
EM acaixas@tauli.cat; araceli.rosa@ub.edu
RI Rebasa, Pere/HTT-2204-2023; Cardoner, Narcis/AAD-5449-2022; Peña,
   Elionora/ABH-7588-2020; Rosa, Araceli/Q-2099-2016; Arenas,
   Concepcion/H-5579-2015
OI Powell, Timothy/0000-0001-9891-4895; Caixas,
   Assumpta/0000-0001-8472-9189; Cardoner, Narcis/0000-0001-9633-0888;
   Rosa, Araceli/0000-0001-6935-3785; Rebasa, Pere/0000-0003-0580-1985;
   Pena, Elionora/0000-0001-5003-5453; Arenas,
   Concepcion/0000-0002-6489-4934
FU Fundaci~o Parc Tauli [CIR2016/034]; Comissionat per a Universitats i
   Recerca of the Generalitat [2017 SGR1577]; Fundacio Montcelimar and
   Universitat de Barcelona; Medical Research Council Skills Development
   Fellowship [MR/N014863/1]; MRC [MR/N014863/1] Funding Source: UKRI
FX This study was supported by Fundaci~o Parc Tauli (Grant CIR2016/034),
   the Comissionat per a Universitats i Recerca of the Generalitat (2017
   SGR1577). E. Pena was funded by the fellowship for formative stays grant
   by the Fundacio Montcelimar and Universitat de Barcelona. T. Powell is
   funded by a Medical Research Council Skills Development Fellowship
   (MR/N014863/1).
CR [Anonymous], 2020, NUTR BOD MASS IND
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NR 32
TC 2
Z9 2
U1 0
U2 2
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1550-7289
EI 1878-7533
J9 SURG OBES RELAT DIS
JI Surg. Obes. Relat. Dis.
PD NOV
PY 2020
VL 16
IS 11
BP 1794
EP 1801
DI 10.1016/j.soard.2020.06.027
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA OH7SO
UT WOS:000582794000027
PM 32741725
DA 2025-06-11
ER

PT J
AU Akkurt, H
   Karapolat, HU
   Kirazli, Y
   Kose, T
AF Akkurt, Halil
   Karapolat, Hale U.
   Kirazli, Yesim
   Kose, Timur
TI The effects of upper extremity aerobic exercise in patients with spinal
   cord injury: a randomized controlled study
SO EUROPEAN JOURNAL OF PHYSICAL AND REHABILITATION MEDICINE
LA English
DT Article
DE Spinal cord injuries; Exercise; Ergometry
ID QUALITY-OF-LIFE; TRAINING-PROGRAMS; BODY-COMPOSITION; ARM CRANKING;
   INDIVIDUALS; PERFORMANCE; PARTICIPATION; METAANALYSIS; ERGOMETRY;
   CAPACITY
AB BACKGROUND: Immobility and secondary complications, including cardiopulmonary disease, pressure ulcers, and pain, occur in patients with spinal cord injury (SCI). These patients also have difficulty coping with the strain of daily activities. Thus, it is important for SCI patients to engage in aerobic exercise in order to be able to cope adequately with the strain of activities and SCI-related complications.
   AIM: The aim of this study was to investigate the effects of arm aerobic exercise on the parameters of cardiopulmonary function, quality of life, degree of disability, psychological state, and metabolic syndrome.
   DESIGN: This study was a single blind, randomized, controlled trial.
   SETTING: This study was conducted in a university hospital.
   POPULATION: SCI patients were randomly assigned to an intervention group (N.= 17) or a control group (N.= 16). Arm ergometer exercises (three days/week; 1.5 hours/week 50-70% pVO(2)) and general exercises (two sessions/day; 5 days/week), were assigned to the intervention group for 12 weeks. The control group was assigned general exercises only during this trial.
   METHODS: Before the rehabilitation (Week 0), after six weeks, and after the rehabilitation (Week 12), all patients were evaluated for functional status (maximal oxygen uptake [ pVO(2)], power output [ PO], and Functional Independence Measurement), pulmonary function (FEV1%, FVC%, FEV1/FVC%), quality of life (World Health Organization Measure of Quality of Life, short form, Turkish version), metabolic syndrome parameters (triglycerides, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, fasting blood sugar, waist circumference, and systolic and diastolic blood pressure), degree of disability (Craig Handicap Assessment and Reporting Technique, short form), and psychological status (Center for Epidemiologic Studies Depression Scale and Hospital Anxiety and Depression Scale).
   RESULTS: At the end of the study, increases of 39.6% and 45.4% in the pVO(2) and PO levels, respectively, were found. Additionally, no statistically significant difference was found in the intervention group after the rehabilitation compared to the levels before rehabilitation (P< 0.05). However, no statistically significant differences in functional status, quality of life, psychological state, level of disability, or metabolic syndrome parameters were found in the intervention group (P> 0.05). The control group, on the other hand, showed no clinically significant differences in any of the parameters (P> 0.05).
   CONCLUSIONS: Short-term arm aerobic exercise performed by patients with SCI improves their exercise capacities. These patients require longer rehabilitation programs to receive more benefits from aerobic exercise training.
   CLINICAL REHABILITATION IMPACT: Adding arm cranking exercise training to the rehabilitation program of patients with spinal cord injury demonstrated improved exercise capacity; however, further studies are needed to assess the effects of exercise training on other health issues.
C1 [Akkurt, Halil; Karapolat, Hale U.; Kirazli, Yesim] Ege Univ, Dept Phys Med & Rehabil, Fac Med, TR-35100 Izmir, Turkey.
   [Kose, Timur] Ege Univ, Fac Med, Dept Biostat & Med Informat, Izmir, Turkey.
C3 Ege University; Ege University
RP Karapolat, HU (corresponding author), Ege Univ, Dept Phys Med & Rehabil, Fac Med, TR-35100 Izmir, Turkey.
EM hale.karapolat@ege.edu.tr
RI Uzumcugil, Hale/LZF-2747-2025; Kirazli, Yesim/LZF-1008-2025; KOSE,
   Timur/ABH-3197-2021
OI KOSE, Timur/0000-0002-5238-9738
CR [Anonymous], SPINAL CORD INJURY R
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NR 37
TC 47
Z9 52
U1 4
U2 58
PU EDIZIONI MINERVA MEDICA
PI TURIN
PA CORSO BRAMANTE 83-85 INT JOURNALS DEPT., 10126 TURIN, ITALY
SN 1973-9087
EI 1973-9095
J9 EUR J PHYS REHAB MED
JI Eur. J. Phys. Rehabil. Med.
PD APR
PY 2017
VL 53
IS 2
BP 219
EP 227
DI 10.23736/S1973-9087.16.03804-1
PG 9
WC Rehabilitation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Rehabilitation
GA EZ8DF
UT WOS:000404953900009
PM 27824234
DA 2025-06-11
ER

PT J
AU Kario, K
   McEwen, BS
   Pickering, TG
AF Kario, K
   McEwen, BS
   Pickering, TG
TI Disasters and the heart: A review of the effects of earthquake-induced
   stress on cardiovascular disease
SO HYPERTENSION RESEARCH
LA English
DT Review
DE stress; hypertension; cardiovascular disease; risk factor
ID HANSHIN-AWAJI EARTHQUAKE; ACUTE MYOCARDIAL-INFARCTION; ELDERLY
   HYPERTENSIVE PATIENTS; WHITE-COAT HYPERTENSION; AMBULATORY
   BLOOD-PRESSURE; FACTOR-VII HYPERACTIVITY; ENDOTHELIAL-CELL DAMAGE;
   MEDICAL-SCHOOL COHORT; ACTIVATED FACTOR-VII; ACUTE RISK-FACTORS
AB There is growing evidence that stress contributes to cardiovascular disease. Chronic stress contributes to the atherosclerotic process through increased allostatic load, which is mediated by the neuroendocrine and immune systems (sympathetic nervous system and hypothalamus-pituitary adrenal axis) and related chronic risk factors (insulin resistance syndrome, hypertension, diabetes, and hyperlipidemia). In addition, acute stress can trigger cardiovascular events predominantly through sympathetic nervous activation and potentiation of acute risk factors (blood pressure increase, endothelial cell dysfunction, increased blood viscosity, and platelet and hemostatic activation). Earthquakes provide a good example of naturally occurring acute and chronic stress, and in this review we focus mainly on the effects of the Hanshin-Awaji earthquake on the cardiovascular system. The Hanshin-Awaji earthquake resulted in a 3-fold increase of myocardial infarctions in people living close to the epicenter, particularly in women, with most of the increase occurring in nighttime-onset events. There was also a near doubling in the frequency of strokes. These effects may be mediated by changes in hemostatic factors, as demonstrated by an increase of D-dimer, von Willebrand factor, and tissue-type plasminogen activator (tPA) antigen. Blood pressure also increased after the earthquake, and was prolonged for several weeks in patients with microalbuminuria.
C1 Jichi Med Sch, Dept Cardiol, Minami Kawachi, Tochigi 3290498, Japan.
   Mt Sinai Sch Med, Behav & Integrat Cardiol Program, Zena & Michael A Wiener Cardiovasc Ctr, New York, NY USA.
   Harold & Margaret Milliken Hatch Lab Neuroendocri, New York, NY USA.
C3 Jichi Medical University; Icahn School of Medicine at Mount Sinai
RP Jichi Med Sch, Dept Cardiol, 3311-1 Yakushiji, Minami Kawachi, Tochigi 3290498, Japan.
EM kkario@jichi.ac.jp
RI McEwen, Bruce/Z-1630-2019
FU NHLBI NIH HHS [P01 HL047540, HL-47540] Funding Source: Medline
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NR 109
TC 160
Z9 181
U1 0
U2 19
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0916-9636
EI 1348-4214
J9 HYPERTENS RES
JI Hypertens. Res.
PD MAY
PY 2003
VL 26
IS 5
BP 355
EP 367
DI 10.1291/hypres.26.355
PG 13
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Cardiovascular System & Cardiology
GA 698YJ
UT WOS:000184027600002
PM 12887126
OA Bronze
DA 2025-06-11
ER

PT J
AU Alvarez-Monell, A
   Subias-Gusils, A
   Mariné-Casadó, R
   Belda, X
   Gagliano, H
   Pozo, OJ
   Boqué, N
   Caimari, A
   Armario, A
   Solanas, M
   Escorihuela, RM
AF Alvarez-Monell, Adam
   Subias-Gusils, Alex
   Marine-Casado, Roger
   Belda, Xavier
   Gagliano, Humberto
   Pozo, Oscar J.
   Boque, Noemi
   Caimari, Antoni
   Armario, Antonio
   Solanas, Montserrat
   Escorihuela, Rosa M.
TI Restricted cafeteria feeding and treadmill exercise improved body
   composition, metabolic profile and exploratory behavior in obese male
   rats
SO SCIENTIFIC REPORTS
LA English
DT Article
ID PITUITARY-ADRENAL AXIS; CORTICOTROPIN-RELEASING FACTOR; HIGH-FAT; HPA
   AXIS; INSULIN-RESISTANCE; LOCOMOTOR-ACTIVITY; PHYSICAL-ACTIVITY; DIET;
   STRESS; CORTICOSTERONE
AB The aim of this study was to evaluate, in male Long-Evans rats, whether a restricted-cafeteria diet (CAFR), based on a 30% calorie restriction vs continuous ad libitum cafeteria (CAF) fed animals, administered alone or in combination with moderate treadmill exercise (12 m/min, 35 min, 5 days/week for 8 weeks), was able to ameliorate obesity and the associated risk factors induced by CAF feeding for 18 weeks and to examine the changes in circadian locomotor activity, hypothalamic-pituitary-adrenal (HPA) axis functionality, and stress response elicited by this dietary pattern. In addition to the expected increase in body weight and adiposity, and the development of metabolic dysregulations compatible with Metabolic Syndrome, CAF intake resulted in a sedentary profile assessed by the home-cage activity test, reduced baseline HPA axis activity through decreased corticosterone levels, and boosted exploratory behavior. Both CAFR alone and in combination with exercise reduced abdominal adiposity and hypercholesterolemia compared to CAF. Exercise increased baseline locomotor activity in the home-cage in all dietary groups, boosted exploratory behavior in STD and CAF, partially decreased anxiety-like behavior in CAF and CAFR, but did not affect HPA axis-related parameters.
C1 [Alvarez-Monell, Adam; Solanas, Montserrat] Univ Autonoma Barcelona, Fac Med, Dept Cell Biol Physiol & Immunol, Med Physiol Unit, Bellaterra 08193, Spain.
   [Alvarez-Monell, Adam; Subias-Gusils, Alex; Belda, Xavier; Gagliano, Humberto; Armario, Antonio; Solanas, Montserrat; Escorihuela, Rosa M.] Univ Autonoma Barcelona, Inst Neurociencies, Bellaterra 08193, Spain.
   [Subias-Gusils, Alex] Univ Autonoma Barcelona, Dept Psiquiatria & Med Legal, Unitat Psicol Med, Bellaterra 08193, Spain.
   [Marine-Casado, Roger; Boque, Noemi; Caimari, Antoni] Ctr Tecnol Catalunya, Biotechnol Area & Technol Unit Nutr & Hlth, Eurecat, Reus 43204, Spain.
   [Belda, Xavier; Gagliano, Humberto; Armario, Antonio; Escorihuela, Rosa M.] Univ Autonoma Barcelona, Fac Biosci, Dept Cell Biol Physiol & Immunol, Anim Physiol Unit, Bellaterra 08193, Spain.
   [Pozo, Oscar J.] IMIM Hosp Mar Med Res Inst, Gastroesophageal Carcinogenesis Grp, Carrer Doctor Aiguader 88, Barcelona 08003, Spain.
C3 Autonomous University of Barcelona; Autonomous University of Barcelona;
   Autonomous University of Barcelona; Autonomous University of Barcelona;
   Hospital del Mar Research Institute
RP Solanas, M (corresponding author), Univ Autonoma Barcelona, Fac Med, Dept Cell Biol Physiol & Immunol, Med Physiol Unit, Bellaterra 08193, Spain.; Solanas, M; Escorihuela, RM (corresponding author), Univ Autonoma Barcelona, Inst Neurociencies, Bellaterra 08193, Spain.; Escorihuela, RM (corresponding author), Univ Autonoma Barcelona, Fac Biosci, Dept Cell Biol Physiol & Immunol, Anim Physiol Unit, Bellaterra 08193, Spain.
EM Montserrat.Solanas@uab.cat; Rosamaria.Escorihuela@uab.cat
RI Gagliano, Humberto/C-9695-2011; Armario, Antonio/C-9267-2011; Solanas,
   Montserrat/AGN-1896-2022; Pozo, Oscar/I-1615-2019; Belda,
   Xavier/C-9103-2011; Escorihuela, Rosa M/L-4524-2014
OI Subias-Gusils, Alex/0000-0001-6981-7383; Belda,
   Xavier/0000-0003-0374-9546; Escorihuela, Rosa M/0000-0001-9368-5173;
   Marine-Casado, Roger/0000-0002-0924-4920; Alvarez-Monell,
   Adam/0000-0003-4806-3361; SOLANAS GARCIA, MONTSERRAT/0000-0003-2949-1344
FU Spanish Ministerio de Economia, Industria y Competitividad
   [PSI2016-77234-R]; Universitat Autonoma de Barcelona [PIF-UAB2018];
   Ministerio de Ciencia e Innovacion [BES-2017-081939]; Catalan Government
FX This research was funded by the Spanish Ministerio de Economia,
   Industria y Competitividad, grant number PSI2016-77234-R. A.A-M. is
   granted by the Universitat Autonoma de Barcelona, grant PIF-UAB2018.
   A.S.-G. is granted by the Ministerio de Ciencia e Innovacion, grant
   number BES-2017-081939. This work was also financially supported by the
   Catalan Government through the funding grant ACCIO-EURECAT. The funding
   sources had no involvement in study design, collection, analysis and
   interpretation of data, the writing of the report and the decision to
   submit the article for publication.
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NR 78
TC 4
Z9 4
U1 4
U2 12
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD NOV 15
PY 2022
VL 12
IS 1
AR 19545
DI 10.1038/s41598-022-23464-7
PG 15
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 6H0KC
UT WOS:000885139000062
PM 36379981
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Warolin, J
   Coenen, KR
   Kantor, JL
   Whitaker, LE
   Wang, L
   Acra, SA
   Roberts, LJ
   Buchowski, MS
AF Warolin, J.
   Coenen, K. R.
   Kantor, J. L.
   Whitaker, L. E.
   Wang, L.
   Acra, S. A.
   Roberts, L. J., II
   Buchowski, M. S.
TI The relationship of oxidative stress, adiposity and metabolic risk
   factors in healthy Black and White American youth
SO PEDIATRIC OBESITY
LA English
DT Article
DE Adiposity; isoprostane; metabolic syndrome
ID HOMEOSTASIS MODEL ASSESSMENT; CORONARY-HEART-DISEASE;
   INSULIN-RESISTANCE; OBESE CHILDREN; VISCERAL FAT; SENSITIVITY;
   ADOLESCENTS; SERUM; COMPLICATIONS; ISOPROSTANE
AB BackgroundOxidative stress is elevated in obese youth, but less is known regarding racial disparities in the relationship of oxidative stress with metabolic risk factors.
   ObjectivesTo determine the relationship between oxidative stress and metabolic risk factors, adiposity, leptin, adiponectin and cardiovascular fitness (VO2PEAK) in healthy African American and White American youth.
   MethodsA marker of oxidative stress (F-2-isoprostane), validated markers of metabolic risk factors, fitness and body composition were measured in African American (n=82) and White American (n=76) youth (8-17 years old) recruited over a range of BMI percentiles (4th to 99th).
   ResultsF(2)-isoprostane concentration was positively correlated with percentage body fat (r=0.198) and percentage truncal fat (r=0.173), but was not different between African American and White American males and females (P=0.208). African American youth had significantly higher mean systolic and diastolic blood pressure (P=0.023 and P=0.011, respectively), body weight, BMI percentile and Tanner stage. After adjusting for gender, age, BMI and Tanner stage, African American youth varied from White Americans in the association of F-2-isoprostane with diastolic blood pressure (P=0.047), but not with systolic blood pressure, triglycerides, VO2PEAK or homeostatic model assessment for insulin resistance (all P>0.05).
   ConclusionsOxidative stress, as measured by urinary F-2-isoprostane concentrations, was positively associated with percent body fat and truncal fat in youth. Oxidative stress levels were similar among African American and White American youth. Among markers of the metabolic syndrome, a significant difference between African American and White American youth was demonstrated only in the association of oxidative stress with diastolic blood pressure.
C1 [Warolin, J.; Kantor, J. L.; Acra, S. A.] Vanderbilt Univ, Med Ctr, Div Gastroenterol, Dept Pediat, Nashville, TN 37232 USA.
   [Coenen, K. R.; Whitaker, L. E.; Buchowski, M. S.] Vanderbilt Univ, Med Ctr, Div Gastroenterol, Dept Med, Nashville, TN 37232 USA.
   [Wang, L.] Vanderbilt Univ, Med Ctr, Dept Biostat, Nashville, TN 37232 USA.
   [Roberts, L. J., II] Vanderbilt Univ, Med Ctr, Dept Clin Pharmacol, Dept Med, Nashville, TN 37232 USA.
C3 Vanderbilt University; Vanderbilt University; Vanderbilt University;
   Vanderbilt University
RP Buchowski, MS (corresponding author), Vanderbilt Univ, Med Ctr, A-4103 MCN,1161 21st Ave South, Nashville, TN 37232 USA.
EM maciej.buchowski@vanderbilt.edu
OI Buchowski, Maciej/0000-0002-0566-1743
FU NIH [RO1HL082988, DK20593]; National Center for Research Resources at
   the National Center for Advancing Translational Sciences [UL1
   RR024975-01, 2 UL1 TR000445-06]; Vanderbilt Research Training in
   Diabetes and Endocrinology grant [NIH T32 DK07061-35]; NIDDK training
   grant [NIH T32 DK007673-17]; NIH MERIT Award [GM42056]
FX This work was supported by grants from the NIH (RO1HL082988) and the
   National Center for Research Resources, Grant UL1 RR024975-01, and is
   now at the National Center for Advancing Translational Sciences, Grant 2
   UL1 TR000445-06. KRC was supported by a Vanderbilt Research Training in
   Diabetes and Endocrinology grant (NIH T32 DK07061-35) and JW by a NIDDK
   training grant (NIH T32 DK007673-17). Additional support came from an
   NIH MERIT Award (GM42056) awarded to LJR. The content is solely the
   responsibility of the authors and does not necessarily represent the
   official views of the National Institute of Health. Hormone, lipid and
   isoprostane assays were performed in the core laboratories of the
   Vanderbilt Diabetes Research and Training Center supported by NIH grant
   DK20593. We would like to thank Stephane Daphnis, Denise Dunlap, Cindy
   Dorminy, Natalie Meade, Elizabeth Provenzano and Daniel Short for their
   contributions to the acquisition of the data for this study.
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NR 51
TC 55
Z9 63
U1 0
U2 8
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2047-6310
EI 2047-6302
J9 PEDIATR OBES
JI Pediatr. Obes.
PD FEB
PY 2014
VL 9
IS 1
BP 43
EP 52
DI 10.1111/j.2047-6310.2012.00135.x
PG 10
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA 292VY
UT WOS:000329932000009
PM 23296459
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Mann, JK
   Lutzker, L
   Holm, SM
   Margolis, HG
   Neophytou, AM
   Eisen, EA
   Costello, S
   Tyner, T
   Holland, N
   Tindula, G
   Prunicki, M
   Nadeau, K
   Noth, EM
   Lurmann, F
   Hammond, SK
   Balmes, JR
AF Mann, Jennifer K.
   Lutzker, Liza
   Holm, Stephanie M.
   Margolis, Helene G.
   Neophytou, Andreas M.
   Eisen, Ellen A.
   Costello, Sadie
   Tyner, Tim
   Holland, Nina
   Tindula, Gwen
   Prunicki, Mary
   Nadeau, Kari
   Noth, Elizabeth M.
   Lurmann, Fred
   Hammond, S. Katharine
   Balmes, John R.
TI Traffic-related air pollution is associated with glucose dysregulation,
   blood pressure, and oxidative stress in children
SO ENVIRONMENTAL RESEARCH
LA English
DT Article
DE Children; Metabolic syndrome; HbA1c; Oxidative stress; Traffic-related
   air pollution; Polycyclic aromatic hydrocarbons
ID POLYCYCLIC AROMATIC-HYDROCARBONS; INTIMA-MEDIA THICKNESS; LONG-TERM
   EXPOSURE; BODY-MASS INDEX; INSULIN-RESISTANCE; LIPID-PEROXIDATION; US
   CHILDREN; CHILDHOOD; OBESITY; INFLAMMATION
AB Background: Metabolic syndrome increases the risk of cardiovascular disease in adults. Antecedents likely begin in childhood and whether childhood exposure to air pollution plays a contributory role is not well understood. Objectives: To assess whether children's exposure to air pollution is associated with markers of risk for metabolic syndrome and oxidative stress, a hypothesized mediator of air pollution-related health effects.
   Methods: We studied 299 children (ages 6-8) living in the Fresno, CA area. At a study center visit, questionnaire and biomarker data were collected. Outcomes included hemoglobin A1c (HbA1c), urinary 8-isoprostane, systolic blood pressure (SBP), and BMI. Individual-level exposure estimates for a set of four pollutants that are constituents of traffic-related air pollution (TRAP) - the sum of 4-, 5-, and 6-ring polycyclic aromatic hydrocarbon compounds (PAH456), NO2, elemental carbon, and fine particulate matter (PM2.5) - were modeled at the primary residential location for 1-day lag, and 1-week, 1-month, 3-month, 6-month, and 1-year averages prior to each participant's visit date. Generalized additive models were used to estimate associations between each air pollutant exposure and outcome.
   Results: The study population was 53% male, 80% Latinx, 11% Black and largely low-income (6% were White and 3% were Asian/Pacific Islander). HbA1c percentage was associated with longer-term increases in TRAP; for example a 4.42 ng/m(3) increase in 6-month average PAH456 was associated with a 0.07% increase (95% CI: 0.01, 0.14) and a 3.62 mu g/m(3) increase in 6-month average PM2.5 was associated with a 0.06% increase (95% CI: 0.01, 0.10). The influence of air pollutants on blood pressure was strongest at 3 months; for example, a 6.2 ppb increase in 3-month average NO2 was associated with a 9.4 mmHg increase in SBP (95% CI: 2.8, 15.9). TRAP concentrations were not significantly associated with anthropometric or adipokine measures. Short-term TRAP exposure averages were significantly associated with creatinine-adjusted urinary 8-isoprostane.
   Discussion: Our results suggest that both short- and longer-term estimated individual-level outdoor residential exposures to several traffic-related air pollutants, including ambient PAHs, are associated with biomarkers of risk for metabolic syndrome and oxidative stress in children.
C1 [Mann, Jennifer K.; Lutzker, Liza; Holm, Stephanie M.; Neophytou, Andreas M.; Eisen, Ellen A.; Costello, Sadie; Holland, Nina; Tindula, Gwen; Noth, Elizabeth M.; Hammond, S. Katharine; Balmes, John R.] Univ Calif Berkeley, Sch Publ Hlth, Div Environm Hlth Sci, Berkeley, CA 94720 USA.
   [Margolis, Helene G.] Univ Calif Davis, Dept Internal Med, Davis, CA 95616 USA.
   [Neophytou, Andreas M.] Colorado State Univ, Dept Environm & Radiol Hlth Sci, Ft Collins, CO 80523 USA.
   [Tyner, Tim] Univ Calif San Francisco Fresno, Fresno, CA USA.
   [Tyner, Tim] Cent Calif Asthma Collaborat, Fresno, CA USA.
   [Prunicki, Mary; Nadeau, Kari] Stanford Univ, Sean N Parker Ctr Allergy & Asthma Res, Palo Alto, CA 94304 USA.
   [Lurmann, Fred] Sonoma Technol, Petaluma, CA USA.
   [Holm, Stephanie M.; Balmes, John R.] Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA.
C3 University of California System; University of California Berkeley;
   University of California System; University of California Davis;
   Colorado State University System; Colorado State University Fort
   Collins; University of California System; University of California San
   Francisco; University of California San Francisco at Fresno; Stanford
   University; Sonoma Technology, Inc.; University of California System;
   University of California San Francisco
RP Balmes, JR (corresponding author), Univ Calif Berkeley, Sch Publ Hlth, Div Environm Hlth Sci, Berkeley, CA 94720 USA.
EM jbalmes@berkeley.edu
RI Lutzker, Liza/MAI-3669-2025; Neophytou, Andreas/MTE-0808-2025; Balmes,
   John/L-6281-2019; Holm, Stephanie/AAC-7456-2020
OI Lutzker, Elizabeth/0000-0003-0611-0158; Costello,
   Sadie/0000-0001-6181-5666
FU Children's Health and Air Pollution Study (CHAPS), an NIH/EPA [EPA:
   RD83543501, NIH: ES022849, NIH: F31ES0277510]; National Institute for
   Occupational Safety and Health [T42OH008429] Funding Source: NIH
   RePORTER; National Institute of Environmental Health Sciences
   [R24ES030888] Funding Source: NIH RePORTER
FX This research was supported by the Children's Health and Air Pollution
   Study (CHAPS), an NIH/EPA-funded Children's Environmental Health
   Research Center (EPA: RD83543501, NIH: ES022849) and an additional grant
   (NIH: F31ES0277510). The content is solely the responsibility of the
   authors and does not necessarily represent the official views of the
   National Institutes of Health. Gwen Tindula received a Student/New
   Investigator Travel Award of $750.00 to attend and present at the 2019
   Environmental Mutagenesis and Genomics Society (EMGS) meeting in
   Washington DC from September 19-23.
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   Zuk M., 2013, THESIS U CALIFORNIA
NR 60
TC 30
Z9 33
U1 0
U2 36
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0013-9351
EI 1096-0953
J9 ENVIRON RES
JI Environ. Res.
PD APR
PY 2021
VL 195
AR 110870
DI 10.1016/j.envres.2021.110870
EA FEB 2021
PG 10
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA RM0BZ
UT WOS:000639328800149
PM 33587949
OA Green Submitted, Green Accepted
DA 2025-06-11
ER

PT J
AU Fan, HX
   Wang, YL
   Ren, ZY
   Liu, XC
   Zhao, JQ
   Yuan, YL
   Fei, XN
   Song, XS
   Wang, FQ
   Liang, B
AF Fan, Hongxuan
   Wang, Yongle
   Ren, Zhaoyu
   Liu, Xuchang
   Zhao, Jianqi
   Yuan, Yalin
   Fei, Xiaoning
   Song, Xiaosu
   Wang, Fengqin
   Liang, Bin
TI Mediterranean diet lowers all-cause and cardiovascular mortality for
   patients with metabolic syndrome
SO DIABETOLOGY & METABOLIC SYNDROME
LA English
DT Article
ID INSULIN-RESISTANCE; SEDENTARY BEHAVIOR; PHYSICAL-ACTIVITY;
   UNITED-STATES; DEPRESSION; CARBOHYDRATE; PREVALENCE; OBESITY; ADULTS;
   TRENDS
AB A Mediterranean-style diet (MED) can promote people lengthen the span of life and avoid atherosclerotic cardiovascular disease (ASCVD) in primary prevention. Metabolic syndrome (MetS) can significantly reduce life expectancy and increase the risk of ASCVD. However, few studies have focused on the role of the Mediterranean diet in patients with MetS. Participants in the National Health and Nutrition Examination Survey (NHANES) with MetS (N = 8301) from 2007 to 2018 were examined. A 9-point evaluation scorewas used to measure the degree of adherence to the MED diet. In order to compare the various levels of adherence to the MED diet and the effects of the specific MED diet components on all-cause and cardiovascular mortality, Cox regression models were utilized. Among the 8301 participants with MetS, about 13.0% (1080 of 8301) died after a median follow-up of 6.3 years. In this study, participants with MetS with adherence to high-quality and moderate-quality Mediterranean diet were significantly associated with lower all-cause mortality as well as cardiovascular mortality during the follow-up period. Futhermore, in joint analysis of the Mediterranean diet and sedentary behavior or depression, we found that high-quality or moderate-quality Mediterranean diet could attenuate, even reverse the adverse effects of sedentary behavior and depression on all-cause and cardiovascular mortality in participants with MetS. Among the components of the MED diet, greater intakes of vegetables, legumes, nuts and high MUFA/SFA ratio were significantly associated with lower all-cause mortality and greater vegetables intake was significantly associated with lower cardiovascular mortality, while more red/processed meat intake was significantly associated with higher cardiovascular mortality in participants with MetS.
C1 [Fan, Hongxuan; Ren, Zhaoyu; Zhao, Jianqi; Yuan, Yalin; Song, Xiaosu; Liang, Bin] Shanxi Med Univ, Dept Cardiol, Hosp 2, 382 Wuyi Rd, Taiyuan 030001, Shanxi, Peoples R China.
   [Wang, Yongle] Shanxi Med Univ, Dept Neurol, Hosp 1, 85 Jiefang South Rd, Taiyuan 030001, Shanxi, Peoples R China.
   [Liu, Xuchang] Shanxi Med Univ, Dept Urol, Hosp 1, 85 Jiefang South Rd, Taiyuan 030001, Shanxi, Peoples R China.
   [Fei, Xiaoning] Shanxi Med Univ, 56 Xinjian South Rd, Taiyuan 030001, Shanxi, Peoples R China.
   [Wang, Fengqin] Yangquan First Peoples Hosp, Dept Cardiol, 167 South St, Yangquan 030001, Shanxi, Peoples R China.
C3 Shanxi Medical University; Shanxi Medical University; Shanxi Medical
   University; Shanxi Medical University
RP Liang, B (corresponding author), Shanxi Med Univ, Dept Cardiol, Hosp 2, 382 Wuyi Rd, Taiyuan 030001, Shanxi, Peoples R China.
EM tyliangbin@163.com
RI Li, Xuming/JLM-6754-2023; Liang, Bin/JHU-0581-2023
OI Fan, Hongxuan/0000-0002-1234-544X
FU National Natural Science Foundation of China [82270494]; Fund Program
   for the Scientific Activities of Selected Returned Overseas
   Professionals in Shanxi Province [20220043]; Shanxi Graduate Education
   Innovation Project [2022Y386]
FX This work was supported by National Natural Science Foundation of China
   (grant number 82270494), Fund Program for the Scientific Activities of
   Selected Returned Overseas Professionals in Shanxi Province
   (No.20220043) and Shanxi Graduate Education Innovation Project (grant
   number 2022Y386).
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NR 46
TC 29
Z9 31
U1 4
U2 16
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1758-5996
J9 DIABETOL METAB SYNDR
JI Diabetol. Metab. Syndr.
PD MAY 23
PY 2023
VL 15
IS 1
AR 107
DI 10.1186/s13098-023-01052-7
PG 16
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA H2IM1
UT WOS:000994252500003
PM 37221569
OA gold
DA 2025-06-11
ER

PT J
AU Rani, V
   Deep, G
   Singh, RK
   Palle, K
   Yadav, UCS
AF Rani, Vibha
   Deep, Gagan
   Singh, Rakesh K.
   Palle, Komaraiah
   Yadav, Umesh C. S.
TI Oxidative stress and metabolic disorders: Pathogenesis and therapeutic
   strategies
SO LIFE SCIENCES
LA English
DT Review
DE Oxidative stress; Antioxidant; Metabolic disorders; Inflammation;
   Diabetes; Cardiovascular diseases; Insulin resistance; Carcinogenesis;
   Phytochemicals
ID FORKHEAD TRANSCRIPTION FACTORS; CYCLIN-DEPENDENT KINASE-4; BETA-CELL
   PROLIFERATION; REACTIVE OXYGEN; ADIPOCYTE DIFFERENTIATION; HISTONE
   MODIFICATIONS; DIABETES-MELLITUS; NITRIC-OXIDE; VASCULAR COMPLICATIONS;
   INSULIN-RESISTANCE
AB Increased body weight and metabolic disorder including insulin resistance, type 2 diabetes and cardiovascular complications together constitute metabolic syndrome. The pathogenesis of metabolic syndrome involves multitude of factors. A number of studies however indicate, with some conformity, that oxidative stress along with chronic inflammatory condition pave the way for the development of metabolic diseases. Oxidative stress, a state of lost balance between the oxidative and anti-oxidative systems of the cells and tissues, results in the over production of oxidative free radicals and reactive oxygen species (ROS). Excessive ROS generated could attack the cellular proteins, lipids and nucleic acids leading to cellular dysfunction including loss of energy metabolism, altered cell signalling and cell cycle control, genetic mutations, altered cellular transport mechanisms and overall decreased biological activity, immune activation and inflammation. In addition, nutritional stress such as that caused by high fat high carbohydrate diet also promotes oxidative stress as evident by increased lipid peroxidation products, protein carbonylation, and decreased antioxidant system and reduced glutathione (GSH) levels. These changes lead to initiation of pathogenicmilieu and development of several chronic diseases. Studies suggest that in obese person oxidative stress and chronic inflammation are the important underlying factors that lead to development of pathologies such as carcinogenesis, obesity, diabetes, and cardiovascular diseases through altered cellular and nuclear mechanisms, including impaired DNA damage repair and cell cycle regulation. Here wediscuss the aspects ofmetabolic disorders-induced oxidative stress inmajor pathological conditions and strategies for their prevention and therapy. (C) 2016 Elsevier Inc. All rights reserved.
C1 [Rani, Vibha] JayPee Inst Informat Technol, Dept Biotechnol, A-10,Sect 62, Noida 201307, UP, India.
   [Deep, Gagan] Univ Colorado Denver, Skaggs Sch Pharm & Pharmaceut Sci, 12850 E Montview Blvd, Aurora, CO 80045 USA.
   [Singh, Rakesh K.] Florida State Univ, Coll Med, Translat Sci Lab, 1115 West Call St, Tallahassee, FL 32306 USA.
   [Palle, Komaraiah] USA Mitchell Canc Inst, Dept Oncol Sci, 1660 Spring Hill Ave, Mobile, AL 36604 USA.
   [Yadav, Umesh C. S.] Cent Univ Gujarat, Sch Life Sci, Metab Disorder & Inflammatory Pathol Lab, Sect 30, Gandhinagar 382030, India.
C3 Jaypee Institute of Information Technology (JIIT); Children's Hospital
   Colorado; University of Colorado System; University of Colorado Anschutz
   Medical Campus; State University System of Florida; Florida State
   University; Central University of Gujarat
RP Yadav, UCS (corresponding author), Cent Univ Gujarat, Sch Life Sci, Metab Disorder & Inflammatory Pathol Lab, Sect 30, Gandhinagar 382030, India.
EM vibha.rani@jiit.ac.in; Gagan.Deep@ucdenver.edu;
   rakesh.singh@med.fsu.edu; kpalle@health.southalabama.edu;
   umeshyadav@cug.ac.in
RI Deep, Gagan/H-1853-2012; Singh, Prof R K/GPG-0335-2022
FU Department of Science and Technology (DST), Government of India
   [SR/S2/RJN-102/2012]; Department of Biotechnology (DBT), Government of
   India [BT/PR3978/17/766/2011]; Abraham A. Mitchell Cancer Research
   Scholar Endowment Grant
FX Award of Ramanujan Fellowship from Department of Science and Technology
   (DST), Government of India SR/S2/RJN-102/2012 (UCSY); fund support from
   Department of Biotechnology (DBT), Government of India
   BT/PR3978/17/766/2011 (VR) and Abraham A. Mitchell Cancer Research
   Scholar Endowment Grant (KP) are acknowledged. Assistance of Drs.
   Chinnadurai Mani and Neha Atale for assisting with preparation of the
   manuscript is also acknowledged.
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NR 154
TC 839
Z9 909
U1 17
U2 403
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0024-3205
EI 1879-0631
J9 LIFE SCI
JI Life Sci.
PD MAR 1
PY 2016
VL 148
BP 183
EP 193
DI 10.1016/j.lfs.2016.02.002
PG 11
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA DG0XM
UT WOS:000371789300023
PM 26851532
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Sanghez, V
   Razzoli, M
   Carobbio, S
   Campbell, M
   McCallum, J
   Cero, C
   Ceresini, G
   Cabassi, A
   Govoni, P
   Franceschini, P
   de Santis, V
   Gurney, A
   Ninkovic, I
   Parmigiani, S
   Palanza, P
   Vidal-Puig, A
   Bartolomucci, A
AF Sanghez, Valentina
   Razzoli, Maria
   Carobbio, Stefania
   Campbell, Mark
   McCallum, Jacob
   Cero, Cheryl
   Ceresini, Graziano
   Cabassi, Aderville
   Govoni, Paolo
   Franceschini, Paolo
   de Santis, Valentina
   Gurney, Allison
   Ninkovic, Ivana
   Parmigiani, Stefano
   Palanza, Paola
   Vidal-Puig, Antonio
   Bartolomucci, Alessandro
TI Psychosocial stress induces hyperphagia and exacerbates diet-induced
   insulin resistance and the manifestations of the Metabolic Syndrome
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE Social stress; Dominance; Subiordination; Type 2 diabetes; Laptin;
   Adiponectin; Glucose tolerance test; Hyperphagia
ID CHRONIC SOCIAL STRESS; HIGH-FAT DIET; INDUCED OBESITY; VISCERAL OBESITY;
   LIFE EVENTS; FOOD-INTAKE; MALE-MICE; VULNERABILITY; DEFEAT; HEALTH
AB Stress and hypercaloric food are recognized risk factors for obesity, Metabolic Syndrome (MetS) and Type 2 Diabetes (T2D). Given the complexity of these metabolic processes and the unavailability of animal models, there is poor understanding of their underlying mechanisms. We established a model of chronic psychosocial stress in which subordinate mice are vulnerable to weight gain while dominant mice are resilient. Subordinate mice fed a standard diet showed marked hyperphagia, high leptin, low adiponectin, and dyslipidemia. Despite these molecular signatures of MetS and T2D, subordinate mice fed a standard diet were still euglycemic. We hypothesized that stress predisposes subordinate mice to develop T2D when synergizing with other risk factors. High fat diet aggravated dyslipidemia and the MetS thus causing a pre-diabetes-like state in subordinate mice. Contrary to subordinates, dominant mice were fully protected from stress-induced metabolic disorders when fed both a standard- and a high fat-diet. Dominant mice showed a hyperphagic response that was similar to subordinate but, unlike subordinates, showed a significant increase in VO2, VCO2, and respiratory exchange ratio when compared to control mice. Overall, we demonstrated a robust stress- and social status-dependent effect on the development of MetS and T2D and provided insights on the physiological mechanisms. Our results are reminiscent of the effect of the individual socioeconomic status on human health and provide an animal model to study the underlying molecular mechanisms. (C) 2013 Elsevier Ltd. All rights reserved.
C1 [Sanghez, Valentina; Razzoli, Maria; McCallum, Jacob; Cero, Cheryl; Gurney, Allison; Ninkovic, Ivana; Bartolomucci, Alessandro] Univ Minnesota, Dept Integrat Biol & Physiol, Minneapolis, MN 55455 USA.
   [Sanghez, Valentina; Franceschini, Paolo; de Santis, Valentina; Parmigiani, Stefano; Palanza, Paola] Univ Parma, Dept Neurosci, I-43100 Parma, Italy.
   [Carobbio, Stefania; Campbell, Mark; Vidal-Puig, Antonio] Univ Cambridge, Addenbrookes Hosp, Metab Res Labs, Cambridge CB2 2QQ, England.
   [Ceresini, Graziano; Cabassi, Aderville] Univ Parma, Dept Clin & Expt Med, I-43100 Parma, Italy.
   [Govoni, Paolo] Univ Parma, Dept Biomed Sci, I-43100 Parma, Italy.
C3 University of Minnesota System; University of Minnesota Twin Cities;
   University of Parma; University of Cambridge; Cambridge University
   Hospitals NHS Foundation Trust; Addenbrooke's Hospital; University of
   Parma; University Hospital of Parma; University of Parma
RP Bartolomucci, A (corresponding author), Univ Minnesota, Dept Integrat Biol & Physiol, Minneapolis, MN 55455 USA.
EM abartolo@umn.edu
RI Cero, Cheryl/JVZ-0936-2024; Bartolomucci, Alessandro/MFI-6219-2025;
   carobbio, stefania/E-7095-2018
OI Bartolomucci, Alessandro/0000-0001-6439-8829; PARMIGIANI,
   STEFANO/0000-0002-6658-2029; Sanghez, Valentina/0000-0002-4131-7480;
   Vidal-Puig, Antonio/0000-0003-4220-9577; RAZZOLI,
   Maria/0000-0001-5911-4633; Cero, Cheryl/0000-0003-0513-8669
FU University of Parma; MMF; UofMN Medical School; MRC; MRC DU; Cambridge
   Phenomics Centre; MRC [MC_UU_12012/2, G0600717, MC_G0802535, G0802051]
   Funding Source: UKRI
FX This work was supported in part by University of Parma, MMF, and UofMN
   Medical School to AB; MRC Program grant, MRC DU and Cambridge Phenomics
   Centre to TVP. Authors wish to thanks the Imaging Center, University of
   Minnesota, William Engeland and Carley Karsten, University of Minnesota,
   and Sergio Rodriguez Cuenca, University of Cambridge for technical
   assistance and Elizabeth Seaquist, University of Minnesota, for critical
   reading of an early version of this manuscript. Authors declare no
   conflict of interest.
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NR 59
TC 53
Z9 57
U1 0
U2 21
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD DEC
PY 2013
VL 38
IS 12
BP 2933
EP 2942
DI 10.1016/j.psyneuen.2013.07.022
PG 10
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA AA0YX
UT WOS:000330824400012
PM 24060458
DA 2025-06-11
ER

PT J
AU Fond, G
   Faugere, M
   Richieri, R
   Cermolacce, M
   Korchia, T
   Micoulaud-Franchi, JA
   de Verville, PLS
   Boyer, L
   Lançon, C
AF Fond, G.
   Faugere, M.
   Richieri, R.
   Cermolacce, M.
   Korchia, T.
   Micoulaud-Franchi, J. A.
   de Verville, P. L. Sunhary
   Boyer, L.
   Lancon, C.
TI Depressive symptoms and chronic peripheral inflammation are associated
   with impaired functional remission in schizophrenia independently of
   psychotic remissionl
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Psychiatry; Schizophrenia; Depression; Inflammation; Remission
ID C-REACTIVE PROTEIN; COGNITIVE IMPAIRMENT; DISORDERS; SCALE
AB Background: While psychotic remission in schizophrenia (SZ) has been defined by consensus and associated with a rank of clinical predictive factors, there is a lack of data of factors associated with functional remission.
   Objectives: To identify clinical and biological factors associated with impaired functional remission in a non selected chronic stabilized SZ outpatients.
   Methods: This study was a cross-sectional study carried out on all admitted SZ stabilized outpatients in an academic daily care psychiatric hospital. Functional remission was defined by a global assessment of functioning score >61. Psychotic remission was defined according to international criteria. Depression was assessed with the Calgary Depression Rating scale for Schizophrenia. Sociodemographic variables, tobacco status, clozapine treatment and obesity were reported. Chronic peripheral inflammation was defined by a highly sensitive C reactive protein serum level >3 mg/L and metabolic syndrome according to international recommendations.
   Results: 273 patients were included, among them 51 (18.7%) were classified in the functional remission group. In the multivariate analysis, higher rate of functional remission was associated with psychotic remission (adjusted Odd ratio = 18.2, p <0.001), lower depressive symptoms (aOR=0.8, p = 0.018) and lower peripheral inflammation (aOR=0.4, p = 0.046). No association of functional remission with age, gender, illness duration, second generation antipsychotics, clozapine treatment, tobacco smoking, obesity or metabolic syndrome has been found.
   Conclusion: Depressive symptoms and chronic peripheral inflammation are associated with impaired functional remission in SZ independently of psychotic remission. Future intervention studies should determine if improving depressive symptoms and chronic peripheral inflammation may improve SZ patients reaching functional remission.
C1 [Fond, G.; Faugere, M.; Cermolacce, M.; Korchia, T.; de Verville, P. L. Sunhary; Boyer, L.; Lancon, C.] Hop Univ Marseille, Dept Psychiat, F-13005 Marseille, France.
   [Fond, G.; Faugere, M.; Richieri, R.; de Verville, P. L. Sunhary; Boyer, L.; Lancon, C.] CEReSS Hlth Serv Res & Qual Life Ctr, EA 3279, 27 Blvd Jean Moulin, F-13005 Marseille, France.
   [Micoulaud-Franchi, J. A.] Univ Bordeaux, CHU Pellegrin, USR CNRS SANPSY 3413, Bordeaux, France.
C3 Aix-Marseille Universite; Assistance Publique-Hopitaux de Marseille;
   Aix-Marseille Universite; Centre National de la Recherche Scientifique
   (CNRS); CNRS - National Institute for Biology (INSB); CHU Bordeaux;
   Universite de Bordeaux
RP Fond, G (corresponding author), Aix Marseille Univ, EA 3279, CEReSS Ctr Etud & Rech Serv Sante & Qualite Vie, Fac Med,Sect Timone,AP HM, 27 Blvd Jean Moulin, F-13005 Marseille, France.
EM guillaume.fond@ap-hm.fr
RI Faugere, Melanie/JCP-3459-2023; richieri, raphaelle/E-4707-2015; Fond,
   Guillaume/D-7646-2011; Boyer, Laurent/E-5728-2016
OI Faugere, Melanie/0000-0001-5567-8650; Korchia, Theo/0000-0002-6392-9322;
   RICHIERI, Raphaelle/0000-0002-3901-7016; Boyer,
   Laurent/0000-0003-1229-6622
FU Hopitaux Universitaires de Marseille (HUM)
FX This study was supported by the Hopitaux Universitaires de Marseille
   (HUM).
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NR 37
TC 8
Z9 8
U1 0
U2 5
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD FEB 1
PY 2021
VL 280
BP 267
EP 271
DI 10.1016/j.jad.2020.11.046
PN A
PG 5
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA PH8ZE
UT WOS:000600692600036
PM 33220563
DA 2025-06-11
ER

PT J
AU Patt, M
   Karkossa, I
   Krieg, L
   Massier, L
   Makki, K
   Tabei, S
   Karlas, T
   Dietrich, A
   Gericke, M
   Stumvoll, M
   Blüher, M
   von Bergen, M
   Schubert, K
   Kovacs, P
   Chakaroun, RM
AF Patt, Marie
   Karkossa, Isabel
   Krieg, Laura
   Massier, Lucas
   Makki, Kassem
   Tabei, Shirin
   Karlas, Thomas
   Dietrich, Arne
   Gericke, Martin
   Stumvoll, Michael
   Bluher, Matthias
   von Bergen, Martin
   Schubert, Kristin
   Kovacs, Peter
   Chakaroun, Rima M.
TI FGF21 and its underlying adipose tissue-liver axis inform
   cardiometabolic burden and improvement in obesity after metabolic
   surgery
SO EBIOMEDICINE
LA English
DT Article
ID GROWTH-FACTOR 21; Y GASTRIC BYPASS; BARIATRIC SURGERY; GENE-EXPRESSION;
   PLASMA FGF21; SUGAR INTAKE; WEIGHT-LOSS; GLUCOSE; REGULATOR; SECRETION
AB Background This research investigates the determinants of circulating FGF21 levels in a cohort reflecting metabolic disease progression, examining the associations of circulating FGF21 with morphology and function of adipose tissue (AT), and with metabolic adjustments following metabolic surgery. Methods We measured serum FGF21 in 678 individuals cross-sectionally and in 189 undergoing metabolic surgery longitudinally. Relationships between FGF21 levels, AT histology, transcriptomes and proteomes, cardiometabolic risk factors, and post-surgery metabolic adjustments were assessed using univariate and multivariate analyses, causal mediation analysis, and network integration of AT transcriptomes and proteomes. Findings FGF21 levels were linked to central adiposity, subclinical inflammation, insulin resistance, and cardiometabolic risk, and were driven by circulating leptin and liver enzymes. Higher FGF21 were linked with AT dysfunction reflected in fi bro-in fl ammatory and lipid dysmetabolism pathways. Specifically, visceral AT inflammation was tied to both FGF21 elevation and liver dysfunction. Post-surgery, FGF21 peaked transitorily at three months. Mediation analysis highlighted an underlying increased AT catabolic state with elevated free fatty acids (FFA), contributing to higher liver stress and FGF21 levels (total effect of free fatty acids on FGF21 levels: 0.38, p < 0.01; proportion mediation via liver 32%, p < 0.01). In line with this, histological AT fi brosis linked with less pronounced FGF21 responses and reduced fat loss post-surgery (FFA and visceral AT fi brosis: rho = - 0.31, p = 0.030; FFA and fat-mass loss: rho = 0.17, p = 0.020). Interpretation FGF21 reflects the liver's disproportionate metabolic stress response in both central adiposity and after metabolic surgery, with its dynamics reflecting an AT-liver crosstalk.
C1 [Massier, Lucas; Stumvoll, Michael; Bluher, Matthias; Kovacs, Peter; Chakaroun, Rima M.] Univ Leipzig, Med Dept Endocrinol Nephrol 3, Med Ctr, Leipzig, Germany.
   [Schubert, Kristin] UFZ, Helmholtz Ctr Environm Res, Dept Mol Syst Biol, Leipzig, Germany.
   Karolinska Inst, Dept Med H7, Stockholm, Sweden.
   Univ Lyon, INSA Lyon, INSERM, Lyon, France.
   [Tabei, Shirin] Univ Lubeck, Inst Endocrinol & Diabet, Lubeck, Germany.
   Univ Lubeck, Ctr Brain Behav & Metab CBBM, Lubeck, Germany.
   Univ Leipzig, Med Dept 2, Div Gastroenterol, Med Ctr, Leipzig, Germany.
   Univ Leipzig, Med Ctr, Dept Visceral Transplant Thorac & Vasc Surg, Leipzig, Germany.
   Univ Leipzig, Inst Anat, Leipzig, Germany.
   [Bluher, Matthias] Univ Leipzig, Helmholtz Inst Metab Obes & Vasc Res HI MAG, Helmholtz Zentrum Munchen, Leipzig, Germany.
   [Stumvoll, Michael; Bluher, Matthias] Univ Hosp Leipzig, Leipzig, Germany.
   [von Bergen, Martin] Univ Leipzig, Inst Biochem, Leipzig, Germany.
   [von Bergen, Martin] German Ctr Integrat Biodivers Res iDiv, Leipzig, Germany.
   [Kovacs, Peter] Deutsch Zent Diabetesforsch eV, Neuherberg, Germany.
   [Chakaroun, Rima M.] Univ Gothenburg, Dept Mol & Clin Med, Wallenberg Lab, Gothenburg, Sweden.
   [Chakaroun, Rima M.] Univ Gothenburg, Sahlgrenska Ctr Cardiovasc & Metab Res, Gothenburg, Sweden.
C3 Leipzig University; Helmholtz Association; Helmholtz Center for
   Environmental Research (UFZ); Karolinska Institutet; Institut National
   des Sciences Appliquees de Lyon - INSA Lyon; Institut National de la
   Sante et de la Recherche Medicale (Inserm); University of Lubeck;
   University of Lubeck; Leipzig University; Leipzig University; Leipzig
   University; Helmholtz Association; Helmholtz-Center Munich - German
   Research Center for Environmental Health; Leipzig University; Leipzig
   University; Leipzig University; German Research Foundation (DFG); German
   Centre for Integrative Biodiversity Research (iDiv); University of
   Gothenburg; University of Gothenburg
RP Chakaroun, RM (corresponding author), Univ Leipzig, Med Dept Endocrinol Nephrol 3, Med Ctr, Leipzig, Germany.
EM rima.chakaroun@wlab.gu.se
RI Gericke, Martin/AAI-8637-2020; Kovacs, Peter/KCK-1454-2024; Stumvoll,
   Michael/ABE-1121-2021; Massier, Lucas/AEE-9781-2022; Karkossa,
   Isabel/AAH-1809-2021; von Bergen, Martin/D-7960-2011; makki,
   kassem/HTN-0263-2023; Karlas, Thomas/I-1782-2019; Chakaroun,
   Rima/LGY-8314-2024; Schubert, Kristin/AAB-6438-2020
OI Karlas, Thomas/0000-0002-8109-8526
FU Deutsche Forschungsgemeinschaft (DFG, German Research Foundation)
   [209933838, CRC1382, 530364326]; Medical Faculty, University of Leipzig;
   Federal Ministry of Education and Research (BMBF) , Germany; European
   Union; Novo Nordisk Foundation;  [CRC 1052];  [FKZ: 01EO1501]; 
   [HEALTH-F4-2012-305312]
FX This work was supported by the Deutsche Forschungsgemeinschaft (DFG,
   German Research Foundation) through CRC 1052, project number 209933838,
   CRC1382 and a Walther-Benjamin Fellowship and by a junior research grant
   by the Medical Faculty, University of Leipzig, and by the Federal
   Ministry of Education and Research (BMBF) , Germany, FKZ: 01EO1501. Part
   of this work was supported by the European Union's Seventh Framework
   Program for research, technological development and demonstration under
   grant agreement HEALTH-F4-2012-305312 and by the CRC1382 and the Novo
   Nordisk Foundation and by the Deutsche Forschungsgemeinschaft (DFG,
   German Research foundation) project number 530364326.
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NR 57
TC 0
Z9 0
U1 2
U2 2
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2352-3964
J9 EBIOMEDICINE
JI EBioMedicine
PD DEC
PY 2024
VL 110
AR 105458
DI 10.1016/j.ebiom.2024.105458
EA NOV 2024
PG 16
WC Medicine, General & Internal; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Research & Experimental Medicine
GA O2O2N
UT WOS:001369580200001
PM 39608059
OA gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Huber, M
   Heiduschka, P
   Ziemssen, F
   Bolbrinker, J
   Kreutz, R
AF Huber, Matthias
   Heiduschka, Peter
   Ziemssen, Focke
   Bolbrinker, Juliane
   Kreutz, Reinhold
TI Microangiopathy and visual deficits characterize the retinopathy of a
   spontaneously hypertensive rat model with type 2 diabetes and metabolic
   syndrome
SO HYPERTENSION RESEARCH
LA English
DT Article
DE electroretinography; histology; metabolic syndrome; rat; retina
ID ROD PHOTORECEPTOR DYSFUNCTION; DIETARY FLAXSEED MEAL; ANIMAL-MODEL;
   RETINAL ARTERIOLES; INSULIN-RESISTANCE; OXIDATIVE STRESS; MULLER CELLS;
   STREPTOZOTOCIN; COMPLICATIONS; NEPHROPATHY
AB Retinopathy has been increasing in prevalence as a consequence of type 2 diabetes and a cluster of coexisting risk factors characterized as the metabolic syndrome. However, the combined effects of these conditions on the retina are poorly understood. Therefore, we focused on the spontaneously hypertensive corpulent rat (SHR/N-cp), a model with type 2 diabetes, obesity and features of the metabolic syndrome to characterize retinal changes at a structural and functional level. SHR/N-cp males at 4 and 8 months of age were used in this study. Metabolic parameters and blood pressure were measured by standard methods. Morphology was investigated by histological techniques supplemented by nicotinamide adenine dinucleotide phosphate-diaphorase staining of whole mounts and fluorescein angiography to analyze the retinal vasculature. The in vivo function of the retina was examined by electroretinography (ERG). Obese SHR/N-cp rats were hypertensive and showed significant increases in body weight, serum levels of glucose, triglycerides, total cholesterol and urinary glucose excretion compared with lean controls (P<0.01 for each). Histology indicated an overall intact integrity of the retina and aspects of microangiopathy in obese SHR/N-cp rats. ERG revealed intact processing of light signals but significantly decreased amplitudes of b-waves for all (P<0.01) and of a-waves for some examined light intensities (P<0.05). Oscillatory potentials were significantly protracted (P<0.01), whereas amplitudes were not reduced. Microangiopathy and electroretinographic deficits combine to produce an early non-proliferative retinopathy phenotype in the obese SHR/N-cp rats. Thus, this model represents a valuable experimental tool to obtain further insights into the mechanisms of retinopathy in the context of obesity, type 2 diabetes and metabolic syndrome. Hypertension Research (2011) 34, 103-112; doi: 10.1038/hr.2010.168; published online 7 October 2010
C1 [Huber, Matthias; Bolbrinker, Juliane; Kreutz, Reinhold] Charite, Inst Clin Pharmacol & Toxicol, Charite Ctr Therapieforsch, D-10117 Berlin, Germany.
   [Heiduschka, Peter] Univ Tubingen, Dept Augenheilkunde, Univ Klinikums Tubingen, Sekt Expt Vitreoretinale Chirurg, Tubingen, Germany.
   [Ziemssen, Focke] Univ Tubingen, Ctr Ophthalmol, Univ Augenklin Tubingen, Tubingen, Germany.
C3 Berlin Institute of Health; Free University of Berlin; Humboldt
   University of Berlin; Charite Universitatsmedizin Berlin; Eberhard Karls
   University of Tubingen; Eberhard Karls University Hospital; Eberhard
   Karls University of Tubingen; Eberhard Karls University Hospital
RP Huber, M (corresponding author), Charite, Inst Clin Pharmacol & Toxicol, Charite Ctr Therapieforsch, CharitePl 1, D-10117 Berlin, Germany.
EM matthias.huber@charite.de
RI Kreutz, Reinhold/AEV-0507-2022; Ziemssen, Focke/B-9564-2009; Heiduschka,
   Peter/AAX-3882-2021
OI Bolbrinker, Juliane/0000-0002-0812-8549; Kreutz,
   Reinhold/0000-0002-4818-211X
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NR 65
TC 7
Z9 7
U1 0
U2 3
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0916-9636
EI 1348-4214
J9 HYPERTENS RES
JI Hypertens. Res.
PD JAN
PY 2011
VL 34
IS 1
BP 103
EP 112
DI 10.1038/hr.2010.168
PG 10
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 702TP
UT WOS:000285919100021
PM 20927114
OA Bronze
DA 2025-06-11
ER

PT J
AU Uzunlulu, M
   Oguz, A
   Yorulmaz, E
AF Uzunlulu, Mchmet
   Oguz, Aytekin
   Yorulmaz, Elif
TI The effect of carvedilol on metabolic parameters in patients with
   metabolic syndrome
SO INTERNATIONAL HEART JOURNAL
LA English
DT Article
DE metabolic syndrome; hypertension; carvedilol; doxazosin; atenolol
ID ELEVATED OXIDATIVE STRESS; INSULIN SENSITIVITY; DIABETES-MELLITUS;
   SERUM-LIPIDS; HYPERTENSION; PARTICLES; BLOCKERS; ATENOLOL; GLUCOSE;
   OBESITY
AB The objective of the present study was to explore the effect of carvedilol treatment on metabolic parameters in patients with metabolic syndrome. A total of 77 patients >= 20 years of age (59 females, 18 mates, mean age, 52.3 +/- 10.3) with stage 1 hypertension who fulfilled at least 3 of the metabolic syndrome criteria proposed by NCEP-ATP III were included in this prospective, randomized, controlled study. Patients were randomly assigned to receive daily treatment with carvedilol (n = 27, 12.5 mg/day orally for the first 2 days and 25 mg/day thereafter), atenolol (n = 26, 50 mg/day orally), or doxazosin (n = 24, 2 mg/day orally) for 90 days. Doses were doubled at the end of the 3rd week in patients whose blood pressure was inadequately controlled and amlodipine 10 mg was added to the treatment if the target blood pressure was still not reached at the end of week 6. The biochemical parameters and insulin sensitivity based on the HOMA-IR model were evaluated at baseline and at the end of treatment. Similar reductions in systolic and diastolic blood pressure were observed in all groups (P > 0.05). A significant decrease in HDL cholesterol levels occurred in the doxazosin and atenolol groups compared to the carvedilol group (percent change: -5.6 +/- 13.5 and -8 +/- 9.8 versus -0.1 +/- 12.2, respectively; P < 0.05) and a significant increase in apolipoprotein A1 level was observed in the carvedilol group compared to the doxazosin and atenolol groups (percent change: +4.3 +/- 9.6 versus -0.5 +/- 10.6 and -2.3 +/- 6.6, respectively; P < 0.05). There were no significant differences among the groups with respect to other parameters. It is concluded antihypertensive treatment with carvedilol in patients with metabolic syndrome effectively reduces blood pressure without adversely affecting metabolic parameters.
C1 Goztepe Training & Res Hosp, Dept Internal Med, TR-34843 Istanbul, Turkey.
C3 Istanbul Goztepe Training & Research Hospital
RP Uzunlulu, M (corresponding author), Goztepe Training & Res Hosp, Dept Internal Med, Altaycesme Mahallesi,Sarigul Sokak,Kuralkan Sites, TR-34843 Istanbul, Turkey.
RI Oguz, Aytekin/AAJ-2732-2021
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NR 27
TC 16
Z9 16
U1 0
U2 7
PU INT HEART JOURNAL ASSOC
PI TOKYO
PA UNIV TOKYO, GRADUATE SCHOOL MEDICINE, DEPT CARDIOVASCULAR MEDICINE,
   HONGO 7-3-1, BUNKYO-KU, TOKYO, 113-8655, JAPAN
SN 1349-2365
EI 1349-3299
J9 INT HEART J
JI Int. Heart J.
PD MAY
PY 2006
VL 47
IS 3
BP 421
EP 430
DI 10.1536/ihj.47.421
PG 10
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 070XH
UT WOS:000239559300011
PM 16823248
OA Bronze
DA 2025-06-11
ER

PT J
AU Giangregorio, F
   Mosconi, E
   Debellis, MG
   Provini, S
   Esposito, C
   Garolfi, M
   Oraka, S
   Kaloudi, O
   Mustafazade, G
   Marín-Baselga, R
   Tung-Chen, Y
AF Giangregorio, Francesco
   Mosconi, Emilio
   Debellis, Maria Grazia
   Provini, Stella
   Esposito, Ciro
   Garolfi, Matteo
   Oraka, Simona
   Kaloudi, Olga
   Mustafazade, Gunel
   Marin-Baselga, Raquel
   Tung-Chen, Yale
TI A Systematic Review of Metabolic Syndrome: Key Correlated Pathologies
   and Non-Invasive Diagnostic Approaches
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Review
DE metabolic syndrome; non-invasive assessment; liver fibrosis;
   cardiovascular disease; hepatic steatosis
ID NONALCOHOLIC FATTY LIVER; CHRONIC HEART-FAILURE; PLATELET RATIO INDEX;
   MAGNETIC-RESONANCE ELASTOGRAPHY; CARDIOVASCULAR RISK-FACTORS; ALL-CAUSE
   MORTALITY; INSULIN-RESISTANCE; ASPARTATE-AMINOTRANSFERASE; HEPATIC
   STEATOSIS; FIBROSIS-4 INDEX
AB Background and Objectives: Metabolic syndrome (MetS) is a condition marked by a complex array of physiological, biochemical, and metabolic abnormalities, including central obesity, insulin resistance, high blood pressure, and dyslipidemia (characterized by elevated triglycerides and reduced levels of high-density lipoproteins). The pathogenesis develops from the accumulation of lipid droplets in the hepatocyte (steatosis). This accumulation, in genetically predisposed subjects and with other external stimuli (intestinal dysbiosis, high caloric diet, physical inactivity, stress), activates the production of pro-inflammatory molecules, alter autophagy, and turn on the activity of hepatic stellate cells (HSCs), provoking the low grade chronic inflammation and the fibrosis. This syndrome is associated with a significantly increased risk of developing type 2 diabetes mellitus (T2D), cardiovascular diseases (CVD), vascular, renal, pneumologic, rheumatological, sexual, cutaneous syndromes and overall mortality, with the risk rising five- to seven-fold for T2DM, three-fold for CVD, and one and a half-fold for all-cause mortality. The purpose of this narrative review is to examine metabolic syndrome as a "systemic disease" and its interaction with major internal medicine conditions such as CVD, diabetes, renal failure, and respiratory failure. It is essential for internal medicine practitioners to approach this widespread condition in a "holistic" rather than a fragmented manner, particularly in Western countries. Additionally, it is important to be aware of the non-invasive tools available for assessing this condition. Materials and Methods: We conducted an exhaustive search on PubMed up to July 2024, focusing on terms related to metabolic syndrome and other pathologies (heart, Lung (COPD, asthma, pulmonary hypertension, OSAS) and kidney failure, vascular, rheumatological (osteoarthritis, rheumatoid arthritis), endocrinological, sexual pathologies and neoplastic risks. The review was managed in accordance with the PRISMA statement. Finally, we selected 300 studies (233 papers for the first search strategy and 67 for the second one). Our review included studies that provided insights into metabolic syndrome and non-invasive techniques for evaluating liver fibrosis and steatosis. Studies that were not conducted on humans, were published in languages other than English, or did not assess changes related to heart failure were excluded. Results: The findings revealed a clear correlation between metabolic syndrome and all the pathologies above described, indicating that non-invasive assessments of hepatic fibrosis and steatosis could potentially serve as markers for the severity and progression of the diseases. Conclusions: Metabolic syndrome is a multisystem disorder that impacts organs beyond the liver and disrupts the functioning of various organs. Notably, it is linked to a higher incidence of cardiovascular diseases, independent of traditional cardiovascular risk factors. Non-invasive assessments of hepatic fibrosis and fibrosis allow clinicians to evaluate cardiovascular risk. Additionally, the ability to assess liver steatosis may open new diagnostic, therapeutic, and prognostic avenues for managing metabolic syndrome and its complications, particularly cardiovascular disease, which is the leading cause of death in these patients.
C1 [Giangregorio, Francesco; Mosconi, Emilio; Debellis, Maria Grazia; Provini, Stella; Esposito, Ciro; Garolfi, Matteo; Oraka, Simona; Kaloudi, Olga; Mustafazade, Gunel] Codogno Hosp, Dept Internal Med, Via Marconi 1, I-26900 Codogno, Italy.
   [Marin-Baselga, Raquel; Tung-Chen, Yale] Hosp Univ La Paz, Dept Internal Med, Paseo Castellana 241, Madrid 28046, Spain.
C3 Hospital Universitario La Paz
RP Tung-Chen, Y (corresponding author), Hosp Univ La Paz, Dept Internal Med, Paseo Castellana 241, Madrid 28046, Spain.
EM francesco.giangregorio@asst-lodi.it; emilio.mosconi@asst-lodi.it;
   mariagrazia.debellis@asst-lodi.it; stella.provini@ast-lodi.it;
   ciro.esposito@asst-lodi.it; matteo.garolfi@asst-lodi.it;
   simona.oraka@gmail.com; gunelmustafazade01@gmail.com;
   raquelzgz14@gmail.com; yale.tung@salud.madrid.org
RI tung chen, yale/AFS-6904-2022; Giangregorio, Francesco/K-6082-2013
OI Giangregorio, Francesco/0000-0002-5347-0183
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NR 300
TC 4
Z9 4
U1 2
U2 4
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD OCT
PY 2024
VL 13
IS 19
AR 5880
DI 10.3390/jcm13195880
PG 37
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA I7I5G
UT WOS:001331958900001
PM 39407941
OA gold
DA 2025-06-11
ER

PT J
AU Doghri, Y
   Chetaneau, F
   Rhimi, M
   Kriaa, A
   Lalanne, V
   Thorin, C
   Maguin, E
   Mallem, MY
   Desfontis, JC
AF Doghri, Yosra
   Chetaneau, Fabien
   Rhimi, Moez
   Kriaa, Aicha
   Lalanne, Valerie
   Thorin, Chantal
   Maguin, Emmanuelle
   Mallem, M. Yassine
   Desfontis, Jean-Claude
TI Sildenafil citrate long-term treatment effects on cardiovascular
   reactivity in a SHR experimental model of metabolic syndrome
SO PLOS ONE
LA English
DT Article
ID SPONTANEOUSLY HYPERTENSIVE-RATS; DIET-INDUCED OBESITY; GUT MICROBIOTA;
   HIGH-FAT; ENDOTHELIAL DYSFUNCTION; VASORELAXATION; RESISTANCE; AORTA
AB Much evidence indicates that metabolic syndrome is strongly correlated with a decrease in nitric oxide and an increase in oxidative stress leading to cardiovascular alterations. In recent years, gut microbiota has emerged as a new contributor to the metabolic syndrome establishment and associated cardiovascular diseases, but the underlying mechanisms remain unclear. We hypothesized that a positive modulation of cyclic guanosine monophosphate (cGMP) pathway, through phosphodiesterase type 5 (PDE5) inhibition could prevent cardiovascular alterations and gut dysbiosis that may be associated to metabolic syndrome. Spontaneously hypertensive rats (SHR) were randomly divided into 4 groups: control, cafeteria diet (CD) and sildenafil citrate treated groups (5mg/kg per os) were given either a CD or a standard chow diet for 10 weeks. Body weight, arterial blood pressure and glucose tolerance test were monitored. At the 10th week, cardiac inotropy and coronary perfusion pressure were evaluated on isolated heart according to Langendorff method. Cumulative concentration response curves to phenylephrine and acetylcholine were determined on thoracic aorta rings for vascular reactivity evaluation. Faecal samples were collected for the gut microbiota analysis. Compared to the control group, CD-fed rats showed a significant increase in body weight gain, arterial blood pressure and were glucose intolerant. This group showed also a decrease in beta-adrenoceptor-induced cardiac inotropy and coronary vasodilation. Gut microbiota analysis revealed a significant reduction in the abundance of Lactobocillus spp in cafeteria diet-fed rats when compared to the control ones. Sildenafil citrate long-term treatment decreased weight gain and arterial blood pressure, improved coronary vasodilation and reduced a 1-adrenoceptor-induced vasoconstriction in CD group. However, it did not reverse gut dysbiosis induced by chronic CD feeding. These results suggest that cGMP pathway targeting may be a potential therapeutic strategy for the management of the metabolic syndrome and associated cardiovascular disorders.
C1 [Doghri, Yosra; Chetaneau, Fabien; Lalanne, Valerie; Thorin, Chantal; Mallem, M. Yassine; Desfontis, Jean-Claude] Oniris, Coll Vet Med Food Sci & Engn, Atlanpole La Chantrerie, UPSP NP3 2017 B6146,Nutr Pathophysiol & Pharmacol, Route Gachet,5 BP, Nantes, France.
   [Rhimi, Moez; Kriaa, Aicha; Maguin, Emmanuelle] Univ Paris Saclay, UMR Micalis 1319, INRA, AgroParisTech,Microbiota Interact Human & Anim Te, Jouy En Josas, France.
C3 Ecole Nationale Veterinaire, Agroalimentaire et de l'Alimentation
   Nantes-Atlantique; AgroParisTech; INRAE; Universite Paris Saclay
RP Doghri, Y (corresponding author), Oniris, Coll Vet Med Food Sci & Engn, Atlanpole La Chantrerie, UPSP NP3 2017 B6146,Nutr Pathophysiol & Pharmacol, Route Gachet,5 BP, Nantes, France.
EM yosra.doghri@oniris-nantes.fr
RI Kriaa, Aisha/HLH-2445-2023; Desfontis, Jean-Claude/AAA-1623-2022;
   MALLEM, yassine/AHD-1776-2022
OI Maguin, Emmanuelle/0000-0001-5452-3382; MALLEM,
   yassine/0000-0001-5867-580X; Desfontis, Jean-Claude/0000-0002-1124-7979;
   RHIMI, Moez/0000-0001-8067-6526
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NR 51
TC 8
Z9 8
U1 0
U2 5
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD NOV 7
PY 2019
VL 14
IS 11
AR e0223914
DI 10.1371/journal.pone.0223914
PG 17
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA LN1GV
UT WOS:000532694400015
PM 31697707
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Doghri, Y
   Dubreil, L
   Lalanne, V
   Hélissen, O
   Fleurisson, R
   Thorin, C
   Desfontis, JC
   Mallem, MY
AF Doghri, Yosra
   Dubreil, Laurence
   Lalanne, Valerie
   Helissen, Ophelie
   Fleurisson, Romain
   Thorin, Chantal
   Desfontis, Jean-Claude
   Mallem, M. Yassine
TI Soluble guanylate cyclase chronic stimulation effects on cardiovascular
   reactivity in cafeteria diet-induced rat model of metabolic syndrome
SO EUROPEAN JOURNAL OF PHARMACOLOGY
LA English
DT Article
DE Metabolic syndrome; sGC stimulation; SHR; Cafeteria diet; Cardiovascular
   reactivity
ID SPONTANEOUSLY HYPERTENSIVE-RATS; ENDOTHELIAL DYSFUNCTION; OXIDATIVE
   STRESS; BLOOD-PRESSURE; VASCULAR FUNCTION; THORACIC AORTA; INSULIN
   ACTION; BAY 41-2272; OBESE; RESISTANCE
AB Metabolic syndrome is linked to an increased risk of cardiovascular complications by a mechanism involving mainly decreased nitric oxide (NO) bioavailability and impaired NO-soluble guanylate cyclase (sGC)-cyclic guanosine monophosphate (cGMP) signalling (NO-sGC-cGMP). To further develop this scientific point, this study aimed to investigate the effects of long-term treatment with BAY 41-2272 (a sGC stimulator) on cardiovascular reactivity of spontaneously hypertensive rats (SHR) as a model of metabolic syndrome. SHR were randomly divided into 3 groups: control group, cafeteria diet (CD)-fed group and CD-fed group treated daily with BAY 41-2272 (5 mg/kg) by gastric gavage for 12 weeks. In vivo measurements of body weight, abdominal circumference, blood pressure and glucose tolerance test were performed. At the end of the feeding period, ex vivo cumulative concentration-response curves were performed on isolated perfused heart (isoproterenol (0.1 nM - 1 mu M)) and thoracic aorta (phenylephrine (1 nM-10 mu M), acetylcholine (1 nM-10 mu M), and sodium nitroprusside (SNP) (0.1 nM-0.1 mu M)). We showed that chronic CD feeding induced abdominal obesity, hypertriglyceridemia, glucose intolerance and exacerbated arterial hypertension in SHR. Compared to control group, CD-fed group showed a decrease in beta-adrenoceptor-induced cardiac inotropy, in coronary perfusion pressure and in aortic contraction to phenylephrine. While relaxing effects of acetylcholine and SNP were unchanged. BAY 41-2272 long-term treatment markedly prevented arterial hypertension development and glucose intolerance, enhanced the alpha(1)-adrenoceptor-induced vasoconstriction, and restored cardiac inotropy and coronary vasodilation. These findings suggest that BAY 41-2272 may be a potential novel drug for preventing metabolic and cardiovascular complications of metabolic syndrome.
C1 [Doghri, Yosra; Lalanne, Valerie; Helissen, Ophelie; Thorin, Chantal; Desfontis, Jean-Claude; Mallem, M. Yassine] Nantes Atlantic Coll Vet Med Food Sci & Engn, Oniris, UPSP NP3 2017 B146, Nutr Pathophysiol & Pharmacol, F-44307 Nantes 03, France.
   [Dubreil, Laurence; Fleurisson, Romain] Nantes Atlantic Coll Vet Med Food Sci & Engn, Oniris, UMR PAnTher 703 INRA Oniris Anim Pathophysiol & B, F-44307 Nantes 03, France.
C3 Ecole Nationale Veterinaire, Agroalimentaire et de l'Alimentation
   Nantes-Atlantique; Ecole Nationale Veterinaire, Agroalimentaire et de
   l'Alimentation Nantes-Atlantique; INRAE
RP Mallem, MY (corresponding author), Nantes Atlantic Coll Vet Med Food Sci & Engn, Oniris, UPSP NP3 2017 B146, Nutr Pathophysiol & Pharmacol, F-44307 Nantes 03, France.
EM yassine.mallem@oniris-nantes.fr
RI Desfontis, Jean-Claude/AAA-1623-2022; MALLEM, yassine/AHD-1776-2022
OI Desfontis, Jean-Claude/0000-0002-1124-7979; MALLEM,
   yassine/0000-0001-5867-580X
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NR 54
TC 4
Z9 4
U1 0
U2 10
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0014-2999
EI 1879-0712
J9 EUR J PHARMACOL
JI Eur. J. Pharmacol.
PD MAY 15
PY 2021
VL 899
AR 173978.
DI 10.1016/j.ejphar.2021.173978
EA MAR 2021
PG 10
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA RO9SI
UT WOS:000641378500009
PM 33691164
OA Green Published
DA 2025-06-11
ER

PT J
AU Lasserre, AM
   Strippoli, MPF
   Glaus, J
   Gholam-Rezaee, M
   Vandeleur, CL
   Castelao, E
   Marques-Vidal, P
   Waeber, G
   Vollenweider, P
   Preisig, M
AF Lasserre, A. M.
   Strippoli, M-P F.
   Glaus, J.
   Gholam-Rezaee, M.
   Vandeleur, C. L.
   Castelao, E.
   Marques-Vidal, P.
   Waeber, G.
   Vollenweider, P.
   Preisig, M.
TI Prospective associations of depression subtypes with cardio-metabolic
   risk factors in the general population
SO MOLECULAR PSYCHIATRY
LA English
DT Article
ID TYPE-2 DIABETES-MELLITUS; MAJOR DEPRESSION; DIAGNOSTIC INTERVIEW;
   CARDIOVASCULAR-DISEASE; ATYPICAL FEATURES; DISORDERS; METAANALYSIS;
   CYTOKINES; PREDICTS; OBESITY
AB The mechanisms and temporal sequence underlying the association between major depressive disorder (MDD) and cardio-metabolic diseases are still poorly understood. Recent research suggests subtyping depression to study the mechanisms underlying its association with biological correlates. Accordingly, our aims were to (1) assess the prospective associations of the atypical, melancholic and unspecified subtypes of MDD with changes of fasting glucose, high-density lipoprotein-cholesterol, triglycerides, systolic blood pressure and the incidence of the metabolic syndrome, (2) determine the potential mediating role of inflammatory marker or adipokine concentrations, eating behaviors and changes in waist circumference during follow-up. Data stemmed from CoLaus|PsyCoLaus, a prospective cohort study including 35-66-year-old randomly selected residents of an urban area. Among the Caucasian participants who underwent the physical and psychiatric baseline evaluations, 2813 (87% participation rate) also accepted the physical follow-up exam (mean follow-up duration = 5.5 years). Symptoms of mental disorders were elicited using a semi-structured interview. The atypical MDD subtype, and only this subtype, was prospectively associated with a higher incidence of the metabolic syndrome (OR = 2.49; 95% CI 1.30-4.77), a steeper increase of waist circumference (beta = 2.41; 95% CI 1.19-3.63) and independently of this, with a steeper increase of the fasting glucose level (beta = 131; 95% CI 38-225) during follow-up. These associations were not attributable to or mediated by inflammatory marker or adipokine concentrations, eating behaviors, comorbid psychiatric disorders or lifestyle factors. Accordingly, our results further support the subtyping of MDD and highlight the particular need for prevention and treatment of metabolic consequences in patients with atypical MDD.
C1 [Lasserre, A. M.; Strippoli, M-P F.; Glaus, J.; Gholam-Rezaee, M.; Vandeleur, C. L.; Castelao, E.; Preisig, M.] Lausanne Univ Hosp, Dept Psychiat, Ctr Psychiat Epidemiol & Psychopathol, Prilly, Switzerland.
   [Glaus, J.] NIMH, Genet Epidemiol Res Branch, Intramural Res Program, Bethesda, MD 20892 USA.
   [Marques-Vidal, P.; Waeber, G.; Vollenweider, P.] Lausanne Univ Hosp, Dept Internal Med, Lausanne, Switzerland.
C3 National Institutes of Health (NIH) - USA; NIH National Institute of
   Mental Health (NIMH); University of Lausanne; Centre Hospitalier
   Universitaire Vaudois (CHUV)
RP Lasserre, AM (corresponding author), Univ Lausanne, Dept Psychiat, Ctr Psychiat Epidemiol & Psychopathol, Site Cery, CH-1008 Lausanne, Prilly, Switzerland.
EM Aurelie.Lasserre@chuv.ch
RI Glaus, Jennifer/C-7887-2017; Preisig, Martin/H-3441-2016; Lasserre,
   Aurelie M/AEA-0456-2022; Marques-Vidal, Pedro/C-9449-2009; Vollenweider,
   Peter/Q-4603-2016
OI Lasserre, Aurelie M/0000-0003-3925-6663; Marques-Vidal,
   Pedro/0000-0002-4548-8500; Glaus, Jennifer/0000-0001-8883-9473;
   Castelao, Enrique/0000-0003-1966-3683; Vollenweider,
   Peter/0000-0002-0765-896X; Preisig, Martin/0000-0001-5689-4259;
   Vandeleur, Caroline/0000-0001-9092-6648; Waeber,
   Gerard/0000-0003-4193-788X; Strippoli, Marie-Pierre/0000-0003-3053-484X
FU GlaxoSmithKline; Faculty of Biology and Medicine of Lausanne; Swiss
   National Science Foundation [3200B0-105993, 3200B0-118308,
   33CSCO-122661, 33CS30-139468, 33CS30-148401, 323530_151479]; Swiss
   National Science Foundation (SNF) [323530_151479] Funding Source: Swiss
   National Science Foundation (SNF)
FX We express our gratitude to the Lausanne inhabitants who volunteered to
   participate in the CoLaus vertical bar PsyCoLaus study. We thank all the
   investigators of the study. The CoLaus vertical bar PsyCoLaus study was
   and is supported by research grants from GlaxoSmithKline, the Faculty of
   Biology and Medicine of Lausanne, and the Swiss National Science
   Foundation (grants 3200B0-105993, 3200B0-118308, 33CSCO-122661,
   33CS30-139468 and 33CS30-148401). Aurelie Lasserre is supported by a
   grant from the Swiss National Science Foundation (grant 323530_151479).
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TC 83
Z9 85
U1 0
U2 12
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 1359-4184
EI 1476-5578
J9 MOL PSYCHIATR
JI Mol. Psychiatr.
PD JUL
PY 2017
VL 22
IS 7
BP 1026
EP 1034
DI 10.1038/mp.2016.178
PG 9
WC Biochemistry & Molecular Biology; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Biochemistry & Molecular Biology; Neurosciences & Neurology; Psychiatry
GA EY3YK
UT WOS:000403911900011
PM 27725658
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Kim, JH
   Kim, HL
   Battushig, B
   Yoo, JY
AF Kim, Jin Hee
   Kim, Hyun Lye
   Battushig, Bolorchimeg
   Yoo, Jae Yong
TI Relationship between socio-demographics, body composition, emotional
   state, and social support on metabolic syndrome risk among adults in
   rural Mongolia
SO PLOS ONE
LA English
DT Article
ID NUTRITION EXAMINATION SURVEY; KOREAN NATIONAL-HEALTH; UNITED-STATES;
   OBESITY; PREVALENCE; ASSOCIATION; DEFINITION; PREVENTION; DEPRESSION;
   TRENDS
AB Background In Mongolia, where there is a large regional gap in the quality of healthcare services, metabolic syndrome (MetS) is steadily increasing. However, there are few studies on the risk level of MetS and affecting factors among adults living in rural Mongolia. This study aims to explore the relationship between socio-demographics, clinical characteristics, emotional state, and social support on the risk level of MetS prevalence among adults living in rural Mongolia. Methods In this cross-sectional study, 143 adults living in the soum area of Dondgovi aimag in Mongolia were recruited. Data collection was conducted from July 2 to 3, 2019. The self-reported questionnaires including socio-demographic, clinical characteristics and emotional status, anthropometric tests using the InBody, and blood sampling tests were conducted. The number of individual diagnostic criteria met was scored as a MetS risk score and classified into 6 groups, from the lowest score of 0 to the highest score of 5. The ordinal logistic regression analysis was used to identify the factors affecting the risk of MetS. Results The prevalence of MetS among adults living in rural Mongolia was 58.0%, and the mean MetS risk score was 2.70 +/- 1.34 points. In the ordinal logistic regression analysis, age, regular exercise of moderate intensity or higher, InBody score reflecting obesity or sarcopenia, and depression level were statistically significantly associated with the risk score for MetS. Conclusions Our study demonstrated that MetS risk levels among adults living in rural Mongolia with limited medical resources were strongly associated with demographic characteristics, body composition and emotional health condition, particularly depression.
C1 [Kim, Jin Hee; Kim, Hyun Lye; Yoo, Jae Yong] Chosun Univ, Dept Nursing, Coll Med, Gwangju, South Korea.
   [Battushig, Bolorchimeg] Mongolian Natl Univ, Sch Med, Dept Nursing, Ulaanbaatar, Mongolia.
C3 Chosun University; National University of Mongolia
RP Yoo, JY (corresponding author), Chosun Univ, Dept Nursing, Coll Med, Gwangju, South Korea.
EM jaeyongyoo@chosun.ac.kr
RI kim, jong-eun/B-3550-2017; KIM, SEON-OK/HGC-7012-2022
OI YOO, JAEYONG/0000-0002-1212-5121; Kim, Jinhee/0000-0002-8037-9174
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NR 54
TC 5
Z9 5
U1 0
U2 4
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PY 2021
VL 16
IS 9
AR e0254141
DI 10.1371/journal.pone.0254141
PG 18
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Science & Technology - Other Topics
GA XM7DR
UT WOS:000728983400034
PM 34570786
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Perez, I
   Hafidi, M
   Carvajal, K
   Baños, G
AF Perez, Israel
   Hafidi, Mohammed El
   Carvajal, Karla
   Banos, Guadalupe
TI Castration modifies aortic vasoreactivity and serum fatty acids in a
   sucrose-fed rat model of metabolic syndrome
SO HEART AND VESSELS
LA English
DT Article
DE Rat metabolic syndrome; Castration; Vascular reactivity; Free fatty
   acids
ID ENDOTHELIUM-DEPENDENT VASODILATION; SUGAR-INDUCED HYPERTENSION;
   SPRAGUE-DAWLEY RATS; BLOOD-PRESSURE; VASCULAR REACTIVITY; SEX-HORMONES;
   INSULIN-RESISTANCE; TESTOSTERONE; HYPERTRIGLYCERIDEMIA; ANDROGENS
AB Levels of testosterone and estradiol influence the incidence of cardiovascular diseases: generally, estrogens in females are protective before menopause; coronaropathies, hypertension, and dyslipidemias in normal men are more frequent at comparable ages. We investigated the modulation by castration of in vitro vasoreactivity, serum lipid content, and systolic blood pressure (SBP) in rats with sucrose-induced metabolic syndrome. The main characteristics of the rat model are: hypertriglyceridemia, moderately high blood pressure, intra-abdominal accumulation of adipose tissue, hyperinsulinemia, nephropathy, increased oxidative stress, and altered vasoreactivity. Male weanling rats received 30% sucrose solution for 16 weeks (metabolic syndrome; MS), controls (C) had plain water; both had commercial rodent chow. They were subdivided into five groups with two subgroups each: Group 1, intact C and MS rats, Groups 2-5, C and MS rats castrated for periods of 16, 12, 8, and 4 weeks. At the end of the study period, systolic blood pressure was measured, and blood and aortas were obtained for fatty acid determination and vasoreactivity assays, respectively. After 16 weeks' sucrose treatment MS aortas showed hypercontractility and decreased vasodilation. Palmitic and palmitoleic acids were increased in MS versus C. Arachidonic acid levels in MS were lower than in intact or castrated C. Long-term castration of 16 weeks normalized the levels of palmitic and oleic acids. With the shorter periods of castration, contractility increased and relaxation decreased in C and MS, but it was more significant in C. Regarding fatty acid composition, long-term castration increased polyunsaturated (arachidonic and eicosapentaenoic) fatty acids. The shorter periods did not modify the fatty acid profile in either C or MS. Metabolic syndrome altered SBP, aortic reactivity, and levels of fatty acids; castration of long duration normalized them in some cases.
C1 [Hafidi, Mohammed El; Carvajal, Karla; Banos, Guadalupe] Inst Nacl Cardiol Ignacio Chavez, Dept Biochem, Mexico City 14080, DF, Mexico.
   [Perez, Israel] Inst Nacl Cardiol Ignacio Chavez, Dept Pathol, Mexico City 14080, DF, Mexico.
C3 National Institute of Cardiology - Mexico; National Institute of
   Cardiology - Mexico
RP Baños, G (corresponding author), Inst Nacl Cardiol Ignacio Chavez, Dept Biochem, Juan Badiano 1,Tlalpan Col Secc 16, Mexico City 14080, DF, Mexico.
EM gbanos@yahoo.com
RI Pérez Torres, Israel/AAE-2579-2022
OI Perez-Torres, Israel/0000-0001-6510-2954; CARVAJAL,
   KARLA/0000-0002-5522-3266
FU National Council for Science and Technology (CONACyT) [3210-PM, 43229-M]
FX This work was partially supported by Grant Nos. 3210-PM and 43229-M from
   the National Council for Science and Technology (CONACyT) to G. B. and
   were the only sources of funding.
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NR 44
TC 12
Z9 13
U1 0
U2 5
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0910-8327
EI 1615-2573
J9 HEART VESSELS
JI Heart Vessels
PD MAR
PY 2009
VL 24
IS 2
BP 147
EP 155
DI 10.1007/s00380-008-1098-x
PG 9
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 428GM
UT WOS:000264836000013
PM 19337800
DA 2025-06-11
ER

PT J
AU Khodavirdipour, A
   Haddadi, F
   Keshavarzi, S
AF Khodavirdipour, Amir
   Haddadi, Fatemeh
   Keshavarzi, Shiva
TI Chromium Supplementation; Negotiation with Diabetes Mellitus,
   Hyperlipidemia and Depression
SO JOURNAL OF DIABETES AND METABOLIC DISORDERS
LA English
DT Review
DE Chromium; Cancer; Cardiovascular disease; Depression; Diabetes Mellitus;
   Hyperlipidaemia; Trace Elements
ID ACTIVATED PROTEIN-KINASE; HIGH-DENSITY-LIPOPROTEIN; GLUCOSE-TOLERANCE;
   SERUM-LIPIDS; GLYCEMIC CONTROL; PICOLINATE SUPPLEMENTATION;
   MOLECULAR-MECHANISMS; INSULIN SENSITIVITY; INORGANIC CHROMIUM;
   BODY-COMPOSITION
AB Chromium (Cr) is an essential trace element which found naturally in a daily diet and available in the form of supplementary tablets to boost disorders like diabetes mellitus (DM) and functions like lipid metabolism and beneficial on depression too. Diabetes is one of the most prevalent endocrine diseases or in other words, the most severe metabolic syndrome (MS), which associated with high production of free-radicals which is out of bodies detoxifying machine capacity or high oxidative stress (HOS), vasculitis and elevated lipid profile. many research papers and clinical trials published about the significance of chromium on biological activities, pre and post clinical. For this review research articles, clinical trials, from 1(st) Jan'10 to 31(st) Dec'18 and refer literature for the biochemical, pharmacological and biological activity of Chromium. Primarily articles gathered from the above search engines. Then precisely according to our aim and goal and regarding designed objectives dismisses similar articles and finally came to 84 articles for the above said period. This review trying to cover the entire picture from what chromium is to the recent updates on their greater role in increasing insulin sensitivity of cells and enhancing lipid metabolism and even recent findings suggest its positive effects including prevention and ameliorating properties on depression. The biological activities, pharmacological features, clinical implications including efficacy and role of chromium compounds on the glycaemic index will be discussed. The outcome of this review is to bring the pros and cons of chromium supplementation along with is safety and toxicity concern beside molecular pathways, biochemistry and clinical trials, all in one comprehensive review.
C1 [Khodavirdipour, Amir] St Johns Hosp, Div Human Genet, Dept Anat, Bangalore, Karnataka, India.
   [Khodavirdipour, Amir] Univ Tabriz, Dept Biol, Fac Nat Sci, Tabriz 9861335856, Iran.
   [Haddadi, Fatemeh; Keshavarzi, Shiva] Univ Zabol, Dept Biol, Fac Sci, Zabol, Iran.
C3 University of Tabriz
RP Haddadi, F (corresponding author), Univ Zabol, Dept Biol, Fac Sci, Zabol, Iran.
EM haddadifatemeh@yahoo.com
RI Khodavirdipour, Amir/AAX-1815-2021
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NR 86
TC 29
Z9 30
U1 3
U2 36
PU SPRINGER INT PUBL AG
PI CHAM
PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND
EI 2251-6581
J9 J DIABETES METAB DIS
JI J. Diabetes Metab. Disord.
PD JUN
PY 2020
VL 19
IS 1
BP 585
EP 595
DI 10.1007/s40200-020-00501-8
PG 11
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA NR3GL
UT WOS:000571450700066
PM 32550211
OA Green Published
DA 2025-06-11
ER

PT J
AU Sato, A
   Yumita, Y
   Kagami, K
   Ishinoda, Y
   Kimura, T
   Osaki, A
   Toya, T
   Namba, T
   Endo, S
   Ido, Y
   Nagatomo, Y
   Satoh, Y
   Adachi, T
AF Sato, Atsushi
   Yumita, Yusuke
   Kagami, Kazuki
   Ishinoda, Yuki
   Kimura, Toyokazu
   Osaki, Ayumu
   Toya, Takumi
   Namba, Takayuki
   Endo, Shogo
   Ido, Yasuo
   Nagatomo, Yuji
   Satoh, Yasushi
   Adachi, Takeshi
TI Endothelial Extracellular Signal-Regulated Kinase/Thromboxane
   A2/Prostanoid Receptor Pathway Aggravates Endothelial Dysfunction and
   Insulin Resistance in a Mouse Model of Metabolic Syndrome
SO JOURNAL OF THE AMERICAN HEART ASSOCIATION
LA English
DT Article
DE endothelium; extracellular signal-regulated kinase 2; hypertension;
   insulin resistance; metabolic syndrome
ID NITRIC-OXIDE SYNTHASE; THROMBOXANE A(2); ANGIOTENSIN-II;
   CARDIOVASCULAR-DISEASE; S-GLUTATHIOLATION; OXIDATIVE STRESS;
   BLOOD-PRESSURE; CONTRIBUTES; ANTAGONIST; ACTIVATION
AB BackgroundMetabolic syndrome is characterized by insulin resistance, which impairs intracellular signaling pathways and endothelial NO bioactivity, leading to cardiovascular complications. Extracellular signal-regulated kinase (ERK) is a major component of insulin signaling cascades that can be activated by many vasoactive peptides, hormones, and cytokines that are elevated in metabolic syndrome. The aim of this study was to clarify the role of endothelial ERK2 in vivo on NO bioactivity and insulin resistance in a mouse model of metabolic syndrome. Methods and ResultsControl and endothelial-specific ERK2 knockout mice were fed a high-fat/high-sucrose diet (HFHSD) for 24 weeks. Systolic blood pressure, endothelial function, and glucose metabolism were investigated. Systolic blood pressure was lowered with increased NO products and decreased thromboxane A2/prostanoid (TP) products in HFHSD-fed ERK2 knockout mice, and N omega-nitro-l-arginine methyl ester (L-NAME) increased it to the levels observed in HFHSD-fed controls. Acetylcholine-induced relaxation of aortic rings was increased, and aortic superoxide level was lowered in HFHSD-fed ERK2 knockout mice. S18886, an antagonist of the TP receptor, improved endothelial function and decreased superoxide level only in the rings from HFHSD-fed controls. Glucose intolerance and the impaired insulin sensitivity were blunted in HFHSD-fed ERK2 knockout mice without changes in body weight. In vivo, S18886 improved endothelial dysfunction, systolic blood pressure, fasting serum glucose and insulin levels, and suppressed nonalcoholic fatty liver disease scores only in HFHSD-fed controls. ConclusionsEndothelial ERK2 increased superoxide level and decreased NO bioactivity, resulting in the deterioration of endothelial function, insulin resistance, and steatohepatitis, which were improved by a TP receptor antagonist, in a mouse model of metabolic syndrome.
C1 [Sato, Atsushi; Yumita, Yusuke; Kagami, Kazuki; Ishinoda, Yuki; Kimura, Toyokazu; Osaki, Ayumu; Toya, Takumi; Namba, Takayuki; Ido, Yasuo; Nagatomo, Yuji; Adachi, Takeshi] Natl Def Med Coll, Dept Cardiol, Tokorozawa, Japan.
   [Satoh, Yasushi] Natl Def Med Coll, Dept Biochem, Tokorozawa, Japan.
   [Endo, Shogo] Tokyo Metropolitan Inst Gerontol, Dept Aging Neurosci, Tokyo, Japan.
   [Adachi, Takeshi] Natl Def Med Coll, Dept Internal Med 1, 3-2 Namiki, Tokorozawa, Saitama 3598513, Japan.
C3 National Defense Medical College - Japan; National Defense Medical
   College - Japan; Tokyo Metropolitan Institute of Gerontology; National
   Defense Medical College - Japan
RP Adachi, T (corresponding author), Natl Def Med Coll, Dept Internal Med 1, 3-2 Namiki, Tokorozawa, Saitama 3598513, Japan.
EM tadachibu@gmail.com
RI Nagatomo, Yuji/AAQ-1590-2020; Yumita, Yusuke/GXH-7782-2022; Endo,
   Shogo/LKJ-5968-2024
OI KAGAMI, KAZUKI/0000-0002-1743-4409; Toya, Takumi/0000-0002-4681-2798;
   sato, atsushi/0000-0002-2138-3173; Nagatomo, Yuji/0000-0002-3430-4614;
   Yumita, Yusuke/0000-0002-0186-5968; Endo, Shogo/0000-0002-3948-8723;
   Ishinoda, Yuki/0000-0002-7477-8638
FU Ministry of Defense;  [18H02815];  [18K08120];  [17K09565];  [17K09596];
   Grants-in-Aid for Scientific Research [21K19752] Funding Source: KAKEN
FX This work was supported by a Grant-in-Aid for Scientific Research (B)
   (18H02815) and Scientific Research (C) (numbers 18K08120, 17K09565, and
   17K09596) and a Grant-in-Aid from the Ministry of Defense.
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NR 53
TC 6
Z9 6
U1 0
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
EI 2047-9980
J9 J AM HEART ASSOC
JI J. Am. Heart Assoc.
PD DEC 6
PY 2022
VL 11
IS 23
DI 10.1161/JAHA.122.027538
PG 16
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 6T7OX
UT WOS:000893866000025
PM 36382966
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Leguina-Ruzzi, A
   Pereira, J
   Pereira-Flores, K
   Valderas, JP
   Mezzano, D
   Velarde, V
   Sáez, CG
AF Leguina-Ruzzi, Alberto
   Pereira, Jaime
   Pereira-Flores, Karla
   Valderas, Juan P.
   Mezzano, Diego
   Velarde, Victoria
   Saez, Claudia G.
TI Increased RhoA/Rho-Kinase Activity and Markers of Endothelial
   Dysfunction in Young Adult Subjects with Metabolic Syndrome
SO METABOLIC SYNDROME AND RELATED DISORDERS
LA English
DT Article
ID INSULIN-RESISTANCE; SERUM CREATININE; LINKING OBESITY; RISK-FACTOR;
   ACID; ASSOCIATION; PLASMA; ACTIVATION; ADIPOCYTE; OXIDATION
AB Background: Metabolic syndrome, a chronic condition associated with higher risk of cardiovascular diseases, is increasingly prevalent in young adults. Dyslipidemia, proinflammatory cytokines, endothelial dysfunction signs, and RhoA/Rho-kinase (ROCK) activation are considered risk factors of cardiovascular diseases. The occurrence of these factors in young patients with metabolic syndrome but without type 2 diabetes or hypertension has not been fully studied. The objective of this study was to evaluate young subjects with enlarged waist circumference and dyslipidemia but without type 2 diabetes or hypertension,for markers associated with a higher risk of cardiovascular diseases. Methods: Thirty-two male patients aged 311.3 years diagnosed with metabolic syndrome according to the National Cholesterol Education Program Adult Treatment Panel III guide for enlarged waist circumference, elevated triglycerides, and low HDL levels, but with blood pressure and fasting glucose within normal ranges, were evaluated for RhoA/ROCK activity in leukocytes, serum fatty acid methyl esters profile, proinflammatory cytokines, and oxidative stress markers in addition to thrombin generation and biochemical analysis. Age- and gender-matched healthy subjects were equivalently evaluated. Results: Patients showed higher RhoA/ROCK activity, elevated levels of interleukin-6, soluble CD40L, monocyte chemoattractant protein, and high-sensitivity C-reactive protein (P<0.001) as well as parameters of endogenous thrombin generation potential (P<0.05) compared with healthy subjects. Increased thiobarbituric acid reactive substances, advanced oxidation protein product, and insulin levels and low nitric oxide biodisponibility (P<0.001) were also found in patients as compared with controls. Palmitic acid was one of the saturated fatty acids found to be significantly elevated in patients compared with control subjects (P=0.0087). Conclusions: Increased markers of cardiovascular risk are already present in young adults with metabolic syndrome but without type 2 diabetes or hypertension.
C1 [Leguina-Ruzzi, Alberto; Pereira, Jaime; Pereira-Flores, Karla; Mezzano, Diego; Saez, Claudia G.] Pontificia Univ Catolica Chile, Sch Med, Dept Hematol & Oncol, Santiago 8330334, Chile.
   [Velarde, Victoria] Pontificia Univ Catolica Chile, Fac Ciencias Biol, Dept Physiol, Santiago 8330334, Chile.
   [Valderas, Juan P.] Univ Antofagasta, Fac Med Odontol, Dept Ciencias Med, Antofagasta, Chile.
C3 Pontificia Universidad Catolica de Chile; Pontificia Universidad
   Catolica de Chile; Universidad de Antofagasta
RP Sáez, CG (corresponding author), Pontificia Univ Catolica Chile, Sch Med, Dept Hematol & Oncol, Portugal 61,Second Floor, Santiago 8330334, Chile.
EM cgsaez@med.puc.cl
RI ; Leguina-Ruzzi, Alberto/K-5805-2017; Saez Steeger,
   Claudia/HCI-4472-2022
OI Velarde, Victoria/0000-0002-4465-831X; Leguina-Ruzzi,
   Alberto/0000-0002-4761-3491; , Pereira-Flores K/0009-0000-1357-5231;
   Saez Steeger, Claudia/0000-0001-7183-1491
FU Fondo Nacional de Desarrollo Cientifico y Tecnologico (FONDECYT)
   [1141051]; Puente [20/2013]; Direccion de Investigacion y Doctorado
   (DIDEMUC); Faculty of Medicine: Doctoral Thesis Support; Comision
   Nacional de Investigacio n Cientifica y Tecnologica (CONICYT)
FX This work was supported by Fondo Nacional de Desarrollo Cientifico y
   Tecnologico (FONDECYT) grant no. 1141051 (J. Pereira), Puente 20/2013
   (V. Velarde), a Comision Nacional de Investigacio n Cientifica y
   Tecnologica (CONICYT) doctoral grant (A. Leguina-Ruzzi), and the
   Direccion de Investigacion y Doctorado (DIDEMUC), Faculty of Medicine:
   Doctoral Thesis Support (A. Leguina-Ruzzi, mentored by C.G. Saez)
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NR 50
TC 21
Z9 22
U1 0
U2 9
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-4196
EI 1557-8518
J9 METAB SYNDR RELAT D
JI Metab. Syndr. Relat. Disord.
PD NOV 1
PY 2015
VL 13
IS 9
BP 373
EP 380
DI 10.1089/met.2015.0061
PG 8
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA CU9TP
UT WOS:000363888500002
PM 26512756
DA 2025-06-11
ER

PT J
AU Robertson, K
   Griffith, TA
   Helman, TJ
   Hatton-Jones, K
   Naghipour, S
   Robertson, DA
   Peart, JN
   Headrick, JP
   Du Toit, EF
AF Robertson, Kai
   Griffith, Tia A.
   Helman, Tessa J.
   Hatton-Jones, Kyle
   Naghipour, Saba
   Robertson, Dylan A.
   Peart, Jason N.
   Headrick, John P.
   Du Toit, Eugene F.
TI Early life stress exacerbates the obesogenic and anxiogenic effects of a
   Western diet without worsening cardiac ischaemic tolerance in male mice
SO JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE
LA English
DT Article
DE Anxiogenesis; early life stress; Western diet; cardiometabolic risk;
   dietary obesity; myocardial ischaemia-reperfusion
ID NATIONAL COMORBIDITY SURVEY; LEFT-VENTRICULAR MASS; MATERNAL SEPARATION;
   INSULIN-RESISTANCE; CHILDHOOD ABUSE; DEVELOPMENTAL ORIGINS;
   MYOCARDIAL-ISCHEMIA; HEART-DISEASE; RODENT MODEL; FEMALE RATS
AB Early life stress (ELS) and a Western diet (WD) promote mood and cardiovascular disorders, however, how these risks interact in disease pathogenesis is unclear. We assessed effects of ELS with or without a subsequent WD on behaviour, cardiometabolic risk factors, and cardiac function/ischaemic tolerance in male mice. Fifty-six new-born male C57BL/6J mice were randomly allocated to a control group (CON) undisturbed before weaning, or to maternal separation (3h/day) and early (postnatal day 17) weaning (MSEW). Mice consumed standard rodent chow (CON, n = 14; MSEW, n = 15) or WD chow (WD, n = 19; MSEW + WD, n = 19) from week 8 to 24. Fasted blood was sampled and open field test and elevated plus maze (EPM) tests undertaken at 7, 15, and 23 weeks of age, with hearts excised at 24 weeks for Langendorff perfusion (evaluating pre- and post-ischaemic function). MSEW alone transiently increased open field activity at 7 weeks; body weight and serum triglycerides at 4 and 7 weeks, respectively; and final blood glucose levels and insulin resistance at 23 weeks. WD increased insulin resistance and body weight gain, the latter potentiated by MSEW. MSEW + WD was anxiogenic, reducing EPM open arm activity vs. WD alone. Although MSEW had modest metabolic effects and did not influence cardiac function or ischaemic tolerance in lean mice, it exacerbated weight gain and anxiogenesis, and improved ischaemic tolerance in WD fed animals. MSEW-induced increases in body weight (obesity) in WD fed animals in the absence of changes in insulin resistance may have protected the hearts of these mice.
C1 [Robertson, Kai; Griffith, Tia A.; Helman, Tessa J.; Hatton-Jones, Kyle; Naghipour, Saba; Robertson, Dylan A.; Peart, Jason N.; Headrick, John P.; Du Toit, Eugene F.] Griffith Univ Gold Coast, Sch Pharm & Med Sci, Southport, Qld, Australia.
C3 Griffith University; Griffith University - Gold Coast Campus
RP Du Toit, EF (corresponding author), Griffith Univ Gold Coast, Sch Pharm & Med Sci, Southport, Qld, Australia.
EM j.dutoit@griffith.edu.au
RI Helman, Tessa/IWM-3236-2023; Naghipour, Saba/NKO-8765-2025
OI Hatton-Jones, Kyle/0000-0003-3988-0829; Naghipour,
   Saba/0000-0001-6624-5674; Robertson, Kai/0009-0005-5477-951X; Helman,
   Tessa/0000-0001-8788-3683
FU Griffith University
FX The work was supported by a seed grant and HDR student funds from
   Griffith University.
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NR 98
TC 1
Z9 1
U1 2
U2 2
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 2040-1744
EI 2040-1752
J9 J DEV ORIG HLTH DIS
JI J. Dev. Orig. Health Dis.
PD SEP 18
PY 2024
VL 15
AR e14
DI 10.1017/S2040174424000205
PG 13
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA G1X7M
UT WOS:001314645400001
PM 39291337
DA 2025-06-11
ER

PT J
AU Flory, JD
   Bierer, LM
   Yehuda, R
AF Flory, Janine D.
   Bierer, Linda M.
   Yehuda, Rachel
TI Maternal exposure to the holocaust and health complaints in offspring
SO DISEASE MARKERS
LA English
DT Article
ID POSTTRAUMATIC-STRESS-DISORDER; CORONARY-HEART-DISEASE; DEVELOPMENTAL
   ORIGINS; BLOOD-PRESSURE; METABOLIC SYNDROME; LOW CORTISOL; ADULT LIFE;
   RISK; PTSD; MORTALITY
AB Although the link between chronic stress and the development of cardiovascular and metabolic diseases of adulthood has been known for some time, there is growing recognition that early environmental influences may result in developmental programming via epigenetic mechanisms, thereby affecting the developmental trajectory of disease progression. Previous studies support the idea that offspring of Holocaust survivors may have been subjected to early developmental programming. We evaluated the relationship between parental exposure to the Holocaust and self-reported health ratings and disorders made by their adult offspring (i.e., second generation Holocaust survivors). A total of 137 subjects were evaluated. Regression analyses demonstrated that maternal but not paternal exposure to the Holocaust was related to poorer subjective impressions of emotional and physical health. This relationship was diminished when the offspring's own level of trait anxiety was considered. Offspring with maternal, but not paternal, Holocaust exposure also reported greater use of psychotropic and other medications, including medications for the treatment of hypertension and lipid disorders. The mechanism linking these health outcomes and maternal exposure deserves further investigation, including the possibility that fetal or early developmental programming is involved.
C1 [Flory, Janine D.] CUNY, Queens Coll, Dept Psychol, Flushing, NY 11367 USA.
   [Flory, Janine D.] CUNY, Grad Ctr, Flushing, NY 11367 USA.
   [Flory, Janine D.; Bierer, Linda M.; Yehuda, Rachel] Bronx Vet Affairs Med Ctr, Dept Psychiat, Bronx, NY USA.
   [Yehuda, Rachel] Mt Sinai Sch Med, Dept Psychiat, New York, NY USA.
C3 City University of New York (CUNY) System; Queens College NY (CUNY);
   City University of New York (CUNY) System; US Department of Veterans
   Affairs; Veterans Health Administration (VHA); James J. Peters VA
   Medical Center; Icahn School of Medicine at Mount Sinai
RP Flory, JD (corresponding author), CUNY, Queens Coll, Dept Psychol, NSB E-318,65-30 Kissena Blvd, Flushing, NY 11367 USA.
EM janine.flory@qc.cuny.edu
FU NIMH [R01-MH-64675-01]
FX This work was supported by NIMH grant R01-MH-64675-01 ("Biology of Risk
   and PTSD in Holocaust Survivor Offspring") to Rachel Yehuda.
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NR 47
TC 50
Z9 58
U1 1
U2 20
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 0278-0240
EI 1875-8630
J9 DIS MARKERS
JI Dis. Markers
PY 2011
VL 30
IS 2-3
BP 133
EP 139
DI 10.1155/2011/250470
PG 7
WC Biotechnology & Applied Microbiology; Genetics & Heredity; Medicine,
   Research & Experimental; Pathology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Biotechnology & Applied Microbiology; Genetics & Heredity; Research &
   Experimental Medicine; Pathology
GA 773YN
UT WOS:000291348100008
PM 21508517
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Fathi, M
   Alavinejad, P
   Haidari, Z
   Amani, R
AF Fathi, Mojdeh
   Alavinejad, Pezhman
   Haidari, Zahra
   Amani, Reza
TI The effects of zinc supplementation on metabolic profile and oxidative
   stress in overweight/obese patients with non-alcoholic fatty liver
   disease: A randomized, double-blind, placebo-controlled trial
SO JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
LA English
DT Article
DE Zinc supplementation; Calorie- restriction diet; Non-alcoholic fatty
   liver; Insulin resistance; Oxidative stress
ID INSULIN-RESISTANCE; NONDIABETIC PATIENTS; GLYCEMIC CONTROL; LIPID
   PROFILES; OBESE; DEFICIENCY; STEATOHEPATITIS; PATHOGENESIS; HOMEOSTASIS;
   ADAPTATION
AB Background: Evidence indicates the positive effects of zinc on insulin resistance and oxidative stress in metabolic syndrome or diabetes. Non-alcoholic fatty liver disease (NAFLD) is the main hepatic manifestation of insulin resistance and metabolic syndrome. The present study is the first clinical trial that evaluated the effects of zinc supplementation on metabolic and oxidative stress status in overweight/obese patients with NAFLD undergoing calorie- restriction diet. Methods: Fifty six overweight/obese patients with confirmed mild to moderate NAFLD using ultrasonography were randomly allocated to receive 30 mg elemental zinc supplement (n = 29) or placebo (n = 27) along with weight loss diet for 12 weeks. Serum levels of zinc, homeostasis model of assessment-estimated insulin resistance (HOMA-IR), lipid profile, serum superoxide dismutasl (SOD1) and malondialdhyde (MDA) levels were assessed.
   Results: Serum levels of insulin, SOD1, MDA and HOMA-IR were improved in the treatment group (p < 0.05). Within group comparison showed significant reduction in serum FBS, HbA(1C), TC, LDL-c and TG in the treatment group. Conclusion: Zinc supplementation for three months improved insulin resistance and oxidative stress status in overweight/obese NAFLD patients with no beneficial effects on lipid profiles over weight loss diet.
C1 [Fathi, Mojdeh; Amani, Reza] Isfahan Univ Med Sci, Food Secur Res Ctr, Sch Nutr & Food Sci, Dept Clin Nutr, Esfahan 8173948763, Iran.
   [Alavinejad, Pezhman] Ahvaz Jundishapur Univ Med Sci, Ahvaz Imam Hosp, Alimentary Tract Res Ctr, Ahvaz, Iran.
   [Haidari, Zahra] Isfahan Univ Med Sci, Sch Hlth, Dept Biostat & Epidemiol, Esfahan, Iran.
C3 Isfahan University of Medical Sciences; Ahvaz Jundishapur University of
   Medical Sciences (AJUMS); Isfahan University of Medical Sciences
RP Amani, R (corresponding author), Isfahan Univ Med Sci, Food Secur Res Ctr, Sch Nutr & Food Sci, Dept Clin Nutr, Esfahan 8173948763, Iran.
EM r_amani@mail.mui.ac.ir
RI Alavinejad, Pezhman/AAD-2742-2020; Amani, Reza/U-7483-2017
FU Iran National Science Foundation (INSF) [97014520]
FX The study was funded by a research grant from Iran National Science
   Foundation (INSF) (Grant Number: 97014520).
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NR 58
TC 27
Z9 27
U1 1
U2 7
PU ELSEVIER GMBH
PI MUNICH
PA HACKERBRUCKE 6, 80335 MUNICH, GERMANY
SN 0946-672X
EI 1878-3252
J9 J TRACE ELEM MED BIO
JI J. Trace Elem. Med. Biol.
PD DEC
PY 2020
VL 62
AR 126635
DI 10.1016/j.jtemb.2020.126635
PG 6
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA OM4WV
UT WOS:000586028000066
PM 32932174
DA 2025-06-11
ER

PT J
AU Syrovatka, P
   Kraml, P
   Potockova, J
   Fialova, L
   Vejrazka, M
   Crkovska, J
   Andel, M
AF Syrovatka, Petr
   Kraml, Pavel
   Potockova, Jana
   Fialova, Lenka
   Vejrazka, Martin
   Crkovska, Jirina
   Andel, Michal
TI Relationship between Increased Body Iron Stores, Oxidative Stress and
   Insulin Resistance in Healthy Men
SO ANNALS OF NUTRITION AND METABOLISM
LA English
DT Article
DE Iron; Ferritin; Oxidative stress; Insulin resistance; Atherosclerosis
ID EASTERN FINNISH MEN; MYOCARDIAL-INFARCTION; SERUM FERRITIN; CAROTID
   ATHEROSCLEROSIS; METABOLIC SYNDROME; OVERLOAD AUGMENTS; RISK; DISEASE;
   BLOOD; COMMUNITIES
AB Aim: The aim of our cross-sectional study was to assess the relationships between body iron stores, oxidative stress, impaired insulin sensitivity and carotid atherosclerosis in a cohort of healthy men in primary prevention of cardiovascular disease. Methods: We examined 151 volunteers, aged 35 60 years. Anthropometric parameters, markers of metabolic syndrome, insulin resistance, inflammatory markers, parameters of oxidative stress and intima-media thickness of common carotid artery were measured. Results: Ferritin correlated positively with waist circumference, body mass index, impaired insulin sensitivity, plasma triglycerides and inversely with high-density lipoprotein cholesterol. We observed positive correlations between ferritin, oxidized low-density lipoprotein and advanced oxidation protein products after adjustment for age, waist circumference, body mass index and measured inflammatory markers (high-sensitivity C-reactive protein, fibrinogen, interleukin-6 and tumor necrosis factor-alpha). There were no significant associations between ferritin and intima-media thickness or markers of endothelial dysfunction. In a stepwise multiple regression analysis, triglycerides, waist circumference and elevated transaminases were independent determinants of the serum ferritin level. Conclusion: Our results provide evidence for a relationship between plasma ferritin and oxidative modification of lipids as well as proteins in vivo. Higher body iron stores may contribute to impaired insulin sensitivity through increased oxidative stress in a cohort of healthy men. Copyright (C) 2009 S. Karger AG, Basel
C1 [Syrovatka, Petr] Charles Univ Prague, Inst Clin & Expt Med, Dept Cardiol, CZ-14021 Prague 4, Czech Republic.
   [Syrovatka, Petr; Kraml, Pavel; Potockova, Jana; Andel, Michal] Charles Univ Prague, Fac Med 3, Dept Internal Med 2, CZ-14021 Prague 4, Czech Republic.
   [Fialova, Lenka; Vejrazka, Martin; Crkovska, Jirina] Charles Univ Prague, Fac Med 1, Dept Med Chem 1, CZ-14021 Prague 4, Czech Republic.
C3 Institute for Clinical & Experimental Medicine (IKEM); Charles
   University Prague; Charles University Prague; Charles University Prague
RP Syrovatka, P (corresponding author), Charles Univ Prague, Inst Clin & Expt Med, Dept Cardiol, Videnska 1958-9, CZ-14021 Prague 4, Czech Republic.
EM petr.syrovatka@seznam.cz
RI Andel, Michal/E-4305-2012; Vejrazka, Martin/D-2327-2017; Crkovska,
   Jirina/J-2683-2017; Fialova, Lenka/G-9419-2017
OI Vejrazka, Martin/0000-0001-5127-8975; Crkovska,
   Jirina/0000-0002-5456-5117; Fialova, Lenka/0000-0001-8137-7771
FU Ministry of Education, Czech Republic [MSM0021620814]
FX This study was supported by the research program of the Ministry of
   Education, Czech Republic, No. MSM0021620814.
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NR 32
TC 39
Z9 40
U1 0
U2 10
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0250-6807
EI 1421-9697
J9 ANN NUTR METAB
JI Ann. Nutr. Metab.
PY 2009
VL 54
IS 4
BP 268
EP 274
DI 10.1159/000229507
PG 7
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 511EZ
UT WOS:000271148000003
PM 19641304
DA 2025-06-11
ER

PT J
AU Ebrahimi, F
   Urwyler, SA
   Betz, MJ
   Christ, ER
   Schuetz, P
   Mueller, B
   Donath, MY
   Christ-Crain, M
AF Ebrahimi, Fahim
   Urwyler, Sandrine Andrea
   Betz, Matthias Johannes
   Christ, Emanuel Remigius
   Schuetz, Philipp
   Mueller, Beat
   Donath, Marc Yves
   Christ-Crain, Mirjam
TI Effects of interleukin-1 antagonism and corticosteroids on fibroblast
   growth factor-21 in patients with metabolic syndrome
SO SCIENTIFIC REPORTS
LA English
DT Article
ID BETA-KLOTHO EXPRESSION; PLASMA-CONCENTRATIONS; FGF21 LEVELS; ACTIVATION;
   INFLAMMATION; PROTEIN; OBESITY; ATHEROSCLEROSIS; MARKERS; STRESS
AB Fibroblast growth factor-21 (FGF21) is elevated in patients with the metabolic syndrome. Although the exact underlying mechanisms remain ill-defined, chronic low-grade inflammation with increased Interleukin-(IL)-1 beta expression may be responsible. The aim of this study was to investigate effects of two different anti-inflammatory treatments (IL-1 antagonism or high-dose corticosteroids) on FGF21 in patients with the metabolic syndrome. This is a secondary analysis of two interventional studies in patients with obesity and features of the metabolic syndrome. Trial A was an interventional trial (n=73) investigating short-term effects of the IL-1 antagonist anakinra and of dexamethasone. Trial B was a randomized, placebo-controlled, double-blinded trial (n=67) investigating longer-term effects of IL-1 antagonism. In total, 140 patients were included in both trials. Median age was 55 years (IQR 44-66), 26% were female and median BMI was 37 kg/m(2) (IQR 34-39). Almost half of the patients were diabetic (45%) and had increased c-reactive protein levels of 3.4 mg/L. FGF21 levels correlated with fasting glucose levels, HOMA-index, C-peptide levels, HbA1c and BMI. Short-term treatment with anakinra led to a reduction of FGF21 levels by - 200 pg/mL (95%CI - 334 to - 66; p=0.004). No effect was detectable after longer-term treatment (between-group difference: - 8.8 pg/mL (95%CI - 130.9 to 113.3; p=0.89). Acute treatment with dexamethasone was associated with reductions of FGF21 by -175 pg/mL (95%CI - 236 to - 113; p<0.001). Anti-inflammatory treatment with both, IL-1 antagonism and corticosteroids reduced FGF21 levels at short-term in individuals with the metabolic syndrome.Trial registration: ClinicalTrials.gov Identifiers NCT02672592 and NCT00757276.
C1 [Ebrahimi, Fahim; Urwyler, Sandrine Andrea; Betz, Matthias Johannes; Christ, Emanuel Remigius; Donath, Marc Yves; Christ-Crain, Mirjam] Univ Hosp Basel, Div Endocrinol Diabet & Metab, Basel, Switzerland.
   [Ebrahimi, Fahim; Urwyler, Sandrine Andrea; Betz, Matthias Johannes; Christ, Emanuel Remigius; Schuetz, Philipp; Mueller, Beat; Donath, Marc Yves; Christ-Crain, Mirjam] Univ Hosp Basel, Dept Clin Res, Basel, Switzerland.
   [Schuetz, Philipp; Mueller, Beat] Kantonsspital Aarau, Univ Dept Med, Div Endocrinol Diabet & Metab, Aarau, Switzerland.
   [Ebrahimi, Fahim] Univ Hosp Basel, Univ Ctr Gastrointestinal & Liver Dis, Basel, Switzerland.
C3 University of Basel; University of Basel; Kantonsspital Aarau AG (KSA);
   University of Basel
RP Ebrahimi, F (corresponding author), Univ Hosp Basel, Div Endocrinol Diabet & Metab, Basel, Switzerland.; Ebrahimi, F (corresponding author), Univ Hosp Basel, Dept Clin Res, Basel, Switzerland.; Ebrahimi, F (corresponding author), Univ Hosp Basel, Univ Ctr Gastrointestinal & Liver Dis, Basel, Switzerland.
EM f.ebrahimi@outlook.com
RI Ebrahimi, Fahim/JQI-5819-2023; Schuetz, Philipp/C-8475-2013
OI Christ-Crain, Mirjam/0000-0002-6336-0965; Urwyler, Sandrine
   Andrea/0000-0003-4056-2262; Ebrahimi, Fahim/0000-0001-5862-966X; Betz,
   Matthias Johannes/0000-0002-6946-1871; Schuetz,
   Philipp/0000-0001-6400-4949
FU Swiss National Science Foundation (SNSF, National Research Program) [NRP
   74, 407440_167376]; Swiss National Foundation [PP00P312346];
   "Wissenschaftspool 2014" of the University Hospital of Basel; University
   of Basel (Nachwuchsfoerderung 2015); "Young Talents in Clinical
   Research" program by the Bangerter Foundation; Swiss Academy of Medical
   Sciences (SAMS); "Wissenschaftspool" of the University Hospital of
   Basel; University of Basel (Nachwuchsfoerderung 2017); Swiss National
   Science Foundation (SNF) [407440_167376] Funding Source: Swiss National
   Science Foundation (SNF)
FX This study was supported in part by the Swiss National Science
   Foundation (SNSF, National Research Program (NRP 74), 407440_167376).
   This work was supported by a grant of the Swiss National Foundation (Nr
   PP00P312346) to MCC, a grant of the "Wissenschaftspool 2014" of the
   University Hospital of Basel to SU and a grant of the University of
   Basel (Nachwuchsfoerderung 2015) to SU. FE was supported by the "Young
   Talents in Clinical Research" program by the Bangerter Foundation and
   the Swiss Academy of Medical Sciences (SAMS). FE also received a grant
   of the "Wissenschaftspool" of the University Hospital of Basel and a
   grant of the University of Basel (Nachwuchsfoerderung 2017). The funding
   sources had no role in study design, data collection, data analysis,
   data interpretation, or writing of the report. FE, SAU and MCC had full
   access to all the data in the study and had final responsibility for the
   decision to submit for publication.
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NR 50
TC 2
Z9 2
U1 0
U2 1
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD APR 12
PY 2021
VL 11
IS 1
AR 7911
DI 10.1038/s41598-021-87207-w
PG 8
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA RN6AP
UT WOS:000640434400044
PM 33846498
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Hattori, T
   Murase, T
   Takatsu, M
   Nagasawa, K
   Matsuura, N
   Watanabe, S
   Murohara, T
   Nagata, K
AF Hattori, Takuya
   Murase, Tamayo
   Takatsu, Miwa
   Nagasawa, Kai
   Matsuura, Natsumi
   Watanabe, Shogo
   Murohara, Toyoaki
   Nagata, Kohzo
TI Dietary Salt Restriction Improves Cardiac and Adipose Tissue Pathology
   Independently of Obesity in a Rat Model of Metabolic Syndrome
SO JOURNAL OF THE AMERICAN HEART ASSOCIATION
LA English
DT Article
DE diet; hypertension; obesity; remodeling; sodium
ID DIASTOLIC DYSFUNCTION; HEART-FAILURE; INSULIN-RESISTANCE;
   BLOOD-PRESSURE; ANIMAL-MODEL; DAHLS.Z-LEPR(FA)/LEPR(FA) RATS;
   MINERALOCORTICOID RECEPTORS; WISTAR RATS; SODIUM; PHOSPHORYLATION
AB Background-Metabolic syndrome (MetS) enhances salt sensitivity of blood pressure and is an important risk factor for cardiovascular disease. The effects of dietary salt restriction on cardiac pathology associated with metabolic syndrome remain unclear.
   Methods and Results-We investigated whether dietary salt restriction might ameliorate cardiac injury in DahlS. Z-Leprfa/Leprfa (DS/ obese) rats, which are derived from a cross between Dahl salt-sensitive and Zucker rats and represent a model of metabolic syndrome. DS/obese rats were fed a normal-salt (0.36% NaCl in chow) or low-salt (0.0466% NaCl in chow) diet from 9 weeks of age and were compared with similarly treated homozygous lean littermates (DahlS. Z-Lepr+/Lepr+, or DS/lean rats). DS/ obese rats fed the normal-salt diet progressively developed hypertension and showed left ventricular hypertrophy, fibrosis, and diastolic dysfunction at 15 weeks. Dietary salt restriction attenuated all of these changes in DS/obese rats. The levels of cardiac oxidative stress and inflammation and the expression of cardiac renin-angiotensin-aldosterone system genes were increased in DS/obese rats fed the normal-salt diet, and dietary salt restriction downregulated these parameters in both DS/obese and DS/lean rats. In addition, dietary salt restriction attenuated the increase in visceral adipose tissue inflammation and the decrease in insulin signaling apparent in DS/ obese rats without reducing body weight or visceral adipocyte size. Dietary salt restriction did not alter fasting serum glucose levels but it markedly decreased the fasting serum insulin concentration in DS/obese rats.
   Conclusions-Dietary salt restriction not only prevents hypertension and cardiac injury but also ameliorates insulin resistance, without reducing obesity, in this model of metabolic syndrome.
C1 [Hattori, Takuya; Murase, Tamayo; Takatsu, Miwa; Nagasawa, Kai; Matsuura, Natsumi; Watanabe, Shogo; Nagata, Kohzo] Nagoya Univ, Grad Sch Med, Dept Pathophysiol Lab Sci, Nagoya, Aichi, Japan.
   [Murohara, Toyoaki] Nagoya Univ, Grad Sch Med, Dept Cardiol, Nagoya, Aichi, Japan.
C3 Nagoya University; Nagoya University
RP Nagata, K (corresponding author), Nagoya Univ, Grad Sch Med, Dept Pathophysiol Lab Sci, Higashi Ku, 1-1-20 Daikominami, Nagoya, Aichi 4618673, Japan.
EM nagata@met.nagoya-u.ac.jp
RI Murohara, Toyoaki/M-4958-2014
FU Nippon Boehringer Ingelheim Co, Ltd (Tokyo, Japan); Ajinomoto
   Pharmaceuticals Co, Ltd (Tokyo, Japan); Kyowa Hakko Kirin Co Ltd (Tokyo,
   Japan); Astellas Pharma Inc (Tokyo, Japan); Mochida Pharmaceutical Co,
   Ltd (Tokyo, Japan); Mitsubishi Tanabe Pharma Corporation (Osaka, Japan);
   Takeda Pharmaceutical Company Limited (Osaka, Japan); Daiichi-Sankyo
   Company, Limited (Tokyo, Japan); Japanese Government
FX This work was supported by unrestricted research grants from Nippon
   Boehringer Ingelheim Co, Ltd (Tokyo, Japan), Ajinomoto Pharmaceuticals
   Co, Ltd (Tokyo, Japan), Kyowa Hakko Kirin Co Ltd (Tokyo, Japan),
   Astellas Pharma Inc (Tokyo, Japan), Mochida Pharmaceutical Co, Ltd
   (Tokyo, Japan), Mitsubishi Tanabe Pharma Corporation (Osaka, Japan),
   Takeda Pharmaceutical Company Limited (Osaka, Japan), Daiichi-Sankyo
   Company, Limited (Tokyo, Japan) and Dr Nagata (Nagoya University) as
   well as by Management Expenses Grants from the Japanese Government to
   Nagoya University.
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NR 44
TC 38
Z9 39
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2047-9980
J9 J AM HEART ASSOC
JI J. Am. Heart Assoc.
PD DEC
PY 2014
VL 3
IS 6
AR e001312
DI 10.1161/JAHA.114.001312
PG 14
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA V61EX
UT WOS:000210882600026
PM 25468654
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Banderas, DZ
   Escobedo, J
   Gonzalez, E
   Liceaga, MG
   Ramírez, JC
   Castro, MG
AF Zaineff Banderas, Diana
   Escobedo, Jorge
   Gonzalez, Evangelina
   Gabriela Liceaga, Maria
   Cenobio Ramirez, Jesus
   Guadalupe Castro, Maria
TI γ-Glutamyl transferase: a marker of nonalcoholic fatty liver disease in
   patients with the metabolic syndrome
SO EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
LA English
DT Article
DE gamma-glutamyltransferase; metabolic syndrome; nonalcoholic fatty liver
   disease; population-based cross-sectional study; risk factors
ID ALANINE AMINOTRANSFERASE; INSULIN-RESISTANCE; VISCERAL FAT; HEART; MEN;
   DEFINITION; PREDICTOR; SEVERITY; EVENTS; HEALTH
AB Objective The incidence of metabolic syndrome has increased in Mexico and nonalcoholic fatty liver disease (NAFLD) is a common complication. The authors aimed to evaluate the role of hepatic enzymes as biomarkers for NAFLD in patients presenting metabolic syndrome.
   Methods We studied 193 nondiabetic individuals with metabolic syndrome identified from a population-based cross-sectional survey. To identify NAFLD, real-time gray-scale abdominal ultrasound was performed, and the right, left, and caudate hepatic lobules were observed to assess the size, echogenicity, and borders of the liver. All individuals answered a questionnaire for risk factors, and anthropometric measures and blood pressure were obtained. The concentration of hepatic enzymes and insulin in blood was measured and the Homeostatic Model Assessment index was calculated.
   Results A total of 160 individuals were identified as presenting NAFLD (82.9%). Body weight, BMI, and the waist-hip ratio increased as a direct result of the presence and severity of fatty liver. A similar situation was observed in the levels of triglyceride and hepatic enzymes aspartate aminotransferase and gamma-glutamyltransferase (GGT), basal insulin level, and the Homeostatic Model Assessment index. In a multivariate model, the variables associated with the occurrence of NAFLD were sex, triglyceride and GGT levels, and obesity.
   Conclusion The main factors that predict the occurrence of NAFLD are levels of triglyceride and GGT in the blood, as well as obesity. The accumulation of fat in the liver, in addition to increased oxidation and oxidative stress at the hepatic level, may be the mechanisms through which these factors increase the risk of NAFLD. Eur J Gastroenterol Hepatol 24:805-810 (c) 2012 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
C1 [Escobedo, Jorge; Gonzalez, Evangelina] Mexican Inst Social Secur, Reg Hosp 1, Clin Res Ctr, Mexico City 03100, DF, Mexico.
   [Zaineff Banderas, Diana; Escobedo, Jorge; Gabriela Liceaga, Maria; Guadalupe Castro, Maria] Mexican Inst Social Secur, Dept Internal Med, Mexico City 03100, DF, Mexico.
   [Cenobio Ramirez, Jesus] Mexican Inst Social Secur, La Raza Med Ctr, Gen Hosp, Dept Radiol, Mexico City 03100, DF, Mexico.
C3 Instituto Mexicano del Seguro Social; Instituto Mexicano del Seguro
   Social; Instituto Mexicano del Seguro Social
RP Escobedo, J (corresponding author), Mexican Inst Social Secur, Reg Hosp 1, Clin Res Ctr, Gabriel Mancera 222, Mexico City 03100, DF, Mexico.
EM jorgeep@unam.mx
RI Escobedo, Jorge/AAH-3917-2020
OI Banderas Lares, Diana Zaineff/0000-0002-8186-3101; Castro, Maria
   Graciela/0000-0003-2237-2756; Escobedo, Jorge/0000-0003-1942-7402
CR André P, 2007, DIABETES CARE, V30, P2355, DOI 10.2337/dc07-0440
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NR 27
TC 51
Z9 60
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0954-691X
EI 1473-5687
J9 EUR J GASTROEN HEPAT
JI Eur. J. Gastroenterol. Hepatol.
PD JUL
PY 2012
VL 24
IS 7
BP 805
EP 810
DI 10.1097/MEG.0b013e328354044a
PG 6
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 956HN
UT WOS:000305080800012
PM 22546752
DA 2025-06-11
ER

PT J
AU Goodrich, KM
   Fundaro, G
   Griffin, LE
   Grant, A
   Hulver, MW
   Ponder, MA
   Neilson, AP
AF Goodrich, Katheryn M.
   Fundaro, Gabrielle
   Griffin, Laura E.
   Grant, Ar'Quette
   Hulver, Matthew W.
   Ponder, Monica A.
   Neilson, Andrew P.
TI Chronic administration of dietary grape seed extract increases colonic
   expression of gut tight junction protein occludin and reduces fecal
   calprotectin: a secondary analysis of healthy Wistar Furth rats
SO NUTRITION RESEARCH
LA English
DT Article
DE Calprotectin; Colon; Endotoxins; Grape seed extract; Metabolic syndrome;
   Obesity; Procyanidin; Tight junctions; Wistar Furth rat
ID HIGH-FAT-DIET; INTESTINAL PERMEABILITY; INDUCED OBESITY;
   GASTROINTESTINAL-TRACT; MICROBIAL ECOLOGY; OXIDATIVE STRESS;
   SKELETAL-MUSCLE; GENE-EXPRESSION; PREVENT OBESITY; ADIPOSE-TISSUE
AB Animal studies have demonstrated the potential of grape seed extract (GSE) to prevent metabolic syndrome, obesity, and type 2 diabetes. Recently, metabolic endotoxemia induced by bacterial endotoxins produced in the colon has emerged as a possible factor in the etiology of metabolic syndrome. Improving colonic barrier function may control endotoxemia by reducing endotoxin uptake. However, the impact of GSE on colonic barrier integrity and endotoxin uptake has not been evaluated. We performed a secondary analysis of samples collected from a chronic GSE feeding study with pharmacokinetic end points to examine potential modulation of biomarkers of colonic integrity and endotoxin uptake. We hypothesized that a secondary analysis would indicate that chronic GSE administration increases colonic expression of intestinal tight junction proteins and reduces circulating endotoxin levels, even in the absence of an obesity-promoting stimulus. Wistar Furth rats were administered drinking water containing 0.1% GSE for 21 days. Grape seed extract significantly increased the expression of gut junction protein occludin in the proximal colon and reduced fecal levels of the neutrophil protein calprotectin, compared with control. Grape seed extract did not significantly reduce serum or fecal endotoxin levels compared with control, although the variability in serum levels was widely increased by GSE. These data suggest that the improvement of gut barrier integrity and potential modulation of endotoxemia warrant investigation as a possible mechanism by which GSE prevents metabolic syndrome and associated diseases. Further investigation of this mechanism in high-fat feeding metabolic syndrome and obesity models is therefore justified. (C) 2012 Elsevier Inc. All rights reserved.
C1 [Goodrich, Katheryn M.; Griffin, Laura E.; Grant, Ar'Quette; Ponder, Monica A.; Neilson, Andrew P.] Virginia Polytech Inst & State Univ, Dept Food Sci & Technol, Blacksburg, VA 24061 USA.
   [Fundaro, Gabrielle; Hulver, Matthew W.] Virginia Polytech Inst & State Univ, Dept Human Nutr Foods & Exercise, Blacksburg, VA 24061 USA.
C3 Virginia Polytechnic Institute & State University; Virginia Polytechnic
   Institute & State University
RP Neilson, AP (corresponding author), Virginia Polytech Inst & State Univ, Dept Food Sci & Technol, Blacksburg, VA 24061 USA.
EM andrewn@vt.edu
RI Griffin, Laura/K-9057-2019
OI Griffin, Laura/0000-0002-9808-5019; Neilson, Andrew/0000-0001-5497-663X
FU Department of Food Science and Technology; College of Agriculture and
   Life Sciences
FX The authors thank Pamela Mohr, Pam Suroski, and Charles Nwaihesie for
   their assistance with animal husbandry. This study was supported by the
   Department of Food Science and Technology and the College of Agriculture
   and Life Sciences through startup funds provided to Andrew Neilson at
   Virginia Polytechnic Institute and State University.
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NR 43
TC 43
Z9 57
U1 2
U2 30
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0271-5317
J9 NUTR RES
JI Nutr. Res.
PD OCT
PY 2012
VL 32
IS 10
BP 787
EP 794
DI 10.1016/j.nutres.2012.09.004
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 044VX
UT WOS:000311654400008
PM 23146776
DA 2025-06-11
ER

PT J
AU Vaudo, G
   Marchesi, S
   Siepi, D
   Brozzetti, M
   Mannarino, MR
   Pirro, M
   Schillaci, G
   Ciuffetti, G
   Lupattelli, G
   Mannarino, E
AF Vaudo, Gaetano
   Marchesi, Simona
   Siepi, Donatella
   Brozzetti, Matteo
   Mannarino, Massimo Raffaele
   Pirro, Matteo
   Schillaci, Giuseppe
   Ciuffetti, Giovanni
   Lupattelli, Graziana
   Mannarino, Elmo
TI Metabolic syndrome and preclinical atherosclerosis: focus on femoral
   arteries
SO METABOLISM-CLINICAL AND EXPERIMENTAL
LA English
DT Article
ID INTIMA-MEDIA THICKNESS; HIGH-DENSITY-LIPOPROTEINS; MIDDLE-AGED MEN;
   CAROTID-ARTERY; NITRIC-OXIDE; ENDOTHELIAL DYSFUNCTION;
   CARDIOVASCULAR-DISEASE; LIPID-PEROXIDATION; INSULIN-RESISTANCE;
   OXIDATIVE STRESS
AB Several evidences revealed the relationship between the earliest stages of atherosclerosis and the components of metabolic syndrome. The aim of this study was to disclose preclinical atherosclerotic lesions in a cross-sectional observational study involving 147 patients with metabolic syndrome by the assessment of brachial flow mediated vasodilation (FMV) and intima-media thickening at both carotid and femoral sites. The purpose was to investigate the association of this metabolic disorder with prevalent atherosclerotic damage in different vascular sites. A control group of 87 healthy subjects was also investigated. Patients had lower values of FMV and a higher mean intima-media thickness (IMT) at both the carotid and femoral sites with respect to controls. Flow-mediated vasodilation had a positive correlation with high-density lipoprotein (HDL) cholesterol and a negative one with low-density lipoprotein (LDL) cholesterol, glycemia, and insulinemia. Carotid mean IMT was directly related to LDL cholesterol and age, and inversely with HDL cholesterol; femoral mean IMT had a direct association with LDL cholesterol, triglycerides, glycemia, and insulinemia and an inverse correlation with HDL cholesterol and LDL size. LDL cholesterol, HDL cholesterol, insulin, and brachial artery diameter were predictive of brachial FMV (beta = -0.17, 0.21, -0.27, and -0.29, respectively; P < .05), whereas age, LDL cholesterol, and HDL cholesterol were independent predictors of mean carotid IMT (beta = 0.19, 0.37, and -0.27, respectively; P < .05); on the other hand, LDL cholesterol, triglycerides, and insulin were independent predictors of mean femoral IMT (beta = 0.32, 0.26, and 0.25, respectively; P < .05). In conclusion, the present study documented an altered endothelial function and intima-media thickening in patients with metabolic syndrome without overt cardiovascular disease. Moreover, it focused on the strong influence of metabolic syndrome on preclinical atherosclerotic lesions at the femoral site. (c) 2007 Elsevier Ins. All rights reserved.
C1 Univ Perugia, Sch Med, S Maria Misericordia Hosp, I-06100 Perugia, Italy.
C3 University of Perugia
RP Vaudo, G (corresponding author), Univ Perugia, Sch Med, S Maria Misericordia Hosp, Piazzale Menghini 1, I-06100 Perugia, Italy.
EM gvaudo@unipg.it
RI Vaudo, Gaetano/AAC-4823-2022; Pirro, Matteo/AAC-2318-2022; Mannarino,
   Massimo Raffaele/AAX-6002-2021; Mannarino, Massimo Raffaele/J-4577-2012
OI Mannarino, Massimo Raffaele/0000-0003-4694-5504; Pirro,
   Matteo/0000-0002-5527-4821; Vaudo, Gaetano/0000-0002-3176-2038;
   mannarino, elmo/0000-0002-9771-8056
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NR 41
TC 18
Z9 19
U1 0
U2 1
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0026-0495
EI 1532-8600
J9 METABOLISM
JI Metab.-Clin. Exp.
PD APR
PY 2007
VL 56
IS 4
BP 541
EP 546
DI 10.1016/j.metabol.2006.11.016
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 153CJ
UT WOS:000245409000018
PM 17379014
DA 2025-06-11
ER

PT J
AU Pal, R
   Singh, SN
   Chatterjee, A
   Saha, M
AF Pal, Rameswar
   Singh, Som Nath
   Chatterjee, Abhirup
   Saha, Mantu
TI Age-related changes in cardiovascular system, autonomic functions, and
   levels of BDNF of healthy active males: role of yogic practice
SO AGE
LA English
DT Article
DE Yoga; Aging; Cardiovascular system; Autonomic function; BDNF
ID HEART-RATE-VARIABILITY; BLOOD-PRESSURE; OXIDATIVE STRESS; LIPID PROFILE;
   EXERCISE; MEDITATION; TRIAL; COGNITION; INDEXES; WEIGHT
AB Aging is associated with decline in cardiovascular, autonomic function, and brain-derived neurotropic factor (BDNF). Reports are scanty regarding whether yoga can improve age-related degenerative changes in healthy active men. This study is designed to appraise the role of yoga in improving age-related degenerative changes in cardiometabolic risk profile, autonomic function, stress, and BDNF. Healthy active males of three age groups (20-29, 30-39, and 40-49 years) were randomly assigned to practice yoga daily 1 h for 3 months. Significantly higher values of heart rate (HR), blood pressure (BP), load in heart (DoP), myocardial oxygen consumption (RPP), and total cholesterol (TC) were noted in senior age group. HR, BP, DoP, RPP, and TC decreased significantly following yogic practice. High frequency (HF), total power (TP), all time domain variables of heart rate variability (HRV), and skin conductance (SC) were significantly decreased with advancement of age. HF, TP, and time domain parameters of HRV and SC increased significantly following yogic practice. Higher levels of catecholamines and low frequency (LF) power of HRV was noted with advancement of age. Levels of catecholamines and LF significantly decreased following yogic practice. Cortisol and adrenocorticotropic hormone (ACTH) level raised in senior age group. BDNF, serotonin, and dopamine were low in higher age group. Significant decrement of cortisol; ACTH; and increment in serotonin, dopamine, and BDNF was noted following yogic practice. This study revealed that yogic practices might help in the prevention of age-related degeneration by changing cardiometabolic risk factors, autonomic function, and BDNF in healthy male.
C1 [Pal, Rameswar; Chatterjee, Abhirup] Def Inst Physiol & Allied Sci DIPAS, Ctr Adv Res & Training Yoga CARTY, Delhi 110054, India.
   [Singh, Som Nath] Def Inst Physiol & Allied Sci DIPAS, Nutr Div, Delhi 110054, India.
   [Saha, Mantu] Def Inst Physiol & Allied Sci DIPAS, Delhi 110054, India.
C3 Defence Research & Development Organisation (DRDO); Defence Institute of
   Physiology & Allied Sciences (DIPAS); Defence Research & Development
   Organisation (DRDO); Defence Institute of Physiology & Allied Sciences
   (DIPAS); Defence Research & Development Organisation (DRDO); Defence
   Institute of Physiology & Allied Sciences (DIPAS)
RP Saha, M (corresponding author), Def Inst Physiol & Allied Sci DIPAS, Lucknow Rd, Delhi 110054, India.
EM wpy.dipas@gmail.com
RI Saha, Mantu/V-8424-2019; Pal, Rameswar/AAU-5337-2020
OI Pal, Rameswar/0000-0001-6452-0951; Chatterjee, Dr
   Abhirup/0000-0001-5777-5390
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NR 70
TC 67
Z9 74
U1 0
U2 48
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0161-9152
EI 1574-4647
J9 AGE
JI Age
PD AUG
PY 2014
VL 36
IS 4
AR 9683
DI 10.1007/s11357-014-9683-7
PG 17
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA AR8BR
UT WOS:000343801100020
PM 25012275
OA Green Published
DA 2025-06-11
ER

PT J
AU Khademi, R
   Mirzaei, A
   Mirzaei, A
   Edjlali, FR
   Askari, VR
   Rahimi, VB
AF Khademi, Reza
   Mirzaei, Ali
   Mirzaei, Amirhossein
   Edjlali, Farid Reza
   Askari, Vahid Reza
   Rahimi, Vafa Baradaran
TI Morin, as a natural flavonoid, provides promising influences against
   cardiovascular diseases
SO NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
LA English
DT Review
DE Morin; Cardiovascular; Heart; Inflammation; Antioxidant
ID OXIDATIVE STRESS; ENDOTHELIAL DYSFUNCTION; MYOCARDIAL-INFARCTION; RATS;
   ANTIOXIDANT; CELLS; HEART; DOXORUBICIN; EXPRESSION; HYDRATE
AB The present investigation evaluated the potential impacts of morin, a natural flavonoid, against cardiovascular disorders. Since inception until September 2024, PubMed, Scopus, and Web of Science have been searched extensively. The process involved eliminating duplicate entries and conducting a systematic review of the remaining studies post-full-text screening. The search was conducted with meticulousness and in adherence to established protocols. Morin has shown various cardioprotective effects in experimental models. It reduces oxidative stress, inflammation, and tissue damage in conditions like myocardial ischemia, injury, and infarction. It also mitigates the harmful effects of toxins and improves hemodynamic parameters, antioxidant levels, and cardiac function. Moreover, it can address conditions like chronic iron overload and metabolic syndrome. Its mechanisms of action involve regulating signaling pathways, promoting autophagy, and reducing oxidative stress and inflammation. Morin hydrate is promising as a therapeutic agent for cardiovascular and related disorders. Morin Hydrate exhibits promising cardioprotective properties, effectively reducing oxidative stress and inflammation in myocardial conditions while also countering the effects of toxins and improving heart function. Additionally, it holds the potential for addressing chronic iron overload and metabolic syndrome. Its multifaceted mechanisms, including signaling pathway regulation and promotion of autophagy, highlight its therapeutic potential for various cardiovascular and related disorders.
C1 [Khademi, Reza; Mirzaei, Ali; Mirzaei, Amirhossein] Mashhad Univ Med Sci, Student Res Comm, Fac Med, Mashhad, Iran.
   [Khademi, Reza; Mirzaei, Ali; Mirzaei, Amirhossein; Edjlali, Farid Reza; Rahimi, Vafa Baradaran] Mashhad Univ Med Sci, Fac Med, Dept Cardiovasc Dis, Mashhad, Iran.
   [Askari, Vahid Reza] Mashhad Univ Med Sci, Pharmacol Res Ctr Med Plants, Mashhad, Iran.
C3 Mashhad University of Medical Sciences; Mashhad University of Medical
   Sciences; Mashhad University of Medical Sciences
RP Rahimi, VB (corresponding author), Mashhad Univ Med Sci, Fac Med, Dept Cardiovasc Dis, Mashhad, Iran.
EM Rezakhademi2001@gmail.com; Alimirzaei8001@gmail.com;
   mirzaeiah1998@gmail.com; fr.edjlali@gmail.com;
   vahidrezaaskary@gmail.com; baradaranrv@mums.ac.ir
RI Baradaran Rahimi, Vafa/AAR-4523-2021; Khademi, Reza/HTP-8711-2023;
   Askari, Vahid Reza/ABB-8991-2020
OI Khademi, Reza/0009-0001-5857-8003
FU Mashhad University of Medical Sciences, Mashhad, Iran
FX The research was supported by Mashhad University of Medical Sciences,
   Mashhad, Iran.
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NR 52
TC 1
Z9 1
U1 4
U2 4
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0028-1298
EI 1432-1912
J9 N-S ARCH PHARMACOL
JI Naunyn-Schmiedebergs Arch. Pharmacol.
PD JUN
PY 2025
VL 398
IS 6
BP 6293
EP 6310
DI 10.1007/s00210-024-03783-4
EA JAN 2025
PG 18
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 3FS1V
UT WOS:001396955400001
PM 39808314
DA 2025-06-11
ER

PT J
AU Taki, AG
   Mohammed, SA
   Allwsh, TA
AF Taki, Anmar Ghanem
   Mohammed, Shaha Abdallha
   Allwsh, Thikra Ali
TI ASPROSIN: RELATION TO OXIDATIVE STRESS FOR METABOLIC SYNDROME PATIENTS
   IN MOSUL/IRAQ
SO PERIODICO TCHE QUIMICA
LA English
DT Article
DE Asprosin Hormone; Oxidative Stress; Metabolic Syndrome; Insulin
   Resistance; total antioxidant capacity
AB Background: Asprosin is a protein hormone important in regulating appetite; glucose and lipid metabolites are secreted during fasting. Aims: The present study investigates the relationship between asprosin level and oxidative stress in MetS. Methods: The study included 171 participants persons aged 35-65 years who were divided into two groups: a control group, which included 75 participants, and a patient group, which included 95 participants from patients getting treatment at the Ibn Sina Educational Hospital in the Iraqi city of Mosul. Ethical approval was obtained from the Iraqi Ministry of Health- Nineveh Health. Five milliliters of venous blood were taken following a fast for an entire night. To perform oxidative and antioxidative factor tests as well as clinical evaluations. Results: Asprosin hormone levels in MetS significantly increased, but a significant decrease of antioxidative (glutathione, total antioxidant capacity, and arylesterase) also A substantial rise in malondialdehyde, lactoperoxidase, and peroxidase. It was found through the linear correlation coefficient (R) that there was a significant positive correlation between asprosin and oxidative and an inverse correlation with antioxidative variables. Discussion: These findings imply that asprosin is an indicator of metabolic disorders and is associated with MetS and oxidative stress indicators. Conclusions: Therefore, it can be considered a new indicator and a promising tool for diagnosis and treatment to initiate and develop.
C1 [Taki, Anmar Ghanem] Al Noor Univ Coll, Dept Radiol & Sonar Tech, Mosul, Iraq.
   [Mohammed, Shaha Abdallha] Ibn Sina Teaching Hosp, Biochem Lab, Mosul, Iraq.
   [Allwsh, Thikra Ali] Univ Mosul, Dept Chem, Collage Sci, Mosul, Iraq.
C3 Alnoor University; University of Mosul
RP Allwsh, TA (corresponding author), Univ Mosul, Dept Chem, Collage Sci, Mosul, Iraq.
EM thekraaliallwsh@uomosul.edu.iq
RI Allwsh, Thikra/ISA-6950-2023
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NR 35
TC 0
Z9 0
U1 1
U2 1
PU TCHE QUIMICA GROUP
PI PORTO ALEGRE RS
PA 359 ANITA GARIBALDI ST, RM 603, PORTO ALEGRE RS, 90450-001, BRAZIL
SN 1806-0374
EI 2179-0302
J9 PERIOD TCHE QUIM
JI Period. Tche Quim.
PY 2024
VL 21
IS 48
DI 10.52571/PTQ.v21.n48.2024_11_TAKI_pgs_132_139.pdf
PG 180
WC Chemistry, Multidisciplinary
WE Emerging Sources Citation Index (ESCI)
SC Chemistry
GA O6A7D
UT WOS:001371935900011
OA Bronze
DA 2025-06-11
ER

PT J
AU Terzo, S
   Mulé, F
   Amato, A
AF Terzo, Simona
   Mule, Flavia
   Amato, Antonella
TI Honey and obesity-related dysfunctions: a summary on health benefits
SO JOURNAL OF NUTRITIONAL BIOCHEMISTRY
LA English
DT Review
DE Honey; Polyphenols; Obesity; Oxidative stress; Neurodegeneration;
   Hypertension
ID HIGH-FAT DIET; IMPROVES MEMORY PERFORMANCE; NATURAL HONEY; OXIDATIVE
   STRESS; TUALANG HONEY; ANTIOXIDANT ACTIVITY; GLYCEMIC CONTROL;
   ENDOTHELIAL DYSFUNCTION; INSULIN-RESISTANCE; METABOLIC SYNDROME
AB Honey is a natural product, containing flavonoids and phenolic acids, appreciated for its therapeutic abilities since ancient times. Although the bioactive potential is linked to the composition, that is variable depending on mainly the botanical origin, honey has antioxidant and anti-inflammatory properties. Therefore, honey, administered alone or in combination with conventional therapy, might result useful in the management of chronic diseases that are commonly associated with oxidative stress and inflammation state. Obesity is a metabolic disorder characterized by visceral adiposity. The adipose tissue becomes hypertrophic and undergoes hyperplasia, resulting in a hypoxic environment, oxidative stress and production of pro-inflammatory mediators that can be responsible for other disorders, such as metabolic syndrome and neurodegeneration. Experimental evidence from animals have shown that honey improves glycemic control and lipid profile with consequent protection from endothelial dysfunction and neurodegeneration. The purpose of the present review is to summarize the current literature concerning the beneficial effects of honey in the management of the obesity-related dysfunctions, including neurodegeneration. Based on the key constituents of honey, the paper also highlights polyphenols to be potentially responsible for the health benefits of honey. Further well-designed and controlled studies are necessary to validate these benefits in humans. (C) 2020 Elsevier Inc. All rights reserved.
C1 [Terzo, Simona; Mule, Flavia; Amato, Antonella] Univ Palermo, Dept Biol Chem & Pharmaceut Sci & Technol, Palermo, Italy.
   [Terzo, Simona] Univ Palermo, Dept Neurosci & Cell Biol, Palermo, Italy.
C3 University of Palermo; University of Palermo
RP Amato, A (corresponding author), Univ Palermo, Dept Biol Chem & Pharmaceut Sci & Technol, Palermo, Italy.
EM simona.terzo01@unipa.it; flavia.mule@unipa.it; antonella.amato@unipa.it
RI Mulè, Flavia/AAX-7921-2020; Amato, Antonella/AAX-8821-2020
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NR 112
TC 34
Z9 37
U1 6
U2 46
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0955-2863
EI 1873-4847
J9 J NUTR BIOCHEM
JI J. Nutr. Biochem.
PD AUG
PY 2020
VL 82
AR 108401
DI 10.1016/j.jnutbio.2020.108401
PG 8
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA LY2SU
UT WOS:000540374200005
PM 32454412
DA 2025-06-11
ER

PT J
AU González-Montoya, M
   Vargas-Vargas, MA
   Torres-Isidro, O
   García-Berumen, CI
   Cuiniche-Méndez, MG
   Saavedra-Molina, A
   Ontiveros-Rodríguez, JC
   Garcia-Gutiérrez, HA
   Calderon-Cortés, E
   Cortés-Rojo, C
AF Gonzalez-Montoya, Marcela
   Vargas-Vargas, Manuel Alejandro
   Torres-Isidro, Olin
   Garcia-Berumen, Claudia Isabel
   Cuiniche-Mendez, Maria Guadalupe
   Saavedra-Molina, Alfredo
   Ontiveros-Rodriguez, Julio Cesar
   Garcia-Gutierrez, Hugo A.
   Calderon-Cortes, Elizabeth
   Cortes-Rojo, Christian
TI Evaluation of Unsaponifiable Fraction of Avocado Oil on Liver and Kidney
   Mitochondrial Function in Rats Fed a High-Fat and High-Carbohydrate Diet
SO METABOLITES
LA English
DT Article
DE avocado oil; unsaponifiable fraction; high-fat diet; high-carbohydrate
   diet; metabolic syndrome; mitochondria
ID INSULIN-RESISTANCE; OXIDATIVE STRESS; DYSFUNCTION; MODEL
AB High-fat and high-carbohydrate (HF-HC) diets induce metabolic syndrome via mitochondrial dysfunction and oxidative stress. We have previously shown that this may be prevented by avocado oil, a source of bioactive molecules with antioxidant properties. However, it is unknown if these effects are mediated by the unsaponifiable fraction of avocado oil (UFAO). Thus, we tested if this fraction improves glucose metabolism, bioenergetics and oxidative stress in mitochondria from the kidney and liver of rats fed an HF-HC diet. We found that 12 weeks of an HF-HC diet impaired glucose utilization and increased insulin resistance, which was prevented by UFAO administration. The HF-HC diet decreased respiration, membrane potential and electron transport chain (ETC) function in liver and kidney mitochondria. These mitochondrial dysfunctions were prevented by UFAO intake. Unexpectedly, UFAO increased ROS levels in the mitochondria of control animals and did not decrease them in rats with an HF-HC diet; however, UFAO protects liver and kidney mitochondria from iron-induced oxidative stress. These findings suggest that impairments in glucose metabolism and mitochondrial function by an HF-HC diet may be prevented by UFAO, without decreasing ROS generation but protecting mitochondria from oxidative damage.
C1 [Gonzalez-Montoya, Marcela; Vargas-Vargas, Manuel Alejandro; Torres-Isidro, Olin; Garcia-Berumen, Claudia Isabel; Cuiniche-Mendez, Maria Guadalupe; Saavedra-Molina, Alfredo; Garcia-Gutierrez, Hugo A.; Cortes-Rojo, Christian] Univ Michoacana, Inst Invest Quim Biol, Morelia 58030, MC, Mexico.
   [Ontiveros-Rodriguez, Julio Cesar] Univ Michoacana, Consejo Nacl Human Ciencias & Tecnol, Inst Invest Quim Biol, Morelia 58030, MC, Mexico.
   [Calderon-Cortes, Elizabeth] Univ Michoacana, Fac Enfermeria, Morelia 58020, MC, Mexico.
C3 Universidad Michoacana de San Nicolas de Hidalgo; Universidad Michoacana
   de San Nicolas de Hidalgo; Universidad Michoacana de San Nicolas de
   Hidalgo
RP González-Montoya, M; Cortés-Rojo, C (corresponding author), Univ Michoacana, Inst Invest Quim Biol, Morelia 58030, MC, Mexico.
EM marceglezmon@gmail.com; 1371614e@umich.mx; 1584209e@umich.mx;
   0620929h@umich.mx; 1900220g@umich.mx; francisco.saavedra@umich.mx;
   julio.ontiveros@umich.mx; hgarcia@umich.mx; elizabeth.calderon@umich.mx;
   christian.cortes@umich.mx
RI García, Hugo/AAE-6351-2020; Cortes, Christian./ABF-4312-2021
OI Garcia-Gutierrez, Hugo A./0000-0003-2841-0135; GONZALEZ MONTOYA,
   MARCELA/0000-0001-9604-5622; Vargas Vargas, Manuel
   Alejandro/0000-0003-3239-123X; Cortes-Rojo,
   Christian/0000-0002-4850-772X; Saavedra-Molina,
   Alfredo/0000-0002-0811-2950; TORRES ISIDRO, OLIN/0009-0004-8813-5619
FU Instituto de Ciencia, Tecnologia e Innovacion-Gobierno del Estado de
   Michoacan [ICTI-PICIR23-063, ICTI PICIR23-028]; Programa Proyectos de
   Investigacion financiados 2024, Coordinacion de Investigacion
   Cientifica, Universidad Michoacana de San Nicolas de Hidalgo, Mexico
   [7973911]; Estancias Posdoctorales por Mexico [472544, 589763]; Consejo
   Nacional de Humanidades, Ciencia y Tecnologia (CONAHCYT)
FX This research was supported by Instituto de Ciencia, Tecnologia e
   Innovacion-Gobierno del Estado de Michoacan, No. ICTI-PICIR23-063 and
   No. ICTI PICIR23-028; and Programa Proyectos de Investigacion
   financiados 2024, Coordinacion de Investigacion Cientifica, Universidad
   Michoacana de San Nicolas de Hidalgo (7973911), Mexico. Estancias
   Posdoctorales por Mexico 2022 (472544) and 2023 (589763), Consejo
   Nacional de Humanidades, Ciencia y Tecnologia (CONAHCYT).
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Z9 1
U1 3
U2 5
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2218-1989
J9 METABOLITES
JI Metabolites
PD AUG
PY 2024
VL 14
IS 8
AR 431
DI 10.3390/metabo14080431
PG 18
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA E8W4G
UT WOS:001305744700001
PM 39195527
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Liao, MT
   Sung, CC
   Hung, KC
   Wu, CC
   Lo, L
   Lu, KC
AF Liao, Min-Tser
   Sung, Chih-Chien
   Hung, Kuo-Chin
   Wu, Chia-Chao
   Lo, Lan
   Lu, Kuo-Cheng
TI Insulin Resistance in Patients with Chronic Kidney Disease
SO JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY
LA English
DT Review
ID ENDOPLASMIC-RETICULUM STRESS; FETUIN-A LEVELS; DENSITY-LIPOPROTEIN
   CHOLESTEROL; METABOLIC RISK-FACTORS; VITAMIN-D; GLUCOSE-TOLERANCE;
   MAINTENANCE HEMODIALYSIS; CARDIOVASCULAR-DISEASE; SKELETAL-MUSCLE;
   ENDOTHELIAL DYSFUNCTION
AB Metabolic syndrome and its components are associated with chronic kidney disease (CKD) development. Insulin resistance (IR) plays a central role in the metabolic syndrome and is associated with increased risk for CKD in nondiabetic patients. IR is common in patients with mild-to-moderate stage CKD, even when the glomerular filtration rate is within the normal range. IR, along with oxidative stress and inflammation, also promotes kidney disease. In patients with end stage renal disease, IR is an independent predictor of cardiovascular disease and is linked to protein energy wasting and malnutrition. Systemic inflammation, oxidative stress, elevated serum adipokines and fetuin-A, metabolic acidosis, vitamin D deficiency, depressed serum erythropoietin, endoplasmic reticulum stress, and suppressors of cytokine signaling all cause IR by suppressing insulin receptor-PI3K-Akt pathways in CKD. In addition to adequate renal replacement therapy and correction of uremia-associated factors, thiazolidinedione, ghrelin, protein restriction, and keto-acid supplementation are therapeutic options. Weight control, reduced daily prednisolone dosage, and the use of cyclosporin decrease the risk of developing new-onset diabetes after kidney transplantation. Improved understanding of the pathogenic mechanisms underlying IR in CKD may lead to more effective therapeutic strategies to reduce uremia-associated morbidity and mortality.
C1 [Hung, Kuo-Chin; Lo, Lan; Lu, Kuo-Cheng] Fu Jen Catholic Univ, Cardinal Tien Hosp, Sch Med, Dept Med,Div Nephrol, New Taipei City 242, Taiwan.
   [Liao, Min-Tser] Taoyuan Armed Forces Gen Hosp, Dept Pediat, Tao Yuan 325, Taiwan.
   [Liao, Min-Tser] Triserv Gen Hosp, Natl Def Med Ctr, Dept Pediat, Taipei 114, Taiwan.
   [Sung, Chih-Chien] Triserv Gen Hosp, Natl Def Med Ctr, Dept Med, Div Nephrol, Taipei 114, Taiwan.
C3 Fu Jen Catholic University; Cardinal Tien Hospital; National Defense
   Medical Center; Tri-Service General Hospital; Tri-Service General
   Hospital; National Defense Medical Center
RP Lu, KC (corresponding author), Fu Jen Catholic Univ, Cardinal Tien Hosp, Sch Med, Dept Med,Div Nephrol, New Taipei City 242, Taiwan.
EM kuochenglu@gmail.com
RI Wu, Changzhi/D-6413-2017
FU Cardinal-Tien Hospital [CTH-99-1-2A06]; Teh-Tzer Study Group for Human
   Medical Research Foundation [B-99-10-53]
FX The Research Fund from Cardinal-Tien Hospital (CTH-99-1-2A06) and
   Teh-Tzer Study Group for Human Medical Research Foundation (B-99-10-53)
   supported this study.
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NR 138
TC 97
Z9 103
U1 0
U2 20
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1110-7243
EI 1110-7251
J9 J BIOMED BIOTECHNOL
JI J. Biomed. Biotechnol.
PY 2012
AR 691369
DI 10.1155/2012/691369
PG 12
WC Biotechnology & Applied Microbiology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Research & Experimental Medicine
GA 997UG
UT WOS:000308191600001
PM 22919275
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Fukushima, M
   Okamoto, Y
   Katsumata, H
   Ishikawa, M
   Ishii, S
   Okamoto, M
   Minami, S
AF Fukushima, M.
   Okamoto, Y.
   Katsumata, H.
   Ishikawa, M.
   Ishii, S.
   Okamoto, M.
   Minami, S.
TI Growth Hormone Ameliorates Adipose Dysfunction During Oxidative Stress
   and Inflammation and Improves Glucose Tolerance in Obese Mice
SO HORMONE AND METABOLIC RESEARCH
LA English
DT Article
DE growth hormone; adipose tissue; oxidative stress; inflammation;
   adiponectin; glucose tolerance
ID DIET-INDUCED OBESITY; METABOLIC SYNDROME; BODY-COMPOSITION;
   INSULIN-RESISTANCE; CRUCIAL ROLE; MOUSE MODEL; IGF-I; ADIPONECTIN;
   TISSUE; FAT
AB Patients with adult growth hormone deficiency exhibit visceral fat accumulation, which gives rise to a cluster of metabolic disorders such as impaired glucose tolerance and dyslipidemia. Plasma growth hormone levels are lower in obese patients with metabolic syndrome than in healthy subjects. Here we examined the hypothesis that exogenous growth hormone administration regulates function of adipose tissue to improve glucose tolerance in diet-induced obese mice. Twelve-week-old obese male C57BL/6J mice received bovine growth hormone daily for 6 weeks. In epididymal fat, growth hormone treatment antagonized diet-induced changes in the gene expression of adiponectin, leptin, and monocyte chemoattractant protein-1, and significantly increased the gene expression of interleukin-10 and CD206. Growth hormone also suppressed the accumulation of oxidative stress marker, thiobarbituric acid-reactive substances, in the epididymal fat and enhanced the gene expression of anti-oxidant enzymes. Moreover, growth hormone significantly restored glucose tolerance in obese mice. In cultured 3T3-L1 adipocytes, growth hormone prevented the decline in adiponectin gene expression in the presence of hydrogen peroxide. These results suggest that growth hormone administration ameliorates glucose intolerance in obese mice presumably by decreasing adipose mass, oxidative stress, and chronic inflammation in the visceral fat.
C1 [Fukushima, M.; Okamoto, Y.; Katsumata, H.; Ishii, S.; Okamoto, M.; Minami, S.] Nippon Med Sch, Dept Bioregulat, Kawasaki, Kanagawa 2118533, Japan.
   [Okamoto, Y.; Ishikawa, M.; Minami, S.] Musashi Kosugi Hosp, Nippon Med Sch, Div Endocrinol Diabetol & Atherosclerosis Med, Kawasaki, Kanagawa, Japan.
C3 Nippon Medical School; Nippon Medical School
RP Okamoto, Y (corresponding author), Nippon Med Sch, Dept Bioregulat, Nakahara Ku, 1-396 Kosugi Machi, Kawasaki, Kanagawa 2118533, Japan.
EM yokamoto@nms.ac.jp
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NR 35
TC 12
Z9 12
U1 0
U2 2
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0018-5043
EI 1439-4286
J9 HORM METAB RES
JI Horm. Metab. Res.
PD AUG
PY 2014
VL 46
IS 9
BP 656
EP 662
DI 10.1055/s-0034-1381998
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA AO1UI
UT WOS:000341100000010
PM 24995855
DA 2025-06-11
ER

PT J
AU Cesarone, MR
   Di Renzo, A
   Errichi, S
   Schönlau, F
   Wilmer, JL
   Blumenfeld, J
AF Cesarone, Maria R.
   Di Renzo, Andrea
   Errichi, Silvia
   Schonlau, Frank
   Wilmer, James L.
   Blumenfeld, Julian
TI Improvement in circulation and in cardiovascular risk factors with a
   proprietary isotonic bioflavonoid formula OPC-3®
SO ANGIOLOGY
LA English
DT Article
DE bioflavonoid; OPC-3; metabolic syndrome; isotonic; cardiovascular risk
   factors; pycnogenol
ID OXIDATIVE STRESS; POLYPHENOLS; ANTIOXIDANTS; PREVENTION; DISEASE; PLASMA
AB This study investigated the efficacy of isotonic bioflavonoid Supplementation, OPC-3 on 61 individuals presenting with risk factors meeting the criteria for metabolic syndrome. Subjects were supplemented with a proprietary isotonic bioflavonoid OPC-3 or placebo over 2 months. Plasma oxidative stress status was significantly lowered by 10.1% with OPC-3. All major cardiovascular risk factors were improved with blood pressure, total cholesterol, and Fasting blood glucose lowered. OPC-3 significantly improved endothelial function as evaluated by increased vasorelaxation in reactive hyperemia and enhanced diastolic carotid artery flow. Cardiac ultrasound scanning revealed a significant increase of left ventricular ejection fraction. Skin microcirculation was enhanced, and better tissue perfusion led to significantly increased transcutaneous Oxygen partial pressure and decreased pCO(2). With OPC-3 a dramatic and significant plasma C-reactive protein decrease by 52.1% occurred. Individuals may improve key cardiovascular risk Factors by daily Supplementation with the bioflavonoid OPC-3 as an important part of a healthier lifestyle.
C1 [Wilmer, James L.; Blumenfeld, Julian] NutraMetrix, Div Market Amer, Greensboro, NC 27409 USA.
   [Cesarone, Maria R.; Di Renzo, Andrea] Univ G dAnnunzio, Dept Biomed Sci, Pescara, Italy.
   [Schonlau, Frank] Horphag Res UK, London, England.
C3 G d'Annunzio University of Chieti-Pescara
RP Blumenfeld, J (corresponding author), NutraMetrix, Div Market Amer, 1302 Pleasant Ridge Rd, Greensboro, NC 27409 USA.
EM nutramextix@nutrametrix.com
CR [Anonymous], 2001, Altern Med Rev, V6, P500
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NR 25
TC 5
Z9 5
U1 0
U2 4
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0003-3197
EI 1940-1574
J9 ANGIOLOGY
JI Angiology
PD AUG-SEP
PY 2008
VL 59
IS 4
BP 408
EP 414
DI 10.1177/0003319708321801
PG 7
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 348YB
UT WOS:000259244900003
PM 18628275
DA 2025-06-11
ER

PT J
AU Jadhav, R
   Dodd, T
   Smith, E
   Bailey, E
   DeLucia, AL
   Russell, JC
   Madison, R
   Potter, B
   Walsh, K
   Jo, HJ
   Rocic, P
AF Jadhav, Rashmi
   Dodd, Tracy
   Smith, Erika
   Bailey, Erin
   DeLucia, Angelo L.
   Russell, James C.
   Madison, Rowan
   Potter, Barry
   Walsh, Kenneth
   Jo, Hanjoong
   Rocic, Petra
TI Angiotensin type I receptor blockade in conjunction with enhanced Akt
   activation restores coronary collateral growth in the metabolic syndrome
SO AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
LA English
DT Article
DE transient; coronary artery occlusion
ID ISCHEMIA-INDUCED ANGIOGENESIS; NITRIC-OXIDE SYNTHASE; ENDOTHELIAL-CELLS;
   KINASE; RAT; INHIBITION; STRESS; SYSTEM; ARTERY
AB Jadhav R, Dodd T, Smith E, Bailey E, DeLucia AL, Russell JC, Madison R, Potter B, Walsh K, Jo H, Rocic P. Angiotensin type I receptor blockade in conjunction with enhanced Akt activation restores coronary collateral growth in the metabolic syndrome. Am J Physiol Heart Circ Physiol 300: H1938-H1949, 2011. First published February 18, 2011; doi:10.1152/ajpheart.00282.2010.-We have previously demonstrated that Akt was required for repetitive ischemia (RI)-induced coronary collateral growth (CCG) in healthy rats but was not activated by RI in the metabolic syndrome (JCR:LA-cp rats) where CCG was impaired. Here we hypothesized that failure of angiotensin type I receptor (AT(1)R) blockers to restore Akt activation is a key determinant of their inability to completely restore CCG in the metabolic syndrome. Therefore, we investigated whether adenovirus-mediated delivery of constitutively active Akt (MyrAkt-Adv.) in conjunction with AT(1)R blockade (candesartan) was able to restore RI-induced CCG in JCR:LA-cp rats. Successful myocardial MyrAkt-Adv delivery was confirmed by a >80% transduction efficiency and an approximately fourfold increase in Akt expression and activation. CCG was assessed by myocardial blood flow measurements in the normal and collateral-dependent zones. MyrAkt-Adv alone significantly increased RI-induced CCG in JCR:LA-cp rats (similar to 30%), but it completely restored CCG in conjunction with administration of candesartan. In contrast, dominant negative Akt (DN-Akt-Adv) reversed the beneficial effect of candesartan on CCG in JCR:LA-cp rats. We conclude that optimal restoration of coronary collateral growth in JCR:LA-cp rats requires a combination of AT(1)R blockade with constitutive Akt activation. These findings may carry implications for metabolic syndrome patients in need of coronary revascularization.
C1 [Rocic, Petra] Univ S Alabama, Dept Biochem & Mol Biol, Coll Med, Mobile, AL 36688 USA.
   [Bailey, Erin; DeLucia, Angelo L.] Northeastern Ohio Univ Coll Med & Pharm, Coll Med, Dept Integrat Med Sci, Rootstown, OH 44272 USA.
   [Russell, James C.] Univ Alberta, Alberta Inst Human Nutr, Metab & Cardiovasc Dis Lab, Edmonton, AB, Canada.
   [Madison, Rowan; Potter, Barry] Louisiana State Univ, Hlth Sci Ctr, Dept Physiol, New Orleans, LA USA.
   [Walsh, Kenneth] Boston Univ, Sch Med, Whitaker Cardiovasc Inst, Boston, MA 02118 USA.
   [Jo, Hanjoong] Emory Univ, Coulter Dept Biomed Engn, Georgia Inst Technol, Atlanta, GA 30322 USA.
   [Jo, Hanjoong] Emory Univ, Dept Med, Div Cardiol, Atlanta, GA 30322 USA.
C3 University of South Alabama; University System of Ohio; Northeast Ohio
   Medical University (NEOMED); University of Alberta; Louisiana State
   University System; Louisiana State University Health Sciences Center New
   Orleans; Boston University; Emory University; University System of
   Georgia; Georgia Institute of Technology; Emory University
RP Rocic, P (corresponding author), Univ S Alabama, Dept Biochem & Mol Biol, Coll Med, 307 N Univ Blvd, Mobile, AL 36688 USA.
EM procic@usouthal.edu
RI JADHAV, RASHMI/GQI-2890-2022; Jo, Hanjoong/L-6216-2019
OI Rocic, Petra/0000-0002-5781-3075; Jo, Hanjoong/0000-0003-1833-372X
FU National Heart, Lung, and Blood Institute [R01-HL-093052]
FX This work was supported by National Heart, Lung, and Blood Institute
   Grant R01-HL-093052.
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NR 37
TC 13
Z9 15
U1 0
U2 2
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0363-6135
EI 1522-1539
J9 AM J PHYSIOL-HEART C
JI Am. J. Physiol.-Heart Circul. Physiol.
PD MAY
PY 2011
VL 300
IS 5
BP H1938
EP H1949
DI 10.1152/ajpheart.00282.2010
PG 12
WC Cardiac & Cardiovascular Systems; Physiology; Peripheral Vascular
   Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Physiology
GA 757NA
UT WOS:000290092800042
PM 21335466
OA Green Published
DA 2025-06-11
ER

PT J
AU Vergès, B
AF Vergès, B
TI Clinical interest of PPARs ligands -: Particular benefit in type 2
   diabetes and metabolic syndrome
SO DIABETES & METABOLISM
LA English
DT Review
DE diabetes; metabolic syndrome; PPAR fibrate; glitazone
ID IMPROVES GLYCEMIC CONTROL; CORONARY-HEART-DISEASE;
   PROLIFERATOR-ACTIVATED RECEPTORS; VASCULAR ENDOTHELIAL-CELLS;
   PIOGLITAZONE HYDROCHLORIDE; ROSIGLITAZONE MONOTHERAPY; GENE-EXPRESSION;
   GAMMA LIGANDS; FATTY-ACIDS; ALPHA
AB Cardiovascular disease is significantly increased in patients with metabolic syndrome and type 2 diabetes. Several factors such as chronic hyperglycemia, lipid abnormalities, endothelium dysfunction, inflammation, oxidative stress, increased thrombosis and decreased fibrinolysis are likely to promote cardiovascular events in these patients. Because of positive effects on glucose homeostasis, lipid metabolism, proteins involved in all stages of atherogenesis, endothelium function, inflammation, thrombosis and fibrinolysis, PPARS alpha (fibrates) and PPARs gamma (glitazones) agonists are good candidates to reduce cardiovascular disease, more precisely in subjects with metabolic syndrome or type 2 diabetes. PPARS a agonists (fibrates) are potent hypolipidemic agents increasing plasma HDL-cholesterol and reducing free fatty acids, triglycerides, LDL-cholesterol and the number of small dense LDL particles. Moreover, they reduce vascular inflammation and thrombosis, promote fibrinolysis and inhibit the production of the vasoconstrictor factor, endothelin-1, by the endothelium. They have been shown, in clinical trials, to reduce cardiovascular disease, more particularly in patients displaying lipid abnormalities typical of metabolic syndrome and type 2 diabetes (high triglycerides, low HDL-cholesterol). PPARS gamma agonists (glitazones) have not only beneficial effects on glucose homeostasis, by increasing insulin sensitivity and reducing blood glucose level but also on lipid metabolism by elevating plasma HDL-cholesterol, decreasing free fatty acids and the number of small dense LDL particles, and for pioglitazone by reducing plasma triglycerides. Furthermore, they diminish vascular inflammation and vasoconstriction, inhibit monocyte chemotaxis, proliferation and migration of smooth muscle cells, in the vascular wall and decrease the production of adhesion molecules and metalloproteinases. PPARs gamma agonists (glitazones) have been shown to reduce the development of atherosclerotic lesions in rats. The potential clinical benefit of PPARs gamma agonists on the reduction of cardiovascular disease, in type 2 diabetic patients, will be specified by the ongoing intervention studies.
C1 CHU Dijon, Hop Bocage, Serv Endocrinol Diabetol & Maladies Metabol, F-21000 Dijon, France.
C3 Universite Bourgogne Europe; CHU Dijon Bourgogne
RP CHU Dijon, Hop Bocage, Serv Endocrinol Diabetol & Maladies Metabol, F-21000 Dijon, France.
EM bruno.verges@chu-dijon.fr
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NR 50
TC 84
Z9 90
U1 0
U2 3
PU MASSON EDITEUR
PI MOULINEAUX CEDEX 9
PA 21 STREET CAMILLE DESMOULINS, ISSY, 92789 MOULINEAUX CEDEX 9, FRANCE
SN 1262-3636
EI 1878-1780
J9 DIABETES METAB
JI Diabetes Metab.
PD FEB
PY 2004
VL 30
IS 1
BP 7
EP 12
DI 10.1016/S1262-3636(07)70083-6
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 810IB
UT WOS:000220696900001
PM 15029092
DA 2025-06-11
ER

PT J
AU Hales, CN
   Ozanne, SE
AF Hales, CN
   Ozanne, SE
TI For Debate: Fetal and early postnatal growth restriction lead to
   diabetes, the metabolic syndrome and renal failure
SO DIABETOLOGIA
LA English
DT Article
DE Type 2 diabetes; metabolic syndrome; renal failure; fetal growth
   restriction; programming; epigenetic; longevity; telomeres; thrifty
   phenotype hypothesis; low-protein diet
ID THRIFTY PHENOTYPE HYPOTHESIS; IMPAIRED GLUCOSE-TOLERANCE; MATERNAL IRON
   RESTRICTION; PROTEIN-MALNOURISHED RATS; CORONARY-HEART-DISEASE;
   LOW-BIRTH-WEIGHT; BLOOD-PRESSURE; SIGNAL-TRANSDUCTION;
   INSULIN-RESISTANCE; ENDOCRINE PANCREAS
AB We review the progress in testing the thrifty phenotype hypothesis. Many human epidemiological studies both by ourselves and others have confirmed and extended the original observations on which the hypothesis was based. We are not aware of any contradictory findings and we emphasise the strength of the association between birth weight and the subsequent development of the metabolic syndrome. We have worked extensively experimentally to test the hypothesis in a rat model in which pregnant and/or lactating dams are fed a diet moderately restricted in proteins. The range of programming effects that we have discovered in this example of fetal and early postnatal growth restriction is listed and includes changes in hormone receptors, signalling molecules and regulatory enzymes. We have shown the model to develop diabetes, the metabolic syndrome and signs of premature renal failure. We summarise these and other similarities between the phenotype of this model and human Type 2 diabetes and the metabolic syndrome. The number of insults during early development which can lead to a similar outcome is discussed and the suggestion is made that the early life response to stress is limited in its flexibility with outcomes including ageing and decreased longevity. Our preliminary results indicate that some MODY genes could suggest pathways whereby the changes occur and that epigenetic changes during development are involved. We conclude that the way is now clear to discover early human markers of programming by early life growth restriction and to use these to devise strategies for the prevention of Type 2 diabetes.
C1 Addenbrookes Hosp, Dept Clin Biochem, Cambridge CB2 2QR, England.
   Univ Cambridge, Dept Clin Biochem, Cambridge, England.
C3 Cambridge University Hospitals NHS Foundation Trust; Addenbrooke's
   Hospital; University of Cambridge; University of Cambridge
RP Addenbrookes Hosp, Dept Clin Biochem, Hills Rd, Cambridge CB2 2QR, England.
EM chn1000@cam.ac.uk
OI Ozanne, Susan/0000-0001-8753-5144
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NR 64
TC 108
Z9 126
U1 0
U2 8
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0012-186X
EI 1432-0428
J9 DIABETOLOGIA
JI Diabetologia
PD JUL
PY 2003
VL 46
IS 7
BP 1013
EP 1019
DI 10.1007/s00125-003-1131-7
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 709VB
UT WOS:000184644300019
PM 12827239
OA Bronze
DA 2025-06-11
ER

PT J
AU Scherer, T
   Buettner, C
AF Scherer, Thomas
   Buettner, Christoph
TI The dysregulation of the endocannabinoid system in diabesity-a tricky
   problem
SO JOURNAL OF MOLECULAR MEDICINE-JMM
LA English
DT Review
DE Endocannabinoids; Leptin action; Adipose tissue; Mediobasal
   hypothalamus; Fat metabolism
ID CB1 RECEPTOR ANTAGONIST; CARDIOMETABOLIC RISK-FACTORS; ADIPOSE-TISSUE;
   OVERWEIGHT PATIENTS; GLUCOSE-UPTAKE; BODY-WEIGHT; LEPTIN; DIET; INSULIN;
   FAT
AB Endocannabinoids (ECs) are small lipid mediators that play a critical role in energy metabolism. Human studies have shown that the EC tone in peripheral tissues positively correlates with increased adiposity. Furthermore, pharmacological inhibition of EC signaling results in weight loss in humans. However, the mechanisms that cause the dysregulation of the EC system in obesity are not well-understood. Since the clinical utility of currently available EC blockers is severely limited due to their side effects like depression and suicidal ideation that are caused by central effects, it is important to delineate the role of central and peripheral effects of EC signaling in regulating glucose and lipid metabolism.
C1 [Scherer, Thomas; Buettner, Christoph] Mt Sinai Sch Med, Dept Med & Neurosci, New York, NY 10029 USA.
C3 Icahn School of Medicine at Mount Sinai
RP Buettner, C (corresponding author), Mt Sinai Sch Med, Dept Med & Neurosci, 1 Gustave L Levy Pl,POB 1055, New York, NY 10029 USA.
EM christoph.buettner@mssm.edu
RI Buettner, Christoph/F-5793-2013
OI Scherer, Thomas/0000-0003-4980-706X
FU National Institutes of Health [DK074873]; European Foundation for the
   Study of Diabetes; American Diabetes Association
FX This work was supported by DK074873 to CB from the National Institutes
   of Health and a European Foundation for the Study of Diabetes grant to
   TS. We thank George Kunos for critically reading the manuscript. CB is
   the recipient of a Junior Faculty Award from the American Diabetes
   Association.
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NR 43
TC 24
Z9 26
U1 0
U2 0
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0946-2716
EI 1432-1440
J9 J MOL MED
JI J. Mol. Med.
PD JUL
PY 2009
VL 87
IS 7
BP 663
EP 668
DI 10.1007/s00109-009-0459-y
PG 6
WC Genetics & Heredity; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Genetics & Heredity; Research & Experimental Medicine
GA 462HH
UT WOS:000267341200002
PM 19290485
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Sisson, SB
   Gibson, AE
   Short, K
   Gardner, AW
   Whited, T
   Robledo, C
   Thompson, DM
AF Sisson, Susan B.
   Gibson, Ashley E.
   Short, Kevin
   Gardner, Andrew W.
   Whited, Teresa
   Robledo, Candace
   Thompson, David M.
TI Light Activity Following a Meal and Postprandial Cardiometabolic Risk in
   Adolescents
SO PEDIATRIC EXERCISE SCIENCE
LA English
DT Article
ID ENDOTHELIAL FUNCTION; TRIACYLGLYCEROL CONCENTRATIONS;
   CARDIOVASCULAR-DISEASE; OXIDATIVE STRESS; PUBERTAL CHANGES;
   NORMAL-WEIGHT; SITTING TIME; EXERCISE; FAT; SEDENTARY
AB The purpose of this study was to determine if light physical activity (LPA) minimizes the impairment of cardiometabolic risk factors following a typical meal in adolescents. Eighteen adolescents (50% male, 14.8 +/- 2.3 yrs) consumed a meal (32% fat, 14% protein, 53% carbohydrate), then completed a walking (1.5mph for 45 min of each hour) or sitting treatment for 3 hr in randomized order on separate days. Following the meal, HDL cholesterol declined 4.8% but remained higher during walking at 3 hr (42.1mg/dl +/- 9.3) than sitting (8.4% decline; 40.5mg/dL +/- 9.9; treatment x time interaction, p < .03). The 3-hr insulin was lower after walking (24.8 mu IU/ml +/- 33.4) than sitting (37.8 mu IU/ml +/- 34.7; treatment x time interaction, p < .0001). Triglycerides increased by similar to 40% above baseline at 1 and 2 hr, with higher values for walking (treatment x time interaction, p < .02). However by 3 hr, triglycerides were not different from baseline. Area under the curve (AUC) analyses were not significantly different between treatments for any outcomes. Although minor, LPA appears to mitigate the undesirable postprandial changes in HDL cholesterol and insulin but not triglycerides, following a typical meal in adolescents.
C1 [Sisson, Susan B.; Gibson, Ashley E.; Short, Kevin; Gardner, Andrew W.; Whited, Teresa; Robledo, Candace; Thompson, David M.] Univ Oklahoma, Hlth Sci Ctr, Oklahoma City, OK USA.
C3 University of Oklahoma System; University of Oklahoma Health Sciences
   Center
RP Sisson, SB (corresponding author), Univ Oklahoma, Hlth Sci Ctr, Oklahoma City, OK USA.
RI Short, Kevin/AAC-2553-2020
OI Short, Kevin/0000-0001-6704-9587
FU University of Oklahoma Health Sciences Center Vice President of Research
   Seed Grant Program; University of Oklahoma Health Sciences Center
   General Clinical Research Center; National Center for Research
   Resources, National Institutes of Health [M01 RR14467]
FX This project was supported by the University of Oklahoma Health Sciences
   Center Vice President of Research Seed Grant Program awarded to Dr.
   Sisson. This project was partially supported by the University of
   Oklahoma Health Sciences Center General Clinical Research Center and by
   grant M01 RR14467 from the National Center for Research Resources,
   National Institutes of Health. We thank all the participants for
   volunteering their time in the completion of this study. We thank
   Elizabeth S. Ramey, MS, RD, who was integral in the coordination of
   study participations and data collection.
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NR 40
TC 8
Z9 9
U1 0
U2 7
PU HUMAN KINETICS PUBL INC
PI CHAMPAIGN
PA 1607 N MARKET ST, PO BOX 5076, CHAMPAIGN, IL 61820-2200 USA
SN 0899-8493
EI 1543-2920
J9 PEDIATR EXERC SCI
JI Pediatr. Exerc. Sci.
PD AUG
PY 2013
VL 25
IS 3
BP 347
EP 359
DI 10.1123/pes.25.3.347
PG 13
WC Pediatrics; Physiology; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics; Physiology; Sport Sciences
GA 218RA
UT WOS:000324448900004
PM 23501926
DA 2025-06-11
ER

PT J
AU Christopoulou, FD
   Kiortsis, DN
AF Christopoulou, F. D.
   Kiortsis, D. N.
TI An overview of the metabolic effects of rimonabant in randomized
   controlled trials: potential for other cannabinoid 1 receptor blockers
   in obesity
SO JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS
LA English
DT Review
DE diabetes; dyslipidaemia; endocannabinoid system; metabolic effects;
   obesity; rimonabant
ID CARDIOMETABOLIC RISK-FACTORS; ENERGY-BALANCE; CARDIOVASCULAR-DISEASE;
   OVERWEIGHT PATIENTS; ABDOMINAL OBESITY; RIO-EUROPE; WEIGHT;
   DYSLIPIDEMIA; LEPTIN; METAANALYSIS
AB P>What is known and objective:
   Rimonabant, a cannabinoid receptor blocker, has recently been used in clinical practice for weight loss and weight maintenance. Our aim was to review the results of trials of the drug in relation to weight loss and maintenance, and its impact on cardio-metabolic risk factors.
   Methods:
   Randomized controlled trials with rimonabant were selected, through a Medline search, using the terms: rimonabant, endocannabinoid antagonist and obesity. Reports of studies on large numbers of patients and covering the topics related to this review were included.
   Results and Discussion:
   In all the trials, there was a considerable reduction in body weight in subjects taking 20 mg rimonabant daily varying from 2 center dot 6 to 6 center dot 3 kg (placebo-subtracted changes). Rimonabant was also associated with haemoglobin A(1c) (HbA(1c)) reduction. In the Rimonabant in obesity (RIO)-diabetes study, diabetic patients taking metformin or sulphonylureas showed decrease in HbA(1c) levels by 0 center dot 5-0 center dot 6 +/- 0 center dot 8% when rimonabant was added, whereas in the Serenade trial patients with untreated diabetes showed a reduction in HbA(1c) of 0 center dot 8% vs. 0 center dot 3% with placebo. Similar results were obtained in diabetic patients under insulin treatment. The lipidaemic profile also improved in patients taking rimonabant 20 mg daily; levels of high density lipoprotein cholesterol (HDL-c) increased significantly while levels of triglycerides (TRG) decreased in all trials, and positive effects were also observed in patients with atherogenic or untreated dyslipidaemia. In all the RIO studies, prevalence of the metabolic syndrome decreased significantly.
   In addition, patients treated with 20 mg rimonabant daily exhibited increase in adiponectin. The metabolic changes observed were partly independent of the weight loss and could be attributed to independent peripheral effect of rimonabant. All these beneficial metabolic effects of rimonabant could lead to progress in the prevention of cardiovascular disease.
   However, in all the trials the incidence of adverse events leading to discontinuation was greater in the rimonabant treated patients than placebo, mainly because of psychiatric disorders (depression and anxiety), nausea and dizziness.
   What is new and Conclusion:
   Rimonabant is effective in reducing weight in the obese but may lead to intolerable adverse effects most notably psychiatric effects, which make it unsuitable for routine use. However, the drug provides useful proof of principle for this approach to weight loss. Novel cannabinoid type 1 receptor blockers with selectivity for peripheral receptors, may achieve similar metabolic results with decreased prevalence of psychiatric adverse effects.
C1 [Christopoulou, F. D.; Kiortsis, D. N.] Univ Ioannina, Sch Med, Physiol Lab, GR-45110 Ioannina, Greece.
C3 University of Ioannina
RP Kiortsis, DN (corresponding author), Univ Ioannina, Sch Med, Physiol Lab, GR-45110 Ioannina, Greece.
EM dkiorts@cc.uoi.gr
OI CHRISTOPOULOU, FOTEINI/0000-0003-3626-3753
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NR 29
TC 86
Z9 94
U1 0
U2 9
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0269-4727
EI 1365-2710
J9 J CLIN PHARM THER
JI J. Clin. Pharm. Ther.
PD FEB
PY 2011
VL 36
IS 1
BP 10
EP 18
DI 10.1111/j.1365-2710.2010.01164.x
PG 9
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 702FD
UT WOS:000285879100002
PM 21198716
OA gold
DA 2025-06-11
ER

PT J
AU Touati, S
   Meziri, F
   Devaux, S
   Berthelot, A
   Touyz, RM
   Laurant, P
AF Touati, Sabeur
   Meziri, Faycal
   Devaux, Sylvie
   Berthelot, Alain
   Touyz, Rhian M.
   Laurant, Pascal
TI Exercise Reverses Metabolic Syndrome in High-Fat Diet-Induced Obese Rats
SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
LA English
DT Article
DE ENDOTHELIUM; VESSEL; INSULIN; HYPERTENSION; Akt/eNOS PATHWAY
ID ENDOTHELIAL DYSFUNCTION; INSULIN-RESISTANCE; PHYSICAL-ACTIVITY;
   NITRIC-OXIDE; WEIGHT-LOSS; REDUCTION; RISK; MEN; HYPERTENSION;
   OVERWEIGHT
AB TOUATI, S., F. MEZIRI, S. DEVAUX, A. BERTHELOT, R. M. TOUYZ, and P. LAURANT. Exercise Reverses Metabolic Syndrome in High-Fat Diet-Induced Obese Rats. Med. Sci. Sports Exerc., Vol. 43, No. 3, pp. 398-407, 2011. Purpose: Chronic consumption of a high-fat diet induces obesity. We investigated whether exercise would reverse the cardiometabolic disorders associated with obesity without it being necessary to change from a high-to normal-fat diet. Methods: Sprague-Dawley rats were placed on a high-fat (HFD) or control diet (CD) for 12 wk. HFD rats were then divided into four groups: sedentary HFD (HFD-S), exercise trained (motor treadmill for 12 wk) HFD (HFD-Ex), modified diet (HFD to CD; HF/CD-S), and exercise trained with modified diet (HF/CD-Ex). Cardiovascular risk parameters associated with metabolic syndrome were measured, and contents of aortic Akt, phospho-Akt at Ser (473), total endothelial nitric oxide synthase (eNOS), and phospho-eNOS at Ser (1177) were determined by Western blotting. Results: Chronic consumption of HFD induced a metabolic syndrome. Exercise and dietary modifications reduced adiposity, improved glucose and insulin levels and plasma lipid profile, and exerted an antihypertensive effect. Exercise was more effective than dietary modification in improving plasma levels of thiobarbituric acid-reacting substance and in correcting the endothelium-dependent relaxation to acetylcholine and insulin. Furthermore, independent of the diet used, exercise increased Akt and eNOS phosphorylation. Conclusions: Metabolic syndrome induced by HFD is reversed by exercise and diet modification. It is demonstrated that exercise training induces these beneficial effects without the requirement for dietary modification, and these beneficial effects may be mediated by shear stress-induced Akt/eNOS pathway activation. Thus, exercise may be an effective strategy to reverse almost all the atherosclerotic risk factors linked to obesity, particularly in the vasculature.
C1 [Touati, Sabeur; Meziri, Faycal; Laurant, Pascal] UFR Sci, Avignon, France.
   [Touati, Sabeur; Meziri, Faycal; Touyz, Rhian M.] Univ Ottawa, Ottawa Hlth Res Inst, Kidney Res Ctr, Ottawa, ON, Canada.
   [Berthelot, Alain] Univ Franche Comte, F-25030 Besancon, France.
C3 University of Ottawa; Ottawa Hospital Research Institute; Universite de
   Franche-Comte
RP Touati, S (corresponding author), Pole Sportif & Rech Univ, Physiol & Physiopathol Adapat Cardiovasc & Exerci, 15 Blvd Limbert, F-84000 Avignon, France.
EM sabeur.touati@univ-avignon.fr
RI Touyz, Rhian/AAM-3564-2020
OI Touyz, Rhian/0000-0003-0670-0887; DEVAUX, Sylvie/0000-0003-4206-7580
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NR 40
TC 61
Z9 72
U1 0
U2 10
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0195-9131
EI 1530-0315
J9 MED SCI SPORT EXER
JI Med. Sci. Sports Exerc.
PD MAR
PY 2011
VL 43
IS 3
BP 398
EP 407
DI 10.1249/MSS.0b013e3181eeb12d
PG 10
WC Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Sport Sciences
GA 722OL
UT WOS:000287443200004
PM 20631645
OA Bronze
DA 2025-06-11
ER

PT J
AU Benyoub, N
   Merzouk, H
   Merzouk, AS
   Ghorzi, H
AF Benyoub, Noreddine
   Merzouk, Hafida
   Merzouk, Amel Saidi
   Ghorzi, Hafeda
TI Changes in metabolic parameters in growing male rats exposed to 10% and
   30% sucrose drinking
SO NUTRITION CLINIQUE ET METABOLISME
LA English
DT Article
DE Adipose tissue; Lipases; Liver; Obesity; Oxidative stress; Rat; Sucrose
   drink
ID SWEETENED BEVERAGE CONSUMPTION; HEPATIC TRIGLYCERIDE LIPASE; TISSUE
   LIPOPROTEIN-LIPASE; AGE-RELATED-CHANGES; OXIDATIVE STRESS; CHILDHOOD
   OBESITY; ADIPOSE-TISSUE; SUGAR; YOUNG; DIETARY
AB Sucrose drink induced obesity and metabolic syndrome in human and animal models. However, age specific metabolic effects of sucrose beverages are not clear yet. The purpose of this study was then to investigate changes in plasma biochemical parameters, oxidative stress markers, as well as lipid and redox contents and lipolytic activities in insulin target organs (liver, adipose tissue) in sucrose drinking rats at 10% and 30% during one month (day 30) and three months (day 90). Our results emphasized that sucrose drink induced obesity, adipose tissue accumulation with hyperinsulinemia, hyperglycemia, hyperlipidemia, liver steatosis, alterations in lipases activities and oxidative stress. These metabolic alterations were worsened by the amount of sucrose in the drink (30% versus 10%). The changes were apparent in young rats at day 30 and persisted until adulthood at day 90. Adult rats presented more sucrose-induced metabolic abnormalities. In conclusion, sucrose drink induced an early increase in metabolic syndrome components. These data indicate the need of corrective nutritional intervention for young people and also for adults. (C) 2021 Societe francophone nutrition clinique et metabolisme (SFNCM). Published by Elsevier Masson SAS. All rights reserved.
C1 [Benyoub, Noreddine; Merzouk, Hafida; Merzouk, Amel Saidi; Ghorzi, Hafeda] Univ Abou Bekr Belkaid Tlemcen, Fac Nat & Life Sci Earth & Universe, Dept Biol, Lab Physiol Physiopathol & Biochem Nutr, Tilimsen 13000, Algeria.
C3 Universite Abou Bekr Belkaid
RP Merzouk, H (corresponding author), Univ Abou Bekr Belkaid Tlemcen, Fac Nat & Life Sci Earth & Universe, Dept Biol, Lab Physiol Physiopathol & Biochem Nutr, Tilimsen 13000, Algeria.
EM hatidamerzouk_2@hotmail.com
OI merzouk, hafida/0000-0001-5081-3358
FU National Ministry of Higher Education and Scientific Research
FX The present study was done with the financial support of theNational
   Ministry of Higher Education and Scientific Research.
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NR 61
TC 0
Z9 0
U1 0
U2 2
PU MASSON EDITEUR
PI MOULINEAUX CEDEX 9
PA 21 STREET CAMILLE DESMOULINS, ISSY, 92789 MOULINEAUX CEDEX 9, FRANCE
SN 0985-0562
EI 1768-3092
J9 NUTR CLIN METAB
JI Nutr. Clin. Metab.
PD MAY
PY 2021
VL 35
IS 2
BP 129
EP 136
DI 10.1016/j.nupar.2020.11.002
PG 8
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA SK9JP
UT WOS:000656535300005
DA 2025-06-11
ER

PT J
AU Zacarias, AC
   Barbosa, MA
   Guerra-Sá, R
   De Castro, UGM
   Bezerra, FS
   de Lima, WG
   Cardoso, LM
   dos Santos, RAS
   Campagnole-Santos, MJ
   Alzamora, AC
AF Zacarias, Aline Cruz
   Barbosa, Maria Andrea
   Guerra-Sa, Renata
   Mendes De Castro, Uberdan Guilherme
   Bezerra, Frank Silva
   de Lima, Wanderson Geraldo
   Cardoso, Leonardo M.
   Souza dos Santos, Robson Augusto
   Campagnole-Santos, Maria Jose
   Alzamora, Andreia Carvalho
TI Swimming training induces liver adaptations to oxidative stress and
   insulin sensitivity in rats submitted to high-fat diet
SO REDOX REPORT
LA English
DT Article
DE Physical training; oxidative stress; insulin signaling pathway; high-fat
   diet; liver
ID METABOLIC SYNDROME; PHYSICAL-ACTIVITY; GENE-EXPRESSION; ADIPOSE-TISSUE;
   EXERCISE; ANTIOXIDANT; RESISTANCE; CATALASE; DEFENSE
AB Oxidative stress, physical inactivity and high-fat (FAT) diets are associated with hepatic disorders such as metabolic syndrome (MS). The therapeutic effects of physical training (PT) were evaluated in rats with MS induced by FAT diet for 13 weeks, on oxidative stress and insulin signaling in the liver, during the last 6 weeks. FAT-sedentary (SED) rats increased body mass, retroperitoneal fat, mean arterial pressure (MAP) and heart rate (HR), and total cholesterol, serum alanine aminotransferase, glucose and insulin. Livers of FAT-SED rats increased superoxide dismutase activity, thiobarbituric acid-reactive substances, protein carbonyl and oxidized glutathione (GSSG); and decreased catalase activity, reduced glutathione/GSSG ratio, and the mRNA expression of insulin receptor substrate 1 (IRS-1) and serine/threonine kinase 2. FAT-PT rats improved in fitness and reduced their body mass, retroperitoneal fat, and glucose, insulin, total cholesterol, MAP and HR; and their livers increased superoxide dismutase and catalase activities, the reduced glutathione/GSSG ratio and the expression of peroxisome proliferator-activated receptor gamma and insulin receptor compared to FAT-SED rats. These findings indicated adaptive responses to PT by restoring the oxidative balance and insulin signaling in the liver and certain biometric and biochemical parameters as well as MAP in MS rats.
C1 [Guerra-Sa, Renata; Bezerra, Frank Silva; de Lima, Wanderson Geraldo; Cardoso, Leonardo M.; Alzamora, Andreia Carvalho] Univ Fed Ouro Preto, Inst Ciencias Exatas & Biol, Dept Ciencias Biol, Ouro Preto, MG, Brazil.
   [Zacarias, Aline Cruz; Barbosa, Maria Andrea; Guerra-Sa, Renata; Mendes De Castro, Uberdan Guilherme; Bezerra, Frank Silva; de Lima, Wanderson Geraldo; Cardoso, Leonardo M.; Alzamora, Andreia Carvalho] Univ Fed Ouro Preto, Nucleo Pesquisa Ciencias Biol, Ouro Preto, MG, Brazil.
   [Barbosa, Maria Andrea; Alzamora, Andreia Carvalho] Univ Fed Ouro Preto, Programa Posgrad Saude & Nutr, Ouro Preto, MG, Brazil.
   [Souza dos Santos, Robson Augusto; Campagnole-Santos, Maria Jose] Univ Fed Minas Gerais, Inst Ciencias Biol, Dept Fisiol & Biofis, Belo Horizonte, MG, Brazil.
C3 Universidade Federal de Ouro Preto; Universidade Federal de Ouro Preto;
   Universidade Federal de Ouro Preto; Universidade Federal de Minas Gerais
RP Alzamora, AC (corresponding author), Univ Fed Ouro Preto, Dept Ciencias Biol, Morro Cruzeiro 35, BR-400000 Ouro Preto, MG, Brazil.
EM andreiaalzamora@iceb.ufop.br
RI Santos, Robson/C-9336-2011; Campagnole-Santos, Maria/AAK-7515-2020;
   Cardoso, Leonardo/AAF-6516-2019; Bezerra, Frank/AAD-1233-2019; Lima,
   Wanderson/Y-7198-2019; Campagnole-Santos, Maria/F-5590-2017
OI Bezerra, Frank/0000-0002-0804-5196; Cardoso,
   Leonardo/0000-0001-9821-0484; Zacarias, Aline Cruz/0000-0002-2574-1775;
   Campagnole-Santos, Maria/0000-0001-9483-4206; Santos,
   Robson/0000-0001-8738-5852; Lima, Wanderson/0000-0001-9844-3472
FU Universidade Federal de Ouro Preto (UFOP); Pro-Reitoria de Pos-Graduacao
   (PROPP-UFOP); FAPEMIG (Fundacao de Amparo a Pesquisa do Estado de Minas
   Gerais)-Rede Toxifar [APQ-3384-3.13/07]; CNPq (Conselho Nacional de
   Desenvolvimento Cientifico e Tecnologico) [Universal472497/2013-8];
   FAPEMIG-Universal and Pronex Project Grant (FAPEMIG/CNPq)
FX This study was supported by the Universidade Federal de Ouro Preto
   (UFOP), Pro-Reitoria de Pos-Graduacao (PROPP-UFOP), FAPEMIG (Fundacao de
   Amparo a Pesquisa do Estado de Minas Gerais)-Rede Toxifar, CNPq
   (Conselho Nacional de Desenvolvimento Cientifico e Tecnologico),
   FAPEMIG-Universal and Pronex Project Grant (FAPEMIG/CNPq). Aline Cruz
   Zacarias is a Master's Degree student in the Programa de Pos-graduacao
   Ciencias Biologicas, NUPEB, UFOP; CNPq: [Grant Number
   Universal472497/2013-8]; FAPEMIG: [Grant Number APQ-3384-3.13/07].
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NR 47
TC 13
Z9 14
U1 0
U2 1
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1351-0002
EI 1743-2928
J9 REDOX REP
JI Redox Rep.
PY 2017
VL 22
IS 6
BP 515
EP 523
DI 10.1080/13510002.2017.1315513
PG 9
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA FL2KP
UT WOS:000414044500035
PM 28403686
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Casagrande, BP
   Estadella, D
AF Casagrande, Breno P.
   Estadella, Debora
TI Withdrawing from obesogenic diets: benefits and barriers in the short-
   and long-term in rodent models
SO AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
LA English
DT Review
DE behavior; metabolism; review; reward system; stress hormones
ID HIGH-FAT DIET; DEPRESSIVE-LIKE BEHAVIOR; ANXIETY-LIKE BEHAVIOR;
   METABOLIC SYNDROME; HIGH-CARBOHYDRATE; GENE-EXPRESSION; CAFETERIA DIET;
   GUT MICROBIOTA; PALATABLE DIET; EXPOSURE
AB There is accumulating evidence of dietary impact on several metabolic parameters. Unhealthy diets are estimated to be responsible for about 20% of the deaths worldwide. The recommendation is to improve the dietary pattern, aiming to prevent further harm. In this context. we reviewed the benefits and barriers of withdrawing from continuous obesogenic diet intake in the short- and long-term, which were found in rodent models. Although dietary modifications demand a re-establishment of the equilibrium, withdrawing was seen as a homeostatic insult and thus elicited several responses to protect the organism. In the short-term, withdrawal presented stressful and reward destimulating responses. The intake of obesogenic diets presented rewarding and stress destimulating responses. Whereas withdrawing in the long term ameliorated several biological functions and histopathologic features, it was not effective at reestablishing food intake and normalizing feeding behaviors or reward pathways. Altogether, terminating obesogenic diet intake does not immediately extinguish all negative consequences, and it even elicits brain behavioral and metabolic modifications. These modifications can hinder the maintenance of habits' change and prevent reaching the long-term benefits of diet improvement.
C1 [Casagrande, Breno P.; Estadella, Debora] Univ Fed Sao Paulo, Inst Hlth & Soc, Biosci Dept, Santos, SP, Brazil.
C3 Universidade Federal de Sao Paulo (UNIFESP)
RP Estadella, D (corresponding author), Univ Fed Sao Paulo, Inst Hlth & Soc, Biosci Dept, Santos, SP, Brazil.
EM estadella.debora@gmail.com
RI Casagrande, Breno/Y-1442-2019; Estadella, Debora/G-5817-2012
OI Estadella, Debora/0000-0001-9853-3662; Picin Casagrande,
   Breno/0000-0001-9478-8262
FU "Sao Paulo Research Foundation" (FAPESP) [17/25420-3]; "Coordination for
   the Improvement of Higher Education Personnel" (CAPES Brazil) [001];
   Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
   [17/25420-3] Funding Source: FAPESP
FX This work was supported by "Coordination for the Improvement of Higher
   Education Personnel" (CAPES Brazil - Financial Code 001); and the "Sao
   Paulo Research Foundation" (FAPESP) under Grant no. 17/25420-3.
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NR 47
TC 7
Z9 7
U1 0
U2 2
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0193-1849
EI 1522-1555
J9 AM J PHYSIOL-ENDOC M
JI Am. J. Physiol.-Endocrinol. Metab.
PD SEP
PY 2020
VL 319
IS 3
BP E485
EP E493
DI 10.1152/ajpendo.00174.2020
PG 9
WC Endocrinology & Metabolism; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Physiology
GA NS6KW
UT WOS:000572368900003
PM 32663098
DA 2025-06-11
ER

PT J
AU Prasatthong, P
   Meephat, S
   Rattanakanokchai, S
   Bunbupha, S
   Prachaney, P
   Maneesai, P
   Pakdeechote, P
AF Prasatthong, Patoomporn
   Meephat, Sariya
   Rattanakanokchai, Siwayu
   Bunbupha, Sarawoot
   Prachaney, Parichat
   Maneesai, Putcharawipa
   Pakdeechote, Poungrat
TI Hesperidin ameliorates signs of the metabolic syndrome and cardiac
   dysfunction via IRS/Akt/GLUT4 signaling pathway in a rat model of
   diet-induced metabolic syndrome
SO EUROPEAN JOURNAL OF NUTRITION
LA English
DT Article
DE Hesperidin; Cardiac function; Cardiac insulin signaling pathway; p-IRS1;
   GLUT4; Metabolic syndrome
ID HIGH-FAT-DIET; INSULIN-RESISTANCE; GLUCOSYL HESPERIDIN; OXIDATIVE
   STRESS; MOUSE MODEL; METFORMIN; PRESSURE; ISCHEMIA; OBESITY; LIVER
AB Background Hesperidin has been reported to have biological activities such as antihypertensive, hypoglycemic, and antioxidant effects. This study investigated whether hesperidin could improve signs of the metabolic syndrome and cardiac function in a high-fat diet (HFD) induced metabolic syndrome (MS) in rats. Methods Male Sprague-Dawley rats were fed HFD and 15% fructose for 16 weeks and treated with hesperidin (15 or 30 mg/kg, based on signs of MS from a preliminary study) or metformin, a positive control agent, (100 mg/kg) for the final four weeks. Cardiac function, blood pressure, fasting blood glucose, oral glucose tolerance, serum insulin, and lipid profiles were measured. Histomorphometrics of left ventricles, epidydimal fat pads and liver were evaluated. Expressions of phosphorylate insulin receptor substrate1(p-IRS1), p-Akt and GLUT4 in cardiac tissue were determined. Results Hesperidin and metformin attenuated MS in HFD rats (p < 0.05). The accumulation of visceral fat pads and fatty liver associated with increases in liver lipid contents and liver enzymes were found in MS rats that were alleviated in hesperidin or metformin-treated groups (p < 0.05). Hesperidin and metformin improved cardiac dysfunction and hypertrophy observed in MS rats (p < 0.05). Restoration of the insulin signaling pathway, IRS/Akt/GLUT4 protein expression, was demonstrated in hesperidin and metformin-treated groups (p < 0.05). Hesperidin (30 mg/kg) was more effective than the lower dose. Conclusion Hesperidin was effective in reducing signs of MS and alterations of LV hypertrophy and function. These beneficial effects on the heart were associated with the restoration of the cardiac insulin signaling pathway in MS rats.
C1 [Prasatthong, Patoomporn; Meephat, Sariya; Maneesai, Putcharawipa; Pakdeechote, Poungrat] Khon Kaen Univ, Fac Med, Dept Physiol, Khon Kaen 40002, Thailand.
   [Rattanakanokchai, Siwayu] Khon Kaen Univ, Fac Vet Med, Khon Kaen 40002, Thailand.
   [Bunbupha, Sarawoot] Mahasarakham Univ, Fac Med, Maha Sarakham 44000, Thailand.
   [Prachaney, Parichat] Khon Kaen Univ, Fac Med, Dept Anat, Khon Kaen 40002, Thailand.
C3 Khon Kaen University; Khon Kaen University; Mahasarakham University;
   Khon Kaen University
RP Pakdeechote, P (corresponding author), Khon Kaen Univ, Fac Med, Dept Physiol, Khon Kaen 40002, Thailand.
EM ppoung@kku.ac.th
RI Maneesai, Putcharawipa/AAK-4258-2021
FU Graduate School, Invitation Research Fund [IN63119]; Cardiovascular
   Research Group, Khon Kaen University, Khon Kaen, Thailand;  [611JH216]
FX This study is financially supported by the Scholarship for Supporting
   Lecturer to Admit High Potential Student to Study and Research' on his
   expert program Year 2017 (Research No. 611JH216), Graduate School,
   Invitation Research Fund (IN63119) and Cardiovascular Research Group,
   Khon Kaen University, Khon Kaen, Thailand. We would like to acknowledge
   Prof. James A. Will, for editing the MS via Publication Clinic KKU,
   Thailand.
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NR 60
TC 24
Z9 29
U1 1
U2 13
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1436-6207
EI 1436-6215
J9 EUR J NUTR
JI Eur. J. Nutr.
PD MAR
PY 2021
VL 60
IS 2
BP 833
EP 848
DI 10.1007/s00394-020-02291-4
EA MAY 2020
PG 16
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA QK8PU
UT WOS:000553644900001
PM 32462317
DA 2025-06-11
ER

PT J
AU Escudero-López, B
   Fernández-Pachón, MS
   Herrero-Martín, G
   Ortega, A
   Cerrillo, I
   Martín, F
   Berná, G
AF Escudero-Lopez, B.
   Fernandez-Pachon, M. S.
   Herrero-Martin, G.
   Ortega, A.
   Cerrillo, I.
   Martin, F.
   Berna, G.
TI Orange beverage ameliorates high-fat-diet-induced metabolic disorder in
   mice
SO JOURNAL OF FUNCTIONAL FOODS
LA English
DT Article
DE Fermented orange juice; Bioactive compounds; HFD; Metabolic syndrome;
   Antioxidant status; Lipid profile
ID ALCOHOLIC FERMENTATION; ANTIOXIDANT ACTIVITY; INFLAMMATORY MARKERS;
   OXIDATIVE STRESS; JUICE INTAKE; WEIGHT-GAIN; URIC-ACID; RED WINE;
   CONSUMPTION; LIVER
AB Metabolic syndrome (MetS) refers to a group of disorders that includes insulin resistance, central obesity, arterial hypertension and hyperlipidaemia. Regular consumption of bioactive compounds has consistently been associated with a reduced risk of these disorders. The aim of this study was to determine if an orange beverage with high concentrations of bioactive compounds (flavanones, carotenoids, melatonin, and ascorbic acid) and low alcohol content (<1%, v/v) improves metabolic parameters through modulation of oxidative stress, lipid profile and inflammatory response in a rodent model of high fat diet (HFD)-induced obesity. Mice with HFD-induced MetS were fed the orange beverage for 12 weeks (volume equivalent to 250 mL/day in human). Long-term intake of the orange beverage decreased plasma TAG, oxidized LDL and C-reactive protein levels. The present data provide evidence of a beneficial effect of orange beverage intake on some outcome parameters related to HFD-induced MetS. (c) 2016 Elsevier Ltd. All rights reserved.
C1 [Escudero-Lopez, B.; Fernandez-Pachon, M. S.; Herrero-Martin, G.; Ortega, A.; Cerrillo, I.; Martin, F.; Berna, G.] Univ Pablo Olavide, Dept Mol Biol & Biochem Engn, Area Nutr & Food Sci, ES-41013 Seville, Spain.
   [Fernandez-Pachon, M. S.; Cerrillo, I.] Univ Autonoma Chile, Fac Ciencias Salud, Av Pedro Valdivia 641, Santiago, Chile.
   [Ortega, A.; Martin, F.; Berna, G.] CIBERDEM Inst Salud Carlos III, CIBER Diabet Enfermedades Metabol Asociadas, Madrid 28029, Spain.
C3 Universidad Pablo de Olavide; Universidad Autonoma de Chile; CIBER -
   Centro de Investigacion Biomedica en Red; CIBERDEM
RP Berná, G (corresponding author), Univ Pablo Olavide, Genoveva Berna Amoros, Dept Biol Mol & Ingn Bioquim, Carretera Utrera Km 1, Seville 41013, Spain.
EM gberamo@upo.es
RI Fernández-Pachón, María-Soledad/GOE-5442-2022; Berna,
   Genoveva/AAG-7849-2020; Ortega, Angeles/ABA-8118-2020; Berna,
   Genoveva/K-4562-2014; Martin, Franz/K-4197-2014; Cerrillo Garcia,
   Isabel/K-1455-2016; Escudero-Lopez, Blanca/ABG-3957-2020
OI Berna, Genoveva/0000-0001-8185-8428; Fernandez-Pachon,
   Maria-Soledad/0000-0002-9524-298X; Martin, Franz/0000-0002-5745-8704;
   Ortega de la Torre, Maria de los Angeles/0000-0002-0503-5793; Cerrillo
   Garcia, Isabel/0000-0001-9068-8176; Escudero-Lopez,
   Blanca/0000-0002-4964-1306; Herrero Martin, Griselda/0000-0002-1120-8822
FU Junta de Andalucia; Ministerio de Ciencia e Innovacion [P09-AGR4814M,
   IPT-20111008]
FX We are grateful to Grupo Hesperides Biotech S.L. for providing samples
   of fermented orange juice. Authors are grateful for the support of the
   "Junta de Andalucia" and "Ministerio de Ciencia e Innovacion" through
   the Projects P09-AGR4814M and IPT-20111008 respectively. The Research
   Project grant of BEL is supported by the Junta de Andalucia. Authors
   belong to PAIDI Research Group BI0311 from Junta de Andalucia.
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NR 63
TC 8
Z9 9
U1 0
U2 30
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1756-4646
J9 J FUNCT FOODS
JI J. Funct. Food.
PD JUN
PY 2016
VL 24
BP 254
EP 263
DI 10.1016/j.jff.2016.04.013
PG 10
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA DP3BJ
UT WOS:000378367100025
DA 2025-06-11
ER

PT J
AU Calamita, G
   Portincasa, P
AF Calamita, Giuseppe
   Portincasa, Piero
TI Present and future therapeutic strategies in non-alcoholic fatty liver
   disease
SO EXPERT OPINION ON THERAPEUTIC TARGETS
LA English
DT Review
DE antioxidant; aquaglyceroporin; aquaporin; fatty liver; glitazone;
   insulin-resistance; liver steatosis; metabolic syndrome; oxidative
   stress; probiotic; sibutramine
ID RECEPTOR ANTAGONIST SR141716; PLACEBO-CONTROLLED TRIAL; ADIPOSE
   GENE-EXPRESSION; MORBIDLY OBESE-PATIENTS; ADENOSYL-L-METHIONINE;
   NECROSIS-FACTOR-ALPHA; VITAMIN-E TREATMENT; INSULIN-RESISTANCE;
   URSODEOXYCHOLIC ACID; HEPATIC STEATOSIS
AB Non-alcoholic fatty liver disease (NAFLD) is found in individuals who do not drink or abuse alcohol and represents a significant health burden for the general community. NAFLD is often associated with one or more features of the metabolic syndrome and has potential for evolution towards non-alcoholic steatohepatitis (NASH), the necro-inflammatory form of liver steatosis. The most worrisome evolutive events in a subgroup of NASH patients include advanced liver fibrosis, cirrhosis, and hepatocellular carcinoma. Pathophysiology of NAFLD/NASH is complex, but studies point to a pre-eminent role of oxidative stress and lipid peroxiclation in the liver, including early mitochondrial dysfunction. Changes follow an insulin resistance status with a background of a chronic pro-inflammatory status due to an excess of visceral adiposity. Although no established therapy exists for NAFLD/NASH, potential therapeutic approaches are discussed in this review.
C1 Univ Bari, Dept Gen & Environm Physiol, I-70121 Bari, Italy.
   Univ Bari, Clin Med A Murri, Dept Internal Med & Publ Med, I-70121 Bari, Italy.
C3 Universita degli Studi di Bari Aldo Moro; Universita degli Studi di Bari
   Aldo Moro
RP Portincasa, P (corresponding author), Univ Med Sch Bari, Clin Med A Murri, Dept Internal Med & Publ Med, Piazza Giulio Cesare 11, I-70124 Bari, Italy.
EM p.portincasa@semeiotica.uniba.it
RI portincasa, piero/J-7245-2018
OI Calamita, Giuseppe/0000-0003-4666-9546; portincasa,
   piero/0000-0001-5359-1471
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NR 235
TC 40
Z9 45
U1 1
U2 3
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1472-8222
EI 1744-7631
J9 EXPERT OPIN THER TAR
JI Expert Opin. Ther. Targets
PD SEP
PY 2007
VL 11
IS 9
BP 1231
EP 1249
DI 10.1517/14728222.11.9.1231
PG 19
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 216DC
UT WOS:000249857100009
PM 17845148
DA 2025-06-11
ER

PT J
AU Liu, WL
   Xu, YY
   Xiao, LL
   Li, K
   Liu, Q
AF Liu, Weili
   Xu, Yingying
   Xiao, Liling
   Li, Ke
   Liu, Qiang
TI Composite dietary antioxidant index is associated with the prevalence of
   metabolic syndrome in females: results from NHANES 2011-2016
SO FRONTIERS IN NUTRITION
LA English
DT Article
DE NHANES; metabolic syndrome; CDAI; estrogen; females
ID INSULIN-RESISTANCE; OXIDATIVE STRESS; RISK; CANCER; 17-BETA-ESTRADIOL;
   EXPRESSION; MENOPAUSE; ESTROGENS
AB Objective: This study sought to investigate the association between metabolic syndrome (MetS) and Composite Dietary Antioxidant Index (CDAI) in females, with the goal of informing evidence-based prevention and clinical management strategies for MetS. Methods: The 2011-2016 National Health and Nutrition Examination Survey (NHANES) recruited a total of 2,790 female participants and screened 1,562 participants for estrogen non-deficiency. The diagnosis of MetS was based on criteria set by the National Cholesterol Education Program-Adult Treatment Panel III. The CDAI was calculated according to the intake of 10 dietary antioxidants. Multivariable logistic regression was performed to investigate the relationship between the CDAI and MetS in females. We also performed restricted cubic splines, two-piecewise linear regression, and subgroup analysis in further analysis. Results: Our analyses demonstrated a significant inverse association between the Composite Dietary Antioxidant Index (CDAI) and metabolic syndrome (MetS) prevalence in females. Restricted cubic spline analysis indicated a linear dose-response relationship (p for linearity = 0.029), with two-piecewise linear regression analysis revealed an inflection point at 1.99. Below 1.99, each unit increase in the CDAI was associated with a 2% reduction in the risk of MetS in females; above 1.99, the risk reduction was 1%. Participants without MetS were significantly younger than those with MetS (43.49 +/- 16.04 vs. 54.77 +/- 15.52 years, p < 0.001). Notably, estrogen levels also were negatively correlated with the prevalence of MetS. Subgroup analysis revealed that the relationship between the CDAI and MetS remained consistent across all subgroups. Conclusion: In the female population, CDAI levels exhibited an inverse relationship with the prevalence of metabolic syndrome, and estrogen levels demonstrated a negative correlation with its incidence.
C1 [Liu, Weili; Xiao, Liling; Liu, Qiang] Shifang Peoples Hosp, Shifang, Peoples R China.
   [Xu, Yingying; Li, Ke] Univ Elect Sci & Technol China, Sch Life Sci & Technol, Chengdu, Peoples R China.
C3 University of Electronic Science & Technology of China
RP Liu, Q (corresponding author), Shifang Peoples Hosp, Shifang, Peoples R China.; Li, K (corresponding author), Univ Elect Sci & Technol China, Sch Life Sci & Technol, Chengdu, Peoples R China.
EM colinlike@163.com; sfsrmyykjk@163.com
FU Sichuan Provincial Science and Technology Achievement Transfer and
   Transformation Guidance Program [24ZHSF0072]; Sichuan Provincial Key
   Research and Development Program, Sichuan, China [25QYCX0359]
FX The author(s) declare that financial support was received for the
   research and/or publication of this article. This work was supported by
   2024 Sichuan Provincial Science and Technology Achievement Transfer and
   Transformation Guidance Program (No. 24ZHSF0072) and 2025 Sichuan
   Provincial Key Research and Development Program (No. 25QYCX0359),
   Sichuan, China.
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NR 62
TC 0
Z9 0
U1 3
U2 3
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD MAR 27
PY 2025
VL 12
AR 1529332
DI 10.3389/fnut.2025.1529332
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 1HX1Y
UT WOS:001465419800001
PM 40212720
OA gold
DA 2025-06-11
ER

PT J
AU Idres, YA
   Tousch, D
   Cazals, G
   Lebrun, A
   Naceri, S
   Bidel, LPR
   Poucheret, P
AF Idres, Yanis A.
   Tousch, Didier
   Cazals, Guillaume
   Lebrun, Aurelien
   Naceri, Sarah
   Bidel, Luc P. R.
   Poucheret, Patrick
TI A Novel Sesquiterpene Lactone Xanthatin-13-(pyrrolidine-2-carboxylic
   acid) Isolated from Burdock Leaf Up-Regulates Cells' Oxidative Stress
   Defense Pathway
SO ANTIOXIDANTS
LA English
DT Article
DE burdock leaf; sesquiterpene lactones; xanthonolide; oxidative stress;
   glucose-6-phosphodeshydrogenase; molecular docking
ID XANTHIUM-STRUMARIUM L.; CICHORIUM-INTYBUS L.; NF-KAPPA-B; CHICORIC ACID;
   DUAL ROLES; IN-VITRO; GLUCOSE-6-PHOSPHATE-DEHYDROGENASE; XANTHATIN;
   EXTRACT; EXPRESSION
AB The aim of our study was to identify novel molecules able to induce an adaptative response against oxidative stress during the first stages of metabolic syndrome. A cellular survival in vitro test against H2O2-based test was applied after pretreatment with various natural bitter Asteraceae extracts. This screening revealed potent protection from burdock leaf extract. Using chromatography and LC-MS-RMN, we then isolated and identified an original sesquiterpene lactone bioactive molecule: the Xanthatin-13-(pyrrolidine-2-carboxylic acid) (XPc). A real-time RT-qPCR experiment was carried out on three essential genes involved in oxidative stress protection: GPx, SOD, and G6PD. In presence of XPc, an over-expression of the G6PD gene was recorded, whereas no modification of the two others genes could be observed. A biochemical docking approach demonstrated that XPc had a high probability to directly interact with G6PD at different positions. One of the most probable docking sites corresponds precisely to the binding site of AG1, known to stabilize the G6PD dimeric form and enhance its activity. In conclusion, this novel sesquiterpene lactone XPc might be a promising prophylactic bioactive agent against oxidative stress and inflammation in chronic diseases such as metabolic syndrome or type 2 diabetes.</p>
C1 [Idres, Yanis A.; Tousch, Didier; Poucheret, Patrick] Univ Montpellier, SupAgro Montpellier, CIRAD, UMR Qualisud 95, 15 Ave Charles Flahault,BP 14491, F-34093 Montpellier 5, France.
   [Cazals, Guillaume; Lebrun, Aurelien] Univ Montpellier, Lab Mesure Phys, Pl Eugene Bataillon, F-34093 Montpellier 5, France.
   [Naceri, Sarah] Univ Paris, Lab Biol Fonct & Adaptat, CNRS, UMR 8251, 35 Rue Helene Br, F-75013 Paris, France.
   [Bidel, Luc P. R.] SupAgro, CIRAD, INRA, UMR AGAP, 2 Pl Pierre Viala, F-34060 Montpellier, France.
C3 CIRAD; Institut Agro; Montpellier SupAgro; Universite de Montpellier;
   Universite de Montpellier; Centre National de la Recherche Scientifique
   (CNRS); CNRS - National Institute for Biology (INSB); Universite Paris
   Cite; Universite de Montpellier; INRAE; Institut Agro; Montpellier
   SupAgro; CIRAD
RP Idres, YA; Tousch, D (corresponding author), Univ Montpellier, SupAgro Montpellier, CIRAD, UMR Qualisud 95, 15 Ave Charles Flahault,BP 14491, F-34093 Montpellier 5, France.
EM guillaume.cazals@umontpellier.fr; sarah.naceri@etu.u-paris.fr;
   luc.bidel@inrae.fr; patrick.poucheret@umontpellier.fr
RI Aurelien, LEBRUN/HXK-2092-2023; Didier, Tousch/HKM-7752-2023
OI Lebrun, Aurelien/0000-0002-0801-9684
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NR 61
TC 4
Z9 4
U1 1
U2 16
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD OCT
PY 2021
VL 10
IS 10
AR 1617
DI 10.3390/antiox10101617
PG 14
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA WQ6EF
UT WOS:000713906700001
PM 34679753
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Zhong, XM
   Ming, JX
   Li, CQ
AF Zhong, Xuemin
   Ming, Jinxuan
   Li, Changqing
TI Association between dyslipidemia and depression: a cross-sectional
   analysis of NHANES data from 2007 to 2018
SO BMC PSYCHIATRY
LA English
DT Article
DE Dyslipidemia; Depression; High-density Lipoprotein Cholesterol;
   Low-Density Lipoprotein Cholesterol; Triglycerides; Triglyceride glucose
   index
ID METABOLIC SYNDROME; SERUM-CHOLESTEROL; MAJOR DEPRESSION; BIPOLAR
   DISORDER; LIPID-LEVELS; SYMPTOMS; INCONTINENCE; METAANALYSIS; CORONARY;
   HISTORY
AB Background The relationship between depression and dyslipidemia remains controversial, with inconsistent findings across studies. This study aimed to investigate the association between blood lipid levels and depression using data from the National Health and Nutrition Examination Survey (NHANES) spanning from 2007 to 2018. Methods This cross-sectional study included 12,819 adult participants from NHANES. Depression was assessed using a nine-item depression screening instrument. Serum lipid levels, including total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG), were measured using Roche modular P and Roche Cobas 6000 chemistry analyzers. Survey-weighted multiple logistic regression was used to assess the relationships between serum lipid levels and depression. Results We observed a statistically significant negative association between HDL levels and depression (odds ratio [OR]: 0.72, 95% confidence interval [CI]: 0.58-0.90). After adjustments for covariates, HDL-C, TG, and the triglyceride glucose (TyG) index showed significant associations with depression (ORs: 0.66, 1.08, and 1.01, respectively). A linear correlation was observed between HDL-C levels and depression (P < 0.01), while TG levels and the TyG index exhibited nonlinear associations (p < 0.01 and p < 0.05, respectively). No significant positive associations were observed between increased TC or LDL-C levels and the risk of depression. Conclusions High HDL-C levels were negatively associated with depression, while TG levels and the TyG index were positively associated with depression. Clinical attention should be given to the detection of lipid levels in patients with depression.
C1 [Zhong, Xuemin; Li, Changqing] Chongqing Med Univ, Affiliated Hosp 2, Chongqing, Peoples R China.
   [Zhong, Xuemin] Second Peoples Hosp Chengdu, Chengdu, Peoples R China.
   [Ming, Jinxuan] Southwest Med Univ, Luzhou, Peoples R China.
C3 Chongqing Medical University; Southwest Medical University
RP Li, CQ (corresponding author), Chongqing Med Univ, Affiliated Hosp 2, Chongqing, Peoples R China.
EM licq@cqmu.edu.cn
RI zhong, xuemin/JFS-8578-2023
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NR 46
TC 3
Z9 3
U1 2
U2 2
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-244X
J9 BMC PSYCHIATRY
JI BMC Psychiatry
PD DEC 6
PY 2024
VL 24
IS 1
AR 893
DI 10.1186/s12888-024-06359-x
PG 8
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychiatry
GA O6K8E
UT WOS:001372199400001
PM 39643888
OA gold
DA 2025-06-11
ER

PT J
AU Sattari, M
   Amri, J
   Shahaboddin, ME
   Sattari, M
   Tabatabaei-Malazy, O
   Azmon, M
   Meshkani, R
   Panahi, G
AF Sattari, Mahboobe
   Amri, Jamal
   Shahaboddin, Mohammad Esmaeil
   Sattari, Mohadese
   Tabatabaei-Malazy, Ozra
   Azmon, Marzyeh
   Meshkani, Reza
   Panahi, Ghodratollah
TI The protective effects of fisetin in metabolic disorders: a focus on
   oxidative stress and associated events
SO JOURNAL OF DIABETES AND METABOLIC DISORDERS
LA English
DT Review
ID LIPID-ACCUMULATION; INSULIN-RESISTANCE; HYDROGEN-PEROXIDE; EMERGING
   ROLE; NRF2; APOPTOSIS; INJURY; DAMAGE; CELLS; INFLAMMATION
AB Metabolic syndrome is increasingly recognized as a significant precursor to various chronic diseases, contributing to a growing public health concern. Its complex pathogenesis involves multiple interrelated mechanisms, with oxidative stress identified as a cornerstone that exacerbates other pathogenic pathways. This study elucidates the molecular mechanisms by which oxidative stress intensifies metabolic disturbances, particularly insulin resistance. Some recent research has focused on fisetin, a natural product known for its potential benefits in diabetes and its associated microvascular and macrovascular complications. This paper compiles a comprehensive collection of findings by reviewing studies conducted over the past decade, detailing dosages, investigated markers, and their respective outcomes. Notably, a recurrent finding was fisetin's ability to enhance Nrf2, a principal regulator of antioxidant defense, in both metabolic and non-metabolic diseases. Furthermore, intriguing results suggest that the effects of Nrf2 extend beyond oxidative stress modulation, demonstrating favorable impacts on tissue-specific functions in metabolic regulation. This highlights fisetin not only as an antioxidant but also as a potential therapeutic agent for improving metabolic health and mitigating the effects of metabolic syndrome. In conclusion, fisetin can enhance the body's antioxidant defenses by modulating the Nrf2 pathway while also improving metabolic health through its effects on inflammation, cell survival, and energy metabolism, offering a comprehensive approach to managing metabolic disorders.
C1 [Sattari, Mahboobe; Amri, Jamal; Meshkani, Reza; Panahi, Ghodratollah] Univ Tehran Med Sci, Fac Med, Dept Clin Biochem, Tehran, Iran.
   [Sattari, Mahboobe; Amri, Jamal] Univ Tehran Med Sci, Students Sci Res Ctr SSRC, Tehran, Iran.
   [Shahaboddin, Mohammad Esmaeil] Kashan Univ Med Sci, Inst Basic Sci, Res Ctr Biochem & Nutr Metab Dis, Kashan, Iran.
   [Sattari, Mohadese] Kashan Univ Med Sci, Sch Med, Kashan, Iran.
   [Sattari, Mohadese] Kashan Univ Med Sci, Student Res Comm, Kashan, Iran.
   [Tabatabaei-Malazy, Ozra] Univ Tehran Med Sci, Endocrinol & Metab Populat Sci Inst, Noncommunicable Dis Res Ctr, Tehran, Iran.
   [Tabatabaei-Malazy, Ozra] Univ Tehran Med Sci, Endocrinol & Metab Clin Sci Inst, Endocrinol & Metab Res Ctr, Tehran, Iran.
   [Azmon, Marzyeh] Mashhad Univ Med Sci, Fac Med, Dept Internal Med, Mashhad, Iran.
C3 Tehran University of Medical Sciences; Tehran University of Medical
   Sciences; Tehran University of Medical Sciences; Tehran University of
   Medical Sciences; Mashhad University of Medical Sciences
RP Panahi, G (corresponding author), Univ Tehran Med Sci, Fac Med, Dept Clin Biochem, Tehran, Iran.
EM pshahriyar@gmail.com
RI panahi, shahriyar/W-3772-2019; Tabatabaei-Malazy, ozra/T-5561-2017;
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NR 117
TC 2
Z9 2
U1 0
U2 0
PU SPRINGER INT PUBL AG
PI CHAM
PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND
EI 2251-6581
J9 J DIABETES METAB DIS
JI J. Diabetes Metab. Disord.
PD DEC
PY 2024
VL 23
IS 2
BP 1753
EP 1771
DI 10.1007/s40200-024-01502-7
EA OCT 2024
PG 19
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA N4L5Z
UT WOS:001339713900002
PM 39610486
DA 2025-06-11
ER

PT J
AU Tomas, E
   Wood, JA
   Stanojevic, V
   Habener, JF
AF Tomas, E.
   Wood, J. A.
   Stanojevic, V.
   Habener, J. F.
TI Glucagon-like peptide-1(9-36)amide metabolite inhibits weight gain and
   attenuates diabetes and hepatic steatosis in diet-induced obese mice
SO DIABETES OBESITY & METABOLISM
LA English
DT Article
DE animal pharmacology; antidiabetic drug; antiobesity drug; diabetes
   mellitus; energy expenditure; energy regulation; GLP-1; insulin
   resistance; metabolic syndrome
ID HIGH-FAT DIET; INSULIN-RESISTANCE; PEPTIDE-1 RECEPTOR; NEUTRAL
   ENDOPEPTIDASE-24.11; TISSUE DISTRIBUTION; INCRETIN RECEPTORS;
   ENERGY-EXPENDITURE; GLUCOSE-PRODUCTION; OXIDATIVE STRESS; MOUSE MODEL
AB Aims: The metabolic syndrome, a disease arising from the world-wide epidemic of obesity, is manifested as severe insulin resistance, hyperlipidaemia, hepatic steatosis and diabetes. Previously we reported that GLP-1(9-36)amide, derived from the gluco-incretin hormone, glucagon-like peptide-1 (GLP-1), suppresses gluconeogenesis in isolated hepatocytes. The aims of this study were to determine the effects of GLP-1(9-36) amide in diet-induced obese mice that model the development of the metabolic syndrome.
   Methods: Mice rendered obese by feeding a very high fat diet were administered GLP-1(9-36) amide via subcutaneous osmopumps for 8 weeks. Body weight, energy intake, plasma insulin and glucose levels (insulin-resistance), and hepatic steatosis were assessed.
   Results: Eight-week infusions of GLP-1(9-36) amide inhibited weight gain, increased energy intake, prevented the development of fasting hyperinsulinaemia and hyperglycaemia, and curtailed the accumulation of liver triglycerides. The peptide had no effects in mice fed a normal chow diet. Notably, energy intake in the obese mice receiving GLP-1(9-36) amide was 20% greater than obese mice receiving vehicle control.
   Conclusions: GLP-1(9-36) amide exerts insulin-like actions in the presence of insulin resistance and prevents the development of metabolic syndrome. Curtailment of weight gain in the face of increased caloric intake suggests that GLP-1(9-36) amide increases energy expenditure. These findings suggest the possibility of the use of GLP-1(9-36) amide, or a peptide mimetic derived there from, for the treatment of obesity, insulin resistance and the metabolic syndrome.
C1 [Tomas, E.; Wood, J. A.; Stanojevic, V.; Habener, J. F.] Massachusetts Gen Hosp, Mol Endocrinol Lab, Boston, MA 02114 USA.
C3 Harvard University; Harvard University Medical Affiliates; Massachusetts
   General Hospital
RP Habener, JF (corresponding author), Massachusetts Gen Hosp, Mol Endocrinol Lab, 55 Fruit St Wellman 306,Thier 306, Boston, MA 02114 USA.
EM Jhabener@partners.org
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NR 44
TC 39
Z9 53
U1 0
U2 8
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1462-8902
EI 1463-1326
J9 DIABETES OBES METAB
JI Diabetes Obes. Metab.
PD JAN
PY 2011
VL 13
IS 1
BP 26
EP 33
DI 10.1111/j.1463-1326.2010.01316.x
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 686LQ
UT WOS:000284698200004
PM 21114600
DA 2025-06-11
ER

PT J
AU Muammer, K
   Mutluay, F
   Demir, R
   Özkan, AA
AF Muammer, Kiymet
   Mutluay, Fatma
   Demir, Rengin
   Ozkan, Alev Arat
TI Effects of peripheral and different inspiratory muscle training methods
   in coronary artery disease patients with metabolic syndrome: A
   randomized-controlled trial
SO RESPIRATORY MEDICINE
LA English
DT Article
DE Coronary artery disease; Metabolic syndrome; Neuromuscular electrical
   stimulation; Inspiratory muscle training; Peripheral muscle training
ID LUNG-FUNCTION; RESISTANCE EXERCISE; CARDIOVASCULAR RISK; STRENGTH;
   PREVALENCE; PARAMETERS; LIFE
AB Background
   Objective: To investigate the effects of peripheral muscle training (PMT) and different inspiratory muscle training (IMT) methods on respiratory functions, exercise capacity, and biochemistry parameters in coronary artery disease patients with metabolic syndrome.
   Methods: This prospective, single-blind, randomized-controlled study included 60 patients of stable coronary artery disease with metabolic syndrome (New York Heart Association [NYHA] Class I-II, left ventricular ejection fraction >40%). Patients were randomly divided into three groups: neuromuscular electrical stimulation (NMES) plus PMT group (NMES + PMT group, n = 20), IMT plus PMT group (IMT + PMT group, n = 20) and PMT group (PMT group, n = 20). Treatment continued for six weeks for all groups. The NMES was applied to rectus abdominis, IMT was applied with 30% of maximal inspiratory pressures, and PMT was applied at home. Spirometry, maximal inspiratory and expiratory pressure, dyspnea scores, exercise stress test, and biochemistry parameters were measured before and after training.
   Results: There were significant improvements in spirometric tests, respiratory muscle strength, dyspnea scores, exercise capacity, fasting blood glucose, and antistreptolysin O after treatment in all groups (p < 0.05). Significant improvements in C-reactive protein and erythrocyte sedimentation rate were observed in NMES + PMT and IMT + PMT groups (p < 0.05). Among the groups, there was a significant difference in maximal inspiratory pressure (p = 0.02) and erythrocyte sedimentation rate (p = 0.037) in favor of NMES + PMT group (p < 0.05).
   Conclusion: Our study results showed significant improvements in respiratory functions, exercise capacity, and biochemistry markers in all groups. Different IMT methods can be used in cardiopulmonary rehabilitation to improve exercise intolerance in coronary artery disease patients with metabolic syndrome.
C1 [Muammer, Kiymet; Demir, Rengin; Ozkan, Alev Arat] Istanbul Univ Cerrahpasa, Cardiol Inst, Dept Cardiol, Istanbul, Turkey.
   [Mutluay, Fatma] Medipol Univ, Fac Hlth Sci, Dept Physiotherapy & Rehabil, Istanbul, Turkey.
C3 Istanbul University - Cerrahpasa; Istanbul Medipol University
RP Mutluay, F (corresponding author), Ekinciler Cad 19 Kavacik Kavsagi Beykoz, TR-34810 Istanbul, Turkey.
EM fmutluay@medipol.edu.tr
RI MUTLUAY, Fatma/JVN-5548-2024; Mutluay, Fatma/G-1975-2015; Arat-Ozkan,
   Alev/A-8073-2016
OI Demir, Rengin/0000-0002-2901-2967; Mutluay, Fatma/0000-0003-1432-0913;
   Arat-Ozkan, Alev/0000-0001-8064-7231; Muammer,
   Kiymet/0000-0002-7640-7267
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NR 42
TC 5
Z9 7
U1 1
U2 10
PU W B SAUNDERS CO LTD
PI LONDON
PA 32 JAMESTOWN RD, LONDON NW1 7BY, ENGLAND
SN 0954-6111
EI 1532-3064
J9 RESP MED
JI Respir. Med.
PD OCT
PY 2020
VL 172
AR 106119
DI 10.1016/j.rmed.2020.106119
PG 10
WC Cardiac & Cardiovascular Systems; Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System
GA OD6UR
UT WOS:000579986900004
PM 32877886
OA Bronze
DA 2025-06-11
ER

PT J
AU Bowles, NP
   Hill, MN
   Bhagat, SM
   Karatsoreos, IN
   Hillard, CJ
   McEwen, BS
AF Bowles, N. P.
   Hill, M. N.
   Bhagat, S. M.
   Karatsoreos, I. N.
   Hillard, C. J.
   McEwen, B. S.
TI CHRONIC, NONINVASIVE GLUCOCORTICOID ADMINISTRATION SUPPRESSES LIMBIC
   ENDOCANNABINOID SIGNALING IN MICE
SO NEUROSCIENCE
LA English
DT Review
DE CB1; cannabinoid; 2-AG; anandamide; stress; corticosterone
ID N-ARACHIDONYLETHANOLAMINE ANANDAMIDE; CHRONIC UNPREDICTABLE STRESS;
   CANNABINOID RECEPTOR; CHRONIC CORTICOSTERONE; METABOLIC SYNDROME;
   RESTRAINT STRESS; BRAIN; SYSTEM; DEPRESSION; AMYGDALA
AB Limbic endocannabinoid signaling is known to be sensitive to chronic stress; however, studies investigating the impact of prolonged exposure to glucocorticoid hormones have been limited by the concurrent exposure to the stress of daily injections. The present study was designed to examine the effects of a noninvasive approach to alter plasma corticosterone (CORT) on the endocannabinoid system. More precisely, we explored the effects of a 4-week exposure to CORT dissolved in the drinking water of mice (100 mu g/ml) and measured cannabinoid CB1 receptor binding, endocannabinoid content, activity of the endocannabinoid degrading enzyme fatty acid amide hydrolase (FAAH), and mRNA expression of both the CB1 receptor and FAAH in both the hippocampus and amygdala. Our data demonstrate that CORT decreases CB1 receptor binding site density in both the hippocampus and amygdala and also reduced anandamide (AEA) content and increased FAAH activity within both structures. These changes in both CB1 receptor binding and FAAH activity were not accompanied by changes in mRNA expression of either the CB1 receptor or FAAH in either brain region. Interestingly, our CORT delivery regimen significantly increased 2-AG concentrations within the hippocampus, but not the amygdala. Collectively, these data demonstrate that the confounder of injection stress is sufficient to conceal the ability of protracted exposure to glucocorticoids to reduce CB1 receptor density and augment AEA metabolism within limbic structures.
   This article is part of a Special Issue entitled: Stress, Emotional Behavior and the Endocannabinoid System. (C) 2011 IBRO. Published by Elsevier Ltd. All rights reserved.
C1 [Bowles, N. P.; Hill, M. N.; Bhagat, S. M.; Karatsoreos, I. N.; McEwen, B. S.] Rockefeller Univ, Neuroendocrinol Lab, New York, NY 10021 USA.
   [Hillard, C. J.] Med Coll Wisconsin, Dept Pharmacol & Toxicol, Milwaukee, WI 53226 USA.
C3 Rockefeller University; Medical College of Wisconsin
RP Bowles, NP (corresponding author), Rockefeller Univ, Neuroendocrinol Lab, New York, NY 10021 USA.
EM nbowles@rockefeller.edu
RI Hill, Matthew/J-4610-2013; Karatsoreos, Ilia/AAR-8774-2020; McEwen,
   Bruce/Z-1630-2019; Hillard, Cecilia/O-6693-2018
OI Bhagat, Sarah M/0000-0003-1108-6244; Hillard,
   Cecilia/0000-0002-9678-748X
FU NIMH NIH HHS [R01 MH041256, T32 MH015125] Funding Source: Medline
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NR 36
TC 48
Z9 58
U1 0
U2 1
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4522
J9 NEUROSCIENCE
JI Neuroscience
PD MAR 1
PY 2012
VL 204
SI SI
BP 83
EP 89
DI 10.1016/j.neuroscience.2011.08.048
PG 7
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 906FT
UT WOS:000301331000009
PM 21939741
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Khalil, RG
   Atia, T
   Yousef, AI
   Sakr, HI
   Ahmed, OM
AF Khalil, Rehab G.
   Atia, Tarek
   Yousef, Ahmed I.
   Sakr, Hader Ibrahim
   Ahmed, Osama M.
TI Role of irisin in metabolic and cardiovascular disorders and its
   therapeutic potential
SO BENI-SUEF UNIVERSITY JOURNAL OF BASIC AND APPLIED SCIENCES
LA English
DT Review
DE Irisin; Obesity; Diabetes; Cardiovascular disorders; Molecular
   mechanism; Therapeutic role
ID IMPROVES ENDOTHELIAL FUNCTION; MESSENGER-RNA EXPRESSION; CIRCULATING
   IRISIN; ADIPOSE-TISSUE; INSULIN-RESISTANCE; SERUM-LEVELS;
   DIABETES-MELLITUS; OXIDATIVE STRESS; MYOKINE IRISIN; CELL-SURVIVAL
AB Irisin, a myokine produced by cleaving fibronectin type III domain-containing protein 5 (FNDC5), is a key regulator of metabolic processes and cardiovascular health. Its discovery in 2012 sparked significant interest due to its potential to impact fat and glucose metabolism, convert white fat to brown, and reduce inflammation-crucial in managing metabolic syndrome, obesity, and diabetes. Found in various tissues, including the brain, liver, heart, kidneys, and skeletal muscle, irisin has been linked to improved metabolic dysregulation and increased energy expenditure. Moreover, it has the potential to enhance endothelial function, reduce oxidative stress, and possibly regulate blood pressure, all contributing to improved cardiovascular health. This review explores the promising potential of irisin as a treatment for cardiovascular diseases (CVDs), metabolic syndrome, and related conditions. While more research is needed to fully understand its pathways, the future of irisin-based therapies in clinical settings looks promising.
C1 [Khalil, Rehab G.; Yousef, Ahmed I.; Ahmed, Osama M.] Beni Suef Univ, Fac Sci, Bani Suwayf, Egypt.
   [Atia, Tarek] Prince Sattam bin Abdulaziz Univ Al Kharj, Coll Appl Med Sci, Dept Med Labs, Al Kharj, Saudi Arabia.
   [Sakr, Hader Ibrahim] Cairo Univ, Fac Med, Dept Med Physiol, Cairo, Egypt.
   [Sakr, Hader Ibrahim] Batterjee Med Coll, Dept Med Physiol, Gen Med Practice Program, Jeddah 21442, Saudi Arabia.
C3 Egyptian Knowledge Bank (EKB); Beni Suef University; Prince Sattam Bin
   Abdulaziz University; Egyptian Knowledge Bank (EKB); Cairo University;
   Batterjee Medical College
RP Sakr, HI (corresponding author), Cairo Univ, Fac Med, Dept Med Physiol, Cairo, Egypt.; Sakr, HI (corresponding author), Batterjee Med Coll, Dept Med Physiol, Gen Med Practice Program, Jeddah 21442, Saudi Arabia.
EM rehab.khalil@science.bsu.edu.eg; t.mohamed@psau.edu.sa;
   ahmedismail_sc@yahoo.com; hadersakr@kasralainy.edu.eg;
   osama.ahmed@science.bsu.edu.eg
RI Sakr, Hader/AAC-1140-2022; Ahmed, Osama/P-8126-2018
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NR 180
TC 0
Z9 0
U1 1
U2 1
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
EI 2314-8543
J9 BENI-SUEF U J BASIC
JI Beni-Suef Univ. J. Basic Appl. Sci.
PD MAY 30
PY 2025
VL 14
IS 1
AR 55
DI 10.1186/s43088-025-00643-9
PG 18
WC Multidisciplinary Sciences
WE Emerging Sources Citation Index (ESCI)
SC Science & Technology - Other Topics
GA 3FQ9U
UT WOS:001499214700002
DA 2025-06-11
ER

PT J
AU Knight, JM
   Avery, EF
   Janssen, I
   Powell, LH
AF Knight, Jennifer M.
   Avery, Elizabeth F.
   Janssen, Imke
   Powell, Lynda H.
TI Cortisol and Depressive Symptoms in a Population-Based Cohort of Midlife
   Women
SO PSYCHOSOMATIC MEDICINE
LA English
DT Article
DE diurnal cortisol; depressive symptoms; midlife women; women's health
ID MENOPAUSAL TRANSITION; METABOLIC SYNDROME; SALIVARY CORTISOL; MAJOR
   DEPRESSION; LATE-LIFE; STRESS; MOOD; RISK; PREMENOPAUSAL; DISEASE
AB Objective: To determine whether there is a relationship between depressive symptoms and cortisol assessed at first morning awakening, 6 PM, and 9 PM in a population-based sample of midlife women. If this relationship is not linear, we aim to test whether this relationship is nonlinear, only present in those with more severe depressive symptoms, better accounted for by diurnal slope, or only apparent under uncontaminated conditions. Methods: We investigated the cross-sectional association between cortisol and depressive symptoms, assessed by the Center for Epidemiological Studies Depression scale (CES-D) in 408 midlife women (45.7% African Americans, 54.3% white; mean age, 50.4 years) participating in the Chicago site of the Study of Women's Health Across the Nation. Results: Diurnal cortisol slope is significantly flatter for women with higher CES-D scores than for less depressed women (p < .05 for the interaction). This relationship remains significant even after adjusting for age, smoking status, race, education, income, menopausal status, hormone replacement therapy, body mass index, medications, and wake time, as well as possibly contaminating factors, including physical activity, smoking, eating, or caffeine or alcohol consumption before saliva collection. Results using depression assessed categorically (CES-D cutoff >= 16) were similar to those using continuous depression in both unadjusted and adjusted analyses (p = .005 for the interaction of CES-D by time). Conclusions: In this population-based sample of midlife women, greater depressive symptoms were associated with a significantly flatter diurnal cortisol slope than those with fewer symptoms, even after adjusting for covariates and possibly contaminating behaviors.
C1 [Knight, Jennifer M.] Rush Univ, Med Ctr, Dept Internal Med, Chicago, IL 60612 USA.
   [Knight, Jennifer M.] Rush Univ, Med Ctr, Dept Psychiat, Chicago, IL 60612 USA.
   [Avery, Elizabeth F.; Janssen, Imke; Powell, Lynda H.] Rush Univ, Med Ctr, Dept Prevent Med, Chicago, IL 60612 USA.
C3 Rush University; Rush University; Rush University
RP Knight, JM (corresponding author), Univ Rochester, Med Ctr, Dept Psychiat, 300 Crittenden Blvd, Rochester, NY 14642 USA.
EM Jennifer_Knight@urmc.rochester.edu
OI Knight, Jennifer/0000-0002-9140-3109; Janssen, Imke/0000-0003-1184-2812
FU National Institutes of Health (NIH); Department of Health and Human
   Services, through the National Institute on Aging (NIA); National
   Institute of Nursing Research (NINR); NIH Office of Research on Women's
   Health (ORWH) [NR004061, AG012505, AG012535, AG012531, AG012539,
   AG012546, AG012553, AG012554, AG012495]; National Heart, Lung and Blood
   Institute (NHLBI) [HL067128]; Charles J. and Margaret Roberts Trust
FX The Study of Women's Health Across the Nation (SWAN) has received grant
   support from the National Institutes of Health (NIH), Department of
   Health and Human Services, through the National Institute on Aging
   (NIA), the National Institute of Nursing Research (NINR), and the NIH
   Office of Research on Women's Health (ORWH) (Grants NR004061; AG012505,
   AG012535, AG012531, AG012539, AG012546, AG012553, AG012554, AG012495).
   The SWAN Fat Patterning Study is supported by Grant HL067128 from the
   National Heart, Lung and Blood Institute (NHLBI) and the Charles J. and
   Margaret Roberts Trust.
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   Woods NF, 2008, MENOPAUSE, V15, P223, DOI 10.1097/gme.0b013e3181450fc2
NR 45
TC 41
Z9 48
U1 0
U2 10
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0033-3174
EI 1534-7796
J9 PSYCHOSOM MED
JI Psychosom. Med.
PD NOV-DEC
PY 2010
VL 72
IS 9
BP 855
EP 861
DI 10.1097/PSY.0b013e3181f4ab87
PG 7
WC Psychiatry; Psychology; Psychology, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry; Psychology
GA 685ZA
UT WOS:000284665400004
PM 20841562
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Olijhoek, JK
   Hajer, GR
   van der Graaf, Y
   Dallinga-Thie, GM
   Visseren, FLJ
AF Olijhoek, Jobien K.
   Hajer, Gideon R.
   van der Graaf, Yolanda
   Dallinga-Thie, Geesje M.
   Visseren, Frank L. J.
TI The effects of low-dose simvastatin and ezetimibe compared to high-dose
   simvastatin alone on post-fat load endothelial function in patients with
   metabolic syndrome: A randomized double-blind crossover trial
SO JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
LA English
DT Article
DE metabolic syndrome; statins; ezetimibe; postprandial lipid profiles;
   endothelial function
ID C-REACTIVE PROTEIN; SHORT-TERM; HYPERCHOLESTEROLEMIC PATIENTS;
   INSULIN-RESISTANCE; VASCULAR FUNCTION; OXIDATIVE STRESS; CHOLESTEROL;
   THERAPY; ATHEROSCLEROSIS; DYSFUNCTION
AB Background and Aims: Insulin resistance is associated with postprandial hyperlipidemia and endothelial dysfunciton. Patients with metabolic syndrome, characterized by insulin resistance, are at increased cardiovascular risk. The aim of the present study was to investigate wheather a similar low-density lipoprotein cholesterol (LDL-c) reduction with combination therapy of low-dose simvastatin and ezetimibe or with high-dose simvastatin alone has similar effects on (post-fat load) endothelial function.
   Methods: Randomized, double blind, crossover trial in 19 male obese patients with metabolic syndrome with high-dose simvastatin 80 mg versus combination therapy of low-dose simvastatin 10 mg with ezerimibe 10 mg. Fasting and post-fat load lipids and endothelial function (brachial artery flow-mediated dilation) were determined.
   Results: Fasting LDL-c concentrations (2.1 +/- 0.5 mmol/L) and fasting endothelial function (6.9 +/- 0.8 vs. 7.6 +/- 1.2%) were the same after both treatments. Although post-fat load plasma triglycerides concentrations were highr (3.2 +/- 0.4 vs. 2.6 +/- 0.2 mmol.h/L) with combination therapy compared to monotherapy, ApoB particles were comparable (0.9 +/- 3.3 vs. -0.2 +/- 2.3 g.h/L). Combination therapy did not decrease post-fat load endothelial function (7.6 +/- 1.2 vs. 7.7 +/- 1.6%) contrary to high-dose simvcastatin monotherapy (6.9 +/- 7.7 +/- 1.6%).
   conclusions: Combination therapy with low-dose simvastatin and ezetimibe preserved post-fat load endothelial function, contrary to treatment with high-dose simvastatin monotherapy in male metabolic syndrome patients. There were no differences in fasting lipid profiles and endothelial function.
C1 [van der Graaf, Yolanda] UMC Utrecht, Julius Ctr Hlth Sci & Primary Care, Amsterdam, Netherlands.
   [Dallinga-Thie, Geesje M.] Univ Amsterdam, Acad Med Ctr, Dept Vasc Med, Lab Expt Vasc Med, NL-1105 AZ Amsterdam, Netherlands.
   [Olijhoek, Jobien K.; Hajer, Gideon R.; Visseren, Frank L. J.] UMC Utrecht, Dept Vasc Med, Amsterdam, Netherlands.
C3 University of Amsterdam; Academic Medical Center Amsterdam
RP Visseren, FLJ (corresponding author), UMC Utrecht, Sect Vasc Med, F02-126 Heidelberglaan 100, NL-3584 CX Utrecht, Netherlands.
EM f.l.j.visseren@umcutrecht.nl
RI Visseren, Frank/I-4855-2013
OI dallinga-thie, geesje/0000-0001-5412-5923; Visseren,
   Frank/0000-0003-3951-5223
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NR 31
TC 41
Z9 45
U1 0
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0160-2446
EI 1533-4023
J9 J CARDIOVASC PHARM
JI J. Cardiovasc. Pharmacol.
PD AUG
PY 2008
VL 52
IS 2
BP 145
EP 150
DI 10.1097/FJC.0b013e31817ffe76
PG 6
WC Cardiac & Cardiovascular Systems; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Pharmacology & Pharmacy
GA 342QG
UT WOS:000258798000005
PM 18670365
OA Bronze
DA 2025-06-11
ER

PT J
AU Camargo, A
   Meneses, ME
   Rangel-Zuñiga, OA
   Perez-Martinez, P
   Marin, C
   Delgado-Lista, J
   Paniagua, JA
   Tinahones, FJ
   Roche, H
   Malagon, MM
   Perez-Jimenez, F
   Lopez-Miranda, J
AF Camargo, Antonio
   Meneses, Maria E.
   Rangel-Zuniga, Oriol A.
   Perez-Martinez, Pablo
   Marin, Carmen
   Delgado-Lista, Javier
   Paniagua, Juan A.
   Tinahones, Francisco J.
   Roche, Helen
   Malagon, Maria M.
   Perez-Jimenez, Francisco
   Lopez-Miranda, Jose
TI Endoplasmic reticulum stress in adipose tissue determines postprandial
   lipoprotein metabolism in metabolic syndrome patients
SO MOLECULAR NUTRITION & FOOD RESEARCH
LA English
DT Article
DE Adipose tissue; Diet; Endoplasmic reticulum stress; Metabolic syndrome;
   Postprandial state
ID CHAPERONE GENE-EXPRESSION; ER STRESS; OBESITY; LIVER; ACTIVATION;
   APOPTOSIS; CERAMIDE; GLUCOSE; CELLS; MODEL
AB ScopeOur aim was to ascertain whether the quality and quantity of fat in the diet may influence the ER stress at the postprandial state in adipose tissue by analyzing the gene expression of chaperones, folding enzymes, and activators of the UPR.
   Methods and resultsA randomized, controlled trial conducted within the LIPGENE study assigned 39 MetS patients to one of four diets: high-SFA (HSFA; 38% energy (E) from fat, 16% E as SFA), high MUFA (HMUFA; 38% E from fat, 20% E as MUFA), and two low-fat, high-complex carbohydrate (LFHCC; 28% E from fat) diets supplemented with 1.24 g/day of long-chain n-3 PUFA or placebo for 12 wk each. A fat challenge reflecting the same fatty acid composition as the original diets was conducted post intervention. sXBP-1 is induced in the postprandial state irrespective of the diet consumed (p < 0.001). BiP increases postprandially after consumption of diets HMUFA (p = 0.006), LFHCC (p = 0.028), and LFHCCn-3 (p = 0.028). Postprandial mRNA expression levels of CRL, CNX, PDIA3, and GSTP1 in AT did not differ between the different types of diets.
   ConclusionOur results suggest that upregulation of the unfolded protein response at the postprandial state may represent an adaptive mechanism to counteract diet-induced stress.
C1 [Camargo, Antonio; Meneses, Maria E.; Rangel-Zuniga, Oriol A.; Perez-Martinez, Pablo; Marin, Carmen; Delgado-Lista, Javier; Paniagua, Juan A.; Perez-Jimenez, Francisco; Lopez-Miranda, Jose] Univ Cordoba, Lipids & Atherosclerosis Unit, Reina Sofia Univ Hosp, IMIBIC, E-14004 Cordoba, Spain.
   [Camargo, Antonio; Meneses, Maria E.; Rangel-Zuniga, Oriol A.; Perez-Martinez, Pablo; Marin, Carmen; Delgado-Lista, Javier; Paniagua, Juan A.; Tinahones, Francisco J.; Malagon, Maria M.; Perez-Jimenez, Francisco; Lopez-Miranda, Jose] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr CIBEROBN, Madrid, Spain.
   [Tinahones, Francisco J.] Hosp Virgen de la Victoria, Biomed Res Lab, Malaga, Spain.
   [Roche, Helen] Univ Coll Dublin, UCD Inst Food & Hlth, UCD Conway Inst, Sch Publ Hlth & Populat Sci, Dublin, Ireland.
   [Malagon, Maria M.] Univ Cordoba, Dept Cell Biol Physiol & Immunol, E-14004 Cordoba, Spain.
C3 Universidad de Cordoba; Instituto de Salud Carlos III; CIBER - Centro de
   Investigacion Biomedica en Red; CIBEROBN; University College Dublin;
   Universidad de Cordoba
RP Lopez-Miranda, J (corresponding author), Univ Cordoba, Inst Salud Carlos III, Reina Sofia Univ Hosp, Lipids & Atherosclerosis Unit,IMIBIC, Av Menendez Pidal S-N, E-14004 Cordoba, Spain.
EM jlopezmir@uco.es
RI Delgado-Lista, Javier/KAM-7412-2024; Jimenez, Francisco/AAJ-9559-2021;
   Lopez-Miranda, Jose/Y-8306-2019; Marin Hinojosa, Carmen/AFO-1294-2022;
   Tinahones, Francisco/AAB-2882-2020; Camargo Garcia, Antonio/G-9720-2015;
   Perez Martinez, Pablo/AEL-6176-2022; MALAGON, MARIA M/L-5386-2014;
   Meneses, Maria E./Q-2572-2018
OI Camargo Garcia, Antonio/0000-0002-0415-4184; Perez Jimenez,
   Francisco/0000-0001-9808-1280; Lopez-Miranda, Jose/0000-0002-8844-0718;
   Tinahones, Francisco J/0000-0001-6871-4403; Perez Martinez,
   Pablo/0000-0001-7716-8117; , Juan A. Paniagua/0000-0003-2892-980X;
   Delgado Lista, Francisco Javier/0000-0002-2982-2716; Rangel-Zuniga,
   Oriol Alberto/0000-0003-3495-5705; Roche, Helen/0000-0002-0628-3318;
   MALAGON, MARIA M/0000-0002-2419-2727; Meneses, Maria
   E./0000-0002-7689-7024; Perez-Jimenez, Francisco/0000-0001-7499-7681
FU European Union [LIPGENE European Integrated Project] [505944];
   Ministerio de Ciencia e Innovacion [AGL2004-07907, AGL2006-01979,
   AGL2009-12270]; CIBER Fisiopatologia de la Obesidad y Nutricion
   [CB06/03/0047]; Consejeria de Innovacion, Ciencia y Empresa, Junta de
   Andalucia [P06-CTS-01425, CTS-03039, CTS-6606]; Consejeria de Salud,
   Junta de Andalucia [06/128, 07/43, PI-0193]; Fondo Europeo de Desarrollo
   Regional (FEDER); Consejo Nacional de Ciencia y Tecnologia, Mexico
   (CONACYT)
FX The CIBEROBN is an initiative of the Instituto de Salud Carlos III,
   Madrid, Spain. We would like to thank M<SUP>a</SUP> Jose Gomez-Luna for
   her technical support. This work was funded partly by research grants
   from the European Union [LIPGENE European Integrated Project-505944],
   from the Ministerio de Ciencia e Innovacion [grant numbers
   AGL2004-07907, AGL2006-01979, AGL2009-12270 (to J. L.-M.)]; CIBER
   Fisiopatologia de la Obesidad y Nutricion [grant number CB06/03/0047];
   Consejeria de Innovacion, Ciencia y Empresa, Junta de Andalucia [grant
   number P06-CTS-01425 (to J. L.-M.) CTS-03039 and CTS-6606 (to MMM)]; and
   Consejeria de Salud, Junta de Andalucia [grant numbers 06/128, 07/43,
   PI-0193 (to J. L.-M.)]); Fondo Europeo de Desarrollo Regional (FEDER).
   M. E. M. had a fellowship from the Consejo Nacional de Ciencia y
   Tecnologia, Mexico (CONACYT).
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NR 47
TC 8
Z9 10
U1 0
U2 23
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1613-4125
EI 1613-4133
J9 MOL NUTR FOOD RES
JI Mol. Nutr. Food Res.
PD DEC
PY 2013
VL 57
IS 12
BP 2166
EP 2176
DI 10.1002/mnfr.201300036
PG 11
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA 293AZ
UT WOS:000329945100008
PM 23934773
DA 2025-06-11
ER

PT J
AU Mohammadi-Sartang, M
   Babajafari, S
   Kohansal, A
   Rostami, H
   Pourmahmoudi, A
   Sohrabi, Z
AF Mohammadi-Sartang, Mohsen
   Babajafari, Siavash
   Kohansal, Atefeh
   Rostami, Hosein
   Pourmahmoudi, Azizollah
   Sohrabi, Zahra
TI Effects of daily functional acorn cake consumption on insulin resistance
   in individuals with obesity or overweight and the metabolic syndrome: a
   placebo-controlled randomised clinical trial
SO BRITISH JOURNAL OF NUTRITION
LA English
DT Article
DE Metabolic syndrome; Obesity; Acorn; Oak
ID QUERCUS SPP.; ANTIOXIDANT ACTIVITY; OXIDATIVE STRESS; ADIPONECTIN;
   ASSOCIATION; WEIGHT; ACID; INTERVENTION; INFLAMMATION; SENSITIVITY
AB The metabolic syndrome is a multi-factorial condition and functional foods need more investigation as novel adjunct treatments for this group. This study aimed to determine the effects of daily consumption of a functional acorn cake in conjunction with energy restriction (119.50 kJ) on individuals with overweight or obesity and the metabolic syndrome. In this randomised double-blinded study, eighty-four participants were randomly allocated to either an energy-restricted diet plus two servings (2 x 30 g)/d of functional acorn cake (a cake made of acorn for the intervention group) (FC) (n 42) or an energy-restricted diet plus placebo cake (PC) (n 42). Body composition and biochemical parameters were measured before and after 10 weeks of intervention. Seventy-three participants completed this trial. No differences in loss of body weight, waist circumference, fat mass, fasting blood glucose and blood pressure were shown between two groups. Body weight decreased by 4 center dot 2 (sd 1 center dot 9) kg and 5 center dot 1 (sd 2 center dot 8) kg in PC and FC groups, respectively. Compared with PC, the consumption of FC resulted in a significant reduction in serum insulin (P = 0 center dot 02), homoeostasis model assessment for insulin resistance (P = 0 center dot 02), high-sensitivity C-reactive protein (P = 0 center dot 04) and a significant increase in adiponectin concentration (P = 0 center dot 04). Although lipid metabolism did not differ among groups, total cholesterol and HDL-cholesterol improved non-significantly in the FC group. Functional acorn cake as an adjunct to energy restriction could possibly improve insulin resistance in individuals with obesity. Further research is needed to elucidate whether functional acorn cake can be used as a preventive strategy for the metabolic syndrome in individuals with obesity.
C1 [Mohammadi-Sartang, Mohsen; Babajafari, Siavash; Kohansal, Atefeh; Sohrabi, Zahra] Shiraz Univ Med Sci, Nutr Res Ctr, Shiraz, Iran.
   [Rostami, Hosein] Baqiyatallah Univ Med Sci, Hlth Res Ctr, Life Style Inst, Tehran, Iran.
   [Pourmahmoudi, Azizollah] Yasuj Univ Med Sci, Sch Hlth & Nutr, Dept Nutr, Yasuj, Iran.
C3 Shiraz University of Medical Science; Baqiyatallah University of Medical
   Sciences (BMSU); Yasouj University
RP Rostami, H (corresponding author), Baqiyatallah Univ Med Sci, Hlth Res Ctr, Life Style Inst, Tehran, Iran.
EM hoseinrostami2043@gmail.com
RI Esfandabad, Siavash/A-6807-2019; pourmahmoudi, azizollah/HSA-8811-2023;
   Sohrabi, Zahra/R-4948-2017
FU Nutrition Research Center, Shiraz University of Medical Sciences
FX A special thanks goes to the staff of 'Noono namak' bakery workshop for
   providing the cakes. We also thank Mr Hamid reza Raiesi and Mr Reza
   Barati for their spiritual supports. The present study was supported by
   the Nutrition Research Center, Shiraz University of Medical Sciences. M.
   M., H. R. and S. B. designed the study protocol; M. M., H. R., A. K., Z.
   S. and S. B. contributed to the data collection, data analysis,
   interpretation of results and manuscript drafting; M. M., A. P., H. R.,
   Z. S. and S. B. contributed to the editing and revision of the
   manuscript. All authors read and approved the final version of the
   paper. There are no conflicts of interest.
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NR 47
TC 1
Z9 2
U1 1
U2 5
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1145
EI 1475-2662
J9 BRIT J NUTR
JI Br. J. Nutr.
PD APR 14
PY 2023
VL 129
IS 7
BP 1142
EP 1150
AR PII S0007114522002288
DI 10.1017/S0007114522002288
EA AUG 2022
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA H5AM0
UT WOS:000840558300001
PM 39655470
DA 2025-06-11
ER

PT J
AU Suvarna, CM
   Raju, RS
   Malothu, N
   Guntupalli, C
AF Suvarna, Ch. Malathi
   Raju, Subhakar R.
   Malothu, Narender
   Guntupalli, Chakravarthi
TI Investigation of Lupinus angustifolius Extracts against
   High-Fructose Diet-Induced Metabolic Syndrome in Male Wistar Rats
SO PHARMACOGNOSY RESEARCH
LA English
DT Article
DE Lupinus angustifolius; Simvastatin; Oxidative stress; Hepatic lipid
   regulation; Hematological parameters
AB Background: Metabolic syndrome is a global health concern, affecting a significant portion of the population worldwide. According to the World Health Organization (WHO), the prevalence of metabolic syndrome is increasing globally due to the rising of obesity and physical inactivity. Objectives: In the present study, we evaluated Lupinus angustifolius seeds for their potential in alleviating metabolic abnormalities associated with metabolic syndrome induced by High Fructose Diet. Materials and Methods: Hexane and ethyl acetate seeds extracts of L. angustifolius (HELA and EAELA) were screened for phytochemical constituents. Normoglycemic male albino Wistar rats were distributed into 6 groups with 6 in each. Fructose solution (10% w/v) administered p.o. for 8 weeks caused induction of Metabolic Disorder. The metabolic parameters were assessed and recorded before and after the administration of 200 mg/kg of extracts over 8 weeks. Results: Preliminary screening demonstrated the presence of flavonoids, alkaloids, glycosides among others from both extracts. HELA and EAELA showed a significant (p<0.001) decrease in obesity. They also led to significantly (p<0.001) decreased expression of inflammatory mediators like IL -6, TGF beta, and TNF-alpha. Hematological parameters exhibited improvement whereas HbA1C expressed a significant (p<0.001) increase in plasma insulin and HOMA IR revealed a significant (p<0.001) decrease in insulin resistance when compared to disease control. Metabolic hormone levels also showed a positive change after administration where leptin and adiponectin levels are decreased (p<0.001 and p<0.1 respectively) and gherlin levels were increased non -significantly (p<0.05). Antihyperlipidemic, antioxidant potential of the extracts was more proficient. Conclusion: The EAELA at 200 mg/kg displayed significant capacity in inhibiting the Metabolic Syndrome induced by High fructose diet when compared to that of HELA at 200 mg/kg which was effective in comparison with Standard.
C1 [Suvarna, Ch. Malathi; Raju, Subhakar R.; Malothu, Narender; Guntupalli, Chakravarthi] Koneru Lakshmaiah Educ Fdn, Dept Pharmacognosy & Phytochem, KL Coll Pharm, Guntur, Andhra Pradesh, India.
C3 Koneru Lakshmaiah Education Foundation (K L Deemed to be University)
RP Guntupalli, C (corresponding author), Koneru Lakshmaiah Educ Fdn, Dept Pharmacognosy & Phytochem, KL Coll Pharm, Guntur, Andhra Pradesh, India.
EM chakravarthi123@kluniversity.in
RI Malothu, Narender/ABF-6269-2020
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NR 17
TC 1
Z9 1
U1 0
U2 1
PU PHCOG NET
PI KARNATAKA
PA 17, 2ND FLR, BUDDHA VIHAR RD, NEAR SPORTS ZONE, COX TOWN, BENGALURU,
   KARNATAKA, 560005, INDIA
SN 0974-8490
EI 0976-4836
J9 PHARMACOGN RES
JI Pharmacogn. Res.
PD APR-JUN
PY 2024
VL 16
IS 2
BP 391
EP 400
DI 10.5530/pres.16.2.49
PG 10
WC Pharmacology & Pharmacy
WE Emerging Sources Citation Index (ESCI)
SC Pharmacology & Pharmacy
GA E3C9E
UT WOS:001301823300021
OA hybrid
DA 2025-06-11
ER

PT J
AU Holder, MK
   Chassaing, B
AF Holder, Mary K.
   Chassaing, Benoit
TI Impact of food additives on the gut-brain axis
SO PHYSIOLOGY & BEHAVIOR
LA English
DT Article; Proceedings Paper
CT 25th Annual Meeting of the Society-for-the-Study-of-Ingestive-Behavior
   (SSIB)
CY JUL 18-22, 2017
CL Montreal, CANADA
SP Soc Study Ingest Behavior
DE Emulsifiers; Microbiota; Inflammation; Obesity; Anxiety
ID ANXIETY-LIKE BEHAVIOR; INFLAMMATORY BOWEL DISEASES; LOW-GRADE
   INFLAMMATION; NECROSIS-FACTOR-ALPHA; METABOLIC SYNDROME; MICROBIOTA
   COMPOSITION; INTESTINAL MICROBIOTA; INSULIN-RESISTANCE;
   COLORECTAL-CANCER; CROHNS-DISEASE
AB The mammalian intestinal tract is heavily colonized with a complex community of micro-organisms, present at a very high density, and containing an estimated amount of 10(14) bacteria. The microbiota generally benefits the host, as it plays a central role in maturing the immune system, protecting against infection by entero-pathogens such as Clostridium difficile, and favoring nutrient digestion/energy extraction in our intestine. An altered microbiota, however, can become detrimental and lead to inflammation, metabolic disorders, and even altered behavior/neuroinflammation. While there are many factors involved in regulating the intestinal microbiota composition and the way it interacts with its host, this review will focus on the role played by food additives on host/microbiota relationship.
C1 [Holder, Mary K.; Chassaing, Benoit] Georgia State Univ, Neurosci Inst, Atlanta, GA 30303 USA.
   [Chassaing, Benoit] Georgia State Univ, Inst Biomed Sci, Atlanta, GA 30303 USA.
C3 University System of Georgia; Georgia State University; University
   System of Georgia; Georgia State University
RP Chassaing, B (corresponding author), Georgia State Univ, Inst Biomed Sci, Neurosci Inst, Atlanta, GA 30303 USA.
EM bchassaing@gsu.edu
RI Chassaing, Benoit/R-3819-2017
OI Chassaing, Benoit/0000-0002-4285-769X; Holder, Mary/0000-0003-3585-1094
FU Crohn's and Colitis Foundation; Rainin Foundation; NIH [MH108345]
FX B.C. is a recipient of the Career Development Award from the Crohn's and
   Colitis Foundation and an Innovator Award from the Rainin Foundation.
   M.K.H. is supported by NIH grant MH108345. We thank Samantha Spencer
   (Georgia State University) for manuscript editing and Geert de Vries and
   Andrew T. Gewirtz (Georgia State University) for their precious
   mentoring.
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NR 59
TC 21
Z9 22
U1 0
U2 40
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0031-9384
J9 PHYSIOL BEHAV
JI Physiol. Behav.
PD AUG 1
PY 2018
VL 192
SI SI
BP 173
EP 176
DI 10.1016/j.physbeh.2018.02.025
PG 4
WC Psychology, Biological; Behavioral Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI); Conference Proceedings Citation Index - Science (CPCI-S); Conference Proceedings Citation Index - Social Science &amp; Humanities (CPCI-SSH)
SC Psychology; Behavioral Sciences
GA GM5LW
UT WOS:000438179900021
PM 29454065
DA 2025-06-11
ER

PT J
AU Bhatti, JS
   Bhatti, GK
   Reddy, PH
AF Bhatti, Jasvinder Singh
   Bhatti, Gurjit Kaur
   Reddy, P. Hemachandra
TI Mitochondrial dysfunction and oxidative stress in metabolic disorders -
   A step towards mitochondria based therapeutic strategies
SO BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
LA English
DT Review
DE Metabolic syndrome; Mitochondria; Oxidative stress; Reactive oxygen
   species; Mitochondria-targeted antioxidants; Cardiovascular disease;
   Pre-diabetes; Type-2-diabetes; Obesity
ID OXYGEN-FREE-RADICALS; EXACERBATES CEREBRAL INFARCTION;
   ALZHEIMERS-DISEASE IMPLICATIONS; SKELETAL-MUSCLE MITOCHONDRIA; ACTIVATED
   PROTEIN-KINASE; TUMOR-NECROSIS-FACTOR; INSULIN-RESISTANCE; TARGETED
   ANTIOXIDANT; NEURODEGENERATIVE DISEASES; CALORIE RESTRICTION
AB Mitochondria are the powerhouses of the cell and are involved in essential functions of the cell, including ATP production, intracellular Ca2+ regulation, reactive oxygen species production & scavenging, regulation of apoptotic cell death and activation of the caspase family of proteases. Mitochondrial dysfunction and oxidative stress are largely involved in aging, cancer, age-related neurodegenerative and metabolic syndrome. In the last decade, tremendous progress has been made in understanding mitochondrial structure, function and their physiology in metabolic syndromes such as diabetes, obesity, stroke and hypertension, and heart disease. Further, progress has also been made in developing therapeutic strategies, including lifestyle interventions (healthy diet and regular exercise), pharmacological strategies and mitochondria-targeted approaches. These strategies were mainly focused to reduce mitochondrial dysfunction and oxidative stress and to maintain mitochondrial quality in metabolic syndromes. The purpose of our article is to highlight the recent progress on the mitochondrial role in metabolic syndromes and also summarize the progress of mitochondria-targeted molecules as therapeutic targets to treat metabolic syndromes. This article is part of a Special Issue entitled: Oxidative Stress and Mitochondrial Quality in Diabetes/Obesity and Critical Illness Spectrum of Diseases- edited by P. Hemachandra Reddy. (C) 2016 Elsevier B.V. All rights reserved.
C1 [Bhatti, Jasvinder Singh] Sri Guru Gobind Singh Coll, Dept Biotechnol & Bioinformat, Sect 26, Chandigarh 160019, India.
   [Bhatti, Jasvinder Singh; Reddy, P. Hemachandra] Texas Tech Univ, Hlth Sci Ctr, Garrison Inst Aging, 3601 4th St,MS 9424, Lubbock, TX 79430 USA.
   [Bhatti, Gurjit Kaur] Panjab Univ, UGC Ctr Excellence Nano Applicat, UIPS Bldg, Chandigarh 160014, India.
   [Reddy, P. Hemachandra] Texas Tech Univ, Hlth Sci Ctr, Cell Biol & Biochem Dept, 3601 4th St,MS 9424, Lubbock, TX 79430 USA.
   [Reddy, P. Hemachandra] Texas Tech Univ, Hlth Sci Ctr, Neurosci & Pharmacol Dept, 3601 4th St,MS 9424, Lubbock, TX 79430 USA.
   [Reddy, P. Hemachandra] Texas Tech Univ, Hlth Sci Ctr, Neurol Dept, 3601 4th St,MS 9424, Lubbock, TX 79430 USA.
   [Reddy, P. Hemachandra] Texas Tech Univ, Hlth Sci Ctr, Speech Dept, 3601 4th St,MS 9424, Lubbock, TX 79430 USA.
   [Reddy, P. Hemachandra] Texas Tech Univ, Hlth Sci Ctr, Language & Hearing Sci Dept, 3601 4th St,MS 9424, Lubbock, TX 79430 USA.
   [Reddy, P. Hemachandra] Texas Tech Univ, Hlth Sci Ctr, Garrison Inst Aging, South West Campus,6630 S Quaker Suite E,MS 7495, Lubbock, TX 79413 USA.
C3 Texas Tech University System; Texas Tech University Health Sciences
   Center Lubbock; Panjab University; Texas Tech University System; Texas
   Tech University Health Sciences Center Lubbock; Texas Tech University
   System; Texas Tech University Health Sciences Center Lubbock; Texas Tech
   University System; Texas Tech University Health Sciences Center Lubbock;
   Texas Tech University System; Texas Tech University Health Sciences
   Center Lubbock; Texas Tech University System; Texas Tech University
   Health Sciences Center Lubbock; Texas Tech University System; Texas Tech
   University Health Sciences Center Lubbock
RP Bhatti, JS (corresponding author), Sri Guru Gobind Singh Coll, Dept Biotechnol & Bioinformat, Sect 26, Chandigarh 160019, India.
EM jasvinderbhatti@yahoo.com
RI Bhatti, Jasvinder/AAC-4853-2019; Bhatti, Gurjit/AAU-6478-2020
FU NIH [AG042178, AG047812]; Garrison Family Foundation; University Grants
   Commission, India under Raman Post-Doctoral Research Fellowship in USA
   [5-82/2016 (IC)]
FX Work presented in this article is supported by NIH grants AG042178,
   AG047812 and the Garrison Family Foundation. Dr. Jasvinder Singh Bhatti
   is financially supported by the University Grants Commission, India
   under Raman Post-Doctoral Research Fellowship in USA [F.No. 5-82/2016
   (IC)].
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NR 232
TC 932
Z9 945
U1 11
U2 147
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0925-4439
EI 1879-260X
J9 BBA-MOL BASIS DIS
JI Biochim. Biophys. Acta-Mol. Basis Dis.
PD MAY
PY 2017
VL 1863
IS 5
SI SI
BP 1066
EP 1077
DI 10.1016/j.bbadis.2016.11.010
PG 12
WC Biochemistry & Molecular Biology; Biophysics; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Cell Biology
GA EU5BO
UT WOS:000401046800006
OA Green Accepted, Bronze
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Gerhard, T
   Akincigil, A
   Correll, CU
   Foglio, NJ
   Crystal, S
   Olfson, M
AF Gerhard, Tobias
   Akincigil, Ayse
   Correll, Christoph U.
   Foglio, Neil J.
   Crystal, Stephen
   Olfson, Mark
TI National Trends in Second-Generation Antipsychotic Augmentation for
   Nonpsychotic Depression
SO JOURNAL OF CLINICAL PSYCHIATRY
LA English
DT Article
ID TREATMENT-RESISTANT DEPRESSION; EXTENDED-RELEASE QUETIAPINE;
   STAR-ASTERISK-D; DOUBLE-BLIND; OLANZAPINE/FLUOXETINE COMBINATION;
   ADJUNCTIVE THERAPY; RISPERIDONE AUGMENTATION; CARDIOMETABOLIC RISK;
   INADEQUATE-RESPONSE; DISORDER
AB Objective: This study estimates national trends and patterns in use of second-generation antipsychotics (SGAs) for adjunctive treatment of nonpsychotic adult depression in office-based practice.
   Method: Twelve consecutive years (1999-2010) of the National Ambulatory Medical Care Survey were analyzed to estimate trends and patterns of adjunctive SGA treatment for adult (= 18 years) nonpsychotic depression in office-based visits. Adjunctive SGA use was examined among all office visits in which depression was diagnosed (N = 7,767), excluding visits with diagnoses for alternative SGA indications (schizophrenia, bipolar disorder, pervasive development disorder, psychotic depression, dementia) and those without an active antidepressant prescription.
   Results: From 1999 to 2010, 8.6% of adult depression visits included an SGA. SGA use rates increased from 4.6% in 1999-2000 to 12.5% in 2009-2010, with an adjusted odds ratio (AOR) for time trend of 2.78 (95% CI, 1.84-4.20). The increase in SGA augmentation was broad-based, with no significant differences in time trends between demographic and clinical subgroups. For the most recent survey years (2005-2010), SGA use rates were higher in visits to psychiatrists than to other physicians (AOR = 5.08; 95% CI, 2.96-8.73), visits covered by public than private insurance (AOR = 3.20; 95% CI, 2.25-4.54), visits with diagnosed major depressive disorder than other depressive disorders (AOR = 1.49; 95% CI, 1.08-2.06), and visits with diabetes, hyperlipidemia, or cardiovascular disease (AOR = 2.13; 95% CI, 1.12-4.03) and lower in visits by patients > 65 years than 18-44 years (AOR = 0.51; 95% CI, 0.32-0.82) and visits that included psychotherapy (AOR = 0.68; 95% CI, 0.47-0.96).
   Conclusions: Between 1999 and 2010, SGAs were increasingly accepted in the outpatient treatment of adult nonpsychotic depression. (C) Copyright 2014 Physicians Postgraduate Press, Inc.
C1 [Gerhard, Tobias; Akincigil, Ayse; Crystal, Stephen] Rutgers State Univ, Ctr Hlth Serv Res Pharmacotherapy Chron Dis Manag, Inst Hlth Hlth Care Policy & Aging Res, New Brunswick, NJ 08901 USA.
   [Akincigil, Ayse] Rutgers State Univ, Sch Social Work, New Brunswick, NJ 08901 USA.
   [Gerhard, Tobias; Foglio, Neil J.] Rutgers State Univ, Ernest Mario Sch Pharm, Dept Pharm Practice & Adm, New Brunswick, NJ 08901 USA.
   [Correll, Christoph U.] North Shore Long Isl Jewish Hlth Syst, Psychiat Res, Zucker Hillside Hosp, Glen Oaks, NY USA.
   [Olfson, Mark] Columbia Univ, Coll Phys & Surg, Dept Psychiat, New York, NY USA.
   [Olfson, Mark] New York State Psychiat Inst & Hosp, New York, NY 10032 USA.
C3 Rutgers University System; Rutgers University New Brunswick; Rutgers
   University System; Rutgers University New Brunswick; Rutgers University
   System; Rutgers University New Brunswick; Northwell Health; Columbia
   University; New York State Psychiatry Institute
RP Gerhard, T (corresponding author), Rutgers State Univ, Ernest Mario Sch Pharm, 112 Paterson St, New Brunswick, NJ 08901 USA.
EM tgerhard@rci.rutgers.edu
RI Olfson, Mark/AAA-8547-2021; Correll, Christoph/D-3530-2011
OI Gerhard, Tobias/0000-0002-8598-5771; Akincigil, Ayse/0000-0002-8624-5038
FU Agency for Healthcare Research & Quality-Centers for Education &
   Research on Therapeutics award [U19 HS021112-02]
FX This work was supported by Agency for Healthcare Research &
   Quality-Centers for Education & Research on Therapeutics award U19
   HS021112-02 for the Rutgers Center for Education and Research on Mental
   Health Therapeutics.
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NR 59
TC 33
Z9 36
U1 0
U2 11
PU PHYSICIANS POSTGRADUATE PRESS
PI MEMPHIS
PA P O BOX 752870, MEMPHIS, TN 38175-2870 USA
SN 0160-6689
EI 1555-2101
J9 J CLIN PSYCHIAT
JI J. Clin. Psychiatry
PD MAY
PY 2014
VL 75
IS 5
BP 490
EP U206
DI 10.4088/JCP.13m08675
PG 10
WC Psychology, Clinical; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA AI9LZ
UT WOS:000337255400012
PM 24500284
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Ge, Q
   Brichard, S
   Yi, X
   Li, QF
AF Ge, Qian
   Brichard, Sonia
   Yi, Xu
   Li, QiFu
TI microRNAs as a New Mechanism Regulating Adipose Tissue Inflammation in
   Obesity and as a Novel Therapeutic Strategy in the Metabolic Syndrome
SO JOURNAL OF IMMUNOLOGY RESEARCH
LA English
DT Review
ID TOLL-LIKE RECEPTORS; INSULIN-RESISTANCE; CELL DEVELOPMENT;
   GENE-EXPRESSION; INNATE IMMUNITY; HYPOXIA; STRESS; MICE; ADIPOGENESIS;
   ENDOTOXEMIA
AB Obesity is associated closely with the metabolic syndrome ( MS). It is well known that obesity-induced chronic inflammation plays a fundamental role in the pathogenesis of MS. White adipose tissue ( AT) is the primary site for the initiation and exacerbation of obesity-associated inflammation. Exploring the mechanisms of white AT inflammation and resetting the immunological balance in white AT could be crucial for the management of MS. Several prominent molecular mechanisms have been proposed to mediate inflammation in white AT, including hypoxia, endoplasmic reticulum stress, lipotoxicity, and metabolic endotoxemia. Recently, a growing body of evidence supports the role of miRNAs as a new important inflammatory mediator by regulating both the adaptive and innate immunity. This review will focus on the implication of miRNAs in white AT inflammation in obesity, and will also highlight the potential of miRNAs as targets for therapeutic intervention in MS as well as the challenges lying in miRNA-targeting therapeutics.
C1 [Ge, Qian; Li, QiFu] Chongqing Med Univ, Affiliated Hosp 1, Dept Endocrinol, Chongqing 400016, Peoples R China.
   [Brichard, Sonia] Univ Louvain, Inst Expt & Clin Res, Endocrinol Diabet & Nutr Unit, Med Sect, B-1200 Brussels, Belgium.
   [Yi, Xu] Third Mil Med Univ, Daping Hosp, Inst Surg Res, Neurol Unit, Chongqing 400042, Peoples R China.
C3 Chongqing Medical University; Universite Catholique Louvain; Army
   Medical University
RP Li, QF (corresponding author), Chongqing Med Univ, Affiliated Hosp 1, Dept Endocrinol, Chongqing 400016, Peoples R China.
EM liqifu@yeah.net
RI LI, QI/IUM-8577-2023; Brichard, Sonia/B-4597-2013
FU National Key Clinical Department Construction Project
FX This work was supported by grants from the National Key Clinical
   Department Construction Project.
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NR 92
TC 69
Z9 76
U1 1
U2 16
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2314-8861
EI 2314-7156
J9 J IMMUNOL RES
JI J Immunol. Res.
PY 2014
VL 2014
AR 987285
DI 10.1155/2014/987285
PG 10
WC Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology
GA AE2XK
UT WOS:000333836400001
PM 24741638
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Roberts, CK
   Won, D
   Pruthi, S
   Kurtovic, S
   Sindhu, RK
   Vaziri, ND
   Barnard, RJ
AF Roberts, CK
   Won, D
   Pruthi, S
   Kurtovic, S
   Sindhu, RK
   Vaziri, ND
   Barnard, RJ
TI Effect of a short-term diet and exercise intervention on oxidative
   stress, inflammation, MMP-9, and monocyte chemotactic activity in men
   with metabolic syndrome factors
SO JOURNAL OF APPLIED PHYSIOLOGY
LA English
DT Article
DE atherosclerosis; lipids; cell adhesion molecules; nitric oxide; matrix
   metalloproteinase-9
ID C-REACTIVE PROTEIN; LOW-DENSITY-LIPOPROTEIN; LOW-FAT DIET; LIFE-STYLE
   MODIFICATION; WEIGHT-LOSS; CARDIOVASCULAR-DISEASE; ENDOTHELIAL FUNCTION;
   ADHESION MOLECULES; INSULIN-RESISTANCE; P-SELECTIN
AB The present study was designed to examine the effects of lifestyle modification on key contributing factors to atherogenesis, including oxidative stress, inflammation, chemotaxis, and cell adhesion. Obese men (n = 31), 15 of whom had metabolic syndrome, were placed on a high-fiber, low-fat diet in a 3-wk residential program where food was provided ad libitum and daily aerobic exercise was performed. In each subject, pre- and postintervention fasting blood was drawn for circulating levels of serum lipids, glucose and insulin ( for estimation of insulin sensitivity), oxidative stress-generating enzyme myeloperoxidase and marker 8-isoprostaglandin F-2 alpha, the inflammatory protein C-reactive protein, soluble ICAM-1 as an indicator of endothelial activation, sP-selectin as a marker of platelet activation, the chemokine macrophage inflammatory protein-1 alpha, and total matrix metalloproteinase-9. Using subject sera and human aortic endothelial cell culture systems, we measured VCAM-1 cell surface abundance and monocyte chemotactic protein-1, nitric oxide, superoxide, and hydrogen peroxide production in vitro by fluorometric detection. Also determined in vitro was serum-induced, monocyte adhesion and monocyte chemotactic activity. After 3 wk, significant reductions (P < 0.05) in body mass index, all serum lipids and lipid ratios, fasting glucose, insulin, homeostasis model assessment for insulin resistance, myeloperoxidase, 8-isoprostaglandin F-2 alpha, C-reactive protein, soluble ICAM-1, soluble P-selectin, macrophage inflammatory protein-1 alpha, and matrix metalloproteinase-9 were noted. In vitro, serum-stimulated cellular VCAM-1 expression, monocyte chemotactic protein-1 production, and fluorometric detection of superoxide and hydrogen peroxide production decreased, whereas a concomitant increase in NO production was noted (all P < 0.01). Additionally, both monocyte adhesion (P < 0.05) and MCA (P < 0.01) decreased. Nine of 15 were no longer positive for metabolic syndrome postintervention. Intensive lifestyle modification may ameliorate novel coronary artery disease risk factors in men with metabolic syndrome factors before reversal of obesity. atherosclerosis; lipids; cell adhesion molecules; nitric oxide; matrix metalloproteinase-9.
C1 Univ Calif Los Angeles, Dept Physiol Sci, Los Angeles, CA 90095 USA.
   Charles R Drew Univ Med & Sci, Div Endocrinol Metab & Mol Med, Los Angeles, CA USA.
   Univ Calif Irvine, Dept Med, Div Nephrol & Hypertens, Irvine, CA USA.
C3 University of California System; University of California Los Angeles;
   Charles R. Drew University of Medicine & Science; University of
   California System; University of California Irvine
RP Univ Calif Los Angeles, Dept Physiol Sci, 4101 Life Sci Bldg 621 Charles E Young Dr S, Los Angeles, CA 90095 USA.
EM croberts@ucla.edu
FU NHLBI NIH HHS [F32 HL-68406-01] Funding Source: Medline
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NR 57
TC 172
Z9 196
U1 1
U2 15
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 8750-7587
EI 1522-1601
J9 J APPL PHYSIOL
JI J. Appl. Physiol.
PD MAY
PY 2006
VL 100
IS 5
BP 1657
EP 1665
DI 10.1152/japplphysiol.01292.2005
PG 9
WC Physiology; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology; Sport Sciences
GA 040DE
UT WOS:000237358400033
PM 16357066
DA 2025-06-11
ER

PT J
AU Puchkova-Sistac, A
   de Lauzon-Guillain, B
   Girerd, N
   Boivin, JM
   Bozec, E
   Merckle, L
   Nazare, JA
   Laville, M
   Rossignol, P
   Wagner, S
AF Puchkova-Sistac, Anfisa
   de Lauzon-Guillain, Blandine
   Girerd, Nicolas
   Boivin, Jean-Marc
   Bozec, Erwan
   Merckle, Ludovic
   Nazare, Julie-Anne
   Laville, Martine
   Rossignol, Patrick
   Wagner, Sandra
TI Association between eating behaviour and 13-year cardiovascular damages
   in the initially healthy STANISLAS cohort
SO EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
LA English
DT Article
DE Eating behaviour; Cardiovascular damage; Metabolic syndrome; Mediation
   analysis
ID LEFT-VENTRICULAR MASS; OBESITY; RISK; STIFFNESS; STRESS; DESIGN; STYLE;
   INTERVENTIONS; RECRUITMENT; DISEASE
AB Aims Several dimensions of eating behaviour (EB), such as restrained eating (RE), appear to be cross-sectionally associated with certain cardiovascular (CV) diseases and metabolic risk factors although little is known regarding longitudinal associations. This study aimed to assess the associations between EB and CV damage or metabolic syndrome after 13 years, in initially healthy individuals.
   Methods and results This study included 1109 participants from the familial STANISLAS (Suivi Temporaire Annuel Non-Invasif de la Sante des Lorrains Assures Sociaux) cohort study. Emotional eating (EmE), RE, and external eating were assessed using the Dutch Eating Behaviour Questionnaire. Metabolic syndrome and CV damages such as carotid-femoral pulse-wave velocity (cfPWV), left ventricular mass, carotid intima-media thickness, and diastolic dysfunction (DD) were measured after a period of 13 years. Mixed model analysis with a family random effect and adjustment for age, sex, education, temporal gap, physical activity, metabolic factors at baseline, and the onset of CV disease during follow-up, and mediation analysis were performed in adults and adolescents separately. Among adults, EmE was associated with a 38% increased risk of DD 13 years later [odds ratio = 1.38 (1.05; 1.83)]. Stress level mediated 31.9% of this association (P = 0.01). Emotional eating was positively associated with cfPWV (beta=0.02 [0.01; 0.04]). External eating was slightly associated with lower cfPWV (beta=-0.03 [-0.05; -0.01]). No associations were observed between EB dimensions and metabolic syndrome. Energy intake was not found to be a mediator of any associations.
   Conclusion Our results suggest that CV prevention should also take into account EB and include emotion regulation skills teaching.
   Lay Summary The association of three dimensions of eating behaviour [emotional eating, restrained eating, and external eating] with 13 years later cardiovascular damages have been investigated in the initially healthy STANISLAS (Suivi Temporaire Annuel Non-Invasif de la Sante des Lorrains Assures Sociaux) cohort. Emotional eating was associated with higher pulse-wave velocity and an increased risk of diastolic dysfunction. External eating was associated with lower pulse-wave velocity. Stress level was found to be a mediator of the association found between emotional eating and diastolic dysfunction.
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C1 [Puchkova-Sistac, Anfisa; Girerd, Nicolas; Boivin, Jean-Marc; Bozec, Erwan; Merckle, Ludovic; Rossignol, Patrick; Wagner, Sandra] Univ Lorraine, INI CRCT, FCRIN, INSERM CIC 1433,Nancy CHRU,Inserm U1116, 4 rue Morvan, F-54500 Vandoeuvre Les Nancy, France.
   [de Lauzon-Guillain, Blandine] Univ Paris Cite, Hop Hotel Dieu, CRESS, INRAE,INSERM, 1 Pl PARVIS NOTREDAME, F-75004 Paris, France.
   [Boivin, Jean-Marc] Univ Lorraine, Dept Gen Med, 9 Ave Foret Haye, F-54500 Vandoeuvre Les Nancy, France.
   [Nazare, Julie-Anne; Laville, Martine] Univ Lyon, Univ Claude Bernard Lyon 1, Hospices Civils Lyon,CarMeN Lab,INSERM,INRA,INSA, Ctr Rech Nutr Humaine Rhone Alpes,F CRIN FORCE Ne, 165 chemin Grand Revoyet, Pierre Benite, France.
C3 CHU de Nancy; Universite de Lorraine; Institut National de la Sante et
   de la Recherche Medicale (Inserm); Universite Paris Cite; INRAE;
   Institut National de la Sante et de la Recherche Medicale (Inserm);
   Assistance Publique Hopitaux Paris (APHP); Hopital Universitaire
   Hotel-Dieu - APHP; Universite de Lorraine; CHU Lyon; Institut National
   de la Sante et de la Recherche Medicale (Inserm); Universite Claude
   Bernard Lyon 1; INRAE
RP Girerd, N (corresponding author), Univ Lorraine, INI CRCT, FCRIN, INSERM CIC 1433,Nancy CHRU,Inserm U1116, 4 rue Morvan, F-54500 Vandoeuvre Les Nancy, France.
EM n.girerd@chru-nancy.fr
RI Wagner, Sandra/AAD-4918-2022; GIRERD, Nicolas/D-5493-2011; de
   Lauzon-Guillain, Blandine/P-4659-2016
OI Wagner, Sandra/0000-0002-3251-3754; de Lauzon-Guillain,
   Blandine/0000-0001-5887-8842; Puchkova, Anfisa/0000-0003-0174-4768;
   Girerd, Nicolas/0000-0002-3278-2057; Lab, Carmen/0000-0002-5935-3236
FU Centre Hospitalier Regional Universitaire de Nancy (CHRU); French
   Ministry of Solidarity and Health (Programme Hospitalier de Recherche
   Clinique Inter-regional); Contrat de Plan Etat-Lorraine; 'Fonds Europeen
   de Developpement Regional' (FEDER Lorraine); French National Research
   Agency (ANR) as part of the second 'Investissements d'Avenir' programme
   FIGHT-HF [ANR-15-RHU-0004]; French 'Projet investissement d'avenir
   '(PIA) project 'Lorraine Universite d'Excellence' [ANR-15-IDEX-04-LUE];
   European Union-Framework Program (EU-FP) Network of Excellence Ingenious
   HyperCare [LSHM-CT-2006-037093]; EU-FP MEDIA [261409,
   ANR-15-CE14-0032-01, 602904, ANR-16-ECVD-0002-02]; Agence Nationale de
   la Recherche (ANR) [ANR-16-ECVD-0002] Funding Source: Agence Nationale
   de la Recherche (ANR)
FX The 4th examination of the STANISLAS study was sponsored by the Centre
   Hospitalier Regional Universitaire de Nancy (CHRU) and supported by the
   French Ministry of Solidarity and Health (Programme Hospitalier de
   Recherche Clinique Inter-regional 2013), and by the Contrat de Plan
   Etat-Lorraine and the 'Fonds Europeen de Developpement Regional' (FEDER
   Lorraine), and by a public grant overseen by the French National
   Research Agency (ANR) as part of the second 'Investissements d'Avenir'
   programme FIGHT-HF (reference: ANR-15-RHU-0004) and by the French
   'Projet investissement d'avenir '(PIA) project 'Lorraine Universite
   d'Excellence' (reference ANR-15-IDEX-04-LUE). The STANISLAS study is
   also supported by the 6th European Union-Framework Program (EU-FP)
   Network of Excellence Ingenious HyperCare (#LSHM-CT-2006-037093), the
   s7th EU-FP MEDIA (Europeen 'Cooperation'-Theme
   'Health'/FP7-HEALTH-2010-single-stage #261409), HOMAGE (Heart 'Omics' in
   Ageing, 7th Framework Program grant #305507), FOCUS-MR (reference:
   ANR-15-CE14-0032-01), and FIBRO-TARGETS (FP7#602904) projects, and by
   ERA-CVD EXPERT (reference: ANR-16-ECVD-0002-02).
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NR 48
TC 4
Z9 4
U1 1
U2 5
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 2047-4873
EI 2047-4881
J9 EUR J PREV CARDIOL
JI Eur. J. Prev. Cardiol.
PD MAR 1
PY 2023
VL 30
IS 4
SI SI
BP 349
EP 357
DI 10.1093/eurjpc/zwac287
EA JAN 2023
PG 9
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 9M9DG
UT WOS:000911402800001
PM 36626936
OA Green Submitted, Bronze
DA 2025-06-11
ER

PT J
AU Panahi, Y
   Hosseini, MS
   Khalili, N
   Naimi, E
   Soflaei, SS
   Majeed, M
   Sahebkar, A
AF Panahi, Yunes
   Hosseini, Mahboobeh Sadat
   Khalili, Nahid
   Naimi, Effat
   Soflaei, Sara Saffar
   Majeed, Muhammed
   Sahebkar, Amirhossein
TI Effects of supplementation with curcumin on serum adipokine
   concentrations: A randomized controlled trial
SO NUTRITION
LA English
DT Article
DE Curcumin; Metabolic syndrome; Leptin; Adiponectin; Meta-analysis
ID PLACEBO-CONTROLLED TRIAL; QUALITY-OF-LIFE; CHRONIC PULMONARY
   COMPLICATIONS; SYSTEMIC OXIDATIVE STRESS; METABOLIC SYNDROME;
   INSULIN-RESISTANCE; DOUBLE-BLIND; SULFUR MUSTARD; PIPERINE COMBINATION;
   OBESE INDIVIDUALS
AB Objective: Previous experimental studies have suggested curcumin as a safe phytochemical that can improve insulin resistance through effects on adiponectin and leptin. This study aimed to investigate the effect of curcumin on circulating adiponectin and leptin concentrations in patients with metabolic syndrome.
   Methods: In this pilot, randomized, double-blind, placebo-controlled trial, subjects who met the criteria of metabolic syndrome according to the National Cholesterol Education Program Adult Treatment Panel III criteria were randomly assigned to curcumin (n = 59; 1000 mg/d) or a placebo (n = 58) for 8 wk. Serum adiponectin and leptin concentrations were determined before and after intervention. The pooled effect size for the impact of curcumin supplementation on serum adiponectin and leptin levels was also estimated using random-effects metaanalysis.
   Results: Eight-week supplementation with curcumin was associated with a significant increase in serum adiponectin levels (P < 0.001) and a reduction in serum leptin concentrations (P < 0.001). Serum leptin:adiponectin ratio was also improved by curcumin (P < 0.001). These beneficial effects of curcumin remained significant after adjustment for changes in serum lipids and glucose concentrations and baseline differences in body mass index and serum levels of glucose and glycated hemoglobin as potential confounders of treatment response. Metaanalysis suggested that curcumin supplementation can increase adiponectin levels by 76.78% (95% CI: 6.14-147.42; P = 0.0330), and reduce leptin by 26.49% (95% CI: 70.44 to 17.46), however this latter effect size did not reach statistical significance (P = 0.238).
   Conclusions: Curcumin can improve serum levels of adiponectin and leptin in patients with metabolic syndrome. This trial was registered at the UMIN Clinical Trials Registry (http://www.umin.ac.jp/ctri) under Trial No. UMIN000018339. (C) 2016 Elsevier Inc. All rights reserved.
C1 [Panahi, Yunes] Baqiyatallah Univ Med Sci, Chem Injuries Res Ctr, Tehran, Iran.
   [Hosseini, Mahboobeh Sadat; Khalili, Nahid; Naimi, Effat] Baqiyatallah Univ Med Sci, Dept Endocrinol, Tehran, Iran.
   [Soflaei, Sara Saffar] Mashhad Univ Med Sci, Neurogen Inflammat Res Ctr, Dept Modern Sci & Technol, Mashhad, Iran.
   [Majeed, Muhammed] Sabinsa Inc, Princeton, NJ USA.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Biotechnol Res Ctr, Mashhad, Iran.
   [Sahebkar, Amirhossein] Univ Western Australia, Royal Perth Hosp, Sch Med & Pharmacol, Metab Res Ctr, Perth, WA, Australia.
C3 Baqiyatallah University of Medical Sciences (BMSU); Baqiyatallah
   University of Medical Sciences (BMSU); Mashhad University of Medical
   Sciences; Mashhad University of Medical Sciences; East Metropolitan
   Health Service; Royal Perth Hospital; University of Western Australia
RP Sahebkar, A (corresponding author), Mashhad Univ Med Sci, Biotechnol Res Ctr, Mashhad, Iran.; Sahebkar, A (corresponding author), Univ Western Australia, Royal Perth Hosp, Sch Med & Pharmacol, Metab Res Ctr, Perth, WA, Australia.
EM Sahebkara@mums.ac.ir
RI naeimi, effat/U-3221-2019; Sahebkar, Amirhossein/B-5124-2018; Khalili,
   Nahid/U-1226-2019; Soflaei, Sara/AAI-1461-2019; Hosseini,
   Mahboobeh/U-9514-2018
OI Panahi, Yunes/0000-0002-2504-8356; Saffar Soflaei,
   Sara/0000-0001-6795-0623; hosseini, mahboobeh sadat/0000-0001-8863-1269;
   naeimi, effat/0000-0001-9513-3700
FU Clinical Trial Research Center (Tehran, Iran); Iran National Science
   Foundation [93015237]
FX This study was financially supported by Clinical Trial Research Center
   (Tehran, Iran) and Iran National Science Foundation (grant number:
   93015237). The authors gratefully acknowledge Sami Labs Ltd. (Bangalore,
   India) for providing the drug material used in this trial.
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NR 65
TC 74
Z9 77
U1 1
U2 22
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0899-9007
EI 1873-1244
J9 NUTRITION
JI Nutrition
PD OCT
PY 2016
VL 32
IS 10
BP 1116
EP 1122
DI 10.1016/j.nut.2016.03.018
PG 7
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA DU7YE
UT WOS:000382429700012
PM 27297718
OA Bronze
DA 2025-06-11
ER

PT J
AU Chielle, EO
   Trott, A
   Rosa, BD
   Casarin, JN
   Fortuna, PC
   da Cruz, BM
   Moretto, MB
   Moresco, RN
AF Chielle, E. O.
   Trott, A.
   Rosa, B. da Silva
   Casarin, J. N.
   Fortuna, P. C.
   da Cruz, B. M.
   Moretto, M. B.
   Moresco, R. N.
TI Impact of the Ile<SUP>105</SUP>Val Polymorphism of the Glutathione
   S-transferase P1 (GSTP1) Gene on Obesity and Markers of Cardiometabolic
   Risk in Young Adult Population
SO EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
LA English
DT Article
DE obesity; glutathione; polymorphism; biomarkers; cardiometabolic
ID OXIDATIVE STRESS; INSULIN-RESISTANCE; DIABETES-MELLITUS; GSTM1; GSTT1;
   CANCER; CELLS; METAANALYSIS; MECHANISMS; HUMANS
AB aim of the study was to investigate the association between Glutathione S-transferase P1 (GSTP1) gene polymorphism with obesity and markers of cardiometabolic risk. A cross-sectional study was carried out in individuals aged >= 18 and <= 30 years. The study included 54 normal weight, 27 overweight and 68 obese volunteers. Anthropometric measurements and biochemical parameters were evaluated, the DNA was extracted from blood samples and polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to measure GSTP1 Ile(105)Val gene polymorphism of the study participants. Also, biochemical analysis and hormone assays were carried out. A positive association between GSTP1 polymorphism and obesity was observed on subjects carrying at least one G allele (AG and GG). GG genotype was found only in the obese group. The G allele carriers presented 2.4 times higher chance of obesity when compared to those with the AA genotype. These results were independent of sex and age. We suggest that despite a study in population regional (south of Brazil), the GSTP1 gene polymorphism may play a significant role in the increase of susceptibility of obesity and contribute to identify the cardiovascular risk in young adults.
C1 [Chielle, E. O.; Moretto, M. B.; Moresco, R. N.] Univ Fed Santa Maria, Ctr Hlth Sci, Santa Maria, RS, Brazil.
   [da Cruz, B. M.] Univ Fed Santa Maria, Ctr Nat & Exact Sci, Santa Maria, RS, Brazil.
   [Chielle, E. O.; Trott, A.; Rosa, B. da Silva; Casarin, J. N.; Fortuna, P. C.] Univ Western Santa Catarina, UNOESC, Mol Biol Lab, Sao Miguel Do Oeste, SC, Brazil.
C3 Universidade Federal de Santa Maria (UFSM); Universidade Federal de
   Santa Maria (UFSM); Universidade do Oeste de Santa Catarina
RP Chielle, EO (corresponding author), Univ Fed Santa Maria, Ctr Hlth Sci, Santa Maria, RS, Brazil.; Chielle, EO (corresponding author), Univ Western Santa Catarina, UNOESC, Mol Biol Lab, Sao Miguel Do Oeste, SC, Brazil.
EM eduardochielle@yahoo.com
RI Moresco, Rafael/K-6118-2017; da Cruz; Manica da Cruz, Ivana/G-4329-2012
OI Moresco, Rafael/0000-0003-3072-5080; da Cruz; Manica da Cruz,
   Ivana/0000-0003-3008-6899
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NR 33
TC 11
Z9 11
U1 0
U2 2
PU JOHANN AMBROSIUS BARTH VERLAG MEDIZINVERLAGE HEIDELBERG GMBH
PI STUTTGART
PA RUEDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0947-7349
EI 1439-3646
J9 EXP CLIN ENDOCR DIAB
JI Exp. Clin. Endocrinol. Diabet.
PD MAY
PY 2017
VL 125
IS 5
BP 335
EP 341
DI 10.1055/s-0042-105279
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA FA7NR
UT WOS:000405633900010
PM 28561194
DA 2025-06-11
ER

PT J
AU da Silva, IV
   Santos, AC
   Matos, A
   da Silva, AP
   Soveral, G
   Rebelo, I
   Bicho, M
AF da Silva, Ines Vieira
   Santos, Ana Carolina
   Matos, Andreia
   da Silva, Alda Pereira
   Soveral, Graca
   Rebelo, Irene
   Bicho, Manuel
TI Association of Aquaporin-3, Aquaporin-7, NOS3 and CYBA polymorphisms
   with hypertensive disorders in women
SO PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR
   HEALTH
LA English
DT Article
DE Aquaporins; Polymorphisms; Oxidative Stress; Preeclampsia; Hypertension;
   Metabolic Syndrome
ID HYDROGEN-PEROXIDE; OXIDATIVE STRESS; CARDIOVASCULAR RISK; GENE;
   EXPRESSION; CHANNEL; PREECLAMPSIA; BLOOD; AQP9
AB Preeclampsia (PE), a pregnancy disorder influenced by oxidative stress and hypoxia, affects the health of the mother and baby and is associated with an increased risk of future hypertension (HT). Aquaporins are a family of water channels, comprising members that also transport glycerol (aquaglyceroporins) and hydrogen peroxide (peroxiporins), key molecules for metabolic homeostasis and redox signaling. Here, we investigated the association of Aquaporin-3 (AQP3; rs2231231), Aquaporin-7 (AQP7; rs2989924), NOS3 (4B/A intron) and CYBA (rs4673) genetic polymorphisms with the development of hypertensive disorders by qPCR/PCR in a cohort of 150 normotensive (NT) women (N = 90) or with previous PE (N = 60) during pregnancy. Prospectively, women were reclassified 2-16 years after pregnancy as NT (N = 98) or hypertensive (N = 48) and the genetic associations were reevaluated. In addition, genetic associations were reevaluated and compared between normotensive and hypertensive (HT) subjects. We found that AQP3 rs2231231, an aquaglyceroporin/peroxiporin, is associated with the development of HT, whereas AQP7, NOS3 and CYBA polymorphism did not correlate with PE or future HT. Because AQP3 was associated with hypertension only after pregnancy, its role might be related to later risk factors of hypertension such as metabolic syndrome or oxidative stress.
C1 [da Silva, Ines Vieira; Soveral, Graca] Univ Lisbon, Fac Farm, Res Inst Med iMedULisboa, Lisbon, Portugal.
   [da Silva, Ines Vieira; Soveral, Graca] Univ Lisbon, Fac Farm, Dept Ciencias Farmaceut & Med, Ave Prof Gama Pinto, P-1649003 Lisbon, Portugal.
   [Santos, Ana Carolina; Matos, Andreia; da Silva, Alda Pereira; Bicho, Manuel] Univ Lisbon, Fac Med, Inst Saude Ambiental, Lab Genet, P-1649026 Lisbon, Portugal.
   [Santos, Ana Carolina; Matos, Andreia; Bicho, Manuel] Inst Invest Cient Bento Rocha Cabral, Calcada Bento Da Rocha Cabral 14, P-1250012 Lisbon, Portugal.
   [Matos, Andreia] Univ Porto, I3S Inst Invest & Inovacao Saude, INEB Inst Biomed Engn, Rua Alfredo Allen 208, P-4200135 Porto, Portugal.
   [Matos, Andreia] Univ Porto, Abel Salazar Inst Biomed Sci ICBAS, Porto, Portugal.
   [Rebelo, Irene] Univ Porto, Fac Pharm, Dept Biol Sci, Biochem, Rua Jorge Viterbo Ferreira 228, P-4050313 Porto, Portugal.
   [Rebelo, Irene] Univ Porto, UCIBIO REQUIMTE, Porto, Portugal.
C3 Universidade de Lisboa; Universidade de Lisboa; Universidade de Lisboa;
   Universidade do Porto; i3S - Instituto de Investigacao e Inovacao em
   Saude, Universidade do Porto; Universidade do Porto; Universidade do
   Porto; Universidade do Porto
RP da Silva, IV (corresponding author), Univ Lisbon, Fac Farm, Ave Prof Gama Pinto, P-1649003 Lisbon, Portugal.
EM imsilva1@campus.ul.pt
RI Santos, Ana Carolina/GWR-2410-2022; Matos, Andreia/J-2410-2019; da
   Silva, Ines/ABH-6826-2020; Soveral, Graca/L-1550-2013
OI Oliveira, Alda Pereira da Silva/0000-0003-4496-2714; Soveral,
   Graca/0000-0001-8487-110X; Bicho, Manuel/0000-0002-5773-5687
FU Fundacao para a Ciencia e Tecnologia (FCT), Portugal [PD/BD/113634/2015,
   PTDC/BTM-SAL/28977/2017, UIDB/04138/2020, UIDP/04138/2020,
   UIDB/04378/2020]; Fundação para a Ciência e a Tecnologia
   [PD/BD/113634/2015] Funding Source: FCT
FX This research was funded by Fundacao para a Ciencia e Tecnologia (FCT),
   Portugal, through individual fellowship to IV da Silva
   (PD/BD/113634/2015), grant PTDC/BTM-SAL/28977/2017 and strategic
   projects UIDB/04138/2020 and UIDP/04138/2020 (iMed.ULisboa) and
   UIDB/04378/2020.
CR Agre P, 2004, ANGEW CHEM INT EDIT, V43, P4278, DOI 10.1002/anie.200460804
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NR 38
TC 6
Z9 6
U1 0
U2 6
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 2210-7789
J9 PREGNANCY HYPERTENS
JI Pregnancy Hypertens.
PD JUN
PY 2021
VL 24
BP 44
EP 49
DI 10.1016/j.preghy.2021.02.008
EA FEB 2021
PG 6
WC Obstetrics & Gynecology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology; Cardiovascular System & Cardiology
GA SI2LM
UT WOS:000654657600006
PM 33652340
DA 2025-06-11
ER

PT J
AU Barandas, R
   Landgraf, D
   McCarthy, MJ
   Welsh, DK
AF Barandas, Rita
   Landgraf, Dominic
   McCarthy, Michael J.
   Welsh, David K.
TI Circadian Clocks as Modulators of Metabolic Comorbidity in Psychiatric
   Disorders
SO CURRENT PSYCHIATRY REPORTS
LA English
DT Review
DE Circadian rhythm; Psychiatric disorders; Metabolic syndrome; Depression;
   Reward; Obesity
ID PITUITARY-ADRENAL AXIS; BIPOLAR DISORDER; ENERGY-METABOLISM;
   DIURNAL-VARIATION; MAJOR DEPRESSION; LEPTIN CONCENTRATIONS; REWARD;
   DOPAMINE; TIME; OBESITY
AB Psychiatric disorders such as schizophrenia, bipolar disorder, and major depressive disorder are often accompanied by metabolic dysfunction symptoms, including obesity and diabetes. Since the circadian system controls important brain systems that regulate affective, cognitive, and metabolic functions, and neuropsychiatric and metabolic diseases are often correlated with disturbances of circadian rhythms, we hypothesize that dysregulation of circadian clocks plays a central role in metabolic comorbidity in psychiatric disorders. In this review paper, we highlight the role of circadian clocks in glucocorticoid, dopamine, and orexin/melanin-concentrating hormone systems and describe how a dysfunction of these clocks may contribute to the simultaneous development of psychiatric and metabolic symptoms.
C1 [Barandas, Rita] Ctr Hosp Lisboa Norte, Hosp Santa Maria, Dept Psychiat, Lisbon, Portugal.
   [Barandas, Rita] Univ Lisbon, Fac Med, P-1699 Lisbon, Portugal.
   [Barandas, Rita; Landgraf, Dominic; McCarthy, Michael J.; Welsh, David K.] VA San Diego Healthcare Syst Psychiat Serv, La Jolla, CA USA.
   [Barandas, Rita; Landgraf, Dominic; McCarthy, Michael J.; Welsh, David K.] Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA.
   [Barandas, Rita; Landgraf, Dominic; McCarthy, Michael J.; Welsh, David K.] Univ Calif San Diego, Ctr Circadian Biol, La Jolla, CA 92093 USA.
C3 Universidade de Lisboa; Hospital Santa Maria; Universidade de Lisboa; US
   Department of Veterans Affairs; Veterans Health Administration (VHA); VA
   San Diego Healthcare System; University of California System; University
   of California San Diego; University of California System; University of
   California San Diego
RP Landgraf, D (corresponding author), VA San Diego Healthcare Syst Psychiat Serv, La Jolla, CA USA.
EM dlandgraf@ucsd.edu
RI ; McCarthy, Michael/K-9302-2017
OI Landgraf, Dominic/0000-0002-1328-1871; McCarthy,
   Michael/0000-0001-6219-4945
FU Veterans Affairs Merit Award [1I01BX001146]; NARSAD
FX Supported by a Veterans Affairs Merit Award (1I01BX001146) and a NARSAD
   Young Investigator Award to David K. Welsh. The authors declare no
   competing financial interests.
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NR 144
TC 53
Z9 54
U1 0
U2 34
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1523-3812
EI 1535-1645
J9 CURR PSYCHIAT REP
JI Curr. Psychiatry Rep.
PD DEC
PY 2015
VL 17
IS 12
AR 98
DI 10.1007/s11920-015-0637-2
PG 12
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA CZ0PI
UT WOS:000366807800006
PM 26483181
DA 2025-06-11
ER

PT J
AU Shiota, G
   Tsuchiya, H
AF Shiota, Goshi
   Tsuchiya, Hiroyuki
TI Pathophysiology of NASH: Insulin resistance, free fatty acids and
   oxidative stress
SO JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION
LA English
DT Review
DE NASH; insulin resistance; free fatty acid; oxidative stress
ID NONALCOHOLIC STEATOHEPATITIS; NATURAL-HISTORY; LIVER-DISEASE; OBESITY;
   STEATOSIS; MODELS
AB Nonalcoholic steatohepatitis (NASH) is a clinicopathological condition that comprises a wide spectrum of liver damage, ranging from steatohepatitis, advanced fibrosis and cirrhosis. NASH is the most common liver disease in the United States, with a high prevalence in the obese, type 2 diabetic population and metabolic syndrome. Although the pathophysiology of NASH remains to be clarified, insulin resistance, free fatty acids and oxidative stress are the most important causes. In this review article, I focused on insulin resistance, free fatty acids and oxidative stress as main causes of NASH, and described the outlines of the pathophysiology of NASH.
C1 Tottori Univ, Div Med & Mol Genet, Dept Genet Med & Regenerat Therapeut, Grad Sch Med, Yonago, Tottori 6838504, Japan.
C3 Tottori University
RP Shiota, G (corresponding author), Tottori Univ, Div Med & Mol Genet, Dept Genet Med & Regenerat Therapeut, Grad Sch Med, Yonago, Tottori 6838504, Japan.
EM gshiota@grape.med.tottori-u.ac.jp
RI Tsuchiya, Hiroyuki/AEQ-0473-2022
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NR 26
TC 12
Z9 15
U1 0
U2 13
PU JOURNAL CLINICAL BIOCHEMISTRY & NUTRITION
PI KYOTO
PA KYOTO PREFECTURAL UNIV MED, GRAD SCH MEDICAL SCIENCE, DEPT MOLECULAR
   GASTROENTEROLOGY & HEPATOLOGY, KYOTO, 602-8566, JAPAN
SN 0912-0009
EI 1880-5086
J9 J CLIN BIOCHEM NUTR
JI J. Clin. Biochem. Nutr.
PD MAY
PY 2006
VL 38
IS 3
BP 127
EP 132
DI 10.3164/jcbn.38.127
PG 6
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 044AS
UT WOS:000237645000001
OA Bronze
DA 2025-06-11
ER

PT J
AU Jenkins, TA
AF Jenkins, Trisha A.
TI Metabolic Syndrome and Vascular-Associated Cognitive Impairment: a Focus
   on Preclinical Investigations
SO CURRENT DIABETES REPORTS
LA English
DT Review
DE Vascular cognitive impairment; Vascular dementia; Cognition;
   Hippocampus; Prefrontal cortex; Preclinical models
ID CHRONIC CEREBRAL HYPOPERFUSION; TERM ENVIRONMENTAL ENRICHMENT;
   INFLAMMATORY MARKERS; ALZHEIMERS-DISEASE; PREFRONTAL CORTEX; OXIDATIVE
   STRESS; RODENT MODELS; DEMENTIA; RAT; HIPPOCAMPAL
AB Purpose of Review Metabolic syndrome is associated with an increased risk of vascular cognitive impairment or, in the more extreme, vascular dementia. Animal models are used to investigate the relationship between pathology and behaviour. This review summarizes the latest understanding of the role of the hippocampus and prefrontal cortex in vascular cognitive impairment, the influence of inflammation in this association while also commenting on some of the latest interventions proposed. Recent Findings Models of vascular cognitive impairment and vascular dementia, whether they develop from an infarct or non-infarct base, demonstrate increased neuroinflammation, reduced neuronal function and deficits in prefrontal and hippocampal-associated cognitive domains. Promising new research shows agents and environmental interventions that inhibit central oxidative stress and inflammation can reverse both pathology and cognitive dysfunction. While preclinical studies suggest that reversal of deficits in vascular cognitive impairment models is possible, replication in patients still needs to be demonstrated.
C1 [Jenkins, Trisha A.] RMIT Univ, STEM Coll, Sch Hlth & Biomed Sci, Human Biosci, Plenty Rd, Bundoora, Vic 3083, Australia.
C3 Royal Melbourne Institute of Technology (RMIT)
RP Jenkins, TA (corresponding author), RMIT Univ, STEM Coll, Sch Hlth & Biomed Sci, Human Biosci, Plenty Rd, Bundoora, Vic 3083, Australia.
EM trisha.jenkins@rmitedu.au
RI Jenkins, Trisha/C-8649-2009
OI Jenkins, Trisha/0000-0003-0137-6643
FU CAUL
FX Open Access funding enabled and organized by CAUL and its Member
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NR 87
TC 8
Z9 8
U1 2
U2 18
PU CURRENT MEDICINE GROUP
PI PHILADELPHIA
PA 400 MARKET STREET, STE 700, PHILADELPHIA, PA 19106 USA
SN 1534-4827
EI 1539-0829
J9 CURR DIABETES REP
JI Curr. Diabetes Rep.
PD AUG
PY 2022
VL 22
IS 8
BP 333
EP 340
DI 10.1007/s11892-022-01475-y
EA JUN 2022
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 3E4GP
UT WOS:000814955400002
PM 35737273
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Bonnefont-Rousselot, D
AF Bonnefont-Rousselot, Dominique
TI Obesity and Oxidative Stress: Potential Roles of Melatonin as
   Antioxidant and Metabolic Regulator
SO ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS
LA English
DT Article
DE Antioxidant; insulin resistance; melatonin; metabolic syndrome; obesity
ID BROWN ADIPOSE-TISSUE; KINASE-C-BETA; NECROSIS-FACTOR-ALPHA; HIGH-FAT
   DIET; REACTIVE OXYGEN; GLUTATHIONE-PEROXIDASE; CARDIOVASCULAR-DISEASE;
   INSULIN-RESISTANCE; BODY-WEIGHT; ADIPOCYTE DIFFERENTIATION
AB Obesity is associated with an oxidative stress status, defined as an excessive production of reactive oxygen species (ROS) compared to the level of antioxidants acting in the natural defence systems. Several sources of ROS can be identified in obesity (e. g., mitochondrial respiratory chain, or NADPH oxidase) and could contribute to the pathogenesis of obesity. Indeed, these conditions favour the development of insulin resistance and metabolic syndrome through deregulation of adipokines and pro-inflammatory cytokines, so that it could be of interest to associate antioxidant therapeutic strategies with strategies of weight loss. Among antioxidants, melatonin holds a special place, on the one hand for its antioxidant and anti-inflammatory properties, and on the other hand for its role as a metabolic regulator. As melatonin modulates several processes involved in obesity and its related metabolic alterations, it could have a therapeutic interest in the treatment of obesity.
C1 [Bonnefont-Rousselot, Dominique] Grp Hosp Pitie Salpetriere, AP HP, Serv Biochim Metab, F-75651 Paris 13, France.
   [Bonnefont-Rousselot, Dominique] Univ Paris 06, INSERM, ICAN, UMR S 1166, F-75013 Paris, France.
   [Bonnefont-Rousselot, Dominique] Univ Paris 05, Fac Pharm, F-75006 Paris, France.
C3 Assistance Publique Hopitaux Paris (APHP); Hopital Universitaire
   Pitie-Salpetriere - APHP; Sorbonne Universite; Institut National de la
   Sante et de la Recherche Medicale (Inserm); Sorbonne Universite;
   Universite Paris Cite
RP Bonnefont-Rousselot, D (corresponding author), Grp Hosp Pitie Salpetriere, AP HP, Serv Biochim Metab, 47-83 Blvd Hop, F-75651 Paris 13, France.
EM dominique.rousselot@psl.aphp.fr
RI Rousselot, Bonnefont/U-7434-2019
OI Bonnefont-Rousselot, Dominique/0000-0003-4689-9202
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NR 140
TC 28
Z9 30
U1 1
U2 12
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1871-5303
EI 2212-3873
J9 ENDOCR METAB IMMUNE
JI Endocr. Metab. Immune Disord.-Drug Targets
PY 2014
VL 14
IS 3
BP 159
EP 168
DI 10.2174/1871530314666140604151452
PG 10
WC Endocrinology & Metabolism; Immunology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Immunology; Pharmacology & Pharmacy
GA CA1CP
UT WOS:000348651000001
PM 24934925
DA 2025-06-11
ER

PT J
AU Ghanbarijolfaie, A
   Pirhayati, M
   Mazaheri, M
   Naderi, Z
   Eftekhar, M
   Chegini, L
AF Ghanbarijolfaie, Atefeh
   Pirhayati, Mohammad
   Mazaheri, Maryam
   Naderi, Zahra
   Eftekhar, Mehrdad
   Chegini, Leila
TI Obesity, marital satisfaction and depression affect Iranian female
   sexual function
SO SEXUAL AND RELATIONSHIP THERAPY
LA English
DT Article
DE Obesity; body mass index; female sexual function index; ENRICH marital;
   Satisfaction Scale; Beck Depression Inventory
ID QUALITY-OF-LIFE; METABOLIC SYNDROME; BODY-WEIGHT; INDEX FSFI;
   DYSFUNCTION; WOMEN; HEALTH; PREVALENCE; GENDER; MEN
AB The current study aimed to evaluate the effects of obesity on Iranian female sexual dysfunction (FSD). Married women were included in two groups of patients with Body Mass Index BMI >= 30 and control with normal BMI. The two groups were compared using the Female Sexual Function Index (FSFI), ENRICH Marital Satisfaction Scale, and Beck Depression Inventory (BDI). The correlations between BMI, marital satisfaction, depression, age, education marriage duration, and FSFI were analyzed using a linear regression test and correlation analysis. The FSFI scores in both groups were done. Despite the desire, other domains of FSFI showed significant differences among the groups. The mean of the ENRICH Marital Satisfaction Scale in test and control groups was evaluated. Also, BDI showed significant differences among both groups. Moreover, FSFI showed a direct correlation with ENRICH and an inverse correlation with BDI. Consequently, according to the results, obesity can influence the Iranian FSD.
C1 [Ghanbarijolfaie, Atefeh] Iran Univ Med Sci, Psychiat Res Dept, Tehran, Iran.
   [Pirhayati, Mohammad] Iran Univ Med Sci, Gen Med Dept, Dept Neurol, Tehran, Iran.
   [Mazaheri, Maryam; Eftekhar, Mehrdad] Iran Univ Med Sci, Mental Hlth Res Ctr, Tehran, Iran.
   [Naderi, Zahra] Iran Univ Med Sci, Obstet & Gynecol Dept, Tehran, Iran.
C3 Iran University of Medical Sciences; Iran University of Medical
   Sciences; Iran University of Medical Sciences; Iran University of
   Medical Sciences
RP Chegini, L (corresponding author), AJA Univ Med Sci, Internal Med Dept, Tehran, Iran.
EM leychegini@gmail.com
RI naderi, zahra/AAE-5918-2022
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NR 69
TC 0
Z9 0
U1 0
U2 0
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 1468-1994
EI 1468-1749
J9 SEX RELATSH THER
JI Sex. Relatsh. Ther.
PD APR 3
PY 2025
VL 40
IS 2
BP 383
EP 395
DI 10.1080/14681994.2025.2456975
EA JAN 2025
PG 13
WC Psychology, Clinical
WE Social Science Citation Index (SSCI)
SC Psychology
GA 1SN3E
UT WOS:001417180200001
DA 2025-06-11
ER

PT J
AU Shearrer, GE
   Daniels, MJ
   Toledo-Corral, CM
   Weigensberg, MJ
   Spruijt-Metz, D
   Davis, JN
AF Shearrer, G. E.
   Daniels, M. J.
   Toledo-Corral, C. M.
   Weigensberg, M. J.
   Spruijt-Metz, D.
   Davis, J. N.
TI Associations among sugar sweetened beverage intake, visceral fat, and
   cortisol awakening response in minority youth
SO PHYSIOLOGY & BEHAVIOR
LA English
DT Article
DE Adolescences; Cortisol awakening response; Visceral adipose tissue;
   Sugar-sweetened beverage
ID SOFT DRINK CONSUMPTION; ADIPOSE-TISSUE; METABOLIC SYNDROME; GLYCEMIC
   INDEX; CARDIOMETABOLIC RISK; INSULIN SENSITIVITY; DIETARY SUGAR;
   UNITED-STATES; ACUTE STRESS; OVERWEIGHT
AB Context: Abdominal adiposity has long been associated with excess caloric intake possibly resulting from increased psychosocial stress and associated cortisol dysfunction. However, the relationship of sugar-sweetened beverage (SSB) intake specifically with cortisol variability and visceral adipose tissue (VAT) is unknown.
   Objective: To examine the relationships between SSB intake, VAT, and cortisol response in minority youth.
   Design: A cross-sectional analysis. Setting: The University of Southern California.
   Participants: 60 overweight/obese Non-Hispanic Black and Hispanic adolescents ages 14-18 years.
   Main outcome measures: VAT via Magnet Resonance Imaging (MRI), cortisol awakening response (CAR) via multiple salivary samples, and SSB intake via multiple 24-hour diet recalls. SSB intake was divided into the following: low SSB consumers (<1 servings per day), medium SSB consumers (>= 1-<2 servings per day), high SSB consumers (>= 2 servings per day). Analysis of covariance were run with VAT and CAR as dependent variables and SSB intake categories (independent variable) with the following a priori covariates: sex, Tanner stage, ethnicity, caloric intake, and body mass index.
   Results: The high SSB intake group exhibited a 7% higher VAT compared to the low SSB intake group (beta = 0.25, CI: (0.03, 0.33), p = 0.02). CAR was associated with VAT (beta= 031, CI: (0.01,0.23), p = 0.02). The high SSB intake group exhibited 22% higher CAR compared to the low SSB intake group (beta = 0.30, CI: (0.02,0.48), p = 0.04).
   Conclusion: This is the first study exploring the relationship between SSB, VAT, and CAR. SSB consumption appears to be independently associated greater abdominal adiposity and higher morning cortisol variability in overweight and obese minority youth. This study highlights potential targets for interventions specifically to reduce SSB intake in a minority youth population. (C) 2016 Elsevier Inc. All rights reserved.
C1 [Shearrer, G. E.; Davis, J. N.] Univ Texas Austin, Dept Nutr, Austin, TX 78712 USA.
   [Daniels, M. J.] Univ Texas Austin, Dept Stat & Data Sci, Austin, TX 78712 USA.
   [Daniels, M. J.] Univ Texas Austin, Dept Integrat Biol, Austin, TX 78712 USA.
   [Toledo-Corral, C. M.] Calif State Univ Los Angeles, Dept Publ Hlth, Los Angeles, CA 90032 USA.
   [Weigensberg, M. J.] Univ Southern Calif, Inst Integrat Hlth, Dept Pediat, Keck Sch Med, Los Angeles, CA 90089 USA.
   [Spruijt-Metz, D.] Univ Southern Calif, Ctr Econ & Social Res, Los Angeles, CA 90089 USA.
C3 University of Texas System; University of Texas Austin; University of
   Texas System; University of Texas Austin; University of Texas System;
   University of Texas Austin; California State University System;
   California State University Los Angeles; Los Angeles County Department
   of Public Health; University of Southern California; University of
   Southern California
RP Shearrer, GE (corresponding author), Univ Texas Austin, Dept Nutr Sci, 100 East 24th St,Norman Hackerman Bldg, Austin, TX 78712 USA.
EM graceshearrer@utexas.edu
RI Toledo-Corral, Claudia/J-5299-2019; Davis, Jaimie/AAU-7800-2021
OI Toledo-Corral, Claudia/0000-0002-1228-9070; Daniels,
   Michael/0000-0002-9856-9486
FU NCMHD [P60MD002254]
FX The authors of this paper report no conflicts of interest. DSM and MJW
   were responsible for research design and oversaw all data collection.
   JND oversaw the dietary data collection. CMT performed quality control
   on all clinical and survey data. GES and MJD analyzed the data and
   preformed statistical analysis. GES, JND, DSM, and MJW were involved in
   the data interpretation. GES, JND, DSM, CMT, MJD, and MJVV provided
   edits for the paper. This study is supported by NCMHD grant P60MD002254
   (MI Goran; M.J. Weigensberg for Project 1).
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NR 62
TC 20
Z9 24
U1 1
U2 17
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0031-9384
J9 PHYSIOL BEHAV
JI Physiol. Behav.
PD DEC 1
PY 2016
VL 167
BP 188
EP 193
DI 10.1016/j.physbeh.2016.09.020
PG 6
WC Psychology, Biological; Behavioral Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Behavioral Sciences
GA EC3SX
UT WOS:000388047700022
PM 27660033
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Moreno-Fernández, S
   Garcés-Rimón, M
   González, C
   Uranga, JA
   López-Miranda, V
   Vera, G
   Miguel, M
AF Moreno-Fernandez, S.
   Garces-Rimon, M.
   Gonzalez, C.
   Uranga, J. A.
   Lopez-Miranda, V.
   Vera, G.
   Miguel, M.
TI Pepsin egg white hydrolysate ameliorates metabolic syndrome in
   high-fat/high-dextrose fed rats
SO FOOD & FUNCTION
LA English
DT Article
ID SPONTANEOUSLY HYPERTENSIVE-RATS; LONG-TERM INTAKE; OXIDATIVE STRESS;
   ENZYMATIC-HYDROLYSIS; INSULIN-RESISTANCE; HIGH-FAT; PEPTIDES; DIET;
   OBESITY; PROTEINS
AB The aim of this study was to examine the effect of a pepsin egg white hydrolysate (EWH) on metabolic complications using a high-fat/high-dextrose diet-induced Metabolic Syndrome (MetS) experimental model. Male Wistar rats were divided into 4 groups which received: standard diet and water (C), standard diet and a solution with 1 g kg(-1) day(-1) of EWH (CH), high-fat/high-dextrose diet and water (MS), and high-fat/high-dextrose diet and a solution with 1 g kg(-1) day(-1) of EWH (MSH). EWH consumption normalized body weight gain; abdominal obesity and peripheral neuropathy developed in MetS animals, and adipose tissue and liver weight, as well as plasma glucose were reduced. Oxidative stress and inflammation biomarkers were normalized in MSH animals. In conclusion, the oral administration of EWH could be used as a functional food ingredient to improve some complications associated with MetS induced by unhealthy diets.
C1 [Moreno-Fernandez, S.; Garces-Rimon, M.; Miguel, M.] UAM, CSIC, Inst Invest Ciencias Alimentac CIAL, Madrid, Spain.
   [Moreno-Fernandez, S.; Garces-Rimon, M.; Gonzalez, C.; Uranga, J. A.; Lopez-Miranda, V.; Vera, G.] CSIC, Inst Invest Ciencias Alimentac CIAL, Unidad Asociada I D I, Madrid, Spain.
   [Gonzalez, C.; Uranga, J. A.; Lopez-Miranda, V.; Vera, G.; Miguel, M.] Univ Rey Juan Carlos, Fac Ciencias Salud, Ciencias Basicas Salud, Madrid, Spain.
   [Uranga, J. A.; Lopez-Miranda, V.; Vera, G.] URJC Banco Santander, Grp Excelencia Invest, Grp Multidisciplinar Invest & Tratamiento Dolor I, Alcorcon, Spain.
   [Lopez-Miranda, V.; Vera, G.] CSIC, IQM, Unidad Asociada I D I, Madrid, Spain.
C3 Consejo Superior de Investigaciones Cientificas (CSIC); CSIC-UAM -
   Instituto de Investigacion en Ciencias de la Alimentacion (CIAL);
   Autonomous University of Madrid; Consejo Superior de Investigaciones
   Cientificas (CSIC); CSIC-UAM - Instituto de Investigacion en Ciencias de
   la Alimentacion (CIAL); Universidad Rey Juan Carlos; Consejo Superior de
   Investigaciones Cientificas (CSIC); CSIC - Instituto de Quimica Medica
   (IQM)
RP Miguel, M (corresponding author), UAM, CSIC, Inst Invest Ciencias Alimentac CIAL, Madrid, Spain.; Miguel, M (corresponding author), Univ Rey Juan Carlos, Fac Ciencias Salud, Ciencias Basicas Salud, Madrid, Spain.
EM marta.miguel@csic.es
RI Vera, Gema/AAB-1731-2019; Garces-Rimon, Marta/AAD-3050-2021; Uranga,
   Jose/M-4343-2018; Lopez-Miranda, Visitacion/E-1116-2012; MIGUEL CASTRO,
   MARTA/F-6112-2011
OI Uranga, Jose/0000-0003-4656-8569; Lopez-Miranda,
   Visitacion/0000-0003-1378-0387; Moreno-Fernandez,
   Silvia/0000-0002-9316-6477; MIGUEL CASTRO, MARTA/0000-0002-5525-1056;
   Vera Pasamontes, Gema/0000-0002-1838-0975; Garces-Rimon,
   Marta/0000-0002-3888-4150
FU Spanish Ministry of Economy, Industry and Competitiveness (MINECO)
   [AGL2012-32387, BES-2013-065684, 201570I028]
FX Authors would like to acknowledge the financial support of the Spanish
   Ministry of Economy, Industry and Competitiveness (MINECO) (under the
   projects AGL2012-32387 and CSIC - Intramural 201570I028 and under grant
   number BES-2013-065684).
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NR 40
TC 23
Z9 23
U1 2
U2 24
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PD JAN
PY 2018
VL 9
IS 1
BP 78
EP 86
DI 10.1039/c7fo01280b
PG 9
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA FT7RV
UT WOS:000423351400006
PM 29114652
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Zhu, L
   Yang, L
   Liang, ZH
   Shi, W
   Ma, M
   Chen, JB
   Abdula, Z
   Gong, XC
AF Zhu, Li
   Yang, Long
   Liang, Zonghua
   Shi, Wen
   Ma, Ming
   Chen, Jingbo
   Abdula, Zulipikaer
   Gong, Xuchen
TI Association between dietary calcium intake and constipation in a
   metabolic syndrome population: evidence from NHANES 2005-2010
SO FRONTIERS IN NUTRITION
LA English
DT Article
DE metabolic syndrome; calcium; dietary; constipation; NHANES
ID IRRITABLE-BOWEL-SYNDROME; COLORECTAL-CANCER; REPRESENTATIVE SAMPLE;
   GLOBAL PREVALENCE; NATIONAL-HEALTH; RISK-FACTORS; VITAMIN-D; BODY-FAT;
   ADULTS; COLON
AB Background The global prevalence of Metabolic Syndrome (MetS) is increasing, primarily characterized by abdominal obesity, which significantly heightens the risk of cardiovascular diseases, gastrointestinal disorders, and cancers. Constipation is a common gastrointestinal issue that impacts both physiological and psychological health and worsens with age. Calcium, an essential mineral vital for human health, has been proven to be crucial not only for bone health but also beneficial for gastrointestinal health. However, the results regarding its impact on constipation are inconsistent. This study aimed to investigate the relationship between dietary calcium intake and constipation in individuals with MetS.Methods This cross-sectional study utilized data from the National Health and Nutrition Examination Survey (NHANES) from 2005 to 2010. Participants were assessed for MetS based on the International Diabetes Federation (IDF) criteria. Dietary calcium intake was evaluated through 24-h dietary recalls, and constipation was defined based on the frequency of bowel movements recorded in the bowel health questionnaire. The relationship between calcium intake and constipation was explored using logistic regression models with adjustment for covariates, and restricted cubic spline analyses were also used to investigate nonlinear relationships.Results The study included 4,838 adult participants with MetS. Adjusted logistic regression revealed that an increase in dietary calcium intake was significantly associated with a reduced risk of constipation (OR: 0.562, 95% CI: 0.379 to 0.835, p = 0.006). Compared to the lowest quartile, the highest quartile of dietary calcium intake significantly decreased the risk of constipation (OR: 0.282, 95% CI: 0.115 to 0.691, p = 0.008). Results from the restrictive cubic spline analysis indicated a negative linear association between dietary calcium intake and constipation risk (non-linearity p = 0.704).Conclusion The findings suggested that increased dietary calcium intake is associated with a decreased risk of constipation among MetS patients, emphasizing dietary calcium as a potentially modifiable factor for managing gastrointestinal symptoms in this population.
C1 [Zhu, Li; Liang, Zonghua; Shi, Wen; Abdula, Zulipikaer; Gong, Xuchen] Peoples Hosp Xinjiang Uygur Autonomous Reg, Dept Anus & Intestine Surg, Urumqi, Peoples R China.
   [Yang, Long] Xinjiang Med Univ, Affiliated Hosp 1, Pediat Cardiothorac Surg, Urumqi, Peoples R China.
   [Ma, Ming] Peoples Hosp Xinjiang Uygur Autonomous Reg, Res & Educ Ctr, Urumqi, Peoples R China.
   [Chen, Jingbo] Peoples Hosp Xinjiang Uygur Autonomous Reg, Dept Tradit Chinese Med, Urumqi, Peoples R China.
C3 Xinjiang Medical University
RP Zhu, L (corresponding author), Peoples Hosp Xinjiang Uygur Autonomous Reg, Dept Anus & Intestine Surg, Urumqi, Peoples R China.
EM 158096894@qq.com
RI Yang, Long/GWC-6053-2022
OI Yang, Long/0000-0003-1870-878X
FU Xinjiang Uygur Autonomous Region's Natural Science Foundation
   [2022D01C142]; Xinjiang Uygur Autonomous Region Graduate Student
   Innovation Program [XJ2024G167]
FX The author(s) declare that financial support was received for the
   research, authorship, and/or publication of this article. This research
   was supported by the Xinjiang Uygur Autonomous Region's Natural Science
   Foundation (2022D01C142) and the Xinjiang Uygur Autonomous Region
   Graduate Student Innovation Program (XJ2024G167).
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   Zipf George, 2013, Vital Health Stat 1, P1
NR 59
TC 0
Z9 0
U1 3
U2 3
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD OCT 30
PY 2024
VL 11
AR 1422564
DI 10.3389/fnut.2024.1422564
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA L7Y0O
UT WOS:001352830000001
PM 39539369
OA gold
DA 2025-06-11
ER

PT J
AU Kim, S
   Lee, AY
   Kim, HJ
   Hong, SH
   Go, RE
   Choi, KC
   Kang, KS
   Cho, MH
AF Kim, Sanghwa
   Lee, Ah Young
   Kim, Hyeon-Jeong
   Hong, Seong-Ho
   Go, Ryeo-Eun
   Choi, Kyung-Chul
   Kang, Kyung-Sun
   Cho, Myung-Haing
TI Exposure to cigarette smoke disturbs adipokines secretion causing
   intercellular damage and insulin resistance in high fructose diet
   induced metabolic disorder mice
SO BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
LA English
DT Article
DE Cigarette smoke; High fructose diet; Organelle damage; ER stress;
   Adipokines; Insulin resistance
ID ENDOPLASMIC-RETICULUM STRESS; BODY-WEIGHT; ER STRESS; LEPTIN LEVELS;
   PLASMA; CESSATION; OBESITY; INFLAMMATION; ADIPONECTIN; GHRELIN
AB A large amount of fructose intake along with smoking is associated with increased incidence of diseases linked to metabolic syndrome. More research is necessary to understand the complex mechanism that ultimately results in metabolic syndrome and the effect, if any, of high fructose dietary intake and smoking on individual health. In this study, we investigated changes in ER-Golgi network and disturbance to secretion of adipokines induced by cigarette smoking (CS) and excess fructose intake and their contribution to the disruption of metabolic homeostasis. We used high fructose-induced metabolic disorder mice model by feeding them with high fructose diet for 8 weeks. For CS exposure experiment, these mice were exposed to CS for 28 days according to OECD guideline 412. Our results clearly showed that the immune system was suppressed and ER stress was induced in mice with exposure to CS and fed with high fructose. Furthermore, their concentrations of adipokines including leptin and adiponectin were aberrant. Such alteration in secretion of adipokines could cause insulin resistance which may lead to the development of type 2 diabetes. (C) 2017 Elsevier Inc. All rights reserved.
C1 [Kim, Sanghwa] Korea Inst Radiol & Med Sci, Div Basic Radiat Biosci, Seoul 01812, South Korea.
   [Kim, Sanghwa; Lee, Ah Young; Kim, Hyeon-Jeong; Hong, Seong-Ho; Cho, Myung-Haing] Seoul Natl Univ, Coll Vet Med, Lab Toxicol, Seoul 08826, South Korea.
   [Hong, Seong-Ho] CKD Res Inst, Bio Med Lab, Yongin 16995, South Korea.
   [Go, Ryeo-Eun; Choi, Kyung-Chul] Chungbuk Natl Univ, Vet Med Ctr, Lab Biochem & Immunol, Cheongju 28644, Chungbuk, South Korea.
   [Go, Ryeo-Eun; Choi, Kyung-Chul] Chungbuk Natl Univ, Coll Vet Med, Cheongju 28644, Chungbuk, South Korea.
   [Kang, Kyung-Sun] Seoul Natl Univ, Coll Vet Med, Adult Stem Cell Res Ctr, Seoul 08826, South Korea.
   [Cho, Myung-Haing] Seoul Natl Univ, Grad Grp Tumor Biol, Seoul 08826, South Korea.
   [Cho, Myung-Haing] Seoul Natl Univ, Inst GreenBio Sci Technol, Pyeongchang 25354, South Korea.
   [Cho, Myung-Haing] Seoul Natl Univ, Grad Sch Convergence Sci & Technol, Suwon 16229, South Korea.
   [Cho, Myung-Haing] Seoul Natl Univ, Adv Inst Convergence Technol, Suwon 16229, South Korea.
C3 Korea Institute of Radiological & Medical Sciences; Seoul National
   University (SNU); Chungbuk National University; Chungbuk National
   University; Seoul National University (SNU); Seoul National University
   (SNU); Seoul National University (SNU); Seoul National University (SNU);
   Seoul National University (SNU)
RP Cho, MH (corresponding author), Seoul Natl Univ, Coll Vet Med, Lab Toxicol, Seoul 08826, South Korea.
EM mchotox@snu.ac.kr
RI Kang, Kyung-Sun/G-6205-2013; Choi, Kyung-Chul/AHC-2282-2022; Cho,
   Myung-Haing/B-7362-2014
OI Kang, Kyung-Sun/0000-0002-9322-741X; Cho,
   Myung-Haing/0000-0002-3993-2011
FU Ministry of Food and Drug Safety [14182MFDS977]
FX This research was supported by a grant(14182MFDS977) from the Ministry
   of Food and Drug Safety in 2017.
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NR 35
TC 5
Z9 5
U1 0
U2 5
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0006-291X
EI 1090-2104
J9 BIOCHEM BIOPH RES CO
JI Biochem. Biophys. Res. Commun.
PD DEC 16
PY 2017
VL 494
IS 3-4
BP 648
EP 655
DI 10.1016/j.bbrc.2017.10.121
PG 8
WC Biochemistry & Molecular Biology; Biophysics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics
GA FN9WJ
UT WOS:000416393300032
PM 29079192
DA 2025-06-11
ER

PT J
AU Bekyarova, GY
   Bekyarov, NA
   Madjova, VH
   Madjova, CR
   Kalevska, ED
   Salim, AS
   Vankova, DG
   Ivanova, DG
   Kiselova-Kaneva, YD
AF Bekyarova, Ganka Y.
   Bekyarov, Nicolai A.
   Madjova, Valentina H.
   Madjova, Christiana R.
   Kalevska, Evgenia D.
   Salim, Ayshe S.
   Vankova, Deyana G.
   Ivanova, Diana G.
   Kiselova-Kaneva, Yoana D.
TI Age-Associated Changes in Carotid Intima-Media Thickness in Relation to
   Redox Balance Indices in Metabolic Syndrome
SO APPLIED SCIENCES-BASEL
LA English
DT Article
DE biomarkers; metabolic syndrome; carotid intima-media thickness;
   peripheral blood mononuclear cells (PBMCs); gene expression
ID ASYMMETRIC DIMETHYLARGININE ADMA; ENDOTHELIAL DYSFUNCTION; OXIDATIVE
   STRESS; HEME OXYGENASE; ATHEROSCLEROSIS; PREDICTOR; IMPACT; ADULTS;
   CELLS; NRF2
AB Featured Application In this study, we evaluated the relationship among the carotid intima-media thickness (CIMT), the redox balance parameters of plasma asymmetric dimethylarginine (ADMA), malondialdehyde (MDA), and HO-1, and the expression of oxidative stress-related NF-kB, Nrf2, and HO-1 in peripheral blood mononuclear cells as biomarkers in metabolic syndrome (MetS). Abstract Metabolic syndrome (MetS) is defined by the World Health Organisation (WHO) as a pathologic condition characterized by abdominal obesity, insulin resistance, hypertension, and hyperlipidaemia. The components of MetS and the associated cardiovascular risks may disrupt the vascular endothelial function and the structure of the vascular wall, increasing the risk of atherosclerosis and vascular diseases. In this study we evaluated the relationship between the carotid intima-media thickness (CIMT), the redox balance parameters of plasma asymmetric dimethylarginine (ADMA), malondialdehyde (MDA), and heme oxygenase 1 (HO-1), and the expression of oxidative stress-related nuclear factor kappa B (NF-kB), nuclear factor erythroid 2-related factor 2 (Nrf2), and HO-1 in peripheral blood mononuclear cells (PBMCs) in MetS. Significantly higher CIMT was established in MetS patients aged >= 55 years as compared with the control group (0.96 +/- 0.29 vs. 0.74 +/- 0.21, p < 0.05). Expression was higher in MetS patients aged < 55 years (83% for NF-kB, p < 0.05; 251% for Nrf2, p < 0.05, and 337% for HO-1, p < 0.05) in comparison to the control group. Similarly, expression was higher in CIMT < 0.90 mm than the control group by 80% for NF-kB, p < 0.01; 260% for Nrf2, p < 0.05, and 303% for HO-1, p < 0.05. In contrast, gene expression was under-regulated in the subgroups of MetS patients aged >= 55 years and MetS patients with CIMT >= 0.90 mm. Significantly higher plasma levels for MDA, ADMA, and HO-1 were established in the age < 55 and age >= 55 MetS subgroups and the CIMT < 0.90 mm and CIMT >= 0.90 mm subgroups. In conclusion, MetS individuals aged >= 55 are at higher risk of increased CIMT and impaired redox balance.
C1 [Bekyarova, Ganka Y.] Med Univ Varna, Dept Physiol & Pathophysiol, Varna 9002, Bulgaria.
   [Bekyarov, Nicolai A.; Madjova, Valentina H.] Med Univ Varna, Dept Gen Med, Varna 9002, Bulgaria.
   [Madjova, Christiana R.] Med Univ Varna, Dept Conservat Dent Treatment & Oral Pathol, Varna 9002, Bulgaria.
   [Kalevska, Evgenia D.] Med Univ Varna, Dept Neurol & Neurosci, Varna 9002, Bulgaria.
   [Salim, Ayshe S.; Vankova, Deyana G.; Ivanova, Diana G.; Kiselova-Kaneva, Yoana D.] Med Univ Varna, Dept Biochem Mol Med & Nutrigen, Varna 9002, Bulgaria.
C3 Medical University Varna; Medical University Varna; Medical University
   Varna; Medical University Varna; Medical University Varna
RP Kiselova-Kaneva, YD (corresponding author), Med Univ Varna, Dept Biochem Mol Med & Nutrigen, Varna 9002, Bulgaria.
EM ganka.bekyarova@abv.bg; ninobek@abv.bg; valentina.madjova@mu-varna.bg;
   christiana.madjova@mu-varna.bg; kalevska@abv.bg;
   ayshe.salim@mu-varna.bg; deyana.vankova@mu-varna.bg;
   divanova@mu-varna.bg; yoana.kiselova@mu-varna.bg
RI Vankova, Deyana/MZQ-2229-2025; Ivanova, Diana/JVY-8696-2024
FU Union-NextGenerationEU through the National Recovery and Resilience Plan
   of the Republic of Bulgaria [BG-RRP-2.004-0009-C02]; European
   Union-NextGenerationEU through the National Recovery and Resilience Plan
   of the Republic of Bulgaria
FX This study is financed by the European Union-NextGenerationEU through
   the National Recovery and Resilience Plan of the Republic of Bulgaria,
   project No. BG-RRP-2.004-0009-C02, Research group 3.1.1. Natura4Health.
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NR 45
TC 0
Z9 0
U1 1
U2 5
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3417
J9 APPL SCI-BASEL
JI Appl. Sci.-Basel
PD AUG
PY 2024
VL 14
IS 16
AR 7218
DI 10.3390/app14167218
PG 12
WC Chemistry, Multidisciplinary; Engineering, Multidisciplinary; Materials
   Science, Multidisciplinary; Physics, Applied
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Engineering; Materials Science; Physics
GA F1H8Q
UT WOS:001307407800001
OA gold
DA 2025-06-11
ER

PT J
AU Medina, SP
   Kim, RG
   Magee, C
   Stapper, N
   Khalili, M
AF Medina, Sheyla P.
   Kim, Rebecca G.
   Magee, Catherine
   Stapper, Noah
   Khalili, Mandana
TI Cross-sectional study on stigma and motivation to adhere to lifestyle
   modification among vulnerable populations with fatty liver disease
SO OBESITY SCIENCE & PRACTICE
LA English
DT Article
DE alcohol-associated liver disease; behavioral modification; metabolic
   syndrome; NAFLD; underserved populations
ID UNITED-STATES; NONALCOHOLIC STEATOHEPATITIS; WEIGHT-LOSS; HEPATIC
   STEATOSIS; HEALTH; DISPARITIES; PREVALENCE; IMPACT; ADULTS; OVERWEIGHT
AB ObjectivesAdherence to lifestyle modification (diet, exercise, and alcohol cessation) for fatty liver disease (FLD) management remains challenging. The study examined stigma, barriers, and factors associated with motivation to adhere to lifestyle modification in a diverse and vulnerable population with FLD. MethodsFrom 2/19/2020 to 2/28/2022, 249 FLD patients within San Francisco safety-net hepatology clinics were surveyed along with clinical data taken from medical records. Multivariable modeling assessed factors associated with motivation to adhere to lifestyle modification in a cross-sectional study. ResultsMedian age was 53 years, 59% female, 59% Hispanic, 25% Asian/Pacific Islander, 9% White, and 2% Black, 79% were non-English speakers, 64% had & LE; high school education, and 82% reported <$30,000 annual income. Common comorbidities included hyperlipidemia (47%), hypertension (42%), diabetes (39%), and heavy alcohol use (22%). Majority (78%) reported experiencing stigma, 41% reported extreme motivation, and 58% reported & GE; two barriers. When controlling for age, sex, Hispanic ethnicity, alcohol consumption, BMI, >high school (coef 1.41, 95% CI 0.34-2.48), stigma (coef 0.34, 95% CI 0.07-0.62), and depression (coef -1.52, 95% CI -2.79 to -0.26) were associated with motivation. ConclusionsStigma is commonly reported among FLD patients. Interventions to enhance patient education and mental health support are critical to FLD management, especially in vulnerable populations.
C1 [Medina, Sheyla P.; Kim, Rebecca G.; Khalili, Mandana] Univ Calif San Francisco, Dept Med, Div Gastroenterol & Hepatol, San Francisco, CA USA.
   [Magee, Catherine; Stapper, Noah; Khalili, Mandana] Zuckerberg San Francisco Gen, Div Gastroenterol & Hepatol, San Francisco, CA USA.
   [Khalili, Mandana] Univ Calif San Francisco, San Francisco Gen Hosp, San Francisco, CA 94110 USA.
C3 University of California System; University of California San Francisco;
   University of California System; University of California San Francisco;
   San Francisco General Hospital Medical Center
RP Khalili, M (corresponding author), Univ Calif San Francisco, San Francisco Gen Hosp, San Francisco, CA 94110 USA.
EM mandana.khalili@ucsf.edu
OI khalili, mandana/0000-0001-9178-9139; , Rebecca/0000-0001-7965-5760;
   Medina, Sheyla Paola/0000-0002-3095-0379
FU Zuckerberg San Francisco General Hospital Foundation Hearts Grant;
   National Institutes of Health [K24AA022523, T32DK060414, U24MD017250];
   National Institute of Diabetes and Digestive and Kidney Diseases
   [T32DK060414] Funding Source: NIH RePORTER; National Institute on
   Alcohol Abuse and Alcoholism [K24AA022523] Funding Source: NIH RePORTER;
   National Institute on Minority Health and Health Disparities
   [U24MD017250] Funding Source: NIH RePORTER
FX Zuckerberg San Francisco General Hospital Foundation Hearts Grant;
   National Institutes of Health, Grant/Award Numbers: K24AA022523,
   T32DK060414, U24MD017250
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NR 58
TC 6
Z9 6
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2055-2238
J9 OBES SCI PRACT
JI OBES. SCI. PRACT.
PD DEC
PY 2023
VL 9
IS 6
BP 581
EP 589
DI 10.1002/osp4.688
EA JUN 2023
PG 9
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA CB5Q6
UT WOS:001013900900001
PM 38090690
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Basrak, N
   Mulcrone, N
   Sharifuddin, S
   Ghumman, Z
   Bechan, N
   Mohamed, E
   Murray, M
   Rajendran, H
   Gunnigle, S
   Nolan, M
   Quane, T
   Terao, M
   Hoare, T
   Kirrane, K
   Kennedy, HG
   Davoren, M
AF Basrak, Natasa
   Mulcrone, Naoise
   Sharifuddin, Sue
   Ghumman, Zeshan
   Bechan, Nirvana
   Mohamed, Enas
   Murray, Michael
   Rajendran, Hariharan
   Gunnigle, Sean
   Nolan, Mark
   Quane, Tim
   Terao, Masashi
   Hoare, Tracey
   Kirrane, Kevin
   Kennedy, Harry G.
   Davoren, Mary
TI Risk of adverse outcome of COVID-19 among patients in secure psychiatric
   services: observational cohort study
SO BJPSYCH OPEN
LA English
DT Article
DE COVID-19; schizophrenia; forensic mental health services; risk
   assessment; obesity
ID METABOLIC SYNDROME; SCHIZOPHRENIA
AB Background
   Secure forensic mental health services treat patients with high rates of treatment-resistant psychoses. High rates of obesity and medical comorbidities are common. Population-based studies have identified high-risk groups in the event of SARS-CoV-2 infection, including those with problems such as obesity, lung disease and immune-compromising conditions. Structured assessment tools exist to ascertain the risk of adverse outcome in the event of SARS-CoV-2 infection.
   Aims
   To assess risk of adverse outcome in the event of SARS-CoV-2 infection in a complete population of forensic psychiatry patients using structured assessment tools.
   Method
   All patients of a national forensic mental health service (n = 141) were rated for risk of adverse outcome in the event of SARS-CoV-2 infection, using two structured tools, the COVID-Age tool and the COVID-Risk tool.
   Results
   We found high rates of relevant physical comorbidities. Mean chronological age was 45.5 years (s.d. = 11.4, median 44.1), mean score on the COVID-Age tool was 59.1 years (s.d. = 19.4, median 58.0), mean difference was 13.6 years (s.d. = 15.6), paired t = 10.9, d.f. = 140, P < 0.001. Three patients (2.1%) were chronologically over 70 years of age, compared with 43 (30.5%) with a COVID-Age over 70 (chi(2) = 6.99, d.f. = 1, P = 0.008, Fisher's exact test P = 0.027).
   Conclusions
   Patients in secure forensic psychiatric services represent a high-risk group for adverse outcomes in the event of SARS-COV-2 infection. Population-based guidance on self-isolation and other precautions based on chronological age may not be sufficient. There is an urgent need for better physical health research and treatment in this group.
C1 [Basrak, Natasa; Mulcrone, Naoise; Sharifuddin, Sue; Ghumman, Zeshan; Bechan, Nirvana; Mohamed, Enas; Murray, Michael; Rajendran, Hariharan; Gunnigle, Sean; Nolan, Mark; Quane, Tim; Terao, Masashi; Hoare, Tracey; Kirrane, Kevin; Kennedy, Harry G.; Davoren, Mary] Cent Mental Hosp, Natl Forens Mental Hlth Serv, Dublin, Ireland.
   [Nolan, Mark; Davoren, Mary] Trinity Coll Dublin, DUNDRUM Ctr Forens Excellence, Dublin, Ireland.
C3 Trinity College Dublin
RP Davoren, M (corresponding author), Cent Mental Hosp, Natl Forens Mental Hlth Serv, Dublin, Ireland.; Davoren, M (corresponding author), Trinity Coll Dublin, DUNDRUM Ctr Forens Excellence, Dublin, Ireland.
EM davorem@tcd.ie
RI Kennedy, Harry/AAE-6401-2020
OI Davoren, Mary/0000-0002-8054-298X; Kennedy, Harry G/0000-0003-3174-3272
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NR 42
TC 6
Z9 6
U1 1
U2 3
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 2056-4724
J9 BJPSYCH OPEN
JI BJPsych Open
PD JAN 11
PY 2021
VL 7
IS 1
AR e31
DI 10.1192/bjo.2020.169
PG 7
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA PU3YA
UT WOS:000609239600001
PM 33427191
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Mccormick, BP
   Frey, G
   Lee, CT
   Chun, S
   Sibthorp, J
   Gajic, T
   Stamatovic-Gajic, B
   Maksimovich, M
AF Mccormick, Bryan P.
   Frey, Georgia
   Lee, Chien-Tsung
   Chun, Sanghee
   Sibthorp, Jim
   Gajic, Tomislav
   Stamatovic-Gajic, Branka
   Maksimovich, Milena
TI PREDICTING TRANSITORY MOOD FROM PHYSICAL ACTIVITY LEVEL AMONG PEOPLE
   WITH SEVERE MENTAL ILLNESS IN TWO CULTURES
SO INTERNATIONAL JOURNAL OF SOCIAL PSYCHIATRY
LA English
DT Article
DE physical activity; mood; experience sampling; accelerometry
ID METABOLIC SYNDROME; AEROBIC EXERCISE; PSYCHIATRIC REHABILITATION;
   ENERGY-EXPENDITURE; DAILY-LIFE; HEALTH; DEPRESSION; SCHIZOPHRENIA;
   INTERVENTION; INDIVIDUALS
AB Background: Previous studies have indicated that physical activity (PA) is positively related to health-related quality of life and well-being among people with severe mental illness (SMI). Physical activity is broadly defined in this research as any skeletal muscle movement resulting in energy expenditure, including common daily activities such as housework and gardening, as well as walking for transportation and formal exercise. Although the physical health benefits of PA are well documented, evidence suggests that PA provides psychological benefits as well.
   Aims: The purpose of this study was to identify if PA level was associated with transitory mood in the everyday lives of people with SMI across two cultures.
   Methods: Subjects were drawn through mental health centres in Serbia (n = 12) and the USA (n = 11). Data were collected using both experience sampling methodology and accelerometry. Data were analyzed using hierarchical linear modelling.
   Results: Subjects demonstrated low levels of PA, which did not differ significantly between groups. Hierarchical analysis indicated that PA remained significantly positively associated with mood after accounting for individual variation, and this was consistent across groups.
   Conclusions: This study reinforces previous findings that people with SMI demonstrate low PA levels generally. It also supports the consideration of physical activity interventions as a regular part of psychiatric rehabilitation. It appears that increased PA may have the potential to affect both physical health and mood among people with SMI.
C1 [Mccormick, Bryan P.; Lee, Chien-Tsung] Indiana Univ, Dept Kinesiol, Bloomington, IN 47405 USA.
   [Chun, Sanghee] Indiana Univ, Dept Recreat Pk & Tourism Studies, Bloomington, IN 47405 USA.
   [Sibthorp, Jim] Univ Utah, Salt Lake City, UT USA.
   [Gajic, Tomislav; Stamatovic-Gajic, Branka; Maksimovich, Milena] Hlth Ctr Valjevo, Dept Psychiat, Valjevo, Serbia.
C3 Indiana University System; Indiana University Bloomington; Indiana
   University System; Indiana University Bloomington; Utah System of Higher
   Education; University of Utah
RP Mccormick, BP (corresponding author), Indiana Univ, Dept Kinesiol, Bloomington, IN 47405 USA.
EM bmccormi@indiana.edu
RI McCormick, Bryan/AER-1130-2022
OI Sibthorp, Jim/0000-0002-4574-9141
CR [Anonymous], B WHO
   [Anonymous], CLIN EXERCISE PHYSL
   [Anonymous], PHYSL BEHAV
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NR 47
TC 12
Z9 14
U1 0
U2 16
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0020-7640
EI 1741-2854
J9 INT J SOC PSYCHIATR
JI Int. J. Soc. Psychiatr.
PD NOV
PY 2008
VL 54
IS 6
BP 527
EP 538
DI 10.1177/0020764008091423
PG 12
WC Psychiatry
WE Social Science Citation Index (SSCI)
SC Psychiatry
GA 380VC
UT WOS:000261493000006
PM 18974191
DA 2025-06-11
ER

PT J
AU Lin, CH
   Chiang, SL
   Tzeng, WC
   Chiang, LC
AF Lin, Chia-Huei
   Chiang, Shang-Lin
   Tzeng, Wen-Chii
   Chiang, Li-Chi
TI Systematic Review of Impact of Lifestyle-Modification Programs on
   Metabolic Risks and Patient-Reported Outcomes in Adults With Metabolic
   Syndrome
SO WORLDVIEWS ON EVIDENCE-BASED NURSING
LA English
DT Review
DE lifestyle-modification program; metabolic risks; metabolic syndrome;
   patient-reported outcome; quality of life; systematic review
ID QUALITY-OF-LIFE; CARDIOVASCULAR-DISEASE; INTERVENTION; EXERCISE; TRIAL;
   METAANALYSIS; HYPERTENSION; MANAGEMENT
AB Background: Metabolic syndrome (MetS) is primarily attributed to an unhealthy lifestyle, which is a modifiable risk factor. Researchers have been exploring various strategies, including lifestyle-modification programs (LMPs), to prevent the progression of MetS. However, the effectiveness of LMPs on metabolic risks and patient-reported outcomes (PROs) among adults with MetS remains inconclusive.
   Aim: To evaluate the effectiveness of LMPs on the metabolic risks and PROs among adults with MetS.
   Methods: A systematic review of randomized controlled trials published from January 1985 to June 2014 was conducted. The review extracted LMP interventions that included outcomes on the metabolic risks and PROs (quality of life and any other psychological health indicators). The quality of the included studies was assessed using the Cochrane Collaboration criteria.
   Results: Among the five trials included, the most commonly applied intervention components were diet plans, supervised exercise, health education, individual counseling, behavioral modification, and motivational interviewing. Three fifths of the studies were nurse-led, and only one of the selected trials was theory-guided. LMPs can effectively reduce triglyceride levels, waist circumference, and systolic blood pressure. However, few trials consistently confirmed the benefits of metabolic risks, and none revealed a significant effect on high-density lipoprotein, fasting blood glucose, or any PRO, except quality of life. The duration of LMPs in the included trials ranged from 4 to 24 weeks, and durations of at least 12 weeks significantly improved quality of life.
   Linking Evidence to Action: LMPs had positive effects on some metabolic risks and on quality of life, whereas longer-duration LMPs may have highly beneficial effects on quality of life. The essential elements of LMPs need to be evaluated more thoroughly to determine their effectiveness. Larger and more rigorous randomized controlled trials are required to assess the effectiveness of LMPs on metabolic risks and PROs among adults with MetS.
C1 [Lin, Chia-Huei] Natl Def Med Ctr, Grad Inst Med Sci, Taipei, Taiwan.
   [Lin, Chia-Huei; Chiang, Li-Chi] Natl Def Med Ctr, Sch Nursing, Taipei, Taiwan.
   [Lin, Chia-Huei] Tri Serv Gen Hosp, Dept Nursing, Taipei, Taiwan.
   [Chiang, Shang-Lin] Tri Serv Gen Hosp, Dept Phys Med & Rehabil, Taipei, Taiwan.
   [Chiang, Shang-Lin] Natl Yang Ming Univ, Taipei 112, Taiwan.
   [Tzeng, Wen-Chii] Tri Serv Gen Hosp, Dept Nursing, Taipei, Taiwan.
   [Tzeng, Wen-Chii] Natl Def Med Ctr, Taipei, Taiwan.
   [Chiang, Li-Chi] China Med Univ, Sch Nursing, Taichung, Taiwan.
C3 National Defense Medical Center; National Defense Medical Center;
   Tri-Service General Hospital; Tri-Service General Hospital; National
   Yang Ming Chiao Tung University; Tri-Service General Hospital; National
   Defense Medical Center; China Medical University Taiwan
RP Chiang, LC (corresponding author), 161,Sec 6,Minquan E Rd, Taipei 114, Taiwan.
EM lichichiang@gmail.com
RI Lin, Chia-Huei/GLQ-5499-2022; Chiang, Li-Chi/AAW-9661-2020; Tzeng,
   Wen-Chii/M-4214-2014
OI Chiang, Li-Chi/0000-0002-6383-7495; Tzeng, Wen-Chii/0000-0002-4205-896X;
   Lin, Chia-Huei/0000-0003-3751-602X; Lin, Chia-Huei/0000-0002-5557-9668
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NR 28
TC 47
Z9 55
U1 0
U2 25
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1545-102X
EI 1741-6787
J9 WORLDV EVID-BASED NU
JI Worldviews Evid.-Based Nurs.
PD DEC
PY 2014
VL 11
IS 6
BP 361
EP 368
DI 10.1111/wvn.12069
PG 8
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA AW1FH
UT WOS:000346035300003
PM 25488565
DA 2025-06-11
ER

PT J
AU Partsernyak, AS
   Polyakova, VO
   Trufanov, AG
   Medvedev, DS
   Trotsyuk, DV
   Markin, K
   Kurasov, ES
   Kuznetsova, EV
   Krasichkov, AS
AF Partsernyak, Alexander S.
   Polyakova, Victoria O.
   Trufanov, Artem G.
   Medvedev, Dmitriy S.
   Trotsyuk, Dina V.
   Markin, Kirill
   Kurasov, Evgeniy S.
   Kuznetsova, Evgeniya V.
   Krasichkov, Alexander S.
TI Melatonin: Manager of psychosomatic and metabolic disorders in
   polymorbid cardiovascular pathology
SO FRONTIERS IN NEUROSCIENCE
LA English
DT Article
DE melatonin; circadian rhythms; metabolic syndrome; polymorbidity;
   cardiovascular pathology; anxiety and depressive disorders; young men;
   glucose
ID BLOOD-PRESSURE; MYOCARDIAL-INFARCTION; INSULIN SENSITIVITY; SLEEP;
   LEPTIN; RESISTANCE; HEART; NIGHT; CARDIOPROTECTION; DISEASE
AB ObjectivesTo investigate the relationship between changes in circadian patterns of melatonin and clinical manifestations of polymorbid cardiovascular pathology (PCVP) in young men and to analyze the effectiveness of their complex treatment. Materials and methodsWe made the immunohistochemical (IHC) analysis of epiphysis tissues from autopsies of 25 men aged 32-44 with PCVP and metabolic syndrome (MS) who had died as a result of ischemic cardiomyopathy (IC) and 25 persons after the car accident as a control group. Then, 93 young men aged 35-44 with PCVP, metabolic syndrome, and depressive spectrum disorders (DSD) were divided into three groups: (1) standard therapy; (2) standard therapy and psychotherapy sessions; (3) standard therapy in combination with psychotherapeutic and psychophysiological visual and auditory correction sessions. The control group included 24 conditionally healthy male volunteers. Before and after the treatment, we studied the anthropometric status, lipid and carbohydrate metabolism indicators, the level of urinary 6-hydroxymelatonin sulfate, the degree of nocturnal decrease in blood pressure (BP), and the relationship of these indicators with circadian variations of melatonin excretion. ResultsYoung polymorbid patients who died from IC have a lower expression of melatonin type 1 and 2 receptors. All patients with PCVP showed a decrease in the nocturnal melatonin excretion fraction and a correlation with higher severity of depressive (r = -0.72) and anxiety (r = -0.66) symptoms. Reduced values of the 6-hydroxymelatonin sulfate (6-SM) in the 1st (r = 0.45), 2nd (r = 0.39), and 3rd (r = 0.51) groups before treatment was associated with periods of increased BP. The achievement of melatonin excretion reference values and normalization of biochemical parameters of carbohydrate and lipid metabolism, daily BP profile, and psychophysiological state were noted in all three patients' groups, with a more pronounced effect in group 3. ConclusionLow nocturnal melatonin excretion levels are associated with greater severity of clinical symptoms and a higher risk of death in patients with PCVP. Therefore, comprehensive therapy may be more effective for correcting this disease.
C1 [Partsernyak, Alexander S.] Kirov Mil Med Acad, Dept Mil Field Therapy, St Petersburg, Russia.
   [Polyakova, Victoria O.] St Petersburg Res Inst Phthisiopulmonol, Ctr Mol Biomed, St Petersburg, Russia.
   [Trufanov, Artem G.] Kirov Mil Med Acad, Dept Neurol, St Petersburg, Russia.
   [Trufanov, Artem G.] St Petersburg Electrotech Univ LETI, Dept Software Engn & Comp Applicat, St Petersburg, Russia.
   [Medvedev, Dmitriy S.] Fed Med Biol Agcy Russia, Dept Physiol Assessment & Med Correct, Res Inst Hyg Occupat Pathol & Human Ecol, Kuzmolovsky, Russia.
   [Trotsyuk, Dina V.] St Petersburg Med & Social Inst, Dept Internal Dis, Private Educ Inst Higher Educ, St Petersburg, Russia.
   [Markin, Kirill; Kurasov, Evgeniy S.] Kirov Mil Med Acad, Dept Psychiat, St Petersburg, Russia.
   [Kuznetsova, Evgeniya V.] Kirov Mil Med Acad, Dept Med Supply, St Petersburg, Russia.
   [Krasichkov, Alexander S.] St Petersburg Electrotech Univ LETI, Dept Radio Engn Syst, St Petersburg, Russia.
C3 St. Petersburg State Research Institute of Phthisiopulmonology; Saint
   Petersburg State Electrotechnical University; Saint Petersburg State
   Electrotechnical University
RP Partsernyak, AS (corresponding author), Kirov Mil Med Acad, Dept Mil Field Therapy, St Petersburg, Russia.
EM partsernyak@mail.ru
RI Markin, Kirill/AAX-2975-2021; Medvedev, Dmitry/D-4986-2017; Partsernyak,
   Alexander/LWK-1525-2024; Trufanov, Artem/W-2584-2017
OI Markin, Kirill/0000-0002-6242-1279
FU Development Program of ETU LETI;  [075-15-2021-1318]
FX Funding This research was funded by the Development Program of ETU LETI
   within the framework of the program of Strategic Academic Leadership
   Priority-2030 No. 075-15-2021-1318 on 29 September 2021.
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NR 65
TC 0
Z9 0
U1 0
U2 8
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1662-453X
J9 FRONT NEUROSCI-SWITZ
JI Front. Neurosci.
PD SEP 28
PY 2022
VL 16
AR 989497
DI 10.3389/fnins.2022.989497
PG 11
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 5I3TR
UT WOS:000868283800001
PM 36248667
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Herr, RM
   Barrech, A
   Gündel, H
   Lang, J
   Quinete, NS
   Angerer, P
   Li, J
AF Herr, Raphael M.
   Barrech, Amira
   Guendel, Harald
   Lang, Jessica
   Quinete, Natalia Soares
   Angerer, Peter
   Li, Jian
TI Effects of psychosocial work characteristics on hair cortisol - findings
   from a post-trial study
SO STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS
LA English
DT Article
DE Work stress; effort-reward imbalance; change; longitudinal; hair
   cortisol; job security
ID EFFORT-REWARD-IMBALANCE; BODY-MASS INDEX; CORONARY-HEART-DISEASE;
   METABOLIC SYNDROME; CHRONIC STRESS; MENTAL-HEALTH; SALIVARY CORTISOL;
   FUTURE-DIRECTIONS; BLOOD-PRESSURE; JOB STRAIN
AB Prolonged work stress, as indicated by the effort-reward imbalance (ERI) model, jeopardizes health. Cortisol represents a candidate mechanism connecting stress to ill health. However, previous findings appear inconclusive, and recommendations were made to assess work stress at multiple time points and also to investigate ERI (sub-)components. This study therefore examines the effects of two single time points, as well as the mean and change scores between time points of ERI and its components on hair cortisol concentration (HCC), a long-term cortisol measurement. Participants were 66 male factory workers (age: 40.68 +/- 6.74years; HCC: 9.007.11pg/mg), who were followed up after a stress management intervention (2006-2008). In 2008 (T1) and 2015 (T2), participants completed a 23-item ERI questionnaire, assessing effort, the three reward components (esteem, job security, job promotion) and over-commitment. In 2015, participants also provided a 3-cm hair segment close to the scalp for HCC analysis, as well as information on relevant confounders (i.e. medication intake, age, work characteristics, socioeconomic and lifestyle factors, number of stressful life events). Linear regressions revealed hardly any cross-sectional or longitudinal effect of ERI and its components on HCC. Only the change scores between T1 and T2 of job security were negatively associated with lower HCC in unadjusted (beta = -.320; p=.009) and adjusted (beta =-.288; p=.044) models. In this study, only a decrease of perceived job security over time was significantly associated with higher HCC, and other predictors were not related to this outcome. Especially after correction for multiple testing, this study revealed just a weak association of different psychosocial
   Lay summary
   This study showed that an increase in perceived job insecurity is correlated with higher levels of the stress hormone cortisol. The higher levels of cortisol might represent a biological explanation for the negative health effects of job insecurity. The association was, however, relatively low, and more and more voices are questioning whether cortisol in hair is a reliable marker for perceived work stress.work measurements with HCC.
C1 [Herr, Raphael M.; Barrech, Amira; Angerer, Peter; Li, Jian] Heinrich Heine Univ Dusseldorf, Fac Med, Ctr Hlth & Soc, Inst Occupat Social & Environm Med, Univ Str 1, D-40225 Dusseldorf, Germany.
   [Herr, Raphael M.] Heidelberg Univ, Med Fac Mannheim, Mannheim Inst Publ Hlth Social & Prevent Med, Mannheim, Germany.
   [Barrech, Amira; Guendel, Harald] Univ Ulm, Dept Psychosomat Med, Ulm, Germany.
   [Lang, Jessica; Quinete, Natalia Soares] Rhein Westfal TH Aachen, Inst Occupat & Social Med, Aachen, Germany.
C3 Heinrich Heine University Dusseldorf; Ruprecht Karls University
   Heidelberg; Ulm University; RWTH Aachen University
RP Herr, RM (corresponding author), Heinrich Heine Univ Dusseldorf, Fac Med, Ctr Hlth & Soc, Inst Occupat Social & Environm Med, Univ Str 1, D-40225 Dusseldorf, Germany.
EM raphael.herr@medma.uni-heidelberg.de
RI Gündel, Harald/AAZ-2905-2020; Herr, Raphael/GYU-5115-2022; Soares
   Quinete, Natalia/J-5100-2014
OI Soares Quinete, Natalia/0000-0001-9486-2995
FU German Federal Ministry of Education and Research (BMBF) [01EL1409B]
FX This work was supported by the German Federal Ministry of Education and
   Research (BMBF) under Grant No. 01EL1409B.
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NR 58
TC 11
Z9 13
U1 0
U2 19
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1025-3890
EI 1607-8888
J9 STRESS
JI Stress
PY 2017
VL 20
IS 4
BP 363
EP 370
DI 10.1080/10253890.2017.1340452
PG 8
WC Behavioral Sciences; Endocrinology & Metabolism; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Behavioral Sciences; Endocrinology & Metabolism; Neurosciences &
   Neurology
GA FA6TE
UT WOS:000405576300005
PM 28595512
DA 2025-06-11
ER

PT J
AU Dutt, S
   Roul, P
   Yang, YYA
   Johnson, TM
   Michaud, K
   Sauer, B
   Cannon, GW
   Baker, JF
   Curtis, JR
   Mikuls, TR
   England, BR
AF Dutt, Sarah
   Roul, Punyasha
   Yang, Yangyuna
   Johnson, Tate M.
   Michaud, Kaleb
   Sauer, Brian
   Cannon, Grant W.
   Baker, Joshua F.
   Curtis, Jeffrey R.
   Mikuls, Ted R.
   England, Bryant R.
TI Multimorbidity Patterns and Rheumatoid Arthritis Disease Outcomes:
   Findings From a Multicenter, Prospective Cohort
SO ARTHRITIS CARE & RESEARCH
LA English
DT Article
ID METABOLIC SYNDROME; REMISSION; IMPACT
AB Objective. To determine whether unique multimorbidity patterns are associated with long-term rheumatoid arthritis (RA) disease severity.
   Methods. We conducted a cohort study within the Veterans Affairs Rheumatoid Arthritis registry. We applied previously derived multimorbidity patterns based on the presence of diagnostic codes for relevant conditions prior to enrollment using linked administrative data. Disease activity and functional status were assessed longitudinally up to 5 years after enrollment. The association of multimorbidity patterns with disease activity and functional status were assessed using generalized estimating equations models adjusting for relevant confounders.
   Results. We studied 2,956 participants, of which 88.2% were male, 76.9% reported white race, and 79.3% had a smoking history. Mental health and substance abuse (beta 0.12 [95% confidence interval {CI} 0.00, 0.23]), cardiovascular (beta 0.25 [95% CI 0.12, 0.38]), and chronic pain (beta 0.21 [95% CI 0.11, 0.31]) multimorbidity were associated with higher Disease Activity Score in 28 joints (DAS28) scores. Mental health and substance abuse (beta 0.09 [0.03, 0.15]), cardiovascular (beta 0.11 [95% CI 0.04, 0.17]), and chronic pain multimorbidity (beta 0.15 [95% CI 0.10, 0.20]) were also associated with higher Multidimensional Health Assessment Questionnaire (MDHAQ) scores. The metabolic pattern of multimorbidity was not associated with DAS28 or MDHAQ. The number of multimorbidity patterns present was highly associated with DAS28 and MDHAQ (P trend < 0.001), and patients with all four multimorbidity patterns had the highest DAS28 (beta 0.59 [95% CI 0.36, 0.83]) and MDHAQ (beta 0.27 [95% CI 0.16, 0.39]) scores.
   Conclusion. Mental health and substance abuse, chronic pain, and cardiovascular multimorbidity patterns are associated with increased RA disease activity and poorer functional status. Identifying and addressing these multimorbidity patterns may facilitate achieving RA treatment targets.
C1 [Dutt, Sarah; Roul, Punyasha; Yang, Yangyuna; Johnson, Tate M.; Mikuls, Ted R.; England, Bryant R.] VA Nebraska Western Iowa Hlth Care Syst, Omaha, NE 68105 USA.
   [Dutt, Sarah; Roul, Punyasha; Yang, Yangyuna; Johnson, Tate M.; Michaud, Kaleb; Mikuls, Ted R.; England, Bryant R.] Univ Nebraska Med Ctr, Omaha, NE 68198 USA.
   [Michaud, Kaleb] FORWARD Natl Data Bank Rheumat Dis, Wichita, KS USA.
   [Sauer, Brian; Cannon, Grant W.] VA Salt Lake City, Salt Lake City, UT USA.
   [Sauer, Brian; Cannon, Grant W.] Univ Utah, Salt Lake City, UT USA.
   [Baker, Joshua F.] Corporal Michael J Crescenz VA Med Ctr, Philadelphia, PA USA.
   [Baker, Joshua F.] Univ Penn, Philadelphia, PA USA.
   [Curtis, Jeffrey R.] Univ Alabama Birmingham, Birmingham, AL USA.
C3 US Department of Veterans Affairs; Veterans Health Administration (VHA);
   VA Nebraska-Western Iowa Health Care System; University of Nebraska
   System; University of Nebraska Medical Center; US Department of Veterans
   Affairs; Utah System of Higher Education; University of Utah; University
   of Pennsylvania; University of Alabama System; University of Alabama
   Birmingham
RP England, BR (corresponding author), VA Nebraska Western Iowa Hlth Care Syst, Omaha, NE 68105 USA.; England, BR (corresponding author), Univ Nebraska Med Ctr, Omaha, NE 68198 USA.
EM Bryant.england@unmc.edu
RI Michaud, Kaleb/AAG-3708-2020; England, Bryant/AAH-6545-2020; Curtis,
   Jeffrey/I-6723-2015; Roul, Punyasha/HJO-8788-2023; Yang,
   Yangyuna/KHW-5963-2024; Sauer, Brian/C-2548-2014
OI Sauer, Brian/0000-0002-3546-3051; Mikuls, Ted/0000-0002-0897-2272;
   Johnson, Tate/0000-0003-0335-4157; Cannon, Grant/0000-0001-6640-9173;
   Michaud, Kaleb/0000-0002-5350-3934
FU Rheumatology Research Foundation Scientist Development award; VAMerit
   Award [CX-001703]; NIH/National Institute of Arthritis and
   Musculoskeletal and Skin Diseases [P30-AR-072583]; Patient Centered
   Outcomes Research Institute; VA Merit Award [BX-004600]; Department of
   Defense [PR-200793]; NIH/National Institute of General Medical Sciences
   [IK2-CX-002203]; VA Clinical Science Research Development; 
   [U54-GM-115458]
FX Dr. Johnson's work was supported by a Rheumatology Research Foundation
   Scientist Development award. Dr. Baker's work was supported by a VAMerit
   Award (grant CX-001703). Dr. Curtis's work was supported by the
   NIH/National Institute of Arthritis and Musculoskeletal and Skin
   Diseases grant P30-AR-072583) and the Patient Centered Outcomes Research
   Institute. Dr. Mikuls's work was supported by a VA Merit Award (grant
   BX-004600), the Department of Defense (grant PR-200793) and the
   NIH/National Institute of General Medical Sciences (grant
   U54-GM-115458).Dr. England's work was supported by a Rheumatology
   Research Foundation Scientist Development award, the Great Plains
   IDeA-CTR from the NIH/National Institute of General Medical Sciences
   (grant U54-GM-115458),and the VA Clinical Science Research & Development
   (grant IK2-CX-002203).
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NR 30
TC 4
Z9 4
U1 2
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2151-464X
EI 2151-4658
J9 ARTHRIT CARE RES
JI Arthritis Care Res.
PD MAR
PY 2025
VL 77
IS 3
BP 337
EP 348
DI 10.1002/acr.25184
EA OCT 2023
PG 12
WC Rheumatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Rheumatology
GA 1OW3O
UT WOS:001094022800001
PM 37394710
OA hybrid, Green Accepted
DA 2025-06-11
ER

PT J
AU Cruthirds, CL
   van der Meij, BS
   Wierzchowska-McNew, A
   Deutz, NEP
   Engelen, MPKJ
AF Cruthirds, Clayton L.
   van der Meij, Barbara S.
   Wierzchowska-McNew, Agata
   Deutz, Nicolaas E. P.
   Engelen, Marielle P. K. J.
TI Presence or Absence of Skeletal Muscle Dysfunction in Chronic
   Obstructive Pulmonary Disease is Associated With Distinct Phenotypes
SO ARCHIVOS DE BRONCONEUMOLOGIA
LA English
DT Article
DE COPD; Muscle strength; Cognition; Phenotype; Metabolism
ID COGNITIVE FUNCTION; SYSTEMIC INFLAMMATION; OXIDATIVE STRESS; STRENGTH;
   REHABILITATION; IMPAIRMENT; METABOLISM; EXERCISE; DECLINE; UPDATE
AB Introduction: Reduced skeletal muscle function and cognitive performance are common extrapulmonary features in Chronic Obstructive Pulmonary Disease (COPD) but their connection remains unclear. Whether presence or absence of skeletal muscle dysfunction in COPD patients is linked to a specific phenotype consisting of reduced cognitive performance, comorbidities and nutritional and metabolic disturbances needs further investigation.
   Methods: Thirty-seven patients with COPD (grade II-IV) were divided into two phenotypic cohorts based on the presence (COPD dysfunctional, n = 25) or absence (COPD functional, n = 12) of muscle dysfunction. These cohorts were compared to 28 healthy, age matched controls. Muscle strength (dynamometry), cognitive performance (Trail Making Test and STROOP Test), body composition (Dual-energy X-Ray Absorptiometry), habitual physical activity, comorbidities and mood status (questionnaires) were measured. Pulse administration of stable amino acid tracers was performed to measure whole body production rates.
   Results: Presence of muscle dysfunction in COPD was independent of muscle mass or severity of airflow obstruction but associated with impaired STROOP Test performance (p = 0.04), reduced resting O-2 saturation (p = 0.003) and physical inactivity (p = 0.01), and specific amino acid metabolic disturbances (enhanced leucine (p = 0.02) and arginine (p = 0.06) production). In contrast, COPD patients with normal muscle function presented with anxiety, increased fat mass, plasma glucose concentration, and metabolic syndrome related comorbidities (hypertension and dyslipidemia).
   Conclusion: COPD patients with muscle dysfunction show characteristics of a cognitive metabolic impairment phenotype, influenced by the presence of hypoxia, whereas those with normal muscle function present a phenotype of metabolic syndrome and mood disturbances.
   (C) 2020 SEPAR. Published by Elsevier Espanna, S.L.U. All rights reserved.
C1 [Cruthirds, Clayton L.; van der Meij, Barbara S.; Wierzchowska-McNew, Agata; Deutz, Nicolaas E. P.; Engelen, Marielle P. K. J.] Texas A&M Univ, Ctr Translat Res Aging & Longev, Dept Hlth & Kinesiol, College Stn, TX 77843 USA.
   [van der Meij, Barbara S.] Bond Univ, Nutr & Dietet Res Grp, Fac Hlth Sci & Med, Gold Coast, Qld, Australia.
   [van der Meij, Barbara S.] Mater Grp, Dietet & Foodserv, Brisbane, Qld, Australia.
   [van der Meij, Barbara S.] Univ Queensland, Mater Res Inst, Brisbane, Qld, Australia.
C3 Texas A&M University System; Texas A&M University College Station; Bond
   University; University of Queensland; Mater Research
RP Engelen, MPKJ (corresponding author), Texas A&M Univ, Ctr Translat Res Aging & Longev, Dept Hlth & Kinesiol, College Stn, TX 77843 USA.
EM mpkj.engelen@ctral.org
RI van der Meij, Barbara/ABD-1824-2020; Deutz, Nicolaas/J-5200-2012
OI McNew, Raven A/0000-0003-2374-1664
CR Alfaro-Acha A, 2006, J GERONTOL A-BIOL, V61, P859, DOI 10.1093/gerona/61.8.859
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NR 40
TC 15
Z9 16
U1 0
U2 23
PU ELSEVIER ESPANA SLU
PI BARCELONA
PA AV JOSEP TARRADELLAS, 20-30, 1ERA PLANTA, BARCELONA, CP-08029, SPAIN
SN 0300-2896
EI 1579-2129
J9 ARCH BRONCONEUMOL
JI Arch. Bronconeumol.
PD APR
PY 2021
VL 57
IS 4
BP 264
EP 272
DI 10.1016/j.arbres.2019.12.034
EA APR 2021
PG 9
WC Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Respiratory System
GA RP3CI
UT WOS:000641609500009
PM 32115277
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Ajiboye, TO
   Aliyu, H
   Tanimu, MA
   Muhammad, RM
   Ibitoye, OB
AF Ajiboye, T. O.
   Aliyu, H.
   Tanimu, M. A.
   Muhammad, R. M.
   Ibitoye, O. B.
TI Dioscoreophyllum cumminsii (Stapf) Diels leaves halt
   high-fructose induced metabolic syndrome: Hyperglycemia, insulin
   resistance, inflammation and oxidative stress
SO JOURNAL OF ETHNOPHARMACOLOGY
LA English
DT Article
DE Dioscoreophyllum cumminsii; Insulin resistance; Dyslipidemia;
   High-fructose diet; Metabolic syndrome; Inflammation; Oxidative stress
ID ADIPOSE-TISSUE; ANTIOXIDANT; CHOLESTEROL; SENSITIVITY; EXPRESSION;
   EXTRACT; ENZYME
AB Ethnopharmacological relevance: Dioscoreophyllum cumminsii is widely used in the management and treatment of diabetes and obesity in Nigeria. This study evaluates the effect of aqueous leaf extract of D. cumminsii on high-fructose diet-induced metabolic syndrome.
   Methods: Seventy male rats were randomized into seven groups. All rats were fed with high-fructose diet for 9 weeks except groups A and C rats, which received control diet. In addition to the diet treatment, groups A and B rats received distilled water for 3 weeks starting from the seventh week of the experimental period. Rats in groups C-F orally received 400, 100, 200 and 400 mg/kg body weight of aqueous leaf extract of D. cumminsii respectively, while group G received 300 mg/kg bodyweight of metformin for 3 weeks starting from the seventh week.
   Results: There was significant (p < 0.05) reduction in high-fructose diet-mediated increase in body weight, body mass index, abdominal circumference, blood glucose, insulin, leptin and insulin resistance by aqueous leaf extract of D. cumminsii. Conversely, high-fructose diet-mediated decrease in adiponectin was reversed by the extract. Increased levels of cholesterol, triglycerides, low-density lipoprotein cholesterol, very low-density lipoprotein cholesterol, atherogenic index, cardiac index and coronary artery index were significantly lowered by the extract, while high-fructose diet mediated decrease in high density lipoprotein cholesterol was increased by the extract. Tumour necrosis factor-alpha, interleukin-6 and interleukin-8 levels increased significantly in high-fructose diet-fed rats, which were significantly reversed by the extract. High-fructose mediated-decrease in superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, glucose 6-phosphate dehydrogenase and glutathione reduced were significantly reversed by aqueous leaf extract of D. cumminsii. Conversely, elevated levels of malondialdehyde, conjugated dienes, lipid hydroperoxides, protein carbonyl and fragmented DNA were significantly lowered by the extract.
   Conclusion: Data generated in this study further laid credence to the hypoglycemic activity of aqueous leaf extract of D. cumminsii as evident from the reversal of hyperglycemia, insulin resistance, dyslipidemia, inflammation and oxidative stress in high-fructose diet-induced metabolic syndrome rats. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
C1 [Ajiboye, T. O.; Aliyu, H.; Tanimu, M. A.; Muhammad, R. M.; Ibitoye, O. B.] Al Hikmah Univ, Dept Biol Sci, Antioxidants Free Radicals Funct Foods & Toxicol, Ilorin, Nigeria.
RP Ajiboye, TO (corresponding author), Al Hikmah Univ, Dept Biol Sci, Antioxidants Free Radicals Funct Foods & Toxicol, Ilorin, Nigeria.
EM ajiboyeyong@yahoo.com
RI Ajiboye, Taofeek/H-5383-2011
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NR 47
TC 25
Z9 25
U1 0
U2 5
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0378-8741
EI 1872-7573
J9 J ETHNOPHARMACOL
JI J. Ethnopharmacol.
PD NOV 4
PY 2016
VL 192
BP 471
EP 479
DI 10.1016/j.jep.2016.08.024
PG 9
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA EB2LF
UT WOS:000387193000048
PM 27568876
DA 2025-06-11
ER

PT J
AU Urquiaga, I
   D'Acuña, S
   Pérez, D
   Dicenta, S
   Echeverría, G
   Rigotti, A
   Leighton, F
AF Urquiaga, Ines
   D'Acuna, Sonia
   Perez, Druso
   Dicenta, Sara
   Echeverria, Guadalupe
   Rigotti, Attilio
   Leighton, Federico
TI Wine grape pomace flour improves blood pressure, fasting glucose and
   protein damage in humans: a randomized controlled trial
SO BIOLOGICAL RESEARCH
LA English
DT Article
DE Antioxidant; Dietary intervention; Fiber; Metabolic syndrome; Oxidative
   stress; Wine grape pomace
ID POSTPRANDIAL OXIDATIVE STRESS; PLASMA ANTIOXIDANT CAPACITY;
   CORONARY-HEART-DISEASE; DIETARY FIBER INTAKE; RED WINE;
   CARDIOVASCULAR-DISEASE; COLONIC FERMENTATION; MEDITERRANEAN DIET;
   METAANALYSIS; INDIVIDUALS
AB Background: The Mediterranean diet is a healthy diet with positive scientific evidence of preventing chronic diseases. Bioactive components support the healthy properties of the Mediterranean diet. Antioxidants and fiber, two components of the Mediterranean diet, are key functional nutrients for healthy eating and nutrition. Wine grape pomace is a rich source of these dietary constituents and may be beneficial for human health. Our hypothesis was that the intake of red wine grape pomace flour (WGPF) prepared from red wine grapes (Cabernet Sauvignon variety) reduced the metabolic syndrome in humans. To evaluate the effect of WGPF on components of metabolic syndrome we design a 16-week longitudinal intervention study. Thirty-eight males, 30-65 years of age, with at least one component of metabolic syndrome, were randomly assigned to either the intervention group (n = 25) or the control group (n = 13). At lunch, the intervention group was given 20 g of WGPF per day, which contained 10 g of dietary fiber, 822 mg of polyphenols and an antioxidant capacity of 7258 ORAC units. Both groups were asked to maintain their regular eating habits and lifestyles. Clinical evaluation, anthropometric measurements and biochemical blood analyses were done at the beginning and the end of the study.
   Results: WGPF intake significantly decreased systolic and diastolic blood pressure as well as fasting glucose levels. Plasma.-tocopherol and d-tocopherol increased and carbonyl group in plasma protein decreased in WGPT group, significantly. No significant effect was observed for waist circumference, HDL cholesterol, triglycerides, total antioxidant capacity and vitamin C in and between groups. The group-dependent magnitude of the differences between the baseline and final postprandial insulin values and.-tocopherol concentrations was statistically significant.
   Conclusions: The consumption of WGPF-rich in fiber and polyphenol antioxidants, as a food supplement in a regular diet improves blood pressure, glycaemia and postprandial insulin. In addition, increased antioxidant defenses and decreased oxidative protein damage indicating attenuation of oxidative stress. WGPF might be a useful food ingredient for health promotion and chronic disease prevention.
C1 [Urquiaga, Ines; D'Acuna, Sonia; Perez, Druso; Dicenta, Sara; Echeverria, Guadalupe; Rigotti, Attilio; Leighton, Federico] Pontificia Univ Catolica Chile, Ctr Nutr Mol & Enfermedades Cron, Fac Med, Santiago, Chile.
   [Rigotti, Attilio] Pontificia Univ Catolica Chile, Dept Nutr Diabet & Metab, Escuela Med, Santiago, Chile.
C3 Pontificia Universidad Catolica de Chile; Pontificia Universidad
   Catolica de Chile
RP Urquiaga, I (corresponding author), Pontificia Univ Catolica Chile, Ctr Nutr Mol & Enfermedades Cron, Fac Med, Ave Libertador Bernardo OHiggins 340, Santiago, Chile.
EM iurquiaga@bio.puc.cl
RI Echeverría, Guadalupe/GWV-3832-2022
OI Echeverria, Guadalupe/0000-0002-2915-0171
FU FONDEF (Chile) [AF10i1014]
FX Supported by a grant from FONDEF AF10i1014 (Chile).
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NR 51
TC 88
Z9 93
U1 0
U2 78
PU SOC BIOLGIA CHILE
PI SANTIAGO
PA CASILLA 16164, SANTIAGO 9, CHILE
SN 0716-9760
EI 0717-6287
J9 BIOL RES
JI Biol. Res.
PD SEP 4
PY 2015
VL 48
AR 49
DI 10.1186/s40659-015-0040-9
PG 10
WC Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics
GA CQ4XU
UT WOS:000360608700001
PM 26337448
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Zou, XH
   Sun, Y
AF Zou, Xiaohan
   Sun, Yuan
TI Bibliometrics Analysis of the Research Status and Trends of the
   Association Between Depression and Insulin From 2010 to 2020
SO FRONTIERS IN PSYCHIATRY
LA English
DT Review
DE insulin; depression; sex hormones; bibliometric analysis; citespace
ID POLYCYSTIC-OVARY-SYNDROME; TESTOSTERONE LEVELS; MICE MODULATION;
   MESSENGER-RNA; ER-ALPHA; RESISTANCE; RECEPTOR; BRAIN; ESTROGEN; EXERCISE
AB Depression is one of the common mental illnesses. Because it is an important complication of diabetes, its association with changes in insulin levels and insulin resistance, the causative factors of diabetes, has attracted widespread attention. However, the association between insulin and depression has not been systematically studied through bibliometric and visual analysis. This study is based on 3131 publications of Web of Science to identify the current research status and research trends in this field. The results show that since 2010, the number of publications has been growing rapidly. Cooperative network analysis shows that the United States, the University of Toronto and Roger S Mcintyre are the most influential countries, research institutes and scholars, respectively. Insulin resistance, obesity, and metabolic syndrome are hot topics in this field. Analysis of keywords and references reveals that "sex hormones, " is new research area that constantly emerging. As far as we know, this study is the first one to visualize the association between depression and insulin and predict potential future research trends through bibliometric and visual analysis.
C1 [Zou, Xiaohan] Jilin Univ, Jilin Prov Key Lab Mol & Chem Genet, Hosp 2, Changchun, Peoples R China.
   [Sun, Yuan] Jilin Univ, Publ Comp Educ & Res Ctr, Changchun, Peoples R China.
C3 Jilin University; Jilin University
RP Sun, Y (corresponding author), Jilin Univ, Publ Comp Educ & Res Ctr, Changchun, Peoples R China.
EM sy@jlu.edu.cn
FU Jilin University
FX This work was supported by Jilin University.
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NR 69
TC 21
Z9 21
U1 6
U2 85
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-0640
J9 FRONT PSYCHIATRY
JI Front. Psychiatry
PD JUL 22
PY 2021
VL 12
AR 683474
DI 10.3389/fpsyt.2021.683474
PG 13
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA UE6GF
UT WOS:000687983500001
PM 34366917
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Hajat, C
   Siegal, Y
   Adler-Waxman, A
AF Hajat, Cother
   Siegal, Yakir
   Adler-Waxman, Amalia
TI Clustering and Healthcare Costs With Multiple Chronic Conditions in a US
   Study
SO FRONTIERS IN PUBLIC HEALTH
LA English
DT Article
DE cardiovascular disease; chronic disease; multimorbidity; cancer; mental
   health; healthcare costs; disease clustering
ID CARDIOVASCULAR-DISEASE; MULTIMORBIDITY; IMPACT; HOSPITALIZATION;
   EXPENDITURES; INEQUALITIES; COMORBIDITY; INTEGRATION; PREVALENCE; RISK
AB Objective: To investigate healthcare costs and contributors to costs for multiple chronic conditions (MCCs), common clusters of conditions and their impact on cost and utilization.
   Methods: This was a cross-sectional analysis of US financial claims data representative of the US population, including Medicare, Medicaid, and Commercial insurance claims in 2015. Outcome measures included healthcare costs and contributors; ranking of clusters of conditions according to frequency, strength of association and unsupervised (k-means) analysis; the impact of clustering on costs and contributors to costs.
   Results: Of 1,878,951 patients, 931,045(49.6%) had MCCs, 56.5% weighted to the US population. Mean age was 53.0 years (SD16.7); 393,121(42.20%) were male. Mean annual healthcare spending was $12,601, ranging from $4,385 (2 conditions) to $33,874 (11 conditions), with spending increasing by 22-fold for inpatient services, 6-fold for outpatient services, 4.5-fold for generic drugs, and 4.2-fold for branded drugs. Cluster ranking using the 3 methodologies yielded similar results: highest ranked clusters included metabolic syndrome (12.2% of US insured patients), age related diseases (7.7%), renal failure (5.6%), respiratory disorders (4.5%), cardiovascular disease(CVD) (4.3%), cancers (4.1-4.3%), mental health-related clusters (1.0-1.5%), and HIV/AIDS (0.2%). Highest spending was in HIV/AIDS clusters ($48,293), mental health-related clusters ($38,952-$40,637), renal disease ($38,551), and CVD ($37,155); with 89.9% of spending on outpatient and inpatient care combined, and 10.1% on medication.
   Conclusion and Relevance: Over 57% of insured patients in the US may have MCCs. MCC Clustering is frequent and is associated with healthcare utilization. The findings favor health system redesign toward a multiple condition approach for clusters of chronic conditions, alongside other cost-containment measures for MCCs.
C1 [Hajat, Cother] United Arab Emirates UAE Univ, Publ Hlth Inst, Al Ain, U Arab Emirates.
   [Siegal, Yakir] Deloitte Consulting LLP, New York, NY USA.
   [Adler-Waxman, Amalia] Teva Pharmaceut Ind Ltd, Petah Tiqwa, Israel.
C3 Deloitte Touche Tohmatsu Limited; Teva Pharmaceutical Industries
RP Hajat, C (corresponding author), United Arab Emirates UAE Univ, Publ Hlth Inst, Al Ain, U Arab Emirates.
EM Chajat@doctors.org.uk
OI Hajat, Cother/0000-0002-1763-3010
CR Academy of Medical Science, 2018, MULTIMORBIDITY PRIOR
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NR 39
TC 22
Z9 22
U1 1
U2 9
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 2296-2565
J9 FRONT PUBLIC HEALTH
JI Front. Public Health
PD JAN 21
PY 2021
VL 8
AR 607528
DI 10.3389/fpubh.2020.607528
PG 10
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA QB8JW
UT WOS:000614384600001
PM 33553094
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU He, XW
   Qi, ZD
   Hou, H
   Gao, J
   Zhang, XX
AF He, Xiwei
   Qi, Zhaodong
   Hou, Hui
   Gao, Jie
   Zhang, Xu-Xiang
TI Effects of chronic cadmium exposure at food limitation-relevant levels
   on energy metabolism in mice
SO JOURNAL OF HAZARDOUS MATERIALS
LA English
DT Article
DE Cadmium; Cardiometabolic risk; Chronic low-dose exposure; Energy
   metabolism; Mice gut microbes
ID FATTY LIVER-DISEASE; GUT MICROBIOTA; MECHANISMS; EXPRESSION; STRESS;
   HEART
AB Cadmium (Cd) exposure has been implicated in the perturbation of energy metabolism and the development of cardiometabolic disease, but disease predisposition from chronic low-dose Cd exposure remains unclear. This study employed a mouse model to investigate the toxic effects of chronic Cd exposure at food limitation-relevant levels on energy metabolism and the associated liver and gut microbiome functions. Results showed that the Cd exposure induced the perturbation of energy metabolism in mice, evidenced by the alteration of various metabolites associated with the phosphorogen (adenosine triphosphate-creatine phosphate) system, tricarboxylic acid cycle, and lipid metabolism, as well as the increase of the cardiometabolic risk factor, triglyceride. Moreover, both liver and gut microbiome underwent marked structural/histological and functional alterations, prone to the onset of cardiometabolic disease following the Cd exposure. Certain hepatic transcription factors and gut microbes, specifically PPARa, SREBP1c, HNF4A and the Clostridiales_vadinBB60_group, were identified to be highly correlated with altered urinary metabolites, revealing potential toxicological interactions between the liver and gut microbiome, and energy metabolism. Our findings provide new insights into the progression of metabolic diseases induced by Cd exposure. We also propose a stricter Cd limitation in future food safety standards.
C1 [He, Xiwei; Qi, Zhaodong; Hou, Hui; Gao, Jie; Zhang, Xu-Xiang] Nanjing Univ, Sch Environm, State Key Lab Pollut Control & Resource Reuse, Nanjing 210023, Peoples R China.
C3 Nanjing University
RP Zhang, XX (corresponding author), 163 Xianlin Rd, Nanjing 210023, Peoples R China.
EM zhangxx@nju.edu.cn
RI Hou, Huiqiao/KBB-4263-2024
OI Tekile, Ararso Beshea/0009-0005-4990-7118
FU National Key Research & Development Program of China [2018YFF0214105];
   Key R&D Program of Jiangsu Province, China [BE2018632]; Fundamental
   Research Funds for the Central Universities, China [14380116]
FX This study was financially supported by the National Key Research &
   Development Program of China (2018YFF0214105), the Key R&D Program of
   Jiangsu Province, China (BE2018632) and the Fundamental Research Funds
   for the Central Universities, China (14380116).
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NR 56
TC 30
Z9 31
U1 4
U2 80
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0304-3894
EI 1873-3336
J9 J HAZARD MATER
JI J. Hazard. Mater.
PD APR 15
PY 2020
VL 388
AR 121791
DI 10.1016/j.jhazmat.2019.121791
PG 9
WC Engineering, Environmental; Environmental Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering; Environmental Sciences & Ecology
GA LB2JV
UT WOS:000524462500064
PM 31818666
DA 2025-06-11
ER

PT J
AU Alim, NE
   Demir, G
   Dundar, S
   Fidan, ÖPT
   Coker, F
AF Alim, Nural Erzurum
   Demir, Gulbin
   Dundar, Selin
   Fidan, Oyku Peren Turk
   Coker, Fatma
TI Evaluation of Nutrient Intake in Bipolar Disorder I Patients According
   to Body Mass Index Level: A Pilot Study
SO PROGRESS IN NUTRITION
LA English
DT Article
DE Bipolar disorder; diet; obesity; body mass index; psychiatry
ID LIFE-STYLE FACTORS; GENDER-DIFFERENCES; METABOLIC SYNDROME; OBESITY;
   ASSOCIATION; PREVALENCE; HEALTH; ADULTS
AB Background: Bipolar disorders (BD) are severe psychiatric disorders defined by variable mania or hypomania attacks, depression, or mixtures of manic and depressive features. Bipolar disorder I (BDI) is associated with obesity and nutrition. Objectives: To determine the nutritional status and evaluate the anthropometric measurements of BDI patients at Samsun Mental Health and Diseases Hospital. Subjects and methods: This casecontrolled study was carried out among 50 BDI patients and 38 normal healthy volunteer individuals. Food frequency questionnaire was applied to the participants and anthropometric measurements were determined. Biochemical tests were retrospectively performed. Results: The mean energy, protein, and Omega 6 intake of the BDI group was significantly higher than the control group (p < 0.05). The mean waist circumference, waist/height ratio, and the frequency of obesity in the BDI group were statistically higher than the control group (p < 0.05). Hemoglobin, triglyceride, CRP and T3 were significantly higher in the BDI group compared to the control group (p < 0.05). Protein, lipid, carbohydrate, and fiber intake of the individuals differed according to their health status (p = 0.016, p < 0.001, p < 0.001, p = 0.007, respectively). At the same time, the interaction between health status and BMI levels was also significant (p = 0.019). Conclusions: The data obtained may help assess the nutrition of BDI patients. Nutritional assessment should be a part of the plan of care in BDI patients.
C1 [Alim, Nural Erzurum; Fidan, Oyku Peren Turk] Ankara Yildirim Beyazit Univ, Dept Nutr & Dietet, Fac Hlth Sci, TR-06760 Ankara, Turkey.
   [Demir, Gulbin; Coker, Fatma] Minist Hlth, Samsun Prov Hlth Directorate, Mental Hlth & Dis Hosp, Samsun, Turkey.
   [Dundar, Selin] Minist Hlth, Gen Directorate Publ Hlth, Canc Dept, TR-06100 Ankara, Turkey.
C3 Ankara Yildirim Beyazit University; Ministry of Health - Turkey;
   Ministry of Health - Turkey
RP Alim, NE (corresponding author), Ankara Yildirim Beyazit Univ, Dept Nutr & Dietet, Fac Hlth Sci, TR-06760 Ankara, Turkey.
EM nalim@ybu.edu.tr
RI ERZURUM ALIM, Nural/E-8236-2019
OI TURK, OYKU PEREN/0000-0003-1215-2581
CR [Anonymous], 2013, DIAGNOSTIC STAT MANU
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   [No title captured]
NR 34
TC 2
Z9 2
U1 0
U2 3
PU MATTIOLI 1885
PI FIDENZA
PA VIA DELLA LODESANA 649-SX, FIDENZA, 43046 PR, ITALY
SN 1129-8723
J9 PROG NUTR
JI Prog. Nutr.
PD SEP
PY 2020
VL 22
IS 3
AR e2020039
DI 10.23751/pn.v22i3.9542
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA OJ3QJ
UT WOS:000583879700040
DA 2025-06-11
ER

PT J
AU Satake, O
   Kajinami, K
   Ishikawa, Y
   Ueda, T
   Tsugawa, H
   Kanemitsu, S
   Okubo, S
   Takekoshi, N
AF Satake, O
   Kajinami, K
   Ishikawa, Y
   Ueda, T
   Tsugawa, H
   Kanemitsu, S
   Okubo, S
   Takekoshi, N
TI Myocardial glucose metabolism assessed by positron emission tomography
   and the histopathologic findings of microvessels in syndrome X
SO CIRCULATION JOURNAL
LA English
DT Article
DE histopathology; microvessels; positron emission tomography; syndrome X
ID NORMAL CORONARY-ARTERIES; ANGINA-PECTORIS; MICROVASCULAR ANGINA; CHEST
   PAIN; VASODILATOR RESERVE; HEART-DISEASE; FLOW RESERVE; ARTERIOGRAMS;
   PERFUSION; ISCHEMIA
AB Background Syndrome X has been recognized as a disease that is primarily reflected in the cardiac microvasculature. Myocardial metabolism in this condition has been studied, but not in relation to small vessel pathology.
   Methods and Results In order to examine the relationship between myocardial metabolism and small vessel pathology, 24 consecutive patients with syndrome X (7 men, 17 women; mean age 58 years) were evaluated by the thallium exercise stress test, positron emission tomography using F-18 fluoro-deoxy glucose (FDG), and an endomyocardial biopsy. All patients showed either diffuse or focal increase in the myocardial uptake of FDG, but only 17 patients (71%) showed hypoperfused areas with partial or complete redistribution in the thalliurn study. Quantification of myocardial FDG uptake revealed that the value in syndrome X patients was 10-fold higher than in controls (p<0.0001). Histopathological examination revealed that in syndrome X there is an extensive increase in smooth muscle cells and thickening of the vascular wall, even in capillary vessels, and the small vessel lumen was markedly narrowed. There was a significant inverse correlation between FDG myocardial uptake and the microvessel luminal area.
   Conclusions In syndrome X patients, myocardial FDG uptake is increased extensively, which is strongly associated with narrowed myocardial microvasculature.
C1 Kanazawa Med Univ, Dept Cardiol, Uchinada, Ishikawa 9200293, Japan.
   Kanazawa Med Univ, Dept Pathol 2, Uchinada, Ishikawa 9200293, Japan.
   Kanazawa Med Univ, Dept Anat, Uchinada, Ishikawa 9200293, Japan.
C3 Kanazawa Medical University; Kanazawa Medical University; Kanazawa
   Medical University
RP Kanazawa Med Univ, Dept Cardiol, 1-1 Daigaku, Uchinada, Ishikawa 9200293, Japan.
EM o-satake@kanazawa-med.ac.jp
RI Kajinami, Kouji/AAA-6769-2022
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NR 34
TC 17
Z9 18
U1 0
U2 1
PU JAPANESE CIRCULATION SOC
PI TOYKO
PA 6th Floor, Uchikanda Central Building, 1-18-13 Uchikanda, Chiyoda-ku,
   TOYKO, 101-0047, JAPAN
SN 1346-9843
EI 1347-4820
J9 CIRC J
JI Circ. J.
PD MAR
PY 2004
VL 68
IS 3
BP 220
EP 226
DI 10.1253/circj.68.220
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 779UJ
UT WOS:000189319500008
PM 14993776
OA Bronze
DA 2025-06-11
ER

PT J
AU Cranwell, K
   Polacsek, M
   McCann, TV
AF Cranwell, Kate
   Polacsek, Meg
   McCann, Terence V.
TI Improving mental health service users' with medical co-morbidity
   transition between tertiary medical hospital and primary care services:
   a qualitative study
SO BMC HEALTH SERVICES RESEARCH
LA English
DT Article
DE Service users' and caregivers' experience; Experience-based co-design;
   Mental Health Hospital Admission Reduction Program; Medical
   co-morbidity; Transition
ID METABOLIC SYNDROME; YOUNG-PEOPLE; ILLNESS; SCHIZOPHRENIA; STIGMA;
   DISCRIMINATION; SATISFACTION; EXPERIENCES; RELEVANCE
AB Background: Mental health service users have high rates of medical co-morbidity but frequently experience problems accessing and transitioning between tertiary medical and primary care services. The aim of this study was to identify ways to improve service users' with medical co-morbidity care and experience during their transition between tertiary medical hospitals and primary care services.
   Method: Experience-based co-design (EBCD) qualitative study incorporating a focus group discussion. The study took place in a large tertiary medical service, incorporating three medical hospitals, and primary care services, in Melbourne, Australia. A purposive sample of service users and their caregivers and tertiary medical and primary care clinicians participated in the focus group discussion, in August 2014. A semi-structured interview guide was used to inform data collection. A thematic analysis of the data was undertaken.
   Results: Thirteen participants took part in the focus group interview, comprising 5 service users, 2 caregivers and 6 clinicians. Five themes were abstracted from the data, illustrating participants' perspectives about factors that facilitated (clinicians' expertise, engagement and accessibility enhancing transition) and presented as barriers (improving access pathways; enhancing communication and continuity of care; improving clinicians' attitudes; and increasing caregiver participation) to service users' progress through tertiary medical and primary care services. A sixth theme, enhancing service users' transition, incorporated three strategies to enhance their transition through tertiary medical and primary care services.
   Conclusion: EBCD is a useful approach to collaboratively develop strategies to improve service users' with medical co-morbidity and their caregivers' transition between tertiary medical and primary care services. A whole-of-service approach, incorporating policy development and implementation, change of practice philosophy, professional development education and support for clinicians, and acceptance of the need for caregiver participation, is required to improve service users' transition.
C1 [Cranwell, Kate; Polacsek, Meg] Western Hlth, Community Serv, Melbourne, Vic, Australia.
   [Polacsek, Meg; McCann, Terence V.] Victoria Univ, Discipline Nursing, Coll Hlth & Biomed, Ctr Chron Dis, POB 14428, Melbourne, Vic 8001, Australia.
C3 Western Health; Victoria University
RP McCann, TV (corresponding author), Victoria Univ, Discipline Nursing, Coll Hlth & Biomed, Ctr Chron Dis, POB 14428, Melbourne, Vic 8001, Australia.
EM terence.mccann@vu.edu.au
OI Mccann, Terence/0000-0003-1109-0438; Polacsek, Meg/0000-0002-2945-3594
FU Australian Primary Health Care Research Institute, Canberra
FX The authors declare receipt of the following financial support for the
   study: The study was funded by a grant from the Australian Primary
   Health Care Research Institute, Canberra.
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NR 43
TC 16
Z9 18
U1 0
U2 20
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1472-6963
J9 BMC HEALTH SERV RES
JI BMC Health Serv. Res.
PD JUL 26
PY 2016
VL 16
AR 302
DI 10.1186/s12913-016-1567-3
PG 9
WC Health Care Sciences & Services
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services
GA DS2WS
UT WOS:000380645200004
PM 27456864
OA Green Published, Green Accepted, gold
DA 2025-06-11
ER

PT J
AU Pearsall, R
   Hughes, S
   Geddes, J
   Pelosi, A
AF Pearsall, Robert
   Hughes, Susan
   Geddes, John
   Pelosi, Anthony
TI Understanding the problems developing a healthy living programme in
   patients with serious mental illness: a qualitative study
SO BMC PSYCHIATRY
LA English
DT Article
DE Healthy living; Physical health; Qualitative study; Serious mental
   illness; Healthy living programme
ID PHYSICAL-ACTIVITY; WEIGHT-GAIN; ANTIPSYCHOTIC TREATMENT; METABOLIC
   SYNDROME; SMOKING-CESSATION; SCHIZOPHRENIA; PEOPLE; BARRIERS; RISK;
   MORTALITY
AB Background: People with serious mental illness are at an increased risk of physical ill health. Mortality rates are around twice those of the general population with higher levels of cardiovascular disease, metabolic disease, diabetes, and respiratory illness. Although genetics may have a role in the physical health problems of these patients, lifestyle and environmental factors such as smoking, obesity, poor diet, and low levels of physical activity play a prominent part.
   Methods: A qualitative grounded theory approach was used to understand the problems experienced by these individuals when asked to attend a healthy living programme. Three main areas were explored: the influence of potential barriers, health problems, and general attitudes towards healthy living.
   Results: Thirteen patients were interviewed during the study. Many did not recall receiving an initial invitation letter to the programme. Several believed that there was no necessity to attend as they had already had recent routine health checks by their general practitioner. The patients' current level of mental and physical health was important with symptoms such as depression, anxiety or arthritis affecting interest in the programme. Patients described that they found smoking enjoyable or calming in its effect. Dietary intake was determined by taste or gaining pleasure in eating certain types of food. Several lessons were learnt during this research that may aid future research and practice. Participation seemed to be better if the approach was first made by the patient's own community keyworker. This contact may have provided a greater opportunity to explain the purpose and importance of the programme. Alternative appointments should be considered when certain patients are in better physical and mental health. Healthy living programmes need to be flexible and adaptive to individual patient needs. Assistance from their community worker may help engagement. Simple measures may improve participation and reduce potential barriers.
   Conclusion: These findings highlighted some of the problems encountered by patients when attempting to participate in a healthy living programme. These results may be useful when implementing future healthy living interventions for patients with serious mental disorders.
C1 [Pearsall, Robert] Monklands Hosp, Dept Psychiat, Airdrie, AB, Canada.
   [Hughes, Susan] Community Hlth Clin, Carluke, Scotland.
   [Geddes, John] Univ Oxford, Dept Psychiat, Oxford, England.
   [Pelosi, Anthony] St Johns Hosp, Reg Eating Disorders Unit, Livingston, Scotland.
C3 University of Oxford
RP Pearsall, R (corresponding author), Monklands Hosp, Dept Psychiat, Airdrie, AB, Canada.
EM robert.pearsall@nhs.net
RI Geddes, John/B-8240-2011; Pelosi, Anthony/MTD-9608-2025
OI Geddes, John/0000-0002-5281-5960; Pelosi, Anthony/0000-0002-5501-2661
FU MRC; ESRC; NIHR; Stanley Medical Research Institute
FX RP, SH, and AP declared no competing interests. JG has received research
   funding from MRC, ESRC, NIHR, Stanley Medical Research Institute and has
   received donations of drugs supplies for trials from Sanofi-Aventis and
   GSK. He has acted as an expert witness for Dr Reddys.
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NR 33
TC 13
Z9 15
U1 0
U2 40
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-244X
J9 BMC PSYCHIATRY
JI BMC Psychiatry
PD FEB 14
PY 2014
VL 14
AR 38
DI 10.1186/1471-244X-14-38
PG 8
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA AC6ZE
UT WOS:000332674700001
PM 24524248
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Yuan, XL
   Liu, W
   Ni, WQ
   Sun, YY
   Zhang, HM
   Zhang, Y
   Yin, P
   Xu, J
AF Yuan, Xueli
   Liu, Wei
   Ni, Wenqing
   Sun, Yuanying
   Zhang, Hongmin
   Zhang, Yan
   Yin, Peng
   Xu, Jian
TI Concordance of Non-Alcoholic Fatty Liver Disease and Associated Factors
   among Older Married Couples in China
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Article
DE older couples; non-alcoholic fatty liver disease; spousal concordance;
   risk factors; lifestyle
ID SPOUSAL CONCORDANCE; METABOLIC SYNDROME; PHYSICAL HEALTH; MENTAL-HEALTH;
   DEPRESSION; SIMILARITY; MANAGEMENT; RISK
AB Background: Non-alcoholic fatty liver disease (NAFLD) is one of the most common liver diseases which affects mainly middle-aged and older adults, resulting in a considerable disease burden. Evidence of concordance on NAFLD and lifestyle factors within older married couples in China is limited. This study aimed to evaluate spousal concordance regarding lifestyle factors and NAFLD among older Chinese couples. Methods: We conducted a cross-sectional study using data from 58,122 married couples aged 65 years and over recruited from Shenzhen, China during 2018-2020. Logistic regression analyses were used to estimate the reciprocal associations in NAFLD within couples after incremental adjustment for potential confounders. Results: There was a marked concordance regarding NAFLD among older married couples in our study. After adjustment for confounders, the odds of having NAFLD were significantly related to the person's spouse also having NAFLD (1.84 times higher in husbands and 1.79 times higher in wives). The spousal concordance of NAFLD was similar, irrespective of gender. Couples with both a higher educational level and abdominal obesity were more likely to have a concordance of NAFLD compared to couples with both a lower educational level and no abdominal obesity, respectively (p < 0.05). Conclusion: Our results indicated that health care professionals should bear in mind the marked spousal concordance with respect to risk factors and NAFLD for the prevention and early detection of the highly prevalent disease in older Chinese adults.
C1 [Yuan, Xueli; Ni, Wenqing; Sun, Yuanying; Zhang, Hongmin; Zhang, Yan; Xu, Jian] Shenzhen Ctr Chron Dis Control, Dept Elderly Hlth Management, Shenzhen 518020, Peoples R China.
   [Liu, Wei; Yin, Peng] Chinese Ctr Dis Control & Prevent, Natl Ctr Chron & Noncommunicable Dis Control & Pre, Beijing 100050, Peoples R China.
C3 Chinese Center for Disease Control & Prevention
RP Xu, J (corresponding author), Shenzhen Ctr Chron Dis Control, Dept Elderly Hlth Management, Shenzhen 518020, Peoples R China.; Yin, P (corresponding author), Chinese Ctr Dis Control & Prevent, Natl Ctr Chron & Noncommunicable Dis Control & Pre, Beijing 100050, Peoples R China.
EM yinpeng@ncncd.chinacdc.cn; anniexu73@126.com
RI xu, jian/GQQ-4903-2022; ni, wenqing/ABE-4730-2020; Yin,
   Peng/AFP-5157-2022
OI Liu, Wei/0000-0002-1737-8013
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NR 44
TC 4
Z9 4
U1 2
U2 10
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD JAN
PY 2023
VL 20
IS 2
AR 1426
DI 10.3390/ijerph20021426
PG 11
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA 7Y9RK
UT WOS:000915206500001
PM 36674180
OA gold, Green Published
DA 2025-06-11
ER

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AF Mirmira, Raghavendra G.
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   Knutson, Kristen L.
   Reutrakul, Sirimon
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   Sargis, Robert M.
   Wallia, Amisha
   Tuchman, Arleen M.
   Weissberg-Benchell, Jill
   Danielson, Kirstie K.
   Oakes, Scott A.
   Thomas, Celeste C.
   Layden, Brian T.
   May, Sarah C.
   Burbea Hoffmann, Michelle
   Gatta, Eleonora
   Solway, Julian
   Philipson, Louis H.
TI Stress and human health in diabetes: A report from the 19<SUP>th</SUP>
   Chicago Biomedical Consortium symposium
SO JOURNAL OF CLINICAL AND TRANSLATIONAL SCIENCE
LA English
DT Article
DE Diabetes; stress; beta cells; metabolic syndrome; diabetes technology;
   healthcare; community
ID ENDOCRINE-DISRUPTING CHEMICALS; ESTROGEN-RECEPTOR-ALPHA; SLEEP
   EXTENSION; INSULIN SENSITIVITY; GLYCEMIC CONTROL; BODY-WEIGHT; OBESITY;
   ADULTS; ASSOCIATION; NEURONS
AB Stress and diabetes coexist in a vicious cycle. Different types of stress lead to diabetes, while diabetes itself is a major life stressor. This was the focus of the Chicago Biomedical Consortium's 19th annual symposium, "Stress and Human Health: Diabetes," in November 2022. There, researchers primarily from the Chicago area met to explore how different sources of stress - from the cells to the community - impact diabetes outcomes. Presenters discussed the consequences of stress arising from mutant proteins, obesity, sleep disturbances, environmental pollutants, COVID-19, and racial and socioeconomic disparities. This symposium showcased the latest diabetes research and highlighted promising new treatment approaches for mitigating stress in diabetes.
C1 [Mirmira, Raghavendra G.; Thomas, Celeste C.; May, Sarah C.] Univ Chicago, Kovler Diabet Ctr, Dept Med, Chicago, IL USA.
   [Kulkarni, Rohit N.] Harvard Stem Cell Inst, Joslin Diabet Ctr, Beth Israel Deaconess Med Ctr, Dept Med,Islet Cell & Regenerat Biol, Boston, MA USA.
   [Xu, Pingwen; Reutrakul, Sirimon; Sargis, Robert M.; Danielson, Kirstie K.] Univ Illinois, Dept Med, Div Endocrinol Diabet & Metab, Chicago, IL USA.
   [Drossos, Tina] Univ Chicago, Pritzker Sch Med, Dept Psychiat & Behav Neurosci, Chicago, IL USA.
   [Varady, Krista] Univ Illinois, Dept Kinesiol & Nutr, Chicago, IL USA.
   [Knutson, Kristen L.] Northwestern Univ, Ctr Circadian & Sleep Med, Feinberg Sch Med, Dept Neurol, Chicago, IL USA.
   [Martyn-Nemeth, Pamela] Univ Illinois, Dept Biobehav Nursing Sci, Coll Nursing, Chicago, IL USA.
   [Sargis, Robert M.] Jesse Brown VA Med Ctr, Dept Med, Sect Endocrinol Diabet & Metab, Chicago, IL USA.
   [Wallia, Amisha] Northwestern Univ, Feinberg Sch Med, Dept Med, Div Endocrinol Metab & Mol Med, Chicago, IL USA.
   [Tuchman, Arleen M.] Vanderbilt Univ, Dept Hist, Nashville, TN USA.
   [Weissberg-Benchell, Jill] Northwestern Univ, Ann & Robert H Lurie Childrens Hosp Chicago, Feinberg Sch Med, Dept Psychiat & Behav Sci, Chicago, IL USA.
   [Oakes, Scott A.] Univ Chicago, Dept Pathol, Chicago, IL USA.
   [Layden, Brian T.] Univ Chicago, Sect Adult & Pediat Endocrinol Diabet & Metab, Chicago, IL USA.
   [Burbea Hoffmann, Michelle; Gatta, Eleonora] Chicago Biomed Consortium, Evanston, IL USA.
   [Solway, Julian] Univ Chicago, Dept Med, Chicago, IL USA.
   [Philipson, Louis H.] Univ Chicago, Dept Med & Pediat, Sect Adult & Pediat Endocrinol Diabet & Metab, Chicago, IL 60637 USA.
C3 University of Chicago; Harvard University; Harvard University Medical
   Affiliates; Joslin Diabetes Center, Inc.; Beth Israel Deaconess Medical
   Center; University of Illinois System; University of Illinois Chicago;
   University of Illinois Chicago Hospital; University of Chicago;
   University of Illinois System; University of Illinois Chicago;
   University of Illinois Chicago Hospital; Northwestern University;
   Feinberg School of Medicine; University of Illinois System; University
   of Illinois Chicago; University of Illinois Chicago Hospital; US
   Department of Veterans Affairs; Veterans Health Administration (VHA);
   Jesse Brown VA Medical Center; Northwestern University; Feinberg School
   of Medicine; Vanderbilt University; Ann & Robert H. Lurie Children's
   Hospital of Chicago; Northwestern University; Feinberg School of
   Medicine; University of Chicago; University of Chicago; University of
   Chicago; University of Chicago
RP Philipson, LH (corresponding author), Univ Chicago, Dept Med & Pediat, Sect Adult & Pediat Endocrinol Diabet & Metab, Chicago, IL 60637 USA.
EM l-philipson@uchicago.edu
RI Mirmira, Raghavendra/AAD-7592-2020; Danielson, Kirstie/C-4134-2013;
   Martyn-Nemeth, Pamela/JLM-9620-2023; Xu, Pingwen/GRR-9137-2022
OI Knutson, Kristen/0000-0002-2751-6168; Reutrakul,
   Sirimon/0000-0002-0686-1069; May, Sarah/0000-0003-4567-7480
FU Chicago Biomedical Consortium; Searle Funds at The Chicago Community
   Trust; Chicago Center for Diabetes Translation Research [NIDDK P30
   DK092949]; Dean's Office of the Biological Sciences Division of the
   University of Chicago; University of Illinois Chicago [CCTS
   UL1TR002003]; NIH/NIDDK [R01DK121726]; National Institutes of Health
   [R01 ES028879, R21 ES030884, P30 ES027792, UL1 TR002003]; NIDDK [RO1
   67536, UO1 DK135095]; NIH [R01 DK123098, R01CA219815, R01EY027810,
   U01DK127786]
FX This symposium was funded by the Chicago Biomedical Consortium with
   support from the Searle Funds at The Chicago Community Trust. PMN is
   funded by the Chicago Center for Diabetes Translation Research(NIDDK P30
   DK092949); the Dean's Office of the Biological Sciences Division of the
   University of Chicago, the University of Illinois Chicago (Grant No.
   CCTS UL1TR002003) and NIH/NIDDK, R01DK121726. RMS has been supported by
   the National Institutes of Health (R01 ES028879, R21 ES030884, P30
   ES027792, and UL1 TR002003). RNK is supported by NIDDK RO1 67536 and UO1
   DK135095. PX is supported by NIH R01 DK123098. SAO is funded by
   R01CA219815, R01EY027810, U01DK127786. RMS: The views expressed in this
   article are those of the authors and do not necessarily reflect the
   position or policy of the Department of Veterans Affairs or the United
   States Government.
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NR 107
TC 0
Z9 0
U1 1
U2 4
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
EI 2059-8661
J9 J CLIN TRANSL SCI
JI J. Clin. Transl. Sci.
PD NOV 20
PY 2023
VL 7
IS 1
AR e263
DI 10.1017/cts.2023.646
PG 8
WC Medicine, Research & Experimental
WE Emerging Sources Citation Index (ESCI)
SC Research & Experimental Medicine
GA CJ5X6
UT WOS:001124909700001
PM 38229904
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Janczura, M
   Rosa, R
   Dropinski, J
   Gielicz, A
   Stanisz, A
   Kotula-Horowitz, K
   Domagala, T
AF Janczura, Miroslaw
   Rosa, Rafal
   Dropinski, Jerzy
   Gielicz, Anna
   Stanisz, Andrzej
   Kotula-Horowitz, Katarzyna
   Domagala, Teresa
TI The Associations of Perceived and Oxidative Stress with Hypertension in
   a Cohort of Police Officers
SO DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
LA English
DT Article
DE metabolic syndrome; obesity; hypertension; perceived stress; oxidative
   stress; physical activity
ID METABOLIC SYNDROME; CARDIOVASCULAR-DISEASE; PHYSICAL-ACTIVITY;
   BLOOD-PRESSURE; MYOCARDIAL-INFARCTION; RISK-FACTORS; 8-ISOPROSTANE;
   F-2-ISOPROSTANES; MECHANISMS; COUNTRIES
AB Purpose: Associations between perceived stress and oxidative stress marker and metabolic syndrome (MetS) components were investigated in a cohort of police officers.
   Methods: Cross-sectional data from a cohort of non-diabetic subjects (n=233; 19F), median [interquartile range] age 50 [37-44] years, were analysed. MetS was construed in line with International Diabetes Federation (IDF) criteria and perceived stress with Cohen's 10-item Perceived Stress Scale. Plasma oxidative stress marker (free 8-iso-prostaglandin F-2 alpha 8-iso-PGF(2 alpha)), presence of coronary plaque, carotid artery intima-media thickness (cIMT), and physical activity level were also determined.
   Results: Obesity was established in 100 (42.92%), hypertension in 111 (47.64), whereas MetS was identified in 104 (44.63%) of the study subjects. A significant difference (p=0.003) in plasma 8-iso-PGF(2 alpha) level, depending on the MetS components status, was noted. The associations of perceived stress with plasma 8-iso-PGF(2 alpha) level and the select study variables were gender-specific. In multivariate analysis (adjusted for age and current smoking), positive associations of plasma 8-iso-PGF(2 alpha) levels with PSS score (B=0.108, 95% CI [0.008, 0.209], p=0.03) and systolic blood pressure (B=0.029, 95% CI [0.003, 0.057], p=0.02) in men only were established. Both the perceived stress (OR 1.101, 95% CI [1.001-1.202], p=0.03) and plasma 8-iso-PGF(2 alpha) levels (OR 1.223, 95% CI [1.046-1.432], p=0.01) impacted the prevalence of hypertension. Out of the MetS components, the effect of waist circumference (OR=1.138, 95% CI [1.064-1.218], p=0.0001) and glucose (B=2.696, 95% CI [1.081-6.725], p=0.03) were also encountered. No such associations were noted in women, though, neither in univariate nor in multivariate analyses. The prevalence of coronary plaque (0.001), obesity (p<0.001), hypertension (p<0.001) and median cIMT value (p=0.005), as well as leisure-time (p=0.04) and total walking physical activity (p=0.03), differed significantly between the subgroups stratified by MetS components status.
   Conclusion: Both the perceived and oxidative stress were found instrumental in promoting hypertension in a cohort of police officers under study, whereas all study outcomes were conclusively gender-related.
C1 [Janczura, Miroslaw] Jagiellonian Univ, Fac Hlth Sci, Sch Med, Krakow, Poland.
   [Rosa, Rafal] Minist Interior & Adm, Dept Anesthesiol & Intens Care, Hlth Care Ctr, Krakow, Poland.
   [Dropinski, Jerzy; Gielicz, Anna] Jagiellonian Univ, Dept Internal Med, Sch Med, Krakow, Poland.
   [Stanisz, Andrzej] Jagiellonian Univ, Dept Bioinformat & Telemed, Sch Med, Krakow, Poland.
   [Kotula-Horowitz, Katarzyna] Minist Interior & Adm, Hlth Care Ctr, Dept Internal Med, Krakow, Poland.
   [Domagala, Teresa] Jagiellonian Univ, Dept Med Biochem, Sch Med, Krowoderska 68-11, PL-31158 Krakow, Poland.
C3 Jagiellonian University; Jagiellonian University; Jagiellonian
   University; Jagiellonian University
RP Domagala, T (corresponding author), Jagiellonian Univ, Dept Med Biochem, Sch Med, Krowoderska 68-11, PL-31158 Krakow, Poland.
EM domagala32@yahoo.com
RI Gielicz, Anna/MTC-4051-2025; Janczura, Miroslaw/HSE-9726-2023
OI Janczura, Miroslaw/0000-0001-8485-0683
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NR 61
TC 6
Z9 6
U1 0
U2 2
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-7007
J9 DIABET METAB SYND OB
JI Diabetes Metab. Syndr. Obes.
PY 2021
VL 14
BP 1783
EP 1797
DI 10.2147/DMSO.S298596
PG 15
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA RU0TG
UT WOS:000644864700001
PM 33953580
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Wang, X
   Zhang, ZF
   Zheng, GH
   Wang, AM
   Sun, CH
   Qin, SP
   Zhuang, J
   Lu, J
   Ma, DF
   Zheng, YL
AF Wang, Xin
   Zhang, Zi-Feng
   Zheng, Gui-Hong
   Wang, Ai-Min
   Sun, Chun-Hui
   Qin, Su-Ping
   Zhuang, Juan
   Lu, Jun
   Ma, Dai-Fu
   Zheng, Yuan-Lin
TI The Inhibitory Effects of Purple Sweet Potato Color on Hepatic
   Inflammation Is Associated with Restoration of NAD<SUP>+</SUP> Levels
   and Attenuation of NLRP3 Inflammasome Activation in
   High-Fat-Diet-Treated Mice
SO MOLECULES
LA English
DT Article
DE purple sweet potato color; hepatic inflammation; NAD(+); NLRP3
   inflammasome; high-fat diet
ID ENDOPLASMIC-RETICULUM STRESS; ER STRESS; OXIDATIVE STRESS; NICOTINAMIDE
   RIBOSIDE; ANTIOXIDANT ACTIVITY; INSULIN SENSITIVITY; GUT MICROBIOTA;
   ADIPOSE-TISSUE; D-GALACTOSE; LIVER
AB Purple sweet potato color (PSPC), a class of naturally occurring anthocyanins, exhibits beneficial effects on metabolic syndrome. Sustained inflammation plays a crucial role in the pathogenesis of metabolic syndrome. Here we explored the effects of PSPC on high-fat diet (HFD)-induced hepatic inflammation and the mechanisms underlying these effects. Mice were divided into four groups: Control group, HFD group, HFD + PSPC group, and PSPC group. PSPC was administered by daily oral gavage at doses of 700 mg/kg/day for 20 weeks. Nicotinamide riboside (NR) was used to increase NAD(+) levels. Our results showed that PSPC effectively ameliorated obesity and liver injuries in HFD-fed mice. Moreover, PSPC notably blocked hepatic oxidative stress in HFD-treated mice. Furthermore, PSPC dramatically restored NAD(+) level to abate endoplasmic reticulum stress (ER stress) in HFD-treated mouse livers, which was confirmed by NR treatment. Consequently, PSPC remarkably suppressed the nuclear factor-kappa B (NF-kappa B) p65 nuclear translocation and nucleotide oligomerization domain protein1/2 (NOD1/2) signaling in HFD-treated mouse livers. Thereby, PSPC markedly diminished the NLR family, pyrin domain containing 3 (NLRP3) inflammasome activation, ultimately lowering the expressions of inflammation-related genes in HFD-treated mouse livers. In summary, PSPC protected against HFD-induced hepatic inflammation by boosting NAD(+) level to inhibit NLRP3 inflammasome activation.
C1 [Wang, Xin; Zhang, Zi-Feng; Zheng, Gui-Hong; Wang, Ai-Min; Sun, Chun-Hui; Qin, Su-Ping; Zhuang, Juan; Lu, Jun; Zheng, Yuan-Lin] Jiangsu Normal Univ, Sch Life Sci, Key Lab Biotechnol Med Plants Jiangsu Prov, Xuzhou 221116, Peoples R China.
   [Wang, Xin; Ma, Dai-Fu] Jiangsu Xuzhou Sweetpotato Res Ctr, Key Lab Biol & Genet Improvement Sweetpotato, Minist Agr, Xuzhou 221131, Peoples R China.
C3 Jiangsu Normal University; Ministry of Agriculture & Rural Affairs;
   Jiangsu Academy of Agricultural Sciences
RP Zhang, ZF; Zheng, YL (corresponding author), Jiangsu Normal Univ, Sch Life Sci, Key Lab Biotechnol Med Plants Jiangsu Prov, Xuzhou 221116, Peoples R China.
EM xznkywx@163.com; zhangzifengsuper@jsnu.edu.cn; 6020030110@jsnu.edu.cn;
   aiminwang@jsnu.edu.cn; 6020110036@jsnu.edu.cn; qinsuping1234@163.com;
   dajiangsky@163.com; lu-jun75@163.com; daifuma@163.com;
   ylzheng@jsnu.edu.cn
RI Lu, Jun/N-6109-2019
OI Lu, Jun/0000-0002-2801-5330
FU Priority Academic Program Development of Jiangsu Higher Education
   Institutions (PAPD); National Natural Science Foundation of China
   [81570531, 81571055]; China Agriculture Research System-sweetpotato
   [CARS-10]; Key Research and Development Plan of Jiangsu Province
   [BE2015313]; Scientific Research Support Project for Teachers with
   Doctor's Degrees [15XLR005]; Natural Science Foundation of Jiangsu
   Province [BK20131127]; Graduate Student Innovation Program of Jiangsu
   Province [KYZZ_0395, KYZZ16_0467]
FX This work is supported by the Priority Academic Program Development of
   Jiangsu Higher Education Institutions (PAPD); the National Natural
   Science Foundation of China (81570531, 81571055); the China Agriculture
   Research System-sweetpotato (CARS-10); the Key Research and Development
   Plan of Jiangsu Province (BE2015313); the Scientific Research Support
   Project for Teachers with Doctor's Degrees (15XLR005); Natural Science
   Foundation of Jiangsu Province (BK20131127); and the Graduate Student
   Innovation Program of Jiangsu Province (KYZZ_0395, KYZZ16_0467).
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NR 55
TC 32
Z9 33
U1 1
U2 18
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1420-3049
J9 MOLECULES
JI Molecules
PD AUG
PY 2017
VL 22
IS 8
AR 1315
DI 10.3390/molecules22081315
PG 16
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA FF0PF
UT WOS:000408602900080
PM 28786950
OA gold, Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Cheng, X
   Guo, QY
   Ju, LH
   Gong, WY
   Wei, XQ
   Xu, XL
   Zhao, LY
   Fang, HY
AF Cheng, Xue
   Guo, Qiya
   Ju, Lahong
   Gong, Weiyi
   Wei, Xiaoqi
   Xu, Xiaoli
   Zhao, Liyun
   Fang, Hongyun
TI Association between sedentary behavior, screen time and metabolic
   syndrome among Chinese children and adolescents
SO BMC PUBLIC HEALTH
LA English
DT Article
DE Sedentary time; Screen time; Metabolic syndrome; Children and
   adolescents; China
ID ABDOMINAL ADIPOSE-TISSUE; PHYSICAL-ACTIVITY; RISK-FACTORS; PREVALENCE;
   DEPRESSION; ANXIETY; HEALTH
AB BackgroundThe aim of the study was to investigate the relationship between sedentary behavior, screen time and MetS among Chinese children and adolescents aged 7-17 years. Data was obtained from the China National Nutrition and Health Surveillance of Children and Lactating Mothers in 2016-2017.MethodsData on sedentary time, screen time, and MetS indicators were obtained through physical and health questionnaires, anthropometric measurements, and clinical examinations. MetS was defined according to the Cook's criteria. Wilcoxon rank sum test and chi-square test were applied for comparisons of measurement data and counting data, respectively. The relationship between sedentary time, screen time, and MetS and its components was analyzed using a multivariate logistic regression model.ResultsThe prevalence of MetS among 7-17-year-old students in 2016-2017 was 5.45%. Compared to those with low sedentary behavior, in high sedentary behavior groups, the prevalence of abdominal obesity, high TG, low HDL-C, and MetS was high in boys, and the prevalence of abdominal obesity, high TG, hyperglycemia, and MetS was high in girls. Moreover, for those who reported >= 3 h/day of screen time, the prevalence of abdominal obesity, low HDL-C, and MetS was higher in boys, and the prevalence of abdominal obesity and MetS was higher in girls. After adjusting for confounding variables, the risks of abdominal obesity, high TG, low HDL-C, and MetS were higher in high-level sedentary time group, and the risks of abdominal obesity and MetS were 1.15 and 1.14 times higher for those who spent >= 3 h/day on screen time, respectively.ConclusionsThis study shows that high levels of sedentary time and screen time were associated with an increased likelihood of MetS among Chinese children and adolescents aged 7-17 years. Reducing sedentary behavior and screen time may contribute to the prevention of metabolic diseases.
C1 [Cheng, Xue; Guo, Qiya; Ju, Lahong; Gong, Weiyi; Wei, Xiaoqi; Xu, Xiaoli; Zhao, Liyun; Fang, Hongyun] Natl Inst Nutr & Hlth, Chinese Ctr Dis Control & Prevent, Beijing 100050, Peoples R China.
   [Ju, Lahong; Zhao, Liyun; Fang, Hongyun] Natl Inst Nutr & Hlth, Chinese Ctr Dis Control & Prevent, NHC Key Lab Trace Element Nutr, Beijing 100050, Peoples R China.
C3 Chinese Center for Disease Control & Prevention; Chinese Center for
   Disease Control & Prevention; National Institute for Nutrition & Health,
   Chinese Center for Disease Control & Prevention
RP Fang, HY (corresponding author), Natl Inst Nutr & Hlth, Chinese Ctr Dis Control & Prevent, Beijing 100050, Peoples R China.; Fang, HY (corresponding author), Natl Inst Nutr & Hlth, Chinese Ctr Dis Control & Prevent, NHC Key Lab Trace Element Nutr, Beijing 100050, Peoples R China.
EM fanghy@ninh.chinacdc.cn
RI Gong, Weiyi/KMX-3943-2024
FU National Health Commission of the People's Republic of China Medical
   Reform Major Program: China National Chronic Diseases and Nutrition
   Surveillance of Adults (2015-2017)
FX This study was supported by the National Health Commission of the
   People's Republic of China Medical Reform Major Program: China National
   Chronic Diseases and Nutrition Surveillance of Adults (2015-2017).
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NR 47
TC 3
Z9 3
U1 10
U2 15
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2458
J9 BMC PUBLIC HEALTH
JI BMC Public Health
PD JUN 27
PY 2024
VL 24
IS 1
AR 1715
DI 10.1186/s12889-024-19227-w
PG 8
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA WX2E4
UT WOS:001258095100001
PM 38937700
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Homberg, JR
   la Fleur, SE
   Cuppen, E
AF Homberg, Judith R.
   la Fleur, Susanne E.
   Cuppen, Edwin
TI Serotonin Transporter Deficiency Increases Abdominal Fat in Female, but
   Not Male Rats
SO OBESITY
LA English
DT Article
ID KNOCK-OUT MICE; METABOLIC SYNDROME; 5-HT1A RECEPTOR; BRAIN; OBESITY;
   REGION; POLYMORPHISM; EXPRESSION; DEPRESSION; GENDER
AB Depression and abdominal obesity often co-occur, predominantly in women, and are associated with an increased risk for the development of glucose intolerance and subsequently type 2 diabetes. The underlying mechanisms are poorly understood. We found that female, but not male, depression-prone serotonin transporter knockout (SERT-/-) rats had a strong increase (54%) in abdominal fat, whereas no increases in plasma concentrations of glucose and insulin were observed. Surprisingly, application of a high-fat, high-sucrose (HFHS)-choice diet, which results in increased abdominal fat deposition and increased plasma glucose levels in wild-type rats, did not result in elevated plasma glucose levels in female SERT-/- rats. Our results show that serotonin transporter deficiency affects abdominal fat deposition in a sex-dependent way, but protects against rises in glucose levels, and thereby potentially glucose intolerance. The increased abdominal fat formation could result from serotonin-mediated developmental changes and provides heuristic value for understanding the effects of the depression-associated serotonin transporter promoter polymorphism in humans.
C1 [Homberg, Judith R.; Cuppen, Edwin] Univ Med Ctr Utrecht, Hubrecht Inst, Utrecht, Netherlands.
   [Homberg, Judith R.] Radboud Univ Nijmegen, Med Ctr, Dept Cognit Neurosci 126, Ctr Neurosci,Donders Inst Brain Cognit & Behav, NL-6525 ED Nijmegen, Netherlands.
   [la Fleur, Susanne E.] Univ Med Ctr Utrecht, Dept Neurosci & Pharmacol, Rudolf Magnus Inst Neurosci, Utrecht, Netherlands.
   [la Fleur, Susanne E.] Univ Amsterdam, Acad Med Ctr, Dept Endocrinol & Metab, NL-1105 AZ Amsterdam, Netherlands.
C3 Royal Netherlands Academy of Arts & Sciences; Hubrecht Institute (KNAW);
   Utrecht University; Utrecht University Medical Center; Radboud
   University Nijmegen; Utrecht University; Utrecht University Medical
   Center; University of Amsterdam; Academic Medical Center Amsterdam
RP Cuppen, E (corresponding author), Univ Med Ctr Utrecht, Hubrecht Inst, Utrecht, Netherlands.
EM e.cuppen@niob.knaw.nl
RI Homberg, J.R./N-4172-2019; Cuppen, Edwin/H-2389-2016
OI Homberg, Judith/0000-0002-7621-1010; Cuppen, Edwin/0000-0002-0400-9542
FU Netherlands Organisation for Scientific Research (NWO) [91676160];
   European Heads of Research Councils; European Science Foundation EURYI
   (European Young Investigator)
FX We like to acknowledge Mieneke Luijendijk for technical assistance and
   Mark Verheul for genotyping of animals. This work is funded by The
   Netherlands Organisation for Scientific Research (NWO), grant #91676160,
   awarded to J.R.H. and the award "Exploiting natural and induced genetic
   variation in the laboratory rat" to E. C. from the European Heads of
   Research Councils and European Science Foundation EURYI (European Young
   Investigator) Awards scheme. NWO, the European Heads of Research
   Councils, and the European Science Foundation had no further role in
   study design; in the collection, analysis, and interpretation of data;
   in the writing of the report; and in the decision to submit the paper
   for publication.
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NR 32
TC 26
Z9 28
U1 0
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1930-7381
EI 1930-739X
J9 OBESITY
JI Obesity
PD JAN
PY 2010
VL 18
IS 1
BP 137
EP 145
DI 10.1038/oby.2009.139
PG 9
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 538UU
UT WOS:000273210400020
PM 19444235
OA Bronze
DA 2025-06-11
ER

PT J
AU Bourebaba, L
   Michalak, I
   Röcken, M
   Marycz, K
AF Bourebaba, Lynda
   Michalak, Izabela
   Roecken, Michael
   Marycz, Krzysztof
TI Cladophora glomerata methanolic extract decreases oxidative
   stress and improves viability and mitochondrial potential in equine
   adipose derived mesenchymal stem cells (ASCs)
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Article
DE Cladophora glomerata; EMS; ASCs; Oxidative stress; Mitopotential;
   Inflammation
ID ENDOPLASMIC-RETICULUM STRESS; HYDROGEN-PEROXIDE; ANTIOXIDANT ENZYMES;
   FREE-RADICALS; AMINO-ACIDS; FATTY-ACIDS; APOPTOSIS; DAMAGE; DYSFUNCTION;
   MACROALGAE
AB Reactive oxygen species (ROS) are key mediators of several cellular damage and thus associated with equine diseases such as inflammation and metabolic syndrome. This study aimed to evaluate the protective and antioxidant activities of methanolic extract prepared from Cladophora glomerata (C. glomerata) biomass, on equine adipose derived mesenchymal stem cells (EqASCs), under experimental oxidative stress induced by H2O2. Pretreatment of EqASCs cells with different concentrations of C. glomerata methanolic extract (1% and 5%) provided a clear protection against cellular damage triggered by H2O2. The cell's apoptotic status was significantly regulated, with promotion of cell viability, down-regulation of pro-apoptotic (p21, p53, Bax and Casp-9) genes expression, concomitant to up-regulation of the survival gene Bcl-2, this being supported by a mitigation of the endoplasmic reticulum (ER) stress and significant minimization of mitochondrial dysfunction. The results also showed that C. glomerata extract significantly increased the antioxidant enzymes Superoxide dismutase (SOD) and Catalase (CAT) activities, positively regulated the enzymes genes expression, and markedly reduced the protein carbonyls derivatives production. Finally, RT-qPCR analysis of the inflammatory related genes allowed to highlight a promising anti-inflammatory and immunomodulatory effect of this extract. Due to the valuable antioxidant and anti-inflammatory activities, C. glomerata may have potential benefits for the prevention of equine diseases associated with oxidative stress, including metabolic syndrome.
C1 [Bourebaba, Lynda; Marycz, Krzysztof] Wroclaw Univ Environm & Life Sci, Fac Biol & Anim Sci, Dept Expt Biol, Norwida 27B, PL-50375 Wroclaw, Poland.
   [Michalak, Izabela] Wroclaw Univ Sci & Technol, Fac Chem, Dept Adv Mat Technol, Smoluchowskiego 25, PL-50372 Wroclaw, Poland.
   [Roecken, Michael; Marycz, Krzysztof] Justus Liebig Univ, Equine Clin Equine Surg, Fac Vet Med, D-35392 Giessen, Germany.
C3 Wroclaw University of Environmental & Life Sciences; Wroclaw University
   of Science & Technology; Justus Liebig University Giessen
RP Marycz, K (corresponding author), Wroclaw Univ Environm & Life Sci, Fac Biol & Anim Sci, Dept Expt Biol, Norwida 27B, PL-50375 Wroclaw, Poland.
EM krzysztof.marycz@upwr.edu.pl
RI Bourebaba, Lynda/AAX-7613-2020; Michalak, Izabela/P-3770-2015
OI Michalak, Izabela/0000-0001-8084-9642; Lynda,
   Bourebaba/0000-0003-0660-8706
FU grant entitled "The effect of bioactive algae enriched by biosorption on
   the certain minerals such as Cr(III), Mg(II) and Mn(II) on the status of
   glucose in the course of metabolic syndrome horses. Evaluation in vitro
   and in vivo" by The National Science C [2015/18/E/NZ9/00607]
FX This manuscript is financed in the framework of grant entitled "The
   effect of bioactive algae enriched by biosorption on the certain
   minerals such as Cr(III), Mg(II) and Mn(II) on the status of glucose in
   the course of metabolic syndrome horses. Evaluation in vitro and in
   vivo" (2015/18/E/NZ9/00607) attributed by The National Science Centre in
   Poland.
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NR 59
TC 28
Z9 29
U1 0
U2 6
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD MAR
PY 2019
VL 111
BP 6
EP 18
DI 10.1016/j.biopha.2018.12.020
PG 13
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA HL5AK
UT WOS:000458737800002
PM 30553132
OA gold
DA 2025-06-11
ER

PT J
AU Karasek, R
   Collins, S
   Clays, E
   Bortkiewicz, A
   Ferrario, M
AF Karasek, Robert
   Collins, Sean
   Clays, Els
   Bortkiewicz, Alicja
   Ferrario, Marco
TI DESCRIPTION OF A LARGE-SCALE STUDY DESIGN TO ASSESS WORK-STRESS-DISEASE
   ASSOCIATIONS FOR CARDIOVASCULAR DISEASE
SO INTERNATIONAL JOURNAL OF OCCUPATIONAL MEDICINE AND ENVIRONMENTAL HEALTH
LA English
DT Review
DE Stress; Cardiovascular disease; Low control; Growth and regeneration;
   Large-scale study design
ID HEART-RATE-VARIABILITY; AMBULATORY BLOOD-PRESSURE; RISK-FACTORS; JOB
   STRAIN; CORONARY RISK; TRENDS
AB We claim that a new level of studies is needed to answer a series of important questions about the expanding global chronic disease burden for cardiovascular disease (CVD) and for related conditions such as diabetes, metabolic syndrome, and obesity. These require a new study design structure, related to a new level of theory that goes beyond the current single-factor, a-theoretic epidemiological studies. This new platform for the design of large-scale Work/Stress/Disease studies would assess CVD-related disease mechanisms in a more general and dynamic form, based on the use of new tools for measuring autonomic functions in an occupational stress context and a new theory of disease causation. A sample outline is presented for such a study, based on Stress-Disequilibrium Theory (SDT) hypotheses, building on analytic tools developed for the assessment of stress-related exhaustion effects and chronic disease risks from Heart Rate Variability (HRV) research studies. The goal is to assess the associations between social organizational risks, particularly at work, and hypertension, metabolic syndrome, and diabetes II. The study design is multi-stage, spanning across several levels of disease-related de-regulation, and addressing co-morbidity of the conditions themselves. The study design is meant to span across a broad social population at all levels and would probably be multi-site, involving several countries, to yield the larger sample increased power for finding associations for work-physiological effects.
C1 [Karasek, Robert] Univ Massachusetts Lowell, Dept Work Environm, Lowell, MA 01854 USA.
   [Karasek, Robert] Univ Copenhagen, Dept Psychol, Copenhagen, Denmark.
   [Collins, Sean] Univ Massachusetts Lowell, Dept Phys Therapy, Lowell, MA USA.
   [Clays, Els] Univ Hosp, Dept Publ Hlth, Ghent, Belgium.
   [Bortkiewicz, Alicja] Nofer Inst Occupat Med, Dept Work Physiol & Ergon, Lodz, Poland.
   [Ferrario, Marco] Univ Insubria, Dept Expt & Clin Biomed Sci, Insubria, Varese, Italy.
C3 University of Massachusetts System; University of Massachusetts Lowell;
   University of Copenhagen; University of Massachusetts System; University
   of Massachusetts Lowell; Ghent University; Ghent University Hospital;
   Nofer Institute of Occupational Medicine; University of Insubria
RP Karasek, R (corresponding author), Univ Massachusetts Lowell, Dept Work Environm, Kitson Hall,1 Univ Ave, Lowell, MA 01854 USA.
EM Robert_Karasek@uml.edu
RI Ferrario, Marco/ABH-2115-2021; Bortkiewicz, Alicja/G-5513-2010
OI Ferrario, Marco M/0000-0003-2741-7124; Collins,
   Sean/0000-0002-7609-6219; Clays, Els/0000-0002-1092-945X; Bortkiewicz,
   Alicja/0000-0002-0042-4597
FU European Union [WND-POKL.02.03.01-00-001/08]
FX Alicja Bortkiewicz took part in this work within the confines of the
   project entitled: "Development of comprehensive projects for prevention
   of cardiovascular diseases" co-financed by the European Union under the
   European Social Fund: Human Capital Programme (project no.
   WND-POKL.02.03.01-00-001/08).
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NR 56
TC 16
Z9 27
U1 0
U2 12
PU NOFER INST OCCUPATIONAL MEDICINE, POLAND
PI LODZ
PA SW TERESY 8, LODZ, 91-348, POLAND
SN 1232-1087
EI 1896-494X
J9 INT J OCCUP MED ENV
JI Int. J. Occup. Med. Environ. Health
PY 2010
VL 23
IS 3
BP 293
EP 312
DI 10.2478/v10001-010-0035-2
PG 20
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA 718QF
UT WOS:000287139600008
PM 21306975
DA 2025-06-11
ER

PT J
AU Mariana, M
   Cairrao, E
AF Mariana, Melissa
   Cairrao, Elisa
TI Phthalates Implications in the Cardiovascular System
SO JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
LA English
DT Review
DE plastic contaminants; phthalates; cardiovascular system; blood pressure;
   atherosclerosis; cardiometabolic risk
ID INCREASED BLOOD-PRESSURE; BISPHENOL-A; ENDOTHELIAL DYSFUNCTION;
   BETA-THUJAPLICIN; IN-VITRO; CAROTID ATHEROSCLEROSIS; CARDIAC
   DEVELOPMENT; CIRCULATING LEVELS; MATERNAL EXPOSURE; OXIDATIVE STRESS
AB Today's sedentary lifestyle and eating habits have been implicated as some of the causes of the increased incidence of several diseases, including cancer and cardiovascular diseases. However, environmental pollutants have also been identified as another possible cause for this increase in recent decades. The constant human exposure to plastics has been raising attention regarding human health, particularly when it comes to phthalates. These are plasticizers used in the manufacture of industrial and consumer products, such as PVC (Polyvinyl Chloride) plastics and personal care products, with endocrine-disrupting properties, as they can bind molecular targets in the body and interfere with hormonal function. Since these compounds are not covalently bound to the plastic, they are easily released into the environment during their manufacture, use, or disposal, leading to increased human exposure and enhancing health risks. In fact, some studies have related phthalate exposure with cardiovascular health, having already shown a positive association with the development of hypertension and atherosclerosis in adults and some cardiometabolic risk factors in children and adolescents. Therefore, the main purpose of this review is to present and relate the most recent studies concerning the implications of phthalates effects on the cardiovascular system.
C1 [Mariana, Melissa; Cairrao, Elisa] Univ Beira Interior, Hlth Sci Res Ctr, CICS UBI, P-6200506 Covilha, Portugal.
   [Cairrao, Elisa] Univ Beira Interior, Fac Hlth Sci, FCS UBI, P-6200506 Covilha, Portugal.
C3 Universidade da Beira Interior; Universidade da Beira Interior
RP Cairrao, E (corresponding author), Univ Beira Interior, Hlth Sci Res Ctr, CICS UBI, P-6200506 Covilha, Portugal.; Cairrao, E (corresponding author), Univ Beira Interior, Fac Hlth Sci, FCS UBI, P-6200506 Covilha, Portugal.
EM melissa.r.mariana@gmail.com; ecairrao@fcsaude.ubi.pt
RI ; Cairrao, Elisa/AAB-1164-2020
OI Mariana, Melissa/0000-0003-1875-0144; Cairrao, Elisa/0000-0002-4823-5701
FU FEDER funds through the POCI -COMPETE 2020 -Operational Programme
   Competitiveness and Internationalisation in Axis I -Strengthening
   research, technological development and innovation
   [POCI-01-0145-FEDER007491]; FCT -Foundation for Science and Technology
   [UID/Multi/00709/2019]
FX This work was supported by FEDER funds through the POCI -COMPETE 2020
   -Operational Programme Competitiveness and Internationalisation in Axis
   I -Strengthening research, technological development and innovation
   (Project POCI-01-0145-FEDER007491) and National Funds by FCT -Foundation
   for Science and Technology (Project UID/Multi/00709/2019).
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NR 98
TC 67
Z9 69
U1 5
U2 33
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2308-3425
J9 J CARDIOVASC DEV DIS
JI J. Cardiovasc. Dev. Dis.
PD SEP
PY 2020
VL 7
IS 3
AR 26
DI 10.3390/jcdd7030026
PG 19
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA OB1DG
UT WOS:000578214700001
PM 32707888
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Taneja, SK
   Singh, KB
AF Taneja, Satish Kumar
   Singh, Kshetrimatyum Birla
TI Beneficial effects of modified egg on oxidative stress in
   F1-generation of metabolic syndrome-X induced Wistar rat
SO INDIAN JOURNAL OF EXPERIMENTAL BIOLOGY
LA English
DT Article
DE Cu; Diabetes mellitus; Omega-3 fatty acids; Mg; Mn; Modified egg;
   Oxidative stress; Vitamin-E; Zn
ID DENSITY LIPOPROTEIN-CHOLESTEROL; DEPENDENT DIABETES-MELLITUS; VITAMIN-E;
   ANTIOXIDANT STATUS; ZINC STATUS; ENZYMATIC DETERMINATION; SERUM
   TRIGLYCERIDES; DEFICIENT MICE; SUPPLEMENTATION; COPPER
AB Congenital malformations of neonates are one of the adverse effects of diabetic pregnancy which can be prevented by supplementation of vitamin E and C. The survived neonates usually are at higher risk to diabetes, hypertension, dyslipidemia and cardiovascular diseases that may possibly be prevented through antioxidants administration. In view of this information, the efficacy of modified poultry egg enriched with optimum minerals, vitamin E and omega-3 fatty acids was studied on F-1-generation, which were made to survive by feeding them this modified egg to diabetic mothers of Wistar rats. The survived F-1-generation displayed hyperglycemia, dyslipidemia and hypertension like their parents, evaluated after three months of the experiment. Their mineral status revealed a higher Zn and lower Cu, Mg and Mn levels in liver and kidney. Their lipid peroxidation products were however higher and the enzyme activities of superoxide dismutase, catalase, glutathione-S-transferase, glutathione reductase, glutathione (reduced) and glucose-6 phosphate dehydrogenase were significantly lower. In the other group of F-1-generation, fed modified egg mixed diet, a significant reduction in the blood pressure, serum glucose, serum lipid profile, and the lipid peroxidation products, and a significant increase in the activities of enzymes per se with reversal of Zn, Cu, Mg and Mn levels closer to the control group were recorded. The data suggest that the
C1 [Taneja, Satish Kumar; Singh, Kshetrimatyum Birla] Panjab Univ, Dept Zool, Chandigarh 160014, India.
C3 Panjab University
RP Taneja, SK (corresponding author), Panjab Univ, Dept Zool, Chandigarh 160014, India.
EM sktaneja@gmail.com
FU University Grants Commission, New Delhi
FX Thanks are due to Mr. Sandeep Barisal from Jaya Health Care Poultry Farm
   (Panchkula, Haryana, India) for providing the infrastructure to rear the
   birds. Financial aid provided by University Grants Commission, New Delhi
   under Special Assistance Programme, Phase-III to the Zoology Department
   and research fellowship to K. Birla Singh provided by UGC is gratefully
   acknowledged. It is certified that there is no conflicts of interest
   between the authors and the various funding agencies.
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NR 66
TC 5
Z9 5
U1 0
U2 4
PU NATL INST SCIENCE COMMUNICATION-NISCAIR
PI NEW DELHI
PA DR K S KRISHNAN MARG, PUSA CAMPUS, NEW DELHI 110 012, INDIA
SN 0019-5189
EI 0975-1009
J9 INDIAN J EXP BIOL
JI Indian J. Exp. Biol.
PD FEB
PY 2009
VL 47
IS 2
BP 104
EP 112
PG 9
WC Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics
GA 404HO
UT WOS:000263142500004
PM 19374165
DA 2025-06-11
ER

PT J
AU Shao, XZ
   Dai, HF
   Zhu, LL
AF Shao, Xiangzhi
   Dai, Huifang
   Zhu, Lielie
TI Correlation between estimated glucose disposal rate and diabetic
   depression: a population-based study
SO FRONTIERS IN PSYCHIATRY
LA English
DT Article
DE depression; insulin resistance; waist circumference; diabetes; estimated
   glucose disposal rate
ID INSULIN-RESISTANCE; COMORBID DEPRESSION; METABOLIC SYNDROME; TYPE-1;
   ASSOCIATION; INDEX; MORTALITY; MELLITUS; EVENTS; ADULTS
AB Background Emerging evidence has identified a correlation between depression and insulin resistance (IR). This study aims to explore the correlation between estimated glucose disposal rate (eGDR)-a noninvasive and practical measure of IR-and depression in patients with diabetes mellitus (DM).Methods In this cross-sectional study, the data from 3,080 adults aged 18 years old or older with DM obtained from NHANES 1999-2018 were analyzed. The correlation between eGDR and depression were examined through multivariate logistic regression, subgroup analyses, restricted cubic spline (RCS) analysis, and interaction tests. Additionally, mediation analysis was conducted to assess whether leukocytes and neutrophils could mediate the effects of eGDR on depression.Results Multivariate logistic regression and RCS analyses demonstrate that eGDR was negative linearly correlated with diabetic depression (OR= 0.89; 95% CI: 0.84, 0.95). Patients with DM in Q3 and Q4 of eGDR exhibited a reduced risk of 28% and 54%, respectively, in depression, compared to those in Q1. Subgroup analyses, stratified by variables such as gender, BMI, age, education level, and medical comorbidities, consistently showed a negative correlation. Mediation analysis further indicates that neutrophils and leukocytes accounted for 4.0% and 3.6% of the correlation between eGDR and depression, respectively.Conclusions The results of this study demonstrated a statistically significant inverse linear correlation between eGDR and the prevalence of depression in patients with DM, with leukocytes and neutrophils acting as mediating factors in this correlation.
C1 [Shao, Xiangzhi; Zhu, Lielie] Zhejiang Chinese Med Univ, Dept Rehabil, Wenzhou TCM Hosp, Wenzhou, Zhejiang, Peoples R China.
   [Dai, Huifang] Wenzhou Med Univ, Affiliated Hosp 2, Dept Endocrinol, Wenzhou, Zhejiang, Peoples R China.
   [Dai, Huifang] Wenzhou Med Univ, Yuying Childrens Hosp, Wenzhou, Zhejiang, Peoples R China.
C3 Zhejiang Chinese Medical University; Wenzhou Medical University; Wenzhou
   Medical University
RP Zhu, LL (corresponding author), Zhejiang Chinese Med Univ, Dept Rehabil, Wenzhou TCM Hosp, Wenzhou, Zhejiang, Peoples R China.
EM eillie@126.com
OI Zhu, Lielie/0000-0002-7263-3224
FX The author(s) declare that no financial support was received for the
   research and/or publication of this article.
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NR 50
TC 0
Z9 0
U1 1
U2 1
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-0640
J9 FRONT PSYCHIATRY
JI Front. Psychiatry
PD MAR 25
PY 2025
VL 16
AR 1507280
DI 10.3389/fpsyt.2025.1507280
PG 10
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 1BH2C
UT WOS:001460932800001
PM 40201064
OA gold
DA 2025-06-11
ER

PT J
AU Hansel, B
   Giral, P
   Nobecourt, E
   Chantepie, S
   Bruckert, E
   Chapman, MJ
   Kontush, A
AF Hansel, B
   Giral, P
   Nobecourt, E
   Chantepie, S
   Bruckert, E
   Chapman, MJ
   Kontush, A
TI Metabolic syndrome is associated with elevated oxidative stress and
   dysfunctional dense high-density lipoprotein particles displaying
   impaired antioxidative activity
SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Article
ID APOLIPOPROTEIN-A-I; DEPENDENT DIABETES-MELLITUS; INSULIN-RESISTANCE;
   ABNORMAL COMPOSITION; LDL OXIDATION; PLASMA LDL; INHIBITS 3; HDL;
   DISEASE; HYPERTRIGLYCERIDEMIA
AB A metabolic syndrome (MetS) phenotype is characterized by insulin-resistance, atherogenic dyslipidemia, oxidative stress, and elevated cardiovascular risk and frequently involves subnormal levels of high-density lipoprotein (HDL) cholesterol. We evaluated the capacity of physicochemically distinct HDL subfractions from MetS subjects to protect low-density lipoprotein against oxidative stress.
   MetS subjects presented an insulin-resistant phenotype, with central obesity and elevation in systolic blood pressure and plasma triglyceride, LDL-cholesterol, apolipoprotein B, glucose, and insulin levels. Systemic oxidative stress, assessed as plasma 8-isoprostanes, was significantly higher (3.7-fold) in MetS subjects ( n = 10) compared with nonobese normolipidemic controls ( n = 11). In MetS, small, dense HDL3a, 3b, and 3c subfractions possessed significantly lower specific antioxidative activity ( up to - 23%, on a unit particle mass basis) than their counterparts in controls. In addition, HDL2a and 3a subfractions from MetS patients possessed lower total antioxidative activity ( up to - 41%, at equivalent plasma concentrations). The attenuated antioxidative activity of small, dense HDL subfractions correlated with systemic oxidative stress and insulin resistance and was associated with HDL particles exhibiting altered physicochemical properties ( core triglyceride enrichment and cholesteryl ester depletion).
   We conclude that antioxidative activity of small, dense HDL subfractions of altered chemical composition is impaired in MetS and associated with elevated oxidative stress and insulin resistance. Induction of selective increase in the circulating concentrations of dense HDL subfractions may represent an innovative therapeutic approach for the attenuation of high cardiovascular risk in MetS.
C1 Hop La Pitie Salpetriere, INSERM, Natl Inst Hlth & Med Res, Dyslipoprot & Atherosclerosis Res Unit, F-75013 Paris, France.
   Hop La Pitie Salpetriere, Serv Endocrinol Metab, F-75013 Paris, France.
C3 Sorbonne Universite; Assistance Publique Hopitaux Paris (APHP); Hopital
   Universitaire Pitie-Salpetriere - APHP; Institut National de la Sante et
   de la Recherche Medicale (Inserm); Sorbonne Universite; Assistance
   Publique Hopitaux Paris (APHP); Hopital Universitaire Pitie-Salpetriere
   - APHP
RP Kontush, A (corresponding author), Hop La Pitie Salpetriere, INSERM, U551, Pavillon Benjamin Delessert,83 Blvd Hop, F-75651 Paris 13, France.
EM kontush@chups.jussieu.fr
RI Kontush, Anatol/J-2198-2016; chapman, john/Y-2742-2019
OI CHANTEPIE-LABORDE, Sandrine/0000-0003-1652-432X; Kontush,
   Anatol/0000-0002-9008-7335
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NR 51
TC 348
Z9 398
U1 0
U2 6
PU ENDOCRINE SOC
PI CHEVY CHASE
PA 8401 CONNECTICUT AVE, SUITE 900, CHEVY CHASE, MD 20815-5817 USA
SN 0021-972X
J9 J CLIN ENDOCR METAB
JI J. Clin. Endocrinol. Metab.
PD OCT
PY 2004
VL 89
IS 10
BP 4963
EP 4971
DI 10.1210/jc.2004-0305
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 860EW
UT WOS:000224326300029
PM 15472192
OA Bronze
DA 2025-06-11
ER

PT J
AU Geraets, AFJ
   Koehler, S
   Schram, MT
AF Geraets, Anouk F. J.
   Koehler, Sebastian
   Schram, Miranda T.
TI Vascular and metabolic risk factors of late-life depression
SO VESSEL PLUS
LA English
DT Review
DE Depression; etiology; cerebral small vessel disease; microvascular
   dysfunction; metabolic syndrome; diabetes; inflammation;
   neurodegeneration
ID SMALL VESSEL DISEASE; C-REACTIVE PROTEIN; LOW-GRADE INFLAMMATION;
   GENERAL ELDERLY POPULATION; MICROVASCULAR DYSFUNCTION; ENDOTHELIAL
   DYSFUNCTION; BRAIN CHANGES; LATE-ONSET; ASSOCIATION; SYMPTOMS
AB Late-life depression (LLD) is a common complex mood disorder with high comorbidity of both psychiatric and physical diseases, cognitive decline, and increased mortality. The mechanisms underlying LLD are incompletely understood. The heterogeneity of depression complicates research into the underlying mechanisms, and factors involved in LLD may differ from those involved in early-life depression. This narrative review provides an overview of (micro-)vascular and metabolic factors involved in the development of LLD. Evidence suggests that cerebral small vessel disease, generalized microvascular dysfunction, and metabolic risk factors, including diabetes and inflammation, may contribute to the development of LLD, while the role of neurodegeneration needs further indepth investigation. Accordingly, vascular and metabolic factors may provide promising targets for the prevention and improvement of treatment of LLD. Guidelines to screen for LLD in cardiovascular care need further implementation, as do integrated care approaches that treat LLD and diabetes jointly. However, intervention studies are needed to assess which interventions are appropriate and most effective in clinical practice.
C1 [Geraets, Anouk F. J.; Koehler, Sebastian; Schram, Miranda T.] Maastricht Univ, Med Ctr MUMC, Peter Debyelaan 25, NL-6229 HX Maastricht, Netherlands.
C3 Maastricht University; Maastricht University Medical Centre (MUMC)
RP Schram, MT (corresponding author), Maastricht Univ, Med Ctr MUMC, Dept Med, Maastricht Study, Randwycksingel 35, NL-6229 EG Maastricht, Netherlands.
EM m.schram@maastrichtuniversity.nl
RI Geraets, Anouk/ACI-9551-2022
OI Geraets, Anouk/0000-0002-2648-4424
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NR 93
TC 4
Z9 4
U1 0
U2 0
PU OAE PUBLISHING INC
PI ALHAMBRA
PA 245 E MAIN ST, ST122, ALHAMBRA, CA 91801 USA
EI 2574-1209
J9 VESSEL PLUS
JI Vessel Plus
PY 2022
VL 6
AR 19
DI 10.20517/2574-1209.2021.102
PG 11
WC Cardiac & Cardiovascular Systems
WE Emerging Sources Citation Index (ESCI)
SC Cardiovascular System & Cardiology
GA T0F7U
UT WOS:001401877700001
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Mokwatsi, GG
   Schutte, AE
   Kruger, R
AF Mokwatsi, Gontse G.
   Schutte, Aletta E.
   Kruger, Ruan
TI A biomarker of tissue damage, lactate dehydrogenase, is associated with
   fibulin-1 and oxidative stress in blacks: the SAfrEIC study
SO BIOMARKERS
LA English
DT Article
DE sex; extracellular matrix remodeling; tissue damage; ethnicity;
   Cardiovascular disease
ID EXTRACELLULAR-MATRIX ALTERATIONS; BLOOD-PRESSURE; HYPERTENSION;
   AFRICANS; MARKERS
AB Context: Extracellular matrix (ECM) remodeling and oxidative stress is present in hypertension and associated arterial stiffness, but little is known on the physiological link among lactate dehydrogenase (LDH), fibulin-1, and reactive oxygen species (ROS).
   Objective: The objective of this study is to explore the link among a marker of tissue damage (LDH), fibulin-1 (as ECM biomarker), and ROS.
   Methods: We included 316 black and 305 white South Africans and determined the above-mentioned biomarkers along with additional cardiometabolic risk factors.
   Results: LDH associated positively with fibulin-1 (beta = 0.23; p < 0.001) and ROS (beta = 0.11; p = 0.30) in blacks only.
   Conclusion: Our finding suggests that increased circulating levels of LDH may be due to early ECM remodeling and oxidative stress in blacks that are subjected to detrimental and uncontrolled lifestyle risk factors.
C1 [Mokwatsi, Gontse G.; Schutte, Aletta E.; Kruger, Ruan] North West Univ, HART, ZA-2531 Potchefstroom, South Africa.
   [Schutte, Aletta E.] North West Univ, MRC, Fac Hlth Sci, Res Unit Hypertens & Cardiovasc, ZA-2531 Potchefstroom, South Africa.
C3 North West University - South Africa; North West University - South
   Africa
RP Kruger, R (corresponding author), North West Univ, HART, ZA-2531 Potchefstroom, South Africa.
EM ruan.kruger@nwu.ac.za
RI Mokwatsi, Gontse/AFI-8210-2022; Schutte, Aletta/E-5126-2018; Kruger,
   Ruan/N-7618-2015
OI Schutte, Aletta/0000-0001-9217-4937; Kruger, Ruan/0000-0001-7680-2032;
   Mokwatsi, Gontse/0000-0001-6203-3965
FU South African National Research Foundation (NRF) [GUN 2073040];
   North-West University, Potchefstroom, South Africa; Human Research
   Ethics Council of the North-West University [NWU-00038-14-S1]
FX The authors report that they have no conflicts of interest. The authors
   would also like to thank the South African National Research Foundation
   (NRF) [GUN 2073040] and the North-West University, Potchefstroom, South
   Africa. The SAfrEIC study was granted ethics approval from the Human
   Research Ethics Council of the North-West University (NWU-00038-14-S1).
   The authors have nothing to disclose.
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NR 35
TC 13
Z9 17
U1 0
U2 8
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1354-750X
EI 1366-5804
J9 BIOMARKERS
JI Biomarkers
PD JAN 2
PY 2016
VL 21
IS 1
BP 48
EP 55
DI 10.3109/1354750X.2015.1118532
PG 8
WC Biotechnology & Applied Microbiology; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Toxicology
GA DI8FN
UT WOS:000373737000002
PM 26631026
DA 2025-06-11
ER

PT J
AU Ibraheem, ZO
   Basir, R
   Aljobory, AK
   Ibrahim, OE
   Alsumaidaee, A
   Yam, MF
AF Ibraheem, Zaid O.
   Basir, Rusliza
   Aljobory, Ahmad Kh.
   Ibrahim, Omar E.
   Alsumaidaee, Ajwad
   Yam, Mun Fee
TI Impact of Gentamicin Coadministration along with High Fructose Feeding
   on Progression of Renal Failure and Metabolic Syndrome in Sprague-Dawley
   Rats
SO BIOMED RESEARCH INTERNATIONAL
LA English
DT Article
ID INSULIN-RESISTANCE; SODIUM-REABSORPTION; LIVER; NEPHROTOXICITY; ALPHA;
   AMINOGLYCOSIDES; TRIGLYCERIDE; MECHANISM; EXCRETION; STRESS
AB The current study evaluates the impact of high fructose feeding in rat model of gentamicin induced nephrotoxicity. Sprague-Dawley rats weighing 180-200 g were randomized into four groups; (C) received standard rodents chow with free access to ad libitum drinking water for 8 weeks and was considered as control, (F) received standard rodents chow with free access to drinking water supplemented with 20% (W/V) fructose for the same abovementioned period, (FG) was fed as group F and was given 80 mg/kg (bodyweight)/day gentamicin sulphate intraperitoneally during the last 20 days of the feeding period, and (G) was given gentamicin as above and fed as group C. Renal function was assessed at the end of the treatment period through measuring serum creatinine, uric acid and albumin, creatinine clearance, absolute and fractional excretion of both sodium and potassium, twenty-four-hour urinary excretion of albumin, and renal histology. For metabolic syndrome assessment, fasting plasma glucose and insulin were measured and oral glucose tolerance test was performed throughout the treatment period. Results showed that gentamicin enhances progression of fructose induced metabolic syndrome. On the other hand, fructose pretreatment before gentamicin injection produced a comparable degree of renal dysfunction to those which were given fructose-free water but the picture of nephrotoxicity was somewhat altered as it was characterized by higher extent of glomerular congestion and protein urea. Overall, more vigilance is required when nephrotoxic drugs are prescribed for patients with fructose induced metabolic syndrome.
C1 [Ibraheem, Zaid O.; Basir, Rusliza; Yam, Mun Fee] Univ Putra Malaysia, Sch Med & Hlth Sci, Dept Pharmacol & Toxicol, Serdang 47300, Selangor, Malaysia.
   [Ibraheem, Zaid O.; Alsumaidaee, Ajwad] Univ Baghdad, Fac Pharm, Dept Clin Lab Sci, Baghdad, Iraq.
   [Basir, Rusliza] Univ Putra Malaysia, Sch Med & Hlth Sci, Dept Anat, Serdang 47300, Selangor, Malaysia.
   [Aljobory, Ahmad Kh.; Alsumaidaee, Ajwad] Univ Putra Malaysia, Sch Vet Med, Dept Vet Surg, Serdang 47300, Selangor, Malaysia.
   [Ibrahim, Omar E.] Univ Putra Malaysia, Sch Med & Hlth Sci, Dept Pathol, Serdang 47300, Selangor, Malaysia.
   [Ibrahim, Omar E.] Univ Teknol MARA, Sch Dent, Dept Pathol, Shah Alam 48600, Selangor, Malaysia.
C3 Universiti Putra Malaysia; University of Baghdad; Universiti Putra
   Malaysia; Universiti Putra Malaysia; Universiti Putra Malaysia;
   Universiti Teknologi MARA
RP Ibraheem, ZO (corresponding author), Univ Putra Malaysia, Sch Med & Hlth Sci, Dept Pharmacol & Toxicol, Serdang 47300, Selangor, Malaysia.
EM zaid.2002.2005@gmail.com; rusliza@medic.upm.my
RI Ibraheem, zaid/P-9442-2019; Basir, Rusliza/AAP-4070-2021; Yam,
   Mun/E-2862-2012; ibrahim, omar/AGQ-3749-2022
OI Ibrahim, Associate Professor Dr Omar Emad/0000-0001-8200-9727; Basir,
   Rusliza/0000-0003-3363-6630
FU School of medicine and health science/Universiti Putra Malaysia
FX School of medicine and health science/Universiti Putra Malaysia, is
   gratefully acknowledged for financial support.
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NR 31
TC 13
Z9 14
U1 0
U2 3
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2314-6133
EI 2314-6141
J9 BIOMED RES INT
JI Biomed Res. Int.
PY 2014
VL 2014
AR 823879
DI 10.1155/2014/823879
PG 10
WC Biotechnology & Applied Microbiology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Research & Experimental Medicine
GA AK7QZ
UT WOS:000338624100001
PM 25045706
OA Green Submitted, Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Raeder, MB
   Bjelland, I
   Vollset, SE
   Steen, VM
AF Raeder, Maria B.
   Bjelland, Ingvar
   Vollset, Stein Emil
   Steen, Vidar M.
TI Obesity, dyslipidemia, and diabetes with selective serotonin reuptake
   inhibitors: The Hordaland Health Study
SO JOURNAL OF CLINICAL PSYCHIATRY
LA English
DT Article
ID DRUGS ACTIVATE SREBP; ANTIDEPRESSANT-DRUGS; DEPRESSIVE SYMPTOMS;
   ANTIPSYCHOTIC-DRUGS; MAJOR DEPRESSION; HOSPITAL ANXIETY; PLASMA-LIPIDS;
   SERUM-LIPIDS; CHOLESTEROL; PREVALENCE
AB Objective: This study aimed to examine whether subjects taking selective serotonin reuptake inhibitors (SSRIs) are more likely to have elements of the metabolic syndrome compared with those taking no psychotropic drugs. For comparison, we also studied subjects taking antipsychotic drugs.
   Method: We used data from The Hordaland Health Study '97-'99, a general community cross-sectional health survey including 25,315 subjects aged 40 to 49 and 70 to 74 years. For the groups studied, we estimated prevalence and odds ratios (ORs) for obesity, hypercholesterolemia, low high-density lipoprotein cholesterol, hypertriglyceridemia, and diabetes.
   Results: We observed an association between use of SSRIs as a group (N = 461) and abdominal obesity (OR = 1.40, 95% CI = 1.08 to 1.81) and hypercholesterolemia (OR = 1.36, 95% CI = 1.07 to 1.73) after adjusting for multiple possible confounders. There was also a trend toward an association between SSRI use and diabetes. In a subgroup analysis of subjects taking SSRIs, the use of paroxetine (N = 187) was markedly associated with both general and abdominal obesity but not with hypercholesterolemia. In contrast, the use of citalopram (N = 142) was not associated with any of the metabolic outcome variables, while the use of any other SSRI (sertraline, fluoxetine, or fluvoxamine) (N = 131) as a mixed subgroup was associated with both abdominal obesity and hypercholesterolemia. We also replicated the previously reported associations between use of antipsychotics and obesity and metabolic disturbances.
   Conclusion: We have shown that use of at least some SSRIs is associated with clinical and biochemical elements of the metabolic syndrome. Our data indicate differences in the metabolic side effect profile among various SSRI drugs, although treatment bias might have influenced these results. We suggest that patients taking SSRIs be carefully monitored for obesity and dyslipidemia.
C1 Haukeland Hosp, Ctr Med Genet & Mol Med, Dr Einar Martens Res Grp Biol Psychiat, Helse Bergen HF, N-5021 Bergen, Norway.
   Univ Bergen, Dept Clin Med, Bergen, Norway.
   Univ Bergen, Bergen Mental Hlth Res Ctr, Bergen, Norway.
   Haukeland Hosp, Dept Child & Adolescent Mental Hlth Serv, N-5021 Bergen, Norway.
   Univ Bergen, Dept Publ Hlth & Primary Care, Sect Epidemiol & Med Stat, Bergen, Norway.
C3 University of Bergen; Haukeland University Hospital; University of
   Bergen; University of Bergen; University of Bergen; Haukeland University
   Hospital; University of Bergen
RP Raeder, MB (corresponding author), Haukeland Hosp, Ctr Med Genet & Mol Med, Dr Einar Martens Res Grp Biol Psychiat, Helse Bergen HF, N-5021 Bergen, Norway.
EM maria.rader@uib.no
RI Abebe, Mesfin/GPF-5732-2022; Steen, Vidar/A-6190-2008
OI Bjelland, Ingvar/0000-0003-1113-8323
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NR 38
TC 149
Z9 160
U1 2
U2 16
PU PHYSICIANS POSTGRADUATE PRESS
PI MEMPHIS
PA P O BOX 752870, MEMPHIS, TN 38175-2870 USA
SN 0160-6689
EI 1555-2101
J9 J CLIN PSYCHIAT
JI J. Clin. Psychiatry
PD DEC
PY 2006
VL 67
IS 12
BP 1974
EP 1982
DI 10.4088/JCP.v67n1219
PG 9
WC Psychology, Clinical; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA 120LI
UT WOS:000243085800018
PM 17194277
DA 2025-06-11
ER

PT J
AU Baysal, T
   Alp, H
   Koç, N
   Atabek, ME
   Eklioglu, BS
   Karaarslan, S
AF Baysal, Tamer
   Alp, Hayrullah
   Koc, Nesibe
   Atabek, Mehmet Emre
   Eklioglu, Beray Selver
   Karaarslan, Sevim
TI Serum ischemia-modified albumin level and its association with
   cardiovascular risk factors in obese children and adolescents
SO JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
LA English
DT Article
DE cardiovascular risk; children and adolescents; epicardial adipose
   tissue; hepatosteotosis; ischemia modified albumin; metabolic syndrome
ID EPICARDIAL ADIPOSE-TISSUE; TYPE-2 DIABETES-MELLITUS; LEFT-VENTRICULAR
   MASS; METABOLIC SYNDROME; OXIDATIVE STRESS; BIOMARKERS; DISEASE; MARKER;
   LIPIDS; INDEX
AB Background: Serum ischemia modified albumin (IMA) levels have been previously studied and found to correlate with some anthropometric and laboratory measurements in adult obesity. IMA had not been studied in obese children and adolescents.
   Objective: The aim of the study is to analyze serum IMA levels and to evaluate their correlation with cardiovascular risk factors in obese children and adolescents with and without metabolic syndrome (MS).
   Subjects and methods: Sixty-one obese children/adolescents and 33 healthy children were included in the study. The obese group was divided into four subgroups, including MS (n=25), non-MS (n=36), liver steatosis (n=19) and non-liver steatosis (n=42) groups. Blood was collected to analyze biochemical parameters and IMA. Epicardial adipose tissue thickness was measured with echocardiography, and liver steotosis was determined with ultrasonography for each subject.
   Results: Body mass index (BMI), waist circumferences (WC), left ventricular mass (LVM) and epicardial adipose tissue (EAT) thickness were significantly higher in obese subjects. Serum IMA levels were significantly higher in the metabolic syndrome (MS) and hepatosteotosis groups. Additionally, LVM and EAT thickness were found to be correlated with serum IMA levels in these groups.
   Conclusions: Our study suggests that serum IMA levels may be used to predict cardiovascular risk in obese children with MS and hepatosteotosis. This may be related to the duration of obesity in childhood ending in adulthood.
C1 [Baysal, Tamer; Alp, Hayrullah; Koc, Nesibe; Karaarslan, Sevim] Necmettin Erbakan Univ, Dept Pediat Cardiol, Meram Sch Med Hosp, Konya, Turkey.
   [Atabek, Mehmet Emre; Eklioglu, Beray Selver] Necmettin Erbakan Univ, Dept Pediat Endocrinol, Meram Sch Med Hosp, Konya, Turkey.
C3 Necmettin Erbakan University; Necmettin Erbakan University
RP Alp, H (corresponding author), Necmettin Erbakan Univ, Dept Pediat Cardiol, Meram Sch Med Hosp, Konya, Turkey.
EM drhayrullahalp@hotmail.com
RI RAYMAN ERGÜN, Ahsen/AGF-6627-2022; Alp, Hayrullah/D-2984-2014; Eren,
   Mehmet/LBI-2705-2024
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NR 31
TC 11
Z9 11
U1 0
U2 10
PU WALTER DE GRUYTER GMBH
PI BERLIN
PA GENTHINER STRASSE 13, D-10785 BERLIN, GERMANY
SN 0334-018X
J9 J PEDIATR ENDOCR MET
JI J. Pediatr. Endocrinol. Metab.
PD OCT
PY 2012
VL 25
IS 9-10
BP 935
EP 944
DI 10.1515/jpem-2012-0191
PG 10
WC Endocrinology & Metabolism; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Pediatrics
GA 019RP
UT WOS:000309757300019
PM 23426823
DA 2025-06-11
ER

PT J
AU Sakamoto, K
   Sakamoto, T
   Ogawa, H
AF Sakamoto, Kenji
   Sakamoto, Tomohiro
   Ogawa, Hisao
TI Effects of metabolic risk factors on production of plasminogen activator
   inhibitor-1 and adiponectin by adipocytes
SO CIRCULATION JOURNAL
LA English
DT Article
DE adiponectin; metabolic syndrome; type 1 plasminogen activator inhibitor
   (PAI-1)
ID OXIDATIVE STRESS; EXPRESSION; OBESITY; DISEASE
AB Background Type 1 plasminogen activator inhibitor (PAI-1) and adiponectin are produced by adipocytes and are important in the progression of coronary artery disease (CAD).
   Methods and Results Different concentrations of glucose, insulin and 1% triglycerides were used to assay PAI-1 and adiponectin production from cultured adipocytes. Triglycerides induced the highest PAI-1 production with 16.5 mmol/L glucose and 50 nmol/L insulin. In contrast, glucose and insulin decreased adiponectin production in a dose-dependent manner irrespective of triglycerides.
   Conclusion The metabolic syndrome risk factors alter PAI-1 and adiponectin production by adipocytes, in the presence or absence of triglycerides, which might play a role in the development of CAD.
C1 [Sakamoto, Tomohiro] Saiseikai Kumamoto Hosp, Ctr Cardiovasc, Div Cardiol, Kumamoto 8614193, Japan.
   [Sakamoto, Kenji] Hlth Insurance Yatsushiro Gen Hosp, Div Cardiol, Yatsushiro, Japan.
   [Ogawa, Hisao] Kumamoto Univ, Dept Cardiovasc Med, Grad Sch Med Sci, Kumamoto, Japan.
C3 Saiseikai Kumamoto Hospital; Kumamoto University
RP Sakamoto, T (corresponding author), Saiseikai Kumamoto Hosp, Ctr Cardiovasc, Div Cardiol, 5-3-1 Chikami, Kumamoto 8614193, Japan.
EM tom@kumamoto-u.ac.jp
OI Sakamoto, Kenji/0000-0003-4076-8981
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NR 10
TC 14
Z9 14
U1 0
U2 0
PU JAPANESE CIRCULATION SOC
PI TOYKO
PA 18TH FLOOR IMPERIAL HOTEL TOWER, 1-1-1 UCHISAIWAI-CHO CHIYODA-KU, TOYKO,
   100-0011, JAPAN
SN 1346-9843
EI 1347-4820
J9 CIRC J
JI Circ. J.
PD MAY
PY 2008
VL 72
IS 5
BP 844
EP 846
DI 10.1253/circj.72.844
PG 3
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 294WM
UT WOS:000255437000026
PM 18441469
OA Bronze
DA 2025-06-11
ER

PT J
AU Salvo, A
   Tuttolomondo, A
AF Salvo, Andrea
   Tuttolomondo, Antonino
TI The Role of Olive Oil in Cardiometabolic Risk
SO METABOLITES
LA English
DT Review
DE olive oil; cardiovascular disease; Mediterranean diet
ID TYPE-2 DIABETES-MELLITUS; REDUCES OXIDATIVE STRESS; MEDITERRANEAN DIET;
   PHENOLIC-COMPOUNDS; BLOOD-PRESSURE; PLATELET ACTIVATION; ADIPOSE-TISSUE;
   ALPHA-AMYLASE; NITRIC-OXIDE; IN-VITRO
AB Olive oil, the primary fat source in the Mediterranean diet (MedDiet), is rich in monounsaturated fatty acids (MUFA), especially oleic acid, which constitutes 70-80% of its composition. Extra-virgin olive oil (EVOO), produced by mechanically pressing olives, is the highest quality olive oil, with an intense flavor and acidity <1%. In contrast, refined olive oil (ROO), a blend of virgin and refined oils, contains fewer antioxidants and anti-inflammatory compounds. EVOO's health benefits stem largely from its MUFA content, which is linked to reduced risks of cardiovascular disease (CVD), neurodegenerative conditions, and certain cancers. Additionally, EVOO contains minor, but bioactive, components such as polyphenols, tocopherols, and phytosterols, contributing to its oxidative stability, sensory qualities, and health-promoting properties. These include polyphenols, like oleuropein, hydroxytyrosol, and tyrosol, which exhibit anti-inflammatory, cardioprotective, neuroprotective, and anticancer effects. Epidemiological studies suggest an inverse relationship between olive oil intake and CVD, with EVOO-enriched MedDiet interventions showing improved lipid profiles, reduced blood pressure, and lower cardiovascular event risk. The PREDIMED study highlights the significant role of EVOO in reducing cardiometabolic risk. This review explores the impact of EVOO's chemical components within the MedDiet framework on metabolic variables influencing cardiometabolic health.
C1 [Salvo, Andrea; Tuttolomondo, Antonino] Policlin P Giaccone, Internal Med & Stroke Care Ward, Piazza Cliniche 2, I-90127 Palermo, Italy.
   [Salvo, Andrea; Tuttolomondo, Antonino] Univ Palermo, PROMISE Dept, I-90127 Palermo, Italy.
C3 University of Palermo
RP Tuttolomondo, A (corresponding author), Policlin P Giaccone, Internal Med & Stroke Care Ward, Piazza Cliniche 2, I-90127 Palermo, Italy.; Tuttolomondo, A (corresponding author), Univ Palermo, PROMISE Dept, I-90127 Palermo, Italy.
EM andrea.salvo996@gmail.com; bruno.tuttolomondo@unipa.it
OI Tuttolomondo, Antonino/0000-0001-6440-7318
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NR 175
TC 2
Z9 2
U1 4
U2 4
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2218-1989
J9 METABOLITES
JI Metabolites
PD MAR 11
PY 2025
VL 15
IS 3
AR 190
DI 10.3390/metabo15030190
PG 27
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 0RB8B
UT WOS:001453998000001
PM 40137153
OA gold
DA 2025-06-11
ER

PT J
AU Omar, JS
   Jaradat, N
   Qadoumi, M
   Qadoumi, AN
AF Omar, Jamal Shaker
   Jaradat, Nidal
   Qadoumi, Mohammad
   Qadoumi, Abdel Naser
TI Regular swimming exercise improves metabolic syndrome risk factors: a
   quasi-experimental study
SO BMC SPORTS SCIENCE MEDICINE AND REHABILITATION
LA English
DT Article
DE Swimming sessions; Metabolic risk factors; Body fat percent; Palestine
ID BLOOD-PRESSURE; PHYSICAL-ACTIVITY; HYPERTENSION; INDIVIDUALS;
   DEPRESSION; RESISTANCE; ANXIETY
AB Background In the past few decades, swimming became one of the most important physical activities within the health system and is considered a practical nonpharmacological approach to managing of type 2 diabetes (T2DM), hyperlipidemia, hypertension (HTN), and obesity. The current study aimed to assess the effect of long-term swimming sessions on glycemic and lipidemic parameters, hemodynamic responses, body fat percent, and body mass index for patients with metabolic risk factors from Palestine. Methods Forty participants from both genders with T2DM and HTN (aged 52.4 +/- 5.5 yrs) agreed to participate in this quasi-experimental study and were divided into two groups. The first group included the participants who performed long-term swimming sessions and the second group served as the control. The first group exercised for 2 h, 3 times/week in 29-33 degrees C swimming pool temperature for 16 weeks. Simultaneously, the control group did not participate in any exercise and advised them to keep on with their everyday lifestyle. All the obtained metabolic syndrome risk factors data were analyzed using a two-way ANOVA analysis of variance (2*2) which was applied to determine the differences according group, time, and interaction. Results The results showed that there were statistically significant differences at p < 0.05 in the variables of Total Cholesterol (TC), High Density of Lipoprotein (HDL), Low Density of Lipoprotein (LDL), Triglycerides (TG), Blood Glucose (BG), Systolic Blood Pressure (SBP), Diastolic Blood Pressure (DBP), Body Mass Index (BMI), and body fat percent according to group, time, and interaction for the experimental group. Conclusions The findings of the current study suggested that the regular 16 weeks of swimming sessions could be considered nonpharmacological approaches in managing T2DM and HTN.
C1 [Omar, Jamal Shaker; Qadoumi, Mohammad; Qadoumi, Abdel Naser] An Najah Natl Univ, Dept Phys Educ, Nablus 00970, Palestine.
   [Jaradat, Nidal] An Najah Natl Univ, Fac Med & Hlth Sci, Dept Pharm, Nablus 00970, Palestine.
C3 An Najah National University; An Najah National University
RP Jaradat, N (corresponding author), An Najah Natl Univ, Fac Med & Hlth Sci, Dept Pharm, Nablus 00970, Palestine.
EM nidaljaradat@najah.edu
RI Jaradat, Nidal/I-3136-2016
FU An-Najah National University [ANNU-1920-So023]
FX This research was funded by An-Najah National University, grant number
   ANNU-1920-So023.
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NR 39
TC 14
Z9 15
U1 2
U2 6
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 2052-1847
J9 BMC SPORTS SCI MED R
JI BMC Sports Sci. Med. Rehabil.
PD MAR 8
PY 2021
VL 13
IS 1
AR 22
DI 10.1186/s13102-021-00254-8
PG 7
WC Rehabilitation; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Rehabilitation; Sport Sciences
GA QT5YP
UT WOS:000626663600001
PM 33685505
OA gold, Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Karuga, FF
   Jaromirska, J
   Malicki, M
   Sochal, M
   Szmyd, B
   Bialasiewicz, P
   Strzelecki, D
   Gabryelska, A
AF Karuga, Filip Franciszek
   Jaromirska, Julia
   Malicki, Mikolaj
   Sochal, Marcin
   Szmyd, Bartosz
   Bialasiewicz, Piotr
   Strzelecki, Dominik
   Gabryelska, Agata
TI The role of microRNAs in pathophysiology and diagnostics of metabolic
   complications in obstructive sleep apnea patients
SO FRONTIERS IN MOLECULAR NEUROSCIENCE
LA English
DT Review
DE microRNA; OSA; obstructive sleep apnea; diabetes; metabolic syndrome;
   metabolic complications
ID POSITIVE AIRWAY PRESSURE; DIABETIC FOOT ULCERS; INTERMITTENT HYPOXIA;
   DOWN-REGULATION; INSULIN-RESISTANCE; OXIDATIVE STRESS; AMERICAN ACADEMY;
   TNF-ALPHA; SIRTUIN 1; EXPRESSION
AB Obstructive sleep apnea (OSA) is one of the most common sleep disorders, which is characterized by recurrent apneas and/or hypopneas occurring during sleep due to upper airway obstruction. Among a variety of health consequences, OSA patients are particularly susceptible to developing metabolic complications, such as metabolic syndrome and diabetes mellitus type 2. MicroRNAs (miRNAs) as epigenetic modulators are promising particles in both understanding the pathophysiology of OSA and the prediction of OSA complications. This review describes the role of miRNAs in the development of OSA-associated metabolic complications. Moreover, it summarizes the usefulness of miRNAs as biomarkers in predicting the aforementioned OSA complications.
C1 [Karuga, Filip Franciszek; Jaromirska, Julia; Malicki, Mikolaj; Sochal, Marcin; Bialasiewicz, Piotr; Gabryelska, Agata] Med Univ Lodz, Dept Sleep Med & Metab Disorders, Lodz, Poland.
   [Szmyd, Bartosz] Med Univ Lodz, Barlicki Univ Hosp, Dept Neurosurg & Neurooncol, Lodz, Poland.
   [Szmyd, Bartosz] Med Univ Lodz, Dept Pediat Oncol & Hematol, Lodz, Poland.
   [Strzelecki, Dominik] Med Univ Lodz, Dept Affect & Psychot Disorders, Lodz, Poland.
C3 Medical University Lodz; Medical University Lodz; Medical University
   Lodz; Medical University Lodz
RP Karuga, FF; Gabryelska, A (corresponding author), Med Univ Lodz, Dept Sleep Med & Metab Disorders, Lodz, Poland.
EM filip.karuga@gmail.com; agata.gabryelska@gmail.com
RI Strzelecki, Dominik/S-9340-2016; Szmyd, Bartosz/AAM-8025-2021
OI Strzelecki, Dominik/0000-0002-8559-1078; Bialasiewicz,
   Piotr/0000-0002-8338-1747; Szmyd, Bartosz/0000-0002-4051-0887; Karuga,
   Filip/0000-0002-6551-6804
FU National Science Centre, Poland, Preludium 20 [2021/41/N/NZ5/00486]
FX The study was supported by National Science Centre, Poland, Preludium 20
   grant no. 2021/41/N/NZ5/00486 (for FFK).
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NR 176
TC 3
Z9 4
U1 0
U2 6
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1662-5099
J9 FRONT MOL NEUROSCI
JI Front. Molec. Neurosci.
PD JUL 21
PY 2023
VL 16
AR 1208886
DI 10.3389/fnmol.2023.1208886
PG 12
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA O1ZG2
UT WOS:001041865300001
PM 37547923
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Ke, ZL
   Tan, S
   Li, HY
   Jiang, SS
   Li, YP
   Chen, R
   Li, MX
AF Ke, Zunli
   Tan, Si
   Li, Haiyang
   Jiang, Shanshan
   Li, Yuping
   Chen, Rui
   Li, Mingxia
TI Tangeretin improves hepatic steatosis and oxidative stress through the
   Nrf2 pathway in high fat diet-induced nonalcoholic fatty liver disease
   mice
SO FOOD & FUNCTION
LA English
DT Article
ID INSULIN-RESISTANCE
AB Nonalcoholic liver disease (NAFLD) is a pathological condition characterized by excessive fat deposition in the liver, and NAFLD usually has a close relationship with obesity or metabolic syndrome. Currently, oxidative stress is considered as an important risk factor in the progression of NAFLD, therefore, effective amelioration of oxidative stress has emerged as a promising way to improve NAFLD. Tangeretin is a natural compound having various pharmacological activities including antioxidation and hepatoprotection. However, whether tangeretin is able to improve NAFLD through reducing hepatic oxidative stress is rarely reported. In our work, the preventive effects of tangeretin on a NAFLD mouse model induced by a high fat (HF) diet were studied. The results exhibited that tangeretin supplementation observably slowed down NAFLD progression through alleviation of metabolic indexes such as glucose tolerance, serum lipid levels and inflammatory factors, hepatic oxidative stress as well as steatosis. qRT-PCR showed that tangeretin supplementation increased the nuclear factor erythroid-2-related factor 2 (Nrf2) expression and then upregulated the expression of its downstream factors including HO-1, GCLC, NQO1 and GSTA2. Furthermore, the expression of the hepatic nucleus, Nrf2, HO-1 and GCLC, was also seen to be significantly enhanced in WB analysis. Taken together, this study implies that tangeretin might alleviate NAFLD through lowering oxidative stress in the liver by partial modulation of the Nrf2 pathway. Our study provided theoretical support that tangeretin could be used as a dietary therapy for obesity related-NAFLD or related metabolic syndrome.
C1 [Ke, Zunli; Li, Haiyang; Jiang, Shanshan; Li, Yuping; Chen, Rui] Guizhou Univ Tradit Chinese Med, Basic Med Sch, Guiyang 550025, Guizhou, Peoples R China.
   [Tan, Si] Yangtze Normal Univ, Sch Adv Agr & Bioengn, Chongqing 408100, Peoples R China.
   [Li, Mingxia] Third Mil Med Univ, Southwest Hosp, Dept Stem Cell & Regenerat Med, Army Med Univ, Chongqing 400038, Peoples R China.
C3 Guizhou University of Traditional Chinese Medicine; Yangtze Normal
   University; Army Medical University
RP Li, MX (corresponding author), Third Mil Med Univ, Southwest Hosp, Dept Stem Cell & Regenerat Med, Army Med Univ, Chongqing 400038, Peoples R China.
EM WYLHLMX@163.com
RI Jiang, Shanshan/O-8265-2019; Li, Haiyang/HJZ-3793-2023
FU National Natural Science Foundation of China [82060797]; Guizhou
   Academic Talents and Innovative Exploration Projects [[2018]5766-17];
   Guizhou Province Department of Education Youth Science and Technology
   Talent Growth Project [[2021] 195]; Science and Technology Foundation of
   Guizhou Province [Qian kehejichu-ZK [2021] yiban 400]; Doctoral Fund of
   Guizhou University of Traditional Chinese Medicine [[2019] 28]; Program
   of Innovative Scientific and Technological Talent Team of Guizhou
   Province [2020-5010]
FX This work was supported by the National Natural Science Foundation of
   China (Grant No. 82060797), the Guizhou Academic Talents and Innovative
   Exploration Projects (Qian kehe platform talents [2018]5766-17), the
   Guizhou Province Department of Education Youth Science and Technology
   Talent Growth Project (Guizhou Education KY word [2021] 195), the
   Science and Technology Foundation of Guizhou Province (No. Qian
   kehejichu-ZK [2021] yiban 400), the Doctoral Fund of Guizhou University
   of Traditional Chinese Medicine ([2019] 28) and the Program of
   Innovative Scientific and Technological Talent Team of Guizhou Province
   (2020-5010).
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NR 22
TC 15
Z9 16
U1 7
U2 59
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PD MAR 7
PY 2022
VL 13
IS 5
BP 2782
EP 2790
DI 10.1039/d1fo02989d
EA JAN 2022
PG 9
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA ZO1BY
UT WOS:000755897700001
PM 35171164
DA 2025-06-11
ER

PT J
AU Razani, B
   Chakravarthy, MV
   Semenkovich, CF
AF Razani, Babak
   Chakravarthy, Manu V.
   Semenkovich, Clay F.
TI Insulin Resistance and Atherosclerosis
SO ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA
LA English
DT Review
ID CORONARY-HEART-DISEASE; NF-KAPPA-B; OXIDATIVE DNA-DAMAGE; CARDIOVASCULAR
   RISK-FACTORS; JUN NH2-TERMINAL KINASE; NECROSIS-FACTOR-ALPHA; METABOLIC
   SYNDROME; MYOCARDIAL-INFARCTION; NITRIC-OXIDE; ENDOTHELIAL DYSFUNCTION
AB Insulin resistance characterizes type 2 diabetes and the metabolic syndrome, disorders associated with an increased risk of death due to macrovascular disease. In the past few decades, research from both the basic science and clinical arenas has enabled evidence-based use of therapeutic modalities such as statins and angiotensin-converting enzyme inhibitors to reduce cardiovascular (CV) mortality in insulin-resistant patients. Recently, promising drugs such as the thiazolidinediones have come under scrutiny for possible deleterious CV effects. Ongoing research has broadened our understanding of the pathophysiology of atherosclerosis, implicating detrimental effects of inflammation and the cellular stress response on the vasculature. In this review, we address current thinking that is shaping our molecular understanding of insulin resistance and atherosclerosis.
C1 [Chakravarthy, Manu V.; Semenkovich, Clay F.] Washington Univ, Sch Med, Dept Med, Div Endocrinol Metab & Lipid Res, St Louis, MO 63110 USA.
   [Razani, Babak] Washington Univ, Sch Med, Dept Med, Div Cardiovasc, St Louis, MO 63110 USA.
C3 Washington University (WUSTL); Washington University (WUSTL)
RP Semenkovich, CF (corresponding author), Washington Univ, Sch Med, Dept Med, Div Endocrinol Metab & Lipid Res, Campus Box 8127,660 S Enclid Ave, St Louis, MO 63110 USA.
EM csemenko@wustl.edu
RI Segura-Aguilar, Juan/H-8839-2013; Chakravarthy, Manu/AAD-7553-2021
OI Semenkovich, Clay/0000-0003-1163-1871; Razani, Babak/0000-0002-7172-9240
FU National Institutes of Health [HL083762, DK076729]
FX This work was supported by Grants HL083762 and DK076729 from the
   National Institutes of Health.
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NR 126
TC 95
Z9 104
U1 0
U2 4
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0889-8529
EI 1558-4410
J9 ENDOCRIN METAB CLIN
JI Endocrinol. Metabol. Clin. North Amer.
PD SEP
PY 2008
VL 37
IS 3
BP 603
EP +
DI 10.1016/j.ecl.2008.05.001
PG 20
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 357WJ
UT WOS:000259877600005
PM 18775354
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Le, MH
   Le, DM
   Baez, TC
   Dang, HS
   Nguyen, VH
   Lee, KS
   Stave, CD
   Ito, T
   Wu, YK
   Yeo, YH
   Ji, FP
   Cheung, R
   Nguyen, MH
AF Le, Michael H.
   Le, David M.
   Baez, Thomas C.
   Dang, Hansen
   Nguyen, Vy H.
   Lee, Keeseok
   Stave, Christopher D.
   Ito, Takanori
   Wu, Yuankai
   Yeo, Yee Hui
   Ji, Fanpu
   Cheung, Ramsey
   Nguyen, Mindie H.
TI Global incidence of adverse clinical events in nonalcoholic fatty liver
   disease: A systematic review and meta-analysis
SO CLINICAL AND MOLECULAR HEPATOLOGY
LA English
DT Article
DE NAFLD; Cirrhosis; Meta-analysis; Epidemiology
ID NAFLD; PREVALENCE; MORTALITY; OUTCOMES
AB Background/Aims: Nonalcoholic fatty liver disease (NAFLD) is associated with a multitude of adverse outcomes. We aimed to estimate the pooled incidence of NAFLD-related adverse events. Methods: We performed a systematic review and meta-analysis of cohort studies of adults with NAFLD to evaluate the pooled incidence of adverse events. Results: 19,406 articles were screened, 409 full-text articles reviewed, and 79 eligible studies (1,377,466 persons) were included. Mean age was 51.47 years and body mass index 28.90 kg/m( 2) . Baseline comorbidities included metabolic syndrome (41.73%), cardiovascular disease (CVD) (16.83%), cirrhosis (21.97%), and nonalcoholic steatohepatitis (NASH) (58.85%). Incidence rate per 1,000 person-years for mortality included: all-cause (14.6), CVD-related (4.53), non-liver cancer-related (4.53), and liver-related (3.10). Incidence for liver-related events included overall (24.3), fibrosis progression (49.0), cirrhosis (10.9), liver transplant (12.0), and hepatocellular carcinoma (HCC) (3.39). Incidence for non-liver events included metabolic syndrome (25.4), hypertension (25.8), dyslipidemia (26.4), diabetes (19.0), CVD (24.77), renal impairment (30.3), depression/anxiety (29.1), and non-liver cancer (10.5). Biopsy-proven NASH had higher incidence of HCC ( P =0.043) compared to non-NASH. Higher rates of CVD and mortality were observed in North America and Europe, hypertension and non-liver cancer in North America, and HCC in Western Pacific/Southeast Asia ( P <0.05). No significant differences were observed by sex. Time -period analyses showed decreasing rates of cardiovascular and non-liver cancer mortality and increasing rates of decompensated cirrhosis ( P <0.05). Conclusions: People with NAFLD have high incidence of liver and non-liver adverse clinical events, varying by NASH, geographic region, and time-period, but not sex.
C1 [Le, Michael H.] Univ Vermont, Larner Coll Med, Burlington, VT USA.
   [Le, Michael H.; Le, David M.; Dang, Hansen; Nguyen, Vy H.; Cheung, Ramsey; Nguyen, Mindie H.] Stanford Univ, Div Gastroenterol & Hepatol, Med Ctr, 780 Welch Rd, Palo Alto, CA 94304 USA.
   [Le, David M.; Baez, Thomas C.] Burrell Coll Osteopath Med, Las Cruces, NM USA.
   [Dang, Hansen] Univ Iowa, Carver Coll Med, Iowa City, IA USA.
   [Nguyen, Vy H.] Harvard Med Sch, Boston, MA USA.
   [Lee, Keeseok] Stanford Univ, Stanford, CA USA.
   [Stave, Christopher D.] Stanford Univ, Lane Lib, Sch Med, Stanford, CA USA.
   [Ito, Takanori] Nagoya Univ, Dept Gastroenterol & Hepatol, Grad Sch Med, Nagoya, Japan.
   [Wu, Yuankai] Sun Yat Sen Univ, Affiliated Hosp 3, Dept Infect Dis, Guangzhou, Peoples R China.
   [Yeo, Yee Hui] Cedars Sinai Med Ctr, Karsh Div Gastroenterol & Hepatol, Los Angeles, CA USA.
   [Ji, Fanpu] Xi An Jiao Tong Univ, Affiliated Hosp 2, Dept Infect Dis, Xian, Shaanxi, Peoples R China.
   [Ji, Fanpu] Xi An Jiao Tong Univ, Natl & Local Joint Engn Res Ctr Biodiag & Biothera, Affiliated Hosp 2, Xian, Shaanxi, Peoples R China.
   [Cheung, Ramsey] Palo Alto Vet Affairs Med Ctr, Div Gastroenterol & Hepatol, Palo Alto, CA USA.
   [Nguyen, Mindie H.] Stanford Univ, Dept Epidemiol & Populat Hlth, Med Ctr, Palo Alto, CA USA.
C3 University of Vermont; Stanford University; University of Iowa; Harvard
   University; Harvard Medical School; Stanford University; Stanford
   University; Nagoya University; Sun Yat Sen University; Cedars Sinai
   Medical Center; Xi'an Jiaotong University; Xi'an Jiaotong University;
   Stanford University
RP Nguyen, MH (corresponding author), Stanford Univ, Div Gastroenterol & Hepatol, Med Ctr, 780 Welch Rd, Palo Alto, CA 94304 USA.
EM mindiehn@stanford.edu
RI Wu, Yuankai/Z-3147-2019; Yeo, Y/GWV-3316-2022; Nguyen,
   Huong/AAI-6249-2020; Huy, Nguyen Tien/B-2573-2010
OI Le, Michael/0000-0001-5051-3160; Nguyen, Vy/0000-0002-9888-8321
FX Conflicts of Interest MHN: Research funding: Pfizer, Enanta, Astra
   Zeneca, Delfi Technologies, GSK, Gilead, CurveBio, Exact Sciences, Helio
   Health, Glycotest, Vir Biotech; Consulting: Exelixis, Gilead,
   In-tercept, GSK, Exact Science.
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NR 36
TC 27
Z9 28
U1 20
U2 26
PU KOREAN ASSOC STUDY LIVER
PI SEOUL
PA RM A1210, 53 MAPO-DAERO, MAPOTRAPALACE, DOWHA-DONG, MAPO-GU, SEOUL,
   04158, SOUTH KOREA
SN 2287-2728
EI 2287-285X
J9 CLIN MOL HEPATOL
JI Clin. Mol. Hepatol.
PD APR
PY 2024
VL 30
IS 2
DI 10.3350/cmh.2023.0485
PG 13
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA WP6P0
UT WOS:001256119500003
PM 38281814
OA Green Published, gold
HC Y
HP N
DA 2025-06-11
ER

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   Hota, Susy S.
   Comelli, Elena M.
   Philpott, Dana
   Jackson, Timothy D.
   Okrainec, Allan
   Gaisano, Herbert Y.
   Allard, Johane P.
TI Effect of faecal microbial transplant via colonoscopy in patients with
   severe obesity and insulin resistance: A randomized double-blind,
   placebo-controlled Phase 2 trial
SO DIABETES OBESITY & METABOLISM
LA English
DT Article
DE colonoscopy; faecal microbiota transplant; insulin resistance;
   intestinal microbiome; metabolic syndrome; obesity
ID METABOLIC SYNDROME; INTESTINAL MICROBIOTA; KYNURENINE PATHWAY;
   SENSITIVITY; MODEL
AB Aim To assess the effects of faecal microbial transplant (FMT) from lean people to subjects with obesity via colonoscopy. Material and Methods In a double-blind, randomized controlled trial, subjects with a body mass index >= 35 kg/m(2) and insulin resistance were randomized, in a 1:1 ratio in blocks of four, to either allogenic (from healthy lean donor; n = 15) or autologous FMT (their own stool; n = 13) delivered in the caecum and were followed for 3 months. The main outcome was homeostatic model assessment of insulin resistance (HOMA-IR) and secondary outcomes were glycated haemoglobin levels, lipid profile, weight, gut hormones, endotoxin, appetite measures, intestinal microbiome (IM), metagenome, serum/faecal metabolites, quality of life, anxiety and depression scores. Results In the allogenic versus autologous groups, HOMA-IR and clinical variables did not change significantly, but IM and metabolites changed favourably (P < 0.05): at 1 month, Coprococcus, Bifidobacterium, Bacteroides and Roseburia increased, and Streptococcus decreased; at 3 months, Bacteroides and Blautia increased. Several species also changed significantly. For metabolites, at 1 month, serum kynurenine decreased and faecal indole acetic acid and butenylcarnitine increased, while at 3 months, serum isoleucine, leucine, decenoylcarnitine and faecal phenylacetic acid decreased. Metagenomic pathway representations and network analyses assessing relationships with clinical variables, metabolites and IM were significantly enhanced in the allogenic versus autologous groups. LDL and appetite measures improved in the allogenic (P < 0.05) but not in the autologous group. Conclusions Overall, in those with obeisty, allogenic FMT via colonoscopy induced favourable changes in IM, metabolites, pathway representations and networks even though other metabolic variables did not change. LDL and appetite variables may also benefit.
C1 [Ghorbani, Yasaman] Univ Toronto, Inst Med Sci, Toronto, ON, Canada.
   [Ghorbani, Yasaman; Schwenger, Katherine J. P.; Sharma, Divya; Allard, Johane P.] Univ Hlth Network, Toronto Gen Hosp, Toronto, ON, Canada.
   [Jung, Hyejung; Lou, Wendy] Univ Toronto, Dalla Lana Publ Hlth Dept, Toronto, ON, Canada.
   [Yadav, Jitender; Philpott, Dana] Univ Toronto, Dept Immunol, Toronto, ON, Canada.
   [Xu, Wei] Univ Hlth Network, Princess Margaret Canc Ctr, Toronto, ON, Canada.
   [Poutanen, Susan] Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON, Canada.
   [Poutanen, Susan] Sinai Hlth Syst, Dept Microbiol, Toronto, ON, Canada.
   [Poutanen, Susan; Hota, Susy S.; Gaisano, Herbert Y.; Allard, Johane P.] Univ Toronto, Dept Med, Toronto, ON, Canada.
   [Hota, Susy S.] Univ Hlth Network, Dept Med, Toronto, ON, Canada.
   [Hota, Susy S.] Univ Hlth Network, Infect Prevent & Control Dept, Toronto, ON, Canada.
   [Comelli, Elena M.; Allard, Johane P.] Univ Toronto, Dept Nutr Sci, Toronto, ON, Canada.
   [Jackson, Timothy D.; Okrainec, Allan] Univ Toronto, Div Gen Surg, Toronto, ON, Canada.
   [Jackson, Timothy D.; Okrainec, Allan] Univ Hlth Network, Toronto Western Hosp, Div Gen Surg, Toronto, ON, Canada.
C3 University of Toronto; University of Toronto; University Health Network
   Toronto; Toronto General Hospital; University of Toronto; University of
   Toronto; University of Toronto; University Health Network Toronto;
   Princess Margaret Cancer Centre; University of Toronto; University of
   Toronto; Sinai Health System Toronto; Lunenfeld Tanenbaum Research
   Institute; University of Toronto; University of Toronto; University
   Health Network Toronto; University of Toronto; University Health Network
   Toronto; University of Toronto; University of Toronto; University of
   Toronto; University Health Network Toronto
RP Allard, JP (corresponding author), Toronto Gen Hosp, Dept Med, Div Gastroenterol, 585 Univ Ave,9 N-973, Toronto, ON M5G 2N2, Canada.
EM dr.johane.allard@uhn.ca
RI Hota, Susy/L-1903-2019; Okrainec, Allan/AAD-2260-2021; SHARMA,
   DIVYA/JNS-2500-2023; Poutanen, Susan/N-8066-2019
FU Banting and Best Diabetes Centre, University of Toronto; Charles
   Hollenberg Summer Studentship; Canadian Institutes of Health Research
   [TB2-138775]
FX Banting and Best Diabetes Centre, University of Toronto and the Charles
   Hollenberg Summer Studentship; Canadian Institutes of Health Research,
   Grant/Award Number: TB2-138775
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NR 59
TC 8
Z9 9
U1 2
U2 15
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1462-8902
EI 1463-1326
J9 DIABETES OBES METAB
JI Diabetes Obes. Metab.
PD FEB
PY 2023
VL 25
IS 2
BP 479
EP 490
DI 10.1111/dom.14891
EA OCT 2022
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 8R8WZ
UT WOS:000874477200001
PM 36239189
DA 2025-06-11
ER

PT J
AU Ng, AE
   Kubzansky, LD
   Guimond, AJ
   Trudel-Fitzgerald, C
AF Ng, Amanda E.
   Kubzansky, Laura D.
   Guimond, Anne-Josee
   Trudel-Fitzgerald, Claudia
TI Are There Sociodemographic-Specific Associations of Coping With Heart
   Disease and Diabetes Incidence?
SO HEALTH PSYCHOLOGY
LA English
DT Article
DE coping; coping variability; cardiometabolic risk; diabetes; heart
   disease
ID CARDIOVASCULAR-DISEASE; HEALTH BEHAVIORS; RISK-FACTORS; LIFE;
   HYPERTENSION; STRATEGIES; ANXIETY; STRESS; FLEXIBILITY; DEPRESSION
AB Objective: Psychological factors, including psychological distress and well-being, have been associated with cardiometabolic disease risk. Here, we examined whether a psychological process, namely how individuals cope with stressors, relates to such risk, which has been understudied. Method: During 2004-2006, 2,142 participants without heart disease and diabetes from the Midlife in the U.S. study completed a validated coping inventory assessing six strategies (positive reinterpretation and growth, active coping, planning, focus on and venting of emotion, denial, and behavioral disengagement) and relevant covariates. As a proxy for coping flexibility, participants were also classified as having lower, moderate, or greater variability in their use of these strategies. Heart disease and diabetes were documented in 2013-2015. Logistic regressions modeled adjusted odds ratios (AORs) and 95% confidence intervals (CIs) of developing heart disease and diabetes, separately, with coping exposures. Results: In sociodemographic-adjusted models, greater use of adaptive strategies predicted lower diabetes risk (e.g., positive reinterpretation and growth: AOR = 0.83; 95% CI [0.72, 0.96]); estimates were weaker for maladaptive strategies, and all strategies were unrelated to heart disease. All associations for coping variability were null. In secondary analyses, greater use of adaptive strategies predicted lower heart disease risk in more educated participants only (e.g., active coping: AOR = 0.71; 95% CI [0.55, 0.92]) and lower diabetes risk in females only (e.g., planning: AOR = 0.75; 95% CI [0.61, 0.91]). Results were maintained additionally adjusting for health, behavioral, and social factors. Conclusions: Findings suggest sex and education differences in coping's association with heart disease and diabetes. Future studies should recognize adaptive strategies may be more potent for health among certain populations. Public Significance Statement Despite convincing evidence linking stressors and psychological distress to cardiometabolic disease risk, this is the first study examining the role of stress-related coping strategies and variability in their use in the onset of heart disease and diabetes. Results suggest the associations of coping with these conditions vary by sex and education levels, which underscores the importance of evaluating psychosocial interventions that are sociodemographic-specific to possibly prevent heart disease and diabetes.
C1 [Ng, Amanda E.] Univ Maryland, Sch Publ Hlth, Dept Epidemiol, College Pk, MD USA.
   [Kubzansky, Laura D.; Guimond, Anne-Josee] Harvard TH Chan Sch Publ Hlth, Dept Social & Behav Sci, Boston, MA 02115 USA.
   [Guimond, Anne-Josee; Trudel-Fitzgerald, Claudia] Harvard TH Chan Sch Publ Hlth, Lee Kum Sheung Ctr Hlth & Happiness, Boston, MA USA.
   [Trudel-Fitzgerald, Claudia] Univ Quebec Trois Rivieres, Dept Psychol, 3600 Rue St Marguer, Trois Rivieres, PQ G9A5H7, Canada.
   [Trudel-Fitzgerald, Claudia] Inst Univ Sante Mentale Montreal, Montreal, PQ, Canada.
C3 University System of Maryland; University of Maryland College Park;
   Harvard University; Harvard T.H. Chan School of Public Health; Harvard
   University; Harvard T.H. Chan School of Public Health; University of
   Quebec; University of Quebec Trois Rivieres; Universite de Montreal
RP Trudel-Fitzgerald, C (corresponding author), Univ Quebec Trois Rivieres, Dept Psychol, 3600 Rue St Marguer, Trois Rivieres, PQ G9A5H7, Canada.
EM claudia.trudel-fitzgerald@uqtr.ca
RI Guimond, Anne-JosÃ©e/ABG-8892-2020
OI Trudel-Fitzgerald, Claudia/0000-0001-9989-4259; Ng,
   Amanda/0000-0002-5212-3147
FU John D. and Catherine T. MacArthur Foundation Research Network; National
   Institute on Aging [P01-AG020166, U19-AG051426]; Canadian Institutes of
   Health Research; Lee Kum Sheung Center for Health and Happiness at the
   Harvard T.H. Chan School of Public Health; National Institutes of Health
   [R25-AT0106641]
FX The Midlife in the United States (MIDUS) study has been funded by the
   John D. and Catherine T. MacArthur Foundation Research Network and the
   National Institute on Aging (P01-AG020166; U19-AG051426). Claudia
   Trudel-Fitzgerald is the Research Chair on Social Disparities, Coping,
   and Health at Universite du Quebec a Trois-Rivieres. Anne-Josee Guimond
   received a postdoctoral fellowship from the Canadian Institutes of
   Health Research. Claudia Trudel-Fitzgerald, Amanda E. Ng, and Anne-Josee
   Guimond received salary support from the Lee Kum Sheung Center for
   Health and Happiness at the Harvard T.H. Chan School of Public Health.
   This study was also informed by the Michigan Integrative Well-Being and
   Inequality Training Program, which is funded by a grant from the
   National Institutes of Health (R25-AT0106641)
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NR 48
TC 3
Z9 3
U1 0
U2 5
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 0278-6133
EI 1930-7810
J9 HEALTH PSYCHOL
JI Health Psychol.
PD OCT
PY 2024
VL 43
IS 10
BP 757
EP 767
DI 10.1037/hea0001386
EA JUN 2024
PG 11
WC Psychology, Clinical; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology
GA I1H8P
UT WOS:001300852500001
PM 38884978
DA 2025-06-11
ER

PT J
AU Machado, MV
   Michelotti, GA
   Jewell, ML
   Pereira, TA
   Xie, G
   Premont, RT
   Diehl, AM
AF Machado, M. V.
   Michelotti, G. A.
   Jewell, M. L.
   Pereira, T. A.
   Xie, G.
   Premont, R. T.
   Diehl, A. M.
TI Caspase-2 promotes obesity, the metabolic syndrome and nonalcoholic
   fatty liver disease
SO CELL DEATH & DISEASE
LA English
DT Article
ID WHITE ADIPOSE-TISSUE; GENE-EXPRESSION; CELL-SIZE; CASPASE-2-DEFICIENT
   MICE; INSULIN-RESISTANCE; HEPATIC STEATOSIS; OXIDATIVE STRESS; ADIPOCYTE
   DEATH; APOPTOSIS; REGULATOR
AB Obesity and its resulting metabolic disturbances are major health threats. In response to energy surplus, overtaxed adipocytes release fatty acids and pro-inflammatory factors into the circulation, promoting organ fat accumulation (including nonalcoholic fatty liver disease), insulin resistance and the metabolic syndrome. Recently, caspase-2 was linked to lipoapoptosis, so we hypothesized that caspase-2 might be a critical determinant of metabolic syndrome pathogenesis. Caspase-2-deficient and wildtype mice were fed a Western diet (high-fat diet, enriched with saturated fatty acids and 0.2% cholesterol, supplemented with fructose and glucose in the drinking water) for 16 weeks. Metabolic and hepatic outcomes were evaluated. In vitro studies assessed the role of caspase-2 in adipose tissue proliferative properties and susceptibility for lipoapoptosis. Caspase-2-deficient mice fed a Western diet were protected from abdominal fat deposition, diabetes mellitus, dyslipidemia and hepatic steatosis. Adipose tissue in caspase-2-deficient mice was more proliferative, upregulated mitochondrial uncoupling proteins consistent with browning, and was resistant to cell hypertrophy and cell death. The liver was protected from steatohepatitis through a decrease in circulating fatty acids and more efficient hepatic fat metabolism, and from fibrosis as a consequence of reduced fibrogenic stimuli from fewer lipotoxic hepatocytes. Caspase-2 deficiency protected mice from diet-induced obesity, metabolic syndrome and nonalcoholic fatty liver disease. Further studies are necessary to assess caspase-2 as a therapeutic target for those conditions.
C1 [Machado, M. V.; Michelotti, G. A.; Jewell, M. L.; Pereira, T. A.; Xie, G.; Premont, R. T.; Diehl, A. M.] Duke Univ, Med Ctr, Dept Med, Div Gastroenterol, 905S LaSalle St,Snyderman Bldg,Suite 1073, Durham, NC 27710 USA.
   [Machado, M. V.] Hosp Santa Maria, Dept Gastroenterol, Lisbon, Portugal.
C3 Duke University; Universidade de Lisboa; Hospital Santa Maria
RP Diehl, AM (corresponding author), Duke Univ, Med Ctr, Dept Med, Div Gastroenterol, 905S LaSalle St,Snyderman Bldg,Suite 1073, Durham, NC 27710 USA.
EM diehl004@mc.duke.edu
RI de Almeida Pereira, Thiago/E-3092-2013
OI de Almeida Pereira, Thiago/0000-0002-8755-0683; Premont, Richard
   T./0000-0002-8053-5026; , Gregory/0000-0002-3936-4675
FU NIH [DK0077794, DK053792, R37 AA010154]; Duke Endowment: The Florence
   McAlister Professorship; FCT, Portugal
FX We thank Sally Kornbluth, Ph.D., for helpful discussions, and Farshid
   Guilak, Ph.D., for helping us to perform DXA experiments. This research
   is supported by NIH DK0077794, DK053792 and R37 AA010154 (Diehl AM), and
   Duke Endowment: The Florence McAlister Professorship (Diehl AM). MVM is
   a receiver of a Ph.D. grant from FCT, Portugal.
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NR 61
TC 40
Z9 46
U1 0
U2 9
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 2041-4889
J9 CELL DEATH DIS
JI Cell Death Dis.
PD FEB
PY 2016
VL 7
AR e2096
DI 10.1038/cddis.2016.19
PG 12
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA DR3GS
UT WOS:000379791300008
PM 26890135
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Sandoval-Bórquez, A
   Carrión, P
   Hernández, MP
   Pérez, JA
   Tapia-Castillo, A
   Vecchiola, A
   Fardella, CE
   Carvajal, CA
AF Sandoval-Borquez, Alejandra
   Carrion, Pablo
   Hernandez, Maria Paz
   Perez, Jorge A.
   Tapia-Castillo, Alejandra
   Vecchiola, Andrea
   Fardella, Carlos E.
   Carvajal, Cristian A.
TI Adipose Tissue Dysfunction and the Role of Adipocyte-Derived
   Extracellular Vesicles in Obesity and Metabolic Syndrome
SO JOURNAL OF THE ENDOCRINE SOCIETY
LA English
DT Review
DE obesity; metabolic syndrome; adipocyte-derived extracellular vesicles
   (AdEVs)
ID EXOSOMAL MIRNAS; CELL; INFLAMMATION; BIOGENESIS; SECRETION; MECHANISM;
   PROTEINS
AB Obesity is a major public health issue that is associated with metabolic diseases including diabetes mellitus type 2 and metabolic syndrome. This pathology leads to detrimental cardiovascular health and secondary effects, such as lipotoxicity, inflammation, and oxidative stress. Recently, extracellular vesicles (EVs) have been highlighted as novel players participating in human physiology and pathophysiology. In obesity, adipose tissue is related to the active shedding of adipocyte-derived extracellular vesicles (AdEVs). The current review explores and highlights the role of AdEVs and their cargo in obesity and metabolic syndrome. AdEVs are proposed to play an important role in obesity and its comorbidities. AdEVs are biological nanoparticles mainly shed by visceral and subcutaneous adipose tissue, acting in physiological and pathophysiological conditions, and also carrying different cargo biomolecules, such as RNA, microRNA (miRNA), proteins, and lipids, among others. RNA and miRNA have local and systemic effects affecting gene expression in target cell types via paracrine and endocrine actions. State of the art analyses identified some miRNAs, such as miR-222, miR-23b, miR-4429, miR-148b, and miR-4269, that could potentially affect cell pathways involved in obesity-related comorbidities, such as chronic inflammation and fibrosis. Similarly, AdEVs-proteins (RBP4, perilipin-A, FABP, mimecan, TGFBI) and AdEVs-lipids (sphingolipids) have been linked to the obesity pathophysiology. The current knowledge about AdEVs along with further research would support and reveal novel pathways, potential biomarkers, and therapeutic options in obesity.
C1 [Sandoval-Borquez, Alejandra] Pontificia Univ Catolica Valparaiso, Fac Sci, Sch Med Technol, Valparaiso 2373223, Chile.
   [Carrion, Pablo; Hernandez, Maria Paz; Perez, Jorge A.; Tapia-Castillo, Alejandra; Vecchiola, Andrea; Fardella, Carlos E.; Carvajal, Cristian A.] Pontificia Univ Catolica Chile, Ctr Translat Res Endocrinol CETREN UC, Santiago 8330074, Chile.
   [Carrion, Pablo; Hernandez, Maria Paz; Perez, Jorge A.; Tapia-Castillo, Alejandra; Vecchiola, Andrea; Fardella, Carlos E.; Carvajal, Cristian A.] Pontificia Univ Catolica Chile, Sch Med, Dept Endocrinol, Santiago 8330077, Chile.
C3 Pontificia Universidad Catolica de Valparaiso; Pontificia Universidad
   Catolica de Chile; Pontificia Universidad Catolica de Chile
RP Fardella, CE; Carvajal, CA (corresponding author), Pontificia Univ Catolica Chile, Escuela Med, Dept Endocrinol, Diagonal Paraguay 362,Piso 4, Santiago 8330077, Chile.
EM cfardella@med.puc.cl; ccarvajm@uc.cl
RI Sandoval, Alejandra/HKV-3194-2023; Carvajal, Cristian/HLH-7846-2023
OI TAPIA-CASTILLO, ALEJANDRA/0000-0002-6081-1468; Sandoval-Borquez,
   Alejandra/0000-0002-1632-6449; Perez, Jorge A./0000-0003-4745-6219;
   Carrion Valdes, Pablo Alejandro/0009-0009-4431-219X; Hernandez Mejias,
   Maria Paz/0009-0002-0877-8055
FU ANID- CONICYT FONDECYT [1212006]; FONDECYT POSTDOCTORAL [3200646, SOCHED
   2023-09]; CETREN-UC
FX This work was supported by the following grants: ANID- CONICYT FONDECYT
   1212006; FONDECYT POSTDOCTORAL 3200646, SOCHED 2023-09, and CETREN-UC.
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NR 69
TC 1
Z9 1
U1 3
U2 3
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
EI 2472-1972
J9 J ENDOCR SOC
JI J. Endocr. Soc.
PD JUL 10
PY 2024
VL 8
IS 8
AR bvae126
DI 10.1210/jendso/bvae126
PG 8
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA YH1G4
UT WOS:001267499700002
PM 38988671
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Feraco, A
   Marzolla, V
   Scuteri, A
   Armani, A
   Caprio, M
AF Feraco, Alessandra
   Marzolla, Vincenzo
   Scuteri, Angelo
   Armani, Andrea
   Caprio, Massimiliano
TI Mineralocorticoid Receptors in Metabolic Syndrome: From Physiology to
   Disease
SO TRENDS IN ENDOCRINOLOGY AND METABOLISM
LA English
DT Review
ID BROWN ADIPOSE-TISSUE; PROSTAGLANDIN D SYNTHASE; ENDOTHELIAL FUNCTION;
   ARTERIAL STIFFNESS; OXIDATIVE STRESS; GLUCOCORTICOID-RECEPTOR; ADIPOCYTE
   DYSFUNCTION; PRIMARY ALDOSTERONISM; VASCULAR DYSFUNCTION;
   GENE-TRANSCRIPTION
AB Over the past decade, several studies have shown that activity of extra-renal mineralocorticoid receptors (MR) regulates vascular tone, adipogenesis, adipose tissue function, and cardiomyocyte contraction. In mice, abnormal activation of MR in the vasculature and in adipose tissue favors the occurrence of several components of the metabolic syndrome (MetS), such as hypertension, obesity, and glucose intolerance. Accordingly, high levels of aldosterone are associated with obesity and MetS in humans, suggesting that altered activation of aldosterone-MR system in extra-renal tissues leads to profound metabolic dysfunctions. In this context, in addition to the classical indications for heart failure and hypertension, MR antagonists (MRAs) nowadays represent a promising approach to tackle cardiovascular and metabolic disorders occurring in the MetS.
C1 [Feraco, Alessandra; Marzolla, Vincenzo; Armani, Andrea; Caprio, Massimiliano] IRCCS San Raffaele Pisana, Lab Cardiovasc Endocrinol, Rome, Italy.
   [Scuteri, Angelo] Univ Sassari, Dept Med Surg & Expt Sci, Sassari, Italy.
   [Caprio, Massimiliano] San Raffaele Roma Open Univ, Dept Human Sci & Promot Qual Life, Rome, Italy.
C3 IRCCS San Raffaele Pisana; University of Sassari
RP Caprio, M (corresponding author), IRCCS San Raffaele Pisana, Lab Cardiovasc Endocrinol, Rome, Italy.; Caprio, M (corresponding author), San Raffaele Roma Open Univ, Dept Human Sci & Promot Qual Life, Rome, Italy.
EM massimiliano.caprio@sanraffaele.it
RI Armani, Andrea/AAC-2071-2022; Feraco, Alessandra/K-5920-2016; Caprio,
   Massimiliano/J-3020-2012; Marzolla, Vincenzo/K-7769-2016
OI Feraco, Alessandra/0000-0002-7074-0480; SCUTERI,
   ANGELO/0000-0003-4784-5441; Caprio, Massimiliano/0000-0003-0722-7163;
   Marzolla, Vincenzo/0000-0002-2943-7631
FU Italian Ministry of Health [GR-2013-02357959]; MIUR [2015ZTT5KB]; Bayer
   AG
FX This work was supported by funding from the Italian Ministry of Health
   (Ricerca Corrente; Bando Giovani Ricercatori 2013 project grant
   GR-2013-02357959 to A.F., Principal Investigator) and by a grant of MIUR
   (Progetti di Ricerca di Interesse Nazionale 2015, project code
   2015ZTT5KB, to M.C., Work Package Leader). M.C. received research grants
   from Bayer AG. The other authors declare no conflicts of interest.
   Figure generation has been performed using BioRender.
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NR 104
TC 54
Z9 54
U1 0
U2 5
PU CELL PRESS
PI CAMBRIDGE
PA 50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA
SN 1043-2760
EI 1879-3061
J9 TRENDS ENDOCRIN MET
JI Trends Endocrinol. Metab.
PD MAR
PY 2020
VL 31
IS 3
BP 205
EP 217
DI 10.1016/j.tem.2019.11.006
PG 13
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA KN4PR
UT WOS:000514821100003
PM 31843490
DA 2025-06-11
ER

PT S
AU Mahdavi, A
   Bagherniya, M
   Mirenayat, MS
   Atkin, SL
   Sahebkar, A
AF Mahdavi, Atena
   Bagherniya, Mohammad
   Mirenayat, Mohammad Sadegh
   Atkin, Stephen L.
   Sahebkar, Amirhossein
BE Barreto, GE
   Sahebkar, A
TI Medicinal Plants and Phytochemicals Regulating Insulin Resistance and
   Glucose Homeostasis in Type 2 Diabetic Patients: A Clinical Review
SO PHARMACOLOGICAL PROPERTIES OF PLANT-DERIVED NATURAL PRODUCTS AND
   IMPLICATIONS FOR HUMAN HEALTH
SE Advances in Experimental Medicine and Biology
LA English
DT Review; Book Chapter
DE Type 2 diabetes; Metabolic syndrome; Insulin resistance; Medicinal
   plants
ID CARDIOVASCULAR RISK-FACTORS; IMPROVES GLYCEMIC CONTROL; RANDOMIZED
   DOUBLE-BLIND; FASTING PLASMA-INSULIN; GREEN TEA CONSUMPTION; FATTY
   LIVER-DISEASE; OXIDATIVE STRESS; HEALTH-BENEFITS; RESVERATROL
   SUPPLEMENTATION; METABOLIC SYNDROME
AB Diabetes is a major health problem affecting more than four hundred million adults worldwide. The transition from normal glucose tolerance to type 2 diabetes (T2D) is preceded by increased Insulin resistance (IR), an independent predictor of the development of T2D in high risk (e.g. obese populations, pre-diabetes) individuals. Insulin deficiency resulting from increased IR results in progressive glucose homeostasis dysfunction. Data has shown that IR is affected by many different factors such as genetics, age, exercise, dietary nutrients, obesity, and body fat distribution. One of the most important factors is diet, which plays an essential role in addressing T2D and metabolic syndrome. Nutraceuticals and medicinal plants have been shown to have efficacy in preventing chronic diseases like cancer, non-alcoholic fatty liver disease (NAFLD), cardiovascular disease, diabetes mellitus and metabolic syndrome, likely through the anti-inflammatory properties found in nutraceuticals. However, the effect of these compounds, including traditional plant medicines, herbal formulations or their extracts on IR have not been systematically investigated. The objective of this review was to assess the reported effects of medicinal plants and bioactive natural compounds on IR. The findings confirm that most of the herbal bioactive compounds including resveratrol, garlic, curcumin, cinnamon, ginger, nuts, berberine, anthocyanin, soybean, flaxseed, vegetable oils, and soluble fibers have benefit in their efficacy for decreasing IR, fasting blood sugar (FBS), fasting insulin and HbA1c.
C1 [Mahdavi, Atena; Bagherniya, Mohammad] Isfahan Univ Med Sci, Food Secur Res Ctr, Sch Nutr & Food Sci, Dept Community Nutr, Esfahan, Iran.
   [Mirenayat, Mohammad Sadegh] Isfahan Univ Med Sci, Sch Nutr & Food Sci, Dept Community Nutr, Students Res Comm, Esfahan, Iran.
   [Atkin, Stephen L.] Weill Cornell Med Qatar, Doha, Qatar.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Appl Biomed Res Ctr, Mashhad, Razavi Khorasan, Iran.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Biotechnol Res Ctr, Mashhad, Razavi Khorasan, Iran.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Sch Pharm, Mashhad, Razavi Khorasan, Iran.
   [Sahebkar, Amirhossein] Polish Mothers Mem Hosp Res Inst PMMHRI, Lodz, Poland.
C3 Isfahan University of Medical Sciences; Isfahan University of Medical
   Sciences; Qatar Foundation (QF); Weill Cornell Medical College Qatar;
   Mashhad University of Medical Sciences; Mashhad University of Medical
   Sciences; Mashhad University of Medical Sciences
RP Sahebkar, A (corresponding author), Mashhad Univ Med Sci, Appl Biomed Res Ctr, Mashhad, Razavi Khorasan, Iran.; Sahebkar, A (corresponding author), Mashhad Univ Med Sci, Pharmaceut Technol Inst, Biotechnol Res Ctr, Mashhad, Razavi Khorasan, Iran.; Sahebkar, A (corresponding author), Mashhad Univ Med Sci, Sch Pharm, Mashhad, Razavi Khorasan, Iran.; Sahebkar, A (corresponding author), Polish Mothers Mem Hosp Res Inst PMMHRI, Lodz, Poland.
EM sahebkara@mums.ac.ir
RI Sahebkar, Amirhossein/B-5124-2018; Atkin, stephen/ABE-7047-2020
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NR 160
TC 28
Z9 31
U1 4
U2 42
PU SPRINGER INTERNATIONAL PUBLISHING AG
PI CHAM
PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND
SN 0065-2598
EI 2214-8019
BN 978-3-030-64872-5; 978-3-030-64871-8
J9 ADV EXP MED BIOL
JI Adv.Exp.Med.Biol.
PY 2021
VL 1308
BP 161
EP 183
DI 10.1007/978-3-030-64872-5_13
D2 10.1007/978-3-030-64872-5
PG 23
WC Chemistry, Medicinal; Medicine, Research & Experimental; Pharmacology &
   Pharmacy
WE Book Citation Index – Science (BKCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Research & Experimental Medicine
GA BR3MG
UT WOS:000647701200013
PM 33861444
DA 2025-06-11
ER

PT J
AU Fraulob, JC
   Ogg-Diamantino, R
   Fernandes-Santos, C
   Aguila, MB
   Mandarim-de-Lacerda, CA
AF Fraulob, Julio C.
   Ogg-Diamantino, Rebeca
   Fernandes-Santos, Caroline
   Aguila, Marcia Barbosa
   Mandarim-de-Lacerda, Carlos A.
TI A Mouse Model of Metabolic Syndrome: Insulin Resistance, Fatty Liver and
   Non-Alcoholic Fatty Pancreas Disease (NAFPD) in C57BL/6 Mice Fed a High
   Fat Diet
SO JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION
LA English
DT Article
DE metabolic syndrome; insulin resistance; fatty liver; non-alcoholic fatty
   pancreatic disease; high-fat diet
ID BETA-CELL; ADIPOSE-TISSUE; GLUCOSE-HOMEOSTASIS; DIABETES-MELLITUS;
   GLUCAGON; OBESITY; ADIPONECTIN; CHOLESTEROL; ASSOCIATION; STRESS
AB Diet-induced obesity in C57BL/6 mice triggers common features of human metabolic syndrome (MetS). The purpose is to assess the suitability of a diet-induced obesity model for investigating non-alcoholic fatty pancreatic disease (NAFPD), fatty liver and insulin resistance. Adult C57BL/6 mice were fed either high-fat chow (HFC, 60% fat) or standard chow (SC, 10% fat) during a 16-week period. We evaluated in both groups: hepatopancreatic injuries, pancreatic islets size, alpha and beta-cell immunodensities, intraperitoneal insulin tolerance test (IPITT) and oral glucose tolerance test (OGTT). The HFC mice displayed greater mass gain (p<0.0001) and total visceral fat pads (p<0.001). OGTT showed impairment of glucose clearance in HFC mice (p<0.0001). IPITT revealed insulin resistance in HFC mice (p<0.0001). The HFC mice showed larger pancreatic islet size and significantly greater alpha and beta-cell immunodensities than SC mice. Pancreas and liver from HFC were heavier and contained higher fat concentration. In conclusion, C57BL/6 mice fed a high-fat diet develop features of NAFPD. Insulin resistance and ectopic accumulation of hepatic fat are well known to occur in MetS. Additionally, the importance of fat accumulation in the pancreas has been recently highlighted. Therefore, this model could help to elucidate target organ alterations associated with metabolic syndrome.
C1 [Fraulob, Julio C.; Ogg-Diamantino, Rebeca; Fernandes-Santos, Caroline; Aguila, Marcia Barbosa; Mandarim-de-Lacerda, Carlos A.] Univ Estado Rio De Janeiro, Lab Morphometry & Cardiovasc Morphol, Biomed Ctr, Inst Biol, BR-20551030 Rio De Janeiro, Brazil.
C3 Universidade do Estado do Rio de Janeiro
RP Mandarim-de-Lacerda, CA (corresponding author), Univ Estado Rio De Janeiro, Lab Morphometry & Cardiovasc Morphol, Biomed Ctr, Inst Biol, 28 Setembro,87 Fds, BR-20551030 Rio De Janeiro, Brazil.
EM mandarim@uerj.br
RI AQUINO, JULIO/ABG-8977-2020; Mandarim-de-Lacerda, Carlos/F-7125-2012;
   Aguila, Marcia/P-2349-2019; Mandarim-de-Lacerda, Carlos/P-2360-2019;
   Fernandes-Santos, Caroline/M-1794-2019
OI Mandarim-de-Lacerda, Carlos/0000-0003-4134-7978; Fernandes-Santos,
   Caroline/0000-0002-2420-3836; Barbosa Aguila, Marcia/0000-0003-3994-4589
FU CNPq (Brazilian Council of Science and Technology); FAPERJ (Rio de
   Janeiro State Foundation for Scientific Research)
FX This work was supported by the agencies CNPq (Brazilian Council of
   Science and Technology, www.cnpq.br) and FAPERJ (Rio de Janeiro State
   Foundation for Scientific Research, www.faperj.br).
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NR 52
TC 351
Z9 392
U1 0
U2 45
PU JOURNAL CLINICAL BIOCHEMISTRY & NUTRITION
PI KYOTO
PA KYOTO PREFECTURAL UNIV MED, GRAD SCH MEDICAL SCIENCE, DEPT MOLECULAR
   GASTROENTEROLOGY & HEPATOLOGY, KYOTO, 602-8566, JAPAN
SN 0912-0009
EI 1880-5086
J9 J CLIN BIOCHEM NUTR
JI J. Clin. Biochem. Nutr.
PD MAY
PY 2010
VL 46
IS 3
BP 212
EP 223
DI 10.3164/jcbn.09-83
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 612MS
UT WOS:000278903500004
PM 20490316
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Althoff, M
   Holguin, F
AF Althoff, Meghan
   Holguin, Fernando
TI Contemporary management techniques of asthma in obese patients
SO EXPERT REVIEW OF RESPIRATORY MEDICINE
LA English
DT Review
DE Asthma; obesity; treatment; oxidative stress; diet
ID BODY-MASS INDEX; QUALITY-OF-LIFE; C-REACTIVE PROTEIN; FACTOR-KAPPA-B;
   WEIGHT-LOSS; BARIATRIC SURGERY; AIRWAY INFLAMMATION; METABOLIC SYNDROME;
   LUNG-FUNCTION; SYSTEMIC INFLAMMATION
AB Introduction: Obesity-associated asthma represents a heterogeneous group of clinical phenotypes, including an adult-onset phenotype. These patients often have difficult to control symptoms and often are less likely to respond to conventional asthma therapies. Areas covered: This review covers the effects of lifestyle interventions, including diet and weight loss, effect asthma outcomes and how obesity-associated asthma responds to conventional approaches to asthma management. Expert opinion: Management of obesity-associated asthma should include lifestyle modifications aimed at weight reduction, management of other co-morbidities, and limiting systemic steroids. As many of these patients have non-Th2 asthma, long-acting muscarinic antagonists and macrolides may be potentially helpful. Medications to treat metabolic syndrome.
C1 [Althoff, Meghan; Holguin, Fernando] Univ Colorado, Pulm Sci & Crit Care, Denver, CO 80202 USA.
C3 University of Colorado System; University of Colorado Denver
RP Holguin, F (corresponding author), Univ Colorado, Pulm Sci & Crit Care, Denver, CO 80202 USA.
EM Fernando.holguin@cuanschutz.edu
FU U.S. Department of Health and Human Services, National Institutes of
   Health, National Heart, Lung, and Blood Institute [HL146542-01]
FX This paper was funded by the U.S. Department of Health and Human
   Services, National Institutes of Health, National Heart, Lung, and Blood
   Institute (HL146542-01)
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NR 95
TC 4
Z9 4
U1 0
U2 2
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1747-6348
EI 1747-6356
J9 EXPERT REV RESP MED
JI Expert Rev. Respir. Med.
PD MAR 3
PY 2020
VL 14
IS 3
BP 249
EP 257
DI 10.1080/17476348.2020.1706486
EA DEC 2019
PG 9
WC Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Respiratory System
GA KO4VQ
UT WOS:000504197400001
PM 31852311
DA 2025-06-11
ER

PT J
AU Hoirisch-Clapauch, S
AF Hoirisch-Clapauch, Silvia
TI Mechanisms affecting brain remodeling in depression: do all roads lead
   to impaired fibrinolysis?
SO MOLECULAR PSYCHIATRY
LA English
DT Review
ID TISSUE-PLASMINOGEN-ACTIVATOR; INSULIN-RESISTANCE; INTESTINAL MICROBIOTA;
   METABOLIC SYNDROME; DOPAMINE RELEASE; GENE-EXPRESSION; MOOD DISORDERS;
   INHIBITOR GENE; DISEASE; INTERLEUKIN-6
AB Fibrinolysis occurs when plasminogen activators, such as tissue plasminogen activator (tPA), convert plasminogen to plasmin, which dissolves the fibrin clot. The proteolytic activity of tPA and plasmin is not restricted to fibrin degradation. In the extravascular space, these two proteases modify a variety of substrates other than fibrin, playing a crucial role in physiological and pathological tissue remodeling. In the brain, for example, tPA and plasmin mediate the conversion of brain-derived neurotrophic factor precursor (proBDNF) to mature brain-derived neurotrophic factor precursor (BDNF). Thus, the fibrinolytic system influences processes reported to be dysfunctional in depression, including neurogenesis, synaptic plasticity, and reward processing. The hypothesis that decreased fibrinolytic activity is an important element in the pathogenesis of depression is supported by the association between depression and increased levels of plasminogen activator inhibitor (PAI)-1, the main inhibitor of tPA. Also, various biochemical markers of depression induce PAI-1 synthesis, including hypercortisolism, hyperinsulinemia, hyperleptinemia, increased levels of cytokines, and hyperhomocysteinemia. Moreover, hypofibrinolysis provides a link between depression and emotional eating, binge eating, vegetarianism, and veganism. This paper discusses the role of reduced fibrinolytic activity in the bidirectional interplay between depression and its somatic manifestations and complications. It also reviews evidence that abnormal fibrinolysis links heterogeneous conditions associated with treatment-resistant depression. Understanding the role of hypofibrinolysis in depression may open new avenues for its treatment.
C1 [Hoirisch-Clapauch, Silvia] Minist Hlth, Hosp Fed Servidores Estado, Rio De Janeiro, Brazil.
RP Hoirisch-Clapauch, S (corresponding author), Minist Hlth, Hosp Fed Servidores Estado, Rio De Janeiro, Brazil.
EM sclapauch@gmail.com
RI Hoirisch-Clapauch, Silvia/F-3813-2018
OI Hoirisch-Clapauch, Silvia/0000-0003-2453-4915
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NR 130
TC 20
Z9 21
U1 0
U2 10
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 1359-4184
EI 1476-5578
J9 MOL PSYCHIATR
JI Mol. Psychiatr.
PD JAN
PY 2022
VL 27
IS 1
BP 525
EP 533
DI 10.1038/s41380-021-01264-1
EA AUG 2021
PG 9
WC Biochemistry & Molecular Biology; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Biochemistry & Molecular Biology; Neurosciences & Neurology; Psychiatry
GA 0K0HD
UT WOS:000685717900001
PM 34404914
DA 2025-06-11
ER

PT J
AU Esmaeelpanah, E
   Razavi, BM
   Hosseinzadeh, H
AF Esmaeelpanah, Elahe
   Razavi, Bibi Marjan
   Hosseinzadeh, Hossein
TI Green tea and metabolic syndrome: A 10-year research update review
SO IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
LA English
DT Review
DE Diabetes; Dyslipidemia; Green tea; Hypertension; Metabolic syndrome;
   Obesity
ID REDUCES BLOOD-PRESSURE; DIET-INDUCED OBESITY; (-)-EPIGALLOCATECHIN
   GALLATE EGCG; AMELIORATES INSULIN-RESISTANCE; DECREASES OXIDATIVE
   STRESS; FATTY LIVER-DISEASE; EPIGALLOCATECHIN GALLATE; ADIPOSE-TISSUE;
   POLYPHENOL EPIGALLOCATECHIN-3-GALLATE; DOUBLE-BLIND
AB Metabolic syndrome (MetS) has turned into a prevalent condition that has imposed a tremendous financial strain on public health care systems. It is believed that the MetS consists of four main factors (hypertension, dyslipidemia, hyperglycemia, and obesity) and may lead to cardiovascular events. Camellia sinesis, in the form of green tea (GT), is one of the most consuming beverages worldwide. Catechins are the dominant component of green tea leaves. Epigallocatechin gallate has the maximum potency. GT has been widely used as a supplement in various health conditions. As the oxidative stress pathway is one of the probable mechanisms of MetS etiologies and GT beneficial effects, GT may be a novel strategy to overcome the MetS. This review aims to reveal the probable pharmacological effects of GT on MetS. The last 10-year original articles on MetS parameters and GT have been gathered in this review. This manuscript has summarized the probable effects of green tea and its catechins on MetS and focused on each different aspect of MetS separately, which can be used as a basis for further investigations for introducing effective compounds as a way to interfere with MetS.
   It seems that GT can reduce MetS parameters commonly via anti-inflammatory and anti-oxidative mechanisms. Further clinical trials are needed to confirm the use of GT and its constituents for the treatment of MetS.
C1 [Esmaeelpanah, Elahe; Razavi, Bibi Marjan; Hosseinzadeh, Hossein] Mashhad Univ Med Sci, Sch Pharm, Dept Pharmacodynam & Toxicol, Mashhad, Razavi Khorasan, Iran.
   [Razavi, Bibi Marjan] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Targeted Drug Delivery Res Ctr, Mashhad, Razavi Khorasan, Iran.
   [Hosseinzadeh, Hossein] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Pharmaceut Res Ctr, Mashhad, Razavi Khorasan, Iran.
C3 Mashhad University of Medical Sciences; Mashhad University of Medical
   Sciences; Mashhad University of Medical Sciences
RP Hosseinzadeh, H (corresponding author), Mashhad Univ Med Sci, Sch Pharm, Dept Pharmacodynam & Toxicol, Mashhad, Razavi Khorasan, Iran.; Hosseinzadeh, H (corresponding author), Mashhad Univ Med Sci, Pharmaceut Technol Inst, Pharmaceut Res Ctr, Mashhad, Razavi Khorasan, Iran.
EM hosseinzadehh@mums.ac.ir
RI Razavi, Bibi/AAY-5636-2020; Hosseinzadeh, Hossein/F-3013-2010
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NR 154
TC 9
Z9 9
U1 0
U2 17
PU MASHHAD UNIV MED SCIENCES
PI MASHHAD
PA VICE-CHANCELLOR FOR RES CTR OFF IJBMS, DANESHGAH ST, PO BOX 9138813944 -
   445, MASHHAD, 00000, IRAN
SN 2008-3866
EI 2008-3874
J9 IRAN J BASIC MED SCI
JI Iran. J. Basic Med. Sci.
PD SEP
PY 2021
VL 24
IS 9
BP 1159
EP 1172
PG 14
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA UL3NM
UT WOS:000692562000001
PM 35083002
DA 2025-06-11
ER

PT J
AU Yanai, H
   Adachi, H
   Hakoshima, M
   Iida, S
   Katsuyama, H
AF Yanai, Hidekatsu
   Adachi, Hiroki
   Hakoshima, Mariko
   Iida, Sakura
   Katsuyama, Hisayuki
TI A Possible Therapeutic Application of the Selective Inhibitor of Urate
   Transporter 1, Dotinurad, for Metabolic Syndrome, Chronic Kidney
   Disease, and Cardiovascular Disease
SO CELLS
LA English
DT Review
DE ATP-binding cassette transporter G2; chronic kidney disease; dotinurad;
   hyperuricemia; organic anion transporter1/3; urate transporter 1
ID SERUM URIC-ACID; OXIDATIVE STRESS; RENAL-FUNCTION; ENDOTHELIAL
   DYSFUNCTION; INSULIN-RESISTANCE; HEPATIC STEATOSIS; BLOOD-PRESSURE;
   RISK-FACTOR; ALLOPURINOL; HYPERURICEMIA
AB The reabsorption of uric acid (UA) is mainly mediated by urate transporter 1 (URAT1) and glucose transporter 9 (GLUT9) in the kidneys. Dotinurad inhibits URAT1 but does not inhibit other UA transporters, such as GLUT9, ATP-binding cassette transporter G2 (ABCG2), and organic anion transporter 1/3 (OAT1/3). We found that dotinurad ameliorated the metabolic parameters and renal function in hyperuricemic patients. We consider the significance of the highly selective inhibition of URAT1 by dotinurad for metabolic syndrome, chronic kidney disease (CKD), and cardiovascular disease (CVD). The selective inhibition of URAT1 by dotinurad increases urinary UA in the proximal tubules, and this un-reabsorbed UA may compete with urinary glucose for GLUT9, reducing glucose reabsorption. The inhibition by dotinurad of UA entry via URAT1 into the liver and adipose tissues increased energy expenditure and decreased lipid synthesis and inflammation in rats. Such effects may improve metabolic parameters. CKD patients accumulate uremic toxins, including indoxyl sulfate (IS), in the body. ABCG2 regulates the renal and intestinal excretion of IS, which strongly affects CKD. OAT1/3 inhibitors suppress IS uptake into the kidneys, thereby increasing plasma IS, which produces oxidative stress and induces vascular endothelial dysfunction in CKD patients. The highly selective inhibition of URAT1 by dotinurad may be beneficial for metabolic syndrome, CKD, and CVD.
C1 [Yanai, Hidekatsu; Adachi, Hiroki; Hakoshima, Mariko; Iida, Sakura; Katsuyama, Hisayuki] Kohnodai Hosp, Natl Ctr Global Hlth & Med, Dept Diabet Endocrinol & Metab, 1-7-1 Kohnodai, Ichikawa, Chiba 2728516, Japan.
C3 Japan Institute for Health Security (JIHS); National Center for Global
   Health & Medicine - Japan
RP Yanai, H (corresponding author), Kohnodai Hosp, Natl Ctr Global Hlth & Med, Dept Diabet Endocrinol & Metab, 1-7-1 Kohnodai, Ichikawa, Chiba 2728516, Japan.
EM dyanai@hospk.ncgm.go.jp; dadachidm@hospk.ncgm.go.jp;
   d-hakoshima@hospk.ncgm.go.jp; d-20iida@hospk.ncgm.go.jp;
   d-katsuyama@hospk.ncgm.go.jp
RI Yanai, Hidekatsu/AFN-9517-2022
OI Yanai, Hidekatsu/0000-0002-4199-3665; Katsuyama,
   Hisayuki/0000-0003-2871-8340
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NR 146
TC 8
Z9 8
U1 13
U2 22
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2073-4409
J9 CELLS-BASEL
JI Cells
PD MAR
PY 2024
VL 13
IS 5
AR 450
DI 10.3390/cells13050450
PG 24
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA KV2Y3
UT WOS:001182685100001
PM 38474414
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Fields, CT
   Chassaing, B
   de Vries, GJ
AF Fields, Christopher T.
   Chassaing, Benoit
   de Vries, Geert J.
TI Gut barrier dysfunction and type 2 immunity: Implications for compulsive
   behavior
SO MEDICAL HYPOTHESES
LA English
DT Article
DE Type 2 inflammation; Compulsive behavior; Gut barrier dysfunction;
   Gut-brain axis; Autism spectrum disorders; Addiction
ID TOURETTE SYNDROME; SEX-DIFFERENCES; HISTIDINE-DECARBOXYLASE; INTESTINAL
   PERMEABILITY; REPETITIVE BEHAVIOR; SPECTRUM DISORDERS; METABOLIC
   SYNDROME; ALLERGIC DISEASE; VAGAL PATHWAYS; ANIMAL-MODELS
AB To date, much of the focus of gut-brain axis research has been on gut microbiota regulation of anxiety and stressrelated behaviors. Much less attention has been directed to potential connections between gut microbiota and compulsive behavior. Here, we discuss a potential link between gut barrier dysfunction and compulsive behavior that is mediated through "type 2" rather than "type 1" inflammation. We examine connections between compulsive behavior and type 2 inflammation in Tourette syndrome, obsessive-compulsive disorder, autism, addiction, and post-traumatic stress disorder. Next, we discuss potential connections between gut barrier dysfunction, type 2 inflammation, and compulsive behavior. We posit a potential mechanism whereby gut barrier dysfunction-associated type 2 inflammation may drive compulsive behavior through histamine regulation of dopamine neurotransmission. Finally, we discuss the possibility of exploiting the greater accessibility of the gut relative to the brain in identifying targets to treat compulsive behavior disorders.
C1 [Fields, Christopher T.] Yale Univ, Dept Psychiat, New Haven, CT 06519 USA.
   [Chassaing, Benoit] Univ Paris, Team Mucosal Microbiota Chron Inflammatory Dis, Inserm U1016, CNRS UMR 8104, F-75014 Paris, France.
   [de Vries, Geert J.] Georgia State Univ, Dept Biol, Atlanta, GA 30303 USA.
   [de Vries, Geert J.] Georgia State Univ, Neurosci Inst, Atlanta, GA 30303 USA.
C3 Yale University; Universite Paris Cite; Institut National de la Sante et
   de la Recherche Medicale (Inserm); Centre National de la Recherche
   Scientifique (CNRS); CNRS - National Institute for Biology (INSB);
   University System of Georgia; Georgia State University; University
   System of Georgia; Georgia State University
RP Fields, CT (corresponding author), Yale Univ, Dept Psychiat, New Haven, CT 06519 USA.
EM christopher.fields@yale.edu; benoit.chassaing@inserm.fr; devries@gsu.edu
RI Chassaing, Benoit/R-3819-2017
OI Fields, Christopher/0000-0002-2054-7316; de Vries, Geert
   J./0000-0002-1263-3775
FU NIH [MH112369, MH108345]
FX This work was supported by NIH Grant No. MH112369 (to CTF) and MH108345
   (to GJD) . The authors report no biomedical financial interest or
   potential conflicts of interest.
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NR 190
TC 2
Z9 2
U1 0
U2 19
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0306-9877
EI 1532-2777
J9 MED HYPOTHESES
JI Med. Hypotheses
PD APR
PY 2022
VL 161
AR 110799
DI 10.1016/j.mehy.2022.110799
EA FEB 2022
PG 12
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Research & Experimental Medicine
GA ZO2UY
UT WOS:000765586700008
PM 36060122
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Lee, IS
   Ko, SJ
   Lee, YN
   Lee, G
   Rahman, H
   Kim, B
AF Lee, In-Seon
   Ko, Seok-Jae
   Lee, Yu Na
   Lee, Gahyun
   Rahman, Hasanur
   Kim, Bonglee
TI The Effect of Laminaria japonica on Metabolic Syndrome: A
   Systematic Review of Its Efficacy and Mechanism of Action
SO NUTRIENTS
LA English
DT Review
DE metabolic syndrome; Laminaria japonica; atherosclerosis; diabetes;
   obesity; AMPK
ID HIGH-FAT DIET; MOLECULAR-WEIGHT FUCOIDAN; OXIDATIVE STRESS; GUT
   MICROBIOTA; PHYSICOCHEMICAL PROPERTIES; HYPOLIPIDEMIC ACTIVITIES;
   INSULIN-RESISTANCE; LIPID-METABOLISM; BROWN SEAWEEDS; NITRIC-OXIDE
AB Metabolic syndrome (MetS) is a medical condition characterized by abdominal obesity, insulin resistance, high blood pressure, and hyperlipidemia. An increase in the incidence of MetS provokes an escalation in health care costs and a downturn in quality of life. However, there is currently no cure for MetS, and the absence of immediate treatment for MetS has prompted the development of novel therapies. In accordance with recent studies, the brown seaweed Laminaria japonica (LJP) has anti-inflammatory and antioxidant properties, and so forth. LJP contains bioactive compounds used as food globally, and it has been used as a medicine in East Asian countries. We conducted a systematic review to examine whether LJP could potentially be a useful therapeutic drug for MetS. The following databases were searched from initiation to September 2021: PubMed, Web of Science, EMBASE, and Cochrane Central Register of Controlled Trials Library. Clinical trials and in vivo studies evaluating the effects of LJP on MetS were included. LJP reduces the oxidative stress-related lipid mechanisms, inflammatory cytokines and macrophage-related chemokines, muscle cell proliferation, and migration. Bioactive-glucosidase inhibitors reduce diabetic complications, a therapeutic target in obesity and type 2 diabetes. In obesity, LJP increases AMP-activated protein kinase and decreases acetyl-CoA carboxylase. Based on our findings, we suggest that LJP could treat MetS, as it has pharmacological effects on MetS.
C1 [Lee, In-Seon] Kyung Hee Univ, Coll Korean Med, Dept Meridians & Acupoints, Seoul 05253, South Korea.
   [Lee, In-Seon] Kyung Hee Univ, Acupuncture & Meridian Sci Res Ctr, Seoul 02447, South Korea.
   [Ko, Seok-Jae] Kyung Hee Univ, Coll Korean Med, Dept Gastroenterol, Seoul 05253, South Korea.
   [Lee, Yu Na; Lee, Gahyun; Rahman, Hasanur; Kim, Bonglee] Kyung Hee Univ, Coll Korean Med, Seoul 05253, South Korea.
C3 Kyung Hee University; Kyung Hee University; Kyung Hee University; Kyung
   Hee University
RP Kim, B (corresponding author), Kyung Hee Univ, Coll Korean Med, Seoul 05253, South Korea.
EM inseon.lee@khu.ac.kr; kokoko119@khu.ac.kr; unaly@khu.ac.kr;
   dlrkgus177@khu.ac.kr; hasanurrahman.bge@gmail.com; bongleekim@khu.ac.kr
RI Rahman, Hasanur/AAX-4023-2020; Lee, Ho-jeong/S-4934-2019; Kim,
   Bonglee/AAH-9077-2020; Lee, In-Seon/AAM-1252-2020
OI Rahman, MD. Hasanur/0000-0001-9238-3149; Kim,
   Bonglee/0000-0002-8678-156X; Lee, In-Seon/0000-0001-9275-3111
FU National Research Foundation of Korea (NRF) - Korean government (MSIT)
   [2020R1A5A2019413, 2020R1A4A1018598, 2022R1C1C1004937]; Basic Science
   Research Program through the National Research Foundation of Korea (NRF)
   - Ministry of Education [NRF-2020R1I1A2066868]
FX This research was supported by a National Research Foundation of Korea
   (NRF) grant funded by the Korean government (MSIT) (No.
   2022R1C1C1004937), the Basic Science Research Program through the
   National Research Foundation of Korea (NRF) funded by the Ministry of
   Education (NRF-2020R1I1A2066868), and a National Research Foundation of
   Korea (NRF) grant funded by the Korean government (MSIT) (Nos.
   2020R1A5A2019413, 2020R1A4A1018598).
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NR 84
TC 6
Z9 6
U1 3
U2 24
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD AUG
PY 2022
VL 14
IS 15
AR 3046
DI 10.3390/nu14153046
PG 25
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 3S8AQ
UT WOS:000839812900001
PM 35893900
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Pingitore, A
   Gaggini, M
   Mastorci, F
   Sabatino, L
   Cordiviola, L
   Vassalle, C
AF Pingitore, Alessandro
   Gaggini, Melania
   Mastorci, Francesca
   Sabatino, Laura
   Cordiviola, Linda
   Vassalle, Cristina
TI Metabolic Syndrome, Thyroid Dysfunction, and Cardiovascular Risk: The
   Triptych of Evil
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE metabolic syndrome; thyroid hormones; thyroid dysfunction;
   cardiovascular risk; endothelial dysfunction; atherosclerosis
ID HORMONE RECEPTOR-BETA; BROWN ADIPOSE-TISSUE; SUBCLINICAL HYPOTHYROIDISM;
   OXIDATIVE STRESS; BLOOD-PRESSURE; INSULIN-RESISTANCE; PROVISIONAL
   REPORT; MORTALITY; TRIIODOTHYRONINE; HYPERTHYROIDISM
AB The triad formed by thyroid dysfunction, metabolic syndrome (MetS), and cardiovascular (CV) risk forms a network with many connections that aggravates health outcomes. Thyroid hormones (THs) play an important role in glucose and lipid metabolism and hemodynamic regulation at the molecular level. It is noteworthy that a bidirectional association between THs and MetS and their components likely exists as MetS leads to thyroid dysfunction, whereas thyroid alterations may cause a higher incidence of MetS. Thyroid dysfunction increases insulin resistance, the circulating levels of lipids, in particular LDL-C, VLDL-C, and triglycerides, and induces endothelial dysfunction. Furthermore, THs are important regulators of both white and brown adipose tissue. Moreover, the pathophysiological relationship between MetS and TH dysfunction is made even tighter considering that these conditions are usually associated with inflammatory activation and increased oxidative stress. Therefore, the role of THs takes place starting from the molecular level, then manifesting itself at the clinical level, through an increased risk of CV events in the general population as well as in patients with heart failure or acute myocardial infarction. Thus, MetS is frequently associated with thyroid dysfunction, which supports the need to assess thyroid function in this group, and when clinically indicated, to correct it to maintain euthyroidism. However, there are still several critical points to be further investigated both at the molecular and clinical level, in particular considering the need to treat subclinical dysthyroidism in MetS patients.
C1 [Pingitore, Alessandro; Gaggini, Melania; Mastorci, Francesca; Sabatino, Laura] CNR, Clin Physiol Inst, I-56124 Pisa, Italy.
   [Cordiviola, Linda] Pisa Univ, Dept Pharm, I-56126 Pisa, Italy.
   [Vassalle, Cristina] Fdn G Monasterio, Reg Toscana, I-56124 Pisa, Italy.
C3 Consiglio Nazionale delle Ricerche (CNR); University of Pisa
RP Pingitore, A (corresponding author), CNR, Clin Physiol Inst, I-56124 Pisa, Italy.
EM alessandro.pingitore@cnr.it; melania.gaggini@cnr.it;
   francesca.mastorci@cnr.it; laura.sabatino@cnr.it;
   l.cordiviola1@studenti.unipi.it; cricca@ftgm.it
RI Pingitore, Alessandro/K-1843-2018; Sabatino, Laura/AAX-8985-2020;
   Gaggini, Melania/C-9379-2017
OI Gaggini, Melania/0000-0002-6311-502X; VASSALLE,
   CRISTINA/0000-0003-3438-6450; Sabatino, Laura/0000-0002-9283-5042
FX This research received no external funding.
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NR 144
TC 3
Z9 3
U1 2
U2 3
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD OCT
PY 2024
VL 25
IS 19
AR 10628
DI 10.3390/ijms251910628
PG 16
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA I7Y7R
UT WOS:001332382200001
PM 39408957
OA gold
DA 2025-06-11
ER

PT J
AU Medina-Julio, D
   Ramírez-Mejía, MM
   Cordova-Gallardo, J
   Peniche-Luna, E
   Cantú-Brito, C
   Méndez-Sánchez, N
AF Medina-Julio, David
   Ramirez-Mejia, Mariana M.
   Cordova-Gallardo, Jacqueline
   Peniche-Luna, Emilio
   Cantu-Brito, Carlos
   Mendez-Sanchez, Nahum
TI From Liver to Brain: How MAFLD/MASLD Impacts Cognitive Function
SO MEDICAL SCIENCE MONITOR
LA English
DT Article
DE Abdominal Obesity Metabolic Syndrome; Cognitive Dysfunction; Insulin
   Resistance; Metabolic Syndrome; Non-Alcoholic Fatty Liver Disease;
   Oxidative Stress
ID FATTY LIVER; INSULIN-RESISTANCE; METABOLIC SYNDROME; GUT MICROBIOTA;
   DISEASE; INFLAMMATION; FRUCTOSE; STRESS; AXIS; ASSOCIATION
AB Metabolic dysfunction -associated fatty liver disease or metabolic dysfunction -associated steatotic liver disease (MAFLD/MASLD), is a common chronic liver condition affecting a substantial global population. Beyond its primary impact on liver function, MAFLD/MASLD is associated with a myriad of extrahepatic manifestations, including cognitive impairment. The scope of cognitive impairment within the realm of MAFLD/MASLD is a matter of escalating concern. Positioned as an intermediate stage between the normal aging process and the onset of dementia, cognitive impairment manifests as a substantial challenge associated with this liver condition. Insights from studies underscore the presence of compromised executive function and a global decline in cognitive capabilities among individuals identified as being at risk of progressing to liver fibrosis. Importantly, this cognitive impairment transcends mere association with metabolic factors, delving deep into the intricate pathophysiology characterizing MAFLD/MASLD. The multifaceted nature of cognitive impairment in the context of MAFLD/MASLD is underlined by a spectrum of factors, prominently featuring insulin resistance, lipotoxicity, and systemic inflammation as pivotal contributors. These factors interplay within the intricate landscape of MAFLD/MASLD, fostering a nuanced understanding of the links between hepatic health and cognitive function. By synthesizing the available evidence, exploring potential mechanisms, and assessing clinical implications, the overarching aim of this review is to contribute to a more complete understanding of the impact of MAFLD/MASLD on cognitive function.
C1 [Medina-Julio, David] Gen Hosp Dr Manuel Gea Gonzalez, Dept Internal Med, Mexico City, Mexico.
   [Cordova-Gallardo, Jacqueline; Cantu-Brito, Carlos; Mendez-Sanchez, Nahum] Univ Nacl Autonoma Mexico, Fac Med, Mexico City, Mexico.
   [Ramirez-Mejia, Mariana M.; Mendez-Sanchez, Nahum] Med Sur Clin & Fdn, Liver Unit, Mexico City, Mexico.
   [Ramirez-Mejia, Mariana M.] Univ Nacl Autonoma Mexico, Fac Med, Plan Combined Studies Med, Mexico City, Mexico.
   [Cordova-Gallardo, Jacqueline] Gen Hosp Dr Manuel Gea Gonzalez, Dept Hepatol, Serv Surg & Obes Clin, Mexico City, Mexico.
   [Peniche-Luna, Emilio] Univ Nacl Autonoma Mexico, Fac Med, High Acad Performance Program PAEA, Mexico City, Mexico.
   [Cantu-Brito, Carlos] Natl Inst Med Sci & Nutr Salvador Zubiran, Dept Neurol, Mexico City, Mexico.
C3 Universidad Nacional Autonoma de Mexico; Universidad Nacional Autonoma
   de Mexico; Universidad Nacional Autonoma de Mexico
RP Méndez-Sánchez, N (corresponding author), Univ Nacl Autonoma Mexico, Fac Med, Mexico City, Mexico.; Méndez-Sánchez, N (corresponding author), Med Sur Clin & Fdn, Liver Unit, Mexico City, Mexico.
RI CANTU BRITO, CARLOS/LZH-6832-2025
FU Consejo Nacional de Humanidades, Ciencias y Tecnologias (CONAHCYT)
FX The scholarships granted by Consejo Nacional de Humanidades, Ciencias y
   Tecnologias (CONAHCYT) made it possible for David Medina-Julio and
   Mariana M Ramirez-Mejia to undertake post-graduate studies, enriching
   their academic and professional development.
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NR 117
TC 15
Z9 15
U1 3
U2 7
PU INT SCIENTIFIC INFORMATION, INC
PI MELVILLE
PA 150 BROADHOLLOW RD, STE 114, MELVILLE, NY 11747 USA
EI 1643-3750
J9 MED SCI MONITOR
JI Med. Sci. Monitor
PD MAR 18
PY 2024
VL 30
AR e943417
DI 10.12659/MSM.943417
PG 13
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA PY9F9
UT WOS:001217750300001
PM 38282346
OA Green Published
DA 2025-06-11
ER

PT J
AU Senaphan, K
   Kukongviriyapan, U
   Sangartit, W
   Pakdeechote, P
   Pannangpetch, P
   Prachaney, P
   Greenwald, SE
   Kukongviriyapan, V
AF Senaphan, Ketmanee
   Kukongviriyapan, Upa
   Sangartit, Weerapon
   Pakdeechote, Poungrat
   Pannangpetch, Patchareewan
   Prachaney, Parichat
   Greenwald, Stephen E.
   Kukongviriyapan, Veerapol
TI Ferulic Acid Alleviates Changes in a Rat Model of Metabolic Syndrome
   Induced by High-Carbohydrate, High-Fat Diet
SO NUTRIENTS
LA English
DT Article
ID ENDOTHELIAL DYSFUNCTION; INSULIN-RESISTANCE; OXIDATIVE STRESS; RICE
   BRAN; TETRAHYDROCURCUMIN; PATHOPHYSIOLOGY; BIOCHEMISTRY; CHEMISTRY;
   CURCUMIN; GLUCOSE
AB Metabolic syndrome is a cluster of metabolic abnormalities characterized by obesity, insulin resistance, hypertension and dyslipidemia. Ferulic acid (FA) is the major phenolic compound found in rice oil and various fruits and vegetables. In this study, we examined the beneficial effects of FA in minimizing insulin resistance, vascular dysfunction and remodeling in a rat model of high-carbohydrate, high-fat diet-induced metabolic changes, which is regarded as an analogue of metabolic syndrome (MS) in man. Male Sprague-Dawley rats were fed a high carbohydrate, high fat (HCHF) diet and 15% fructose in drinking water for 16 weeks, where control rats were fed with standard chow diet and tap water. FA (30 or 60 mg/kg) was orally administered to the HCHF and control rats during the last six weeks of the study. We observed that FA significantly improved insulin sensitivity and lipid profiles, and reduced elevated blood pressure, compared to untreated controls (p < 0.05). Moreover, FA also improved vascular function and prevented vascular remodeling of mesenteric arteries. The effects of FA in HCHF-induced MS may be realized through suppression of oxidative stress by down-regulation of p47phox, increased nitric oxide (NO) bioavailability with up-regulation of endothelial nitric oxide synthase (eNOS) and suppression of tumor necrosis factor-alpha (TNF-alpha). Our results suggest that supplementation of FA may have health benefits by minimizing the cardiovascular complications of MS and alleviating its symptoms.
C1 [Senaphan, Ketmanee; Kukongviriyapan, Upa; Sangartit, Weerapon; Pakdeechote, Poungrat] Khon Kaen Univ, Fac Med, Dept Physiol, Khon Kaen 40002, Thailand.
   [Pannangpetch, Patchareewan; Kukongviriyapan, Veerapol] Khon Kaen Univ, Fac Med, Dept Pharmacol, Khon Kaen 40002, Thailand.
   [Prachaney, Parichat] Khon Kaen Univ, Fac Med, Dept Anat, Khon Kaen 40002, Thailand.
   [Greenwald, Stephen E.] Queen Mary Univ London, Barts & London Sch Med & Dent, Blizard Inst, London E1 2ES, England.
C3 Khon Kaen University; Khon Kaen University; Khon Kaen University;
   University of London; Queen Mary University London
RP Kukongviriyapan, U (corresponding author), Khon Kaen Univ, Fac Med, Dept Physiol, Khon Kaen 40002, Thailand.
EM ketmanee.879@gmail.com; upa_ku@kku.ac.th; weerapons@kkumail.com;
   ppoung@kku.ac.th; patc_pan@kku.ac.th; parpra@kku.ac.th;
   s.e.greenwald@qmul.ac.uk; veerapol@kku.ac.th
RI Greenwald, Stephen/C-6928-2012
OI Sangartit, Weerapon/0000-0002-5058-2294; Greenwald,
   Stephen/0000-0002-8471-7070
FU Agricultural Research Development Agency Fund; Thailand Research Fund;
   Khon Kaen University Research Fund; Invitation Research Fund, Faculty of
   Medicine, Khon Kaen University; Royal Golden Jubilee PhD Program, the
   Thailand Research Fund [PHD/0048/2553]
FX This work was supported by grants from the Agricultural Research
   Development Agency Fund, the Thailand Research Fund, the Khon Kaen
   University Research Fund and the Invitation Research Fund, Faculty of
   Medicine, Khon Kaen University. Senaphan K. was supported by a
   scholarship (PHD/0048/2553) from the Royal Golden Jubilee PhD Program,
   the Thailand Research Fund.
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NR 37
TC 80
Z9 84
U1 1
U2 42
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD AUG
PY 2015
VL 7
IS 8
BP 6446
EP 6464
DI 10.3390/nu7085283
PG 19
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA CQ4PQ
UT WOS:000360587500024
PM 26247970
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Paliwal, S
   Jain, S
   Mudgal, P
   Verma, K
   Paliwal, S
   Sharma, S
AF Paliwal, Swati
   Jain, Smita
   Mudgal, Pallavi
   Verma, Kanika
   Paliwal, Sarvesh
   Sharma, Swapnil
TI Mitochondrial transfer restores impaired liver functions by
   AMPK/mTOR/PI3K-AKT pathways in metabolic syndrome
SO LIFE SCIENCES
LA English
DT Article
DE Metabolic syndrome; Mitochondria transplantation; Metabolic
   reprogramming; Fatty-acid beta oxidation; Mitochondrial bioenergetics
ID INSULIN-RESISTANCE; OXIDATIVE STRESS; SKELETAL-MUSCLE; TRANSPLANTATION;
   DYSFUNCTION; HEART; PROTECTS; MICE
AB Aim: We investigated the effect of mitochondria transfer in high fat diet and streptozotocin (HFD + STZ) induced metabolic syndrome (MeS) in rats. The effect of mitochondria transfer in MeS with co-existing hypertension, hyperlipidaemia, diabetes and fatty liver together, has not been reported.Materials and methods: Heathy mitochondria was transferred intravenously and the effect on several physiological parameters and biochemical parameters were examined in HFD + STZ rats. In addition, RNA-sequencing of healthy liver tissues was performed to elucidate the molecular pathways affected by mitochondria transfer in restoring metabolic health.Key findings: We observed reduction in both systolic and diastolic blood pressure levels, reduced blood glucose levels, and a marked reduction in serum lipid profiles. The levels of alanine transaminase (ALT) and aspartate transaminase (AST) also improved along with evident restoration of liver morphology demonstrated by histopathological analysis. Enhanced mitochondrial biogenetics and reduction in oxidative stress and inflammatory markers was also observed. The pathway enrichment analysis revealed reduction in insulin resistance, inflammatory markers, regulation of mitochondrial bioenergetics, calcium ion homeostasis, fatty-acid beta-oxidation, cytokine immune regulators, and enhanced lipid solubilisation. The significant effect of healthy mitochondria transfer in restoration of metabolic functions was observed by the activation of PI3K-AKT, AMPK/mTOR pathways and cytokine immune regulators, suggesting that inflammatory mediators were also significantly affected after mitochondria transfer.Significance: This study, provides insights on molecular processes triggered by mitochondria transfer in fatty liver regeneration and improvement of overall metabolic health.
C1 [Paliwal, Swati; Mudgal, Pallavi] Banasthali Vidyapith, Dept Biosci & Biotechnol, Banasthali 304022, Rajasthan, India.
   [Jain, Smita; Verma, Kanika; Paliwal, Sarvesh; Sharma, Swapnil] Banasthali Vidyapith, Dept Pharm, Banasthali 304022, Rajasthan, India.
C3 Banasthali Vidyapith; Banasthali Vidyapith
RP Paliwal, S (corresponding author), Banasthali Vidyapith, Dept Biosci & Biotechnol, Banasthali 304022, Rajasthan, India.
EM swatipaliwal@banasthali.in
RI Verma, Kanika/GZA-3489-2022; Paliwal, Sarvesh/GQQ-1555-2022; Paliwal,
   Swati/HGA-7665-2022; Jain, Smita/KLB-9548-2024; Sharma,
   Swapnil/AAV-4850-2020
OI Paliwal, Swati/0000-0001-8498-6310
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NR 40
TC 9
Z9 9
U1 3
U2 17
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0024-3205
EI 1879-0631
J9 LIFE SCI
JI Life Sci.
PD NOV 1
PY 2023
VL 332
AR 122116
DI 10.1016/j.lfs.2023.122116
EA SEP 2023
PG 10
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA X5XQ3
UT WOS:001099184000001
PM 37739165
DA 2025-06-11
ER

PT J
AU Choi, SH
   Choi-Kwon, S
AF Choi, Seung-Hye
   Choi-Kwon, Smi
TI The effects of the DASH diet education program with omega-3 fatty acid
   supplementation on metabolic syndrome parameters in elderly women with
   abdominal obesity
SO NUTRITION RESEARCH AND PRACTICE
LA English
DT Article
DE Self efficacy; nutrition; metabolic syndrome; women
ID POLYUNSATURATED FATTY-ACIDS; CARDIOVASCULAR RISK-FACTORS;
   BLOOD-PRESSURE; SELF-EFFICACY; HYPERTENSION; DISEASE; ASSOCIATION;
   ADIPONECTIN; SENSITIVITY; NUTRITION
AB BACKGROUND/OBJECTIVES: The purpose of this study was to investigate the overall effects of a tailored Dietary Approaches to Stop Hypertension (DASH) nutritional intervention program which included omega-3 fatty acids supplementation, on dietary self-efficacy, dietary knowledge, and dietary behaviors in Korean elderly women with abdominal obesity. Furthermore, we investigated the effects of the program on metabolic syndrome parameters including the antioxidant capacities in these subjects.
   SUBJECTS/METHODS: A randomized, controlled trial was conducted for 8 weeks. The experimental group (n = 21) received a weekly tailored nutritional program for 8 weeks and the control group (n = 18) received only one educational session. The clinical survey was conducted before and after the intervention period.
   RESULTS: After the intervention, dietary self-efficacy (P = 0.023), frequency of fruit intake (P = 0.019), and dietary fiber intake (P = 0.044) were higher in the experimental group than in the control group. The oxidative stress (P < 0.001) was lower in the experimental group than in the control group. Moreover, low density lipoprotein (LDL) cholesterol (P = 0.023) had significantly decreased in the experimental group but not in the control group after the intervention.
   CONCLUSIONS: The intervention program including omega-3 fatty acid supplementation had a positive effect on dietary self-efficacy, dietary behaviors, and oxidative stress among aged women with abdominal obesity.
C1 [Choi, Seung-Hye] Suwon Univ, Dept Nursing Sci, Gyeonggi 445743, South Korea.
   [Choi-Kwon, Smi] Seoul Natl Univ, Coll Nursing, 103 Daehak Ro, Seoul 110799, South Korea.
   [Choi-Kwon, Smi] Seoul Natl Univ, Res Inst Nursing Sci, Seoul 110799, South Korea.
C3 Seoul National University (SNU); Seoul National University (SNU)
RP Choi-Kwon, S (corresponding author), Seoul Natl Univ, Coll Nursing, 103 Daehak Ro, Seoul 110799, South Korea.
EM smi@snu.ac.kr
RI Choi, Jah/AAA-4835-2022; Choi, Su-Yeon/C-4312-2013
CR [Anonymous], 2010, DIETARY REFERENCE IN, V1st
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NR 38
TC 12
Z9 13
U1 0
U2 15
PU KOREAN NUTRITION SOC
PI SEOUL
PA 804 KST CTR, 635-4 YEOGSAM-SONG KANGNAM-KU, SEOUL, 135-703, SOUTH KOREA
SN 1976-1457
EI 2005-6168
J9 NUTR RES PRACT
JI Nutr. Res. Pract.
PD APR
PY 2015
VL 9
IS 2
BP 150
EP 157
DI 10.4162/nrp.2015.9.2.150
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA CF6NC
UT WOS:000352672400007
PM 25861421
OA Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Li, BB
   Pang, K
   Hao, L
   Zang, GH
   Wang, J
   Wang, XT
   Zhang, JJ
   Cai, LJ
   Yang, CD
   Han, CH
AF Li, Bi-Bo
   Pang, Kun
   Hao, Lin
   Zang, Guang-Hui
   Wang, Jian
   Wang, Xi-Tao
   Zhang, Jian-Jun
   Cai, Long-Jun
   Yang, Chen-Di
   Han, Cong-Hui
TI Corosolic acid improves erectile function in metabolic syndrome rats by
   reducing reactive oxygen species generation and increasing nitric oxide
   bioavailability
SO FOOD SCIENCE AND TECHNOLOGY
LA English
DT Article
DE corosolic acid; MED; ROS; bioavailability
ID OXIDATIVE STRESS; NADPH OXIDASES; HYPERTENSION
AB To investigate the effect of corosolic acid treatment on erectile function in metabolic syndrome induced rat model. Fifty male 3-week-old SD rats were fed a high fat and high sugar diet. Six months later, metabolic variables were determined. Metabolic syndrome induced erectile function (MED) rats were confirmed by an apomorphine test. Then MED rats were treated with corosolic acid daily by oral gavage for 4 weeks. To evaluate erectile function, intracavernosal pressure (ICP)/mean arterial blood pressure (MAP) ratio was measured. Thiobarbituric acid reactive substances assay and dihydroethidium staining were used to assess reactive oxygen species (ROS) level. Protein expressions of gp91(Phox) and eNOS were examined by western blotting and immunohistochemistry. Fasting blood glucose, body weight, total cholesterol and insulin were markedly increased in metabolic syndrome rats compared with those of the control rats (p < 0.05). The ratios of max ICP/MAP and area under curve (AUC)/MAP was markedly reduced in MED rats compared with the control rats (p < 0.05). The concentration of cyclic guanosine mono-phosphate (cGMP) and the expression of eNOS were significantly decreased in MED rats compared with the control group (p < 0.05). Moreover, ROS level and the expression of gp91(Phox) were significantly increased in MED rats. Treatment with corosolic acid reversed these changes (each p < 0.05). Corosolic acid reduces the level of ROS, ameliorating endothelial dysfunction and improvement of erectile function in MED rats.
C1 [Li, Bi-Bo] Nanjing Univ Chinese Med, Taizhou Affiliated Hosp, Dept Urol, Taizhou, Jiangsu, Peoples R China.
   [Pang, Kun; Hao, Lin; Zang, Guang-Hui; Wang, Jian; Wang, Xi-Tao] Xuzhou Cent Hosp, Dept Urol, Xuzhou, Jiangsu, Peoples R China.
   [Zhang, Jian-Jun; Cai, Long-Jun] Nanjing Drum Tower Hosp Grp, Suqian Peoples Hosp, Dept Urol, Suqian, Jiangsu, Peoples R China.
   [Yang, Chen-Di] Suzhou Hosp Chinese Med, Dept Urol, Suzhou, Jiangsu, Peoples R China.
   [Han, Cong-Hui] Nanjing Univ Chinese Med, Xuzhou Cent Hosp, Dept Urol, Xuzhou, Jiangsu, Peoples R China.
C3 Nanjing University of Chinese Medicine; Nanjing University of Chinese
   Medicine
RP Han, CH (corresponding author), Nanjing Univ Chinese Med, Xuzhou Cent Hosp, Dept Urol, Xuzhou, Jiangsu, Peoples R China.
EM hanch509@hotmail.com
RI YANG, Chendi/LXV-8671-2024
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NR 19
TC 0
Z9 0
U1 2
U2 7
PU SOC BRASILEIRA CIENCIA TECNOLOGIA ALIMENTOS
PI CAMPINAS
PA AV BRASIL 2880, CAXIA POSTAL 271 CEP 13001-970, CAMPINAS, SAO PAULO
   00000, BRAZIL
SN 0101-2061
EI 1678-457X
J9 FOOD SCI TECH-BRAZIL
JI Food Sci. Technol.
PY 2022
VL 42
AR e108821
DI 10.1590/fst.108821
PG 5
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA 0D5RY
UT WOS:000776053700003
OA gold
DA 2025-06-11
ER

PT J
AU Oyovwi, MO
   Ugwuishi, EW
   Udi, OA
   Uchechukwu, GJ
AF Oyovwi, Mega Obukohwo
   Ugwuishi, Emeka Williams
   Udi, Onoriode Andrew
   Uchechukwu, Gregory Joseph
TI Mitophagy Unveiled: Exploring the Nexus of Mitochondrial Health and
   Neuroendocrinopathy
SO JOURNAL OF MOLECULAR NEUROSCIENCE
LA English
DT Article
DE Mitophagy; Mitochondrial health; Neuroendocrinopathy; Oxidative stress;
   Therapeutic interventions; Cellular resilience; Mitochondrial dynamics
ID AMYLOID-BETA TOXICITY; PARKINSONS-DISEASE; ALZHEIMERS-DISEASE;
   NEURODEGENERATIVE DISEASES; OXIDATIVE STRESS; SKELETAL-MUSCLE;
   DYSFUNCTION; MECHANISMS; PROTEIN; SIRT1
AB Mitochondria play a pivotal role in cellular metabolism, energy production, and apoptotic signaling, making mitophagy, the selective degradation of damaged mitochondria, crucial for mitochondrial health. Dysregulation of mitophagy has been implicated in various neuroendocrinopathies, yet the mechanisms linking these processes remain poorly understood. This review aims to explore the intersection between mitophagy and neuroendocrinopathy, addressing the critical gaps in knowledge regarding how mitochondrial dysfunction may contribute to the pathophysiology of neuroendocrine disorders. We conducted a comprehensive literature review of studies published on mitophagy and neuroendocrinopathies, focusing on data that elucidate the pathways involved and the clinical implications of mitochondrial health in neuroendocrine contexts. Our findings indicate that altered mitophagy may lead to the accumulation of dysfunctional mitochondria, contributing to neuroendocrine dysregulation. We present evidence linking impaired mitochondrial clearance to disease models of conditions such as metabolic syndrome, depression, and stress-related disorders, highlighting the potential for therapeutic interventions targeting mitophagy. While significant advances have been made in understanding mitochondrial biology, the direct interplay between mitophagy and neuroendocrinopathies remains underexplored. This review underscores the necessity for further research to elucidate these connections, which may offer novel insights into disease mechanisms and therapeutic strategies for treating maladaptive neuroendocrine responses.
C1 [Oyovwi, Mega Obukohwo] Adeleke Univ, Fac Basic Med Sci, Dept Physiol, Ede, Osun, Nigeria.
   [Ugwuishi, Emeka Williams] Univ Nigeria, Coll Med, Dept Physiol, Enugu, Nigeria.
   [Udi, Onoriode Andrew] Fed Univ Otuoke, Dept Human Anat, Otuoke, Bayelsa, Nigeria.
   [Uchechukwu, Gregory Joseph] Adeleke Univ, Fac Basic Med Sci, Dept Med Lab Sci, Ede, Osun, Nigeria.
C3 University of Nigeria
RP Oyovwi, MO (corresponding author), Adeleke Univ, Fac Basic Med Sci, Dept Physiol, Ede, Osun, Nigeria.
EM megalect@gmail.com
RI Obukohwo, Oyovwi/GRO-1623-2022
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NR 201
TC 1
Z9 1
U1 3
U2 3
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0895-8696
EI 1559-1166
J9 J MOL NEUROSCI
JI J. Mol. Neurosci.
PD NOV 8
PY 2024
VL 74
IS 4
AR 107
DI 10.1007/s12031-024-02280-w
PG 30
WC Biochemistry & Molecular Biology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Neurosciences & Neurology
GA L6E3R
UT WOS:001351625800001
PM 39514132
DA 2025-06-11
ER

PT J
AU Hsu, CH
   Tung, HH
   Clinciu, DL
   Chen, LK
   Yin, WH
   Iqbal, U
   Wang, TJ
AF Hsu, Ching Hwa
   Tung, Heng-Hsin
   Clinciu, Daniel L.
   Chen, Liang-Kung
   Yin, Wei-Hsian
   Iqbal, Usman
   Wang, Tsae-Jyy
TI Physical activity: A primary health quality determinant among
   community-dwelling geriatric women in Taiwan
SO INTERNATIONAL JOURNAL FOR QUALITY IN HEALTH CARE
LA English
DT Article
DE depression; frailty; healthcare quality; geriatric women
ID OLDER-PEOPLE; DEPRESSIVE SYMPTOMS; OF-CARE; FRAILTY; MORTALITY; RISK;
   LIFE; DEFINITION; COUNTRIES; ADULTS
AB Objective: To investigate the associations between frailty, physical activity and depression in community-dwelling geriatric women.
   Design: A cross-sectional research design.
   Setting: Community geriatric women in Illan County, Taiwan.
   Study participants: Of note 216 participants, 65 years and older with full mobility, independent and able to communicate in Mandarin or Taiwanese Hokkien.
   Main Outcome Measures: An average weekly physical activity score International Physical Activity Questionnaire-Short Form (IPAQ-SF) and Taiwan Geriatric Depression Scale. Classification and regression tree (CART) analysis was used to perform decision analysis.
   Results: The average IPAQ-SF score for the 216 participants was 9109.52. When an IPAQ-SF score of 4452 or below was obtained by participants, 38% of them encountered depression-like syndromes, regardless of their frailty status. Diabetes, high risk of metabolic syndrome and lower education were the risk factors found to cause depression among participants with low physical activity levels.
   Conclusions: As women have a longer life expectancy and experience twice the rates of depression of men particularly after menopause, healthcare providers should emphasize exercise and lifestyle changes in order to improve the quality of health in geriatric women.
C1 [Hsu, Ching Hwa; Yin, Wei-Hsian] Cheng Hsin Gen Hosp, Ctr Heart, Div Cardiol, 45 Cheng Hsin St Pei Tou, Taipei 11217, Taiwan.
   [Tung, Heng-Hsin; Wang, Tsae-Jyy] Natl Taipei Univ Nursing & Hlth Sci, 365 Ming Te Rd, Taipei 112, Taiwan.
   [Clinciu, Daniel L.] Natl Chi Nan Univ, Puli, Taiwan.
   [Clinciu, Daniel L.] China Med Univ, Grad Inst Biomed Sci, Taichung, Taiwan.
   [Chen, Liang-Kung] Taipei Vet Gen Hosp, Ctr Geriatr & Gerontol, 201,Sect 2,Shi Pai Rd, Taipei 11217, Taiwan.
   [Iqbal, Usman] Taipei Med Univ, Coll Med Sci & Technol, Taipei, Taiwan.
C3 Cheng Hsin General Hospital; National Taipei University of Nursing &
   Health Science (NTUNHS); National Chi Nan University; China Medical
   University Taiwan; Taipei Veterans General Hospital; Taipei Medical
   University
RP Tung, HH (corresponding author), Natl Taipei Univ Nursing & Hlth Sci, 365 Ming Te Rd, Taipei 112, Taiwan.
EM shannontung719@gmail.com
RI Chen, Liang-Kung/JBI-8802-2023; Iqbal, Usman/L-2467-2016; Clinciu,
   Dan/HTT-4332-2023
OI Hsu, Ching-Hwa/0000-0002-9313-4424; Chen, Liang-Kung/0000-0002-2387-8508
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NR 36
TC 9
Z9 10
U1 2
U2 23
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1353-4505
EI 1464-3677
J9 INT J QUAL HEALTH C
JI Int. J. Qual. Health Care
PD OCT
PY 2017
VL 29
IS 6
BP 792
EP 796
DI 10.1093/intqhc/mzx101
PG 5
WC Health Care Sciences & Services; Health Policy & Services
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services
GA FO5MJ
UT WOS:000416902800006
PM 29024954
OA Bronze
DA 2025-06-11
ER

PT J
AU Vuckovic, M
   Radic, J
   Gelemanovic, A
   Nenadic, DB
   Kolak, E
   Radic, M
AF Vuckovic, Marijana
   Radic, Josipa
   Gelemanovic, Andrea
   Nenadic, Dora Bucan
   Kolak, Ela
   Radic, Mislav
TI Associations between Depression, Nutritional Status and Mediterranean
   Diet in Dalmatian Kidney Transplant Recipients
SO NUTRIENTS
LA English
DT Article
DE depression; nutrition; nutritional status; Mediterranean diet; kidney
   transplant; Dalmatia
ID RENAL-TRANSPLANTATION; METABOLIC SYNDROME; SYMPTOMS; METAANALYSIS;
   OBESITY; WEIGHT
AB Depression has been addressed as a predictor of worse outcomes in kidney transplant recipients (KTRs). Nutritional status plays a great role in treatment of this population. The Mediterranean diet (MeDi) has been associated with lower levels of depressive symptoms. The aim of this cross-sectional study was to determine the rate of depression and its correlations to nutritional status and dietary habits according to the MeDi in Dalmatian KTRs. We included 115 KTRs, and data about body composition and anthropometric, laboratory and clinical parameters were obtained for each study participant. The Beck Depression Inventory-II (BDI-II) questionnaire was used to assess depressive symptoms and the Mediterranean Diet Serving Score (MDSS) was used to assess adherence to the MeDi. We found the presence of depressive symptoms in 21.73% of the Dalmatian KTRs. BDI-II score was reciprocally associated with fat mass, trunk visceral fat, anthropometric parameters of obesity, triglyceride levels and olive oil consumption. Inverse associations were found between BDI-II score and skeletal muscle mass, handgrip strength, MCV, hemoglobin levels and consumption of fish and white meat, as suggested by the MeDi. Our results showed the interconnections between nutritional status, dietary habits and depression in Dalmatian KTRs.
C1 [Vuckovic, Marijana; Radic, Josipa] Univ Hosp Ctr Split, Dept Nephrol & Dialysis, Split 21000, Croatia.
   [Radic, Josipa; Radic, Mislav] Univ Split, Dept Internal Med, Sch Med, Split 21000, Croatia.
   [Gelemanovic, Andrea] Mediterranean Inst Life Sci MedILS, Split 21000, Croatia.
   [Nenadic, Dora Bucan; Kolak, Ela] Univ Hosp Ctr Split, Dept Nutr & Dietet, Split 21000, Croatia.
   [Radic, Mislav] Univ Hosp Ctr Split, Dept Clin Immunol & Rheumatol, Split 21000, Croatia.
C3 University of Split; University of Split; University of Split;
   University of Split
RP Radic, J (corresponding author), Univ Hosp Ctr Split, Dept Nephrol & Dialysis, Split 21000, Croatia.; Radic, J (corresponding author), Univ Split, Dept Internal Med, Sch Med, Split 21000, Croatia.
EM mavuckovic@kbsplit.hr; josiparadic1973@gmail.com; mavuckovic@kbsplit.hr;
   josiparadic1973@gmail.com; andrea.gelemanovic@gmail.com;
   dorabucan@gmail.com
RI Gelemanović, Andrea/AAV-7338-2021; Radic, Josipa/H-3321-2017;
   Gelemanovic, Andrea/F-7218-2017; Radic, Mislav/H-3306-2017
OI Radic, Josipa/0000-0003-2645-7597; Gelemanovic,
   Andrea/0000-0001-9195-646X; Kolak, Ela/0000-0003-2012-9963; Radic,
   Mislav/0000-0003-0350-6800; Bucan Nenadic, Dora/0000-0002-2589-2266
FU project "Digitalization and improvement of nutritional care for patients
   with chronic diseases"
FX FundingThis study is part of the project Digitalization and improvement
   of nutritional care for patients with chronic diseases co-financed by
   the European Regional Development Fund through the Operational Program
   Competitiveness and Cohesion 20142020 KK.01.1.1.04.0115.
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NR 45
TC 6
Z9 6
U1 1
U2 15
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD DEC
PY 2021
VL 13
IS 12
AR 4479
DI 10.3390/nu13124479
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA XX9KX
UT WOS:000736606100001
PM 34960031
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Rameshrad, M
   Razavi, BM
   Imenshahidi, M
   Hosseinzadeh, H
AF Rameshrad, Maryam
   Razavi, Bibi Marjan
   Imenshahidi, Mohsen
   Hosseinzadeh, Hossein
TI Vitis vinifera (grape) seed extract and resveratrol alleviate
   bisphenol-A-induced metabolic syndrome: Biochemical and molecular
   evidences
SO PHYTOTHERAPY RESEARCH
LA English
DT Article
DE bisphenol A; dyslipidemia; grape; hypertension; metabolic syndrome;
   resveratrol
ID OXIDATIVE STRESS; INSULIN-RESISTANCE; ADIPOSE-TISSUE; GREEN TEA;
   MECHANISMS; EXPOSURE; GLUCOSE; ATHEROSCLEROSIS; OBESITY; CROCIN
AB The mechanisms of bisphenol-A (BPA)-induced metabolic syndrome as well as the protective role of grape seed extract (GSE) and resveratrol were investigated. Rats were treated with BPA (0 and 35 mg.kg(-1).day(-1), gavage) plus resveratrol (25, 50, and 100 mg.kg(-1) .day(-1), i.p.) or GSE (3, 6, 12 mg.kg(-1).day(-1), i.p.) or vitamin E (200 IU/kg/every other day, i.p.). After 2 months, mean systolic blood pressure, serum lipid profile, glycaemia, and fat index were examined. By enzyme-linked immunosorbent assay, the serum concentrations of insulin, leptin, adiponectin, and paraoxonase 1, and by real-time polymerase chain reaction as well as western blotting, key liver elements in cholesterol hemostasis (LDLR, CYP7A1, ABCG5 and 8) and insulin signaling (p-Akt/Akt and p-PI3K/PI3K) were measured. BPA increased mean systolic blood pressure, total cholesterol, and low-density lipoprotein cholesterol and reduced paraoxonase1 and the hepatic expression of both ABCG5 and ABCG8. It increased the body fat index, leptin, adiponectin, insulin, and glycaemia level and decreased the hepatic protein expression of p-Akt/Akt and p-PI3K/PI3k. GSE, resveratrol, or vitamin E coadministration along with BPA restored the detrimental effects of BPA in some levels. Herein, the predisposing effects of BPA-induced metabolic syndrome were restored by GSE and resveratrol, linked to the regulation of insulin signaling, ABCG8 expression, and their antioxidant properties.
C1 [Rameshrad, Maryam; Hosseinzadeh, Hossein] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Pharmaceut Res Ctr, Mashhad, Iran.
   [Razavi, Bibi Marjan] Mashhad Univ Med Sci, Sch Pharm, Dept Pharmacodynam & Toxicol, Targeted Drug Delivery Res Ctr, Mashhad, Iran.
   [Razavi, Bibi Marjan; Imenshahidi, Mohsen; Hosseinzadeh, Hossein] Mashhad Univ Med Sci, Sch Pharm, Dept Pharmacodynam & Toxicol, Mashhad, Iran.
C3 Mashhad University of Medical Sciences; Mashhad University of Medical
   Sciences; Mashhad University of Medical Sciences
RP Hosseinzadeh, H (corresponding author), Mashhad Univ Med Sci, Pharmaceut Technol Inst, Pharmaceut Res Ctr, Mashhad, Iran.
EM hosseinzadehh@mums.ac.ir
RI rameshrad, maryam/D-1624-2019; razavi, Bibi Marjan/AAY-5636-2020;
   Hosseinzadeh, Hossein/F-3013-2010
OI rameshrad, maryam/0000-0001-6822-8552; razavi, Bibi
   Marjan/0000-0002-7450-9286; Hosseinzadeh, Hossein/0000-0002-3483-851X
FU Iran National Science Foundation [95004557]; Mashhad University of
   Medical Sciences [941389]
FX Iran National Science Foundation, Grant/Award Numbers: 95004557, NO.
   95004557; Research Vice Chancellors of Mashhad University of Medical
   Sciences, Grant/Award Numbers: 941389, NO. 941389
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NR 65
TC 20
Z9 20
U1 0
U2 17
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0951-418X
EI 1099-1573
J9 PHYTOTHER RES
JI Phytother. Res.
PD MAR
PY 2019
VL 33
IS 3
BP 832
EP 844
DI 10.1002/ptr.6276
PG 13
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA HO6UH
UT WOS:000461067400033
PM 30653759
DA 2025-06-11
ER

PT J
AU Panahi, Y
   Ostadmohammadi, V
   Raygan, F
   Sharif, MR
   Sahebkar, A
AF Panahi, Yunes
   Ostadmohammadi, Vahidreza
   Raygan, Fariba
   Sharif, Mohammad Reza
   Sahebkar, Amirhossein
TI The effects of N-acetylcysteine administration on metabolic status and
   serum adiponectin levels in patients with metabolic syndrome: A
   randomized, double-blind, placebo-controlled trial
SO JOURNAL OF FUNCTIONAL FOODS
LA English
DT Article
DE N-acetylcysteine; Metabolic status; Metabolic syndrome; Oxidative
   stress; Inflammation
ID ACETYL-L-CYSTEINE; OXIDATIVE STRESS; INFLAMMATORY RESPONSE; INSULIN
   SENSITIVITY; METFORMIN; WOMEN; SUPPLEMENTATION; MALONDIALDEHYDE;
   GLUTATHIONE; ACTIVATION
AB Objective: This study examined the impact of N-acetylcysteine (NAC) administration on metabolic parameters and serum adiponectin levels in individuals with metabolic syndrome (MetS).Methods: This randomized clinical trial included 76 people with MetS, aged 25-75 years. Participants were randomly assigned to receive either 1800 mg/day NAC (n = 38) or matched placebo (n = 38) for 12 weeks. Fasting blood samples were collected at the onset and at the end of 12-week intervention to quantify metabolic parameters. Results: NAC significantly reduced fasting plasma glucose (P = 0.02), fasting serum insulin (P = 0.006), insulin resistance index (P = 0.005), and serum C-reactive protein (P = 0.003), and increased serum HDL-cholesterol (P = 0.001) and plasma total glutathione (P < 0.001) versus the placebo group. NAC administration did not alter adiponectin, blood pressure, other lipid indices, malondialdehyde, and total antioxidant capacity. Conclusions: Overall, 1800 mg/day NAC consumption for 12 weeks in MetS subjects had positive impacts on the parameters of glycemic homeostasis, HDL-cholesterol, inflammatory status, and body antioxidative defense system. NAC prescription may be a new strategy for the amelioration of metabolic parameters in individuals with MetS.Clinical Trial Registration: This clinical trial was prospectively registered in the Iranian website for registration of clinical trials (https://www.irct.ir/trial/44284).
C1 [Panahi, Yunes] Baqiyatallah Univ Med Sci, Sch Pharm, Pharmacotherapy Dept, Tehran, Iran.
   [Ostadmohammadi, Vahidreza; Raygan, Fariba] Kashan Univ Med Sci, Fac Med, Dept Internal Med, Kashan, Iran.
   [Ostadmohammadi, Vahidreza; Sharif, Mohammad Reza] Kashan Univ Med Sci, Infect Dis Res Ctr, Kashan, Iran.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Appl Biomed Res Ctr, Mashhad, Iran.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Biotechnol Res Ctr, Mashhad, Iran.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Sch Pharm, Dept Biotechnol, Mashhad, Iran.
C3 Baqiyatallah University of Medical Sciences (BMSU); Mashhad University
   of Medical Sciences; Mashhad University of Medical Sciences; Mashhad
   University of Medical Sciences
RP Panahi, Y (corresponding author), Baqiyatallah Univ Med Sci, Sch Pharm, Pharmacotherapy Dept, Tehran, Iran.; Ostadmohammadi, V (corresponding author), Kashan Univ Med Sci, Fac Med, Dept Internal Med, Kashan, Iran.; Sahebkar, A (corresponding author), Mashhad Univ Med Sci, Appl Biomed Res Ctr, Mashhad, Iran.
EM yunespanahi@yahoo.com; vrom.1993@gmail.com; amir_saheb2000@yahoo.com
RI Raygan, Fariba/W-3349-2017; Sahebkar, Amirhossein/B-5124-2018;
   Ostadmohammadi, Vahidreza/A-6248-2018; Sharif, Mohammad
   Reza/GWQ-8947-2022
OI Ostadmohammadi, Vahidreza/0000-0002-4633-5397; Sharif, Mohammad
   Reza/0000-0002-2049-3370
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NR 56
TC 7
Z9 7
U1 0
U2 13
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1756-4646
EI 2214-9414
J9 J FUNCT FOODS
JI J. Funct. Food.
PD DEC
PY 2022
VL 99
AR 105299
DI 10.1016/j.jff.2022.105299
EA OCT 2022
PG 6
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA 6Q8DC
UT WOS:000891839200002
OA gold
DA 2025-06-11
ER

PT J
AU Kang, HT
   Linton, JA
   Shim, JY
AF Kang, Hee-Taik
   Linton, John A.
   Shim, Jae-Yong
TI Serum ferritin level is associated with the prevalence of metabolic
   syndrome in Korean adults: The 2007-2008 Korean National Health and
   Nutrition Examination Survey
SO CLINICA CHIMICA ACTA
LA English
DT Article
DE Ferritin; Insulin resistance; Inflammation; Oxidative stress; Metabolic
   syndrome
ID CARDIOVASCULAR RISK-FACTORS; C-REACTIVE PROTEIN; INSULIN-RESISTANCE;
   OXIDATIVE STRESS; PLASMA-MEMBRANE; IRON STORES; DISEASE; MEN;
   INFLAMMATION; OBESITY
AB Background: Increased ferritin concentrations, which reflect body iron stores, contribute to insulin dysfunction and metabolic syndrome (MetS).
   Methods: This cross-sectional study included 7346 subjects (3229 men and 4117 women) who participated in the 2007-2008 Korean National Health and Nutrition Examination Survey (KNHANES). We adopted the modified Asian criteria for MetS from the American Heart Association/National Heart, Lung, and Blood Institute.
   Results: In comparison with participants in the first serum ferritin quartile, the odds ratio (95% confidence interval) for MetS for participants in the fourth serum ferritin quartile was 1.67 (1.24-2.23) in men and 1.41 (1.06-1.88) in women after adjusting for multiple covariates (including menopausal status in women) except insulin resistance. This association was attenuated, however, after additionally adjusting for insulin resistance (1.46 (1.08-1.98) in men and 1.22 (0.91-1.65) in women]. In particular, higher serum ferritin concentrations were associated with increased triglyceride concentrations in men and glucose intolerance in women.
   Conclusions: Increased serum ferritin level was positively associated with the prevalence of MetS and with some diagnostic components of MetS, i.e., we found that increased serum ferritin concentrations were associated with high triglyceride and glucose concentrations in men and women, respectively. (C) 2011 Elsevier B.V. All rights reserved.
C1 [Kang, Hee-Taik; Shim, Jae-Yong] Yonsei Univ, Coll Med, Dept Family Med, Gangnam Severance Hosp, Seoul, South Korea.
   [Kang, Hee-Taik] Yonsei Univ, Dept Med, Grad Sch, Seoul 120749, South Korea.
   [Linton, John A.] Yonsei Univ, Coll Med, Severance Hosp, Int Hlth Care Ctr, Seoul, South Korea.
C3 Yonsei University; Yonsei University Health System; Yonsei University;
   Yonsei University; Yonsei University Health System
RP Shim, JY (corresponding author), Yonsei Univ, Coll Med, Dept Family Med, 712 Eonju Ro, Seoul, South Korea.
EM hope@yuhs.ac
RI Shim, Jae Yong/GLU-2862-2022
OI Kang, Hee-Taik/0000-0001-8048-6247; Shim, JaeYong/0000-0002-9561-9230;
   Linton, John/0000-0001-8000-3049
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NR 28
TC 40
Z9 42
U1 0
U2 4
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0009-8981
J9 CLIN CHIM ACTA
JI Clin. Chim. Acta
PD MAR 22
PY 2012
VL 413
IS 5-6
BP 636
EP 641
DI 10.1016/j.cca.2011.12.011
PG 6
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA 961UW
UT WOS:000305496000020
PM 22212623
DA 2025-06-11
ER

PT J
AU Sebeková, K
   Boor, P
   Valachovicová, M
   Blazícek, P
   Parrák, V
   Babinská, K
   Heidland, A
   Krajcovicová-Kudlácková, M
AF Sebekova, Katarina
   Boor, Peter
   Valachovicova, Martina
   Blazicek, Pavol
   Parrak, Vojtech
   Babinska, Katarina
   Heidland, August
   Krajcovicova-Kudlackova, Marica
TI Association of metabolic syndrome risk factors with selected markers of
   oxidative status and microinflammation in healthy omnivores and
   vegetarians
SO MOLECULAR NUTRITION & FOOD RESEARCH
LA English
DT Article
DE advanced glycation end products; advanced oxidation protein products;
   inflammation; metabolic syndrome risk factors; oxidative status
ID C-REACTIVE PROTEIN; GLYCATION END-PRODUCTS; INSULIN SENSITIVITY;
   BETA-CAROTENE; VITAMIN-E; EXERCISE INTERVENTION; KAPPA-B; ANTIOXIDANT;
   STRESS; PLASMA
AB Conditions predisposing to metabolic syndrome (MetS) are associated with increased oxidative stress and inflammation. We studied, in vegetarians (n = 90) and omnivores (n = 46), the impact of the dietary regimen on the occurrence of MetS risk factors (RFs: BMI, blood pressure, glucose metabolism and lipid profile) in relation to oxidative status (advanced glycation end products (AGEs), advanced oxidation protein products (AOPPs), malondialdehyde, ferric reducing ability of plasma, vitamins A, E, C, beta-carotene and superoxide dismutase activity) and microinflammation (C-reactive protein, leukocytes and neopterin). The proportion of subjects without/positive for one or two MetS RFs was comparable between the groups. From the components of MetS only immunoreactive insulin levels differed significantly (95% Cl: omnivores: 5.0-7.1 mu U/mL, vegetarians: 4.5-5.4,p = 0.03). Omnivores had lower AOPP (omnivores: 0.29-0.36 mu mol/g albumin, vegetarians: 0.36-0.52, p = 0.01) and beta-carotene levels than vegetarians, they consumed more calories, proteins, fat and saturated fatty acids, and less fibres, beta-carotene and vitamin C. Multiple regression analysis revealed vitamin E and AOPP levels as the most important independent determinants of MetS RFs. The vegetarian diet seems to exert beneficial effects on MetS RFs associated microinflammation. Whether the vegetarian diet may counteract the deleterious effects of elevated AOPPs and AGEs, remains to be elucidated.
C1 Slovak Med Univ, Dept Clin & Expt Pharmacotherapy, Res Base, Bratislava 83303, Slovakia.
   Hosp Minist Def Slovak Republ, Bratislava, Slovakia.
   Hosp Univ Petrzalka, Bratislava, Slovakia.
   Comenius Univ, Fac Med, Bratislava, Slovakia.
   Univ Wurzburg, Wurzburg, Germany.
C3 Slovak Medical University Bratislava; Comenius University Bratislava;
   University of Wurzburg
RP Sebeková, K (corresponding author), Slovak Med Univ, Dept Clin & Expt Pharmacotherapy, Res Base, Limbova 12, Bratislava 83303, Slovakia.
EM katarina.sebekova@szu.sk
RI Babinská, Katarína/AAC-9817-2019; Valachovicova, Martina/AAS-1791-2020;
   Sebekova, Katarina/H-4906-2016; Boor, Peter/C-7707-2011
OI Babinska, Katarina/0000-0002-0385-025X; Valachovicova,
   Martina/0000-0003-3110-6417; Sebekova, Katarina/0000-0002-9641-9265;
   Boor, Peter/0000-0001-9921-4284
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NR 39
TC 52
Z9 58
U1 0
U2 10
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1613-4125
EI 1613-4133
J9 MOL NUTR FOOD RES
JI Mol. Nutr. Food Res.
PD SEP
PY 2006
VL 50
IS 9
BP 858
EP 868
DI 10.1002/mnfr.200500170
PG 11
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA 086SG
UT WOS:000240692700011
PM 16917805
DA 2025-06-11
ER

PT J
AU Trinei, M
   Berniakovich, I
   Beltrami, E
   Migliaccio, E
   Fassina, A
   Pelicci, P
   Giorgio, M
AF Trinei, Mirella
   Berniakovich, Ina
   Beltrami, Elena
   Migliaccio, Enrica
   Fassina, Ambrogio
   Pelicci, PierGiuseppe
   Giorgio, Marco
TI P66Shc signals to age
SO AGING-US
LA English
DT Review
DE aging; life span; degenerative disease; oxidative stress
ID VASCULAR OXIDATIVE STRESS; CORONARY-HEART-DISEASE; FREE-RADICAL THEORY;
   HIGH-FAT DIET; METABOLIC SYNDROME; INSULIN-RESISTANCE;
   CARDIOVASCULAR-DISEASE; ADAPTER PROTEIN; LIFE-SPAN; ENDOTHELIAL
   DYSFUNCTION
AB Oxygen metabolism is thought to impact on aging through the formation of reactive oxygen species (ROS) that are supposed to damage biological molecules. The study of p66Shc, a crucial regulator of ROS level involved in aging dysfunction, suggests that the incidence of degenerative disease and longevity are determined by a specific signaling function of ROS other than their unspecific damaging property.
C1 [Berniakovich, Ina; Beltrami, Elena; Migliaccio, Enrica; Pelicci, PierGiuseppe; Giorgio, Marco] European Inst Oncol, Dept Expt Oncol, I-20139 Milan, Italy.
   [Trinei, Mirella] Congenia Srl, I-20139 Milan, Italy.
   [Fassina, Ambrogio] Cytophatol Unit, Pathol Sect, Dept Oncol & Surg Sci, I-35100 Padua, Italy.
C3 IRCCS European Institute of Oncology (IEO); IRCCS Istituto Oncologico
   Veneto (IOV)
RP Giorgio, M (corresponding author), European Inst Oncol, Dept Expt Oncol, Via Adamello 16, I-20139 Milan, Italy.
EM Marco.giorgio@ifom-ieo-campus.it
RI Pelicci, Pier/AAL-6572-2020; beltrami, elena/AAE-9937-2021; Migliaccio,
   Enrica/AAQ-8880-2020; Giorgio, Marco/I-9425-2012
OI , Enrica Migliaccio/0000-0002-3989-8773; PELICCI, PIER
   GIUSEPPE/0000-0002-5076-2316
FU National Institute of Health [1P01AG025532-01A1]
FX We thank Paola Dalton for the preparation of the manuscript. This work
   was supported by National Institute of Health Grant 1P01AG025532-01A1.
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NR 48
TC 73
Z9 77
U1 0
U2 3
PU IMPACT JOURNALS LLC
PI ORCHARD PARK
PA 6666 E QUAKER ST, STE 1, ORCHARD PARK, NY 14127 USA
SN 1945-4589
J9 AGING-US
JI Aging-US
PD JUN
PY 2009
VL 1
IS 6
BP 503
EP 510
DI 10.18632/aging.100057
PG 8
WC Cell Biology; Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Geriatrics & Gerontology
GA 579UP
UT WOS:000276401300001
PM 20157533
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Bhaswant, M
   Fanning, K
   Netzel, M
   Mathai, ML
   Panchal, SK
   Brown, L
AF Bhaswant, Maharshi
   Fanning, Kent
   Netzel, Michael
   Mathai, Michael L.
   Panchal, Sunil K.
   Brown, Lindsay
TI Cyanidin 3-glucoside improves diet-induced metabolic syndrome in rats
SO PHARMACOLOGICAL RESEARCH
LA English
DT Article
DE Metabolic syndrome; Anthocyanins; Cyanidin 3-glucoside; Queen Garnet
   plum; Obesity; Inflammation
ID HIGH-CARBOHYDRATE; PROTOCATECHUIC ACID; OXIDATIVE STRESS; GUT
   MICROBIOTA; BLOOD-PRESSURE; ANTHOCYANINS; JUICE; OBESITY; RICH;
   CONSUMPTION
AB Increased consumption of dark-coloured fruits and vegetables may mitigate metabolic syndrome. This study has determined the changes in metabolic parameters, and in cardiovascular and liver structure and function, following chronic administration of either cyanidin 3-glucoside (CG) or Queen Garnet plum juice (QG) containing cyanidin glycosides to rats fed either a corn starch (C) or a high-carbohydrate, high-fat (H) diet. Eight to nine-week-old male Wistar rats were randomly divided into six groups for 16-week feeding with C, C with CG or QG, H or H with CG or QG. C or H were supplemented with CG or QG at a dose of similar to 8 mg/kg/day cyanidin glycosides from week 8 to 16. H rats developed signs of metabolic syndrome including visceral adiposity, impaired glucose tolerance, hypertension, cardiovascular remodelling, increased collagen deposition in left ventricle, non-alcoholic fatty liver disease, increased plasma liver enzymes and increased inflammatory cell infiltration in the heart and liver. Both CG and QG reversed these cardiovascular, liver and metabolic signs. However, no intact anthocyanins or common methylated/conjugated metabolites could be detected in the plasma samples and plasma hippuric acid concentrations were unchanged. Our results suggest CG is the most likely mediator of the responses to QG but that further investigation of the pharmacokinetics of oral CG in rats is required. (C) 2015 Elsevier Ltd. All rights reserved.
C1 [Bhaswant, Maharshi; Mathai, Michael L.] Victoria Univ, Coll Hlth & Biomed, Ctr Chron Dis Prevent & Management, Melbourne, Vic 8001, Australia.
   [Bhaswant, Maharshi; Brown, Lindsay] Univ So Queensland, Sch Hlth & Wellbeing, Toowoomba, Qld 4350, Australia.
   [Fanning, Kent] Dept Agr & Fisheries, Coopers Plains, Qld, Australia.
   [Netzel, Michael] Univ Queensland, Queensland Alliance Agr & Food Innovat, Ctr Nutr & Food Sci, Brisbane, Qld, Australia.
   [Panchal, Sunil K.; Brown, Lindsay] Univ So Queensland, Inst Agr & Environm, Toowoomba, Qld 4350, Australia.
C3 Victoria University; University of Southern Queensland; University of
   Queensland; University of Southern Queensland
RP Brown, L (corresponding author), Univ So Queensland, Sch Hlth & Wellbeing, Toowoomba, Qld 4350, Australia.
EM Lindsay.Brown@usq.edu.au
RI Netzel, Michael/M-4050-2013; Bhaswant, Maharshi/G-3676-2017
OI Panchal, Sunil K/0000-0001-5464-3376; , Maharshi
   Bhaswant/0000-0003-4501-5487; Mathai, Michael/0000-0001-8783-2122;
   Netzel, Michael/0000-0002-3136-3926
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NR 54
TC 52
Z9 56
U1 0
U2 49
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 1043-6618
J9 PHARMACOL RES
JI Pharmacol. Res.
PD DEC
PY 2015
VL 102
BP 208
EP 217
DI 10.1016/j.phrs.2015.10.006
PG 10
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA CZ0KG
UT WOS:000366793100024
PM 26477387
DA 2025-06-11
ER

PT J
AU Zuberi, AR
AF Zuberi, Aamir R.
TI Strategies for assessment of botanical action on metabolic syndrome in
   the mouse and evidence for a genotype-specific effect of Russian
   tarragon in the regulation of insulin sensitivity
SO METABOLISM-CLINICAL AND EXPERIMENTAL
LA English
DT Article
ID TASTE-AVERSION; AGOUTI PROTEIN; MODIFIER GENES; MICE; OBESITY; DIET;
   HUMANS; DETERMINANTS; RESISTANCE; ADIPOSITY
AB Published reports of botanical action are often hampered by the lack of generalized systematic approaches or by the failure to explore mechanisms that could confirm and extend the reported observations. Choice of mouse or rat housing conditions (singly or group housed) and imposed stress during handling procedures are often variable and can contribute significantly to differences in baseline phenotypes measured across studies. Differences can also be observed in the role of the extract in either the treatment of the metabolic syndrome or roles in the regulation of the emergence of metabolic syndrome. The choice of diet used can also vary between the different studies, and diet-botanical interactions must be considered. This minireview highlights the strategies being pursued by the Botanical Research Center Animal Research Core to evaluate the in vivo phenotypes of several botanical extracts during long-term feeding studies. We describe a phenotyping strategy that promotes a more rigorous interpretation of botanical action and can suggest or eliminate possible mechanisms that may be involved. We discuss the importance of selecting the mouse model, as background strain can significantly alter the underlying susceptibilities to the various components of metabolic syndrome. Finally, we present data suggesting that one of the major botanical extracts being studied, an extract of Russian tarragon, may manifest a mouse strain genotype-specific insulin-sensitizing phenotype. (C) 2008 Elsevier Inc. All rights reserved.
C1 Louisiana State Univ Syst, Pennington Biomed Res Ctr, Baton Rouge, LA 70810 USA.
C3 Louisiana State University System; Louisiana State University;
   Pennington Biomedical Research Center
RP Zuberi, AR (corresponding author), Louisiana State Univ Syst, Pennington Biomed Res Ctr, Baton Rouge, LA 70810 USA.
EM zuberia@pbrc.edu
FU NCCIH NIH HHS [P50AT002776-01, 5P50AT002776-039001, P50 AT002776]
   Funding Source: Medline; NIDDK NIH HHS [R01 DK064071, DK064071] Funding
   Source: Medline
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NR 28
TC 13
Z9 14
U1 0
U2 0
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0026-0495
J9 METABOLISM
JI Metab.-Clin. Exp.
PD JUL
PY 2008
VL 57
IS 7
SU 1
BP S10
EP S15
DI 10.1016/j.metabol.2008.03.002
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 323EM
UT WOS:000257426800004
PM 18555848
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Lissoni, P
   Rovelli, F
   Monzon, A
   Messina, G
   Merli, N
   Tartarelli, R
   Tassoni, S
   Zecchinato, F
   Simoes-e-Silva, AC
   Valentini, A
   Di Fede, G
   Cardinali, DP
AF Lissoni, Paolo
   Rovelli, Franco
   Monzon, Alejandra
   Messina, Giusy
   Merli, Nicoletta
   Tartarelli, Rosanna
   Tassoni, Simonetta
   Zecchinato, Francesca
   Simoes-e-Silva, Ana Cristina
   Valentini, Agnese
   Di Fede, Giuseppe
   Cardinali, Daniel P.
TI Efficacy of a Neuroimmune Therapy Including Pineal Methoxyindoles,
   Angiotensin 1-7, and Endocannabinoids in Cancer, Autoimmune, and
   Neurodegenerative Diseases
SO CLINICAL INTERVENTIONS IN AGING
LA English
DT Article
DE melatonin; 5-methoxytryptamine; metainflammation; noncommunicable
   diseases; oxytocin; pinoline
ID PSYCHOACTIVE COMPOUNDS; METABOLIC SYNDROME; BETA-CARBOLINES; MAMMALIAN
   BODY; RECEPTOR AXIS; SYSTEM; CELLS; INFLAMMATION; COMPONENTS; INHIBITORS
AB Purpose: Recent advancements in psycho-neuro-endocrine-immunology indicate that numerous noncommunicable diseases (NCDs) originate from disruptions in the cytokine immune network, resulting in chronic inflammatory responses. This persistent low-degree inflammation is attributed to deficiencies in crucial endogenous anti-inflammatory neuroendocrine systems, including the pineal gland, the endocannabinoid system, and the angiotensin-converting enzyme 2 / angiotensin 1-7 axis. The administration of pineal methoxyindoles (melatonin, 5-methoxytryptamine), cannabinoids, and angiotensin 1-7 may entail potential therapeutic benefits for NCDs, particularly for patients who do not respond to conventional treatments. Patients and Methods: This study evaluates the safety and efficacy of a neuroimmune regimen comprising melatonin (100 mg/day at night), 5-methoxytryptamine (30 mg in the early afternoon), angiotensin 1-7 (0.5 mg twice daily), and cannabidiol (20 mg twice daily) in 306 patients with NCDs, including advanced cancer, autoimmune diseases, neurodegenerative disorders, depression, and cardiovascular disease. Results: The neuroimmune regimen successfully halted cancer progression in 68% of cancer patients, who also reported improvements in mood, sleep, and relief from anxiety, pain, and fatigue. In patients with autoimmune diseases, the treatment effectively controlled the disease process, remarkable in cases of multiple sclerosis. Additionally, positive outcomes were observed in patients with Parkinson's disease, Alzheimer's disease, and depression. Conclusion: Randomized controlled trials are required to assess this therapeutic approach for NCDs that includes endogenous neuroendocrine molecules regulating immune responses in an anti-inflammatory manner.
C1 [Lissoni, Paolo; Rovelli, Franco; Monzon, Alejandra; Messina, Giusy; Merli, Nicoletta; Di Fede, Giuseppe] Int Inst PNEI, Inst Biol Med, Milan, Italy.
   [Tartarelli, Rosanna; Tassoni, Simonetta] PNEI Psychol Serv, Pietrasanta, Lucca, Italy.
   [Zecchinato, Francesca] Biotherapy Serv, Verona, Italy.
   [Simoes-e-Silva, Ana Cristina] Fac Med, Belo Horizonte, Brazil.
   [Valentini, Agnese] Madonna Soccorso Hosp, San Benedetto Tronto, Ascoli Piceno, Italy.
   [Cardinali, Daniel P.] Pontificia Univ Catolica Argentina, Fac Ciencias Med, Av Moreau de Justo 1300,C1107AFA, Buenos Aires, Argentina.
C3 Pontificia Universidad Catolica Argentina
RP Cardinali, DP (corresponding author), Pontificia Univ Catolica Argentina, Fac Ciencias Med, Av Moreau de Justo 1300,C1107AFA, Buenos Aires, Argentina.
EM cardinalidanielpedro@gmail.com
RI Di Fede, Giuseppe/K-1394-2016; Mota, Ana/JBS-4609-2023; Simoes e Silva,
   Ana Cristina/A-4409-2013
OI Simoes e Silva, Ana Cristina/0000-0001-9222-3882
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NR 75
TC 0
Z9 0
U1 0
U2 0
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
EI 1178-1998
J9 CLIN INTERV AGING
JI Clin. Interv. Aging
PY 2025
VL 20
BP 513
EP 522
DI 10.2147/CIA.S513910
PG 10
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA 2ED6U
UT WOS:001480502400001
PM 40330271
DA 2025-06-11
ER

PT J
AU Vincent, AM
   Hinder, LM
   Pop-Busui, R
   Feldman, EL
AF Vincent, Andrea M.
   Hinder, Lucy M.
   Pop-Busui, Rodica
   Feldman, Eva L.
TI Hyperlipidemia: a new therapeutic target for diabetic neuropathy
SO JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM
LA English
DT Review
DE low-density lipoprotein; mitochondria; NAD(P)H oxidase; oxLDL;
   triglycerides
ID LOW-DENSITY-LIPOPROTEIN; PROGRAMMED CELL-DEATH; INDUCED OXIDATIVE
   STRESS; HUMAN ENDOTHELIAL-CELLS; OXIDIZED LDL; METABOLIC SYNDROME;
   VASCULAR COMPLICATIONS; NEUROVASCULAR FUNCTION; PERIPHERAL NEUROPATHY;
   LOX-1 EXPRESSION
AB Emerging data establish dyslipidemia as a significant contributor to the development of diabetic neuropathy. In this review, we discuss how separate metabolic imbalances, including hyperglycemia and hyperlipidemia, converge on mechanisms leading to oxidative stress in dorsal root ganglia (DRG) sensory neurons. We conclude with suggestions for novel therapeutic strategies to prevent or reverse diabetes-induced nerve degeneration.
C1 [Vincent, Andrea M.; Hinder, Lucy M.; Feldman, Eva L.] Univ Michigan, Dept Neurol, Ann Arbor, MI 48109 USA.
   [Pop-Busui, Rodica] Univ Michigan, Dept Internal Med, Ann Arbor, MI 48109 USA.
C3 University of Michigan System; University of Michigan; University of
   Michigan System; University of Michigan
RP Vincent, AM (corresponding author), Univ Michigan, Dept Neurol, 5017 BSRB,109 Zina Pitcher Pl, Ann Arbor, MI 48109 USA.
EM andreav@umich.edu
OI Pop-Busui, Rodica/0000-0002-2042-1350; Hinder, Lucy/0000-0002-5206-8010;
   Feldman, Eva/0000-0002-9162-2694
FU Juvenile Diabetes Research Foundation; American Diabetes Association;
   Animal Models of Diabetes Complications Consortium [UO1 DK076160];
   Program for Neurology Research and Discovery; A. Alfred Taubman Medical
   Institute
FX The Feldman Laboratory is supported by the Juvenile Diabetes Research
   Foundation (A. M. V., E. L. F., R. P. B.), the American Diabetes
   Association (A. M. V., E. L. F., R. P. B.), the Animal Models of
   Diabetes Complications Consortium (NIH UO1 DK076160, E. L. F.), the
   Program for Neurology Research and Discovery, and the A. Alfred Taubman
   Medical Institute.
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NR 113
TC 125
Z9 134
U1 3
U2 19
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1085-9489
EI 1529-8027
J9 J PERIPHER NERV SYST
JI J. Peripher. Nerv. Syst.
PD DEC
PY 2009
VL 14
IS 4
BP 257
EP 267
DI 10.1111/j.1529-8027.2009.00237.x
PG 11
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 533ZT
UT WOS:000272865900001
PM 20021567
OA Green Published, Bronze, Green Accepted
DA 2025-06-11
ER

PT J
AU Castillo-García, EL
   Cossio-Ramírez, AL
   Córdoba-Méndez, OA
   Loza-Mejía, MA
   Salazar, JR
   Chávez-Gutiérrez, E
   Bautista-Poblet, G
   Castillo-Mendieta, NT
   Moreno, DA
   García-Viguera, C
   Pinto-Almazán, R
   Almanza-Pérez, JC
   Gallardo, JM
   Guerra-Araiza, C
AF Castillo-Garcia, Emily Leonela
   Cossio-Ramirez, Ana Lizzet
   Cordoba-Mendez, Oscar Arturo
   Loza-Mejia, Marco A.
   Salazar, Juan Rodrigo
   Chavez-Gutierrez, Edwin
   Bautista-Poblet, Guadalupe
   Castillo-Mendieta, Nadia Tzayaka
   Moreno, Diego A.
   Garcia-Viguera, Cristina
   Pinto-Almazan, Rodolfo
   Almanza-Perez, Julio Cesar
   Gallardo, Juan Manuel
   Guerra-Araiza, Christian
TI In Silico and In Vivo Evaluation of the Maqui Berry (Aristotelia
   chilensis (Mol.) Stuntz) on Biochemical Parameters and Oxidative
   Stress Markers in a Metabolic Syndrome Model
SO METABOLITES
LA English
DT Article
DE metabolic syndrome; maqui berry; molecular docking; diet-induced model;
   oxidative stress
ID MOLECULAR DOCKING; ANTHOCYANINS; LIGAND; SIMULATIONS; CYANIDIN; BINDING;
   VITRO; RICH
AB Metabolic syndrome (MetS) is a complex disease that includes metabolic and physiological alterations in various organs such as the heart, pancreas, liver, and brain. Reports indicate that blackberry consumption, such as maqui berry, has a beneficial effect on chronic diseases such as cardiovascular disease, obesity, and diabetes. In the present study, in vivo and in silico studies have been performed to evaluate the molecular mechanisms implied to improve the metabolic parameters of MetS. Fourteen-day administration of maqui berry reduces weight gain, blood fasting glucose, total blood cholesterol, triacylglycerides, insulin resistance, and blood pressure impairment in the diet-induced MetS model in male and female rats. In addition, in the serum of male and female rats, the administration of maqui berry (MB) improved the concentration of MDA, the activity of SOD, and the formation of carbonyls in the group subjected to the diet-induced MetS model. In silico studies revealed that delphinidin and its glycosylated derivatives could be ligands of some metabolic targets such as alpha-glucosidase, PPAR-alpha, and PPAR-gamma, which are related to MetS parameters. The experimental results obtained in the study suggest that even at low systemic concentrations, anthocyanin glycosides and aglycones could simultaneously act on different targets related to MetS. Therefore, these molecules could be used as coadjuvants in pharmacological interventions or as templates for designing new multitarget molecules to manage patients with MetS.
C1 [Castillo-Garcia, Emily Leonela; Bautista-Poblet, Guadalupe; Guerra-Araiza, Christian] Hosp Especialidades Dr Bernardo Sepulveda, Ctr Med Nacl Siglo 21, Inst Mexicano Seguro Social, Unidad Invest Med Farmacol, Mexico City 06720, Mexico.
   [Castillo-Garcia, Emily Leonela; Bautista-Poblet, Guadalupe] Univ Autonoma Metropolitana, Doctorado Ciencias Biol & Salud, Mexico City 52919, Mexico.
   [Cossio-Ramirez, Ana Lizzet] Escuela Super Med, Inst Politecn Nacl, Secc Estudios Posgrad & Invest, Maestria Ciencias Salud, Mexico City 11340, Mexico.
   [Cordoba-Mendez, Oscar Arturo; Loza-Mejia, Marco A.; Salazar, Juan Rodrigo] Univ La Salle Mexico, Chem Sci Sch, Design Isolat & Synth Bioact Mol Res Grp, Benjamin Franklin 45, Mexico City 06140, Mexico.
   [Chavez-Gutierrez, Edwin] Escuela Nacl Ciencias Biol, Inst Politecn Nacl, Doctorado Ciencias Biomed & Biotecnol Mol, Prolongacion Manuel Carpio & Plan Ayala S-N, Mexico City 11340, Mexico.
   [Castillo-Mendieta, Nadia Tzayaka] Hosp Especialidades Ctr Med La Raza, Inst Mexicano Seguro Social, Ctr Med Nacl Siglo 21, Postdoctorate Conacyt Unidad Invest Med Enfermedad, Av Cuauhtemoc 330 Col Doctores, Mexico City 06725, Mexico.
   [Moreno, Diego A.; Garcia-Viguera, Cristina] CSIC, Lab Fitoquim & Alimentos Saludables LabFAS, CEBAS, Campus Univ Espinardo 25, E-30100 Murcia, Spain.
   [Pinto-Almazan, Rodolfo] Escuela Super Med, Inst Politecn Nacl, Secc Estudios Posgrad & Invest, Mexico City 11340, Mexico.
   [Almanza-Perez, Julio Cesar] UAM I, Dept Ciencias Salud, Lab Farmacol, DCBS, Mexico City 09310, Mexico.
   [Gallardo, Juan Manuel] Hosp Especialidades Ctr Med La Raza, Ctr Med Nacl Siglo 21, Unidad Invest Med Enfermedades Nefrol, Inst Mexicano Seguro Social, Mexico City 06720, Mexico.
C3 Instituto Mexicano del Seguro Social; Universidad Autonoma Metropolitana
   - Mexico; Instituto Politecnico Nacional - Mexico; Instituto Politecnico
   Nacional - Mexico; Instituto Mexicano del Seguro Social; Consejo
   Superior de Investigaciones Cientificas (CSIC); CSIC - Centro de
   Edafologia y Biologia Aplicada del Segura (CEBAS); Instituto Politecnico
   Nacional - Mexico; Universidad Autonoma Metropolitana - Mexico;
   Instituto Mexicano del Seguro Social
RP Guerra-Araiza, C (corresponding author), Hosp Especialidades Dr Bernardo Sepulveda, Ctr Med Nacl Siglo 21, Inst Mexicano Seguro Social, Unidad Invest Med Farmacol, Mexico City 06720, Mexico.; Pinto-Almazán, R (corresponding author), Escuela Super Med, Inst Politecn Nacl, Secc Estudios Posgrad & Invest, Mexico City 11340, Mexico.
EM cbs2202800924@tlitani.uam.mx; acossior2100@alumno.ipn.mx;
   oc@lasallistas.org.mx; marcoantonio.loza@lasalle.mx;
   juan.salazar@lasalle.mx; echavezg1700@alumno.ipn.mx;
   cbs2221801021@xanum.uam.mx; tzayakita@gmail.com; dmoreno@cebas.csic.es;
   cgviguera@cebas.csic.es; rodolfopintoalmazan@gmail.com;
   jcap@xanum.uam.mx; jmgallardom@gmail.com; christianguerra2001@gmail.com
RI Chávez Gutiérrez, Edwin/KCY-3394-2024; GALLARDO, Juan/HGF-1360-2022;
   Salazar, Juan/AFQ-6683-2022; GARCIA-VIGUERA, CRISTINA/AAH-2013-2021;
   GARCIA-VIGUERA, CRISTINA/B-2153-2012; Pinto-Almazan,
   Rodolfo/F-3483-2013; Moreno-Fernandez, Diego Angel/G-4379-2011;
   Loza-Mejia, Marco A./F-3557-2019
OI GARCIA-VIGUERA, CRISTINA/0000-0002-4751-3917; Pinto-Almazan,
   Rodolfo/0000-0002-5210-5395; GALLARDO, Juan Manuel/0000-0001-8833-4651;
   Chavez Gutierrez, Edwin/0000-0002-8571-4111; Moreno-Fernandez, Diego
   Angel/0000-0002-6547-8764; Loza-Mejia, Marco A./0000-0002-8449-0806;
   Almanza-Perez, Julio/0000-0002-9417-5500
FU CONACyT [785220]
FX This work was submitted in partial fulfillment of the requirements for
   the Ph.D. degree of Emily Leonela Castillo Garcia at Doctorado en
   Ciencias Biologicas y de la Salud (UAM-I). Emily Leonela Castillo Garcia
   received financial support from CONACyT (785220).
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NR 54
TC 2
Z9 2
U1 0
U2 7
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2218-1989
J9 METABOLITES
JI Metabolites
PD DEC
PY 2023
VL 13
IS 12
AR 1189
DI 10.3390/metabo13121189
PG 16
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA DL0T5
UT WOS:001132087800001
PM 38132871
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Dyball, D
   Evans, S
   Boos, CJ
   Steyelink, SAM
   Fear, NT
AF Dyball, Daniel
   Evans, Sarah
   Boos, Christopher J.
   Steyelink, Sharon A. M.
   Fear, Nicola T.
TI The association between PTSD and cardiovascular disease and its risk
   factors in male veterans of the Iraq/Afghanistan conflicts: a systematic
   review
SO INTERNATIONAL REVIEW OF PSYCHIATRY
LA English
DT Review
DE Afghanistan; cardiovascular diseases; Iraq; military personnel; stress
   disorder; post-traumatic
ID POSTTRAUMATIC-STRESS-DISORDER; HEART-RATE-VARIABILITY; COMBAT-RELATED
   PTSD; BLOOD-PRESSURE; METABOLIC SYNDROME; INFLAMMATORY MARKERS;
   INSULIN-RESISTANCE; AFGHANISTAN; DEPRESSION; MORTALITY
AB Military personnel with Post-Traumatic Stress Disorder (PTSD) can experience high levels of mental and physical health comorbidity, potentially indicating a high level of functional impairment that can impact on both military readiness and later ill-health. There is strong evidence to implicate PTSD as a contributory factor to Cardiovascular Disease (CVD) among serving personnel and veterans. This systematic review focusses on the association between PTSD and cardiovascular disease/risk factors in male, military serving and ex-serving personnel who served in the Iraq/Afghanistan conflicts. PUBMED, MEDLINE, PILOTS, EMBASE, PSYCINFO, and PSYCARTICLES were searched using PRISMA guidelines. Three hundred and forty-three records were identified, of which 20 articles were selected. PTSD was positively associated with the development of CVD, specifically circulatory diseases, including hypertension. PTSD was also positively associated with the following risk factors: elevated heart rate, tobacco use, dyslipidaemia, and obesity. Conflicting data is presented regarding heart rate variability and inflammatory markers. Future studies would benefit from a standardized methodological approach to investigating PTSD and physical health manifestations. It is suggested that clinicians offer health advice for CVD at an earlier age for ex-/serving personnel with PTSD.
C1 [Dyball, Daniel; Evans, Sarah; Steyelink, Sharon A. M.; Fear, Nicola T.] Kings Coll London, Kings Ctr Mil Hlth Res, Psychol Med, London, England.
   [Dyball, Daniel; Evans, Sarah; Boos, Christopher J.; Fear, Nicola T.] Def Med Rehabil Ctr, Acad Dept Mil Rehabil, ADV Study, Stanford Hall, Loughborough, Leics, England.
   [Boos, Christopher J.] Bournemouth Univ, Dept Postgrad Med Educ, Poole, Dorset, England.
   [Steyelink, Sharon A. M.] Kings Coll London, Dept Psychol Med, London, England.
   [Fear, Nicola T.] Kings Coll London, Acad Dept Mil Mental Hlth, London, England.
C3 University of London; King's College London; Bournemouth University;
   University of London; King's College London; University of London;
   King's College London
RP Dyball, D (corresponding author), Kings Coll London, Kings Ctr Mil Hlth Res, Weston Educ Ctr, 10 Cutcombe Rd, London SE5 9RJ, England.
EM daniel.dyball@kcl.ac.uk
RI Fear, Nicola/A-1917-2012
OI Dyball, Daniel Mark/0000-0002-0547-8674; Stevelink,
   Sharon/0000-0002-7655-7986; Fear, Nicola/0000-0002-5792-2925; Evans,
   Sarah/0000-0002-6390-6729
FU Help for Heroes; Her Majesty's Treasury
FX The ADVANCE Study is funded by research grants from Help for Heroes and
   from Her Majesty's Treasury.
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NR 89
TC 35
Z9 40
U1 1
U2 11
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0954-0261
EI 1369-1627
J9 INT REV PSYCHIATR
JI Int. Rev. Psych.
PD JAN 2
PY 2019
VL 31
IS 1
SI SI
BP 34
EP 48
DI 10.1080/09540261.2019.1580686
PG 15
WC Psychiatry
WE Social Science Citation Index (SSCI)
SC Psychiatry
GA IG0OD
UT WOS:000473489100005
PM 31041877
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Ma, L
   Li, Y
AF Ma, Lina
   Li, Yun
TI SIRT1: Role in cardiovascular biology
SO CLINICA CHIMICA ACTA
LA English
DT Review
DE SIRT1; Senescence; Cardiovascular biology; Expression regulation
ID ACTIVATED PROTEIN-KINASE; SMALL-MOLECULE ACTIVATORS; MYOCARDIAL
   GLUCOSE-UPTAKE; CARDIAC-HYPERTROPHY; METABOLIC SYNDROME; DEACETYLASE
   SIRT1; OXIDATIVE STRESS; MITOCHONDRIAL-FUNCTION; HISTONE DEACETYLASE;
   CELLULAR SENESCENCE
AB SIRT1 (silent information regulator two protein) is a type III protein deacetylase that regulates a variety of important metabolic and physiologic processes including stress resistance, metabolism, apoptosis and energy balance. It-reverses cholesterol transport and reduces risk for development of atherosclerosis and cardiovascular disease. The following review highlights the potential role of SIRT1 on cardiovascular biology and function. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Ma, Lina; Li, Yun] Capital Med Univ, Xuan Wu Hosp, Dept Geriatr, Beijing 100053, Peoples R China.
C3 Capital Medical University
RP Li, Y (corresponding author), Capital Med Univ, Xuan Wu Hosp, Dept Geriatr, 45 Changchun St, Beijing 100053, Peoples R China.
EM liy_xw@sina.com
RI Ma, Lina/R-6802-2016
OI Ma, Lina/0000-0001-7630-6960
FU MOE (Ministry of Education in China) Project of Humanities and Social
   Sciences [12YJCZH146]; Beijing Municipal Health Bureau Research Fund
   [Jing 13-02]
FX This work was supported by the following grants: MOE (Ministry of
   Education in China) Project of Humanities and Social Sciences
   (12YJCZH146), and Beijing Municipal Health Bureau Research Fund (Jing
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NR 132
TC 49
Z9 54
U1 1
U2 20
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0009-8981
EI 1873-3492
J9 CLIN CHIM ACTA
JI Clin. Chim. Acta
PD FEB 2
PY 2015
VL 440
BP 8
EP 15
DI 10.1016/j.cca.2014.10.036
PG 8
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA CB4BT
UT WOS:000349573900004
PM 25444742
DA 2025-06-11
ER

PT J
AU das Merces, MC
   Santana, AIC
   Lua, I
   da Silva, DAR
   Silva, DDE
   Gomes, AMT
   Miranda, MCD
   Barbosa, CD
   Magalhaes, LBNC
   Coelho, JMF
   Servo, MLS
   Portella, DDA
   de Souza, MC
   Lago, SB
   Araújo, EMQ
   Marques, SC
   Figueiredo, VP
   D'Oliveira, A
AF das Merces, Magno Conceicao
   Costa Santana, Amalia Ivine
   Lua, Iracema
   Reis da Silva, Dandara Almeida
   de Souza e Silva, Douglas
   Tosoli Gomes, Antonio Marcos
   das Merces Miranda, Manuela Conceicao
   Barbosa, Caroline da Silva
   Neves Cunha Magalhaes, Lucelia Batista
   Freitas Coelho, Julita Maria
   Silva Servo, Maria Lucia
   Alves Portella, Daniel Deivson
   de Souza, Marcio Costa
   Lago, Sueli Bonfim
   Queiroz Araujo, Edilene Maria
   Marques, Sergio Correa
   Figueiredo, Virginia Paiva
   D'Oliveira Junior, Argemiro
TI Metabolic Syndrome Among Primary Health Care Nursing Professionals: A
   Cross-Sectional Population-Based Study
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Article
DE metabolic syndrome; nursing; primary health care; work
ID CARDIOVASCULAR-DISEASE; INSULIN-RESISTANCE; PREVALENCE; EXERCISE;
   STRESS; ASSOCIATION; OVERWEIGHT; PROGRAM; OBESITY; WORKERS
AB This research aims at evaluating prevalence and factors associated with metabolic syndrome (MS) in primary health care (PHC) nursing professionals. A multicenter, population-based and cross-sectional study was conducted in a team-tested sample of 1125 PHC nurses in the state of Bahia, Brazil. Sociodemographic, labor, lifestyle and human biology variables were investigated by mean of anamnesis. MS was evaluated according to the criteria of the first Brazilian Guideline for Metabolic Syndrome, which fully adopts the criteria of the National Cholesterol Education Program's Adult Treatment Panel III. MS-associated factors were tested by using robust Poisson Regression. The prevalence of MS found was 24.4%; low High Density Lipoprotein (HDL) cholesterol was the most prevalent component of the syndrome. In the multivariate analysis, physical inactivity (PR = 1.25, 95% CI = 1.02-1.53), alcohol use (PR = 1.84, 95% CI = 1.22-2.77), acanthosis nigricans (PR = 3.23, 95% CI = 2.65-3.92), burnout syndrome (PR = 1.45, 95% CI = 1.17-1.81), (PR = 1.37, 95% CI = 1.12-1.69), working as a nursing technician (PR = 1.43, 95% CI = 1.14-1.80), were associated to MS. It was found that the prevalence of MS was high, which evidences the need for interventions in the PHC environment, improvement of working conditions, monitoring of worker safety and health, diet programs and physical activity.
C1 [das Merces, Magno Conceicao; Reis da Silva, Dandara Almeida; das Merces Miranda, Manuela Conceicao; Freitas Coelho, Julita Maria; Alves Portella, Daniel Deivson; de Souza, Marcio Costa; Lago, Sueli Bonfim; Queiroz Araujo, Edilene Maria] State Univ Bahia UNEB, Dept Life Sci, BR-41150000 Salvador, BA, Brazil.
   [das Merces, Magno Conceicao; Costa Santana, Amalia Ivine; de Souza e Silva, Douglas; Barbosa, Caroline da Silva; D'Oliveira Junior, Argemiro] Fed Univ Bahia UFBA, Sch Med, Hlth Sci Postgrad Program, BR-40026010 Salvador, BA, Brazil.
   [Lua, Iracema; Silva Servo, Maria Lucia] State Univ Feira de Santana UEFS, Dept Hlth, BR-44036900 Feira De Santana, Brazil.
   [Tosoli Gomes, Antonio Marcos; Marques, Sergio Correa; Figueiredo, Virginia Paiva] State Univ Rio de Janeiro UERJ, Sch Nursing, BR-20551030 Rio De Janeiro, Brazil.
   [Neves Cunha Magalhaes, Lucelia Batista] Fed Univ Bahia UFBA, Sch Med, Dept Family Hlth, BR-40026010 Salvador, BA, Brazil.
C3 Universidade do Estado Bahia; Universidade Estadual de Feira de Santana;
   Universidade do Estado do Rio de Janeiro
RP das Merces, MC (corresponding author), State Univ Bahia UNEB, Dept Life Sci, BR-41150000 Salvador, BA, Brazil.; das Merces, MC (corresponding author), Fed Univ Bahia UFBA, Sch Med, Hlth Sci Postgrad Program, BR-40026010 Salvador, BA, Brazil.
EM magnomerces@hotmail.com
RI Lua, Iracema/AAR-2466-2021; MAGALHÃES, LUCELIA/AAA-1378-2019; Merces,
   Magno/S-6649-2017; Gomes, A./Q-6844-2016; Costa de Souza,
   Marcio/Y-8859-2018
OI DE SOUZA E SILVA, DOUGLAS/0000-0003-4476-7767; Merces, Magno Conceicao
   das/0000-0003-3493-8606; Maria Queiroz Araujo,
   Edilene/0000-0003-0481-037X; Deivson Alves Portella,
   Daniel/0000-0002-0315-9987; Coelho, Julita/0000-0002-9520-5177; Costa de
   Souza, Marcio/0000-0002-4922-6786
FU National Council for Scientific and Technological Development (CNPq),
   Brazil [408390/2016-6]
FX Financial support from the National Council for Scientific and
   Technological Development (CNPq), Brazil, Universal Call Notice-protocol
   #408390/2016-6.
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NR 48
TC 21
Z9 21
U1 0
U2 4
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD AUG 1
PY 2019
VL 16
IS 15
AR 2686
DI 10.3390/ijerph16152686
PG 13
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA IS4MU
UT WOS:000482128400055
PM 31357596
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU More, VR
   Xu, JL
   Shimpi, PC
   Belgrave, C
   Luyendyk, JP
   Yamamoto, M
   Slitt, AL
AF More, Vijay R.
   Xu, Jialin
   Shimpi, Prajakta C.
   Belgrave, Clyde
   Luyendyk, James P.
   Yamamoto, Masayuki
   Slitt, Angela L.
TI Keap1 knockdown increases markers of metabolic syndrome after long-term
   high fat diet feeding
SO FREE RADICAL BIOLOGY AND MEDICINE
LA English
DT Article
DE Nrf2; Keap1; Steatosis; Metabolic syndrome; Free radicals
ID GENE-EXPRESSION; INSULIN-RESISTANCE; INDUCED OBESITY; TRANSPORTER
   EXPRESSION; NRF2 ACTIVATION; ADIPOSE-TISSUE; LIVER-INJURY; MOUSE-LIVER;
   MICE; DISEASE
AB The nuclear factor E2-related factor 2 (Nrf2)-Kelch-like ECH-associated protein 1 (Keap1) pathway upregulates antioxidant and biotransformation enzyme expression to counter cellular oxidative stress. The contributions of Nrf2 to other cellular functions, such as lipid homeostasis, are emerging. This study was conducted to determine how enhanced Nrf2 activity influences the progression of metabolic syndrome with long-term high-fat diet (HFD) feeding. C57BL/6 and Keap1-knockdown (Keap1-KD) mice, which exhibit enhanced Nrf2 activity, were fed a HFD for 24 weeks. Keap1-KD mice had higher body weight and white adipose tissue mass compared to C57BL/6 mice on HFD, along with increased inflammation and lipogenic gene expression. HFD feeding increased hepatic steatosis and inflammation to a greater extent in Keap1-KD mice compared to C57BL/6 mice, which was associated with increased liver Cd36, fatty acid-binding protein 4, and monocyte chemoattractant protein 1 mRNA expression, as well as increased acetyl-CoA carboxylase 1 and stearoyl-CoA desaturase-1 protein expression. The HFD altered short-term glucose homeostasis to a greater degree in Keap-KD mice compared to C57BL/6 mice, which was accompanied by downregulation of insulin receptor substrate 1 mRNA expression in skeletal muscle. Together, the results indicate that Keap1 knockdown, on treatment with HFD, increases certain markers of metabolic syndrome. (C) 2013 Elsevier Inc. All rights reserved.
C1 [More, Vijay R.; Xu, Jialin; Shimpi, Prajakta C.; Slitt, Angela L.] Univ Rhode Isl, Dept Biomed & Pharmaceut Sci, Kingston, RI 02881 USA.
   [Belgrave, Clyde] Providence VA Med Ctr, Providence, RI 02908 USA.
   [Luyendyk, James P.] Michigan State Univ, E Lansing, MI 48824 USA.
   [Yamamoto, Masayuki] Tohoku Univ, Div Med Biochem, Grad Sch Med, Sendai, Miyagi 980, Japan.
C3 University of Rhode Island; US Department of Veterans Affairs; Veterans
   Health Administration (VHA); Providence VA Medical Center; Michigan
   State University; Tohoku University
RP Slitt, AL (corresponding author), Univ Rhode Isl, Dept Biomed & Pharmaceut Sci, Kingston, RI 02881 USA.
EM aslitt@uri.edu
RI Yamamoto, Masayuki/A-4873-2010
FU National Institutes of Health [1R01ES016042, 5K22ES013782]; National
   Center for Research Resources [5P20RR016457-11]; Institute for General
   Medical Science components of the National Institutes of Health [8P20
   GM103430-11]; Society of Toxicology Association of Scientists of Indian
   Origin
FX The authors thank Dr. Curtis D. Klaassen (University of Kansas Medical
   School) for generously sharing Keap1-KD mice. This work was supported by
   grants from the National Institutes of Health (1R01ES016042,
   5K22ES013782) and the National Center for Research Resources
   (5P20RR016457-11) and Institute for General Medical Science (8P20
   GM103430-11) components of the National Institutes of Health. This work
   was presented, in part, at the annual Society of Toxicology meeting held
   in San Francisco on 11-15 March 2012 and was awarded the Dr. Laxman
   Desai Graduate Student Best Abstract Award from the Society of
   Toxicology Association of Scientists of Indian Origin.
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NR 49
TC 46
Z9 54
U1 0
U2 17
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0891-5849
J9 FREE RADICAL BIO MED
JI Free Radic. Biol. Med.
PD AUG
PY 2013
VL 61
BP 85
EP 94
DI 10.1016/j.freeradbiomed.2013.03.007
PG 10
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 168EA
UT WOS:000320687300010
PM 23507082
OA Green Accepted, Green Published
DA 2025-06-11
ER

PT J
AU Kagota, S
   Yamaguchi, Y
   Tanaka, N
   Kubota, Y
   Kobayashi, K
   Nejime, N
   Nakamura, K
   Kunitomo, M
   Shinozuka, K
AF Kagota, S
   Yamaguchi, Y
   Tanaka, N
   Kubota, Y
   Kobayashi, K
   Nejime, N
   Nakamura, K
   Kunitomo, M
   Shinozuka, K
TI Disturbances in nitric oxide/cyclic guanosine monophosphate system in
   SHR/NDmcr-cp rats, a model of metabolic syndrome
SO LIFE SCIENCES
LA English
DT Article
DE endothelium; metabolic syndrome; nitric oxide; vascular smooth muscle;
   vasorelaxation
ID SOLUBLE GUANYLYL CYCLASE; SPONTANEOUSLY HYPERTENSIVE-RATS; OBESE ZUCKER
   RAT; LA-CORPULENT RAT; INSULIN-RESISTANCE; OXIDE SYNTHASE; VASCULAR
   DYSFUNCTION; ENDOTHELIAL FUNCTION; DOWN-REGULATION; NO SYNTHASE
AB Metabolic syndrome is a cluster of metabolic abnormalities, including hypertension, hyperlipidemia, hyperinsulinemia, glucose intolerance and obesity. In such lifestyle-related diseases, impairment of nitric oxide (NO) production or bioactivity has been reported to lead to the development of atherogenic vascular diseases. Therefore, in the present study we investigated changes in the NO/cyclic guanosine monophosphate (cGMP) system in aortas of SHR/NDmcr-cp (cp/cp) rats (SHR-cp), a model of the metabolic syndrome. In aortas of SHR-cp, endothelium-dependent relaxations induced by acetylcholine and endothelium-independent relaxations induced by sodium nitroprusside were significantly impaired in comparison with Wistar-Kyoto rats. Furthermore, protein levels of soluble guanyly cyclase and cGMP levels induced by sodium nitroprusside were significantly decreased. In contrast, protein levels of endothelium NO synthase and cGMP levels induced by acetylcholine were significantly increased, and plasma NO2 plus NO3 levels were also increased. The levels of lipid peroxide in plasma and the contents of 3-nitrotyrosine, a biomarker of peroxynitrite, in aortas were markedly increased. These findings indicate that in the aortas of SHR-cp, NO production from the endothelium, is augmented, although the NO-induced relaxation response is impaired. Enhanced NO production may be a compensatory response to a variety of factors, including increases in oxidative stress. (c) 2005 Elsevier Inc. All rights reserved.
C1 Mukogawa Womens Univ, Sch Pharmaceut Sci, Dept Pharmacol, Nishinomiya, Hyogo, Japan.
C3 Mukogawa Women's University
RP Kagota, S (corresponding author), 11-68 Koshien Kyuban Cho, Nishinomiya, Hyogo 6638179, Japan.
EM skagota@mwu.mukogawa-u.ac.jp
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NR 36
TC 49
Z9 55
U1 0
U2 2
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0024-3205
J9 LIFE SCI
JI Life Sci.
PD FEB 9
PY 2006
VL 78
IS 11
BP 1187
EP 1196
DI 10.1016/j.lfs.2005.06.029
PG 10
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA 013IC
UT WOS:000235402000007
PM 16188278
DA 2025-06-11
ER

PT J
AU Oh, EG
   Bang, SY
   Kim, SH
   Hyun, SS
   Chu, SH
   Jeon, JY
   Im, JA
   Lee, JE
   Lee, MK
AF Oh, Eui Geum
   Bang, So Youn
   Kim, Soo Hyun
   Hyun, Sa Saeng
   Chu, Sang Hui
   Jeon, Justin Y.
   Im, Jee Aee
   Lee, Jung Eun
   Lee, Mi Kyung
TI Therapeutic Lifestyle Modification Program Reduces Plasma Levels of the
   Chemokines CRP and MCP-1 in Subjects With Metabolic Syndrome
SO BIOLOGICAL RESEARCH FOR NURSING
LA English
DT Article
DE metabolic syndrome; lifestyle modification; inflammation
ID PULSE-WAVE VELOCITY; ENDOTHELIAL FUNCTION; WEIGHT-LOSS; OXIDATIVE
   STRESS; RISK; CARBOHYDRATE; RESTRICTION; ADIPONECTIN; PROMOTES; ADULTS
AB Objective: The purpose of this study was to examine the effects of a 6-month therapeutic lifestyle modification (TLM) program on chemokines related to oxidative stress, inflammation, endothelial dysfunction, and arterial stiffness in subjects with metabolic syndrome (MetS). Methods: The authors performed a randomized controlled trial, assigning 52 women (mean age 62.7 +/- 9.0 years) with MetS to a TLM intervention group (n = 31) or a control group (n 21). The authors provided the TLM intervention group with health screening, exercise, low-calorie diet, and health education and counseling for 6 months and instructed the control group to maintain their usual lifestyle behaviors. Outcome variables included levels of myeloperoxidase (MPO), oxidized low-density lipoprotein (LDL), adiponectin, leptin, resistin, high-sensitivity C-reactive protein (hs-CRP), interleukin-1 beta, interleukin-6, tumor necrosis factor-alpha (TNF-alpha), CD40L, monocyte chemotactic protein-1 (MCP-1), retinol-binding protein 4 (RBP-4), endothelin-1, and brachial-ankle pulse wave velocity. The authors used generalized estimating equation (GEE) analyses to estimate the effects of the TLM program. Results: After the 6-month TLM program, hs-CRP levels decreased significantly, and MCP-1 levels increased at a significantly slower rate in the TLM group than they did in the control group (all p < .05). Conclusion: These results indicate that a TLM program could be effective for improving patient inflammatory states and may also be effective in preventing cardiovascular complications in subjects with MetS.
C1 [Oh, Eui Geum] Yonsei Univ, Coll Nursing Nursing Policy & Res Inst, Div Clin Nursing Sci Adult Hlth Nursing, Seoul 120752, South Korea.
   [Kim, Soo Hyun] Inha Univ, Dept Nursing, Inchon, South Korea.
   [Hyun, Sa Saeng] Galsan Publ Hlth Care Ctr, Chungbuk, South Korea.
   [Jeon, Justin Y.; Lee, Mi Kyung] Yonsei Univ, Dept Sport & Leisure Studies, Seoul 120752, South Korea.
   [Im, Jee Aee] InToTo Inc, Seoul, South Korea.
C3 Yonsei University; Yonsei University Health System; Inha University;
   Yonsei University
RP Oh, EG (corresponding author), Yonsei Univ, Coll Nursing Nursing Policy & Res Inst, Div Clin Nursing Sci Adult Hlth Nursing, 250 Seongsan Ro, Seoul 120752, South Korea.
EM euigeum@yuhs.ac
RI Lee, Jee-Yon/GER-4141-2022
OI CHU, Sang Hui/0000-0001-6877-5599; Lee, Jung Eun/0000-0002-1195-3427;
   Jeon, Justin/0000-0001-7978-4271; Lee, Mi Kyung/0000-0002-9690-4463; Oh,
   Eui Geum/0000-0002-6941-0708
FU Korean Science and Engineering Foundation [R01-2006-000-11333-0]
FX The authors disclosed receipt of the following financial support for the
   research, authorship, and/or publication of this article: This work was
   supported by the Korean Science and Engineering Foundation
   (R01-2006-000-11333-0).
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NR 38
TC 23
Z9 25
U1 0
U2 12
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1099-8004
EI 1552-4175
J9 BIOL RES NURS
JI Biol. Res. Nurs.
PD JAN
PY 2013
VL 15
IS 1
BP 48
EP 55
DI 10.1177/1099800411416637
PG 8
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nursing
GA 040OT
UT WOS:000311332900006
PM 21859748
DA 2025-06-11
ER

PT J
AU Singh, RB
   Gupta, S
   Dherange, P
   De Meester, F
   Wilczynska, A
   Alam, SE
   Pella, D
   Wilson, DW
AF Singh, Ram B.
   Gupta, Siddharth
   Dherange, Parinita
   De Meester, Fabien
   Wilczynska, Agnieszka
   Alam, Shaan E.
   Pella, Daniel
   Wilson, Douglas W.
TI Metabolic syndrome: a brain disease
SO CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
LA English
DT Review
DE hypothalamus; glucose intolerance; insulin resistance; brain disease;
   diet; nutrition; omega-3 fatty acids; brain development; brain-heart
   connection; Mediterranean diet
ID POLYUNSATURATED FATTY-ACIDS; CORONARY-ARTERY DISEASE; INSULIN-RECEPTOR;
   BLOOD-PRESSURE; ARCUATE NUCLEUS; TNF-ALPHA; RISK-FACTORS; VAGUS NERVE;
   ACETYLCHOLINE; RELEASE
AB Recent research indicates an association between brain dysfunction and the pathogenesis of metabolic syndrome. To investigate this, we created a Medline search (up to December 2011) of articles in PubMed. The results indicated that refined carbohydrates, saturated and total fat, high levels of omega-6 fatty acids, and low levels of omega-3 fatty acids and other long chain polyunsaturated fatty acids (PUFA), all in conjunction with sedentary behaviour and mental stress can predispose to inflammation. Increased sympathetic activity, with increased secretion of catecholamine, cortisol, and serotonin can cause oxidative stress, which may damage the arcuate nucleus as well as the hypothalamus and macrophages, and the liver may release pro-inflammatory cytokines. These, in conjunction with an underlying deficiency in long chain PUFA, may damage the arcuate nucleus as well as neuropeptide-Y and pro-opiomelanocortin neurons and insulin receptors in the brain, especially during fetal life, infancy, and childhood, resulting in their dysfunction. Of the fatty acids in the brain, 30%-50% are long chain PUFA, which are incorporated in the cell membrane phospholipids. Hence, omega-3 fatty acids, which are also known to enhance parasympathetic activity and increase the secretion of anti-inflammatory cytokines interleukin (IL)-4 and IL-10 as well as acetylcholine in the hippocampus, may be protective. Therefore, treatment with omega-3 fatty acids may be applied for the prevention of metabolic syndrome.
C1 [Singh, Ram B.; Gupta, Siddharth; Dherange, Parinita; De Meester, Fabien; Wilczynska, Agnieszka] TsimTsoum Inst, PL-40126 Krakow, Silesia, Poland.
   [Alam, Shaan E.] Univ Coll Med Sci, Delhi 190095, India.
   [Pella, Daniel] PJ Safaric Univ, Interna Klin FNSP, Dept Med 3, Kosice 04011, Slovakia.
   [Wilson, Douglas W.] Sch Med & Hlth, Durham TS17 6BH, England.
C3 University of Delhi; University College of Medical Sciences
RP Singh, RB (corresponding author), TsimTsoum Inst, Golebia St, PL-40126 Krakow, Silesia, Poland.
EM rbs@tsimtsoum.net
OI Gupta, Siddharth/0000-0002-1948-0847; Pella, Daniel/0000-0001-9999-6271
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NR 86
TC 43
Z9 46
U1 0
U2 37
PU CANADIAN SCIENCE PUBLISHING
PI OTTAWA
PA 65 AURIGA DR, SUITE 203, OTTAWA, ON K2E 7W6, CANADA
SN 0008-4212
EI 1205-7541
J9 CAN J PHYSIOL PHARM
JI Can. J. Physiol. Pharmacol.
PD SEP
PY 2012
VL 90
IS 9
BP 1171
EP 1183
DI 10.1139/Y2012-122
PG 13
WC Pharmacology & Pharmacy; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Physiology
GA 997GI
UT WOS:000308152200004
PM 22913633
DA 2025-06-11
ER

PT J
AU Tirosh, A
   Garg, R
   Adler, GK
AF Tirosh, Amir
   Garg, Rajesh
   Adler, Gail K.
TI Mineralocorticoid Receptor Antagonists and the Metabolic Syndrome
SO CURRENT HYPERTENSION REPORTS
LA English
DT Article
DE Aldosterone; Mineralocorticoid receptor; Obesity; Insulin resistance;
   Spironolactone; Eplerenone
ID ANGIOTENSIN-ALDOSTERONE SYSTEM; CHRONIC KIDNEY-DISEASE;
   INSULIN-RESISTANCE; CARDIOVASCULAR-DISEASE; GLUCOSE; SPIRONOLACTONE;
   DYSFUNCTION; EPLERENONE; ADIPONECTIN; SENSITIVITY
AB Key components of the metabolic syndrome (MetS), ie, obesity and insulin resistance, are associated with increased aldosterone production and mineralocorticoid receptor (MR) activation. Both MetS and hyperaldosteronism are proinflammatory and pro-oxidative states associated with cardiovascular disease. This review discusses emerging data that MR activation may contribute to abnormalities seen in MetS. In view of these data, MR antagonists may be beneficial in MetS, not only by controlling hypertension but also by reversing inflammation, oxidative stress, and defective insulin signaling at the cellular-molecular level. Clinical trials have demonstrated benefits of MR antagonists in heart failure, hypertension, and diabetic nephropathy, but additional trials are needed to demonstrate the clinical significance of MR blockade in MetS.
C1 [Tirosh, Amir; Garg, Rajesh; Adler, Gail K.] Harvard Univ, Sch Med, Brigham & Womens Hosp, Div Endocrinol Diabet & Hypertens, Boston, MA 02115 USA.
C3 Harvard University; Harvard Medical School; Harvard University Medical
   Affiliates; Brigham & Women's Hospital
RP Adler, GK (corresponding author), Harvard Univ, Sch Med, Brigham & Womens Hosp, Div Endocrinol Diabet & Hypertens, 221 Longwood Ave, Boston, MA 02115 USA.
EM atirosh@partners.org; rgarg@partners.org; gadler@partners.org
OI Garg, Rajesh/0000-0002-7779-1619; Tirosh, Amir/0000-0003-2210-5906;
   Adler, Gail/0000-0003-3506-7347
FU National Institutes of Health [R01HL 087060]
FX This work is supported in part by a grant from the National Institutes
   of Health, R01HL 087060 (GKA and RG).
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NR 50
TC 57
Z9 64
U1 0
U2 6
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1522-6417
EI 1534-3111
J9 CURR HYPERTENS REP
JI Curr. Hypertens. Rep.
PD AUG
PY 2010
VL 12
IS 4
BP 252
EP 257
DI 10.1007/s11906-010-0126-2
PG 6
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 669LZ
UT WOS:000283353600007
PM 20563672
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Shatylo, V
   Antoniuk-Shcheglova, I
   Naskalova, S
   Bondarenko, O
   Havalko, A
   Krasnienkov, D
   Zabuga, O
   Kukharskyy, V
   Guryanov, V
   Vaiserman, A
AF Shatylo, Valerii
   Antoniuk-Shcheglova, Ivanna
   Naskalova, Svitlana
   Bondarenko, Olena
   Havalko, Anna
   Krasnienkov, Dmytro
   Zabuga, Oksana
   Kukharskyy, Vitaliy
   Guryanov, Vitaly
   Vaiserman, Alexander
TI Cardio-metabolic benefits of quercetin in elderly patients with
   metabolic syndrome
SO PHARMANUTRITION
LA English
DT Article
DE Quercetin; Phyto-bioactive compound; Antioxidant; Metabolic syndrome;
   Lipid profile; Glycemic control
ID BLOOD-PRESSURE; DOUBLE-BLIND; INFLAMMATION; EPICATECHIN; STRESS; ADULTS
AB Background: Quercetin is regarded as a promising phytochemical in treating metabolic syndrome (MetS).
   Methods: Present study is a randomized, placebo-controlled, double-blind clinical trial aimed at evaluating effects of quercetin on different aspects of MetS in patients aged 60 + . Study participants consumed two quercetincontaining or placebo tablets 3 times per day (daily dose = 240 mg) during 3 months.
   Results: Quercetin administration decreased body weight (-0.32 kg; p = 0.007) and body mass index (-0.12 kg/ m(2); p = 0.01). The blood pressure was also decreased: systolic blood pressure: -7.7 mm Hg (p < 0.001), diastolic blood pressure: -4.1 mm Hg (p = 0.001) relative to baseline values; these effects remained statistically significant after controlling for age, sex and body mass index. Quercetin intervention also improved cholesterol metabolism (serum total cholesterol: -0.44 mmol/L; p = 0.003; low-density lipoprotein cholesterol: -0.41 mmol/L; p = 0.007) and decreased fasting plasma insulin (-2.01 mu U/mL; p = 0.02) and glucose level at 2-hour oral glucose tolerance test (-0.78 mmol/L; p = 0.004). Telomere length and markers of oxidative stress were mostly unchanged except for glutathione level which was significantly decreased (-0.24 mu M/L; p = 0.005) in the quercetin-treated group.
   Conclusion: These findings indicate that quercetin may be effective in treating MetS. This trial was registered by Ukrainian Registry of Clinical Trials on October 30, 2017 (registration No1339).
C1 [Shatylo, Valerii; Antoniuk-Shcheglova, Ivanna; Naskalova, Svitlana; Bondarenko, Olena; Havalko, Anna; Krasnienkov, Dmytro; Zabuga, Oksana; Kukharskyy, Vitaliy; Vaiserman, Alexander] NAMS Ukraine, DF Chebotarev State Inst Gerontol, UA-04114 Kiev, Ukraine.
   [Guryanov, Vitaly] Bogomolets Natl Med Univ, UA-02000 Kiev, Ukraine.
C3 National Academy of Medical Sciences of Ukraine; D. F. Chebotarev
   Institute of Gerontology of the National Academy of Medical Sciences of
   Ukraine; Bogomolets National Medical University
RP Vaiserman, A (corresponding author), Inst Gerontol, Vyshgorodskaya St 67, UA-04114 Kiev, Ukraine.
EM vaiserman@geront.kiev.ua
RI Бондаренко, Олена/GRF-6169-2022; Gurianov, Vitaliy/LWK-2758-2024;
   Antoniuk-Shcheglova, Ivanna/JTS-3444-2023; Naskalova,
   Svitlana/JTS-3732-2023; Shatylo, Valeriy/JXY-3176-2024
OI Naskalova, Svitlana/0000-0001-9518-2633; Shatylo,
   Valeriy/0000-0001-7114-9150; Gurianov, Vitaly/0000-0001-8509-6301;
   Zabuha, Oksana/0000-0001-8400-185X
FU National Academy of Medical Sciences of Ukraine [0117U001419]
FX This research was realized with the support of the National Academy of
   Medical Sciences of Ukraine, the state registration number 0117U001419.
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NR 39
TC 13
Z9 14
U1 1
U2 8
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2213-4344
J9 PHARMANUTRITION
JI PharmaNutrition
PD MAR
PY 2021
VL 15
AR 100250
DI 10.1016/j.phanu.2020.100250
EA JAN 2021
PG 7
WC Chemistry, Medicinal; Geriatrics & Gerontology; Gerontology; Nutrition &
   Dietetics; Pharmacology & Pharmacy
WE Emerging Sources Citation Index (ESCI)
SC Pharmacology & Pharmacy; Geriatrics & Gerontology; Nutrition & Dietetics
GA SG4XK
UT WOS:000653444400002
DA 2025-06-11
ER

PT J
AU Rosenson, RS
AF Rosenson, Robert S.
TI Treatment of Hypertension in Metabolic Syndrome Subjects with Amlodipine
   and Olmesartan-Effects on Oxidized Non-Esterified Free Fatty Acids and
   Cytokine Production
SO CARDIOVASCULAR DRUGS AND THERAPY
LA English
DT Article
DE Hypertension; Oxidative stress; Calcium channel blockers; Angiotensin
   receptor antagonists
ID DENSITY-LIPOPROTEIN OXIDATION; CONVERTING ENZYME-INHIBITOR;
   ATHEROSCLEROSIS; ANTAGONIST; EXPRESSION; LOSARTAN; MONKEYS; MUSCLE; DIET
AB Angiotensin II increases activation of oxidative signaling and vascular inflammatory gene expression, and interruption of the renin-angiotensin system has been considered more vasculoprotective than use of calcium channel antagonists and other anti-hypertensive therapies. Despite these putative mechanisms, amlodipine is equally efficacious as other therapies in reducing cardiovascular events.
   Double-blind, controlled trial, designed to investigate the effects of 2-months treatment with amlodipine and olmesartan on oxidized non-esterified fatty acids (ox-NEFA), and lipopolysaccharide-stimulated cytokine production in whole blood among 23 hypertensive subjects with the metabolic syndrome.
   Treatment with olmesartan was no different than amlodipine in changing concentrations of total oxidized fatty acids (p = 0.37), total ox-NEFA (p = 0.43) and 9, 10, 11, 12, 13, 14, 15 and 16 ox-NEFA concentrations. In contrast, 8 ox-NEFA increased (median [interquartile ranges] by 45.2% [5.3 to 50.0] in olmesartan-treated subjects) compared with a decrease of 18.4% (-45.1-13.9) in amlodipine-treated subjects (p = 0.03). Lipopolysaccharide-stimulated cytokine production and levels of soluble cellular adhesion molecules did not change with either treatment.
   Despite experimental data that demonstrates that angiotensin receptor antagonists reduce cellular oxidant stress and inflammation, olmesartan was not different than amlodipine in changing ox-NEFA and inflammatory markers in hypertensive subjects with the metabolic syndrome.
C1 [Rosenson, Robert S.] SUNY Downstate, Div Endocrinol Diabet & Metab, Dept Med, Brooklyn, NY 11203 USA.
   [Rosenson, Robert S.] SUNY Downstate, Div Cardiovasc Med, Dept Med, Brooklyn, NY 11203 USA.
C3 State University of New York (SUNY) System; SUNY Downstate Health
   Sciences University; State University of New York (SUNY) System; SUNY
   Downstate Health Sciences University
RP Rosenson, RS (corresponding author), SUNY Downstate, Div Endocrinol Diabet & Metab, Dept Med, 450 Clarkson Ave,Box 1205, Brooklyn, NY 11203 USA.
EM robert.rosenson@downstate.edu
RI Rosenson, Robert/MDS-6957-2025
FU Sankyo Pharma (Parsippany, NJ USA)
FX This study was supported by a research grant from Sankyo Pharma
   (Parsippany, NJ USA).
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NR 14
TC 4
Z9 4
U1 0
U2 0
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0920-3206
J9 CARDIOVASC DRUG THER
JI Cardiovasc. Drugs Ther.
PD AUG
PY 2009
VL 23
IS 4
BP 289
EP 294
DI 10.1007/s10557-009-6185-4
PG 6
WC Cardiac & Cardiovascular Systems; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Pharmacology & Pharmacy
GA 486GM
UT WOS:000269184200005
PM 19641984
DA 2025-06-11
ER

PT B
AU Kyrou, I
   Valsamakis, G
   Tsigos, C
AF Kyrou, Ioannis
   Valsamakis, George
   Tsigos, Constantine
BE Chrousos, GP
   Tsigos, C
TI The endocannabinoid system as a target for the treatment of visceral
   obesity and metabolic syndrome
SO STRESS, OBESITY, AND METABOLIC SYNDROME
SE Annals of the New York Academy of Sciences-Series
LA English
DT Article; Proceedings Paper
CT Bjorntorp Symposium on Stress, Obesity, and Metabolic Syndrome
CY APR 09-10, 2005
CL Athens, GREECE
SP Roche Hellas, Abbott Hellas, Pfizer Hellas, Sanofi Aventis Hellas, GlaxoSmithKline Hellas
DE endocannabinoids; cannabinoid receptors; obesity; metabolic syndrome;
   stress; cannabinoid receptor antagonists; rimonabant in obesity (RIO)
   studies
ID CANNABINOID CB1 RECEPTOR; CENTRAL-NERVOUS-SYSTEM; MESSENGER-RNA LEVELS;
   RAT CAUDATE-PUTAMEN; SIGNAL-TRANSDUCTION; RISK-FACTORS; MOLECULAR
   CHARACTERIZATION; ENDOGENOUS CANNABINOIDS; MONOGLYCERIDE LIPASE;
   ANTAGONIST SR141716
AB The endogenous cannabinoid system is a novel, remarkably elaborate physiological signaling system, comprising the recently identified endogenous cannabinoid ligands, their corresponding selective receptors, and the machinery of proteins and enzymes that is involved in their biosynthesis, release, transport, and degradation. This system extends widely in both the central nervous system (CNS) and the periphery and exhibits a variety of actions implicated in vital functions (e.g., behavioral, antinociceptive, neuroprotective, immunosuppressive, cardiovascular, and metabolic). Particular interest has been focused on the apparent participation of endocannabinoids in metabolic homeostasis by modulating the activity of CNS circuits that control food intake and energy expenditure, the neuroendocrine response of the stress system, and the metabolic functions of crucial peripheral tissues, such as the adipose tissue, the gastrointestinal tract, the liver, and the skeletal muscles. These effects are predominantly CB1 receptor mediated and, thus, selective antagonists of this receptor subtype are being vigorously investigated as potential therapeutic agents for the treatment of various metabolic derangements (e.g., obesity, insulin resistance, dyslipidemia, and metabolic syndrome). The first selective CB1 receptor antagonist, rimonabant, has already successfully completed phase III clinical trials as adjunctive obesity treatment, with significant improvements in several associated metabolic and cardiovascular risk factors that led to the recent approval of its clinical use by the Food and Drug Administration.
C1 Univ Athens, Sch Med, Evgenid Hosp, Endocrinol Metab & Diabet Unit, GR-11528 Athens, Greece.
   Hellen Natl Diabet Ctr, GR-10675 Athens, Greece.
C3 Athens Medical School; National & Kapodistrian University of Athens
RP Tsigos, C (corresponding author), 82 Vas Sophias Ave, GR-11528 Athens, Greece.
EM ctsigos@gmail.com
CR [Anonymous], HDB STRESS MED HLTH
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NR 128
TC 32
Z9 39
U1 0
U2 2
PU BLACKWELL SCIENCE PUBL
PI OXFORD
PA OSNEY MEAD, OXFORD OX2 0EL, ENGLAND
BN 978-1-57331-625-5
J9 ANN NY ACAD SCI
JI Ann.NY Acad.Sci.
PY 2006
VL 1083
BP 270
EP 305
DI 10.1196/annals.1367.024
PG 36
WC Endocrinology & Metabolism; Multidisciplinary Sciences
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Science & Technology - Other Topics
GA BFR90
UT WOS:000244102900018
PM 17148745
DA 2025-06-11
ER

PT J
AU Gong, K
   Zhang, Z
   Chen, SS
   Zhu, XR
   Wang, MY
   Yang, XY
   Ding, C
   Han, JH
   Li, QS
   Duan, YJ
AF Gong, Ke
   Zhang, Zhen
   Chen, Sha-sha
   Zhu, Xin-ran
   Wang, Meng-yao
   Yang, Xin-yue
   Ding, Chen
   Han, Ji-hong
   Li, Qing-shan
   Duan, Ya-jun
TI 6-Methyl flavone inhibits Nogo-B expression and improves high fructose
   diet-induced liver injury in mice
SO ACTA PHARMACOLOGICA SINICA
LA English
DT Article
DE metabolic syndrome; glycolipid metabolism; liver injury; high fructose;
   6-methyl flavone; Nogo-B
ID METABOLIC-DISORDERS; DISEASE; CHREBP; CELL; AUTOPHAGY; LIPOTOXICITY;
   ACTIVATION; BEVERAGES; OBESITY; CANCER
AB Excessive fructose consumption increases hepatic de novo lipogenesis, resulting in cellular stress, inflammation and liver injury. Nogo-B is a resident protein of the endoplasmic reticulum that regulates its structure and function. Hepatic Nogo-B is a key protein in glycolipid metabolism, and inhibition of Nogo-B has protective effects against metabolic syndrome, thus small molecules that inhibit Nogo-B have therapeutic benefits for glycolipid metabolism disorders. In this study we tested 14 flavones/isoflavones in hepatocytes using dual luciferase reporter system based on the Nogo-B transcriptional response system, and found that 6-methyl flavone (6-MF) exerted the strongest inhibition on Nogo-B expression in hepatocytes with an IC50 value of 15.85 mu M. Administration of 6-MF (50 mg.kg(-1).d(-1), i.g. for 3 weeks) significantly improved insulin resistance along with ameliorated liver injury and hypertriglyceridemia in high fructose diet-fed mice. In HepG2 cells cultured in a media containing an FA-fructose mixture, 6-MF (15 mu M) significantly inhibited lipid synthesis, oxidative stress and inflammatory responses. Furthermore, we revealed that 6-MF inhibited Nogo-B/ChREBP-mediated fatty acid synthesis and reduced lipid accumulation in hepatocytes by restoring cellular autophagy and promoting fatty acid oxidation via the AMPKa-mTOR pathway. Thus, 6-MF may serve as a potential Nogo-B inhibitor to treat metabolic syndrome caused by glycolipid metabolism dysregulation.
C1 [Gong, Ke; Zhang, Zhen; Chen, Sha-sha; Zhu, Xin-ran; Wang, Meng-yao; Han, Ji-hong; Li, Qing-shan] Hefei Univ Technol, Key Lab Metab & Regulat Major Dis, Anhui Higher Educ Inst, Hefei 230031, Peoples R China.
   [Yang, Xin-yue; Ding, Chen; Duan, Ya-jun] Univ Sci & Technol China, Affiliated Hosp USTC 1, Dept Cardiol, Div Life Sci & Med, Hefei 230001, Peoples R China.
   [Han, Ji-hong] Nankai Univ, Coll Life Sci, State Key Lab Med Chem Biol, Key Lab Bioact Mat,Minist Educ, Tianjin 300071, Peoples R China.
C3 Hefei University of Technology; Chinese Academy of Sciences; University
   of Science & Technology of China, CAS; Ministry of Education - China;
   Nankai University
RP Li, QS (corresponding author), Hefei Univ Technol, Key Lab Metab & Regulat Major Dis, Anhui Higher Educ Inst, Hefei 230031, Peoples R China.; Duan, YJ (corresponding author), Univ Sci & Technol China, Affiliated Hosp USTC 1, Dept Cardiol, Div Life Sci & Med, Hefei 230001, Peoples R China.
EM liqs@hfut.edu.cn; yajunduan@ustc.edu.cn
RI LI, QS/IED-7767-2023; Duan, Yajun/LJK-9029-2024; Gong, Ke/H-9596-2017;
   Sakura, yoyo/IYJ-3608-2023; ding, chen/KDN-1285-2024
FU China NSFC [U22A20272, 82173807, 81973316]; Tianjin Municipal Science
   and Technology Commission of China [20JCZDJC00710]; Fundamental Research
   Funds for the Central Universities (Nankai University) [63211045]
FX Support was provided by China NSFC grants U22A20272 and~82173807 to YJD,
   81973316 to JHH; Tianjin Municipal Science and Technology Commission of
   China Grant 20JCZDJC00710 and the Fundamental Research Funds for the
   Central Universities (Nankai University) 63211045 to JHH.
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NR 55
TC 6
Z9 6
U1 2
U2 23
PU NATURE PUBL GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1671-4083
EI 1745-7254
J9 ACTA PHARMACOL SIN
JI Acta Pharmacol. Sin.
PD NOV
PY 2023
VL 44
IS 11
BP 2216
EP 2229
AR s41401-023-01121-7
DI 10.1038/s41401-023-01121-7
EA JUL 2023
PG 14
WC Chemistry, Multidisciplinary; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Pharmacology & Pharmacy
GA GW6A4
UT WOS:001025045100003
PM 37402997
OA Green Published
DA 2025-06-11
ER

PT J
AU Asrih, M
   Jornayvaz, FR
AF Asrih, Mohamed
   Jornayvaz, Francois R.
TI Metabolic syndrome and nonalcoholic fatty liver disease: Is insulin
   resistance the link?
SO MOLECULAR AND CELLULAR ENDOCRINOLOGY
LA English
DT Review
DE Metabolic syndrome; NAFLD; Insulin resistance; Ectopic lipids;
   Inflammation
ID GROWTH-FACTOR 21; ENDOPLASMIC-RETICULUM STRESS; INDUCED HEPATIC
   STEATOSIS; ACTIVATED RECEPTOR-ALPHA; NECROSIS-FACTOR-ALPHA; TOLL-LIKE
   RECEPTORS; KINASE-C-EPSILON; ENERGY-EXPENDITURE; ADIPOSE-TISSUE;
   VISCERAL FAT
AB Metabolic syndrome (MetS) is a disease composed of different risk factors such as obesity, type 2 diabetes or dyslipidemia. The prevalence of this syndrome is increasing worldwide in parallel with the rise in obesity. Nonalcoholic fatty liver disease (NAFLD) is now the most frequent chronic liver disease in western countries, affecting more than 30% of the general population. NAFLD encompasses a spectrum of liver manifestations ranging from simple steatosis to nonalcoholic steatohepatitis (NASH), fibrosis and cirrhosis, which may ultimately progress to hepatocellular carcinoma. There is accumulating evidence supporting an association between NAFLD and MetS. Indeed, NAFLD is recognized as the liver manifestation of MetS. Insulin resistance is increasingly recognized as a key factor linking MetS and NAFLD. Insulin resistance is associated with excessive fat accumulation in ectopic tissues, such as the liver, and increased circulating free fatty acids, which can further promote inflammation and endoplasmic reticulum stress. This in turn aggravates and maintains the insulin resistant state, constituting a vicious cycle. Importantly, evidence shows that most of the patients developing NAFLD present at least one of the MetS traits. This review will define MetS and NAFLD, provide an overview of the common pathophysiological mechanisms linking MetS and NAFLD, and give a perspective regarding treatment of these ever growing metabolic diseases. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
C1 [Asrih, Mohamed; Jornayvaz, Francois R.] CHU Vaudois, Serv Endocrinol Diabet & Metab, CH-1011 Lausanne, Switzerland.
C3 University of Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV)
RP Jornayvaz, FR (corresponding author), CHU Vaudois, Serv Endocrinol Diabet & Metab, Rue Bugnon 46, CH-1011 Lausanne, Switzerland.
EM Francois.Jornayvaz@chuv.ch
RI Jornayvaz, François/AAL-2134-2020
OI Jornayvaz, Francois/0000-0001-9425-3137
FU Helmut Horten Foundation; SwissLife
FX This work was supported by the Helmut Horten Foundation and SwissLife.
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NR 154
TC 234
Z9 262
U1 1
U2 50
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0303-7207
J9 MOL CELL ENDOCRINOL
JI Mol. Cell. Endocrinol.
PD DEC 15
PY 2015
VL 418
SI SI
BP 55
EP 65
DI 10.1016/j.mce.2015.02.018
PN 1
PG 11
WC Cell Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Endocrinology & Metabolism
GA DB3AH
UT WOS:000368381400008
PM 25724480
OA Green Published
DA 2025-06-11
ER

PT J
AU Sangaleti, CT
   Katayama, KY
   De Angelis, K
   de Moraes, TL
   Araújo, AA
   Lopes, HF
   Camacho, C
   Bortolotto, LA
   Michelini, LC
   Irigoyen, MC
   Olofsson, PS
   Barnaby, DP
   Tracey, KJ
   Pavlov, VA
   Colombo, FMC
AF Sangaleti, Carine Teles
   Katayama, Keyla Yukari
   De Angelis, Katia
   Lemos de Moraes, Tercio
   Araujo, Amanda Aparecida
   Lopes, Heno F.
   Camacho, Cleber
   Bortolotto, Luiz Aparecido
   Michelini, Lisete Compagno
   Irigoyen, Maria Claudia
   Olofsson, Peder S.
   Barnaby, Douglas P.
   Tracey, Kevin J.
   Pavlov, Valentin A.
   Consolim Colombo, Fernanda Marciano
TI The Cholinergic Drug Galantamine Alleviates Oxidative Stress Alongside
   Anti-inflammatory and Cardio-Metabolic Effects in Subjects With the
   Metabolic Syndrome in a Randomized Trial
SO FRONTIERS IN IMMUNOLOGY
LA English
DT Article
DE metabolic syndrome; galantamine; cholinergic; oxidative stress; heart
   rate variability; autonomic modulation; inflammation
ID INFLAMMATION; OBESITY; HYPERTENSION; DYSFUNCTION; MECHANISMS; PATHWAYS;
   DISEASE; SYSTEM
AB Background: The metabolic syndrome (MetS) is an obesity-associated disorder of pandemic proportions and limited treatment options. Oxidative stress, low-grade inflammation and altered neural autonomic regulation, are important components and drivers of pathogenesis. Galantamine, an acetylcholinesterase inhibitor and a cholinergic drug that is clinically-approved (for Alzheimer's disease) has been implicated in neural cholinergic regulation of inflammation in several conditions characterized with immune and metabolic derangements. Here we examined the effects of galantamine on oxidative stress in parallel with inflammatory and cardio-metabolic parameters in subjects with MetS.
   Trial Design and Methods: The effects of galantamine treatment, 8 mg daily for 4 weeks or placebo, followed by 16 mg daily for 8 weeks or placebo were studied in randomly assigned subjects with MetS (n = 22 per group) of both genders. Oxidative stress, including superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase activities, lipid and protein peroxidation, and nitrite levels were analyzed before and at the end of the treatment. In addition, plasma cytokine and adipokine levels, insulin resistance (HOMA-IR) and other relevant cardio-metabolic indices were analyzed. Autonomic regulation was also examined by heart rate variability (HRV) before treatment, and at every 4 weeks of treatment.
   Results: Galantamine treatment significantly increased antioxidant enzyme activities, including SOD [+1.65 USOD/mg protein, [95% CI 0.39-2.92], P = 0.004] and CAT [+0.93 nmol/mg, [95% CI 0.34-1.51], P = 0.01], decreased lipid peroxidation [thiobarbituric acid reactive substances [log scale 0.72 pmol/mg, [95% CI 0.46-1.07], P = 0.05], and systemic nitrite levels [log scale 0.83 mu mol/mg protein, [95% CI 0.57-1.20], P = 0.04] compared with placebo. In addition, galantamine significantly alleviated the inflammatory state and insulin resistance, and decreased the low frequency/high frequency ratio of HRV, following 8 and 12 weeks of drug treatment.
   Conclusion: Low-dose galantamine alleviates oxidative stress, alongside beneficial anti-inflammatory, and metabolic effects, and modulates neural autonomic regulation in subjects with MetS. These findings are of considerable interest for further studies with the cholinergic drug galantamine to ameliorate MetS.
C1 [Sangaleti, Carine Teles; Bortolotto, Luiz Aparecido; Irigoyen, Maria Claudia; Consolim Colombo, Fernanda Marciano] Univ Sao Paulo, Hypertens Unit, Sao Paulo, Brazil.
   [Sangaleti, Carine Teles] Midwestern State Univ UNICENTRO, Postgrad Program Hlth Sci, Guarapuava, Parana, Brazil.
   [Katayama, Keyla Yukari; De Angelis, Katia; Lemos de Moraes, Tercio; Lopes, Heno F.; Camacho, Cleber; Consolim Colombo, Fernanda Marciano] Nove Julho Univ UNINOVE, Dept Nursing, Grad Program Nanosci & Biosci, Sao Paulo, Brazil.
   [De Angelis, Katia; Araujo, Amanda Aparecida] Fed Univ Sao Paulo UNIFESP, Dept Physiol, Sao Paulo, Brazil.
   [Michelini, Lisete Compagno] Univ Sao Paulo, Biomed Sci Inst, Dept Physiol & Biophys, Sao Paulo, Brazil.
   [Olofsson, Peder S.] Karolinska Inst, Dept Med, Ctr Bioelect Med, Immunobiol Lab, Stockholm, Sweden.
   [Olofsson, Peder S.; Barnaby, Douglas P.; Tracey, Kevin J.; Pavlov, Valentin A.] Northwell Hlth, Feinstein Inst Med Res, Manhasset, NY 11030 USA.
C3 Universidade de Sao Paulo; Universidade Estadual do Centro Oeste;
   Universidade Nove de Julho; Universidade Federal de Sao Paulo (UNIFESP);
   Universidade de Sao Paulo; Karolinska Institutet; Northwell Health
RP Colombo, FMC (corresponding author), Univ Sao Paulo, Hypertens Unit, Sao Paulo, Brazil.; Colombo, FMC (corresponding author), Nove Julho Univ UNINOVE, Dept Nursing, Grad Program Nanosci & Biosci, Sao Paulo, Brazil.; Pavlov, VA (corresponding author), Northwell Hlth, Feinstein Inst Med Res, Manhasset, NY 11030 USA.
EM vpavlov@northwell.edu; fernanda.consolim@uninove.br
RI DE ANGELIS, KATIA/I-6098-2016; Camacho, Cleber/I-8030-2019; Michelini,
   Lisete/C-6485-2012; Barnaby, Douglas/N-3872-2019; Lopes,
   Heno/H-9825-2013; Sangaleti, Carine/AAB-9168-2020; Bortolotto,
   Luiz/S-1940-2017; Irigoyen, maria Claudia/N-6880-2014; Camacho,
   Cleber/C-5220-2014
OI Barnaby, Douglas/0000-0002-2135-0224; Bortolotto,
   Luiz/0000-0002-4865-6442; Pavlov, Valentin/0000-0002-1994-2853;
   Irigoyen, maria Claudia/0000-0003-2097-3662; Michelini,
   Lisete/0000-0003-2978-5406; Camacho, Cleber/0000-0002-8653-0031
FU Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP); Conselho
   Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq); National
   Institutes of Health (NIH) [NIH-NIGMS:R01GM128008, R35GM118182-01]
FX This study was supported by Fundacao de Amparo a Pesquisa do Estado de
   Sao Paulo (FAPESP), Conselho Nacional de Desenvolvimento Cientifico e
   Tecnologico (CNPq), and by the National Institutes of Health (NIH)
   Grants NIH-NIGMS: R01GM128008 to VP, and R35GM118182-01 to KT. The
   funders of this study had no role in study design, data collection, data
   analysis, data interpretation, or manuscript writing. The corresponding
   author had full access to all the data of the study and had the final
   responsibility for the manuscript submission. This manuscript has been
   released as a pre-print at medRxiv (70).
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NR 69
TC 29
Z9 30
U1 1
U2 5
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-3224
J9 FRONT IMMUNOL
JI Front. Immunol.
PD MAR 11
PY 2021
VL 12
AR 613979
DI 10.3389/fimmu.2021.613979
PG 12
WC Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology
GA RB9PH
UT WOS:000632436400001
PM 33776997
OA Green Submitted, gold, Green Published
DA 2025-06-11
ER

PT J
AU Forlico, S
   Baillie, A
   Keys, K
   Woollett, P
   Frydman, G
   Simpson, A
AF Forlico, Sophie
   Baillie, Andrew
   Keys, Kate
   Woollett, Peter
   Frydman, Georgia
   Simpson, Andrew
TI Gym and swim: a co-facilitated exercise program that improves community
   connection, confidence, and exercise habits in a community mental health
   service
SO DISCOVER MENTAL HEALTH
LA English
DT Article
DE Exercise; Physical activity; Severe mental illness; Schizophrenia;
   Psychosis; Physical health; Metabolic disease; Community-based;
   Co-facilitation; Exercise physiology; Peer support; Community
   connection; Social connection
ID MAJOR DEPRESSIVE DISORDER; METABOLIC SYNDROME; BIPOLAR DISORDER;
   SCHIZOPHRENIA; RELIABILITY; PREVALENCE; STATEMENT; ILLNESS; PEOPLE
AB High rates of cardiometabolic disease and poor physical health outcomes contribute to significant premature mortality in people living with severe mental illness (PLWSMI). Lifestyle interventions such as exercise are known to improve both physical and mental health outcomes, however the best way to deliver exercise programs for PLWSMI remains a challenge. This paper uses a pragmatic program evaluation of a co-delivered low-cost community-based exercise program implemented over a 6-month period. Of 46 referrals in the first half of 2023 to the SLHD Gym and Swim program, 13 gave consent to participate in standardised measures and qualitative interviews. Findings revealed an increase in average hours of sport/exercise, improvements in confidence to exercise independently and within group settings, as well as achievement of individualised goals. The success of the program was in part due to the co-facilitation between peer support workers and exercise physiologists, community connection and the established partnership between the public health service and the local government council. Results offer evidence to adopt and implement accessible and low-cost exercise opportunities in the community external to health services to address barriers of attendance for PLWSMI.
C1 [Forlico, Sophie; Keys, Kate; Woollett, Peter; Frydman, Georgia; Simpson, Andrew] Sydney Local Hlth Dist, Mental Hlth Serv, Sydney, Australia.
   [Baillie, Andrew] Sydney Local Hlth Dist, Sydney, Australia.
   [Baillie, Andrew] Univ Sydney, Sydney Sch Hlth Sci, Sydney, Australia.
C3 Sydney Local Health District; Sydney Local Health District; University
   of Sydney
RP Forlico, S (corresponding author), Sydney Local Hlth Dist, Mental Hlth Serv, Sydney, Australia.
EM sophieforlico@gmail.com
RI Baillie, Andrew/A-9154-2008; Simpson, Andrew/HKE-4814-2023
OI Keys, Kate/0009-0007-4194-754X; Baillie, Andrew/0000-0003-3424-5703;
   Woollett, Peter Hayes/0009-0001-5164-2869
FU Health Education Training Institute; Health Education Training Institute
   Mental Health Research Award; Sydney Local Health District; Inner West
   Council (IWC)
FX Sophie Forlico was funded by a Health Education Training Institute
   Mental Health Research Award to complete this research and it was
   supported by Sydney Local Health District. Special thanks go to Stella
   Galanis, Library Manager at Geoff Marel Library, Concord Hospital for
   completing a literature search and for providing ongoing access to
   relevant literature, as well as Hansi Eheliyagoda and Jordan McStraw who
   contributed to the literature review and collection of background
   information. We thank: Renata Tayler and Jemina Isbester who contributed
   to co-design focus group sessions and development of assessment tools;
   Paul La Cava and Raz Akyunare who contributed to co-design focus groups,
   development of assessment tools and data interpretation, as well as
   Linda Persson who contributed to co-design focus groups, development of
   assessment tools, conducting assessments and data interpretation. We
   acknowledge the partnership with the Inner West Council (IWC) for the
   agreement to use their facilities and equipment to deliver Gym and Swim.
   We would like to thank the participants of Gym and Swim who consented to
   take part in this study. An earlier version of this work was presented
   at the 33rd annual Mental Health Services Conference in Adelaide, South
   Australia, 15-18 August 2023. We recognise that preferred terminology in
   mental health care may vary. Throughout this paper, the term consumer is
   used to refer to an individual with lived or living experience of mental
   illness.
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   Wheeler AJ, 2018, HEALTH SOC CARE COMM, V26, P860, DOI 10.1111/hsc.12597
NR 39
TC 0
Z9 0
U1 0
U2 0
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
EI 2731-4383
J9 DISCOV MENT HEALTH
JI Discov. Ment. Heatlh
PD NOV 11
PY 2024
VL 4
IS 1
AR 53
DI 10.1007/s44192-024-00110-4
PG 13
WC Psychiatry
WE Emerging Sources Citation Index (ESCI)
SC Psychiatry
GA L7H1P
UT WOS:001352381400001
PM 39527179
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Blanchard, CM
   Reid, RD
   Morrin, LI
   McDonnell, L
   McGannon, K
   Rhodes, RE
   Spence, JC
   Edwards, N
AF Blanchard, Chris M.
   Reid, Robert D.
   Morrin, Louise I.
   McDonnell, Lisa
   McGannon, Kerry
   Rhodes, Ryan E.
   Spence, John C.
   Edwards, Nancy
TI Demographic and Clinical Determinants of Moderate to Vigorous Physical
   Activity During Home-Based Cardiac Rehabilitation THE HOME-BASED
   DETERMINANTS OF EXERCISE (HOME) STUDY
SO JOURNAL OF CARDIOPULMONARY REHABILITATION AND PREVENTION
LA English
DT Article
DE home-based cardiac rehabilitation; patient characteristics; physical
   activity
ID METABOLIC SYNDROME; CORONARY; PROGRAM; DISEASE
AB PURPOSE: Little is known concerning moderate to vigorous physical activity (MVPA) levels in patients attending home-based cardiac rehabilitation (CR) programs and whether demographic/clinical characteristics moderate these levels.
   METHODS: Patients (N = 280, 77 female) who were referred to home-based CR, mainly because of myocardial infarction (34%), coronary artery bypass graft (17%), and percutaneous coronary intervention/stent/atherectomy (32%), completed a questionnaire assessing demographic and clinical characteristics as well as MVPA, measured at the beginning and end of a 3-month home-based CR program. Charts were reviewed for blood work, blood pressure, stress tests, and diagnosis.
   RESULTS: Patients averaged 88.5 minutes per week of MVPA before starting home-based CR, which increased to 191.1 minutes during the program. Multiple regression analyses showed that patients who were male (beta = -.11), did not have metabolic syndrome (beta = -.14), and were meeting the MVPA guideline before starting home-based CR (beta = .25) engaged in significantly more MVPA during home-based CR than their counterparts. Furthermore, the increase in MVPA was significantly larger for males (beta = -.20), patients without metabolic syndrome (beta = -.13), and patients who did not meet the MVPA guideline at baseline (beta = -.29) than their counterparts.
   CONCLUSIONS: The MVPA levels of patients attending home-based CR tend to vary depending on gender, whether or not metabolic syndrome was present, and prior MVPA levels, suggesting the need to potentially target these particular groups in future behavioral interventions aimed at increasing MVPA.
C1 [Blanchard, Chris M.] Clin Res Ctr, Halifax, NS B3H 1V7, Canada.
   [Reid, Robert D.; McDonnell, Lisa] Ottawa Heart Inst, Minto Prevent & Rehabil Ctr, Ottawa, ON, Canada.
   [Morrin, Louise I.] Calgary Hlth Reg Living Well Chron Condit Program, Calgary, AB, Canada.
   [Rhodes, Ryan E.] Univ Victoria, Fac Educ, Victoria, BC, Canada.
   [Spence, John C.] Univ Alberta, Fac Phys Educ & Recreat, Edmonton, AB, Canada.
   [Edwards, Nancy] Univ Ottawa, Sch Nursing, Ottawa, ON, Canada.
   [McGannon, Kerry] Univ Iowa, Dept Hlth & Sport Studies, Iowa City, IA USA.
C3 Dalhousie University; Dalhousie University Hospital; University of
   Ottawa; University of Ottawa Heart Institute; University of Victoria;
   University of Alberta; University of Ottawa; University of Iowa
RP Blanchard, CM (corresponding author), Clin Res Ctr, Room 205,5790 Univ Ave, Halifax, NS B3H 1V7, Canada.
EM chris.blanchard@dal.ca
RI Spence, John/D-1548-2009; Rhodes, Ryan/ABB-4896-2020; McGannon,
   Kerry/M-2213-2016
OI Spence, John C./0000-0001-8485-1336; Rhodes, Ryan/0000-0003-0940-9040;
   McGannon, Kerry/0000-0002-8614-697X; Edwards, Nancy/0000-0002-3117-5888
FU Social Sciences and Humanities Research Council of Canada; Canada
   Research Chair in Cardiovascular Disease and Physical Activity; CIHR;
   Canadian Health Services Research Foundation; Government of Ontario
FX This project was supported by a standard research grant from the Social
   Sciences and Humanities Research Council of Canada; Dr Blanchard is
   supported by a Canada Research Chair in Cardiovascular Disease and
   Physical Activity; and Dr Rhodes is supported by a CIHR New Investigator
   Award. Dr Edwards holds a Nursing Chair funded by the Canadian Health
   Services Research Foundation, the Canadian Institutes of Health
   Research, and the Government of Ontario.
CR ALLISON PD, 2003, J CARDIOPULM REHABIL, V23, P260
   Arthur HM, 2002, MED SCI SPORT EXER, V34, P1544, DOI 10.1097/00005768-200210000-00003
   Brien SE, 2006, APPL PHYSIOL NUTR ME, V31, P40, DOI 10.1139/H05-024
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   Smith SC, 2006, CIRCULATION, V113, P2363, DOI 10.1161/CIRCULATIONAHA.106.174516
NR 14
TC 36
Z9 38
U1 0
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1932-7501
EI 1932-751X
J9 J CARDIOPULM REHABIL
JI J. Cardiopulm. Rehabil. Prev.
PD JUL-AUG
PY 2010
VL 30
IS 4
BP 240
EP 245
DI 10.1097/HCR.0b013e3181d0c4ae
PG 6
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 626LI
UT WOS:000279967100005
PM 20216322
DA 2025-06-11
ER

PT J
AU Laudisio, A
   Bandinelli, S
   Gemma, A
   Ferrucci, L
   Incalzi, RA
AF Laudisio, Alice
   Bandinelli, Stefania
   Gemma, Antonella
   Ferrucci, Luigi
   Incalzi, Raffaele Antonelli
TI Metabolic syndrome and functional ability in older age: The InCHIANTI
   study
SO CLINICAL NUTRITION
LA English
DT Article
DE Metabolic syndrome; Disability; Elderly; Epidemiology
ID CARDIOVASCULAR RISK-FACTORS; BODY-MASS INDEX; REVERSE EPIDEMIOLOGY;
   HEART-FAILURE; ASSOCIATION; PREVALENCE; DISABILITY; MORTALITY;
   DEPRESSION; DECLINE
AB Background & aims: Metabolic syndrome (MetS) is associated with incident disability in middle-aged subjects. We evaluated the association of MetS with functional ability in an older population.
   Methods: We enrolled 1155 participants aged 65+, derived from the InCHIANTI study, and followed for 3 years. MetS was diagnosed according to the National Cholesterol Education Program's ATP-III criteria. Functional ability was estimated using the Katz's activities of daily living (ADLs), and the Lawton and Brody for the instrumental activities of daily living (IADLs) scales. The association between disability and MetS at baseline and after follow-up was assessed by logistic regression.
   Results: At baseline, MetS was associated with reduced probability of ADLs disability among participants aged 74+ (OR = .33, 95% CI = .14.77; p = .010), but not in younger (5.08, 95% CI = .88-29.24; p = .069). Also, MetS was associated with reduced probability of incident ADLs disability (OR = .61, 95% CI .41-.91; p = .016), but neither with prevalent, nor incident IADLs disability.
   Conclusions: In older persons, MetS is associated with reduced probability of prevalent and incident ADLs disability. Whether older persons with MetS should receive treatment and whether the current diagnostic criteria for MetS apply to older individuals need further investigation. (C) 2013 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.
C1 [Laudisio, Alice; Incalzi, Raffaele Antonelli] Campus Biomed Univ, Area Geriatria, I-00128 Rome, Italy.
   [Bandinelli, Stefania] Azienda Sanit Firenze, Geriatr Rehabil Unit, Florence, Italy.
   [Gemma, Antonella] Azienda Sanit Locale Roma E, UOS Accesso & Presa Car Assistenziale, Rome, Italy.
   [Ferrucci, Luigi] NIA, Longitudinal Studies Sect, Clin Res Branch, Baltimore, MD 21224 USA.
C3 University Campus Bio-Medico - Rome Italy; Azienda Sanitaria di Firenze;
   National Institutes of Health (NIH) - USA; NIH National Institute on
   Aging (NIA)
RP Laudisio, A (corresponding author), Campus Biomed Univ, Area Geriatria, Via Alvaro del Portillo 200, I-00128 Rome, Italy.
EM lavoralice@gmail.com
RI Laudisio, Alice/AHI-1049-2022; Ferrucci, Luigi/AED-9724-2022;
   bandinelli, stefania/AAL-4570-2020; Incalzi, Raffaele/G-3978-2012
OI Ferrucci, Luigi/0000-0002-6273-1613; Laudisio,
   Alice/0000-0002-6167-053X; Antonelli Incalzi,
   Raffaele/0000-0003-2100-2075; Bandinelli, Stefania/0000-0002-6491-0850
FU Italian Ministry of Health [ICS110.1/RF97.71]; U.S. National Institute
   on Aging [263 MD 9164, 263 MD 821336]; InCHIANTI - U.S. National
   Institute on Aging [N.1-AG-1-1, N.1-AG-1-2111]
FX Support: The InCHIANTI study baseline (1998-2000) was supported as a
   targeted project (ICS110.1/RF97.71) by the Italian Ministry of Health
   and in part by the U.S. National Institute on Aging (Contracts 263 MD
   9164 and 263 MD 821336); the InCHIANTI Follow-Up 1 (2001-2003) was
   funded by the U.S. National Institute on Aging (Contracts N.1-AG-1-1 and
   N.1-AG-1-2111).
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NR 30
TC 18
Z9 19
U1 0
U2 4
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0261-5614
EI 1532-1983
J9 CLIN NUTR
JI Clin. Nutr.
PD AUG
PY 2014
VL 33
IS 4
BP 626
EP 633
DI 10.1016/j.clnu.2013.08.005
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA AL0IJ
UT WOS:000338810300009
PM 24035348
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Monteiro, R
   Azevedo, I
AF Monteiro, Rosario
   Azevedo, Isabel
TI Chronic Inflammation in Obesity and the Metabolic Syndrome
SO MEDIATORS OF INFLAMMATION
LA English
DT Review
ID C-REACTIVE PROTEIN; TUMOR-NECROSIS-FACTOR; COMMITTED SUBCUTANEOUS
   PREADIPOCYTES; ADIPOSE-TISSUE; INSULIN-RESISTANCE; WEIGHT-LOSS;
   SUBCLINICAL INFLAMMATION; FAT DISTRIBUTION; GUT MICROBIOTA; ADIPOCYTE
   SIZE
AB The increasing incidence of obesity and the metabolic syndrome is disturbing. The activation of inflammatory pathways, used normally as host defence response, reminds us of the seriousness of this condition. There is most probably more than one cause for the activation of inflammation, a timeline of events related to the deterioration of metabolic homeostasis presenting along variable routes. Apparently, metabolic overload evokes several stress reactions, such as oxidative, inflammatory, organelle, and cell hypertrophy stresses, generating vicious cycles that amplify each other leading to dysfunction. Adipocyte hypertrophy, through purely physical reasons, facilitates cell rupture, what will evoke an inflammatory reaction. Inability of adipose tissue development to engulf all incoming fat leads to fat deposition in other organs, mainly in the liver, with marked consequences on insulin resistance. The oxidative stress which accompanies feeding, particularly when there is an excessive ingestion of fat and/or other macronutrients without concomitant ingestion of antioxidant-rich foods/beverages, may contribute to the inflammatory markers attributed to obesity. Moreover, recent data on the microbiota and its interaction with food and with obesity brought new hypothetic mechanisms for the obesity/fat diet relationship with inflammation. Beyond these common confounders, other phenomena, for instance, psychological and/or circadian rhythm disturbances, may likewise contribute to the raise of oxidative/inflammatory status. The difficulty in the management of the obesity/metabolic syndrome pathologies is linked to their multifactorial nature where environmental, genetic, and psychosocial factors interact through highly complex networks.
C1 [Monteiro, Rosario; Azevedo, Isabel] Univ Porto, Fac Med, Dept Biochem FCT U38, P-4200319 Oporto, Portugal.
C3 Universidade do Porto
RP Monteiro, R (corresponding author), Univ Porto, Fac Med, Dept Biochem FCT U38, Al Prof Hernani Monteiro, P-4200319 Oporto, Portugal.
EM rosariom@med.up.pt
RI Monteiro, Rosário/R-1387-2018
OI Monteiro, Rosario/0000-0003-1552-5507
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NR 116
TC 847
Z9 977
U1 2
U2 69
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 0962-9351
EI 1466-1861
J9 MEDIAT INFLAMM
JI Mediat. Inflamm.
PY 2010
VL 2010
AR 289645
DI 10.1155/2010/289645
PG 10
WC Cell Biology; Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Immunology
GA 640XE
UT WOS:000281086600001
PM 20706689
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Ziegler, MG
   Milic, M
AF Ziegler, Michael G.
   Milic, Milos
TI Sympathetic nerves and hypertension in stress, sleep apnea, and
   caregiving
SO CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION
LA English
DT Review
DE epinephrine; norepinephrine; obesity; psychosocial; sleep
ID ELDERLY ALZHEIMER CAREGIVERS; POSITIVE AIRWAY PRESSURE; RESISTANT
   HYPERTENSION; BLOOD-PRESSURE; CATECHOLAMINERGIC SYSTEMS; HEART-RATE;
   EPINEPHRINE; PLASMA; RISK; INCREASES
AB Purpose of reviewThe sympathetic nervous system (SNS) mediates short-term increases in blood pressure. Evidence that psychosocial stress leads to chronic hypertension is mixed. The SNS activation found in obstructive sleep apnea (OSA), caregiving for a severely demented spouse, and obesity more specifically address whether SNS activation might lead to the metabolic syndrome and hypertension.Recent findingsObesity is associated with both increased SNS electrical activity and plasma norepinephrine. This is partly because of frequent OSA among the obese, but OSA does not fully explain SNS activation in obesity. Large stresses activate adrenal epinephrine release, but both animal and human studies indicate that epinephrine decreases aspects of the metabolic syndrome. On the other hand, norepinephrine is chronically elevated in OSA and among markedly stressed caregivers, and they have an increased incidence of hypertension. This is most striking in OSA, which causes a nocturnal diuresis. Hypertensive patients with OSA are resistant to the antihypertensive effects of diuretics, but respond to drugs that block SNS activity and the effects of renin.SummaryThe SNS may mediate chronic blood pressure increases in response to specific stresses and alter responses to therapy. Evidence linking psychosocial stress to hypertension is mixed.
C1 [Ziegler, Michael G.; Milic, Milos] Univ Calif San Diego, Sch Med, San Diego, CA 92103 USA.
C3 University of California System; University of California San Diego
RP Ziegler, MG (corresponding author), Univ Calif San Diego, Med Ctr, 200 W Arbor Dr, San Diego, CA 92103 USA.
EM mziegler@ucsd.edu
RI Ziegler, Michael/L-4728-2019
FU National Institutes of Health (NIH) [M01RR00827, RF1AG015301,
   UL1TR001442]
FX Funded in part by the National Institutes of Health (NIH) grants
   M01RR00827, RF1AG015301 and UL1TR001442.
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NR 45
TC 18
Z9 20
U1 1
U2 18
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1062-4821
EI 1473-6543
J9 CURR OPIN NEPHROL HY
JI Curr. Opin. Nephrol. Hypertens.
PD JAN
PY 2017
VL 26
IS 1
BP 26
EP 30
DI 10.1097/MNH.0000000000000288
PG 5
WC Urology & Nephrology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Urology & Nephrology; Cardiovascular System & Cardiology
GA EF3QI
UT WOS:000390238900005
PM 27755119
DA 2025-06-11
ER

PT J
AU de Melo, LGP
   Nunes, SOV
   Anderson, G
   Vargas, HO
   Barbosa, DS
   Galecki, P
   Carvalho, AF
   Maes, M
AF Piccoli de Melo, Luiz Gustavo
   Vargas Nunes, Sandra Odebrecht
   Anderson, George
   Vargas, Heber Odebrecht
   Barbosa, Decio Sabbattini
   Galecki, Piotr
   Carvalho, Andre F.
   Maes, Michael
TI Shared metabolic and immune-inflammatory, oxidative and nitrosative
   stress pathways in the metabolic syndrome and mood disorders
SO PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
LA English
DT Review
DE Depressive disorders; Bipolar disorders; Inflammation; Metabolism;
   Oxidative stress; Leaky gut
ID MAJOR DEPRESSIVE DISORDER; NITRIC-OXIDE METABOLITES;
   CORONARY-ARTERY-DISEASE; C-REACTIVE PROTEIN; PLASMA URIC-ACID;
   IO-AND-NS; BIPOLAR-DISORDER; DOUBLE-BLIND; INSULIN-RESISTANCE;
   CARDIOVASCULAR-DISEASE
AB This review examines the shared immune-inflammatory, oxidative and nitrosative stress (IO & NS) and metabolic pathways underpinning metabolic syndrome (MetS), bipolar disorder (BD) and major depressive disorder (MDD). Shared pathways in both MetS and mood disorders are low grade inflammation, including increased levels of pro-inflammatory cytokines and acute phase proteins, increased lipid peroxidation with formation of malondialdehyde and oxidized low density lipoprotein cholesterol (LDL-c), hypernitrosylation, lowered levels of antioxidants, most importantly zinc and paraoxonase (PON1), increased bacterial translocation (leaky gut), increased atherogenic index of plasma and Castelli risk indices; and reduced levels of high-density lipoprotein (HDL-c) cholesterol. Insulin resistance is probably not a major factor associated with mood disorders. Given the high levels of IO & NS and metabolic dysregulation in BD and MDD and the high comorbidity with the atherogenic components of the MetS, mood disorders should be viewed as systemic neuro-IO & NS-metabolic disorders. The IO & NS-metabolic biomarkers may have prognostic value and may contribute to the development of novel treatments targeting neuro-immune, neuro-oxidative and neuro-nitrosative pathways.
C1 [Piccoli de Melo, Luiz Gustavo; Vargas Nunes, Sandra Odebrecht; Vargas, Heber Odebrecht] Londrina State Univ UEL, Dept Clin Med, Hlth Sci Ctr, Londrina, Parana, Brazil.
   [Piccoli de Melo, Luiz Gustavo; Vargas Nunes, Sandra Odebrecht; Vargas, Heber Odebrecht] Univ Estadual Londrina, Univ Hosp, Ctr Approach & Treatment Smokers, Univ Campus, Londrina, Parana, Brazil.
   [Piccoli de Melo, Luiz Gustavo; Vargas Nunes, Sandra Odebrecht; Vargas, Heber Odebrecht; Barbosa, Decio Sabbattini; Maes, Michael] Univ Estadual Londrina, Hlth Sci Ctr, Hlth Sci Grad Program, Londrina, Parana, Brazil.
   [Anderson, George] CRC Scotland & London, London, England.
   [Barbosa, Decio Sabbattini] Univ Estadual Londrina, Dept Clin & Toxicol Anal, Londrina, Parana, Brazil.
   [Galecki, Piotr] Univ Lodz, Dept Adult Psychiat, Lodz, Poland.
   [Carvalho, Andre F.] Univ Fed Ceara, Dept Clin Med, Fac Med, Fortaleza, Ceara, Brazil.
   [Carvalho, Andre F.] Univ Fed Ceara, Translat Psychiat Res Grp, Fac Med, Fortaleza, Ceara, Brazil.
   [Maes, Michael] Chulalongkorn Univ, Dept Psychiat, Bangkok, Thailand.
   [Maes, Michael] Paisij Hilendarski Univ Plovdiv, Dept Psychiat, Plovdiv, Bulgaria.
   [Maes, Michael] Revitalis, Waalre, Netherlands.
   [Maes, Michael] Deakin Univ, Impact Strateg Res Ctr, Geelong, Vic, Australia.
C3 Universidade Estadual de Londrina; Universidade Estadual de Londrina;
   Universidade Estadual de Londrina; Universidade Estadual de Londrina;
   University of Lodz; Universidade Federal do Ceara; Universidade Federal
   do Ceara; Chulalongkorn University; Plovdiv University; Deakin
   University
RP Maes, M (corresponding author), Chulalongkorn Univ, Dept Psychiat, Fac Med, Bangkok, Thailand.
EM dr.michaelmaes@hotmail.com
RI Maes, Michael/B-8546-2011; Carvalho, Andre/AEZ-4001-2022; de Melo, Luiz
   Gustavo Piccoli/C-2271-2018; Barbosa, Décio/AAE-6351-2019; Nunes,
   Sandra/B-4035-2019; Gałecki, Piotr/S-9594-2016; Anderson,
   George/AEO-3626-2022
OI Galecki, Piotr/0000-0003-2447-5636; Anderson,
   George/0000-0001-7243-0817; Maes, Michael/0000-0002-2012-871X; Melo,
   Luiz Gustavo Piccoli de/0000-0002-1078-8044; Odebrecht Vargas Nunes,
   Sandra/0000-0003-4851-6121
FU CNPq [470344/2013-0, 465928/2014-5]; CNPq (level II; Brazil)
FX The authors would like to acknowledge gratefully the Health Sciences
   Postgraduate Program at the State University of Londrina, Brazil. This
   work was supported by CNPq (grants numbers: 470344/2013-0 and
   465928/2014-5). AFC is supported by a research fellowship from CNPq
   (level II; Brazil).
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NR 301
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Z9 134
U1 1
U2 42
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0278-5846
EI 1878-4216
J9 PROG NEURO-PSYCHOPH
JI Prog. Neuro-Psychopharmacol. Biol. Psychiatry
PD AUG 1
PY 2017
VL 78
BP 34
EP 50
DI 10.1016/j.pnpbp.2017.04.027
PG 17
WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA EY9HG
UT WOS:000404309100005
PM 28438472
DA 2025-06-11
ER

PT J
AU Hsu, YT
   Liao, CC
   Chang, SN
   Yang, YW
   Tsai, CH
   Chen, TL
   Sung, FC
AF Hsu, Yi-Ting
   Liao, Chien-Chang
   Chang, Shih-Ni
   Yang, Yu-Wan
   Tsai, Chon-Haw
   Chen, Ta-Liang
   Sung, Fung-Chang
TI Increased Risk of Depression in Patients with Parkinson Disease: A
   Nationwide Cohort Study
SO AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
LA English
DT Article
DE Cohort study; depression; Parkinson disease
ID NEUROPSYCHIATRIC SYMPTOMS; METABOLIC SYNDROME; HEALTH; PREVALENCE;
   INEQUALITIES; HYPOTHESIS; DOPAMINE; REGISTER; DEMENTIA; DISORDER
AB Objective: The association between Parkinson disease (PD) and depression remains unclear, particularly in the Asian population. The purpose of this study is to investigate the risk of depression in patients with PD using population-based data. Methods: Based on the National Health Insurance Research Database of Taiwan, we identified 1,698 patients with PD aged 40 years or older diagnosed in 2000-2003. With frequency matching procedure, we randomly selected 6,792 subjects without PD stratified by sex and age. Both cohorts were followed until the end of 2008 or diagnosis of depression. Risk of depression associated with PD was estimated in the multivariate Cox hazards regressions. Diabetes, hypertension, and hyperlipidemia were more prevalent at baseline in patients with PD. Results: Compared with the cohort without PD, the hazard ratio (HR) for depression in PD patients was 4.06 (95% CI: 3.15-5.23), which increased to 4.26 (95% CI: 3.29-5.51) after adjustment for age, sex, urbanization, income, and coexisting medical conditions. In the sex stratification, the HR of depression for men with PD was 4.42 (95% CI: 2.93-6.67) compared with men without PD. The HR for the association between PD and depression in women was 4.22 (95% CI: 3.02-5.88). Conclusion: This study suggests that patients with PD are at an elevated risk of depression, particularly for men. Integrated care for early identification and treatment of depression are crucial for patients with PD.
C1 [Hsu, Yi-Ting; Yang, Yu-Wan; Tsai, Chon-Haw] China Med Univ Hosp, Neurosci Lab, Dept Neurol, Taichung, Taiwan.
   [Liao, Chien-Chang; Chang, Shih-Ni; Sung, Fung-Chang] China Med Univ Hosp, Management Off Hlth Data, Taichung, Taiwan.
   [Hsu, Yi-Ting; Yang, Yu-Wan; Tsai, Chon-Haw] China Med Univ, Sch Med, Taichung 404, Taiwan.
   [Liao, Chien-Chang] China Med Univ, Sch Chinese Med, Taichung 404, Taiwan.
   [Sung, Fung-Chang] China Med Univ, Dept Publ Hlth, Taichung 404, Taiwan.
   [Liao, Chien-Chang; Chen, Ta-Liang] Taipei Med Univ Hosp, Dept Anesthesiol, Taipei, Taiwan.
   [Liao, Chien-Chang; Chen, Ta-Liang] Taipei Med Univ, Sch Med, Taipei, Taiwan.
C3 China Medical University Taiwan; China Medical University Hospital -
   Taiwan; China Medical University Taiwan; China Medical University
   Hospital - Taiwan; China Medical University Taiwan; China Medical
   University Taiwan; China Medical University Taiwan; Taipei Medical
   University Hospital; Taipei Medical University; Taipei Medical
   University
RP Sung, FC (corresponding author), China Med Univ, Coll Publ Hlth, 91 Hsueh Shih Rd, Taichung 404, Taiwan.
EM fcsung@mail.cmu.edu.tw
RI Chang, Chun-Hung/AAT-1641-2021
OI Hsu, Yi-ting/0000-0002-8552-131X
FU Executive Yuan National Science Council [NSC 99-2314-B-039-016-MY2];
   China Medical University Hospital [DMR-99-176]; Taiwan Ministry of
   Health and Welfare Clinical Trial and Research Center of Excellence
   [MOHW103-TDU-Be212-113002]
FX The study was supported by grants from the Executive Yuan National
   Science Council (NSC 99-2314-B-039-016-MY2), China Medical University
   Hospital (DMR-99-176), and the Taiwan Ministry of Health and Welfare
   Clinical Trial and Research Center of Excellence
   (MOHW103-TDU-Be212-113002). Supporters had no role in study design, data
   collection and analysis, decision to publish, or preparation of the
   article.
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NR 33
TC 32
Z9 35
U1 0
U2 12
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1064-7481
EI 1545-7214
J9 AM J GERIAT PSYCHIAT
JI Am. J. Geriatr. Psychiatr.
PD SEP
PY 2015
VL 23
IS 9
BP 934
EP 940
DI 10.1016/j.jagp.2014.10.011
PG 7
WC Geriatrics & Gerontology; Gerontology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Psychiatry
GA CO8LI
UT WOS:000359420300007
PM 25529799
DA 2025-06-11
ER

PT J
AU Hirano, M
   Imagawa, A
   Totani, K
AF Hirano, Makoto
   Imagawa, Ayami
   Totani, Kiichiro
TI Stratified analysis of lectin-like chaperones in the folding disease
   related metabolic syndrome rat model
SO BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
LA English
DT Article
DE Endoplasmic reticulum; Chaperone; Diabetes mellitus; Obesity; Protein
   interaction; Aggregation
ID ENDOPLASMIC-RETICULUM; QUALITY-CONTROL; DEGRADATION; OBESITY; ERP57
AB The metabolic syndrome including obesity and diabetes mellitus is known to be a major health problem worldwide. A recent study reported that obesity causes endoplasmic reticulum (ER) stress and subsequently leads to insulin resistance and type 2 diabetes. However, little is known about the alterations in the components of the calnexin/calreticulin (CNX/CRT) cycle, which promote glycoprotein folding in obese and diabetic conditions. To understand the operating status of the lectin-like chaperones related to the CNX/CRT cycle in the metabolic syndrome, we analyzed the chaperones for the activity, protein expression, and mRNA expression levels using Zucker fatty (ZF) and Zucker diabetic fatty (ZDF) rat models for obesity and diabetes, respectively. We demonstrated that misfolded proteins were gradually increased with progression of the syndrome, obesity to diabetes. The individual chaperone activities of CNX and CRT were both decreased in the ZF rat ER and, in contrast, were increased in the ZDF rat ER. The protein quantities and mRNA expressions of CNX and CRT were decreased in the ZF rats, but increased in the ZDF rats compared with those of the healthy model. Therefore, these results indicate that obesity down-regulates CNX and CRT expressions and their activities and diabetes up-regulates the expressions and activities of CNX and CRT. Our findings clearly suggest that metabolic syndrome affects the lectin-like chaperones in the CNX/CRT cycle at both the activity and expression levels. (C) 2016 Elsevier Inc. All rights reserved.
C1 [Hirano, Makoto; Imagawa, Ayami; Totani, Kiichiro] Seikei Univ, Dept Mat & Life Sci, 3-3-1 Kichijoji Kita, Musashino, Tokyo 1808633, Japan.
C3 Seikei University
RP Totani, K (corresponding author), Seikei Univ, Dept Mat & Life Sci, 3-3-1 Kichijoji Kita, Musashino, Tokyo 1808633, Japan.
EM ktotani@st.seikei.ac.jp
RI Hirano, Makoto/G-8857-2016
OI Hirano, Makoto/0000-0001-5806-8639
FU Japan Society for the Promotion of Science (JSPS) [JP23681049,
   JP25560420, JP16H06290]; Grants-in-Aid for Scientific Research
   [16H06290] Funding Source: KAKEN
FX This work was financially supported by a Grant-in-Aid for Young
   Scientists (A) (No. JP23681049), a Grant-in-Aid for Challenging
   Exploratory Research (No. JP25560420), and a Grant-in-Aid for Specially
   Promoted Research (No. JP16H06290) from the Japan Society for the
   Promotion of Science (JSPS) to K.T.
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NR 17
TC 5
Z9 6
U1 0
U2 7
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0006-291X
EI 1090-2104
J9 BIOCHEM BIOPH RES CO
JI Biochem. Biophys. Res. Commun.
PD SEP 9
PY 2016
VL 478
IS 1
BP 247
EP 253
DI 10.1016/j.bbrc.2016.07.060
PG 7
WC Biochemistry & Molecular Biology; Biophysics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics
GA DT2TF
UT WOS:000381332800038
PM 27425249
DA 2025-06-11
ER

PT J
AU Galeno, DML
   Carvalho, RP
   Boleti, APD
   Lima, AS
   de Almeida, PDO
   Pacheco, CC
   de Souza, TP
   Lima, ES
AF Lopes Galeno, Denise Morais
   Carvalho, Rosany Piccolotto
   de Araujo Boleti, Ana Paula
   Lima, Arleilson Sousa
   Oliveira de Almeida, Patricia Danielle
   Pacheco, Carolina Carvalho
   de Souza, Tatiane Pereira
   Lima, Emerson Silva
TI Extract from Eugenia punicifolia is an Antioxidant and Inhibits
   Enzymes Related to Metabolic Syndrome
SO APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
LA English
DT Article
DE Eugenia punicifolia; Antioxidant; Digestive enzymes; Metabolic syndrome;
   In vitro assay
ID ALPHA-GLUCOSIDASE; IN-VITRO; OXIDATIVE STRESS; L.
AB The present study aimed to investigate in vitro biological activities of extract of Eugenia punicifolia leaves (EEP), emphasizing the inhibitory activity of enzymes related to metabolic syndrome and its antioxidant effects. The antioxidant activity was analyzed by free radicals scavengers in vitro assays: DPPH center dot, ABTS(center dot+), O-2 (center dot-), and NO center dot and a cell-based assay. EEP were tested in inhibitory colorimetric assays using alpha-amylase, alpha-glucosidase, xanthine oxidase, and pancreatic lipase enzymes. The EEP exhibited activity in ABTS(center dot+), DPPH center dot, and O-2 (center dot-) scavenger (IC50 = 10.5 A +/- 1.2, 28.84 A +/- 0.54, and 38.12 A +/- 2.6 mu g/mL), respectively. EEP did not show cytotoxic effects, and it showed antioxidant activity in cells in a concentration-dependent manner. EEP exhibited inhibition of alpha-amylase, alpha-glucosidase, and xanthine oxidase activities in vitro assays (IC50 = 122.8 A +/- 6.3; 2.9 A +/- 0.1; 23.5 A +/- 2.6), respectively; however, EEP did not inhibit the lipase activity. The findings supported that extract of E. punicifolia leaves is a natural antioxidant and inhibitor of enzymes, such as alpha-amylase, alpha-glucosidase, and xanthine oxidase, which can result in a reduction in the carbohydrate absorption rate and decrease of risks factors of cardiovascular disease, thereby providing a novel dietary opportunity for the prevention of metabolic syndrome.
C1 [de Araujo Boleti, Ana Paula; Lima, Arleilson Sousa; Oliveira de Almeida, Patricia Danielle; Pacheco, Carolina Carvalho; de Souza, Tatiane Pereira; Lima, Emerson Silva] Univ Fed Amazonas, Fac Ciencias Farmaceut, BR-69010300 Manaus, Amazonas, Brazil.
   [Lopes Galeno, Denise Morais; Carvalho, Rosany Piccolotto] Univ Fed Amazonas, Dept Ciencias Fisiol, Inst Ciencias Biol, Lab Fisiol, BR-69010300 Manaus, Amazonas, Brazil.
C3 Universidade Federal de Amazonas; Universidade Federal de Amazonas
RP Lima, ES (corresponding author), Univ Fed Amazonas, Fac Ciencias Farmaceut, Rua Alexandre Amorim 330, BR-69010300 Manaus, Amazonas, Brazil.
EM morais_denise@hotmail.com; eslima@ufam.edu.br
RI Almeida, Patricia/MBV-8173-2025; de Souza, Tatiane/AAL-8078-2021; Silva
   Lima, Emerson/L-4553-2016; Araujo Boleti, Ana Paula/F-3433-2019
OI Silva Lima, Emerson/0000-0002-9367-2812; Araujo Boleti, Ana
   Paula/0000-0003-0253-8907; Galeno, Denise/0000-0001-8265-8698; Oliveira
   de Almeida, Patricia Danielle/0000-0002-2620-8251
FU Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq);
   Fundacao de Amparo a Pesquisa do Estado do Amazonas (FAPEAM);
   DCR/CNPq/FAPEAM
FX The authors are grateful to Conselho Nacional de Desenvolvimento
   Cientifico e Tecnologico (CNPq) and Fundacao de Amparo a Pesquisa do
   Estado do Amazonas (FAPEAM) for the financial support of this research.
   ESL is member of the INCT of Processes Redox in Biomedicina-Redoxoma
   (MCT/CNPq). APAB received a grant from DCR/CNPq/FAPEAM. Thanks to Celio
   Maia Chaves from EMBRAPA for the Eugenia punicifolia plant material
   donation and to Jim Hesson of AcademicEnglishSolutions.com for
   proofreading the English.
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NR 36
TC 27
Z9 28
U1 0
U2 21
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0273-2289
EI 1559-0291
J9 APPL BIOCHEM BIOTECH
JI Appl. Biochem. Biotechnol.
PD JAN
PY 2014
VL 172
IS 1
BP 311
EP 324
DI 10.1007/s12010-013-0520-8
PG 14
WC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology
GA AA3PQ
UT WOS:000331005200027
PM 24078187
DA 2025-06-11
ER

PT J
AU El-Fawal, R
   El Fayoumi, HM
   Mahmoud, MF
AF El-Fawal, Rania
   El Fayoumi, Hassan M.
   Mahmoud, Mona F.
TI Effects of diosmin and crocin on metabolic syndrome-associated
   cardio-vascular complications in rats
SO NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
LA English
DT Article
DE Diosmin; Crocin; Metabolic syndrome; Vascular reactivity; Inflammation;
   ECG
ID GLYCATION END-PRODUCTS; OXIDATIVE STRESS; INSULIN-RESISTANCE;
   ENDOTHELIAL DYSFUNCTION; ALLEVIATES HYPERTENSION; DOWN-REGULATION;
   SATIVUS L.; MODEL; INHIBITION; ANTIOXIDANT
AB This study aims to scrutinize the potential protective effect of diosmin and crocin against cardio-vascular complications attributed to metabolic syndrome (MS). For 16 weeks, the rats were given 10% fructose in water and 3% salt in diet to induce MS over a 16-week period. At week 7 and for 10 weeks, diosmin (50 mg/kg, PO) or crocin (50 mg/kg, PO) was administered daily. Non-invasive blood pressure (BP) was recorded in conscious animals. Thoracic aorta (macro vessels) and kidney (micro vessels) concentration-response curves for phenylephrine (PE) and acetylcholine (ACh) were analyzed. Electrocardiogram (ECG) parameters were recorded. Blood glucose level, serum insulin level, troponin T, advanced glycation end products (AGEs), malondialdehyde (MDA), and tumor necrosis factor-alpha (TNF-alpha) were measured. In addition, histological examination of aorta and heart tissues was performed. Diosmin and crocin alleviated cardio-vascular complications associated with MS. This is manifested in improvement of systolic and diastolic BP and ECG parameters. They ameliorated MS-induced exaggerated contractility to PE and improved the impaired dilatation to Ach in macro and micro vasculature. Diosmin and crocin reduced the elevated serum levels of insulin, AGEs, TNF-alpha, and MDA and reversed MS-induced structural changes of aorta and cardiac tissues. Diosmin and crocin offset the cardiac changes and vascular impairment associated with MS via attenuation of oxidative stress and suppression of inflammation.
C1 [El-Fawal, Rania; El Fayoumi, Hassan M.; Mahmoud, Mona F.] Zagazig Univ, Fac Pharm, Dept Pharmacol & Toxicol, Zagazig 44519, Egypt.
   [El Fayoumi, Hassan M.] Sinai Univ Qantara, Fac Pharm, El Arish El Masaid, Egypt.
C3 Egyptian Knowledge Bank (EKB); Zagazig University; Egyptian Knowledge
   Bank (EKB); Sinai University
RP Mahmoud, MF (corresponding author), Zagazig Univ, Fac Pharm, Dept Pharmacol & Toxicol, Zagazig 44519, Egypt.
EM Mona_pharmacology@yahoo.com
RI Mahmoud, Mona/Q-8851-2019
OI Mahmoud, Mona/0000-0002-5312-2066
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NR 65
TC 10
Z9 11
U1 0
U2 11
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0028-1298
EI 1432-1912
J9 N-S ARCH PHARMACOL
JI Naunyn-Schmiedebergs Arch. Pharmacol.
PD DEC
PY 2019
VL 392
IS 12
BP 1523
EP 1536
DI 10.1007/s00210-019-01700-8
PG 14
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA JL8UB
UT WOS:000495801700005
PM 31352499
DA 2025-06-11
ER

PT J
AU Fraga, MC
   de Moura, EG
   Lima, ND
   Lisboa, PC
   de Oliveira, E
   Silva, JO
   Claudio-Neto, S
   Filgueiras, CC
   Abreu-Villaça, Y
   Manhaes, AC
AF Fraga, Mabel Carneiro
   de Moura, Egberto Gaspar
   Lima, Natalia da Silva
   Lisboa, Patricia C.
   de Oliveira, Elaine
   Silva, Juliana Oliveira
   Claudio-Neto, Sylvio
   Filgueiras, Claudio C.
   Abreu-Villaca, Yael
   Manhaes, Alex C.
TI Anxiety-like, novelty-seeking and memory/learning behavioral traits in
   male Wistar rats submitted to early weaning
SO PHYSIOLOGY & BEHAVIOR
LA English
DT Article
DE Early weaning; Anxiety; Novelty-seeking; Memory; Learning; Motor
   activity
ID ELEVATED PLUS-MAZE; MATERNAL PROLACTIN INHIBITION; LACTATION PROGRAMS;
   BODY-WEIGHT; CORTICOSTERONE RESPONSES; DEVELOPMENTAL PLASTICITY;
   NICOTINE CONSUMPTION; METABOLIC SYNDROME; LEPTIN RESISTANCE;
   SOCIAL-ISOLATION
AB The most frequently used animal models of early weaning (EW) in rodents, maternal deprivation and pharmacological inhibition of lactation, present confounding factors, such as high stress or drug side effects, that can mask or interact with the effects of milk deprivation per se. Given these limitations, the development of new models of EW may provide useful information regarding the impact of a shortened period of breastfeeding on the endocrine and nervous systems, both during development and at adulthood. Using a model of EW in which lactating Wistar rat dams are wrapped with a bandage to block access to milk during the last three days of lactation, we have recently shown that the adult offspring presented higher body mass, hyperphagia, hyperleptinemia, leptin as well as insulin resistance, and higher adrenal catecholamine content at adulthood. Here, we used this EW model, which involves no pharmacological treatment or maternal separation, to analyze anxiety-like, novelty-seeking and memory/learning behavioral traits in the adult male offspring. To that end, animals were tested in the elevated plus maze, in the hole board arena and in the radial arm water maze. Except for an increased number of rearing events (a measure of vertical activity), no other behavioral differences were observed between EW and control animals. The contrasting behavioral results between the three EW models may be associated with differences in HPA axis function in the offspring at weaning, since it has been observed that bandaging does not affect corticosteronemia while maternal separation and pharmacological EW increase it. (C) 2013 Elsevier Inc. All rights reserved.
C1 [Fraga, Mabel Carneiro; Silva, Juliana Oliveira; Claudio-Neto, Sylvio; Filgueiras, Claudio C.; Abreu-Villaca, Yael; Manhaes, Alex C.] Univ Estado Rio de Janeiro, Inst Biol Roberto Alcantara Gomes, Dept Ciencias Fisiol, Ctr Biomed,Lab Neurofisiol, BR-20550170 Rio De Janeiro, RJ, Brazil.
   [Fraga, Mabel Carneiro; de Moura, Egberto Gaspar; Lima, Natalia da Silva; Lisboa, Patricia C.; de Oliveira, Elaine] Univ Estado Rio de Janeiro, Inst Biol Roberto Alcantara Gomes, Dept Ciencias Fisiol, Ctr Biomed,Lab Fisiol Endocrina, BR-20550170 Rio De Janeiro, RJ, Brazil.
C3 Universidade do Estado do Rio de Janeiro; Universidade do Estado do Rio
   de Janeiro
RP Manhaes, AC (corresponding author), Univ Estado Rio de Janeiro, Inst Biol Roberto Alcantara Gomes, Dept Ciencias Fisiol, Ctr Biomed,Lab Neurofisiol, Av Prof Manuel de Abreu 444,5 Andar, BR-20550170 Rio De Janeiro, RJ, Brazil.
EM amanhaes@uerj.br
RI Filgueiras, Claudio/MBG-9894-2025; Manhães, Alex/F-5499-2011;
   Abreu-Villaca, Yael/D-5997-2015; Neto, Sylvio/AAD-7517-2021; LIMA,
   NATALIA/K-5674-2015; Lisboa, Patricia/H-8336-2015; Moura,
   Egberto/H-1270-2012
OI Claudio Neto, Sylvio/0000-0002-2155-5983; Lisboa,
   Patricia/0000-0002-2477-4364; Abreu-Villaca, Yael/0000-0002-9801-6179;
   Manhaes, Alex C./0000-0003-4629-8343; Filgueiras,
   Claudio/0000-0003-4522-4799; Moura, Egberto/0000-0002-1159-7549
FU Fundacao Carlos Chagas Filho de Amparo a Pesquisa do Estado do Rio de
   Janeiro (FAPERJ); Conselho Nacional de Desenvolvimento Cientifico e
   Tecnologico (CNPq); Sub-reitoria de Pos-graduacao e Pesquisa da
   Universidade do Estado do Rio de Janeiro (SR2-UERJ); Coordenacao de
   Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
FX This work was supported by grants from: Fundacao Carlos Chagas Filho de
   Amparo a Pesquisa do Estado do Rio de Janeiro (FAPERJ), Conselho
   Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) and
   Sub-reitoria de Pos-graduacao e Pesquisa da Universidade do Estado do
   Rio de Janeiro (SR2-UERJ). Authors ACM, CCF, EGM, PCB and YAV received
   fellowships from CNPq. Author MCF received a fellowship from FAPERJ.
   Authors NSL, JOS and SCN received scholarships from CNPq. Author SCN
   received a scholarship from Coordenacao de Aperfeicoamento de Pessoal de
   Nivel Superior (CAPES).
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NR 90
TC 16
Z9 18
U1 0
U2 20
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0031-9384
J9 PHYSIOL BEHAV
JI Physiol. Behav.
PD JAN 30
PY 2014
VL 124
BP 100
EP 106
DI 10.1016/j.physbeh.2013.11.001
PG 7
WC Psychology, Biological; Behavioral Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Behavioral Sciences
GA AB0LA
UT WOS:000331482200014
PM 24246723
OA hybrid
DA 2025-06-11
ER

PT J
AU Murat, M
   Kutlu, Y
AF Murat, Merve
   Kutlu, Yasemin
TI Turkish Adaptation of the Health Improvement Profile for the Evaluation
   of Physical Well-Being of Individuals With Severe Mental Illness
SO FLORENCE NIGHTINGALE JOURNAL OF NURSING
LA English
DT Article
DE health promotion; physical examination; psychiatric nursing; severe
   mental disorders
ID MAJOR DEPRESSIVE DISORDER; BIPOLAR DISORDER; METABOLIC SYNDROME;
   SCHIZOPHRENIA; PEOPLE; ASSOCIATION; PREVALENCE; MORTALITY; BEHAVIOR;
   DIETARY
AB AIM: This study aimed to adopt the use of the Health Improvement Profile in the Turkish context and to report the findings obtained during its pilot implementation. METHODS: This descriptive cross-sectional study consisted of 280 individuals, and data were collected using the Patient and Disease Characteristics Form and the Health Improvement Profile between May and December 2019 & imath;n community mental health centers. The total content validity index of the Health Improvement Profile (Female-Male) was 0.97. RESULTS: Among the participants, 57.1% had a physical health problem, 58.1% had a diagnosis of a physical condition, and 41.9% had physical symptoms only. Intergroup comparisons showed that individuals diagnosed with schizophrenia and other psychotic disorders slept for less than 3 hours, individuals diagnosed with bipolar disorder consumed more alcohol, and individuals diagnosed with major depressive disorders slept for more than 8 hours, smoked more, consumed more caffeine, and practiced safe sex less consistently than individuals diagnosed with other psychiatric disorders (p < .05). CONCLUSION: The Health Improvement Profile is an assessment tool that psychiatric mental health nurses can use to evaluate the physical health of individuals diagnosed with serious mental illness. The use of Health Improvement Profile in routine practice may allow determining the redflagged parameters and provide an opportunity improving these parameters with evidence-based interventions.
C1 [Murat, Merve] Istanbul Univ Cerrahpasa, Inst Grad Studies, Istanbul, Turkiye.
   [Kutlu, Yasemin] Istanbul Univ Cerrahpasa, Florence Nightingale Fac Nursing, Dept Mental Hlth & Psychiat Nursing, Istanbul, Turkiye.
C3 Istanbul University - Cerrahpasa; Istanbul University - Cerrahpasa
RP Murat, M (corresponding author), Istanbul Univ Cerrahpasa, Inst Grad Studies, Istanbul, Turkiye.
EM murat.merve@yahoo.com
RI Kutlu, Yasemin/Q-6107-2017; MURAT MEHMED ALİ, MERVE/Q-8703-2018
FX Funding: The authors declared that this study has received no financial
   support.
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NR 55
TC 0
Z9 0
U1 0
U2 0
PU AVES
PI SISLI
PA BUYUKDERE CAD 105-9, MECIDIYEKOY, SISLI, ISTANBUL 34394, Turkiye
SN 2687-6442
J9 FLOR NIGHT J NURS
JI Florence Nightingale J. Nurs.
PD JUN
PY 2024
VL 32
IS 2
BP 168
EP 183
DI 10.5152/FNJN.2024.23085
PG 16
WC Nursing
WE Emerging Sources Citation Index (ESCI)
SC Nursing
GA XE7S2
UT WOS:001260078800008
PM 39552166
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Bressington, D
   Badnapurkar, A
   Inoue, S
   Ma, HY
   Chien, WT
   Nelson, D
   Gray, R
AF Bressington, Daniel
   Badnapurkar, Ashish
   Inoue, Sachiko
   Ma, Hin Yeung
   Chien, Wai Tong
   Nelson, Deborah
   Gray, Richard
TI Physical Health Care for People with Severe Mental Illness: the
   Attitudes, Practices, and Training Needs of Nurses in Three Asian
   Countries
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Article
DE nurse attitudes; physical health care; severe mental illness; nurse
   education
ID METABOLIC SYNDROME; NURSING-STUDENTS; DISORDERS; SCHIZOPHRENIA;
   MORTALITY; KNOWLEDGE; RISK; PERCEPTIONS; DISPARITIES; QUALITY
AB People with severe mental illness (SMI) have considerable unmet physical health needs and an increased risk of early mortality. This cross-sectional survey utilized the Physical Health Attitude Scale (PHASe) to examine the attitudes, practices, and training needs of nurses towards physical health care of people with SMI in three Asian countries (Hong Kong, Japan, Qatar). Cross-country differences were explored and linear regression was used to investigate if nurses' attitudes and confidence were associated with their level of involvement in physical health care. A total of 481 questionnaires were returned. Hong Kong nurses were less involved in physical health care than those from Japan and Qatar. Nurses' attitudes and confidence were significant predictors of their participation in managing physical health. Compared with western countries, more nurses in this study felt that mental illness was a barrier to improving physical health. Three-quarters reported that they needed additional training in promoting cardiometabolic health. The perceived need for additional training in physical health care was held by Mental Health Nurses (MHN) irrespective of their type of nursing registration and nationality. Nurse educators and service providers should reconsider the physical health care training requirements of nurses working in mental health settings in order to improve the physical health of people with SMI.
C1 [Bressington, Daniel; Ma, Hin Yeung; Chien, Wai Tong] Hong Kong Polytech Univ, Sch Nursing, Kowloon, Hong Kong, Peoples R China.
   [Badnapurkar, Ashish] Hamad Med Corp, Hlth Serv & Populat Res Ctr, POB 3050, Doha, Qatar.
   [Inoue, Sachiko] Okayama Prefectural Univ, Dept Nursing, 111 Kuboki, Okayama 7191197, Japan.
   [Nelson, Deborah] Hamad Med Corp, Mental Hlth Serv, POB 3050, Doha, Qatar.
   [Gray, Richard] La Trobe Univ, Dept Nursing & Midwifery, Melbourne, Vic 3086, Australia.
C3 Hong Kong Polytechnic University; Hamad Medical Corporation; Okayama
   Prefectural University; Hamad Medical Corporation; La Trobe University
RP Bressington, D (corresponding author), Hong Kong Polytech Univ, Sch Nursing, Kowloon, Hong Kong, Peoples R China.
EM dan.bressington@polyu.edu.hk; ABadanapurkar@hamad.qa;
   sinoue@fhw.oka-pu.ac.jp; hin-yeung.ma@connect.polyu.hk;
   wai.tong.chien@polyu.edu.hk; DNelson@hamad.qa; r.gray@latrobe.edu.au
RI Chien, Wai Tong/M-6106-2019; Badanapurkar, Ashishkumar/AAW-7043-2020;
   Gray, Richard/C-9945-2017; Bressington, Daniel/G-2789-2017; Chien, Wai
   Tong/F-9604-2014
OI Badanapurkar, Ashishkumar/0000-0002-4668-2532; Gray,
   Richard/0000-0001-9694-4206; Inoue, Sachiko/0000-0003-1840-5631;
   Bressington, Daniel/0000-0003-0951-2208; Chien, Wai
   Tong/0000-0001-5321-5791
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NR 37
TC 35
Z9 38
U1 0
U2 9
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD FEB
PY 2018
VL 15
IS 2
AR 343
DI 10.3390/ijerph15020343
PG 14
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA FY3LM
UT WOS:000426721400168
PM 29462859
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Coole, JB
   Burr, SS
   Kay, AM
   Singh, JA
   Kondakala, S
   Yang, EJ
   Kaplan, BLF
   Howell, GE
   Stewart, JA
AF Coole, Jackson B.
   Burr, Stephanie S.
   Kay, Amber M.
   Singh, Jaime A.
   Kondakala, Sandeep
   Yang, Eun-Ju
   Kaplan, Barbara L. F.
   Howell, George E., III
   Stewart, James A., Jr.
TI Persistent organic pollutants (POPs) increase rage signaling to promote
   downstream cardiovascular remodeling
SO ENVIRONMENTAL TOXICOLOGY
LA English
DT Article
DE AGE-RAGE signaling; heart; oxidative stress; persistent organic
   pollutants; type 2 diabetes mellitus
ID GLYCATION END-PRODUCTS; MANGANESE SUPEROXIDE-DISMUTASE; METABOLIC
   SYNDROME; RECEPTOR; EXPOSURE; COLLAGEN; ACCUMULATION; EXPRESSION;
   LEPTIN; CELLS
AB Exposure to environmental contaminants and consumption of a high, saturated fatty diet has been demonstrated to promote precursors for metabolic syndrome (hyperglycemia, hyperinsulinemia, and hypertriglyceridemia). The purpose of this study was to determine if exposure to the most prevalent environmental persistent organic pollutants (POPs) would act as causative agents to promote metabolic syndrome independent of dietary intake. We hypothesized that POPs will activate the advanced glycated end-product (AGE)-and receptor for AGE (RAGE) signaling cascade to promote downstream signaling modulators of cardiovascular remodeling and oxidative stress in the heart. At 5-weeks of age nondiabetic (WT) and diabetic (ob/ob) mice were exposed POPs mixtures by oral gavage twice a week for 6-weeks. At the end of 6-weeks, animals were sacrificed and the hearts were taken for biochemical analysis. Increased activation of the AGE-RAGE signaling cascade via POPs exposure resulted in elevated levels of fibroblast differentiation (alpha-smooth muscle actin) and RAGE expression indicated maladaptive cardiac remodeling. Conversely, the observed decreased superoxide dismutase-1 and -2 (SOD-1 and SOD-2) expression may exacerbate the adverse changes occurring as a result of POPs treatment to reduce innate cardioprotective mechanisms. In comparison, ventricular collagen levels were decreased in mice exposed to POPs. In conclusion, exposure to organic environmental pollutants may intensify oxidative and inflammatory stressors to overwhelm protective mechanisms allowing for adverse cardiac remodeling.
C1 [Coole, Jackson B.] Mississippi State Univ, Coll Arts & Sci, Dept Biol Sci, Starkville, MS USA.
   [Burr, Stephanie S.; Kay, Amber M.; Stewart, James A., Jr.] Univ Mississippi, Sch Pharm, Dept Biomol Sci, Oxford, MS USA.
   [Singh, Jaime A.] Virginia Commonwealth Univ Hlth Syst, Richmond, VA USA.
   [Kondakala, Sandeep; Yang, Eun-Ju; Kaplan, Barbara L. F.; Howell, George E., III] Mississippi State Univ, Dept Basic Sci, Coll Vet Med, Starkville, MS USA.
C3 Mississippi State University; University of Mississippi; Virginia
   Commonwealth University; Mississippi State University
RP Stewart, JA (corresponding author), Univ Mississippi, Sch Pharm, Dept Biomol Sci, University, MS 38677 USA.
EM jastewa7@olemiss.edu
RI Kondakala, Sandeep/HGU-4505-2022
OI Kondakala, Sandeep/0000-0003-3958-7104; Coole,
   Jackson/0000-0002-8821-4139; Kaplan, Barbara/0000-0002-1992-4145
FU Mississippi State University Department of Biological Sciences;
   Mississippi State University Shackoul's Honors College; Office of
   Research and Graduate Studies at the Mississippi State University
   College of Veterinary Medicine; University of Mississippi School of
   Pharmacy; Department of BioMolecular Sciences
FX Mississippi State University Department of Biological Sciences;
   Mississippi State University Shackoul's Honors College; Office of
   Research and Graduate Studies at the Mississippi State University
   College of Veterinary Medicine; University of Mississippi School of
   Pharmacy; Department of BioMolecular Sciences
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NR 49
TC 7
Z9 7
U1 2
U2 16
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1520-4081
EI 1522-7278
J9 ENVIRON TOXICOL
JI Environ. Toxicol.
PD OCT
PY 2019
VL 34
IS 10
BP 1149
EP 1159
DI 10.1002/tox.22817
EA JUL 2019
PG 11
WC Environmental Sciences; Toxicology; Water Resources
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Toxicology; Water Resources
GA JU6XI
UT WOS:000476063100001
PM 31313498
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Hu, RA
   Geng, YL
   Huang, YJ
   Liu, Z
   Li, F
   Dong, HX
   Ma, WW
   Song, KK
   Zhang, MM
   Zhang, Z
   Song, YF
AF Hu, Runan
   Geng, Yuli
   Huang, Yanjing
   Liu, Zhuo
   Li, Fan
   Dong, Haoxu
   Ma, Wenwen
   Song, Kunkun
   Zhang, Mingmin
   Zhang, Zhuo
   Song, Yufan
TI New insights into the interaction between polycystic ovary syndrome and
   psychiatric disorders: A narrative review
SO INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
LA English
DT Review
DE gut dysbiosis; hormonal disturbances; insulin resistance; interaction;
   obesity; polycystic ovary syndrome; psychiatric disorders
ID QUALITY-OF-LIFE; POPULATION-BASED COHORT; INSULIN-RESISTANCE;
   MENTAL-HEALTH; BIPOLAR DISORDER; CONTROLLED-TRIAL; INCREASED RISK;
   DEPRESSIVE-DISORDERS; PSYCHOLOGICAL BURDEN; METABOLIC SYNDROME
AB Polycystic ovary syndrome (PCOS) is a prevalent endocrine disease characterized by hyperandrogenism, ovulatory dysfunction, and ovarian polycystic changes, which combines with reproductive problems, metabolic disorders, and psychological disorders to exhibit a far-reaching impact on the physical and mental health of women. We reviewed previous research and discovered that psychiatric disorders are more common in PCOS patients and their children, potentially exacerbating the condition and creating a vicious loop. To understand the reasons, relevant articles were collected following the Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines from PubMed, Web of Science, and Cochrane Library, through December 2022. Evidence suggested that PCOS-related clinical manifestations, hyperandrogenism, insulin resistance, obesity, gut dysbiosis, and other variables may increase the risk of psychiatric disorders in patients. In turn, psychiatric disorders may aggravate the pathologic process of PCOS and increase the difficulty of the treatment. We systematically reported the mechanisms underlying the psychiatric disorders-PCOS interactions, intending to provide potential ways to break the vicious cycle and lay the groundwork for future research. However, research on PCOS and psychiatric disorders were still in initial stages, which limited the scope of this review. More studies are needed to further verify our findings.
C1 [Hu, Runan; Geng, Yuli; Huang, Yanjing; Liu, Zhuo; Li, Fan; Song, Yufan] Huazhong Univ Sci & Technol, Tongji Hosp, Inst Integrated Tradit Chinese & Western Med, Tongji Med Coll, Wuhan, Peoples R China.
   [Dong, Haoxu; Ma, Wenwen; Song, Kunkun; Zhang, Mingmin; Song, Yufan] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Integrated Tradit Chinese & Western Med, Wuhan, Peoples R China.
   [Zhang, Zhuo] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Neurosurg, Wuhan, Peoples R China.
   [Song, Yufan] Huazhong Univ Sci & Technol, Tongji Hosp, Inst Integrated Tradit Chinese & Western Med, Tongji Med Coll, 13 Jiefang Ave, Wuhan 430030, Peoples R China.
   [Zhang, Zhuo] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Neurosurg, Wuhan 430030, Peoples R China.
C3 Huazhong University of Science & Technology; Huazhong University of
   Science & Technology; Huazhong University of Science & Technology;
   Huazhong University of Science & Technology; Huazhong University of
   Science & Technology
RP Song, YF (corresponding author), Huazhong Univ Sci & Technol, Tongji Hosp, Inst Integrated Tradit Chinese & Western Med, Tongji Med Coll, 13 Jiefang Ave, Wuhan 430030, Peoples R China.; Zhang, Z (corresponding author), Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Neurosurg, Wuhan 430030, Peoples R China.
EM zhzmclaren@gmail.com; songyufan23@163.com
RI Zhang, Mingmin/HTS-1310-2023
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NR 205
TC 5
Z9 6
U1 1
U2 16
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0020-7292
EI 1879-3479
J9 INT J GYNECOL OBSTET
JI Int. J. Gynecol. Obstet.
PD FEB
PY 2024
VL 164
IS 2
BP 387
EP 420
DI 10.1002/ijgo.14988
EA JUL 2023
PG 34
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA FA4T0
UT WOS:001026578500001
PM 37458179
OA Bronze
DA 2025-06-11
ER

PT J
AU Kondo, T
   Miyakawa, N
   Kitano, S
   Watanabe, T
   Goto, R
   Suico, MA
   Sato, M
   Takaki, Y
   Sakaguchi, M
   Igata, M
   Kawashima, J
   Motoshima, H
   Matsumura, T
   Kai, H
   Araki, E
AF Kondo, Tatsuya
   Miyakawa, Nobukazu
   Kitano, Sayaka
   Watanabe, Takuro
   Goto, Rieko
   Suico, Mary Ann
   Sato, Miki
   Takaki, Yuki
   Sakaguchi, Masaji
   Igata, Motoyuki
   Kawashima, Junji
   Motoshima, Hiroyuki
   Matsumura, Takeshi
   Kai, Hirofumi
   Araki, Eiichi
TI Activation of heat shock response improves biomarkers of NAFLD in
   patients with metabolic diseases
SO ENDOCRINE CONNECTIONS
LA English
DT Article
DE heat shock response (HSR); type 2 diabetes (T2DM); nonalcoholic fatty
   liver disease (NAFLD); endoplasmic reticulum (ER) stress
ID FATTY LIVER-DISEASE; ENDOPLASMIC-RETICULUM STRESS; MILD
   ELECTRICAL-STIMULATION; VISCERAL ADIPOSITY; HEPATIC STEATOSIS;
   INSULIN-RESISTANCE; INDEX; HSP72; EXPRESSION; PROTECTS
AB Nonalcoholic fatty liver disease (NAFLD) is often accompanied by metabolic disorders such as metabolic syndrome and type 2 diabetes (T2DM). Heat shock response (HSR) is one of the most important homeostatic abilities but is deteriorated by chronic metabolic insults. Heat shock (HS) with an appropriate mild electrical stimulation (MES) activates HSR and improves metabolic abnormalities including insulin resistance, hyperglycemia and inflammation in metabolic disorders. To analyze the effects of HS + MES treatment on NAFLD biomarkers, three cohorts including healthy men (two times/week, n = 10), patients with metabolic syndrome (four times/week, n = 40), and patients with T2DM (n = 100; four times/week (n = 40) and two, four, seven times/week (n = 20 each)) treated with HS + MES were retrospectively analyzed. The healthy subjects showed no significant alterations in NAFLD biomarkers after the treatment. In patients with metabolic syndrome, many of the NAFLD steatosis markers, including fatty liver index, NAFLD-liver fat score, liver/spleen ratio and hepatic steatosis index and NAFLD fibrosis marker, aspartate aminotransferase/ alanine aminotransferase (AST/ALT) ratio, were improved upon the treatment. In patients with T2DM, all investigated NAFLD steatosis markers were improved and NAFLD fibrosis markers such as the AST/ALT ratio, fibrosis-4 index and NAFLD-fibrosis score were improved upon the treatment. Thus, HS + MES, a physical intervention, may become a novel treatment strategy for NAFLD as well as metabolic disorders.
C1 [Kondo, Tatsuya; Kitano, Sayaka; Igata, Motoyuki] Kumamoto Univ Hosp, Dept Diabet Metab & Endocrinol, Chuo Ward, Kumamoto, Japan.
   [Miyakawa, Nobukazu; Watanabe, Takuro; Goto, Rieko; Sato, Miki; Takaki, Yuki; Sakaguchi, Masaji; Kawashima, Junji; Motoshima, Hiroyuki; Matsumura, Takeshi; Araki, Eiichi] Kumamoto Univ, Fac Life Sci, Dept Metab Med, Chuo Ward, Kumamoto, Japan.
   [Suico, Mary Ann; Kai, Hirofumi] Kumamoto Univ, Fac Life Sci, Dept Mol Med, Chuo Ward, Kumamoto, Japan.
C3 Kumamoto University; Kumamoto University; Kumamoto University
RP Kondo, T (corresponding author), Kumamoto Univ Hosp, Dept Diabet Metab & Endocrinol, Chuo Ward, Kumamoto, Japan.
EM t-kondo@gpo.kumamoto-u.ac.jp
RI Matsumura, Takeshi/B-3734-2011
OI Goto, Rieko/0000-0001-5370-4421
FU Japanese Government (MEdical Device InCubation (MEDIC) platform from the
   Ministry of Economy, Trade and Industry Japan) [24-065]; Grants-in-Aid
   for Scientific Research [21K08533, 20K07086] Funding Source: KAKEN
FX This study was supported by the Japanese Government (MEdical Device
   InCubation (MEDIC) platform from the Ministry of Economy, Trade and
   Industry Japan; Grant No. 24-065). The sponsor of this study had no role
   in the study design, data collection, data analysis, data
   interpretation, or writing of the report.
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NR 47
TC 4
Z9 4
U1 0
U2 0
PU BIOSCIENTIFICA LTD
PI BRISTOL
PA STARLING HOUSE, 1600 BRISTOL PARKWAY N, BRISTOL, ENGLAND
EI 2049-3614
J9 ENDOCR CONNECT
JI Endocr. Connect.
PD MAY
PY 2021
VL 10
IS 5
BP 521
EP 533
DI 10.1530/EC-21-0084
PG 13
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA SR5VW
UT WOS:000661111700008
PM 33883285
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Davis, CR
   Usher, N
   Dearing, E
   Barkai, AR
   Crowell-Doom, C
   Neupert, SD
   Mantzoros, CS
   Crowell, JA
AF Davis, Cynthia R.
   Usher, Nicole
   Dearing, Eric
   Barkai, Ayelet R.
   Crowell-Doom, Cynthia
   Neupert, Shevaun D.
   Mantzoros, Christos S.
   Crowell, Judith A.
TI Attachment and the Metabolic Syndrome in Midlife: The Role of
   Interview-Based Discourse Patterns
SO PSYCHOSOMATIC MEDICINE
LA English
DT Article
DE adult attachment; metabolic syndrome; adverse childhood experiences
ID ADVERSE CHILDHOOD EXPERIENCES; WORKING MODELS; SOCIAL RELATIONSHIPS;
   MEDICAL-TREATMENT; HEALTH BEHAVIOR; CHRONIC DISEASE; CENTRAL OBESITY;
   FOLLOW-UP; SELF-CARE; DEPRESSION
AB Objective Adult attachment discourse patterns and current family relationship quality were examined as correlates of health behaviors and number of metabolic syndrome (MetS) criteria met, and as mediators of the link between childhood adversity and these health outcomes.
   Methods A sample of 215 white/European American and black/African American adults aged 35 to 55 years were examined using a cross-sectional study design. Discourse was assessed with the Adult Attachment Interview, using coherence (a marker of attachment security), unresolved trauma/loss (a marker of disorganized cognitions related to trauma or loss), and idealization (minimizing stressful experiences and their impact) scores. Relationship quality, adverse childhood experiences, and current depressive symptoms were assessed, as were health behaviors of diet, exercise, and smoking. MetS includes obesity, elevated blood pressure, elevated fasting glucose, high triglycerides, and low high-density lipoprotein cholesterol.
   Results Using path analysis and including childhood adversity severity and depressive symptoms in the model, both Adult Attachment Interview coherence and unresolved trauma/loss were directly linked to the number of MetS criteria (r = 0.186 and r = 0.170, respectively). Idealization was indirectly linked to MetS through poor diet (r = 0.183). The final model explained 21% of the variance in scores for the number of MetS criteria met.
   Conclusions Insecure adult attachment is associated with increased risk of MetS.
C1 [Davis, Cynthia R.; Usher, Nicole; Crowell-Doom, Cynthia; Crowell, Judith A.] Judge Baker Childrens Ctr, Boston, MA USA.
   [Dearing, Eric] Boston Coll, Boston, MA USA.
   [Barkai, Ayelet R.] Cambridge Hlth Alliance, Dept Psychiat, Cambridge, MA USA.
   [Neupert, Shevaun D.] N Carolina State Univ, Dept Psychol, Raleigh, NC 27695 USA.
   [Mantzoros, Christos S.] Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Div Endocrinol, Boston, MA 02215 USA.
   [Mantzoros, Christos S.] Harvard Univ, Sch Med, Endocrinol Sect, Boston VA Healthcare Syst, Boston, MA USA.
   [Crowell, Judith A.] SUNY Stony Brook, Sch Med, Dept Psychiat, Stony Brook, NY 11794 USA.
C3 Harvard University; Harvard University Medical Affiliates; Judge Baker's
   Children's Center; Boston College; Harvard University; Harvard
   University Medical Affiliates; Cambridge Health Alliance; North Carolina
   State University; Harvard University; Harvard University Medical
   Affiliates; Beth Israel Deaconess Medical Center; Harvard Medical
   School; Harvard University; Harvard Medical School; Harvard University
   Medical Affiliates; US Department of Veterans Affairs; Veterans Health
   Administration (VHA); VA Boston Healthcare System; State University of
   New York (SUNY) System; Stony Brook University
RP Crowell, JA (corresponding author), SUNY Stony Brook, Div Child & Adolescent Psychiat, Putnam Hall South Campus, Stony Brook, NY 11794 USA.
EM judith.crowell@stonybrookmedicine.edu
RI Mantzoros, Christos/Y-2902-2019
OI Neupert, Shevaun/0000-0001-5994-3060
FU National Institute of Aging [R01 AG 032030]; National Institute of
   Diabetes and Digestive and Kidney Diseases [81913]; Harvard Clinical and
   Translational Science Center from National Center for Research Resources
   [UL1 RR025758]
FX This research was supported by the National Institute of Aging (Grant
   No. R01 AG 032030, to J.A. Crowell), National Institute of Diabetes and
   Digestive and Kidney Diseases (Grant No. 81913, to C. S. Mantzoros), and
   Harvard Clinical and Translational Science Center (Grant No. UL1
   RR025758, to C. S. Mantzoros) from the National Center for Research
   Resources. The authors have no conflicts of interest to disclose.
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NR 112
TC 18
Z9 21
U1 0
U2 25
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0033-3174
EI 1534-7796
J9 PSYCHOSOM MED
JI Psychosom. Med.
PD OCT
PY 2014
VL 76
IS 8
BP 611
EP 621
DI 10.1097/PSY.0000000000000107
PG 11
WC Psychiatry; Psychology; Psychology, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry; Psychology
GA AR9HK
UT WOS:000343883900005
PM 25264975
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Mykolayivna, NI
   Adebusoye, FT
   Awuah, WA
   Anatoliivna, SA
   Volodymyrivna, BT
   Fedorivna, HS
   Abdul-Rahman, T
AF Mykolayivna, Nikitina I.
   Adebusoye, Favor T.
   Awuah, Wireko A.
   Anatoliivna, Sinkina A.
   Volodymyrivna, Babar T.
   Fedorivna, Herasymenko S.
   Abdul-Rahman, Toufik
TI Stress-induced menstrual disorders in adolescents during the Ukrainian
   war: cross-sectional study
SO ANNALS OF MEDICINE AND SURGERY
LA English
DT Article
DE menstrual disorder; psychoemotional disorder; reproductive function;
   stress; war
ID METABOLIC SYNDROME; HEALTH
AB Objective:The objective was to investigate the peculiarities of menstrual cycle changes in teenagers exposed to a devastating war for an extended period. Methods:A cross-sectional study of 120 Ukrainian girls aged 9-18 asked to complete a survey about their menstrual cycle status 3-6 months after the war began. Other examination methods used included anthropometry, laboratory, and instrumental studies. Results:The frequency of menstrual cycle disorders in the study group was 65.8% (n=79). The following menstrual cycle disorders were most frequently reported; dysmenorrhea 45.6% (n=36), excessive menstruation during puberty 27.8% (n=22), and secondary amenorrhea 26.6% (n=21). The 52.5% (n=63) of those examined had pathological menarche. The 81.7% (n=63) of respondents reported a change in eating habits in the previous few months. The 61.9% (n=39) of these children had dyshormonal disorders or met the criteria for metabolic syndrome. Conclusion:Adolescent females under stress warrant a quick assessment of their psychoemotional and metabolic conditions. The protection from future menstruation and reproductive illnesses depends on this tactic. By diagnosing these conditions promptly and well-managed, adolescent females may maintain good physical and emotional health.
C1 [Mykolayivna, Nikitina I.; Adebusoye, Favor T.; Awuah, Wireko A.; Anatoliivna, Sinkina A.; Volodymyrivna, Babar T.; Fedorivna, Herasymenko S.; Abdul-Rahman, Toufik] Sumy State Univ, Sumy, Ukraine.
   [Adebusoye, Favor T.] Sumy State Univ, Fac Med, Sanatorna St 31, UA-40000 Sumy, Sumy Oblast, Ukraine.
C3 Ministry of Education & Science of Ukraine; Sumy State University;
   Ministry of Education & Science of Ukraine; Sumy State University
RP Adebusoye, FT (corresponding author), Sumy State Univ, Fac Med, Sanatorna St 31, UA-40000 Sumy, Sumy Oblast, Ukraine.
EM i.nikitina@med.sumdu.edu.ua; Favouradebusoye@gmail.com;
   andyvans36@yahoo.com; best.ane4ka.best@gmail.com;
   t.babar@med.sumdu.edu.ua; s.herasymenko@med.sumdu.edu.ua;
   Drakelin24@gmail.com
RI WIREKO, ANDREW AWUAH/ABD-3005-2021
OI ADEBUSOYE, FAVOUR TOPE/0000-0001-5362-3920
CR Abu Alwafa R, 2021, BMC WOMENS HEALTH, V21, DOI 10.1186/s12905-021-01374-6
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NR 23
TC 2
Z9 2
U1 2
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 2049-0801
J9 ANN MED SURG
JI Ann. Med. Surg.
PD JUL
PY 2023
VL 85
IS 7
BP 3428
EP 3433
DI 10.1097/MS9.0000000000000974
PG 6
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA L7KO7
UT WOS:001025013800028
PM 37427173
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Poojari, PG
   Khan, S
   Shenoy, S
   Shetty, S
   Bose, S
   Pai, KSV
   Acharya, LD
   Thunga, G
AF Poojari, Pooja Gopal
   Khan, Sohil
   Shenoy, Sonia
   Shetty, Sahana
   Bose, Swarnali
   Pai, Keshava
   Acharya, Leelavathi D.
   Thunga, Girish
TI A narrative review of metabolic monitoring of adult prescribed
   second-generation antipsychotics for severe mental illness
SO CLINICAL EPIDEMIOLOGY AND GLOBAL HEALTH
LA English
DT Review
DE Early interventions; Metabolic syndrome; Cardiovascular disease; Mental
   health; Second generation antipsychotics
ID PHYSICAL HEALTH; INTERVENTION; MANAGEMENT; IMPACT; TRIAL; CARE
AB Introduction: Patients with severe mental illness (SMI) have poor physical wellbeing, leading essentially shorter lives, compared with the general population. Routine metabolic monitoring is proposed as a strategy for recognizing risk factors for metabolic variations in this population. This narrative review aimed to identify interventions at enhancing uptake of metabolic monitoring parameters in adult prescribed second generation antipsychotics (SGAs) for patients with SMI.Method: A literature search was performed through SCOPUS, PubMed, and CINAHL databases using a combination of keywords. We included primary studies published in the English language until December 2021 that provided evidence on interventions to increase the rate of SGAs related metabolic monitoring in patients with SMI. Results: A total of 21 studies were identified among which in 13 studies frequency of metabolic monitoring ranged between 40% and 80% after implementation of various strategies. These include multi-layer intervention model such as: (A) Reminders (e.g., paper-based prompts, invitation letter); (B) Electronic system of documentation (computer-based intervention, electronic medical records); (C) Healthcare practitioner specific role (Nurse-led intervention, pharmacist-led intervention, barrier focused strategies) and (D) Physical-mental health awareness (Education, quality improvement programme).Conclusion: This review provides evidence that studies involving the reminders such as paper based prompts and education to the patients as well as healthcare professionals could help in enhancing the rate of metabolic monitoring in patients prescribed SGAs.
C1 [Poojari, Pooja Gopal; Khan, Sohil; Acharya, Leelavathi D.; Thunga, Girish] Manipal Acad Higher Educ, Manipal Coll Pharmaceut Sci, Dept Pharm Practice, Manipal 576104, Karnataka, India.
   [Khan, Sohil] Griffith Univ, Menzies Hlth Inst, Sch Pharm & Med Sci, Gold Coast, Australia.
   [Shenoy, Sonia] Manipal Acad Higher Educ, Kasturba Med Coll, Dept Psychiat, Manipal 576104, Karnataka, India.
   [Shetty, Sahana] Manipal Acad Higher Educ, Kasturba Med Coll, Dept Endocrinol, Manipal 576104, Karnataka, India.
   [Bose, Swarnali] Cent Inst Psychiat, Dept Clin Psychol, Ranchi 834006, Jharkhand, India.
   [Pai, Keshava] Kasturba Med Coll & Hosp, Dept Psychiat, Mangalore 575002, Karnataka, India.
C3 Manipal Academy of Higher Education (MAHE); Menzies Health Institute
   Queensland; Griffith University; Griffith University - Gold Coast
   Campus; Manipal Academy of Higher Education (MAHE); Kasturba Medical
   College, Manipal; Manipal Academy of Higher Education (MAHE); Kasturba
   Medical College, Manipal; Central Institute of Psychiatry; Manipal
   Academy of Higher Education (MAHE); Kasturba Medical College, Mangalore
RP Thunga, G (corresponding author), Manipal Acad Higher Educ, Manipal Coll Pharmaceut Sci, Dept Pharm Practice, Manipal 576104, Karnataka, India.
EM pooja.poojari@learner.manipal.edu; s.khan@griffith.edu.au;
   sonia.shenoy@manipal.edu; sahana.shetty@manipal.edu;
   swarnali.bose@rediffmail.com; pai.keshava@manipal.edu;
   leela.da@manipal.edu
RI Shenoy, Sonia/AAU-6047-2020; Shetty, Sahana/AAA-6271-2022; Pai,
   Keshava/LTE-0063-2024
OI Shetty, Sahana/0000-0003-0851-0411
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NR 30
TC 5
Z9 6
U1 0
U2 1
PU ELSEVIER - DIVISION REED ELSEVIER INDIA PVT LTD
PI NEW DELHI
PA 17-A/1 MAIN RING ROAD, LAJPAT NAGAR IV, NEW DELHI, 110024, INDIA
SN 2452-0918
EI 2213-3984
J9 CLIN EPIDEMIOL GLOB
JI Clin. Epidemiol. Glob. Health
PD MAY-JUN
PY 2022
VL 15
AR 101035
DI 10.1016/j.cegh.2022.101035
EA MAR 2022
PG 8
WC Public, Environmental & Occupational Health
WE Emerging Sources Citation Index (ESCI)
SC Public, Environmental & Occupational Health
GA 0Z7YD
UT WOS:000791288200024
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Dominiczak, MH
AF Dominiczak, MH
TI Obesity, glucose intolerance and diabetes and their links to
   cardiovascular disease. Implications for laboratory medicine
SO CLINICAL CHEMISTRY AND LABORATORY MEDICINE
LA English
DT Review
DE type 2 diabetes mellitus; obesity; cardiovascular disease; metabolic
   syndrome
ID C-REACTIVE PROTEIN; CORONARY-HEART-DISEASE; FACTOR-KAPPA-B;
   INSULIN-RESISTANCE; RISK-FACTORS; OXIDATIVE STRESS; ENDOTHELIAL
   DYSFUNCTION; TRANSCRIPTION FACTOR; SIGNALING PATHWAYS; METABOLIC
   SYNDROME
AB This article provides an overview of the role of metabolite toxicity, lowgrade inflammation and disturbed cellular signaling in obesity, glucose intolerance and diabetes. It also highlights links between this continuum of deteriorating glucose tolerance and atherosclerosis.
   Obesity, diabetes mellitus, and cardiovascular disease are all related to diet and to the level of physical activity. They have reached epidemic proportions worldwide. Glucose intolerance and diabetes increase the risk of atherosclerotic events. Moreover, obesity, and glucose intolerance or diabetes, are components of the metabolic syndrome, which also imparts an increased cardiovascular risk. There is increasing recognition that common mechanisms contribute to diabetes and cardiovascular disease. Following increased calorie intake and/or decreased physical activity, fuel metabolism generates excess of toxic metabolites, particularly glucose and fatty acids. Homeostasis is affected by the endocrine output from the adipose tissue. Reactive oxygen species are generated, creating oxidative stress, which exerts major effects on signaling pathways, further affecting cellular metabolism and triggering lowgrade inflammatory reaction.
   This perspective on the diabetic syndrome has been reflected in the approach to its treatment, which integrates maintenance of glycemic control with primary and secondary cardiovascular prevention. Laboratory medicine should support diabetes care with an integrated package of tests which, in addition to glycemic control, enable assessment and monitoring of the risk of microvascular complications as well as cardiovascular disease.
C1 Gartnavel Royal Hosp, Dept Biochem, Glasgow G12 0YN, Lanark, Scotland.
   N Glasgow Univ Hosp NHS Trust, Med Humanities Unit, Glasgow, Lanark, Scotland.
C3 Gartnavel Royal Hospital; University of Glasgow
RP Gartnavel Royal Hosp, Dept Biochem, 1053 Great Western Rd, Glasgow G12 0YN, Lanark, Scotland.
EM m.h.dominiczak@clinmed.gla.ac.uk
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NR 133
TC 31
Z9 38
U1 0
U2 6
PU WALTER DE GRUYTER GMBH
PI BERLIN
PA GENTHINER STRASSE 13, D-10785 BERLIN, GERMANY
SN 1434-6621
EI 1437-4331
J9 CLIN CHEM LAB MED
JI Clin. Chem. Lab. Med.
PY 2003
VL 41
IS 9
BP 1266
EP 1278
DI 10.1515/CCLM.2003.194
PG 13
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA 722TD
UT WOS:000185392000024
PM 14598880
DA 2025-06-11
ER

PT J
AU Barton, BB
   Segger, F
   Fischer, K
   Obermeier, M
   Musil, R
AF Barton, Barbara B.
   Segger, Felix
   Fischer, Kai
   Obermeier, Michael
   Musil, Richard
TI Update on weight-gain caused by antipsychotics: a systematic review and
   meta-analysis
SO EXPERT OPINION ON DRUG SAFETY
LA English
DT Review
DE Aripiprazole; asenapine; brexpiprazole; cariprazine; lurasidone; number
   needed to harm; olanzapine; quetiapine extended release; risperidone;
   transdiagnostically
ID PLACEBO-CONTROLLED TRIAL; EXTENDED-RELEASE QUETIAPINE; BIPOLAR I
   DEPRESSION; DOUBLE-BLIND; ACUTE EXACERBATION; 2ND-GENERATION
   ANTIPSYCHOTICS; ATYPICAL ANTIPSYCHOTICS; ASIAN PATIENTS; RISK-FACTORS;
   ACUTE MANIA
AB Introduction: Antipsychotic-induced weight-gain (AIWG) is a very important, yet often neglected side-effect in the treatment with first and second generation antipsychotics. AIWG can increase the risk of developing metabolic syndrome, diabetes and cardiovascular disease. Meta-analyzes mostly concentrate on AIWG in schizophrenic and bipolar patients, even though antipsychotics are prescribed off-label across many other diagnostic groups (e.g. anxiety disorders, depression, autistic disorder). Areas covered: Pub Med and Web of Science were systematically searched for RCTs reporting on AIWG with a sample size of >= 100 published between 2014 and 2019. All diagnoses and ages were included. Expert opinion: Inclusion criteria were fulfilled by 27 RCTs. All antipsychotics led to significantly more weight-gain (p < .001) and most antipsychotics led to a significantly higher risk for a clinically relevant weight-gain of >= 7% compared to placebo (RR = 2.04). The results support previous findings that weight-gain occurs quickly. To efficaciously and efficiently tackle the problem of AIWG in clinical practice and trials, people at high risk need to be identified by predictive tools enabling the clinician to offer tailored adjunctive therapies (medication and/or lifestyle interventions). Most importantly, weight and metabolic monitoring ought to be consequently implemented in clinical routine in the treatment of any patient with any diagnosis when antipsychotics are prescribed.
C1 [Barton, Barbara B.; Segger, Felix; Fischer, Kai; Musil, Richard] Ludwig Maximilians Univ Munchen, Univ Hosp, Dept Psychiat & Psychotherapy, Nussbaumstr 7, D-80336 Munich, Germany.
   [Obermeier, Michael] Gesell Therapieforsch MbH, GKM, Munich, Germany.
C3 University of Munich
RP Barton, BB (corresponding author), Ludwig Maximilians Univ Munchen, Univ Hosp, Dept Psychiat & Psychotherapy, Nussbaumstr 7, D-80336 Munich, Germany.
EM barbara.barton@med.uni-muenchen.de
RI Musil, Richard/AAF-4331-2020
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NR 80
TC 148
Z9 154
U1 0
U2 39
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1474-0338
EI 1744-764X
J9 EXPERT OPIN DRUG SAF
JI Expert Opin. Drug Saf.
PD MAR 3
PY 2020
VL 19
IS 3
BP 295
EP 314
DI 10.1080/14740338.2020.1713091
EA MAR 2020
PG 20
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Pharmacology & Pharmacy
GA MB1QS
UT WOS:000519515000001
PM 31952459
DA 2025-06-11
ER

PT J
AU Zhou, Q
   Zhou, LJ
   Chen, X
   Chen, QY
   Hao, L
AF Zhou, Qing
   Zhou, Lijun
   Chen, Xi
   Chen, Qiuyan
   Hao, Lu
TI Composite dietary antioxidant index is associated with reduced
   prevalence of metabolic syndrome but not mortality in metabolic
   syndrome: Results from NHANES 2001-2018
SO PREVENTIVE MEDICINE REPORTS
LA English
DT Article
DE Metabolic syndrome; NHANES; Diet; Antioxidants; Mortality
ID MODERATE ALCOHOL-CONSUMPTION; OXIDATIVE STRESS; RISK
AB The relationship between the composite dietary antioxidant index (CDAI), a comprehensive measure of individual dietary antioxidants, and the prevalence and mortality of metabolic syndrome (MetS) remains unknown. We aimed to explore these relationships in the National Health and Nutrition Examination Survey (NHANES). We explored these relationships using two independent cohorts. First, we addressed CDAI and the prevalence of MetS in the general population; second, we explored the association between CDAI and mortality in patients with MetS by following NHANES 2001-2018 participants through December 31, 2019. In addition, restricted cubic spline (RCS), stratified analysis, and sensitivity analysis were used for further interpretation. We included 24,514 participants aged 20-85 years, in which the prevalence of MetS was 27.61 %. CDAI was negatively and doseresponsively associated with the prevalence of MetS, however it was not associated with mortality in patients with MetS. In addition, CDAI was associated with a reduced prevalence of certain components of MetS, including dyslipidemia and central obesity. RCS showed a linear correlation between CDAI and MetS and the above components. Stratified analyses indicated that alcohol consumption was a significant influence of CDAI-MetS and that socioeconomic status and lifestyle specificity existed. Sensitivity analysis confirmed the stability of the results. CDAI was protective against the development of MetS in the general population, but not against mortality in patients with MetS. Clinicians need to develop individualized prevention strategies to reduce the development of MetS by modifying CDAI.
C1 [Zhou, Qing; Chen, Xi] Peoples Hosp Baoan Shenzhen, Cent Lab, Shenzhen, Peoples R China.
   [Zhou, Lijun] Peoples Hosp Baoan Shenzhen, Dept Urol, Shenzhen, Peoples R China.
   [Chen, Qiuyan; Hao, Lu] Shenzhen Baoan Shiyan Peoples Hosp, Sci & Educ Dept, Shenzhen, Peoples R China.
RP Hao, L (corresponding author), Shenzhen Baoan Shiyan Peoples Hosp, Sci & Educ Dept, Shenzhen, Peoples R China.
EM haolu8686@sina.com
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NR 43
TC 9
Z9 9
U1 4
U2 21
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
EI 2211-3355
J9 PREV MED REP
JI Prev. Med. Rep.
PD MAY
PY 2024
VL 41
AR 102704
DI 10.1016/j.pmedr.2024.102704
PG 7
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA QL2L8
UT WOS:001220963000001
PM 38576515
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Merabet, N
   Fang, YH
   Nicol, L
   Monteil, C
   Rémy-Jouet, I
   Henry, JP
   Wecker, D
   Le Bouter-Banon, S
   Roussel, J
   Richard, V
   Thuillez, C
   Mulder, P
AF Merabet, Nassiba
   Fang, Yuehua
   Nicol, Lionel
   Monteil, Christelle
   Remy-Jouet, Isabelle
   Henry, Jean-Paul
   Wecker, Didier
   Le Bouter-Banon, Sabrina
   Roussel, Jerome
   Richard, Vincent
   Thuillez, Christian
   Mulder, Paul
TI Selective Heart Rate Reduction Improves Metabolic Syndrome-related Left
   Ventricular Diastolic Dysfunction
SO JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
LA English
DT Article
DE diastolic function; metabolic syndrome; heart rate reduction
ID CORONARY-ARTERY-DISEASE; FAILING DIABETIC HEART; OXIDATIVE STRESS;
   ENDOTHELIAL DYSFUNCTION; NITRIC-OXIDE; CONTRACTILE DYSFUNCTION;
   BRADYCARDIAC AGENT; BLOOD-FLOW; IVABRADINE; FAILURE
AB Background: Enhanced heart rate observed in metabolic syndrome ( MS) contributes to the deterioration of left ventricular ( LV) function via impaired LV filling and relaxation, increased myocardial O-2 consumption, and reduced coronary perfusion. However, whether heart rate reduction (HRR) opposes LV dysfunction observed in MS is unknown. Methods: We assessed in Zucker fa/fa rats, a rat model of MS, the cardiovascular effects of HRR induced by the If current inhibitor S38844 ( 3 mg center dot kg21 center dot d(-1)). Results: Delayed short-term ( 4 days) and long-term ( 90 days) HRR induced by S38844 reduced LV end-diastolic pressure and LV enddiastolic pressure-volume relation, increased myocardial tissue perfusion, decreased myocardial oxidized glutathione levels, and preserved cardiac output, without modifying LV end-systolic pressure and LV end-systolic pressure-volume relation, although only long-term S38844 opposed LV collagen accumulation. Long-term S38844 improved flow-induced endothelium-dependent dilatation of mesenteric arteries, while metabolic parameters, such as plasma glucose levels, and Hb1c, were never modified. Conclusions: In rats with MS, HRR induced by the If inhibitor S38844 improved LV diastolic function and endothelium- dependent vascular dilatation, independent from modifications in metabolic status. Moreover, this improvement in cardiac function involves not only immediate effects such as improved myocardial perfusion and reduced oxidative stress but also long- term effects such as modifications in the myocardial structure.
C1 [Merabet, Nassiba; Fang, Yuehua; Nicol, Lionel; Monteil, Christelle; Remy-Jouet, Isabelle; Henry, Jean-Paul; Richard, Vincent; Thuillez, Christian; Mulder, Paul] INSERM, U1096, Rouen, France.
   [Merabet, Nassiba; Fang, Yuehua; Nicol, Lionel; Remy-Jouet, Isabelle; Henry, Jean-Paul; Richard, Vincent; Thuillez, Christian; Mulder, Paul] Inst Res & Innovat Biomed, Rouen, France.
   [Merabet, Nassiba; Fang, Yuehua; Nicol, Lionel; Monteil, Christelle; Remy-Jouet, Isabelle; Henry, Jean-Paul; Richard, Vincent; Thuillez, Christian; Mulder, Paul] Univ Rouen, UFR Med & Pharm, Rouen, France.
   [Nicol, Lionel; Thuillez, Christian; Mulder, Paul] Univ Rouen, Plateau Imagerie CardioThorac, Rouen, France.
   [Monteil, Christelle] Equipe Acceuil 4651, Aliment Bioproc Toxicol Environm, Rouen, France.
   [Wecker, Didier] Bruker Biospin MRI GMBH, Ettlingen, Germany.
   [Le Bouter-Banon, Sabrina; Roussel, Jerome] Servier, Suresnes, France.
C3 Institut National de la Sante et de la Recherche Medicale (Inserm);
   Universite de Rouen Normandie; Universite de Rouen Normandie; Universite
   de Rouen Normandie; Bruker Corporation; Bruker BioSpin GmbH
RP Mulder, P (corresponding author), UFR Med & Pharm, INSERM U1096, 22 Blvd Gambetta, F-76183 Rouen, France.
EM paul.mulder@univ-rouen.fr
RI Monteil, Christelle/ABF-3312-2022; Richard, Vincent/B-1059-2014
OI Mulder, Paul/0000-0002-5936-5704; Richard, Vincent/0000-0003-0590-0158;
   Monteil, Christelle/0000-0002-4981-0800
FU SERVIER; FEDER
FX Supported by a research grant of SERVIER and FEDER. Moreover, assistance
   of Elodie Gomez and Ji Gao and Julie Favre was gratefully acknowledged.
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NR 61
TC 10
Z9 10
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0160-2446
EI 1533-4023
J9 J CARDIOVASC PHARM
JI J. Cardiovasc. Pharmacol.
PD OCT
PY 2015
VL 66
IS 4
BP 399
EP 408
DI 10.1097/FJC.0000000000000294
PG 10
WC Cardiac & Cardiovascular Systems; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Pharmacology & Pharmacy
GA CT5JL
UT WOS:000362845100011
PM 26222991
DA 2025-06-11
ER

PT J
AU El Hafidi, M
   Pérez, I
   Baños, G
AF El Hafidi, M
   Pérez, I
   Baños, G
TI Is glycine effective against elevated blood pressure?
SO CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE
LA English
DT Article
DE glycine; hypertension; metabolic syndrome; oxidative stress
ID LOW-PROTEIN-DIET; NITRIC-OXIDE; IN-VIVO; METABOLIC RESPONSE;
   ENDOTHELIAL-CELLS; LIVER-INJURY; AMINO-ACIDS; HYPERTENSION; RAT;
   GLUTATHIONE
AB Purpose of review
   Glycine, a non-essential amino acid, has been found to protect against oxidative stress in several pathological situations, and it is required for the biosynthesis of structural proteins such as elastin. As hypertension is a disease in which free radicals and large vessel elasticity are involved, this article will examine the possible mechanisms by which glycine may protect against high blood pressure.
   Recent findings
   The addition of glycine to the diet reduces high blood pressure in a rat model of the metabolic syndrome. Also, glycine supplemented to the low protein diet of rat dams during pregnancy has a beneficial effect on blood pressure in their offspring. The mechanism by which glycine decreases high blood pressure can be attributed to its participation in the reduction of the generation of free radicals, increasing the availability of nitric oxide. In addition, as glycine is required for a number of critical metabolic pathways, such as the synthesis of the structural proteins collagen and elastin, the perturbation of these leads to impaired elastin formation in the aorta. This involves changes in the aorta's elastic properties, which would contribute to the development of hypertension.
   Summary
   The use of glycine to lower high blood pressure could have a significant clinical impact in patients with the metabolic syndrome and with limited resources, On the other hand, more studies are needed to explore the beneficial effect of glycine in other models of hypertension and to investigate possible side-effects of treatment with glycine.
C1 Inst Nacl Cardiol Ignacio Chavez, Dept Biochem, Mexico City 14080, DF, Mexico.
   Inst Nacl Cardiol Ignacio Chavez, Dept Pathol, Mexico City 14080, DF, Mexico.
C3 National Institute of Cardiology - Mexico; National Institute of
   Cardiology - Mexico
RP Inst Nacl Cardiol Ignacio Chavez, Dept Biochem, Juan Badiano 1, Mexico City 14080, DF, Mexico.
EM elhafidi@mail.ssa.gov.mx
RI El-Hafidi, Mohammed/AAN-4083-2021
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NR 47
TC 55
Z9 62
U1 1
U2 11
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1363-1950
EI 1473-6519
J9 CURR OPIN CLIN NUTR
JI Curr. Opin. Clin. Nutr. Metab. Care
PD JAN
PY 2006
VL 9
IS 1
BP 26
EP 31
PG 6
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 015KT
UT WOS:000235551000007
PM 16444815
DA 2025-06-11
ER

PT J
AU Diaz, A
   Muñoz-Arenas, G
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   Treviño, S
AF Diaz, Alfonso
   Munoz-Arenas, Guadalupe
   Venegas, Berenice
   Vazquez-Roque, Ruben
   Flores, Gonzalo
   Guevara, Jorge
   Gonzalez-Vergara, Enrique
   Trevino, Samuel
TI Metforminium Decavanadate (MetfDeca) Treatment Ameliorates Hippocampal
   Neurodegeneration and Recognition Memory in a Metabolic Syndrome Model
SO NEUROCHEMICAL RESEARCH
LA English
DT Article
DE Vanadium; Spines dendritic; Golgi-Cox; Interleukins; Reactive oxygen
   species; Inflammation
ID INSULIN-RESISTANCE; OXIDATIVE STRESS; BISPEROXOVANDIUM
   PYRIDIN-2-SQUARAMIDE; ALZHEIMERS-DISEASE; VANADIUM COMPOUNDS;
   DIABETES-MELLITUS; TEMPORAL CORTEX; BRAIN; INFLAMMATION; MECHANISMS
AB The consumption of foods rich in carbohydrates, saturated fat, and sodium, accompanied by a sedentary routine, are factors that contribute to the progress of metabolic syndrome (MS). In this way, they cause the accumulation of body fat, hypertension, dyslipidemia, and hyperglycemia. Additionally, MS has been shown to cause oxidative stress, inflammation, and death of neurons in the hippocampus. Consequently, spatial and recognition memory is affected. It has recently been proposed that metformin decavanadate (MetfDeca) exerts insulin mimetic effects that enhance metabolism in MS animals; however, what effects it can cause on the hippocampal neurons of rats with MS are unknown. The objective of the work was to evaluate the effect of MetfDeca on hippocampal neurodegeneration and recognition memory in rats with MS. Administration of MetfDeca for 60 days in MS rats improved object recognition memory (NORt). In addition, MetfDeca reduced markers of oxidative stress and hippocampal neuroinflammation. Accompanied by an increase in the density and length of the dendritic spines of the hippocampus of rats with MS. We conclude that MetfDeca represents an important therapeutic agent to treat MS and induce neuronal and cognitive restoration mechanisms.
C1 [Diaz, Alfonso; Munoz-Arenas, Guadalupe; Trevino, Samuel] Benemerita Autonomous Univ Puebla, Fac Chem Sci, Puebla, Pue, Mexico.
   [Venegas, Berenice] Benemerita Autonomous Univ Puebla, Fac Biol Sci, Puebla, Pue, Mexico.
   [Vazquez-Roque, Ruben; Flores, Gonzalo] Benemerita Autonomous Univ Puebla, Inst Physiol, Lab Neuropsychiat, Puebla, Pue, Mexico.
   [Guevara, Jorge] Univ Nacl Autonoma Mexico, Fac Med, Dept Biochem, Mexico City, DF, Mexico.
   [Gonzalez-Vergara, Enrique] Benemerita Autonomous Univ Puebla, ICUAP, Chem Ctr, Puebla, Pue, Mexico.
C3 Benemerita Universidad Autonoma de Puebla; Benemerita Universidad
   Autonoma de Puebla; Benemerita Universidad Autonoma de Puebla;
   Universidad Nacional Autonoma de Mexico; Benemerita Universidad Autonoma
   de Puebla
RP Treviño, S (corresponding author), Benemerita Autonomous Univ Puebla, Fac Chem Sci, Puebla, Pue, Mexico.
EM samuel_trevino@hotmail.com
RI Vergara, Enrique/M-7641-2017; Vazquez Roque, Ruben/L-5757-2013; Flores,
   Gonzalo/B-1807-2014; Venegas, Berenice/AAG-4048-2021
OI Vazquez Roque, Ruben/0000-0002-2712-5714; VENEGAS MENESES,
   BERENICE/0000-0001-9009-655X; Flores, Gonzalo/0000-0002-4100-2104; Diaz,
   Alfonso/0000-0003-4092-6636
FU VIEPBUAP Grant [DIFA-NAT19-G, TEMS-NAT19-I]; PAPIIT-UNAM [IN214117]
FX Funding for this study was provided by grants from VIEPBUAP Grant (No.
   DIFA-NAT19-G) to DA and ST, (No. TEMS-NAT19-I) to TS and PAPIIT-UNAM
   (IN214117) to JG. None of the funding institutions had any further role
   in the study design, the collection of data, analyses, and
   interpretation of data, writing of the report or in the decision to
   submit the paper for publication and interpretation of data, writing of
   the report or the decision to submit the paper for publication.
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NR 81
TC 12
Z9 12
U1 0
U2 9
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0364-3190
EI 1573-6903
J9 NEUROCHEM RES
JI Neurochem. Res.
PD MAY
PY 2021
VL 46
IS 5
BP 1151
EP 1165
DI 10.1007/s11064-021-03250-z
EA FEB 2021
PG 15
WC Biochemistry & Molecular Biology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Neurosciences & Neurology
GA RO2IP
UT WOS:000616443800001
PM 33559829
DA 2025-06-11
ER

PT J
AU Lin, HY
   Lu, JH
   Lin, RJ
   Chueh, KS
   Juan, TJ
   Mao, JW
   Lee, YC
   Chuang, SM
   Shen, MC
   Sun, TW
   Juan, YS
AF Lin, Hung-Yu
   Lu, Jian-He
   Lin, Rong-Jyh
   Chueh, Kuang-Shun
   Juan, Tai-Jui
   Mao, Jing-Wen
   Lee, Yi-Chen
   Chuang, Shu-Mien
   Shen, Mei-Chen
   Sun, Ting-Wei
   Juan, Yung-Shun
TI Effects of Nitric Oxide on Bladder Detrusor Overactivity through the
   NRF2 and HIF-1α Pathways: A Rat Model Induced by Metabolic Syndrome and
   Ovarian Hormone Deficiency
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE nitric oxide; metabolic syndrome; ovarian hormone deficiency; overactive
   bladder; high-fat high-sugar diet
ID URINARY-TRACT SYMPTOMS; GREEN TEA CATECHINS; C-REACTIVE PROTEIN;
   L-ARGININE; OXIDATIVE STRESS; ISCHEMIA-REPERFUSION; SYNTHASE INHIBITION;
   INSULIN-RESISTANCE; L-NAME; RECEPTOR
AB Metabolic syndrome (MetS) includes cardiovascular risk factors like obesity, dyslipidemia, hypertension, and glucose intolerance, which increase the risk of overactive bladder (OAB), characterized by urgency, frequency, urge incontinence, and nocturia. Both MetS and ovarian hormone deficiency (OHD) are linked to bladder overactivity. Nitric oxide (NO) is known to reduce inflammation and promote healing but its effect on bladder overactivity in MetS and OHD is unclear. This study aimed to investigate NO's impact on detrusor muscle hyperactivity in rats with MetS and OHD. Female Sprague-Dawley rats were divided into seven groups based on diet and treatments involving L-arginine (NO precursor) and L-NAME (NOS inhibitor). After 12 months on a high-fat, high-sugar diet with or without OVX, a cystometrogram and tracing analysis of voiding behavior were used to identify the symptoms of detrusor hyperactivity. The MetS with or without OHD group had a worse bladder contractile response while L-arginine ameliorated bladder contractile function. In summary, MetS with or without OHD decreased NO production, reduced angiogenesis, and enhanced oxidative stress to cause bladder overactivity, mediated through the NF-kB signaling pathway, whereas L-arginine ameliorated the symptoms of detrusor overactivity and lessened oxidative damage via the NRF2/HIF-1 alpha signaling pathway in MetS with or without OHD-induced OAB.
C1 [Lin, Hung-Yu] I Shou Univ, Sch Med, Kaohsiung 84001, Taiwan.
   [Lin, Hung-Yu] I Shou Univ, E Da Canc Hosp, Dept Surg, Div Urol, Kaohsiung 840301, Taiwan.
   [Lin, Hung-Yu] I Shou Univ, E Da Hosp, Dept Obstet & Gynecol, Kaohsiung 82445, Taiwan.
   [Lu, Jian-He] Natl Pingtung Univ Sci & Technol, Gen Res Serv Ctr, Pingtung Cty 912301, Taiwan.
   [Lin, Rong-Jyh] Kaohsiung Med Univ, Coll Med, Sch Med, Dept Parasitol, Kaohsiung 807378, Taiwan.
   [Chueh, Kuang-Shun; Juan, Yung-Shun] Kaohsiung Med Univ, Grad Inst Clin Med, Coll Med, Kaohsiung 807378, Taiwan.
   [Chueh, Kuang-Shun] Kaohsiung Municipal Tatung Hosp, Dept Urol, Kaohsiung 80661, Taiwan.
   [Chueh, Kuang-Shun; Mao, Jing-Wen; Chuang, Shu-Mien; Shen, Mei-Chen; Sun, Ting-Wei; Juan, Yung-Shun] Kaohsiung Med Univ Hosp, Dept Urol, Kaohsiung 80756, Taiwan.
   [Juan, Tai-Jui] Kaohsiung Armed Forces Gen Hosp, Kaohsiung 802301, Taiwan.
   [Juan, Tai-Jui] Kaohsiung Vet Gen Hosp, Dept Surg, Div Neurosurg, Kaohsiung 813414, Taiwan.
   [Lee, Yi-Chen] Kaohsiung Med Univ, Coll Med, Sch Med, Dept Anat, Kaohsiung 807378, Taiwan.
   [Chuang, Shu-Mien; Shen, Mei-Chen; Sun, Ting-Wei; Juan, Yung-Shun] Kaohsiung Med Univ, Coll Med, Dept Urol, Kaohsiung 807378, Taiwan.
C3 I Shou University; E-Da Hospital; I Shou University; I Shou University;
   E-Da Hospital; National Pingtung University Science & Technology;
   Kaohsiung Medical University; Kaohsiung Medical University; Kaohsiung
   Medical University; Kaohsiung Municipal Ta-Tung Hospital; Kaohsiung
   Medical University; Kaohsiung Medical University Hospital; Kaohsiung
   Veterans General Hospital; Kaohsiung Medical University; Kaohsiung
   Medical University
RP Juan, YS (corresponding author), Kaohsiung Med Univ, Grad Inst Clin Med, Coll Med, Kaohsiung 807378, Taiwan.; Juan, YS (corresponding author), Kaohsiung Med Univ Hosp, Dept Urol, Kaohsiung 80756, Taiwan.; Juan, YS (corresponding author), Kaohsiung Med Univ, Coll Med, Dept Urol, Kaohsiung 807378, Taiwan.
EM ed100464@edah.org.tw; toddherpuma@mail.npust.edu.tw; rjlin@kmu.edu.tw;
   spacejason69@yahoo.com.tw; erryjuan@gmail.com; blast2337@gmail.com;
   yichen83@kmu.edu.tw; u9181002@gmail.com; bear5824@gmail.com;
   ting.wei0220@gmail.com; 840066@kmu.edu.tw
RI Lin, Rong-Jyh/D-5036-2009; 闕, 光瞬/KQU-3018-2024
FU Ministry of Science and Technology; NSTC [113-2221-E-020-007, MOST
   111-2221-E-020-004]; Department of Medical Research, Kaohsiung Medical
   University Hospital [KMUH-110-0M55, KMUH-111-1R53, KMUH-112-2R58,
   KMTTH-110-030, KMTTH-111-R010];  [NSTC112-2314-B-037-118]; 
   [MOST111-2314-B-037-066];  [MOST111-2314-B-037-072]
FX This research is supported by the grants from the Ministry of Science
   and Technology NSTC112-2314-B-037-118 (Yung-Shun Juan),
   MOST111-2314-B-037-066 (Yung-Shun Juan), MOST111-2314-B-037-072
   (Kuang-Shun Chueh), NSTC 113-2221-E-020-007 (Jian-He Lu), MOST
   111-2221-E-020-004 (Jian-He Lu), and in part by the Department of
   Medical Research, Kaohsiung Medical University Hospital (KMUH-110-0M55;
   KMUH-111-1R53; KMUH-112-2R58 (Yung-Shun Juan) and KMTTH-110-030;
   KMTTH-111-R010 (Kuang-Shun Chueh)).
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NR 84
TC 2
Z9 2
U1 0
U2 0
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD OCT
PY 2024
VL 25
IS 20
AR 11103
DI 10.3390/ijms252011103
PG 33
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA K1C6F
UT WOS:001341335300001
PM 39456884
OA gold
DA 2025-06-11
ER

PT J
AU Demirtas, CY
   Bircan, FS
   Pasaoglu, OT
   Turkozkan, N
AF Demirtas, Yilmaz C.
   Bircan, F. S.
   Pasaoglu, O. T.
   Turkozkan, N.
TI The effects of resveratrol on hepatic oxidative stress in metabolic
   syndrome model induced by high fructose diet
SO BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY
LA English
DT Article
DE resveratrol; metabolic syndrome; fructose; oxidative stress; liver
ID CARDIOVASCULAR-DISEASES; POTENTIAL ROLE; POLYPHENOLS; LIVER; EXPRESSION;
   OXIDANT; OBESITY; KIDNEY; RATS
AB BACKGROUND: The purpose of this study was to evaluate probable protective effects of resveratrol treatment on hepatic oxidative events in a rat model of metabolic syndrome (MetS).
   METHODS: Thirty-two male adult rats were randomly divided into 4 groups: control, fructose, resveratrol, and fructose plus resveratrol. To induce MetS, fructose solution (20 % in drinking water) was used. Resveratrol (10 mg/kg/day) was given by oral gavage. All treatments were given for 8 weeks. Serum lipid profile, glucose and insulin levels, liver total oxidant status (TOS) levels and paraoxonase (PON), glutathione peroxidase (GPx), superoxide dismutase (SOD) and catalase (CAT) activities were analyzed.
   RESULTS: Fructose-fed rats displayed statistically significant increases in TOS levels, and decreases in PON activity compared to the control group. Resveratrol treatment moderately prevented the decrease in liver PON activity caused by fructose. On the other hand, resveratrol, alone or in combination with fructose, did not change the TOS levels when compared to the fructose group. The SOD and CAT activities in all groups did not change.
   CONCLUSION: In this experimental design, high-fructose consumption led to elevated TOS levels and low PON activities. The resveratrol therapy shown beneficial effects on PON activity. However, it was found to behave like a prooxidant when administered together with fructose and alone in some parameters. Our results can inspire the development of new clinical therapy in patients with MetS (Tab. 2, Ref. 34).
C1 [Demirtas, Yilmaz C.; Bircan, F. S.; Pasaoglu, O. T.; Turkozkan, N.] Gazi Univ, Dept Biochem, Fac Med, Ankara, Turkey.
   [Bircan, F. S.] Gazi Univ, Dept Biol, Fac Sci, TR-06500 Ankara, Turkey.
   [Pasaoglu, O. T.] Gazi Univ, Fac Hlth Sci, Ankara, Turkey.
C3 Gazi University; Gazi University; Gazi University
RP Bircan, FS (corresponding author), Gazi Univ, Dept Biol, Fac Sci, TR-06500 Ankara, Turkey.
EM fsbircan@yahoo.com
RI Yılmaz, Canan/AAT-7788-2020; Pasaoglu, Ozge/AAZ-5223-2020
OI Bircan, Filiz Sezen/0000-0002-1007-2484; YILMAZ,
   CANAN/0000-0002-6799-6522
FU Gazi University, Department of Scientific Research Projects Unit
   [01/2010-17]
FX This study was supported by Gazi University, Department of Scientific
   Research Projects Unit (Project Number: 01/2010-17).
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NR 34
TC 20
Z9 22
U1 1
U2 8
PU AEPRESS SRO
PI BRATISLAVA
PA BAJZOVA 7, BRATISLAVA, 821 08, SLOVAKIA
SN 0006-9248
EI 1336-0345
J9 BRATISL MED J
JI Bratisl. Med. J.
PY 2018
VL 119
IS 1
BP 36
EP 40
DI 10.4149/BLL_2018_008
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA FW3BZ
UT WOS:000425181900008
PM 29405729
OA gold
DA 2025-06-11
ER

PT J
AU Nagase, M
   Yoshida, S
   Shibata, S
   Nagase, T
   Gotoda, T
   Ando, K
   Fujita, T
AF Nagase, Miki
   Yoshida, Shigetaka
   Shibata, Shigeru
   Nagase, Takashi
   Gotoda, Takanari
   Ando, Katsuyuki
   Fujita, Toshiro
TI Enhanced aldosterone signaling in the early nephropathy of rats with
   metabolic syndrome: Possible contribution of fat-derived factors
SO JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
LA English
DT Article
ID CHRONIC KIDNEY-DISEASE; PREVENTS DIABETIC-NEPHROPATHY; HYPERTENSIVE
   KOLETSKY RAT; MINERALOCORTICOID RECEPTOR; GLOMERULAR HYPERFILTRATION;
   PODOCYTE INJURY; PROTEIN-KINASE; BLOOD-PRESSURE; RENAL INJURY; MODEL
AB Metabolic syndrome is an important risk factor for proteinuria and chronic kidney disease independent of diabetes and hypertension; however, the underlying mechanisms have not been elucidated. Aldosterone is implicated in target organ injury of obesity-related disorders. This study investigated the role of aldosterone in the early nephropathy of 17-wk-old SHR/NDmcr-cp, a rat model of metabolic syndrome. Proteinuria was prominent in SHR/NDmcr-cp compared with nonobese SHR, which was accompanied by podocyte injury as evidenced by foot process effacement, induction of desmin and attenuation of nephrin. Serum aldosterone level, renal and glomerular expressions of aldosterone effector kinase Sgk1, and oxidative stress markers all were elevated in SHR/NDmcr-cp. Mineralocorticoid receptors were expressed in glomerular podocytes. Eplerenone, a selective aldosterone blocker, effectively improved podocyte damage, proteinuria, Sgk1, and oxidant stress. An antioxidant tempol also alleviated podocyte impairment and proteinuria, along with inhibition of Sgk1. As for the mechanisms of aldosterone excess, visceral adipocytes that were isolated from SHR/NDmcr-cp secreted substances that stimulate aldosterone production in adrenocortical cells. The aldosterone-releasing activity of adipocytes was not inhibited by candesartan. Adipocytes from nonobese SHR did not show such activity. In conclusion, SHR/NDmcr-cp exhibit enhanced aldosterone signaling, podocyte injury, and proteinuria, which are ameliorated by eplerenone or tempol. The data also suggest that adipocyte-derived factors other than angiotensin II might contribute to the aldosterone excess of this model.
C1 Univ Tokyo, Grad Sch Med, Dept Nephrol & Endocrinol, Bunkyo Ku, Tokyo 1138655, Japan.
   Univ Tokyo, Grad Sch Med, Dept Clin & Mol Epidemiol, 22 Century Med & Res Ctr, Tokyo 1138655, Japan.
   Murayama Med Ctr, Natl Hosp Org, Clin Res Ctr, Tokyo, Japan.
C3 University of Tokyo; University of Tokyo
RP Nagase, M (corresponding author), Univ Tokyo, Grad Sch Med, Dept Nephrol & Endocrinol, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1138655, Japan.
EM mnagase-tky@umin.ac.jp
OI Fujita, Toshiro/0000-0001-9141-7060; Shibata,
   Shigeru/0000-0002-6868-0626
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NR 48
TC 218
Z9 226
U1 0
U2 9
PU AMERICAN SOCIETY NEPHROLOGY
PI WASHINGTON
PA 1725 I ST, NW STE 510, WASHINGTON, DC 20006 USA
SN 1046-6673
J9 J AM SOC NEPHROL
JI J. Am. Soc. Nephrol.
PD DEC
PY 2006
VL 17
IS 12
BP 3438
EP 3446
DI 10.1681/ASN.2006080944
PG 9
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 111WD
UT WOS:000242485400021
PM 17082236
OA Bronze
DA 2025-06-11
ER

PT J
AU Carrer, M
   Liu, N
   Grueter, CE
   Williams, AH
   Frisard, MI
   Hulver, MW
   Bassel-Duby, R
   Olson, EN
AF Carrer, Michele
   Liu, Ning
   Grueter, Chad E.
   Williams, Andrew H.
   Frisard, Madlyn I.
   Hulver, Matthew W.
   Bassel-Duby, Rhonda
   Olson, Eric N.
TI Control of mitochondrial metabolism and systemic energy homeostasis by
   microRNAs 378 and 378<SUP>☆</SUP>
SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF
   AMERICA
LA English
DT Article
DE fatty acid oxidation; adipocytes; mitochondrial CO2 production
ID FATTY-ACID-METABOLISM; INSULIN-RESISTANCE; SKELETAL-MUSCLE;
   TRANSCRIPTIONAL REGULATION; OXIDATIVE STRESS; GENE-EXPRESSION;
   DYSFUNCTION; OBESITY; GAMMA; DISEASE
AB Obesity and metabolic syndrome are associated with mitochondrial dysfunction and deranged regulation of metabolic genes. Peroxisome proliferator-activated receptor gamma coactivator 1 beta (PGC-1 beta) is a transcriptional coactivator that regulates metabolism and mitochondrial biogenesis through stimulation of nuclear hormone receptors and other transcription factors. We report that the PGC-1 beta gene encodes two microRNAs (miRNAs), miR-378 and miR-378(star), which counterbalance the metabolic actions of PGC-1 beta. Mice genetically lacking miR-378 and miR-378(star) are resistant to high-fat diet-induced obesity and exhibit enhanced mitochondrial fatty acid metabolism and elevated oxidative capacity of insulin-target tissues. Among the many targets of these miRNAs, carnitine O-acetyltransferase, a mitochondrial enzyme involved in fatty acid metabolism, and MED13, a component of the Mediator complex that controls nuclear hormone receptor activity, are repressed by miR-378 and miR-378(star), respectively, and are elevated in the livers of miR-378/378(star) KO mice. Consistent with these targets as contributors to the metabolic actions of miR-378 and miR-378(star), previous studies have implicated carnitine O-acetyltransferase and MED13 in metabolic syndrome and obesity. Our findings identify miR-378 and miR-378(star) as integral components of a regulatory circuit that functions under conditions of metabolic stress to control systemic energy homeostasis and the overall oxidative capacity of insulin target tissues. Thus, these miRNAs provide potential targets for pharmacologic intervention in obesity and metabolic syndrome.
C1 [Carrer, Michele; Liu, Ning; Grueter, Chad E.; Williams, Andrew H.; Bassel-Duby, Rhonda; Olson, Eric N.] Univ Texas SW Med Ctr Dallas, Dept Mol Biol, Dallas, TX 75390 USA.
   [Frisard, Madlyn I.; Hulver, Matthew W.] Virginia Tech Univ, Dept Human Nutr Foods & Exercise, Blacksburg, VA 24061 USA.
C3 University of Texas System; University of Texas Southwestern Medical
   Center Dallas; Virginia Polytechnic Institute & State University
RP Olson, EN (corresponding author), Univ Texas SW Med Ctr Dallas, Dept Mol Biol, Dallas, TX 75390 USA.
EM Eric.Olson@utsouthwestern.edu
RI Bassel-Duby, Rhonda/HJP-5742-2023; Olson, Eric/B-4391-2013
OI Carrer, Michele/0000-0002-6464-9584; Bassel-Duby,
   Rhonda/0000-0001-7568-410X; Olson, Eric N./0000-0003-1151-8262; Grueter,
   Chad/0000-0001-8950-742X
FU American Heart Association; National Institutes of Health; Robert A.
   Welch Foundation [I-0025]; Jon Holden DeHaan Foundation; Donald W.
   Reynolds Center for Clinical Cardiovascular Research; Fondation Leducq
   TransAtlantic Network of Excellence in Cardiovascular Research Program;
   Cancer Prevention and Research Institute of Texas
FX We thank Steven Kliewer, Michael Haberland, Douglas Millay, Craig
   Malloy, Viviana Moresi, and James A. Richardson for insightful
   discussions; Ryan McMillan, Cheryl Nolen and John McAnally for technical
   support; and Jose Cabrera for graphics. M.C. was supported by a
   Predoctoral Fellowship from the American Heart Association. Work in the
   laboratory of Eric Olson was supported by grants from the National
   Institutes of Health, Robert A. Welch Foundation (Grant I-0025),
   American Heart Association, Jon Holden DeHaan Foundation, Donald W.
   Reynolds Center for Clinical Cardiovascular Research, Fondation Leducq
   TransAtlantic Network of Excellence in Cardiovascular Research Program,
   and Cancer Prevention and Research Institute of Texas.
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NR 51
TC 246
Z9 273
U1 1
U2 37
PU NATL ACAD SCIENCES
PI WASHINGTON
PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA
SN 0027-8424
J9 P NATL ACAD SCI USA
JI Proc. Natl. Acad. Sci. U. S. A.
PD SEP 18
PY 2012
VL 109
IS 38
BP 15330
EP 15335
DI 10.1073/pnas.1207605109
PG 6
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 012BS
UT WOS:000309211000056
PM 22949648
OA Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Atteia, HH
   Ahmed, SF
   Askar, ME
   Sakr, AT
AF Atteia, Hebatallah Husseini
   Ahmed, Salwa Fares
   Askar, Mervat El-Sayed
   Sakr, Amr Tawfik
TI Utilizing a Combination of Supplements Comprising Boric Acid, Magnesium,
   Vitamin D3, and Extra Virgin Olive Oil to Improve Metabolism in
   Menopausal Ovariectomized Rats
SO BIOLOGICAL TRACE ELEMENT RESEARCH
LA English
DT Article; Early Access
DE Dyslipidemia; Inflammation; Insulin signaling; Menopause; Metabolic
   syndrome
ID TUMOR-NECROSIS-FACTOR; C-REACTIVE PROTEIN; BORON-CONTAINING COMPOUNDS;
   SERUM-LIPID PROFILES; DOUBLE-BLIND; BLOOD-PRESSURE; NORMAL-WEIGHT;
   RISK-FACTORS; POSTMENOPAUSAL WOMEN; DIETARY MAGNESIUM
AB Metabolic syndrome during menopause can lead to diabetes, cardiovascular problems, and increased mortality rates. Hormone replacement therapy is recommended to manage climacteric complications, but it has serious adverse effects. This study, therefore, investigated the potential of supplementing some minerals, vitamins, and natural products like boric acid, magnesium, vitamin D3, and extra virgin olive oil on metabolic status of menopausal ovariectomized rats. Fourty-two female adult rats were randomly assigned to seven groups: a) Sham Control, b) Ovariectomized Control, c) Ovariectomized + Boric acid, d) Ovariectomized + Magnesium, e) Ovariectomized + Vitamin D3, f) Ovariectomized + Extra virgin olive oil, and g) Ovariectomized + Combined treatment groups. Serum inflammatory and oxidative stress markers, serum lipogram pattern, hepatic triglycerides, body weight, fasting blood glucose, serum insulin, leptin, and adiponectin, as well as hepatic insulin signaling cascade, IRS1/pAKT/GLUT4 were measured in each group to assess metabolic function. Results revealed a significant improvement in inflammation, oxidative stress, and metabolic parameters by individual and concomitant treating ovariectomized rats with boric acid, magnesium, vitamin D3, and extra virgin olive oil. Interestingly, the concurrent use of these supplements displayed a better impact than individual use, suggesting their valuable therapeutic potential for managing metabolic syndrome in menopausal women. However, the necessity of all four supplements for optimal therapeutic effects remains unsubstantiated.
C1 [Atteia, Hebatallah Husseini] Univ Tabuk, Fac Pharm, Dept Pharmaceut Chem, Tabuk, Saudi Arabia.
   [Ahmed, Salwa Fares] Univ Tabuk, Fac Med, Dept Anat, Tabuk, Saudi Arabia.
   [Askar, Mervat El-Sayed] Zagazig Univ, Fac Pharm, Dept Biochem, Zagazig 44519, Egypt.
   [Sakr, Amr Tawfik] Univ Sadat City USC, Fac Pharm, Dept Biochem, Menoufia, Egypt.
C3 University of Tabuk; University of Tabuk; Egyptian Knowledge Bank (EKB);
   Zagazig University; Egyptian Knowledge Bank (EKB); University of Sadat
   City
RP Atteia, HH (corresponding author), Univ Tabuk, Fac Pharm, Dept Pharmaceut Chem, Tabuk, Saudi Arabia.
EM hatteia@ut.edu.sa
RI Ahmed, Salwa/LCE-4091-2024; Atteia, Hebatallah/AFS-3313-2022
FU the Deanship of Scientific Research at the University of Tabuk in Saudi
   Arabia [0027-1444-S]; Deanship of Research and Graduate Studies at
   University of Tabuk
FX The authors extend their appreciation to the Deanship of Research and
   Graduate Studies at University of Tabuk for funding this work through
   Research no. 0027-1444-S.
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   Zheng XH, 2016, EXP THER MED, V11, P1881, DOI 10.3892/etm.2016.3138
NR 154
TC 0
Z9 0
U1 6
U2 6
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0163-4984
EI 1559-0720
J9 BIOL TRACE ELEM RES
JI Biol. Trace Elem. Res.
PD 2024 DEC 28
PY 2024
DI 10.1007/s12011-024-04476-y
EA DEC 2024
PG 16
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA Q5N0B
UT WOS:001385131500001
PM 39731655
DA 2025-06-11
ER

PT J
AU Aursulesei, V
   Bulughiana, S
   Stoica, BA
   Anisie, E
AF Aursulesei, Viviana
   Bulughiana, Siminela
   Stoica, Bogdan Alexandru
   Anisie, Ecaterina
TI Circulating Chemerin, Oxidative Stress, Inflammation and Insulin
   Resistance in Morbid Obesity
SO REVISTA DE CHIMIE
LA English
DT Article
DE chemerin; oxidative stress; inflammation; insulin resistance
ID ADIPOSE-TISSUE; METABOLIC SYNDROME; FATTY LIVER; WEIGHT-LOSS;
   ADIPOKINES; ASSOCIATION; MARKERS; PLASMA; ROLES
AB Chemerin is a relatively novel adipokine with controversial pathophysiological role in obesity. Our study aimed to investigate the relationship of serum chemerin level with inflammation, oxidative stress and insulin resistance in morbidly obese subjects. Circulating chemerin was an independent predictor of TNF-Q level, superoxide dismutase activity and lipid peroxidation, but no relation with insulin resistance could be sustained. Taken together chemerin could be a marker of dysfunctional adipose tissue, but its serum level does not reflect properly the metabolic phenotype in morbid obesity.
C1 [Aursulesei, Viviana] Grigore T Popa Univ Med & Pharm, Fac Med, Med Dept 1, 16 Univ Str, Iasi 700115, Romania.
   [Aursulesei, Viviana; Bulughiana, Siminela] Sf Spiridon Emergency Dist Clin Hosp, Dept Cardiol, 1 Independenei Sq, Iasi 700111, Romania.
   [Stoica, Bogdan Alexandru] Grigore T Popa Univ Med & Pharm, Fac Med, Dept Biochem, 16 Univ Str, Iasi 700115, Romania.
   [Anisie, Ecaterina] Sf Spiridon Emergency Dist Clin Hosp, Immunol & Genet Lab, 1 Independenei Sq, Iasi 700111, Romania.
C3 Grigore T Popa University of Medicine & Pharmacy; Grigore T Popa
   University of Medicine & Pharmacy
RP Aursulesei, V (corresponding author), Grigore T Popa Univ Med & Pharm, Fac Med, Med Dept 1, 16 Univ Str, Iasi 700115, Romania.; Aursulesei, V (corresponding author), Sf Spiridon Emergency Dist Clin Hosp, Dept Cardiol, 1 Independenei Sq, Iasi 700111, Romania.
EM aursuleseiv@yahoo.com
RI Stoica, Bogdan/C-6418-2012; ONOFREI AURSULESEI, VIVIANA/AGY-3366-2022
OI ONOFREI AURSULESEI, VIVIANA/0000-0002-2762-0918
FU Grigore T. Popa University of Medicine and Pharmacy [31583]
FX This research was financed by the Grigore T. Popa University of Medicine
   and Pharmacy by contract no. 31583/23.12.2015.
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NR 35
TC 8
Z9 8
U1 0
U2 5
PU REVISTA CHIMIE SRL
PI BUCURESTI
PA CALES PLEVNEI NR 139A, SECTOR 6, BUCURESTI, ROMANIA
SN 0034-7752
J9 REV CHIM-BUCHAREST
JI Rev. Chim.
PD MAY
PY 2017
VL 68
IS 5
BP 1014
EP 1018
PG 5
WC Chemistry, Multidisciplinary; Engineering, Chemical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Engineering
GA FB0DY
UT WOS:000405816300026
DA 2025-06-11
ER

PT J
AU Chade, AR
   Lerman, A
   Lerman, LO
AF Chade, AR
   Lerman, A
   Lerman, LO
TI Kidney in early atherosclerosis
SO HYPERTENSION
LA English
DT Review
DE kidney; atherosclerosis; oxidative stress; fibrosis
ID LOW-DENSITY-LIPOPROTEIN; CARDIOVASCULAR-DISEASE RISK; GLYCATION
   END-PRODUCTS; CHRONIC-RENAL-FAILURE; 3RD NATIONAL-HEALTH; C-REACTIVE
   PROTEIN; OXIDATIVE STRESS; METABOLIC SYNDROME; INCREASED PREVALENCE;
   MECHANICAL STRETCH
AB Atherosclerosis represents one of the major causes of premature death in the United States today, and it is frequently associated with, exacerbates, and is aggravated by chronic kidney disease (CKD). Atherosclerosis integrates the response to a number of insults, and consequently, the accelerated atherosclerosis found in CKD patients is associated with activation of a variety of humoral and tissue mechanisms. Hypertension, diabetes, dyslipidemia, obesity, metabolic syndrome, and additional nontraditional risk factors can damage the kidney directly and by promoting intrarenal atherogenesis, even in the absence of obstructive lesions in the renal artery. Evidence indicates that increased oxidative stress and inflammation may mediate a large part of the effects of risk factors on the kidney. In turn, progressive deterioration of renal function in CKD may lead to dyslipidemia or accumulation of uremic toxins, which can induce production of free radicals and activate proinflammatory and fibrogenic factors, leading to vascular endothelial cell dysfunction and injury, and favoring development of atherosclerosis. Therefore, the kidney can be a villain or a victim during atherogenesis. The purpose of this review is to provide new insights into the mechanisms by which atherogenic factors may instigate early renal injury.
C1 Mayo Clin, Coll Med, Div Nephrol & Hypertens, Dept Internal Med, Rochester, MN 55905 USA.
   Mayo Clin, Div Cardiovasc Dis, Rochester, MN USA.
C3 Mayo Clinic; Mayo Clinic
RP Mayo Clin, Coll Med, Div Nephrol & Hypertens, Dept Internal Med, Rochester, MN 55905 USA.
EM Lerman.Lilach@Mayo.Edu
RI Lerman, Lilach/M-4962-2017
FU NHLBI NIH HHS [HL-77131, K24-HL69840, HL-63282] Funding Source: Medline
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NR 110
TC 139
Z9 152
U1 1
U2 8
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0194-911X
EI 1524-4563
J9 HYPERTENSION
JI Hypertension
PD JUN
PY 2005
VL 45
IS 6
BP 1042
EP 1049
DI 10.1161/01.HYP.0000167121.14254.a0
PG 8
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 930DS
UT WOS:000229396600003
PM 15897370
DA 2025-06-11
ER

PT J
AU Lee, HS
   Park, T
AF Lee, Ho-Sun
   Park, Taesung
TI Pathway-Driven Approaches of Interaction between Oxidative Balance and
   Genetic Polymorphism on Metabolic Syndrome
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Article
ID GENOME-WIDE ASSOCIATION; C-REACTIVE PROTEIN; ENVIRONMENT INTERACTIONS;
   CARDIOVASCULAR-DISEASE; COLORECTAL ADENOMA; STRESS; INFLAMMATION;
   CANCER; SCORE; RISK
AB Despite evidences of association between basic redox biology and metabolic syndrome (MetS), few studies have evaluated indices that account for multiple oxidative effectors for MetS. Oxidative balance score (OBS) has indicated the role of oxidative stress in chronic disease pathophysiology. In this study, we evaluated OBS as an oxidative balance indicator for estimating risk of MetS with 6414 study participants. OBS is a multiple exogenous factor score for development of disease; therefore, we investigated interplay between oxidative balance and genetic variation for development of MetS focusing on biological pathways by using gene-setenrichment analysis. As a result, participants in the highest quartile of OBS were less likely to be at risk for MetS than those in the lowest quartile. In addition, persons in the highest quartile of OBS had the lowest level of inflammatory markers including Creactive protein andWBC. With GWAS-based pathway analysis, we found that VEGF signaling pathway, glutathione metabolism, and Rac-1 pathway were significantly enriched biological pathways involved with OBS on MetS. These findings suggested that mechanism of angiogenesis, oxidative stress, and inflammation can be involved in interaction between OBS and genetic variation on risk of MetS.
C1 [Park, Taesung] Seoul Natl Univ, Interdisciplinary Program Bioinformat, Seoul 152742, South Korea.
   Seoul Natl Univ, Dept Stat, Seoul 152742, South Korea.
C3 Seoul National University (SNU); Seoul National University (SNU)
RP Park, T (corresponding author), Seoul Natl Univ, Interdisciplinary Program Bioinformat, Seoul 152742, South Korea.
EM tspark@stats.snu.ac.kr
RI Lee, Ho-Sun/AAD-6112-2019
OI Park, Taesung/0000-0002-8294-590X; Lee, Ho-Sun/0000-0003-2864-015X
FU Bio-Synergy Research Project of the Ministry of Science, ICT and Future
   Planning through the National Research Foundation [2013M3A9C4078158];
   National Research Foundation of Korea [22A20151713442] Funding Source:
   Korea Institute of Science & Technology Information (KISTI), National
   Science & Technology Information Service (NTIS)
FX This work was supported by the Bio-Synergy Research Project of the
   Ministry of Science, ICT and Future Planning through the National
   Research Foundation (2013M3A9C4078158).
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NR 51
TC 31
Z9 35
U1 0
U2 4
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PY 2017
VL 2017
AR 6873197
DI 10.1155/2017/6873197
PG 9
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA EK7RF
UT WOS:000394122200001
PM 28191276
OA Green Submitted, Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Lasker, S
   Rahman, MM
   Parvez, F
   Zamila, M
   Miah, P
   Nahar, K
   Kabir, F
   Sharmin, SB
   Subhan, N
   Ahsan, GU
   Alam, MA
AF Lasker, Shoumen
   Rahman, Md Mizanur
   Parvez, Faisal
   Zamila, Mushfera
   Miah, Pintu
   Nahar, Kamrun
   Kabir, Fariha
   Sharmin, Surovi Binte
   Subhan, Nusrat
   Ahsan, Gias U.
   Alam, Md Ashraful
TI High-fat diet-induced metabolic syndrome and oxidative stress in obese
   rats are ameliorated by yogurt supplementation
SO SCIENTIFIC REPORTS
LA English
DT Article
ID LACTIC-ACID BACTERIA; LACTOBACILLUS-ACIDOPHILUS; INSULIN-RESISTANCE; GUT
   MICROBIOTA; LIVER; CHOLESTEROL; PROBIOTICS; PRODUCTS; CONSUMPTION;
   CHILDREN
AB The main objective of this experiment was to determine the effects of yogurt supplementation on fat deposition, oxidative stress, inflammation and fibrosis in the liver of rats with high-fat (HF) diet-induced obesity. Male Wistar rats were used in this study and were separated into the following four different groups: the control, control + yogurt, high fat and high fat + yogurt groups. The high fat groups received a HF diet for eight weeks. A 5% yogurt (w/w) supplement was also provided to rats fed the HF diet. Yogurt supplementation prevented glucose intolerance and normalized liver-specific enzyme activities in the HF diet-fed rats. Yogurt supplementation also significantly reduced the levels of oxidative stress markers in the plasma and liver of HF diet-fed rats. Moreover, inflammatory cell infiltration, collagen deposition and fibrosis in the liver of HF diet-fed rats were also prevented by yogurt supplementation. Furthermore, yogurt supplementation normalized the intestinal lining and brush border in HF diet-fed rats. This study suggests that yogurt supplementation potentially represents an alternative therapy for the prevention of metabolic syndrome in HF diet-fed rats.
C1 [Lasker, Shoumen; Rahman, Md Mizanur; Parvez, Faisal; Zamila, Mushfera; Miah, Pintu; Nahar, Kamrun; Kabir, Fariha; Sharmin, Surovi Binte; Subhan, Nusrat; Alam, Md Ashraful] North South Univ, Dept Pharmaceut Sci, Dhaka 1219, Bangladesh.
   [Ahsan, Gias U.] North South Univ, Dept Publ Hlth, Sch Hlth & Life Sci, Dhaka 1219, Bangladesh.
C3 North South University (NSU); North South University (NSU)
RP Alam, MA (corresponding author), North South Univ, Dept Pharmaceut Sci, Dhaka 1219, Bangladesh.; Ahsan, GU (corresponding author), North South Univ, Dept Publ Hlth, Sch Hlth & Life Sci, Dhaka 1219, Bangladesh.
EM gias.ahsan@northsouth.edu; sonaliagun@yahoo.com
RI Nahar, Dr.Kamrun/JFS-9212-2023; Mohona, Surovi/AAG-4129-2020; Ahsan,
   Gias/AAN-8794-2020; Alam, Ashraful/G-1964-2014; Rahman, Md
   Mizanur/AAC-7666-2019
OI Miah, Pintu/0000-0002-8535-7214; Rahman, Md Mizanur/0000-0002-7178-7977;
   Mohona, Surovi Binte Sharmin/0000-0002-0360-9714; Alam, Md
   Ashraful/0000-0001-7596-5868; Kabir, Fariha/0000-0001-6412-5257; Zamila,
   Mushfera/0000-0002-2904-9436
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NR 59
TC 162
Z9 171
U1 3
U2 42
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD DEC 27
PY 2019
VL 9
AR 20026
DI 10.1038/s41598-019-56538-0
PG 15
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA KF5XV
UT WOS:000509315700029
PM 31882854
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Kayikcioglu, M
   Payzin, S
   Yavuzgil, O
   Kultursay, H
   Can, LH
   Soydan, I
AF Kayikcioglu, M
   Payzin, S
   Yavuzgil, O
   Kultursay, H
   Can, LH
   Soydan, I
TI Benefits of statin treatment in cardiac syndrome-X
SO EUROPEAN HEART JOURNAL
LA English
DT Article; Proceedings Paper
CT 24th Congress of the European-Society-of-Cardiology
CY AUG 31-SEP 04, 2002
CL BERLIN, GERMANY
SP European Soc Cardiol
DE endothelium; inflammation; cardiac syndrome-X; exercise; pravastatin
ID NORMAL CORONARY ARTERIOGRAMS; NITRIC-OXIDE SYNTHASE; ANGINA-PECTORIS;
   ENDOTHELIAL DYSFUNCTION; 3-HYDROXY-3-METHYLGLUTARYL-COA REDUCTASE;
   PRAVASTATIN SODIUM; BLOOD RHEOLOGY; CHEST PAIN; CHOLESTEROL;
   VASODILATION
AB Aims The pathophysiological mechanism in cardiac syndrome-X (anginal chest pain, positive exercise test, and angiographically normal coronary arteries) has been suggested as an impairment in normal endothelial function of the coronary microvasculature, resulting in inadequate flow reserve. The aim of this study was to determine whether statins with proven beneficial effects on endothelium, have any effect on endothelial functions and exercise induced ischaemia in cardiac syndrome-X.
   Methods and results Study population consisted of prospectively enrolled 40 patients with cardiac syndrome-X. Patients with left ventricular hypertrophy, hypertension, diabetes mellitus, and LDL levels greater than or equal to160 mg/dl were excluded. Half of the patients received pravastatin (40 mg/day) for 3 months irrespective of their lipid values, according to a single-blind, randomized, placebo-controlled design. Endothelial functions were assessed with high-resolution vascular ultrasound, which measured the brachial artery flow mediated dilatation (FMD). Lipid measurements, symptom limited exercise tests and vascular ultrasound images were obtained before and at the end of 3 months. After the treatment, FMD improved significantly in pravastatin group. Exercise duration, and time to 1 mm-ST depression were significantly prolonged after statin therapy. Ischaemic symptoms and ECG findings during exercise test disappeared completely in 5 (26%) patients in the statin group. However, there were no significant changes in FMD and exercise parameters in placebo group.
   Conclusions Statin therapy resulted in beneficial effects on both exercise induced ischaemia and FMD in cardiac syndrome-X. The mechanism of this beneficial effect is probably the result of improvement in endothelial functions. (C) 2003 The European Society of Cardiology. Published by Elsevier Ltd. All rights reserved.
C1 Ege Univ, Sch Med, Dept Cardiol, Izmir, Turkey.
C3 Ege University
RP Kayikcioglu, M (corresponding author), Ege Univ, Sch Med, Dept Cardiol, Izmir, Turkey.
RI KAYIKCIOGLU, Meral/AAH-6687-2020
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NR 28
TC 133
Z9 144
U1 0
U2 12
PU W B SAUNDERS CO LTD
PI LONDON
PA 32 JAMESTOWN RD, LONDON NW1 7BY, ENGLAND
SN 0195-668X
J9 EUR HEART J
JI Eur. Heart J.
PD NOV
PY 2003
VL 24
IS 22
BP 1999
EP 2005
DI 10.1016/S0195-668X(03)00478-0
PG 7
WC Cardiac & Cardiovascular Systems
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 745RN
UT WOS:000186702000004
PM 14613735
OA Bronze
DA 2025-06-11
ER

PT J
AU Saatcioglu, O
   Kalkan, M
   Fistikci, N
   Erek, S
   Kilic, KC
AF Saatcioglu, Omer
   Kalkan, Murat
   Fistikci, Nurhan
   Erek, Sakire
   Kilic, Kasim Candas
TI Relationship Between Metabolic Syndrome and Clinical Features, and Its
   Personal-Social Performance in Patients with Schizophrenia
SO PSYCHIATRIC QUARTERLY
LA English
DT Article
DE Schizophrenia; Metabolic syndrome; Antipsychotics; Functionality
ID QUALITY-OF-LIFE; ATYPICAL ANTIPSYCHOTICS; GLUCOSE-METABOLISM;
   DIABETES-MELLITUS; HIGH PREVALENCE; WEIGHT-GAIN; SCALE; RISK;
   DETERMINANTS; RELIABILITY
AB The aim of this study was to evaluate the metabolic syndrome (MS) criteria and also to investigate the effects of MS on medical treatment, clinical course and personal and social performance in patients with schizophrenia. One hundred-sixteen patients with schizophrenia were included in the study. Measurements of MS were calculated in all patients. Brief Psychiatric Rating Scale, Scale for the Assessment of Positive Symptoms, Scale for the Assessment of Negative Symptoms, Calgary Depression Scale for Schizophrenia, Personal and Social Performance Scale (PSP) were applied. The frequency of MS according to IDF criteria was 42.2 % among the patients. There was no significant difference between patients with and without MS in terms of age. The ratios of MS were 62.5 % for the group taking typical and atypical antipsychotics together and 35.7 % for the group taking two or more atypical antipsychotics together. The duration of disorder in patients with MS was higher than those without MS. Furthermore there was no significant difference between the schizophrenic patients with and without MS, in terms of PSP scores. Our findings showed that the duration of illness, high scores of BMI, use of clozapine or concurrent use of typical and atypical antipsychotics, depressive and negative symptoms of schizophrenia were significant risk factors for the development of MS.
C1 [Kalkan, Murat; Fistikci, Nurhan; Erek, Sakire] Bakirkoy Prof Dr Mazhar Osman Ruh Sagligi & Sinir, Bakirkoy Res & Training Hosp Psychiat Neurol & Ne, TR-34147 Istanbul, Turkey.
   [Kilic, Kasim Candas] Ankara Numune Training & Res Hosp, Psychiat Clin, TR-06100 Ankara, Turkey.
   [Saatcioglu, Omer] Isik Univ, Dept Psychol, TR-34398 Istanbul, Turkey.
C3 Istanbul Bakirkoy Mental Health & Neurology Training & Research
   Hospital; Ankara Numune Training & Research Hospital; Isik University
RP Fistikci, N (corresponding author), Bakirkoy Prof Dr Mazhar Osman Ruh Sagligi & Sinir, Bakirkoy Res & Training Hosp Psychiat Neurol & Ne, TR-34147 Istanbul, Turkey.
EM osaatcioglu@yahoo.com; kaiserkalkan@yahoo.com; nurhanfistikci@gmail.com;
   ereks@yahoo.com; corneum7@yahoo.com
RI Saatcioglu, Omer/ABF-8318-2020
OI Saatcioglu, Omer/0000-0002-5825-9029
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NR 62
TC 7
Z9 7
U1 0
U2 22
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0033-2720
EI 1573-6709
J9 PSYCHIAT QUART
JI Psychiatr. Q.
PD JUN
PY 2016
VL 87
IS 2
BP 265
EP 280
DI 10.1007/s11126-015-9384-0
PG 16
WC Psychiatry
WE Social Science Citation Index (SSCI)
SC Psychiatry
GA DK1QL
UT WOS:000374688400006
PM 26174109
DA 2025-06-11
ER

PT J
AU Liu, L
   Huang, X
   Gao, JL
   Guo, YS
   Di, YQ
   Sun, SS
   Deng, XL
   Cao, J
AF Liu, Lu
   Huang, Xin
   Gao, Jinliao
   Guo, Yusong
   Di, Yanqi
   Sun, Shasha
   Deng, Xinli
   Cao, Jian
TI Improved endogenous epoxyeicosatrienoic acid production mends heart
   function via increased PGC 1α-mitochondrial functions in metabolic
   syndrome
SO JOURNAL OF PHARMACOLOGICAL SCIENCES
LA English
DT Article
DE Epoxyeicoastrienoic acids; PGC-1 alpha; Heme oxygenase-1; Mitochondrial
   function; Metabolic syndrome
ID SPONTANEOUSLY HYPERTENSIVE-RATS; SOLUBLE EPOXIDE HYDROLASE; HEME
   OXYGENASE-1; CARDIAC DYSFUNCTION; BLOOD-PRESSURE; UP-REGULATION;
   ADIPONECTIN; ADIPOCYTES; MODEL; HO-1
AB Metabolic syndrome (MS) is a combination of symptoms characterized by central obesity, hypertension, hyperglycemia, and hyperlipidemia, which together increase the risk of heart disease, stroke and diabetes. In our study, we hypothesized that an EET-agonist (AUDA) would increase expression of PGC 1 alpha and improve mitochondrial and endothelial functions, resulting in improved heart function in a rat model of MS. To investigate this, rats were randomly divided into four groups: 1) Control; 2) MS thorn ABCT; 3) MS thorn AUDA; and 4) MS thorn AUDA thorn SnMP. MS rats were fed a high-fructose diet for 16 weeks and developed elevated inflammatory mediators, oxidative stress, and significant decreases in fractional shortening and hemodynamic parameters, indicating cardiac dysfunction. Histology revealed myocardial fibrosis and myocyte hypertrophy. AUDA improves mitochondrial function proven by increase in mt copy number and ATP production and significantly increased expression of PGC-1 alpha and HO-1 in the rats and normalization of inflammatory cytokines, oxidative stress, and improves in cardiac function and myocardial fibrosis. These benefits were reversed by SnMP. Furthermore, AUDA increases eNOS but decreases iNOS expression which improved endothelial function. We therefore demonstrate that endogenous EET upregulation plays a novel role in protecting the heart from MS by regulating mitochondrial and endothelial function. (c) 2018 The Authors. Production and hosting by Elsevier B.V. on behalf of Japanese Pharmacological Society.
C1 [Liu, Lu; Huang, Xin; Gao, Jinliao; Guo, Yusong; Di, Yanqi; Sun, Shasha; Cao, Jian] Chinese Peoples Liberat Army Gen Hosp, Nanlou Div, Dept Geriatr Cardiol, Natl Clin Res Ctr Geriatr Dis, Beijing 100853, Peoples R China.
   [Deng, Xinli] Chinese Peoples Liberat Army Gen Hosp, Nanlou Lab, Med Dept, Beijing 100853, Peoples R China.
C3 Chinese People's Liberation Army General Hospital; Chinese People's
   Liberation Army General Hospital
RP Cao, J (corresponding author), Chinese Peoples Liberat Army Gen Hosp, Nanlou Div, Dept Geriatr Cardiol, Natl Clin Res Ctr Geriatr Dis, Beijing 100853, Peoples R China.; Deng, XL (corresponding author), Chinese Peoples Liberat Army Gen Hosp, Nanlou Lab, Med Dept, Beijing 100853, Peoples R China.
EM bjdxl@163.com; calvin301@163.com
OI Cao, Jian/0000-0001-6728-4587
FU National Natural Science Foundation of China [81270154]; Military Health
   Care Project Foundation [16BJZ15]
FX This work was supported by the National Natural Science Foundation of
   China (81270154) and Military Health Care Project Foundation (16BJZ15).
CR Abraham NG, 2016, TRENDS PHARMACOL SCI, V37, P17, DOI 10.1016/j.tips.2015.09.003
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NR 31
TC 13
Z9 16
U1 0
U2 3
PU JAPANESE PHARMACOLOGICAL SOC
PI KYOTO
PA EDITORIAL OFF, KANTOHYA BLDG GOKOMACHI-EBISUGAWA NAKAGYO-KU, KYOTO, 604,
   JAPAN
SN 1347-8613
EI 1347-8648
J9 J PHARMACOL SCI
JI J. Pharmacol. Sci.
PD OCT
PY 2018
VL 138
IS 2
BP 138
EP 145
DI 10.1016/j.jphs.2018.09.010
PG 8
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA HA7GM
UT WOS:000450449300007
PM 30342783
OA gold
DA 2025-06-11
ER

PT J
AU Walburg, FS
   van Meijel, B
   Hoekstra, T
   Kol, J
   Pape, LM
   de Joode, JW
   van Tulder, M
   Adriaanse, M
AF Walburg, Florine Sanna
   van Meijel, Berno
   Hoekstra, Trynke
   Kol, Jelle
   Pape, Laura Michelle
   de Joode, Johanna Willemina
   van Tulder, Maurits
   Adriaanse, Marcel
TI Effectiveness of a Lifestyle Intervention for People With a Severe
   Mental Illness in Dutch Outpatient Mental Health Care A Randomized
   Clinical Trial
SO JAMA PSYCHIATRY
LA English
DT Article
ID WEIGHT-LOSS; SCHIZOPHRENIA; RISK; DISORDERS; DIET
AB IMPORTANCE People with a severe mental illness (SMI) have a life expectancy reduced by 10 to 20 years compared with the general population, primarily attributable to cardiometabolic disorders. Lifestyle interventions for people with SMI can improve health and reduce cardiometabolic risk.
   OBJECTIVE To evaluate the effectiveness of a group-based lifestyle intervention among people with SMI in outpatient treatment settings compared with treatment as usual (TAU).
   DESIGN, SETTING, AND PARTICIPANTS The Severe Mental Illness Lifestyle Evaluation (SMILE) study is a pragmatic cluster randomized clinical trial performed in 8 mental health care centers with 21 flexible assertive community treatment teams in the Netherlands. Inclusion criteria were SMI, age of 18 years or older, and body mass index (calculated as weight in kilograms divided by height in meters squared) of 27 or greater. Data were collected from January 2018 to February 2020, and data were analyzed from September 2020 to February 2023.
   INTERVENTIONS Weekly 2-hour group sessions for 6 months followed by monthly 2-hour group sessions for another 6 months, delivered by trained mental health care workers. The intervention targeted overall lifestyle changes, emphasizing establishing a healthy diet and promoting physical activity. TAU (control) did not include structured interventions or advice on lifestyle.
   MAIN OUTCOMES AND MEASURES Crude and adjusted linear mixed models and multivariable logistic regression analyses were performed. The main outcome was body weight change. Secondary outcomes included changes in body mass index, blood pressure, lipid profiles, fasting glucose level, quality of life, self-management ability, and lifestyle behaviors (physical activity and health, mental health, nutrition, and sleep).
   RESULTS The study population included 11 lifestyle intervention teams (126 participants) and 10 TAU teams (98 participants). Of 224 included patients, 137 (61.2%) were female, and the mean (SD) age was 47.6 (11.1) years. From baseline to 12 months, participants in the lifestyle intervention group lost 3.3 kg (95% CI, -6.2 to -0.4) more than those in the control group. In the lifestyle intervention group, people with high attendance rates lost more weight than participants with medium and low rates (mean [SD] weight loss: high, -4.9 [8.1] kg; medium, -0.2 [7.8] kg; low, 0.8 [8.3] kg). Only small or no changes were found for secondary outcomes.
   CONCLUSIONS AND RELEVANCE In this trial, the lifestyle intervention significantly reduced weight from baseline to 12 months in overweight and obese adults with SMI. Tailoring lifestyle interventions and increasing attendance rates might be beneficial for people with SMI.
C1 [Walburg, Florine Sanna; Hoekstra, Trynke; Kol, Jelle; Pape, Laura Michelle; de Joode, Johanna Willemina; Adriaanse, Marcel] Vrije Univ Amsterdam, Amsterdam Publ Hlth Res Inst, Dept Hlth Sci, Amsterdam, Netherlands.
   [van Meijel, Berno] Inholland Univ Appl Sci, Dept Hlth Sports & Welfare, Mental Hlth Nursing Res Grp, Amsterdam, Netherlands.
   [van Meijel, Berno] Amsterdam UMC VUmc, Dept Psychiat, Amsterdam Publ Hlth Res Inst, Amsterdam, Netherlands.
   [van Meijel, Berno] Parnassia Acad, Parnassia Psychiat Inst, The Hague, Netherlands.
   [van Tulder, Maurits] Vrije Univ Amsterdam, Fac Behav & Movement Sci, Dept Clin Neuro & Dev Psychol, Amsterdam, Netherlands.
C3 Vrije Universiteit Amsterdam; Vrije Universiteit Amsterdam; Parnassia
   Psychiatric Institute; Vrije Universiteit Amsterdam
RP Walburg, FS (corresponding author), Vrije Univ Amsterdam, Dept Hlth Sci, Amsterdam Publ Hlth Res Inst, De Boelelaan 1105, NL-1081 HV Amsterdam, Netherlands.
EM florine.walburg@vu.nl
RI Hoekstra, Trynke/AAG-5901-2020; van Tulder, Maurits/AAB-9785-2022;
   Adriaanse, Marieke/AFQ-8371-2022
OI Walburg, F.S./0000-0002-4079-1500; van Tulder,
   Maurits/0000-0002-7589-8471; Adriaanse, Marcel/0000-0002-5085-6662;
   Hoekstra, Trynke/0000-0002-0535-0056
FU Netherlands Organization for Health Research and Development (ZonMW)
   [80-84300-98-72012]
FX This study was funded by grant 80-84300-98-72012 from the Netherlands
   Organization for Health Research and Development (ZonMW).
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NR 42
TC 11
Z9 11
U1 0
U2 7
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 2168-622X
EI 2168-6238
J9 JAMA PSYCHIAT
JI JAMA Psychiatry
PD SEP
PY 2023
VL 80
IS 9
BP 886
EP 894
DI 10.1001/jamapsychiatry.2023.1566
EA JUN 2023
PG 9
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA W8MO9
UT WOS:001020073300003
PM 37342055
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Bogale, SK
   Sarma, H
   Gray, D
   Kelly, M
AF Bogale, Sitotaw Kerie
   Sarma, Haribondhu
   Gray, Darren
   Kelly, Matthew
TI The effectiveness, feasibility, and acceptability of an education
   intervention promoting healthy lifestyle to reduce risk factors for
   metabolic syndrome, among office workers in Ethiopia: A protocol for a
   randomized control trial study
SO PLOS ONE
LA English
DT Article
ID PREVALENCE
AB Background Nowadays, metabolic syndrome has become a major health threat, and affects over one billion people globally. It also plays a great role in the growth of diseases like type 2 diabetes, coronary diseases, stroke, and other chronicity. It increases the risk of cardiovascular disorder and stroke by three to ten times and diabetic mellitus by ten times. The prevalence of metabolic syndrome is increasing globally as a result of epidemiological shift. Low and middle-income countries are facing an increasing burden of metabolic syndrome. There is a need for concerted efforts to modify behavioral risk factors that significantly contribute to the prevalence of the syndrome. This can be done by developing and implementing appropriate interventions that can bring behavior change after testing for effectiveness, feasibility, and acceptability. Thus, this study aims to develop and test the effectiveness, feasibility and acceptability of an education intervention promoting healthy lifestyle to reduce risk factors for metabolic syndrome, among office workers in Ethiopia.Methods and analysis This randomized controlled trial will be implemented with 226 bank employees (age >= 18 years) with metabolic syndrome from government and private banks in Bahir Dar City, Ethiopia. Participants will be randomized to intervention (education) and control (general health advice) groups. The intervention group will be given one-on -one base education about healthy diets, physical exercise, stress management, avoidance of harmful alcohol consumption and smoking cessation by experts on health promotion. Text messages will be sent every two weeks and reading materials will also be provided. Additionally, a review meeting will be held at the 3rd and 6th month of the intervention. The primary outcomes of interest will be change in metabolic parameters (obesity levels, blood pressure, fasting blood glucose, total cholesterol, high density lipoprotein, low density lipoprotein, and triglycerides). Secondary outcomes will be knowledge, attitudes and practice of the participants towards lifestyle and cardiovascular risk factors, feasibility, acceptability, implementation fidelity, and cost-effectiveness of the intervention. Data will be collected at three time points: at baseline, at the 6th month of the intervention and at the end of the intervention (9 months). Generalized linear mixed models will be utilized to compare the desired outcome between the trial arms, after accounting for baseline variations. Cost-benefit analysis and a qualitative process evaluation of the intervention will also be conducted.Discussion This randomized control trial study will provide information on the effectiveness, feasibility, and acceptability of an education intervention promoting healthy lifestyle to reduce risk factors for metabolic syndrome, among office workers in Ethiopia, where the burden of metabolic syndrome is high among office workers.Clinical trial registration This trial has been prospectively registered at the Australian New Zealand Clinical Trials Registry: ACTRN12623000409673p.
C1 [Bogale, Sitotaw Kerie; Sarma, Haribondhu; Gray, Darren; Kelly, Matthew] Australian Natl Univ, Natl Ctr Epidemiol & Populat Hlth, Canberra, ACT, Australia.
   [Bogale, Sitotaw Kerie] Bahir Dar Univ, Coll Med & Hlth Sci, Bahir Dar, Ethiopia.
   [Gray, Darren] QIMR Berghofer Med Res Inst, Populat Hlth Program, Brisbane, Australia.
C3 Australian National University; Bahir Dar University; QIMR Berghofer
   Medical Research Institute
RP Bogale, SK (corresponding author), Australian Natl Univ, Natl Ctr Epidemiol & Populat Hlth, Canberra, ACT, Australia.; Bogale, SK (corresponding author), Bahir Dar Univ, Coll Med & Hlth Sci, Bahir Dar, Ethiopia.
EM Sitotaw.Bogale@anu.edu.au
RI Sarma, Haribondhu/AAG-4817-2020; Kelly, Matthew/ABC-1069-2020
OI Sarma, Haribondhu/0000-0003-1553-8498; Kelly,
   Matthew/0000-0001-7963-2139
FX We express our gratitude to every research participant who will be
   working with us on this project. We also want to express our gratitude
   to the bank managers for granting us permission to collect data in their
   respective bank branches.
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NR 42
TC 0
Z9 0
U1 1
U2 5
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD AUG 30
PY 2024
VL 19
IS 8
AR e0307659
DI 10.1371/journal.pone.0307659
PG 16
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA E6O1P
UT WOS:001304170300003
PM 39213318
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU de Kock, A
   Malan, L
   Potgieter, JC
   Steenekamp, W
   van der Merwe, MT
AF de Kock, A.
   Malan, L.
   Potgieter, J. C.
   Steenekamp, W.
   van der Merwe, M. T.
TI Metabolic Syndrome Indicators and Target Organ Damage in Urban Active
   Coping African and Caucasian Men: The SABPA Study
SO EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
LA English
DT Article
DE coping; endothelial dysfunction; ethnicity; metabolic syndrome
ID STRATEGY INDICATOR; BLOOD-GLUCOSE; DISEASE; RISK; URBANIZATION;
   HYPERTENSION; MORTALITY; THUSA
AB Psychosocial stress relating to an urban environment or acculturation increases the prevalence of metabolic syndrome (MetS). The objectives of this study were firstly to indicate and compare differences regarding appraisal of stress or active coping responses in urban African (n=88) and Caucasian (n=101) male teachers of South Africa, in accord with the prevalence of MetS indicators. And secondly to investigate the extent to which utilisation of active coping responses, together with MetS indicators, predict target organ damage, in these men. The Coping Strategy Indicator determined high and low active coping responses in male teachers from the Sympathetic Activity and Ambulatory Blood Pressure in Africans (SABPA) study. SABPA inclusion and exclusion criteria were used. Additionally, diabetic medication users (n=8), and participants with renal impairment (n=2) or HIV positive (n=13), were excluded. MetS indicators included glucose, triglyceride, high-density lipoprotein cholesterol, blood pressure, and waist circumference, independent of confounders (age, physical activity, gamma glutamyl transferase). Microalbuminuria and carotid intima-media thickness indicated target organ damage. More MetS indicators exceeded the IDF cut-off points in high active coping African men (14.71%) than in their Caucasian counterparts (3.33%), as determined from X-2 analyses. Furthermore, stepwise regressions indicated that more MetS indicators predicted endothelial dysfunction, especially in the high active coping African men. High active coping African men showed more manifestation of MetS, compared to their Caucasian counterparts, and revealed progress towards endothelial dysfunction.
C1 [Potgieter, J. C.] Univ Pretoria, North West Univ, Sch Psychosocial Behav Sci, ZA-0002 Pretoria, South Africa.
   [van der Merwe, M. T.] Univ Pretoria, Bariatr Ctr Excellence, ZA-0002 Pretoria, South Africa.
   [de Kock, A.; Malan, L.] Univ Pretoria, Sch Physiol Nutr & Consumer Sci, Hypertens Africa Res Team HART, ZA-0002 Pretoria, South Africa.
C3 North West University - South Africa; University of Pretoria; University
   of Pretoria; University of Pretoria
RP Malan, L (corresponding author), North West Univ, Private Bag X6001, ZA-2520 Potchefstroom, South Africa.
EM 10060871@nwu.ac.za
RI Malan, Leone/Q-8187-2019; Malan, Leone/D-7203-2014
OI Malan, Leone/0000-0003-3187-2410
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NR 27
TC 4
Z9 4
U1 0
U2 5
PU JOHANN AMBROSIUS BARTH VERLAG MEDIZINVERLAGE HEIDELBERG GMBH
PI STUTTGART
PA RUEDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0947-7349
J9 EXP CLIN ENDOCR DIAB
JI Exp. Clin. Endocrinol. Diabet.
PD MAY
PY 2012
VL 120
IS 5
BP 282
EP 287
DI 10.1055/s-0031-1295472
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism
GA 966UF
UT WOS:000305862200008
PM 22231925
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Ando, H
   Takamura, T
   Matsuzawa-Nagata, N
   Shima, KR
   Nakamura, S
   Kumazaki, M
   Kurita, S
   Misu, H
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   Fukushima, T
   Fujimura, A
   Kaneko, S
AF Ando, Hitoshi
   Takamura, Toshinari
   Matsuzawa-Nagata, Naoto
   Shima, Kosuke R.
   Nakamura, Seiji
   Kumazaki, Masafumi
   Kurita, Seiichiro
   Misu, Hirofumi
   Togawa, Naoyuki
   Fukushima, Tatsunobu
   Fujimura, Akio
   Kaneko, Shuichi
TI The hepatic circadian clock is preserved in a lipid-induced mouse model
   of non-alcoholic steatohepatitis
SO BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
LA English
DT Article
DE Atherogenic diet; Circadian rhythm; Clock gene; Non-alcoholic
   steatohepatitis; Oxidative stress
ID PLASMINOGEN-ACTIVATOR INHIBITOR-1; NECROSIS-FACTOR-ALPHA; HEPATOCYTE
   CELL-LINE; FATTY LIVER-DISEASE; DIETARY RAT MODEL; GENE-EXPRESSION;
   OXIDATIVE STRESS; RECEPTOR EXPRESSION; PERIPHERAL-TISSUES; METABOLIC
   SYNDROME
AB Recent studies have correlated metabolic diseases, such as metabolic syndrome and non-alcoholic fatty liver disease, with the circadian clock. However, whether such metabolic changes per se affect the circadian clock remains controversial. To address this, we investigated the daily mRNA expression profiles of clock genes in the liver of a dietary mouse model of non-alcoholic steatohepatitis (NASH) using a custom-made, high-precision DNA chip. C57BL/6J mice fed an atherogenic diet for 5 weeks developed hypercholesterolemia, oxidative stress, and NASH. DNA chip analyses revealed that the atherogenic diet had a great influence on the mRNA expression of a wide range of genes linked to mitochondrial energy production, redox regulation, and carbohydrate and lipid metabolism. However, the rhythmic mRNA expression of the clock genes in the liver remained intact. Most of the circadianly expressed genes also showed 24-h rhythmicity. These findings Suggest that the biological clock is protected against such a metabolic derangement as NASH. (C) 2009 Elsevier Inc. All rights reserved.
C1 [Ando, Hitoshi; Takamura, Toshinari; Matsuzawa-Nagata, Naoto; Shima, Kosuke R.; Nakamura, Seiji; Kumazaki, Masafumi; Kurita, Seiichiro; Misu, Hirofumi; Kaneko, Shuichi] Kanazawa Univ, Grad Sch Med Sci, Dept Dis Control & Homeostasis, Kanazawa, Ishikawa 9208641, Japan.
   [Fujimura, Akio] Jichi Med Univ, Sch Med, Dept Pharmacol, Div Clin Pharmacol, Shimotsuke, Tochigi 3290498, Japan.
   [Togawa, Naoyuki; Fukushima, Tatsunobu] Mitsubishi Rayon Co Ltd, Yokohama Res Labs, Kanagawa 2300053, Japan.
C3 Kanazawa University; Jichi Medical University; Mitsubishi International
   Corporation (MIC); Mitsubishi Chemical Holdings Corporation; Mitsubishi
   Rayon Co., Ltd.
RP Takamura, T (corresponding author), Kanazawa Univ, Grad Sch Med Sci, Dept Dis Control & Homeostasis, 13-1 Takara Machi, Kanazawa, Ishikawa 9208641, Japan.
EM ttakamura@m-kanazawa.jp
RI ANDO, Hitoshi/O-8199-2016; Nagata, Naoto/D-9261-2012
OI Nagata, Naoto/0000-0002-2389-2334; Togawa, Naoyuki/0000-0002-4650-4736
FU Ministry of Education, Culture, Sports, Science and Technology, Japan
FX This work was supported by in part of a Grant-in-Aid for Scientific
   Research from the Ministry of Education, Culture, Sports, Science and
   Technology, Japan.
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NR 36
TC 24
Z9 26
U1 1
U2 8
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0006-291X
EI 1090-2104
J9 BIOCHEM BIOPH RES CO
JI Biochem. Biophys. Res. Commun.
PD MAR 13
PY 2009
VL 380
IS 3
BP 684
EP 688
DI 10.1016/j.bbrc.2009.01.150
PG 5
WC Biochemistry & Molecular Biology; Biophysics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics
GA 419LZ
UT WOS:000264222400046
PM 19285022
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Garcia-Serrano, AM
   Mohr, AA
   Philippe, J
   Skoug, C
   Spégel, P
   Duarte, JMN
AF Garcia-Serrano, Alba M.
   Mohr, Adelaide A.
   Philippe, Juliette
   Skoug, Cecilia
   Spegel, Peter
   Duarte, Joao M. N.
TI Cognitive Impairment and Metabolite Profile Alterations in the
   Hippocampus and Cortex of Male and Female Mice Exposed to a Fat and
   Sugar-Rich Diet are Normalized by Diet Reversal
SO AGING AND DISEASE
LA English
DT Article
DE brain metabolism; memory; anxiety; obesity; diabetes; sucrose; high-fat
ID IN-VIVO; NEUROCHEMICAL MODIFICATIONS; N-ACETYLASPARTATE; BRAIN; OBESITY;
   NEUROGENESIS; INFLAMMATION; RATS; CNS
AB Diabetes impacts on brain metabolism, structure, and function. Alterations in brain metabolism have been observed in obesity and diabetes models induced by exposure to diets rich in saturated fat and/or sugar and have been linked to memory impairment. However, it remains to be determined whether brain dysfunction induced by obesogenic diets results from permanent brain alterations. We tested the hypothesis that an obesogenic diet (high-fat and high-sucrose diet; HFHSD) causes reversible changes in hippocampus and cortex metabolism and alterations in behavior. Mice were exposed to HFHSD for 24 weeks or for 16 weeks followed by 8 weeks of diet normalization. Development of the metabolic syndrome, changes in behavior, and brain metabolite profiles by magnetic resonance spectroscopy (MRS) were assessed longitudinally. Control mice were fed an ingredient-matched low-fat and low-sugar diet. Mice fed the HFHSD developed obesity, glucose intolerance and insulin resistance, with a more severe phenotype in male than female mice. Relative to controls, both male and female HFHSD-fed mice showed increased anxiety-like behavior, impaired memory in object recognition tasks, but preserved working spatial memory as evaluated by spontaneous alternation in a Y-maze. Alterations in the metabolite profiles were observed both in the hippocampus and cortex but were more distinct in the hippocampus. HFHSD-induced metabolic changes included altered levels of lactate, glutamate, GABA, glutathione, taurine, N-acetylaspartate, total creatine and total choline. Notably, HFHSD-induced metabolic syndrome, anxiety, memory impairment, and brain metabolic alterations recovered upon diet normalization for 8 weeks. In conclusion, cortical and hippocampal derangements induced by long-term HFHSD consumption are reversible rather than being the result of permanent tissue damage.
C1 [Garcia-Serrano, Alba M.; Philippe, Juliette; Skoug, Cecilia; Duarte, Joao M. N.] Lund Univ, Fac Med, Dept Expt Med Sci, Lund, Sweden.
   [Garcia-Serrano, Alba M.; Philippe, Juliette; Skoug, Cecilia; Duarte, Joao M. N.] Lund Univ, Wallenberg Ctr Mol Med, Lund, Sweden.
   [Mohr, Adelaide A.] Ecole Polytech Fed Lausanne EPFL, Inst Phys, Sch Basic Sci, Lausanne, Switzerland.
   [Spegel, Peter] Lund Univ, Ctr Anal & Synth, Dept Chem, Lund, Sweden.
C3 Lund University; Lund University; Swiss Federal Institutes of Technology
   Domain; Ecole Polytechnique Federale de Lausanne; Lund University
RP Duarte, JMN (corresponding author), Lund Univ, Fac Med, Dept Expt Med Sci, Lund, Sweden.
EM joao.duarte@med.lu.se
RI Spégel, Peter/G-9947-2018; Garcia-Serrano, Alba/U-5101-2019; Skoug,
   Cecilia/KCY-7907-2024; Duarte, Joao/H-4887-2012
OI Skoug, Cecilia/0000-0002-4999-1939; Duarte, Joao/0000-0001-5984-1574;
   Mohr, Adelaide/0000-0002-1085-7636
FU Swedish Research Council [2019-01130]; Crafoord Foundation;
   Diabetesfonden [Dia2019-440]; Direktor Albert Pahlssons stiftelse;
   Demensfonden; Royal Physiographic Society of Lund; Stiftelsen Lars
   Hiertas Minne; Swedish foundation for International Cooperation in
   Research and Higher Education [BR2019-8508]; Young IBRO Regions
   Connecting Award; Knut and Alice Wallenberg foundation; Medical Faculty
   at Lund University; Region Skane; Lund University Diabetes Centre -
   Swedish Research Council (Strategic Research Area EXODIAB) [2009-1039];
   Swedish Foundation for Strategic Research [IRC15-0067]; Swedish Research
   Council [2019-01130] Funding Source: Swedish Research Council
FX This work was funded by the Swedish Research Council (2019-01130) ,
   Crafoord Foundation, Diabetesfonden (Dia2019-440) , Direktor Albert
   Pahlssons stiftelse, Demensfonden, Royal Physiographic Society of Lund,
   Stiftelsen Lars Hiertas Minne, Swedish foundation for International
   Cooperation in Research and Higher Education (BR2019-8508) , and Young
   IBRO Regions Connecting Award. The Knut and Alice Wallenberg foundation,
   the Medical Faculty at Lund University and Region Skane are acknowledged
   for generous financial support to JMND. The authors acknowledge support
   from Lund University Diabetes Centre, which is funded by the Swedish
   Research Council (Strategic Research Area EXODIAB, grant 2009-1039) and
   Swedish Foundation for Strategic Research (grant IRC15-0067) .
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NR 53
TC 37
Z9 38
U1 3
U2 39
PU INT SOC AGING & DISEASE
PI FORT WORTH
PA EDITORIAL OFF, 3400 CAMP BOWIE BLVD, FORT WORTH, TX 76106 USA
SN 2152-5250
J9 AGING DIS
JI Aging Dis.
PD FEB
PY 2022
VL 13
IS 1
BP 267
EP 283
DI 10.14336/AD.2021.0720
PG 17
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA ZZ4DK
UT WOS:000773221500017
PM 35111373
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Beckie, TM
AF Beckie, Theresa M.
TI A Systematic Review of Allostatic Load, Health, and Health Disparities
SO BIOLOGICAL RESEARCH FOR NURSING
LA English
DT Review
DE allostasis; health; allostatic load
ID CUMULATIVE BIOLOGICAL RISK; CHRONIC-FATIGUE-SYNDROME; SELF-RATED HEALTH;
   SOCIOECONOMIC-STATUS; PHYSIOLOGICAL DYSREGULATION; METABOLIC SYNDROME;
   CHRONIC STRESS; SOCIAL RELATIONSHIPS; NATIONAL SAMPLE; HEART-DISEASE
AB The theoretical constructs of allostasis and allostatic load (AL) have contributed to our understanding of how constantly changing social and environmental factors impact physiological functioning and shape health and aging disparities, particularly along socioeconomic, gendered, racial, and ethnic lines. AL represents the cumulative dysregulation of biological systems with prolonged or poorly regulated allostatic responses. Nearly two decades of empirical research has focused on operationalizing the AL construct for examining the antecedents and health outcomes accompanying multisystem biological dysregulation. The purpose of this systematic review is to examine the empirical literature that quantifies the AL construct; the review also evaluates the social, environmental, and genetic antecedents of AL as well as its predictive utility for a variety of health outcomes. A total of 58 articles published between 1997 and 2012 were retrieved, analyzed, and synthesized. The results revealed considerable heterogeneity in the operationalization of AL and the measurement of AL biomarkers, making interpretations and comparisons across studies challenging. There is, however, empirical substantiation for the relationships between AL and socioeconomic status, social relationships, workplace, lifestyle, race/ethnicity, gender, stress exposure, and genetic factors. The literature also demonstrated associations between AL and physical and mental health and all-cause mortality. Targeting the antecedents of AL during key developmental periods is essential for improving public health. Priorities for future research include conducting prospective longitudinal studies, examining a broad range of antecedent allostatic challenges, and collecting reliable measures of multisystem dysregulation explicitly designed to assess AL, at multiple time points, in population-representative samples.
C1 Univ S Florida, Coll Nursing, Tampa, FL 33612 USA.
C3 State University System of Florida; University of South Florida
RP Beckie, TM (corresponding author), Univ S Florida, Coll Nursing, 12901 Bruce B Downs Blvd,MDC22, Tampa, FL 33612 USA.
EM tbeckie@health.usf.edu
RI Beckie, Theresa/R-4212-2019
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NR 98
TC 376
Z9 461
U1 3
U2 127
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1099-8004
EI 1552-4175
J9 BIOL RES NURS
JI Biol. Res. Nurs.
PD OCT
PY 2012
VL 14
IS 4
SI SI
BP 311
EP 346
DI 10.1177/1099800412455688
PG 36
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA 010XD
UT WOS:000309126900002
PM 23007870
DA 2025-06-11
ER

PT J
AU Kim, GM
   Woo, JM
   Jung, SY
   Shin, S
   Song, HJ
   Park, J
   Ahn, J
AF Kim, Gyung-Mee
   Woo, Jong-Min
   Jung, Sun-Young
   Shin, Sangjin
   Song, Hyun Jin
   Park, Jooyeon
   Ahn, Jeonghoon
TI Positive association between serious psychiatric outcomes and
   complications of diabetes mellitus in patients with depressive disorders
SO INTERNATIONAL JOURNAL OF PSYCHIATRY IN MEDICINE
LA English
DT Article
DE Depression; diabetes; comorbidity; serious outcomes
ID COMORBID DEPRESSION; RISK-FACTORS; METABOLIC SYNDROME; GLYCEMIC CONTROL;
   TYPE-2; HEALTH; ADULTS; OLDER; INDIVIDUALS; PREVALENCE
AB Objectives Depression and diabetes are closely biologically and behaviorally intertwined. We examined the impact of comorbid diabetes mellitus on the incidence of serious psychiatric outcomes among patients with depression.
   Methods We used claims data from the Korean Health Insurance Review & Assessment Service database of patients who were diagnosed with depression within one year of an index prescription for antidepressants between January 2007 and June 2008. We investigated the association between the comorbidity of diabetes mellitus and serious psychiatric outcomes of depression, such as psychiatric hospitalization, psychiatric emergency room visits, and suicide attempts.
   Results Among 200,936 patients with depression, 74,160 (36.9%) had diabetes mellitus, including 57,418 (28.6%) with complications. The incidence of serious psychiatric outcomes was 3.3% in patients with depression without diabetes and 6.7% in patients with depression and diabetes mellitus. Patients with depression and diabetes mellitus complications showed higher rates of serious outcomes than that did those without diabetes mellitus complications (odds ratio, 1.19; 95% confidence interval, 1.11-1.13). Similarly, depressed patients with micro and macrovascular diabetic complications were more likely to experience serious outcomes than those without diabetes mellitus complications (odds ratio, 2.2; 95% confidence interval, 2.07-2.34).
   Conclusions Our results showed that comorbid diabetes mellitus can increase the risk of serious outcomes of depression, such as suicide and hospitalization, and thus may alter the antidepressants prescription patterns and healthcare service use among patients with depressive disorders.
C1 [Kim, Gyung-Mee; Woo, Jong-Min; Jung, Sun-Young; Shin, Sangjin; Song, Hyun Jin; Park, Jooyeon; Ahn, Jeonghoon] Natl Evidence Based Healthcare Collaborating Agcy, Seoul, South Korea.
   [Kim, Gyung-Mee] Inje Univ, Sch Med, Haeundae Paik Hosp, Dept Psychiat, Busan, South Korea.
   [Woo, Jong-Min] Inje Univ, Seoul Paik Hosp, Dept Psychiat, Sch Med, Seoul 100032, South Korea.
   [Woo, Jong-Min] Inje Univ, Stress Res Inst, Seoul 100032, South Korea.
   [Jung, Sun-Young] Korea Inst Drug Safety & Risk Management KIDS, Seoul, South Korea.
   [Song, Hyun Jin] Sungkyunkwan Univ, Sch Pharm, Suwon, South Korea.
C3 National Evidence-based Healthcare Collaborating Agency (NECA); Inje
   University; Inje University; Inje University; Sungkyunkwan University
   (SKKU)
RP Woo, JM (corresponding author), Inje Univ, Seoul Paik Hosp, Dept Psychiat, 9 Mareunnae Ro, Seoul 100032, South Korea.
EM jongmin.woo@gmail.com
RI Woo, Jong/D-2353-2014; Ahn, Jeonghoon/CAA-1956-2022
OI Woo, Jongmin/0000-0003-1314-126X; Ahn, Jeonghoon/0000-0002-0177-0192
FU National Evidence-based Healthcare Collaborating Agency in Korea
   [NA09-008, NA10-003]
FX This study was fully funded by the National Evidence-based Healthcare
   Collaborating Agency in Korea (NA09-008, NA10-003). This study was not
   funded by any pharmaceutical company.
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NR 48
TC 10
Z9 13
U1 0
U2 12
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0091-2174
EI 1541-3527
J9 INT J PSYCHIAT MED
JI Int. J. Psychiatr. Med.
PD AUG
PY 2015
VL 50
IS 2
BP 131
EP 146
DI 10.1177/0091217415605024
PG 16
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA CU1VE
UT WOS:000363309000001
PM 26353830
DA 2025-06-11
ER

PT J
AU Vijayan, VK
AF Vijayan, Vannan Kandi
TI Morbidities associated with obstructive sleep apnea
SO EXPERT REVIEW OF RESPIRATORY MEDICINE
LA English
DT Review
DE cardiac arrhythmias; continuous positive airway pressure; endothelial
   dysfunction; hypertension; intermittent hypoxia; metabolic syndrome;
   obstructive sleep apnea; oxidative stress
ID POSITIVE AIRWAY PRESSURE; C-REACTIVE PROTEIN; SYMPATHETIC-NERVE
   ACTIVITY; IMPROVES ENDOTHELIAL FUNCTION; OXIDATIVE STRESS;
   PULMONARY-HYPERTENSION; LIPID-PEROXIDATION; BLOOD-PRESSURE;
   HEART-FAILURE; CARDIOVASCULAR-DISEASE
AB Obstructive sleep apnea (OSA)-induced biological changes include intermittent hypoxia, intermittent hypercapnia, intrathoracic pressure changes, sympathetic activation and sleep fragmentation. OSA can cause metabolic dysregulation, endothelial dysfunction, systemic inflammation, oxidative stress and hypercoagulation, and neurohumoral changes. There is evidence suggesting that OSA is independently associated with metabolic syndrome. OSA has been shown to increase the risk for systemic hypertension, pulmonary vascular disease, ischemic heart disease, cerebral vascular disease, congestive heart failure and arrhythmias. Although there are evidences accumulating that there may be a causal relationship between OSA and cardiovascular disorders, there is a need for more data from randomized controlled intervention trials to confirm this relationship. Many risk factors of OSA (age, male gender and obesity) are also known risk factors for cardiovascular disease. Severe OSA-hypopnea significantly increases the risk of fatal and nonfatal cardiovascular events in both men and women, and continuous positive airway pressure treatment reduces this risk in both. Neurocognitive consequences of OSA include daytime sleepiness, loss of alertness, memory deficit, reduced vigilance, impaired executive function, increased risk for automobile and occupational accidents, and decreased quality of life.
C1 [Vijayan, Vannan Kandi] Bhopal Mem Hosp & Res Ctr, Indian Council Med Res, Bhopal 462036, India.
   [Vijayan, Vannan Kandi] Univ Delhi, Vallabhbhai Patel Chest Inst, Delhi 110007, India.
C3 Indian Council of Medical Research (ICMR); ICMR - Bhopal Memorial
   Hospital & Research Center (BMHRC); University of Delhi
RP Vijayan, VK (corresponding author), Bhopal Mem Hosp & Res Ctr, Indian Council Med Res, Bhopal 462036, India.
EM vijayanvk@hotmail.com
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NR 114
TC 72
Z9 83
U1 0
U2 16
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1747-6348
EI 1747-6356
J9 EXPERT REV RESP MED
JI Expert Rev. Respir. Med.
PD OCT
PY 2012
VL 6
IS 5
BP 557
EP 566
DI 10.1586/ERS.12.44
PG 10
WC Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Respiratory System
GA V32NR
UT WOS:000208958400017
PM 23134249
DA 2025-06-11
ER

PT J
AU Sheikh, MY
   Choi, J
   Qadri, I
   Friedman, JE
   Sanyal, AJ
AF Sheikh, Muhammad Y.
   Choi, Jinah
   Qadri, Ishtiaq
   Friedman, Jacob E.
   Sanyal, Arun J.
TI Hepatitis C virus infection: Molecular pathways to metabolic syndrome
SO HEPATOLOGY
LA English
DT Review
ID ENDOPLASMIC-RETICULUM-STRESS; NECROSIS-FACTOR-ALPHA; MITOCHONDRIAL
   PERMEABILITY TRANSITION; ACTIVATED RECEPTOR-ALPHA; INSULIN-RESISTANCE;
   OXIDATIVE STRESS; STELLATE CELLS; LIPOPROTEIN-LIPASE; GENE-EXPRESSION;
   NADPH OXIDASE
AB Chronic infection with hepatitis C virus (HCV) can induce insulin resistance (IR) in a genotype-dependent fashion, thus contributing to steatosis, progression of fibrosis and resistance to interferon therapy. The molecular mechanisms in genotype 1 patients that lead to metabolic syndrome are still ambiguous. Based on our current understanding, HCV proteins associate with mitochondria and endoplasmic reticulum and promote oxidative stress. The latter mediates signals involving the p38 mitogen-activated protein kinase and activates nuclear factor kappa B. This transcription factor plays a key role in the expression of cytokines, tumor necrosis factor alpha (TNF-alpha), interleukin 6, interleukin 8, tumor growth factor beta, and Fas ligand. TNF-alpha inhibits the function of insulin receptor substrates and decreases the expression of the glucose transporter and lipoprotein lipase in peripheral tissues, which is responsible for the promotion of insulin resistance. Furthermore, reduced adiponectin levels, loss of adiponectin receptors, and decreased anti-inflammatory peroxisome proliferator-activated receptor alpha in the liver of HCV patients may contribute to reduced fatty acid oxidation, inflammation, and eventually lipotoxicity. This chain of events may be initiated by HCV-associated IR and provides a direction for future research in the areas of therapeutic intervention.
C1 [Sheikh, Muhammad Y.] Univ Calif San Francisco, Community Reg Med Ctr, Div Gastroenterol & Hepatol, Fresno Educ Program, Fresno, CA 93721 USA.
   [Choi, Jinah] Univ Calif Merced, Sch Nat Sci, Merced, CA USA.
   [Qadri, Ishtiaq] Natl Ctr Virol & Immunol, Rawalpindi, Pakistan.
   [Qadri, Ishtiaq] Natl Univ Sci & Technol, Rawalpindi, Pakistan.
   [Friedman, Jacob E.] Univ Colorado, Hlth Sci Ctr, Dept Pediat Biochem & Mol Genet, Denver, CO USA.
   [Sanyal, Arun J.] Virginia Commonwealth Univ Hlth Syst, Div Gastroenterol, Richmond, VA USA.
C3 University of California System; University of California San Francisco;
   University of California San Francisco at Fresno; University of
   California System; University of California Merced; National University
   of Sciences & Technology - Pakistan; University of Colorado System;
   University of Colorado Denver; University of Colorado Anschutz Medical
   Campus; Virginia Commonwealth University
RP Sheikh, MY (corresponding author), Univ Calif San Francisco, Community Reg Med Ctr, Div Gastroenterol & Hepatol, Fresno Educ Program, 2823 Fresno St,1st Floor, Fresno, CA 93721 USA.
EM msheikh@fresno.ucsf.edu
RI Qadri, Ishtiaq/I-6889-2013
OI Qadri, Ishtiaq/0000-0003-4334-0585
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NR 53
TC 200
Z9 211
U1 0
U2 14
PU JOHN WILEY & SONS INC
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 0270-9139
J9 HEPATOLOGY
JI Hepatology
PD JUN
PY 2008
VL 47
IS 6
BP 2127
EP 2133
DI 10.1002/hep.22269
PG 7
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 308LL
UT WOS:000256391500037
PM 18446789
OA Bronze
DA 2025-06-11
ER

PT J
AU Galinier, A
   Carriere, A
   Fernandez, Y
   Caspar-Bauguil, S
   Periquet, B
   Periquet, A
   Penicaud, L
   Casteilla, L
AF Galinier, Anne
   Carriere, Audrey
   Fernandez, Yvette
   Caspar-Bauguil, Sylvie
   Periquet, Brigitte
   Periquet, Alain
   Penicaud, Luc
   Casteilla, Louis
TI Site specific changes of redox metabolism in adipose tissue of obese
   Zucker rats
SO FEBS LETTERS
LA English
DT Article
DE site specificity; adipose tissue; obesity; redox state; glutathione;
   coenzyme Q
ID PERFORMANCE LIQUID-CHROMATOGRAPHY; INSULIN-RESISTANCE;
   HYDROGEN-PEROXIDE; COENZYME-Q; PLASMA; BLOOD; INFLAMMATION; ADIPOCYTES;
   EXPRESSION; STATE
AB Adipose tissues are differently involved in lipid metabolism and obesity according to their type and location. Increasing reports stress on the impact of redox metabolism on obesity and metabolic syndrome. The aim of this work is to investigate the site-specific redox metabolism in three different adipose tissues and its changes occurring in obesity. We analysed enzymatic and non-enzymatic parameters, and focused on the reduced/oxidized glutathione and coenzyme Q couples. In lean compared with obese non-diabetic Zucker rats, interscapular brown fat seems well protected against oxidative stress and epididymal adipose tissue shows a more reduced glutathione redox state, associated with a higher susceptibility to lipophilic oxidative stress than inguinal adipose tissue. Epididymal adipose tissue redox metabolism significantly differs from inguinal one by its limited redox metabolism adaptation. Our results demonstrate site-specific managements of reactive oxygen species metabolism in obese Zucker rats. These results are not consistent with the classic deciphering of inflammatory situation and produce a new conception of the redox parameters implication in the development of the metabolic syndrome. (c) 2006 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
C1 CHU Rangueil, Biochim Lab, F-31059 Toulouse 09, France.
   CHU Rangueil, CNRS, IFR 31, UMR 5018,UPS, F-31059 Toulouse 9, France.
C3 CHU de Toulouse; Universite de Toulouse; Universite Toulouse III - Paul
   Sabatier; Universite de Toulouse; Universite Toulouse III - Paul
   Sabatier; CHU de Toulouse; Centre National de la Recherche Scientifique
   (CNRS)
RP Galinier, A (corresponding author), CHU Rangueil, Biochim Lab, 1 Ave Poulhes, F-31059 Toulouse 09, France.
EM galinier.a@chu-toulouse.fr
OI Casteilla, Louis/0000-0001-9647-3248; Galinier,
   Anne/0000-0003-2454-5681; Caspar-Bauguil, Sylvie/0000-0003-2682-0704;
   Carriere, Audrey/0000-0002-4277-7905
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NR 35
TC 31
Z9 34
U1 0
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0014-5793
EI 1873-3468
J9 FEBS LETT
JI FEBS Lett.
PD NOV 27
PY 2006
VL 580
IS 27
BP 6391
EP 6398
DI 10.1016/j.febslet.2006.10.052
PG 8
WC Biochemistry & Molecular Biology; Biophysics; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Cell Biology
GA 114KS
UT WOS:000242665700016
PM 17098232
OA Bronze
DA 2025-06-11
ER

PT J
AU Park, S
   Choi, NK
AF Park, Sangshin
   Choi, Nam-Kyong
TI Breastfeeding reduces risk of depression later in life in the
   postmenopausal period: A Korean population-based study
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Breastfeeding; Lactation; Depression; The Patient Health Questionnaire 9
ID POSTPARTUM DEPRESSION; METABOLIC SYNDROME; VALIDITY
AB Objective: The relationship between breastfeeding and maternal depression in later life has not yet been investigated. We examined whether the number of breastfed infants or the period of breastfeeding influenced maternal depression in postmenopausal women.
   Methods: We analyzed 1,372 parous postmenopausal women aged >= 50 years who had participated in the Korea National Health and Nutrition Examination Survey 2014. Depression was diagnosed using the Patient Health Questionnaire 9, with scores of 10 or higher indicating depression. Logistic regression analyses were performed to examine the relationships between breastfeeding and postmenopausal depression.
   Results: Women with a moderate (2-3) or high (4-12) number of breastfed infants had 65% [odds ratio (OR) = 0.35, 95% confidence interval (CI) = 0.19-0.65] and 77% (OR = 0.23, 95% CI = 0.10-0.55) decreased risks of depression, respectively, compared to those with low numbers of infants (0-1). Women who breastfed their infants for long periods (47-432 months) had 67% (OR = 0.33, 95% CI = 0.16-0.68) decreased risk of depression, compared to those who breastfed for short periods (0-23 months). The risk of depression decreased by 29% (OR = 0.71, 95% CI = 0.58-0.87) for each additional infant breastfed and by 9% (OR = 0.91, 95% CI = 0.82- < 1.00) for each additional year of breastfeeding. The population-attributable fraction of depression associated with < 2 infants breastfed was 17.3% (95% CI = 14.2-20.3%), while the fraction associated with a period of breastfeeding < 24 months was not significant.
   Conclusions: Women with more breastfed infants or longer period of breastfeeding are at decreased risk of depression in the postmenopausal period.
C1 [Park, Sangshin] Brown Univ, Rhode Isl Hosp, Ctr Int Hlth Res, Warren Alpert Med Sch, Providence, RI 02903 USA.
   [Park, Sangshin] Brown Univ, Dept Pediat, Warren Alpert Med Sch, Providence, RI 02912 USA.
   [Park, Sangshin] Univ Seoul, Grad Sch Urban Publ Hlth, Seoul, South Korea.
   [Choi, Nam-Kyong] Ewha Womans Univ, Dept Hlth Convergence, 52 Ewhayeodae Gil, Seoul 03760, South Korea.
C3 Lifespan Health Rhode Island; Rhode Island Hospital; Brown University;
   Brown University; University of Seoul; Ewha Womans University
RP Choi, NK (corresponding author), Ewha Womans Univ, Dept Hlth Convergence, 52 Ewhayeodae Gil, Seoul 03760, South Korea.
EM nchoi@ewha.ac.kr
RI Park, Sangshin/K-6889-2014
OI Park, Sangshin/0000-0003-2407-0962
CR [Anonymous], 2009, INF YOUNG CHILD FEED
   [Anonymous], 2004, PROTECTION PROMOTION
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NR 34
TC 4
Z9 4
U1 0
U2 12
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD APR 1
PY 2019
VL 248
BP 13
EP 17
DI 10.1016/j.jad.2018.12.081
PG 5
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA HL4MQ
UT WOS:000458696300002
PM 30708102
DA 2025-06-11
ER

PT J
AU Lee, YL
   Lin, KL
   Wu, BN
   Chuang, SM
   Wu, WJ
   Lee, YC
   Ho, WT
   Juan, YS
AF Lee, Yi-Lun
   Lin, Kun-Ling
   Wu, Bin-Nan
   Chuang, Shu-Mien
   Wu, Wen-Jeng
   Lee, Yung-Chin
   Ho, Wan-Ting
   Juan, Yung-Shun
TI Epigallocatechin-3-gallate alleviates bladder overactivity in a rat
   model with metabolic syndrome and ovarian hormone deficiency through
   mitochondria apoptosis pathways
SO SCIENTIFIC REPORTS
LA English
DT Article
ID ENDOPLASMIC-RETICULUM STRESS; GREEN TEA CATECHINS; OXIDATIVE STRESS;
   CELL-DEATH; MENOPAUSE; NEUROPROTECTION; HYPERGLYCEMIA; POLYPHENOLS;
   MODULATION; ACTIVATION
AB Metabolic syndrome (MetS) and ovarian hormone deficiency could affect bladder storage dysfunction. Epigallocatechin-3-gallate (EGCG), a polyphenolic compound in green tea, has been shown to protect against ovarian hormone deficiency induced overactive bladder (OAB). The present study investigated oxidative stress induced by MetS and bilateral ovariectomy (OVX), and elucidated the mechanism underlying the protective effect of EGCG (10 umol/kg/day) on bladder overactivity. Rats were fed with high fat high sugar (HFHS) diet to induce MetS and received ovariectomy surgery to deprive ovarian hormone. By dieting with HFHS for 6 months, rats developed MetS and OAB. MetS + OVX deteriorated bladder storage dysfunction more profound than MetS alone. MetS and MetS + OVX rats showed over-expression of inflammatory and fibrosis markers (1.7 similar to 3.8-fold of control). EGCG pretreatment alleviated storage dysfunction, and protected the bladders from MetS and OVX - induced interstitial fibrosis changes. Moreover, OVX exacerbated MetS related bladder apoptosis (2.3 similar to 4.5-fold of control; 1.8 similar to 2.6-fold of Mets group), enhances oxidative stress markers (3.6 similar to 4.3-fold of control; 1.8 similar to 2.2-fold of Mets group) and mitochondrial enzyme complexes subunits (1.8 similar to 3.7-fold of control; 1.5 similar to 3.4-fold of Mets group). EGCG pretreatment alleviated bladder apoptosis, attenuated oxidative stress, and reduced the mitochondrial and endoplasmic reticulum apoptotic signals. In conclusions, HFHS feeding and ovarian hormone deficiency enhances the generation of oxidative stress mediated through mitochondrial pathway. EGCG reduced the generation of oxidative stress and lessened bladder overactivity.
C1 [Lee, Yi-Lun; Wu, Bin-Nan; Wu, Wen-Jeng; Juan, Yung-Shun] Kaohsiung Med Univ, Coll Med, Grad Inst Med, Kaohsiung, Taiwan.
   [Lee, Yi-Lun] Minist Hlth & Welf, Sinying Hosp, Dept Urol, Tainan, Taiwan.
   [Lin, Kun-Ling] Kaohsiung Med Univ, Grad Inst Clin Med, Coll Med, Kaohsiung, Taiwan.
   [Lin, Kun-Ling] Kaohsiung Med Univ Hosp, Dept Obstet & Gynecol, Kaohsiung, Taiwan.
   [Wu, Bin-Nan] Kaohsiung Med Univ, Coll Med, Dept Pharmacol, Kaohsiung, Taiwan.
   [Chuang, Shu-Mien] Kaohsiung Med Univ, Dept Med Res, Canc Ctr, Translat Res Ctr, Kaohsiung, Taiwan.
   [Wu, Wen-Jeng; Lee, Yung-Chin; Ho, Wan-Ting; Juan, Yung-Shun] Kaohsiung Med Univ, Coll Med, Dept Urol, Kaohsiung, Taiwan.
   [Wu, Wen-Jeng; Lee, Yung-Chin; Ho, Wan-Ting; Juan, Yung-Shun] Kaohsiung Med Univ Hosp, Dept Urol, Kaohsiung, Taiwan.
   [Wu, Wen-Jeng; Juan, Yung-Shun] Kaohsiung Municipal Tatung Hosp, Dept Urol, Kaohsiung, Taiwan.
   [Lee, Yung-Chin] Kaohsiung Municipal Hsiaokang Hosp, Dept Urol, Kaohsiung, Taiwan.
C3 Kaohsiung Medical University; Kaohsiung Medical University; Kaohsiung
   Medical University; Kaohsiung Medical University Hospital; Kaohsiung
   Medical University; Kaohsiung Medical University; Kaohsiung Medical
   University; Kaohsiung Medical University; Kaohsiung Medical University
   Hospital; Kaohsiung Medical University; Kaohsiung Municipal Ta-Tung
   Hospital; Kaohsiung Medical University; Kaohsiung Municipal Siao-Gang
   Hospital
RP Juan, YS (corresponding author), Kaohsiung Med Univ, Coll Med, Grad Inst Med, Kaohsiung, Taiwan.; Juan, YS (corresponding author), Kaohsiung Med Univ, Coll Med, Dept Urol, Kaohsiung, Taiwan.; Juan, YS (corresponding author), Kaohsiung Med Univ Hosp, Dept Urol, Kaohsiung, Taiwan.; Juan, YS (corresponding author), Kaohsiung Municipal Tatung Hosp, Dept Urol, Kaohsiung, Taiwan.
EM juanuro@gmail.com
RI Lee, Yung-Chin/A-2027-2010; Wu, Wen-Jeng/C-7267-2009; Wu,
   Bin-Nan/ITV-0893-2023
OI wu, wen jeng/0000-0002-9691-7416
FU Ministry of Science and Technology [NSC-105-2314-B-037-043-MY3];
   Department of Medical Research, Kaohsiung Medical University Hospital
   grant [KMUH-104-4R45, KMUH-105-5R44, KMUH -106-6R60]; Kaohsiung
   Kaohsiung Municipal Hsiao-Kang Hospital grant [Kmhk-103-021,
   Kmhk-104-021]; Ministry of Health and Welfare [MOHW103-TD-B-111-05]
FX We are grateful to Professor Chang-Hwei Chen of the University at
   Albany, State University of New York for his valuable comments on this
   manuscript. Grant numbers and sources of support: This research is
   supported by the grant from the Ministry of Science and Technology
   (NSC-105-2314-B-037-043-MY3), in part by the Department of Medical
   Research, Kaohsiung Medical University Hospital grant (KMUH-104-4R45,
   KMUH-105-5R44, KMUH -106-6R60) in part by Kaohsiung Kaohsiung Municipal
   Hsiao-Kang Hospital grant (Kmhk-103-021, Kmhk-104-021) and Ministry of
   Health and Welfare (MOHW103-TD-B-111-05).
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NR 46
TC 19
Z9 19
U1 0
U2 6
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD MAR 29
PY 2018
VL 8
AR 5358
DI 10.1038/s41598-018-23800-w
PG 15
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA GA8VI
UT WOS:000428618900001
PM 29599473
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Yan, YX
   Xiao, HB
   Wang, SS
   Zhao, J
   He, Y
   Wang, W
   Dong, J
AF Yan, Yu-Xiang
   Xiao, Huan-Bo
   Wang, Si-Si
   Zhao, Jing
   He, Yan
   Wang, Wei
   Dong, Jing
TI Investigation of the Relationship Between Chronic Stress and Insulin
   Resistance in a Chinese Population
SO JOURNAL OF EPIDEMIOLOGY
LA English
DT Article
DE stress; insulin resistance; cortisol; HOMA-IR
ID SUBOPTIMAL HEALTH-STATUS; METABOLIC SYNDROME; GLUCOSE; DISEASE; RISK;
   ASSOCIATION; MECHANISMS; MEDIATORS; CORTISOL; WORK
AB Background: Chronic stress may facilitate the development of metabolic diseases. Insulin resistance is present long before the clinical manifestations of individual metabolic abnormalities. To explore whether chronic stress is an independent risk factor of insulin resistance, we investigated the relationship between the stress system, selected parameters of energy homeostasis, and insulin resistance in a Chinese population.
   Methods: We recruited 766 workers employed at four companies in Beijing. The degree of insulin resistance was determined using the homeostasis model assessment of insulin resistance (HOMA-IR). The highest quartile of HOMA-IR among all study subjects was further defined as insulin resistance in our study. The short standard version of the Copenhagen Psychosocial Questionnaire (COPSOQ) was used to assess job-related psychosocial stress. Pearson's correlation coefficients were calculated between cortisol level and HOMA-IR and components of metabolic syndrome, with stratification by gender. The relationship between cortisol and HOMA-IR independent of obesity was analyzed using a linear mixed model with company as a cluster unit.
   Results: The values of the two scales of COPSOQ, including "demands at work" and "insecurity at work", were significantly associated with insulin resistance and cortisol concentration (P < 0.05). Cortisol was significantly positively correlated with glucose, HOMA-IR, and waist circumference in males and females (P < 0.05). After adjusting for potential confounders, cortisol was an independent positive predictor for HOMA-IR (P < 0.05).
   Conclusions: These findings showed that chronic stress was associated with insulin resistance and may contribute to the development of insulin resistance.
C1 [Yan, Yu-Xiang; Wang, Si-Si; He, Yan; Wang, Wei] Capital Med Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing, Peoples R China.
   [Yan, Yu-Xiang; He, Yan; Wang, Wei] Municipal Key Lab Clin Epidemiol, Beijing, Peoples R China.
   [Xiao, Huan-Bo] Capital Med Univ, Yanjing Med Coll, Dept Prevent Med, Beijing, Peoples R China.
   [Zhao, Jing; Dong, Jing] Capital Med Univ, Xuanwu Hosp, Hlth Med Examinat Ctr, 45 Changchun St, Beijing 100053, Peoples R China.
   [Wang, Wei] Edith Cowan Univ, Sch Med Sci, Perth, WA, Australia.
C3 Capital Medical University; Capital Medical University; Capital Medical
   University; Edith Cowan University
RP Dong, J (corresponding author), Capital Med Univ, Xuanwu Hosp, Hlth Med Examinat Ctr, 45 Changchun St, Beijing 100053, Peoples R China.
EM dongjingepi@163.com
RI Wang, Anxin/AAD-4073-2021; Dong, Jing/KDM-6171-2024
FU National Natural Science Foundation [81573214]; Scientific Research
   Common Program of Beijing Municipal Commission of Education
   [KM201510025006]; Importation and Development of High-Caliber Talents
   Project of Beijing Municipal Institutions [CITTCD201304181]; National
   Science and Technology Support Program [2012BAI37B03]
FX This study was supported by the National Natural Science Foundation
   (81573214), the Scientific Research Common Program of Beijing Municipal
   Commission of Education (KM201510025006), the Importation and
   Development of High-Caliber Talents Project of Beijing Municipal
   Institutions (CIT&TCD201304181), and the National Science and Technology
   Support Program (2012BAI37B03).
CR Barthel A, 2003, MED KLIN, V98, P283, DOI 10.1007/s00063-003-1258-9
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NR 21
TC 42
Z9 48
U1 0
U2 8
PU JAPAN EPIDEMIOLOGICAL ASSOC
PI TOKYO
PA C/O UNIBO PRESS, HONGO MT BLDG 4F, 7-2-2 HONGO, BUNKYO-KU, TOKYO,
   113-0033, JAPAN
SN 0917-5040
EI 1349-9092
J9 J EPIDEMIOL
JI J. Epidemiol.
PD JUL
PY 2016
VL 26
IS 7
BP 355
EP 360
DI 10.2188/jea.JE20150183
PG 6
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA DR2PC
UT WOS:000379745400004
PM 26830350
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Copeland, WE
   Wolke, D
   Lereya, ST
   Shanahan, L
   Worthman, C
   Costello, EJ
AF Copeland, William E.
   Wolke, Dieter
   Lereya, Suzet Tanya
   Shanahan, Lilly
   Worthman, Carol
   Costello, E. Jane
TI Childhood bullying involvement predicts low-grade systemic inflammation
   into adulthood
SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF
   AMERICA
LA English
DT Article
DE stress; social functioning; longitudinal; risk factor; epidemiology
ID C-REACTIVE PROTEIN; PHYSIOLOGICAL STRESS-RESPONSE;
   CORONARY-HEART-DISEASE; SOCIOECONOMIC-STATUS; CARDIOVASCULAR-DISEASE;
   PSYCHIATRIC-DISORDERS; PEER VICTIMIZATION; METABOLIC SYNDROME;
   RISK-FACTORS; BLOOD SPOTS
AB Bullying is a common childhood experience that involves repeated mistreatment to improve or maintain one's status. Victims display long-term social, psychological, and health consequences, whereas bullies display minimal ill effects. The aim of this study is to test how this adverse social experience is biologically embedded to affect short- r long-term levels of C-reactive protein (CRP), a marker of low-grade systemic inflammation. The prospective population-based Great Smoky Mountains Study (n = 1,420), with up to nine waves of data per subject, was used, covering childhood/adolescence (ages 9-16) and young adulthood (ages 19 and 21). Structured interviews were used to assess bullying involvement and relevant covariates at all childhood/adolescent observations. Blood spots were collected at each observation and assayed for CRP levels. During childhood and adolescence, the number of waves at which the child was bullied predicted increasing levels of CRP. Although CRP levels rose for all participants from childhood into adulthood, being bullied predicted greater increases in CRP levels, whereas bullying others predicted lower increases in CRP compared with those uninvolved in bullying. This pattern was robust, controlling for body mass index, substance use, physical and mental health status, and exposures to other childhood psychosocial adversities. A child's role in bullying may serve as either a risk or a protective factor for adult low-grade inflammation, independent of other factors. Inflammation is a physiological response that mediates the effects of both social adversity and dominance on decreases in health.
C1 [Copeland, William E.; Costello, E. Jane] Duke Univ, Med Ctr, Dept Psychiat & Behav Sci, Durham, NC 27713 USA.
   [Wolke, Dieter; Lereya, Suzet Tanya] Univ Warwick, Dept Psychol, Coventry CV4 7AL, W Midlands, England.
   [Wolke, Dieter; Lereya, Suzet Tanya] Univ Warwick, Div Mental Hlth & Wellbeing, Coventry CV4 7AL, W Midlands, England.
   [Shanahan, Lilly] Univ N Carolina, Dept Psychol, Chapel Hill, NC 27599 USA.
   [Worthman, Carol] Emory Univ, Dept Anthropol, Atlanta, GA 30322 USA.
C3 Duke University; University of Warwick; University of Warwick;
   University of North Carolina; University of North Carolina Chapel Hill;
   Emory University
RP Copeland, WE (corresponding author), Duke Univ, Med Ctr, Dept Psychiat & Behav Sci, Durham, NC 27713 USA.
EM william.copeland@duke.edu
RI Shanahan, Lilly/HNJ-6173-2023; Wolke, Dieter/C-5372-2008; Copeland,
   William E/N-5413-2014
OI Worthman, Carol M/0000-0002-5397-2298; Wolke,
   Dieter/0000-0003-0304-268X; Lereya, Suzet Tanya/0000-0001-9100-459X;
   Copeland, William E/0000-0002-1348-7781; Shanahan,
   Lilly/0000-0002-4534-6924
FU National Institute of Mental Health [MH63970, MH63671, MH48085,
   MH080230]; National Institute on Drug Abuse [DA/MH11301, DA023026];
   National Alliance for Research on Schizophrenia and Depression; William
   T. Grant Foundation; Economic and Social Research Council in the United
   Kingdom [ES/K003593/1]; ESRC [ES/K003593/1] Funding Source: UKRI
FX This work was supported by the National Institute of Mental Health
   (MH63970, MH63671, MH48085, and MH080230), the National Institute on
   Drug Abuse (DA/MH11301 and DA023026), the National Alliance for Research
   on Schizophrenia and Depression (Early Career Award to W. E. C.), the
   William T. Grant Foundation, and the Economic and Social Research
   Council in the United Kingdom (ES/K003593/1).
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NR 60
TC 199
Z9 224
U1 1
U2 81
PU NATL ACAD SCIENCES
PI WASHINGTON
PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA
SN 0027-8424
J9 P NATL ACAD SCI USA
JI Proc. Natl. Acad. Sci. U. S. A.
PD MAY 27
PY 2014
VL 111
IS 21
BP 7570
EP 7575
DI 10.1073/pnas.1323641111
PG 6
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Science & Technology - Other Topics
GA AH8TO
UT WOS:000336411300028
PM 24821813
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Tepebasi, MY
   Savran, M
   Cosan, S
   Tastan, SA
   Aydin, B
AF Tepebasi, Muhammet Yusuf
   Savran, Mehtap
   Cosan, Samet
   Tastan, Serife Agirca
   Aydin, Buenyamin
TI The protective role of selenium against high-fructose corn syrup-induced
   kidney damage: a histopathological and molecular analysis
SO NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
LA English
DT Article
DE Apoptosis; Endoplasmic reticulum stress; High-fructose diet; Kidney;
   Rats; Selenium
ID ENDOPLASMIC-RETICULUM STRESS; INDUCED OXIDATIVE STRESS; INJURY;
   MECHANISMS; APOPTOSIS; EXTRACT; DISEASE
AB With the growth of the food industry, fructose, the intake of which increases with food, causes obesity and metabolic syndrome. Kidney damage may develop from metabolic syndrome. Selenium (Se) participates in the structure of antioxidant enzymes and has a medicinal effect. In this work, the protective impact of Se on kidney damage produced by high-fructose corn syrup (HFCS) via endoplasmic reticulum (ER) stress was examined. The study comprised four groups, each consisting of ten experimental animals: control, HFCS (20%-HFCS), HFCS (20%-HFCS), + Se (0.3 mg/kg/day/po), and Se (0.3 mg/kg/day/po) alone. The duration of the experiment was 6 weeks. Kidney tissues were stained with hematoxylin and eosin for histological examination. Immunohistochemical analysis was conducted to assess TNF-alpha and caspase-3 levels. The spectrophotometric evaluation was performed to measure TOS (total oxidant status), TAS (total antioxidant status), and OSI (oxidative stress index) levels. The PERK, ATF4, CHOP, BCL-2, and caspase-9 gene expression levels were assessed by the RT-qPCR method. After Se treatment, histopathological abnormalities and TNF-alpha and caspase-3 levels in the HFCS+Se group decreased (p < 0.001). While TOS and OSI levels increased dramatically in the HFCS group, TAS values decreased significantly but improved after Se application (p < 0.001). The expression levels of the genes PERK, ATF4, CHOP, and caspase-9 were significantly lower in the HFCS group when compared to the HFCS+Se group (p < 0.05). Our findings suggest that Se may protect against ER stress, oxidative stress, apoptosis, and kidney damage caused by high-dose fructose consumption.
C1 [Tepebasi, Muhammet Yusuf] Univ Suleyman Demirel, Dept Med Genet, TR-32300 Isparta, Turkiye.
   [Savran, Mehtap; Cosan, Samet] Suleyman Demirel Univ, Dept Med Pharmacol, Isparta, Turkiye.
   [Tastan, Serife Agirca] Univ Mehmet Akif Ersoy, Dept Patol, Burdur, Turkiye.
   [Aydin, Buenyamin] Kutahya Hlth Sci Univ, Dept Internal Med, Kutahya, Turkiye.
C3 Suleyman Demirel University; Suleyman Demirel University; Mehmet Akif
   Ersoy University; Kutahya Health Sciences University
RP Tepebasi, MY (corresponding author), Univ Suleyman Demirel, Dept Med Genet, TR-32300 Isparta, Turkiye.
EM muhammettepebasi@sdu.edu.tr
RI Tepebasi, Muhammet Yusuf/IZE-6149-2023
OI Tepebasi, Muhammet Yusuf/0000-0002-1087-4874
FU Sleyman Demirel niversitesi
FX No Statement Available
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NR 42
TC 1
Z9 1
U1 7
U2 10
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0028-1298
EI 1432-1912
J9 N-S ARCH PHARMACOL
JI Naunyn-Schmiedebergs Arch. Pharmacol.
PD OCT
PY 2024
VL 397
IS 10
BP 7829
EP 7837
DI 10.1007/s00210-024-03149-w
EA MAY 2024
PG 9
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA I2O0O
UT WOS:001220849400001
PM 38734838
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Wojciak, PA
   Pawluszewicz, P
   Diemieszczyk, I
   Komorowska-Wojtunik, E
   Czerniawski, M
   Kretowski, A
   Blachnio-Zabielska, A
   Dadan, J
   Ladny, J
   Hady, HR
AF Wojciak, Pawel A.
   Pawluszewicz, Patrycja
   Diemieszczyk, Inna
   Komorowska-Wojtunik, Ewa
   Czerniawski, Mikolaj
   Kretowski, Adam
   Blachnio-Zabielska, Agnieszka
   Dadan, Jacek
   Ladny, Jerzy
   Hady, Hady Razak
TI Laparoscopic sleeve gastrectomy: a study of efficiency in treatment of
   metabolic syndrome components, comorbidities and influence on certain
   biochemical markers
SO VIDEOSURGERY AND OTHER MINIINVASIVE TECHNIQUES
LA English
DT Article
DE metabolic syndrome; obesity; morbid obesity; bariatric surgery;
   laparoscopic sleeve gastrectomy
ID Y GASTRIC BYPASS; BARIATRIC SURGERY; OBESE-PATIENTS; LIPID PROFILE;
   SINGLE-CENTER; MORTALITY; IMPACT; EPIDEMIOLOGY; PARAMETERS; OUTCOMES
AB Introduction: The worldwide outbreak of morbid obesity forced contemporary medicine to adopt a multidisciplinary approach, which led to the description of metabolic syndrome (MS): a disease with self-aggravating components and one of the most important causes of morbidity and mortality. The need for therapeutic methods provoked development of metabolic surgery, which nowadays give possibilities for safe and effective treatment of all MS aspects simultaneously and improves many obesity-related comorbidities.
   Aim: To assess the laparoscopic sleeve gastrectomy (LSG) procedure's efficiency in resolving MS components, treating comorbidities and to analyze the influence on certain biochemical markers in 1-year follow-up.
   Material and methods: The retrospective cohort study of 211 patients after an LSG operation relied on statistical analysis of clinical data collected prospectively in follow-up visits. All applicable guidelines and bioethical recommendations were respected in this study.
   Results: Assessment of bariatric efficiency proved the LSG operation to be effective in inducing significant weight loss and treating obesity. Analysis on the influence on MS components, such as non-insulin dependent diabetes (NIDDM), arterial hypertension (AH) and dyslipidemia, showed substantial improvement in all observed cases of these diseases. In the present study, follow-up also proved a partial remission inducing effect of this bariatric operation in many comorbidities, especially in chronic obstructive pulmonary disease, obstructive sleep apnea, peptic ulcer disease and depression. A desirable reduction in creatinine, C-reactive protein, uric acid, alanine aminotransferase, asparagine aminotransferase, g-glutamyltransferase serum levels has also been observed during the follow-up.
   Conclusions: The LSG is an effective method of treatment in all areas of metabolic syndrome, provides a significant positive clinical outcome in obesity-related comorbidities and induces desirable changes in inflammatory, kidney and liver related biomarkers.
C1 [Wojciak, Pawel A.; Pawluszewicz, Patrycja; Diemieszczyk, Inna; Czerniawski, Mikolaj; Dadan, Jacek; Ladny, Jerzy; Hady, Hady Razak] Univ Clin Hosp Bialystok, Dept Gen & Endocrine Surg 1, 22-10 Bialostoczek St, PL-15869 Bialystok, Poland.
   [Komorowska-Wojtunik, Ewa] Minist Interior Hosp Bialystok, Intens Care Unit, Bialystok, Poland.
   [Kretowski, Adam] Univ Clin Hosp Bialystok, Dept Endocrinol Diabetol & Internal Dis, Bialystok, Poland.
   [Blachnio-Zabielska, Agnieszka] Med Univ Bialystok, Dept Hyg Epidemiol & Metab Disorders, Bialystok, Poland.
C3 Medical University of Bialystok
RP Wojciak, PA (corresponding author), Univ Clin Hosp Bialystok, Dept Gen & Endocrine Surg 1, 22-10 Bialostoczek St, PL-15869 Bialystok, Poland.
EM maphius@o2.pl
RI Blachnio-Zabielsk, Agnieszka/A-4879-2018; Ladny, Jerzy/S-4769-2018;
   Hady, Hady/T-7613-2018; Diemieszczyk, Inna/X-6657-2018; Kretowski,
   Adam/U-6299-2018
OI Kretowski, Adam/0000-0002-4522-4978; Dadan, Jacek/0000-0002-0691-9785
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NR 50
TC 18
Z9 19
U1 0
U2 4
PU TERMEDIA PUBLISHING HOUSE LTD
PI POZNAN
PA KLEEBERGA ST 2, POZNAN, 61-615, POLAND
SN 1895-4588
EI 2299-0054
J9 VIDEOSURGERY MINIINV
JI Videosurgery Miniinvasive Tec.
PY 2020
VL 15
IS 1
BP 136
EP 147
DI 10.5114/wiitm.2019.84718
PG 12
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA KI1RL
UT WOS:000511125300019
PM 32117497
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Frisard, M
   Ravussin, E
AF Frisard, M
   Ravussin, E
TI Energy metabolism and oxidative stress - Impact on the metabolic
   syndrome and the aging process
SO ENDOCRINE
LA English
DT Article
DE oxidative stress; aging; obesity; type 2 diabetes; energy expenditure
ID RESPIRATORY-CHAIN FUNCTION; HUMAN SKELETAL-MUSCLE; CALORIC RESTRICTION;
   MITOCHONDRIAL-DNA; HYDROGEN-PEROXIDE; DIETARY RESTRICTION;
   LIPID-PEROXIDATION; PROTEIN OXIDATION; RISK FACTOR; COMPLEX-I
AB Aging can be defined as a progressive decline in the ability of the organism to resist stress, damage, and disease. Although there are currently over 300 theories to explain the aging phenomenon, it is still not well understood why organisms age and why the aging process can vary so much in speed and quality from individual to individual. The oxidative stress hypothesis is one of the prevailing theories of aging. This theory states that free radicals produced during cellular respiration damage lipids, proteins, and DNA thereby accelerating the aging process and increasing disease risk. Under normal conditions, the electron transport chain is the primary producer of the superoxide anion, which is precursor to other highly reactive species such as hydrogen peroxide and the hydroxyl radical. Oxidative stress accumulates when prooxidants overwhelm the antioxidant defense mechanisms. This is dependent on a number of factors including free radical production, susceptibility of tissue to stress, and strength of the defense and repair system. Oxidative stress has been implicated in a number of chronic disease states usually grouped under the umbrella of the metabolic syndrome and is thought to contribute to the aging process. It has been hypothesized that the production of free radicals is dependent on resting metabolic rate and this may have an impact on the aging process. However, other factors, such as mitochondrial function, may be important in the production of free radicals and the subsequent effect on aging and disease states.
C1 Louisiana State Univ, Pennington Biomed Res Ctr, Baton Rouge, LA 70808 USA.
C3 Louisiana State University System; Louisiana State University;
   Pennington Biomedical Research Center
RP Louisiana State Univ, Pennington Biomed Res Ctr, 6400 Perkins Rd, Baton Rouge, LA 70808 USA.
EM ravusse@pbrc.edu
RI Ravussin, Eric/N-1985-2017
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NR 82
TC 142
Z9 168
U1 3
U2 17
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1355-008X
EI 1559-0100
J9 ENDOCRINE
JI Endocrine
PD FEB
PY 2006
VL 29
IS 1
BP 27
EP 32
DI 10.1385/ENDO:29:1:27
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 032JZ
UT WOS:000236772000005
PM 16622290
DA 2025-06-11
ER

PT J
AU Mansuroglu, S
   Kutlu, FY
AF Mansuroglu, Sercan
   Kutlu, F. Yasemin
TI The Transtheoretical Model based psychoeducation's effect on healthy
   lifestyle behaviours in schizophrenia: A randomized controlled trial
SO ARCHIVES OF PSYCHIATRIC NURSING
LA English
DT Article
DE Schizophrenia; Transtheoretical Model; Healthy lifestyle; Behavioural
   change; Mental health; Psychiatric nurse
ID QUALITY-OF-LIFE; SEVERE MENTAL-ILLNESS; PHYSICAL HEALTH; METABOLIC
   SYNDROME; BIPOLAR DISORDER; RISK-FACTORS; IMPROVEMENT PROFILE;
   CARDIOVASCULAR RISK; SMOKING-CESSATION; EXERCISE BEHAVIOR
AB Objective: The study was conducted with the pretest-posttest randomized controlled trial design to detect the psychoeducation's effect, based on the Transtheoretical Model, on the healthy lifestyle behaviours of individuals with schizophrenia.Methods: The data were collected from 82 participants, as 41 intervention and 41 control. The data were collected via personal information form, behavioural change stage diagnosis form and healthy lifestyle scale II. 6-week psychoeducation, consisting of 6 modules, based on the Transtheoretical Model, was applied to the interven-tion group. No interventions were applied to the control group. Pretests and posttests were applied to both groups.Results: When the healthy lifestyle scale II of intervention and control groups and final test results arranged according to ANCOVA analysis are compared, average final test results were meaningfully positive for the intervention group with taking control of the pretest and other covariants. When the pretest-posttest results in terms of behavioural change of the intervention group are evaluated; a meaningful difference among nutrition, physical exercises, spiritual self-improvement and stress management, which all are the stages of behavioural change, was detected.Conclusion: It was determined that psychoeducation on a healthy lifestyle, based on the Transtheoretical Model in an individual with schizophrenia affected physical exercises, spiritual self-improvement and interpersonal re-lationships sub-dimension in medium level, and had a drastic influence on health responsibility, nutrition, stress management sub-dimensions and all healthy lifestyle behaviours. Progress in behavioural change stages was detected.Clinical trials ID: NCT05259748.
C1 [Mansuroglu, Sercan] Istanbul Univ Cerrahpasa, Inst Grad Studies, Dept Mental Hlth & Psychiat Nursing, Istanbul, Turkey.
   [Kutlu, F. Yasemin] Istanbul Univ Cerrahpasa, Florence Nightingale Fac Nursing, Dept Mental Hlth & Psychiat Nursing, Istanbul, Turkey.
C3 Istanbul University - Cerrahpasa; Istanbul University - Cerrahpasa
RP Mansuroglu, S (corresponding author), Istanbul Univ Cerrahpasa, Inst Grad Studies, Dept Mental Hlth & Psychiat Nursing, Istanbul, Turkey.
EM sercanmansuroglu@gmail.com; kutluy@iuc.edu.tr
RI Mansuroğlu, Sercan/AGD-4682-2022; Kutlu, Fatma Yasemin/Q-6107-2017
OI Kutlu, Fatma Yasemin/0000-0003-0596-4258; Mansuroglu,
   Sercan/0000-0001-7562-0843
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NR 106
TC 5
Z9 5
U1 3
U2 37
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0883-9417
EI 1532-8228
J9 ARCH PSYCHIAT NURS
JI Arch. Psychiatr. Nurs.
PD DEC
PY 2022
VL 41
BP 51
EP 61
DI 10.1016/j.apnu.2022.07.018
EA JUL 2022
PG 11
WC Nursing; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Psychiatry
GA 3P0ZT
UT WOS:000837269700007
PM 36428075
DA 2025-06-11
ER

PT J
AU Mitchell, JC
   Paulson, J
   Cannarozzi, M
   Neer, SM
   Cassisi, JE
AF Mitchell, Jonathan C.
   Paulson, Joyce
   Cannarozzi, Maria
   Neer, Sandra M.
   Cassisi, Jeffrey E.
TI Maladaptive Cardiac Autonomic Control during a Stress Reactivity
   Assessment Among Primary Care Patients with Metabolic Syndrome
SO APPLIED PSYCHOPHYSIOLOGY AND BIOFEEDBACK
LA English
DT Article
DE Sympathovagal activity; Cardiac autonomic balance; Cardiac autonomic
   regulation; Impedance cardiography
ID IMPEDANCE CARDIOGRAPHY; SEX-DIFFERENCES; RESPONSES; DISEASE; SPACE
AB Metabolic syndrome (MetS) comprises a constellation of metabolic abnormalities that substantially increase risk for chronic illnesses. Autonomic dysregulation is closely linked to MetS, and while pathophysiological models often address chronic stress exposure, none have examined how such physiological contributions operate situationally, in a clinical setting. We used ambulatory impedance cardiography to examine indicators of cardiac autonomic control (CAC) in a sample of 50 adult primary care patients with and without MetS. Indices of independent sympathetic and parasympathetic cardiovascular control in primary care outpatients were measured during a brief stress reactivity assessment. We compared interdependent CAC features, including cardiac autonomic balance (i.e., sympathovagal reciprocity) and cardiac autonomic regulation (i.e., sympathovagal coactivation) and found significant differences among MetS participants as compared to healthy controls. In particular, cardiac autonomic regulation scores were higher among MetS patients when discussing medication concerns, and cardiac autonomic balance scores were lower among MetS patients when discussing daily stressors. These results suggest that patients meeting criteria for MetS demonstrate momentary variations in CAC depending on personally relevant health topics. The potential for future research is discussed with a focus on prospective data collection to enhance diagnostic procedures and treatment monitoring.
C1 [Mitchell, Jonathan C.; Neer, Sandra M.; Cassisi, Jeffrey E.] Univ Cent Florida, Dept Psychol, Coll Sci, 4111 Pictor Lane, Orlando, FL 32816 USA.
   [Paulson, Joyce; Cannarozzi, Maria] Univ Cent Florida, Coll Med, UCF Hlth, Orlando, FL 32816 USA.
C3 State University System of Florida; University of Central Florida; State
   University System of Florida; University of Central Florida
RP Mitchell, JC (corresponding author), Univ Cent Florida, Dept Psychol, Coll Sci, 4111 Pictor Lane, Orlando, FL 32816 USA.
EM Jonathan.Mitchell@ucf.edu
RI Mitchell, Jonathan/JJC-1266-2023; Cassisi, Jeffrey/S-2974-2018
OI Cassisi, Jeffrey/0000-0003-2288-5690
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NR 37
TC 3
Z9 4
U1 0
U2 3
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1090-0586
EI 1573-3270
J9 APPL PSYCHOPHYS BIOF
JI Appl. Psychophysiol. Biofeedback
PD JUN
PY 2017
VL 42
IS 2
BP 97
EP 105
DI 10.1007/s10484-017-9355-3
PG 9
WC Psychology, Clinical
WE Social Science Citation Index (SSCI)
SC Psychology
GA EW7RR
UT WOS:000402713000003
PM 28251420
DA 2025-06-11
ER

PT J
AU Azizi, M
   Yazdani, F
   Nikbakht, R
   Shahhosseini, Z
AF Azizi, Marzieh
   Yazdani, Fereshteh
   Nikbakht, Roya
   Shahhosseini, Zohreh
TI The Biopsychosocial Outcomes of Childlessness or Having One Child on
   Couple's Health: A Systematic Review
SO JOURNAL OF PEDIATRICS REVIEW
LA English
DT Review
DE Single child; Childlessness; Health outcome; Panel study
ID LIFE; PARENTHOOD; MEN; INFERTILITY; MORTALITY; QUALITY; SUPPORT
AB Background: The increase in childlessness or having one child is one of the significant changes in the demographic structure, especially in developed countries. Literature review shows that having no child or only one child affects the individual's health from various perspectives. Objectives: This study aimed to investigate the biopsychosocial outcomes of childlessness or having one child on couples' health. Methods: In this systematic review, the research question was about the biopsychosocial outcomes of childlessness or having a single child on couples' health. A systematic literature search was done in PubMed, Scopus, Web of Science, ScienceDirect, and the Iranian database, including SID. We employed the following keywords: "Single child," "childlessness," "health outcome," and "panel study." The quality assessment of the included studies was carried out using the Newcastle-Ottawa scale (NOS) for cohort studies. Results: Nine studies were included in this study. The results were analyzed based on the biopsychosocial perspective. From a biological perspective, women with no child or one child and those who had cesarean section showed poorer physical health scores than women with two children and vaginal delivery. Also, other studies showed the impact of childlessness on the higher probability of cardiovascular disease and mortality, metabolic syndrome, and diabetes in men. From a psychological perspective, the studies included in this field had controversial results. Most of the included studies showed that childless women or women with one child had lower scores in mental health compared to women with two children. In addition, women with a cesarean section also had poorer mental health compared to those with vaginal delivery. Also, childlessness in old adults can cause psychological effects such as less life satisfaction, feelings of more anxiety, and loneliness. From a social perspective, one study showed that childless men are different from fathers with children in terms of participation in society, income level, and life satisfaction. Conclusions: The results of this study indicate that childless couples may have various health problems in biological, psychological, and social aspects, which, in general, negatively affect their quality of life. The results of this study can be a good resource for policymakers and health specialists to design and implement cost-effective interventions to improve fertility indicators among the Iranian population.
C1 [Azizi, Marzieh; Shahhosseini, Zohreh] Mazandaran Univ Med Sci, Fac Nursing & Midwifery, Sexual & Reprod Hlth Res Ctr, Dept Midwifery, Sari, Iran.
   [Yazdani, Fereshteh] Mazandaran Univ Med Sci, Hlth Sci Res Ctr, Sari, Iran.
   [Nikbakht, Roya] Mazandaran Univ Med Sci, Fac Hlth, Dept Biostat & Epidemiol, Sari, Iran.
C3 Mazandaran University of Medical Sciences; Mazandaran University of
   Medical Sciences; Mazandaran University of Medical Sciences
RP Shahhosseini, Z (corresponding author), Mazandaran Univ Med Sci, Fac Nursing & Midwifery, Sexual & Reprod Hlth Res Ctr, Dept Midwifery, Sari, Iran.
EM zshahhosseini@yahoo.com
RI Shahhosseini, Zohreh/F-3445-2017
FU Mazandaran University of Medical Sciences, Sari, Iran
FX This study was financially supported by Mazandaran University of Medical
   Sciences, Sari, Iran.
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NR 54
TC 0
Z9 0
U1 0
U2 0
PU MAZANDARAN UNIV MED SCI
PI SARI
PA BOU ALI SINA HOSP, PASDARAN BLVD, SARI, 48158-38477, IRAN
SN 2322-4398
EI 2322-4401
J9 J PEDIAT REV
JI J. Pediat. Rev.
PD JAN
PY 2025
VL 13
IS 1
BP 17
EP 28
DI 10.32598/jpr.13.1.902.3
PG 12
WC Pediatrics
WE Emerging Sources Citation Index (ESCI)
SC Pediatrics
GA 2UX8Q
UT WOS:001491912600003
OA gold
DA 2025-06-11
ER

PT J
AU Laaboub, N
   Dubath, C
   Ranjbar, S
   Sibailly, G
   Grosu, C
   Piras, M
   Délessert, D
   Richard-Lepouriel, H
   Ansermot, N
   Crettol, S
   Vandenberghe, F
   Grandjean, C
   Delacrétaz, A
   Gamma, F
   Plessen, KJ
   von Gunten, A
   Conus, P
   Eap, CB
AF Laaboub, Nermine
   Dubath, Celine
   Ranjbar, Setareh
   Sibailly, Guibet
   Grosu, Claire
   Piras, Marianna
   Delessert, Didier
   Richard-Lepouriel, Helene
   Ansermot, Nicolas
   Crettol, Severine
   Vandenberghe, Frederik
   Grandjean, Carole
   Delacretaz, Aurelie
   Gamma, Franziska
   Plessen, Kerstin Jessica
   von Gunten, Armin
   Conus, Philippe
   Eap, Chin B.
TI Insomnia disorders are associated with increased cardiometabolic
   disturbances and death risks from cardiovascular diseases in psychiatric
   patients treated with weight-gain-inducing psychotropic drugs: results
   from a Swiss cohort
SO BMC PSYCHIATRY
LA English
DT Article
DE Psychiatry; Insomnia disorders; Metabolic syndrome; Metabolic worsening;
   Cardiovascular diseases
ID SHORT-SLEEP DURATION; METABOLIC SYNDROME; EPIDEMIOLOGIC EVIDENCE;
   DAYTIME SLEEPINESS; HYPERTENSION; POPULATION; PREVALENCE; DEPRESSION;
   MORTALITY; CYTOKINES
AB Study objectives Insomnia disorders as well as cardiometabolic disorders are highly prevalent in the psychiatric population compared to the general population. We aimed to investigate their association and evolution over time in a Swiss psychiatric cohort. Methods Data for 2861 patients (8954 observations) were obtained from two prospective cohorts (PsyMetab and PsyClin) with metabolic parameters monitored routinely during psychotropic treatment. Insomnia disorders were based on the presence of ICD-10 "F51.0" diagnosis (non-organic insomnia), the prescription of sedatives before bedtime or the discharge letter. Metabolic syndrome was defined using the International Diabetes Federation definition, while the 10-year risk of cardiovascular event or death was assessed using the Framingham Risk Score and the Systematic Coronary Risk Estimation, respectively. Results Insomnia disorders were observed in 30% of the cohort, who were older, predominantly female, used more psychotropic drugs carrying risk of high weight gain (olanzapine, clozapine, valproate) and were more prone to suffer from schizoaffective or bipolar disorders. Multivariate analyses showed that patients with high body mass index (OR = 2.02, 95%CI [1.51-2.72] for each ten-kg/m(2) increase), central obesity (OR = 2.20, [1.63-2.96]), hypertension (OR = 1.86, [1.23-2.81]), hyperglycemia (OR = 3.70, [2.16-6.33]), high density lipoprotein hypocholesterolemia in women (OR = 1.51, [1.17-1.95]), metabolic syndrome (OR = 1.84, [1.16-2.92]) and higher 10-year risk of death from cardiovascular diseases (OR = 1.34, [1.17-1.53]) were more likely to have insomnia disorders. Time and insomnia disorders were associated with a deterioration of cardiometabolic parameters. Conclusions Insomnia disorders are significantly associated with metabolic worsening and risk of death from cardiovascular diseases in psychiatric patients.
C1 [Laaboub, Nermine; Dubath, Celine; Sibailly, Guibet; Grosu, Claire; Piras, Marianna; Ansermot, Nicolas; Crettol, Severine; Vandenberghe, Frederik; Grandjean, Carole; Delacretaz, Aurelie; Eap, Chin B.] Univ Lausanne, Lausanne Univ Hosp, Dept Psychiat, Unit Pharmacogenet & Clin Psychopharmacol, 1008 Prilly, Lausanne, Switzerland.
   [Ranjbar, Setareh] Univ Lausanne, Univ Lausanne Hosp, Dept Psychiat, Ctr Psychiat Epidemiol & Psychopathol, Lausanne, Switzerland.
   [Delessert, Didier] Univ Lausanne, Univ Lausanne Hosp, Dept Psychiat, Prison Med & Psychiat Serv, Lausanne, Switzerland.
   [Richard-Lepouriel, Helene] Univ Hosp Geneva, Dept Psychiat, Unit Mood Disorders, Geneva, Switzerland.
   [Delacretaz, Aurelie] Les Toises Psychiat & Psychotherapy Ctr, Lausanne, Switzerland.
   [Plessen, Kerstin Jessica] Univ Lausanne, Univ Lausanne Hosp, Dept Psychiat, Serv Child & Adolescent Psychiat, Lausanne, Switzerland.
   [von Gunten, Armin] Univ Lausanne, Univ Lausanne Hosp, Dept Psychiat, Serv Old Age Psychiat, Lausanne, Switzerland.
   [Conus, Philippe] Univ Lausanne, Univ Lausanne Hosp, Dept Psychiat, Serv Gen Psychiat, Lausanne, Switzerland.
   [Eap, Chin B.] Univ Lausanne, Univ Lausanne Hosp, Dept Psychiat, Serv Gen Psychiat, Lausanne, Switzerland.
   [Eap, Chin B.] Univ Lausanne, Ctr Res & Innovat Clin Pharmaceut Sci, Lausanne, Switzerland.
   Univ Lausanne, Univ Geneva, Inst Pharmaceut Sci Western Switzerland, Lausanne, Switzerland.
C3 University of Lausanne; University of Lausanne; Centre Hospitalier
   Universitaire Vaudois (CHUV); University of Lausanne; Centre Hospitalier
   Universitaire Vaudois (CHUV); University of Geneva; University of
   Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV); University of
   Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV); University of
   Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV); University of
   Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV); University of
   Lausanne; University of Lausanne; University of Geneva
RP Eap, CB (corresponding author), Univ Lausanne, Lausanne Univ Hosp, Dept Psychiat, Unit Pharmacogenet & Clin Psychopharmacol, 1008 Prilly, Lausanne, Switzerland.
EM chin.eap@chuv.ch44
RI Frederik, Vandenberghe/IQW-5168-2023; Richard-Lepouriel,
   Hélène/HLX-8031-2023; Ranjbar, Setareh/KRP-6906-2024
OI LAABOUB, Nermine/0000-0001-8029-2418; Grandjean,
   Carole/0009-0002-0460-9182; Richard-Lepouriel,
   Helene/0000-0002-0778-3728; Vandenberghe, Frederik/0000-0002-8964-2047;
   Ranjbar, Setareh/0000-0002-0238-2976
FU Swiss National Research Foundation [320030-120686, 324730-144064,
   320030-173211, 320030-200602]; Swiss National Science Foundation (SNF)
   [320030_173211, 320030_200602] Funding Source: Swiss National Science
   Foundation (SNF)
FX This work has been funded in part by the Swiss National Research
   Foundation (CE and PC: 320030-120686, 324730-144064, and 320030-173211;
   CBE, PC and KJP: 320030-200602). The funding sources had no role in the
   writing of the manuscript or in the decision to submit it for
   publication.
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NR 62
TC 14
Z9 16
U1 1
U2 9
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-244X
J9 BMC PSYCHIATRY
JI BMC Psychiatry
PD MAY 17
PY 2022
VL 22
IS 1
AR 342
DI 10.1186/s12888-022-03983-3
PG 12
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 1I0ZD
UT WOS:000796965400001
PM 35581641
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Solomon, A
   Christian, BF
   Norton, GR
   Woodiwiss, AJ
   Dessein, PH
AF Solomon, Ahmed
   Christian, Berenice F.
   Norton, Gavin R.
   Woodiwiss, Angela J.
   Dessein, Patrick H.
TI Risk Factor Profiles for Atherosclerotic Cardiovascular Disease in Black
   and Other Africans with Established Rheumatoid Arthritis
SO JOURNAL OF RHEUMATOLOGY
LA English
DT Article
DE ATHEROSCLEROTIC CARDIOVASCULAR DISEASE RISK; ETHNIC ORIGIN;
   EPIDEMIOLOGICAL TRANSITION; RHEUMATOID ARTHRITIS
ID CORONARY-HEART-DISEASE; MYOCARDIAL-INFARCTION; SUBCLINICAL
   ATHEROSCLEROSIS; METABOLIC SYNDROME; HEALTH-INSURANCE; PULSE PRESSURE;
   BLOOD-PRESSURE; VASCULAR RISK; MORTALITY; IMPACT
AB Objective. Black Africans reportedly experience a distinctly low risk for atherosclerotic cardiovascular disease (CVD). We investigated whether this protection was present among Africans with established rheumatoid arthritis (RA).
   Methods. We determined disparities in CVD risk factor profiles (major conventional: hypertension, dyslipidemia, smoking, and diabetes; other conventional: underweight, obesity, metabolic syndrome, chronic kidney disease, alcohol consumption, tension, depression, and body height; nonconventional: rheumatoid factor status and markers of inflammation) and arterial stiffness (brachial pulse pressure) between 291 black and 335 other (229 white, 64 Asian, and 42 mixed ancestry) consecutive Africans with RA in multivariable regression models.
   Results. After adjusting for demographic characteristics and healthcare sector attendance, black Africans had more prevalent hypertension (OR 1.76, p = 0.01) and diabetes (OR 1.90, p = 0.07), smoked less frequently (OR 0.12, p < 0.0001), and had concurrent lower total and high-density lipoprotein cholesterol concentrations that resulted in unaltered atherogenic indices (p = 0.2) than the other participants in the study. These findings translated into global scores for major conventional risk factor-mediated future CVD event rates that were not reduced in black patients. Proportions of individual metabolic syndrome components differed between black and other patients but their total numbers of metabolic risk factors (p = 0.4) and metabolic syndrome frequencies (OR 1.44, p = 0.1) were similar. Black ethnicity did not independently associate with rheumatoid factor status, markers of inflammation, and brachial pulse pressures.
   Conclusion. The overall conventional and nonconventional atherosclerotic CVD risk burdens and arterial stiffness were not reduced in black patients with RA. CVD risk should be assessed and managed independent of ethnic origin and epidemiological transition stage in RA. (First Release March 15 2010; J Rheumatol 2010;37:953-60; doi:10.3899/jrheum.091032)
C1 [Solomon, Ahmed; Christian, Berenice F.; Dessein, Patrick H.] Univ Witwatersrand, Dept Rheumatol, ZA-2050 Johannesburg, South Africa.
C3 University of Witwatersrand
RP Dessein, PH (corresponding author), POB 1012, ZA-2109 Johannesburg, South Africa.
EM Dessein@telkomsa.net
RI Dessein, Patrick/AAL-2986-2020
OI Norton, Gavin/0000-0001-6416-6104; , Angela/0000-0003-2555-4125
FU Medical Research Council
FX Supported in part by a Medical Research Council grant.
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NR 51
TC 18
Z9 18
U1 0
U2 4
PU J RHEUMATOL PUBL CO
PI TORONTO
PA 365 BLOOR ST E, STE 901, TORONTO, ONTARIO M4W 3L4, CANADA
SN 0315-162X
EI 1499-2752
J9 J RHEUMATOL
JI J. Rheumatol.
PD MAY
PY 2010
VL 37
IS 5
BP 953
EP 960
DI 10.3899/jrheum.091032
PG 8
WC Rheumatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Rheumatology
GA 596PH
UT WOS:000277696700014
PM 20231201
OA Bronze
DA 2025-06-11
ER

PT J
AU Chen, H
   Hemmingsson, T
   Janszky, I
   Rostila, M
   Forsell, Y
   Meng, LH
   Liang, YJ
   László, KD
AF Chen, Hua
   Hemmingsson, Tomas
   Janszky, Imre
   Rostila, Mikael
   Forsell, Yvonne
   Meng, Linghui
   Liang, Yajun
   Laszlo, Krisztina D.
TI Death of a parent during childhood and blood pressure in youth: a
   population-based cohort study of Swedish men
SO BMJ OPEN
LA English
DT Article
DE hypertension; epidemiology; mental health
ID CORONARY-HEART-DISEASE; LATE ADOLESCENCE; METABOLIC SYNDROME;
   RISK-FACTORS; MIDDLE-AGE; HEALTH; STRESS; HYPERTENSION; EXPERIENCES;
   ADULTHOOD
AB ObjectiveCompelling evidence suggests that childhood adversities are associated with an increased risk of hypertension in middle age and old age. The link between childhood adversities and blood pressure in youth is less clear. In this cohort study, we examined the association between death of a parent during childhood and blood pressure in early adulthood in men.SettingSweden.ParticipantsWe studied 48 624 men born in 1949-1951 who participated in the compulsory military conscription in 1969/1970 in Sweden. Information on death of a parent during childhood was obtained from population-based registers. Information on covariates was obtained from the questionnaire and the clinical examination completed at conscription and from population-based registers.Outcome measuresBlood pressure was measured at conscription according to standard procedures.ResultsThe multivariable least square means of systolic and diastolic blood pressure did not differ between bereaved (128.25 (127.04-129.46) and 73.86 (72.89-74.84) mm Hg) and non-bereaved study participants (128.02 (126.86-129.18) and 73.99 (73.06-74.93) mm Hg). Results were similar when considering the cause of the parent's death, the gender of the deceased parent or the child's age at loss. Loss of a parent in childhood tended to be associated with an increased hypertension risk (OR and 95% CI: 1.10 (1 to 1.20)); the association was present only in case of natural deaths.ConclusionWe found no strong support for the hypothesis that stress following the loss of a parent during childhood is associated with blood pressure or hypertension in youth in men.
C1 [Chen, Hua; Janszky, Imre; Forsell, Yvonne; Meng, Linghui; Liang, Yajun; Laszlo, Krisztina D.] Karolinska Inst, Dept Global Publ Hlth, Stockholm, Sweden.
   [Hemmingsson, Tomas; Rostila, Mikael] Stockholm Univ, Dept Publ Hlth Sci, Stockholm, Sweden.
   [Hemmingsson, Tomas] Karolinska Inst, Inst Environm Med, Stockholm, Sweden.
   [Janszky, Imre] Norwegian Univ Sci & Technol, Fac Med, Dept Publ Hlth & Gen Practice, Trondheim, Norway.
   [Rostila, Mikael] Stockholm Univ, Ctr Hlth Equ Studies, Stockholm, Sweden.
   [Rostila, Mikael] Karolinska Inst, Stockholm, Sweden.
   [Forsell, Yvonne] Stockholm Cty Council, Ctr Epidemiol & Community Med, Stockholm, Sweden.
   [Meng, Linghui] Capital Inst Pediat, Stat Off, Beijing, Peoples R China.
C3 Karolinska Institutet; Stockholm University; Karolinska Institutet;
   Norwegian University of Science & Technology (NTNU); Stockholm
   University; Karolinska Institutet; Region Stockholm; Capital Institute
   of Pediatrics (CIP)
RP Chen, H (corresponding author), Karolinska Inst, Dept Global Publ Hlth, Stockholm, Sweden.
EM hua.chen@ki.se
RI Forsell, Yvonne/ABB-8879-2020
FU Swedish Council for Working Life and Social Research [2015-00837];
   Karolinska Institutet's Research Foundation [2018-01924]; China
   Scholarship Council [201700260296]; Forte [2015-00837] Funding Source:
   Forte
FX The study was supported by the Swedish Council for Working Life and
   Social Research (grant number: 2015-00837), by Karolinska Institutet's
   Research Foundation (grant number: 2018-01924) and by the China
   Scholarship Council (grant number: 201700260296).
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NR 67
TC 2
Z9 2
U1 1
U2 3
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2044-6055
J9 BMJ OPEN
JI BMJ Open
PD APR
PY 2021
VL 11
IS 4
AR e043657
DI 10.1136/bmjopen-2020-043657
PG 11
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 3R2LR
UT WOS:000838750600001
PM 33903141
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Happell, B
   Platania-Phung, C
   Scott, D
AF Happell, B.
   Platania-Phung, C.
   Scott, D.
TI A systematic review of nurse physical healthcare for consumers utilizing
   mental health services
SO JOURNAL OF PSYCHIATRIC AND MENTAL HEALTH NURSING
LA English
DT Article
DE nursing; physical healthcare; planning; serious mental illness;
   systematic review
ID LIFE-STYLE INTERVENTION; WELL-BEING PROGRAM; RANDOMIZED-TRIAL; METABOLIC
   SYNDROME; WEIGHT MANAGEMENT; BIPOLAR DISORDER; OBESE-PATIENTS;
   OLDER-PEOPLE; RISK-FACTORS; ILLNESS
AB The poor physical health of people with serious mental illness presents a long-term public health issue that mental healthcare services, and their most representative group (nurses), can help address. For purposes of long-term planning in increasing the role of nurses in physical healthcare within mental healthcare services a systematic review was conducted of services and programmes where nurses conduct physical healthcare (such as physical health checks and health education). The most common types of physical healthcare represented in the literature were health education, screening, lifestyle programme delivery and co-ordination of care. Although evaluation of the programmes reviewed were all at a preliminary stage, they consistently demonstrated health benefits for consumers.
   AbstractPeople with serious mental illness have higher rates of physical illness and are more likely to experience premature death than the general population. Nurse-led strategies to improve physical healthcare in mental healthcare services could potentially reduce these inequalities. However the extent of nurse involvement in physical healthcare (such as physical risk screening, health education and care co-ordination) in mental health settings is not known. A systematic review was conducted on nurse-led physical healthcare reported for consumers with serious mental illness (SMI) in mental health services, and their benefits. Electronic literature bases (CINAHL, Proquest, PsychINFO and Web of Science) were systematically searched, in conjunction with a manual search of literature reviews on physical healthcare in mental health services. Articles were included if they: (a) were published in the last 10 years; (b) were English language; (c) involved physical healthcare of adult consumers receiving mental healthcare services; and (d) reported nurse involvement in physical healthcare. Forty articles were included in the review. The distribution of types of care were: health education (47%), screening and/or monitoring (33.3%), care co-ordination and management (33.3%), lifestyle programme delivery (30.5%), follow-up actions to screening results (25%) and registers and data administration (5.5%). Overall, the evaluation of nurse-based physical healthcare is in early stages. Thus far, they appear to have positive implications for consumers with SMI.
C1 [Happell, B.; Platania-Phung, C.; Scott, D.] Cent Queensland Univ, Inst Hlth & Social Sci Res, Ctr Mental Hlth Nursing Innovat, Rockhampton, Qld 4702, Australia.
   [Happell, B.] Cent Queensland Univ, Sch Nursing & Midwifery, Rockhampton, Qld 4702, Australia.
C3 Central Queensland University; Central Queensland University
RP Happell, B (corresponding author), Cent Queensland Univ, Rockhampton, Qld 4702, Australia.
EM b.happell@cqu.edu.au
RI Scott, David/AAE-5031-2021; Happell, Brenda/HSI-0570-2023
OI Happell, Brenda/0000-0002-7293-6583; Scott, David/0000-0001-5226-1972
FU Central Queensland University
FX The authors acknowledge the financial support for this work provided by
   Central Queensland University.
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NR 69
TC 22
Z9 24
U1 0
U2 31
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1351-0126
EI 1365-2850
J9 J PSYCHIATR MENT HLT
JI J. Psychiatr. Ment. Health Nurs.
PD FEB
PY 2014
VL 21
IS 1
BP 11
EP 22
DI 10.1111/jpm.12041
PG 12
WC Nursing; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Psychiatry
GA 278NA
UT WOS:000328895800002
PM 23419025
DA 2025-06-11
ER

PT J
AU Talari, HR
   Najafi, V
   Raygan, F
   Mirhosseini, N
   Ostadmohammadi, V
   Amirani, E
   Taghizadeh, M
   Hajijafari, M
   Shafabakhash, R
   Asemi, Z
AF Talari, Hamid Reza
   Najafi, Vahid
   Raygan, Fariba
   Mirhosseini, Naghmeh
   Ostadmohammadi, Vahidreza
   Amirani, Elaheh
   Taghizadeh, Mohsen
   Hajijafari, Mohammad
   Shafabakhash, Rana
   Asemi, Zatollah
TI Long-term vitamin D and high-dose n-3 fatty acids'
   supplementation improve markers of cardiometabolic risk in type 2
   diabetic patients with CHD (Publication with Expression of Concern. See
   vol. 127, pg. 158, 2022)
SO BRITISH JOURNAL OF NUTRITION
LA English
DT Article; Publication with Expression of Concern
DE Vitamin D supplementation; n-3 Fatty acids; Cardiometabolic risk; Type 2
   diabetes mellitus; Coronary heart disease
ID INTIMA-MEDIA THICKNESS; CORONARY-HEART-DISEASE; FLAXSEED OIL;
   DOUBLE-BLIND; TRANSCRIPTIONAL ACTIVATION; ENDOTHELIAL DYSFUNCTION;
   OXIDATIVE STRESS; ATHEROSCLEROSIS; INFLAMMATION; GLUCOSE
AB This study was performed to evaluate the effects of vitamin D and n-3 fatty acids' co-supplementation on markers of cardiometabolic risk in diabetic patients with CHD. This randomised, double-blinded, placebo-controlled trial was conducted among sixty-one vitamin D-deficient diabetic patients with CHD. At baseline, the range of serum 25-hydroxyvitamin D levels in study participants was 6 center dot 3-19 center dot 9 ng/ml. Subjects were randomly assigned into two groups either taking 50 000 IU vitamin D supplements every 2 weeks plus 2x 1000 mg/d n-3 fatty acids from flaxseed oil (n 30) or placebo (n 31) for 6 months. Vitamin D and n-3 fatty acids' co-supplementation significantly reduced mean (P = 0 center dot 01) and maximum levels of left carotid intima-media thickness (CIMT) (P = 0 center dot 004), and mean (P = 0 center dot 02) and maximum levels of right CIMT (P = 0 center dot 003) compared with the placebo. In addition, co-supplementation led to a significant reduction in fasting plasma glucose (beta -0 center dot 40 mmol/l; 95 % CI -0 center dot 77, -0 center dot 03; P = 0 center dot 03), insulin (beta -1 center dot 66 mu IU/ml; 95 % CI -2 center dot 43, -0 center dot 89; P < 0 center dot 001), insulin resistance (beta -0 center dot 49; 95 % CI -0 center dot 72, -0 center dot 25; P < 0 center dot 001) and LDL-cholesterol (beta -0 center dot 21 mmol/l; 95 % CI -0 center dot 41, -0 center dot 01; P = 0 center dot 04), and a significant increase in insulin sensitivity (beta +0 center dot 008; 95 % CI 0 center dot 004, 0 center dot 01; P = 0 center dot 001) and HDL-cholesterol (beta +0 center dot 09 mmol/l; 95 % CI 0 center dot 01, 0 center dot 17; P = 0 center dot 02) compared with the placebo. Additionally, high-sensitivity C-reactive protein (beta -1 center dot 56 mg/l; 95 % CI -2 center dot 65, -0 center dot 48; P = 0 center dot 005) was reduced in the supplemented group compared with the placebo group. Overall, vitamin D and n-3 fatty acids' co-supplementation had beneficial effects on markers of cardiometabolic risk.
C1 [Talari, Hamid Reza; Najafi, Vahid] Kashan Univ Med Sci, Dept Radiol, Kashan, Iran.
   [Raygan, Fariba] Kashan Univ Med Sci, Dept Cardiol, Sch Med, Kashan, Iran.
   [Mirhosseini, Naghmeh] Univ Saskatchewan, Sch Publ Hlth, Saskatoon, SK, Canada.
   [Ostadmohammadi, Vahidreza; Amirani, Elaheh; Taghizadeh, Mohsen; Shafabakhash, Rana; Asemi, Zatollah] Kashan Univ Med Sci, Res Ctr Biochem & Nutr Metab Dis, Kashan, Iran.
   [Hajijafari, Mohammad] Kashan Univ Med Sci, Trauma Res Ctr, Kashan, Iran.
C3 University of Saskatchewan
RP Asemi, Z (corresponding author), Kashan Univ Med Sci, Res Ctr Biochem & Nutr Metab Dis, Kashan, Iran.
EM asemi_r@yahoo.com
RI asemi, zatollah/J-2677-2018; Hajijafari, Mohammad/H-4119-2017;
   Mirhosseini, Naghmeh/AAC-7730-2019; Raygan, Fariba/W-3349-2017;
   Taghizadeh, Mohsen/D-7784-2017; Ostadmohammadi, Vahidreza/A-6248-2018
OI Raygan, Fariba/0000-0003-3789-5584; Ostadmohammadi,
   Vahidreza/0000-0002-4633-5397
FU KAUMS, Iran
FX The present study was funded by a grant from the Vice-Chancellor for
   Research, KAUMS, Iran.
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NR 59
TC 20
Z9 20
U1 1
U2 9
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1145
EI 1475-2662
J9 BRIT J NUTR
JI Br. J. Nutr.
PD AUG 28
PY 2019
VL 122
IS 4
BP 423
EP 430
AR PII S0007114519001132
DI 10.1017/S0007114519001132
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA IW9PS
UT WOS:000485326300006
PM 31309919
OA Bronze
DA 2025-06-11
ER

PT J
AU Simao, ANC
   Lehmann, MF
   Alfieri, DF
   Meloni, MZ
   Flauzino, T
   Scavuzzi, BM
   de Oliveira, SR
   Lozovoy, MAB
   Dichi, I
   Reiche, EMV
AF Colado Simao, Andrea Name
   Lehmann, Marcio Francisco
   Alfieri, Daniela Frizon
   Meloni, Milena Zardetto
   Flauzino, Tamires
   Scavuzzi, Bruna Miglioranza
   de Oliveira, Sayonara Rangel
   Batisti Lozovoy, Marcell Alysson
   Dichi, Isaias
   Vissoci Reiche, Edna Maria
TI Metabolic syndrome increases oxidative stress but does not influence
   disability and short-time outcome in acute ischemic stroke patients
SO METABOLIC BRAIN DISEASE
LA English
DT Article
DE Stroke; Oxidative stress; Metabolic syndrome; Disability; Modified
   Rankin scale
ID ANTIOXIDANT CAPACITY; DENSITY-LIPOPROTEIN; INSULIN-RESISTANCE;
   URIC-ACID; RISK; HEART; ALBUMIN; MARKERS; BLOOD; INFLAMMATION
AB Oxidative stress has been implicated in the pathophysiology of cardiovascular disease and MetS and it may be one of molecular mechanisms involved in stroke. The aims of the present study were to verify differences in oxidative stress markers in acute ischemic stroke patients with and without MetS and to verify whether MetS influences disability and short time outcome of the patients. 148 patients with acute ischemic stroke were divided in two groups: with MetS (n = 92) and without MetS (n = 56). The modified Rankin Scale (mRS) was used for measuring the functional disability after 3-month follow-up. The study assessed the metabolic profile and oxidative stress markers. Stroke patients with MetS had higher levels of lipid hydroperoxides (p < 0.0001) and advanced oxidation protein products (AOPP, p = 0.0302) than those without MetS. Hydroperoxides were directly and independently associated with MetS (OR: 1.000, 95 % IC = 1.000-1.000, p = 0.005). Linear regression demonstrated that AOPP levels (R-2 = 0.281, p < 0.0001) and oxidative stress index (OSI, R-2 = 0.223, p < 0.0001) were directly associated with triglycerides levels and hydroperoxides levels was also directly associated with glucose levels (R-2 = 0.080, p = 0.013. The mRS and short-come outcome did not differ after 3 months in both groups. In conclusion, an increase in oxidative stress markers was shown in acute ischemic stroke patients with MetS and this elevation seems to be involved mainly with changes in lipid profile, but the presence of MetS did not influence short-time disability and survival of the acute ischemic stroke patients.
C1 [Colado Simao, Andrea Name; Alfieri, Daniela Frizon; Meloni, Milena Zardetto; Flauzino, Tamires; Scavuzzi, Bruna Miglioranza; Batisti Lozovoy, Marcell Alysson; Vissoci Reiche, Edna Maria] Univ Estadual Londrina, Dept Clin Pathol Clin Anal & Toxicol, BR-86038440 Londrina, Parana, Brazil.
   [Lehmann, Marcio Francisco] Univ Londrina, Dept Neurol Surg, Londrina, Parana, Brazil.
   [de Oliveira, Sayonara Rangel] Univ North Parana UNOPAR, Dept Clin Anal, Londrina, Parana, Brazil.
   [Dichi, Isaias] Univ Londrina, Dept Internal Med, Londrina, Parana, Brazil.
C3 Universidade Estadual de Londrina; University Norte Parana
RP Simao, ANC (corresponding author), Univ Estadual Londrina, Dept Clin Pathol Clin Anal & Toxicol, Robert Koch Ave 60, BR-86038440 Londrina, Parana, Brazil.
EM deianame@yahoo.com.br
RI Reiche, EDNa/AAD-4186-2020; Scavuzzi, Bruna/AAK-7916-2020; Alfieri,
   Daniela/LSI-6403-2024; Simão, Andrea/AAM-4892-2021; Lozovoy,
   Marcell/AAM-4897-2021; Reiche, Edna Maria Vissoci/C-4102-2013
OI Alfieri, Daniela/0000-0002-0217-9329; Miglioranza Scavuzzi,
   Bruna/0000-0001-9609-001X; Reiche, Edna Maria
   Vissoci/0000-0001-6507-2839
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NR 49
TC 14
Z9 14
U1 0
U2 4
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0885-7490
EI 1573-7365
J9 METAB BRAIN DIS
JI Metab. Brain Dis.
PD DEC
PY 2015
VL 30
IS 6
BP 1409
EP 1416
DI 10.1007/s11011-015-9720-y
PG 8
WC Endocrinology & Metabolism; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology
GA CW6DB
UT WOS:000365086600011
PM 26342606
DA 2025-06-11
ER

PT J
AU Koch, DA
   Scott, AJ
AF Koch, D. A.
   Scott, A. J.
TI Weight gain and lipid-glucose profiles among patients taking
   antipsychotic medications: comparisons for prescriptions administered
   using algorithms versus usual care
SO JOURNAL OF PSYCHIATRIC AND MENTAL HEALTH NURSING
LA English
DT Article
DE algorithm; antipsychotic; criteria; evidence-based practice; metabolic;
   prescribing
AB The purpose of this study was to determine if treatment strategy had a significant effect on the occurrence of physiological changes consistent with metabolic syndrome and/or type 2 diabetes in patients using atypical antipsychotic medications. The four variables assessed were: weight gain, fasting blood sugar, triglycerides and cholesterol. The two strategies compared were (1) evidence-based practice, derived from the Texas Medication Algorithm Project, and (2) practitioner preference. A retrospective chart review was performed on patients diagnosed with a chronic psychiatric disorder being treated with atypical antipsychotics. The dates of the reviewed records were from 1 January 2008 to 31 December 2008. The sample of patients totaled 113. Statistical analysis included logistic regression for each of the four variables assessed. The use of evidence-based practice guidelines was found to have strong positive effects on two of the four variables assessed. Further studies need to be conducted to include medications being taken to lower lipids and blood sugar. Overall, the use of evidence-based practice guidelines has a positive effect on weight, triglycerides and cholesterol. It is important that patients be closely monitored and changes made in a timely manner to minimize adverse effects of atypical antipsychotics.
C1 [Koch, D. A.] Univ Arkansas Ft Smith, Ft Smith, AR 72913 USA.
   [Scott, A. J.] Univ Arkansas, Fayetteville, AR 72701 USA.
C3 University of Arkansas System; University of Arkansas Fort Smith;
   University of Arkansas System; University of Arkansas Fayetteville
RP Koch, DA (corresponding author), Univ Arkansas Ft Smith, 5210 Grand Ft Smith Ave, Ft Smith, AR 72913 USA.
EM arlouko@cox.net
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NR 12
TC 4
Z9 7
U1 0
U2 4
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1351-0126
J9 J PSYCHIATR MENT HLT
JI J. Psychiatr. Ment. Health Nurs.
PD JUN
PY 2012
VL 19
IS 5
BP 389
EP 394
DI 10.1111/j.1365-2850.2011.01781.x
PG 6
WC Nursing; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Psychiatry
GA 934KC
UT WOS:000303442000003
PM 22070226
DA 2025-06-11
ER

PT J
AU Hulsmans, M
   Holvoet, P
AF Hulsmans, Maarten
   Holvoet, Paul
TI The vicious circle between oxidative stress and inflammation in
   atherosclerosis
SO JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
LA English
DT Review
DE atherosclerosis; metabolic syndrome; diabetes; inflammation; oxidative
   stress; adipose tissue; vascular tissue; oxidized LDL
ID LOW-DENSITY-LIPOPROTEIN; CORONARY-HEART-DISEASE; ADIPOSE-TISSUE
   INFLAMMATION; SMOOTH-MUSCLE-CELLS; C-REACTIVE PROTEIN; METABOLIC
   SYNDROME; OXIDIZED LDL; INSULIN-RESISTANCE; CARDIOVASCULAR-DISEASE;
   PHOSPHOLIPASE A(2)
AB Introduction
   Overview of molecular mechanisms explaining the association of inflammation and oxidative stress in the vessel wall
   Regulatory mechanisms of interactions between oxidative stress and inflammation
   Overview of molecular mechanisms explaining the association of inflammation and oxidative stress in adipose tissues
   Conclusions
   The initial event in atherogenesis is the increased transcytosis of low density lipoprotein, and its subsequent deposition, retention and modification in the subendothelium. It is followed by the infiltration of activated inflammatory cells from the coronary circulation into the arterial wall. There they secrete reactive oxygen species (ROS) and produce oxidized lipoproteins capable of inducing endothelial cell apoptosis, and thereby plaque erosion. Activated T lymphocytes, macrophages and mast cells, accumulate in the eroded plaque where they secrete a variety of proteases capable of inducing degradation of extracellular proteins, thereby rendering the plaques more prone to rupture. This review summarizes the recent advancements in the understanding of the roles of ROS and oxidized lipoproteins in the activation of inflammatory cells and inducing signalling pathways related to cell death and apoptosis. In addition, it presents evidence that this vicious circle between oxidative stress and inflammation does not only occur in the diseased arterial wall, but also in adipose tissues. There, oxidative stress and inflammation impair adipocyte maturation resulting in defective insulin action and adipocytokine signalling. The latter is associated with increased infiltration of inflammatory cells, loss of anti-oxidant protection and cell death in the arterial wall.
C1 [Hulsmans, Maarten; Holvoet, Paul] Katholieke Univ Leuven, Dept Cardiovasc Dis, Atherosclerosis & Metab Unit, B-3000 Louvain, Belgium.
C3 KU Leuven
RP Holvoet, P (corresponding author), Katholieke Univ Leuven, Dept Cardiovasc Dis, Atherosclerosis & Metab Unit, Herestr 49,O&N1,PB 705, B-3000 Louvain, Belgium.
EM paul.holvoet@med.kuleuven.be
RI HOLVOET, PAUL/T-8434-2017; Hulsmans, Maarten/AAI-9547-2020
OI Holvoet, Paul/0000-0001-9201-0772; Hulsmans, Maarten/0000-0003-1009-658X
FU Interuniversitaire Attractiepolen Programma of the Belgian Federal
   Government [P06/30]; Bijzonder Onderzoeksfonds of the Katholieke
   Universiteit Leuven [OT/06/56]; Fonds voor Wetenschappelijk
   Onderzoek-Vlaanderen (Vascular Biology Network)
FX Funding was provided by the Interuniversitaire Attractiepolen Programma
   of the Belgian Federal Government (P06/30), the Bijzonder
   Onderzoeksfonds of the Katholieke Universiteit Leuven (OT/06/56) and by
   the Fonds voor Wetenschappelijk Onderzoek-Vlaanderen (Vascular Biology
   Network).
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NR 75
TC 213
Z9 239
U1 0
U2 29
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1582-1838
EI 1582-4934
J9 J CELL MOL MED
JI J. Cell. Mol. Med.
PD JAN-FEB
PY 2010
VL 14
IS 1-2
BP 70
EP 78
DI 10.1111/j.1582-4934.2009.00978.x
PG 9
WC Cell Biology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Research & Experimental Medicine
GA 569YV
UT WOS:000275639700006
PM 19968738
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU de la Torre-luque, A
   Pemau, A
   Galvez-Merlin, A
   Garcia-Ramos, A
AF de la Torre-luque, Alejandro
   Pemau, Andres
   Galvez-Merlin, Alejandra
   Garcia-Ramos, Adriana
TI Immunometabolic alterations in older adults with heightened depressive
   symptom trajectories: a network approach
SO AGING & MENTAL HEALTH
LA English
DT Article
DE Depression; late life; inflammation; metabolic markers; loneliness;
   network analysis
ID LATE-LIFE DEPRESSION; ASSOCIATION; DISEASE; CONNECTIVITY; HYPERTENSION;
   METAANALYSIS; LONELINESS; MORTALITY; AGE
AB Objective: To analyse the patterns of relationships between depressive symptoms and immunometabolic markers across longitudinal depression status in older people. Methods: A sample of 3349 older adults (55.21% women; initial age: m = 58.44, sd = 5.21) from the English Longitudinal Study of Ageing was used. Participants were classified according to their longitudinal depression status: minimal depressive symptoms (n = 2736), depressive episode onset (n = 481), or chronic depression (n = 132). Network analysis was used to study the relationships between depression symptoms (CES-D 8 items), inflammatory (white blood cell, C-reactive protein, fibrinogen) and metabolic biomarkers (metabolic syndrome markers). Results: Network structure remained invariant across groups. The minimal symptom group had higher overall strength than both clinical groups (p < .01). Moreover, significant relationships between symptoms and markers were observed across group-specific networks. C-reactive protein and effort symptom were positively connected in the minimal symptom group but not in the other groups. Loneliness and diastolic blood pressure were positively associated only in the chronic depression group. Finally, metabolic markers were identified as central nodes in the clinical status networks. Conclusion: The network analysis constitutes a useful approach to disentangle pathophysiological relationships that may maintain mental disorders in old age.
C1 [de la Torre-luque, Alejandro; Garcia-Ramos, Adriana] Univ Complutense Madrid, Dept Legal Med Psychiat & Pathol, Madrid, Spain.
   [de la Torre-luque, Alejandro] Ctr Biomed Res Mental Hlth CIBERSAM, Madrid, Spain.
   [Pemau, Andres; Galvez-Merlin, Alejandra] Univ Complutense Madrid, Fac Psychol, Madrid, Spain.
C3 Complutense University of Madrid; CIBER - Centro de Investigacion
   Biomedica en Red; CIBERSAM; Complutense University of Madrid
RP Pemau, A (corresponding author), Univ Complutense Madrid, Fac Psychol, Madrid, Spain.
EM apemau@ucm.es
RI de la Torre-Luque, Alejandro/AAJ-3508-2020; Pemau, Andrés/AHB-4203-2022;
   Pemau, Andres/HNJ-3824-2023
OI Garcia-Ramos, Adriana/0000-0002-3246-9917; Pemau,
   Andres/0000-0002-5835-507X
FU U.S. National Institute of Aging; National Centre for Social Research;
   University College London (UCL); Instituto de Salud Carlos III-FIS
   [PI20/00229]; European Regional Development Fund (ERDF) "A Way to Build
   Europe"
FX The ELSA study is supported by the U.S. National Institute of Aging, the
   National Centre for Social Research, the University College London (UCL)
   and the Institute for Fiscal Studies. The authors gratefully acknowledge
   the UK Data Service and UCL who provided data for this paper. This study
   was supported by the Instituto de Salud Carlos III-FIS research grant
   PI20/00229, co-funded by the European Regional Development Fund (ERDF)
   "A Way to Build Europe".
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NR 61
TC 0
Z9 0
U1 4
U2 20
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 1360-7863
EI 1364-6915
J9 AGING MENT HEALTH
JI Aging Ment. Health
PD NOV 2
PY 2023
VL 27
IS 11
BP 2229
EP 2237
DI 10.1080/13607863.2023.2227114
EA JUN 2023
PG 9
WC Geriatrics & Gerontology; Gerontology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Psychiatry
GA FP1V1
UT WOS:001022982300001
PM 37401624
DA 2025-06-11
ER

PT J
AU Dixon, JB
   Schachter, LM
   O'Brien, PE
AF Dixon, JB
   Schachter, LM
   O'Brien, PE
TI Polysomnography before and after weight loss in obese patients with
   severe sleep apnea
SO INTERNATIONAL JOURNAL OF OBESITY
LA English
DT Article
DE sleep; weight loss; gastric; banding; comorbidity; metabolic syndrome;
   quality of life
ID QUALITY-OF-LIFE; GASTRIC BYPASS; HEALTH; SURGERY
AB OBJECTIVE: While obstructive sleep apnea (OSA) is strongly related to obesity, few studies have examined polysomnographic (PSG) changes with major weight loss. We examined the effect of weight loss following laparoscopic adjustable gastric banding (LAGB) on the PSG changes in patients with severe OSA. In addition, we studied daytime sleepiness, the metabolic syndrome and quality of life (QOL).
   METHODS: A prospective study was conducted of 25 severely obese patients (17 men, eight women) with paired diagnostic PSG, biochemical and questionnaire studies, the first prior to LAGB and the second at least 1y later. Subjects with a baseline apnea-hypopnea index (AHI) > 25/h were included.
   RESULTS: Subject baseline age was 44.7 y, weight 154 kg and body mass index 52.7 kg/m(2). The second PSG study was conducted 17.7 +/- 10 (range 12-42) months after surgery and mean percentage of excess loss and weight loss were 50.1 +/- 15% (range 24-80%) and 44.9 +/- 22 kg ( range 18-103 kg), respectively. There was a significant fall in AHI from 61.6 +/- 34 to 13.4 +/- 13, improved sleep architecture with increased REM and stage III and IV sleep, daytime sleepiness, as measured by Epworth Sleepiness Scale, of 13 +/- 7.0 to 3.8 +/- 3.0, and fewer patients requiring nasal continuous positive airways pressure (CPAP). There were also major improvements in the metabolic syndrome, QOL, body image and fewer symptoms of depression (P < 0.05 for all).
   CONCLUSION: Weight loss provides major improvement or resolution of OSA and CPAP requirements. It also reduces daytime sleepiness, and improves the metabolic syndrome and QOL. LAGB placement should be considered a broadly effective therapy for sleep apnea in the severely obese patient.
C1 Monash Univ, Alfred Hosp, Ctr Obes Res & Educ, Melbourne, Vic 3004, Australia.
C3 Florey Institute of Neuroscience & Mental Health; Howard Florey
   Institute Affiliates; Monash University
RP Monash Univ, Alfred Hosp, Ctr Obes Res & Educ, Melbourne, Vic 3004, Australia.
EM john.dixon@med.monash.edu.au
RI Dixon, John/A-5318-2011
OI Dixon, John/0000-0001-6399-7010
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NR 42
TC 113
Z9 124
U1 0
U2 5
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0307-0565
EI 1476-5497
J9 INT J OBESITY
JI Int. J. Obes.
PD SEP
PY 2005
VL 29
IS 9
BP 1048
EP 1054
DI 10.1038/sj.ijo.0802960
PG 7
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 954CC
UT WOS:000231130700004
PM 15852048
DA 2025-06-11
ER

PT J
AU Dabek, J
   Kulach, A
   Wilczok, T
   Mazurek, U
   Jakubowski, D
   Gasior, Z
AF Dabek, Jozefa
   Kulach, Andrzej
   Wilczok, Tadeusz
   Mazurek, Urszula
   Jakubowski, Daniel
   Gasior, Zbigniew
TI Transcriptional activity of genes encoding interferon γ (IFNγ) and its
   receptor assessed in peripheral blood mononuclear cells in patients with
   cardiac syndrome X
SO INFLAMMATION
LA English
DT Article
DE interferon gamma; interferon receptor; cardiac syndrome X; gene
   expression
ID LEFT-VENTRICULAR FUNCTION; CORONARY-ARTERY-DISEASE; DYSFUNCTION;
   ACTIVATION; PROGNOSIS; APOPTOSIS
AB Background. Cardiac syndrome X is typically characterized by effort induced anginal pain with ST segment depression suggestive of myocardial ischemia and normal coronary arteries at angiography. The possible mechanism that may participate in the pathology of CSX is a microvascular dysfunction related to inflammatory process affecting endothelium. Interferon gamma (IFN-gamma) is an important cytokine in inflammatory reaction. It acts through its specific receptor composed of 2 subunitsIFN-gamma R1 (ligand binding) and R2 (signal transduction). The expression and proportion of these subunits influences IFN-gamma activity. The aim of the study was to assess the gene expression of IFN-gamma and its receptors in peripheral blood mononuclear cells (PBMC) from patients with syndrome X.
   Methods. The study was carried out in 36 patients aged 44-77 (average 57 years old) with cardiac syndrome X and 23 sex- and age-matched healthy subjects (control group). To evaluate gene expression of IFN gamma and its receptor total mRNA was extracted from peripheral blood mononuclear cells (PBMC) and the number of mRNA copies were assessed by quantitive reverse transcriptase polymerase chain reaction (QRT- PCR).
   Results. We have not observed statistically significant differences in INF gamma gene expression between studied group and control. Genes encoding IFN gamma receptor subunits showed higher expression in PBMCs from patients with cardiac syndrome X vs control subjects (IFN gamma R1, 97,244 +/- 26,956 c/mu g vs 12,120 +/- 2,940 c/mu g, p < 0.005, respectively and IFN gamma R2, 129,153 +/- 36,883 c/mu g vs 16,445 +/- 2,923 c/mu g, p < 0.005, respectively).
   Conclusion. Variation in transcriptional activity of genes encoding INF-gamma receptor subunits may affect function of microvasculature and thereby participate in the pathology of cardiac syndrome X.
C1 L Warynski Silesian Med Acad, Dept Cardiol, PL-40635 Katowice, Poland.
   L Warynski Silesian Med Acad, Dept Mol Genet & Med Genet, Sosnowiec, Poland.
C3 Medical University of Silesia; Medical University of Silesia
RP Kulach, A (corresponding author), L Warynski Silesian Med Acad, Dept Cardiol, Ziolowa 47, PL-40635 Katowice, Poland.
EM akulach@mp.pl
RI Kulach, Andrzej/ABF-3313-2020
OI Kulach, Andrzej/0000-0002-3140-1806
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NR 21
TC 10
Z9 13
U1 0
U2 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0360-3997
J9 INFLAMMATION
JI Inflammation
PD AUG
PY 2007
VL 30
IS 3-4
BP 125
EP 129
DI 10.1007/s10753-007-9028-0
PG 5
WC Cell Biology; Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Immunology
GA 181HM
UT WOS:000247427800006
PM 17546485
DA 2025-06-11
ER

PT J
AU Hong, KH
   Lee, Y
AF Hong, Ki-Hong
   Lee, Young
TI Negative Correlation Between Vitamin A and Positive Correlation Between
   Vitamin E and Inflammation Among Healthy Adults in Korea: Based on the
   Korea National Health and Nutrition Examination Survey (KNHANES)
   2016-2018 7th Edition
SO JOURNAL OF INFLAMMATION RESEARCH
LA English
DT Article
DE metabolic syndrome; retinol; alpha-tocopherol; smoking; drinking
ID GENDER-RELATED DIFFERENCES; SERUM ALPHA-TOCOPHEROL; GAMMA-TOCOPHEROL;
   RETINOIC ACID; ALCOHOL-CONSUMPTION; OXIDATIVE STRESS; AIR-POLLUTION;
   PROTEIN; OBESITY; SUPPLEMENTATION
AB Purpose: Vitamins exert its effect through different isoforms. The isoform conversion phases involved are affected outside factors. Here, we investigated the correlation between serum retinol, alpha-tocopherol, and serum inflammatory markers using stratified data acquired from 2016 to 2018 Korea National Health and Nutrition Examination Survey (KNHANES).
   Materials and Methods: This study was based on data acquired from the 7th edition (2016-2018) of the Korea National Health and Nutrition Examination Survey, consisting of survey data on smoking and alcohol drinking, serum retinol level, serum alpha-tocopherol level, high-sensitivity C-reactive protein (hs-CRP), and baseline characteristics.
   Results: There was a negative correlation between serum retinol and hs-CRP in alcohol drinking men. There was a negative correlation between serum retinol and hs-CRP in the alcohol-nonsmoking female group. There was a positive correlation between alpha-tocopherol and hs-CRP in the nonsmoking and alcohol-drinking group. There was a positive correlation between alpha-tocopherol and hs-CRP in the nonsmoking and alcohol-drinking female group. There was positive correlation between vitamin A and E and metabolic syndrome. The lowest vitamin A level was observed in subjects with all five metabolic syndrome criteria matched.
   Conclusion: There was a negative correlation between serum retinol and hs-CRP and positive correlation between alpha-tocopherol and hs-CRP. Absorption and secretion of serum retinol are affected by inflammation status through retinol-binding protein. Alcohol acts as a competitive inhibitor of vitamin A oxidation through alcohol dehydrogenase and ALDH activity. Smoking causes inflammation and induces reactive oxygen species scavenging system and increases cytochrome p450 levels. These factors may have contributed to the observed findings. Metabolic syndrome subjects increased as the levels of vitamin A and vitamin E increased. Since obesity is inversely related to ALDH activity, we postulate that patients with metabolic syndrome may also have low ALDH activity, especially in the Asian population. Future studies are warranted to study the efficacy of ALDH or ALDH inducers in patients with vitamin A deficiency or metabolic syndrome.
C1 [Hong, Ki-Hong] Seoul Vet Hosp, Nursing Hosp, Dept Family Med, 53,Jinhwangdo Ro 61 Gil, Seoul 05368, South Korea.
   [Lee, Young] Vet Hlth Serv Med Ctr, Vet Med Res Inst, Seoul 05368, South Korea.
C3 Seoul Veterans Hospital; Veterans Health Service Medical Center
RP Hong, KH (corresponding author), Seoul Vet Hosp, Nursing Hosp, Dept Family Med, 53,Jinhwangdo Ro 61 Gil, Seoul 05368, South Korea.
EM hkhtech@naver.com
RI Hong, Kihong/AAN-6883-2021
OI Hong, Kihong/0000-0001-6054-1456
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NR 45
TC 6
Z9 7
U1 1
U2 3
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
EI 1178-7031
J9 J INFLAMM RES
JI J. Inflamm. Res.
PY 2020
VL 13
BP 799
EP 811
DI 10.2147/JIR.S265856
PG 13
WC Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology
GA OO8UY
UT WOS:000587650900001
PM 33154657
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Lahouel, A
AF Lahouel, Asma
TI High sugar consumption for seven days in adult mice increased blood
   glucose variability, induced an anxiolytic effect and triggered
   oxidative stress in cerebral cortex
SO METABOLIC BRAIN DISEASE
LA English
DT Article
DE Brain; Glucose variability; Sucrose; Oxidative stress; Anxiolytic
   behavior
ID SPRAGUE-DAWLEY RATS; SHORT-TERM; ALZHEIMERS-DISEASE; METABOLIC SYNDROME;
   CAFETERIA DIET; ANXIETY; BRAIN; HIPPOCAMPUS; BEHAVIORS; FRUCTOSE
AB Brain function is highly altered by glucose toxicity related to diabetes. High consumption of sugar in normal conditions is suspected to affect as well brain integrity. The present study investigates the possible effects of short-term exposure to high sugar diet on brain redox homeostasis in healthy mice. Male adult healthy mice were divided into two groups: control (CG) and sugar-exposed group (SG), that was exposed continually to 10% of glucose in drinking water for 7 days and 20% sucrose pellets food. Behavior, blood glucose variability and cerebral cortex oxidative stress biomarkers were measured at the end of exposure. Animals exposed to the high sugar diet expressed a significant increase in blood glucose levels and high glucose variability compared to control. These animals expressed as well anxiolytic behavior as revealed by the plus maze test. Exposure to the sugar diet altered redox homeostasis in the brain cortex as revealed by an increase in lipid peroxidation and the activity of antioxidant enzymes superoxide dismutase (SOD) and glutathione-s-transferase (GST). On the other hand, catalase (CAT) activity was decreased, and reduced glutathione (GSH) level was not altered compared to control. Further studies are required to understand the mechanisms trigging oxidative stress (OS) in the brain in response to short term exposure to high sugar diet and glucose fluctuations.
C1 [Lahouel, Asma] Univ Jijel, Fac Exact Sci & Comp Sci, Lab Pharmacol & Phytochemistry, Jijel 18000, Algeria.
   [Lahouel, Asma] Univ Jijel, Fac Nat & Life Sci, Dept Mol & Cellular Biol, Jijel 18000, Algeria.
C3 Universite de Jijel; Universite de Jijel
RP Lahouel, A (corresponding author), Univ Jijel, Fac Exact Sci & Comp Sci, Lab Pharmacol & Phytochemistry, Jijel 18000, Algeria.; Lahouel, A (corresponding author), Univ Jijel, Fac Nat & Life Sci, Dept Mol & Cellular Biol, Jijel 18000, Algeria.
EM Asma.lahouel@univ-jijel.dz
FU Algerian Directorate-General for Scientific Research and Technological
   Development (DGRSDT)
FX The author acknowledges the Algerian Directorate-General for Scientific
   Research and Technological Development (DGRSDT) for providing support
   during the preparation of this work.
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NR 51
TC 1
Z9 1
U1 0
U2 0
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0885-7490
EI 1573-7365
J9 METAB BRAIN DIS
JI Metab. Brain Dis.
PD JUN
PY 2024
VL 39
IS 5
BP 731
EP 739
DI 10.1007/s11011-024-01352-5
EA MAY 2024
PG 9
WC Endocrinology & Metabolism; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology
GA YP3S6
UT WOS:001216055500001
PM 38720093
DA 2025-06-11
ER

PT J
AU Schwarz, R
   Decker, L
   Seeberg, I
   Miskowiak, KW
   Kessing, LV
   Vinberg, M
AF Schwarz, Rasmus
   Decker, Lone
   Seeberg, Ida
   Miskowiak, Kamilla Woznica
   Kessing, Lars Vedel
   Vinberg, Maj
TI Affective disorders: eliminate WArning signs and REstore functioning -
   AWARE - a randomised controlled multimodule intervention study,
   presentation of design and intervention
SO BMJ OPEN
LA English
DT Article
DE Depression & mood disorders; Adult psychiatry; MENTAL HEALTH
ID MAJOR DEPRESSIVE DISORDER; QUALITY-OF-LIFE; BIPOLAR DISORDER;
   RATING-SCALE; INTERNATIONAL CLASSIFICATION; METABOLIC SYNDROME;
   PHYSICAL-ACTIVITY; PROCESS SKILLS; CORE SETS; VALIDATION
AB Introduction Affective disorders are associated with impaired overall functioning and quality of life (QoL). Despite different medical and psychological treatment options, the prognosis remains largely unchanged. Consequently, the field needs new intervention strategies especially targeting patient groups with impaired functioning. This study aims to improve functioning and QoL in patients with affective disorders using a comprehensive 360 degrees intervention.
   Methods and analysis Affective disorders: eliminate WArning signs And REstore (AWARE) functioning is a randomised, controlled, parallel-group design study. Participants will be 120 outpatients, men or women, aged 18-65 years, with a diagnosis of bipolar disorder or major depressive disorder. Inclusion requires an objectively rated impaired functioning defined as a score >= 11 according to the Functioning Assessment Short Test. Participants will be randomised to 6-month AWARE intervention or treatment as usual (TAU). The AWARE intervention is a 360 degrees multimodal intervention based on the International Classification of Functioning Brief Core Set for bipolar and unipolar disorder targeting functioning. The primary outcome is improvement of observation-based activities of daily living (ADL) ability using Assessment of Motor and Process Skills. Secondary outcomes are changes from baseline to endpoint in functioning, QoL, stress, cognition and physical health. Our hypothesis is that the AWARE treatment in comparison with TAU will improve observed ability to perform ADL, patients self-perceived level of functioning and QoL.
   Status: currently recruiting patients.
   Ethics and dissemination Ethical approval has been obtained from The Regional Ethics Committee in the Capital Region of Denmark. All patients will be provided oral and written information about the trial before informed consent is obtained. The study results will be disseminated by peer-review publications. If the present AWARE intervention shows beneficial effects, the goal is to use it as a template for future interventions addressing disability in patients with affective disorders as well as for patients within other diagnostic categories.
C1 [Schwarz, Rasmus] North Zealand Psychiat Ctr, Res Unit, Hillerod, Denmark.
   [Schwarz, Rasmus; Kessing, Lars Vedel; Vinberg, Maj] Univ Copenhagen, Dept Clin Med, Fac Hlth & Med Sci, Copenhagen, Denmark.
   [Decker, Lone] Metropolitan Univ Coll, Dept Physiotherapy & Occupat Therapy, Copenhagen, Denmark.
   [Seeberg, Ida] North Zealand Psychiat Ctr, Dept Dialect Behav Therapy, Hillerod, Denmark.
   [Miskowiak, Kamilla Woznica] Copenhagen Univ Hosp, Neurocognit & Emot Affect Disorder NEAD Grp, Copenhagen Affect Disorder Res Ctr CADIC, Psychiat Ctr Copenhagen, Copenhagen, Denmark.
   [Miskowiak, Kamilla Woznica] Univ Copenhagen, Dept Psychol, Copenhagen, Denmark.
   [Kessing, Lars Vedel] Copenhagen Univ Hosp, Copenhagen Affect Disorder Res Ctr CADIC, Psychiat Ctr Copenhagen, Copenhagen, Denmark.
C3 University of Copenhagen; University of Copenhagen; Copenhagen
   University Hospital; University of Copenhagen; University of Copenhagen;
   Copenhagen University Hospital
RP Schwarz, R (corresponding author), North Zealand Psychiat Ctr, Res Unit, Hillerod, Denmark.; Schwarz, R (corresponding author), Univ Copenhagen, Dept Clin Med, Fac Hlth & Med Sci, Copenhagen, Denmark.
EM rasmus.einar.vagn.schwarz@regionh.dk
RI Kessing, Lars/JNS-2493-2023; Vinberg/ABC-7493-2021
OI Schwarz, Rasmus/0000-0002-8808-1866; Miskowiak,
   Kamilla/0000-0003-2572-1384; Kessing, Lars/0000-0001-9377-9436
FU Capital Region of Denmark [F-61181-03-16]; Occupational Therapists'
   Research Foundation; A.P. Moller Foundation for the Advancement of
   Medical Science; TRYG Foundation; Mental Health Services
FX The study is funded via the Mental Health Services, Capital Region of
   Denmark (grant number F-61181-03-16), the Occupational Therapists'
   Research Foundation (grant number N/A), the A.P. Moller Foundation for
   the Advancement of Medical Science (grant number N/A) and the TRYG
   Foundation (grant number N/A). The initiative for the study was taken by
   doctors and researchers at the Psychiatric Center Copenhagen and at the
   Copenhagen University College who are not affiliated with the donors.
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NR 70
TC 3
Z9 3
U1 0
U2 3
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2044-6055
J9 BMJ OPEN
JI BMJ Open
PD MAY
PY 2022
VL 12
IS 5
AR e058839
DI 10.1136/bmjopen-2021-058839
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 1S6VA
UT WOS:000804185600002
PM 35618335
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Xu, QY
   Anderson, D
   Lurie-Beck, J
AF Xu, Qunyan
   Anderson, Debra
   Lurie-Beck, Janine
TI The relationship between abdominal obesity and depression in the general
   population: A systematic review and meta-analysis
SO OBESITY RESEARCH & CLINICAL PRACTICE
LA English
DT Review
DE Abdominal obesity; Depression; Cross-sectional studies; Meta-analysis
ID BODY-MASS INDEX; METABOLIC SYNDROME; WAIST CIRCUMFERENCE; CARDIOVASCULAR
   RISK; YOUNG-ADULTS; HIP RATIO; SYMPTOMS; ASSOCIATION; DISEASE; HEALTH
AB Obesity has been widely regarded as a public health concern because of its adverse impact on individuals' health. Systematic reviews have been published in examining the effect of obesity on depression, but with major emphasis on general obesity as measured by the body mass index. Despite a stronger effect of abdominal obesity on individuals' physical health outcomes, to our best knowledge, no systematic review was undertaken with regard to the relationship between abdominal obesity and depression. This paper reports the results of a systematic review and meta-analysis of cross-sectional studies examining the relationship between abdominal obesity and depression in a general population. Multiple electronic databases were searched until the end of September 2009. 15 articles were systematically reviewed and meta-analyzed. The analysis showed that the odds ratio of having depression for individuals with abdominal obesity was 1.38 (95% CI, 1.22-1.57) as compared to those who are not obese. Furthermore, it was found that this relationship did not vary with potential confounders including gender, age, measurement of depression and abdominal obesity, and study quality. (C) 2011 Asian Oceanian Association for the Study of Obesity. Published by Elsevier Ltd. All rights reserved.
C1 [Xu, Qunyan; Anderson, Debra] Queensland Univ Technol, Inst Hlth & Biomed Innovat, Brisbane, Qld 4001, Australia.
   [Lurie-Beck, Janine] Queensland Univ Technol, Sch Psychol & Counseling, Fac Hlth, Brisbane, Qld 4001, Australia.
C3 Queensland University of Technology (QUT); Queensland University of
   Technology (QUT)
RP Xu, QY (corresponding author), N Block,QUT Kelvin Grove Campus,Victoria Pk Rd, Kelvin Grove, Qld 4059, Australia.
EM qunyan.xu@student.qut.edu.au
RI Anderson, Debra/I-9637-2012; Xu, Qunyan/F-4193-2013
OI Xu, Qunyan/0000-0002-2486-9814; Anderson, Debra/0000-0001-8996-9624
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NR 67
TC 89
Z9 95
U1 2
U2 32
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1871-403X
EI 1878-0318
J9 OBES RES CLIN PRACT
JI Obes. Res. Clin. Pract.
PD OCT-DEC
PY 2011
VL 5
IS 4
BP E267
EP E278
DI 10.1016/j.orcp.2011.04.007
PG 12
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 981GX
UT WOS:000306956100001
PM 24331129
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Vancampfort, D
   Stubbs, B
   Richards, J
   Ward, PB
   Firth, J
   Schuch, FB
   Rosenbaum, S
AF Vancampfort, Davy
   Stubbs, Brendon
   Richards, Justin
   Ward, Philip B.
   Firth, Joseph
   Schuch, Felipe B.
   Rosenbaum, Simon
TI Physical fitness in people with posttraumatic stress disorder: a
   systematic review
SO DISABILITY AND REHABILITATION
LA English
DT Review
DE Stress; trauma; PTSD; physical activity; exercise; physical fitness
ID METABOLIC SYNDROME; MENTAL-DISORDERS; CHRONIC PAIN; MORTALITY; EXERCISE;
   RISK; PTSD; ANTIPSYCHOTICS; COMORBIDITY; PERFORMANCE
AB Purpose: People with posttraumatic stress disorder (PTSD) have an increased risk of cardiovascular diseases (CVD). Physical fitness is a key modifiable risk factor for CVD and associated mortality. We reviewed the evidence-base regarding physical fitness in people with PTSD.
   Methods: Two independent reviewers searched PubMed, CINAHL, PsycARTICLES, PEDro, and SPORTDiscus from inception until May 2016 using the key words "fitness" OR "exercise" AND "posttraumatic stress disorder" OR "PTSD".
   Results: In total, 5 studies involving 192 (44 female) individuals with PTSD met the inclusion criteria. Lower baseline physical fitness are associated with greater reductions in avoidance and hyperarousal symptoms, as well as with total, physical, and social symptoms of anxiety sensitivity. Rigorous data comparing physical fitness with age-and gender matched general population controls are currently lacking.
   Conclusions: The research field regarding physical fitness in people with PTSD is still in its infancy. Given the established relationships between physical fitness, morbidity and mortality in the general population and the current gaps in the PTSD literature, targets for future research include exploring: (a) whether people with PTSD are at risk of low physical fitness and therefore in need of intensified assessment, treatment and follow-up, (b) the relationships among physical fitness, overall health status, chronic disease risk reduction, disability, and mortality in individuals PTSD, (c) psychometric properties of submaximal physical fitness tests in PTSD, (d) physical fitness changes following physical activity in PTSD, and (e) optimal methods of integrating physical activity programs within current treatment models for PTSD.
C1 [Vancampfort, Davy] Univ Leuven, KU Leuven, Dept Rehabil Sci, Leuven, Belgium.
   [Vancampfort, Davy] Katholieke Univ Leuven, Campus Kortenberg, Kortenberg, Belgium.
   [Vancampfort, Davy] UPC KU Leuven, Univ Leuven, Leuven, Belgium.
   [Stubbs, Brendon] South London & Maudsley NHS Fdn Trust, Physiotherapy Dept, Denmark Hill, London, England.
   [Stubbs, Brendon] Kings Coll London, Inst Psychiat, Hlth Serv, De Crespigny Pk, London, England.
   [Stubbs, Brendon] Kings Coll London, Inst Psychiat, Populat Res Dept, De Crespigny Pk, London, England.
   [Richards, Justin] Univ Sydney, Charles Perkins Ctr, Sch Publ Hlth, Sydney, NSW, Australia.
   [Ward, Philip B.] UNSW Australia, Sch Psychiat, Sydney, NSW, Australia.
   [Ward, Philip B.] Ingham Inst Appl Med Res, Schizophrenia Res Unit, Liverpool, NSW, Australia.
   [Firth, Joseph] Univ Manchester, Inst Brain Behav & Mental Hlth, Manchester, Lancs, England.
   [Schuch, Felipe B.] Hosp Clin Porto Alegre, Porto Alegre, RS, Brazil.
   [Schuch, Felipe B.] Univ Fed Rio Grande do Sul, Programa Pos Grad Ciencias Med Psiquiatria, Porto Alegre, RS, Brazil.
   [Rosenbaum, Simon] UNSW Australia, Sch Med Sci, Dept Exercise Physiol, Sydney, NSW, Australia.
C3 KU Leuven; KU Leuven; KU Leuven; University of London; King's College
   London; University of London; King's College London; University of
   Sydney; University of New South Wales Sydney; Ingham Institute for
   Applied Medical Research; University of Manchester; Hospital de Clinicas
   de Porto Alegre; Universidade Federal do Rio Grande do Sul; University
   of New South Wales Sydney
RP Vancampfort, D (corresponding author), UPC KU Leuven, Campus Kortenberg, B-3070 Kortenberg, Belgium.
EM davy.vancampfort@kuleuven.be
RI Schuch, Felipe/AAF-5028-2019; Firth, Joseph/JOZ-1679-2023; Rosenbaum,
   Simon/Y-3241-2019; Stubbs, Brendon/X-1904-2018; Vancampfort,
   Davy/AAD-1987-2019; Schuch, Felipe/L-4620-2016; Stubbs,
   Brendon/C-5696-2015; Ward, Philip/JCE-6293-2023
OI Schuch, Felipe/0000-0002-5190-4515; Stubbs, Brendon/0000-0001-7387-3791;
   Richards, Justin/0000-0003-4584-8614; Ward, Philip/0000-0002-5779-7722;
   Rosenbaum, Simon/0000-0002-8984-4941
FU Research Foundation Flanders (FWO-Vlaanderen); Society for Mental Health
   Research (SMHR); Applied Health Research and Care South London theme
FX This research received no specific grant from any funding agency in the
   public, commercial, or not-for-profit sectors. Davy Vancampfort has got
   support from the Research Foundation Flanders (FWO-Vlaanderen). Simon
   Rosenbaum is funded by a Society for Mental Health Research (SMHR) Early
   Career Fellowship. Brendon Stubbs was supported by the Collaboration for
   Leadership in Applied Health Research and Care South London theme. No
   sources of funding were used to assist in the preparation of this
   article.
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NR 39
TC 26
Z9 28
U1 1
U2 21
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0963-8288
EI 1464-5165
J9 DISABIL REHABIL
JI Disabil. Rehabil.
PY 2017
VL 39
IS 24
BP 2461
EP 2467
DI 10.1080/09638288.2016.1226412
PG 7
WC Rehabilitation
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Rehabilitation
GA FG7CG
UT WOS:000410565300001
PM 27628485
DA 2025-06-11
ER

PT J
AU Fabianová, K
   Babel'ová, J
   Fabian, D
   Popovicová, A
   Martoncíková, M
   Racek, A
   Raceková, E
AF Fabianova, Kamila
   Babel'ova, Janka
   Fabian, Dusan
   Popovicova, Alexandra
   Martoncikova, Marcela
   Racek, Adam
   Racekova, Eniko
TI Maternal High-Energy Diet during Pregnancy and Lactation Impairs
   Neurogenesis and Alters the Behavior of Adult Offspring in a
   Phenotype-Dependent Manner
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE maternal nutrition; obesity; subventricular zone; rostral migratory
   stream; neurogenesis; high-energy diet; cell proliferation; cell
   degeneration; nitric oxide
ID HIGH-FAT DIET; SUBVENTRICULAR ZONE NEUROGENESIS; ROSTRAL MIGRATORY
   STREAM; HIPPOCAMPAL NEUROGENESIS; INDUCED OBESITY; NITRIC-OXIDE;
   CELL-PROLIFERATION; METABOLIC SYNDROME; COGNITIVE IMPAIRMENT;
   INSULIN-RESISTANCE
AB Obesity is one of the biggest and most costly health challenges the modern world encounters. Substantial evidence suggests that the risk of metabolic syndrome or obesity formation may be affected at a very early stage of development, in particular through fetal and/or neonatal overfeeding. Outcomes from epidemiological studies indicate that maternal nutrition during pregnancy and lactation has a profound impact on adult neurogenesis in the offspring. In the present study, an intergenerational dietary model employing overfeeding of experimental mice during prenatal and early postnatal development was applied to acquire mice with various body conditions. We investigated the impact of the maternal high-energy diet during pregnancy and lactation on adult neurogenesis in the olfactory neurogenic region involving the subventricular zone (SVZ) and the rostral migratory stream (RMS) and some behavioral tasks including memory, anxiety and nociception. Our findings show that a maternal high-energy diet administered during pregnancy and lactation modifies proliferation and differentiation, and induced degeneration of cells in the SVZ/RMS of offspring, but only in mice where extreme phenotype, such as significant overweight/adiposity or obesity is manifested. Thereafter, a maternal high-energy diet enhances anxiety-related behavior in offspring regardless of its body condition and impairs learning and memory in offspring with an extreme phenotype.
C1 [Fabianova, Kamila; Popovicova, Alexandra; Martoncikova, Marcela; Racek, Adam; Racekova, Eniko] Slovak Acad Sci, Biomed Res Ctr, Inst Neurobiol, Soltesovej 4, Kosice 04001, Slovakia.
   [Babel'ova, Janka; Fabian, Dusan] Slovak Acad Sci, Ctr Biosci, Inst Anim Physiol, Soltesovej 4-6, Kosice 04001, Slovakia.
C3 Slovak Academy of Sciences; Institute of Neurobiology, SAS; Slovak
   Academy of Sciences; Institute of Animal Physiology, SAS; Centre of
   Biosciences, SAS
RP Fabianová, K (corresponding author), Slovak Acad Sci, Biomed Res Ctr, Inst Neurobiol, Soltesovej 4, Kosice 04001, Slovakia.
EM fabianova@saske.sk; kubandova@saske.sk; fabian@saske.sk;
   popovicova@saske.sk; martoncikova@saske.sk; racek@saske.sk;
   racekova@saske.sk
RI Babeľová, Janka/GZL-1878-2022; Fabian, Dusan/M-3770-2017; Martoncikova,
   Marcela/F-3622-2018; Fabianova, Kamila/AAR-3211-2021; Racekova,
   Eniko/AGO-9200-2022
OI Babelova, Janka/0000-0002-9606-9795; Fabian, Dusan/0000-0003-3216-2058;
   Martoncikova, Marcela/0000-0001-5418-1693; Fabianova,
   Kamila/0000-0003-2965-4625; Racekova, Eniko/0000-0002-3650-2251
FU European Regional Development Fund [ITMS: 313011V344, ITMS: 313011V455];
    [APVV-19-0279]
FX This research was funded by APVV-19-0279. This publication was created
   thanks to support under the Operational Programme Integrated
   Infrastructure for the projects: Long-term strategic research of
   prevention, intervention and mechanisms of obesity and its
   comorbidities, ITMS: 313011V344 and Open scientific community for modern
   interdisciplinary research in medicine, ITMS: 313011V455, co-financed by
   the European Regional Development Fund.
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NR 150
TC 4
Z9 4
U1 2
U2 13
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD MAY
PY 2022
VL 23
IS 10
AR 5564
DI 10.3390/ijms23105564
PG 25
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 1Q1OO
UT WOS:000802466200001
PM 35628378
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Naqvi, HA
   Wang, D
   Glozier, N
   Grunstein, RR
AF Naqvi, Haider A.
   Wang, David
   Glozier, Nicholas
   Grunstein, Ronald R.
TI Sleep-Disordered Breathing and Psychiatric Disorders
SO CURRENT PSYCHIATRY REPORTS
LA English
DT Article
DE Sleep apnoea; Depression; Schizophrenia; Bipolar disorder; Substance
   abuse; CPAP
ID POSITIVE AIRWAY PRESSURE; QUALITY-OF-LIFE; DAYTIME SLEEPINESS;
   DEPRESSIVE SYMPTOMS; BIPOLAR DISORDER; ORAL APPLIANCE; METABOLIC
   SYNDROME; MAJOR DEPRESSION; APNEA-HYPOPNEA; CPAP TREATMENT
AB Sleep-disordered breathing, the commonest form of which is obstructive sleep apnoea (OSA) is increasingly recognised as a treatable cause of morbidity. It shares many risk factors with psychiatric disorders including behaviours such as smoking and physical comorbidity. Many symptoms of the two overlap, leaving OSA often undetected and undertreated. In the few studies that assess the two, OSA is commonly comorbid with depression (17-45 %) and schizophrenia (up to 55 %) and possibly bipolar. There is some limited evidence that treating OSA can ameliorate psychiatric symptoms. Some psychotropics, such as narcotics, cause sleep-disordered breathing (SDB), whilst weight-inducing neuroleptics may exacerbate it. An extreme form of SDB, sudden infant death syndrome (SIDS), is a risk in mothers with substance abuse. Being aware of these common comorbidities may help improve psychiatric patient's treatment and quality of life.
C1 [Naqvi, Haider A.; Wang, David; Grunstein, Ronald R.] Woolcock Inst Med Res, Sleep & Circadian Grp, Sydney, NSW 2037, Australia.
   [Wang, David; Grunstein, Ronald R.] Royal Prince Alfred Hosp, Dept Resp & Sleep Med, Camperdown, NSW 2050, Australia.
   [Wang, David; Glozier, Nicholas; Grunstein, Ronald R.] Univ Sydney, Ctr Integrated Res & Understanding Sleep CIRUS, Sydney, NSW 2006, Australia.
   [Glozier, Nicholas] Univ Sydney, Discipline Psychiat, Brain & Mind Res Inst, Sydney, NSW 2006, Australia.
C3 University of Sydney; Woolcock Institute of Medical Research; NSW
   Health; Royal Prince Alfred Hospital; University of Sydney; University
   of Sydney; University of Sydney
RP Naqvi, HA (corresponding author), Woolcock Inst Med Res, Sleep & Circadian Grp, 431 Glebe Point Rd Glebe, Sydney, NSW 2037, Australia.
EM haider.naqvi93@yahoo.com
RI Glozier, Nick/A-7440-2011
OI Glozier, Nick/0000-0002-0476-9146; Grunstein,
   Ronald/0000-0001-6682-5812; Wang, David/0000-0002-3975-6214
FU NHMRC (Centre of Research Excellence-Neurosleep)
FX Nicholas Glozier has received a grant from the NHMRC (Centre of Research
   Excellence-Neurosleep).
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NR 97
TC 22
Z9 26
U1 1
U2 35
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1523-3812
EI 1535-1645
J9 CURR PSYCHIAT REP
JI Curr. Psychiatry Rep.
PD DEC
PY 2014
VL 16
IS 12
AR 519
DI 10.1007/s11920-014-0519-z
PG 11
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA AR9KX
UT WOS:000343893600006
PM 25308389
DA 2025-06-11
ER

PT J
AU Hsu, NW
   Chou, KC
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AF Hsu, Nai-Wei
   Chou, Kai-Chen
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   Hung, Chung-Lieh
   Kuo, Chien-Feng
   Tsai, Shin-Yi
TI Building a model for predicting metabolic syndrome using artificial
   intelligence based on an investigation of whole-genome sequencing
SO JOURNAL OF TRANSLATIONAL MEDICINE
LA English
DT Article
DE Circadian rhythm; Metabolic syndrome; Whole-genome sequencing; Deep
   learning
ID CIRCADIAN-RHYTHMS; OXIDATIVE STRESS; POPULATION; GENES; SLEEP; RISK;
   RORA
AB Background The circadian system is responsible for regulating various physiological activities and behaviors and has been gaining recognition. The circadian rhythm is adjusted in a 24-h cycle and has transcriptional-translational feedback loops. When the circadian rhythm is interrupted, affecting the expression of circadian genes, the phenotypes of diseases could amplify. For example, the importance of maintaining the internal temporal homeostasis conferred by the circadian system is revealed as mutations in genes coding for core components of the clock result in diseases. This study will investigate the association between circadian genes and metabolic syndromes in a Taiwanese population. Methods We performed analysis using whole-genome sequencing, read vcf files and set target circadian genes to determine if there were variants on target genes. In this study, we have investigated genetic contribution of circadian-related diseases using population-based next generation whole genome sequencing. We also used significant SNPs to create a metabolic syndrome prediction model. Logistic regression, random forest, adaboost, and neural network were used to predict metabolic syndrome. In addition, we used random forest model variables importance matrix to select 40 more significant SNPs, which were subsequently incorporated to create new prediction models and to compare with previous models. The data was then utilized for training set and testing set using five-fold cross validation. Each model was evaluated with the following criteria: area under the receiver operating characteristics curve (AUC), precision, F1 score, and average precision (the area under the precision recall curve). Results After searching significant variants, we used Chi-Square tests to find some variants. We found 186 significant SNPs, and four predicting models which used 186 SNPs (logistic regression, random forest, adaboost and neural network), AUC were 0.68, 0.8, 0.82, 0.81 respectively. The F1 scores were 0.412, 0.078, 0.295, 0.552, respectively. The other three models which used the 40 SNPs (logistic regression, adaboost and neural network), AUC were 0.82, 0.81, 0.81 respectively. The F1 scores were 0.584, 0.395, 0.574, respectively. Conclusions Circadian gene defect may also contribute to metabolic syndrome. Our study found several related genes and building a simple model to predict metabolic syndrome.
C1 [Hsu, Nai-Wei; Hung, Chung-Lieh; Kuo, Chien-Feng; Tsai, Shin-Yi] Mackay Med Coll, Dept Med, New Taipei, Taiwan.
   [Chou, Kai-Chen; Wang, Yu-Ting Tina; Tsai, Shin-Yi] MacKay Mem Hosp, Dept Lab Med, Taipei, Taiwan.
   [Kuo, Chien-Feng] MacKay Jr Coll Med Nursing & Management, Dept Nursing, New Taipei, Taiwan.
   [Kuo, Chien-Feng] Mackay Mem Hosp, Dept Internal Med, Div Infect Dis, Taipei, Taiwan.
   [Tsai, Shin-Yi] Johns Hopkins Univ, Johns Hopkins Bloomberg Sch Publ Hlth, Dept Hlth Policy & Management, Baltimore, MD 21205 USA.
   [Hung, Chung-Lieh; Tsai, Shin-Yi] Mackay Med Coll, Inst Biomed Sci, New Taipei, Taiwan.
   [Tsai, Shin-Yi] Mackay Med Coll, Inst Long Term Care, New Taipei, Taiwan.
C3 Mackay Medical College; Mackay Memorial Hospital; Mackay Junior College
   of Medicine, Nursing & Management; Mackay Memorial Hospital; Johns
   Hopkins University; Johns Hopkins Bloomberg School of Public Health;
   Mackay Medical College; Mackay Medical College
RP Tsai, SY (corresponding author), Mackay Med Coll, Dept Med, New Taipei, Taiwan.; Tsai, SY (corresponding author), MacKay Mem Hosp, Dept Lab Med, Taipei, Taiwan.; Tsai, SY (corresponding author), Johns Hopkins Univ, Johns Hopkins Bloomberg Sch Publ Hlth, Dept Hlth Policy & Management, Baltimore, MD 21205 USA.; Tsai, SY (corresponding author), Mackay Med Coll, Inst Biomed Sci, New Taipei, Taiwan.; Tsai, SY (corresponding author), Mackay Med Coll, Inst Long Term Care, New Taipei, Taiwan.
EM stsai22@jhu.edu
RI huang, wenyu/HTQ-5747-2023; Tsai, Shin-Yi/AAQ-7649-2020
OI Tsai, Shin-Yi/0000-0001-7978-778X
FU Department of Medical Research at Mackay Memorial Hospital, Taiwan
   [MMH-106-81, MMH-107-71, MMH107-102, MMH-107-135, MMH-109-79,
   MMH-109-103]; Mackay Medical College [1082A03]; Department of Medical
   Research at Mackay Memorial Hospital
FX This study was supported by the Department of Medical Research at Mackay
   Memorial Hospital, Taiwan, Grant Numbers MMH-106-81, MMH-107-71,
   MMH107-102, MMH-107-135, MMH-109-79, MMH-109-103, and Mackay Medical
   College, Grant Number 1082A03. The APC was funded by the Department of
   Medical Research at Mackay Memorial Hospital and both of the co-first
   and the corresponding author: Dr. Chien-Feng Kuo and Dr. Shin-Yi Tsai.
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NR 54
TC 12
Z9 12
U1 0
U2 7
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1479-5876
J9 J TRANSL MED
JI J. Transl. Med.
PD APR 28
PY 2022
VL 20
IS 1
AR 190
DI 10.1186/s12967-022-03379-7
PG 12
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 0V8LR
UT WOS:000788592100003
PM 35484552
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Geurts, L
   Everard, A
   le Ruyet, P
   Delzenne, NM
   Cani, PD
AF Geurts, Lucie
   Everard, Amandine
   le Ruyet, Pascale
   Delzenne, Nathalie M.
   Cani, Patrice D.
TI Ripened Dairy Products Differentially Affect Hepatic Lipid Content and
   Adipose Tissue Oxidative Stress Markers in Obese and Type 2 Diabetic
   Mice
SO JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
LA English
DT Article
DE glucose tolerance; hepatic steatosis; type 2 diabetes; cheese; oxidative
   stress
ID HIGH-FAT DIET; INSULIN-RESISTANCE SYNDROME; GUT MICROBIOTA; SOYBEAN
   LECITHIN; INFLAMMATION; CONSUMPTION; STEATOSIS; HYPERGLYCEMIA;
   PATHOGENESIS; METABOLISM
AB Growing evidence suggests that the consumption of dairy products may contribute to a reduced incidence of cardiovascular risk factors, such as obesity, dyslipidemia, and type 2 diabetes. The fatty acid composition in milk fat, the duration of ripening, and the complexity of the food matrices are important factors that may interfere with the physiological impact. In this study, we treated genetic obese and type 2 diabetic mice (db/db) for 4 weeks with different dairy (cheese-based) products, differing by the duration of ripening (0, 15, or 35 days). We found that 35 days ripened product significantly improved glucose tolerance, an effect associated with a decreased adipose tissue lipid peroxide markers (TBARS and NAPDH-oxidase mRNA expression), without affecting body weight, food intake, and fat mass. Both fermented matrices significantly decreased the hepatic lipid content, without modifying plasma triglycerides or plasma total cholesterol. These data suggest that dairy products issued from longer ripening positively impact glucose tolerance, hepatic steatosis, and adipose tissue oxidative stress. Further investigations are warranted to decipher the interactions between milk products fermentation, lipids, and host metabolism.
C1 [Geurts, Lucie; Everard, Amandine; Delzenne, Nathalie M.; Cani, Patrice D.] Catholic Univ Louvain, Louvain Drug Res Inst, Metab & Nutr Res Grp, B-1200 Brussels, Belgium.
   [le Ruyet, Pascale] Lactalis, RetD Lactalis, Laval, France.
C3 Universite Catholique Louvain
RP Cani, PD (corresponding author), Catholic Univ Louvain, Louvain Drug Res Inst, Metab & Nutr Res Grp, Av E Mounier 73,Box B1-73-11, B-1200 Brussels, Belgium.
EM patrice.cani@uclouvain.be
RI Delzenne, Nathalie/AAC-4628-2019; Cani, Patrice D./M-8055-2016
OI Cani, Patrice D./0000-0003-2040-2448; Delzenne,
   Nathalie/0000-0003-2115-6082; Everard, Amandine/0000-0001-8925-8144
FU FSR; FRSM; Lactalis
FX N.M.D. and P.D.C. are recipients of FSR and FRSM grants (Fonds speciaux
   de recherches, UCL, Belgium; Fonds de la recherche scientifique
   medicale, Belgium).The authors declare the following competing financial
   interest(s): This study was supported in part by Lactalis.
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NR 36
TC 24
Z9 26
U1 0
U2 16
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0021-8561
EI 1520-5118
J9 J AGR FOOD CHEM
JI J. Agric. Food Chem.
PD FEB 29
PY 2012
VL 60
IS 8
BP 2063
EP 2068
DI 10.1021/jf204916x
PG 6
WC Agriculture, Multidisciplinary; Chemistry, Applied; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture; Chemistry; Food Science & Technology
GA 899ZI
UT WOS:000300854900022
PM 22300436
DA 2025-06-11
ER

PT J
AU Sha, H
   Zeng, HR
   Zhao, J
   Jin, HY
AF Sha, Han
   Zeng, Huirong
   Zhao, Jie
   Jin, Haiying
TI Mangiferin ameliorates gestational diabetes mellitus-induced placental
   oxidative stress, inflammation and endoplasmic reticulum stress and
   improves fetal outcomes in mice
SO EUROPEAN JOURNAL OF PHARMACOLOGY
LA English
DT Article
DE Mangiferin; Gestational diabetes mellitus; Oxidative stress;
   Inflammation; Endoplasmic reticulum stress
ID BETA-CELL FUNCTION; INSULIN-RESISTANCE; METABOLIC SYNDROME; MODEL;
   PREGNANCY; GLUCOSE
AB Gestational diabetes mellitus (GDM) is a temporary form of diabetes during pregnancy, which causes maternal diabetic symptoms and abnormal fetal development, and influence the health of maternal-child in clinical practice. Mangiferin is a bioactive ingredient with anti-inflammation, anti-oxidation and anti-endoplasmic reticulum stress activities. In current study, the effects of mangiferin on GDM were evaluated. We reported that mangiferin greatly improved altered glucose and lipid profile, insulin tolerance, and reproductive outcomes of the GDM mice. Mangiferin ameliorated placental oxidative stress, inflammation and ER stress in GDM mice. Therefore, we demonstrated that mangiferin displayed protective effects on gestational diabetes mellitus symptoms by suppressing placental oxidative stress, inflammation and endoplasmic reticulum stress in GDM mice.
C1 [Sha, Han; Zeng, Huirong; Zhao, Jie; Jin, Haiying] Heze Municipal Hosp, Dept Obstet & Gynecol, 2888 Caozhou Rd, Heze 274000, Shandong, Peoples R China.
RP Jin, HY (corresponding author), Heze Municipal Hosp, Dept Obstet & Gynecol, 2888 Caozhou Rd, Heze 274000, Shandong, Peoples R China.
EM jinhaiying2020@163.com
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NR 32
TC 34
Z9 38
U1 1
U2 48
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0014-2999
EI 1879-0712
J9 EUR J PHARMACOL
JI Eur. J. Pharmacol.
PD SEP 15
PY 2019
VL 859
AR 172522
DI 10.1016/j.ejphar.2019.172522
PG 7
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA IM2JT
UT WOS:000477819500015
PM 31276667
DA 2025-06-11
ER

PT J
AU Nunes, SOV
   de Melo, LGP
   de Castro, MRP
   Barbosa, DS
   Vargas, HO
   Berk, M
   Maes, M
AF Vargas Nunes, Sandra Odebrecht
   Piccoli de Melo, Luiz Gustavo
   Pizzo de Castro, Marcia Regina
   Barbosa, Decio Sabbatini
   Vargas, Heber Odebrecht
   Berk, Michael
   Maes, Michael
TI Atherogenic index of plasma and atherogenic coefficient are increased in
   major depression and bipolar disorder, especially when comorbid with
   tobacco use disorder
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Depression; Cardiovascular disease; Tobacco use disorder; Metabolic
   syndrome; Castelli risk index
ID CORONARY-HEART-DISEASE; DENSITY-LIPOPROTEIN CHOLESTEROL;
   CARDIOVASCULAR-DISEASE; INFLAMMATORY MARKERS; SMOKING-CESSATION;
   OXIDATIVE STRESS; HEALTH BEHAVIORS; RISK; SEX; OUTPATIENTS
AB Background: There is a robust comorbidify between mood cl sorclers and cardiovascular disorder (CVD). The atherogenic index of plasma (ALP) and the atherogenic coefficient (AC) are important atherogenic indexes. The aims of this study were to delineate whether AIP and AC are increased in mood disorders especially when comorbid with tobacco use disorder (TUD).
   Methods: In this case control study we included 134 patients with mood disorders, bipolar disorder and unipolar depression (cases), and 197 individuals without mood disorder (controls) divided into those with and without TUD (defined as never smokers), Total cholesterol (TC), triglycerides (TG), high density lipoprotein cholesterol (HDLc) and low density lipoprotein cholesterol (LDLc) were measured. RIP and AC were computed as log (TG/HDLc) and non-HDLc/HDLc, respectively.
   Results: The AIP and AC indexes were significantly increased in patients with mood disorders versus conirols, both in depression and bipolar disorder. PaLienis with mood disorder wiLhoui TUD and paLienis with TUD without mood disorder showed higher ALP and AC values than never smokers while those with comorbid mood disorders and TUD showed significanily higher ALP and AC levels Lhan all other individuals. A large parL of the variance in Lhe AlC (26.4%) and AC (204%) was explained by mood disorders, TUD, male gender and body mass index.
   Conclusions: The findings suggest that lipid abnormalifics leading Lo an increased aiherogenic poLenLial are involved in the pathophysiology of mood disorders (depression and bipolar disorder) and especially comorbid mood disorder and TUD. The comorbidity between mood disorders and CVD may be partly explained increased through AIP and AC indexes, impacting increments in atherogenic potential. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Vargas Nunes, Sandra Odebrecht; Vargas, Heber Odebrecht] Univ Estadual Londrina, Univ Hosp, Hlth Sci Ctr, Dept Clin Med,Psychiat Unit, Londrina, Brazil.
   [Vargas Nunes, Sandra Odebrecht; Piccoli de Melo, Luiz Gustavo; Pizzo de Castro, Marcia Regina; Vargas, Heber Odebrecht] Univ Estadual Londrina, Univ Hosp, Ctr Approach & Treatment Smokers, Londrina, Brazil.
   [Barbosa, Decio Sabbatini] Univ Estadual Londrina, Dept Clin Anal & Toxicol, Londrina, Parana, Brazil.
   [Berk, Michael; Maes, Michael] Deakin Univ, Impact Strateg Res Ctr, Geelong, Vic 3217, Australia.
   [Berk, Michael] Florey Inst Neurosci & Mental Hlth, Orygen Youth Hlth Res Ctr, Parkville, Vic 3052, Australia.
   [Berk, Michael] Florey Inst Neurosci & Mental Hlth, Ctr Youth Mental Hlth, Parkville, Vic 3052, Australia.
   [Berk, Michael] Univ Melbourne, Dept Psychiat, Parkville, Vic 3052, Australia.
   [Vargas Nunes, Sandra Odebrecht; Piccoli de Melo, Luiz Gustavo; Pizzo de Castro, Marcia Regina; Barbosa, Decio Sabbatini; Vargas, Heber Odebrecht; Maes, Michael] Chulalongkorn Univ, Fac Med, Dept Psychiat, Bangkok 10330, Thailand.
   [Maes, Michael] Univ Estadual Londrina, Hlth Sci Ctr, Hlth Sci Grad Program, Londrina, Brazil.
C3 Universidade Estadual de Londrina; Universidade Estadual de Londrina;
   Universidade Estadual de Londrina; Deakin University; Florey Institute
   of Neuroscience & Mental Health; Orygen, The National Centre of
   Excellence in Youth Mental Health; Florey Institute of Neuroscience &
   Mental Health; Orygen, The National Centre of Excellence in Youth Mental
   Health; University of Melbourne; Chulalongkorn University; Universidade
   Estadual de Londrina
RP Maes, M (corresponding author), Chulalongkorn Univ, Fac Med, Dept Psychiat, Bangkok 10330, Thailand.
EM dr.michaelmaes@hotmail.com
RI Berk, Michael/AGH-9427-2022; de Melo, Luiz Gustavo Piccoli/C-2271-2018;
   Nunes, Sandra/B-4035-2019; Maes, Michael/B-8546-2011; Barbosa,
   Décio/AAE-6351-2019; Berk, Michael/M-7891-2013
OI Melo, Luiz Gustavo Piccoli de/0000-0002-1078-8044; Berk,
   Michael/0000-0002-5554-6946; Odebrecht Vargas Nunes,
   Sandra/0000-0003-4851-6121
FU Health Sciences Postgraduate Program [40002012046P0]; Ministry for
   Sciences and Technology of Brazil (CNPq) [404377/2013-3]; Brazilian
   Federal Agency for Support and Evaluation of Graduate Education (CAPES);
   NHMRC [1059660]; CNPq (Consent Nacional de Desenvolvimento Cientifico e
   Technologia)
FX This study is supported by the Health Sciences Postgraduate Program
   (Grant no 40002012046P0) at the State University of Londrina, Brazil;
   the Ministry for Sciences and Technology of Brazil (CNPq (Grant no
   404377/2013-3)), the Brazilian Federal Agency for Support and Evaluation
   of Graduate Education (CAPES).MB is supported by a NHMRC Senior
   Principal Research Fellowship 1059660.MM is supported by a CNPq (Consent
   Nacional de Desenvolvimento Cientifico e Technologia) PVE fellowship and
   the Health Sciences Graduate Program fellowship, Londrina State
   University (UEL).
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NR 51
TC 72
Z9 74
U1 1
U2 15
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD FEB 1
PY 2015
VL 172
BP 55
EP 62
DI 10.1016/j.jad.2014.09.038
PG 8
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA AX0LD
UT WOS:000346643000009
PM 25451396
DA 2025-06-11
ER

PT J
AU Smith, SR
   Bai, FL
   Charbonneau, C
   Janderová, L
   Argyropoulos, G
AF Smith, SR
   Bai, FL
   Charbonneau, C
   Janderová, L
   Argyropoulos, G
TI A promoter genotype and oxidative stress potentially link resistin to
   human insulin resistance
SO DIABETES
LA English
DT Article
ID ADIPOSE-TISSUE; ADIPOCYTE DIFFERENTIATION; 3T3-L1 ADIPOCYTES;
   GLUCOSE-TRANSPORT; OBESITY; EXPRESSION; GENE; FAT; ASSOCIATION;
   CAUCASIANS
AB Insulin resistance is a component of type 2 diabetes and often precedes pancreatic beta-cell failure. Contributing factors include obesity and a central pattern of fat accumulation with a strong genetic component. The adipocyte secreted hormone resistin has been proposed as a link between the adipocyte and insulin resistance by inhibition of insulin-stimulated glucose uptake and/or blocking adipocyte differentiation. Here we report that the G/G genotype of a single nucleotide polymorphism (SNP) in the promoter of the human resistin gene, -180C>G, had significantly increased basal promoter activity in adipocytes. These data were recapitulated in vivo, where G/G homozygotes had significantly higher resistin mRNA levels in human abdominal subcutaneous fat. A significant interaction was also found between the -180C>G SNP, a marker of oxidative stress (NAD[P]H quinone oxidoreductase mRNA) and homeostasis model assessment of insulin resistance. In addition, resistin mRNA was positively and independently correlated with insulin resistance and hepatic fat as measured by liver X-ray attenuation. These data implicate resistin in the pathophysiology of the human insulin resistance syndrome, an effect mediated by the -180C>G promoter SNP and potentially cellular oxidative stress.
C1 Pennington Biomed Res Ctr, Baton Rouge, LA 70808 USA.
C3 Louisiana State University System; Louisiana State University;
   Pennington Biomedical Research Center
RP Pennington Biomed Res Ctr, 6400 Perkins Rd, Baton Rouge, LA 70808 USA.
EM smithsr@pbrc.edu; argyrog@pbre.edu
RI ; Rossmeislova, Lenka/D-1931-2013
OI Smith, Steven/0000-0002-5098-8147; Rossmeislova,
   Lenka/0000-0002-7611-7585
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NR 41
TC 148
Z9 160
U1 0
U2 7
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0012-1797
EI 1939-327X
J9 DIABETES
JI Diabetes
PD JUL
PY 2003
VL 52
IS 7
BP 1611
EP 1618
DI 10.2337/diabetes.52.7.1611
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 695PF
UT WOS:000183838900004
PM 12829623
OA hybrid
DA 2025-06-11
ER

PT J
AU Parente, DJ
   Garriga, C
   Baskin, B
   Douglas, G
   Cho, MT
   Araujo, GC
   Shinawi, M
AF Parente, Daniel J.
   Garriga, Caryn
   Baskin, Berivan
   Douglas, Ganka
   Cho, Megan T.
   Araujo, Gabriel C.
   Shinawi, Marwan
TI Neuroligin 2 Nonsense Variant Associated with Anxiety, Autism,
   Intellectual Disability, Hyperphagia, and Obesity
SO AMERICAN JOURNAL OF MEDICAL GENETICS PART A
LA English
DT Article
DE NLGN2; anxiety; autism; obesity; synaptic function
ID GENE-EXPRESSION; MICE LACKING; SYNAPSE; SCHIZOPHRENIA; MUTATIONS;
   SYSTEMS
AB Neuroligins are post-synaptic, cellular adhesion molecules implicated in synaptic formation and function. NLGN2 is strongly linked to inhibitory, GABAergic signaling and is crucial for maintaining the excitation-inhibition balance in the brain. Disruption of the excitation-inhibition balance is associated with neuropsychiatric disease. In animal models, altered NLGN2 expression causes anxiety, developmental delay, motor discoordination, social impairment, aggression, and sensory processing defects. In humans, mutations in NLGN3 and NLGN4 are linked to autism and schizophrenia; NLGN2 missense variants are implicated in schizophrenia. Copy number variants encompassing NLGN2 on 17p13.1 are associated with autism, intellectual disability, metabolic syndrome, diabetes, and dysmorphic features, but an isolated NLGN2 nonsense variant has not yet been described in humans. Here, we describe a 15-year-old male with severe anxiety, obsessive-compulsive behaviors, developmental delay, autism, obesity, macrocephaly, and some dysmorphic features. Exome sequencing identified a heterozygous, de novo, c.441C>A p.(Tyr147Ter) variant in NLGN2 that is predicted to cause loss of normal protein function. This is the first report of an NLGN2 nonsense variant in humans, adding to the accumulating evidence that links synaptic proteins with a spectrum of neurodevelopmental phenotypes. (C) 2016 Wiley Periodicals, Inc.
C1 [Parente, Daniel J.] Univ Kansas, Med Ctr, Dept Family Med, Kansas City, KS 66103 USA.
   [Garriga, Caryn] St Louis Childrens Hosp, St Louis, MO 63178 USA.
   [Baskin, Berivan; Douglas, Ganka; Cho, Megan T.] GeneDx, Gaithersburg, MD USA.
   [Araujo, Gabriel C.] St Louis Childrens Hosp, Dept Psychol, St Louis, MO 63178 USA.
   [Shinawi, Marwan] Washington Univ, Sch Med, Dept Pediat, Div Genet & Genom Med, One Childrens Pl,Northwest Tower,9132, St Louis, MO 63110 USA.
C3 University of Kansas; University of Kansas Medical Center; Washington
   University (WUSTL); St. Louis Children's Hospital; Washington University
   (WUSTL); St. Louis Children's Hospital; Washington University (WUSTL)
RP Shinawi, M (corresponding author), Washington Univ, Sch Med, Dept Pediat, Div Genet & Genom Med, One Childrens Pl,Northwest Tower,9132, St Louis, MO 63110 USA.
EM shinawi_m@kids.wustl.edu
RI Parente, Daniel/AAM-3887-2021
OI shinawi, Marwan/0000-0003-1329-4100
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NR 21
TC 66
Z9 76
U1 1
U2 9
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1552-4825
EI 1552-4833
J9 AM J MED GENET A
JI Am. J. Med. Genet. A
PD JAN
PY 2017
VL 173
IS 1
BP 213
EP 216
DI 10.1002/ajmg.a.37977
PG 4
WC Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Genetics & Heredity
GA EJ3TM
UT WOS:000393134900031
PM 27865048
DA 2025-06-11
ER

PT J
AU Park, HE
   Song, HY
   Han, K
   Cho, KH
   Kim, YH
AF Park, Hyo-Eun
   Song, Hye Young
   Han, Kyungdo
   Cho, Kyung-Hwan
   Kim, Yang-Hyun
TI Number of remaining teeth and health-related quality of life: the Korean
   National Health and Nutrition Examination Survey 2010-2012
SO HEALTH AND QUALITY OF LIFE OUTCOMES
LA English
DT Article
DE Remaining teeth; Quality of life; EQ-5D; Korean National Health and
   nutrition examination survey
ID ORAL-HEALTH; GENERAL HEALTH; COMPLETE DENTURES; IMPACT; MULTIATTRIBUTE;
   ASSOCIATION; MODEL; AGE
AB Objectives/aimsWith the Euro-Qol-5 dimension (EQ-5D) system, we investigated the relationship between the number of remaining teeth and QoL using data from the Korean National Health and Nutrition Examination Survey (KNHANES), 2010-2012. A total of 17,417 participants, more than 19years old, were finally included in this study (men=7394 and women=10,023). Through this study, we have discovered that the remaining teeth affect overall health and that the fewer number of them may indicate a lower quality of life, as well.The quality of life according to the number of remaining teeth was assessed among Koreans using the Euro-Qol-5 dimension (EQ-5D) system.MethodThe Euro-Qol-5 dimension (EQ-5D) system was used to measure the health-related QoL. Its five dimensions included mobility, self-care, usual activities, pain/discomfort, and anxiety/depression. The respondents were asked to choose one of the followings: G 1, no problems; G 2, some problems; and G 3, problematic, to best describe their health status for the five dimensions. Then, we assigned low QoL to G2+G3 and high QoL to G1.We used age, gender, economic income, educational level, residence, and marital status for the demographic variables and, drinking, smoking, exercise, BMI, and metabolic syndrome for health behaviors. Multiple logistic regression analysis was performed to examine the odds ratios (ORs) and confidence intervals (CIs) for the high QoL (G1) on the five categories of EQ-5D according to the number of remaining teeth. On the basis of the 0-15 remaining teeth group, we drew a comparison of the QoL between the 16-20 and 21-28 remaining teeth groups.ResultsSubjects with 21-28 remaining teeth had higher QoL scores and had higher ORs of high QoL, especially for mobility (OR=1.256, 95% CI=1.056-1.495), self-care (OR=1.441, 95% CI=1.096-1.894), and usual activities (OR=1.241, 95% CI=1.022-1.508, respectively), than those with 0-15 remaining teeth after adjusting for age, sex, body mass index, smoking, drinking, exercise, income, education, and metabolic syndrome.ORs from the high QoL had the tendency to increase as the number of remaining teeth increased (all p for trend <0.05). However, there was no relationship between the number of remaining teeth and QoL in the pain/discomfort and anxiety/depression dimensions.ConclusionThe number of remaining teeth was associated with QoL, and subjects who had more teeth obtained higher QoL scores. The subjects in the high QoL group were especially associated with the components of EQ-5D such as mobility, self-care, and daily living.
C1 [Park, Hyo-Eun] Korea Univ, Coll Nursing, Grad Sch Nursing, Seoul, South Korea.
   [Park, Hyo-Eun] Suwon Womens Univ, Dept Nursing, 72 Onjeong Ro, Suwon, Gyeonggi, South Korea.
   [Song, Hye Young] Ewha Womans Univ Korea, Grad Sch Nursing, Seoul, South Korea.
   [Han, Kyungdo] Catholic Univ, Coll Med, Dept Med Stat, Seoul, South Korea.
   [Cho, Kyung-Hwan; Kim, Yang-Hyun] Korea Univ, Anam Hosp, Coll Med, Dept Family Med, 73 Inchon Ro, Seoul 02841, South Korea.
C3 Korea University; Ewha Womans University; Catholic University of Korea;
   Korea University; Korea University Medicine (KU Medicine)
RP Kim, YH (corresponding author), Korea Univ, Anam Hosp, Coll Med, Dept Family Med, 73 Inchon Ro, Seoul 02841, South Korea.
EM lisa0713@swc.ac.kr; mrchir@naver.com
RI Han, Kyungdo/JKH-7628-2023; Kim, Jinkwon/AAR-6729-2021
OI Kim, Yang-Hyun/0000-0003-3548-8758
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NR 59
TC 28
Z9 29
U1 2
U2 7
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1477-7525
J9 HEALTH QUAL LIFE OUT
JI Health Qual. Life Outcomes
PD JAN 9
PY 2019
VL 17
AR 5
DI 10.1186/s12955-019-1078-0
PG 10
WC Health Care Sciences & Services; Health Policy & Services
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services
GA HH0EW
UT WOS:000455387400001
PM 30626402
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Giltay, EJ
   Tishova, YA
   Mskhalaya, GJ
   Gooren, LJG
   Saad, F
   Kalinchenko, SY
AF Giltay, Erik J.
   Tishova, Yuliya A.
   Mskhalaya, George J.
   Gooren, Louis J. G.
   Saad, Farid
   Kalinchenko, Svetlana Y.
TI Effects of Testosterone Supplementation on Depressive Symptoms and
   Sexual Dysfunction in Hypogonadal Men with the Metabolic Syndrome
SO JOURNAL OF SEXUAL MEDICINE
LA English
DT Article
DE Randomized Trial; Testosterone Administration; Metabolic Syndrome;
   Depression; Placebo-controlled; Sexual Dysfunction
ID QUALITY-OF-LIFE; LATE-ONSET HYPOGONADISM; OLDER MEN; DOUBLE-BLIND;
   REPLACEMENT THERAPY; TRANSDERMAL DIHYDROTESTOSTERONE; BIOAVAILABLE
   TESTOSTERONE; ERECTILE DYSFUNCTION; INTERNATIONAL INDEX; ANDROGEN
   DEFICIENCY
AB Introduction.
   Low testosterone levels in men are associated with the metabolic syndrome (MetS) as well as with depressive symptoms, low vitality, and sexual dysfunction.
   Aim.
   To assess the effects of testosterone administration on these subjective symptoms, which have not extensively been studied in hypogonadal men with the MetS.
   Main Outcome Measures.
   The Beck Depression Inventory (BDI-IA), Aging Males' Symptoms (AMS) scale, and International Index of Erectile Function 5-item (IIEF-5) scale at baseline, 18 and 30 weeks were analysed using multilevel analysis.
   Methods.
   In a randomized, placebo-controlled, double-blind, phase III trial (ClinicalTrials.gov identifier: NCT00696748), 184 men suffering from both the MetS and hypogonadism were included. They were treated for 30 weeks with either parenteral testosterone undecanoate (TU; 1,000 mg IM TU, at baseline, and after 6 and 18 weeks; Nebido (R)) or placebo injections, 105 (92.9%) men receiving TU and 65 (91.5%) receiving placebo completed the 30-week trial.
   Results.
   The 184 men were aged mean 52.1 years old (standard deviation [SD] 9.6; range 35-69), with a mean body mass index of 35.5 kg/m2 (SD 6.7; range 25.1-54.8), and a mean total testosterone level of 8.0 nmol/L (SD 4.0). There were significant improvements in BDI-IA (mean difference vs. placebo after 30 weeks: -2.5 points; 95% confidence interval [CI]: -0.9; -4.1; P = 0.003), AMS (-7.4 points; 95% CI: -4.3; -10.5; P < 0.001), and IIEF-5 (+3.1 points; 95% CI: +1.8; +4.4; P < 0.001). The effects on the BDI-IA, AMS, and IIEF-5 were strongest in men with baseline total testosterone levels < 7.7 mmol/L (i.e., median value).
   Conclusions.
   TU administration may improve depressive symptoms, aging male symptoms and sexual dysfunction in hypogonadal men with the MetS. The beneficial effects of testosterone were most evident in men with the lowest baseline total testosterone levels. Giltay EJ, Tishova YA, Mskhalaya GJ, Gooren LJG, Saad F, and Kalinchenko SY. Effects of testosterone supplementation on depressive symptoms and sexual dysfunction in hypogonadal men with the metabolic syndrome. J Sex Med 2010;7:2572-2582.
C1 [Giltay, Erik J.] Leiden Univ, Med Ctr, Dept Psychiat, NL-2300 RC Leiden, Netherlands.
   [Tishova, Yuliya A.; Mskhalaya, George J.; Kalinchenko, Svetlana Y.] Peoples Friendship Univ Russia, Chair Endocrinol, Fac Med Staff Refresher Training, Moscow, Russia.
   [Gooren, Louis J. G.] Vrije Univ Amsterdam, Med Ctr, Dept Endocrinol, Amsterdam, Netherlands.
   [Saad, Farid] Bayer Schering Pharma, Sci Affairs Mens Healthcare, Berlin, Germany.
   [Saad, Farid] Gulf Med Univ, Sch Med, Ajman, U Arab Emirates.
C3 Leiden University - Excl LUMC; Leiden University; Leiden University
   Medical Center (LUMC); Peoples Friendship University of Russia; Vrije
   Universiteit Amsterdam; Bayer AG; Bayer Healthcare Pharmaceuticals
RP Giltay, EJ (corresponding author), Leiden Univ, Med Ctr, Dept Psychiat, POB 9600, NL-2300 RC Leiden, Netherlands.
EM giltay@dds.nl
RI Saad, Farid/AAW-2694-2020; Giltay, Erik/AAL-9948-2021
OI Giltay, Erik J./0000-0001-8874-2292
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NR 61
TC 99
Z9 106
U1 0
U2 6
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1743-6095
EI 1743-6109
J9 J SEX MED
JI J. Sex. Med.
PD JUL
PY 2010
VL 7
IS 7
BP 2572
EP 2582
DI 10.1111/j.1743-6109.2010.01859.x
PG 11
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Urology & Nephrology
GA 621XP
UT WOS:000279620100028
PM 20524974
DA 2025-06-11
ER

PT J
AU Morvaridzadeh, M
   Cohen, AA
   Heshmati, J
   Alami, M
   Berrougui, H
   Zoubdane, N
   Pizarro, AB
   Khalil, A
AF Morvaridzadeh, Mojgan
   Cohen, Alan A.
   Heshmati, Javad
   Alami, Mehdi
   Berrougui, Hicham
   Zoubdane, Nada
   Pizarro, Ana Beatriz
   Khalil, Abdelouahed
TI Effect of Extra Virgin Olive Oil on Anthropometric Indices, Inflammatory
   and Cardiometabolic Markers: a Systematic Review and Meta-Analysis of
   Randomized Clinical Trials
SO JOURNAL OF NUTRITION
LA English
DT Article
DE extra virgin olive oil; cardiometabolic biomarkers; glycemic control;
   lipid profile; inflammation
ID CARDIOVASCULAR RISK-FACTORS; CHRONIC KIDNEY-DISEASE; LIPID PROFILE;
   CORN-OIL; SECONDARY PREVENTION; MEDITERRANEAN DIET; OXIDATIVE STRESS;
   BLOOD-PRESSURE; PALM OIL; CHOLESTEROL
AB Background: A large body of literature associated extra virgin olive oil (EVOO) consumption with low risk of cardiovascular disease and mortality. However, findings from clinical trials related to EVOO consumption on blood pressure, lipid profile, and anthropometric and inflammation parameters are not univocal. Objectives: The aim of this systematic review and meta -analysis was to evaluate the effect of EVOO consumption on cardiometabolic risk factors and inflammatory mediators. Methods: We searched PubMed/MEDLINE, Scopus, and Cochrane up through 31 March, 2023, without any particular language limitations, in order to identify randomized controlled trials (RCTs) that examined the effects of EVOO consumption on cardiometabolic risk factors, inflammatory mediators, and anthropometric indices. Outcomes were summarized as standardized mean difference (SMD) with 95% confidence intervals (CIs) estimated from Hedge's g and random -effects modeling. Heterogeneity was assessed by Cochran Q -statistic and quantified (I2). Results: Thirty-three trials involving 2020 participants were included. EVOO consumption was associated with a significant decrease in insulin (n = 10; SMD: -0.28; 95% CI: -0.51, -0.05; I2 = 48.57%) and homeostasis model assessment of insulin resistance levels (HOMA-IR) (n = 9; SMD: -0.19; 95% CI: -0.35, -0.03; I2 = 00.00%). This meta -analysis indicated no significant effect of consuming EVOO on fasting blood glucose, triglycerides, total cholesterol, low density lipoproteins, very low density lipoproteins, high density lipoproteins, Apolipoprotein (Apo) A -I and B, lipoprotein a, blood pressure, body mass index, waist circumference, waist to hip ratio, C -reactive protein, interleukin-6, interleukin-10, and tumor necrosis factor alpha levels (P > 0.05). Conclusions: The present evidence supports a beneficial effect of EVOO consumption on serum insulin levels and HOMA-IR. However, larger well -designed RCTs are still required to evaluate the effect of EVOO on cardiometabolic risk biomarkers. This study was registered in PROSPERO as CRD42023409125.
C1 [Morvaridzadeh, Mojgan; Heshmati, Javad; Alami, Mehdi; Berrougui, Hicham; Zoubdane, Nada; Khalil, Abdelouahed] Univ Sherbrooke, Fac Med & Hlth Sci, Dept Med, Geriatr Unit, Sherbrooke, PQ, Canada.
   [Cohen, Alan A.] Columbia Univ, Butler Columbia Aging Ctr, Mailman Sch Publ Hlth, Dept Environm Hlth Sci, New York, NY USA.
   [Alami, Mehdi; Berrougui, Hicham] Univ Sultan Moulay Slimane, Polydisciplinary Fac, Dept Biol, Beni Mellal, Morocco.
   [Pizarro, Ana Beatriz] Fdn Valle Lili, Clin Res Ctr, Cali, Colombia.
C3 University of Sherbrooke; Columbia University; Sultan Moulay Slimane
   University of Beni Mellal; Fundacion Valle del Lili
RP Khalil, A (corresponding author), Univ Sherbrooke, Fac Med & Hlth Sci, Dept Med, Geriatr Unit, Sherbrooke, PQ, Canada.
EM abdelouahed.khalil@usherbrooke.ca
RI Morvaridzadeh, Mojgan/GLU-6418-2022; heshmati, javad/H-6812-2019;
   Pizarro, Ana/AAC-8021-2022
OI Pizarro, Ana Beatriz/0000-0003-4089-454X
FU Canadian Institutes of Health Research [PJT-162366]
FX This research was funded by the Canadian Institutes of Health Research,
   grant numbers (PJT-162366) .
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NR 79
TC 14
Z9 15
U1 0
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0022-3166
EI 1541-6100
J9 J NUTR
JI J. Nutr.
PD JAN
PY 2024
VL 154
IS 1
BP 95
EP 120
DI 10.1016/j.tjnut.2023.10.028
EA JAN 2024
PG 26
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA ID3G9
UT WOS:001164343100001
PM 37977313
OA Bronze
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Hoemann, K
   Khan, Z
   Kamona, N
   Dy, J
   Barrett, LF
   Quigley, KS
AF Hoemann, Katie
   Khan, Zulqarnain
   Kamona, Nada
   Dy, Jennifer
   Barrett, Lisa Feldman
   Quigley, Karen S.
TI Investigating the relationship between emotional granularity and
   cardiorespiratory physiological activity in daily life
SO PSYCHOPHYSIOLOGY
LA English
DT Article
DE ambulatory assessment; ECG; emotion differentiation; experience
   sampling; heart rate variability; respiratory sinus arrhythmia
ID HEART-RATE-VARIABILITY; RESPIRATORY SINUS ARRHYTHMIA; AUTONOMIC
   NERVOUS-SYSTEM; GROWTH MIXTURE-MODELS; BORDERLINE PERSONALITY; METABOLIC
   SYNDROME; ANXIETY DISORDER; INTEGRATED MODEL; CARDIAC CONTROL; NEGATIVE
   AFFECT
AB Emotional granularity describes the ability to create emotional experiences that are precise and context-specific. Despite growing evidence of a link between emotional granularity and mental health, the physiological correlates of granularity have been under-investigated. This study explored the relationship between granularity and cardiorespiratory physiological activity in everyday life, with particular reference to the role of respiratory sinus arrhythmia (RSA), an estimate of vagal influence on the heart often associated with positive mental and physical health outcomes. Participants completed a physiologically triggered experience-sampling protocol including ambulatory recording of electrocardiogram, impedance cardiogram, movement, and posture. At each prompt, participants generated emotion labels to describe their current experience. In an end-of-day survey, participants elaborated on each prompt by rating the intensity of their experience on a standard set of emotion adjectives. Consistent with our hypotheses, individuals with higher granularity exhibited a larger number of distinct patterns of physiological activity during seated rest, and more situationally precise patterns of activity during emotional events: granularity was positively correlated with the number of clusters of cardiorespiratory physiological activity discovered in seated rest data, as well as with the performance of classifiers trained on event-related changes in physiological activity. Granularity was also positively associated with RSA during seated rest periods, although this relationship did not reach significance in this sample. These findings are consistent with constructionist accounts of emotion that propose concepts as a key mechanism underlying individual differences in emotional experience, physiological regulation, and physical health.
C1 [Hoemann, Katie] Katholieke Univ Leuven, Dept Psychol, Leuven, Belgium.
   [Khan, Zulqarnain; Dy, Jennifer] Northeastern Univ, Dept Elect & Comp Engn, Boston, MA 02115 USA.
   [Kamona, Nada; Barrett, Lisa Feldman; Quigley, Karen S.] Northeastern Univ, Dept Psychol, Boston, MA 02115 USA.
   [Barrett, Lisa Feldman] Harvard Med Sch, Massachusetts Gen Hosp, Dept Psychiat, Boston, MA 02115 USA.
   [Barrett, Lisa Feldman] Massachusetts Gen Hosp, Athinoula A Martinos Ctr Biomed Imaging, Charlestown, MA USA.
   [Quigley, Karen S.] Edith Nourse Rogers Mem Vet Hosp, Ctr Healthcare Org & Implementat Res, Bedford, MA USA.
C3 KU Leuven; Northeastern University; Northeastern University; Harvard
   University; Harvard Medical School; Harvard University Medical
   Affiliates; Massachusetts General Hospital; Harvard University; Harvard
   University Medical Affiliates; Massachusetts General Hospital
RP Hoemann, K (corresponding author), Katholieke Univ Leuven, Dept Psychol, Leuven, Belgium.
EM khoemann@gmail.com
RI Barrett, Lisa/ABC-8157-2020; Hoemann, Katie/J-6320-2019; Quigley,
   Karen/B-9003-2013
OI Quigley, Karen/0000-0001-8844-990X; Kamona, Nada/0000-0002-4382-876X;
   Barrett, Lisa/0000-0003-4478-2051
FU National Heart, Lung, and Blood Institute [1F31HL140943-01]; P.E.O.
   International Scholar Award; U.S. Army Research Institute for the
   Behavioral and Social Sciences [W911NF-16-1-0191]
FX This work was performed at Northeastern University in partial
   fulfillment of a Doctor of Philosophy Degree in Psychology awarded to
   Katie Hoemann. K.H. was supported by the National Heart, Lung, and Blood
   Institute (grant number 1F31HL140943-01) and a P.E.O. International
   Scholar Award. This work was further supported by the U.S. Army Research
   Institute for the Behavioral and Social Sciences (grant number
   W911NF-16-1-0191 to K.S.Q. and Dr. Jolie Wormwood, Co-PIs). The views,
   opinions, and/or findings contained in this paper are those of the
   authors and shall not be construed as an official Department of the Army
   position, policy, or decision, unless so designated by other documents.
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NR 147
TC 19
Z9 24
U1 6
U2 39
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0048-5772
EI 1469-8986
J9 PSYCHOPHYSIOLOGY
JI Psychophysiology
PD JUN
PY 2021
VL 58
IS 6
AR e13818
DI 10.1111/psyp.13818
EA MAR 2021
PG 18
WC Psychology, Biological; Neurosciences; Physiology; Psychology;
   Psychology, Experimental
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Neurosciences & Neurology; Physiology
GA SK5UD
UT WOS:000632679100001
PM 33768687
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Dabek, J
   Wilczok, T
   Gasior, Z
   Kucia-Kuzma, S
   Twardowski, R
   Kulach, A
AF Dabek, Jozefa
   Wilczok, Tadeusz
   Gasior, Zbigniew
   Kucia-Kuzma, Sylwia
   Twardowski, Romuald
   Kulach, Andrzej
TI Gene expression of kinin receptors B1 and B2 in PBMC from patients with
   cardiac syndrome X
SO SCANDINAVIAN CARDIOVASCULAR JOURNAL
LA English
DT Article
DE cardiac syndrome X; kinin receptors; gene expression; mononuclear cells
ID LEFT-VENTRICULAR FUNCTION; CORONARY-ARTERY; B-1 RECEPTORS; BRADYKININ;
   DISEASE; INFLAMMATION; PROGNOSIS; COMPLEX; SYSTEM; CELLS
AB Introduction. Cardiac syndrome X (CSX) is defined by typical chest pain, ST segment depression on ECG and normal coronary angiography. Pathology of CSX may involve microvascular dysfunction related to inflammation and abnormal pain sensitivity. Kinins are labile peptides participating in vasodilation, inflammation and pain. Their effects are mediated by two receptors: B1 and B2. The aim of the study was to assess gene expression of kinin receptors in peripheral blood mononuclear cells (PBMC) from patients with CSX. Methods. The study was carried out in 34 patients with cardiac syndrome X, 13 with unstable angina and ten healthy subjects. Total mRNA was extracted from PBMC and the number of mRNA copies was assessed by quantitive reverse transcriptase polymerase chain reaction. Results and Conclusion. The study showed 7-fold higher transcriptional activity of B1R in CSX vs. control and 3.5 higher vs. UA. B2R expression was 2.5-fold higher in CSX group vs. control and UA, while in the letter two groups it was similar. Such disturbance in kinin signaling may participate in local vasoconstriction and may reflect disturbances in kinin signaling leading to nociceptive disturbances in these patients.
C1 L Warynski Silesian Med Acad, Dept Cardiol, PL-40635 Katowice, Poland.
   L Warynski Silesian Med Acad, Dept Mol Biol & Med Genet, Sosnowiec, Poland.
C3 Medical University of Silesia; Medical University of Silesia
RP Kulach, A (corresponding author), L Warynski Silesian Med Acad, Dept Cardiol, Ziolowa 47, PL-40635 Katowice, Poland.
EM akulach@mp.pl
RI Kulach, Andrzej/ABF-3313-2020
OI Gasior, Zbigniew/0000-0003-3616-8932; Dabek, Jozefa/0000-0002-8257-6614;
   Kulach, Andrzej/0000-0002-3140-1806
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NR 24
TC 7
Z9 7
U1 0
U2 0
PU TAYLOR & FRANCIS AS
PI OSLO
PA PO BOX 12 POSTHUSET, NO-0051 OSLO, NORWAY
SN 1401-7431
J9 SCAND CARDIOVASC J
JI Scand. Cardiovasc. J.
PY 2007
VL 41
IS 6
BP 391
EP 396
DI 10.1080/14017430701499379
PG 6
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 234EJ
UT WOS:000251143200007
PM 17852785
DA 2025-06-11
ER

PT J
AU Derry, HM
   Fagundes, CP
   Andridge, R
   Glaser, R
   Malarkey, WB
   Kiecolt-Glaser, JK
AF Derry, Heather M.
   Fagundes, Christopher P.
   Andridge, Rebecca
   Glaser, Ronald
   Malarkey, William B.
   Kiecolt-Glaser, Janice K.
TI Lower subjective social status exaggerates interleukin-6 responses to a
   laboratory stressor
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE Subjective social status; Inflammation; Interleukin-6 (IL-6); Laboratory
   stressor
ID INDUCED INFLAMMATORY RESPONSES; LPS-INDUCED CYTOKINE;
   SOCIOECONOMIC-STATUS; CARDIOVASCULAR REACTIVITY; DEPRESSIVE SYMPTOMS;
   CORTISOL RESPONSES; INSULIN-RESISTANCE; METABOLIC SYNDROME; INDUCED
   INCREASES; MAJOR DEPRESSION
AB Growing evidence suggests that lower subjective social status (SSS), which reflects where a person positions himself on a social ladder in relation to others, is independently related to poor health. People who rate themselves lower in status also experience more frequent stressors and report higher stress than those who rate themselves higher in status, and chronic stress can enhance an individual's response to subsequent stressors. To address whether SSS predicted stress-induced interleukin-6 (IL-6) changes, we assessed 138 healthy adults at rest and following the Trier Social Stress Test (TSST). Participants completed the TSST at two study visits, separated by 4 months. People who placed themselves lower on the social ladder had larger IL-6 responses from baseline to 45 min post-stressor (p = 0.01) and from baseline to 2 h post-stressor (p = 0.03) than those who placed themselves higher on the social ladder. Based on a ratio of subjective threat and coping ratings of the stress task, participants who viewed themselves as lower in status also tended to rate the speech task as more threatening and less manageable than those who viewed themselves as higher in status (p = 0.05). These data suggest that people with tower perceived status experience greater physiological and psychological burden from brief stressors compared to those with higher perceived status. Accordingly, responses to stressors may be a possible mechanistic link among SSS, stress, and health. (C) 2013 Elsevier Ltd. All rights reserved.
C1 [Derry, Heather M.; Glaser, Ronald; Malarkey, William B.; Kiecolt-Glaser, Janice K.] Ohio State Univ, Coll Med, Inst Behav Med Res, Columbus, OH 43210 USA.
   [Derry, Heather M.; Kiecolt-Glaser, Janice K.] Ohio State Univ, Dept Psychol, Columbus, OH 43210 USA.
   [Fagundes, Christopher P.] Univ Texas MD Anderson Canc Ctr, Dept Hlth Dispar Res, Houston, TX 77030 USA.
   [Andridge, Rebecca] Ohio State Univ, Coll Publ Hlth, Div Biostat, Columbus, OH 43210 USA.
   [Glaser, Ronald; Malarkey, William B.] Ohio State Univ, Coll Med, Dept Internal Med, Columbus, OH 43210 USA.
   [Glaser, Ronald] Ohio State Univ, Coll Med, Dept Mol Virol Immunol & Med Genet, Columbus, OH 43210 USA.
   [Glaser, Ronald; Malarkey, William B.; Kiecolt-Glaser, Janice K.] Ohio State Univ, Coll Med, Ctr Comprehens Canc, Columbus, OH 43210 USA.
   [Kiecolt-Glaser, Janice K.] Ohio State Univ, Coll Med, Dept Psychiat, Columbus, OH 43210 USA.
C3 University System of Ohio; Ohio State University; University System of
   Ohio; Ohio State University; University of Texas System; UTMD Anderson
   Cancer Center; University System of Ohio; Ohio State University;
   University System of Ohio; Ohio State University; University System of
   Ohio; Ohio State University; James Cancer Hospital & Solove Research
   Institute; University System of Ohio; Ohio State University; University
   System of Ohio; Ohio State University
RP Derry, HM (corresponding author), Ohio State Univ, Coll Med, Inst Behav Med Res, 460 Med Ctr Dr, Columbus, OH 43210 USA.
EM Heather.Derry@osumc.edu
RI ; Andridge, Rebecca/C-8457-2012
OI Derry-Vick, Heather/0000-0003-0753-0859; Andridge,
   Rebecca/0000-0001-9991-9647
FU NIH [AG029562, AG038621, UL1TR000090, CA16058]; S. Robert Davis
   endowment; Kathryn a Gilbert Mitchell endowment; American Cancer Society
   [PF-11-007-01-CPPB]
FX Work on this project was supported in part by NIH Grants AG029562,
   AG038621, UL1TR000090, CA16058, the S. Robert Davis endowment, the
   Kathryn a Gilbert Mitchell endowment, and American Cancer Society
   Postdoctoral Fellowship Grant PF-11-007-01-CPPB. OmegaBrite (Waltham,
   MA) supplied the omega-3 supplement and placebo without charge and
   without restrictions. OmegaBrite did not influence the design, funding,
   implementation, interpretation, or publication of the data.
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NR 63
TC 75
Z9 83
U1 0
U2 28
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD NOV
PY 2013
VL 38
IS 11
BP 2676
EP 2685
DI 10.1016/j.psyneuen.2013.06.026
PG 10
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA 268MT
UT WOS:000328175700028
PM 23849596
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Hough, CM
   Bersani, FS
   Mellon, SH
   Morford, AE
   Lindqvist, D
   Reus, VI
   Epel, ES
   Wolkowitz, OM
AF Hough, Christina M.
   Bersani, F. Saverio
   Mellon, Synthia H.
   Morford, Alexandra E.
   Lindqvist, Daniel
   Reus, Victor I.
   Epel, Elissa S.
   Wolkowitz, Owen M.
TI Pre-treatment allostatic load and metabolic dysregulation predict SSRI
   response in major depressive disorder: a preliminary report
SO PSYCHOLOGICAL MEDICINE
LA English
DT Article
DE Allostatic load; antidepressant response; major depressive disorder;
   metabolic dysregulation; metabolic syndrome; treatment prediction;
   treatment response
ID LATE-LIFE DEPRESSION; DEHYDROEPIANDROSTERONE DHEA; HIPPOCAMPAL
   NEUROGENESIS; TREATMENT OUTCOMES; CHRONIC STRESS; ASSOCIATION;
   REMISSION; OBESITY; METAANALYSIS; CHOLESTEROL
AB Background Major depressive disorder (MDD) is associated with increased allostatic load (AL; a measure of physiological costs of repeated/chronic stress-responding) and metabolic dysregulation (MetD; a measure of metabolic health and precursor to many medical illnesses). Though AL and MetD are associated with poor somatic health outcomes, little is known regarding their relationship with antidepressant-treatment outcomes. Methods We determined pre-treatment AL and MetD in 67 healthy controls and 34 unmedicated, medically healthy MDD subjects. Following this, MDD subjects completed 8-weeks of open-label selective serotonin reuptake inhibitor (SSRI) antidepressant treatment and were categorized as 'Responders' (> 50% improvement in depression severity ratings) or 'Non-responders' (<50% improvement). Logistic and linear regressions were performed to determine if pre-treatment AL or MetD scores predicted SSRI-response. Secondary analyses examined cross-sectional differences between MDD and control groups. Results Pre-treatment AL and MetD scores significantly predicted continuous antidepressant response (i.e. absolute decreases in depression severity ratings) (p = 0.012 and 0.014, respectively), as well as post-treatment status as a Responder or Non-responder (p = 0.022 and 0.040, respectively), such that higher pre-treatment AL and MetD were associated with poorer SSRI-treatment outcomes. Pre-treatment AL and MetD of Responders were similar to Controls, while those of Non-responders were significantly higher than both Responders (p = 0.025 and 0.033, respectively) and Controls (p = 0.039 and 0.001, respectively). Conclusions These preliminary findings suggest that indices of metabolic and hypothalamic-pituitary-adrenal-axis dysregulation are associated with poorer SSRI-treatment response. To our knowledge, this is the first study to demonstrate that these markers of medical disease risk also predict poorer antidepressant outcomes.
C1 [Hough, Christina M.; Bersani, F. Saverio; Morford, Alexandra E.; Lindqvist, Daniel; Reus, Victor I.; Epel, Elissa S.; Wolkowitz, Owen M.] Univ Calif San Francisco, Sch Med, Dept Psychiat, UCSF Weill Inst Neurosci, San Francisco, CA 94143 USA.
   [Hough, Christina M.] Univ Calif Los Angeles, Dept Psychol, 405 Hilgard Ave, Los Angeles, CA 90024 USA.
   [Bersani, F. Saverio] Sapienza Univ Rome, Dept Human Neurosci, Rome, Italy.
   [Mellon, Synthia H.] Univ Calif San Francisco, Sch Med, Dept Obstet Gynecol & Reprod Sci, San Francisco, CA USA.
   [Morford, Alexandra E.] Northwestern Univ, Feinberg Sch Med, Dept Psychiat & Behav Sci, Chicago, IL 60611 USA.
   [Lindqvist, Daniel] Lund Univ, Dept Clin Sci, Sect Psychiat, Lund, Sweden.
C3 University of California System; University of California San Francisco;
   University of California System; University of California Los Angeles;
   Sapienza University Rome; University of California System; University of
   California San Francisco; Northwestern University; Feinberg School of
   Medicine; Lund University
RP Hough, CM (corresponding author), Univ Calif San Francisco, Sch Med, Dept Psychiat, UCSF Weill Inst Neurosci, San Francisco, CA 94143 USA.; Hough, CM (corresponding author), Univ Calif Los Angeles, Dept Psychol, 405 Hilgard Ave, Los Angeles, CA 90024 USA.
EM cmhough@ucla.edu
RI Bersani, F./H-7234-2019; Epel, Elissa/ABI-6703-2022; Wolkowitz,
   Owen/J-6649-2013; reus, victor/I-7923-2015
OI Bersani, Francesco Saverio/0000-0002-7555-8020
FU National Institute of Mental Health (NIMH) [R01-MH083784]; O'Shaughnessy
   Foundation; UCSF Research Evaluation and Allocation Committee (REAC);
   National Institutes of Health/National Center for Research Resources
   (NIH/NCRR); NIH National Center for Advancing Translational Sciences
   (UCSF-CTSI Grant) [UL1 RR024131]; UCLA Graduate Division; National
   Science Foundation Graduate Research Fellowship Program (NSF)
   [DGE-1650604]; Swedish Research Council [2015-00387]; Marie Sklodowska
   Curie Actions [INCA 600398]; Swedish Society of Medicine; Sjobring
   Foundation; OM Persson Foundation; province of Scania (Sweden); UCSF
   Academic Senate; Soderstrom-Konigska Foundation
FX The authors gratefully acknowledge the assistance of Kevin Delucchi,
   PhD, Phuong Hoang, and Alanie Lazaro of UCSF, the Mendoza Lab of UC
   Davis, and the UCSF CTSI Clinical Research Center staff. This study was
   funded by the National Institute of Mental Health (NIMH) (Grant
   R01-MH083784), O'Shaughnessy Foundation, Tinberg family, UCSF Academic
   Senate, and UCSF Research Evaluation and Allocation Committee (REAC),
   and supported by National Institutes of Health/National Center for
   Research Resources (NIH/NCRR) and NIH National Center for Advancing
   Translational Sciences (UCSF-CTSI Grant UL1 RR024131). C.M.H. is
   supported by funding provided by UCLA Graduate Division and the National
   Science Foundation Graduate Research Fellowship Program (NSF Grant
   DGE-1650604). D.L. is supported by the Swedish Research Council
   (registration number 2015-00387), Marie Sklodowska Curie Actions, Cofund
   (Project INCA 600398), Swedish Society of Medicine, Soderstrom-Konigska
   Foundation, Sjobring Foundation, OM Persson Foundation and the province
   of Scania (Sweden) state grants (ALF). No granting or funding agency had
   a role in the study design and conduct; data collection, management,
   analysis and interpretation; or manuscript preparation, review, or
   approval. All authors had full access to all of the data in the study
   and take responsibility for the integrity of the data and the accuracy
   of the data analysis. The contents of this publication are solely the
   responsibility of the authors and do not necessarily represent the
   official views of the NIH.
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NR 53
TC 14
Z9 15
U1 1
U2 11
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
SN 0033-2917
EI 1469-8978
J9 PSYCHOL MED
JI Psychol. Med.
PD SEP
PY 2021
VL 51
IS 12
BP 2117
EP 2125
AR PII S0033291720000896
DI 10.1017/S0033291720000896
PG 9
WC Psychology, Clinical; Psychiatry; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA UL8PL
UT WOS:000692906900018
PM 32438932
DA 2025-06-11
ER

PT J
AU Poursafa, P
   Mansourian, M
   Motlagh, ME
   Ardalan, G
   Kelishadi, R
AF Poursafa, Parinaz
   Mansourian, Marjan
   Motlagh, Mohammad-Esmaeil
   Ardalan, Gelayol
   Kelishadi, Roya
TI Is air quality index associated with cardiometabolic risk factors in
   adolescents? The CASPIAN-III Study
SO ENVIRONMENTAL RESEARCH
LA English
DT Article
DE Air pollutants; Cardiovascular risk factors; Adolescents; Prevention;
   Public health
ID CARDIOVASCULAR-DISEASE RISK; POLLUTION EXPOSURE; PARTICULATE MATTER;
   ENDOTHELIAL DYSFUNCTION; INSULIN-RESISTANCE; OXIDATIVE STRESS;
   MIDDLE-EAST; CHILDREN; INFLAMMATION; TEMPERATURE
AB Objective: This study aims to evaluate the association of air quality index (AQI) with cardiometabolic risk factors in a nationally representative sample of healthy adolescents.
   Methods: This nationwide survey was conducted among a stratified multi-stage probability sample of students, aged 10-18 years, from 27 provinces of Iran. Those students with history of any acute or chronic diseases, any medication use, as well as active or passive smoking were not included to the current study. Dietary and physical activity habits were documented by valid questionnaires. Physical examination and blood sampling were conducted under standard protocols. AQI data were obtained from air pollution monitoring sites from the entire country by considering air pollutants concentration, which includes all provincial counties containing different clusters.
   Results: The study participants consisted of 1413 students (48.8% boys) with a mean (SD) age of 14.81 +/- 2.48 years. The mean AQI level was 285.37 +/- 30.11 at national levels. After adjustment for confounding factors including age, sex, and anthropometric measures, as well as for dietary and physical activity habits, multiple linear regressions based on correlation of coefficients of the AI:T with cardiometabolic risk factors showed significant positive correlations of AQJ with systolic blood pressure, fasting blood glucose, total cholesterol, LDL-cholesterol, and triglycerides, as well as significant negative correlations with HDL-cholesterol. After adjustment for abovementioned confounding factors, binary logistic regressions analyses showed that AQI increased the risk of abnormal levels of some risk factors as elevated levels of systolic blood pressure, total cholesterol, and triglycerides.
   Conclusion: The associations of low air quality with some cardiometabolic factors in the current survey, although not strong, might be considered as an evidence of the adverse cardiometabolic consequences of exposure to air pollutants in the pediatric age group, and predisposing them to earlier development of noncommunicable diseases. (C) 2014 Elsevier Inc. All rights reserved.
C1 [Poursafa, Parinaz] Isfahan Univ Med Sci, Environm Res Ctr, Dept Environm Engn, Esfahan, Iran.
   [Mansourian, Marjan] Isfahan Univ Med Sci, Fac Publ Hlth, Dept Biostat & Epidemiol, Esfahan, Iran.
   [Mansourian, Marjan; Ardalan, Gelayol; Kelishadi, Roya] Isfahan Univ Med Sci, Child Growth & Dev Res Ctr, Dept Pediat, Esfahan, Iran.
   [Motlagh, Mohammad-Esmaeil] Ahvaz jundishapur Univ Med Sci, Dept Pediat, Ahvaz, Iran.
C3 Isfahan University of Medical Sciences; Isfahan University of Medical
   Sciences; Isfahan University of Medical Sciences; Ahvaz Jundishapur
   University of Medical Sciences (AJUMS)
RP Kelishadi, R (corresponding author), Isfahan Univ Med Sci, Child Growth & Dev Res Ctr, Dept Pediat, Esfahan, Iran.
EM kelishadi@med.mui.ac.ir
RI Mansourian, Marjan/AAX-1011-2020; motlagh, Mohammad/AAC-2653-2019;
   Poursafa, Parinaz/U-2924-2017; Kelishadi, Roya/E-6154-2012
OI Mansourian, Marjan/0000-0002-7217-0282; motlagh, mohammad
   esmaiel/0000-0002-2971-8660; Poursafa, Parinaz/0000-0002-8067-4122;
   Kelishadi, Roya/0000-0001-7455-1495
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NR 40
TC 61
Z9 69
U1 1
U2 23
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0013-9351
EI 1096-0953
J9 ENVIRON RES
JI Environ. Res.
PD OCT
PY 2014
VL 134
SI SI
BP 105
EP 109
DI 10.1016/j.envres.2014.07.010
PG 5
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA AX3CB
UT WOS:000346817100015
PM 25127520
DA 2025-06-11
ER

PT J
AU Wright, S
   Strunk, A
   Garg, A
AF Wright, Shari
   Strunk, Andrew
   Garg, Amit
TI New-onset depression among children, adolescents, and adults with
   hidradenitis suppurativa
SO JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
LA English
DT Article
DE comorbidity; depression; Explorys; hidradenitis suppurativa; incidence;
   mood disorder; new-onset
ID QUALITY-OF-LIFE; METABOLIC SYNDROME; MAJOR DEPRESSION; PREVALENCE;
   DISEASE; ASSOCIATION; INSTRUMENTS; BURDEN
AB Background: Information on the risk of depression among children, adolescents, and adults with hidradenitis suppurativa (HS) is limited.
   Objective: To compare the risk of new-onset depression in patients with HS with that of control individuals.
   Methods: Retrospective cohort analysis of 49,280 adult and 3042 pediatric patients with HS and matched control individuals identified by using electronic health record data. The primary outcome was incident depression.
   Results: The crude incidence rate was 4.8 per 100 person-years in adult patients with HS compared to 3.0 per 100 person-years in control individuals. Among pediatric patients, the crude incidence rate was 4.2 per 100 person-years in patients with HS compared with 2.3 per 100 person-years in control individuals. In adjusted analysis, adults and pediatric patients with HS had a 10% (hazard ratio, 1.10; 95% confidence interval, 1.07-1.13; P<.001) and 26% (hazard ratio, 1.26; 95% confidence interval, 1.10-1.44; P<.001), respectively, increased risk of developing depression compared to control individuals. Among patients with HS, factors associated with depression included female sex, white race, smoking, and body mass index/obesity in adults and pediatric patients and substance abuse in adults only.
   Limitations: Patients not seeking care in health systems within the database were not captured.
   Conclusion: Children, adolescents, and adults with HS are at an increased risk for developing depression, independent of other common risk factors for depression.
C1 [Wright, Shari; Strunk, Andrew; Garg, Amit] Donald & Barbara Zucker Sch Med Hofstra Northwell, Dept Dermatol, New Hyde Pk, NY 11042 USA.
C3 Northwell Health
RP Garg, A (corresponding author), Donald & Barbara Zucker Sch Med Hofstra Northwell, 1991 Marcus Ave,Suite 300, New Hyde Pk, NY 11042 USA.
EM amgarg@northwell.edu
RI Garg, Amit/JEO-9043-2023
OI Garg, Amit/0000-0003-0886-6856
FU AbbVie
FX Supported in part by an education grant from AbbVie. AbbVie had no role
   in the design and conduct of the study; collection, management,
   analysis, and interpretation of the data; preparation, review, or
   approval of the manuscript; and decision to submit the manuscript for
   publication.
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NR 40
TC 28
Z9 28
U1 0
U2 3
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0190-9622
EI 1097-6787
J9 J AM ACAD DERMATOL
JI J. Am. Acad. Dermatol.
PD NOV
PY 2020
VL 83
IS 5
BP 1360
EP 1366
DI 10.1016/j.jaad.2020.05.090
PG 7
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA OH3XJ
UT WOS:000582505200043
PM 32446831
DA 2025-06-11
ER

PT J
AU Ferreira, YAM
   Kravchychyn, ACP
   Vicente, SDF
   Campos, RMD
   Tock, L
   Oyama, LM
   Boldarine, VT
   Masquio, DCL
   Thivel, D
   Shivappa, N
   Hébert, JR
   Dâmaso, AR
AF Martins Ferreira, Yasmin Alaby
   Pelissari Kravchychyn, Ana Claudia
   Ferreira Vicente, Sofia de Castro
   da Silveira Campos, Raquel Munhoz
   Tock, Lian
   Oyama, Lila Missae
   Boldarine, Valter Tadeu
   Landi Masquio, Deborah Cristina
   Thivel, David
   Shivappa, Nitin
   Hebert, James R.
   Damaso, Ana R.
TI An Interdisciplinary Weight Loss Program Improves Body Composition and
   Metabolic Profile in Adolescents With Obesity: Associations With the
   Dietary Inflammatory Index
SO FRONTIERS IN NUTRITION
LA English
DT Article
DE inflammatory diet; cardiometabolic risk; interdisciplinary therapy;
   obesity; inflammation
ID LIFE-STYLE INTERVENTION; INSULIN-RESISTANCE; CARDIOMETABOLIC RISK; WAIST
   CIRCUMFERENCE; CARDIOVASCULAR RISK; NECK CIRCUMFERENCE; ADIPONECTIN;
   EXERCISE; LEPTIN; PATTERN
AB Background and Aims: The prevalence of overweight and obesity consitutes a global epidemic and it is growing around the world. Food and nutrition are essential requirements for promoting health and protecting against non-communicable chronic diseases, such as obesity and cardiovascular disease. Specific dietary components may modulate inflammation and oxidative stress in obese individuals. The Dietary Inflammatory Index (DII (R)) was developed to characterize the anti- and pro-inflammatory effects of individuals' diet. Few studies have investigated the role of diet-associated inflammation in adolescents with obesity. The present study aims to investigate the effects of an interdisciplinary weight loss therapy on DII scores and cardiometabolic risk in obese adolescents and possibles correlations.
   Methods: A total of 45 volunteers (14-19 years old) were recruited and enrolled for long-term interdisciplinary therapy including clinical, nutritional, psychological counseling, and exercise training. Adolescents had access to videos about health education weekly. Body composition and inflammatory and serum profiles were evaluated at baseline and after intervention. The food intake was obtained by 24-h food recall. Data was used to calculate energy-adjusted DII (E-DII) scores. Negative scores indicate an anti-inflammatory diet and positive scores indicates a pro-inflammatory diet. The sample was divided according to whether individuals increased or decreased E-DII scores after therapy.
   Results: After therapy the body mass index (BMI), body weight, body fat, abdominal, waist, neck, and hip circumferences decreased significantly. The mean of high-density lipoprotein cholesterol (HDL-c) increased after the therapy. There was found an improvement of inflammatory and cardiometabolic parameters. In exploratory analyses, this occurred mainly when the EDII improved.
   Conclusion: Long-term interdisciplinary therapy combined with a health education website improved inflammatory serum markers in obese adolescents. Reduction in DII scores was associated with reduction of cardiometabolic parameters, suggesting that an anti-inflammatory diet may be an effective strategy to prevent and treat obesity and related comorbidities.
C1 [Martins Ferreira, Yasmin Alaby; Pelissari Kravchychyn, Ana Claudia; Ferreira Vicente, Sofia de Castro; Oyama, Lila Missae; Damaso, Ana R.] Univ Fed Sao Paulo, Escoia Paulista Med, Post Grad Program Nutr, Sao Paulo, Brazil.
   [da Silveira Campos, Raquel Munhoz] Univ Fed Sao Carlos UFSCar, Therapeut Resources Lab, Dept Physiotherapy, Sao Carlos, SP, Brazil.
   [Tock, Lian] Univ Fed Sao Paulo, Post Grad Program Nutr, Sao Paulo, Brazil.
   [Oyama, Lila Missae; Boldarine, Valter Tadeu] Univ Fed Sao Paulo, Dept Physiol, Escola Paulista Med, Sao Paulo, Brazil.
   [Landi Masquio, Deborah Cristina] Ctr Univ Sao Camilo, Sao Paulo, Brazil.
   [Thivel, David] Clermont Auvergne Univ, EA 3533, Lab Metab Adaptat Exercise Physiol & Pathol Condi, Clermont Ferrand, France.
   [Thivel, David] CRNH Auvergne, Clermont Ferrand, France.
   [Shivappa, Nitin; Hebert, James R.] Univ South Carolina, Canc Prevent & Control Program, Columbia, SC 29208 USA.
   [Shivappa, Nitin; Hebert, James R.] Univ South Carolina, Arnold Sch Publ Hlth, Dept Epidemiol & Biostat, Columbia, SC 29208 USA.
   [Shivappa, Nitin; Hebert, James R.] Connecting Hlth Innovat LLC CHI, Columbia, SC USA.
   [da Silveira Campos, Raquel Munhoz] Univ Fed Sao Paulo UNIFESP, Post Grad Program Interdisciplinary Hlth Sci, Santos, Brazil.
   [da Silveira Campos, Raquel Munhoz] Univ Fed Sao Paulo UNIFESP, Dept Biosci, Santos, Brazil.
C3 Universidade Federal de Sao Paulo (UNIFESP); Universidade Federal de Sao
   Carlos; Universidade Federal de Sao Paulo (UNIFESP); Universidade
   Federal de Sao Paulo (UNIFESP); Centro Universitario Sao Camilo;
   Universite Clermont Auvergne (UCA); University of South Carolina System;
   University of South Carolina Columbia; University of South Carolina
   System; University of South Carolina Columbia; Connecting Health
   Innovations LLC; Universidade Federal de Sao Paulo (UNIFESP);
   Universidade Federal de Sao Paulo (UNIFESP)
RP Ferreira, YAM; Oyama, LM (corresponding author), Univ Fed Sao Paulo, Escoia Paulista Med, Post Grad Program Nutr, Sao Paulo, Brazil.; Oyama, LM (corresponding author), Univ Fed Sao Paulo, Dept Physiol, Escola Paulista Med, Sao Paulo, Brazil.
EM yasminalaby@hotmali.com; lmoyama@gmail.com
RI Shivappa, Nitin/X-2215-2018; Hebert, James/IUO-5628-2023; Oyama,
   Lila/B-7609-2012; Kravchychyn, Ana/B-2114-2018; Ferreira,
   Yasmin/ABC-4898-2020; Masquio, Deborah/GLQ-5953-2022; Dâmaso,
   Ana/AAT-6058-2021; Boldarine, Valter/AAC-9086-2020; Campos,
   Raquel/D-1994-2013
OI Campos, Raquel/0000-0001-6132-4349; Pelissari Kravchychyn, Ana
   Claudia/0000-0002-2919-2806
FU Foundation of Sao Paulo Research-FAPESP [2017/07372-1, 2015/143099];
   National Council for Scientific and Technological Development-CNPq
   [300654/2013-8, 409943/2016-9, 301322/2017-1]; Coordination of Higher
   Education Personnel Training-CAPES
FX This work was supported by: Foundation of Sao Paulo Research-FAPESP
   [2017/07372-1; 2015/143099], National Council for Scientific and
   Technological Development-CNPq [300654/2013-8 and 409943/2016-9;
   301322/2017-1], and Coordination of Higher Education Personnel
   Training-CAPES.
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NR 74
TC 22
Z9 23
U1 2
U2 9
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD JUN 3
PY 2019
VL 6
AR 77
DI 10.3389/fnut.2019.00077
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA IC1YT
UT WOS:000470756700001
PM 31214594
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Ong, P
   Athanasiadis, A
   Mahrholdt, H
   Borgulya, G
   Sechtem, U
   Kaski, JC
AF Ong, Peter
   Athanasiadis, Anastasios
   Mahrholdt, Heiko
   Borgulya, Gabor
   Sechtem, Udo
   Kaski, Juan Carlos
TI Increased coronary vasoconstrictor response to acetylcholine in women
   with chest pain and normal coronary arteriograms (cardiac syndrome X)
SO CLINICAL RESEARCH IN CARDIOLOGY
LA English
DT Article
DE Cardiac syndrome X; Microvascular angina; Vasoconstriction;
   Acetylcholine
ID ENDOTHELIAL FUNCTION; ANGINA-PECTORIS; ARTERY-DISEASE;
   MYOCARDIAL-ISCHEMIA; SEGMENT DEPRESSION; EXERCISE; SPASM;
   PATHOPHYSIOLOGY; INHIBITION; HEART
AB Cardiac syndrome X (CSX) is characterized by exercise-induced angina, positive exercise stress-test responses and angiographically normal coronary arteries. The condition characteristically affects more women than men and is often associated with coronary microvascular dysfunction, i.e., abnormal vasodilatory responses. Recent clinical observations suggest that increased coronary vasoconstriction may have a pathogenic role in CSX. We therefore sought to assess the prevalence of increased epicardial and microvascular coronary vasoconstriction in women with CSX.
   Among 1,120 consecutive women with angina undergoing diagnostic coronary angiography 39 fulfilled criteria for CSX (mean age 63 +/- A 9 years) and were included in the study (27 also complained about rest angina). Five women without angina (mean age 64 +/- A 24 years) and normal coronary arteriograms served as controls. Patients and controls underwent intracoronary acetylcholine testing with a standardized protocol. Severe (a parts per thousand yen75 % diameter reduction) epicardial constriction developed in 12 CSX patients (31 %) with reproduction of their angina in 10. All 12 patients showed diffuse epicardial constriction affecting mainly the distal coronary segments. Twenty-two CSX patients (56 %) experienced their usual angina without epicardial constriction of which 21 had ischemic ECG shifts. The remaining five CSX patients (13 %) had no angina or constriction in response to acetylcholine. None of the control patients had angina or constriction during ACH testing.
   Increased epicardial as well as microvascular coronary constriction in response to acetylcholine are frequent findings in women with CSX. The results indicate that inappropriate coronary constriction is likely to contribute to the anginal symptoms of these patients. The ACH-test may be useful in the clinical setting to unmask this vasomotor disorder.
C1 [Ong, Peter; Athanasiadis, Anastasios; Mahrholdt, Heiko; Sechtem, Udo] Robert Bosch Krankenhaus, Dept Cardiol, D-70376 Stuttgart, Germany.
   [Borgulya, Gabor] St Georges Univ London, Clin Trials Unit, London, England.
   [Kaski, Juan Carlos] St Georges Univ London, Cardiovasc Sci Res Ctr, London, England.
C3 Bosch; Robert Bosch Krankenhaus; City St Georges, University of London;
   St Georges University London; City St Georges, University of London; St
   Georges University London
RP Ong, P (corresponding author), Robert Bosch Krankenhaus, Dept Cardiol, Auerbachstr 110, D-70376 Stuttgart, Germany.
EM Peter.Ong@rbk.de
RI Kaski, Juan Carlos/LKM-8031-2024; Sechtem, Udo/ADK-6380-2022
OI Borgulya, Gabor/0000-0001-6396-6126
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NR 38
TC 38
Z9 38
U1 0
U2 5
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1861-0684
EI 1861-0692
J9 CLIN RES CARDIOL
JI Clin. Res. Cardiol.
PD AUG
PY 2012
VL 101
IS 8
BP 673
EP 681
DI 10.1007/s00392-012-0442-4
PG 9
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 975CQ
UT WOS:000306484800010
PM 22407462
DA 2025-06-11
ER

PT J
AU Gunderson, EP
   Quesenberry, CP
   Ning, X
   Jacobs, DR
   Gross, M
   Goff, DC
   Pletcher, MJ
   Lewis, CE
AF Gunderson, Erica P.
   Quesenberry, Charles P., Jr.
   Ning, Xian
   Jacobs, David R., Jr.
   Gross, Myron
   Goff, David C.
   Pletcher, Mark J.
   Lewis, Cora E.
TI Lactation Duration and Midlife Atherosclerosis
SO OBSTETRICS AND GYNECOLOGY
LA English
DT Article
ID ARTERY RISK DEVELOPMENT; BLOOD-PRESSURE; HYPERTENSIVE DISORDERS;
   YOUNG-ADULTS; FOLLOW-UP; PREGNANCY; WOMEN; PREDICTION; MOTHERS; STRESS
AB OBJECTIVE: To evaluate lactation duration in relation to subsequent atherosclerosis in women during midlife.
   METHODS: The Coronary Artery Risk Development in Young Adults study is a multicenter prospective cohort that enrolled 2,787 women in 1985-1986 (ages 18-30 years, 52% black, 48% white), of whom 2,014 (72%) attended the 20-year follow-up examination in 2005-2006. We selected 846 women (46% black) without heart disease or diabetes at baseline who delivered one or more times after the baseline evaluation, had cardiometabolic risk factors measured at baseline, and had maximum common carotid intima-media thickness (mm) measured at the 20-year follow-up examination in 2005-2006. Lactation duration was summed across all postbaseline births for each woman and (n, women) categorized as: 0 to less than 1 month (n=262), 1 to less than 6 months (n=210), 6 to less than 10 months (n=169), and 10 months or greater (n=205). Multiple linear regression models estimated mean common carotid intima-media thickness (95% confidence interval) and mean differences among lactation duration groups compared with the 0 to less than 1-month group adjusted for prepregnancy obesity, cardiometabolic status, parity, and other risk factors.
   RESULTS: Lactation duration had a graded inverse association with common carotid intima-media thickness; mean differences between 10 months or greater compared with 0 to less than 1 month ranged from -0.062 mm for unadjusted models (P trend <.001) to -0.029 mm for models fully adjusted for prepregnancy body mass index (BMI) and cardiometabolic risk factors, parity, smoking, and sociodemographics (P trend=.010). Stepwise addition of potential mediators (BMI, systolic blood pressure at the 20-year follow-up examination) modestly attenuated the lactation and common carotid intima-media thickness association to -0.027 and -0.023 mm (P trend=.019 and .054).
   CONCLUSION: Shorter lactation duration is associated with subclinical atherosclerosis independent of prepregnancy cardiometabolic risk factors and traditional risk factors. The magnitude of differences in carotid artery intima-media thickness may represent greater vascular aging. Lactation may have long-term benefits that lower cardiovascular disease risk in women.
C1 Kaiser Permanente No Calif, Div Res, Oakland, CA 94612 USA.
   Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA.
   Univ Minnesota, Sch Publ Hlth, Div Epidemiol & Community Hlth, Minneapolis, MN USA.
   Univ Colorado Denver, Colorado Sch Publ Hlth, Aurora, CO USA.
   Univ Alabama Birmingham, Div Prevent Med, Birmingham, AL USA.
C3 Kaiser Permanente; University of California System; University of
   California San Francisco; University of Minnesota System; University of
   Minnesota Twin Cities; Colorado School of Public Health; University of
   Colorado System; University of Colorado Anschutz Medical Campus;
   Children's Hospital Colorado; University of Alabama System; University
   of Alabama Birmingham
RP Gunderson, EP (corresponding author), Kaiser Permanente No Calif, Div Res, Cardiovasc & Metab Condit Sect, 2000 Broadway, Oakland, CA 94612 USA.
EM Erica.Gunderson@kp.org
RI Jacobs, David/G-5405-2011
OI Jacobs, David/0000-0002-7232-0543
FU National Heart, Lung and Blood Institute (NHLBI) [AG0005]; University of
   Alabama at Birmingham [HHSN268201300025C, HHSN268201300026C];
   Northwestern University [HHSN268201300027C]; University of Minnesota
   [HHSN268201300028C]; Kaiser Foundation Research Institute
   [HHSN268201300029C]; Johns Hopkins University School of Medicine
   [HHSN268200900041C]; Intramural Research Program of the National
   Institute on Aging (NIA); NIA; National Institute of Diabetes, Digestive
   and Kidney Diseases [K01 DK059944, R01 DK090047]
FX The Coronary Artery Risk Development in Young Adults (CARDIA) study is
   conducted and supported by the National Heart, Lung and Blood Institute
   (NHLBI) in collaboration with the University of Alabama at Birmingham
   (HHSN268201300025C and HHSN268201300026C), Northwestern University
   (HHSN268201300027C), University of Minnesota (HHSN268201300028C), Kaiser
   Foundation Research Institute (HHSN268201300029C), and Johns Hopkins
   University School of Medicine (HHSN268200900041C). CARDIA is also
   partially supported by the Intramural Research Program of the National
   Institute on Aging (NIA) and an intraagency agreement between NIA and
   NHLBI (AG0005). The analyses were supported by grants from K01 DK059944
   (Gunderson, Principal Investigator [PI]) and R01 DK090047 (Gunderson,
   PI) from the National Institute of Diabetes, Digestive and Kidney
   Diseases. This manuscript was reviewed by CARDIA for scientific content.
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NR 32
TC 48
Z9 53
U1 0
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0029-7844
J9 OBSTET GYNECOL
JI Obstet. Gynecol.
PD AUG
PY 2015
VL 126
IS 2
BP 381
EP 390
DI 10.1097/AOG.0000000000000919
PG 10
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA CN2WY
UT WOS:000358284500008
PM 26241429
OA Green Accepted, Green Submitted
DA 2025-06-11
ER

PT J
AU Rohner, M
   Heiz, R
   Feldhaus, S
   Bornstein, SR
AF Rohner, Markus
   Heiz, Robert
   Feldhaus, Simon
   Bornstein, Stefan R.
TI Hepatic-Metabolite-Based Intermittent Fasting Enables a Sustained
   Reduction in Insulin Resistance in Type 2 Diabetes and Metabolic
   Syndrome
SO HORMONE AND METABOLIC RESEARCH
LA English
DT Article
DE insulin resistance; diabetes remission; non-alcoholic fatty liver;
   weight loss resistance; epigenetics
ID HDL-CHOLESTEROL; ASSOCIATION; MELLITUS; PROFILE; TRIGLYCERIDES;
   PREVALENCE; GLUCOSE; HEALTH; ADULTS; RISK
AB Insulin resistance is the hallmark of Type 2 Diabetes and is still an unmet medical need. Insulin resistance lies at the crossroads of non-alcoholic fatty liver disease, obesity, weight loss and exercise resistance, heart disease, stroke, depression, and brain health. Insulin resistance is purely nutrition related, with a typical molecular disease food intake pattern. The insulin resistant state is accessible by TyG as the appropriate surrogate marker, which is found to lead the personalized molecular hepatic nutrition system for highly efficient insulin resistance remission. Treating insulin resistance with a molecular nutrition-centered approach shifts the treatment paradigm of Type 2 Diabetes from management to cure. This allows remission within five months, with a high efficiency rate of 85%. With molecular intermittent fasting a very efficient treatment for prediabetes and metabolic syndrome is possible, improving the non-alcoholic fatty liver disease (NAFL) state and enabling the body to lose weight in a sustainable manner.
C1 [Rohner, Markus] EGB EpiGeneticBalance AG, Rheinfelden, Switzerland.
   [Heiz, Robert] Zentrum Komplementarmed AG, Uster, Switzerland.
   [Feldhaus, Simon] Paramed AG, Haldenstr 1, Baar, Switzerland.
   [Bornstein, Stefan R.] Tech Univ Dresden, Dept Med, Fetscherstr 74, D-01307 Dresden, Germany.
C3 Technische Universitat Dresden
RP Bornstein, SR (corresponding author), Tech Univ Dresden, Dept Med, Fetscherstr 74, D-01307 Dresden, Germany.; Bornstein, SR (corresponding author), Tech Univ Dresden, Dev & Int Affairs, Fetscherstr 74, D-01307 Dresden, Germany.
EM stefan.bornstein@uniklinikum-dresden.de
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NR 87
TC 6
Z9 6
U1 0
U2 24
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0018-5043
EI 1439-4286
J9 HORM METAB RES
JI Horm. Metab. Res.
PD AUG
PY 2021
VL 53
IS 08
BP 529
EP 540
DI 10.1055/a-1510-8896
EA JUN 2021
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA TZ2ZL
UT WOS:000668312800001
PM 34192792
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Auryan, S
   Itamar, R
AF Auryan, Szalat
   Itamar, Raz
TI Gender-specific care of diabetes mellitus: particular considerations in
   the management of diabetic women
SO DIABETES OBESITY & METABOLISM
LA English
DT Review
DE cardiovascular risk factors; contraception; depression; diabetes
   mellitus; endothelial dysfunction; gestational diabetes mellitus;
   hormone replacement therapy; inflammation; macrovascular complications;
   metabolic syndrome; microvascular complications; osteoporosis;
   polycystic ovary syndrome; sex hormones; sex hormone receptors
ID CORONARY-HEART-DISEASE; POLYCYSTIC-OVARY-SYNDROME; POSTMENOPAUSAL
   HORMONE-THERAPY; IMPAIRED FASTING GLUCOSE; BONE-MINERAL DENSITY;
   ESTROGEN PLUS PROGESTIN; ENDOGENOUS SEX-HORMONES; C-REACTIVE PROTEIN;
   METABOLIC SYNDROME; RISK-FACTORS
AB In the past 30 years, the all-cause mortality and cardiovascular mortality rates for women with diabetes mellitus (DM), in contrast to men, have not declined. Furthermore, the difference between all-cause mortality rates in women with DM and those without DM has more than doubled. This urgently needs addressing. This review will analyse published medical literature relating to the specific management of DM in women and try to identify areas where gender affects care. We have identified specific gender differences in the pathophysiology of glucose homeostasis disorder, diabetes-related complications and any female gender-specific features of women with diabetes, such as contraception and the menopause. These gender-specific features of DM may offer a route to improved care for women and new therapeutic possibilities.
C1 [Auryan, Szalat] Hadassah Hebrew Univ Hosp, Dept Endocrinol & Metab, IL-91120 Jerusalem, Israel.
   [Itamar, Raz] Hadassah Hebrew Univ Hosp, Diabet Unit, IL-91120 Jerusalem, Israel.
C3 Hebrew University of Jerusalem; Hadassah University Medical Center;
   Hadassah University Hospital; Hebrew University of Jerusalem; Hadassah
   University Medical Center; Hadassah University Hospital
RP Auryan, S (corresponding author), Hadassah Hebrew Univ Hosp, Dept Endocrinol & Metab, IL-91120 Jerusalem, Israel.
EM auryans@hadassah.org.il
RI szalat, auryan/JNR-7010-2023
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NR 178
TC 58
Z9 67
U1 0
U2 10
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1462-8902
EI 1463-1326
J9 DIABETES OBES METAB
JI Diabetes Obes. Metab.
PD DEC
PY 2008
VL 10
IS 12
BP 1135
EP 1156
DI 10.1111/j.1463-1326.2008.00896.x
PG 22
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 367BU
UT WOS:000260528300001
PM 18494812
DA 2025-06-11
ER

PT J
AU Gill, J
   Luckenbaugh, D
   Charney, D
   Vythilingam, M
AF Gill, Jessica
   Luckenbaugh, David
   Charney, Dennis
   Vythilingam, Meena
TI Sustained Elevation of Serum Interleukin-6 and Relative Insensitivity to
   Hydrocortisone Differentiates Posttraumatic Stress Disorder with and
   Without Depression
SO BIOLOGICAL PSYCHIATRY
LA English
DT Article
DE Depression; glucocorticoid sensitivity; hydrocortisone; PTSD; serial
   sampling; serum IL-6
ID ENHANCED CORTISOL SUPPRESSION; CORONARY-ARTERY-DISEASE; PEPTIDASE-IV
   ACTIVITY; MAJOR DEPRESSION; DEXAMETHASONE-SUPPRESSION; ACTH RESPONSE;
   PSYCHOMETRIC PROPERTIES; MYOCARDIAL-INFARCTION; CYTOKINE PRODUCTION;
   METABOLIC SYNDROME
AB Background: Elevated levels of proinflammatory cytokines, especially interleukin-6 (IL-6), can mediate the greater risk for cardiovascular disease in individuals with posttraumatic stress disorder (PTSD), particularly in those with comorbid major depressive disorder (MDD). However, IL-6 levels are not consistently elevated in either PTSD or MDD. Although PTSD is associated with supersensitivity to glucocorticoids; prior studies have not evaluated the effect of comorbid MDD.
   Methods: Serum IL-6 levels were measured hourly between 7: 00 PM and 7: 00 AM in individuals with PTSD with comorbid MDD (PTSD + MDD) (n = 9) and compared with those with PTSD without MDD (PTSD - MDD) (n = 9) and nontraumatized healthy control subjects (n = 14). Group differences in serum IL-6, plasma adrenocorticotropic hormone (ACTH), and plasma cortisol response to 30 mg of intravenous hydrocortisone were evaluated using linear mixed models.
   Results: Only subjects with PTSD + MDD exhibited higher, overnight serum IL-6 levels compared with individuals with PTSD - MDD (p < .01) and healthy control subjects (p < .001). Peak overnight IL-6 levels positively correlated with severity of PTSD (r = .56, p < .01) and depressive symptoms (r = .54, p < .01). Hydrocortisone administration significantly reduced IL-6 levels in both PTSD groups; however, IL-6 levels in PTSD + MDD were higher than both PTSD - MDD (p < .05) and healthy control subjects (p < .01). Following hydrocortisone administration, there was a greater reduction in levels of ACTH in PTSD - MDD compared with control subjects (p < .01).
   Conclusions: Sustained elevations of overnight IL-6 levels and relatively decreased sensitivity to hydrocortisone distinguish PTSD + MDD from PTSD - MDD. Novel strategies that decrease IL-6 levels offer a new direction in the prevention and treatment of PTSD and associated comorbid medical illnesses.
C1 [Vythilingam, Meena] Off Assistant Secretary Def Hlth Affairs, Psychol Hlth Strateg Operat, Force Hlth Protect & Readiness, Falls Church, VA 22041 USA.
   [Gill, Jessica] NIMH, NINR, Bethesda, MD 20892 USA.
   [Luckenbaugh, David; Vythilingam, Meena] NIMH, Mood & Anxiety Disorders Program, Bethesda, MD 20892 USA.
   [Charney, Dennis] Mt Sinai Sch Med, New York, NY USA.
C3 National Institutes of Health (NIH) - USA; NIH National Institute of
   Nursing Research (NINR); NIH National Institute of Mental Health (NIMH);
   National Institutes of Health (NIH) - USA; NIH National Institute of
   Mental Health (NIMH); Icahn School of Medicine at Mount Sinai
RP Vythilingam, M (corresponding author), Off Assistant Secretary Def Hlth Affairs, Psychol Hlth Strateg Operat, Force Hlth Protect & Readiness, Skyline 4,Suite 800A,5113 Leesburg Pike, Falls Church, VA 22041 USA.
EM meena.vythilingam@ha.osd.mil
RI Gill, Gill/Q-2020-2017
FU National Institute of Mental Health Intramural Research Program
FX The research reported in this manuscript was undertaken at the National
   Institutes of Health and funded by the National Institute of Mental
   Health Intramural Research Program.
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NR 77
TC 69
Z9 74
U1 0
U2 14
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
EI 1873-2402
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD DEC 1
PY 2010
VL 68
IS 11
BP 999
EP 1006
DI 10.1016/j.biopsych.2010.07.033
PG 8
WC Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Psychiatry
GA 688FG
UT WOS:000284834600007
PM 20951370
DA 2025-06-11
ER

PT J
AU Antunes, LD
   da Jornada, MN
   Ramalho, L
   Hidalgo, MPL
AF Antunes, Luciana da Conceicao
   da Jornada, Manoela Neves
   Ramalho, Leticia
   Loayza Hidalgo, Maria Paz
TI Correlation of shift work and waist circumference, body mass index,
   chronotype and depressive symptoms
SO ARQUIVOS BRASILEIROS DE ENDOCRINOLOGIA E METABOLOGIA
LA English
DT Article
DE Shift work; sleep-wake cycle; waist circumference; depressive symptoms;
   chronotype
ID METABOLIC SYNDROME; SLEEP; GLUCOSE; LEPTIN; MOOD; RISK
AB Objective: Correlate shift work with body mass index (BMI), waist circumference, chronotype and depressive symptoms. Subjects and methods:This study comprising 14 shift workers and 13 day workers. Subjects were workers from the health area aged 25 to 60 years. Minor psychiatric disorders were accessed by Self Report Questionnaire (SRQ-20) and depressive symptoms by Beck Depression Inventory (BDI). Chronotype was accessed using Morningness-Eveningness Questionnaire (MEQ). Anthropometric measures were taken. Results: Shift workers presented higher BMI (P = 0.03) and waist circumference (P = 0.004) than day workers. Years on shift work were significantly correlated to waist circumference (r = 0.43; P = 0.03) and age (r = 0.47; P = 0.02). Shift work was not correlated with depressive symptoms and chronotype. Conclusion: These results may suggest a role played by shift work on the development and/or the early clinic manifestations of metabolic disturbances, becoming a risk factor to metabolic syndrome. Arq Bras Endocrinol Metab. 2010;54(7):652-6
C1 [Antunes, Luciana da Conceicao] Univ Fed Rio Grande do Sul, Fac Med, Sch Med, Postgraduat Program Med Sci, BR-90035003 Porto Alegre, RS, Brazil.
   [Loayza Hidalgo, Maria Paz] Univ Fed Rio Grande do Sul, Clin Hosp Porto Alegre HCPA, Human Chronobiol Program, Psychiat & Legal Med Dept,Med Sch, BR-90035003 Porto Alegre, RS, Brazil.
C3 Universidade Federal do Rio Grande do Sul; Universidade Federal do Rio
   Grande do Sul
RP Antunes, LD (corresponding author), Univ Fed Rio Grande do Sul, Fac Med, Sch Med, Postgraduat Program Med Sci, Rua Ramiro Barcelos 2400,2 Andar, BR-90035003 Porto Alegre, RS, Brazil.
EM lc-antunes@hotmail.com
RI Antunes, Luciana/GQZ-3088-2022; C. Antunes, Luciana/F-1732-2015
OI C. Antunes, Luciana/0000-0002-0106-0721; Hidalgo, Maria
   Paz/0000-0002-7886-770X
FU Fundo de Incentivo a Pesquisa e Eventos (FIPE) at Hospital de Clinicas
   de Porto Alegre, Brazil
FX This work was supported by Fundo de Incentivo a Pesquisa e Eventos
   (FIPE) at Hospital de Clinicas de Porto Alegre, Brazil.
CR [Anonymous], JAMA
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NR 31
TC 33
Z9 36
U1 0
U2 9
PU SBEM-SOC BRASIL ENDOCRINOLOGIA & METABOLOGIA
PI RIO DE JANEIRO, RJ
PA RUA HUMAITA, 85 CJ 501, RIO DE JANEIRO, RJ, 22261-000, BRAZIL
SN 0004-2730
J9 ARQ BRAS ENDOCRINOL
JI Arq. Bras. Endocrinol. Metabol.
PD OCT
PY 2010
VL 54
IS 7
BP 652
EP 656
DI 10.1590/S0004-27302010000700010
PG 5
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 677YL
UT WOS:000284032800010
PM 21085771
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Ono, R
   Yamazaki, S
   Takegami, M
   Otani, K
   Sekiguchi, M
   Onishi, Y
   Hayashino, Y
   Kikuchi, S
   Konno, S
   Fukuhara, S
AF Ono, Rei
   Yamazaki, Shin
   Takegami, Misa
   Otani, Koji
   Sekiguchi, Miho
   Onishi, Yoshihiro
   Hayashino, Yasuaki
   Kikuchi, Shin-ichi
   Konno, Shin-ichi
   Fukuhara, Shunichi
TI Gender Difference in Association Between Low Back Pain and Metabolic
   Syndrome Locomotive Syndrome and Health Outcome in Aizu Cohort
   Study (LOHAS)
SO SPINE
LA English
DT Article
DE low back pain; metabolic syndrome; community-based subject; prevalence
ID GENERAL JAPANESE POPULATION; 3RD NATIONAL-HEALTH;
   CARDIOVASCULAR-DISEASE; PHYSICAL-ACTIVITY; BLOOD-PRESSURE; NECK PAIN;
   PREVALENCE; LIFE; MENOPAUSE; MORTALITY
AB Study Design. Cross-sectional survey.
   Objective. To investigate the relationship between low back pain (LBP) and metabolic syndrome (Mets) in community-based Japanese subjects.
   Summary of Background Data. Relatively few reports have demonstrated a relationship between general pain and Mets, and none have addressed the relationship between LBP and Mets.
   Methods. This study enrolled 2650 people from among residents aged 40 to 74 years in Tadami and Minamiaizu, Fukushima, Japan, who participated in health checkups conducted in 2008. LBP was defined as lower back pain continuing for more than 24 hours and severe enough to merit treatment, or it was based on clinical prediction rules from the clinical diagnosis support tool to identify patients with lumbar spinal stenosis. Mets was defined according to the Japanese criteria recommended by the Japanese Society of Internal Medicine. Prevalence of Mets was recorded for subjects with and without LBP. The relationship between LBP and Mets was investigated, using a generalized linear model. With LBP as the main explanatory variable and Mets as the outcome variable, risk ratios of Mets were calculated for men and women.
   Results. In this study, we analyzed a total of 1395 subjects. In men, the prevalence of Mets was 21.2% in those without LBP and 24.7% in those with LBP. In women, the prevalence of Mets was 12.4% in those without LBP and 23.7% in those with LBP. After adjusting for factors such as age, body mass index, occupational status, SF-36 mental health, and physical activity level, no relationship was noted between LBP and Mets in men. However, in women, the risk ratio for Mets in subjects with LBP compared with those without LBP was 1.5 (95% confidence interval, 1.0-2.1).
   Conclusion. We observed a tendency toward higher prevalence of Mets among those with LBP than among those without it in women, but not in men.
C1 [Ono, Rei] Kobe Univ, Grad Sch Hlth Sci, Dept Community Hlth Sci, Suma Ku, Kobe, Hyogo 6540142, Japan.
   [Ono, Rei; Yamazaki, Shin; Takegami, Misa; Hayashino, Yasuaki; Fukuhara, Shunichi] Kyoto Univ, Grad Sch Med & Publ Hlth, Dept Epidemiol & Hlth Care Res, Kyoto, Japan.
   [Yamazaki, Shin; Onishi, Yoshihiro; Fukuhara, Shunichi] Inst Hlth Outcomes & Proc Evaluat Res, Kyoto, Japan.
   [Otani, Koji; Sekiguchi, Miho; Kikuchi, Shin-ichi; Konno, Shin-ichi] Fukushima Med Univ, Sch Med, Dept Orthoped Surg, Fukushima, Japan.
   [Takegami, Misa] Natl Cerebral & Cardiovasc Ctr, Dept Prevalence Med & Epidemiol Informat, Osaka, Japan.
C3 Kobe University; Kyoto University; Fukushima Medical University;
   National Cerebral & Cardiovascular Center - Japan
RP Ono, R (corresponding author), Kobe Univ, Grad Sch Hlth Sci, Dept Community Hlth Sci, Suma Ku, 7-10-2 Tomogaoka, Kobe, Hyogo 6540142, Japan.
EM ono@phoenix.kobe-u.ac.jp
RI Hayashino, Yasuaki/AAA-8637-2022; Yamazaki, Shin-ichi/H-8089-2018;
   Otani, Koji/ABF-8564-2020
OI ONO, Rei/0000-0002-0176-2870; Otani, Koji/0000-0001-8409-9623;
   Hayashino, Yasuaki/0000-0002-2932-8478
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NR 37
TC 22
Z9 23
U1 1
U2 15
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0362-2436
EI 1528-1159
J9 SPINE
JI SPINE
PD JUN 1
PY 2012
VL 37
IS 13
BP 1130
EP 1137
DI 10.1097/BRS.0b013e31824231b8
PG 8
WC Clinical Neurology; Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Orthopedics
GA 952CF
UT WOS:000304766600014
PM 22146290
DA 2025-06-11
ER

PT J
AU Vlachakis, C
   Dragoumani, K
   Raftopoulou, S
   Mantaiou, M
   Papageorgiou, L
   Tsaniras, SC
   Megalooikonomou, V
   Vlachakis, D
AF Vlachakis, Chrisanthy
   Dragoumani, Konstantina
   Raftopoulou, Sofia
   Mantaiou, Meropi
   Papageorgiou, Louis
   Tsaniras, Spyridon Champeris
   Megalooikonomou, Vasileios
   Vlachakis, Dimitrios
TI Human Emotions on the Onset of Cardiovascular and Small Vessel Related
   Diseases
SO IN VIVO
LA English
DT Article
DE Emotional intelligence; emotions; coronary heart disease; diabetes
   melitus; obesity
ID CORONARY-HEART-DISEASE; QUALITY-OF-LIFE; TYPE-2 DIABETIC-PATIENTS; EDID
   RESEARCH CONSORTIUM; POOR GLYCEMIC CONTROL; RISK-FACTORS; DEPRESSIVE
   SYMPTOMS; METABOLIC SYNDROME; POSITIVE EMOTIONS; SOCIOECONOMIC-STATUS
AB Background/Aim: The aim of the present study was to examine the relation between understanding of emotions and cardiovascular related diseases, namely coronary heart disease, diabetes mellitus and obesity. The uniqueness of this study lies in the fact that it examined the relationship between the cardiovascular related diseases named above and the understanding of emotions in the context of Emotional Intelligence (EI). Patients and Methods: The study was conducted in 300 participants during a 3 year period. All participants completed a self-report questionnaire, assessing various aspects of EI, such as self-emotion appraisal, other emotion appraisal, emotion regulation and use of emotions. As hypothesized, coronary heart disease is a prognostic factor of regulation of emotions. Results: The present study is an attempt to examine the relation between emotional understanding and cardiovascular related diseases, namely coronary heart disease, diabetes mellitus and obesity. Establishing which diseases are independent risk factors for the understanding of emotions, could have a significant impact on emotional health, through the treatment of these cardiovascular related diseases. Emotions were studied within the theoretical context of Emotional Intelligence (EI), which affects people's physical and mental health. Conclusion: The results of this study emphasize on the relationship of cardiovascular related diseases and psychological characteristics, such as anxiety and anger, being aspects of EI. Additionally, this work fills a gap in the relevant Greek literature, as a first attempt to examine the correlation of EI with cardiovascular related diseases.
C1 [Vlachakis, Chrisanthy; Dragoumani, Konstantina; Raftopoulou, Sofia; Papageorgiou, Louis; Vlachakis, Dimitrios] Agr Univ Athens, Sch Food Biotechnol & Dev, Dept Biotechnol, Lab Genet, Athens, Greece.
   [Raftopoulou, Sofia; Mantaiou, Meropi] Sotiria Chest Dis Hosp, Athens, Greece.
   [Raftopoulou, Sofia; Vlachakis, Dimitrios] Acad Athens, Biomed Res Fdn, Ctr Clin Expt Surg & Translat Res, Div Endocrinol & Metab, Athens, Greece.
   [Papageorgiou, Louis] Natl & Kapodistrian Univ Athens, Dept Informat & Telecommun, Univ Campus, Athens, Greece.
   [Tsaniras, Spyridon Champeris] Univ Patras, Med Sch, Dept Physiol, Patras, Greece.
   [Megalooikonomou, Vasileios; Vlachakis, Dimitrios] Univ Patras, Sch Engn, Comp Engn & Informat Dept, Patras, Greece.
C3 Agricultural University of Athens; Academy of Athens; National &
   Kapodistrian University of Athens; University of Patras; University of
   Patras
RP Vlachakis, D (corresponding author), Agr Univ Athens, Sch Food Biotechnol & Dev, Dept Biotechnol, Lab Genet, Athens, Greece.
EM dimvl@aua.gr
RI DRAGOUMANI, KONSTANTINA/GWU-6137-2022; Vlachakis, Dimitrios/O-4323-2018;
   Champeris Tsaniras, Spyridon/F-1187-2014
OI Vlachakis, Dimitrios/0000-0003-1823-6102; Papageorgiou,
   Louis/0000-0001-9577-9923; Champeris Tsaniras,
   Spyridon/0000-0002-4960-9314; Dragoumani,
   Konstantina/0009-0001-8388-6964
FU FrailSafe Project [H2020-PHC-21-2015-690140]; European Commission under
   the Horizon 2020 research and innovation programme
FX The research reported in the present paper was partially supported by
   the FrailSafe Project (H2020-PHC-21-2015-690140) "Sensing and predictive
   treatment of frailty and associated co-morbidities using advanced
   personalized models and advanced interventions", co-funded by the
   European Commission under the Horizon 2020 research and innovation
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NR 134
TC 9
Z9 13
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U2 12
PU INT INST ANTICANCER RESEARCH
PI ATHENS
PA EDITORIAL OFFICE 1ST KM KAPANDRITIOU-KALAMOU RD KAPANDRITI, PO BOX 22,
   ATHENS 19014, GREECE
SN 0258-851X
EI 1791-7549
J9 IN VIVO
JI In Vivo
PD JUL-AUG
PY 2018
VL 32
IS 4
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EP 870
DI 10.21873/invivo.11320
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WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Research & Experimental Medicine
GA GK5RJ
UT WOS:000436233800023
PM 29936471
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Santoro, N
   Torrens, J
   Crawford, S
   Allsworth, JE
   Finkelstein, JS
   Gold, EB
   Korenman, S
   Lasley, WL
   Luborsky, JL
   McConnell, D
   Sowers, MF
   Weiss, G
AF Santoro, N
   Torrens, J
   Crawford, S
   Allsworth, JE
   Finkelstein, JS
   Gold, EB
   Korenman, S
   Lasley, WL
   Luborsky, JL
   McConnell, D
   Sowers, MF
   Weiss, G
TI Correlates of circulating androgens in mid-life women: The study of
   women's health across the nation
SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Article
ID DEHYDROEPIANDROSTERONE-SULFATE; PERIMENOPAUSAL WOMEN;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; BODY-COMPOSITION; SEXUAL
   FUNCTION; SURVEY SF-36; TESTOSTERONE; MENOPAUSE; HORMONES
AB Context: Androgens influence sexual differentiation and behavior, body composition, and physical functioning in men, but their role in women is less well understood. Because circulating androgens decline with age, the use of androgen supplementation for women to improve health and well-being has been increasing.
   Objective: The aim of this study was to assess the association between androgens and a variety of end points thought to be affected by androgens.
   Design: In a community-based baseline cohort of women aged 42-52 yr from the Study of Women's Health Across the Nation, we measured circulating testosterone (T), dehydroepiandrosterone sulfate, and SHBG, and calculated a free androgen index (FAI) in 2961 women.
   Main Outcome Measures: Correlations of androgen measures with each other and with body mass index, waist circumference, and waist-hip ratio were computed, and odds ratios (OR) were estimated for the categorical outcomes of functional limitations, functional status, self-reported health, scores indicative of depressed mood, quality of life, sexual desire and arousal, and the presence of the metabolic syndrome.
   Results: Androgens, and particularly SHBG, were associated most strongly with body mass index, waist circumference, and waist-hip ratio. SHBG was associated prominently inversely with the metabolic syndrome (OR = 0.32; 95% confidence interval = 0.26-0.39), which was present in 17% of women at baseline. Dehydroepiandrosterone sulfate was associated modestly with functional status and self-reported health. T was associated minimally with increased sexual desire (OR = 1.09; 95% confidence interval = 1.00-1.18). The association of FAI with self-reported health and depressive symptomatology based on the Center for Epidemiologic Studies Depression Scale score was explained more by T than by SHBG, whereas the association of FAI with sexual arousal and metabolic syndrome was due more to SHBG than to T.
   Conclusions: Circulating SHBG and androgens are most strongly associated with physical characteristics and the metabolic syndrome in women in this community-based cohort. Androgens are related weakly to physical functioning and other symptoms to which they commonly are attributed, such as sexual desire, sexual arousal, and well-being.
C1 Albert Einstein Coll Med, Dept Obstet Gynecol & Womens Hlth, Div Reprod Endocrinol, Bronx, NY 10461 USA.
   Massachusetts Gen Hosp, Boston, MA 02114 USA.
   Rush Univ, Rush Presbyterian St Lukes Med Ctr, Chicago, IL 60612 USA.
   Univ Calif Davis, Davis, CA 95616 USA.
   Univ Calif Los Angeles, Los Angeles, CA 90095 USA.
   Univ Med & Dent New Jersey, New Jersey Med Sch, Newark, NJ 07103 USA.
   Univ Michigan, Ann Arbor, MI 48104 USA.
   New England Res Inst, Watertown, MA 02472 USA.
C3 Montefiore Medical Center; Albert Einstein College of Medicine; Yeshiva
   University; Harvard University; Harvard University Medical Affiliates;
   Massachusetts General Hospital; Rush University; University of
   California System; University of California Davis; University of
   California System; University of California Los Angeles; Rutgers
   University System; Rutgers University New Brunswick; Rutgers University
   Biomedical & Health Sciences; University of Michigan System; University
   of Michigan; HealthCore, Inc
RP Albert Einstein Coll Med, Dept Obstet Gynecol & Womens Hlth, Div Reprod Endocrinol, 1300 Morris Pk Ave,Mazer 316, Bronx, NY 10461 USA.
EM glicktoro@aol.com
RI Finkelstein, Joel/M-6463-2019; Allsworth, Jenifer/J-2475-2019
OI Allsworth, Jenifer/0000-0001-6559-8638
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U1 0
U2 9
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0021-972X
EI 1945-7197
J9 J CLIN ENDOCR METAB
JI J. Clin. Endocrinol. Metab.
PD AUG
PY 2005
VL 90
IS 8
BP 4836
EP 4845
DI 10.1210/jc.2004-2063
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism
GA 953HZ
UT WOS:000231068500061
PM 15840738
OA Bronze
DA 2025-06-11
ER

PT J
AU Marquine, MJ
   Gallo, LC
   Tarraf, W
   Wu, BS
   Moore, AA
   Vásquez, PM
   Talavera, G
   Allison, M
   Muñoz, E
   Isasi, CR
   Perreira, KM
   Bigornia, SJ
   Daviglus, M
   Estrella, ML
   Zeng, DL
   González, HM
AF Marquine, Maria J.
   Gallo, Linda C.
   Tarraf, Wassim
   Wu, Benson
   Moore, Alison A.
   Vasquez, Priscilla M.
   Talavera, Gregory
   Allison, Matthew
   Munoz, Elizabeth
   Isasi, Carmen R.
   Perreira, Krista M.
   Bigornia, Sherman J.
   Daviglus, Martha
   Estrella, Mayra L.
   Zeng, Donglin
   Gonzalez, Hector M.
TI The Association of Stress, Metabolic Syndrome, and Systemic Inflammation
   With Neurocognitive Function in the Hispanic Community Health
   Study/Study of Latinos and Its Sociocultural Ancillary Study
SO JOURNALS OF GERONTOLOGY SERIES B-PSYCHOLOGICAL SCIENCES AND SOCIAL
   SCIENCES
LA English
DT Article
DE Cardiovascular disease; Cognition; Minority and diverse populations
ID CARDIOVASCULAR-DISEASE; COGNITIVE FUNCTION; TRAUMATIC STRESS;
   RISK-FACTOR; PREVALENCE; DESIGN; ADULTS
AB Objectives Identifying sociocultural correlates of neurocognitive dysfunction among Hispanics/Latinos, and their underlying biological pathways, is crucial for understanding disparities in Alzheimer's disease and related dementias. We examined cross-sectional associations between stress and neurocognition, and the role that metabolic syndrome (MetS) and systemic inflammation might play in these associations. Method Participants included 3,045 adults aged 45-75 (56% female, education 0-20+ years, 86% Spanish-speaking, 23% U.S.-born), enrolled in the Hispanic Community Health Study/Study of Latinos and its Sociocultural Ancillary Study. Global neurocognition was the primary outcome and operationalized as the average of the z scores of measures of learning and memory, word fluency, and processing speed. Stress measures included self-report assessments of stress appraisal (perceived and acculturative stress) and exposure to chronic and traumatic stressors. MetS was defined via established criteria including waist circumference, high blood pressure, elevated triglycerides, fasting plasma glucose, and high levels of high-density lipoprotein cholesterol. Systemic inflammation was represented by high-sensitivity C-reactive protein (hs-CRP). Results Separate survey multivariable linear regression models adjusting for covariates showed that higher perceived (b = -0.004, SE = 0.002, p < .05) and acculturative stress (b = -0.004, SE = 0.001, p < .0001) were significantly associated with worse global neurocognition, while lifetime exposure to traumatic stressors was associated with better global neurocognition (b = 0.034, SE = 0.009, p < .001). Neither MetS nor hs-CRP were notable pathways in the association between stress and neurocognition; rather, they were both independently associated with worse neurocognition in models including stress measures (ps < .05). Discussion These cross-sectional analyses suggest that stress appraisal, MetS, and systemic inflammation may be targets to reduce neurocognitive dysfunction among Hispanics/Latinos.
C1 [Marquine, Maria J.; Moore, Alison A.] Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA.
   [Marquine, Maria J.] Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA.
   [Gallo, Linda C.; Talavera, Gregory] San Diego State Univ, Dept Psychol, San Diego, CA 92182 USA.
   [Tarraf, Wassim] Wayne State Univ, Inst Gerontol, Dept Healthcare Sci, Detroit, MI 48202 USA.
   [Wu, Benson; Gonzalez, Hector M.] Univ Calif San Diego, Dept Neurosci, La Jolla, CA 92093 USA.
   [Vasquez, Priscilla M.] Charles R Drew Univ Med & Sci, Dept Urban Publ Hlth, 1621 E 120th St, Los Angeles, CA 90059 USA.
   [Allison, Matthew] Univ Calif San Diego, Dept Family Med, La Jolla, CA 92093 USA.
   [Munoz, Elizabeth] Univ Texas Austin, Dept Human Dev & Family Sci, Austin, TX 78712 USA.
   [Isasi, Carmen R.] Albert Einstein Coll Med, Dept Epidemiol & Populat Hlth, Bronx, NY 10467 USA.
   [Perreira, Krista M.] Univ N Carolina, Dept Social Med, Chapel Hill, NC 27515 USA.
   [Bigornia, Sherman J.] Univ New Hampshire, Dept Agr Nutr & Food Syst, Durham, NH 03824 USA.
   [Daviglus, Martha; Estrella, Mayra L.] Univ Illinois, Inst Minor Hlth Res, Chicago, IL USA.
   [Zeng, Donglin] Univ N Carolina, Dept Biostat, Chapel Hill, NC 27515 USA.
C3 University of California System; University of California San Diego;
   University of California System; University of California San Diego;
   California State University System; San Diego State University; Wayne
   State University; University of California System; University of
   California San Diego; Charles R. Drew University of Medicine & Science;
   University of California System; University of California San Diego;
   University of Texas System; University of Texas Austin; Montefiore
   Medical Center; Albert Einstein College of Medicine; Yeshiva University;
   University of North Carolina; University of North Carolina Chapel Hill;
   University System Of New Hampshire; University of New Hampshire;
   University of Illinois System; University of Illinois Chicago;
   University of Illinois Chicago Hospital; University of North Carolina;
   University of North Carolina Chapel Hill
RP Marquine, MJ (corresponding author), Univ Calif San Diego, Dept Med, Div Geriatr Gerontol & Palliat Care, 9500 Gilman Dr 0665, La Jolla, CA 92093 USA.
EM mmarquine@health.ucsd.edu
RI Gonzalez, Hector/AAV-7576-2021; Xu, Tianchen/AAR-4013-2021; Munoz,
   Elizabeth/F-4247-2018
OI Perreira, Krista/0000-0003-2906-0261; Munoz,
   Elizabeth/0000-0003-2152-5917; Marquine, Maria/0000-0003-2249-6628
FU National Heart, Lung, and Blood Institute
   [HHSN268201300001I/N01-HC-65233, HHSN26820 1300004I/N01-HC-65234,
   HHSN268201300002I/N01-HC-65235, HHSN268201300003I/N01-HC-65236,
   HHSN268201300005I/N01-HC-65237]; National Institute on Minority Health
   and Health Disparities; National Institute on Deafness and Other
   Communication Disorders; National Institute of Dental and Craniofacial
   Research; National Institute of Diabetes and Digestive and Kidney
   Diseases; National Institute of Neurological Disorders and Stroke;
   National Institutes of Health (NIH) Office of Dietary Supplements; NIH
   [R01AG048642, RF1AG054548, P30AG059299, DK111022-8786, P30AG062429]; 
   [RC2HL101649]; Eunice Kennedy Shriver National Institute of Child Health
   and Human Development [P2CHD050924] Funding Source: NIH RePORTER
FX The Hispanic Community Health Study/Study of Latinos is a collaborative
   study supported by contracts from the National Heart, Lung, and Blood
   Institute to the University of North Carolina
   (HHSN268201300001I/N01-HC-65233), University of Miami (HHSN26820
   1300004I/N01-HC-65234), Albert Einstein College of Medicine
   (HHSN268201300002I/N01-HC-65235), University of Illinois at Chicago
   (HHSN268201300003I/N01-HC-65236 Northwestern University), and San Diego
   State University (HHSN268201300005I/N01-HC-65237). The following
   institutes/centers/offices have contributed to the HCHS/SOL through a
   transfer of funds to the National Heart, Lung, and Blood Institute:
   National Institute on Minority Health and Health Disparities, National
   Institute on Deafness and Other Communication Disorders, National
   Institute of Dental and Craniofacial Research, National Institute of
   Diabetes and Digestive and Kidney Diseases, National Institute of
   Neurological Disorders and Stroke, and National Institutes of Health
   (NIH) Office of Dietary Supplements. The HCHS/SOL Socio-Cultural
   Ancillary Study was supported by grant number RC2HL101649. This work was
   also supported by the following NIH grants: R01AG048642, RF1AG054548,
   P30AG059299, DK111022-8786, and P30AG062429.
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NR 50
TC 7
Z9 7
U1 1
U2 12
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1079-5014
EI 1758-5368
J9 J GERONTOL B-PSYCHOL
JI J. Gerontol. Ser. B-Psychol. Sci. Soc. Sci.
PD MAY 5
PY 2022
VL 77
IS 5
BP 860
EP 871
DI 10.1093/geronb/gbab150
EA OCT 2021
PG 12
WC Geriatrics & Gerontology; Gerontology; Psychology; Psychology,
   Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Psychology
GA 1A1EJ
UT WOS:000756473300001
PM 34378777
OA Green Published
DA 2025-06-11
ER

PT J
AU Lee, DE
   Clark, AK
   Shi, VY
AF Lee, Dylan E.
   Clark, Ashley K.
   Shi, Vivian Y.
TI Hidradenitis Suppurativa: Disease Burden and Etiology in Skin of Color
SO DERMATOLOGY
LA English
DT Review
DE Hidradenitis suppurativa; Disease burden; Skin of color
ID METABOLIC SYNDROME; UNITED-STATES; SOCIOECONOMIC-STATUS;
   AFRICAN-AMERICANS; RANDOMIZED-TRIAL; CHINESE FAMILY; ACNE INVERSA;
   DOUBLE-BLIND; ADALIMUMAB; HEALTH
AB Hidradenitis suppurativa (HS) is a chronic, debilitating skin disease. Although most studies on HS are conducted in largely Caucasian populations, evidence demonstrates a higher prevalence in patients with skin of color, including African and Hispanic populations. These racial subgroups are likely at risk for greater disease burden due to a higher prevalence of components of the metabolic syndrome, comorbid depression, and low socioeconomic status; however, there is a paucity of research in these populations. Additionally, studies examining the genetic and anatomical basis for HS, as well as the response to HS therapies, are lacking for patients with skin of color. Complicating this issue is the limited access to effective medical care, including dermatologists, for African and Hispanic populations as well as other minority groups. In this review, we identify gaps in the knowledge base, highlight the association between HS and patients with skin of color, and provide direction for much needed research into this condition. (C) 2018 S. Karger AG, Basel
C1 [Lee, Dylan E.] Creighton Univ, Sch Med, Omaha, NE USA.
   [Clark, Ashley K.] Univ Calif Davis, Sch Med, Sacramento, CA 95817 USA.
   [Shi, Vivian Y.] Univ Arizona, Dept Med, Div Dermatol, 1515 N Campbell Ave,POB 245024,Bldg 222,Levy Bldg, Tucson, AZ 85724 USA.
C3 Creighton University; University of California System; University of
   California Davis; University of Arizona
RP Shi, VY (corresponding author), Univ Arizona, Dept Med, Div Dermatol, 1515 N Campbell Ave,POB 245024,Bldg 222,Levy Bldg, Tucson, AZ 85724 USA.
EM vshi@email.arizona.edu
OI Shi, Vivian/0000-0002-7510-9428
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NR 47
TC 51
Z9 51
U1 0
U2 3
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1018-8665
EI 1421-9832
J9 DERMATOLOGY
JI Dermatology
PY 2017
VL 233
IS 6
BP 456
EP 461
DI 10.1159/000486741
PG 6
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology
GA GD4XE
UT WOS:000430505800007
PM 29495009
OA Bronze
DA 2025-06-11
ER

PT J
AU Modi, K
   Singh, I
   Kumar, Y
AF Modi, Krishna
   Singh, Ishbir
   Kumar, Yogesh
TI A Comprehensive Analysis of Artificial Intelligence Techniques for the
   Prediction and Prognosis of Lifestyle Diseases
SO ARCHIVES OF COMPUTATIONAL METHODS IN ENGINEERING
LA English
DT Review
ID METABOLIC SYNDROME; MACHINE; ASTHMA
AB Artificial intelligence is the fastest growing data-driven technology and is currently used in all major fields and reduces the work of humans. Artificial intelligence can analyse extensive data from Electronic Health Records, clinical trials, patient's medical history, X-rays, CT scans and contribute to the healthcare field by explicitly detecting and predicting lifestyle diseases such as Alzheimer, Arthritis, Asthma, Atherosclerosis, COPD, Depression, Obesity, Osteoporosis, Metabolic Syndrome and PCOS. Lifestyle diseases are diseases related to the daily habits or routines of individuals such as smoking, excessive consumption of alcohol, physical inactivity, overeating etc. Common techniques used by AI to diagnose these diseases are Decision Tree, Random Forest, ANN, SVM, Regression, Naive Bayes and deep learning models such as Convolutional Neural Network, Recurrent Neural Network, and Natural Language Processing. A common framework is presented in this paper to carry forward the research to add significant value. This paper presents an extensive overview of the diseases, their symptoms and associated illnesses, risk factors, datasets suitable for developing predictive models, challenges encountered by researchers, and significant contributions made in this area.
C1 [Modi, Krishna] Indus Univ, Indus Inst Technol & Engn, Dept CSE, Ahmadabad 382115, India.
   [Singh, Ishbir] Indus Univ, Indus Inst Technol & Engn, Dept ME, Ahmadabad 382115, India.
   [Kumar, Yogesh] Pandit Deendayal Energy Univ, Sch Technol, Dept CSE, Gandhinagar, Gujarat, India.
C3 Pandit Deendayal Energy University
RP Kumar, Y (corresponding author), Pandit Deendayal Energy Univ, Sch Technol, Dept CSE, Gandhinagar, Gujarat, India.
EM krishnamodi1994@gmail.com; ishbir@rediffmail.com;
   yogesh.arora10744@gmail.com
RI Modi, Krishna/LKK-6786-2024; kumar, yogesh/AAD-8469-2021
OI Modi, Krishna/0000-0001-9840-5919; kumar, yogesh/0000-0002-2879-0441
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NR 85
TC 12
Z9 12
U1 4
U2 27
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1134-3060
EI 1886-1784
J9 ARCH COMPUT METHOD E
JI Arch. Comput. Method Eng.
PD NOV
PY 2023
VL 30
IS 8
BP 4733
EP 4756
DI 10.1007/s11831-023-09957-2
EA JUN 2023
PG 24
WC Computer Science, Interdisciplinary Applications; Engineering,
   Multidisciplinary; Mathematics, Interdisciplinary Applications
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Computer Science; Engineering; Mathematics
GA U7EJ1
UT WOS:001016161300001
DA 2025-06-11
ER

PT J
AU Maksimovic, M
   Vlajinac, H
   Radak, D
   Marinkovic, J
   Jorga, J
AF Maksimovic, Milos
   Vlajinac, Hristina
   Radak, Djordje
   Marinkovic, Jelena
   Jorga, Jagoda
TI Relationship Between High-Sensitivity C-Reactive Protein and Risk
   Factors in Patients With Peripheral Arterial Disease-A Cross-Sectional
   Study
SO ANGIOLOGY
LA English
DT Article
DE high-sensitivity C-reactive protein; peripheral arterial disease; risk
   factors
ID CARDIOVASCULAR-DISEASE; URIC-ACID; METABOLIC SYNDROME;
   MYOCARDIAL-INFARCTION; INFLAMMATORY MARKERS; INSULIN-RESISTANCE;
   VASCULAR-DISEASE; ATHEROSCLEROSIS; WOMEN; ASSOCIATION
AB We investigated whether patients with peripheral arterial disease (PAD) with various serum levels of high-sensitivity C-reactive protein (hsCRP) differ in the frequency of atherosclerotic risk factors. Among 388 patients, hsCRP levels were (1) low, <1 mg/L, in 41 (10.6%) participants; (2) medium, from 1 to 3 mg/L, in 152 (39.2%) participants, and (3) high, >3 mg/L, in 195 (50.2%) individuals. According to multivariate logistic regression analysis, in comparison with patients with hsCRP level <= 3.0 mg/L, those with higher hsCRP levels had more frequently a severe form of PAD(gangrene, P ranged from. 045 to <.001; ankle-brachial index <=.40, P = .059) and had more frequently some of atherosclerotic risk factors (metabolic syndrome, P = .007; hypertension, P = .013; abdominal obesity, P = .007; high levels of uric acid, P = .022; high level of fibrinogen, P <.001; and depression, P = .015).
C1 [Maksimovic, Milos; Jorga, Jagoda] Univ Belgrade, Inst Hyg & Med Ecol, Fac Med, Belgrade 11001, Serbia.
   [Vlajinac, Hristina] Univ Belgrade, Inst Epidemiol, Fac Med, Belgrade 11001, Serbia.
   [Radak, Djordje] Univ Belgrade, Dept Vasc Surg, Fac Med, Dedinje Cardiovasc Inst, Belgrade 11001, Serbia.
   [Marinkovic, Jelena] Univ Belgrade, Inst Med Stat & Informat, Fac Med, Belgrade 11001, Serbia.
C3 University of Belgrade; University of Belgrade; University of Belgrade;
   University of Belgrade
RP Maksimovic, M (corresponding author), Univ Belgrade, Inst Hyg & Med Ecol, Fac Med, Belgrade 11001, Serbia.
EM milos.maksimovic@mfub.bg.ac.rs
RI Maksimović, Miloš/ABF-7728-2021; jorga, jagoda/I-1383-2012
OI Vlajinac, Hristina/0000-0002-8239-2989; Maksimovic,
   Milos/0000-0002-6346-3171
FU Ministry of Education and Science Serbia [III41002]
FX The authors disclosed receipt of the following financial support for the
   research, authorship, and/or publication of this article: supported by
   Ministry of Education and Science Serbia, through contract no. III41002
   (2011-2014).
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NR 56
TC 8
Z9 9
U1 0
U2 2
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0003-3197
EI 1940-1574
J9 ANGIOLOGY
JI Angiology
PD APR
PY 2013
VL 64
IS 3
BP 230
EP 236
DI 10.1177/0003319712440303
PG 7
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 118EQ
UT WOS:000317006400011
PM 22499952
DA 2025-06-11
ER

PT J
AU Mast, BT
   Miles, T
   Penninx, BW
   Yaffe, K
   Rosano, C
   Satterfield, S
   Ayonayon, HN
   Harris, T
   Simonsick, EM
AF Mast, Benjamin T.
   Miles, Toni
   Penninx, Brenda W.
   Yaffe, Kristine
   Rosano, Caterina
   Satterfield, Suzanne
   Ayonayon, Hilsa N.
   Harris, Tamara
   Simonsick, Eleanor M.
TI Vascular disease and future risk of depressive symptomatology in older
   adults: Findings from the Health, Aging, and Body Composition study
SO BIOLOGICAL PSYCHIATRY
LA English
DT Article
DE cerebrovascular disease; geriatric depression; vascular depression
ID LATE-LIFE DEPRESSION; WHITE-MATTER HYPERINTENSITIES; SCALE CES-D;
   CEREBROVASCULAR-DISEASE; CRITERION VALIDITY; MAJOR DEPRESSION; SYMPTOMS;
   ATHEROSCLEROSIS; DYSFUNCTION; MORTALITY
AB Background: The vascular depression hypothesis suggests that age-related vascular diseases and risk factors contribute to late-life depression. Although neuroimaging studies provide evidence for an association between depression and severity of vascular lesions in the brain, studies of depression and indicators of vascular risk have been less consistent.
   Methods: We examined 1796 elders ages 70-79 from the Health, Aging and Body Composition study without depression at baseline and examined the association between prevalent vascular disease and related conditions at baseline and 2-year incidence of elevated depressive symptoms, defined as a score > 8 on the 10-item Center for Epidemiologic Studies Depression (CES-D) scale.
   Results: After adjustment for demographic data and physical and cognitive functioning, several vascular conditions remained associated with increased risk of depressive symptomatology including metabolic syndrome and its components (low high-density lipoprotein cholesterol and high fasting glucose), coronary heart disease, a positive Rose questionnaire for angina, and high hemoglobin a1c. Cumulative vascular risk based upon a composite of 10 vascular diseases and risk factors was independently associated with incident elevated depression at 2-year follow-up after controlling for demographic data, physical and cognitive functioning, and selected comorbid medical conditions.
   Conclusions: These results provide support for the vascular depression hypothesis in demonstrating an association between vascular conditions and risk factors and subsequent risk of depressive symptomatology. Older adults with vascular conditions and risk factors require close monitoring of depressive symptoms.
C1 [Mast, Benjamin T.; Miles, Toni] Univ Louisville, Louisville, KY 40292 USA.
   [Penninx, Brenda W.] VU Univ Med, Amsterdam, Netherlands.
   [Yaffe, Kristine; Ayonayon, Hilsa N.] Univ Calif San Francisco, San Francisco, CA 94143 USA.
   [Rosano, Caterina] Univ Pittsburgh, Pittsburgh, PA 15260 USA.
   [Satterfield, Suzanne] Univ Tennessee, Memphis, TN USA.
   [Harris, Tamara] NIA, Lab Epidemol Demog & Biometry, Bethesda, MD 20892 USA.
   [Simonsick, Eleanor M.] NIA, Clin Res Branch, Baltimore, MD 21224 USA.
   [Simonsick, Eleanor M.] Johns Hopkins Sch Med, Baltimore, MD USA.
C3 University of Louisville; Vrije Universiteit Amsterdam; VU UNIVERSITY
   MEDICAL CENTER; University of California System; University of
   California San Francisco; Pennsylvania Commonwealth System of Higher
   Education (PCSHE); University of Pittsburgh; University of Tennessee
   System; University of Tennessee Health Science Center; National
   Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA);
   National Institutes of Health (NIH) - USA; NIH National Institute on
   Aging (NIA); Johns Hopkins University; Johns Hopkins Medicine
RP Mast, BT (corresponding author), Univ Louisville, 317 Life Sci Bldg, Louisville, KY 40292 USA.
EM b.mast@louisville.edu
RI Yaffe, Kristine/LLL-8209-2024; Penninx, Brenda/S-7627-2017; Simonsick,
   Eleanor/W-6864-2019; Miles, Toni/ACM-0703-2022
OI Miles, Toni/0000-0003-0823-2319; Rosano, Caterina/0000-0002-0909-1506;
   Rosano, Caterina/0000-0002-4271-6010
FU NHLBI NIH HHS [R01-HL972972] Funding Source: Medline; NIA NIH HHS
   [N01-AG-6-2103, N01-AG-6-2106, N01-AG-6-2101] Funding Source: Medline;
   Intramural NIH HHS Funding Source: Medline
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   1998, OBES RES S, V6
NR 61
TC 56
Z9 69
U1 0
U2 7
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0006-3223
EI 1873-2402
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD AUG 15
PY 2008
VL 64
IS 4
BP 320
EP 326
DI 10.1016/j.biopsych.2008.01.025
PG 7
WC Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Psychiatry
GA 336IJ
UT WOS:000258357200009
PM 18367153
DA 2025-06-11
ER

PT J
AU Paparella, R
   Panvino, F
   Tarani, F
   D'Agostino, B
   Leonardi, L
   Ferraguti, G
   Venditti, S
   Colloridi, F
   Pucarelli, I
   Tarani, L
   Fiore, M
AF Paparella, Roberto
   Panvino, Fabiola
   Tarani, Francesca
   D'Agostino, Benedetto
   Leonardi, Lucia
   Ferraguti, Giampiero
   Venditti, Sabrina
   Colloridi, Fiorenza
   Pucarelli, Ida
   Tarani, Luigi
   Fiore, Marco
TI An Overview of Oxidative Stress in Sex Chromosome Aneuploidies in
   Pediatric Populations
SO ANTIOXIDANTS
LA English
DT Review
DE sex chromosome aneuploidies; antioxidants; oxidative stress; pediatrics;
   Klinefelter syndrome; Turner syndrome
ID TURNER SYNDROME; MELATONIN SECRETION; METABOLIC SYNDROME; LINKED
   INHIBITOR; BODY-COMPOSITION; POTENTIAL ROLE; ANTIOXIDANT; INFLAMMATION;
   MECHANISMS; DISEASE
AB Background: Oxidative stress, defined as an imbalance between reactive oxygen species and antioxidant defenses, plays a pivotal role in the pathogenesis of sex chromosome aneuploidies (SCAs), such as Turner syndrome (TS) and Klinefelter syndrome (KS). Pediatric patients with SCAs are particularly susceptible due to hormonal deficiencies, metabolic disturbances, and systemic complications. Methods: A comprehensive literature search was conducted in November 2024 using PubMed, Scopus, and Web of Science. Keywords included "antioxidants", "oxidative stress", "pediatrics", "Turner syndrome", "Klinefelter syndrome", and "sex chromosome aneuploidies". English-language articles were included without publication year restrictions. Relevant data on oxidative stress mechanisms and antioxidant interventions were systematically extracted. Results: The relationship between oxidative stress and SCAs can be described as bidirectional, where oxidative stress both contributes to and is exacerbated by aneuploidies. TS is marked by estrogen deficiency, cardiovascular anomalies, and metabolic dysfunction, all linked to heightened oxidative stress. KS is associated with hypogonadism, metabolic syndrome, and neurocognitive challenges, further exacerbated by oxidative damage. The aneuploid condition predisposes to increased oxidative stress in other SCAs, including 47,XXX and 47,XYY, as well as in high-grade aneuploidies. Emerging evidence highlights the therapeutic potential of antioxidants, including vitamin C, vitamin E, glutathione precursors, polyphenols, and melatonin. These interventions, when combined with hormonal therapies such as estrogen replacement in TS or testosterone replacement in KS, demonstrate synergistic effects in restoring redox balance and mitigating systemic complications. Conclusions: Oxidative stress significantly impacts the progression of SCAs in pediatric populations, amplifying risks across metabolic, cardiovascular, and neurocognitive domains. Early, tailored antioxidant strategies, integrated with syndrome-specific hormonal therapies, could reduce long-term complications and improve patient outcomes. Future research should focus on standardizing protocols to optimize these interventions for pediatric patients with SCAs.
C1 [Paparella, Roberto; Tarani, Francesca; D'Agostino, Benedetto; Leonardi, Lucia; Colloridi, Fiorenza; Pucarelli, Ida; Tarani, Luigi] Sapienza Univ Rome, Dept Maternal Infantile & Urol Sci, I-00185 Rome, Italy.
   [Panvino, Fabiola] Sapienza Univ Rome, Dept Human Neurosci, Sect Child & Adolescent Neuropsychiat, I-00185 Rome, Italy.
   [Ferraguti, Giampiero] Sapienza Univ Rome, Dept Expt Med, I-00185 Rome, Italy.
   [Venditti, Sabrina] Sapienza Univ Rome, Dept Biol & Biotechnol Charles Darwin, I-00185 Rome, Italy.
   [Fiore, Marco] Sapienza Univ Rome, Inst Biochem & Cell Biol IBBC CNR, Dept Sensory Organs, I-00185 Rome, Italy.
C3 Sapienza University Rome; Sapienza University Rome; Sapienza University
   Rome; Sapienza University Rome; Sapienza University Rome; Consiglio
   Nazionale delle Ricerche (CNR); Istituto di Biochimica e Biologia
   Cellulare (IBBC-CNR)
RP Tarani, L (corresponding author), Sapienza Univ Rome, Dept Maternal Infantile & Urol Sci, I-00185 Rome, Italy.; Fiore, M (corresponding author), Sapienza Univ Rome, Inst Biochem & Cell Biol IBBC CNR, Dept Sensory Organs, I-00185 Rome, Italy.
EM roberto.paparella@uniroma1.it; fabiola.panvino@uniroma1.it;
   francesca.tarani@uniroma1.it; benedetto.dagostino@uniroma1.it;
   lucia.leonardi@uniroma1.it; giampiero.ferraguti@uniroma1.it;
   sabrina.venditti@uniroma1.it; fiorenza.colloridi@uniroma1.it;
   ida.pucarelli@uniroma1.it; luigi.tarani@uniroma1.it; marco.fiore@cnr.it
RI Tarani, Francesca/IQU-9693-2023; Fiore, Marco/AAA-1706-2021; Paparella,
   Roberto/IUN-0187-2023
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NR 168
TC 0
Z9 0
U1 0
U2 0
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD APR 29
PY 2025
VL 14
IS 5
AR 531
DI 10.3390/antiox14050531
PG 25
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA 3AP0Z
UT WOS:001495766500001
PM 40427413
DA 2025-06-11
ER

PT J
AU Veltman, EM
   Lamers, F
   Comijs, HC
   Stek, ML
   van der Mast, RC
   Rhebergen, D
AF Veltman, E. M.
   Lamers, F.
   Comijs, H. C.
   Stek, M. L.
   van der Mast, R. C.
   Rhebergen, D.
TI Inflammatory markers and cortisol parameters across depressive subtypes
   in an older cohort
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Review
DE Latent class analysis; Depression subtypes; Inflammation; Cortisol;
   Atypical depression; Melancholic depression
ID ADRENAL AXIS ACTIVITY; LATE-LIFE DEPRESSION; UNDER-THE-CURVE; METABOLIC
   SYNDROME; SALIVARY CORTISOL; MAJOR DEPRESSION; SYMPTOMS; ASSOCIATION;
   TIME
AB Background: There is growing evidence that inflammatory and cortisol dysregulation are underlying pathophysiological mechanisms in the aetiology of major depressive disorder, particularly in younger adults. However, findings of biological disturbances in late-life depression have been divergent, probably due to the even greater heterogeneity of depression in older adults with aging processes influencing biological factors. Using empirically derived subtypes may enable the identification of biological disturbances underlying depression in older adults.
   Methods: Data were used from the Netherlands Study of Depression in Older Persons (NESDO) of 359 persons aged 60 years or older, with a current diagnosis of major depressive disorder (MDD). Depressive subtypes (severe atypical, severe melancholic, and moderate severe subtype) that were previously identified through latent class analysis (LCA), were examined on differences in inflammatory markers including C-reactive protein (CRP), in-terleukin-6 (IL-6), and neutrophil gelatinase-associated lipocalin (NGAL), as well as cortisol parameters.
   Results: No differences in measures for inflammation and cortisol across subtypes were observed in uncorrected or for putative confounders corrected models.
   Limitations: Several subjects had missing cortisol and inflammatory data, decreasing the power. However, results did not change after imputation analysis.
   Discussion: In this cohort of depressed older adults, no differences in inflammation and cortisol measures between depression subtypes were observed. This is probably due to the many (patho) physiological processes that are involved in aging, thereby clouding the results.
C1 [Veltman, E. M.; van der Mast, R. C.] Leiden Univ, Med Ctr, Dept Psychiat, Leiden, Netherlands.
   [Lamers, F.; Comijs, H. C.; Stek, M. L.; Rhebergen, D.] Vrije Univ Amsterdam, Med Ctr, Dept Psychiat, GGZ InGeest, Amsterdam, Netherlands.
   [Lamers, F.; Comijs, H. C.; Stek, M. L.; Rhebergen, D.] Vrije Univ Amsterdam, Med Ctr, Amsterdam Publ Hlth Res Inst, Amsterdam, Netherlands.
   [van der Mast, R. C.] Univ Antwerp, CAPRI, Dept Psychiat, Antwerp, Belgium.
C3 Leiden University; Leiden University Medical Center (LUMC); Leiden
   University - Excl LUMC; Vrije Universiteit Amsterdam; Vrije Universiteit
   Amsterdam; University of Antwerp
RP Veltman, EM (corresponding author), Leiden Univ, Med Ctr, Dept Psychiat, Leiden, Netherlands.
EM evelineveltman@gmail.com
RI Lamers, Femke/G-5161-2012
OI Lamers, Femke/0000-0003-4344-5766
FU European Union Seventh Framework Programme [PCIG12-GA-2012-334065];
   Fonds NutsOhra [0701-065]; Stichting totSteun VCVGZ; NARSAD The Brain
   and Behaviour Research Fund [41080]; VU University Medical Center;
   Leiden University Medical Center; University Medical Center Groningen;
   UMC St Radboud; GGZ inGeest; GG Net; GGZ Nijmegen; Parnassia
FX FL has received funding from the European Union Seventh Framework
   Programme (FP7/2007-2013) under grant agreement No.
   PCIG12-GA-2012-334065.The infrastructure for the NESDO study
   (http://nesdo.amstad.nl) is funded through the Fonds NutsOhra (project
   0701-065), Stichting totSteun VCVGZ, NARSAD The Brain and Behaviour
   Research Fund (grand ID 41080), and the participating universities and
   mental health care organizations (VU University Medical Center, Leiden
   University Medical Center, University Medical Center Groningen, UMC St
   Radboud, and GGZ inGeest, GG Net, GGZ Nijmegen and Parnassia).
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NR 47
TC 22
Z9 26
U1 0
U2 27
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD JUL
PY 2018
VL 234
BP 54
EP 58
DI 10.1016/j.jad.2018.02.080
PG 5
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA GB8EK
UT WOS:000429308000009
PM 29522944
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Park, JE
   Lee, JE
AF Park, Jong Eun
   Lee, Jung Eun
TI Cardiovascular disease risk factors and depression in Korean women:
   Results from the fourth Korean National Health and Nutrition Examination
   Survey
SO PSYCHIATRY RESEARCH
LA English
DT Article
DE Depression; Body mass index; Hyperlipidemia; Cardiovascular disease
ID MAJOR DEPRESSION; GENDER-DIFFERENCES; METABOLIC SYNDROME; GLOBAL BURDEN;
   SMOKING; EPIDEMIOLOGY; METAANALYSIS; MORTALITY; OBESITY; EVENTS
AB Depression is the fourth leading factor of disease burden for the global female population, but while increasing evidence has supported a contributing role of depression in cardiovascular disease, little is known about this association within the female population of Korea. We examined the association in a study of 5658 Korean women who participated in the fourth Korean National Health and Nutrition Examination Survey. A logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs). A total of 279 cases of depression were included. Cardiovascular disease risk factors were associated with higher odds of depression: ORs (95% CIs) were 3.99(2.25-7.05) for current smokers with <5 pack-years vs. never-smokers, 1.97 (1.18-3.30) for >= 28 vs. <20 kg/m(2) of body mass index, 1.42 (1.03-1.95) for 100-125 vs. <100 mg/dL of fasting serum glucose levels, and 2.10 (1.46-3.03) for a history of hyperlipidemia. Women with a history of two or three comorbid disorders (diabetes, hypertension, and cardiovascular disease) had a 1.63-fold higher OR for depression than women without any of these diseases. Korean women with depression had a greater prevalence of major risk factors for cardiovascular disease than women without depression. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
C1 [Park, Jong Eun; Lee, Jung Eun] Sookmyung Womens Univ, Dept Food & Nutr, Seoul 140742, South Korea.
C3 Sookmyung Women's University
RP Lee, JE (corresponding author), Sookmyung Womens Univ, Dept Food & Nutr, 52 Hyochangwon Gil, Seoul 140742, South Korea.
EM junglee@sm.ac.kr
RI Lee, Jung/AAC-5634-2020
OI Park, Jong Eun/0000-0002-4981-4238; Lee, Jung Eun/0000-0003-1141-878X
FU Sookmyung Women's University; Ministry of Education and Human Resources
   Development, Republic of Korea
FX This research was supported by the Sookmyung Women's University Research
   Grant (2010) and the Brain Korea 21 (BK 21) Project from the Ministry of
   Education and Human Resources Development, Republic of Korea.
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NR 36
TC 14
Z9 14
U1 0
U2 6
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0165-1781
EI 1872-7123
J9 PSYCHIAT RES
JI Psychiatry Res.
PD DEC 30
PY 2011
VL 190
IS 2-3
BP 232
EP 239
DI 10.1016/j.psychres.2011.05.040
PG 8
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 871FI
UT WOS:000298722900013
PM 21683455
DA 2025-06-11
ER

PT J
AU Li, SD
   Li, SL
   Duan, F
   Lu, BP
AF Li, Shudi
   Li, Suling
   Duan, Fei
   Lu, Baoping
TI Depression and NAFLD risk: A meta-analysis and Mendelian randomization
   study
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Depression; NAFLD; Meta-analysis; Mendelian randomization
ID FATTY LIVER-DISEASE; METABOLIC SYNDROME; INSULIN-RESISTANCE;
   PHYSICAL-ACTIVITY; NATIONAL-HEALTH; ASSOCIATION; DISORDERS; ADULTS;
   LIFE; MORTALITY
AB Background: Both depression and nonalcoholic fatty liver disease (NAFLD) have a high global prevalence. Growing evidence suggests an association between depression and NAFLD, while the association remains unclear. Thus, in this study, we aimed to explore the effect of depression on the risk of developing NAFLD. Methods: The meta-analysis examined the association between depression and the risk of NAFLD by including observational studies. Relevant studies were searched in PubMed, Embase, the Cochrane Library, and Web of Science. Then a two-sample Mendelian randomization (MR) analysis was performed to explore causal association using genetic instruments identified from a genome-wide association study. Results: Six eligible studies were included in the meta-analysis, involving 289,22 depression cases among 167,554 participants. Meta-analysis showed a significant association between depression and a higher risk of developing NAFLD (OR = 1.14, 95 % CI: [1.05, 1.24], P = 0.002). However, we found no convincing evidence supporting a causal role of genetically predicted depression with NAFLD risk (OR = 0.861, 95 % CI: [0.598, 1.238], P = 0.420). Limitations: The insufficient number of included studies, the use of summary-level data, and restrictions on population sources are the major limiting factors. Conclusions: Meta-analysis and MR analysis demonstrated inconsistent results on the relationship between depression and a high risk of developing NAFLD. Specifically, meta-analysis confirmed that depression increases the risk of developing NAFLD, while MR analysis did not support a causal association between genetically determined depression and the risk of NAFLD.
C1 [Li, Shudi] Henan Univ Chinese Med, Clin Med Coll 2, Zhengzhou 450000, Peoples R China.
   [Li, Suling; Duan, Fei] Henan Univ TCM, Affiliated Hosp 1, Zhengzhou 450000, Peoples R China.
   [Lu, Baoping] Henan Univ Chinese Med, Zhengzhou 450046, Peoples R China.
   [Lu, Baoping] 156 Jinshui East Rd, Zhengzhou 450046, Henan, Peoples R China.
C3 Henan University of Traditional Chinese Medicine; Henan University of
   Traditional Chinese Medicine; Henan University of Traditional Chinese
   Medicine
RP Lu, BP (corresponding author), 156 Jinshui East Rd, Zhengzhou 450046, Henan, Peoples R China.
EM lbp1921@sohu.com
RI Duan, Fei/A-3830-2011
FU National famous traditional Chinese medicine Maudxi inherit-ance studio
   construction project [[2018] 119]; Henan Province Chinese medicine
   scientific research special topic [2022ZY1167]; National Clinical
   Research Base of Traditional Chinese Medicine, Henan Provincial Health
   Commission [2021 JDZX2014]
FX This study was supported by National famous traditional Chinese medicine
   Maudxi inherit-ance studio construction project (China Medical Office
   teaching Letter [2018] 119) , Henan Province Chinese medicine scientific
   research special topic (2022ZY1167) , National Clinical Research Base of
   Traditional Chinese Medicine, Henan Provincial Health Commission (2021
   JDZX2014) .
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NR 51
TC 4
Z9 4
U1 3
U2 23
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD MAY 1
PY 2024
VL 352
BP 379
EP 385
DI 10.1016/j.jad.2024.02.074
EA FEB 2024
PG 7
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA NT3O5
UT WOS:001202668300001
PM 38387674
OA hybrid
DA 2025-06-11
ER

PT J
AU Chang, NT
   Su, TC
AF Chang, Nien-Tzu
   Su, Ta-Chen
TI Investigating the association between familial hypercholesterolemia and
   perceived depression
SO ATHEROSCLEROSIS SUPPLEMENTS
LA English
DT Article
DE Familial hypercholesterolemia; Depression; Coronary heart disease
ID CORONARY-HEART-DISEASE; QUALITY-OF-LIFE; RISK-FACTOR;
   CARDIOVASCULAR-DISEASE; GENDER-DIFFERENCES; METABOLIC SYNDROME;
   YOUNG-ADULTS; HEALTH; EXPERIENCES; PREVALENCE
AB Background and aims: Inherited familial hypercholesterolemia (FH) increases cardiovascular risks, but perceived depression in FH is unknown. This study aims to explore the association between the FH and perceived depression.
   Methods: This study was a hospital-based design, we started to recruit clinical diagnosis of phenotypic FH since 2014 for the Ten Countries Study in the Asia-Pacific region. We consecutively recruited 302 FH patients and other 414 comparison subjects (214 subjects with hypertriglyceridemia and 200 subjects with normal lipid controls) from the special lipid clinic of National Taiwan University Hospital, Taipei. All participants received cardiovascular health examinations and completed a self-reported questionnaire, including the Center for Epidemiologic Studies Depression Scale (CES-D) for assessment of the psychosocial depression.
   Results: Clinical FH patients had a higher risk of perceived depression, with an odds ratio (95% confidence intervals) of possible depression by 1.50 (1.07-2.11) and probable depression by 1.73 (1.10-2.75) than those of the non-FH groups after adjusted relevant cardiovascular risk factors. FH patients with a family history of coronary heart disease (CHD) had higher domain-specific depression scores than those of controls. In addition, this study found that FH patients with lower educational levels also had a higher risk of depression compared with those in control groups.
   Conclusions: Patients with clinical phenotype of FH are associated with subjectively perceived depression, particularly among FH patients with a family history of CHD. (c) 2019 Elsevier B.V. All rights reserved.
C1 [Chang, Nien-Tzu] Natl Taiwan Univ, Sch Nursing, Coll Med, Taipei 10002, Taiwan.
   [Su, Ta-Chen] Natl Taiwan Univ Hosp, Dept Internal Med, 7 Chung Shan South Rd, Taipei 10002, Taiwan.
   [Su, Ta-Chen] Natl Taiwan Univ Hosp, Cardiovasc Ctr, 7 Chung Shan South Rd, Taipei 10002, Taiwan.
   [Su, Ta-Chen] Natl Taiwan Univ, Coll Publ Hlth, Inst Occupat Med & Ind Hyg, Taipei 10020, Taiwan.
   [Su, Ta-Chen] Natl Taiwan Univ Hosp, Dept Environm & Occupat Med, Taipei, Taiwan.
   [Su, Ta-Chen] Natl Taiwan Univ, Coll Med, Taipei, Taiwan.
C3 National Taiwan University; National Taiwan University; National Taiwan
   University Hospital; National Taiwan University; National Taiwan
   University Hospital; National Taiwan University; National Taiwan
   University; National Taiwan University Hospital; National Taiwan
   University
RP Su, TC (corresponding author), Natl Taiwan Univ Hosp, Dept Internal Med, 7 Chung Shan South Rd, Taipei 10002, Taiwan.; Su, TC (corresponding author), Natl Taiwan Univ Hosp, Cardiovasc Ctr, 7 Chung Shan South Rd, Taipei 10002, Taiwan.
EM tachensu@gmail.com
RI , shen/GXH-0183-2022
OI SU, TA-CHEN/0000-0001-7523-7166; Chang, Nien-Tzu/0000-0001-7611-3843
FU National Science Council of Taiwan [NSC102-2314-B-002-004]; National
   Taiwan University [NTU-CDP-104R7811]; National Taiwan University
   Hospital [NTUH 106-S3521]
FX This study was supported by research grants from the National Science
   Council of Taiwan (NSC102-2314-B-002-004) and National Taiwan University
   (NTU-CDP-104R7811). This study was also supported by the National Taiwan
   University Hospital (NTUH 106-S3521).
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   WHO, 2001, MENT HLTH REP WHO
NR 37
TC 7
Z9 7
U1 0
U2 2
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 1567-5688
EI 1878-5050
J9 ATHEROSCLEROSIS SUPP
JI Atheroscler. Suppl.
PD MAR
PY 2019
VL 36
BP 31
EP 36
DI 10.1016/j.atherosclerosissup.2019.01.007
PG 6
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Cardiovascular System & Cardiology
GA HO4NV
UT WOS:000460900500007
PM 30876531
DA 2025-06-11
ER

PT J
AU Boylan, JM
   Ryff, CD
AF Boylan, Jennifer Morozink
   Ryff, Carol D.
TI Psychological Well-Being and Metabolic Syndrome: Findings From the
   Midlife in the United States National Sample
SO PSYCHOSOMATIC MEDICINE
LA English
DT Article
ID MENTAL-HEALTH; OLDER-ADULTS; LIFE; THERAPY; INTERLEUKIN-6;
   PSYCHOTHERAPY; ASSOCIATION; PROTOCOL; RISK
AB Objectives
   Psychological well-being predicts favorable cardiovascular outcomes, but less evidence addresses biological mediators underlying these effects. Therefore, associations among well-being and metabolic syndrome (MetSyn) were examined in a national sample.
   Methods
   Survey of Midlife in the US participants (MIDUS; n = 1205) provided survey assessments of hedonic (positive affect, life satisfaction) and eudaimonic well-being (e.g., personal growth and purpose in life) at two waves 9 to 10 years apart. MetSyn components were measured during an overnight clinic visit at Time 2 only. Outcomes included the number of MetSyn risk factors and a binary outcome reflective of MetSyn status.
   Results
   The unadjusted prevalence of MetSyn was 36.6%. Life satisfaction (B [standard error {SE}] = -0.12 [0.04], p = .005), positive affect (B [SE] = -0.10 [0.04], p = .009), and personal growth (B [SE] = -0.10 [0.04], p = .012) predicted fewer MetSyn components and lower risk of meeting diagnostic criteria in fully adjusted models.
   Results were unchanged by adjustments for depressive symptoms, and were not moderated by age, sex, race, or socioeconomic status. Life satisfaction (B [SE] = -0.11 [0.05], p = .023) and a eudaimonic well-being composite (B [SE] = -0.11 [0.05], p = .045) also predicted fewer components and lower risk of meeting diagnostic criteria in longitudinal models.
   Conclusions
   Psychosocial resources, including positive affect, life satisfaction, and personal growth, predicted reduced risk for MetSyn both cross sectionally and longitudinally. Further work should examine consequences of these linkages for cardiovascular outcomes in intervention contexts.
C1 [Boylan, Jennifer Morozink] Univ Pittsburgh, Dept Psychiat, Pittsburgh, PA 15213 USA.
   [Ryff, Carol D.] Univ Wisconsin, Dept Psychol, Madison, WI 53706 USA.
   [Ryff, Carol D.] Univ Wisconsin, Inst Aging, Madison, WI USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE); University
   of Pittsburgh; University of Wisconsin System; University of Wisconsin
   Madison; University of Wisconsin System; University of Wisconsin Madison
RP Boylan, JM (corresponding author), Univ Pittsburgh, Dept Psychiat, 3811 OHara St, Pittsburgh, PA 15213 USA.
EM boylanja@upmc.edu
RI Boylan, Jennifer/B-9288-2016
OI Boylan, Jennifer/0000-0003-2597-1367
FU National Institute on Aging at the National Institutes of Health
   [P01-AG020166]; John D. and Catherine T. MacArthur Foundation Research
   Network on Successful Midlife Development; (Georgetown) from the General
   Clinical Research Centers Program [M01-RR023942]; (University of
   California, Los Angeles) from the General Clinical Research Centers
   Program [M01-RR00865]; (University of Wisconsin) from the Clinical and
   Translational Science Award program of the National Center for Research
   Resources, National Institutes of Health [1UL1RR025011]; National Heart,
   Lung, and Blood Institute [5T32HL007560-32]
FX Source of Funding and Conflicts of Interest: This work was supported by
   the National Institute on Aging at the National Institutes of Health
   (P01-AG020166) to conduct a longitudinal follow-up of the MIDUS
   investigation (Dr. Ryff). The original study was supported by the John
   D. and Catherine T. MacArthur Foundation Research Network on Successful
   Midlife Development. Support also came from the following grants:
   M01-RR023942 (Georgetown), M01-RR00865 (University of California, Los
   Angeles) from the General Clinical Research Centers Program, and
   1UL1RR025011 (University of Wisconsin) from the Clinical and
   Translational Science Award program of the National Center for Research
   Resources, National Institutes of Health. J.M.B. is supported by a
   training grant from the National Heart, Lung, and Blood Institute
   (5T32HL007560-32). The content is solely the responsibility of the
   authors and does not necessarily represent the official views of the
   National Heart, Lung, and Blood Institute or the National Institutes of
   Health. Both authors declare no conflicts of interest.
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NR 46
TC 57
Z9 71
U1 0
U2 41
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0033-3174
EI 1534-7796
J9 PSYCHOSOM MED
JI Psychosom. Med.
PD JUN
PY 2015
VL 77
IS 5
BP 548
EP 558
DI 10.1097/PSY.0000000000000192
PG 11
WC Psychiatry; Psychology; Psychology, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry; Psychology
GA CK5FE
UT WOS:000356247100007
PM 25984827
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Kosyreva, AM
   Sentyabreva, AV
   Tsvetkov, IS
   Makarova, OV
AF Kosyreva, Anna Mikhailovna
   Sentyabreva, Alexandra Vladislavovna
   Tsvetkov, Ivan Sergeevich
   Makarova, Olga Vasilievna
TI Alzheimer's Disease and Inflammaging
SO BRAIN SCIENCES
LA English
DT Review
DE inflammation; neurodegeneration; aging; atherosclerosis; metabolic
   syndrome; depression; Alzheimer's disease
ID INSULIN-DEGRADING ENZYME; NEURAL STEM-CELLS; AMYLOID-BETA; SYSTEMIC
   INFLAMMATION; COGNITIVE IMPAIRMENT; SELECTIVE AUTOPHAGY;
   DIABETES-MELLITUS; NUCLEUS BASALIS; MOUSE MODEL; IKK-BETA
AB Alzheimer's disease is one of the most common age-related neurodegenerative disorders. The main theory of Alzheimer's disease progress is the amyloid-beta cascade hypothesis. However, the initial mechanisms of insoluble forms of amyloid-beta formation and hyperphosphorylated tau protein in neurons remain unclear. One of the factors, which might play a key role in senile plaques and tau fibrils generation due to Alzheimer's disease, is inflammaging, i.e., systemic chronic low-grade age-related inflammation. The activation of the proinflammatory cell phenotype is observed during aging, which might be one of the pivotal mechanisms for the development of chronic inflammatory diseases, e.g., atherosclerosis, metabolic syndrome, type 2 diabetes mellitus, and Alzheimer's disease. This review discusses the role of the inflammatory processes in developing neurodegeneration, activated during physiological aging and due to various diseases such as atherosclerosis, obesity, type 2 diabetes mellitus, and depressive disorders.
C1 [Kosyreva, Anna Mikhailovna; Sentyabreva, Alexandra Vladislavovna; Tsvetkov, Ivan Sergeevich; Makarova, Olga Vasilievna] FSBI Petrovsky Natl Res Ctr Surg, Avtsyn Sci Res Inst Human Morphol, Moscow 117418, Russia.
RP Sentyabreva, AV (corresponding author), FSBI Petrovsky Natl Res Ctr Surg, Avtsyn Sci Res Inst Human Morphol, Moscow 117418, Russia.
EM alexandraasentyabreva@gmail.com
RI Tsv, Ivan/AAC-3517-2019; Kosyreva, Anna/U-3557-2019
OI Sentyabreva, Alexandra/0000-0001-5064-219X; Tsvetkov,
   Ivan/0000-0003-0946-1105; Kosyreva, Anna/0000-0002-6182-1799
FU  [122030200530-6]
FX Number of state registration of research, development, and technological
   work for civil purposes-122030200530-6.
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NR 207
TC 49
Z9 54
U1 3
U2 65
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3425
J9 BRAIN SCI
JI Brain Sci.
PD SEP
PY 2022
VL 12
IS 9
AR 1237
DI 10.3390/brainsci12091237
PG 24
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 4T5AU
UT WOS:000858130700001
PM 36138973
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Baye, E
   Naderpoor, N
   Misso, M
   Teede, H
   Moran, LJ
   de Courten, B
AF Baye, Estifanos
   Naderpoor, Negar
   Misso, Marie
   Teede, Helena
   Moran, Lisa J.
   de Courten, Barbora
TI Treatment with high dose salicylates improves cardiometabolic
   parameters: Meta-analysis of randomized controlled trials
SO METABOLISM-CLINICAL AND EXPERIMENTAL
LA English
DT Article
DE Salicylates; Type 2 diabetes; Cardiovascular disease; Chronic
   inflammation; Meta-analysis
ID TYPE-2 DIABETES-MELLITUS; INSULIN-RESISTANCE; ENDOTHELIAL DYSFUNCTION;
   SALSALATE TREATMENT; KAPPA-B; TARGETING INFLAMMATION; GLUCOSE-TOLERANCE;
   OXIDATIVE STRESS; ADIPOSE-TISSUE; ASPIRIN
AB Introduction. There is conflicting evidence regarding the efficacy of high dose salicylates in improving cardiometabolic risk in healthy and type 2 diabetes patients. We aimed to determine whether treatment with salicylates at an anti-inflammatory dose (>= 1 g daily) would improve cardiometabolic risk in healthy individuals and type 2 diabetes patients, compared to placebo.
   Methods. Medline, Medline-in-process, Embase, and all EBM databases were searched for studies published up to December 2016. Twenty-eight articles from 24 studies comprising 1591 participants were included. Two reviewers independently assessed the risk of bias and extracted data from included studies. Meta-analyses using random-effects model were used to analyze the data.
   Results. High dose salicylates (>= 3 g/d) decreased fasting glucose (MD -0.4 mmol/l, 95% CI -0.54, -0.27) and glucose area under the curve (MD -0.41 mmol/l, 95% CI -0.81, -0.01). Salicylates (>= 3 g/d) also increased fasting insulin (MD 2.4 mu U/ml, 95% CI 0.3, 4.4), 2-h insulin (MD 25.4 mu U/ml, 95% CI 8.2, 42.6), insulin secretion (MD 79.2, 95% CI 35, 173) but decreased fasting C-peptide (MD -0.11 nmol/l, 95% CI -0.2, -0.04), insulin clearance (MD -0.26 l/min, 95% CI -0.36, -0.16) and triglycerides (MD -0.36 mmol/l, 95% CI -0.51, -0.21) and increased total adiponectin (MD 1.97 mu g/ml, 95% CI 0.99, 2.95). A lower salicylate dose (1-2.9 g) did not change any cardiometabolic parameters (p > 0.1). No significant difference was observed between those receiving salicylates and placebo following withdrawal due to adverse events.
   Conclusions. High dose salicylates appear to improve cardiometabolic risk factors in healthy individuals and type 2 diabetes patients. (C) 2017 Elsevier Inc. All rights reserved.
C1 [Baye, Estifanos; Naderpoor, Negar; Misso, Marie; Teede, Helena; Moran, Lisa J.; de Courten, Barbora] Monash Univ, Sch Publ Hlth & Prevent Med, Monash Ctr Hlth Res & Implementat, 43-51 Kanooka Grove, Clayton, Vic 3168, Australia.
   [Naderpoor, Negar; Teede, Helena; de Courten, Barbora] Monash Hlth, Diabet & Vasc Med Unit, Locked Bag 29, Clayton, Vic 3168, Australia.
C3 Monash University; Monash Health
RP de Courten, B (corresponding author), Monash Univ, Sch Publ Hlth & Prevent Med, Monash Ctr Hlth Res & Implementat, 43-51 Kanooka Grove, Clayton, Vic 3168, Australia.
EM barbora.decourten@monash.edu
RI Naderpoor, Negar/IUM-7706-2023; Moran, Lisa/E-9850-2015; de Courten,
   Barbora/B-3308-2012
OI Baye, Estifanos/0000-0002-2937-356X; de Courten,
   Barbora/0000-0001-8760-2511; Moran, Lisa/0000-0001-5772-6484; Naderpoor,
   Negar/0000-0002-1738-3189; Teede, Helena/0000-0001-7609-577X
FU Monash Graduate Scholarship; Monash International Postgraduate
   Scholarship; Australian Postgraduate Award by Monash University;
   National Heart Foundation Fellowship [100864]; South Australian
   Cardiovascular Research Development Program Fellowship [ID AC115374];
   National Heart Foundation; South Australian Department of Health; South
   Australian Health and Medical Research Institute
FX EB is a recipient of Monash Graduate Scholarship and Monash
   International Postgraduate Scholarship. NN is a recipient Australian
   Postgraduate Award provided by Monash University. HT is a National
   Health and Medical Research Council Fellow. BdC is supported by a
   National Heart Foundation Fellowship (100864). L.J.M. is supported by a
   South Australian Cardiovascular Research Development Program Fellowship
   (ID AC115374); a program collaboratively funded by the National Heart
   Foundation, the South Australian Department of Health and the South
   Australian Health and Medical Research Institute. We would like to thank
   Dr. Juraj Koska for his valuable feedback on the manuscript.
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NR 59
TC 4
Z9 5
U1 0
U2 4
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0026-0495
EI 1532-8600
J9 METABOLISM
JI Metab.-Clin. Exp.
PD JUN
PY 2017
VL 71
BP 94
EP 106
DI 10.1016/j.metabol.2017.03.006
PG 13
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA EW5YW
UT WOS:000402583400010
PM 28521883
DA 2025-06-11
ER

PT J
AU Pelletier, JR
   Nguyen, M
   Bradley, K
   Johnsen, M
   McKay, C
AF Pelletier, JR
   Nguyen, M
   Bradley, K
   Johnsen, M
   McKay, C
TI A study of a structured exercise program with members of an ICCD
   certified clubhouse: Program design, benefits, and implications for
   feasibility
SO PSYCHIATRIC REHABILITATION JOURNAL
LA English
DT Article
ID PSYCHIATRIC-DISORDERS; METABOLIC SYNDROME; MORTALITY; HEALTH;
   PREVALENCE; OBESITY; ADULTS; RISK
AB Individuals with serious mental illness (SMI) have significantly greater risk of co-morbid health problems and premature death, and there is need for interventions that can improve physical fitness and overall health. Accordingly, a study was conducted which evaluated the effectiveness of a structured physical exercise program that was developed as part of a wellness project in an ICCD Certified Clubhouse. Seventeen clubhouse members completed a 16-week program with evidence of significant improvement in aerobic capacity and perceived mental health as well as positive trends in perceived improvements in physical and social functioning. Qualitative data indicated satisfaction with the program by all participants, especially the value of group support, while also highlighting the need for greater attention to nutrition as part of a future program. Moreover, the study found that a structured exercise program can be successfully provided to members of an ICCD Certified Clubhouse.
C1 Assumption Coll, Inst Social & Rehab Serv, Worcester, MA 01609 USA.
   Univ Massachusetts, Sch Med, Ctr Mental Htlh Serv Res, Program Clubhouse Res, Amherst, MA 01003 USA.
C3 Assumption College; University of Massachusetts System; University of
   Massachusetts Amherst
RP Assumption Coll, Inst Social & Rehab Serv, 500 Salibury St, Worcester, MA 01609 USA.
EM jpelleti@assumption.edu
RI McKay, Colleen/LMN-3770-2024
OI McKay, Colleen/0000-0001-8578-6222
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NR 28
TC 23
Z9 33
U1 0
U2 5
PU EDUCATIONAL PUBLISHING FOUNDATION-AMERICAN PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST, NE, WASHINGTON, DC 20002-4242 USA
SN 1095-158X
EI 1559-3126
J9 PSYCHIATR REHABIL J
JI Psychiatr. Rehabil. J.
PD FAL
PY 2005
VL 29
IS 2
BP 89
EP 96
DI 10.2975/29.2005.89.96
PG 8
WC Psychiatry; Rehabilitation
WE Social Science Citation Index (SSCI)
SC Psychiatry; Rehabilitation
GA 974JT
UT WOS:000232588400002
PM 16268003
DA 2025-06-11
ER

PT J
AU Alves, FCR
   Moreira, A
   Moutinho, O
AF Alves, Fernanda Cristina Ribeiro
   Moreira, Ana
   Moutinho, Osvaldo
TI Maternal and long-term offspring outcomes of obesity during pregnancy
SO ARCHIVES OF GYNECOLOGY AND OBSTETRICS
LA English
DT Review
DE Pregnancy; Maternal obesity; Risk management; Offspring
ID BODY-MASS INDEX; GESTATIONAL WEIGHT-GAIN; BARIATRIC SURGERY;
   PHYSICAL-ACTIVITY; INTERNATIONAL FEDERATION; NONCOMMUNICABLE DISEASES;
   CESAREAN DELIVERY; PREPREGNANCY BMI; FIGO PREGNANCY; POSITION PAPER
AB PurposeObesity`s prevalence is rising in women of reproductive age worldwide and has become the most common medical condition at this age group. Besides, its occurrence is also rising during pregnancy. This condition not only increases the risk of noncommunicable diseases on the mother, such as cardiovascular disease and diabetes, but also transfers this risk to the offspring.MethodsThis is a narrative review based on scientific and review articles on the matter.ResultsObesity is associated with an increased risk of gestational diabetes mellitus, gestational hypertension and preeclampsia, venous thromboembolism, infection, and mental health problems. Furthermore, it has an impact on the progress of labor and induction matters. Regarding offspring outcomes, it is related to higher incidence of congenital anomalies, perinatal mortality, and the occurrence of large for gestational age newborns. Still, it has implications on cardiometabolic risk and neurodevelopment in offspring.ConclusionIt is, therefore, imperative to encourage the adoption of healthy lifestyles, especially in the peri-conception and interpregnancy periods. Likewise, there must be support in the multidisciplinary monitoring of these pregnant women to minimize associated complication rates.
C1 [Alves, Fernanda Cristina Ribeiro; Moreira, Ana; Moutinho, Osvaldo] Ctr Hosp Tras Os Montes & Alto Douro, Obstet & Gynecol Dept, Ave Noruega, Vila Real, Portugal.
RP Alves, FCR (corresponding author), Ctr Hosp Tras Os Montes & Alto Douro, Obstet & Gynecol Dept, Ave Noruega, Vila Real, Portugal.
EM alves.fcr@sapo.pt
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NR 78
TC 11
Z9 11
U1 1
U2 5
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0932-0067
EI 1432-0711
J9 ARCH GYNECOL OBSTET
JI Arch. Gynecol. Obstet.
PD JUN
PY 2024
VL 309
IS 6
BP 2315
EP 2321
DI 10.1007/s00404-023-07349-2
EA MAR 2024
PG 7
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA SZ4S9
UT WOS:001187476300006
PM 38502190
DA 2025-06-11
ER

PT J
AU Priftis, N
   Panagiotakos, D
AF Priftis, Nikos
   Panagiotakos, Demosthenes
TI Screen Time and Its Health Consequences in Children and Adolescents
SO CHILDREN-BASEL
LA English
DT Review
DE screen time; digital media; children; adolescents; review
ID SLEEP; DISORDER; EXPOSURE; OBESITY; HABITS
AB Nowadays, children and adolescents are exposed to digital media (DM) from an early age. Therefore, specific guidelines have been published by the World Health Organization, whose aim is to limit daily screen time (ST) viewing. However, during the COVID-19 pandemic, a rise in DM use, and consequently ST viewing, was observed. More and more aspects of modern life are thought to be affected by excessive ST viewing. Accordingly, the aim of this review is to document the health effects of excessive ST viewing on children and adolescents. A narrative review was performed in searchable databases. In total, 43 original articles were considered. Excessive ST viewing was correlated with increased risk for obesity and other cardiometabolic risk factors, mental health, unhealthy dietary habits and eating disorders, and problems in development and child-parent relationships. Sleep, physical activity, eyesight, headaches, and the musculoskeletal system were negatively affected as well. However, the effect of ST was weighted by the type of media used and the way types of media were used. Other confounding factors were reported. There is evidence to suggest a negative correlation between excessive ST and youth health exists. Nevertheless, more research is needed if this correlation is to be established.
C1 [Priftis, Nikos] Natl & Kapodistrian Univ Athens, Sch Med, Athens 11527, Greece.
   [Panagiotakos, Demosthenes] Harokopio Univ, Sch Hlth Sci & Educ, Athens 17671, Greece.
C3 Athens Medical School; National & Kapodistrian University of Athens;
   Harokopio University Athens
RP Panagiotakos, D (corresponding author), Harokopio Univ, Sch Hlth Sci & Educ, Athens 17671, Greece.
EM nk.priftis84@gmail.com; dbpanag@hua.gr
RI Panagiotakos, Demosthenes/K-8294-2019
OI Priftis, Nikos/0009-0003-7575-4974
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NR 72
TC 21
Z9 21
U1 15
U2 51
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2227-9067
J9 CHILDREN-BASEL
JI Children-Basel
PD OCT
PY 2023
VL 10
IS 10
AR 1665
DI 10.3390/children10101665
PG 17
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA W8OD5
UT WOS:001094157500001
PM 37892328
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Leite, CE
   Mocelin, CA
   Petersen, GO
   Leal, MB
   Thiesen, FV
AF Leite, Carlos E.
   Mocelin, Clei A.
   Petersen, Guilherme O.
   Leal, Mirna B.
   Thiesen, Flavia V.
TI Rimonabant: an antagonist drug of the endocannabinoid system for the
   treatment of obesity
SO PHARMACOLOGICAL REPORTS
LA English
DT Review
DE endocannabinoids; obesity; rimonabant; psychiatric alterations
ID CARDIOMETABOLIC RISK-FACTORS; CANNABINOID-1 RECEPTOR BLOCKER; OVERWEIGHT
   PATIENTS; FOOD-INTAKE; WEIGHT; EFFICACY; SAFETY; MODULATION
AB Obesity, an ever-increasing problem in the industrialized world, has long been a target of research for a cure or, at least, control of its expansion. In the search for treatment, the recently discovered endocannabinoid system has emerged as a new target for controlling obesity and its associated conditions. The endocannabinoid system plays an important role in controlling weight and energy balance in humans. This system is activated to a greater extent in obese patients, and the specific blockage of its receptors is the aim of rimonabant, one of the most recent drugs created for the treatment of obesity. This drug acts as a blockade for endocannabinoid receptors found in the brain and peripheral organs that play an important role on carbohydrate and fat metabolism. Clinical studies have confirmed that, when used in combination with a low calorie diet, rimonabant promotes loss in body weight, loss in abdominal circumference, and improvements in dyslipidemia. Rimonabant is also being tested as a potential anti-smoking treatment since endocannabinoids are related to the pleasurable effect of nicotine. Thus, rimonabant constitutes a new therapeutic approach to obesity and cardiovascular risk factors. Studies show effectiveness in weight loss; however, side effects such as psychiatric alterations have been reported, including depression and anxiety. These side effects have led the FDA (Food and Drug Administration) to not approve this drug in the United States. For a more complete evaluation on the safety of this drug, additional studies are in progress.
C1 [Leite, Carlos E.; Petersen, Guilherme O.; Thiesen, Flavia V.] Pontificia Univ Catolica Rio Grande do Sul, Inst Toxicol, BR-90619900 Porto Alegre, RS, Brazil.
   [Mocelin, Clei A.; Petersen, Guilherme O.; Thiesen, Flavia V.] Pontificia Univ Catolica Rio Grande do Sul, Fac Pharm, BR-90619900 Porto Alegre, RS, Brazil.
   [Leal, Mirna B.] Pontificia Univ Catolica Rio Grande do Sul, Dept Pharmacol, BR-90619900 Porto Alegre, RS, Brazil.
C3 Pontificia Universidade Catolica Do Rio Grande Do Sul; Pontificia
   Universidade Catolica Do Rio Grande Do Sul; Pontificia Universidade
   Catolica Do Rio Grande Do Sul
RP Thiesen, FV (corresponding author), Pontificia Univ Catolica Rio Grande do Sul, Inst Toxicol, Av Ipiranga 6681,Predio 12,Bloco D,Sala 140, BR-90619900 Porto Alegre, RS, Brazil.
EM fvthiesen@pucrs.br
RI Leal, Mirna/A-9704-2017; Leite, Carlos Eduardo/U-4395-2017; Herrmann,
   Ana P/F-3694-2011; thiesen, flavia/A-3470-2017
OI Leite, Carlos Eduardo/0000-0002-6845-1612; Herrmann, Ana
   P/0000-0002-0330-0741; thiesen, flavia/0000-0003-4907-6789
CR [Anonymous], REV BRASILEIRA NUTR
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NR 41
TC 73
Z9 80
U1 0
U2 11
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1734-1140
EI 2299-5684
J9 PHARMACOL REP
JI Pharmacol. Rep.
PD MAR-APR
PY 2009
VL 61
IS 2
BP 217
EP 224
DI 10.1016/S1734-1140(09)70025-8
PG 8
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 446PS
UT WOS:000266134200002
PM 19443932
DA 2025-06-11
ER

PT J
AU Walker, BR
   Soderberg, S
   Lindahl, B
   Olsson, T
AF Walker, BR
   Soderberg, S
   Lindahl, B
   Olsson, T
TI Independent effects of obesity and cortisol in predicting cardiovascular
   risk factors in men and women
SO JOURNAL OF INTERNAL MEDICINE
LA English
DT Article
DE blood pressure; glucocorticoids; insulin resistance; obesity
ID BODY-FAT DISTRIBUTION; INSULIN-RESISTANCE SYNDROME;
   POLYCYSTIC-OVARY-SYNDROME; PITUITARY-ADRENAL AXIS;
   11-BETA-HYDROXYSTEROID DEHYDROGENASE; ESSENTIAL-HYPERTENSION; ABDOMINAL
   OBESITY; SECRETION; STRESS
AB Objectives. Recent data suggest that higher plasma cortisol may be associated with hypertension and insulin resistance in otherwise healthy men, as it is in Cushing's syndrome. However, obesity in women is associated with lower plasma cortisol concentrations. This study sought to establish whether plasma cortisol is associated with cardiovascular risk factors in women as it is in men, and whether these relationships in either sex are confounded by obesity.
   Design. A population-based cross-sectional study.
   Setting. The MONICA study in northern Sweden.
   Subjects. From a target cohort of 2500, 1921 subjects took part and 226 were randomly selected because they attended between 07.00 and 09.00 h after an overnight fast. A 75 g oral glucose tolerance test was performed and blood sampled at baseline and 2 h after glucose.
   Results. Plasma cortisol was lower in relatively obese subjects: in men, this was observed only in the 2 h sample (r = -0.23, P = 0.02) and in women only in the fasting sample (r = -0.26, P < 0.01). Simple regression analysis did not identify relationships between plasma cortisol and blood pressure, serum lipids, fasting insulin or glucose tolerance. However, after adjusting for the effect of obesity by multiple regression, higher plasma cortisol was independently associated with higher diastolic blood pressure in men (r = 0.21, P = 0.04) but not in women, and higher fasting serum triglyceride levels in women (r = 0.28, P < 0.001) but not in men.
   Conclusions. Increasing obesity and plasma cortisol concentrations make independent and sex-specific contributions to variations in blood pressure and aspects of the insulin resistance syndrome. Adverse cardiovascular risk is greatest in those with the combination of obesity and failure to downregulate plasma cortisol levels.
C1 Univ Edinburgh, Western Gen Hosp, Dept Med, Edinburgh EH4 2XU, Midlothian, Scotland.
   Umea Univ, Dept Med, Univ Hosp, Umea, Sweden.
C3 University of Edinburgh; Umea University; Umea University Hospital
RP Walker, BR (corresponding author), Univ Edinburgh, Western Gen Hosp, Dept Med Sci, Edinburgh EH4 2XU, Midlothian, Scotland.
RI Söderberg, Stefan/AAG-3881-2019; Olsson, Tommy/KCZ-0891-2024
OI Soderberg, Stefan/0000-0001-9225-1306; Olsson, Tommy/0000-0001-7768-1076
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NR 20
TC 121
Z9 130
U1 0
U2 5
PU BLACKWELL SCIENCE LTD
PI OXFORD
PA P O BOX 88, OSNEY MEAD, OXFORD OX2 0NE, OXON, ENGLAND
SN 0954-6820
J9 J INTERN MED
JI J. Intern. Med.
PD FEB
PY 2000
VL 247
IS 2
BP 198
EP 204
DI 10.1046/j.1365-2796.2000.00609.x
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 289MQ
UT WOS:000085625900005
PM 10692082
DA 2025-06-11
ER

PT J
AU Lynch, EB
   Williams, J
   Avery, E
   Crane, MM
   Lange-Maia, B
   Tangney, C
   Jenkins, L
   Dugan, SA
   Emery-Tiburcio, EE
   Epting, SM
AF Lynch, Elizabeth B.
   Williams, Joselyn
   Avery, Elizabeth
   Crane, Melissa M.
   Lange-Maia, Brittney
   Tangney, Christy
   Jenkins, LaDawne
   Dugan, Sheila A.
   Emery-Tiburcio, Erin E.
   Epting, Steve M.
TI Partnering with Churches to Conduct a Wide-Scale Health Screening of an
   Urban, Segregated Community
SO JOURNAL OF COMMUNITY HEALTH
LA English
DT Article
DE African American; Health disparities; Surveillance; Segregation
ID BLOOD-PRESSURE-MEASUREMENT; RACIAL RESIDENTIAL SEGREGATION;
   UNITED-STATES; MEASUREMENT DEVICE; PHYSICAL-ACTIVITY; PRIMARY-CARE;
   DISPARITIES; CHICAGO; ASSOCIATION; MORTALITY
AB West Side Alive (WSA) is a partnership among pastors, church members and health researchers with the goal of improving health in the churches and surrounding community in the West Side of Chicago, a highly segregated African American area of Chicago with high rates of premature mortality and social disadvantage. To inform health intervention development, WSA conducted a series of health screenings that took place in seven partner churches. Key measures included social determinants of health and healthcare access, depression and PTSD screeners, and measurement of cardiometabolic risk factors, including blood pressure, weight, cholesterol and hemoglobin A1C (A1C). A total of 1106 adults were screened, consisting of WSA church members (n=687), members of the local community served by the church (n=339) and 80 individuals with unknown church status. Mean age was 52.8 years, 57% were female, and 67% reported at least one social risk factor (e.g. food insecurity). Almost all participants had at least one cardiovascular risk factor (92%), including 50% with obesity, 79% with elevated blood pressure and 65% with elevated A1C. A third of participants experienced >= 4 potentially traumatic events and 26% screened positive for depression and/or post-traumatic stress disorder. Participants were given personalized health reports and referred to services as needed. Information from the screenings will be used to inform the design of interventions targeting the West Side community and delivered in partnership with the churches. Sharing these results helped mobilize community members to improve their own health and the health of their community.
C1 [Lynch, Elizabeth B.] Rush Univ, Med Ctr, Dept Prevent Med, 1700 West Van Buren,Suite 470, Chicago, IL 60612 USA.
   [Williams, Joselyn; Avery, Elizabeth; Crane, Melissa M.; Lange-Maia, Brittney] Rush Univ, Med Ctr, Dept Prevent Med, Chicago, IL 60612 USA.
   [Tangney, Christy] Rush Univ, Med Ctr, Coll Hlth Sci, Dept Clin Nutr,Res, Chicago, IL 60612 USA.
   [Jenkins, LaDawne] Rush Univ, Med Ctr, Dept Community Engagement, Chicago, IL 60612 USA.
   [Dugan, Sheila A.] Rush Univ, Med Ctr, Dept Phys Med & Rehabil, Chicago, IL 60612 USA.
   [Emery-Tiburcio, Erin E.] Rush Univ, Med Ctr, Dept Psychiat & Behav Sci, Chicago, IL 60612 USA.
   [Epting, Steve M.] Hope Community Church, Chicago, IL 60651 USA.
C3 Rush University; Rush University; Rush University; Rush University; Rush
   University; Rush University
RP Lynch, EB (corresponding author), Rush Univ, Med Ctr, Dept Prevent Med, 1700 West Van Buren,Suite 470, Chicago, IL 60612 USA.
EM Elizabeth_lynch@rush.edu
OI Crane, Melissa/0000-0002-1458-2692; Emery-Tiburcio,
   Erin/0000-0002-6878-3369; Lynch, Elizabeth/0000-0003-0575-711X
FU National Heart, Lung and Blood Institute of the National Institutes of
   Health [R56HL135247]; Rush University Medical Center Department of
   Community Engagement; Foglia Family Foundation
FX We acknowledge the pastors, church coordinators and churches that
   participated in this study: Kandice Jones and Hope Community Church,
   Pastor Steve Spiller, Catherine Banks and Greater Galilee Missionary
   Baptist (MB) Church, Pastor Marshall Hatch, Rochelle Sykes, Gigi Fuller
   and New Mount Pilgrim MB Church, Pastor Cy Fields, Jessica Hudnall, and
   New Landmark MB Church, Pastor Ira Acree, Patty Ringo and Greater St.
   John Bible Church, Pastor Floyd James, Sr., Precious James and Greater
   Rock MB Church, and Pastor Michael Bryant, Tamara Gear and Kedvale New
   Mt. Zion MB Church. Numerous volunteers from each church also helped
   conduct the health screenings. In addition, numerous volunteers and
   staff from Rush University Medical Center helped with the screenings,
   including Wil Mims, Serena Sylvestri, and Shelby Gilyard. Research
   reported in this publication was supported by National Heart, Lung and
   Blood Institute of the National Institutes of Health under Award Number
   R56HL135247. The content is solely the responsibility of the authors and
   does not necessarily represent the official views of the National
   Institutes of Health. We would also like to thank Dr. David Ansell and
   Darlene Hightower and the Rush University Medical Center Department of
   Community Engagement for providing additional funding for this study.
   Funding was also provided by the Foglia Family Foundation.
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NR 45
TC 13
Z9 19
U1 0
U2 8
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0094-5145
EI 1573-3610
J9 J COMMUN HEALTH
JI J. Community Health
PD FEB
PY 2020
VL 45
IS 1
BP 98
EP 110
DI 10.1007/s10900-019-00715-9
PG 13
WC Health Policy & Services; Public, Environmental & Occupational Health
WE Social Science Citation Index (SSCI)
SC Health Care Sciences & Services; Public, Environmental & Occupational
   Health
GA KQ7PR
UT WOS:000517113200012
PM 31399892
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Chen, LC
   Chen, JW
   Wu, MH
   Liu, JC
   Lan, GY
   Ding, PYA
   Chang, MS
AF Chen, LC
   Chen, JW
   Wu, MH
   Liu, JC
   Lan, GY
   Ding, PYA
   Chang, MS
TI Differential coronary calcification on electron-beam CT between syndrome
   X and coronary artery disease in patients with chronic stable angina
   pectoris
SO CHEST
LA English
DT Article
DE coronary artery disease; coronary calcification; electron-beam CT;
   syndrome X
ID ULTRAFAST COMPUTED-TOMOGRAPHY; AMERICAN-HEART-ASSOCIATION; TERM
   FOLLOW-UP; CHEST PAIN; CALCIUM; EXERCISE; ARTERIOGRAMS; STRESS;
   QUANTIFICATION; ANGIOGRAMS
AB Study objectives: The differential diagnosis of syndrome X and coronary artery disease (CAD) in patients with evidence of myocardial ischemia may be difficult. The possible difference in coronary calcium detected by electron-beam CT (EBCT) between syndrome X and CAD is rarely evaluated, especially in aged patients with chronic, stable angina.
   Design and settings: Prospective, controlled study at a tertiary referral medical center.
   Patients and measurements: Forty patients with syndrome X (85% male) and 53 patients with CAD (89% male) were enrolled. Ten control subjects (90% male) with negative exercise treadmill test results and normal coronary angiographic findings served as control subjects. EBCT determined the coronary calcium scores (CCSs), and standard cardiovascular risk factors of all study subjects were analyzed.
   Results: The 93 study patients had CCSs that ranged from 0 to 1,857. Coronary calcification was seen in 2 of the 10 control subjects (20%),21 of the 40 syndrome X patients (52.5%), and 51 of the 53 CAD patients (96.2%) [p<0.01.]. The CCS (median [range]) was significantly lower in syndrome X patients than in CAD patients: 1 (0 to 117) vs 202 (0 to 1,857) [p<0.001]. Receiver operating characteristic curve analyses also demonstrated that coronary calcification differentiated syndrome X from CAD (area under curve, 0.891; 95% confidence interval, 0.806 to 0.947). Of the CAD patients whose CCSs were <117 and overlapped with CCSs of syndrome X multivariate analyses determined CCS >5 (odds ratio, 13.1; 95% confidence interval, 2.86 to 59.7), hypertension (odds ratio, 6.4; 95% confidence interval, 1.5 to 27.4), and hypercholesterolemia (odds ratio, 6.7; 95% confidence interval, 1.5 to 30.5) to be independent discriminators to differentiate CAD from syndrome X. Patients with CAD had more frequent hypertension than patients with syndrome X.
   Conclusions: The coronary calcium detected noninvasively by EBCT was different, though with some overlapping, between patients Kith syndrome X and CAD. In addition to standard cardiovascular risk factors, CCS determined by EBCT (especially >117 or = 0) could differentiate between syndrome X and CAD in patients with chronic, stable angina with evidence of myocardial ischemia. Larger trials would be useful to validate CCS on EBCT as a predictor of clinical outcome in these patients.
C1 Vet Gen Hosp, Dept Med, Div Cardiol, Taipei 11217, Taiwan.
   Natl Yang Ming Univ, Sch Med, Cardiovasc Res Ctr, Taipei 112, Taiwan.
   Vet Gen Hosp, Dept Radiol, Taipei, Taiwan.
   Taipei Med Univ, Div Cardiovasc Med, Taipei, Taiwan.
   Taipei Wan Fang Hosp, Taipei, Taiwan.
   Cheng Hsin Gen Hosp, Dept Med Imaging, Taipei, Taiwan.
C3 National Yang Ming Chiao Tung University; Taipei Medical University;
   Taipei Municipal WanFang Hospital; Cheng Hsin General Hospital
RP Chen, JW (corresponding author), Vet Gen Hosp, Dept Med, Div Cardiol, 201 Shih Pai Rd,Sect 2, Taipei 11217, Taiwan.
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NR 36
TC 8
Z9 8
U1 0
U2 1
PU AMER COLL CHEST PHYSICIANS
PI NORTHBROOK
PA 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 USA
SN 0012-3692
J9 CHEST
JI Chest
PD NOV
PY 2001
VL 120
IS 5
BP 1525
EP 1533
DI 10.1378/chest.120.5.1525
PG 9
WC Critical Care Medicine; Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Respiratory System
GA 494GW
UT WOS:000172274300022
PM 11713130
DA 2025-06-11
ER

PT J
AU Garduño-Diaz, SD
   Khokhar, S
AF Garduno-Diaz, S. D.
   Khokhar, S.
TI South Asian dietary patterns and their association with risk factors for
   the metabolic syndrome
SO JOURNAL OF HUMAN NUTRITION AND DIETETICS
LA English
DT Article
DE dietary acculturation; ethnicity; noncommunicable diseases; obesity;
   transition diet
ID PRINCIPAL-COMPONENTS-ANALYSIS; CORONARY-HEART-DISEASE; NONCOMMUNICABLE
   DISEASES; NUTRITION TRANSITION; CARDIOVASCULAR RISK; PHYSICAL-ACTIVITY;
   MENTAL-HEALTH; WOMEN; POPULATION; PREVALENCE
AB Background Certain dietary patterns have been associated with higher risk of noncommunicable diseases, with South Asians identified as a high-risk group. The present study aimed to identify the association between dietary patterns and the metabolic syndrome (MS) in South Asians living in the UK. Methods Dietary patterns were derived by principal component analysis from 15 different food groups using an ethnic-specific food frequency questionnaire. MS risk factors, including obesity and hypertension, were measured, whereas existing conditions of dyslipidaemia and hyperglycaemia were self-reported. Participants (n=100) were divided into quartiles based on dietary factor scores and the link between dietary patterns and risk factors was investigated. Results Three different patterns were derived, which together explained 46% of the total diet variation; eastern pattern, mixed pattern and western pattern. An inverse correlation was found between the eastern pattern and education P=0.05). A direct correlation was found between the western pattern and physical activity (P=0.05) and the overall risk of MS (P=0.05). Body composition was altered as residence time in the UK increased, with a reduction in muscle mass (2926%) and an increase in body fat (3137%). Diagnosis criteria for MS were found in 20% of the participants. Conclusions Dietary acculturation, including a reduction in vegetarianism, an increased intake of caffeinated drinks and altered meal patterns, may be associated with the higher prevalence of MS in migrant South Asians in the UK.
C1 [Garduno-Diaz, S. D.; Khokhar, S.] Univ Leeds, Sch Food Sci & Nutr, Leeds LS2 9JT, W Yorkshire, England.
C3 University of Leeds
RP Garduño-Diaz, SD (corresponding author), Univ Leeds, Sch Food Sci & Nutr, Leeds LS2 9JT, W Yorkshire, England.
EM fssdgd@leeds.ac.uk
FU Mexican National Council of Science and Technology (CONACYT)
FX SDGD thanks the Mexican National Council of Science and Technology
   (CONACYT) for PhD sponsorship. The authors would also like to
   acknowledge the European Food Information Resource Network (EuroFIR) and
   the Food Standards Agency for food composition data.
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NR 53
TC 45
Z9 52
U1 0
U2 43
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0952-3871
EI 1365-277X
J9 J HUM NUTR DIET
JI J. Hum. Nutr. Diet.
PD APR
PY 2013
VL 26
IS 2
BP 145
EP 155
DI 10.1111/j.1365-277X.2012.01284.x
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 107NN
UT WOS:000316224600004
PM 22943473
DA 2025-06-11
ER

PT J
AU Shah, D
   Singh, B
   Varnika, FNU
   Fredrick, FC
   Meda, AKR
   Aggarwal, K
   Jain, R
AF Shah, Darshini
   Singh, Bhupinder
   Varnika, F. N. U.
   Fredrick, Fremita Chelsea
   Meda, Anish Kumar Reddy
   Aggarwal, Kanishk
   Jain, Rohit
TI Linking hearts and minds: understanding the cardiovascular impact of
   bipolar disorder
SO FUTURE CARDIOLOGY
LA English
DT Review
DE bipolar disorder; cardiovascular disorder; heart brain axis; smoking;
   typical antipsychotics
ID MAJOR DEPRESSIVE DISORDER; SEVERE MENTAL-ILLNESS; METABOLIC SYNDROME;
   MYOCARDIAL-INFARCTION; RISK-FACTORS; DISEASE; PREVALENCE; MORTALITY;
   METAANALYSIS; ASSOCIATION
AB Bipolar disorder is a severe and recurring condition that has become a significant public health issue globally. Studies indicate a heightened risk and earlier onset of cardiovascular diseases among individuals with bipolar disorder, potentially increasing mortality rates. The chronic nature of bipolar disorder leads to disturbances across multiple systems, including autonomic dysfunction, over-activation of the hypothalamic-pituitary-adrenal axis and increased levels of peripheral inflammatory markers. These disruptions cause endothelial damage, the formation of plaques and blood clots, in addition to the medications used to treat bipolar disorder and genetic associations contributing to cardiovascular disease development. Understanding the complex interplay between bipolar disorder and cardiovascular events is essential for the prevention and effective management of cardiovascular conditions in individuals with bipolar disorder.
   PLAIN LANGUAGE SUMMARY
   Bipolar disorder is a mental health condition that affects mood and behavior, significantly impacting the lives of many people around the world. People with this disorder are also at a higher risk for heart diseases, including heart attacks and strokes. Certain lifestyle factors, common among people with bipolar disorder, such as smoking, poor diet and lack of exercise, can cause inflammation and stress, which damage blood vessels and increase the likelihood of heart conditions. The relationship between bipolar disorder and heart disease is complex. The condition affects how the body handles stress and can disrupt normal heart functions. For instance, stress from bipolar disorder can lead to high blood pressure and irregular heartbeats and certain medications taken by those with bipolar disorder can further damage the heart. To better manage these risks, it's important to understand the connection between bipolar disorder and heart disease. Future research should focus on creating guidelines for regular heart health check-ups for people with bipolar disorder and improving overall care to help prevent unfavorable outcomes.
C1 [Shah, Darshini] GCS Med Coll Hosp & Res Ctr, Dept Psychiat, Ahmadabad 380025, Gujarat, India.
   [Singh, Bhupinder] NYC Hlth Hosp Queens, Icahn Sch Med Mt Sinai, Dept Med, New York, NY 11432 USA.
   [Varnika, F. N. U.] Maharishi Markandeshwar Inst Med Sci & Res, Dept Med, Mullana 133207, India.
   [Fredrick, Fremita Chelsea; Meda, Anish Kumar Reddy] Avalon Univ, Dept Med, Sch Med, Willemstad, Curacao.
   [Aggarwal, Kanishk] Dayanand Med Coll & Hosp, Ludhiana 141001, India.
   [Jain, Rohit] Penn State Hlth Milton S Hershey Med Ctr, Hershey, PA 17033 USA.
C3 Icahn School of Medicine at Mount Sinai; Maharishi Markandeshwar
   University; Dayanand Medical College & Hospital; Pennsylvania
   Commonwealth System of Higher Education (PCSHE); Pennsylvania State
   University; Penn State Health
RP Varnika, FNU (corresponding author), Maharishi Markandeshwar Inst Med Sci & Res, Dept Med, Mullana 133207, India.
EM varnikafnu@gmail.com
RI Aggarwal, Kanishk/MBV-6086-2025; Shah, Darshini/KHZ-4975-2024; Singh,
   Bhupinder/JFS-4057-2023
OI Shah, Darshini/0009-0003-2175-2877; Singh,
   Bhupinder/0009-0004-9218-0885; Meda, Anish Kumar
   Reddy/0009-0008-2008-5992; Fredrick, Fremita/0009-0002-3341-7251;
   Aggarwal, Kanishk/0009-0005-7518-446X
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NR 89
TC 2
Z9 2
U1 3
U2 4
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1479-6678
EI 1744-8298
J9 FUTUR CARDIOL
JI Futur. Cardiol.
PD OCT 2
PY 2024
VL 20
IS 13
BP 709
EP 718
DI 10.1080/14796678.2024.2408944
EA OCT 2024
PG 10
WC Cardiac & Cardiovascular Systems
WE Emerging Sources Citation Index (ESCI)
SC Cardiovascular System & Cardiology
GA L3Y8H
UT WOS:001329449500001
PM 39382013
DA 2025-06-11
ER

PT J
AU Zecchinati, F
   Barranco, MM
   Arana, MR
   Tocchetti, GN
   Domínguez, CJ
   Perdomo, VG
   Ruiz, ML
   Mottino, AD
   García, F
   Villanueva, SSM
AF Zecchinati, Felipe
   Manuela Barranco, Maria
   Rocio Arana, Maite
   Nicolas Tocchetti, Guillermo
   Juliana Dominguez, Camila
   Gabriela Perdomo, Virginia
   Laura Ruiz, Maria
   Domingo Mottino, Aldo
   Garcia, Fabiana
   Maris Villanueva, Silvina Stella
TI Reversion of down-regulation of intestinal multidrug
   resistance-associated protein 2 in fructose-fed rats by geraniol and
   vitamin C: Potential role of inflammatory response and oxidative stress
SO JOURNAL OF NUTRITIONAL BIOCHEMISTRY
LA English
DT Article
DE Fructose-rich diet; Metabolic syndrome; Insulin resistance; Intestine;
   Mrp2; Oxidative stress; Inflammation
ID VIVO INSULIN-RESISTANCE; METABOLIC SYNDROME; SUPEROXIDE-DISMUTASE;
   ANTIOXIDANT STATUS; RICH DIET; EXPRESSION; LIVER; PREVENTS;
   FRUCTOKINASE; INVOLVEMENT
AB Intestinal multidrug resistance-associated protein 2 is an ABC transporter that limits the absorption of xenobiotics ingested orally, thus acting as essential component of the intestinal biochemical barrier. Metabolic Syndrome (MetS) is a pathological condition characterized by dyslipidemia, hyperinsulinemia, insulin resistance, chronic inflammation, and oxidative stress (OS). In a previous study we demonstrated that MetS-like conditions induced by fructose in drinking water (10% v/v, during 21 days), significantly reduced the expression and activity of intestinal Mrp2 in rats. We here evaluated the potential beneficial effect of geraniol or vitamin C supplementation, natural compounds with anti-inflammatory and anti-oxidant properties, in reverse fructose-induced Mrp2 alterations. After MetS-like conditions were induced (21 days), animals were cotreated with geraniol or vitamin C or vehicle for another 14 days. Decreased expression of Mrp2 protein and mRNA due to fructose administration was reversed by geraniol and by vitamin C, consistent with restoration of Mrp2 activity evaluated in everted intestinal sacs. Concomitantly, increased intestinal IL-1 beta and IL-6 levels induced by fructose were totally and partially counterbalanced, respectively, by geraniol administration. The intestinal redox unbalance generated by fructose was improved by geraniol and vitamin C, as evidenced by decreasing lipid peroxidation products and activity of Superoxide Dismutase and by normalizing glutathione reduced/oxidized glutathione ratio. The restoration effects exhibited by geraniol and vitamin C suggest that local inflammatory response and OS generated under MetS-like conditions represent important mediators of the intestinal Mrp2 down-regulation. Additionally, both agents could be considered of potential therapeutic value to preserve Mrp2 function under MetS conditions. (C) 2019 Published by Elsevier Inc.
C1 [Zecchinati, Felipe; Rocio Arana, Maite; Nicolas Tocchetti, Guillermo; Juliana Dominguez, Camila; Laura Ruiz, Maria; Domingo Mottino, Aldo; Maris Villanueva, Silvina Stella] Univ Nacl Rosario, Inst Fisiol Expt IFISE CONICET, Fac Ciencias Bioquim & Farmaceut, Rosario, Santa Fe, Argentina.
   [Manuela Barranco, Maria; Garcia, Fabiana] Univ Nacl Rosario, CONICET, Fac Ciencias Med, Lab Fisiol Metab, Rosario, Santa Fe, Argentina.
   [Gabriela Perdomo, Virginia] Univ Nacl Rosario, Inst Biol Mol & Celular Rosario IBR CONICET, Fac Ciencias Bioquim & Farmaceut, Rosario, Santa Fe, Argentina.
C3 National University of Rosario; Consejo Nacional de Investigaciones
   Cientificas y Tecnicas (CONICET); Consejo Nacional de Investigaciones
   Cientificas y Tecnicas (CONICET); National University of Rosario;
   National University of Rosario; Consejo Nacional de Investigaciones
   Cientificas y Tecnicas (CONICET)
RP Villanueva, SSM (corresponding author), UNR, CONICET, Inst Fisiol Expt, Fac Ciencias Bioquim & Farmaceut, Suipacha 570, RA-2000 Rosario, Santa Fe, Argentina.
EM villanueva@ifise-conicet.gov.ar
RI Perdomo, Virginia/JMP-4098-2023
OI Tocchetti, Guillermo Nicolas/0000-0003-3884-0980; Perdomo, Virginia
   Gabriela/0009-0006-3087-7630
FU Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET)
   [PIP 2015-0202]; Fondo para la Investigacion Cientifica y Tecnologica
   (FONCyT) [PICT 2014-1121, PICT 2014-0476]
FX This study was supported by grants from: Consejo Nacional de
   Investigaciones Cientificas y Tecnicas (CONICET) [PIP 2015-0202], Fondo
   para la Investigacion Cientifica y Tecnologica (FONCyT) [PICT 2014-1121
   (to S.S.M.V.) and PICT 2014-0476 (to A.D.M.)].
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NR 64
TC 13
Z9 15
U1 0
U2 11
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0955-2863
EI 1873-4847
J9 J NUTR BIOCHEM
JI J. Nutr. Biochem.
PD JUN
PY 2019
VL 68
BP 7
EP 15
DI 10.1016/j.jnutbio.2019.03.002
PG 9
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA ID5SR
UT WOS:000471736800002
PM 31005848
OA Green Published
DA 2025-06-11
ER

PT J
AU Alifu, J
   Xu, B
   Tuersun, G
   Liu, L
   Xiang, LQ
   Mohammed, AQ
   Zhang, W
   Yin, GQ
   Wang, CY
   Lv, X
   Shi, TT
   Wu, Q
   Abdu, FA
   Che, WL
AF Alifu, Jiasuer
   Xu, Bin
   Tuersun, Guliziba
   Liu, Lu
   Xiang, Lanqing
   Mohammed, Abdul-Quddus
   Zhang, Wen
   Yin, Guoqing
   Wang, Chunyue
   Lv, Xian
   Shi, Tingting
   Wu, Qian
   Abdu, Fuad A.
   Che, Wenliang
TI The prognostic significance of stress hyperglycemia ratio for all-cause
   and cardiovascular mortality in metabolic syndrome patients: prospective
   cohort study
SO ACTA DIABETOLOGICA
LA English
DT Article
DE Metabolic syndrome; Stress hyperglycemia ratio; Mortality; NHANES
ID MYOCARDIAL-INFARCTION; RISK; EVENTS
AB Objective The stress hyperglycemia ratio (SHR) is a new biomarker indicating acute hyperglycemia and predicting adverse outcomes in different conditions. Yet, its impact on metabolic syndrome (MetS) has not been studied. We explored the link between SHR and long-term all-cause and cardiovascular disease (CVD) mortality in MetS patients. Methods We conducted a large prospective cohort study involving 9438 participants diagnosed with MetS, drawn from the 1999-2018 NHANES. MetS diagnosis was based on NCEP-ATPIII criteria. Participants were categorized into three groups based on SHR tertiles: T1 (SHR <= 0.890), T2 (SHR 0.890-0.992), and T3 (SHR >= 0.992). Cox regression and Kaplan-Meier curve analyses assessed the correlation between SHR and mortalities. Non-linear correlations were explored using restricted cubic splines, and stratification analysis was performed. Results Out of 9438 MetS patients, 1929 deaths occurred during an average follow-up of 107 +/- 64 months, including 541 CVD deaths. All-cause and CVD mortality rates were significantly higher with elevated SHR values (T3) than lower tertiles (23.4% vs. 19.5% and 18.3%, P < 0.001; 6.8% vs. 5.3% and 5.1%, P = 0.007, respectively). A U-shaped relationship was observed between SHR and all-cause and CVD mortality (all P for non-linear < 0.001). Kaplan-Meier analysis indicated higher SHR values associated with increased risk of all-cause and CVD mortality (all log-rank P < 0.001). After adjusting for confounders, multivariate Cox regression showed SHR remained associated with a 1.256-fold and 1.023-fold risk of all-cause and CVD mortality. Conclusions SHR independently correlates with all-cause and CVD mortality in MetS patients, displaying a U-shaped relationship with clinical endpoints.
C1 [Alifu, Jiasuer; Xu, Bin; Liu, Lu; Xiang, Lanqing; Mohammed, Abdul-Quddus; Zhang, Wen; Yin, Guoqing; Wang, Chunyue; Lv, Xian; Shi, Tingting; Abdu, Fuad A.; Che, Wenliang] Tongji Univ, Sch Med, Shanghai Peoples Hosp 10, Dept Cardiol, 301 Yanchang Rd, Shanghai 200072, Peoples R China.
   [Xu, Bin] Fudan Univ, Shanghai Xuhui Cent Hosp, Zhongshan Xuhui Hosp, Dept Cardiol, Shanghai, Peoples R China.
   [Tuersun, Guliziba] Peoples Hosp Xinjiang Uygur Autonomous Reg, Xinjiang Clin Res Ctr Dermatol & Venereol, Dept Dermatol & Venereol, Xinjiang Key Lab Dermatol Res, Urumqi, Xinjiang, Peoples R China.
   [Xiang, Lanqing] Nanjing Med Univ, Clin Med Coll, Shanghai Peoples Hosp 10, Dept Cardiol, Shanghai, Peoples R China.
   [Wu, Qian] Soochow Univ, Affiliated Hosp 1, Orthoped Inst, Dept Orthoped Surg, 188 Shizijie Rd, Suzhou 215006, Jiangsu, Peoples R China.
   [Wu, Qian] Jeonbuk Natl Univ, Med Sch, Res Inst Clin Med, Jeonju, South Korea.
   [Che, Wenliang] Shanghai Tenth Peoples Hosp, Chongming Branch, Dept Cardiol, Shanghai, Peoples R China.
C3 Tongji University; Fudan University; Nanjing Medical University; Soochow
   University - China; Jeonbuk National University
RP Abdu, FA; Che, WL (corresponding author), Tongji Univ, Sch Med, Shanghai Peoples Hosp 10, Dept Cardiol, 301 Yanchang Rd, Shanghai 200072, Peoples R China.; Wu, Q (corresponding author), Soochow Univ, Affiliated Hosp 1, Orthoped Inst, Dept Orthoped Surg, 188 Shizijie Rd, Suzhou 215006, Jiangsu, Peoples R China.; Wu, Q (corresponding author), Jeonbuk Natl Univ, Med Sch, Res Inst Clin Med, Jeonju, South Korea.; Che, WL (corresponding author), Shanghai Tenth Peoples Hosp, Chongming Branch, Dept Cardiol, Shanghai, Peoples R China.
EM qianwujoint@163.com; 1691026@tongji.edu.cn; chewenliang@tongji.edu.cn
RI MOHAMMED, ABDUL QUDDUS/KBA-9659-2024; Wu, Qian/KVB-0410-2024
OI Wu, Qian/0000-0002-3986-6042
FU Chinese National Natural Science Foundation
FX The authors are indebted to all members who contributed to the NHANES
   study.
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NR 34
TC 2
Z9 2
U1 4
U2 6
PU SPRINGER-VERLAG ITALIA SRL
PI MILAN
PA VIA DECEMBRIO, 28, MILAN, 20137, ITALY
SN 0940-5429
EI 1432-5233
J9 ACTA DIABETOL
JI Acta Diabetol.
PD JUN
PY 2025
VL 62
IS 6
BP 903
EP 913
DI 10.1007/s00592-024-02407-w
EA NOV 2024
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 3LJ0U
UT WOS:001350904500003
PM 39508855
DA 2025-06-11
ER

PT J
AU Reijrink, M
   De Boer, SA
   Van Roon, AM
   Slart, RHJA
   Fernandez, BO
   Feelisch, M
   Heerspink, HJL
   Van Goor, H
   Hillebrands, JL
   Mulder, DJ
AF Reijrink, Melanie
   De Boer, Stefanie A.
   Van Roon, Anniek M.
   Slart, Riemer H. J. A.
   Fernandez, Bernadette O.
   Feelisch, Martin
   Heerspink, Hiddo J. L.
   Van Goor, Harry
   Hillebrands, Jan-Luuk
   Mulder, Douwe J.
TI Plasma Nitrate Levels Are Related to Metabolic Syndrome and Are Not
   Altered by Treatment with DPP-4 Inhibitor Linagliptin: A Randomised,
   Placebo-Controlled Trial in Patients with Early Type 2 Diabetes Mellitus
SO ANTIOXIDANTS
LA English
DT Article
DE diabetes; inflammation; linagliptin; metabolic syndrome; nitrate; nitric
   oxide; oxidative stress; vegetable intake
ID NITRIC-OXIDE; OXIDATIVE STRESS; INSULIN-RESISTANCE; ADIPOSE-TISSUE;
   ARTERIAL STIFFNESS; DIETARY NITRITE; INFLAMMATION; OBESITY;
   COMPLICATIONS; PATHOGENESIS
AB The depletion of nitrate and nitrite, stable nitric oxide (NO) end-products, promotes adipose tissue dysfunction and insulin resistance (IR). Dipeptidyl peptidase-4 (DPP-4) inhibitors have the potentially beneficial side effect of increasing NO availability. In this study, nitrate and nitrite levels and the effects of DPP-4 inhibitor linagliptin were investigated in relation to metabolic syndrome (MetS) markers. Treatment-naive patients with early type 2 diabetes mellitus (T2DM) (n = 40, median age 63 IQR (55-67) years, 63% male, mean HbA1c 45 +/- 4.4 mmol/mol) were randomized (1:1) to linagliptin (5 mg/day) or placebo. MetS-related markers (body mass index (BMI), triglycerides, HOMA-IR, gamma-glutamyltransferase (GGT), C-reactive protein (CRP), and adiponectin), plasma levels of nitrate, nitrite, total free thiols (TFT) and vegetable intake were estimated at baseline and after 4 and 26 weeks of treatment. Plasma nitrate, but not nitrite, correlated positively with vegetable intake (r = 0.38, p = 0.018) and was inversely associated with HOMA-IR (r = -0.44, p = 0.006), BMI (r = -0.35, p = 0.028), GGT (r = -0.37, p = 0.019) and CRP (r = -0.34, p = 0.034). The relationship between nitrate and HOMA-IR remained significant after adjusting for BMI, CRP, vegetable intake and GGT. With stable vegetable intake, nitrate and nitrite, TFT, adipokines and CRP did not change after 26 weeks of linagliptin treatment. While plasma nitrate is inversely associated with MetS, linagliptin treatment does not significantly influence nitrate and nitrite concentrations, oxidative stress, adipose tissue function and systemic inflammation.
C1 [Reijrink, Melanie; De Boer, Stefanie A.; Van Roon, Anniek M.; Mulder, Douwe J.] Univ Groningen, Div Vasc Med, Dept Internal Med, Med Ctr Groningen, NL-9713 Groningen, Netherlands.
   [Slart, Riemer H. J. A.] Univ Groningen, Dept Nucl Med & Mol Imaging, Med Ctr Groningen, NL-9713 Groningen, Netherlands.
   [Slart, Riemer H. J. A.] Univ Twente, Dept Biomed Photoacust Imaging BMPI, NL-7522 Enschede, Netherlands.
   [Fernandez, Bernadette O.; Feelisch, Martin] Univ Southampton, Fac Med Clin & Expt Sci, Southampton SO17 1BJ, Hants, England.
   [Heerspink, Hiddo J. L.] Univ Groningen, Dept Clin Pharm & Pharmacol, Med Ctr Groningen, NL-9713 Groningen, Netherlands.
   [Van Goor, Harry; Hillebrands, Jan-Luuk] Univ Groningen, Div Pathol, Dept Pathol & Med Biol, Med Ctr Groningen, NL-9713 Groningen, Netherlands.
C3 University of Groningen; University of Groningen; University of
   Southampton; University of Groningen; University of Groningen
RP Mulder, DJ (corresponding author), Univ Groningen, Div Vasc Med, Dept Internal Med, Med Ctr Groningen, NL-9713 Groningen, Netherlands.
EM r.h.j.a.slart@umcg.nl; h.j.lambers.heerspink@umcg.nl
RI van+Goor, Harry/AAS-7712-2020; Fernandez, Bernadette/AAG-7202-2020;
   Feelisch, Martin/C-3042-2008; Lambers Heerspink, Hiddo/K-3358-2014
OI van Goor, Harry/0000-0002-6670-1577; de Boer,
   Stefanie/0000-0002-7532-2536; Feelisch, Martin/0000-0003-2320-1158;
   Fernandez, Bernadette/0000-0001-6337-0381; Mulder,
   Douwe/0000-0003-3715-6474; Lambers Heerspink, Hiddo/0000-0002-3126-3730;
   Slart, Riemer/0000-0002-5565-1164; Reijrink, Melanie/0000-0001-9447-7333
FU Boehringer Ingelheim (Alkmaar, the Netherlands); MD/PhD program of the
   Graduate School of Medical Sciences (GSMS), University Medical Centre
   Groningen
FX This study was supported by Boehringer Ingelheim (Alkmaar, the
   Netherlands). Boehringer Ingelheim was not involved in the design and
   results of the study; collection, management, analysis and
   interpretation of data, writing of the report or the decision to submit
   the paper for publication. M.R. was supported by the MD/PhD program of
   the Graduate School of Medical Sciences (GSMS), University Medical
   Centre Groningen.
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NR 54
TC 2
Z9 2
U1 0
U2 1
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD OCT
PY 2021
VL 10
IS 10
AR 1548
DI 10.3390/antiox10101548
PG 11
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA WO4GU
UT WOS:000712415300001
PM 34679685
OA Green Accepted, gold, Green Published
DA 2025-06-11
ER

PT J
AU Puchau, B
   Zulet, MA
   de Echávarri, AG
   Hermsdorff, HHM
   Martínez, JA
AF Puchau, Blanca
   Angeles Zulet, M.
   Gonzalez de Echavarri, Amaia
   Miranda Hermsdorff, Helen Hermana
   Alfredo Martinez, J.
TI Dietary total antioxidant capacity is negatively associated with some
   metabolic syndrome features in healthy young adults
SO NUTRITION
LA English
DT Article
DE Oxidative stress; Antioxidant intake; Inflammation; Food-frequency
   questionnaire; Systolic blood pressure; Complement factor-3; Plasminogen
   activator inhibitor-1
ID FOOD-FREQUENCY QUESTIONNAIRE; SPECIES ROS GENERATION; OXIDATIVE STRESS;
   INSULIN-RESISTANCE; WINE CONSUMPTION; SELENIUM INTAKE; BLOOD-PRESSURE;
   FOLLOW-UP; RED WINE; PLASMA
AB Objective: Oxidative stress has been related to the development of obesity and other features accompanying chronic diseases Furthermore, dietary antioxidant intake has been suggested to protect against oxidative damage and related clinical complications Therefore, the aim of this study was to assess the potential associations among dietary total antioxidant capacity (TAC) and several early metabolic syndrome manifestations in healthy young adults.
   Methods: Anthropometric variables and blood pressure from 153 healthy subjects (20 8 +/- 27 y old) were measured Dietary intake was assessed by a validated food-frequency questionnaire and a 3-d record, which were also used to calculate TAC and to adjust by daily energy intake. Fasting blood samples were collected for measuring biochemical markers.
   Results: Dietary TAC showed positive and significant associations with fiber, folic acid, vitamin A and C. magnesium, selenium, and zinc intakes, after adjusting by sex and daily energy intake Interestingly, systolic blood pressure, serum glucose. and free fatty acids were also found to be negatively associated with dietary TAC independently of sex and daily energy intake Also, a relevant relation was found between body mass index and TAC values. Interestingly, after adjusting by sex and daily enemy intake, complement factor-3 circulating levels appeared to be negatively and significantly associated with dietary TAC, whereas blood plasminogen activator inhibitor-1 and homocysteine concentrations showed an Inverse marginally statistical trend.
   Conclusions: These data suggest that dietary TAC may be also a potential early estimate of the risk to develop metabolic syndrome features and that dietary TAC could be a useful research tool in assessing antioxidant intake (C) 2010 Elsevier Inc. All rights reserved
C1 [Puchau, Blanca; Angeles Zulet, M.; Gonzalez de Echavarri, Amaia; Miranda Hermsdorff, Helen Hermana; Alfredo Martinez, J.] Univ Navarra, Dept Nutr Food Sci Physiol & Toxicol, E-31080 Pamplona, Spain.
C3 University of Navarra
RP Martínez, JA (corresponding author), Univ Navarra, Dept Nutr Food Sci Physiol & Toxicol, E-31080 Pamplona, Spain.
RI Martinez Hernandez, J Alfredo/K-8709-2014; Zulet, M.
   Angeles/H-1317-2017; Hermsdorff, Helen Hermana Miranda/H-4525-2015
OI Martinez Hernandez, J Alfredo/0000-0001-5218-6941; Zulet, M.
   Angeles/0000-0002-3926-0892; Hermsdorff, Helen Hermana
   Miranda/0000-0002-4441-6572
FU Health Department of the Government of Navarra [22/2007]; Linea Especial
   about Nutrition, Obesity and Health [LE/97]; University of Navarra;
   Capes Foundation of the Ministry of Education of Brazil [375605-0]
FX This work was supported by the Health Department of the Government of
   Navarra (22/2007), the Linea Especial about Nutrition, Obesity and
   Health (LE/97). Ibercaja, the ADA fellowships scheme of the University
   of Navarra and The Capes Foundation of the Ministry of Education of
   Brazil (375605-0)
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NR 53
TC 137
Z9 149
U1 0
U2 15
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0899-9007
EI 1873-1244
J9 NUTRITION
JI Nutrition
PD MAY
PY 2010
VL 26
IS 5
BP 534
EP 541
DI 10.1016/j.nut.2009.06.017
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 589HY
UT WOS:000277139000011
PM 19783122
DA 2025-06-11
ER

PT J
AU Kuoch, T
   Scully, M
   Tan, HK
   Rajan, TV
   Wagner, J
AF Kuoch, Theanvy
   Scully, Mary
   Tan, Heang Kim
   Rajan, Thiruchandurai V.
   Wagner, Julie
TI The National Cambodian American Town Hall Meeting: A Community Dialogue
   on "Eat, Walk, Sleep" for Health
SO PROGRESS IN COMMUNITY HEALTH PARTNERSHIPS-RESEARCH EDUCATION AND ACTION
LA English
DT Article
DE CBPR; metabolic syndrome; refugee; Cambodian
ID REFUGEES 2 DECADES; MENTAL-HEALTH; OUTCOMES; BELIEFS
AB Background: The 2009 National Cambodian American Town Hall Meeting was a public private partnership convened to address long-term health issues related the Cambodian holocaust. Goals for participants were to dispel myths about diabetes; goals for the partnership were to build research capacity and to strengthen relationships.
   Methods: Partners collaborated on all aspects of the meeting which was held in Khmer by bridged videoconferencing in 10 sites and webinar at 5 sites across the United States over a 3-hour period. EAT, WALK, SLEEP for Health (EWS), the National Cambodian American Diabetes Project program, provided the framework for the meeting.
   Results: Pre and post surveys were completed by 323 participants. Modest improvements were seen in participants' belief that they could improve their own and their community's health, although significant barriers remained. Participants and community partners evaluated the meeting positively.
   Conclusions: The meeting is a model for other populations, and results inform future work.
C1 [Kuoch, Theanvy; Scully, Mary] Khmer Hlth Advocates, Hartford, CT 06110 USA.
   [Rajan, Thiruchandurai V.; Wagner, Julie] Univ Connecticut, Ctr Hlth, Storrs, CT USA.
   [Tan, Heang Kim] Soc New Commun Res Inc, Hlth Justice CT, New York, NY USA.
C3 University of Connecticut
RP Kuoch, T (corresponding author), Khmer Hlth Advocates, Hartford, CT 06110 USA.
CR [Anonymous], DATA SET 2005 AMERIC
   [Anonymous], 2012, UNIVERSITY OF CONNEC, V1
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NR 13
TC 9
Z9 9
U1 0
U2 7
PU JOHNS HOPKINS UNIV PRESS
PI BALTIMORE
PA JOURNALS PUBLISHING DIVISION, 2715 NORTH CHARLES ST, BALTIMORE, MD
   21218-4363 USA
SN 1557-0541
EI 1557-055X
J9 PROG COMM HLTH PARTN
JI Prog. Community Health Partnersh.
PD WIN
PY 2014
VL 8
IS 4
BP 541
EP 547
DI 10.1353/cpr.2014.0068
PG 7
WC Public, Environmental & Occupational Health
WE Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA CD5HF
UT WOS:000351117900014
PM 25727987
DA 2025-06-11
ER

PT J
AU Karaman, A
   Aydin, H
   Geçkinli, B
   Çetinkaya, A
   Karaman, S
AF Karaman, Ali
   Aydin, Hatip
   Geckinli, Bilge
   Cetinkaya, Arda
   Karaman, Selin
TI DNA damage is increased in lymphocytes of patients with metabolic
   syndrome
SO MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
LA English
DT Article
DE Metabolic syndrome; DNA damage; Comet assay; Micronucleus assay
ID POLYCYSTIC-OVARY-SYNDROME; TYPE-2 DIABETIC-PATIENTS; POOR GLYCEMIC
   CONTROL; OXIDATIVE STRESS; LIPID-PEROXIDATION; ANTIOXIDANT CAPACITY;
   INSULIN-RESISTANCE; PERIPHERAL-BLOOD; FREE-RADICALS; ASSAY
AB We assessed DNA damage in patients with metabolic syndrome (MetS) by performing comet and micronucleus (MN) assays on peripheral blood lymphocyte cultures from study participants. 52 MetS patients and 35 age-matched healthy controls were evaluated for abdominal obesity, body-mass index (BMI), blood pressure, serum triglycerides, HbA1c, HDL-C, and fasting blood glucose levels. In addition, malondialdehyde (MDA) levels and activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) were determined. Serum levels of triglycerides, HbA1c, fasting blood glucose and waist circumference, systolic blood pressure, diastolic blood pressure, and BMI of the subjects in the MetS group were significantly higher than those of the control group (for each, p < 0.001). However, the mean level of HDL-C in the MetS group was lower than in the control group (p < 0.001). In the study, the length of comet tails was significantly higher in the MetS patients (10.23 +/- 1.98, range 5.72-15.08) than in the controls (3.12 +/- 1.73, range 0.6-7.1) (p < 0.001). MN frequency was also significantly increased in MetS patients (3.68 +/- 1.27 per 1000 cells) compared to that of the control group (1.81 +/- 0.84 per 1000 cells) (p < 0.001). Micronucleated cell frequency and comet-tail length in subjects showed positive correlations with waist circumference, BMI, and plasma triglyceride levels (p < 0.01) and negative correlations with HDL-C levels (p < 0.01). Among the oxidative stress factors, MDA levels were significantly higher in MetS patients than in the controls. However, SOD and GSH-Px enzyme activities were significantly lower in the MetS group than in the controls. These findings suggest that patients with MetS have increased DNA damage and oxidative stress. (C) 2015 Elsevier B.V. All rights reserved.
C1 [Karaman, Ali; Aydin, Hatip; Geckinli, Bilge; Cetinkaya, Arda] Istanbul Zeynep Kamil Women & Children Training &, Dept Med Genet, Istanbul, Turkey.
   [Karaman, Selin] Istanbul Dr Lutfi Kirdar Kartal Training & Res Ho, Dept Family Med, Istanbul, Turkey.
C3 Istanbul Zeynep Kamil Maternity & Children's Diseases Training &
   Research Hospital; Istanbul Kartal Dr Lutfi Kirdar Training & Research
   Hospital
RP Karaman, A (corresponding author), Istanbul Zeynep Kamil Women & Children Training &, Dept Med Genet, Istanbul, Turkey.
EM alikaramandr@hotmail.com
RI Geckinli, Bilge/AGY-3825-2022; aydin, hatip/AAE-5540-2021; CETINKAYA,
   ARDA/I-9547-2013; Karaman, Ali/V-5164-2019
OI Karaman, Ali/0000-0003-3425-2727
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NR 45
TC 40
Z9 45
U1 0
U2 16
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1383-5718
EI 1879-3592
J9 MUTAT RES-GEN TOX EN
JI Mutat. Res. Genet. Toxicol. Environ. Mutagen.
PD APR
PY 2015
VL 782
BP 30
EP 35
DI 10.1016/j.mrgentox.2015.03.009
PG 6
WC Biotechnology & Applied Microbiology; Genetics & Heredity; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Genetics & Heredity; Toxicology
GA CH0XW
UT WOS:000353746700005
PM 25868129
DA 2025-06-11
ER

PT J
AU de Rezende, LFM
   Rey-López, JP
   Matsudo, VKR
   Luiz, OD
AF Machado de Rezende, Leandro Fornias
   Rey-Lopez, Juan Pablo
   Rodrigues Matsudo, Victor Keihan
   Luiz, Olinda do Carmo
TI Sedentary behavior and health outcomes among older adults: a systematic
   review
SO BMC PUBLIC HEALTH
LA English
DT Review
DE Sedentary lifestyle; Sitting time; Television; Risk factors; Aged;
   Health status; Mortality
ID ASSESSED PHYSICAL-ACTIVITY; TELEVISION VIEWING TIME; SITTING TIME;
   METABOLIC SYNDROME; CARDIOVASCULAR-DISEASE; RISK; ASSOCIATIONS;
   INDICATORS; MORTALITY; OBESITY
AB Background: In the last decade, sedentary behavior has emerged as a new risk factor for health. The elderly spend most of their awake time in sedentary activities. Despite this high exposure, the impact of this sedentary behavior on the health of this population has not yet been reviewed. We systematically reviewed evidence for associations between sedentary behavior and multiple health outcomes in adults over 60 years of age.
   Methods: We searched the Medline, Embase, Web of Science, SPORTDiscus, PsycINFO, CINAHL, LILLACS, and Sedentary Research Database for observational studies published up to May 2013. Additionally, we contacted members of the Sedentary Behaviour Research Network to identify articles that were potentially eligible. After inclusion, the methodological quality of the evidence was assessed in each study.
   Results: We included 24 eligible articles in our systematic review, of which only 2 (8%) provided high-quality evidence. Greater sedentary time was related to an increased risk of all-cause mortality in the older adults. Some studies with a moderate quality of evidence indicated a relationship between sedentary behavior and metabolic syndrome, waist circumference, and overweightness/obesity. The findings for other outcomes such as mental health, renal cancer cells, and falls remain insufficient to draw conclusions.
   Conclusion: This systematic review supports the relationship between sedentary behavior and mortality in older adults. Additional studies with high methodological quality are still needed to develop informed guidelines for addressing sedentary behavior in older adults.
C1 [Machado de Rezende, Leandro Fornias; Rey-Lopez, Juan Pablo; Luiz, Olinda do Carmo] Univ Sao Paulo, Sch Med, Dept Prevent Med, Sao Paulo, Brazil.
   [Machado de Rezende, Leandro Fornias; Rodrigues Matsudo, Victor Keihan] Ctr Studies & Phys Fitness Lab Sao Caetano do Sul, Sao Caetano do Sul, SP, Brazil.
C3 Universidade de Sao Paulo
RP de Rezende, LFM (corresponding author), Univ Sao Paulo, Sch Med, Dept Prevent Med, Av Dr Arnaldo 455, Sao Paulo, Brazil.
EM lerezende@usp.br
RI Luiz, Olinda/C-6075-2012; Rezende, Leandro/C-1724-2012
OI Rezende, Leandro/0000-0002-7469-1399; Rey Lopez, Juan
   Pablo/0000-0002-7201-2006
FU Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP, Sao Paulo
   Research Foundation) [2012/07314-8]
FX We would like to thank the Sedentary Behaviour Research Network members
   for sending us titles of studies that were potentially eligible for
   inclusion in our systematic review. This study received financial
   support from the Fundacao de Amparo a Pesquisa do Estado de Sao Paulo
   (FAPESP, Sao Paulo Research Foundation; Grant no. 2012/07314-8).
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NR 61
TC 430
Z9 497
U1 12
U2 123
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2458
J9 BMC PUBLIC HEALTH
JI BMC Public Health
PD APR 9
PY 2014
VL 14
AR 333
DI 10.1186/1471-2458-14-333
PG 9
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA AG5PB
UT WOS:000335469800001
PM 24712381
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Attia, GM
   Alharbi, OA
   Aljohani, RM
AF Attia, Ghalia M.
   Alharbi, Ohood A.
   Aljohani, Reema M.
TI The Impact of Irregular Menstruation on Health: A Review of the
   Literature
SO CUREUS JOURNAL OF MEDICAL SCIENCE
LA English
DT Review
DE psychological and mental health; infertility; osteoporosis; anemia;
   quality of life; rheumatoid arthritis; cardiovascular diseases; type 2
   diabetes mellitus; metabolism syndrome; irregular menstruation
ID POLYCYSTIC-OVARY-SYNDROME; METABOLIC SYNDROME; CYCLE IRREGULARITY;
   ADOLESCENTS; DISORDERS; WOMEN; ASSOCIATION; RISK; UNIVERSITY; STUDENTS
AB Women are considered to have an irregular menstrual cycle if their cycle length is less than 21 days or more than 35 days, accompanied by less or very severe blood flow. The prevalence of menstrual cycle irregularities varies across countries. Irregular periods can occur due to changes in the body's levels of estrogen and progesterone hormones, which disrupt the normal pattern of the period. Menstrual irregularity has been found to be associated with various diseases and medical conditions, such as metabolic syndrome, coronary heart disease, type 2 diabetes mellitus, and rheumatoid arthritis. Anemia, osteoporosis, psychological problems, impaired quality of life, and infertility have also been recorded. Moreover, a significant correlation between irregular periods and the risk of developing pregnancy-related hypertensive disorders, as well as an increased risk of adverse obstetric and neonatal outcomes, has been proven. Therefore, irregular menstruation is considered an important health indicator among women. Physical, mental, social, psychological, and reproductive problems are often associated with menstrual irregularities. Thus, evaluating the factors associated with irregular menstruation is necessary to determine appropriate preventive and treatment strategies and to decrease the associated health problems. The aim of this review was to define normal and irregular menstruation, their types, and prevalence, to recognize the risk factors and causes of irregular menstruation, and to understand their impact on women's health.
C1 [Attia, Ghalia M.] Mansoura Univ, Med Histol & Cell Biol, Mansoura, Egypt.
   [Alharbi, Ohood A.; Aljohani, Reema M.] Taibah Univ, Coll Med, Medina, Saudi Arabia.
C3 Egyptian Knowledge Bank (EKB); Mansoura University; Taibah University
RP Alharbi, OA (corresponding author), Taibah Univ, Coll Med, Medina, Saudi Arabia.
EM ohood.alharbi99@gmail.com
OI Alharbi, Ohood/0009-0009-1567-9734
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NR 76
TC 20
Z9 20
U1 5
U2 20
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
EI 2168-8184
J9 CUREUS J MED SCIENCE
JI Cureus J Med Sci
PD NOV 20
PY 2023
VL 15
IS 11
AR e49146
DI 10.7759/cureus.49146
PG 9
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA Z3AB5
UT WOS:001110823400040
PM 38130524
OA gold, Green Accepted
DA 2025-06-11
ER

PT J
AU Hansel, B
   Bonnefont-Rousselot, D
   Orsoni, A
   Bittar, R
   Giral, P
   Roussel, R
   Marre, M
   Mohammedi, K
   Bruckert, E
   Chapman, MJ
   Kontush, A
AF Hansel, Boris
   Bonnefont-Rousselot, Dominique
   Orsoni, Alexina
   Bittar, Randa
   Giral, Philippe
   Roussel, Ronan
   Marre, Michel
   Mohammedi, Kamel
   Bruckert, Eric
   Chapman, Martin John
   Kontush, Anatol
TI Lifestyle intervention enhances high-density Lipoprotein function among
   patients with metabolic syndrome only at normal low-density lipoprotein
   cholesterol plasma levels
SO JOURNAL OF CLINICAL LIPIDOLOGY
LA English
DT Article
DE Metabolic syndrome; High-density lipoprotein; Antioxidative activity;
   Oxidative stress; Lifestyle intervention
ID ELEVATED OXIDATIVE STRESS; TYPE-2 DIABETES-MELLITUS;
   CORONARY-HEART-DISEASE; APOLIPOPROTEIN-A-I; ANTIOXIDATIVE ACTIVITY;
   PARTICLE-SIZE; CARDIOVASCULAR-DISEASE; MULTICENTER EVALUATION;
   PRIMARY-PREVENTION; OBESE-PATIENTS
AB BACKGROUND: Metabolic syndrome (MetS) is associated with altered lipoprotein metabolism and impairment in the functionality of small, dense high-density lipoprotein (HDL) particles secondary to compositional alterations.
   OBJECTIVE: The objective of this study was to investigate the capacity of a lifestyle program to improve the composition and antioxidative function (AOX) of small dense HDL3c in MetS.
   METHODS: Patients with MetS (n = 33) not taking lipid-lowering drugs were recruited to follow a 12-week educational program to reduce caloric intake and to increase physical activity. HDL subfractions were preparatively isolated by isopycnic density-gradient ultracentrifugation. AOX of HDL3c was assessed as its capacity to inhibit low-density lipoprotein oxidation induced by an azoinitiator.
   RESULTS: AOX of HDL3c was significantly improved (mean reduction in the propagation rate of low-density lipoprotein oxidation by HDL3c, 6.8%, P =.03) and systemic oxidative stress, assessed as plasma levels of 8-isoprostanes, tended to decrease in normocholesterolemic MetS patients (low density lipoprotein cholesterol [LDL-C] < 130 mg/dL) but not in patients with elevated LDL-C levels and in the whole study population. In both the whole study population and the normocholesterolemic subgroup, lifestyle intervention resulted in a significant degree of normalization of HDL3c composition, (enrichment in apolipoprotein A-I and cholesteryl esters, depletion in triglycerides), which was more pronounced at LDL-C < 130 mg/dL.
   CONCLUSION: In patients with MetS, a lifestyle program improves AOX of small, dense HDL in subjects with normal LDL-C levels. Correction of HDL composition, involving partial normalization of apoA-I content and core lipid composition, 2 central features of the lipid hydroperoxide-inactivating capacity of HDL, may account for this effect. (C) 2016 National Lipid Association. All rights reserved.
C1 [Hansel, Boris; Roussel, Ronan; Marre, Michel; Mohammedi, Kamel] Hop Bichat Claude Bernard, Assistance Publ Hop Paris, DHU FIRE, Dept Endocrinol Diabetol & Nutr, Paris, France.
   [Hansel, Boris; Roussel, Ronan; Marre, Michel; Mohammedi, Kamel] Ctr Rech Cordeliers, INSERM, U1138, Paris, France.
   [Hansel, Boris; Roussel, Ronan; Marre, Michel] Univ Paris 07, Paris, France.
   [Bonnefont-Rousselot, Dominique; Bittar, Randa] Grp Hosp Pitie Salpetriere Charles Foix, AP HP, Serv Biochim Metab, Paris, France.
   [Bonnefont-Rousselot, Dominique; Orsoni, Alexina; Bittar, Randa; Chapman, Martin John; Kontush, Anatol] Univ Paris 06, Hop Pitie, INSERM UMRS ICAN 1166, Paris, France.
   [Bonnefont-Rousselot, Dominique] Univ Paris 05, Fac Pharm, Paris, France.
   [Giral, Philippe; Bruckert, Eric] Hop Pitie, AP HP, Serv Endocrinol Metab, Paris, France.
C3 Universite Paris Cite; Assistance Publique Hopitaux Paris (APHP);
   Hopital Universitaire Bichat-Claude Bernard - APHP; Hopital
   Universitaire Saint-Louis - APHP; Sorbonne Universite; Universite Paris
   Cite; Institut National de la Sante et de la Recherche Medicale
   (Inserm); Universite Paris Cite; Assistance Publique Hopitaux Paris
   (APHP); Hopital Universitaire Charles-Foix - APHP; Sorbonne Universite;
   Hopital Universitaire Pitie-Salpetriere - APHP; Assistance Publique
   Hopitaux Paris (APHP); Hopital Universitaire Pitie-Salpetriere - APHP;
   Institut National de la Sante et de la Recherche Medicale (Inserm);
   Sorbonne Universite; Universite Paris Cite; Sorbonne Universite;
   Assistance Publique Hopitaux Paris (APHP); Hopital Universitaire
   Pitie-Salpetriere - APHP
RP Hansel, B (corresponding author), Hop Bichat Claude Bernard, Serv Endocrinol Metab, 46 Rue Henri Huchard, F-75018 Paris, France.
EM boris.hansel@aphp.fr
RI Mohammedi, Kamel/AAG-3129-2019; Rousselot, Bonnefont/U-7434-2019;
   chapman, john/Y-2742-2019; Greiver, Michelle/N-8764-2015; Kontush,
   Anatol/J-2198-2016; ORSONI, Alexina/C-6740-2009
OI ORSONI, Alexina/0000-0003-4250-6280; Mohammedi,
   Kamel/0000-0001-6139-1197; Bonnefont-Rousselot,
   Dominique/0000-0003-4689-9202; Kontush, Anatol/0000-0002-9008-7335
FU National Institute of Health and Medical Research; University of Pierre
   and Mary Curie (UPMC); Fondation de France; Agence Nationale de la
   Recherche (ANR); Fondation pour la Recherche Medicale
FX This study was supported by the National Institute of Health and Medical
   Research, University of Pierre and Mary Curie (UPMC), the Fondation de
   France, the Agence Nationale de la Recherche (ANR), and the Fondation
   pour la Recherche Medicale. We are indebted to all subjects and nursing
   staff involved in the study.
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NR 35
TC 10
Z9 14
U1 0
U2 16
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1933-2874
EI 1876-4789
J9 J CLIN LIPIDOL
JI J. Clin. Lipidol.
PD OCT
PY 2016
VL 10
IS 5
BP 1172
EP 1181
DI 10.1016/j.jacl.2016.05.008
PG 10
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA DZ5LN
UT WOS:000385903700015
PM 27678434
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Institoris, A
   Lenti, L
   Domoki, F
   Wappler, E
   Gáspár, T
   Katakam, PV
   Bari, F
   Busija, DW
AF Institoris, Adam
   Lenti, Laura
   Domoki, Ferenc
   Wappler, Edina
   Gaspar, Tamas
   Katakam, Prasad V.
   Bari, Ferenc
   Busija, David W.
TI Cerebral Microcirculatory Responses of Insulin-Resistant Rats are
   Preserved to Physiological and Pharmacological Stimuli
SO MICROCIRCULATION
LA English
DT Article
DE Zucker obese; cortical spreading depression; N-methyl-d-aspartate;
   bicuculline; hypercapnia
ID METHYL-D-ASPARTATE; CORTICAL SPREADING DEPRESSION; NITRIC-OXIDE
   SYNTHASE; ZUCKER OBESE RATS; PIAL ARTERIOLAR DILATION; METABOLIC
   SYNDROME; BLOOD-FLOW; K-ATP; INDUCED VASODILATION; EPILEPTIFORM EVENTS
AB Objective Previously, we have shown that IR impairs the vascular reactivity of the major cerebral arteries of ZO rats prior to the occurrence of Type-II diabetes mellitus. However, the functional state of the microcirculation in the cerebral cortex is still being explored.
   Methods We tested the local CoBF responses of 11-13-week-old ZO (n = 31) and control ZL (n = 32) rats to several stimuli measured by LDF using a closed cranial window setup.
   Results The topical application of 1-100 mu m bradykinin elicited the same degree of CoBF elevation in both ZL and ZO groups. There was no significant difference in the incidence, latency, and amplitude of the NMDA-induced CSD-related hyperemia between the ZO and ZL groups. Hypercapnic CoBF response to 5% carbon-dioxide ventilation did not significantly change in the ZO compared with the ZL. Topical bicuculline-induced cortical seizure was accompanied by the same increase of CoBF in both the ZO and ZL at all bicuculline doses.
   Conclusions CoBF responses of the microcirculation are preserved in the early period of the metabolic syndrome, which creates an opportunity for intervention to prevent and restore the function of the major cerebral vascular beds.
C1 [Institoris, Adam] Univ Szeged, Dept Physiol, Fac Med, Sch Med, H-6720 Szeged, Hungary.
   [Institoris, Adam; Lenti, Laura; Katakam, Prasad V.; Busija, David W.] Wake Forest Univ Hlth Sci, Dept Physiol & Pharmacol, Winston Salem, NC USA.
   [Wappler, Edina; Katakam, Prasad V.; Busija, David W.] Tulane Univ, Sch Med, Dept Pharmacol, New Orleans, LA 70112 USA.
   [Bari, Ferenc] Univ Szeged, Dept Med Informat & Med Phys, Sch Med, H-6720 Szeged, Hungary.
C3 Szeged University; Wake Forest University; Wake Forest University School
   of Medicine; Tulane University; Szeged University
RP Institoris, A (corresponding author), Univ Szeged, Dept Physiol, Fac Med, Sch Med, Dom Ter 10, H-6720 Szeged, Hungary.
EM instiadam@gmail.com
RI K, P/AAL-6310-2021; Domoki, Ferenc/K-5336-2012
OI Wappler-Guzzetta, Edina/0000-0002-2195-5960; Katakam,
   Prasad/0000-0002-4708-9140
FU National Heart, Lung, and Blood Institute [HL-030260, HL-065380,
   HL-077731, HL-093554]; Hungarian Scientific Research Fund [OTKA K81266,
   TAMOP-4.2.1./B-09/1/konv-2010-0005]; Janos Bolyai Research Scholarship
   of the Hungarian Academy of Sciences
FX We thank Nancy Busija for editing the manuscript. This work was
   supported by National Heart, Lung, and Blood Institute Grants HL-030260,
   HL-065380, HL-077731, and HL-093554, Hungarian Scientific Research Fund
   Grant OTKA K81266, and TAMOP-4.2.1./B-09/1/konv-2010-0005. Ferenc Domoki
   was supported by the Janos Bolyai Research Scholarship of the Hungarian
   Academy of Sciences.
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NR 61
TC 8
Z9 9
U1 0
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1073-9688
EI 1549-8719
J9 MICROCIRCULATION
JI Microcirculation
PD NOV
PY 2012
VL 19
IS 8
BP 749
EP 756
DI 10.1111/j.1549-8719.2012.00213.x
PG 8
WC Hematology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Hematology; Cardiovascular System & Cardiology
GA 041CI
UT WOS:000311373400009
PM 22845548
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Lucini, D
   Zanuso, S
   Blair, S
   Pagani, M
AF Lucini, Daniela
   Zanuso, Silvano
   Blair, Steven
   Pagani, Massimo
TI A simple healthy lifestyle index as a proxy of wellness: a proof of
   concept
SO ACTA DIABETOLOGICA
LA English
DT Article
DE Clinical prevention; Cardiovascular health; Diet; Stress; Exercise
ID PHYSICAL-ACTIVITY; CARDIOVASCULAR-DISEASE; SCIENTIFIC STATEMENT;
   METABOLIC SYNDROME; RISK-FACTORS; PUBLIC-HEALTH; PRIMARY-CARE; STRESS;
   PREVENTION; IMPACT
AB The evidence supporting the importance of a healthy lifestyle (active life, healthy diet, not smoking, and low stress) as a part of programs for primary and secondary prevention of cardiometabolic diseases is strong, compelling, and continuously growing. In this study, we test whether a simple web-based healthy lifestyle index, using self-reports, is related to indices of cardiovascular health and metabolic syndrome and could be employed in large wellness programs intended to promote healthy lifestyle. We studied 411 workers in an Italian multinational factory who were enrolled in a voluntary program consisting of a health checkup and an online questionnaire on lifestyle. These domains were combined into a single simple index. Participants were subdivided into three healthy lifestyle index (HI) groups (red, yellow, and green) ranging from poor to good HI quality (HI from red to green: 41.8 +/- A 14.6; 75.7 +/- A 8.5; 93.8 +/- A 2.2; p < 0.05). The groups differed in indicators of cardiovascular and metabolic health (waist circumference females: 82.1 +/- A 9.56, 78.9 +/- A 9.3, 72.7 +/- A 6.6; males: 95.2 +/- A 11.7, 90.0 +/- A 9.5, 85.7 +/- A 6.1 cm; group difference p < 0.05). Moreover, they differed significantly in the likelihood of having more components of the metabolic syndrome and, conversely, fewer components of the ideal cardiovascular health profile (with red having the worst profile). The red group was also characterized by the highest absenteeism. We report for the first time that a web-based self-reported poor health behavior was significantly associated with clinical and laboratory (partial correlation between HI and high-density cholesterol 0.192; body mass index -0.288; systolic blood pressure -0.130; all p < 0.05) results indicating a negative cardiometabolic profile.
C1 [Lucini, Daniela; Pagani, Massimo] Univ Milan, Ctr Ric Terapia Neurovegetat & Med Esercizio, Milan, Italy.
   [Lucini, Daniela] Humanitas Clin & Res Ctr, UO Med Esercizio & Patol Funz, I-20089 Milan, Italy.
   [Zanuso, Silvano] Univ Greenwich, Chatham, Kent, England.
   [Zanuso, Silvano] Technogym Sci Dept, Cesena, Italy.
   [Blair, Steven] Univ S Carolina, Dept Exercise Sci & Epidemiol & Biostat, Columbia, SC 29208 USA.
C3 University of Milan; University of Greenwich; University of South
   Carolina System; University of South Carolina Columbia
RP Lucini, D (corresponding author), Humanitas Clin & Res Ctr, UO Med Esercizio & Patol Funz, Via Alessandro Manzoni 56, I-20089 Milan, Italy.
EM daniela.lucini@unimi.it
RI Blair, Steven/AFU-2008-2022; Lucini, Daniela/ABD-7517-2021
OI Lucini, Daniela/0000-0003-4845-8988
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NR 43
TC 21
Z9 22
U1 0
U2 18
PU SPRINGER-VERLAG ITALIA SRL
PI MILAN
PA VIA DECEMBRIO, 28, MILAN, 20137, ITALY
SN 0940-5429
EI 1432-5233
J9 ACTA DIABETOL
JI Acta Diabetol.
PD FEB
PY 2015
VL 52
IS 1
BP 81
EP 89
DI 10.1007/s00592-014-0605-z
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA CA9EQ
UT WOS:000349224100010
PM 24915785
DA 2025-06-11
ER

PT J
AU Scheinberg, AR
   Martin, P
   Turkeltaub, JA
AF Scheinberg, Andrew R.
   Martin, Paul
   Turkeltaub, Joshua A.
TI Long-Term Care of the Liver Transplant Recipient
SO CLINICS IN LIVER DISEASE
LA English
DT Article
DE Liver transplant; Complications; Long-term care; Metabolic syndrome;
   Survivorship
ID RISK-FACTORS; HYPERTENSION; MANAGEMENT; OBESITY; CANCER; OUTCOMES;
   DISEASE
AB Decades of advances in surgical techniques and immunosuppression regimens afford the liver transplant recipient increased longevity. Many of the metabolic derangements managed in the liver transplant recipient will require pharmacologic intervention; however, the importance of minimizing immunosuppression, if feasible, combined with a healthy lifestyle cannot be over emphasized. One of the goals of liver transplantation in addition to prolonging survival is to improve the recipient's quality of life (QoL). Assessments of QoL, mood, and screening for mental health issues should be routinely performed. The concept of survivorship, initially adopted in the world of oncology, highlights a more holistic approach to the liver transplant recipient with an emphasis on psychological, social, and spiritual well-being along with the medical management.42 In addition to ongoing efforts to further improve graft survival and improve the longevity of liver transplant recipients, further research exploring transplant survivorship domains will also ensure improved outcomes and overall success.42
C1 [Scheinberg, Andrew R.; Turkeltaub, Joshua A.] Univ Miami, Miller Sch Med, Div Digest Hlth & Liver Dis, 1120 Northwest 14th St, Miami, FL 33136 USA.
   [Martin, Paul] Cedars Sinai Med Ctr, Comprehens Transplant Ctr, Karsh Div Gastroenterol & Hepatol, Clin Hepatol Educ & Res, Los Angeles, CA USA.
C3 University of Miami; Cedars Sinai Medical Center
RP Scheinberg, AR (corresponding author), Univ Miami, Miller Sch Med, Div Digest Hlth & Liver Dis, 1120 Northwest 14th St, Miami, FL 33136 USA.
EM ascheinberg@med.miami.edu
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NR 42
TC 0
Z9 0
U1 0
U2 0
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 1089-3261
EI 1557-8224
J9 CLIN LIVER DIS
JI Clin. Liver Dis.
PD MAY
PY 2025
VL 29
IS 2
BP 303
EP 312
DI 10.1016/j.cld.2024.12.007
PG 10
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 2ES2E
UT WOS:001480881300001
PM 40287273
DA 2025-06-11
ER

PT J
AU Moniruzzaman, M
   Reid, LA
   Jones, KK
   Zenk, SN
   Vega, GL
   Grundy, SM
   Sims, M
   Powell-Wiley, TM
   Tamura, K
AF Moniruzzaman, Mohammad
   Reid, Lauren A.
   Jones, Kelly K.
   Zenk, Shannon N.
   Vega, Gloria L.
   Grundy, Scott M.
   Sims, Mario
   Powell-Wiley, Tiffany M.
   Tamura, Kosuke
TI Multilevel Mediators on the Associations of Neighborhood Social
   Environmental Factors and Severity of Metabolic Syndrome: The Jackson
   Heart Study
SO JOURNAL OF THE AMERICAN HEART ASSOCIATION
LA English
DT Article
DE C-reactive protein; mediation analysis; metabolic syndrome;
   neighborhood; physical activity
ID C-REACTIVE PROTEIN; AFRICAN-AMERICANS; PHYSICAL-ACTIVITY; PSYCHOSOCIAL
   STRESSORS; CARDIOVASCULAR HEALTH; RISK; DISPARITIES; COMMUNITIES;
   MANAGEMENT; SEX
AB Background Neighborhood characteristics serve as risk factors for metabolic syndrome (MetS). However, the intermediary factors linking this relationship remain understudied. Thus, we investigated the sex-specific mediating role of C-reactive protein, physical activity (PA), and perceived stress in the associations of perceived neighborhood social environment (PNSE) with MetS severity among Black adults.Methods and Results This cross-sectional study included 3185 adults (64% women) from exam 1 (2000-2004) of the Jackson Heart Study. MetS severity Z scores were calculated based on the Adult Treatment Panel III criteria formula. PNSE included neighborhood violence, problems, and social cohesion. Men and women were analyzed separately. A bootstrap resampling technique with 95% bias-corrected CI (95% BC CI) was used to evaluate whether C-reactive protein, PA, and perceived stress mediated the association between each PNSE and MetS severity, adjusting for covariates. All PNSE factors were directly related to MetS severity in women but not in men. In women, neighborhood problems were indirectly associated with MetS severity mediated through PA (beta=0.02 [95% BC CI, 0.00-0.05]). In men, neighborhood violence, problems, and social cohesion were indirectly associated with MetS severity mediated through PA (beta=0.05 [95% BC CI, 0.01-0.10]; beta=0.03 [95% BC CI, 0.00-0.06]; and beta=-0.04 [95% BC CI, -0.09 to -0.01], respectively). Neither C-reactive protein nor perceived stress mediated such associations in either women or men.Conclusions All PNSEs (violence, problems, and social cohesion) were directly related to MetS severity in women only. PA mediated the relationship between each PNSE and MetS in a sex-specific manner. Efforts focusing on local conditions are needed to better understand why such disparities exist for at-risk minoritized groups.
C1 [Moniruzzaman, Mohammad; Tamura, Kosuke] Natl Inst Minor Hlth & Hlth Dispar, Populat & Community Hlth Sci Branch, Div Intramural Res, Sociospatial Determinants Hlth SSDH Lab,NIH, Bldg 3,3 Ctr Dr, Bethesda, MD 20892 USA.
   [Reid, Lauren A.] South Coll, Sch Phys Assistant Studies, Atlanta, GA USA.
   [Reid, Lauren A.; Jones, Kelly K.; Zenk, Shannon N.] Natl Inst Minor Hlth & Hlth Dispar, Neighborhoods & Hlth Lab, Populat & Community Hlth Sci Branch, Div Intramural Res,NIH, Bethesda, MD USA.
   [Zenk, Shannon N.] Natl Inst Nursing Res, NIH, Bethesda, MD USA.
   [Vega, Gloria L.; Grundy, Scott M.] Univ Texas Southwestern Med Ctr Dallas, Ctr Human Nutr, Dallas, TX USA.
   [Sims, Mario] Univ Calif Riverside, Sch Med, Dept Social Med Populat & Publ Hlth, Riverside, CA USA.
   [Powell-Wiley, Tiffany M.] NHLBI, Social Determinants Obes & Cardiovasc Risk Lab, Cardiovasc Branch, Div Intramural Res, Bethesda, MD USA.
   [Powell-Wiley, Tiffany M.] Natl Inst Minor Hlth & Hlth Dispar, Div Intramural Res, NIH, Bethesda, MD USA.
C3 National Institutes of Health (NIH) - USA; NIH National Institute on
   Minority Health & Health Disparities (NIMHD); Division of Intramural
   Research (DIR); National Institutes of Health (NIH) - USA; NIH National
   Institute on Minority Health & Health Disparities (NIMHD); Division of
   Intramural Research (DIR); National Institutes of Health (NIH) - USA;
   NIH National Institute of Nursing Research (NINR); University of Texas
   System; University of Texas Southwestern Medical Center Dallas;
   University of California System; University of California Riverside;
   National Institutes of Health (NIH) - USA; NIH National Heart Lung &
   Blood Institute (NHLBI); National Institutes of Health (NIH) - USA;
   Division of Intramural Research (DIR); NIH National Institute on
   Minority Health & Health Disparities (NIMHD)
RP Tamura, K (corresponding author), Natl Inst Minor Hlth & Hlth Dispar, Populat & Community Hlth Sci Branch, Div Intramural Res, Sociospatial Determinants Hlth SSDH Lab,NIH, Bldg 3,3 Ctr Dr, Bethesda, MD 20892 USA.
EM kosuke.tamura@nih.gov
RI PowellWiley, Tiffany/MCY-2981-2025; Zennk, Shannon/D-4096-2018; Tamura,
   Kosuke/S-9498-2019; Mohammad, Moniruzzaman/H-8503-2019
OI Tamura, Kosuke/0000-0002-4920-2856; Jones, Kelly/0000-0002-1552-7847;
   Reid, Lauren/0000-0003-1021-8364; Mohammad,
   Moniruzzaman/0000-0003-2144-7111; Powell-Wiley, Tiffany
   M./0000-0001-9488-4131
FU Health Laboratory at the National Institute on Minority Health and
   Health Disparities (NIMHD); National Institutes of Health (NIH)
FX The authors thank the staff and participants of the JHS. Dr Reid had
   worked on this study while she was a postdoctoral fellow at the
   Neighborhoods and Health Laboratory at the National Institute on
   Minority Health and Health Disparities (NIMHD) and the National
   Institutes of Health (NIH).
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NR 56
TC 1
Z9 1
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
EI 2047-9980
J9 J AM HEART ASSOC
JI J. Am. Heart Assoc.
PD JAN 7
PY 2025
VL 14
IS 1
AR e035216
DI 10.1161/JAHA.124.035216
PG 10
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA R3P3W
UT WOS:001390605800001
PM 39704229
DA 2025-06-11
ER

PT J
AU Yubero-Serrano, EM
   Delgado-Lista, J
   Peña-Orihuela, P
   Perez-Martinez, P
   Fuentes, F
   Marin, C
   Tunez, I
   Tinahones, FJ
   Perez-Jimenez, F
   Roche, HM
   Lopez-Miranda, J
AF Maria Yubero-Serrano, Elena
   Delgado-Lista, Javier
   Pena-Orihuela, Patricia
   Perez-Martinez, Pablo
   Fuentes, Francisco
   Marin, Carmen
   Tunez, Isaac
   Jose Tinahones, Francisco
   Perez-Jimenez, Francisco
   Roche, Helen M.
   Lopez-Miranda, Jose
TI Oxidative stress is associated with the number of components of
   metabolic syndrome: LIPGENE study
SO EXPERIMENTAL AND MOLECULAR MEDICINE
LA English
DT Article
DE cardiovascular risk factors; endothelial dysfunction; LIPGENE study;
   metabolic syndrome; oxidative stress; redox state
ID INSULIN-RESISTANCE; RISK-FACTORS; CARDIOVASCULAR-DISEASE; ENDOTHELIAL
   FUNCTION; ANTIOXIDANT ENZYMES; INFLAMMATION; SENSITIVITY; OBESITY;
   IMPACT; CELLS
AB Previous evidence supports the important role that oxidative stress (OxS) plays in metabolic syndrome (MetS)-related manifestations. We determined the relationship between the number of MetS components and the degree of OxS in MetS patients. In this comparative cross-sectional study from the LIPGENE cohort, a total of 91 MetS patients (43 men and 48 women; aged between 45 and 68 years) were divided into four groups based on the number of MetS components: subjects with 2, 3, 4 and 5 MetS components (n = 20, 31, 28 and 12, respectively). We measured ischemic reactive hyperemia (IRH), plasma levels of soluble vascular cell adhesion molecule-1 (sVCAM-1), total nitrite, lipid peroxidation products (LPO), hydrogen peroxide (H2O2), superoxide dismutase ( SOD) and glutathione peroxidase (GPx) plasma activities. sVCAM-1, H2O2 and LPO levels were lower in subjects with 2 or 3 MetS components than subjects with 4 or 5 MetS components. IRH and total nitrite levels were higher in subjects with 2 or 3 MetS components than subjects with 4 or 5 MetS components. SOD and GPx activities were lower in subjects with 2 MetS components than subjects with 4 or 5 MetS components. Waist circumference, weight, age, homeostatic model assessment-beta, triglycerides (TGs), high-density lipoprotein and sVCAM-1 levels were significantly correlated with SOD activity. MetS subjects with more MetS components may have a higher OxS level. Furthermore, association between SOD activity and MetS components may indicate that this variable could be the most relevant OxS biomarker in patients suffering from MetS and could be used as a predictive tool to determine the degree of the underlying OxS in MetS.
C1 [Maria Yubero-Serrano, Elena; Delgado-Lista, Javier; Pena-Orihuela, Patricia; Perez-Martinez, Pablo; Fuentes, Francisco; Marin, Carmen; Perez-Jimenez, Francisco; Lopez-Miranda, Jose] Univ Cordoba, Reina Sofia Univ Hosp, IMIBIC, Lipids & Atherosclerosis Unit, E-14004 Cordoba, Spain.
   [Maria Yubero-Serrano, Elena; Delgado-Lista, Javier; Pena-Orihuela, Patricia; Perez-Martinez, Pablo; Fuentes, Francisco; Marin, Carmen; Jose Tinahones, Francisco; Perez-Jimenez, Francisco; Lopez-Miranda, Jose] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr CIBEROBN, Madrid, Spain.
   [Tunez, Isaac] Univ Cordoba, Fac Med, Dept Biochem & Mol Biol IMIBIC, E-14004 Cordoba, Spain.
   [Jose Tinahones, Francisco] Hosp Virgen de la Victoria, Dept Endocrinol, Biomed Res Lab, Malaga, Spain.
   [Roche, Helen M.] Univ Coll Dublin, UCD Conway Inst, Sch Publ Hlth & Populat Sci, Nutrigen Res Grp, Dublin 2, Ireland.
C3 Universidad de Cordoba; Hospital Universitario Reina Sofia - Cordoba;
   CIBER - Centro de Investigacion Biomedica en Red; CIBEROBN; Instituto de
   Salud Carlos III; Universidad de Cordoba; University College Dublin
RP Lopez-Miranda, J (corresponding author), Univ Cordoba, Reina Sofia Univ Hosp, IMIBIC, Lipids & Atherosclerosis Unit, Avda Menendez Pidal S-N, E-14004 Cordoba, Spain.
EM jlopezmir@uco.es
RI Roche, Helen/AAF-4164-2019; Fuentes-Jimenez, Francisco
   Jose/HTM-0138-2023; Yubero-Serrano, Elena/H-4832-2013; Marin Hinojosa,
   Carmen/AFO-1294-2022; Delgado-Lista, Javier/KAM-7412-2024; Jimenez,
   Francisco/AAJ-9559-2021; Lopez-Miranda, Jose/Y-8306-2019; Tinahones,
   Francisco/AAB-2882-2020; FUENTES JIMENEZ, FRANCISCO/G-4311-2016; Perez
   Martinez, Pablo/AEL-6176-2022
OI Pena Orihuela, Patricia J/0009-0009-9970-043X; Lopez-Miranda,
   Jose/0000-0002-8844-0718; Delgado Lista, Francisco
   Javier/0000-0002-2982-2716; FUENTES JIMENEZ,
   FRANCISCO/0000-0002-4584-7366; Yubero-Serrano, Elena
   M/0000-0002-2733-5359; Roche, Helen/0000-0002-0628-3318; Tinahones,
   Francisco J/0000-0001-6871-4403; Perez Martinez,
   Pablo/0000-0001-7716-8117; Perez Jimenez, Francisco/0000-0001-9808-1280;
   Perez-Jimenez, Francisco/0000-0001-7499-7681
FU Ministerio de Ciencia e Innovacion [AGL2006-01979, AGL2009-12270]; CIBER
   Fisiopatologia de la Obesidad y Nutrition [CB06/03/0047]; Consejeria de
   Innovacion, Ciencia y Empresa, Junta de Andalucia [P06-CTS-01425,
   CVI-7450]; Consejeria de Salud, Junta de Andalucia [06/128, 07/43,
   PI0193/2009, 06/129]
FX This research was supported partly by grants from the Ministerio de
   Ciencia e Innovacion (AGL2006-01979, AGL2009-12270 to JL-M),
   ('CB06/03/0047-CIBER Fisiopatologia de la Obesidad y Nutrition' is an
   ISCIII grant awarded to FP-J), Consejeria de Innovacion, Ciencia y
   Empresa, Junta de Andalucia (P06-CTS-01425 and CVI-7450 to JL-M);
   Consejeria de Salud, Junta de Andalucia (06/128, 07/43, PI0193/2009 to
   JL-M, 06/129 to FP-J).
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NR 41
TC 78
Z9 86
U1 0
U2 12
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 1226-3613
EI 2092-6413
J9 EXP MOL MED
JI Exp. Mol. Med.
PD JUN
PY 2013
VL 45
AR e28
DI 10.1038/emm.2013.53
PG 7
WC Biochemistry & Molecular Biology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Research & Experimental Medicine
GA 174VT
UT WOS:000321185500003
PM 23788131
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Chaldakov, GN
   Tonchev, AB
   Aloe, L
AF Chaldakov, George N.
   Tonchev, Anton B.
   Aloe, Luigi
TI NGF and BDNF: from nerves to adipose tissue, from neurokines to
   metabokines
SO RIVISTA DI PSICHIATRIA
LA English
DT Review
DE adipokines; neurotrophins; synaptotrophic effects; metabotrophic
   effects; ampakines; deacetylase; calorie restriction
ID NEUROTROPHIC FACTOR BDNF; ADIPOKINE GENE-EXPRESSION; TYPE-2
   DIABETES-MELLITUS; GROWTH-FACTOR NGF; ALZHEIMERS-DISEASE; METABOLIC
   SYNDROME; PSYCHIATRIC-DISORDERS; NEURONAL PLASTICITY; TOPICAL
   APPLICATION; GLUCOSE-METABOLISM
AB Neurotrophins, particularly, NGF and BDNF are now well recognized to mediate a dizzying number of trophobiological effects, ranging from the Rita Levi-Montalcini's neurotrophic through immunotrophic to metabotrophic effects. These are implicated in the pathogenesis of various diseases including neuropsychiatric and cardiometabolic diseases, such as dementia, depression, type 2 diabetes and obesity that may express a common phenotype and coexistence. Recently, adipobiology (adiposcience) as become a focus of numerous studies showing that the adipose tissue is the body's largest endocrine organ producing multiple signaling proteins, including NGF and BDNF, all these dubbed adipokines. On the basis of our and other authors' evidence that low NGF and/or BDNF levels are found in cardiometabolic diseases (atherosclerosis, obesity, type 2 diabetes, metabolic syndrome), a hypothesis of a critical role of neuro-metabotrophic deficit in the pathogenesis of these diseases has been raised. Since NGF and BDNF also exerts various synaptotrophic effects involved in cognitive enhancement, this hypothesis might also be related to neuropsychiatric diseases such as dementia, depression, schizophrenia, autism, Rett syndrome, anorexia nervosa, and bulimia nervosa. Finally, NGF- and BDNF-based therapeutic approach, including ampakines, antidepressants, selective deacetylase inhibitors, statins, peroxisome proliferator-activated receptor gamma agonists, and "brain food" and calorie restriction, is outlined.
C1 [Chaldakov, George N.; Tonchev, Anton B.] Med Univ, Div Cell Biol, Varna, Bulgaria.
   [Aloe, Luigi] European Brain Res Inst, Natl Res Council, Inst Neurobiol & Mol Med, Rome, Italy.
C3 Medical University Varna
RP Chaldakov, GN (corresponding author), Med Univ, Div Cell Biol, Varna, Bulgaria.
EM chaldakov@yahoo.com
RI Tonchev, Anton/LKK-5568-2024
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NR 161
TC 81
Z9 91
U1 0
U2 14
PU PENSIERO SCIENTIFICO EDITOR
PI ROME
PA VIA BRADANO 3/C, 00199 ROME, ITALY
SN 0035-6484
EI 2038-2502
J9 RIV PSICHIATR
JI Riv. Psichiatr.
PD MAR-APR
PY 2009
VL 44
IS 2
BP 79
EP 87
PG 9
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 439UT
UT WOS:000265653500002
PM 20066808
DA 2025-06-11
ER

PT J
AU Wärdig, RE
   Bachrach-Lindström, M
   Foldemo, A
   Lindström, T
   Hultsjö, S
AF Wardig, Rikard Erik
   Bachrach-Lindstrom, Margareta
   Foldemo, Anniqa
   Lindstrom, Torbjorn
   Hultsjo, Sally
TI Prerequisites for A Healthy Lifestyle-Experiences of Persons with
   Psychosis
SO ISSUES IN MENTAL HEALTH NURSING
LA English
DT Article
ID PHYSICAL HEALTH; MENTAL-ILLNESS; METABOLIC SYNDROME; SCHIZOPHRENIA;
   WEIGHT; CARE; SATISFACTION; OUTPATIENTS; EXERCISE; PEOPLE
AB The purpose of this study is to explore prerequisites for a healthy lifestyle as described by individuals diagnosed with psychosis. Forty participants who had performed a lifestyle intervention focusing on physical activities and lifestyle education were interviewed. Conventional content analysis was used. The results are described in two categories: (1) Individual Prerequisites and (2) Being a Part of Society. The individuals said that they got stuck in a state of planning without taking action. It was pointless to make a bigger effort because the psychotic disorder could, at any time, worsen the prerequisites. They also said that they wanted to live like everybody else and therefore tried to adopt a normal lifestyle. Future interventions or professional support by mental health nurses and other health care givers should target the transition from planning to action to achieve a healthy lifestyle, and should help the individual to taking part in society.
C1 [Wardig, Rikard Erik; Bachrach-Lindstrom, Margareta; Foldemo, Anniqa; Lindstrom, Torbjorn] Linkoping Univ, Linkoping, Sweden.
   [Hultsjo, Sally] Ryhov Cty Hosp, Psychiat Clin, Jonkoping, Sweden.
C3 Linkoping University
RP Wärdig, RE (corresponding author), Linkoping Univ, Dept Med & Hlth Sci, Linkoping, Sweden.
EM rikard.wardig@liu.se
OI Foldemo, Anniqa/0000-0003-4311-0739
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NR 51
TC 17
Z9 18
U1 0
U2 4
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 0161-2840
EI 1096-4673
J9 ISSUES MENT HEALTH N
JI Issues Ment. Health Nurs.
PD AUG
PY 2013
VL 34
IS 8
BP 602
EP 610
DI 10.3109/01612840.2013.790525
PG 9
WC Nursing; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Psychiatry
GA V38TV
UT WOS:000209366600006
PM 23909672
DA 2025-06-11
ER

PT J
AU Prakash, P
   Khanna, V
   Singh, V
   Jyoti, A
   Jain, M
   Keshari, RS
   Barthwal, MK
   Dikshit, M
AF Prakash, Prem
   Khanna, Vivek
   Singh, Vishal
   Jyoti, Anupam
   Jain, Manish
   Keshari, Ravi Shankar
   Barthwal, Manoj Kumar
   Dikshit, Madhu
TI Atorvastatin Protects against Ischemia-Reperfusion Injury in
   Fructose-Induced Insulin Resistant Rats
SO CARDIOVASCULAR DRUGS AND THERAPY
LA English
DT Article
DE High fructose diet; Insulin Resistance Syndrome; Endothelial
   Dysfunction; Myocardial Ischemia-Reperfusion Injury; Atorvastatin;
   Akt/Nitric Oxide Synthase (NOS)
ID NITRIC-OXIDE SYNTHASE; PRIOR MYOCARDIAL-INFARCTION; AORTIC
   ENDOTHELIAL-CELLS; CORONARY-HEART-DISEASE; ISCHEMIA/REPERFUSION INJURY;
   CARDIOVASCULAR-DISEASES; REDUCTASE INHIBITORS; MEDIATED RELAXATION;
   ANOXIC TISSUES; EXPRESSION
AB High fructose (HFr) intake is known to cause insulin resistance syndrome (IRS), however its effect against acute coronary events remains elusive. The present study was undertaken to evaluate the effect of HFr (60%) diet on myocardial ischemia-reperfusion (MI-RP) injury and its modulation by atorvastatin treatment.
   Wistar rats kept on HFr/chow feeding for 10 weeks, received atorvastatin (30 mg/kg, per oral) or vehicle for two additional weeks followed by MI-RP injury.
   MI-RP injury was significantly augmented in HFr fed rats, as evident by the increase in infarct size (IS, 65 +/- 5% vs. 43 +/- 7%) and activities of cardiac injury biomarkers [serum lactate dehydrogenase (LDH, 698 +/- 57 vs. 444 +/- 26 U/L), creatinine kinase (CK-MB, 584 +/- 58 vs. 435 +/- 28 U/L) and tissue myeloperoxidase (MPO, 235 +/- 15 vs. 101 +/- 11 mu M/min/100 mg tissue)]. Insulin resistance (plasma glucose, 64 +/- 5 vs. 100 +/- 5 mg/dl; AUC (0-120 min), p < 0.05), MI-RP injury (IS 20 +/- 5%, LDH 292 +/- 28 U/L, CK-MB 257 +/- 13 U/L, MPO 95 +/- 5 mu M/min/100 mg tissue) and triglyceride (TG) level were significantly reduced, while myocardial Akt, p-Akt, eNOS, p-eNOS and iNOS protein expression were significantly enhanced following atorvastatin treatment in comparison to HFr fed rats. Oxidative stress marker, malondialdehyde and circulating levels of inflammatory cytokines (CRP, IL-6, IFN-gamma and TNF) were significantly reduced, while total nitrite content in the tissue and plasma was significantly augmented in atorvastatin treated rats. Atorvastatin also ameliorated endothelial dysfunction and significantly enhanced aortic Akt and eNOS protein expression.
   Atorvastatin conferred significant protection against MI-RP injury and alleviated HFr induced IRS possibly by increasing NOS expression through Akt dependent pathway.
C1 [Prakash, Prem; Khanna, Vivek; Singh, Vishal; Jyoti, Anupam; Jain, Manish; Keshari, Ravi Shankar; Barthwal, Manoj Kumar; Dikshit, Madhu] CSIR Cent Drug Res Inst, Div Pharmacol, Lucknow 226001, Uttar Pradesh, India.
C3 Council of Scientific & Industrial Research (CSIR) - India; CSIR -
   Central Drug Research Institute (CDRI)
RP Dikshit, M (corresponding author), CSIR Cent Drug Res Inst, Div Pharmacol, 1 MG Marg, Lucknow 226001, Uttar Pradesh, India.
EM madhu_dikshit@cdri.res.in
RI Singh, Vishal/N-1838-2019; Prakash, Prem/AAI-1672-2020; Jain,
   Manish/ABE-7652-2021
OI Jyoti, Anupam/0000-0002-4135-7466; Jain, Manish/0000-0002-7263-9829;
   Khanna, Vivek/0000-0003-0541-5355; Prakash, Prem/0000-0001-9501-0065;
   Singh, Vishal/0000-0003-3577-1713
FU Central Drug Research Institute (CDRI); Council of Scientific and
   Industrial Research (CSIR), Government of India [NWP0034]; DBT-INDIGO
   project; Council of Scientific and Industrial Research (CSIR); Indian
   Council of Medical Research (ICMR), India
FX This work was supported by Central Drug Research Institute (CDRI),
   Council of Scientific and Industrial Research (CSIR), Government of
   India [NWP0034] and DBT-INDIGO project. We gratefully acknowledge the
   award of research fellowships by the Council of Scientific and
   Industrial Research (CSIR) and Indian Council of Medical Research
   (ICMR), India.
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NR 64
TC 23
Z9 27
U1 0
U2 4
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0920-3206
J9 CARDIOVASC DRUG THER
JI Cardiovasc. Drugs Ther.
PD AUG
PY 2011
VL 25
IS 4
BP 285
EP 297
DI 10.1007/s10557-011-6312-x
PG 13
WC Cardiac & Cardiovascular Systems; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Pharmacology & Pharmacy
GA 804DN
UT WOS:000293634500003
PM 21671014
DA 2025-06-11
ER

PT J
AU Mastrocola, R
   Aragno, M
   Alloatti, G
   Collino, M
   Penna, C
   Pagliaro, P
AF Mastrocola, Raffaella
   Aragno, Manuela
   Alloatti, Giuseppe
   Collino, Massimo
   Penna, Claudia
   Pagliaro, Pasquale
TI Metaflammation: Tissue-Specific Alterations of the NLRP3 Inflammasome
   Platform in Metabolic Syndrome
SO CURRENT MEDICINAL CHEMISTRY
LA English
DT Review
DE Metabolic syndrome; metaflammation; NLRP3 inflammasome; oxidative
   stress; aging; myocardial ischemia/reperfusion; steatohepatitis; chronic
   kidney disease
ID NONALCOHOLIC FATTY LIVER; GLYCATION END-PRODUCTS;
   MYOCARDIAL-ISCHEMIA-REPERFUSION; RECEPTOR PROTEIN-3 INFLAMMASOME;
   THIOREDOXIN-INTERACTING PROTEIN; CHRONIC KIDNEY-DISEASE; DIET-INDUCED
   OBESITY; NF-KAPPA-B; INSULIN-RESISTANCE; DIABETIC-NEPHROPATHY
AB In the last decades, the extension of life expectancy and the increased consumption of foods rich in saturated fats and added sugars have exposed the general population to emerging health problems.
   The prevalence of metabolic syndrome (MS), composed of a cluster of factors as obesity, dyslipidemia, hyperglycemia, and hypertension, is rapidly increasing in industrialized and developing countries leading to precocious onset of age-related diseases. Indeed, oxidative stress, accumulation of advanced glycation endproducts, and a chronic low-grade inflammation are common features of MS and physiological ageing. In particular, the entire set of MS factors contributes to the development of an inflammatory status named metaflammation, which has been associated with activation of early innate immune response through the as sembling of the multiprotein complex inflammasome. The most investigated family of inflammasome platforms is the NOD-like receptor pyridine containing (NLRP) 3, which is activated by several exogenous and endogenous stimuli, leading to the sequential cleavage of caspase-1 and IL-1 beta, followed by secretion of active IL-1 beta. We here collect the most recent findings on NLRP3 activation in MS providing evidence of its central role in disease progression and organ dysfunction in target tissues of metaflammation, in particular in cardiovascular, hepatic and renal complications, with a focus on oxidative stress and advanced glycation endproducts. A wide overview of the most promising strategies for the modulation of NLRP3 activation and related metabolic repercussions is also provided, since the finding of specific pharmacological tools is an urgent requirement to reduce the social and economic burden of MS- and elderly-associated diseases.
C1 [Mastrocola, Raffaella; Aragno, Manuela; Penna, Claudia; Pagliaro, Pasquale] Univ Turin, Dept Clin & Biol Sci, Turin, Italy.
   [Alloatti, Giuseppe] Univ Turin, Dept Life Sci & Syst Biol, Turin, Italy.
   [Collino, Massimo] Univ Turin, Dept Drug Sci & Technol, Via P Giuria 9, I-10125 Turin, Italy.
C3 University of Turin; University of Turin; University of Turin
RP Collino, M (corresponding author), Univ Turin, Dept Drug Sci & Technol, Via P Giuria 9, I-10125 Turin, Italy.
EM massimo.collino@unit.it
RI Penna, Claudia/J-5103-2018; Collino, Massimo/AAK-8532-2020; Pagliaro,
   Pasquale/E-5239-2010
OI ARAGNO, Manuela/0000-0002-0453-5235; Pagliaro,
   Pasquale/0000-0002-4386-1383
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PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
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OA Green Submitted
DA 2025-06-11
ER

PT J
AU Kolinsky, NC
   Weare-Regales, N
   Lockey, RF
AF Kolinsky, Nicholas C.
   Weare-Regales, Natalia
   Lockey, Richard F.
TI A Practical Approach to Assist Asthmatics to Lose Weight
SO JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
LA English
DT Review
DE Asthma; Obesity; Weight loss; Diet; Exercise; Bariatric surgery; Weight
   gain; Weight loss medication
ID CLINICAL-PRACTICE GUIDELINES; BODY-MASS INDEX; BARIATRIC SURGERY;
   AMERICAN ASSOCIATION; LOSS MAINTENANCE; OBESITY; OVERWEIGHT;
   ENDOCRINOLOGISTS; INTERVENTION; EPIDEMIOLOGY
AB Treating patients with obesity, particularly asthmatics, is a complex challenge that requires a unique and individually tailored approach. Obesity, defined by the Centers for Disease Control and Prevention, is a body mass index of 30.0 kg/m(2) or greater. It affects approximately 43% of adults and 19% of youth in America. It is a multifactorial disease and should be managed with the same intensity as any other medical problem, for it represents a risk factor for the onset and severity of asthma. Furthermore, it is a comorbid condition that exacerbates rhinosinusitis, gastroesophageal reflux disease, obstructive sleep apnea, hypertension, anxiety, and depression. Being obese also increases morbidity for cardio/cerebrovascular diseases, metabolic syndrome, type 2 diabetes, breast and bladder cancer, and migraines. Osteoarthritis, in particular, of the knees and hips, is also associated with obesity, and that too will complicate asthma by hindering a subject's mobility and ability to exercise. This paper reviews the epidemiology and pathophysiology of obesity, its effect on asthma, and practical strategies to achieve weight loss. (C) 2021 American Academy of Allergy, Asthma & Immunology
C1 [Kolinsky, Nicholas C.; Lockey, Richard F.] Univ S Florida, Div Allergy & Immunol, Dept Internal Med, Morsani Coll Med, Tampa, FL 33620 USA.
   [Weare-Regales, Natalia] Univ S Florida, Div Endocrinol Diabet & Metab, Dept Internal Med, Morsani Coll Med, Tampa, FL 33620 USA.
C3 State University System of Florida; University of South Florida; State
   University System of Florida; University of South Florida
RP Kolinsky, NC (corresponding author), Univ S Florida, Morsani Coll Med, 13000 Bruce B Downs Blvd,Suite IIID, Tampa, FL 33612 USA.
EM nkolinsky@usf.edu
RI WeareRegales, Natalia/KWU-1222-2024
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DA 2025-06-11
ER

PT J
AU Velehorschi, C
   Bleau, P
   Vermani, M
   Furtado, M
   Klassen, LJ
AF Velehorschi, Corina
   Bleau, Pierre
   Vermani, Monica
   Furtado, Melissa
   Klassen, Larry J.
TI Understanding the role of adjunctive nonpharmacological therapies in
   management of the multiple pathways to depression
SO PSYCHIATRY RESEARCH
LA English
DT Review
DE Metabolic syndrome; Adjunct therapy; Somatic therapies; Psychotherapy;
   Major depressive disorder
ID ST JOHNS WORT; SEROTONIN REUPTAKE INHIBITORS; NONSEASONAL MAJOR
   DEPRESSION; CANMAT CLINICAL GUIDELINES; METABOLIC SYNDROME; COGNITIVE
   THERAPY; BRIGHT LIGHT; DOUBLE-BLIND; SELF-HELP; INTERPERSONAL
   PSYCHOTHERAPY
AB Major depressive disorder (MDD) is a common disorder with a lifetime prevalence of 16.2% and the fourth highest cause of disability globally. It is hypothesized to be a syndromatic manifestation of multiple pathological processes leading to similar clinical manifestation. MDD is associated with at least three categories of peripheral hormone-type factors including neurotrophic factors, proinflammatory cytokines, and processes that impair regulation of the hypothalamic-pituitary-adrenocortical axis. Neuroimaging studies have identified functional abnormalities including subcortical systems associated with reward and emotion processing, medial prefrontal and anterior cingulate cortical regions and the lateral prefrontal cortical systems involved in cognitive control and voluntary emotion regulation. Studies investigating the effects of psychotherapy and pharmacotherapy on functional brain measures show normalization of brain function with return to euthymia. Nevertheless, approximately 50% of patients with MDD will not respond sufficiently and 60 to 70% will not achieve full remission with first-line pharmacotherapy, therefore clinicians strive to improve patient responses through the use of adjunct therapies. This review discusses recent research in the various biological processes associated with MDD as well as recent data in support of the use of adjunctive non-pharmacological therapies including psychotherapy, bibliotherapy, Internet therapy, "natural" or herbal approaches, exercise therapy, and somatic therapies. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
C1 [Velehorschi, Corina] Windsor Reg Hosp, Toldo Neurobehav Inst, Windsor, ON, Canada.
   [Velehorschi, Corina] Western Univ, Schulich Sch Med, London, ON, Canada.
   [Bleau, Pierre] McGill Univ, Fac Med, Montreal, PQ, Canada.
   [Bleau, Pierre] McGill Univ, Ctr Hlth, Montreal, PQ, Canada.
   [Vermani, Monica; Furtado, Melissa] START Clin Mood & Anxiety Disorders, Toronto, ON, Canada.
   [Vermani, Monica] Lakehead Univ, Dept Psychol, Thunder Bay, ON P7B 5E1, Canada.
   [Klassen, Larry J.] Eden Mental Hlth Ctr, Winkler, MB, Canada.
C3 Western University (University of Western Ontario); McGill University;
   McGill University; Lakehead University
RP Velehorschi, C (corresponding author), Neurobehav Inst, 1453 Prince Rd, Windsor, ON N9C 3Z4, Canada.
EM corina_velehorschi@wrh.on.ca
FU Valeant Canada Ltd.
FX Publication costs associated with this supplement were paid to Elsevier
   by Valeant Canada Ltd.
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NR 116
TC 12
Z9 12
U1 1
U2 31
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0165-1781
EI 1872-7123
J9 PSYCHIAT RES
JI Psychiatry Res.
PD DEC
PY 2014
VL 220
SU 1
BP S34
EP S44
PG 11
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA CA5LL
UT WOS:000348949800004
PM 25539873
DA 2025-06-11
ER

PT J
AU Lehto, SM
   Huotari, A
   Niskanen, L
   Herzig, KH
   Tolmunen, T
   Viinamäki, H
   Koivumaa-Honkanen, H
   Honkalampi, K
   Sinikallio, S
   Ruotsalainen, H
   Hintikka, J
AF Lehto, Soili M.
   Huotari, Anne
   Niskanen, Leo
   Herzig, Karl-Heinz
   Tolmunen, Tommi
   Viinamaki, Heimo
   Koivumaa-Honkanen, Heli
   Honkalampi, Kirsi
   Sinikallio, Sanna
   Ruotsalainen, Heli
   Hintikka, Jukka
TI Serum IL-7 and G-CSF in major depressive disorder
SO PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
LA English
DT Review
DE G-CSF; Growth factors; IL-7; Inflammation; Major depressive disorder
ID TORONTO-ALEXITHYMIA-SCALE; COLONY-STIMULATING FACTOR; METABOLIC
   SYNDROME; T-CELLS; CYTOKINES; INFLAMMATION; INTERLEUKIN-7;
   PATHOPHYSIOLOGY; EXPRESSION; IMMUNITY
AB Major depressive disorder (MDD) has been associated with dysregulated immune systems and impaired T cell function, but data on depression-related alterations in the levels of immunomodulatory growth factors are scarce. In order to further clarify the mechanisms underlying immune system dysregulation in depressed subjects, we examined the associations between MDD and serum levels of two immunomodulatory growth factors, interleukin (IL)-7 and granulocyte-colony stimulating factor (G-CSF), in 122 subjects (MDD with long-term symptomatology, n = 61; controls, n = 61). The MOD subjects had lowered levels of IL-7. In a model adjusted for age, gender and body mass index, subjects in the lowest tertile of IL-7 had a 3.4-fold increased likelihood for MDD (p = 0.010). Further adjustments for sleep disturbances, alcohol use, smoking, and metabolic syndrome did not alter these findings. Moreover, the exclusion of subjects with rheumatoid arthritis, coronary heart disease, or the use of non-steroidal anti-inflammatory medications or oral corticosteroids only slightly attenuated the findings. The G-CSF levels did not differ between the two groups. The lowering of the serum levels of IL-7, a regulator of T cell homeostasis, in MDD subjects may underlie the depression-related impaired T cell function. (C) 2010 Elsevier Inc. All rights reserved.
C1 [Lehto, Soili M.; Herzig, Karl-Heinz; Tolmunen, Tommi; Viinamaki, Heimo; Koivumaa-Honkanen, Heli; Hintikka, Jukka] Kuopio Univ Hosp, Dept Psychiat, SF-70210 Kuopio, Finland.
   [Lehto, Soili M.; Niskanen, Leo; Herzig, Karl-Heinz; Tolmunen, Tommi; Viinamaki, Heimo; Koivumaa-Honkanen, Heli; Hintikka, Jukka] Univ Eastern Finland, Kuopio, Finland.
   [Huotari, Anne; Herzig, Karl-Heinz] Univ Kuopio, Dept Pharmaceut, FIN-70211 Kuopio, Finland.
   [Huotari, Anne; Herzig, Karl-Heinz; Ruotsalainen, Heli] Univ Oulu, Inst Biomed, Div Physiol & Bioctr Oulu, Oulu, Finland.
   [Niskanen, Leo] Kuopio Univ Hosp, Dept Med, SF-70210 Kuopio, Finland.
   [Koivumaa-Honkanen, Heli] Univ Oulu, Dept Clin Med, Oulu, Finland.
   [Koivumaa-Honkanen, Heli] Lapland Hosp Dist, Dept Psychiat, Rovaniemi 97140, Finland.
   [Honkalampi, Kirsi] Kuopio Psychiat Ctr, Kuopio, Finland.
   [Sinikallio, Sanna] Kuopio Univ Hosp, Dept Rehabil, SF-70210 Kuopio, Finland.
C3 University of Eastern Finland; University of Eastern Finland Hospital;
   Kuopio University Hospital; University of Eastern Finland; University of
   Eastern Finland; University of Oulu; University of Eastern Finland;
   University of Eastern Finland Hospital; Kuopio University Hospital;
   University of Oulu; Kuopio University Hospital; University of Eastern
   Finland; University of Eastern Finland Hospital
RP Lehto, SM (corresponding author), Kuopio Univ Hosp, Dept Psychiat, SF-70210 Kuopio, Finland.
EM Soili.Lehto@kuh.fi
RI Koivumaa-Honkanen, Heli/L-1274-2015
OI Lehto, Soili/0000-0003-4324-6679; Ruotsalainen, Heli/0000-0003-4923-5196
FU Kuopio University Hospital; Academy of Finland [116996]; Academy of
   Finland (AKA) [116996] Funding Source: Academy of Finland (AKA)
FX The authors thank Kaisa Haatainen, Ph.D., and Tarja Saharinen, M.N.Sc.,
   for their valuable contribution to the KUDEP study. SML was supported by
   Kuopio University Hospital EVO funding. HK-H was supported by the
   Academy of Finland (grant 116996).
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NR 51
TC 33
Z9 35
U1 0
U2 6
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0278-5846
EI 1878-4216
J9 PROG NEURO-PSYCHOPH
JI Prog. Neuro-Psychopharmacol. Biol. Psychiatry
PD AUG 16
PY 2010
VL 34
IS 6
BP 846
EP 851
DI 10.1016/j.pnpbp.2010.03.033
PG 6
WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA 642EX
UT WOS:000281187800006
PM 20382196
DA 2025-06-11
ER

PT J
AU Doretto, L
   Mari, FC
   Chaves, AC
AF Doretto, Larissa
   Mari, Flora Chaves
   Chaves, Ana Cristina
TI Polycystic Ovary Syndrome and Psychotic Disorder
SO FRONTIERS IN PSYCHIATRY
LA English
DT Review
DE polycystic ovary syndrome; psychotic disorder; women; antipsychotic
   drugs; schizophrenia
ID TYPE-2 DIABETES-MELLITUS; PSYCHIATRIC-DISORDERS; ANTIPSYCHOTIC-DRUGS;
   METABOLIC SYNDROME; RISK; WOMEN; SCHIZOPHRENIA; PREVALENCE;
   PATHOPHYSIOLOGY; INFERTILITY
AB Polycystic ovary syndrome (PCOS), a disease that usually emerges during adolescence, is characterized by hormonal imbalance and ovarian dysfunction. The prevalence can vary between 5.6 to 21.3% in women and 6% in adolescent girls. This discrepancy is related to the population studied and the diagnostic criteria used. The underlying pathophysiology of PCOS is not fully understood, but it can lead to a number of co-morbidities, including hypertension, diabetes, dyslipidemia, and also, mental health disorders. Clinical and preclinical data indicate neuroendocrine involvement with dysfunction in gamma-Aminobutyric acid (GABA) signaling and neuronal androgen receptors that might reduce hypothalamic sensitivity and lead to an impairment of estradiol and progesterone feedback. Based on these assumptions, the aims of this paper are to review the association of PCOS and psychotic disorders in order to address the burden of women comorbid for both conditions.
C1 [Doretto, Larissa; Chaves, Ana Cristina] Univ Fed Sao Paulo UNIFESP, Dept Psychiat, Episode Psychosis Program 1, Sao Paulo, Brazil.
   [Mari, Flora Chaves] Santa Casa Med Sch Sao Paulo, Sao Paulo, Brazil.
C3 Universidade Federal de Sao Paulo (UNIFESP)
RP Chaves, AC (corresponding author), Univ Fed Sao Paulo UNIFESP, Dept Psychiat, Episode Psychosis Program 1, Sao Paulo, Brazil.
EM anachaves@terra.com.br
RI Chaves, Ana/A-5329-2012
OI Chaves, Ana Cristina/0000-0002-7777-5598
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NR 49
TC 25
Z9 26
U1 0
U2 12
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-0640
J9 FRONT PSYCHIATRY
JI Front. Psychiatry
PD JUN 10
PY 2020
VL 11
AR 543
DI 10.3389/fpsyt.2020.00543
PG 6
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA MD3QM
UT WOS:000543885700001
PM 32587538
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Al-Gayyar, MMH
   Shams, MEE
   Barakat, EAME
AF Al-Gayyar, Mohammed M. H.
   Shams, Mohamed E. E.
   Barakat, Enaase A. M. E.
TI Fish oil improves lipid metabolism and ameliorates inflammation in
   patients with metabolic syndrome: Impact of nonalcoholic fatty liver
   disease
SO PHARMACEUTICAL BIOLOGY
LA English
DT Article
DE Fatty liver; metabolic syndrome; fish oil; lipid profile; oxidative
   stress; antioxidants; TNF-alpha and IL-6
ID INSULIN-RESISTANCE; OBESE-PATIENTS; STEATOHEPATITIS; ALPHA;
   PATHOGENESIS; PREVALENCE; MANAGEMENT; STEATOSIS; EXPOSURE; NECROSIS
AB Context: Nonalcoholic fatty liver disease (NAFLD) is increasingly prevalent in Egypt, in parallel with increasing obesity. NAFLD can lead to liver inflammation, fibrosis and cirrhosis. NAFLD appears tightly linked with metabolic syndrome (MetS).
   Objective: Examine the impact of dietary fish oil on human patients with MetS and NAFLD.
   Materials and methods: One hundred and forty patients were enrolled in the current study and classified into two groups: patients with both MetS and NAFLD and patients with MetS alone. Sixty-four patients were treated with daily supplementation of 2 g of fish oil for 6 months. Markers of hyperlipidemia and oxidative stress, hydrogen peroxide (H2O2) and malondialdhyde (MDA), as well as proinflammatory cytokines, tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6), were analyzed.
   Results: Patients without fish oil exhibited significant increases in triglycerides (TGs), low-density lipoprotein (LDL), H2O2 and MDA that were associated with significantly elevated TNF-alpha and IL-6 compared to controls. Furthermore, patients with both NAFLD and MetS showed significant increase in H2O2, MDA, TNF-alpha and IL-6 levels compared with MetS group (p < 0.05). Treatment with fish oil reduced serum level of TG, LDL-cholesterol (LDL-C), H2O2, MDA, TNF-alpha and IL-6 levels in patients and did not affect the control levels.
   Discussion and conclusion: Patients with NAFLD had bad lipid profile through a mechanism that involved developed redox imbalance, characterized by boosted free-radical activity and lipid peroxidation enhancing the release of proinflammatory cytokines leading to increased MetS risk and liver damage. However, daily treatment of patients with fish oil for 6 months improved lipid profile and blocked the oxidative stress and cytokines release.
C1 [Al-Gayyar, Mohammed M. H.] Univ Georgia, Coll Pharm, Program Clin & Expt Therapeut, Augusta, GA 30912 USA.
   [Al-Gayyar, Mohammed M. H.] Univ Mansoura, Dept Biochem, Fac Pharm, Mansoura, Egypt.
   [Al-Gayyar, Mohammed M. H.] Charlie Norwood Vet Affairs Med Ctr, Augusta, GA USA.
   [Shams, Mohamed E. E.] Univ Mansoura, Dept Pharmaceut, Fac Pharm, Mansoura, Egypt.
   [Barakat, Enaase A. M. E.] Univ Mansoura, Dept Internal Med, Fac Med, Mansoura, Egypt.
C3 University System of Georgia; University of Georgia; Egyptian Knowledge
   Bank (EKB); Mansoura University; US Department of Veterans Affairs;
   Veterans Health Administration (VHA); Charlie Norwood VA Medical Center;
   Egyptian Knowledge Bank (EKB); Mansoura University; Egyptian Knowledge
   Bank (EKB); Mansoura University
RP Al-Gayyar, MMH (corresponding author), Univ Georgia, Coll Pharm, Program Clin & Expt Therapeut, 1120 15th St,HM-1200, Augusta, GA 30912 USA.
EM mhgayyar@yahoo.com
RI Shams, Mohamed/AAB-5990-2020; Al-Gayyar, Mohammed/E-8250-2014
OI Al-Gayyar, Mohammed/0000-0003-4777-3919; Shams, Mohamed E.
   E./0000-0003-2392-2852
CR Al-Gayyar MMH, 2007, J PHARM PHARMACOL, V59, P409, DOI 10.1211/jpp.59.3.0011
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NR 30
TC 19
Z9 21
U1 0
U2 16
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 1388-0209
J9 PHARM BIOL
JI Pharm. Biol.
PD MAR
PY 2012
VL 50
IS 3
BP 297
EP 303
DI 10.3109/13880209.2011.604088
PG 7
WC Plant Sciences; Medical Laboratory Technology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Medical Laboratory Technology; Pharmacology & Pharmacy
GA 891ZW
UT WOS:000300256800006
PM 22103753
OA Bronze
DA 2025-06-11
ER

PT J
AU Mehta, PK
   Huang, JW
   Levit, RD
   Malas, W
   Waheed, N
   Merz, CNB
AF Mehta, Puja K.
   Huang, Jingwen
   Levit, Rebecca D.
   Malas, Waddah
   Waheed, Nida
   Merz, C. Noel Bairey
TI Ischemia and no obstructive coronary arteries (INOCA): A narrative
   review
SO ATHEROSCLEROSIS
LA English
DT Review
DE Coronary microvascular; Coronary vasospasm; Myocardial ischemia;
   Endothelial dysfunction
ID INDUCED MYOCARDIAL-ISCHEMIA; ENHANCED EXTERNAL COUNTERPULSATION; CARDIAC
   SYNDROME-X; COMPUTED-TOMOGRAPHY ANGIOGRAPHY; LEFT-VENTRICULAR FUNCTION;
   AUTONOMIC NERVOUS-SYSTEM; STELLATE GANGLION BLOCK;
   HEART-RATE-VARIABILITY; FLOW VELOCITY RESERVE; QUALITY-OF-LIFE
AB Myocardial ischemia with no obstructive coronary arteries (INOCA) is a chronic coronary syndrome condition that is increasingly being recognized as a substantial contributor to adverse cardiovascular mortality and out-comes, including myocardial infarction and heart failure with preserved ejection fraction (HFpEF). While INOCA occurs in both women and men, women are more likely to have the finding of INOCA and are more adversely impacted by angina, with recurrent hospitalizations and a lower quality of life with this condition. Abnormal epicardial coronary vascular function and coronary microvascular dysfunction (CMD) have been identified in a majority of INOCA patients on invasive coronary function testing. CMD can co-exist with obstructive epicardial coronary artery disease (CAD), diffuse non-obstructive epicardial CAD, and with coronary vasospasm. Epicardial vasospasm can also occur with normal coronary arteries that have no atherosclerotic plaque on intravascular imaging. While all predisposing factors are not clearly understood, cardiometabolic risk factors, and endothelium dependent and independent mechanisms that increase oxidative stress and inflammation are associated with microvascular injury, CMD and INOCA. Cardiac autonomic dysfunction has also been implicated in abnormal vasoreactivity and persistent symptoms. INOCA is under-recognized and under-diagnosed, partly due to the heterogenous patient populations and mechanisms. However, diagnostic testing methods are available to guide INOCA management. Treatment of INOCA is evolving, and focuses on cardiac risk factor control, improving ischemia, reducing atherosclerosis progression, and improving angina and quality of life. This review focuses on INOCA, relations to HFpEF, available diagnostics, current and investigational therapeutic strategies, and knowledge gaps in this condition.
C1 [Mehta, Puja K.] Emory Univ, Sch Med, Emory Womens Heart Ctr, Div Cardiol, Atlanta, GA USA.
   [Mehta, Puja K.] Emory Univ, Sch Med, Emory Clin Cardiovasc Res Inst, Div Cardiol, Atlanta, GA USA.
   [Huang, Jingwen] Emory Univ, Sch Med, J Willis Hurst Internal Med Residency Training Pro, Atlanta, GA USA.
   [Levit, Rebecca D.] Emory Univ, Sch Med, Div Cardiol, Atlanta, GA USA.
   [Malas, Waddah] Loyola Med Ctr, Cardiovasc Dis Fellowship Training Program, Chicago, IL USA.
   [Waheed, Nida] Emory Univ, Sch Med, Cardiovasc Dis Fellowship Training Program, Atlanta, GA USA.
   [Merz, C. Noel Bairey] Cedars Sinai Smidt Heart Inst, Barbra Streisand Womens Heart Ctr, Los Angeles, CA USA.
   [Mehta, Puja K.] Emory Clin Cardiovasc Res Inst, Emory Womens Heart Ctr, Womens Translat Cardiovasc Res, 1462 Clifton Rd,Suite 505, Atlanta, GA 30322 USA.
C3 Emory University; Emory University; Emory University; Emory University;
   Loyola University Chicago; Emory University; Cedars Sinai Medical Center
RP Mehta, PK (corresponding author), Emory Clin Cardiovasc Res Inst, Emory Womens Heart Ctr, Womens Translat Cardiovasc Res, 1462 Clifton Rd,Suite 505, Atlanta, GA 30322 USA.
EM pkmehta@emory.edu
RI Waheed, Nida/AAM-6077-2020; Huang, Jingwen/GWC-3188-2022
OI Mehta, Puja/0000-0002-5678-812X
FU National Institutes of Health [R01HL124649, U54 AG065141,
   1U54AG062334-01, 1R01HL157311]; Edythe L. Broad Fellowship; Constance
   Austin Women's Heart Research Fellowship; Cedars-Sinai Medical Center;
   Barbra Streisand Women's Cardiovascular Research and Education Program;
   Society for Women's Health Research (SWHR), Washington, DC; Linda Joy
   Pollin Women's Heart Health Program; Erika Glazer Women's Heart Health
   Project; Adelson Family Foundation, Cedars-Sinai Medical Center, Los
   Angeles, California
FX This work was supported by the National Institutes of Health
   R01HL124649, U54 AG065141, 1U54AG062334-01, 1R01HL157311, the Edythe L.
   Broad and the Constance Austin Women's Heart Research Fellowships,
   Cedars-Sinai Medical Center, the Barbra Streisand Women's Cardiovascular
   Research and Education Program, Cedars -Sinai Medical Center, The
   Society for Women's Health Research (SWHR), Washington, DC, the Linda
   Joy Pollin Women's Heart Health Program, the Erika Glazer Women's Heart
   Health Project, and the Adelson Family Foundation, Cedars-Sinai Medical
   Center, Los Angeles, California.
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NR 189
TC 55
Z9 58
U1 3
U2 12
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0021-9150
EI 1879-1484
J9 ATHEROSCLEROSIS
JI Atherosclerosis
PD DEC
PY 2022
VL 363
BP 8
EP 21
DI 10.1016/j.atherosclerosis.2022.11.009
EA NOV 2022
PG 14
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 7J2XP
UT WOS:000904447700002
PM 36423427
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Lupoli, R
   Calcaterra, I
   Ambrosino, P
   Giacco, R
   Vitale, M
   Della Pepa, G
   Rivellese, AA
   Iannuzzo, G
   Bozzetto, L
   Di Minno, M
AF Lupoli, Roberta
   Calcaterra, Ilenia
   Ambrosino, Pasquale
   Giacco, Rosalba
   Vitale, Marilena
   Della Pepa, Giuseppe
   Rivellese, Angela Albarosa
   Iannuzzo, Gabriella
   Bozzetto, Lutgarda
   Di Minno, Matteo
TI Effects of Mediterranean Diet on Endothelial Reactivity in Individuals
   with High Cardiometabolic Risk: A Randomized Controlled Parallel-Group
   Preliminary Trial
SO BIOMEDICINES
LA English
DT Article
DE mediterranean diet; endothelial function; inflammation; oxidative
   stress; cardiovascular risk; cardiovascular disability; chronic disease;
   exercise; lifestyle risk reduction; outcome
ID OLIVE OIL; INSULIN-RESISTANCE; BRACHIAL-ARTERY; DYSFUNCTION;
   INFLAMMATION; REHABILITATION; ANTIOXIDANTS; POLYPHENOLS; IMPROVEMENT;
   GUIDELINES
AB Background: Endothelial dysfunction is recognized as an early modification involved in the pathogenesis of vascular diseases. Evidence suggests that the Mediterranean Diet (MD) is associated with endothelial function improvement and, in turn, plays an important role in atherosclerosis development and progression. Objectives: To evaluate both acute and sustained effects of the MD on endothelial function in patients with high cardiometabolic risk. Methods: A total of 25 subjects were randomly assigned to either the MD group or the Control Diet (CD) group according to a single-blind, parallel-group study design. Endothelial function was evaluated through non-invasive flow-mediated dilation (FMD) measurements at baseline (T0) and after 8 weeks (Tw8) of the MD or CD intervention, under both 12 h fast condition (fasting) and 2 h post-meal resembling the assigned diet (2 h). Assessments were conducted by a blinded sonographer. Results: FMD at T0-fasting was similar between MD and CD groups (6.11% +/- 0.67 vs. 7.90% +/- 1.65; p = 0.266). A significant difference in FMD between MD and CD groups was observed at T0-2h (12.14% +/- 1.93 vs. 4.01% +/- 1.03; p = 0.004), T8w-fasting (9.76% +/- 1.18 vs. 5.03% +/- 0.89; p = 0.008), and T8w-2h (8.99% +/- 1.22 vs. 3.86% +/- 0.52; p = 0.003). Oral glucose insulin sensitivity (OGIS) at T0 correlated with FMD percent changes from T0-fasting to T0-2h (r = 0.414, p = 0.044). After adjusting for age, gender, and OGIS, MD was an independent predictor of percent changes in FMD from T0-fasting to T0-2h (beta: -0.582, p = 0.003), from T0-fasting to T8w-fasting (beta: -0.498, p = 0.013), and from T0-fasting to T8w-2h (beta: -0.479, p = 0.018). Conclusions: Adherence to the MD may improve endothelial function in both the short- and medium-term among patients at high cardiometabolic risk.
C1 [Lupoli, Roberta] Univ Naples Federico II, Dept Mol Med & Med Biotechnol, I-80131 Naples, Italy.
   [Calcaterra, Ilenia; Vitale, Marilena; Della Pepa, Giuseppe; Rivellese, Angela Albarosa; Iannuzzo, Gabriella; Bozzetto, Lutgarda; Di Minno, Matteo] Univ Naples Federico II, Dept Clin Med & Surg, I-80131 Naples, Italy.
   [Ambrosino, Pasquale] Ist Clin Sci Maugeri IRCCS, Sci Directorate Telese Terme Inst, I-82037 Telese Terme, Italy.
   [Giacco, Rosalba] CNR, Inst Food Sci, I-83100 Avellino, Italy.
C3 University of Naples Federico II; University of Naples Federico II;
   Consiglio Nazionale delle Ricerche (CNR); Istituto di Scienze dell'
   Alimentazione (ISA-CNR)
RP Ambrosino, P (corresponding author), Ist Clin Sci Maugeri IRCCS, Sci Directorate Telese Terme Inst, I-82037 Telese Terme, Italy.
EM roberta.lupoli@unina.it; ilenialorenza.calcaterra@unina.it;
   pasquale.ambrosino@icsmaugeri.it; rosalba.giacco@isa.cnr;
   marilena.vitale@unina.it; giuseppe.dellapepa@unina.it;
   rivelles@unina.it; gabriella.iannuzzo@unina.it;
   lutgarda.bozzetto@unina.it; matteo.diminno@unina.it
RI Bozzetto, Lutgarda/E-6271-2012; iannuzzo, Gabriella/ABH-3527-2020; Della
   Pepa, Giuseppe/AAK-5488-2020; Calcaterra, Ilenia/AAH-6666-2020; Vitale,
   Marilena/J-1457-2014; Ambrosino, Pasquale/AAD-1934-2020; Di Minno,
   Matteo/D-5141-2012
OI Calcaterra, Ilenia/0000-0001-8077-2809; Vitale,
   Marilena/0000-0001-9951-4674; Ambrosino, Pasquale/0000-0002-9398-0428;
   Di Minno, Matteo/0000-0001-8059-3819
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NR 55
TC 1
Z9 1
U1 2
U2 2
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2227-9059
J9 BIOMEDICINES
JI Biomedicines
PD NOV
PY 2024
VL 12
IS 11
AR 2595
DI 10.3390/biomedicines12112595
PG 13
WC Biochemistry & Molecular Biology; Medicine, Research & Experimental;
   Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Research & Experimental Medicine;
   Pharmacology & Pharmacy
GA N8K9F
UT WOS:001366767900001
PM 39595161
OA gold
DA 2025-06-11
ER

PT J
AU da Silva, MM
   Gomes, MFP
   de Moura, EDC
   Veras, MM
   Kubota, MC
   Takano, AP
   dos Santos, ACC
   Jose, CGD
   Souza, GAD
   Cardoso, NM
   Estadella, D
   Lambertucci, RH
   Medeiros, A
AF da Silva, Monique Marques
   Pereira Gomes, Moises Felipe
   Carvalho de Moura, Elizabeth de Orleans
   Veras, Mariana Matera
   Kubota, Melina Chiemi
   Takano, Ana Paula
   Cardoso dos Santos, Ana Carolina
   dos Reis Jose, Carolina Goncalves
   da Silva Souza, Graziele Aparecida
   Cardoso, Naiara Magalhaes
   Estadella, Debora
   Lambertucci, Rafael Herling
   Medeiros, Alessandra
TI Aerobic exercise training combined or not with okra consumption as a
   strategy to prevent kidney changes caused by metabolic syndrome in
   Zucker rats
SO PLOS ONE
LA English
DT Article
ID ABELMOSCHUS-ESCULENTUS; OXIDATIVE STRESS; RENAL FIBROSIS; DISEASE;
   FATTY; OBESE; INFLAMMATION; NEPHROPATHY; SUPEROXIDE; RECEPTOR
AB The complications of Metabolic Syndrome (MetS) include kidney disease, and most dialysis patients are diagnosed with MetS. The benefit of exercise training (ET) for MetS treatment is already well defined in the literature, but the antidiabetic and antihyperlipidemic benefits of okra (O) have been discovered only recently. The aim of this study was to evaluate the effects of O and/or ET supplementation on renal function and histology; serum urea and creatinine value; inflammation (IL-6, IL-10, TNF-alpha) and oxidative stress in renal tissue. For this, 32 Zucker rats (fa/fa) were randomly separated into four groups of 8 animals each: Metabolic Syndrome (MetS), MetS + Okra (MetS + O), MetS + Exercise Training (MetS + ET), and MetS + Exercise Training and Okra (MetS + ET + O), and 8 Zucker lean (fa/+) rats comprised the Control group (CTL). Okra was administered by orogastric gavage 2x/day (morning and night, 100 mg/kg) and ET performed on the treadmill, at moderate intensity, 1h/day, 5x/week for 6 weeks. Although the renal function was not altered, the animals with MetS showed greater fibrotic deposition accompanied by a worse stage of renal injury, in addition to increased kidney weight. Although all interventions were beneficial in reducing fibrosis, only ET combined with O was able to improve the degree of renal tissue impairment. ET improved the anti-inflammatory status and reduced nitrite levels, but the combination of ET and O was more beneficial as regards catalase activity. Okra consumption alone did not promote changes in inflammatory cytokines and oxidative stress in the kidney. In conclusion, ET combined or not with O seems to be beneficial in preventing the progression of renal disease when renal function is not yet altered.
C1 [da Silva, Monique Marques; Pereira Gomes, Moises Felipe; Carvalho de Moura, Elizabeth de Orleans; Kubota, Melina Chiemi; Cardoso dos Santos, Ana Carolina; dos Reis Jose, Carolina Goncalves; da Silva Souza, Graziele Aparecida; Cardoso, Naiara Magalhaes; Estadella, Debora; Lambertucci, Rafael Herling; Medeiros, Alessandra] Univ Fed Sao Paulo, Interdisciplinary Grad Program Hlth Sci, Santos, SP, Brazil.
   [Veras, Mariana Matera; Takano, Ana Paula] Univ Sao Paulo, Dept Pathol, Lab Environm Air Pollut, Sch Med, Sao Paulo, Brazil.
   [Estadella, Debora; Lambertucci, Rafael Herling; Medeiros, Alessandra] Univ Fed Sao Paulo, Biosci Dept, Santos, SP, Brazil.
C3 Universidade Federal de Sao Paulo (UNIFESP); Universidade de Sao Paulo;
   Universidade Federal de Sao Paulo (UNIFESP)
RP Medeiros, A (corresponding author), Univ Fed Sao Paulo, Interdisciplinary Grad Program Hlth Sci, Santos, SP, Brazil.; Medeiros, A (corresponding author), Univ Fed Sao Paulo, Biosci Dept, Santos, SP, Brazil.
EM a.medeiros@unifesp.br
RI Takano, Ana/AAG-6514-2021; Gomes, Moisés/AGB-6281-2022; Lambertucci,
   Rafael/C-6975-2012; Estadella, Debora/G-5817-2012; Medeiros,
   Alessandra/E-8132-2012; VERAS, MARIANA/D-8575-2012
OI Marques da Silva, Monique/0000-0002-3376-6833; Felipe Pereira Gomes,
   Moises/0000-0003-3948-0497; Medeiros, Alessandra/0000-0002-7962-7185;
   VERAS, MARIANA/0000-0002-8363-4329; Cremasco Takano, Ana
   Paula/0000-0002-5057-1560
FU Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
   [2015/19893-0]; Conselho Nacional de Desenvolvimento e Tecnologico
   (CNPq) [305190/2018-0]; Coordenacao de Aperfeicoamento de Pessoal de
   Nivel Superior Brasil (CAPES) [001]
FX This study was funded by Fundacao de Amparo a Pesquisa do Estado de Sao
   Paulo (FAPESP #2015/19893-0) and Conselho Nacional de Desenvolvimento e
   Tecnologico (CNPq #305190/2018-0) in the form of grants to AM. This
   study was also funded by Coordenacao de Aperfeicoamento de Pessoal de Ni
   ' vel Superior Brasil (CAPES) -Finance Code 001 awarded to MMS.
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NR 57
TC 1
Z9 1
U1 1
U2 5
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PY 2022
VL 17
IS 6
AR e0269418
DI 10.1371/journal.pone.0269418
PG 21
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 3Y2OK
UT WOS:000843567600087
PM 35657982
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Du, FM
   Kuang, HY
   Duan, BH
   Liu, DN
   Yu, XY
AF Du, Fu-Man
   Kuang, Hong-Yu
   Duan, Bin-Hong
   Liu, Da-Na
   Yu, Xin-Yang
TI Effects of thyroid hormone and depression on common components of
   central obesity
SO JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
LA English
DT Article
DE Hypothyroidism; hyperthyroidism; depressive symptoms; obesity; body mass
   index; insulin resistance; total triglycerides; total cholesterol;
   low-density lipoprotein cholesterol
ID BODY-MASS INDEX; METABOLIC SYNDROME; SERUM THYROTROPIN; ASSOCIATIONS;
   ADOLESCENTS; CHILDREN
AB Objective We investigated the prevalence of abnormal thyroid function and depression in centrally obese participants, and to analyze the relationship of thyroid hormones and depression with components of central obesity. Methods We randomly selected 858 centrally obese participants and 500 non-obese controls in this study. For all participants, we measured serum free triiodothyronine (FT3), free thyroxine (FT4), thyroid-stimulating hormone (TSH), body mass index (BMI), waist-hip ratio (WHR), fasting blood glucose and insulin, homeostasis model assessment of insulin resistance (HOMA-IR), lipid concentrations, and blood pressure. Depression was assessed using the Center for Epidemiological Studies-Depression (CES-D) scale. Results Centrally obese participants had a higher prevalence of hypothyroidism and depression than non-obese controls. Serum FT4 levels negatively correlated with BMI and serum TSH levels and positively correlated with BMI, WHR, total triglycerides (TG), total cholesterol (TC), and low density lipoprotein cholesterol (LDL-C). After excluding participants with hypothyroidism and hyperthyroidism, serum FT4 levels showed negative correlation and serum TSH levels showed positive correlation with BMI in the remaining centrally obese participants. CES-D scores positively correlated with BMI. Conclusion We found high prevalences of hypothyroidism and depression among centrally obese participants. FT4 and TSH are important in weight regulation. Depression positively correlated with obesity.
C1 [Du, Fu-Man; Kuang, Hong-Yu; Liu, Da-Na; Yu, Xin-Yang] Harbin Med Univ, Affiliated Hosp 1, Dept Endocrinol, Harbin 150001, Heilongjiang, Peoples R China.
   [Du, Fu-Man; Duan, Bin-Hong] Heilongjiang Prov Hosp, Dept Endocrinol, Harbin, Heilongjiang, Peoples R China.
C3 Harbin Medical University
RP Kuang, HY (corresponding author), Harbin Med Univ, Affiliated Hosp 1, Dept Endocrinol, Harbin 150001, Heilongjiang, Peoples R China.
EM physiciankuang@outlook.com
RI yu, ellen/JSK-6301-2023
OI Du, Fuman/0000-0003-4961-4233
FU Health Commission of Heilongjiang Province [2016-504]
FX This study was supported by the Health Commission of Heilongjiang
   Province (Research project No. 2016-504).
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NR 35
TC 32
Z9 35
U1 0
U2 4
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0300-0605
EI 1473-2300
J9 J INT MED RES
JI J. Int. Med. Res.
PD JUL
PY 2019
VL 47
IS 7
BP 3040
EP 3049
DI 10.1177/0300060519851624
PG 10
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA IN3WH
UT WOS:000478606600026
PM 31144547
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU González-Domenech, CM
   Plaza-Andrades, IJ
   Garrido-Sanchez, L
   Queipo-Ortuño, MI
AF Maria Gonzalez-Domenech, Carmen
   Plaza-Andrades, Isaac J.
   Garrido-Sanchez, Lourdes
   Isabel Queipo-Ortuno, Maria
TI Synergic effect of metabolic syndrome and lipodystrophy on oxidative
   stress and inflammation process in treated HIV-patients
SO ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA
LA English
DT Article
DE Metabolic syndrome; Lipodystrophy; HIV; Protease inhibitors;
   Inflammation
ID INFECTED PATIENTS; ANTIRETROVIRAL THERAPY; PROTEASE INHIBITORS;
   DIABETES-MELLITUS; RISK-FACTORS; DISEASE; EVENTS; ADULTS; LIVER
AB The aim of this study was to assess the effect of lipodystrophy (LD) associated to metabolic syndrome (MS) on oxidative stress and inflammation in a cohort of 243 HIV-infected patients with MS, all of them under three different antiretroviral regimens. We collected immunovirological, biochemical and metabolic data, as well as anthropometric measurements. In addition, cardiovascular risk was also assessed by means of Atherogenic Index of Plasma (API) and Framingham Risk Score. The MS-LD patient set was characterized by a lower initial lymphocyte CD4 count and CD4/CD8 ratio and a higher initial viral load than the group without LD. We also found worse lipidic and glycaemic profiles (with lower HDL-cholesterol and higher triglyceride and glucose levels) in the MS-LD group. BMI, systolic blood pressure and Framingham score were significantly increased compared to MS-Non LD. In addition, patients with MS and LD had significantly higher levels of carbonylated proteins, lipid peroxidation, IL-6 and IL-8, as well as a significant decrease in the levels of leptin, adiponectin and antioxidant activities of catalase, super oxide dismutase and glutathione associated enzymes. In MS-LD HIV-1 patients, a significant negative correlation was found between Framingham Risk Score and the antioxidant biomarkers, however a positive association was found between API and protein-C reactive and carbonylated proteins. Segregating by ART, the above-mentioned conditions were worse within the MS-LD group whose treatment contained protease inhibitors, such as lopinavir. In conclusion, HIV-1 infected patients treated for at least six months, especially with regimens including PIs, showed a worsening of inflammatory process and oxidative stress. (C) 2020 Sociedad Espanola de Enfermedades Infecciosas y Microbiologia Clinica. Published by Elsevier Espana, S.L.U. All rights reserved.
C1 [Maria Gonzalez-Domenech, Carmen] Univ Malaga, Sci Coll, Microbiol Dept, Malaga, Spain.
   [Plaza-Andrades, Isaac J.; Garrido-Sanchez, Lourdes] UMA, Inst Invest Biomed Malaga IBIMA, Unidad Gest Clin Endocrinol & Nutr, Hosp Virgen de la Victoria, Malaga, Spain.
   [Isabel Queipo-Ortuno, Maria] CIMES UMA, Inst Invest Biomed Malaga IBIMA, Unidad Gest Clin Interctr Oncol Med, Hosp Univ Reg & Virgen de la Victoria, Malaga, Spain.
C3 Universidad de Malaga; Universidad de Malaga; Instituto de Investigacion
   Biomedica de Malaga y Plataforma en Nanomedicina (IBIMA); Universidad de
   Malaga; Instituto de Investigacion Biomedica de Malaga y Plataforma en
   Nanomedicina (IBIMA)
RP González-Domenech, CM (corresponding author), Univ Malaga, Sci Coll, Microbiol Dept, Malaga, Spain.; Garrido-Sanchez, L (corresponding author), UMA, Inst Invest Biomed Malaga IBIMA, Unidad Gest Clin Endocrinol & Nutr, Hosp Virgen de la Victoria, Malaga, Spain.
EM cmgodo@uma.es; lourgarrido@gmail.com
RI Ortuño, María/AAC-1238-2021; GONZALEZ DOMENECH, CARMEN MARIA/F-6068-2019
OI GONZALEZ DOMENECH, CARMEN MARIA/0000-0001-8248-3904; Garrido-Sanchez,
   Lourdes/0000-0003-0756-9606; QUEIPO ORTUNO, MARIA
   ISABEL/0000-0002-2867-0845
FU Spanish Ministry of Science and Innovation [SAF 2010-17213]; Regional
   Ministry of Health from the Andalusian Government [SAS 111226,
   C-0030-2018, C-0028-2018]; ISCIII [CPI13/00003, CPII18/00030]; European
   Regional Development Fund (ERDF)
FX This work was supported by the Spanish Ministry of Science and
   Innovation [SAF 2010-17213]; the Regional Ministry of Health from the
   Andalusian Government [SAS 111226]; "Miguel Servet Type II" grant
   [CPI13/00003 to M.I.Q.O. and CPII18/00030 to L.G.S.] from ISCIII,
   co-funded by the European Regional Development Fund (ERDF); "Nicolas
   Monardes" research program from the Regional Ministry of Health from the
   Andalusian Government [C-0030-2018 to M.I.Q.O. and C-0028-2018 to
   L.G.S.].
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   World Health Organization, 2017, CHIK VIR FACTSH
NR 41
TC 3
Z9 3
U1 0
U2 6
PU EDICIONES DOYMA S A
PI BARCELONA
PA TRAV DE GRACIA 17-21, 08021 BARCELONA, SPAIN
SN 0213-005X
EI 1578-1852
J9 ENFERM INFEC MICR CL
JI Enferm. Infec. Microbiol. Clin.
PD JUN-JUL
PY 2022
VL 40
IS 6
BP 310
EP 316
DI 10.1016/j.eimc.2020.11.019
EA JUN 2022
PG 7
WC Infectious Diseases; Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases; Microbiology
GA 3J6BL
UT WOS:000833478500005
PM 35680349
OA Green Accepted
DA 2025-06-11
ER

PT J
AU El Midaoui, A
   Fantus, IG
   Boughrous, AA
   Couture, R
AF El Midaoui, Adil
   Fantus, I. George
   Boughrous, Ali Ait
   Couture, Rejean
TI Beneficial Effects of Alpha-Lipoic Acid on Hypertension, Visceral
   Obesity, UCP-1 Expression and Oxidative Stress in Zucker Diabetic Fatty
   Rats
SO ANTIOXIDANTS
LA English
DT Article
DE type 2 diabetes; metabolic syndrome; insulin resistance; visceral
   obesity; hypertension; oxidative stress; alpha-lipoic acid
ID ENHANCED SUPEROXIDE-PRODUCTION; INSULIN-RESISTANCE; ADIPOSE-TISSUE;
   NADH/NADPH OXIDASE; GLUCOSE-METABOLISM; DYSFUNCTION; MECHANISM;
   INFLAMMATION; ADIPOCYTES; GLYCATION
AB Evidence suggests that oxidative stress plays a major role in the development of metabolic syndrome. This study aims to investigate whether alpha-lipoic acid (LA), a potent antioxidant, could exert beneficial outcomes in Zucker diabetic fatty (ZDF) rats. Male 6-week-old ZDF rats and their lean counterparts (ZL) were fed for six weeks with a standard diet or a chow diet supplemented with LA (1 g/kg feed). At 12 weeks of age, ZDF rats exhibited an increase in systolic blood pressure, epididymal fat weight per body weight, hyperglycemia, hyperinsulinemia, insulin resistance (HOMA index), adipocyte hypertrophy and a rise in basal superoxide anion (O-2 center dot(-)) production in gastrocnemius muscle and a downregulation of epididymal uncoupled protein-1 (UCP-1) protein staining. Treatment with LA prevented the development of hypertension, the rise in whole body weight and O-2 center dot(-) production in gastrocnemius muscle, but failed to affect insulin resistance, hyperglycemia and hyperinsulinemia in ZDF rats. LA treatment resulted in a noticeable increase of pancreatic weight and a further adipocyte hypertrophy, along with a decrease in epididymal fat weight per body weight ratio associated with an upregulation of epididymal UCP-1 protein staining in ZDF rats. These findings suggest that LA was efficacious in preventing the development of hypertension, which could be related to its antioxidant properties. The anti-visceral obesity effect of LA appears to be mediated by its antioxidant properties and the induction of UCP-1 protein at the adipose tissue level in ZDF rats. Disorders of glucose metabolism appear, however, to be mediated by other unrelated mechanisms in this model of metabolic syndrome.
C1 [El Midaoui, Adil; Couture, Rejean] Univ Montreal, Fac Med, Dept Pharmacol & Physiol, Montreal, PQ H3C 3J7, Canada.
   [El Midaoui, Adil; Boughrous, Ali Ait] Moulay Ismail Univ Meknes, Fac Sci & Tech Errachidia, Dept Biol, Res Team Biol Environm & Hlth, Errachidia 52000, Morocco.
   [Fantus, I. George] McGill Univ, Hlth Ctr Res Inst, Dept Med, Div Endocrinol & Metab, Montreal, PQ H4A 3J1, Canada.
C3 Universite de Montreal; Moulay Ismail University of Meknes; McGill
   University
RP El Midaoui, A (corresponding author), Univ Montreal, Fac Med, Dept Pharmacol & Physiol, Montreal, PQ H3C 3J7, Canada.; El Midaoui, A (corresponding author), Moulay Ismail Univ Meknes, Fac Sci & Tech Errachidia, Dept Biol, Res Team Biol Environm & Hlth, Errachidia 52000, Morocco.
EM adil.el.midaoui@umontreal.ca; george.fantus@mcgill.ca;
   boughrous@gmail.com; rejean.couture@umontreal.ca
RI Fantus, Ivan/E-8973-2010
FU Canadian Institutes of Health Research (CIHR) [MOP-119329]; Membrane
   Protein Biophysics Group (GEPROM) of the Universite de Montreal
FX This work was supported by Grants (to R.C.) from the Canadian Institutes
   of Health Research (CIHR, MOP-119329) and the Membrane Protein
   Biophysics Group (GEPROM) of the Universite de Montreal. The funders had
   no role in the design, analysis or writing of this article.
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NR 51
TC 14
Z9 14
U1 0
U2 3
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD DEC
PY 2019
VL 8
IS 12
AR 648
DI 10.3390/antiox8120648
PG 11
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA KB6WN
UT WOS:000506633000081
PM 31888243
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Bhutia, RD
   Sherpa, ML
   Singh, TA
   Khandelwal, B
AF Bhutia, Rinchen Doma
   Sherpa, Mingma Lhamu
   Singh, T. A.
   Khandelwal, Bidita
TI Oxidative stress in metabolic syndrome & its association with DNA-strand
   break
SO INDIAN JOURNAL OF MEDICAL RESEARCH
LA English
DT Article
DE DNA-strand break; hydrogen peroxide; metabolic syndrome; oxidative
   stress; ROS
ID HYDROGEN-PEROXIDE; DAMAGE; CANCER; PROTEIN; MODEL; ASSAY; RISK
AB Background & objectives: Oxidative stress (OS) is associated with numerous components of metabolic syndrome (MetS). This study was aimed to investigate if hydrogen peroxide (H2O2) as the reactive oxygen species was capable of depicting OS in MetS, and If MetS patients showed DNA damage in the form of DNA strand breaks (DSB).
   Methods: A total of 160 participants (90 males, 70 females) >= 20 yr of age were categorized into four groups based on the number of MetS risk parameters (n=40 in each group). Sugar and lipid profile, H2O2 concentration in blood and DNA-strand breaks were measured.
   Results: DSB was significantly more in those with MetS (n=40) than those without (n=120) whereas H2O2 levels were the same in both the study groups. The number of DSB differed significantly between the control and 3 risk factor groups. DSB was also higher in groups with 2 and 1 risk factors compared to 0 risk but the difference was not significant H2O2 level was higher in groups with 3, 2 and 1 risk factors compared to 0 risk group but the difference was not significant. The H2O2 level correlated positively with triglyceride values but not with other MetS risk parameters. There was no significant correlation between DSB and MetS risk parameters.
   Interpretation & conclusions: Our findings showed a cumulative and synergistic effect of the risk factors of MetS on DSB. Individuals with three risk parameters had a greater effect on DNA damage than in those with two or one risk parameter. Although plasma H2O2 level increased with an increase in the fat depots, use of H2O2 to depict OS in MetS should he coupled with an adjunct and estimation of DSB in peripheral blood lymphocytes may be used as indicator of OS in MetS patients.
C1 [Bhutia, Rinchen Doma; Sherpa, Mingma Lhamu; Singh, T. A.] Sikkim Manipal Inst Med Sci, Dept Biochem, Gangtok, India.
   [Khandelwal, Bidita] Sikkim Manipal Inst Med Sci, Dept Med, Gangtok, India.
C3 Sikkim Manipal University; Sikkim Manipal University
RP Bhutia, RD (corresponding author), Sikkim Manipal Inst Med Sci, Dept Biochem, 5th Mile, Tadong 737102, Gangtok, India.
EM nehcnir@yahoo.co.in
RI khandelwal, bidita/K-4935-2012; Bhutia, Rinchen/AAE-6172-2021; Sherpa,
   Mingma/ABB-7061-2021
OI Bhutia, Rinchen Doma/0000-0001-8463-2854; Sherpa, Mingma
   L/0000-0002-5905-6127
FU Indian Council of Medical Research, New Delhi, undertaken in the
   department of Biochemistry [IEC/192/12-05(a), 5/7/1099/2013-RCH]; IL
   Biotech Hub Project North Eastern Region-Biotechnology Programme
   Management Cell, Department of Biotechnology, India
FX This study was a part of our research project [IEC/192/12-05(a)] on
   'Metabolic Syndrome' (5/7/1099/2013-RCH) that was supported by the
   Indian Council of Medical Research, New Delhi, undertaken in the
   department of Biochemistry. Instruments utilized for the project were
   funded by the IL Biotech Hub Project North Eastern Region-Biotechnology
   Programme Management Cell, Department of Biotechnology, India.
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NR 31
TC 3
Z9 4
U1 0
U2 6
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, 400059, INDIA
SN 0971-5916
J9 INDIAN J MED RES
JI Indian J. Med. Res.
PD OCT
PY 2018
VL 148
IS 4
BP 435
EP 440
DI 10.4103/ijmr.IJMR_620_17
PG 6
WC Immunology; Medicine, General & Internal; Medicine, Research &
   Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; General & Internal Medicine; Research & Experimental
   Medicine
GA HI4QS
UT WOS:000456435900011
PM 30666006
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Adler, G
   Skonieczna-Zydecka, K
   Madlani, A
   Ogonowski, J
   Grochans, E
   Pierzak-Sominka, J
   Brodowski, J
   Karakiewicz, B
AF Adler, Grazyna
   Skonieczna-Zydecka, Karolina
   Madlani, Agnieszka
   Ogonowski, Jaroslaw
   Grochans, Elzbieta
   Pierzak-Sominka, Joanna
   Brodowski, Jacek
   Karakiewicz, Beata
TI Association between depression, parameters of adiposity and genetic
   polymorphisms of pro-inflammatory cytokines: IL-1α, IL-1β,
   IL-2 and IL-6 in subjects over 55 years old
SO ACTA BIOCHIMICA POLONICA
LA English
DT Article
DE cross sectional study; genetic variants of cytokines; obesity;
   depression
ID BODY-MASS INDEX; C-REACTIVE PROTEIN; MAJOR DEPRESSION; METABOLIC
   SYNDROME; SERUM-LEVELS; OBESITY; FAT; ADULTS; INTERLEUKIN-1-BETA;
   METAANALYSIS
AB During the last few decades, adiposity has become a relatively common phenomenon worldwide. The available data on the effects of pro-inflammatory factors in both depression and adiposity has been attracting great attention. Aim. We sought to assess the prevalence of -889C> T IL-1 alpha, -31T> C and -511C> T IL-1 beta, -330T> G IL-2 and -174G> C IL-6 genes and their association with adiposity and depression in Polish subjects. Methods. A cohort study was conducted in 2013/2014, covering a sample of 297 individuals (217 female and 80 male). Anthropometric data was handled using the BIA analysis method, while for genotyping PCR-RFLP techniques were used. Results. A positive correlation between depression and anthropometric parameters: adipose tissue (in kg) and adipose tissue (in %) (R= 0.135 and p= 0.02, R= 0.114 and p< 0.05, respectively) was found. No association between studied polymorphisms and depression was observed. Conclusion. Although it was not possible to demonstrate any influence of the studied polymorphisms as the genetic modulator of depression, authors believe that the presented data are noticeable and may provide the basis for future studies on larger groups.
C1 [Adler, Grazyna; Skonieczna-Zydecka, Karolina; Madlani, Agnieszka] Pomeranian Med Univ, Dept Gerontobiol, Szczecin, Poland.
   [Ogonowski, Jaroslaw] Pomeranian Med Univ, Dept Civilizat Dis, Szczecin, Poland.
   [Grochans, Elzbieta] Pomeranian Med Univ, Dept Nursing, Szczecin, Poland.
   [Pierzak-Sominka, Joanna] Pomeranian Med Univ, Dept Publ Hlth, Szczecin, Poland.
   [Brodowski, Jacek] Pomeranian Med Univ, Lab Primary Hlth Care, Szczecin, Poland.
   [Karakiewicz, Beata] Pomeranian Med Univ, Chair & Dept Publ Hlth, Szczecin, Poland.
C3 Pomeranian Medical University; Pomeranian Medical University; Pomeranian
   Medical University; Pomeranian Medical University; Pomeranian Medical
   University; Pomeranian Medical University
RP Adler, G (corresponding author), Pomeranian Med Univ, Dept Gerontobiol, Szczecin, Poland.
EM gra2@op.pl
RI Pierzak-Sominka, Joanna/A-7956-2015; Adler, Grażyna/O-7928-2014;
   Grochans, Elżbieta/K-8659-2014; Skonieczna-Zydecka,
   Karolina/K-7252-2014; Karakiewicz, Beata/N-2083-2014; Grochans,
   Elzbieta/M-1593-2014; Brodowski, Jacek/A-5916-2015
OI Skonieczna-Zydecka, Karolina/0000-0002-3430-9079; Karakiewicz,
   Beata/0000-0001-6527-7287; Grochans, Elzbieta/0000-0002-3679-7002;
   Brodowski, Jacek/0000-0002-6853-9155
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NR 69
TC 9
Z9 9
U1 0
U2 7
PU ACTA BIOCHIMICA POLONICA
PI WARSAW
PA PASTEURA 3, 02-093 WARSAW, POLAND
SN 0001-527X
EI 1734-154X
J9 ACTA BIOCHIM POL
JI Acta Biochim. Pol.
PY 2016
VL 63
IS 2
BP 253
EP 259
DI 10.18388/abp.2015_1063
PG 7
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA DX9OE
UT WOS:000384724200011
PM 26934083
OA gold
DA 2025-06-11
ER

PT J
AU Gomes, HM
   Silveira, AK
   Gasparotto, J
   Bortolin, RC
   Terra, SR
   Brum, PO
   Gelain, DP
   Moreira, JCF
AF Gomes, Henrique Mautone
   Silveira, Alexandre K.
   Gasparotto, Juciano
   Bortolin, Rafael Calixto
   Terra, Silvia R.
   Brum, Pedro O.
   Gelain, Daniel P.
   Fonseca Moreira, Jose C.
TI Effects of coconut oil long-term supplementation in Wistar rats during
   metabolic syndrome- regulation of metabolic conditions involving glucose
   homeostasis, inflammatory signals, and oxidative stress
SO JOURNAL OF NUTRITIONAL BIOCHEMISTRY
LA English
DT Article
DE Coconut Oil; Metabolic Syndrome; Hepatic Oxidative Stress; Conjugated
   Dienes
ID INSULIN-RESISTANCE; FATTY-ACIDS; FRUCTOSE; OBESITY; LIVER; ADIPOSITY;
   ALBUMIN; MODEL
AB This study was designed to evaluate the long-term effects of Fructose (20%) feeding in rats, simulating metabolic syndrome (MetS), and the effects of coconut oil (C.O.) supplementation when administered in a MetS context. MetS is a cluster of systemic conditions that represent an increased chance of developing cardiovascular diseases and type 2 diabetes in the future. C.O. has been the target of media speculation, and recent studies report inconsistent results. C.O. improved glucose homeostasis and reduced fat accumulation in Fructose-fed rats while decreasing the levels of triglycerides (TGs) in the liver. C.O. supplementation also increased TGs levels and fructosamine in serum during MetS, possibly due to white adipose tissue breakdown and high fructose feeding. Pro-inflammatory cytokines IL-1 beta and TNF-alpha were also increased in rats treated with Fructose and C.O. Oxidative stress marker nitrotyrosine is increased in fructose-fed animals, and C.O. treatment did not prevent this damage. No significant changes were observed in lipoperoxidation marker 4-Hydroxynonenal; however, fructose feeding increased total conjugated dienes and caused conjugated dienes to switch their conformation from cis-trans to trans-trans, which was not prevented by C.O. treatment. Potential benefits of C.O. have been reported with inconsistent results, and indeed we observed some benefits of C.O. supplementation in aiding weight loss, fat accumulation, and improving glucose homeostasis. Nonetheless, we also demonstrated that long-term C.O. supplementation could present some problematic effects with higher risk for individuals suffering MetS, including increased TGs and fructosamine levels and conformational changes in dienes. (c) 2023 Elsevier Inc. All rights reserved.
C1 [Gomes, Henrique Mautone; Silveira, Alexandre K.; Gelain, Daniel P.; Fonseca Moreira, Jose C.] Fed Univ Rio Grande do Sul UFRGS, Inst Basic Hlth Sci, Ctr Oxidat Stress Studies, Dept Biochem, Porto Alegre, RS, Brazil.
   [Gasparotto, Juciano] Fed Univ Alfenas UNIFAL, Inst Biomed Sci, Dept Biochem, Alfenas, MG, Brazil.
   [Bortolin, Rafael Calixto] Univ Costa, Dept Ingn Civil & Ambiental, Barranquilla, Atlantico, Colombia.
   [Terra, Silvia R.] Univ Santa Catarina, Hosp Vet UNISUL, Ave Jose Acacio Moreira 787, Tubarao, SC, Brazil.
   [Brum, Pedro O.] Univ Wien, Dept Microbiol Immunol & Genet, Dr Bohr Gasse 9, A-1030 Vienna, Austria.
   [Gomes, Henrique Mautone] Dept Bioquim, Rua Ramiro Barcelos 2600 Anexo, BR-90035003 Porto Alegre, RS, Brazil.
C3 Universidade Federal do Rio Grande do Sul; Universidade Federal de
   Alfenas; Universidad de la Costa; University of Vienna
RP Gomes, HM (corresponding author), Dept Bioquim, Rua Ramiro Barcelos 2600 Anexo, BR-90035003 Porto Alegre, RS, Brazil.
EM hm.gomes93@gmail.com
RI moreira, jose/AAO-6400-2021; Gomes, Henrique/AAP-2363-2021; Bortolin,
   Rafael/O-2711-2014; Gelain, Daniel/I-5144-2013; Brum,
   Patricia/E-6605-2011; Gasparotto, Juciano/K-3239-2013
OI Ozorio Brum, Pedro/0000-0002-5858-8017; Mautone Gomes,
   Henrique/0000-0001-5976-197X; Gasparotto, Juciano/0000-0003-2545-7288
FU Brazilian research agency Conselho Nacional de Desenvolvimento
   Cientifico e Tecnologico (CNPq) [400437/2013-9, 443514/2014-3,
   401260/2014-3]; Brazilian research agency Fundacao de Amparo a Pesquisa
   do Estado do Rio Grande do Sul (FAPERGS) [2299-2551/14-6]; Brazilian
   research agency Propesq-UFRGS; Brazilian research agency Coordenacao de
   Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
FX This work was supported by funds from the Brazilian research agencies
   Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
   #400437/2013-9, #443514/2014-3 and #401260/2014-3, Fundacao de Amparo a
   Pesquisa do Estado do Rio Grande do Sul (FAPERGS) #2299-2551/14-6,
   Propesq-UFRGS and Coordenacao de Aperfeicoamento de Pessoal de Nivel
   Superior (CAPES) .
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NR 53
TC 5
Z9 5
U1 0
U2 12
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0955-2863
EI 1873-4847
J9 J NUTR BIOCHEM
JI J. Nutr. Biochem.
PD APR
PY 2023
VL 114
AR 109272
DI 10.1016/j.jnutbio.2023.109272
EA FEB 2023
PG 11
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA C9LE7
UT WOS:000965042300001
PM 36681309
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Salazar, J
   Duran, P
   Garrido, B
   Parra, H
   Hernández, M
   Cano, C
   Añez, R
   García-Pacheco, H
   Cubillos, G
   Vasquez, N
   Chacin, M
   Bermúdez, V
AF Salazar, Juan
   Duran, Pablo
   Garrido, Bermary
   Parra, Heliana
   Hernandez, Marlon
   Cano, Climaco
   Anez, Roberto
   Garcia-Pacheco, Henry
   Cubillos, Gabriel
   Vasquez, Neidalis
   Chacin, Maricarmen
   Bermudez, Valmore
TI Weight Regain after Metabolic Surgery: Beyond the Surgical Failure
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Review
DE metabolic surgery; obesity; complications; metabolic syndrome; weight
ID ROUX-EN-Y; TRANSORAL OUTLET REDUCTION; POST-BARIATRIC SURGERY;
   MALADAPTIVE EATING PATTERNS; ARGON PLASMA COAGULATION; GASTRIC BYPASS
   PATIENTS; QUALITY-OF-LIFE; SLEEVE GASTRECTOMY; PHYSICAL-ACTIVITY;
   RISK-FACTORS
AB Patients undergoing metabolic surgery have factors ranging from anatomo-surgical, endocrine metabolic, eating patterns and physical activity, mental health and psychological factors. Some of the latter can explain the possible pathophysiological neuroendocrine, metabolic, and adaptive mechanisms that cause the high prevalence of weight regain in postbariatric patients. Even metabolic surgery has proven to be effective in reducing excess weight in patients with obesity; some of them regain weight after this intervention. In this vein, several studies have been conducted to search factors and mechanisms involved in weight regain, to stablish strategies to manage this complication by combining metabolic surgery with either lifestyle changes, behavioral therapies, pharmacotherapy, endoscopic interventions, or finally, surgical revision. The aim of this revision is to describe certain aspects and mechanisms behind weight regain after metabolic surgery, along with preventive and therapeutic strategies for this complication.
C1 [Salazar, Juan; Duran, Pablo; Garrido, Bermary; Parra, Heliana; Hernandez, Marlon; Cano, Climaco] Univ Zulia, Endocrine & Metab Dis Res Ctr, Sch Med, Maracaibo 4004, Venezuela.
   [Anez, Roberto] Hosp Quironsalud, Dept Endocrinol & Nutr, Madrid 28009, Spain.
   [Garcia-Pacheco, Henry] Univ Zulia, Hosp Gen Sur, Fac Med, Dept Cirugia, Maracaibo 4004, Venezuela.
   [Garcia-Pacheco, Henry] Unidad Cirugia Obes & Metab UCOM, Maracaibo 4004, Venezuela.
   [Cubillos, Gabriel; Vasquez, Neidalis] Clin Obes & Envejecimiento SAS, Bogota 110111, Colombia.
   [Chacin, Maricarmen; Bermudez, Valmore] Univ Simon Bolivar, Fac Ciencias Salud, Barranquilla 080001, Colombia.
   [Chacin, Maricarmen; Bermudez, Valmore] Univ Simon Bolivar, Ctr Invest Ciencias Vida, Barranquilla 080001, Colombia.
C3 quironsalud Group
RP Salazar, J (corresponding author), Univ Zulia, Endocrine & Metab Dis Res Ctr, Sch Med, Maracaibo 4004, Venezuela.; Bermúdez, V (corresponding author), Univ Simon Bolivar, Fac Ciencias Salud, Barranquilla 080001, Colombia.; Bermúdez, V (corresponding author), Univ Simon Bolivar, Ctr Invest Ciencias Vida, Barranquilla 080001, Colombia.
EM jjsv18@gmail.com
RI Duran, Pablo/AAW-6866-2020; Bermudez, Valmore/HLH-6291-2023; Bermudez,
   Valmore/E-3517-2018
OI Vasquez Batiz, Neidalis Mirlet/0000-0003-0182-9614; Parra,
   Heliana/0000-0002-6604-4212; Bermudez, Valmore/0000-0003-1880-8887;
   Garrido, Bermary/0000-0002-5522-7697; Hernandez,
   Marlon/0000-0001-9902-7438; Cubillos, Gabriel/0000-0001-6765-4891;
   Duran, Pablo/0000-0002-8030-1780
FU Universidad Simon Bolvar. Vicerrectora de Investigacin
FX No Statement Available
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NR 209
TC 2
Z9 2
U1 0
U2 1
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD FEB
PY 2024
VL 13
IS 4
AR 1143
DI 10.3390/jcm13041143
PG 22
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA JH2S5
UT WOS:001172214400001
PM 38398456
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Iafusco, D
   Franceschi, R
   Maguolo, A
   Nuzio, SG
   Crinò, A
   Delvecchio, M
   Iughetti, L
   Maffeis, C
   Calcaterra, V
   Manco, M
AF Iafusco, Dario
   Franceschi, Roberto
   Maguolo, Alice
   Nuzio, Salvatore Guercio
   Crino, Antonino
   Delvecchio, Maurizio
   Iughetti, Lorenzo
   Maffeis, Claudio
   Calcaterra, Valeria
   Manco, Melania
TI From Metabolic Syndrome to Type 2 Diabetes in Youth
SO CHILDREN-BASEL
LA English
DT Review
DE adolescents; insulin resistance; insulin secretion; youth; metabolic
   syndrome; obesity; oxidative stress; type 2 diabetes
ID IMPAIRED GLUCOSE-TOLERANCE; INSULIN-RESISTANCE; OXIDATIVE STRESS;
   NORMAL-WEIGHT; POSITION STATEMENT; FATTY-ACIDS; CHILDREN; OBESITY; RISK;
   ADOLESCENTS
AB In the frame of metabolic syndrome, type 2 diabetes emerges along a continuum of the risk from the clustering of all its components, namely visceral obesity, high blood pressure and lipids, and impaired glucose homeostasis. Insulin resistance is the hallmark common to all the components and, in theory, is a reversible condition. Nevertheless, the load that this condition can exert on the beta-cell function at the pubertal transition is such as to determine its rapid and irreversible deterioration leading to plain diabetes. The aim of this review is to highlight, in the context of metabolic syndrome, age-specific risk factors that lead to type 2 diabetes onset in youth; resume age specific screening and diagnostic criteria; and anticipate potential for treatment. Visceral obesity and altered lipid metabolism are robust grounds for the development of the disease. Genetic differences in susceptibility to hampered beta-cell function in the setting of obesity and insulin resistance largely explain why some adolescents with obesity do develop diabetes at a young age and some others do not. Lifestyle intervention with a healthy diet and physical activity remains the pillar of the type 2 diabetes treatment in youth. As to the pharmacological management, metformin and insulin have failed to rescue beta-cell function and to ensure long-lasting glycemic control in youth. A new era might start with the approval for use in pediatric age of drugs largely prescribed in adults, such as dipeptidyl peptidase-4 and sodium-dependent glucose transport inhibitors, and of new weight-lowering drugs in the pipeline such as single and multiple agonists of the glucagon-like peptide 1 receptor. The latter drugs can have tremendous impact on the natural history of the disease. By treating diabetes, they will reduce the burden of all the metabolic abnormalities belonging to the syndrome while causing a tremendous weight loss hitherto never seen before.
C1 [Iafusco, Dario] Univ Campania L Vanvitelli, Reg Ctr Pediat Diabet, Dept Woman Child & Gen & Specialist Surg, I-80131 Naples, Italy.
   [Franceschi, Roberto] S Chiara Hosp Trento, Pediat Dept, APSS, I-38122 Trento, Italy.
   [Maguolo, Alice; Maffeis, Claudio] Univ Verona, Dept Surg Dent Pediat & Gynecol, Sect Pediat Diabet & Metab, I-37129 Verona, Italy.
   [Nuzio, Salvatore Guercio] S Maria della Speranza Hosp Battipaglia, Dept Womens & Childrens Hlth, Pediat Unit, I-84091 Salerno, Italy.
   [Crino, Antonino] Fdn Policlin Univ Agostino Gemelli IRCCS, Ctr Rare Dis & Congenital Defects, I-00168 Rome, Italy.
   [Delvecchio, Maurizio] AOU Policlin Bari, Giovanni XXIII Childrens Hosp, Metab Disorders & Diabet Unit, I-70124 Bari, Italy.
   [Iughetti, Lorenzo] Univ Modena & Reggio Emilia, Post Grad Sch Pediat, Dept Med & Surg Sci Mothers Children & Adults, I-41121 Modena, Italy.
   [Calcaterra, Valeria] Univ Pavia, Dept Internal Med, I-27100 Pavia, Italy.
   [Calcaterra, Valeria] V Buzzi Childrens Hosp, Pediat Dept, I-20154 Milan, Italy.
   [Manco, Melania] IRCCS, Bambino Gesu Childrens Hosp, Prevent & Predict Med Unit, I-00165 Rome, Italy.
C3 Universita della Campania Vanvitelli; University of Verona; Catholic
   University of the Sacred Heart; IRCCS Policlinico Gemelli; Universita di
   Modena e Reggio Emilia; University of Pavia; IRCCS Bambino Gesu
RP Manco, M (corresponding author), IRCCS, Bambino Gesu Childrens Hosp, Prevent & Predict Med Unit, I-00165 Rome, Italy.
EM melania.manco@opbg.net
RI Franceschi, Roberto/GRR-6210-2022; Maffeis, Claudio/AAG-5347-2020;
   Calcaterra, Valeria/AAB-7563-2022; Manco, Melania/M-1058-2013; Iughetti,
   Lorenzo/I-4602-2014; Delvecchio, Maurizio/K-8762-2012; maguolo,
   alice/HHS-0886-2022
OI Manco, Melania/0000-0002-6581-975X; CALCATERRA,
   VALERIA/0000-0002-2137-5974; Franceschi, Roberto/0000-0002-2230-7148;
   Iughetti, Lorenzo/0000-0003-0370-7872; Delvecchio,
   Maurizio/0000-0002-1528-0012; maguolo, alice/0000-0002-8921-2012;
   Maffeis, Claudio/0000-0002-3563-4404
FU Italian Ministry of Health [EU_PNRR M6C2]
FX M.M. received funds from the Italian Ministry of Health ("ricerca 5 x
   mille 2023", "ricerca corrente"; and "EU-Next Generation EU_PNRR M6C2-
   Investimento 2.1 Valorizzazione e potenziamento della ricerca biomedica
   del SSN").
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NR 113
TC 7
Z9 7
U1 0
U2 6
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2227-9067
J9 CHILDREN-BASEL
JI Children-Basel
PD MAR
PY 2023
VL 10
IS 3
AR 516
DI 10.3390/children10030516
PG 20
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA C0TQ7
UT WOS:000959152000001
PM 36980074
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Rezazadeh, K
   Aliashrafi, S
   Asghari-Jafarabadi, M
   Ebrahimi-Mameghani, M
AF Rezazadeh, Khatereh
   Aliashrafi, Soodabeh
   Asghari-Jafarabadi, Mohammad
   Ebrahimi-Mameghani, Mehrangiz
TI Antioxidant response to artichoke leaf extract supplementation in
   metabolic syndrome: A double-blind placebo-controlled randomized
   clinical trial
SO CLINICAL NUTRITION
LA English
DT Article
DE Artichoke leaf extract; Metabolic syndrome; Oxidative status; Oxidized
   low-density lipoprotein; Clinical trial
ID CYNARA-SCOLYMUS L.; LOW-DENSITY-LIPOPROTEIN; OXIDATIVE STRESS;
   PROTECTIVE PROPERTIES; PLASMA-CHOLESTEROL; IN-VITRO; DYSPEPSIA;
   ATHEROSCLEROSIS; HEALTH; LEAVES
AB Background: Oxidative stress is associated with most components and complications of Metabolic Syndrome (MetS). Artichoke Leaf Extract (ALE) has demonstrated anti-oxidant properties in both laboratory and animal studies. Aim: This study was designed to examine the effects of ALE on oxidative stress indices in patients with MetS.
   Methods: In the current double-blind placebo-controlled randomized clinical trial, 80 patients with MetS were randomly allocated to either "ALE group" (received 1800 mg ALE as four tablets per day) or "Placebo group" (received placebo containing cornstarch, lactose and avicel as four tablets per day) for 12 weeks. Serum levels of malondialdehyde (MDA), total antioxidant capacity (TAC), oxidized-LDL (ox-LDL), red blood cell glutathione peroxidase (GPx) and superoxidase dismutase (SOD), as well as dietary intakes were assessed at baseline and at the end of the study.
   Results: A total number of 68 patients completed the study (ALE group = 33; placebo group = 35). Dietary intakes of energy, macronutrients, and micronutrients were not significantly different between two groups throughout the trial, with the exception of zinc (p < 0.05). The concentration of ox-LDL decreased significantly in ALE group in comparison to the placebo group (-266.8 +/- 615.9 vs -129.5 +/- 591.2 ng/L; p < 0.05). However, no significant inter- and intra-group changes in MDA, SOD, GPx, and TAC concentrations were observed.
   Conclusion: ALE decreased serum ox-LDL level in patients with MetS, with no beneficial effects on other antioxidant indices.
   Clinical trial registration number: IRC1201409033320N9. (C) 2017 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.
C1 [Rezazadeh, Khatereh] Tabriz Univ Med Sci, Sch Nutr & Food Sci, Talented Students Ctr, Student Res Comm, Tabriz, Iran.
   [Aliashrafi, Soodabeh] Tabriz Univ Med Sci, Sch Nutr & Food Sci, Student Res Comm, Tabriz, Iran.
   [Asghari-Jafarabadi, Mohammad] Tabriz Univ Med Sci, Rd Traff Injury Res Ctr, Tabriz, Iran.
   [Asghari-Jafarabadi, Mohammad] Tabriz Univ Med Sci, Sch Hlth, Dept Stat & Epidemiol, Tabriz, Iran.
   [Ebrahimi-Mameghani, Mehrangiz] Tabriz Univ Med Sci, Sch Nutr & Food Sci, Nutr Res Ctr, Attar Neyshaboori Av,Golghasht St, Tabriz, Iran.
C3 Tabriz University of Medical Science; Tabriz University of Medical
   Science; Tabriz University of Medical Science; Tabriz University of
   Medical Science; Tabriz University of Medical Science
RP Ebrahimi-Mameghani, M (corresponding author), Tabriz Univ Med Sci, Sch Nutr & Food Sci, Nutr Res Ctr, Attar Neyshaboori Av,Golghasht St, Tabriz, Iran.
EM ebrahimimamagani@tbzmed.ac.ir
RI Rezazadeh, Khatereh/N-2488-2019; Aliashrafi, Soodabeh/AAA-1337-2020;
   Asghari Jafarabadi, Mohammmad/A-7478-2017
OI Asghari Jafarabadi, Mohammmad/0000-0003-3284-9749; rezazadeh,
   khatereh/0000-0002-9270-7788
FU Tabriz University of Medical Sciences, Tabriz, Iran [5/97/4653]
FX The authors would like to thank the subjects who participated in this
   study and Dineh pharm. Co. for collaboration in preparation of Artichoke
   Leaf Extract and placebo tablets. Moreover, we kindly acknowledge Danesh
   Pathobiology Laboratory, Khoy, Iran for their assistance in biochemical
   assays. This study was supported by the Research Vice Chancellor, Tabriz
   University of Medical Sciences, Tabriz, Iran (grant number: 5/97/4653).
   The results of this article are derived from the Ph.D. thesis of
   khatereh Rezazadeh (NO, D/41).
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PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0261-5614
EI 1532-1983
J9 CLIN NUTR
JI Clin. Nutr.
PD JUN
PY 2018
VL 37
IS 3
BP 790
EP 796
DI 10.1016/j.clnu.2017.03.017
PG 7
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA GG7LN
UT WOS:000432879800004
PM 28410922
DA 2025-06-11
ER

PT J
AU Ayers, K
   Byrne, LM
   DeMatteo, A
   Brown, NJ
AF Ayers, Katie
   Byrne, Loretta M.
   DeMatteo, Anthony
   Brown, Nancy J.
TI Differential Effects of Nebivolol and Metoprolol on Insulin Sensitivity
   and Plasminogen Activator Inhibitor in the Metabolic Syndrome
SO HYPERTENSION
LA English
DT Article
DE clinical science; insulin resistance; hypertension; cardiovascular
   pathophysiology; antihypertensive therapy
ID 3RD-GENERATION BETA-BLOCKER; TYPE-2 DIABETES-MELLITUS; OXIDATIVE STRESS;
   ENDOTHELIAL FUNCTION; FOREARM VASCULATURE; CARVEDILOL; HYPERTENSION;
   MORTALITY; ATENOLOL; EXPRESSION
AB Early-generation beta-blockers lower blood pressure and reduce cardiovascular morality in coronary artery disease and congestive heart failure but worsen glucose homeostasis and fibrinolytic balance. Nebivolol is a third-generation beta-blocker that increases the bioavailability of nitric oxide. We compared the effect of nebivolol (5 mg/d) and the beta(1)-selective antagonist metoprolol (100 mg/d) on glucose homeostasis and markers of fibrinolysis in 46 subjects with metabolic syndrome. Subjects underwent a frequently sampled IV glucose tolerance test after 3-week washout and placebo treatment and after randomized treatment with study drug. After 12-week treatment, nebivolol and metoprolol equivalently decreased systolic blood pressure, diastolic blood pressure, and heart rate. Neither drug affected beta-cell function, disposition index, or acute insulin response to glucose. Metoprolol significantly decreased the insulin sensitivity index. In contrast, nebivolol did not affect insulin sensitivity, and the decrease in sensitivity was significantly greater after metoprolol than after nebivolol (-1.5 +/- 2.5x10(-4) x min(-1) per milliunit per liter versus 0.04 +/- 2.19x10(-4) x min(-1) per milliunit per liter after nebivolol; P=0.03). Circulating plasminogen activator inhibitor also increased after treatment with metoprolol (from 9.8 +/- 6.8 to 12.3 +/- 7.8 ng/mL) but not nebivolol (from 10.8 +/- 7.8 to 10.5 +/- 6.2 ng/mL; P=0.05 versus metoprolol). Metoprolol, but not nebivolol, increased F-2-isoprostane concentrations. In summary, treatment with metoprolol decreased insulin sensitivity and increased oxidative stress and the antifibrinolytic plasminogen activator inhibitor 1 in patients with metabolic syndrome, whereas nebivolol lacked detrimental metabolic effects. Large clinical trials are needed to compare effects of nebivolol and the beta(1) receptor antagonist metoprolol on clinical outcomes in patients with hypertension and the metabolic syndrome. (Hypertension. 2012;59:893-898.)
C1 [Ayers, Katie; Byrne, Loretta M.; DeMatteo, Anthony; Brown, Nancy J.] Vanderbilt Univ, Sch Med, Dept Med, Div Clin Pharmacol, Nashville, TN 37232 USA.
C3 Vanderbilt University
RP Brown, NJ (corresponding author), Vanderbilt Univ, Sch Med, Dept Med, Div Clin Pharmacol, D-3100 Med Ctr North, Nashville, TN 37232 USA.
EM Nancy.j.brown@vanderbilt.edu
RI ayers, katie/A-6419-2013; Byrne, Loretta/JGE-0737-2023; Stefanadis,
   Christodoulos/ABH-2232-2020
OI Stefanadis, Christodoulos/0000-0001-5974-6454
FU Forest Laboratories, Inc; National Institutes of Health [HL060906,
   UL1RR024975, T35007383]; Shire HRT
FX This work was funded through a grant from Forest Laboratories, Inc, as
   well as from funding from National Institutes of Health grants HL060906,
   UL1RR024975, and T35007383.N.J.B. consults for Novartis, Merck, and
   Boerhinger-Ingelheim; received research funding from Forest
   Laboratories, Inc; and receives research funding from Shire HRT.
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NR 41
TC 58
Z9 62
U1 0
U2 21
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0194-911X
EI 1524-4563
J9 HYPERTENSION
JI Hypertension
PD APR
PY 2012
VL 59
IS 4
BP 893
EP 898
DI 10.1161/HYPERTENSIONAHA.111.189589
PG 6
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 911KQ
UT WOS:000301716100033
PM 22353614
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Gavia-García, G
   Hernández-Alvarez, D
   Arista-Ugalde, TL
   Aguiñiga-Sánchez, I
   Santiago-Osorio, E
   Mendoza-Núñez, VM
   Rosado-Pérez, J
AF Gavia-Garcia, Graciela
   Hernandez-Alvarez, David
   Arista-Ugalde, Taide Laurita
   Aguiniga-Sanchez, Itzen
   Santiago-Osorio, Edelmiro
   Mendoza-Nunez, Victor Manuel
   Rosado-Perez, Juana
TI The Supplementation of Sechium edule var. nigrum spinosum
   (Chayote) Promotes Nrf2-Mediated Antioxidant Protection in Older Adults
   with Metabolic Syndrome
SO NUTRIENTS
LA English
DT Article
DE Sechium edule; metabolic syndrome; antioxidants; inflammatory markers;
   aging; mRNA
ID NF-KAPPA-B; OXIDATIVE STRESS; NEURODEGENERATIVE DISEASES; CHLOROGENIC
   ACID; IN-VITRO; NRF2; ACTIVATION; EXPRESSION; PATHWAY; INFLAMMATION
AB The aim was to determine the effect of Sechium edule var. nigrum spinosum (chayote) on gene expression related to antioxidant protection mechanisms and the inflammatory process in older adults with metabolic syndrome (MetS). A quasi-experimental study was carried out in a convenience sample of 46 older adults diagnosed with MetS: (i) placebo group (PG; n = 20); (ii) experimental group (EG; n = 26). The clinical, biochemical, anthropometric parameters and SOD, GPx, and CAT enzyme activity, alongside total oxidant status (TOS), total antioxidant status (TAS), oxidative stress index (OSI), cytokines (IL-6, IL-8 and TNF-alpha), and mRNA expression of SOD, GPx, CAT, IL-6, IL-8, TNF-alpha, Nrf2, NFkB p50, and NFkB p65, were measured at baseline and 6 months post-intervention. A statistically significant decrease was observed in TOS (baseline, 28.9 +/- 3.6 vs. post, 23.7 +/- 3.4, p < 0.01) and OSI (baseline, 24.1 +/- 3.8 vs. post, 17.7 +/- 4), as well as an increase in IL-6 (baseline, 10.7 +/- 1.1 vs. post, 12.3 +/- 2, p = 0.03), SOD activity (baseline, 167.1 +/- 11.9 vs. post, 180.6 +/- 7.6, p < 0.05), CAT activity (baseline, 1.0 +/- 0.2 vs. post, 1.3 +/- 0.2, p < 0.01), and TAS (baseline, 1.1 +/- 0.1 vs. post, 1.4 +/- 0.1, p < 0.01) in the EG compared to the PG. Regarding the expression of Nrf2, SOD, and IL-6, the EG showed a significant increase vs. basal levels (47%, 44%, and 43%, respectively). Our findings suggest that Sechium edule supplementation promotes the antioxidant response and decreases oxidative stress via Nrf2.
C1 [Gavia-Garcia, Graciela; Hernandez-Alvarez, David; Arista-Ugalde, Taide Laurita; Mendoza-Nunez, Victor Manuel; Rosado-Perez, Juana] Univ Nacl Autonoma Mexico, FES Zaragoza, Res Unit Gerontol, Mexico City 09230, Mexico.
   [Aguiniga-Sanchez, Itzen; Santiago-Osorio, Edelmiro] Univ Nacl Autonoma Mexico, FES Zaragoza, Hematopoiesis & Leukemia Lab, Res Unit Cell Differentiat & Canc, Mexico City 09230, Mexico.
C3 Universidad Nacional Autonoma de Mexico; Universidad Nacional Autonoma
   de Mexico
RP Mendoza-Núñez, VM; Rosado-Pérez, J (corresponding author), Univ Nacl Autonoma Mexico, FES Zaragoza, Res Unit Gerontol, Mexico City 09230, Mexico.
EM graciela_gavia_garcia@comunidad.unam.mx; hereda2912@gmail.com;
   tdlarista@comunidad.unam.mx; itzen.aguiniga@zaragoza.unam.mx;
   edelmiro@unam.mx; mendovic@unam.mx; juanarosadoperez@comunidad.unam.mx
RI Mendoza-Núñez, Víctor Manuel/AFL-2465-2022
OI Mendoza-Nunez, Victor Manuel/0000-0002-9137-3405; Santiago-Osorio,
   Edelmiro/0000-0002-4876-0688
FU National Council of Humanities, Science and Technology (CONAHCyT)
FX We appreciate the support from National Council of Humanities, Science
   and Technology (CONAHCyT) for the scholarship granted to Graciela
   Gavia-Garcia for her postdoctoral position.
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NR 76
TC 0
Z9 0
U1 4
U2 4
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD OCT
PY 2023
VL 15
IS 19
AR 4106
DI 10.3390/nu15194106
PG 15
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA AZ9G5
UT WOS:001122378900001
PM 37836390
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Kuate, D
   Kengne, APN
   Biapa, CPN
   Azantsa, BGK
   Muda, WAMB
AF Kuate, Dieudonne
   Kengne, Anne Pascale Nouemsi
   Biapa, Cabral Prosper Nya
   Azantsa, Boris Gabin Kingue
   Muda, Wan Abdul Manan Bin Wan
TI Tetrapleura tetraptera spice attenuates high-carbohydrate,
   high-fat diet-induced obese and type 2 diabetic rats with metabolic
   syndrome features
SO LIPIDS IN HEALTH AND DISEASE
LA English
DT Article
DE Obesity; Type 2 diabetes; High-carbohydrate high-fat diet; Metabolic
   syndrome; Inflammation; Tetrapleura tetraptera
ID OXIDATIVE STRESS; INSULIN-RESISTANCE; DICHROSTACHYS-GLOMERATA;
   LIPID-METABOLISM; AQUEOUS EXTRACT; DRY FRUIT; HYPERGLYCEMIA;
   INFLAMMATION; ACID; ISOLIQUIRITIGENIN
AB Background: Tetrapleura tetraptera, a seasoning and nutritive spice is also used in western African folk medicine in the management of wide variety of diseases including diabetes, inflammation and hypertension. Flavonoids and saponins are some abundant secondary metabolic constituents in the fruits of this plant. This study aimed at evaluating the potential therapeutic action of the polyphenol-rich hydroethanolic extract (HET) of this fruit in experimentally induced obese and type 2 diabetic rats (T2DM) with characteristic metabolic syndrome (MetS).
   Methods: MetS was induced in rats by high-carbohydrate, high-fat diet and administration of low-dose streptozotocin. Then different oral doses of HET (200 and 400 mg/kg) were administered to T2DM rats for 28 days. A standard antidiabetic drug, metformin (300 mg/kg), was used for comparison. The body weight, systolic blood pressure, oxidative stress and metabolic parameters were then assessed to evaluate the effect of HET on MetS.
   Results: HET reduced weight gain, fasting blood glucose and plasma insulin levels as well as homeostasis model assessment of insulin resistance (HOMA-IR) and alleviated obesity and T2DM associated oxidative stress and hypertension in rats. Moreover, a significantly hypolipidemic property and an attenuation of liver injury and tissue steatosis was observed after HET administration. HET further demonstrated its anti-inflammation effect via down regulation of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), C-reactive protein (CRP), leptin and an increase in adiponectin. The HET exhibited dose-dependent effects which were comparable to that of metformin.
   Conclusions: The present study thereby demonstrates the anti-insulin resistance, antilipidemic, anti-obesity, hypotensive and anti-inflammatory properties of HET; hence it has the potential to be further developed for the management of MetS such as obesity, T2DM and hypertension.
C1 [Kuate, Dieudonne; Muda, Wan Abdul Manan Bin Wan] Univ Sains Malaysia, Sch Hlth Sci, Program Nutr, Kubang Kerian 16150, Kelantan, Malaysia.
   [Kuate, Dieudonne; Kengne, Anne Pascale Nouemsi; Biapa, Cabral Prosper Nya] Univ Dschang, Fac Sci, Dept Biochem, Dschang, Cameroon.
   [Azantsa, Boris Gabin Kingue] Univ Buea, Fac Sci, Dept Biochem & Mol Biol, Buea, Cameroon.
C3 Universiti Sains Malaysia; Universite de Dschang
RP Kuate, D (corresponding author), Univ Sains Malaysia, Sch Hlth Sci, Program Nutr, Kubang Kerian 16150, Kelantan, Malaysia.
EM kuatedie@msu.edu
RI ; khader, yousef/AAE-9620-2019; Wan Muda, Wan A Manan/H-5475-2016
OI Kengne, Andre Pascal/0000-0002-5183-131X; khader,
   yousef/0000-0002-7830-6857; Wan Muda, Wan A Manan/0000-0003-4241-3869
FU Universiti Sains Malaysia, TWAS (The World Academy of Sciences);
   University of Dschang
FX we are grateful to Universiti Sains Malaysia, TWAS (The World Academy of
   Sciences) and the University of Dschang for supporting this work.
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NR 60
TC 65
Z9 66
U1 0
U2 23
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1476-511X
J9 LIPIDS HEALTH DIS
JI Lipids Health Dis.
PD MAY 24
PY 2015
VL 14
AR 50
DI 10.1186/s12944-015-0051-0
PG 13
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA CJ0PO
UT WOS:000355179300001
PM 26003803
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Kahl, KG
   Schweiger, U
   Pars, K
   Kunikowska, A
   Deuschle, M
   Gutberlet, M
   Lichtinghagen, R
   Bleich, S
   Hüper, K
   Hartung, D
AF Kahl, Kai G.
   Schweiger, Ulrich
   Pars, Kaweh
   Kunikowska, Alicja
   Deuschle, Michael
   Gutberlet, Marcel
   Lichtinghagen, Ralf
   Bleich, Stefan
   Hueper, Katja
   Hartung, Dagmar
TI Adrenal gland volume, intra-abdominal and pericardial adipose tissue in
   major depressive disorder
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE Major depressive disorder; Adrenal gland volume; Ectopic fat
ID CORONARY-HEART-DISEASE; VISCERAL FAT; ATHEROSCLEROSIS MESA; INSULIN
   SENSITIVITY; PREMENOPAUSAL WOMEN; COMPUTED-TOMOGRAPHY; CARDIOVASCULAR
   RISK; METABOLIC SYNDROME; METAANALYSIS; ASSOCIATION
AB Major depressive disorder (MDD) is associated with an increased risk for the development of cardio-metabolic diseases. Increased intra-abdominal (IAT) and pericardial adipose tissue (PAT) have been found in depression, and are discussed as potential mediating factors. IAT and PAT are thought to be the result of a dysregulation of the hypothalamus pituitary adrenal axis (HPAA) with subsequent hypercortisolism. Therefore we examined adrenal gland volume as proxy marker for HPAA activation, and IAT and PAT in depressed patients. Twenty-seven depressed patients and 19 comparison subjects were included in this case-control study. Adrenal gland volume, pericardial, intraabdominal and subcutaneous adipose tissue were measured by magnetic resonance imaging. Further parameters included factors of the metabolic syndrome, fasting cortisol, fasting insulin, and proinflammatory cytokines. Adrenal gland and pericardial adipose tissue volumes, serum concentrations of cortisol and insulin, and serum concentrations tumor necrosis factor-a were increased in depressed patients. Adrenal gland volume was positively correlated with intra-abdominal and pericardial adipose tissue, but not with subcutaneous adipose tissue. Our findings point to the role of HPAA dysregulation and hypercortisolism as potential mediators of IAT and PAT enlargement. Further studies are warranted to examine whether certain subtypes of depression are more prone to cardio-metabolic diseases. (C) 2015 Elsevier Ltd. All rights reserved.
C1 [Kahl, Kai G.; Pars, Kaweh; Kunikowska, Alicja; Bleich, Stefan] Hannover Med Sch MHH, Dept Psychiat Social Psychiat & Psychotherapy, Hannover, Germany.
   [Gutberlet, Marcel; Hueper, Katja; Hartung, Dagmar] MHH, Inst Diagnost & Intervent Radiol, Hannover, Germany.
   [Lichtinghagen, Ralf] MHH, Inst Clin Chem, Hannover, Germany.
   [Schweiger, Ulrich] Univ Lubeck, Dept Psychiat & Psychotherapy, Lubeck, Germany.
   [Deuschle, Michael] Cent Inst Mental Hlth, Dept Psychiat & Psychotherapy, Mannheim, Germany.
C3 Hannover Medical School; Hannover Medical School; Hannover Medical
   School; University of Lubeck; Central Institute of Mental Health
RP Kahl, KG (corresponding author), Hannover Med Sch MHH, Dept Psychiat Social Psychiat & Psychotherapy, Hannover, Germany.
EM kahl.kai@mh-hannover.de
RI Hueper, Katja/J-9566-2016; Gutberlet, Matthias/AAL-2699-2021; Bleich,
   Stefan/ABC-1796-2020
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NR 47
TC 27
Z9 29
U1 0
U2 19
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD AUG
PY 2015
VL 58
BP 1
EP 8
DI 10.1016/j.psyneuen.2015.04.008
PG 8
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA CL1XR
UT WOS:000356738700001
PM 25935636
DA 2025-06-11
ER

PT J
AU de Cordova, PB
   Bradford, MA
   Stone, PW
AF de Cordova, Pamela B.
   Bradford, Michelle A.
   Stone, Patricia W.
TI Increased errors and decreased performance at night: A systematic review
   of the evidence concerning shift work and quality
SO WORK-A JOURNAL OF PREVENTION ASSESSMENT & REHABILITATION
LA English
DT Review
DE After-hours; efficiency; productivity; safety
ID MENTAL-HEALTH STATUS; HOSPITAL NURSES; METABOLIC SYNDROME; SLEEP
   DISORDERS; MEDICAL ERRORS; PATIENT-CARE; INJURIES; ALERTNESS; OUTCOMES;
   FATIGUE
AB BACKGROUND: Shift workers have worse health outcomes than employees who work standard business hours. However, it is unclear how this poorer health shift may be related to employee work productivity.
   OBJECTIVE: The purpose of this systematic review is to assess the relationship between shift work and errors and performance.
   METHODS: Searches of MEDLINE/PubMed, EBSCOhost, and CINAHL were conducted to identify articles that examined the relationship between shift work, errors, quality, productivity, and performance. All articles were assessed for study quality.
   RESULTS: A total of 435 abstracts were screened with 13 meeting inclusion criteria. Eight studies were rated to be of strong, methodological quality. Nine studies demonstrated a positive relationship that night shift workers committed more errors and had decreased performance.
   CONCLUSIONS: Night shift workers have worse health that may contribute to errors and decreased performance in the workplace.
C1 [de Cordova, Pamela B.; Bradford, Michelle A.] Rutgers State Univ, Newark, NJ 07102 USA.
   [Stone, Patricia W.] Columbia Univ, Sch Nursing, Ctr Hlth Policy, New York, NY USA.
C3 Rutgers University System; Rutgers University Newark; Rutgers University
   New Brunswick; Columbia University
RP de Cordova, PB (corresponding author), Rutgers State Univ, Nursing, 180 Univ Ave,Room 244, Newark, NJ 07102 USA.
EM pam.decordova@rutgers.edu
RI de Cordova, Pamela/JXL-7188-2024
OI de Cordova, Pamela/0000-0003-4737-8652
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NR 51
TC 51
Z9 59
U1 0
U2 41
PU IOS PRESS
PI AMSTERDAM
PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS
SN 1051-9815
EI 1875-9270
J9 WORK
JI Work
PY 2016
VL 53
IS 4
BP 825
EP 834
DI 10.3233/WOR-162250
PG 10
WC Public, Environmental & Occupational Health
WE Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA DM6PQ
UT WOS:000376475300013
PM 26890590
DA 2025-06-11
ER

PT J
AU Ari, H
   Kayrak, M
   Gündüz, M
   Kayhan, F
   Kaya, Z
   Kiyici, A
   Uguz, F
AF Ari, Hatem
   Kayrak, Mehmet
   Gunduz, Mehmet
   Kayhan, Fatih
   Kaya, Zeynettin
   Kiyici, Aysel
   Uguz, Faruk
TI Association of paraoxonase-1 activity and major depressive disorder in
   patients with metabolic syndrome
SO INTERNATIONAL JOURNAL OF DIABETES IN DEVELOPING COUNTRIES
LA English
DT Article
DE Metabolic syndrome; Depressive disorder; Paraoxonase-1 activity
ID CORONARY-ARTERY-DISEASE; HIGH-DENSITY-LIPOPROTEIN; HEART-DISEASE;
   OXIDATIVE STRESS; PON1; GENE; POLYMORPHISM; METAANALYSIS; WOMEN; RISK
AB Associations between metabolic syndrome (MS) and major depressive disorder (MDD) are well documented although the underlying biological mechanisms for this relationship are less studied. Paraoxonase (PON1) is a high-density lipoprotein (HDL)-associated enzyme, with demonstrated evidence of strong antioxidant activity. Oxidative stress has been implicated in the pathophysiology of MS and MDD. PON1 activity has been studied to some extent in patients with MS and less in MDD. The aim of this study was to compare serum PON1 activity in patients with MS and MDD, MS without MDD, and normal control groups in the context of the biological mechanism of the association between MS and MDD. In this case-control study, 67 patients with MS and 25 healthy controls from the hospital-university staff were recruited. All patients and healthy controls were assessed by a semi-structured psychiatric interview. Patients with MDD were diagnosed according to the DSM-IV criteria for MDD. Serum PON1 activity was determined with a spectrophotometric method, and the activity was compared between patients with MS and MDD, with MS but without MDD, and control groups. Serum PON1 activity levels were lower in patients with MS and MDD group compared to those in the patients with MS and without MDD group and control group (69.5+/-24.2, 84.3+/-34.6, and 97.1+/-40.8 U/ml, p=0.03, respectively). Post hoc analysis showed that PON1 activity was statically significantly lower in the MS with MDD group than in the control group (p=0.02). Impaired PON1 activity, in the context of enhanced oxidative stress, could be one of the possible underlying biological mechanisms of the MS-MDD association.
C1 [Ari, Hatem] Suleyman Demirel Univ, Sch Med, Dept Cardiol, TR-32200 Isparta, Turkey.
   [Kayrak, Mehmet; Gunduz, Mehmet; Kaya, Zeynettin] Selcuk Univ, Meram Sch Med, Dept Cardiol, Konya, Turkey.
   [Kayhan, Fatih; Uguz, Faruk] Selcuk Univ, Meram Sch Med, Dept Psychiat, Konya, Turkey.
   [Kiyici, Aysel] Selcuk Univ, Meram Sch Med, Dept Biochem, Konya, Turkey.
C3 Suleyman Demirel University; Selcuk University; Selcuk University;
   Selcuk University
RP Ari, H (corresponding author), Suleyman Demirel Univ, Sch Med, Dept Cardiol, TR-32200 Isparta, Turkey.
EM hatem_ari@hotmail.com; mehmetkayrak@yahoo.com; m_gunduz@yahoo.com;
   drkayhan@yahoo.com; zeynettinkaya@yahoo.com; ayselkiyici@gmail.com;
   farukuguz@hotmail.com
RI kaya, zeynettin/AAP-7705-2020
CR [Anonymous], 1999, Definition, Diagnosis and Classification of Diabetes Mellitus and its Complications: Report of a WHO Consultation-Part 1: Diagnosis and Classification of Diabetes Mellitus
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NR 36
TC 1
Z9 1
U1 0
U2 7
PU SPRINGER INDIA
PI NEW DELHI
PA 7TH FLOOR, VIJAYA BUILDING, 17, BARAKHAMBA ROAD, NEW DELHI, 110 001,
   INDIA
SN 0973-3930
EI 1998-3832
J9 INT J DIABETES DEV C
JI Int. Diabetes Dev. Ctries.
PD SEP
PY 2015
VL 35
SU 2
BP S258
EP S263
DI 10.1007/s13410-015-0385-1
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA CY6OP
UT WOS:000366529000029
DA 2025-06-11
ER

PT J
AU Pfeuffer, M
   Fielitz, K
   Laue, C
   Winkler, P
   Rubin, D
   Helwig, U
   Giller, K
   Kammann, J
   Schwedhelm, E
   Böger, RH
   Bub, A
   Bell, D
   Schrezenmeir, J
AF Pfeuffer, Maria
   Fielitz, Kerstin
   Laue, Christiane
   Winkler, Petra
   Rubin, Diana
   Helwig, Ulf
   Giller, Katrin
   Kammann, Julia
   Schwedhelm, Edzard
   Boeger, Rainer H.
   Bub, Achim
   Bell, Doris
   Schrezenmeir, Juergen
TI CLA Does Not Impair Endothelial Function and Decreases Body Weight as
   Compared with Safflower Oil in Overweight and Obese Male Subjects
SO JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION
LA English
DT Article
DE endothelial function; metabolic syndrome; cardiovascular disease; PAT
   index
ID CONJUGATED LINOLEIC-ACID; LOW-DENSITY-LIPOPROTEIN; ACTIVATING-FACTOR
   ACETYLHYDROLASE; TANDEM MASS-SPECTROMETRY; C-REACTIVE PROTEIN; VIRGIN
   OLIVE OIL; OXIDATIVE STRESS; LIPID-PEROXIDATION; METABOLIC SYNDROME; FAT
   MASS
AB Objective: Conjugated linoleic acid (CLA) showed a wide range of beneficial biological effects with relevance for cardiovascular health in animal models and humans. Most human studies used olive oil as a reference. This study assessed the effect of CLA as compared with safflower oil on endothelial function and markers of cardiovascular risk in overweight and obese men. Heated safflower oil and olive oil were given for additional descriptive control.
   Methods: Eighty-five overweight men (aged 45-68 years, body mass index 25-35 kg/m(2)) were randomized to receive 4.5 g/d of the CLA isomeric mixture, safflower oil, heated safflower oil, or olive oil in a 4-week double-blind study. Endothelial function was assessed by peripheral arterial tonometry (PAT) index determination in the fasting and postprandial state (i.e., 4 hours after consumption of a fat- and sucrose-rich meal).
   Results: CLA as compared with safflower oil consumption did not impair fasting or postprandial PAT index but decreased body weight. CLA as compared with safflower oil did not change total, low-density lipoprotein (LDL), or high-density lipoprotein (HDL) cholesterol; triglycerides; insulin sensitivity indices; C-reactive protein; soluble adhesion molecules; oxidized LDL; lipoprotein a (Lp[a]); paraoxonase; or platelet-activating factor acetylhydrolase (PAF-AH) activity, but significantly reduced arylesterase activity and increased concentrations of the F-2-isoprostane 8-iso-prostaglandin F (PGF)(2 alpha).
   Conclusion: CLA did not impair endothelial function. Other parameters associated with metabolic syndrome and oxidative stress were not changed or were slightly improved. Results suggest that CLA does not increase cardiovascular risk. Increased F2-isoprostane concentrations in this context may not indicate increased oxidative stress.
C1 [Pfeuffer, Maria; Fielitz, Kerstin; Rubin, Diana; Helwig, Ulf; Giller, Katrin; Kammann, Julia; Bub, Achim; Schrezenmeir, Juergen] Max Rubner Inst, Dept Physiol & Biochem Nutr, D-76131 Karlsruhe, Germany.
   [Pfeuffer, Maria; Fielitz, Kerstin; Rubin, Diana; Helwig, Ulf; Giller, Katrin; Kammann, Julia; Bub, Achim; Schrezenmeir, Juergen] Max Rubner Inst, Dept Physiol & Biochem Nutr, Kiel, Germany.
   [Fielitz, Kerstin; Laue, Christiane; Winkler, Petra] Tecura GmbH, Clin Res Ctr, Kiel, Germany.
   [Rubin, Diana] Univ Clin Schleswig Holstein, Dept Gen Internal Med, Campus Kiel, Germany.
   [Schwedhelm, Edzard; Boeger, Rainer H.] Univ Med Ctr, Inst Expt & Clin Pharmacol & Toxicol, Hamburg, Germany.
   [Bell, Doris] German Aerosp Ctr, Project Management Agcy, Bonn, Germany.
C3 University of Kiel; Schleswig Holstein University Hospital; University
   of Hamburg; University Medical Center Hamburg-Eppendorf; Helmholtz
   Association; German Aerospace Centre (DLR)
RP Pfeuffer, M (corresponding author), Max Rubner Inst, Dept Physiol & Biochem Nutr, Haid & Neu Str 9, D-76131 Karlsruhe, Germany.
EM maria.pfeuffer@mri.bund.de
RI Giller, Katrin/AAE-6065-2021
OI Giller, Katrin/0000-0002-1276-4548
FU Federal Ministry of Education and Research (BMBF) Germany [AZ
   0312823A/B]; Cognis GmbH Monheim, Germany
FX Source of support: Federal Ministry of Education and Research (BMBF)
   Germany, project grant AZ 0312823A/B: Cognis GmbH Monheim, Germany.
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NR 61
TC 48
Z9 48
U1 0
U2 14
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 0731-5724
EI 1541-1087
J9 J AM COLL NUTR
JI J. Am. Coll. Nutr.
PD FEB
PY 2011
VL 30
IS 1
BP 19
EP 28
DI 10.1080/07315724.2011.10719940
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 791KK
UT WOS:000292663900003
PM 21697535
DA 2025-06-11
ER

PT J
AU Ceja-Galicia, ZA
   Cespedes-Acuña, CLA
   El-Hafidi, M
AF Ceja-Galicia, Zeltzin Alejandra
   Cespedes-Acuna, Carlos Leonardo Armando
   El-Hafidi, Mohammed
TI Protection Strategies Against Palmitic Acid-Induced Lipotoxicity in
   Metabolic Syndrome and Related Diseases
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE antioxidants; lipid droplets; lipotoxicity; metabolic syndrome; obesity;
   oxidative stress; palmitic acid
ID PANCREATIC BETA-CELLS; DE-NOVO LIPOGENESIS; FREE FATTY-ACIDS;
   STEAROYL-COA DESATURASE; INSULIN-SECRETION; SIGNALING PATHWAY; OXIDATIVE
   STRESS; LOW-CARBOHYDRATE; GPR40; LIVER
AB Diets rich in carbohydrate and saturated fat contents, when combined with a sedentary lifestyle, contribute to the development of obesity and metabolic syndrome (MetS), which subsequently increase palmitic acid (PA) levels. At high concentrations, PA induces lipotoxicity through several mechanisms involving endoplasmic reticulum (ER) stress, mitochondrial dysfunction, inflammation and cell death. Nevertheless, there are endogenous strategies to mitigate PA-induced lipotoxicity through its unsaturation and elongation and its channeling and storage in lipid droplets (LDs), which plays a crucial role in sequestering oxidized lipids, thereby reducing oxidative damage to lipid membranes. While extended exposure to PA promotes mitochondrial reactive oxygen species (ROS) generation leading to cell damage, acute exposure of ss-cells to PA increases glucose-stimulated insulin secretion (GSIS), through the activation of free fatty acid receptors (FFARs). Subsequently, the activation of FFARs by exogenous agonists has been suggested as a potential therapeutic strategy to prevent PA-induced lipotoxicity in ss cells. Moreover, some saturated fatty acids, including oleic acid, can counteract the negative impact of PA on cellular health, suggesting a complex interaction between different dietary fats and cellular outcomes. Therefore, the challenge is to prevent the lipid peroxidation of dietary unsaturated fatty acids through the utilization of natural antioxidants. This complexity indicates the necessity for further research into the function of palmitic acid in diverse pathological conditions and to find the main therapeutic target against its lipotoxicity. The aim of this review is, therefore, to examine recent data regarding the mechanism underlying PA-induced lipotoxicity in order to identify strategies that can promote protection mechanisms against lipotoxicity, dysfunction and apoptosis in MetS and obesity.
C1 [Ceja-Galicia, Zeltzin Alejandra; El-Hafidi, Mohammed] Inst Nacl Cardiol Ignacio Chavez, Dept Biomed Cardiovasc, Mexico City 14080, Mexico.
   [Cespedes-Acuna, Carlos Leonardo Armando] Univ Bio Bio, Fac Ciencias, Dept Ciencias Basicas, Ave Andres Bello 720, Chillan 3780708, Chile.
C3 National Institute of Cardiology - Mexico; Universidad del Bio-Bio
RP El-Hafidi, M (corresponding author), Inst Nacl Cardiol Ignacio Chavez, Dept Biomed Cardiovasc, Mexico City 14080, Mexico.
EM alejandra.ceja@cardiologia.org.mx; ccespedes@ubiobio.cl;
   mohammed.elhafidi@cardiologia.org.mx
RI Cespedes-Acuna, Carlos/D-3138-2013
OI Cespedes-Acuna, Carlos/0000-0002-3715-3268; Ceja Galicia, Zeltzin
   Alejandra/0000-0002-0874-1845
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NR 174
TC 4
Z9 4
U1 6
U2 6
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD JAN
PY 2025
VL 26
IS 2
AR 788
DI 10.3390/ijms26020788
PG 23
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA T3U7J
UT WOS:001404304800001
PM 39859502
OA gold
DA 2025-06-11
ER

PT J
AU Najafi, A
   Pourfarzam, M
   Zadhoush, F
AF Najafi, Ali
   Pourfarzam, Morteza
   Zadhoush, Fouzieh
TI Oxidant/antioxidant status in Type-2 diabetes mellitus patients with
   metabolic syndrome
SO JOURNAL OF RESEARCH IN MEDICAL SCIENCES
LA English
DT Article
DE Diabetes mellitus Type 2; metabolic syndrome; oxidative stress;
   sodium-potassium-exchanging ATPase
ID OXIDATIVE STRESS; ENDOTHELIAL DYSFUNCTION; LIPID-PEROXIDATION;
   ASSOCIATION; INFLAMMATION; PREVALENCE; MEMBRANE; GLUCOSE; BLOOD
AB Background: The concurrence of metabolic syndrome (MS) and diabetes mellitus (DM) is increasing worldwide. The long-term complications of these chronic diseases are a threat to patients' well-being. Oxidative stress is involved in the pathogenesis of several diseases. To understand the basic pathophysiological mechanisms of Type-2 DM (T2DM) and its related complications, we aimed to investigate the oxidant/antioxidant status and Na+-K+ ATPase activity in T2DM with MS. Materials and Methods: A population of ninety individuals including fifty patients diagnosed with T2DM and MS, but without overt diabetes complications, and forty individuals without T2DM or MS as control group participated in this study. Plasma malondialdehyde (MDA), catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx) activities, total antioxidant capacity (TAC), and Na+-K+ ATPase activity were assessed by standard laboratory methods. Results: Plasma MDA in patients group was statistically significantly higher than that of controls (P <= 0.05). Whereas, Na+-K+ ATPase activity was statistically significantly lower in patient group (P <= 0.05). TAC, CAT, SOD, and GPx enzyme activities were not statistically significantly different between two groups (P > 0.05). Results from the patient group showed positive correlations between CAT activity and triglyceride and positive correlations between GPx activity and weight, body mass index (BMI), and waist circumference. In addition, there was a positive correlation between MDA results with high-density lipoprotein-cholesterol (HDL-C) and total cholesterol and a negative correlation with TAC, BMI, and weight (P <= 0.05) in controls. Conclusion: Because T2DM patients were without any vascular complications, antioxidant defense results may reflect the lack of progression of diabetes complications in these patients. These results emphasize the need for initial and continued assessment of cardiovascular disease risks in diabetic individuals. Implementation of timely interventions may improve the management of diabetes and prevent the progression of diabetes complications.
C1 [Najafi, Ali; Pourfarzam, Morteza; Zadhoush, Fouzieh] Isfahan Univ Med Sci, Sch Pharm & Pharmaceut Sci, Dept Clin Biochem, Esfahan, Iran.
C3 Isfahan University of Medical Sciences
RP Zadhoush, F (corresponding author), Isfahan Univ Med Sci, Sch Pharm & Pharmaceut Sci, Dept Clin Biochem, Esfahan, Iran.
EM f.zadhoush@pharm.mui.ac.ir
RI zadhoush, fouzieh/S-4976-2018
FU Isfahan University of Medical Sciences [397683]
FX This study was supported by grants from Isfahan University of Medical
   Sciences (grant no. 397683).
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NR 28
TC 9
Z9 10
U1 0
U2 1
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, Maharashtra, INDIA
SN 1735-1995
EI 1735-7136
J9 J RES MED SCI
JI J. Res. Med. Sci.
PD JAN-DEC
PY 2021
VL 26
IS 1
DI 10.4103/jrms.JRMS_249_20
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA QQ6KF
UT WOS:000624631200006
PM 34084185
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Zhou, Y
   Yang, GF
   Peng, W
   Zhang, HL
   Peng, ZY
   Ding, N
   Guo, T
   Cai, YZ
   Deng, QJ
   Chai, XP
AF Zhou, Yang
   Yang, Guifang
   Peng, Wen
   Zhang, Hongliang
   Peng, Zhenyu
   Ding, Ning
   Guo, Tao
   Cai, Yuzhong
   Deng, Qijian
   Chai, Xiangping
TI Relationship between Depression Symptoms and Different Types of Measures
   of Obesity (BMI, SAD) in US Women
SO BEHAVIOURAL NEUROLOGY
LA English
DT Article
ID SAGITTAL ABDOMINAL DIAMETER; BODY-MASS INDEX; METABOLIC SYNDROME;
   RISK-FACTORS; DISORDERS; AGE; ASSOCIATION; COMORBIDITY; PREVALENCE;
   HEALTH
AB Objective. To estimate the relationship between obesity (defined by both BMI and SAD) and various levels of depressive symptoms in women in the United States. Methods. This is a cross-sectional design. All data were collected from NHANES 2011-2012 and 2013-2014. The Patient Health Questionnaire (PHQ-9) was the primary variable used to index depressive symptoms. SAD was assessed using an abdominal caliper. We stratified participates into three groups according to SAD (trisection): T1: low (11.8-18.4 cm), T2: middle (18.5-22.8 cm), and T3: high (22.9-40.1 cm). Other data were collected following the NHANES protocols. We aimed to investigate the effects of obesity on the depression in the NHANES populations. Results. A total of 4477 women were enrolled in the final study population. Participants with a high SAD had the highest risk of clinical depression symptoms (OR=1.2, 95% CI: 1.1-1.4), which was, in particular, the case for moderate-severe depression (OR=1.4, 95% CI: 1.1-1.7) and severe depression (OR=1.4, 95% CI: 1.0-1.9). We also found a significant relationship between SAD and BMI (r=0.836). We did, however, not find a significant relationship between BMI and severe depression. Conclusions. SAD had a better correlation with clinical depression symptoms than BMI, especially regarding severe depression symptoms.
C1 [Zhou, Yang; Yang, Guifang; Peng, Wen; Zhang, Hongliang; Peng, Zhenyu; Ding, Ning; Guo, Tao; Cai, Yuzhong; Chai, Xiangping] Cent South Univ, Xiangya Hosp 2, Dept Emergency Med, Changsha, Peoples R China.
   [Zhou, Yang; Yang, Guifang; Peng, Wen; Zhang, Hongliang; Peng, Zhenyu; Ding, Ning; Guo, Tao; Cai, Yuzhong; Chai, Xiangping] Cent South Univ, Xiangya Hosp 2, Emergency Med & Difficult Dis Inst, Changsha, Peoples R China.
   [Deng, Qijian] Cent South Univ, Xiangya Hosp 2, Dept Psychiat, Changsha, Peoples R China.
C3 Central South University; Central South University; Central South
   University
RP Chai, XP (corresponding author), Cent South Univ, Xiangya Hosp 2, Dept Emergency Med, Changsha, Peoples R China.; Chai, XP (corresponding author), Cent South Univ, Xiangya Hosp 2, Emergency Med & Difficult Dis Inst, Changsha, Peoples R China.; Deng, QJ (corresponding author), Cent South Univ, Xiangya Hosp 2, Dept Psychiat, Changsha, Peoples R China.
EM zhouzhou1107@csu.edu.cn; yangguifang@csu.edu.cn; fenghuaxuepiao@qq.com;
   zhanghongliang@csu.edu.cn; pengzhenyu1999@csu.edu.cn;
   doctordingning@csu.edu.cn; guotao17@csu.edu.cn; 188202152@csu.edu.cn;
   dengqijian@csu.edu.cn; chaixiangping@csu.edu.cn
RI Yang, Gui/KXQ-7081-2024
FU Natural Science Foundation of Hunan Province, China [2019JJ40451];
   National Natural Science Foundation of China [81100221]
FX The authors thank all the participants in NHANES. This work was
   supported by the Natural Science Foundation of Hunan Province, China
   (Grant No. 2019JJ40451) and the National Natural Science Foundation of
   China (Grant No. 81100221).
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NR 36
TC 11
Z9 11
U1 2
U2 17
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0953-4180
EI 1875-8584
J9 BEHAV NEUROL
JI Behav. Neurol.
PD NOV 23
PY 2020
VL 2020
AR 9624106
DI 10.1155/2020/9624106
PG 10
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology
GA PE5GX
UT WOS:000598395200001
PM 33299495
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Perez-Diaz, C
   Uriz-Martínez, M
   Ortega-Rico, C
   Leno-Duran, E
   Barrios-Rodrígueza, R
   Salcedo-Bellido, I
   Arrebola, JP
   Requena, P
AF Perez-Diaz, Celia
   Uriz-Martinez, Maialen
   Ortega-Rico, Carmen
   Leno-Duran, Ester
   Barrios-Rodrigueza, Rocio
   Salcedo-Bellido, Inmaculada
   Arrebola, Juan Pedro
   Requena, Pilar
TI Phthalate exposure and risk of metabolic syndrome components: A
   systematic review
SO ENVIRONMENTAL POLLUTION
LA English
DT Review
DE Phthalate exposure; Human; Metabolic syndrome; Systematic review
ID INSULIN-RESISTANCE; OXIDATIVE STRESS; CRITICAL WINDOWS; BODY-SIZE;
   URINARY CONCENTRATIONS; CHILDRENS HEALTH; BISPHENOL-A; CHILDHOOD;
   ASSOCIATION; OBESITY
AB Metabolic syndrome is a cluster of conditions that increase the risk of cardiovascular disease, i.e. obesity, insulin resistance, hypertriglyceridemia, low high-density lipoprotein cholesterol (HDL-c) levels and arterial hypertension. Phthalates are environmental chemicals which might influence the risk of the aforementioned disturbances, although the evidence is still controversial. The objective of this work was to synthesize the evidence on the association between human phthalate exposure and metabolic syndrome or any of its components. In this systematic review, the PRISMA guidelines were followed and the literature was search in PubMed, Web of Science and Scopus. Longitudinal and cross-sectional studies were included, the later only if a subclinical marker of disease was evaluated. The methodological quality was assessed with the Newcastle Ottawa Scale and a checklist for Analytical Cross-Sectional Studies developed in the Joanna Briggs Institute. A total of 58 articles were identified that showed high heterogenicity in the specific phthalates assessed, time-window of exposure and duration of follow-up. The quality of the studies was evaluated as high (n = 46, score >7 points) or medium (n = 12, score 4-6). The most frequently studied phthalates were DEHP-MEHP, MBzP and MEP. The evidence revealed a positive association between prenatal (in utero) exposure to most phthalates and markers of obesity in the offspring, but contradictory results when postnatal exposure and obesity were assessed. Moreover, postnatal phthalate exposure showed positive and very consistent associations with markers of diabetes and, to a lesser extent, with triglyceride levels. However, fewer evidence and contradictory results were found for HDL-c levels and markers of hypertension. The suggested mechanisms for these metabolic effects include transcription factor PPAR activation, antagonism of thyroid hormone function, antiandrogenic effects, oxidative stress and inflammation, and epigenetic changes. Nevertheless, as the inconsistency of some results could be related to differences in the study design, future research should aim to standardise the exposure assessment.
C1 [Perez-Diaz, Celia; Uriz-Martinez, Maialen; Ortega-Rico, Carmen; Barrios-Rodrigueza, Rocio; Salcedo-Bellido, Inmaculada; Arrebola, Juan Pedro; Requena, Pilar] Univ Granada, Pharm Sch, Dept Prevent Med & Publ Hlth, Campus Cartuja S-N, Granada 18071, Spain.
   [Perez-Diaz, Celia; Barrios-Rodrigueza, Rocio; Salcedo-Bellido, Inmaculada; Arrebola, Juan Pedro; Requena, Pilar] Inst Invest Biosanit Ibs GRANADA, Avda Madrid 15,Pabellon Consultas Externas 2,2 Pla, Granada 18012, Spain.
   [Leno-Duran, Ester] Univ Granada, Med Sch, Dept Obstet & Gynaecol, Parque Tecnol Salud,Ave Invest 11, Granada 18016, Spain.
   [Barrios-Rodrigueza, Rocio; Salcedo-Bellido, Inmaculada; Arrebola, Juan Pedro; Requena, Pilar] Inst Salud Carlos III, Consortium Biomed Res Epidemiol & Publ Hlth CIBERE, C Monforte de Lemos 3-5,Pabellon 11 Planta 0, Madrid 28029, Spain.
   [Leno-Duran, Ester] Fac Med, Dept Obstet & Ginecol, Ave Invest 11, Granada 18016, Spain.
C3 University of Granada; Instituto de Investigacion Biosanitaria IBS
   Granada; University of Granada; Instituto de Salud Carlos III
RP Leno-Duran, E (corresponding author), Fac Med, Dept Obstet & Ginecol, Ave Invest 11, Granada 18016, Spain.
EM esterleno@ugr.es
RI Pérez, Celia/IQV-7001-2023; Requena, Pilar/B-1919-2017; Arrebola,
   Juan/A-5205-2017; Salcedo Bellido, Inmaculada/L-7718-2014
OI Arrebola, Juan P./0000-0002-8643-2423; Ortega-Rico,
   Carmen/0000-0001-8432-662X; Uriz Martinez, Maialen/0000-0001-7491-0777;
   Salcedo Bellido, Inmaculada/0000-0003-4601-198X; , Ester
   Leno-Duran/0000-0001-5697-2819; Perez-Diaz, Celia/0000-0002-6550-1629
FU Instituto de Salud Carlos III [PI20/01568]; Instituto de Salud Carlos
   III, Spain [FI21/00269]
FX <STRONG>This study was supported by research grants from Instituto de
   Salud Carlos III (PI20/01568) . Celia Perez-Diaz is under contract PFIS
   (FI21/</STRONG>00269, Pre-doctoral Helath Research Training Contracts,
   Instituto de Salud Carlos III, Spain).
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NR 129
TC 14
Z9 15
U1 9
U2 25
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 0269-7491
EI 1873-6424
J9 ENVIRON POLLUT
JI Environ. Pollut.
PD JAN 1
PY 2024
VL 340
AR 122714
DI 10.1016/j.envpol.2023.122714
EA NOV 2023
PN 1
PG 20
WC Environmental Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology
GA Z5VO2
UT WOS:001112750500001
PM 37844863
OA Bronze
DA 2025-06-11
ER

PT J
AU Holmannova, D
   Borsky, P
   Andrys, C
   Hamakova, K
   Cermakova, E
   Poctova, G
   Fiala, Z
   Smejkalova, J
   Blaha, V
   Borska, L
AF Holmannova, Drahomira
   Borsky, Pavel
   Andrys, Ctirad
   Hamakova, Kvetoslava
   Cermakova, Eva
   Poctova, Gabriela
   Fiala, Zdenek
   Smejkalova, Jindra
   Blaha, Vladimir
   Borska, Lenka
TI Chromosomal Aberrations and Oxidative Stress in Psoriatic Patients with
   and without Metabolic Syndrome
SO METABOLITES
LA English
DT Article
DE chromosomal aberration; psoriasis; metabolic syndrome
ID DNA-DAMAGE; CARDIOVASCULAR-DISEASE; PLAQUE PSORIASIS; RISK; CANCER; HDL;
   BIOMARKERS; REPAIR
AB Psoriasis and metabolic syndrome (MetS), a common comorbidity of psoriasis, are associated with mild chronic systemic inflammation that increases oxidative stress and causes cell and tissue damage. At the cellular level, chromosomal and DNA damage has been documented, thus confirming their genotoxic effect. The main objective of our study was to show the genotoxic potential of chronic inflammation and determine whether the presence of both pathologies increases chromosomal damage compared to psoriasis alone and to evaluate whether there are correlations between selected parameters and chromosomal aberrations in patients with psoriasis and MetS psoriasis. Clinical examination (PASI score and MetS diagnostics according to National Cholesterol Education Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults; NCE/ATPIII criteria), biochemical analysis of blood samples (fasting glucose, total cholesterol, low density and high density lipoproteins; LDL, HDL, non-HDL, and triglycerides;TAG), DNA/RNA oxidative damage, and chromosomal aberration test were performed in 41 participants (20 patients with psoriasis without MetS and 21 with MetS and psoriasis). Our results showed that patients with psoriasis without metabolic syndrome (nonMetS) and psoriasis and MetS had a higher rate of chromosomal aberrations than the healthy population for which the limit of spontaneous, natural aberration was <2%. No significant differences in the aberration rate were found between the groups. However, a higher aberration rate (higher than 10%) and four numerical aberrations were documented only in the MetS group. We found no correlations between the number of chromosomal aberrations and the parameters tested except for the correlation between aberrations and HDL levels in nonMetS patients (rho 0.44; p < 0.02). Interestingly, in the MetS group, a higher number of chromosomal aberrations was documented in non-smokers compared to smokers. Data from our current study revealed an increased number of chromosomal aberrations in patients with psoriasis and MetS compared to the healthy population, especially in psoriasis with MetS, which could increase the genotoxic effect of inflammation and the risk of genomic instability, thus increasing the risk of carcinogenesis.
C1 [Holmannova, Drahomira; Borsky, Pavel; Poctova, Gabriela; Fiala, Zdenek; Smejkalova, Jindra; Borska, Lenka] Charles Univ Prague, Fac Med Hradec Kralove, Inst Prevent Med, Hradec Kralove 50003, Czech Republic.
   [Andrys, Ctirad] Charles Univ Prague, Fac Med Hradec Kralove, Dept Clin Immunol & Allergol, Hradec Kralove 50003, Czech Republic.
   [Hamakova, Kvetoslava] Univ Hosp Hradec Kralove, Fac Med Hradec Kralove, Clin Dermal & Venereal Dis, Hradec Kralove 50005, Czech Republic.
   [Cermakova, Eva] Charles Univ Prague, Med Fac, Dept Med Biophys, Hradec Kralove 50003, Czech Republic.
   [Blaha, Vladimir] Charles Univ Prague, Med Fac, Dept Internal Med Metab Care & Gerontol 3, Hradec Kralove 50003, Czech Republic.
C3 University Hospital Hradec Kralove; Charles University Prague;
   University Hospital Hradec Kralove; Charles University Prague;
   University Hospital Hradec Kralove; Charles University Prague; Charles
   University Prague; Charles University Prague
RP Borsky, P (corresponding author), Charles Univ Prague, Fac Med Hradec Kralove, Inst Prevent Med, Hradec Kralove 50003, Czech Republic.
EM holmd9ar@lfhk.cuni.cz; borskyp@lfhk.cuni.cz; andrys@lfhk.cuni.cz;
   kveta@hamakova.cz; cermakovae@lfhk.cuni.cz; poctovag@lfhk.cuni.cz;
   fiala@lfhk.cuni.cz; smejkal@lfhk.cuni.cz; blaha@lfhk.cuni.cz;
   borka@lfhk.cuni.cz
RI Holmannova, Drahomira/G-6260-2017; Cermakova, Eva/B-1906-2017; Fiala,
   Zdeněk/E-5962-2017; Borsky, Pavel/S-6307-2016; Blaha,
   Vladimir/C-1151-2016; Borska, Lenka/S-6304-2016
OI Borsky, Pavel/0000-0001-5253-2808; Blaha, Vladimir/0000-0001-8088-9919;
   Holmannova, Drahomira/0000-0002-9865-9991; Borska,
   Lenka/0000-0002-8580-1485
FU Cooperatio Program; Charles University, Faculty of Medicine in Hradec
   Kralove, the Czech Republic [SVV-260543/2020]
FX This work was supported by the Cooperatio Program, research area HEAS
   and by Charles University, Faculty of Medicine in Hradec Kralove, the
   Czech Republic, SVV-260543/2020.
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NR 65
TC 2
Z9 2
U1 0
U2 8
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2218-1989
J9 METABOLITES
JI Metabolites
PD AUG
PY 2022
VL 12
IS 8
AR 688
DI 10.3390/metabo12080688
PG 14
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 4A9LB
UT WOS:000845412000001
PM 35893255
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Akgün, S
   Köken, T
   Kahraman, A
AF Akgun, Sema
   Koken, Tulay
   Kahraman, Ahmet
TI Evaluation of adiponectin and leptin levels and oxidative stress in
   bipolar disorder patients with metabolic syndrome treated by valproic
   acid
SO JOURNAL OF PSYCHOPHARMACOLOGY
LA English
DT Article
DE Bipolar disorder; valproic acid; metabolic syndrome; adipokines;
   oxidative stress
ID ADIPOSE-TISSUE; BODY-WEIGHT; EPILEPTIC CHILDREN; INSULIN-RESISTANCE;
   PLASMA LEPTIN; SERUM LEPTIN; OBESITY; PROTEIN; GAIN; OVERWEIGHT
AB Introduction: An increased risk for metabolic syndrome (MS) has been described for people with psychotic and mood disorders. The aim of this study was to determine the influence of valproic acid (VPA) treatment on adiponectin, leptin levels and oxidative stress in bipolar disorder (BD).
   Methods: Forty patients with BD receiving VPA monotherapy and 20 healthy control subjects were included in this study. BD patients were divided into two groups with and without MS as group 1 and group 2, respectively. Twenty BD patients diagnosed according to the Diagnostic and Statistical Manual for Mental Disorders (DSM IV) were assessed for MS according to the National Cholesterol Education Program (NCEP) Adult Treatment Panel (ATP III) criteria. Adiponectin, leptin, protein carbonyls, sulfhydryl (-SH) and malondialdehyde (MDA) levels were measured in 40 BD patients and 20 control subjects.
   Results: Serum adiponectin levels were significantly lower in group 1 patients than in group 2 and control subjects (p<.001). Serum leptin levels were significantly higher in group 1 patients than in group 2 and control subjects (p<.001). Serum -SH levels were significantly lower in group 2 patients than in group 1 (p<.001) and control subjects (p<.05). Serum carbonyl levels were significantly higher in group 1 and group 2 patients than in control subjects (p<.001). Serum MDA levels were significantly higher in group 1 patients than in group 2 and control subjects (p<.001).
   Conclusion: These results provide further evidence that VPA treatment for patients with BD contributed to the metabolic disturbances, such as the decreased serum adiponectin and -SH levels, as well as the increased serum leptin, MDA and carbonyl levels.
C1 [Akgun, Sema; Koken, Tulay; Kahraman, Ahmet] Afyon Kocatepe Univ, Dept Med Biochem, Fac Med, TR-03200 Afyon, Turkey.
C3 Afyon Kocatepe University
RP Kahraman, A (corresponding author), Afyon Kocatepe Univ, Dept Med Biochem, Fac Med, TR-03200 Afyon, Turkey.
EM ahmetkah@aku.edu.tr
RI Kahraman, Ahmet/JDD-5660-2023
OI Kahraman, Ahmet/0000-0003-3310-3252
FU Afyon Kocatepe University [07.Tip.13]
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: This study
   was supported by the Scientific Investigation Fund Project of Afyon
   Kocatepe University (07.Tip.13).
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NR 42
TC 10
Z9 11
U1 0
U2 7
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0269-8811
EI 1461-7285
J9 J PSYCHOPHARMACOL
JI J. Psychopharmacol.
PD NOV
PY 2017
VL 31
IS 11
SI SI
BP 1453
EP 1459
DI 10.1177/0269881117715608
PG 7
WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA FN5BP
UT WOS:000416021800007
PM 28875764
DA 2025-06-11
ER

PT J
AU Akbaraly, TN
   Ancelin, ML
   Jaussent, I
   Ritchie, C
   Barberger-Gateau, P
   Dufouil, C
   Kivimaki, M
   Berr, C
   Ritchie, K
AF Akbaraly, Tasnime N.
   Ancelin, Marie-Laure
   Jaussent, Isabelle
   Ritchie, Craig
   Barberger-Gateau, Pascale
   Dufouil, Carole
   Kivimaki, Mika
   Berr, Claudine
   Ritchie, Karen
TI Metabolic Syndrome and Onset of Depressive Symptoms in the Elderly
   Findings from the Three-City Study
SO DIABETES CARE
LA English
DT Article
ID LATE-LIFE; HEALTH; RISK; ASSOCIATION; POPULATION; MORTALITY; DISEASE;
   GENDER; ADULTS; WOMEN
AB OBJECTIVE-Given the increasing prevalence of both metabolic syndrome (MetS) and depressive symptoms during old age, we aimed to examine prospectively the association between MetS and the onset of depressive symptoms according to different age-groups in a large, general elderly population.
   RESEARCH DESIGN AND METHODS-This was a prospective cohort study of 4,446 men and women aged 65-91 years who were free of depression or depressive symptoms at baseline (the Three-City Study, France). MetS was defined using the National Cholesterol Education Program Adult Treatment Panel III criteria. New onset of depressive symptoms (the Center for Epidemiologic Studies Depression Scale score >= 16 and use of antidepressant treatment) was assessed at 2- and 4-year follow-ups.
   RESULTS-After adjusting for a large range of potential confounders, we observed MetS to be associated with 1.73-fold (95% CI 1.02-2.95) odds for new-onset depressive symptoms in the youngest age-group (65-70 years at baseline), independently of cardiovascular diseases. No such association was seen in older age-groups.
   CONCLUSIONS-Our findings suggest that the link between MetS and depressive symptoms evidenced until now in middle-aged people can be extended to older adults but not to the oldest ones. Additional research is needed to examine if a better management of MetS prevents depressive symptoms in people aged 65-70 years. Diabetes Care 34:904-909, 2011
C1 [Akbaraly, Tasnime N.; Ancelin, Marie-Laure; Jaussent, Isabelle; Berr, Claudine; Ritchie, Karen] INSERM, U1061, F-34000 Montpellier, France.
   [Akbaraly, Tasnime N.; Ancelin, Marie-Laure; Jaussent, Isabelle; Berr, Claudine; Ritchie, Karen] Univ Montpellier I, Montpellier, France.
   [Akbaraly, Tasnime N.; Kivimaki, Mika] UCL, Dept Epidemiol & Publ Hlth, London, England.
   [Akbaraly, Tasnime N.; Berr, Claudine] Ctr Hosp Univ Montpellier, Ctr Memoire Ressource & Rech, F-34059 Montpellier, France.
   [Ritchie, Craig; Ritchie, Karen] Univ London Imperial Coll Sci Technol & Med, Fac Med, London, England.
   [Barberger-Gateau, Pascale] INSERM, U897, Bordeaux, France.
   [Barberger-Gateau, Pascale] Univ Bordeaux 2, F-33076 Bordeaux, France.
   [Dufouil, Carole] INSERM, U708, Paris, France.
   [Dufouil, Carole] Hop La Pitie Salpetriere, Paris, France.
C3 Institut National de la Sante et de la Recherche Medicale (Inserm);
   Universite de Montpellier; Universite de Montpellier; University of
   London; University College London; Universite de Montpellier; CHU de
   Montpellier; Imperial College London; Institut National de la Sante et
   de la Recherche Medicale (Inserm); Universite de Bordeaux; Universite de
   Bordeaux; Institut National de la Sante et de la Recherche Medicale
   (Inserm); Sorbonne Universite; Assistance Publique Hopitaux Paris
   (APHP); Hopital Universitaire Pitie-Salpetriere - APHP
RP Akbaraly, TN (corresponding author), INSERM, U1061, F-34000 Montpellier, France.
EM tasnime.akbaraly@inserm.fr
RI Kivimaki, Mika/B-3607-2012; Dufouil, Carole/F-5751-2014; Berr,
   Claudine/D-5238-2014; Akbaraly, Tasnime/H-1389-2018; Ancelin,
   Marie-Laure/L-1198-2019; Ritchie, Karen/G-3571-2013
OI Jaussent, Isabelle/0000-0002-8205-7590; Kivimaki,
   Mika/0000-0002-4699-5627; Berr, Claudine/0000-0001-5254-7655; Akbaraly,
   Tasnime/0000-0002-2150-4190; Ancelin, Marie-Laure/0000-0002-1149-4320;
   Ritchie, Karen/0000-0002-0688-8982
FU Fondation pour la Recherche Medicate; Caisse Nationale Maladie des
   Travailleurs Salaries; Direction Generale de la Sante; MGEN; Institut de
   la Longevite; Conseils Regionaux d'Aquitaine et Bourgogne; Fondation de
   France; Ministry of Research Institut National de la Sante et de la
   Recherche Medicale (INSERM); Agence Nationale de la Recherche
   [ANR-2006-PNRA-005, ANR-2007-LVIE-003, ANR-2007-LVIE-004]; Bupa
   Foundation, London; Academy of Finland, Helsinki, Finland; Bupa
   Foundation, London, U.K; National Heart, Lung, and Blood Institute
   [R01-HL-036310-20A2]; National Institute on Aging [R01-AG-034454-01];
   National Institutes of Health; MRC [G0902037] Funding Source: UKRI
FX The Fondation pour la Recherche Medicate funded the preparation and
   initiation of the study. The 3C study also is supported by the Caisse
   Nationale Maladie des Travailleurs Salaries, Direction Generale de la
   Sante, MGEN, Institut de la Longevite, Conseils Regionaux d'Aquitaine et
   Bourgogne, and the Fondation de France and Ministry of Research Institut
   National de la Sante et de la Recherche Medicale (INSERM) Programme
   "Cohortes et Collections de Donnees Biologiques." Parts of this project
   were financed by a grant from the Agence Nationale de la Recherche
   (project nos. ANR-2006-PNRA-005, ANR-2007-LVIE-003, and
   ANR-2007-LVIE-004). T.N.A. is supported by the Bupa Foundation, London,
   U.K. M.K. is supported by the Academy of Finland, Helsinki, Finland; the
   Bupa Foundation, London, U.K.; and the National Heart, Lung, and Blood
   Institute (R01-HL-036310-20A2) and the National Institute on Aging
   (R01-AG-034454-01), National Institutes of Health. The 3C study is
   conducted under a partnership agreement between the
   INSERM,Victor-Segalen Bordeaux 2 University, and sanofi-aventis. The
   funders had no role in the design and conduct of the study; collection,
   management, analysis, and interpretation of the data; and preparation,
   review, or approval of the manuscript. No potential conflicts of
   interest relevant to this article were reported.
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NR 21
TC 48
Z9 51
U1 0
U2 10
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0149-5992
EI 1935-5548
J9 DIABETES CARE
JI Diabetes Care
PD APR
PY 2011
VL 34
IS 4
BP 904
EP 909
DI 10.2337/dc10-1644
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism
GA 746DE
UT WOS:000289221800021
PM 21346185
OA Green Submitted, hybrid, Green Published, Green Accepted
DA 2025-06-11
ER

PT J
AU Ahanchi, NS
   Khatami, F
   Llanaj, E
   Quezada-Pinedo, HG
   Dizdari, H
   Bano, A
   Glisic, M
   Eisenga, MF
   Vidal, PM
   Muka, T
AF Ahanchi, Noushin Sadat
   Khatami, Farnaz
   Llanaj, Erand
   Quezada-Pinedo, Hugo G.
   Dizdari, Helga
   Bano, Arjola
   Glisic, Marija
   Eisenga, Michele F.
   Vidal, Pedro-Marques
   Muka, Taulant
TI The complementary roles of iron and estrogen in menopausal differences
   in cardiometabolic outcomes
SO CLINICAL NUTRITION
LA English
DT Review
DE Iron biomarkers; Menopause; Sex; Cardiometabolic risk factors
ID CARDIOVASCULAR RISK-FACTORS; CORONARY-HEART-DISEASE; POSTMENOPAUSAL
   HORMONE-THERAPY; ENDOGENOUS SEX-HORMONES; SERUM FERRITIN;
   INSULIN-RESISTANCE; BLOOD-PRESSURE; TRANSFERRIN RECEPTOR; METABOLIC
   SYNDROME; DIABETES-MELLITUS
AB Biological hormonal changes are frequently cited as an explanatory factor of sex and menopause differences in cardiometabolic diseases (CMD) and its associated risk factors. However, iron metabolism which varies between sexes and among women of different reproductive stages could also play a role. Recent evidence suggest that iron may contribute to CMD risk by modulating oxidative stress pathways and inflammatory responses, offering insights into the mechanistic interplay between iron and CMD development. In the current review, we provide a critical appraisal of the existing evidence on sex and menopausal differences in CMD, discuss the pitfall of current estrogen hypothesis as sole explanation, and the emerging role of iron in CMD as complementary pathway. Prior to menopause, body iron stores are lower in females as compared to males, but the increase during and after menopause, is tandem with an increased CMD risk. Importantly, basic science experiments show that an increased iron status is related to the development of type 2 diabetes (T2D), and different cardiovascular diseases (CVD). While epidemiological studies have consistently reported associations between heme iron intake and some iron biomarkers such as ferritin and transferrin saturation with the risk of T2D, the evidence regarding their connection to CVD remains controversial. We delve into the factors contributing to this inconsistency, and the limitation of relying on observational evidence, as it does not necessarily imply causation. In conclusion, we provide recommendations for future studies on evaluating the potential role of iron in elucidating the sex and menopausal differences observed in CMD. (c) 2024 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
C1 [Ahanchi, Noushin Sadat; Khatami, Farnaz; Dizdari, Helga; Bano, Arjola; Glisic, Marija] Univ Bern, Inst Social & Prevent Med, Bern, Switzerland.
   [Ahanchi, Noushin Sadat; Khatami, Farnaz] Univ Bern, Grad Sch Hlth Sci, Bern, Switzerland.
   [Ahanchi, Noushin Sadat; Vidal, Pedro-Marques] Lausanne Univ Hosp, Dept Internal Med, Internal Med, Lausanne, Switzerland.
   [Ahanchi, Noushin Sadat; Vidal, Pedro-Marques] Univ Lausanne, Lausanne, Switzerland.
   [Khatami, Farnaz] Univ Tehran Med Sci, Community Med Dept, Tehran, Iran.
   [Llanaj, Erand] German Inst Human Nutr Potsdam Rehbrucke, Dept Mol Epidemiol, Nuthetal, Germany.
   [Llanaj, Erand] German Ctr Diabet Res DZD, Munchen Neuherberg, Germany.
   [Quezada-Pinedo, Hugo G.; Bano, Arjola] Univ Bern, Bern Univ Hosp, Dept Cardiol, Bern, Switzerland.
   [Quezada-Pinedo, Hugo G.] Erasmus MC, Univ Med Ctr Rotterdam, Generat R Study Grp, Rotterdam, Netherlands.
   [Quezada-Pinedo, Hugo G.] Sophia Childrens Hosp Univ, Erasmus MC, Dept Pediat, Rotterdam, Netherlands.
   [Glisic, Marija] Swiss Parapleg Res, Nottwil, Switzerland.
   [Eisenga, Michele F.] Univ Groningen, Dept Internal Med, Div Nephrol, Groningen, Netherlands.
   [Muka, Taulant] Epistudia, Bern, Switzerland.
C3 University of Bern; University of Bern; University of Lausanne; Centre
   Hospitalier Universitaire Vaudois (CHUV); University of Lausanne; Tehran
   University of Medical Sciences; Leibniz Association; Deutsches Institut
   fur Ernahrungsforschung Potsdam-Rehbrucke (DIfE); German Center for
   Diabetes Research (DZD); University of Bern; University Hospital of
   Bern; Erasmus University Rotterdam; Erasmus MC; Erasmus University
   Rotterdam; Erasmus MC; Swiss Paraplegic Research; University of
   Groningen
RP Muka, T (corresponding author), Epistudia, Bern, Switzerland.
EM taulant.muka@epistudia.ch
RI Llanaj, Erand/B-8403-2018; Quezada Pinedo, Hugo/JCN-8939-2023;
   Marques-Vidal, Pedro/C-9449-2009
OI khatami, Farnaz/0009-0000-6247-1455; Llanaj, Erand/0000-0003-4300-0433;
   Bano, Arjola/0000-0003-0956-7145; Marques-Vidal,
   Pedro/0000-0002-4548-8500; Quezada Pinedo, Hugo
   Guillermo/0000-0002-0641-7718; Muka, Taulant/0000-0003-3235-3073
FU Swiss National Science Foun [IZLIZ3_200256]; N.S.A [2022.0415,
   2021.0899]; Swiss National Science Foundation (SNF) [IZLIZ3_200256]
   Funding Source: Swiss National Science Foundation (SNF)
FX This research was funded by the Swiss National Science Foun- dation,
   (grant no. IZLIZ3_200256) . N.S.A received funding from Swiss Government
   Excellence Scholarship (grant agreement No 2021.0899) . H.G.Q.P received
   funding from Swiss Government Excellence Scholarship (grant agreement No
   2022.0415) . The fun- ders had no role in the design of the study; in
   the collection, ana- lyses, or interpretation of data; in the writing of
   the manuscript; or in the decision to publish the results. All authors
   declare no specific funding for this contribution.
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NR 145
TC 2
Z9 2
U1 1
U2 2
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0261-5614
EI 1532-1983
J9 CLIN NUTR
JI Clin. Nutr.
PD MAY
PY 2024
VL 43
IS 5
BP 1136
EP 1150
DI 10.1016/j.clnu.2024.03.026
EA APR 2024
PG 15
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA RK4G1
UT WOS:001227538500001
PM 38593499
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Wolters, M
   Foraita, R
   Moreno, LA
   Molnar, D
   Russo, P
   Tornaritis, M
   De Henauw, S
   Lissner, L
   Veidebaum, T
   Winter, T
   Marron, M
   Nagrani, R
AF Wolters, Maike
   Foraita, Ronja
   Moreno, Luis A.
   Molnar, Denes
   Russo, Paola
   Tornaritis, Michael
   De Henauw, Stefaan
   Lissner, Lauren
   Veidebaum, Toomas
   Winter, Theresa
   Marron, Manuela
   Nagrani, Rajini
CA IDEFICS and I Family consortia
TI Longitudinal associations between vitamin D status and biomarkers of
   inflammation in a pan-European cohort of children and adolescents
SO EUROPEAN JOURNAL OF NUTRITION
LA English
DT Article
DE Children cohort; Vitamin D; Inflammatory markers; CRP; Cytokines;
   Adipokines
ID SERUM 25-HYDROXYVITAMIN D; D DEFICIENCY; CARDIOMETABOLIC RISK; METABOLIC
   SYNDROME; OBESE ADOLESCENTS; OXIDATIVE STRESS; D INSUFFICIENCY;
   ADIPOSE-TISSUE; SUPPLEMENTATION; METAANALYSIS
AB PurposeTo investigate longitudinal associations between the vitamin D status and inflammatory markers in children and adolescents.MethodsChildren from eight European countries from the IDEFICS/I.Family cohort with repeated measurements were included in this study. A linear mixed-effect model was used to model the association of serum 25(OH)D as independent variable and z-scores of inflammatory markers [CRP, cytokines, adipokines, combined inflammation score] as dependent variables, where one level accounts for differences between individuals and the other for changes over age within individuals.ResultsA total of 1,582 children were included in the study. In the adjusted model, 25(OH)D levels were positively associated with adiponectin (beta = 0.11 [95% CI 0.07; 0.16]) and negatively with the inflammation score (beta = - 0.24 [95% CI - 0.40; - 0.08]) indicating that the adiponectin z-score increased by 0.11 units and the inflammation score decreased by 0.24 units per 12.5 nmol/l increase in 25(OH)D. In children with overweight or obesity, only a positive association between 25(OH)D and IP-10 was observed while in children with normal weight adiponectin was positively and the inflammation score was negatively associated. Associations of vitamin D with adiponectin and the inflammation score were stronger in girls than in boys and a positive association with TNF-alpha was observed only in girls.ConclusionOur results suggest that an increase in vitamin D concentrations may help to regulate inflammatory biomarkers. However, it seems to be no benefit of a better vitamin D status in children with overweight/obesity unless their weight is managed to achieve an improved inflammatory marker status.
C1 [Wolters, Maike; Foraita, Ronja; Marron, Manuela; Nagrani, Rajini] Leibniz Inst Prevent Res & Epidemiol BIPS, Achter str 30, D-28359 Bremen, Germany.
   [Moreno, Luis A.] Univ Zaragoza, Inst Invest Sanitaria Aragon IIS Aragon, Inst Agroalimentario Aragon IA2, GENUD Growth Exercise Nutr & Dev Res Grp, Zaragoza, Spain.
   [Moreno, Luis A.] Inst Salud Carlos III, Ctr Invest Biomed Red Fisiopatol Obes & Nutr CIBER, Madrid, Spain.
   [Molnar, Denes] Univ Pecs, Med Sch, Dept Paediat, Pecs, Hungary.
   [Russo, Paola] CNR, Inst Food Sci, Avellino, Italy.
   [Tornaritis, Michael] Res & Educ Inst Child Hlth, Strovolos, Cyprus.
   [De Henauw, Stefaan] Univ Ghent, Dept Publ Hlth & Primary Care, Ghent, Belgium.
   [Lissner, Lauren] Univ Gothenburg, Inst Med, Sahlgrenska Acad, Sch Publ Hlth & Community Med, Gothenburg, Sweden.
   [Veidebaum, Toomas] Natl Inst Hlth Dev, Tallinn, Estonia.
   [Winter, Theresa] Univ Med Greifswald, Inst Clin Chem, Greifswald, Germany.
   [Winter, Theresa] Univ Med Greifswald, Lab Med, Greifswald, Germany.
C3 Leibniz Association; Leibniz Institute for Prevention Research &
   Epidemiology (BIPS); University of Zaragoza; Instituto de Salud Carlos
   III; University of Pecs; Consiglio Nazionale delle Ricerche (CNR);
   Istituto di Scienze dell' Alimentazione (ISA-CNR); Ghent University;
   Ghent University Hospital; University of Gothenburg; National Institute
   for Health Development - Estonia; Universitat Greifswald; Greifswald
   Medical School; Universitat Greifswald; Greifswald Medical School
RP Wolters, M (corresponding author), Leibniz Inst Prevent Res & Epidemiol BIPS, Achter str 30, D-28359 Bremen, Germany.
EM wolters@leibniz-bips.de
RI Nagrani, Rajini/W-3272-2019; Molnár, Dénes/AAB-6820-2022; Moreno,
   Luis/S-1780-2019
OI Wolters, Maike/0000-0002-4943-2141; Moreno Aznar, Luis
   A./0000-0003-0454-653X; Nagrani, Rajini/0000-0002-1708-2319
FU European Commission
FX The authors wish to thank the IDEFICS/I.Family children and their
   parents for participating in the extensive examinations. Additionally,
   the authors are grateful to the valuable support of school boards, head
   teachers and communities.
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NR 63
TC 0
Z9 0
U1 0
U2 1
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1436-6207
EI 1436-6215
J9 EUR J NUTR
JI Eur. J. Nutr.
PD DEC
PY 2024
VL 63
IS 8
BP 3047
EP 3060
DI 10.1007/s00394-024-03488-7
EA SEP 2024
PG 14
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA K7E7Q
UT WOS:001306260300006
PM 39231874
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Powell-Wiley, TM
   Poirier, P
   Burke, LE
   Després, JP
   Gordon-Larsen, P
   Lavie, CJ
   Lear, SA
   Ndumele, CE
   Neeland, IJ
   Sanders, P
   St-Onge, MP
AF Powell-Wiley, Tiffany M.
   Poirier, Paul
   Burke, Lora E.
   Despres, Jean-Pierre
   Gordon-Larsen, Penny
   Lavie, Carl J.
   Lear, Scott A.
   Ndumele, Chiadi E.
   Neeland, Ian J.
   Sanders, Prashanthan
   St-Onge, Marie-Pierre
CA Amer Heart Assoc Council Lifestyle
   Council Cardiovasc Stroke Nursing
   Council Clin Cardiology
   Council Epidemiology
   Stroke Council
TI Obesity and Cardiovascular Disease: A Scientific Statement From the
   American Heart Association
SO CIRCULATION
LA English
DT Review
DE AHA Scientific Statements; atrial fibrillation; cardiovascular diseases;
   coronary artery disease; death; sudden; heart; heart failure; obesity
ID BODY-MASS INDEX; PERCUTANEOUS CORONARY INTERVENTION; EPICARDIAL
   ADIPOSE-TISSUE; SUDDEN CARDIAC DEATH; INDUCED WEIGHT-LOSS; DOBUTAMINE
   STRESS ECHOCARDIOGRAPHY; ALL-CAUSE MORTALITY; ATRIAL-FIBRILLATION
   PREVALENCE; METABOLICALLY-HEALTHY OBESITY; CARDIOMETABOLIC RISK PROFILE
AB The global obesity epidemic is well established, with increases in obesity prevalence for most countries since the 1980s. Obesity contributes directly to incident cardiovascular risk factors, including dyslipidemia, type 2 diabetes, hypertension, and sleep disorders. Obesity also leads to the development of cardiovascular disease and cardiovascular disease mortality independently of other cardiovascular risk factors. More recent data highlight abdominal obesity, as determined by waist circumference, as a cardiovascular disease risk marker that is independent of body mass index. There have also been significant advances in imaging modalities for characterizing body composition, including visceral adiposity. Studies that quantify fat depots, including ectopic fat, support excess visceral adiposity as an independent indicator of poor cardiovascular outcomes. Lifestyle modification and subsequent weight loss improve both metabolic syndrome and associated systemic inflammation and endothelial dysfunction. However, clinical trials of medical weight loss have not demonstrated a reduction in coronary artery disease rates. In contrast, prospective studies comparing patients undergoing bariatric surgery with nonsurgical patients with obesity have shown reduced coronary artery disease risk with surgery. In this statement, we summarize the impact of obesity on the diagnosis, clinical management, and outcomes of atherosclerotic cardiovascular disease, heart failure, and arrhythmias, especially sudden cardiac death and atrial fibrillation. In particular, we examine the influence of obesity on noninvasive and invasive diagnostic procedures for coronary artery disease. Moreover, we review the impact of obesity on cardiac function and outcomes related to heart failure with reduced and preserved ejection fraction. Finally, we describe the effects of lifestyle and surgical weight loss interventions on outcomes related to coronary artery disease, heart failure, and atrial fibrillation.
C1 [Powell-Wiley, Tiffany M.] NIH, Bldg 10, Bethesda, MD 20892 USA.
   [Poirier, Paul] Univ Laval, Fac Pharm, Inst Univ Cardiol & Pneumol Quebec, Quebec City, PQ, Canada.
   [Burke, Lora E.] Univ Pittsburgh, Pittsburgh, PA 15260 USA.
   [Despres, Jean-Pierre] Univ Laval, VITAM Ctr Rech Sante Durable, Quebec City, PQ, Canada.
   [Gordon-Larsen, Penny] Univ N Carolina, Gillings Sch Global Publ Hlth, Chapel Hill, NC 27515 USA.
   [Lavie, Carl J.] Ochsner Med Ctr, New Orleans, LA USA.
   [Lear, Scott A.] Simon Fraser Univ, St Pauls Hosp Canada, Burnaby, BC, Canada.
   [Ndumele, Chiadi E.] Johns Hopkins Univ, Baltimore, MD 21218 USA.
   [Neeland, Ian J.] Univ Hosp Cleveland, Med Ctr, Cleveland, OH 44106 USA.
   [Neeland, Ian J.] Case Western Reserve Univ, Sch Med, Cleveland, OH 44106 USA.
   [Sanders, Prashanthan] Univ Adelaide, Adelaide, SA, Australia.
   [Sanders, Prashanthan] Royal Adelaide Hosp, Adelaide, SA, Australia.
   [St-Onge, Marie-Pierre] Columbia Univ, Irving Med Ctr, New York, NY 10027 USA.
C3 National Institutes of Health (NIH) - USA; Laval University; Laval
   University Hospital; Pennsylvania Commonwealth System of Higher
   Education (PCSHE); University of Pittsburgh; Laval University;
   University of North Carolina; University of North Carolina Chapel Hill;
   Ochsner Health System; Simon Fraser University; Johns Hopkins
   University; University System of Ohio; Case Western Reserve University;
   Case Western Reserve University Hospital; University Hospitals of
   Cleveland; University System of Ohio; Case Western Reserve University;
   University of Adelaide; Royal Adelaide Hospital; NewYork-Presbyterian
   Hospital; Columbia University
RP Powell-Wiley, TM (corresponding author), NIH, Bldg 10, Bethesda, MD 20892 USA.
EM tiffany.powell@nih.gov
RI Poirier, Paul/KFS-2253-2024; PowellWiley, Tiffany/MCY-2981-2025;
   St-Onge, Marie-Pierre/AAB-3523-2020; Lavie, Carl/A-6014-2011; Sanders,
   Prashanthan/D-7641-2013
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NR 319
TC 1884
Z9 1992
U1 66
U2 621
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0009-7322
EI 1524-4539
J9 CIRCULATION
JI Circulation
PD MAY 25
PY 2021
VL 143
IS 21
BP E984
EP E1010
DI 10.1161/CIR.0000000000000973
PG 27
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA SH2JJ
UT WOS:000653959500003
PM 33882682
OA Green Accepted
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Ibero-Baraibar, I
   Perez-Cornago, A
   Ramirez, MJ
   Martínez, JA
   Zulet, MA
AF Ibero-Baraibar, Idoia
   Perez-Cornago, Aurora
   Ramirez, Maria J.
   Martinez, J. Alfredo
   Zulet, M. Angeles
TI An Increase in Plasma Homovanillic Acid with Cocoa Extract Consumption
   Is Associated with the Alleviation of Depressive Symptoms in Overweight
   or Obese Adults on an Energy Restricted Diet in a Randomized Controlled
   Trial
SO JOURNAL OF NUTRITION
LA English
DT Article; Proceedings Paper
CT 9th Meeting on Nutrition Updates at University-of-Navarra
CY MAY 15-16, 2015
CL Pamplona, SPAIN
SP Univ Navarra, Biomed Res Ctr Network Physiopathol Obes & Nutr, Natl Inst Hlth Carlos III, PREvenc Dleta MEDiterranea, Int Union Nutr Sci, Gene Nutrient Interact Knowledge Act Task Force
DE cocoa; depression; dopamine; homovanillic acid; weight loss
ID METABOLIC SYNDROME; BRAIN DOPAMINE; COGNITIVE PERFORMANCE; OXIDATIVE
   STRESS; WEIGHT CHANGE; SHORT-TERM; ANXIETY; MOOD; METAANALYSIS;
   POLYPHENOLS
AB Background: Obesity has been associated with various health disorders, including psychological alterations. Cocoa consumption and weight management may produce a beneficial effect on these problems.
   Objective: The purpose of this study was to investigate the effect of cocoa extract supplementation as part of an energy-restricted diet on psychological status and peripheral dopaminergic activity in overweight or obese middle-aged subjects.
   Methods: In a 4-wk, double-blind, randomized, placebo-controlled parallel nutritional intervention, 22 men and 25 women [mean +/- SD age: 57 +/- 5 y; body mass index (kg/m(2)): 30.6 +/- 2.3] were studied. After a 1-wk run-in period, volunteers consumed 15% energy-restricted diets; one-half of the volunteers were randomly assigned to receive ready-to-eat meals supplemented with 1.4 g cocoa extract/d (645 mg total polyphenols/d), whereas the rest of the volunteers received the same meals without cocoa supplementation. Plasma monoamines [dopamine, dopac, and homovanillic acid (HVA)], monoamine oxidase (MAO), and psychological status (anxiety and depressive symptoms) were analyzed in fasting participants at baseline and endpoint. Data were analyzed over time, and regression and correlation analyses were conducted to determine the relation between variables.
   Results: Depressive symptoms decreased in both groups after the intervention (control: -9.4%, P < 0.001; cocoa: -6.3%, P = 0.008), but anxiety symptoms did not. The increase in plasma HVA was 11.5% greater in the cocoa group than in the control group (P = 0.016), but plasma dopamine, dopac, and MAO changes did not differ between groups. A negative relation between changes in depressive symptoms and changes in plasma HVA was observed in the cocoa group (beta = -0.39, P = 0.029). Moreover, the change in plasma dopamine was positively associated with the change in methylcatechin-O-glucoronide in the cocoa-supplemented group (r = 0.69, P = 0.019).
   Conclusion: The intake of cocoa extract by participants consuming a 15% energy-restricted diet contributed to an increase in plasma HVA concentrations. This change was associated with a reduction in depressive symptoms, suggesting a potential effect of cocoa extract intake on this relation. The present results are secondary analyses of a clinical trial that was registered at www.clinicaltrials.gov as NCT01596309.
C1 [Ibero-Baraibar, Idoia; Martinez, J. Alfredo; Zulet, M. Angeles] Univ Navarra, Dept Nutr Food Sci & Physiol, E-31080 Pamplona, Spain.
   [Ibero-Baraibar, Idoia; Martinez, J. Alfredo; Zulet, M. Angeles] Univ Navarra, Ctr Nutr Res, E-31080 Pamplona, Spain.
   [Perez-Cornago, Aurora] Univ Navarra, Dept Prevent Med & Publ Hlth, E-31080 Pamplona, Spain.
   [Ramirez, Maria J.] Univ Navarra, Dept Pharmacol & Toxicol, E-31080 Pamplona, Spain.
   [Ramirez, Maria J.; Martinez, J. Alfredo; Zulet, M. Angeles] Navarra Inst Hlth Res, Pamplona, Spain.
   [Martinez, J. Alfredo; Zulet, M. Angeles] Natl Inst Hlth Carlos III, Biomed Res Ctr Network Physiopathol Obes & Nutr, Madrid, Spain.
C3 University of Navarra; University of Navarra; University of Navarra;
   University of Navarra; University of Navarra; Instituto de Salud Carlos
   III
RP Martínez, JA (corresponding author), Univ Navarra, Dept Nutr Food Sci & Physiol, E-31080 Pamplona, Spain.; Martínez, JA (corresponding author), Univ Navarra, Ctr Nutr Res, E-31080 Pamplona, Spain.; Martínez, JA (corresponding author), Navarra Inst Hlth Res, Pamplona, Spain.; Martínez, JA (corresponding author), Natl Inst Hlth Carlos III, Biomed Res Ctr Network Physiopathol Obes & Nutr, Madrid, Spain.
EM jalfmtz@unav.es
RI Ramirez, Maria Javier/H-4383-2017; Martinez Hernandez, J
   Alfredo/K-8709-2014; Perez-Cornago, Aurora/C-1097-2016; Zulet, M.
   Angeles/H-1317-2017
OI Ramirez, Maria Javier/0000-0002-3488-9579; Ibero-Baraibar,
   Idoia/0000-0003-0091-8068; Martinez Hernandez, J
   Alfredo/0000-0001-5218-6941; Perez-Cornago, Aurora/0000-0002-5652-356X;
   Zulet, M. Angeles/0000-0002-3926-0892
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NR 66
TC 26
Z9 27
U1 0
U2 19
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0022-3166
EI 1541-6100
J9 J NUTR
JI J. Nutr.
PD APR
PY 2016
VL 146
IS 4
BP 897S
EP 904S
DI 10.3945/jn.115.222828
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI); Conference Proceedings Citation Index - Science (CPCI-S)
SC Nutrition & Dietetics
GA DI3RA
UT WOS:000373415000029
PM 26962189
OA Bronze
DA 2025-06-11
ER

PT J
AU Onu, A
   Trofin, DM
   Tutu, A
   Onu, I
   Galaction, AI
   Sardaru, DP
   Trofin, D
   Onita, CA
   Iordan, DA
   Matei, DV
AF Onu, Ana
   Trofin, Daniela-Marilena
   Tutu, Andrei
   Onu, Ilie
   Galaction, Anca-Irina
   Sardaru, Dragos-Petrica
   Trofin, Dan
   Onita, Cristiana Amalia
   Iordan, Daniel-Andrei
   Matei, Daniela-Viorelia
TI Integrative Strategies for Preventing and Managing Metabolic Syndrome:
   The Impact of Exercise and Diet on Oxidative Stress Reduction-A Review
SO LIFE-BASEL
LA English
DT Review
DE metabolic syndrome; oxidative stress; physical exercise; dietary
   strategies; ketogenic diet; Mediterranean diet; dietary approaches to
   stop hypertension; intermittent fasting; inflammation
ID STOP HYPERTENSION DASH; OBESITY-RELATED HYPERTENSION; FREE FATTY-ACIDS;
   LOW-CARBOHYDRATE; WEIGHT-LOSS; CARDIOVASCULAR-DISEASE; AEROBIC EXERCISE;
   NERVOUS-SYSTEM; KETOGENIC DIET; BLOOD-PRESSURE
AB Metabolic syndrome (MetS) is characterized by central obesity, insulin resistance, hypertension, dyslipidemia, and chronic inflammation, significantly increasing the risk of cardiovascular disease and type 2 diabetes. Effective management of MetS is critical, with exercise being a key intervention. This review analyzed the effects of different exercise intensities-low, moderate, and high-intensity interval training (HIIT)-on metabolic health, oxidative stress (OS), inflammation, and cardiovascular function. A search of Medline, PEDro, and EBSCO identified 2251 articles, with 159 studies published between 1999 and 2025 included after screening. Low-intensity exercise improved insulin sensitivity, reduced OS markers (e.g., MDA, 8-OHdG), and enhanced antioxidant enzyme activity. Moderate-intensity exercise showed similar benefits with notable reductions in inflammatory markers (e.g., IL-1 beta, TNF-alpha). HIIT promoted fat loss and improved metabolic markers but temporarily increased OS and inflammation. Dietary strategies also play a critical role. The Mediterranean diet and Dietary Approaches to Stop Hypertension (DASH) diets are well established, emphasizing nutrient-dense foods like unsaturated fats and fiber to reduce inflammation and manage weight. The ketogenic diet (KD), a high-fat, low-carbohydrate approach, has recently gained attention for its metabolic benefits. KD induces ketosis, improving insulin sensitivity, reducing triglycerides, and enhancing fat oxidation. Studies show KD effectively reduces body weight and glucose levels, though long-term adherence and nutrient deficiencies remain challenges. Intermittent fasting also showed potential benefits, though effects on glucose metabolism were inconsistent. This review underscores the need for tailored approaches combining exercise, diet, and fasting to optimize MetS outcomes, offering integrative strategies for prevention and management.
C1 [Onu, Ana; Trofin, Daniela-Marilena; Tutu, Andrei] Grigore T Popa Univ Med & Pharm Iasi, Doctoral Sch, Iasi 700454, Romania.
   [Onu, Ilie; Galaction, Anca-Irina; Sardaru, Dragos-Petrica; Trofin, Dan; Onita, Cristiana Amalia; Matei, Daniela-Viorelia] Grigore T Popa Univ Med & Pharm Iasi, Fac Med Bioengn, Dept Biomed Sci, Iasi 700588, Romania.
   [Onita, Cristiana Amalia] Grigore T Popa Univ Med & Pharm Iasi, Ctr Obes Biobehav Expt Res, Dept Morpho Funct Sci Pathophysiol 2, Iasi 700115, Romania.
   [Iordan, Daniel-Andrei] Dunarea Jos Univ Galati, Fac Phys Educ & Sport, Dept Individual Sports & Kinetotherapy, Galati 800008, Romania.
   [Iordan, Daniel-Andrei] Dunarea Jos Univ Galati, Ctr Phys Therapy & Rehabil, Galati 800008, Romania.
C3 Grigore T Popa University of Medicine & Pharmacy; Grigore T Popa
   University of Medicine & Pharmacy; Grigore T Popa University of Medicine
   & Pharmacy; Dunarea De Jos University Galati; Dunarea De Jos University
   Galati
RP Onu, I; Galaction, AI (corresponding author), Grigore T Popa Univ Med & Pharm Iasi, Fac Med Bioengn, Dept Biomed Sci, Iasi 700588, Romania.
EM chirila.ana@d.umfiasi.ro; dr.danielatrofin@gmail.com;
   andrei.tutu@umfiasi.ro; ilie.onu@umfiasi.ro; anca.galaction@umfiasi.ro;
   dragos-petrica.sardaru@umfiasi.ro; trofin.dan@umfiasi.ro;
   cristiana-amalia.onita@umfiasi.ro; daniel.iordan@ugal.ro;
   daniela.matei@umfiasi.ro
RI Galaction, Anca/MTC-4512-2025; Dragos Petrica, Sardaru/JRW-8972-2023;
   Onu, Ilie/AAA-6447-2020; Onu, Ana/KWU-9900-2024; Trofin,
   Dan/MTE-8918-2025; Iordan, Daniel/AAK-2206-2021
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NR 159
TC 0
Z9 0
U1 0
U2 0
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2075-1729
J9 LIFE-BASEL
JI Life-Basel
PD MAY 8
PY 2025
VL 15
IS 5
AR 757
DI 10.3390/life15050757
PG 40
WC Biology; Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics; Microbiology
GA 3CD3W
UT WOS:001496816600001
PM 40430185
DA 2025-06-11
ER

PT J
AU Li, ZL
   Woollard, JR
   Wang, SM
   Korsmo, MJ
   Ebrahimi, B
   Grande, JP
   Textor, SC
   Lerman, A
   Lerman, LO
AF Li, Zilun
   Woollard, John R.
   Wang, Shenming
   Korsmo, Michael J.
   Ebrahimi, Behzad
   Grande, Joseph P.
   Textor, Stephen C.
   Lerman, Amir
   Lerman, Lilach O.
TI Increased glomerular filtration rate in early metabolic syndrome is
   associated with renal adiposity and microvascular proliferation
SO AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
LA English
DT Article
DE renal function; obesity
ID CHRONIC KIDNEY-DISEASE; CORONARY ENDOTHELIAL DYSFUNCTION; TYPE-1
   DIABETES-MELLITUS; EARLY ATHEROSCLEROSIS; OXIDATIVE STRESS; ARTERY
   STENOSIS; EXPERIMENTAL HYPERCHOLESTEROLEMIA; RENOVASCULAR DISEASE;
   STENOTIC KIDNEY; NITRIC-OXIDE
AB Li Z, Woollard JR, Wang S, Korsmo MJ, Ebrahimi B, Grande JP, Textor SC, Lerman A, Lerman LO. Increased glomerular filtration rate in early metabolic syndrome is associated with renal adiposity and microvascular proliferation. Am J Physiol Renal Physiol 301: F1078-F1087, 2011. First published July 20, 2011; doi:10.1152/ajprenal.00333.2011.-Metabolic syndrome (MetS) is associated with glomerular hyperfiltration and is a risk factor for chronic kidney disease, but the underlying mechanisms are poorly defined. This study tested the hypothesis that increased glomerular filtration rate (GFR) in early MetS is associated with renal adiposity and microvascular proliferation. Twelve MetS-prone Ossabaw pigs were randomized to 10 wk of a standard (lean, n = 6) or atherogenic (MetS, n = 6) diet. Kidney hemodynamics and function, perirenal fat volume, and tubular dynamics were assessed in vivo by multidetector computed tomography (CT) and blood oxygen level-dependent (BOLD)-MRI. Microvascular architecture was assessed ex vivo with micro-CT. Candidate injury mechanisms were evaluated in kidney tissue by Western blotting and histology. Basal GFR, renal blood flow, and renal cortical perfusion and volume were elevated in the MetS group. Perirenal and kidney tissue fat, proximal-nephron intratubular fluid concentration, and endothelial nitric oxide synthase expression were increased in MetS. GFR levels correlated with tissue triglyceride levels. Elevated spatial density of 20- to 40-mu m cortical microvessels was accompanied by mild oxidative stress, inflammation, and with proximal tubular vacuolization. Medullary size and perfusion were relatively preserved, and BOLD-MRI showed intact medullary tubular response to furosemide. Increased GFR in early MetS is associated with renal adiposity and microvascular proliferation, which involve mainly the renal cortex and precede significant activation of oxidative stress and inflammation. Renal adiposity and proliferative microvessels may represent novel therapeutic targets for preserving renal function in early MetS.
C1 [Li, Zilun; Woollard, John R.; Korsmo, Michael J.; Ebrahimi, Behzad; Textor, Stephen C.; Lerman, Lilach O.] Mayo Clin, Div Nephrol & Hypertens, Dept Internal Med, Rochester, MN 55905 USA.
   [Grande, Joseph P.] Mayo Clin, Dept Lab Med & Pathol, Rochester, MN 55905 USA.
   [Lerman, Amir; Lerman, Lilach O.] Mayo Clin, Div Cardiovasc Dis, Rochester, MN 55905 USA.
   [Li, Zilun; Wang, Shenming] Sun Yat Sen Univ, Affiliated Hosp 1, Div Vasc Surg, Guangzhou 510275, Guangdong, Peoples R China.
C3 Mayo Clinic; Mayo Clinic; Mayo Clinic; Sun Yat Sen University
RP Lerman, LO (corresponding author), Mayo Clin, Div Nephrol & Hypertens, Dept Internal Med, 200 1st St SW, Rochester, MN 55905 USA.
EM lerman.lilach@mayo.edu
RI Lerman, Lilach/M-4962-2017; Grande, Joseph/AAG-2128-2020
OI Ebrahimi, Behzad/0000-0001-6907-7696
FU National Institutes of Health [DK73608, HL77131, HL085307,
   C06-RR018898]; China Scholarship Council under Ministry of Education of
   the People's Republic of China
FX This study was partly supported by National Institutes of Health Grants
   DK73608, HL77131, HL085307, and C06-RR018898. Z. Li is supported by the
   China Scholarship Council under the authority of the Ministry of
   Education of the People's Republic of China.
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NR 46
TC 88
Z9 98
U1 0
U2 10
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 1931-857X
J9 AM J PHYSIOL-RENAL
JI Am. J. Physiol.-Renal Physiol.
PD NOV
PY 2011
VL 301
IS 5
BP F1078
EP F1087
DI 10.1152/ajprenal.00333.2011
PG 10
WC Physiology; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology; Urology & Nephrology
GA 863GV
UT WOS:000298151700019
PM 21775485
OA Green Published
DA 2025-06-11
ER

PT J
AU Venturi, S
   Marino, M
   Cioffi, I
   Martini, D
   Del Bo', C
   Perna, S
   Riso, P
   Klimis-Zacas, D
   Porrini, M
AF Venturi, Samuele
   Marino, Mirko
   Cioffi, Iolanda
   Martini, Daniela
   Del Bo', Cristian
   Perna, Simone
   Riso, Patrizia
   Klimis-Zacas, Dorothy
   Porrini, Marisa
TI Berry Dietary Interventions in Metabolic Syndrome: New Insights
SO NUTRIENTS
LA English
DT Review
DE blueberry; raspberry; strawberry; cranberry; humans; dietary
   intervention; metabolic syndrome
ID OXIDATIVE STRESS; CRANBERRY JUICE; DOUBLE-BLIND; ENDOTHELIAL FUNCTION;
   BLACK-RASPBERRY; BLOOD-PRESSURE; UNITED-STATES; RISK-FACTORS;
   BLUEBERRIES; INFLAMMATION
AB Metabolic Syndrome (MetS) is characterized by a group of dysmetabolic conditions, including abdominal obesity, dyslipidemia, glucose intolerance and/or insulin resistance, and hypertension. Generally, MetS is accompanied by an exacerbation of oxidative stress, inflammation, and vascular dysfunction. Increasing evidence suggests that berries and berry bioactives could play a potential role in the prevention and mitigation of the risk factors associated with MetS. The present systematic review summarizes the more recently available evidence deriving from human intervention studies investigating the effect of berries in subjects with at least three out of five MetS parameters. The PubMed, Scopus, and Embase databases were systematically searched from January 2010 until December 2022. A total of 17 human intervention trials met the inclusion criteria. Most of them were focused on blueberry (n = 6), cranberry (n = 3), and chokeberry (n = 3), while very few or none were available for the other berries. If considering MetS features, the main positive effects were related to lipid profile (low and high-density lipoproteins, cholesterol, and triglycerides) following blueberries and chokeberries, while conflicting results were documented for anthropometric parameters, blood pressure, and fasting blood glucose levels. Other markers analyzed within the studies included vascular function, oxidative stress, and inflammation. Here, the main positive effects were related to inflammation with a reduction in interleukin 6 and tumor necrosis factor-alpha following the intake of different berries. In conclusion, although limited, the evidence seems to support a potential role for berries in the modulation of lipid profile and inflammation in subjects with MetS. Furthermore, high-quality intervention trials are mandatory to demonstrate the role of berries in reducing risk factors for MetS and related conditions. In the future, such a demonstration could bring the adoption of berries as a potential dietary strategy to prevent/counteract MetS and related risk factors.
C1 [Venturi, Samuele; Marino, Mirko; Cioffi, Iolanda; Martini, Daniela; Del Bo', Cristian; Perna, Simone; Riso, Patrizia; Porrini, Marisa] Univ Milan, Dept Food Environm & Nutr Sci, I-20133 Milan, Italy.
   [Klimis-Zacas, Dorothy] Univ Maine, Sch Food & Agr, Orono, ME 04469 USA.
C3 University of Milan; University of Maine System; University of Maine
   Orono
RP Del Bo', C (corresponding author), Univ Milan, Dept Food Environm & Nutr Sci, I-20133 Milan, Italy.
EM samuele.venturi@unimi.it; mirko.marino@unimi.it;
   iolanda.cioffi@unimi.it; daniela.martini@unimi.it;
   cristian.delbo@unimi.it; simone.perna@unimi.it; patrizia.riso@unimi.it;
   dorothea@maine.edu; marisa.porrini@unimi.it
RI Marino, Mirko/AAI-5389-2020; Cioffi, Iolanda/Q-1023-2019; Riso,
   Patrizia/AAC-2072-2019; Del Bò, Cristian/AFT-1534-2022; porrini,
   marisa/AAF-6788-2021; Martini, Daniela/S-2499-2019; Perna,
   Simone/Y-8892-2018; martini, daniela/D-6241-2015
OI Perna, Simone/0000-0002-2720-1473; DEL BO',
   CRISTIAN/0000-0001-7562-377X; MARINO, MIRKO/0000-0001-9913-4380;
   Venturi, Samuele/0000-0001-6473-1863; porrini,
   marisa/0000-0003-2693-3311; martini, daniela/0000-0001-8298-926X; Riso,
   Patrizia/0000-0002-9204-7257; Cioffi, Iolanda/0000-0002-1408-209X
FU Wild Blueberry Association of North America (WBANA); Belgium (FWO);
   France (INRA); Germany (BLE); Italy (MIPAAF); Latvia (IZM); Norway
   (RCN); Portugal (FCT); Spain (AEI) in the joint actions of JPI HDHL,
   JPI-OCEANS, and FACCE-JPI in 2019 under ERA-NET ERA-HDHL [696295]; Piano
   di sostegno alla Ricerca-Linea 2, azione A-grant [PSR2021_DMART,
   PSR2021_CDELB]; Universita degli Studi di Milano (PSR) [2021-GSA-Linea
   6]
FX C.D.B., P.R. and D.K.-Z. thank the Wild Blueberry Association of North
   America (WBANA) for their support. C.D.B., D.M. and P.R. thank the
   project SYSTEMIC: "An integrated approach to the challenge of
   sustainable food systems: adaptive and mitigatory strategies to address
   climate change and malnutrition" from the Knowledge Hub on Nutrition and
   Food Security that has received funding from national research funding
   parties in Belgium (FWO), France (INRA), Germany (BLE), Italy (MIPAAF),
   Latvia (IZM), Norway (RCN), Portugal (FCT), and Spain (AEI) in the joint
   actions of JPI HDHL, JPI-OCEANS, and FACCE-JPI launched in 2019 under
   ERA-NET ERA-HDHL (No. 696295). D.M. and C.D.B. extend thanks for the
   grant received from Piano di sostegno alla Ricerca-Linea 2, azione
   A-grant number PSR2021_DMART and PSR2021_CDELB. P.R. also acknowledges
   the project "One Health Action Hub: University Task Force for the
   resilience of territorial ecosystems" funded by Universita degli Studi
   di Milano (PSR 2021-GSA-Linea 6).
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NR 86
TC 6
Z9 6
U1 3
U2 12
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD APR
PY 2023
VL 15
IS 8
AR 1906
DI 10.3390/nu15081906
PG 22
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA E9KP2
UT WOS:000978647600001
PM 37111125
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Cao, J
   Sodhi, K
   Puri, N
   Monu, SR
   Rezzani, R
   Abraham, NG
AF Cao, Jian
   Sodhi, Komal
   Puri, Nitin
   Monu, Sumit R.
   Rezzani, Rita
   Abraham, Nader G.
TI High fat diet enhances cardiac abnormalities in SHR rats: Protective
   role of heme oxygenase-adiponectin axis
SO DIABETOLOGY & METABOLIC SYNDROME
LA English
DT Article
DE heme oxygenase; adiponectin; high fat diet; COX-2; oxidative stress
ID SPONTANEOUSLY HYPERTENSIVE-RATS; ACTIVATED PROTEIN-KINASE; IMPROVES
   INSULIN SENSITIVITY; LOWERS BLOOD-PRESSURE; NECROSIS-FACTOR-ALPHA;
   ENDOTHELIAL DYSFUNCTION; OXIDATIVE STRESS; METABOLIC SYNDROME;
   CARDIOVASCULAR-DISEASE; SUPEROXIDE-DISMUTASE
AB Background: High dietary fat intake is a major risk factor for development of cardiovascular and metabolic dysfunction including obesity, cardiomyopathy and hypertension.
   Methods: The present study was designed to examine effect of high fat (HF) diet on cardio-vascular structure and function in spontaneously hypertensive rats (SHR), fed HF diet for 15 weeks, a phenotype designed to mimic metabolic syndrome.
   Results: Development of metabolic syndrome like phenotype was confirmed using parameters, including body weight, total cholesterol and blood pressure levels. High fat diet impaired vascular relaxation by acetylcholine and exacerbated cardiac dysfunction in SHRs as evidenced by lower left ventricular function, and higher coronary resistance (CR) as compared to controls (p < 0.05). The histological examination revealed significant myocardial and peri-vascular fibrosis in hearts from SHRs on HF diet. This cardiac dysfunction was associated with increased levels of inflammatory cytokines, COX-2, NOX-2, TxB2 expression and increase in superoxide (O-2(-)) levels in SHR fed a HF diet (p < 0.05). HO-1 induction via cobalt-protoporphyrin (CoPP, 3 mg/kg), in HF fed rats, not only improved cardiac performance parameters, but also prevented myocardial and perivascular fibrosis. These effects of CoPP were accompanied by enhanced levels of cardiac adiponectin levels, pAMPK, peNOS and iNOS expression; otherwise significantly attenuated (p < 0.05) in HF fed SHRs. Prevention of such beneficial effects of CoPP by the concurrent administration of the HO inhibitor stannic mesoporphyrin (SnMP) corroborates the role of HO system in mediating such effects.
   Conclusion: In conclusion, this novel study demonstrates that up-regulation of HO-1 improves cardiac and vascular dysfunction by blunting oxidative stress, COX-2 levels and increasing adiponectin levels in hypertensive rats on HF diet.
C1 [Sodhi, Komal; Puri, Nitin; Monu, Sumit R.; Abraham, Nader G.] Univ Toledo, Coll Med, Dept Physiol & Pharmacol, Toledo, OH 43614 USA.
   [Cao, Jian] Chinese Peoples Liberat Army Gen Hosp, Dept Geriatr Cardiol, Beijing 100853, Peoples R China.
   [Rezzani, Rita] Univ Brescia, Div Anat, Dept Biomed Sci, Brescia, Italy.
C3 University System of Ohio; University of Toledo; Chinese People's
   Liberation Army General Hospital; University of Brescia
RP Abraham, NG (corresponding author), Univ Toledo, Coll Med, Dept Physiol & Pharmacol, Toledo, OH 43614 USA.
OI Cao, Jian/0000-0001-6728-4587; Monu, Sumit/0000-0003-1906-3063
FU NIH [DK068134, HL55601, HL34300]
FX This work was supported by NIH grants DK068134, HL55601 and HL34300
   (NGA).
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NR 57
TC 39
Z9 46
U1 0
U2 4
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1758-5996
J9 DIABETOL METAB SYNDR
JI Diabetol. Metab. Syndr.
PD DEC 23
PY 2011
VL 3
AR 37
DI 10.1186/1758-5996-3-37
PG 13
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 878MQ
UT WOS:000299261600001
PM 22196253
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Yafi, FA
   Jenkins, L
   Albersen, M
   Corona, G
   Isidori, A
   Goldfarb, S
   Maggi, M
   Nelson, CJ
   Parish, S
   Salonia, A
   Tan, R
   Mulhall, JP
   Hellstrom, WJG
AF Yafi, Faysal A.
   Jenkins, Lawrence
   Albersen, Maarten
   Corona, Giovanni
   Isidori, AndreaM.
   Goldfarb, Shari
   Maggi, Mario
   Nelson, Christian J.
   Parish, Sharon
   Salonia, Andrea
   Tan, Ronny
   Mulhall, John P.
   Hellstrom, Wayne J. G.
TI Erectile dysfunction
SO NATURE REVIEWS DISEASE PRIMERS
LA English
DT Article
ID STANDARD OPERATING PROCEDURES; URINARY-TRACT SYMPTOMS; CAVERNOUS NERVE
   INJURY; QUALITY-OF-LIFE; SERUM TESTOSTERONE LEVELS; MALE SEXUAL
   DYSFUNCTION; TERM-FOLLOW-UP; 69 YEARS OLD; CORPUS CAVERNOSUM;
   SMOOTH-MUSCLE
AB Erectile dysfunction is a multidimensional but common male sexual dysfunction that involves an alteration in any of the components of the erectile response, including organic, relational and psychological. Roles for nonendocrine (neurogenic, vasculogenic and iatrogenic) and endocrine pathways have been proposed. Owing to its strong association with metabolic syndrome and cardiovascular disease, cardiac assessment may be warranted in men with symptoms of erectile dysfunction. Minimally invasive interventions to relieve the symptoms of erectile dysfunction include lifestyle modifications, oral drugs, injected vasodilator agents and vacuum erection devices. Surgical therapies are reserved for the subset of patients who have contraindications to these nonsurgical interventions, those who experience adverse effects from (or are refractory to) medical therapy and those who also have penile fibrosis or penile vascular insufficiency. Erectile dysfunction can have deleterious effects on a man's quality of life; most patients have symptoms of depression and anxiety related to sexual performance. These symptoms, in turn, affect his partner's sexual experience and the couple's quality of life. This Primer highlights numerous aspects of erectile dysfunction, summarizes new treatment targets and ongoing preclinical studies that evaluate new pharmacotherapies, and covers the topic of regenerative medicine, which represents the future of sexual medicine.
C1 [Yafi, Faysal A.; Hellstrom, Wayne J. G.] Tulane Univ, Sch Med, Dept Urol, Box SL 42,1430 Tulane Ave, New Orleans, LA 70112 USA.
   [Jenkins, Lawrence; Mulhall, John P.] Mem Sloan Kettering Canc Ctr, Sexual & Reprod Med Program, 1275 York Ave, New York, NY 10065 USA.
   [Albersen, Maarten] Univ Leuven, Dept Dev & Regenerat, Lab Expt Urol Gene & Stem Cells Applicat, Leuven, Belgium.
   [Corona, Giovanni] Maggiore Bellaria Hosp, Endocrinol Unit, Bologna, Italy.
   [Isidori, AndreaM.] Sapienza Univ Rome, Dept Expt Med, Rome, Italy.
   [Goldfarb, Shari; Nelson, Christian J.] Mem Sloan Kettering Canc Ctr, Dept Psychiat & Behav Sci, 1275 York Ave, New York, NY 10021 USA.
   [Maggi, Mario] Univ Florence, Dept Expt Clin & Biomed Sci, Sexual Med & Androl Unit, Florence, Italy.
   [Parish, Sharon] Albert Einstein Coll Med, Med, Dept Med, Bronx, NY 10467 USA.
   [Salonia, Andrea] IRCCS Osped San Raffaele, Unit Urol, Div Expt Oncol, Milan, Italy.
   [Tan, Ronny] Tan Tock Seng Hosp, Dept Urol, Singapore, Singapore.
C3 Tulane University; Memorial Sloan Kettering Cancer Center; KU Leuven;
   AUSL di Bologna; Sapienza University Rome; Memorial Sloan Kettering
   Cancer Center; University of Florence; Yeshiva University; Montefiore
   Medical Center; Albert Einstein College of Medicine; Vita-Salute San
   Raffaele University; IRCCS Ospedale San Raffaele; Tan Tock Seng Hospital
RP Hellstrom, WJG (corresponding author), Tulane Univ, Sch Med, Dept Urol, Box SL 42,1430 Tulane Ave, New Orleans, LA 70112 USA.; Mulhall, JP (corresponding author), Mem Sloan Kettering Canc Ctr, Sexual & Reprod Med Program, 1275 York Ave, New York, NY 10065 USA.
EM mulhalj1@mskcc.org; whellst@tulane.edu
RI Isidori, Andrea/F-3062-2010; Jenkins, Lawrence/P-1888-2019; Maggi,
   Mario/AAB-8284-2019; Stefanadis, Christodoulos/ABH-2232-2020; Salonia,
   Andrea/H-1025-2016
OI Stefanadis, Christodoulos/0000-0001-5974-6454; Nelson,
   Christian/0000-0003-2141-6489; Salonia, Andrea/0000-0002-0595-7165;
   Isidori, Andrea/0000-0002-9037-5417; Jenkins, Lawrence
   C/0000-0003-0125-673X; Hellstrom, Wayne/0000-0003-1284-959X
FU Ferring; Bayer; ESSM; ISSM; Besins; Otsuka; Eli-Lilly; Menarini;
   Prostrakan; Intercept; Pfizer; Lilly; CIACT; NIH; SMSNA; American
   Medical Systems
FX M.A. has received grants from Ferring, Bayer, ESSM and ISSM, and served
   as an advisor for Sandoz, Sobi and Sanofi. G.C. has received consultancy
   fees from Bayer, Besins, Otsuka, Eli-Lilly and Menarini. A.M.I. has
   served as an advisor for Otsuka, Shire, Besins, Novartis and Menarini.
   M.M. has served as an advisor and/or received speaker's fees from Bayer,
   Ely Lilly, Menarini, Prostrakan and Intercept. C.J.N. has served as an
   unpaid advisor for American Medical Systems. S.P. has served as an
   advisor for Pfizer, Sprout Pharmaceuticals, Emotional Brain and
   Strategic Science Technologies, and received speaker's fees from Pfizer.
   R.T. has served as an advisor for Lilly and Orient Europharma, and
   received speaker's fees from Lilly. J.P.M. has received grants from
   CIACT, NIH and SMSNA, and served as an advisor for Lilly, Pfizer and
   AMS. W.J.G.H. has served as an advisor for Abbvie, American Medical
   Systems, Coloplast and Pfizer. The other authors declare no competing
   interests.
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NR 225
TC 558
Z9 601
U1 9
U2 87
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 2056-676X
J9 NAT REV DIS PRIMERS
JI Nat. Rev. Dis. Primers
PD FEB 4
PY 2016
VL 2
AR 16003
DI 10.1038/nrdp.2016.3
PG 20
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA DT3BO
UT WOS:000381355700001
PM 27188339
OA Green Accepted
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Stefanaki, K
   Karagiannakis, DS
   Peppa, M
   Vryonidou, A
   Kalantaridou, S
   Goulis, DG
   Psaltopoulou, T
   Paschou, SA
AF Stefanaki, Katerina
   Karagiannakis, Dimitrios S.
   Peppa, Melpomeni
   Vryonidou, Andromachi
   Kalantaridou, Sophia
   Goulis, Dimitrios G.
   Psaltopoulou, Theodora
   Paschou, Stavroula A.
TI Food Cravings and Obesity in Women with Polycystic Ovary Syndrome:
   Pathophysiological and Therapeutic Considerations
SO NUTRIENTS
LA English
DT Review
DE polycystic ovary syndrome; obesity; food disorders; binge eating; food
   cravings
ID NUCLEUS-TRACTUS-SOLITARIUS; HORMONE-BINDING GLOBULIN; ALPHA-EXPRESSING
   CELLS; INSULIN-RESISTANCE; METABOLIC SYNDROME; INCREASED RISK; GHRELIN
   LEVELS; WEIGHT-LOSS; LUTEINIZING-HORMONE; ADOLESCENT GIRLS
AB Polycystic ovary syndrome (PCOS), the most common endocrine disorder in women of reproductive age, constitutes a metabolic disorder frequently associated with obesity and insulin resistance (IR). Furthermore, women with PCOS often suffer from excessive anxiety and depression, elicited by low self-esteem due to obesity, acne, and hirsutism. These mood disorders are commonly associated with food cravings and binge eating. Hypothalamic signaling regulates appetite and satiety, deteriorating excessive food consumption. However, the hypothalamic function is incapable of compensating for surplus food in women with PCOS, leading to the aggravation of obesity and a vicious circle. Hyperandrogenism, IR, the reduced secretion of cholecystokinin postprandially, and leptin resistance defined by leptin receptors' knockout in the hypothalamus have been implicated in the pathogenesis of hypothalamic dysfunction and appetite dysregulation. Diet modifications, exercise, and psychological and medical interventions have been applied to alleviate food disorders, interrupting the vicious circle. Cognitive-behavioral intervention seems to be the mainstay of treatment, while the role of medical agents, such as GLP-1 analogs and naltrexone/bupropion, has emerged.
C1 [Stefanaki, Katerina; Psaltopoulou, Theodora; Paschou, Stavroula A.] Natl & Kapodistrian Univ Athens, Alexandra Hosp, Sch Med, Dept Clin Therapeut,Endocrine Unit, Athens 11527, Greece.
   [Stefanaki, Katerina; Psaltopoulou, Theodora; Paschou, Stavroula A.] Natl & Kapodistrian Univ Athens, Alexandra Hosp, Diabet Ctr, Sch Med,Dept Clin Therapeut, Athens 11527, Greece.
   [Karagiannakis, Dimitrios S.] Natl & Kapodistrian Univ Athens, Sch Med, Acad Dept Gastroenterol, Laiko Gen Hosp, Athens 11527, Greece.
   [Peppa, Melpomeni] Attikon Univ Hosp, Natl & Kapodistrian Univ Athens, Sch Med, Dept Internal Med 2,Endocrine Unit, Athens 11527, Greece.
   [Peppa, Melpomeni] Natl & Kapodistrian Univ Athens, Attikon Univ Hosp, Diabet Ctr, Sch Med,Dept Internal Med 2, Athens 11527, Greece.
   [Peppa, Melpomeni] Natl & Kapodistrian Univ Athens, Sotiria Chest Dis Hosp, Med Sch, Dept Internal Med 3, Athens 11527, Greece.
   [Vryonidou, Andromachi] Hellen Red Cross Hosp, Dept Endocrinol, Athens 11526, Greece.
   [Vryonidou, Andromachi] Hellen Red Cross Hosp, Diabet Ctr, Athens 11526, Greece.
   [Kalantaridou, Sophia] Attikon Univ Hosp, Natl & Kapodistrian Univ Athens, Sch Med, Dept Obstet & Gynecol 3, Athens 11527, Greece.
   [Goulis, Dimitrios G.] Aristotle Univ Thessaloniki, Sch Med, Dept Obstet & Gynecol 1, Unit Reprod Endocrinol, Thessaloniki 57001, Greece.
C3 Alexandra Hospital; Athens Medical School; National & Kapodistrian
   University of Athens; Alexandra Hospital; National & Kapodistrian
   University of Athens; Athens Medical School; Laiko General Hospital;
   National & Kapodistrian University of Athens; Athens Medical School;
   National & Kapodistrian University of Athens; Athens Medical School;
   University Hospital Attikon; National & Kapodistrian University of
   Athens; Athens Medical School; University Hospital Attikon; National &
   Kapodistrian University of Athens; National & Kapodistrian University of
   Athens; University Hospital Attikon; Athens Medical School; Aristotle
   University of Thessaloniki
RP Karagiannakis, DS (corresponding author), Natl & Kapodistrian Univ Athens, Sch Med, Acad Dept Gastroenterol, Laiko Gen Hosp, Athens 11527, Greece.
EM k.stefanaki@hotmail.gr; dkarag@med.uoa.gr; moly6592@yahoo.com;
   mahi_vr@hotmail.com; sophiakalantaridou@gmail.com; tpsaltop@hotmail.com;
   s.a.paschou@gmail.com
RI Goulis, Dimitrios/AAG-4589-2020; S Karagiannakis,
   Dimitrios/AFQ-7294-2022
OI Paschou, Stavroula/0000-0002-0651-1376; Peppa,
   Melpomeni/0000-0002-3538-2534; S Karagiannakis,
   Dimitrios/0000-0003-0082-634X; Goulis, Dimitrios/0000-0002-5005-1995
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NR 130
TC 2
Z9 2
U1 4
U2 8
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD APR
PY 2024
VL 16
IS 7
AR 1049
DI 10.3390/nu16071049
PG 15
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA NN7X2
UT WOS:001201205700001
PM 38613082
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Kim, M
   Paik, JK
   Kang, R
   Kim, SY
   Lee, SH
   Lee, JH
AF Kim, Minjoo
   Paik, Jean Kyung
   Kang, Ryungwoo
   Kim, Soo Young
   Lee, Sang-Hyun
   Lee, Jong Ho
TI Increased oxidative stress in normal-weight postmenopausal women with
   metabolic syndrome compared with metabolically healthy overweight/obese
   individuals
SO METABOLISM-CLINICAL AND EXPERIMENTAL
LA English
DT Article
DE Metabolic syndrome; Weight; Postmenopausal women; Oxidative stress
ID LOW-DENSITY-LIPOPROTEIN; CHRONIC KIDNEY-DISEASE; C-REACTIVE PROTEIN;
   INSULIN-RESISTANCE; OBESE; INFLAMMATION; RISK; PHENOTYPES; MEN;
   POPULATION
AB Objective. The purpose of this study was to assess whether the metabolically healthy overweight/obese phenotype is associated with decreased oxidative stress compared with normal-weight individuals with metabolic syndrome (MetS).
   Materials/Methods. Plasma oxidized LDL (ox-LDL) and urinary 8-epi-prostaglandin F-2 alpha (8-epi-PGF(2 alpha)) were analyzed in a cross-sectional study of 1846 healthy postmenopausal women. Participants were classified by presence (n=569) or absence (n=1277) of MetS and by BMI (18.5-24.9 kg/m(2)=normal weight, n=1254; >= 25 kg/m(2)=overweight/obese, n=592). MetS was diagnosed with the modified National Cholesterol Education Program Adult Treatment Panel III criteria.
   Results. Compared to normal weight women with MetS (n=296), metabolically healthy overweight/obese women (n=319) showed lower blood pressure, triglyceride, and glucose and higher HDL cholesterol, adiponectin, and LDL particle size. Ox-LDL was higher in overweight/obese women without MetS than in normal weight women without MetS (n=958) but was lower than in women with MetS. Urinary 8-epi-PGF(2 alpha) level was about 11% lower in women without MetS than in women with MetS. Normal weight women with MetS had greater odds of having ox-LDL (multivariate odds ratio [OR] 2.42, 95% CI: 1.65-3.55) and 8-epi-PGF(2 alpha) (OR 1.49; CI: 1.03-2.14) levels in the top quartile compared to normal weight women without MetS after adjusting for age, drinking, smoking, total- and LDL-cholesterol, and high sensitivity C-reactive protein. Additionally, there was no significant correlation between ox-LDL and 8-epi-PGF(2 alpha).
   Conclusions. The metabolically healthy overweight/obese phenotype was associated with a better overall metabolic profile and less oxidative stress than that observed in normal weight individuals with MetS. Furthermore, there was a lack of association between ox-LDL and 8-epi-PGF(2 alpha). (C) 2013 Elsevier Inc. All rights reserved.
C1 [Kim, Minjoo; Kang, Ryungwoo; Lee, Jong Ho] Yonsei Univ, Coll Human Ecol, Dept Food & Nutr, Natl Leading Res Lab Clin Nutrigenet Nutrigen, Seoul 120749, South Korea.
   [Kim, Minjoo; Kang, Ryungwoo; Lee, Jong Ho] Yonsei Univ, Coll Human Ecol, Dept Food & Nutr, Brain Korea Project 21, Seoul 120749, South Korea.
   [Paik, Jean Kyung; Lee, Jong Ho] Yonsei Univ, Res Inst Sci Aging, Seoul 120749, South Korea.
   [Kim, Soo Young] Yonsei Univ, Interdisciplinary Course Sci Aging, Seoul 120749, South Korea.
   [Lee, Sang-Hyun] Natl Hlth Insurance Corp Ilsan Hosp, Dept Family Practice, Goyang Si, South Korea.
C3 Yonsei University; Yonsei University; Yonsei University; Yonsei
   University
RP Lee, JH (corresponding author), Yonsei Univ, Coll Human Ecol, Dept Food & Nutr, 134 Shinchon Dong, Seoul 120749, South Korea.
EM jhleeb@yonsei.ac.kr
RI Kim, Minjoo/AEN-5516-2022; Kang, Hyun-Seung/J-5365-2012
FU Korean National Health Insurance Corporation; National Research
   Foundation of Korea, Republic of Korea [M10642120002-06N4212-00210,
   2012-0005604, 2012M3A9C4048762]; National Research Foundation of Korea
   [2012M3A9C4048762] Funding Source: Korea Institute of Science &
   Technology Information (KISTI), National Science & Technology
   Information Service (NTIS)
FX We would like to thank all study participants. This work was supported
   by the Korean National Health Insurance Corporation and the Mid-career
   Researcher Program through National Research Foundation of Korea
   (M10642120002-06N4212-00210, 2012-0005604, and 2012M3A9C4048762),
   Republic of Korea.
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NR 33
TC 50
Z9 54
U1 0
U2 7
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0026-0495
EI 1532-8600
J9 METABOLISM
JI Metab.-Clin. Exp.
PD APR
PY 2013
VL 62
IS 4
BP 554
EP 560
DI 10.1016/j.metabol.2012.10.006
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 125HL
UT WOS:000317530800011
PM 23142163
DA 2025-06-11
ER

PT J
AU Russo, E
   Viazzi, F
   Pontremoli, R
   Angeli, F
   Barbagallo, CM
   Berardino, B
   Bombelli, M
   Cappelli, F
   Casiglia, E
   Cianci, R
   Ciccarelli, M
   Cicero, AFG
   Cirillo, M
   Cirillo, P
   D'Elia, L
   Desideri, G
   Ferri, C
   Galletti, F
   Gesualdo, L
   Giannattasio, C
   Grassi, G
   Iaccarino, G
   Imbalzano, E
   Lippa, L
   Mallamaci, F
   Maloberti, A
   Masi, S
   Masulli, M
   Mazza, A
   Mengozzi, A
   Muiesan, ML
   Nazzaro, P
   Palatini, P
   Parati, G
   Quarti-Trevano, F
   Rattazzi, M
   Reboldi, G
   Rivasi, G
   Salvetti, M
   Tikhonoff, V
   Tocci, G
   Ungar, A
   Verdecchia, P
   Virdis, A
   Volpe, M
   Borghi, C
AF Russo, Elisa
   Viazzi, Francesca
   Pontremoli, Roberto
   Angeli, Fabio
   Barbagallo, Carlo Maria
   Berardino, Bruno
   Bombelli, Michele
   Cappelli, Federica
   Casiglia, Edoardo
   Cianci, Rosario
   Ciccarelli, Michele
   Cicero, Arrigo F. G.
   Cirillo, Massimo
   Cirillo, Pietro
   D'Elia, Lanfranco
   Desideri, Giovambattista
   Ferri, Claudio
   Galletti, Ferruccio
   Gesualdo, Loreto
   Giannattasio, Cristina
   Grassi, Guido
   Iaccarino, Guido
   Imbalzano, Egidio
   Lippa, Luciano
   Mallamaci, Francesca
   Maloberti, Alessandro
   Masi, Stefano
   Masulli, Maria
   Mazza, Alberto
   Mengozzi, Alessandro
   Muiesan, Maria Lorenza
   Nazzaro, Pietro
   Palatini, Paolo
   Parati, Gianfranco
   Quarti-Trevano, Fosca
   Rattazzi, Marcello
   Reboldi, Gianpaolo
   Rivasi, Giulia
   Salvetti, Massimo
   Tikhonoff, Valerie
   Tocci, Giuliano
   Ungar, Andrea
   Verdecchia, Paolo
   Virdis, Agostino
   Volpe, Massimo
   Borghi, Claudio
CA Italian Soc Hypertension SIIA
TI Predictive value of TG/HDL-C and GFR-adjusted uric acid levels on
   cardiovascular mortality: the URRAH study
SO LIPIDS IN HEALTH AND DISEASE
LA English
DT Article
DE TG/HDL-C ratio; Triglycerides; Insulin-resistance; Uric acid; Kidney
   function; Cardiovascular mortality
ID CHRONIC KIDNEY-DISEASE; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   CHOLESTEROL RATIO; CARDIOMETABOLIC RISK; ARTERIAL STIFFNESS; OXIDATIVE
   STRESS; TRIGLYCERIDE; PROGRESSION; OUTCOMES
AB BackgroundInsulin resistance (IR) and serum uric acid (SUA) are closely interconnected: SUA contributes to adversely affects the insulin signaling pathway and contributes to IR, while IR is a known predictor for the development of hyperuricemia. The triglyceride (TG) to high-density lipoprotein cholesterol (HDL-C) ratio has been proposed as an easily obtainable marker for IR. This research aimed to investigate the interaction between IR and glomerular filtration rate (GFR)-adjusted uricemia (SUA/GFR ratio) in determining CV risk in a large population cohort study.MethodsData from 18,694 subjects were analyzed from Uric acid Right foR heArt Healt (URRAH) database. The study evaluated the association between TG/HDL-C ratio and SUA/GFR ratio, as well as their impact on the development of outcomes during the follow-up study period. The primary endpoint was CV mortality.ResultsAfter a mean follow-up of 124 +/- 64 months, 2,665 (14.2%) CV deaths occurred. The incidence of fatal and non-fatal CV events increased in parallel with the increase of TG/HDL-C quintiles. TG/HDL-C ratio showed a positive association with increasing of SUA/GFR ratio, even in non-diabetic patients. Multivariate analysis showed that the TG/HDL-C ratio increases the mortality risk even after adjustment for potential confounding factors. Finally, IR and GFR-adjusted hyperuricemia showed an additive effect on CV mortality.ConclusionsBoth IR and SUA/GFR ratio independently predict CV mortality, regardless of age, gender, BMI, diabetes, hypertension and statin use. The joint effect of the TG/HDL-C ratio and the elevated SUA/GFR ratio was greater than the presence of each single risk factor on CV mortality. This highlights the importance of monitoring these markers to better assess cardiovascular risk.
C1 [Russo, Elisa; Viazzi, Francesca; Pontremoli, Roberto] Univ Genoa, Dipartimento Med Interna & Special Med, Genoa, Liguria, Italy.
   [Russo, Elisa; Viazzi, Francesca; Pontremoli, Roberto] IRCCS Osped Policlin San Martino, Genoa, Liguria, Italy.
   [Angeli, Fabio] Univ Insubria, Varese, Lombardy, Italy.
   [Angeli, Fabio] Ist Clin Sci Maugeri SpA IRCCS Tradate, Tradate, Lombardy, Italy.
   [Barbagallo, Carlo Maria] Univ Palermo, Dipartimento Promoz Salute Maternoinfantile Med I, Palermo, Italy.
   [Berardino, Bruno; Ferri, Claudio] Univ Aquila, Dipartimento Med Clin Sanita Pubbl Sci Vita & Amb, Laquila, Abruzzo, Italy.
   [Bombelli, Michele] Univ Milano Bicocca, Dipartimento Med & Chirurg, Milan, Lombardy, Italy.
   [Cappelli, Federica; Masi, Stefano; Mengozzi, Alessandro; Virdis, Agostino] Univ Pisa, Dipartimento Med Clin & Sperimentale, Pisa, Tuscany, Italy.
   [Casiglia, Edoardo; Palatini, Paolo; Tikhonoff, Valerie] Univ Padua, Dipartimento Med, Padua, Veneto, Italy.
   [Cianci, Rosario] Univ Roma La Sapienza, Dipartimento Med Traslaz & Precis, Rome, Lazio, Italy.
   [Ciccarelli, Michele] Univ Salerno, Dipartimento Med Chirurg & Odontoiatria, Scuola Med Salernitana, Baronissi, Campania, Italy.
   [Cicero, Arrigo F. G.; Borghi, Claudio] Univ Bologna, Dipartimento Sci Med & Chirurg, Bologna, Emilia Romagna, Italy.
   [Borghi, Claudio] IRCCS Azienda Osped Univ Bologna, Dipartimento Malattie Cardiotoraco Vasc, Policlin St Orsola, Bologna, Emilia Romagna, Italy.
   [Cirillo, Massimo] Univ Salerno, Dipartimento Med Chirurg & Odontoiatria, Scuola Med Salernitana, Salerno, Campania, Italy.
   [Cirillo, Pietro; Gesualdo, Loreto] Univ Bari Aldo Moro, Dipartimento Emergenza & Trapianti Organi, Bari, Italy.
   [D'Elia, Lanfranco; Galletti, Ferruccio; Iaccarino, Guido; Masulli, Maria] Univ Napoli Federico II, Dipartimento Med Clin & Chirurg, Naples, Campania, Italy.
   [Desideri, Giovambattista] Univ Roma Sapienza, Dipartimento Sci Clin Internist Anestesiol & Card, Rome, Lazio, Italy.
   [Giannattasio, Cristina; Maloberti, Alessandro] ASST Grande Osped Metropolitano Niguarda De Gaspe, Cardio Ctr, Milan, Lombardy, Italy.
   [Giannattasio, Cristina; Grassi, Guido; Maloberti, Alessandro; Quarti-Trevano, Fosca] Univ Milano Bicocca, Scuola Med & Chirurg, Monza, Lombardy, Italy.
   [Imbalzano, Egidio] Univ Messina, Dipartimento Med Clin & Sperimentale, Messina, Sicily, Italy.
   [Lippa, Luciano] Soc Italiana Med Med Gen, Avezzano, Abruzzo, Italy.
   [Mallamaci, Francesca] Azienda Osped Bianchi Melacrino Morelli, Calabria, Italy.
   [Mallamaci, Francesca] CNR, Ist Fisiol Clin, Sez Reggio Calabria, Calabria, Italy.
   [Mazza, Alberto] Osped S Maria Misericordia, Rovigo, Veneto, Italy.
   [Muiesan, Maria Lorenza; Salvetti, Massimo] Univ Brescia, Dipartimento Sci Clin & Sperimentali, Brescia, Lombardy, Italy.
   [Nazzaro, Pietro] Univ Bari Aldo Moro, Dipartimento Med Precis & Rigenerat, Bari, Apulia, Italy.
   [Nazzaro, Pietro] Univ Bari Aldo Moro, Area Jon, Bari, Apulia, Italy.
   [Parati, Gianfranco] Ist Auxol Italiano, Ist Sci San Luca, Milan, Lombardy, Italy.
   [Parati, Gianfranco] Univ Milano Bicocca, Milan, Lombardy, Italy.
   [Rattazzi, Marcello] Ca Foncello Univ Padua, Dept Med DIMED, Med Interna 1, Treviso, Veneto, Italy.
   [Reboldi, Gianpaolo] Univ Perugia, Dipartimento Med & Chirurg, Perugia, Italy.
   [Tocci, Giuliano; Volpe, Massimo] Univ Roma La Sapienza, Dipartimento Med Clin & Mol, Rome, Lazio, Italy.
   [Tocci, Giuliano] Azienda Osped St Andrea, Dipartimento Sci Med, Rome, Lazio, Italy.
   [Verdecchia, Paolo] Azienda Osped Perugia, Perugia, Umbria, Italy.
   [Volpe, Massimo] IRCCS San Raffaele, Rome, Lazio, Italy.
C3 University of Genoa; University of Genoa; IRCCS AOU San Martino IST;
   University of Insubria; University of Palermo; University of L'Aquila;
   University of Milano-Bicocca; University of Pisa; University of Padua;
   Sapienza University Rome; University of Salerno; University of Bologna;
   IRCCS Azienda Ospedaliero-Universitaria di Bologna; University of
   Salerno; Universita degli Studi di Bari Aldo Moro; University of Naples
   Federico II; Sapienza University Rome; University of Milano-Bicocca;
   University of Messina; Consiglio Nazionale delle Ricerche (CNR);
   Hospital Santa Maria della Misericordia; University of Brescia;
   Universita degli Studi di Bari Aldo Moro; Universita degli Studi di Bari
   Aldo Moro; IRCCS Istituto Auxologico Italiano; University of
   Milano-Bicocca; University of Perugia; Sapienza University Rome;
   Sapienza University Rome; Azienda Ospedaliera Sant'Andrea; University of
   Perugia; Azienda Ospedaliera di Perugia; IRCCS San Raffaele Pisana;
   Vita-Salute San Raffaele University; IRCCS Ospedale San Raffaele
RP Viazzi, F (corresponding author), Univ Genoa, Dipartimento Med Interna & Special Med, Genoa, Liguria, Italy.; Viazzi, F (corresponding author), IRCCS Osped Policlin San Martino, Genoa, Liguria, Italy.
EM francesca.viazzi@unige.it
RI Viazzi, Francesca/AAB-2479-2019; Imbalzano, Egidio/A-2063-2015;
   Maloberti, Alessandro/Q-1244-2017; Rivasi, Giulia/ISB-2204-2023; Russo,
   Elisa/AAH-2246-2021; Tikhonoff, Valerie/AAC-3728-2019; Cianci,
   Rosario/AAS-7708-2020; Mengozzi, Alessandro/JSK-7085-2023; Tocci,
   Giuliano/K-4901-2018; Muiesan, M.L./AAC-2060-2022; Cicero,
   Arrigo/H-8244-2019; Rattazzi, Marcello/AAP-6251-2020; Cirillo,
   Pietro/HPE-7114-2023; D'Elia, Lanfranco/U-6499-2017; Cirillo,
   Massimo/G-5480-2018
OI Cicero, Arrigo Francesco Giuseppe/0000-0002-4367-3884; Tikhonoff,
   Valerie/0000-0001-7846-0101; Cirillo, Massimo/0000-0002-6409-3504
FU Fondazione of the Italian Society of Hypertension
FX This work has been conducted with an unrestricted grant from the
   Fondazione of the Italian Society of Hypertension (grant: MIOL).
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NR 71
TC 0
Z9 0
U1 1
U2 1
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1476-511X
J9 LIPIDS HEALTH DIS
JI Lipids Health Dis.
PD JAN 24
PY 2025
VL 24
IS 1
AR 21
DI 10.1186/s12944-025-02440-w
PG 11
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA T6J7M
UT WOS:001406049000001
PM 39856749
OA gold
DA 2025-06-11
ER

PT J
AU Krishnan, S
   Gertz, ER
   Adams, SH
   Newman, JW
   Pedersen, TL
   Keim, NL
   Bennett, BJ
AF Krishnan, Sridevi
   Gertz, Erik R.
   Adams, Sean H.
   Newman, John W.
   Pedersen, Theresa L.
   Keim, Nancy L.
   Bennett, Brian J.
TI Effects of a diet based on the Dietary Guidelines on vascular health and
   TMAO in women with cardiometabolic risk factors
SO NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
LA English
DT Article
DE Dietary guidelines diet pattern; Endothelial dysfunction; Controlled
   feeding trial
ID TRIMETHYLAMINE-N-OXIDE; ENDOTHELIAL FUNCTION; METABOLIC SYNDROME;
   L-CARNITINE; CARDIOVASCULAR RISK; OXIDATIVE STRESS; GUT MICROBIOTA;
   DYSFUNCTION; CHOLINE; INFLAMMATION
AB Background and aims: Recent evidence links trimethylamine oxide (TMAO) to endothelial dysfunction, an early indicator of cardiovascular disease. We aimed to determine whether short-term consumption of a diet patterned after the 2010 Dietary Guidelines for Americans (DGA) would affect endothelial function, plasma TMAO concentrations, and cardiovascular disease risk, differently than a typical American Diet (TAD). Methods and results: An 8-wk controlled feeding trial was conducted in overweight/obese women pre-screened for insulin resistance and/or dyslipidemia. Women were randomized to a DGA or TAD group (n = 22/group). At wk0 (pre-intervention) and wk8 (post-intervention) vascular age was calculated; endothelial function (reactive hyperemia index (RHI)) and augmentation index (AI@75) were measured using EndoPAT, and plasma TMAO was measured by LC-MS/ MS. Vascular age was reduced in DGA at wk8 compared to wk0 but TAD wk8 was not different from wk0 (DGA wk0: 54.2 +/- 4.0 vs. wk8: 50.5 +/- 3.1 (p = 0.05), vs. TAD wk8: 47.7 +/- 2.3). Plasma TMAO concentrations, RHI, and AI@75 were not different between groups or weeks. Conclusion: Consumption of a diet based on the 2010 Dietary Guidelines for Americans for 8 weeks did not improve endothelial function or reduce plasma TMAO. Clinicaltrials.gov: NCT02298725. Published by Elsevier B.V. on behalf of The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. This is an open access article under the CC BY-NC ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
C1 [Krishnan, Sridevi; Gertz, Erik R.; Newman, John W.; Keim, Nancy L.; Bennett, Brian J.] USDA, Western Human Nutr Res Ctr, Davis, CA 95616 USA.
   [Krishnan, Sridevi; Newman, John W.; Keim, Nancy L.; Bennett, Brian J.] Univ Calif Davis, Dept Nutr, Davis, CA USA.
   [Adams, Sean H.] Univ Calif Davis, Dept Surg, Sch Med, Sacramento, CA USA.
   [Adams, Sean H.] Univ Calif Davis, Sch Med, Ctr Alimentary & Metab Sci, Sacramento, CA 95817 USA.
   [Pedersen, Theresa L.] Univ Calif Davis, Dept Food Sci & Technol, Davis, CA USA.
C3 United States Department of Agriculture (USDA); University of California
   System; University of California Davis; University of California System;
   University of California Davis; University of California System;
   University of California Davis; University of California System;
   University of California Davis
RP Bennett, BJ (corresponding author), USDA, Obes & Metab Res Unit, Western Human Nutr Res Ctr, 430 W Hlth Sci Dr, Davis, CA 95616 USA.
EM brian.bennett@usda.gov
RI ADAMS, SEAN/N-9262-2018; bennett, brian/ADY-4361-2022
OI Keim, Nancy/0000-0002-6601-7572; Krishnan, Sridevi/0000-0003-2757-6934;
   Newman, John/0000-0001-9632-6571; bennett, brian/0000-0002-0766-3195
FU National Dairy Council; Campbell Soup Co.; USDAARS Projects
   [2032-51530-022-00D, 6026-51000-010-05S]
FX This trial was registered at clinicaltrials.gov as NCT02298725. The
   feeding trial was supported by the National Dairy Council and Campbell
   Soup Co., and USDAARS Projects 2032-51530-022-00D and 6026-51000-01005S.
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NR 66
TC 12
Z9 13
U1 0
U2 6
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 0939-4753
EI 1590-3729
J9 NUTR METAB CARDIOVAS
JI Nutr. Metab. Carbiovasc. Dis.
PD JAN
PY 2022
VL 32
IS 1
BP 210
EP 219
DI 10.1016/j.numecd.2021.09.013
EA DEC 2021
PG 10
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism; Nutrition
   & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism;
   Nutrition & Dietetics
GA XY4YY
UT WOS:000736981100023
PM 34895998
OA Green Accepted, Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Eggers, AE
AF Eggers, Arnold E.
TI Extending David Horrobin's membrane phospholipid theory of
   schizophrenia: Overactivity of cytosolic phospholipase A2 in
   the brain is caused by overdrive of coupled serotonergic
   5HT2A/2C receptors in response to stress
SO MEDICAL HYPOTHESES
LA English
DT Article
ID ADIPOSE-TISSUE DEVELOPMENT; INSULIN-RESISTANCE; MIDBRAIN RAPHE; ACID;
   RAT; NEUROGENESIS; 1ST-EPISODE; INVOLVEMENT; METABOLISM; MIGRAINE
AB David Horrobin's membrane phospholipid theory of schizophrenia has held up well over time because his therapeutic prediction that dietary supplementation with eicosapentaenoic acid (EPA) would have a therapeutic effect has been partially verified and undergoes continued testing. In the final version of his theory, he hypothesized that there was hyperactivity of phosphoslipase A(2) (PLA(2)) or a related enzyme but did not explain how the hyperactivity came about. It is known that serotonergic 5HT(2A/2C) receptors are coupled to PLA(2), which hydrolyzes both arachidonic acid (AA) and EPA from diacylglycerides at the sn-2 position. In this paper, Horrobin's theory is combined with a previously published theory of chronic stress in which it was hypothesized that a disinhibited dorsal raphe nucleus, the principal nucleus of the serotonergic system, can organize the neuropathology of diseases such as migraine, hypertension, and the metabolic syndrome. The new or combined theory is that schizophrenia is a disease of chronic stress in which a disinhibited DRN causes widespread serotonergic overdrive in the cerebral cortex. This in turn causes overdrive of cPLA(2) and both central and peripheral depletion of M and EPA. Because EPA is present in smaller amounts, it falls below threshold for maintaining an intracellular balance between AA-derived and EPA-derived second messenger cascades, which leads to abnormal patterns of neuronal firing. There are two causes of neuronal dysfunction: the disinhibited DRN and EPA depletion. Schizophrenia is statistically associated with metabolic syndrome, hypertension, and migraine because they form a cluster of diseases with similar pathophysiology.
   The theory provides an explanation for both the central and peripheral phospholipid abnormalities in schizophrenia. It also explains the role of stress in schizophrenia, elevated serum PLA(2) activity in schizophrenia, the relationship between untreated schizophrenia and metabolic syndrome, and the therapeutic rationale for EPA. (C) 2012 Elsevier Ltd. All rights reserved.
C1 [Eggers, Arnold E.] Suny Downstate Med Ctr, Dept Neurol, Brooklyn, NY 11203 USA.
   [Eggers, Arnold E.] Kings Cty Hosp, Brooklyn, NY 11203 USA.
C3 State University of New York (SUNY) System; SUNY Downstate Health
   Sciences University
RP Eggers, AE (corresponding author), Suny Downstate Med Ctr, Dept Neurol, Box 1213, Brooklyn, NY 11203 USA.
EM eggersa@aol.com
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NR 33
TC 8
Z9 9
U1 1
U2 5
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0306-9877
J9 MED HYPOTHESES
JI Med. Hypotheses
PD DEC
PY 2012
VL 79
IS 6
BP 740
EP 743
DI 10.1016/j.mehy.2012.08.016
PG 4
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 046OE
UT WOS:000311773500009
PM 22986004
DA 2025-06-11
ER

PT J
AU Jakubiak, GK
   Osadnik, K
   Lejawa, M
   Osadnik, T
   Golawski, M
   Lewandowski, P
   Pawlas, N
AF Jakubiak, Grzegorz K.
   Osadnik, Kamila
   Lejawa, Mateusz
   Osadnik, Tadeusz
   Golawski, Marcin
   Lewandowski, Piotr
   Pawlas, Natalia
TI "Obesity and Insulin Resistance" Is the Component of the Metabolic
   Syndrome Most Strongly Associated with Oxidative Stress
SO ANTIOXIDANTS
LA English
DT Article
DE oxidative stress; metabolic syndrome; obesity; insulin resistance;
   diabetes; hypertension; dyslipidemia
ID 3RD NATIONAL-HEALTH; PROVISIONAL REPORT; PREVALENCE; ADOLESCENTS;
   MARKERS; PLASMA; DEFINITION; PHENOTYPE; CHILDREN; DAMAGE
AB Metabolic syndrome (MS) is not a homogeneous entity, but this term refers to the coexistence of factors that increase the risk for the development of type 2 diabetes and cardiovascular disease. There are different versions of the criteria for the diagnosis of MS, which makes the population of patients diagnosed with MS heterogeneous. Research to date shows that MS is associated with oxidative stress (OS), but it is unclear which MS component is most strongly associated with OS. The purpose of the study was to investigate the relationship between the parameters of OS and the presence of individual elements of MS in young adults, as well as to identify the components of MS by means of principal components analysis (PCA) and to investigate how the parameters of OS correlate with the presence of individual components. The study included 724 young adults with or without a family history of coronary heart disease (population of the MAGNETIC study). Blood samples were taken from the participants of the study to determine peripheral blood counts, biochemical parameters, and selected parameters of OS. In addition, blood pressure and anthropometric parameters were measured. In subjects with MS, significantly lower activity of superoxide dismutase (SOD), copper- and zinc-containing SOD (CuZnSOD), and manganese-containing SOD (MnSOD) were found, along with significantly higher total antioxidant capacity (TAC) and significantly lower concentration of thiol groups per gram of protein (PSH). We identified three components of MS by means of PCA: "Obesity and insulin resistance", "Dyslipidemia", and "Blood pressure", and showed the component "Obesity and insulin resistance" to have the strongest relationship with OS. In conclusion, we documented significant differences in some parameters of OS between young adults with and without MS. We showed that "Obesity and insulin resistance" is the most important component of MS in terms of relationship with OS.
C1 [Jakubiak, Grzegorz K.; Osadnik, Kamila; Lejawa, Mateusz; Osadnik, Tadeusz; Pawlas, Natalia] Med Univ Silesia, Fac Med Sci Zabrze, Dept Pharmacol, Jordana 38 St, PL-41808 Zabrze, Poland.
   [Jakubiak, Grzegorz K.] Med Univ Silesia, Fac Med Sci Zabrze, Dept & Clin Internal Med Angiol & Phys Med, Batorego 15 St, PL-41902 Bytom, Poland.
   [Golawski, Marcin; Lewandowski, Piotr] Med Univ Silesia, Fac Med Sci Zabrze, Dept Pharmacol, Student Res Grp, Jordana 38 St, PL-41808 Zabrze, Poland.
C3 Medical University of Silesia; Medical University of Silesia; Medical
   University of Silesia
RP Jakubiak, GK (corresponding author), Med Univ Silesia, Fac Med Sci Zabrze, Dept Pharmacol, Jordana 38 St, PL-41808 Zabrze, Poland.; Jakubiak, GK (corresponding author), Med Univ Silesia, Fac Med Sci Zabrze, Dept & Clin Internal Med Angiol & Phys Med, Batorego 15 St, PL-41902 Bytom, Poland.
EM grzegorz.k.jakubiak@gmail.com; kosadnik@sum.edu.pl;
   mateusz.lejawa@sum.edu.pl; tadeusz.osadnik@sum.edu.pl;
   martin.golawski@gmail.com; lewandop@icloud.com;
   natalia.pawlas@sum.edu.pl
RI Lewandowski, Piotr/GQB-1330-2022; Jakubiak, Grzegorz K./ABC-9750-2021;
   Osadnik, Tadeusz/P-5844-2014; Pawlas, Natalia/H-5796-2013
OI Lewandowski, Piotr/0000-0003-4079-3001; Lejawa,
   Mateusz/0000-0002-1228-7534; Osadnik, Tadeusz/0000-0002-3202-6972;
   Pawlas, Natalia/0000-0002-7551-9371; Golawski,
   Marcin/0000-0001-7891-672X; Osadnik, Kamila/0000-0002-4618-9844;
   Jakubiak, Grzegorz K./0000-0003-0039-8306
FU National Science Centre [UMO-2014/13/B/NZ5/03166]; Medical University of
   Silesia [KNW-1-039/N/8/K]
FX The study was financed by the National Science Centre
   (UMO-2014/13/B/NZ5/03166, OPUS 7) and the Medical University of Silesia
   (Grant No. KNW-1-039/N/8/K).
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NR 75
TC 70
Z9 73
U1 1
U2 46
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD JAN
PY 2022
VL 11
IS 1
AR 79
DI 10.3390/antiox11010079
PG 16
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA ZE0QM
UT WOS:000758596800001
PM 35052583
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Rani, M
   Aggarwal, R
   Vohra, K
AF Rani, Monika
   Aggarwal, Rohit
   Vohra, Kanchan
TI Effect of N-Acetylcysteine on Metabolic Profile in Metabolic Syndrome
   Patients
SO METABOLIC SYNDROME AND RELATED DISORDERS
LA English
DT Article
DE oxidative stress; low-grade systemic inflammation; multiple
   pharmacological properties; insulin resistance; endothelial dysfunction;
   metabolic syndrome
ID VITAMIN-D SUPPLEMENTATION; OXIDATIVE STRESS; BLOOD-PRESSURE; INSULIN
   SENSITIVITY; ACETYL-CYSTEINE; RISK-FACTORS; WOMEN; ACTIVATION; METFORMIN
AB Background:N-acetylcysteine (NAC), the acetylated variant of amino acidl-cysteine, acts as a free radical scavenger and plays multifunctional roles by suppressing endogenous level of oxidative stress and inflammation and by enhancing nitric oxide bioavailability. Thus, present study aimed to evaluate the efficacy of NAC on various inherent components of metabolic syndrome (MetS). Methods:An open-label pilot study was conducted at diabetes outpatient clinic. Thirty-five patients (aged >= 18 years) fulfilling the NCEP-ATP III diagnostic criteria for MetS were recruited and allocated to NAC tablets as 600 mg (twice a day) along with their ongoing therapeutic regimen. Blood pressure (BP), body mass index, lipid profile, fasting plasma glucose and insulin, insulin resistance estimated by homeostatic model assessment (HOMA-IR), high-sensitivity C-reactive proteins (hsCRP), nitrite, and thiobarbituric acid reactive substances (TBARS) were measured after 6 weeks treatment. Results:HOMA-IR, hsCRP and systolic BP were decreased significantly from 4.74 +/- 0.30% to 3.86 +/- 0.21%; 5.66 +/- 0.27 to 4.92 +/- 0.18 mg/L; and 133.2 +/- 1.84 to 128.3 +/- 1.52 mmHg, respectively. Among dyslipidemic variables, there was decrease in triglycerides from 194.20 +/- 5.03 to 188.04 +/- 4.93 mg/dL, but increase in HDL from 33.32 +/- 0.19 to 36.29 +/- 1.16 mg/dL. Nitrite levels were significantly increased from 6.25 +/- 0.20 to 7.92 +/- 0.18 mu mol/L (P = 0.04), while TBARS levels were decreased from 14.65 +/- 0.32 to 13.68 +/- 0.33 nmol/L (P = 0.05). It was found from correlation analysis that hsCRP was the main culprit, that is, inflammation was perpetuator of endothelial dysfunction, IR, oxidative stress, hypertension, andvice-versa. Conclusion:This study has provided a new approach of management of MetS with NAC beyond controlling the disease with various drug therapies. NAC may reduce the risk burden via multiple antioxidant, anti-inflammatory, and vasodilatory effect.
C1 [Rani, Monika; Vohra, Kanchan] Punjabi Univ, Dept Pharmaceut Sci & Drug Res, Pharm Practice, Patiala, Punjab, India.
   [Aggarwal, Rohit] Aggarwal Hlth Care, Endocrinol, Patiala, Punjab, India.
C3 Punjabi University
RP Vohra, K (corresponding author), Punjabi Univ, Dept Pharmaceut Sci & Drug Res, Patiala 147002, Punjab, India.
EM kanchan_vohra23@yahoo.com
FU NIL (the academic institute Punjabi University, Patiala, Punjab)
FX NIL (the academic institute Punjabi University, Patiala, Punjab provided
   the candidate all the financial support for carrying the research work).
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NR 35
TC 12
Z9 12
U1 0
U2 1
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-4196
EI 1557-8518
J9 METAB SYNDR RELAT D
JI Metab. Syndr. Relat. Disord.
PD SEP 1
PY 2020
VL 18
IS 7
BP 341
EP 346
DI 10.1089/met.2020.0017
EA JUN 2020
PG 6
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA NO2MD
UT WOS:000541948800001
PM 32552298
DA 2025-06-11
ER

PT J
AU Mutruc, V
   Bologa, C
   Sorodoc, V
   Ceasovschih, A
   Morarasu, BC
   Sorodoc, L
   Catar, OE
   Lionte, C
AF Mutruc, Victoria
   Bologa, Cristina
   Sorodoc, Victorita
   Ceasovschih, Alexandr
   Morarasu, Bianca Codrina
   Sorodoc, Laurentiu
   Catar, Oana Elena
   Lionte, Catalina
TI Cardiovascular-Kidney-Metabolic Syndrome: A New Paradigm in Clinical
   Medicine or Going Back to Basics?
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Review
DE hypertension; chronic kidney disease; diabetes; metabolic syndrome;
   obesity; heart failure; cardiovascular-kidney-metabolic syndrome
ID HEART-FAILURE; AMERICAN-COLLEGE; SCIENTIFIC STATEMENT; PRACTICE
   GUIDELINES; RISK PREDICTION; OBESITY; DISEASE; MANAGEMENT; ASSOCIATION;
   ADULTS
AB Cardiovascular, renal, and metabolic diseases are pathophysiologically interdependent, posing a significant global health challenge and being associated with a substantial increase in morbidity and mortality. In 2023, the American Heart Association (AHA) defined this complex network of interconnected health conditions as the cardiovascular-kidney-metabolic (CKM) syndrome. This syndrome is based on common pathophysiological mechanisms, including chronic inflammation, oxidative stress, hyperglycemia and insulin resistance, activation of the renin-angiotensin-aldosterone system (RAAS), and neurohormonal dysfunction, which trigger a vicious cycle where the impairment of one organ contributes to the progressive deterioration of the others. An integrated approach to these conditions, rather than treating them as separate entities, supports a holistic management strategy that helps to reduce the burden on public health and improve patients' quality of life. Existing management focuses on lifestyle modification, glycemic and lipid control, and the use of nephroprotective and cardioprotective therapies. This narrative review aims to synthesize and contextualize existing information on the complex interactions between these systems and on diagnostic approaches, as well as to provide an overview of the available therapeutic options.
C1 [Mutruc, Victoria; Bologa, Cristina; Sorodoc, Victorita; Ceasovschih, Alexandr; Morarasu, Bianca Codrina; Sorodoc, Laurentiu; Lionte, Catalina] Grigore T Popa Univ Med & Pharm, Fac Med, Iasi 700115, Romania.
   [Mutruc, Victoria; Bologa, Cristina; Sorodoc, Victorita; Ceasovschih, Alexandr; Morarasu, Bianca Codrina; Sorodoc, Laurentiu; Lionte, Catalina] Sf Spiridon Clin Emergency Hosp, Internal Med Dept 2, Iasi 700111, Romania.
   [Catar, Oana Elena] Ctr Hosp Univ Angers, Dept Neurol, F-49933 Angers 9, France.
C3 Grigore T Popa University of Medicine & Pharmacy; Universite d'Angers;
   Centre Hospitalier Universitaire d'Angers
RP Mutruc, V; Lionte, C (corresponding author), Grigore T Popa Univ Med & Pharm, Fac Med, Iasi 700115, Romania.; Mutruc, V; Lionte, C (corresponding author), Sf Spiridon Clin Emergency Hosp, Internal Med Dept 2, Iasi 700111, Romania.
EM victoria.mutruc@yahoo.com; cristina.bologa@umfiasi.ro;
   victorita.sorodoc@umfiasi.ro; alexandr.ceasovschih@umfiasi.ro;
   morarasu.bianca.codrina@gmail.com; laurentiu.sorodoc@umfiasi.ro;
   oanaelena.catar@chu-angers.fr; catalina.lionte@umfiasi.ro
RI Morarasu, Bianca-Codrina/GXN-0229-2022; Ceasovschih,
   Alexandr/AAF-2773-2021; Șorodoc, Laurențiu/GZM-0059-2022; VICTORITA,
   SORODOC/AGH-5818-2022; Cristina, Bologa/KWU-8665-2024; LIONTE,
   CATALINA/A-5283-2013
OI LIONTE, CATALINA/0000-0002-0525-0645; Ceasovschih,
   Alexandr/0000-0002-0043-9051
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NR 137
TC 0
Z9 0
U1 2
U2 2
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD APR 19
PY 2025
VL 14
IS 8
AR 2833
DI 10.3390/jcm14082833
PG 28
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 1WV1W
UT WOS:001475534200001
PM 40283662
DA 2025-06-11
ER

PT J
AU Marjani, A
   Sajedi, A
AF Marjani, Abdoljalal
   Sajedi, Atefe
TI Age and gender related paraoxonase I gene polymorphisms rs662 and
   rs854560 and serum activity in subjects with metabolic syndrome in Fars
   ethnic group
SO JOURNAL OF KRISHNA INSTITUTE OF MEDICAL SCIENCES UNIVERSITY
LA English
DT Article
DE Gender; Paraoxonase I; Metabolic Syndrome; Fars; Age
ID OXIDATIVE STRESS; PON1; DISEASE; RISK; PREVALENCE; PHENOTYPES; ADULTS
AB Background: The prevalence of Metabolic Syndrome (MetS) is different among different populations. The human Paraoxonase (PON) genes have been less reported in the literature. So it is a need of hour to study PON. Aim and Objectives: To determine the Paraoxonase I (PON1) gene polymorphisms and its paraoxonase activity in subjects with were done using Polymerase Chain Reaction (PCR) and Restriction Fragment Length Polymorphism (RFLP) analysis. Results: The MM, LM, and LL genotype frequencies of the PON1- L55M polymorphism were 2.5, 37.5 and 60%; and 27.6, 34.5 and 37.9% and; 19.4, 50 and 30.6% and 17.2, 58.6 and 34.2% in females and males with and without MetS, respectively. Females with L allele of L55M polymorphism had a nearly 14.86 -fold risk of developing MetS. Conclusion: Our study suggested that the decrease of PON1 enzymatic activity in both genders is an important finding, but the L55M genotype and L allele in females with MetS are more important risk factors of MetS than PON1 Q192R polymorphism. This difference in L55M among females may make them more vulnerable than males to MetS.
C1 [Marjani, Abdoljalal; Sajedi, Atefe] Golestan Univ Med Sci, Gorgan Fac Med, Metab Disorders Res Ctr, Dept Biochem & Biophys, Gorgan, Golestan Provin, Iran.
   [Marjani, Abdoljalal] Golestan Univ Med Sci, Fac Med, Metab Disorders Res Ctr, Dept Biochem & Biophys, Gorgan, Golestan Provin, Iran.
C3 Golestan University of Medical Sciences; Golestan University of Medical
   Sciences
RP Marjani, A (corresponding author), Golestan Univ Med Sci, Fac Med, Metab Disorders Res Ctr, Dept Biochem & Biophys, Gorgan, Golestan Provin, Iran.
EM drmarjani@goums.ac.ir
RI Marjani, Abdol/P-8976-2017
FU Research Deputy of Golestan University of Medical Science
FX This work has been supported by Research Deputy of Golestan University
   of Medical Science.
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NR 30
TC 1
Z9 1
U1 0
U2 0
PU KRISHNA INST MEDICAL SCIENCES UNIV
PI MAHARASHTRA
PA MALKAPUR, KARAD, MAHARASHTRA, 415 539, INDIA
SN 2231-4261
J9 J KRISHNA INST MED S
JI J. Krishna Inst. Med. Sci. Univ.
PD OCT-DEC
PY 2023
VL 12
IS 4
BP 68
EP 80
PG 13
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA IN8L4
UT WOS:001167097700015
DA 2025-06-11
ER

PT J
AU Katsi, V
   Papakonstantinou, I
   Tsioufis, K
AF Katsi, Vasiliki
   Papakonstantinou, Ilias
   Tsioufis, Konstantinos
TI Atherosclerosis, Diabetes Mellitus, and Cancer: Common Epidemiology,
   Shared Mechanisms, and Future Management
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE lipoprotein metabolism; cancer metabolism; endothelial dysfunction;
   metabolic syndrome; oxidized lipids; oncogenic signals; autophagy;
   oxidative stress; adiposity; glycation; atherosclerosis
ID GLYCATION END-PRODUCTS; FATTY-ACID SYNTHASE; TOLL-LIKE RECEPTORS;
   ENDOTHELIAL GROWTH-FACTOR; HYPOXIA-INDUCIBLE FACTOR; LIVER X RECEPTORS;
   LIPID-METABOLISM; CARDIOVASCULAR-DISEASE; SIGNALING PATHWAYS; TUMOR
   ANGIOGENESIS
AB The involvement of cardiovascular disease in cancer onset and development represents a contemporary interest in basic science. It has been recognized, from the most recent research, that metabolic syndrome-related conditions, ranging from atherosclerosis to diabetes, elicit many pathways regulating lipid metabolism and lipid signaling that are also linked to the same framework of multiple potential mechanisms for inducing cancer. Otherwise, dyslipidemia and endothelial cell dysfunction in atherosclerosis may present common or even interdependent changes, similar to oncogenic molecules elevated in many forms of cancer. However, whether endothelial cell dysfunction in atherosclerotic disease provides signals that promote the pre-clinical onset and proliferation of malignant cells is an issue that requires further understanding, even though more questions are presented with every answer. Here, we highlight the molecular mechanisms that point to a causal link between lipid metabolism and glucose homeostasis in metabolic syndrome-related atherosclerotic disease with the development of cancer. The knowledge of these breakthrough mechanisms may pave the way for the application of new therapeutic targets and for implementing interventions in clinical practice.
C1 [Katsi, Vasiliki; Tsioufis, Konstantinos] Hippokrateion Hosp, Dept Cardiol, Athens 11527, Greece.
   [Papakonstantinou, Ilias] Evangelismos Med Ctr, Dept Internal Med 4, Athens 10676, Greece.
   [Tsioufis, Konstantinos] Natl & Kapodistrian Univ Athens, Sch Med, Athens 11527, Greece.
C3 Hippokration General Hospital; Evangelismos Hospital; National &
   Kapodistrian University of Athens; Athens Medical School
RP Katsi, V (corresponding author), Hippokrateion Hosp, Dept Cardiol, Athens 11527, Greece.
EM vkkatsi@yahoo.gr; iliaspapacon@yahoo.gr; ktsioufis@gmail.com
RI Papakonstantinou, Ilias/AAC-5703-2022
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NR 352
TC 14
Z9 14
U1 2
U2 12
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD JUL
PY 2023
VL 24
IS 14
AR 11786
DI 10.3390/ijms241411786
PG 41
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA N3FN5
UT WOS:001035913300001
PM 37511551
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Ntamo, Y
   Jack, B
   Ziqubu, K
   Mazibuko-Mbeje, SE
   Nkambule, BB
   Nyambuya, TM
   Mabhida, SE
   Hanser, S
   Orlando, P
   Tiano, L
   Dludla, P
AF Ntamo, Yonela
   Jack, Babalwa
   Ziqubu, Khanyisani
   Mazibuko-Mbeje, Sithandiwe E.
   Nkambule, Bongani B.
   Nyambuya, Tawanda M.
   Mabhida, Sihle E.
   Hanser, Sidney
   Orlando, Patrick
   Tiano, Luca
   Dludla, Phiwayinkosi, V
TI Epigallocatechin gallate as a nutraceutical to potentially target the
   metabolic syndrome: novel insights into therapeutic effects beyond its
   antioxidant and anti-inflammatory properties
SO CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
LA English
DT Review
DE Antioxidants; epigallocatechin gallate; green tea; inflammation;
   metabolic syndrome; nutraceuticals
ID GREEN TEA EXTRACT; CATECHOL-O-METHYLTRANSFERASE; RISK-FACTORS;
   POLYPHENOL EPIGALLOCATECHIN-3-GALLATE; (-)-EPIGALLOCATECHIN GALLATE;
   INSULIN-RESISTANCE; HYDROGEN-PEROXIDE; OXIDATIVE STRESS; FAT OXIDATION;
   DOUBLE-BLIND
AB Epigallocatechin gallate (EGCG) is one of the most abundant and powerful flavonoids contained in green tea. Because of the global increase in green tea consumption, there has been a general interest in understanding its health benefits, including its bioactive compounds like EGCG. Indeed, preclinical evidence already indicates that EGCG demonstrated a strong antioxidant and anti-inflammatory properties that could be essential in protecting against metabolic syndrome. The current review explores clinical evidence reporting on the beneficial effects of EGCG supplementation in obese subjects or patients with diverse metabolic complications that include type 2 diabetes and cardiovascular disease. The discussion incorporates the impact of different formulations of EGCG, as well as the effective doses and treatment duration. Importantly, besides highlighting the potential use of EGCG as a nutraceutical, the current review also discusses crucial evidence related to its pharmaceutical development as an agent to hinder metabolic diseases, including its bioavailability and metabolism profile, as well as its well-known biological properties.
C1 [Ntamo, Yonela; Jack, Babalwa; Mabhida, Sihle E.; Dludla, Phiwayinkosi, V] South African Med Res Council, Biomed Res & Innovat Platform, Tygerberg, South Africa.
   [Ziqubu, Khanyisani; Mazibuko-Mbeje, Sithandiwe E.] North West Univ, Dept Biochem, Mmabatho, South Africa.
   [Nkambule, Bongani B.] Univ KwaZulu Natal, Sch Lab Med & Med Sci, Durban, South Africa.
   [Nyambuya, Tawanda M.] Namibia Univ Sci & Technol, Dept Hlth Sci, Windhoek, Namibia.
   [Hanser, Sidney] Univ Limpopo, Dept Physiol & Environm Hlth, Sovenga, South Africa.
   [Orlando, Patrick; Tiano, Luca] Polytech Univ Marche, Dept Life & Environm Sci, Ancona, Italy.
   [Dludla, Phiwayinkosi, V] Univ Zululand, Dept Biochem & Microbiol, Kwa Dlangezwa, South Africa.
C3 South African Medical Research Council; North West University - South
   Africa; University of Kwazulu Natal; Namibia University of Science &
   Technology; University of Limpopo; Marche Polytechnic University;
   University of Zululand
RP Dludla, P (corresponding author), South African Med Res Council, Biomed Res & Innovat Platform, Tygerberg, South Africa.; Dludla, P (corresponding author), Univ Zululand, Dept Biochem & Microbiol, Kwa Dlangezwa, South Africa.
RI Mazibuko-Mbeje, Sithandiwe/HPG-1119-2023; Nkambule,
   Bongani/ABD-7943-2022; Orlando, Patrick/LSJ-0851-2024; Nyambuya, Tawanda
   Maurice/GLU-4124-2022; Jack, Babalwa/LTF-1602-2024; Tiano,
   Luca/ABC-2341-2020
OI Nyambuya, Tawanda Maurice/0000-0002-3288-9524; Ziqubu,
   Khanyisani/0000-0002-1211-9688; Tiano, Luca/0000-0002-7519-7106;
   Mabhida, Sihle/0000-0002-8388-132X; Orlando,
   Patrick/0000-0002-4203-9611; Nkambule, Bongani/0000-0001-8846-1992;
   Hanser, Sidney/0000-0002-6719-8512
FU Biomedical Research and Innovation Platform of the South African Medical
   Research Council (SAMRC); National Research Foundation (NRF) of South
   Africa [117829]
FX This work was supported in part by baseline funding from the Biomedical
   Research and Innovation Platform of the South African Medical Research
   Council (SAMRC) and the National Research Foundation (NRF) of South
   Africa (Grant number: 117829). The content hereof is the sole
   responsibility of the authors and do not necessarily represent the
   official views of the SAMRC or the funders.
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NR 196
TC 30
Z9 30
U1 2
U2 45
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1040-8398
EI 1549-7852
J9 CRIT REV FOOD SCI
JI Crit. Rev. Food Sci. Nutr.
PD JAN 2
PY 2024
VL 64
IS 1
BP 87
EP 109
DI 10.1080/10408398.2022.2104805
EA JUL 2022
PG 23
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA DS6Q3
UT WOS:000835221400001
PM 35916835
DA 2025-06-11
ER

PT J
AU Pravenec, M
   Kajiya, T
   Zídek, V
   Landa, V
   Mlejnek, P
   Simáková, M
   Silhavy, J
   Malínská, H
   Oliyarnyk, O
   Kazdová, L
   Fan, JL
   Wang, JM
   Kurtz, TW
AF Pravenec, Michal
   Kajiya, Takashi
   Zidek, Vaclav
   Landa, Vladimir
   Mlejnek, Petr
   Simakova, Miroslava
   Silhavy, Jan
   Malinska, Hana
   Oliyarnyk, Olena
   Kazdova, Ludmila
   Fan, Jianglin
   Wang, Jiaming
   Kurtz, Theodore W.
TI Effects of Human C-Reactive Protein on Pathogenesis of Features of the
   Metabolic Syndrome
SO HYPERTENSION
LA English
DT Article
DE C-reactive protein; metabolic syndrome; oxidative stress; transgenic;
   spontaneously hypertensive rat
ID ENDOTHELIAL DYSFUNCTION; CARDIOVASCULAR-DISEASE; IN-VIVO; MICE;
   ATHEROTHROMBOSIS; ATHEROGENESIS; HYPERTENSION; INFLAMMATION; RATS
AB Major controversy exists as to whether increased C-reactive protein (CRP) contributes to individual components of the metabolic syndrome or is just a secondary response to inflammatory disease processes. We measured blood pressure and metabolic phenotypes in spontaneously hypertensive rats (SHRs) in which we transgenically expressed human CRP in the liver under control of the apolipoprotein E promoter. In transgenic SHRs, serum levels of human CRP approximated the endogenous levels of CRP normally found in the rat. Systolic and diastolic blood pressures measured by telemetry were 10 to 15 mm Hg greater in transgenic SHRs expressing human CRP than in SHR controls (P<0.01). During oral glucose tolerance testing, transgenic SHRs exhibited hyperinsulinemia compared with controls (insulin area under the curve: 36 +/- 7 versus 8 +/- 2 nmol/L per 2 hours, respectively; P<0.05). Transgenic SHRs also exhibited resistance to insulin stimulated glycogenesis in skeletal muscle (174 +/- 18 versus 278 +/- 32 nmol of glucose per gram per 2 hours; P<0.05), hypertriglyceridemia (0.84 +/- 0.05 versus 0.64 +/- 0.03 mmol/L; P<0.05), reduced serum adiponectin (2.4 +/- 0.3 versus 4.3 +/- 0.6 mmol/L; P<0.05), and microalbuminuria (200 +/- 35 versus 26 +/- 5 mg of albumin per gram of creatinine, respectively; P<0.001). Transgenic SHRs had evidence of inflammation and oxidative tissue damage with increased serum levels of interleukin 6 (36.4 +/- 5.2 versus 18 +/- 1.7 pg/mL; P<0.005) and increased hepatic and renal thiobarbituric acid reactive substances (1.2 +/- 0.09 versus 0.8 +/- 0.07 and 1.5 +/- 0.1 versus 1.1 +/- 0.05 nmol/L per milligram of protein, respectively; P<0.01), suggesting that oxidative stress may be mediating adverse effects of increased human CRP. These findings are consistent with the hypothesis that increased CRP is more than just a marker of inflammation and can directly promote multiple features of the metabolic syndrome. (Hypertension. 2011;57:731-737.)
C1 [Pravenec, Michal; Zidek, Vaclav; Landa, Vladimir; Mlejnek, Petr; Simakova, Miroslava; Silhavy, Jan] Acad Sci Czech Republic, Inst Physiol, CR-14220 Prague 4, Czech Republic.
   [Kajiya, Takashi; Wang, Jiaming; Kurtz, Theodore W.] Univ Calif San Francisco, Dept Lab Med, San Francisco, CA 94143 USA.
   [Silhavy, Jan] Czech Univ Life Sci, Fac Agr Food & Nat Resources, Prague, Czech Republic.
   [Malinska, Hana; Oliyarnyk, Olena; Kazdova, Ludmila] Inst Clin & Expt Med, Prague, Czech Republic.
   [Fan, Jianglin] Univ Yamanashi, Dept Mol Pathol, Yamanashi, Japan.
C3 Czech Academy of Sciences; Institute of Physiology of the Czech Academy
   of Sciences; University of California System; University of California
   San Francisco; Czech University of Life Sciences Prague; Institute for
   Clinical & Experimental Medicine (IKEM); University of Yamanashi
RP Pravenec, M (corresponding author), Acad Sci Czech Republic, Inst Physiol, Videnska 1083, CR-14220 Prague 4, Czech Republic.
EM pravenec@biomed.cas.cz
RI Zidek, Vaclav/C-6685-2012; Oliyarnyk, Olena/Q-6380-2019; Silhavy,
   Jan/B-5292-2014; Simakova, Miroslava/R-5367-2019; Landa,
   Vladimir/B-8908-2012; Pravenec, Michal/B-1666-2012; Mlejnek,
   Petr/C-2305-2012
OI Pravenec, Michal/0000-0001-9197-5871; Fan, Jianglin/0000-0002-1737-6130;
   Mlejnek, Petr/0000-0002-4218-8983; Oliyarnyk, Olena/0000-0002-4912-6187;
   Simakova, Miroslava/0000-0003-1468-5832
FU Internal Grant Agency of the Ministry of Health of the Czech Republic
   [NS9757-3]; Ministry of Education of the Czech Republic [ME08006,
   1M0520, MSM6046070901]; Grant Agency of the Czech Republic [301/10/0290,
   P303/10/0505]; Grant Agency of the Academy of Sciences of the Czech
   Republic [IAA500110805]; European Community [HEALTH-F4-2010-241504];
   National Heart, Lung, and Blood Institute of the National Institutes of
   Health; Grants-in-Aid for Scientific Research [22390068] Funding Source:
   KAKEN
FX This work was supported by the Internal Grant Agency of the Ministry of
   Health of the Czech Republic (NS9757-3); the Ministry of Education of
   the Czech Republic (ME08006, 1M0520, and MSM6046070901); the Grant
   Agency of the Czech Republic (301/10/0290 and P303/10/0505); Grant
   Agency of the Academy of Sciences of the Czech Republic (IAA500110805);
   the European Community's Seventh Framework Program (FP7/2007-2013) under
   grant agreement HEALTH-F4-2010-241504 (EURATRANS); and the National
   Heart, Lung, and Blood Institute of the National Institutes of Health.
   M. P. is an international research scholar of the Howard Hughes Medical
   Institute.
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NR 31
TC 60
Z9 67
U1 0
U2 9
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0194-911X
J9 HYPERTENSION
JI Hypertension
PD APR
PY 2011
VL 57
IS 4
BP 731
EP +
DI 10.1161/HYPERTENSIONAHA.110.164350
PG 10
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 735RL
UT WOS:000288434600019
PM 21357282
OA Bronze, Green Accepted
DA 2025-06-11
ER

PT J
AU Zhang, TH
   Tang, XC
   Xu, LH
   Wei, YY
   Hu, YG
   Cui, HR
   Tang, YY
   Chen, T
   Li, CB
   Zhou, LL
   Wang, JJ
AF Zhang, Tian Hong
   Tang, Xiao Chen
   Xu, Li Hua
   Wei, Yan Yan
   Hu, Ye Gang
   Cui, Hui Ru
   Tang, Ying Ying
   Chen, Tao
   Li, Chun Bo
   Zhou, Lin Lin
   Wang, Ji Jun
TI Imbalance Model of Heart Rate Variability and Pulse Wave Velocity in
   Psychotic and Nonpsychotic Disorders
SO SCHIZOPHRENIA BULLETIN
LA English
DT Article
DE psychosis; drug-free; parasympathetic; sympathetic nervous system;
   cardiovascular pathology; autonomic imbalance
ID NERVOUS-SYSTEM DYSFUNCTION; LATE-LIFE DEPRESSION; ARTERIAL STIFFNESS;
   METABOLIC SYNDROME; SCHIZOPHRENIA; RISK; BRAIN; POWER; MORTALITY;
   SYMPTOMS
AB Objectives: Patients with psychiatric disorders have an increased risk of cardiovascular pathologies. A bidirectional feedback model between the brain and heart exists widely in both psychotic and nonpsychotic disorders. The aim of this study was to compare heart rate variability (HRV) and pulse wave velocity (PWV) functions between patients with psychotic and nonpsychotic disorders and to investigate whether subgroups defined by HRV and PWV features improve the transdiagnostic psychopathology of psychiatric classification. Methods: In total, 3448 consecutive patients who visited psychiatric or psychological health services with psychotic (N = 1839) and nonpsychotic disorders (N = 1609) and were drug-free for at least 2 weeks were selected. HRV and PWV indicators were measured via finger photoplethysmography during a 5-minute period of rest. Canonical variates were generated through HRV and PWV indicators by canonical correlation analysis (CCA). Results: All HRV indicators but none of the PWV indicators were significantly reduced in the psychotic group relative to those in the nonpsychotic group. After adjusting for age, gender, and body mass index, many indices of HRV were significantly reduced in the psychotic group compared with those in the nonpsychotic group. CCA analysis revealed 2 subgroups defined by distinct and relatively homogeneous patterns along HRV and PWV dimensions and comprising 19.0% (subgroup 1, n = 655) and 80.9% (subgroup 2, n = 2781) of the sample, each with distinctive features of HRV and PWV functions. Conclusions: HRV functions are significantly impaired among psychiatric patients, especially in those with psychosis. Our results highlight important subgroups of psychiatric patients that have distinct features of HRV and PWV which transcend current diagnostic boundaries.
C1 [Zhang, Tian Hong; Tang, Xiao Chen; Xu, Li Hua; Wei, Yan Yan; Hu, Ye Gang; Cui, Hui Ru; Tang, Ying Ying; Li, Chun Bo; Zhou, Lin Lin; Wang, Ji Jun] Shanghai Jiao Tong Univ, Shanghai Mental Hlth Ctr, Shanghai Key Lab Psychot Disorders, Sch Med, Shanghai 200030, Peoples R China.
   [Chen, Tao] Univ Waterloo, Big Data Res Lab, Waterloo, ON, Canada.
   [Chen, Tao] Harvard Univ, Labor & Worklife Program, Boston, MA 02115 USA.
   [Chen, Tao] Niacin Shanghai Technol Co Ltd, Shanghai, Peoples R China.
   [Wang, Ji Jun] Chinese Acad Sci, CAS Ctr Excellence Brain Sci & Intelligence Techn, Shanghai, Peoples R China.
   [Wang, Ji Jun] Shanghai Jiao Tong Univ, Inst Psychol & Behav Sci, Shanghai, Peoples R China.
C3 Shanghai Jiao Tong University; University of Waterloo; Harvard
   University; Chinese Academy of Sciences; Center for Excellence in Brain
   Science and Intelligence Technology, CAS; Shanghai Jiao Tong University
RP Wang, JJ (corresponding author), Shanghai Jiao Tong Univ, Sch Med,Shanghai Mental Hlth Ctr, Shanghai Key Lab Psychot Disorders 13dz2260500,Mi, BioX Inst,Key Lab Genet Dev & Neuropsychiat Disor, 600 Wanping Nan Rd, Shanghai 200030, Peoples R China.
EM jijunwang27@163.com
RI 周, 林/KIH-4929-2024; Wang, Jijun/HTP-0666-2023; Zhang,
   TianHong/IQS-6148-2023; Chen, Jianhua/AAS-8417-2020; Xu,
   Lihua/P-8054-2019
OI hu, yegang/0000-0002-9863-2836
FU Ministry of Science and Technology of China; National Key R&D Program of
   China [2016YFC1306800]; National Natural Science Foundation of China
   [81671329, 81671332]; Science and Technology Commission of Shanghai
   Municipality [19441907800, 17411953100, 19ZR1445200, 19411950800];
   Construction, Shanghai 3-Year Public Health Action Plan [GWV-10.1-XK18];
   Shanghai Clinical Research Center for Mental Health [19MC1911100];
   Clinical Research Center at Shanghai Mental Health Center [CRC2018ZD01,
   CRC2018ZD04, CRC2018YB01, CRC2019ZD02]
FX This study was supported by the Ministry of Science and Technology of
   China, National Key R&D Program of China (2016YFC1306800), National
   Natural Science Foundation of China (81671329 and 81671332), Science and
   Technology Commission of Shanghai Municipality (19441907800,
   17411953100, 19ZR1445200, and 19411950800), Construction, Shanghai
   3-Year Public Health Action Plan (GWV-10.1-XK18), Shanghai Clinical
   Research Center for Mental Health (19MC1911100), and the Clinical
   Research Center at Shanghai Mental Health Center (CRC2018ZD01,
   CRC2018ZD04, CRC2018YB01, and CRC2019ZD02).
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NR 56
TC 9
Z9 9
U1 1
U2 16
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0586-7614
EI 1745-1701
J9 SCHIZOPHRENIA BULL
JI Schizophr. Bull.
PD JAN
PY 2022
VL 48
IS 1
BP 154
EP 165
DI 10.1093/schbul/sbab080
EA JUL 2021
PG 12
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA YL9FY
UT WOS:000746192700019
PM 34313787
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Sokumbi, O
   Hodge, DO
   Ederaine, SA
   Alavi, A
   Alikhan, A
AF Sokumbi, Olayemi
   Hodge, David O.
   Ederaine, Sophia A.
   Alavi, Afsaneh
   Alikhan, Ali
TI Comorbid diseases of Hidradenitis Suppurativa: a 15-Year
   Population-Based study in Olmsted County, Minnesota, USA
SO INTERNATIONAL JOURNAL OF DERMATOLOGY
LA English
DT Article
ID MEDICAL-RECORDS-LINKAGE; POLYCYSTIC-OVARY-SYNDROME; METABOLIC SYNDROME;
   PREVALENCE; HEALTH; SEVERITY; HISTORY; ADULTS; RISK
AB Background Like other chronic, inflammatory skin disorders, hidradenitis suppurativa (HS) is increasingly recognized to be associated with various medical disorders. Objective Using the Rochester Epidemiology Project (REP), we sought to conduct the first American population-based study examining the association between HS and various comorbid conditions. Methods From the REP database, we identified patients diagnosed with HS from 2003 through 2018 who were residents of Olmsted County, Minnesota, USA, along with age- and gender-matched controls. The frequency of a wide variety of comorbid conditions was compared between the groups. Results A total of 1160 patients with HS were identified during the study period. Compared with age- and gender-matched controls, patients with HS had a significantly higher frequency of several medical conditions, including depression, anxiety, hyperlipidemia, acne conglobata, dissecting cellulitis, pilonidal cysts, polycystic ovary syndrome, diabetes, chronic kidney disease, psoriasis, atopic dermatitis, obesity, and disordered substance use, among others. Limitations Our study was limited by its retrospective design. Conclusions Providers caring for patients with HS should consider these results, along with those of similar studies, and obtain a thorough history, comprehensive physical examination, and, potentially, laboratory testing and referral to other specialists.
C1 [Sokumbi, Olayemi] Mayo Clin, Dept Dermatol & Lab Med, 4500 San Pablo Rd, Jacksonville, FL 32224 USA.
   [Hodge, David O.] Mayo Clin, Div Biomed Stat, Dept Quantitat Hlth Sci, Jacksonville, FL 32224 USA.
   [Ederaine, Sophia A.] Mayo Clin, Alix Sch Med, Arizona Campus, Scottsdale, AZ USA.
   [Alavi, Afsaneh] Mayo Clin, Dept Dermatol, Rochester, MN USA.
   [Alikhan, Ali] Sutter Med Fdn, Dept Dermatol, Sacramento, CA USA.
C3 Mayo Clinic; Mayo Clinic; Mayo Clinic; Mayo Clinic Phoenix; Mayo Clinic
RP Sokumbi, O (corresponding author), Mayo Clin, Dept Dermatol & Lab Med, 4500 San Pablo Rd, Jacksonville, FL 32224 USA.
EM sokumbi.olayemi@mayo.edu
FU National Institute on Aging of the National Institutes of Health
   [R01AG034676]
FX This study was made possible using the resources of the Rochester
   Epidemiology Project, which is supported by the National Institute on
   Aging of the National Institutes of Health under Award Number
   R01AG034676. The content is solely the responsibility of the authors and
   does not necessarily represent the official views of the National
   Institutes of Health.
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NR 61
TC 7
Z9 8
U1 2
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0011-9059
EI 1365-4632
J9 INT J DERMATOL
JI Int. J. Dermatol.
PD NOV
PY 2022
VL 61
IS 11
BP 1372
EP 1379
DI 10.1111/ijd.16228
EA APR 2022
PG 8
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 5J0QO
UT WOS:000788656500001
PM 35485975
DA 2025-06-11
ER

PT J
AU Gabrielsen, JS
   Gao, Y
   Simcox, JA
   Huang, JY
   Thorup, D
   Jones, D
   Cooksey, RC
   Gabrielsen, D
   Adams, TD
   Hunt, SC
   Hopkins, PN
   Cefalu, WT
   McClain, DA
AF Gabrielsen, J. Scott
   Gao, Yan
   Simcox, Judith A.
   Huang, Jingyu
   Thorup, David
   Jones, Deborah
   Cooksey, Robert C.
   Gabrielsen, David
   Adams, Ted D.
   Hunt, Steven C.
   Hopkins, Paul N.
   Cefalu, William T.
   McClain, Donald A.
TI Adipocyte iron regulates adiponectin and insulin sensitivity
SO JOURNAL OF CLINICAL INVESTIGATION
LA English
DT Article
ID SERUM FERRITIN CONCENTRATION; TRANSCRIPTION FACTOR FOXO1; BETA-CELL
   FUNCTION; HEREDITARY HEMOCHROMATOSIS; METABOLIC SYNDROME;
   DIABETES-MELLITUS; OXIDATIVE STRESS; MOUSE MODEL;
   SACCHAROMYCES-CEREVISIAE; TRANSFERRIN RECEPTORS
AB Iron overload is associated with increased diabetes risk. We therefore investigated the effect of iron on adiponectin, an insulin-sensitizing adipokine that is decreased in diabetic patients. In humans, normal-range serum ferritin levels were inversely associated with adiponectin, independent of inflammation. Ferritin was increased and adiponectin was decreased in type 2 diabetic and in obese diabetic subjects compared with those in equally obese individuals without metabolic syndrome. Mice fed a high-iron diet and cultured adipocytes treated with iron exhibited decreased adiponectin mRNA and protein. We found that iron negatively regulated adiponectin transcription via FOXO1-mediated repression. Further, loss of the adipocyte iron export channel, ferroportin, in mice resulted in adipocyte iron loading, decreased adiponectin, and insulin resistance. Conversely, organismal iron overload and increased adipocyte ferroportin expression because of hemochromatosis are associated with decreased adipocyte iron, increased adiponectin, improved glucose tolerance, and increased insulin sensitivity. Phlebotomy of humans with impaired glucose tolerance and ferritin values in the highest quartile of normal increased adiponectin and improved glucose tolerance. These findings demonstrate a causal role for iron as a risk factor for metabolic syndrome and a role for adipocytes in modulating metabolism through adiponectin in response to iron stores.
C1 [Adams, Ted D.; Hunt, Steven C.; Hopkins, Paul N.] Univ Utah, Sch Med, Dept Med, Div Cardiovasc Genet, Salt Lake City, UT USA.
   [Gabrielsen, J. Scott; Gao, Yan; Simcox, Judith A.; Huang, Jingyu; Thorup, David; Jones, Deborah; Cooksey, Robert C.; Gabrielsen, David; McClain, Donald A.] Univ Utah, Sch Med, Dept Biochem, Salt Lake City, UT USA.
   [Cooksey, Robert C.; McClain, Donald A.] VA Med Ctr, Res Serv, Salt Lake City, UT USA.
   [Cefalu, William T.] Louisiana State Univ Syst, Pennington Biomed Res Ctr, Baton Rouge, LA USA.
C3 Utah System of Higher Education; University of Utah; Utah System of
   Higher Education; University of Utah; Louisiana State University System;
   Louisiana State University; Pennington Biomedical Research Center
RP McClain, DA (corresponding author), Div Endocrinol, 30 North,2030 East, Salt Lake City, UT 84132 USA.
EM donald.mcclain@hsc.utah.edu
RI Hsia, Daniel/AAJ-6247-2020; Gabrielsen, Joseph/HJY-5745-2023
OI Simcox, Judith/0000-0001-7350-6342; McClain, Don/0000-0002-3310-2359
FU Research Service of the Veterans Administration; NIH [DK59512,
   5-T32-DK-007115]; University of Utah Clinical and Translational Science
   Award; National Center for Advancing Translational Sciences
   [UL1RR025764]
FX This work was supported by the Research Service of the Veterans
   Administration and NIH grants DK59512 and 5-T32-DK-007115 and the
   University of Utah Clinical and Translational Science Award funded by
   the National Center for Advancing Translational Sciences (UL1RR025764).
   We would like to thank Tom Greene (UL1 RR025764) for help with the
   statistical analysis of our data and also to acknowledge the assistance
   of the Clinical Services, Technology, and Biostatistics and Study Design
   Cores of the CTSA. Mice used in the study were supplied by Nancy Andrews
   (Duke University) and Phillip Scherer (University of Texas
   Southwestern).
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NR 83
TC 242
Z9 262
U1 0
U2 32
PU AMER SOC CLINICAL INVESTIGATION INC
PI ANN ARBOR
PA 2015 MANCHESTER RD, ANN ARBOR, MI 48104 USA
SN 0021-9738
EI 1558-8238
J9 J CLIN INVEST
JI J. Clin. Invest.
PD OCT
PY 2012
VL 122
IS 10
BP 3529
EP 3540
DI 10.1172/JCI44421
PG 12
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 013VK
UT WOS:000309333800024
PM 22996660
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Andersen, CJ
   Fernandez, ML
AF Andersen, Catherine J.
   Fernandez, Maria Luz
TI Dietary strategies to reduce metabolic syndrome
SO REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
LA English
DT Article
DE Metabolic syndrome; Dyslipidemia; Insulin resistance; Inflammation;
   Energy restriction; Carbohydrate-restricted diets; Fatty acids;
   Functional foods; Mediterranean diet
ID HIGH-FAT DIET; CARDIOVASCULAR RISK PROFILE; DAIRY PRODUCT CONSUMPTION;
   LOW-DENSITY-LIPOPROTEIN; INSULIN-RESISTANT MEN; WEIGHT-LOSS;
   MEDITERRANEAN DIET; ALCOHOL-CONSUMPTION; ADIPOSE-TISSUE; CARBOHYDRATE
   RESTRICTION
AB Metabolic syndrome (MetS) is a cluster of metabolic abnormalities characterized by central obesity, dyslipidemias, hypertension, high fasting glucose, chronic low-grade inflammation and oxidative stress. This condition has become an increasing problem in our society where about 34 % of adults are diagnosed with MetS. In parallel with the adult situation, a significant number of children present lipid abnormalities and insulin resistance, which can be used as markers of MetS in the pediatric population. Changes in lifestyle including healthy dietary regimens and increased physical activity should be the first lines of therapy to decrease MetS. In this article, we present the most recent information on successful dietary modifications that can reduce the parameters associated with MetS. Successful dietary strategies include energy restriction and weight loss, manipulation of dietary macronutrients-either through restriction of carbohydrates, fat, or enrichment in beneficial fatty acids, incorporation of functional foods and bioactive nutrients, and adherence to dietary and lifestyle patterns such the Mediterranean diet and diet/exercise regimens. Together, the recent findings presented in this review serve as evidence to support the therapeutic treatment of MetS through diet.
C1 [Andersen, Catherine J.; Fernandez, Maria Luz] Univ Connecticut, Dept Nutr Sci, Storrs, CT 06269 USA.
C3 University of Connecticut
RP Fernandez, ML (corresponding author), Univ Connecticut, Dept Nutr Sci, 3624 Horsebarn Rd Ext,Unit 4017, Storrs, CT 06269 USA.
EM maria-luz.fernandez@uconn.edu
OI Andersen, Catherine/0000-0001-9774-5030
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NR 136
TC 111
Z9 127
U1 0
U2 74
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1389-9155
EI 1573-2606
J9 REV ENDOCR METAB DIS
JI Rev. Endocr. Metab. Disord.
PD SEP
PY 2013
VL 14
IS 3
BP 241
EP 254
DI 10.1007/s11154-013-9251-y
PG 14
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 224JP
UT WOS:000324881200004
PM 23943309
DA 2025-06-11
ER

PT J
AU Nehmi, V
   de Freitas, JA
   Franco, LAM
   Fonseca, JVD
   Martins, RCR
   Santamarina, AB
   Murata, GM
   Sabino, EC
   Souza, E
   Ferreira, MT
   Otoch, JP
   Pessoa, AFM
AF Nehmi-Filho, Victor
   de Freitas, Jessica Alves
   Franco, Lucas Augusto Moyses
   Fonseca, Joyce Vanessa da Silva
   Martins, Roberta Cristina Ruedas
   Santamarina, Aline Boveto
   Murata, Gilson Masahiro
   Sabino, Ester Cerdeira
   Souza, Erica
   Ferreira, Matthew Thomas
   Otoch, Jose Pinhata
   Pessoa, Ana Flavia Marcal
TI Novel Nutraceutical (silymarin, yeast β-glucan, prebiotics, and
   minerals) shifts gut microbiota and restores large intestine histology
   of diet-induced metabolic syndrome mice
SO JOURNAL OF FUNCTIONAL FOODS
LA English
DT Article
DE Nutraceutical; Gut; Microbiota; Silymarin; Prebiotics; Metabolic
   syndrome
ID OBESITY; BENEFITS; HEALTH; MUCINS
AB Gut dysbiosis contributes to chronic inflammation and oxidative stress associated with metabolic syndrome, and non-pharmacological, health-promoting supplements like nutraceuticals have been studied and used as a way to prevent or treat several illnesses. Thus, male C57BL/6 mice were divided into the following groups: control (CTL) _Vehicle and CTL_Nutraceutical; high-fat diet (HFD)_Vehicle, HFD_Nutraceutical, HFD_Nutraceutical_S, and isolated compounds. The vehicle and experimental formulations were administered by gavage once a day for four weeks with a high-fat diet simultaneously. In addition, we evaluated the composition of the fecal microbiota by partial 16S rRNA sequences directly amplified using a bacterial/archaeal primer set 515F/806R, and large intestine histomorphology was examined by H & E (Hematoxylin and Eosin), Masson's trichrome (MT), and PAS-AB (Periodic Acid Schiff-Alcian Blue) stains in these groups of mice. After four weeks of supplementation, only the Novel Nutraceutical supplement was able to increase & alpha; and & beta;-diversities, modulate the relative abundance in gut microbiota, decrease Firmicutes, and increase Bacteroidetes bacteria, meanwhile recovering the large intestine's (colon) histomorphology in CTL and HFD groups.
C1 [Nehmi-Filho, Victor; de Freitas, Jessica Alves; Santamarina, Aline Boveto; Otoch, Jose Pinhata; Pessoa, Ana Flavia Marcal] Univ Sao Paulo, Dept Surg, Med Sch, Nat Prod & Derivat Lab LIM 26, Sao Paulo, SP, Brazil.
   [Nehmi-Filho, Victor; de Freitas, Jessica Alves; Otoch, Jose Pinhata; Pessoa, Ana Flavia Marcal] Efeom Nutr S A, Res & Dev, Sao Paulo, SP, Brazil.
   [Franco, Lucas Augusto Moyses; Martins, Roberta Cristina Ruedas; Sabino, Ester Cerdeira] Univ Sao Paulo, Med Sch, Med Parasitol Lab LIM 46, Inst Trop Med,Dept Infect & Parasit Dis, Sao Paulo, SP, Brazil.
   [Fonseca, Joyce Vanessa da Silva] Univ Sao Paulo, Med Sch, Med Res Lab Bacteriol & Antimicrobial Resistance L, Dept Infect & Parasit Dis,Inst Trop Med, Sao Paulo, SP, Brazil.
   [Murata, Gilson Masahiro] Univ Sao Paulo, Med Sch, Clin Med Dept, Lab Med Invest LIM 29, Sao Paulo, SP, Brazil.
   [Souza, Erica] Monte Azul Ambulatorio, Sao Paulo, SP, Brazil.
   [Ferreira, Matthew Thomas] Hosp Clin Univ Sao Paulo, Med Sch, Ctr Translat Res Oncol, Inst Canc Estado Sao Paulo ICESP, Sao Paulo, SP, Brazil.
   [Pessoa, Ana Flavia Marcal] Nat Prod Comm, Brazilian Acad Consortium Integrat Hlth CABSIN, Sao Paulo, Brazil.
C3 Universidade de Sao Paulo; Universidade de Sao Paulo; Universidade de
   Sao Paulo; Universidade de Sao Paulo; Universidade de Sao Paulo
RP Pessoa, AFM (corresponding author), Univ Sao Paulo, Dept Surg, Med Sch, Nat Prod & Derivat Lab LIM 26, Sao Paulo, SP, Brazil.; Pessoa, AFM (corresponding author), Efeom Nutr S A, Res & Dev, Sao Paulo, SP, Brazil.; Pessoa, AFM (corresponding author), Nat Prod Comm, Brazilian Acad Consortium Integrat Hlth CABSIN, Sao Paulo, Brazil.
EM victor@nehmi.com.br; jessicaalvesdefreitas@gmail.com;
   lucasamfranco@hotmail.com; joycevanesf@gmail.com;
   betacristina@gmail.com; ana.pessoa@fm.usp.br; gilson.murata@usp.br;
   sabinoec@gmail.com; net.erica@gmail.com; matthew.t.ferreira@gmail.com;
   pinhata@usp.br; ana.pessoa@fm.usp.br
RI Ferreira, Matthew/ABE-8683-2020; Pessoa, Ana Flavia/P-7501-2018; Murata,
   Gilson Masahiro/E-4569-2015; Santamarina, Aline/AAI-7639-2020; Sabino,
   Ester/F-7750-2010
FU Efeom Nutrition S.A. [01/04-21]
FX Funding This study was financed by Efeom Nutrition S.A. (01/04-21) .
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NR 93
TC 9
Z9 9
U1 0
U2 15
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1756-4646
EI 2214-9414
J9 J FUNCT FOODS
JI J. Funct. Food.
PD AUG
PY 2023
VL 107
AR 105671
DI 10.1016/j.jff.2023.105671
EA JUL 2023
PG 13
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA N0BR4
UT WOS:001033779400001
OA gold
DA 2025-06-11
ER

PT J
AU Hur, J
   Dauch, JR
   Hinder, LM
   Hayes, JM
   Backus, C
   Pennathur, S
   Kretzler, M
   Brosius, FC
   Feldman, EL
AF Hur, Junguk
   Dauch, Jacqueline R.
   Hinder, Lucy M.
   Hayes, John M.
   Backus, Carey
   Pennathur, Subramaniam
   Kretzler, Matthias
   Brosius, Frank C., III
   Feldman, Eva L.
TI The Metabolic Syndrome and Microvascular Complications in a Murine Model
   of Type 2 Diabetes
SO DIABETES
LA English
DT Article
ID DB/DB MOUSE; NEUROPATHY; NERVE; ABNORMALITIES; PIOGLITAZONE;
   LIPOPROTEINS; RECEPTOR; INJURY; VOLUME; RAT
AB To define the components of the metabolic syndrome that contribute to diabetic polyneuropathy (DPN) in type 2 diabetes (mellitus (T2DM), we treated the BKS db/db mouse, an established murine model of T2DM and the metabolic syndrome, with the thiazolidinedione class drug pioglitazone. Pioglitazone treatment of BKS db/db Mice produced a significant Weight gain, restored glycemic Control, and normalized measures of serum oxidative stress and triglycerides but had no effect on LDLs or total Cholesterol. Moreover, although pioglitazone treatment normalized renal function, it had no effect on measures of large myelinated nerve fibers, specifically sural or sciatic nerve conduction velocities, but significantly improved Measures of small unmyelinated nerve fiber architecture and function. Analyses of gene expression arrays of large myelinated sciatic nerves from pioglitazone-treated animals revealed an unanticipated increase in genes related to adipogenesis, adipokine signaling, and lipoprotein signaling, which likely contributed to the blunted therapeutic response. Similar analyses Of dorsal root ganglion neurons revealed a salutary effect of pioglitazone on pathways related to defense and cytokine production. These data suggest differential susceptibility of small and large nerve fibers to specific metabolic impairments associated with T2DM and provide the basis for discussion of new treatment paradigms for individuals with T2DM and DPN.
C1 [Hur, Junguk; Dauch, Jacqueline R.; Hinder, Lucy M.; Hayes, John M.; Backus, Carey; Feldman, Eva L.] Univ Michigan, Dept Neurol, Ann Arbor, MI 48109 USA.
   [Hur, Junguk] Univ N Dakota, Sch Med & Hlth Sci, Dept Basic Sci, Grand Forks, ND 58201 USA.
   [Pennathur, Subramaniam; Kretzler, Matthias; Brosius, Frank C., III] Univ Michigan, Dept Internal Med, Div Nephrol, Ann Arbor, MI 48109 USA.
C3 University of Michigan System; University of Michigan; University of
   North Dakota Grand Forks; University of Michigan System; University of
   Michigan
RP Feldman, EL (corresponding author), Univ Michigan, Dept Neurol, Ann Arbor, MI 48109 USA.
EM efeldman@med.umich.edu
RI Hur, Junguk/J-6229-2019; Pennathur, Subramaniam/O-7032-2017
OI Hinder, Lucy/0000-0002-5206-8010; Pennathur,
   Subramaniam/0000-0003-3628-6883; Hur, Junguk/0000-0002-0736-2149;
   Feldman, Eva/0000-0002-9162-2694
FU National Institutes of Health [1DP3-DK-094292, 1R-24082841]; JDRF;
   American Diabetes Association; Program for Neurology Research and
   Discovery; A. Alfred Taubman Medical Research Institute; National
   Institute of Diabetes and Digestive and Kidney Diseases [P30DK092926,
   P30DK020572, P30DK081943] Funding Source: NIH RePORTER
FX Funding was provided by the National Institutes of Health
   (1DP3-DK-094292,1R-24082841 to M.K., F.C.B., and ELF.), JDRF
   (postdoctoral fellowships to J.H. and L.M.H.), the American Diabetes
   Association, the Program for Neurology Research and Discovery, and the
   A. Alfred Taubman Medical Research Institute.
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   Zhang HY, 2008, AM J PHYSIOL-RENAL, V295, pF1071, DOI 10.1152/ajprenal.90208.2008
   Zhou L, 2013, AM J PHYSIOL-RENAL, V305, pF1491, DOI 10.1152/ajprenal.00004.2013
NR 47
TC 49
Z9 52
U1 0
U2 23
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0012-1797
EI 1939-327X
J9 DIABETES
JI Diabetes
PD SEP
PY 2015
VL 64
IS 9
BP 3294
EP 3304
DI 10.2337/db15-0133
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA CP9AE
UT WOS:000360185300028
PM 25979075
OA Green Published
DA 2025-06-11
ER

PT J
AU Hsu, HC
   Mountz, JD
AF Hsu, Hui-Chen
   Mountz, John D.
TI Metabolic syndrome, hormones, and maintenance of T cells during aging
SO CURRENT OPINION IN IMMUNOLOGY
LA English
DT Review
ID LIFE-SPAN; GUT MICROBIOTA; IMMUNE-SYSTEM; AGED MICE; OXIDATIVE STRESS;
   LEPTIN RECEPTOR; DNA-DAMAGE; OBESE GENE; IN-VIVO; INFLAMMATION
AB Although the phenotype of T-cell senescence has been extensively investigated, few studies have analyzed the factors that promote the generation and maintenance of naive and memory T cells that exist throughout the lifespan of the individuals. Unlike senescent T cells, naive and memory T cells are able to participate in useful immune responses as well as respond to new activation. Hormones such as leptin, ghrelin, insulin-like growth factor 1, IGFBP3, and cytokines, including IL-7, regulate both thymopoiesis and maintenance of naive T cells in the periphery. Although chronic viruses such as cytomegalovirus (CMV) are thought to drive T-cell senescence, other microbes may be important for the maintenance of nonsenescent T cells. Microbiota of the gut can induce metabolic syndrome as well as modulate T-cell development into specific subpopulations of effector cells. Finally, T-cell generation, maintenance, and apoptosis depend upon pathways of energy utilization within the T cells, which parallel those that regulate overall metabolism. Therefore, better understanding of metabolic syndrome, T-cell metabolism, hormones, and microbiota may lead to new insights into the maintenance of proper immune responses in old age.
C1 [Hsu, Hui-Chen; Mountz, John D.] Univ Alabama, Dept Med, Birmingham, AL 35294 USA.
   [Mountz, John D.] Vet Adm Med Ctr, Birmingham, AL 35233 USA.
C3 University of Alabama System; University of Alabama Birmingham; US
   Department of Veterans Affairs; Veterans Health Administration (VHA)
RP Mountz, JD (corresponding author), Univ Alabama, Dept Med, Birmingham, AL 35294 USA.
EM jdmountz@uab.edu
OI Hsu, Hui-Chen/0000-0002-0317-5725
FU NIH/NIA [PO1 AG022064]
FX This research was supported by NIH/NIA PO1 AG022064. We thank Ms. Carol
   Humber for excellent secretarial assistance.
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NR 58
TC 13
Z9 15
U1 0
U2 5
PU CURRENT BIOLOGY LTD
PI LONDON
PA 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND
SN 0952-7915
EI 1879-0372
J9 CURR OPIN IMMUNOL
JI Curr. Opin. Immunol.
PD AUG
PY 2010
VL 22
IS 4
BP 541
EP 548
DI 10.1016/j.coi.2010.05.002
PG 8
WC Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology
GA 645MH
UT WOS:000281462800019
PM 20591642
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Li, N
   Gao, YY
   Zhao, XC
   Wang, L
   Wang, R
   Song, M
   Hu, PH
   Lu, WT
   Zhao, TY
   Huang, FF
   Liu, BF
   Ren, RJ
   Wang, XY
AF Li, Na
   Gao, Yuanyuan
   Zhao, Xiaochuan
   Wang, Lan
   Wang, Ran
   Song, Mei
   Hu, Peihua
   Lu, Wenting
   Zhao, Tianyu
   Huang, Fanfan
   Liu, Bufan
   Ren, Ruojia
   Wang, Xueyi
TI Effects of multiple stress events at different stages of life on the
   incidence of metabolic syndrome
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Article
DE multiple stress; metabolic syndrome; fetal; childhood; adulthood
ID PHYSICAL HEALTH; PREVALENCE; TRENDS; ABUSE; CHINA; RISK
AB Objective: To investigate the effects of multiple stress events in different stages of life on the incidence of metabolic syndrome (MetS). Methods: Miners from Tangshan, China, were recruited for this study. Workers of the Kailuan Mining Group were evaluated to investigate whether exposure to Tangshan earthquakes during the fetal period in 1976. Adult life events and childhood trauma were assessed separately via the Life Event Scale and Childhood Trauma Questionnaire. The subjects were physically examined and general demographic data such as waist circumference were collected. Blood samples were collected for measurement of metabolic parameters. Corticotropin releasing hormone(CRH) levels was measured by enzyme-linked immunosorbent assay (ELISA). The subjects were divided into four groups according to their exposure to traumatic events in different stages of life: no exposure group, 1-exposure group, 2-exposures group, and 3-exposures group. The incidence of MetS, metabolic parameters and CRH levels in each of the four groups was compared. Results: In all, 626 people were enrolled; of these, 183, 262, 150, and 31 were in the no exposure, 1-exposure, 2-exposures, and 3-exposure groups, respectively. A remarkable variation in the incidence of MetS was observed among the four groups (x(2) = 16.462, P<0.001). MetS incidence increased with the increasing number of traumatic events, except for in the no exposure group (17.9% in 1-exposure group, 24.7% in 2-exposure group, and 48.4% in the 3-exposure group). Multivariate logistic regression analysis showed that exposure to multiple stress during the fetal, childhood, and adult stages of life represent independent risk factors for developing MetS (OR=3.134, 95%CI=1.042-9.429). Smoking increased the risk of developing MetS (OR=1.809, 95%CI=1.140-2.871). Conclusions: Exposure to multiple traumatic events in distinct life stages increases the risk of developing MetS. Smoking is a risk factor for developing MetS.
C1 [Li, Na; Gao, Yuanyuan; Zhao, Xiaochuan; Wang, Lan; Wang, Ran; Song, Mei; Hu, Peihua; Lu, Wenting; Zhao, Tianyu; Huang, Fanfan; Liu, Bufan; Ren, Ruojia; Wang, Xueyi] Hebei Med Univ, Hosp 1, Dept Psychiat, Shijiazhuang, Peoples R China.
   [Li, Na; Gao, Yuanyuan; Zhao, Xiaochuan; Wang, Lan; Wang, Ran; Song, Mei; Hu, Peihua; Lu, Wenting; Zhao, Tianyu; Huang, Fanfan; Liu, Bufan; Ren, Ruojia; Wang, Xueyi] Hebei Med Univ, Mental Hlth Ctr, Shijiazhuang, Peoples R China.
C3 Hebei Medical University; Hebei Medical University
RP Wang, XY (corresponding author), Hebei Med Univ, Hosp 1, Dept Psychiat, Shijiazhuang, Peoples R China.; Wang, XY (corresponding author), Hebei Med Univ, Mental Hlth Ctr, Shijiazhuang, Peoples R China.
EM ydyywxy@163.com
RI han, wei/ABG-2691-2021; Wang, Ran/GRX-9114-2022; Gao,
   Yuanyuan/LXB-0646-2024
FU Provincial Science and Technology Program of Hebei Province [21377711D];
   Hebei Medical University Clinical Research Innovation Team
   [2022LCTD-A1]; Introduce Foreign Intellectual Projects of Finance
   Department in Hebei Province [YZ202306]; Medical Research Projects from
   Health Commission of Hebei Province [20210418]; Clinical medicine
   excellent talents training project of Hebei Province
FX The author(s) declare that financial support was received for the
   research, authorship, and/or publication of this article. This study was
   supported by Provincial Science and Technology Program of Hebei Province
   (21377711D), Hebei Medical University Clinical Research Innovation Team
   (2022LCTD-A1) and Introduce Foreign Intellectual Projects of Finance
   Department in Hebei Province (YZ202306). Medical Research Projects from
   Health Commission of Hebei Province (20210418). The government funded
   clinical medicine excellent talents training project of Hebei Province
   (No.ZF2023021).
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NR 43
TC 0
Z9 0
U1 1
U2 3
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD OCT 22
PY 2024
VL 15
AR 1419443
DI 10.3389/fendo.2024.1419443
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA L0R1Z
UT WOS:001347872200001
PM 39502566
OA gold
DA 2025-06-11
ER

PT J
AU Helal, O
   Defoort, C
   Robert, S
   Marin, C
   Lesavre, N
   Lopez-Miranda, J
   Risérus, U
   Basu, S
   Lovegrove, J
   McMonagle, J
   Roche, HM
   Dignat-George, F
   Lairon, D
AF Helal, O.
   Defoort, C.
   Robert, S.
   Marin, C.
   Lesavre, N.
   Lopez-Miranda, J.
   Riserus, U.
   Basu, S.
   Lovegrove, J.
   McMonagle, J.
   Roche, H. M.
   Dignat-George, F.
   Lairon, D.
TI Increased levels of microparticles originating from endothelial cells,
   platelets and erythrocytes in subjects with metabolic syndrome:
   Relationship with oxidative stress
SO NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
LA English
DT Article
DE Platelets microparticles; Endothelial microparticles; Erythrocytes
   microparticles; Metabolic syndrome; Glutathione peroxydase;
   8-Iso-prostaglandin F(2) alpha
ID CIRCULATING MICROPARTICLES; CELLULAR MICROPARTICLES;
   CARDIOVASCULAR-DISEASE; INSULIN-RESISTANCE; ATHEROSCLEROSIS;
   HYPERTENSION; ACTIVATION; GENERATION; OBESITY; MARKER
AB Background and aims: The Metabolic Syndrome (MetS) is associated with increased cardiovascular risk. Circulating microparticles (MP) are involved in the pathogenesis of atherothrombotic disorders and are raised in individual with CVD. We measured their level and cellular origin in subjects with MetS and analyzed their associations with 1/anthropometric and biological parameters of MetS, 2/inflammation and oxidative stress markers.
   Methods and results: Eighty-eight subjects with the MetS according to the NCEP-ATPIII definition were enrolled in a bicentric study and compared to 27 healthy controls. AnnexinV-positive MP (TMP), MP derived from platelets (PMP), erythrocytes (ErMP), endothelial cells (EMP), leukocytes (LMP) and granulocytes (PNMP) were determined by flow cytometry. MetS subjects had significantly higher counts/mu l of TMP (730.6 +/- 49.7 vs 352.8 +/- 35.6), PMP (416.0 +/- 43.8 vs 250.5 +/- 23.5), ErMP (243.8 +/- 22.1 vs 73.6 +/- 19.6) and EMP (7.8 +/- 0.8 vs 4.0 +/- 1.0) compared with controls. LMP and PNMP were not statistically different between groups. Multivariate analysis demonstrated that each criterion for the MetS influenced the number of TMP. Waist girth was a significant determinant of PMP and EMP level and blood pressure was correlated with EMP level. Glycemia positively correlated with PMP level whereas dyslipidemia influenced EMP and ErMP levels. Interestingly, the oxidative stress markers, plasma glutathione peroxy-dase and urinary 8-iso-prostaglandin F(2) alpha, independently influenced TMP and PMP levels whereas inflammatory markers did not, irrespective of MP type.
   Conclusion: Increased levels of TMP, PMP, ErMP and EMP are associated with individual metabolic abnormalities of MetS and oxidative stress. Whether MP assessment may represent a marker for risk stratification or a target for pharmacological intervention deserves further investigation. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Helal, O.; Defoort, C.; Lairon, D.] Univ Aix Marseille, Fac Med, UMR INSERM 476, INRA 1260, F-13385 Marseille 05, France.
   [Robert, S.; Dignat-George, F.] Univ Aix Marseille 2, Fac Pharm, CHU La Concept,Lab Immunol & Hematol, INSERM,UMR 608, Marseille, France.
   [Marin, C.; Lopez-Miranda, J.] Univ Cordoba, Hosp Univ Reina Sofia, Unidad Lipidos & Arteriosclerosis,Inst Salud Carl, CIBER Fisiopatol Obesidad & Nutr CB06 03, Cordoba, Spain.
   [Lesavre, N.] Assistance Publ Hop Marseille, CIC, F-13009 Marseille, France.
   [Riserus, U.] Uppsala Univ, Dept Publ Hlth & Caring Sci Clin Nutr & Metab, S-75185 Uppsala, Sweden.
   [Basu, S.] Univ Uppsala Hosp, Dept Publ Hlth & Caring Sci Oxidat Stress & Infla, S-75185 Uppsala, Sweden.
   [Basu, S.] Univ Uppsala Hosp, Ctr Excellence Inflammat, S-75185 Uppsala, Sweden.
   [Lovegrove, J.] Univ Reading, Sch Food & Nutr Sci, Reading RG6 6AP, Berks, England.
   [Lovegrove, J.] Univ Reading, Inst Cardiovasc & Metab Res, Reading RG6 6AP, Berks, England.
   [McMonagle, J.; Roche, H. M.] Univ Coll Dublin, Sch Publ Hlth & Populat Sci, UCD Conway Inst, Dublin 4, Ireland.
C3 Institut National de la Sante et de la Recherche Medicale (Inserm);
   Aix-Marseille Universite; INRAE; Aix-Marseille Universite; Institut
   National de la Sante et de la Recherche Medicale (Inserm); Assistance
   Publique-Hopitaux de Marseille; CIBER - Centro de Investigacion
   Biomedica en Red; CIBEROBN; Hospital Universitario Reina Sofia -
   Cordoba; Universidad de Cordoba; Institut National de la Sante et de la
   Recherche Medicale (Inserm); Aix-Marseille Universite; Assistance
   Publique-Hopitaux de Marseille; Uppsala University; Uppsala University;
   Uppsala University Hospital; Uppsala University; Uppsala University
   Hospital; University of Reading; University of Reading; University
   College Dublin
RP Defoort, C (corresponding author), Univ Aix Marseille, Fac Med, UMR INSERM 476, INRA 1260, 27 Bd Jean Moulin, F-13385 Marseille 05, France.
EM catherine.defoort@univmed.fr
RI Lovegrove, Julie/LRV-2592-2024; Lopez-Miranda, Jose/Y-8306-2019; Marin
   Hinojosa, Carmen/AFO-1294-2022; DIGNAT-GEORGE, Francoise/R-1129-2016
OI Roche, Helen/0000-0002-0628-3318; Lopez-Miranda,
   Jose/0000-0002-8844-0718; Lairon, Denis/0000-0001-9941-3742;
   DIGNAT-GEORGE, Francoise/0000-0001-7006-4462
FU European Commission [FOOD-CT-2003-505944]
FX This research was partly supported by funding from the European
   Commission, FP6 as part of the LIPGENE project (FOOD-CT-2003-505944).
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NR 32
TC 95
Z9 102
U1 0
U2 10
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0939-4753
J9 NUTR METAB CARDIOVAS
JI Nutr. Metab. Carbiovasc. Dis.
PD SEP
PY 2011
VL 21
IS 9
BP 665
EP 671
DI 10.1016/j.numecd.2010.01.004
PG 7
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism; Nutrition
   & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism;
   Nutrition & Dietetics
GA 830CW
UT WOS:000295635700008
PM 20399083
DA 2025-06-11
ER

PT J
AU Miyagawa, R
   Asakura, T
   Nakamura, T
   Okada, H
   Iwaki, S
   Sobel, BE
   Fujii, S
AF Miyagawa, Ryu
   Asakura, Takefumi
   Nakamura, Tomomi
   Okada, Hiromi
   Iwaki, Soichiro
   Sobel, Burton E.
   Fujii, Satoshi
TI Increased expression of plasminogen activator inhibitor type-1 (PAI-1)
   in HEPG2 cells induced by insulin mediated by the 3′-untranslated region
   of the PAI-1 gene and its pharmacologic implications
SO CORONARY ARTERY DISEASE
LA English
DT Article
DE cardiovascular risk; insulin; liver; metabolic syndrome; oxidative
   stress; plasminogen activator inhibitor-1; statins; thrombosis
ID POSTTRANSCRIPTIONAL REGULATION; METABOLIC SYNDROME; MESSENGER-RNA;
   AUGMENTATION; PROMOTER; STATINS
AB Objective Insulin increases, through several molecular mechanisms, expression of plasminogen activator inhibitor-1 (PAI-1), the major physiologic inhibitor of fibrinolysis. This phenomenon has been implicated as a cause of accelerated coronary artery disease and the increased incidence of acute coronary syndromes associated with type 2 diabetes. We have previously reported that physiologic and pharmacologic concentrations of insulin induce PAI-1 synthesis in human HepG2 cells and that simvastatin can attenuate its effects. This study was performed to further elucidate mechanisms responsible for the insulin-induced PAI-1 production.
   Methods Concentrations of PAI-1 mRNA were determined by real-time PCR, and PAI-1 protein was assayed by western blotting. PAI-1 promoter (-829 to +36 bp) activity was assayed with the use of luciferase reporter assays. The potential role of the 30-untranslated region (UTR) in the PAI-1 gene was assayed with the use of luciferase constructs containing the 30-UTR. Oxidative stress was measured by loading cells with carboxy-2,7 dichlorodihydrofluorescein.
   Results Insulin increased PAI-1 promoter activity, PAI-1 mRNA, and accumulation of PAI-1 protein in the conditioned media. Insulin-inducible PAI-1 promoter activity was attenuated by simvastatin. Experiments performed with luciferase reporters containing the 3'-UTR showed that insulin increased luciferase activity through this region. Insulin also increased oxidative stress. Both insulin-inducible luciferase activity through the 3'-UTR and oxidative stress were attenuated by simvastatin.
   Conclusion Insulin can increase PAI-1 expression through multiple mechanisms including induction mediated by the 3'-UTR of the PAI-1 gene. Accordingly, beneficial pleiotropic effects of statins on coronary artery disease may be attributable, in part, to attenuation of overexpression of PAI-1 mediated by the 3'-UTR in syndromes of insulin resistance ( such as the metabolic syndrome) and type 2 diabetes. Coron Artery Dis 21: 144-150 (C) 2010 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
C1 [Fujii, Satoshi] Nagoya City Univ, Dept Mol & Cellular Pathobiol & Therapeut, Sch Pharmaceut Sci, Mizuho Ku, Nagoya, Aichi 4678603, Japan.
   [Sobel, Burton E.] Univ Vermont, Cardiovasc Res Inst, Colchester, VT USA.
C3 Nagoya City University; University of Vermont
RP Fujii, S (corresponding author), Nagoya City Univ, Dept Mol & Cellular Pathobiol & Therapeut, Sch Pharmaceut Sci, Mizuho Ku, Tanabe Dori 3-1, Nagoya, Aichi 4678603, Japan.
EM sfujii@phar.nagoya-cu.ac.jp
OI gong chuan, long/0009-0008-1975-938X
FU Ministry of Education, Science, Sport, and Culture of Japan
FX The authors thank Professor Shinichi Hoshino (Department of Biological
   Chemistry, Nagoya City University, Japan) for useful advice and helpful
   discussions, and Lorraine Dales for assistance in preparation of the
   manuscript. This work was supported in part by grants-in-aid for
   scientific research from the Ministry of Education, Science, Sport, and
   Culture of Japan.
CR Alessi MC, 2008, THROMB HAEMOSTASIS, V99, P995, DOI 10.1160/TH07-11-0682
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NR 27
TC 11
Z9 13
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0954-6928
EI 1473-5830
J9 CORONARY ARTERY DIS
JI Coronary Artery Dis.
PD MAY
PY 2010
VL 21
IS 3
BP 144
EP 150
DI 10.1097/MCA.0b013e328335790e
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 622ML
UT WOS:000279667800003
PM 20299979
DA 2025-06-11
ER

PT J
AU Klisic, A
   Kavaric, N
   Ninic, A
AF Klisic, A.
   Kavaric, N.
   Ninic, A.
TI Serum cystatin C levels are associated with triglycerides/high-density
   lipoprotein cholesterol ratio in adolescent girls ages between 16-19
   years old
SO EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
LA English
DT Article
DE Cystatin C; Cardiometabolic risk; Dyslipidemia; Inflammation
ID METABOLIC SYNDROME; OXIDATIVE STRESS; MARKERS; PREDICT; INDEX
AB OBJECTIVE: The pathophysiological role of cystatin C in cardiometabolic disorders is not completely explored in young population. On the other hand, together with the increase in obesity, dyslipidemia and insulin resistance (IR) are often observed even in youngsters. The aim of the study was to investigate the relationship between cystatin C and triglycerides-to-high-density lipoprotein cholesterol ratio (TG/HDL-c). as an indicator of dyslipidemia and a surrogate marker of IR in the cohort of adolescent girls ages between 16-19 years.
   PATIENTS AND METHODS: A total of 99 girls were included in the study. Anthropometric and biochemical parameters were provided. Associations of biochemical markers with TG/HDL-c ratio were tested using univariable and multivariable ordinal regression analysis for TG/HDL-c ratio tertiles as dependent variable.
   RESULTS: In univariate analysis, cystatin C levels were significantly associated with TG/HDL-c ratio (OR=1.813; 95% Cl: 1.190-2.757, p=0.005). Furthermore, multivariate analysis revealed that cystatin C was an independent predictor of TG/HDL-c ratio when body mass index and high sensitivity C-reactive protein (i.e., markers that were significantly correlated with TG/HDL-c ratio in Spearman's correlation analysis) were included in the Model. Adjusted odds for cystatin C (OR=1.621; 95% CI: 1.028-2.552, p=0.037) demonstrated that rise in cystatin C by 0.1 mg/L increased the probability for higher TG/HDL-c tertile group by 1.621 times.
   CONCLUSIONS: Serum cystatin C levels are associated with TG/HDL-c ratio in adolescent girls. Longitudinal studies are needed to confirm the causal relationship between cystatin C and TG/HDL-c ratio and to further explore its diagnostic and therapeutic potential in dyslipidemia and insulin resistance in young population.
C1 [Klisic, A.; Kavaric, N.] Univ Montenegro, Primary Hlth Care Ctr, Fac Med, Podgorica, Montenegro.
   [Ninic, A.] Univ Belgrade, Fac Pharm, Dept Med Biochem, Belgrade, Serbia.
C3 University of Montenegro; University of Belgrade
RP Klisic, A (corresponding author), Univ Montenegro, Primary Hlth Care Ctr, Fac Med, Podgorica, Montenegro.
EM aleksandranklisic@gmail.com
RI Klisic, Aleksandra/ABC-9219-2020
OI Klisic, Aleksandra/0000-0001-7870-0996
FU Ministry of Science, Montenegro; Ministry of Education, Science and
   Technological Development, Republic of Serbia [451-03-68/2020-14/200161]
FX This work was financially supported in part by a grant from the Ministry
   of Science, Montenegro and the Ministry of Education, Science and
   Technological Development, Republic of Serbia (project number
   451-03-68/2020-14/200161).
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NR 36
TC 16
Z9 16
U1 0
U2 1
PU VERDUCI PUBLISHER
PI ROME
PA VIA GREGORIO VII, ROME, 186-00165, ITALY
SN 1128-3602
J9 EUR REV MED PHARMACO
JI Eur. Rev. Med. Pharmacol. Sci.
PY 2020
VL 24
IS 20
BP 10680
EP 10686
DI 10.26355/eurrev_202010_23426
PG 7
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA OL1FI
UT WOS:000585086700053
PM 33155226
DA 2025-06-11
ER

PT J
AU Kochi, T
   Shimizu, M
   Ohno, T
   Baba, A
   Sumi, T
   Kubota, M
   Shirakami, Y
   Tsurumi, H
   Tanaka, T
   Moriwaki, H
AF Kochi, Takahiro
   Shimizu, Masahito
   Ohno, Tomohiko
   Baba, Atsushi
   Sumi, Takafumi
   Kubota, Masaya
   Shirakami, Yohei
   Tsurumi, Hisashi
   Tanaka, Takuji
   Moriwaki, Hisataka
TI Preventive effects of the angiotensin-converting enzyme inhibitor,
   captopril, on the development of azoxymethane-induced colonic
   preneoplastic lesions in diabetic and hypertensive rats
SO ONCOLOGY LETTERS
LA English
DT Article
DE metabolic syndrome; colon carcinogenesis; hypertension;
   angiotensin-converting enzyme inhibitor; renin-angiotensin system
ID C57BL/KSJ-DB/DB OBESE MICE; METABOLIC SYNDROME; OXIDATIVE STRESS;
   CANCER; SYSTEM; CARCINOGENESIS; MORTALITY; RECEPTOR; MODEL; RISK
AB Metabolic syndrome (Mets), including diabetes and hypertension, increases the risk of colorectal cancer via the induction of chronic inflammation, acceleration of oxidative stress, and activation of the renin-angiotensin system. The present study examined the possible inhibitory effects of captopril, an angiotensin-converting enzyme (ACE) inhibitor and anti hypertensive drug, on the development of azoxymethane (AOM)-induced colonic premalignant lesions, aberrant crypt foci (ACF), in SHRSP.Z-Lepr(fa)/IzmDmcr (SHRSP-ZF) diabetic and hypertensive rats. Male 6-week-old SHRSP-ZF rats were administered two, weekly intraperitoneal injections of AOM (20 mg/kg body weight). Following the second injection, the rats received drinking water containing captopril (8 mg/kg/day) for two weeks. At sacrifice, captopril administration significantly lowered the blood pressure and reduced the total number and size of ACF compared with those observed in the untreated group. The serum levels of angiotensin-II and the expression levels of ACE and angiotensin-II type 1 receptor mRNA on the colonic mucosa decreased following captopril treatment. Captopril also reduced the urinary 8-hydroxy-2'-deoxyguanosine levels and the serum derivatives of reactive oxygen metabolites levels, both of which are oxidative stress markers, but increased the mRNA levels of catalase, an antioxidant enzyme, in the colonic epithelium. Moreover, the expression levels of tumor necrosis factor-alpha, interleukin-18, monocyte chemoattractant protein-1, inducible nitric oxide synthase, vascular endothelial growth factor and proliferating cell nuclear antigen mRNA in the colonic epithelium were decreased significantly following captopril administration. These observations suggested that captopril prevents the development of ACF by inhibiting renin-angiotensin system activation and attenuating inflammation and oxidative stress in SHRSP-ZF rats. Therefore, targeting Mets-related pathophysiological conditions, including renin-angiotensin system activation, may be an effective strategy to prevent colorectal carcinogenesis in patients with Mets, particularly those with hypertension.
C1 [Kochi, Takahiro; Shimizu, Masahito; Ohno, Tomohiko; Baba, Atsushi; Sumi, Takafumi; Kubota, Masaya; Shirakami, Yohei; Tsurumi, Hisashi; Moriwaki, Hisataka] Gifu Univ, Dept Med Gastroenterol, Grad Sch Med, Gifu, Chubu 5011194, Japan.
   [Tanaka, Takuji] Gifu Univ, Dept Tumor Pathol, Grad Sch Med, Gifu, Chubu 5011194, Japan.
C3 Gifu University; Gifu University
RP Shimizu, M (corresponding author), Gifu Univ, Dept Med Gastroenterol, Grad Sch Med, 1-1 Yanagido, Gifu, Chubu 5011194, Japan.
EM shimim-gif@umin.ac.jp
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NR 34
TC 14
Z9 14
U1 0
U2 5
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1792-1074
EI 1792-1082
J9 ONCOL LETT
JI Oncol. Lett.
PD JUL
PY 2014
VL 8
IS 1
BP 223
EP 229
DI 10.3892/ol.2014.2136
PG 7
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA AK1ML
UT WOS:000338179100041
PM 24959250
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Denimal, D
   Monier, S
   Bouillet, B
   Vergés, B
   Duvillard, L
AF Denimal, Damien
   Monier, Serge
   Bouillet, Benjamin
   Verges, Bruno
   Duvillard, Laurence
TI High-Density Lipoprotein Alterations in Type 2 Diabetes and Obesity
SO METABOLITES
LA English
DT Review
DE high-density lipoprotein; type 2 diabetes; obesity; metabolic syndrome;
   cholesterol efflux; glycoxidation; endothelium
ID APOLIPOPROTEIN-A-I; CHOLESTEROL EFFLUX CAPACITY;
   CORONARY-ARTERY-DISEASE; ELEVATED OXIDATIVE STRESS;
   NUCLEAR-MAGNETIC-RESONANCE; PRE-BETA-HDL; METABOLIC SYNDROME;
   INSULIN-RESISTANCE; PARTICLE-SIZE; ADVANCED GLYCATION
AB Alterations affecting high-density lipoproteins (HDLs) are one of the various abnormalities observed in dyslipidemia in type 2 diabetes mellitus (T2DM) and obesity. Kinetic studies have demonstrated that the catabolism of HDL particles is accelerated. Both the size and the lipidome and proteome of HDL particles are significantly modified, which likely contributes to some of the functional defects of HDLs. Studies on cholesterol efflux capacity have yielded heterogeneous results, ranging from a defect to an improvement. Several studies indicate that HDLs are less able to inhibit the nuclear factor kappa-B (NF-kappa B) proinflammatory pathway, and subsequently, the adhesion of monocytes on endothelium and their recruitment into the subendothelial space. In addition, the antioxidative function of HDL particles is diminished, thus facilitating the deleterious effects of oxidized low-density lipoproteins on vasculature. Lastly, the HDL-induced activation of endothelial nitric oxide synthase is less effective in T2DM and metabolic syndrome, contributing to several HDL functional defects, such as an impaired capacity to promote vasodilatation and endothelium repair, and difficulty counteracting the production of reactive oxygen species and inflammation.
C1 [Denimal, Damien; Monier, Serge; Bouillet, Benjamin; Verges, Bruno; Duvillard, Laurence] Univ Burgundy, INSERM, UMR1231, F-21000 Dijon, France.
   [Denimal, Damien; Duvillard, Laurence] CHU Dijon Bourgogne, Dept Biochem, F-21000 Dijon, France.
   [Bouillet, Benjamin; Verges, Bruno] CHU Dijon Bourgogne, Dept Endocrinol & Diabetol, F-21000 Dijon, France.
C3 Institut Agro; AgroSup Dijon; Universite Bourgogne Europe; Institut
   National de la Sante et de la Recherche Medicale (Inserm); Universite
   Bourgogne Europe; CHU Dijon Bourgogne; Universite Bourgogne Europe; CHU
   Dijon Bourgogne
RP Denimal, D (corresponding author), Univ Burgundy, INSERM, UMR1231, F-21000 Dijon, France.; Denimal, D (corresponding author), CHU Dijon Bourgogne, Dept Biochem, F-21000 Dijon, France.
EM damien.denimal@u-bourgogne.fr
RI Bouillet, Benjamin/AAG-8165-2019
OI DENIMAL, Damien/0000-0001-5454-954X; BOUILLET,
   Benjamin/0000-0002-4317-6714
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NR 211
TC 19
Z9 20
U1 1
U2 9
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2218-1989
J9 METABOLITES
JI Metabolites
PD FEB
PY 2023
VL 13
IS 2
AR 253
DI 10.3390/metabo13020253
PG 26
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 9J9OU
UT WOS:000940507600001
PM 36837872
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Xu, MY
   Zhong, FY
   Bruno, RS
   Ballard, KD
   Zhang, J
   Zhu, JJ
AF Xu, Mengyang
   Zhong, Fanyi
   Bruno, Richard S.
   Ballard, Kevin D.
   Zhang, Jing
   Zhu, Jiangjiang
TI Comparative Metabolomics Elucidates Postprandial Metabolic Modifications
   in Plasma of Obese Individuals with Metabolic Syndrome
SO JOURNAL OF PROTEOME RESEARCH
LA English
DT Article
DE targeted metabolic profiling nutrimetabolomics; low-fat milk; rice milk;
   Bayesian LASSO
ID VASCULAR ENDOTHELIAL FUNCTION; MASS-SPECTROMETRY; EPIDEMIOLOGY; WATER;
   DIET
AB Although higher intakes of dairy milk are associated with a lower risk of metabolic syndrome (MetS), the underlying protective mechanism remains unclear. This study investigated the dynamic metabolic profile shift following the ingestion of low-fat milk or an isocaloric volume of rice milk in obese individuals with metabolic syndrome (MetS). In a randomized, double-blind, crossover study, postprandial plasma samples (n = 266) were collected from 19 MetS participants. Plasma samples were analyzed by a targeted metabolomics platform which specifically detects 117 metabolites from 25 metabolic pathways. The comprehensive time course metabolic profiling in MetS participants indicated that the postprandial metabolic profiles distinguish low-fat milk and rice milk consumption in a time-dependent manner. Metabolic biomarkers, such as orotate, leucine/isoleucine and adenine, showed significantly different trends in the two test beverages. Bayesian statistics identified 12 metabolites associated with clinical characteristics of postprandial vascular endothelial function, such as flow-mediated dilation (FMD), postprandial plasma markers of oxidative stress and NO status. Furthermore, metabolic pathway analysis based on these metabolite data indicated the potential utility of metabolomics to provide mechanistic insights of dietary interventions to regulate postprandial metabolic excursions.
C1 [Xu, Mengyang; Zhong, Fanyi; Zhu, Jiangjiang] Miami Univ, Dept Chem & Biochem, Oxford, OH 45056 USA.
   [Bruno, Richard S.] Ohio State Univ, Human Nutr Program, Columbus, OH 43210 USA.
   [Ballard, Kevin D.] Miami Univ, Dept Kinesiol & Hlth, Oxford, OH 45056 USA.
   [Zhang, Jing] Miami Univ, Dept Stat, Oxford, OH 45056 USA.
C3 University System of Ohio; Miami University; University System of Ohio;
   Ohio State University; University System of Ohio; Miami University;
   University System of Ohio; Miami University
RP Zhu, JJ (corresponding author), Miami Univ, Dept Chem & Biochem, Oxford, OH 45056 USA.
EM zhuj6@miamioh.edu
RI Xu, Meng/HJY-7139-2023; Zhu, Jiangjiang/E-4202-2013; Bruno,
   Richard/K-1930-2012
OI Bruno, Richard/0000-0002-6772-2038
FU Miami University; National Dairy Council
FX This study was supported by Miami University (startup fund to JZ) and a
   grant from the National Dairy Council (to RSB). We'd like to extend our
   gratitude to the study participants.
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NR 22
TC 9
Z9 9
U1 0
U2 19
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1535-3893
EI 1535-3907
J9 J PROTEOME RES
JI J. Proteome Res.
PD AUG
PY 2018
VL 17
IS 8
BP 2850
EP 2860
DI 10.1021/acs.jproteome.8b00315
PG 11
WC Biochemical Research Methods
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA GP7TQ
UT WOS:000441112800027
PM 29975061
DA 2025-06-11
ER

PT J
AU Ko, KD
   Cho, B
   Lee, WC
   Lee, HW
   Lee, HK
   Oh, BJ
AF Ko, Ki Dong
   Cho, BeLong
   Lee, Won Chul
   Lee, Hae Won
   Lee, Hyun Ki
   Oh, Bum Jo
TI Obesity Explains Gender Differences in the Association Between Education
   Level and Metabolic Syndrome in South Korea: The Results From the Korean
   National Health and Nutrition Examination Survey 2010
SO ASIA-PACIFIC JOURNAL OF PUBLIC HEALTH
LA English
DT Article
DE metabolic syndrome; educational level; gender differences
ID SOCIOECONOMIC-STATUS; ABDOMINAL OBESITY; URBAN-POPULATION; RISK;
   PREVALENCE; ADULTS; DISPARITIES; DIAGNOSIS; CANCER
AB This study aimed to examine the association of educational level with metabolic syndrome (MS) and its risk factors by gender in South Korea. A total of 6178 participants aged 20 years or older from The Fifth Korean National Health and Nutrition Examination Survey were included in this study. A generalized linear model and adjusted proportion were used to identify educational disparities in MS, its components, and its risk factors (smoking, high-risk alcohol consumption, obesity, and stress). In women, a clearly inverse association between education level and MS were observed with significant trend, and the decreasing trends of all risk factors across education quartiles were in line with the inverse association. However, the association between education level and MS was not observed with a significant trend among men. An opposite trend of risk factors across education levels was shown in men, with an increasing trend for obesity and decreasing trends for smoking and high-risk alcohol consumption. These findings demonstrate that obesity can explain gender differences in the association between education level and MS in South Korea.
C1 [Ko, Ki Dong] Gachon Univ, Inchon, South Korea.
   [Cho, BeLong; Lee, Hae Won; Lee, Hyun Ki; Oh, Bum Jo] Seoul Natl Univ Hosp, Seoul 110744, South Korea.
   [Lee, Won Chul] Catholic Univ Korea, Seoul, South Korea.
C3 Gachon University; Seoul National University (SNU); Seoul National
   University Hospital; Catholic University of Korea
RP Cho, B (corresponding author), Seoul Natl Univ, Coll Med, Seoul Natl Univ Hosp, Dept Family Med, 110-744 101 Daehangno, Seoul, South Korea.
EM belong.cho@gmail.com
RI Oh, Bumjo/GWN-2776-2022; Cho, Belong/GLU-3443-2022; Lee,
   Eun-Hye/KDN-5679-2024; Oh, Bumjo/O-2462-2017
OI Oh, Bumjo/0000-0002-2468-0755
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NR 34
TC 3
Z9 3
U1 0
U2 1
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1010-5395
EI 1941-2479
J9 ASIA-PAC J PUBLIC HE
JI Asia-Pac. J. Public Health
PD MAR
PY 2015
VL 27
IS 2
BP NP630
EP NP639
DI 10.1177/1010539513488624
PG 10
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA CF5GT
UT WOS:000352586200063
PM 23687256
DA 2025-06-11
ER

PT J
AU Bestermann, WH
AF Bestermann, William H., Jr.
TI The ADMA-Metformin Hypothesis: Linking the Cardiovascular Consequences
   of the Metabolic Syndrome and Type 2 Diabetes
SO CARDIORENAL MEDICINE
LA English
DT Article
DE ADMA; Asymmetric dimethylarginine; Diabetes type 2; Hyperlipidemia;
   Hypertension; Insulin resistance; Metabolic syndrome; Metformin
ID NITRIC-OXIDE SYNTHASE; RIBOSOMAL-PROTEIN S6-KINASE-1; ASYMMETRIC
   DIMETHYLARGININE; INSULIN-RESISTANCE; OXIDATIVE STRESS;
   EPITHELIAL-CELLS; HYPERTENSION; DIMETHYLAMINOHYDROLASE; PATHWAY;
   DYSFUNCTION
AB Metformin and asymmetric dimethylarginine (ADMA) are structural analogs. They have opposite effects at multiple points on complex signaling pathways that coordinate energy, molecular synthesis, growth, and metabolism with nutrient intake. Excess saturated fats and glucose may initiate the methylation of arginine residues in proteins involved in the transcription of genes mediating inflammation, cell proliferation, apoptosis, and oncogenesis. Free ADMA may appear in the circulation after proteolysis of these proteins when the work of transcription is complete and ADMA subsequently functions as a signaling molecule. In children, ADMA levels are not significantly related to the usual metabolic syndrome risk factors but instead there is a significant association between ADMA and alkaline phosphatase a marker of normal growth. There is only one direct study that shows that ADMA negates the metabolic effects of metformin. There are no investigations that demonstrate that metformin blocks the effect of ADMA and so this review must be considered hypothesis generating. The potential implications of the metformin-ADMA relationship merit further investigation. Copyright (c) 2011 S. Karger AG, Basel
C1 [Bestermann, William H., Jr.] Vasc Med Ctr, Holston Med Grp, Kingsport, TN USA.
RP Bestermann, WH (corresponding author), 105 W Stone Dr, Kingsport, TN 37660 USA.
EM whb@hmgkpt.com
RI Bestermann, William/GPX-2901-2022
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NR 45
TC 25
Z9 26
U1 0
U2 3
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1664-3828
EI 1664-5502
J9 CARDIORENAL MED
JI CardioRenal Med.
PY 2011
VL 1
IS 4
BP 211
EP 219
DI 10.1159/000332382
PG 9
WC Cardiac & Cardiovascular Systems; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Urology & Nephrology
GA 051ZN
UT WOS:000312167600001
PM 22135630
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Elenkov, IJ
   Iezzoni, DG
   Daly, A
   Harris, AG
   Chrousos, GP
AF Elenkov, IJ
   Iezzoni, DG
   Daly, A
   Harris, AG
   Chrousos, GP
TI Cytokine dysregulation, inflammation and well-being
SO NEUROIMMUNOMODULATION
LA English
DT Review
DE autoimmune diseases; cytokines; inflammation; interleukins; stress;
   tumor necrosis factor
ID TUMOR-NECROSIS-FACTOR; CORTICOTROPIN-RELEASING HORMONE;
   PITUITARY-ADRENAL AXIS; GENE-RELATED PEPTIDE; MINIMAL PERSISTENT
   INFLAMMATION; RESPIRATORY-DISTRESS-SYNDROME; INDUCED IL-12 PRODUCTION;
   MAST-CELL DEGRANULATION; FACTOR-ALPHA RELEASE; T-CELLS
AB Cytokines mediate and control immune and inflammatory responses. Complex interactions exist between cytokines, inflammation and the adaptive responses in maintaining homeostasis, health, and well-being. Like the stress response, the inflammatory reaction is crucial for survival and is meant to be tailored to the stimulus and time. A full-fledged systemic inflammatory reaction results in stimulation of four major programs: the acute-phase reaction, the sickness syndrome, the pain program, and the stress response, mediated by the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. Common human diseases such as atopy/allergy, autoimmunity, chronic infections and sepsis are characterized by a dysregulation of the pro-versus anti-inflammatory and T helper (Th)1 versus Th2 cytokine balance. Recent evidence also indicates the involvement of pro-inflammatory cytokines in the pathogenesis of atherosclerosis and major depression, and conditions such as visceral-type obesity, metabolic syndrome and sleep disturbances. During inflammation, the activation of the stress system, through induction of a Th2 shift, protects the organism from systemic 'overshooting' with Th1/pro-inflammatory cytokines. Under certain conditions, however, stress hormones may actually facilitate inflammation through induction of interleukin (IL)-1, IL-6, IL-8, IL-18, tumor necrosis factor-alpha and C-reactive protein production and through activation of the corticotropin-releasing hormone/substance P-histamine axis. Thus, a dysfunctional neuroendocrine-immune interface associated with abnormalities of the 'systemic anti-inflammatory feedback' and/or 'hyperactivity' of the local pro-inflammatory factors may play a role in the pathogenesis of atopic/allergic and autoimmune diseases, obesity, depression, and atherosclerosis. These abnormalities and the failure of the adaptive systems to resolve inflammation affect the well-being of the individual, including behavioral parameters, quality of life and sleep, as well as indices of metabolic and cardiovascular health. These hypotheses require further investigation, but the answers should provide critical insights into mechanisms underlying a variety of common human immune-related diseases. Copyright (C) 2005 S. Karger AG, Basel.
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C3 National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver
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RP NICHHD, NIH, Bldg 10,Room 1E-1-3140, Bethesda, MD 20892 USA.
EM Chrousog@mail.nih.gov
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NR 145
TC 386
Z9 435
U1 2
U2 79
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1021-7401
EI 1423-0216
J9 NEUROIMMUNOMODULAT
JI Neuroimmunomodulation
PY 2005
VL 12
IS 5
BP 255
EP 269
DI 10.1159/000087104
PG 15
WC Endocrinology & Metabolism; Immunology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Immunology; Neurosciences & Neurology
GA 964WN
UT WOS:000231911800001
PM 16166805
DA 2025-06-11
ER

PT J
AU Khanna, S
   Bishnoi, M
   Kondepudi, KK
   Shukla, G
AF Khanna, Sakshi
   Bishnoi, Mahendra
   Kondepudi, Kanthi Kiran
   Shukla, Geeta
TI Synbiotic (Lactiplantibacillus pentosus GSSK2 and
   isomalto-oligosaccharides) supplementation modulates pathophysiology and
   gut dysbiosis in experimental metabolic syndrome
SO SCIENTIFIC REPORTS
LA English
DT Article
ID HIGH-FAT DIET; MICROBIOTA; PROBIOTICS; OBESITY; MICE; ENDOTOXEMIA;
   MECHANISMS; PROTECTS; LIVER
AB Metabolic syndrome a lifestyle disease, where diet and gut microbiota play a prodigious role in its initiation and progression. Prophylactic bio-interventions employing probiotics and prebiotics offer an alternate nutritional approach towards attenuating its progression. The present study aimed to evaluate the protective efficacy of a novel synbiotic (Lactiplantibacillus pentosus GSSK2 + isomalto-oligosaccharides) in comparison to orlistat in an experimental model of metabolic syndrome. It was observed that supplementation of synbiotic for 12 weeks to Sprague Dawley rats fed with high fat diet (HFD), ameliorated the morphometric parameters i.e. weight gain, abdominal circumference, Lee's index, BMI and visceral fat deposition along with significantly increased fecal Bacteroidetes to Firmicutes ratio, elevated population of Lactobacillus spp., Akkermansia spp., Faecalibacterium spp., Roseburia spp. and decreased Enterobacteriaceae compared with HFD animals. Additionally, synbiotic administration to HFD animals exhibited improved glucose clearance, lipid biomarkers, alleviated oxidative stress, prevented leaky gut phenotype, reduced serum lipopolysaccharides and modulated the inflammatory, lipid and glucose metabolism genes along with restored histomorphology of adipose tissue, colon and liver compared with HFD animals. Taken together, the study highlights the protective potential of synbiotic in comparison with its individual components in ameliorating HFD-induced metabolic complications.
C1 [Khanna, Sakshi; Shukla, Geeta] Panjab Univ, Dept Microbiol, Basic Med Sci, Basic Med Sci Block A,South Campus, Chandigarh 160014, India.
   [Bishnoi, Mahendra; Kondepudi, Kanthi Kiran] Natl Agrifood Biotechnol Inst NABI, Food & Nutr Biotechnol Div, Hlth Gut Res Grp, Ajitgarh 140306, Punjab, India.
C3 Panjab University; Department of Biotechnology (DBT) India; National
   Agri Food Biotechnology Institute (NABI)
RP Shukla, G (corresponding author), Panjab Univ, Dept Microbiol, Basic Med Sci, Basic Med Sci Block A,South Campus, Chandigarh 160014, India.; Kondepudi, KK (corresponding author), Natl Agrifood Biotechnol Inst NABI, Food & Nutr Biotechnol Div, Hlth Gut Res Grp, Ajitgarh 140306, Punjab, India.
EM kiran@nabi.res.in; geeta_shukla@pu.ac.in
RI Bishnoi, Mahendra/CAG-3229-2022; Kondepudi, Kanthi/P-8336-2014
OI Bishnoi, Mahendra/0000-0002-7785-1204; Kondepudi, Kanthi
   Kiran/0000-0001-8036-7555
FU Indian Council of Medical Research, India [3/1/3 JRF-2016/HRD-51];
   Panjab University, Chandigarh; National Agri-Food Biotechnology
   Institute, Mohali
FX The financial support provided by the Indian Council of Medical
   Research, India (3/1/3 JRF-2016/HRD-51) for carrying the present study;
   Panjab University, Chandigarh and National Agri-Food Biotechnology
   Institute, Mohali for providing funds and research facilities are highly
   acknowledged.
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NR 58
TC 15
Z9 15
U1 4
U2 8
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD NOV 1
PY 2021
VL 11
IS 1
AR 21397
DI 10.1038/s41598-021-00601-2
PG 16
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA WQ3NW
UT WOS:000713727200012
PM 34725349
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Ghazimoradi, M
   Saberi-Karimian, M
   Mohammadi, F
   Sahebkar, A
   Tavallaie, S
   Safarian, H
   Ferns, GA
   Ghayour-Mobarhan, M
   Moohebati, M
   Esmaeili, H
   Ahmadinejad, M
AF Ghazimoradi, Maryam
   Saberi-Karimian, Maryam
   Mohammadi, Farzane
   Sahebkar, Amirhossein
   Tavallaie, Shima
   Safarian, Hamideh
   Ferns, Gordon A.
   Ghayour-Mobarhan, Majid
   Moohebati, Mohsen
   Esmaeili, Habibollah
   Ahmadinejad, Malihe
TI The Effects of Curcumin and Curcumin-Phospholipid Complex on the Serum
   Pro-oxidant-Antioxidant Balance in Subjects with Metabolic Syndrome
SO PHYTOTHERAPY RESEARCH
LA English
DT Article
DE metabolic syndrome; curcumin; pro-oxidant-antioxidant balance
ID RANDOMIZED CONTROLLED-TRIAL; OXIDATIVE STRESS; OBESE INDIVIDUALS;
   DISEASE; PROOXIDANT; CHEMISTRY; AGENT; CELLS
AB Metabolic syndrome (MetS) is defined by a clustering of metabolic and anthropometric abnormalities and is associated by an increased risk of cardiovascular disease. We have investigated the effect of curcumin supplementation on the serum pro-oxidant-antioxidant balance (PAB) in patients with MetS. This double-blind, randomized, placebo-controlled trial was conducted over 6weeks. Subjects (n=120) were randomly allocated to one of three groups (curcumin, phospholipidated curcumin, and placebo). The curcumin group received 1g/day of simple curcumin, the phospholipidated curcumin group received 1g/day of phospholipidated curcumin (containing 200mg of pure curcumin), and the control group received 1g/day of placebo. Serum PAB was measured before and after the intervention (at baseline and at 6weeks). Data analyses were performed using spss software (version 16.0). Serum PAB increased significantly in the curcumin group (p<0.001), but in the phospholipidated curcumin group, elevation of PAB level was not significant (p=0.053). The results of our study did not suggest any improvement of PAB following supplementation with curcumin in MetS subjects. Copyright (c) 2017 John Wiley & Sons, Ltd.
C1 [Ghazimoradi, Maryam; Mohammadi, Farzane; Tavallaie, Shima; Safarian, Hamideh; Ghayour-Mobarhan, Majid; Esmaeili, Habibollah; Ahmadinejad, Malihe] Mashhad Univ Med Sci, Sch Med, Metab Syndrome Res Ctr, Mashhad, Iran.
   [Saberi-Karimian, Maryam] Mashhad Univ Med Sci, Sch Med, Dept Modern Sci & Technol, Student Res Comm, Mashhad, Iran.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Sch Pharm, Biotechnol Res Ctr, Mashhad, Iran.
   [Ferns, Gordon A.] Brighton & Sussex Med Sch, Div Med Educ, Brighton BN1 9PH, E Sussex, England.
   [Ghayour-Mobarhan, Majid; Moohebati, Mohsen] Mashhad Univ Med Sci, Sch Med, Cardiovasc Res Ctr, Mashhad, Iran.
   [Esmaeili, Habibollah] Mashhad Univ Med Sci, Sch Hlth, Dept Biostat, Mashhad, Iran.
C3 Mashhad University of Medical Sciences; Mashhad University of Medical
   Sciences; Mashhad University of Medical Sciences; University of Sussex;
   University of Brighton; Mashhad University of Medical Sciences; Mashhad
   University of Medical Sciences
RP Ghayour-Mobarhan, M (corresponding author), Mashhad Univ Med Sci, Sch Med, Metab Syndrome Res Ctr, Mashhad, Iran.; Sahebkar, A (corresponding author), Mashhad Univ Med Sci, Sch Med, Dept Biotechnol, Mashhad, Iran.
EM sahebkara@mums.ac.ir; ghayourm@mums.ac.ir
RI Ghayour-Mobarhan, Majid/AAY-5963-2020; mohebati, mohsen/AAR-2016-2021;
   ebrahimi, mansour/D-9950-2011; Sahebkar, Amirhossein/B-5124-2018;
   Esmaily, Habibollah/N-8264-2016; Mohammadi, Farzaneh/IYJ-7537-2023
OI Esmaily, Habibollah/0000-0003-4139-546X; Mohammadi,
   Farzaneh/0000-0002-0088-4729
FU Mashhad University of Medical Sciences
FX This research is financially supported by the Mashhad University of
   Medical Sciences.
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NR 37
TC 27
Z9 29
U1 1
U2 11
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0951-418X
EI 1099-1573
J9 PHYTOTHER RES
JI Phytother. Res.
PD NOV
PY 2017
VL 31
IS 11
BP 1715
EP 1721
DI 10.1002/ptr.5899
PG 7
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA FL9GV
UT WOS:000414562300009
PM 28840615
OA Bronze
DA 2025-06-11
ER

PT J
AU Wong, SK
   Chin, KY
   Suhaimi, FH
   Ahmad, F
   Ima-Nirwana, S
AF Wong, Sok Kuan
   Chin, Kok-Yong
   Suhaimi, Farihah Hj
   Ahmad, Fairus
   Ima-Nirwana, Soelaiman
TI Vitamin E As a Potential Interventional Treatment for Metabolic
   Syndrome: Evidence from Animal and Human Studies
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Review
DE vitamin E; tocopherol; tocotrienol; metabolic syndrome; obesity;
   hyperglycemia; hypertension; dyslipidemia
ID RICE BRAN OIL; ALPHA-TOCOPHEROL; OXIDATIVE STRESS; ANTIOXIDANT
   PROPERTIES; DOUBLE-BLIND; LIPID PARAMETERS; FRACTION SUPPLEMENTATION;
   INDUCED NEPHROPATHY; INSULIN-RESISTANCE; DELTA-TOCOTRIENOL
AB A constellation of medical conditions inclusive of central obesity, hyperglycemia, hypertension, and dyslipidemia is known as metabolic syndrome (MetS). The safest option in curtailing the progression of MetS is through maintaining a healthy lifestyle, which by itself, is a long-term commitment entailing much determination. A combination of pharmacological and non-pharmacological approach, as well as lifestyle modification is a more holistic alternative in the management of MetS. Vitamin E has been revealed to possess anti-oxidative, anti-inflammatory, anti-obesity, anti-hyperglycemic, anti-hypertensive and anti-hypercholesterolemic properties. The pathways regulated by vitamin E are critical in the development of MetS and its components. Therefore, we postulate that vitamin E may exert some health benefits on MetS patients. This review intends to summarize the evidence in animal and human studies on the effects of vitamin E and articulate the contrasting potential of tocopherol (TF) and tocotrienol (T3) in preventing the medical conditions associated with MetS. As a conclusion, this review suggests that vitamin E may be a promising agent for attenuating MetS.
C1 [Wong, Sok Kuan; Chin, Kok-Yong; Ima-Nirwana, Soelaiman] Univ Kebangsaan Malaysia, Fac Med, Dept Pharmacol, Cheras, Malaysia.
   [Suhaimi, Farihah Hj; Ahmad, Fairus] Univ Kebangsaan Malaysia, Fac Med, Dept Anat, Cheras, Malaysia.
C3 Universiti Kebangsaan Malaysia; Universiti Kebangsaan Malaysia
RP Ima-Nirwana, S (corresponding author), Univ Kebangsaan Malaysia, Fac Med, Dept Pharmacol, Cheras, Malaysia.
EM imasoel@ppukm.ukm.edu.my
RI Soelaiman, Ima/C-4289-2017; Chin, Kok-Yong/B-6309-2015; Wong, Sok
   Kuan/I-1243-2016
OI Ahmad, Fairus/0000-0002-2452-6459; Chin, Kok-Yong/0000-0001-6628-1552;
   Wong, Sok Kuan/0000-0003-1184-4551
FU Universiti Kebangsaan Malaysia via High Impact Research Grant
   [DIP-2014-040]; PPUKM Fundamental Grant [FF-2016-431]
FX We thank Universiti Kebangsaan Malaysia for funding the studies via High
   Impact Research Grant (DIP-2014-040) and PPUKM Fundamental Grant
   (FF-2016-431).
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NR 84
TC 89
Z9 90
U1 0
U2 23
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD JUL 5
PY 2017
VL 8
AR 444
DI 10.3389/fphar.2017.00444
PG 12
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA FB5CW
UT WOS:000406160100001
PM 28725195
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Fahmy, MIM
   Sayed, RH
   El-Yamany, MF
   El-Naggar, R
   Eliwa, HA
AF Fahmy, Mohamed Ibrahim Mohamed
   Sayed, Rabab Hamed
   El-Yamany, Muhammad Farag
   El-Naggar, Reham
   Eliwa, Hesham A.
TI Rosuvastatin and co-enzyme Q10 improve high-fat and
   high-fructose diet-induced metabolic syndrome in rats via ameliorating
   inflammatory and oxidative burden
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Article
DE Metabolic syndrome; Rosuvastatin; Co-enzyme Q10; HF-HFD; Oxidative
   stress; Inflammation
ID LOW-DENSITY-LIPOPROTEIN; STATIN-ASSOCIATED MYOPATHY; INSULIN-RESISTANCE;
   BLOOD-PRESSURE; MITOCHONDRIAL DYSFUNCTION; GLUCOSE-METABOLISM; GLYCEMIC
   CONTROL; SKELETAL-MUSCLE; LIVER-DISEASE; ANTIOXIDANT
AB The prevalence of metabolic syndrome (MetS) has been rising alarmingly and it has now become a global concern causing an enormous economic burden on the health care system. MetS is generally linked to complications in lipid metabolism, oxidative stress and low grade inflammation. The aim of the current study was to evaluate the effect of rosuvastatin, co-enzyme Q10 (CoQ10), and their combination on blood pressure, blood sugar, dyslipidemia, and liver function in rats with MetS induced by high fructose and high fat diet (HF-HFD) and the possible underlying mechanism. Oral administration of rosuvastatin (10 mg/kg/day), CoQ10 (10 mg/kg/ day) and their combination for 4 weeks in HF-HFD-fed rats elevated serum high density lipoprotein and reduced glutathione. On the other hand, treatment with rosuvastatin, CoQ10 or their combination decreased the serum levels of malondialdehyde, triglycerides, total cholesterol, and low density lipoprotein-cholesterol as well as systolic blood pressure, body weight and fasting blood glucose level. In addition, the drugs or their combination declined serum pro-inflammatory cytokines, namely tumor necrosis factor-alpha and interleukin-1 beta. In conclusion, our results showed that rosuvastatin or CoQ10 protected against HF-HFD-induced MetS through the regulation of dyslipidemia, elevated blood glucose, elevated blood pressure, antioxidant defenses and inflammatory response. Rosuvastatin or CoQ10 also alleviated the impairment of liver function that was induced by HF-HFD. Interestingly, CoQ10 augmented msuvastatin's effect in ameliorating MetS, via exerting synergistic modulatory effects on oxidative stress and inflammation. Thus, rosuvastatin and CoQ10 combination therapy may have possible applications in ameliorating metabolic disorders.
C1 [Fahmy, Mohamed Ibrahim Mohamed] Heliopolis Univ Sustainable Dev, Fac Pharm, Dept Pharmacol & Toxicol, Cairo, Egypt.
   [Sayed, Rabab Hamed; El-Yamany, Muhammad Farag] Cairo Univ, Fac Pharm, Dept Pharmacol & Toxicol, Giza, Egypt.
   [El-Naggar, Reham; Eliwa, Hesham A.] Misr Univ Sci & Technol MUST, Fac Pharm, Dept Pharmacol & Toxicol, Giza, Egypt.
C3 Egyptian Knowledge Bank (EKB); Heliopolis University; Egyptian Knowledge
   Bank (EKB); Cairo University; Egyptian Knowledge Bank (EKB); Misr
   University for Science & Technology
RP Sayed, RH (corresponding author), Fac Pharm, Kasr El Aini St, Cairo 11562, Egypt.
EM rabab.sayed@pharma.cu.edu.eg
RI , Rabab/I-2381-2019
OI , Rabab/0000-0002-5337-3658
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NR 90
TC 4
Z9 4
U1 1
U2 5
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD SEP
PY 2022
VL 153
AR 113526
DI 10.1016/j.biopha.2022.113526
EA AUG 2022
PG 10
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA 5J7KR
UT WOS:000869218700003
PM 36076607
OA gold
DA 2025-06-11
ER

PT J
AU Murase, T
   Hattori, T
   Ohtake, M
   Abe, M
   Amakusa, Y
   Takatsu, M
   Murohara, T
   Nagata, K
AF Murase, Tamayo
   Hattori, Takuya
   Ohtake, Masafumi
   Abe, Mayuna
   Amakusa, Yui
   Takatsu, Miwa
   Murohara, Toyoaki
   Nagata, Kohzo
TI Cardiac remodeling and diastolic dysfunction in
   DahlS.Z-Lepr<SUP>fa</SUP>/Lepr<SUP>fa</SUP> rats: a
   new animal model of metabolic syndrome
SO HYPERTENSION RESEARCH
LA English
DT Article
DE cardiac hypertrophy; diastolic dysfunction; metabolic syndrome;
   myocardial fibrosis; salt-sensitive hypertension
ID NECROSIS-FACTOR-ALPHA; SALT-SENSITIVE HYPERTENSION; HEART-FAILURE;
   OXIDATIVE STRESS; NADPH OXIDASE; II LEVELS; ACTIVATION; OBESITY;
   HYPERTROPHY; INFLAMMATION
AB We recently characterized male DahlS. Z-Lepr(fa)/Lepr(fa) (Dahl salt-sensitive (DS)/obese) rats, which were established from a cross between Dahl salt-sensitive and Zucker rats, as a new animal model of metabolic syndrome (MetS). We have now investigated cardiac pathophysiology and metabolic changes in female DS/obese rats in comparison with homozygous lean female littermates (DahlS. Z-Lepr(+)/Lepr(+), or DS/lean, rats). Animals were maintained on a normal diet and were subjected to echocardiography followed by various pathological analyses at 15 weeks of age. Systolic blood pressure was significantly higher in female DS/obese rats than in DS/lean females at 12 weeks of age and thereafter. The survival rate of DS/obese rats was significantly lower than that of DS/lean rats at 15 weeks. Body weight, as well as visceral and subcutaneous fat mass were significantly increased in DS/obese rats, which also manifested left ventricular (LV) diastolic dysfunction and marked LV hypertrophy and fibrosis. In addition, myocardial oxidative stress and inflammation were increased in DS/obese rats compared with DS/lean rats. Serum insulin and triglyceride levels as well as the ratio of low-density lipoprotein-to high-density lipoprotein-cholesterol levels were markedly elevated in DS/obese rats, whereas fasting serum glucose concentrations were similar in the two rat strains. The phenotype of female DS/obese rats is similar to that of MetS in humans. These animals also develop salt-sensitive hypertension and LV diastolic dysfunction as well as LV hypertrophy and fibrosis, and these changes are associated with increased cardiac oxidative stress and inflammation. Hypertension Research (2012) 35, 186-193; doi:10.1038/hr.2011.157; published online 15 September 2011
C1 [Nagata, Kohzo] Nagoya Univ, Dept Med Technol, Sch Hlth Sci, Higashi Ku, Nagoya, Aichi 4618673, Japan.
   [Murase, Tamayo; Hattori, Takuya; Ohtake, Masafumi; Takatsu, Miwa] Univ Grad Sch Med, Dept Pathophysiol Lab Sci, Nagoya, Aichi, Japan.
   [Murohara, Toyoaki] Nagoya Univ, Grad Sch Med, Dept Cardiol, Nagoya, Aichi 4618673, Japan.
C3 Nagoya University; Nagoya University
RP Nagata, K (corresponding author), Nagoya Univ, Dept Med Technol, Sch Hlth Sci, Higashi Ku, 1-1-20 Daikominami, Nagoya, Aichi 4618673, Japan.
EM nagata@met.nagoya-u.ac.jp
RI Murohara, Toyoaki/M-4958-2014
FU Mitsubishi Tanabe Pharma Corp. (Osaka, Japan); Kyowa Hakko Kirin Co Ltd
   (Tokyo, Japan); Japanese government
FX We thank Mayuko Furukawa, Koji Tsuboi, Yuichiro Yamada, Chisa Inoue,
   Tomomi Inoue, Haruka Tsukamoto, Masafumi Sakai and Chieko Nakashima for
   technical assistance. This work was supported by unrestricted research
   grants from the Mitsubishi Tanabe Pharma Corp. (Osaka, Japan) and Kyowa
   Hakko Kirin Co Ltd (Tokyo, Japan) as well as by Management Expenses
   Grants from the Japanese government to Nagoya University.
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NR 50
TC 58
Z9 65
U1 1
U2 9
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0916-9636
EI 1348-4214
J9 HYPERTENS RES
JI Hypertens. Res.
PD FEB
PY 2012
VL 35
IS 2
BP 186
EP 193
DI 10.1038/hr.2011.157
PG 8
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 892WJ
UT WOS:000300316000010
PM 21918527
OA Bronze
DA 2025-06-11
ER

PT J
AU Domingos, F
   Serra, A
AF Domingos, Fernando
   Serra, Adelaide
TI Metabolic syndrome: A multifaceted risk factor for kidney stones
SO SCANDINAVIAN JOURNAL OF UROLOGY
LA English
DT Review
DE hypertension; insulin resistance; metabolic syndrome; nephrolithiasis;
   obesity
ID INSULIN-RESISTANCE; CRYSTAL DEPOSITION; CALCIUM; ASSOCIATION; OXALATE;
   CITRATE; NEPHROLITHIASIS; HYPERTENSION; OVERWEIGHT; MORTALITY
AB Kidney stones and metabolic syndrome (MetS) are common conditions in industrialized countries. There is growing evidence of associations between kidney stone disease and MetS or some of its components. The link between uric acid stones and MetS is well understood, but the link with calcium oxalate (CaOx) stones, the most common kidney stone composition, is more complex, and MetS is frequently overlooked as a risk factor for calcium nephrolithiasis. The physiopathological mechanisms of kidney stone disease in MetS are reviewed in this article. Uric acid stones are a consequence of the excessively acidic urine that results from insulin resistance. The pathophysiology of CaOx stones may include: increased excretion of lithogenesis promoters and decreased excretion of inhibitors; increased risk of Randall's plaque development; and inflammatory damage to renal epithelia by oxidative stress, as a consequence of the insulin-resistant milieu that characterizes MetS. The last mechanism contributes to the adhesion of CaOx crystals to subepithelial calcium deposits working as anchor sites where stones can grow. The predominant MetS features could determine the chemical composition of the stones in each patient. Kidney stones may be a renal manifestation of MetS and features of this syndrome should be looked for in patients with idiopathic nephrolithiasis.
C1 [Domingos, Fernando] Univ Lisbon, Fac Med, Inst Physiol, P-1699 Lisbon, Portugal.
   [Domingos, Fernando; Serra, Adelaide] Hosp Fernando Fonseca, Serv Nephrol, Amadora, Portugal.
   [Serra, Adelaide] Hosp Fernando Fonseca, Outpatient Kidney Stone Clin, Amadora, Portugal.
C3 Universidade de Lisboa; Hospital Professor Doutor Fernando Fonseca, EPE;
   Hospital Professor Doutor Fernando Fonseca, EPE
RP Domingos, F (corresponding author), Hosp Prof Doutor Fernando Fonseca, Serv Nefrol, Estr IC 19, P-2720276 Amadora, Portugal.
EM fdomingos.nefrologia@gmail.com
RI Serra, Maria/G-2187-2012
OI Serra, Maria Adelaide/0000-0003-2332-0579
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NR 32
TC 31
Z9 33
U1 3
U2 24
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 2168-1805
EI 2168-1813
J9 SCAND J UROL
JI Scand. J. Urol.
PD OCT
PY 2014
VL 48
IS 5
BP 414
EP 419
DI 10.3109/21681805.2014.903513
PG 6
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA AP6SK
UT WOS:000342207700001
PM 24708398
DA 2025-06-11
ER

PT J
AU Bellon, A
   Nguyen, K
AF Bellon, Alfredo
   Kieuhanh Nguyen
TI Selective serotonin reuptake inhibitors and risk reduction for
   cardiovascular disease in patients with schizophrenia: A controversial
   but promising approach
SO WORLD JOURNAL OF PSYCHIATRY
LA English
DT Review
DE Antidepressants; Metabolic syndrome; Cholesterol; Psychotic disorders;
   Antipsychotics; Body weight
ID WEIGHT-GAIN; METABOLIC SYNDROME; CHOLESTEROL LEVELS; CORONARY EVENTS;
   DRUG-NAIVE; ASSOCIATION; DEPRESSION; MORBIDITY; MORTALITY; DISORDER
AB Patients with schizophrenia (SCZ) are at high risk of cardiovascular disease (CVD) due to an inherited predisposition, a sedentary life style and the use of antipsychotic medications. Several approaches have been taken to minimize this risk but results continue to be unsatisfactory. A potential alternative is prescribing selective serotonin reuptake inhibitors (SSRIs). SSRIs decrease platelet aggregation and reduce the risk of coronary heart disease in patients with depression. We therefore aim to investigate whether there is evidence that supports the use of SSRIs to reduce the risk for CVD in SCZ. A review of the literature revealed five published reports relating to the impact of SSRIs on CV risk in SCZ. Three trials assessed the influence on metabolic parameters of fluvoxamine when combined with clozapine. Two of those studies found improvements with fluvoxamine. Of the other two reports, one indicates SSRIs as a group caused minimal but statistically significant increments in total cholesterol, low-density lipoprotein and triglyceride. The second report suggests that when SSRIs are combined with antipsychotics, the metabolic impact depends on the antipsychotic prescribed. While there are promising results, no conclusions can be made currently on whether SSRIs increase or decrease CV risk in SCZ. Further studies are needed to resolve this matter.
C1 [Bellon, Alfredo] Penn State Hershey Med Ctr, Dept Psychiat & Behav Hlth, 500 Univ Dr, Hershey, PA 17033 USA.
   [Kieuhanh Nguyen] Penn State Hershey Med Ctr, Dept Penn State Coll Med, Hershey, PA 17033 USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE);
   Pennsylvania State University; Penn State Health; Pennsylvania
   Commonwealth System of Higher Education (PCSHE); Pennsylvania State
   University; Penn State Health
RP Bellon, A (corresponding author), Penn State Hershey Med Ctr, Dept Psychiat & Behav Hlth, 500 Univ Dr, Hershey, PA 17033 USA.
EM alfredobellon@yahoo.com
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NR 47
TC 7
Z9 8
U1 0
U2 2
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 7041 Koll Center Parkway, Suite 160, PLEASANTON, CA, UNITED STATES
SN 2220-3206
J9 WORLD J PSYCHIATR
JI World J. Psychiatr.
PD JUL 19
PY 2021
VL 11
IS 7
BP 316
EP 324
DI 10.5498/wjp.v11.i7.316
PG 9
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychiatry
GA TR0NY
UT WOS:000678671400005
PM 34327124
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Wang, W
   Peng, L
   Gao, XS
   Luo, DY
AF Wang, Wei
   Peng, Liao
   Gao, Xiaoshuai
   Luo, Deyi
TI The Frequency of Metabolic Syndrome in Aged Female Patients (Older Than
   65 Years) With and Without Stress Urinary Incontinence: A Case-Control
   Study
SO FEMALE PELVIC MEDICINE AND RECONSTRUCTIVE SURGERY
LA English
DT Article
DE metabolic syndrome; obesity; body mass index; stress urinary
   incontinence
ID QUALITY-OF-LIFE; TRACT SYMPTOMS; DIABETES-MELLITUS; RISK-FACTORS; WOMEN;
   ASSOCIATION; IMPACT; CHOLESTEROL; POPULATION; COMPONENTS
AB Objective The aim of the study was to assess the incidence of metabolic syndrome (MetS) in aged patients (older than 65 years) with and without stress urinary incontinence (SUI). Methods We evaluated the components of MetS in 460 SUI patients and 460 age-matched women without urinary incontinence from January 2009 to October 2019. Stress urinary incontinence was diagnosed by clinical complaint and the presence of involuntary urine leakage during physical activity. Definition of MetS was on the basis of the National Cholesterol Education Program Adult Treatment Panel III recommendations definition (NCEPATPIII) and the International Diabetes Federation criteria (IDF). Results Totally, 460 SUI patients with the median age of 70 years were eventually included in the study. Subsequently, 460 age-matched controls were selected. The prevalence of MetS was more frequent in SUI patients based on the NCEPATPIII (43.04% vs 19.78%, P < 0.0001) and IDF criteria (45.22% vs 20.22%, P < 0.0001). Moreover, logistic regression analysis revealed that MetS significantly increased the risk of SUI (odds ratio = 3.06, 95% confidence interval = 2.28-4.09) according to the NCEPATPIII definition and (odds ratio = 3.26, 95% confidence interval = 2.43-4.34) on the basis of IDF criteria compared with controls. Patients in the SUI group had a statistically higher body mass index (P < 0.0001), larger waist (P < 0.0001), higher level of fasting blood glucose (P = 0.0001), triglycerides (P = 0.00), and systolic blood pressure (P = 0.0001) than controls. Patients with SUI demonstrated a statistically worse symptom score in all aspects compared with controls (P < 0.0001). Conclusions The prevalence of MetS was higher in older women with SUI than in an age- and sex-matched control group without clinical SUI. Further studies are warranted to determine the pathophysiology mechanism of SUI and MetS.
C1 [Wang, Wei; Peng, Liao; Gao, Xiaoshuai; Luo, Deyi] Sichuan Univ, West China Hosp, Inst Urol, Dept Urol, Chengdu, Peoples R China.
C3 Sichuan University
RP Luo, DY (corresponding author), Sichuan Univ, West China Hosp, Inst Urol, Dept Urol, Chengdu, Peoples R China.
EM luodeyi@scu.edu.cn
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NR 30
TC 5
Z9 5
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 2151-8378
EI 2154-4212
J9 FEMALE PELVIC MED RE
JI Female Pelvic Med. Reconstr. Surg.
PD FEB
PY 2022
VL 28
IS 2
BP E11
EP E15
DI 10.1097/SPV.0000000000001122
PG 5
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA YN6PO
UT WOS:000747378800002
PM 34768259
DA 2025-06-11
ER

PT J
AU Bengesser, SA
   Lackner, N
   Birner, A
   Fellendorf, FT
   Platzer, M
   Mitteregger, A
   Unterweger, R
   Reininghaus, B
   Mangge, H
   Wallner-Liebmann, SJ
   Zelzer, S
   Fuchs, D
   McIntyre, RS
   Kapfhammer, HP
   Reininghaus, EZ
AF Bengesser, S. A.
   Lackner, N.
   Birner, A.
   Fellendorf, F. T.
   Platzer, M.
   Mitteregger, A.
   Unterweger, R.
   Reininghaus, B.
   Mangge, H.
   Wallner-Liebmann, S. J.
   Zelzer, S.
   Fuchs, D.
   McIntyre, R. S.
   Kapfhammer, H. P.
   Reininghaus, E. Z.
TI Peripheral markers of oxidative stress and antioxidative defense in
   euthymia of bipolar disorder-Gender and obesity effects
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Bipolar disorder; Oxidative stress; Antioxidants; Clutathione
   S-transferase; Malondiaidehyde; Total antioxidative capacity
ID GLUTATHIONE-S-TRANSFERASE; INDUCED LIPID-PEROXIDATION;
   SUPEROXIDE-DISMUTASE; METABOLIC SYNDROME; NITRIC-OXIDE; PROTEIN
   OXIDATION; INFLAMMATORY CYTOKINES; AUTOIMMUNE RESPONSES; PREFRONTAL
   CORTEX; MAJOR DEPRESSION
AB Introduction: Oxidative and nitrosative stress are implicated in the pathogenesis of uni- and bipolar disorder. Herein we primarily sought to characterize markers of oxidative/nitrosative stress during euthymia in adults with bipolar disorder (BD). Oxidative markers were further evaluated in this BD sample in synopsis with excess overweight or obesity and/or comorbid metabolic syndrome (MetS).
   Methods: Peripheral markers of oxidative stress [i.e thiobarbituric acid reactive substance, (TBARS), malondialdehycle (MDA), and carbonyl proteins] and antioxidant markers [e.g total antioxidative capacity (TAC), superoxide dismutase (SOD), glutathione S-transferase (GST)] were obtained in a cohort of euthymic adults with BD (N=113) and compared to healthy controls (CC) (N=78). Additionally, anthropometric measures included the body mass index (BMI) [kg/m(2)], waist and hip circumference [cm], waist-to-hip-ratio (WHR), waist to height ratio (WtHR) as well as the IDF-defined MetS.
   Results: The major finding was a significantly decreased TAC in BD compared to the CG (p < 0.01; BD: M 1.18, SD 0.47; CG: M 139, SD 0.49). MDA was significantly and TBARS by trend higher in the CG compared to the euthymic bipolar test persons (MDA: p < 0.01, BD: M 0.70, SD 0.18; CG: M 0.81, SD 025; TBARS: p<01, BD: M 0.78, SD 0.28; M 0.76, SD 0.30). The antioxidative enzyme CST was significantly elevated in both patients and controls (BD: M 298.24, SD 133.02; CC:: M 30727 SD 118.18). Subgroup analysis revealed that the CG with concurrent MetS and obesity had significantly elevated TAC when compared to CG without concurrent MetS < 0.05, no MetS: M 1.33, SD 0.50; MetS: M 1.67, SD 032), as well as persons with BD with or without current MetS (no MetS: M 1.18, SD 0.44; MetS: M 1.15, SD 0.49). Significant correlations between GST and anthropometric variables were found in male study participants. Multivariate analysis indicated a significant gender effect concerning TBARS values in all patients and CG (p < 0.01, females: M 0.73, SD 029; males: M 0.83, SD 0.28).
   Conclusion: Euthymic bipolar adults exhibit peripheral evidence of a disturbed biosignature of oxidative stress and antioxidative defense. Male test persons showed significantly higher peripheral markers of oxidative stress than women- female sex may exert protective effects. Furthermore, the biosignature of oxidative stress obtained herein was more pronounced in males with concurrent metabolic disorders. Our results further extend knowledge by introducing the moderating influence of gender and obesity on oxidative stress and BD. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Bengesser, S. A.; Lackner, N.; Birner, A.; Fellendorf, F. T.; Platzer, M.; Mitteregger, A.; Unterweger, R.; Reininghaus, B.; Kapfhammer, H. P.; Reininghaus, E. Z.] Med Graz Univ, Dept Psychiat, A-8036 Graz, Austria.
   [Wallner-Liebmann, S. J.] Inst Pathophysiol & Immunol, Graz, Austria.
   [Mangge, H.; Zelzer, S.] Clin Inst Med & Chem Lab Diagnost, Graz, Austria.
   [Fuchs, D.] Med Univ Innsbruck, Bioctr, Div Biol Chem, A-6020 Innsbruck, Austria.
   [McIntyre, R. S.] Univ Toronto, Univ Hlth Network, Mood Disorders Psychopharmacol Unit, Toronto, ON, Canada.
   [Reininghaus, B.] Therapiezentrum Justuspk, A-4540 Bad Hall, Austria.
C3 Medical University of Graz; Medical University of Innsbruck; University
   of Toronto; University Health Network Toronto
RP Lackner, N (corresponding author), Med Graz Univ, Dept Psychiat, Auenbruggerpl 31, A-8036 Graz, Austria.
EM Nina.Lackner@medunigraz.at
RI McIntyre, Roger/AAU-1000-2020; Fuchs, Dietmar/AAL-8011-2021
OI Mangge, Harald/0000-0003-4067-247X; Fellendorf,
   Frederike/0000-0001-7215-3848; Reininghaus, Eva/0000-0001-5964-4087
FU Stadt Graz
FX There are no conflicts of interests; we did not receive funding from
   companies (e.g, pharmaceutical industry). We received funding from
   "Stadt Graz",
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NR 79
TC 60
Z9 62
U1 2
U2 12
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD FEB 1
PY 2015
VL 172
BP 367
EP 374
DI 10.1016/j.jad.2014.10.014
PG 8
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA AX0LD
UT WOS:000346643000052
PM 25451439
DA 2025-06-11
ER

PT J
AU Gangel, MJ
   Dollar, J
   Brown, A
   Keane, S
   Calkins, SD
   Shanahan, L
   Wideman, L
AF Gangel, Meghan J.
   Dollar, Jessica
   Brown, Ashley
   Keane, Susan
   Calkins, Susan D.
   Shanahan, Lilly
   Wideman, Laurie
TI Childhood social preference and adolescent insulin resistance:
   Accounting for the indirect effects of obesity
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE Insulin resistance; Peer preference; Obesity
ID HOMEOSTASIS MODEL ASSESSMENT; BODY-MASS INDEX; TYPE-2 DIABETES-MELLITUS;
   WAIST CIRCUMFERENCE; CARDIOVASCULAR RISK; METABOLIC SYNDROME; CHILDREN;
   MECHANISMS; STRESS; SENSITIVITY
AB Insulin resistance, hyperinsulinemia, and Type II diabetes are increasingly common among young people in the United States. The quality of social relationships is a predictor of cardiometabolic health among adults, but has not been studied as a predictor of earlier insulin resistance. The purpose of this study was to test whether social preference (likeability) during childhood predicts insulin resistance and a measure of central adiposity during adolescence. Obesity also was examined as one mechanism through which this association occurs. Data came from a long-term longitudinal community study. At approximately age 7, 240 children were rated by their classmates on how liked and how disliked they were (difference score indexes social preference). Nine years later, at age 16, the same children visited the university laboratory where height, weight, and several measures of central adiposity (waist circumference, sagittal diameter, and waist-to-height ratio) were assessed by trained interviewers. Adolescents also provided fasted blood samples, from which HOMA-estimated insulin resistance was assessed. A path model yielded adequate to good fit indices, chi(2) (3, N = 240) = 6.689, p =.08, CFI =.97, RMSEA =.07 [95% CI =.00,.14], sRMR =.03. Results indicated that greater social preference at age 7 was significantly associated with lower IR at age 16. These findings suggest that children who are less liked by their classmates are more likely to demonstrate increased risk of IR. Additionally, BMI at age 15 was positively associated with both IR and WC at age 16. A bootstrapping procedure (10,000 draws) indicated that a child's likeability is associated with IR and WC through the association of likeability with later weight status. The quality of social relationships in childhood is important to consider when trying to understand the recent rise in adolescents' cardiometabolic risk and when considering intervention strategies.
C1 [Gangel, Meghan J.; Brown, Ashley; Keane, Susan] Univ North Carolina Greensboro, Dept Psychol, POB 26170, Greensboro, NC 27412 USA.
   [Dollar, Jessica; Calkins, Susan D.] Univ North Carolina Greensboro, Dept Human Dev & Family Studies, Greensboro, NC 27412 USA.
   [Shanahan, Lilly] Univ Zurich, Dept Psychol, Zurich, Switzerland.
   [Shanahan, Lilly] Univ Zurich, Jacobs Ctr Prod Youth Dev, Zurich, Switzerland.
   [Wideman, Laurie] Univ North Carolina Greensboro, Dept Kinesiol, Greensboro, NC 27412 USA.
C3 University of North Carolina; University of North Carolina Greensboro;
   University of North Carolina; University of North Carolina Greensboro;
   University of Zurich; University of Zurich; University of North
   Carolina; University of North Carolina Greensboro
RP Gangel, MJ (corresponding author), Univ North Carolina Greensboro, Dept Psychol, POB 26170, Greensboro, NC 27412 USA.
EM mjrose@uncg.edu
RI Shanahan, Lilly/HNJ-6173-2023; Keane, Susan/JFS-4254-2023
OI Shanahan, Lilly/0000-0002-4534-6924
FU Eunice Kennedy Shriver National Institute Of Child Health & Human
   Development of the National Institutes of Health [R01HD078346]; NIMH
   [55625]
FX Research reported in this publication was supported by the Eunice
   Kennedy Shriver National Institute Of Child Health & Human Development
   of the National Institutes of Health under Award Number R01HD078346.
   Support also came from NIMH 55625, NIMH
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NR 46
TC 8
Z9 10
U1 0
U2 6
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
EI 1873-3360
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD MAR
PY 2020
VL 113
AR 104557
DI 10.1016/j.psyneuen.2019.104557
PG 7
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA LD3MV
UT WOS:000525937600005
PM 31884323
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Niu, L
   Han, DW
   Xu, RL
   Han, B
   Zhou, X
   Wu, HW
   Li, SH
   Qu, CX
   Liu, M
AF Niu, L.
   Han, D. W.
   Xu, R. L.
   Han, B.
   Zhou, X.
   Wu, H. W.
   Li, S. H.
   Qu, C. X.
   Liu, M.
TI A high-sugar high-fat diet induced metabolic syndrome shows some
   symptoms of Alzheimer's disease in rats
SO JOURNAL OF NUTRITION HEALTH & AGING
LA English
DT Article
DE Metabolic syndrome; sporadic Alzheimer's disease; inflammation; insulin
   resistance; high-sugar high-fat
ID INSULIN-RESISTANCE; ASSOCIATION; MECHANISMS; STRESS; CELLS
AB Cases of sporadic Alzheimer's disease (SAD) are the predominant form of the age-related dementia. New evidence suggests that metabolic syndrome (MS), a metabolic disorder, is an initiating factor of some SAD cases. A high-sugar high-fat diet could cause MS, we aimed to investigate whether it could directly lead to SAD.
   The characteristic molecules of AD (hippocampus A beta and Tau) were tested by using ELISA and western blotting to confirm the happening hallmarks of AD in brain. MS and inflammation related biochemical indicators were measured using immunological method. Proteins associated with the insulin resistance signal pathway (JNK, PI-3K, AKT, GSK-3 beta, GLUT3) were evaluated using western blotting method. The levels of reactive oxygen species (ROS) were measured by immunofluorescence method.
   Expressions of hippocampus A beta, phosphorylation-Tau (p-Tau), inflammatory factors and p-JNK, Gsk-3 beta were higher in the model rats than those in the control rats and expressions of p-PI3K, p-AKT and GLUT3 were reversed.
   The MS model animals, which can induce the characteristics symptoms of AD, and therefore it may be preliminarily considered that the AD pertains to the MS-related diseases.
C1 [Niu, L.; Han, D. W.; Zhou, X.] Shanxi Med Univ, Sch Basic Med Sci, Wuhan, Peoples R China.
   [Niu, L.; Han, D. W.; Xu, R. L.; Zhou, X.] Shanxi Med Univ, Inst Liver Dis, New South Rd 56, Taiyuan 030001, Shanxi, Peoples R China.
   [Han, B.] Shanxi Med Univ, Hosp 1, Dept Mental Hlth, Wuhan 030001, Peoples R China.
   [Wu, H. W.] Shanxi Med Univ, Res Ctr, Fenyang Coll, Fenyang 032299, Peoples R China.
   [Li, S. H.] Shanxi Prov Tumor Hosp, Dept Pathol, Taiyuan 030013, Peoples R China.
   [Qu, C. X.] Peoples Hosp Shanxi Prov, Dept Pathol, Taiyuan 030012, Peoples R China.
   [Liu, M.] Shanxi Med Univ, Sch Basic Med Sci, Taiyuan 030001, Peoples R China.
C3 Shanxi Medical University; Shanxi Medical University; Shanxi Medical
   University; Shanxi Medical University; Shanxi People's Hospital; Shanxi
   Medical University
RP Han, DW (corresponding author), Shanxi Med Univ, Inst Liver Dis, New South Rd 56, Taiyuan 030001, Shanxi, Peoples R China.
EM nltys2004@163.com
FU natural science foundation of China [81302220]; Scientific and
   technological project of Shanxi Province [2014021040-3, 2014021037-1]
FX This study was supported by the the natural science foundation of China.
   (Grant No. 81302220) and Scientific and technological project of Shanxi
   Province. (Grant No. 2014021040-3, No. 2014021037-1). The Corresponding
   Authors have the right to grant on behalf of all authors and does grant
   on behalf of all authors. The manuscript has not been published
   elsewhere and has not been submitted simultaneously for publication
   elsewhere. All study participants provided informed consent, and the
   study design was approved by the appropriate ethics review boards. All
   the authors have approved the manuscript and agree with submission to
   your esteemed journal. There are no conflicts of interest to declare. An
   exclusive license (or non exclusive for government employees) on a
   worldwide basis to the Elsevier to permit this article (if accepted) to
   be published in The journal of nutrition, health & aging and sublicenses
   such use and exploit all subsidiary rights, as set out in our license.
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NR 35
TC 36
Z9 38
U1 3
U2 24
PU SPRINGER FRANCE
PI PARIS
PA 22 RUE DE PALESTRO, PARIS, 75002, FRANCE
SN 1279-7707
EI 1760-4788
J9 J NUTR HEALTH AGING
JI J. Nutr. Health Aging
PD MAY
PY 2016
VL 20
IS 5
BP 509
EP 513
DI 10.1007/s12603-015-0601-1
PG 5
WC Geriatrics & Gerontology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology; Nutrition & Dietetics
GA DM4BA
UT WOS:000376289300007
PM 27102788
OA hybrid
DA 2025-06-11
ER

PT J
AU Baranowska, B
   Kochanowski, J
   Grudniak, M
   Wolinska-Witort, E
   Kalisz, M
   Bik, W
AF Baranowska, Boguslawa
   Kochanowski, Jan
   Grudniak, Mariusz
   Wolinska-Witort, Ewa
   Kalisz, Malgorzata
   Bik, Wojciech
TI Plasma NPY concentrations in women with acute ischemic stroke
SO NEUROENDOCRINOLOGY LETTERS
LA English
DT Article
DE NPY; acute ischemic stroke
ID Y-RECEPTOR SUBTYPES; NEUROPEPTIDE-Y; METABOLIC SYNDROME; BRAIN PEPTIDE;
   OBESE WOMEN; STRESS; LEPTIN; INSULIN; GALANIN; HYPERTENSION
AB OBJECTIVE: It has been reported that plasma NPY levels were increased in obesity, type 2 diabetes mellitus and hypertension. The symptoms of metabolic syndrome frequently appear in patients with acute ischemic stroke. The association between plasma NPY levels and metabolic markers in women with acute ischemic stroke was investigated in the current study.
   METHODS: Plasma NPY concentrations were determined using radioimmunoassay in 58 women aged 60-85 (mean age: 76.5 +/- 0.8) with acute ischemic stroke and in 24 women aged 63-67 (mean age: 65.6 +/- 0.6) of the control group. Stroke was defined according to the NIHSS (National Institute of Health Stroke Scale) and was confirmed using CT or MR scan.
   RESULTS: The prevalence of type 2 diabetes, hypertension and insulin resistance was higher in the group of patients with stroke. Plasma NPY levels measured during the 1st day and 10 days after the acute phase of stroke were significantly lower (p<0.001) compared to the control group.
   CONCLUSION: In women with acute ischemic stroke plasma NPY concentrations were decreased in spite of higher frequency of the occurrence of the symptoms of metabolic syndrome.
C1 [Baranowska, Boguslawa] Med Ctr Postgrad Educ, Dept Clin Physiol, PL-01813 Warsaw, Poland.
   [Kochanowski, Jan; Grudniak, Mariusz] Med Univ Warsaw, Dept Neurol, Warsaw, Poland.
   [Wolinska-Witort, Ewa; Kalisz, Malgorzata; Bik, Wojciech] Med Ctr Postgrad Educ, Dept Neuroendocrinol, PL-01813 Warsaw, Poland.
C3 Centre of Postgraduate Medical Education - Poland; Medical University of
   Warsaw; Centre of Postgraduate Medical Education - Poland
RP Baranowska, B (corresponding author), Med Ctr Postgrad Educ, Dept Neuroendocrinol, Dept Clin Physiol, Marymoncka 99-103, PL-01813 Warsaw, Poland.
EM zncmkp@op.pl
RI Bik, Wojciech/S-3755-2019
OI Bik, Wojciech/0000-0001-5925-8573; Kochanowski, Jan/0000-0003-0263-2274;
   Kalisz, Malgorzata/0000-0003-3060-1141
FU scientific grant NCN [5484/B/P01/2011/40]
FX This work was supported by scientific grant NCN No. 5484/B/P01/2011/40.
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NR 44
TC 8
Z9 11
U1 0
U2 4
PU MAGHIRA & MAAS PUBLICATIONS
PI STOCKHOLM
PA PO BOX 26132, S-100 41 STOCKHOLM, SWEDEN
SN 0172-780X
J9 NEUROENDOCRINOL LETT
JI Neuroendocrinol. Lett.
PY 2013
VL 34
IS 2
BP 124
EP 128
PG 5
WC Endocrinology & Metabolism; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology
GA AA2AZ
UT WOS:000330898800007
PM 23645309
DA 2025-06-11
ER

PT J
AU Xie, YD
   Yang, YP
   Li, S
   Xu, YH
   Lu, WF
   Chen, ZZ
   Yang, GD
   Li, YP
   Cao, YX
   Bian, XL
AF Xie, Yundong
   Yang, Yaping
   Li, Sen
   Xu, Yanhong
   Lu, Wenfang
   Chen, Zizhang
   Yang, Guangde
   Li, Yiping
   Cao, Yongxiao
   Bian, Xiaoli
TI Phenylsulfonylfuroxan NO-donor phenols: Synthesis and multifunctional
   activities evaluation
SO BIOORGANIC & MEDICINAL CHEMISTRY
LA English
DT Article
DE Phenylsulfonyfuroxan; Antioxidant; Yeast alpha-glucosidase;
   Anti-glycosylation; Anti-platelet aggregation; Vasodilatation; Metabolic
   syndrome
ID NITRIC-OXIDE; METABOLIC SYNDROME; OXIDATIVE STRESS; ANTIGLYCATION
   PROPERTIES; BIOLOGICAL EVALUATION; ANTIOXIDANT STATUS; GREEN TEA;
   INFLAMMATION; DERIVATIVES; ATHEROSCLEROSIS
AB Phenylsulfonyfuroxan nitric oxide (NO)-donor phenols were designed, synthesized and evaluated. The compounds were designed through a symbiotic approach using selected phenols and phenylsulfonylfuroxan NO-donor. The antioxidant activities of the hybrid compounds T-2-T-6 showed to be good in vivo. Compounds T-4 and T-6 revealed excellent yeast alpha-glucosidase inhibitory activity and anti-glycosylation activity. All of the compounds exhibited strong NO releasing activity and significant anti-platelet aggregation activity. The inhibition of platelet aggregation was more than 50% at low concentration (1.5 mu M) and 95% at higher concentration (15 mu M and 150 mu M). The vasodilatation experiment demonstrated that the six compounds under test exhibited definite vasodilation activity (pIC(50) ranged from 5.698 to 6.383), especially compound T6 (pIC(50) was 6.383) which was similar to sodium nitroprusside (pIC(50) was 6.786). Both anticoagulant and vasodilatation effects were correlated with their NO releasing activities. These hybrid phenylsulfonyfuroxan-based NO-donor phenols offer a multifunctional prodrug design concept for the development of therapeutic or preventive agents for metabolic syndrome. (C) 2017 Published by Elsevier Ltd.
C1 [Xie, Yundong; Yang, Yaping; Xu, Yanhong; Lu, Wenfang; Chen, Zizhang; Yang, Guangde; Li, Yiping; Bian, Xiaoli] Xi An Jiao Tong Univ, Coll Pharm, 76 Yanta West Rd, Xian 710061, Shaanxi, Peoples R China.
   [Li, Sen; Cao, Yongxiao] Xi An Jiao Tong Univ, Sch Basic Med Sci, 76 Yanta West Rd, Xian 710061, Shaanxi, Peoples R China.
C3 Xi'an Jiaotong University; Xi'an Jiaotong University
RP Bian, XL (corresponding author), Xi An Jiao Tong Univ, Coll Pharm, 76 Yanta West Rd, Xian 710061, Shaanxi, Peoples R China.
EM xieshijiaoda405@stu.xjtu.edu.cn
RI Xie, Yundong/MVX-4149-2025; LI, SEN/LMM-9462-2024
FU National Natural Science Foundation of China [21172177]
FX This work was supported by the National Natural Science Foundation of
   China (Grant No. 21172177).
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NR 34
TC 10
Z9 10
U1 2
U2 18
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0968-0896
EI 1464-3391
J9 BIOORGAN MED CHEM
JI Bioorg. Med. Chem.
PD AUG 15
PY 2017
VL 25
IS 16
BP 4407
EP 4413
DI 10.1016/j.bmc.2017.06.023
PG 7
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Chemistry,
   Organic
WE Science Citation Index Expanded (SCI-EXPANDED); Index Chemicus (IC)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Chemistry
GA FB3DO
UT WOS:000406023000018
PM 28651914
DA 2025-06-11
ER

PT J
AU Saban-Ruiz, J
   Ly-Pen, D
AF Saban-Ruiz, J.
   Ly-Pen, D.
TI COVID-19: A Personalized Cardiometabolic Approach for Reducing
   Complications and Costs. The Role of Aging Beyond Topics
SO JOURNAL OF NUTRITION HEALTH & AGING
LA English
DT Article
DE Metabolic Syndrome; cardiometabolic syndrome; cardiometabolic risk;
   cardiometabolic health; atherothrombotic disease; endothelial
   dysfunction
ID CONGESTIVE-HEART-FAILURE; EXPERIMENTAL-MODEL; SARS CORONAVIRUS;
   MANAGEMENT; RECEPTOR; PROTEIN; ACE2; INFECTIONS; SYSTEMS; HEALTH
AB COVID 19 is much more than an infectious disease by SARS-CoV-2 followed by a disproportionate immune response. An older age, diabetes and history of cardiovascular disease, especially hypertension, but also chronic heart failure and coronary artery disease among others, are between the most important risk factors. In addition, during the hospitalization both hyperglycaemia and heart failure are frequent. Less frequent are acute coronary syndrome, arrhythmias and stroke. Accordingly, not all prolonged stays or even deaths are due directly to SARS-CoV-2. To our knowledge, this is the first review, focusing both on cardiovascular and metabolic aspects of this dreadful disease, in an integrated and personalized way, following the guidelines of the Cardiometabolic Health/Medicine. Therefore, current personalized aspects such as ACEIs and ARBs, the place of statins and the most appropriate management of heart failure in diabetics are analysed. Aging, better than old age, as a dynamic process, is also considered in this review for the first time in the literature, and not only as a risk factor attributed to cardiovascular and non-cardiovascular comorbidities. Immunosenescence is also approached to build healthier elders, so they can resist present and future infectious diseases, and not only in epidemics or pandemics. In addition, to do this we must start knowing the molecular mechanisms that underlying Aging process in general, and immunosenescence in particular. Surprisingly, the endoplasmic reticulum stress and autophagy are implicated in both process. Finally, with a training in all the aspects covered in this review, not only the hospital stay, complications and costs of this frightening disease in high-risk population should be reduced. Likely, this paper will open a gate to the future for open-minded physicians.
C1 [Saban-Ruiz, J.] D Med Clin, Antiaging & Cardiometab Hlth Unit, Madrid, Spain.
   [Saban-Ruiz, J.] Helicopteros Sanitarios Hosp, Marbella, Spain.
   [Saban-Ruiz, J.] Int Med Acad IMA, Costa Del Sol, Spain.
   [Ly-Pen, D.] Abbey House Med Ctr, Navan, Co Meath, Ireland.
RP Saban-Ruiz, J (corresponding author), D Med Clin, Madrid, Spain.
EM psaban@gmail.com
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NR 88
TC 10
Z9 10
U1 0
U2 6
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1279-7707
EI 1760-4788
J9 J NUTR HEALTH AGING
JI J. Nutr. Health Aging
PD JUN
PY 2020
VL 24
IS 6
BP 550
EP 559
DI 10.1007/s12603-020-1385-5
EA MAY 2020
PG 10
WC Geriatrics & Gerontology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology; Nutrition & Dietetics
GA LV8QD
UT WOS:000532083400005
PM 32510105
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Nasi, M
   Patrizi, G
   Pizzi, C
   Landolfo, M
   Boriani, G
   Dei Cas, A
   Cicero, AFG
   Fogacci, F
   Rapezzi, C
   Sisca, G
   Capucci, A
   Vitolo, M
   Galiè, N
   Borghi, C
   Berrettini, U
   Piepoli, M
   Mattioli, AV
AF Nasi, Milena
   Patrizi, Giampiero
   Pizzi, Carmine
   Landolfo, Matteo
   Boriani, Giuseppe
   Dei Cas, Alessandra
   Cicero, Arrigo F. G.
   Fogacci, Federica
   Rapezzi, Claudio
   Sisca, Giovanbattista
   Capucci, Alessandro
   Vitolo, Marco
   Galie, Nazzareno
   Borghi, Claudio
   Berrettini, Umberto
   Piepoli, Massimo
   Mattioli, Anna V.
TI The role of physical activity in individuals with cardiovascular risk
   factors: an opinion paper from Italian Society of Cardiology-Emilia
   Romagna-Marche and SIC-Sport
SO JOURNAL OF CARDIOVASCULAR MEDICINE
LA English
DT Review
DE cardiovascular risk factors; diabetes; hypertension; physical activity;
   uric acid
ID SERUM URIC-ACID; BLOOD-PRESSURE; AEROBIC EXERCISE; WEIGHT-LOSS;
   ENDOTHELIAL FUNCTION; DISEASE; MORTALITY; OBESITY; METAANALYSIS;
   POPULATION
AB Regular physical activity is a cornerstone in the prevention and treatment of atherosclerotic cardiovascular disease (CVD) due to its positive effects in reducing several cardiovascular risk factors. Current guidelines on CVD suggest for healthy adults to perform at least 150 min/week of moderate intensity or 75 min/week of vigorous intensity aerobic physical activity. The current review explores the effects of physical activity on some risk factors, specifically: diabetes, dyslipidemia, hypertension and hyperuricemia. Physical activity induces an improvement in insulin sensitivity and in glucose control independently of weight loss, which may further contribute to ameliorate both diabetes-associated defects. The benefits of adherence to physical activity have recently proven to extend beyond surrogate markers of metabolic syndrome and diabetes by reducing hard endpoints such as mortality. In recent years, obesity has greatly increased in all countries. Weight losses in these patients have been associated with improvements in many cardiometabolic risk factors. Strategies against obesity included caloric restriction, however greater results have been obtained with association of diet and physical activity. Similarly, the beneficial effect of training on blood pressure via its action on sympathetic activity and on other factors such as improvement of endothelial function and reduction of oxidative stress can have played a role in preventing hypertension development in active subjects. The main international guidelines on prevention of CVD suggest to encourage and to increase physical activity to improve lipid pattern, hypertension and others cardiovascular risk factor. An active action is required to the National Society of Cardiology together with the Italian Society of Sports Cardiology to improve the prescription of organized physical activity in patients with CVD and/or cardiovascular risk factors.
C1 [Nasi, Milena; Mattioli, Anna V.] Univ Modena & Reggio Emilia, Dept Surg Med & Dent, Dept Morphol Sci Related Transplant Oncol & Regen, Modena, Italy.
   [Patrizi, Giampiero] Carpi Hosp, Dept Cardiol, Carpi, Italy.
   [Pizzi, Carmine; Rapezzi, Claudio; Galie, Nazzareno] Alma Mater Studiorum, Dept Expt Diagnost & Specialty Med DIMES, Bologna, Italy.
   [Landolfo, Matteo; Cicero, Arrigo F. G.; Fogacci, Federica; Borghi, Claudio] Univ Bologna, Dept Med & Surg Sci, Bologna, Italy.
   [Boriani, Giuseppe; Vitolo, Marco] Univ Modena & Reggio Emilia, Dept Biomed Metab & Neural Sci, Div Cardiol, Modena, Italy.
   [Dei Cas, Alessandra] Univ Parma, Dept Clin & Expt Med, Endocrinol & Metab, Parma, Italy.
   [Sisca, Giovanbattista] Bologna FC, Bologna, Italy.
   [Sisca, Giovanbattista] Isokinet Med Grp, FIFA Med Ctr Excellence, Bologna, Italy.
   [Capucci, Alessandro] Marche Polytech Univ, Ancona, Italy.
   [Berrettini, Umberto] Camerino Hosp, Dept Cardiol, Camerino, Italy.
   [Piepoli, Massimo] Guglielmo da Saliceto Hosp, Heart Failure Unit, Cardiol, Piacenza, Italy.
C3 Universita di Modena e Reggio Emilia; University of Bologna; Universita
   di Modena e Reggio Emilia; University of Parma; University Hospital of
   Parma; Marche Polytechnic University; Guglielmo da Saliceto Hospital
RP Mattioli, AV (corresponding author), Univ Modena & Reggio Emilia, Dept Surg Med Dent & Morphol Sci, Cardiovasc Dis, Via Pozzo 71, I-41124 Modena, Italy.
EM annavittoria.mattioli@unimore.it
RI Vitolo, Marco/W-1038-2019; Cicero, Arrigo/H-8244-2019; Nasi,
   Milena/J-4425-2016; Landolfo, Matteo/MHQ-2733-2025; Boriani,
   Giuseppe/AAC-3406-2022; PIZZI, Carmine/C-8394-2012; Fogacci,
   Federica/R-5931-2016; BORIANI, GIUSEPPE/A-4852-2015; Mattioli, Anna
   Vittoria/G-6001-2012; Piepoli, Massimo/J-9437-2016
OI BORIANI, GIUSEPPE/0000-0002-9820-4815; Mattioli, Anna
   Vittoria/0000-0003-1487-9530; Vitolo, Marco/0000-0002-5196-6249;
   Landolfo, Matteo/0000-0002-2087-2573; Pizzi,
   Carmine/0000-0002-4048-675X; Piepoli, Massimo/0000-0003-1124-234X;
   Cicero, Arrigo Francesco Giuseppe/0000-0002-4367-3884; Dei Cas,
   Alessandra/0000-0002-8666-4849
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NR 87
TC 50
Z9 50
U1 1
U2 31
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1558-2027
EI 1558-2035
J9 J CARDIOVASC MED
JI J. Cardiovasc. Med.
PD OCT
PY 2019
VL 20
IS 10
BP 631
EP 639
DI 10.2459/JCM.0000000000000855
PG 9
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA IX2UB
UT WOS:000485543800002
PM 31436678
DA 2025-06-11
ER

PT J
AU Sharma, H
   Chandola, HM
AF Sharma, Hari
   Chandola, H. M.
TI Prameha in Ayurveda: Correlation with Obesity, Metabolic
   Syndrome, and Diabetes Mellitus. Part 2-Management of Prameha
SO JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE
LA English
DT Article
ID ENICOSTEMMA-LITTORALE BLUME; TINOSPORA-CORDIFOLIA ROOTS; INDIAN
   MEDICINAL-PLANTS; TURMERIC CURCUMA-LONGA; GARLIC POWDER TABLETS;
   BLOOD-GLUCOSE LEVEL; GYMNEMA-SYLVESTRE; OXIDATIVE STRESS;
   MOMORDICA-CHARANTIA; AQUEOUS EXTRACT
AB Background: Obesity, metabolic syndrome, and diabetes mellitus are increasing to epidemic proportions globally. Prameha is a syndrome described in the ancient Ayurvedic texts that includes clinical conditions involved in obesity, prediabetes, diabetes mellitus, and metabolic syndrome.
   Materials and methods: Various dietary, lifestyle, and psychologic factors are involved in the etiology of Prameha, particularly in relation to disturbances in fat and carbohydrate metabolism.
   Results: The Ayurvedic management of Prameha emphasizes dietary and lifestyle recommendations and herbal preparations, in accordance with the psychophysiologic constitution of the patient. Ayurveda also addresses the management of psychologic factors that contribute to the development of Prameha. Ayurvedic treatment known as Apatarpana (balanced diet with restricted calories) and Santarpana (highly nutritious, high-calorie diet intended to increase weight) are recommended for patients with type 2 and type 1 diabetes, respectively. Various Ayurvedic herbs and herbomineral formulations are utilized, based on the stage and type of disease as well as the psychophysiologic constitution of the patient. A large body of research has been conducted on these Ayurvedic herbs.
   Conclusions: Integrating the theory and modalities of Ayurveda in the management of these disorders may prove to be beneficial.
C1 [Sharma, Hari] Ohio State Univ, Coll Med, Ctr Integrat Med, Columbus, OH 43221 USA.
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   [Chandola, H. M.] Gujarat Ayurved Univ, Inst Postgrad Teaching & Res Ayurveda, Jamnagar, India.
C3 University System of Ohio; Ohio State University; University System of
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RP Sharma, H (corresponding author), Ohio State Univ, Coll Med, Ctr Integrat Med, 2000 Kenny Rd, Columbus, OH 43221 USA.
EM sharma.2@osu.edu
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NR 153
TC 7
Z9 7
U1 0
U2 16
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1075-5535
EI 1557-7708
J9 J ALTERN COMPLEM MED
JI J. Altern. Complement Med.
PD JUL
PY 2011
VL 17
IS 7
BP 589
EP 599
DI 10.1089/acm.2010.0397
PG 11
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA 784UL
UT WOS:000292183600004
PM 21668351
DA 2025-06-11
ER

PT J
AU Orqueda, ME
   Rivas, M
   Zampini, IC
   Alberto, MR
   Torres, S
   Cuello, S
   Sayago, J
   Thomas-Valdes, S
   Jiménez-Aspee, F
   Schmeda-Hirschmann, G
   Isla, MI
AF Eugenia Orqueda, Maria
   Rivas, Marisa
   Catiana Zampini, Iris
   Rosa Alberto, Maria
   Torres, Sebastian
   Cuello, Soledad
   Sayago, Jorge
   Thomas-Valdes, Samanta
   Jimenez-Aspee, Felipe
   Schmeda-Hirschmann, Guillermo
   Ines Isla, Maria
TI Chemical and functional characterization of seed, pulp and skin powder
   from chilto (Solanum betaceum), an Argentine native fruit.
   Phenolic fractions affect key enzymes involved in metabolic syndrome and
   oxidative stress
SO FOOD CHEMISTRY
LA English
DT Article
DE Solanum betaceum; Chilto; Seed, pulp and skin powder; Antioxidant
   capacity; Metabolic syndrome
ID ANTIOXIDANT ACTIVITY; GEOFFROEA-DECORTICANS; TEA POLYPHENOLS; VITAMIN-C;
   IN-VITRO; TOMATO; CAV.; INHIBITORS; FLAVONOIDS; ANTHOCYANINS
AB The aim of this work was to assess the nutritional and functional components of powder obtained by lyophilization of whole fruits, seeds, pulp and skin from chilto (Solanum betaceum Cav) cultivated in the ecoregion of Yungas, Argentina. The powders have low carbohydrate and sodium content and are a source of vitamin C, carotenoid, phenolics, potassium and fiber. The HPLC-ESI-MS/MS analysis of the fractions enriched in phenolics allowed the identification of 12 caffeic acid derivatives and related phenolics, 10 rosmarinic acid derivatives and 7 flavonoids. The polyphenols enriched extracts before and after simulated gastroduodenal digestion inhibited enzymes associated with metabolic syndrome, including alpha-glucosidase, amylase and lipase and exhibited antioxidant activity by different mechanisms. None of the analyzed fruit powders showed acute toxicity or genotoxicity. The powders from the three parts of S. betaceum fruit may be a potential functional food and the polyphenol enriched extract of seed and skin may have nutraceutical properties. (C) 2016 Elsevier Ltd. All rights reserved.
C1 [Eugenia Orqueda, Maria; Rivas, Marisa; Catiana Zampini, Iris; Rosa Alberto, Maria; Torres, Sebastian; Cuello, Soledad; Sayago, Jorge; Ines Isla, Maria] Univ Nacl Tucuman, Fac Ciencias Nat, Inst Quim NOA INQUINOA CONICET, Lab Invest Prod Nat LIPRON, San Miguel De Tucuman, Argentina.
   [Eugenia Orqueda, Maria; Rivas, Marisa; Catiana Zampini, Iris; Rosa Alberto, Maria; Torres, Sebastian; Cuello, Soledad; Sayago, Jorge; Ines Isla, Maria] Univ Nacl Tucuman, IML, San Miguel De Tucuman, Argentina.
   [Thomas-Valdes, Samanta; Jimenez-Aspee, Felipe; Schmeda-Hirschmann, Guillermo] Univ Talca, Inst Quim Recursos Nat, Lab Quim Prod Nat, Casilla 747, Talca 3460000, Chile.
C3 Universidad Nacional de Tucuman; Universidad Nacional de Tucuman;
   Universidad de Talca
RP Isla, MI (corresponding author), Univ Nacl Tucuman, INQUINOA CONICET, San Lorenzo 1469, RA-4000 San Miguel De Tucuman, Tucuman, Argentina.
EM misla@tucbbs.com.ar
RI Torres, Sebastian/AAE-4510-2020; Thomas-Valdés, Samanta/H-4807-2018;
   Alberto, Maria Rosa/AAS-3062-2021; Sayago, Jorge/AAD-3546-2021; Schmeda
   Hirschmann, Guillermo/G-1046-2010; Jimenez Aspee, Felipe/G-6955-2017
OI Schmeda Hirschmann, Guillermo/0000-0002-9228-5378; Alberto, Maria
   Rosa/0000-0002-4173-9499; TORRES, Sebastian/0000-0002-3593-831X; Jimenez
   Aspee, Felipe/0000-0002-7285-7033
FU ARCOR Award to Technological Innovation (Argentina); Secretaria de
   Ciencia, Arte e Innovacion Tecnologica de la Universidad Nacional de
   Tucuman, Argentina (SCAIT-UNT); Consejo Nacional de Investigaciones
   Cientificas y Tecnicas, Argentina (CONICET); Agencia Nacional de
   Promocion Cientifica y Tecnologica, Argentina (ANPCyT); FONDECYT (Chile)
   [1120096]; PIEI-QUIM-BIO, Universidad de Talca
FX This research was supported by grants from: ARCOR Award to Technological
   Innovation (Argentina) in Edition 2015, Secretaria de Ciencia, Arte e
   Innovacion Tecnologica de la Universidad Nacional de Tucuman, Argentina
   (SCAIT-UNT), Consejo Nacional de Investigaciones Cientificas y Tecnicas,
   Argentina (CONICET), Agencia Nacional de Promocion Cientifica y
   Tecnologica, Argentina (ANPCyT), FONDECYT 1120096 (Chile) and
   PIEI-QUIM-BIO, Universidad de Talca.
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NR 57
TC 47
Z9 50
U1 2
U2 149
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0308-8146
EI 1873-7072
J9 FOOD CHEM
JI Food Chem.
PD FEB 1
PY 2017
VL 216
BP 70
EP 79
DI 10.1016/j.foodchem.2016.08.015
PG 10
WC Chemistry, Applied; Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Food Science & Technology; Nutrition & Dietetics
GA DY0JO
UT WOS:000384783300010
PM 27596394
OA Green Published
DA 2025-06-11
ER

PT J
AU Murase, T
   Hattori, T
   Ohtake, M
   Nakashima, C
   Takatsu, M
   Murohara, T
   Nagata, K
AF Murase, Tamayo
   Hattori, Takuya
   Ohtake, Masafumi
   Nakashima, Chieko
   Takatsu, Miwa
   Murohara, Toyoaki
   Nagata, Kohzo
TI Effects of Estrogen on Cardiovascular Injury in Ovariectomized Female
   DahlS.Z-Lepr<SUP>fa</SUP>/Lepr<SUP>fa</SUP> Rats as a New
   Animal Model of Metabolic Syndrome
SO HYPERTENSION
LA English
DT Article
DE metabolic syndrome; estrogen; hypertension; myocardial fibrosis;
   diastolic dysfunction; oxidative stress; inflammation
ID ATTENUATES CARDIAC-HYPERTROPHY; LEFT-VENTRICULAR GEOMETRY;
   RENIN-ANGIOTENSIN SYSTEM; HEART-FAILURE; OXIDATIVE STRESS;
   BLOOD-PRESSURE; DIASTOLIC DYSFUNCTION; REPLACEMENT THERAPY; TYPE-1
   RECEPTOR; PLUS PROGESTIN
AB Although recent clinical trials have found an increased incidence of cardiovascular disease in women on estrogen replacement therapy, the underlying mechanism remains unclear. We have recently characterized DahlS.Z-Lepr(fa)/Lepr(fa) (DS/obese) rats, derived from a cross between Dahl salt-sensitive and Zucker rats, as a new animal model of metabolic syndrome. We have now examined the effects of estrogen replacement on cardiac pathophysiology in ovariectomized female DS/obese (Ovx-DS/obese) rats. Animals subjected to ovariectomy at 7 weeks of age were implanted subcutaneously with a 60-day release pellet containing 0.5 mg of 17 beta-estradiol (E-2) or placebo at 8 weeks. Age-matched female homozygous lean littermates (DahlS.Z-Lepr(+)/Lepr(+) or DS/lean rats) of DS/obese rats served as controls. Animals were maintained on a normal diet and were subjected to echocardiography followed by various pathological analyses at 13 weeks of age. Ovx-DS/obese rats manifested hypertension at 7 weeks of age and thereafter and showed left ventricular (LV) fibrosis and diastolic dysfunction at 13 weeks. Treatment with E-2 attenuated hypertension in Ovx-DS/obese rats but had no effect on blood pressure in ovariectomized female DS/lean (Ovx-DS/lean) rats. E-2 treatment exacerbated LV fibrosis and diastolic dysfunction, as well as further increased cardiac oxidative stress and inflammation in Ovx-DS/obese rats, and it elicited similar effects in Ovx-DS/lean rats. E-2 reduced food intake, body weight, and visceral fat content in both Ovx-DS/obese and Ovx-DS/lean rats. E-2 treatment attenuated hypertension and obesity but exacerbated LV fibrosis and diastolic dysfunction in Ovx-DS/obese rats, with these latter effects being associated with increased cardiac oxidative stress and inflammation. (Hypertension. 2012; 59: 694-704.). Online Data Supplement
C1 [Nakashima, Chieko; Nagata, Kohzo] Nagoya Univ, Sch Hlth Sci, Dept Med Technol, Higashi Ku, Nagoya, Aichi 4618673, Japan.
   [Murase, Tamayo; Hattori, Takuya; Ohtake, Masafumi; Takatsu, Miwa] Nagoya Univ, Grad Sch Med, Dept Pathophysiol, Lab Sci, Nagoya, Aichi 4648601, Japan.
   [Murase, Tamayo] Nagoya Univ, Grad Sch Med, Dept Cardiol, Nagoya, Aichi 4648601, Japan.
C3 Nagoya University; Nagoya University; Nagoya University
RP Nagata, K (corresponding author), Nagoya Univ, Sch Hlth Sci, Dept Med Technol, Higashi Ku, 1-1-20 Daikominami, Nagoya, Aichi 4618673, Japan.
EM nagata@met.nagoya-u.ac.jp
RI Murohara, Toyoaki/M-4958-2014
FU Nippon Boehringer Ingelheim Co Ltd (Tokyo, Japan); Mochida
   Pharmaceutical Co Ltd (Tokyo, Japan); Japanese government
FX This work was supported by unrestricted research grants from Nippon
   Boehringer Ingelheim Co Ltd (Tokyo, Japan) and Mochida Pharmaceutical Co
   Ltd (Tokyo, Japan), as well as by Management Expenses Grants from the
   Japanese government to Nagoya University.
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NR 61
TC 31
Z9 32
U1 0
U2 8
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0194-911X
EI 1524-4563
J9 HYPERTENSION
JI Hypertension
PD MAR
PY 2012
VL 59
IS 3
BP 694
EP U369
DI 10.1161/HYPERTENSIONAHA.111.180976
PG 19
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 911KF
UT WOS:000301715000035
PM 22275535
OA Bronze
DA 2025-06-11
ER

PT J
AU Rubio-Ruiz, ME
   Guarner-Lans, V
   Pérez-Torres, I
   Soto, ME
AF Esther Rubio-Ruiz, Maria
   Guarner-Lans, Veronica
   Perez-Torres, Israel
   Elena Soto, Maria
TI Mechanisms Underlying Metabolic Syndrome-Related Sarcopenia and Possible
   Therapeutic Measures
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE sarcopenia; metabolic syndrome; skeletal muscle; obesity; sarcopenia
   treatment
ID SKELETAL-MUSCLE MASS; GLYCATION END-PRODUCTS; BIOAVAILABLE SERUM
   TESTOSTERONE; OVERLOAD-INDUCED HYPERTROPHY; RENIN-ANGIOTENSIN SYSTEM;
   NECROSIS-FACTOR-ALPHA; DIET-INDUCED OBESITY; INSULIN-RESISTANCE;
   BODY-COMPOSITION; VITAMIN-D
AB Although there are several reviews that report the interrelationship between sarcopenia and obesity and insulin resistance, the relation between sarcopenia and the other signs that compose the metabolic syndrome (MetS) has not been extensively revised. Here, we review the mechanisms underlying MetS-related sarcopenia and discuss the possible therapeutic measures proposed. A vicious cycle between the loss of muscle and the accumulation of intramuscular fat might be associated with MetS via a complex interplay of factors including nutritional intake, physical activity, body fat, oxidative stress, proinflammatory cytokines, insulin resistance, hormonal changes, and mitochondrial dysfunction. The enormous differences in lipid storage capacities between the two genders and elevated amounts of endogenous fat having lipotoxic effects that lead to the loss of muscle mass are discussed. The important repercussions of MetS-related sarcopenia on other illnesses that lead to increased disability, morbidity, and mortality are also addressed. Additional research is needed to better understand the pathophysiology of MetS-related sarcopenia and its consequences. Although there is currently no consensus on the treatment, lifestyle changes including diet and power exercise seem to be the best options.
C1 [Esther Rubio-Ruiz, Maria; Guarner-Lans, Veronica] Inst Nacl Cardiol Ignacio Chavez, Dept Physiol, Juan Badiano 1,Secc 16, Mexico City 14080, DF, Mexico.
   [Perez-Torres, Israel] Inst Nacl Cardiol Ignacio Chavez, Dept Pathol, Juan Badiano 1,Secc 16, Mexico City 14080, DF, Mexico.
   [Elena Soto, Maria] Inst Nacl Cardiol Ignacio Chavez, Dept Immunol, Juan Badiano 1,Secc 16, Mexico City 14080, DF, Mexico.
C3 National Institute of Cardiology - Mexico; National Institute of
   Cardiology - Mexico; National Institute of Cardiology - Mexico
RP Guarner-Lans, V (corresponding author), Inst Nacl Cardiol Ignacio Chavez, Dept Physiol, Juan Badiano 1,Secc 16, Mexico City 14080, DF, Mexico.
EM esther.rubio@cardiologia.org.mx; veronica.guarner@cardiologia.org.mx;
   israel.perez@cardiologia.org.mx; elena.soto@cardiologia.org.mx
RI Pérez Torres, Israel/AAE-2579-2022; Guarner-Lans, Verónica/AFW-3723-2022
OI Guarner-Lans, Veronica/0000-0002-2655-7590; Perez-Torres,
   Israel/0000-0001-6510-2954; Soto, Maria Elena/0000-0003-1332-2888;
   Rubio-Ruiz, Maria Esther/0000-0002-8844-2078
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NR 198
TC 116
Z9 120
U1 0
U2 19
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD FEB 1
PY 2019
VL 20
IS 3
AR 647
DI 10.3390/ijms20030647
PG 23
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Biochemistry & Molecular Biology; Chemistry
GA HQ4WR
UT WOS:000462412500191
PM 30717377
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Lozano, I
   Van der Werf, R
   Bietiger, W
   Seyfritz, E
   Peronet, C
   Pinget, M
   Jeandidier, N
   Maillard, E
   Marchioni, E
   Sigrist, S
   Dal, S
AF Lozano, Iona
   Van der Werf, Remmelt
   Bietiger, William
   Seyfritz, Elodie
   Peronet, Claude
   Pinget, Michel
   Jeandidier, Nathalie
   Maillard, Elisa
   Marchioni, Eric
   Sigrist, Severine
   Dal, Stephanie
TI High-fructose and high-fat diet-induced disorders in rats: impact on
   diabetes risk, hepatic and vascular complications
SO NUTRITION & METABOLISM
LA English
DT Article
DE High-fat high-fructose diet; Metabolic syndrome; Type 2 diabetes;
   Oxidative stress; Hepatic complications; Vascular complications;
   Endothelial dysfunction
ID ENDOTHELIAL DYSFUNCTION; INSULIN-RESISTANCE; OXIDATIVE STRESS;
   LIVER-DISEASE; METABOLIC SYNDROME; FREE-RADICALS;
   CARDIOVASCULAR-DISEASE; LIPID-METABOLISM; OBESITY; CONSUMPTION
AB Background: As a result of the increased consumption of sugar-rich and fatty-products, and the increase in preference for such products, metabolic disorders are becoming more common at a younger age. Fructose is particularly used in prepared foods and carbonated beverages. We investigated the impact of regular consumption of fructose, in combination or not with fatty food, on the onset of metabolic syndrome and type 2 diabetes (T2D). We evaluated the metabolic, oxidative, and functional effects on the liver and blood vessels, both related to diabetes complications.
   Methods: High-fat diet (HFD), high-fructose beverages (HF) or both (HFHF) were compared to rats fed with normal diet (ND) for 8 months to induce T2D and its metabolic, oxidative, and functional complications. Metabolic control was determined by measuring body weight, fasting blood glucose, C-peptide, HOMA2-IR, leptin, and cholesterol; oxidative parameters were studied by lipid peroxidation and total antioxidant capacity in plasma and the use of ROS labelling on tissue. Histological analysis was performed on the liver and endothelial function was performed in main mesenteric artery using organ-baths.
   Results: After 2 months, HFHF and HFD increased body weight, leptin, HOMA2-IR associated to steatosis, oxidative stress in plasma and tissues, whereas HF had only a transient increase of leptin and c-peptide. Only HFHF induced fasting hyperglycaemia after 6 months and persistent hyperinsulinaemia and fasting hyperglycaemia with complicated steatosis (inflammation and fibrosis) after 8 months. HFHF and HFD induced endothelial dysfunction at 8 months of diet.
   Conclusions: Six months, high fat and high carbohydrate induced T2D with widespread tissues effects. We demonstrated the role of oxidative stress in pathogenesis as well as in complications (hepatic and vascular), reinforcing interest in the use of antioxidants in the prevention and treatment of metabolic diseases, including T2D.
C1 [Lozano, Iona; Van der Werf, Remmelt; Bietiger, William; Seyfritz, Elodie; Peronet, Claude; Maillard, Elisa; Sigrist, Severine; Dal, Stephanie] Univ Strasbourg, UMR DIATHEC, Ctr Europeen Etud Diabet, Federat Med Translat Strasbourg,EA 7294, Bld Rene Leriche, F-67200 Strasbourg, France.
   [Van der Werf, Remmelt; Marchioni, Eric] Fac Pharm, UMR 7178, IPHC LC4, Equipe Chim Analyt Mol BioAct, Illkirch Graffenstaden, France.
   [Pinget, Michel; Jeandidier, Nathalie] HUS, Struct Endocrinol Diabet Nutr & Addictol, Pole NUDE, F-67000 Strasbourg, France.
C3 Universites de Strasbourg Etablissements Associes; Universite de
   Strasbourg; Centre National de la Recherche Scientifique (CNRS); CNRS -
   National Institute of Nuclear and Particle Physics (IN2P3); Universites
   de Strasbourg Etablissements Associes; Universite de Strasbourg; CHU
   Strasbourg
RP Sigrist, S (corresponding author), Univ Strasbourg, UMR DIATHEC, Ctr Europeen Etud Diabet, Federat Med Translat Strasbourg,EA 7294, Bld Rene Leriche, F-67200 Strasbourg, France.
EM s.sigrist@ceed-diabete.org
FU CRA (Conseil Regional d'Alsace); foundation "Vaincre le Diabete";
   company ASDIA (Assistance Service Diabete)
FX We are grateful to the CRA (Conseil Regional d'Alsace), the foundation
   "Vaincre le Diabete", and the company ASDIA (Assistance Service Diabete)
   for funding this project. The authors would also like to express their
   gratitude to Pr Valerie Schini-Kerth (UMR 7175 Centre National de la
   Recherche Scientifique, Universite de Strasbourg, Departement de
   Pharmacologie et Physicochimie, Faculte de Pharmacie, Illkirch, France)
   for lending us the isolated-organ chamber.
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NR 62
TC 230
Z9 247
U1 7
U2 140
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1743-7075
J9 NUTR METAB
JI Nutr. Metab.
PD FEB 25
PY 2016
VL 13
AR 15
DI 10.1186/s12986-016-0074-1
PG 13
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA DE9BL
UT WOS:000370930300001
PM 26918024
OA gold, Green Published
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Tapia, E
   Cristóbal, M
   García-Arroyo, FE
   Soto, V
   Monroy-Sánchez, F
   Pacheco, U
   Lanaspa, MA
   Roncal-Jiménez, CA
   Cruz-Robles, D
   Ishimoto, T
   Madero, M
   Johnson, RJ
   Sánchez-Lozada, LG
AF Tapia, Edilia
   Cristobal, Magdalena
   Garcia-Arroyo, Fernando E.
   Soto, Virgilia
   Monroy-Sanchez, Fabiola
   Pacheco, Ursino
   Lanaspa, Miguel A.
   Roncal-Jimenez, Carlos A.
   Cruz-Robles, David
   Ishimoto, Takuji
   Madero, Magdalena
   Johnson, Richard J.
   Sanchez-Lozada, Laura-Gabriela
TI Synergistic effect of uricase blockade plus physiological amounts of
   fructose-glucose on glomerular hypertension and oxidative stress in rats
SO AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
LA English
DT Article
DE uric acid; insulin resistance; glomerular hypertension; liver steatosis
ID SWEETENED BEVERAGE CONSUMPTION; INDUCED METABOLIC SYNDROME; SERUM URATE
   LEVELS; BLOOD-PRESSURE; INSULIN SENSITIVITY; SPRAGUE-DAWLEY;
   POTENTIAL-ROLE; BREEDER RATS; FATTY LIVER; ACID
AB Tapia E, Cristobal M, Garcia-Arroyo FE, Soto V, Monroy-Sanchez F, Pacheco U, Lanaspa MA, Roncal-Jimenez CA, Cruz-Robles D, Ishimoto T, Madero M, Johnson RJ, Sanchez-Lozada LG. Synergistic effect of uricase blockade plus physiological amounts of fructose-glucose on glomerular hypertension and oxidative stress in rats. Am J Physiol Renal Physiol 304: F727-F736, 2013. First published January 9, 2012; doi:10.1152/ajprenal.00485.2012.-Fructose in sweetened beverages (SB) increases the risk for metabolic and cardiorenal disorders, and these effects are in part mediated by a secondary increment in uric acid (UA). Rodents have an active uricase, thus requiring large doses of fructose to increase plasma UA and to induce metabolic syndrome and renal hemodynamic changes. We therefore hypothesized that the effects of fructose in rats might be enhanced in the setting of uricase inhibition. Four groups of male Sprague-Dawley rats (n = 7/group) were studied during 8 wk: water + vehicle (V), water + oxonic acid (OA; 750 mg/k BW), sweetened beverage (SB; 11% fructose-glucose combination) + V, and SB + OA. Systemic blood pressure, plasma UA, triglycerides (TG), glucose and insulin, glomerular hemodynamics, renal structural damage, renal cortex and liver UA, TG, markers of oxidative stress, mitDNA, fructokinase, and fatty liver synthase protein expressions were evaluated at the end of the experiment. Chronic hyperuricemia and SB induced features of the metabolic syndrome, including hypertension, hyperuricemia, hyperglycemia, and systemic and hepatic TG accumulation. OA alone also induced glomerular hypertension, and SB alone induced insulin resistance. SB + OA induced a combined phenotype including metabolic and renal alterations induced by SB or OA alone and in addition also acted synergistically on systemic and glomerular pressure, plasma glucose, hepatic TG, and oxidative stress. These findings explain why high concentrations of fructose are required to induce greater metabolic changes and renal disease in rats whereas humans, who lack uricase, appear to be much more sensitive to the effects of fructose.
C1 [Tapia, Edilia; Cristobal, Magdalena; Garcia-Arroyo, Fernando E.; Monroy-Sanchez, Fabiola; Pacheco, Ursino; Sanchez-Lozada, Laura-Gabriela] Inst Nacl Cardiol Ignacio Chavez, Lab Renal Physiopathol, Mexico City, DF, Mexico.
   [Tapia, Edilia; Cristobal, Magdalena; Garcia-Arroyo, Fernando E.; Monroy-Sanchez, Fabiola; Pacheco, Ursino; Madero, Magdalena; Sanchez-Lozada, Laura-Gabriela] Inst Nacl Cardiol Ignacio Chavez, Dept Nephrol, Mexico City, DF, Mexico.
   [Soto, Virgilia] Inst Nacl Cardiol Ignacio Chavez, Dept Pathol, Mexico City, DF, Mexico.
   [Lanaspa, Miguel A.; Roncal-Jimenez, Carlos A.; Ishimoto, Takuji; Johnson, Richard J.] Univ Colorado, Div Renal Dis & Hypertens, Denver, CO 80202 USA.
   [Cruz-Robles, David] Inst Nacl Cardiol Ignacio Chavez, Dept Mol Biol, Mexico City, DF, Mexico.
C3 National Institute of Cardiology - Mexico; National Institute of
   Cardiology - Mexico; National Institute of Cardiology - Mexico;
   University of Colorado System; University of Colorado Denver; National
   Institute of Cardiology - Mexico
RP Sánchez-Lozada, LG (corresponding author), INC Ignacio Chavez Mexico City, Lab Renal Physiopathol, Juan Badiano 1, Mexico City 14080, DF, Mexico.
EM lgsanchezlozada@gmail.com
RI Sanchez-Lozada, Laura/AAS-2104-2021; Lanaspa, Miguel/AAO-4971-2020;
   Cruz-Robles, David/C-7278-2015; Ishimoto, Takuji/M-4873-2014
OI Tapia, Edilia/0000-0001-7955-816X; Cruz-Robles,
   David/0000-0003-4234-9561; Ishimoto, Takuji/0000-0002-9861-5331;
   Sanchez-Lozada, Laura-Gabriela/0000-0003-0348-9617; Garcia Arroyo,
   Fernando Enrique/0000-0003-1545-9765
FU National Heart, Lung, and Blood Institute [HL-068607-10]; National
   Council of Science and Technology (CONACyT) Mexico [133232, 167949]
FX Funding was supported in part by National Heart, Lung, and Blood
   Institute Grant HL-068607-10 and National Council of Science and
   Technology (CONACyT) Mexico Grants 133232 and No. 167949.
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NR 70
TC 61
Z9 65
U1 1
U2 26
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 1931-857X
EI 1522-1466
J9 AM J PHYSIOL-RENAL
JI Am. J. Physiol.-Renal Physiol.
PD MAR
PY 2013
VL 304
IS 6
BP F727
EP F736
DI 10.1152/ajprenal.00485.2012
PG 10
WC Physiology; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology; Urology & Nephrology
GA 107EG
UT WOS:000316197000011
PM 23303409
OA Green Published
DA 2025-06-11
ER

PT J
AU Alroy, S
   Preis, M
   Barzilai, M
   Cassel, A
   Lavie, L
   Halon, DA
   Amir, O
   Lewis, BS
   Flugelman, MY
AF Alroy, Sharon
   Preis, Meir
   Barzilai, Menashe
   Cassel, Aliza
   Lavie, Lena
   Halon, David A.
   Amir, Ofer
   Lewis, Basil S.
   Flugelman, Moshe Y.
TI Endothelial cell dysfunction in women with cardiac syndrome X and
   MTHFR C677T mutation
SO ISRAEL MEDICAL ASSOCIATION JOURNAL
LA English
DT Article
DE syndrome X; MTHFR; homocysteine
ID NORMAL CORONARY-ARTERIES; METHYLENETETRAHYDROFOLATE REDUCTASE;
   ANGINA-PECTORIS; FOLIC-ACID; VASCULAR-DISEASE; COMMON MUTATION; RISK
   FACTOR; CHEST PAIN; HOMOCYSTEINE; HYPERHOMOCYSTEINEMIA
AB Background: The etiology of chest pain with normal epicardial coronary arteries (cardiac syndrome X) seems to be related to endothelial cell dysfunction. Multiple factors are implicated in the pathophysiology, including elevated levels of homocysteine in the blood. Mutations in the MTHFR gene are associated with elevated levels of homocysteine.
   Objectives: To test whether abnormal homocysteine metabolism is associated with syndrome X.
   Methods: Forty-two women with chest pain, positive stress test and normal coronary arteries (syndrome X) and 100 asymptomatic women (controls) were studied for the C677T mutation. Vitamin 1312, folic acid, and plasma levels of homocysteine were also measured. Endothelial cell function was studied in 10 patients with syndrome X and homozygosity for C677T mutation, and in 10 matched healthy controls. Folic acid (5 mg daily) was prescribed to syndrome X patients after initial measurements of ECF. Following 13 weeks of treatment, ECF and blood tests were repeated and compared to baseline measurements.
   Results: Homozygosity for C677T mutation was doubled in syndrome X vs. control (33%, 14/42 vs. 16%, 16/100, P < 0.02), and homocysteine levels were increased (9.16 +/- 2.4 vs. 8.06 +/- 2.6 mu mol/L, P= 0.02). In the 10 homozygous patients, homocysteine levels decreased significantly after treatment with 5 mg/day folic acid (10 +/- 3.3 vs. 5.4 +/- 1.1 mu mol/L, P= 0.004). Abnormal baseline ECF improved after treatment with folic acid: flow-mediated dilatation was greater (11.3 +/- 7.9% vs. 0.7 +/- 4.5%, P < 0.002), as was nitroglycerin mediated dilatation (15.2 +/- 9.0% vs. 5.6 +/- 6.4%, P < 0.003). Frequency of chest pain episodes was significantly reduced after 13 weeks of folic acid treatment.
   Conclusion: Our findings establish the association between the C677T mutation, endothelial cell dysfunction and cardiac syndrome X, and provide a novel and simple therapy for a subset of patients with syndrome X and homozygosity for the C677T mutation.
C1 Lady Davies Carmel Med Ctr, Dept Cardiovasc Med, IL-34632 Haifa, Israel.
   Lady Davies Carmel Med Ctr, Dept Radiol, IL-34632 Haifa, Israel.
   Lady Davies Carmel Med Ctr, Dept Mol Hematol, IL-34632 Haifa, Israel.
   Technion Israel Inst Technol, Rappaport Fac Med, Dept Cell Biol, Haifa, Israel.
C3 Clalit Health Services; Carmel Medical Center; Clalit Health Services;
   Carmel Medical Center; Clalit Health Services; Carmel Medical Center;
   Technion Israel Institute of Technology; Rappaport Faculty of Medicine
RP Flugelman, MY (corresponding author), Lady Davies Carmel Med Ctr, Dept Cardiovasc Med, IL-34632 Haifa, Israel.
EM preis_m@netvision.net.il; myf@tx.technion.ac.il
RI Lavandero, Sergio/B-6001-2013; Preis, Meir/ABH-7606-2020
OI Halon, David/0000-0003-1865-7919
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NR 25
TC 13
Z9 14
U1 0
U2 3
PU ISRAEL MEDICAL ASSOC JOURNAL
PI RAMAT GAN
PA 2 TWIN TOWERS, 11TH FL, 35 JABOTINSKY ST, PO BOX 3604, RAMAT GAN 52136,
   ISRAEL
SN 1565-1088
J9 ISR MED ASSOC J
JI Isr. Med. Assoc. J.
PD APR
PY 2007
VL 9
IS 4
BP 321
EP 325
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 162YH
UT WOS:000246124900022
PM 17491230
DA 2025-06-11
ER

PT J
AU Mahdavi, A
   Mohammadi, H
   Foshati, S
   Shokri-Mashhadi, N
   Clark, CCT
   Moafi, A
   Rouhani, MH
AF Mahdavi, Atena
   Mohammadi, Hamed
   Foshati, Sahar
   Shokri-Mashhadi, Nafiseh
   Clark, Cain C. T.
   Moafi, Alireza
   Rouhani, Mohammad Hossein
TI Effects of the dietary approach to stop hypertension (DASH) diet on
   blood pressure, blood glucose, and lipid profile in adolescents with
   hemophilia: A randomized clinical trial
SO FOOD SCIENCE & NUTRITION
LA English
DT Article
DE adolescents; blood glucose; blood pressure; dietary approach to stop
   hypertension; hemophilia; lipid profile
ID CHILDHOOD METABOLIC SYNDROME; CARDIOVASCULAR RISK; METAANALYSIS;
   COMORBIDITIES; CHILDREN; OBESITY; STRESS; SODIUM; FOLLOW
AB Children with hemophilia are an enhanced risk of modifiable cardiovascular and metabolic abnormalities. There is currently no nutritional guideline to prevent or manage cardiometabolic risk factors in these patients. Therefore, the present study sought to investigate the effect of the Dietary Approaches to Stop Hypertension (DASH) diet on cardiovascular and metabolic risk factors among children with hemophilia. In this parallel randomized clinical trial, 40 children (all male) with hemophilia were randomly allocated to the DASH group (n = 20) or control group (n = 20) for 10 weeks. The intervention group received the DASH diet (50%-55% of energy from carbohydrate, 27%-30% of energy from fat and 16%-18% energy from protein), and the control group received nutritional recommendations based on healthy eating practices. Systolic blood pressure (SBP), diastolic blood pressure (DBP), fasting blood sugar (FBS), triglyceride (TG), total cholesterol (TC), low-density lipoprotein (LDL), and high-density lipoprotein (HDL) were measured at the beginning and end of the study. Serum vitamin C was measured as a biomarker of compliance with the DASH diet. Study was registered at IRCT.ir (IRCT20130903014551N6). A significant increase in serum vitamin C in the DASH diet group was observed compared to the control group (p = .001), indicating good compliance with the DASH diet. There was a significant reduction in SBP (-0.48 mmHg), DBP (-0.48 mmHg), FBS (-5.86 mg/dl), TC (-16.07 mg/dl), TG (-17.21 mg/dl), and LDL-C (-9.79 mg/dl), and a significant increase in HDL-C (3.39 mg/dl), in the DASH diet group compared with the control group. Adherence to the DASH diet in children with hemophilia yielded beneficial effects in blood pressure, lipid profiles, and FBS.
C1 [Mahdavi, Atena; Mohammadi, Hamed; Foshati, Sahar; Shokri-Mashhadi, Nafiseh; Rouhani, Mohammad Hossein] Isfahan Univ Med Sci, Sch Nutr & Food Sci, Food Secur Res Ctr, Esfahan, Iran.
   [Mahdavi, Atena; Rouhani, Mohammad Hossein] Isfahan Univ Med Sci, Sch Nutr & Food Sci, Dept Community Nutr, Esfahan, Iran.
   [Mohammadi, Hamed; Foshati, Sahar; Shokri-Mashhadi, Nafiseh] Isfahan Univ Med Sci, Dept Clin Nutr, Sch Nutr & Food Sci, Esfahan, Iran.
   [Clark, Cain C. T.] Coventry Univ, Ctr Intelligent Healthcare, Coventry, W Midlands, England.
   [Moafi, Alireza] Isfahan Univ Med Sci, Pediat Hematol & Oncol, Esfahan, Iran.
C3 Isfahan University of Medical Sciences; Isfahan University of Medical
   Sciences; Isfahan University of Medical Sciences; Coventry University;
   Isfahan University of Medical Sciences
RP Rouhani, MH (corresponding author), Isfahan Univ Med Sci, Sch Nutr & Food Sci, Dept Community Nutr, Esfahan, Iran.
EM sm_rouhani@nutr.mui.ac.ir
RI Rouhani, Mohammad/H-6937-2019; Foshati, Sahar/AAR-2447-2020; Mohammadi,
   Hamed/Q-3166-2019; Clark, Cain/I-4480-2019; shokri-Mashhadi,
   nafiseh/AAU-5129-2020
OI Foshati, Sahar/0000-0002-2669-670X; Rouhani, Mohammad
   Hossein/0000-0003-2451-0083; Clark, Dr. Cain/0000-0002-6610-4617
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Z9 10
U1 0
U2 16
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2048-7177
J9 FOOD SCI NUTR
JI Food Sci. Nutr.
PD JAN
PY 2021
VL 9
IS 1
BP 145
EP 153
DI 10.1002/fsn3.1972
EA OCT 2020
PG 9
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA PS2AE
UT WOS:000585927200001
PM 33473278
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Vranian, MN
   Keenan, T
   Blaha, MJ
   Silverman, MG
   Michos, ED
   Minder, CM
   Blumenthal, RS
   Nasir, K
   Meneghelo, RS
   Santos, RD
AF Vranian, Michael N.
   Keenan, Tanya
   Blaha, Michael J.
   Silverman, Michael G.
   Michos, Erin D.
   Minder, C. Michael
   Blumenthal, Roger S.
   Nasir, Khurram
   Meneghelo, Romeu S.
   Santos, Raul D.
TI Impact of Fitness Versus Obesity on Routinely Measured Cardiometabolic
   Risk in Young, Healthy Adults
SO AMERICAN JOURNAL OF CARDIOLOGY
LA English
DT Article
ID CARDIOVASCULAR-DISEASE MORTALITY; CARDIORESPIRATORY FITNESS;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; AEROBIC FITNESS; FATNESS; MEN;
   PREDICTORS; ASSOCIATIONS
AB Obesity demonstrates a direct relation with cardiovascular risk and all-cause mortality, while cardiorespiratory fitness demonstrates an inverse relation. In clinical practice, several cardiometabolic (CM) risk factors are commonly measured to gauge cardiovascular risk, but the interaction between fitness and obesity with regard to CM risk has not been fully explored. In this study, 2,634 Brazilian adults referred for employer-sponsored heath exams were assessed. Obesity was defined as body mass index >30 kg/m(2) or waist circumference >102 cm in men or >88 cm in women when body mass index was 25 to 30 kg/m(2). Fitness was quantified by stage achieved on an Ellestad treadmill stress test, with those completing stage 4 considered fit. Hepatic steatosis was determined by ultrasound. CM risk factors were compared after stratifying patients into 4 groups: fit and normal weight, fit and obese, unfit and normal weight, and unfit and obese. Approximately 22% of patients were obese; 12% were unfit. Fitness and obesity were moderately correlated (rho = 0.38 to 0.50). The sample included 6.5% unfit and normal-weight subjects and 16% fit and obese subjects. In overweight and obese patients, fitness was negatively associated with CM risk (p < 0.01 for all values). In fit patients, increasing body mass index was positively associated with CM risk (p < 0.01 for all values). In instances of discordance between fitness and obesity, obesity was the stronger determinant of CM risk. In conclusion, fitness and obesity are independently associated with CM risk. The effects of fitness and obesity are additive, but obesity is more strongly associated with CM risk when fitness and obesity are discordant. These findings underscore the need for weight loss in obese patients and suggest an unmeasured benefit of fitness. (C) 2013 Elsevier Inc. All rights reserved. (Am J Cardiol 2013;111:991-995)
C1 [Vranian, Michael N.; Blaha, Michael J.; Silverman, Michael G.; Michos, Erin D.; Minder, C. Michael; Blumenthal, Roger S.; Nasir, Khurram] Johns Hopkins Ciccarone Ctr Prevent Heart Dis, Baltimore, MD USA.
   [Keenan, Tanya] Univ Penn, Perelman Sch Med, Philadelphia, PA 19104 USA.
   [Nasir, Khurram] Baptist Hlth South Florida, Miami, FL USA.
   [Meneghelo, Romeu S.; Santos, Raul D.] Hosp Israelita Albert Einstein, Prevent Med Ctr, Sao Paulo, Brazil.
   [Santos, Raul D.] Univ Sao Paulo, Med Sch Hosp, Inst Heart, Lipid Clin, Sao Paulo, Brazil.
C3 Johns Hopkins University; Johns Hopkins Medicine; University of
   Pennsylvania; Hospital Israelita Albert Einstein; Universidade de Sao
   Paulo
RP Santos, RD (corresponding author), Hosp Israelita Albert Einstein, Prevent Med Ctr, Sao Paulo, Brazil.
EM raul.santos@incor.usp.br
RI Nasir, Khurram/A-2317-2008; Santos, Raul/A-1170-2010; Blumenthal,
   Roger/H-3223-2018
OI Michos, Erin/0000-0002-5547-5084; Keenan, Tanya/0000-0001-5300-9998
CR [Anonymous], RADIOL RES PRACT
   [Anonymous], ACSMS MET CALC HDB
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NR 25
TC 9
Z9 11
U1 0
U2 11
PU EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
PI BRIDGEWATER
PA 685 ROUTE 202-206 STE 3, BRIDGEWATER, NJ 08807 USA
SN 0002-9149
EI 1879-1913
J9 AM J CARDIOL
JI Am. J. Cardiol.
PD APR 1
PY 2013
VL 111
IS 7
BP 991
EP 995
DI 10.1016/j.amjcard.2012.12.022
PG 5
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 117AE
UT WOS:000316923700012
PM 23340029
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Todosenko, N
   Yurova, K
   Vulf, M
   Khaziakhmatova, O
   Malashchenko, V
   Khlusov, I
   Komar, A
   Kozlov, I
   Litvinova, L
AF Todosenko, Natalia
   Yurova, Kristina
   Vulf, Maria
   Khaziakhmatova, Olga
   Malashchenko, Vladimir
   Khlusov, Igor
   Komar, Alexandra
   Kozlov, Ivan
   Litvinova, Larisa
TI The Role of MicroRNAs in Mitochondrial Homeostasis and their Involvement
   in the Pathogenesis of Obesity and Metabolic Syndrome: A Focus on
   MicroRNAs
SO CURRENT MEDICINAL CHEMISTRY
LA English
DT Review; Early Access
DE Mitochondria; metabolic syndrome; obesity; microRNAs; mitomicroRNAs;
   cell cultures
ID ADIPOSE-TISSUE INFLAMMATION; HEPATIC INSULIN-RESISTANCE; OXIDATIVE
   STRESS; SKELETAL-MUSCLE; DOWN-REGULATION; UP-REGULATION; MITO-PORTER;
   ISCHEMIA/REPERFUSION INJURY; LIPID-PEROXIDATION; ENERGY-METABOLISM
AB The maintenance of the functional potential of mitochondria is directly related to epigenetic factors, microRNAs (miRs), and mitomicroRNAs (mitomiRs). An important role in the development of metabolic syndrome (MetS)/obesity is attributed to miRs, which have pro-inflammatory or anti-inflammatory potential and can penetrate the mitochondrial matrix. Deciphering the mechanisms responsible for the transport of miRs into the mitochondria would, we believe, allow us to use the knowledge obtained to build designs for the transport of drugs/mitomiRs into cells/mitochondria with low toxicity. A thorough understanding of the polyfunctionality/versatility of individual mitomiRs in specific cells (cell cultures, tissues: adipocytes, brain cells) will allow targeting cellular metabolism to comprehensively block the central link in disease pathogenesis with low potential side effects of this treatment. In this review, we have attempted to identify the key miRs/mitomiRs associated with MetS that affect mitochondrial function. In our opinion, further research should focus specifically on the miR/mitomiRs described here and further investigate their potential in the development of MetS and its components.
C1 [Todosenko, Natalia; Yurova, Kristina; Vulf, Maria; Khaziakhmatova, Olga; Malashchenko, Vladimir; Khlusov, Igor; Komar, Alexandra; Litvinova, Larisa] Immanuel Kant Balt Fed Univ, Ctr Immunol & Cellular Biotechnol, Kaliningrad 236001, Russia.
   [Khlusov, Igor; Litvinova, Larisa] Siberian State Med Univ, Lab Cellular & Microfluid Technol, Tomsk 634050, Russia.
   [Kozlov, Ivan] IM Sechenov First Moscow State Med Univ, Inst Profess Educ, Moscow, Russia.
C3 Immanuel Kant Baltic Federal University; Siberian State Medical
   University; Sechenov First Moscow State Medical University
RP Litvinova, L (corresponding author), Immanuel Kant Balt Fed Univ, Ctr Immunol & Cellular Biotechnol, Kaliningrad 236001, Russia.
EM larisalitvinova@yandex.ru
RI Yurova, Kristina/F-7614-2017; Vulf, Maria/E-4926-2017; Malashchenko,
   Vladimir/F-8974-2017; Litvinova, Larisa/A-9672-2014; Todosenko,
   Natalia/P-6176-2017; Khaziakhmatova, Olga/F-7767-2017
FU Russian Science Foundation [23-15-00061]
FX This research was funded by Russian Science Foundation (project no.
   23-15-00061).
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NR 354
TC 0
Z9 0
U1 0
U2 0
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 0929-8673
EI 1875-533X
J9 CURR MED CHEM
JI Curr. Med. Chem.
PD 2025 MAR 7
PY 2025
DI 10.2174/0109298673361354250224060829
EA MAR 2025
PG 32
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Pharmacology &
   Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
GA 2DR5P
UT WOS:001480187300001
PM 40059425
DA 2025-06-11
ER

PT J
AU Finicelli, M
   Squillaro, T
   Di Cristo, F
   Di Salle, A
   Melone, MAB
   Galderisi, U
   Peluso, G
AF Finicelli, Mauro
   Squillaro, Tiziana
   Di Cristo, Francesca
   Di Salle, Anna
   Melone, Mariarosa Anna Beatrice
   Galderisi, Umberto
   Peluso, Gianfranco
TI Metabolic syndrome, Mediterranean diet, and polyphenols: Evidence and
   perspectives
SO JOURNAL OF CELLULAR PHYSIOLOGY
LA English
DT Review
DE Mediterranean diet; metabolic syndrome; olive oil; polyphenols;
   resveratrol
ID VIRGIN OLIVE OIL; OXIDATIVE STRESS; INSULIN-RESISTANCE; ADIPOSE-TISSUE;
   CHLOROGENIC ACID; FATTY-ACIDS; ENDOTHELIAL DYSFUNCTION;
   MITOCHONDRIAL-FUNCTION; MYOCARDIAL-INFARCTION; POSSIBLE INVOLVEMENT
AB Metabolic syndrome (MetS) is defined as the co-occurrence of metabolic risk factors that includes insulin resistance, hyperinsulinemia, impaired glucose tolerance, type 2 diabetes mellitus, dyslipidemia, and visceral obesity. The clinical significance of MetS consists of identifying a subgroup of patients sharing a common physiopathological state predisposing to chronic diseases. Clinical and scientific studies pinpoint lifestyle modification as an effective strategy aiming to reduce several features accountable for the risk of MetS onset. Among the healthy dietary patterns, the Mediterranean diet (MedDiet) emerges in terms of beneficial properties associated with longevity. Current evidence highlights the protective effect exerted by MedDiet on the different components of MetS. Interestingly, the effect exerted by polyphenols contained within the representative MedDiet components (i.e., olive oil, red wine, and nuts) seems to be accountable for the beneficial properties associated to this dietary pattern. In this review, we aim to summarize the principal evidence regarding the effectiveness of MedDiet-polyphenols in preventing or delaying the physiopathological components accountable for MetS onset. These findings may provide useful insights concerning the health properties of MedDiet-polyphenols as well as the novel targets destined to a tailored approach to MetS.
C1 [Finicelli, Mauro; Di Salle, Anna; Peluso, Gianfranco] CNR, Inst Agrienvironm Biol & Forestry IBAF, Via P Castellino 111, I-80131 Naples, Italy.
   [Squillaro, Tiziana; Melone, Mariarosa Anna Beatrice] Univ Campania Luigi Vanvitelli, Dept Med Surg Neurol Metab Sci & Aging, Div Neurol 2, Ctr Rare Dis, Naples, Italy.
   [Squillaro, Tiziana; Melone, Mariarosa Anna Beatrice] Univ Campania Luigi Vanvitelli, InterUniv Ctr Res Neurosci, Naples, Italy.
   [Di Cristo, Francesca] Elleva Pharma Srl, Via S Fancesco dAssisi, Naples, Italy.
   [Galderisi, Umberto] Univ Campania Luigi Vanvitelli, Dept Expt Med, Biotechnol & Mol Biol Sect, Naples, Italy.
   [Melone, Mariarosa Anna Beatrice; Galderisi, Umberto] Temple Univ, Dept Biol, Coll Sci & Technol, Sbarro Inst Canc Res & Mol Med,Ctr Biotechnol, Philadelphia, PA 19122 USA.
C3 Consiglio Nazionale delle Ricerche (CNR); Universita della Campania
   Vanvitelli; Universita della Campania Vanvitelli; Universita della
   Campania Vanvitelli; Pennsylvania Commonwealth System of Higher
   Education (PCSHE); Temple University
RP Peluso, G (corresponding author), CNR, Inst Agrienvironm Biol & Forestry IBAF, Via P Castellino 111, I-80131 Naples, Italy.
EM gianfranco.peluso@ibaf.cnr.it
RI Di Cristo, Francesca/AEN-6072-2022; Di Salle, A/AAF-5416-2019;
   Finicelli, Mauro/ABC-1392-2020; Melone, Mariarosa AB/N-6788-2015
OI Melone, Mariarosa AB/0000-0002-7213-9277; Di Salle,
   Anna/0000-0001-6763-3636; Di Cristo, Francesca/0000-0002-4544-6837;
   Finicelli, Mauro/0000-0003-2289-0916
FU PO FESR 2014-2020 - Regione Campania, Asse 1 - obiettivo specifico 1.2,
   Progetto "Sviluppo di nanotecnologie Orientate alla Rigenerazione e
   Ricostruzione tissutale, Implantologia e Sensoristica in Odontoiatria"
   oculistica (SORRISO)" [pdt1-000410]; Project " Studio di fattibilita per
   la progettazione di sistemi di rilascio nanoparticellari a base di
   idrossidi doppi lamellari (layered double hyroxide-LDH) in grado di
   veicolare, in modo controllato e prolungato nel tempo, molecole
   biologicamente attive [N. 0000836/2018]; PON IAMP;C 2014-2020 FESR
   progetto "Micro/nanoformulati innovativi per la valorizzazione di
   molecole bioattive, utili per la salute e il benessere delle
   popolazione, ottenute da prodotti di scarto della filiera ittica
   (FORTUNA)" [F/050347/03IX32]
FX PO FESR 2014-2020 - Regione Campania, Asse 1 - obiettivo specifico 1.2,
   Progetto "Sviluppo di nanotecnologie Orientate alla Rigenerazione e
   Ricostruzione tissutale, Implantologia e Sensoristica in Odontoiatria"
   oculistica (SORRISO)", Grant/Award Number: pdt1-000410; Project " Studio
   di fattibilita per la progettazione di sistemi di rilascio
   nanoparticellari a base di idrossidi doppi lamellari (layered double
   hyroxide-LDH) in grado di veicolare, in modo controllato e prolungato
   nel tempo, molecole biologicamente attive tipo Ca e/o F", Grant/Award
   Number: Prot. N. 0000836/2018; PON I&C 2014-2020 FESR progetto
   "Micro/nanoformulati innovativi per la valorizzazione di molecole
   bioattive, utili per la salute e il benessere delle popolazione,
   ottenute da prodotti di scarto della filiera ittica (FORTUNA)",
   Grant/Award Number: F/050347/03IX32
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NR 149
TC 136
Z9 142
U1 1
U2 128
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0021-9541
EI 1097-4652
J9 J CELL PHYSIOL
JI J. Cell. Physiol.
PD MAY
PY 2019
VL 234
IS 5
BP 5807
EP 5826
DI 10.1002/jcp.27506
PG 20
WC Cell Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Physiology
GA HK7AQ
UT WOS:000458138600041
PM 30317573
DA 2025-06-11
ER

PT J
AU Rayssiguier, Y
   Gueux, E
   Nowacki, W
   Rock, E
   Mazur, A
AF Rayssiguier, Y.
   Gueux, E.
   Nowacki, W.
   Rock, E.
   Mazur, A.
TI High fructose consumption combined with low dietary magnesium intake may
   increase the incidence of the metabolic syndrome by inducing
   inflammation
SO MAGNESIUM RESEARCH
LA English
DT Article
DE magnesium; fructose; metabolic syndrome; inflammation
ID VASCULAR SMOOTH-MUSCLE; C-REACTIVE PROTEIN; HIGH-SUCROSE DIET;
   INSULIN-RESISTANCE; LIPID-PEROXIDATION; GENE-EXPRESSION; DEFICIENT RATS;
   MG-DEFICIENCY; SUBSTANCE-P; ACTIVATION
AB The metabolic syndrome is a cluster of common pathologies: abdominal obesity linked to an excess of visceral fat, insulin resistance, dyslipidemia and hypertension. This syndrome is occurring at epidemic rates, with dramatic consequences for human health worldwide, and appears to have emerged largely from changes in our diet and reduced physical activity. An important but not well-appreciated dietary change has been the substantial increase in fructose intake, which appears to be an important causative factor in the metabolic syndrome. There is also experimental and clinical evidence that the amount of magnesium in the western diet is insufficient to meet individual needs and that magnesium deficiency may contribute to insulin resistance. In recent years, several studies have been published that implicate subclinical chronic inflammation as an important pathogenic factor in the development of metabolic syndrome. Pro-inflammatory molecules produced by adipose tissue have been implicated in the development of insulin resistance. The present review will discuss experimental evidence showing that the metabolic syndrome, high fructose intake and low magnesium diet may all be linked to the inflammatory response. In many ways, fructose-fed rats display the changes observed in the metabolic syndrome and recent studies indicate that high-fructose feeding is associated with NADPH oxidase and renin-angiotensin activation. The production of reactive oxygen species results in the initiation and development of insulin resistance, hyperlipemia and high blood pressure in this model. In this rat model, a few days of experimental magnesium deficiency produces a clinical inflammatory syndrome characterized by leukocyte and macrophage activation, release of inflammatory cytokines, appearance of the acute phase proteins and excessive production of free radicals. Because magnesium acts as a natural calcium antagonist, the molecular basis for the inflammatory response is probably the result of a modulation of the intracellular calcium concentration. Potential mechanisms include the priming of phagocytic cells, the opening of calcium channels, activation of N-methyl-D-aspartate (NMDA) receptors, the activation of nuclear factor-kappaB (NFkB) and activation of the renin-angiotensin system. Since magnesium deficiency has a pro-inflammatory effect, the expected consequence would be an increased risk of developing insulin resistance when magnesium deficiency is combined with a high-fructose diet. Accordingly, magnesium deficiency combined with a high-fructose diet induces insulin resistance, hypertension, dyslipidemia, endothelial activation and prothrombic changes in combination with the upregulation of markers of inflammation and oxidative stress.
C1 INRA, Unite Nutr Humaine, F-63122 St Genes Champanelle, France.
   Fac Vet, PL-50375 Wroclaw, Poland.
C3 INRAE
RP Rayssiguier, Y (corresponding author), INRA, Unite Nutr Humaine, F-63122 St Genes Champanelle, France.
EM yrayssig@clermont.mra.fr
RI Mazur, Andre/AAG-9751-2020
OI Mazur, Andre/0000-0002-1067-5066; Nowacki, Wojciech/0000-0002-8304-0686
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NR 66
TC 87
Z9 100
U1 0
U2 13
PU JOHN LIBBEY EUROTEXT LTD
PI MONTROUGE
PA 127 AVE DE LA REPUBLIQUE, 92120 MONTROUGE, FRANCE
SN 0953-1424
EI 1952-4021
J9 MAGNESIUM RES
JI Magnes. Res.
PD DEC
PY 2006
VL 19
IS 4
BP 237
EP 243
PG 7
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 139HI
UT WOS:000244422500002
PM 17402291
DA 2025-06-11
ER

PT J
AU Ma, WQ
   Sun, XJ
   Zhu, Y
   Liu, NF
AF Ma, Wen-Qi
   Sun, Xue-Jiao
   Zhu, Yi
   Liu, Nai-Feng
TI Metformin attenuates hyperlipidaemia-associated vascular calcification
   through anti-ferroptotic effects
SO FREE RADICAL BIOLOGY AND MEDICINE
LA English
DT Article
DE Metformin; Vascular calcification; Ferroptosis; Periostin; p53
ID SMOOTH-MUSCLE-CELLS; TUMOR-SUPPRESSOR; PERIOSTIN; P53; MECHANISMS;
   ATHEROSCLEROSIS; DIFFERENTIATION; INFLAMMATION; INHIBITION; EXPRESSION
AB Ferroptosis is a form of regulated cell death that involves metabolic dysfunction resulting from iron-dependent excessive lipid peroxidation. Elevated plasma levels of free fatty acids are tightly associated with cardiometabolic risk factors in patients with obesity, diabetes mellitus, and metabolic syndrome. Metformin (Met) is an antidiabetic drug with beneficial cardiovascular disease effects. The aim of this study was to determine the effects of Met on ferroptosis induced by lipid overload and the effects of these changes on vascular smooth muscle cells (VSMCs) calcification. We developed a hyperlipidaemia-related vascular calcification in vivo model with rats fed a high-fat diet combined with vitamin D3 plus nicotine, and palmitic acid (PA), the most abundant long-chain saturated fatty acid in plasma, was used to induce lipid overload and develop an oxidative stress-related calcification model in vitro. The results showed that Met inhibits hyperlipidaemia-associated calcium deposition in the rat aortic tissue. In vitro, treatment of VSMCs with PA stimulates ferroptosis concomitant with increased calcium deposition in VSMCs, while pretreatment with Met attenuates these effects. Furthermore, PA also promotes the protein expression of the extracellular matrix protein periostin (POSTN) and its secretion into the extracellular environment. More importantly, upregulation of POSTN increased the sensitivity of cells to ferroptosis. Mechanistically, upregulation of POSTN suppresses SLC7A11 expression through the inhibition of p53 in VSMCs, which contributes to a decrease in glutathione synthesis and therefore triggers ferroptosis. Interestingly, over expression of p53 attenuates the inhibitory effect of POSTN on SLC7A11 expression, accompanied by increased Gpx4 expression. Furthermore, p53 knockdown suppresses Met-mediated anti-ferroptosis effects in PA-treated VSMCs, which may be related to the downregulation of SLC7A11 expression. In addition, supplementation of VSMCs with Met enhances the antioxidative capacity of VSMCs through Nrf2 signalling activation. Collectively, targeting POSTN in VSMCs may provide a new strategy for vascular calcification prevention or treatment.
C1 [Ma, Wen-Qi; Sun, Xue-Jiao; Zhu, Yi; Liu, Nai-Feng] Southeast Univ 87 Dingjiaqiao, Zhongda Hosp, Sch Med, Dept Cardiol, Nanjing 210009, Peoples R China.
C3 Southeast University - China
RP Liu, NF (corresponding author), Southeast Univ 87 Dingjiaqiao, Zhongda Hosp, Sch Med, Dept Cardiol, Nanjing 210009, Peoples R China.
EM liunf@seu.edu.cn
RI Liu, Nai-feng/AAM-7836-2020
OI Ma, Wen-Qi/0000-0002-0287-8496
FU National Natural Science Foundation of China [81970381]; Fundamental
   Research Funds for the Central Universities; Postgraduate Research &
   Practice Innovation Program of Jiangsu Province [KYCX20_0148,
   KYCX18_0170]
FX This work was supported by National Natural Science Foundation of China
   (81970381) , the Fundamental Research Funds for the Central
   Universities, and the Postgraduate Research & Practice Innovation
   Program of Jiangsu Province (KYCX20_0148, KYCX18_0170) .
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NR 60
TC 112
Z9 121
U1 2
U2 82
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0891-5849
EI 1873-4596
J9 FREE RADICAL BIO MED
JI Free Radic. Biol. Med.
PD MAR
PY 2021
VL 165
BP 229
EP 242
DI 10.1016/j.freeradbiomed.2021.01.033
EA FEB 2021
PG 14
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA RB2YT
UT WOS:000631981900003
PM 33513420
DA 2025-06-11
ER

PT J
AU Lin, Z
   Gonçalves, CMV
   Dai, L
   Lu, HM
   Huang, JH
   Ji, HC
   Wang, DS
   Yi, LZ
   Liang, YZ
AF Lin, Zhang
   Vicente Goncalves, Carlos M.
   Dai, Ling
   Lu, Hong-mei
   Huang, Jian-hua
   Ji, Hongchao
   Wang, Dong-sheng
   Yi, Lun-zhao
   Liang, Yi-zeng
TI Exploring metabolic syndrome serum profiling based on gas chromatography
   mass spectrometry and random forest models
SO ANALYTICA CHIMICA ACTA
LA English
DT Article
DE Metabolic syndrome; Serum profiling; GC-MS; Random forest; Biomarker
ID C-REACTIVE PROTEIN; BLOOD-PRESSURE; IDENTIFICATION; MYOINOSITOL;
   COMPONENTS; RESISTANCE; LIPOLYSIS; SELECTION; OBESITY; STRESS
AB Metabolic syndrome (MetS) is a constellation of the most dangerous heart attack risk factors: diabetes and raised fasting plasma glucose, abdominal obesity, high cholesterol and high blood pressure. Analysis and representation of the variances of metabolic profiles is urgently needed for early diagnosis and treatment of MetS. In current study, we proposed a metabolomics approach for analyzing MetS based on GC-MS profiling and random forest models. The serum samples from healthy controls and MetS patients were characterized by GC-MS. Then, random forest (RF) models were used to visually discriminate the serum changes in MetS based on these GC-MS profiles. Simultaneously, some informative metabolites or potential biomarkers were successfully discovered by means of variable importance ranking in random forest models. The metabolites such as 2-hydroxybutyric acid, inositol and D-glucose, were defined as potential biomarkers to diagnose the MetS. These results obtained by proposed method showed that the combining GC-MS profiling with random forest models was a useful approach to analyze metabolites variances and further screen the potential biomarkers for MetS diagnosis. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Lin, Zhang; Vicente Goncalves, Carlos M.; Dai, Ling; Lu, Hong-mei; Huang, Jian-hua; Ji, Hongchao; Yi, Lun-zhao; Liang, Yi-zeng] Cent South Univ, Coll Chem & Chem Engn, Changsha 410083, Hunan, Peoples R China.
   [Vicente Goncalves, Carlos M.] Univ Cadiz, Fac Ciencias, Dept Quim Analit, Cadiz, Spain.
   [Wang, Dong-sheng] Cent South Univ, Xiangya Hosp, Changsha 410008, Hunan, Peoples R China.
C3 Central South University; Universidad de Cadiz; Central South University
RP Huang, JH (corresponding author), Cent South Univ, Res Ctr Modernizat Tradit Chinese Med Chem & Chem, Changsha 410083, Hunan, Peoples R China.
EM hongmeilu@csu.edu.cn; huangjh85@gmail.com
RI yi, lunzhao/AAS-3256-2021; DAI, LING/KXR-4417-2024; Gonçalves,
   Carlos/N-1816-2015; Huang, Jianhua/C-3929-2011; Ji, Hongchao/I-3676-2019
OI Ji, Hongchao/0000-0002-7364-0741; Liang, Yizeng/0000-0001-8692-3030
FU National Nature Foundation Committee of PR China [21175157, 21105129,
   21375151]; China Hunan Provincial Science and Technology Department
   [2012FJ4139]; Central South University for Special Support of the Basic
   Scientific Research Project [2010QZZD007]; China Postdoctoral Science
   Foundation [201104511]
FX This work is financially supported by the National Nature Foundation
   Committee of PR China (No. 21175157, No. 21105129, and No. 21375151),
   China Hunan Provincial Science and Technology Department (No.
   2012FJ4139), Central South University for Special Support of the Basic
   Scientific Research Project (No. 2010QZZD007), China Postdoctoral
   Science Foundation (No. 201104511).
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NR 41
TC 60
Z9 60
U1 1
U2 67
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0003-2670
EI 1873-4324
J9 ANAL CHIM ACTA
JI Anal. Chim. Acta
PD MAY 27
PY 2014
VL 827
BP 22
EP 27
DI 10.1016/j.aca.2014.04.008
PG 6
WC Chemistry, Analytical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry
GA AH2BN
UT WOS:000335925800003
PM 24832990
DA 2025-06-11
ER

PT J
AU Lanza, GA
AF Lanza, G. A.
TI Cardiac syndrome X: a critical overview and future perspectives
SO HEART
LA English
DT Review
ID NORMAL CORONARY ANGIOGRAMS; CHEST-PAIN; ANGINA-PECTORIS; ARTERY-DISEASE;
   BLOOD-FLOW; ENDOTHELIAL DYSFUNCTION; MICROVASCULAR ANGINA; VASODILATOR
   RESERVE; NERVE FUNCTION; MENTAL STRESS
AB The classic definition of cardiac syndrome X (CSX) seems inadequate both for clinical and research purposes and should be replaced with one aimed at including a sufficiently homogeneous group of patients with the common plausible pathophysiological mechanism of coronary microvascular dysfunction. More specifically, CSX should be defined as a form of stable effort angina, which, according to careful diagnostic investigation, can reasonably be attributed to abnormalities in the coronary microvascular circulation.
C1 Univ Cattolica Sacro Cuore, Ist Cardiol, I-00168 Rome, Italy.
C3 Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli
RP Lanza, GA (corresponding author), Univ Cattolica Sacro Cuore, Ist Cardiol, Largo A Gemelli 8, I-00168 Rome, Italy.
EM g.a.lanza@inwind.it
RI Lanza, Gaetano/AAC-2660-2019
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NR 43
TC 110
Z9 121
U1 0
U2 7
PU B M J PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 1355-6037
J9 HEART
JI Heart
PD FEB
PY 2007
VL 93
IS 2
BP 159
EP 166
DI 10.1136/hrt.2005.067330
PG 8
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 126NX
UT WOS:000243520700006
PM 16399854
OA Green Published
DA 2025-06-11
ER

PT J
AU Almagro, P
   Soler-Cataluña, JJ
   Huerta, A
   González-Segura, D
   Cosío, BG
AF Almagro, Pere
   Soler-Cataluna, Juan Jose
   Huerta, Arturo
   Gonzalez-Segura, Diego
   Cosio, Borja G.
CA CLAVE Study Investigators
TI Impact of comorbidities in COPD clinical control criteria. The CLAVE
   study
SO BMC PULMONARY MEDICINE
LA English
DT Article
DE COPD: Chronic obstructive pulmonary disease; CAT: COPD assessment test;
   Comorbidities; Clinical control criteria; Exacerbations; Charlson index
ID OBSTRUCTIVE PULMONARY-DISEASE; SYSTEMIC INFLAMMATION; METABOLIC
   SYNDROME; OUTCOMES; RISK; DEPRESSION; ANXIETY; CONSEQUENCES; PREVALENCE;
   VALIDATION
AB Background Chronic obstructive pulmonary disease (COPD) frequently coexists with other chronic diseases, namely comorbidities. They negatively impact prognosis, exacerbations and quality of life in COPD patients. However, no studies have been performed to explore the impact of these comorbidities on COPD clinical control criteria.Research question Determine the relationship between individualized comorbidities and COPD clinical control criteria.Study design and methods Observational, multicenter, cross-sectional study performed in Spain involving 4801 patients with severe COPD (< 50 predicted forced expiratory volume in the first second [FEV1%]). Clinical control criteria were defined by the combination of COPD assessment test (CAT) scores (<= 16 vs >= 17) and exacerbations in the previous three months (none vs >= 1). Binary logistic regression adjusted by age and FEV1% was performed to identify comorbidities potentially associated with the lack of control of COPD. Secondary endpoints were the relationship between individualized comorbidities with COPD assessment test and exacerbations within the last three months.Results Most frequent comorbidities were arterial hypertension (51.2%), dyslipidemia (36.0%), diabetes (24.9%), obstructive sleep apnea-hypopnea syndrome (14.9%), anxiety (14.1%), heart failure (11.6%), depression (11.8%), atrial fibrillation (11.5%), peripheral arterial vascular disease (10.4%) and ischemic heart disease (10.1%). After age and FEV1% adjustment, comorbidities related to lack of clinical control were cardiovascular diseases (heart failure, peripheral vascular disease and atrial fibrillation; p < 0.0001), psychologic disorders (anxiety and depression; all p < 0.0001), metabolic diseases (diabetes, arterial hypertension and abdominal obesity; all p < 0.001), sleep disorders (p < 0.0001), anemia (p = 0.015) and gastroesophageal reflux (p < 0.0001). These comorbidities were also related to previous exacerbations and COPD assessment test scores.Interpretation Comorbidities are frequent in patients with severe COPD, negatively impacting COPD clinical control criteria. They are related to health-related quality of life measured by the COPD assessment test. Our results suggest that comorbidities should be investigated and treated in these patients to improve their clinical control.Take-home points Study question: What is the impact of comorbidities on COPD clinical control criteria?Results: Among 4801 patients with severe COPD (27.5% controlled and 72.5% uncontrolled), after adjustment by age and FEV1%, comorbidities related to lack of clinical control were cardiovascular diseases (heart failure, peripheral vascular disease and atrial fibrillation; p < 0.0001), psychologic disorders (anxiety and depression; p < 0.0001), metabolic diseases (diabetes, arterial hypertension and abdominal obesity; p < 0.001), obstructive sleep apnea-hypopnea syndrome (p < 0.0001), anaemia (p = 0.015) and gastroesophageal reflux (p < 0.0001), which were related to previous exacerbations and COPD assessment test scores.Interpretation: Comorbidities are related to health-related quality of life measured by the COPD assessment test scores and history of exacerbations in the previous three months.Take-home pointsStudy question: What is the impact of comorbidities on COPD clinical control criteria?Results: Among 4801 patients with severe COPD (27.5% controlled and 72.
   5% uncontrolled), after adjustment by age and FEV1%, comorbidities related to lack of clinical control were cardiovascular diseases (heart failure, peripheral vascular disease and atrial fibrillation; p < 0.0001), psychologic disorders (anxiety and depression; p < 0.0001), metabolic diseases (diabetes, arterial hypertension and abdominal obesity; p < 0.001), obstructive sleep apnea-hypopnea syndrome (p < 0.0001), anaemia (p = 0.015) and gastroesophageal reflux (p < 0.0001), which were related to previous exacerbations and COPD assessment test scores.Interpretation: Comorbidities are related to health-related quality of life measured by the COPD assessment test scores and history of exacerbations in the previous three months.Take-home pointsStudy question: What is the impact of comorbidities on COPD clinical control criteria?Results: Among 4801 patients with severe COPD (27.5% controlled and 72.5% uncontrolled), after adjustment by age and FEV1%, comorbidities related to lack of clinical control were cardiovascular diseases (heart failure, peripheral vascular disease and atrial fibrillation; p < 0.0001), psychologic disorders (anxiety and depression; p < 0.0001), metabolic diseases (diabetes, arterial hypertension and abdominal obesity; p < 0.001), obstructive sleep apnea-hypopnea syndrome (p < 0.0001), anaemia (p = 0.015) and gastroesophageal reflux (p < 0.0001), which were related to previous exacerbations and COPD assessment test scores.Interpretation: Comorbidities are related to health-related quality of life measured by the COPD assessment test scores and history of exacerbations in the previous three months.
C1 [Almagro, Pere] H Mutua Terrassa Univ Hosp, Internal Med Dept, Multimorbid Patients Unit, Plaza Doctor Robert 5, Barcelona 08221, Spain.
   [Soler-Cataluna, Juan Jose] Univ Valencia, Hosp Arnau Vilanova Lliria, Dept Pneumol, Med Dept, Valencia, Spain.
   [Soler-Cataluna, Juan Jose] CIBERES, Valencia, Spain.
   [Huerta, Arturo] Emergency Dept, Pulm & Crit Care Div, Clin Sagrada Familia, Barcelona, Spain.
   [Gonzalez-Segura, Diego] Med Dept, Chiesi SAU, Barcelona, Spain.
   [Cosio, Borja G.] H Univ Son Espases Hosp IdISBa, Dept Pneumol, Balear Isl, Palma De Mallorca, Balear Isl, Spain.
   [Cosio, Borja G.] IBERES, Palma De Mallorca, Balear Isl, Spain.
C3 University Hospital Arnau de Vilanova; University of Valencia; CIBER -
   Centro de Investigacion Biomedica en Red; CIBERES
RP Almagro, P (corresponding author), H Mutua Terrassa Univ Hosp, Internal Med Dept, Multimorbid Patients Unit, Plaza Doctor Robert 5, Barcelona 08221, Spain.
EM perealmagro@gmail.com
RI Cosio, Borja/P-4963-2017; Huerta, Arturo/T-9954-2019; Soler-Cataluña,
   Juan/HKV-7421-2023
OI Soler-Cataluna, Juan Jose/0000-0003-1134-0783
FU Chiesi Espana SAU
FX The study described within the paper was sponsored by Chiesi Espana SAU.
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TC 16
Z9 16
U1 2
U2 15
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1471-2466
J9 BMC PULM MED
JI BMC Pulm. Med.
PD JAN 2
PY 2024
VL 24
IS 1
AR 6
DI 10.1186/s12890-023-02758-0
PG 10
WC Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Respiratory System
GA DX2P0
UT WOS:001135319300010
PM 38166965
OA gold
DA 2025-06-11
ER

PT J
AU Eleazu, CO
   Obeten, UN
   Ozor, G
   Njemanze, CC
   Eleazu, KC
   Egedigwe-Ekeleme, AC
   Okorie, UC
   Ogunwa, SC
   Adeolu, A
   Okoh, PFN
   Kalu, AO
   Onyia, CJ
   Onyia, S
   Ossai, P
   Chikezie, CC
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   Obi, V
   Igwe, VM
   Amobi, CA
   Ugada, OJ
   Kalu, WO
   Kanu, S
AF Eleazu, Chinedum O.
   Obeten, Uket N.
   Ozor, Gerald
   Njemanze, Canice C.
   Eleazu, Kate C.
   Egedigwe-Ekeleme, Agatha C.
   Okorie, Uchechukwu C.
   Ogunwa, Shedrack C.
   Adeolu, Adewale, I
   Okoh, Petra-Favour N.
   Kalu, Abigail O.
   Onyia, Chinazaekpere J.
   Onyia, Scholastica
   Ossai, Precious
   Chikezie, Chioma C.
   Odii, Bright C.
   Obi, Valentine
   Igwe, Valeria M.
   Amobi, Chidiebere A.
   Ugada, Ogechukwu J.
   Kalu, Winner O.
   Kanu, Shedrach
TI Tert-butylhydroquinone abrogates fructose-induced insulin resistance in
   rats via mitigation of oxidant stress, NFkB-mediated inflammation in the
   liver but not the skeletal muscle of high fructose drinking rats
SO JOURNAL OF FOOD BIOCHEMISTRY
LA English
DT Article
DE antioxidants; hypertriglyceridemia; inflammation mediators; nutrition
   therapy; insulin resistance
ID INDUCED METABOLIC SYNDROME; TYPE-2 DIABETES-MELLITUS; OXIDATIVE STRESS;
   LIPID-METABOLISM; ANTIOXIDANT STATUS; KAPPA-B; DIET; METFORMIN;
   COMBINATION; DYSFUNCTION
AB The effect of 21% fructose drinking water (FDW) (w/v) on some parameters of metabolic syndrome, hepatic, and skeletal muscular histology of rats was studied using standard techniques. Twenty male albino rats were divided into four groups of 5 rats each in this in vivo study. Group I received distilled water, group 2 received FDW, group 3 received FDW and metformin (300 mg/kg body weight daily, orally), group 4 received FDW and 1% tert-butylhydroquinone feed. FDW changed the serum leptin, triacylglycerol, very low-density lipoprotein, and C-reactive protein levels of the rats, inducing hypertriglyceridemia, oxidative stress, and inflammation in their liver (but not the skeletal muscle) and insulin resistance which were modulated with metformin and tBHQ as corroborated by liver and muscle histology. The study reveals the potentials of metformin and tBHQ in mitigating hepatic and skeletal muscular morphological changes arising from exposure to high fructose drinks. Practical applications There has been an increase in the global consumption of fructose (either as a sweetner in beverages or soft and carbonated drinks) in the last few decades and this has been positively correlated with the global increase in metabolic complications. Regular intake of fructose contributes to the pathogenesis of lipid disorders, oxidant stress, and chronic inflammation, which are linked with the metabolic syndrome components (MetS) (obesity, insulin resistance, and cardiovascular diseases) as well as increased morbidity and mortality. Given that the approaches that have been applied to treat the MetS have not been able to totally arrest it, currenty study which showed that tBHQ abrogated fructose-induced insulin resistance, dyslipidemia, hepatic, and skeletal muscular pathology in the rats places tBHQ in the spotlight as a nutraceutical that could be of relevance in mitigating high dietary fructose-induced hepatic and skeletal muscular pathology.
C1 [Eleazu, Chinedum O.; Obeten, Uket N.; Ozor, Gerald; Njemanze, Canice C.; Egedigwe-Ekeleme, Agatha C.; Okorie, Uchechukwu C.; Ogunwa, Shedrack C.; Okoh, Petra-Favour N.; Kalu, Abigail O.; Onyia, Chinazaekpere J.; Onyia, Scholastica; Ossai, Precious; Chikezie, Chioma C.; Odii, Bright C.; Obi, Valentine; Igwe, Valeria M.; Amobi, Chidiebere A.; Ugada, Ogechukwu J.; Kanu, Shedrach] Alex Ekwueme Fed Univ, Dept Biochem, Nudfu Alike, Ebonyi State, Nigeria.
   [Eleazu, Kate C.] Ebonyi State Univ, Dept Biochem, Abakaliki, Nigeria.
   [Adeolu, Adewale, I] Alex Ekwueme Fed Univ, Dept Agr, Nudfu Aiike, Nigeria.
   [Kalu, Winner O.] Rhema Univ, Dept Biochem, Aba, Nigeria.
RP Eleazu, CO (corresponding author), Alex Ekwueme Fed Univ, Dept Biochem, Nudfu Alike, Ebonyi State, Nigeria.
EM eleazon@yahoo.com
RI Eleazu, Chinedum/AAY-8306-2020
OI Eleazu, Chinedum/0000-0002-1574-0445
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NR 93
TC 5
Z9 5
U1 1
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0145-8884
EI 1745-4514
J9 J FOOD BIOCHEM
JI J. Food Biochem.
PD DEC
PY 2022
VL 46
IS 12
DI 10.1111/jfbc.14473
EA OCT 2022
PG 18
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA 7T2OX
UT WOS:000868808000001
PM 36251589
OA gold
DA 2025-06-11
ER

PT J
AU Sampath, H
   Lloyd, RS
AF Sampath, Harini
   Lloyd, R. Stephen
TI Roles of OGG1 in transcriptional regulation and maintenance of metabolic
   homeostasis
SO DNA REPAIR
LA English
DT Review
DE Base excision repair; Metabolic syndrome; Mitochondrial DNA repair
ID BASE-EXCISION-REPAIR; MITOCHONDRIAL-DNA DAMAGE; HUMAN 8-OXOGUANINE-DNA
   GLYCOSYLASE; PROINFLAMMATORY GENE-EXPRESSION; SER326CYS POLYMORPHISM;
   G-QUADRUPLEX; OXIDATIVE STRESS; CANCER-RISK; HOGG1; ASSOCIATION
AB Cellular damage produced by conditions generating oxidative stress have far-reaching implications in human disease that encompass, but are not restricted to aging, cardiovascular disease, type 2 diabetes, airway inflammation/asthma, cancer, and metabolic syndrome including visceral obesity, insulin resistance, fatty liver disease, and dyslipidemia. Although there are numerous sources and cellular targets of oxidative stress, this review will highlight literature that has investigated downstream consequences of oxidatively-induced DNA damage in both nuclear and mitochondrial genomes. The presence of such damage can in turn, directly and indirectly modulate cellular transcriptional and repair responses to such stressors. As such, the persistence of base damage can serve as a key regulator in coordinated gene-response cascades. Conversely, repair of these DNA lesions serves as both a suppressor of mutagenesis and by inference carcinogenesis, and as a signal for the cessation of ongoing oxidative stress. A key enzyme in all these processes is 8-oxoguanine DNA glycosylase (OGG1), which, via non-catalytic binding to oxidatively-induced DNA damage in promoter regions, serves as a nucleation site around which changes in large-scale regulation of inflammation-associated gene expression can occur. Further, the catalytic function of OGG1 can alter the three-dimensional structure of specialized DNA sequences, leading to changes in transcriptional profiles. This review will concentrate on adverse deleterious health effects that are associated with both the diminution of OGG1 activity via population-specific polymorphic variants and the complete loss of OGG1 in murine models. This mouse model displays diet- and age-related induction of metabolic syndrome, highlighting a key role for OGG1 in protecting against these phenotypes. Conversely, recent investigations using murine models having enhanced global expression of a mitochondrial-targeted OGG1 demonstrate that they are highly resistant to diet-induced disease. These data suggest strategies through which therapeutic interventions could be designed for reducing or limiting adverse human health consequences to these ubiquitous stressors.
C1 [Sampath, Harini] Rutgers State Univ, Dept Nutr Sci, New Brunswick, NJ 08901 USA.
   [Sampath, Harini] Rutgers State Univ, New Jersey Inst Food Nutr & Hlth, New Brunswick, NJ 08901 USA.
   [Lloyd, R. Stephen] Oregon Hlth & Sci Univ, Dept Mol & Med Genet, Oregon Inst Occupat Hlth Sci, Portland, OR 97239 USA.
C3 Rutgers University System; Rutgers University New Brunswick; Rutgers
   University System; Rutgers University New Brunswick; Oregon Health &
   Science University
RP Sampath, H (corresponding author), Rutgers State Univ, Dept Nutr Sci, New Brunswick, NJ 08901 USA.; Sampath, H (corresponding author), Rutgers State Univ, New Jersey Inst Food Nutr & Hlth, New Brunswick, NJ 08901 USA.; Lloyd, RS (corresponding author), Oregon Hlth & Sci Univ, Dept Mol & Med Genet, Oregon Inst Occupat Hlth Sci, Portland, OR 97239 USA.
EM harini.sampath@rutgers.edu; lloydst@ohsu.edu
OI Lloyd, R. Stephen/0000-0001-7273-372X
FU NIH [R01 DK075974, DK100640]; Oregon Institute for Occupational Health
   Sciences; New Jersey Institute for Food, Nutrition, and Health at
   Rutgers University
FX We wish to thank Dr. Vladimir Vartanian who has made invaluable
   contributions to this work. We also wish to thank Drs. Amanda K.
   McCullough, Steve Boldogh, Cindy Burrows, and Scott Ballinger for their
   insightful comments and recommendations on this review. These
   investigations were supported by grants from the NIH, R01 DK075974,
   DK100640. Generous additional support has been provided by the Oregon
   Institute for Occupational Health Sciences and the New Jersey Institute
   for Food, Nutrition, and Health at Rutgers University.
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PG 9
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WE Science Citation Index Expanded (SCI-EXPANDED)
SC Genetics & Heredity; Toxicology
GA JF3PX
UT WOS:000491300600025
PM 31311771
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Kohlwein, SD
AF Kohlwein, Sepp D.
TI Obese and anorexic yeasts: Experimental models to understand the
   metabolic syndrome and lipotoxicity
SO BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
LA English
DT Review
DE Saccharomyces cerevisiae; Schizosaccharomyces pombe; Unfolded protein
   response; TOR signaling; AMP-activated protein kinase; Apoptosis; Fatty
   acid toxicity; Lipolysis; Lipidomics
ID UNFOLDED PROTEIN RESPONSE; MG2+-DEPENDENT PHOSPHATIDATE PHOSPHATASE;
   ENDOPLASMIC-RETICULUM STRESS; POLYUNSATURATED FATTY-ACIDS;
   SACCHAROMYCES-CEREVISIAE; CELL-DEATH; FISSION YEAST; PHOSPHOLIPID
   BIOSYNTHESIS; LIPID-METABOLISM; SCHIZOSACCHAROMYCES-POMBE
AB Lipotoxicity is the pathological consequence of lipid overflow in non-adipose tissue, mediated through reactive lipid moieties which may even lead to lipid-induced cell death (lipoapoptosis). This derailment of cellular and organismal fat homeostasis is the consequence of obesity due to continued over-feeding, and contributes substantially to the pathogenesis of insulin resistance, type 2 diabetes mellitus and cardiovascular disease, which are all components of the metabolic syndrome. Now, does yeast, a single-celled eukaryote, ever suffer from the metabolic syndrome and what can we potentially learn from studies in this organism about the underlying molecular mechanism that lead to lipid-associated pathologies in human cells? In this review I will summarize the remarkably conserved metabolic and regulatory processes relevant to establishing cellular energy and lipid homeostasis, as well as recent findings that provide detailed insights into the molecular mechanisms underlying fat-induced cellular malfunction and cell death, with potential implications also for mammalian cells. (C) 2010 Elsevier B.V. All rights reserved.
C1 Graz Univ, Inst Mol Biosci, A-8010 Graz, Austria.
C3 University of Graz
RP Kohlwein, SD (corresponding author), Graz Univ, Inst Mol Biosci, Humboldtstr 50-II, A-8010 Graz, Austria.
EM sepp.kohlwein@uni-graz.at
OI Kohlwein, Sepp Dieter/0000-0002-1030-0598
FU Austrian Science Funds FWF [SFB F3005]; Austrian Federal Ministry for
   Science and Research
FX I would like to thank Klaus Natter, Oksana Tehlivets and Pamela Padilla
   for critically reading the manuscript and helpful comments. Work in our
   laboratory is supported by grants from the Austrian Science Funds FWF
   (Project SFB F3005-Lipotox and PhD program Molecular Enzymology) and the
   Austrian Federal Ministry for Science and Research (Project GOLD -
   Genomics Of Lipid-associated Disorders) in the framework of the GEN-AU
   program.
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NR 97
TC 38
Z9 45
U1 0
U2 15
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1388-1981
EI 0006-3002
J9 BBA-MOL CELL BIOL L
JI Biochim. Biophys. Acta Mol. Cell Biol. Lipids
PD MAR
PY 2010
VL 1801
IS 3
SI SI
BP 222
EP 229
DI 10.1016/j.bbalip.2009.12.016
PG 8
WC Biochemistry & Molecular Biology; Biophysics; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Cell Biology
GA 568YT
UT WOS:000275563300004
PM 20056167
DA 2025-06-11
ER

PT J
AU Karakaya, P
   Ozdemir, B
   Mert, M
   Okuturlar, Y
AF Karakaya, Pinar
   Ozdemir, Bahar
   Mert, Meral
   Okuturlar, Yildiz
TI Relation of Paraoxonase 1 Activity with Biochemical Variables, Brachial
   Artery Intima-Media Thickness in Patients with Diabetes with or without
   Obesity
SO OBESITY FACTS
LA English
DT Article
DE BMI; Cardiometabolic risk; Diabetes mellitus; Obesity; Paraoxonase 1
   activity; Brachial artery intima-media thickness
ID CORONARY-HEART-DISEASE; LOW-DENSITY-LIPOPROTEIN; SERUM PARAOXONASE;
   METABOLIC SYNDROME; OXIDATIVE STRESS; ENZYME-ACTIVITY;
   MYOCARDIAL-INFARCTION; NONDIABETIC SUBJECTS; HDL-CHOLESTEROL; MELLITUS
AB Aim: The sodium-sparing effect of insulin leads to increase in total sodium pool of the body which is a chronic stimulus for atrial natriuretic peptide (ANP). In our study we aimed to determine the relationship between ANP and microvascular complications of diabetes. Methods: 60 patients, 30-70 years old, with the diagnosis of type 2 diabetes mellitus (DM) are enrolled into the study. Patients with a chronic disease other than DM are excluded. Blood samples for routine biochemical tests are taken after at least 12 h fasting at 8-9 am. Blood samples for glucose and insulin levels are taken 2 h after a standard meal. Blood tubes with EDTA are used for ANP levels. The microvascular complications of the patients are evaluated. Results: 32 of the patients had microvascular complications. Age, BMI, waist and hip circumferences, and ANP levels were significantly higher in the group with microvascular complications. There were no significant differences in waist-to-hip ratio, blood glucose, HbA1c, fasting insulin, postprandial insulin, fasting HOMA, postprandial HOMA as well as sodium, potassium, magnesium, calcium and lipid levels between the two groups. When the relationship between ANP and obesity, retinopathy, neuropathy, nephropathy, diabetes time, HbA1c, or sex are evaluated separately, the only significant parameters related to ANP were obesity and retinopathy. Conclusion: In our study we have found that there was a significant relationship between ANP levels and microvascular complications of diabetes. Future studies are needed to show if ANP is the stimulus of microvascular complication development/progression or only an epiphenomenon. (C) 2018 The Author(s) Published by S. Karger GmbH, Freiburg
C1 [Karakaya, Pinar; Ozdemir, Bahar; Mert, Meral; Okuturlar, Yildiz] Bakirkoy Dr Sadi Konuk Training & Res Hosp, Dept Endocrinol & Metab, TR-34100 Istanbul, Turkey.
C3 Bakirkoy Dr. Sadi Konuk Research & Training Hospital
RP Karakaya, P (corresponding author), Bakirkoy Dr Sadi Konuk Training & Res Hosp, Dept Endocrinol & Metab, TR-34100 Istanbul, Turkey.
EM drpinarkarakaya@hotmail.com
RI Mert, Meral/KXR-1439-2024; Okuturlar, Yildiz/X-3647-2018
OI Mert, Meral/0000-0003-3431-0915
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NR 40
TC 9
Z9 9
U1 0
U2 5
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1662-4025
EI 1662-4033
J9 OBESITY FACTS
JI Obes. Facts
PY 2018
VL 11
IS 1
BP 56
EP 66
DI 10.1159/000486513
PG 11
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA FZ0TQ
UT WOS:000427286300006
PM 29439274
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Lin, CP
   Lin, WT
   Leu, HB
   Wu, TC
   Chen, JW
AF Lin, CP
   Lin, WT
   Leu, HB
   Wu, TC
   Chen, JW
TI Differential mononuclear cell activity and endothelial inflammation in
   coronary artery disease and cardiac syndrome X
SO INTERNATIONAL JOURNAL OF CARDIOLOGY
LA English
DT Article
DE atherosclerosis; inflammation; mononuclear cell; superoxide; syndrome X
ID INTERCELLULAR-ADHESION MOLECULE-1; CYTOKINE-INDUCED EXPRESSION;
   LOW-DENSITY-LIPOPROTEIN; E-SELECTIN; OXIDATIVE STRESS; VASCULAR CELL;
   MICROVASCULAR ANGINA; HEART-DISEASE; CHEST PAIN; CAROTID ATHEROSCLEROSIS
AB Background: Circulating mononuclear cells could be activated with endothelial inflammation in patients with coronary artery disease (CAD). In some patients with normal coronary angiograms, myocardial ischemia could also present with coronary microvascular dysfunction (cardiac syndrome X). This study was undertaken to investigate whether mononuclear cell activation and endothelial inflammation can present in syndrome X patients. Methods: We evaluated the biochemical parameters, circulating soluble adhesion molecules, circulating superoxide free radicals, and mononuclear cell activity in 32 patients with syndrome X, 34 with angiographically documented CAD, and 17 age- and gender-matched healthy control subjects. Results: Compared to that in control subjects, plasma high-density lipoprotein was reduced (P<0.001) and insulin to glucose ratio increased (P=0.02) in CAD patients. Circulating level of soluble intracellular adhesion molecule-1 was significantly higher in both syndrome X and CAD patients than in control subjects (P<0.01), whereas the levels of soluble vascular cell adhesion molecule (P=0.02) and von Willebrand factor (P=0.01) were increased in CAD patients only. The peak (P<0.001) and total counts of superoxide free radicals in whole blood (P<0.001) was significantly higher in syndrome X patients than in the other two groups. However, phorbol-12-myristate-13-acetate-induced superoxide free radical generation of mononuclear cells was increased in CAD (10.5+/-4.6%, P=0.01) but not in syndrome X patients (8.7+/-2.0%) as compared with control subjects (7.7+/-0.5%). Conclusions: The results indicated that the activity of mononuclear cells was increased with significant endothelial inflammation and injury in CAD patients. In syndrome X patients, though circulating superoxide free radicals were increased, there was minimal endothelial inflammation without mononuclear cell activation. The relatively preserved lipid and metabolic profiles might contribute to less vascular inflammation in syndrome X patients. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
C1 Taipei Vet Gen Hosp, Dept Pathol, Taipei 11217, Taiwan.
   Vet Gen Hosp, Dept Internal Med, Div Cardiol, Taipei 11217, Taiwan.
   Natl Yang Ming Univ, Sch Med, Cardiovasc Res Ctr, Taipei 11217, Taiwan.
C3 Taipei Veterans General Hospital; National Yang Ming Chiao Tung
   University
RP Chen, JW (corresponding author), Taipei Vet Gen Hosp, Dept Pathol, 201 Sect 2 Shih Pai Rd, Taipei 11217, Taiwan.
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NR 46
TC 40
Z9 42
U1 0
U2 3
PU ELSEVIER SCI IRELAND LTD
PI CLARE
PA CUSTOMER RELATIONS MANAGER, BAY 15, SHANNON INDUSTRIAL ESTATE CO, CLARE,
   IRELAND
SN 0167-5273
J9 INT J CARDIOL
JI Int. J. Cardiol.
PD MAY
PY 2003
VL 89
IS 1
BP 53
EP 62
DI 10.1016/S0167-5273(02)00428-X
PG 10
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 683TL
UT WOS:000183165700006
PM 12727005
DA 2025-06-11
ER

PT J
AU Miler, M
   Nikolac, N
   Segulja, D
   Maslac, SK
   Celap, I
   Altabas, K
   Sefer, S
   Simundic, AM
AF Miler, M.
   Nikolac, N.
   Segulja, D.
   Maslac, S. Kackov
   Celap, I.
   Altabas, K.
   Sefer, S.
   Simundic, A. M.
TI Is peritoneal dialysis causing a measurable burden of inflammatory and
   endothelial injury on top of metabolic syndrome?
SO JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
LA English
DT Article
DE Adipokines; Endothelial impairment; Inflammation; Metabolic syndrome;
   Oxidative stress; Peritoneal dialysis
ID CHRONIC KIDNEY-DISEASE; VISFATIN; ASSOCIATION; DYSFUNCTION; MARKERS;
   LIGAND; RISK
AB Purpose Low-grade chronic inflammation is present in patients on peritoneal dialysis (PD) and in metabolic syndrome (MS). Due to possible greater endothelial changes in dialyzed patients, inflammatory response and oxidative stress are probably stronger in patients on PD. The objective of the study was to investigate possible in between adipokines, inflammatory, endothelial and oxidative stress markers between MS patients and patients on PD.
   Methods Concentrations of adipokines (leptin, resistin), inflammatory markers [interleukin-6 (IL-6), soluble tumor necrosis factor alpha receptor (sTNF-R), myeloperoxidase (MPO), monocyte chemoattractant protein 1 (MCP-1)] and endothelial markers [soluble intracellular adhesion molecule- 1 (sICAM-1), soluble CD40 ligand (sCD40L)] were determined in 55 MS patients and 18 patients on PD, with flow cytometry, and visfatin concentration was measured with ELISA. Routine biochemistry parameters were measured on Beckman Coulter AU2700 analyzer.
   Results Patients on PD have significantly higher concentration of: CRP [6.5 (3.7-12.1) versus 2.6 (1.3-4.0) mg/L, P < 0.001], IL- 6 [13.83 (8.48- 31.31) versus 2.05 (0.67-4.11) pg/mL, P < 0.001], MCP- 1 [2172.28 (1563.84-2922.77) versus 1353.58 (1166.33-1961.70) pg/mL, P = 0.023], sTNF-R [18.25 (12.81-25.22) versus 1.23 (0.89-1.43) ng/mL, P < 0.001] and sICAM-1 [830.03 (599.21-967.02) versus 463.85 (315.25-751.71) ng/mL, P = 0.006] than subjects with MS. MS patients have higher concentrations of MPO [175.47 (120.15-231.67) versus 101.76 (53.55-186.06) ng/mL, P = 0.016] and visfatin [1.5 (0.9-2.3) versus 0.9 (0.6-1.6) ng/mL, P = 0.013].
   Conclusion In patients on PD, inflammatory reaction is higher than in patients with MS. On the contrary, patients with MS have stronger oxidative stress response and adipose tissue activity caused probably by the chronic low level of inflammation and underlying metabolic disorders.
C1 [Miler, M.; Nikolac, N.; Celap, I.] Univ Hosp, Sestre Milosrdnice Med Sch, Univ Dept Chem, Zagreb, Croatia.
   [Segulja, D.] Univ Hosp Ctr Zagreb, Dept Lab Diagnost, Zagreb, Croatia.
   [Maslac, S. Kackov] Policlin Bonifarm, Med Biochem Lab, Zagreb, Croatia.
   [Altabas, K.; Sefer, S.] Univ Hosp Sestre Milosrdnice, Sch Med, Dept Nephrol & Dialysis, Zagreb, Croatia.
   [Simundic, A. M.] Univ Hosp Sveti Duh, Dept Med Lab Diagnost, Zagreb, Croatia.
C3 University of Zagreb; UNIVERSITY ZAGREB HOSPITAL; University of Zagreb
RP Miler, M (corresponding author), Univ Hosp, Sestre Milosrdnice Med Sch, Univ Dept Chem, Zagreb, Croatia.
EM marijana.miler@gmail.com
RI Celap, Ivana/D-1964-2017
OI Celap, Ivana/0000-0002-3982-5777
FU Ministry of Science, Education and Sports, Republic of Croatia
   [134-1340227-0200]
FX This study was supported by Ministry of Science, Education and Sports,
   Republic of Croatia, project Number: 134-1340227-0200.
CR [Anonymous], HARRISONS NEPHROLOGY
   [Anonymous], OXID MED CELL LONGEV
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NR 28
TC 5
Z9 5
U1 0
U2 3
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0391-4097
EI 1720-8386
J9 J ENDOCRINOL INVEST
JI J. Endocrinol. Invest.
PD FEB
PY 2017
VL 40
IS 2
BP 163
EP 168
DI 10.1007/s40618-016-0540-7
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA EO7OR
UT WOS:000396880500006
PM 27600388
DA 2025-06-11
ER

PT J
AU Gounden, V
   Devaraj, S
   Jialal, I
AF Gounden, Verena
   Devaraj, Sridevi
   Jialal, Ishwarlal
TI The role of the triglyceride-glucose index as a biomarker of
   cardio-metabolic syndromes
SO LIPIDS IN HEALTH AND DISEASE
LA English
DT Review
DE Triglyceride-glucose index; Cardiovascular disease; Metabolic syndrome;
   Insulin resistance; Diabetes
ID TYPE-2 DIABETES-MELLITUS; INSULIN-RESISTANCE; CARDIOVASCULAR-DISEASE;
   TYG INDEX; EVENTS; RISK; PRODUCT; HOMA
AB BackgroundThe Triglyceride-glucose (TyG) index represents a simple, cost-effective, and valid proxy for insulin resistance. This surrogate marker has also been proposed as a predictor of metabolic and cardiovascular disease (CVD). In this descriptive review, we aimed to assess the utility of the TyG index as a predictive biomarker of cardiometabolic diseases.MethodsA search was conducted in PubMed, and Web of Science to identify cross-sectional and more importantly prospective studies examining the use of the TyG index as a predictive biomarker. The following terms were utilized in addition to the TyG index: "insulin resistance", "metabolic syndrome", "diabetes"; "cardiovascular diseases".ResultsThis descriptive review included thirty prospective studies in addition to cross-sectional studies. Following adjustment for confounding variables, an elevated TyG index was associated with a significantly increased risk for the development of Metabolic Syndrome (MetS), Type 2 Diabetes, hypertension, and CVD. Also in limited studies, the TyG index was associated with endothelial dysfunction, increased oxidative stress and a pro-inflammatory phenotype.ConclusionOverall, our findings support the use of the TyG index as a valid biomarker to assess the risk of developing MetS, T2DM, as well as atherosclerotic cardiovascular disease.
C1 [Gounden, Verena] Univ Hosp Galway, Dept Clin Biochem, Galway H91YR71, Ireland.
   [Devaraj, Sridevi] Baylor Coll Med, Houston, TX USA.
   [Jialal, Ishwarlal] UC Davis Sch Med, Internal Med & Pathol, 2616 Hepworth Dr, Davis, CA 95618 USA.
C3 Baylor College of Medicine; University of California System; University
   of California Davis
RP Jialal, I (corresponding author), UC Davis Sch Med, Internal Med & Pathol, 2616 Hepworth Dr, Davis, CA 95618 USA.
EM kjialal@gmail.com
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NR 84
TC 6
Z9 6
U1 6
U2 6
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1476-511X
J9 LIPIDS HEALTH DIS
JI Lipids Health Dis.
PD DEC 23
PY 2024
VL 23
IS 1
AR 416
DI 10.1186/s12944-024-02412-6
PG 13
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA Q1Y6L
UT WOS:001382728100001
PM 39716258
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Schiano, C
   Grimaldi, V
   Scognamiglio, M
   Costa, D
   Soricelli, A
   Nicoletti, GF
   Napoli, C
AF Schiano, Concetta
   Grimaldi, Vincenzo
   Scognamiglio, Michele
   Costa, Dario
   Soricelli, Andrea
   Nicoletti, Giovanni Francesco
   Napoli, Claudio
TI Soft drinks and sweeteners intake: Possible contribution to the
   development of metabolic syndrome and cardiovascular diseases.
   Beneficial or detrimental action of alternative sweeteners?
SO FOOD RESEARCH INTERNATIONAL
LA English
DT Review
DE Cardiovascular disease; Metabolic syndrome; Nutrition; Soft drink;
   Alternative sweetener
AB The rapid increase in obesity, metabolic syndrome, and cardiovascular diseases (CVDs) has been related to the rise in sugar-added foods and sweetened beverages consumption. An interesting approach has been to replace sugar with alternative sweeteners (AS), due to their impact on public health. Preclinical and clinical studies, which analyze the safety of AS intake, are still limited. Major pathogenic mechanisms of these substances include ROS and AGEs formation. Indeed, endothelial dysfunction involving in the pathogenesis of micro-and macro-vascular diseases is mitochondrial dysfunction dependent. Hyperglycemia and endoplasmic reticulum stress together produce ROS, contributing to the development and progression of cardiovascular complications during type 2 diabetes (T2D), thus causing oxidative changes and direct damage of lipids, proteins, and DNA. Epide-miological studies in healthy subjects have suggested that the consumption of artificial AS can promote CV complications, such as glucose intolerance and predisposition to the onset of T2D, whereas natural AS could reduce hyperglycemia, improve lipid metabolism and have antioxidant effects. Long-term prospective clinical randomized studies are needed to evaluate precisely whether exposure to alternative sugars can have clinical implications on natural history and clinical outcomes, especially in children or during the gestational period through breast milk.
C1 [Schiano, Concetta; Napoli, Claudio] Univ Campania L Vanvitelli, Dept Adv Med & Surg Sci DAMSS, Naples, Italy.
   [Grimaldi, Vincenzo; Soricelli, Andrea; Napoli, Claudio] IRCCS SDN, Naples, Italy.
   [Scognamiglio, Michele; Costa, Dario; Napoli, Claudio] Azienda Univ Policlin AOU, Clin Dept Internal Med & Specialist Units, Div Clin Immunol & Irumunohernatol Transfus Med &, Reg Reference Lab Transplant Immunol LIT, Naples, Italy.
   [Soricelli, Andrea] Univ Naples Parthenope, Dept Exercise & Wellness Sci, Naples, Italy.
   [Nicoletti, Giovanni Francesco] Univ Campania L Vanvitelli, Multidisciplinary Dept Med Surg & Dent Sci, Plast Surg Unit, Naples, Italy.
C3 Universita della Campania Vanvitelli; IRCCS Istituto di Ricerca
   Diagnostica e Nucleare (SDN); Parthenope University Naples; Universita
   della Campania Vanvitelli
RP Schiano, C (corresponding author), Univ Campania L Vanvitelli, Dept Adv Med & Surg Sci, I-80138 Naples, Italy.
EM concetta.schiano@unicampania.it
RI soricelli, andrea/C-1133-2009; Schiano, Concetta/GOE-4310-2022
FU National Research Competitive Grant (PRIN) from Ministery for University
   and Research, Italy [F8ZB89]; MUR Italy; Ministery of Health, Italy
   [GR-2016-02362046]; PON-AIM of the Ministery for University and
   Research, Italy
FX This review was funded by National Research Competitive Grant (PRIN
   supporting grant no. F8ZB89) from Ministery for University and Research,
   Italy (to Professor Claudio Napoli, M.D., Ph.D.); by Research
   Competitive Grant "VALERE:2020" (to Dr. Schiano Concetta, Ph.D.) from
   MUR Italy; by National Research Competitive Grant GR-2016-02362046 (to
   Dr. Vincenzo Grimaldi, Ph.D.) from Ministery of Health, Italy. The
   funders had no role in study design, data collection and analysis,
   decision to publish, or preparation of the manuscript. CS, Pharm.D,
   Ph.D. is a Researcher type A supported by PON-AIM of the Ministery for
   University and Research, Italy.
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NR 165
TC 26
Z9 28
U1 5
U2 65
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0963-9969
EI 1873-7145
J9 FOOD RES INT
JI Food Res. Int.
PD APR
PY 2021
VL 142
AR 110220
DI 10.1016/j.foodres.2021.110220
EA FEB 2021
PG 14
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA RL7OM
UT WOS:000639157600003
PM 33773688
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Jahandideh, F
   Wu, JP
AF Jahandideh, Forough
   Wu, Jianping
TI Perspectives on the Potential Benefits of Antihypertensive Peptides
   towards Metabolic Syndrome
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE antihypertensive peptides; glucose intolerance; inflammation; insulin
   resistance; metabolic syndrome; obesity
ID RENIN-ANGIOTENSIN SYSTEM; TYPE-2 DIABETES-MELLITUS; VAL-PRO-PRO;
   EGG-WHITE HYDROLYSATE; MILK-DERIVED PEPTIDES; C-REACTIVE PROTEIN;
   INSULIN-RESISTANCE; BLOOD-PRESSURE; OXIDATIVE STRESS; BIOACTIVE PEPTIDES
AB In addition to the regulation of blood pressure, the renin-angiotensin system (RAS) also plays a key role in the onset and development of insulin resistance, which is central to metabolic syndrome (MetS). Due to the interplay between RAS and insulin resistance, antihypertensive compounds may exert beneficial effects in the management of MetS. Food-derived bioactive peptides with RAS blocking properties can potentially improve adipose tissue dysfunction, glucose intolerance, and insulin resistance involved in the pathogenesis of MetS. This review discusses the pathophysiology of hypertension and the association between RAS and pathogenesis of the MetS. The effects of bioactive peptides with RAS modulating effects on other components of the MetS are discussed. While the in vivo reports on the effectiveness of antihypertensive peptides against MetS are encouraging, the exact mechanism by which these peptides infer their effects on glucose and lipid handling is mostly unknown. Therefore, careful design of experiments along with standardized physiological models to study the effect of antihypertensive peptides on insulin resistance and obesity could help to clarify this relationship.
C1 [Jahandideh, Forough; Wu, Jianping] Univ Alberta, Fac Agr Life & Environm Sci, Dept Agr Food & Nutr Sci, Edmonton, AB T6G 2P5, Canada.
   [Jahandideh, Forough; Wu, Jianping] Univ Alberta, Fac Med & Dent, Cardiovasc Res Ctr, Edmonton, AB T6G 2S2, Canada.
C3 University of Alberta; University of Alberta
RP Jahandideh, F; Wu, JP (corresponding author), Univ Alberta, Fac Agr Life & Environm Sci, Dept Agr Food & Nutr Sci, Edmonton, AB T6G 2P5, Canada.; Jahandideh, F; Wu, JP (corresponding author), Univ Alberta, Fac Med & Dent, Cardiovasc Res Ctr, Edmonton, AB T6G 2S2, Canada.
EM jahandid@ualberta.ca; jwu3@ualberta.ca
RI Wu, Jianping/H-9150-2012; Jahandideh, Forough/M-4648-2019
OI Jahandideh, Forough/0000-0001-9731-0854
FU Alberta Agriculture and Forestry; Egg Farmers of Alberta; Natural
   Sciences and Engineering Research Council (NSERC) of Canada; Egg Farmers
   of Canada
FX This research was supported by grants from Alberta Agriculture and
   Forestry, Egg Farmers of Canada, Egg Farmers of Alberta, and Natural
   Sciences and Engineering Research Council (NSERC) of Canada to J. Wu.
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NR 173
TC 24
Z9 25
U1 1
U2 18
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD MAR
PY 2020
VL 21
IS 6
AR 2192
DI 10.3390/ijms21062192
PG 23
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA LJ0UU
UT WOS:000529890200288
PM 32235782
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Sabe, AA
   Sadek, AA
   Elmadhun, NY
   Dalal, RS
   Robich, MP
   Bianchi, C
   Sellke, FW
AF Sabe, Ashraf A.
   Sadek, Ahmed A.
   Elmadhun, Nassrene Y.
   Dalal, Rahul S.
   Robich, Michael P.
   Bianchi, Cesario
   Sellke, Frank W.
TI Investigating the Effects of Resveratrol on Chronically Ischemic
   Myocardium in a Swine Model of Metabolic Syndrome: A Proteomics Analysis
SO JOURNAL OF MEDICINAL FOOD
LA English
DT Article
DE metabolic syndrome; ischemic heart disease; proteomics; remodeling;
   metabolism; resveratrol
ID CORONARY-ARTERY-DISEASE; MUTATION; STRESS; MICE
AB Resveratrol has been shown to improve cardiac perfusion and ventricular function after chronic ischemic injury. Using proteomic analysis, we sought to objectively investigate potential mechanisms, by which resveratrol exerts its cardioprotective effects in the setting of metabolic syndrome and chronic myocardial ischemia. Yorkshire swine were divided into two groups based on diet: high cholesterol (n=7) or a high-cholesterol diet with supplemental resveratrol (n=6). Four weeks later, all animals underwent surgical placement of an ameroid constrictor to their left circumflex artery. Diets were continued for another 7 weeks, and then the ischemic myocardium was harvested for proteomics analysis. Proteomic analysis identified 669 common proteins between the two groups. Of these proteins, 76 were statistically different, of which 41 were characterized (P<.05). Pathway analysis demonstrated that in animals supplemented with resveratrol, there was a downregulation in several proteins involved with mitochondrial dysfunction, cell death, and unfavorable cardiac remodeling. Furthermore, there was an upregulation in proteins involved in free radical elimination. We conclude that resveratrol supplementation significantly alters several critical protein markers in the chronically ischemic myocardium. Further investigation of these proteins may help elucidate the mechanisms by which resveratrol exerts its cardioprotective effects.
C1 [Sabe, Ashraf A.; Sadek, Ahmed A.; Elmadhun, Nassrene Y.; Dalal, Rahul S.; Robich, Michael P.; Bianchi, Cesario; Sellke, Frank W.] Brown Univ, Warren Alpert Sch Med, Div Cardiothorac Surg, Cardiovasc Res Ctr, Providence, RI 02905 USA.
C3 Brown University
RP Sellke, FW (corresponding author), Brown Univ, Warren Alpert Sch Med, Div Cardiothorac Surg, Cardiovasc Res Ctr, 2 Dudley St,MOC 360, Providence, RI 02905 USA.
EM fsellke@lifespan.org
RI bianchi, cesario/H-6238-2012; Dalal, Rahul/AAH-1965-2021
OI Dalal, Rahul/0000-0003-4622-8441
FU National Heart, Lung, and Blood Institute [R01HL46716, R01HL69024,
   R01HL85647]; NIH [5T32-HL094300-03, T32-HL0074]
FX Funding for this research was provided by the National Heart, Lung, and
   Blood Institute (R01HL46716, R01HL69024, and R01HL85647, Dr. F.W.S.),
   NIH Training grant 5T32-HL094300-03 (Dr. A.A.S. and Dr. N.Y.E.), and NIH
   Training grant T32-HL0074 (Dr. M.P.R.).
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NR 18
TC 11
Z9 11
U1 0
U2 6
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1096-620X
EI 1557-7600
J9 J MED FOOD
JI J. Med. Food
PD JAN 1
PY 2015
VL 18
IS 1
BP 60
EP 66
DI 10.1089/jmf.2014.0036
PG 7
WC Chemistry, Medicinal; Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Food Science & Technology; Nutrition &
   Dietetics
GA AY2BL
UT WOS:000347393400007
PM 25089828
OA Green Published
DA 2025-06-11
ER

PT J
AU Bungau, SG
   Tit, DM
   Vesa, CM
   Abid, A
   Szilagyi, DV
   Radu, AF
   Bungau, AF
   Tarce, AG
   Behl, T
   Stoicescu, M
   Brisc, CM
   Gitea, D
   Nechifor, AC
   Endres, L
AF Bungau, Simona Gabriela
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   Vesa, Cosmin Mihai
   Abid, Areha
   Szilagyi, Denisa-Viola
   Radu, Andrei-Flavius
   Bungau, Alexa Florina
   Tarce, Alexandra Georgiana
   Behl, Tapan
   Stoicescu, Manuela
   Brisc, Cristina Mihaela
   Gitea, Daniela
   Nechifor, Aurelia Cristina
   Endres, Laura
TI Non-conventional therapeutical approaches to acne vulgaris related to
   its association with metabolic disorders
SO EUROPEAN JOURNAL OF PHARMACOLOGY
LA English
DT Article
DE Acne vulgaris; Insulin resistance; Metabolic syndrome; Pathogenesis;
   Dietary and therapeutical interventions; Non-conventional therapeutical
   approach
ID GLYCEMIC-LOAD DIET; LOW-FAT DIET; INSULIN-RESISTANCE;
   PROPIONIBACTERIUM-ACNES; ORAL ZINC; OXIDATIVE STRESS; VITAMIN-A;
   ANTIMICROBIAL ACTIVITY; INFLAMMATORY RESPONSE; CHEMICAL-COMPOSITION
AB The ever-increasing frequency of metabolic syndrome (MetS) is still a major challenge of the public health care system, worldwide. In recent years, researchers have been drawn to the uncommon (at first look) link between skin illnesses and MetS. Because of the pro-inflammatory mechanisms and insulin resistance (IR) that are upregulated in metabolic syndrome, many skin disorders are correlated to metabolic dysfunctions, including acne vulgaris. A comprehensive understanding of the link between MetS and acne vulgaris may contribute to the development of new treatment strategies. The current review focuses on dietary and therapeutic interventions and assesses the effect of various approaches such as improving diet by avoiding certain food products (i.e., milk and chocolate) or increasing the intake of others (i.e., food products rich in omega-3 fatty acids), metformin administration, therapy with plant extracts, plant essential oils, and probiotic supplementation on the improvement of certain acne vulgaris severity parameters. These therapeutic approaches, when combined with allopathic treatment, can improve the patients' quality of life.
C1 [Bungau, Simona Gabriela; Tit, Delia Mirela; Gitea, Daniela] Univ Oradea, Fac Med & Pharm, Dept Pharm, Oradea 410028, Romania.
   [Bungau, Simona Gabriela; Tit, Delia Mirela; Szilagyi, Denisa-Viola; Radu, Andrei-Flavius] Univ Oradea, Doctoral Sch Biol & Biomed Sci, Oradea 410087, Romania.
   [Vesa, Cosmin Mihai] Univ Oradea, Fac Med & Pharm, Dept Preclin Disciplines, Oradea 410073, Romania.
   [Abid, Areha] Univ Saskatchewan, Coll Agr & Bioresources, Dept Food & Bioprod Sci, Saskatoon, SK, Canada.
   [Bungau, Alexa Florina; Tarce, Alexandra Georgiana] Univ Oradea, Fac Med & Pharm, Oradea 410073, Romania.
   [Behl, Tapan] Chitkara Univ, Chitkara Coll Pharm, Dept Pharmacol, Rajpura 140401, Punjab, India.
   [Stoicescu, Manuela; Brisc, Cristina Mihaela] Univ Oradea, Fac Med & Pharm, Dept Med Disciplines, Oradea 410073, Romania.
   [Nechifor, Aurelia Cristina] Univ Politehn Bucuresti, Analyt Chem & Environm Engn Dept, Bucharest 011061, Romania.
   [Endres, Laura] Univ Oradea, Fac Med & Pharm, Dept Psychoneurosci & Recovery, Oradea 410073, Romania.
C3 University of Oradea; University of Oradea; University of Oradea;
   University of Saskatchewan; University of Oradea; Chitkara University,
   Punjab; University of Oradea; National University of Science &
   Technology POLITEHNICA Bucharest; University of Oradea
RP Tit, DM (corresponding author), Univ Oradea, Fac Med & Pharm, Dept Pharm, Oradea 410028, Romania.; Vesa, CM (corresponding author), Univ Oradea, Fac Med & Pharm, Dept Preclin Disciplines, Oradea 410073, Romania.
EM simonabungau@gmail.com; mirela_tit@yahoo.com; v_cosmin_15@yahoo.com;
   areha.abid786@gmail.com; deni02viola@gmail.com;
   andreiflavius.radu@gmail.com; pradaalexaflorina@gmail.com;
   tarce_alexandra@yahoo.com; tapanbehl31@gmail.com;
   manuela_stoicescu@yahoo.com; briscristina@yahoo.com;
   gitea_daniela@yahoo.co.uk; aureliacristinanechifor@gmail.com;
   laura_endres@yahoo.com
RI Bungau, Simona Gabriela/C-1831-2015; DANIELA, GITEA/AAL-7932-2020; Radu,
   Andrei-Flavius/AAD-3129-2022; Szilagyi, Denisa Viola/AHA-6618-2022; Tit,
   Delia/AAT-5032-2020; Brisc, Mihaela Cristina/AAC-9003-2022; Stoicescu,
   Manuela/AAC-9008-2022; Bungau, Alexa/AGY-4752-2022; Endres,
   Laura/AAY-5100-2020; Alexandra Georgiana, Tarce/AHC-5764-2022; Mihai,
   Vesa/AAE-5495-2019; Behl, Tapan/W-3523-2019; Aurelia Cristina,
   Nechifor/AAD-4286-2022
OI RADU, ANDREI-FLAVIUS/0000-0002-7625-8177; Tit, Delia
   Mirela/0000-0002-0296-6592; /0000-0003-3236-1292; Cosmin Mihai,
   Vesa/0000-0001-5071-9601; Szilagyi, Denisa Viola/0000-0002-7491-1099;
   Bungau, Alexa/0000-0002-7300-3646; DANIELA, GITEA/0000-0002-1052-8496
FU Romanian Ministry of Research,Innovation and Digitisation through
   Programme 1 - Development of the National Research and Development
   System, Subprogramme 1.2 - Institutional Performance - Projects [29
   PFE/30.12.2021]; Oradea, Romania
FX This research was supported by the Romanian Ministry of
   Research,Innovation and Digitisation through Programme 1 - Development
   of the National Research and Development System, Subprogramme 1.2 -
   Institutional Performance - Projects for funding the excellence in RDI,
   Contract No. 29 PFE/30.12.2021 with University of Oradea, Oradea,
   Romania.
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NR 176
TC 7
Z9 7
U1 1
U2 30
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0014-2999
EI 1879-0712
J9 EUR J PHARMACOL
JI Eur. J. Pharmacol.
PD MAY 15
PY 2022
VL 923
AR 174936
DI 10.1016/j.ejphar.2022.174936
EA APR 2022
PG 12
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 1W7GB
UT WOS:000806938300004
PM 35378101
DA 2025-06-11
ER

PT S
AU Chung, HS
   Choi, KM
AF Chung, Hye Soo
   Choi, Kyung Mook
BE Makowski, GS
TI Organokines in disease
SO ADVANCES IN CLINICAL CHEMISTRY, VOL 94
SE Advances in Clinical Chemistry
LA English
DT Review; Book Chapter
ID NONALCOHOLIC FATTY LIVER; GROWTH-FACTOR 21; ACTIVATED PROTEIN-KINASE;
   HIGH-DENSITY-LIPOPROTEIN; CORONARY-HEART-DISEASE; MOLECULAR-WEIGHT
   ADIPONECTIN; MESSENGER-RNA EXPRESSION; HUMAN SKELETAL-MUSCLE; PLASMA
   FETUIN-A; ALPHA(2)-HEREMANS-SCHMID GLYCOPROTEIN/FETUIN-A
AB Studies have linked obesity, metabolic syndrome, type 2 diabetes, cardiovascular disease (CVD), nonalcoholic fatty liver disease (NAFLD) and dementia. Their relationship to the incidence and progression of these disease states suggests an interconnected pathogenesis involving chronic low-grade inflammation and oxidative stress. Metabolic syndrome represents comorbidities of central obesity, insulin resistance, dyslipidemia, hypertension and hyperglycemia associated with increased risk of type 2 diabetes, NAFLD, atherosclerotic CVD and neurodegenerative disease. As the socioeconomic burden for these diseases has grown signficantly with an increasing elderly population, new and alternative pharmacologic solutions for these cardiometabolic diseases are required. Adipose tissue, skeletal muscle and liver are central endocrine organs that regulate inflammation, energy and metabolic homeostasis, and the neuroendocrine axis through synthesis and secretion of adipokines, myokines, and hepatokines, respectively. These organokines affect each other and communicate through various endocrine, paracrine and autocrine pathways. The ultimate goal of this review is to provide a comprehensive understanding of organ crosstalk. This will include the roles of novel organokines in normal physiologic regulation and their pathophysiological effect in obesity, metabolic syndrome, type 2 diabetes, CVD, NAFLD and neurodegenerative disorders.
C1 [Chung, Hye Soo] Hallym Univ, Coll Med, Dept Internal Med, Div Endocrinol & Metab, Seoul, South Korea.
   [Choi, Kyung Mook] Korea Univ, Coll Med, Dept Internal Med, Div Endocrinol & Metab, Seoul, South Korea.
C3 Hallym University; Korea University; Korea University Medicine (KU
   Medicine)
RP Choi, KM (corresponding author), Korea Univ, Coll Med, Dept Internal Med, Div Endocrinol & Metab, Seoul, South Korea.
EM medica7@gmail.com
RI Choi, Kyung/C-4195-2018; Chung, Hye/AAG-8591-2020
OI Choi, Kyung Mook/0000-0001-6175-0225
FU Korea University Research Fund [B1901301]
FX This work was supported by the Korea University Research Fund
   (B1901301).
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NR 406
TC 31
Z9 33
U1 0
U2 4
PU ACADEMIC PRESS LTD-ELSEVIER SCIENCE LTD
PI LONDON
PA 125 LONDON WALL, LONDON EC2Y 5AS, ENGLAND
SN 0065-2423
EI 2162-9471
BN 978-0-12-820801-4
J9 ADV CLIN CHEM
JI Advan. Clin. Chem.
PY 2020
VL 94
BP 261
EP 321
DI 10.1016/bs.acc.2019.07.012
PG 61
WC Medical Laboratory Technology
WE Book Citation Index – Science (BKCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA BQ5XH
UT WOS:000609196500007
PM 31952573
DA 2025-06-11
ER

PT J
AU Addison, S
   Stas, S
   Hayden, MR
   Sowers, JR
AF Addison, Sonya
   Stas, Sameer
   Hayden, Melvin R.
   Sowers, James R.
TI Insulin resistance and blood pressure
SO CURRENT HYPERTENSION REPORTS
LA English
DT Article
ID TYPE-2 DIABETES-MELLITUS; C-REACTIVE PROTEIN; METABOLIC SYNDROME;
   HYPERTENSIVE PATIENTS; RECEPTOR BLOCKERS; OXIDATIVE STRESS;
   ANGIOTENSIN-II; ALDOSTERONE; METOPROLOL; TRIAL
AB Insulin resistance, cardiometabolic syndrome, and hypertension are common health problems with significant consequences for individuals and society. The pathogenesis of these disorders is complex and not fully understood. In this article we review the current knowledge about the effects of lifestyle modification and pharmacologic antihypertensive agents on insulin resistance and hypertension.
C1 [Addison, Sonya; Stas, Sameer; Hayden, Melvin R.; Sowers, James R.] Univ Missouri, Sch Med, Diabet & Cardiovasc Ctr, Harry S Truman VA Med Ctr, Columbia, MO 65212 USA.
C3 US Department of Veterans Affairs; Veterans Health Administration (VHA);
   Harry S. Truman Memorial Veterans' Hospital; University of Missouri
   System; University of Missouri Columbia
RP Sowers, JR (corresponding author), Univ Missouri, Sch Med, Diabet & Cardiovasc Ctr, Harry S Truman VA Med Ctr, D109 HSC Diabet Ctr,1 Hosp Dr, Columbia, MO 65212 USA.
EM sowersj@health.missouri.edu
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NR 43
TC 19
Z9 22
U1 0
U2 2
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1522-6417
EI 1534-3111
J9 CURR HYPERTENS REP
JI Curr. Hypertens. Rep.
PD AUG
PY 2008
VL 10
IS 4
BP 319
EP 325
DI 10.1007/s11906-008-0059-1
PG 7
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 329EC
UT WOS:000257848700013
PM 18625163
DA 2025-06-11
ER

PT J
AU Karimi, E
   Dehghan, P
   Azizi-Soleiman, F
   Mohamadizadeh, M
AF Karimi, Elham
   Dehghan, Parvin
   Azizi-Soleiman, Fatemeh
   Mohamadizadeh, Mehdi
TI Date seed (phoenix dactylifera) supplementation modulates oxidative DNA
   damage, lipid peroxidation, and cardiometabolic risk factors in type 2
   diabetes: A triple-blinded randomized placebo-controlled trial
SO JOURNAL OF FUNCTIONAL FOODS
LA English
DT Article
DE Date seed; Inflammation; Oxidative stress; Polyphenol; Functional food;
   Type 2 diabetes; Prebiotic
ID CHAIN FATTY-ACIDS; APO-B; ANTIOXIDANT; EXTRACT; COMPLICATIONS; STRESS
AB We examined if the supplementation of date seed powder (DSP) could improve inflammation, oxidative stress, and cardiometabolic status in diabetic patients. Forty three patients, aged 30-50 y, were randomized to receive either 5 g/d maltodextrin (i.e., placebo) or 5 g/d DSP (i.e. intervention) for eight weeks. Total cholesterol (TC), triglyceride (TG), low- and high-density lipoprotein cholesterol (LDL-c and HDL-c), the Castelli I Index (i.e., TC/ HDL-c ratio), and Atherogenic index [Log (TG/HDL-c)], lipopolysaccharide (LPS), high-sensitivity C-reactive protein (hs-CRP), tumor necrosis factor-alpha (TNF-alpha), oxidative stress index (OSI), total oxidant status (TOS), malondialdehyde (MDA), 8-hydroxy-2 '-deoxyguanosine (8-OHdG), oxidized-LDL-c (ox-LDL-c), fasting plasma glucose (FPG), and glycated hemoglobin A1c (HbA1c) were measured at the baseline and end of the study. We used independent t-test and analysis of covariance (ANCOVA) for between-group comparisons at the baseline and the post-intervention phase, respectively. Between-group comparisons showed that supplementation with DSP significantly decreased HbA1c (-0.30%, p = 0.002), TC (-16.18 mg/dL, p = 0.001), TG (-21.27 mg/dL, p = 0.001), LDL-c (-13.41 mg/dL, p = 0.007), TC/HDL-c (-0.52, p = 0.001), LDL-c/HDL-c (-0.38, p = 0.003), Log (TG/HDL) (-0.06, p = 0.001), LPS (-3.67 EU/mL, p = 0.001), TNF-alpha (-3.69 ng/mL, p = 0.001), OSI (-5.01, p = 0.001), MDA (-0.25 nmol/mL, p = 0.010), 8-OHDG (-1.58 pg/mL, p = 0.002), and ox-LDL-c (-7.48 UL-1, p = 0.001). On the other hand, DSP supplementation significantly increased total antioxidant capacity (0.50 mmol/L, p = 0.001) compared to the placebo group. The two groups, however, were comparable regarding changes in FPG, HDL-c, VLDL-c, hs-CRP, and TOS. Overall, DSP seems to be an effective functional food for improving oxidative stress and cardiometabolic risk factors in diabetic patients. (Registration ID at https://www. irct.ir: IRCT20150205020965N10)
C1 [Karimi, Elham; Mohamadizadeh, Mehdi] Tabriz Univ Med Sci, Student Res Comm, Fac Nutr & Food Sci, Tabriz, Iran.
   [Dehghan, Parvin] Tabriz Univ Med Sci, Fac Nutr & Food Sci, Nutr Res Ctr, Dept Biochem & Diet Therapy, Tabriz, Iran.
   [Azizi-Soleiman, Fatemeh] Arak Univ Med Sci, Sch Hlth, Dept Nutr, Arak, Iran.
   [Dehghan, Parvin; Azizi-Soleiman, Fatemeh] Arak Univ Med Sci, Tabriz Univ Med Sci, Sch Hlth, Dept Nutr, Arak 3818146851, Iran.
C3 Tabriz University of Medical Science; Tabriz University of Medical
   Science; Tabriz University of Medical Science
RP Dehghan, P; Azizi-Soleiman, F (corresponding author), Arak Univ Med Sci, Tabriz Univ Med Sci, Sch Hlth, Dept Nutr, Arak 3818146851, Iran.
EM Dehghanp@tbzmed.ac.ir; azizi.s@arakmu.ac.ir;
   mohammadizadeh.m@tbzmed.ac.ir
RI Azizi-Soleiman, Fatemeh/W-1087-2019; dehghan, parvin/G-3885-2015;
   Karimi, Elham/AAW-7037-2020
FU Tabriz University of Medical Sciences [70183]
FX We express our gratitude to everyone who took part in the study. The
   Tabriz University of Medical Sciences provided funding for the research
   (grant number: 70183) .
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NR 64
TC 1
Z9 1
U1 1
U2 2
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1756-4646
EI 2214-9414
J9 J FUNCT FOODS
JI J. Funct. Food.
PD JUN
PY 2024
VL 117
AR 106226
DI 10.1016/j.jff.2024.106226
EA MAY 2024
PG 10
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA TQ0A4
UT WOS:001242595200001
OA gold
DA 2025-06-11
ER

PT J
AU Thomas, MS
   Huang, L
   Garcia, C
   Sakaki, JR
   Blesso, CN
   Chun, OK
   Fernandez, ML
AF Thomas, Minu S.
   Huang, Lindsey
   Garcia, Chelsea
   Sakaki, Junichi R.
   Blesso, Christopher N.
   Chun, Ock K.
   Fernandez, Maria Luz
TI The Effects of Eggs in a Plant-Based Diet on Oxidative Stress and
   Inflammation in Metabolic Syndrome
SO NUTRIENTS
LA English
DT Article
DE metabolic syndrome; eggs; plant-based diet; spinach; inflammation;
   oxidative stress
ID TOTAL ANTIOXIDANT CAPACITY; RISK; ASSOCIATION; MARKERS; VEGETARIANS;
   PROFILES; DISEASE; PROTEIN
AB We recently reported that the inclusion of whole eggs in plant-based diets (PBD) increased plasma choline, lutein, and zeaxanthin in individuals with metabolic syndrome (MetS). The objective of the current study was to evaluate whether this dietary pattern would protect against oxidative stress and low-grade inflammation, two common characteristics of MetS. We recruited 24 men and women with MetS, who, after following a PBD for 2 weeks (baseline), were randomly allocated to consume either two whole eggs with 70 g of spinach/day (EGG) or the equivalent amount of egg substitute with spinach (SUB) as breakfast for 4 weeks. After a 3-week washout, they were allocated to the alternate breakfast. We measured biomarkers of oxidation and inflammation at baseline and at the end of each intervention. Tumor necrosis factor-alpha, interleukin-6, monocyte protein attractant-1, liver enzymes, and C-reactive protein, as well as total antioxidant capacity, paraoxonase-1 (PON-1) activity, and other biomarkers of oxidation were not different at the end of EGG or SUB or when compared to baseline. However, plasma malondialdehyde (MDA) concentrations were lower (p < 0.05) during the EGG and baseline compared to SUB. In addition, the increases in dietary lutein and zeaxanthin previously observed had a strong positive correlation with PON-1 activity (r = 0.522, p < 0.01) only during the EGG period, whereas plasma zeaxanthin was negatively correlated with MDA (r = -0.437, p < 0.01). The number of participants with MetS was reduced from 24 during screening to 21, 13, and 17 during the BL, EGG, and SUB periods, respectively, indicating that eggs were more effective in reversing the characteristics of MetS. These data suggest that adding eggs to a PBD does not detrimentally affect inflammation or oxidative stress; on the contrary, eggs seem to provide additional protection against the biomarkers that define MetS.
C1 [Thomas, Minu S.; Huang, Lindsey; Garcia, Chelsea; Sakaki, Junichi R.; Blesso, Christopher N.; Chun, Ock K.; Fernandez, Maria Luz] Univ Connecticut, Dept Nutr Sci, Storrs, CT 06269 USA.
C3 University of Connecticut
RP Fernandez, ML (corresponding author), Univ Connecticut, Dept Nutr Sci, Storrs, CT 06269 USA.
EM minu.thomas@uconn.edu; lindsey.huang@uconn.edu;
   chelsea.garcia@uconn.edu; junichi.sakaki@uconn.edu;
   christopher.blesso@uconn.edu; ock.chun@uconn.edu;
   maria-luz.fernandez@uconn.edu
RI Blesso, Christopher/N-9495-2014; Thomas, Minu Sara/GOH-1463-2022
OI Blesso, Christopher/0000-0002-4434-4839; Garcia,
   Chelsea/0000-0002-7681-695X; Thomas, Minu Sara/0000-0002-1639-3086;
   Fernandez, Maria-Luz/0000-0002-1835-0792; Chun, Ock/0000-0002-7391-2380
FU Egg Nutrition Center, Chicago, IL, USA
FX This study was funded by the Egg Nutrition Center, Chicago, IL, USA.
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NR 46
TC 11
Z9 11
U1 0
U2 8
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JUN
PY 2022
VL 14
IS 12
AR 2548
DI 10.3390/nu14122548
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 2K2JU
UT WOS:000816169800001
PM 35745278
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Ravaut, G
   Légiot, A
   Bergeron, KF
   Mounier, C
AF Ravaut, Gaetan
   Legiot, Alexandre
   Bergeron, Karl-F.
   Mounier, Catherine
TI Monounsaturated Fatty Acids in Obesity-Related Inflammation
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE monounsaturated fatty acids (MUFA); stearoyl-CoA desaturase-1 (SCD1);
   chronic inflammation; saturated fatty acid (SFA); metabolic syndrome
ID ENDOPLASMIC-RETICULUM STRESS; NF-KAPPA-B; DEFICIENCY PROTECTS MICE; COA
   DESATURASE-1 GENE; C-REACTIVE PROTEIN; VIRGIN OLIVE OIL;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; MEDITERRANEAN DIET;
   ADIPOSE-TISSUE
AB Obesity is an important aspect of the metabolic syndrome and is often associated with chronic inflammation. In this context, inflammation of organs participating in energy homeostasis (such as liver, adipose tissue, muscle and pancreas) leads to the recruitment and activation of macrophages, which secrete pro-inflammatory cytokines. Interleukin-1 beta secretion, sustained C-reactive protein plasma levels and activation of the NLRP3 inflammasome characterize this inflammation. The Stearoyl-CoA desaturase-1 (SCD1) enzyme is a central regulator of lipid metabolism and fat storage. This enzyme catalyzes the generation of monounsaturated fatty acids (MUFAs)-major components of triglycerides stored in lipid droplets-from saturated fatty acid (SFA) substrates. In this review, we describe the molecular effects of specific classes of fatty acids (saturated and unsaturated) to better understand the impact of different diets (Western versus Mediterranean) on inflammation in a metabolic context. Given the beneficial effects of a MUFA-rich Mediterranean diet, we also present the most recent data on the role of SCD1 activity in the modulation of SFA-induced chronic inflammation.
C1 [Ravaut, Gaetan; Legiot, Alexandre; Bergeron, Karl-F.; Mounier, Catherine] Univ Quebec Montreal UQAM, Dept Biol Sci, Mol Metab Lipids Lab, CERMO FC Res Ctr, Montreal, PQ H3C 3P8, Canada.
C3 University of Quebec; University of Quebec Montreal
RP Mounier, C (corresponding author), Univ Quebec Montreal UQAM, Dept Biol Sci, Mol Metab Lipids Lab, CERMO FC Res Ctr, Montreal, PQ H3C 3P8, Canada.
EM ravaut.gaetan@courrier.uqam.ca; legiot.alexandre@courrier.uqam.ca;
   bergeron.karl-frederik@uqam.ca; mounier.catherine@uqam.ca
RI Mounier, Catherine/D-3690-2011
OI Ravaut, Gaetan/0000-0003-3309-3154; Bergeron,
   Karl-F./0000-0002-7215-9104
FU NSREC grant
FX G.R. was supported by the foundation Lueur d'espoir pour Ayden and A.L.
   by a NSREC grant.
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NR 193
TC 158
Z9 165
U1 10
U2 92
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD JAN
PY 2021
VL 22
IS 1
AR 330
DI 10.3390/ijms22010330
PG 22
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA PP9FC
UT WOS:000606158500001
PM 33396940
OA Green Accepted, gold, Green Published
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Iturriaga, R
   Del Rio, R
   Idiaquez, J
   Somers, VK
AF Iturriaga, Rodrigo
   Del Rio, Rodrigo
   Idiaquez, Juan
   Somers, Virend K.
TI Carotid body chemoreceptors, sympathetic neural activation, and
   cardiometabolic disease
SO BIOLOGICAL RESEARCH
LA English
DT Review
DE Autonomic dysfunction; Carotid body; Heart failure; Metabolic syndrome;
   Obstructive sleep apnea; Sympathetic activation
ID CHRONIC INTERMITTENT HYPOXIA; OBSTRUCTIVE SLEEP-APNEA; OXIDATIVE STRESS;
   HEART-FAILURE; BLOOD-PRESSURE; CARDIOVASCULAR-DISEASE; CARDIORESPIRATORY
   ALTERATIONS; CHEMOREFLEX SENSITIVITY; INFLAMMATORY CYTOKINES; AUTONOMIC
   CONTROL
AB The carotid body (CB) is the main peripheral chemoreceptor that senses the arterial PO2, PCO2 and pH. In response to hypoxemia, hypercapnia and acidosis, carotid chemosensory discharge elicits reflex respiratory, autonomic and cardiovascular adjustments. The classical construct considers the CB as the main peripheral oxygen sensor, triggering reflex physiological responses to acute hypoxemia and facilitating the ventilatory acclimation to chronic hypoxemia at high altitude. However, a growing body of experimental evidence supports the novel concept that an abnormally enhanced CB chemosensory input to the brainstem contributes to overactivation of the sympathetic nervous system, and consequent pathology. Indeed, the CB has been implicated in several diseases associated with increases in central sympathetic outflow. These include hypertension, heart failure, sleep apnea, chronic obstructive pulmonary disease and metabolic syndrome. Indeed, ablation of the CB has been proposed for the treatment of severe and resistant hypertension in humans. In this review, we will analyze and discuss new evidence supporting an important role for the CB chemoreceptor in the progression of autonomic and cardiorespiratory alterations induced by heart failure, obstructive sleep apnea, chronic obstructive pulmonary disease and metabolic syndrome.
C1 [Iturriaga, Rodrigo] Pontificia Univ Catolica Chile, Fac Ciencias Biol, Lab Neurobiol, Alameda 340, Santiago, Chile.
   [Del Rio, Rodrigo] Univ Autonoma Chile, Ctr Invest Biomed, Lab Cardioresp Control, Santiago, Chile.
   [Del Rio, Rodrigo] Univ Cient Sur, Direcc Invest, Lima, Peru.
   [Idiaquez, Juan] Univ Valparaiso, Catedra Neurol, Escuela Med, Valparaiso, Chile.
   [Somers, Virend K.] Mayo Clin, Div Cardiovasc Dis, Rochester, MN USA.
C3 Pontificia Universidad Catolica de Chile; Universidad Autonoma de Chile;
   Universidad Cientifica del Sur (CIENTIFICA); Universidad de Valparaiso;
   Mayo Clinic
RP Iturriaga, R (corresponding author), Pontificia Univ Catolica Chile, Fac Ciencias Biol, Lab Neurobiol, Alameda 340, Santiago, Chile.
EM riturriaga@bio.puc.cl
RI Iturriaga, Rodrigo/AAG-1020-2020; Del Rio, Rodrigo/AAF-8763-2020
OI Iturriaga, Rodrigo/0000-0001-5387-9897
FU FONDECYT [1150040, 1140275]; National Heart Lung and Blood Institute NIH
   [R01 HL65176]; NIH Roadmap for Medical Research
FX RI supported by FONDECYT 1150040, RDR by FONDECYT 1140275. VKS is
   supported by National Heart Lung and Blood Institute NIH R01 HL65176, a
   component of the National Institutes of Health (NIH) and the NIH Roadmap
   for Medical Research. Its contents are solely the responsibility of the
   authors and do not necessarily represent the official view of NCRR or
   NIH.
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NR 102
TC 72
Z9 77
U1 1
U2 31
PU SOC BIOLGIA CHILE
PI SANTIAGO
PA CASILLA 16164, SANTIAGO 9, CHILE
SN 0716-9760
EI 0717-6287
J9 BIOL RES
JI Biol. Res.
PD FEB 26
PY 2016
VL 49
AR 13
DI 10.1186/s40659-016-0073-8
PG 9
WC Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics
GA DF2VT
UT WOS:000371203200001
PM 26920146
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Chaldakov, GN
   Fiore, M
   Tonchev, AB
   Aloe, L
AF Chaldakov, G. N.
   Fiore, M.
   Tonchev, A. B.
   Aloe, L.
TI Adipopharmacology, a novel drug discovery approach: A metabotrophic
   perspective
SO LETTERS IN DRUG DESIGN & DISCOVERY
LA English
DT Article
DE adipobiology; BDNF; CNTF; metallothioneins; metabotrophins; NGF
ID NERVE GROWTH-FACTOR; ENDOPLASMIC-RETICULUM STRESS; NEUROTROPHIC FACTOR;
   METABOLIC SYNDROME; ADIPOSE-TISSUE; INSULIN-RESISTANCE; SIGNALING
   PATHWAY; GENE-EXPRESSION; PC12 CELLS; IN-VITRO
AB "Adipopharmacology" connotes the adipotargeting studies aimed at drug discovery. Here we focus on adipopharmacology of nerve growth factor, brain-derived neurotrophic factor, ciliary neurotrophic factor and metallothioneins. Because these factors improve glucose, lipid and antioxidant metabolism, we named them metabotrophic factors (metabotrophins).
C1 Med Univ, Div Cell Biol, BG-9002 Varna, Bulgaria.
   CNR, European Brain Res Inst, Inst Neurobiol & Mol Med, NGF Sect, I-00143 Rome, Italy.
C3 Medical University Varna; Consiglio Nazionale delle Ricerche (CNR)
RP Chaldakov, GN (corresponding author), Med Univ, Div Cell Biol, BG-9002 Varna, Bulgaria.
EM chaldakov@yahoo.com
RI Fiore, Marco/GLT-0780-2022; Tonchev, Anton/LKK-5568-2024
OI fiore, marco/0000-0001-6806-9715
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NR 58
TC 9
Z9 9
U1 0
U2 1
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1570-1808
EI 1875-628X
J9 LETT DRUG DES DISCOV
JI Lett. Drug Des. Discov.
PD SEP
PY 2006
VL 3
IS 7
BP 503
EP 505
DI 10.2174/157018006778194835
PG 3
WC Chemistry, Medicinal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 081GD
UT WOS:000240304300009
DA 2025-06-11
ER

PT J
AU Sabanovic, S
   Ljiljana, MT
   Babic, F
   Vadovsky, M
   Paralic, J
   Vcev, A
   Holzinger, A
AF Sabanovic, Sefket
   Ljiljana, Majnaric Trtica
   Babic, Frantisek
   Vadovsky, Michal
   Paralic, Jan
   Vcev, Aleksandar
   Holzinger, Andreas
TI Metabolic syndrome in hypertensive women in the age of menopause: a case
   study on data from general practice electronic health records
SO BMC MEDICAL INFORMATICS AND DECISION MAKING
LA English
DT Article
DE General practice; Research; Routine data; Electronic health records;
   Computer methods for data anlysis; Menopausal women; Hypertension;
   Metabolic syndrome
ID CARDIOVASCULAR-DISEASE; PRIMARY-CARE; GENDER-DIFFERENCES; RESEARCH
   NETWORKS; MIDLIFE WOMEN; ASSOCIATION; TRANSITION; OVERWEIGHT;
   DIFFERENCE; MANAGEMENT
AB Background: There is potential for medical research on the basis of routine data used from general practice electronic health records (GP eHRs), even in areas where there is no common GP research platform. We present a case study on menopausal women with hypertension and metabolic syndrome (MS). The aims were to explore the appropriateness of the standard definition of MS to apply to this specific, narrowly defined population group and to improve recognition of women at high CV risk.
   Methods: We investigated the possible uses offered by available data from GP eHRs, completed with patients interview, in goal of the study, using a combination of methods. For the sample of 202 hypertensive women, 47-59 years old, a data set was performed, consisted of a total number of 62 parameters, 50 parameters used from GP eHRs. It was analysed by using a mixture of methods: analysis of differences, cutoff values, graphical presentations, logistic regression and decision trees.
   Results: The age range found to best match the emergency of MS was 51-55 years. Deviations from the definition of MS were identified: a larger cut-off value of the waist circumference measure (89 vs 80 cm) and parameters BMI and total serum cholesterol perform better as components of MS than the standard parameters waist circumference and HDL-cholesterol. The threshold value of BMI at which it is expected that most of hypertensive menopausal women have MS, was found to be 25.5. The other best means for recognision of women with MS include triglycerides above the threshold of 1.7 mmol/L and information on statins use. Prevention of CVD should focus on women with a new onset diabetes and comorbidities of a long-term hypertension with anxiety/depression.
   Conclusions: The added value of this study goes beyond the current paradigm on MS. Results indicate characteristics of MS in a narrowly defined, specific population group. A comprehensive view has been enabled by using heterogenoeus data and a smart combination of various methods for data analysis. The paper shows the feasibility of this research approach in routine practice, to make use of data which would otherwise not be used for research.
C1 [Sabanovic, Sefket; Ljiljana, Majnaric Trtica; Vcev, Aleksandar] Josip Juraj Strossmayer Univ, Fac Med, Dept Internal Med Family Med & Hist Med, Huttlerova 10b, Osijek 31000, Croatia.
   [Babic, Frantisek; Vadovsky, Michal; Paralic, Jan] Tech Univ Kosice, Fac Elect Engn & Informat, Dept Cybernet & Artificial Intelligence, Letna 9-B, Kosice 04200, Slovakia.
   [Holzinger, Andreas] Med Univ Graz, Inst Med Informat Stat, Auenbruggerpl 2-5, A-8036 Graz, Austria.
C3 University of JJ Strossmayer Osijek; Technical University Kosice;
   Medical University of Graz
RP Holzinger, A (corresponding author), Med Univ Graz, Inst Med Informat Stat, Auenbruggerpl 2-5, A-8036 Graz, Austria.
EM andreas.holzinger@medunigraz.at
RI Babic, Frantisek/I-3890-2014; MAJNARIĆ, LJILJANA/JCO-5151-2023;
   HOLZINGER, Andreas/E-9530-2010; Paralic, Jan/H-5393-2013
OI HOLZINGER, Andreas/0000-0002-6786-5194; Babic,
   Frantisek/0000-0003-2225-5955; Paralic, Jan/0000-0002-4603-0411
FU Slovak Grant Agency of the Ministry of Education; Academy of Science of
   the Slovak Republic [1/0493/16]; Slovak Research and Development Agency
   [APVV-16-0213]
FX This work is approved by the University of Osijek Common Fund, through
   cooperative agreements. The views presented here are solely the
   responsibility of the authors and do not represent the official views of
   the Faculty of Medicine and the University of Osijek. The work was
   partially supported by the Slovak Grant Agency of the Ministry of
   Education and Academy of Science of the Slovak Republic under grant no.
   1/0493/16 and The Slovak Research and Development Agency under grant no.
   APVV-16-0213.
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NR 83
TC 10
Z9 10
U1 1
U2 7
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1472-6947
J9 BMC MED INFORM DECIS
JI BMC Med. Inform. Decis. Mak.
PD APR 2
PY 2018
VL 18
AR 24
DI 10.1186/s12911-018-0601-2
PG 18
WC Medical Informatics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Medical Informatics
GA GB2YU
UT WOS:000428922800001
PM 29609615
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Sylvia, LG
   Ametrano, RM
   Nierenberg, AA
AF Sylvia, Louisa G.
   Ametrano, Rebecca M.
   Nierenberg, Andrew A.
TI Exercise Treatment for Bipolar Disorder: Potential Mechanisms of Action
   Mediated through Increased Neurogenesis and Decreased Allostatic Load
SO PSYCHOTHERAPY AND PSYCHOSOMATICS
LA English
DT Review
DE Exercise; Brain-derived neurotrophic factor; Allostatic load; Bipolar
   disorder
ID NEUROTROPHIC FACTOR BDNF; LITHIUM-TREATED PATIENTS; MAJOR DEPRESSION;
   METABOLIC SYNDROME; PHYSICAL-ACTIVITY; VAL66MET POLYMORPHISM;
   SYNAPTIC-PLASTICITY; UNIPOLAR DEPRESSION; RAT HIPPOCAMPUS; LIFE EVENTS
AB Outcomes are frequently suboptimal for patients with bipolar disorder who are treated with pharmacotherapy alone. Adjunct exercise has the potential to substantially improve acute and long-term outcomes, although how exercise would improve the course of bipolar disorder needs to be elucidated. We propose that exercise may improve mood and functioning by increasing neurogenesis and reducing allostatic load. We review data suggesting that exercise increases levels of brain-derived neurotrophic factor, which in turn increases neurogenesis and decreases allostatic load. Exercise as a psychosocial adjunct for bipolar disorder should be assessed with rigorous randomized clinical trials. Copyright (C) 2009 S. Karger AG, Basel
C1 [Sylvia, Louisa G.; Ametrano, Rebecca M.; Nierenberg, Andrew A.] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Boston, MA USA.
C3 Harvard University; Harvard University Medical Affiliates; Massachusetts
   General Hospital; Harvard Medical School
RP Sylvia, LG (corresponding author), 50 Staniford St,Suite 580, Boston, MA 02114 USA.
EM lsylvia2@partners.org
RI Sylvia, Louisa/AAE-8027-2022; Nierenberg, ANierenberg/IAR-5549-2023
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NR 124
TC 48
Z9 49
U1 0
U2 30
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0033-3190
EI 1423-0348
J9 PSYCHOTHER PSYCHOSOM
JI Psychother. Psychosom.
PY 2010
VL 79
IS 2
BP 87
EP 96
DI 10.1159/000270916
PG 10
WC Psychiatry; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry; Psychology
GA 555PW
UT WOS:000274526600003
PM 20051706
DA 2025-06-11
ER

PT J
AU Gambino, G
   Giglia, G
   Allegra, M
   Di Liberto, V
   Zummo, FP
   Rappa, F
   Restivo, I
   Vetrano, F
   Saiano, F
   Palazzolo, E
   Avellone, G
   Ferraro, G
   Sardo, P
   Di Majo, D
AF Gambino, Giuditta
   Giglia, Giuseppe
   Allegra, Mario
   Di Liberto, Valentina
   Zummo, Francesco Paolo
   Rappa, Francesca
   Restivo, Ignazio
   Vetrano, Filippo
   Saiano, Filippo
   Palazzolo, Eristanna
   Avellone, Giuseppe
   Ferraro, Giuseppe
   Sardo, Pierangelo
   Di Majo, Danila
TI "Golden" Tomato Consumption Ameliorates Metabolic Syndrome: A Focus on
   the Redox Balance in the High-Fat-Diet-Fed Rat
SO ANTIOXIDANTS
LA English
DT Article
DE tomato-based products; metabolic syndrome; HFD; antioxidant capacity;
   phytonutrients
ID OXIDATIVE STRESS LEVELS; SUPPLEMENTATION; NARINGENIN; LIVER; RISK;
   DEFINITION; EXPRESSION; MICROBIOTA; OBESITY; LIPIDS
AB Tomato fruits defined as "golden" refer to a food product harvested at an incomplete ripening stage with respect to red tomatoes at full maturation. The aim of this study is to explore the putative influence of "golden tomato" (GT) on Metabolic Syndrome (MetS), especially focusing on the effects on redox homeostasis. Firstly, the differential chemical properties of the GT food matrix were characterized in terms of phytonutrient composition and antioxidant capacities with respect to red tomato (RT). Later, we assessed the biochemical, nutraceutical and eventually disease-modifying potential of GT in vivo in the high-fat-diet rat model of MetS. Our data revealed that GT oral supplementation is able to counterbalance MetS-induced biometric and metabolic modifications. Noteworthy is that this nutritional supplementation proved to reduce plasma oxidant status and improve the endogenous antioxidant barriers, assessed by strong systemic biomarkers. Furthermore, consistently with the reduction of hepatic reactive oxygen and nitrogen species (RONS) levels, treatment with GT markedly reduced the HFD-induced increase in hepatic lipid peroxidation and hepatic steatosis. This research elucidates the importance of food supplementation with GT in the prevention and management of MetS.
C1 [Gambino, Giuditta; Giglia, Giuseppe; Di Liberto, Valentina; Zummo, Francesco Paolo; Rappa, Francesca; Ferraro, Giuseppe; Sardo, Pierangelo; Di Majo, Danila] Univ Palermo, Dept Biomed Neurosci & Adv Diagnost BIND, I-90127 Palermo, Italy.
   [Giglia, Giuseppe] Euro Mediterranean Inst Sci & Technol IEMEST, I-90139 Palermo, Italy.
   [Allegra, Mario; Ferraro, Giuseppe; Sardo, Pierangelo; Di Majo, Danila] Univ Palermo, Postgrad Sch Nutr & Food Sci, I-90100 Palermo, Italy.
   [Allegra, Mario; Restivo, Ignazio; Avellone, Giuseppe] Univ Palermo, Dept Biol Chem & Pharmaceut Sci & Technol STEBICEF, Viale Sci, I-90128 Palermo, Italy.
   [Vetrano, Filippo; Saiano, Filippo; Palazzolo, Eristanna] Univ Palermo, Dipartimento Sci Agrarie Alimentari & Forestali, Viale Sci Ed4, I-90128 Palermo, Italy.
   [Avellone, Giuseppe] ATeN Adv Technol Network Ctr, Viale Sci, I-90128 Palermo, Italy.
C3 University of Palermo; University of Palermo; University of Palermo;
   University of Palermo
RP Gambino, G (corresponding author), Univ Palermo, Dept Biomed Neurosci & Adv Diagnost BIND, I-90127 Palermo, Italy.
EM giuditta.gambino@unipa.it; giuseppe.giglia@unipa.it;
   mario.allegra@unipa.it; valentina.diliberto@unipa.it;
   francescopaolo.zummo@unipa.it; francesca.rappa@unipa.it;
   filippo.vetrano@unipa.it; filippo.saiano@unipa.it;
   eristanna.palazzolo@unipa.it; giuseppe.avellone@unipa.it;
   giuseppe.ferraro@unipa.it; pierangelo.sardo@unipa.it;
   danila.dimajo@unipa.it
RI Restivo, Ignazio/AAW-8282-2020; Francesca, Rappa/ADW-8431-2022;
   Avellone, Giuseppe/Q-2826-2016; Di Majo, Danila/A-9078-2015; Di+Liberto,
   Valentina/ACL-0264-2022; Zummo, Francesco Paolo/HME-2405-2023; Allegra,
   Mario/AAG-3256-2019; Giglia, Giuseppe/M-7100-2016
OI DI MAJO, Danila/0000-0002-0533-6932; Gambino,
   Giuditta/0000-0001-8155-2808; rappa, francesca/0000-0001-6610-5268;
   Saiano, Filippo/0000-0001-6873-3698; RESTIVO,
   IGNAZIO/0000-0003-1833-2356; Zummo, Francesco Paolo/0000-0001-9872-8574;
   Di Liberto, Valentina/0000-0002-8574-0061; Allegra,
   Mario/0000-0002-5846-1868; Giglia, Giuseppe/0000-0001-5616-3595
FU PSR Sicilia [G66D20000170009]; University of Palermo
FX This work was partly supported by the project IN.PO.S.A-Grant Number:
   G66D20000170009, funded by PSR Sicilia (2014-2020)-16.1 and partly with
   FFR Funds provided by University of Palermo to Danila Di Majo and
   Giuditta Gambino.
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NR 73
TC 6
Z9 6
U1 0
U2 1
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD MAY 18
PY 2023
VL 12
IS 5
AR 1121
DI 10.3390/antiox12051121
PG 20
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA H2ZW5
UT WOS:000994711100001
PM 37237987
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Kushiyama, A
   Nakatsu, Y
   Matsunaga, Y
   Yamamotoya, T
   Mori, K
   Ueda, K
   Inoue, Y
   Sakoda, H
   Fujishiro, M
   Ono, H
   Asano, T
AF Kushiyama, Akifumi
   Nakatsu, Yusuke
   Matsunaga, Yasuka
   Yamamotoya, Takeshi
   Mori, Keiichi
   Ueda, Koji
   Inoue, Yuki
   Sakoda, Hideyuki
   Fujishiro, Midori
   Ono, Hiraku
   Asano, Tomoichiro
TI Role of Uric Acid Metabolism-Related Inflammation in the Pathogenesis of
   Metabolic Syndrome Components Such as Atherosclerosis and Nonalcoholic
   Steatohepatitis
SO MEDIATORS OF INFLAMMATION
LA English
DT Review
ID FATTY LIVER-DISEASE; IMPROVES ENDOTHELIAL FUNCTION; XANTHINE-OXIDASE
   INHIBITION; MUSCLE-CELL-PROLIFERATION; HIGH-DOSE ALLOPURINOL; OXIDATIVE
   STRESS; BLOOD-PRESSURE; CARDIOVASCULAR-DISEASE; ESSENTIAL-HYPERTENSION;
   ISCHEMIA-REPERFUSION
AB Uric acid (UA) is the end product of purine metabolism and can reportedly act as an antioxidant. However, recently, numerous clinical and basic research approaches have revealed close associations of hyperuricemia with several disorders, particularly those comprising the metabolic syndrome. In this review, we first outline the two molecular mechanisms underlying inflammation occurrence in relation to UA metabolism; one is inflammasome activation by UA crystallization and the other involves superoxide free radicals generated by xanthine oxidase (XO). Importantly, recent studies have demonstrated the therapeutic or preventive effects of XO inhibitors against atherosclerosis and nonalcoholic steatohepatitis, which were not previously considered to be related, at least not directly, to hyperuricemia. Such beneficial effects of XO inhibitors have been reported for other organs including the kidneys and the heart. Thus, a major portion of this review focuses on the relationships between UA metabolism and the development of atherosclerosis, nonalcoholic steatohepatitis, and related disorders. Although further studies are necessary, XO inhibitors are a potentially novel strategy for reducing the risk of many forms of organ failure characteristic of the metabolic syndrome.
C1 [Kushiyama, Akifumi] Asahi Life Fdn, Inst Adult Dis, Div Diabet & Metab, Chiyoda Ku, 1-6-1 Marunouchi, Tokyo, Japan.
   [Nakatsu, Yusuke; Matsunaga, Yasuka; Yamamotoya, Takeshi; Mori, Keiichi; Ueda, Koji; Inoue, Yuki; Asano, Tomoichiro] Hiroshima Univ, Grad Sch Med, Dept Med Sci, Minami Ku, 1-2-3 Kasumi, Hiroshima, Hiroshima, Japan.
   [Sakoda, Hideyuki] Miyazaki Univ, Dept Internal Med, Fac Med, Div Neurol Respirol Endocrinol & Metab, Miyazaki 8891692, Japan.
   [Fujishiro, Midori] Univ Tokyo, Grad Sch Med, Dept Internal Med, Bunkyo Ku, 7-3-1 Hongo, Tokyo, Japan.
   [Ono, Hiraku] Saitama Med Univ, Sch Med, Dept Endocrinol & Diabet, Moroyama, Saitama 3500495, Japan.
C3 Asahi Life Foundation; Hiroshima University; University of Miyazaki;
   University of Tokyo; Saitama Medical University
RP Kushiyama, A (corresponding author), Asahi Life Fdn, Inst Adult Dis, Div Diabet & Metab, Chiyoda Ku, 1-6-1 Marunouchi, Tokyo, Japan.
EM kusiyaa-tky@umin.ac.jp
RI 祐介, 中津/AAP-8396-2020; Kushiyama, Akifumi/W-5988-2019
OI Nakatsu, Yusuke/0000-0003-3279-1276; Kushiyama,
   Akifumi/0000-0003-1385-7487
FU Grants-in-Aid for Scientific Research [15K09398, 16J09463] Funding
   Source: KAKEN
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NR 180
TC 117
Z9 120
U1 0
U2 21
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 0962-9351
EI 1466-1861
J9 MEDIAT INFLAMM
JI Mediat. Inflamm.
PY 2016
VL 2016
AR 8603164
DI 10.1155/2016/8603164
PG 15
WC Cell Biology; Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Immunology
GA EG1JU
UT WOS:000390789200001
PM 28070145
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Lim, HJ
   Seo, MS
   Shim, JY
   Kim, KE
   Shin, YH
   Lee, YJ
AF Lim, Hyoung-Ji
   Seo, Min-Seok
   Shim, Jae-Yong
   Kim, Kyu-Earn
   Shin, Youn Ho
   Lee, Yong-Jae
TI The association between platelet count and metabolic syndrome in
   children and adolescents
SO PLATELETS
LA English
DT Article
DE Adolescents; children; inflammation; metabolic syndrome; platelet count
ID INSULIN-RESISTANCE; HEMATOLOGICAL PARAMETERS; DIABETES-MELLITUS;
   OXIDATIVE STRESS; YOUNG ADULTHOOD; THROMBOPOIETIN; COMPONENTS;
   CHILDHOOD; DISEASE; GIRLS
AB The goal of this study was to evaluate the association between platelet count and metabolic syndrome (MetS) in children and adolescents in Korea. This study included data from 2228 subjects (1201 boys and 1027 girls) who participated in the 2010-2012 Korean National Health and Nutrition Examination Survey (KNHANES-V). We used the modified National Cholesterol Education Program-Adult Treatment Panel III (NCEP-ATP III) criteria to define MetS. Odds ratios (95% confidence intervals [CIs]) for MetS were calculated with a multiple logistic regression analysis after adjusting for confounding factors across platelet count quartiles. The overall prevalence of MetS according to the modified NCEP-ATP III criteria was 4.9% (+/- 0.7%) in boys and 5.7% (+/- 0.9%) in girls. The prevalence of MetS significantly increased with increasing platelet quartiles in both boys and girls. In a multiple logistic regression analysis, the adjusted ORs (95% CIs) for the highest vs. the lowest quartile were 5.03 (1.30-19.48) in boys and 4.08 (1.20-13.93) in girls after adjusting for age and total cholesterol. Conclusions: Higher platelet count was associated with increased prevalence and risk of MetS in children and adolescents.
C1 [Lim, Hyoung-Ji; Seo, Min-Seok; Shim, Jae-Yong; Lee, Yong-Jae] Yonsei Univ, Coll Med, Dept Family Med, Gangnam Severance Hosp, Seoul 135720, South Korea.
   [Seo, Min-Seok] Yonsei Univ, Grad Sch Med, Dept Med, Seoul 135720, South Korea.
   [Kim, Kyu-Earn] Yonsei Univ, Gangnam Severance Hosp, Dept Pediat, Coll Med, Seoul 135720, South Korea.
   [Shin, Youn Ho] CHA Univ, Sch Med, Dept Pediat, Seoul, South Korea.
C3 Yonsei University; Yonsei University Health System; Yonsei University;
   Yonsei University; Yonsei University Health System; Pochon Cha
   University
RP Lee, YJ (corresponding author), Yonsei Univ, Coll Med, Dept Family Med, 211 Eonju Ro, Seoul 135720, South Korea.
EM ukyjhome@yuhs.ac
RI Seo, Minseok/JXM-0791-2024; Kim, Seong-Jun/KIJ-2249-2024; Lee, Yong
   Jae/GLR-4153-2022; Patthipati, Venkata Suresh/AAT-8233-2021; Shim, Jae
   Yong/GLU-2862-2022
OI Lee, Yong-Jae/0000-0002-6697-476X; Shim, JaeYong/0000-0002-9561-9230;
   Seo, Minseok/0000-0001-5551-4891
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NR 26
TC 19
Z9 19
U1 0
U2 9
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 0953-7104
EI 1369-1635
J9 PLATELETS
JI Platelets
PY 2015
VL 26
IS 8
BP 758
EP 763
DI 10.3109/09537104.2014.995613
PG 6
WC Cell Biology; Hematology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Hematology
GA DD4KT
UT WOS:000369892400008
PM 25549052
DA 2025-06-11
ER

PT J
AU Mosca, L
   Edelman, D
   Mochari, H
   Christian, AH
   Paultre, F
   Pollin, I
AF Mosca, L
   Edelman, D
   Mochari, H
   Christian, AH
   Paultre, F
   Pollin, I
TI Waist circumference predicts cardiometabolic and global Framingham risk
   among women screened during national woman's heart day
SO JOURNAL OF WOMENS HEALTH
LA English
DT Article
ID ACUTE MYOCARDIAL-INFARCTION; DISEASE RISK; ASSOCIATION; DEPRESSION;
   CHOLESTEROL; DIAGNOSIS; AWARENESS; OBESITY
AB Purpose: To evaluate the cardiometabolic risk profiles of 6938 women (mean age 49.2 +/- 14.6 years) attending the 2005 Sister to Sister: Everyone Has a Heart Foundation free public health standardized cardiovascular disease (CVD) risk factor screening events in 12 cities across the United States by race/ethnicity and waist circumference.
   Main findings: Among women without a history of CVD or diabetes (n = 6327), 90% were found to have at least one major modifiable CVD risk factor, with one-third of women having three or more major risk factors. Nearly half of all women with elevated total cholesterol (>= 200 mg/dL) or low high-density lipoprotein (HDL)-cholesterol (< 50 mg/dL) did not report a known history of abnormal cholesterol. Among women with no history of hypertension, 16% had a blood pressure >= 140/90 mm Hg. Unrecognized diabetes and glucose intolerance were striking among fasting women (n = 1218; 9% had a blood glucose >= 126 mg/dL and 43% had a blood glucose >= 100 mg/dL). In adjusted logistic regression models, women with a waist circumference >= 35 inches were more likely to have blood pressure >= 140/90 (OR = 1.9, p < 0.0001), total cholesterol >= 200 mg/dL (OR = 1.2, p = 0.006), HDL-cholesterol < 50 mg/dL (OR = 2.5, p < 0.0001), fasting glucose >= 100 mg/dL (OR = 2.0, p < 0.0001), and Framingham global risk score >= 10%, CVD or diabetes (OR = 2.0, p < 0.0001). Waist circumference was significantly correlated with Framingham global risk (r = 0.24, p < 0.001) and number of risk factors (r = 0.24, p < 0.0001). Increased clustering of risk factors was predictive of waist size >= 35 inches vs. < 35 inches in logistic models (p for trend > 0.0001). Among a subsample of women who underwent standardized screening for stress and depression, 62% had stress levels associated with increased cardiac risk, and 27% met criteria for clinical depression.
   Conclusions: Hypertension, dyslipidemia, and/or impaired fasting glucose were newly identified in approximately half the women screened. Waist size significantly correlated with clustering of risk factors, global Framingham risk score, CVD and diabetes, suggesting it may be an easily measured surrogate for women at increased risk of future cardiovascular clinical events who may benefit from further assessment and intervention.
C1 Columbia Univ, Med Ctr, New York State Psychiat Inst & Hosp, New York, NY 10032 USA.
C3 New York State Psychiatry Institute; Columbia University
RP Columbia Univ, Med Ctr, New York State Psychiat Inst & Hosp, 622 W 16th St,PH 10-203B, New York, NY 10032 USA.
EM ljm10@columbia.edu
OI Greenberger, Heidi Mochari/0000-0003-3334-0119
CR [Anonymous], DIABETES CARE S1
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NR 29
TC 15
Z9 20
U1 0
U2 1
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-9996
EI 1931-843X
J9 J WOMENS HEALTH
JI J. Womens Health
PD JAN
PY 2006
VL 15
IS 1
BP 24
EP 34
DI 10.1089/jwh.2006.15.24
PG 11
WC Public, Environmental & Occupational Health; Medicine, General &
   Internal; Obstetrics & Gynecology; Women's Studies
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; General & Internal
   Medicine; Obstetrics & Gynecology; Women's Studies
GA 007RY
UT WOS:000234988500005
PM 16417415
DA 2025-06-11
ER

PT J
AU Kim, YH
   Kim, JJ
   Kim, SM
   Choi, Y
   Jeon, MJ
AF Kim, Yun Hwan
   Kim, Jin Ju
   Kim, Sun Mie
   Choi, Yunhee
   Jeon, Myung Jae
TI Association between metabolic syndrome and pelvic floor dysfunction in
   middle-aged to older Korean women
SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
LA English
DT Article
DE metabolic syndrome; pelvic floor distress inventory (PFDI); pelvic floor
   dysfunction
ID URINARY-TRACT SYMPTOMS; DIABETES-MELLITUS; NATIONAL-HEALTH;
   RISK-FACTORS; DISORDERS; OBESITY; INCONTINENCE; PREVALENCE; BLADDER;
   STRESS
AB OBJECTIVE: The purpose of this study was to evaluate the association of metabolic syndrome (MS) with female pelvic floor dysfunction in middle-aged to older Korean women.
   STUDY DESIGN: A prospective cross-sectional study was performed that included a total of 984 Korean women (>= 40 years old) who visited a comprehensive medical screening clinic. Pelvic floor dysfunction was assessed by the Pelvic Floor Distress Inventory-20 (PFDI-20); higher scores indicated a greater symptom burden.
   RESULTS: The adjusted mean score on the PFDI-20, and especially the Urinary Distress Inventory-6 subscale, was significantly higher in subjects with MS than those without MS. Furthermore, the PFDI-20 and all 3 subscales were significantly increased in correlation with the number of MS components that were present (P < .05). In the multivariable analysis, MS was associated significantly with PFDI-20 (P = .002) and the 3 subscores (P < .05).
   CONCLUSION: MS was significantly associated with the pelvic floor dysfunction among middle-to old-aged Korean women. Physicians should pay more attention to the pelvic floor symptoms for the patients with MS.
C1 [Jeon, Myung Jae] Seoul Natl Univ, Coll Med, Dept Obstet & Gynecol, Seoul 110744, South Korea.
   [Kim, Yun Hwan] Ewha Womans Univ, Dept Obstet & Gynecol, Sch Med, Seoul, South Korea.
   [Kim, Yun Hwan] Ewha Womans Univ, Med Res Inst, Sch Med, Seoul, South Korea.
   [Kim, Jin Ju; Kim, Sun Mie] Seoul Natl Univ Hosp Hlth Care Syst, GangNam Ctr, Dept Obstet & Gynecol, Seoul, South Korea.
   [Choi, Yunhee] Seoul Natl Univ Hosp, Med Res Collaborating Ctr, Seoul 110744, South Korea.
C3 Seoul National University (SNU); Ewha Womans University; Ewha Womans
   University; Seoul National University (SNU); Seoul National University
   Hospital; Seoul National University (SNU); Seoul National University
   Hospital
RP Jeon, MJ (corresponding author), Seoul Natl Univ, Coll Med, Dept Obstet & Gynecol, 28 Yongon Dong, Seoul 110744, South Korea.
EM jeonmj@snu.ac.kr
RI Choi, You-Jung/AFR-4193-2022; Kim, Jin/C-4294-2013; Kim, Kwang
   Pyo/AAG-1815-2020; Jeon, Myung/O-2486-2019
OI Kim, Yun Hwan/0000-0001-9498-2938; Jeon, Myung Jae/0000-0001-5582-1488
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NR 30
TC 12
Z9 12
U1 1
U2 5
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0002-9378
EI 1097-6868
J9 AM J OBSTET GYNECOL
JI Am. J. Obstet. Gynecol.
PD JUL
PY 2011
VL 205
IS 1
AR 71.e1
DI 10.1016/j.ajog.2011.02.047
PG 8
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA 783KX
UT WOS:000292082400038
PM 21481837
DA 2025-06-11
ER

PT J
AU Szydlarska, J
   Weiss, C
   Marycz, K
AF Szydlarska, Joanna
   Weiss, Christine
   Marycz, Krzysztof
TI The Effect of Methyl-β-cyclodextrin on Apoptosis, Proliferative
   Activity, and Oxidative Stress in Adipose-Derived Mesenchymal Stromal
   Cells of Horses Suffering from Metabolic Syndrome (EMS)
SO MOLECULES
LA English
DT Article
DE equine metabolic syndrome; mesenchymal stem cells;
   methyl-beta-cyclodextrin; cyclodextrin; stem cells
ID MEMBRANE CHOLESTEROL; GLUCOSE-TRANSPORT; INSULIN-SECRETION; LIPID RAFTS;
   STEM-CELLS; GLUT4; ADIPOCYTES; DISEASE; OBESITY; TRANSLOCATION
AB Methyl-beta-cyclodextrin (M beta CD) is a cyclic oligosaccharide, commonly used as a pharmacological agent to deplete membrane cholesterol. In this study, we examined the effect of M beta CD on adipose-derived mesenchymal stromal cells (ASCs) isolated form healthy horses (ASC(CTRL)) and from horses suffering from metabolic syndrome (ASC(EMS)). We investigated the changes in the mRNA levels of the glucose transporter 4 (GLUT4) and found that M beta CD application may lead to a significant improvement in glucose transport in ASC(EMS). We also showed that M beta CD treatment affected GLUT4 upregulation in an insulin-independent manner via an NO-dependent signaling pathway. Furthermore, the analysis of superoxide dismutase activity (SOD) and reactive oxygen species (ROS) levels showed that M beta CD treatment was associated with an increased antioxidant capacity in ASC(EMS). Moreover, we indicated that methyl-beta-cyclodextrin treatment did not cause a dysfunction of the endoplasmic reticulum and lysosomes. Thereby, we propose the possibility of improving the functionality of ASC(EMS) by increasing their metabolic stability.
C1 [Szydlarska, Joanna; Weiss, Christine; Marycz, Krzysztof] Wroclaw Univ Environm & Life Sci, Fac Biol & Anim Sci, Dept Expt Biol, PL-50631 Wroclaw, Poland.
   [Szydlarska, Joanna; Weiss, Christine; Marycz, Krzysztof] Wroclaw Univ Environm & Life Sci, Fac Biol & Anim Sci, Electron Microscope Facil, PL-50631 Wroclaw, Poland.
   [Marycz, Krzysztof] Wroclaw Res Ctr EIT, PL-54066 Wroclaw, Poland.
C3 Wroclaw University of Environmental & Life Sciences; Wroclaw University
   of Environmental & Life Sciences
RP Marycz, K (corresponding author), Wroclaw Univ Environm & Life Sci, Fac Biol & Anim Sci, Dept Expt Biol, PL-50631 Wroclaw, Poland.; Marycz, K (corresponding author), Wroclaw Univ Environm & Life Sci, Fac Biol & Anim Sci, Electron Microscope Facil, PL-50631 Wroclaw, Poland.; Marycz, K (corresponding author), Wroclaw Res Ctr EIT, PL-54066 Wroclaw, Poland.
EM joanna.szydlarska@gmail.com; d.weiss@horsedoc.ch;
   krzysztofmarycz@interia.pl
FU Ministry of Science and Higher Education, Poland [DI2016/009246];
   Leading National Research Centre (KNOW, Krajowy Naukowy Osrodek Wiodacy)
   program
FX The authors thank Jakub Grzesiak for performing the TEM analysis. This
   study was financially supported by research project No. DI2016/009246
   (Ministry of Science and Higher Education, Poland) awarded to Joanna
   Szydlarska. We acknowledge the Leading National Research Centre (KNOW,
   Krajowy Naukowy Osrodek Wiodacy) program for years 2014-2018 for
   covering the publication fee.
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NR 43
TC 3
Z9 4
U1 0
U2 12
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1420-3049
J9 MOLECULES
JI Molecules
PD FEB
PY 2018
VL 23
IS 2
AR 287
DI 10.3390/molecules23020287
PG 15
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA FX9PK
UT WOS:000426436300067
PM 29385746
OA gold, Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Choudhury, J
   Sanyal, AJ
AF Choudhury, J
   Sanyal, AJ
TI Insulin resistance in NASH
SO FRONTIERS IN BIOSCIENCE-LANDMARK
LA English
DT Article
DE fatty liver; nonalcoholic steatohepatitis; nonalcoholic fatty liver
   disease; nonalcoholic fatty liver; insulin resistance; free fatty acids;
   oxidative stress; metabolic syndrome; obesity; review
ID ACTIVATED RECEPTOR-ALPHA; FATTY-ACID OXIDATION; PROTEIN-KINASE-C;
   HEPATIC CYTOCHROME-P450 2E1; PEROXISOMAL BETA-OXIDATION; METABOLIC
   SYNDROME; NONALCOHOLIC STEATOHEPATITIS; POTENTIAL ROLE; GLUCOSE-UPTAKE;
   LIVER-DISEASE
AB Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease observed in the clinical practice of hepatology. The coexistence of metabolic syndrome in this cohort of patients has made insulin resistance central to the pathogenesis of these disorders. The metabolic consequence of insulin resistance is impaired hepatic glucose output and abnormal lipid handling. In the face of continued metabolic insults the normal hepatic regulatory mechanism gets overwhelmed and fat accumulates in the hepatocytes. The subsequent fate of steatotic hepatocytes depends on the capacity of additional factors such as adipocytokines and toxicity induced by the free fatty acids themselves to induce inflammatory response. This latter process is responsible for the producing the phenotype of non-alcoholic steatohepatitis (NASH). Irrespective of the process by which these phenotypic response occurs, it is now universally accepted that in the absence of insulin resistance the spectrum of changes one associates with NAFLD does not develop. In this review we will discuss the various processes that are involved in the pathogenesis of NAFLD.
C1 Virginia Commonwealth Univ, Dept Internal Med, Div Gastroenterol Hepatol & Nutr, Richmond, VA USA.
C3 Virginia Commonwealth University
RP MCV Box 980711, Richmond, VA 23298 USA.
EM ajsanyal@hsc.vcu.edu
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NR 98
TC 41
Z9 46
U1 0
U2 1
PU FRONTIERS IN BIOSCIENCE INC
PI IRVINE
PA 16471 SCIENTIFIC WAY, IRVINE, CA 92618 USA
SN 1093-9946
EI 1093-4715
J9 FRONT BIOSCI-LANDMRK
JI Front. Biosci.
PD MAY 1
PY 2005
VL 10
BP 1520
EP 1533
PG 14
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA 970OP
UT WOS:000232319800043
PM 15769642
DA 2025-06-11
ER

PT J
AU Lai, MD
   Ong, KC
   Arumugam, B
   Kuppusamy, UR
AF Lai, Muhammad Dhia
   Ong, Kien Chai
   Arumugam, Bavani
   Kuppusamy, Umah Rani
TI Nutritional composition, efficacy and mechanisms of oyster mushrooms
   (Pleurotus spp.) in preventing metabolic syndrome: Insights into
   perspectives and challenges
SO FOOD BIOSCIENCE
LA English
DT Article
DE Pleurotus; Oyster mushrooms; Nutritional properties; Metabolic syndrome
ID EDIBLE MUSHROOMS; PROVISIONAL REPORT; GANODERMA-LUCIDUM; OXIDATIVE
   STRESS; AQUEOUS EXTRACT; FATTY LIVER; OSTREATUS; DIAGNOSIS; GLUCANS;
   POLYSACCHARIDES
AB The worldwide prevalence of metabolic syndrome (MetS) and its related complications such as diabetes and cardiovascular disease have been increasing steadily. Apart from realigning dietary intake habits and exercising regularly, consuming food with health benefits could help patients with MetS improve their health. Oyster mushrooms (genus Pleurotus) are among the most common edible mushrooms explored for potential use for combating MetS due to their high nutritional contents with additional bioactive components. Besides, numerous high-fat diets and drug-induced hyperglycemic animal studies have revealed the ability of oyster mushrooms to improve MetS-related conditions by targeting different mechanisms. Several clinical studies have shown varying efficacy levels of the mushrooms in combatting MetS and related complications. However, these findings have yet to be compared and reviewed to provide an overview and meaningful inferences on the benefits of the mushroom against MetS. This review will provide insights and updates on the nutritional composition, efficacy and mechanisms of oyster mushrooms in preventing or attenuating MetS-related conditions, as well as the perspectives and challenges of introducing these mushrooms as food products with health benefits.
C1 [Lai, Muhammad Dhia; Ong, Kien Chai; Arumugam, Bavani; Kuppusamy, Umah Rani] Univ Malaya, Fac Med, Dept Biomed Sci, Kuala Lumpur 50603, Malaysia.
   [Kuppusamy, Umah Rani] Univ Malaya, Mushroom Res Ctr, Kuala Lumpur 50603, Malaysia.
C3 Universiti Malaya; Universiti Malaya
RP Kuppusamy, UR (corresponding author), Univ Malaya, Fac Med, Dept Biomed Sci, Kuala Lumpur 50603, Malaysia.; Kuppusamy, UR (corresponding author), Univ Malaya, Mushroom Res Ctr, Kuala Lumpur 50603, Malaysia.
EM umah@um.edu.my
RI KUPPUSAMY, UMAH RANI/B-9981-2010; Arumugam, Bavani/GRR-5995-2022; ONG,
   KIEN CHAI/B-9452-2010; Lai, Muhammad Dhia/JSL-6141-2023
OI Lai, Muhammad Dhia/0009-0003-7572-5006
FU Universiti Malaya Impact Oriented Interdisciplinary Research Grant
   [IIRG005B-19HWB]
FX This research is supported by Universiti Malaya Impact Oriented
   Interdisciplinary Research Grant (IIRG005B-19HWB) .
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NR 211
TC 4
Z9 4
U1 6
U2 16
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2212-4292
EI 2212-4306
J9 FOOD BIOSCI
JI Food Biosci.
PD OCT
PY 2024
VL 61
AR 104768
DI 10.1016/j.fbio.2024.104768
EA JUL 2024
PG 18
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA ZZ3O9
UT WOS:001279070800001
DA 2025-06-11
ER

PT J
AU Vidal-Cevallos, P
   Sorroza-Martinez, AP
   Chavez-Tapia, NC
   Uribe, M
   Montalvo-Jave, EE
   Nuno-Lambarri, N
AF Vidal-Cevallos, Paulina
   Sorroza-Martinez, Adriana P.
   Chavez-Tapia, Norberto C.
   Uribe, Misael
   Montalvo-Jave, Eduardo E.
   Nuno-Lambarri, Natalia
TI The Relationship between Pathogenesis and Possible Treatments for the
   MASLD-Cirrhosis Spectrum
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE metabolic syndrome; sedentarism; fibrosis; hepatic steatosis;
   steatohepatitis; diet
ID NONALCOHOLIC FATTY LIVER; MEDITERRANEAN DIET; HEPATIC STEATOSIS;
   PHYSICAL-ACTIVITY; AEROBIC EXERCISE; LOW-CARBOHYDRATE;
   CARDIOVASCULAR-DISEASE; AMERICAN ASSOCIATION; INSULIN-RESISTANCE;
   METABOLIC SYNDROME
AB Metabolic dysfunction-associated steatotic liver disease (MASLD) is a term that entails a broad spectrum of conditions that vary in severity. Its development is influenced by multiple factors such as environment, microbiome, comorbidities, and genetic factors. MASLD is closely related to metabolic syndrome as it is caused by an alteration in the metabolism of fatty acids due to the accumulation of lipids because of an imbalance between its absorption and elimination in the liver. Its progression to fibrosis is due to a constant flow of fatty acids through the mitochondria and the inability of the liver to slow down this metabolic load, which generates oxidative stress and lipid peroxidation, triggering cell death. The development and progression of MASLD are closely related to unhealthy lifestyle habits, and nutritional epigenetic and genetic mechanisms have also been implicated. Currently, lifestyle modification is the first-line treatment for MASLD and nonalcoholic steatohepatitis; weight loss of >= 10% produces resolution of steatohepatitis and fibrosis regression. In many patients, body weight reduction cannot be achieved; therefore, pharmacological treatment should be offered in particular populations.
C1 [Vidal-Cevallos, Paulina; Chavez-Tapia, Norberto C.; Uribe, Misael; Montalvo-Jave, Eduardo E.] Med Sur Clin & Fdn, Obes & Digest Dis Unit, Mexico City 14050, DF, Mexico.
   [Sorroza-Martinez, Adriana P.; Chavez-Tapia, Norberto C.; Nuno-Lambarri, Natalia] Med Sur Clin & Fdn, Translat Res Unit, Mexico City 14050, DF, Mexico.
   [Montalvo-Jave, Eduardo E.; Nuno-Lambarri, Natalia] Univ Nacl Autonoma Mexico, Fac Med, Dept Surg, Mexico City 04360, DF, Mexico.
   [Montalvo-Jave, Eduardo E.] Hosp Gen Mex Dr Eduardo Liceaga, Dept Surg, Hepatopancreatobiliary Clin, Mexico City 06720, DF, Mexico.
C3 Universidad Nacional Autonoma de Mexico
RP Nuno-Lambarri, N (corresponding author), Med Sur Clin & Fdn, Translat Res Unit, Mexico City 14050, DF, Mexico.; Nuno-Lambarri, N (corresponding author), Univ Nacl Autonoma Mexico, Fac Med, Dept Surg, Mexico City 04360, DF, Mexico.
EM paulina.vice@gmail.com; paola.sorrozamtz@gmail.com;
   nchavezt@medicasur.org.mx; muribe@medicasur.org.mx;
   montalvoeduardo@hotmail.com; nnunol@medicasur.org.mx
RI Nuño-Lámbarri, Natalia/KBD-4162-2024
OI Chavez-Tapia, Norberto/0000-0002-7451-3306
FU Medica Sur Clinic and Foundation
FX We thank the Medica Sur Clinic and Foundation for their support in
   preparing this manuscript and BioRender.com for their support in
   creating the figures.
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NR 135
TC 8
Z9 8
U1 1
U2 3
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD APR
PY 2024
VL 25
IS 8
AR 4397
DI 10.3390/ijms25084397
PG 23
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA QJ3J0
UT WOS:001220464800001
PM 38673981
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Zhou, MT
   Hu, NH
   Liu, MC
   Deng, Y
   He, LF
   Guo, CC
   Zhao, XT
   Li, YX
AF Zhou, Mengting
   Hu, Naihua
   Liu, Meichen
   Deng, Ying
   He, Linfeng
   Guo, Chaocheng
   Zhao, Xingtao
   Li, Yunxia
TI A Candidate Drug for Nonalcoholic Fatty Liver Disease: A Review of
   Pharmacological Activities of Polygoni Multiflori Radix
SO BIOMED RESEARCH INTERNATIONAL
LA English
DT Review
ID NF-KAPPA-B; OXIDATIVE STRESS; HEPATIC STEATOSIS; GUT MICROBIOTA;
   STILBENE GLUCOSIDE; FREE-RADICALS; MOUSE MODEL; IN-VITRO; RESVERATROL;
   EMODIN
AB Nonalcoholic fatty liver disease, a type of metabolic syndrome, continues to rise globally. Currently, there is no approved drug for its treatment. Improving lifestyle and exercise can alleviate symptoms, but patients' compliance is poor. More and more studies have shown the potential of Polygoni Multiflori Radix (PMR) in the treatment of NAFLD and metabolic syndrome. Therefore, this paper reviews the pharmacological effects of PMR and its main chemical components (tetrahydroxystilbene glucoside, emodin, and resveratrol) on NAFLD. PMR can inhibit the production of fatty acids and promote the decomposition of triglycerides, reduce inflammation, and inhibit the occurrence of liver fibrosis. At the same time, it maintains an oxidation equilibrium status in the body, to achieve the therapeutic purpose of NAFLD and metabolic syndrome. Although more standardized studies and clinical trials are needed to confirm its efficacy, PMR may be a potential drug for the treatment of NAFLD and its complications. However, the occurrence of adverse reactions of PMR has affected its extensive clinical application. Therefore, it is necessary to further study its toxicity mechanism, enhance efficacy and control toxicity, and even reduce toxicity, which will contribute to the safe clinical use of PMR.
C1 [Zhou, Mengting; Hu, Naihua; Liu, Meichen; Deng, Ying; He, Linfeng; Guo, Chaocheng; Zhao, Xingtao; Li, Yunxia] Chengdu Univ Tradit Chinese Med, Sch Pharm, Chengdu 611137, Peoples R China.
   [Zhou, Mengting; Hu, Naihua; Liu, Meichen; Deng, Ying; He, Linfeng; Guo, Chaocheng; Zhao, Xingtao; Li, Yunxia] Minist Educ, Key Lab Standardizat Chinese Herbal Med, Chengdu 611137, Peoples R China.
   [Zhou, Mengting; Hu, Naihua; Liu, Meichen; Deng, Ying; He, Linfeng; Guo, Chaocheng; Zhao, Xingtao; Li, Yunxia] Natl Key Lab Breeding Base Systemat Res Dev & Uti, Chengdu 611137, Peoples R China.
C3 Chengdu University of Traditional Chinese Medicine; Ministry of
   Education - China
RP Li, YX (corresponding author), Chengdu Univ Tradit Chinese Med, Sch Pharm, Chengdu 611137, Peoples R China.; Li, YX (corresponding author), Minist Educ, Key Lab Standardizat Chinese Herbal Med, Chengdu 611137, Peoples R China.; Li, YX (corresponding author), Natl Key Lab Breeding Base Systemat Res Dev & Uti, Chengdu 611137, Peoples R China.
EM 760804167@qq.com; 364673561@qq.com; 245982034@qq.com; 1187979146@qq.com;
   623037768@qq.com; 1109261310@qq.com; 1806016946@qq.com;
   lyxcdutcm@126.com
RI Zhou, Mengting/ITU-0911-2023; zhao, xingtao/MCK-2881-2025; naihua,
   hu/GVU-8621-2022
OI Deng, Ying/0000-0003-1742-1197; zhao, xingtao/0000-0003-1668-0453; li,
   yunxia/0000-0003-1307-4335; He, Linfeng/0000-0001-7211-1170; Zhou,
   Mengting/0000-0002-2707-4902; Guo, Chaocheng/0000-0002-9490-1365; hu,
   naihua/0000-0002-9164-8827
FU National Natural Science Foundation of China (NSFC) [81373943,
   81573583]; Sichuan Provincial Science and Technology Department of Youth
   Science and Technology Innovation Research Team Program [2017TD0001]
FX The work was supported by the National Natural Science Foundation of
   China (NSFC) (Grant Nos. 81373943 and 81573583) and the Sichuan
   Provincial Science and Technology Department of Youth Science and
   Technology Innovation Research Team Program (2017TD0001).
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NR 150
TC 7
Z9 9
U1 2
U2 15
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2314-6133
EI 2314-6141
J9 BIOMED RES INT
JI Biomed Res. Int.
PD APR 22
PY 2020
VL 2020
AR 5462063
DI 10.1155/2020/5462063
PG 19
WC Biotechnology & Applied Microbiology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Research & Experimental Medicine
GA LM7AD
UT WOS:000532400200010
PM 32382557
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Iorga, RA
   Bacalbasa, N
   Bratu, OG
   Radu, FI
   Diaconu, CC
AF Iorga, Roua A.
   Bacalbasa, Nicolae
   Bratu, Ovidiu G.
   Radu, Florentina Ionita
   Diaconu, Camelia C.
TI The impact of infection with hepatitis C virus on cardiovascular risk
SO AMERICAN JOURNAL OF CARDIOVASCULAR DISEASE
LA English
DT Review
DE Hepatitis C virus; insulin resistance; cardiovascular risk; metabolic
   syndrome; diabetes mellitus
ID CHRONIC HCV INFECTION; METABOLIC SYNDROME; DIABETES-MELLITUS;
   ATHEROSCLEROSIS; DISEASE; RIBAVIRIN; DASABUVIR; FOCUS
AB Chronic hepatitis C virus (HCV) infection represents a systemic disease, with a natural progression to hepatic steatosis, fibrosis, and finally, cirrhosis, with an increased risk of hepatocellular carcinoma. Besides the hepatic alterations, the systemic manifestations of chronic HCV infection, such as endothelial dysfunction and atherosclerosis, oxidative stress, insulin resistance, immunological alterations, are nowadays recognized as cardiovascular risk factors. Hepatitis C is associated with insulin resistance and increased risk for type 2 diabetes mellitus, carotid atherosclerosis and stroke, coronary artery disease and chronic heart failure, with a significant impact on the mortality and morbidity. This article represents an overview of the most prevalent and important systemic alterations of chronic HCV infection, with emphasis on their cardiovascular and metabolic effects due to a treatable disease.
C1 [Iorga, Roua A.; Diaconu, Camelia C.] Clin Emergency Hosp Bucharest, Bucharest, Romania.
   [Bacalbasa, Nicolae; Bratu, Ovidiu G.; Diaconu, Camelia C.] Univ Med & Pharm Carol Davila, Bucharest, Romania.
   [Bacalbasa, Nicolae] I Cantacuzino Clin Hosp, Bucharest, Romania.
   [Bratu, Ovidiu G.] Emergency Univ Cent Mil Hosp, Bucharest, Romania.
   [Bratu, Ovidiu G.] Acad Romanian Scientists, Bucharest, Romania.
   [Radu, Florentina Ionita] Univ Emergency Cent Mil Hosp Dr Carol Davila, Bucharest, Romania.
C3 Carol Davila University of Medicine & Pharmacy; Academy of Romanian
   Scientists (AOSR)
RP Diaconu, CC (corresponding author), Carol Davila Univ Med & Pharm, Internal Med Dept, Clin Emergency Hosp Bucharest, 8 Calea Floreasca, Bucharest 014461, Romania.
EM drcameliadiaconu@gmail.com
RI bacalbasa, nicolae/HJZ-4552-2023; Bratu, Ovidiu/L-3040-2019; Diaconu,
   Camelia/A-2144-2019; Ionita Radu, Florentina/ADP-0898-2022
OI Ionita Radu, Florentina/0000-0001-9829-5035
CR Adinolfi LE, 2013, ATHEROSCLEROSIS, V231, P22, DOI 10.1016/j.atherosclerosis.2013.08.003
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NR 30
TC 10
Z9 10
U1 0
U2 1
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 2160-200X
J9 AM J CARDIOVASC DIS
JI Am. J. Cardiovasc. Dis.
PY 2020
VL 10
IS 3
BP 201
EP 206
PG 6
WC Cardiac & Cardiovascular Systems
WE Emerging Sources Citation Index (ESCI)
SC Cardiovascular System & Cardiology
GA OA0RZ
UT WOS:000577505400009
PM 32923102
DA 2025-06-11
ER

PT J
AU Rodriguez-Peredo, SM
   Castellanos-Jankiewicz, AK
   Imaz-Rosshandler, I
   Espinoza-Camacho, MA
   Rangel-Escareño, C
   Muñoz-Sánchez, JL
   Melendez-Zajgla, J
   Tejero, ME
   Carbo, R
   Maldonado, V
   del Bosque-Plata, L
AF Rodriguez-Peredo, Sofia M.
   Castellanos-Jankiewicz, Ashley K.
   Imaz-Rosshandler, Ivan
   Espinoza-Camacho, Miguel A.
   Rangel-Escareno, Claudia
   Munoz-Sanchez, Jose L.
   Melendez-Zajgla, Jorge
   Elizabeth Tejero, M.
   Carbo, Roxana
   Maldonado, Vilma
   del Bosque-Plata, Laura
TI Modulation of the lung RNAome in a metabolic syndrome rat model
SO INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY
LA English
DT Article
DE Metabolic syndrome; lung; rats; RNAome; high sucrose diet
ID OBSTRUCTIVE PULMONARY-DISEASE; SYSTEMIC INFLAMMATION;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; FUNCTION IMPAIRMENT; MELATONIN;
   ASTHMA; RISK; CHOLESTEROL; HOMEOSTASIS
AB Metabolic syndrome (MetS) is characterized by a constellation of conditions that increase the risk for heart disease and other health problems. Although multiple organs are affected by this syndrome, research that focuses on the organs that are not directly involved in metabolism is lacking. Because MetS increases the risk for various lung diseases, we explored the effects of MetS on the lung in this study. We observed that the chronic consumption of a high sucrose diet for 24 weeks induced MetS in a rat model. Concomitant expression changes in 1,026 coding genes and two microRNAs were observed in the analyzed lung tissues. A network analysis showed degradation changes in the melatonin pathway, which plays a protective role in the lung; impairments of several inflammatory pathways (i.e., interferon-gamma and nuclear factor kappa B) were also revealed. Moreover, multiple olfactory genes were unexpectedly deregulated. Overall, the lungs of MetS mice exhibited an inflammatory phenotype with molecular changes that affected several signaling pathways that were related to melatonin metabolism, olfactory receptors and cytokine production. Additional research will be necessary to dissect a possible mechanism for the effects of this syndrome on the lung.
C1 [Rodriguez-Peredo, Sofia M.; Castellanos-Jankiewicz, Ashley K.; Imaz-Rosshandler, Ivan; Espinoza-Camacho, Miguel A.; Elizabeth Tejero, M.; del Bosque-Plata, Laura] Inst Nacl Med Genom, Lab Nutrigenet & Nutrigen, Perifer Sur 4809, Mexico City 14610, DF, Mexico.
   [Rodriguez-Peredo, Sofia M.; Munoz-Sanchez, Jose L.] Inst Politecn Nacl, Escuela Nacl Ciencias Biol, Prolongac Carpio & Plan Ayala S-N, Mexico City 11340, DF, Mexico.
   [Carbo, Roxana] Inst Nacl Cardiol Ignacio Chavez, Dept Biomed Cardiovasc, Juan Badiano 1,Col Secc 16, Mexico City 14080, DF, Mexico.
   [Rangel-Escareno, Claudia] Inst Nacl Med Genom, Lab Genom Comp, Perifer Sur 4809, Mexico City 14610, DF, Mexico.
   [Melendez-Zajgla, Jorge] Inst Nacl Med Genom, Lab Genom Func, Perifer Sur 4809, Mexico City 14610, DF, Mexico.
   [Maldonado, Vilma] Inst Nacl Med Genom, Lab Epigenet, Perifer Sur 4809, Mexico City 14610, DF, Mexico.
   [Espinoza-Camacho, Miguel A.] Univ Nacl Autonoma Mexico, Posgrad Ciencias Biol, Ave Univ 3000, Mexico City 04510, DF, Mexico.
C3 Instituto Nacional de Medicina Genomica; Instituto Politecnico Nacional
   - Mexico; National Institute of Cardiology - Mexico; Instituto Nacional
   de Medicina Genomica; Instituto Nacional de Medicina Genomica; Instituto
   Nacional de Medicina Genomica; Universidad Nacional Autonoma de Mexico
RP del Bosque-Plata, L (corresponding author), Inst Nacl Med Genom, Lab Nutrigenet & Nutrigen, Perifer Sur 4809, Mexico City 14610, DF, Mexico.
EM ldelbosque@inmegen.gob.mx
RI Tejero, Maria/MBV-3355-2025; Carbó, Roxana/ABC-1951-2020;
   Melendez-Zajgla, Jorge/A-5708-2008; Rangel-Escareno, Claudia/F-4587-2012
OI Rangel-Escareno, Claudia/0000-0003-1303-0834; Carbo,
   Roxana/0000-0002-3581-398X
FU National Council for Science and Technology (CONACYT) [230762, 324898];
   CONACyT [169652]; National Institute of Cardiology "Ignacio Chavez"
   (SSA); Histology and Confocal Microscopy Facility of the INMEGEN; Gene
   Expression and Genotyping Facility of the INMEGEN
FX This work was supported by a PhD scholarship that was received by SMRP
   from the National Council for Science and Technology (CONACYT #230762,
   #324898) and by the following financial project: CONACyT, No. project
   169652, "Study of gene expression in the hypothalamus-adipose axis in a
   rat model with metabolic syndrome", Project manager: Laura del
   Bosque-Plata, Ph.D. We are thankful for the financial support of the
   National Institute of Cardiology "Ignacio Chavez" (SSA) for the animal
   model. We also thank the Histology and Confocal Microscopy Facility and
   the Gene Expression and Genotyping Facility of the INMEGEN for their
   support of this investigation.
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NR 49
TC 0
Z9 0
U1 0
U2 2
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 1936-2625
J9 INT J CLIN EXP PATHO
JI Int. J. Clin. Exp. Pathol.
PY 2017
VL 10
IS 5
BP 5379
EP +
PG 15
WC Oncology; Pathology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Pathology
GA EW1UG
UT WOS:000402279600044
DA 2025-06-11
ER

PT J
AU Taranu, I
   Racataianu, N
   Drugan, C
   Catana, CS
   Mirea, AM
   Miclea, D
   Bolboaca, SD
AF Taranu, Ioana
   Racataianu, Nicoleta
   Drugan, Cristina
   Catana, Cristina-Sorina
   Mirea, Andreea-Manuela
   Miclea, Diana
   Bolboaca, Sorana D.
TI Exploratory Longitudinal Analysis of the Circulating CHIT1 Activity in
   Pediatric Patients with Obesity
SO CHILDREN-BASEL
LA English
DT Article
DE human chitotriosidase (CHIT1); longitudinal analysis; children; obesity;
   insulin resistance (IR); inflammation; puberty; abdominal obesity; 24
   base-pair duplication
ID SUBCUTANEOUS ADIPOSE-TISSUE; BODY-MASS INDEX; CARDIOMETABOLIC
   RISK-FACTORS; HDL-CHOLESTEROL RATIO; ENDOPLASMIC-RETICULUM STRESS; 3RD
   NATIONAL-HEALTH; INSULIN-RESISTANCE; METABOLIC SYNDROME; CHITOTRIOSIDASE
   ACTIVITY; WAIST CIRCUMFERENCE
AB Macrophage activation and cytokine release play a pivotal role in inflammation-mediated metabolic disturbances in obesity. The proinflammatory macrophage secretes human chitotriosidase (CHIT1). The expression of the CHIT1 in visceral adipose tissue is associated with cytokine production. Our study aimed to assess whether the CHIT1 circulating activity, as a macrophage activation indicator, reflects the change of the adiposity level and the insulin resistance (IR) in children with obesity. We longitudinally (median follow-up period of 7 months; IQR [5 to 8.5] and {2 to 13} months) evaluated the CHIT1 circulating activity, the adiposity level (waist circumference (WC), waist-to-hip ratio (WHR), waist-to-height ratio (WtHR), and body mass index (BMI)-for-age z score), and two surrogate markers of IR (Homeostatic Model Assessment for Insulin Resistance, HOMA-IR and the triglycerides-to-high density lipoprotein cholesterol ratio, TG/HDLc) in 29 pediatric patients (16 girls and 13 boys) with obesity. We found a significant reduction in CHIT1 circulating activity (Wilcoxon test, p = 0.015) and a decrease in TG/HDLc at the follow-up evaluation (Wilcoxon test, p < 0.001). Indicators of adiposity were positively correlated with HOMA-IR at baseline, among which WC was the sole indicator associated with HOMA-IR (Spearman's rank correlation coefficients, p < 0.05) at follow-up. Human chitotriosidase has the potential to be a valuable measure of the progression of subclinical inflammation in children with obesity. Subclinical inflammation, as expressed by the circulating CHIT1 activity, progresses independently of the abdominal adiposity, as measured by the clinical indicators, and is associated with a change in insulin resistance.
C1 [Taranu, Ioana; Bolboaca, Sorana D.] Iuliu Hatieganu Univ Med & Pharm, Dept Med Informat & Biostat, Louis Pasteur Str,6, Cluj Napoca 400349, Romania.
   [Taranu, Ioana; Mirea, Andreea-Manuela] Emergency Pediat Hosp, Pediat Clin 1, Calea Motilor 68, Cluj Napoca 400370, Romania.
   [Racataianu, Nicoleta] Infect Dis Clin Hosp, Integrated Ambulatory Endocrinol, Calea Motilor 19, Cluj Napoca 400000, Romania.
   [Drugan, Cristina; Catana, Cristina-Sorina] Iuliu Hatieganu Univ Med & Pharm Cluj Napoca, Dept Med Biochem, Louis Pasteur Str,6, Cluj Napoca 400349, Romania.
   [Miclea, Diana] Iuliu Hatieganu Univ Med & Pharm, Dept Med Genet, Louis Pasteur Str,6, Cluj Napoca 400349, Romania.
C3 Iuliu Hatieganu University of Medicine & Pharmacy; Iuliu Hatieganu
   University of Medicine & Pharmacy; Iuliu Hatieganu University of
   Medicine & Pharmacy
RP Bolboaca, SD (corresponding author), Iuliu Hatieganu Univ Med & Pharm, Dept Med Informat & Biostat, Louis Pasteur Str,6, Cluj Napoca 400349, Romania.
EM sbolboaca@umfcluj.ro
RI catana, cristina/AGO-3947-2022; Gheorghiu, Ioana/JXN-8469-2024; Mirea,
   Andreea-Manuela/I-3147-2018; Drugan, Cristina/C-8534-2015; Bolboaca,
   Sorana D./E-4457-2010
OI Catana, Cristina/0000-0002-8899-6265; Drugan,
   Cristina/0000-0001-9136-2530; Gheorghiu, Ioana/0000-0002-7779-3147;
   Racataianu, Nicoleta/0000-0002-4397-3182; Bolboaca, Sorana
   D./0000-0002-2342-4311
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NR 97
TC 0
Z9 0
U1 1
U2 5
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2227-9067
J9 CHILDREN-BASEL
JI Children-Basel
PD JAN
PY 2023
VL 10
IS 1
AR 124
DI 10.3390/children10010124
PG 13
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA 7X9RT
UT WOS:000914530800001
PM 36670674
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Mazidi, M
   Katsiki, N
   Mikhailidis, DP
   Banach, M
AF Mazidi, Mohsen
   Katsiki, Niki
   Mikhailidis, Dimitri P.
   Banach, Maciej
TI Link between plasma trans-fatty acid and fatty liver is moderated
   by adiposity
SO INTERNATIONAL JOURNAL OF CARDIOLOGY
LA English
DT Article
DE Trans-fatty acids; Non-alcoholic fatty liver disease; Liver tests; Fatty
   liver index; Body mass
ID OXIDATIVE STRESS; INSULIN-RESISTANCE; METABOLIC SYNDROME; DISEASE;
   INFLAMMATION; DIETS; STEATOHEPATITIS; SEVERITY; INJURY; BLOOD
AB Background: The prevalence of non-alcoholic fatty liver disease (NAFLD) is rising. This increase may be associated with obesity. It has been suggested that trans-fatty acids (TFAs) play an important role in non-communicable diseases.
   Aim: We examined the link between liver tests, fatty liver index (FLI) and plasma TFAs. Furthermore, we evaluated the impact of adiposity on this link.
   Methods: The National Health and Nutrition Examination Survey (NHANES) was used to obtain the data on TFAs and liver function biomarkers. We took account of complex NHANES data, masked variance and weighting methodology.
   Results: Of the 4252 participants, 46.4% were men. The mean age was 50.6 years overall; 51.3 years for men and 49.8 years for women (p - 0.206). In a fully adjusted model (demographic and clinical factors), FU increased as trans-9-hexadecenoic acid and trans-11-octadecenoic acid levels increased; FLI was 38.1 and 42.3 for the first quarter (Q1) of trans-9-hexadecenoic acid and trans-11-octadecenoic add, respectively, reaching 65.1 and 69.3 for the highest quarters (Q4) (p < 0.001 for all comparisons). Multivariable logistic regression showed for all four studied TFAs, the likelihood of NAFLD (determined by FU) increased with increasing TFAs levels (quartiles) in a stepwise manner (p < 0.001 for all comparisons). Based on moderation analysis, a strong impact of body mass index (BMI) on the link between FLI and TFAs was observed.
   Conclusions: Our results suggest a direct significant association between plasma TFAs, liver tests and NAFLD (assessed by FU). Furthermore, BMI was shown to mediate this relationship. These findings highlight the importance of avoiding TFAs consumption in order to minimize cardiometabolic risk. (C) 2018 Published by Elsevier B.V.
C1 [Mazidi, Mohsen] Chalmers Univ Technol, Dept Biol & Biol Engn, Food & Nutr Sci, SE-41296 Gothenburg, Sweden.
   [Katsiki, Niki] Aristotle Univ Thessaloniki, Med Sch, Propedeut Dept Internal Med 2, Hippokrat Hosp, Thessaloniki, Greece.
   [Mikhailidis, Dimitri P.] UCL, Med Sch, Dept Clin Biochem, Royal Free Campus, London, England.
   [Banach, Maciej] Med Univ Lodz, Chair Nephrol & Hypertens, Dept Hypertens, Lodz, Poland.
   [Banach, Maciej] PMMHRI, Lodz, Poland.
   [Banach, Maciej] Univ Zielona Gora, Cardiovasc Res Ctr, Zielona Gora, Poland.
C3 Chalmers University of Technology; Aristotle University of Thessaloniki;
   University of London; University College London; Medical University
   Lodz; University of Zielona Gora
RP Mazidi, M (corresponding author), Chalmers Univ Technol, Dept Biol & Biol Engn, Food & Nutr Sci, SE-41296 Gothenburg, Sweden.
EM mazidi@chalmers.se
RI Linn, Shai/N-3079-2019; Mikhailidis, Dimitri/A-1869-2013; KATSIKI,
   NIKI/ADE-7999-2022; Banach, Maciej/A-1271-2009
OI KATSIKI, NIKI/0000-0003-0894-2644; Banach, Maciej/0000-0001-6690-6874
FU TWAS studentship of the Chinese Academy of Sciences
FX MM was supported by a TWAS studentship of the Chinese Academy of
   Sciences.
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NR 50
TC 17
Z9 19
U1 0
U2 20
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0167-5273
EI 1874-1754
J9 INT J CARDIOL
JI Int. J. Cardiol.
PD DEC 1
PY 2018
VL 272
BP 316
EP 322
DI 10.1016/j.ijcard.2018.07.061
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA GV3VI
UT WOS:000446025200066
PM 30072152
DA 2025-06-11
ER

PT S
AU Puttabyatappa, M
   Padmanabhan, V
AF Puttabyatappa, Muraly
   Padmanabhan, Vasantha
BE MauvaisJarvis, F
TI Prenatal Testosterone Programming of Insulin Resistance in the Female
   Sheep
SO SEX AND GENDER FACTORS AFFECTING METABOLIC HOMEOSTASIS, DIABETES AND
   OBESITY
SE Advances in Experimental Medicine and Biology
LA English
DT Article; Book Chapter
ID POLYCYSTIC-OVARY-SYNDROME; CATCH-UP GROWTH; METABOLIC SYNDROME;
   UNITED-STATES; DEVELOPMENTAL ORIGINS; OXIDATIVE STRESS; EXCESS;
   SENSITIVITY; ADIPONECTIN; OBESITY
AB Insulin resistance, a common feature of metabolic disorders such as obesity, nonalcoholic fatty liver disease, metabolic syndrome, and polycystic ovary syndrome, is a risk factor for development of diabetes. Because sex hormones orchestrate the establishment of sex-specific behavioral, reproductive, and metabolic differences, a role for them in the developmental origin of insulin resistance is also to be expected. Female sheep exposed to male levels of testosterone during fetal life serve as an excellent translational model for delineating programming of insulin resistance. This chapter summarizes the ontogeny of insulin resistance, the tissue-specific changes in insulin sensitivity, and the various factors that are involved in the programming and maintenance of the insulin resistance in adult female sheep that were developmentally exposed to fetal male levels of testosterone during the sexual-differentiation window.
C1 [Puttabyatappa, Muraly; Padmanabhan, Vasantha] Univ Michigan, Dept Pediat, Ann Arbor, MI 48109 USA.
C3 University of Michigan System; University of Michigan
RP Padmanabhan, V (corresponding author), Univ Michigan, Dept Pediat, Ann Arbor, MI 48109 USA.
EM vasantha@umich.edu
RI Puttabyatappa, Muraly/K-2598-2015
FU NIH [P01 HD44232]
FX This work was supported by NIH P01 HD44232.
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NR 83
TC 19
Z9 19
U1 0
U2 1
PU SPRINGER INTERNATIONAL PUBLISHING AG
PI CHAM
PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND
SN 0065-2598
EI 2214-8019
BN 978-3-319-70178-3; 978-3-319-70177-6
J9 ADV EXP MED BIOL
JI Adv.Exp.Med.Biol.
PY 2017
VL 1043
BP 575
EP 596
DI 10.1007/978-3-319-70178-3_25
D2 10.1007/978-3-319-70178-3
PG 22
WC Biochemical Research Methods; Biochemistry & Molecular Biology;
   Endocrinology & Metabolism; Medicine, Research & Experimental
WE Book Citation Index – Science (BKCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism; Research &
   Experimental Medicine
GA BS3UO
UT WOS:000715520200028
PM 29224111
DA 2025-06-11
ER

PT J
AU Lisboa, QC
   Costa, SMF
   Couto, CA
AF Lisboa, Quelson Coelho
   Ferolla Costa, Silvia Marinho
   Couto, Claudia Alves
TI Current management of non-alcoholic fatty liver disease
SO REVISTA DA ASSOCIACAO MEDICA BRASILEIRA
LA English
DT Review
DE non-alcoholic fatty liver disease; steatosis; steatohepatitis; metabolic
   syndrome; obesity
ID PLACEBO-CONTROLLED TRIAL; BARIATRIC SURGERY; VITAMIN-E; CARDIOVASCULAR
   EVENTS; URSODEOXYCHOLIC ACID; PHYSICAL-ACTIVITY; DOUBLE-BLIND;
   WEIGHT-LOSS; STEATOHEPATITIS; PIOGLITAZONE
AB Non-alcoholic fatty liver disease (NAFLD) is characterized by hepatic accumulation of lipid in patients who do not consume alcohol in amounts generally considered harmful to the liver. NAFLD is becoming a major liver disease in Eastern countries and it is related to insulin resistance and metabolic syndrome. Treatment has focused on improving insulin sensitivity, protecting the liver from oxidative stress, decreasing obesity and improving diabetes mellitus, dyslipidemia, hepatic inflammation and fibrosis. Lifestyle modification involving diet and enhanced physical activity associated with the treatment of underlying metabolic are the main stain in the current management of NAFLD. Insulin-sensitizing agents and antioxidants, especially thiazolidinediones and vitamin E, seem to be the most promising pharmacologic treatment for non-alcoholic steatohepatitis, but further long-term multicenter studies to assess safety are recommended.
C1 [Lisboa, Quelson Coelho] Univ Fed Minas Gerais, Hosp Clin, Inst Alfa Gastroenterol, Sci Appl Adult Hlth Emphasis Gastroenterol, Belo Horizonte, MG, Brazil.
   [Ferolla Costa, Silvia Marinho] Univ Fed Minas Gerais, Hosp Clin, Inst Alfa Gastroenterol, Sci Appl Adult Hlth, Belo Horizonte, MG, Brazil.
   [Couto, Claudia Alves] Univ Fed Minas Gerais, Hosp Clin, Inst Alfa Gastroenterol, Fac Med, Belo Horizonte, MG, Brazil.
C3 Universidade Federal de Minas Gerais; Universidade Federal de Minas
   Gerais; Universidade Federal de Minas Gerais
RP Lisboa, QC (corresponding author), Ave Prof Alfredo Balena 110, BR-30130100 Belo Horizonte, MG, Brazil.
EM quelsoncoelho@gmail.com
RI Couto, Claudia/H-7420-2013
OI Couto, Claudia/0000-0002-9776-4757
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NR 53
TC 11
Z9 13
U1 2
U2 7
PU ASSOC MEDICA BRASILEIRA
PI SAO PAULO
PA RUA SAO CARLOS DO PINHAL 324, CAIXA POSTAL 8904, SAO PAULO, SP, BRAZIL
EI 1806-9282
J9 REV ASSOC MED BRAS
JI Rev. Assoc. Med. Bras.
PD DEC
PY 2016
VL 62
IS 9
BP 872
EP 878
DI 10.1590/1806-9282.62.09.872
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA EH4CN
UT WOS:000391718700015
PM 28001263
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Hulsmans, M
   De Keyzer, D
   Holvoet, P
AF Hulsmans, Maarten
   De Keyzer, Dieuwke
   Holvoet, Paul
TI MicroRNAs regulating oxidative stress and inflammation in relation to
   obesity and atherosclerosis
SO FASEB JOURNAL
LA English
DT Review
DE cardiovascular diseases; metabolic syndrome; vascular tissue; adipose
   tissue; microvesicles
ID C-REACTIVE PROTEIN; ADIPOSE-TISSUE MACROPHAGES; CORONARY-ARTERY-DISEASE;
   LOW-DENSITY-LIPOPROTEIN; ADIPOCYTE DIFFERENTIATION; INSULIN-RESISTANCE;
   METABOLIC SYNDROME; GENE-EXPRESSION; ENDOTHELIAL DYSFUNCTION;
   CARDIOVASCULAR-DISEASE
AB A primary event in atherogenesis is the infiltration of activated inflammatory cells into the arterial wall. There they secrete reactive oxygen species and oxidize lipoproteins, inducing foam cell formation and endothelial cell apoptosis, which in turn lead to plaque growth, erosion, and rupture. In addition, there is evidence that this vicious circle between oxidative stress and inflammation occurs not only in the diseased arterial wall but also in adipose tissues in obesity. In this condition, oxidative stress and inflammation impair adipocyte maturation, resulting in defective insulin action and adipocytokine signaling. This observation raises questions regarding what molecules are probably common regulators of these pathogenic processes in adipose and vascular tissues. Candidates are small, noncoding, microRNAs (miRs) that control gene expression by inducing mRNA degradation or blocking translation. This review summarizes recent insights into the roles of miRs in regulation of oxidative stress and inflammation in vascular and adipose tissues. It emphasizes the role of miR-containing microvesicles in the interaction between inflammatory cells and endothelial cells within these tissues and in communication between these tissues, possibly explaining the similarity and the simultaneity of molecular changes and interactions in adipose and vascular tissues.-Hulsmans, M., De Keyzer, D., Holvoet, P. MicroRNAs regulating oxidative stress and inflammation in relation to obesity and atherosclerosis. FASEB J. 25, 2515-2527 (2011). www.fasebj.org
C1 [Hulsmans, Maarten; De Keyzer, Dieuwke; Holvoet, Paul] Katholieke Univ Leuven, Dept Cardiovasc Dis, Atherosclerosis & Metab Unit, B-3000 Louvain, Belgium.
C3 KU Leuven
RP Holvoet, P (corresponding author), Katholieke Univ Leuven, Dept Cardiovasc Dis, Atherosclerosis & Metab Unit, Herestr 49,O&N1,PB 705, B-3000 Louvain, Belgium.
EM paul.holvoet@med.kuleuven.be
RI HOLVOET, PAUL/T-8434-2017; Hulsmans, Maarten/AAI-9547-2020
OI Holvoet, Paul/0000-0001-9201-0772; Hulsmans, Maarten/0000-0003-1009-658X
FU Belgian Federal Government [P06/30]; Katholieke Universiteit Leuven
   [PF/10/014]; Fonds voor Wetenschappelijk Onderzoek-Vlaanderen
   [G.0846.11]
FX Funding was provided by the Interuniversitaire Attractiepolen Programma
   of the Belgian Federal Government (P06/30), the Bijzonder
   Onderzoeksfonds of the Katholieke Universiteit Leuven (PF/10/014), and
   the Fonds voor Wetenschappelijk Onderzoek-Vlaanderen (G.0846.11 and
   Vascular Biology Network).
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NR 144
TC 196
Z9 221
U1 1
U2 31
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0892-6638
EI 1530-6860
J9 FASEB J
JI Faseb J.
PD AUG
PY 2011
VL 25
IS 8
BP 2515
EP 2527
DI 10.1096/fj.11-181149
PG 13
WC Biochemistry & Molecular Biology; Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 800CV
UT WOS:000293337800003
PM 21507901
DA 2025-06-11
ER

PT J
AU Berenbaum, F
AF Berenbaum, Francis
TI Diabetes-induced osteoarthritis: from a new paradigm to a new phenotype
SO ANNALS OF THE RHEUMATIC DISEASES
LA English
DT Article
ID GLYCATION END-PRODUCTS; METABOLIC SYNDROME; GLUCOSE-TRANSPORT; OXIDATIVE
   STRESS; KNEE; CHONDROCYTES; HYPERGLYCEMIA; ACTIVATION; CARTILAGE;
   RECEPTOR
AB Several epidemiological and experimental data support the hypothesis that diabetes could be an independent risk factor for osteoarthritis (OA), at least in some patients, leading to the concept of a diabetes-induced OA phenotype. If confirmed, this new paradigm will have a dramatic impact on prevention of OA initiation and progression.
C1 Univ Paris 06, St Antoine Hosp, APHP, Dept Rheumatol, Paris, France.
C3 Assistance Publique Hopitaux Paris (APHP); Universite Paris Cite;
   Hopital Universitaire Hotel-Dieu - APHP; Hopital Universitaire
   Ambroise-Pare - APHP; Sorbonne Universite; Hopital Universitaire
   Saint-Antoine - APHP
RP Berenbaum, F (corresponding author), Univ Paris 06, St Antoine Hosp, APHP, Dept Rheumatol, Paris, France.
EM francis.berenbaum@sat.aphp.fr
RI Berenbaum, Francis/AAO-5690-2020
OI berenbaum, francis/0000-0001-8252-7815
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NR 37
TC 122
Z9 134
U1 1
U2 23
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 0003-4967
EI 1468-2060
J9 ANN RHEUM DIS
JI Ann. Rheum. Dis.
PD AUG
PY 2011
VL 70
IS 8
BP 1354
EP 1356
DI 10.1136/ard.2010.146399
PG 3
WC Rheumatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Rheumatology
GA 784WC
UT WOS:000292188100002
PM 21474484
DA 2025-06-11
ER

PT J
AU Yu, BB
   Zhang, XY
   Wang, CP
   Sun, MZ
   Jin, LN
   Liu, X
AF Yu, Binbin
   Zhang, Xueyuan
   Wang, Chunpeng
   Sun, Mengzi
   Jin, Lina
   Liu, Xin
TI Trends in depression among Adults in the United States, NHANES 2005-2016
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Depression; Trends; Risk factor; NHANES
ID QUALITY-OF-LIFE; GENDER-DIFFERENCES; METABOLIC SYNDROME;
   MENTAL-DISORDERS; NATIONAL-HEALTH; PREVALENCE; EPIDEMIOLOGY;
   HYPERTENSION; ASSOCIATION; SYMPTOMS
AB Objectives: To describe the prevalence and trends of mild, moderate and severe depression among adults and all age groups in the US from 2005 to 2016, and analysis the risk factors for depression.
   Methods: This study analyzed the prevalence and association with risk factors of depression using weighted univariate logistic regression model. Data of NHANES 2005-2016 were used.
   Results: This study analyzed 29,303 participants. From 2005 through 2016, the trends of severe depression increased among >= 20 years (p for trend = 0.026, difference, 0.109[0.012,0.207]); severe depression increased among >= 65 years (p for trend <0.001, difference, 0.302[0.170,0.435]); and moderate depression increased among 20-39 years (p for trend = 0.028, difference, 0.137[0.045,0.229]). In adults, the odds ratios (OR)(95% confidence intervals (CI)) of mild depression for < 25000$ was 2.24 (1.96, 2.55), moderate depression was 4.94(3.91,6.24), and severe depression was 6.45(4.78,8.71); the OR(95%CI) of mild depression for smoking was 1.69(1.55,1.84), moderate depression was 2.94(2.57,3.35), and severe depression was 3.36(2.87,3.93); the OR (95%CI) of mild depression for hypertension was1.27(1.18,1.38), moderate depression was1.50(1.31,1.73), and severe depression was 1.94(1.61,2.34); the OR(95%CI) of mild depression for diabetes mellitus was1.45(1.30,1.61), moderate depression was1.83(1.51,2.22), and severe depression was 2.05(1.70,2.48).
   Conclusions: There was an increasing trend of severe depression in American adults, which was mainly manifested in the increasing trend of severe depression in the population >= 65 years. And the trend of moderate depression increased in 20-39 years. In addition, lower income, smoking, hypertension and diabetes mellitus increased the risk of depression, and the risk increased with the degree of depression.
C1 [Yu, Binbin; Zhang, Xueyuan; Sun, Mengzi; Jin, Lina; Liu, Xin] Jilin Univ, Sch Publ Hlth, Dept Epidemiol & Stat, Changchun 130021, Peoples R China.
   [Wang, Chunpeng] Northeast Normal Univ, Sch Math & Stat, Changchun, Jilin, Peoples R China.
C3 Jilin University; Northeast Normal University - China
RP Jin, LN; Liu, X (corresponding author), Jilin Univ, Sch Publ Hlth, Dept Epidemiol & Stat, Changchun 130021, Peoples R China.
EM jinln@jlu.edu.cn; liuxinjlu01@163.com
RI jin, lina/KRO-4922-2024
OI Sun, Mengzi/0000-0001-8001-8064
FU National Key Research and Development Program of China [2017YFC0108602]
FX This work was supported by The National Key Research and Development
   Program of China [grant number 2017YFC0108602].
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NR 50
TC 80
Z9 90
U1 10
U2 74
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD FEB 15
PY 2020
VL 263
BP 609
EP 620
DI 10.1016/j.jad.2019.11.036
PG 12
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA KE9MP
UT WOS:000508874400081
PM 31744739
DA 2025-06-11
ER

PT J
AU Kim, H
   Kang, S
   Go, GW
AF Kim, Hayoon
   Kang, Sumin
   Go, Gwang-woong
TI Black beans (Glycine max (L.) Merrill) included in a multi-grain
   rice reduce total cholesterol and enhance antioxidant capacity in
   high-fat diet-induced obese mice
SO FOOD SCIENCE AND BIOTECHNOLOGY
LA English
DT Article
DE Antioxidant; Black bean; Body composition; Dyslipidemia; Growth
   performance; Obesity
ID OXIDATIVE STRESS; METABOLIC SYNDROME; RECEPTOR; MUSCLE
AB This study investigated the effects of black bean (BB) supplementation on the growth performance, lipid metabolism, and antioxidant capacity of high-fat diet-induced obese mice. The results demonstrated that although the inclusion of BBs led to increased body weight, total energy intake, and feed efficiency ratio, it did not significantly alter the overall body composition, including adiposity. Notably, BB consumption reduced total cholesterol levels, suggesting its potential to manage dyslipidemia and reduce the risk of atherosclerotic cardiovascular diseases. Furthermore, BBs significantly enhanced in the total antioxidant capacity, as indicated by the notable increase in both the total antioxidant capacity and superoxide dismutase activity. These findings provide significant insights into the promising health benefits of BBs in the context of metabolic syndrome and related health complications.
C1 [Kim, Hayoon; Kang, Sumin; Go, Gwang-woong] Hanyang Univ, Dept Food & Nutr, Seoul 04763, South Korea.
C3 Hanyang University
RP Go, GW (corresponding author), Hanyang Univ, Dept Food & Nutr, Seoul 04763, South Korea.
EM kimhayoon0408@gmail.com; sumin.kang708@gmail.com; gwgo1015@hanyang.ac.kr
RI Go, Gwang-woong/AGM-4417-2022
OI Go, Gwang-woong/0000-0002-3848-8705
FU Cuchen [202200000000711]; Cuchen Co., Ltd.
FX This research was supported by Cuchen Co., Ltd. (202200000000711).
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NR 49
TC 0
Z9 1
U1 0
U2 6
PU KOREAN SOCIETY FOOD SCIENCE & TECHNOLOGY-KOSFOST
PI SEOUL
PA #605, KOREA SCI TECHNOL CENT, 635-4 YEOKSAM-DONG, KANGNAM-GU, SEOUL,
   135-703, SOUTH KOREA
SN 1226-7708
EI 2092-6456
J9 FOOD SCI BIOTECHNOL
JI Food Sci. Biotechnol.
PD SEP
PY 2024
VL 33
IS 12
BP 2857
EP 2864
DI 10.1007/s10068-024-01533-z
EA FEB 2024
PG 8
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA D6K3Z
UT WOS:001171640100001
PM 39184995
OA Green Published
DA 2025-06-11
ER

PT S
AU Carr, RM
   Correnti, J
AF Carr, Rotonya M.
   Correnti, Jason
BE Powers, AC
   Ahima, RS
TI Insulin resistance in clinical and experimental alcoholic liver disease
SO YEAR IN DIABETES AND OBESITY
SE Annals of the New York Academy of Sciences
LA English
DT Article; Book Chapter
DE alcoholic liver disease; insulin resistance; metabolic syndrome;
   NAFLD/NASH; steatohepatitis
ID ENDOPLASMIC-RETICULUM STRESS; DIETARY SATURATED FAT; CHRONIC ETHANOL;
   PROTEIN-KINASE; METABOLIC SYNDROME; HEPATIC STEATOSIS; PROTECTIVE
   ACTION; GUT LEAKINESS; NONALCOHOLIC STEATOHEPATITIS; INTRAGASTRIC
   INFUSION
AB Alcoholic liver disease (ALD) is the number one cause of liver failure worldwide; its management costs billions of healthcare dollars annually. Since the advent of the obesity epidemic, insulin resistance (IR) and diabetes have become common clinical findings in patients with ALD; and the development of IR predicts the progression from simple steatosis to cirrhosis in ALD patients. Both clinical and experimental data implicate the impairment of several mediators of insulin signaling in ALD, and experimental data suggest that insulin-sensitizing therapies improve liver histology. This review explores the contribution of impaired insulin signaling in ALD and summarizes the current understanding of the synergistic relationship between alcohol and nutrient excess in promoting hepatic inflammation and disease.
C1 [Carr, Rotonya M.; Correnti, Jason] Univ Penn, Dept Med, Div Gastroenterol, Perelman Sch Med, Philadelphia, PA 19104 USA.
C3 University of Pennsylvania
RP Carr, RM (corresponding author), Univ Penn, Dept Med, Div Gastroenterol, Perelman Sch Med, 907 Biomed Res Bldg 2-3,421 Curie Blvd, Philadelphia, PA 19104 USA.
EM Rotonya.Carr@uphs.upenn.edu
FU NIAAA NIH HHS [K08-AA021424, K08 AA021424] Funding Source: Medline;
   NIDDK NIH HHS [P30 DK019525, P30 DK050306, P30-DK-50306] Funding Source:
   Medline
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NR 175
TC 45
Z9 48
U1 0
U2 6
PU BLACKWELL SCIENCE PUBL
PI OXFORD
PA OSNEY MEAD, OXFORD OX2 0EL, ENGLAND
SN 0077-8923
J9 ANN NY ACAD SCI
JI Ann.NY Acad.Sci.
PY 2015
VL 1353
BP 1
EP 20
DI 10.1111/nyas.12787
PG 20
WC Endocrinology & Metabolism
WE Book Citation Index – Science (BKCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA BD9TS
UT WOS:000365305100001
PM 25998863
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Uetake, Y
   Ikeda, H
   Irie, R
   Tejima, K
   Matsui, H
   Ogura, S
   Wang, H
   Mu, SY
   Hirohama, D
   Ando, K
   Sawamura, T
   Yatomi, Y
   Fujita, T
   Shimosawa, T
AF Uetake, Yuzaburo
   Ikeda, Hitoshi
   Irie, Rie
   Tejima, Kazuaki
   Matsui, Hiromitsu
   Ogura, Sayoko
   Wang, Hong
   Mu, ShengYu
   Hirohama, Daigoro
   Ando, Katsuyuki
   Sawamura, Tatsuya
   Yatomi, Yutaka
   Fujita, Toshiro
   Shimosawa, Tatsuo
TI High-salt in addition to high-fat diet may enhance inflammation and
   fibrosis in liver steatosis induced by oxidative stress and dyslipidemia
   in mice
SO LIPIDS IN HEALTH AND DISEASE
LA English
DT Article
DE High salt diet induced oxidative stress; Oxidative stress; NADPH
   oxidase; Anti-oxidant tempol; Nonalcoholic fatty liver disease
ID LOW-DENSITY-LIPOPROTEIN; NONALCOHOLIC STEATOHEPATITIS; SENSITIVE
   HYPERTENSION; INSULIN-RESISTANCE; HEPATIC STEATOSIS; FOLLOW-UP;
   VITAMIN-E; DISEASE; INJURY; OBESITY
AB Background: It is widely known that salt is an accelerating factor for the progression of metabolic syndrome and causes cardiovascular diseases, most likely due to its pro-oxidant properties. We hypothesized that excessive salt intake also facilitates the development of nonalcoholic steatohepatitis (NASH), which is frequently associated with metabolic syndrome.
   Methods: We examined the exacerbating effect of high-salt diet on high-fat diet-induced liver injury in a susceptible model to oxidative stress, apoE knockout and lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) transgenic mice.
   Results: High-salt diet led to NASH in high-fat diet-fed LOX-1 transgenic/apoE knockout mice without affecting high-fat diet-induced dyslipidemia or hepatic triglyceride accumulation. Additionally, a high-salt and high-fat diet stimulated oxidative stress production and inflammatory reaction to a greater extent than did a high-fat diet in the liver of LOX-1 transgenic/apoE knockout mice.
   Conclusions: We demonstrated that high-salt diet exacerbated NASH in high-fat diet-fed LOX-1 transgenic /apoE knockout mice and that this effect was associated with the stimulation of oxidative and inflammatory processes; this is the first study to suggest the important role of excessive salt intake in the development of NASH.
C1 [Uetake, Yuzaburo; Ogura, Sayoko; Wang, Hong; Hirohama, Daigoro; Ando, Katsuyuki; Fujita, Toshiro; Shimosawa, Tatsuo] Univ Tokyo, Grad Sch Med, Dept Nephrol & Endocrinol, Tokyo, Japan.
   [Uetake, Yuzaburo] Univ Tokyo, Grad Sch Med, Off Res Eth Support, Tokyo, Japan.
   [Ikeda, Hitoshi; Yatomi, Yutaka; Shimosawa, Tatsuo] Tokyo Univ Hosp, Clin Lab, Tokyo 113, Japan.
   [Ikeda, Hitoshi] Univ Tokyo, Grad Sch Med, Dept Gastroenterol, Tokyo, Japan.
   [Irie, Rie] Kawasaki Municipal Hosp, Dept Pathol, Kawasaki, Kanagawa, Japan.
   [Tejima, Kazuaki] Toshiba Gen Hosp, Dept Gastroenterol, Tokyo, Japan.
   [Matsui, Hiromitsu; Ogura, Sayoko] Nihon Univ, Sch Med, Fac Med, Div Lab Med,Dept Pathol & Microbiol, Tokyo, Japan.
   [Mu, ShengYu; Fujita, Toshiro] Univ Tokyo, Div Clin Epigenet, Res Ctr Adv Sci & Technol, Tokyo, Japan.
   [Sawamura, Tatsuya] Natl Cerebral & Cardiovasc Ctr Res Inst, Dept Vasc Physiol, Osaka, Japan.
   [Sawamura, Tatsuya] Shinshu Univ, Sch Med, Dept Physiol, Nagano, Japan.
C3 University of Tokyo; University of Tokyo; University of Tokyo;
   University of Tokyo; Toshiba Corporation; Nihon University; University
   of Tokyo; National Cerebral & Cardiovascular Center - Japan; Shinshu
   University
RP Shimosawa, T (corresponding author), Univ Tokyo, Grad Sch Med, Dept Nephrol & Endocrinol, Tokyo, Japan.
EM tshimo-tky@umin.ac.jp
RI Sawamura, Tatsuya/E-7103-2010
OI Hirohama, Daigoro/0000-0002-1885-1263; Yatomi,
   Yutaka/0000-0003-1719-4297
FU Grants-in-Aid for Scientific Research [26461262] Funding Source: KAKEN
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NR 36
TC 43
Z9 45
U1 3
U2 26
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1476-511X
J9 LIPIDS HEALTH DIS
JI Lipids Health Dis.
PD FEB 13
PY 2015
VL 14
AR 6
DI 10.1186/s12944-015-0002-9
PG 8
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA CC0ZI
UT WOS:000350068200001
PM 25888871
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Thomas, J
   Patel, A
   Das Sivadasan, S
   Sreevallabhan, S
   Madhavamenon, KI
   Mohanan, R
AF Thomas, Jestin
   Patel, Anand
   Das Sivadasan, Syam
   Sreevallabhan, Sheethal
   Madhavamenon, Krishnakumar Illathu
   Mohanan, Ratheesh
TI Clove bud (Syzygium aromaticum L.) polyphenol helps to mitigate
   metabolic syndrome by establishing intracellular redox homeostasis and
   glucose metabolism: A randomized, double-blinded, active-controlled
   comparative study
SO JOURNAL OF FUNCTIONAL FOODS
LA English
DT Article
DE Clove buds; Clovinol; Glutathione; Metabolic syndrome; Polyphenol; Redox
   homeostasis
ID OXIDATIVE STRESS; ORAL GLUTATHIONE; RICH EXTRACT; SUPPLEMENTATION;
   INFLAMMATION; MECHANISMS; IMMUNITY; THIOLS
AB Present randomised double-blinded comparative study investigated the influence of clove buds (Syzygium aromaticum) polyphenol extract (Clovinol) in comparison with synthetic glutathione (s-GSH) (250 mg/day for 84 days) on healthy adults (N = 70) characterised with metabolic syndrome (MetS). Outcome measures included plasma concentration of endogenous antioxidants, inflammatory markers, blood sugar and lipid metabolism markers, in addition to haematological and biochemical parameters of safety. Clovinol enhanced the plasma concentration of GSH by 6-fold and offered statistically significant enhancement in Nrf2, antioxidant enzymes and in GSH/GSSG ratio. Treatment with Clovinol also improved FBS, PPG, HbA1c, HOMA-IR and insulin levels indicating modulation of insulin resistance. Moreover, Clovinol caused significant reduction in total cholesterol, triglycerides, LDL and increased HDL, while s-GSH showed no significant effect on blood glucose and lipid metabolism. Clovinol did not show any significant side effects or toxic deviations in haematological and biochemical parameters, but significantly increased the total leukocyte and reduced neutrophil/lymphocyte ratio and inflammatory markers (IL-1 beta and TNF-alpha).
C1 [Thomas, Jestin] Leads Clin Res & Bio Serv Pvt Ltd, Bangalore 560043, India.
   [Patel, Anand] Anand Multi Special Hosp, Dept Gen Med, B Tower Sundervan Complex, Vadodara 390016, Gujarat, India.
   [Das Sivadasan, Syam; Madhavamenon, Krishnakumar Illathu] Akay Nat Ingredients, R&D Ctr, Cochin 683561, Kerala, India.
   [Sreevallabhan, Sheethal; Mohanan, Ratheesh] St Thomas Coll, Dept Biochem, Kottayam 686574, Kerala, India.
RP Mohanan, R (corresponding author), St Thomas Coll, Dept Biochem, Kottayam 686574, Kerala, India.
EM biochemistrystcp@gmail.com
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NR 46
TC 5
Z9 5
U1 0
U2 5
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1756-4646
EI 2214-9414
J9 J FUNCT FOODS
JI J. Funct. Food.
PD NOV
PY 2022
VL 98
AR 105273
DI 10.1016/j.jff.2022.105273
PG 10
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA 5Q9BW
UT WOS:000874119100003
OA gold
DA 2025-06-11
ER

PT J
AU Shakib, Z
   Shahraki, N
   Razavi, BM
   Hosseinzadeh, H
AF Shakib, Zahra
   Shahraki, Naghmeh
   Razavi, Bibi Marjan
   Hosseinzadeh, Hossein
TI Aloe vera as an herbal medicine in the treatment of metabolic
   syndrome: A review
SO PHYTOTHERAPY RESEARCH
LA English
DT Review
DE Aloe barbadensis; Aloe vera; diabetes mellitus; dyslipidemia;
   hypertension; metabolic syndrome; obesity
ID LEAF GEL; DIABETES-MELLITUS; FAT MASS; BARBADENSIS; EMODIN; L.; EXTRACT;
   OBESITY; PLANTS; CONSTITUENTS
AB Metabolic syndrome (MS) is a highly prevalent health problem worldwide and is associated with different risk factors, including hyperglycemia, dyslipidemia, hypertension, and obesity. This condition increases the risk of developing type II diabetes mellitus and cardiovascular problems. The MS is one of the most important health concerns in industrialized countries and mainly results from a sedentary lifestyle, high levels of subjective stress, and unhealthy diets. Nowadays, the identification of appropriate health care approaches, such as herbal medicines, with fewer side effects is more favorable, especially with regard to the adverse effects of chemical drugs. Aloe barbadensis Miller known as Aloe vera is a useful plant with two major parts, including leaves that contain high concentrations of anthraquinone compounds and a clear gel. The gel is used as a food with several beneficial properties, such as antiinflammatory, antioxidant, antiviral, antibacterial, and wound-healing features. Other effects of A. vera, such as its lipid-lowering, antihypertensive, antidiabetic, antiobesity, and cardioprotective impacts, have been demonstrated in several studies. The present study was conducted to review the evidence on the pharmacological effects of A. vera on the different components of MS.
C1 [Shakib, Zahra; Shahraki, Naghmeh] Mashhad Univ Med Sci, Sch Pharm, Mashhad, Razavi Khorasan, Iran.
   [Razavi, Bibi Marjan] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Targeted Drug Delivery Res Ctr, Mashhad, Razavi Khorasan, Iran.
   [Hosseinzadeh, Hossein] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Pharmaceut Res Ctr, Mashhad, Razavi Khorasan, Iran.
   [Razavi, Bibi Marjan; Hosseinzadeh, Hossein] Mashhad Univ Med Sci, Sch Pharm, Dept Pharmacodynam & Toxicol, Mashhad, Razavi Khorasan, Iran.
C3 Mashhad University of Medical Sciences; Mashhad University of Medical
   Sciences; Mashhad University of Medical Sciences; Mashhad University of
   Medical Sciences
RP Hosseinzadeh, H (corresponding author), Mashhad Univ Med Sci, Pharmaceut Technol Inst, Pharmaceut Res Ctr, Mashhad, Razavi Khorasan, Iran.
EM hosseinzadehh@mums.ac.ir
RI razavi, Bibi Marjan/AAY-5636-2020; Hosseinzadeh, Hossein/F-3013-2010
OI razavi, Bibi Marjan/0000-0002-7450-9286; Hosseinzadeh,
   Hossein/0000-0002-3483-851X
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NR 74
TC 64
Z9 65
U1 0
U2 40
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0951-418X
EI 1099-1573
J9 PHYTOTHER RES
JI Phytother. Res.
PD OCT
PY 2019
VL 33
IS 10
BP 2649
EP 2660
DI 10.1002/ptr.6465
EA AUG 2019
PG 12
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA JD9FA
UT WOS:000484098300001
PM 31456283
DA 2025-06-11
ER

PT J
AU Armani, A
   Berry, A
   Cirulli, F
   Caprio, M
AF Armani, Andrea
   Berry, Alessandra
   Cirulli, Francesca
   Caprio, Massimiliano
TI Molecular mechanisms underlying metabolic syndrome: the expanding role
   of the adipocyte
SO FASEB JOURNAL
LA English
DT Review
DE adipose tissue; browning; aging; caloric restriction; obesity
ID BROWN ADIPOSE-TISSUE; HIGH-FAT-DIET; ACTIVATED PROTEIN-KINASE;
   WHOLE-BODY GLUCOSE; INSULIN-RESISTANCE; MINERALOCORTICOID RECEPTOR;
   LIFE-SPAN; CALORIE RESTRICTION; OXIDATIVE STRESS; VISCERAL FAT
AB The metabolic syndrome (MetS) is defined as a cluster of 3 or more metabolic and cardiovascular risk factors and represents a serious problem for public health. Altered function of adipose tissue has a significant impact on whole-body metabolism and represents a key driver for the development of these metabolic derangements, collectively referred as to MetS. In particular, increased visceral and ectopic fat deposition play a major role in the development of insulin resistance and MetS. A large body of evidence demonstrates that aging and MetS share several metabolic alterations. Of importance, molecular pathways that regulate lifespan affect key processes of adipose tissue physiology, and transgenic mouse models with adipose-specific alterations in these pathways show derangements of adipose tissue and other metabolic features of MetS, which highlights a causal link between dysfunctional adipose tissue and deleterious effects on whole-body homeostasis. This review analyzes adipose tissue-specific dysfunctions, including metabolic alterations that are related to aging, that have a significant impact on the development of MetS.-Armani, A., Berry, A., Cirulli, F., Caprio, M. Molecular mechanisms underlying metabolic syndrome: the expanding role of the adipocyte.
C1 [Armani, Andrea; Caprio, Massimiliano] Ist Ricovero & Cura Carattere Sci San Raffaele Pi, Lab Cardiovasc Endocrinol, Via Val Cannuta 247, I-00166 Rome, Italy.
   [Berry, Alessandra; Cirulli, Francesca] Ist Super Sanita, Ctr Behav Sci & Mental Hlth, Rome, Italy.
   [Caprio, Massimiliano] San Raffaele Roma Open Univ, Dept Human Sci & Promot Qual Life, Rome, Italy.
C3 Istituto Superiore di Sanita (ISS)
RP Caprio, M (corresponding author), Ist Ricovero & Cura Carattere Sci San Raffaele Pi, Lab Cardiovasc Endocrinol, Via Val Cannuta 247, I-00166 Rome, Italy.
EM massimiliano.caprio@sanraffaele.it
RI Cirulli, Francesca/H-5992-2019; Berry, Alessandra/N-9280-2017; Armani,
   Andrea/AAC-2071-2022; Caprio, Massimiliano/J-3020-2012
OI ARMANI, Andrea/0000-0002-2130-1596; CIRULLI,
   Francesca/0000-0001-9440-1873; Caprio, Massimiliano/0000-0003-0722-7163;
   Berry, Alessandra/0000-0001-6562-9043
FU Ministero della Salute (Progetti Collaborazione Ricercatori Italiani
   all'Estero) [PE-2011-02347070]; Ministero della Salute (Project H2020
   AwE) [633589]
FX This work was supported by the Ministero della Salute (Bando
   2011-2012,Progetti Collaborazione Ricercatori Italiani all'Estero;
   Project Grant PE-2011-02347070 to M.C., and Project H2020 AwE, Grant
   Agreement 633589 to F.C.). The authors acknowledge networking support by
   the European Cooperation in Science and Technology (COST) Action
   Aldosterone and Mineralocorticoid Receptor (ADMIRE) BM1301. The authors
   thank Uberto Pagotto (Alma Mater University of Bologna, Bologna, Italy)
   and Elisa Fabbrini (The Janssen Pharmaceutical Companies of Johnson &
   Johnson) for critical review of the manuscript, and Morag J. Young
   (Centre for Endocrinology and Metabolism, Hudson Institute of Medical
   Research, Clayton, VIC, Australia) for English editing. The authors
   declare no conflicts of interest.
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NR 196
TC 56
Z9 57
U1 0
U2 20
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0892-6638
EI 1530-6860
J9 FASEB J
JI Faseb J.
PD OCT
PY 2017
VL 31
IS 10
BP 4240
EP 4255
DI 10.1096/fj.201601125RRR
PG 16
WC Biochemistry & Molecular Biology; Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA FK3PF
UT WOS:000413397400005
PM 28705812
DA 2025-06-11
ER

PT J
AU Keita, AD
   Judd, SE
   Howard, VJ
   Carson, AP
   Ard, JD
   Fernandez, JR
AF Keita, Akilah Dulin
   Judd, Suzanne E.
   Howard, Virginia J.
   Carson, April P.
   Ard, Jamy D.
   Fernandez, Jose R.
TI Associations of neighborhood area level deprivation with the metabolic
   syndrome and inflammation among middle- and older- age adults
SO BMC PUBLIC HEALTH
LA English
DT Article
DE Neighborhoods; Socioeconomic factors; Metabolic syndrome; Cardiovascular
   disease
ID DISEASE RISK-FACTORS; CARDIOVASCULAR-DISEASE; SOCIOECONOMIC-STATUS;
   PERCEIVED STRESS; US ADULTS; HEALTH; HEART; ATHEROSCLEROSIS; COHORT;
   STROKE
AB Background: The study examines the association of neighborhood socioeconomic deprivation and metabolic syndrome with inflammation.
   Methods: The analysis included 19, 079 black and white participants from the REasons for Geographic And Racial Differences in Stroke Study who were age > 45 years at baseline. Logistic regression examined whether neighborhood deprivation was associated with increased odds of METS and CRP-MetS.
   Results: Among black adults, residing in the most deprived neighborhoods was associated with increased odds of obesity (p < .01), lower HDL (p < .001), high blood pressure (p < .01), elevated fasting glucose (p < .001), inflammation (p < .01), and CRP-MetS (p < .001). Among white adults, neighborhood deprivation was associated with higher waist circumference (p < .001), lower HDL (p < .001), higher triglycerides (p < .01), higher glucose (p < .001), higher BMI (p < .0001), higher blood pressure (p = .01), METS (p < .001), inflammation (p < .01) and CRP-MetS (p < .001).
   Conclusions: These findings highlight the role of neighborhood socioeconomic deprivation on METS and CRP-MetS for black and white adults. Interventions tailored to address the contextual effects of deprived neighborhoods may reduce the observed neighborhood disparities.
C1 [Keita, Akilah Dulin] Brown Univ, Inst Community Hlth Promot, Providence, RI 02912 USA.
   [Judd, Suzanne E.] Univ Alabama Birmingham, Dept Biostat, Birmingham, AL 35205 USA.
   [Howard, Virginia J.; Carson, April P.] Univ Alabama Birmingham, Dept Epidemiol, Birmingham, AL 35205 USA.
   [Ard, Jamy D.] Wake Forest Sch Med, Dept Epidemiol & Prevent, Winston Salem, NC USA.
   [Fernandez, Jose R.] Univ Alabama Birmingham, Dept Nutr Sci, Birmingham, AL 35205 USA.
C3 Brown University; University of Alabama System; University of Alabama
   Birmingham; University of Alabama System; University of Alabama
   Birmingham; Wake Forest University; University of Alabama System;
   University of Alabama Birmingham
RP Keita, AD (corresponding author), Brown Univ, Inst Community Hlth Promot, Box G-S121-8, Providence, RI 02912 USA.
EM akilah_keita@brown.edu
OI Howard, Virginia/0000-0003-4912-9975; Carson, April/0000-0002-7970-6756;
   Ard, Jamy/0000-0002-1643-6795
FU National Institutes of Health
FX National Institutes of Health.
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NR 43
TC 66
Z9 74
U1 0
U2 15
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1471-2458
J9 BMC PUBLIC HEALTH
JI BMC Public Health
PD DEC 23
PY 2014
VL 14
AR 1319
DI 10.1186/1471-2458-14-1319
PG 9
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA CA0LS
UT WOS:000348609900001
PM 25539758
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Akhavanfar, R
   Hojati, A
   Kahrizi, MS
   Farhangi, MA
   Ardekani, AM
AF Akhavanfar, Roozbeh
   Hojati, Ali
   Kahrizi, Mohammad Saeed
   Farhangi, Mahdieh Abbasalizad
   Ardekani, Abnoos Mokhtari
TI RETRACTED: Adherence to lifelines diet score and risk factors of
   metabolic syndrome among overweight and obese adults: A cross-sectional
   study (Retracted Article)
SO FRONTIERS IN NUTRITION
LA English
DT Article; Retracted Publication
DE lifeline diet score; metabolic syndivme; obesity; diabetes;
   cardiovascular diseae
ID HEALTHY EATING INDEX; BLOOD-PRESSURE; OXIDATIVE STRESS; MEDITERRANEAN
   DIET; RELATIVE VALIDITY; PHYSICAL-ACTIVITY; WHOLE GRAINS; QUALITY;
   HYPERTENSION; FRUIT
AB BackgroundMetabolic syndrome (MetS) is one of the most significant public health issues worldwide, and diet quality is an important controllable environmental factor influencing the incidence of MetS. Numerous dietary scores have been established to assess compliance with dietary recommendations or eating patterns, many of which are not entirely food-based. Hence, Lifelines Diet Score (LLDS) was developed in response to the shortcomings of existing tools. This study aimed to assess any possible links between total food quality and cardiometabolic risk factors among overweight and obese adults. MethodsThis cross-sectional study included 338 overweight and obese individuals [body mass index (BMI) > 25 kg/m(2)] aged 20-50 years in Tabriz, Iran. To collect dietary data, we used a validated semi-quantitative Food Frequency Questionnaire (FFQ) for Iranian population. Enzymatic-colorimetric methods were used to assess serum glucose and lipids, and enzyme-linked immunosorbent assay (ELISA) kits were used to measure insulin levels. In addition, the Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) and Quantitative Insulin Sensitivity Check Index (QUICKI) were calculated. ResultsBMI and hip circumference (HC) were significantly different (P < 0.05) amongst LLDS tertiles. Adherence to the highest tertile of LLDS was associated with lower SBP, and the subjects in higher LLDS tertiles significantly had lower systolic blood pressure (SBP) (P = 0.04). Triglyceride (TG) levels were also lower in the third tertile of LLDS with a near-significant P-value (P = 0.05). ConclusionAccording to our results, a higher diet quality score, determined by LLDS, can be associated with a lower risk of MetS. Further experimental and longitudinal studies are needed to better understand this relationship.
C1 [Akhavanfar, Roozbeh] Isfahan Univ Med Sci, Sch Med, Esfahan, Iran.
   [Hojati, Ali] Tabriz Univ Med Sci, Fac Nutr, Dept Community Nutr, Tabriz, Iran.
   [Kahrizi, Mohammad Saeed] Alborz Univ Med Sci, Karaj, Iran.
   [Farhangi, Mahdieh Abbasalizad] Tabriz Univ Med Sci, Tabriz Hlth Serv Management Res Ctr, Tabriz, Iran.
   [Ardekani, Abnoos Mokhtari] Kerman Univ Med Sci, Inst Basic & Clin Physiol Sci, Endocrinoligy & Metab Res Ctr, Kerman, Iran.
   [Ardekani, Abnoos Mokhtari] Kerman Univ Med Sci, Physiol Res Ctr, Kerman, Iran.
C3 Isfahan University of Medical Sciences; Tabriz University of Medical
   Science; Alborz University of Medical Sciences; Tabriz University of
   Medical Science; Kerman University of Medical Sciences; Kerman
   University of Medical Sciences
RP Farhangi, MA (corresponding author), Tabriz Univ Med Sci, Tabriz Hlth Serv Management Res Ctr, Tabriz, Iran.; Ardekani, AM (corresponding author), Kerman Univ Med Sci, Inst Basic & Clin Physiol Sci, Endocrinoligy & Metab Res Ctr, Kerman, Iran.; Ardekani, AM (corresponding author), Kerman Univ Med Sci, Physiol Res Ctr, Kerman, Iran.
EM abbasalizad_m@yahoo.com; amokhtari@kmu.ac.ir
RI Farhangi, Mahdieh/AAC-6758-2019; Kahrizi, Mohammad saeed/GOE-4170-2022;
   Mokhtari, Abnoos/GYV-5829-2022
FU Tabriz University of Medical Sciences;  [70010]
FX Funding This study received a grant from the Vice Chancellor for
   Research and Technology, Tabriz University of Medical Sciences, Iran
   (Identifier: IR.TBZMED.REC.1401.444; Grant No. 70010).
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NR 78
TC 9
Z9 9
U1 1
U2 7
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD NOV 17
PY 2022
VL 9
AR 961468
DI 10.3389/fnut.2022.961468
PG 13
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 6S0DP
UT WOS:000892668200001
PM 36466413
OA Green Published, gold
DA 2025-06-11
ER

EF﻿FN Clarivate Analytics Web of Science
VR 1.0
PT J
AU Janus, A
   Szahidewicz-Krupska, E
   Mazur, G
   Doroszko, A
AF Janus, A.
   Szahidewicz-Krupska, E.
   Mazur, G.
   Doroszko, A.
TI Insulin Resistance and Endothelial Dysfunction Constitute a Common
   Therapeutic Target in Cardiometabolic Disorders
SO MEDIATORS OF INFLAMMATION
LA English
DT Review
ID TYPE-2 DIABETES-MELLITUS; ANGIOTENSIN-ALDOSTERONE SYSTEM; NITRIC-OXIDE
   SYNTHASE; PROTEIN-KINASE-C; MEDITERRANEAN DIET; OXIDATIVE STRESS;
   KAPPA-B; CARDIOVASCULAR RISK; ADIPOSE-TISSUE; GLUCOSE-UPTAKE
AB Insulin resistance and other risk factors for atherosclerosis, such as hypertension and hypercholesterolemia, promote endothelial dysfunction and lead to development of metabolic syndrome which constitutes an introduction to cardiovascular disease. The insulin resistance and endothelial dysfunction cross talk between each other by numerous metabolic pathways. Hence, targeting one of these pathologies with pleiotropic treatment exerts beneficial effect on another one. Combined and expletive treatment of hypertension, lipid disorders, and insulin resistance with nonpharmacological interventions and conventional pharmacotherapy may inhibit the transformation of metabolic disturbances to fully developed cardiovascular disease. This paper summarises the common therapeutic targets for insulin resistance, endothelial dysfunction, and vascular inflammatory reaction at molecular level and analyses the potential pleiotropic effects of drugs used currently in management of cardiovascular disease, metabolic syndrome, and diabetes.
C1 [Janus, A.; Szahidewicz-Krupska, E.; Mazur, G.; Doroszko, A.] Wroclaw Med Univ, Dept Internal Med Occupat Dis Hypertens & Clin On, Ulica Borowska 213, PL-50556 Wroclaw, Poland.
   [Janus, A.; Szahidewicz-Krupska, E.; Doroszko, A.] Integrated Cardiovasc Ctr Prov Specialist Hosp Wr, Res & Dev Dept, Ulica Kamienskiego 73A, PL-51124 Wroclaw, Poland.
C3 Wroclaw Medical University
RP Doroszko, A (corresponding author), Wroclaw Med Univ, Dept Internal Med Occupat Dis Hypertens & Clin On, Ulica Borowska 213, PL-50556 Wroclaw, Poland.; Doroszko, A (corresponding author), Integrated Cardiovasc Ctr Prov Specialist Hosp Wr, Res & Dev Dept, Ulica Kamienskiego 73A, PL-51124 Wroclaw, Poland.
EM adrian.doroszko@gmail.com
RI Janus, Agnieszka/E-7810-2016; Doroszko, Adrian/JJG-1097-2023
OI Doroszko, Adrian/0000-0001-5472-028X; Mazur,
   Grzegorz/0000-0001-6610-2008; Szahidewicz-Krupska,
   Ewa/0000-0002-4446-6991
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NR 92
TC 176
Z9 184
U1 0
U2 9
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0962-9351
EI 1466-1861
J9 MEDIAT INFLAMM
JI Mediat. Inflamm.
PY 2016
VL 2016
AR 3634948
DI 10.1155/2016/3634948
PG 10
WC Cell Biology; Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Immunology
GA DQ2SQ
UT WOS:000379053700001
PM 27413253
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Dudzinska, D
   Boncler, M
   Watala, C
AF Dudzinska, Dominika
   Boncler, Magdalena
   Watala, Cezary
TI The cardioprotective power of leaves
SO ARCHIVES OF MEDICAL SCIENCE
LA English
DT Article
DE anti-oxidants; cardiovascular diseases; leaf extracts; polyphenols
ID GINKGO-BILOBA EXTRACT; BLOOD-PLATELET ADHESION; NETTLE URTICA-DIOICA;
   MORUS-ALBA L.; GREEN TEA; ANTIOXIDANT ACTIVITY; WITHANIA-SOMNIFERA;
   METABOLIC SYNDROME; PLANT-EXTRACTS; LEAF EXTRACT
AB Lack of physical activity, smoking and/or inappropriate diet can contribute to the increase of oxidative stress, in turn affecting the pathophysiology of cardiovascular diseases. Strong anti-oxidant properties of plant polyphenolic compounds might underlie their cardioprotective activity. This paper reviews recent findings on the anti-oxidant activity of plant leaf extracts and emphasizes their effects on blood platelets, leukocytes and endothelial cells - the targets orchestrating the development and progression of cardiovascular diseases. We also review the evidence linking supplementation with plant leaf extracts and the risk factors defining the metabolic syndrome. The data point to the importance of leaves as an alternative source of polyphenolic compounds in the human diet and their role in the prevention of cardiovascular diseases.
C1 [Dudzinska, Dominika; Boncler, Magdalena; Watala, Cezary] Med Univ Lodz, Dept Haemostasis & Haemostat Disorders, PL-92215 Lodz, Poland.
C3 Medical University Lodz
RP Dudzinska, D (corresponding author), Med Univ Lodz, Dept Haemostasis & Haemostat Disorders, Chair Biomed Sci, 6-8 Mazowiecka St, PL-92215 Lodz, Poland.
EM dom.dudzinska@gmail.com
RI Watala, Cezary/ABF-4863-2020; BONCLER, MAGDALENA/S-9252-2016; Dudzińska,
   Dominika/D-3693-2015
OI BONCLER, MAGDALENA/0000-0002-4860-5338
FU project "FLAWO-PIRYNA" - European Regional Development Fund within the
   framework of the Innovative Economy Programme
   [UDA-POIG.01.03.01-10-129/08-00]
FX This work was supported by the project "FLAWO-PIRYNA",
   UDA-POIG.01.03.01-10-129/08-00, financed by the European Regional
   Development Fund within the framework of the Innovative Economy
   Programme 2007-2013.
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NR 142
TC 11
Z9 12
U1 0
U2 12
PU TERMEDIA PUBLISHING HOUSE LTD
PI POZNAN
PA KLEEBERGA 2, POZNAN, 61-615, POLAND
SN 1734-1922
EI 1896-9151
J9 ARCH MED SCI
JI Arch. Med. Sci.
PY 2015
VL 11
IS 4
BP 819
EP 839
DI 10.5114/aoms.2015.53303
PG 21
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA CO9HG
UT WOS:000359484900016
PM 26322095
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Stahl, EP
   Dhindsa, DS
   Lee, SK
   Sandesara, PB
   Chalasani, NP
   Sperling, LS
AF Stahl, Eric P.
   Dhindsa, Devinder S.
   Lee, Suegene K.
   Sandesara, Pratik B.
   Chalasani, Naga P.
   Sperling, Laurence S.
TI Nonalcoholic Fatty Liver Disease and the Heart JACC
   State-of-the-Art Review
SO JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
LA English
DT Review
DE cardiovascular disease; metabolic syndrome; nonalcoholic fatty liver
   disease
ID GAMMA-GLUTAMYL-TRANSFERASE; 3RD NATIONAL-HEALTH; CARDIOVASCULAR-DISEASE;
   HEPATIC STEATOSIS; VITAMIN-E; BARIATRIC SURGERY; WEIGHT-LOSS; ALANINE
   AMINOTRANSFERASE; ENDOTHELIAL DYSFUNCTION; INCREASED PREVALENCE
AB Nonalcoholic fatty liver disease (NAFLD) and cardiovascular disease (CVD) are both manifestations of end-organ damage of the metabolic syndrome. Through multiple pathophysiological mechanisms, CVD and NAFLD are associated with each other. Systemic inflammation, endothelial dysfunction, hepatic insulin resistance, oxidative stress, and altered lipid metabolismare some of the mechanisms by which NAFLD increases the risk of CVD. Patients with NAFLD develop increased atherosclerosis, cardiomyopathy, and arrhythmia, which clinically result in cardiovascular morbidity and mortality. Defining the mechanisms linking these 2 diseases offers the opportunity to further develop targeted therapies. The aim of this comprehensive review is to examine the association between CVD and NAFLD and discuss the overlapping management approaches.
RP Sperling, LS (corresponding author), Emory Univ, Sch Med, Emory Heart Dis Prevent Ctr, 1365 Clifton Rd NE,Bldg A,Suite 2200, Atlanta, GA 30322 USA.
EM lsperli@emory.edu
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NR 168
TC 295
Z9 305
U1 3
U2 28
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0735-1097
EI 1558-3597
J9 J AM COLL CARDIOL
JI J. Am. Coll. Cardiol.
PD MAR 5
PY 2019
VL 73
IS 8
BP 949
EP 963
PG 15
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA HN0IV
UT WOS:000459872000012
PM 30819364
HC Y
HP N
DA 2025-06-11
ER

PT J
AU da Silva, FC
   Hernandez, SSS
   Gonçalves, E
   Arancibia, BAV
   Castro, TLD
   Da Silva, R
AF da Silva, Franciele Cascaes
   Soleman Hernandez, Salma Stephany
   Goncalves, Elizandra
   Valdivia Arancibia, Beatriz Angelica
   Da Silva Castro, Thiago Luis
   Da Silva, Rudney
TI Anthropometric indicators of obesity in policemen: A systematic review
   of observational studies
SO INTERNATIONAL JOURNAL OF OCCUPATIONAL MEDICINE AND ENVIRONMENTAL HEALTH
LA English
DT Review
DE Obesity; Police; Systematic review; Observational study
ID HEART-DISEASE RISK; LONG WORK HOURS; METABOLIC SYNDROME; OXIDATIVE
   STRESS; PHYSICAL-ACTIVITY; OFFICERS; ADIPOSITY; FITNESS; COHORT; IMPACT
AB The aim of this paper was to summarize scientific literature on obesity in policemen through a systematic review of observational studies. For this purpose the following electronic databases were selected: Medline by Pubmed, CINAHL, and Scopus; and a manual search of the referenced studies concerning this topic was performed. There were no restrictions with respect to the year or language of the publication. Twenty-three studies were identified and 9 articles, considered as potentially relevant, were included. The labor time, shift and career progression promoted changes in body composition. Most of the policemen taking part in the studies included in this paper were overweight (BMI: 25.2-29.3), obese (body fat a parts per thousand yen 25%), had increased waist (90.4-102 cm) and abdominal perimeters (18.9-90.5 cm), and had a higher risk of chronic disease, which is associated with depression and stress development. Interventional studies are needed for the purpose of proposing preventive and rehabilitation programs, which would result in providing physical and mental well-being, improvement of life quality and, especially, prevention of obesity related to police work.
C1 [da Silva, Franciele Cascaes; Soleman Hernandez, Salma Stephany; Goncalves, Elizandra; Valdivia Arancibia, Beatriz Angelica; Da Silva Castro, Thiago Luis; Da Silva, Rudney] Univ Estado Santa Catarina, Ctr Hlth Sci & Sports, Adapted Phys Act Lab, BR-88080350 Florianopolis, SC, Brazil.
C3 Universidade do Estado de Santa Catarina
RP da Silva, FC (corresponding author), Univ Estado Santa Catarina, Ctr Hlth Sci & Sports, Adapted Phys Act Lab, Pascoal Simone St 358, BR-88080350 Florianopolis, SC, Brazil.
EM francascaes@yahoo.com.br
RI Silva, Rudney/C-3189-2017
OI Silva, Rudney/0000-0002-9386-0039
FU Foundation for Research and Innovation in the State of Santa Catarina
   (FAPESC) [13.680/2011-8]
FX Foundation for Research and Innovation in the State of Santa Catarina
   (FAPESC) under protocol 13.680/2011-8.
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NR 37
TC 19
Z9 22
U1 0
U2 16
PU NOFER INST OCCUPATIONAL MEDICINE, POLAND
PI LODZ
PA SW TERESY 8, LODZ, 91-348, POLAND
SN 1232-1087
EI 1896-494X
J9 INT J OCCUP MED ENV
JI Int. J. Occup. Med. Environ. Health
PD DEC
PY 2014
VL 27
IS 6
BP 891
EP 901
DI 10.2478/s13382-014-0318-0
PG 11
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA AY6ND
UT WOS:000347682000002
PM 25503888
OA gold
DA 2025-06-11
ER

PT J
AU Aprea, G
   Del Matto, I
   Tucci, P
   Marino, L
   Scattolini, S
   Rossi, F
AF Aprea, Giuseppe
   Del Matto, Ilaria
   Tucci, Patrizia
   Marino, Lucio
   Scattolini, Silvia
   Rossi, Franca
TI In Vivo Functional Properties of Dairy Bacteria
SO MICROORGANISMS
LA English
DT Review
DE dairy microorganisms; SLAB; NSLAB; propionibacteria; minor species; in
   vivo studies
ID ORIGINATED PROBIOTIC BACTERIUM; LACTOBACILLUS-CASEI ZHANG; INTESTINAL
   MICROBIOTA; INNER-MONGOLIA; CANCER-CELLS; PLANTARUM; CHEESE; VITRO;
   FREUDENREICHII; MECHANISMS
AB This literature review aimed to collect investigations on the in vivo evidence for bacteria associated with fermented dairy foods to behave as probiotics with beneficial effects in the prevention and treatment of various diseases. All main bacterial groups commonly present in high numbers in fermented milks or cheeses were taken into account, namely starter lactic acid bacteria (SLAB) Lactobacillus delbrueckii subsp. bulgaricus and lactis, L. helveticus, Lactococcus lactis, Streptococcus thermophilus, non-starter LAB (NSLAB) Lacticaseibacillus spp., Lactiplantibacillus plantarum, dairy propionibacteria, and other less frequently encountered species. Only studies regarding strains of proven dairy origin were considered. Studies in animal models and clinical studies showed that dairy bacteria ameliorate symptoms of inflammatory bowel disease (IBD), mucositis, metabolic syndrome, aging and oxidative stress, cancer, bone diseases, atopic dermatitis, allergies, infections and damage caused by pollutants, mild stress, and depression. Immunomodulation and changes in the intestinal microbiota were the mechanisms most often involved in the observed effects. The results of the studies considered indicated that milk and dairy products are a rich source of beneficial bacteria that should be further exploited to the advantage of human and animal health.
C1 [Aprea, Giuseppe; Del Matto, Ilaria; Tucci, Patrizia; Marino, Lucio; Scattolini, Silvia; Rossi, Franca] Ist Zooprofilatt Sperimentale Abruzzo & Molise G C, Campo Boario, I-64100 Teramo, Italy.
RP Rossi, F (corresponding author), Ist Zooprofilatt Sperimentale Abruzzo & Molise G C, Campo Boario, I-64100 Teramo, Italy.
EM g.aprea@izs.it; i.delmatto@izs.it; p.tucci@izs.it; l.marino@izs.it;
   s.scattolini@izs.it; f.rossi@izs.it
RI Del Matto, Ilaria/AAS-5512-2021; Scattolini, Silvia/A-6023-2016; Rossi,
   Franca/X-8036-2018; Tucci, Patrizia/J-2683-2016; Aprea,
   Giuseppe/C-1057-2017
OI Rossi, Franca/0000-0002-7443-1538; Del Matto,
   Ilaria/0000-0002-9805-3711; Tucci, Patrizia/0000-0002-7051-8505; Aprea,
   Giuseppe/0000-0003-4783-3432; Marino, Lucio/0000-0002-3002-1609
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NR 108
TC 7
Z9 7
U1 6
U2 35
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-2607
J9 MICROORGANISMS
JI Microorganisms
PD JUL
PY 2023
VL 11
IS 7
AR 1787
DI 10.3390/microorganisms11071787
PG 33
WC Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Microbiology
GA N3XI5
UT WOS:001036376700001
PM 37512959
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Liu, K
   Luo, M
   Wei, S
AF Liu, Kui
   Luo, Miao
   Wei, Shuang
TI The Bioprotective Effects of Polyphenols on Metabolic Syndrome against
   Oxidative Stress: Evidences and Perspectives
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Review
ID FATTY LIVER-DISEASE; DENSITY-LIPOPROTEIN CHOLESTEROL; CARDIOVASCULAR
   RISK-FACTORS; GREEN TEA EXTRACT; ANTIOXIDANT ACTIVITY; BLOOD-PRESSURE;
   DOUBLE-BLIND; IN-VITRO; RESVERATROL SUPPLEMENTATION; SERUM-LIPIDS
AB Polyphenols are the general designation of various kinds of phytochemicals, mainly classified as flavonoids and nonflavonoids. Polyphenolic compounds have been confirmed to exhibit numerous bioactivities and potential health benefits both in vivo and in vitro. Dietary polyphenols have been shown to significantly alleviate several manifestations of metabolic syndrome, namely, central obesity, hypertension, dyslipidemia, and high blood sugar. This review is aimed at discussing the bioprotective effects and related molecular mechanisms of polyphenols, mainly by increasing antioxidant capacity or oxygen scavenging capacity. Polyphenols can exert their antioxidative activity by balancing the organic oxidoreductase enzyme system, regulating antioxidant responsive signaling pathways, and restoring mitochondrial function. These data are helpful for providing new insights into the potential biological effects of polyphenolic compounds and the development of future antioxidant therapeutics.
C1 [Liu, Kui; Luo, Miao; Wei, Shuang] Huazhong Univ Sci & Technol, Tongji Med Coll, Hlth Minist, Key Lab Pulm Dis,Dept Resp & Crit Care Med,Tongji, Wuhan 430030, Hubei, Peoples R China.
C3 Huazhong University of Science & Technology
RP Wei, S (corresponding author), Huazhong Univ Sci & Technol, Tongji Med Coll, Hlth Minist, Key Lab Pulm Dis,Dept Resp & Crit Care Med,Tongji, Wuhan 430030, Hubei, Peoples R China.
EM wsdavid2001@163.com
RI Wei, Shuang/HSC-2591-2023
OI Luo, Miao/0000-0002-6474-7205; Wei, Shuang/0000-0001-5322-9667
FU National Natural Science Foundation of China [81772477, 81201848]
FX This work was supported by funding from the National Natural Science
   Foundation of China (No.81772477 and No. 81201848) awarded to Dr. Shuang
   Wei.
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NR 112
TC 82
Z9 84
U1 2
U2 32
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PD NOV 30
PY 2019
VL 2019
AR 6713194
DI 10.1155/2019/6713194
PG 16
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA JU6DG
UT WOS:000501764600002
PM 31885810
OA Green Published
DA 2025-06-11
ER

PT J
AU Guo, B
   Zhuang, TT
   Xu, F
   Lin, X
   Li, FXZ
   Shan, SK
   Wu, F
   Zhong, JY
   Wang, Y
   Zheng, MH
   Xu, QS
   Ehsan, UMH
   Yuan, LQ
AF Guo, Bei
   Zhuang, Tongtian
   Xu, Feng
   Lin, Xiao
   Li, Fuxingzi
   Shan, Su-Kang
   Wu, Feng
   Zhong, Jia-Yu
   Wang, Yi
   Zheng, Ming-Hui
   Xu, Qiu-Shuang
   Ehsan, Ullah Muhammad Hasnain
   Yuan, Ling-Qing
TI New Insights Into Implications of CTRP3 in Obesity, Metabolic
   Dysfunction, and Cardiovascular Diseases: Potential of Therapeutic
   Interventions
SO FRONTIERS IN PHYSIOLOGY
LA English
DT Review
DE adipocytokines; CTRP3; insulin resistance; therapeutic targets; type 2
   diabetes mellitus; obesity; metabolic syndrome; cardiovascular disorders
ID FACTOR-RELATED PROTEIN-3; REPEAT-CONTAINING SEQUENCE; MUSCLE-CELL
   CALCIFICATION; C1Q/TNF-RELATED PROTEIN-3; ADIPOSE-TISSUE; COLLAGENOUS
   REPEAT; OXIDATIVE STRESS; ADIPONECTIN MULTIMERIZATION; CHROMOSOMAL
   LOCALIZATION; PROMOTES PROLIFERATION
AB Adipose tissue, as the largest endocrine organ, secretes many biologically active molecules circulating in the bloodstream, collectively termed adipocytokines, which not only regulate the metabolism but also play a role in pathophysiological processes. C1q tumor necrosis factor (TNF)-related protein 3 (CTRP3) is a member of C1q tumor necrosis factor-related proteins (CTRPs), which is a paralog of adiponectin. CTRP3 has a wide range of effects on glucose/lipid metabolism, inflammation, and contributes to cardiovascular protection. In this review, we comprehensively discussed the latest research on CTRP3 in obesity, diabetes, metabolic syndrome, and cardiovascular diseases.
C1 [Guo, Bei; Xu, Feng; Li, Fuxingzi; Shan, Su-Kang; Zhong, Jia-Yu; Wang, Yi; Zheng, Ming-Hui; Xu, Qiu-Shuang; Ehsan, Ullah Muhammad Hasnain; Yuan, Ling-Qing] Cent South Univ, Natl Clin Res Ctr Metab Dis, Hunan Prov Key Lab Metab Bone Dis, Xiangya Hosp 2, Changsha, Peoples R China.
   [Guo, Bei; Xu, Feng; Li, Fuxingzi; Shan, Su-Kang; Zhong, Jia-Yu; Wang, Yi; Zheng, Ming-Hui; Xu, Qiu-Shuang; Ehsan, Ullah Muhammad Hasnain; Yuan, Ling-Qing] Cent South Univ, Xiangya Hosp 2, Dept Endocrinol & Metab, Changsha, Peoples R China.
   [Zhuang, Tongtian] Fourth Mil Med Univ, Xijing Hosp, Dept Dermatol, Xian, Peoples R China.
   [Lin, Xiao] Cent South Univ, Dept Radiol, Xiangya Hosp 2, Changsha, Peoples R China.
   [Wu, Feng] Cent South Univ, Dept Pathol, Xiangya Hosp 2, Changsha, Peoples R China.
C3 Central South University; Central South University; Air Force Medical
   University; Central South University; Central South University
RP Yuan, LQ (corresponding author), Cent South Univ, Natl Clin Res Ctr Metab Dis, Hunan Prov Key Lab Metab Bone Dis, Xiangya Hosp 2, Changsha, Peoples R China.; Yuan, LQ (corresponding author), Cent South Univ, Xiangya Hosp 2, Dept Endocrinol & Metab, Changsha, Peoples R China.
EM allenylq@csu.edu.cn
RI Shan, Su-kang/JFS-7113-2023; Xu, Feng/AAE-6486-2020; Yuan,
   Ling-Qing/HZL-9093-2023; Wang, Yi/IZE-7930-2023; Ullah,
   Ehsan/IYJ-5471-2023; Yuan, Ling-Qing/D-2102-2019
OI Yuan, Ling-Qing/0000-0001-8602-7113; lin, xiao/0000-0002-6039-3630; Xu,
   Feng/0000-0003-0902-2858
FU National Natural Science Foundation of China [81770881, 82070910]
FX This work was supported by funding from the National Natural Science
   Foundation of China (Nos. 81770881 and 82070910).
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NR 112
TC 27
Z9 28
U1 0
U2 8
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-042X
J9 FRONT PHYSIOL
JI Front. Physiol.
PD DEC 3
PY 2020
VL 11
AR 570270
DI 10.3389/fphys.2020.570270
PG 11
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA PF8TO
UT WOS:000599320100001
PM 33343381
OA Green Published, gold
DA 2025-06-11
ER

PT S
AU Akyuz, A
AF Akyuz, Aydin
BE Xiao, J
TI Exercise and Coronary Heart Disease
SO PHYSICAL EXERCISE FOR HUMAN HEALTH
SE Advances in Experimental Medicine and Biology
LA English
DT Article; Book Chapter
DE Coronary heart disease; Dynamic exercise; Static exercise
ID CARDIOVASCULAR-ABNORMALITIES PREAMBLE; ELEVATION MYOCARDIAL-INFARCTION;
   PRACTICE GUIDELINES COMMITTEE; HEALTH-CARE PROFESSIONALS; ASSOCIATION
   TASK-FORCE; QUALITY-OF-LIFE; CARDIAC REHABILITATION; ARTERY-DISEASE;
   PHYSICAL-ACTIVITY; AMERICAN-COLLEGE
AB Coronary artery disease (CAD) can be obstructive or nonobstructive. Patients with nonobstructive and stable angina pectoris are usually women. Nonobstructive CAD is caused by endothelial dysfunction at the microvascular level, such as cardiac syndrome X and coronary slow flow syndrome. Even if coronary anatomy is nonobstructive, the presence of myocardial ischemia is a major determinant for the exercise program. CAD is a chronic inflammatory disease, and the progression of the disease can lead to a rapid change in the functional capacity of CAD patients. Exercise training is a major component of cardiac rehabilitation and reduces cardiovascular mortality, morbidity, and rehospitalization as well as improves psychological stress and controls risk factors of CAD, such as diabetes mellitus, hypertension, and obesity. It is possible that the quality of life of patients with CAD can be improved by using appropriate exercise therapy. However, the exercise programs among CAD patients are highly underutilized. This chapter will summarize the research progress of exercise in the prevention and treatment of CAD as well as how to create safe exercise programs and the importance of exercise for patients with CAD. In addition, exercise training has fundamental beneficial effects on ischemic and nonischemic heart failure.
C1 [Akyuz, Aydin] Namik Kemal Univ, Univ Hosp, Dept Cardiol, Fac Med, Tekirdag, Turkey.
C3 Namik Kemal University
RP Akyuz, A (corresponding author), Namik Kemal Univ, Univ Hosp, Dept Cardiol, Fac Med, Tekirdag, Turkey.
EM aakyuz@nku.edu.tr
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NR 81
TC 34
Z9 34
U1 8
U2 72
PU SPRINGER-VERLAG SINGAPORE PTE LTD
PI SINGAPORE
PA 152 BEACH ROAD, #21-01/04 GATEWAY EAST, SINGAPORE, 189721, SINGAPORE
SN 0065-2598
EI 2214-8019
BN 978-981-15-1792-1; 978-981-15-1791-4
J9 ADV EXP MED BIOL
JI Adv.Exp.Med.Biol.
PY 2020
VL 1228
BP 169
EP 179
DI 10.1007/978-981-15-1792-1_11
D2 10.1007/978-981-15-1792-1
PG 11
WC Medicine, Research & Experimental; Physiology; Sport Sciences
WE Book Citation Index – Science (BKCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Physiology; Sport Sciences
GA BQ5AS
UT WOS:000596720900011
PM 32342457
DA 2025-06-11
ER

PT J
AU do Moinho, TM
   Matos, SL
   Carvalho, CRO
AF do Moinho, Tais Menezes
   Matos, Sandro Leao
   Carvalho, Carla R. O.
TI A comprehensive review on phytochemicals for fatty liver: are they
   potential adjuvants?
SO JOURNAL OF MOLECULAR MEDICINE-JMM
LA English
DT Review
DE Fatty liver; NAFLD; Phytochemicals; Traditional medicine; Metabolic
   syndrome
ID ACTIVATED PROTEIN-KINASE; GINKGO-BILOBA EXTRACT; KOREAN RED GINSENG;
   FACTOR-KAPPA-B; INSULIN-RESISTANCE; HEPATIC STEATOSIS;
   UNCARIA-TOMENTOSA; OXIDATIVE STRESS; IN-VITRO; LIPID-METABOLISM
AB Non-alcoholic fatty liver disease (NAFLD) is considered the hepatic manifestation of metabolic syndrome and, as such, is associated with obesity. With the current and growing epidemic of obesity, NAFLD is already considered the most common liver disease in the world. Currently, there is no official treatment for the disease besides weight loss. Although there are a few synthetic drugs currently being studied, there is also an abundance of herbal products that could also be used for treatment. With the World Health Organization (WHO) traditional medicine strategy (2014-2023) in mind, this review aims to analyze the mechanisms of action of some of these herbal products, as well as evaluate toxicity and herb-drug interactions available in literature.
C1 [do Moinho, Tais Menezes; Matos, Sandro Leao; Carvalho, Carla R. O.] Univ Sao Paulo, Inst Biomed Sci, Dept Physiol & Biophys, BR-05508000 Sao Paulo, Brazil.
C3 Universidade de Sao Paulo; Institute Biomed Science, University Sao
   Paulo
RP Carvalho, CRO (corresponding author), Univ Sao Paulo, Inst Biomed Sci, Dept Physiol & Biophys, BR-05508000 Sao Paulo, Brazil.
EM croc@icb.usp.br
RI Menezes do Moinho, Taís/CAI-0341-2022; Carvalho, Carla/H-6476-2018
OI Carvalho, Carla/0000-0001-5824-8656; Moinho, Tais/0000-0001-5996-8647;
   Leao, Sandro/0000-0002-4701-6769
FU Brazilian research agency: Fundacao de Amparo a Pesquisa do Estado de
   Sao Paulo [FAPESP - 2019/20464-8]; Brazilian research agency: Conselho
   Nacional de Desenvolvimento Cientifico e Tecnologico [CNPq -
   308093/2019-4, CNPq - 141743/2019-0]
FX This study was supported by grants from the Brazilian research agencies:
   Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP -
   2019/20464-8), and Conselho Nacional de Desenvolvimento Cientifico e
   Tecnologico (CNPq - 308093/2019-4, and CNPq - 141743/2019-0).
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NR 160
TC 6
Z9 6
U1 2
U2 17
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0946-2716
EI 1432-1440
J9 J MOL MED
JI J. Mol. Med.
PD MAR
PY 2022
VL 100
IS 3
BP 411
EP 425
DI 10.1007/s00109-021-02170-3
EA JAN 2022
PG 15
WC Genetics & Heredity; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Genetics & Heredity; Research & Experimental Medicine
GA YY9ZA
UT WOS:000739786500001
PM 34993581
DA 2025-06-11
ER

PT J
AU Guest, PC
   Chan, MK
   Gottschalk, MG
   Bahn, S
AF Guest, Paul C.
   Chan, Man K.
   Gottschalk, Michael G.
   Bahn, Sabine
TI The use of proteomic biomarkers for improved diagnosis and
   stratification of schizophrenia patients
SO BIOMARKERS IN MEDICINE
LA English
DT Review
DE brain; comorbidities; inflammation; metabolic syndrome; personalized
   medicine; proteomics; schizophrenia; serum
ID PITUITARY-ADRENAL AXIS; PLACEBO-CONTROLLED TRIAL; DRUG-NAIVE PATIENTS;
   OXIDATIVE STRESS MARKERS; INSULIN-RESISTANCE; DOUBLE-BLIND;
   PSYCHIATRIC-DISORDERS; ALZHEIMERS-DISEASE; METABOLIC SYNDROME;
   SUPEROXIDE-DISMUTASE
AB Schizophrenia is characterized by a wide spectrum of clinical manifestations, including strong effects on mood and behavior. Patients can also suffer from serious comorbidities including immune system or metabolic abnormalities. Recent advances using proteomic profiling approaches have increased our understanding of these molecular effects and have laid the groundwork for unraveling the heterogeneity of this broadly defined disease. These findings could lead to improved diagnosis and stratification of patients through identification of biochemically different disease subtypes and personalized medicine approaches. The inclusion of molecular signatures in psychiatry will be an important leap forward in providing more effective treatment of patients suffering from this debilitating disorder.
C1 [Guest, Paul C.; Chan, Man K.; Gottschalk, Michael G.; Bahn, Sabine] Univ Cambridge, Dept Chem Engn & Biotechnol, Cambridge, England.
   [Bahn, Sabine] Erasmus MC, Dept Neurosci, Rotterdam, Netherlands.
C3 University of Cambridge; Erasmus University Rotterdam; Erasmus MC
RP Bahn, S (corresponding author), Univ Cambridge, Dept Chem Engn & Biotechnol, Cambridge, England.
EM sb209@cam.ac.uk
RI Gottschalk, Michael/AAZ-8925-2020
OI Chan, Man/0000-0002-4866-5170; guest, paul/0000-0002-5030-7137;
   Gottschalk, Michael/0000-0002-2386-3701
FU Stanley Medical Research Institute; Dutch Fund for Economic Structure
   Reinforcement (FES) [0908]; European Union [223427]
FX This work was supported by grants from the Stanley Medical Research
   Institute, the Dutch Fund for Economic Structure Reinforcement (FES)
   under grant agreement number 0908 (NeuroBasic PharmaPhenomics project),
   and the European Union FP7 SchizDX research programme (grant reference
   223427). PC Guest and S Bahn are consultants for Myriad-RBM, although
   this does not interfere with ownership regarding data sharing or
   materials. The authors have no other relevant affiliations or financial
   involvement with any organization or entity with a financial interest in
   or financial conflict with the subject matter or materials discussed in
   the manuscript apart from those disclosed.
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NR 114
TC 29
Z9 30
U1 0
U2 22
PU FUTURE MEDICINE LTD
PI LONDON
PA UNITEC HOUSE, 3RD FLOOR, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON, N3
   1QB, ENGLAND
SN 1752-0363
EI 1752-0371
J9 BIOMARK MED
JI Biomark. Med.
PD JAN
PY 2014
VL 8
IS 1
BP 15
EP 27
DI 10.2217/bmm.13.83
PG 13
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA AI9BF
UT WOS:000337220700005
PM 24325222
DA 2025-06-11
ER

PT J
AU Jin, Y
   Heo, KS
AF Jin, Yujin
   Heo, Kyung-Sun
TI Experimental model and novel therapeutic targets for non-alcoholic fatty
   liver disease development
SO KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY
LA English
DT Review
DE Drug targeting; Hepatitis; Metabolic syndrome; Non-alcoholic fatty liver
   disease
ID LIPID-ACCUMULATION; MOUSE MODEL; ER STRESS; INFLAMMATION; APOPTOSIS;
   ACTIVATION; FIBROSIS; PATHWAY; CANCER; STEATOHEPATITIS
AB Non-alcoholic fatty liver disease (NAFLD) is a complex disorder characterized by the accumulation of fat in the liver in the absence of excessive alcohol consumption. It is one of the most common liver diseases worldwide, affecting approximately 25% of the global population. It is closely associated with obesity, type 2 diabetes, and metabolic syndrome. Moreover, NAFLD can progress to non-alcoholic steatohepatitis, which can cause liver cirrhosis, liver failure, and hepatocellular carcinoma. Currently, there are no approved drugs for the treatment of NAFLD. Therefore, the development of effective drugs is essential for NAFLD treatment. In this article, we discuss the experimental models and novel therapeutic targets for NAFLD. Additionally, we propose new strategies for the development of drugs for NAFLD.
C1 [Heo, Kyung-Sun] Chungnam Natl Univ, Coll Pharm, Daejeon 34134, South Korea.
   Chungnam Natl Univ, Inst Drug Res & Dev, Daejeon 34134, South Korea.
C3 Chungnam National University; Chungnam National University
RP Heo, KS (corresponding author), Chungnam Natl Univ, Coll Pharm, Daejeon 34134, South Korea.
EM kheo@cnu.ac.kr
RI Jin, Yujin/MEP-9121-2025; HEO, KYUNGSUN/LPQ-6041-2024
FU National Research Foundation of Korea (NRF) - Ministry of Science, ICT
   and Future Planning [2019R1C1C100733112]
FX This research was supported by the National Research Foundation of Korea
   (NRF) funded by the Ministry of Science, ICT and Future Planning
   (2019R1C1C100733112).
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NR 104
TC 5
Z9 5
U1 5
U2 14
PU KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY
PI SEOUL
PA C/O EDITORIAL OFFICE, 448-13 SEOKYO-DONG, SEOUL, SOUTH KOREA
SN 1226-4512
EI 2093-3827
J9 KOREAN J PHYSIOL PHA
JI KOREAN J. PHYSIOL. PHARMACOL.
PD JUL
PY 2023
VL 27
IS 4
BP 299
EP 310
DI 10.4196/kjpp.2023.27.4.299
PG 12
WC Pharmacology & Pharmacy; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Physiology
GA L8OL7
UT WOS:001025801700002
PM 37386828
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU LaChance, L
   Aucoin, M
   Cooley, K
AF LaChance, Laura
   Aucoin, Monique
   Cooley, Kieran
TI Design and pilot evaluation of an evidence-based worksheet and clinician
   guide to facilitate nutrition counselling for patients with severe
   mental illness
SO BMC PSYCHIATRY
LA English
DT Article
DE Diet; Nutrition; Worksheet; Psychosis; Schizophrenia; Counseling;
   Lifestyle; Knowledge translation; Clinical tool; Patient education
ID SCHIZOPHRENIA SPECTRUM DISORDERS; CARDIOMETABOLIC RISK; CARE;
   INDIVIDUALS; INFORMATION; PSYCHOSIS; PEOPLE
AB Background Schizophrenia spectrum disorders (SSD) are severe, persistent mental illnesses resulting in considerable disability and premature mortality. Emerging evidence suggests that diet may be a modifiable risk factor in mental illness; however, use of nutritional counselling as a component of psychiatric clinical practice is limited. The objective of this project is the design and evaluate a worksheet and clinician guide for use in facilitating nutritional counseling in the context of existing mental health care. Methods The worksheet and clinician guide were developed based on the results of a recent scoping review on the relationship between diet and mental health symptoms among individuals with SSD. A feedback process involved a focus group with psychiatrists and interviews with individuals with lived experience with psychosis. Participants were asked a series of structured and open-ended questions. Interviews were transcribed and data units were allocated to categories from an existing framework. The comments were used to guide modifications to the worksheet and clinician guide. A brief interview with all participants was completed to gather feedback on the final version. Results Five psychiatrist participants and six participants with lived experience completed interviews. Participants provided positive comments related to the worksheet design, complexity and inclusion of interactive components. A novel theme emerged relating to the lack of nutritional counselling in psychiatric training and clinical practice. Many constructive comments were provided which resulted in meaningful revisions and improvements to the worksheet and clinician guide design and content. All participants were satisfied with the final versions. Conclusions A worksheet and clinician guide designed to facilitate nutritional counselling with individuals with SSD was found to be acceptable to all participants following a process of feedback and revision. Further research and dissemination efforts aimed at increasing the use of nutritional counselling in psychiatric practice are warranted.
C1 [LaChance, Laura] McGill Univ, Dept Psychiat, Ludmer Res & Training Bldg,1033 Pine Ave West, Montreal, PQ H3A 1A1, Canada.
   [LaChance, Laura] St Marys Hosp, 3830 Lacombe Ave, Montreal, PQ H3T 1M5, Canada.
   [Aucoin, Monique; Cooley, Kieran] Canadian Coll Naturopath Med, 1255 Sheppard Ave E, N York, ON M2K 1E2, Canada.
   [Cooley, Kieran] Univ Technol Sydney, Ultimo, Australia.
   [Cooley, Kieran] Pacific Coll Hlth Sci, San Diego, CA USA.
   [Cooley, Kieran] Southern Cross Univ, Natl Ctr Naturopath Med, Lismore, NSW, Australia.
C3 McGill University; University of Technology Sydney; Southern Cross
   University
RP LaChance, L (corresponding author), McGill Univ, Dept Psychiat, Ludmer Res & Training Bldg,1033 Pine Ave West, Montreal, PQ H3A 1A1, Canada.; LaChance, L (corresponding author), St Marys Hosp, 3830 Lacombe Ave, Montreal, PQ H3T 1M5, Canada.
EM laura.lachance@mail.mcgill.ca
RI Cooley, Kieran/L-3080-2019; Aucoin, Monique/KHX-8889-2024
FU Canadian CAM Research Fund
FX This project was funded by the Canadian CAM Research Fund. The funders
   did not play a role in the study design, conduct, data analysis,
   interpretation, or manuscript preparation.
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NR 43
TC 0
Z9 0
U1 0
U2 1
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-244X
J9 BMC PSYCHIATRY
JI BMC Psychiatry
PD NOV 10
PY 2021
VL 21
IS 1
AR 556
DI 10.1186/s12888-021-03575-7
PG 11
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA WV0NN
UT WOS:000716933500005
PM 34758760
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Vinberg, M
   Mcintyre, RS
   Giraldi, A
   Coello, K
AF Vinberg, Maj
   Mcintyre, Roger S.
   Giraldi, Annamaria
   Coello, Klara
TI Struggling Can Also Show on the Inside: Current Knowledge of the Impact
   of Childhood Maltreatment on Biomarkers in Mood Disorderss
SO NEUROPSYCHIATRIC DISEASE AND TREATMENT
LA English
DT Review
DE biomarkers; childhood maltreatment; mood disorders; biosignatures;
   biotype
ID PITUITARY-ADRENAL AXIS; BIPOLAR DISORDER; SALIVARY CORTISOL;
   NEUROTROPHIC FACTOR; METABOLIC SYNDROME; HEALTHY TWINS; LOW-RISK;
   EXPERIENCES; DEPRESSION; STRESS
AB The link between childhood maltreatment and mood disorders is complex and involves multiple bio-psycho-social factors that affect multiple molecular pathways. The present narrative review aims to clarify the current understanding of the impact of childhood maltreatment on biomarkers in patients with mood disorders and their first-degree relatives. Neurotransmitters, such as serotonin, dopamine, norepinephrine, and hormones (eg the stress hormone cortisol), play a crucial role in regulating mood and emotion. Childhood maltreatment can alter and affect the levels and functioning of these neurotransmitters in the brain; further, childhood maltreatment can lead to structural and connectivity changes in the brain, hence contributing to the development of mood disorders and moderating illness presentation and modifying response to treatments. Childhood maltreatment information, therefore, appears mandatory in treatment planning and is a critical factor in therapeutic algorithms. Further research is needed to fully understand these pathways and develop new treatment modalities for individuals with mood disorders who have experienced childhood maltreatment and effective preventive interventions for individuals at risk of developing mood disorders.
C1 [Vinberg, Maj] Mental Hlth Ctr Northern Zealand, Early Multimodular Prevent & Intervent Res Inst EM, Mental Hlth Serv CPH, Copenhagen, Denmark.
   [Vinberg, Maj; Giraldi, Annamaria] Univ Copenhagen, Dept Clin Med, Copenhagen, Denmark.
   [Mcintyre, Roger S.] Univ Hlth Network, Toronto Western Hosp, Mood Disorders Psychopharmacol Unit, Toronto, ON, Canada.
   [Mcintyre, Roger S.] Univ Toronto, Inst Med Sci, Toronto, ON, Canada.
   [Giraldi, Annamaria] Copenhagen Univ Hosp, Mental Hlth Ctr Copenhagen, Sexol Clin, Copenhagen, Denmark.
   [Coello, Klara] Copenhagen Affect Disorder Res Ctr CAD, Psychiat Ctr Copenhagen, Frederiksberg, Denmark.
   [Vinberg, Maj] Dyrehavevej 48, DK-3400 Hillerod, Denmark.
C3 University of Copenhagen; University of Toronto; University Health
   Network Toronto; University of Toronto; University of Copenhagen;
   Copenhagen University Hospital
RP Vinberg, M (corresponding author), Dyrehavevej 48, DK-3400 Hillerod, Denmark.
EM maj.vinberg@regionh.dk
RI Coello, Klara/AAZ-6545-2020; Vinberg/ABC-7493-2021; Giraldi,
   Annamaria/AAW-6292-2020; McIntyre, Roger/C-9998-2019
OI Vinberg, Maj/0000-0002-5982-1335
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NR 115
TC 1
Z9 1
U1 1
U2 3
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
EI 1178-2021
J9 NEUROPSYCH DIS TREAT
JI Neuropsychiatr. Dis. Treat.
PY 2024
VL 20
BP 583
EP 595
DI 10.2147/NDT.S383322
PG 13
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Psychiatry
GA LD4U3
UT WOS:001184836400001
PM 38496323
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Jee, SH
   Kim, HJ
   Lee, J
AF Jee, SH
   Kim, HJ
   Lee, J
TI Obesity, insulin resistance and cancer risk
SO YONSEI MEDICAL JOURNAL
LA English
DT Review
DE obesity; insulin resistance; cancer; mechanism
ID DIABETES-MELLITUS; BREAST-CANCER; COLORECTAL-CANCER; METABOLIC SYNDROME;
   OXIDATIVE STRESS; KOREAN MEN; CARDIOVASCULAR-DISEASE; GLUCOSE;
   HYPERTENSION; COLON
AB Obesity is a known cause of metabolic syndrome which includes Type 11 diabetes, hypertension, and dyslipidemia. it is well documented that insulin resistance contributes to the mortality and the incidence of metabolic syndromes including central obesity, dyslipidemia, hyperglycemia and hypertension. Both obesity and diabetes are emerging topics for researchers to consider as having a possible causal association with cancer since the two factors have been viewed as risk factors for cancer. The present paper introduced the hypothesis of a possible causal relationship between obesity, insulin resistance and cancer and reviews relevant existing studies in this area. More efforts and studies are needed to clarify the mechanisms and the common risk factors which might be incorporated into interventions to prevent cancer and cardiovascular diseases as top causes of death.
C1 Yonsei Univ, Grad Sch Publ Hlth, Dept Epidemiol & Hlth Promot, Seoul 120752, South Korea.
   Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA.
   Eulji Univ, Sch Med, Dept Family Med, Seoul, South Korea.
C3 Yonsei University; Yonsei University Health System; Johns Hopkins
   University; Johns Hopkins Bloomberg School of Public Health; Eulji
   University
RP Yonsei Univ, Grad Sch Publ Hlth, Dept Epidemiol & Hlth Promot, 134 Shinchon Dong, Seoul 120752, South Korea.
EM jsunha@yumc.yonsei.ac.kr
RI Jiang, Shu-Heng/M-6584-2019
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NR 36
TC 69
Z9 78
U1 0
U2 6
PU YONSEI UNIV COLL MEDICINE
PI SEOUL
PA 50-1 YONSEI-RO, SEODAEMUN-GU, SEOUL 120-752, SOUTH KOREA
SN 0513-5796
EI 1976-2437
J9 YONSEI MED J
JI Yonsei Med. J.
PD AUG 31
PY 2005
VL 46
IS 4
BP 449
EP 455
DI 10.3349/ymj.2005.46.4.449
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 961CR
UT WOS:000231640000001
PM 16127767
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Bhutia, RD
   Khandelwal, B
   Sherpa, ML
   Singh, TA
AF Bhutia, Rinchen D.
   Khandelwal, Bidita
   Sherpa, Mingma L.
   Singh, T. A.
TI Oxidation products of DNA, lipid and protein among the individuals
   progressing towards metabolic syndrome
SO INDIAN JOURNAL OF BIOCHEMISTRY & BIOPHYSICS
LA English
DT Article
DE DNA damage; Lipid peroxidation; Metabolic syndrome; Oxidative stress;
   Protein carbonyl
ID INHIBITOR KAPPA-B; MONONUCLEAR-CELLS; URINARY
   8-HYDROXY-2'-DEOXYGUANOSINE; INCREASE; STRESS; DECREASE; OXYGEN;
   DISEASE; MARKERS; DAMAGE
AB Oxidative stress (OS) is an early event and at the same time also a consequence in the pathology of MetS. We investigated if oxidation markers of DNA, lipid and protein increased with an increase in the risk parameters of MetS. Participants (male:70, female:90 >= 20 yrs) were categorized based on the number of risk factors they had as 3 Risk, 2 Risk, 1 Risk and 0 Risk for MetS and were evaluated for various oxidation markers. Protein carbonyl and advanced oxidation protein product (protein oxidation marker) differed significantly between the four study group while malondialdehyde and hydroxynonenal (lipid peroxidation marker) did not. "8-OH dG" (DNA oxidation marker) differed significantly (P< 0.05) while total antioxidant capacity did not demonstrate significant difference in its values across the group (P> 0.05). Pairwise comparison for statistically significant markers(Protein oxidation markers and 8-OH dG), demonstrated that only 8-OH dG differed significantly between 0 Risk-3 Risk (P< 0.012) but not between 0 Risk-2 Risk and 0 Risk-1 Risk. Oxidative stress markers of DNA, lipid and protein do not increase with an increase in the risk parameters of MetS. However, it is indeed high in MetS with 3 and more risk parameters. Presence of 2 or 1 Risk also increases OS compared to 0 Risk. There is oxidative stress damage in MetS to lipid and protein but DNA damage was of significant consequence.
C1 [Bhutia, Rinchen D.; Khandelwal, Bidita; Sherpa, Mingma L.; Singh, T. A.] Sikkim Manipal Univ, Med Sikkim Manipal Inst Med Sci, Dept Biochem, Gangtok 737102, East Sikkim, India.
C3 Sikkim Manipal University
RP Bhutia, RD (corresponding author), Sikkim Manipal Univ, Med Sikkim Manipal Inst Med Sci, Dept Biochem, Gangtok 737102, East Sikkim, India.
EM nehcnir@yahoo.co.in
RI Sherpa, Mingma/ABB-7061-2021; Bhutia, Rinchen/AAE-6172-2021; khandelwal,
   bidita/K-4935-2012
OI Bhutia, Rinchen Doma/0000-0001-8463-2854; Sherpa, Mingma
   L/0000-0002-5905-6127
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PU NATL INST SCIENCE COMMUNICATION-NISCAIR
PI NEW DELHI
PA DR K S KRISHNAN MARG, PUSA CAMPUS, NEW DELHI 110 012, INDIA
SN 0301-1208
EI 0975-0959
J9 INDIAN J BIOCHEM BIO
JI Indian J. Biochem. Biophys.
PD APR
PY 2019
VL 56
IS 2
BP 155
EP 161
PG 7
WC Biochemistry & Molecular Biology; Biophysics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics
GA HW6QW
UT WOS:000466816200008
DA 2025-06-11
ER

PT J
AU Musso, G
   Paschetta, E
   Gambino, R
   Cassader, M
   Molinaro, F
AF Musso, Giovanni
   Paschetta, Elena
   Gambino, Roberto
   Cassader, Maurizio
   Molinaro, Federica
TI Interactions among bone, liver, and adipose tissue predisposing to
   diabesity and fatty liver
SO TRENDS IN MOLECULAR MEDICINE
LA English
DT Review
ID SERUM OSTEOCALCIN LEVELS; ENDOPLASMIC-RETICULUM STRESS;
   NECROSIS-FACTOR-ALPHA; FETUIN-A; INSULIN-RESISTANCE; MINERAL DENSITY;
   RECEPTOR ACTIVATOR; NONALCOHOLIC STEATOHEPATITIS;
   HEPATOCELLULAR-CARCINOMA; METABOLIC SYNDROME
AB Growing epidemiological evidence connects obesity and its complications, including metabolic syndrome, diabetes, and nonalcoholic fatty liver disease (NAFLD) to reduced bone health and osteoporosis. Parallel to human studies, experimental data disclosed a complex network of interaction among adipose tissue, the liver, and the bone, which reciprocally modulate the function of each other. The main mediators of such crosstalk include hormonal/cytokine signals from the bone (osteopontin, osteocalcin, and osteoprotegerin), the liver (fetuin-A), and adipose tissue [leptin, tumor necrosis factor-alpha (TNF-alpha), and adiponectin]. Dysregulation of this network promotes the development of diabesity, NAFLD, and osteoporosis. We will review recent advances in understanding the mechanisms of bone-liver-adipose tissue interaction predisposing to obesity, diabetes, NAFLD, and osteoporosis and their potential clinical implications.
C1 [Musso, Giovanni] Univ Turin, Gradenigo Hosp, Turin, Italy.
   [Paschetta, Elena; Gambino, Roberto; Cassader, Maurizio; Molinaro, Federica] Univ Turin, San Giovanni Battista Hosp, Dept Med Sci, Turin, Italy.
C3 University of Turin; Humanitas Hospital Gradenigo; University of Turin;
   A.O.U. Citta della Salute e della Scienza di Torino; AOU San Giovanni
   Battista-Molinette
RP Musso, G (corresponding author), Univ Turin, Gradenigo Hosp, Turin, Italy.
EM giovanni_musso@yahoo.it
RI Musso, Giovanni/AAB-7884-2022; GAMBINO, Roberto/AAC-7517-2022
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   Zhao J, 2008, GASTROENTEROLOGY, V135, P956, DOI 10.1053/j.gastro.2008.05.025
   Zhou B, 2013, ENDOCRINOLOGY, V154, P1055, DOI 10.1210/en.2012-2144
   Zou W, 2001, J CELL BIOCHEM, V83, P70, DOI 10.1002/jcb.1202
NR 141
TC 73
Z9 87
U1 0
U2 34
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1471-4914
EI 1471-499X
J9 TRENDS MOL MED
JI Trends Mol. Med
PD SEP
PY 2013
VL 19
IS 9
BP 522
EP 535
DI 10.1016/j.molmed.2013.05.006
PG 14
WC Biochemistry & Molecular Biology; Cell Biology; Medicine, Research &
   Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology; Research & Experimental
   Medicine
GA 226TJ
UT WOS:000325058600003
PM 23816817
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Bánhegyi, G
   Csala, M
   Benedetti, A
AF Banhegyi, Gabor
   Csala, Miklos
   Benedetti, Angelo
TI Hexose-6-phosphate dehydrogenase: linking endocrinology and metabolism
   in the endoplasmic reticulum
SO JOURNAL OF MOLECULAR ENDOCRINOLOGY
LA English
DT Review
ID PITUITARY-ADRENAL AXIS; FATTY-ACID CYCLE; 11-BETA-HYDROXYSTEROID
   DEHYDROGENASE; ADIPOSE-TISSUE; PYRIDINE-NUCLEOTIDES; NADPH/NADP(+)
   RATIO; PANCREATIC-ISLETS; TYPE-1 ACTIVITY; ER STRESS; GLUCOSE
AB Hexose-6-phosphate dehydrogenase (H6PD) got into the focus of interest due to its role in the prereceptorial activation of glucocorticoids, which has been implicated in the pathomechanism of metabolic syndrome. Genetic observations, results gained in H6PD knockout mice, and studies on differentiating adipocytes demonstrated the importance of the enzyme in metabolic regulation. A nutrient-sensing function can be postulated for the enzyme, which links metabolism to endocrinology in the endoplasmic reticulum. This review provides an overview of the recent developments concerning the enzyme and its impact on various branches of the intermediary metabolism, which make it an important subject for the research on obesity, diabetes, and metabolic syndrome. Journal of Molecular Endocrinology (2009) 42, 283-289
C1 [Banhegyi, Gabor; Benedetti, Angelo] Univ Siena, Dipartimento Fisiopatol Med Sperimentale & Sanita, I-53100 Siena, Italy.
   [Banhegyi, Gabor; Csala, Miklos] Semmelweis Univ, Dept Med Chem Mol Biol & Pathobiochem, H-1444 Budapest, Hungary.
   [Banhegyi, Gabor; Csala, Miklos] MTA SE Pathobiochem Res Grp, H-1444 Budapest, Hungary.
C3 University of Siena; Semmelweis University; Semmelweis University
RP Benedetti, A (corresponding author), Univ Siena, Dipartimento Fisiopatol Med Sperimentale & Sanita, Via Aldo Moro, I-53100 Siena, Italy.
EM benedetti@unisi.it
RI Csala, Miklos/H-5369-2011; Bánhegyi, Gábor/A-1476-2014
OI Csala, Miklos/0000-0002-3829-4361
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NR 66
TC 32
Z9 39
U1 0
U2 5
PU BIOSCIENTIFICA LTD
PI BRISTOL
PA EURO HOUSE, 22 APEX COURT WOODLANDS, BRADLEY STOKE, BRISTOL BS32 4JT,
   ENGLAND
SN 0952-5041
EI 1479-6813
J9 J MOL ENDOCRINOL
JI J. Mol. Endocrinol.
PD MAR-APR
PY 2009
VL 42
IS 3-4
BP 283
EP 289
DI 10.1677/JME-08-0156
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 530ZA
UT WOS:000272630300010
PM 19060178
DA 2025-06-11
ER

PT J
AU Kondo, S
   Kamei, A
   Xiao, JZ
   Iwatsuki, K
   Abe, K
AF Kondo, S.
   Kamei, A.
   Xiao, J. Z.
   Iwatsuki, K.
   Abe, K.
TI Bifidobacterium breve B-3 exerts metabolic syndrome-suppressing
   effects in the liver of diet-induced obese mice: a DNA microarray
   analysis
SO BENEFICIAL MICROBES
LA English
DT Article
DE Bifidobacterium breve; anti-obesity; gene expressions
ID GUT MICROBIOTA; INDUCED INFLAMMATION; LINOLEIC-ACID; FATTY-ACIDS;
   ANTIOBESITY; EXPRESSION
AB We previously reported that supplementation with Bifidobacterium breve B-3 reduced body weight gain and accumulation of visceral fat in a dose-dependent manner, and improved serum levels of total cholesterol, glucose and insulin in a mouse model of diet-induced obesity. In this study, we investigated the expression of genes in the liver using DNA microarray analysis and q-PCR to reveal the mechanism of these anti-obesity effects in this mouse model. Administration of B. breve B-3 led to regulated gene expression of pathways involved in lipid metabolism and response to stress. The results indicate that these regulations in the liver are related to the anti-metabolic syndrome effects of B. breve B-3.
C1 [Abe, K.] Univ Tokyo, Grad Sch Agr & Life Sci, Dept Appl Biol Chem, Bunkyo Ku, Tokyo 1138657, Japan.
C3 University of Tokyo
EM j_xiao@morinagamilk.co.jp
RI Xiao, Jinzhong/HIR-9791-2022; Kamei, Asuka/GXH-4934-2022
FU Grants-in-Aid for Scientific Research [23248058, 25560046] Funding
   Source: KAKEN
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NR 22
TC 28
Z9 29
U1 0
U2 19
PU WAGENINGEN ACADEMIC PUBLISHERS
PI WAGENINGEN
PA PO BOX 220, WAGENINGEN, 6700 AE, NETHERLANDS
SN 1876-2883
EI 1876-2891
J9 BENEF MICROBES
JI Benef. Mirbobes
PD SEP
PY 2013
VL 4
IS 3
BP 247
EP 251
DI 10.3920/BM2012.0019
PG 5
WC Microbiology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Microbiology; Nutrition & Dietetics
GA 200ER
UT WOS:000323051100005
PM 23666099
DA 2025-06-11
ER

PT J
AU Basu, A
   Devaraj, S
   Jialal, I
AF Basu, A
   Devaraj, S
   Jialal, I
TI Dietary factors that promote or retard inflammation
SO ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
LA English
DT Review
DE C-reactive protein; diet; inflammation; macronutrients; micronutrients;
   weight loss
ID C-REACTIVE PROTEIN; ALPHA-LINOLENIC ACID; N-3 FATTY-ACIDS; RISK-FACTORS;
   FISH-OIL; ENDOTHELIAL DYSFUNCTION; CARDIOVASCULAR-DISEASE; METABOLIC
   SYNDROME; PLASMA BIOMARKERS; OXIDATIVE STRESS
AB Inflammation plays a pivotal role in all stages of atherosclerosis. Cardiovascular risk factors and metabolic syndrome are typified by low-grade inflammation. Intervention trials convincingly demonstrate that weight loss reduces biomarkers of inflammation, such as C-reactive protein (CRP) and interleukin (IL)-6. Limited studies have shown that certain dietary factors; oleic acid, alpha-linolenic acid, and antioxidants RRR-alpha-alpha tocopherol, reduce biomarkers of inflammation. Most of the studies with fish oil supplementation have shown null effects, and conflicting results have been reported with saturated and trans fatty acids, cholesterol, and soy intake. Much further research is needed to define the role of individual dietary factors on the biomarkers of inflammation and the mechanism of the anti-inflammatory effects of weight loss.
C1 Univ Calif Davis, Med Ctr, Lab Atherosclerosis & Metab Res, Sacramento, CA 95817 USA.
C3 University of California System; University of California Davis
RP Univ Calif Davis, Med Ctr, Lab Atherosclerosis & Metab Res, 4635 2nd Ave,Res Bldg 1,Room 3000, Sacramento, CA 95817 USA.
EM ishwarlal.jialal@ucdmc.ucdavis.edu
RI Jialal, Ishwarlal/AAG-6218-2019
FU NCCIH NIH HHS [K24AT00596] Funding Source: Medline; NHLBI NIH HHS
   [HL074360] Funding Source: Medline
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   2005, ANN INTERN MED, V143, P150
NR 58
TC 164
Z9 256
U1 0
U2 15
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1079-5642
EI 1524-4636
J9 ARTERIOSCL THROM VAS
JI Arterioscler. Thromb. Vasc. Biol.
PD MAY
PY 2006
VL 26
IS 5
BP 995
EP 1001
DI 10.1161/01.ATV.0000214295.86079.d1
PG 7
WC Hematology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Hematology; Cardiovascular System & Cardiology
GA 034PF
UT WOS:000236942400008
PM 16484595
OA Bronze, Green Submitted
DA 2025-06-11
ER

PT J
AU Calvi, P
   Terzo, S
   Amato, A
AF Calvi, Pasquale
   Terzo, Simona
   Amato, Antonella
TI Betalains: colours for human health
SO NATURAL PRODUCT RESEARCH
LA English
DT Article
DE Betalains; metabolic syndrome; obesity; Opuntia ficus indica
ID ATTENUATES OXIDATIVE STRESS; FATTY LIVER-DISEASE; BETA-VULGARIS L.;
   CACTUS PEAR; ANTIOXIDANT ACTIVITY; BEETROOT JUICE; BLOOD-PRESSURE;
   INCREASED RESISTANCE; INSULIN-RESISTANCE; OLDER OVERWEIGHT
AB In the last years, the use of natural phytochemical compounds as protective agents in the prevention and treatment of obesity and the related-metabolic syndrome has gained much attention worldwide. Different studies have shown health benefits for many vegetables such Opuntia ficus-indica and Beta vulgaris and their pigments collectively referred as betalains. Betalains exert antioxidative, anti-inflammation, lipid lowering, antidiabetic and anti-obesity effects. This review summarizes findings in the literature and highlights the therapeutic potential of betalains and their natural source as valid alternative for supplementation in obesity-related disorders treatment. Further research is needed to establish the mechanisms through which these natural pigments exert their beneficial effects and to translate the promising findings from animal models to humans.
C1 [Calvi, Pasquale; Terzo, Simona; Amato, Antonella] Univ Palermo Viale Sci, Dept Biol Chem Pharmaceut Sci & Technol STEBICEF, Palermo, Italy.
   [Calvi, Pasquale] Univ Palermo, Dipartment Biomed Neurosci & Adv Diagnost BiND, Palermo, Italy.
C3 University of Palermo; University of Palermo
RP Amato, A (corresponding author), Univ Palermo Viale Sci, Dept Biol Chem Pharmaceut Sci & Technol STEBICEF, Palermo, Italy.
EM antonella.amato@unipa.it
RI Amato, Antonella/AAX-8821-2020
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NR 99
TC 16
Z9 16
U1 2
U2 16
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1478-6419
EI 1478-6427
J9 NAT PROD RES
JI Nat. Prod. Res.
PD MAY 19
PY 2023
VL 37
IS 10
BP 1746
EP 1765
DI 10.1080/14786419.2022.2106481
EA JUL 2022
PG 20
WC Chemistry, Applied; Chemistry, Medicinal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Pharmacology & Pharmacy
GA E3EQ2
UT WOS:000836054200001
PM 35921318
DA 2025-06-11
ER

PT J
AU Niederseer, D
   Wernly, B
   Aigner, E
   Stickel, F
   Datz, C
AF Niederseer, David
   Wernly, Bernhard
   Aigner, Elmar
   Stickel, Felix
   Datz, Christian
TI NAFLD and Cardiovascular Diseases: Epidemiological, Mechanistic and
   Therapeutic Considerations
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Review
DE diabetes; metabolic syndrome; lifestyle; atherosclerosis; NASH; liver;
   exercise; nutrition
ID NONALCOHOLIC FATTY LIVER; STEATOHEPATITIS
AB Overwhelming evidence suggests an association of cardiovascular disease (CVD) with non-alcoholic fatty liver disease (NAFLD); however, the underlying mechanisms remain largely speculative. It is, however, likely that common mechanisms contribute to the development of CVD and NAFLD, with lifestyle factors such as smoking, sedentary lifestyle with poor nutrition habits and physical inactivity being major candidates. These behavioral factors, on a predisposing genetic background, trigger changes in gut microbiota, inflammation, dyslipidemia and oxidative stress, leading to metabolic syndrome, diabetes and obesity as well as atherosclerosis. Treatment options to counteract both the progression and development of CVD and NAFLD include lifestyle interventions, optimal medical therapy of comorbid conditions and, as final possibility, bariatric surgery. As no causal pharmacotherapy of NAFLD is available, further research is urgently needed to address the unmet need of a growing population with NAFLD and CVD.
C1 [Niederseer, David] Univ Zurich, Univ Heart Ctr Zurich, Univ Hosp Zurich, Dept Cardiol, CH-8091 Zurich, Switzerland.
   [Wernly, Bernhard] Paracelsus Med Univ Salzburg, Dept Anaesthesiol Perioperat Med & Intens Care Me, A-5020 Salzburg, Austria.
   [Wernly, Bernhard] Paracelsus Med Univ Salzburg, Ctr Publ Hlth & Healthcare Res, A-5020 Salzburg, Austria.
   [Wernly, Bernhard] Paracelsus Med Univ Salzburg, Dept Cardiol, A-5020 Salzburg, Austria.
   [Aigner, Elmar] Paracelsus Med Univ, Dept Med 1, A-5020 Salzburg, Austria.
   [Stickel, Felix] Univ Zurich, Univ Hosp Zurich, Dept Gastroenterol, CH-8091 Zurich, Switzerland.
   [Datz, Christian] Paracelsus Med Univ, Teaching Hosp, Gen Hosp Oberndorf, Dept Internal Med, A-5110 Oberndorf, Austria.
C3 University of Zurich; University Zurich Hospital; Paracelsus Private
   Medical University; Paracelsus Private Medical University; Paracelsus
   Private Medical University; Paracelsus Private Medical University;
   University of Zurich; University Zurich Hospital; Paracelsus Private
   Medical University
RP Datz, C (corresponding author), Paracelsus Med Univ, Teaching Hosp, Gen Hosp Oberndorf, Dept Internal Med, A-5110 Oberndorf, Austria.
EM david.niederseer@usz.ch; bernhard@wernly.net; e.aigner@salk.at;
   felix.stickel@uzh.ch; c.datz@kh-oberndorf.at
RI Wernly, Bernhard/AAA-8529-2020; Niederseer, David/X-7363-2018
OI Niederseer, David/0000-0003-3089-1222; Datz,
   Christian/0000-0001-7838-4532; Wernly, Bernhard/0000-0003-4024-0220
FU SPAR Austria AG
FX C.D. was funded by SPAR Austria AG.
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NR 30
TC 55
Z9 56
U1 1
U2 23
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD FEB
PY 2021
VL 10
IS 3
AR 467
DI 10.3390/jcm10030467
PG 23
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA QD2KS
UT WOS:000615354600001
PM 33530440
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Gómez-Guzmán, M
   Rodríguez-Nogales, A
   Algieri, F
   Gálvez, J
AF Gomez-Guzman, Manuel
   Rodriguez-Nogales, Alba
   Algieri, Francesca
   Galvez, Julio
TI Potential Role of Seaweed Polyphenols in Cardiovascular-Associated
   Disorders
SO MARINE DRUGS
LA English
DT Review
DE cardiovascular diseases; hypertension; immune response; metabolic
   syndrome; seaweed polyphenols
ID ALLEVIATES POSTPRANDIAL HYPERGLYCEMIA; REDUCING OXIDATIVE STRESS;
   UNDARIA-PINNATIFIDA WAKAME; ECKLONIA-CAVA; ALPHA-GLUCOSIDASE; BROWN
   SEAWEED; IN-VITRO; ANTIOXIDANT ACTIVITIES; INHIBITORY-ACTIVITY;
   PHENOLIC-COMPOUNDS
AB The beneficial effects of various polyphenols with plant origins on different cardiovascular-associated disorders, such as hypertension, diabetes mellitus type 2 and metabolic syndrome are well known. Recently, marine crude-drugs are emerging as potential treatments in many noncommunicable conditions, including those involving the cardiovascular system. Among the active compounds responsible for these activities, seaweed polyphenols seem to play a key role. The aim of the present review is to summarise the current knowledge about the beneficial effects reported for edible seaweed polyphenols in the amelioration of these prevalent conditions, focusing on both preclinical and clinical studies. This review will help to establish the basis for future studies in this promising field.
C1 [Gomez-Guzman, Manuel] Univ Granada, Sch Pharm, Dept Pharmacol, E-18071 Granada, Spain.
   [Gomez-Guzman, Manuel; Rodriguez-Nogales, Alba; Algieri, Francesca; Galvez, Julio] Inst Invest Biosanitaria Granada Ibs Granada, Granada 18071, Spain.
   [Rodriguez-Nogales, Alba; Algieri, Francesca; Galvez, Julio] Univ Granada, CIBER EHD, Dept Pharmacol, Ctr Biomed Res CIBM, E-18071 Granada, Spain.
C3 University of Granada; Instituto de Investigacion Biosanitaria IBS
   Granada; CIBER - Centro de Investigacion Biomedica en Red; CIBEREHD;
   University of Granada
RP Gálvez, J (corresponding author), Inst Invest Biosanitaria Granada Ibs Granada, Granada 18071, Spain.; Gálvez, J (corresponding author), Univ Granada, CIBER EHD, Dept Pharmacol, Ctr Biomed Res CIBM, E-18071 Granada, Spain.
EM mgguzman@ugr.es; albarnogales@gmail.com; fra.algieri@hotmail.it;
   jgalvez@ugr.es
RI Rodríguez-Nogales, Alba/J-2782-2017; Algieri, Francesca/J-4281-2017;
   Galvez, Julio/K-6875-2014; Gomez-Guzman, Manuel/E-3341-2012; Algieri,
   Francesca/L-3231-2014
OI Galvez, Julio/0000-0001-6876-3782; Gomez-Guzman,
   Manuel/0000-0003-2452-9286; Algieri, Francesca/0000-0002-0262-4867
FU Junta de Andalucia [CTS 164]; Spanish Ministry of Economy and
   Competitiveness [AGL2015-67995-C3-3-R]; European Union; Instituto de
   Salud Carlos III
FX This work was supported by the Junta de Andalucia (CTS 164) and by the
   Spanish Ministry of Economy and Competitiveness (AGL2015-67995-C3-3-R)
   with funds from the European Union. The CIBER-EHD is funded by the
   Instituto de Salud Carlos III.
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NR 133
TC 109
Z9 114
U1 2
U2 38
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1660-3397
J9 MAR DRUGS
JI Mar. Drugs
PD AUG
PY 2018
VL 16
IS 8
AR 250
DI 10.3390/md16080250
PG 21
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA HI8WP
UT WOS:000456736900003
PM 30060542
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Vágvölgyi, A
   Abrahám, JE
   Köteles, EM
   Korom, A
   Barnai, M
   Szücs, M
   Orosz, A
   Kempler, P
   Menyhart, A
   Nemes, A
   Várkonyi, T
   Baczko, I
   Kósa, I
   Lengyel, C
AF Vagvolgyi, Anna
   Abraham, Judit Erzsebet
   Koteles, Eva Mathene
   Korom, Andrea
   Barnai, Maria
   Szucs, Monika
   Orosz, Andrea
   Kempler, Peter
   Menyhart, Adrienn
   Nemes, Attila
   Varkonyi, Tamas
   Baczko, Istvan
   Kosa, Istvan
   Lengyel, Csaba
TI A three-month physical training program improves cardiovascular
   autonomic function in patients with metabolic syndrome with and without
   diabetes - a pilot study
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Article
DE autonomic function; cardiovascular; diabetes; metabolic syndrome;
   physical exercise
ID MULTIFACTORIAL INTERVENTION; OBESITY EPIDEMIC; UNITED-STATES;
   NEUROPATHY; DIAGNOSIS; DISEASE; GLUCOSE; IMPACT; RISK; DYSFUNCTION
AB Introduction: Vascular complications and neuropathy may develop in the presence of metabolic syndrome. The aim of our study was to measure the cardiovascular autonomic function following physical training in patients with metabolic syndrome with and without diabetes.
   Subjects and methods: 56 patients with metabolic syndrome (32 men/24 women, 40 non-diabetic patients (NDMetS)/16 diabetic patients (DMetS) [mean +/- SD]: age: 50.35 +/- 8.03 vs. 56.8 +/- 9.30 years, p=0.023; baseline BMI: 32.2 +/- 7.03 vs. 32.8 +/- 5.94 kg/m2, p=0.739) were involved in our study. All tests and measurements were carried out before and following a 3-month physical training period. Autonomic function was assessed by means of five standard cardiovascular reflex tests. ECG repolarization parameters, including short-term QT variability and stress-ECG were also measured.
   Results: In the whole population, Valsalva-ratio (VR) and the autonomic score (AS) improved following training (VR: 1.49 +/- 0.24 vs. 1.64 +/- 0.34, p=0.001; AS: 2.05 +/- 1.73 vs. 1.41 +/- 1.36, p=0.015) accompanied by the significant decrease of the systolic (150.3 +/- 16.12 vs. 134.1 +/- 16.67 mmHg, p<0.001) and diastolic (90.64 +/- 12.8 vs. 82.79 +/- 11.1 mmHg, p<0.001) blood pressure. An improvement in VR was detected in NDMetS patients following training (1.51 +/- 0.24 vs. 1.67 +/- 0.31, p= 0.002). No significant changes could be detected in autonomic tests' results in the DMetS patient group following training. The applied exercise training program did not lead to significant changes in ECG repolarization. The stress-ECG test in the whole study population yielded a significant increase in the test duration (12.9 +/- 3.76 vs. 15.1 +/- 2.96 min, p<0.001) and in the test load (10.5 +/- 2.78 vs. 11.6 +/- 2.39 MET, p<0.001). The load capability improved significantly in both subgroups: 11.1 +/- 2.04 vs. 12.1 +/- 1.82, (p<0.001) and 9.0 +/- 3.64 vs. 10.4 +/- 3.05, (p=0.033) in subpopulations of NDMetS and DMetS, respectively. The DMetS patients achieved a significantly lower MET score at baseline (p=0.039) and following training (p=0.044) in comparison to the NDMetS patients.
   Conclusion: The three-month exercise program improved the Valsalva-ratio and the AN score in the MetS patients, that is potentially protective against cardiovascular events. The training had some beneficial effect on blood pressure and the results of the stress-ECG tests in both groups. The absence of significant change in the reflex tests in DMetS group reflects an impaired adaptation compared to the NDMestS group.
C1 [Vagvolgyi, Anna; Nemes, Attila; Varkonyi, Tamas; Kosa, Istvan; Lengyel, Csaba] Univ Szeged, Albert Szent Gyorgy Med Sch, Dept Med, Szeged, Hungary.
   [Abraham, Judit Erzsebet; Kosa, Istvan] Univ Szeged, Albert Szent Gyorgy Med Sch, Dept Med Prevent, Szeged, Hungary.
   [Koteles, Eva Mathene; Korom, Andrea; Barnai, Maria] Univ Szeged, Fac Hlth Sci & Social Studies, Dept Physiotherapy, Szeged, Hungary.
   [Szucs, Monika] Univ Szeged, Albert Szent Gyorgy Med Sch, Dept Med Phys & Informat, Szeged, Hungary.
   [Orosz, Andrea; Baczko, Istvan] Univ Szeged, Albert Szent Gyorgy Med Sch, Dept Pharmacol & Pharmacotherapy, Szeged, Hungary.
   [Kempler, Peter; Menyhart, Adrienn] Semmelweis Univ, Dept Oncol & Internal Med, Budapest, Hungary.
C3 Szeged University; Szeged University; Szeged University; Szeged
   University; Szeged University; Semmelweis University
RP Nemes, A (corresponding author), Univ Szeged, Albert Szent Gyorgy Med Sch, Dept Med, Szeged, Hungary.
EM attila.nemes.md@gmail.com
RI Szucs, Monika/I-5292-2018; Baczko, István/I-7752-2019; Kósa,
   István/AHE-4081-2022
OI Szucs, Monika/0000-0002-8791-9452; Mathene Koteles,
   Eva/0000-0002-9728-5182; Baczko, Istvan/0000-0002-9588-0797
FU Supported by the Hungarian Diabetes Association, and the European Union,
   co-financed by the European Social Fund (EFOP-3.6.1-16-2016-00008 and
   EFOP-3.6.3-VEKOP-16-2017-00009) and by Project no.
   RRF-2.3.1-21-2022-00003 that has been implemented with the sup;
   Hungarian Diabetes Association [EFOP-3.6.3-VEKOP-16-2017-00009,
   RRF-2.3.1-21-2022-00003]; European Union - European Social Fund;
   European Union;  [EFOP-3.6.1-16-2016-00008]
FX Supported by the Hungarian Diabetes Association, and the European Union,
   co-financed by the European Social Fund (EFOP-3.6.1-16-2016-00008 and
   EFOP-3.6.3-VEKOP-16-2017-00009) and by Project no.
   RRF-2.3.1-21-2022-00003 that has been implemented with the support
   provided by the European Union.r Supported by the Hungarian Diabetes
   Association, and the European Union, co-financed by the European Social
   Fund (EFOP-3.6.1-16-2016-00008 and EFOP-3.6.3-VEKOP-16-2017-00009) and
   by Project no. RRF-2.3.1-21-2022-00003 that has been implemented with
   the support provided by the European Union.
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TC 4
Z9 4
U1 0
U2 0
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
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VL 14
AR 1224353
DI 10.3389/fendo.2023.1224353
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA Q6XS2
UT WOS:001058940200001
PM 37664832
OA gold, Green Accepted
DA 2025-06-11
ER

PT J
AU Mitchell, T
   Chacko, B
   Ballinger, SW
   Bailey, SM
   Zhang, JH
   Darley-Usmar, V
AF Mitchell, Tanecia
   Chacko, Balu
   Ballinger, Scott W.
   Bailey, Shannon M.
   Zhang, Jianhua
   Darley-Usmar, Victor
TI Convergent mechanisms for dysregulation of mitochondrial quality control
   in metabolic disease: implications for mitochondrial therapeutics
SO BIOCHEMICAL SOCIETY TRANSACTIONS
LA English
DT Article
DE alcoholic liver disease; cellular bioenergetics; diabetes; metabolic
   syndrome; mitochondria; mitoquinone (MitoQ); reserve respiratory
   capacity; steatosis
ID ANTIOXIDANT MITOQ PROTECTS; ALCOHOLIC LIVER-DISEASE; REACTIVE OXYGEN;
   HEPATOCELLULAR-CARCINOMA; SIGNAL-TRANSDUCTION; OXIDATIVE STRESS;
   NITRIC-OXIDE; RISK-FACTORS; ETHANOL; DYSFUNCTION
AB Mitochondrial dysfunction is associated with a broad range of pathologies including diabetes, ethanol toxicity, metabolic syndrome and cardiac failure. It is now becoming clear that maintaining mitochondrial quality through a balance between biogenesis, reserve capacity and mitophagy is critical in determining the response to metabolic or xenobiotic stress. In diseases associated with metabolic stress, such as Type II diabetes and non-alcoholic and alcoholic steatosis, the mitochondria are subjected to multiple 'hits' such as hypoxia and oxidative and nitrative stress, which can overwhelm the mitochondrial quality control pathways. In addition, the underlying mitochondrial genetics that evolved to accommodate high-energy demand, low-calorie supply environments may now be maladapted to modern lifestyles (low-energy demand, high-calorie environments). The pro-oxidant and pro-inflammatory environment of a sedentary western lifestyle has been associated with modified redox cell signalling pathways such as steatosis, hypoxic signalling, inflammation and fibrosis. These data suggest that loss of mitochondrial quality control is intimately associated with the aberrant activation of redox cell signalling pathways under pathological conditions. In the present short review, we discuss evidence from alcoholic liver disease supporting this concept, the insights obtained from experimental models and the application of bioenergetic-based therapeutics in the context of maintaining mitochondrial quality.
C1 [Mitchell, Tanecia; Chacko, Balu; Ballinger, Scott W.; Bailey, Shannon M.; Zhang, Jianhua; Darley-Usmar, Victor] Univ Alabama Birmingham, Dept Pathol, Birmingham, AL 35294 USA.
   [Mitchell, Tanecia; Chacko, Balu; Ballinger, Scott W.; Bailey, Shannon M.; Zhang, Jianhua; Darley-Usmar, Victor] Univ Alabama Birmingham, Ctr Free Radical Biol, Birmingham, AL 35294 USA.
   [Zhang, Jianhua] Univ Alabama Birmingham, Birmingham VA Med Ctr, Birmingham, AL 35294 USA.
C3 University of Alabama System; University of Alabama Birmingham;
   University of Alabama System; University of Alabama Birmingham; US
   Department of Veterans Affairs; Veterans Health Administration (VHA);
   Veterans Affairs Medical Center - Birmingham; University of Alabama
   System; University of Alabama Birmingham
RP Darley-Usmar, V (corresponding author), Univ Alabama Birmingham, Dept Pathol, Birmingham, AL 35294 USA.
EM darley@uab.edu
RI zhang, jianhua/D-3404-2009; Darley-Usmar, Victor/F-7656-2010
OI Zhang, Jianhua/0000-0002-2128-9574; Bailey, Shannon/0000-0003-0002-3424;
   Darley-Usmar, Victor/0000-0001-8921-7086
FU National Institutes of Health [T32 DK007545, HL 94518, HL 103859,
   DK073775, AA015172, AA018841, NS064090, AA13395]; VA merit award
FX This work was supported by National Institutes of Health [grant numbers
   T32 DK007545 (to T. M.), HL 94518 and HL 103859 (to S. B.), DK073775,
   AA015172 and AA018841 (to S. B.), NS064090 (to J.Z.), and AA13395 (to
   V.D.-U.)]. J.Z. was supported, in part, by a VA merit award.
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NR 61
TC 41
Z9 51
U1 0
U2 18
PU PORTLAND PRESS LTD
PI LONDON
PA CHARLES DARWIN HOUSE, 12 ROGER STREET, LONDON WC1N 2JU, ENGLAND
SN 0300-5127
EI 1470-8752
J9 BIOCHEM SOC T
JI Biochem. Soc. Trans.
PD FEB
PY 2013
VL 41
BP 127
EP 133
DI 10.1042/BST20120231
PN 1
PG 7
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 080EB
UT WOS:000314222900020
PM 23356271
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Bus, BAA
   Molendijk, ML
   Penninx, BJWH
   Buitelaar, JK
   Kenis, G
   Prickaerts, J
   Elzinga, BM
   Voshaar, RCO
AF Bus, B. A. A.
   Molendijk, M. L.
   Penninx, B. J. W. H.
   Buitelaar, J. K.
   Kenis, G.
   Prickaerts, J.
   Elzinga, B. M.
   Voshaar, R. C. Oude
TI Determinants of serum brain-derived neurotrophic factor
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE Brain-derived neurotrophic factor (BDNF); Determinant; Smoking;
   Sampling; Sociodemographic; Depression
ID FACTOR BDNF; METABOLIC SYNDROME; RAT-BRAIN; PHYSICAL-ACTIVITY;
   FEMALE-PATIENTS; HUMAN PLATELETS; MESSENGER-RNAS; GROWTH-FACTOR; FACTOR
   LEVEL; DEPRESSION
AB Background: Brain-derived neurotrophic factor (BDNF) belongs to the neurotrophin family of growth factors and affects the survival and plasticity of neurons in the adult central nervous system. The high correlation between cortical and serum BDNF levels has led to many human studies on BDNF levels in various populations, however knowledge about determinants that influence BDNF is lacking.
   Aims: To gain insight into the factors that influence BDNF levels in humans.
   Methods: In 1168 people aged 18 through 65, free of antidepressants and current psychiatric disease, from the Netherlands study of depression and anxiety four categories of determinants (sampling, sociodemographics, lifestyle indicators and diseases) were measured as well as BDNF level. We used univariate analyses as well as multivariate linear regression analyses in particular to determine which of the possible determinants significantly influenced serum BDNF levels.
   Results: The mean BDNF level was 8.98 ng/ml (SD 3.1 ng/ml) with a range from 1.56 ng/ml through 18.50 ng/ml. Our final multivariate regression analysis revealed that a non-fasting state of blood draw (beta = -.067; p = .019), later measurement (beta = -.065; p = .022), longer sample storage (beta = -.082; p = .004) and being a binge drinker (beta = -.063; p = .035) all resulted in attenuated BDNF levels. This was in contrast to smoking (beta = -.098; p = .001) and living in an urban area (beta = .109; p < .001), which resulted in increased BDNF levels. Moreover we found that older subjects also had higher BDNF levels, but this only applied to women (beta = .226; p < .001).
   Conclusions: Future studies on serum levels of BDNF in humans should correct for the time of blood withdrawal, storage, urbanicity, age, sex, smoking status and food and alcohol intake. (C) 2010 Elsevier Ltd. All rights reserved.
C1 [Bus, B. A. A.; Buitelaar, J. K.; Voshaar, R. C. Oude] Radboud Univ Nijmegen, Med Ctr, Dept Psychiat, NCEBP, NL-6525 GC Nijmegen, Netherlands.
   [Molendijk, M. L.; Elzinga, B. M.] Leiden Inst Psychol Res, Leiden, Netherlands.
   [Penninx, B. J. W. H.] Vrije Univ Amsterdam, Med Ctr, Dept Psychiat, Amsterdam, Netherlands.
   [Penninx, B. J. W. H.] Vrije Univ Amsterdam, Med Ctr, EMGO Inst, Amsterdam, Netherlands.
   [Penninx, B. J. W. H.] Leiden Univ, Med Ctr, Dept Psychiat, Leiden, Netherlands.
   [Penninx, B. J. W. H.] Univ Groningen, Univ Med Ctr Groningen, Dept Psychiat, NL-9713 AV Groningen, Netherlands.
   [Kenis, G.; Prickaerts, J.] Maastricht Univ, Sch Mental Hlth & Neurosci, Dept Psychiat & Neuropsychol, Maastricht, Netherlands.
   [Buitelaar, J. K.] Radboud Univ Nijmegen, Med Ctr, Dept Cognit Neurosci, NL-6525 GC Nijmegen, Netherlands.
C3 Radboud University Nijmegen; Vrije Universiteit Amsterdam; Vrije
   Universiteit Amsterdam; Leiden University - Excl LUMC; Leiden
   University; Leiden University Medical Center (LUMC); University of
   Groningen; Maastricht University; Radboud University Nijmegen
RP Bus, BAA (corresponding author), Radboud Univ Nijmegen, Med Ctr, Dept Psychiat, NCEBP, Reinier Postlaan 10, NL-6525 GC Nijmegen, Netherlands.
EM b.bus@psy.umcn.nl
RI Penninx, Brenda/S-7627-2017; Buitelaar, Jan/AAY-7522-2020
OI Kenis, Gunter/0000-0002-1263-0590; Oude Voshaar,
   Richard/0000-0003-1501-4774; Prickaerts, Jos/0000-0001-5548-731X
FU ZonMW, the Dutch Scientific Organisation-Medical Sciences [10.000.1002];
   GGZ Buitenamstel; GGZ Drenthe; GGZ Friesland; GGZ Geestgronden; GGZ
   Rivierduinen; Lentis; Leiden University Medical Center; University
   Medical Center Groningen; VU University Medical Center; NWO (Dutch
   Scientific Organisation) [016.085.353, 907.0023.1]
FX The NESDA study infrastructure is financed by the Geestkracht program of
   ZonMW, the Dutch Scientific Organisation-Medical Sciences (grant nr.
   10.000.1002) and by complementary funding from participating mental
   healthcare institutions (GGZ Buitenamstel, GGZ Drenthe, GGZ Friesland,
   GGZ Geestgronden, GGZ Rivierduinen, and Lentis) and Universities (Leiden
   University Medical Center, University Medical Center Groningen, and VU
   University Medical Center). BDNF measurements were financed with NWO
   (Dutch Scientific Organisation) VIDI-grant (grant nr. 016.085.353)
   awarded to Dr. Elzinga. Contribution of Dr. Oude Voshaar was made
   possible by a NWO Clinical Fellowship (grant nr. 907.0023.1).
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NR 75
TC 243
Z9 251
U1 0
U2 42
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD FEB
PY 2011
VL 36
IS 2
BP 228
EP 239
DI 10.1016/j.psyneuen.2010.07.013
PG 12
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA 727VL
UT WOS:000287830900009
PM 20702043
DA 2025-06-11
ER

PT J
AU Elseidy, AMA
   Bashandy, SA
   Ibrahim, FAA
   Abd El-Rahman, SS
   Farid, O
   Moussa, S
   El-Baset, MA
AF Elseidy, Ahmed M. A.
   Bashandy, Samir A.
   Ibrahim, Fatma A. A.
   Abd El-Rahman, Sahar S.
   Farid, Omar
   Moussa, Sherif
   El-Baset, Marwan A.
TI Zinc oxide nanoparticles characterization and therapeutic evaluation on
   high fat/sucrose diet induced-obesity
SO EGYPTIAN JOURNAL OF CHEMISTRY
LA English
DT Article
DE ZnO-Nps; Rietveld analysis; obesity; metabolic syndrome; inflammatory
   markers; oxidative stress
ID INSULIN-RESISTANCE; OXIDATIVE STRESS; METABOLIC SYNDROME;
   SUPPLEMENTATION; PATHOGENESIS; INFLAMMATION; ANTIOXIDANT; MECHANISMS;
   ADIPOKINES; CYTOKINES
AB ZnO/KCl nanocomposite was prepared by solgel to appreciate the role of synthesized ZnO-NPs to curb obesity in a high-fat diet rat model. KCl played an important role in decreasing the particle size (30 nm) and also in facilitating the suspension formation of ZnO-NPs. XRD and HRTEM were carried out to estimate the particle size while SEM was used to investigate the morphology of the nanoparticles. XPS measurements were used to examine the chemical compositions of the nanocomposite. XRD declared that ZnO has a hexagonal wurtzite structure. The Rietveld refinement has also been executed (chi(2) = 1.0 and R-factor was 0.05). The treatment of obese rats with ZnO-NPs enhanced the adiponectin level, hepatic carnitine (Car) and reduced hepatic glutathione (GSH) with lowering the liver enzymes and pathological changes. The treatment coused a decrease in body weight gain, Body mass index (BMI), leptin level, cholesterol, triglycerides, glucose, immunohistochemistry for nuclear factor kappa (NF kappa B), the insulin resistance index (HOMA-IR) and a reduction in hepatic malondialdehyde (MDA), nitric oxide (NO), and 8-Hydroxy-2'-deoxyguanosine (8OHdG). The results indicated a positive correlation between BMI and oxidative stress parameters. In conclusion, ZnO-NPs manifested valuable anti-obesity effects via lowering body weight gain, oxidative stress, BMI, lipids, and insulin resistance.
C1 [Elseidy, Ahmed M. A.] Natl Res Ctr, Inorgan Chem Dept, 33 El Bohouth St,PO 12622, Cairo, Egypt.
   [Bashandy, Samir A.; El-Baset, Marwan A.] Natl Res Ctr, Med Res & Clin Studies Inst, Pharmacol Dept, 33 El Bohouth St,PO 12622, Cairo, Egypt.
   [Ibrahim, Fatma A. A.; Moussa, Sherif] Natl Res Ctr, Biochem Dept, Biotechnol Inst, 33 EL BohouthSt, Cairo, Egypt.
   [Abd El-Rahman, Sahar S.] Cairo Univ, Fac Vet Med, Pathol Dept, Cairo, Egypt.
   [Farid, Omar] Natl Org Drug Control & Res, Cairo, Egypt.
C3 Egyptian Knowledge Bank (EKB); National Research Centre (NRC); Egyptian
   Knowledge Bank (EKB); National Research Centre (NRC); Egyptian Knowledge
   Bank (EKB); National Research Centre (NRC); Egyptian Knowledge Bank
   (EKB); Cairo University; National Organization for Drug Control &
   Research (NODCAR)
RP Elseidy, AMA (corresponding author), Natl Res Ctr, Inorgan Chem Dept, 33 El Bohouth St,PO 12622, Cairo, Egypt.
EM ahmedmaee2@gmail.com
RI El-Seidy, Ahmed/ABH-3277-2021; Ahmed-Farid, Omar/AAE-8278-2022; Sayed,
   Marawan/M-8214-2019
OI El-Seidy, Ahmed/0000-0003-0708-7658; Sayed, Marawan/0000-0002-0861-6251
FU National Research Centre, Cairo, Egypt [12060157]
FX This work is financially supported by National Research Centre, Cairo,
   Egypt (Project No 12060157)
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NR 59
TC 16
Z9 17
U1 0
U2 2
PU National Information & Documentation Centre-NIDOC
PI CAIRO
PA NIDOC DOKKI, CAIRO, 00000, EGYPT
SN 0449-2285
EI 2357-0245
J9 EGYPT J CHEM
JI Egypt. J. Chem.
PD SEP
PY 2022
VL 65
IS 9
BP 497
EP 511
DI 10.21608/EJCHEM.2022.112166.5113
PG 15
WC Chemistry, Multidisciplinary
WE Emerging Sources Citation Index (ESCI)
SC Chemistry
GA 1S4KZ
UT WOS:000804022400013
OA Bronze
DA 2025-06-11
ER

PT J
AU Malinska, H
   Skop, V
   Trnovska, J
   Markova, I
   Svoboda, P
   Kazdova, L
   Haluzik, M
AF Malinska, H.
   Skop, V.
   Trnovska, J.
   Markova, I.
   Svoboda, P.
   Kazdova, L.
   Haluzik, M.
TI Metformin Attenuates Myocardium Dicarbonyl Stress Induced by Chronic
   Hypertriglyceridemia
SO PHYSIOLOGICAL RESEARCH
LA English
DT Article
DE Hypertriglyceridemia; Dicarbonyl stress; Methylglyoxal; Glyoxalase;
   Metabolic syndrome; Metformin
ID METHYLGLYOXAL IMPAIRS; BETA-HYDROXYBUTYRATE; INSULIN-RESISTANCE;
   OXIDATIVE STRESS; ADIPOSE-TISSUE; GLYOXALASE; ACCUMULATION; MECHANISMS;
   GLYCATION; DISEASE
AB Reactive dicarbonyls stimulate production of advanced glycation endproducts, increase oxidative stress and inflammation and contribute to the development of vascular complications. We measured concentrations of dicarbonyls - methylglyoxal (MG), glyoxal (GL) and 3-deoxyglucosone (3-DG) - in the heart and kidney of a model of metabolic syndrome - hereditary hypertriglyceridemic rats (HHTg) and explored its modulation by metformin. Adult HHTg rats were fed a standard diet with or without metformin (300 mg/kg b.w.) and dicarbonyl levels and metabolic parameters were measured. HHTg rats had markedly elevated serum levels of triacylglycerols (p<0.001), FFA (p<0.01) and hepatic triacylglycerols (p<0.001) along with increased concentrations of reactive dicarbonyls in myocardium (MG: p<0.001; GL: p<0.01; 3-DG: p<0.01) and kidney cortex (MG: p<0.01). Metformin treatment significantly reduced reactive dicarbonyls in the myocardium (MG: p<0.05, GL: p<0.05, 3-DG: p<0.01) along with increase of myocardial concentrations of reduced glutathione (p<0.01) and glyoxalase 1 mRNA expression (p<0.05). Metformin did not have any significant effect on dicarbonyls, glutathione or on glyoxalase 1 expression in kidney cortex. Chronically elevated hypertriglyceridemia was associated with increased levels of dicarbonyls in heart and kidney. Beneficial effects of metformin on reactive dicarbonyls and glyoxalase in the heart could contribute to its cardioprotective effects.
C1 [Malinska, H.; Skop, V.; Trnovska, J.; Markova, I.; Kazdova, L.; Haluzik, M.] Inst Clin & Expt Med, Ctr Med Expt, Prague, Czech Republic.
   [Svoboda, P.] Univ Chem & Technol, Dept Biochem & Microbiol, Prague, Czech Republic.
C3 Institute for Clinical & Experimental Medicine (IKEM); University of
   Chemistry & Technology, Prague
RP Malinska, H (corresponding author), Inst Clin & Expt Med, Dept Cardiometab Res, Ctr Expt Med, Videnska 1958, Prague 14021 4, Czech Republic.
EM hana.malinska@ikem.cz
RI Svoboda, Petr/B-7865-2014; Skop, Vojtech/LBI-2231-2024
OI Markova, Irena/0000-0002-4331-7636; Skop, Vojtech/0000-0002-4685-4429;
   Trnovska, Jaroslava/0000-0001-6468-8244
FU Ministry of Health of the Czech Republic - conceptual development of
   research organizations ("Institute for Clinical and Experimental
   Medicine - IKEM") [IN 00023001]
FX This work was supported by the Ministry of Health of the Czech Republic
   - conceptual development of research organizations ("Institute for
   Clinical and Experimental Medicine - IKEM, IN 00023001").
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NR 32
TC 10
Z9 10
U1 0
U2 9
PU ACAD SCIENCES CZECH REPUBLIC, INST PHYSIOLOGY
PI PRAGUE 4
PA VIDENSKA 1083, PRAGUE 4 142 20, CZECH REPUBLIC
SN 0862-8408
EI 1802-9973
J9 PHYSIOL RES
JI Physiol. Res.
PY 2018
VL 67
IS 2
BP 181
EP 189
DI 10.33549/physiolres.933606
PG 9
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA GE7ZU
UT WOS:000431452400004
PM 29137475
OA gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Yang, X
   Feng, L
   Li, CJ
   Li, Y
AF Yang, Xuan
   Feng, Lei
   Li, Changjiang
   Li, Yu
TI Tranilast Alleviates Endothelial Dysfunctions and Insulin Resistance via
   Preserving Glutathione Peroxidase 1 in Rats Fed a High-Fat Emulsion
SO JOURNAL OF PHARMACOLOGICAL SCIENCES
LA English
DT Article
DE insulin resistance; oxidative stress; endothelial dysfunction;
   tranilast; metabolic syndrome
ID NITRIC-OXIDE SYNTHASE; MUSCLE GLUCOSE-UPTAKE; OXIDATIVE STRESS;
   METABOLIC SYNDROME; SKELETAL-MUSCLE; REACTIVE OXYGEN; VASCULAR
   DYSFUNCTIONS; WEIGHT-GAIN; MARKERS; ATHEROSCLEROSIS
AB We investigated the effects of treatment with tranilast on vascular and metabolic dysfunction induced by a high-fat emulsion intragastric administration. Wistar rats were randomized to receive water or high-fat emulsion with or without tranilast treatment (400 mg/kg per day) for 4 weeks. Insulin sensitivity was determined with a hyperinsulinemic-euglycemic clamp experiment and short insulin tolerance test. Vascular reactivity was evaluated using aortic rings in organ chambers. Glutathione peroxidase 1 (GPX1) expressions, eNOS phosphorylation and activity, MCP-1, H2O2 formation, and NO production were determined in vascular or soleus tissues. Tranilast treatment was found to prevent alterations in vascular reactivity and insulin sensitivity and to prevent increases in plasma glucose and insulin noted in the high-fat emulsion treated rats. These were associated with increased antioxidant enzyme GPX1 expression, eNOS phosphorylation and activity, and NO production, but reductions in H2O2 accumulation. Moreover, tranilast preserved GPX1 expression in palmitic acid (PA)-treated endothelial cells with a consequent decreased ROS formation and increased eNOS phosphorylation and NO production. Therefore, oxidative stress induced by a relatively short-term high-fat diet could cause the early development of vascular and metabolic abnormalities in rats, and tranilast has a beneficial effect in vascular dysfunctions and insulin resistance via preserving GPX1 and alleviating oxidative stress.
C1 [Yang, Xuan] Qingdao Municipal Hosp, Dept Cardiol, Qingdao 266000, Shandong, Peoples R China.
   [Feng, Lei] Qingdao Municipal Hosp, Diagnost Imaging Div, Qingdao 266000, Shandong, Peoples R China.
   [Li, Changjiang] Qingdao Cent Hosp, Intens Care Unit, Qingdao 266042, Shandong, Peoples R China.
   [Li, Yu] Zibo Municipal Hosp Author, Dept Internal Med, Zibo 255000, Shandong, Peoples R China.
C3 Qingdao Municipal Hospital; Qingdao Municipal Hospital
RP Yang, X (corresponding author), Qingdao Municipal Hosp, Dept Cardiol, Qingdao 266000, Shandong, Peoples R China.
EM yangxuan4040@163.com
RI Li, Changjiang/LEL-8637-2024
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NR 61
TC 8
Z9 10
U1 0
U2 10
PU JAPANESE PHARMACOLOGICAL SOC
PI KYOTO
PA EDITORIAL OFF, KANTOHYA BLDG GOKOMACHI-EBISUGAWA NAKAGYO-KU, KYOTO, 604,
   JAPAN
SN 1347-8613
EI 1347-8648
J9 J PHARMACOL SCI
JI J. Pharmacol. Sci.
PD JAN
PY 2014
VL 124
IS 1
BP 18
EP 30
DI 10.1254/jphs.13151FP
PG 13
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 299UT
UT WOS:000330421900003
PM 24389817
OA Bronze
DA 2025-06-11
ER

PT J
AU Ionita-Radu, F
   Ranetti, AE
   Vasile, TM
   Sirbu, AM
   Axelerad, A
   Sirbu, CA
AF Ionita-Radu, Florentina
   Ranetti, Aurelian E.
   Vasile, Titus M.
   Sirbu, Anca M.
   Axelerad, Any
   Sirbu, Carmen A.
TI The Impact of the Hypercaloric Diet versus the Mediterranean Diet on
   Insulin Sensitivity
SO ROMANIAN JOURNAL OF MILITARY MEDICINE
LA English
DT Article
DE obesity; diet; MetS; insulin; metaflammation
ID LOW-CARBOHYDRATE DIETS; METABOLIC SYNDROME; DIABETES-MELLITUS;
   RESISTANCE; OBESITY; PREVENTION; INTERVENTION; INFLAMMATION
AB Obesity affects the population worldwide. A hypercaloric diet associated with a sedentary life, stress, and genetic background, triggers various metabolic disorders, such as metabolic syndrome, diabetes mellitus, cancer, cardiovascular diseases, non-alcoholic fatty liver disease, and cognitive impairment. A healthy diet correlated with physical activity, not smoking, and moderate alcohol consumption reduces the risk of developing metabolic diseases. The Mediterranean diet contains antioxidants, fiber, polyunsaturated fats, and compounds with anti-inflammatory, anti-oxidant, anti-cancer, and anti-obesity properties. In a wide variety of species including humans, the reduction of calories between 20-40% significantly improves health, increases longevity, and delays the development of various pathologies. The main aim of this review is to present the comparative effects of the Mediterranean diet versus the hypercaloric diet on insulin sensitivity.
C1 [Ionita-Radu, Florentina] Carol Davila Cent Mil Emergency Univ Hosp, Gastroenterol Clin, Bucharest, Romania.
   [Ionita-Radu, Florentina] Carol Davila Univ Med & Pharm, Dept Internal Med & Gastroenterol, Bucharest, Romania.
   [Ranetti, Aurelian E.] Carol Davila Univ Med & Pharm, Dept Endocrinol, Bucharest, Romania.
   [Ranetti, Aurelian E.] Carol Davila Cent Mil Emergency Univ Hosp, Endocrinol Clin, Bucharest, Romania.
   [Vasile, Titus M.; Sirbu, Carmen A.] Univ Med & Pharm Carol Davila, Clin Neurosci Dept, Bucharest, Romania.
   [Sirbu, Anca M.] NovaLife Clin, Bucharest, Romania.
   [Axelerad, Any] Ovidius Univ, Gen Med Fac, Dept Neurol, Constanta, Romania.
   [Sirbu, Carmen A.] Dr Carol Davila Cent Mil Emergency Univ Hosp, Neurol Clin, Bucharest, Romania.
   [Sirbu, Carmen A.] Victor Babes Univ Med & Pharm, Fac Med, Ctr Cognit Res Neuropsychiat Pathol Neuropsy Cog, Dept Neurol, Timisoara, Romania.
C3 Carol Davila University of Medicine & Pharmacy; Carol Davila University
   of Medicine & Pharmacy; Carol Davila University of Medicine & Pharmacy;
   Ovidius University; Victor Babes University of Medicine & Pharmacy,
   Timisoara
RP Ranetti, AE (corresponding author), Carol Davila Univ Med & Pharm, Dept Endocrinol, Bucharest, Romania.; Ranetti, AE (corresponding author), Carol Davila Cent Mil Emergency Univ Hosp, Endocrinol Clin, Bucharest, Romania.
EM aurelian.ranetti@umfcd.ro
RI SIRBU, Carmen Adella/AAA-9317-2020; AXELERAD, ANY/F-5825-2012; Vasile,
   Mihai/G-3027-2011; Ionita-Radu, Florentina/ADP-0898-2022; Ranetti,
   Aurelian-Emil/JQV-7664-2023
OI Ranetti, Aurelian-Emil/0009-0006-1028-0618
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NR 62
TC 0
Z9 0
U1 0
U2 2
PU CAROL DAVILA UNIV MEDICINE & PHARMACY PUBL
PI BUCHAREST
PA STR INST MEDICO-MILITAR, NR 3-5, SECTOR 1, BUCHAREST, 010919, ROMANIA
SN 1222-5126
EI 2501-2312
J9 ROM J MIL MED
JI Rom. J. Milit. Med.
PD AUG
PY 2023
VL 126
IS 3
BP 275
EP 280
DI 10.55453/rjmm.2023.126.3.6
PG 6
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA T4AH1
UT WOS:001077425400005
DA 2025-06-11
ER

PT J
AU Omu, AE
AF Omu, Alexander E.
TI Sperm Parameters: Paradigmatic Index of Good Health and Longevity
SO MEDICAL PRINCIPLES AND PRACTICE
LA English
DT Review
DE Spermatozoa parameters; Longevity; Oxidative stress; Low testosterone
ID TESTICULAR DYSGENESIS SYNDROME; BODY-MASS INDEX; HORMONE-BINDING
   GLOBULIN; LIFE-STYLE FACTORS; SEMEN QUALITY; METABOLIC SYNDROME;
   OXIDATIVE STRESS; DNA-DAMAGE; TESTOSTERONE LEVELS; INSULIN-RESISTANCE
AB Since the discovery of spermatozoon by Anton van Leeuwenhoek in 1677, there has been an ever increasing understanding of its role in reproduction. Many factors adversely affect sperm quality, including varicocele, accessory gland infection, immunological factors, congenital abnormalities, and iatrogenic systemic and endocrine causes, such as diabetes mellitus, obesity, metabolic syndrome, and smoking. The mechanisms responsible for the association between poor sperm parameters and ill health may include oxidative stress, low-grade inflammation, low testosterone, and low sex-hormone-binding globulin. Oxidative stress in the testicular microenvironment may result in decreased spermatogenesis and sperm DNA damage, loss of sperm motility, and abnormal sperm morphology. Low testosterone caused by advanced age, visceral obesity, and inflammation is associated with the development of cardiovascular disease. Hence, semen analysis has an important role in the routine evaluation of idiopathic male infertility, usually manifested as low sperm counts, impaired sperm motility, or absence of sperm, and remains the most common single diagnostic tool. Several studies have shown an inverse relationship between semen quality and medical disorders. This review elucidates the effect of medical disorders and social habits on sperm quality, the mechanisms that are involved in the impairment of sperm quality, and whether or not sperm quality can be used as an index of good health and longevity in a man. (C) 2013 S. Karger AG, Basel
C1 Kuwait Univ, Fac Med, Dept Obstet & Gynecol, Hlth Sci Ctr, Safat 13110, Kuwait.
C3 Kuwait University
RP Omu, AE (corresponding author), Kuwait Univ, Fac Med, Dept Obstet & Gynecol, Hlth Sci Ctr, POB 24923, Safat 13110, Kuwait.
EM Omu@hsc.edu.kw
FU Research Sector, Kuwait University [MO031, 033, 254]
FX I am grateful to the Research Sector, Kuwait University, for research
   grants MO031, 033, and 254, which made this review possible. The
   technicians in my department and my medical colleagues and nurses at the
   Maternity Hospital worked with me with absolute dedication and
   professionalism. I acknowledge with gratitude the loyalty and
   contribution of all the patients from my clinic.
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NR 153
TC 42
Z9 45
U1 0
U2 16
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1011-7571
EI 1423-0151
J9 MED PRIN PRACT
JI Med. Princ. Pract.
PY 2013
VL 22
SU 1
BP 30
EP 42
DI 10.1159/000354208
PG 13
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 280UZ
UT WOS:000329057600005
PM 24051979
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Sud, N
   Taher, J
   Su, QZ
AF Sud, Neetu
   Taher, Jennifer
   Su, Qiaozhu
TI MicroRNAs and Noncoding RNAs in Hepatic Lipid and Lipoprotein
   Metabolism: Potential Therapeutic Targets of Metabolic Disorders
SO DRUG DEVELOPMENT RESEARCH
LA English
DT Review
DE noncoding RNAs; microRNAs; dyslipidemia; metabolic syndrome;
   drug-development
ID REVERSE CHOLESTEROL TRANSPORT; ENDOPLASMIC-RETICULUM STRESS;
   X-RECEPTOR-ALPHA; LXR-ALPHA; BINDING; EXPRESSION; PROTEIN; MIR-33; GENE;
   MITOCHONDRIAL
AB Noncoding RNAs and microRNAs (miRNAs) represent an important class of regulatory molecules that modulate gene expression. The role of miRNAs in diverse cellular processes such as cancer, apoptosis, cell differentiation, cardiac remodeling, and inflammation has been intensively explored. Recent studies further demonstrated the important roles of miRNAs and noncoding RNAs in modulating a broad spectrum of genes involved in lipid synthesis and metabolic pathways. This overview focuses on the role of miRNAs in hepatic lipid and lipoprotein metabolism and their potential as therapeutic targets for metabolic syndrome. This includes recent advances made in the understanding of their target pathways and the clinical development of miRNAs in lipid metabolic disorders. Drug Dev Res 76 : 318-327, 2015. (c) 2015 Wiley Periodicals, Inc.
C1 [Sud, Neetu; Su, Qiaozhu] Univ Nebraska, Dept Nutr & Hlth Sci, Lincoln, NE 68583 USA.
   [Taher, Jennifer] Hosp Sick Children, Res Inst, Program Mol Struct & Funct, Toronto, ON M5G 1X8, Canada.
   [Taher, Jennifer] Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON, Canada.
C3 University of Nebraska System; University of Nebraska Lincoln;
   University of Toronto; Hospital for Sick Children (SickKids); University
   of Toronto
RP Su, QZ (corresponding author), Univ Nebraska, 316F Leverton Hall, Lincoln, NE 68583 USA.
EM qsu2@unl.edu
RI Taher, Jennifer/GLV-4629-2022
OI Taher, Jennifer/0000-0001-9377-968X; Su, Qiaozhu/0000-0001-8434-1408
FU NIH [P20 GM104320-01A1]; Hatch funds from USDA/NIFA; Doctoral NSERC
   scholarship
FX This work was supported by a P20 GM104320-01A1 grant award from NIH, and
   Hatch funds from USDA/NIFA to Q.S. J.T. is supported by a Doctoral NSERC
   scholarship.
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NR 75
TC 21
Z9 24
U1 0
U2 10
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0272-4391
EI 1098-2299
J9 DRUG DEVELOP RES
JI Drug Dev. Res.
PD SEP
PY 2015
VL 76
IS 6
SI SI
BP 318
EP 327
DI 10.1002/ddr.21269
PG 10
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA CR2UG
UT WOS:000361185500007
PM 26286650
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Dorresteijn, JAN
   Visseren, FLJ
   Spiering, W
AF Dorresteijn, J. A. N.
   Visseren, F. L. J.
   Spiering, W.
TI Mechanisms linking obesity to hypertension
SO OBESITY REVIEWS
LA English
DT Article
DE Hypertension; metabolic syndrome; obesity; obesity-related hypertension
ID SYMPATHETIC-NERVE ACTIVITY; CARDIOVASCULAR RISK-FACTORS; BODY-MASS
   INDEX; CANNABINOID-1 RECEPTOR BLOCKER; ADIPOSE-TISSUE MASS; C-REACTIVE
   PROTEIN; BLOOD-PRESSURE; WEIGHT-LOSS; RESISTANT HYPERTENSION; METABOLIC
   SYNDROME
AB Obesity-related hypertension is increasingly recognized as a distinct hypertensive phenotype requiring a modified approach to diagnosis and management. In this review rapidly evolving insights into the complex and interdependent mechanisms linking obesity to hypertension are discussed. Overweight and obesity are associated with adipose tissue dysfunction, characterized by enlarged hypertrophied adipocytes, increased infiltration by macrophages and marked changes in secretion of adipokines and free fatty acids. This results in chronic vascular inflammation, oxidative stress, activation of the renin-angiotensin-aldosterone system and sympathetic overdrive, eventually leading to hypertension. These mechanisms may provide novel targets for anti-hypertensive drug treatment. Recognition of obesity-related hypertension as a distinct diagnosis enables tailored therapy in clinical practice. This includes lifestyle modification and accommodated choice of blood pressure-lowering drugs.
C1 [Dorresteijn, J. A. N.; Visseren, F. L. J.; Spiering, W.] Univ Med Ctr Utrecht, Dept Vasc Med, NL-3584 CX Utrecht, Netherlands.
C3 Utrecht University; Utrecht University Medical Center
RP Spiering, W (corresponding author), Univ Med Ctr Utrecht, Dept Vasc Med, Heidelberglaan 100, NL-3584 CX Utrecht, Netherlands.
EM w.spiering@umcutrecht.nl
RI Visseren, Frank/I-4855-2013
OI Spiering, Wilko/0000-0002-2493-6407; Visseren, Frank/0000-0003-3951-5223
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NR 113
TC 150
Z9 172
U1 0
U2 57
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1467-7881
EI 1467-789X
J9 OBES REV
JI Obes. Rev.
PD JAN
PY 2012
VL 13
IS 1
BP 17
EP 26
DI 10.1111/j.1467-789X.2011.00914.x
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 862LN
UT WOS:000298092500003
PM 21831233
DA 2025-06-11
ER

PT J
AU Murri, MB
   Pariante, C
   Mondelli, V
   Masotti, M
   Atti, AR
   Mellacqua, Z
   Antonioli, M
   Ghio, L
   Menchetti, M
   Zanetidou, S
   Innamorati, M
   Amore, M
AF Murri, Martino Belvederi
   Pariante, Carmine
   Mondelli, Valeria
   Masotti, Mattia
   Atti, Anna Rita
   Mellacqua, Zefiro
   Antonioli, Marco
   Ghio, Lucio
   Menchetti, Marco
   Zanetidou, Stamatula
   Innamorati, Marco
   Amore, Mario
TI HPA axis and aging in depression: Systematic review and meta-analysis
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Review
DE Cortisol; ACTH; CRH; Depression; Depressive symptoms; Elderly; Older
   adults; HPA axis; Dexamethasone; Antidepressant
ID DEXAMETHASONE-SUPPRESSION TEST; PITUITARY-ADRENAL AXIS; LATE-LIFE
   DEPRESSION; SALIVARY CORTISOL; MAJOR DEPRESSION; HYPERCORTISOLEMIC
   DEPRESSION; PSYCHOGERIATRIC POPULATION; GERIATRIC DEPRESSION;
   ALZHEIMERS-DISEASE; METABOLIC SYNDROME
AB One of the most consistent findings in the biology of depression is an altered activity of the hypothalamic pituitary adrenal (HPA) axis. However, data concerning this issue have never been examined with a focus on the older population. Here we present a systematic review and meta-analysis, based on studies investigating levels of cortisol, adrenocorticotropic hormone (ACTH) and corticotropin-releasing hormone (CRH) in depressed participants older than 60 and compared with healthy controls. We found 20 studies, for a total of 43 comparisons on different indices of HPA axis functioning. Depression had a significant effect (Hedges' g) on basal cortisol levels measured in the morning (0.89), afternoon (0.83) and night (1.39), but a smaller effect on cortisol measured continuously (0.51). The effect of depression was even higher on postdexamethasone cortisol levels (3.22), whereas it was non-significant on morning ACTH and CRH levels. Subgroup analyses indicated that various methodological and clinical factors can influence the study results. Overall, older participants suffering from depression show a high degree of dysregulation of HPA axis activity, with differences compared with younger adults. This might depend on several mechanisms, including physical illnesses, alterations in the CNS and immune-endocrinological alterations. Further studies are needed to clarify the implications of altered HPA axis activity in older patients suffering from depression. Novel pharmacological approaches might be effective in targeting this pathophysiological feature, thus improving the clinical outcomes. (C) 2013 Elsevier Ltd. All rights reserved.
C1 [Murri, Martino Belvederi; Pariante, Carmine; Mondelli, Valeria] Kings Coll London, Dept Psychol Med, Inst Psychiat, London SE5 9NU, England.
   [Murri, Martino Belvederi; Innamorati, Marco] Univ Parma, Div Psychiat, Dept Neurosci, I-43100 Parma, Italy.
   [Masotti, Mattia; Ghio, Lucio; Amore, Mario] Univ Genoa, Dept Neurosci Oftalmol Genet & Infant Maternal Sc, Sect Psychiat, Genoa, Italy.
   [Atti, Anna Rita; Antonioli, Marco] Univ Bologna, Dept Biomed & NeuroMotor Sci Psychiat, I-40126 Bologna, Italy.
   [Mellacqua, Zefiro] Kings Coll London, Dept Psychosis Studies, Inst Psychiat, London SE5 9NU, England.
   [Menchetti, Marco] Univ Bologna, Dept Med & Surg Sci, Sect Psychiat, I-40126 Bologna, Italy.
   [Zanetidou, Stamatula] AUSL Bologna, Dept Mental Hlth, Bologna, Italy.
C3 University of London; King's College London; University of Parma;
   University of Genoa; University of Bologna; University of London; King's
   College London; University of Bologna; AUSL di Bologna
RP Murri, MB (corresponding author), Kings Coll London, James Black Ctr, Dept Psychol Med, Sect Perinatal Psychiat & Stress,Inst Psychiat, Room 2-055,125 Coldharbour Lane, London SE5 9NU, England.
EM martino.belvederi@gmail.com
RI Mondelli, Valeria/K-8988-2016; Atti, Anna/AAP-7878-2020; Altamura,
   Mario/IQS-2773-2023; Innamorati, Marco/H-8877-2013; Pariante, Carmine
   Maria/B-1297-2011; Belvederi Murri, Martino/G-8781-2011
OI Mondelli, Valeria/0000-0001-8690-6839; Innamorati,
   Marco/0000-0003-1389-2290; Pariante, Carmine Maria/0000-0002-9132-5091;
   Belvederi Murri, Martino/0000-0002-7262-3528
FU Medical Research Council [G108/603] Funding Source: Medline; MRC
   [G108/603] Funding Source: UKRI
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   Young EA, 2004, FRONT NEUROENDOCRIN, V25, P69, DOI 10.1016/j.yfrne.2004.07.001
   Zunszain PA, 2011, PROG NEURO-PSYCHOPH, V35, P722, DOI 10.1016/j.pnpbp.2010.04.011
NR 97
TC 256
Z9 273
U1 0
U2 56
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD MAR
PY 2014
VL 41
BP 46
EP 62
DI 10.1016/j.psyneuen.2013.12.004
PG 17
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA AB8PR
UT WOS:000332053000005
PM 24495607
DA 2025-06-11
ER

PT J
AU Sangeetha, A
   Bobby, Z
   Wadwekar, V
   Nisha, Y
AF Sangeetha, A.
   Bobby, Zachariah
   Wadwekar, Vaibhav
   Nisha, Yadav
TI Atherogenic Risk Factors among Young Indian Adults with Epilepsy on
   Treatment with Phenytoin: Need for Novel Therapeutic Strategies
SO NEUROLOGY INDIA
LA English
DT Article
DE Dyslipidemia; metabolic syndrome; oxidative stress; phenytoin; systemic
   inflammation
ID SERUM-LIPID PROFILE; OXIDATIVE STRESS; ANTIEPILEPTIC DRUGS;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; ANTIOXIDANT; SENSITIVITY;
   HOMEOSTASIS; EXTRACT; RATS
AB Background: Risk for the development of coronary heart disease and diabetes is found to be more among people with epilepsy especially when on treatment. Redox imbalance contributes to this risk especially in India as it is the diabetic capital of the world with higher prevalence of inflammation.
   Objectives: The aim of this study was to evaluate atherogenic risk factors; dyslipidemia, oxidative stress, and systemic inflammation among young Indian adults with epilepsy on treatment with Phenytoin.
   Material and Methods: Three groups of age and gender-matched young subjects were recruited. Group 1-Healthy control subjects, Group 2-Newly diagnosed epileptic young adults with recent epileptic seizures, Group 3-Epileptic adults on treatment with Phenytoin for more than 6 months were recruited.
   Results: Dyslipidemia was found among the newly diagnosed epileptic subjects in comparison to healthy subjects. The LDL-cholesterol further increased, and HDL-cholesterol further decreased in the third group treated with Phenytoin. Body mass index of these treated epileptic subjects was more in comparison to healthy control. Low-grade inflammation as assessed by hsCRP and oxidative stress were significantly higher among the newly diagnosed epileptic subjects when compared to the healthy controls which further increased on treatment with phenytoin. We found dyslipidemia, oxidative stress, and low-grade inflammation among newly diagnosed epileptic subjects which further increased on treatment with Phenytoin for more than 6 months.
   Conclusion: From this study, we conclude that dyslipidemia, oxidative stress and low-grade inflammation are identified among the newly diagnosed young adult Indian epileptic patients. Phenytoin treatment further augmented these complications.
C1 [Sangeetha, A.; Bobby, Zachariah; Nisha, Yadav] Jawaharlal Inst Postgrad Med Educ & Res, Dept Biochem, Pondicherry, India.
   [Wadwekar, Vaibhav] Jawaharlal Inst Postgrad Med Educ & Res, Dept Neurol, Pondicherry, India.
C3 Jawaharlal Institute of Postgraduate Medical Education & Research;
   Jawaharlal Institute of Postgraduate Medical Education & Research
RP Bobby, Z (corresponding author), JIPMER, Dept Biochem, Pondicherry 605006, India.
EM zacbobby@yahoo.com
RI Zachariah, Bobby/IUQ-0806-2023; Wadwekar, Vaibhav/AAD-4191-2021
FU JIPMER, Puducherry, India
FX This study was carried with the intramural funds received from JIPMER,
   Puducherry-6, India.
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NR 31
TC 5
Z9 5
U1 0
U2 1
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, Maharashtra, INDIA
SN 0028-3886
EI 1998-4022
J9 NEUROL INDIA
JI Neurol. India
PD JUL-AUG
PY 2021
VL 69
IS 4
BP 957
EP 961
AR PMID 34507420
DI 10.4103/0028-3886.325371
PG 5
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA YY8JS
UT WOS:000755032000032
PM 34507420
DA 2025-06-11
ER

PT J
AU Galili, O
   Versari, D
   Sattler, KJ
   Olson, ML
   Mannheim, D
   McConnell, JP
   Chade, AR
   Lerman, LO
   Lerman, A
AF Galili, Offer
   Versari, Daniele
   Sattler, Katherine J.
   Olson, Monica L.
   Mannheim, Dallit
   McConnell, Joseph P.
   Chade, Alejandro R.
   Lerman, Lilach O.
   Lerman, Amir
TI Early experimental obesity is associated with coronary endothelial
   dysfunction and oxidative stress
SO AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
LA English
DT Article
DE endothelium; vasodilation; permeability; leptin
ID INSULIN-RESISTANCE; METABOLIC SYNDROME; NITRIC-OXIDE; EXPERIMENTAL
   HYPERCHOLESTEROLEMIA; INDUCED HYPERTENSION; CARDIOVASCULAR RISK;
   RECEPTOR ANTAGONISM; VASCULAR-DISEASE; BLOOD-PRESSURE; LEPTIN
AB Obesity is independently associated with increased cardiovascular risk. However, since established obesity clusters with various cardiovascular risk factors, configuring the metabolic syndrome, the early effects of obesity on vascular function are still poorly understood. The current study was designed to evaluate the effect of early obesity on coronary endothelial function in a new animal model of swine obesity. As to method, juvenile domestic crossbred pigs were randomized to either high-fat/high-calorie diet (HF) or normal chow diet for 12 wk. Coronary microvascular permeability and abdominal wall fat were determined by using electron beam computerized tomography. Epicardial endothelial function and oxidative stress were measured in vitro. Systemic oxidative stress, renin-angiotensin activity, leptin levels, and parameters of insulin sensitivity were evaluated. As a result, HF pigs were characterized by abdominal obesity, hypertension, and elevated plasma lysophosphatidylcholine and leptin in the presence of increased insulin sensitivity. Coronary endothelium-dependent vasorelaxation was reduced in HF pigs and myocardial microvascular permeability increased compared with those values in normal pigs. Systemic redox status in HF pigs was similar to that in normal pigs, whereas the coronary endothelium demonstrated higher content of superoxide anions, nitrotyrosine, and NADPH-oxidase subunits, indicating increased tissue oxidative stress. In conclusion, the current study shows that early obesity is characterized by increased vascular oxidative stress and endothelial dysfunction in association with increased levels of leptin and before the development of insulin resistance and systemic oxidative stress. Vascular dysfunction is therefore an early manifestation of obesity and might contribute to the increased cardiovascular risk, independently of insulin resistance.
C1 Mayo Clin, Coll Med, Dept Cardiovasc Dis, Div Cardiovasc Dis, Rochester, MN 55905 USA.
   Mayo Clin, Coll Med, Dept Lab Med & Pathol, Rochester, MN 55905 USA.
   Mayo Clin, Coll Med, Dept Hypertens & Nephrol, Rochester, MN 55905 USA.
C3 Mayo Clinic; Mayo Clinic; Mayo Clinic
RP Lerman, A (corresponding author), Mayo Clin, Coll Med, Dept Cardiovasc Dis, Div Cardiovasc Dis, 200 1st St SW, Rochester, MN 55905 USA.
EM lerman.amir@mayo.edu
RI Lerman, Lilach/M-4962-2017
OI /0000-0003-3175-3972
FU NHLBI NIH HHS [K-24-HL-69840-02, R01-HL-63911, R01-HL-77131] Funding
   Source: Medline
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NR 59
TC 150
Z9 169
U1 0
U2 5
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0363-6135
EI 1522-1539
J9 AM J PHYSIOL-HEART C
JI Am. J. Physiol.-Heart Circul. Physiol.
PD FEB
PY 2007
VL 292
IS 2
BP H904
EP H911
DI 10.1152/ajpheart.00628.2006
PG 8
WC Cardiac & Cardiovascular Systems; Physiology; Peripheral Vascular
   Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Physiology
GA 134FK
UT WOS:000244068700022
PM 17012356
DA 2025-06-11
ER

PT J
AU Rangel-Huerta, OD
   Pastor-Villaescusa, B
   Gil, A
AF Rangel-Huerta, Oscar Daniel
   Pastor-Villaescusa, Belen
   Gil, Angel
TI Are we close to defining a metabolomic signature of human obesity? A
   systematic review of metabolomics studies
SO METABOLOMICS
LA English
DT Review
DE Metabolomics; Obesityand overweight; Metabolic profiling; Weight loss;
   Dietary intervention
ID BODY-MASS INDEX; CARDIOMETABOLIC RISK-FACTORS; VISCERAL ADIPOSE-TISSUE;
   TRIMETHYLAMINE-N-OXIDE; CORONARY-HEART-DISEASE; FATTY-ACID-COMPOSITION;
   INSULIN-RESISTANCE; WEIGHT-LOSS; AMINO-ACID; BRANCHED-CHAIN
AB IntroductionObesity is a disorder characterized by a disproportionate increase in body weight in relation to height, mainly due to the accumulation of fat, and is considered a pandemic of the present century by many international health institutions. It is associated with several non-communicable chronic diseases, namely, metabolic syndrome, type 2 diabetes mellitus (T2DM), cardiovascular diseases (CVD), and cancer. Metabolomics is a useful tool to evaluate changes in metabolites due to being overweight and obesity at the body fluid and cellular levels and to ascertain metabolic changes in metabolically unhealthy overweight and obese individuals (MUHO) compared to metabolically healthy individuals (MHO).ObjectivesWe aimed to conduct a systematic review (SR) of human studies focused on identifying metabolomic signatures in obese individuals and obesity-related metabolic alterations, such as inflammation or oxidative stress.MethodsWe reviewed the literature to identify studies investigating the metabolomics profile of human obesity and that were published up to May 7th, 2019 in SCOPUS and PubMed through an SR. The quality of reporting was evaluated using an adapted of QUADOMICS.ResultsThirty-three articles were included and classified according to four types of approaches. (i) studying the metabolic signature of obesity, (ii) studying the differential responses of obese and non-obese subjects to dietary challenges (iii) studies that used metabolomics to predict weight loss and aimed to assess the effects of weight loss interventions on the metabolomics profiles of overweight or obese human subjects (iv) articles that studied the effects of specific dietary patterns or dietary compounds on obesity-related metabolic alterations in humans.ConclusionThe present SR provides state-of-the-art information about the use of metabolomics as an approach to understanding the dynamics of metabolic processes involved in human obesity and emphasizes metabolic signatures related to obesity phenotypes.
C1 [Rangel-Huerta, Oscar Daniel] Univ Oslo, Dept Nutr, Fac Med, Oslo, Norway.
   [Rangel-Huerta, Oscar Daniel] Norwegian Vet Inst, Oslo, Norway.
   [Pastor-Villaescusa, Belen] Univ Munich, Med Ctr, LMU Ludwig Maximilians Univ Munchen, Div Metab & Nutr Med,Dr von Hauner Childrens Hosp, Munich, Germany.
   [Pastor-Villaescusa, Belen] Helmholtz Zentrum Munchen, Inst Epidemiol, German Res Ctr Environm Hlth, Neuherberg, Germany.
   [Gil, Angel] Univ Granada, Inst Nutr & Food Technol Jose Mataix, Dept Biochem & Mol Biol 2, Ctr Biomed Res, Granada, Spain.
   [Gil, Angel] Inst Invest Biosanitaria Ibs Granada, Granada, Spain.
   [Gil, Angel] Physiopathol Obes & Nutr Networking Biomed Res Ct, Madrid, Spain.
C3 University of Oslo; Norwegian Veterinary Institute; University of
   Munich; Helmholtz Association; Helmholtz-Center Munich - German Research
   Center for Environmental Health; University of Granada; Instituto de
   Investigacion Biosanitaria IBS Granada
RP Gil, A (corresponding author), Univ Granada, Inst Nutr & Food Technol Jose Mataix, Dept Biochem & Mol Biol 2, Ctr Biomed Res, Granada, Spain.; Gil, A (corresponding author), Inst Invest Biosanitaria Ibs Granada, Granada, Spain.; Gil, A (corresponding author), Physiopathol Obes & Nutr Networking Biomed Res Ct, Madrid, Spain.
EM agil@ugr.es
RI Rangel-Huerta, Oscar/Q-7804-2018; Pastor-Villaescusa,
   Belén/GRF-0832-2022; Rangel Huerta, Oscar Daniel/I-4019-2015; Pastor
   Villaescusa, Belen/U-2325-2017; Gil, Angel/L-2275-2014
OI Rangel Huerta, Oscar Daniel/0000-0001-8585-0108; Pastor Villaescusa,
   Belen/0000-0003-0817-6804; Gil, Angel/0000-0001-7663-0939
FU European Union [609020]; Alfonso Martin Escudero Foundation, Spain
FX ODRH has received funding from the European Union Seventh Framework
   Programme (FP7-PEOPLE-2013-COFUND) under grant agreement no 609020 -
   Scientia Fellows. BPV is supported by a grant to postdoctoral
   researchers at foreign universities and research centers from the
   Alfonso Martin Escudero Foundation, Spain.
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NR 198
TC 159
Z9 173
U1 2
U2 42
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1573-3882
EI 1573-3890
J9 METABOLOMICS
JI Metabolomics
PD JUN
PY 2019
VL 15
IS 6
AR 93
DI 10.1007/s11306-019-1553-y
PG 31
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA ID3ZI
UT WOS:000471615200001
PM 31197497
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Ballesteros, MN
   Valenzuela, F
   Robles, AE
   Artalejo, E
   Aguilar, D
   Andersen, CJ
   Valdez, H
   Fernandez, ML
AF Nydia Ballesteros, Martha
   Valenzuela, Fabrizio
   Robles, Alma E.
   Artalejo, Elizabeth
   Aguilar, David
   Andersen, Catherine J.
   Valdez, Herlindo
   Fernandez, Maria Luz
TI One Egg per Day Improves Inflammation when Compared to an Oatmeal-Based
   Breakfast without Increasing Other Cardiometabolic Risk Factors in
   Diabetic Patients
SO NUTRIENTS
LA English
DT Article
ID DIETARY-CHOLESTEROL; CARBOHYDRATE RESTRICTION; INSULIN-RESISTANCE; LDL
   CHOLESTEROL; HDL CHOLESTEROL; CONSUMPTION; LUTEIN; BIOAVAILABILITY;
   POPULATION; METABOLISM
AB There is concern that egg intake may increase blood glucose in patients with type 2 diabetes mellitus (T2DM). However, we have previously shown that eggs reduce inflammation in patients at risk for T2DM, including obese subjects and those with metabolic syndrome. Thus, we hypothesized that egg intake would not alter plasma glucose in T2DM patients when compared to oatmeal intake. Our primary endpoints for this clinical intervention were plasma glucose and the inflammatory markers tumor necrosis factor (TNF)-alpha and interleukin 6 (IL-6). As secondary endpoints, we evaluated additional parameters of glucose metabolism, dyslipidemias, oxidative stress and inflammation. Twenty-nine subjects, 35-65 years with glycosylated hemoglobin (HbA1c) values <9% were recruited and randomly allocated to consume isocaloric breakfasts containing either one egg/day or 40 g of oatmeal with 472 mL of lactose-free milk/day for five weeks. Following a three-week washout period, subjects were assigned to the alternate breakfast. At the end of each period, we measured all primary and secondary endpoints. Subjects completed four-day dietary recalls and one exercise questionnaire for each breakfast period. There were no significant differences in plasma glucose, our primary endpoint, plasma lipids, lipoprotein size or subfraction concentrations, insulin, HbA1c, apolipoprotein B, oxidized LDL or C-reactive protein. However, after adjusting for gender, age and body mass index, aspartate amino-transferase (AST) (p < 0.05) and tumor necrosis factor (TNF)-alpha (p < 0.01), one of our primary endpoints were significantly reduced during the egg period. These results suggest that compared to an oatmeal-based breakfast, eggs do not have any detrimental effects on lipoprotein or glucose metabolism in T2DM. In contrast, eggs reduce AST and TNF-alpha in this population characterized by chronic low-grade inflammation.
C1 [Nydia Ballesteros, Martha; Valenzuela, Fabrizio; Robles, Alma E.; Artalejo, Elizabeth] CIAD, Hermosillo 83304, Sonora, Mexico.
   [Aguilar, David; Andersen, Catherine J.; Fernandez, Maria Luz] Univ Connecticut, Dept Nutr Sci, Storrs, CT 06269 USA.
   [Valdez, Herlindo] Hosp Ignacio Chavez, Hermosillo 83190, Sonora, Mexico.
C3 CIAD - Centro de Investigacion en Alimentacion y Desarrollo; University
   of Connecticut
RP Fernandez, ML (corresponding author), Univ Connecticut, Dept Nutr Sci, Storrs, CT 06269 USA.
EM nydia@ciad.mx; fabe_vi@hotmail.com; melina@ciad.mx; eartalejo@ciad.mx;
   david_178@hotmail.com; candersen@fairfield.edu; herlindov@yahoo.com.mx;
   maria-luz.fernandez@uconn.edu
RI ; Robles-Sardin, Alma-Elizabeth/M-7714-2015
OI Andersen, Catherine/0000-0001-9774-5030; Fernandez,
   Maria-Luz/0000-0002-1835-0792; Robles-Sardin,
   Alma-Elizabeth/0000-0003-2044-7793
FU Egg Nutrition Center
FX Supported by the Egg Nutrition Center from funds received by M.L.F.
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NR 40
TC 63
Z9 73
U1 0
U2 29
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD MAY
PY 2015
VL 7
IS 5
BP 3449
EP 3463
DI 10.3390/nu7053449
PG 15
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA CK5CT
UT WOS:000356240500023
PM 25970149
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Gupta, P
   Mehla, J
   Siddique, K
   Jamil, S
   Gupta, YK
AF Gupta, Pooja
   Mehla, Jogender
   Siddique, Khalid
   Jamil, Shakir
   Gupta, Yogendra Kumar
TI Anti-oxidant and Anti-inflammatory activity of Safoof Mohazzil: A
   traditional, Poly-herbal Unani formulation for Obesity
SO INDIAN JOURNAL OF TRADITIONAL KNOWLEDGE
LA English
DT Article
DE Safoof Mohazzil; Obesity; Inflammation; Oxidative stress; Metabolic
   syndrome
ID LIPID-PEROXIDATION; OXIDATIVE STRESS; POLYHERBAL FORMULATION;
   FREE-RADICALS; INFLAMMATION; DAMAGE; ASSAY
AB Inflammation and oxidative stress have been reported in obesity. Safoof Mohazzil, is a traditional formulation prescribed by Unani physicians for weight loss. In the present study, antioxidant and anti-inflammatory properties of Safoof Mohazzil were evaluated using pyrogallol induced hepatotoxicity and carrageenan induced paw edema, respectively, in male Wistar rats. For the antioxidant study, rats were treated with Safoof Mohazzil for 14 days at the doses of 250, 500 and 1000 mg/kg, p.o. On 14th day, 2 hrs after the last dose of Unani formulation, pyrogallol (100 mg/kg) was injected intraperitoneally and on next day the animals were sacrificed for estimation of hepatic oxidative stress markers (malondialdehyde and reduced glutathione). Safoof Mohazzil demonstrated dose-dependent anti-oxidant activity. To assess its anti-inflammatory property, Safoof Mohazzil was administered at the doses of 500 & 1000 mg/kg, p.o. for 7 days and on 7th day carrageenan was administered 1 hr after the last dose of Unani formulation. The change in paw volume was calculated at 1, 3 and 6 hrs. Significant anti-inflammatory activity was found at 1000 mg/kg dose which is the human equivalent of its anti-obesity dose. The antioxidant and anti-inflammatory activity of Safoof Mohazzil support its use in obesity and possibly metabolic syndrome.
C1 [Gupta, Pooja; Mehla, Jogender; Gupta, Yogendra Kumar] All India Inst Med Sci, Dept Pharmacol, New Delhi 110029, India.
   [Siddique, Khalid; Jamil, Shakir] Govt India, Minist Hlth & Family Welf, Cent Council Res Unani Med, Dept Ayurveda Yoga Unani Siddha & Homeopathy, New Delhi, India.
C3 All India Institute of Medical Sciences (AIIMS) New Delhi
RP Gupta, YK (corresponding author), All India Inst Med Sci, Dept Pharmacol, R 4012,4th Floor Teaching Block, New Delhi 110029, India.
EM drgupta.pooja@gmail.com; yk.ykgupta@gmail.com
RI Mehla, Jogender/M-1055-2019
OI Gupta, Pooja/0000-0002-3687-3853
FU Central Council for Research in Unani Medicine (CCRUM), Department of
   Ayurveda, Yoga and Naturopathy, Unani, Siddha and Homoeopathy (AYUSH),
   Ministry of Health & Family Welfare, Government of India
FX The study was funded by Central Council for Research in Unani Medicine
   (CCRUM), Department of Ayurveda, Yoga and Naturopathy, Unani, Siddha and
   Homoeopathy (AYUSH), Ministry of Health & Family Welfare, Government of
   India. The Unani formulation was prepared by National Institute of
   Nutrition, Hyderabad, India for CCRUM. Mr Ritesh Kumar and Ms Shalu
   Arora assisted in execution of the study.
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PU NATL INST SCIENCE COMMUNICATION-NISCAIR
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PA DR K S KRISHNAN MARG, PUSA CAMPUS, NEW DELHI 110 012, INDIA
SN 0972-5938
EI 0975-1068
J9 INDIAN J TRADIT KNOW
JI Indian J. Tradit. Knowl.
PD JUL
PY 2015
VL 14
IS 3
BP 461
EP 465
PG 5
WC Plant Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences
GA CT0EZ
UT WOS:000362468000020
DA 2025-06-11
ER

PT J
AU Kase, NG
   Friedman, EG
   Brodman, M
   Kang, CF
   Gallagher, EJ
   LeRoith, D
AF Kase, Nathan G.
   Friedman, Elissa Gretz
   Brodman, Michael
   Kang, Chifei
   Gallagher, Emily J.
   LeRoith, Derek
TI The midlife transition and the risk of cardiovascular disease and cancer
   Part I: magnitude and mechanisms
SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
LA English
DT Review
DE aging; cancer; coronary artery disease; diabetes type 2; dyslipidemia;
   estradiol; hormone therapy; insulin resistance; menopause; midlife
   transition; metabolic syndrome; steroid and insulin receptors; systemic
   inflammatory state; visceral adiposity; waist circumference; window of
   opportunity
ID CORONARY-HEART-DISEASE; POSTMENOPAUSAL HORMONE-THERAPY; ESTROGEN PLUS
   PROGESTIN; BODY-MASS INDEX; BREAST-CANCER; WOMENS HEALTH; METABOLIC
   SYNDROME; DIABETES-MELLITUS; INSULIN-RECEPTOR; UNITED-STATES
AB Heart disease and cancer are the leading causes of death in the United States. In women, the clinical appearance of both entities-coronary heart disease and cancer (breast, endometrium, and ovary)-escalate during the decades of the midlife transition encompassing the menopause. In addition to the impact of aging, during the interval between the age of 40 and 65 years, the pathophysiologic components of metabolic syndrome also emerge and accelerate. These include visceral adiposity (measured as waist circumference), hypertension, diabetes, and dyslipidemia. Osteoporosis, osteoarthritis, sarcopenia, depression, and even cognitive decline and dementia appear, and most, if not all, are considered functionally related. Two clinical reports confirm the interaction linking the emergence of disease: endometrial cancer and metabolic syndrome. One describes the discovery of unsuspected endometrial cancer in a large series of elective hysterectomies performed in aged and metabolically susceptible populations. The other is from the Women's Health Initiative Observational Study, which found a positive interaction between endometrial cancer and metabolic syndrome regardless of the presence or absence of visceral adiposity. Both provide additional statistical support for the long-suspected causal interaction among the parallel but variable occurrence of these common entities-visceral obesity, heart disease, diabetes, cancer, and the prevalence of metabolic syndrome. Therefore, 2 critical clinical questions require analysis and answers:
   1: Why do chronic diseases of adulthood-metabolic, cardiovascular, endocrine- and, in women, cancers of the breast and endometrium (tissues and tumors replete with estrogen receptors) emerge and their incidence trajectories accelerate during the postmenopausal period when little or no endogenous estradiol is available, and yet the therapeutic application of estrogen stimulates their appearance?
   2: To what extent should identification of these etiologic driving forces require modification of the gynecologist's responsibilities in the care of our patients in the postreproductive decades of the female life cycle?
   Part I of this 2-part set of "expert reviews" defines the dimensions, gravity, and interactive synergy of each clinical challenge gynecologists face while caring for their midlife (primarily postmenopausal) patients. It describes the clinically identifiable, potentially treatable, pathogenic mechanisms driving these threats to quality of life and longevity.
   Part 2 (accepted, American Journal of Obstetrics & Gynecology) identifies 7 objectives of successful clinical care, offers "triage" prioritization targets, and provides feasible opportunities for insertion of primary preventive care initiatives. To implement these goals, a reprogrammed, repurposed office visit is described.YY
C1 [Kase, Nathan G.; Friedman, Elissa Gretz; Brodman, Michael] Icahn Sch Med Mt Sinai, Dept Obstet Gynecol & Reprod Sci, New York, NY 10029 USA.
   [Kase, Nathan G.; Kang, Chifei; Gallagher, Emily J.; LeRoith, Derek] Icahn Sch Med Mt Sinai, Dept Med, Div Endocrinol Diabet & Bone Dis, New York, NY 10029 USA.
C3 Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at
   Mount Sinai
RP Kase, NG (corresponding author), Icahn Sch Med Mt Sinai, Dept Obstet Gynecol & Reprod Sci, New York, NY 10029 USA.; Kase, NG (corresponding author), Icahn Sch Med Mt Sinai, Dept Med, Div Endocrinol Diabet & Bone Dis, New York, NY 10029 USA.
EM nathan.kase@mssm.edu
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NR 136
TC 16
Z9 17
U1 1
U2 13
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0002-9378
EI 1097-6868
J9 AM J OBSTET GYNECOL
JI Am. J. Obstet. Gynecol.
PD DEC
PY 2020
VL 223
IS 6
BP 820
EP 833
DI 10.1016/j.ajog.2020.05.051
PG 14
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA PL4EX
UT WOS:000603078300017
PM 32497614
DA 2025-06-11
ER

PT J
AU Leu, S
   Wu, KLH
   Lee, WC
   Tain, YL
   Chan, JYH
AF Leu, Steve
   Wu, Kay L. H.
   Lee, Wei-Chia
   Tain, You-Lin
   Chan, Julie Y. H.
TI Maternal Fructose Intake Exacerbates Cardiac Remodeling in Offspring
   with Ventricular Pressure Overload
SO NUTRIENTS
LA English
DT Article
DE maternal fructose exposure; developmental programming; cardiac
   hypertrophy; oxidative stress; transverse aortic constriction
ID NUTRIENT RESTRICTION; INSULIN-RESISTANCE; METABOLIC SYNDROME; DIETARY
   FRUCTOSE; OXIDATIVE STRESS; HYPERTROPHY; HYPERTENSION; OBESITY;
   EXPRESSION; RECEPTORS
AB Recent studies demonstrated that metabolic syndrome and cardiovascular diseases could be elicited by developmental programming, which is regulated by prenatal nutritional and environmental stress. In this study, we utilized a rat model to examine the effect of excessive maternal fructose intake during pregnancy and lactation on cardiac development and progression of pressure overload-induced cardiac hypertrophy in offspring. Transverse aortic constriction (TAC) was performed on 3-month-old male offspring to induce ventricular pressure overload. Four weeks post-TAC, echocardiographic assessment as well as histopathological and biochemical examinations were performed on the myocardium of the offspring. Echocardiographic and gross examinations showed that heart weight, interventricular septal thickness in diastole (IVD; d), and left ventricular posterior wall thickness in diastole (LVPW; d) were elevated in offspring with TAC and further increased by maternal fructose exposure (MFE). However, the left ventricular ejection function was not significantly affected. Myocardial histopathological examination revealed that the indices of fibrosis and oxidative stress were higher in offspring with MFE and TAC than those in animals receiving either treatment. Molecular examinations on the myocardium demonstrated an MFE-induced upregulation of p38-MAPK signaling. Next generation sequence (NGS) analysis indicated a modulation of the expression levels of several cardiac hypertrophy-associated genes, including GPR22, Myh7, Nppa, P2RX4, and Npy by MFE. Subsequent RT-PCR indicated that MFE regulated the expression levels of genes responsive to cardiac hypertrophy (i.e., Myh-7, ANP) and oxidative stress (i.e., GR, GPx, and NQO-1). In conclusion, MFE during pregnancy and lactation modulated myocardial gene expression, increased oxidative stress, and exacerbated ventricular pressure overload-induced cardiac remodeling in rat offspring.
C1 [Leu, Steve; Wu, Kay L. H.; Tain, You-Lin; Chan, Julie Y. H.] Kaohsiung Chang Gung Mem Hosp, Inst Translat Res Biomed, Kaohsiung 833401, Taiwan.
   [Leu, Steve] Kaohsiung Med Univ, Dept Biotechnol, Coll Life Sci, Kaohsiung 807378, Taiwan.
   [Lee, Wei-Chia] Chang Gung Univ, Dept Urol, Kaohsiung Chang Gung Mem Hosp, Kaohsiung 833401, Taiwan.
   [Lee, Wei-Chia; Tain, You-Lin] Chang Gung Univ, Coll Med, Kaohsiung 833401, Taiwan.
   [Tain, You-Lin] Chang Gung Univ, Kaohsiung Chang Gung Mem Hosp, Dept Pediat, Kaohsiung 833401, Taiwan.
C3 Chang Gung Memorial Hospital; Kaohsiung Medical University; Chang Gung
   Memorial Hospital; Chang Gung Memorial Hospital
RP Leu, S; Chan, JYH (corresponding author), Kaohsiung Chang Gung Mem Hosp, Inst Translat Res Biomed, Kaohsiung 833401, Taiwan.
EM leu@mail.cgu.edu.tw; wlh0701@yahoo.com.tw; dinor666@ms32.hinet.net;
   tainyl@hotmail.com; jchan@adm.cgmh.org.tw
RI Wu, Kay/ACD-1767-2022; Chan, Julie/X-5253-2019; Tain,
   You-Lin/H-2827-2019; Leu, Steve/D-6807-2011
OI Chan, Julie Y.H./0000-0001-8036-4645; Tain, You-Lin/0000-0002-7059-6407;
   Lee, Wei-Chia/0000-0003-0701-2285; Leu, Steve/0000-0002-1738-1028; Wu,
   Kay L.H./0000-0002-7297-6788
FU Chang Gung Medical Research Program Grant [CMRPG 8F0041, 8F0042,
   8F0043]; Ministry of Science and Technology, Taiwan [MOST
   109-2320-B-182A-009]
FX This research was Chang Gung Medical Research Program Grant (Grant
   number: CMRPG 8F0041, 8F0042, 8F0043) and from Ministry of Science and
   Technology, Taiwan (MOST 109-2320-B-182A-009).
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NR 39
TC 5
Z9 5
U1 1
U2 6
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD SEP
PY 2021
VL 13
IS 9
AR 3267
DI 10.3390/nu13093267
PG 13
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA UY6JG
UT WOS:000701627300001
PM 34579143
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Harman-Boehm, I
AF Harman-Boehm, I
TI The patient with unstable angina: no evidence of MI
SO ACTA DIABETOLOGICA
LA English
DT Article
DE diabetes mellitus; ischemic heart disease; angina pectoris
AB A 53-year-old type 2 diabetic woman with macrovascular complications as well as the components of the metabolic syndrome presents with an unstable angina and ST depression on electromiogram. The negative impact of female gender, microvascular complications, and metabolic parameters on cardiovascular risk and prognosis, are emphasized. The lack of evidence for hormone replacement, antioxidant or universal folic acid therapy is underscored. Treatment options including PTCA and stenting augmented with low molecular weight heparin, clopidrogel and IIb/IIIa antagonists as well as optimal metabolic control are discussed.
C1 Soroka Hosp, Beer Sheva, Israel.
C3 Ben-Gurion University of the Negev; Soroka Medical Center
RP Harman-Boehm, I (corresponding author), Soroka Hosp, Beer Sheva, Israel.
NR 0
TC 0
Z9 0
U1 0
U2 1
PU SPRINGER-VERLAG
PI NEW YORK
PA 175 FIFTH AVE, NEW YORK, NY 10010 USA
SN 0940-5429
J9 ACTA DIABETOL
JI Acta Diabetol.
PD DEC
PY 2003
VL 40
SU 2
BP S407
EP S408
DI 10.1007/s00592-003-0128-5
PG 2
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 758HP
UT WOS:000187628600017
PM 14704877
DA 2025-06-11
ER

PT J
AU Walker, BR
   Seckl, JR
AF Walker, BR
   Seckl, JR
TI 11β-hydroxysteroid dehydrogenase Type 1 as a novel therapeutic target in
   metabolic and neurodegenerative disease
SO EXPERT OPINION ON THERAPEUTIC TARGETS
LA English
DT Review
DE 11 beta-hydroxysteroid dehydrogenase Type I (11HSD1); cognitive
   impairment no dementia; glucocordcoids; hypertension; metabolic syndrome
ID BETA-HYDROXYSTEROID DEHYDROGENASE; GUINEA-PIG KIDNEY; SELECTIVE
   GLUCOCORTICOID MODULATORS; CORTISONE REDUCTASE DEFICIENCY; HEPATIC
   INSULIN SENSITIVITY; MESSENGER-RIBONUCLEIC-ACID; ADIPOSE STROMAL CELLS;
   BODY-FAT DISTRIBUTION; CARDIOVASCULAR RISK; BLOOD-PRESSURE
AB 11beta-Hydroxysteroid dehydrogenase Type 1 (11HSD1) catalyses regeneration of active 11-hydroxy glucocorticoids from inactive 11-keto metabolites within target tissues. Inhibition of 11HSD1 has been proposed as a novel strategy to lower intracellular glucocorticoid concentrations, without affecting circulating glucocorticoid levels and their responsiveness to stress. Increased 11HSD1 activity may be pathogenic, for example, in adipose tissue in obesity. Experiments in transgenic mice and using prototype inhibitors in humans show benefits of 11HSD1 inhibition in liver, adipose and brain tissue in treating features of the metabolic syndrome and cognitive dysfunction with ageing. The clinical development of potent selective 11HSD1 inhibitors is now a high priority.
C1 Univ Edinburgh, Western Gen Hosp, Endocrinol Unit, Edinburgh EH4 2XU, Midlothian, Scotland.
C3 University of Edinburgh
RP Univ Edinburgh, Western Gen Hosp, Endocrinol Unit, Edinburgh EH4 2XU, Midlothian, Scotland.
EM B.Walker@ed.ac.uk
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NR 136
TC 54
Z9 60
U1 0
U2 4
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1472-8222
EI 1744-7631
J9 EXPERT OPIN THER TAR
JI Expert Opin. Ther. Targets
PD DEC
PY 2003
VL 7
IS 6
BP 771
EP 783
DI 10.1517/eott.7.6.771.22573
PG 13
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 754LN
UT WOS:000187318800007
PM 14640912
DA 2025-06-11
ER

PT J
AU Roohafza, H
   Kabir, A
   Sadeghi, M
   Shokouh, P
   Aalaei-Andabili, SH
   Mehrabi, Y
   Sarrafzadegan, N
AF Roohafza, Hamidreza
   Kabir, Ali
   Sadeghi, Masoumeh
   Shokouh, Pedram
   Aalaei-Andabili, Seyed Hossein
   Mehrabi, Yadollah
   Sarrafzadegan, Nizal
TI Effect of Psychological Distress on Weight Concern and Weight Control
   Behaviors
SO ARCHIVES OF IRANIAN MEDICINE
LA English
DT Article
DE Iran; obesity; psychological distress; weight concern; weigh control
   behavior
ID STRESS-RELATED CHANGES; JOB STRAIN; METABOLIC SYNDROME;
   PHYSICAL-ACTIVITY; BODY-MASS; OBESITY; PREVALENCE; ASSOCIATIONS;
   ADOLESCENTS; PERCEPTION
AB Background: Obesity is associated with chronic disorders like coronary artery diseases, metabolic syndrome, cancers, and psychiatric disorders. Stress may contribute to weight gain by disrupting weight concern, and lead to uncontrolled eating behavior. This study aimed to investigate the effects-of stress on weight concern-and control behaviour in normal Weight and obese adults.
   Methods: A total 9544-subjects were selected by multi-stage random sampling-from three provinces in central Iran. Information related to weight concern and control behavior was registered in normal weight and obese participants. Psychological distress was measured by a 12-item General Health Questionnaire (GHQ-12) and subjects were divided into high and low-stress groups. Logistic regression:was used for analysis.
   Results: The mean age of participants Was 38.7 +/- 15.5 years and 50% (4772) of them were males. The adjusted odds ratio (OR) for age, sex and education of high stress to low stress level for weight concern, weight Control behavior and acceptable physical activity behavior was more than 1; but the CA was less than 1 for waist circumference, obesity and,healthy diet-behavior. Among obese participants, higher levels of stress were associated with lower weight concern with OR, 95%Cl: 0.821, (0.682 +/- 0.988), lower acceptable physical-activity with OR = 0.833, 95%Cl: (0.624 +/- 0912), but higher rates of healthy diet behavior with OR = 1.360, 95% Cl: (1.040-1.780).
   Conclusion: Individuals with high stress level have lower weight concern and lower physical activity; therefore, they are probe to weight gain and obesity. It-could be concluded that stress management should be considered as a crucial component of obesity prevention and control programs.
C1 [Roohafza, Hamidreza] Isfahan Univ Med Sci, Isfahan Cardiovasc Res Inst, Isfahan Cardiovasc Res Ctr, Dept Mental Hlth, Esfahan, Iran.
   [Kabir, Ali] Iran Univ Med Sci, Minimally Invas Surg Res Ctr, Tehran, Iran.
   [Kabir, Ali] Shahid Beheshti Univ Med Sci, Dept Epidemiol, Sch Publ Hlth, Tehran, Iran.
   [Sadeghi, Masoumeh] Isfahan Univ Med Sci, Isfahan Cardiovasc Res Inst, Cardiac Rehabil Res Ctr, Esfahan, Iran.
   [Shokouh, Pedram] Isfahan Univ Med Sci, Isfahan Cardiovasc Res Inst, Hypertens Res Ctr, Esfahan, Iran.
   [Aalaei-Andabili, Seyed Hossein] Nikan Hlth Researchers Inst, Tehran, Iran.
   [Mehrabi, Yadollah] Shahid Beheshti Univ Med Sci, Dept Epidemiol, Sch Publ Hlth, Tehran, Iran.
   [Sarrafzadegan, Nizal] Isfahan Univ Med Sci, Isfahan Cardiovasc Res Inst, Isfahan Cardiovasc Res Ctr, Esfahan, Iran.
C3 Isfahan University of Medical Sciences; Iran University of Medical
   Sciences; Shahid Beheshti University Medical Sciences; Isfahan
   University of Medical Sciences; Isfahan University of Medical Sciences;
   Shahid Beheshti University Medical Sciences; Isfahan University of
   Medical Sciences
RP Sadeghi, M (corresponding author), Isfahan Univ Med Sci, Isfahan Cardiovasc Res Inst, Cardiac Rehabil Res Ctr, WHO Collaborating Ctr Res & Training Cardiovasc D, POB 81465-1148, Esfahan, Iran.
EM aikabir@yahoo.com; m_sadeghi@crc.mui.ac.ir
RI Kabir, A./M-5979-2016; Sadeghi, Masoumeh/W-2291-2017; Shokouh,
   Pedram/AAX-4572-2021; Sarrafzadegan, Nizal/V-5826-2017; Mehrabi,
   Yadollah/J-4211-2016; Mehrabi, Yadollah/J-4211-2016
OI Sadeghi Mahonak, Masoumeh/0000-0001-7179-5558; Roohafza,
   Hamidreza/0000-0003-3582-0431; Sarrafzadegan, Nizal/0000-0002-8352-0540;
   Mehrabi, Yadollah/0000-0001-9837-4956; Mehrabi,
   Yadollah/0000-0001-8555-6160
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NR 46
TC 4
Z9 6
U1 0
U2 17
PU ACAD MEDICAL SCIENCES I R IRAN
PI TEHRAN
PA PO BOX 19395-5655, TEHRAN, 00000, IRAN
SN 1029-2977
EI 1735-3947
J9 ARCH IRAN MED
JI Arch. Iran. Med.
PD SEP
PY 2014
VL 17
IS 9
BP 608
EP 612
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA AQ2GL
UT WOS:000342603700003
PM 25204476
DA 2025-06-11
ER

PT J
AU Yasui, T
   Okada, A
   Hamamoto, S
   Ando, R
   Taguchi, K
   Tozawa, K
   Kohri, K
AF Yasui, Takahiro
   Okada, Atsushi
   Hamamoto, Shuzo
   Ando, Ryosuke
   Taguchi, Kazumi
   Tozawa, Keiichi
   Kohri, Kenjiro
TI Pathophysiology-based treatment of urolithiasis
SO INTERNATIONAL JOURNAL OF UROLOGY
LA English
DT Review
DE calcium oxalate; kidney calculi; mitochondria; nephrolithiasis;
   oxidative stress; urolithiasis
ID CALCIUM-OXALATE MONOHYDRATE; TUBULAR EPITHELIAL-CELLS; RENAL CRYSTAL
   DEPOSITION; KIDNEY-STONE FORMATION; METABOLIC SYNDROME; OXIDATIVE
   STRESS; VASCULAR CALCIFICATION; EICOSAPENTAENOIC ACID; JAPANESE
   POPULATION; URINARY-EXCRETION
AB Urolithiasis, a complex multifactorial disease, results from interactions between environmental and genetic factors. Epidemiological studies have shown the association of urolithiasis with a number of lifestyle-related diseases, including cardiovascular diseases, hypertension, chronic kidney disease, diabetes and metabolic syndrome. Elucidation of the mechanisms underlying urinary stone formation will enable development of new preventive treatments. The present article reviews the epidemiology, pathophysiology and potential treatment of urolithiasis. Recent literature has shown that oxidative stress and reactive oxygen species could be one such mechanistic pathway. Calcium oxalate crystals adhering to renal tubular cells are incorporated into the cells through the involvement of osteopontin. Stimulation of crystal-cell adhesion impairs acceleration of the mitochondrial permeability transition pore in tubular cells, resulting in mitochondrial collapse, oxidative stress and activation of the apoptotic pathway in the initial steps of renal calcium crystallization. With regard to genetic factors, studies show that single nucleotide polymorphisms in genes encoding calcium-sensing receptor, vitamin D receptor and osteopontin are correlated with urolithiasis. Genome-wide association studies have shown that CLDN14 and NPT2 are associated with urolithiasis in Caucasian and Japanese populations, respectively. Thus, single nucleotide polymorphism analysis would aid in the prediction of urolithiasis risk and recurrence. New diagnostic methods and preventive approaches, along with complete removal of stones, will improve the management of urolithiasis.
C1 [Yasui, Takahiro; Okada, Atsushi; Hamamoto, Shuzo; Ando, Ryosuke; Taguchi, Kazumi; Tozawa, Keiichi; Kohri, Kenjiro] Nagoya City Univ, Grad Sch Med Sci, Dept Nephrourol, Nagoya, Aichi, Japan.
C3 Nagoya City University
RP Yasui, T (corresponding author), Nagoya City Univ, Grad Sch Med Sci, Dept Nephrourol, Mizuho Ku, 1 Kawasumi,Mizuho Cho, Nagoya, Aichi 4678601, Japan.
EM yasui@med.nagoya-cu.ac.jp
RI YASUI, Takahiro/E-6401-2018; Taguchi, Kazumi/AFU-4486-2022
OI Yasui, Takahiro/0000-0003-2197-2477; Taguchi, Kazumi/0000-0002-3092-5114
FU Ministry of Education, Culture, Science and Technology [16790922,
   18791132, 20591887, 23592375, 23249074, 24659716, 24592434, 25462520,
   25670685, 15K10627]; Takeda Science Foundation; Japanese Urological
   Association; Grants-in-Aid for Scientific Research [24659716, 25462520,
   15K10627, 20591887, 23249074, 18791132, 24592434, 16790922, 23592375,
   25670685] Funding Source: KAKEN
FX This work was supported by Grants-in-Aid from the Ministry of Education,
   Culture, Science and Technology (16790922, 18791132, 20591887, 23592375,
   23249074, 24659716, 24592434, 25462520, 25670685, 15K10627); the Takeda
   Science Foundation; and the Japanese Urological Association.
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NR 78
TC 73
Z9 81
U1 1
U2 12
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0919-8172
EI 1442-2042
J9 INT J UROL
JI Int. J. Urol.
PD JAN
PY 2017
VL 24
IS 1
BP 32
EP 38
DI 10.1111/iju.13187
PG 7
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA EJ6BY
UT WOS:000393304700005
PM 27539983
OA Bronze
DA 2025-06-11
ER

PT J
AU Diaz-Gerevini, GT
   Repossi, G
   Dain, A
   Tarres, MC
   Das, UN
   Eynard, AR
AF Tomas Diaz-Gerevini, Gustavo
   Repossi, Gaston
   Dain, Alejandro
   Cristina Tarres, Maria
   Das, Undurti Narasimha
   Renato Eynard, Aldo
TI Beneficial action of resveratrol: How and why?
SO NUTRITION
LA English
DT Review
DE Resveratrol; Flavonoids; Type 2 diabetes mellitus; Obesity; Alzheimer's
   disease; Microbiota
ID ENDOPLASMIC-RETICULUM STRESS; INSULIN-RESISTANCE; MOUSE MODEL;
   INDUCTION; AUTOPHAGY; SIRT1; APOPTOSIS; AUTISM; NANOPARTICLES;
   INHIBITION
AB Flavonoid resveratrol modulates the transcription factor NF-kappa B; inhibits the cytochrome P450 isoenzyme CYP1 A1; suppresses the expression and activity of cyclooxygenase enzymes; and modulates Fas/Fas-ligand-mediated apoptosis, p53, mammalian target of rapamycin, and cyclins and various phosphodiesterases. This increases the cytosolic cAMP that activates Epac1/CaMKK beta/AMPK/SIRT1/PGC-1 alpha a pathway, which in turn facilitates increased oxidation of fatty acids, mitochondria) biogenesis, mitochondrial respiration, and gluconeogenesis. Resveratrol triggers apoptosis of activated T cells and suppresses tumor necrosis factor-alpha, interluekin-17 (IL-17), and other proinflammatory molecules, and thus is of benefit in autoimmune diseases. In addition, resveratrol inhibits expression of hypoxia-inducible factor-1 alpha and vascular endothelial growth factor, explaining its effective action against cancer. Brain-derived neurotrophic factor (BDNF) that is involved in the pathogenesis of obesity, type 2 diabetes mellitus, and metabolic syndrome is also altered in depression, schizophrenia, bipolar disorder, and autism. We noted that BDNF protects against cytotoxic actions of alloxan, streptozotocin, and benzo(a)pyrene. Resveratrol prevents bisphenol A-induced autism, type 2 diabetes mellitus, and metabolic syndrome, suggesting that it may augment BDNF synthesis and action. We also observed that BDNF levels are low in type 2 diabetes mellitus and that BDNF enhances production of antiinflammatory lipid, lipoxin A4, whose levels are low in diabetes mellitus. Thus, resveratrol may augment production of lipoxin A4. Resveratrol alters gut microbiota and influences stem cell proliferation and differentiation. These pleiotropic actions of resveratrol may explain the multitude of its actions and benefits. (C) 2016 Elsevier Inc. All rights reserved.
C1 [Tomas Diaz-Gerevini, Gustavo; Repossi, Gaston; Dain, Alejandro; Renato Eynard, Aldo] Univ Nacl Cordoba, Biol Celular Histol & Embriol, Fac Ciencias Med, INICSA,CONICET, RA-5000 Cordoba, Argentina.
   [Repossi, Gaston] Univ Nacl Rioja, Catedra Histol Embriol & Genet, La Rioja, Argentina.
   [Repossi, Gaston; Cristina Tarres, Maria; Renato Eynard, Aldo] Consejo Nacl Invest Cient & Tecn, Cordoba, Argentina.
   [Cristina Tarres, Maria] Univ Nacl Rosario, Fac Ciencias Med, RA-2000 Rosario, Santa Fe, Argentina.
   [Das, Undurti Narasimha] GVP Hosp, Dept Med, Campus Gayatri Vidya Parishad Coll Engn, Visakhapatnam, Andhra Pradesh, India.
   [Das, Undurti Narasimha] BioSci Res Ctr, Campus Gayatri Vidya Parishad Coll Engn, Visakhapatnam, Andhra Pradesh, India.
   [Das, Undurti Narasimha] UND Life Sci, Fed Way, Washington, DC USA.
C3 Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET);
   National University of Cordoba; Consejo Nacional de Investigaciones
   Cientificas y Tecnicas (CONICET); National University of Rosario
RP Eynard, AR (corresponding author), Univ Nacl Cordoba, Biol Celular Histol & Embriol, Fac Ciencias Med, INICSA,CONICET, RA-5000 Cordoba, Argentina.; Eynard, AR (corresponding author), Consejo Nacl Invest Cient & Tecn, Cordoba, Argentina.
EM aeynard@gmail.com
RI Das, Undurti/A-7918-2009
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NR 58
TC 217
Z9 237
U1 4
U2 332
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0899-9007
EI 1873-1244
J9 NUTRITION
JI Nutrition
PD FEB
PY 2016
VL 32
IS 2
BP 174
EP 178
DI 10.1016/j.nut.2015.08.017
PG 5
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA DC8KM
UT WOS:000369468400003
PM 26706021
OA Green Published
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Rew, KT
   Heidelbaugh, JJ
AF Rew, Karl T.
   Heidelbaugh, Joel J.
TI Erectile Dysfunction
SO AMERICAN FAMILY PHYSICIAN
LA English
DT Article
ID CORONARY-ARTERY-DISEASE; OF-THE-LITERATURE; CARDIOVASCULAR-DISEASE;
   SEXUAL DYSFUNCTION; METABOLIC SYNDROME; RISK-FACTORS; OBESE MEN;
   HYPOGONADOTROPIC HYPOGONADISM; ENDOTHELIAL DYSFUNCTION;
   PSYCHOTROPIC-DRUGS
AB Erectile dysfunction (ED) is the inability to achieve or maintain an erection sufficient for satisfactory sexual performance. It is common, affecting at least 12 million U.S. men. The five-question International Index of Erectile Function allows rapid clinical assessment of ED. The condition can be caused by vascular, neurologic, psychological, and hormonal factors. Common conditions related to ED include diabetes mellitus, hypertension, hyperlipidemia, obesity, testosterone deficiency, and prostate cancer treatment. Performance anxiety and relationship issues are common psychological causes. Medications and substance use can cause or exacerbate ED; antidepressants and tobacco use are the most common. ED is associated with an increased risk of cardiovascular disease, particularly in men with metabolic syndrome. Tobacco cessation, regular exercise, weight loss, and improved control of diabetes, hypertension, and hyperlipidemia are recommended initial lifestyle interventions. Oral phosphodiesterase-5 inhibitors are the first line treatments for ED. Second-line treatments include alprostadil and vacuum devices. Surgically implanted penile prostheses are an option when other treatments have been ineffective. Counseling is recommended for men with psychogenic ED. (Copyright (C) 2016 American Academy of Family Physicians.)
C1 [Rew, Karl T.; Heidelbaugh, Joel J.] Univ Michigan, Sch Med, Dept Family Med, 24 Frank Lloyd Wright Dr, Ann Arbor, MI 48105 USA.
   [Rew, Karl T.; Heidelbaugh, Joel J.] Univ Michigan, Sch Med, Dept Urol, 24 Frank Lloyd Wright Dr, Ann Arbor, MI 48105 USA.
C3 University of Michigan System; University of Michigan; University of
   Michigan System; University of Michigan
RP Rew, KT (corresponding author), Univ Michigan, Sch Med, 24 Frank Lloyd Wright Dr, Ann Arbor, MI 48105 USA.
EM karlr@med.umich.edu
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NR 71
TC 84
Z9 91
U1 0
U2 15
PU AMER ACAD FAMILY PHYSICIANS
PI KANSAS CITY
PA 8880 WARD PARKWAY, KANSAS CITY, MO 64114-2797 USA
SN 0002-838X
EI 1532-0650
J9 AM FAM PHYSICIAN
JI Am. Fam. Physician
PD NOV 15
PY 2016
VL 94
IS 10
BP 820
EP 827
PG 8
WC Primary Health Care; Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA ED2EA
UT WOS:000388655200004
PM 27929275
DA 2025-06-11
ER

PT J
AU Solomon, MB
   Jankord, R
   Flak, JN
   Herman, JP
AF Solomon, Matia B.
   Jankord, Ryan
   Flak, Jonathan N.
   Herman, James P.
TI Chronic stress, energy balance and adiposity in female rats
SO PHYSIOLOGY & BEHAVIOR
LA English
DT Article
DE Obesity; Leptin; Insulin; Corticosterone; Metabolic syndrome; Diabetes
ID HIGH-FAT-DIET; SYRIAN-HAMSTERS; SOCIAL DEFEAT; BODY-WEIGHT; FOOD-INTAKE;
   ACCESS; MASS
AB Stress preferentially increases the consumption of high fat foods in women, suggesting the interaction of these two factors may disproportionately predispose women toward excess weight gain. In the present study, female rats were exposed to a chronic high fat or chow diet and were exposed to 4 weeks of chronic variable stress (CVS) or served as home cage controls. Control females exposed to a high fat diet displayed many symptoms of the metabolic syndrome including increased body weight gain, total and visceral adiposity and insulin and leptin concentrations relative to all groups. However, CVS-high fat, CVS chow and control chow groups had similar body weight gain and caloric efficiency. This finding suggests that CVS increases energy expenditure much more in females exposed to a high fat diet relative to those fed a standard chow diet. The CVS-high fat group had increased adiposity and increased circulating leptin and insulin concentrations, despite the fact that their body weight did not differ from the controls. These results underscore the importance of assessing the degree of adiposity, rather than body weight alone, as an index of overall metabolic health. Overall, the data indicate that in female rats, chronic stress prevents high fat diet related increases in body weight, but does not prevent high fat diet induced increases in adiposity when compared to chow-fed females. (C) 2010 Elsevier Inc. All rights reserved.
C1 [Solomon, Matia B.; Jankord, Ryan; Flak, Jonathan N.; Herman, James P.] Univ Cincinnati, Coll Med, Dept Psychiat, Cincinnati, OH 45267 USA.
   [Flak, Jonathan N.; Herman, James P.] Univ Cincinnati, Coll Med, Neurosci Program, Cincinnati, OH 45267 USA.
C3 University System of Ohio; University of Cincinnati; University System
   of Ohio; University of Cincinnati
RP Solomon, MB (corresponding author), Univ Cincinnati, Metab Dis Inst, 2170 E Galbraith Rd,Bldg E,Room 216,ML 0506, Cincinnati, OH 45237 USA.
EM matia.solomon@uc.edu
RI Solomon, Matia/KQV-0178-2024; Herman, James/D-4960-2015
OI Herman, James/0000-0003-3571-2406
FU NIH [MH 069725]
FX The authors would like to thank Nathan Evanson, Ph.D., Rong Zhang,
   Ph.D., Yvonne Ulrich-Lai, Ph.D., Anne Christiansen, Kenneth Jones and
   Benjamin Packard for help with tissue collection and help with
   radioimmunoassay. We also thank Michelle Foster, Ph.D. and Stephen Woods
   Ph.D. for thoughtful discussions concerning the manuscript. Finally, we
   would like to thank Diego Perez-tilve for help with the insulin and
   leptin analyses. This work was supported in part by NIH MH 069725 to JPH
   and an ARRA supplement to MBS.
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NR 23
TC 29
Z9 33
U1 2
U2 17
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0031-9384
J9 PHYSIOL BEHAV
JI Physiol. Behav.
PD JAN 10
PY 2011
VL 102
IS 1
BP 84
EP 90
DI 10.1016/j.physbeh.2010.09.024
PG 7
WC Psychology, Biological; Behavioral Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Behavioral Sciences
GA 707LL
UT WOS:000286288000013
PM 20932852
OA Green Accepted
DA 2025-06-11
ER

PT J
AU de Morentin, PBM
   Varela, L
   Ferno, J
   Nogueiras, R
   Diéguez, C
   López, M
AF Martinez de Morentin, Pablo B.
   Varela, Luis
   Ferno, Johan
   Nogueiras, Ruben
   Dieguez, Carlos
   Lopez, Miguel
TI Hypothalamic lipotoxicity and the metabolic syndrome
SO BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
LA English
DT Review
DE Endoplasmic reticulum (ER) stress; Fatty acids; Hypothalamus; Lipid
   metabolism; Lipid sensing; Lipotoxicity
ID ENDOPLASMIC-RETICULUM STRESS; ACTIVATED PROTEIN-KINASE; ACID SYNTHASE
   INHIBITOR; FREE FATTY-ACIDS; BETA-CELL DYSFUNCTION; FOOD-INTAKE;
   MALONYL-COA; ADIPOSE-TISSUE; ER STRESS; MAMMALIAN TARGET
AB Ectopic accumulation of lipids in peripheral tissues, such as pancreatic 0 cells, liver, heart and skeletal muscle, leads to lipotoxicity, a process that contributes substantially to the pathophysiology of insulin resistance, type 2 diabetes, steatotic liver disease and heart failure. Current evidence has demonstrated that hypothalamic sensing of circulating lipids and modulation of hypothalamic endogenous fatty acid and lipid metabolism are two bona fide mechanisms modulating energy homeostasis at the whole body level. Key enzymes, such as AMP-activated protein kinase (AMPK) and fatty acid synthase (FAS), as well as intermediate metabolites, such as malonyl-CoA and long-chain fatty acids-CoA (LCFAs-CoA), play a major role in this neuronal network, integrating peripheral signals with classical neuropeptide-based mechanisms. However, one key question to be addressed is whether impairment of lipid metabolism and accumulation of specific lipid species in the hypothalamus, leading to lipotoxicity, have deleterious effects on hypothalamic neurons. In this review, we summarize what is known about hypothalamic lipid metabolism with focus on the events associated to lipotoxicity, such as endoplasmic reticulum (ER) stress in the hypothalamus. A better understanding of these molecular mechanisms will help to identify new drug targets for the treatment of obesity and metabolic syndrome. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Martinez de Morentin, Pablo B.; Varela, Luis; Ferno, Johan; Nogueiras, Ruben; Dieguez, Carlos; Lopez, Miguel] Univ Santiago de Compostela, Inst Invest Sanitaria, Dept Physiol, Sch Med, Santiago De Compostela 15782, A Coruna, Spain.
C3 Universidade de Santiago de Compostela
RP López, M (corresponding author), Univ Santiago de Compostela, Inst Invest Sanitaria, Dept Physiol, Sch Med, S Francisco S-N, Santiago De Compostela 15782, A Coruna, Spain.
EM m.lopez@usc.es
RI Nogueiras, Ruben/AAS-9427-2021; Varela, Luis/ABG-7581-2020; Fernø,
   Johan/D-5024-2011; Lopez, Miguel/ABF-4844-2021; Blanco Martinez de
   Morentin, Pablo/K-5403-2014
OI Nogueiras, Ruben/0000-0002-9976-9930; Lopez, Miguel/0000-0002-7823-1648;
   Blanco Martinez de Morentin, Pablo/0000-0002-0684-3215; Varela,
   Luis/0000-0001-7794-7241; dieguez, carlos/0000-0002-0919-4337
FU Xunta de Galicia [PGIDIT06PXIB208063PR, GRC2006/66]; Fondo
   Investigationes Sanitarias [PI061700]; Ministerio de Educacion y Ciencia
   [BFU2005, RyC-2007-00211]; European Union [Health-F2-2008-223713]
FX This work has been supported by grants from Xunta de Galicia (C.D.:
   PGIDIT06PXIB208063PR and ML: GRC2006/66), Fondo Investigationes
   Sanitarias (M.L.: PI061700), Ministerio de Educacion y Ciencia (C.D.:
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NR 153
TC 55
Z9 56
U1 1
U2 14
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1388-1981
EI 1879-2618
J9 BBA-MOL CELL BIOL L
JI Biochim. Biophys. Acta Mol. Cell Biol. Lipids
PD MAR
PY 2010
VL 1801
IS 3
SI SI
BP 350
EP 361
DI 10.1016/j.bbalip.2009.09.016
PG 12
WC Biochemistry & Molecular Biology; Biophysics; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Cell Biology
GA 568YT
UT WOS:000275563300019
PM 19796707
DA 2025-06-11
ER

PT J
AU Porter, ML
   Kimball, AB
AF Porter, Martina L.
   Kimball, Alexa B.
TI Comorbidities of hidradenitis suppurativa
SO SEMINARS IN CUTANEOUS MEDICINE AND SURGERY
LA English
DT Article
ID INFLAMMATORY-BOWEL-DISEASE; PYODERMA-GANGRENOSUM; AUTOINFLAMMATORY
   SYNDROME; ACNE CONGLOBATA; SPONDYLOARTHRITIS; COMPLICATIONS; PREVALENCE;
   THERAPY; SMOKING; COHORT
AB Hidradenitis suppurativa (HS) is an inflammatory skin disorder with many associated comorbidities, including obesity, metabolic syndrome, smoking, depression, arthritis, autoinflammatory syndromes, inflammatory bowel disease, and genetic syndromes. In addition, HS patients can suffer from a variety of diseases related to the chronic inflammatory nature of their HS such as cardiovascular disease and anemia. An understanding of these comorbidities and associations is essential for the management of HS, and routine screening for these entities should be considered in all HS patients. (C) 2017 Frontline Medical Communications
C1 [Porter, Martina L.] Massachusetts Gen Hosp, Dept Dermatol, Clin Unit Res Trials & Outcomes Skin CURTIS, Boston, MA 02114 USA.
   [Kimball, Alexa B.] Harvard Med Sch, Dept Dermatol, Boston, MA 02115 USA.
   [Kimball, Alexa B.] Beth Israel Deaconess Med Ctr, Harvard Med Fac Phys, Boston, MA 02215 USA.
C3 Harvard University; Harvard University Medical Affiliates; Massachusetts
   General Hospital; Harvard University; Harvard Medical School; Harvard
   University; Harvard University Medical Affiliates; Beth Israel Deaconess
   Medical Center; Harvard Medical School
RP Kimball, AB (corresponding author), Harvard Med Sch, Dept Dermatol, Boston, MA 02115 USA.; Kimball, AB (corresponding author), Beth Israel Deaconess Med Ctr, Harvard Med Fac Phys, Boston, MA 02215 USA.
EM harvardskinstudies@gmail.com
RI Kimball, Alexandra/M-6347-2019
OI Kimball, Alexandra/0000-0001-9405-0479; Porter,
   Martina/0000-0002-4738-4385
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NR 30
TC 22
Z9 22
U1 0
U2 6
PU FRONTLINE MEDICAL COMMUNICATIONS
PI THE WOODLANDS
PA WRIGHTS MEDIA, 2407 TIMBERLOCH PLACE, SUITE B, THE WOODLANDS, TX 77386
   USA
SN 1085-5629
EI 1558-0768
J9 SEMIN CUTAN MED SURG
JI Semin. Cutan. Med. Surg.
PD JUN
PY 2017
VL 36
IS 2
BP 55
EP 57
DI 10.12788/j.sder.2017.018
PG 3
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA EX6XY
UT WOS:000403386600004
PM 28538744
DA 2025-06-11
ER

PT J
AU Perry, BI
   Khandaker, GM
   Marwaha, S
   Thompson, A
   Zammit, S
   Singh, SP
   Upthegrove, R
AF Perry, B. I.
   Khandaker, G. M.
   Marwaha, S.
   Thompson, A.
   Zammit, S.
   Singh, S. P.
   Upthegrove, R.
TI Insulin resistance and obesity, and their association with depression in
   relatively young people: findings from a large UK birth cohort
SO PSYCHOLOGICAL MEDICINE
LA English
DT Article
DE ALSPAC; depression; inflammation; insulin resistance; obesity;
   overweight
ID METABOLIC SYNDROME; DIABETES PREVALENCE; PHYSICAL-ACTIVITY; BIPOLAR
   DISORDER; MAJOR DEPRESSION; SEX-DIFFERENCES; RISK; ADULTS; DYSLIPIDEMIA;
   INFLAMMATION
AB BackgroundDepression frequently co-occurs with disorders of glucose and insulin homeostasis (DGIH) and obesity. Low-grade systemic inflammation and lifestyle factors in childhood may predispose to DGIH, obesity and depression. We aim to investigate the cross-sectional and longitudinal associations among DGIH, obesity and depression, and to examine the effect of demographics, lifestyle factors and antecedent low-grade inflammation on such associations in young people.MethodsUsing the Avon Longitudinal Study of Parents and Children birth cohort, we used regression analyses to examine: (1) cross-sectional and (2) longitudinal associations between measures of DGIH [insulin resistance (IR); impaired glucose tolerance] and body mass index (BMI) at ages 9 and 18 years, and depression (depressive symptoms and depressive episode) at age 18 years and (3) whether sociodemographics, lifestyle factors or inflammation [interleukin-6 (IL-6) at age 9 years] confounded any such associations.ResultsWe included 3208 participants. At age 18 years, IR and BMI were positively associated with depression. These associations may be explained by sociodemographic and lifestyle factors. There were no longitudinal associations between DGIH/BMI and depression, and adjustment for IL-6 and C-reactive protein did not attenuate associations between IR/BMI and depression; however, the longitudinal analyses may have been underpowered.ConclusionsYoung people with depression show evidence of DGIH and raised BMI, which may be related to sociodemographic and lifestyle effects such as deprivation, smoking, ethnicity and gender. In future, studies with larger samples are required to confirm this. Preventative strategies for the poorer physical health outcomes associated with depression should focus on malleable lifestyle factors.
C1 [Perry, B. I.; Khandaker, G. M.] Univ Cambridge, Dept Psychiat, Cambridge, England.
   [Perry, B. I.; Khandaker, G. M.] Cambridgeshire & Peterborough Natl Hlth Serv Fdn, Cambridge, England.
   [Khandaker, G. M.] Natl Inst Hlth Res Cambridge Biomed Res Ctr, Cambridge, England.
   [Marwaha, S.; Upthegrove, R.] Univ Birmingham, Inst Mental Hlth, Birmingham, W Midlands, England.
   [Marwaha, S.] Birmingham & Solihull Mental Hlth Fdn NHS Trust, Birmingham, W Midlands, England.
   [Thompson, A.; Singh, S. P.] Coventry & Warwickshire Partnership NHS Trust, Coventry, W Midlands, England.
   [Thompson, A.; Singh, S. P.] Univ Warwick, Unit Mental Hlth & Wellbeing, Coventry, W Midlands, England.
   [Zammit, S.] Univ Bristol, Sch Social & Community Med, Ctr Acad Mental Hlth, Bristol, Avon, England.
   [Zammit, S.] Cardiff Univ, Inst Psychol Med & Clin Neurosci, Med Res Council Ctr Neuropsychiat Genet & Genom, Cardiff, Wales.
   [Upthegrove, R.] Birmingham Womens & Childrens NHS Trust, Early Intervent Serv, Birmingham, W Midlands, England.
C3 University of Cambridge; University of Birmingham; University of
   Warwick; University of Bristol; Cardiff University
RP Perry, BI (corresponding author), Univ Cambridge, Dept Psychiat, Cambridge, England.; Perry, BI (corresponding author), Cambridgeshire & Peterborough Natl Hlth Serv Fdn, Cambridge, England.
EM bip20@medschl.cam.ac.uk
RI Khandaker, Gulam/G-6171-2019; thompson, andrew/AAQ-8744-2020;
   Upthegrove, Rachel/AAD-9761-2022; Thompson, Andrew/F-3153-2012; Marwaha,
   Steven/G-4489-2013
OI Thompson, Andrew/0000-0002-0567-6013; Perry, Benjamin
   I./0000-0002-1533-026X; Khandaker, Golam/0000-0002-4935-9220; Marwaha,
   Steven/0000-0002-0303-9942; Upthegrove, Rachel/0000-0001-8204-5103
FU UK Medical Research Council [102215/2/13/2]; Wellcome Trust
   [102215/2/13/2, 08426812/Z/07/Z]; Coventry and Warwickshire Partnership
   NHS Trust Research Development Fund; National Institute for Health
   Research (NIHR Doctoral Research Fellowship) [DRF-2018-11-ST2-018];
   Wellcome Trust (Intermediate Clinical Fellowship) [201486/Z/16/Z]; MRC
   (MICA: Mental Health Data Pathfinder) [MC_PC_17213]; MQ: Transforming
   Mental Health (Data Science Award) [MQDS17/40]; MRC [MC_PC_17213,
   MC_PC_19009] Funding Source: UKRI; National Institutes of Health
   Research (NIHR) [DRF-2018-11-ST2-018] Funding Source: National
   Institutes of Health Research (NIHR)
FX The UK Medical Research Council and Wellcome Trust (Grant no.
   102215/2/13/2) and the University of Bristol provide core support for
   ALSPAC. This publication is the work of the authors, who will serve as
   guarantors for the contents of this paper. Funding for data access was
   obtained from Coventry and Warwickshire Partnership NHS Trust Research
   Development Fund. This report is independent research supported by the
   National Institute for Health Research (NIHR Doctoral Research
   Fellowship, Dr Benjamin Ian Perry, DRF-2018-11-ST2-018). The views
   expressed in this publication are those of the author(s) and not
   necessarily those of the NHS, the National Institute for Health Research
   or the Department of Health and Social Care. Dr Khandaker acknowledges
   funding support from the Wellcome Trust (Intermediate Clinical
   Fellowship; grant no. 201486/Z/16/Z), MRC (MICA: Mental Health Data
   Pathfinder; grant no. MC_PC_17213) and MQ: Transforming Mental Health
   (Data Science Award; grant no. MQDS17/40). A comprehensive list of
   grants funding is available on the ALSPAC website
   (http://www.bristol.ac.uk/alspac/external/documents/grantacknowledgement
   s.pdf/); this research was specifically funded by The Wellcome Trust
   (Grant no. 08426812/Z/07/Z).
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NR 67
TC 25
Z9 28
U1 1
U2 17
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
SN 0033-2917
EI 1469-8978
J9 PSYCHOL MED
JI Psychol. Med.
PD MAR
PY 2020
VL 50
IS 4
BP 556
EP 565
DI 10.1017/S0033291719000308
PG 10
WC Psychology, Clinical; Psychiatry; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA LI4CW
UT WOS:000529434200003
PM 30854996
OA Green Submitted, Green Published, Green Accepted, hybrid
DA 2025-06-11
ER

PT J
AU Ferreira, DMS
   Simao, AL
   Rodrigues, CMP
   Castro, RE
AF Ferreira, Duarte M. S.
   Simao, Andre L.
   Rodrigues, Cecilia M. P.
   Castro, Rui E.
TI Revisiting the metabolic syndrome and paving the way for microRNAs in
   non-alcoholic fatty liver disease
SO FEBS JOURNAL
LA English
DT Review
DE apoptosis biomarkers; ER stress; gut microbiota; insulin resistance;
   metabolism; miRNAs; NAFLD; oxidative stress
ID ENDOPLASMIC-RETICULUM STRESS; TYROSINE-PHOSPHATASE 1B;
   NECROSIS-FACTOR-ALPHA; DIET-INDUCED OBESITY; NF-KAPPA-B;
   INSULIN-RESISTANCE; HEPATIC STEATOSIS; GUT MICROBIOTA;
   GENERAL-POPULATION; DOWN-REGULATION
AB Non-alcoholic fatty liver disease (NAFLD) comprises a spectrum of stages from simple steatosis to non-alcoholic steatohepatitis, which can progress to fibrosis, cirrhosis and, ultimately, hepatocellular carcinoma. Despite being one of the most common chronic liver diseases, NAFLD pathogenesis remains largely unknown. In this review, we discuss the key molecular mechanisms involved in NAFLD development and progression, focusing on the emerging role of microRNAs. NAFLD is intrinsically related to obesity and the metabolic syndrome. Changes in lipid metabolism increase free fatty acids in blood, which in turn induces peripheral insulin resistance and increases oxidative and endoplasmic reticulum stress. Although not yet considered in the diagnosis of NAFLD, recent reports also reinforce the crucial role of apoptosis in disease progression via activation of either death receptor or mitochondrial pathways and p53. In addition, the role of gut microbiota and the gut-liver axis has been recently associated with NAFLD. Finally, there is an accumulating and growing body of evidence supporting the role of microRNAs in NAFLD pathogenesis and progression, as well as hinting at their use as biomarkers or therapeutic tools. The ultimate goal is to review different molecular pathways that may underlie NAFLD pathogenesis in the hope of finding targets for new and efficient therapeutic interventions.
C1 [Ferreira, Duarte M. S.; Simao, Andre L.; Rodrigues, Cecilia M. P.; Castro, Rui E.] Univ Lisbon, Fac Farm, Inst Invest Medicamento iMed ULisboa, P-1649003 Lisbon, Portugal.
   [Rodrigues, Cecilia M. P.; Castro, Rui E.] Univ Lisbon, Fac Farm, Dept Biochem & Human Biol, P-1649003 Lisbon, Portugal.
C3 Universidade de Lisboa; Universidade de Lisboa
RP Castro, RE (corresponding author), Univ Lisbon, Fac Farm, Inst Invest Medicamento iMed ULisboa, Av Prof Gama Pinto, P-1649003 Lisbon, Portugal.
EM ruieduardocastro@ff.ul.pt
RI Castro, Rui/AAG-4179-2021; Castro, Rui/I-2975-2013; Sacramento Ferreira,
   Duarte Miguel/E-4270-2012; Simao, Andre/M-9767-2018; Pereira Rodrigues,
   Cecilia Maria/M-3572-2013
OI Castro, Rui/0000-0002-7417-0091; Sacramento Ferreira, Duarte
   Miguel/0000-0001-5940-7102; Simao, Andre/0000-0002-5986-1089; Pereira
   Rodrigues, Cecilia Maria/0000-0002-4829-754X
FU Fundacao para a Ciencia e a Tecnologia [PTDC/SAU-ORG/111930/2009,
   PTDC/BIM-MEC/0873/2012]; FCT, Lisbon, Portugal [SFRH/BD/60521/2009];
   Fundação para a Ciência e a Tecnologia [PTDC/BIM-MEC/0873/2012,
   PTDC/SAU-ORG/111930/2009, SFRH/BD/60521/2009] Funding Source: FCT
FX Supported by grants from Fundacao para a Ciencia e a Tecnologia
   PTDC/SAU-ORG/111930/2009 and PTDC/BIM-MEC/0873/2012. D. M. S. F. was
   awarded fellowship SFRH/BD/60521/2009 from FCT, Lisbon, Portugal. The
   authors apologize to those authors whose work they have not been able to
   cite as a result of limited space. The authors also thank all members of
   the laboratory for insightful discussions.
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NR 170
TC 55
Z9 58
U1 0
U2 24
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-464X
EI 1742-4658
J9 FEBS J
JI FEBS J.
PD JUN
PY 2014
VL 281
IS 11
BP 2503
EP 2524
DI 10.1111/febs.12806
PG 22
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA AJ4VJ
UT WOS:000337676100002
PM 24702768
OA Bronze
DA 2025-06-11
ER

PT J
AU Kaiser, A
   Schaefer, SM
   Behrendt, I
   Eichner, G
   Fasshauer, M
AF Kaiser, Anna
   Schaefer, Sylva M.
   Behrendt, Inken
   Eichner, Gerrit
   Fasshauer, Mathias
TI Association of sugar intake from different sources with incident
   depression in the prospective cohort of UK Biobank participants
SO EUROPEAN JOURNAL OF NUTRITION
LA English
DT Article
DE Carbohydrates; Depression; Metabolic syndrome; Sugar; UK Biobank
ID LOW-CARBOHYDRATE; NEUROTROPHIC FACTOR; WEIGHT-LOSS; RISK; DIET;
   CONSUMPTION; FAT; LIQUID; INDEX; FOODS
AB Purpose To elucidate the association of different sources of free sugars (FS) and intrinsic sugars with depression risk in the prospective population-based UK Biobank cohort. Methods Sugar consumption was assessed in 188,426 participants (age range: 39-72 years, 54.4% female) with at least one web-based dietary questionnaire (Oxford WebQ). The hazard ratios (HR) for incident depression were assessed with Cox proportional hazard regression models including sugar intake from different sources as penalized cubic splines to allow non-linear predictor effects. Over a mean follow-up of 12.3 (standard deviation 1.8) years, 5410 incident depression cases occurred. Results FS intake was significantly associated with depression risk in an ascending approximately linear way with the lowest HR observed at 9% total energy (%E). In contrast, consumption of intrinsic sugars was not significantly related with incident depression. FS in beverages were significantly associated with depression risk in an ascending approximately linear way with the lowest HR at 4%E whereas no association was found for FS in solids. Concerning beverage types, FS in soda/fruit drinks, milk-based drinks, and tea/coffee were significantly and positively related to depression risk whereas the association was U-shaped for juice. Major findings were robust in sensitivity analyses. Conclusion Only some sources of FS are positively associated with incident depression. Public health initiatives targeting FS subtypes might be most effective concerning depression risk if focused on the reduction of sugary beverages and more specifically soda/fruit drinks, milk-based drinks, and tea/coffee.
C1 [Kaiser, Anna; Schaefer, Sylva M.; Behrendt, Inken; Fasshauer, Mathias] Justus Liebig Univ Giessen, Inst Nutr Sci, D-35390 Giessen, Germany.
   [Eichner, Gerrit] Justus Liebig Univ Giessen, Math Inst, Giessen, Germany.
   [Fasshauer, Mathias] Univ Leipzig, Dept Internal Med Endocrinol Nephrol & Rheumatol, Leipzig, Germany.
C3 Justus Liebig University Giessen; Justus Liebig University Giessen;
   Leipzig University
RP Kaiser, A (corresponding author), Justus Liebig Univ Giessen, Inst Nutr Sci, D-35390 Giessen, Germany.
EM anna.kaiser@ernaehrung.uni-giessen.de
RI Schaefer, Sylva Mareike/KWT-4078-2024
OI Kaiser, Anna/0000-0003-1705-6994; Schaefer, Sylva
   Mareike/0000-0001-5949-3282
FU Deutsche Forschungsgemeinschaft (DFG) [SFB 1052/2 C6]; Deutsche Diabetes
   Stiftung; Projekt DEAL
FX Open Access funding enabled and organized by Projekt DEAL. This work was
   supported by the Deutsche Forschungsgemeinschaft (DFG) (SFB 1052/2 C6)
   and the Deutsche Diabetes Stiftung to MF. The funders had no role in the
   design, analysis, or writing of this article, and the decision to
   submit.
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NR 51
TC 6
Z9 6
U1 1
U2 15
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1436-6207
EI 1436-6215
J9 EUR J NUTR
JI Eur. J. Nutr.
PD MAR
PY 2023
VL 62
IS 2
BP 727
EP 738
DI 10.1007/s00394-022-03022-7
EA OCT 2022
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 9E6LN
UT WOS:000864960200001
PM 36205767
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Wu, YT
   Wu, SB
   Wei, YH
AF Wu, Y. -T.
   Wu, S. -B.
   Wei, Y. -H.
TI Roles of sirtuins in the regulation of antioxidant defense and
   bioenergetic function of mitochondria under oxidative stress
SO FREE RADICAL RESEARCH
LA English
DT Review
DE mitochondria; reactive oxygen species; Aging; metabolic syndrome;
   oxidative stress; insulin
ID FATTY-ACID OXIDATION; CARDIAC GLUCOSE-OXIDATION; MEDIATED CELL-DEATH;
   4977 BP DELETION; CALORIE RESTRICTION; SIRT3 DEACETYLATES;
   SKELETAL-MUSCLE; METABOLIC SYNDROME; MALONYL-COA; SIRT3-MEDIATED
   DEACETYLATION
AB In addition to serving as the power house of mammalian cells, mitochondria are crucial for the maintenance of cellular homeostasis in response to physiological or environmental changes. Several lines of evidence suggest that posttranslational modifi cation (PTM) of proteins plays a pivotal role in the regulation of the bioenergetic function of mitochondria. Among them, reversible lysine acetylation of mitochondrial proteins has been established as one of the key mechanisms in cellular response to energy demand by modulating the flux of a number of key metabolic pathways. In this article, we focus on the role of Sirt3-mediated deacetylation in: (1) flexibility of energy metabolism, (2) activation of antioxidant defense, and (3) maintenance of cellular redox status in response to dietary challenge and oxidative stress. We suggest that oxidative stress-elicited down-regulation of Sirt3 plays a role in the pathophysiology of diabetes, cardiac hypotrophy, mitochondrial diseases, and age-related diseases. Besides, the physiological role of newly identified lysine acylation mediated by Sirt5 and its biochemical effects on oxidative metabolism are also discussed. Moreover, we have integrated the regulatory function of several protein kinases that are involved in the phosphorylation of mitochondrial enzymes during oxidative stress. Finally, the functional consequence of the synergistic regulation through diverse protein modifi cations is emphasized on the maintenance of the bioenergetic homeostasis and metabolic adaptation of the animal and human cells. Together, we have provided an updated review of PTM in mitochondrial biology and their implications in aging and human diseases through an intricate regulation of energy metabolism under oxidative stress.
C1 [Wu, Y. -T.; Wu, S. -B.; Wei, Y. -H.] Mackay Med Coll, Dept Med, New Taipei City 252, Taiwan.
   [Wei, Y. -H.] Natl Yang Ming Univ, Sch Life Sci, Dept Biochem & Mol Biol, Taipei 112, Taiwan.
C3 Mackay Medical College; National Yang Ming Chiao Tung University
RP Wei, YH (corresponding author), Mackay Med Coll, Dept Med, New Taipei City 252, Taiwan.
EM joeman@mmc.edu.tw
RI Wei, Yau-Huei/ABA-6841-2021; TMU, barry0110/AAV-4030-2021
OI Wei, Yau-Huei/0000-0002-6429-2546
FU Mackay Medical College [982A01]
FX The authors would like to acknowledge the support of an intramural
   research grant 982A01 from Mackay Medical College.
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NR 127
TC 40
Z9 46
U1 0
U2 36
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1071-5762
EI 1029-2470
J9 FREE RADICAL RES
JI Free Radic. Res.
PD SEP
PY 2014
VL 48
IS 9
BP 1070
EP 1084
DI 10.3109/10715762.2014.920956
PG 15
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA AN3AA
UT WOS:000340456000010
PM 24797412
DA 2025-06-11
ER

PT J
AU Flahault, A
   Paquette, K
   Fernandes, RO
   Delfrate, J
   Cloutier, A
   Henderson, M
   Lavoie, JC
   Mâsse, B
   Nuyt, AM
   Luu, TM
AF Flahault, Adrien
   Paquette, Katryn
   Fernandes, Rafael Oliveira
   Delfrate, Jacques
   Cloutier, Anik
   Henderson, Melanie
   Lavoie, Jean-Claude
   Masse, Benoit
   Nuyt, Anne Monique
   Luu, Thuy Mai
CA HAPI Collaborating Grp
TI Increased Incidence but Lack of Association Between Cardiovascular Risk
   Factors in Adults Born Preterm
SO HYPERTENSION
LA English
DT Article
DE adiposity; diabetes mellitus; inflammation; metabolic syndrome;
   oxidative stress
ID C-REACTIVE PROTEIN; OXIDATIVE STRESS; BLOOD-PRESSURE; YOUNG-ADULTS;
   METABOLIC SYNDROME; BIRTH-WEIGHT; OXYGEN; MARKERS; HEALTH; INFLAMMATION
AB Preterm birth incurs an increased risk of early cardiovascular events and death. In the general population, cardiovascular risk factors cluster in the context of inflammation and oxidative stress. Whether this also occurs in young adults born preterm is unknown. We analyzed 101 healthy young adults (ages 18-29) born preterm (<= 29 weeks of gestation) and 105 full-term controls, predominantly (90%) white. They underwent a comprehensive clinical and biological evaluation, including measurement of blood pressure, lung function (spirometry), glucose metabolism (fasting glucose, glycated hemoglobin, and oral glucose tolerance test), as well as biomarkers of inflammation and oxidative stress. Individuals born preterm were at higher risk than those born full-term of stage >= 1 hypertension (adjusted odds ratio, 2.91 [95% CI, 1.51-5.75]), glucose intolerance (adjusted odds ratio, 2.22 [95% CI, 1.13-4.48]), and airflow limitation (adjusted odds ratio, 3.47 [95% CI, 1.76-7.12]). Hypertension was strongly associated with adiposity and with glucose intolerance in participants born full-term but not in those born preterm. We did not find any group difference in levels of biomarkers of inflammation and oxidative stress. In individuals born preterm, inflammation, and oxidative stress were not related to hypertension or glucose intolerance but were associated with adiposity. In those born preterm, cardiovascular risk factors were not related to each other suggesting different pathophysiological pathways leading to the development of cardiovascular risk following preterm birth. Clinicians should consider screening for these abnormalities irrespectively of other risk factors in this at-risk population.
C1 [Flahault, Adrien; Paquette, Katryn; Fernandes, Rafael Oliveira; Delfrate, Jacques; Cloutier, Anik; Henderson, Melanie; Nuyt, Anne Monique; Luu, Thuy Mai] Univ Montreal, St Justine Univ Hosp & Res Ctr, Dept Pediat, Montreal, PQ, Canada.
   [Lavoie, Jean-Claude] Univ Montreal, St Justine Univ Hosp & Res Ctr, Dept Nutr, Montreal, PQ, Canada.
   [Masse, Benoit] Univ Montreal, St Justine Univ Hosp & Res Ctr, Dept Social & Prevent Med, Montreal, PQ, Canada.
C3 Universite de Montreal; Universite de Montreal; Universite de Montreal
RP Nuyt, AM; Luu, TM (corresponding author), St Justine Univ Hosp & Res Ctr, Dept Pediat, 3175 Chemin Cote St Catherine, Montreal, PQ H3T 1C5, Canada.
EM anne.monique.nuyt@umontreal.ca; thuy.mai.luu@umontreal.ca
RI Lavoie, Jean-claude/K-2701-2016; Luu, Thuy Mai/HKE-8217-2023; Flahault,
   Adrien/KAM-1829-2024; Flahault, Adrien/Q-4576-2017; Oliveira Fernandes,
   Rafael/V-7782-2018
OI Flahault, Adrien/0000-0003-4632-6332; Bertagnolli,
   Mariane/0000-0002-1093-1445; Oliveira Fernandes,
   Rafael/0000-0003-0853-726X
FU Canadian Institutes of Health Research [CIHR 133572]; Canada Foundation
   for Innovation; Fondation CHU Sainte-Justine; Fonds de recherche du
   Quebec -Sante (FRQS); FRQS/Fondation des Etoiles fellowship award
FX This work was supported by the Canadian Institutes of Health Research
   (CIHR 133572 to A.M. Nuyt and T.M. Luu), the Canada Foundation for
   Innovation (to A.M. Nuyt) and the Fondation CHU Sainte-Justine (to A.M.
   Nuyt), a Fonds de recherche du Quebec -Sante (FRQS) salary award to T.M.
   Luu, a FRQS/Fondation des Etoiles fellowship award to A. Flahault.
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NR 45
TC 43
Z9 44
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0194-911X
EI 1524-4563
J9 HYPERTENSION
JI Hypertension
PD MAR
PY 2020
VL 75
IS 3
BP 796
EP 805
DI 10.1161/HYPERTENSIONAHA.119.14335
PG 10
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA LH5NP
UT WOS:000528832000029
PM 31983307
OA Bronze
DA 2025-06-11
ER

PT J
AU Altuna, ME
   Mazzetti, MB
   Rago, LF
   de Viale, LCS
   Damasco, MC
AF Altuna, M. E.
   Mazzetti, M. B.
   Rago, L. F.
   San Martin de Viale, L. C.
   Damasco, M. C.
TI Hepatic 11 beta-hydroxysteroid dehydrogenase 1 involvement in
   alterations of glucose metabolism produced by acidotic stress in rat
SO JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
LA English
DT Article
DE HSD1; Stress; Glycyrrhetinic acid; Glucose; PEPCK
ID LIVER-GLYCOGEN PHOSPHORYLASE; INDOLE-SITE INHIBITORS; OBESE ZUCKER RATS;
   11-BETA-HYDROXYSTEROID DEHYDROGENASE; GLUCOCORTICOID ACTION; TYPE-1;
   MODEL; CORTISOL; ISOFORMS; MUSCLE
AB M.E. ALTUNA, M.B. MAZZETTI, L.F. RAGO, L.C. SAN MARTIN DE VIALE and M.C. DAMASCO. Hepatic 11 beta-hydroxysteroid dehydrogenase I involvement in alterations of glucose metabolism produced by acidotic stress in rat. J Physiol Biochem, 65 (4), 329-338, 2009.
   11 beta-hydroxysteroid dehydrogenase (HSDs) enzymes regulate the activity of glucocorticoids in target organs. HSD1, one of the two existing isoforms, locates mainly in CNS, liver and adipose tissue. HSD1 is involved in the pathogenesis of diseases such as obesity, insulin resistance, arterial hypertension and the Metabolic Syndrome. The stress produced by HCl overload triggers metabolic acidosis and increases liver HSD1 activity associated with increased phosphoenolpyruvate carboxykinase, a regulatory enzyme of gluconeogenesis that is activated by glucocorticoids, with increased glycaemia and glycogen breakdown. The aim of this study was to analyze whether the metabolic modifications triggered by HCl stress are due to increased liver HSD1 activity. Glycyrrhetinic acid, a potent HDS inhibitor, was administered subcutaneously (20 mg/ml) to stressed and unstressed four months old male Sprague Dawley rats to investigate changes in liver HSD1, phosphoenolpyruvate carboxykinase (PECPK) and glycogen phosphorylase activities and plasma glucose levels. It was observed that all these parameters increased in stressed animals, but that treatment with glycyrrhetinic acid significantly reduced their levels. In conclusion, our results demonstrate the involvement of HSD1 in stress induced carbohydrate disturbances and could contribute to the impact of HSD1 inhibitors on carbohydrate metabolism and its relevance in the study of Metabolic Syndrome Disorder and non insulin-dependent diabetes mellitus.
C1 [Altuna, M. E.; Rago, L. F.; Damasco, M. C.] Consejo Nacl Invest Cient & Tecn, Lab Fis Endocrina, RA-1033 Buenos Aires, DF, Argentina.
   [Mazzetti, M. B.; San Martin de Viale, L. C.] Univ Buenos Aires, Fac Ciencias Exactas & Nat, Dept Quim Biol, Lab Disturbios Metab Xenobiot Salud Humana & Medi, Buenos Aires, DF, Argentina.
C3 Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET);
   University of Buenos Aires
RP Damasco, MC (corresponding author), Consejo Nacl Invest Cient & Tecn, Lab Fis Endocrina, RA-1033 Buenos Aires, DF, Argentina.
EM dimxsa@qb.fcen.uba.ar
FU CONICET (Consejo Nacional de Investigaciones Cientificas y Tecnicas);
   Universidad de Buenos Aires
FX This work has been supported by grants from the CONICET (Consejo
   Nacional de Investigaciones Cientificas y Tecnicas) and the Universidad
   de Buenos Aires. M.C. Damasco and L.C. San Martin de Via le are
   Scientific Research Career Members of the CONICET.
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NR 35
TC 0
Z9 0
U1 0
U2 1
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1138-7548
EI 1877-8755
J9 J PHYSIOL BIOCHEM
JI J. Physiol. Biochem.
PD DEC
PY 2009
VL 65
IS 4
BP 329
EP 337
DI 10.1007/BF03185927
PG 9
WC Biochemistry & Molecular Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Physiology
GA 580IW
UT WOS:000276442600001
PM 20358345
DA 2025-06-11
ER

PT J
AU Sundkvist, GMG
   Hjemdahl, P
   Kahan, T
   Melcher, A
AF Sundkvist, G. M. G.
   Hjemdahl, P.
   Kahan, T.
   Melcher, A.
TI Mechanisms of exercise-induced ST-segment depression in patients without
   typical angina pectoris
SO JOURNAL OF INTERNAL MEDICINE
LA English
DT Article
DE adrenaline; adrenoceptors; electrocardiography; exercise test; tissue
   Doppler imaging
ID CORONARY-ARTERY-DISEASE; REGIONAL DIASTOLIC FUNCTION;
   ISCHEMIC-HEART-DISEASE; TISSUE DOPPLER; STRESS ECHOCARDIOGRAPHY;
   PERFUSION SCINTIGRAPHY; MYOCARDIAL-ISCHEMIA; CHEST PAIN; SYNDROME-X;
   EPINEPHRINE
AB Background. To evaluate if exercise-induced ST-segment depression without typical angina pectoris is related to increases in sympatho-adrenal activity or beta-adrenoceptor sensitivity.
   Patients.Thirteen patients (four men) aged 35-62 years with ST-segment depression during exercise but atypical symptoms and normal myocardial scintigraphy, and 13 matched controls.
   Design and interventions. Patients and controls were compared regarding responses with: (i) exercise testing without treatment, (ii) exercise testing following beta-adrenoceptor blockade by propranolol (0.15 mg kg(-1) i.v.), (iii) incremental adrenaline infusions (0.1, 0.2, 0.4 and 0.8 nmol kg(-1) min(-1)) and (iv) adrenaline infusions during alpha-adrenoceptor blockade by phentolamine (0.5 mg min(-1)).
   Main outcome measures. ST-segment depression and tissue Doppler parameters reflecting contractility.
   Results. Exercise lowered the ST-segment by 2.44 mm without and 0.87 mm with beta-adrenoceptor blockade (P < 0.001 for difference) amongst patients, but not amongst controls. Maximal heart rate was slightly higher amongst patients (P < 0.05), despite similar loads and plasma catecholamine responses to exercise in the two groups; this difference disappeared after beta-adrenoceptor blockade with propranolol. ST-segment depression during adrenaline infusion was greater in patients compared with controls (P < 0.01) despite similar increases in heart rate. alpha-Blockade enhanced the ST-segment depression (P < 0.001) and heart rate (P < 0.001) responses to adrenaline infusion more markedly amongst patients. Tissue Doppler imaging showed similar contractility and diastolic relaxation responses of patients and controls to adrenaline, but early diastolic movements did not increase amongst patients after phentolamine (P < 0.01).
   Conclusions. Exercise-induced ST-segment depression in patients with a low likelihood of ischaemic heart disease is related to increased beta-adrenergic sensitivity regarding chronotropic and electrophysiological, but not inotropic responses.
C1 Danderyd Hosp, Karolinska Inst, Dept Clin Sci, Div Clin Physiol, Stockholm, Sweden.
   Karolinska Univ Hosp Solna, Dept Med, Clin Pharmacol Unit, SE-17176 Stockholm, Sweden.
   Danderyd Hosp, Karolinska Inst, Dept Clin Sci, Div Internal Med, Stockholm, Sweden.
C3 Karolinska Institutet; Danderyds Hospital; Karolinska Institutet;
   Karolinska University Hospital; Danderyds Hospital; Karolinska
   Institutet
RP Melcher, A (corresponding author), Karolinska Univ Hosp Solna, Dept Clin Physiol N2 01, SE-17176 Stockholm, Sweden.
EM anmelc@ki.se
RI Kahan, Thomas/JBJ-7622-2023
OI Kahan, Thomas/0000-0001-9909-4956; Hjemdahl, Paul/0000-0001-5346-275X
CR Beller GA, 2000, CIRCULATION, V101, P1465, DOI 10.1161/01.CIR.101.12.1465
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NR 29
TC 4
Z9 4
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0954-6820
EI 1365-2796
J9 J INTERN MED
JI J. Intern. Med.
PD FEB
PY 2007
VL 261
IS 2
BP 148
EP 158
DI 10.1111/j.1365-2796.2006.01751.x
PG 11
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 125XH
UT WOS:000243476300007
PM 17241180
OA Bronze
DA 2025-06-11
ER

PT J
AU Hein, M
   Lanquart, JP
   Loas, G
   Hubain, P
   Linkowski, P
AF Hein, Matthieu
   Lanquart, Jean-Pol
   Loas, Gwenole
   Hubain, Philippe
   Linkowski, Paul
TI Prevalence and Risk Factors of Type 2 Diabetes in Major Depression: A
   Study on 703 Individuals Referred for Sleep Examinations
SO PSYCHOSOMATICS
LA English
DT Article
DE Major depression; Type 2 diabetes; Prevalence; Risk factors
ID C-REACTIVE PROTEIN; EXCESSIVE DAYTIME SLEEPINESS; INFLAMMATORY MARKERS;
   MEDICATION ADHERENCE; ALCOHOL-CONSUMPTION; GENERAL-POPULATION; METABOLIC
   SYNDROME; SEX-DIFFERENCES; PRIMARY-CARE; MELLITUS
AB Background: Several studies have investigated the prevalence and risk factors of depression in individuals with type 2 diabetes. However, few studies have investigated the prevalence and risk factors for type 2 diabetes in major depression. Objective: The aim of this study was to examine the prevalence and risk factors of type 2 diabetes in a large sample of individuals with major depression. Methods: Data from 703 individuals with major depression recruited from the research database of the sleep laboratory of the Erasme Hospital were analysed. Only individuals with a diagnosis of type 2 diabetes according to the diagnostic criteria of the American Diabetes Association were included in the diabetes group. Logistic regression analyses were conducted to examine clinical and demographic risk factors of type 2 diabetes in major depression. Results: The prevalence of type 2 diabetes in major depression is 21.2%. Multivariate logistic regression analysis revealed that male sex, high blood pressure, hypertriglyceridemia, BMI >= 30 kg/m(2), age >= 50 years, sleep duration <6.5 hours, C-reactive protein >= 4.5 mgIL, Beck Depression Inventory > 12, and apnea-hypopnea index >= 51h were significant risk factors of type 2 diabetes in major depression. Conclusion: Type 2 diabetes is a common condition in major depression. In this subpopulation, most of the risk factors for type 2 diabetes are reversible, which justifies better prevention and management of this disorder to avoid its negative consequences.
C1 [Hein, Matthieu; Lanquart, Jean-Pol; Loas, Gwenole; Hubain, Philippe; Linkowski, Paul] ULB, Erasme Hosp, Dept Psychiat, B-8081070 Brussels, Belgium.
   [Hein, Matthieu; Lanquart, Jean-Pol; Loas, Gwenole; Hubain, Philippe; Linkowski, Paul] ULB, Erasme Hosp, Sleep Lab, B-8081070 Brussels, Belgium.
C3 Universite Libre de Bruxelles; Universite Libre de Bruxelles
RP Hein, M (corresponding author), ULB, Erasme Hosp, Dept Psychiat, B-8081070 Brussels, Belgium.; Hein, M (corresponding author), ULB, Erasme Hosp, Sleep Lab, B-8081070 Brussels, Belgium.
EM matthieu.hein@erasme.ulb.ac.be
RI Hein, Matthieu/IVV-2577-2023
OI Hein, Matthieu/0000-0003-4243-1653
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NR 94
TC 15
Z9 18
U1 0
U2 17
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0033-3182
EI 1545-7206
J9 PSYCHOSOMATICS
JI Psychosomatics
PD MAR-APR
PY 2018
VL 59
IS 2
BP 144
EP 157
DI 10.1016/j.psym.2017.11.003
PG 14
WC Psychiatry; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry; Psychology
GA FZ3FT
UT WOS:000427472800005
PM 29246639
DA 2025-06-11
ER

PT S
AU Oxenkrug, GF
   Summergrad, P
AF Oxenkrug, Gregory F.
   Summergrad, Paul
BE Andrews, RJ
   Slikker, W
   Trembly, B
   Patterson, TA
TI Ramelteon attenuates age-associated hypertension and weight gain in
   spontaneously hypertensive rats
SO NEUROPROTECTIVE AGENTS
SE Annals of the New York Academy of Sciences
LA English
DT Article; Proceedings Paper
CT 9th International Conference on Neuroprotective Agents
CY SEP 07-11, 2008
CL Marine Biol Lab, Woods Hole, MA
HO Marine Biol Lab
DE Ramelteon; melatonin; hypertension; weight gain; aging; age;
   spontaneously hypertensive rats; metabolic syndrome; age-associated
   neuroendocrine disorders
ID COLD-IMMOBILIZATION STRESS; MT1/MT2 RECEPTOR AGONIST; BLOOD-PRESSURE;
   VASCULAR REACTIVITY; N-ACETYLSEROTONIN; BODY-WEIGHT; MELATONIN
   RECEPTORS; REPLACEMENT THERAPY; ARTERY; WOMEN
AB The neuroendocrine theory of aging suggests the common mechanisms of developmental (prereproductive) and aging (postreproductive) processes and identified a cluster of conditions (hypertension, obesity, dyslipidemia, type 2 diabetes, menopause, late onset depression, vascular cognitive impairment, impairment of immune defense, and some forms of cancer) as age-associated neuroendocrine disorders (AAND). Obesity, dyslipidemia, hypertension, and type 2 diabetes were later described as metabolic syndrome (MetS). Because melatonin attenuated development of MetS is age-dependent, that is, in young and old, but not in middle-aged rats, we studied the effect of the selective melatonin agonist, Ramelteon, on the two core symptoms of MetS/AAND: hypertension and body weight gain in spontaneously hypertensive (SHR) and normotensive Wistar-Kyoto male rats (WKY). SHR rats developed hypertension at the time of maximal weight gain that coincided with the onset of reproductive activity (8-10 weeks old). Chronic (but not acute) administration of Ramelteon (in drinking water, 8 mg/kg/day, from 4 to 12 weeks of age) attenuated age-associated increase of systolic blood pressure (tail-cuff method) by 45%, and age-associated body weight gain by 30%. Acute and chronic Ramelteon did not affect blood pressure and body weight in normotensive WKY rats. Ramelteon-induced attenuation of age-associated hypertension and weight gain suggests that Ramelteon might attenuate the other symptoms of MetS/AAND and might be useful in the treatment of MetS/AAND during puberty, menopause, and old age.
C1 [Oxenkrug, Gregory F.] Tufts Univ, Sch Med, Dept Psychiat, Psychiat & Inflammat Program, Boston, MA 02111 USA.
   Tufts Med Ctr, Boston, MA USA.
C3 Tufts University; Tufts Medical Center
RP Oxenkrug, GF (corresponding author), Tufts Univ, Sch Med, Dept Psychiat, Psychiat & Inflammat Program, Boston, MA 02111 USA.
EM goxenkrug@tuftsmedicalcenter.org
RI Summergrad, Paul/AAI-1698-2021
OI Summergrad, Paul/0000-0001-9991-6761; Oxenkrug,
   Gregory/0000-0002-7193-9117
FU Takeda Pharmaceuticals, Inc.
FX This study was supported by a grant from Takeda Pharmaceuticals, Inc.
   The authors are thankful for the excellent technical support provided by
   Ms. S. Borochin.
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NR 60
TC 27
Z9 27
U1 0
U2 8
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN STREET, MALDEN 02148, MA USA
SN 0077-8923
BN 978-1-57331-777-1
J9 ANN NY ACAD SCI
JI Ann.NY Acad.Sci.
PY 2010
VL 1199
BP 114
EP 120
DI 10.1111/j.1749-6632.2009.05355.x
PG 7
WC Multidisciplinary Sciences; Neurosciences
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics; Neurosciences & Neurology
GA BRJ59
UT WOS:000282838900013
PM 20633116
DA 2025-06-11
ER

PT J
AU Kim, S
   Hwang, AR
   Kim, SH
   Lim, JH
   Woo, CH
AF Kim, Suji
   Hwang, Ae-Rang
   Kim, Sun-Hee
   Lim, Jae Hyang
   Woo, Chang-Hoon
TI Pentraxin 3 deficiency ameliorates streptozotocin-induced pancreatic
   toxicity via regulating ER stress and 13-cell apoptosis
SO MOLECULES AND CELLS
LA English
DT Article
DE i3-cell; Diabetes mellitus; Endoplasmic reticulum stress; Pentraxin 3
ID PTX3; INFLAMMATION
AB The long pentraxin 3 (PTX3), a marker of inflammation, has been associated with cardiovascular disease, obesity, and metabolic syndrome. Recently, elevated serum PTX3 levels have been linked to type 2 diabetes in obese patients with nonalcoholic fatty liver disease. Diabetes mellitus is a metabolic syndrome characterized by hyperglycemia resulting from insufficient insulin secretion or action. However, the precise role of PTX3 in hyperglycemia remains unclear. This study aimed to investigate the physiological roles of PTX3 in vivo. The deformation of pancreatic islets was mitigated in PTX3deficient mice treated with streptozotocin (STZ) compared to control C57BL/6J mice. In addition, PTX3 deficiency prevented STZ-induced unfolded protein responses and pancreatic 13-cell death. Immunoblotting data revealed significant inhibition of inositol-requiring protein1 alpha and C/EBP homologous protein (CHOP) protein expression in PTX3 KO mice administered tunicamycin which is a chemical endoplasmic reticulum stress inducer. Similarly, tunicamycin-induced Grp78, Grp94, ATF6, and CHOP mRNA levels were reduced in PTX3 KO mice. Moreover, recombinant PTX3-induced CHOP expression and 13-cell apoptosis in primary mouse islets. These findings suggest that PTX3 plays a critical role in STZinduced deformation of pancreatic islets via regulating endoplasmic reticulum stress and 13-cell apoptosis. (c) 2024 The Authors. Published by Elsevier Inc. on behalf of Korean Society for Molecular and Cellular Biology. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
C1 [Kim, Suji; Hwang, Ae-Rang; Kim, Sun-Hee; Woo, Chang-Hoon] Yeungnam Univ, Coll Med, Dept Pharmacol, 170 Hyeonchung Ro, Daegu 42415, South Korea.
   [Kim, Suji] Korea Natl Inst Hlth, Dept Chron Dis Convergence Res, Div Cardiovasc Dis Res, 197 Osongsaengmyeng2 Ro, Cheongju 28159, Chungcheongbuk, South Korea.
   [Lim, Jae Hyang] Ewha Womans Univ, Dept Microbiol, Coll Med, 25 Magokdong ro 2 gil, Seoul 07804, South Korea.
   [Woo, Chang-Hoon] Yeungnam Univ, Coll Med, Senotherapy Based Metab Dis Control Res Ctr, 170 Hyunchung Ro, Daegu 42415, South Korea.
C3 Yeungnam University; Korea Disease Control & Prevention Agency (KDCA);
   Korea National Institute of Health (KNIH); Ewha Womans University;
   Yeungnam University
RP Woo, CH (corresponding author), Yeungnam Univ, Coll Med, Dept Pharmacol, 170 Hyeonchung Ro, Daegu 42415, South Korea.; Lim, JH (corresponding author), Ewha Womans Univ, Dept Microbiol, Coll Med, 25 Magokdong ro 2 gil, Seoul 07804, South Korea.; Woo, CH (corresponding author), Yeungnam Univ, Coll Med, Senotherapy Based Metab Dis Control Res Ctr, 170 Hyunchung Ro, Daegu 42415, South Korea.
EM jlim19@ewha.ac.kr; changhoon_woo@y.ac.kr
FU National Research Foundation of Korea - Ministry of Science, ICT, and
   Future Planning [2022R1A5A2018865, 2021R1A2C1010851, RS-2022-00164723]
FX The present work was partly supported by the Medical Research Center
   Program (2022R1A5A2018865) and Research Program (2021R1A2C1010851,
   RS-2022-00164723) through the National Research Foundation of Korea
   funded by the Ministry of Science, ICT, and Future Planning.
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NR 28
TC 1
Z9 1
U1 1
U2 1
PU KOREAN SOC MOLECULAR & CELLULAR  BIOLOGY
PI SEOUL
PA 635-4, YUCKSAM-DONG, GANGNAM-GU, SEOUL 135-703, SOUTH KOREA
SN 1016-8478
EI 0219-1032
J9 MOL CELLS
JI Mol. Cells
PD JAN
PY 2025
VL 48
IS 1
AR 100168
DI 10.1016/j.mocell.2024.100168
EA DEC 2024
PG 8
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA U5W3L
UT WOS:001412489800001
PM 39657836
OA gold
DA 2025-06-11
ER

PT J
AU Wu, FM
   Bu, SY
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AF Wu, Fengming
   Bu, Siyuan
   Wang, Hongmei
TI Role of TRP Channels in Metabolism-Related Diseases
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE TRP channel; diabetes; hypertension; atherosclerosis; nonalcoholic fatty
   liver disease; oxidative stress
ID RECEPTOR POTENTIAL CHANNELS; FATTY LIVER-DISEASE; SMOOTH-MUSCLE-CELLS;
   ENDOTHELIUM-DEPENDENT HYPERPOLARIZATION; PANCREATIC BETA-CELLS;
   INSULIN-SECRETION; OXIDATIVE STRESS; VANILLOID TYPE-1; CATION CHANNELS;
   ACTIVATION
AB Metabolic syndrome (MetS), with its high prevalence and significant impact on cardiovascular disease, poses a substantial threat to human health. The early identification of pathological abnormalities related to MetS and prevention of the risk of associated diseases is of paramount importance. Transient Receptor Potential (TRP) channels, a type of nonselective cation channel, are expressed in a variety of tissues and have been implicated in the onset and progression of numerous metabolism-related diseases. This study aims to review and discuss the expression and function of TRP channels in metabolism-related tissues and blood vessels, and to elucidate the interactions and mechanisms between TRP channels and metabolism-related diseases. A comprehensive literature search was conducted using keywords such as TRP channels, metabolic syndrome, pancreas, liver, oxidative stress, diabetes, hypertension, and atherosclerosis across various academic databases including PubMed, Google Scholar, Elsevier, Web of Science, and CNKI. Our review of the current research suggests that TRP channels may be involved in the development of metabolism-related diseases by regulating insulin secretion and release, lipid metabolism, vascular functional activity, oxidative stress, and inflammatory response. TRP channels, as nonselective cation channels, play pivotal roles in sensing various intra- and extracellular stimuli and regulating ion homeostasis by osmosis. They present potential new targets for the diagnosis or treatment of metabolism-related diseases.
C1 [Wu, Fengming; Bu, Siyuan; Wang, Hongmei] Southeast Univ, Sch Med, Nanjing 210009, Peoples R China.
C3 Southeast University - China
RP Wang, HM (corresponding author), Southeast Univ, Sch Med, Nanjing 210009, Peoples R China.
EM 213190486@seu.edu.cn; siyuanbu@126.com; 101012573@seu.edu.cn
RI Wang, Hongmei/HGT-7374-2022
OI Wang, Hongmei/0000-0002-6975-9467
FU Zhishan Scholars Programs of Southeast University
FX We would like to extend our deepest gratitude to the editors and the
   anonymous referees for the effort they have invested in reviewing and
   critiquing our study.
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NR 207
TC 5
Z9 5
U1 3
U2 11
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD JAN
PY 2024
VL 25
IS 2
AR 692
DI 10.3390/ijms25020692
PG 30
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA GG5D0
UT WOS:001151517100001
PM 38255767
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Sun, JR
   Guo, F
   Ran, JJ
   Wu, HS
   Li, Y
   Wang, MX
   Wang, XQ
AF Sun, Jiaru
   Guo, Fang
   Ran, Jinjun
   Wu, Haisheng
   Li, Yang
   Wang, Mingxu
   Wang, Xiaoqin
TI Bibliometric and Visual Analysis of Global Research on Taurine,
   Creatine, Carnosine, and Anserine with Metabolic Syndrome: From 1992 to
   2022
SO NUTRIENTS
LA English
DT Review
DE taurine; creatine; carnosine; anserine; metabolic syndrome; bibliometric
   analysis
ID ISCHEMIC-HEART-DISEASE; UNPROCESSED RED MEAT; INSULIN-RESISTANCE;
   BODY-COMPOSITION; DOUBLE-BLIND; ANTIOXIDANT ACTIVITY;
   GROWTH-PERFORMANCE; OXIDATIVE STRESS; DIETARY TAURINE; LIPID PROFILE
AB Red meat and animal-sourced protein are often disparaged as risk factors for developing metabolic syndrome, while emerging research has shown the beneficial effects of dietary taurine, creatine, carnosine, and anserine which are all exclusively abundant in red meat. Thus, it is imperative to highlight the available evidence to help promote red meat as part of a well-balanced diet to optimize human health. In this study, a bibliometric analysis was conducted to investigate the current research status of dietary taurine, creatine, carnosine, and anserine with metabolic syndrome, identify research hotspots, and delineate developmental trends by utilizing the visualization software CiteSpace. A total of 1094 publications were retrieved via the Web of Science Core Collection from 1992 to 2022. There exists a gradual increase in the number of publications on this topic, but there is still much room for research papers to rise. The United States has participated in the most studies, followed by China and Japan. The University of Sao Paulo was the research institute contributing the most; Kyung Ja Chang and Sanya Roysommuti have been identified as the most prolific authors. The analysis of keywords reveals that obesity, lipid profiles, blood pressure, and glucose metabolism, as well as ergogenic aid and growth promoter have been the research hotspots. Inflammation and diabetic nephropathy will likely be frontiers of future research related to dietary taurine, creatine, carnosine, and anserine. Overall, this paper may provide insights for researchers to further delve into this field and enlist the greater community to re-evaluate the health effects of red meat.
C1 [Sun, Jiaru; Wang, Xiaoqin] Xi An Jiao Tong Univ, Dept Nursing, Hlth Sci Ctr, 76 Yanta West Rd, Xian 710061, Peoples R China.
   [Guo, Fang; Wu, Haisheng; Li, Yang] Univ Hong Kong, Sch Publ Hlth, Pok Fu Lam, 7 Sassoon Rd, Hong Kong, Peoples R China.
   [Ran, Jinjun] Shanghai Jiao Tong Univ, Sch Publ Hlth, Sch Med, Shanghai 200092, Peoples R China.
   [Wang, Mingxu] Xi An Jiao Tong Univ, Sch Publ Hlth, Hlth Sci Ctr, 76 Yanta West Rd, Xian 710061, Peoples R China.
C3 Xi'an Jiaotong University; University of Hong Kong; Shanghai Jiao Tong
   University; Xi'an Jiaotong University
RP Wang, XQ (corresponding author), Xi An Jiao Tong Univ, Dept Nursing, Hlth Sci Ctr, 76 Yanta West Rd, Xian 710061, Peoples R China.; Guo, F (corresponding author), Univ Hong Kong, Sch Publ Hlth, Pok Fu Lam, 7 Sassoon Rd, Hong Kong, Peoples R China.; Wang, MX (corresponding author), Xi An Jiao Tong Univ, Sch Publ Hlth, Hlth Sci Ctr, 76 Yanta West Rd, Xian 710061, Peoples R China.
EM r17691212164@163.com; guof0818@hku.hk; jinjunr@sjtu.edu.cn;
   haisheng@connect.hku.hk; yangli-01@connect.hku.hk;
   wangmx601@mail.xjtu.edu.cn; wangxiaoqin@mail.xjtu.edu.cn
RI Wu, Haisheng/GMX-3181-2022
OI Ran, Jinjun/0000-0002-2684-6341
FU Shaanxi Province Science and Technology Department [2023-YBSF-027]
FX This research was supported by Shaanxi Province Science and Technology
   Department (No. 2023-YBSF-027).
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NR 97
TC 4
Z9 5
U1 4
U2 29
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD AUG
PY 2023
VL 15
IS 15
AR 3374
DI 10.3390/nu15153374
PG 15
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA O7OZ5
UT WOS:001045673100001
PM 37571314
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Aldhafiri, FK
   Abdelgawad, FE
   Bakri, GMM
   Saber, T
AF Aldhafiri, Fahad Khalid
   Abdelgawad, Fathy Elsayed
   Bakri, Gihan Mohamed Mohamed
   Saber, Tamer
TI Thyroid Function Assessment in Saudi Males with Metabolic Syndrome
SO JOURNAL OF PHARMACY AND BIOALLIED SCIENCES
LA English
DT Article
DE Metabolic syndrome; Thyroid and thyroid dysfunction; LDL/HDL
   cholesterol; Obesity; Hypertension; Cardiovascular disease; Lipids (TG)
ID INSULIN-RESISTANCE; FREE-THYROXINE; SUBCLINICAL HYPOTHYROIDISM;
   COMPONENTS; ASSOCIATION; HORMONE; SERUM; RISK; TSH; DYSFUNCTION
AB Background: Metabolic Syndrome (MetS) is a multifactor condition associated with cardiovascular risk. Thyroid hormones regulate MetS components via controlling energy homeostasis, lipids, and glucose metabolism. The risk ratio for MetS and related disorders changes between males and females. Aim and Objectives: Study aim to access thyroid functions in Saudi population with metabolic syndrome. Materials and Methods: The current study sought to evaluate the impact of thyroid stimulating hormone (TSH), free triiodothyronine (FT3), and free thyroxine (FT4) in predicting the risk of MetS. A total of 200 (MetS 100 and control 100) Saudi Arabian males were enrolled for the study, and after applying eligibility criteria, the eligible study size was examined for the physical test (chest, abdominal, and general examination with stress on blood pressure measurement) and anthropometric parameters (bodyweight, body mass index, and waist circumference). Results: In the present study, the biochemical parameters, such as TSH, FT3, FT4, total cholesterol (TC), triglyceride (TG), high-density lipoprotein (HDL), high-density lipoprotein (LDL), fasting glucose, and fasting insulin were measured in the study group, and statistical analysis was also performed. The results revealed that the MetS and control differ in terms of physical, anthropometric, and biochemical markers. The study showed that thyroid dysfunction (TD) and MetS are closely associated with the difference in physical, anthropometric, and metabolic characteristics. Conclusion: The result demonstrated hypothyroidism major risk factor due to TD in MetS. These findings provide a scientific basis for diagnosis and the management of TD, associated MetS, and cardiovascular disease (CVD).
C1 [Aldhafiri, Fahad Khalid] Majmaah Univ Coll Appl Med Sci, Dept Publ Hlth, Al Majmaah, Saudi Arabia.
   [Abdelgawad, Fathy Elsayed] Al Azhar Univ, Fac Med, Med Biochem Dept, Cairo, Egypt.
   [Bakri, Gihan Mohamed Mohamed] Islamic Univ Madinah, Fac Sci, Dept Chem, Madinah, Saudi Arabia.
   [Bakri, Gihan Mohamed Mohamed] Univ Med Ctr, Islamic Univ Madinah, Madinah, Saudi Arabia.
   [Saber, Tamer] Zagazig Univ, Fac Med, Dept Internal Med, Zagazig, Egypt.
C3 Egyptian Knowledge Bank (EKB); Al Azhar University; Islamic University
   of Al Madinah; Islamic University of Al Madinah; Egyptian Knowledge Bank
   (EKB); Zagazig University
RP Aldhafiri, FK (corresponding author), Majmaah Univ Saudi Arabia, Appl Med Sci Coll, Publ Hlth Dept, Ind Area, Al Majmaah 15341, Saudi Arabia.
EM F.Aldhafiri@mu.edu.sa
RI Saber, Tamer/LCD-8882-2024; Abdelgawad, Fathy Elsayed/GQZ-7106-2022
OI Abdelgawad, Fathy Elsayed/0000-0002-4958-1761; Saber,
   Tamer/0000-0003-0163-2184
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NR 60
TC 3
Z9 3
U1 1
U2 1
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, Maharashtra, INDIA
SN 0975-7406
J9 J PHARM BIOALLIED SC
JI J. Pharm. Bioallied Sci.
PD OCT-DEC
PY 2021
VL 13
IS 4
BP 352
EP 359
DI 10.4103/jpbs.jpbs_745_21
PG 8
WC Pharmacology & Pharmacy
WE Emerging Sources Citation Index (ESCI)
SC Pharmacology & Pharmacy
GA 0P4US
UT WOS:000784217300003
PM 35399801
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Cox, AJ
   Zhang, P
   Evans, TJ
   Scott, RJ
   Cripps, AW
   West, NP
AF Cox, Amanda J.
   Zhang, Ping
   Evans, Tiffany J.
   Scott, Rodney J.
   Cripps, Allan W.
   West, Nicholas P.
TI Gene expression profiles in whole blood and associations with metabolic
   dysregulation in obesity
SO OBESITY RESEARCH & CLINICAL PRACTICE
LA English
DT Article
DE Metabolic syndrome; Obesity; Gene expression; Pathway analysis
ID OXIDATIVE STRESS; ADIPOSE-TISSUE; RIBOSOME BIOGENESIS; TYPE-2; CELLS;
   INFLAMMATION
AB Background: Gene expression data provides one tool to gain further insight into the complex biological interactions linking obesity and metabolic disease. This study examined associations between blood gene expression profiles and metabolic disease in obesity.
   Methods: Whole blood gene expression profiles, performed using the lllumina HT- 12v4 Human Expression Beadchip, were compared between (i) individuals with obesity (O) or lean (L) individuals (n =21 each), (ii) individuals with (M) or without (H) Metabolic Syndrome (n = 11 each) matched on age and gender. Enrichment of differentially expressed genes (DEG) into biological pathways was assessed using Ingenuity Pathway Analysis. Association between sets of genes from biological pathways considered functionally relevant and Metabolic Syndrome were further assessed using an area under the curve (AUG) and cross-validated classification rate (CR).
   Results: For OvL, only 50 genes were significantly differentially expressed based on the selected differential expression threshold (1.2-fold, p < 0.05). For MvH, 582 genes were significantly differentially expressed (1.2-fold, p < 0 05) and pathway analysis revealed enrichment of DEG into a diverse set of pathways including immune/inflammatory control, insulin signalling and mitochondrial function pathways. Gene sets from the mTOR signalling pathways demonstrated the strongest association with Metabolic Syndrome (p = 8.1 x 10(-8); AUC: 0.909, CR: 72.7%).
   Conclusions: These results support the use of expression profiling in whole blood in the absence of more specific tissue types for investigations of metabolic disease. Using a pathway analysis approach it was possible to identify an enrichment of DEG into biological pathways that could be targeted for in vitro follow-up. (c) 2017 Asia Oceania Association for the Study of Obesity. Published by Elsevier Ltd. All rights reserved.
C1 [Cox, Amanda J.; Zhang, Ping; Cripps, Allan W.; West, Nicholas P.] Griffith Univ, Menzies Hlth Inst Queensland, Parklands Dr, Southport, Qld 4215, Australia.
   [Cox, Amanda J.; West, Nicholas P.] Griffith Univ, Sch Med Sci, Southport, Qld, Australia.
   [Evans, Tiffany J.; Scott, Rodney J.] Hunter Med Res Inst, Informat Based Med Res Program, Newcastle, NSW, Australia.
   [Evans, Tiffany J.; Scott, Rodney J.] Univ Newcastle, Sch Biomed Sci & Pharm, Newcastle, NSW, Australia.
   [Cripps, Allan W.] Griffith Univ, Sch Med, Southport, Qld, Australia.
C3 Griffith University; Griffith University - Gold Coast Campus; Griffith
   University; Griffith University - Gold Coast Campus; Hunter Medical
   Research Institute; University of Newcastle; University of Newcastle;
   Griffith University; Griffith University - Gold Coast Campus
RP Cox, AJ (corresponding author), Griffith Univ, Menzies Hlth Inst Queensland, Parklands Dr, Southport, Qld 4215, Australia.
EM a.cox@griffith.edu.au
RI EVANS, TIFFANY-JANE/G-8001-2013; zhang, ping/L-3901-2017; Scott,
   Rodney/B-2827-2013
OI West, Nicholas/0000-0002-5482-4182; zhang, ping/0000-0002-3907-1127;
   Zhang, Ping/0000-0001-9163-6191; Scott, Rodney/0000-0001-7724-3404
FU Griffith University Area of Strategic Investment in Chronic Disease
   Prevention
FX The authors would like to gratefully acknowledge the cooperation of the
   trial participants. The assistance of Ms Annabelle Watts (School of
   Medical Science, Griffith University) with participant management and
   RNA extractions is appreciated, as is the assistance of Dr. Andrew
   Bulmer (School of Medical Science, Griffith University) with the
   clinical chemistry analyses. Salary support for AJC and PZ was provided
   by the Griffith University Area of Strategic Investment in Chronic
   Disease Prevention.
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NR 30
TC 5
Z9 5
U1 0
U2 3
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1871-403X
EI 1878-0318
J9 OBES RES CLIN PRACT
JI Obes. Res. Clin. Pract.
PD MAR-APR
PY 2018
VL 12
IS 2
BP 204
EP 213
DI 10.1016/j.orcp.2017.07.001
PG 10
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA GG1LJ
UT WOS:000432448200009
PM 28755841
DA 2025-06-11
ER

PT J
AU Lemaster, KA
   Farid, Z
   Brock, RW
   Shrader, CD
   Goldman, D
   Jackson, DN
   Frisbee, JC
AF Lemaster, Kent A.
   Farid, Zahra
   Brock, Robert W.
   Shrader, Carl D.
   Goldman, Daniel
   Jackson, Dwayne N.
   Frisbee, Jefferson C.
TI Altered post-capillary and collecting venular reactivity in skeletal
   muscle with metabolic syndrome
SO JOURNAL OF PHYSIOLOGY-LONDON
LA English
DT Article
DE microcirculation; metabolic syndrome; skeletal muscle blood flow; venous
   function
ID RETINAL MICROVASCULAR SIGNS; PERFUSION HETEROGENEITY; INFLAMMATORY
   RESPONSES; ARTERIOLAR DIAMETER; RESISTANCE; HYPERTENSION; ASSOCIATIONS;
   MECHANISMS; VESSELS; IMPACT
AB While research into vascular outcomes of the metabolic syndrome has focused on arterial/arteriolar and capillary levels, investigation into venular function and how this impacts responses has received little attention. Using the in situ cremaster muscle of obese Zucker rats (OZR; with lean Zucker rats (LZR) as controls), we determined indices of venular function. At approximate to 17weeks of age, skeletal muscle post-capillary venular density was reduced by approximate to 20% in LZR vs. OZR, although there was no evidence of remodelling of the venular wall. Venular tone at approximate to 25m (post-capillary) and approximate to 75m (collecting) diameter was elevated in OZR vs. LZR. Venular dilatation to acetylcholine was blunted in OZR vs. LZR due to increased oxidant stress-based loss of nitric oxide bioavailability (post-capillary) and increased (1)- (and (2)-) mediated constrictor tone (collecting). Venular constrictor responses in OZR were comparable to LZR for most stimuli, although constriction to (1)-adrenoreceptor stimulation was elevated. In response to field stimulation of the cremaster muscle (0.5, 1, 3Hz), venular dilator and hyperaemic responses to lower frequencies were blunted in OZR, but responses at 3Hz were similar between strains. Venous production of TxA(2) was higher in OZR than LZR and significantly higher than PGI(2) production in either following arachidonic acid challenge. These results suggest that multi-faceted alterations to skeletal muscle venular function in OZR may contribute to alterations in upstream capillary pressure profiles and the transcapillary exchange of solutes and water under conditions of metabolic syndrome.
C1 [Lemaster, Kent A.; Farid, Zahra; Goldman, Daniel; Jackson, Dwayne N.; Frisbee, Jefferson C.] Univ Western Ontario, Schulich Sch Med & Dent, Dept Med Biophys, Transdisciplinary Program Vasc Hlth, London, ON, Canada.
   [Brock, Robert W.] West Virginia Univ HSC, Dept Physiol & Pharmacol, Morgantown, WV USA.
   [Shrader, Carl D.] West Virginia Univ HSC, Family Med, Morgantown, WV USA.
C3 Western University (University of Western Ontario)
RP Frisbee, JC (corresponding author), Western Univ, Dept Med Biophys, Schulich Sch Med & Dent, MSB 407, London, ON N6A 5C1, Canada.
EM jfrisbee@uwo.ca
RI Jackson, Dwayne/E-4153-2015; Goldman, Daniel/CAI-2887-2022
OI Goldman, Daniel/0000-0002-8707-5536; Frisbee,
   Jefferson/0000-0003-2751-0599
FU American Heart Association [IRG 14330015, EIA 0740129N]; National
   Institutes of Health [RR 2865AR, P20 RR 016477, R01 DK64668, R01
   DK67582]; Canadian Natural Sciences and Engineering Research Council
   [NSERC R4081A03, R4218A03]
FX This study was supported by the American Heart Association (IRG
   14330015, EIA 0740129N), the National Institutes of Health (RR 2865AR;
   P20 RR 016477, R01 DK64668, R01 DK67582) and the Canadian Natural
   Sciences and Engineering Research Council (NSERC R4081A03, R4218A03).
CR [Anonymous], HDB PHYSL 2
   [Anonymous], BR J CLIN PHARM
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NR 51
TC 8
Z9 8
U1 0
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-3751
EI 1469-7793
J9 J PHYSIOL-LONDON
JI J. Physiol.-London
PD AUG 1
PY 2017
VL 595
IS 15
BP 5159
EP 5174
DI 10.1113/JP274291
PG 16
WC Neurosciences; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Physiology
GA FC2VX
UT WOS:000406698100015
PM 28556909
OA Green Published
DA 2025-06-11
ER

PT J
AU Kabir, F
   Nahar, K
   Rahman, MM
   Mamun, F
   Lasker, S
   Khan, F
   Yasmin, T
   Akter, KA
   Subhan, N
   Alam, MA
AF Kabir, Fariha
   Nahar, Kamrun
   Rahman, Md Mizanur
   Mamun, Fariha
   Lasker, Shoumen
   Khan, Ferdous
   Yasmin, Tahmina
   Akter, Khondker Ayesha
   Subhan, Nusrat
   Alam, Md Ashraful
TI Etoricoxib treatment prevented body weight gain and ameliorated
   oxidative stress in the liver of high-fat diet-fed rats
SO NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
LA English
DT Article
DE Etoricoxib; Obesity; COX-2; Metabolic syndrome; Inflammation; Oxidative
   stress
ID INSULIN-RESISTANCE; CYCLOOXYGENASE-2 INHIBITORS; CARBON-TETRACHLORIDE;
   IMMUNE CELLS; OBESITY; GLUCOSE; MICE; INFLAMMATION; CHOLESTEROL;
   CELECOXIB
AB The main focus of this study was to determine the role of etoricoxib in counterbalancing the oxidative stress, metabolic disturbances, and inflammation in high-fat (HF) diet-induced obese rats. To conduct this study, 28 male Wistar rats (weighing 190-210 g) were distributed randomly into four groups: control, control + etoricoxib, HF, and HF + etoricoxib. After 8 weeks of treatment with etoricoxib (200 mg/kg), all the animals were sacrificed followed by the collection of blood and tissue samples in order to perform biochemical tests along with histological staining on hepatic tissues. According to this study, etoricoxib treatment prevented the body weight gain in HF diet-fed rats. Furthermore, rats of HF + etoricoxib group exhibited better blood glucose tolerance than the rats of HF diet-fed group. In addition, etoricoxib also markedly normalized HF diet-mediated rise of hepatic enzyme activity. Etoricoxib treatment lowered the level of oxidative stress indicators significantly with a parallel augmentation of antioxidant enzyme activities. Furthermore, etoricoxib administration helped in preventing inflammatory cell invasion, collagen accumulation, and fibrotic catastrophe in HF diet-fed rats. The findings of the present work are suggestive of the helpful role of etoricoxib in deterring the metabolic syndrome as well as other deleterious pathological changes afflicting the HF diet-fed rats.
C1 [Kabir, Fariha; Nahar, Kamrun; Rahman, Md Mizanur; Mamun, Fariha; Lasker, Shoumen; Khan, Ferdous; Yasmin, Tahmina; Akter, Khondker Ayesha; Subhan, Nusrat; Alam, Md Ashraful] North South Univ, Dept Pharmaceut Sci, Dhaka 1219, Bangladesh.
C3 North South University (NSU)
RP Alam, MA (corresponding author), North South Univ, Dept Pharmaceut Sci, Dhaka 1219, Bangladesh.
EM sonaliagun@yahoo.com
RI Mamun, Fariha/AAR-7070-2020; Nahar, Dr.Kamrun/JFS-9212-2023; Khan,
   Ferdous/MDS-9680-2025; Alam, Ashraful/G-1964-2014; Rahman, Md
   Mizanur/AAC-7666-2019
OI Kabir, Fariha/0000-0001-6412-5257; Alam, Md
   Ashraful/0000-0001-7596-5868; Rahman, Md Mizanur/0000-0002-7178-7977
FU Department of Pharmaceutical Sciences, North South University,
   Bangladesh
FX The authors appreciate all the supports provided by the Department of
   Pharmaceutical Sciences, North South University, Bangladesh, where the
   research work was conducted.
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   Yan HY, 2003, J LIPID RES, V44, P424, DOI 10.1194/jlr.M200357-JLR200
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NR 56
TC 5
Z9 5
U1 0
U2 2
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0028-1298
EI 1432-1912
J9 N-S ARCH PHARMACOL
JI Naunyn-Schmiedebergs Arch. Pharmacol.
PD JAN
PY 2021
VL 394
IS 1
BP 33
EP 47
DI 10.1007/s00210-020-01960-9
EA AUG 2020
PG 15
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA PN1PW
UT WOS:000558624900002
PM 32780227
DA 2025-06-11
ER

PT J
AU Catoi, AF
   Pârvu, AE
   Andreicut, AD
   Mironiuc, A
   Craciun, A
   Catoi, C
   Pop, ID
AF Catoi, Adriana Florinela
   Parvu, Alina Elena
   Andreicut, Andra Diana
   Mironiuc, Aurel
   Craciun, Alexandra
   Catoi, Cornel
   Pop, Ioana Delia
TI Metabolically Healthy versus Unhealthy Morbidly Obese: Chronic
   Inflammation, Nitro-Oxidative Stress, and Insulin Resistance
SO NUTRIENTS
LA English
DT Article
DE metabolically healthy morbidly obese; metabolically unhealthy morbidly
   obese; metabolic syndrome; chronic inflammation; nitro-oxidative stress;
   insulin-resistance
ID BARIATRIC SURGERY; ADIPOSE-TISSUE; NORMAL-WEIGHT; RISK-FACTORS;
   INDIVIDUALS; CHEMERIN; PREVALENCE; MECHANISMS; BIOMARKERS; ADIPOKINE
AB Metabolically heathy obesity is characterised by the presence of obesity in the absence of metabolic disturbances. The aim of our study was to analyse pro-inflammatory, nitro-oxidative stress, and insulin-resistance (IR) markers in metabolically healthy morbidly obese (MHMO) with respect to metabolically unhealthy morbidly obese (MUHMO) with metabolic syndrome (MS) and to identify the potential predictors of MS in the MHMO group. Two groups of MHMO and MUHMO with MS were analysed. We evaluated serum high sensitivity C reactive protein (hsCRP), tumor necrosis factor alpha (TNF-), chemerin, nitrite and nitrate (NOx), total oxidant status (TOS), total antioxidant response (TAR), fasting blood glucose, insulin, and homeostasis model assessment of insulin resistance (HOMA-IR.) MHMO have similar hsCRP and TNF- values as the MUHMO with MS, while chemerin was significantly lower in MHMO. NOx was higher in MUHMO with MS patients, while no difference regarding TOS and TAR was found between the two groups. HOMA-IR and insulin values were lower in MHMO as compared to the MUHMO with MS group. Insulin, HOMA-IR, and chemerin were identified predictors of MS in MHMO. In conclusion, MHMO and MUHMO display similarities and differences in terms of chronic inflammation, nitro-oxidative stress, and IR. Markers of IR and chemerin are possible predictors of MS in MHMO.
C1 [Catoi, Adriana Florinela; Parvu, Alina Elena; Andreicut, Andra Diana] Iuliu Hatieganu Univ Med & Pharm, Fac Med, Dept Pathophysiol, Cluj Napoca 400012, Romania.
   [Mironiuc, Aurel] Iuliu Hatieganu Univ Med & Pharm, Fac Med, Surg Clin 2, Cluj Napoca 400012, Romania.
   [Craciun, Alexandra] Iuliu Hatieganu Univ Med & Pharm, Fac Med, Dept Biochem, Cluj Napoca 400012, Romania.
   [Catoi, Cornel] Univ Agr Sci & Vet Med, Fac Vet Med, Dept Pathol, Cluj Napoca 400012, Romania.
   [Pop, Ioana Delia] Univ Agr Sci & Vet Med, Fac Hort, Dept Exact Sci, Cluj Napoca 400012, Romania.
C3 Iuliu Hatieganu University of Medicine & Pharmacy; Iuliu Hatieganu
   University of Medicine & Pharmacy; Iuliu Hatieganu University of
   Medicine & Pharmacy; University of Agricultural Sciences & Veterinary
   Medicine Cluj Napoca; University of Agricultural Sciences & Veterinary
   Medicine Cluj Napoca
RP Catoi, AF (corresponding author), Iuliu Hatieganu Univ Med & Pharm, Fac Med, Dept Pathophysiol, Cluj Napoca 400012, Romania.
EM florinela12@yahoo.com; parvualinaelena@umfcluj.ro;
   cecan.andra@umfcluj.ro; aurel.mironiuc@umfcluj.ro; acraciun@umfcluj.ro;
   cornel.catoi@usamvcluj.ro; popioana@usamvcluj.ro
RI Cornel, Catoi/KLC-4257-2024; POP, Ioana/C-3717-2008; Craciun, Alexandra
   M/G-5762-2011
OI Pop, Ioana Delia/0000-0002-6167-8232; Craciun, Alexandra
   M/0000-0003-3703-1874; Parvu, Alina Elena/0000-0001-8937-8517
FU European Social Fund, Human Resources Development Operational Programme
   2007-2013 [POSDRU/159/1.5/S/138776]; "Iuliu Hatieganu" University of
   Medicine and Pharmacy, Cluj-Napoca, Romania [27020/39/15.11.2011]
FX This research was funded by the European Social Fund, Human Resources
   Development Operational Programme 2007-2013, project no.
   POSDRU/159/1.5/S/138776 and by internal research grant no.
   27020/39/15.11.2011 of "Iuliu Hatieganu" University of Medicine and
   Pharmacy, Cluj-Napoca, Romania.
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NR 56
TC 63
Z9 66
U1 0
U2 9
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD SEP
PY 2018
VL 10
IS 9
AR 1199
DI 10.3390/nu10091199
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA GY5YI
UT WOS:000448659900072
PM 30200422
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Fernandes, R
   Bento, CF
   Matafome, P
   Sena, CM
   Seiça, RM
   Pereira, P
AF Fernandes, Rosa
   Bento, Carla F.
   Matafome, Paulo
   Sena, Cristina M.
   Seica, Raquel M.
   Pereira, Paulo
TI Atorvastatin-mediated protection of the retina in a model of diabetes
   with hyperlipidemia
SO CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
LA English
DT Article
DE diabetic retinopathy; statins; proteasome; oxidative stress; atherogenic
   diet
ID UBIQUITIN-PROTEASOME PATHWAY; GOTO-KAKIZAKI RAT; OXIDATIVE STRESS;
   INSULIN-RESISTANCE; ENDOTHELIAL-CELLS; METABOLIC SYNDROME; RETINOPATHY;
   GLUCOSE; DEGRADATION; STATINS
AB Insulin resistance, a key feature of obesity, metabolic syndrome, and type 2 diabetes mellitus (T2DM), results in a variety of metabolic and vascular abnormalities. Metabolic disturbances associated with diabetes could contribute to disrupting the structural and (or) functional integrity of the retina. The effects of atorvastatin on retinal cells in hyperlipidemic T2DM rats have not yet been investigated. We used Goto-Kakizaki (GK) rats fed with an atherogenic diet (AD) for 4 months to investigate whether atorvastatin (administered for 1 month) would slow-down or reverse the progression of lesions in the diabetic retina. Fluorogenic substrates were used to measure the proteasome activities in retinal cells. The production of reactive oxygen species was determined by immunofluorescence in frozen retina sections, using dihydroethydium. Nitrotyrosine levels were assessed using immunohistochemistry. Protein levels of ubiquitin conjugates, free ubiquitin, and ubiquitin activating enzyme E1 were determined with Western blotting. Atorvastatin significantly reduced the levels of oxidative stress that were induced by the AD and restored the proteasome activities in the diabetic GK rats. Atorvastatin therapy significantly improved local oxidative stress levels in GK rats fed with AD. Atorvastatin can, at least in part, restore the ubiquitin proteasome system, and may represent a pharmacological approach to prevent some of the complications associated with diabetic retinopathy.
C1 [Fernandes, Rosa; Bento, Carla F.; Pereira, Paulo] Univ Coimbra, Fac Med, Inst Biomed Imaging & Life Sci IBILI, Ctr Opththalmol & Vis Sci, P-3000548 Coimbra, Portugal.
   [Fernandes, Rosa] Univ Coimbra, Fac Med, Inst Biomed Imaging & Life Sci IBILI, Lab Pharmacol & Expt Therapeut, P-3000548 Coimbra, Portugal.
   [Matafome, Paulo; Sena, Cristina M.; Seica, Raquel M.] Univ Coimbra, Fac Med, Inst Biomed Imaging & Life Sci IBILI, Physiol Lab, P-3000548 Coimbra, Portugal.
C3 Universidade de Coimbra; Universidade de Coimbra; Universidade de
   Coimbra
RP Fernandes, R (corresponding author), Univ Coimbra, Fac Med, Inst Biomed Imaging & Life Sci IBILI, Ctr Opththalmol & Vis Sci, P-3000548 Coimbra, Portugal.
EM rcfernandes@fmed.uc.pt
RI Pereira, Paulo/AAD-8375-2022; Matafome, Paulo/AAQ-4113-2020; Sena,
   Cristina/N-2494-2013; Fernandes, Rosa/P-1102-2014
OI Pereira, Paulo/0000-0002-9908-2290; Seica, Raquel/0000-0002-8378-0895;
   Matafome, Paulo/0000-0002-3422-290X; Sena, Cristina/0000-0002-0889-2977;
   Fernandes, Rosa/0000-0001-7828-2296; Bento, Carla F./0000-0001-8377-4543
FU Portuguese Foundation for Science and Technology (FCT)
   [PTDC/SAU-ORG/113542/2009, Pest-C/SAU/UI3282/2011]; Fundação para a
   Ciência e a Tecnologia [PTDC/SAU-ORG/113542/2009] Funding Source: FCT
FX This work was supported by grants from the Portuguese Foundation for
   Science and Technology (FCT): PTDC/SAU-ORG/113542/2009 and
   Pest-C/SAU/UI3282/2011. Conflict of interest statement: The authors
   declare that they have no conflicts of interest associated with this
   work.
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NR 49
TC 13
Z9 16
U1 0
U2 15
PU CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS
PI OTTAWA
PA 65 AURIGA DR, SUITE 203, OTTAWA, ON K2E 7W6, CANADA
SN 0008-4212
EI 1205-7541
J9 CAN J PHYSIOL PHARM
JI Can. J. Physiol. Pharmacol.
PD DEC
PY 2014
VL 92
IS 12
BP 1037
EP 1043
DI 10.1139/cjpp-2014-0212
PG 7
WC Pharmacology & Pharmacy; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Physiology
GA AU4DG
UT WOS:000345558600008
PM 25404034
DA 2025-06-11
ER

PT J
AU Metoki, H
AF Metoki, Hirohito
TI The Significance of Observing the Risk of Non-communicable Diseases
   after Large-scale Disasters and Communicable Disease Epidemics
SO JMA JOURNAL
LA English
DT Review
DE Non -communicable diseases; COVID-19; disasters; cohort study; biobank
ID GREAT EAST JAPAN; EARTHQUAKE
AB Non-communicable diseases (NCDs) are a global challenge, accounting for 71% of all deaths worldwide. The spread of coronavirus disease 2019 (COVID-19) and past huge disasters have affected the prevention and treatment of NCDs and require urgent action. In this narrative review, I will discuss several reports on the risk of NCDs during past disasters and propose possible future directions. Hypertension, the most common NCD, carries a high risk of death due to cerebrovascular, renal, and other complications. Effective use of information and communication technology-based telemedicine is necessary to manage the risk of cardiovascular diseases during disasters and pandemics. We observed the cumulative incidence of metabolic syndrome in subjects from tsunami-affected areas. We found that moving into prefabricated temporary housing was a risk factor for a higher incidence of metabolic syndrome in elderly females. Our follow-up of 1,009 subjects showed a slight, but significant, increase in HbA1c values after a state of emergency was introduced, even though the lockdown was not as stringent as in other countries. In a study elucidating the prevalence of wheezing and eczema symptoms and the associated factors after the Great East Japan Earthquake, psychological effects, such as depression and self-reported posttraumatic stress disorder, were observed, particularly in people with allergic diseases. In recent years, new birth cohort studies have been initiated to complement the studies designed to collect information across multiple generations, such as the Lifelines study in the Netherlands and the Avon Longitudinal Study of Parents and Children (ALSPAC) study in the UK. It is desirable to assess the effects of COVID-19 to complement the existing cohort studies in Japan as well.
C1 [Metoki, Hirohito] Tohoku Med & Pharmaceut Univ, Div Publ Hlth Hyg & Epidemiol, Sendai, Japan.
   [Metoki, Hirohito] Tohoku Univ, Dept Prevent Med cine & Epidemiol, Tohoku Med Megabank Org, Sendai, Japan.
C3 Tohoku Medical & Pharmaceutical University; Tohoku University
RP Metoki, H (corresponding author), Tohoku Med & Pharmaceut Univ, Div Publ Hlth Hyg & Epidemiol, Sendai, Japan.; Metoki, H (corresponding author), Tohoku Univ, Dept Prevent Med cine & Epidemiol, Tohoku Med Megabank Org, Sendai, Japan.
EM hmetoki@tohoku-mpu.ac.jp
RI Metoki, Hirohito/B-3376-2009
FU Medical Research Encouragement Prize of The Japan Medical Association
FX This work was supported by Medical Research Encouragement Prize of The
   Japan Medical Association
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NR 40
TC 4
Z9 4
U1 0
U2 1
PU JAPAN MEDICAL ASSOC-JAPANESE ASSOC MEDICAL SCIENCES
PI TOKYO
PA 2-28-16 HONKOMAGOME, BUNKYO-KU, TOKYO, 113-8621, JAPAN
SN 2433-328X
EI 2433-3298
J9 JMA J
JI JMA J.
PD OCT 15
PY 2021
VL 4
IS 4
BP 305
EP 310
DI 10.31662/jmaj.2021-0126
PG 6
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA FY9E3
UT WOS:001149524700007
PM 34796284
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Jalali, MM
   Dalili, S
   Koohmanaee, S
   Rad, S
AF Jalali, Mir Mohammad
   Dalili, Setila
   Koohmanaee, Shahin
   Rad, Samira
TI The Role of Metabolic Syndrome Components in Sensorineural Hearing Loss
   in Adolescents: A Case-Control Study
SO INTERNATIONAL ARCHIVES OF OTORHINOLARYNGOLOGY
LA English
DT Article
DE sensorineural hearing loss; metabolic syndrome; triglycerides;
   adolescent
ID NUTRITION EXAMINATION SURVEY; PLASMA ADIPONECTIN LEVELS; TYPE-2
   DIABETES-MELLITUS; CARDIOVASCULAR-DISEASE; OXIDATIVE STRESS; IRANIAN
   CHILDREN; NATIONAL-HEALTH; DYSFUNCTION; PREVALENCE; STATEMENT
AB Introduction Metabolic syndrome (MetS) and its associated components were reported as a possible cause of inner ear dysfunction. However, research about the influence of cardiovascular risk factors on hearing thresholds are conducted mainly in adult patients. Objective The aim of the present study was to investigate auditory function in adolescents with MetS compared with healthy controls.
   Methods One hundred adolescents with metabolic syndrome and 200 sex- and agematched controls were recruited from a university pediatric endocrine clinic from May 2018 to July 2020. Hearing loss was defined as hearing level >= 15 dB at speech frequency (SFHL) or high frequency (HFHL) in one or both ears. A multivariable conditional logistic regression analysis examined the correlation between MetS components and several important demographic characteristics, and hearing loss.
   Results A total of 165 (55.0%) boys and 135 (45.0%) girls participated in this study. The rates of SFHL and HFHL in adolescents withMetS were 32.0% and 51.0%, respectively. Those values for controls were 5.0% and 15.5%, respectively. The regression analysis showed high triglycerides as a significant predictor for SFHL (odds ratio 10.87; 95% confidence interval: 1.98, 59.74). Neither predictor of interest was significant for HFHL.
   Conclusion Hypertriglyceridemia may be an important factor in the pathogenesis of SFHL. However, the strength of the association was not significant with a wide confidence interval. Also, we were unable to find an association between predictors and HFHL with the current sample size. Larger and prospective studies are recommended.
C1 [Jalali, Mir Mohammad] Guilan Univ Med Sci, Otorhinolaryngol Res Ctr, Sch Med, Dept Otolaryngol, Rasht, Iran.
   [Dalili, Setila; Koohmanaee, Shahin; Rad, Samira] Guilan Univ Med Sci, Pediat Res Ctr, Sch Med, Dept Pediat Endocrinol & Metab, Rasht, Iran.
   [Jalali, Mir Mohammad] Guilan Univ Med Sci, Amiralmomenin Hosp, Dept Otolaryngol, Rasht, Iran.
C3 Guilan University of Medical Sciences; Guilan University of Medical
   Sciences; Guilan University of Medical Sciences
RP Jalali, MM (corresponding author), Guilan Univ Med Sci, Amiralmomenin Hosp, Dept Otolaryngol, Rasht, Iran.
EM mmjalali@gmail.com
RI koohmanaee, shahin/K-7200-2017; Jalali, mir/G-3640-2017
OI Rad, Samira/0000-0003-4981-4454
CR Ahmadi N, 2020, IRAN J PUBLIC HEALTH, V49, P360, DOI 10.18502/ijph.v49i2.3106
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NR 47
TC 2
Z9 2
U1 0
U2 1
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 1809-9777
EI 1809-4864
J9 INT ARCH OTORHINOLAR
JI Int. Arch. Otorhinolaryngol.
PD JUL
PY 2023
VL 27
IS 03
BP 393
EP 399
DI 10.1055/s-0041-1742241
PG 7
WC Otorhinolaryngology
WE Emerging Sources Citation Index (ESCI)
SC Otorhinolaryngology
GA O3OR5
UT WOS:001042949400004
PM 37564469
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Zhao, YT
   Sedighi, R
   Wang, P
   Chen, HD
   Zhu, YD
   Sang, SM
AF Zhao, Yantao
   Sedighi, Rashin
   Wang, Pei
   Chen, Huadong
   Zhu, Yingdong
   Sang, Shengmin
TI Carnosic Acid as a Major Bioactive Component in Rosemary Extract
   Ameliorates High-Fat-Diet-Induced Obesity and Metabolic Syndrome in Mice
SO JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
LA English
DT Article
DE rosemary; carnosic acid; obesity; metabolic syndrome; high-fat diet;
   oxidative stress
ID ROSMARINUS-OFFICINALIS L.; GLYCATION END-PRODUCTS; LIMITS WEIGHT-GAIN;
   HEPATIC STEATOSIS; PROTEIN GLYCATION; LIVER; DISEASE; PLANT
AB In this study, we investigated the preventive effects of carnosic acid (CA) as a major bioactive component in rosemary extract (RE) on high-fat-diet-induced obesity and metabolic syndrome in mice. The mice were given a low-fat diet, a high-fat diet or a high-fat diet supplemented with either 0.14% or 0.28% (w/w) CA-enriched RE (containing 80% CA, REAM and RE#1H), or 0.5% (w/w) RE (containing 45% CA, RE#2), for a period of 16 weeks. There was the same CA content in the RE#1H and RE#2 diets and half of this amount in the RE#1L diet. The dietary RE supplementation significantly reduced body weight gain, percent of fat, plasma ALT, AST, glucose, insulin levels, liver weight, liver triglyceride, and free fatty acid levels in comparison with the mice fed with a HF diet without RE treatment. RE administration also decreased the levels of plasma and liver malondialdehyde, advanced glycation end products (AGEs), and the liver expression of receptor for AGE (RAGE) in comparison with those for mice of the HF group. Histological analyses of liver samples showed decreased lipid accumulation in hepatocytes in mice administrated with RE in comparison with that of HF-diet-fed mice. Meanwhile, RE administration enhanced fecal lipid excretion to inhibit lipid absorption and increased the liver GSH/GSSG ratio to perform antioxidant activity compared with HF group. Our results demonstrate that rosemary is a promising dietary agent to reduce the risk of obesity and metabolic syndrome.
C1 [Zhao, Yantao; Sedighi, Rashin; Wang, Pei; Chen, Huadong; Zhu, Yingdong; Sang, Shengmin] North Carolina Agr & Tech State Univ, Ctr Excellence Postharvest Technol, Kannapolis, NC 28081 USA.
C3 University of North Carolina; North Carolina A&T State University
RP Sang, SM (corresponding author), North Carolina Agr & Tech State Univ, Ctr Excellence Postharvest Technol, North Carolina Res Campus,500 Laureate Way, Kannapolis, NC 28081 USA.
EM ssang@ncat.edu
RI Sang, Shengmin/AFK-9982-2022; Chen, Huadong/H-2272-2013
OI Zhao, Yantao/0000-0003-0722-195X
FU USDA National Institute of Food and Agriculture [2011-38821-31131]
FX This study was supported by funding from the USDA National Institute of
   Food and Agriculture (Grant No. 2011-38821-31131) to S.S.
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NR 39
TC 94
Z9 98
U1 0
U2 49
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0021-8561
EI 1520-5118
J9 J AGR FOOD CHEM
JI J. Agric. Food Chem.
PD MAY 20
PY 2015
VL 63
IS 19
BP 4843
EP 4852
DI 10.1021/acs.jafc.5b01246
PG 10
WC Agriculture, Multidisciplinary; Chemistry, Applied; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture; Chemistry; Food Science & Technology
GA CJ0GS
UT WOS:000355154400018
PM 25929334
DA 2025-06-11
ER

PT J
AU Lteif, A
   Mather, K
AF Lteif, A
   Mather, K
TI Insulin resistance, metabolic syndrome and vascular diseases: Update on
   mechanistic linkages
SO CANADIAN JOURNAL OF CARDIOLOGY
LA English
DT Article; Proceedings Paper
CT Advances in Vascular Biology Symposium
CY AUG 14-17, 2003
CL Vancouver, CANADA
SP Pfizer Canada
DE asymmetric dimethylarginine; endothelin; insulin resistance; metabolic
   syndrome; nitric oxide; risk factors; tetrahydrobiopterin
ID C-REACTIVE PROTEIN; NITRIC-OXIDE SYNTHASE; PLASMINOGEN-ACTIVATOR
   INHIBITOR; CORONARY-HEART-DISEASE; TUMOR-NECROSIS-FACTOR;
   ENDOTHELIUM-DEPENDENT VASODILATION; TYPE-2 DIABETES-MELLITUS;
   POLYCYSTIC-OVARY-SYNDROME; CARDIOVASCULAR RISK-FACTORS;
   FRUCTOSE-HYPERTENSIVE RATS
AB Epidemiological associations are now well-established between insulin resistance, the metabolic syndrome and worsened cardiovascular outcomes. A direct role of insulin in vascular biology is also now broadly recognized. Specifically, insulin can directly stimulate the action of nitric oxide synthase, an effect that can be demonstrated both in vitro and in vivo. Insulin resistance, whether present endogenously or produced experimentally through exposure to fatty acids, glucosamine or turnout necrosis factor alpha, is associated with impaired endothelium-dependent vasodilation and, specifically, with impaired insulin-stimulated vasodilation. A number of potential molecular explanations for these observations are being pursued, with evidence to support a number of concurrent pathogenic mechanisms. These include insulin resistance-associated reductions in nitric oxide availability due to increases in oxidative stress (not requiring the presence of hyperglycemia), reduced availability of tetrahydrobiopterin and excess levels of asymmetrical dimethylarginine. A strong body of evidence also supports an excess of the vasoconstrictor endothelin, which may result directly from hyperinsulinemia and/or indirectly due to a loss of the suppressive effects of nitric oxide on endothelin production and action. The current leading edge of investigations into the association between insulin-resistant states and vascular dysfunction involves the expanding repertoire of adipocyte-derived hormones. Of these, particular interest has been focused on adiponectin, which has both vascular and metabolic actions, and may contribute importantly to the connection between metabolism and vascular function. Progress along these novel lines of investigation will continue to expand the understanding of the mechanisms linking insulin resistance, the metabolic syndrome and vascular disease.
C1 Indiana Univ, Sch Med, Indianapolis, IN 46204 USA.
C3 Indiana University System; Indiana University Indianapolis
RP 975 W Walnut St,IB424, Indianapolis, IN 46202 USA.
EM kmather@iupui.edu
RI Mather, Kieren/ABE-4117-2020
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NR 179
TC 22
Z9 38
U1 1
U2 7
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0828-282X
EI 1916-7075
J9 CAN J CARDIOL
JI Can. J. Cardiol.
PD AUG
PY 2004
VL 20
SU B
BP 66B
EP 76B
PG 11
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Cardiovascular System & Cardiology
GA 847UL
UT WOS:000223420600011
PM 15309208
DA 2025-06-11
ER

PT J
AU Sun, MX
   Huang, XQ
   Yan, Y
   Chen, JF
   Wang, ZZ
   Xie, MH
   Li, J
AF Sun, Mingxiao
   Huang, Xiuqing
   Yan, Yi
   Chen, Junfei
   Wang, Zhengzhen
   Xie, Minhao
   Li, Jian
TI Rac1 Is a Possible Link Between Obesity and Oxidative Stress in Chinese
   Overweight Adolescents
SO OBESITY
LA English
DT Article
ID INTIMA-MEDIA THICKNESS; INSULIN SENSITIVITY; METABOLIC SYNDROME; NADPH
   OXIDASE; GLUCOSE-TOLERANCE; HUMAN MONOCYTES; ANGIOTENSIN-II; CHILDREN;
   EXERCISE; AGE
AB Enhanced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity in the monocytes occurred in metabolic syndrome, hypertension, diabetes and obese patients in adults. However, whether NADPH oxidase is involved in the oxidative stress of overweight adolescents without comorbidities is still unclear. This study aimed to identify whether and how NADPH oxidase plays a crucial role in overweight adolescents. The study was performed in 93 overweight adolescents and 31 normal weight controls. Moreover, 87 overweight adolescents were enrolled in weight-loss program. Demographics characteristics, anthropometrics, composition and clinical characteristics were analyzed. Oxidative stress indexes including the levels of superoxide dismutase (SOD) and malondialdehyde (MDA) in plasma and the expression of NADPH oxidase in the monocytes were examined. Overweight adolescents showed a higher oxidative stress state, as indicated by decreased SOD activity and elevated MDA level (P < 0.01). Furthermore, increased NADPH oxidase activity in the monocytes was accompanied by Rac1 upregulation. A significant positive bivariate correlation was found between Rac1 expression and MDA (r = 0.289). There also was a significant positive bivariate correlation between Rac1 expression and obesity-related indexes including BMI (r = 0.227) and percentage of trunk fat (r = 0.233). Data from weight-loss program reinforced the results. Partial correlation analysis indicated that obesity-induced oxidative stress and Rac1 expression is a consequence of aberrant glucose-lipid metabolism in overweight adolescents. In conclusion, we provided novel data showing that NADPH oxidase in the monocytes was highly activated by enhancing Rac1 expression in Chinese overweight adolescents and Rac1 may act as a link between obesity and oxidative stress in overweight adolescents.
C1 [Sun, Mingxiao] Beijing Hosp, Key Lab Geriatr, Dept Endocrinol, Beijing, Peoples R China.
   [Sun, Mingxiao; Huang, Xiuqing; Li, Jian] Minist Hlth, Beijing Inst Geriatr, Beijing, Peoples R China.
   [Yan, Yi; Chen, Junfei; Wang, Zhengzhen; Xie, Minhao] Beijing Sports Univ, Sports Sci Coll, Beijing, Peoples R China.
C3 Beijing Hospital; Beijing Sport University
RP Li, J (corresponding author), Beijing Hosp, Key Lab Geriatr, Dept Endocrinol, Beijing, Peoples R China.
EM lijian@bjhmoh.cn
RI Junfei, Chen/K-7574-2012
FU National Basic Research Program of China [2012CB 517502]; National
   Social Science foundation; The Ministry of Education of China
   [BLA060052]; National Natural Science foundation of China [81070634,
   30801218]; National Natural Science Foundation of Beijing [7092090]
FX This project was funded by National Basic Research Program of China
   (2012CB 517502), National Social Science foundation, The Ministry of
   Education of China (BLA060052), National Natural Science foundation of
   China (81070634, 30801218), National Natural Science Foundation of
   Beijing (7092090).
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NR 24
TC 16
Z9 16
U1 0
U2 8
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 1930-7381
J9 OBESITY
JI Obesity
PD NOV
PY 2012
VL 20
IS 11
BP 2233
EP 2240
DI 10.1038/oby.2012.63
PG 8
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 029JS
UT WOS:000310492200010
PM 22421922
OA Bronze
DA 2025-06-11
ER

PT J
AU Kontoangelos, K
   Papageorgiou, CC
   Raptis, AE
   Tsiotra, P
   Lambadiari, V
   Papadimitriou, GN
   Rabavilas, AD
   Dimitriadis, G
   Raptis, SA
AF Kontoangelos, K.
   Papageorgiou, C. C.
   Raptis, A. E.
   Tsiotra, P.
   Lambadiari, V.
   Papadimitriou, G. N.
   Rabavilas, A. D.
   Dimitriadis, G.
   Raptis, S. A.
TI Homocysteine, Cortisol, Diabetes Mellitus, and Psychopathology
SO JOURNAL OF DIABETES RESEARCH
LA English
DT Article
ID CARDIOVASCULAR RISK-FACTORS; PLASMA HOMOCYSTEINE; METABOLIC SYNDROME;
   DEPRESSION; ASSOCIATION; SCHIZOPHRENIA; TRAITS; STRESS; FOLATE
AB Objective. This study investigates the association of homocysteine and cortisol with psychological factors in type 2 diabetic patients. Method. Homocysteine, cortisol, and psychological variables were analyzed from 131 diabetic patients. Psychological factors were assessed with the Eysenck Personality Questionnaire (EPQ), Hostility and Direction of Hostility Questionnaire (HDHQ), the Symptom Checklist 90-R (SCL 90-R), the Zung Self-Rating Depression Scale (ZDRS), and the Maudsley O-C Inventory Questionnaire (MOCI). Blood samples were taken by measuring homocysteine and cortisol in both subgroups during the initial phase of the study (T0). One year later (T1), the uncontrolled diabetic patients were reevaluated with the use of the same psychometric instruments and with an identical blood analysis. Results. The relation of psychoticism and homocysteine is positive among controlled diabetic patients (P value = 0.006 < 0.05) and negative among uncontrolled ones (P value = 0.137). Higher values of cortisol correspond to lower scores on extraversion subscale (r(p) = -0.223, P value = 0.010). Controlled diabetic patients showed a statistically significant negative relationship between homocysteine and the act-out hostility subscale (r(sp) = -0.247, P = 0.023). There is a statistically significant relationship between homocysteine and somatization (r(sp) = -0.220, P = 0.043). Conclusions. These findings support the notion that homocysteine and cortisol are related to trait and state psychological factors in patients with diabetes mellitus type 2.
C1 [Kontoangelos, K.; Papageorgiou, C. C.; Papadimitriou, G. N.] Univ Athens, Eginit Hosp, Sch Med, Dept Psychiat 1, GR-11528 Athens, Greece.
   [Kontoangelos, K.; Papageorgiou, C. C.; Rabavilas, A. D.] Univ Mental Hlth Res Inst, Athens 11527, Greece.
   [Raptis, A. E.; Lambadiari, V.; Dimitriadis, G.; Raptis, S. A.] Univ Athens, Sch Med, Attikon Univ Hosp, Dept Internal Med 2,Res Inst, Athens 12462, Greece.
   [Raptis, A. E.; Lambadiari, V.; Dimitriadis, G.; Raptis, S. A.] Univ Athens, Sch Med, Attikon Univ Hosp, Ctr Diabet, Athens 12462, Greece.
   [Tsiotra, P.; Raptis, S. A.] Hellen Natl Ctr Res Prevent & Treatment Diabet Me, Athens 10675, Greece.
C3 Athens Medical School; National & Kapodistrian University of Athens;
   Athens Medical School; University Hospital Attikon; National &
   Kapodistrian University of Athens; University Hospital Attikon; National
   & Kapodistrian University of Athens; Athens Medical School
RP Kontoangelos, K (corresponding author), Univ Athens, Eginit Hosp, Sch Med, Dept Psychiat 1, GR-11528 Athens, Greece.
EM kontange@hol.gr
RI Tsiotra, Panayoula/AAE-6086-2019
OI Papageorgiou, Charalabos/0000-0001-7635-1956
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NR 42
TC 12
Z9 12
U1 1
U2 6
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2314-6745
EI 2314-6753
J9 J DIABETES RES
JI J. Diabetes Res.
PY 2015
VL 2015
AR 354923
DI 10.1155/2015/354923
PG 10
WC Endocrinology & Metabolism; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Research & Experimental Medicine
GA CB6ZX
UT WOS:000349776700001
PM 25722989
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Cherniack, EP
AF Cherniack, E. Paul
TI A berry thought-provoking idea: the potential role of plant polyphenols
   in the treatment of age-related cognitive disorders
SO BRITISH JOURNAL OF NUTRITION
LA English
DT Review
DE Fruits; Polyphenols; Cognition; Ageing
ID SUPPLEMENTATION IMPROVES MEMORY; NEURONAL SIGNAL-TRANSDUCTION; GREEN TEA
   POLYPHENOL; METABOLIC SYNDROME; BLUEBERRY SUPPLEMENTATION; DIETARY
   SUPPLEMENTATION; OXIDATIVE STRESS; HISTONE ACETYLATION; BEHAVIORAL
   DEFICITS; OLDER-ADULTS
AB Today, tens of millions of elderly individuals worldwide suffer from dementia. While the pathogenesis of dementia is complex and incompletely understood, it may be, at least to a certain extent, the consequence of systemic vascular pathology. The metabolic syndrome and its individual components induce a proinflammatory state that damages blood vessels. This condition of chronic inflammation may damage the vasculature of the brain or be directly neurotoxic. Associations have been established between the metabolic syndrome, its constituents and dementia. A relationship has also been observed between certain dietary factors, such as constituents of the 'Mediterranean diet', and the metabolic syndrome; similar associations have been noted between these dietary factors and dementia. Fruit juices and extracts are under investigation as treatments for cognitive impairment. Blueberry, strawberry, blackberry, grape and plum juices or extracts have been successfully tested in cognitively impaired rodents. Published trials of the benefits of grape and blueberry juice in the treatment of small numbers of cognitively impaired persons have recently appeared. The benefits of fruit products are thought to be a result of its polyphenol content. A grape polyphenol found in grapes, resveratrol, now being studied in humans, and one in grapes and blueberries, pterostilbene, have been found to improve cognition in rodents. In the design of future human trials, one ought to consider the poor bioavailability of these products, the possible need to initiate the experimental therapy long before the onset of symptoms, and currently limited knowledge about the appropriate form (e.g. juice, powder or individual polyphenol) of treatment.
C1 [Cherniack, E. Paul] Univ Miami, Sch Med,Miami Vet Affairs Med Ctr, Div Geriatr & Gerontol, Geriatr Inst,Geriatr & Extended Care Serv, Miami, FL 33125 USA.
   [Cherniack, E. Paul] Univ Miami, Sch Med, Miami Vet Affairs Med Ctr, Geriatr Res Educ & Clin Ctr, Miami, FL 33125 USA.
C3 University of Miami; Geriatric Research Education & Clinical Center;
   University of Miami
RP Cherniack, EP (corresponding author), Univ Miami, Sch Med,Miami Vet Affairs Med Ctr, Div Geriatr & Gerontol, Geriatr Inst,Geriatr & Extended Care Serv, Room 1D200,1201 NW 16th St, Miami, FL 33125 USA.
EM evan.cherniack@va.gov
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NR 82
TC 50
Z9 55
U1 0
U2 72
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1145
EI 1475-2662
J9 BRIT J NUTR
JI Br. J. Nutr.
PD SEP 14
PY 2012
VL 108
IS 5
BP 794
EP 800
DI 10.1017/S0007114512000669
PG 7
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 000DB
UT WOS:000308365600005
PM 22475317
DA 2025-06-11
ER

PT J
AU Wu, T
   Sun, JN
   Kagota, S
   Maruyama, K
   Wakuda, H
   Shinozuka, K
AF Wu, Ting
   Sun, Jianning
   Kagota, Satomi
   Maruyama, Kana
   Wakuda, Hirokazu
   Shinozuka, Kazumasa
TI Panax notoginseng saponins ameliorate impaired arterial vasodilation in
   SHRSP.Z-Lepr<SUP>fa</SUP>/lzmDmcr rats with metabolic syndrome
SO CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
LA English
DT Article
DE metabolic syndrome; nitric oxide; Panax notoginseng saponins;
   vasodilation
ID SHR/NDMCR-CP RATS; ANIMAL-MODEL; ATHEROSCLEROTIC LESIONS; DYSFUNCTION;
   EXPRESSION; TELMISARTAN; RECEPTORS; ZYMOSAN; STRESS; INJURY
AB Panax notoginseng saponins (PNS) are major components of Panax notoginseng, a herb with established clinical efficacyagainst vascular diseases. SHRSP.Z-Lepr(fa)/IzmDmcr (SHRSP.ZF) rats, a new animal model for metabolic syndrome, display an impaired vasorelaxation response in aortas and mesenteric arteries that is mediated by nitric oxide (NO). This study investigated whether PNS and its components can ameliorate this vascular dysfunction in SHRSP.ZF rats. In an invitro study, in the presence or absence of PNS and its components, vasodilation in response to nitroprusside was determined from myographs under isometric tension conditions in aortas and mesenteric arteries from male SHRSP.ZF rats at 18-20weeks of age. In an invivo study, PNS (30mg/kg per day) was orally administered to SHRSP.ZF rats from 8 to 20weeks of age. In vitro treatment with PNS and Ginsenoside Rb-1 increased nitroprusside-induced relaxation of aortas and mesenteric arteries in SHRSP.ZF rats. The PNS-induced increase was not affected by a nitric oxide (NO) synthase inhibitor or endothelium denudation. Relaxation in response to a cell-permeable cGMP analogue was increased by PNS, but cGMP accumulation by nitroprusside was not altered. In vivo treatment with PNS in SHRSP.ZF rats lowered blood pressure and increased relaxation and the expression of soluble guanylyl cyclase protein in arteries, without affecting metabolic abnormalities. These results indicate that PNS causes an increase in vasodilation in response to NO and a decrease in blood pressure, resulting in protection against vascular dysfunction in SHRSP.ZF rats. PNS might be beneficial in alleviating impaired vasodilation in metabolic syndrome.
C1 [Wu, Ting; Sun, Jianning] Beijing Univ Chinese Med, Sch Chinese Mat Med, Beijing, Peoples R China.
   [Kagota, Satomi; Maruyama, Kana; Wakuda, Hirokazu; Shinozuka, Kazumasa] Mukogawa Womens Univ, Sch Pharm & Pharmaceut Sci, Dept Pharmacol, Nishinomiya, Hyogo 6638179, Japan.
C3 Beijing University of Chinese Medicine; Mukogawa Women's University
RP Kagota, S (corresponding author), Mukogawa Womens Univ, Sch Pharm & Pharmaceut Sci, Dept Pharmacol, Nishinomiya, Hyogo 6638179, Japan.
EM skagota@mukogawa-u.ac.jp
RI Wakuda, Hirokazu/KZU-6319-2024
OI Wakuda, Hirokazu/0000-0002-5717-8251
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NR 39
TC 12
Z9 12
U1 0
U2 19
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0305-1870
EI 1440-1681
J9 CLIN EXP PHARMACOL P
JI Clin. Exp. Pharmacol. Physiol.
PD APR
PY 2016
VL 43
IS 4
BP 459
EP 467
DI 10.1111/1440-1681.12547
PG 9
WC Pharmacology & Pharmacy; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Physiology
GA DH6KX
UT WOS:000372900500008
PM 26784885
DA 2025-06-11
ER

PT J
AU Fürst-Recktenwald, S
   Dörr, HG
   Quinkler, M
   Dötsch, J
   Stewart, PM
AF Fuerst-Recktenwald, Sabine
   Doerr, Helmuth G.
   Quinkler, Marcus
   Doetsch, Joerg
   Stewart, Paul M.
TI Is there sufficient evidence to consider the use of 11β-hydroxysteroid
   dehydrogenase type 1 inhibition in children?
SO CLINICAL ENDOCRINOLOGY
LA English
DT Review
ID CORTISONE-REDUCTASE DEFICIENCY; MESSENGER-RNA EXPRESSION;
   ADIPOSE-TISSUE; GROWTH-HORMONE; HEXOSE-6-PHOSPHATE DEHYDROGENASE;
   METABOLIC SYNDROME; HEALTHY-CHILDREN; IN-VIVO; MODULATION; OBESITY
AB Manifestations of the metabolic syndrome [obesity, dyslipidaemia, hypertension, blood glucose derangements including prediabetes or type 2 diabetes mellitus (T2DM)] in juvenile populations are becoming increasingly prevalent throughout the world and are at the point of being a global public health concern. Derangements in cortisol regeneration seem to be involved in the pathophysiology. Treatment with selective 11 beta-hydroxysteroid dehydrogenase 1 (11 beta-HSD1) inhibitors could be a therapeutic strategy in paediatric patients with manifestations of the metabolic syndrome. Based on preclinical and clinical data regarding development of the 11 beta-HSD1 enzyme, it appears that maturation occurs within the first year of life. Different changes in biomarkers for assessing the efficacy and safety of 11 beta-HSD1 inhibitors are to be expected in paediatric patients compared to adults, reflecting differences in metabolism. The effect of 11 beta-HSD1 treatment in children on bone differentiation and development as well as adrenocorticotropic hormone (ACTH), circulating and local cortisol tissue concentrations, androgens and respective stress response is not yet known. Based on current literature, the concept of inhibition of 11 beta-HSD1 is considered a potentially effective mean to regulate local cortisol levels in the paediatric population, and 11 beta-HSD1 inhibitors may provide a valuable target and treatment option for the metabolic syndrome in paediatric patients. However, the uncertainty over effects on the developing skeleton combined with mild increases in adrenal androgen levels raises potential concerns regarding growth as well as onset of puberty as to their future use in children. Future clinical studies are needed to thoroughly assess the risks and benefits of this new class of drugs in the paediatric population.
C1 [Fuerst-Recktenwald, Sabine] F Hoffmann La Roche Ltd, Basel, Switzerland.
   [Doerr, Helmuth G.] Univ Erlangen Nurnberg, Dept Pediat, D-91054 Erlangen, Germany.
   [Quinkler, Marcus] Charite, Charite Campus Mitte, D-13353 Berlin, Germany.
   [Doetsch, Joerg] Univ Cologne, Dept Pediat, D-50931 Cologne, Germany.
   [Stewart, Paul M.] Univ Birmingham, Sch Clin & Expt Med, Birmingham, W Midlands, England.
C3 Roche Holding; University of Erlangen Nuremberg; Berlin Institute of
   Health; Free University of Berlin; Humboldt University of Berlin;
   Charite Universitatsmedizin Berlin; University of Cologne; University of
   Birmingham
RP Fürst-Recktenwald, S (corresponding author), F Hoffmann La Roche Ltd, Basel, Switzerland.
EM sabine.fuerst-recktenwald@roche.com
RI Doerr, Helmuth/LYO-3879-2024
OI Quinkler, Marcus/0000-0003-4028-1671
FU F. Hoffmann-La Roche Ltd.
FX Medical writing support was funded by F. Hoffmann-La Roche Ltd.
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NR 67
TC 0
Z9 0
U1 0
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0300-0664
EI 1365-2265
J9 CLIN ENDOCRINOL
JI Clin. Endocrinol.
PD AUG
PY 2012
VL 77
IS 2
BP 159
EP 168
DI 10.1111/j.1365-2265.2012.04406.x
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 971SF
UT WOS:000306223400001
PM 22486586
OA Bronze
DA 2025-06-11
ER

PT J
AU Meguro, K
   Svensson, T
   Chung, UI
   Svensson, AK
AF Meguro, Keiko
   Svensson, Thomas
   Chung, Ung-il
   Svensson, Akiko K.
TI Associations of work-related stress and total sleep time with
   cholesterol levels in an occupational cohort of Japanese office workers
SO JOURNAL OF OCCUPATIONAL HEALTH
LA English
DT Article
DE cholesterol level; occupational cohort; the Brief Job Stress
   Questionnaire; total sleep time; wearable device
ID CARDIOVASCULAR-DISEASE; DURATION; RISK; MEN
AB Objective The aim of the study was to investigate the associations of total sleep time (TST) and occupational stress based on the Brief Job Stress Questionnaire (BJSQ) with cholesterol levels in an occupational cohort of Japanese office workers. Methods The present study is a secondary analysis of a subset of participants from a randomized controlled trial. Participants were 179 employees from 5 companies in Tokyo who participated as the intervention group in a 3-month lifestyle intervention study among office workers with metabolic syndrome or at risk of metabolic syndrome. All intervention-group participants used a mobile app and a wearable device. The final population for analysis in the present study were 173 participants. Cholesterol measures were derived from participants' annual health check-up data in the fiscal year preceding their inclusion in the study. Multiple linear regression models were used to determine the association between exposures and outcome. Results Overall, stress levels were significantly and inversely associated with LDL-C (-7.12 mg/dl; 95% CI: -11.78, -2.45) and LDL-C/HDL-C ratio (-0.16 mg/dl; 95% CI: -0.27, -0.04) per standard deviation increase. Compared to average TST 5.9-7.2 hours, average TST of 4.0-5.3 hours (-4.82 mg/dl; 95% CI: -9.22, -0.43) was inversely associated with HDL-C. Conclusion Incremental increases of stress were significantly and inversely associated with LDL-C and LDL-C/HDL-C ratio. The shortest average TST was inversely associated with HDL-C. The results should be interpreted with care given certain methodological limitations.
C1 [Meguro, Keiko; Svensson, Thomas; Chung, Ung-il; Svensson, Akiko K.] Univ Tokyo, Precis Hlth, Dept Bioengn, Grad Sch Engn,Bunkyo Ku, 7-3-1 Hongo, Tokyo 1138655, Japan.
   [Meguro, Keiko; Svensson, Thomas; Chung, Ung-il] Kanagawa Univ, Sch Hlth Innovat, Human Serv Grad Sch, Kawasaki, Kanagawa, Japan.
   [Svensson, Thomas; Svensson, Akiko K.] Lund Univ, Skane Univ Hosp, Dept Clin Sci, Malmo, Sweden.
   [Chung, Ung-il] Univ Tokyo, Ctr Dis Biol & Integrat Med, Grad Sch Med, Clin Biotechnol, Tokyo, Japan.
   [Svensson, Akiko K.] Univ Tokyo, Dept Diabet & Metab Dis, Bunkyo Ku, Tokyo, Japan.
C3 University of Tokyo; Lund University; Skane University Hospital;
   University of Tokyo; University of Tokyo
RP Svensson, T (corresponding author), Univ Tokyo, Precis Hlth, Dept Bioengn, Grad Sch Engn,Bunkyo Ku, 7-3-1 Hongo, Tokyo 1138655, Japan.
EM thomas.svensson@med.lu.se
RI Svensson, Thomas/AAJ-4578-2020
OI Meguro, Keiko/0000-0002-1259-143X
FU Center of Innovation Program from the Japan Science and Technology
   Agency, JST [JPMJCE1304]; Kanagawa prefecture's "A project to expand the
   use of metabolic syndrome risk index in municipalities" (2018)
FX This research was supported by the Center of Innovation Program from the
   Japan Science and Technology Agency, JST (Grant Number JPMJCE1304) and
   Kanagawa prefecture's "A project to expand the use of metabolic syndrome
   risk index in municipalities" (2018).
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NR 38
TC 2
Z9 2
U1 0
U2 14
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1341-9145
EI 1348-9585
J9 J OCCUP HEALTH
JI J. Occup. Health
PD JAN
PY 2021
VL 63
IS 1
AR e12275
DI 10.1002/1348-9585.12275
PG 10
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA WK7SW
UT WOS:000709924200001
PM 34679211
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Wolf, EJ
   Morrison, FG
   Sullivan, DR
   Logue, MW
   Guetta, RE
   Stone, A
   Schichman, SA
   McGlinchey, RE
   Milberg, WP
   Miller, MW
AF Wolf, Erika J.
   Morrison, Filomene G.
   Sullivan, Danielle R.
   Logue, Mark W.
   Guetta, Rachel E.
   Stone, Annjanette
   Schichman, Steven A.
   McGlinchey, Regina E.
   Milberg, William P.
   Miller, Mark W.
TI The goddess who spins the thread of life: Klotho, psychiatric stress,
   and accelerated aging
SO BRAIN BEHAVIOR AND IMMUNITY
LA English
DT Article
ID METHYLATION AGE ASSOCIATIONS; LEUKOCYTE TELOMERE LENGTH; DNA
   METHYLATION; METABOLIC SYNDROME; EPIGENETIC AGE; CEREBROSPINAL-FLUID;
   FUNCTIONAL VARIANT; OXIDATIVE STRESS; TRAUMA EXPOSURE; GENE-EXPRESSION
AB Background: Longevity gene klotho (KL) is associated with age-related phenotypes but has not been evaluated against a direct human biomarker of cellular aging. We examined KL and psychiatric stress, including posttraumatic stress disorder (PTSD), which is thought to potentiate accelerated aging, in association with biomarkers of cellular aging.
   Methods: The sample comprised 309 white, non-Hispanic genotyped veterans with measures of epigenetic age (DNA methylation age), telomere length (n = 252), inflammation (C-reactive protein), psychiatric symptoms, metabolic function, and white matter neural integrity (diffusion tensor imaging; n = 185). Genotyping and DNA methylation were obtained on epi/genome-wide beadchips.
   Results: In gene by environment analyses, two KL variants (rs9315202 and rs9563121) interacted with PTSD severity (peak corrected p = 0.044) and sleep disturbance (peak corrected p = 0.034) to predict advanced epigenetic age. KL variant, rs398655, interacted with self-reported pain in association with slowed epigenetic age (corrected p = 0.048). A well-studied protective variant, rs9527025, was associated with slowed epigenetic age (p = 0.046). The peak PTSD interaction term (with rs9315202) also predicted C-reactive protein (p = 0.049), and white matter microstructural integrity in two tracts (corrected ps = 0.005 - 0.035). This SNP evidenced a main effect with an index of metabolic syndrome severity (p = 0.015). Effects were generally accentuated in older subjects.
   Conclusions: Rs9315202 predicted multiple biomarkers of cellular aging such that psychiatric stress was more strongly associated with cellular aging in those with the minor allele. KL genotype may contribute to a synchronized pathological aging response to stress and could be a therapeutic target to alter the pace of cellular aging.
C1 [Wolf, Erika J.; Morrison, Filomene G.; Sullivan, Danielle R.; Logue, Mark W.; Guetta, Rachel E.; Miller, Mark W.] VA Boston Healthcare Syst, Natl Ctr PTSD, 150 South Huntington Ave, Boston, MA 02130 USA.
   [Wolf, Erika J.; Morrison, Filomene G.; Sullivan, Danielle R.; Logue, Mark W.; Miller, Mark W.] Boston Univ, Sch Med, Dept Psychiat, Boston, MA 02215 USA.
   [Logue, Mark W.] Boston Univ, Sch Med, Dept Med, Biomed Genet, Boston, MA 02215 USA.
   [Logue, Mark W.] Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA USA.
   [Stone, Annjanette; Schichman, Steven A.] Cent Arkansas Vet Healthcare Syst, Pharmacogenom Anal Lab, Res Serv, Little Rock, AR USA.
   [McGlinchey, Regina E.; Milberg, William P.] VA Boston Healthcare Syst, Geriatr Res Educ & Clin Ctr, Boston, MA USA.
   [McGlinchey, Regina E.; Milberg, William P.] VA Boston Healthcare Syst, Translat Res Ctr TBI & Stress Disorders, Boston, MA USA.
   [McGlinchey, Regina E.; Milberg, William P.] Harvard Med Sch, Dept Psychiat, Boston, MA 02115 USA.
C3 Harvard University; Harvard University Medical Affiliates; US Department
   of Veterans Affairs; Veterans Health Administration (VHA); VA Boston
   Healthcare System; Boston University; Boston University; Boston
   University; US Department of Veterans Affairs; Veterans Health
   Administration (VHA); Central Arkansas Veterans Healthcare System;
   Geriatric Research Education & Clinical Center; Harvard University;
   Harvard University Medical Affiliates; US Department of Veterans
   Affairs; Veterans Health Administration (VHA); VA Boston Healthcare
   System; Harvard University; Harvard University Medical Affiliates; US
   Department of Veterans Affairs; Veterans Health Administration (VHA); VA
   Boston Healthcare System; Harvard University; Harvard Medical School
RP Wolf, EJ (corresponding author), VA Boston Healthcare Syst, Natl Ctr PTSD, 150 South Huntington Ave, Boston, MA 02130 USA.
EM Erika.Wolf@va.gov
RI ; Miller, Mark/G-7322-2011
OI Guetta, Rachel/0000-0002-7271-9917; Sullivan, Danielle
   R./0000-0002-0141-5887; Miller, Mark/0000-0001-6393-8563; Wolf,
   Erika/0000-0003-2666-2435
FU National Institute on Aging [R03AG051877]; United States (U.S.)
   Department of Veterans Affairs Clinical Sciences R&D (CSRD) Service
   Merit Review Award [I01 CX-001276-01]; National Institute of Mental
   Health [5T32MH019836-18, R21MH102834]; VA CSR&D Career Development Award
   [1 IK2 CX001772-01]; VA BLRD Merit Award [1I01BX003477-01]; Presidential
   Early Career Award for Scientists and Engineers (PECASE 2013A);
   Translational Research Center for TBI and Stress Disorders (TRACTS), a
   VA Rehabilitation Research and Development Traumatic Brain Injury Center
   of Excellence [B9254-C]; Cooperative Studies Program, Department of
   Veterans Affairs
FX This work was supported by the National Institute on Aging [grant number
   R03AG051877 (EJW)], United States (U.S.) Department of Veterans Affairs
   Clinical Sciences R&D (CSRD) Service Merit Review Award [grant number
   I01 CX-001276-01 (EJW)], National Institute of Mental Health [grant
   number 5T32MH019836-18 (FGM)], National Institute of Mental Health
   [grant number R21MH102834 (MWM), VA CSR&D Career Development Award
   [grant number 1 IK2 CX001772-01 (DRS)], and VA BLR&D Merit Award [grant
   number 1I01BX003477-01 (MWL)]. This work was also supported by a
   Presidential Early Career Award for Scientists and Engineers (PECASE
   2013A) to EJW, as administered by U.S. Department of Veterans Affairs
   Office of Research and Development and by the Translational Research
   Center for TBI and Stress Disorders (TRACTS), a VA Rehabilitation
   Research and Development Traumatic Brain Injury Center of Excellence
   (B9254-C), and the Cooperative Studies Program, Department of Veterans
   Affairs. This research is the result of work supported with resources
   and the use of facilities at the Pharmacogenomics Analysis Laboratory,
   Research and Development Service, Central Arkansas Veterans Healthcare
   System, Little Rock, Arkansas, and the National Center for PTSD. The
   contents of this manuscript do not represent the views of the U.S.
   Department of Veterans Affairs, the National Institutes of Health, or
   the United States Government.
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NR 99
TC 31
Z9 33
U1 0
U2 6
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0889-1591
EI 1090-2139
J9 BRAIN BEHAV IMMUN
JI Brain Behav. Immun.
PD AUG
PY 2019
VL 80
BP 193
EP 203
DI 10.1016/j.bbi.2019.03.007
PG 11
WC Immunology; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Immunology; Neurosciences & Neurology; Psychiatry
GA IM6LX
UT WOS:000478105500020
PM 30872092
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Horn, P
   Newsome, PN
AF Horn, Paul
   Newsome, Phlip N.
TI Emerging therapeutic targets for NASH: key innovations at the
   preclinical level
SO EXPERT OPINION ON THERAPEUTIC TARGETS
LA English
DT Review
DE Bone-morphogenetic proteins; endoplasmic reticulum stress; inflammasome;
   lipid metabolism; nonalcoholic fatty liver disease; nonalcoholic
   steatohepatitis; platelets; pyroptosis; treatment
ID COA CARBOXYLASE INHIBITION; REDUCES HEPATIC STEATOSIS; DE-NOVO
   LIPOGENESIS; NONALCOHOLIC STEATOHEPATITIS; ER STRESS;
   LIVER-REGENERATION; INFLAMMASOME ACTIVATION; GLUCOSE-METABOLISM;
   INSULIN-RESISTANCE; UP-REGULATION
AB Introduction: nonalcoholic steatohepatitis (NASH) is a globally emerging health problem, mainly caused by increasing trends in the prevalence of obesity and metabolic syndrome. Patients with NASH are mainly affected by cardiovascular risk and extrahepatic cancer, but a significant proportion of patients will develop advanced liver disease, eventually resulting in liver failure or hepatocellular carcinoma. Recent research has yielded a better understanding of the underlying mechanisms and potential targetability for drug development. Areas covered: This review focuses on the role of fructose metabolism, de novo lipogenesis (DNL), endoplasmic reticulum (ER) stress, NLRP3 inflammasome, bone morphogenetic protein (BMP) signaling and platelets in the pathophysiology of NASH. We discuss the suitability of these substrates for targeting liver disease as well as cardiovascular health in patients with NASH. A non-systematic literature search was performed on PubMed and ClinicalTrials.gov. Expert opinion: Targeting fructose metabolism, DNL, ER stress, NLRP3 inflammasome, BMP signaling and platelets are promising therapeutic strategies, warranting further preclinical and clinical investigation. The discussed approaches might not only benefit liver-related outcomes but improve cardiovascular disease as well. Amidst the euphoria of advances in drug development for NASH, parallel endeavors need to address the underlying causes of obesity and metabolic syndrome to prevent NASH.
C1 [Horn, Paul; Newsome, Phlip N.] Univ Hosp Birmingham NHS Fdn Trust, Natl Inst Hlth Res Birmingham Biomed Res Ctr, Birmingham, W Midlands, England.
   [Horn, Paul; Newsome, Phlip N.] Univ Birmingham, Birmingham, W Midlands, England.
   [Horn, Paul; Newsome, Phlip N.] Univ Birmingham, Inst Immunol & Immunotherapy, Ctr Liver & Gastrointestinal Res, Birmingham, W Midlands, England.
   [Horn, Paul; Newsome, Phlip N.] Univ Hosp Birmingham NHS Fdn Trust, Liver Unit, Birmingham, W Midlands, England.
C3 University of Birmingham; University of Birmingham; University of
   Birmingham; University of Birmingham
RP Newsome, PN (corresponding author), Univ Birmingham, Ctr Liver & Gastrointestinal Res, Birmingham B15 2TT, W Midlands, England.; Newsome, PN (corresponding author), Univ Birmingham, Inst Immunol & Immunotherapy, Hepatol, Birmingham B15 2TT, W Midlands, England.
EM p.n.newsome@bham.ac.uk
RI Horn, Paul/O-6885-2015; Newsome, Philip/D-4495-2018
OI Horn, Paul/0000-0002-8755-7703; Newsome, Philip/0000-0001-6085-3652
FU University Hospitals Birmingham NHS Foundation Trust [BRC-1215-20009]
FX The work of the authors has received funding from University Hospitals
   Birmingham NHS Foundation Trust grant [BRC-1215-20009].
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   2019, HEPATOLOGY, V70, P1
NR 111
TC 9
Z9 9
U1 0
U2 18
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1472-8222
EI 1744-7631
J9 EXPERT OPIN THER TAR
JI Expert Opin. Ther. Targets
PD MAR 3
PY 2020
VL 24
IS 3
BP 175
EP 186
DI 10.1080/14728222.2020.1728742
EA FEB 2020
PG 12
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA KU5VL
UT WOS:000513793600001
PM 32053033
DA 2025-06-11
ER

PT J
AU Castro, JP
   Grune, T
   Speckmann, B
AF Castro, Jose Pedro
   Grune, Tilman
   Speckmann, Bodo
TI The two faces of reactive oxygen species (ROS) in adipocyte function and
   dysfunction
SO BIOLOGICAL CHEMISTRY
LA English
DT Review
DE adipogenesis; adipose tissue dysregulation; antioxidants; metabolic
   disorders; oxidative stress
ID ACTIVATED RECEPTOR-GAMMA; SELENOPROTEIN P EXPRESSION; WHITE
   ADIPOSE-TISSUE; FREE-RADICAL THEORY; INSULIN-RESISTANCE; OXIDATIVE
   STRESS; METABOLIC SYNDROME; OXIDIZED PROTEINS; HYDROGEN-PEROXIDE;
   ANATOMIC SITE
AB White adipose tissue (WAT) is actively involved in the regulation of whole-body energy homeostasis via storage/ release of lipids and adipokine secretion. Current research links WAT dysfunction to the development of metabolic syndrome (MetS) and type 2 diabetes (T2D). The expansion of WAT during oversupply of nutrients prevents ectopic fat accumulation and requires proper preadipocyte-to-adipocyte differentiation. An assumed link between excess levels of reactive oxygen species (ROS), WAT dysfunction and T2D has been discussed controversially. While oxidative stress conditions have conclusively been detected in WAT of T2D patients and related animal models, clinical trials with antioxidants failed to prevent T2D or to improve glucose homeostasis. Furthermore, animal studies yielded inconsistent results regarding the role of oxidative stress in the development of diabetes. Here, we discuss the contribution of ROS to the (patho) physiology of adipocyte function and differentiation, with particular emphasis on sources and nutritional modulators of adipocyte ROS and their functions in signaling mechanisms controlling adipogenesis and functions of mature fat cells. We propose a concept of ROS balance that is required for normal functioning of WAT. We explain how both excessive and diminished levels of ROS, e. g. resulting from over supplementation with antioxidants, contribute to WAT dysfunction and subsequently insulin resistance.
C1 [Castro, Jose Pedro; Grune, Tilman] German Ctr Diabet Res DZD, Ingolstadter Landstr 1, D-85764 Munich, Germany.
   [Castro, Jose Pedro] Univ Porto, Dept Expt Biol, Fac Med, Alameda Prof Hernani Monteiro, P-4200319 Oporto, Portugal.
   [Castro, Jose Pedro] Inst Innovat & Hlth Res, Aging & Stress Grp, R Alfredo Allen, P-4200135 Oporto, Portugal.
   [Grune, Tilman] Univ Potsdam, Inst Nutr Sci, Dept Physiol & Pathophysiol, Arthur Scheunert Allee 114-116, D-14558 Nuthetal, Germany.
   [Grune, Tilman] German Ctr Cardiovasc Res DZHK, Postfach 65 21 33, D-13353 Berlin, Germany.
   [Speckmann, Bodo] German Inst Human Nutr Potsdam Rehbrucke, Dept Mol Toxicol, Arthur Scheunert Allee 114-116, D-14558 Nuthetal, Germany.
C3 German Center for Diabetes Research (DZD); Universidade do Porto;
   University of Potsdam; German Centre for Cardiovascular Research;
   Leibniz Association; Deutsches Institut fur Ernahrungsforschung
   Potsdam-Rehbrucke (DIfE)
RP Castro, JP (corresponding author), German Ctr Diabet Res DZD, Ingolstadter Landstr 1, D-85764 Munich, Germany.; Castro, JP (corresponding author), Univ Porto, Dept Expt Biol, Fac Med, Alameda Prof Hernani Monteiro, P-4200319 Oporto, Portugal.; Castro, JP (corresponding author), Inst Innovat & Hlth Res, Aging & Stress Grp, R Alfredo Allen, P-4200135 Oporto, Portugal.
EM jose.castro@dife.de
OI Grune, Tilman/0000-0003-4775-9973; Castro, Jose
   Pedro/0000-0002-2627-5331
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NR 139
TC 114
Z9 122
U1 1
U2 28
PU WALTER DE GRUYTER GMBH
PI BERLIN
PA GENTHINER STRASSE 13, D-10785 BERLIN, GERMANY
SN 1431-6730
EI 1437-4315
J9 BIOL CHEM
JI Biol. Chem.
PD AUG
PY 2016
VL 397
IS 8
BP 709
EP 724
DI 10.1515/hsz-2015-0305
PG 16
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA DQ9ES
UT WOS:000379513800002
PM 27031218
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Lv, DD
   Han, N
   Yuan, M
   Huang, W
   Yan, LB
   Tang, H
AF Lv, Duoduo
   Han, Ning
   Yuan, Man
   Huang, Wei
   Yan, Libo
   Tang, Hong
TI Depression and the risk of non-alcohol fatty liver disease: Results from
   a cross-sectional study and a Mendelian randomization analysis
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Depression; Non-alcohol fatty liver disease; Cross-sectional study;
   NHANES; Mendelian randomization
ID METABOLIC SYNDROME; ASSOCIATION; NAFLD; INFLAMMATION; MANAGEMENT;
   BEHAVIORS; DIAGNOSIS; GUIDANCE
AB Background: Previous studies have suggested that psychiatric factors may be pathogenic for NAFLD. However, the association between depression and NAFLD is not been consistent, and whether depression plays a causal role in the development of NAFLD remains unclear. Methods: We extracted data from the National Health and Nutrition Examination Survey (NHANES) 2017-2018 to assess the correlation between depression and NAFLD risk. Based on previous genome-wide association studies (GWAS) meta-analyses on NAFLD and depression, we performed a Mendelian randomization (MR) analysis to explore the causal effect of depression on NAFLD. The primary analysis method used in the MR analysis was inverse variance weighted. Results: We ultimately extracted the data from 3878 individuals in the NHANES database to perform the crosssectional study. Multivariable-adjusted logistic regression showed that depressed individuals had a higher risk of NAFLD than controls (odds ratio [OR] 1.33, 95 % CI 1.03-1.72, p = 0.027) among women. Based on GWAS data, we included 36 genetic variants as instrumental variables to estimate the causal effect of depression on NAFLD risk. The MR analysis revealed a causal association between genetically predicted depression and an increased risk of NAFLD (OR = 1.504, 95 % CI 1.13-2.00, p = 0.005). Limitations: The consistency of these findings in Eastern populations requires further longitudinal studies. Conclusions: This cross-sectional study suggested that depression might increase the risk of NAFLD in women. The MR analysis demonstrated that there exists a causal association between genetically predicated depression and NAFLD risk.
C1 [Lv, Duoduo; Han, Ning; Yuan, Man; Huang, Wei; Yan, Libo; Tang, Hong] Sichuan Univ, West China Hosp, Ctr Infect Dis, 37 Guoxue Alley, Chengdu 610041, Sichuan, Peoples R China.
   [Lv, Duoduo; Han, Ning; Huang, Wei; Yan, Libo; Tang, Hong] Sichuan Univ, Div Infect Dis, State Key Lab Biotherapy, Chengdu 610041, Sichuan, Peoples R China.
C3 Sichuan University; Sichuan University
RP Yan, LB; Tang, H (corresponding author), Sichuan Univ, West China Hosp, Ctr Infect Dis, 37 Guoxue Alley, Chengdu 610041, Sichuan, Peoples R China.
EM yanlibo@wchscu.cn; tanghong6198@wchscu.cn
RI Yan, Libo/H-2328-2012; Yuan, Man/KYO-7421-2024
FU National Key Research and Devel-opment Program of China
   [2022YFC2304800]; The 1.3.5 project for disciplines of excellence, West
   China Hospital, Sichuan University [ZYGD23030]; Science and Technology
   project of the Health Commission of Sichuan Province [23009]
FX This work was supported by the National Key Research and Devel-opment
   Program of China (No. 2022YFC2304800) , the 1.3.5 project for
   disciplines of excellence, West China Hospital, Sichuan University (No.
   ZYGD23030) and the Science and Technology project of the Health
   Commission of Sichuan Province (No.23009) .
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NR 56
TC 3
Z9 3
U1 7
U2 20
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD DEC 1
PY 2024
VL 366
BP 300
EP 307
DI 10.1016/j.jad.2024.08.189
EA SEP 2024
PG 8
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA F7F3K
UT WOS:001311429800001
PM 39216642
DA 2025-06-11
ER

PT J
AU Morales-Avila, UM
   Yahia, EM
   Montalvo-González, R
   Becerra-Verdín, EM
   Montalvo-González, E
AF Mireya Morales-Avila, Ursula
   Yahia, Elhadi M.
   Montalvo-Gonzalez, Ruben
   Mendeleev Becerra-Verdin, Eduardo
   Montalvo-Gonzalez, Efigenia
TI Effect of Low-Fat Diets Enriched with Fruit Purees on the Biochemical
   Markers of Metabolic Syndrome Analogy Induced-Rats
SO INTERNATIONAL JOURNAL OF MORPHOLOGY
LA English
DT Article
DE Biochemical markers; Fruit purees; Hepatoprotective effect; Metabolic
   syndrome
ID OXIDATIVE STRESS; RISK-FACTORS; SUPPLEMENTATION; INFLAMMATION; ACID
AB Fruit purees can be added to diet as alternative sources of bioactive compounds for the prevention and/or improvement of the complications of metabolic syndrome. In this work we evaluated the effect of the intake of low-fat diets enriched with fruit purees (guava-strawberry, guava-blackberry, guava-soursop, guava-passion fruit) on the body weight and biochemical markers in metabolic syndrome analogy (MSA)-induced rats. The rats (n=6 for each treatment) were induced with a high fat diet and were injected with streptozotocin, one dose every week for 4 consecutive weeks after fasting overnight, then healthy rats were fed with standard diet and MS rats were fed with standard diet plus each of the fruit puree, for 4 weeks. As novel findings, the diet enriched with fruit purees was associated with a reduction in body weight (similar to 13-21 %) and a control in the metabolism of glucose by decreasing plasma glucose (similar to 59-63 %). Also, there was a reduction in the total cholesterol, triacylglycerols, low-density lipoproteins, and low enzymatic activities of alanine aminotransferase, alkaline phosphatase and gamma-glutamyl transferase, useful metabolites in the control of inflammatory processes in the liver. A notable improvement in the liver morphology was observed indicating that the treatments had a hepatoprotective effect. The diet enriched with guava-blackberry puree caused the best results on most biochemical markers of MS rats. Therefore, diets enriched with fruit purees can be an alternative for MS individuals for the control and improvement of the complications caused by this syndrome.
C1 [Mireya Morales-Avila, Ursula; Montalvo-Gonzalez, Efigenia] Inst Tecnol Tepic, Tecnol Nacl Mexico, Lab Integral Invest Alimentos, Tepic, Nayarit, Mexico.
   [Yahia, Elhadi M.] Univ Autonoma Queretaro, Fac Ciencias Nat, Queretaro, Mexico.
   [Montalvo-Gonzalez, Ruben; Mendeleev Becerra-Verdin, Eduardo] Univ Autonoma Nayarit, Lab Invest Clin Histol, Tepic, Nayarit, Mexico.
C3 Universidad Autonoma de Queretaro
RP Montalvo-González, E (corresponding author), Inst Tecnol Tepic, Tecnol Nacl Mexico, Lab Integral Invest Alimentos, Tepic, Nayarit, Mexico.
EM eduardo.becerra@uan.edu.mx; efimontalvo@gmail.com
RI Montalvo, Efigenia/AAR-7954-2020; yahia, elhadi/ABG-8101-2020
FU Tecnologico Nacional de Mexico [6173.17-P]; CONACYT-Mexico [211953]
FX We thank the Company Pures y Derivados de Nayarit for donating the raw
   materials. This work was supported by Tecnologico Nacional de Mexico
   (Grant no. 6173.17-P) and CONACYT-Mexico (Grant no. 211953).
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NR 25
TC 2
Z9 2
U1 3
U2 13
PU SOC CHILENA ANATOMIA
PI TEMUCO
PA CASILLA 54-D, TEMUCO, 00000, CHILE
SN 0717-9502
EI 0717-9367
J9 INT J MORPHOL
JI Int. J. Morphol.
PD FEB
PY 2020
VL 38
IS 1
BP 61
EP 68
PG 8
WC Anatomy & Morphology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Anatomy & Morphology
GA JP0RS
UT WOS:000497982000012
DA 2025-06-11
ER

PT J
AU Wang, LN
   Wang, M
   Liu, XJ
   Tian, JQ
   Zhang, L
   Li, YY
AF Wang, Lina
   Wang, Min
   Liu, Xiaojun
   Tian, Jiaqi
   Zhang, Ling
   Li, Yuanyuan
TI The association between uric acid to high-density cholesterol ratio and
   depression: A population-based cross-sectional study
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Uric acid to high-density cholesterol ratio; Depression; NHANES;
   Cross-sectional study
ID METABOLIC SYNDROME; IMMUNE-SYSTEM; LIPID-LEVELS; INFLAMMATION; ALCOHOL;
   DISEASE
AB Background: Depression is associated with inflammation, and the uric acid to HDL-C cholesterol ratio (UHR) has emerged as a potential marker of increased inflammation; however, the association between UHR and depression is unclear. Therefore, we aimed to explore this association in a sample from the general US population. Methods: We conducted a cross-sectional study of 11,444 participants >= 20 years of age from the 2009-2014 NHANES database. We conducted weighted multivariate logistic regression analyses and restricted cubic spline function (RCS) models exploring the association between UHR and risk of depression, as well as subgroup analyses and tests of interaction. Results: UHR was positively associated with depression, especially in participants who drank alcohol (interaction P < 0.05).The prevalence of depression increased by 4 % for each 1-unit increase in UHR (OR = 1.04, 95 % CI = 1.02, 1.07, P = 0.003). After dividing the UHR into quartiles compared with the lowest reference group for UHR, participants in the fourth quartile had a significantly increased risk of depression after full adjustment (OR = 1.36, 95 % CI = 1.03, 1.80, P = 0.033).There was a linear dose-response relationship between the UHR and the risk of depression (P for nonlinear = 0.744). Limitations: As this was a cross-sectional study, we could not determine a causal relationship between UHR and depression. Conclusion: The UHR is positively associated with an increased prevalence of depression among adults in the U.S.
C1 [Wang, Lina] Weifang Peoples Hosp, Dept Nursing, Weifang, Peoples R China.
   [Wang, Min] Shandong First Med Univ, East Branch, Intens Care Unit, Shandong Prov Hosp, Jinan, Peoples R China.
   [Li, Yuanyuan] Shandong First Med Univ, Shandong Prov Hosp, Dept Nursing, Jinan 250000, Peoples R China.
   [Liu, Xiaojun; Tian, Jiaqi; Zhang, Ling] Shandong Univ, Sch Nursing & Rehabil, Jinan 250000, Peoples R China.
C3 Shandong First Medical University & Shandong Academy of Medical
   Sciences; Shandong First Medical University & Shandong Academy of
   Medical Sciences; Shandong University
RP Li, YY (corresponding author), Shandong First Med Univ, Shandong Prov Hosp, Dept Nursing, Jinan 250000, Peoples R China.
EM yuanyuanquan7@126.com
RI wang, lin/HZK-4145-2023
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PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD JUN 15
PY 2025
VL 379
BP 502
EP 509
DI 10.1016/j.jad.2025.03.023
EA MAR 2025
PG 8
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA 0KZ0T
UT WOS:001449855900001
PM 40054537
DA 2025-06-11
ER

PT J
AU Kirpekar, VC
   Faye, AD
   Bhave, SH
   Tadke, R
   Gawande, S
AF Kirpekar, Vivek C.
   Faye, Abhijeet D.
   Bhave, Sudhir H.
   Tadke, Rahul
   Gawande, Sushi
TI Lurasidone-induced anemia: Is there a need for hematological monitoring?
SO INDIAN JOURNAL OF PHARMACOLOGY
LA English
DT Article
DE Anemia; blood monitoring; lurasidone; reversible
AB Lurasidone is a newer drug used for treating schizophrenia and depression in bipolar disorder. Although comparatively safe, some side effects can occur with its use such as akathisia, extrapyramidal reaction, metabolic syndrome, and hyperprolactinemia. Blood dyscrasia with lurasidone is rarely reported in the literature except for few case reports. We present two cases of schizophrenia, treated with lurasidone developing anemia after variable period of treatment and reverting after stopping lurasidone. These cases emphasize the timely monitoring of blood parameters for prevention or early detection of anemia in patients treated with lurasidone.
C1 [Kirpekar, Vivek C.; Bhave, Sudhir H.; Tadke, Rahul; Gawande, Sushi] NKP Salve Inst Med Sci, Dept Psychiat, Nagpur, Maharashtra, India.
   [Kirpekar, Vivek C.; Faye, Abhijeet D.; Bhave, Sudhir H.; Tadke, Rahul; Gawande, Sushi] Late Mangeshkar Hosp, Digdoh Hills,Hingna Rd, Nagpur 440019, Maharashtra, India.
RP Faye, AD (corresponding author), Late Mangeshkar Hosp, Digdoh Hills,Hingna Rd, Nagpur 440019, Maharashtra, India.; Faye, AD (corresponding author), NKP Salve Inst Med Sci, Dept Psychiat OPD 10, 2nd Floor,OPD Bldg, Nagpur 440019, Maharashtra, India.
EM abhijeetfaye12@gmail.com
RI kirpekar, vivek/AAI-1180-2019
CR Bawa Radhika, 2015, Innov Clin Neurosci, V12, P21
   Cruz Martin P, 2011, P T, V36, P489
   Greene EM, PHARMACOTHERAPY PATH
   Pompili M, 2018, EXPERT OPIN DRUG SAF, V17, P197, DOI 10.1080/14740338.2017.1379989
   Rafi M, 2018, INDIAN J PSYCHOL MED, V40, P191, DOI 10.4103/IJPSYM.IJPSYM_374_17
   Sood S, 2017, CLIN PSYCHOPHARM NEU, V15, P413, DOI 10.9758/cpn.2017.15.4.413
   Sunovion Pharmaceuticals, LAT 18 5MG 37MG 74MG
   Sunovion Pharmaceuticals Inc, 2013, LAT LAUR HYDR PACK I
NR 8
TC 5
Z9 5
U1 0
U2 3
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, Maharashtra, INDIA
SN 0253-7613
EI 1998-3751
J9 INDIAN J PHARMACOL
JI Indian J. Pharmacol.
PD JUL-AUG
PY 2019
VL 51
IS 4
BP 276
EP 278
DI 10.4103/ijp.IJP_434_18
PG 3
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA IY4OP
UT WOS:000486373200008
PM 31571715
OA Green Published
DA 2025-06-11
ER

PT J
AU Leung, JWC
   Ghosal, G
   Wang, WQ
   Shen, X
   Wang, JD
   Li, L
   Chen, JJ
AF Leung, Justin Wai-Chung
   Ghosal, Gargi
   Wang, Wenqi
   Shen, Xi
   Wang, Jiadong
   Li, Lei
   Chen, Junjie
TI Alpha Thalassemia/Mental Retardation Syndrome X-linked Gene Product ATRX
   Is Required for Proper Replication Restart and Cellular Resistance to
   Replication Stress
SO JOURNAL OF BIOLOGICAL CHEMISTRY
LA English
DT Article
ID ONCOGENE-INDUCED SENESCENCE; DNA-DAMAGE; MENTAL-RETARDATION; GENOMIC
   INTEGRITY; HISTONE CHAPERONE; S PHASE; PROTEIN; MUTATIONS; CELLS;
   RECOMBINATION
AB Alpha thalassemia/mental retardation syndrome X-linked (ATRX) is a member of the SWI/SNF protein family of DNA-dependent ATPases. It functions as a chromatin remodeler and is classified as an SNF2-like helicase. Here, we showed somatic knock-out of ATRX displayed perturbed S-phase progression as well as hypersensitivity to replication stress. ATRX is recruited to sites of DNA damage, required for efficient checkpoint activation and faithful replication restart. In addition, we identified ATRX as a binding partner of MRE11-RAD50-NBS1 (MRN) complex. Together, these results suggest a non-canonical function of ATRX in guarding genomic stability.
C1 [Leung, Justin Wai-Chung; Ghosal, Gargi; Wang, Wenqi; Shen, Xi; Wang, Jiadong; Li, Lei; Chen, Junjie] Univ Texas MD Anderson Canc Ctr, Dept Expt Radiat Oncol, Houston, TX 77030 USA.
C3 University of Texas System; UTMD Anderson Cancer Center
RP Chen, JJ (corresponding author), Univ Texas MD Anderson Canc Ctr, Dept Expt Radiat Oncol, Unit 66, 1515 Holcombe Blvd,Room Y3-6006, Houston, TX 77030 USA.
EM jchen8@mdanderson.org
RI chen, junjie/LEB-0600-2024
OI Leung, Justin Wai Chung/0000-0003-4601-390X; Wang,
   Wenqi/0000-0003-4053-5088; Ghosal, Gargi/0000-0001-8399-5354
FU National Institutes of Health [CA089239, CA092312]; Dept. of Defense
   [W81XWH-05-1-0470]
FX This work was supported in part by Grants CA089239 and CA092312 (to J.
   C.) from the National Institutes of Health.Recipient of an Era of Hope
   Scholar award from the Dept. of Defense (W81XWH-05-1-0470) and a member
   of the M. D. Anderson Cancer Center (CA016672).
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NR 41
TC 79
Z9 101
U1 0
U2 11
PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3996 USA
EI 1083-351X
J9 J BIOL CHEM
JI J. Biol. Chem.
PD MAR 1
PY 2013
VL 288
IS 9
BP 6342
EP 6350
DI 10.1074/jbc.M112.411603
PG 9
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 102CJ
UT WOS:000315820700029
PM 23329831
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Shen, YH
   Zhang, L
   Gan, YH
   Wang, XW
   Wang, J
   LeMaire, SA
   Coselli, JS
   Wang, XL
AF Shen, YH
   Zhang, L
   Gan, YH
   Wang, XW
   Wang, J
   LeMaire, SA
   Coselli, JS
   Wang, XL
TI Up-regulation of PTEN (phosphatase and tensin homolog deleted on
   chromosome ten) mediates p38 MAPK stress signal-induced inhibition of
   insulin signaling - A cross-talk between stress signaling and insulin
   signaling in resistin-treated human endothelial cells
SO JOURNAL OF BIOLOGICAL CHEMISTRY
LA English
DT Article
ID ACTIVATED PROTEIN-KINASES; INFLAMMATORY CYTOKINES; METABOLIC SYNDROME;
   SKELETAL-MUSCLE; INDUCED PHOSPHORYLATION; DEPENDENT DILATATION; RECEPTOR
   SUBSTRATE-1; LEPTIN LEVELS; IN-VIVO; GLUCOSE
AB The key feature of metabolic syndrome, a cluster of metabolic and cardiovascular disorders, is systemic insulin resistance, which is associated with dysregulated endothelial nitric-oxide synthase ( eNOS). Stress signaling induced by inflammation can inhibit insulin signaling. However, molecular mechanisms for the cross-talk between stress signaling and insulin resistance are only partially understood. Resistin, an adipokine/ cytokine, is involved in inflammatory processes that could lead to insulin resistance status and vascular diseases. In the current study, we observed that resistin inhibited insulin signaling and eNOS activation in endothelial cells. Up-regulation of PTEN ( phosphatase and tensin homolog deleted on chromosome ten) expression by resistin may mediate the inhibitory effects. Activated stress signaling p38 MAPK, but not JNK, is involved in PTEN up-regulation. We further found that p38 target transcriptional factor activating transcription factor-2 (ATF-2) bound to ATF sites in the PTEN promoter. The phosphorylation/ activation of ATF-2 and its binding to PTEN promoter were increased by resistin treatment. In summary, up-regulation of PTEN is involved in the inhibitory effects of resistin on insulin signaling and eNOS activation in endothelial cells. Resistin induces PTEN expression by activating stress signaling p38 pathway, which may activate target transcription factor ATF-2, which in turn induces PTEN expression. Our findings suggest that resistin-mediated inhibition of insulin signaling and eNOS activation may contribute to cardiovascular diseases.
C1 Baylor Coll Med, Div Cardiothorac Surg, Michael E DeBakey Dept Surg, Houston, TX 77030 USA.
   St Lukes Episcopal Hosp, Texas Heart Inst, Sect Adult Cardiac Surg, Houston, TX USA.
C3 Baylor College of Medicine; Texas Heart Institute; Saint Lukes Episcopal
   Hospital
RP Baylor Coll Med, Div Cardiothorac Surg, Michael E DeBakey Dept Surg, NAB 2010,1 Baylor Plaza, Houston, TX 77030 USA.
EM hyshen@bcm.tmc.edu; xlwang@bcm.tmc.edu
RI shen, ying/HHS-5635-2022
OI LeMaire, Scott/0000-0002-8736-4266
FU NHLBI NIH HHS [R01-HL071608, R01-HL066053] Funding Source: Medline
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NR 77
TC 122
Z9 162
U1 0
U2 7
PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
PI ROCKVILLE
PA 11200 ROCKVILLE PIKE, SUITE 302, ROCKVILLE, MD, UNITED STATES
SN 0021-9258
EI 1083-351X
J9 J BIOL CHEM
JI J. Biol. Chem.
PD MAR 24
PY 2006
VL 281
IS 12
BP 7727
EP 7736
DI 10.1074/jbc.M511105200
PG 10
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 022BZ
UT WOS:000236031000005
PM 16418168
OA hybrid
DA 2025-06-11
ER

PT J
AU Molendi-Coste, O
   Legry, V
   Leclercq, IA
AF Molendi-Coste, O.
   Legry, V.
   Leclercq, I. A.
TI Dietary lipids and NAFLD: suggestions for improved nutrition
SO ACTA GASTRO-ENTEROLOGICA BELGICA
LA English
DT Review
DE NAFLD; dietary recommendations; saturated fatty acids; monounsaturated
   fatty fatty acids; poyunsaturated fatty acid
ID FATTY LIVER-DISEASE; METABOLIC SYNDROME; INSULIN-RESISTANCE; HEPATIC
   STEATOSIS; NONALCOHOLIC STEATOHEPATITIS; MONOUNSATURATED FAT; DESATURASE
   ACTIVITY; LINOLEIC-ACID; INFLAMMATION; OBESITY
AB Non-alcoholic fatty liver disease (NAFLD) ranges from steatosis and hepatic insulin resistance to non-alcoholic steatohepatitis (NASH), advanced fibrosis and cirrhosis. NAFLD is now considered as the hepatic manifestation of the metabolic syndrome, and both are triggered by mechanisms including inflammation, lipid overload and oxidative stress in adipose tissue and liver. Despite accumulation of numerous data on NAFLD physiopathology, therapeutic modulation of the pathways involved appear insufficiently efficient or associated with serious adverse effects. The increased prevalence of NAFLD and metabolic syndrome during the last decades was associated with deep modifications of dietary habits, especially increased fat intakes. Recent literature provides clues of increased saturated (SFA) and n-6 polyunsaturated fatty acids (PUFA) as well as reduced n-3 PUFA in the diet of NAFLD and NASH patients. Indeed, strong data support the detrimental role of high SFA and n-6/n-3 ratio as well as low monounsaturated fatty acids (MUFA) and n-3 PUFA on metabolic parameters, which are ameliorated by administration of n-3 PUFA and MUFA. Despite governments and health associations having revised their recommendations for n-3 PUFA intakes upward during the last decade, those are still inferior to levels proved of therapeutic efficiency and are still not reached in the general population. This short review discusses these issues and provides consequent pragmatic suggestions for enhanced dietary measures for prevention of NAFLD and metabolic syndrome in the general population. (Acta gastroenterol belg., 2010, 73, 431-436)
C1 [Molendi-Coste, O.; Legry, V.; Leclercq, I. A.] Catholic Univ Louvain, Inst Rech Expt & Clin, Lab Hepatogastroenterol, B-1200 Brussels, Belgium.
C3 Universite Catholique Louvain
RP Leclercq, IA (corresponding author), Catholic Univ Louvain, Inst Rech Expt & Clin, Lab Hepatogastroenterol, GAEN 53-79,Ave Mounier 53, B-1200 Brussels, Belgium.
EM isabelle.leclercq@uclouvain.be
RI Molendi-Coste, Olivier/HKW-3196-2023
OI Molendi-Coste, Olivier/0000-0002-0498-9456
FU FRS-FNRS [3.4578.07, M.IS : F.45.08.08]; la Direction de la Recherche
   Scientifique de la Communaute Francaise de Belgique (ARC) [05/10-328];
   University FSR
FX This work was supported by FRS-FNRS grants (N<SUP>o</SUP>3.4578.07 and
   M.IS : F.45.08.08), la Direction de la Recherche Scientifique de la
   Communaute Francaise de Belgique (ARC grant, 05/10-328), University FSR
   grants to I.L.; O.M.C. and I.L. are FRS-FNRS post-doctoral researcher
   and reseach associated, respectively.
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NR 74
TC 15
Z9 16
U1 0
U2 9
PU UNIV CATHOLIQUE LOUVAIN-UCL
PI BRUSSELS
PA CLIN UNIV SAINT LUC, AVE HIPPOCRATE 10, BRUSSELS, B-1200, BELGIUM
SN 1784-3227
J9 ACTA GASTRO-ENT BELG
JI Acta Gastro-Enterol. Belg.
PD OCT-DEC
PY 2010
VL 73
IS 4
BP 431
EP 436
PG 6
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 716WZ
UT WOS:000287005500001
PM 21299150
DA 2025-06-11
ER

PT J
AU Jenzsch, A
   Eick, S
   Rassoul, F
   Purschwitz, R
   Jentsch, H
AF Jenzsch, Axel
   Eick, Sigrun
   Rassoul, Fausi
   Purschwitz, Regina
   Jentsch, Holger
TI Nutritional intervention in patients with periodontal disease: clinical,
   immunological and microbiological variables during 12 months
SO BRITISH JOURNAL OF NUTRITION
LA English
DT Article
DE Periodontitis; Diet; Metabolic syndrome
ID GINGIVAL CREVICULAR FLUID; GLUTATHIONE-PEROXIDASE; LIPID-PEROXIDATION;
   OXIDATIVE STRESS; CYTOKINE BIOLOGY; FATTY-ACIDS; INFLAMMATION; ELASTASE;
   HEALTH; MYELOPEROXIDASE
AB The role of nutrition in onset. progression and treatment of periodontitis has not been thoroughly evaluated. In the present prospective clinical study, we investigated the influence of a nutritional intervention on changes in clinical, microbiological and immunological periodontal variables during a period of 12 months in patients with the metabolic syndrome and chronic periodontitis. Twenty female subjects with the metabolic syndrome and mild to moderate chronic periodontitis participated in a guided nutritional intervention programme. Examinations were assessed before, and at 2 weeks, 3, 6 and 12 months after intervention. Clinical measurements included probing depth, Loe and Silness gingival index and Quigley-Hein plaque index. In gingival crevicular fluid, periodontopathogens, levels of IL-1 beta and IL-6 as well as the activity of granulocyte elastase were determined. In stimulated saliva, antioxidative and oxidative variables were measured. After 12 months the following significant changes could be observed: reduction of clinical probing depth (2.40 v. 2.20mm; P<0.001), reduction of gingival inflammation (gingival index 1.13 v. 0.9; P<0.001), reduced concentrations of IL-1 beta (4.63 v. 1.10pg/ml per sited P<0.001) as well as IL-6 (1.85 v. 0.34pg/ml per site; P=0.022) in gingival crevicular fluid. Bacterial counts in gingival crevicular fluid as well as oxidative and antioxidative variables in saliva showed no significant changes. Only salivary catalase showed a tendency to lower values. These findings indicate that in patients with the metabolic syndrome whole-some nutrition might reduce inflammatory variables of periodontal disease and promote periodontal health.
C1 [Jenzsch, Axel; Purschwitz, Regina; Jentsch, Holger] Univ Leipzig, Dept Conservat Dent & Periodontol, D-04103 Leipzig, Germany.
   [Eick, Sigrun] Univ Jena, Inst Med Microbiol, Dept Oral Microbiol, Jena, Germany.
   [Rassoul, Fausi] Univ Leipzig, Inst Lab Med Clin Chem & Mol Diagnost, D-04103 Leipzig, Germany.
C3 Leipzig University; Friedrich Schiller University of Jena; Leipzig
   University
RP Jenzsch, A (corresponding author), Univ Leipzig, Dept Conservat Dent & Periodontol, Liebigstr 57, D-04103 Leipzig, Germany.
EM axel.jenzsch@medizin.uni-leipzig.de
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NR 43
TC 54
Z9 55
U1 1
U2 7
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1145
EI 1475-2662
J9 BRIT J NUTR
JI Br. J. Nutr.
PD MAR 28
PY 2009
VL 101
IS 6
BP 879
EP 885
DI 10.1017/S0007114508047776
PG 7
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 428OM
UT WOS:000264858200016
PM 18713481
OA Bronze
DA 2025-06-11
ER

PT J
AU Osama, H
   Hamed, EO
   Mahmoud, MA
   Abdelrahim, MEA
AF Osama, Hasnaa
   Hamed, Ehdaa O.
   Mahmoud, Muhammed A.
   Abdelrahim, Mohamed E. A.
TI The Effect of Hesperidin and Diosmin Individually or in Combination on
   Metabolic Profile and Neuropathy among Diabetic Patients with Metabolic
   Syndrome: A Randomized Controlled Trial
SO JOURNAL OF DIETARY SUPPLEMENTS
LA English
DT Article
DE hesperidin; diosmin; metabolic syndrome; diabetic neuropathy; citrus
   flavonoids; integrative medicine; phytotherapy
ID OXIDATIVE STRESS; DENSITY-LIPOPROTEIN; BLOOD-PRESSURE; MODEL
AB Current evidence supports the association of metabolic syndrome (MetS) with neuropathy. Limited data are available on proper strategies to control metabolic disorders and neuropathy among patients with type2 diabetes mellitus (T2DM). We aimed to determine hesperidin and diosmin efficacy individually and in combination among T2DM patients with neuropathy and meet MetS criteria. In this parallel-group designed trial, 129 T2DM patients with MetS and neuropathy were recruited and randomized to receive their oral hypoglycemics with either hesperidin (1g/day), or diosmin (1g/day), or combination of both or oral hypoglycemics without intervention for 12 weeks. Diabetic neuropathy was evaluated using Michigan Neuropathy Screening Instrument (MNSI) at baseline and after trial. Anthropometric parameters, blood glucose and lipid profile were also assessed before and after the intervention using paired student t-test within groups. The trial is registered at clinicaltrials.gov as NCT05243238. By completion of the trial duration, both hesperidin and diosmin groups showed significant reduction in blood glucose, triglycerides (TGs) and low density lipoprotein (LDL) from baseline (p<0.05). However, the magnitude of improvement in metabolic components significantly increased with hesperidin and diosmin combination. Although MNSI scores improved significantly in both groups, the reduction was more significant with the combination of hesperidin and diosmin. Moreover, the change in MNSI score was significantly correlated with the improvement in metabolic profile components including LDL, TGs and fasting blood glucose. Oral supplementation of hesperidin and diosmin was associated with improvement in metabolic syndrome and diabetic neuropathy and the combination of both was superior in efficacy.
C1 [Osama, Hasnaa; Abdelrahim, Mohamed E. A.] Beni Suef Univ, Fac Pharm, Clin Pharm Dept, Bani Suwayf, Egypt.
   [Hamed, Ehdaa O.] Agr Res Ctr ARC, Anim Hlth Res Inst AHRI, Dept Chem Toxicol & Nutr Deficiency, Toxicol Unit,El Fayoum Governorate Lab, Cairo, Egypt.
   [Mahmoud, Muhammed A.] Natl Org Drug Control & Res, Giza, Egypt.
C3 Egyptian Knowledge Bank (EKB); Beni Suef University; Animal Health
   Research Institute (AHRI); National Organization for Drug Control &
   Research (NODCAR)
RP Osama, H (corresponding author), Beni Suef Univ, Fac Pharm, Clin Pharm Dept, Bani Suwayf, Egypt.
EM hasnaa_osama2010@yahoo.com
RI Osama, Hassna/ACV-9217-2022; Abdelrahim, Mohamed/AAJ-7075-2020
OI abdelrahim, mohamed/0000-0003-0227-8404; osama,
   hasnaa/0000-0003-2990-5981
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NR 45
TC 15
Z9 16
U1 4
U2 10
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1939-0211
EI 1939-022X
J9 J DIET SUPPL
JI J. Diet. Suppl.
PD SEP 3
PY 2023
VL 20
IS 5
BP 749
EP 762
DI 10.1080/19390211.2022.2107138
EA JUL 2022
PG 14
WC Nutrition & Dietetics; Pharmacology & Pharmacy
WE Emerging Sources Citation Index (ESCI)
SC Nutrition & Dietetics; Pharmacology & Pharmacy
GA O0FC1
UT WOS:000838601600001
PM 35946912
DA 2025-06-11
ER

PT J
AU Rosés, C
   Garcia-Ibañez, P
   Agudelo, A
   Viadel, B
   Tomás-Cobos, L
   Gallego, E
   Carvajal, M
   Milagro, FI
   Barceló, A
AF Roses, Carles
   Garcia-Ibanez, Paula
   Agudelo, Agatha
   Viadel, Blanca
   Tomas-Cobos, Lidia
   Gallego, Elisa
   Carvajal, Micaela
   Milagro, Fermin I.
   Barcelo, Anna
TI Effects of Glucosinolate-Enriched Red Radish (Raphanus sativus) on In
   Vitro Models of Intestinal Microbiota and Metabolic Syndrome-Related
   Functionalities
SO ACS OMEGA
LA English
DT Article
ID SP-NOV.; GUT MICROBIOTA; GEN.-NOV.; NITRIC-OXIDE;
   BIFIDOBACTERIUM-ANIMALIS; OXIDATIVE STRESS; HUMAN FECES; BUTYRATE;
   BACTERIUM; BROCCOLI
AB The gut microbiotaprofile is determined by diet composition, andtherefore this interaction is crucial for promoting specific bacterialgrowth and enhancing the health status. Red radish (Raphanus sativus L.) contains severalsecondary plant metabolites that can exert a protective effect onhuman health. Recent studies have shown that radish leaves have ahigher content of major nutrients, minerals, and fiber than roots,and they have garnered attention as a healthy food or supplement.Therefore, the consumption of the whole plant should be considered,as its nutritional value may be of greater interest. The aim of thiswork is to evaluate the effects of glucosinolate (GSL)-enriched radishwith elicitors on the intestinal microbiota and metabolic syndrome-relatedfunctionalities by using an in vitro dynamic gastrointestinalsystem and several cellular models developed to study the GSL impacton different health indicators such as blood pressure, cholesterolmetabolism, insulin resistance, adipogenesis, and reactive oxygenspecies (ROS). The treatment with red radish had an influence on short-chainfatty acids (SCFA) production, especially on acetic and propionicacid and many butyrate-producing bacteria, suggesting that consumptionof the entire red radish plant (leaves and roots) could modify thehuman gut microbiota profile toward a healthier one. The evaluationof the metabolic syndrome-related functionalities showed a significantdecrease in the gene expression of endothelin, interleukin IL-6, andcholesterol transporter-associated biomarkers (ABCA1 and ABCG5), suggestingan improvement of three risk factors associated with metabolic syndrome.The results support the idea that the use of elicitors on red radishcrops and its further consumption (the entire plant) may contributeto improving the general health status and gut microbiota profile.
C1 [Roses, Carles; Barcelo, Anna] Univ Autonoma Barcelona, Serv Genom, Bellaterra 08193, Cerdanyola Del, Spain.
   [Garcia-Ibanez, Paula; Carvajal, Micaela] CEBAS CSIC, Ctr Edafol & Biol Aplicada Segura, Aquaporins Grp, E-30100 Murcia, Spain.
   [Garcia-Ibanez, Paula; Carvajal, Micaela] CEBAS CSIC, Ctr Edafol & Biol Aplicada Segura, Dept Food Sci Technol, Phytochem & Hlth Foods Lab, E-30100 Murcia, Spain.
   [Agudelo, Agatha] Sakata Seed Iber SL, Valencia 46021, Spain.
   [Agudelo, Agatha] Univ Politecn Valencia, UPV, Valencia 46022, Spain.
   [Viadel, Blanca; Tomas-Cobos, Lidia; Gallego, Elisa] AINIA, Technol Ctr, Paterna 46980, Valenca, Spain.
   [Milagro, Fermin I.] Univ Navarra, Ctr Nutr Res, Dept Nutr Food Sci & Physiol, Pamplona 31008, Spain.
   [Milagro, Fermin I.] Navarra Inst Hlth Res IdISNA, Pamplona 31008, Spain.
   [Milagro, Fermin I.] Inst Salud Carlos III, Ctr Investigac Biomed Red Fisiopatol Obes & Nutr C, Madrid, Spain.
C3 Autonomous University of Barcelona; Consejo Superior de Investigaciones
   Cientificas (CSIC); CSIC - Centro de Edafologia y Biologia Aplicada del
   Segura (CEBAS); Consejo Superior de Investigaciones Cientificas (CSIC);
   CSIC - Centro de Edafologia y Biologia Aplicada del Segura (CEBAS);
   Universitat Politecnica de Valencia; University of Navarra; University
   of Navarra; Instituto de Salud Carlos III
RP Milagro, FI (corresponding author), Univ Navarra, Ctr Nutr Res, Dept Nutr Food Sci & Physiol, Pamplona 31008, Spain.; Milagro, FI (corresponding author), Navarra Inst Hlth Res IdISNA, Pamplona 31008, Spain.; Milagro, FI (corresponding author), Inst Salud Carlos III, Ctr Investigac Biomed Red Fisiopatol Obes & Nutr C, Madrid, Spain.
EM fmilagro@unav.es
RI Milagro, Fermin/F-2315-2015; Carvajal, Micaela/H-8920-2015
OI Carvajal, Micaela/0000-0001-7321-4956; Roses Pol,
   Carles/0000-0003-0060-9353
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NR 108
TC 5
Z9 5
U1 0
U2 6
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 2470-1343
J9 ACS OMEGA
JI ACS Omega
PD JUN 22
PY 2023
VL 8
IS 26
BP 23373
EP 23388
DI 10.1021/acsomega.2c08128
EA JUN 2023
PG 16
WC Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry
GA K8IT1
UT WOS:001016031600001
PM 37426251
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Sachdev, PS
   Brodaty, H
   Reppermund, S
   Kochan, NA
   Trollor, JN
   Draper, B
   Slavin, MJ
   Crawford, J
   Kang, K
   Broe, GA
   Mather, KA
   Lux, O
AF Sachdev, Perminder S.
   Brodaty, Henry
   Reppermund, Simone
   Kochan, Nicole A.
   Trollor, Julian N.
   Draper, Brian
   Slavin, Melissa J.
   Crawford, John
   Kang, Kristan
   Broe, G. Anthony
   Mather, Karen A.
   Lux, Ora
CA Memory Ageing Study Team
TI The Sydney Memory and Ageing Study (MAS): methodology and baseline
   medical and neuropsychiatric characteristics of an elderly
   epidemiological non-demented cohort of Australians aged 70-90 years
SO INTERNATIONAL PSYCHOGERIATRICS
LA English
DT Article
DE mild cognitive impairment; cognitive function; dementia; cognitive
   decline; magnetic resonance imaging (MRI); fMRI; metabolic syndrome;
   inflammatory markers; balance; falls; depression; anxiety; genetics;
   proteomics
ID MILD COGNITIVE IMPAIRMENT; WHITE-MATTER HYPERINTENSITIES;
   MINI-MENTAL-STATE; APOLIPOPROTEIN-E; NORMATIVE DATA; ALZHEIMER-DISEASE;
   APOE GENOTYPE; LIFE-STYLE; PREVALENCE; HEALTH
AB Background: The Sydney Memory and Ageing Study (Sydney MAS) was initiated in 2005 to examine the clinical characteristics and prevalence of mild cognitive impairment (MCI) and related syndromes, and to determine the rate of change in cognitive function over time.
   Methods: Non-demented community-dwelling individuals (N = 1037) aged 70-90 were recruited from two areas of Sydney, following a random approach to 8914 individuals on the electoral roll. They underwent detailed neuropsychiatric and medical assessments and donated a blood sample for clinical chemistry, proteomics and genomics. A knowledgeable informant was also interviewed. Structural MRI scans were performed on 554 individuals, and subgroups participated in studies of falls and balance, metabolic and inflammatory markers, functional MRI and prospective memory. The cohort is to be followed up with brief telephone reviews annually, and detailed assessments biannually.
   Results: This is a generally well-functioning cohort mostly living in private homes and rating their health as being better than average, although vascular risk factors are common. Most (95.5%) participants or their informants identified a cognitive difficulty, and 43.5% had impairment on at least one neuropsychological test. MCI criteria were met by 34.8%; with 19.3% qualifying for amnestic MCI, whereas 15.5% had non-amnestic MCI; 1.6% had impairment on neuropsychological test performance but no subjective complaints; and 5.8% could not be classified. The rate of MCI was 30.9% in the youngest (70-75) and 39.1% in the oldest (85-90) age bands. Rates of depression and anxiety were 7.1% and 6.9% respectively.
   Conclusions: Cognitive complaints are common in the elderly, and nearly one in three meet criteria for MCI. Longitudinal follow-up of this cohort will delineate the progression of complaints and objective cognitive impairment, and the determinants of such change.
C1 [Sachdev, Perminder S.] Prince Wales Hosp, UNSW Sch Psychiat, NPI, Euroa Ctr,Neuropsychiat Inst, Randwick, NSW 2031, Australia.
   [Sachdev, Perminder S.; Brodaty, Henry; Reppermund, Simone; Kochan, Nicole A.; Trollor, Julian N.; Draper, Brian; Slavin, Melissa J.; Crawford, John; Kang, Kristan; Mather, Karen A.; Lux, Ora; Memory Ageing Study Team] Univ New S Wales, Brain & Ageing Res Program, Sch Psychiat, Fac Med, Sydney, NSW, Australia.
   [Sachdev, Perminder S.; Brodaty, Henry; Draper, Brian; Broe, G. Anthony] Univ New S Wales, Sch Psychiat, Primary Dementia Collaborat Res Ctr, Fac Med, Sydney, NSW, Australia.
   [Brodaty, Henry; Draper, Brian] Prince Wales Hosp, Acad Dept Old Age Psychiat, Randwick, NSW 2031, Australia.
   [Broe, G. Anthony] Prince Wales Med Res Inst, Randwick, NSW, Australia.
   [Broe, G. Anthony] Prince Wales Hosp, Ageing Res Ctr, Randwick, NSW 2031, Australia.
   [Lux, Ora] Prince Wales Hosp, SE Area Lab Serv, Randwick, NSW 2031, Australia.
C3 University of New South Wales Sydney; Prince of Wales Hospital (POWH);
   University of New South Wales Sydney; University of New South Wales
   Sydney; University of New South Wales Sydney; Prince of Wales Hospital
   (POWH); Neuroscience Research Australia; University of New South Wales
   Sydney; Prince of Wales Hospital (POWH); University of New South Wales
   Sydney; Prince of Wales Hospital (POWH)
RP Sachdev, PS (corresponding author), Prince Wales Hosp, UNSW Sch Psychiat, NPI, Euroa Ctr,Neuropsychiat Inst, Barker St, Randwick, NSW 2031, Australia.
EM sachdev@unsw.edu.au
RI Reppermund, Simone/C-9329-2009; Karen, Mather/O-9795-2016; Brodaty,
   Henry/E-2753-2010; Sachdev, Perminder/ABC-1137-2020; Slavin,
   Melissa/F-7509-2010; Sachdev, Perminder/H-3968-2015
OI Trollor, Julian/0000-0002-7685-2977; Mather, Karen
   Anne/0000-0003-4143-8941; Kang, Kristan/0000-0002-2057-1033; Sachdev,
   Perminder/0000-0002-9595-3220; Brodaty, Henry/0000-0001-9487-6617
FU National Health and Medical Research Council of Australia [401184,
   350833]
FX DNA samples were extracted by Genetic Repositories Australia, an
   enabling facility, which is supported by a National Health and Medical
   Research Council of Australia Grant, 401184. The APOE genotyping was
   performed by Arezoo Assareh and Karen Mather under the supervision of
   Professor Peter Schofield and John Kwok at the Prince of Wales Medical
   Research Institute, Sydney, Australia. Blood samples were collected by
   South Eastern Area Laboratory Service. Angie Russell assisted with the
   preparation of the paper. We thank the participants for their
   enthusiastic support. This study was supported by a National Health and
   Medical Research Council of Australia Program Grant (ID 350833).
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NR 82
TC 273
Z9 273
U1 1
U2 8
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
SN 1041-6102
EI 1741-203X
J9 INT PSYCHOGERIATR
JI Int. Psychogeriatr.
PD DEC
PY 2010
VL 22
IS 8
BP 1248
EP 1264
DI 10.1017/S1041610210001067
PG 17
WC Psychology, Clinical; Geriatrics & Gerontology; Gerontology; Psychiatry;
   Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Geriatrics & Gerontology; Psychiatry
GA 678AO
UT WOS:000284039700008
PM 20637138
OA hybrid
DA 2025-06-11
ER

PT J
AU Seo, MW
   Gann, J
   Lee, JM
   Heffernan, KS
   Kim, JY
   Jung, HC
AF Seo, Myong-Won
   Gann, Joshua
   Lee, Jung-Min
   Heffernan, Kevin S. S.
   Kim, Joon Young
   Jung, Hyun Chul
TI Potential impact of metabolic syndrome on cognitive function in US
   firefighters
SO FRONTIERS IN PUBLIC HEALTH
LA English
DT Article
DE firefighter health; occupational risk; cardiometabolic disease risk;
   cognitive health; line-of-duty deaths
ID INSULIN-RESISTANCE; CARDIORESPIRATORY FITNESS; HEALTH; PREVALENCE;
   PREDICTORS; OBESITY; RISKS; AGE
AB ObjectivesAmong US firefighters, sudden cardiac arrest and psychological stress (i.e., PTSD) are the leading cause of on-duty death. Metabolic syndrome (MetSyn) may influence both cardiometabolic and cognitive health. Here, we examined differences in cardiometabolic disease risk factors, cognitive function, and physical fitness in US firefighters with vs. without MetSyn. Materials and methodsOne hundred fourteen male firefighters, aged 20 to 60 years, participated in the study. US firefighters with MetSyn vs. non-MetSyn were divided by AHA/NHLBI criteria. Of them, we performed a paired-match analysis with respect to the age and BMI of firefighters with (n = 18) vs. without MetSyn (n = 18). The cardiometabolic disease risk factors included blood pressure, fasting glucose, blood lipid profiles [HDL-C, triglyceride (TG)], and surrogate markers of insulin resistance [TG/HDL-C, TG glucose index (TyG)]. The cognitive test included a psychomotor vigilance task as a measure of reaction time and a delayed-match-to-sample task (DMS) as a measure of memory, using the computer-based Psychological Experiment Building Language Version 2.0 program. The differences between MetSyn and non-MetSyn groups in US firefighters were analyzed using an independent t-test adjusted for age and BMI. In addition, Spearman correlation and stepwise multiple regression were conducted. ResultsUS firefighters with MetSyn exhibited severe insulin resistance estimated by TG/HDL-C and TyG (Cohen's d > 0.8, all p < 0.01) compared with their age- and BMI-matched counterparts without MetSyn. In addition, US firefighters with MetSyn exhibited higher DMS total time and reaction time compared with non-MetSyn (Cohen's d > 0.8, all p < 0.01). In stepwise linear regression, HDL-C predicted DMS total time (beta = - 0.440, R-2 = 0.194, p < 0.05), and TyG (beta = 0.432, R-2 = 0.186, p < 0.05) predicted DMS reaction time. ConclusionUS firefighters with vs. without MetSyn were predisposed to metabolic risk factors, surrogate markers of insulin resistance, and cognitive function, even when matched for age and BMI, and there was a negative association between metabolic characteristics and cognitive function in US firefighters. The findings of this study suggest that the prevention of MetSyn may be beneficial to supporting firefighters' safety and occupational performance.
C1 [Seo, Myong-Won; Heffernan, Kevin S. S.; Kim, Joon Young] Syracuse Univ, David B Falk Coll Sports & Human Dynam, Dept Exercise Sci, Syracuse, NY USA.
   [Gann, Joshua] Univ Louisiana Monroe, Sch Allied Hlth, Dept Kinesiol, Monroe, LA USA.
   [Lee, Jung-Min; Jung, Hyun Chul] Kyung Hee Univ, Sports Sci Res Ctr, Yongin, South Korea.
   [Lee, Jung-Min] Kyung Hee Univ, Coll Phys Educ, Dept Phys Educ, Yongin, South Korea.
   [Jung, Hyun Chul] Kyung Hee Univ, Coll Phys Educ, Dept Sports Coaching, Yongin, South Korea.
C3 Syracuse University; University of Louisiana System; University of
   Louisiana Monroe; Kyung Hee University; Kyung Hee University; Kyung Hee
   University
RP Jung, HC (corresponding author), Kyung Hee Univ, Sports Sci Res Ctr, Yongin, South Korea.; Jung, HC (corresponding author), Kyung Hee Univ, Coll Phys Educ, Dept Sports Coaching, Yongin, South Korea.
EM jhc@khu.ac.kr
RI Kim, Joon/I-9690-2016; Jung, Hyun/AAI-8359-2020; Lee,
   Jung-Min/L-8227-2016
OI Seo, Myong-Won/0000-0001-8545-4711; Kim, Joon Young/0000-0003-0448-1684;
   Lee, Jung-Min/0000-0002-8033-0725
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NR 46
TC 4
Z9 4
U1 0
U2 5
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 2296-2565
J9 FRONT PUBLIC HEALTH
JI Front. Public Health
PD MAY 25
PY 2023
VL 11
AR 1150121
DI 10.3389/fpubh.2023.1150121
PG 9
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA I4DK6
UT WOS:001002298700001
PM 37304116
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Kazakou, P
   Kyriazopoulou, V
   Michalaki, M
   Ierodiakonou, V
   Psyrogiannis, A
   Habeos, I
AF Kazakou, P.
   Kyriazopoulou, V.
   Michalaki, M.
   Ierodiakonou, V.
   Psyrogiannis, A.
   Habeos, I.
TI Activated Hypothalamic Pituitary Adrenal Axis in Patients with Metabolic
   Syndrome
SO HORMONE AND METABOLIC RESEARCH
LA English
DT Article
DE ACTH; cortisol; metabolic syndrome; glucocorticoids
ID HOMEOSTASIS MODEL ASSESSMENT; INDUCED CORTISOL SECRETION; STRESS-INDUCED
   CORTISOL; BODY-FAT DISTRIBUTION; INSULIN-RESISTANCE; ORAL GLUCOSE;
   ABDOMINAL OBESITY; PLASMA-CORTISOL; WOMEN; FOOD
AB Metabolic syndrome (MetS) is correlated with the activity of hypothalamic-pituitary-adrenal axis (HPA), but the underlying mechanism still remains elusive. The aim of this study was to investigate the HPA axis function in patients with MetS. This case-control study included 159 people. They were divided into 2 groups. The first group included 73 healthy volunteers (control group: 19 males, 54 females, mean +/- SD: 49.9 +/- 7.5 years old, with BMI: 27.9 +/- 4.42 kg/m(2)) and the second group included 86 patients with MetS (case group: 48 males, 38 females, mean +/- SD: 52.2 +/- 7.6 years old, with BMI: 30.5 +/- 5.35 kg/m 2). An oral glucose tolerance test (OGTT) was performed for all subjects after a 12-h overnight fast, and blood samples were obtained for determination of ACTH, cortisol, insulin, C-peptide, and glucose levels. Serum cortisol after an overnight dexamethasone suppression test was determined in both groups. Patients with MetS had serum cortisol levels after an overnight dexamethasone suppression test significantly higher than controls. During OGTT plasma ACTH levels were higher at all time points in patients with MetS compared to controls, whereas serum cortisol levels were comparable between the 2 groups. Plasma ACTH during OGTT was also correlated with most of the components of MetS. The HPA axis in patients with MetS seems to be more active as evidenced by the higher cortisol levels after the overnight dexamethasone suppression test and by the higher ACTH levels during OGTT. This functional hypercortisolism might be involved in the pathogenesis of the metabolic syndrome.
C1 [Kazakou, P.; Kyriazopoulou, V.; Michalaki, M.; Ierodiakonou, V.; Psyrogiannis, A.; Habeos, I.] Univ Patras, Sch Med, Div Endocrine, Diabet Ctr,Internal Med Dept, GR-26110 Patras, Greece.
C3 University of Patras
RP Kyriazopoulou, V (corresponding author), Univ Patras, Sch Med, Div Endocrine, Diabet Ctr,Internal Med Dept, GR-26110 Patras, Greece.
EM vkyriazopoulou@med.upatras.gr
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NR 41
TC 17
Z9 20
U1 0
U2 5
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0018-5043
EI 1439-4286
J9 HORM METAB RES
JI Horm. Metab. Res.
PD OCT
PY 2012
VL 44
IS 11
BP 839
EP 844
DI 10.1055/s-0032-1311632
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 018IY
UT WOS:000309654800008
PM 22549399
DA 2025-06-11
ER

PT J
AU Sanghez, V
   Cubuk, C
   Sebastián-Leon, P
   Carobbio, S
   Dopazo, J
   Vidal-Puig, A
   Bartolomucci, A
AF Sanghez, Valentina
   Cubuk, Cankut
   Sebastian-Leon, Patricia
   Carobbio, Stefania
   Dopazo, Joaquin
   Vidal-Puig, Antonio
   Bartolomucci, Alessandro
TI Chronic subordination stress selectively downregulates the insulin
   signaling pathway in liver and skeletal muscle but not in adipose tissue
   of male mice
SO STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS
LA English
DT Article
DE Adipose tissue; insulin; IRS1; IRS2; metabolic syndrome; obesity
ID HIGH-FAT-DIET; CHRONIC SOCIAL STRESS; PSYCHOSOCIAL STRESS; METABOLIC
   SYNDROME; INDUCED OBESITY; DIABETES-MELLITUS; VISCERAL OBESITY;
   ENERGY-BALANCE; MODEL; GLUCOCORTICOIDS
AB Chronic stress has been associated with obesity, glucose intolerance, and insulin resistance. We developed a model of chronic psychosocial stress (CPS) in which subordinate mice are vulnerable to obesity and the metabolic-like syndrome while dominant mice exhibit a healthy metabolic phenotype. Here we tested the hypothesis that the metabolic difference between subordinate and dominant mice is associated with changes in functional pathways relevant for insulin sensitivity, glucose and lipid homeostasis. Male mice were exposed to CPS for four weeks and fed either a standard diet or a high-fat diet (HFD). We first measured, by real-time PCR candidate genes, in the liver, skeletal muscle, and the perigonadal white adipose tissue (pWAT). Subsequently, we used a probabilistic analysis approach to analyze different ways in which signals can be transmitted across the pathways in each tissue. Results showed that subordinate mice displayed a drastic downregulation of the insulin pathway in liver and muscle, indicative of insulin resistance, already on standard diet. Conversely, pWAT showed molecular changes suggestive of facilitated fat deposition in an otherwise insulin-sensitive tissue. The molecular changes in subordinate mice fed a standard diet were greater compared to HFD-fed controls. Finally, dominant mice maintained a substantially normal metabolic and molecular phenotype even when fed a HFD. Overall, our data demonstrate that subordination stress is a potent stimulus for the downregulation of the insulin signaling pathway in liver and muscle and a major risk factor for the development of obesity, insulin resistance, and type 2 diabetes mellitus.
C1 [Sanghez, Valentina; Bartolomucci, Alessandro] Univ Minnesota, Dept Integrat Biol & Physiol, Minneapolis, MN USA.
   [Sanghez, Valentina] Univ Parma, Dept Neurosci, I-43100 Parma, Italy.
   [Cubuk, Cankut; Sebastian-Leon, Patricia; Dopazo, Joaquin] Ctr Invest Principe Felipe, Dept Computat Genom, Valencia, Spain.
   [Carobbio, Stefania; Vidal-Puig, Antonio] Univ Cambridge, Addenbrookes Hosp, Inst Metab Sci, Wellcome Trust MRC Metab Dis Unit, Cambridge CB2 2QQ, England.
   [Vidal-Puig, Antonio] Wellcome Trust Sanger Inst, Hinxton, England.
   [Sanghez, Valentina] Harbor UCLA Med Ctr, LABiomed Res Inst, Div Med Genet, Dept Pediat, Torrance, CA 90509 USA.
C3 University of Minnesota System; University of Minnesota Twin Cities;
   University of Parma; Prince Felipe Research Center; Cambridge University
   Hospitals NHS Foundation Trust; Addenbrooke's Hospital; University of
   Cambridge; Wellcome Trust Sanger Institute; University of California
   System; University of California Los Angeles; University of California
   Los Angeles Medical Center
RP Bartolomucci, A (corresponding author), Univ Minnesota, Dept Integrat Biol & Physiol, Minneapolis, MN USA.
EM abartolo@umn.edu
RI carobbio, stefania/E-7095-2018; SEBASTIAN-LEON, PATRICIA/AAA-8009-2020;
   Dopazo, Joaquin/A-9270-2014; Bartolomucci, Alessandro/MFI-6219-2025
OI Sanghez, Valentina/0000-0002-4131-7480; SEBASTIAN-LEON,
   PATRICIA/0000-0001-7299-3660; CUBUK, Cankut/0000-0003-4646-0849;
   Bartolomucci, Alessandro/0000-0001-6439-8829; Vidal-Puig,
   Antonio/0000-0003-4220-9577
FU UofMN Medical School; Medical Research Council; MRC Disease Model Core;
   British Heart Foundation; Spanish Ministry of Economy and
   Competitiveness [BIO2011-27069]; GVA-FEDER [PROMETEOII/2014/025];
   University of Parma; EU [316861]; MRC [MC_UU_12012/2, G0802051,
   MC_G0802535] Funding Source: UKRI
FX This work is supported by UofMN Medical School startup funds to AB,
   Medical Research Council, MRC Disease Model Core and British Heart
   Foundation program grants to AVP, and BIO2011-27069 from the Spanish
   Ministry of Economy and Competitiveness and PROMETEOII/2014/025 from the
   GVA-FEDER to J.D. V.S. was supported by a graduate student fellowship of
   the University of Parma. C.C. was supported by EU FP7-People Project(ref
   316861) "MLPM2012: Machine Learning For Personalized Medicine".
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NR 57
TC 9
Z9 11
U1 0
U2 13
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 1025-3890
EI 1607-8888
J9 STRESS
JI Stress
PD MAR
PY 2016
VL 19
IS 2
BP 214
EP 224
DI 10.3109/10253890.2016.1151491
PG 11
WC Behavioral Sciences; Endocrinology & Metabolism; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Behavioral Sciences; Endocrinology & Metabolism; Neurosciences &
   Neurology
GA DK1GA
UT WOS:000374659300010
PM 26946982
OA Green Published, hybrid, Green Submitted
DA 2025-06-11
ER

PT J
AU Anderson, RA
AF Anderson, Richard A.
TI Chromium and polyphenols from cinnamon improve insulin sensitivity
SO PROCEEDINGS OF THE NUTRITION SOCIETY
LA English
DT Article; Proceedings Paper
CT Summer Meeting of the Nutrition-Society
CY JUL 16-19, 2007
CL Univ Ulster, Coleraine, NORTH IRELAND
SP Nutr Soc Irish Sect
HO Univ Ulster
DE chromium; cinnamon polyphenols; insulin sensitivity; metabolic syndrome
ID CARCASS CHARACTERISTICS; METABOLIC SYNDROME; OXIDATIVE STRESS;
   BLOOD-GLUCOSE; BODY-WEIGHT; SUPPLEMENTATION; PICOLINATE; EXTRACT;
   RESISTANCE; PERFORMANCE
AB Naturally-occurring compounds that have been shown to improve insulin sensitivity include Cr and polyphenols found in cinnamon (Cinnamomon cassia). These compounds also have similar effects on insulin signalling and glucose control. The signs of Cr deficiency are similar to those for the metabolic syndrome and supplemental Cr has been shown to improve all these signs in human subjects. In a double-blind placebo-controlled study it has been demonstrated that glucose, insulin, cholesterol and HbA1c are all improved in patients with type 2 diabetes following Cr supplementation. It has also been shown that cinnamon polyphenols improve insulin sensitivity in in vitro, animal and human studies. Cinnamon reduces mean fasting serum glucose (18-29%), TAG (23-30%), total cholesterol (12-26%) and LDL-cholesterol (7-27%) in subjects with type 2 diabetes after 40d of daily consumption of 1-6g cinnamon. Subjects with the metabolic syndrome who consume an aqueous extract of cinnamon have been shown to have improved fasting blood glucose, systolic blood pressure, percentage body fat and increased lean body mass compared with the placebo group. Studies utilizing an aqueous extract of cinnamon, high in type A polyphenols, have also demonstrated improvements in fasting glucose, glucose tolerance and insulin sensitivity in women with insulin resistance associated with the polycystic ovary syndrome. For both supplemental Cr and cinnamon not all studies have reported beneficial effects and the responses are related to the duration of the study, form of Cr or cinnamon used and the extent of obesity and glucose intolerance of the subjects.
C1 USDA, Beltsville Human Nutr Res Ctr, Beltsville, MD 20705 USA.
C3 United States Department of Agriculture (USDA)
RP Anderson, RA (corresponding author), USDA, Beltsville Human Nutr Res Ctr, Beltsville, MD 20705 USA.
EM Richard.anderson@irs.usda.gov
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NR 45
TC 105
Z9 136
U1 1
U2 45
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0029-6651
EI 1475-2719
J9 P NUTR SOC
JI Proc. Nutr. Soc.
PD FEB
PY 2008
VL 67
IS 1
BP 48
EP 53
DI 10.1017/S0029665108006010
PG 6
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Nutrition & Dietetics
GA 265QE
UT WOS:000253375200006
PM 18234131
OA Bronze
DA 2025-06-11
ER

PT J
AU Ohno, Y
   Miyoshi, T
   Noda, Y
   Oe, H
   Toh, N
   Nakamura, K
   Kohno, K
   Morita, H
   Ito, H
AF Ohno, Yuko
   Miyoshi, Toru
   Noda, Yoko
   Oe, Hiroki
   Toh, Norihisa
   Nakamura, Kazufumi
   Kohno, Kunihisa
   Morita, Hiroshi
   Ito, Hiroshi
TI Bezafibrate improves postprandial hypertriglyceridemia and associated
   endothelial dysfunction in patients with metabolic syndrome: a
   randomized crossover study
SO CARDIOVASCULAR DIABETOLOGY
LA English
DT Article
DE Atherosclerosis; Bezafibrate; Triglyceride; Endothelium; Vasodilation
ID CORONARY-ARTERY-DISEASE; TYPE-2 DIABETES-MELLITUS; NONFASTING
   TRIGLYCERIDES; ATHEROSCLEROTIC PLAQUES; MYOCARDIAL-INFARCTION; SECONDARY
   PREVENTION; OXIDATIVE STRESS; STATIN THERAPY; HEART-DISEASE; CHOLESTEROL
AB Background: Postprandial elevation of triglyceride-rich lipoproteins impairs endothelial function, which can initiate atherosclerosis. We investigated the effects of bezafibrate on postprandial endothelial dysfunction and lipid profiles in patients with metabolic syndrome.
   Methods: Ten patients with metabolic syndrome were treated with 400 mg/day bezafibrate or untreated for 4 weeks in a randomized crossover study. Brachial artery flow-mediated dilation (FMD) and lipid profiles were assessed during fasting and after consumption of a standardized snack. Serum triglyceride and cholesterol contents of lipoprotein fractions were analyzed by high-performance liquid chromatography.
   Results: Postprandial FMD decreased significantly and reached its lowest value 4 h after the cookie test in both the bezafibrate and control groups, but the relative change in FMD from baseline to minimum in the bezafibrate group was significantly smaller than that in the control group (-29.0 +/- 5.9 vs. -42.9 +/- 6.2 %, p = 0.04). Bezafibrate significantly suppressed postprandial elevation of triglyceride (incremental area under the curve (AUC): 544 +/- 65 vs. 1158 +/- 283 mg h/dl, p = 0.02) and remnant lipoprotein cholesterol (incremental AUC: 27.9 +/- 3.5 vs. 72.3 +/- 14.1 mg h/dl, p < 0.01). High-performance liquid chromatography analysis revealed that postprandial triglyceride content of the chylomicron and very low-density lipoprotein fractions was significantly lower in the bezafibrate group than in the control group (p < 0.05).
   Conclusion: Bezafibrate significantly decreased postprandial endothelial dysfunction, and elevations of both exogenous and endogenous triglycerides in patients with metabolic syndrome, suggesting that bezafibrate may have vascular protective effects in these patients.
C1 [Ohno, Yuko; Noda, Yoko; Toh, Norihisa; Nakamura, Kazufumi; Kohno, Kunihisa; Morita, Hiroshi; Ito, Hiroshi] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Cardiovasc Med, Okayama 7008558, Japan.
   [Miyoshi, Toru] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Cardiovasc Therapeut, Okayama 7008558, Japan.
   [Oe, Hiroki] Okayama Univ Hosp, Ctr Ultrason Diagnost, Okayama, Japan.
C3 Okayama University; Okayama University; Okayama University
RP Miyoshi, T (corresponding author), Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Cardiovasc Therapeut, 2-5-1 Shikata Cho, Okayama 7008558, Japan.
EM miyoshit@cc.okayama-u.ac.jp
RI ohno, yuko/IWD-7759-2023
OI Nakamura, Kazufumi/0000-0001-8845-3626
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NR 41
TC 23
Z9 23
U1 0
U2 8
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1475-2840
J9 CARDIOVASC DIABETOL
JI Cardiovasc. Diabetol.
PD APR 5
PY 2014
VL 13
AR 71
DI 10.1186/1475-2840-13-71
PG 9
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism
GA AF6FF
UT WOS:000334809100001
PM 24708775
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Cruz, MME
   Sweetman, A
AF Meira e Cruz, Miguel
   Sweetman, Alexander
TI Comorbid Insomnia and Sleep Apnea: From Research to Clinical Practice
SO SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE
LA English
DT Review; Early Access
DE comorbid insomnia and sleep apnea (COMISA); obstructive sleep apnea
   (OSA); insomnia; sleep disorders; cardiometabolic risk
ID CO-MORBID INSOMNIA; SYMPTOMS; PREVALENCE; MANAGEMENT; METAANALYSIS;
   ASSOCIATION; PREDICTORS; ADULTS; RISK; OSA
AB Comorbid insomnia and sleep apnea (COMISA) represents a highly prevalent and clinically significant overlap between the two most common sleep disorders: insomnia and obstructive sleep apnea (OSA). COMISA is associated with greater impairment in sleep, daytime functioning, and physical and mental health compared with insomnia or OSA alone. Despite its prevalence, COMISA has historically been underrecognized, partially due to the conflicting symptoms of insomnia (e.g., hyperarousal and sleeplessness) and OSA (e.g., sleep fragmentation and excessive daytime sleepiness). Recent research highlights that COMISA is not merely the coexistence of insomnia and OSA but may involve unique pathophysiological interactions and clinical phenotypes. This review explores the epidemiology, mechanisms, and clinical manifestations of COMISA. We examine insomnia as a potential extension of OSA, where repeated apneic events lead to conditioned hyperarousal, as well as OSA as an extension of chronic insomnia through mechanisms such as autonomic dysregulation and respiratory instability. Furthermore, we consider COMISA as a distinct entity, characterized by bidirectional interactions between the two conditions that exacerbate their clinical and physiological burden. Key challenges in diagnosing COMISA are discussed, including overlapping symptoms and limitations in current assessment tools. Emerging evidence suggests that COMISA is associated with increased cardiovascular and metabolic risks, greater mental health burden, and reduced treatment adherence to positive airway pressure (PAP) therapy. Advances in tailored therapeutic approaches, including combined cognitive-behavioral therapy for insomnia and OSA management strategies, are highlighted as promising avenues to improve outcomes. Understanding COMISA as a multidimensional condition with diverse phenotypes and mechanisms underscores the need for integrated diagnostic frameworks and personalized treatment strategies to optimize patient care. Further research into its unique features and long-term consequences is critical to advancing clinical practice in sleep and respiratory medicine.
C1 [Meira e Cruz, Miguel; Sweetman, Alexander] Univ Lisboa CCUL RISE, Lisbon Fac Med, Ctr Cardiovasc, Sleep Unit, Av Prof Egas Moniz, P-1649028 Lisbon, Portugal.
   [Meira e Cruz, Miguel; Sweetman, Alexander] Ctr Europeu Sono, Lisbon, Portugal.
   [Meira e Cruz, Miguel; Sweetman, Alexander] Flinders Univ S Australia, Adelaide Inst Sleep Hlth, Bedford Pk, SA, Australia.
C3 Universidade de Lisboa; Adelaide Institute for Sleep Health; Flinders
   University South Australia
RP Cruz, MME (corresponding author), Univ Lisboa CCUL RISE, Lisbon Fac Med, Ctr Cardiovasc, Sleep Unit, Av Prof Egas Moniz, P-1649028 Lisbon, Portugal.
EM mcruz@medicina.ulisboa.pt
RI Sweetman, Alexander/AAE-8541-2019
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NR 72
TC 0
Z9 0
U1 0
U2 0
PU THIEME MEDICAL PUBL INC
PI NEW YORK
PA 333 SEVENTH AVE, NEW YORK, NY 10001 USA
SN 1069-3424
EI 1098-9048
J9 SEMIN RESP CRIT CARE
JI Semin. Respir. Crit. Care Med.
PD 2025 MAY 30
PY 2025
DI 10.1055/a-2591-5664
EA MAY 2025
PG 12
WC Critical Care Medicine; Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Respiratory System
GA 3FY9I
UT WOS:001499421500001
PM 40258387
DA 2025-06-11
ER

PT J
AU Rahbardar, MG
   Kakhki, HF
   Hosseinzadeh, H
AF Rahbardar, Mahboobeh Ghasemzadeh
   Kakhki, Homa Fazeli
   Hosseinzadeh, Hossein
TI Ziziphus jujuba (Jujube) in Metabolic Syndrome: From Traditional
   Medicine to Scientific Validation
SO CURRENT NUTRITION REPORTS
LA English
DT Review
DE Antioxidants; Hypoglycemic Agents; Phytochemicals; Anti-Inflammatory
   Agents; Betulinic Acid; Lupeol
ID ENDOTHELIUM-DEPENDENT RELAXATION; TYPE-2 DIABETIC-PATIENTS; BETULINIC
   ACID; OXIDATIVE STRESS; INSULIN-RESISTANCE; ADIPOSE-TISSUE;
   CARDIOVASCULAR-RESPONSES; THERAPEUTIC TARGET; LIPID-ACCUMULATION;
   ETHYL-ACETATE
AB Purpose of Review This review evaluates the therapeutic potential of Ziziphus jujuba and its main components in managing complications of metabolic syndrome, including diabetes, dyslipidemia, obesity, and hypertension. Recent Findings The reviewed studies provide evidence supporting the use of Z. jujuba and its main components (lupeol and betulinic acid) as natural treatments for complications of metabolic syndrome. These substances enhance glucose uptake through the activation of signaling pathways such as phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt), reduce hepatic glucose synthesis, and increase glucose uptake by adipocytes and skeletal muscle cells. They also improve insulin sensitivity by modulating AMP-activated protein kinase (AMPK) activity and regulating insulin signaling proteins and glucose transporters. In the field of dyslipidemia, they inhibit triglyceride synthesis, lipid accumulation, and adipogenic enzymes, while influencing key signaling pathways involved in adipogenesis. Z. jujuba and its constituents demonstrate anti-adipogenic effects, inhibiting lipid accumulation and modulating adipogenic enzymes and transcription factors. They also exhibit positive effects on endothelial function and vascular health by enhancing endothelial nitric oxide synthase (eNOS) expression, NO production, and antioxidant enzyme activity. Summary Z. jujuba, lupeol, and betulinic acid hold promise as natural treatments for complications of metabolic syndrome. They improve glucose metabolism, insulin sensitivity, and lipid profiles while exerting anti-adipogenic effects and enhancing endothelial function. However, further research is needed to elucidate the mechanisms and confirm their efficacy in clinical trials. These natural compounds offer potential as alternative therapies for metabolic disorders and contribute to the growing body of evidence supporting the use of natural medicines in their management.
C1 [Rahbardar, Mahboobeh Ghasemzadeh] Mashhad Univ Med Sci, Clin Res Inst, Transplant Res Ctr, Mashhad, Iran.
   [Kakhki, Homa Fazeli; Hosseinzadeh, Hossein] Mashhad Univ Med Sci, Sch Pharm, Dept Pharmacodynam & Toxicol, Mashhad, Iran.
   [Hosseinzadeh, Hossein] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Pharmaceut Res Ctr, Mashhad, Iran.
C3 Mashhad University of Medical Sciences; Mashhad University of Medical
   Sciences; Mashhad University of Medical Sciences
RP Hosseinzadeh, H (corresponding author), Mashhad Univ Med Sci, Sch Pharm, Dept Pharmacodynam & Toxicol, Mashhad, Iran.; Hosseinzadeh, H (corresponding author), Mashhad Univ Med Sci, Pharmaceut Technol Inst, Pharmaceut Res Ctr, Mashhad, Iran.
EM hosseinzadehh@mums.ac.ir
RI Ghasemzadeh Rahbardar, Mahboobeh/V-4452-2019; Hosseinzadeh,
   Hossein/F-3013-2010
OI Hosseinzadeh, Hossein/0000-0002-3483-851X; Ghasemzadeh Rahbardar,
   Mahboobeh/0000-0002-5491-572X
FU Pharmaceutical Research Center
FX This work was supported by the Pharmaceutical Research Center and the
   Vice Chancellor of Research, at Mashhad University of Medical Sciences.
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NR 149
TC 5
Z9 5
U1 6
U2 11
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
EI 2161-3311
J9 CURR NUTR REP
JI Curr. Nutr. Rep.
PD DEC
PY 2024
VL 13
IS 4
BP 845
EP 866
DI 10.1007/s13668-024-00581-5
EA OCT 2024
PG 22
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA J2S9D
UT WOS:001326644200001
PM 39354208
DA 2025-06-11
ER

PT J
AU dos Santos, LL
   Silva, ATB
   da Cruz, MADP
   da Rosa, SE
   Fortes, MDR
   Nunes, RDM
   de Castro, JBP
   Linhares, DG
   dos Santos, AOB
   Cordeiro, LD
   Borba-Pinheiro, CJ
   Vale, RGD
AF dos Santos, Luciano Lima
   Silva, Aline Tito Barbosa
   da Cruz, Marcos Alexandre de Souza Pecanha
   da Rosa, Samir Ezequiel
   Fortes, Marcos de Sa Rego
   Nunes, Rodolfo de Alkmim Moreira
   de Castro, Juliana Brandao Pinto
   Linhares, Diego Gama
   dos Santos, Andressa Oliveira Barros
   Cordeiro, Lilliany de Souza
   Borba-Pinheiro, Claudio Joaquim
   Vale, Rodrigo Gomes de Souza
TI Effects of Long and Sprint High-Intensity Interval Training on Body Mass
   Composition, Aerobic Capacity, and Biochemical Markers of Metabolic
   Syndrome and Liver Damage in Physical Activity Practitioners Adults
SO MLTJ-MUSCLES LIGAMENTS AND TENDONS JOURNAL
LA English
DT Article
DE Metabolic syndrome; metabolic associated fatty liver disease;
   high-intensity long interval training; sprint interval training;
   training impulse
ID VISCERAL FAT; EXERCISE; PERFORMANCE; PROGRAM
AB Background. Highlights High -Intensity Long Interval Training (HILIT) and Sprint Interval Training (SIT) to morpho functional improvement and reduce effects of Metabolic Associated Fatty Liver Disease (MAFLD) and the Metabolic Syndrome (MS). Objective. This study aims to verify the effects of HILIT and SIT on physiological and pathological markers of MS and liver health in adults submitted to 12 weeks of training. Methods. A randomized clinical trial was carried out with a design for two groups, HILIT and SIT Groups. The sample consisted of 38 physical activity practitioners male adults aged between 30 and 55 years (42.75 +/- 8.26). Body composition assessments, cardiac stress tests, measurements of blood pressure (BP), and blood samples were analyzed: triglycerides (TRIG), high -density lipoprotein (HDL-C) and glucose (GLU) and liver damage: Albumin (ALB), Bilirubin (BIL), Aspartate Aminotransferase (AST), Alamine Aminotransferase (ALT), Gamma Glutamyl Transferase (GGT). Results. For HILIT there was a significant intragroup improvement in the parameters of fat mass, lean mass, body mass index (BMI), visceral adipose fat (VAT), GLU, ALB, Direct Bilirubin (DB), distance run, and oxygen consumption (VO2). For SIT there was a significant intragroup improvement in the parameters of VAT, GLU, ALB, DB, GGT, and distance run. There was a significant difference in the intergroup comparison only for BP in favor of the SIT group. Conclusions. We conclude that 12 weeks of HILIT and SIT interval training were able to produce positive effects on body composition variables, aerobic capacity, Metabolic Syndrome, and Liver Health in physical activity practitioners adult men, with better results for HILIT in this population.
C1 [dos Santos, Luciano Lima; Nunes, Rodolfo de Alkmim Moreira; de Castro, Juliana Brandao Pinto; Linhares, Diego Gama; dos Santos, Andressa Oliveira Barros; Cordeiro, Lilliany de Souza; Vale, Rodrigo Gomes de Souza] Univ Estado Rio De Janeiro, Postgrad Program Exercise & Sport Sci, Rio De Janeiro, Brazil.
   [dos Santos, Luciano Lima; Nunes, Rodolfo de Alkmim Moreira; de Castro, Juliana Brandao Pinto; Linhares, Diego Gama; dos Santos, Andressa Oliveira Barros; Cordeiro, Lilliany de Souza; Vale, Rodrigo Gomes de Souza] Univ Estado Rio De Janeiro, Inst Phys Educ & Sports, Lab Exercise & Sport, Rio De Janeiro, Brazil.
   [Borba-Pinheiro, Claudio Joaquim] Para State Univ, Fed Inst Para, Belem, Para, Brazil.
   [Silva, Aline Tito Barbosa; da Cruz, Marcos Alexandre de Souza Pecanha; da Rosa, Samir Ezequiel; Fortes, Marcos de Sa Rego] Army Phys Training Res Inst, Rio De Janeiro, Brazil.
C3 Universidade do Estado do Rio de Janeiro; Universidade do Estado do Rio
   de Janeiro; Instituto Federal do Para; Universidade do Estado do Para
   (UEPA)
RP dos Santos, LL (corresponding author), Univ Estado Rio De Janeiro, R Sao Francisco Xavier 524, BR-20550013 Maracana, RJ, Brazil.
EM luciano.pentatlo@hotmail.com
RI DA ROSA, SAMIR/ABB-9329-2021; Linhares, Diego/LYO-9815-2024; Vale,
   Rodrigo/F-7429-2012; Castro, Juliana/E-5338-2016
OI Gama Linhares, Diego/0000-0002-2901-3273
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NR 58
TC 0
Z9 0
U1 1
U2 1
PU EDRA SPA
PI MILANO
PA VIA G SPADOLINI, 7, MILANO, 20141, ITALY
SN 2240-4554
J9 MLTJ-MUSCLE LIGAMENT
JI MLTJ-Muscles Ligaments Tendons J.
PD APR-JUN
PY 2024
VL 14
IS 2
BP 256
EP 268
DI 10.32098/mltj.02.2024.04
PG 13
WC Orthopedics
WE Emerging Sources Citation Index (ESCI)
SC Orthopedics
GA WK4W5
UT WOS:001254760300005
OA Bronze
DA 2025-06-11
ER

PT J
AU Taghizadeh, N
   Sharifan, P
   Toosi, MSE
   Doust, FNS
   Darroudi, S
   Afshari, A
   Rezaie, M
   Safarian, M
   Vatanparast, H
   Eslami, S
   Ghazizadeh, H
   Khorasanchi, Z
   Bagherniya, M
   Ferns, G
   Darban, RA
   Ghayour-Mobarhan, M
AF Taghizadeh, Niloofar
   Sharifan, Payam
   Toosi, Mansoureh Sadat Ekhteraee
   Doust, Fatemeh Najar Sedgh
   Darroudi, Susan
   Afshari, Asma
   Rezaie, Mitra
   Safarian, Mohamad
   Vatanparast, Hassan
   Eslami, Saeed
   Ghazizadeh, Hamideh
   Khorasanchi, Zahra
   Bagherniya, Mohammad
   Ferns, Gordon
   Darban, Reza Assaran
   Ghayour-Mobarhan, Majid
TI The effects of consuming a low-fat yogurt fortified with nano
   encapsulated vitamin D on serum pro-oxidant-antioxidant balance (PAB) in
   adults with metabolic syndrome; a randomized control trial
SO DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS
LA English
DT Article
DE Vitamin D; Fortification; Prooxidant-antioxidant balance; Metabolic
   syndrome; Nano encapsulation
ID D DEFICIENCY; OXIDATIVE STRESS; DAIRY-PRODUCTS; PROBIOTIC YOGURT;
   DISEASE-ACTIVITY; CROHNS-DISEASE; ASSOCIATION; CALCIUM; INFLAMMATION;
   ANTICANCER
AB Background and aim: The current study aimed to assess the effect of fortified yogurt with nano-encapsulated vitamin D on serum pro-oxidant anti-oxidant balance (PAB) in adults with or without metabolic syndrome.
   Methods: In a quadruple blind clinical trial study, 139 adults with an age range of 30-50 years were randomly selected to receive either 1500 IU nano-encapsulated vitamin D fortified yogurt or placebo for ten weeks. Before and after the intervention period, blood sample was taken to determine the serum levels of vitamin D, pro-oxidant-antioxidant balance (PAB), and high-sensitivity C-reactive protein (hs-CRP). The laboratory tests were checked at baseline and at the end of the treatment.
   Results: Serum vitamin D increased significantly, from 14.47 +/- 6.07 ng/mL to 21.39 +/- 6.54 ng/mL (P < 0.001) after ten weeks in the intervention group. Serum hs-CRP and PAB were significantly lower following consumption period in intervention group [1.95(0.4-8.15) g/dL vs. 1.35(0.25-3.62) g/dL; P = 0.013] and (135.19 +/- 42.4 HK vs. 115.39 +/- 44.69) HK; P = 0.018] respectively. There were no significant differences between the intervention and control groups regarding weight and BMI at the end of the intervention period (p > 0.05).
   Conclusion: Low-fat yogurt fortified with nano-encapsulated vitamin D was found to reduce serum PAB levels in adults with metabolic syndrome. (C) 2021 Diabetes India. Published by Elsevier Ltd. All rights reserved.
C1 [Taghizadeh, Niloofar; Toosi, Mansoureh Sadat Ekhteraee; Doust, Fatemeh Najar Sedgh; Darban, Reza Assaran] Islamic Azad Univ, Fac Sci, Dept Biol, Mashhad Branch, Mashhad, Razavi Khorasan, Iran.
   [Sharifan, Payam; Afshari, Asma; Rezaie, Mitra; Safarian, Mohamad; Khorasanchi, Zahra; Ghayour-Mobarhan, Majid] Mashhad Univ Med Sci, Sch Med, Dept Nutr, Mashhad, Razavi Khorasan, Iran.
   [Darroudi, Susan; Ghazizadeh, Hamideh; Ghayour-Mobarhan, Majid] Mashhad Univ Med Sci, Int UNESCO Ctr Hlth Related Basic Sci & Human Nut, Mashhad, Razavi Khorasan, Iran.
   [Sharifan, Payam; Ghazizadeh, Hamideh] Mashhad Univ Med Sci, Sch Med, Student Res Comm, Mashhad, Razavi Khorasan, Iran.
   [Vatanparast, Hassan] Univ Saskatchewan, Coll Pharm & Nutr, Saskatoon, SK, Canada.
   [Eslami, Saeed] Mashhad Univ Med Sci, Pharmaceut Res Ctr, Sch Pharm, Mashhad, Razavi Khorasan, Iran.
   [Bagherniya, Mohammad] Isfahan Univ Med Sci, Food Secur Res Ctr, Sch Nutr & Food Sci, Dept Community Nutr, Esfahan, Iran.
   [Ferns, Gordon] Brighton & Sussex Med Sch, Div Med Educ, Brighton, E Sussex, England.
C3 Islamic Azad University; Mashhad University of Medical Sciences; Mashhad
   University of Medical Sciences; Mashhad University of Medical Sciences;
   University of Saskatchewan; Mashhad University of Medical Sciences;
   Isfahan University of Medical Sciences; University of Brighton;
   University of Sussex
RP Darban, RA (corresponding author), Islamic Azad Univ, Fac Sci, Dept Biol, Mashhad Branch, Mashhad, Razavi Khorasan, Iran.; Ghayour-Mobarhan, M (corresponding author), Mashhad Univ Med Sci, Metab Syndrome Res Ctr, Mashhad 9919991766, Razavi Khorasan, Iran.
EM mrassaran78@gmail.com; ghayourm@mums.ac.ir
RI Ghayour-Mobarhan, Majid/AAY-5963-2020; Ghazizadeh,
   Hamideh/ABE-8941-2020; khorasanchi, zahra/ABD-4405-2021; Afshari,
   Asma/AAW-9511-2020; Assaran Draban, Reza/S-3572-2017
OI khorasanchi, zahra/0000-0001-9579-9465
FU Elite Researcher Grant Committee from the National Institutes for
   Medical Research Development (NIMAD), Tehran, Iran [957705]; Mashhad
   University of Medical Sciences (MUMS), Mashhad, Iran
FX Research reported in this publication was supported by Elite Researcher
   Grant Committee under award number [957705] from the National Institutes
   for Medical Research Development (NIMAD), Tehran, Iran and Mashhad
   University of Medical Sciences (MUMS), Mashhad, Iran.
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NR 53
TC 21
Z9 24
U1 0
U2 6
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1871-4021
EI 1878-0334
J9 DIABETES METAB SYND
JI Diabetes Metab. Syndr.-Clin. Res. Rev.
PD NOV-DEC
PY 2021
VL 15
IS 6
AR 102332
DI 10.1016/j.dsx.2021.102332
EA NOV 2021
PG 7
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA XK6BU
UT WOS:000727549300029
PM 34781136
DA 2025-06-11
ER

PT J
AU Kim, NH
   Han, KH
   Choi, J
   Lee, J
   Kim, SG
AF Kim, Nam Hoon
   Han, Ki Hoon
   Choi, Jimi
   Lee, Juneyoung
   Kim, Sin Gon
TI Use of fenofibrate on cardiovascular outcomes in statin users with
   metabolic syndrome: propensity matched cohort study
SO BMJ-BRITISH MEDICAL JOURNAL
LA English
DT Article
ID RESIDUAL RISK; DISEASE; THERAPY; EVENTS; CHOLESTEROL; METAANALYSIS;
   REDUCTION; MORTALITY; SURVIVAL; STRESS
AB OBJECTIVE
   To investigate whether fenofibrate as add-on to statin treatment reduce persistent cardiovascular risk in adults with metabolic syndrome in a real world setting.
   DESIGN
   Propensity matched cohort study.
   SETTING
   Population based cohort in Korea.
   PARTICIPANTS
   29 771 adults with metabolic syndrome (>= 40 years) receiving statin treatment. 2156 participants receiving combined treatment (statin plus fenofibrate) were weighted based on propensity score in a 1:5 ratio with 8549 participants using statin only treatment.
   MAIN OUTCOME MEASURE
   Primary outcome was composite cardiovascular events including incident coronary heart disease, ischaemic stroke, and death from cardiovascular causes.
   RESULTS
   The incidence rate per 1000 person years of composite cardiovascular events was 17.7 (95% confidence interval 14.4 to 21.8) in the combined treatment group and 22.0 (20.1 to 24.1) in the statin group. The risk of composite cardiovascular events was significantly reduced in the combined treatment group compared with statin group (adjusted hazard ratio 0.74, 95% confidence interval 0.58 to 0.93; P=0.01). The significance was maintained in the on-treatment analysis (hazard ratio 0.63, 95% confidence interval 0.44 to 0.92; P=0.02). The risk of incident coronary heart disease, ischaemic stroke, and cardiovascular death was lower in the combined treatment group than statin group but was not significant. Participant characteristics did not appear to be associated with the low risk of composite cardiovascular events with combined treatment.
   CONCLUSION
   In this propensity weighted cohort study of adults with metabolic syndrome, the risk of major cardiovascular events was significantly lower with fenofibrate as add-on to statin treatment than with statin treatment alone.
C1 [Kim, Nam Hoon; Kim, Sin Gon] Korea Univ, Coll Med, Anam Hosp, Div Endocrinol & Metab,Dept Internal Med, 126-1,Anam Dong 5 Ga, Seoul 02841, South Korea.
   [Han, Ki Hoon] Ulsan Univ, Dept Internal Med, Seoul, South Korea.
   [Choi, Jimi; Lee, Juneyoung] Korea Univ, Coll Med, Dept Biostat, Seoul, South Korea.
C3 Korea University; Korea University Medicine (KU Medicine); University of
   Ulsan; Korea University; Korea University Medicine (KU Medicine)
RP Kim, SG (corresponding author), Korea Univ, Coll Med, Anam Hosp, Div Endocrinol & Metab,Dept Internal Med, 126-1,Anam Dong 5 Ga, Seoul 02841, South Korea.
EM k50367@korea.ac.kr
RI Choi, So/AAV-1947-2020; Lee, Jun Young/CAI-2335-2022; Kim, Nam
   Hoon/HNS-5794-2023; Kim, Sin Gon/KQU-7757-2024
OI Lee, Juneyoung/0000-0001-8073-9304; Kim, Sin Gon/0000-0002-7430-3675;
   Kim, Nam Hoon/0000-0002-9926-1344
FU Abbott Laboratories Korea
FX This study was supported by the Abbott Laboratories Korea. The funders
   had no role in the design and conduct of the study; analysis,
   preparation, review, and approval of the manuscript.
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NR 40
TC 52
Z9 53
U1 0
U2 9
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 0959-535X
EI 1756-1833
J9 BMJ-BRIT MED J
JI BMJ-British Medical Journal
PD SEP 27
PY 2019
VL 366
AR l5125
DI 10.1136/bmj.l5125
PG 9
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA JB3XM
UT WOS:000488490200001
PM 31562117
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Seale, LA
   Gilman, CL
   Hashimoto, AC
   Ogawa-Wong, AN
   Berry, MJ
AF Seale, Lucia A.
   Gilman, Christy L.
   Hashimoto, Ann C.
   Ogawa-Wong, Ashley N.
   Berry, Marla J.
TI Diet-Induced Obesity in the Selenocysteine Lyase Knockout Mouse
SO ANTIOXIDANTS & REDOX SIGNALING
LA English
DT Article
ID NECROSIS-FACTOR-ALPHA; HUMAN BETA-CELLS; SELENOPROTEIN-P;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; SELENIUM STATUS;
   GLUTATHIONE-PEROXIDASE; METABOLIC SYNDROME; FATTY LIVER; VITAMIN-E
AB Aims: Selenocysteine lyase (Scly) mediates selenocysteine decomposition. It was previously demonstrated that, upon adequate caloric intake (12% kcal fat) and selenium deficiency, disruption of Scly in mice leads to development of metabolic syndrome. In this study, we investigate the effect of a high-fat (45% kcal) selenium-adequate diet in Scly knockout (KO) mice on development of metabolic syndrome. Involvement of selenoproteins in energy metabolism after Scly disruption was also examined in vitro in the murine hepatoma cell line, Hepa1-6, following palmitate treatment. Results: Scly KO mice were more susceptible to diet-induced obesity than their wild-type counterparts after feeding a high-fat selenium-adequate diet. Scly KO mice had aggravated hyperinsulinemia, hypercholesterolemia, glucose, and insulin intolerance, but unchanged inflammatory cytokines and expression of most selenoproteins, except increased serum selenoprotein P (Sepp1). Scly KO mice also exhibited enhanced hepatic levels of pyruvate and enzymes involved in the regulation of pyruvate cycling, such as pyruvate carboxylase (Pcx) and pyruvate dehydrogenase (Pdh). However, in vitro silencing of Scly in Hepa1-6 cells led to diminished Sepp1 expression, and concomitant palmitate treatment decreased Pdh expression. Innovation: The role of selenium in lipid metabolism is recognized, but specific selenium-dependent mechanisms leading to obesity are unclear. This study uncovers that Scly has a remarkable effect on obesity and metabolic syndrome development triggered by high-fat exposure, independent of the expression of most selenoproteins. Conclusion: Diet-induced obesity in Scly KO mice is aggravated, with effects on pyruvate levels and consequent activation of energy metabolism independent of selenoprotein levels. Antioxid. Redox Signal. 23, 761-774.
C1 [Seale, Lucia A.; Gilman, Christy L.; Hashimoto, Ann C.; Ogawa-Wong, Ashley N.; Berry, Marla J.] Univ Hawaii Manoa, John A Burns Sch Med, Dept Cell & Mol Biol, Honolulu, HI 96813 USA.
C3 University of Hawaii System; University of Hawaii Manoa
RP Seale, LA (corresponding author), Univ Hawaii Manoa, John A Burns Sch Med, Dept Cell & Mol Biol, 651 Ilalo St,BSB222, Honolulu, HI 96813 USA.
EM lseale@hawaii.edu
RI Seale, Lucia/AFT-9036-2022
OI Seale, Lucia/0000-0002-0686-7516
FU National Institutes of Health [R01-DK47320, G12-MD007601]; Pilot Project
   Award [G12-MD007601]
FX This work was funded by the National Institutes of Health, grants
   R01-DK47320 and G12-MD007601 to MJB, and Pilot Project Award funds from
   G12-MD007601 to LAS. Image of WT and Scly KO mice in Figure 1A was a
   courtesy of Ann Hashimoto. We thank FuKun Hoffmann, Maile O'Connell,
   Madhuri Namekar, Brooks Mitchell, and the COBRE Molecular and Cellular
   Immunology Core Facility at the University of Hawaii for helping with
   flow cytometry, and Dr. Frederick Bellinger for providing the mouse
   Sepp1 antibody. LAS designed and performed experiments, analyzed data,
   and wrote the article. ACH, ANO, and CLG performed experiments, analyzed
   data, and contributed with analytical tools. MJB mentored in all
   research steps. All authors discussed and reviewed the article.
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NR 75
TC 34
Z9 36
U1 0
U2 27
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1523-0864
EI 1557-7716
J9 ANTIOXID REDOX SIGN
JI Antioxid. Redox Signal.
PD OCT 1
PY 2015
VL 23
IS 10
BP 761
EP 774
DI 10.1089/ars.2015.6277
PG 14
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA CS0LI
UT WOS:000361750400002
PM 26192035
OA Green Published
DA 2025-06-11
ER

PT J
AU Huzen, J
   Wong, LSM
   van Veldhuisen, DJ
   Samani, NJ
   Zwinderman, AH
   Codd, V
   Cawthon, RM
   Benus, GFJD
   van der Horst, ICC
   Navis, G
   Bakker, SJL
   Gansevoort, RT
   de Jong, PE
   Hillege, HL
   van Gilst, WH
   de Boer, RA
   van der Harst, P
AF Huzen, J.
   Wong, L. S. M.
   van Veldhuisen, D. J.
   Samani, N. J.
   Zwinderman, A. H.
   Codd, V.
   Cawthon, R. M.
   Benus, G. F. J. D.
   van der Horst, I. C. C.
   Navis, G.
   Bakker, S. J. L.
   Gansevoort, R. T.
   de Jong, P. E.
   Hillege, H. L.
   van Gilst, W. H.
   de Boer, R. A.
   van der Harst, P.
TI Telomere length loss due to smoking and metabolic traits
SO JOURNAL OF INTERNAL MEDICINE
LA English
DT Article
DE ageing; biomarker; metabolic syndrome; smoking; telomeres
ID CORONARY-ARTERY-DISEASE; OXIDATIVE STRESS; LONGITUDINAL FINDINGS; HEART;
   ASSOCIATION; MORTALITY; DYNAMICS; BLOOD; LIFE
AB ObjectivesHuman age-dependent telomere attrition and telomere shortening are associated with several age-associated diseases and poorer overall survival. The aim of this study was to determine longitudinal leucocyte telomere length dynamics and identify factors associated with temporal changes in telomere length.
   Design and MethodsLeucocyte telomere length was measured by quantitative polymerase chain reaction in 8074 participants from the Prevention of Renal and Vascular End-stage Disease (PREVEND) study, an ongoing community-based prospective cohort study initiated in 1997. Follow-up data were available at two time-points up to 2007. Leucocyte telomere length was measured, on between one and three separate occasions, in a total of 16783 DNA samples. Multilevel growth models were created to identify the factors that influence leucocyte telomere dynamics.
   ResultsWe observed an average attrition rate of 0.470.16 relative telomere length units (RTLUs) per year in the study population aged 48 (range 39-60) years at baseline. Annual telomere attrition rate increased with age (P<0.001) and was faster on average in men than in women (P for interaction 0.043). The major independent factors determining telomere attrition rate were active smoking (approximately tripled the loss of RTLU per year, P<0.0001) and multiple traits of the metabolic syndrome (waist-hip ratio, P=0.007; blood glucose level, P=0.045, and HDL cholesterol level, P<0.001).
   ConclusionsSmoking and variables linked to the metabolic syndrome are modifiable lifestyle factors that accelerate telomere attrition in humans. The higher rate of cellular ageing may mediate the link between smoking and the metabolic syndrome to an increased risk of several age-associated diseases.
C1 [Huzen, J.; Wong, L. S. M.; van Veldhuisen, D. J.; Benus, G. F. J. D.; van der Horst, I. C. C.; Hillege, H. L.; van Gilst, W. H.; de Boer, R. A.; van der Harst, P.] Univ Groningen, Univ Med Ctr Groningen, Dept Cardiol, Groningen, Netherlands.
   [Samani, N. J.; Codd, V.] Univ Leicester, Glenfield Hosp, Dept Cardiovasc Sci, Leicester, Leics, England.
   [Zwinderman, A. H.] Univ Amsterdam, Acad Med Ctr, Dept Clin Epidemiol & Biostat, NL-1105 AZ Amsterdam, Netherlands.
   [Cawthon, R. M.] Univ Utah, Dept Human Genet, Salt Lake City, UT USA.
   [Navis, G.; Bakker, S. J. L.; Gansevoort, R. T.; de Jong, P. E.] Univ Groningen, Univ Med Ctr Groningen, Dept Internal Med, Groningen, Netherlands.
   [van der Harst, P.] ICIN Netherlands Heart Inst, Durrer Ctr Cardiogenet Res, Utrecht, Netherlands.
C3 University of Groningen; University Hospitals of Leicester NHS Trust;
   University of Leicester; Glenfield Hospital; University of Amsterdam;
   Academic Medical Center Amsterdam; Utah System of Higher Education;
   University of Utah; University of Groningen
RP van der Harst, P (corresponding author), Univ Med Ctr Groningen, Dept Cardiol, Hanzepl 1, NL-9700 RB Groningen, Netherlands.
EM p.van.der.harst@umcg.nl
RI van Veldhuisen, Dirk/E-8967-2014; van Gilst, Wiek/AFM-7606-2022; van der
   Horst, Iwan/AFU-8433-2022; van der Harst, Pim/HOH-5622-2023; Bakker,
   Stephan/J-4023-2015; de Boer, Rudolf/HMW-1849-2023
OI Codd, Veryan/0000-0002-9430-8254; van der Harst,
   Pim/0000-0002-2713-686X; Bakker, Stephan/0000-0003-3356-6791; de Boer,
   Rudolf/0000-0002-4775-9140; van Gilst, Wiek/0000-0003-2968-8585
FU Netherlands Heart Foundation [2006B140, 2006T003, 2008T028];
   Innovational Research Incentives Scheme of the Netherlands Organization
   for Scientific Research (NWO VENI) [916.76.170]; British Heart
   Foundation; Leicester NIHR Bio-medical Research Unit in Cardiovascular
   Disease
FX This work was supported by grants from the Netherlands Heart Foundation
   (Grant Numbers 2006B140, 2006T003, 2008T028) and the Innovational
   Research Incentives Scheme of the Netherlands Organization for
   Scientific Research (NWO VENI, Grant Number 916.76.170 to PvdH). PvdH is
   a research fellow of the Interuniversity Cardiology Institute of the
   Netherlands (ICIN). NJS holds a Chair funded by the British Heart
   Foundation, and NJS and VC are supported by the Leicester NIHR
   Bio-medical Research Unit in Cardiovascular Disease.
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NR 40
TC 145
Z9 158
U1 3
U2 25
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0954-6820
EI 1365-2796
J9 J INTERN MED
JI J. Intern. Med.
PD FEB
PY 2014
VL 275
IS 2
BP 155
EP 163
DI 10.1111/joim.12149
PG 9
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 290NG
UT WOS:000329764500007
PM 24118582
OA hybrid, Green Submitted
DA 2025-06-11
ER

PT J
AU Schilling, R
   Colledge, F
   Pühse, U
   Gerber, M
AF Schilling, Rene
   Colledge, Flora
   Puehse, Uwe
   Gerber, Markus
TI Stress-buffering effects of physical activity and cardiorespiratory
   fitness on metabolic syndrome: A prospective study in police officers
SO PLOS ONE
LA English
DT Article
ID EFFORT-REWARD IMBALANCE; CORONARY-HEART-DISEASE; CARDIOVASCULAR
   RISK-FACTOR; OF-THE-ART; PERCEIVED STRESS; HAIR CORTISOL; WORK; HEALTH;
   PREVALENCE; FREQUENCY
AB Metabolic syndrome (MetS) is a worldwide health concern related to cardiovascular disease. Stress at work increases the risk for MetS, whereas physical activity and cardiorespiratory fitness (CF) have been shown to be potential buffers against stress. The aim of this study was to test the stress-buffering effects of physical activity and CF on the relationship between work stress and MetS. In a prospective study, we followed 97 police officers (mean age = 39.7 years; mean body mass index = 25.74 kg/m(2)) over one year and assessed MetS, as defined by the National Cholesterol Education Program Adult Treatment Panel III. Stress at work was measured with the Job Content Questionnaire, as well as the Effort-Reward Imbalance Questionnaire. Physical activity was assessed objectively via 7-day accelerometry. CF was assessed with the angstrom strand bicycle ergometer test. Hierarchical linear regression models were carried out to predict MetS at follow-up (mean overall MetS score = 1.22), after controlling for baseline levels and sociodemographic background (mean overall MetS score = 1.19). Higher CF levels were significantly associated with lower MetS risk at follow-up (beta = -.38). By contrast, no main effects were found for physical activity and work stress. However, high effort and demand were significantly correlated with increased blood pressure (effort:r= .23 for systolic blood pressure;r= .21 for diastolic blood pressure) and waist circumference (effort:r= .26; demand:r= .23). Moreover, no significant interaction effects occurred between work stress and CF/physical activity. The results emphasize the importance of high levels of CF in the prevention of MetS in police officers. Accordingly, provision of regular training opportunities and repeated CF testing should be considered as a strategy in overall corporate health promotion.
C1 [Schilling, Rene; Colledge, Flora; Puehse, Uwe; Gerber, Markus] Univ Basel, Dept Sport Exercise & Hlth, Basel, Switzerland.
C3 University of Basel; Swiss School of Public Health (SSPH+)
RP Schilling, R (corresponding author), Univ Basel, Dept Sport Exercise & Hlth, Basel, Switzerland.
EM rene.schilling@unibas.ch
RI Gerber, Markus/H-8654-2014
OI vandoni, matteo/0000-0002-3405-9364
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NR 82
TC 11
Z9 13
U1 0
U2 9
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JUL 28
PY 2020
VL 15
IS 7
AR e0236526
DI 10.1371/journal.pone.0236526
PG 21
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Science & Technology - Other Topics
GA MW3BD
UT WOS:000556916000042
PM 32722703
OA Green Accepted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Chien, YH
   Yu, YH
   Chen, YW
AF Chien, Yi-Hsuan
   Yu, Yu-Hsiang
   Chen, Yue-Wen
TI Taiwanese green propolis ameliorates metabolic syndrome via remodeling
   of white adipose tissue and modulation of gut microbiota in diet-induced
   obese mice
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Article
DE Taiwanese green propolis; White adipose tissue; Brown adipose tissue;
   Metabolic syndrome; Gut microbiota
ID INSULIN-RESISTANCE; LIPID-METABOLISM; FAT ACCUMULATION; PLANT-ORIGIN;
   BROWN FAT; PATHOGENESIS; POLYPHENOLS; APOPTOSIS; ADIPOKINE; BENEFITS
AB Excessive energy intake leads to dysbiosis of intestinal microbiota and puts surrounding tissues under oxidative stress and inflammation, contributing to the development of metabolic syndrome. Taiwanese green propolis (TGP) exhibits a broad spectrum of biological activities, including anti-bacterial, anti-inflammatory, and antioxidant properties. However, the benefits of TGP on metabolic syndrome have not been explained in detail. In this study, we examined the preventive effects of TGP on high-fat diet (HFD)-induced obesity. The results showed that TGP supplementation at 1000 ppm improved condition such as hyperlipidemia, fat accumulation, liver steatosis, and whitening of brown adipose tissue (BAT) in mice. In addition, we observed more cold-induced nonshivering thermogenesis by BAT in TGP treatment with 1000 ppm group. At lower dose of 500 ppm, TGP improved glucose intolerance and insulin insensitivity in HFD mice and restructured the composition of gut microbiota to reduce dysbiosis, which involved an increase in the abundance of metabolism-related bacteria such as Lachnospiraceae NK4A136 group and the decrease in Desulfovibrio. The change of dominant microbiota was associated with the homeostasis of blood glucose and lipid. Transcriptome and micro-western array analysis revealed that TGP supplementation at 500 ppm promoted the browning and adipogenesis in white adipose tissue (WAT), blocked inflammation signaling and attenuated reactive oxygen species, contributing to healthy WAT remodeling and offsetting negative metabolic effects of obesity. We concluded that TGP modulated the function of BAT, WAT, and gut microbiota, bringing a balance to the glucose and lipid homeostasis in the body.
C1 [Chien, Yi-Hsuan; Yu, Yu-Hsiang; Chen, Yue-Wen] Natl Ilan Univ, Dept Biotechnol & Anim Sci, Yilan, Taiwan.
   [Chien, Yi-Hsuan; Yu, Yu-Hsiang; Chen, Yue-Wen] Natl Ilan Univ, Res Ctr Honey Bee & Bee Prod, Yilan, Taiwan.
C3 National Ilan University; National Ilan University
RP Yu, YH; Chen, YW (corresponding author), Natl Ilan Univ, Dept Biotechnol & Anim Sci, Yilan, Taiwan.; Yu, YH; Chen, YW (corresponding author), Natl Ilan Univ, Res Ctr Honey Bee & Bee Prod, Yilan, Taiwan.
EM yuyh@niu.edu.tw; chenyw@niu.edu.tw
RI Yu, Yu-Hsiang/J-4424-2019
OI Yu, Yu-Hsiang/0000-0001-9629-8478
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NR 68
TC 13
Z9 13
U1 2
U2 33
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD APR
PY 2023
VL 160
AR 114386
DI 10.1016/j.biopha.2023.114386
EA FEB 2023
PG 14
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA 9Q8CE
UT WOS:000945184500001
PM 36773526
OA gold
DA 2025-06-11
ER

PT J
AU Devrajani, T
   Abid, S
   Shaikh, H
   Shaikh, I
   Devrajani, DB
   Memon, SM
   Waryah, AM
   Ujjan, ID
   Syed, BM
AF Devrajani, Tarachand
   Abid, Shariq
   Shaikh, Hina
   Shaikh, Iram
   Devrajani, Durshana Bai
   Memon, Sikander Munir
   Waryah, Ali Muhammad
   Ujjan, Ikram Din
   Syed, Binafsha Manzoor
TI Relationship between aging and control of metabolic syndrome with
   telomere shortening: a cross-sectional study
SO SCIENTIFIC REPORTS
LA English
DT Article
ID NUTRITION EXAMINATION SURVEY; SOCIOECONOMIC-STATUS; NATIONAL-HEALTH;
   LENGTH; ASSOCIATION; MORTALITY; P73
AB Aging is considered one of the major risk factors for several human disorders. The telomere plays a crucial role in regulating cellular responsiveness to stress and growth stimuli as well as maintaining the integrity of the Deoxyribonucleic Acid (DNA), and aging leads to the progressive decline in the telomere length (TL) due to continuous cell division. The aim of this study was to determine the relationship between TL and advancing age and the impact of metabolic syndrome (MetS) on TL. Firstly, we determined the association of advancing age and TL, by measuring telomere length (T/S ratio) in healthy volunteers (n = 90). The TL was compared between normal population and patients with metabolic syndrome (n = 298). The age matched controlled and uncontrolled MetS patients (n = 149) were also compared for their TL T/S ratio. The TL showed negative correlation with advancing age, whereas the significant change was observed at the cut-offs of 40 and 70 years defining 40 with longer TL and 70 as shorter TL. The longest T/S ratio at 2.46 was measured at the age range of 1 year in healthy volunteers, while elderly population showed considerably shorter TL. The patients older than 60 years with poor or uncontrolled MetS had shorter TL, as compared to the controlled MetS. In conclusion our findings suggest that TL was negatively correlated with advancing age. Uncontrolled metabolic syndrome appeared to have worsening effects on TL. Telomere length appears to have potential to be used a parameter to determine age. However, further large scale studies are recommended to make firm guidelines.
C1 [Devrajani, Tarachand; Abid, Shariq; Memon, Sikander Munir; Syed, Binafsha Manzoor] Liaquat Univ Med & Hlth Sci, Med Res Ctr, Clin Res Div, Jamshoro, Pakistan.
   [Devrajani, Tarachand] Liaquat Univ Med & Hlth Sci, Dept Med, Jamshoro, Pakistan.
   [Shaikh, Hina; Shaikh, Iram; Devrajani, Durshana Bai; Waryah, Ali Muhammad] Liaquat Univ Med & Hlth Sci, Med Res Ctr, Dept Mol Biol & Genet, Jamshoro, Pakistan.
   [Ujjan, Ikram Din] Liaquat Univ Med & Hlth Sci, Dept Pathol, Jamshoro, Pakistan.
C3 Liaquat University of Medical & Health Sciences; Liaquat University of
   Medical & Health Sciences; Liaquat University of Medical & Health
   Sciences; Liaquat University of Medical & Health Sciences
RP Syed, BM (corresponding author), Liaquat Univ Med & Hlth Sci, Med Res Ctr, Clin Res Div, Jamshoro, Pakistan.
EM binafsha.syed@lumhs.edu.pk
RI Syed, Binafsha/AAC-6670-2020; Waryah, Ali/A-5003-2018; Memon,
   Sikander/N-6764-2016
OI Memon, Sikander/0000-0001-9682-3527
FU Staff of Medical Research Center, laboratory of Molecular Biology and
   Genetics for providing experimentation support and platform; and Vice
   Chancellor office for administrative support.
FX Staff of Medical Research Center, laboratory of Molecular Biology and
   Genetics for providing experimentation support and platform; and Vice
   Chancellor office for administrative support.
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NR 31
TC 7
Z9 7
U1 0
U2 1
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD OCT 19
PY 2023
VL 13
IS 1
AR 17878
DI 10.1038/s41598-023-44715-1
PG 8
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA U7SK9
UT WOS:001086765500027
PM 37857729
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Iacob, SA
   Iacob, DG
AF Iacob, Simona Alexandra
   Iacob, Diana Gabriela
TI Non-Alcoholic Fatty Liver Disease in HIV/HBV Patients - a Metabolic
   Imbalance Aggravated by Antiretroviral Therapy and Perpetuated by the
   Hepatokine/Adipokine Axis Breakdown
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Review
DE non-alcoholic fatty liver disease; hepatitis B virus; HIV; hepatokines;
   adipokines; oxidative stress; metabolic syndrome; antiretroviral
   treatment
ID GROWTH-FACTOR 21; NF-KAPPA-B; CHRONIC HEPATITIS-B; VIRUS-INFECTED
   PATIENTS; MESSENGER-RNA EXPRESSION; MORBIDLY OBESE-PATIENTS; SERUM
   ADIPOKINE LEVELS; INSULIN-RESISTANCE; FETUIN-A; HEPATOCELLULAR-CARCINOMA
AB Non-alcoholic fatty liver disease (NAFLD) is strongly associated with the metabolic syndrome and is one of the most prevalent comorbidities in HIV and HBV infected patients. HIV plays an early and direct role in the development of metabolic syndrome by disrupting the mechanism of adipogenesis and synthesis of adipokines. Adipokines, molecules that regulate the lipid metabolism, also contribute to the progression of NAFLD either directly or via hepatic organokines (hepatokines). Most hepatokines play a direct role in lipid homeostasis and liver inflammation but their role in the evolution of NAFLD is not well defined. The role of HBV in the pathogenesis of NAFLD is controversial. HBV has been previously associated with a decreased level of triglycerides and with a protective role against the development of steatosis and metabolic syndrome. At the same time HBV displays a high fibrogenetic and oncogenetic potential. In the HIV/HBV co-infection, the metabolic changes are initiated by mitochondrial dysfunction as well as by the fatty overload of the liver, two interconnected mechanisms. The evolution of NAFLD is further perpetuated by the inflammatory response to these viral agents and by the variable toxicity of the antiretroviral therapy. The current article discusses the pathogenic changes and the contribution of the hepatokine/adipokine axis in the development of NAFLD as well as the implications of HIV and HBV infection in the breakdown of the hepatokine/adipokine axis and NAFLD progression.
C1 [Iacob, Simona Alexandra; Iacob, Diana Gabriela] Carol Davila Univ Med & Pharm, Dept Infect Dis, Bucharest, Romania.
   [Iacob, Simona Alexandra] Natl Inst Infect Dis Prof Dr Matei Bals, Dept Infect Dis, Bucharest, Romania.
   [Iacob, Diana Gabriela] Emergency Univ Hosp, Dept Infect Dis, Bucharest, Romania.
C3 Carol Davila University of Medicine & Pharmacy; National Institute for
   Infectious Diseases "Matei Bals"; National Institute for Infectious
   Diseases "Matei Bals"; National Institute for Infectious Diseases "Matei
   Bals"
RP Iacob, DG (corresponding author), Carol Davila Univ Med & Pharm, Dept Infect Dis, Bucharest, Romania.; Iacob, DG (corresponding author), Emergency Univ Hosp, Dept Infect Dis, Bucharest, Romania.
EM dianagiacob@gmail.com
RI iacob, simona/ABF-7087-2020; Iacob, Diana/ABB-8424-2020
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NR 315
TC 13
Z9 13
U1 1
U2 14
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD MAR 9
PY 2022
VL 13
AR 814209
DI 10.3389/fendo.2022.814209
PG 21
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 0G3EY
UT WOS:000777932600001
PM 35355551
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Zilioli, S
   Gómez, JM
   Jiang, YP
   Rodriguez-Stanley, J
AF Zilioli, Samuele
   Gomez, Jennifer M.
   Jiang, Yanping
   Rodriguez-Stanley, Jacqueline
TI Childhood Socioeconomic Status and Cardiometabolic Health: A Test of the
   John Henryism Hypothesis in African American Older Adults
SO JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL
   SCIENCES
LA English
DT Article
DE Childhood SES; John Henryism; Metabolic syndrome; Systemic inflammation
ID BLOOD-PRESSURE; METABOLIC SYNDROME; CARDIOVASCULAR-DISEASE; RACIAL
   DISPARITIES; LIFE-SPAN; STRESS; EDUCATION; RISK; SUSCEPTIBILITY;
   HYPERTENSION
AB Background John Henryism (JH) is a form of active high-effort coping. Low-socioeconomic status (SES) African Americans adopting JH to deal with structural racism and other chronic stressors might be more likely to display cardiovascular disease risk factors. Previous tests of this hypothesis have mostly focused on the moderating role of current SES and hypertension as the outcome variable. Furthermore, most of the previous work has been conducted among young and middle-aged adults. This study aimed at extending work on the JH hypothesis by testing the combined effect of JH and childhood SES on metabolic syndrome and systemic inflammation among African American older adults. Methods One hundred seventy urban African American older adults (M-age = 67.64 years, 75.9% female) were recruited. Participants completed questionnaires assessing JH, childhood SES, and other variables used as covariates (ie, demographic information, chronic conditions, medication use, and health behaviors). Blood pressure, waist circumference, and blood were also collected. Triglycerides, high-density lipoprotein cholesterol, hemoglobin A1C, and C-reactive protein levels were measured from the blood samples. Results JH was positively associated with metabolic syndrome symptoms among participants reporting low childhood SES levels, but not among those reporting high childhood SES levels. The same pattern did not emerge when we considered current SES. Similar patterns of results did not emerge as far as systemic inflammation was concerned. Conclusions Our findings highlight the importance of considering the joint impact of objective conditions early in life and individual psychological proclivities in explaining increased risk for cardiovascular disease risk in this population.
C1 [Zilioli, Samuele; Gomez, Jennifer M.; Rodriguez-Stanley, Jacqueline] Wayne State Univ, Dept Psychol, 5057 Woodward Ave, Detroit, MI 48202 USA.
   [Zilioli, Samuele] Wayne State Univ, Dept Family Med & Publ Hlth Sci, Detroit, MI 48202 USA.
   [Gomez, Jennifer M.] Ctr Inst Courage, Palo Alto, CA USA.
   [Jiang, Yanping] Rutgers State Univ, Inst Hlth Hlth Care Policy & Aging Res, New Brunswick, NJ USA.
   [Jiang, Yanping] Rutgers State Univ, Dept Family Med & Community Hlth, New Brunswick, NJ USA.
C3 Wayne State University; Wayne State University; Rutgers University
   System; Rutgers University New Brunswick; Rutgers University System;
   Rutgers University New Brunswick
RP Zilioli, S (corresponding author), Wayne State Univ, Dept Psychol, 5057 Woodward Ave, Detroit, MI 48202 USA.
EM fv0808@wayne.edu
RI Jiang, Yanping/ABC-6916-2021; Gomez, Jennifer/KJM-1479-2024
OI Jiang, Yanping/0000-0002-0931-9507; Zilioli,
   Samuele/0000-0002-1126-8913; Rodriguez-Stanley,
   Jacqueline/0000-0003-0422-9438
FU National Institutes of Health [P30 AG015281]; Michigan Center for Urban
   African American Aging Research (MCUAAAR); Faculty Competition for
   Postdoctoral Fellowship from Wayne State University; National Institute
   on Aging [P30AG015281] Funding Source: NIH RePORTER
FX This study was supported by a grant from the National Institutes of
   Health (P30 AG015281) and the Michigan Center for Urban African American
   Aging Research (MCUAAAR). The preparation of the manuscript was partly
   supported by a Faculty Competition for Postdoctoral Fellowship from
   Wayne State University (Samuele Zilioli).
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NR 57
TC 5
Z9 7
U1 0
U2 2
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1079-5006
EI 1758-535X
J9 J GERONTOL A-BIOL
JI J. Gerontol. Ser. A-Biol. Sci. Med. Sci.
PD FEB 3
PY 2022
VL 77
IS 2
BP E56
EP E64
DI 10.1093/gerona/glab280
EA OCT 2021
PG 9
WC Geriatrics & Gerontology; Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA YZ0YU
UT WOS:000755209900003
PM 34569595
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Kojadinovic, MI
   Arsic, AC
   Debeljak-Martacic, JD
   Konic-Ristic, AI
   Kardum, ND
   Popovic, TB
   Glibetic, MD
AF Kojadinovic, Milica I.
   Arsic, Aleksandra C.
   Debeljak-Martacic, Jasmina D.
   Konic-Ristic, Aleksandra I.
   Kardum, Nevena Dj
   Popovic, Tamara B.
   Glibetic, Marija D.
TI Consumption of pomegranate juice decreases blood lipid peroxidation and
   levels of arachidonic acid in women with metabolic syndrome
SO JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
LA English
DT Article
DE metabolic syndrome; pomegranate juice; fatty acid; arachidonic acid;
   lipid peroxidation
ID ESTIMATED DESATURASE ACTIVITIES; RADICAL-SCAVENGING ACTIVITY; OXIDATIVE
   STRESS; ANTIOXIDANT ACTIVITY; FATTY-ACIDS; DIABETIC-PATIENTS; ELLAGIC
   ACID; RISK; OBESITY; MEN
AB BACKGROUNDPomegranate juice is a rich source of polyphenols and is thus a promising dietary antioxidant with numerous health-promoting effects. These include a beneficial impact on cardiovascular health that could be partly attributed to the effects of polyphenols on lipid metabolism. The aim of this study was to investigate whether consumption of pomegranate juice for 6 weeks could modify lipid peroxidation and phospholipid fatty acid composition of plasma and erythrocytes in subjects with metabolic syndrome. Twenty-three women, aged 40-60 years, were enrolled and randomly assigned into two groups: the intervention group, in which each participant consumed 300 mL of juice per day for 6 weeks; and a control group.
   RESULTSA statistically significant decrease in the relative amount of arachidonic acid (P < 0.05) and an increase in the relative amount of saturated fatty acids (P < 0.05) were observed in the intervention group at the end of the consumption period. In addition, pomegranate juice significantly increased the relative amount of total mono-unsaturated fatty acids (P < 0.05), and significantly decreased the levels of thiobarbituric acid reactive substances in erythrocytes (P < 0.05). The status of blood lipids and the values for blood pressure were not changed during the study.
   CONCLUSIONThe results obtained indicate a positive impact of the consumption of pomegranate juice on lipid peroxidation and fatty acid status in subjects with metabolic syndrome and suggest potential anti-inflammatory and cardio-protective effects. (c) 2016 Society of Chemical Industry
C1 [Kojadinovic, Milica I.; Arsic, Aleksandra C.; Debeljak-Martacic, Jasmina D.; Konic-Ristic, Aleksandra I.; Kardum, Nevena Dj; Popovic, Tamara B.; Glibetic, Marija D.] Univ Belgrade, Inst Med Res, Ctr Res Excellence Nutr & Metab, Tadeusa Koscuska 1, Belgrade 11129, Serbia.
C3 University of Belgrade
RP Kojadinovic, MI (corresponding author), Univ Belgrade, Inst Med Res, Ctr Res Excellence Nutr & Metab, Tadeusa Koscuska 1, Belgrade 11129, Serbia.
EM aristokratija@yahoo.com
RI Vidovic, Nevena/AFT-1529-2022; Konic Ristic, Aleksandra/KDM-9154-2024;
   Konic Ristic, Aleksandra/D-7634-2014
OI Arsic, Aleksandra/0000-0001-8498-9415; Konic Ristic,
   Aleksandra/0000-0002-1218-1190; Debeljak Martacic,
   Jasmina/0000-0002-9605-3793; Kardum Vidovic, Nevena/0000-0001-6931-3695
FU Ministry of Science of the Republic of Serbia [41030]
FX This work was supported by Project 41030 financed by the Ministry of
   Science of the Republic of Serbia.
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NR 59
TC 54
Z9 59
U1 1
U2 22
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-5142
EI 1097-0010
J9 J SCI FOOD AGR
JI J. Sci. Food Agric.
PD APR
PY 2017
VL 97
IS 6
BP 1798
EP 1804
DI 10.1002/jsfa.7977
PG 7
WC Agriculture, Multidisciplinary; Chemistry, Applied; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture; Chemistry; Food Science & Technology
GA EP7RP
UT WOS:000397575200016
PM 27476699
DA 2025-06-11
ER

PT J
AU Vafaeipour, Z
   Razavi, BM
   Hosseinzadeh, H
AF Vafaeipour, Zeinab
   Razavi, Bibi Marjan
   Hosseinzadeh, Hossein
TI Effects of turmeric (Curcuma longa) and its constituent (curcumin) on
   the metabolic syndrome: An updated review
SO JOURNAL OF INTEGRATIVE MEDICINE-JIM
LA English
DT Review
DE Turmeric; Curcuma longa; Curcumin; Metabolic syndrome; Diabetes;
   Hyperlipidemia
ID TYPE-2 DIABETES-MELLITUS; FATTY LIVER-DISEASE; RANDOMIZED
   CONTROLLED-TRIAL; INDUCED LIPID-ACCUMULATION; OXIDATIVE STRESS;
   DOUBLE-BLIND; ENDOTHELIAL DYSFUNCTION; INSULIN-RESISTANCE; MOLECULAR
   TARGETS; ACTIVE PRINCIPLE
AB Metabolic syndrome (MS) involves people with the following risk factors: obesity, hypertension, high glucose level and hyperlipidemia. It can increase the risk of heart disease, stroke and type 2 diabetes mellitus. The prevalence of MS in the world's adult population is about 20%-25%. Today, there is much care to use medicinal plants. Turmeric (Curcuma longa) as well as curcumin which is derived from the rhizome of the plant, has been shown beneficial effects on different components of MS. Thus, the purpose of this manuscript was to introduce different in vitro, in vivo and human studies regarding the effect of turmeric and its constituent on MS. Moreover, different mechanisms of action by which this plant overcomes MS have been introduced. Based on studies, turmeric and its bioactive component, curcumin, due to their anti-inflammatory and antioxidant properties, have antidiabetic effects through increasing insulin release, antihyperlipidemic effects by increasing fatty acid uptake, anti-obesity effects by decreasing lipogenesis, and antihypertensive effects by increasing nitric oxide. According to several in vivo, in vitro and human studies, it can be concluded that turmeric or curcumin has important values as a complementary therapy in MS. However, more clinical trials should be done to confirm these effects.
   Please cite this article as: Vafaeipour Z, Razavi BM, Hosseinzadeh H. Effects of turmeric (Curcuma longa) and its constituent (curcumin) on the metabolic syndrome: An updated review. J Integr Med. 2022; 20(3): 193-203. (c) 2022 Shanghai Yueyang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine. Published by Elsevier B.V. All rights reserved.
C1 [Vafaeipour, Zeinab] Mashhad Univ Med Sci, Student Res Comm, Mashhad 9177948954, Razavi Khorasan, Iran.
   [Vafaeipour, Zeinab; Razavi, Bibi Marjan; Hosseinzadeh, Hossein] Mashhad Univ Med Sci, Sch Pharm, Dept Pharmacodynam & Toxicol, Mashhad 9177948954, Razavi Khorasan, Iran.
   [Razavi, Bibi Marjan] Mashhad Univ Med Sci, Targeted Drug Delivery Res Ctr, Pharmaceut Technol Inst, Mashhad 9177948954, Razavi Khorasan, Iran.
   [Hosseinzadeh, Hossein] Mashhad Univ Med Sci, Pharmaceut Res Ctr, Pharmaceut Technol Inst, Mashhad 9177948954, Razavi Khorasan, Iran.
C3 Mashhad University of Medical Sciences; Mashhad University of Medical
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RP Hosseinzadeh, H (corresponding author), Mashhad Univ Med Sci, Pharmaceut Res Ctr, Pharmaceut Technol Inst, Mashhad 9177948954, Razavi Khorasan, Iran.
EM hosseinzadehh@mums.ac.ir
RI Razavi, Bibi/AAY-5636-2020; Hosseinzadeh, Hossein/F-3013-2010
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NR 148
TC 32
Z9 36
U1 6
U2 21
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2095-4964
J9 J INTEGR MED-JIM
JI J. Integr. Med.-JIM
PD MAY
PY 2022
VL 20
IS 3
BP 193
EP 203
DI 10.1016/j.joim.2022.02.008
PG 11
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA 7U0CV
UT WOS:000911807200002
PM 35292209
DA 2025-06-11
ER

PT J
AU Jang, I
   Kim, JS
   Kim, M
   Lee, E
AF Jang, Insil
   Kim, Ji-Su
   Kim, Minhae
   Lee, Eunkyung
TI Assessing Information Needs Regarding Metabolic Syndrome Among
   Gynecological Cancer Survivors A Concurrent Mixed Method
SO CANCER NURSING
LA English
DT Article
DE Cancer survivors; Gynecological cancer; Information need; Knowledge
   deficits; Metabolic syndrome; Survivorship
ID HEALTH BEHAVIOR-THEORY; KNOWLEDGE; BREAST; RISK; INTERVENTION;
   ASSOCIATION; PREVENTION; MANAGEMENT; AWARENESS; OBESITY
AB Background Cancer survivors have an increased risk of non-cancer-related deaths, particularly metabolic syndrome (MetS). Objective We aimed to assess knowledge deficits regarding metabolism-related diseases among gynecological cancer survivors and the preferred source of health information. Methods Using a mixed methods approach, 70 participants responded to a structured modified version of the MetS questionnaire. We conducted 28 semistructured interviews of gynecological cancer survivors with MetS. Responses were independently coded by 2 researchers, including MetS knowledge, behaviors for self-management, and preferred learning methods. Results Metabolic syndrome was diagnosed in 17% of the participants. More than 50% of the participants wanted to learn about MetS and requested a consultation with healthcare providers, 70% reported that they had heard of MetS, and 61.4% reported that they had MetS-related knowledge (correct answer rate by MetS-related component, similar to 50%). The level of MetS-related knowledge was poor in both the quantitative and qualitative data. Most of the participants defined MetS-related self-management health behaviors as regular eating and exercise in their own words. Participants mostly wanted exercise management (29% of the participants), followed by dietary life management (27.4%), stress management (17.4%), weight management (13.7%), definition and diagnostic methods of MetS (9.1%), and smoking and drinking management (3.3%). Participants wished to use a handbook in small groups or receive counseling by healthcare providers. Conclusion We observed poor awareness and knowledge level and the need for information regarding MetS among gynecological cancer surviv
C1 [Jang, Insil] Univ Ulsan, Dept Nursing, Ulsan, South Korea.
   [Kim, Ji-Su] Chung Ang Univ, Dept Nursing, 84 Heukseok Ro, Seoul, South Korea.
   [Kim, Minhae] Natl Canc Ctr, Dept Nursing, Goyang Si, Gyeonggi Do, South Korea.
   [Lee, Eunkyung] Kyung In Womens Univ, Dept Nursing, Incheon, South Korea.
C3 University of Ulsan; Chung Ang University; National Cancer Center -
   Korea (NCC)
RP Kim, JS (corresponding author), Chung Ang Univ, Dept Nursing, 84 Heukseok Ro, Seoul, South Korea.
EM jisu80@cau.ac.kr
RI Kim, Kyung/I-5501-2015; JANG, INSIL/AAS-2263-2020
OI Kim, Ji-Su/0000-0002-9512-1934
FU National Research Foundation of Korea [NRF-2015R1C1A1A02036408]
FX This study was funded by the National Research Foundation of Korea
   (NRF-2015R1C1A1A02036408).
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NR 42
TC 4
Z9 4
U1 0
U2 11
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0162-220X
EI 1538-9804
J9 CANCER NURS
JI Cancer Nurs.
PD MAR-APR
PY 2019
VL 42
IS 2
BP E48
EP E60
DI 10.1097/NCC.0000000000000598
PG 13
WC Oncology; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Oncology; Nursing
GA HN7VG
UT WOS:000460400000006
PM 29734256
DA 2025-06-11
ER

PT J
AU Donatelli, F
   Cavagna, P
   Di Dedda, G
   Catenacci, A
   Di Nicola, M
   Lorini, L
   Fumagalli, R
   Carli, F
AF Donatelli, F.
   Cavagna, P.
   Di Dedda, G.
   Catenacci, A.
   Di Nicola, M.
   Lorini, L.
   Fumagalli, R.
   Carli, F.
TI Correlation between pre-operative metabolic syndrome and persistent
   blood glucose elevation during cardiac surgery in non-diabetic patients
SO ACTA ANAESTHESIOLOGICA SCANDINAVICA
LA English
DT Article
DE metabolic syndrome; cardiopulmonary bypass
ID HOMEOSTASIS MODEL ASSESSMENT; INTENSIVE INSULIN THERAPY; CARDIOPULMONARY
   BYPASS; DIABETIC-PATIENTS; GLYCEMIC CONTROL; RESISTANCE; REMIFENTANIL;
   INFLAMMATION; RESPONSES; STRESS
AB Background: Cardiopulmonary-bypass (CPB) induces hyperglycemia. There is growing evidence that perioperative maintenance of blood glucose within the physiological range improves patients' outcome. Nevertheless, perioperative normoglycemia is often difficult to achieve during surgery with CPB and the response to insulin infusion is characterized by a considerable variability. The aim of this study was to determine to what extent the presence of pre-operative metabolic syndrome (MS) influences the blood glucose and insulin response during cardiac surgery.
   Methods: Forty-five patients scheduled for elective cardiac surgery were screened for the presence of MS according to the International Diabetes Federation definition. Patients were then assigned to two groups: those with metabolic syndrome (MSP) and those without (control). During surgery, blood glucose levels were measured in all patients and hyperglycemia was treated with a standard protocol of continuous insulin infusion.
   Results: The mean blood glucose levels during CPB increased only in the MSP group (P < 0.001). Mean blood glucose in control patients did not increase during CPB (P = 0.4). Patients with MS received 13.3 +/- 8.4 IU of insulin during CPB, while the control group did not require insulin treatment (P < 0.001). Forty percent of patients in the control group and 100% of those in the MSP group developed post-operative insulin resistance. C-reactive protein was higher in the MSP group before, during and at 48 h after surgery.
   Conclusions: The mean blood glucose levels during CPB increased only in patients with MS, while they remained unchanged in patients in the control group.
C1 [Donatelli, F.; Cavagna, P.; Di Dedda, G.; Catenacci, A.; Di Nicola, M.; Lorini, L.] Osped Riuniti Bergamo, Dept Anesthesia, I-24100 Bergamo, Italy.
   [Di Nicola, M.] Univ G dAnnunzio, Dipartimento Stat, Chieti, Italy.
   [Fumagalli, R.] Univ Milan, Bicocca, Italy.
   [Carli, F.] McGill Univ, Dept Anesthesia, Montreal, PQ, Canada.
C3 Ospedali Riuniti di Bergamo; G d'Annunzio University of Chieti-Pescara;
   University of Milan; McGill University
RP Donatelli, F (corresponding author), Osped Riuniti Bergamo, Dept Anesthesia, Largo Barozzi 3, I-24100 Bergamo, Italy.
EM fdonatelli@inwind.it
RI Donatelli, Francesco/G-9311-2012; Fumagalli, Roberto/AAB-9746-2019; Di
   Nicola, Marco/HKP-2003-2023
OI lorini, luca ferdinando/0000-0002-2711-3377; FUMAGALLI,
   ROBERTO/0000-0003-0398-1329; DI NICOLA, MARTA/0000-0003-1748-1931
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NR 35
TC 22
Z9 25
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0001-5172
EI 1399-6576
J9 ACTA ANAESTH SCAND
JI Acta Anaesthesiol. Scand.
PD SEP
PY 2008
VL 52
IS 8
BP 1103
EP 1110
DI 10.1111/j.1399-6576.2008.01693.x
PG 8
WC Anesthesiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Anesthesiology
GA 339QX
UT WOS:000258593200012
PM 18840111
DA 2025-06-11
ER

PT J
AU Wang, J
   Wu, DC
   Guo, H
   Li, MX
AF Wang, Juan
   Wu, Daichao
   Guo, Hui
   Li, Meixiang
TI Hyperandrogenemia and insulin resistance: The chief culprit of
   polycystic ovary syndrome
SO LIFE SCIENCES
LA English
DT Review
DE PCOS; Hyperandrogenemia; Insulin resistance; Advanced glycosylation end
   products; Endocrine disrupting chemicals
ID GRANULOSA-CELLS; SYNDROME PCOS; DEHYDROEPIANDROSTERONE-SULFATE;
   METABOLIC SYNDROME; GENETIC-VARIATION; OXIDATIVE STRESS; WOMEN;
   EXPRESSION; ADIPONECTIN; ANDROGEN
AB Polycystic ovary syndrome (PCOS) is one of the most common systemic reproductive endocrine diseases, which has a variety of effects on a woman's health. Because of the involvement of multiple pathways and the lack of common clues, PCOS demonstrates multifactorial properties and heterogeneity of symptoms. Recent studies have demonstrated that the core etiology and primary endocrine characteristics of PCOS are hyperandrogenemia (HA) and insulin resistance (IR). HA and IR are the main causes of PCOS and they can interplay each other in the occurrence and development of PCOS. Just because of this, the study about the effects of HA and IR on pathophysiology of various related symptoms of PCOS is very important to understand the pathogenesis of PCOS. This paper reviews the main symptoms of PCOS, including neuroendocrine disorders, reproductive processes, dyslipidemia, obesity, hypertension, nonalcoholic fatty liver disease (NAFLD), and sleep disordered breathing, which seriously affect the physical and mental health of PCOS women. The increasing knowledge of the development pattern of HA and IR in PCOS suggests that changes in diet and lifestyle, and the discovery of potential therapeutic agents may improve PCOS. However, further studies are needed to clarify the mutual influence and relation of HA and IR in development of PCOS. This review provides an overview of the current knowledge about the effects of HA and IR on PCOS.
C1 [Wang, Juan; Wu, Daichao; Guo, Hui; Li, Meixiang] Univ South China, Inst Clin Anat & Reprod Med, Dept Histol & Embryol, 28 West Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.
C3 University of South China
RP Li, MX (corresponding author), Univ South China, Inst Clin Anat & Reprod Med, Dept Histol & Embryol, 28 West Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.
EM 430000146116@usc.edu.cn
RI li, liangwei/JGM-2459-2023
FU Department of Science and Technology of Hunan province and Hengyang
FX We wish to thank the Department of Science and Technology of Hunan
   province and Hengyang for their partial financial support of this study.
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NR 113
TC 203
Z9 223
U1 2
U2 45
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0024-3205
EI 1879-0631
J9 LIFE SCI
JI Life Sci.
PD NOV 1
PY 2019
VL 236
AR 116940
DI 10.1016/j.lfs.2019.116940
PG 9
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA JG8TF
UT WOS:000492349800010
PM 31604107
DA 2025-06-11
ER

PT J
AU Scoville, DK
   Li, CYF
   Wang, DF
   Dempsey, JL
   Raftery, D
   Mani, S
   Gu, HW
   Cui, JLY
AF Scoville, David K.
   Li, Cindy Yanfei
   Wang, Dongfang
   Dempsey, Joseph L.
   Raftery, Daniel
   Mani, Sridhar
   Gu, Haiwei
   Cui, Julia Yue
TI Polybrominated Diphenyl Ethers and Gut Microbiome Modulate Metabolic
   Syndrome-Related Aqueous Metabolites in Mice
SO DRUG METABOLISM AND DISPOSITION
LA English
DT Article
ID PERSISTENT ORGANIC POLLUTANTS; PREGNANE-X-RECEPTOR; COLORECTAL-CANCER;
   FLAME-RETARDANTS; DIABETES-MELLITUS; OXIDATIVE STRESS; AMINO-ACIDS;
   OH-PBDES; SERUM; INFLAMMATION
AB Polybrominated diphenyl ethers (PBDEs) are persistent environmental toxicants associated with increased risk for metabolic syndrome. Intermediary metabolism is influenced by the intestinal microbiome. To test the hypothesis that PBDEs reduce host-beneficial intermediary metabolites in an intestinal microbiome-dependent manner, 9-week old male conventional (CV) and germ-free (GF) C57BU6 mice were orally gavaged once daily with vehicle, BDE-47, or BDE-99 (100 mu mol/kg) for 4 days. Intestinal microbiome (16S rDNA sequencing), liver transcriptome (RNA-Seq), and intermediary metabolites in serum, liver, as well as small and large intestinal contents (SIC and LIC; LC-MS) were examined. Changes in intermediary metabolite abundances in serum, liver, and SIC, were observed under basal conditions (CV vs. GF mice) and by PBDE exposure. PBDEs altered the largest number of metabolites in the LIC; most were regulated by PBDEs in GF conditions. Importantly, intestinal microbiome was necessary for PBDE-mediated decreases in branched-chain and aromatic amino acid metabolites, including 3-indolepropionic acid, a tryptophan metabolite recently shown to be protective against inflammation and diabetes. Gene-metabolite networks revealed a positive association between the hepatic glycan synthesis gene alpha-1,6-mannosyltransferase (A1g12) mRNA and mannose, which are important for protein glycosylation. Glycome changes have been observed in patients with metabolic syndrome. In LIC of CV mice, 23 bacterial taxa were regulated by PBDEs. Correlations of certain taxa with distinct serum metabolites further highlight a modulatory role of the microbiome in mediating PBDE effects. In summary, PBDEs impact intermediary metabolism in an intestinal microbiome-dependent manner, suggesting that dysbiosis may contribute to PBDE-mediated toxicities that include metabolic syndrome.
C1 [Scoville, David K.; Li, Cindy Yanfei; Dempsey, Joseph L.; Cui, Julia Yue] Univ Washington, Dept Environm & Occupat Hlth Sci, 4225 Roosevelt Way NE, Seattle, WA 98105 USA.
   [Wang, Dongfang; Raftery, Daniel] Univ Washington, Northwest Metabol Res Ctr, Dept Anesthesiol & Pain Med, Seattle, WA 98105 USA.
   [Wang, Dongfang] Peking Univ, Sch Publ Hlth, Dept Lab Sci & Technol, Beijing, Peoples R China.
   [Mani, Sridhar] Albert Einstein Coll Med, Bronx, NY 10467 USA.
   [Gu, Haiwei] Arizona State Univ, Coll Hlth Solut, Sch Nutr & Hlth Promot, Arizona Metabol Lab, Phoenix, AZ 85004 USA.
C3 University of Washington; University of Washington Seattle; University
   of Washington; University of Washington Seattle; Peking University;
   Yeshiva University; Montefiore Medical Center; Albert Einstein College
   of Medicine; Arizona State University; Arizona State University-Downtown
   Phoenix
RP Cui, JLY (corresponding author), Univ Washington, Dept Environm & Occupat Hlth Sci, 4225 Roosevelt Way NE, Seattle, WA 98105 USA.; Gu, HW (corresponding author), Arizona State Univ, Coll Hlth Solut, Sch Nutr & Hlth Promot, Arizona Metabol Lab, Phoenix, AZ 85004 USA.
EM haiweigu@asu.edu; juliacui@uw.edu
FU National Institutes of Health [R01 GM111381, R01 ES030197, R01
   ES025708]; University of Washington Center for Exposures, Diseases,
   Genomics, and Environment [P30 ES0007033]; Sheldon Murphy Endowment
FX This work was supported by the National Institutes of Health [Grants R01
   GM111381, R01 ES030197, R01 ES025708], the University of Washington
   Center for Exposures, Diseases, Genomics, and Environment [P30
   ES0007033], and the Sheldon Murphy Endowment.
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NR 94
TC 36
Z9 43
U1 1
U2 37
PU AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3995 USA
SN 0090-9556
EI 1521-009X
J9 DRUG METAB DISPOS
JI Drug Metab. Dispos.
PD AUG 1
PY 2019
VL 47
IS 8
BP 928
EP 940
DI 10.1124/dmd.119.086538
PG 13
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA IQ0JV
UT WOS:000480438000011
PM 31123037
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Nagase, M
AF Nagase, Miki
TI Activation of the aldosterone/mineralocorticoid receptor system in
   chronic kidney disease and metabolic syndrome
SO CLINICAL AND EXPERIMENTAL NEPHROLOGY
LA English
DT Article; Proceedings Paper
CT 52nd Annual Scientific Meeting of the Japanese-Society-of-Nephrology
CY JUN 03-05, 2009
CL Yokohama, JAPAN
SP Japanese Soc Nephrol
DE Proteinuria; Podocyte injury; Salt; Aldosterone-releasing factors; Rac1
ID HUMAN MINERALOCORTICOID RECEPTOR; HYPERTENSIVE-RATS; PRIMARY
   ALDOSTERONISM; DIABETIC-NEPHROPATHY; PLASMA-ALDOSTERONE; RENAL-DISEASE;
   MYOCARDIAL-INFARCTION; GLOMERULAR INJURY; ESTROGEN-RECEPTOR; TYPE-2
   DIABETES/
AB Recent clinical and experimental studies have shown that aldosterone is a potent inducer of proteinuria and that mineralocorticoid receptor (MR) antagonists confer efficient antiproteinuric effects. We identified glomerular epithelial cells (podocytes) as novel targets of aldosterone; activation of MR injures podocytes possibly via oxidative stress, resulting in disruption of glomerular filtration barrier, proteinuria, and progression of chronic kidney disease. We also demonstrated that SHR/cp, a rat model of metabolic syndrome, was susceptible to podocyte injury and proteinuria. Aldosterone excess caused by adipocyte-derived aldosterone-releasing factors was suggested to underlie the nephropathy. High salt intake augmented MR activation in the kidney and exacerbated the nephropathy. Furthermore, we identified an alternative pathway of MR activation by small GTPase Rac1. RhoGDI alpha knockout mice, a model with Rac1 activation in the kidney, showed albuminuria, podocyte injury, and glomerulosclerosis. Renal injury in the knockout mice was accompanied by enhanced MR signaling in the kidney despite normoaldosteronemia, and was ameliorated by an MR antagonist, eplerenone. Moreover, Rac-specific inhibitor significantly reduced the nephropathy, concomitantly with repression of MR activation. In vitro transfection studies provided direct evidence of Rac1-mediated MR activation. In conclusion, our findings suggest that MR activation plays a pivotal role in the pathogenesis of chronic kidney disease in metabolic syndrome, and that MR may be activated both aldosterone dependently (via aldosterone-releasing factors) and independently (via Rac1). MR antagonists are promising antiproteinuric drugs in metabolic syndrome, although long-term effects on renal outcomes, mortality, and safety need to be established.
C1 Univ Tokyo, Grad Sch Med, Dept Nephrol & Endocrinol, Div Chron Kidney Dis,Bunkyo Ku, Tokyo 1138655, Japan.
C3 University of Tokyo
RP Nagase, M (corresponding author), Univ Tokyo, Grad Sch Med, Dept Nephrol & Endocrinol, Div Chron Kidney Dis,Bunkyo Ku, 7-3-1 Hongo, Tokyo 1138655, Japan.
EM mnagase-tky@umin.ac.jp
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NR 89
TC 30
Z9 33
U1 0
U2 5
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1342-1751
J9 CLIN EXP NEPHROL
JI Clin. Exp. Nephrol.
PD AUG
PY 2010
VL 14
IS 4
BP 303
EP 314
DI 10.1007/s10157-010-0298-8
PG 12
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Urology & Nephrology
GA 634OZ
UT WOS:000280594100001
PM 20533072
DA 2025-06-11
ER

PT J
AU Bouvet, C
   de Chantemèle, EB
   Guihot, AL
   Vessières, E
   Bocquet, A
   Dumont, O
   Jardel, A
   Loufrani, L
   Moreau, P
   Henrion, D
AF Bouvet, Celine
   de Chantemele, Eric Belin
   Guihot, Anne-Laure
   Vessieres, Emilie
   Bocquet, Arnaud
   Dumont, Odile
   Jardel, Alain
   Loufrani, Laurent
   Moreau, Pierre
   Henrion, Daniel
TI Flow-induced remodeling in resistance arteries from obese Zucker rats is
   associated with endothelial dysfunction
SO HYPERTENSION
LA English
DT Article; Proceedings Paper
CT 6th International Workshop on Structure and Function of the Vascular
   System
CY FEB 01-03, 2007
CL Paris, FRANCE
DE resistance arteries; shear stress; NO; reactive oxygen species;
   mechanotransduction; obesity; metabolic syndrome
ID NITRIC-OXIDE; BLOOD-FLOW; MECHANICAL-BEHAVIOR; DEPENDENT DILATION;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; CAROTID-ARTERY; NO; ADAPTATION;
   PREVALENCE
AB Chronic increases in blood flow increase arterial diameter and NO-dependent dilation in resistance arteries. Because endothelial dysfunction accompanies metabolic syndrome, we hypothesized that flow- mediated remodeling might be impaired in obese rat resistance arteries. Obese and lean Zucker rat mesenteric resistance arteries were exposed to chronic flow increases through arterial ligation in vivo: arteries exposed to high flow were compared with normal flow arteries. Diameter was measured in vitro in cannulated arteries using pressure arteriography. After 7 days, outward remodeling ( diameter increased from 346 +/- 9 to 412 +/- 11 mu m at 100 mm Hg) occurred in lean high- flow arteries. Endothelium- dependent tone was reduced in high- flow arteries from obese rats by contrast with lean animals. On the other hand, diameter enlargement occurred similarly in the 2 strains. The involvement of NO in endothelium- dependent dilation ( evidenced by NO blockade) and endothelial NO synthase phosphorylation was smaller in obese than in lean rats. Superoxide anion and reduced nicotinamide- adenine dinucleotide phosphate oxidase subunit expression ( p67phox and gp91phox) increased in obese rats and were higher in high- flow than in control arteries. Acute Tempol ( a catalase mimetic), catalase plus superoxide dismutase, and L- arginine plus tetrahydrobiopterin restored endothelium- dependent dilation in obese rat normal and high- flow arteries to the level found in lean control arteries. Thus, flow- induced remodeling in obese resistance arteries was associated with a reduced endothelium- mediated dilation because of a decreased NO bioavailability and an excessive superoxide production. This dysfunction might have negative consequences in ischemic diseases in patients with obesity or metabolic syndrome.
C1 Univ Angers, UMR 6214, Dept Integrated Neurovasc Biol,CNRS, Inst Natl Sante & Rech 771,Fac Med, F-49045 Angers, France.
   Univ Montreal, Fac Pharm, Montreal, PQ H3C 3J7, Canada.
C3 Centre National de la Recherche Scientifique (CNRS); Universite
   d'Angers; Institut National de la Sante et de la Recherche Medicale
   (Inserm); Universite de Montreal
RP Henrion, D (corresponding author), Univ Angers, UMR 6214, Dept Integrated Neurovasc Biol,CNRS, Inst Natl Sante & Rech 771,Fac Med, F-49045 Angers, France.
EM daniel.henrion@univ-angers.fr
RI de Chantemele, Eric/H-8923-2019; Moreau, Pierre/JHU-2540-2023; Henrion,
   Daniel/N-7023-2015; loufrani, laurent/K-1713-2015; vessieres,
   emilie/K-1894-2015; Henrion, Daniel/J-8141-2015
OI Belin de Chantemele, Eric J./0000-0002-0184-3830; Henrion,
   Daniel/0000-0003-1094-0285; Moreau, Pierre/0000-0002-3604-721X
CR Alp NJ, 2004, ARTERIOSCL THROM VAS, V24, P413, DOI 10.1161/01.ATV.0000110785.96039.f6
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NR 30
TC 70
Z9 77
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0194-911X
EI 1524-4563
J9 HYPERTENSION
JI Hypertension
PD JUL
PY 2007
VL 50
IS 1
BP 248
EP 254
DI 10.1161/HYPERTENSIONAHA.107.088716
PG 7
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Cardiovascular System & Cardiology
GA 180XP
UT WOS:000247401600040
PM 17515452
DA 2025-06-11
ER

PT J
AU Bordoni, A
   Boesch, C
   Malpuech-Brugère, C
   Orfila, C
   Tomás-Cobos, L
AF Bordoni, A.
   Boesch, C.
   Malpuech-Brugere, C.
   Orfila, C.
   Tomas-Cobos, L.
TI The role of bioactives in energy metabolism and metabolic syndrome
SO PROCEEDINGS OF THE NUTRITION SOCIETY
LA English
DT Article; Proceedings Paper
CT Summer Meeting of the Nutrition-Society / Conference on Getting Energy
   Balance Right / Symposium 3 on Dietary Factors in Energy Metabolism
CY JUL 10-12, 2018
CL Univ Leeds, Leeds, ENGLAND
SP Nutr Soc
HO Univ Leeds
DE Anthocyanins; beta-glucan; Catechins; n-3 long chain PUFA; Metabolic
   syndrome
ID POLYUNSATURATED FATTY-ACIDS; OAT BETA-GLUCAN; RANDOMIZED
   CONTROLLED-TRIAL; POSTPRANDIAL BLOOD-GLUCOSE; SYNDROME RISK-FACTORS;
   WHOLE-GRAIN INTAKE; INSULIN-RESISTANCE; DIETARY SUPPLEMENTATION;
   OXIDATIVE STRESS; TEA CONSUMPTION
AB Some food bioactives potentially exert anti-obesity effects. Anthocyanins (ACN), catechins, beta-glucan (BG) and n-3 long chain PUFA (LCPUFA) are among the most promising candidates and have been considered as a strategy for the development of functional foods counteracting body weight gain. At present, clinical trials, reviews and meta-analyses addressing anti-obesity effects of various bioactives or bioactive-rich foods show contradictory results. Abdominal obesity is an important criterion for metabolic syndrome (MetS) diagnosis along with glucose intolerance, dyslipidaemia and hypertension. Food bioactives are supposed to exert beneficial effects on these parameters, therefore representing alternative therapy approaches for the treatment of MetS. This review summarises outcomes on MetS biomarkers in recent clinical trials supplementing ACN, catechins, BG and n-3 LCPUFA, focusing mainly on anti-obesity effects. Overall, it is clear that the level of evidence for the effectiveness varies not only among the different bioactives but also among the different putative health benefits suggested for the same bioactive. Limited evidence may be due to the low number of controlled intervention trials or to inconsistencies in trial design, i.e. duration, dose and/or the method of bioactive supplementation (extracts, supplements, rich or enriched food). At present, the question 'Are bioactives effective in weight management and prevention of metabolic syndrome?' remains inconclusive. Thus, a common effort to harmonise the study design of intervention trials focusing on the most promising bioactive molecules is urgently needed to strengthen the evidence of their potential in the treatment of obesity, MetS and related diseases.
C1 [Bordoni, A.] Univ Bologna, Dept Agrifood Sci & Technol, Cesena, FC, Italy.
   [Boesch, C.; Orfila, C.] Univ Leeds, Sch Food Sci & Nutr, Leeds, W Yorkshire, England.
   [Malpuech-Brugere, C.] Univ Clermont Auvergne, INRA, UNH, Unite Nutr Humaine,CRNH Auvergne, Clermont Ferrand, France.
   [Tomas-Cobos, L.] AINIA, Valencia, Spain.
C3 University of Bologna; University of Leeds; INRAE; Universite Clermont
   Auvergne (UCA)
RP Bordoni, A (corresponding author), Univ Bologna, Dept Agrifood Sci & Technol, Cesena, FC, Italy.
EM alessandra.bordoni@unibo.it
RI Bosch, Christine/AGL-4328-2022; Bordoni, Alessandra/J-3047-2012;
   Malpuech-Brugere, Corinne/D-6848-2017; Tomas-Cobos, Lidia/Q-2707-2018
OI Malpuech-Brugere, Corinne/0000-0001-9286-4647; Tomas-Cobos,
   Lidia/0000-0002-4996-6987; Bosch, Christine/0000-0001-6705-5709; Orfila,
   Caroline/0000-0003-2564-8068
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NR 94
TC 15
Z9 15
U1 2
U2 37
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0029-6651
EI 1475-2719
J9 P NUTR SOC
JI Proc. Nutr. Soc.
PD AUG
PY 2019
VL 78
IS 3
BP 340
EP 350
AR PII S0029665119000545
DI 10.1017/S0029665119000545
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Nutrition & Dietetics
GA IO0OP
UT WOS:000479078500010
PM 30967168
OA Green Submitted, Bronze, Green Accepted
DA 2025-06-11
ER

PT J
AU Iorio, A
   Ylli, D
   Polimanti, R
   Picconi, F
   Maggio, P
   Francomano, D
   Aversa, A
   Manfellotto, D
   Fuciarelli, M
   Frontoni, S
AF Iorio, Andrea
   Ylli, Dorina
   Polimanti, Renato
   Picconi, Fabiana
   Maggio, Paola
   Francomano, Davide
   Aversa, Antonio
   Manfellotto, Dario
   Fuciarelli, Maria
   Frontoni, Simona
TI Effect of the GSTM1 gene deletion on glycemic variability,
   sympatho-vagal balance and arterial stiffness in patients with metabolic
   syndrome, but without diabetes
SO DIABETES RESEARCH AND CLINICAL PRACTICE
LA English
DT Article
DE Genetic polymorphisms; Glucose excursions; AMP-activated protein kinase;
   Autonomic function; Metabolic syndrome
ID CARDIOVASCULAR OUTCOMES; INSULIN RESISTANCE; PULSE PRESSURE; INCREASED
   RISK; GLUCOSE; ACTIVATION; DISEASE; GSTO2-ASTERISK-N142D; POLYMORPHISMS;
   HYPERGLYCEMIA
AB Aims: An increased rate of cerebrovascular complications in patients with metabolic syndrome (MetS) has been reported. Previous studies demonstrated an association between glycemic variability (GV) and cerebrovascular reactivity (CRV) in MetS, thus suggesting a putative role of GVon cerebrovascular events. Although the pathophysiological mechanism linking GV to damage is still to be elucidated, evidence suggests oxidative stress plays a crucial role. Since functional variants in glutathione S-transferases (GST) genes modulate the cellular detoxification processes, the aim of this study was to elucidate the involvement of GSTs in MetS and investigating the correlation with GV, arterial stiffness, and sympathovagal (SV) balance.
   Methods: A hundred metabolic syndrome patients without diabetes underwent GST gene polymorphism analysis and a sub-sample 36 patients were randomly selected to investigate the correlation between GST gene polymorphisms and GV, and sympatho-vagal (SV) balance and arterial stiffness.
   Results: GSTM1 showed a significant association with several GV, arterial stiffness, and SV balance indexes. In particular, the GSTM1 deletion positively correlates with lower values of these indexes when compared to the presence of the gene.
   Conclusions: Therefore, we suggested a global influence of GSTM1 deletion on the GV, arterial stiffness, and SV balance pathways in MetS patients, probably also interacting with AMP-activated protein kinase (AMPK) regulation.
   Conclusions: Our novel findings indicate GSTM1 could be a risk locus in MetS development and shed light novel scenarios on the role of glucose fluctuations in neurological impairments. (C) 2018 Elsevier B.V. All rights reserved.
C1 [Iorio, Andrea; Fuciarelli, Maria] Univ Roma Tor Vergata, Dept Biol, Rome, Italy.
   [Iorio, Andrea] Univ Roma Tor Vergata, Salugene Srls, Rome, Italy.
   [Ylli, Dorina; Picconi, Fabiana; Frontoni, Simona] Univ Roma Tor Vergata, S Giovanni Calibita Fatebenefratelli Hosp, Dept Syst Med, Endocrinol Diabet & Metab, Rome, Italy.
   [Polimanti, Renato] Yale Univ, Sch Med, Dept Psychiat, West Haven, CT USA.
   [Polimanti, Renato] VA CT Healthcare Ctr, West Haven, CT USA.
   [Maggio, Paola] Bolognini Hosp, ASST Bergamo Est, Dept Neurol, Seriate, BG, Italy.
   [Francomano, Davide] Madonna delle Grazie Hosp, Div Internal Med & Endocrinol, Rome, Italy.
   [Aversa, Antonio] Sapienza Univ Rome, Dept Expt Med, Sect Med Pathophysiol Endocrinol & Nutr, Rome, Italy.
   [Manfellotto, Dario] San Giovanni Calibita Fatebenefratelli Hosp, AFaR Fdn, Clin Pathophysiol Ctr, Rome, Italy.
C3 University of Rome Tor Vergata; University of Rome Tor Vergata;
   University of Rome Tor Vergata; Yale University; Sapienza University
   Rome
RP Frontoni, S (corresponding author), S Giovanni Calibita Fatebenefratelli Hosp, Endocrinol Diabet & Metab, Via Ponte Quattro Capi 39, I-00186 Rome, Italy.
EM frontoni@uniroma2.it
RI Picconi, Fabiana/AAB-9012-2019; Maggio, Paola/ABC-7526-2021; Polimanti,
   Renato/B-7577-2013; Aversa, Antonio/O-3151-2019; FRONTONI,
   SIMONA/J-4893-2012; Ylli, Dorina/IYJ-5338-2023
OI Maggio, Paola/0000-0001-8393-7699; Polimanti,
   Renato/0000-0003-0745-6046; Aversa, Antonio/0000-0002-2989-2618; Ylli,
   Dorina/0000-0002-0269-2587; FRONTONI, SIMONA/0000-0001-8241-7552
FU RSA Grant from University of Rome "Tor Vergata"; PRIN from the Italian
   Ministry of Instruction, University and Research (MIUR) [200975T9EW];
   Fatebenefratelli Foundation for Biomedical Research (AFaR division)
FX This study was supported by RSA Grant 2009 from University of Rome "Tor
   Vergata", by PRIN 2009-11 (Project No. 200975T9EW) from the Italian
   Ministry of Instruction, University and Research (MIUR) (M.F.) and by a
   grant from the Fatebenefratelli Foundation for Biomedical Research (AFaR
   division) (D.Y., F.P., D.M., S.F.). The authors declare no conflicts of
   interest.
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NR 49
TC 2
Z9 2
U1 0
U2 4
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0168-8227
EI 1872-8227
J9 DIABETES RES CLIN PR
JI Diabetes Res. Clin. Pract.
PD APR
PY 2018
VL 138
BP 158
EP 168
DI 10.1016/j.diabres.2018.02.006
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA GD4AS
UT WOS:000430445500020
PM 29452132
DA 2025-06-11
ER

PT J
AU Ferrara, LA
   Guida, L
   Ferrara, F
   De Luca, G
   Castaldo, R
   Viola, S
   Russo, R
AF Ferrara, L. Aldo
   Guida, Lucio
   Ferrara, Fabio
   De Luca, Giuliano
   Castaldo, Rosaria
   Viola, Stefania
   Russo, Raffaele
TI Blood pressure at rest, during 24 h monitoring and in response to
   sympathetic stimulation in hypertensive patients with metabolic syndrome
SO INTERNATIONAL JOURNAL OF CARDIOLOGY
LA English
DT Article
DE metabolic syndrome; sympathetic activity; ABPM; isometric exercise; cold
   pressure test
ID INSULIN; DIFFERENCE
AB Objective: As subjects with metabolic syndrome have an increased sympathetic activity regardless of the presence of arterial hypertension, this study aimed at evaluating in hypertensives whether this condition has repercussions on differences in resting, ambulatory and under sympathetic stimulation blood pressure levels.
   Methods: Blood pressure (BP) was measured at rest and in response to isometric exercise and cold pressure test by zero-random sphygmomanometer. Moreover 24 h BP monitoring was performed by using Spacelabs 90207.
   Results: Of the 340 hypertensive patients entering the study, 110 (32%) had metabolic syndrome. They were older (47 vs. 42 years, p < 0.01) than those without MS and, by definition, had increased body mass index, fasting blood glucose and triglycerides and lower HDL-cholesterol. Also BP at rest (148/95 vs. 140/90 mm Hg, p < 0.01), during 24 h (138/89 vs. 129/84 mm Hg, p < 0.001) as well as during daytime and nighttime were significantly increased in this group. No difference, on the other hand, was detected in the response to tests stimulating sympathetic nervous system and in the clinic-daytime BP difference.
   Conclusions: In the present study hypertensive patients with MS have higher BP, both at rest and during ambulatory monitoring in comparison to hypertensives without MS. The BP response to the stimulation of the sympathetic system seems, on the other hand, similar probably because the presence of hypertension in both groups masks during maximal stress the differences evident in less stressing conditions. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
C1 Univ Naples Federico II, Dipartimento Med Clin, I-80131 Naples, Italy.
C3 University of Naples Federico II
RP Ferrara, LA (corresponding author), Univ Naples Federico II, Dipartimento Med Clin, Via Sergio Pansini 5, I-80131 Naples, Italy.
EM Ferrara@Unina.It
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NR 21
TC 11
Z9 11
U1 0
U2 1
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0167-5273
EI 1874-1754
J9 INT J CARDIOL
JI Int. J. Cardiol.
PD MAY 2
PY 2007
VL 117
IS 3
BP 312
EP 316
DI 10.1016/j.ijcard.2006.04.085
PG 5
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 165PQ
UT WOS:000246318100004
PM 16863667
DA 2025-06-11
ER

PT J
AU Saunders, TJ
   McIsaac, T
   Douillette, K
   Gaulton, N
   Hunter, S
   Rhodes, RE
   Prince, SA
   Carson, V
   Chaput, JP
   Chastin, S
   Giangregorio, L
   Janssen, I
   Katzmarzyk, PT
   Kho, ME
   Poitras, VJ
   Powell, KE
   Ross, R
   Ross-White, A
   Tremblay, MS
   Healy, GN
AF Saunders, Travis J.
   McIsaac, Travis
   Douillette, Kevin
   Gaulton, Nick
   Hunter, Stephen
   Rhodes, Ryan E.
   Prince, Stephanie A.
   Carson, Valerie
   Chaput, Jean-Philippe
   Chastin, Sebastien
   Giangregorio, Lora
   Janssen, Ian
   Katzmarzyk, Peter T.
   Kho, Michelle E.
   Poitras, Veronica J.
   Powell, Kenneth E.
   Ross, Robert
   Ross-White, Amanda
   Tremblay, Mark S.
   Healy, Genevieve N.
TI Sedentary behaviour and health in adults: an overview of systematic
   reviews
SO APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
LA English
DT Review
DE sedentary behaviour; guidelines; public health; adults; sitting; screen
   time
ID ALL-CAUSE MORTALITY; PHYSICAL-ACTIVITY; SLEEP DURATION; OLDER-ADULTS;
   TIME; RISK; WORKSTATIONS; METAANALYSIS; PERFORMANCE; GUIDELINES
AB The purpose of this overview of systematic reviews was to determine the relationship between different types and patterns of sedentary behaviour and selected health outcomes in adults and older adults. Five electronic databases were last searched in May, 2019, with a 10-year search limit. Included reviews met the a priori population (community-dwelling adults aged 18 years and older), intervention/exposure/comparator (various types and/or patterns of sedentary behaviour), and outcomes criteria. Eighteen systematic reviews were included in the evidence synthesis. High levels of sedentary behaviour are unfavourably associated with cognitive function, depression, function and disability, physical activity levels, and physical health-related quality of life in adults. Reducing or breaking up sedentary behaviour may benefit body composition and markers of cardiometabolic risk. Total sedentary behaviour and TV viewing were most consistently associated with unfavourable health outcomes, while computer and Internet use may be favourably associated with cognitive function for older adults. The quality of evidence within individual reviews (as assessed by review authors) varied from low to high, while the certainty of evidence was low to very low. These findings have important public health implications, suggesting that adults should avoid high levels of sedentary behaviour and break-up periods of prolonged sitting. (PROSPERO registration nos.: CRD42019123121 and CRD42019127157.)
   Novelty
   High levels of sedentary behaviour are unfavourably associated with important health outcomes in adults.
   Reducing or breaking up sedentary behaviour may benefit body composition and markers of cardiometabolic risk.
   Computer and Internet use may be favourably associated with cognitive function in older adults.
C1 [Saunders, Travis J.; McIsaac, Travis; Douillette, Kevin; Gaulton, Nick] Univ Prince Edward Isl, Dept Appl Human Sci, Charlottetown, PE C1A 4P3, Canada.
   [Hunter, Stephen; Carson, Valerie] Univ Alberta, Fac Kinesiol Sport & Recreat, Edmonton, AB T6G 2H9, Canada.
   [Rhodes, Ryan E.] Univ Victoria, Sch Exercise Sci Phys & Hlth Educ, Victoria, BC V8P 5C2, Canada.
   [Prince, Stephanie A.] Univ Ottawa, Div Cardiac Prevent & Rehabil, Heart Inst, Ottawa, ON K1Y 4W7, Canada.
   [Chaput, Jean-Philippe; Tremblay, Mark S.] Childrens Hosp, Hlth Act Living & Obes Res Grp, Eastern Ontario Res Inst, Ottawa, ON K1H 8L1, Canada.
   [Chastin, Sebastien] Glasgow Caledonian Univ, Sch Hlth & Life Sci, Inst Appl Hlth Res, Glasgow G4 0BA, Lanark, Scotland.
   [Chastin, Sebastien] Univ Ghent, Dept Movement & Sport Sci, Ghent, Belgium.
   [Giangregorio, Lora] Univ Waterloo, Dept Kinesiol, Waterloo, ON N2L 3G1, Canada.
   [Giangregorio, Lora] Univ Waterloo, Schlegel UW Res Inst Aging, Waterloo, ON N2L 3G1, Canada.
   [Janssen, Ian; Ross, Robert] Queens Univ, Sch Kinesiol & Hlth Studies, Kingston, ON K7L 3N6, Canada.
   [Katzmarzyk, Peter T.] Pennington Biomed Res Ctr, Baton Rouge, LA 70808 USA.
   [Kho, Michelle E.] McMaster Univ, Sch Rehabil Sci, Hamilton, ON L8S 1C7, Canada.
   [Ross-White, Amanda] Queens Univ, Queens Univ Lib, Kingston, ON K7L 3N6, Canada.
   [Healy, Genevieve N.] Univ Queensland, Sch Publ Hlth, Herson, Qld 4006, Australia.
C3 University of Prince Edward Island; University of Alberta; University of
   Victoria; University of Ottawa; University of Ottawa Heart Institute;
   University of Ottawa; Children's Hospital of Eastern Ontario; Glasgow
   Caledonian University; Ghent University; University of Waterloo;
   University of Waterloo; Queens University - Canada; Louisiana State
   University System; Louisiana State University; Pennington Biomedical
   Research Center; McMaster University; Queens University - Canada;
   University of Queensland
RP Saunders, TJ (corresponding author), Univ Prince Edward Isl, Dept Appl Human Sci, Charlottetown, PE C1A 4P3, Canada.
EM trsaunders@upei.ca
RI Ross-White, Amanda/N-2408-2019; Tremblay, Mark/ABI-5477-2020; Chaput,
   Jean-Philippe/ABE-6307-2020; Katzmarzyk, Peter/N-1974-2017; Chastin,
   Sebastien/ABF-1455-2020; Prince, Stephanie/J-9361-2019; ,
   Michelle/W-7414-2019; Carson, Valerie/ABG-2853-2021; Janssen,
   Ian/B-7700-2009; Rhodes, Ryan/ABB-4896-2020; Healy,
   Genevieve/A-7408-2008
OI Kho, Michelle/0000-0003-3170-031X; Prince,
   Stephanie/0000-0001-6729-5649; Ross-White, Amanda/0000-0003-4737-0968;
   Rhodes, Ryan/0000-0003-0940-9040; Chastin,
   Sebastien/0000-0003-1421-9348; Healy, Genevieve/0000-0001-7093-7892
FU PHAC; Canadian Society for Exercise Physiology; Queen's University;
   National Health and Medical Research Council of Australia Career
   Development Fellowship; Canadian Institutes of Health Research - PHAC
   Health System Impact Fellowship
FX This study has been made possible through funding from the PHAC, the
   Canadian Society for Exercise Physiology, and Queen's University. I.J.
   and M.E.K. each hold a Canada Research Chair. G.N.H. was supported by a
   National Health and Medical Research Council of Australia Career
   Development Fellowship. S.A.P. was funded by a Canadian Institutes of
   Health Research -PHAC Health System Impact Fellowship. The funder had no
   role in the design, interpretation, and publication of this manuscript.
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NR 68
TC 254
Z9 263
U1 22
U2 164
PU CANADIAN SCIENCE PUBLISHING
PI OTTAWA
PA 65 AURIGA DR, SUITE 203, OTTAWA, ON K2E 7W6, CANADA
SN 1715-5312
EI 1715-5320
J9 APPL PHYSIOL NUTR ME
JI Appl. Physiol. Nutr. Metab.
PD OCT
PY 2020
VL 45
IS 10
SU 2
SI SI
BP S197
EP S217
DI 10.1139/apnm-2020-0272
PG 21
WC Nutrition & Dietetics; Physiology; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nutrition & Dietetics; Physiology; Sport Sciences
GA OH1XT
UT WOS:000582365100008
PM 33054341
OA Green Published, hybrid, Green Accepted
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Le, NA
   Farkas-Epperson, M
   Sweeney, ME
   Wilson, PWF
   Brown, WV
AF Ngoc-Anh Le
   Farkas-Epperson, Monica
   Sweeney, Mary Ellen
   Wilson, Peter W. F.
   Brown, W. Virgil
TI Effect of ABT-335 (fenofibric acid) on meal-induced oxidative stress in
   patients with metabolic syndrome
SO ATHEROSCLEROSIS
LA English
DT Article
DE ABT-335; Fenofibric acid; Metabolic syndrome; Postprandial lipemia;
   Oxidative susceptibility
ID POSTPRANDIAL LIPEMIA; LDL; HDL; ATHEROGENESIS; LIPOPROTEINS;
   CHOLESTEROL; PARAMETERS; INSULIN; PLASMA
AB Objective: Examine the effect of ABT-335 (fenofibric acid) on postprandial lipemia and susceptibility of plasma lipoproteins to Cu++-mediated oxidation in patients with metabolic syndrome.
   Methods and results: This is a randomized double-blind, placebo-controlled study with cross-over and includes a 4-week wash-out period between the two treatment periods. At the end of each 8-week treatment period, subjects were challenged with a standardized mixed meal followed by blood collection over the ensuing 6 h. Plasma lipoproteins were isolated by a combination of ultracentrifugation and FPLC for the continuous monitoring of conjugated dienes formation as an assessment of oxidative susceptibility. Fasting plasma TG was reduced by 20% (p < 0.0002) and there was a modest reduction in hsCRP (6.1%, p < 0.06). There was no change in either HDLc or LDLc in these subjects. Postprandial lipemia was reduced with ABT-335 as demonstrated by a 28.5% reduction (p < 0.0005) in incremental area under the curve for TG during the 6-h period after the meal challenge. Lag times for both fasting LDL (+16%) and postprandial LDL (+28%) were increased with the ABT-335 therapy, suggestive of reduced oxidative susceptibility. Co-incubation with autologous HDL did not reduced LDL oxidative susceptibility in these patients.
   Conclusion: ABT-335 therapy reduced fasting and postprandial triglycerides in patients with metabolic syndrome. Autologous HDL may be dysfunctional in these patients as co-incubation with HDL failed to reduce oxidative susceptibility of LDL. During ABT-335 therapy, LDL was less susceptible to Cu++ mediated oxidative modification, in spite of the lack of changes in LDLc levels. Published by Elsevier Ireland Ltd.
C1 [Ngoc-Anh Le; Farkas-Epperson, Monica; Wilson, Peter W. F.; Brown, W. Virgil] Atlanta VAMC, Biomarker Core Lab, Decatur, GA 30033 USA.
   [Ngoc-Anh Le; Sweeney, Mary Ellen; Wilson, Peter W. F.; Brown, W. Virgil] Emory Univ, Sch Med, Atlanta, GA USA.
   [Sweeney, Mary Ellen] Atlanta VAMC, Lipids Hypertens Clin, Decatur, GA 30033 USA.
C3 US Department of Veterans Affairs; Veterans Health Administration (VHA);
   Atlanta VA Health Care System; Emory University; US Department of
   Veterans Affairs; Veterans Health Administration (VHA); Atlanta VA
   Health Care System
RP Le, NA (corresponding author), Atlanta VAMC, Room 4A183,1670 Clairmont Rd, Decatur, GA 30033 USA.
EM anh.le@va.gov
RI Wilson, Peter/J-2455-2016
OI Le, Ngoc-Anh/0000-0002-2634-4798
FU Abbott; Abbott Park
FX This research is supported by an investigator-initiated research grant
   to N-AL from Abbott, Abbott Park, IL.
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NR 34
TC 1
Z9 1
U1 0
U2 5
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0021-9150
EI 1879-1484
J9 ATHEROSCLEROSIS
JI Atherosclerosis
PD DEC
PY 2013
VL 231
IS 2
BP 268
EP 273
DI 10.1016/j.atherosclerosis.2013.09.022
PG 6
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 259PB
UT WOS:000327537700017
PM 24267238
OA hybrid
DA 2025-06-11
ER

PT J
AU Kyrou, I
   Tsigos, C
AF Kyrou, Ioannis
   Tsigos, Constantine
TI Stress hormones: physiological stress and regulation of metabolism
SO CURRENT OPINION IN PHARMACOLOGY
LA English
DT Review
ID PITUITARY-ADRENAL AXIS; RECOMBINANT HUMAN INTERLEUKIN-6; TYPE-2
   DIABETES-MELLITUS; DEPRESSIVE SYMPTOMS; WEIGHT CHANGE; OBESITY; RISK;
   NEUROENDOCRINE; PATHOGENESIS; INFLAMMATION
AB Stress, defined as a state of threatened homeostasis, mobilizes a complex spectrum of adaptive physiologic and behavioral responses that aim to re-establish the challenged body homeostasis. The hypothalamic-pituitary-ad renal (HPA) axis and the sympathetic nervous system (SNS) constitute the main effector pathways of the stress system, mediating its adaptive functions. In western societies, indices of stress correlate with increasing rates of both obesity and metabolic syndrome which have reached epidemic proportions. Recent data indicate that chronic stress, associated with mild hypercortisolemia and prolonged SNS activation, favors accumulation of visceral fat and contributes to the clinical presentation of visceral obesity, type 2 diabetes, and related cardiometabolic complications. Reciprocally, obesity promotes a systemic low-grade inflammation state, mediated by increased adipokine secretion, which can chronically stimulate the stress system.
C1 [Kyrou, Ioannis] Univ Warwick, Warwick Med Sch, Clin Sci Res Inst, WISDEM,Univ Hosp Coventry & Warwickshire, Coventry CV2 2DX, W Midlands, England.
   [Tsigos, Constantine] YGEIA Hosp Athens, Athens 11528, Greece.
C3 University of Warwick; Hygeia Hospital
RP Kyrou, I (corresponding author), Univ Warwick, Warwick Med Sch, Clin Sci Res Inst, WISDEM,Univ Hosp Coventry & Warwickshire, Coventry CV2 2DX, W Midlands, England.
EM I.Kyrou@warwick.ac.uk; ctsigos@gmail.com
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NR 57
TC 266
Z9 329
U1 1
U2 52
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1471-4892
EI 1471-4973
J9 CURR OPIN PHARMACOL
JI Curr. Opin. Pharmacol.
PD DEC
PY 2009
VL 9
IS 6
BP 787
EP 793
DI 10.1016/j.coph.2009.08.007
PG 7
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 528KX
UT WOS:000272445300017
PM 19758844
DA 2025-06-11
ER

PT J
AU Park, S
   Quinn, L
   Park, CG
   Collins, E
   Hong, OS
   Ferrans, CE
AF Park, Sungwon
   Quinn, Lauretta
   Park, Chang Gi
   Collins, Eileen
   Hong, Oi Saeng
   Ferrans, Carol Estwing
TI Health Behavior Adherence in a Metropolitan-Based Metabolic Syndrome
   Management Program during the COVID-19 Pandemic
SO JOURNAL OF OBESITY & METABOLIC SYNDROME
LA English
DT Article
DE Metabolic syndrome; Health behavior; Disease management; Guideline
   adherence; Republic of Korea
ID LIFE-STYLE FACTORS; SOCIOECONOMIC-STATUS; ASSOCIATION; RISK; WORKING;
   ADULTS
AB Background: The COVID-19 pandemic increased the worldwide prevalence of metabolic syndrome. The purpose of this study was to assess health behavior adherence during the pandemic in adults who had engaged in a metabolic syndrome management program for at least 6 months. This assessment included an evaluation of health behavior changes, factors influencing adherence, and clinical parameters. The city-wide program was operated by the Seoul Metropolitan Government. Methods: Baseline and follow-up data were compared in 116 participants who engaged in the program for at least 6 months prior to the pandemic. Health behaviors and clinical parameters were examined. Generalized estimating equation analysis was used to identify sociodemographic variables influencing health behavior adherence over time. Results: Systolic blood pressure, waist circumference, and blood glucose improved (all P<0.05), and risk factors decreased (P<0.001) from baseline to follow-up (mean +/- standard deviation, 1.13 +/- 0.91 years). All six health behaviors, physical activity and weight control, eating habits, alcohol consumption and smoking, stress management, sleep and rest, and medication compliance and medical examination improved (all P<0.001) from baseline to follow-up (2.37 +/- 1.05 years). Smoking and employment negatively influenced adherence to health behaviors (P<0.05). Participants felt the most beneficial part of the program was receiving sequential medical examination results with follow-up consultations by public health professionals without charge. Conclusion: Our study demonstrated the durability of the impact of the Seoul Program on all six targeted health behaviors as well as clinical parameters. Findings encourage participation in such broad-based programs and development of novel approaches to facilitate success for smokers and employed participants.
C1 [Park, Sungwon] Univ Michigan, Sch Nursing, Dept Hlth Behav & Biol Sci, 400 North Ingalls St, Ann Arbor, MI 48109 USA.
   [Quinn, Lauretta; Park, Chang Gi; Collins, Eileen; Ferrans, Carol Estwing] Univ Illinois, Coll Nursing, Chicago, IL USA.
   [Hong, Oi Saeng] Univ Calif San Francisco, Sch Nursing, Occupat & Environm Hlth Nursing Grad Program, San Francisco, CA USA.
C3 University of Michigan System; University of Michigan; University of
   Illinois System; University of Illinois Chicago; University of Illinois
   Chicago Hospital; University of California System; University of
   California San Francisco
RP Park, S (corresponding author), Univ Michigan, Sch Nursing, Dept Hlth Behav & Biol Sci, 400 North Ingalls St, Ann Arbor, MI 48109 USA.
EM sungwonp@umich.edu
RI Park, Chang/AEN-4164-2022
FU American Association of Occupational Health Nurses Foundation Medique
   New Researcher Grant; Sigma Alpha Lambda Chapter Award, Alpha Lambda
   Chapter of Sigma Theta Tau Honor Society of Nursing; Sherri Mendelson
   Student Research Award, College of Nursing, University of Illinois at
   Chicago (UIC); Award for Graduate Research from UIC Graduate College;
   Global Korean Nursing Foundation USA scholarship award
FX This study was funded by the 2021 American Association of Occupational
   Health Nurses Foundation Medique New Researcher Grant; the 2021 Sigma
   Alpha Lambda Chapter Award, Alpha Lambda Chapter of Sigma Theta Tau
   Honor Society of Nursing; the 2020-2021 Tom and Sherri Mendelson Student
   Research Award, College of Nursing, University of Illinois at Chicago
   (UIC) ; the Award for Graduate Research from UIC Graduate College; and
   the 2020 Global Korean Nursing Foundation USA scholarship award. In
   addition, the authors appreciate all participants in the study.
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NR 34
TC 1
Z9 1
U1 0
U2 1
PU KOREAN SOC STUDY OBESITY
PI SEOUL
PA RENAISSANCE TOWER, 1010  14 MALLIJAE-RO, MAPO-GU, SEOUL, 04195, SOUTH
   KOREA
SN 2508-6235
EI 2508-7576
J9 J OBES METAB SYNDR
JI J. Obes. Metab. Syndr.
PD JUN
PY 2024
VL 33
IS 2
BP 166
EP 176
DI 10.7570/jomes23039
PG 11
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA D3A0L
UT WOS:001294933500008
PM 38253358
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Cheng, HS
   Ton, SH
   Tan, JBL
   Kadir, KA
AF Cheng, Hong Sheng
   Ton, So Ha
   Tan, Joash Ban Lee
   Kadir, Khalid Abdul
TI The Ameliorative Effects of a Tocotrienol-Rich Fraction on the AGE-RAGE
   Axis and Hypertension in High-Fat-Diet-Fed Rats with Metabolic Syndrome
SO NUTRIENTS
LA English
DT Article
DE advanced glycation end product; cholesterol; hepatic steatosis;
   myeloperoxidase; peroxisome proliferator-activated receptor; vitamin E
ID HMG-COA REDUCTASE; NATURAL VITAMIN-E; BLOOD-PRESSURE; PALM OIL;
   INSULIN-SENSITIVITY; DIABETIC-PATIENTS; OXIDATIVE STRESS;
   ACID-METABOLISM; CLINICAL-TRIAL; DOUBLE-BLIND
AB The clinical value of tocotrienols is increasingly appreciated because of the unique therapeutic effects that are not shared by tocopherols. However, their effect on metabolic syndrome is not well-established. This study aimed to investigate the effects of a tocotrienol-rich fraction (TRF) from palm oil in high-fat-diet-treated rats. Male, post-weaning Sprague Dawley rats were provided high-fat (60% kcal) diet for eight weeks followed by a TRF (60 mg/kg) treatment for another four weeks. Physical, metabolic, and histological changes were compared to those on control and high-fat diets respectively. High-fat feeding for eight weeks induced all hallmarks of metabolic syndrome. The TRF reversed systolic and diastolic hypertension, hypercholesterolemia, hepatic steatosis, impaired antioxidant defense, and myeloperoxidase hyperactivity triggered by the high-fat diet. It also conferred an inhibitory effect on protein glycation to reduce glycated hemoglobin A1c and advanced glycation end products (AGE). This was accompanied by the suppression of the receptor for advanced glycation end product (RAGE) expression in the liver. The treatment effects on visceral adiposity, glycemic control, triglyceride level, as well as peroxisome proliferator-activated receptor and expression were negligible. To conclude, treatment with a TRF exhibited protective effects on the cardiovascular and liver health in addition to the amelioration of plasma redox imbalance and AGE-RAGE activation. Further investigation as a therapy for metabolic syndrome is therefore worthwhile.
C1 [Cheng, Hong Sheng; Ton, So Ha; Tan, Joash Ban Lee] Monash Univ Malaysia, Sch Sci, Bandar Sunway 46150, Selangor, Malaysia.
   [Kadir, Khalid Abdul] Monash Univ Malaysia, Sch Med & Hlth Sci, Bandar Sunway 46150, Selangor, Malaysia.
C3 Monash University; Monash University Malaysia; Monash University; Monash
   University Malaysia
RP Cheng, HS (corresponding author), Monash Univ Malaysia, Sch Sci, Bandar Sunway 46150, Selangor, Malaysia.
EM hong.cheng@monash.edu; ton.soha2016@gmail.com; tan.ban.lee@monash.edu;
   khalid.kadir@monash.edu
RI Cheng, Hong Sheng/AAD-6121-2019
OI Cheng, Hong Sheng/0000-0001-9745-7872
FU Ministry of Science, Technology and Innovation, Malaysia (MOSTI)
   [02-02-10-SF0249]; School of Science, Monash University Malaysia
FX The work was funded by the Ministry of Science, Technology and
   Innovation, Malaysia (MOSTI grant: 02-02-10-SF0249) and an internal
   grant from the School of Science, Monash University Malaysia. We would
   like to express our deepest gratitude to Andrew Leong Kum Loong and
   Zulkhaili Zainal Abidin for their assistance in animal handling.
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NR 54
TC 23
Z9 24
U1 1
U2 16
PU MDPI AG
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 2072-6643
J9 NUTRIENTS
JI Nutrients
PD SEP
PY 2017
VL 9
IS 9
AR 984
DI 10.3390/nu9090984
PG 18
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA FI4UM
UT WOS:000411973200067
PM 28880217
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Westerink, J
   Hajer, GR
   Kranendonk, MEG
   Schipper, HS
   Monajemi, H
   Kalkhoven, E
   Visseren, FLJ
AF Westerink, Jan
   Hajer, Gideon R.
   Kranendonk, Mariette E. G.
   Schipper, Henk S.
   Monajemi, Houshang
   Kalkhoven, Eric
   Visseren, Frank L. J.
TI An Oral Mixed Fat Load Is Followed by a Modest Anti-inflammatory
   Adipocytokine Response in Overweight Patients with Metabolic Syndrome
SO LIPIDS
LA English
DT Article
DE Postprandial; Cytokines; Adipocytokines; Metabolic syndrome
ID ACYLATION-STIMULATING PROTEIN; INSULIN-RESISTANCE;
   CARDIOVASCULAR-DISEASE; ENDOTHELIAL FUNCTION; OXIDATIVE STRESS;
   ADIPONECTIN; INFLAMMATION; OBESE; MEAL; GLUCOSE
AB We investigated the postprandial changes in plasma levels of adipocytokines in overweight patients with metabolic syndrome after an oral fat load. After an oral fat load and during a prolonged fast, blood was drawn at 0, 2, 3, 4 and 8 h for measurement of adiponectin, adipsin, cathepsin S, chemerin, hepatic growth factor, interferon-gamma-inducible protein-10, leptin, macrophage chemoattractant protein-1, macrophage migration inhibitory factor, nerve growth factor, retinol binding protein-4, resistin, serum amyloid A1, tissue inhibitor of metalloproteinase-1 and thrombopoietin using a microbead-based Luminex assay. Area under the curves (AUC) were calculated and compared. Plasma adiponectin levels were higher after an oral fat load compared to fasting at t = 2 h (950 +/- A 513 vs. -1,881 +/- A 713 ng/ml) while the plasma levels for adipsin (-9 +/- A 5 vs. 16 +/- A 5 ng/ml), chemerin (-122 +/- A 35 vs. 13 +/- A 21 ng/ml), SAA-1 (-391 +/- A 213 vs. 522 +/- A 173 ng/ml) and TPO (-335 +/- A 144 vs. 622 +/- A 216 ng/ml) were lower after an oral fat load compared to fasting. The baseline corrected AUC for IP-10 was higher after fat load compared to fasting (median -116 pg h/ml; IQR -270 to 10 vs. -21 pg h/ml; IQR -136 to 418 (p = 0.047). In conclusion, in overweight male subjects with the metabolic syndrome, an oral fat load is accompanied with a modest anti-inflammatory response of adipose tissue-derived adipocytokines.
C1 [Westerink, Jan; Hajer, Gideon R.; Kranendonk, Mariette E. G.; Monajemi, Houshang; Visseren, Frank L. J.] Univ Med Ctr Utrecht, Dept Vasc Med, NL-3508 GA Utrecht, Netherlands.
   [Schipper, Henk S.; Kalkhoven, Eric] Univ Med Ctr Utrecht, Dept Metab Dis, Utrecht, Netherlands.
   [Schipper, Henk S.] Univ Med Ctr Utrecht, Wilhelmina Childrens Hosp, Dept Pediat Immunol & Infect Dis, Utrecht, Netherlands.
C3 Utrecht University; Utrecht University Medical Center; Utrecht
   University; Utrecht University Medical Center; Wilhelmina
   Kinderziekenhuis; Utrecht University; Utrecht University Medical Center
RP Westerink, J (corresponding author), Univ Med Ctr Utrecht, Dept Vasc Med, POB 85500, NL-3508 GA Utrecht, Netherlands.
EM j.westerink-3@umcutrecht.nl; F.L.J.Visseren@umcutrecht.nl
RI Westerink, Jan/AAO-7725-2021; Visseren, Frank/I-4855-2013; Schipper,
   Henk/JFJ-5493-2023
OI Visseren, Frank/0000-0003-3951-5223; Schipper, Henk/0000-0003-1997-8060
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NR 41
TC 9
Z9 10
U1 0
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0024-4201
EI 1558-9307
J9 LIPIDS
JI Lipids
PD MAR
PY 2014
VL 49
IS 3
BP 247
EP 254
DI 10.1007/s11745-014-3877-8
PG 8
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA AC6WF
UT WOS:000332665600004
PM 24445379
DA 2025-06-11
ER

PT J
AU Min, SH
   Docherty, SL
   Im, EO
   Hu, X
   Hatch, D
   Yang, Q
AF Min, Se Hee
   Docherty, Sharron L.
   Im, Eun-Ok
   Hu, Xiao
   Hatch, Daniel
   Yang, Qing
TI Identification of high-risk symptom cluster burden group among midlife
   peri-menopausal and post-menopausal women with metabolic syndrome using
   latent class growth analysis
SO WOMENS HEALTH
LA English
DT Article
DE menopause; midlife; symptom; women
ID QUALITY-OF-LIFE; DEPRESSIVE SYMPTOMS; TRAJECTORIES; TRANSITION; HEALTH;
   PREVALENCE; PERIMENOPAUSAL; VASOMOTOR; STRESS
AB Background:Midlife peri-menopausal and post-menopausal women with metabolic syndrome experience multiple co-occurring symptoms or symptom clusters, which often result in significant symptom cluster burden. While they are a high-risk symptom burden group, there are no studies that have focused on identifying symptom cluster trajectories in midlife peri-menopausal and post-menopausal women with metabolic syndrome. Objectives:The objectives were to identify meaningful subgroups of midlife peri-menopausal and post-menopausal women with metabolic syndrome based on their distinct symptom cluster burden trajectories, and to describe the demographic, social, and clinical characteristics of different symptom cluster burden subgroups. Design:This is a secondary data analysis using the longitudinal data from Study of Women's Health Across the Nation. Methods:Multi-trajectory analysis using latent class growth analysis was conducted to join the different developmental trajectories of symptom clusters to identify meaningful subgroups and high-risk subgroup for greater symptom cluster burden over time. Then, descriptive statistics were used to explain the demographic characteristics of each symptom cluster trajectory subgroup, and bivariate analysis to examine the association between each symptom cluster trajectory subgroup and demographic characteristics. Results:A total of four classes were identified: Class 1 (low symptom cluster burden), Classes 2 and 3 (moderate symptom cluster burden), and Class 4 (high symptom cluster burden). Social support was a significant predictor of high symptom cluster burden subgroup and highlights the need to provide routine assessment. Conclusion:An understanding and appreciation for the different symptom cluster trajectory subgroups and their dynamic nature will assist clinicians to offer targeted and routine symptom cluster assessment and management in clinical settings.
C1 [Min, Se Hee] Columbia Univ, Sch Nursing, New York, NY USA.
   [Docherty, Sharron L.; Hatch, Daniel; Yang, Qing] Duke Univ, Sch Nursing, Durham, NC USA.
   [Im, Eun-Ok; Hu, Xiao] Emory Univ, Nell Hodgson Woodruff Sch Nursing, Atlanta, GA USA.
   [Min, Se Hee] Columbia Univ, Sch Nursing, 560 W 168th St, New York, NY 10032 USA.
C3 Columbia University; Duke University; Emory University; Columbia
   University
RP Min, SH (corresponding author), Columbia Univ, Sch Nursing, 560 W 168th St, New York, NY 10032 USA.
EM sm4394@cumc.columbia.edu
RI Hu, Xiaoyu/AAO-2060-2020
OI Yang, Qing/0000-0003-4844-4690; Min, Se Hee/0000-0003-2722-6627
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NR 50
TC 1
Z9 1
U1 1
U2 19
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1745-5057
EI 1745-5065
J9 WOMENS HEALTH
JI Womens Health
PY 2023
VL 19
AR 17455057231160955
DI 10.1177/17455057231160955
PG 12
WC Obstetrics & Gynecology
WE Emerging Sources Citation Index (ESCI)
SC Obstetrics & Gynecology
GA C2VO9
UT WOS:000960557600001
PM 36999312
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Riós, F
   Quintero, A
   Piloni, J
   Cariño, R
   Reyes, A
AF Rios, Fernanda
   Quintero, Aurora
   Piloni, Javier
   Carino, Raquel
   Reyes, Abigail
TI Bioactive compounds of cinnamon and their effect on decreasing metabolic
   syndrome: systematic review. Introduction. Metabolic syndrome (MS)
   increases. Introduction
SO ARCHIVOS LATINOAMERICANOS DE NUTRICION
LA English
DT Article
DE cinnamon; metabolic syndrome; bioactive compounds
ID BLOOD-PRESSURE; IN-VITRO; CHEMICAL-COMPOSITION; OXIDATIVE STRESS;
   EXTRACT; ZEYLANICUM; CINNAMALDEHYDE; METFORMIN; BARK; SUPPLEMENTATION
AB Metabolic syndrome (MS) increases hospital admission and the risk of developing COVID-19. Due to the side effects caused by the drugs used for its treatment, the search for therapeutic alternatives based on bioactive compounds contained in medicinal plants has been chosen. Cinnamon is used as a therapeutic agent due to its proven properties with various mechanisms of action reported in the treatment of various pathologies. Objective. To document the in vitro and in vivo studies, clinical studies and the mechanisms of action reported on the effect of the administration of cinnamon extracts and powder on comorbidities related to MS. Materials and methods. Systematic review of articles in electronic databases, including studies of cinnamon powder, aqueous extracts, ethyl acetate and methanol from cinnamon bark, over a period of 5 years, excluding all those articles related to its antimicrobial, antifungal and antimicrobial effect. cinnamon oil. Results. The evidence of the main bioactive compounds contained in cinnamon validates its potential in the treatment of diseases related to MS, with limited studies that investigate the mechanisms of action corresponding to its biological activities. Conclusions. Research evidence validates its potential in the treatment of these pathologies, due to its main bioactive compounds: cinnamaldehyde, transcinnamaldehyde, cinnamic acid, eugenol, and antioxidants of the proanthocyanidin A type and flavonoids, which participate in various mechanisms of action that activate and they inhibit enzymes, with hypoglycemic (kinase and phosphatase), antiobesogenic (UPC1), anti-inflammatory (NOS and COX), lipid-lowering (HMG-CoA) and antihypertensive (ACE) effects. Arch Latinoam Nutr 2023; 73(1): 74-85.
C1 [Rios, Fernanda; Quintero, Aurora; Piloni, Javier] Univ Autonoma Estado Hidalgo, Inst Ciencias Agr, Ave Univ Km,1 S-N Exhacienda Aquetzalpa, Tulancingo De Bravo 43600, Hidalgo, Mexico.
   [Carino, Raquel; Reyes, Abigail] Univ Autonoma Estado Hidalgo, Fac Ciencias Salud, Biol Reprod Ctr Invest, Dept Med,Lab Quim Med & Farmacol, Pachuca, Mexico.
   Univ Autonoma San Luis Potosi, Ciencias Quim, Ave Manuel Nava 6,Zona Univ, San Luis Potosi, Mexico.
C3 Universidad Autonoma del Estado de Hidalgo; Universidad Autonoma del
   Estado de Hidalgo; Universidad Autonoma de San Luis Potosi
RP Quintero, A (corresponding author), Univ Autonoma Estado Hidalgo, Inst Ciencias Agr, Ave Univ Km,1 S-N Exhacienda Aquetzalpa, Tulancingo De Bravo 43600, Hidalgo, Mexico.
EM aurora_quintero1489@uaeh.edu.mx
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NR 106
TC 0
Z9 0
U1 1
U2 5
PU ARCHIVOS LATINOAMERICANOS NUTRICION
PI CARACAS
PA APARTADO 62778 CHACAO, AVENIDA FRANCISCO MIRANDA, CARACAS 1060,
   VENEZUELA
SN 0004-0622
EI 2309-5806
J9 ARCH LATINOAM NUTR
JI Arch. Latinoam. Nutr.
PD MAR
PY 2023
VL 73
IS 1
BP 74
EP 85
DI 10.37527/2023.73.1.007
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA F5CQ7
UT WOS:000982529800007
OA gold
DA 2025-06-11
ER

PT J
AU Mikolasevic, I
   Racki, S
   Lukenda, V
   Pavletic-Persic, M
   Milic, S
   Orlic, L
AF Mikolasevic, I.
   Racki, S.
   Lukenda, V.
   Pavletic-Persic, M.
   Milic, S.
   Orlic, L.
TI Non-alcoholic fatty liver disease; a part of the metabolic syndrome in
   the renal transplant recipient and possible cause of an allograft
   dysfunction
SO MEDICAL HYPOTHESES
LA English
DT Article
ID CARDIOVASCULAR-DISEASE; KIDNEY-TRANSPLANTATION; DIABETES-MELLITUS; RISK;
   HYPERTENSION; PREVALENCE; MANAGEMENT; DIAGNOSIS
AB Despite all improvements in transplant medicine, renal transplant recipients have a high risk for cardiovascular mortality. A high prevalence of cardiovascular complications in renal transplant recipients (RTR) is explained by cardiovascular risk factors present before transplantation, in addition to the development of new risk factors as well as worsening of preexisting risk factors after transplantation. A majority ot these patients develop metabolic syndrome within a year after the transplantation. The metabolic syndrome (MS) is associated with impaired renal allograft function and increased insulin resistance. Non alcoholic fatty liver disease (NAFLD) represents a liver manifestation of metabolic syndrome and it development is strongly associated with all components of MS in general population. The current importance of NAFLD and its link to the MS has encouraged an interest in its possible role in the development of atherosclerosis in recent years. Considering the fact that all components of MS are more common among renal transplant recipients compared to general population, it would be expected that RTR may have a much higher incidence of NAFLD compared to general population. We propose that the presence of NAFLD in RTR could be a strong predictor in cardiovascular morbidity and mortality. Also, according to the recent investigations about the possible link between NAFLD and chronic kidney disease, we hypothesis that NAFLD may be associated with deteriorating graft function, causing a chronic allograft nephropathy and graft loss. Common factors underlying the pathogenesis of NAFLD and chronic allograft dysfunction may be insulin resistance, oxidative stress, activation of rennin-angiotensin system, and inappropriate secretion of inflammatory cytokines by steatotic and inflamed liver. (C) 2013 Elsevier Ltd. All rights reserved.
C1 [Mikolasevic, I.; Racki, S.; Pavletic-Persic, M.; Orlic, L.] Univ Hosp Ctr Rijeka, Div Internal Med, Dept Nephrol & Dialysis, Rijeka, Croatia.
   [Lukenda, V.] Dr Josip Bencevic Gen Hosp, Dept Internal Med, Slavonski Brod, Croatia.
   [Milic, S.] Univ Hosp Rijeka, Div Internal Med, Dept Gastroenterol, Rijeka, Croatia.
C3 University of Rijeka; University of Rijeka
RP Mikolasevic, I (corresponding author), Univ Hosp Ctr Rijeka, Div Internal Med, Dept Nephrol & Dialysis, Rijeka, Croatia.
EM ivana.mikolasevic@gmail.com
RI Sandra, Milic/S-5858-2018
OI Sandra, Milic/0000-0002-6635-5360
CR [Anonymous], METABOLISM
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NR 27
TC 16
Z9 16
U1 0
U2 9
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0306-9877
EI 1532-2777
J9 MED HYPOTHESES
JI Med. Hypotheses
PD JAN
PY 2014
VL 82
IS 1
BP 36
EP 39
DI 10.1016/j.mehy.2013.10.030
PG 4
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 295WZ
UT WOS:000330148400008
PM 24280560
DA 2025-06-11
ER

PT J
AU Marchesini, G
   Marzocchi, R
   Agostini, F
   Bugianesi, E
AF Marchesini, G
   Marzocchi, R
   Agostini, F
   Bugianesi, E
TI Nonalcoholic fatty liver disease and the metabolic syndrome
SO CURRENT OPINION IN LIPIDOLOGY
LA English
DT Review
DE diabetes; dyslipidemia; hypertension; steatohepatitis; treatment
ID INSULIN-RESISTANCE; HEPATIC STEATOSIS; VITAMIN-E; STEATOHEPATITIS;
   METFORMIN; PENTOXIFYLLINE; ADIPONECTIN; PREVALENCE; PATHOGENESIS;
   FIBROSIS
AB Purpose of review Clinical, epidemiological and biochemical data strongly support the concept that nonalcoholic fatty liver disease is the hepatic manifestation of the metabolic syndrome. Insulin resistance is the common factor connecting obesity, diabetes, hypertension and dyslipidemia with fatty liver and the progression of hepatic disease to steatohepatitis, fibrosis, cirrhosis and hepatocellular carcinoma.
   Recent findings The association of nonalcoholic fatty liver disease with the features of the metabolic syndrome has been confirmed in several epidemiological studies. The diagnostic and clinical significance of raised liver enzymes has been questioned; advanced hepatic disease may also be present in individuals with ultrasonographically detected steatosis and normal aminotransferase levels. The role of adipokines (leptin, adiponectin) and cytokines (tumor necrosis factor-a, interleukin-6, transforming growth factor-P) in disease progression is probably pivotal, mediated by oxidative stress. The importance of iron accumulation in this process has not been confirmed. Treatments aimed at weight loss remain a primary option; among pharmacological interventions, insulin sensitizers (glitazones and metformin) have confirmed beneficial effects on both biochemical and histological data, but new treatments are on the horizon.
   Summary Nonalcoholic fatty liver disease prevalence in Western countries is high and there is a trend towards a further increase, with millions of people at risk of advanced liver disease. The epidemiological evidence, the lifestyle origin of the disease and the cost of pharmacotherapy make prevention a primary goal, and will contribute to making behavior therapy the background treatment. We need specific programs and carefully controlled, randomized studies to tackle simultaneously all the components of the metabolic syndrome.
C1 Alma Mater Studiorum Univ Bologna, Unit Metab Dis, Policlin S Orsola, I-40138 Bologna, Italy.
   Univ Turin, Dept Gastroenterol, I-10124 Turin, Italy.
C3 IRCCS Azienda Ospedaliero-Universitaria di Bologna; University of
   Bologna; University of Turin
RP Alma Mater Studiorum Univ Bologna, Unit Metab Dis, Policlin S Orsola, Via Massarenti 9, I-40138 Bologna, Italy.
EM giulio.marchesini@unibo.it
RI Agostini, Francesco/AFK-7503-2022
OI Marchesini, Giulio/0000-0003-2407-9860; agostini,
   federica/0000-0002-6577-458X
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NR 45
TC 264
Z9 308
U1 0
U2 22
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0957-9672
EI 1473-6535
J9 CURR OPIN LIPIDOL
JI Curr. Opin. Lipidology
PD AUG
PY 2005
VL 16
IS 4
BP 421
EP 427
DI 10.1097/01.mol.0000174153.53683.f2
PG 7
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism; Peripheral
   Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism;
   Cardiovascular System & Cardiology
GA 948FN
UT WOS:000230701500006
PM 15990591
DA 2025-06-11
ER

PT J
AU Scorza, FA
   de Albuquerque, M
   Arida, RM
   Cysneiros, RM
AF Scorza, Fulvio A.
   de Albuquerque, Marly
   Arida, Ricardo M.
   Cysneiros, Roberta Monterazzo
TI Serum levels of magnesium in sudden cardiac deaths among people with
   schizophrenia: hit or miss?
SO ARQUIVOS DE NEURO-PSIQUIATRIA
LA English
DT Article
DE schizophrenia; sudden death; magnesium
ID CARDIOVASCULAR-DISEASE; ATHEROSCLEROSIS RISK; ANTIPSYCHOTIC-DRUGS;
   METABOLIC SYNDROME; CALCIUM
AB Schizophrenia is a devastating mental disorder, affecting cognitive, emotional, and behavioral conditions, ability to work, social functioning, family stability and self-esteem of the patient. People with schizophrenia show a two to three-fold increased risk to die prematurely than those without schizophrenia. Understanding the mechanisms behind sudden cardiac death in individuals with schizophrenia is a key to prevention. Although different mechanisms may be related, there are clear indications that cardiac abnormalities play a potential role. Some antipsychotics may be associated with cardiovascular adverse events, e. g., QT interval prolongation, metabolic dysfunction, blood pressure and heart rate alterations. Magnesium (Mg) abnormalities may lead to various morphological and functional dysfunctions of the heart and low levels of serum Mg are considered to be at high risk for sudden cardiac death. As low serum Mg is associated with detrimental effects on the heart and that antipsychotic-treated schizophrenia patients frequently affect the heart rate, possibly, these factors together must change the normal functioning of the heart and consequently being able to culminate in a catastrophic event.
C1 [Scorza, Fulvio A.; de Albuquerque, Marly] UNIFESP EPM, Disciplina Neurol Expt, BR-04023900 Sao Paulo, Brazil.
   [Arida, Ricardo M.] UNIFESP EPM, Dept Fisiol, BR-04023900 Sao Paulo, Brazil.
   [Cysneiros, Roberta Monterazzo] Univ Presbiteriana Mackenzie, Programa Posgrad Disturbios Desenvolvimento, Sao Paulo, Brazil.
C3 Universidade Federal de Sao Paulo (UNIFESP); Universidade Federal de Sao
   Paulo (UNIFESP); Universidade Presbiteriana Mackenzie
RP Scorza, FA (corresponding author), UNIFESP EPM, Disciplina Neurol Expt, Rua Botucatu 862,Edificio Leal Prado, BR-04023900 Sao Paulo, Brazil.
EM scorza.nexp@epm.br
RI Scorza, Francesco/J-5932-2019; Arida, RIcardo Mario/P-7408-2016; Scorza,
   Fulvio/C-7048-2013; Arida, Ricardo/E-2667-2013
OI Monterazzo Cysneiros, Roberta/0000-0002-3191-9146; Arida, RIcardo
   Mario/0000-0002-7771-6133; Scorza, Fulvio/0000-0002-0694-8674; Arida,
   Ricardo/0000-0002-0908-3274
FU Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP); Conselho
   Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq); Instituto
   Nacional de Neurociencia Translacional; Fundacao de Amparo a Pesquisa do
   Estado de Minas Gerais (FAPEMIG)
FX Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP), Conselho
   Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq), Instituto
   Nacional de Neurociencia Translacional, Fundacao de Amparo a Pesquisa do
   Estado de Minas Gerais (FAPEMIG).
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NR 24
TC 3
Z9 4
U1 0
U2 4
PU ASSOC ARQUIVOS NEURO- PSIQUIATRIA
PI SAO PAULO SP
PA PR AMADEU AMARAL 47/33, 01327-010 SAO PAULO SP, BRAZIL
SN 0004-282X
J9 ARQ NEURO-PSIQUIAT
JI Arq. Neuro-Psiquiatr.
PD OCT
PY 2012
VL 70
IS 10
BP 814
EP 816
DI 10.1590/S0004-282X2012001000011
PG 3
WC Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Psychiatry
GA 019EJ
UT WOS:000309719600011
PM 23060109
OA gold, Green Submitted
DA 2025-06-11
ER

PT J
AU DeVallance, E
   Branyan, KW
   Lemaster, K
   Olfert, IM
   Smith, DM
   Pistilli, EE
   Frisbee, JC
   Chantler, PD
AF DeVallance, Evan
   Branyan, Kayla W.
   Lemaster, Kent
   Olfert, I. Mark
   Smith, David M.
   Pistilli, Emidio E.
   Frisbee, Jefferson C.
   Chantler, Paul D.
TI Aortic dysfunction in metabolic syndrome mediated by perivascular
   adipose tissue TNF- and NOX2-dependent pathway
SO EXPERIMENTAL PHYSIOLOGY
LA English
DT Article
DE metabolic syndrome; perivascular adipose tissue; tumour necrosis factor-
   alpha
ID MICROVASCULAR ENDOTHELIAL-CELLS; ENDOPLASMIC-RETICULUM STRESS;
   NITRIC-OXIDE SYNTHASE; PULSE-WAVE VELOCITY; OBESE ZUCKER RATS; NADPH
   OXIDASE; MATRIX METALLOPROTEINASES; ARTERIAL STIFFNESS; INFLAMMATORY
   RESPONSE; VASCULAR DYSFUNCTION
AB Perivascular adipose tissue (PVAT) is recognized for its vasoactive effects, but it is unclear how metabolic syndrome impacts thoracic aorta (t)PVAT and the subsequent effect on functional and structural aortic stiffness. Thoracic aorta and tPVAT were removed from 16- to 17-week-old lean (LZR, n=16) and obese Zucker rats (OZR, n=16). The OZR presented with aortic endothelial dysfunction, assessed by wire myography, and increased aortic stiffness, assessed by elastic modulus. The OZR tPVAT exudate further exacerbated the endothelial dysfunction, reducing nitric oxide and endothelium-dependent relaxation (P<0.05). Additionally, OZR tPVAT exudate had increased MMP9 activity (P<0.05) and further increased the elastic modulus of the aorta after 72h of co-culture (P<0.05). We found that the observed aortic dysfunction caused by OZR tPVAT was mediated through increased production and release of tumour necrosis factor- (TNF; P<0.01), which was dependent on tPVAT NADPH-oxidase 2 (NOX2) activity. The OZR tPVAT release of reactive oxygen species and subsequent aortic dysfunction were inhibited by TNF neutralization and/or inhibition of NOX2. Additionally, we found that OZR tPVAT had reduced activity of the active sites of the 20S proteasome (P<0.05) and reduced superoxide dismutase activity (P<0.01). In conclusion, metabolic syndrome causes tPVAT dysfunction through an interplay between TNF and NOX2 that leads to tPVAT-mediated aortic stiffness by activation of aortic reactive oxygen species and increased MMP9 activity.
C1 [DeVallance, Evan; Branyan, Kayla W.; Olfert, I. Mark; Pistilli, Emidio E.; Chantler, Paul D.] West Virginia Univ, Div Exercise Physiol, Sch Med, Morgantown, WV USA.
   [Lemaster, Kent; Frisbee, Jefferson C.] Univ Western Ontario, Schulich Sch Med & Dent, Dept Physiol & Pharmacol, London, ON, Canada.
   [Smith, David M.] West Virginia Univ, Dept Biochem, Sch Med, Morgantown, WV USA.
   [Frisbee, Jefferson C.] Univ Western Ontario, Schulich Sch Med & Dent, Dept Med Biophys, London, ON, Canada.
C3 West Virginia University; Western University (University of Western
   Ontario); West Virginia University; Western University (University of
   Western Ontario)
RP Chantler, PD (corresponding author), One Med Ctr Dr, Morgantown, WV 26505 USA.
EM pchantler@hsc.wvu.edu
RI Smith, David/AAL-7662-2020
OI Chantler, Paul/0000-0001-6960-9728; Branyan, Kayla/0000-0003-1038-8080;
   Smith, David/0000-0002-1502-676X; Frisbee, Jefferson/0000-0003-2751-0599
FU American Heart Association [IRG14330015]; AHA [14PRE20380386,
   16PRE30820000]; National Institute of General Medical Sciences of the
   National Institutes of Health [U54GM104942, 5P20GM109098]; American
   Heart Association (AHA) [16PRE30820000, 14PRE20380386] Funding Source:
   American Heart Association (AHA)
FX This study was supported by the American Heart Association grants
   IRG14330015, pre-doctoral fellowship AHA (14PRE20380386, 16PRE30820000);
   and National Institute of General Medical Sciences of the National
   Institutes of Health (U54GM104942 and 5P20GM109098).
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U1 0
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PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0958-0670
EI 1469-445X
J9 EXP PHYSIOL
JI Exp. Physiol.
PD APR 1
PY 2018
VL 103
IS 4
BP 590
EP 603
DI 10.1113/EP086818
PG 14
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA GB1YV
UT WOS:000428848500019
PM 29349831
OA Bronze, Green Accepted
DA 2025-06-11
ER

PT J
AU Medeiros, RF
   Gaique, TG
   Bento-Bernardes, T
   Kindlovits, R
   Gomes, TMB
   Motta, NAV
   Brito, FC
   Fernandes-Santos, C
   Oliveira, KJ
   Nóbrega, ACL
AF Medeiros, Renata F.
   Gaique, Thaiane G.
   Bento-Bernardes, Thais
   Kindlovits, Raquel
   Gomes, Tamiris M. B.
   Motta, Nadia Alice V.
   Brito, Fernanda Carla
   Fernandes-Santos, Caroline
   Oliveira, Karen J.
   Nobrega, Antonio Claudio L.
TI Arginine and aerobic training prevent endothelial and metabolic
   alterations in rats at high risk for the development of the metabolic
   syndrome
SO BRITISH JOURNAL OF NUTRITION
LA English
DT Article
DE Metabolic syndrome; Fructose; Aerobic training; Arginine supplementation
ID TYPE-2 DIABETES-MELLITUS; HEART-FAILURE RATS; FRUCTOSE FED RATS;
   INSULIN-RESISTANCE; PHYSICAL-ACTIVITY; NITRIC-OXIDE;
   CARDIOVASCULAR-DISEASE; DIETARY FRUCTOSE; OXIDATIVE STRESS;
   HYPERCHOLESTEROLEMIC RABBIT
AB Endothelial function is a key mechanism in the development of CVD. Arginine and exercise are important non-pharmacological strategies for mitigating the impact of metabolic changes in the metabolic syndrome, but the effect of their combined administration is unknown. Thus, the aim of this study was to investigate the isolated and combined effects of aerobic training and arginine supplementation on metabolic variables and vascular reactivity in rats at high risk for developing the metabolic syndrome. Wistar rats were divided into two groups: control and fructose (F-water with 10% fructose). After 2 weeks, the F group was divided into four groups: F, fructose + arginine (FA, 880 mg/kg per d of L-arginine), fructose + training (FT) and fructose + arginine + training (FTA); treatments lasted for 8 weeks, and no difference was observed in body mass gain. Arginine did not improve the body protein content, and both the FA and FT groups show a reversal of the increase in adipose tissue. Insulin increase was prevented by training and arginine, without additive effect, and the increase in serum TAG was prevented only by training. The F group showed impaired endothelium-dependent vasodilation and hyperreactivity to phenylephrine, but arginine and training were capable of preventing these effects, even separately. Higher nitric oxide level was observed in the FA and FT groups, and no potentiating effect was detected. Thus, only training was able to prevent the increase in TAG and improve the protein mass, and training and arginine exert similar effects on fat content, insulin and endothelial function, but these effects are not additive.
C1 [Medeiros, Renata F.; Gaique, Thaiane G.; Bento-Bernardes, Thais; Kindlovits, Raquel; Gomes, Tamiris M. B.; Motta, Nadia Alice V.; Brito, Fernanda Carla; Oliveira, Karen J.; Nobrega, Antonio Claudio L.] Fluminense Fed Univ, Dept Physiol & Pharmacol, BR-24210130 Niteroi, RJ, Brazil.
   [Fernandes-Santos, Caroline] Fluminense Fed Univ, Dept Basic Sci, BR-28625650 Nova Friburgo, RJ, Brazil.
C3 Universidade Federal Fluminense; Universidade Federal Fluminense
RP Medeiros, RF (corresponding author), Fluminense Fed Univ, Dept Physiol & Pharmacol, BR-24210130 Niteroi, RJ, Brazil.
EM frauches.renata@gmail.com
RI brito, fernanda/AAL-8474-2021; Oliveira, Karen/AAV-6843-2020;
   Bento-Bernardes, Thais/AAZ-4284-2021; Medeiros, Renata/AAP-3429-2021;
   Fernandes-Santos, Caroline/M-1794-2019
OI Kindlovits, Raquel/0000-0003-2720-0603; Oliveira,
   Karen/0000-0003-2320-8683; Fernandes-Santos,
   Caroline/0000-0002-2420-3836
FU CAPES (Coordination for the Improvement of Higher Education Personnel)
   [473816/2014-8]; FAPERJ (State of Rio de Janeiro Agency for Research
   Support) [110.310/2014]; CNPq (National Council of Scientific and
   Technological Development) [487.584/2013-9]
FX This work was supported by CAPES (Coordination for the Improvement of
   Higher Education Personnel; grant no. 473816/2014-8), FAPERJ (State of
   Rio de Janeiro Agency for Research Support; grant no. 110.310/2014) and
   CNPq (National Council of Scientific and Technological Development;
   grant no. 487.584/2013-9).
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NR 88
TC 12
Z9 13
U1 0
U2 6
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1145
EI 1475-2662
J9 BRIT J NUTR
JI Br. J. Nutr.
PD JUL
PY 2017
VL 118
IS 1
BP 1
EP 10
DI 10.1017/S0007114517001702
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA FG0VT
UT WOS:000409501300001
PM 28799895
OA Bronze
DA 2025-06-11
ER

PT J
AU Achike, FI
   To, NHP
   Wang, HD
   Kwan, CY
AF Achike, Francis I.
   To, Nim-Hin Peter
   Wang, Huide
   Kwan, Chiu-Yin
TI Obesity, metabolic syndrome, adipocytes and vascular function: A
   holistic viewpoint
SO CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
LA English
DT Review
DE diabetes mellitus; metabolic syndrome; obesity; perivascular adipose
   tissue; vascular reactivity
ID PERIVASCULAR ADIPOSE-TISSUE; HYPOTHALAMIC NEUROPEPTIDE-Y; GROWTH-HORMONE
   SECRETAGOGUE; ANGIOTENSIN-II; INFLAMMATORY CYTOKINES;
   INSULIN-RESISTANCE; EPIDEMIOLOGIC DATA; ADIPONECTIN LEVELS; OXIDATIVE
   STRESS; WEIGHT-LOSS
AB P>1. Obesity is a metabolic disease of pandemic proportions largely arising from positive energy balance, a consequence of sedentary lifestyle, conditioned by environmental and genetic factors. Several central and peripheral neurohumoral factors (the major ones being the anorectic adipokines leptin and adiponecin and the orexigenic gut hormone ghrelin) acting on the anorectic (pro-opiomelanocortin and cocaine- and amphetamine-regulated transcript) and orexigenic (neuropeptide Y and agouti gene-related protein) neurons regulate energy balance. These neurons, mainly in the arcuate nucleus of the hypothalamus, project to parts of the brain modulating functions such as wakefulness, autonomic function and learning. A tilt in the anorectic-orexigenic balance, perhaps determined genetically, leads to obesity.
   2. Excess fat deposition requires space, created by adipocyte (hypertrophy and hyperplasia) and extracellular matrix (ECM) remodelling. This process is regulated by several factors, including several adipocyte-derived Matrix metalloproteinases and the adipokine cathepsin, which degrades fibronectin, a key ECM protein. Excess fat, also deposited in visceral organs, generates chronic low-grade inflammation that eventually triggers insulin resistance and the associated comorbidities of metabolic syndrome (hypertension, atherosclerosis, dyslipidaemia and diabetes mellitus).
   3. The perivascular adipose tissue (PVAT) has conventionally been considered non-physiological structural tissue, but has recently been shown to serve a paracrine function, including the release of adipose-derived relaxant and contractile factors, akin to the role of the vascular endothelium. Thus, PVAT regulates vascular function in vivo and in vitro, contributing to the cardiovascular pathophysiology of the metabolic syndrome. Defining the mechanism of PVAT regulation of vascular reactivity requires more and better controlled investigations than currently seen in the literature.
C1 [To, Nim-Hin Peter; Kwan, Chiu-Yin] China Med Univ, Vasc Biol Res Grp, Taichung, Taiwan.
   [Achike, Francis I.] Int Med Univ, Kuala Lumpur 57000, Malaysia.
   [Wang, Huide] Brock Univ, St Catharines, ON L2S 3A1, Canada.
C3 China Medical University Taiwan; International Medical University
   Malaysia; Brock University
RP Kwan, CY (corresponding author), China Med Univ & Hosp, Vasc Biol Res Grp, 91 Hsue Shih Rd, Taichung 40402, Taiwan.
EM kwancy@mail.cmu.edu.tw
RI Achike, Francis/AAH-5695-2021
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NR 112
TC 93
Z9 107
U1 0
U2 25
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0305-1870
EI 1440-1681
J9 CLIN EXP PHARMACOL P
JI Clin. Exp. Pharmacol. Physiol.
PD JAN
PY 2011
VL 38
IS 1
BP 1
EP 10
DI 10.1111/j.1440-1681.2010.05460.x
PG 10
WC Pharmacology & Pharmacy; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Physiology
GA 700RX
UT WOS:000285763100001
PM 21083697
DA 2025-06-11
ER

PT J
AU Adeyemi, DH
   Odetayo, AF
   Hamed, MA
   Akhigbe, RE
AF Adeyemi, D. H.
   Odetayo, A. F.
   Hamed, M. A.
   Akhigbe, R. E.
TI Impact of COVID 19 on erectile function
SO AGING MALE
LA English
DT Review
DE Coronavirus; SARS-CoV-2; COVID-19; endothelial dysfunction; erectile
   dysfunction; testosterone
ID RESPIRATORY SYNDROME CORONAVIRUS; TUMOR-NECROSIS-FACTOR;
   CARDIOVASCULAR-DISEASE; SEXUAL DYSFUNCTION; TESTOSTERONE LEVELS;
   ANGIOTENSIN-II; METABOLIC SYNDROME; PENILE ERECTION; UNITED-STATES;
   MENTAL-HEALTH
AB Purpose: COVID-19, a novel infection, presented with several complications, including socioeconomical and reproductive health challenges such as erectile dysfunction (ED). The present review summarizes the available shreds of evidence on the impact of COVID-19 on ED. Materials and methods: All published peer-reviewed articles from the onset of the COVID-19 outbreak to date, relating to ED, were reviewed. Results: Available pieces of evidence that ED is a consequence of COVID-19 are convincing. COVID-19 and ED share common risk factors such as disruption of vascular integrity, cardiovascular disease (CVD), cytokine storm, diabetes, obesity, and chronic kidney disease (CKD). COVID-19 also induces impaired pulmonary haemodynamics, increased ang II, testicular damage and low serum testosterone, and reduced arginine-dependent NO bioavailability that promotes reactive oxygen species (ROS) generation and endothelial dysfunction, resulting in ED. In addition, COVID-19 triggers psychological/mental stress and suppresses testosterone-dependent dopamine concentration, which contributes to incident ED. Conclusions: In conclusion, COVID-19 exerts a detrimental effect on male reproductive function, including erectile function. This involves a cascade of events from multiple pathways. As the pandemic dwindles, identifying the long-term effects of COVID-19-induced ED, and proffering adequate and effective measures in militating against COVID-19-induced ED remains pertinent.
C1 [Adeyemi, D. H.] Osun State Univ, Coll Hlth Sci, Dept Physiol, Fac Basic Med Sci, Osogbo, Nigeria.
   [Odetayo, A. F.] Univ Ilorin, Dept Physiol, Ilorin, Nigeria.
   [Odetayo, A. F.; Hamed, M. A.; Akhigbe, R. E.] Oasis Grace Hosp, Reprod Biol & Toxicol Res Lab, Osogbo, Osun State, Nigeria.
   [Hamed, M. A.] Brainwill Labs, Osogbo, Nigeria.
   [Hamed, M. A.] Afe Babalola Univ, Coll Med & Hlth Sci, Dept Med Lab Sci, Ado Ekiti, Nigeria.
   [Akhigbe, R. E.] Ladoke Akintola Univ Technol, Dept Physiol, Ogbomosho, Oyo State, Nigeria.
C3 University of Ilorin
RP Akhigbe, RE (corresponding author), Oasis Grace Hosp, Reprod Biol & Toxicol Res Lab, Osogbo, Osun State, Nigeria.; Akhigbe, RE (corresponding author), Ladoke Akintola Univ Technol, Dept Physiol, Ogbomosho, Oyo State, Nigeria.
EM akhigberoland@gmail.com
RI Odetayo, Adeyemi/JNR-7505-2023; Hamed, Moses/CAH-6613-2022
OI Akhigbe, Roland/0000-0002-3874-5927; Odetayo,
   Adeyemi/0000-0002-9089-7610; Hamed, Moses/0000-0003-3378-6794
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NR 208
TC 29
Z9 29
U1 1
U2 40
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1368-5538
EI 1473-0790
J9 AGING MALE
JI Aging Male
PD DEC 31
PY 2022
VL 25
IS 1
BP 202
EP 216
DI 10.1080/13685538.2022.2104833
PG 15
WC Endocrinology & Metabolism; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Urology & Nephrology
GA 3N2HT
UT WOS:000835973700001
PM 35924485
OA gold
DA 2025-06-11
ER

PT J
AU Atad, OI
   Toker, S
AF Atad, Ofer I. I.
   Toker, Sharon
TI Subjective Workload and the Metabolic Syndrome: An Exploration of the
   Mediating Role of Burnout and the Moderating Effect of Physical Activity
SO INTERNATIONAL JOURNAL OF STRESS MANAGEMENT
LA English
DT Article
DE metabolic syndrome; workload; physical activity; burnout; stress
ID EFFORT-REWARD IMBALANCE; CORONARY-HEART-DISEASE; RISK-FACTORS;
   CARDIOVASCULAR-DISEASE; JOB DEMANDS; LIFE-STYLE; FOLLOW-UP; STRESS;
   ADULTS; METAANALYSIS
AB In this study, building on Hobfoll's (1989) conservation of resources theory, we aimed to reveal the effect of subjective workload at baseline on the likelihood of developing new-onset of metabolic syndrome (MetS), a cluster of cardiovascular risk factors during follow-up. We also aimed to find out whether an increase in job burnout mediates this association, and whether the extent of engagement in leisure-time physical activity (PA) attenuates the effect of workload on MetS. Using a three-wave longitudinal study design, we followed a sample of 1,966 Israeli employees free of MetS at baseline for 3.5 years on average. We controlled for multiple confounders, including objective workload (i.e., work hours). Subjective workload at baseline was associated with the risk of new-onset of MetS, yet this association was moderated by PA. Specifically, among participants with low PA (37 weekly minutes), a one-point increase in our five-point measure of subjective workload was associated with a 41% increase in risk of new-onset MetS, whereas among those with high PA (258 weekly minutes) it was associated with a 38% reduction in risk. Among participants who engaged in 148 weekly minutes of PA (as recommended by the U.S. Department of Health and Human Services), an increase in workload did not result in an increased risk of developing MetS. We did not find, however, any indication for a mediating effect of job burnout. Our findings suggest that engaging in PA while being overloaded not only protects employees from adverse outcomes but actually reverses the cardiovascular risk.
C1 [Atad, Ofer I. I.] Peres Acad Ctr, Sch Business, Rehovot, Israel.
   [Toker, Sharon] Tel Aviv Univ, Coller Sch Management, Tel Aviv, Israel.
   [Atad, Ofer I. I.] Peres Acad Ctr, Sch Business, Shimon Peres St 10, IL-7610202 Rehovot, Israel.
C3 Tel Aviv University
RP Atad, OI (corresponding author), Peres Acad Ctr, Sch Business, Shimon Peres St 10, IL-7610202 Rehovot, Israel.
EM ofer.atad@gmail.com
RI ; Toker, Sharon/P-5428-2015
OI Atad, Ofer/0000-0002-5678-4022; Toker, Sharon/0000-0001-7621-6607
FU Arie Shirom Foundation [01-2015]; Henry Crown Institute, Tel-Aviv
   University
FX This research was supported by grants from the Arie Shirom Foundation
   (Grant 01-2015 to Ofer I. Atad) and the Henry Crown Institute, Tel-Aviv
   University. The authors would like to thank Itzhak Shapira, Shlomo
   Berliner, and Samuel Melamed for their theoretical contribution and
   financial support throughout the project.
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NR 92
TC 4
Z9 4
U1 1
U2 20
PU EDUCATIONAL PUBLISHING FOUNDATION-AMERICAN PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST, NE, WASHINGTON, DC 20002-4242 USA
SN 1072-5245
EI 1573-3424
J9 INT J STRESS MANAGE
JI Int. J. Stress Manage.
PD FEB
PY 2023
VL 30
IS 1
BP 95
EP 107
DI 10.1037/str0000270
EA JAN 2023
PG 13
WC Psychology, Applied
WE Social Science Citation Index (SSCI)
SC Psychology
GA I0YY9
UT WOS:000906005900001
DA 2025-06-11
ER

PT J
AU Redina, OE
   Smolenskaya, SE
   Maslova, LN
   Markel, AL
AF Redina, Olga E.
   Smolenskaya, Svetlana E.
   Maslova, Larissa N.
   Markel, Arcady L.
TI The Genetic Control of Blood Pressure and Body Composition in Rats with
   Stress-Sensitive Hypertension
SO CLINICAL AND EXPERIMENTAL HYPERTENSION
LA English
DT Article
DE blood pressure; body composition; QTL; ISIAH rats; stress-induced
   arterial hypertension
ID QUANTITATIVE TRAIT LOCI; INDUCED ARTERIAL-HYPERTENSION; OXIDATIVE
   STRESS; METABOLIC SYNDROME; EMOTIONAL-STRESS; CONGENIC STRAINS;
   HEART-FAILURE; RENAL INJURY; ISIAH RATS; SALT
AB The genetic basis of the stress-sensitive arterial hypertension was investigated using the quantitative trait loci (QTL) approach. Two groups of F-2 (inherited stress-induced arterial hypertension [ISIAH] x Wistar albino Glaxo [WAG]) hybrid males of different age (3-4 months old and 6 months old) were tested for blood pressure at rest and stressed conditions and for body composition traits. Several novel loci for the traits were determined. Some loci for blood pressure and organ weight were mapped to the same genetic region in rats of different age. The dynamic change of QTL effects in two rat groups of different age might reflect the process of stress-sensitive hypertension development.
C1 [Redina, Olga E.; Smolenskaya, Svetlana E.; Maslova, Larissa N.; Markel, Arcady L.] Russian Acad Sci, Inst Cytol & Genet, Siberian Branch, Novosibirsk 630090, Russia.
   [Markel, Arcady L.] Novosibirsk State Univ, Novosibirsk 630090, Russia.
C3 Russian Academy of Sciences; Siberian Branch of the Russian Academy of
   Sciences; Institute of Cytology & Genetics ICG SB RAS; Novosibirsk State
   University
RP Redina, OE (corresponding author), Russian Acad Sci, Inst Cytol & Genet, Siberian Branch, 10 Lavrentieva Ave, Novosibirsk 630090, Russia.
EM oredina@ngs.ru
RI Redina, Olga/T-1650-2017
OI Redina, Olga/0000-0003-0942-8460
FU Russian Foundation for Basic Research; Presidium Programs of Russian
   Academy of Sciences [6.15, 27.26]
FX This work was supported by the Russian Foundation for Basic Research and
   partly by Presidium Programs of Russian Academy of Sciences: "Molecular
   and Cellular Biology" (grant 6.15) and "Biodiversity" (grant 27.26).
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NR 60
TC 15
Z9 16
U1 0
U2 8
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1064-1963
EI 1525-6006
J9 CLIN EXP HYPERTENS
JI Clin. Exp. Hypertens.
PY 2013
VL 35
IS 7
BP 484
EP 495
DI 10.3109/10641963.2012.758274
PG 12
WC Pharmacology & Pharmacy; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Cardiovascular System & Cardiology
GA 231JX
UT WOS:000325413800002
PM 23302051
DA 2025-06-11
ER

PT J
AU Han, J
   Wang, RY
   Bai, LJ
   Liu, Y
   Liao, M
   Zhang, LT
   Liu, LH
   Qi, BL
AF Han, Jing
   Wang, Ruiyun
   Bai, Lijuan
   Liu, Yun
   Liao, Man
   Zhang, Liting
   Liu, Lihua
   Qi, Benling
TI Impact of serum carotenoids on cardiovascular mortality risk in
   middle-aged and elderly adults with metabolic syndrome
SO FRONTIERS IN NUTRITION
LA English
DT Article
DE cardiovascular mortality; carotenoids; antioxidant; metabolic syndrome;
   NHANES
ID PLASMA LYCOPENE; OXIDATIVE STRESS; BETA-CAROTENE; OLDER-ADULTS; DISEASE;
   ASSOCIATION; PREVALENCE; ATHEROSCLEROSIS; ANTIOXIDANT; CHOLESTEROL
AB Background Metabolic syndrome (MetS), characterized by abdominal adiposity, hypertension, hyperglycemia, and dyslipidemia, is associated with dysregulated immune function, elevated oxidative stress, and chronic low-grade inflammation. Aging exacerbates insulin resistance and the prevalence of MetS. Dietary antioxidants, such as carotenoids, may play a role in preventing cardiovascular disease (CVD) mortality, but evidence remains mixed, particularly among middle-aged and elderly individuals with MetS.Methods We analyzed data from 6,601 participants aged 40 years and above with MetS from the National Health and Nutrition Examination Survey (NHANES) III (1988-1994) and NHANES 2001-2006 cycles. Serum concentrations of alpha-carotene, beta-carotene, lycopene, beta-cryptoxanthin, and combined lutein/zeaxanthin were quantified. Participants were followed for a median of 16.8 years. Cox proportional-hazards models were used to assess the association between serum carotenoid concentrations and CVD mortality risk, with adjustment for potential confounders.Results During the follow-up period, 1,237 CVD deaths were identified. Analysis revealed an inverse dose-response relationship between serum lycopene levels and cardiovascular mortality risk. Compared to the lowest quartile, the multivariable-adjusted hazard ratios (95% confidence intervals) for ascending quartiles of serum lycopene were 0.84 (0.71, 1.00), 0.87 (0.74, 1.03), and 0.77 (0.61, 0.97), with a significant trend (p = 0.039). No significant associations were observed for other carotenoids.Conclusion In this prospective cohort study of 40-year-old and older individuals with MetS, we observed an inverse association between serum lycopene levels and CVD mortality risk.
C1 [Han, Jing; Wang, Ruiyun; Bai, Lijuan; Liu, Yun; Liao, Man; Zhang, Liting; Liu, Lihua; Qi, Benling] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Geriatr, Wuhan, Hubei, Peoples R China.
C3 Huazhong University of Science & Technology
RP Liu, LH; Qi, BL (corresponding author), Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Geriatr, Wuhan, Hubei, Peoples R China.
EM huahuahbhb@163.com; qibenlingok_2015@163.com
FU National Natural Science Foundation of China10.13039/501100001809
FX The authors thank the staff and the participants of the NHANES study for
   their valuable contributions. During the writing of this work, the
   authors used OpenAI's Chatgpt 3.5 in order to check grammar, spelling
   and optimize sentences to enhance the readability of the article. After
   using this tool/service, the authors reviewed and edited the content as
   necessary and take full responsibility for the content of the
   publication.
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NR 51
TC 1
Z9 1
U1 0
U2 0
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD NOV 13
PY 2024
VL 11
AR 1465972
DI 10.3389/fnut.2024.1465972
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA N3D5P
UT WOS:001363186000001
PM 39606575
OA gold
DA 2025-06-11
ER

PT J
AU Robichaud, V
   Shankar, S
   Holkem, AT
   Salmieri, S
   Aguilar-Uscanga, BR
   Millette, M
   Lacroix, M
AF Robichaud, Valerie
   Shankar, Shiv
   Holkem, Augusto Tasch
   Salmieri, Stephane
   Aguilar-Uscanga, Blanca R.
   Millette, Mathieu
   Lacroix, Monique
TI Anticancer properties and prevention of metabolic syndrome by
   probiotic-enriched powdered human milk
SO FOOD BIOSCIENCE
LA English
DT Article
DE Human milk; Probiotic formulation; In vitro studies; Metabolic syndrome
ID OXIDATIVE STRESS; CANCER; APOPTOSIS; ASSOCIATION; MECHANISMS;
   COMPONENTS; CELLS
AB This work aimed to develop a novel formulation based on human milk (HM) enriched with a probiotic formulation comprised of Lactobacillus acidophilus CL1285, Lactobacillus casei LBC80R and Lactobacillus rhamnosus CLR2 and to evaluate in vitro and in vivo anticancer properties and its impact on the prevention of risk factors of metabolic syndrome (MetS). In vitro studies were conducted on Hepa-1c1c7, HT-29, and CHO-K1 cell lines to assess the antiproliferative and anticancer properties of HM and probiotics. The in vivo study was conducted with 28 male Wistar rats fed a high-fat diet (HFD). Rats were daily force-fed with HM and HM + probiotics or water for 8 weeks. Inflammation and oxidative stress were monitored through blood cytokines and kidney investigation. Body weight and blood glucose were recorded throughout the study. The results showed that HM had antiproliferative properties and caused apoptosis of intestinal tumoral cells. Quinone reductase (QR) was induced up to 1.8x in Hepa-1c1c7 cell line demonstrating chemotherapeutic potential. HM enriched with probiotics reduced weight gain by 10% while renal oxidative damages were reduced by up to 97%. Blood insulin and Plasminogen Activator Inhibitor-1 (PAI-1) levels were also significantly reduced. The study showed that HM had antiproliferative and chemopreventive properties on cancer cell lines. The in vivo experiment suggests that the development of a formulation based on HM powder enriched with probiotics could be used to modulate the rate of inflammation and oxidative damage to tissues, thus reducing the risk of obesity-related diseases.
C1 [Robichaud, Valerie; Shankar, Shiv; Holkem, Augusto Tasch; Salmieri, Stephane; Aguilar-Uscanga, Blanca R.; Millette, Mathieu; Lacroix, Monique] Inst Nutr & Funct Foods INAF, MAPAQ Res Chair Food Safety & Qual, INRS Armand Frappier Hlth Biotechnol Res Ctr, Canadian Irradiat Ctr CIC,Res Labs Sci Appl Food R, 531 Prairies Blvd, Laval, PQ H7V 1B7, Canada.
   [Holkem, Augusto Tasch] Univ Sao Paulo, Fac Zootecnia & Engn Alimentos, Ave Duque Caxias Norte 225, BR-13635900 Pirassununga, SP, Brazil.
   [Aguilar-Uscanga, Blanca R.] Univ Guadalajara, Ctr Univ Ciencias Exactas & Ingn, Blvd Marcelino Garcia Barragan 1421, Guadalajara 44420, Jalisco, Mexico.
   [Millette, Mathieu] Kerry Co, Preclin Res Div, Bio K, 495 Armand Frappier Blvd, Laval, PQ H7V 4B3, Canada.
C3 Laval University; Universidade de Sao Paulo; Universidad de Guadalajara
RP Lacroix, M (corresponding author), Inst Nutr & Funct Foods INAF, MAPAQ Res Chair Food Safety & Qual, INRS Armand Frappier Hlth Biotechnol Res Ctr, Canadian Irradiat Ctr CIC,Res Labs Sci Appl Food R, 531 Prairies Blvd, Laval, PQ H7V 1B7, Canada.
EM monique.lacroix@inrs.ca
RI Holkem, Augusto/AAL-6257-2021
OI Millette, Mathieu/0000-0002-9134-3249
FU Ministere des Relations internationales et de la Francophonie (MRIF) of
   Quebec [30400201]; Ministere de l'Economie, de la Science et de
   l'Innovation (MESI) of Quebec [PSR-SIIRI-984]; Research
   Foundation-Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
   [15/19375-0, 18/05315-3]; NSERC
FX Hema-Quebec and the Human Milk Bank of Hospital Civil de Guadalajara
   (Fray Antonio Alcade neonatal intensive care unit, Jalisco, Mexico) are
   sincerely acknowledged for providing human milk. This research was
   supported by the Ministere des Relations internationales et de la
   Francophonie (MRIF) of Quebec (XVIth Quebec-Mexico Working group
   2017-2019 #30400201) , and the Ministere de l'Economie, de la Science et
   de l'Innovation (MESI) of Quebec (PSR-SIIRI-984) . The authors also
   thank the Sao Paulo Research Foundation-Fundacao de Amparo a Pesquisa do
   Estado de Sao Paulo (FAPESP) for the scholarship in Brazil (Process
   #15/19375-0) and scholarship abroad (Process #18/05315-3) awarded to
   A.T. Holkem, as well as the NSERC for the scholarship awarded to V.
   Robichaud.
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NR 51
TC 0
Z9 0
U1 4
U2 5
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2212-4292
EI 2212-4306
J9 FOOD BIOSCI
JI Food Biosci.
PD DEC
PY 2024
VL 62
AR 105354
DI 10.1016/j.fbio.2024.105354
EA OCT 2024
PG 9
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA K8T2I
UT WOS:001346559200001
DA 2025-06-11
ER

PT J
AU Maruyama-Fumoto, K
   McGuire, JJ
   Fairlie, DP
   Shinozuka, K
   Kagota, S
AF Maruyama-Fumoto, Kana
   McGuire, John J.
   Fairlie, David P.
   Shinozuka, Kazumasa
   Kagota, Satomi
TI Activation of protease-activated receptor 2 is associated with blood
   pressure regulation and proteinuria reduction in metabolic syndrome
SO CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
LA English
DT Article
DE metabolic syndrome; protease&#8208; activated receptor&#8208; 2;
   proteinuria; renal artery; vasorelaxation
ID DIET-INDUCED OBESITY; ANIMAL-MODEL; SHRSP.Z-LEPR(FA)/IZMDMCR RATS;
   CORONARY VASODILATION; STRESS; INFLAMMATION; TELMISARTAN; ANTAGONISM;
   MECHANISMS; EXPRESSION
AB Metabolic syndrome (MetS) increases the risk of kidney disease. In SHRSP.Z-Lepr(fa)/IzmDmcr (SHRSP.ZF) rats with MetS, protease-activated receptor 2 (PAR2)-mediated vasorelaxation is preserved in the aorta at 20 weeks of age (weeks) via enhancement of nitric oxide production but impaired at 30 weeks by oxidative stress. However, impairment of PAR2-mediated vasorelaxation of renal arteries and its possible implications for kidney disease are unclear. We used organ baths to assess PAR2-mediated vasorelaxation of isolated renal arteries, colorimetric methods to measure urinary protein levels as an index of renal function, and western blot to determine expression of PAR2 and nephrin proteins in the kidneys of SHRSP.ZF rats at 10, 20, and 30 weeks. We assessed renal arteries and kidney function for effects of orally administered GB88, a pathway-dependent PAR2 antagonist, from 10 to 18 weeks, and azilsartan, an angiotensin II type 1 receptor blocker, from 13 to 23 weeks. PAR2-mediated vasorelaxation was slightly lower at 20 weeks and attenuated significantly at 30 weeks compared with those at 10 weeks. Urinary protein levels were increased at 20 and 30 weeks. Decreased protein expression of PAR2 and nephrin in the kidney were observed at 30 weeks. Administration of GB88 increased blood pressure (BP) and proteinuria. Azilsartan reduced the high BP and the impaired PAR2-mediated vasorelaxation, but did not restore the increase in urinary protein levels and decreased PAR2 and nephrin protein expression in the kidney. PAR2 activation in the kidney may be associated with maintenance of BP and urinary protein excretion in MetS.
C1 [Maruyama-Fumoto, Kana; Shinozuka, Kazumasa; Kagota, Satomi] Mukogawa Womens Univ, Sch Pharm & Pharmaceut Sci, Dept Pharmacol 2, 11-68 Koshien Kyubancho, Nishinomiya, Hyogo 6638179, Japan.
   [McGuire, John J.] Western Univ, Schulich Sch Med & Dent, Dept Med Biophys, London, ON, Canada.
   [Fairlie, David P.] Univ Queensland, Inst Mol Biosci, Brisbane, Qld, Australia.
C3 Mukogawa Women's University; Western University (University of Western
   Ontario); University of Queensland
RP Kagota, S (corresponding author), Mukogawa Womens Univ, Sch Pharm & Pharmaceut Sci, Dept Pharmacol 2, 11-68 Koshien Kyubancho, Nishinomiya, Hyogo 6638179, Japan.
EM skagota@mukogawa-u.ac.jp
RI Fairlie, David/F-8865-2014
OI McGuire, John/0000-0003-0302-3884; Kagota, Satomi/0000-0003-2044-5552
FU NHMRC [1117017]; National Health and Medical Research Council of
   Australia [1117017] Funding Source: NHMRC
FX NHMRC, Grant/Award Number: a Senior Principal Research Fellowship
   (1117017)
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NR 42
TC 2
Z9 3
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0305-1870
EI 1440-1681
J9 CLIN EXP PHARMACOL P
JI Clin. Exp. Pharmacol. Physiol.
PD FEB
PY 2021
VL 48
IS 2
BP 211
EP 220
DI 10.1111/1440-1681.13431
EA NOV 2020
PG 10
WC Pharmacology & Pharmacy; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Physiology
GA PO4NO
UT WOS:000590815300001
PM 33124085
DA 2025-06-11
ER

PT S
AU Banhegyi, G
   Baumeister, P
   Benedetti, A
   Dong, D
   Fu, Y
   Lee, AS
   Li, J
   Mao, C
   Margittai, É
   Ni, M
   Paschen, W
   Piccirella, S
   Senesi, S
   Sitia, R
   Wang, M
   Yang, W
AF Banhegyi, Gabor
   Baumeister, Peter
   Benedetti, Angelo
   Dong, Dezheng
   Fu, Yong
   Lee, Amy S.
   Li, Jianze
   Mao, Changhui
   Margittai, Eva
   Ni, Min
   Paschen, Wulf
   Piccirella, Simona
   Senesi, Silvia
   Sitia, Roberto
   Wang, Miao
   Yang, Wei
BE Csermely, P
   Korcsmaros, T
   Sulyok, K
TI Endoplasmic reticulum stress
SO STRESS RESPONSES IN BIOLOGY AND MEDICINE: STRESS OF LIFE IN MOLECULES,
   CELLS, ORGANISMS, AND PSYCHOSOCIAL COMMUNITIES
SE Annals of the New York Academy of Sciences
LA English
DT Article; Proceedings Paper
CT 2nd World Conference on Stress
CY AUG 23-26, 2007
CL Budapest, HUNGARY
DE endoplasmic reticulum; stress; GRP78; cerebral ischemia; plasma cell;
   glucocorticoids; metabolic syndrome; obesity
ID UNFOLDED PROTEIN RESPONSE; 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1;
   MICROSOMAL GLUCOSE-6-PHOSPHATE TRANSLOCASE; TRANSIENT CEREBRAL-ISCHEMIA;
   GLUCOSE-REGULATED PROTEINS; MARINESCO-SJOGREN-SYNDROME; NEURONAL
   CELL-DEATH; HEXOSE-6-PHOSPHATE DEHYDROGENASE; TUMOR PROGRESSION; CALCIUM
   HOMEOSTASIS
AB Stress is the imbalance of homeostasis, which can be sensed even at the subcellular level. The stress-sensing capability of various organelles including the endoplasmic reticulum (ER) has been described. It has become evident that acute or prolonged ER stress plays an important role in many human diseases; especially those involving organs/tissues specialized in protein secretion. This article summarizes the emerging role of ER stress in diverse human pathophysiological conditions such as carcinogenesis and tumor progression, cerebral ischemia, plasma cell maturation and apoptosis, obesity, insulin resistance, and type 2 diabetes. Certain components of the ER stress response machinery are identified as biomarkers of the diseases or as possible targets for therapeutic intervention.
C1 Semmelweis Univ, Inst Med Chem Mol Biol & Pathobiochem, H-1088 Budapest, Hungary.
   Univ So Calif, Kenneth Norris Jr Comprehens Canc Ctr, Keck Sch Med, Los Angeles, CA 90033 USA.
   Univ So Calif, Dept Biochem & Mol Biol, Los Angeles, CA USA.
   Univ Siena, Dept Pathophysiol Expt Med & Publ Hlth, I-53100 Siena, Italy.
   Duke Univ, Med Ctr, Dept Anesthesiol, Multidisciplinary Neuroprotect Labs, Durham, NC 27710 USA.
   Duke Univ, Med Ctr, Dept Neurobiol, Multidisciplinary Neuroprotect Labs, Durham, NC 27710 USA.
   Univ Vita Salute San Raffaele, DiBiT Ist Sci San Raffaele, Milan, Italy.
C3 Semmelweis University; University of Southern California; University of
   Southern California; University of Siena; Duke University; Duke
   University; Vita-Salute San Raffaele University
RP Banhegyi, G (corresponding author), Semmelweis Univ, Inst Med Chem Mol Biol & Pathobiochem, Puskin Utca 9, H-1088 Budapest, Hungary.
EM banhegyi@puskin.sote.hu
RI Ni, Min/KIL-1395-2024; Sitia, Roberto/AAB-5005-2019; Bánhegyi,
   Gábor/A-1476-2014; Yang, Wei/C-6476-2008; Fu, Yong/A-4247-2012
OI Ni, Min/0000-0002-4587-1622; Fu, Yong/0000-0002-8423-8803; Sitia,
   Roberto/0000-0001-7086-4152; Lee, Amy/0000-0002-0378-5443
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NR 62
TC 146
Z9 157
U1 2
U2 45
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN STREET, MALDEN 02148, MA USA
SN 0077-8923
BN 978-1-57331-675-0
J9 ANN NY ACAD SCI
JI Ann.NY Acad.Sci.
PY 2007
VL 1113
BP 58
EP 71
DI 10.1196/annals.1391.007
PG 14
WC Psychology, Biological; Behavioral Sciences; Biochemistry & Molecular
   Biology; Immunology; Multidisciplinary Sciences; Psychology, Social
WE Conference Proceedings Citation Index - Science (CPCI-S); Conference Proceedings Citation Index - Social Science &amp; Humanities (CPCI-SSH); Science Citation Index Expanded (SCI-EXPANDED)
SC Psychology; Behavioral Sciences; Biochemistry & Molecular Biology;
   Immunology; Science & Technology - Other Topics
GA BGX56
UT WOS:000251158200006
PM 17483206
DA 2025-06-11
ER

PT J
AU Denisa, M
   Daniela, G
   Cristian, P
   Cimponeriu, D
   Maria, V
   Danciulescu, R
   Niculina, M
AF Denisa, Margina
   Daniela, Gradinaru
   Cristian, Panaite
   Cimponeriu, Danut
   Maria, Vladica
   Danciulescu, Ruxandra
   Niculina, Mitrea
TI The association of adipose tissue markers for redox imbalance and the
   cardio-vascular risk in obese patients
SO HEALTHMED
LA English
DT Article
DE lipid peroxidation; redox stress; obesity; cardio-vascular risk
ID METABOLIC SYNDROME; OXIDATIVE STRESS; ADIPONECTIN; DEFICIENCY
AB Introduction: Ectopic accumulation of lipids in peripheral tissues at obese patients, leads to lipotoxicity, process that contributes to the pathophysiology of cardio-vascular complications of obesity. The aim of the study was to establish the potential link between the markers used for the evaluation of the cardio-vascular risk measured at systemic level and the redox status assessed as the susceptibility of the white adipose tissue isolated through biopsy, to induced lipid peroxidation.
   Patients and methods: 15 patients with central obesity were selected; fasting blood samples were drawn for the biochemical evaluation. White adipose tissue was harvested from all the patients and homogenated in NaOH 0.015M, at 10% concentration. The tissue susceptibility to lipid peroxidation was non-enzymatically induced by incubation in a solution mixture with FeSO(4) and ascorbic acid in a 1:10 molar ratio; lipid peroxidation products were evaluated as TBARS.
   Results: The adipose tissue susceptibility to lipid peroxidation correlated significantly with the TC level and with the LDL level. Patients with impaired lipid profile were characterised by a significantly higher susceptibility of the adipose tissue to lipid peroxidation (p=0.036 compared to normolipidemic ones), associated with the decrease of the adiponectin level.
   Conclusion: The association of dyslipidemia with obesity is based on accelerated redox and inflammatory phenomena, localized at the adipose tissue level and represents probably the intermediate step before the constellation of risk factors that defines the metabolic syndrome. This pathological core (dyslipidemia and obesity) leads to a general metabolic imbalance, similar to that of metabolic syndrome patients. A better understanding of the molecular mechanisms that are activated in obesity will help identify new drug targets for its treatment.
C1 [Denisa, Margina; Daniela, Gradinaru; Niculina, Mitrea] Carol Davila Univ Med & Pharm, Fac Pharm, Dept Biochem, Bucharest, Romania.
   [Cristian, Panaite; Cimponeriu, Danut; Maria, Vladica; Danciulescu, Ruxandra] N Paulescu Natl Inst Diabet, Bucharest, Romania.
C3 Carol Davila University of Medicine & Pharmacy
RP Denisa, M (corresponding author), Carol Davila Univ Med & Pharm, Fac Pharm, Dept Biochem, Bucharest, Romania.
EM denisa.margina@gmail.com
RI Cimponeriu, Danut/AAT-4687-2021; Margina, Denisa/J-7312-2013
OI Margina, Denisa/0000-0003-3289-147X
FU National Agency for Scientific Research [41-067/2007 PN 2]
FX The work was supported by grant 41-067/2007 PN 2 of the National Agency
   for Scientific Research.
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NR 16
TC 7
Z9 7
U1 0
U2 2
PU DRUNPP-SARAJEVO
PI SARAJEVO
PA BOLNICKA BB, SARAJEVO, 71000, BOSNIA & HERCEG
SN 1840-2291
J9 HEALTHMED
JI HealthMED
PY 2011
VL 5
IS 1
BP 194
EP 199
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 727RT
UT WOS:000287819600026
DA 2025-06-11
ER

PT J
AU Spalm, FHP
   Sánchez, MLC
   Furland, NE
   Vallés, AS
AF Spalm, Facundo H. Prado H.
   Sanchez, Marie L. Cuervo
   Furland, Natalia E.
   Valles, Ana S.
TI Lipid peroxidation and neuroinflammation: A possible link between
   maternal fructose intake and delay of acquisition of neonatal reflexes
   in Wistar female rats
SO DEVELOPMENTAL NEUROBIOLOGY
LA English
DT Article
DE fructose; lipid peroxidation; metabolic syndrome; neurodevelopment;
   neuroinflammation; offspring
ID HIGH-FAT DIET; METABOLIC SYNDROME; OXIDATIVE STRESS; OBESITY;
   CONSUMPTION; BRAIN; INFLAMMATION; CHILDREN; FETAL; HYPERTENSION
AB Fructose is a common sweetener found in the daily diet supplemented to many processed and ultra-processed foods and beverages. Consumption of fructose-sweetened beverages has drastically increased in the last decades and is widely associated with metabolic disease, systemic pro-inflammatory status, and adverse transgenerational effects. To date, the impact of maternal fructose intake in brain function of the offspring is less explored. Therefore, the aim of this study was first, to investigate adverse effects in developmental milestones of the progeny of mothers with metabolic syndrome (MetS), induced by ad libitum consumption of a 20% fructose solution, and second to identify possible molecular changes in the nervous system of the newborns associated with maternal fructose intake. Wistar rats were randomly separated into two groups with access to water or fructose (20% w/v in water) for 10 weeks. After MetS was confirmed, dams were mated with control males and continued drinking water or fructose solution during gestation. At postnatal day (PN) 1, a subgroup of offspring of each sex was sacrificed and brains were dissected for oxidative stress and inflammatory status analysis. Changes in the developmental milestones due to maternal fructose consumption were studied (PN3-PN21) in another subgroup of offspring. Sexually dimorphic effects were found on the progeny's acquisition of neurodevelopmental milestones, in brain lipid peroxidation, neuroinflammation, and antioxidative defensive response. Our results suggest that dams' MetS, induced by fructose intake, disrupts brain redox homeostasis in female offspring and affects sensorimotor brain circuitry which may have a translational value for studying neurodevelopmental diseases.
C1 [Spalm, Facundo H. Prado H.; Sanchez, Marie L. Cuervo; Furland, Natalia E.; Valles, Ana S.] INIBIBB CONICET UNS, Nutr & Neurodev Lab, Bahia Blanca, Argentina.
   [Valles, Ana S.] INIBIBB CONICET UNS, Nutr & Neurodev Lab, Camino Carrindanga Km 7, RA-8000 Bahia Blanca, Buenos Aires, Argentina.
RP Vallés, AS (corresponding author), INIBIBB CONICET UNS, Nutr & Neurodev Lab, Camino Carrindanga Km 7, RA-8000 Bahia Blanca, Buenos Aires, Argentina.
EM sofiavalles@gmail.com
RI Vallés, Ana/GVU-5374-2022
OI Prado Spalm, Facundo Heber/0009-0008-5163-8756
FU Consejo Nacional de Investigaciones Cientificas y Tecnicas
   [PUE22920170100017CO]; Agencia Nacional de Promocion de la Ciencia y la
   Tecnologia [PICT2018-01182]; Universidad Nacional del Sur [PGI 24/B311,
   PGI24/B76, PGI24/B302]
FX Consejo Nacional de Investigaciones Cientificas y Tecnicas, Grant/Award
   Number: PUE22920170100017CO; Agencia Nacional de Promocion de la Ciencia
   y la Tecnologia, Grant/Award Number: PICT2018-01182; Universidad
   Nacional del Sur, Grant/Award Numbers: PGI 24/B311, PGI24/B76,
   PGI24/B302
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NR 93
TC 2
Z9 2
U1 2
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1932-8451
EI 1932-846X
J9 DEV NEUROBIOL
JI Dev. Neurobiol.
PD JUL
PY 2023
VL 83
IS 5-6
BP 167
EP 183
DI 10.1002/dneu.22921
EA JUL 2023
PG 17
WC Developmental Biology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Developmental Biology; Neurosciences & Neurology
GA R8LD1
UT WOS:001026906700001
PM 37435772
OA Bronze
DA 2025-06-11
ER

PT J
AU Zakariaa, EM
   Abdel-Ghanya, RH
   Elgharbawya, AS
   Alsemeh, AE
   Metwallya, SS
AF Zakariaa, Esraa M.
   Abdel-Ghanya, Rasha H.
   Elgharbawya, Atef S.
   Alsemeh, Amira Ebrahim
   Metwallya, Sami S.
TI A novel approach to repositioning memantine for metabolic
   syndrome-induced steatohepatitis: Modulation of hepatic autophagy,
   inflammation, and fibrosis
SO LIFE SCIENCES
LA English
DT Article
DE Memantine; Nonalcoholic steatohepatitis; Hepatic autophagy; Metabolic
   syndrome; Oxidative stress; Pioglitazone
ID FATTY LIVER-DISEASE; OXIDATIVE STRESS; OBESITY; PIOGLITAZONE; RECEPTORS;
   SYSTEM; RATS; DIET
AB Aims: This study investigated the possible hepatoprotective effects of memantine, compared to pioglitazone, in rat steatohepatitis, emphasizing its role in modulating hepatic autophagy.Main methods: Metabolic syndrome (MetS) was provoked in adult male Wistar rats by a high fructose/fat/salt regimen for eight weeks. Then, rats were administered either memantine or pioglitazone daily for 10 weeks (both at 20 mg/kg, orally). An oral glucose tolerance test (OGTT) was done at the end of the study, and serum liver enzymes, lipids, and fasting blood glucose were measured. Also, hepatic contents of inflammatory, oxidative, and autophagy markers were quantified. Additionally, histopathological examinations of general hepatic structure and glycogen content were performed.Key findings: Compared to the MetS rats, memantine normalized fasting serum insulin, Homeostatic Model Assessment (HOMA-IR), serum lipids, and liver enzymes (ALT and AST). Memantine also markedly reduced hepatic inflammatory markers; NF-kappa B and TNF-alpha. In addition, hepatic NRF2 and GSH were augmented, while hepatic MDA was reduced by memantine. Interestingly, livers of the memantine group showed elevated Beclin1 and LC3 and reduced p62 contents compared to the MetS group indicating that memantine preserved hepatic autophagy. Histopathological examination revealed that memantine ameliorated hepatic steatosis and inflam-mation. Pioglitazone also mitigated most of the steatohepatitis-related changes, however, memantine was more effective in most of the studied parameters.Significance: The hepatoprotective effect of memantine against steatohepatitis is mediated, at least partly, through conserving hepatic autophagy along with anti-inflammatory, antioxidant, and anti-fibrotic effects.
C1 [Zakariaa, Esraa M.; Abdel-Ghanya, Rasha H.; Elgharbawya, Atef S.; Metwallya, Sami S.] Zagazig Univ, Fac Pharm, Dept Pharmacol & Toxicol, Zagazig 44519, Egypt.
   [Alsemeh, Amira Ebrahim] Zagazig Univ, Fac Med, Dept Anat, Zagazig 44519, Egypt.
C3 Egyptian Knowledge Bank (EKB); Zagazig University; Egyptian Knowledge
   Bank (EKB); Zagazig University
RP Zakariaa, EM (corresponding author), Zagazig Univ, Fac Pharm, Dept Pharmacol & Toxicol, Zagazig 44519, Egypt.
EM emzakaria@zu.edu.eg
RI Zakaria, Esraa Mohammed Naguib/GYD-7862-2022; Alsemeh,
   Amira/LWH-9728-2024
OI , Esraa M Zakaria/0000-0002-1132-2254; Salah, Sami/0009-0009-1767-3897
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NR 65
TC 3
Z9 3
U1 0
U2 7
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0024-3205
EI 1879-0631
J9 LIFE SCI
JI Life Sci.
PD APR 15
PY 2023
VL 319
AR 121509
DI 10.1016/j.lfs.2023.121509
EA MAR 2023
PG 12
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA 0A0NA
UT WOS:000951525700001
PM 36822316
DA 2025-06-11
ER

PT J
AU Swiatkiewicz, I
   Mila-Kierzenkowska, C
   Wozniak, A
   Szewczyk-Golec, K
   Nuszkiewicz, J
   Wróblewska, J
   Rajewski, P
   Eussen, SJPM
   Færch, K
   Manoogian, ENC
   Panda, S
   Taub, PR
AF Swiatkiewicz, Iwona
   Mila-Kierzenkowska, Celestyna
   Wozniak, Alina
   Szewczyk-Golec, Karolina
   Nuszkiewicz, Jaroslaw
   Wroblewska, Joanna
   Rajewski, Pawel
   Eussen, Simone J. P. M.
   Faerch, Kristine
   Manoogian, Emily N. C.
   Panda, Satchidananda
   Taub, Pam R.
TI Pilot Clinical Trial of Time-Restricted Eating in Patients with
   Metabolic Syndrome
SO NUTRIENTS
LA English
DT Article
DE time-restricted eating; metabolic syndrome; eating pattern; clinical
   trial; m-health applications; cardiometabolic risks; health outcomes;
   body weight; circadian rhythm; dietary assessment methodologies
AB Metabolic syndrome (MetS) and erratic eating patterns are associated with circadian rhythm disruption which contributes to an increased cardiometabolic risks. Restricting eating period (time-restricted eating, TRE) can restore robust circadian rhythms and improve cardiometabolic health. We describe a protocol of the Time-Restricted Eating on Metabolic and Neuroendocrine homeostasis, Inflammation, and Oxidative Stress (TREMNIOS) pilot clinical trial in Polish adult patients with MetS and eating period of >= 14 h/day. The study aims to test the feasibility of TRE intervention and methodology for evaluating its efficacy for improving metabolic, neuroendocrine, inflammatory, oxidative stress and cardiac biomarkers, and daily rhythms of behavior for such population. Participants will apply 10-h TRE over a 12-week monitored intervention followed by a 12-week self-directed intervention. Changes in eating window, body weight and composition, biomarkers, and rhythms of behavior will be evaluated. Dietary intake, sleep, activity and wellbeing will be monitored with the myCircadianClock application and questionnaires. Adherence to TRE defined as the proportion of days recorded with app during the monitored intervention in which participants satisfied 10-h TRE is the primary outcome. TREMNIOS will also provide an exploratory framework to depict post-TRE changes in cardiometabolic outcomes and behavior rhythms. This protocol extends previous TRE-related protocols by targeting European population with diagnosed MetS and including long-term intervention, validated tools for monitoring dietary intake and adherence, and comprehensive range of biomarkers. TREMNIOS trial will lay the groundwork for a large-scale randomized controlled trial to determine TRE efficacy for improving cardiometabolic health in MetS population.
C1 [Swiatkiewicz, Iwona] Nicolaus Copernicus Univ, Coll Med, Dept Cardiol & Internal Med, PL-85094 Bydgoszcz, Poland.
   [Swiatkiewicz, Iwona; Taub, Pam R.] Univ Calif San Diego, Div Cardiovasc Med, La Jolla, CA 92037 USA.
   [Mila-Kierzenkowska, Celestyna; Wozniak, Alina; Szewczyk-Golec, Karolina; Nuszkiewicz, Jaroslaw; Wroblewska, Joanna] Nicolaus Copernicus Univ, Coll Med, Dept Med Biol & Biochem, PL-85092 Bydgoszcz, Poland.
   [Rajewski, Pawel] Ctr Obes & Metab Disorders Treatment, PL-85676 Bydgoszcz, Poland.
   [Eussen, Simone J. P. M.] Maastricht Univ, Dept Epidemiol, NL-6200 MD Maastricht, Netherlands.
   [Eussen, Simone J. P. M.] Maastricht Univ, Sch Cardiovasc Dis CARIM, NL-6200 MD Maastricht, Netherlands.
   [Faerch, Kristine] Steno Diabet Ctr Copenhagen, DK-2820 Gentofte, Denmark.
   [Faerch, Kristine] Univ Copenhagen, Dept Biomed Sci, DK-2200 Copenhagen, Denmark.
   [Manoogian, Emily N. C.; Panda, Satchidananda] Salk Inst Biol Studies, La Jolla, CA 92037 USA.
C3 Nicolaus Copernicus University; University of California System;
   University of California San Diego; Nicolaus Copernicus University;
   Maastricht University; Maastricht University; Steno Diabetes Center;
   University of Copenhagen; Salk Institute
RP Swiatkiewicz, I (corresponding author), Nicolaus Copernicus Univ, Coll Med, Dept Cardiol & Internal Med, PL-85094 Bydgoszcz, Poland.; Swiatkiewicz, I (corresponding author), Univ Calif San Diego, Div Cardiovasc Med, La Jolla, CA 92037 USA.
EM iwona.swiatkiewicz@gmail.com; celestyna@o2.pl; alina-wozniak@wp.pl;
   karosz@cm.umk.pl; jnuszkiewicz@cm.umk.pl; jwroblewskapraca@gmail.com;
   rajson@wp.pl; simone.eussen@maastrichtuniversity.nl;
   kristine.faerch@regionh.dk; emily.manoogian@gmail.com; panda@salk.edu;
   ptaub@health.ucsd.edu
RI Wróblewska, Joanna/G-8607-2014; Mila-Kierzenkowska,
   Celestyna/F-1858-2014; eussen, simone/JAC-5744-2023; Swiatkiewicz,
   Iwona/H-4279-2014; Szewczyk-Golec, Karolina/E-9110-2014; Wozniak,
   Alina/H-4699-2014; Nuszkiewicz, Jaroslaw/AAI-6787-2021
OI Faerch, Kristine/0000-0002-6127-0448; Taub, Pam/0000-0002-0684-0655;
   Manoogian, Emily Nicole/0000-0001-9718-9310; Rajewski,
   Pawel/0000-0001-9796-8840; Szewczyk-Golec, Karolina/0000-0001-8123-3882;
   Wozniak, Alina/0000-0002-4492-4796; Wroblewska,
   Joanna/0000-0002-8188-8296; Nuszkiewicz, Jaroslaw/0000-0003-1378-5065;
   Eussen, Simone/0000-0003-0559-6838
FU Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland
FX The study is funded by Collegium Medicum, Nicolaus Copernicus
   University, Bydgoszcz, Poland. This research received no external
   funding.
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NR 65
TC 15
Z9 16
U1 0
U2 12
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD FEB
PY 2021
VL 13
IS 2
AR 346
DI 10.3390/nu13020346
PG 18
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA QO1LZ
UT WOS:000622909600001
PM 33498955
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU June, RK
   Liu-Bryan, R
   Long, FX
   Griffin, TM
AF June, Ronald K.
   Liu-Bryan, Ru
   Long, Fanxing
   Griffin, Timothy M.
TI Emerging role of metabolic signaling in synovial joint remodeling and
   osteoarthritis
SO JOURNAL OF ORTHOPAEDIC RESEARCH
LA English
DT Review
DE metabolic syndrome; obesity; bone; cartilage; osteoarthritis
ID ACTIVATED PROTEIN-KINASE; ENDOPLASMIC-RETICULUM STRESS; RADIOGRAPHIC
   KNEE OSTEOARTHRITIS; MITOCHONDRIAL DYSFUNCTION; CATABOLIC RESPONSES;
   GENE-EXPRESSION; ADIPOSE-TISSUE; LIFETIME RISK; NITRIC-OXIDE; OBESITY
AB Obesity and associated metabolic diseases collectively referred to as the metabolic syndrome increase the risk of skeletal and synovial joint diseases, including osteoarthritis (OA). The relationship between obesity and musculoskeletal diseases is complex, involving biomechanical, dietary, genetic, inflammatory, and metabolic factors. Recent findings illustrate how changes in cellular metabolism and metabolic signaling pathways alter skeletal development, remodeling, and homeostasis, especially in response to biomechanical and inflammatory stressors. Consequently, a better understanding of the energy metabolism of diarthrodial joint cells and tissues, including bone, cartilage, and synovium, may lead to new strategies to treat or prevent synovial joint diseases such as OA. This rationale was the basis of a workshop presented at the 2016 Annual ORS Meeting in Orlando, FL on the emerging role of metabolic signaling in synovial joint remodeling and OA. The topics we covered included (i) the relationship between metabolic syndrome and OA in clinical and pre-clinical studies; (ii) the effect of biomechanical loading on chondrocyte metabolism; (iii) the effect of Wnt signaling on osteoblast carbohydrate and amino acid metabolism with respect to bone anabolism; and (iv) the role of AMP-activated protein kinase in chondrocyte energetic and biomechanical stress responses in the context of cartilage injury, aging, and OA. Although challenges exist for measuring in vivo changes in synovial joint tissue metabolism, the findings presented herein provide multiple lines of evidence to support a central role for disrupted cellular energy metabolism in the pathogenesis of OA. (c) 2016 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 34:2048-2058, 2016.
C1 [June, Ronald K.] Montana State Univ, Dept Mech & Ind Engn, POB 173800, Bozeman, MT 59717 USA.
   [June, Ronald K.] Montana State Univ, Dept Cell Biol & Neurosci, POB 173800, Bozeman, MT 59717 USA.
   [Liu-Bryan, Ru] Univ Calif San Diego, Dept Med, VA San Diego Healthcare Syst, San Diego, CA 92103 USA.
   [Long, Fanxing] Washington Univ, Sch Med, Dept Dev Biol, Dept Orthopaed Surg, St Louis, MO USA.
   [Griffin, Timothy M.] Oklahoma Med Res Fdn, Aging & Metab Res Program, 825 NE 13th St,MS 21, Oklahoma City, OK 73104 USA.
   [Griffin, Timothy M.] Univ Oklahoma, Hlth Sci Ctr, Dept Biochem & Mol Biol, 825 NE 13th St,MS 21, Oklahoma City, OK 73104 USA.
   [Griffin, Timothy M.] Univ Oklahoma, Hlth Sci Ctr, Dept Physiol, 825 NE 13th St,MS 21, Oklahoma City, OK 73104 USA.
   [Griffin, Timothy M.] Univ Oklahoma, Hlth Sci Ctr, Dept Geriatr Med, 825 NE 13th St,MS 21, Oklahoma City, OK 73104 USA.
C3 Montana State University System; Montana State University Bozeman;
   Montana State University System; Montana State University Bozeman;
   University of California System; University of California San Diego; US
   Department of Veterans Affairs; Veterans Health Administration (VHA); VA
   San Diego Healthcare System; Washington University (WUSTL); Oklahoma
   Medical Research Foundation; University of Oklahoma System; University
   of Oklahoma Health Sciences Center; University of Oklahoma System;
   University of Oklahoma Health Sciences Center; University of Oklahoma
   System; University of Oklahoma Health Sciences Center
RP June, RK (corresponding author), Montana State Univ, Dept Mech & Ind Engn, POB 173800, Bozeman, MT 59717 USA.; June, RK (corresponding author), Montana State Univ, Dept Cell Biol & Neurosci, POB 173800, Bozeman, MT 59717 USA.; Griffin, TM (corresponding author), Oklahoma Med Res Fdn, Aging & Metab Res Program, 825 NE 13th St,MS 21, Oklahoma City, OK 73104 USA.; Griffin, TM (corresponding author), Univ Oklahoma, Hlth Sci Ctr, Dept Biochem & Mol Biol, 825 NE 13th St,MS 21, Oklahoma City, OK 73104 USA.; Griffin, TM (corresponding author), Univ Oklahoma, Hlth Sci Ctr, Dept Physiol, 825 NE 13th St,MS 21, Oklahoma City, OK 73104 USA.; Griffin, TM (corresponding author), Univ Oklahoma, Hlth Sci Ctr, Dept Geriatr Med, 825 NE 13th St,MS 21, Oklahoma City, OK 73104 USA.
EM rjune@montana.edu; tim-griffin@omrf.org
RI Griffin, Timothy/V-8838-2019
FU National Institute of Arthritis and Musculoskeletal and Skin Diseases
   [R01 AR060456, AR055923, R01AR1067966, R03AR066828]; National Institute
   on Aging [R01AG049058]; Department of Veterans Affairs [1I01BX002234];
   Arthritis Foundation [6045]; National Science Foundation [1342420,
   1554708]; Div Of Civil, Mechanical, & Manufact Inn; Directorate For
   Engineering [1342420, 1554708] Funding Source: National Science
   Foundation
FX Grant sponsor: National Institute of Arthritis and Musculoskeletal and
   Skin Diseases; Grant numbers: R01 AR060456, AR055923, R01AR1067966,
   R03AR066828; Grant sponsor: National Institute on Aging; Grant number:
   R01AG049058; Grant sponsor: Department of Veterans Affairs; Grant
   number: 1I01BX002234; Grant sponsor: Arthritis Foundation; Grant number:
   6045; Grant sponsor: National Science Foundation; Grant numbers:
   1342420, 1554708.
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NR 105
TC 62
Z9 69
U1 0
U2 12
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0736-0266
EI 1554-527X
J9 J ORTHOP RES
JI J. Orthop. Res.
PD DEC
PY 2016
VL 34
IS 12
BP 2048
EP 2058
DI 10.1002/jor.23420
PG 11
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA EI5LQ
UT WOS:000392536500004
PM 27605370
OA Bronze, Green Accepted
DA 2025-06-11
ER

PT J
AU Alosaimi, FD
   Abalhassan, MF
   Alhabbad, AA
   Fallata, EO
   Haddad, BA
   AlQattan, NI
   Alassiry, MZ
AF Alosaimi, Fahad D.
   Abalhassan, Mohammed F.
   Alhabbad, Abdulhadi A.
   Fallata, Ebtihaj O.
   Haddad, Bander A.
   AlQattan, Nada, I
   Alassiry, Mohammed Z.
TI Prevalence and determinants of physical activity in a mixed sample of
   psychiatric patients in Saudi Arabia
SO SAUDI MEDICAL JOURNAL
LA English
DT Article
ID SEVERE MENTAL-ILLNESS; SEDENTARY BEHAVIOR; METABOLIC SYNDROME; ANXIETY
   DISORDERS; BIPOLAR DISORDER; ALL-CAUSE; EXERCISE; DEPRESSION;
   ASSOCIATION; MORTALITY
AB Objectives: To estimate prevalence of physical activity and its associations with various psychiatric disorders and the use of psychotropic medications.
   Methods: A cross-sectional observational study was carried out between July 2012 and June 2014. Patients were enrolled from a number of hospitals located in 5 regions of the Kingdom of Saudi Arabia.
   Results: A total of 1185 patients were included in current analysis: 796 were outpatients, and 389 were inpatients. Out of 1,185 patients, 153 (12.9%) were physically active. Much higher rates of physical activity were reported among males than females (15.9% versus 9.6%, p<0.001). According to the univariate analysis, higher rates of physical activity were positively correlated with primary bipolar disorders, the use of antianxiety medications and, to a lesser extent, use of antipsychotic medications, but they were negatively correlated with primary anxiety disorders, use of antidepressant medications, and use of multiple psychotropic medications. The associations between physical activity and primary bipolar disorders (odds ratio [OR]=2.47, p=0.002), use of antianxiety medications (OR=3.58, p=0.003), and use of multiple psychotropic medications (OR=0.33, p<0.001) remained significant after adjusting for demographic and clinical characteristics.
   Conclusion: We report a variable but generally low prevalence of physical activity among a large, mixed sample of psychiatric patients in Saudi Arabia. These findings may highlight the importance of assessing physical activity status of psychiatric patients and the critical need for physical activity promotion programs among this group of disadvantaged patients.
C1 [Alosaimi, Fahad D.] King Saud Univ, Dept Psychiat, Riyadh, Saudi Arabia.
   [Haddad, Bander A.] Al Imam Mohammad Bin Saud Univ, Dept Neurosci, Riyadh, Saudi Arabia.
   [Abalhassan, Mohammed F.] Prince Sattam Bin Abdulaziz Univ, Dept Med, Alkharj, Saudi Arabia.
   [Alhabbad, Abdulhadi A.] Prince Mohammed Med City, Dept Psychiat, Aljoafi, Saudi Arabia.
   [Fallata, Ebtihaj O.] Mental Hlth Hosp, Dept Psychiat, Jeddah, Saudi Arabia.
   [Alassiry, Mohammed Z.] Mental Hlth Hosp, Dept Psychiat, Abha, Saudi Arabia.
   [AlQattan, Nada, I] Al Amal Complex Mental Hlth, Dept Psychiat, Dammam, Saudi Arabia.
C3 King Saud University; Imam Mohammad Ibn Saud Islamic University (IMSIU);
   Prince Sattam Bin Abdulaziz University; Prince Mohammed Medical City
RP Alosaimi, FD (corresponding author), King Saud Univ, Dept Psychiat, Riyadh, Saudi Arabia.
EM dr.fahad.alosaimi@gmail.com
RI Alosaimi, Fahad/JDW-3312-2023
OI Alosaimi, Fahad/0000-0003-1027-5836
FU College of Medicine Research Center, Deanship of Scientific Research,
   King Saud University
FX The authors extend their sincere appreciation for the support they
   received from the College of Medicine Research Center, Deanship of
   Scientific Research, King Saud University. The authors also express
   their gratitude to Ms. Fatima Jama and Dr. Aiman El-Saed for their
   assistance with data entry and analysis, respectively.
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NR 50
TC 5
Z9 5
U1 0
U2 5
PU SAUDI MED J
PI RIYADH
PA ARMED FORCES HOSPITAL, PO BOX 7897,, RIYADH 11159, SAUDI ARABIA
SN 0379-5284
J9 SAUDI MED J
JI Saudi Med. J.
PD APR
PY 2018
VL 39
IS 4
BP 400
EP 410
DI 10.15537/smj.2018.4.21796
PG 11
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA GQ0PT
UT WOS:000441322400012
PM 29619493
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Matsuura, N
   Asano, C
   Nagasawa, K
   Ito, S
   Sano, Y
   Minagawa, Y
   Yamada, Y
   Hattori, T
   Watanabe, S
   Murohara, T
   Nagata, K
AF Matsuura, Natsumi
   Asano, Chiharu
   Nagasawa, Kai
   Ito, Shogo
   Sano, Yusuke
   Minagawa, Yuji
   Yamada, Yuichiro
   Hattori, Takuya
   Watanabe, Shogo
   Murohara, Toyoaki
   Nagata, Kohzo
TI Effects of pioglitazone on cardiac and adipose tissue pathology in rats
   with metabolic syndrome
SO INTERNATIONAL JOURNAL OF CARDIOLOGY
LA English
DT Article
DE Metabolic syndrome; Thiazolidinedione; Cardiac remodeling; Inflammation;
   Adipose tissue; Glucose metabolism
ID NECROSIS-FACTOR-ALPHA; ACTIVATED PROTEIN-KINASE; HEART-FAILURE;
   INSULIN-RESISTANCE; ANIMAL-MODEL; DAHLS.Z-LEPR(FA)/LEPR(FA) RATS;
   OXIDATIVE STRESS; GENE-EXPRESSION; NADPH OXIDASE; FOOD-INTAKE
AB Background: Pioglitazone is a thiazolidinedione drug that acts as an insulin sensitizer. We recently characterized DahlS. Z-Lepr(fa)/Lepr(fa) (DS/obese) rats, derived from a cross between Dahl salt-sensitive and Zucker rats, as a new animal model of metabolic syndrome. We have now investigated the effects of pioglitazone on cardiac and adipose tissue pathology in this model.
   Methods and results: DS/obese rats were treated with pioglitazone (2.5 mg/kg per day, per os) from 9 to 13 weeks of age. Age-matched homozygous lean (DahlS. Z-Lepr(+)/Lepr(+), or DS/lean) littermates served as controls. Pioglitazone increased body weight and food intake in DS/obese rats. It also ameliorated left ventricular (LV) hypertrophy, fibrosis, and diastolic dysfunction as well as attenuated cardiac oxidative stress and inflammation, without lowering blood pressure, in DS/obese rats, but it had no effect on these parameters in DS/lean rats. In addition, pioglitazone increased visceral and subcutaneous fat mass but alleviated adipocyte hypertrophy and inflammation in visceral adipose tissue in DS/obese rats. Furthermore, pioglitazone increased the serum concentration of adiponectin, induced activation of AMP-activated protein kinase (AMPK) in the heart, as well as ameliorated glucose intolerance and insulin resistance in DS/obese rats.
   Conclusions: Treatment of DS/obese rats with pioglitazone exacerbated obesity but attenuated LV hypertrophy, fibrosis, and diastolic dysfunction, with these latter effects being associated with the activation of cardiac AMPK signaling likely as a result of the stimulation of adiponectin secretion. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
C1 [Matsuura, Natsumi; Nagasawa, Kai; Ito, Shogo; Sano, Yusuke; Yamada, Yuichiro; Hattori, Takuya; Watanabe, Shogo; Nagata, Kohzo] Nagoya Univ, Grad Sch Med, Dept Pathophysiol Lab Sci, Nagoya, Aichi 4618673, Japan.
   [Asano, Chiharu; Minagawa, Yuji] Nagoya Univ, Sch Hlth Sci, Dept Med Technol, Nagoya, Aichi 4618673, Japan.
   [Murohara, Toyoaki] Nagoya Univ, Grad Sch Med, Dept Cardiol, Nagoya, Aichi 4618673, Japan.
C3 Nagoya University; Nagoya University; Nagoya University
RP Nagata, K (corresponding author), Nagoya Univ, Grad Sch Med, Dept Pathophysiol Lab Sci, Higashi Ku, 1-1-20 Daikominami, Nagoya, Aichi 4618673, Japan.
EM nagata@met.nagoya-u.ac.jp
RI Murohara, Toyoaki/M-4958-2014
FU Kyowa Hakko Kirin Co. Ltd. (Tokyo, Japan); Ajinomoto Pharmaceuticals
   Co., Ltd. (Tokyo, Japan); Astellas Pharma Inc. (Tokyo, Japan); Mochida
   Pharmaceutical Co., Ltd. (Tokyo, Japan); Mitsubishi Tanabe Pharma
   Corporation (Osaka, Japan); Takeda Pharmaceutical Company Limited
   (Osaka, Japan); Daiichi-Sankyo Company, Limited (Tokyo, Japan); Japanese
   government
FX This study was supported by unrestricted research grants from Kyowa
   Hakko Kirin Co. Ltd. (Tokyo, Japan), Ajinomoto Pharmaceuticals Co., Ltd.
   (Tokyo, Japan), Astellas Pharma Inc. (Tokyo, Japan), Mochida
   Pharmaceutical Co., Ltd. (Tokyo, Japan), Mitsubishi Tanabe Pharma
   Corporation (Osaka, Japan), Takeda Pharmaceutical Company Limited
   (Osaka, Japan), Daiichi-Sankyo Company, Limited (Tokyo, Japan) and Dr.
   Nagata (Nagoya University) as well as by Management Expenses Grants from
   the Japanese government to Nagoya University.
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NR 54
TC 41
Z9 42
U1 1
U2 9
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0167-5273
EI 1874-1754
J9 INT J CARDIOL
JI Int. J. Cardiol.
PD JAN 20
PY 2015
VL 179
BP 360
EP 369
DI 10.1016/j.ijcard.2014.11.099
PG 10
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA AW2AC
UT WOS:000346089400099
PM 25464487
DA 2025-06-11
ER

PT J
AU Bradley, R
   Fitzpatrick, AL
   Jenny, NS
   Lee, DH
   Jacobs, DR
AF Bradley, Ryan
   Fitzpatrick, Annette L.
   Jenny, Nancy S.
   Lee, Duk-Hee
   Jacobs, David R., Jr.
TI Associations between total serum GGT activity and metabolic risk: MESA
SO BIOMARKERS IN MEDICINE
LA English
DT Article
DE gamma-glutamyltransferase; GGT; glutathione; metabolic syndrome;
   oxidative stress; Type 2 diabetes
ID GAMMA-GLUTAMYL-TRANSFERASE; OXIDATIVE STRESS; ALANINE AMINOTRANSFERASE;
   INSULIN-RESISTANCE; HEALTHY-MEN; BETA-CELL; PLASMA; HEART;
   TRANSPEPTIDASE; GLUTATHIONE
AB Aim: To evaluate associations between total serum GGT activity, metabolic risk factors and prevalent metabolic disease in MESA. Patients & methods: Continuous associations between GGT and fasting blood glucose (FBG), fasting insulin, HbA(1c) and Homeostasis Model Assessment Index of Insulin Resistance (HOMA-IR) were evaluated in the entire MESA cohort and in metabolic disease subgroups using linear regression models incrementally adjusted for age, gender, site, race, lifestyle, traditional risk factors and medications. Cross-sectional odds of prevalent impaired FBG, metabolic syndrome and Type 2 diabetes were calculated for GGT quintiles in the entire cohort and in subgroups defined by age (< or 65 years) and ethnicity. Results: In multivariable models, significant associations were present between GGT activity and FBG, fasting insulin, HbA(1c) and HOMA-IR, with the interaction between GGT and BMI affecting the association between GGT and HOMA-IR as well as the association between BMI and HOMA-IR (p < 0.0001). Adjusted odds ratios (95% CIs) of prevalent impaired FBG, metabolic syndrome and Type 2 diabetes for quintile 5 versus 1 in the entire cohort were 2.4 (1.7-3.5), 3.3 (2.5-4.5) and 2.8 (1.8-4.4), respectively (p < 0.0001). GGT associations weakened with age. The significance of linear trends for increased prevalent metabolic disease by increasing GGT quintile varied by ethnicity. Conclusion: GGT is strongly associated with both cardiovascular and metabolic risk factors, including prevalent metabolic disease, in the MESA cohort.
C1 [Bradley, Ryan] Bastyr Univ, Res Inst, San Diego, CA 92121 USA.
   [Fitzpatrick, Annette L.] Univ Washington, Seattle, WA 98155 USA.
   [Jenny, Nancy S.] Univ Vermont, Coll Med, Lab Clin Biochem Res, Colchester, VT 05446 USA.
   [Lee, Duk-Hee] Kyungpook Natl Univ, Sch Med, Taegu 700842, South Korea.
   [Jacobs, David R., Jr.] Univ Minnesota, Div Epidemiol & Community Hlth, Minneapolis, MN 55454 USA.
C3 University of Washington; University of Washington Seattle; University
   of Vermont; Kyungpook National University (KNU); University of Minnesota
   System; University of Minnesota Twin Cities
RP Bradley, R (corresponding author), Bastyr Univ, Res Inst, 4106 Sorrento Valley Blvd, San Diego, CA 92121 USA.
EM rbradley@bastyr.edu
RI Jacobs, David/G-5405-2011
OI Jacobs, David/0000-0002-7232-0543
FU National Heart, Lung and Blood Institute [N01-HC-95159-95166]; National
   Center for Research Resources [1KL2RR025015]
FX This research was made possible by contracts N01-HC-95159-95166 from the
   National Heart, Lung and Blood Institute, and 1KL2RR025015 from the
   National Center for Research Resources. The authors have no other
   relevant affiliations or financial involvement with any organization or
   entity with a financial interest in or financial conflict with the
   subject matter or materials discussed in the manuscript apart from those
   disclosed.
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NR 43
TC 24
Z9 27
U1 1
U2 16
PU FUTURE MEDICINE LTD
PI LONDON
PA UNITEC HOUSE, 3RD FLOOR, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON, N3
   1QB, ENGLAND
SN 1752-0363
EI 1752-0371
J9 BIOMARK MED
JI Biomark. Med.
PD OCT
PY 2013
VL 7
IS 5
BP 709
EP 721
DI 10.2217/bmm.13.71
PG 13
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 219AF
UT WOS:000324474800011
PM 24044563
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Li, N
   Wang, R
   Hu, PH
   Lu, WT
   Zhao, XC
   Wang, L
   Song, M
   Gao, YY
   An, CX
   Bashir, S
   Wang, XY
AF Li, Na
   Wang, Ran
   Hu, Peihua
   Lu, Wenting
   Zhao, Xiaochuan
   Wang, Lan
   Song, Mei
   Gao, Yuanyuan
   An, Cuixia
   Bashir, Shahid
   Wang, Xueyi
TI Effect of night shift work on metabolic syndrome in adults who suffered
   from earthquake stress in early life
SO FRONTIERS IN PUBLIC HEALTH
LA English
DT Article
DE pregnancy; infancy; earthquake stress; metabolic syndrome; night shift
   work; adulthood
ID PREVALENCE
AB ObjectiveTo examine the role of night shift work on the risk of metabolic syndrome (MetS) in adults suffered from earthquakes prenatally or as infants and to analyse the effect of stress on factors that influence MetS in this population. MethodsWe included 870 subjects from 2014 to 2015. All subjects work as miners for the Kailuan Mining Group and were born were living in Tangshan. Participants were classified into two groups on basis of their work schedules: day shift and night shift. They were further classified into the prenatal exposure group, the infancy exposure group, and the control group based on their age during the Tangshan earthquake. This study was conducted 38 years after the earthquake. Participants' general demographic data, smoking and drinking habits, as well as work schedules were collected. All participants' sleep status was assessed with the Pittsburgh Sleep Quality Index. The measurement of all subjects' waist circumference and blood pressure was made, and triglycerides, fasting blood glucose, high-density lipoproteins, and low-density lipoproteins were measured by collecting blood samples. The definition of MetS was made after the guidelines for preventing and controlling type 2 diabetes in China (2017 Edition). ResultsA total of 187 (21.5%) workers were determined to have MetS. The incidence of MetS was greatly higher in night shift workers who were exposed to an earthquake during infancy than in day shift workers (& chi;(2) = 8.053, p = 0.005). A multivariate logistic regression analysis displayed male participants had a higher risk develop MetS than female participants (p = 0.042, OR = 0.368, 95% CI = 0.140, 0.965). Current smokers (p = 0.030, OR = 1.520, 95%CI = 1.042, 2.218) and participants who sleep fewer than 7 h per night (p = 0.015, OR = 1.638, 95%CI = 1.101, 2.437) had a higher risk of MetS. Prenatal earthquake stress was also a risk element for MetS (p = 0.012, OR = 1.644, 95%CI = 1.115, 2.423). ConclusionThe risk of MetS is significantly higher in night shift workers exposed to earthquake stress during infancy than day shift workers. Earthquake exposure during pregnancy is an independent risk factor for MetS. Smoking and sleeping less than 7 h have a higher risk of MetS than the control group.
C1 [Li, Na; Wang, Ran; Hu, Peihua; Lu, Wenting; Zhao, Xiaochuan; Wang, Lan; Song, Mei; Gao, Yuanyuan; An, Cuixia; Wang, Xueyi] Hebei Med Univ, Hosp 1, Dept Psychiat, Shijiazhuang, Peoples R China.
   [Li, Na; Wang, Ran; Hu, Peihua; Lu, Wenting; Zhao, Xiaochuan; Wang, Lan; Song, Mei; Gao, Yuanyuan; An, Cuixia; Wang, Xueyi] Hebei Med Univ, Mental Hlth Ctr, Shijiazhuang, Peoples R China.
   [Li, Na; Wang, Ran; Hu, Peihua; Lu, Wenting; Zhao, Xiaochuan; Wang, Lan; Song, Mei; Gao, Yuanyuan; An, Cuixia; Wang, Xueyi] Clin Med Res Ctr Psychiat & Psychol Disorders Hebe, Shijiazhuang, Peoples R China.
   [Bashir, Shahid] King Fahad Specialist Hosp, Saudi Arabia Neurosci Ctr, Dammam, Saudi Arabia.
C3 Hebei Medical University; Hebei Medical University
RP Wang, XY (corresponding author), Hebei Med Univ, Hosp 1, Dept Psychiat, Shijiazhuang, Peoples R China.; Wang, XY (corresponding author), Hebei Med Univ, Mental Hlth Ctr, Shijiazhuang, Peoples R China.; Wang, XY (corresponding author), Clin Med Res Ctr Psychiat & Psychol Disorders Hebe, Shijiazhuang, Peoples R China.
EM ydyywxy@163.com
RI Bashir, Shahid/AFC-6566-2022; gao, yuanyuan/GSE-5627-2022; han,
   wei/ABG-2691-2021; Wang, Ran/GRX-9114-2022; Bashir, Shahid/HOA-8856-2023
OI Bashir, Shahid/0000-0001-6286-6895
FU Samp;T Program of Hebei [SG2021189]; Project of Clinical Medical
   Research Center for Psychiatric and Psychological Disorders of Hebei
   Province [199776245D]; Provincial Science and Technology Program of
   Hebei Province [21377711D]; Hebei Medical University Clinical Research
   Innovation Team [2022LCTD-A1]; Introduce Foreign Intellectual Projects
   of Finance Department in Hebei Province [YZ202204]; Medical Research
   Projects from Health Commission of Hebei Province [20210418]
FX This study was supported by the S & amp;T Program of Hebei (SG2021189),
   Project of Clinical Medical Research Center for Psychiatric and
   Psychological Disorders of Hebei Province (199776245D), Provincial
   Science and Technology Program of Hebei Province (21377711D), Hebei
   Medical University Clinical Research Innovation Team (2022LCTD-A1) and
   Introduce Foreign Intellectual Projects of Finance Department in Hebei
   Province (YZ202204). Medical Research Projects from Health Commission of
   Hebei Province (20210418).
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NR 41
TC 0
Z9 0
U1 1
U2 2
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 2296-2565
J9 FRONT PUBLIC HEALTH
JI Front. Public Health
PD JUL 20
PY 2023
VL 11
AR 1139113
DI 10.3389/fpubh.2023.1139113
PG 7
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA O1SO2
UT WOS:001041690000001
PM 37546325
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Liva, K
   Panagiotopoulos, AA
   Foscolou, A
   Amerikanou, C
   Vitali, A
   Zioulis, S
   Argyri, K
   Panoutsopoulos, GI
   Kaliora, AC
   Gioxari, A
AF Liva, Konstantina
   Panagiotopoulos, Athanasios A.
   Foscolou, Alexandra
   Amerikanou, Charalampia
   Vitali, Alkistis
   Zioulis, Stavros
   Argyri, Konstantina
   Panoutsopoulos, Georgios I.
   Kaliora, Andriana C.
   Gioxari, Aristea
TI High Polyphenol Extra Virgin Olive Oil and Metabolically Unhealthy
   Obesity: A Scoping Review of Preclinical Data and Clinical Trials
SO CLINICS AND PRACTICE
LA English
DT Review
DE extra virgin olive oil; polyphenols; obesity; metabolic syndrome;
   hydroxytyrosol; tyrosol; oxidative stress; inflammation
ID PHENOLIC-COMPOUNDS; LIPID PROFILE; GLOBAL BURDEN; OLEIC-ACID; RICH;
   SUPPLEMENTATION; CONSUMPTION; LIVER; DIET
AB Background/Objectives: During the last decade, there has been an increased interest in phenolic compound-rich natural products as natural therapies for regulating the molecular pathways behind central obesity and associated metabolic disorders. The present scoping review presents the outcomes of clinical and preclinical studies examining the anti-obesity effects of high phenolic extra virgin olive oil (HP-EVOO) and its possible underlying molecular mechanisms. Methods: Studies published between 2014 and 2024 were searched via MEDLINE, Scopus, Cochrane, the Web of Science, Semantic Scholar, Google Scholar, Science.gov, and Clinicaltrials.gov databases. A combination of keywords and Boolean logic was used to search throughout the last decade in all databases, including "hyperglycemia" or "hypertension" or "metabolic syndrome" or "dyslipidemia" or "hyperlipidemia" or "hypoglycemia" or "obesity" or "macrovascular diabetic complications" or "microvascular diabetic complications" or "cardiovascular disease" or "overweight" or "insulin sensitivity" or "insulin resistance" and "extra virgin olive oil" or "high phenolic olive oil" and "human" or "animal model". Results: The 10-year literature survey identified 21 studies in both animal models and humans, indicating that HP-EVOO improves inflammation, glycemic control, oxidative stress and endothelial function, potentially protecting against metabolic syndrome, hypertension and type 2 diabetes, even compared to EVOO. Moreover, HP-EVOO's antiplatelet effect and improvement in HDL functionality reduce cardiovascular risk. Conclusions: The evidence presented in this study demonstrates that HP-EVOO represents an effective preventive and therapeutic dietary approach to cardiometabolic diseases.
C1 [Liva, Konstantina; Panagiotopoulos, Athanasios A.; Foscolou, Alexandra; Vitali, Alkistis; Zioulis, Stavros; Argyri, Konstantina; Panoutsopoulos, Georgios I.; Gioxari, Aristea] Univ Peloponnese, Sch Hlth Sci, Dept Nutr Sci & Dietet, Antikalamos 24100, Kalamata, Greece.
   [Amerikanou, Charalampia; Kaliora, Andriana C.] Harokopio Univ, Sch Hlth Sci & Educ, Dept Dietet & Nutr Sci, 70 El Venizelou Ave, Athens 17676, Greece.
C3 Harokopio University Athens
RP Gioxari, A (corresponding author), Univ Peloponnese, Sch Hlth Sci, Dept Nutr Sci & Dietet, Antikalamos 24100, Kalamata, Greece.
EM k.liva@go.uop.gr; ath.panagiotopoulos@go.uop.gr;
   alexandra.foscolou@go.uop.gr; camer@hua.gr; kargyri@uop.gr;
   gpanouts@uop.gr; akaliora@hua.gr; a.gioxari@go.uop.gr
RI Panagiotopoulos, Athanasios/JBJ-6143-2023; Amerikanou,
   Charalampia/ABE-1634-2022; Kaliora, Andriana/AAM-2912-2021; Gioxari,
   Aristea/AAA-1163-2021
OI Panagiotopoulos, Athanasios A./0000-0002-8015-0484
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NR 59
TC 0
Z9 0
U1 2
U2 2
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
SN 2039-7275
EI 2039-7283
J9 CLINICS PRACT
JI Clin. Pract.
PD MAR 7
PY 2025
VL 15
IS 3
AR 54
DI 10.3390/clinpract15030054
PG 19
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA 0OE5T
UT WOS:001452037800001
PM 40136590
OA gold
DA 2025-06-11
ER

PT J
AU Ittichaicharoen, J
   Phrommintikul, A
   Chattipakorn, N
   Chattipakorn, S
AF Ittichaicharoen, Jitjiroj
   Phrommintikul, Arintaya
   Chattipakorn, Nipon
   Chattipakorn, Siriporn
TI Reduced salivary amylase activity in metabolic syndrome patients with
   obesity could be improved by treatment with a dipeptidyl peptidase IV
   inhibitor
SO CLINICAL ORAL INVESTIGATIONS
LA English
DT Article
DE Obesity; Metabolic syndrome; Salivary gland function; Amylase activity;
   Vildagliptin
ID DIABETES-MELLITUS; ALPHA-AMYLASE; MITOCHONDRIAL-FUNCTION; SYSTEMIC
   INFLAMMATION; OXIDATIVE STRESS; GLYCEMIC CONTROL; GLUCOSE;
   HYPERGLYCEMIA; GLYCATION; GLANDS
AB ObjectivesThe present study is to investigate the salivary gland function of metabolic syndrome (MetS) patients, as indicated by salivary flow rate, amylase activity, and salivary oxidative stress, by measuring MDA level.Materials and methodsOne hundred and eighty-one MetS patients from Maharaj Nakorn Chiang Mai Hospital were enrolled onto this study. The metabolic parameters of each patient were collected and evaluated. Unstimulated saliva was also collected for 5min. Salivary gland functions, including salivary flow rate, amylase activity, and salivary MDA levels, were investigated.ResultsHigh levels of triglycerides, high-density lipoprotein, blood pressure, and waist circumference in MetS patients did not show a correlation with altered salivary gland function. However, a decrease in salivary flow rate was observed in MetS patients with hyperglycemia. In addition, decreased amylase activity was found in MetS patients with obesity (BMI23kg/m(2)). Salivary amylase activity of MetS patients treated with dipeptidyl peptidase IV (DPP-IV) inhibitor was significantly greater than that observed in MetS patients without a DPP-IV inhibitor. Moreover, the salivary amylase activity in MetS patients was found to be independently positively correlated with DPP-IV inhibitor therapy (r=0.708, p<0.01).ConclusionThese findings suggest that obesity and hyperglycemia in MetS patients were associated with the impairment of salivary glands. Treatment with a DPP-IV inhibitor was found to exert beneficial effects on the salivary gland.Clinical relevanceThis study demonstrated the impairment of salivary glands of MetS patients and the beneficial effect of DPP-IV inhibitor treatment in the salivary glands.
C1 [Ittichaicharoen, Jitjiroj; Chattipakorn, Siriporn] Chiang Mai Univ, Fac Dent, Dept Oral Biol & Diagnost Sci, Chiang Mai 50200, Thailand.
   [Ittichaicharoen, Jitjiroj; Chattipakorn, Nipon; Chattipakorn, Siriporn] Chiang Mai Univ, Fac Med, Cardiac Electrophysiol Res & Training Ctr, Neurophysiol Unit, Chiang Mai 50200, Thailand.
   [Ittichaicharoen, Jitjiroj; Phrommintikul, Arintaya; Chattipakorn, Nipon; Chattipakorn, Siriporn] Chiang Mai Univ, Ctr Excellence Cardiac Electrophysiol Res, Chiang Mai 50200, Thailand.
   [Phrommintikul, Arintaya] Chiang Mai Univ, Fac Med, Dept Internal Med, Cardiol Unit, Chiang Mai 50200, Thailand.
   [Chattipakorn, Nipon] Chiang Mai Univ, Fac Med, Dept Physiol, Cardiac Electrophysiol Unit, Chiang Mai 50200, Thailand.
C3 Chiang Mai University; Chiang Mai University; Chiang Mai University;
   Chiang Mai University; Chiang Mai University
RP Chattipakorn, S (corresponding author), Chiang Mai Univ, Fac Dent, Dept Oral Biol & Diagnost Sci, Chiang Mai 50200, Thailand.; Chattipakorn, S (corresponding author), Chiang Mai Univ, Fac Med, Cardiac Electrophysiol Res & Training Ctr, Neurophysiol Unit, Chiang Mai 50200, Thailand.; Chattipakorn, S (corresponding author), Chiang Mai Univ, Ctr Excellence Cardiac Electrophysiol Res, Chiang Mai 50200, Thailand.
EM scchattipakorn@gmail.com
RI Phrommintikul, Arintaya/X-1881-2019; Chattipakorn, Nipon/AAJ-4049-2021
OI Chattipakorn, Siriporn/0000-0003-1677-7052; Phrommintikul,
   Arintaya/0000-0003-3986-1951
FU TRF-Senior Research Scholar [RTA6080003, RSA5780040]; Chiang Mai
   University [PHD/021/2556]; NSTDA Research Chair Grant from the National
   Science and Technology Development Agency Thailand; Chiang Mai
   University Center of Excellence Award; National Research Council of
   Thailand
FX TRF-Senior Research Scholar RTA6080003 (SC) and RSA5780040 (AP); the
   National Research Council of Thailand (SC); a CMU50th Anniversary grant
   by Chiang Mai University (PHD/021/2556 JI & a NSTDA Research Chair Grant
   from the National Science and Technology Development Agency Thailand
   (NC) and a Chiang Mai University Center of Excellence Award (NC).
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NR 53
TC 2
Z9 2
U1 0
U2 24
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1432-6981
EI 1436-3771
J9 CLIN ORAL INVEST
JI Clin. Oral Investig.
PD DEC
PY 2018
VL 22
IS 9
BP 3113
EP 3120
DI 10.1007/s00784-018-2402-5
PG 8
WC Dentistry, Oral Surgery & Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dentistry, Oral Surgery & Medicine
GA GZ5VC
UT WOS:000449496900018
PM 29520469
DA 2025-06-11
ER

PT J
AU Andres, AM
   Kooren, JA
   Parker, SJ
   Tucker, KC
   Ravindran, N
   Ito, BR
   Huang, CQ
   Venkatraman, V
   Van Eyk, JE
   Gottlieb, RA
   Mentzer, RM
AF Andres, Allen M.
   Kooren, Joel A.
   Parker, Sarah J.
   Tucker, Kyle C.
   Ravindran, Nandini
   Ito, Bruce R.
   Huang, Chengqun
   Venkatraman, Vidya
   Van Eyk, Jennifer E.
   Gottlieb, Roberta A.
   Mentzer, Robert M., Jr.
TI Discordant signaling and autophagy response to fasting in hearts of
   obese mice: Implications for ischemia tolerance
SO AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
LA English
DT Article
DE metabolic syndrome; peroxisome proliferator-activated
   receptor-alpha/gamma; mammalian target of rapamycin; proteomics
ID METABOLIC SYNDROME; CARDIOVASCULAR-DISEASE; MYOCARDIAL PROTECTION;
   INFARCT SIZE; REPERFUSION; ACTIVATION; SKYLINE; GLUCOSE; MTORC1; MS/MS
AB Autophagy is regulated by nutrient and energy status and plays an adaptive role during nutrient deprivation and ischemic stress. Metabolic syndrome (MetS) is a hypernutritive state characterized by obesity, dyslipidemia, elevated fasting blood glucose levels, and insulin resistance. It has also been associated with impaired autophagic flux and larger-sized infarcts. We hypothesized that dietinduced obesity (DIO) affects nutrient sensing, explaining the observed cardiac impaired autophagy. We subjected male friend virus B NIH (FVBN) mice to a high-fat diet, which resulted in increased weight gain, fat deposition, hyperglycemia, insulin resistance, and larger infarcts after myocardial ischemia-reperfusion. Autophagic flux was impaired after 4 wk on a high-fat diet. To interrogate nutrientsensing pathways, DIO mice were subjected to overnight fasting, and hearts were processed for biochemical and proteomic analysis. Obese mice failed to upregulate LC3-II or to clear p62/SQSTM1 after fasting, although mRNA for LC3B and p62/SQSTM1 were appropriately upregulated in both groups, demonstrating an intact transcriptional response to fasting. Energy-and nutrient-sensing signal transduction pathways[AMPK and mammalian target of rapamycin (mTOR)] also responded appropriately to fasting, although mTOR was more profoundly suppressed in obese mice. Proteomic quantitative analysis of the hearts under fed and fasted conditions revealed broad changes in protein networks involved in oxidative phosphorylation, autophagy, oxidative stress, protein homeostasis, and contractile machinery. In many instances, the fasting response was quite discordant between lean and DIO mice. Network analysis implicated the peroxisome proliferator-activated receptor and mTOR regulatory nodes. Hearts of obese mice exhibited impaired autophagy, altered proteome, and discordant response to nutrient deprivation.
C1 [Andres, Allen M.; Kooren, Joel A.; Parker, Sarah J.; Tucker, Kyle C.; Huang, Chengqun; Venkatraman, Vidya; Van Eyk, Jennifer E.; Gottlieb, Roberta A.; Mentzer, Robert M., Jr.] Cedars Sinai Heart Inst, 8700 Beverly Blvd, Los Angeles, CA 90048 USA.
   [Andres, Allen M.; Kooren, Joel A.; Parker, Sarah J.; Tucker, Kyle C.; Huang, Chengqun; Venkatraman, Vidya; Van Eyk, Jennifer E.; Gottlieb, Roberta A.; Mentzer, Robert M., Jr.] Dept Med, Los Angeles, CA USA.
   [Andres, Allen M.; Kooren, Joel A.; Parker, Sarah J.; Tucker, Kyle C.; Huang, Chengqun; Venkatraman, Vidya; Van Eyk, Jennifer E.; Gottlieb, Roberta A.; Mentzer, Robert M., Jr.] Cedars Sinai Med Ctr, Barbra Streisand Womens Heart Ctr, Los Angeles, CA 90048 USA.
   [Ravindran, Nandini; Ito, Bruce R.] San Diego State Univ, Donald P Shiley BioSci Ctr, San Diego, CA 92182 USA.
C3 Cedars Sinai Medical Center; Cedars Sinai Medical Center; California
   State University System; San Diego State University
RP Andres, AM (corresponding author), Cedars Sinai Heart Inst, 8700 Beverly Blvd, Los Angeles, CA 90048 USA.
EM Allen.Andres@cshs.org
OI Van Eyk, Jennifer/0000-0001-9050-148X
FU National Heart, Lung, and Blood Institute [P01-HL-112730]; American
   Heart Association SDG Grant [15SDG23230013]; American Heart Association
   (AHA) [15SDG23230013] Funding Source: American Heart Association (AHA)
FX This work was supported by National Heart, Lung, and Blood Institute
   Grant P01-HL-112730 (to R. A. Gottlieb) and American Heart Association
   SDG Grant 15SDG23230013 (to A. M. Andres).
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NR 48
TC 26
Z9 26
U1 0
U2 1
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0363-6135
EI 1522-1539
J9 AM J PHYSIOL-HEART C
JI Am. J. Physiol.-Heart Circul. Physiol.
PD JUL
PY 2016
VL 311
IS 1
BP H219
EP H228
DI 10.1152/ajpheart.00041.2016
PG 10
WC Cardiac & Cardiovascular Systems; Physiology; Peripheral Vascular
   Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Physiology
GA DY3CZ
UT WOS:000384969700023
PM 27199111
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Cordero-Herrera, I
   Kozyra, M
   Zhuge, ZB
   Haworth, SM
   Moretti, C
   Peleli, M
   Caldeira-Dias, M
   Jahandideh, A
   Han, HR
   Cruz, JD
   Kleschyov, AL
   Montenegro, MF
   Ingelman-Sundberg, M
   Weitzberg, E
   Lundberg, JO
   Carlstrom, M
AF Cordero-Herrera, Isabel
   Kozyra, Mikael
   Zhuge, Zhengbing
   Haworth, Sarah McCann
   Moretti, Chiara
   Peleli, Maria
   Caldeira-Dias, Mayara
   Jahandideh, Arghavan
   Han Huirong
   Cruz, Josiane de Campos
   Kleschyov, Andrei L.
   Montenegro, Marcelo F.
   Ingelman-Sundberg, Magnus
   Weitzberg, Eddie
   Lundberg, Jon O.
   Carlstrom, Mattias
TI AMP-activated protein kinase activation and NADPH oxidase inhibition by
   inorganic nitrate and nitrite prevent liver steatosis
SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF
   AMERICA
LA English
DT Article
DE nitrate; nitrite; nitric oxide; steatosis; microbiota
ID METABOLIC SYNDROME; XANTHINE OXIDOREDUCTASE; INSULIN-RESISTANCE;
   ABDOMINAL OBESITY; REDUCTION; ASSOCIATION; MODULATION; GENERATION;
   PATHWAY; RISK
AB Advanced age and unhealthy dietary habits contribute to the increasing incidence of obesity and type 2 diabetes. These metabolic disorders, which are often accompanied by oxidative stress and compromised nitric oxide (NO) signaling, increase the risk of adverse cardiovascular complications and development of fatty liver disease. Here, we investigated the therapeutic effects of dietary nitrate, which is found in high levels in green leafy vegetables, on liver steatosis associated with metabolic syndrome. Dietary nitrate fuels a nitrate-nitrite-NO signaling pathway, which prevented many features of metabolic syndrome and liver steatosis that developed in mice fed a high-fat diet, with or without combination with an inhibitor of NOS (L-NAME). These favorable effects of nitrate were absent in germ-free mice, demonstrating the central importance of host microbiota in bioactivation of nitrate. In a human liver cell line (HepG2) and in a validated hepatic 3D model with primary human hepatocyte spheroids, nitrite treatment reduced the degree of metabolically induced steatosis (i.e., high glucose, insulin, and free fatty acids), as well as drug-induced steatosis (i.e., amiodarone). Mechanistically, the salutary metabolic effects of nitrate and nitrite can be ascribed to nitrite-derived formation of NO species and activation of soluble guanylyl cyclase, where xanthine oxidoreductase is proposed to mediate the reduction of nitrite. Boosting this nitrate-nitrite-NO pathway results in attenuation of NADPH oxidase-derived oxidative stress and stimulation of AMP-activated protein kinase and downstream signaling pathways regulating lipogenesis, fatty acid oxidation, and glucose homeostasis. These findings may have implications for novel nutrition-based preventive and therapeutic strategies against liver steatosis associated with metabolic dysfunction.
C1 [Cordero-Herrera, Isabel; Kozyra, Mikael; Zhuge, Zhengbing; Haworth, Sarah McCann; Moretti, Chiara; Peleli, Maria; Caldeira-Dias, Mayara; Jahandideh, Arghavan; Han Huirong; Cruz, Josiane de Campos; Kleschyov, Andrei L.; Montenegro, Marcelo F.; Ingelman-Sundberg, Magnus; Weitzberg, Eddie; Lundberg, Jon O.; Carlstrom, Mattias] Karolinska Inst, Dept Physiol & Pharmacol, S-17177 Stockholm, Sweden.
   [Kleschyov, Andrei L.] Freiberg Instruments Ltd, Lab Biophys, D-09599 Freiberg, Germany.
   [Weitzberg, Eddie] Karolinska Univ Hosp, Dept Perioperat Med & Intens Care, S-17176 Stockholm, Sweden.
C3 Karolinska Institutet; Karolinska Institutet; Karolinska University
   Hospital
RP Lundberg, JO; Carlstrom, M (corresponding author), Karolinska Inst, Dept Physiol & Pharmacol, S-17177 Stockholm, Sweden.
EM jon.lundberg@ki.se; mattias.carlstrom@ki.se
RI Kleschyov, Andrei/AAQ-7749-2021; Cruz, Josiane/L-9780-2017; Han,
   Huirong/JXM-0776-2024; Peleli, Maria/AAQ-2326-2021; Montenegro,
   Marcelo/AAX-7172-2020; Ingelman-Sundberg, Magnus/ABD-9302-2021;
   Carlstrom, Mattias/E-7350-2015; zhuge, zhengbing/E-8210-2017
OI Carlstrom, Mattias/0000-0001-9923-8729; Freitas Montenegro,
   Marcelo/0000-0001-9137-8145; McCann Haworth, Sarah/0000-0002-4299-5486;
   Moretti, Chiara/0000-0002-0434-0278; Ingelman-Sundberg,
   Magnus/0000-0002-7255-9079; Lundberg, Jon/0000-0002-0174-5210;
   Kleshchev, Andrey/0000-0003-2300-1236; zhuge,
   zhengbing/0000-0002-6002-6670
FU Novo Nordisk postdoctoral fellowship; Swedish Research Council
   [2015-02760, 2016-01381]; Swedish Heart and Lung Foundation [20140448,
   20170124]; Novo-Nordisk [2-4078/2014]; European Research Council
   Advanced Grant (ERC-AdG) Project HEPASPHER Grant [742020]; Karolinska
   Institutet [2-3707/2013, 2-1930/2016]; Knut and Alice Wallenberg
   Foundation [KAW2008.0149];  [2-560/2015]
FX We thank Freiberg Instruments Ltd for the use of their EPR equipment
   (Magnettech MiniScope MS5000). We thank Glucox Biotech AB Stockholm for
   the kind gift of their NADPH oxidase inhibitors (GLX481304 and
   GLX7013114). We thank Carina Nihlen, Annika Olsson, Margareta
   Stensdotter, and Inger Johansson (Karolinska Institutet) for technical
   assistance. I.C.-H. is supported by a Novo Nordisk postdoctoral
   fellowship run in partnership with the Karolinska Institutet. This work
   was supported by Swedish Research Council Grants 2015-02760 and
   2016-01381, by Swedish Heart and Lung Foundation Grants 20140448 and
   20170124, by Novo-Nordisk Grant 2-4078/2014, by European Research
   Council Advanced Grant (ERC-AdG) Project HEPASPHER Grant Agreement
   742020, and by research funds (2-560/2015) and internal Karolinska
   Institutet funding for doctoral education (KID) (2-3707/2013 and
   2-1930/2016). M.K. was funded by an MD PhD program [Clinical Scientist
   Training Programme (CSTP)] grant from the Karolinska Institutet. The
   confocal microscope used was obtained by funding from the Knut and Alice
   Wallenberg Foundation (Grant KAW2008.0149).
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NR 45
TC 74
Z9 80
U1 1
U2 31
PU NATL ACAD SCIENCES
PI WASHINGTON
PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA
SN 0027-8424
EI 1091-6490
J9 P NATL ACAD SCI USA
JI Proc. Natl. Acad. Sci. U. S. A.
PD JAN 2
PY 2019
VL 116
IS 1
BP 217
EP 226
DI 10.1073/pnas.1809406115
PG 10
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA HG1IT
UT WOS:000454707700036
PM 30559212
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Zaki, M
   Basha, W
   El-Bassyouni, HT
   El-Toukhy, S
   Hussein, T
AF Zaki, Moushira
   Basha, Walaa
   El-Bassyouni, Hala T.
   El-Toukhy, Safinaz
   Hussein, Tamer
TI Evaluation of DNA damage profile in obese women and its association to
   risk of metabolic syndrome, polycystic ovary syndrome and recurrent
   preeclampsia
SO GENES & DISEASES
LA English
DT Article
DE DNA damage; Metabolic components; Obesity; PCOS; Recurrent preeclampsia
ID OXIDATIVE STRESS; INFLAMMATION; ANTIOXIDANTS; LYMPHOCYTES; HEALTH; PCOS
AB Metabolic syndrome (MS) is a cluster of metabolic abnormalities. Obesity and MS are always accompanied by elevated oxidative stress which might affect cellular bio-molecules such as DNA. The aim of the present study is to investigate DNA damage profile in obese premenopausal women and its relation to the risk of MS, polycystic ovary syndrome (PCOS) and history of recurrent pre-eclampsia. The study included 90 obese women included cases with MS (n = 30), PCOS (n = 30) and previous history of recurrent preeclampsia (n = 30) and, age-matched healthy non-obese control women (n = 50). The assessment of leukocyte DNA damage was done by comet assay for all cases and controls. Anthropometry and biochemical parameters have been measured. Results showed that mean percent of DNA damage was significantly higher in MS, PCOS as well as in women with the recurrent preeclampsia as compared to healthy controls. The high level of mean DNA damage frequency in obese women was significantly associated with the increased number of metabolic syndrome components. Cases with 2, 3 and 3-5 components showed significantly higher levels of DNA damage than controls. Moreover, cases with 3-5 MS components showed significant higher DNA compared to those with the two components. Regarding PCOS, significant positive association between the mean frequency of DNA damage and waist circumference was observed. The study suggests that metabolic abnormalities, PCOS and recurrent pre-eclampsia might be contributed in development of DNA damage in obese women. DNA damage can serve as an early marker for obesity complications in premenopausal women. Copyright (C) 2018, Chongqing Medical University.
C1 [Zaki, Moushira; Basha, Walaa] Natl Res Ctr, Med Res Div, Biol Anthropol Dept, Cairo, Egypt.
   [El-Bassyouni, Hala T.] Natl Res Ctr, Clin Genet Dept, Cairo, Egypt.
   [El-Toukhy, Safinaz] Natl Res Ctr, Med Res Div, Med Biochem Dept, Cairo, Egypt.
   [Hussein, Tamer] Natl Res Ctr, Med Res Div, Reprod Hlth Res Dept, Cairo, Egypt.
C3 Egyptian Knowledge Bank (EKB); National Research Centre (NRC); Egyptian
   Knowledge Bank (EKB); National Research Centre (NRC); Egyptian Knowledge
   Bank (EKB); National Research Centre (NRC); Egyptian Knowledge Bank
   (EKB); National Research Centre (NRC)
RP Zaki, M (corresponding author), Natl Res Ctr, Med Res Div, Biol Anthropol Dept, Cairo, Egypt.
EM moushiraz@yahoo.com
RI eltoukhy, safinaz/M-1245-2019; El-Bassyouni, Hala/A-1955-2016; Basha,
   Walaa/B-4365-2016
OI El-Bassyouni, Hala/0000-0001-9825-1219; Basha,
   Walaa/0000-0002-4159-8139; Taha, Tamer/0000-0002-7091-3441
FU National Research Center, Egypt
FX Authors acknowledge the financial assistance provided by National
   Research Center, Egypt.
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NR 39
TC 23
Z9 26
U1 1
U2 7
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2352-4820
EI 2352-3042
J9 GENES DIS
JI Genes Dis.
PD DEC
PY 2018
VL 5
IS 4
BP 367
EP 373
DI 10.1016/j.gendis.2018.03.001
PG 7
WC Biochemistry & Molecular Biology; Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Genetics & Heredity
GA HE1SJ
UT WOS:000453053300011
PM 30591939
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Koziróg, M
   Poliwczak, AR
   Duchnowicz, P
   Koter-Michalak, M
   Sikora, J
   Broncel, M
AF Kozirog, Marzena
   Poliwczak, Adam Rafal
   Duchnowicz, Piotr
   Koter-Michalak, Maria
   Sikora, Joanna
   Broncel, Marlena
TI Melatonin treatment improves blood pressure, lipid profile, and
   parameters of oxidative stress in patients with metabolic syndrome
SO JOURNAL OF PINEAL RESEARCH
LA English
DT Article
DE blood pressure; melatonin; metabolic syndrome; oxidative stress
ID ESSENTIAL-HYPERTENSION; RATS; CHOLESTEROL; AUTOXIDATION; DAMAGE; WOMEN;
   DIET
AB Experimental studies have proven that melatonin has many beneficial pleiotropic actions. The aim of this study was to assess melatonin efficacy in patients with metabolic syndrome (MS). The study included 33 healthy volunteers (who were not treated with melatonin) and 30 patients with MS, who did not respond to 3-month lifestyle modification. Patients with MS were treated with melatonin (5 mg/day, 2 hr before bedtime) for 2 months. The following parameters were studied: systolic and diastolic blood pressure (SBP, DBP), levels of glucose, serum lipids, C-reactive protein, fibrinogen, activities of antioxidative enzymes: catalase (CAT), glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), thiobarbituric acid reactive substrates (TBARS). After 2-month therapy in comparison with baseline, the following significant changes were measured: systolic blood pressure (132.8 +/- 9.8 versus 120.5 +/- 11.0 mmHg, P < 0.001), DBP (81.7 +/- 8.8 versus 75 +/- 7.4 mmHg, P < 0.01), low-density lipoprotein cholesterol (LDL-C) (149.7 +/- 26.4 versus 139.9 +/- 30.2 mg/dL, P < 0.05), TBARS (0.5 +/- 0.2 versus 0.4 +/- 0.1 mu m/gHb, P < 0.01), and CAT (245.9 +/- 46.9 versus 276.8 +/- 39.4 U/gHb). Melatonin administered for 2 months significantly improved antioxidative defense (increase in CAT activity, decrease in TBARS level) and lipid profile (decrease in LDL-C), and lowered blood pressure. We conclude that melatonin therapy may be of benefit for patients with MS, particularly with arterial hypertension. Further studies with higher doses of melatonin or prolonged supplementation are awaited.
C1 [Kozirog, Marzena; Poliwczak, Adam Rafal; Broncel, Marlena] Med Univ Lodz, Dept Internal Dis & Clin Pharmacol, PL-91347 Lodz, Poland.
   [Duchnowicz, Piotr; Koter-Michalak, Maria] Univ Lodz, Dept Environm Pollut Biophys, PL-90131 Lodz, Poland.
   [Sikora, Joanna] Med Univ Lodz, Dept Pharmaceut Chem & Drug Anal, PL-91347 Lodz, Poland.
C3 Medical University Lodz; University of Lodz; Medical University Lodz
RP Broncel, M (corresponding author), Med Univ Lodz, Dept Internal Dis & Clin Pharmacol, Kniaziewicza St 1-5, PL-91347 Lodz, Poland.
EM marlena.broncel@umed.lodz.pl
RI Sikora, Joanna/J-5197-2012; Poliwczak, Adam/AAT-6218-2020; Duchnowicz,
   Piotr/F-2162-2018
OI Duchnowicz, Piotr/0000-0002-3514-9716; Sikora,
   Joanna/0000-0001-7044-9696; Broncel, Marlena/0000-0003-3659-8115;
   Poliwczak, Adam/0000-0002-5281-0318; Koter-Michalak,
   Maria/0000-0001-8660-4136
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NR 44
TC 223
Z9 229
U1 2
U2 17
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0742-3098
EI 1600-079X
J9 J PINEAL RES
JI J. Pineal Res.
PD APR
PY 2011
VL 50
IS 3
BP 261
EP 266
DI 10.1111/j.1600-079X.2010.00835.x
PG 6
WC Endocrinology & Metabolism; Neurosciences; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Physiology
GA 733KW
UT WOS:000288262600004
PM 21138476
DA 2025-06-11
ER

PT J
AU Leber, B
   Tripolt, NJ
   Blattl, D
   Eder, M
   Wascher, TC
   Pieber, TR
   Stauber, R
   Sourij, H
   Oettl, K
   Stadlbauer, V
AF Leber, B.
   Tripolt, N. J.
   Blattl, D.
   Eder, M.
   Wascher, T. C.
   Pieber, T. R.
   Stauber, R.
   Sourij, H.
   Oettl, K.
   Stadlbauer, V.
TI The influence of probiotic supplementation on gut permeability in
   patients with metabolic syndrome: an open label, randomized pilot study
SO EUROPEAN JOURNAL OF CLINICAL NUTRITION
LA English
DT Article
DE endotoxin; gut permeability; metabolic syndrome; Lactobacillus casei
   Shirota
ID DIET-INDUCED OBESITY; POLYMORPHONUCLEAR LEUKOCYTES CONSTITUTE; OXIDATIVE
   STRESS; INTESTINAL PERMEABILITY; INSULIN-RESISTANCE; POSSIBLE LINK;
   HUMAN SERUM; INFLAMMATION; ENDOTOXEMIA; MICROBIOTA
AB BACKGROUND/OBJECTIVES: Obesity and metabolic disorders are linked to inflammation via gut microbiota and/or gut permeability. Gut-derived endotoxin triggers inflammation leading to metabolic syndrome (MetS) and contributing to oxidative stress. We intended to investigate the effect of Lactobacillus casei Shirota on gut permeability, presence of endotoxin and neutrophil function in MetS.
   SUBJECTS/METHODS: Patients with MetS were randomized to receive 3 x 6.5 x 10(9) CFU L. casei Shirota (probiotic group) or not for 3 months. Gut permeability was assessed by a differential sugar absorption method and by determination of diaminooxidase serum levels, endotoxin by an adapted limulus amoebocyte lysate assay, neutrophil function and toll-like receptor (TLR) expression by flow cytometry and ELISA was used to detect lipopolysaccharide-binding protein (LBP) and soluble CD14 (sCD14) levels.
   RESULTS: Twenty-eight patients and 10 healthy controls were included. Gut permeability was significantly increased in MetS compared with controls but did not differ between patient groups. None of the patients were positive for endotoxin. LBP and sCD14 levels were not significantly different from healthy controls. High-sensitive C-reactive protein and LBP levels slightly but significantly increased after 3 months within the probiotics group. Neutrophil function and TLR expression did not differ from healthy controls or within the patient groups.
   CONCLUSIONS: Gut permeability of MetS patients was increased significantly compared with healthy controls. L. casei Shirota administration in the MetS patients did not have any influence on any parameter tested possibly due to too-short study duration or underdosing of L. casei Shirota.
C1 [Tripolt, N. J.; Eder, M.; Sourij, H.] Med Univ Graz, Cardiovasc Diabetol Res Grp, Div Endocrinol & Metab, Dept Internal Med, A-8010 Graz, Austria.
   [Leber, B.; Blattl, D.] Med Univ Graz, Dept Surg, Div Transplantat Surg, A-8010 Graz, Austria.
   [Wascher, T. C.] Hanusch Hosp, Dept Med 1, Vienna, Austria.
   [Stauber, R.; Stadlbauer, V.] Med Univ Graz, Div Gastroenterol & Hepatol, Dept Internal Med, A-8010 Graz, Austria.
   [Oettl, K.] Med Univ Graz, Inst Physiol Chem, A-8010 Graz, Austria.
C3 Medical University of Graz; Medical University of Graz; WGKK - Hanusch
   Hospital; Medical University of Graz; Medical University of Graz
RP Sourij, H (corresponding author), Med Univ Graz, Cardiovasc Diabetol Res Grp, Div Endocrinol & Metab, Dept Internal Med, Auenbruggerpl 15, A-8010 Graz, Austria.
EM ha.sourij@medunigraz.at
RI Tripolt, Norbert/AFP-4429-2022; Sourij, Harald/V-3370-2019
OI Tripolt, Norbert/0000-0002-7566-2047; Stadlbauer,
   Vanessa/0000-0001-5508-8271; Oettl, Karl/0000-0001-9792-5760; Sourij,
   Harald/0000-0003-3510-9594; Pieber, Thomas/0000-0003-3554-0405
FU Yakult Europe; Oesterreichische Nationalbank [12930, 13699]; Austrian
   Science Fund [P24362]; Styrian Government [A3-16.M-1/2011-25]
FX This work was supported in part by Yakult Europe. BL, ME and NJT are
   supported by funds of the Oesterreichische Nationalbank (Anniversary
   Fund, project numbers: 12930 to VS and 13699 to HS), the Austrian
   Science Fund (project P24362 to VS) and the Styrian Government (project
   A3-16.M-1/2011-25 to HS). We thank the team of the 'Centre for medical
   Research' (ZMF) of the Medical University of Graz for technical support.
CR Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
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NR 30
TC 88
Z9 104
U1 0
U2 33
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0954-3007
EI 1476-5640
J9 EUR J CLIN NUTR
JI Eur. J. Clin. Nutr.
PD OCT
PY 2012
VL 66
IS 10
BP 1110
EP 1115
DI 10.1038/ejcn.2012.103
PG 6
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 018FS
UT WOS:000309646100007
PM 22872030
OA Bronze
DA 2025-06-11
ER

PT J
AU López-Uriarte, P
   Nogués, R
   Saez, G
   Bulló, M
   Romeu, M
   Masana, L
   Tormos, C
   Casas-Agustench, P
   Salas-Salvadó, J
AF Lopez-Uriarte, Patricia
   Nogues, Rosa
   Saez, Guillermo
   Bullo, Monica
   Romeu, Marta
   Masana, Lluis
   Tormos, Carmen
   Casas-Agustench, Patricia
   Salas-Salvado, Jordi
TI Effect of nut consumption on oxidative stress and the endothelial
   function in metabolic syndrome
SO CLINICAL NUTRITION
LA English
DT Article
DE Nuts; Antioxidant capacity; Lipid oxidation; DNA damage; Endothelial
   function; Metabolic syndrome
ID LOW-DENSITY-LIPOPROTEIN; RANDOMIZED CROSSOVER TRIAL; ABSORBENCY CAPACITY
   ASSAY; ENRICHED DIET INCREASES; CORONARY-HEART-DISEASE; DNA-DAMAGE;
   IN-VITRO; HYPERCHOLESTEROLEMIC SUBJECTS; CARDIOVASCULAR-DISEASE; ALMOND
   CONSUMPTION
AB Background & aims: Oxidative stress has a key role in atherosclerosis, cancer and other chronic diseases. Some bioactive compounds in nuts have been implicated in antioxidant activities. Objective: We assessed how nut consumption affected several markers of oxidation and endothelial function (EF) in metabolic syndrome (MetS) patients.
   Patients and methods: A randomized, controlled, parallel feeding trial was conducted on 50 MetS adults who were recommended a healthy diet supplemented or not with 30 g of mixed nuts (Nut and Control groups, respectively) every day for 12 weeks. The plasma antioxidant capacity (AC), oxidized LDL (oxLDL), conjugated diene (CD) formation, urine 8-isoprostanes, DNA damage assessed by yield of urine 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxo-dG), and EF assessed by peripheral artery tonometry (PAT) and biochemical markers, were measured at baseline and the end of the intervention.
   Results: No significant differences in changes between groups were observed in AC, oxLM, CD, 8-isoprostanes or EF during the intervention, whereas the reduction in DNA damage was significant in the Nut group compared to Control group (P < 0.001).
   Conclusion: Nut consumption has no deleterious effect on lipid oxidation. The decrease in DNA damage observed in this study could contribute to explain the beneficial effects of regular nut consumption on some MetS features and several chronic diseases. (c) 2009 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.
C1 [Lopez-Uriarte, Patricia; Bullo, Monica; Casas-Agustench, Patricia; Salas-Salvado, Jordi] Univ Rovira & Virgili, Hosp Univ St Joan de Reus, Fac Med & Hlth Sci, Human Nutr Unit,IISPV, Tarragona 43201, Spain.
   [Nogues, Rosa; Romeu, Marta] Univ Rovira & Virgili, Fac Med & Hlth Sci, Pharmacol Unit, E-43201 Reus, Spain.
   [Saez, Guillermo; Tormos, Carmen] Univ Valencia, Med Sch Valencia, Dept Biochem & Mol Biol, Valencia, Spain.
   [Bullo, Monica; Salas-Salvado, Jordi] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr 06 03, Madrid, Spain.
   [Masana, Lluis] Univ Rovira & Virgili, Hosp Univ St Joan de Reus, Fac Med & Hlth Sci, Unit Lipids & Atherosclerosis,IISPV, E-43201 Reus, Spain.
   [Masana, Lluis] CIBERDEM Diabet & Associated Metab Dis, Barcelona, Spain.
C3 Universitat Rovira i Virgili; Institut d'Investigacio Sanitaria Pere
   Virgili (IISPV); Universitat Rovira i Virgili; University of Valencia;
   Instituto de Salud Carlos III; Universitat Rovira i Virgili; Institut
   d'Investigacio Sanitaria Pere Virgili (IISPV); CIBER - Centro de
   Investigacion Biomedica en Red; CIBERDEM
RP Salas-Salvadó, J (corresponding author), Univ Rovira & Virgili, Hosp Univ St Joan de Reus, Fac Med & Hlth Sci, Human Nutr Unit,IISPV, St Llorenc 21, Tarragona 43201, Spain.
EM jordi.salas@urv.cat
RI ROMEU, MARTA/O-7129-2019; MASANA, LUIS/M-7002-2019; Casas,
   Patricia/KBC-3404-2024; Lopez-Uriarte, Patricia/J-2527-2016; Bullo,
   Monica/F-2925-2016; , Patricia Casas-Agustench/M-7762-2014; ROMEU,
   MARTA/A-8468-2014; Salas-Salvado, Jordi/C-7229-2017; Lopez Uriarte,
   Patricia Josefina/D-5481-2011
OI Bullo, Monica/0000-0002-0218-7046; , Patricia
   Casas-Agustench/0000-0003-4424-1087; ROMEU, MARTA/0000-0002-2131-1858;
   Salas-Salvado, Jordi/0000-0003-2700-7459; Saez,
   Guillermo/0000-0002-8164-4048; Lopez Uriarte, Patricia
   Josefina/0000-0002-8459-5368; Masana, Luis/0000-0002-0789-4954
FU International Nut Council, Reus, Spain; Spanish Ministry of Education
   and Science [CICYT-AGL2005-0365]; Spanish Ministry of Health [RTIC
   RD06/0045]; International Nut Council; Generalitat de Catalunya's
   Department of Universities; Research and the Information Society;
   European Social Funds
FX J. Salas-Salvado has received research funding from the International
   Nut Council, Reus, Spain. He is a nonpaid member of the Scientific
   Advisory Board of the International Nut Council. Monica Bullo, Patricia
   Casas-Agustench, Patricia Lopez-Uriarte, Lluis Masana, Rosa Nogues,
   Marta Romeu, Guillermo Saez and Carmen Tormos, no conflict of interest.
   This study was supported by the Spanish Ministry of Education and
   Science (CICYT-AGL2005-0365), Spanish Ministry of Health (RTIC
   RD06/0045), and the International Nut Council. Borges S.A. (Reus, Spain)
   donated the walnuts used in this study. CIBER Fisiopatologia de la
   Obesidad y Nutricion (CIBEROBN) is an initiative of ISCIII. Patricia
   Lopez-Uriarte is the recipient of a predoctoral fellowship from the
   Generalitat de Catalunya's Department of Universities, Research and the
   Information Society and the European Social Funds. We thank Adriana
   Gomez-Flores for her collaboration in the acquisition of the nutritional
   data.
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NR 50
TC 87
Z9 99
U1 1
U2 28
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0261-5614
EI 1532-1983
J9 CLIN NUTR
JI Clin. Nutr.
PD JUN
PY 2010
VL 29
IS 3
BP 373
EP 380
DI 10.1016/j.clnu.2009.12.008
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 619EX
UT WOS:000279413100016
PM 20064680
DA 2025-06-11
ER

PT J
AU Arredondo, M
   Fuentes, M
   Jorquera, D
   Candia, V
   Carrasco, E
   Leiva, E
   Mujica, V
   Hertrampf, E
   Pérez, F
AF Arredondo, Miguel
   Fuentes, Marcela
   Jorquera, Denisse
   Candia, Valeria
   Carrasco, Elena
   Leiva, Elba
   Mujica, Veronica
   Hertrampf, Eva
   Perez, Francisco
TI Cross-Talk Between Body Iron Stores and Diabetes: Iron Stores are
   Associated with Activity and Microsatellite Polymorphism of the Heme
   Oxygenase and Type 2 Diabetes
SO BIOLOGICAL TRACE ELEMENT RESEARCH
LA English
DT Article
DE Type 2 diabetes mellitus; Metabolic syndrome; Iron; Heme oxygenase;
   Microsatellite polymorphism
ID GENE PROMOTER; METABOLIC SYNDROME; SERUM FERRITIN; SUSCEPTIBILITY; RISK;
   EXPRESSION; DNA
AB To assess the relationship between the length of (GT) (n) repeats in HO-1 gene promoter and heme oxygenase (HO) enzymatic activity in mononuclear cells with iron (Fe) stores in type 2 diabetic mellitus (DM2) patients and metabolic syndrome (MS) subjects, we studied 163 patients with DM2, 185 with MS, and 120 controls subjects. We evaluated iron status (hemoglobin and serum Fe, ferritin, and transferrin receptor), and we determined the length of (GT) (n) repeats in HO-1 gene promoter by capillary electrophoresis and HO enzymatic activity in mononuclear cells and assessed the relationship between these results and Fe stores. Only 1/163, 6/185, and 7/120 had iron deficiency anemia in DM2 patients, MS subjects, and controls, respectively. No iron overload (ferritin > 200 mu g/L) was detected in all the subjects studied. DM2 patients had higher iron deposits, total body iron, and heme oxygenase activity (a suggestion of high oxidative stress condition) than MS subjects and controls. In DM2, we found a positive association between serum iron and HO activity. There were no difference in allelic frequency between the three groups; however, among DM2 and MS patients, the frequency of short/medium (SM) genotype of (GT) (n) repetition was increased and medium/medium (MM) genotype of (GT) (n) repetition was lower than controls. These results imply that DM2 patients and individuals with MS carrying SM repeats might have higher susceptibility to develop diabetes consequences. This increased susceptibility could be Fe-mediated oxidative stress.
C1 [Arredondo, Miguel; Fuentes, Marcela; Jorquera, Denisse; Candia, Valeria; Hertrampf, Eva] Univ Chile, Micronutrient Lab, Nutr Inst & Food Technol INTA, Santiago, Chile.
   [Carrasco, Elena] Univ Chile, Fac Med, Dept Med, Diabet Unit, Santiago, Chile.
   [Leiva, Elba; Mujica, Veronica] Univ Talca, Dept Clin Biochem & Immunohematol, Fac Hlth Sci, Talca, Chile.
   [Perez, Francisco] Univ Chile, Fac Med, Dept Nutr, Santiago, Chile.
C3 Universidad de Chile; Universidad de Chile; Universidad de Talca;
   Universidad de Chile
RP Arredondo, M (corresponding author), Univ Chile, Micronutrient Lab, Nutr Inst & Food Technol INTA, El Libano 5524, Santiago, Chile.
EM marredon@inta.cl
RI Perez Rodríguez, Francisco/GRN-8495-2022; Jorquera,
   Denisse/JNR-2853-2023
OI Mujica, Veronica/0000-0001-6290-410X; Jorquera,
   Denisse/0000-0002-8907-6022
FU Fondo Nacional de Ciencia y Tecnologia (FONDECYT), Chile [1051006,
   1085173]
FX This work was supported by Fondo Nacional de Ciencia y Tecnologia
   (FONDECYT) grant # 1051006 and 1085173, Chile.
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NR 25
TC 20
Z9 20
U1 0
U2 8
PU HUMANA PRESS INC
PI TOTOWA
PA 999 RIVERVIEW DRIVE SUITE 208, TOTOWA, NJ 07512 USA
SN 0163-4984
EI 1559-0720
J9 BIOL TRACE ELEM RES
JI Biol. Trace Elem. Res.
PD NOV
PY 2011
VL 143
IS 2
BP 625
EP 636
DI 10.1007/s12011-010-8895-7
PG 12
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 829UH
UT WOS:000295609300004
PM 21080099
DA 2025-06-11
ER

PT J
AU Demirbag, R
   Yilmaz, R
   Gur, M
   Celik, H
   Guzel, S
   Selek, S
   Kocyigit, A
AF Demirbag, R.
   Yilmaz, R.
   Gur, M.
   Celik, H.
   Guzel, S.
   Selek, S.
   Kocyigit, A.
TI DNA damage in metabolic syndrome and its association with antioxidative
   and oxidative measurements
SO INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
LA English
DT Article
DE metabolic syndrome; DNA damage; total antioxidant capacity
ID INSULIN-RESISTANCE; STRESS; SEVERITY; GLUCOSE; MARKERS; DISEASE; PLASMA;
   AGE
AB The purpose of this study was to assess DNA damage levels in subjects with metabolic syndrome (MetS). Sixty-five subjects with MetS and 65 controls were enrolled in this study. Levels of DNA damage, total antioxidant capacity (TAC), total peroxide and oxidative stress index (OSI) were measured. We found that DNA damage levels were significantly increased [155.5 (60-264) vs. 93.2 (0-208) arbitrary units; p < 0.001] and TAC levels were significantly decreased in MetS than in control (1.34 +/- 0.27 vs. 55 +/- 0.33 mmol Trolox equivalent/l; p < 0.001). A significant falling trend in TAC levels and a significant rising trend in DNA damage values with the increase in the number of metabolic disturbances (ANOVA p < 0.001 for both) were observed. Total peroxide (30.9 +/- 4.9 vs. 21.3 +/- 2.5 mu mol H2O2/l; p < 0.001) and OSI levels [2.4 (1.3-3.8) vs. 1.4 (0.7-2.3) arbitrary units; p < 0.001] were significantly higher in the subjects with MetS than in controls. We found significant negative correlation between DNA damage and TAC levels in MetS (r = -0.656, p < 0.001) and in control (r = -0.546, p < 0.001). In multiple linear regression analysis, age, body mass index, presence of MetS and number of the componens of MetS were independent predictors of log-transformed DNA damage (p < 0.05, for all). DNA damage is increased in patients with MetS. The increase in DNA damage might be occur because of the increase in the imbalance between the production of oxidants and antioxidant defences in subjects with MetS.
C1 Harran Univ, Fac Med, Dept Cardiol, Sanliurfa, Turkey.
   Harran Univ, Fac Med, Dept Clin Biochem, Sanliurfa, Turkey.
C3 Harran University; Harran University
RP Demirbag, R (corresponding author), PK 112, Sanliurfa, Turkey.
EM rdemirbag@yahoo.com
RI Kocyigit, Abdurrahim/P-8685-2019; ÇELİK, HACİ/AAL-5433-2020; Demirbag,
   Recep/Z-2369-2019; SELEK, Sahabettin/N-9323-2019
OI Demirbag, Recep/0000-0001-7831-2715; SELEK,
   Sahabettin/0000-0003-1235-3957
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NR 31
TC 59
Z9 64
U1 0
U2 9
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1368-5031
EI 1742-1241
J9 INT J CLIN PRACT
JI Int. J. Clin. Pract.
PD OCT
PY 2006
VL 60
IS 10
BP 1187
EP 1193
DI 10.1111/j.1742-1241.2006.01042.x
PG 7
WC Medicine, General & Internal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Pharmacology & Pharmacy
GA 082RG
UT WOS:000240404300011
PM 16981963
DA 2025-06-11
ER

PT J
AU Efthymiou, D
   Zekakos, DX
   Papatriantafyllou, E
   Ziagkas, E
   Petrelis, AN
   Vassilopoulou, E
AF Efthymiou, Dimitris
   Zekakos, Dimitrios X.
   Papatriantafyllou, Evangelia
   Ziagkas, Efthimis
   Petrelis, Alexandros N.
   Vassilopoulou, Emilia
TI Gait Alterations in the Prediction of Metabolic Syndrome in Patients
   With Schizophrenia: A Pilot Study With PODOSmart ® Insoles
SO FRONTIERS IN PSYCHIATRY
LA English
DT Article
DE antipsychotics; metabolic syndrome; gait analysis; inflammation;
   gaitline; speed; weight; PODOSmart (R)
ID C-REACTIVE PROTEIN; WEIGHT-GAIN; ANTIPSYCHOTICS; DISORDERS; ANKLE;
   DISTURBANCES; OUTPATIENTS; MECHANISMS; PSYCHOSIS; CHILDREN
AB Background:& nbsp;Second-generation antipsychotics (APs) are associated with metabolic syndrome (MetS), characterized by abnormal pro-inflammatory cytokine production and oxidative stress due to the reduced antioxidant systems, and neurological effects, including mobility impairment. This pilot study investigated relationships between inflammatory-metabolic biomarkers, MetS and gait alterations in patients with psychosis treated with APs.& nbsp;Methods:& nbsp;Patients with psychosis treated with APs, 20 with MetS (MPS group) and 20 without MetS (PS group) were studied, usinganthropometric data, blood measurements and gait analysis performed with the PODOSmart (R) gait analysis device.& nbsp;Results and Discussion:& nbsp;The MPS group had significantly higher mean body mass index (BMI) and arterial blood pressure (BP) than the PS group. PODOSmart (R) gait analysis recorded significant differences between groups in pronation-supination at Heel Off (HO), gaitline HO and gaitline Toe Off (TO). Multifactorial elastic net regression models demonstrated significant association with MetS of inflammatory markers, specific AP2 treatment, gender, age; BMI; BP and smoking (accuracy lambda = 0.08), and in relation to gait parameters (accuracy lambda = 0.750), the three pronation- supination variables, i.e., at HO, flat foot in (AP2 related) and TO, and propulsion speed. The gait parameters were at the edges of the model, thus indicating a more significant role of these parameters compared to the other clinical variables. Early diagnosis of MetS in patients with schizophrenia via identification of gait alterations can be a screening measure for serious cardiovascular complications related to psychosis and APs, to enable timely dietary intervention that can control the pro-inflammatory state and reduce oxidative stress.
C1 [Efthymiou, Dimitris] Aristotle Univ Thessaloniki, Sch Med, Dept Psychiat, Div Neurosci, Thessaloniki, Greece.
   [Zekakos, Dimitrios X.; Petrelis, Alexandros N.] Digitsole SAS, Nancy, France.
   [Papatriantafyllou, Evangelia; Vassilopoulou, Emilia] Int Hellen Univ, Dept Nutr Sci & Dietet, Thessaloniki, Greece.
   [Ziagkas, Efthimis] Aristotle Univ Thessaloniki, Lab Motor Behav, Thessaloniki, Greece.
C3 Aristotle University of Thessaloniki; International Hellenic University;
   Aristotle University of Thessaloniki
RP Vassilopoulou, E (corresponding author), Int Hellen Univ, Dept Nutr Sci & Dietet, Thessaloniki, Greece.
EM vassilopoulouemilia@gmail.com
RI ; Vassilopoulou, Emilia/AAE-7270-2021
OI Petrelis, Alexandros/0000-0001-9156-4896; Vassilopoulou,
   Emilia/0000-0002-2665-5908
FU Digitsole SAS, Nancy, France
FX This research was funded by Digitsole SAS, Nancy, France.
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NR 59
TC 4
Z9 4
U1 0
U2 5
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-0640
J9 FRONT PSYCHIATRY
JI Front. Psychiatry
PD JAN 27
PY 2022
VL 13
AR 756600
DI 10.3389/fpsyt.2022.756600
PG 10
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA YW9GZ
UT WOS:000753720700001
PM 35153872
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Pourgholi, L
   Pourgholi, F
   Ziaee, S
   Goodarzynejad, H
   Hosseindokht, M
   Boroumand, M
   Mandegary, A
AF Pourgholi, Leyla
   Pourgholi, Fatemeh
   Ziaee, Shayan
   Goodarzynejad, Hamidreza
   Hosseindokht, Maryam
   Boroumand, Mohammadali
   Mandegary, Ali
TI The association between CYBA gene C242T variant and risk of
   metabolic syndrome
SO EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
LA English
DT Article
DE C242T polymorphism; CYBA gene; metabolic syndrome; NADPH oxidase;
   phoxp22; ROS
ID P22 PHOX GENE; OXIDATIVE STRESS; NAD(P)H OXIDASE; POLYMORPHISM;
   PREVALENCE; P22(PHOX); DISEASE; POPULATION
AB Background Both inflammation and oxidative stress may contribute to pathogenesis of metabolic syndrome (MetS). The C242T polymorphism (rs4673) in the CYBA gene, as the main components of NAD (P) H oxidase, causes inter-individual variability in the enzyme activity. We aimed to investigate the association between this polymorphism with MetS and its components. Methods Two hundred nine patients with MetS and 232 controls were included in this study. MetS was defined based on NCEP ATP-III A criteria with some modifications. The C242T polymorphism within CYBA gene was determined by using PCR-based restriction fragment length polymorphism (PCR-RFLP) method. Results After applying a multiple logistic regression model with adjusting for potential confounders of MetS including, age, sex, body mass index, hypertension, used medications, and diabetes mellitus, C242T polymorphism was found to be associated with the presence of MetS in men but not in the total population or in women. T allele as compared to C allele was associated with decreased odds of MetS in men (adjusted OR = 0.42, 95% CI = 0.24-0.74;P = .003), but not in women (adjusted OR = 1.03, 95% CI = 0.07-1.61;P = .890), or in the total population (adjusted OR = 0.72, 95% CI = 0.51-1.02;P = .063). Conclusion This study shows that T allele of C242T polymorphism in CYBA gene is protective against MetS in Iranian men but not in women. Further cohort studies with larger sample size in subgroups of men and women are required to confirm such association in other racial or ethnic group.
C1 [Pourgholi, Leyla; Ziaee, Shayan; Hosseindokht, Maryam; Boroumand, Mohammadali] Univ Tehran Med Sci, Tehran Heart Ctr, Dept Pathol & Lab Med, Tehran, Iran.
   [Pourgholi, Leyla; Mandegary, Ali] Kerman Univ Med Sci, Sch Pharm, Dept Pharmacol & Toxicol, POB 7616911319, Kerman, Iran.
   [Pourgholi, Fatemeh] Tabriz Univ Med Sci, Fac Med, Dept Immunol, Tabriz, Iran.
   [Goodarzynejad, Hamidreza] Univ Tehran Med Sci, Tehran Heart Ctr, Dept Cardiac Res, Tehran, Iran.
   [Mandegary, Ali] Kerman Univ Med Sci, Physiol Res Ctr, Inst Neuropharmacol, Kerman, Iran.
C3 Tehran University of Medical Sciences; Kerman University of Medical
   Sciences; Tabriz University of Medical Science; Tehran University of
   Medical Sciences; Kerman University of Medical Sciences
RP Mandegary, A (corresponding author), Kerman Univ Med Sci, Sch Pharm, Dept Pharmacol & Toxicol, POB 7616911319, Kerman, Iran.; Boroumand, M (corresponding author), Univ Tehran Med Sci, Tehran Heart Ctr, Dept Clin Pathol & Lab Med, POB 1411713138, Tehran, Iran.
EM maboroumand@yahoo.com; alimandegary@kmu.ac.ir
RI Goodarzynejad, Hamidreza/AFJ-2865-2022; Mandegary, Ali/O-9809-2017
OI Mandegary, Ali/0000-0002-1065-9349
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NR 32
TC 4
Z9 4
U1 0
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0014-2972
EI 1365-2362
J9 EUR J CLIN INVEST
JI Eur. J. Clin. Invest.
PD SEP
PY 2020
VL 50
IS 9
AR e13275
DI 10.1111/eci.13275
EA JUL 2020
PG 7
WC Medicine, General & Internal; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Research & Experimental Medicine
GA NG3XQ
UT WOS:000553214700001
PM 32406080
DA 2025-06-11
ER

PT J
AU Akçay, NC
   Ömeroglu, S
   Dizakar, SÖA
   Kavutçu, M
   Türkoglu, I
   Esmekaya, MA
   Peker, TV
AF Akcay, Neslihan Coskun
   Omeroglu, Suna
   Dizakar, Saadet Ozen Akarca
   Kavutcu, Mustafa
   Turkoglu, Ismail
   Esmekaya, Meric Arda
   Peker, Tuncay Veysel
TI The effects of melatonin on possible damage that will occur on
   adipocytokines and liver tissue by coadministration of fructose and
   bisphenol a (BPA)
SO ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
LA English
DT Article
DE Bisphenol A; Melatonin; Metabolic syndrome; Liver; Adipocytokine;
   Fructose
ID OXIDATIVE STRESS; VISCERAL ADIPOSITY; METABOLIC SYNDROME; DIETARY
   FRUCTOSE; ADIPONECTIN; PREVENTS; CELL; CONSUMPTION; INHIBITION;
   MECHANISMS
AB BPA, one of the environmental endocrine disruptors, and fructose, reason of liver steatosis which is frequently encountered in the daily diet, contribute to the formation of metabolic syndrome (MetS). This study examines the possible effects of concurrent fructose and BPA administration on MetS and determines the effects of melatonin on this process. In the seven identified groups, a total of forty-two adult male Sprague Dawley rats were treated by following fructose, BPA, and melatonin amounts, separately and together: group 1 (control), group 2 (10% aqueous fructose), group 3 (25 mg/kg BPA), group 4 (10% fructose + 25 mg/kg BPA), group 5 (10% fructose + 20 mg/kg melatonin), group 6 (25 mg/kg BPA + 20 mg/kg melatonin), and group 7 (10% fructose + 25 mg/kg BPA + 20 mg/kg melatonin). At the end of 60 days, histochemical, immunohistochemical, and biochemical procedures were performed on liver tissue. As a result, it was seen that BPA and fructose + BPA induced morphological alteration and inflammation and increased intracellular lipid quantity and amount of collagen and reticular fibers. The percentage of apoptotic liver cells stained by annexin V-FITC/PI was lower in group 7 compared to the group 4 (p < 0,001) and also in group 6 compared to the group 3 (p = 0.014). Both BPA and fructose application caused an increase in lipid peroxidation level due to the increase of oxidative stress. Application of melatonin induced antioxidant enzyme activity and reduced lipid peroxidation level. Our results indicate that fructose and BPA administration triggered the formation of MetS, whereas melatonin healed these variations, although not entirely.
C1 [Akcay, Neslihan Coskun] Hacettepe Univ, Dept Obstet & Gynecol, Vitro Fertilizat Unit, Fac Med, 2th Floor, TR-06230 Ankara, Turkey.
   [Omeroglu, Suna; Dizakar, Saadet Ozen Akarca; Turkoglu, Ismail] Gazi Univ, Dept Histol & Embryol, Fac Med, Deans Bldg,4th Floor, TR-06560 Ankara, Turkey.
   [Kavutcu, Mustafa] Gazi Univ, Dept Biochem, Fac Med, Deans Bldg,5th Floor, TR-06560 Ankara, Turkey.
   [Esmekaya, Meric Arda] Gazi Univ, Dept Biophys, Fac Med, Deans Bldg,5th Floor, TR-06560 Ankara, Turkey.
   [Peker, Tuncay Veysel] Gazi Univ, Dept Anat, Fac Med, Deans Bldg,2th Floor, TR-06560 Ankara, Turkey.
C3 Hacettepe University; Gazi University; Gazi University; Gazi University;
   Gazi University
RP Akçay, NC (corresponding author), Hacettepe Univ, Dept Obstet & Gynecol, Vitro Fertilizat Unit, Fac Med, 2th Floor, TR-06230 Ankara, Turkey.
EM neslihancoskun@hacettepe.edu.tr; sunaer@gazi.edu.tr;
   ozenakarca@gmail.com; kavutcu@gazi.edu.tr; ismailt.turkoglu@gmail.com;
   mericarda@yahoo.com; tpeker@gazi.edu.tr
RI Türkoğlu, İsmail/JRY-1673-2023; DİZAKAR, Saadet Özen/AAA-1367-2021;
   COSKUN AKCAY, Neslihan/JZS-9230-2024; Peker, tuncay/ABI-3436-2020
OI Turkoglu, Ismail/0000-0002-0567-5459
FU Scientific Researches Project Unit at Gazi University [01/2015-06]
FX This study was funded by the Scientific Researches Project Unit at Gazi
   University (Project number 01/2015-06).
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NR 47
TC 10
Z9 10
U1 1
U2 16
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0944-1344
EI 1614-7499
J9 ENVIRON SCI POLLUT R
JI Environ. Sci. Pollut. Res.
PD MAY
PY 2020
VL 27
IS 14
BP 16231
EP 16245
DI 10.1007/s11356-020-08041-7
EA MAR 2020
PG 15
WC Environmental Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology
GA LP3LH
UT WOS:000517720600018
PM 32124283
DA 2025-06-11
ER

PT J
AU Morrison, FG
   Logue, MW
   Guetta, R
   Maniates, H
   Stone, A
   Schichman, SA
   McGlinchey, RE
   Milberg, WP
   Miller, MW
   Wolf, EJ
AF Morrison, Filomene G.
   Logue, Mark W.
   Guetta, Rachel
   Maniates, Hannah
   Stone, Annjanette
   Schichman, Steven A.
   McGlinchey, Regina E.
   Milberg, William P.
   Miller, Mark W.
   Wolf, Erika J.
TI Investiption of bidirectional longitudinal associations between advanced
   epigenetic age and peripheral biomarkers of inflammation and metabolic
   syndrome
SO AGING-US
LA English
DT Article
DE epigenetic age; DNA methylation age; longitudinal; C-reactive protein;
   metabolic syndrome
ID POSTTRAUMATIC-STRESS-DISORDER; DNA METHYLATION AGE; ALL-CAUSE MORTALITY;
   PTSD; RISK; POPULATION; SENESCENCE; DISEASE; CANCER; LOAD
AB Epigenetic age estimations based on DNA methylation (DNAm) can predict human chronological age with a high level of accuracy. These DNAm age algorithms can also be used to index advanced cellular age, when estimated DNAm age exceeds chronological age. Advanced DNAm age has been associated with several diseases and metabolic and inflammatory pathology, but the causal direction of this association is unclear. The goal of this study was to examine potential bidirectional associations between advanced epigenetic age and metabolic and inflammatory markers over time in a longitudinal cohort of 179 veterans with a high prevalence of posttraumatic stress disorder (PTSD) who were assessed over the course of two years. Analyses focused on two commonly investigated metrics of advanced DNAm age derived from the Horvath (developed across multiple tissue types) and Hannum (developed in whole blood) DNAm age algorithms. Results of cross-lagged panel models revealed that advanced Hannum DNAm age at Time 1 (T1) was associated with increased (i.e., accounting for T1 levels) metabolic syndrome (MetS) severity at Time 2 (T2; p = < 0.001). This association was specific to worsening lipid panels and indicators of abdominal obesity (p = 0.001). In contrast, no baseline measures of inflammation or metabolic pathology were associated with changes in advanced epigenetic age over time. No associations emerged between advanced Horvath DNAm age and any of the examined biological parameters. Results suggest that advanced epigenetic age, when measured using an algorithm developed in whole blood, may be a prognostic marker of pathological metabolic processes. This carries implications for understanding pathways linking advanced epigenetic age to morbidity and mortality.
C1 [Morrison, Filomene G.; Logue, Mark W.; Guetta, Rachel; Maniates, Hannah; Miller, Mark W.; Wolf, Erika J.] VA Boston Healthcare Syst, Natl Ctr, PTSD, Boston, MA 02130 USA.
   [Morrison, Filomene G.; Logue, Mark W.; Miller, Mark W.; Wolf, Erika J.] Boston Univ, Sch Med, Dept Psychiat, Boston, MA 02118 USA.
   [Logue, Mark W.] Boston Univ, Sch Med, Biomed Genet, Boston, MA 02118 USA.
   [Stone, Annjanette; Schichman, Steven A.] Cent Arkansas Vet Healthcare Syst, Res Serv, Pharmacogen Anal Lab, Little Rock, AR 72205 USA.
   [McGlinchey, Regina E.; Milberg, William P.] VA Boston Healthcare Syst, Geriatr Res Educ & Clin Ctr, Boston, MA 02130 USA.
   [McGlinchey, Regina E.; Milberg, William P.] VA Boston Healthcare Syst, Translat Res Ctr TBI & Stress Disorders, Boston, MA 02130 USA.
   [McGlinchey, Regina E.; Milberg, William P.] Harvard Med Sch, Dept Psychiat, Boston, MA 02115 USA.
C3 Harvard University; Harvard University Medical Affiliates; US Department
   of Veterans Affairs; Veterans Health Administration (VHA); VA Boston
   Healthcare System; Boston University; Boston University; US Department
   of Veterans Affairs; Veterans Health Administration (VHA); Central
   Arkansas Veterans Healthcare System; Geriatric Research Education &
   Clinical Center; Harvard University; Harvard University Medical
   Affiliates; US Department of Veterans Affairs; Veterans Health
   Administration (VHA); VA Boston Healthcare System; Harvard University;
   Harvard University Medical Affiliates; US Department of Veterans
   Affairs; Veterans Health Administration (VHA); VA Boston Healthcare
   System; Harvard University; Harvard Medical School
RP Wolf, EJ (corresponding author), VA Boston Healthcare Syst, Natl Ctr, PTSD, Boston, MA 02130 USA.; Wolf, EJ (corresponding author), Boston Univ, Sch Med, Dept Psychiat, Boston, MA 02118 USA.
EM Erika.Wolf@va.gov
RI Miller, Mark/G-7322-2011; McGlinchey, Regina/R-1971-2016
OI Wolf, Erika/0000-0003-2666-2435; Guetta, Rachel/0000-0002-7271-9917
FU Merit Review Award from United States (U.S.) Department of Veterans
   Affairs Clinical Sciences R&D (CSRD) Service [I01 CX-001276-01];
   Presidential Early Career Award for Scientists and Engineers (PECASE
   2013A); NIA [R0350204413]; NIMH [R21MH102834]; Translational Research
   Center for TBI and Stress Disorders (TRACTS), a VA Rehabilitation
   Research and Development Traumatic Brain Injury Center of Excellence
   [B9254-C]; Cooperative Studies Program, Department of Veterans Affairs;
   National Institute of Mental Health award [5T32MH019836-18]
FX This work was supported by Merit Review Award Number I01 CX-001276-01
   from the United States (U.S.) Department of Veterans Affairs Clinical
   Sciences R&D (CSRD) Service and by a Presidential Early Career Award for
   Scientists and Engineers (PECASE 2013A) to EJW, as administered by U.S.
   Department of Veterans Affairs Office of Research and Development.
   Funding for this work is also supported by NIA R0350204413 to EJW, NIMH
   grant R21MH102834 to MWM and the Translational Research Center for TBI
   and Stress Disorders (TRACTS), a VA Rehabilitation Research and
   Development Traumatic Brain Injury Center of Excellence (B9254-C), and
   the Cooperative Studies Program, Department of Veterans Affairs. FGM's
   contribution to this work was supported by National Institute of Mental
   Health award #5T32MH019836-18.
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NR 59
TC 22
Z9 23
U1 0
U2 8
PU IMPACT JOURNALS LLC
PI ORCHARD PARK
PA 6666 E QUAKER ST, STE 1, ORCHARD PARK, NY 14127 USA
SN 1945-4589
J9 AGING-US
JI Aging-US
PD JUN 15
PY 2019
VL 11
IS 11
BP 3487
EP 3504
DI 10.18632/aging.101992
PG 18
WC Cell Biology; Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Cell Biology; Geriatrics & Gerontology
GA ID6ON
UT WOS:000471798500009
PM 31173577
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Kornicka, K
   Szlapka-Kosarzewska, J
   Smieszek, A
   Marycz, K
AF Kornicka, Katarzyna
   Szlapka-Kosarzewska, Jolanta
   Smieszek, Agnieszka
   Marycz, Krzysztof
TI 5-Azacytydine and resveratrol reverse senescence and ageing of adipose
   stem cells via modulation of mitochondrial dynamics and autophagy
SO JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
LA English
DT Article
DE adipose-derived mesenchymal stem cells; autophagy; metabolic syndrome;
   mitochondria; mitophagy; stem cells
ID ENDOPLASMIC-RETICULUM STRESS; OXIDATIVE STRESS; INSULIN SENSITIVITY;
   METABOLIC SYNDROME; GENE-EXPRESSION; DNA METHYLATION; DIFFERENTIATION;
   OSTEOGENESIS; CYTOKINE; PROTECTS
AB Obesity and endocrine disorders have become prevalent issues in the field of both human and veterinary medicine. Equine metabolic syndrome is a complex disorder involving alternation in metabolism and chronic systemic inflammation. It has been shown that unfavourable microenvironment of inflamed adipose tissue negatively affects adipose stem cell population (ASC) residing within, markedly limiting their therapeutic potential. ASCs(EMS) are characterized by increased senescence apoptosis, excessive accumulation of reactive oxygen species (ROS), mitochondria deterioration and "autophagic flux." The aim of the present study was to evaluate whether treatment of ASCs(EMS) with a combination of 5-azacytydine (AZA) and resveratrol (RES) would reverse aged phenotype of these cells. For this reason, we performed the following analyzes: molecular biology (RT-PCR), microscopic (immunofluorescence, TEM) and flow cytometry (JC-1, ROS, Ki67). We evaluated the mitochondrial status, dynamics and clearance as well as autophagic pathways. Furthermore, we investigated epigenetic alternations in treated cells by measuring the expression of TET genes and analysis of DNA methylation status. We have demonstrated that AZA/RES treatment of ASCs(EMS) is able to rejuvenate these cells by modulating mitochondrial dynamics, in particular by promoting mitochondrial fusion over fission. After AZA/RES treatment, ASCs(EMS) were characterized by increased proliferation rate, decreased apoptosis and senescence and lower ROS accumulation. Our findings offer a novel approach and potential targets for the beneficial effects of AZA/RES in ameliorating stem cell dysfunctions.
C1 [Kornicka, Katarzyna; Szlapka-Kosarzewska, Jolanta; Smieszek, Agnieszka; Marycz, Krzysztof] Univ Environm & Life Sci Wroclaw, Fac Biol & Anim Sci, Dept Expt Biol, Wroclaw, Poland.
   [Marycz, Krzysztof] Justus Liebig Univ, Equine Clin, Fac Vet Med, Equine Surg, Giessen, Germany.
C3 Wroclaw University of Environmental & Life Sciences; Justus Liebig
   University Giessen
RP Kornicka, K (corresponding author), Univ Environm & Life Sci Wroclaw, Fac Biol & Anim Sci, Dept Expt Biol, Wroclaw, Poland.
EM katarzyna.kornicka@upwr.edu.pl
RI Smieszek, Agnieszka/A-4887-2017
OI Smieszek, Agnieszka/0000-0002-7314-9821
FU Narodowe Centrum Nauki [2016/21/B/NZ7/01111]
FX Narodowe Centrum Nauki, Grant/Award Number: 2016/21/B/NZ7/01111
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NR 64
TC 64
Z9 72
U1 0
U2 22
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
EI 1582-4934
J9 J CELL MOL MED
JI J. Cell. Mol. Med.
PD JAN
PY 2019
VL 23
IS 1
BP 237
EP 259
DI 10.1111/jcmm.13914
PG 23
WC Cell Biology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Research & Experimental Medicine
GA HF7MI
UT WOS:000454423300021
PM 30370650
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Morita, Y
   Ohta, M
   Inoue, T
   Honda, T
   Konno, Y
   Eguchi, Y
   Yamato, H
AF Morita, Yusaku
   Ohta, Masanori
   Inoue, Tomohiro
   Honda, Toru
   Konno, Yoshimasa
   Eguchi, Yasumasa
   Yamato, Hiroshi
TI Sense of coherence is significantly associated with both metabolic
   syndrome and lifestyle in Japanese computer software office workers
SO INTERNATIONAL JOURNAL OF OCCUPATIONAL MEDICINE AND ENVIRONMENTAL HEALTH
LA English
DT Article
DE Metabolic syndrome; Lifestyle; Sense of coherence; Job stressor;
   Atherosclerotic risk factors
ID BODY-MASS INDEX; CORONARY-HEART-DISEASE; MYOCARDIAL-INFARCTION;
   ANTONOVSKYS SENSE; JOB STRESS; HEALTH; MORTALITY; RISK; ENVIRONMENT;
   SMOKING
AB Sense of coherence (SOC) is an individual characteristic related to a positive life orientation, leading to effective coping. Little is known about the relationship between SOC and metabolic syndrome (MetS). This cross-sectional study aimed at testing the hypothesis that workers with a strong SOC have fewer atherosclerotic risk factors, including MetS, and healthier lifestyle behaviors.
   One hundred and sixty-seven computer software workers aged 20-64 years underwent a periodical health examination including assessment of body mass index, waist circumference, blood pressure, blood lipid levels, fasting blood sugar (FBS) levels and lifestyle behaviors (walking duration, smoking status, nutrition, alcohol consumption, and sleep duration). During this period, the participants also completed a 29-item questionnaire of SOC and the Brief Job Stress Questionnaire to assess job stressors such as job strain and workplace social support.
   Our results showed that the participants with a stronger SOC were likely to walk for at least 1 h a day, to eat slowly or at a moderate speed, and to sleep for at least 6 h. Compared with the participants with the weakest SOC, those with the strongest SOC had a significantly lower odds ratio (OR) for being overweight (OR = 0.31; 95% confidence interval (CI): 0.11-0.81), and having higher FBS levels (OR = 0.11; 95% CI: 0.02-0.54), dyslipidemia (OR = 0.29; 95% CI: 0.09-0.84), and MetS (OR = 0.12; 95% CI: 0.02-0.63), even after adjusting for age, gender and job stressors.
   High SOC is associated with a healthy lifestyle and fewer atherosclerotic risk factors, including MetS.
C1 [Morita, Yusaku; Ohta, Masanori; Inoue, Tomohiro; Honda, Toru; Konno, Yoshimasa; Eguchi, Yasumasa; Yamato, Hiroshi] Univ Occupat & Environm Hlth, Inst Ind Ecol Sci, Dept Hlth Dev, Kitakyushu, Fukuoka 8078555, Japan.
C3 University of Occupational & Environmental Health - Japan
RP Morita, Y (corresponding author), Univ Occupat & Environm Hlth, Inst Ind Ecol Sci, Dept Hlth Dev, Yahatanishi Ku, 1-1 Iseigaoka, Kitakyushu, Fukuoka 8078555, Japan.
EM morita@med.uoeh-u.ac.jp
RI Ohta, M./AAO-6885-2020; Morita, Yusaku/AAZ-8698-2021
OI Morita, Yusaku/0000-0002-5828-3483; Ohta, Masanori/0000-0001-9642-514X
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NR 40
TC 14
Z9 14
U1 1
U2 10
PU NOFER INST OCCUPATIONAL MEDICINE, POLAND
PI LODZ
PA SW TERESY 8, LODZ, 91-348, POLAND
SN 1232-1087
EI 1896-494X
J9 INT J OCCUP MED ENV
JI Int. J. Occup. Med. Environ. Health
PD DEC
PY 2014
VL 27
IS 6
BP 967
EP 979
DI 10.2478/s13382-014-0322-4
PG 13
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA AY6ND
UT WOS:000347682000008
PM 25556337
OA gold
DA 2025-06-11
ER

PT J
AU Akase, T
   Nagase, T
   Huang, LJ
   Ibuki, A
   Minematsu, T
   Nakagami, G
   Ohta, Y
   Shimada, T
   Aburada, M
   Sugama, J
   Sanada, H
AF Akase, Tomoko
   Nagase, Takashi
   Huang, Lijuan
   Ibuki, Ai
   Minematsu, Takeo
   Nakagami, Gojiro
   Ohta, Yasunori
   Shimada, Tsutomu
   Aburada, Masaki
   Sugama, Junko
   Sanada, Hiromi
TI Aging-Like Skin Changes Induced by Ultraviolet Irradiation in an Animal
   Model of Metabolic Syndrome
SO BIOLOGICAL RESEARCH FOR NURSING
LA English
DT Article
DE aging; skin; ultraviolet irradiation; metabolic syndrome
ID MOUSE; DAMAGE; RESISTANCE; COLLAGEN
AB Both physiological skin aging and pathologic photo-aging caused by ultraviolet (UV) irradiation are mediated by latent inflammation and oxidative stress. Although numerous animal skin-aging models have used UV irradiation, most require massive doses or long-term irradiation. To establish a more refined skin-aging model, we focused on an animal model of metabolic syndrome (MS) because MS involves damage to various organs via oxidative stress or inflammation, similar to the changes associated with aging. We hypothesized that MS skin might exhibit more aging-like changes after milder, shorter-term UV irradiation than would normal animal skin under similar conditions, thus providing a useful model for skin aging. The authors therefore examined the skin from Tsumura Suzuki obese diabetic (TSOD) mice (MS model) and control Tsumura Suzuki non-obese (TSNO) mice before and after UV irradiation. Skin from TSOD mice had a thinner epidermis and dermis, a thicker fatty layer, reduced density and convolution of the fragmented collagen fibers, and upregulated expression of tumor necrosis factor (TNF)-alpha, a dual marker for inflammation and aging, compared to the skin from TSNO mice. UV irradiation affected TSOD skin more severely than TSNO skin, resulting in various changes resembling those in aged human skin, including damage to the dermis and subcutaneous fatty tissue, infiltration of inflammatory cells, and further upregulation of TNF-alpha expression. These results suggest that UV-irradiated TSOD mice may provide a new model of skin aging and imply that skin from humans with MS is more susceptible to UV- or aging-related damage than normal human skin.
C1 [Sanada, Hiromi] Univ Tokyo, Grad Sch Med, Dept Gerontol Nursing Wound Care Management, Div Hlth Sci & Nursing,Bunkyo Ku, Tokyo 1130033, Japan.
   [Minematsu, Takeo; Sugama, Junko] Univ Tokyo, Grad Sch Med, Dept Adv Skin Care Miss Paris, Tokyo 1130033, Japan.
   [Ohta, Yasunori] Toranomon Gen Hosp, Dept Pathol, Tokyo, Japan.
   [Shimada, Tsutomu; Aburada, Masaki] Musashino Univ, Pharmaceut Sci Res Inst, Tokyo, Japan.
C3 University of Tokyo; University of Tokyo; Toranomon Hospital
RP Sanada, H (corresponding author), Univ Tokyo, Grad Sch Med, Dept Gerontol Nursing Wound Care Management, Div Hlth Sci & Nursing,Bunkyo Ku, 7-3-1 Hongo, Tokyo 1130033, Japan.
EM hsanada-tky@umin.ac.jp
RI SUGAMA, Junko/J-8410-2015; Nakagami, Gojiro/V-9093-2019
OI Nakagami, Gojiro/0000-0002-9650-2464; Minematsu,
   Takeo/0000-0001-5859-7290
FU MEXT (Ministry of Education Culture, Sports, Science and Technology)
   [21659494]; Grants-in-Aid for Scientific Research [21659494] Funding
   Source: KAKEN
FX The authors disclosed receipt of the following financial support for the
   research and/or authorship of this article: This work was supported by a
   grant-in-aid for scientific research from MEXT (Ministry of Education
   Culture, Sports, Science and Technology; No. 21659494).
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NR 33
TC 23
Z9 24
U1 0
U2 17
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1099-8004
EI 1552-4175
J9 BIOL RES NURS
JI Biol. Res. Nurs.
PD APR
PY 2012
VL 14
IS 2
BP 180
EP 187
DI 10.1177/1099800411401013
PG 8
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nursing
GA 930HL
UT WOS:000303128200009
PM 21444332
DA 2025-06-11
ER

PT J
AU Park, SK
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   Nie, HL
   Hu, H
AF Park, Sung Kyun
   Schwartz, Joel
   Weisskopf, Marc
   Sparrow, David
   Vokonas, Pantel S.
   Wright, Robert O.
   Coull, Brent
   Nie, Huiling
   Hu, Howard
TI Low-level lead exposure, metabolic syndrome, and heart rate variability:
   The VA Normative Aging Study
SO ENVIRONMENTAL HEALTH PERSPECTIVES
LA English
DT Article
DE autonomic nervous system; bone lead; heart rate variability;
   hypertension; metabolic syndrome
ID CARDIOVASCULAR-DISEASE; BLOOD-PRESSURE; LIPID-PEROXIDATION;
   ATHEROSCLEROSIS RISK; AUTONOMIC FUNCTION; OXIDATIVE STRESS;
   RENAL-FUNCTION; NITRIC-OXIDE; BONE LEAD; HYPERTENSION
AB BACKGROUND: Altered heart rate variability (HRV), a marker of poor cardiac autonomic function, has been associated with sudden cardiac death and heart failure.
   OBJECTIVE: We examined the association of low-level lead exposure measured in bone by K-X-ray fluorescence with alterations in HRV, and whether metabolic syndrome (MetS) or its individual components modify those associations.
   METHODS: HRV measures [power in high-frequency (HFnorm) and low-frequency (LFnorm) in normalized units, and LF/HF] were taken among 413 elderly men from the Normative Aging Study. MetS was defined as subjects having three or more of the following criteria: abdominal obesity, hypertriglyceridemia, low high-density lipoprotein, high blood pressure, and high fasting glucose.
   RESULTS: Of the subjects, 32% were identified as having MetS. Inverse but nonstatistically significant associations of both tibia and patella lead levels with HFnorm and nonstatistically significant positive relations with LFnorm and LF/HF were found in the entire cohort. There was a graded, statistically significant reduction in HFnorm and increases in LFnorm and LF/HF in association with an increase in patella lead as the number of metabolic abnormalities increased. We also observed that higher patella lead was consistently associated with lower HFnorm, and higher LFnorm and LF/HF among subjects with MetS or its individual components. No statistically significant interaction between MetS and tibia lead was observed.
   CONCLUSION: The results suggest that elderly men with MetS were more susceptible to autonomic dysfunction in association with chronic lead exposure as measured in patella. The modification by MetS is consistent with a role for oxidative stress in lead toxicity on the cardiovascular system.
C1 Harvard Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA 02115 USA.
   Harvard Univ, Sch Med, Brigham & Womens Hosp, Dept Med,Channing Lab, Boston, MA 02115 USA.
   Harvard Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA.
   Boston Univ, Sch Med, VA Normat Aging, Vet Affairs Boston Healthcare Syst, Boston, MA 02215 USA.
   Boston Univ, Sch Med, Dept Med, Boston, MA 02118 USA.
C3 Harvard University; Harvard T.H. Chan School of Public Health; Harvard
   University; Harvard University Medical Affiliates; Brigham & Women's
   Hospital; Harvard Medical School; Harvard University; Harvard T.H. Chan
   School of Public Health; Boston University; Harvard University; Harvard
   University Medical Affiliates; US Department of Veterans Affairs;
   Veterans Health Administration (VHA); VA Boston Healthcare System;
   Boston University
RP Park, SK (corresponding author), Univ Michigan, Sch Publ Hlth, Dept Environm Hlth Sci, SPH 2,M6240,109 S Observ St, Ann Arbor, MI 48109 USA.
EM sungkyun@umich.edu
RI Schwartz, Joel/JRY-6780-2023; Hu, Howard/AAV-5360-2021
OI Hu, Howard/0000-0002-3676-2707; Park, Sung Kyun/0000-0001-9981-6250
FU NIEHS NIH HHS [R01 ES010798, ES05257, T32 ES07069, ES10798, P42-ES05947,
   P30 ES000002, P42 ES005947, T32 ES007069, ES00002, R01 ES005257] Funding
   Source: Medline
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NR 48
TC 67
Z9 75
U1 0
U2 11
PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE
PI RES TRIANGLE PK
PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233,
   RES TRIANGLE PK, NC 27709-2233 USA
SN 0091-6765
EI 1552-9924
J9 ENVIRON HEALTH PERSP
JI Environ. Health Perspect.
PD NOV
PY 2006
VL 114
IS 11
BP 1718
EP 1724
DI 10.1289/ehp.8992
PG 7
WC Environmental Sciences; Public, Environmental & Occupational Health;
   Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health; Toxicology
GA 102OS
UT WOS:000241822300033
PM 17107858
OA Green Submitted, Green Published, gold, Green Accepted
DA 2025-06-11
ER

PT J
AU Peixoto-Silva, N
   Conceiçao, EPS
   Carvalho, JC
   Lima, NS
   Nogueira-Neto, JF
   de Oliveira, E
   Moura, EG
   Lisboa, PC
AF Peixoto-Silva, Nayara
   Conceicao, Ellen P. S.
   Carvalho, Janaine C.
   Lima, Natalia S.
   Nogueira-Neto, Jose Firmino
   de Oliveira, Elaine
   Moura, Egberto G.
   Lisboa, Patricia C.
TI Does bromocriptine play a role in decreasing oxidative stress for early
   weaned programmed obesity?
SO LIFE SCIENCES
LA English
DT Article
DE Early weaning; Bromocriptine; Obesity; Liver disease; Antioxidant system
ID MATERNAL PROLACTIN INHIBITION; LACTATION PROGRAMS; METABOLIC SYNDROME;
   LEPTIN RESISTANCE; RATS; MODEL; DYSFUNCTION; STEATOSIS; SIRTUINS; FAT
AB Aims: Studies have demonstrated that early weaning can promote metabolic syndrome during adulthood and that obesity increases oxidative stress. Thus, we aimed to evaluate redox status in a pharmacological early weaning rodent model programmed for metabolic syndrome at adulthood.
   Main methods: Lactating dams were randomly assigned into 2 groups: the early weaning group (BRO), which was treated intraperitoneally with bromocriptine (1 mg/day) to inhibit prolactin secretion for the last 3 days of lactation, and the control group (C), which received the BRO diluent for the same time period. The offspring were killed at 90 (PN90) and 180 (PN180) days after birth.
   Key findings: Early weaning induced greater visceral adiposity and dyslipidemia. At PN90, the BRO offspring showed glucose intolerance with normoinsulinemia and increased plasma and liver superoxide dismutase, and liver glutathione peroxidase activities, which reduced the liver malondialdehyde but not the increased plasma malondialdehyde levels. However, the BRO offspring showed insulin resistance at PN180 and increased plasma glutathione peroxidase, liver superoxide dismutase, and catalase activities. These changes reduced the plasma and liver malondialdehyde levels, which aided in hepatocyte architecture preservation. Additionally, we observed that sirtuin 1 was overexpressed in the BRO group at PN90, but the increased expression was not maintained through PN180, which suggests unfavorable metabolic conditions in the older offspring.
   Significance: Despite the observed obesity and glucose homeostasis dysfunction, our data suggest that the early weaning programming induced by bromocriptine can improve the offspring's redox status and may prevent liver damage during adulthood. (C) 2013 Elsevier Inc All rights reserved.
C1 [Peixoto-Silva, Nayara; Conceicao, Ellen P. S.; Carvalho, Janaine C.; Lima, Natalia S.; de Oliveira, Elaine; Moura, Egberto G.; Lisboa, Patricia C.] Roberto Alcantara Gomes Biol Inst, Dept Physiol Sci, Rio De Janeiro, Brazil.
   [Nogueira-Neto, Jose Firmino] Univ Estado Rio De Janeiro, Sch Med, Lab Lipids, Rio De Janeiro, Brazil.
C3 Universidade do Estado do Rio de Janeiro
RP Lisboa, PC (corresponding author), Univ Estado Rio de Janeiro, Dept Ciencias Fisiol, Inst Biol, 5 Andar,Av 28 Setembro 87, BR-20551030 Rio De Janeiro, RJ, Brazil.
EM pclisboa@uerj.br
RI Moura, Egberto/ABA-6188-2021; Peixoto-Silva, Nayara/P-5072-2015; Lima,
   Natalia Sarmanho/KMA-7618-2024; Lisboa, Patricia/H-8336-2015; Moura,
   Egberto/H-1270-2012
OI Lisboa, Patricia/0000-0002-2477-4364; Conceicao Furber,
   Ellen/0000-0003-0370-1032; Moura, Egberto/0000-0002-1159-7549
FU National Council for Scientific and Technological Development (Conselho
   Nacional de Desenvolvimento Cientifico e Tecnologico - CNPq);
   Coordination for the Enhancement of Higher Education Personnel
   (Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior -CAPES);
   State of Rio de Janeiro Carlos Chagas Filho Research Foundation
   (Fundacao Carlos Chagas Filho de Amparo a Pesquisa do Estado do Rio de
   Janeiro -FAPERJ)
FX All authors are grateful to Miss Monica Moura and Mr. Ulisses Risso
   Siqueira for technical assistance. This research was supported by the
   National Council for Scientific and Technological Development (Conselho
   Nacional de Desenvolvimento Cientifico e Tecnologico - CNPq), the
   Coordination for the Enhancement of Higher Education Personnel
   (Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior -CAPES) and
   the State of Rio de Janeiro Carlos Chagas Filho Research Foundation
   (Fundacao Carlos Chagas Filho de Amparo a Pesquisa do Estado do Rio de
   Janeiro -FAPERJ).
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NR 29
TC 13
Z9 13
U1 0
U2 10
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0024-3205
EI 1879-0631
J9 LIFE SCI
JI Life Sci.
PD JAN 24
PY 2014
VL 95
IS 1
BP 14
EP 21
DI 10.1016/j.lfs.2013.12.013
PG 8
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA 297MS
UT WOS:000330260200003
PM 24361363
DA 2025-06-11
ER

PT J
AU Singhal, J
   Nagaprashantha, L
   Vatsyayan, R
   Awasthi, S
   Singhal, SS
AF Singhal, Jyotsana
   Nagaprashantha, Lokesh
   Vatsyayan, Rit
   Awasthi, Sanjay
   Singhal, Sharad S.
TI RLIP76, a Glutathione-Conjugate Transporter, Plays a Major Role in the
   Pathogenesis of Metabolic Syndrome
SO PLOS ONE
LA English
DT Article
ID ATP-DEPENDENT TRANSPORT; OXIDATIVE STRESS; FRUCTOSE 1,6-DIPHOSPHATASE;
   INSULIN-SECRETION; SKELETAL-MUSCLE; PROTEIN; LIVER; ENDOCYTOSIS;
   INHIBITION; EXPRESSION
AB Purpose: Characteristic hypoglycemia, hypotriglyceridemia, hypocholesterolemia, lower body mass, and fat as well as pronounced insulin-sensitivity of RLIP76(-/-) mice suggested to us the possibility that elevation of RLIP76 in response to stress could itself elicit metabolic syndrome (MSy). Indeed, if it were required for MSy, drugs used to treat MSy should have no effect on RLIP76(-/-) mice.
   Research Design and Methods: Blood glucose (BG) and lipid measurements were performed in RLIP76(+/+) and RLIP76(-/-) mice, using Ascensia Elite Glucometer (R) for glucose and ID Labs kits for cholesterol and triglycerides assays. The ultimate effectors of gluconeogenesis are the three enzymes: PEPCK, F-1,6-BPase, and G6Pase, and their expression is regulated by PPAR gamma and AMPK. The activity of these enzymes was tested by protocols standardized by us. Expressions of RLIP76, PPAR alpha, PPAR gamma, HMGCR, pJNK, pAkt, and AMPK were performed by Western-blot and tissue staining.
   Results: The concomitant activation of AMPK and PPAR gamma by inhibiting transport activity of RLIP76, despite inhibited activity of key glucocorticoid-regulated hepatic gluconeogenic enzymes like PEPCK, G6Pase and F-1,6-BP in RLIP76(-/-) mice, is a salient finding of our studies. The decrease in RLIP76 protein expression by rosiglitazone and metformin is associated with an up-regulation of PPAR gamma and AMPK.
   Conclusions/Significance: All four drugs, rosiglitazone, metformin, gemfibrozil and atorvastatin failed to affect glucose and lipid metabolism in RLIP76(-/-) mice. Studies confirmed a model in which RLIP76 plays a central role in the pathogenesis of MSy and RLIP76 loss causes profound and global alterations of MSy signaling functions. RLIP76 is a novel target for single-molecule therapeutics for metabolic syndrome.
C1 [Singhal, Jyotsana; Nagaprashantha, Lokesh; Awasthi, Sanjay; Singhal, Sharad S.] Natl Med Ctr, Beckman Res Inst, Dept Diabet & Metab Dis Res, Duarte, CA USA.
   [Vatsyayan, Rit] Univ N Texas, Hlth Sci Ctr, Dept Mol Biol & Immunol, Ft Worth, TX USA.
C3 City of Hope; Beckman Research Institute of City of Hope; University of
   North Texas System; University of North Texas Health Science Center
RP Singhal, J (corresponding author), Natl Med Ctr, Beckman Res Inst, Dept Diabet & Metab Dis Res, Duarte, CA USA.
EM ssinghal@coh.org
RI Nagaprashantha, Lokesh/A-6661-2012; Awasthi, Sanjay/R-4904-2019;
   Singhal, Ashutosh/H-6725-2019
OI Dalasanur Nagaprashantha, Lokesh PG/0000-0001-7041-1970; Singhal,
   Jyotsana/0009-0004-0119-9370; Awasthi, Sanjay/0000-0002-5214-5717
FU National Institutes of Health [CA 77495]; Cancer Research Foundation of
   North Texas
FX This work was supported in part by National Institutes of Health Grant
   CA 77495 and Cancer Research Foundation of North Texas. The funders had
   no role in study design, data collection and analysis, decision to
   publish, or preparation of the manuscript.
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NR 54
TC 41
Z9 44
U1 0
U2 6
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD SEP 13
PY 2011
VL 6
IS 9
AR e24688
DI 10.1371/journal.pone.0024688
PG 11
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 825ZV
UT WOS:000295321800049
PM 21931813
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Kosinski, C
   Rossel, JB
   Gross, J
   Helbling, C
   Quansah, DY
   Collet, TH
   Puder, JJ
AF Kosinski, Christophe
   Rossel, Jean-Benoit
   Gross, Justine
   Helbling, Celine
   Quansah, Dan Yedu
   Collet, Tinh-Hai
   Puder, Jardena J.
TI Adverse metabolic outcomes in the early and late postpartum after
   gestational diabetes are broader than glucose control
SO BMJ OPEN DIABETES RESEARCH & CARE
LA English
DT Article; Proceedings Paper
CT International DIP Symposium on Diabetes, Hypertension, Metabolic
   Syndrome and Preganancy
CY MAY 29-JUN 01, 2019
CL Florence, ITALY
ID LONG-TERM RISK; WEIGHT CHANGE; WOMEN; HISTORY; DEPRESSION; PREDICTORS;
   PREGNANCY; MELLITUS; GDM
AB Introduction: Gestational diabetes mellitus is associated with an increased cardiovascular risk. To better target preventive measures, we performed an in-depth characterization of cardiometabolic risk factors in a cohort of women with gestational diabetes in the early (6-8 weeks) and late (1 year) postpartum.
   Research design and methods: Prospective cohort of 622 women followed in a university gestational diabetes clinic between 2011 and 2017. 162 patients who attended the late postpartum visit were analyzed in a nested long-term cohort starting in 2015. Metabolic syndrome (MetS) was based on the International Diabetes Federation definition, and then having at least two additional criteria of the MetS (blood pressure, triglycerides, high-density lipoprotein (HDL) cholesterol, plasma glucose above or below the International Diabetes Federation cut-offs).
   Results: Compared with prepregnancy, weight retention was 4.8 +/- 6.0 kg in the early postpartum, and the prevalence of obesity, pre-diabetes, MetS-body mass index (BMI) and MetS-waist circumference (WC) were 28.8%, 28.9%, 10.3% and 23.8%, respectively. Compared with the early postpartum, weight did not change and waist circumference decreased by 2.6 +/- 0.6 cm in the late postpartum. However, the prevalence of obesity, pre-diabetes, MetS-WC and MetS-BMI increased (relative increase: 11% for obesity, 82% for pre-diabetes, 50% for MetS-WC, 100% for MetS-BMI; all p <= 0.001).
   Predictors for obesity were the use of glucose-lowering treatment during pregnancy and the prepregnancy BMI. Predictors for pre-diabetes were the early postpartum fasting glucose value and family history of diabetes. Finally, systolic blood pressure in pregnancy and in the early postpartum, the 2-hour post oral glucose tolerance test glycemia and the HDL-cholesterol predicted the development of MetS (all p<0.05).
   Conclusions: The prevalence of metabolic complications increased in the late postpartum, mainly due to an increase in fasting glucose and obesity, although weight did not change. We identified predictors of late postpartum obesity, pre-diabetes and MetS that could lead to high-risk identification and targeted preventions.
C1 [Kosinski, Christophe; Gross, Justine; Helbling, Celine; Collet, Tinh-Hai] Lausanne Univ Hosp, Serv Endocrinol Diabet & Metab, Lausanne, Switzerland.
   [Kosinski, Christophe; Rossel, Jean-Benoit; Gross, Justine; Helbling, Celine; Quansah, Dan Yedu; Collet, Tinh-Hai; Puder, Jardena J.] Univ Lausanne, Lausanne, Switzerland.
   [Rossel, Jean-Benoit; Gross, Justine; Quansah, Dan Yedu; Puder, Jardena J.] Lausanne Univ Hosp, Serv Obstet, Dept Woman Mother Child, Lausanne, Switzerland.
   [Collet, Tinh-Hai] Geneva Univ Hosp, Serv Endocrinol Diabetol Nutr & Therapeut Educ, Geneva, Switzerland.
C3 University of Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV);
   University of Lausanne; University of Lausanne; Centre Hospitalier
   Universitaire Vaudois (CHUV); University of Geneva
RP Kosinski, C (corresponding author), Lausanne Univ Hosp, Serv Endocrinol Diabet & Metab, Lausanne, Switzerland.; Kosinski, C (corresponding author), Univ Lausanne, Lausanne, Switzerland.
EM christophe.kosinski@chuv.ch
RI Collet, Tinh-Hai/I-4462-2019; Kosinski, Christophe/ABB-6319-2021;
   Quansah, Dan/B-8499-2018
OI Rossel, Jean-Benoit/0000-0001-5803-3233; Quansah,
   Dan/0000-0002-3091-9400; Kosinski, Christophe/0000-0002-7544-498X;
   Collet, Tinh-Hai/0000-0002-3243-1222; Puder, Jardena/0000-0002-0460-7614
FU Swiss National Science Foundation [SNF 32003B-176119]; Leenaards
   Foundation; Vontobel Foundation; Swiss Society of Endocrinology and
   Diabetes; Swiss Multiple Sclerosis Society; Novo Nordisk
FX This study is a pilot of a project grant by the Swiss National Science
   Foundation (SNF 32003B--176119). The cohort database received an
   unrestricted educational grant from Novo Nordisk. T--HC research is
   supported by grants from the Swiss National Science Foundation, the
   Leenaards Foundation, the Vontobel Foundation, the Swiss Society of
   Endocrinology and Diabetes, and the Swiss Multiple Sclerosis Society.
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NR 50
TC 4
Z9 4
U1 0
U2 5
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
EI 2052-4897
J9 BMJ OPEN DIAB RES CA
JI BMJ Open Diab. Res. Care
PD NOV
PY 2021
VL 9
IS 2
AR e002382
DI 10.1136/bmjdrc-2021-002382
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Endocrinology & Metabolism
GA WU4HB
UT WOS:000716506600001
PM 34750153
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Dongre, P
   Majumdar, A
AF Dongre, Prashant
   Majumdar, Anuradha
TI Network pharmacology analysis of Chandraprabha Vati: A new
   hope for the treatment of Metabolic Syndrome
SO JOURNAL OF AYURVEDA AND INTEGRATIVE MEDICINE
LA English
DT Article
DE Network pharmacology; Metabolic syndrome (MetS); Chandraprabha vati
   (CPV); Binding DB; Cytoscape; GO enrichment
ID ANTIDIABETIC ACTIVITY; CYPERUS-ROTUNDUS; DRUG DISCOVERY; INFLAMMATION;
   HYPERLIPIDEMIA; CROSSTALK; RECEPTORS; EXTRACT; INSULIN; OBESITY
AB Background: Drug research is increasingly using Network Pharmacology (NP) to tackle complex conditions like Metabolic Syndrome (MetS), which is characterized by obesity, hyperglycemia, and dyslipidemia. Single-action drugs are inadequate to treat MetS, which is marked by a range of complications including glucose intolerance, hyperlipidemia, mitochondrial dysfunction, and inflammation. Objectives: To analyze Chandraprabha vati using Network Pharmacology to assess its potential in alleviating MetSrelated complications. Material and methods: The genes related to MetS, inflammation, and the target genes of the CPV components were identified using network pharmacology tools like DisgNET and BindingDB. Followed by mapping of the CPV target genes with the genes implicated in MetS and inflammation to identify putative potential targets. Gene ontology, pathway enrichment analysis, and STRING database were employed for further exploration. Furthermore, drug-target-protein interactions network were visualized using Cytoscape 3.9.1. Results: The results showed that out of the 225 target genes of the CPV components, 33 overlapping and 19 nonoverlapping genes could be potential targets for MetS. Similarly, 14 overlapping and 7 non-overlapping genes could be potential targets for inflammation. The CPV bioactives target genes were found to be involved in lipid and insulin homeostasis via several pathways revealed by the pathway analysis. The importance of CPV in treating MetS was supported by GO enrichment data; this could be due to its potential to influence pathways linked to metabolism, ER stress, mitochondrial dysfunction, oxidative stress, and inflammation. Conclusions: These results offer a promising approach to developing treatment and repurposing CPV for complex conditions such as MetS.
C1 [Dongre, Prashant; Majumdar, Anuradha] Bombay Coll Pharm, Dept Pharmacol, Mumbai 400098, India.
RP Majumdar, A (corresponding author), Bombay Coll Pharm, Dept Pharmacol, Mumbai 400098, India.
EM anuradha.majumdar@gmail.com
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NR 110
TC 0
Z9 0
U1 1
U2 2
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0975-9476
EI 0976-2809
J9 J AYURVEDA INTEGR ME
JI J. Ayurveda Integr. Med.
PD MAY-JUN
PY 2024
VL 15
IS 3
AR 100902
DI 10.1016/j.jaim.2024.100902
EA MAY 2024
PG 13
WC Integrative & Complementary Medicine
WE Emerging Sources Citation Index (ESCI)
SC Integrative & Complementary Medicine
GA UK5J3
UT WOS:001247962500001
PM 38821011
OA gold
DA 2025-06-11
ER

PT J
AU García-García, FJ
   Monistrol-Mula, A
   Cardellach, F
   Garrabou, G
AF Josep Garcia-Garcia, Francesc
   Monistrol-Mula, Anna
   Cardellach, Francesc
   Garrabou, Gloria
TI Nutrition, Bioenergetics, and Metabolic Syndrome
SO NUTRIENTS
LA English
DT Review
DE mitochondria; metabolic syndrome; mitochondrial dysfunction; balanced
   diet; nutrients; lifestyle
ID POLYUNSATURATED FATTY-ACIDS; IMPROVES INSULIN SENSITIVITY;
   CARDIOVASCULAR RISK-FACTORS; SKELETAL-MUSCLE CELLS; AGED GARLIC EXTRACT;
   VIRGIN OLIVE OIL; OXIDATIVE STRESS; KETOGENIC DIET; MITOCHONDRIAL
   DYSFUNCTION; BLOOD-PRESSURE
AB According to the World Health Organization (WHO), the global nutrition report shows that whilst part of the world's population starves, the other part suffers from obesity and associated complications. A balanced diet counterparts these extreme conditions with the proper proportion, composition, quantity, and presence of macronutrients, micronutrients, and bioactive compounds. However, little is known on the way these components exert any influence on our health. These nutrients aiming to feed our bodies, our tissues, and our cells, first need to reach mitochondria, where they are decomposed into CO2 and H2O to obtain energy. Mitochondria are the powerhouse of the cell and mainly responsible for nutrients metabolism, but they are also the main source of oxidative stress and cell death by apoptosis. Unappropriated nutrients may support mitochondrial to become the Trojan horse in the cell. This review aims to provide an approach to the role that some nutrients exert on mitochondria as a major contributor to high prevalent Western conditions including metabolic syndrome (MetS), a constellation of pathologic conditions which promotes type II diabetes and cardiovascular risk. Clinical and experimental data extracted from in vitro animal and cell models further demonstrated in patients, support the idea that a balanced diet, in a healthy lifestyle context, promotes proper bioenergetic and mitochondrial function, becoming the best medicine to prevent the onset and progression of MetS. Any advance in the prevention and management of these prevalent complications help to face these challenging global health problems, by ameliorating the quality of life of patients and reducing the associated sociosanitary burden.
C1 [Josep Garcia-Garcia, Francesc; Monistrol-Mula, Anna; Cardellach, Francesc; Garrabou, Gloria] Univ Barcelona, Hosp Clin Barcelona, Muscle Res & Mitochondrial Funct Lab, Internal Med Dept,Fac Med,CELLEX IDIBAPS, Barcelona 08036, Spain.
   [Josep Garcia-Garcia, Francesc; Monistrol-Mula, Anna; Cardellach, Francesc; Garrabou, Gloria] CIBERER Ctr Biomed Res Network Rare Dis, Madrid 28029, Spain.
C3 University of Barcelona; Hospital Clinic de Barcelona; IDIBAPS; CIBER -
   Centro de Investigacion Biomedica en Red; CIBERER
RP Garrabou, G (corresponding author), Univ Barcelona, Hosp Clin Barcelona, Muscle Res & Mitochondrial Funct Lab, Internal Med Dept,Fac Med,CELLEX IDIBAPS, Barcelona 08036, Spain.; Garrabou, G (corresponding author), CIBERER Ctr Biomed Res Network Rare Dis, Madrid 28029, Spain.
EM fjgarcia@ub.edu; annamoni95@gmail.com; fcardell@clinic.cat;
   garrabou@clinic.cat
RI Monistrol-Mula, Anna/GPX-5402-2022
OI Monistrol Mula, Anna/0000-0001-5879-3558; Garrabou,
   Gloria/0000-0001-8973-9933; Garcia Garcia, Francesc
   Josep/0000-0001-9021-0324; Cardellach, Francesc/0000-0003-3286-3436
FU Fondo de Investigaciones Sanitarias of the Instituto de Salud Carlos III
   (ISCIII) [PI1800498, PI1800451]; Centro de Investigacion Biomedica en
   Red de Enfermedades Raras (CIBERER), all initiatives of ISCIII; FEDER
   (`Una manera de hacer Europa'); Fundacio Privada Cellex; Suports a Grups
   de Recerca [2017 SGR 893]; CERCA programs from the Generalitat de
   Catalunya
FX The funders had no role in the study design, data collection and
   interpretation, or the decision to submit the work for publication, but
   contributed to support staff and material resources. This work was
   supported by funds from the Fondo de Investigaciones Sanitarias of the
   Instituto de Salud Carlos III (ISCIII) (grant numbers PI1800498 and
   PI1800451), the Centro de Investigacion Biomedica en Red de Enfermedades
   Raras (CIBERER), all initiatives of ISCIII and FEDER (`Una manera de
   hacer Europa'), as well as Fundacio Privada Cellex and Suports a Grups
   de Recerca (grant code 2017 SGR 893) and CERCA programs from the
   Generalitat de Catalunya.
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NR 329
TC 33
Z9 38
U1 0
U2 14
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD SEP
PY 2020
VL 12
IS 9
AR 2785
DI 10.3390/nu12092785
PG 38
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA OF6UL
UT WOS:000581339900001
PM 32933003
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Wei, J
   Sun, X
   Chen, YJ
   Li, YY
   Song, LQ
   Zhou, Z
   Xu, B
   Lin, Y
   Xu, SQ
AF Wei, Jie
   Sun, Xia
   Chen, Yajie
   Li, Yuanyuan
   Song, Liqiong
   Zhou, Zhao
   Xu, Bing
   Lin, Yi
   Xu, Shunqing
TI Perinatal exposure to bisphenol A exacerbates nonalcoholic
   steatohepatitis-like phenotype in male rat offspring fed on a high-fat
   diet
SO JOURNAL OF ENDOCRINOLOGY
LA English
DT Article
DE bisphenol A; steatosis; insulin resistance; oxidative stress;
   inflammation; fibrosis
ID HOMEOSTASIS MODEL ASSESSMENT; TYPE-2 DIABETES-MELLITUS; LIVER-DISEASE;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; GENE-EXPRESSION; MOUSE-LIVER;
   PPAR-ALPHA; MICE; SENSITIVITY
AB Bisphenol A (BPA) is one of the environmental endocrine disrupting chemicals, which is present ubiquitously in daily life. Accumulating evidence indicates that exposure to BPA contributes to metabolic syndrome. In this study, we examined whether perinatal exposure to BPA predisposed offspring to fatty liver disease: the hepatic manifestation of metabolic syndrome. Wistar rats were exposed to 50 mu g/kg per day BPA or corn oil throughout gestation and lactation by oral gavage. Offspring were fed a standard chow diet (SD) or a high-fat diet (HFD) after weaning. Effects of BPA were assessed by examination of hepatic morphology, biochemical analysis, and the hepatic expression of genes and/or proteins involved in lipogenesis, fatty acid oxidation, gluconeogenesis, insulin signaling, inflammation, and fibrosis. On a SD, the offspring of rats exposed to BPA exhibited moderate hepatic steatosis and altered expression of insulin signaling elements in the liver, but with normal liver function. On a HFD, the offspring of rats exposed to BPA showed a nonalcoholic steatohepatitis-like phenotype, characterized by extensive accumulation of lipids, large lipid droplets, profound ballooning degeneration, impaired liver function, increased inflammation, and even mild fibrosis in the liver. Perinatal exposure to BPA worsened the hepatic damage caused by the HFD in the rat offspring. The additive effects of BPA correlated with higher levels of hepatic oxidative stress. Collectively, exposure to BPA may be a new risk factor for the development of fatty liver disease and further studies should assess whether this finding is also relevant to the human population.
C1 [Li, Yuanyuan; Song, Liqiong; Zhou, Zhao; Xu, Bing; Xu, Shunqing] Huazhong Univ Sci & Technol, Sch Publ Hlth, Tongji Med Coll, Minist Educ,Key Lab Environm & Hlth, Wuhan 430030, Peoples R China.
   [Li, Yuanyuan; Song, Liqiong; Zhou, Zhao; Xu, Bing; Xu, Shunqing] Huazhong Univ Sci & Technol, Sch Publ Hlth, Tongji Med Coll, Minist Environm Protect, Wuhan 430030, Peoples R China.
   [Li, Yuanyuan; Song, Liqiong; Zhou, Zhao; Xu, Bing; Xu, Shunqing] Huazhong Univ Sci & Technol, Sch Publ Hlth, Tongji Med Coll, State Key Lab Environm Hlth Incubating, Wuhan 430030, Peoples R China.
   [Sun, Xia; Chen, Yajie; Lin, Yi] Chinese Acad Sci, Inst Urban Environm, Dept Environm & Mol Toxicol, Key Lab Urban Environm & Hlth, Xiamen 361021, Peoples R China.
   [Wei, Jie] Xiamen Univ, Coll Med, Dept Basic Med Sci, Xiamen 361102, Peoples R China.
C3 Ministry of Education - China; Huazhong University of Science &
   Technology; Huazhong University of Science & Technology; Huazhong
   University of Science & Technology; Chinese Academy of Sciences;
   Institute of Urban Environment, CAS; Xiamen University
RP Xu, SQ (corresponding author), Huazhong Univ Sci & Technol, Sch Publ Hlth, Tongji Med Coll, Minist Educ,Key Lab Environm & Hlth, Wuhan 430030, Peoples R China.
EM ylin@iue.ac.cn; xust@hust.edu.cn
RI chen, yundai/I-4353-2019; œSun, Xia/F-9084-2018; Li,
   Yuanyuan/GRS-1755-2022
OI Li, Yuanyuan/0000-0003-4967-3890; Xu, Shunqing/0000-0002-7771-3821; Sun,
   Xia/0000-0001-7733-9502; Chen, Yajie/0000-0001-6567-0396
FU National Program on Key Basic Research Project of China (973 Program)
   [2012CB722401]; National Natural Science Foundation of China [81030051,
   21177046, 21207128]; R&D Special Fund for Public Welfare Industry
   (Environment) [201309048]; National Basic Research Development Program
   of China [2008CB418206]; Fundamental Research Funds for the Central
   Universities, Huazhong University of Science and Technology [2012QN240,
   2012TS072]; Natural Science Foundation of Fujian Province, China
   [2013J05033]
FX This work was supported by the National Program on Key Basic Research
   Project of China (973 Program) (2012CB722401), the National Natural
   Science Foundation of China (81030051, 21177046, and 21207128), the R&D
   Special Fund for Public Welfare Industry (Environment) (201309048), the
   National Basic Research Development Program of China (2008CB418206), the
   Fundamental Research Funds for the Central Universities, Huazhong
   University of Science and Technology (2012QN240 and 2012TS072), and the
   Natural Science Foundation of Fujian Province, China (2013J05033).
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NR 45
TC 91
Z9 98
U1 3
U2 43
PU BIOSCIENTIFICA LTD
PI BRISTOL
PA EURO HOUSE, 22 APEX COURT WOODLANDS, BRADLEY STOKE, BRISTOL BS32 4JT,
   ENGLAND
SN 0022-0795
EI 1479-6805
J9 J ENDOCRINOL
JI J. Endocrinol.
PD SEP
PY 2014
VL 222
IS 3
BP 313
EP 325
DI 10.1530/JOE-14-0356
PG 13
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA AP2CW
UT WOS:000341881100008
PM 25112833
OA Bronze
DA 2025-06-11
ER

PT J
AU Ibrahim, MA
   Amin, EF
   Ibrahim, SA
   Abdelzaher, WY
   Abdelrahman, AM
AF Ibrahim, Mohamed A.
   Amin, Entesar F.
   Ibrahim, Salwa A.
   Abdelzaher, Walaa Y.
   Abdelrahman, Aly M.
TI Montelukast and irbesartan ameliorate metabolic and hepatic disorders in
   fructose-induced metabolic syndrome in rats
SO EUROPEAN JOURNAL OF PHARMACOLOGY
LA English
DT Article
DE Fructose-induced metabolic syndrome; Montelukast; Irbesartan
ID INSULIN-RESISTANCE; DEFENSE SYSTEM; LIVER; ANTAGONIST; THERAPY; DISEASE;
   OBESITY; DAMAGE; MODEL
AB Metabolic syndrome (MetS) is a global health problem Elucidation of the role of 5- lipooxygenase/leukotriene pathway and renin angiotensin system in the pathogenesis of MetS suggests a variety of potential therapies worthy of testing. The present work investigated the effect of montelukast, a leukotriene antagonist and/or irbesartan, an angiotensin II-receptor blocker, in the prevention of fructose induced MetS in rats. Rats were allocated into 9 groups and treated for 6 weeks as follow: normal control; MetS group (received 20% fructose); MetS + montelukast groups (treated with montelukast, 5, 10, and 20 mg/kg/day, respectively); MetS + irbesartan groups (treated withirbesartan 15, 30, and 45 mg/kg/day, respectively); and MetS + montelukast + irbesartan group (co treated with montelukast 5 mg/kg plus irbesartan 15 mg/g). Metabolic parameters (visceral fat index, liver index, insulin resistance, and serum lipid profile), oxidative stress markers (malondialdehyde, reduced glutathione, and catalase), and inflammatory mediators (tumor necrosis factor-alpha, and uric acid) were measured. Expression of caspase-3 in hepatic tissues was detected by immunohistochemistry. Liver injury was evaluated by histopathological examination and serum alanine aminotransferase (ALT). Montelukast, irbesartan, and their combination caused significant attenuation in metabolic and hepatic disorders. Their effect was associated with attenuation of oxidative stress markers, inflammatory mediators, and caspase-3 expression. This study highlighted the protective effects of montelukast and irbesartan against fructose-induced metabolic and hepatic disorders. The protective effect of either drug relics, at least in part, on their antioxidant and antiinflammatory effect, as well as on the reduction of caspase-3 expression in hepatic tissue. (C) 2013 Elsevier B.V. All rights reserved
C1 [Ibrahim, Mohamed A.; Amin, Entesar F.; Ibrahim, Salwa A.; Abdelzaher, Walaa Y.; Abdelrahman, Aly M.] Menia Univ, Fac Med, Dept Pharmacol, El Minia, Egypt.
C3 Egyptian Knowledge Bank (EKB); Minia University
RP Ibrahim, MA (corresponding author), Menia Univ, Fac Med, Dept Pharmacol, El Minia, Egypt.
EM maim69@yahoo.com
RI Abdelzaher, Walaa/W-1092-2019
OI Ibrahim, Mohamed/0000-0002-3203-944X; Afify, Entesar/0000-0003-2963-5555
CR Anjaneyulu M, 2004, AM J NEPHROL, V24, P488, DOI 10.1159/000080722
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NR 29
TC 27
Z9 29
U1 0
U2 11
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0014-2999
EI 1879-0712
J9 EUR J PHARMACOL
JI Eur. J. Pharmacol.
PD FEB 5
PY 2014
VL 724
BP 204
EP 210
DI 10.1016/j.ejphar.2013.12.024
PG 7
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA AA5LM
UT WOS:000331140500025
PM 24370493
DA 2025-06-11
ER

PT J
AU Lankinen, M
   Schwab, U
   Gopalacharyulu, PV
   Seppänen-Laakso, T
   Yetukuri, L
   Sysi-Aho, M
   Kallio, P
   Suortti, T
   Laaksonen, DE
   Gylling, H
   Poutanen, K
   Kolehmainen, M
   Oresic, M
AF Lankinen, M.
   Schwab, U.
   Gopalacharyulu, P. V.
   Seppanen-Laakso, T.
   Yetukuri, L.
   Sysi-Aho, M.
   Kallio, P.
   Suortti, T.
   Laaksonen, D. E.
   Gylling, H.
   Poutanen, K.
   Kolehmainen, M.
   Oresic, M.
TI Dietary carbohydrate modification alters serum metabolic profiles in
   individuals with the metabolic syndrome
SO NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
LA English
DT Article
DE Metabolic syndrome; Diet; Metabolomics; Lipidomics
ID WHOLE-GRAIN; CARDIOVASCULAR-DISEASE; INSULIN SENSITIVITY;
   LIPID-PEROXIDATION; GENE-EXPRESSION; ADIPOSE-TISSUE; INFLAMMATION;
   MARKERS; FIBER; SECRETION
AB Background and aims: Whole-grain cereals and diets with a low glycemic index may protect against the development of type 2 diabetes and heart disease, but the mechanisms are poorly understood. We studied the effect of carbohydrate modification on serum metabolic profiles, including lipids and branched chain amino acids, and dependencies between these and specific gene expression pathways in adipose tissue.
   Methods and results: Twenty subjects with metabolic syndrome were selected from the larger FUNGENUT study population, randomized either to a diet high in oat and wheat bread and potato (OWP) or rye bread and pasta (RP). Serum metabolomics analyses were performed using ultra-performance liquid chromatography coupled to electrospray ionization mass spectrometry (UPLC/MS), gas chromatography (GC) and UPLC.
   In the OWP group multiple proinflammatory lysophosphatidylcholines increased, while in the RP group docosahexaenoic acid (DHA 22:6n-3) increased and isoleucine decreased. mRNA expression of stress reactions- and adipose tissue differentiation-related genes were up-regulated in adipose tissue in the OWP group. In the RP group, however, pathways related to stress reactions and insulin signaling and energy metabolism were down-regulated. The lipid profiles had the strongest association with the changes in the adipose tissue differentiation pathway when using the elastic net regression model of the lipidomic profiles on selected pathways. Conclusion: Our results suggest that the dietary carbohydrate modification alters the serum metabolic profile, especially in lysoPC species, and may, thus, contribute to proinflammatory processes which in turn promote adverse changes in insulin and glucose metabolism. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Lankinen, M.; Schwab, U.; Gylling, H.] Univ Kuopio, Dept Clin Nutr, Sch Publ Hlth & Clin Nutr, FI-70211 Kuopio, Finland.
   [Lankinen, M.; Gopalacharyulu, P. V.; Seppanen-Laakso, T.; Yetukuri, L.; Sysi-Aho, M.; Suortti, T.; Poutanen, K.; Oresic, M.] VTT Tech Res Ctr Finland, Espoo, Finland.
   [Schwab, U.; Laaksonen, D. E.; Gylling, H.] Kuopio Univ Hosp, Inst Clin Med, SF-70210 Kuopio, Finland.
   [Kallio, P.; Poutanen, K.; Kolehmainen, M.] Univ Kuopio, Sch Publ Hlth & Clin Nutr, Food & Hlth Res Ctr, Dept Clin Nutr, FI-70211 Kuopio, Finland.
   [Laaksonen, D. E.] Univ Kuopio, Inst Biomed, FI-70211 Kuopio, Finland.
C3 University of Eastern Finland; VTT Technical Research Center Finland;
   University of Eastern Finland; University of Eastern Finland Hospital;
   Kuopio University Hospital; University of Eastern Finland; University of
   Eastern Finland
RP Lankinen, M (corresponding author), Univ Kuopio, Dept Clin Nutr, Sch Publ Hlth & Clin Nutr, POB 1627, FI-70211 Kuopio, Finland.
EM Maria.Lankinen@uku.fi
RI Kolehmainen, Marjukka/JFS-1563-2023; Oresic, Matej/K-7673-2016;
   Peddinti, Gopal/G-4872-2016
OI Lankinen, Maria/0000-0002-9158-283X; Oresic, Matej/0000-0002-2856-9165;
   Peddinti, Gopal/0000-0002-8767-968X; Kolehmainen,
   Marjukka/0000-0002-3770-2538
FU Fazer bakeries Ltd; Vaasan Et Vaasan oy; Technology Development Center
   of Finland; Academy of Finland [117996, 209445, 210449]; Sigrid Juselius
   Foundation; Academy of Finland (AKA) [210449, 209445, 117996] Funding
   Source: Academy of Finland (AKA)
FX Sources of Support for research: This work was supported by Fazer
   bakeries Ltd, Vaasan Et Vaasan oy, and the Technology Development Center
   of Finland and the Academy of Finland (no 117996 to MO, no 209445 to MK,
   no 210449 to HG), and the Sigrid Juselius Foundation.
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NR 34
TC 40
Z9 44
U1 0
U2 35
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0939-4753
EI 1590-3729
J9 NUTR METAB CARDIOVAS
JI Nutr. Metab. Carbiovasc. Dis.
PD MAY
PY 2010
VL 20
IS 4
BP 249
EP 257
DI 10.1016/j.numecd.2009.04.009
PG 9
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism; Nutrition
   & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism;
   Nutrition & Dietetics
GA 612IU
UT WOS:000278891900005
PM 19553094
DA 2025-06-11
ER

PT J
AU Hupa-Breier, KL
   Schenk, H
   Campos-Murguia, A
   Wellhöner, F
   Heidrich, B
   Dywicki, J
   Hartleben, B
   Böker, C
   Mall, J
   Terkamp, C
   Wilkens, L
   Becker, F
   Rudolph, KL
   Manns, MP
   Mederacke, YS
   Marhenke, S
   Redeker, H
   Lieber, M
   Iordanidis, K
   Taubert, R
   Wedemeyer, H
   Noyan, F
   Hardtke-Wolenski, M
   Jaeckel, E
AF Hupa-Breier, Katharina L.
   Schenk, Heiko
   Campos-Murguia, Alejandro
   Wellhoener, Freya
   Heidrich, Benjamin
   Dywicki, Janine
   Hartleben, Bjoern
   Boeker, Clara
   Mall, Julian
   Terkamp, Christoph
   Wilkens, Ludwig
   Becker, Friedrich
   Rudolph, Karl Lenhard
   Manns, Michael Peter
   Mederacke, Young-Seon
   Marhenke, Silke
   Redeker, Hanna
   Lieber, Maren
   Iordanidis, Konstantinos
   Taubert, Richard
   Wedemeyer, Heiner
   Noyan, Fatih
   Hardtke-Wolenski, Matthias
   Jaeckel, Elmar
TI Novel translational mouse models of metabolic dysfunction-associated
   steatotic liver disease comparable to human MASLD with severe obesity
SO MOLECULAR METABOLISM
LA English
DT Article
DE Metabolic dysfunction-associated steatotic liver disease; Metabolic
   syndrome; Mouse model; Kidney injury; Non-alcoholic fatty liver disease
ID NONALCOHOLIC FATTY LIVER; INSULIN SENSITIVITY; GUT MICROBIOME; KIDNEY
   INJURY; GENE; PATHOGENESIS; INFLAMMATION; CIRRHOSIS; SYSTEM; NAFLD
AB Objective: Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common cause of chronic liver disease, especially in patients with severe obesity. However, current mouse models for MASLD do not reflect the polygenetic background nor the metabolic changes in this population. Therefore, we investigated two novel mouse models of MASLD with a polygenetic background for the metabolic syndrome. Methods: TALLYHO/JngJ mice and NONcNZO10/LtJ mice were fed a high-fat- high-carbohydrate (HF-HC) diet with a surplus of cholesterol diet. A second group of TH mice was additional treated with empagliflozin. Results: After sixteen weeks of feeding, both strains developed metabolic syndrome with severe obesity and histological manifestation of steatohepatitis, which was associated with significantly increased intrahepatic CD8+cells, CD4+cells and Tregs, contributing to a significant increase in pro-inflammatory and pro-fibrotic gene activation as well as ER stress and oxidative stress. In comparison with the human transcriptomic signature, we could demonstrate a good metabolic similarity, especially for the TH mouse model. Furthermore, TH mice also developed signs of kidney injury as an extrahepatic comorbidity of MASLD. Additional treatment with empagliflozin in TH mice attenuates hepatic steatosis and improves histological manifestation of MASH. Conclusions: Overall, we have developed two promising new mouse models that are suitable for preclinical studies of MASLD as they recapitulate most of the key features of MASLD. (c) 2025 The Authors. Published by Elsevier GmbH. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
C1 [Hupa-Breier, Katharina L.; Campos-Murguia, Alejandro; Wellhoener, Freya; Heidrich, Benjamin; Dywicki, Janine; Terkamp, Christoph; Manns, Michael Peter; Mederacke, Young-Seon; Marhenke, Silke; Redeker, Hanna; Lieber, Maren; Iordanidis, Konstantinos; Taubert, Richard; Wedemeyer, Heiner; Noyan, Fatih; Hardtke-Wolenski, Matthias; Jaeckel, Elmar] Hannover Med Sch, Dept Gastroenterol Hepatol Infect Dis & Endocrinol, Carl Neuberg Str 1, D-30625 Hannover, Germany.
   [Schenk, Heiko] Hannover Med Sch, Dept Nephrol & Hypertens, Hannover, Germany.
   [Hartleben, Bjoern] Hannover Med Sch, Inst Pathol, Hannover, Germany.
   [Becker, Friedrich; Rudolph, Karl Lenhard] Leibniz Inst Aging, Fritz Lipmann Inst FLI, Res Grp Stem Cell & Metab Aging, D-07745 Jena, Germany.
   [Boeker, Clara; Mall, Julian] Klinikum Nordstadt, Dept Gen Visceral Vasc & Bariatr Surg, D-30167 Hannover, Germany.
   [Wilkens, Ludwig] Nordstadt Hosp Hannover, Dept Pathol, D-30167 Hannover, Germany.
   [Hardtke-Wolenski, Matthias] Univ Duisburg Essen, Univ Hosp Essen, Inst Med Microbiol, Essen, Germany.
   [Jaeckel, Elmar] Univ Toronto, United Hlth Network, Toronto Gen Hosp, Ajmera Transplant Ctr, Toronto, ON, Canada.
C3 Hannover Medical School; Hannover Medical School; Hannover Medical
   School; Leibniz Association; Leibniz Institut fur Alternsforschung -
   Fritz-Lipmann-Institut (FLI); University of Duisburg Essen; University
   of Toronto; University Health Network Toronto; Toronto General Hospital
RP Hupa-Breier, KL (corresponding author), Hannover Med Sch, Dept Gastroenterol Hepatol Infect Dis & Endocrinol, Carl Neuberg Str 1, D-30625 Hannover, Germany.
EM hupa.katharina@mh-hannover.de
RI Manns, Michael/AFG-3063-2022; Noyan, Fatih/B-9449-2018;
   Hardtke-Wolenski, Matthias/I-2993-2019
OI Hardtke-Wolenski, Matthias/0000-0002-2827-7787
FU Deutsche Forschungsgemeinschaft [SFB 738, SFB TR127]; HiLF program
   (Hochschulinterne Leistungsforderung) of Hannover Medical School;
   PRACTIS - Clinician Scientist Program of Hannover Medical School [ME
   3696/3-1]; German Research Foundation (DFG) [ME 3696/3-1]
FX The authors were supported by grants from the Deutsche
   Forschungsgemeinschaft (SFB 738, SFB TR127) as well as by the HiLF
   program (Hochschulinterne Leistungsforderung) of Hannover Medical
   School. Katharina Hupa-Breier and Heiko Schenk were supported by the
   PRACTIS - Clinician Scientist Program of Hannover Medical School, funded
   by the German Research Foundation (DFG, ME 3696/3-1). The funders had no
   influence on study design, data collection and analysis, decision to
   publish or preparation of the manuscript.
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NR 103
TC 0
Z9 0
U1 3
U2 3
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2212-8778
J9 MOL METAB
JI Mol. Metab.
PD MAR
PY 2025
VL 93
AR 102104
DI 10.1016/j.molmet.2025.102104
EA JAN 2025
PG 18
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA U9I4Z
UT WOS:001414839800001
PM 39855563
OA gold
DA 2025-06-11
ER

PT J
AU Tomassoni, D
   Nwankwo, IE
   Gabrielli, MG
   Bhatt, S
   Muhammad, AB
   Lokhandwala, MF
   Tayebati, SK
   Amenta, F
AF Tomassoni, Daniele
   Nwankwo, Innocent Ejike
   Gabrielli, Maria Gabriella
   Bhatt, Siddhartha
   Muhammad, Abdul Bari
   Lokhandwala, Mustafa F.
   Tayebati, Seyed Khosrow
   Amenta, Francesco
TI Astrogliosis in the brain of obese Zucker rat: A model of metabolic
   syndrome
SO NEUROSCIENCE LETTERS
LA English
DT Article
DE Metabolic syndrome; Obese Zucker rats; Brain; Astrogliosis
ID FIBRILLARY ACIDIC PROTEIN; SPONTANEOUSLY HYPERTENSIVE-RATS;
   ALZHEIMERS-DISEASE; OXIDATIVE STRESS; RISK-FACTORS; ASTROCYTES;
   DEMENTIA; GFAP; HIPPOCAMPUS; EXPRESSION
AB Metabolic syndrome (MetS) is a disorder characterized primarily by the development of insulin resistance. Insulin resistance and subsequent hyperinsulinemia, originating from abdominal obesity, increases the risk of cerebrovascular and cardiovascular disease and all-cause mortality. Obesity is probably a risk factor for Alzheimer's disease and vascular dementia and is associated with impaired cognitive function. The obese Zucker rat (OZR) represents a model of type 2 diabetes exhibiting a moderate degree of arterial hypertension and of increased oxidative stress. To clarify the possible relationships between MetS and brain damage, the present study has investigated brain microanatomy in OZRs compared with their littermate controls lean Zucker rats (LZRs). Male OZRs and LZRs of 12 weeks of age were used. Their brain was processed for immunochemical and immunohistochemical analysis of glial fibrillaiy acidic protein (GFAP). In frontal and parietal cortex of OZRs a significant increase in the number of GFAP immunoreactive astrocytes was observed. Similar findings were found in the hippocampus, where an increased number of GFAP immunoreactive astrocytes were detected in the CA1 and CA3 subfields and dentate gyrus of OZRs compared to the LZRs. These findings indicating the occurrence of brain injury accompanied by astrogliosis in OZRs suggest that these rats, developed as an animal model of type 2 diabetes, may also represent a model for assessing the influence of MetS on brain. The identification of neurodegenerative changes in OZRs may represent the first step for better characterizing neuronal involvement in this model of MetS and possible treatment for countering it. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
C1 [Tomassoni, Daniele; Gabrielli, Maria Gabriella] Univ Camerino, Sch Biosci & Biotechnol, I-62032 Camerino, MC, Italy.
   [Nwankwo, Innocent Ejike; Tayebati, Seyed Khosrow; Amenta, Francesco] Univ Camerino, Sch Med & Hlth Prod, I-62032 Camerino, Italy.
   [Bhatt, Siddhartha; Muhammad, Abdul Bari; Lokhandwala, Mustafa F.] Univ Houston, Coll Pharm, Heart & Kidney Inst, Houston, TX 77204 USA.
C3 University of Camerino; University of Camerino; University of Houston
   System; University of Houston
RP Tomassoni, D (corresponding author), Univ Camerino, Sch Biosci & Biotechnol, Via Gentile 3 Varano, I-62032 Camerino, MC, Italy.
EM daniele.tomassoni@unicam.it
RI Tayebati, Seyed/AGK-8739-2022
OI NWANKWO, EJIKE/0000-0002-1166-9709
CR de Artiñano AA, 2009, BRIT J NUTR, V102, P1246, DOI 10.1017/S0007114509990729
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NR 30
TC 48
Z9 53
U1 0
U2 11
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0304-3940
EI 1872-7972
J9 NEUROSCI LETT
JI Neurosci. Lett.
PD MAY 24
PY 2013
VL 543
BP 136
EP 141
DI 10.1016/j.neulet.2013.03.025
PG 6
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 154BH
UT WOS:000319646000027
PM 23545209
DA 2025-06-11
ER

PT J
AU Cat, AND
   Jaisser, F
AF Cat, Aurelie Nguyen Dinh
   Jaisser, Frederic
TI Extrarenal effects of aldosterone
SO CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION
LA English
DT Review
DE aldosterone; fibrogenic and proinflammatory effects; metabolic syndrome;
   mineralocorticoid receptor; receptor tyrosine kinases
ID VASCULAR SMOOTH-MUSCLE; PERIVASCULAR ADIPOSE-TISSUE; SPONTANEOUSLY
   HYPERTENSIVE-RATS; NITRIC-OXIDE SYNTHASE; MINERALOCORTICOID RECEPTOR
   EXPRESSION; INDUCED CARDIAC FIBROSIS; NF-KAPPA-B; ANGIOTENSIN-II;
   OXIDATIVE STRESS; INSULIN-RESISTANCE
AB Purpose of review
   The renal distal tubule has been considered for a long time as the main cellular target of aldosterone, where the hormone enhances sodium reabsorption and potassium secretion. However, other cell types in nonepithelial tissues, such as the heart, the vessels, adipose tissue, and macrophages, are now also recognized as targets for aldosterone. The functions that aldosterone exerts in these nonclassical target tissues are still a matter of debate. This review will highlight the recent findings on the extrarenal effects of aldosterone.
   Recent findings
   Numerous studies showed that aldosterone exerts profibrotic and proinflammatory effects, but one or more cofactors such as salt, angiotensin II, and oxidative stress are required. Moreover, inflammation and macrophage infiltration are a prerequisite to aldosterone-induced cardiac fibrosis. This underlines a key role for aldosterone and the mineralocorticoid receptor in macrophages. Inflammatory effects of aldosterone in vascular smooth muscle cells involve trafficking to lipid rafts/caveolae through receptor tyrosine kinases. Finally, a growing body of evidence indicates a prominent role of aldosterone/mineralocorticoid receptor in the metabolic syndrome, in insulin resistance, and in adipocyte biology.
   Summary
   The idiom from Socrates, 'the more we learn, the less we know', can be applied to aldosterone with its different facets and its pleiotropic effects. There is clear evidence for rapid nongenomic effects of aldosterone, mineralocorticoid receptor-dependent and mineralocorticoid receptor-independent signaling, in the heart, the vessels, and other nonepithelial tissues, leading to inflammation, fibrosis, and progression of cardiovascular diseases including hypertension and metabolic syndrome.
C1 [Cat, Aurelie Nguyen Dinh] Univ Ottawa, Kidney Res Ctr, Ottawa Hosp, Res Inst, Ottawa, ON K1H 8M5, Canada.
   [Jaisser, Frederic] Univ Paris 06, INSERM, Ctr Rech Cordeliers, UMR Team 1 872, Paris, France.
C3 University of Ottawa; Ottawa Hospital Research Institute; Sorbonne
   Universite; Universite Paris Cite; Institut National de la Sante et de
   la Recherche Medicale (Inserm)
RP Cat, AND (corresponding author), Univ Ottawa, Kidney Res Ctr, Ottawa Hosp, Res Inst, 451 Smyth Rd, Ottawa, ON K1H 8M5, Canada.
EM cattuong.ndc@gmail.com
RI CAT, Aurelie/H-8182-2013; Jaisser, Frederic/P-4287-2017
OI Jaisser, Frederic/0000-0001-9051-1901
FU Canadian Institute of Health Research (CIHR); INSERM; Leducq foundation;
   Transatlantic Network on Hypertension
FX A.N.D.C. is supported by the Canadian Institute of Health Research
   (CIHR). Grants from INSERM, the Leducq foundation and Transatlantic
   Network on Hypertension supported this work.
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NR 140
TC 85
Z9 85
U1 0
U2 13
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1062-4821
EI 1473-6543
J9 CURR OPIN NEPHROL HY
JI Curr. Opin. Nephrol. Hypertens.
PD MAR
PY 2012
VL 21
IS 2
BP 147
EP 156
DI 10.1097/MNH.0b013e32834fb25b
PG 10
WC Urology & Nephrology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology; Cardiovascular System & Cardiology
GA 894DC
UT WOS:000300406200006
PM 22240440
DA 2025-06-11
ER

PT J
AU Kobori, M
   Akimoto, Y
   Takahashi, Y
   Kimura, T
AF Kobori, Masuko
   Akimoto, Yukari
   Takahashi, Yumiko
   Kimura, Toshiyuki
TI Combined Effect of Quercetin and Fish Oil on Oxidative Stress in the
   Liver of Mice Fed a Western-Style Diet
SO JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
LA English
DT Article
DE quercetin; antioxidant; fish oil; DHA; Western diet; liver; epididymal
   adipose tissue
ID LIPID-PEROXIDATION PRODUCTS; FATTY-ACIDS; CARDIOVASCULAR-DISEASE;
   DOCOSAHEXAENOIC ACID; METABOLIC SYNDROME; ADIPOSE-TISSUE; RISK;
   UNSATURATION; PATHOGENESIS; INFLAMMATION
AB To study the combined effect of the flavonoid quercetin and fish oil containing co-3 fatty acids on preventing diet-induced metabolic syndrome, we fed mice with a control diet, a high-fat, high-sucrose, and high-cholesterol Western-style diet (Western diet), a Western diet supplemented with 0.05% quercetin, a Western diet containing 5% fish oil rich in docosahexaenoic acid (DHA) (DHA diet), or a DHA diet supplemented with 0.05% quercetin. After 18 weeks of feeding, fish oil potentiated the suppression of lipid peroxidation by quercetin in the liver but not in the epididymal adipose tissue. Fish oil but not quercetin suppressed the accumulation of non-esterified fatty acids and the expression of fatty acid synthase in the liver of Western-diet-fed mice. Thus, the combination of quercetin and DHA-rich fish oil may partly alleviate non-alcoholic fatty liver disease by reducing oxidative stress and suppressing fatty acid synthesis.
C1 [Kobori, Masuko; Akimoto, Yukari; Takahashi, Yumiko; Kimura, Toshiyuki] Natl Agr & Food Res Org, Food Res Inst, Tsukuba, Ibaraki 3058642, Japan.
C3 National Agriculture & Food Research Organization - Japan
RP Kobori, M (corresponding author), Natl Agr & Food Res Org, Food Res Inst, Tsukuba, Ibaraki 3058642, Japan.
EM kobori@affrc.go.jp
FU Skylark Food Science Institute; Project of the NARO Bio-oriented
   Technology Research Advancement Institution R&D matching funds on the
   Field for Knowledge Integration and Innovation
FX This work was financially supported in part by grants from the Skylark
   Food Science Institute (to Masuko Kobori) and the Project of the NARO
   Bio-oriented Technology Research Advancement Institution R&D matching
   funds on the Field for Knowledge Integration and Innovation.
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NR 41
TC 10
Z9 10
U1 0
U2 35
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0021-8561
EI 1520-5118
J9 J AGR FOOD CHEM
JI J. Agric. Food Chem.
PD NOV 18
PY 2020
VL 68
IS 46
BP 13267
EP 13275
DI 10.1021/acs.jafc.0c02984
PG 9
WC Agriculture, Multidisciplinary; Chemistry, Applied; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture; Chemistry; Food Science & Technology
GA OW5JM
UT WOS:000592922700053
PM 32786869
DA 2025-06-11
ER

PT J
AU Wan, MX
   Li, Q
   Lei, QY
   Zhou, D
   Wang, S
AF Wan, Meixia
   Li, Qing
   Lei, Qianya
   Zhou, Dan
   Wang, Shu
TI Polyphenols and Polysaccharides from Morus alba L. Fruit
   Attenuate High-Fat Diet-Induced Metabolic Syndrome Modifying the Gut
   Microbiota and Metabolite Profile
SO FOODS
LA English
DT Article
DE Morus alba L. fruit; polyphenols; polysaccharides; metabolic syndrome;
   gut microbiota; untargeted fecal metabolomics
ID INTESTINAL MICROBIOTA; OXIDATIVE STRESS; KIDNEY-DISEASE; MULBERRY;
   ACTIVATION; INFLAMMATION; DYSBIOSIS; NAFLD
AB Morus alba L. fruit, a medicinal and edible fruit in East Asia, showed potential health-promoting effects against metabolic syndrome (MetS). However, both the protective effects and mechanisms of different fractions extracted from Morus alba L. fruit against MetS remain unclear. Additionally, the gut microbiota and its metabolites are regarded as key factors in the development of MetS. This study aimed to investigate the potential role of polyphenols and polysaccharides derived from Morus alba L. fruit against MetS in high-fat diet (HFD)-fed mice, individually and in combination, focusing on remodeling effects on gut microbiota and metabolite profiles. In the study, polyphenols and polysaccharides derived from Morus alba L. fruit improved the traditional pharmacodynamic parameters of MetS, including reductions in body weight (BW) and fat accumulation, improvement in insulin resistance, regulation of dyslipidemia, prevention of pathological changes in liver, kidney and proximal colon tissue, and suppressive actions against oxidative stress. In particular, the group treated with polyphenols and polysaccharides in combination showed better efficacy. The relative abundance of beneficial bacterial genera Muribaculum and Lachnospiraceae_NK4A136_group were increased to various degrees, while opportunistic pathogens such as Prevotella_2, Bacteroides, Faecalibacterium and Fusobacterium were markedly decreased after treatments. Moreover, fecal metabolite profiles revealed 23 differential metabolites related to treatments with polyphenols and polysaccharides derived from Morus alba L. fruit, individually and in combination. Altogether, these results demonstrated that polyphenols and polysaccharides derived from Morus alba L. fruit attenuated MetS in HFD-fed mice, and improved the gut microbiota composition and fecal metabolite profiles.
C1 [Wan, Meixia; Li, Qing; Lei, Qianya; Zhou, Dan; Wang, Shu] Sichuan Univ, West China Sch Pharm, Chengdu 610041, Peoples R China.
   [Wan, Meixia] Longdong Univ, Qibo Coll Med, Qingyang 745000, Peoples R China.
C3 Sichuan University; Longdong University
RP Wang, S (corresponding author), Sichuan Univ, West China Sch Pharm, Chengdu 610041, Peoples R China.
EM wanmeixia2010@126.com; 18381476874@163.com; lqy2205@126.com;
   wendyzz12@163.com; wang_shu@scu.edu.cn
RI Li, Qing/GZM-3164-2022
FU Sichuan Science and Technology Program [2020YFS0031]; Longdong
   University [XYZK1606]
FX This research was funded by Sichuan Science and Technology Program,
   grant number 2020YFS0031, and Longdong University, grant number
   XYZK1606.
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NR 68
TC 14
Z9 14
U1 8
U2 74
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2304-8158
J9 FOODS
JI Foods
PD JUN
PY 2022
VL 11
IS 12
AR 1818
DI 10.3390/foods11121818
PG 20
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA 2K8ZB
UT WOS:000816616200001
PM 35742014
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Portincasa, P
   Krawczyk, M
   Smyk, W
   Lammert, F
   Di Ciaula, A
AF Portincasa, Piero
   Krawczyk, Marcin
   Smyk, Wiktor
   Lammert, Frank
   Di Ciaula, Agostino
TI COVID-19 and non-alcoholic fatty liver disease: Two intersecting
   pandemics
SO EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
LA English
DT Review
DE fatty liver; mitochondria; nitrosative stress; oxidative stress;
   SARS-CoV-2
ID METABOLIC SYNDROME; CLINICAL CHARACTERISTICS; FUNCTIONAL RECEPTOR;
   CARDIOVASCULAR RISK; INSULIN-RESISTANCE; LIFE-STYLE; OBESITY;
   CORONAVIRUS; INFLAMMATION; INJURY
AB Background Initial evidence from China suggests that most vulnerable subjects to COVID-19 infection suffer from pre-existing illness, including metabolic abnormalities. The pandemic characteristics and high-lethality rate of COVID-19 infection have raised concerns about interactions between virus pathobiology and components of the metabolic syndrome. Methods We harmonized the information from the recent existing literature on COVID-19 acute pandemic and mechanisms of damage in non-alcoholic fatty liver disease (NAFLD), as an example of chronic (non-communicable) metabolic pandemic. Results COVID-19-infected patients are more fragile with underlying metabolic illness, including hypertension, cardiovascular disease, type 2 diabetes, chronic lung diseases (e.g. asthma, chronic obstructive pulmonary disease and emphysema) and metabolic syndrome. During metabolic abnormalities, expansion of metabolically active fat ('overfat condition') parallels chronic inflammatory changes, development of insulin resistance and accumulation of fat in configuring NAFLD. The deleterious interplay of inflammatory pathways chronically active in NAFLD and acutely in COVID-19-infected patients, can explain liver damage in a subgroup of patients and might condition a worse outcome in metabolically compromised NAFLD patients. In a subgroup of patients with NAFLD, the underlying liver fibrosis might represent an additional and independent risk factor for severe COVID-19 illness, irrespective of metabolic comorbidities. Conclusions NAFLD can play a role in the outcome of COVID-19 illness due to frequent association with comorbidities. Initial evidences suggest that increased liver fibrosis in NAFLD might affect COVID-19 outcome. In addition, long-term monitoring of post-COVID-19 NAFLD patients is advisable, to document further deterioration of liver damage. Further studies are required in this field.
C1 [Portincasa, Piero; Di Ciaula, Agostino] Univ Bari Aldo Moro, Dept Biomed Sci & Human Oncol, Clin Med A Murri, Bari, Italy.
   [Krawczyk, Marcin; Lammert, Frank] Saarland Univ, Med Ctr, Dept Med 2, Homburg, Germany.
   [Krawczyk, Marcin] Med Univ Warsaw, Ctr Preclin Res, Dept Gen Transplant & Liver Surg, Lab Metab Liver Dis, Warsaw, Poland.
   [Smyk, Wiktor] Med Univ Warsaw, Dept Gen Transplant & Liver Surg, Liver & Internal Med Unit, Warsaw, Poland.
C3 Universita degli Studi di Bari Aldo Moro; Universitatsklinikum des
   Saarlandes; Medical University of Warsaw; Medical University of Warsaw
RP Portincasa, P (corresponding author), Univ Aldo Moro, Dept Biomed Sci & Human Oncol, Clin Med A Murri, Med Sch,Policlin Hosp, Piazza G Cesare 11, I-70124 Bari, Italy.
EM piero.portincasa@uniba.it
RI Krawczyk, Marcin/AAG-4356-2020; portincasa, piero/J-7245-2018; Di
   Ciaula, Agostino/AAW-3499-2021; Di Ciaula, Agostino/M-4300-2017
OI Di Ciaula, Agostino/0000-0002-5476-7376; Krawczyk,
   Marcin/0000-0002-0113-0777; portincasa, piero/0000-0001-5359-1471
FU European Union's Horizon 2020 Research and Innovation framework, under
   the Marie SklodowskaCurie Grant Agreement [734719, 722619]
FX The present paper originates in the context of the projects FOIE GRAS
   (#722619) and mtFOIE GRAS (#734719), which have received funding from
   the European Union's Horizon 2020 Research and Innovation framework,
   under the Marie SklodowskaCurie Grant Agreement.
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NR 115
TC 92
Z9 96
U1 0
U2 9
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0014-2972
EI 1365-2362
J9 EUR J CLIN INVEST
JI Eur. J. Clin. Invest.
PD OCT
PY 2020
VL 50
IS 10
AR e13338
DI 10.1111/eci.13338
EA AUG 2020
PG 10
WC Medicine, General & Internal; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Research & Experimental Medicine
GA NW6XF
UT WOS:000562462900001
PM 32589264
OA Green Published
DA 2025-06-11
ER

PT J
AU Boskovic, M
   Bundalo, M
   Zivkovic, M
   Stanisic, J
   Kostic, M
   Koricanac, G
   Stankovic, A
AF Boskovic, Maja
   Bundalo, Maja
   Zivkovic, Maja
   Stanisic, Jelena
   Kostic, Milan
   Koricanac, Goran
   Stankovic, Aleksandra
TI Estradiol ameliorates antioxidant axis SIRT1-FoxO3a-MnSOD/catalase in
   the heart of fructose-fed ovariectomized rats
SO JOURNAL OF FUNCTIONAL FOODS
LA English
DT Article
DE Metabolic syndrome; Fructose; Estradiol; Heart; miRNA
ID ACTIVATED PROTEIN-KINASE; NADPH OXIDASE ACTIVATION; ENERGY SENSING
   NETWORK; OXIDATIVE STRESS; INSULIN-RESISTANCE; VASCULAR DYSFUNCTION;
   FEMALE RATS; RICH DIET; SIRT1; AMPK
AB Harmful effects of fructose-rich diet (FRD) were predominantly observed in males, suggesting protective effects of estrogens. Little is known about AMPK/sirtuin-1 (SIRT1)/forkhead box O3 (FoxO3a)/manganese superoxide dismutase (MnSOD)/catalase signaling in the heart in state of metabolic syndrome and oxidative stress induced by fructose over-consumption. We investigated the effect of 10% FRD on expression of AMPK-SIRT1-FoxO3a-MnSOD/catalase axis in myocardium and potentially beneficial effect of 17 beta-estradiol replacement. The expression of NADPH oxidase 4 (Nox4) and miRNA-155, unfavorable regulators of this axis, were also investigated. FRD significantly increased AMPK and decreased FoxO3a activity, decreased SIRT1, MnSOD and Nox4 protein expression while E2 reverted these changes, except for Nox4, and increased catalase protein level. E2 diminished Nox4 and MnSOD mRNA level in FRD ovariectomized rats. These results suggest independent response of AMPK and SIRT to FRD treatment. The proposed signaling in the heart should be further investigated in the prooxidative and antioxidative milieu.
C1 [Boskovic, Maja; Bundalo, Maja; Zivkovic, Maja; Stankovic, Aleksandra] Univ Belgrade, Vinca Inst Nucl Sci, Lab Radiobiol & Mol Genet, Belgrade, Serbia.
   [Stanisic, Jelena; Kostic, Milan; Koricanac, Goran] Univ Belgrade, Vinca Inst Nucl Sci, Lab Mol Biol & Endocrinol, Belgrade, Serbia.
   [Bundalo, Maja] Univ Hosp Wurzburg, Inst Expt Biomed, Wurzburg, Germany.
C3 University of Belgrade; University of Belgrade; University of Wurzburg
RP Stankovic, A (corresponding author), Vinca Inst Nucl Sci, Lab Radiobiol & Mol Genet, POB 522, Belgrade 11000, Serbia.
EM alexas@vinca.rs
RI Korićanac, Goran/ABF-6544-2021; Stankovic, Aleksandra/T-1064-2018;
   Kostic, Milan/IUM-1526-2023; Zivkovic, Maja/T-1038-2018
OI Zivkovic, Maja/0000-0002-0447-6626; Kostic, Milan/0000-0003-4680-5835;
   Boskovic, Maja/0000-0003-0167-2522; Jakovljevic,
   Jelena/0000-0002-4365-9169; Koricanac, Goran/0000-0002-9852-3330
FU Ministry of Education, Science and Technological Development of the
   Republic of Serbia [OI175085, III 41009]
FX This work was supported by The Ministry of Education, Science and
   Technological Development of the Republic of Serbia (grant numbers
   OI175085, III 41009).
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NR 70
TC 7
Z9 8
U1 0
U2 26
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1756-4646
J9 J FUNCT FOODS
JI J. Funct. Food.
PD JAN
PY 2019
VL 52
BP 690
EP 698
DI 10.1016/j.jff.2018.11.053
PG 9
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA HH4KR
UT WOS:000455691800073
DA 2025-06-11
ER

PT J
AU Nour, OA
   Ghoniem, HA
   Nader, MA
   Suddek, GM
AF Nour, Omnia A.
   Ghoniem, Hamdy A.
   Nader, Manar A.
   Suddek, Ghada M.
TI Impact of protocatechuic acid on high fat diet-induced metabolic
   syndrome sequelae in rats
SO EUROPEAN JOURNAL OF PHARMACOLOGY
LA English
DT Article
DE High fat diet; Metabolic syndrome; Protocatechuic acid; Adiponectin;
   pAkt; Free fatty acids; IL-1b
ID ADIPOSE-TISSUE DYSFUNCTION; OXIDATIVE STRESS; INSULIN-RESISTANCE;
   ESTABLISHED ATHEROSCLEROSIS; ENDOTHELIAL DYSFUNCTION; RISK-FACTORS;
   BETA-CELL; OBESITY; ADIPONECTIN; GLUCOSE
AB The study aimed to assess the possible protective impact of protocatechuic acid (PCA) on high fat diet (HFD)induced metabolic syndrome (Mets) sequelae in rats. Forty-two male Sprague-Dawley (SD) rats were randomly grouped as follows: CTR group; PCA group; HFD group; HFD-PCA group and HFD-MET group. Rats were fed on standard diet or HFD for 14 weeks. HFD-fed rats exhibited significant decreases in food intake and adiponectin (ADP) level; yet, body weight and anthropometrical parameters were significantly increased. Moreover, insulin sensitivity was impaired as indicated by significant elevation in glucose AUC during oral glucose tolerance test (OGTT), fasting serum glucose, fasting serum insulin and homeostasis model assessment of insulin resistance (HOMA-IR) index. Furthermore, chronic HFD feeding elicited significant increases in serum lipid profile and free fatty acids (FFAs) with concomitant hepatic steatosis. Additionally, serum C-reactive protein (CRP), interleukin 1b (Il-1b) and monocyte chemoattractant protein 1(MCP-1) levels were increased. Also, HFD-fed rats exhibited an increase in MDA level, while superoxide dismutase (SOD) and glutathione (GSH) activities were decreased. Moreover, the insulin-signaling pathway was markedly impaired in soleus muscles as indicated by a decrease in insulin-induced AKT phosphorylation. Histopathologically, adipose tissues showed significant increase in adipocyte size. Also, flow cytometry analysis of adipose tissue confirmed a significant increase in the percentage of number of CD68+ cells. PCA administration succeeded to attenuate HFD-induced obesity, insulin resistance, oxidative stress and inflammation. In conclusion, PCA administration could protect against HFD-induced Mets, possibly via its hypoglycemic, insulin-sensitizing, anti-oxidant and anti-inflammatory effects.
C1 [Nour, Omnia A.; Ghoniem, Hamdy A.; Nader, Manar A.; Suddek, Ghada M.] Mansoura Univ, Fac Pharm, Dept Pharmacol & Toxicol, Mansoura, Egypt.
C3 Egyptian Knowledge Bank (EKB); Mansoura University
RP Nour, OA (corresponding author), Mansoura Univ, Fac Pharm, Dept Pharmacol & Toxicol, Mansoura, Egypt.
EM asilsamy@gmail.com
RI Suddek, Ghada/HPE-4718-2023
OI Suddek, Ghada/0000-0002-3283-9471
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NR 96
TC 12
Z9 12
U1 0
U2 19
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0014-2999
EI 1879-0712
J9 EUR J PHARMACOL
JI Eur. J. Pharmacol.
PD SEP 15
PY 2021
VL 907
AR 174257
DI 10.1016/j.ejphar.2021.174257
EA JUN 2021
PG 19
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA UF3DO
UT WOS:000688457500001
PM 34129881
DA 2025-06-11
ER

PT J
AU Shearer, GC
   Borkowski, K
   Puumala, SL
   Harris, WS
   Pedersen, TL
   Newman, JW
AF Shearer, Gregory C.
   Borkowski, Kamil
   Puumala, Susan L.
   Harris, William S.
   Pedersen, Theresa L.
   Newman, John W.
TI Abnormal lipoprotein oxylipins in metabolic syndrome and partial
   correction by omega-3 fatty acids
SO PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
LA English
DT Article
DE Lipoproteins; VLDL; LDL; HDL; Oxylipins; Lipid mediators; Epoxides;
   Metabolic syndrome; Omega-3 fatty acids; EPA; DHA; Omega-3 acid ethyl
   esters
ID ACTIVATES PPAR-ALPHA; EPOXYEICOSATRIENOIC ACIDS; ENDOTHELIAL-CELLS;
   LIPID MEDIATORS; FATTY-ACIDS; CHOLESTEROL; VLDL; RESOLUTION; HYDROLYSIS;
   OVERWEIGHT
AB Metabolic syndrome (MetSyn) is characterized by chronic inflammation which mediates the associated high risk for cardiovascular and other diseases. Oxylipins are a superclass of lipid mediators with potent bioactivities in inflammation, vascular biology, and more. While their role as locally produced agents is appreciated, most oxylipins in plasma are found in lipoproteins suggesting defective regulation of inflammation could be mediated by the elevated VLDL and low HDL levels characteristic of MetSyn. Our objective was to compare the oxylipin composition of VLDL, LDL, and HDL in 14 optimally healthy individuals and 31 MetSyn patients, and then to determine the effects of treating MetSyn subjects with 4 g/day of prescription omega-3 fatty acids (P-OM3) on lipoprotein oxylipin profiles. We compared oxylipin compositions of healthy (14) and MetSyn (31) subjects followed by randomization and assignment to 4 g/d P-OM3 for 16 weeks using LC/MS/MS. Compared to healthy subjects, MetSyn is characterized by abnormalities of (1) pro-inflammatory, arachidonate-derived oxylipins from the lipoxygenase pathway in HDL; and (2) oxylipins mostly not derived from arachidonate in VLDL. P-OM3 treatment corrected many components of these abnormalities, reducing the burden of inflammatory mediators within peripherally circulating lipoproteins that could interfere with, or enhance, local effectors of inflammatory stress. We conclude that MetSyn is associated with a disruption of lipoprotein oxylipin patterns consistent with greater inflammatory stress, and the partial correction of these dysoxylipinemias by treatment with omega-3 fatty acids could explain some of their beneficial effects.
C1 [Shearer, Gregory C.; Puumala, Susan L.; Harris, William S.] Sanford Res, Sioux Falls, SD USA.
   [Shearer, Gregory C.; Harris, William S.] Univ South Dakota, Sanford Sch Med, Sioux Falls, SD USA.
   [Shearer, Gregory C.; Borkowski, Kamil] Penn State Univ, Dept Nutr Sci, University Pk, PA 16802 USA.
   [Borkowski, Kamil] Univ Calif Davis, UC Davis Genome Ctr, West Coast Metabol Ctr, Davis, CA 95616 USA.
   [Pedersen, Theresa L.; Newman, John W.] ARS, Obes & Metab Res Unit, USDA, Western Human Nutr Res Ctr, Davis, CA USA.
   [Newman, John W.] Univ Calif Davis, Dept Nutr, Davis, CA 95616 USA.
C3 Sanford Health; University of South Dakota; Pennsylvania Commonwealth
   System of Higher Education (PCSHE); Pennsylvania State University; Penn
   State Behrend; Pennsylvania State University - University Park;
   University of California System; University of California Davis; United
   States Department of Agriculture (USDA); University of California
   System; University of California Davis
RP Shearer, GC (corresponding author), Penn State Univ, 110 Chandlee Lab, University Pk, PA 16802 USA.
EM gcs13@psu.edu
RI Shearer, Gregory/B-7309-2014; Harris, William/T-1674-2019
OI Newman, John/0000-0001-9632-6571; Puumala, Susan/0000-0002-6850-6855
FU National Institute of Health [5 R01 DK061486, U24 DK097154]; Abbott
   (Niaspan); GlaxoSmithKline (Lovaza) [LVZ113350]; USDA
   [5306-51530-019-00D, 2032-51530-022-00D]; GlaxoSmithKline [LVZ113350]
FX National Institute of Health (5 R01 DK061486, U24 DK097154) and
   pharmaceuticals from Abbott (Niaspan) and GlaxoSmithKline (Lovaza &
   grant support - LVZ113350), and USDA intramural projects
   5306-51530-019-00D and 2032-51530-022-00D.
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NR 52
TC 36
Z9 39
U1 1
U2 7
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0952-3278
EI 1532-2823
J9 PROSTAG LEUKOTR ESS
JI Prostaglandins Leukot. Essent. Fatty Acids
PD JAN
PY 2018
VL 128
BP 1
EP 10
DI 10.1016/j.plefa.2017.10.006
PG 10
WC Biochemistry & Molecular Biology; Cell Biology; Endocrinology &
   Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology; Endocrinology &
   Metabolism
GA FW3IZ
UT WOS:000425201400002
PM 29413356
OA Bronze
DA 2025-06-11
ER

PT J
AU Rodriguez-Iturbe, B
   Johnson, RJ
   Lanaspa, MA
   Nakagawa, T
   Garcia-Arroyo, FE
   Sánchez-Lozada, LG
AF Rodriguez-Iturbe, Bernardo
   Johnson, Richard J.
   Lanaspa, Miguel A.
   Nakagawa, Takahiko
   Garcia-Arroyo, Fernando E.
   Sanchez-Lozada, Laura G.
TI Sirtuin deficiency and the adverse effects of fructose and uric acid
   synthesis
SO AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY, INTEGRATIVE AND COMPARATIVE
   PHYSIOLOGY
LA English
DT Review
DE fructose; metabolic syndrome; NAD(+); sirtuins; uric acid
ID FATTY LIVER-DISEASE; CHRONIC KIDNEY-DISEASE; OXIDATIVE STRESS;
   INSULIN-RESISTANCE; MITOCHONDRIAL DYSFUNCTION; ENDOTHELIAL DYSFUNCTION;
   NAD(+) HOMEOSTASIS; HEPATIC STEATOSIS; ACTIVATION; HYPERURICEMIA
AB Fructose metabolism and hyperuricemia have been shown to drive insulin resistance, metabolic syndrome, hepatic steatosis, hypertension, inflammation, and innate immune reactivity in experimental studies. We suggest that these adverse effects are at least in part the result of suppressed activity of sirtuins, particularly Sirtuin1. Deficiency of sirtuin deacetylations is a consequence of reduced bioavailability of its cofactor nicotinamide adenine dinucleotide (NAD(+)). Uric acid-induced inflammation and oxidative stress consume NAD(+) and activation of the polyol pathway of fructose and uric acid synthesis also reduces the NAD(+)-to-NADH ratio. Variability in the compensatory regeneration of NAD(+) could result in variable recovery of sirtuin activity that may explain the inconsistent benefits of treatments directed to reduce uric acid in clinical trials. Here, we review the pathogenesis of the metabolic dysregulation driven by hyperuricemia and their potential relationship with sirtuin deficiency. In addition, we discuss therapeutic options directed to increase NAD(+) and sirtuins activity that may improve the adverse effects resulting from fructose and uric acid synthesis.
C1 [Rodriguez-Iturbe, Bernardo] Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Nephrol & Mineral Metab, Mexico City, DF, Mexico.
   [Rodriguez-Iturbe, Bernardo; Garcia-Arroyo, Fernando E.; Sanchez-Lozada, Laura G.] Inst Nacl Cardiol Ignacio Chavez, Dept Cardiorenal Physiopathol, Mexico City, DF, Mexico.
   [Johnson, Richard J.] Univ Colorado, Div Renal Dis & Hypertens, Denver, CO 80202 USA.
   [Johnson, Richard J.] Rocky Mt Reg Vet Affairs Med Ctr, Kidney Dis Div, Denver, CO USA.
   [Lanaspa, Miguel A.] Oregon Hlth & Sci Univ, Div Nephrol & Hypertens, Portland, OR 97201 USA.
   [Nakagawa, Takahiko] Rakuwakai Otowa Hosp, Dept Nephrol, Kyoto, Japan.
C3 Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran -
   Mexico; National Institute of Cardiology - Mexico; University of
   Colorado System; University of Colorado Denver; Oregon Health & Science
   University
RP Rodriguez-Iturbe, B (corresponding author), Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Nephrol & Mineral Metab, Mexico City, DF, Mexico.; Rodriguez-Iturbe, B; Sánchez-Lozada, LG (corresponding author), Inst Nacl Cardiol Ignacio Chavez, Dept Cardiorenal Physiopathol, Mexico City, DF, Mexico.
EM brodriguezIturbe@gmail.com
RI Sanchez-Lozada, Laura/AAS-2104-2021; Rodriguez-Iturbe,
   Bernardo/KFX-2910-2024; Lanaspa, Miguel/AAO-4971-2020
OI Sanchez-Lozada, Laura-Gabriela/0000-0003-0348-9617; Johnson,
   Richard/0000-0003-3312-8193; Garcia Arroyo, Fernando
   Enrique/0000-0003-1545-9765
FU National Institutes of Health [1RO1DK109408-01A1, RO1 DK108859-01];
   Veterans Affairs Merit [BXI01BX004511]; National Institute of Cardiology
   Ignacio Chavez; FONACYT, Venezuela [S1-2001001097, 2005000283]; IVIC,
   Venezuela [803, 1093]
FX GRANTS R. J. Johnson and M. A. Lanaspa were supported by National
   Institutes of Health Grants 1RO1DK109408-01A1 (to R. J.J.) , RO1
   DK108859-01 (to R.J.J.) , and Veterans Affairs Merit BXI01BX004511 (to
   R.J.J.) . Research in L. G. Sanchez-Lozada and F. E. Garcia-Arroyo was
   supported by Direct Expenditure Funds authorized to the Basic Research
   Subdirectorate of the National Institute of Cardiology Ignacio Chavez.
   Research in B. Rodriguez-Iturbe was supported by Grants S1-2001001097
   and 2005000283 (FONACYT, Venezuela) and by Grants 803 and 1093 (IVIC,
   Venezuela) .
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NR 163
TC 8
Z9 8
U1 2
U2 17
PU AMER PHYSIOLOGICAL SOC
PI Rockville
PA 6120 Executive Blvd, Suite 600, Rockville, MD, UNITED STATES
SN 0363-6119
EI 1522-1490
J9 AM J PHYSIOL-REG I
JI Am. J. Physiol.-Regul. Integr. Comp. Physiol.
PD MAY
PY 2022
VL 322
IS 5
BP R347
EP R359
DI 10.1152/ajpregu.00238.2021
PG 13
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA 0N7JB
UT WOS:000783009200001
PM 35271385
OA Green Published
DA 2025-06-11
ER

PT J
AU Berdowska, I
   Matusiewicz, M
   Fecka, I
AF Berdowska, Izabela
   Matusiewicz, Malgorzata
   Fecka, Izabela
TI Methylglyoxal in Cardiometabolic Disorders: Routes Leading to Pathology
   Counterbalanced by Treatment Strategies
SO MOLECULES
LA English
DT Review
DE methylglyoxal; glyoxalase; advanced glycation end products; MG-H1;
   metabolic syndrome; insulin resistance; diabetes mellitus;
   cardiovascular disease; metformin; methylglyoxal scavengers
ID GLYCATION END-PRODUCTS; HUMAN SERUM-ALBUMIN; CORONARY-HEART-DISEASE;
   GLYOXALASE-I OVEREXPRESSION; SMOOTH-MUSCLE-CELLS; INCIDENT
   CARDIOVASCULAR-DISEASE; ALPHA-DICARBONYL COMPOUNDS; LOW-DENSITY
   LIPOPROTEINS; COA REDUCTASE INHIBITOR; MONOCYTIC THP-1 CELLS
AB Methylglyoxal (MGO) is the major compound belonging to reactive carbonyl species (RCS) responsible for the generation of advanced glycation end products (AGEs). Its upregulation, followed by deleterious effects at the cellular and systemic levels, is associated with metabolic disturbances (hyperglycemia/hyperinsulinemia/insulin resistance/hyperlipidemia/inflammatory processes/carbonyl stress/oxidative stress/hypoxia). Therefore, it is implicated in a variety of disorders, including metabolic syndrome, diabetes mellitus, and cardiovascular diseases. In this review, an interplay between pathways leading to MGO generation and scavenging is addressed in regard to this system's impairment in pathology. The issues associated with mechanistic MGO involvement in pathological processes, as well as the discussion on its possible causative role in cardiometabolic diseases, are enclosed. Finally, the main strategies aimed at MGO and its AGEs downregulation with respect to cardiometabolic disorders treatment are addressed. Potential glycation inhibitors and MGO scavengers are discussed, as well as the mechanisms of their action.
C1 [Berdowska, Izabela; Matusiewicz, Malgorzata] Wroclaw Med Univ, Dept Med Biochem, PL-50368 Wroclaw, Poland.
   [Fecka, Izabela] Wroclaw Med Univ, Dept Pharmacognosy & Herbal Med, Wroclaw, Poland.
C3 Wroclaw Medical University; Wroclaw Medical University
RP Berdowska, I (corresponding author), Wroclaw Med Univ, Dept Med Biochem, PL-50368 Wroclaw, Poland.; Fecka, I (corresponding author), Wroclaw Med Univ, Dept Pharmacognosy & Herbal Med, Wroclaw, Poland.
EM izabela.berdowska@umw.edu.pl; malgorzata.matusiewicz@umw.edu.pl;
   izabela.fecka@umw.edu.pl
RI Matusiewicz, Malgorzata/H-1081-2011; Berdowska, Izabela/AAZ-4016-2021;
   Fecka, Izabela/AAS-8974-2021
OI Fecka, Izabela/0000-0002-1139-4581; Matusiewicz,
   Malgorzata/0000-0003-4624-0109
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NR 296
TC 7
Z9 7
U1 7
U2 16
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1420-3049
J9 MOLECULES
JI Molecules
PD DEC
PY 2023
VL 28
IS 23
AR 7742
DI 10.3390/molecules28237742
PG 53
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA AE5A4
UT WOS:001116788500001
PM 38067472
OA Green Submitted, gold, Green Published
DA 2025-06-11
ER

PT J
AU Wahba, NS
   Ghareib, SA
   Abdel-Ghany, RH
   Abdel-Aal, M
   Alsemeh, AE
AF Wahba, Nehal S.
   Ghareib, Salah A.
   Abdel-Ghany, Rasha H.
   Abdel-Aal, Mohamed
   Alsemeh, Amira E.
TI Vitamin D3 potentiates the nephroprotective effects of metformin in a
   rat model of metabolic syndrome: role of AMPK/SIRT1 activation and DPP-4
   inhibition
SO CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
LA English
DT Article
DE metabolic syndrome; nephropathy; metformin; vitamin D3; AMPK/SIRT1;
   DPP-4; RAAS
ID GLYCATION END-PRODUCTS; DENSITY-LIPOPROTEIN CHOLESTEROL;
   RENIN-ANGIOTENSIN SYSTEM; GLUCAGON-LIKE PEPTIDE-1; INSULIN-RESISTANCE;
   DIABETES-MELLITUS; D SUPPLEMENTATION; OXIDATIVE STRESS; HIGH GLUCOSE;
   URIC-ACID
AB The current study aimed to investigate the molecular mechanisms of metformin and vitamin D3-induced nephroprotection in a metabolic syndrome (MetS) rat model, evaluating the capacity of vitamin D3 to potentiate metformin action. MetS was induced by 10% fructose in drinking water and 3% salt in the diet. After 6 weeks, serum lipid profile and uric acid were measured, an oral glucose tolerance test (OGTT) was performed, and kidney function was investigated. In conjunction with the same concentrations of fructose and salt feeding, MetS rats with significant weight gain, dyslipidemia, hyperuricemia, and dysglycemia were treated orally with metformin (200 mg/kg), vitamin D3 (10 lg/kg), or both daily for 6 weeks. At the end of the study period, anthropometrical parameters were recorded, OGTT was reperformed, urine and blood samples were collected, and tissue samples were harvested at sacrifice. MetS rats showed dramatically declined renal function, enhanced intrarenal oxidative stress and inflammation, and extravagant renal histopathological damage with interstitial fibrosis. Metformin and vitamin D3 significantly reversed all the aforementioned deleterious effects in MetS rats. The study has verified the nephroprotective effects of metformin and vitamin D3 in MetS, accentuating the critical role of AMP-activated protein kinase/sirtuin-1 activation and dipeptidyl peptidase-4 inhibition. Given the synergistic effects of the combination, vitamin D3 is worth being investigated as an additional therapeutic agent for preventing MetS-induced nephropathy.
C1 [Wahba, Nehal S.; Ghareib, Salah A.; Abdel-Ghany, Rasha H.; Abdel-Aal, Mohamed] Zagazig Univ, Fac Pharm, Dept Pharmacol & Toxicol, Zagazig, Egypt.
   [Alsemeh, Amira E.] Zagazig Univ, Fac Human Med, Dept Anat & Embryol, Zagazig, Egypt.
C3 Egyptian Knowledge Bank (EKB); Zagazig University; Egyptian Knowledge
   Bank (EKB); Zagazig University
RP Wahba, NS (corresponding author), Zagazig Univ, Fac Pharm, Dept Pharmacol & Toxicol, Zagazig, Egypt.
EM nehalsamirwahba@gmail.com
RI abdalaal, mohamed/JGD-9871-2023; Atteiah, salah/I-1537-2012; Alsemeh,
   Amira/LWH-9728-2024; Wahba, Nehal/AAX-3271-2021
OI Wahba, Nehal/0000-0002-8637-9204; Ghareib, Salah/0009-0005-5718-321X
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NR 108
TC 6
Z9 7
U1 0
U2 9
PU CANADIAN SCIENCE PUBLISHING
PI OTTAWA
PA 65 AURIGA DR, SUITE 203, OTTAWA, ON K2E 7W6, CANADA
SN 0008-4212
EI 1205-7541
J9 CAN J PHYSIOL PHARM
JI Can. J. Physiol. Pharmacol.
PD JUN
PY 2021
VL 99
IS 6
BP 687
EP 699
DI 10.1139/cjpp-2020-0435
PG 13
WC Pharmacology & Pharmacy; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Physiology
GA SW4HR
UT WOS:000664477100014
PM 33108744
DA 2025-06-11
ER

PT J
AU Alemany, M
AF Alemany, Maria
TI Relationship between energy dense diets and white adipose tissue
   inflammation in metabolic syndrome
SO NUTRITION RESEARCH
LA English
DT Review
DE Metabolic syndrome; Inflammation; Endoplasmic reticulum stress;
   Ponderostat; Insulin resistance; White adipose tissue
ID ENDOPLASMIC-RETICULUM STRESS; UNFOLDED PROTEIN RESPONSE; LOW-GRADE
   INFLAMMATION; INSULIN-RESISTANCE; BODY-WEIGHT; ENDOTHELIAL DYSFUNCTION;
   OLEOYL-ESTRONE; BLOOD-FLOW; SUBCLINICAL INFLAMMATION; MACROPHAGE
   INFILTRATION
AB Metabolic syndrome (MS) is a widespread pathologic state that manifests as multiple intertwined diseases affecting the entire body. This review analyzes the contribution of adipose tissue inflammation to its development. The main factor in the appearance of MS is an excess of dietary energy (largely fats), eliciting insulin resistance and creating the problem of excess energy disposal. Under these conditions, amino acid catabolism is diminished, which indirectly alters the production of nitric oxide and affects blood flow regulation. The oxidation of nitric oxide to nitrite and nitrate affects microbiota composition and functions. Adipose tissue cannot incorporate excessive nutrients after cell enlargement and loss of function. Tissue damage is a form of aggression, and the response is proinflammatory cytokine release. Cytokines favor the massive penetration of immune system cells, such as macrophages, which unsuccessfully try to fight an elusive danger for which they are not prepared. The consequence is low-level maintenance of the inflammatory state, which affects endoplasmic reticulum function and the endothelial response to excess regulatory mechanisms affecting blood flow and substrate/oxygen supply. When inflammation becomes chronic, the pathologic consequences are disseminated throughout the body because unused substrates and signals from adipose tissue affect energy partitioning and organ function. This maintenance of an unbalanced state ultimately results in the establishment of MS and associated pathologies. New research should focus on identifying ways to disarm the inflammatory response of adipose tissue when the dangers of dietary excess have already been controlled. (C) 2013 Elsevier Inc. All rights reserved.
C1 [Alemany, Maria] Univ Barcelona, Fac Biol, Dept Nutr & Food Sci, E-08028 Barcelona, Spain.
   [Alemany, Maria] Inst Hlth Carlos III, CIBER Obes & Nutr, Madrid, Spain.
C3 University of Barcelona; CIBER - Centro de Investigacion Biomedica en
   Red; CIBEROBN
RP Alemany, M (corresponding author), Univ Barcelona, Fac Biol, Dept Nutr & Food Sci, 643 Av Diagonal, E-08028 Barcelona, Spain.
EM malemany@ub.edu
RI Alemany, Maria/H-5224-2011
OI Alemany, Maria/0000-0002-9783-8293
FU Plan Nacional de Investigacion en Biomedicina of the Government of Spain
   [SAF2009-11739]
FX This work was supported by grant SAF2009-11739 from the Plan Nacional de
   Investigacion en Biomedicina of the Government of Spain.
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NR 184
TC 21
Z9 25
U1 0
U2 26
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0271-5317
J9 NUTR RES
JI Nutr. Res.
PD JAN
PY 2013
VL 33
IS 1
BP 1
EP 11
DI 10.1016/j.nutres.2012.11.013
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 084TE
UT WOS:000314561200001
PM 23351404
DA 2025-06-11
ER

PT J
AU Koskinen, J
   Magnussen, CG
   Wuertz, P
   Soininen, P
   Kangas, AJ
   Viikari, JSA
   Kahonen, M
   Loo, BM
   Jula, A
   Ahotupa, M
   Lehtimaki, T
   Ala-Korpela, M
   Juonala, M
   Raitakari, OT
AF Koskinen, Juha
   Magnussen, Costan G.
   Wuertz, Peter
   Soininen, Pasi
   Kangas, Antti J.
   Viikari, Jorma S. A.
   Kahonen, Mika
   Loo, Britt-Marie
   Jula, Antti
   Ahotupa, Markku
   Lehtimaki, Terho
   Ala-Korpela, Mika
   Juonala, Markus
   Raitakari, Olli T.
TI Apolipoprotein B, oxidized low-density lipoprotein, and LDL particle
   size in predicting the incidence of metabolic syndrome: the
   Cardiovascular Risk in Young Finns study
SO EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
LA English
DT Article
DE Apolipoproteins; lipids; lipoproteins; metabolic syndrome; oxidative
   stress
ID INTIMA-MEDIA THICKNESS; INSULIN-RESISTANCE; OXIDATIVE STRESS;
   CHOLESTEROL; ASSOCIATION; OBESITY; PLASMA; NUMBER; MEN
AB Objective: To test whether serum apolipoprotein B (apoB) and low-density lipoprotein (LDL) particle characteristics (oxidation and mean particle size) predict the incidence of metabolic syndrome (MetS).
   Methods: The 6-year follow-up study included 1429 adults (baseline mean age 31.5). Lipids, apoB, and apoA1 were measured at baseline in 2001. LDL oxidation was measured with monoclonal antibody-based enzyme-linked immunosorbent assay (oxLDL-prot) and with a method measuring oxidized lipids in LDL (oxLDL-lipids). Mean LDL particle size was calculated from proton nuclear magnetic resonance spectroscopy data.
   Results: Increased concentrations of both oxLDL-measures were associated with increased apoB levels but not with LDL particle size. The odds ratios (95% confidence intervals) for MetS incidence during a 6-year follow up by quartiles of apoB were 2.0 (1.0-3.8) for the second quartile, 3.1 (1.7-5.7) for the third quartile, and 4.2 (2.3-7.6) for the fourth quartile. This association remained after adjusting for age, sex, body mass index, homeostasis model assessment for insulin resistance, C-reactive protein, smoking, LDL cholesterol, oxidized LDL measures (p <= 0.01) in addition to risk factors comprising the MetS (p = 0.03). OxLDL-prot and oxLDL-lipids levels were not independently associated with incident MetS after adjusting for apoB. Mean LDL particle size was not associated with the incidence of MetS.
   Conclusion: ApoB is associated with increased risk of MetS incidence. We found no clear evidence to suggest that increased LDL oxidation or small mean LDL particle size would facilitate the development of MetS.
C1 [Koskinen, Juha; Magnussen, Costan G.; Juonala, Markus; Raitakari, Olli T.] Univ Turku, Turku, Finland.
   [Magnussen, Costan G.] Univ Tasmania, Hobart, Tas 7001, Australia.
   [Wuertz, Peter; Soininen, Pasi; Kangas, Antti J.; Ala-Korpela, Mika] Univ Oulu, Oulu, Finland.
   [Soininen, Pasi; Ala-Korpela, Mika] Univ Eastern Finland, Kuopio, Finland.
   [Viikari, Jorma S. A.; Juonala, Markus; Raitakari, Olli T.] Turku Univ Hosp, FIN-20520 Turku, Finland.
   [Kahonen, Mika; Lehtimaki, Terho] Univ Tampere, FIN-33101 Tampere, Finland.
   [Kahonen, Mika; Lehtimaki, Terho] Tampere Univ Hosp, Tampere, Finland.
   [Loo, Britt-Marie; Jula, Antti] Natl Inst Hlth & Welf, Turku, Finland.
C3 University of Turku; University of Tasmania; University of Oulu;
   University of Eastern Finland; University of Turku; Tampere University;
   Tampere University; Tampere University Hospital; Finland National
   Institute for Health & Welfare
RP Koskinen, J (corresponding author), Univ Turku, Res Ctr Appl & Prevent Cardiovasc Med, Kiinamyllynkatu 10, FI-20520 Turku, Finland.
EM jkkosk@utu.fi
RI Lehtimäki, Terho/AAD-1094-2022; Gratten, Jacob/G-1485-2011; Raitakari,
   Olli/AAQ-7389-2021; Magnussen, Costan/AAA-8260-2020; Magnussen,
   Costan/J-7177-2014
OI Magnussen, Costan/0000-0002-6238-5730; Ala-Korpela,
   Mika/0000-0001-5905-1206; Wurtz, Peter/0000-0002-5832-0221; Juonala,
   Markus/0000-0001-9498-364X; Kahonen, Mika/0000-0002-4510-7341;
   Lehtimaki, Terho/0000-0002-2555-4427; Kangas, Antti/0000-0001-7492-1732
FU Academy of Finland [117797, 121584, 126925, 137870, 129429]; Social
   Insurance Institution of Finland; Instrumentarium Science Foundation;
   Finnish government; Turku University Hospitals; Jenny and Antti Wihuri
   Foundation; Finnish Foundation for Cardiovascular Research; Turku
   University Foundation; Turku University; Juho Vainio Foundation; Lydia
   Maria Julin Foundation; Aarne and Aili Turunen foundation; Tampere
   Tuberculosis Foundation; Finnish Medical Foundation; Paavo Nurmi
   Foundation; Finnish Cultural Foundation; Academy of Finland (AKA)
   [117797, 137870, 129429] Funding Source: Academy of Finland (AKA)
FX This work was supported by the Academy of Finland (grant numbers 117797,
   121584, 126925, 137870, 129429), Social Insurance Institution of
   Finland, Instrumentarium Science Foundation, Finnish government grants
   to Tampere, Kuopio and Turku University Hospitals, Jenny and Antti
   Wihuri Foundation, Finnish Foundation for Cardiovascular Research, Turku
   University Foundation, Turku University, Juho Vainio Foundation, Lydia
   Maria Julin Foundation, Aarne and Aili Turunen foundation, Tampere
   Tuberculosis Foundation, Finnish Medical Foundation, Paavo Nurmi
   Foundation and Finnish Cultural Foundation.
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NR 35
TC 17
Z9 17
U1 0
U2 11
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 2047-4873
EI 2047-4881
J9 EUR J PREV CARDIOL
JI Eur. J. Prev. Cardiol.
PD DEC
PY 2012
VL 19
IS 6
BP 1296
EP 1303
DI 10.1177/1741826711425343
PG 8
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 083ZM
UT WOS:000314505600010
PM 21960651
OA Bronze
DA 2025-06-11
ER

PT J
AU Mochel, JP
   Ward, JL
   Blondel, T
   Kundu, D
   Merodio, MM
   Zemirline, C
   Guillot, E
   Giebelhaus, RT
   de la Mata, P
   Iennarella-Servantez, CA
   Blong, A
   Nam, SL
   Harynuk, JJ
   Suchodolski, J
   Tvarijonaviciute, A
   Cerón, JJ
   Bourgois-Mochel, A
   Zannad, F
   Sattar, N
   Allenspach, K
AF Mochel, Jonathan P.
   Ward, Jessica L.
   Blondel, Thomas
   Kundu, Debosmita
   Merodio, Maria M.
   Zemirline, Claudine
   Guillot, Emilie
   Giebelhaus, Ryland T.
   de la Mata, Paulina
   Iennarella-Servantez, Chelsea A.
   Blong, April
   Nam, Seo Lin
   Harynuk, James J.
   Suchodolski, Jan
   Tvarijonaviciute, Asta
   Ceron, Jose Joaquin
   Bourgois-Mochel, Agnes
   Zannad, Faiez
   Sattar, Naveed
   Allenspach, Karin
TI Preclinical modeling of metabolic syndrome to study the pleiotropic
   effects of novel antidiabetic therapy independent of obesity
SO SCIENTIFIC REPORTS
LA English
DT Article
DE Western diet; Metabolic syndrome; Cardiorenal metabolic diseases; One
   health
ID FERRIC-REDUCING ABILITY; OXIDATIVE STRESS; INSULIN-RESISTANCE;
   BLOOD-PRESSURE; ANIMAL-MODELS; NT-PROBNP; DOG; ASSAY; FAT; VALIDATION
AB Cardiovascular-kidney-metabolic health reflects the interactions between metabolic risk factors, chronic kidney disease, and the cardiovascular system. A growing body of literature suggests that metabolic syndrome (MetS) in individuals of normal weight is associated with a high prevalence of cardiovascular diseases and an increased mortality. The aim of this study was to establish a non-invasive preclinical model of MetS in support of future research focusing on the effects of novel antidiabetic therapies beyond glucose reduction, independent of obesity. Eighteen healthy adult Beagle dogs were fed an isocaloric Western diet (WD) for ten weeks. Biospecimens were collected at baseline (BAS1) and after ten weeks of WD feeding (BAS2) for measurement of blood pressure (BP), serum chemistry, lipoprotein profiling, blood glucose, glucagon, insulin secretion, NT-proBNP, angiotensins, oxidative stress biomarkers, serum, urine, and fecal metabolomics. Differences between BAS1 and BAS2 were analyzed using non-parametric Wilcoxon signed-rank testing. The isocaloric WD model induced significant variations in several markers of MetS, including elevated BP, increased glucose concentrations, and reduced HDL-cholesterol. It also caused an increase in circulating NT-proBNP levels, a decrease in serum bicarbonate, and significant changes in general metabolism, lipids, and biogenic amines. Short-term, isocaloric feeding with a WD in dogs replicated key biological features of MetS while also causing low-grade metabolic acidosis and elevating natriuretic peptides. These findings support the use of the WD canine model for studying the metabolic effects of new antidiabetic therapies independent of obesity.
C1 [Mochel, Jonathan P.; Bourgois-Mochel, Agnes; Allenspach, Karin] Univ Georgia, Coll Vet Med, Dept Pathol, Precis One Hlth Initiat, 501 DW Brooks Dr, Athens, GA 30602 USA.
   [Mochel, Jonathan P.; Kundu, Debosmita; Iennarella-Servantez, Chelsea A.; Bourgois-Mochel, Agnes; Allenspach, Karin] Iowa State Univ, SMART Pharmacol, Ames, IA 50011 USA.
   [Ward, Jessica L.; Merodio, Maria M.; Blong, April] Iowa State Univ, Vet Clin Sci, Ames, IA 50011 USA.
   [Blondel, Thomas; Zemirline, Claudine; Guillot, Emilie] Ceva Sante Anim, F-33500 Libourne, France.
   [Giebelhaus, Ryland T.; de la Mata, Paulina; Nam, Seo Lin; Harynuk, James J.] Univ Alberta, Dept Chem, Metabol Innovat Ctr, Edmonton, AB T6G 2G2, Canada.
   [Suchodolski, Jan] Texas A&M Univ, Gastrointestinal Lab, College Stn, TX 77845 USA.
   [Tvarijonaviciute, Asta; Ceron, Jose Joaquin] Univ Murcia, Interdisciplinary Lab Clin Anal Interlab UMU, Sch Vet, Reg Campus Int Excellence Campus Mare Nostrum, Murcia 30100, Spain.
   [Zannad, Faiez] Univ Lorraine, Ctr Invest Clin Plurithemat 1433, F-54000 Nancy, France.
   [Zannad, Faiez] CHRU Nancy, Inserm U1116, FCRIN INI CRCT, F-54000 Nancy, France.
   [Sattar, Naveed] Univ Glasgow, BHF Glasgow Cardiovasc Res Ctr, Sch Cardiovasc & Metab Hlth, 126 Univ Pl, Glasgow G12 8TA, Lanark, Scotland.
C3 University System of Georgia; University of Georgia; Iowa State
   University; Iowa State University; Ceva Sante Animale; University of
   Alberta; Texas A&M University System; Texas A&M University College
   Station; University of Murcia; Institut National de la Sante et de la
   Recherche Medicale (Inserm); Universite de Lorraine; CHU de Nancy;
   Institut National de la Sante et de la Recherche Medicale (Inserm);
   University of Glasgow
RP Mochel, JP (corresponding author), Univ Georgia, Coll Vet Med, Dept Pathol, Precis One Hlth Initiat, 501 DW Brooks Dr, Athens, GA 30602 USA.; Mochel, JP (corresponding author), Iowa State Univ, SMART Pharmacol, Ames, IA 50011 USA.
EM jpmochel@uga.edu
RI Mochel, Jon/AAR-3496-2021; Blong, April/B-5373-2017; Sattar,
   Naveed/AFN-0504-2022; Harynuk, James/AAJ-9376-2020
OI Mochel, Jonathan/0000-0002-0997-3111; Giebelhaus,
   Ryland/0000-0002-7625-3077
FU Ceva Sante Animale, Libourne (France)
FX This study was sponsored by Ceva Sante Animale, 33500 Libourne (France).
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NR 126
TC 2
Z9 2
U1 2
U2 3
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD SEP 5
PY 2024
VL 14
IS 1
AR 20665
DI 10.1038/s41598-024-71202-y
PG 22
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 0WO2U
UT WOS:001457725800029
PM 39237601
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Feng, GF
   Feng, LM
   Zhao, Y
AF Feng, Guofang
   Feng, Limin
   Zhao, Ying
TI Association between ratio of γ-glutamyl transpeptidase to high-density
   lipoprotein cholesterol and prevalence of nonalcoholic fatty liver
   disease and metabolic syndrome: a cross-sectional study
SO ANNALS OF TRANSLATIONAL MEDICINE
LA English
DT Article
DE Nonalcoholic fatty liver disease (NAFLD); gamma-glutamyl transpeptidase
   (GGT); high-density lipoprotein cholesterol (HDL-C); metabolic syndrome
   (MS)
ID OXIDATIVE STRESS; RISK; STEATOHEPATITIS; TRANSFERASE; PREDICTORS;
   REDUCTION; FIBROSIS; CHILDREN; WEIGHT; CELLS
AB Background: Metabolic risk factors including obesity, insulin resistance, dyslipidemia, metabolic syndrome (MS), and diabetes are associated with nonalcoholic fatty liver disease (NAFLD). gamma-Glutamyl transpeptidase (GGT) and high- density lipoprotein cholesterol (HDL-C) are associated with insulin resistance, dyslipidemia, oxidative stress, and obesity. We investigated the associations between GGT/HDL-C ratio and prevalence of NAFLD in a Chinese population.
   Methods: The study included 1,813 NAFLD (526 females, 1,287 males) and 4,513 non-NAFLD (3,077 females, 1,436 males) participants. The diagnosis of NAFLD was based on ultrasonography.
   Results: Participants with NAFLD had higher GGT/HDL-C ratio, BMI, WC, TG, TC, and HOMAIR, but lower HDL-C than participants without NAFLD. GGT/HDL-C ratio was significantly associated with prevalence of NAFLD. Specifically, for each 1 unit increase in GGT/HDL-C ratio, the prevalence of NAFLD will increase by 0.3%. As GGT/HDL-C ratio quartiles increased, prevalence of NAFLD/MS in Q4 (highest GGT/HDL-C ratio quartile) was 6.362/3.968 times higher than that in Q1 (lowest GGT/HDL-C ratio quartile). The AUC [0.799 (0.788-0.810)] for GGT/HDL-C ratio was significantly higher than those for GGT and HDL-C alone.
   Conclusions: The present results suggest that GGT/HDL-C ratio can be used as a predictive factor for prevalence of NAFLD after adjustment for confounding variables.
C1 [Feng, Guofang] Zhejiang Univ, Womens Hosp, Sch Med, Hangzhou 310006, Peoples R China.
   [Feng, Limin; Zhao, Ying] Zhejiang Univ, Affiliated Hosp 1, Coll Med, Dept Clin Lab, Qingchun Rd 79, Hangzhou 310003, Peoples R China.
   [Feng, Limin; Zhao, Ying] Key Lab Clin In Vitro Diagnost Tech Zhejiang Prov, Qingchun Rd 79, Hangzhou 310003, Peoples R China.
C3 Zhejiang University; Zhejiang University
RP Zhao, Y (corresponding author), Zhejiang Univ, Affiliated Hosp 1, Coll Med, Dept Clin Lab, Qingchun Rd 79, Hangzhou 310003, Peoples R China.; Zhao, Y (corresponding author), Key Lab Clin In Vitro Diagnost Tech Zhejiang Prov, Qingchun Rd 79, Hangzhou 310003, Peoples R China.
EM yingzhao@zju.edu.cn
FU Science and Technology Project [LGF19H040017]; Natural Science
   Foundation [LY20H200005]; Education Department of Zhejiang Province
   [Y201636519]
FX This work was supported by grants from the Science and Technology
   Project (LGF19H040017), Natural Science Foundation (LY20H200005), and
   Education Department (Y201636519) of Zhejiang Province.
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NR 37
TC 32
Z9 35
U1 1
U2 15
PU AME PUBLISHING COMPANY
PI SHATIN
PA FLAT-RM C 16F, KINGS WING PLAZA 1, NO 3 KWAN ST, SHATIN, HONG KONG
   00000, PEOPLES R CHINA
SN 2305-5839
EI 2305-5847
J9 ANN TRANSL MED
JI ANN. TRANSL. MED.
PD MAY
PY 2020
VL 8
IS 10
AR 634
DI 10.21037/atm-19-4516
PG 11
WC Oncology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Research & Experimental Medicine
GA LU8TW
UT WOS:000538022300024
PM 32566571
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Suriyaprom, K
   Kaewprasert, S
   Putpadungwipon, P
   Namjuntra, P
   Klongthalay, S
AF Suriyaprom, Kanjana
   Kaewprasert, Sarunya
   Putpadungwipon, Pumpath
   Namjuntra, Pisit
   Klongthalay, Suwit
TI Association of antioxidant status and inflammatory markers with
   metabolic syndrome in Thais
SO JOURNAL OF HEALTH POPULATION AND NUTRITION
LA English
DT Article
DE Metabolic syndrome; Antioxidant status; Inflammatory markers;
   Hematological parameters; Thai
ID OXIDATIVE STRESS; INSULIN-RESISTANCE; OBESITY; SERUM; ERYTHROCYTES;
   BIOMARKERS; WOMEN
AB BackgroundAn oxidant/antioxidant disequilibrium has been suggested as having a role in the pathogenesis of some diseases. Metabolic syndrome (MS) is significantly associated with cardiovascular disease and type 2 diabetes. The pathogenesis of MS is complex and not well understood. The purposes of the present study were to compare enzymatic and non-enzyme antioxidants, anthropometric, hematological, and biochemical findings between subjects with MS and without MS and to evaluate the relationship between antioxidant status and hematological parameters with the components of MS.MethodsMetabolic syndrome was assessed by using the modified National Cholesterol Education Program, Adult Treatment Panel III criteria. Three hundred Thais, 124 with MS and 176 without MS, were included in the study. Each subject was tested for erythrocyte superoxide dismutase (SOD), glutathione peroxidase, (GPX), catalase (CAT), albumin and vitamin C levels, and hematological findings.ResultsSubjects with MS had lower SOD and CAT levels than those without MS (p<0.01). Subjects with MS had lower vitamin C and albumin levels than those without MS (p<0.05). The hematological findings were not significantly different between those with and without MS except the white blood cell (WBC) count which was significantly higher in those with MS. SOD and CAT levels were significantly positively associated with HDL-C levels and negatively associated with components of MS. After adjusting for potential covariates, we found lower SOD and vitamin C levels and higher WBC counts were significantly associated with MS (p<0.05).ConclusionsThese findings suggest an alteration in antioxidant status and an increase in inflammatory markers are associated with MS and its components among Thais; subjects with MS may be more likely to have oxidative stress problems.
C1 [Suriyaprom, Kanjana; Putpadungwipon, Pumpath; Namjuntra, Pisit; Klongthalay, Suwit] Rangsit Univ, Fac Med Technol, Paholyothin Rd, Pathum Thani 12000, Thailand.
   [Kaewprasert, Sarunya] Mahidol Univ, Fac Trop Med, Dept Trop Nutr & Food Sci, 420-6 Rajvithi Rd, Bangkok 10400, Thailand.
C3 Rangsit University; Mahidol University
RP Suriyaprom, K (corresponding author), Rangsit Univ, Fac Med Technol, Paholyothin Rd, Pathum Thani 12000, Thailand.
EM kanjana.su@rsu.ac.th
RI K, Suriyaprom/H-2911-2019
FU Rangsit University, Thailand
FX The project was supported by funds from Rangsit University, Thailand.
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NR 39
TC 27
Z9 29
U1 1
U2 3
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1606-0997
EI 2072-1315
J9 J HEALTH POPUL NUTR
JI J. Heatlh Popul. Nutr.
PD JAN 3
PY 2019
VL 38
AR 1
DI 10.1186/s41043-018-0158-9
PG 7
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA HG3RC
UT WOS:000454891100001
PM 30606264
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Mancini, A
   Di Segni, C
   Bruno, C
   Olivieri, G
   Guidi, F
   Silvestrini, A
   Meucci, E
   Orlando, P
   Silvestri, S
   Tiano, L
   Pontecorvi, A
AF Mancini, Antonio
   Di Segni, Chantal
   Bruno, Carmine
   Olivieri, Giulio
   Guidi, Francesco
   Silvestrini, Andrea
   Meucci, Elisabetta
   Orlando, Patrick
   Silvestri, Sonia
   Tiano, Luca
   Pontecorvi, Alfredo
TI Oxidative stress in adult growth hormone deficiency: different plasma
   antioxidant patterns in comparison with metabolic syndrome
SO ENDOCRINE
LA English
DT Article
DE Pituitary; Antioxidants; Coenzyme Q10; Insulin-resistance; Metabolic
   syndrome; Precision medicine
ID FACTOR-I; MITOCHONDRIAL PROTECTION; LIFE-SPAN; RESISTANCE
AB Background and aims Growth hormone deficiency (GHD) is a condition associated with increased cardiovascular risk and insulin-resistance. Oxidative stress (OS) could be a mechanism underlying both these phenomena. In order to investigate plasma antioxidant defenses in such condition, we evaluated adults with GHD, compared with controls and metabolic syndrome patients (MetS), studying plasma total antioxidant capacity (TAC) and coenzyme Q10 (CoQ10, lipophilic antioxidant) levels, both in its oxidized and reduced forms, correlating this data with metabolic and hormonal pattern.
   Materials and methods In this case-control study, 51 GHD, 36 controls, and 35 MetS were enrolled. An evaluation of hormonal and metabolic parameters was performed. TAC was measured using the system metmyoglobin -H2O2 and the chromogen ABTS, whose radical form is spectroscopically revealed; latency time (LAG) in the appearance of ABTS. is proportional to antioxidant in sample. CoQ10 was assayed by electrochemical method.
   Results Despite HOMA index was higher in both GHD and MetS (2.2 +/- 0.3 and 3.1 +/- 0.3 vs. 1.2 +/- 0.2 in controls), only in MetS we observed lower LAG levels (64.5 +/- 3.1 s vs. 82.8 +/- 5.8 in GHD and 80.6 +/- 6.6 in controls), suggesting an increased consumption of antioxidants. LAG significantly correlated with uric acid only in MetS (r(2) = 0.65, p < 0.001), suggesting a different pattern of antioxidants. CoQ10 exhibited a trend toward lower levels in GHD, although not significant.
   Conclusions Our data indicate that GHD, although sharing with MetS various metabolic features, including increased HOMA levels, showed a different pattern of plasma antioxidants, suggesting inadequate reactivity toward radical production rather than an antioxidants consumption as in MetS.
C1 [Mancini, Antonio; Di Segni, Chantal; Bruno, Carmine; Olivieri, Giulio; Pontecorvi, Alfredo] Univ Cattolica Sacro Cuore, Operat Unit Endocrinol, Largo A Gemelli 8, I-00168 Rome, Italy.
   [Guidi, Francesco] Univ Cattolica Sacro Cuore, Dept Obstet & Gynecol, Largo A Gemelli 8, I-00168 Rome, Italy.
   [Silvestrini, Andrea; Meucci, Elisabetta] Univ Cattolica Sacro Cuore, Inst Biochem & Clin Biochem, Largo F Vito 1, I-00168 Rome, Italy.
   [Orlando, Patrick; Silvestri, Sonia; Tiano, Luca] Polytech Univ Marche, Dept Life & Environm Sci, Via Brecce Bianche, I-60131 Ancona, Italy.
C3 Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli;
   Catholic University of the Sacred Heart; Catholic University of the
   Sacred Heart; Marche Polytechnic University
RP Mancini, A (corresponding author), Univ Cattolica Sacro Cuore, Operat Unit Endocrinol, Largo A Gemelli 8, I-00168 Rome, Italy.; Silvestrini, A (corresponding author), Univ Cattolica Sacro Cuore, Inst Biochem & Clin Biochem, Largo F Vito 1, I-00168 Rome, Italy.
EM mancini.giac@mclink.it; andrea.silvestrini@unicatt.it
RI Guidi, Francesco/AAS-9209-2021; Bruno, Carmine/CAA-0347-2022; Tiano,
   Luca/ABC-2341-2020; Orlando, Patrick/LSJ-0851-2024; Olivieri,
   Giulio/GXH-8425-2022; Pontecorvi, Alfredo/K-5146-2016; Silvestrini,
   Andrea/B-3410-2009
OI Olivieri, Giulio/0000-0002-8465-3265; Bruno,
   Carmine/0000-0002-3489-0238; Silvestri, Sonia/0000-0003-3302-4335;
   Silvestrini, Andrea/0000-0002-2005-3746; Tiano,
   Luca/0000-0002-7519-7106; PONTECORVI, Alfredo/0000-0003-0570-6865;
   Orlando, Patrick/0000-0002-4203-9611
CR Abdu T. A. M., 2001, CLIN ENDOCRINOL
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NR 45
TC 14
Z9 15
U1 0
U2 5
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1355-008X
EI 1559-0100
J9 ENDOCRINE
JI Endocrine
PD JAN
PY 2018
VL 59
IS 1
BP 130
EP 136
DI 10.1007/s12020-017-1468-1
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA FS6OZ
UT WOS:000419918000016
PM 29143180
DA 2025-06-11
ER

PT J
AU Quetglas-Llabrés, MM
   Monserrat-Mesquida, M
   Bouzas, C
   Mateos, D
   Ugarriza, L
   Gómez, C
   Tur, JA
   Sureda, A
AF Quetglas-Llabres, Maria Magdalena
   Monserrat-Mesquida, Margalida
   Bouzas, Cristina
   Mateos, David
   Ugarriza, Lucia
   Gomez, Cristina
   Tur, Josep A.
   Sureda, Antoni
TI Oxidative Stress and Inflammatory Biomarkers Are Related to High Intake
   of Ultra-Processed Food in Old Adults with Metabolic Syndrome
SO ANTIOXIDANTS
LA English
DT Article
DE ultra-processed food; NOVA; metabolic syndrome; oxidative stress;
   inflammation
ID CONSUMPTION; MYELOPEROXIDASE; ACTIVATION; MECHANISMS; EXPRESSION;
   PLASMA; DIET
AB In the last few decades the consumption of ultra-processed foods (UPFs) worldwide has substantially augmented. Increasing evidence suggests that high UPF consumption is associated with an increase in non-communicable diseases, being overweight, and obesity. The aim of this study was to assess how UPF consumption affects oxidative and inflammatory status in the plasma, neutrophils, and urine of old adults with metabolic syndrome. Participants (n = 92) were classified into two groups according to UPF consumption. Dietary intakes were measured by a validated semi-quantitative 143-item food frequency questionnaire and UPF consumption was determined according to the NOVA classification system. Low UPF consumers showed higher adherence to the Mediterranean diet than high UPF consumers. A high intake of fiber and a high concentration of polyphenols in urine were also observed in subjects with low UPF consumption. Despite the absence of differences in biochemical profile, oxidative and inflammatory biomarkers showed some significant changes. Catalase and superoxide dismutase activities were lower in high UPF consumers, whereas myeloperoxidase activity was higher. ROS production in neutrophils stimulated with zymosan was higher in high UPF consumers than in low UPF consumers. Biomarkers such as xanthine oxidase, tumor necrosis factor a (TNFa), interleukin (IL)-6, IL-15, and leptin levels were higher in participants with high intake of UPF. No differences were found in malondialdehyde and other inflammatory cytokines. The current study evidenced that MetS participants with high UPF consumption have a more pro-oxidant and inflammatory profile than those with low UPF consumption, despite showing similar blood biochemical profiles.
C1 [Quetglas-Llabres, Maria Magdalena; Monserrat-Mesquida, Margalida; Bouzas, Cristina; Mateos, David; Ugarriza, Lucia; Gomez, Cristina; Tur, Josep A.; Sureda, Antoni] Univ Balear Isl IUNICS, Res Grp Community Nutr & Oxidat Stress, Palma De Mallorca 07122, Spain.
   [Quetglas-Llabres, Maria Magdalena; Monserrat-Mesquida, Margalida; Bouzas, Cristina; Mateos, David; Ugarriza, Lucia; Gomez, Cristina; Tur, Josep A.; Sureda, Antoni] Hlth Res Inst Balear Isl IdISBa, Palma De Mallorca 07120, Spain.
   [Monserrat-Mesquida, Margalida; Bouzas, Cristina; Mateos, David; Ugarriza, Lucia; Tur, Josep A.; Sureda, Antoni] Inst Salud Carlos III, Physiopathol Obes & Nutr CIBEROBN, Madrid 28029, Spain.
   [Gomez, Cristina] Univ Hosp Son Espases, Clin Anal Serv, Palma De Mallorca 07198, Spain.
C3 Institut Investigacio Sanitaria Illes Balears (IdISBa); CIBER - Centro
   de Investigacion Biomedica en Red; CIBEROBN; Instituto de Salud Carlos
   III; Hospital Universitari Son Espases
RP Tur, JA (corresponding author), Univ Balear Isl IUNICS, Res Grp Community Nutr & Oxidat Stress, Palma De Mallorca 07122, Spain.; Tur, JA (corresponding author), Hlth Res Inst Balear Isl IdISBa, Palma De Mallorca 07120, Spain.; Tur, JA (corresponding author), Inst Salud Carlos III, Physiopathol Obes & Nutr CIBEROBN, Madrid 28029, Spain.
EM pep.tur@uib.es
RI Tur, Josep/AAE-5748-2020; Bouzas, Cristina/AAE-2069-2019; Mesquida,
   Margalida/AAB-4773-2019; Sureda, Antoni/N-9588-2019; Quetglas Llabrés,
   Maria/AAA-4412-2019; Mateos, David/N-7366-2018; Tur, Josep/F-5576-2014
OI , Antoni/0000-0001-8656-6838; GOMEZ COBO, CRISTINA/0000-0002-9776-4730;
   Monserrat Mesquida, Margalida/0000-0002-8856-135X; Tur,
   Josep/0000-0002-6940-0761; Bouzas Velasco, Cristina/0000-0002-1407-8461;
   Quetglas Llabres, Maria Magdalena/0000-0003-4155-7780
FU The authors especially thank the participants for their enthusiastic
   collaboration, the personnel for outstanding support, and exceptional
   effort. CIBEROBN is an initiative of Instituto de Salud Carlos III,
   Spain.; CIBEROBN is an initiative of Instituto de Salud Carlos III,
   Spain
FX The authors especially thank the participants for their enthusiastic
   collaboration, the personnel for outstanding support, and exceptional
   effort. CIBEROBN is an initiative of Instituto de Salud Carlos III,
   Spain.
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NR 57
TC 16
Z9 16
U1 0
U2 4
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD AUG
PY 2023
VL 12
IS 8
AR 1532
DI 10.3390/antiox12081532
PG 14
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA Q2QM2
UT WOS:001056012900001
PM 37627527
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Chung, JY
   Seo, MS
   Shim, JY
   Lee, YJ
AF Chung, Ji-Youn
   Seo, Min-Seok
   Shim, Jae-Yong
   Lee, Yong-Jae
TI Sex differences in the relationship between blood mercury concentration
   and metabolic syndrome risk
SO JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
LA English
DT Article
DE Mercury; Metabolic syndrome; Oxidative stress; Sex differences
ID OXIDATIVE STRESS; METHYLMERCURY EXPOSURE; MYOCARDIAL-INFARCTION;
   LIPID-PEROXIDATION; INSULIN-RESISTANCE; INORGANIC MERCURY; KOREAN
   ADULTS; TREATED RATS; HEALTH; NEUROTOXICITY
AB Background Mercury exposure enhances free radical production and reduces activity of anti-oxidant enzymes, resulting in detrimental health effects. Some researchers have reported an association between blood mercury and increased risk of metabolic syndrome (MetS); however, sex differences in the relationship were not fully considered.
   Aim To examine the sex differences in the relationship between blood mercury concentration and the increased risk of MetS in Korean men and women.
   Materials and methods A nationwide cross-sectional study was conducted to examine the relationship between blood mercury concentration and MetS in 2,976 men and 3,074 women over 19 years of age (aged 19-87 years), using data from the 2010-2012 Korean National Health and Nutrition Examination Survey (KNHANES-V). Multiple logistic regression analysis was used to assess the relationship between blood mercury concentration and the prevalence risk of MetS after adjusting for confounding variables.
   Results Compared to the lowest quartile of blood mercury concentration, the OR (95 % CI) for MetS of the highest quartile in men was 1.62 (1.15-2.28) after adjusting for age, smoking status, alcohol consumption, regular exercise, and BMI. Similarly, in multiple logistic regression analysis using log2-transformed blood mercury as a continuous variable, the OR (95 % CI) for having MetS with doubling of blood mercury was 1.20 (1.05-1.36) after adjusting for the same co-variables. However, the relationship was not observed in women after adjusting for the same co-variables.
   Conclusions Blood mercury concentration was independently associated with an increased risk of MetS in men.
C1 [Chung, Ji-Youn] Seoul Red Cross Hosp, Dept Family Med, Seoul, South Korea.
   [Seo, Min-Seok; Shim, Jae-Yong; Lee, Yong-Jae] Yonsei Univ, Coll Med, Dept Family Med, Seoul 135720, South Korea.
   [Seo, Min-Seok] Yonsei Univ, Grad Sch Med, Seoul 120749, South Korea.
C3 Yonsei University; Yonsei University Health System; Yonsei University
RP Lee, YJ (corresponding author), Yonsei Univ, Coll Med, Dept Family Med, 211 Eonju Ro, Seoul 135720, South Korea.
EM ukyjhome@yuhs.ac
RI Lee, Yong Jae/GLR-4153-2022; Shim, Jae Yong/GLU-2862-2022; Seo,
   Minseok/JXM-0791-2024
OI Seo, Minseok/0000-0001-5551-4891; Shim, JaeYong/0000-0002-9561-9230;
   Lee, Yong-Jae/0000-0002-6697-476X
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NR 35
TC 19
Z9 19
U1 0
U2 9
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1720-8386
J9 J ENDOCRINOL INVEST
JI J. Endocrinol. Invest.
PD JAN
PY 2015
VL 38
IS 1
BP 65
EP 71
DI 10.1007/s40618-014-0132-3
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA CC9IH
UT WOS:000350681800007
PM 25053396
DA 2025-06-11
ER

PT J
AU Title, LM
   Lonn, E
   Charbonneau, F
   Fung, M
   Mather, KJ
   Verma, S
   Anderson, TJ
AF Title, Lawrence M.
   Lonn, Evan
   Charbonneau, Francois
   Fung, Marinda
   Mather, Kieren J.
   Verma, Subodh
   Anderson, Todd J.
TI Relationship between brachial artery flow-mediated dilatation, hyperemic
   shear stress, and the metabolic syndrome
SO VASCULAR MEDICINE
LA English
DT Article
DE endothelium; insulin resistance; metabolic syndrome; obesity;
   vasodilation
ID INSULIN-RESISTANCE; ENDOTHELIAL FUNCTION; NITRIC-OXIDE; DISEASE;
   VASODILATION; DYSFUNCTION; DILATION; ADULTS; ASSOCIATION; REACTIVITY
AB Metabolic syndrome (MetSyn) may predispose to cardiovascular disease (CVD) by causing vascular dysfunction. This study aimed to determine the association of MetSyn with vascular function, as assessed by brachial artery flow-mediated dilatation (FMD) and hyperemic shear stress (HSS). A total of 1,417 male firefighters without established diabetes and CVD were classified for MetSyn, according to the National Cholesterol Education Program Adult Treatment Panel III (NCEP) definition. MetSyn was present in 267 individuals (19%). Although FMD was lower in those with versus without MetSyn (8.1 +/- 4.1 vs 8.7 +/- 4.0%; p = 0.02), this was not significant after adjusting for baseline differences (age, smoking, and brachial artery diameter) (p = 0.2). However, HSS was significantly lower in those with versus without MetSyn (72.0 +/- 27.8 vs 80.9 +/- 24.8 dyne/cm(2); p < 0.001), and there was a significant inverse graded relationship with the number of NCEP criteria present (mean HSS for those with 0, 1, 2, 3, 4, and 5 criteria: 83.2 +/- 22.5, 82.2 +/- 24.7, 76.5 +/- 27.2, 74.3 +/- 27.4, 66.5 +/- 28.4, 67.1 +/- 27.6 dyne/cm(2); p < 0.001 for trend). The individual NCEP criteria of abdominal obesity, systolic hypertension, and impaired fasting glucose were independent predictors for HSS. In conclusion, MetSyn was not associated with impaired FMD. Alternatively, HSS, a measure of microvascular function, was significantly lower in those with MetSyn. Thus, MetSyn may contribute to CVD by causing microvascular dysfunction.
C1 [Title, Lawrence M.] Dalhousie Univ, Div Cardiol, Halifax, NS, Canada.
   [Lonn, Evan] McMaster Univ, Div Cardiol, Hamilton, ON, Canada.
   [Charbonneau, Francois; Fung, Marinda; Anderson, Todd J.] Univ Calgary, Div Cardiol, Calgary, AB, Canada.
   [Mather, Kieren J.] Indiana Univ, Div Endocrinol, Indianapolis, IN 46204 USA.
   [Verma, Subodh] Univ Toronto, Div Cardiovasc Surg, Toronto, ON, Canada.
C3 Dalhousie University; McMaster University; University of Calgary;
   Indiana University System; Indiana University Indianapolis; University
   of Toronto
RP Title, LM (corresponding author), Queen Elizabeth 2 Hlth Sci Ctr, Div Cardiol, 6876-1796 Summer St, Halifax, NS B3H 3A7, Canada.
EM ltitle@dal.ca
RI Verma, Subodh/HCH-3619-2022; Mather, Kieren/ABE-4117-2020
FU Heart and Stroke Foundation of Alberta; Canadian Institute of Health
   Research; Pfizer Canada
FX This study was supported by grants from the Heart and Stroke Foundation
   of Alberta, Canadian Institute of Health Research, and Pfizer Canada.
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NR 35
TC 35
Z9 41
U1 0
U2 1
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1358-863X
EI 1477-0377
J9 VASC MED
JI Vasc. Med.
PD NOV
PY 2008
VL 13
IS 4
BP 263
EP 270
DI 10.1177/1358863X08095154
PG 8
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 364MK
UT WOS:000260339600004
PM 18940902
OA Green Published
DA 2025-06-11
ER

PT J
AU Wilar, G
   Suhandi, C
   Fukunaga, K
   Shigeno, M
   Kawahata, I
   Abdulah, R
   Sasaki, T
AF Wilar, Gofarana
   Suhandi, Cecep
   Fukunaga, Kohji
   Shigeno, Masanori
   Kawahata, Ichiro
   Abdulah, Rizky
   Sasaki, Takuya
TI Effects of nanocurcumin supplementation on metabolic syndrome: A
   systematic review and meta-analysis of randomized controlled trials
SO PHARMACOLOGICAL RESEARCH
LA English
DT Review
DE Nanocurcumin; Metabolic syndrome; Inflammatory markers; Oxidative
   stress; Meta-analysis
ID DOUBLE-BLIND; DIABETES-MELLITUS; NANO-CURCUMIN; HEMODIALYSIS;
   INFLAMMATION; DIFFERENCE; DIAGNOSIS; MARKERS
AB Background: Metabolic syndrome (MetS) encompasses metabolic risk factors like elevated blood glucose, abnormal lipid levels, and hypertension. Nanocurcumin, a nanoscale formulation of curcumin, may offer therapeutic benefits for MetS management. This systematic review and meta-analysis evaluates the impact of nanocurcumin supplementation on key MetS parameters. Methods: A systematic literature search identified 20 randomized controlled trials (RCTs) with 1394 participants. Data were pooled using a random-effects model, and standardized mean differences (SMDs) were calculated for key outcomes. Results: Nanocurcumin supplementation significantly improved waist circumference (WC) (standardized mean difference (SMD): -0.30 cm), fasting blood sugar (FBS) (SMD: -0.34 mg/dL), HbA1c (SMD: -0.33 %), and quantitative insulin sensitivity check index (QUICKI) score (SMD: 0.73). Lipid profile parameters, including total cholesterol (SMD: -0.18 mg/dL), LDL-C (SMD: -0.16 mg/dL), and HDL-C (SMD: 0.32 mg/dL), also reduced significantly. Improvement in diastolic blood pressure (DBP) (SMD: -0.32 mmHg), total antioxidant capacity (TAC) (SMD: 0.44 mmol/L), malondialdehyde (MDA) (SMD: -0.37 mmol/L), tumor necrosis factor-alpha (TNF-alpha) (SMD: -2.30 ng/L), interleukin-6 (IL-6) (SMD: -1.07 ng/L), and high-sensitivity C-reactive protein (hs-CRP) (SMD: -0.34 mg/L) were observed. Conclusion: Nanocurcumin supplementation significantly improves multiple MetS-related parameters, including anthropometric measures, glycemic control, lipid profile, blood pressure, oxidative stress markers, and inflammatory biomarkers. These findings highlight nanocurcumin's potential as an effective adjunctive therapy for managing MetS. However, the variability in study participant ages, treatment durations, and sample sizes suggests the need for further well-designed RCTs to establish optimal usage guidelines.
C1 [Wilar, Gofarana; Suhandi, Cecep; Abdulah, Rizky] Univ Padjadjaran, Fac Pharm, Dept Pharmacol & Clin Pharm, Sumedang 45363, Indonesia.
   [Suhandi, Cecep] Univ Padjadjaran, Fac Pharm, Dept Pharmaceut & Pharmaceut Technol, Sumedang 45363, Indonesia.
   [Fukunaga, Kohji; Kawahata, Ichiro; Sasaki, Takuya] Tohoku Univ, Grad Sch Pharmaceut Sci, Dept Pharmacol, Sendai 9808578, Japan.
   [Fukunaga, Kohji] Tohoku Univ, Grad Sch Pharmaceut Sci, Dept CNS Drug Innovat, Sendai 9808578, Japan.
   [Shigeno, Masanori] Tohoku Univ, Grad Sch Pharmaceut Sci, Dept Biophys Chem, Sendai 9808578, Japan.
C3 Universitas Padjadjaran; Universitas Padjadjaran; Tohoku University;
   Tohoku University; Tohoku University
RP Wilar, G (corresponding author), Univ Padjadjaran, Fac Pharm, Dept Pharmacol & Clin Pharm, Sumedang 45363, Indonesia.
EM g.wilar@unpad.ac.id
RI Abdulah, Rizky/A-6282-2015; Kawahata, Ichiro/A-6443-2017
OI Kawahata, Ichiro/0000-0002-5916-7847
FU Article Review Grant from Universitas Padjadjaran
   [2357/UN6.3.1/PT.00/2024]; Kakenhi
FX This work was primarily supported by the Article Review Grant from
   Universitas Padjadjaran (grant numbers 2357/UN6.3.1/PT.00/2024) (GW) and
   additionally supported by Kakenhi (IK) .
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NR 79
TC 1
Z9 1
U1 1
U2 1
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 1043-6618
EI 1096-1186
J9 PHARMACOL RES
JI Pharmacol. Res.
PD MAR
PY 2025
VL 213
AR 107641
DI 10.1016/j.phrs.2025.107641
EA FEB 2025
PG 20
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA W6H3T
UT WOS:001419557800001
PM 39894187
OA hybrid
DA 2025-06-11
ER

PT J
AU Goutzourelas, N
   Orfanou, M
   Charizanis, I
   Leon, G
   Spandidos, DA
   Kouretas, D
AF Goutzourelas, Nikolaos
   Orfanou, Marina
   Charizanis, Ioannis
   Leon, George
   Spandidos, Demetrios A.
   Kouretas, Demetrios
TI GSH levels affect weight loss in individuals with metabolic syndrome and
   obesity following dietary therapy
SO EXPERIMENTAL AND THERAPEUTIC MEDICINE
LA English
DT Article
DE metabolic syndrome; obesity; oxidative stress; glutathione; weight loss
ID GLUTATHIONE-S-TRANSFERASE; TYPE-2 DIABETES-MELLITUS; ALPHA-KETOGLUTARATE
   DEHYDROGENASE; OXIDATIVE STRESS; INSULIN-RESISTANCE; LIPID-METABOLISM;
   REDOX STATUS; LIPOIC ACID; EXERCISE; COMPLICATIONS
AB This study examined the effects of redox status markers on metabolic syndrome (MetS) and obesity before and after dietary intervention and exercise for weight loss. A total of 103 adults suffering from MetS and obesity participated in this study and followed a personalized diet plan for 6 months. Body weight, body fat (BF) percentage (BF%), respiratory quotient (RQ) and the redox status markers, reduced glutathione (GSH), thiobarbituric acid reactive substances (TBARS) and protein carbonyls (CARB), were measured twice in each individual, before and after intervention. Dietary intervention resulted in weight loss, a reduction in BF% and a decrease in RQ. The GSH levels were significantly decreased following intervention, while the levels of TBARS and CARB were not affected Based on the initial GSH levels, the patients were divided into 2 groups as follows: The high GSH group (GSH, >3.5 mu mol/g Hb) and the low GSH group (GSH <3.5 mu mol/g Hb). Greater weight and BF loss were observed in patients with high GSH levels. It was observed that patients with MetS and obesity with high GSH values responded better to the dietary therapy, exhibiting more significant changes in weight and BF%. This finding underscores the importance of identifying redox status markers, particularly GSH, in obese patients with MetS. Knowing the levels of GSH may aid in developing a better design of an individualized dietary plan for individuals who wish to lose weight.
C1 [Goutzourelas, Nikolaos; Kouretas, Demetrios] Univ Thessaly, Dept Biochem & Biotechnol, Viopolis 41500, Larissa, Greece.
   [Goutzourelas, Nikolaos; Orfanou, Marina; Leon, George] Eatwalk IKE, Athens 15124, Greece.
   [Charizanis, Ioannis] Obes Med Ctr, Thessaloniki 55133, Greece.
   [Spandidos, Demetrios A.] Univ Crete, Med Sch, Lab Clin Virol, Iraklion 71409, Greece.
C3 University of Crete
RP Kouretas, D (corresponding author), Univ Thessaly, Dept Biochem & Biotechnol, Viopolis 41500, Larissa, Greece.
EM dkouret@uth.gr
RI KOURETAS, DEMETRIOS/ABE-8519-2020
OI Spandidos, Demetrios/0000-0002-1146-931X
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NR 74
TC 18
Z9 23
U1 0
U2 0
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1792-0981
EI 1792-1015
J9 EXP THER MED
JI Exp. Ther. Med.
PD AUG
PY 2018
VL 16
IS 2
BP 635
EP 642
DI 10.3892/etm.2018.6204
PG 8
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA GR1GO
UT WOS:000442280500023
PM 30116319
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Aguilera-Méndez, A
   Alvarez-Delgado, C
   Hernández-Godinez, D
   Fernandez-Mejia, C
AF Aguilera-Mendez, Asdrubal
   Alvarez-Delgado, Carolina
   Hernandez-Godinez, Daniel
   Fernandez-Mejia, Cristina
TI Hepatic Diseases Related to Triglyceride Metabolism
SO MINI-REVIEWS IN MEDICINAL CHEMISTRY
LA English
DT Review
DE Hepatic disease; inflammation; insulin resistance; liver; metabolism;
   triglycerides
ID FATTY LIVER-DISEASE; ENDOPLASMIC-RETICULUM STRESS; NONALCOHOLIC
   STEATOHEPATITIS; HEPATOCELLULAR-CARCINOMA; GUT MICROBIOTA; RISK-FACTORS;
   PROTEIN; MECHANISMS; STEATOSIS; ACTIVATION
AB Triglycerides participate in key metabolic functions such as energy storage, thermal insulation and as deposit for essential and non-essential fatty acids that can be used as precursors for the synthesis of structural and functional phospholipids. The liver is a central organ in the regulation of triglyceride metabolism, and it participates in triglyceride synthesis, export, uptake and oxidation. The metabolic syndrome and associated diseases are among the main concerns of public health worldwide. One of the metabolic syndrome components is impaired triglyceride metabolism. Diseases associated with the metabolic syndrome promote the appearance of hepatic alterations e. g., non-alcoholic steatosis, steatohepatitis, fibrosis, cirrhosis and cancer. In this article, we review the molecular actions involved in impaired triglyceride metabolism and its association with hepatic diseases. We discuss mechanisms that reconcile the chronic inflammation and insulin resistance, and new concepts on the role of intestinal micro-flora permeability and proliferation in fatty liver etiology. We also describe the participation of oxidative stress in the progression of events leading from steatosis to steatohepatitis and fibrosis. Finally, we provide information regarding the mechanisms that link fatty acid accumulation during steatosis with changes in growth factors and cytokines that lead to the development of neoplastic cells. One of the main medical concerns vis-a-vis hepatic diseases is the lack of symptoms at the onset of the illness and, as result, its late diagnosis. The understandings of the molecular mechanisms that underlie hepatic diseases could help design strategies towards establishing markers for their accurate and timely diagnosis.
C1 [Aguilera-Mendez, Asdrubal; Hernandez-Godinez, Daniel] Univ Michoacana, Morelia 58030, Michoacan, Mexico.
   [Aguilera-Mendez, Asdrubal; Alvarez-Delgado, Carolina; Fernandez-Mejia, Cristina] Univ Nacl Autonoma Mexico, Inst Invest Biomed, Unidad Genet Nutr, Inst Nacl Pediat, Mexico City 04530, DF, Mexico.
C3 Universidad Michoacana de San Nicolas de Hidalgo; Universidad Nacional
   Autonoma de Mexico
RP Fernandez-Mejia, C (corresponding author), Univ Nacl Autonoma Mexico, Inst Invest Biomed, Unidad Genet Nutr, Inst Nacl Pediat, Av Iman 1,Cuarto Piso, Mexico City 04530, DF, Mexico.
EM crisfern@biomedicas.unam.mx
RI Aguilera-Méndez, Asdrubal/AAG-4797-2020; Alvarez-Delgado,
   Carolina/B-8195-2015
OI Aguilera Mendez, Asdrubal/0000-0003-0326-2068; Alvarez-Delgado,
   Carolina/0000-0002-4567-1081
FU Consejo Nacional de Ciencia y Tecnologia [99294-M]; Direccion General de
   Asuntos del Personal Academico, Universidad Nacional Autonoma de Mexico
   [IN214811]; CONACYT [99294-M, CVU/Becario 91634]; PROMEP [UMSNH-208];
   Instituto de Ciencia y Tecnologia del Distrito Federal (ICyTDF)
   [ICYTDF/SRI/PB/4/2012]
FX Supported by a research grant from the Consejo Nacional de Ciencia y
   Tecnologia 99294-M, the Direccion General de Asuntos del Personal
   Academico, Universidad Nacional Autonoma de Mexico IN214811. Asdrubal
   Aguilera is recipient of the CONACYT and PROMEP scholarship number
   CVU/Becario 91634 and UMSNH-208 respectively. Carolina Alvarez-Delgado
   is a recipient of a postdoctoral fellowship stipend from CONACyT
   (99294-M) and from the Instituto de Ciencia y Tecnologia del Distrito
   Federal (ICyTDF), fellowship: ICYTDF/SRI/PB/4/2012. We acknowledge that
   the authors Asdrubal Aguilera-Mendez, Carolina Alvarez-Delgado, Daniel
   Hernandez-Godinez and Cristina Fernandez-Mejia have no financial
   interest or other contractual agreements that might cause conflicts of
   interest or be perceived as causing conflicts of interest in any company
   or organization sponsoring the research.
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NR 67
TC 14
Z9 14
U1 1
U2 27
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1389-5575
EI 1875-5607
J9 MINI-REV MED CHEM
JI Mini-Rev. Med. Chem.
PD OCT
PY 2013
VL 13
IS 12
BP 1691
EP 1699
PG 9
WC Chemistry, Medicinal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 220IR
UT WOS:000324576900001
PM 24059726
DA 2025-06-11
ER

PT J
AU Mainini, G
   Ercolano, S
   De Simone, R
   Iavarone, I
   Lizza, R
   Passaro, M
AF Mainini, Giampaolo
   Ercolano, Salvatore
   De Simone, Raffaella
   Iavarone, Irene
   Lizza, Rosalia
   Passaro, Mario
TI Dietary Supplementation of Myo-Inositol, Cocoa Polyphenols, and Soy
   Isoflavones Improves Vasomotor Symptoms and Metabolic Profile in
   Menopausal Women with Metabolic Syndrome: A Retrospective Clinical Study
SO MEDICINA-LITHUANIA
LA English
DT Article
DE menopause; metabolic syndrome; vasomotor symptoms; myo-Inositol; cocoa
   polyphenols; soy isoflavones
ID POSTMENOPAUSAL WOMEN; BLOOD-PRESSURE; PREVENTION; MANAGEMENT; HORMONE;
   DISEASE; HEALTH
AB Background and Objectives: Hormonal changes physiologically occurring in menopausal women may increase the risk of developing metabolic and vasomotor disturbances, which contribute to increase the risk of developing other concomitant pathologies, such as metabolic syndrome (MetS). Materials and Methods: Retrospective data from 200 menopausal women with MetS and vasomotor symptoms taking one sachet per day of the dietary supplement INOFOLIC (R) NRT (Farmares srl, Rome, Italy) were collected. Each sachet consisted of myo-Inositol (2000 mg), cocoa polyphenols (30 mg), and soy isoflavones (80 mg, of which 50 mg is genistin). Patients recorded their symptoms through a medical questionnaire at the beginning of the administration (T0) and after 6 months (T1). Results: We observed an improvement in both the frequency and the severity of hot flushes: increased percentage of 2-3 hot flushes (28 at T0 vs. 65% at T1, p value < 0.001) and decreased percentage of 4-9 hot flushes (54% at T0 vs. 18% at T1, p value < 0.001). Moreover, symptoms of depression improved after supplementation (87% at T0 vs. 56% at T1 of patients reported moderate depression symptoms, p value < 0.001). Regarding metabolic profile, women improved body mass index and waist circumference with a reduction in the percentage of overweight and obesity women (88% at T0 vs. 51% at T1, p value = 0.01; 14% at T0 vs. 9% at T1, p value = 0.04). In addition, the number of women suffering from non-insulin dependent diabetes reduced (26% at T0 vs. 16% at T1, p value = 0.04). Conclusions: These data corroborate previously observed beneficial effects of the oral administration of myo-Inositol, cocoa polyphenols, and soy isoflavones against menopausal symptoms in the study population. Considering the promising results of the present study, further prospective controlled clinical trials are needed to deeply understand and support the efficacy of these natural compounds for the management of menopausal symptoms.
C1 [Mainini, Giampaolo; Ercolano, Salvatore; De Simone, Raffaella; Iavarone, Irene; Lizza, Rosalia; Passaro, Mario] Soc Campano Calabro Apulo Lucana Ginecol Ostetrici, I-80133 Naples, Italy.
RP Mainini, G (corresponding author), Soc Campano Calabro Apulo Lucana Ginecol Ostetrici, I-80133 Naples, Italy.
EM giampaolomainini@libero.it
RI Iavarone, Irene/JQP-0981-2023
OI Iavarone, Irene/0000-0003-3057-661X
FU Farmares s.r.l, Rome, Italy
FX No Statement Available
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NR 52
TC 3
Z9 3
U1 1
U2 3
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1010-660X
EI 1648-9144
J9 MEDICINA-LITHUANIA
JI Med. Lith.
PD APR
PY 2024
VL 60
IS 4
AR 598
DI 10.3390/medicina60040598
PG 11
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA PA0W2
UT WOS:001211251700001
PM 38674244
OA gold
DA 2025-06-11
ER

PT J
AU Thaker, PH
   Sood, AK
   Ramondetta, LM
AF Thaker, Premal H.
   Sood, Anil K.
   Ramondetta, Lois M.
TI Importance of adrenergic pathways in women's cancers
SO CANCER BIOMARKERS
LA English
DT Article
DE Gynecologic malignancies; adrenergic pathways; ovarian cancer;
   endometrial cancer; cervical cancer
ID ENDOTHELIAL GROWTH-FACTOR; SQUAMOUS-CELL CARCINOMA;
   POLYCYSTIC-OVARY-SYNDROME; CERVICAL-CANCER; TUMOR ANGIOGENESIS;
   UP-REGULATION; METABOLIC SYNDROME; SOCIAL SUPPORT; CHRONIC STRESS;
   RISK-FACTORS
AB The importance of adrenergic pathways in cancer has long been suspected, but now there is mounting epidemiological, preclinical, and clinical evidence of its importance in gynecologic cancers. To date, most of these effects are mediated primarily through the beta 2 adrenergic receptor activation of the tumor cell cyclic AMP-protein kinase A signaling pathway. This review will discuss the current knowledge about the neuroendocrine stress response in gynecologic tumor biology.
C1 [Thaker, Premal H.] Washington Univ, Sch Med, St Louis, MO USA.
   [Sood, Anil K.; Ramondetta, Lois M.] Univ Texas MD Anderson Canc Ctr, Dept Gynecol Oncol, Houston, TX 77030 USA.
   [Sood, Anil K.] Univ Texas MD Anderson Canc Ctr, Dept Canc Biol, Houston, TX 77030 USA.
   [Sood, Anil K.] Univ Texas MD Anderson Canc Ctr, Ctr RNA Interference & Noncoding RNA, Houston, TX 77030 USA.
C3 Washington University (WUSTL); University of Texas System; UTMD Anderson
   Cancer Center; University of Texas System; UTMD Anderson Cancer Center;
   University of Texas System; UTMD Anderson Cancer Center
RP Ramondetta, LM (corresponding author), Univ Texas MD Anderson Canc Ctr, Dept Gynecol Oncol, 1155 Herman Pressler Unit 1362, Houston, TX 77030 USA.
EM thakerp@wudosis.wustl.edu; lramonde@mdanderson.org
FU National Institutes of Health [CA109298, CA140933-01, P50 CA083639, P50
   CA098258, U54 CA151668]
FX Financial support was provided by the National Institutes of Health
   (CA109298, CA140933-01, P50 CA083639, P50 CA098258, U54 CA151668).
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NR 92
TC 15
Z9 16
U1 0
U2 5
PU IOS PRESS
PI AMSTERDAM
PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS
SN 1574-0153
EI 1875-8592
J9 CANCER BIOMARK
JI Cancer Biomark.
PY 2013
VL 13
IS 3
BP 145
EP 154
DI 10.3233/CBM-130324
PG 10
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA 195QQ
UT WOS:000322719100003
PM 23912486
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Reljic, D
   Herrmann, HJ
   Neurath, MF
   Zopf, Y
AF Reljic, Dejan
   Herrmann, Hans J.
   Neurath, Markus F.
   Zopf, Yurdagul
TI Iron Beats Electricity: Resistance Training but Not Whole-Body
   Electromyostimulation Improves Cardiometabolic Health in Obese Metabolic
   Syndrome Patients during Caloric Restriction-A Randomized-Controlled
   Study
SO NUTRIENTS
LA English
DT Article
DE exercise; obesity; fasting; muscle mass; strength training;
   cardiovascular disease; hypertension; electrical stimulation; muscular
   strength; psychological health
ID MUSCLE-FIBER-TYPE; INDIVIDUALIZED NUTRITIONAL SUPPORT; WEIGHT-LOSS
   INTERVENTIONS; HUMAN SKELETAL-MUSCLE; QUALITY-OF-LIFE;
   PHYSICAL-ACTIVITY; SARCOPENIC OBESITY; BLOOD-PRESSURE; PROTEIN
   SUPPLEMENTATION; ENERGY-RESTRICTION
AB Caloric restriction (CR) and exercise are cornerstones in the treatment of obesity and cardiometabolic disorders. Recently, whole body electromyostimulation (WB-EMS) has emerged as a more time-efficient alternative to traditional resistance training (RT). However, the effects of WB-EMS compared to RT on cardiometabolic health in obese metabolic syndrome (MetS) patients performed during CR are still unclear. In total, 118 obese MetS patients (52.7 +/- 11.8 years, BMI: 38.1 +/- 6.9 kg/m(2)) undergoing CR over 12 weeks (aim: -500 kcal deficit/day) were randomly allocated to either WB-EMS, single-set RT (1-RT), 3-set RT (3-RT) or an inactive control group (CON). Primary outcome was MetS severity (MetS z-score). Secondary outcomes were body composition, muscle strength and quality of life (QoL). All groups significantly reduced body weight (similar to 3%) and fat mass (similar to 2.6 kg) but only 1-RT and 3-RT preserved skeletal muscle mass (SMM). All exercise groups increased muscle strength in major muscle groups (20-103%). However, only the two RT-groups improved MetS z-score (1-RT: -1.34, p = 0.003; 3-RT: -2.06, p < 0.001) and QoL (1-RT: +6%, p = 0.027; 3-RT: +12%, p < 0.001), while WB-EMS and CON had no impact on these outcomes. We conclude that traditional RT has superior effects on cardiometabolic health, SMM and QoL in obese MetS patients undergoing CR than WB-EMS.
C1 [Reljic, Dejan; Herrmann, Hans J.; Zopf, Yurdagul] Friedrich Alexander Univ Erlangen Nurnberg, Univ Hosp Erlangen, Dept Med 1, Hector Ctr Nutr Exercise & Sports, D-91054 Erlangen, Germany.
   [Reljic, Dejan; Herrmann, Hans J.; Neurath, Markus F.; Zopf, Yurdagul] Friedrich Alexander Univ Erlangen Nurnberg, Univ Hosp Erlangen, German Ctr Immunotherapy DZI, D-91054 Erlangen, Germany.
   [Neurath, Markus F.] Friedrich Alexander Univ Erlangen Nurnberg, Univ Hosp Erlangen, Dept Med 1, D-91054 Erlangen, Germany.
C3 University of Erlangen Nuremberg; University of Erlangen Nuremberg;
   University of Erlangen Nuremberg
RP Reljic, D (corresponding author), Friedrich Alexander Univ Erlangen Nurnberg, Univ Hosp Erlangen, Dept Med 1, Hector Ctr Nutr Exercise & Sports, D-91054 Erlangen, Germany.; Reljic, D (corresponding author), Friedrich Alexander Univ Erlangen Nurnberg, Univ Hosp Erlangen, German Ctr Immunotherapy DZI, D-91054 Erlangen, Germany.
EM dejan.reljic@uk-erlangen.de; hans.herrmann@uk-erlangen.de;
   markus.neurath@uk-erlangen.de; yurdaguel.zopf@uk-erlangen.de
RI Reljic, Dejan/CAG-1377-2022
OI Herrmann, Hans Joachim/0000-0002-3021-8022; Reljic,
   Dejan/0000-0001-8049-1775
FU H.W. & J. Hector Foundation; Manfred Roth Foundation; Research
   Foundation for Medicine at the University Hospital Erlangen
FX This study has been supported by the H.W. & J. Hector Foundation, the
   Manfred Roth Foundation, and Research Foundation for Medicine at the
   University Hospital Erlangen.
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NR 95
TC 15
Z9 15
U1 1
U2 5
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD MAY
PY 2021
VL 13
IS 5
AR 1640
DI 10.3390/nu13051640
PG 21
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA ST3KV
UT WOS:000662347800001
PM 34068089
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Jorge, JM
   Golas, A
   Patel, N
   Gonzalvo, JP
   Murr, MM
AF Jorge, Jay M.
   Golas, Adam
   Patel, Niketa
   Gonzalvo, John Paul
   Murr, Michel M.
TI Management of nonalcoholic fatty liver disease and the role of bariatric
   surgery: a brief review for surgeons
SO SURGERY FOR OBESITY AND RELATED DISEASES
LA English
DT Review
DE Liver fibrosis; Cirrhosis; Inflammation; Oxidative stress; Lipid
   metabolism; Lipogenesis; Fatty acid oxidation; Diabetes; Metabolic
   syndrome; Insulin resistance; Insulin sensitivity; Guidelines
ID Y GASTRIC BYPASS; ADVANCED FIBROSIS; OXIDATIVE STRESS; WEIGHT-LOSS;
   STEATOHEPATITIS; PLACEBO; INFLAMMATION; FEATURES; OUTCOMES; NAFLD
AB Nonalcoholic fatty liver disease (NAFLD) is closely linked to the metabolic syndrome and is highly prevalent in bariatric patients. The criterion standard to diagnose NAFLD is a liver biopsy specifically to detect inflammatory changes characteristic of nonalcoholic steatohepatitis. Technologic advancements will improve the accuracy of current noninvasive modalities. Modification of risk factors via food management is important to prevent the progression of NAFLD to nonalcoholic steatohepatitis and cirrhosis. Several clinical trials are underway for pharmacologic treatment of NAFLD; currently the mainstay of treatment is insulin sensitizers and vitamin E. There is strong evidence bariatric surgery improves biochemical and histologic features of NAFLD and therefore, bariatric surgery should be considered as a treatment of NAFLD in patients with obesity. Gastric bypass exhibits antilipogenic, antiinflammatory, antioxidant, and antidiabetic properties in the livers of laboratory animals; thereby, providing a unique window to study regulation of body adiposity and insulin resistance. (C) 2020 American Society for Bariatric Surgery. Published by Elsevier Inc. All rights reserved.
C1 [Jorge, Jay M.; Golas, Adam; Patel, Niketa; Gonzalvo, John Paul; Murr, Michel M.] AdventHlth Tampa, Bariatr & Metab Inst, 3000 Med Pk Dr,Suite 490, Tampa, FL 33613 USA.
C3 Adventist Health Services; AdventHealth; (AdventHealth) West Florida
   Division; West Florida Hospital; AdventHealth Tampa
RP Murr, MM (corresponding author), AdventHlth Tampa, Bariatr & Metab Inst, 3000 Med Pk Dr,Suite 490, Tampa, FL 33613 USA.
EM michel.murr@adventhealth.com
RI Patel, Niketa/HTN-6638-2023
OI Patel, Niketa A./0000-0003-4811-8596
CR Angulo P, 2007, HEPATOLOGY, V45, P846, DOI 10.1002/hep.21496
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NR 35
TC 4
Z9 4
U1 0
U2 5
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1550-7289
EI 1878-7533
J9 SURG OBES RELAT DIS
JI Surg. Obes. Relat. Dis.
PD MAY
PY 2020
VL 16
IS 5
BP 699
EP 703
DI 10.1016/j.soard.2020.01.028
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA LF4FG
UT WOS:000527374300019
PM 32151552
DA 2025-06-11
ER

PT J
AU Ramli, NZ
   Chin, KY
   Zarkasi, KA
   Ahmad, F
AF Ramli, Nur Zuliani
   Chin, Kok-Yong
   Zarkasi, Khairul Anwar
   Ahmad, Fairus
TI A Review on the Protective Effects of Honey against Metabolic Syndrome
SO NUTRIENTS
LA English
DT Review
DE honey; diabetes mellitus; dyslipidemia; hypertension; obesity
ID OBESITY-RELATED HYPERTENSION; CARDIOVASCULAR RISK-FACTORS; SUGAR-FREE
   DIET; NATURAL HONEY; BLOOD-PRESSURE; INSULIN-RESISTANCE;
   DIABETES-MELLITUS; OXIDATIVE STRESS; ADIPOSE-TISSUE; WEIGHT-GAIN
AB Metabolic syndrome (MetS) is a cluster of diseases comprising of obesity, diabetes mellitus, dyslipidemia, and hypertension. There are numerous pre-clinical as well as human studies reporting the protective effects of honey against MetS. Honey is a nutritional food low in glycemic index. Honey intake reduces blood sugar levels and prevents excessive weight gain. It also improves lipid metabolism by reducing total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL) and increasing high-density lipoprotein (HDL), which leads to decreased risk of atherogenesis. In addition, honey enhances insulin sensitivity that further stabilizes blood glucose levels and protects the pancreas from overstimulation brought on by insulin resistance. Furthermore, antioxidative properties of honey help in reducing oxidative stress, which is one of the central mechanisms in MetS. Lastly, honey protects the vasculature from endothelial dysfunction and remodelling. Therefore, there is a strong potential for honey supplementation to be integrated into the management of MetS, both as preventive as well as adjunct therapeutic agents.
C1 [Ramli, Nur Zuliani; Ahmad, Fairus] Univ Kebangsaan Malaysia, Dept Anat, UKM Med Ctr, Fac Med, Kuala Lumpur 56000, Malaysia.
   [Ramli, Nur Zuliani; Zarkasi, Khairul Anwar] Univ Malaysia Sabah, Dept Biomed Sci & Therapeut, Fac Med & Hlth Sci, Kota Kinabalu 88400, Sabah, Malaysia.
   [Chin, Kok-Yong] Univ Kebangsaan Malaysia, Dept Pharmacol, UKM Med Ctr, Fac Med, Kuala Lumpur 56000, Malaysia.
   [Zarkasi, Khairul Anwar] Univ Kebangsaan Malaysia, Dept Biochem, UKM Med Ctr, Fac Med, Kuala Lumpur 56000, Malaysia.
C3 Universiti Kebangsaan Malaysia; Universiti Malaysia Sabah; Universiti
   Kebangsaan Malaysia; Universiti Kebangsaan Malaysia
RP Ahmad, F (corresponding author), Univ Kebangsaan Malaysia, Dept Anat, UKM Med Ctr, Fac Med, Kuala Lumpur 56000, Malaysia.
EM nurzuliani@ums.edu.my; chinkokyong@ppukm.ukm.edu.my;
   khairul.anwar@ums.edu.my; fairusahmad@ukm.edu.my
RI Ramli, Nur Zuliani/AAB-3789-2021; Zarkasi, Khairul Anwar/HDN-0080-2022;
   Chin, Kok-Yong/B-6309-2015
OI Ahmad, Fairus/0000-0002-2452-6459; Chin, Kok-Yong/0000-0001-6628-1552;
   Ramli, Nur Zuliani/0000-0001-6700-3706; Zarkasi, Khairul
   Anwar/0000-0003-0766-6537
FU Universiti Kebangsaan Malaysia [FF-2017-446, GUP-2017-060]
FX This work was funded by grants FF-2017-446 and GUP-2017-060 from
   Universiti Kebangsaan Malaysia.
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NR 105
TC 51
Z9 55
U1 0
U2 30
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD AUG
PY 2018
VL 10
IS 8
AR 1009
DI 10.3390/nu10081009
PG 21
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA GU9PD
UT WOS:000445680200057
PM 30072671
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Marycz, K
   Weiss, C
   Smieszek, A
   Kornicka, K
AF Marycz, Krzysztof
   Weiss, Christine
   Smieszek, Agnieszka
   Kornicka, Katarzyna
TI Evaluation of Oxidative Stress and Mitophagy during Adipogenic
   Differentiation of Adipose-Derived Stem Cells Isolated from Equine
   Metabolic Syndrome (EMS) Horses
SO STEM CELLS INTERNATIONAL
LA English
DT Article
ID INSULIN-RESISTANCE; TISSUE; AUTOPHAGY; EXPRESSION; RECEPTOR; GENES;
   ALPHA; LIVER; IL-6
AB Mesenchymal stem cells (MSCs) are frequently used in both human and veterinary medicine because their unique properties, such as modulating the immune response and differentiating into multiple lineages, make them a valuable tool in cell-based therapies. However, many studies have indicated the age-, lifestyle-, and disease-related deterioration of MSC regenerative characteristics. However, it still needs to be elucidated how the patient's health status affects the effectiveness of MSC differentiation. In the present study, we isolated mesenchymal stem cells from adipose tissue (adipose-derived mesenchymal stem cells (ASCs)) from horses diagnosed with equine metabolic syndrome (EMS), a common metabolic disorder characterized by pathological obesity and insulin resistance. We investigated the metabolic status of isolated cells during adipogenic differentiation using multiple research methods, such as flow cytometry, PCR, immunofluorescence, or transmission and confocal microscopy. The results indicated the impaired differentiation potential of ASCEMS. Excessive ROS accumulation and ER stress are most likely the major factors limiting the multipotency of these cells. However, we observed autophagic flux during differentiation as a protective mechanism that allows cells to maintain homeostasis and remove dysfunctional mitochondria.
C1 [Marycz, Krzysztof; Smieszek, Agnieszka; Kornicka, Katarzyna] Wroclaw Univ Environm & Life Sci, Fac Biol & Anim Sci, Dept Expt, Norwida 25, PL-50375 Wroclaw, Poland.
   [Marycz, Krzysztof] Wroclaw Res Ctr EIT, Stablowicka 147, PL-54066 Wroclaw, Poland.
   [Weiss, Christine] PferdePraxis Dr Med Vet Daniel Weiss, Postmatte 14, CH-8807 Freienbach, Switzerland.
C3 Wroclaw University of Environmental & Life Sciences
RP Marycz, K (corresponding author), Wroclaw Univ Environm & Life Sci, Fac Biol & Anim Sci, Dept Expt, Norwida 25, PL-50375 Wroclaw, Poland.
EM krzysztof.marycz@upwr.edu.pl
RI Smieszek, Agnieszka/A-4887-2017
OI Smieszek, Agnieszka/0000-0002-7314-9821
FU National Science Centre, Poland [2016/21/B/NZ7/01111]; Wroclaw Centre of
   Biotechnology programme from the Leading National Research Centre (KNOW)
FX This research was supported by the National Science Centre, Poland
   through Grant no. 2016/21/B/NZ7/01111 "Modulation mitochondrial
   metabolism and dynamics and targeting DNA methylation of adipose-derived
   mesenchymal stromal stem cell (ASC) using resveratrol and 5-azacytydin
   as a therapeutic strategy in the course of equine metabolic syndrome
   (EMS)." This publication was supported by the Wroclaw Centre of
   Biotechnology programme from the Leading National Research Centre (KNOW)
   for years 2014-2018.
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NR 43
TC 38
Z9 38
U1 0
U2 4
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1687-966X
EI 1687-9678
J9 STEM CELLS INT
JI Stem Cells Int.
PY 2018
VL 2018
AR 5340756
DI 10.1155/2018/5340756
PG 18
WC Cell & Tissue Engineering
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA GK0XY
UT WOS:000435837000001
PM 29977307
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Manojlovic-Stojanoski, M
   Nestorovic, N
   Petkovic, B
   Balind, SR
   Ristic, N
   Trifunovic, S
   Ajdzanovic, V
   Filipovic, B
   Sosic-Jurjevic, B
   Milosevic, V
AF Manojlovic-Stojanoski, Milica
   Nestorovic, Natasa
   Petkovic, Branka
   Balind, Snezana Raus
   Ristic, Natasa
   Trifunovic, Svetlana
   Ajdzanovic, Vladimir
   Filipovic, Branko
   Sosic-Jurjevic, Branka
   Milosevic, Verica
TI The effects of prenatal dexamethasone exposure and fructose challenge on
   pituitary-adrenocortical activity and anxiety-like behavior in female
   offspring
SO TISSUE & CELL
LA English
DT Article
DE Adrenal gland; Stereology; Programming; Dexamethasone; Fructose
ID ENDOTHELIAL GROWTH-FACTOR; GLUCOCORTICOID TREATMENT; METABOLIC SYNDROME;
   DIET; EXPRESSION; DECREASES; SECRETION; TISSUE; MICE; RAT
AB Prenatal glucocorticoid overexposure could largely influence pituitary-adrenal activity and anxiety-like behavior in offspring. Our aim was to study the possible potentiating effect of moderate dose of fructose - common ingredient of today's diet - on prenatal glucocorticoid treatment-induced hypothalamo-pituitary-adrenal (HPA) axis changes. Pregnant female rats were treated with multiple dexamethasone (Dx) doses (3 x 0.5 mg/kg/b.m. Dx; 16th-18th gestational day). Half of female offspring from control and Dx treated dams were supplemented with 10% fructose solution, from weaning fill adulthood. Immunohistochemistry, unbiased stereological evaluation and hormonal analysis are used to provide the morpho-functional state of pituitary and adrenal gland. Anxiety-like behavior was assessed using the light/dark box WA and the elevated plus maze test. Prenatally Dx exposed females, with or without fructose consumption, had markedly reduced adrenocortical volume (p < 0.05) comparing to controls. Increased basal plasma ACTH level in these females (p < 0.05) maintained corticosterone concentration at control level produced by smaller adrenal glands. In parallel, anxiety-like behavior was shown by both tests used. In conclusion, prenatal Dx exposure cause negative psychophysiological outcome reflected in increased HPA axis activity and anxiety behavior in female offspring, while moderately increased fructose consumption failed to evoke any alteration or to potentiate effects of prenatal Dx exposure.
C1 [Manojlovic-Stojanoski, Milica; Nestorovic, Natasa; Petkovic, Branka; Balind, Snezana Raus; Ristic, Natasa; Trifunovic, Svetlana; Ajdzanovic, Vladimir; Filipovic, Branko; Sosic-Jurjevic, Branka; Milosevic, Verica] Univ Belgrade, Inst Biol Res Sinisa Stankovic, Natl Inst Republ Serbia, 142 Despota Stefana Blvd, Belgrade 11060, Serbia.
C3 University of Belgrade
RP Manojlovic-Stojanoski, M (corresponding author), Univ Belgrade, Inst Biol Res Sinisa Stankovic, Natl Inst Republ Serbia, 142 Despota Stefana Blvd, Belgrade 11060, Serbia.
EM manojlo@ibiss.bg.ac.rs
RI Dinic, Svetlana/C-8348-2017; Ristić, Nataša/O-8974-2016; Nestorovic,
   Natasa/C-6412-2016; Manojlovic-Stojanoski, Milica/JNS-5001-2023;
   Sosic-Jurjevic, Branka/AHD-4810-2022; Petkovic, Branka/GNH-5614-2022
OI Raus Balind, Snezana/0000-0003-1657-4677; Nestorovic,
   Natasa/0000-0001-6218-988X; Ajdzanovic, Vladimir/0000-0002-6540-9603; ,
   Svetlana/0000-0002-9141-5732; Filipovic, Branko/0000-0001-5352-763X;
   Manojlovic-Stojanoski, Milica/0000-0003-0511-8799; Sosic-Jurjevic,
   Branka/0000-0002-5496-0619; Petkovic, Branka/0000-0001-7817-4092
FU Ministry of Education and Technological Development [173009]
FX This work was supported by the Ministry of Education and Technological
   Development, Grant number 173009. The Ministry's involvement was only of
   financial nature.
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NR 41
TC 3
Z9 3
U1 0
U2 1
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0040-8166
J9 TISSUE CELL
JI Tissue Cell
PD FEB
PY 2020
VL 62
AR 101309
DI 10.1016/j.tice.2019.101309
PG 10
WC Anatomy & Morphology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Anatomy & Morphology; Cell Biology
GA KE9TC
UT WOS:000508892200006
PM 32433017
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Rodríguez-Fierros, FL
   Guarner-Lans, V
   Soto, ME
   Manzano-Pech, L
   Díaz-Díaz, E
   Soria-Castro, E
   Rubio-Ruiz, ME
   Jiménez-Trejo, F
   Pérez-Torres, I
AF Rodriguez-Fierros, Felix Leao
   Guarner-Lans, Veronica
   Soto, Maria Elena
   Manzano-Pech, Linaloe
   Diaz-Diaz, Eulises
   Soria-Castro, Elizabeth
   Rubio-Ruiz, Maria Esther
   Jimenez-Trejo, Francisco
   Perez-Torres, Israel
TI Modulation of Renal Function in a Metabolic Syndrome Rat Model by
   Antioxidants in Hibiscus sabdariffa L.
SO MOLECULES
LA English
DT Article
DE metabolic syndrome; Hibiscus sabdariffa L; oxidative stress; kidney;
   renal function
AB Metabolic syndrome (MS) is the association of three or more pathologies among which obesity, hypertension, insulin resistance, dyslipidemia, and diabetes are included. It causes oxidative stress (OS) and renal dysfunction. Hibiscus sabdariffa L. (HSL) is a source of natural antioxidants that may control the renal damage caused by the MS. The objective of this work was to evaluate the effect of a 2% HSL infusion on renal function in a MS rat model induced by the administration of 30% sucrose in drinking water. 24 male Wistar rats were divided into 3 groups: Control rats, MS rats and MS + HSL rats. MS rats had increased body weight, systolic blood pressure, triglycerides, insulin, HOMA index, and leptin (p <= 0.04). Renal function was impaired by an increase in perfusion pressure in the isolated and perfused kidney, albuminuria (p <= 0.03), and by a decrease in clearance of creatinine (p <= 0.04). The activity of some antioxidant enzymes including the superoxide dismutase isoforms, peroxidases, glutathione peroxidase, glutathione-S-transferase was decreased (p <= 0.05). Lipoperoxidation and carbonylation were increased (p <= 0.001). The nitrates/nitrites ratio, total antioxidant capacity, glutathione levels and vitamin C were decreased (p <= 0.03). The treatment with 2% HSL reversed these alterations. The results suggest that the treatment with 2% HSL infusion protects renal function through its natural antioxidants which favor an improved renal vascular response. The infusion contributes to the increase in the glomerular filtration rate, by promoting an increase in the enzymatic and non-enzymatic antioxidant systems leading to a decrease in OS and reestablishing the normal renal function.
C1 [Rodriguez-Fierros, Felix Leao; Manzano-Pech, Linaloe; Soria-Castro, Elizabeth; Perez-Torres, Israel] Inst Nacl Cardiol Ignacio Chavez, Dept Cardiovasc Biomed, Juan Badiano 1,Secc XVI, Mexico City 14080, DF, Mexico.
   [Guarner-Lans, Veronica; Rubio-Ruiz, Maria Esther] Inst Nacl Cardiol Ignacio Chavez, Dept Physiol, Juan Badiano 1,Secc XVI, Mexico City 14080, DF, Mexico.
   [Soto, Maria Elena] Inst Nacl Cardiol Ignacio Chavez, Dept Immunol, Juan Badiano 1,Secc XVI, Mexico City 14080, DF, Mexico.
   [Diaz-Diaz, Eulises] Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Reprod Biol, Vasco de Quiroga 15,Secc XVI, Mexico City 14000, DF, Mexico.
   [Jimenez-Trejo, Francisco] Inst Nacl Pediat, Dept Reprod Biol, Insurgentes Sur 3700-C, Mexico City 04530, DF, Mexico.
C3 National Institute of Cardiology - Mexico; National Institute of
   Cardiology - Mexico; National Institute of Cardiology - Mexico;
   Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran -
   Mexico
RP Pérez-Torres, I (corresponding author), Inst Nacl Cardiol Ignacio Chavez, Dept Cardiovasc Biomed, Juan Badiano 1,Secc XVI, Mexico City 14080, DF, Mexico.
EM felixleao@hotmail.com; gualanv@yahoo.com; mesoto50@hotmail.com;
   loe_mana@hotmail.com; eulisesd@yahoo.com; elizabethsoria824@gmail.com;
   esther_rubio_ruiz@yahoo.com; trejofj@hotmail.com;
   israel.perez@cardiologia.org.mx
RI Pérez Torres, Israel/AAE-2579-2022; Guarner-Lans, Verónica/AFW-3723-2022
OI Soto, Maria Elena/0000-0003-1332-2888; Perez-Torres,
   Israel/0000-0001-6510-2954; Guarner-Lans, Veronica/0000-0002-2655-7590;
   Rubio-Ruiz, Maria Esther/0000-0002-8844-2078
FU Postgraduate Section in the Program of Maestria y Doctorado en Ciencias
   de la Produccion y de la Salud Animal of the UNAM
FX We thank the Postgraduate Section in the Program of Maestria y Doctorado
   en Ciencias de la Produccion y de la Salud Animal of the UNAM for a
   scholarship to Felix Leao Rodriguez-Fierros. We thank Benito Chavez
   Renteria for histology technical support.
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NR 68
TC 16
Z9 16
U1 0
U2 7
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1420-3049
J9 MOLECULES
JI Molecules
PD APR
PY 2021
VL 26
IS 7
AR 2074
DI 10.3390/molecules26072074
PG 20
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA RL1IA
UT WOS:000638734500001
PM 33916540
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Lucena, S
   Coelho, AV
   Anjo, SI
   Manadas, B
   Mrljak, V
   Silva, FCE
   Lamy, E
   Tvarijonaviciute, A
AF Lucena, Sonia
   Coelho, Ana Varela
   Anjo, Sandra I.
   Manadas, Bruno
   Mrljak, Vladimir
   Capela e Silva, Fernando
   Lamy, Elsa
   Tvarijonaviciute, Asta
TI Comparative proteomic analysis of saliva from dogs with and without
   obesity-related metabolic dysfuntion
SO JOURNAL OF PROTEOMICS
LA English
DT Article
DE Dog; Saliva; Proteome; Obesity; Metabolic syndrome
ID OXIDATIVE STRESS; INSULIN-RESISTANCE; SERUM; CYTOKINES; PROFILE
AB Dogs develop only some of the components of the human metabolic syndrome (MetS). Thus, in order to study possible MetS-related alterations in dogs, human MetS criteria were adapted to define canine MetS or so-called obesity-related metabolic dysfunction (ORMD). The main objective of this study was to identify changes in the salivary proteome of obese dogs with ORMD in comparison with obese dogs without ORMD which may constitute potential salivary biomarkers for assessing ORMD. In a first phase, 12 adult obese dogs with ORMD (N = 6) and without ORMD (N = 6) were included in the study. Subsequently, and with the aim of validating and strengthening the results, additional 12 obese dogs (6 with and 6 without ORMD) were tested in an independent experiment following the same protocol. Saliva samples were subjected to a quantitative proteomics analysis and the levels of nine salivary proteins were found to be significantly different between groups, among them those which had greatest fold-change were proteins involved in glycolysis and oxidative stress. In conclusion, despite metabolic syndrome to include different combinations of diseases, the observation of differences in salivary proteome suggests a potential of this fluid to understand the pathophysiology of the disease.
   Significance: This is the first study evaluating proteomes of saliva in dogs, as a non invasive sample, in order to increase knowledge about the metabolic/physiopathological changes related to obesity-related metabolic dysfunction (ORMD) together with the identification of potential biomarkers for its diagnosis. As approximately 20% of dogs with naturally occurring obesity were described to suffer ORMD associated with insulin resistance and hypoadiponectinemia, the fact that indicate possible links between ORMD and associated diseases.
C1 [Lucena, Sonia; Capela e Silva, Fernando; Lamy, Elsa] Univ Evora, Inst Agr & Environm Environm Sci ICAAM, Evora, Portugal.
   [Lucena, Sonia] Univ Evora, Sch Sci & Technol, Dept Vet Med, Evora, Portugal.
   [Coelho, Ana Varela] Univ Nova Lisboa, Inst Chem & Biol Technol ITQB, Lisbon, Portugal.
   [Anjo, Sandra I.; Manadas, Bruno] Univ Coimbra, CNC Ctr Neurosci & Cell Biol, Coimbra, Portugal.
   [Anjo, Sandra I.] Univ Coimbra, Fac Med, Coimbra, Portugal.
   [Mrljak, Vladimir] Univ Zagreb, Fac Vet Med, Clin Internal Dieaases, Heinzelova 55, Zagreb 10000, Croatia.
   [Capela e Silva, Fernando] Univ Evora, Sch Sci & Technol, Dept Biol, Evora, Portugal.
   [Tvarijonaviciute, Asta] Univ Murcia, Interlab UMU, Reg Campus Int Excellence, Campus Mare Nostrum, Ed 16,4a Pl,Campus Espinardo, E-30100 Murcia, Spain.
C3 University of Evora; University of Evora; Universidade Nova de Lisboa;
   Universidade de Coimbra; Universidade de Coimbra; University of Zagreb;
   University of Evora; University of Murcia
RP Tvarijonaviciute, A (corresponding author), Univ Murcia, Interlab UMU, Reg Campus Int Excellence, Campus Mare Nostrum, Ed 16,4a Pl,Campus Espinardo, E-30100 Murcia, Spain.
EM asta@um.es
RI Manadas, Bruno/A-7667-2012; Capela e Silva, Fernando/L-3261-2014;
   Coelho, Ana/H-8885-2012; Tvarijonaviciute, Asta/U-4303-2017; Anjo,
   Sandra/P-4479-2015; Lamy, Elsa/L-2309-2014
OI Manadas, Bruno/0000-0002-2087-4042; Coelho, Ana/0000-0002-6143-4203;
   Tvarijonaviciute, Asta/0000-0002-5323-5001; Mrljak,
   Vladimir/0000-0002-0723-7815; Anjo, Sandra/0000-0003-2180-3518; Lucena,
   Sonia/0000-0002-0607-5295; Lamy, Elsa/0000-0002-9370-1337
FU national funding through Portuguese Science Foundation (FCT)
   [UID/AGR/00115/2013]; Robles Chillida Foundation through its support
   program for the promotion on research in Health Sciences; European
   Regional Development Fund (ERDF) through the COMPETE 2020 - Operational
   Programme for Competitiveness and Internationalisation and Portuguese
   national funds via FCT [POCI-01-0145-FEDER-029311,
   POCI-01-0145-FEDER-007440, UID/NEU/04539/2013,
   POCI-01-0145-FEDER-016428, SAICTPAC/0010/2015,
   POCI-01-0145-FEDER-016795, PTDC/NEU-SCC/7051/2014]; National Mass
   Spectrometry Network (RNEM) [POCI-01-0145-FEDER-402-022125,
   ROTEIRO/0028/2013]; FCT [IF/01778/2013]; program "Juan de la Cierva
   Incorporacion" of `Ministerio de Economia y Competitividad', Spain
FX This paper was funded by national funding through Portuguese Science
   Foundation (FCT) under the project UID/AGR/00115/2013 (ICAAM -University
   of Evora) and by a grant from the Robles Chillida Foundation through its
   support program for the promotion on research in Health Sciences. This
   work was also financed by the European Regional Development Fund (ERDF)
   through the COMPETE 2020 - Operational Programme for Competitiveness and
   Internationalisation and Portuguese national funds via FCT, under
   projects: POCI-01-0145-FEDER-029311; POCI-01-0145-FEDER-007440 (ref.;
   UID/NEU/04539/2013), POCI-01-0145-FEDER-016428 (ref.:
   SAICTPAC/0010/2015), and POCI-01-0145-FEDER-016795 (ref.:
   PTDC/NEU-SCC/7051/2014); and by The National Mass Spectrometry Network
   (RNEM) under the contract POCI-01-0145-FEDER-402-022125 (ref.:
   ROTEIRO/0028/2013). The authors also had financial support from FCT in
   the form of Elsa Lamy's FCT investigator contract IF/01778/2013. Asta
   Tvarijonaviciute was supported by the program "Juan de la Cierva
   Incorporacion" of `Ministerio de Economia y Competitividad', Spain,
   through a postdoctoral grant. Funders had no role in study design, data
   collection, analysis, interpretation, or writing of the report.
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NR 36
TC 12
Z9 12
U1 0
U2 14
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1874-3919
EI 1876-7737
J9 J PROTEOMICS
JI J. Proteomics
PD JUN 15
PY 2019
VL 201
BP 65
EP 72
DI 10.1016/j.jprot.2019.04.010
PG 8
WC Biochemical Research Methods
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA HZ9ED
UT WOS:000469157700007
PM 30991157
OA Green Published
DA 2025-06-11
ER

PT J
AU Regnault, C
   Usal, M
   Veyrenc, S
   Couturier, K
   Batandier, C
   Bulteau, AL
   Lejon, D
   Sapin, A
   Combourieu, B
   Chetiveaux, M
   Le May, C
   Lafond, T
   Raveton, M
   Reynaud, S
AF Regnault, Christophe
   Usal, Marie
   Veyrenc, Sylvie
   Couturier, Karine
   Batandier, Cecile
   Bulteau, Anne-Laure
   Lejon, David
   Sapin, Alexandre
   Combourieu, Bruno
   Chetiveaux, Maud
   Le May, Cedric
   Lafond, Thomas
   Raveton, Muriel
   Reynaud, Stephane
TI Unexpected metabolic disorders induced by endocrine disruptors in
   Xenopus tropicalis provide new lead for understanding amphibian
   decline
SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF
   AMERICA
LA English
DT Article
DE endocrine disruptors; metabolic syndrome; transgenerational; amphibian
   population decline; Xenopus tropicalis
ID NONALCOHOLIC FATTY LIVER; BISPHENOL-A EXPOSURE; ENDOPLASMIC-RETICULUM
   STRESS; THYROID-HORMONE; INSULIN-RESISTANCE; NUCLEAR RECEPTORS;
   AROMATASE EXPRESSION; METAMORPHOSIS ASSAY; HERBICIDE ATRAZINE;
   GLUCOSE-METABOLISM
AB Despite numerous studies suggesting that amphibians are highly sensitive to endocrine disruptors (EDs), both their role in the decline of populations and the underlying mechanisms remain unclear. This study showed that frogs exposed throughout their life cycle to ED concentrations low enough to be considered safe for drinking water, developed a prediabetes phenotype and, more commonly, a metabolic syndrome. Female Xenopus tropicalis exposed from tadpole stage to benzo(a) pyrene or triclosan at concentrations of 50 ng.L-1 displayed glucose intolerance syndrome, liver steatosis, liver mitochondrial dysfunction, liver transcriptomic signature, and pancreatic insulin hypersecretion, all typical of a prediabetes state. This metabolic syndrome led to progeny whose metamorphosis was delayed and occurred while the individuals were both smaller and lighter, all factors that have been linked to reduced adult recruitment and likelihood of reproduction. We found that F-1 animals did indeed have reduced reproductive success, demonstrating a lower fitness in ED-exposed Xenopus. Moreover, after 1 year of depuration, Xenopus that had been exposed to benzo(a) pyrene still displayed hepatic disorders and a marked insulin secretory defect resulting in glucose intolerance. Our results demonstrate that amphibians are highly sensitive to EDs at concentrations well below the thresholds reported to induce stress in other vertebrates. This study introduces EDs as a possible key contributing factor to amphibian population decline through metabolism disruption. Overall, our results show that EDs cause metabolic disorders, which is in agreement with epidemiological studies suggesting that environmental EDs might be one of the principal causes of metabolic disease in humans.
C1 [Regnault, Christophe; Usal, Marie; Veyrenc, Sylvie; Raveton, Muriel; Reynaud, Stephane] Univ Savoie Mt Blanc, Univ Grenoble Alpes, CNRS, LECA, F-38000 Grenoble, France.
   [Couturier, Karine; Batandier, Cecile] Univ Grenoble Alpes, INSERM, LBFA, F-38000 Grenoble, France.
   [Bulteau, Anne-Laure] Univ Lyon 1, Inst Genom Fonct Lyon, CNRS, UMR 5242,Ecole Normale Super Lyon, F-69000 Lyon, France.
   [Lejon, David; Sapin, Alexandre; Combourieu, Bruno] Rovaltain Res Co, F-26300 Alixan, France.
   [Chetiveaux, Maud; Le May, Cedric] Univ Nantes, Plate Forme Therassay, Inst Thorax, INSERM,CNRS, F-44007 Nantes, France.
   [Lafond, Thomas] Univ Rennes 1, Ctr Ressources Biol Xenopes, CNRS, Unite Mixte Serv 3387, F-35042 Rennes, France.
C3 Universite Savoie Mont Blanc; Communaute Universite Grenoble Alpes;
   Universite Grenoble Alpes (UGA); Centre National de la Recherche
   Scientifique (CNRS); Communaute Universite Grenoble Alpes; Universite
   Grenoble Alpes (UGA); Institut National de la Sante et de la Recherche
   Medicale (Inserm); Centre National de la Recherche Scientifique (CNRS);
   CNRS - National Institute for Biology (INSB); CHU Lyon; Ecole Normale
   Superieure de Lyon (ENS de LYON); Universite Claude Bernard Lyon 1;
   Institut National de la Sante et de la Recherche Medicale (Inserm);
   Nantes Universite; CHU de Nantes; Centre National de la Recherche
   Scientifique (CNRS); Universite de Rennes; Centre National de la
   Recherche Scientifique (CNRS)
RP Reynaud, S (corresponding author), Univ Savoie Mt Blanc, Univ Grenoble Alpes, CNRS, LECA, F-38000 Grenoble, France.
EM stephane.reynaud@univ-grenoble-alpes.fr
RI Le May, cedric/D-2691-2009; bulteau, anne-laure/AAN-4004-2020; Raveton,
   Muriel/K-1403-2013; Reynaud, Stephane/H-5493-2013
OI Reynaud, Stephane/0000-0003-0248-0602; veyrenc,
   sylvie/0000-0003-2894-3820
FU Communaute d'Universites et Etablissements Universite Grenoble-Alpes
   Initiatives de Recherche Strategiques Initiatives d'Excellence Grant;
   Federative Structure Environnemental and Systems Biology (BEeSy) of the
   Grenoble-Alpes University; French Ministry of Higher Education and
   Research; Region Auvergne-Rhone-Alpes
FX We thank Kim Barrett (Version Originale) and Oliver Ross
   (XpertScientific) for the English review of the revised manuscript. This
   work was funded by Communaute d'Universites et Etablissements Universite
   Grenoble-Alpes Initiatives de Recherche Strategiques Initiatives
   d'Excellence Grant and by the Federative Structure Environnemental and
   Systems Biology (BEeSy) of the Grenoble-Alpes University. C.R. received
   funding from the French Ministry of Higher Education and Research. M.U.
   was funded by the Region Auvergne-Rhone-Alpes.
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NR 87
TC 46
Z9 52
U1 1
U2 58
PU NATL ACAD SCIENCES
PI WASHINGTON
PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA
SN 0027-8424
J9 P NATL ACAD SCI USA
JI Proc. Natl. Acad. Sci. U. S. A.
PD MAY 8
PY 2018
VL 115
IS 19
BP E4416
EP E4425
DI 10.1073/pnas.1721267115
PG 10
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA GF0RQ
UT WOS:000431639100015
PM 29686083
OA Green Submitted, Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Belli, AA
   Gok, SO
   Akbaba, G
   Etgu, F
   Dogan, G
AF Akin Belli, Asli
   Ozbas Gok, Seyran
   Akbaba, Gulhan
   Etgu, Fatma
   Dogan, Gursoy
TI The relationship between rosacea and insulin resistance and metabolic
   syndrome
SO EUROPEAN JOURNAL OF DERMATOLOGY
LA English
DT Article
DE cardiovascular diseases; insulin resistance; metabolic syndrome; rosacea
ID ENDOPLASMIC-RETICULUM STRESS; CARDIOVASCULAR RISK-FACTORS; PEPTIDE
   LL-37; ER STRESS; INFLAMMASOME; PATHOGENESIS; ACTIVATION
AB Background: Rosacea is a chronic inflammatory skin disease affecting the face. A positive correlation has been found between rosacea and cardiovascular diseases. Objectives: We sought to investigate the relation between rosacea and metabolic syndrome (MS) and insulin resistance (IR). Materials and methods: Between January and June 2015, a case-control study including 47 age-, gender-, and body mass index (BMI)-matched rosacea patients and 50 controls was conducted. Demographic data, clinical features of rosacea patients, anthropometric measures, laboratory findings, blood pressure levels, BMI, smoking history, alcohol consumption, sports life, family history of cardiovascular disease, and presence of MS and IR were recorded. Results: Forty-seven rosacea patients (12 men and 35 women; age range: 35-68 years) and 50 controls (11 men and 39 women; age range: 38-78 years) were included in our study. Of 47 rosacea patients, 24 had erythematotelangiectatic type, 22 had papulopustular type, and one had phymatous type. Whereas the rate of IR was significantly higher in the rosacea group, there was no significant difference in the rate of MS between rosacea and the control group (p = 0.009 and p = 0.186, respectively). In addition, the rosacea group had significantly higher fasting blood glucose, total cholesterol, and systolic and diastolic blood pressure levels (p < 0.05). Mean levels of LDL, triglyceride, total cholesterol and CRP were significantly higher than in the control group (p < 0.05). Conclusion: Our findings suggest that there is a relationship between rosacea and IR and some parameters of cardiovascular risk factors. We recommend investigation of IR in rosacea patients.
C1 [Akin Belli, Asli; Dogan, Gursoy] Kocman Univ Training & Res Hosp, Dept Dermatol, Mugla, Turkey.
   [Ozbas Gok, Seyran] Artvin Hopa State Hosp, Dept Dermatol, Artvin, Turkey.
   [Akbaba, Gulhan] Mugla Sitki Kocman Univ Training & Res Hosp, Dept Endocrinol & Metab Dis, Mugla, Turkey.
   [Etgu, Fatma] Ardahan State Hosp, Dept Dermatol, Ardahan, Turkey.
C3 Artvin State Hospital; Hopa State Hospital; Ardahan State Hospital
RP Belli, AA (corresponding author), Kocman Univ Training & Res Hosp, Dept Dermatol, Mugla, Turkey.
EM dr_asliakin@hotmail.com
OI Etgu, Fatma/0000-0003-1214-3327
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NR 28
TC 56
Z9 57
U1 0
U2 13
PU JOHN LIBBEY EUROTEXT LTD
PI MONTROUGE
PA 127 AVE DE LA REPUBLIQUE, 92120 MONTROUGE, FRANCE
SN 1167-1122
EI 1952-4013
J9 EUR J DERMATOL
JI Eur. J. Dermatol.
PD MAY-JUN
PY 2016
VL 26
IS 3
BP 260
EP 264
DI 10.1684/ejd.2016.2748
PG 5
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA DP8YC
UT WOS:000378782900006
PM 27328660
DA 2025-06-11
ER

PT J
AU Radosavljevic, T
   Brankovic, M
   Samardzic, J
   Djuretic, J
   Vukicevic, D
   Vucevic, D
   Jakovljevic, V
AF Radosavljevic, Tatjana
   Brankovic, Milica
   Samardzic, Janko
   Djuretic, Jasmina
   Vukicevic, Dusan
   Vucevic, Danijela
   Jakovljevic, Vladimir
TI Altered Mitochondrial Function in MASLD: Key Features and Promising
   Therapeutic Approaches
SO ANTIOXIDANTS
LA English
DT Review
DE mitochondria; MASLD; MASH; mitochondrial dysfunction; metabolic
   syndrome; oxidative stress; mitochondrial quality control
ID STEATOTIC LIVER-DISEASE; TARGETED ANTIOXIDANT; LIPID-METABOLISM; HEPATIC
   STEATOSIS; CONTROLLED-TRIAL; MITO-TEMPO; DYSFUNCTION; MITOPHAGY; MICE;
   MECHANISMS
AB Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as nonalcoholic fatty liver disease (NAFLD), encompasses a range of liver conditions from steatosis to nonalcoholic steatohepatitis (NASH). Its prevalence, especially among patients with metabolic syndrome, highlights its growing global impact. The pathogenesis of MASLD involves metabolic dysregulation, inflammation, oxidative stress, genetic factors and, notably, mitochondrial dysfunction. Recent studies underscore the critical role of mitochondrial dysfunction in MASLD's progression. Therapeutically, enhancing mitochondrial function has gained interest, along with lifestyle changes and pharmacological interventions targeting mitochondrial processes. The FDA's approval of resmetirom for metabolic-associated steatohepatitis (MASH) with fibrosis marks a significant step. While resmetirom represents progress, further research is essential to understand MASLD-related mitochondrial dysfunction fully. Innovative strategies like gene editing and small-molecule modulators, alongside lifestyle interventions, can potentially improve MASLD treatment. Drug repurposing and new targets will advance MASLD therapy, addressing its increasing global burden. Therefore, this review aims to provide a better understanding of the role of mitochondrial dysfunction in MASLD and identify more effective preventive and treatment strategies.
C1 [Radosavljevic, Tatjana; Vucevic, Danijela] Univ Belgrade, Inst Pathophysiol Ljubodrag Buba Mihailovic, Fac Med, Belgrade 11000, Serbia.
   [Brankovic, Milica; Samardzic, Janko] Univ Belgrade, Inst Pharmacol Clin Pharmacol & Toxicol, Fac Med, Belgrade 11000, Serbia.
   [Djuretic, Jasmina] Univ Belgrade, Fac Pharm, Dept Pathobiol, Belgrade 11000, Serbia.
   [Vukicevic, Dusan] Uniklin Mannheim, Theodor Kutyer Ufer 1-3, D-68167 Mannheim, Germany.
   [Jakovljevic, Vladimir] Univ Kragujevac, Fac Med Sci, Dept Physiol, Svetozara Markovica 69, Kragujevac 34000, Serbia.
   [Jakovljevic, Vladimir] Univ Kragujevac, Ctr Excellence Study Redox Balance Cardiovasc & Me, Svetozara Markovica 69, Kragujevac 34000, Serbia.
   [Jakovljevic, Vladimir] First Moscow State Med Univ IM Sechenov, Dept Human Pathol, Trubetskaya St 8, Str 2, Moscow 119991, Russia.
C3 University of Belgrade; University of Belgrade; University of Belgrade;
   Ruprecht Karls University Heidelberg; University of Kragujevac;
   University of Kragujevac; Sechenov First Moscow State Medical University
RP Radosavljevic, T (corresponding author), Univ Belgrade, Inst Pathophysiol Ljubodrag Buba Mihailovic, Fac Med, Belgrade 11000, Serbia.
EM tatjana.radosavljevic@med.bg.ac.rs; milicabrankovic137@yahoo.com;
   jankomedico@yahoo.es; jasmina.djuretic@pharmacy.bg.ac.rs;
   vukdusan@hotmail.com; danijela.vucevic@med.bg.ac.rs;
   drvladakgbg@gmail.com
RI Radosavljević, Tatjana/AAE-2792-2020; Samardzic, Janko/H-7897-2019
OI Samardzic, Janko/0000-0002-8464-4924; Djuretic,
   Jasmina/0000-0002-8457-4962; Radosavljevic, Tatjana/0000-0002-1701-3313
FU Faculty of Medical Sciences, University of Kragujevac [JP 27/20];
   Ministry of Science, Technical Development, and Innovation of the
   Republic of Serbia [451-03-47/2023-01/200111, 451-03-66/2024-03/200110,
   451-03-65/2024-03/200161, 451-03-66/2024-03/200161]
FX This research was supported by the Faculty of Medical Sciences,
   University of Kragujevac (JP 27/20) and the Ministry of Science,
   Technical Development, and Innovation of the Republic of Serbia through
   Grant Agreements Nos. 451-03-47/2023-01/200111,
   451-03-66/2024-03/200110, 451-03-65/2024-03/200161, and
   451-03-66/2024-03/200161.
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NR 157
TC 11
Z9 11
U1 13
U2 15
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD AUG
PY 2024
VL 13
IS 8
AR 906
DI 10.3390/antiox13080906
PG 18
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA E8V3I
UT WOS:001305716300001
PM 39199152
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Colle, R
   de Larminat, D
   Rotenberg, S
   Hozer, F
   Hardy, P
   Verstuyft, C
   Fève, B
   Corruble, E
AF Colle, R.
   de Larminat, D.
   Rotenberg, S.
   Hozer, F.
   Hardy, P.
   Verstuyft, C.
   Feve, B.
   Corruble, E.
TI PPAR-γ Agonists for the Treatment of Major Depression: A Review
SO PHARMACOPSYCHIATRY
LA English
DT Review
DE major depression; PPAR-gamma agonists; pioglitazone; efficacy; safety
ID TYPE-2 DIABETES-MELLITUS; PROLIFERATOR-ACTIVATED RECEPTORS; PIOGLITAZONE
   ADJUNCTIVE THERAPY; METABOLIC SYNDROME; DOUBLE-BLIND; MACROVASCULAR
   EVENTS; BIPOLAR DISORDER; CLINICAL-TRIAL; METAANALYSIS;
   THIAZOLIDINEDIONES
AB Introduction Selective agonists of the nuclear transcription factor peroxisome proliferator-activated receptor-gamma (PPAR-gamma) are used for the treatment of type 2 diabetes. We reviewed their efficacy and safety for the treatment of major depression and the association of their potential antidepressant effects with changes in biomarkers of metabolism and inflammation.
   Methods From 8 studies, 4 open-label trials, and 4 randomized controlled trials (RCT) (3 vs. placebo and 1 vs. metformin), 448 patients with major depression were included, of which 209 patients received PPAR-gamma agonists (pioglitazone or rosiglitazone) for 6-12 weeks, either alone or in add-on therapy to conventional treatments.
   Results PPAR-gamma agonists have antidepressant effects in the 4 open-label studies and in 3 out of 4 RCT. No major adverse event was reported. Improvement in depression scores was associated with improvement in 3 biomarkers of insulin resistance (homeostatic model assessment [HOMA-IR], oral glucose tolerance test, and fasting plasma glucose) and 1 biomarker of inflammation (interleukin-6) among 21 biomarkers studied.
   Conclusion PPAR-gamma agonists may have antidepressant properties, which need to be assessed in further studies of major depressive episodes.
C1 [Colle, R.; de Larminat, D.; Rotenberg, S.; Hozer, F.; Hardy, P.; Verstuyft, C.; Corruble, E.] Univ Paris Sud, Le Kremlin Bicetre, France.
   [Colle, R.; de Larminat, D.; Rotenberg, S.; Hozer, F.; Hardy, P.; Corruble, E.] INSERM, UMRS 1178, Le Kremlin Bicetre, France.
   [Colle, R.; de Larminat, D.; Rotenberg, S.; Hozer, F.; Hardy, P.; Verstuyft, C.; Corruble, E.] Hop Univ Paris Sud, Hop Bicetre, Assistance Publ Hop Paris, Le Kremlin Bicetre, France.
   [Colle, R.; de Larminat, D.; Rotenberg, S.; Hozer, F.; Hardy, P.; Corruble, E.] Dept Psychiat, Le Kremlin Bicetre, France.
   [Verstuyft, C.] INSERM, Ctr IMVA, UMR S1184, F-75654 Paris 13, France.
   [Verstuyft, C.] Serv Genet Mol Pharmacogenet & Hormonol, Paris, France.
   [Feve, B.] Sorbonne Univ, Univ Pierre & Marie Curie, INSERM, Ctr Rech St Antoine,UMR S938, Paris, France.
   [Feve, B.] Inst Hosp Univ ICAN, Paris, France.
   [Feve, B.] Hop St Antoine, Assistance Publ Hop Paris, Serv Endocrinol, Paris, France.
C3 Universite Paris Saclay; Institut National de la Sante et de la
   Recherche Medicale (Inserm); Universite Paris Cite; Universite Paris
   Saclay; Assistance Publique Hopitaux Paris (APHP); Universite Paris
   Cite; Hopital Universitaire Saint-Louis - APHP; Hopital Universitaire
   Antoine-Beclere - APHP; Hopital Universitaire Bicetre - APHP; Institut
   National de la Sante et de la Recherche Medicale (Inserm); Sorbonne
   Universite; Institut National de la Sante et de la Recherche Medicale
   (Inserm); Assistance Publique Hopitaux Paris (APHP); Sorbonne
   Universite; Hopital Universitaire Saint-Antoine - APHP; Universite Paris
   Cite; Hopital Universitaire Saint-Louis - APHP
RP Colle, R (corresponding author), CHU Bicetre, Dept Psychiat, 78 Rue Gen Leclerc, Le Kremlin Bicetre, France.
EM romaincolle@hotmail.com
RI verstuyft, celine/AAU-3343-2021; Colle, Romain/IQV-1876-2023
OI verstuyft, celine/0000-0002-8534-224X; Hozer, Franz/0000-0003-4592-0532;
   Colle, Romain/0000-0002-2549-4495; Feve, Bruno/0000-0001-6577-9009
FU Astra-Zeneca; Sanofi; NovoNordisk; MSD
FX Romain Colle, Delphine de Larminat, Samuel Rotenberg, Franz Hozer,
   Patrick Hardy, Celine Verstuyft, and Emmanuelle Corruble declare no
   potential conflict of interest. Bruno Feve has received conference fees
   for Astra-Zeneca, Sanofi, NovoNordisk, and MSD and consulting fees from
   Sanofi.
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NR 62
TC 77
Z9 81
U1 0
U2 16
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0176-3679
EI 1439-0795
J9 PHARMACOPSYCHIATRY
JI Pharmacopsychiatry
PD MAR
PY 2017
VL 50
IS 2
BP 49
EP 55
DI 10.1055/s-0042-120120
PG 7
WC Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Pharmacology & Pharmacy; Psychiatry
GA ER3JR
UT WOS:000398693600001
PM 27978584
DA 2025-06-11
ER

PT J
AU Gasparro, R
   Gambino, G
   Duca, G
   Di Majo, D
   Di Liberto, V
   Tinnirello, V
   Urone, G
   Ricciardi, N
   Frinchi, M
   Ganji, NR
   Vergilio, G
   Zummo, FP
   Rappa, F
   Fontana, S
   Conigliaro, A
   Sardo, P
   Ferraro, G
   Alessandro, R
   Raimondo, S
AF Gasparro, Roberta
   Gambino, Giuditta
   Duca, Giulia
   Di Majo, Danila
   Di Liberto, Valentina
   Tinnirello, Vincenza
   Urone, Giulia
   Ricciardi, Nicolo
   Frinchi, Monica
   Ganji, Nima Rabienezhad
   Vergilio, Giuseppe
   Zummo, Francesco Paolo
   Rappa, Francesca
   Fontana, Simona
   Conigliaro, Alice
   Sardo, Pierangelo
   Ferraro, Giuseppe
   Alessandro, Riccardo
   Raimondo, Stefania
TI Protective effects of lemon nanovesicles: evidence of the Nrf2/HO-1
   pathway contribution from in vitro hepatocytes and in vivo high-fat
   diet-fed rats
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Article
DE Lemon-derived nanovesicles; Oxidative stress; Liver; High-fat diet fed
   rats; Metabolic syndrome
ID OXIDATIVE STRESS; LIPID-PEROXIDATION; ANTIOXIDANT; PLASMA; NRF2;
   ACTIVATION
AB The cross-talk between plant-derived nanovesicles (PDNVs) and mammalian cells has been explored by several investigations, underlining the capability of these natural nanovesicles to regulate several molecular pathways. Additionally, PDNVs possess biological proprieties that make them applicable against pathological conditions, such as hepatic diseases. In this study we explored the antioxidant properties of lemon-derived nanovesicles, isolated at laboratory (LNVs) and industrial scale (iLNVs) in human healthy hepatocytes (THLE-2) and in metabolic syndrome induced by a high-fat diet (HFD) in the rat. Our findings demonstrate that in THLE-2 cells, LNVs and iLNVs decrease ROS production and upregulate the expression of antioxidant mediators, Nrf2 and HO1. Furthermore, the in vivo assessment reveals that the oral administration of iLNVs improves glucose tolerance and lipid dysmetabolism, ameliorates biometric parameters and systemic redox homeostasis, and upregulates Nrf2/HO-1 signaling in HFD rat liver. Consequently, we believe LNVs/iLNVs might be a promising approach for managing hepatic and dysmetabolic disorders.
C1 [Gasparro, Roberta; Duca, Giulia; Tinnirello, Vincenza; Ganji, Nima Rabienezhad; Fontana, Simona; Conigliaro, Alice; Alessandro, Riccardo; Raimondo, Stefania] Univ Palermo, Dept Biomed Nurosci & Adv Diagnost Bi N D, Sect Biol & Genet, I-90133 Palermo, Italy.
   [Gambino, Giuditta; Di Majo, Danila; Di Liberto, Valentina; Urone, Giulia; Ricciardi, Nicolo; Frinchi, Monica; Sardo, Pierangelo; Ferraro, Giuseppe] Univ Palermo, Dept Biomed Nurosci & Adv Diagnost Bi N D, Sect Human Physiol, I-90134 Palermo, Italy.
   [Vergilio, Giuseppe; Zummo, Francesco Paolo; Rappa, Francesca] Univ Palermo, Inst Human Anat & Histol, Dept Biomed Neurosci & Adv Diagnost BIND, I-90127 Palermo, Italy.
   [Rappa, Francesca] Natl Res Council Italy CNR, Inst Translat Pharmacol, I-90146 Palermo, Italy.
   [Conigliaro, Alice] Univ Palermo, ATeN Adv Technol Network Ctr, Viale Sci, I-90128 Palermo, Italy.
   [Conigliaro, Alice; Alessandro, Riccardo; Raimondo, Stefania] Univ Palermo, Navhetec Srl, Palermo, Italy.
   [Alessandro, Riccardo] Natl Res Council CNR, Inst Biomed Res & Innovat IRIB, I-90146 Palermo, Italy.
C3 University of Palermo; University of Palermo; University of Palermo;
   Consiglio Nazionale delle Ricerche (CNR); Istituto di Farmacologia
   Traslazionale (IFT-CNR); University of Palermo; University of Palermo;
   Consiglio Nazionale delle Ricerche (CNR); Istituto Ricerca l'Innovazione
   Biomedica (IRIB-CNR)
RP Raimondo, S (corresponding author), Univ Palermo, Dept Biomed Nurosci & Adv Diagnost Bi N D, Sect Biol & Genet, I-90133 Palermo, Italy.
EM stefania.raimondo@unipa.it
RI Di+Liberto, Valentina/ACL-0264-2022; Di Majo, Danila/A-9078-2015;
   Francesca, Rappa/ADW-8431-2022; Ganji, Nima/ADX-0319-2022; Zummo,
   Francesco Paolo/HME-2405-2023; Tinnirello, Vincenza/MBG-9139-2025;
   Conigliaro, Alice/ACW-5549-2022; Fontana, Simona/AAI-9072-2020
OI Frinchi, Monica/0000-0002-1061-5725; Rabie Nezhad Ganji,
   Nima/0000-0001-9408-3721; Tinnirello, Vincenza/0009-0001-0715-370X;
   Gambino, Giuditta/0000-0001-8155-2808
FU University of Palermo [1105/2023]
FX This work was fund by a grant from the University of Palermo (Incentivi
   ad attivita' di ricerca interdisciplinare, numero repertorio: 1105/2023;
   principal investigator Stefania Raimondo. Collaborators: Giuditta
   Gambino, Riccardo Alessandro, Giuseppe Ferraro) and in part by FFR 2023
   from the University of Palermo to Valentina Di Liberto. R. G., G.D. and
   V.T. are PhD students in "Biomedicina, Neuroscienze e Diagnostica
   Avanzata" at the University of Palermo.
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NR 70
TC 1
Z9 1
U1 7
U2 11
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD NOV
PY 2024
VL 180
AR 117532
DI 10.1016/j.biopha.2024.117532
EA OCT 2024
PG 14
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA I7O3U
UT WOS:001332111700001
PM 39383731
OA gold
DA 2025-06-11
ER

PT J
AU Zerach, G
   Shevlin, M
   Solomon, Z
AF Zerach, Gadi
   Shevlin, Mark
   Solomon, Zahava
TI Associations Between Hardiness, C-Reactive Protein, and Telomere Length
   Among Former Prisoners of War
SO HEALTH PSYCHOLOGY
LA English
DT Article
DE PTSD; hardiness; CRP; telomere length; veterans
ID POSTTRAUMATIC-STRESS-DISORDER; REPATRIATED PRISONERS; METABOLIC
   SYNDROME; II PRISONERS; HEALTH; SENESCENCE; ADJUSTMENT; MORTALITY;
   RESPONSES; CAPTIVITY
AB Background: War captivity and posttraumatic stress disorder (PTSD) are known to be associated with several poor health outcomes of an accelerated aging process. However, the contribution of personality protective factors to this phenomenon are rarely studied. The present 24-year prospective study examined associations between psychological hardiness and three health outcomes: C-reactive protein (CRP) levels, metabolic syndrome (MetS), and telomere length (TL). Method: Eighty-eight Israeli former prisoners of war (ex-POWs) were assessed 18 (T1) and 42 (T2) years after repatriation. Data on hardiness was collected at T1 while leukocyte TL, CRP, and MetS data was collected 42 years after the war. Results: While adjusting for age, body mass index (BMI), self-rated health, depressive and PTSD symptoms at T2, higher levels of hardiness at T1 predicted decreased CRP and longer TL at T2. Conclusions: Long-term health vulnerabilities of traumatized ex-POWs are manifested in an accelerated aging process and cellular senescence. Raising awareness of the importance of protective factors such as veterans' hardiness might be associated with improving their longevity and well-being.
C1 [Zerach, Gadi] Ariel Univ, Dept Behav Sci & Psychol, IL-40700 Ariel, Israel.
   [Shevlin, Mark] Ulster Univ, Sch Psychol, Coleraine, Londonderry, North Ireland.
   [Solomon, Zahava] Tel Aviv Univ, Ctr Excellence Mass Trauma Res, Tel Aviv, Israel.
C3 Ariel University; Ulster University; Tel Aviv University
RP Zerach, G (corresponding author), Ariel Univ, Dept Behav Sci & Psychol, IL-40700 Ariel, Israel.
EM gadize@ariel.ac.il
RI Zerach, Gadi/GLU-1118-2022; Shevlin, Mark/I-3242-2017
OI Shevlin, Mark/0000-0001-6262-5223
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NR 45
TC 4
Z9 6
U1 0
U2 9
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 0278-6133
EI 1930-7810
J9 HEALTH PSYCHOL
JI Health Psychol.
PD NOV
PY 2020
VL 39
IS 11
BP 1007
EP 1012
DI 10.1037/hea0001030
PG 6
WC Psychology, Clinical; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology
GA OH2EX
UT WOS:000582383700007
PM 32969697
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Paltoglou, G
   Raftopoulou, C
   Nicolaides, NC
   Genitsaridi, SM
   Karampatsou, SI
   Papadopoulou, M
   Kassari, P
   Charmandari, E
AF Paltoglou, George
   Raftopoulou, Christina
   Nicolaides, Nicolas C.
   Genitsaridi, Sofia M.
   Karampatsou, Sofia I.
   Papadopoulou, Marina
   Kassari, Penio
   Charmandari, Evangelia
TI A Comprehensive, Multidisciplinary, Personalized, Lifestyle Intervention
   Program Is Associated with Increased Leukocyte Telomere Length in
   Children and Adolescents with Overweight and Obesity
SO NUTRIENTS
LA English
DT Article
DE overweight; obesity; leukocyte telomere length; childhood; adolescence
ID TO-HEIGHT RATIO; INSULIN-RESISTANCE; CARDIOMETABOLIC RISK; OXIDATIVE
   STRESS; PULSE PRESSURE; INFLAMMATION; INDEX; MORTALITY; PRESCHOOL;
   ACCURACY
AB Leucocyte telomere length (LTL) is a robust marker of biological aging and is associated with obesity and cardiometabolic risk factors in childhood and adolescence. We investigated the effect of a structured, comprehensive, multidisciplinary, personalized, lifestyle intervention program of healthy diet and physical exercise on LTL in 508 children and adolescents (239 males, 269 females; 282 prepubertal, 226 pubertal), aged 10.14 +/- 0.13 years. Participants were classified as obese (n = 267, 52.6%), overweight (n = 174, 34.2%), or of normal BMI (n = 67, 13.2%) according to the International Obesity Task Force (IOTF) cutoff points and were studied prospectively for one year. We demonstrated that LTL increased significantly after 1 year of the lifestyle interventions, irrespective of gender, pubertal status, or body mass index (BMI). Waist circumference was the best negative predictor of LTL at initial assessment. The implementation of the lifestyle interventions also resulted in a significant improvement in clinical (BMI, BMI z-score and waist to height ratio) and body composition indices of obesity, inflammatory markers, hepatic enzymes, glycated hemoglobin (HbA1C), quantitative insulin sensitivity check index (QUICKI), and lipid profile in all participants. These findings indicate that the increased LTL may be associated with a more favorable metabolic profile and decreased morbidity later in life.
C1 [Paltoglou, George; Nicolaides, Nicolas C.; Genitsaridi, Sofia M.; Karampatsou, Sofia I.; Papadopoulou, Marina; Kassari, Penio; Charmandari, Evangelia] Natl & Kapodistrian Univ, Aghia Sophia Childrens Hosp, Athens Med Sch, Dept Pediat 1,Div Endocrinol Metab & Diabet, Athens 11527, Greece.
   [Raftopoulou, Christina; Charmandari, Evangelia] Acad Athens, Biomed Res Fdn, Ctr Clin Expt Surg & Translat Res, Div Endocrinol & Metab, Athens 11527, Greece.
C3 National & Kapodistrian University of Athens; The Aghia Sophia
   Children's Hospital; Academy of Athens
RP Charmandari, E (corresponding author), Natl & Kapodistrian Univ, Aghia Sophia Childrens Hosp, Athens Med Sch, Dept Pediat 1,Div Endocrinol Metab & Diabet, Athens 11527, Greece.; Charmandari, E (corresponding author), Acad Athens, Biomed Res Fdn, Ctr Clin Expt Surg & Translat Res, Div Endocrinol & Metab, Athens 11527, Greece.
EM gpaltoglou@gmail.com; xraftopoulou@yahoo.gr; nicolaidesnc@gmail.com;
   sgenitsaridi@gmail.com; karampatsousi@gmail.com;
   marinageorpap@gmail.com; peniokassari@gmail.com;
   evangelia.charmandari@googlemail.com
RI Charmandari, Evangelia/AAF-2038-2019; Paltoglou, George/B-6944-2019
OI Charmandari, Evangelia/0000-0002-0851-6998; Paltoglou,
   George/0000-0003-4300-7061; Raftopoulou, Christina/0000-0002-5132-2822;
   Kassari, Penio/0000-0003-2464-1825
FU European Regional Development Fund of the European Union; Greek national
   funds through the Operational Program Competitiveness, Entrepreneurship
   and Innovation [T1EDK-01386, MIS: 5030543]
FX This research was cofinanced by the European Regional Development Fund
   of the European Union and Greek national funds through the Operational
   Program Competitiveness, Entrepreneurship and Innovation, under the call
   RESEARCH-CREATE-INNOVATE (project code: T1EDK-01386, MIS: 5030543,
   Acronym: PEDOBESITY).
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NR 56
TC 13
Z9 14
U1 0
U2 3
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD AUG
PY 2021
VL 13
IS 8
AR 2682
DI 10.3390/nu13082682
PG 18
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA UH5QY
UT WOS:000689986400001
PM 34444842
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Sallam, HS
   Tuvdendorj, DR
   Jialal, I
   Chandalia, M
   Abate, N
AF Sallam, Hanaa S.
   Tuvdendorj, Demidmaa R.
   Jialal, Ishwarlal
   Chandalia, Manisha
   Abate, Nicola
TI Therapeutic lifestyle change intervention improved metabolic syndrome
   criteria and is complementary to amlodipine/atorvastatin
SO JOURNAL OF DIABETES AND ITS COMPLICATIONS
LA English
DT Article
DE Amlodipine/atorvastatin; Therapeutic lifestyle; Ox-LDL; Oxidative
   stress; Metabolic syndrome
ID OXIDATIVE STRESS; ADIPOSE-TISSUE; BLOOD-PRESSURE; INSULIN SENSITIVITY;
   CARDIOVASCULAR RISK; WEIGHT-LOSS; OBESE; EXERCISE; ADULTS; CHOLESTEROL
AB Aims: To examine whether addition of amlodipine (5 mg)/atorvastatin (10 mg) A/A to Therapeutic Lifestyle change intervention (TLC) would beneficially modulate Metabolic Syndrome (MetS) and oxidized low-density lipoprotein (Ox-LDL) levels.
   Methods: Patients with MetS (n = 53) were randomized to TLC + placebo or TLC + A/A for 12 months. Anthropometric measurements, blood pressure (BP), lipid profile, plasma Ox-LDL, and area under the curve of free fatty acid (AUC(FFA)) during oral glucose tolerance test, a marker of adipose tissue health, were assessed before and after the intervention.
   Results: Twenty-six patients completed the study with an overall improvement of MetS (p = 0.02). TLC + placebo was beneficial in reversing MetS comparable to TLC + A/A (54% vs. 39%; p = 0.08). Both treatments decreased systolic BP (p <= 0.01). TLC + A/A also decreased diastolic BP and triglyceride levels. The changes in Ox-LDL levels directly correlated with changes in weight in the TLC-placebo group (r = 0.64; p = 0.04). AUC(FFA) determined the loss of fat mass (r = 0.472, p = 0.03).
   Conclusions: 1) Addition of A/A has the advantage of improving the lipid profile and BP; but TLC alone was comparable to TLC + A/A in improving MetS: 2) weight change determines the TLC-associated change in Ox-LDL levels; and 3) AT metabolic health is a significant predictor of TLC-associated loss of body fat mass. (C) 2019 Elsevier Inc. All rights reserved.
C1 [Sallam, Hanaa S.; Tuvdendorj, Demidmaa R.; Abate, Nicola] Univ Texas Med Branch, Dept Internal Med, Galveston, TX 77555 USA.
   [Chandalia, Manisha; Abate, Nicola] Bay Area Metab Hlth, Baytown, TX USA.
   [Jialal, Ishwarlal] Calif North State Univ, Coll Med, Elk Grove, CA USA.
   [Sallam, Hanaa S.] Suez Canal Univ, Fac Med, Dept Physiol, Ismailia, Egypt.
C3 University of Texas System; University of Texas Medical Branch
   Galveston; Egyptian Knowledge Bank (EKB); Suez Canal University
RP Abate, N (corresponding author), Univ Texas Med Branch, Dept Internal Med, Div Endocrinol, Galveston, TX 77555 USA.
EM nicola.abate13@gmail.com
RI Sallam, Hanaa/ABD-7361-2020; Tuvdendorj, Demidmaa/AAC-4196-2019
FU Pfizer Inc.; Clinical and Translational Science Award from the National
   Center for Advancing Translational Sciences, National Institutes of
   Health [UL1 TR001439]; Mentored Career Development (KL2) Award from the
   National Center for Advancing Translational Sciences, National
   Institutes of Health [KL2TR001441]; Institute for Translational Sciences
   at the University of Texas Medical Branch
FX This study was funded by Pfizer Inc., and conducted with the support of
   the Institute for Translational Sciences at the University ofTexas
   Medical Branch, supported in part by a Clinical and Translational
   Science Award (UL1 TR001439) and Mentored Career Development (KL2) Award
   (KL2TR001441) from the National Center for Advancing Translational
   Sciences, National Institutes of Health. The content is solely the
   responsibility of the authors and does not necessarily represent the
   official views of the National Institutes of Health.
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NR 37
TC 2
Z9 2
U1 1
U2 4
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1056-8727
EI 1873-460X
J9 J DIABETES COMPLICAT
JI J. Diabetes Complications
PD MAR
PY 2020
VL 34
IS 3
AR 107480
DI 10.1016/j.jdiacomp.2019.107480
PG 5
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA KO3KH
UT WOS:000515446800011
PM 31902653
DA 2025-06-11
ER

PT J
AU Kaya, A
   Koçyigit, C
   Çatli, G
   Özkan, EB
   Dündar, BN
AF Kaya, Abdurrahman
   Kocyigit, Cemil
   Catli, Gonul
   Ozkan, Elif Busra
   Dundar, Bumin Nuri
TI The Relationship Between Glycemic Variability and Inflammatory Markers
   in Obese Children with Insulin Resistance and Metabolic Syndrome
SO JOURNAL OF CLINICAL RESEARCH IN PEDIATRIC ENDOCRINOLOGY
LA English
DT Article
DE Glycemic variability; metabolic syndrome; interleukin-6; adiponectin
ID ENDOTHELIAL FUNCTION; OXIDATIVE STRESS; TURKISH CHILDREN; ADOLESCENTS;
   ADIPONECTIN; GLUCOSE
AB Objective: Increased glycemic variability (GV) is associated with increased oxidative stress, vascular complications, and mortality in metabolic syndrome (MS) and diabetes mellitus patients. To investigate the relationship between GV and inflammatory parameters in obese children with insulin resistance (IR) and to elucidate their effects on the development of MS.
   Methods: Fifty obese adolescents with IR were included in the study. All patients underwent anthropometric measurements, body fat analysis, and continuous glucose monitoring system (CGMS) for 24 hours. Serum lipids, adiponectin, and interleukin-6 (IL-6) levels were measured. GV coefficient (GVC) was calculated using the standard deviation and the average glucose value obtained by CGMS. IR was diagnosed according to the results of oral glucose tolerance test (OGTT). MS was diagnosed according to the modified World Health Organization and the International Diabetes Federation criteria.
   Results: Twenty-seven of the patients had MS and the remaining had only IR. Body fat mass, HbA1c, IL-6 levels, and peak insulin levels in the OGTT were significantly higher in the group with MS, but there was no difference in adiponectin levels. GVC was not different between the groups, but GVC significantly positively correlated with homeostasis model of assessment for IR, as well as with fasting, peak, and total insulin levels when all the patients were analyzed, while no significant relation was detected with adiponectin and IL-6 levels.
   Conclusion: This study suggests that GV is not different among obese adolescents with IR and MS. There seems to be a significant association between GV and IR parameters. However, other diagnostic criteria of MS (hypertension and/or dyslipidemia) or elevated IL-6 levels does not cause further increase in GV.
C1 [Kaya, Abdurrahman] Tepec Training & Res Hosp, Clin Pediat, Izmir, Turkey.
   [Kocyigit, Cemil; Catli, Gonul; Dundar, Bumin Nuri] Izmir Katip Celebi Univ, Fac Med, Dept Pediat Endocrinol, Izmir, Turkey.
   [Ozkan, Elif Busra] Izmir Katip Celebi Univ, Fac Med, Izmir, Turkey.
C3 Izmir Tepecik Training & Research Hospital; Izmir Katip Celebi
   University; Izmir Katip Celebi University
RP Dündar, BN (corresponding author), Izmir Katip Celebi Univ, Fac Med, Dept Pediat Endocrinol, Izmir, Turkey.
EM bumindundar@gmail.com
RI koçyiğit, cemil/JYP-4433-2024; Catli, Gönül/AFT-1499-2022; Dündar,
   Bumin/JVE-1747-2024
OI Dundar, Bumin N/0000-0002-7506-061X; Catli, Gonul/0000-0002-0488-6377
CR Balkau B, 1999, DIABETIC MED, V16, P442
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NR 16
TC 19
Z9 19
U1 0
U2 5
PU GALENOS YAYINCILIK
PI FINDIKZADE
PA ERKAN MOR, MOLLA GURANI CAD 21-1, FINDIKZADE, ISTANBUL 34093, TURKEY
SN 1308-5727
EI 1308-5735
J9 J CLIN RES PEDIATR E
JI J. Clin Res. Pediatr. Endocrinol.
PD SEP
PY 2017
VL 9
IS 3
BP 202
EP 207
DI 10.4274/jcrpe.4031
PG 6
WC Endocrinology & Metabolism; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Pediatrics
GA FG5TV
UT WOS:000410406300003
PM 28163257
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Yu, H
   Yi, XZ
   Gao, X
   Ji, J
   Liu, ZY
   Xia, GH
   Li, CA
   Zhang, XY
   Shen, XR
AF Yu, Hui
   Yi, Xiangzhou
   Gao, Xia
   Ji, Jun
   Liu, Zhongyuan
   Xia, Guanghua
   Li, Chuan
   Zhang, Xueying
   Shen, Xuanri
TI Tilapia-Head Chondroitin Sulfate Protects against Nonalcoholic Fatty
   Liver Disease via Modulating the Gut-Liver Axis in High-Fat-Diet-Fed
   C57BL/6 Mice
SO FOODS
LA English
DT Article
DE tilapia head; chondroitin sulfate; nonalcoholic fatty liver disease;
   gut-liver axis
ID METABOLIC SYNDROME; OXIDATIVE STRESS; MICROBIOTA; POLYSACCHARIDES;
   OLIGOSACCHARIDES; PRODUCTS; EXTRACT
AB We isolated and characterized tilapia-head chondroitin sulfate (TH-CS) and explored its biological activity and mechanisms of action as an oral supplement for nonalcoholic fatty liver disease (NAFLD) induced by a high-fat diet (HFD) in mice. The results showed that treatment with TH-CS for 8 weeks alleviated the development of NAFLD, as evidenced by the notable improvement in liver damage, blood lipid accumulation and insulin resistance (IR). Meanwhile, TH-CS treatment reduced the expression of proinflammatory cytokines and normalized oxidative stress. Additionally, the analysis of 16S rDNA sequencing revealed that TH-CS could restore gut microbiota balance and increase the relative abundance of short-chain fatty acid (SCFA)-producing bacteria. Furthermore, SCFAs produced by related bacteria can further improve lipid metabolism and IR by regulating lipid synthesis signals. In conclusion, TH-CS is an effective dietary supplement for the prevention of NAFLD, and may serve as a potential supplementary treatment for lipid-related metabolic syndrome.
C1 [Yu, Hui; Yi, Xiangzhou; Gao, Xia; Ji, Jun; Liu, Zhongyuan; Xia, Guanghua; Li, Chuan; Zhang, Xueying; Shen, Xuanri] Hainan Univ, Hainan Engn Res Ctr Aquat Resources Efficient Uti, Haikou 570228, Hainan, Peoples R China.
   [Yu, Hui; Yi, Xiangzhou; Gao, Xia; Ji, Jun; Liu, Zhongyuan; Xia, Guanghua; Li, Chuan; Zhang, Xueying; Shen, Xuanri] Hainan Univ, Coll Food Sci & Technol, Haikou 570228, Hainan, Peoples R China.
   [Liu, Zhongyuan; Xia, Guanghua; Li, Chuan; Zhang, Xueying; Shen, Xuanri] Dalian Polytech Univ, Collaborat Innovat Ctr Marine Food Deep Proc, Dalian 116000, Peoples R China.
C3 Hainan University; Hainan University; Dalian Polytechnic University
RP Shen, XR (corresponding author), Hainan Univ, Hainan Engn Res Ctr Aquat Resources Efficient Uti, Haikou 570228, Hainan, Peoples R China.; Shen, XR (corresponding author), Hainan Univ, Coll Food Sci & Technol, Haikou 570228, Hainan, Peoples R China.; Shen, XR (corresponding author), Dalian Polytech Univ, Collaborat Innovat Ctr Marine Food Deep Proc, Dalian 116000, Peoples R China.
EM yuhui19970607@163.com; xiangzhouyi1995@hainanu.edu.cn;
   gaoxia20202021@163.com; jijunbest@126.com; liuzhongyuan999@126.com;
   xiaguanghua@vip.163.com; lichuanbest@126.com; 994257@hainanu.edu.cn;
   xuanrishen@hainanu.edu.cn
RI Xia, Guanghua/AAN-1812-2021; Yi, Xiangzhou/GZG-3068-2022; zhang,
   xueying/JMB-7808-2023
FU National Key R&D Programs of China [2018YFD0901103]; Project of Haikou
   Ocean and Fisheries Bureau [HHCL201804]
FX This research was funded by the National Key R&D Programs of China,
   grant number 2018YFD0901103 and the Project of Haikou Ocean and
   Fisheries Bureau, grant number HHCL201804.
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NR 42
TC 8
Z9 8
U1 4
U2 56
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2304-8158
J9 FOODS
JI Foods
PD APR
PY 2022
VL 11
IS 7
AR 922
DI 10.3390/foods11070922
PG 19
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA 0L2SN
UT WOS:000781329800001
PM 35407014
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Gaspar, RS
   Trostchansky, A
   Paes, AMD
AF Gaspar, Renato Simoes
   Trostchansky, Andres
   de Andrade Paes, Antonio Marcus
TI Potential Role of Protein Disulfide Isomerase in Metabolic
   Syndrome-Derived Platelet Hyperactivity
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Review
ID VASCULAR SMOOTH-MUSCLE; TRANSIENT ISCHEMIC ATTACK; NADPH-OXIDASE 1;
   NITRIC-OXIDE; OXIDATIVE STRESS; CARDIOVASCULAR RISK; THROMBUS FORMATION;
   INSULIN-RECEPTOR; NAD(P)H OXIDASE; ACTIVATION
AB Metabolic Syndrome (MetS) has become a worldwide epidemic, alongside with a high socioeconomic cost, and its diagnostic criteria must include at least three out of the five features: visceral obesity, hypertension, dyslipidemia, insulin resistance, and high fasting glucose levels. MetS shows an increased oxidative stress associated with platelet hyperactivation, an essential component for thrombus formation and ischemic events in MetS patients. Platelet aggregation is governed by the peroxide tone and the activity of Protein Disulfide Isomerase (PDI) at the cell membrane. PDI redox active sites present active cysteine residues that can be susceptible to changes in plasma oxidative state, as observed in MetS. However, there is a lack of knowledge about the relationship between PDI and platelet hyperactivation under MetS and its metabolic features, in spite of PDI being a mediator of important pathways implicated in MetS-induced platelet hyperactivation, such as insulin resistance and nitric oxide dysfunction. Thus, the aim of this review is to analyze data available in the literature as an attempt to support a possible role for PDI in MetS-induced platelet hyperactivation.
C1 [Gaspar, Renato Simoes; de Andrade Paes, Antonio Marcus] Univ Fed Maranhao, Dept Physiol Sci, Lab Expt Physiol, Sao Luis, MA, Brazil.
   [Trostchansky, Andres] Univ Republica, Dept Bioquim, Montevideo, Uruguay.
   [Trostchansky, Andres] Univ Republica, Fac Med, Ctr Free Rad & Biomed Res, Montevideo, Uruguay.
   [Trostchansky, Andres; de Andrade Paes, Antonio Marcus] Univ Fed Maranhao, Hlth Sci Grad Program, Biol & Hlth Sci Ctr, Sao Luis, MA, Brazil.
C3 Universidade Federal do Maranhao; Universidad de la Republica, Uruguay;
   Universidad de la Republica, Uruguay; Universidade Federal do Maranhao
RP Paes, AMD (corresponding author), Univ Fed Maranhao, Dept Physiol Sci, Lab Expt Physiol, Sao Luis, MA, Brazil.; Paes, AMD (corresponding author), Univ Fed Maranhao, Hlth Sci Grad Program, Biol & Hlth Sci Ctr, Sao Luis, MA, Brazil.
EM marcuspaes@ufma.br
RI Gaspar, Renato/N-7061-2019; Trostchansky, Andres/I-5624-2019; Paes,
   Antonio Marcus de Andrade/C-7174-2013
OI Simoes Gaspar, Renato/0000-0001-6639-9470; Trostchansky,
   Andres/0000-0002-9721-7577; Paes, Antonio Marcus de
   Andrade/0000-0002-3803-9803
FU Fundacao de Amparo a Pesquisa e ao Desenvolvimento Cientifico e
   Tecnologico do Maranhao, FAPEMA [APP 0395/12, ESTAGIO 0814/13, APCINTER
   02698/14]; Conselho Nacional de Desenvolvimento Cientifico e
   Tecnologico, CNPq [485251/2012-4]; CSIC grupos I+D [536]; FAPEMA
   [PVI-05558/15]
FX The authors thank the Fundacao de Amparo a Pesquisa e ao Desenvolvimento
   Cientifico e Tecnologico do Maranhao, FAPEMA (APP 0395/12, ESTAGIO
   0814/13, APCINTER 02698/14) and Conselho Nacional de Desenvolvimento
   Cientifico e Tecnologico, CNPq (485251/2012-4). Andres Trostchansky was
   supported by CSIC grupos I+D 2014 (536) and FAPEMA (PVI-05558/15).
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NR 103
TC 12
Z9 13
U1 0
U2 4
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PY 2016
VL 2016
AR 2423547
DI 10.1155/2016/2423547
PG 10
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA EF8FF
UT WOS:000390563700001
PM 28053690
OA Green Submitted, Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Piva, SJ
   Duarte, MMMF
   Da Cruz, IBM
   Coelho, AC
   Moreira, APL
   Tonello, R
   Garcia, SC
   Moresco, RN
AF Piva, Silvia J.
   Duarte, Marta M. M. F.
   Da Cruz, Ivana B. M.
   Coelho, Adriane C.
   Moreira, Ana Paula L.
   Tonello, Raquel
   Garcia, Solange C.
   Moresco, Rafael N.
TI Ischemia-modified albumin as an oxidative stress biomarker in obesity
SO CLINICAL BIOCHEMISTRY
LA English
DT Article
DE Human serum albumin; Obesity; Oxidative stress
ID METABOLIC SYNDROME; ASSOCIATION; INFLAMMATION; PLASMA; LIPIDS
AB Objective: We evaluated the levels of ischemia-modified albumin (IMA) and its association with body mass index (BMI) in patients who are obese.
   Design and methods: Fasting glucose, total cholesterol, HDL cholesterol, LDL cholesterol, triglycerides, malondialdehyde, and IMA levels were assessed in 148 subjects.
   Results: IMA, malondialdehyde, and fasting glucose levels were significantly higher while the HDL cholesterol levels were lower in obese population.
   Conclusions: IMA levels increase in overweight and obese subjects. (C) 2010 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
C1 [Piva, Silvia J.; Moresco, Rafael N.] Univ Fed Santa Maria, Ctr Ciencias Saude, Dept Anal Clin & Toxicol, Lab Bioquim Clin, BR-97105900 Santa Maria, RS, Brazil.
   [Piva, Silvia J.; Moreira, Ana Paula L.; Moresco, Rafael N.] Univ Fed Santa Maria, Ctr Ciencias Saude, Programa Posgrad Cieencias Farmaceut, BR-97105900 Santa Maria, RS, Brazil.
   [Duarte, Marta M. M. F.] Univ Luterana Brasil, Dept Ciencias Saude, Santa Maria, RS, Brazil.
   [Da Cruz, Ivana B. M.; Garcia, Solange C.; Moresco, Rafael N.] Univ Fed Santa Maria, Ctr Ciencias Saude, Programa Posgrad & Farmacol, BR-97105900 Santa Maria, RS, Brazil.
   [Da Cruz, Ivana B. M.; Tonello, Raquel] Univ Fed Santa Maria, Ctr Ciencias Saude, Programa Posgrad Bioquim Toxciol, BR-97105900 Santa Maria, RS, Brazil.
   [Coelho, Adriane C.] Hosp Univ Santa Maria, Santa Maria, RS, Brazil.
   [Garcia, Solange C.] Univ Fed Rio Grande do Sul, Dept Anal, Lab Toxicol, Porto Alegre, RS, Brazil.
C3 Universidade Federal de Santa Maria (UFSM); Universidade Federal de
   Santa Maria (UFSM); Universidade Luterana do Brasil; Universidade
   Federal de Santa Maria (UFSM); Universidade Federal de Santa Maria
   (UFSM); Universidade Federal do Rio Grande do Sul
RP Moresco, RN (corresponding author), Univ Fed Santa Maria, Ctr Ciencias Saude, Dept Anal Clin & Toxicol, Lab Bioquim Clin, Ave Roraima 1000,Predio 26,Sala 1216, BR-97105900 Santa Maria, RS, Brazil.
EM rnmoresco@yahoo.com.br
RI Garcia, Solange/J-3039-2013; da Cruz; Manica da Cruz, Ivana/G-4329-2012;
   Moresco, Rafael/K-6118-2017
OI Garcia, Solange/0000-0003-3752-5751; da Cruz; Manica da Cruz,
   Ivana/0000-0003-3008-6899; Tonello, Raquel/0000-0002-2175-9804; Moresco,
   Rafael/0000-0003-3072-5080
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NR 11
TC 62
Z9 67
U1 2
U2 8
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0009-9120
EI 1873-2933
J9 CLIN BIOCHEM
JI Clin. Biochem.
PD MAR
PY 2011
VL 44
IS 4
BP 345
EP 347
DI 10.1016/j.clinbiochem.2010.12.001
PG 3
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA 724FN
UT WOS:000287561600015
PM 21159315
DA 2025-06-11
ER

PT J
AU Freitas, C
   Deschênes, S
   Au, BN
   Smith, K
   Schmitz, N
AF Freitas, Cassandra
   Deschenes, Sonya
   Au, Bonnie
   Smith, Kimberley
   Schmitz, Norbert
TI Risk of Diabetes in Older Adults with Co-Occurring Depressive Symptoms
   and Cardiometabolic Abnormalities: Prospective Analysis from the English
   Longitudinal Study of Ageing
SO PLOS ONE
LA English
DT Article
ID METABOLIC SYNDROME; CARDIOVASCULAR-DISEASE; TYPE-2; METAANALYSIS;
   ASSOCIATION; PREVALENCE; OBESITY; HYPERTENSION; INFLAMMATION; AGREEMENT
AB High depressive symptoms and cardiometabolic abnormalities are independently associated with an increased risk of diabetes. The purpose of this study was to assess the association of co-occurring depressive symptoms and cardiometabolic abnormalities on risk of diabetes in a representative sample of the English population aged 50 years and older. Data were from the English Longitudinal Study of Ageing. The sample comprised of 4454 participants without diabetes at baseline. High depressive symptoms were based on a score of 4 or more on the 8-item binary Centre for Epidemiologic Studies-Depression scale. Cardiometabolic abnormalities were defined as 3 or more cardiometabolic risk factors (hypertension, impaired glycemic control, systemic inflammation, low high-density lipoprotein cholesterol, high triglycerides, and central obesity). Cox proportional hazards regressions assessed the association between co-occurring depressive symptoms and cardiometabolic abnormalities with incidence of diabetes. Multiple imputation by chained equations was performed to account for missing data. Covariates included age, sex, education, income, smoking status, physical activity, alcohol consumption, and cardiovascular comorbidity. The follow-up period consisted of 106 months, during which 193 participants reported a diagnosis of diabetes. Diabetes incidence rates were compared across the following four groups: 1) no or low depressive symptoms and no cardiometabolic abnormalities (reference group, n = 2717); 2) high depressive symptoms only (n = 338); 3) cardiometabolic abnormalities only (n = 1180); and 4) high depressive symptoms and cardiometabolic abnormalities (n = 219). Compared to the reference group, the hazard ratio for diabetes was 1.29 (95% CI 0.63, 2.64) for those with high depressive symptoms only, 3.88 (95% CI 2.77, 5.44) for those with cardiometabolic abnormalities only, and 5.56 (95% CI 3.45, 8.94) for those with both high depressive symptoms and cardiometabolic abnormalities, after adjusting for socio-demographic, lifestyle and clinical variables. These findings suggest that those with high depressive symptoms and cardiometabolic abnormalities are at a particularly increased risk of type 2 diabetes.
C1 [Freitas, Cassandra; Schmitz, Norbert] McGill Univ, Dept Epidemiol Biostat & Occupat Hlth, Montreal, PQ, Canada.
   [Freitas, Cassandra; Deschenes, Sonya; Schmitz, Norbert] Douglas Mental Hlth Univ Inst, Montreal, PQ, Canada.
   [Deschenes, Sonya; Schmitz, Norbert] McGill Univ, Dept Psychiat, Montreal, PQ, Canada.
   [Au, Bonnie] Sunnybrook Hlth Sci Ctr, Primary Care Res Unit, Toronto, ON M4N 3M5, Canada.
   [Smith, Kimberley] Brunel Univ London, Dept Life Sci, Uxbridge, Middx, England.
C3 McGill University; McGill University; University of Toronto; Sunnybrook
   Research Institute; Sunnybrook Health Science Center; Brunel University
RP Freitas, C (corresponding author), McGill Univ, Dept Epidemiol Biostat & Occupat Hlth, Montreal, PQ, Canada.; Freitas, C (corresponding author), Douglas Mental Hlth Univ Inst, Montreal, PQ, Canada.
EM cassandra.freitas@mail.mcgill.ca
RI Deschenes, Sonya/G-6341-2017; Schmitz, Norbert/AAH-3624-2020; Schmitz,
   Norbert/A-5177-2010
OI Smith, Kimberley/0000-0002-1323-627X; Schmitz,
   Norbert/0000-0001-7777-6323
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NR 53
TC 13
Z9 17
U1 0
U2 11
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAY 26
PY 2016
VL 11
IS 5
AR e0155741
DI 10.1371/journal.pone.0155741
PG 16
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Science & Technology - Other Topics
GA DN2GQ
UT WOS:000376882500030
PM 27227974
OA gold, Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Gapelyuk, A
   Wessel, N
   Fischer, R
   Zacharzowsky, U
   Koch, L
   Selbig, D
   Schütt, H
   Sawitzki, B
   Lutt, FC
   Dietz, R
   Schirdewan, A
AF Gapelyuk, Andrej
   Wessel, Niels
   Fischer, Robert
   Zacharzowsky, Udo
   Koch, Lydia
   Selbig, Daniela
   Schuett, Henry
   Sawitzki, Bianca
   Lutt, Friedrich C.
   Dietz, Rainer
   Schirdewan, Alexander
TI Detection of patients with coronary artery disease using cardiac
   magnetic field mapping at rest
SO JOURNAL OF ELECTROCARDIOLOGY
LA English
DT Article
DE cardiac magnetic field mapping; coronary artery
ID ISCHEMIC-HEART-DISEASE; MYOCARDIAL ABNORMALITY; ST DEPRESSION;
   SYNDROME-X; MAGNETOCARDIOGRAPHY; ELECTROCARDIOGRAPHY; ENDOTHELIUM;
   MECHANISM; DIAGNOSIS; SIGNAL
AB We studied the use of cardiac magnetic field mapping to detect patients with CAD without subjecting them to stress. Fifty-nine healthy control subjects and 10 1 patients with CAD without previous MI were included. The optimal positions for detecting CAD were located in the left superior parasternal and in the inferior midsternal area. Values for ST slope, ST shift, T peak amplitude, ST-T integral, and magnetic field map orientation differed significantly between the 2 groups. Three parameters together in a inultivariate analysis yielded a sensitivity of 84% and a specificity of 83% in distinguishing patients with CAD from control subjects. We suggest that cardiac magnetic field mapping is a promising technique to identify patients with CAD. (c) 2007 Elsevier Inc. All rights reserved.
C1 HELIOS Klin, Franz Volhard Klin, Fac Med Charite, Berlin, Germany.
   Univ Potsdam, Dept Phys, Potsdam, Germany.
   Max Delbruck Ctr Mol Med, Berlin, Germany.
C3 Helios Kliniken; Berlin Institute of Health; Free University of Berlin;
   Humboldt University of Berlin; Charite Universitatsmedizin Berlin;
   Franz-Volhard Clinical Research Center; University of Potsdam; Helmholtz
   Association; Max Delbruck Center for Molecular Medicine
RP Schirdewan, A (corresponding author), HELIOS Klin, Franz Volhard Klin, Fac Med Charite, Berlin, Germany.
EM alexander.schirdewan@charite.de
OI Wessel, Niels/0000-0003-0922-9971; Luft, Friedrich/0000-0002-8635-1199
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NR 36
TC 18
Z9 18
U1 1
U2 7
PU CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS
PI PHILADELPHIA
PA CURTIS CENTER, INDEPENDENCE SQUARE WEST, PHILADELPHIA, PA 19106-3399 USA
SN 0022-0736
J9 J ELECTROCARDIOL
JI J. Electrocardiol.
PD SEP-OCT
PY 2007
VL 40
IS 5
BP 401
EP 407
DI 10.1016/j.jelectrocard.2007.03.013
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 211EU
UT WOS:000249507900008
PM 17531250
DA 2025-06-11
ER

PT J
AU Araújo, JR
   Martel, F
   Keating, E
AF Araujo, Joao Ricardo
   Martel, Fatima
   Keating, Elisa
TI Exposure to non-nutritive sweeteners during pregnancy and lactation:
   Impact in programming of metabolic diseases in the progeny later in life
SO REPRODUCTIVE TOXICOLOGY
LA English
DT Review
DE Non-nutritive sweeteners; Pregnancy; Fetal programming; Metabolic
   syndrome
ID HIGH-INTENSITY SWEETENERS; ARTIFICIAL SWEETENERS; ACESULFAME-K;
   BODY-WEIGHT; FOOD-INTAKE; PRETERM DELIVERY; OXIDATIVE STRESS; GUT
   MICROBIOTA; ASPARTAME; RAT
AB The nutritional environment during embryonic, fetal and neonatal development plays a crucial role in the offspring's risk of developing diseases later in life. Although non-nutritive sweeteners (NNS) provide sweet taste without contributing to energy intake, animal studies showed that long-term consumption of NSS, particularly aspartame, starting during the perigestational period may predispose the offspring to develop obesity and metabolic syndrome later in life. In this paper, we review the impact of NNS exposure during the perigestational period on the long-term disease risk of the offspring, with a particular focus on metabolic diseases. Some mechanisms underlying NNS adverse metabolic effects have been proposed, such as an increase in intestinal glucose absorption, alterations in intestinal microbiota, induction of oxidative stress and a dysregulation of appetite and reward responses. The data reviewed herein suggest that NNS consumption by pregnant and lactating women should be looked with particular caution and requires further research. (C) 2014 Elsevier Inc. All rights reserved.
C1 [Araujo, Joao Ricardo; Martel, Fatima; Keating, Elisa] Univ Porto, Dept Biochem FCT U38, Fac Med, P-4200319 Porto, Portugal.
   [Keating, Elisa] Portuguese Catholic Univ, Sch Biotechnol, Ctr Biotechnol & Fine Chem, P-4200702 Porto, Portugal.
C3 Universidade do Porto; Universidade Catolica Portuguesa
RP Araújo, JR (corresponding author), Univ Porto, Dept Biochem FCT U38, Fac Med, P-4200319 Porto, Portugal.
EM jaraujo@med.up.pt
RI Martel, Felix/JFJ-0587-2023; Araújo, João/GRY-7522-2022; Keating,
   Elisa/JDW-8704-2023
OI Keating, Elisa/0000-0002-3904-9907; Martel, Fatima/0000-0002-0525-3416;
   Araujo, Joao Ricardo/0000-0003-2491-1047
FU Fundacao para a Ciencia e a Tecnologia (FCT); COMPETE; QREN; FEDER
   [SFRH/BD/63086/2009]; Fundação para a Ciência e a Tecnologia
   [SFRH/BD/63086/2009] Funding Source: FCT
FX This work was supported by Fundacao para a Ciencia e a Tecnologia (FCT)
   and COMPETE, QREN and FEDER (SFRH/BD/63086/2009).
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NR 69
TC 45
Z9 49
U1 0
U2 85
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0890-6238
J9 REPROD TOXICOL
JI Reprod. Toxicol.
PD NOV
PY 2014
VL 49
BP 196
EP 201
DI 10.1016/j.reprotox.2014.09.007
PG 6
WC Reproductive Biology; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Reproductive Biology; Toxicology
GA AT9PC
UT WOS:000345257900020
PM 25263228
DA 2025-06-11
ER

PT J
AU Semchyshyn, HM
AF Semchyshyn, H. M.
TI Fructation In Vivo: Detrimental and Protective Effects of
   Fructose
SO BIOMED RESEARCH INTERNATIONAL
LA English
DT Review
ID BOVINE SERUM-ALBUMIN; MAILLARD REACTION; OXIDATIVE STRESS; DIETARY
   FRUCTOSE; NONENZYMATIC GLYCATION; SUPEROXIDE-DISMUTASE; METABOLIC
   SYNDROME; DIABETES-MELLITUS; PROTEIN GLYCATION; CARBONYL STRESS
AB There is compelling evidence that long-term intake of excessive fructose can have deleterious side effects in different experimental models. However, the role of fructose in vivo remains controversial, since acute temporary application of fructose is found to protect yeast as well as animal tissues against exogenous oxidative stress. This review suggests the involvement of reactive carbonyl and oxygen species in both the cytotoxic and defensive effects of fructose. Potential mechanisms of the generation of reactive species by fructose in the nonenzymatic reactions, their implication in the detrimental and protective effects of fructose are discussed.
C1 Vassyl Stefanyk Precarpathian Natl Univ, Dept Biochem & Biotechnol, UA-76025 Ivano Frankivsk, Ukraine.
C3 Ministry of Education & Science of Ukraine; Vasyl Stefanyk Precarpathian
   National University
RP Semchyshyn, HM (corresponding author), Vassyl Stefanyk Precarpathian Natl Univ, Dept Biochem & Biotechnol, 57 Shevchenko St, UA-76025 Ivano Frankivsk, Ukraine.
EM semchyshyn@pu.if.ua
RI Semchyshyn, Halyna/AAW-1597-2021
OI Semchyshyn, Halyna/0000-0002-5967-2165
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NR 96
TC 46
Z9 49
U1 1
U2 12
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2314-6133
EI 2314-6141
J9 BIOMED RES INT
JI Biomed Res. Int.
PY 2013
VL 2013
AR 343914
DI 10.1155/2013/343914
PG 9
WC Biotechnology & Applied Microbiology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Research & Experimental Medicine
GA 194OR
UT WOS:000322643100001
PM 23984346
OA Green Published, Green Submitted, hybrid
DA 2025-06-11
ER

PT J
AU Araldi, E
   Suarez, Y
AF Araldi, Elisa
   Suarez, Yajaira
TI MicroRNAs as regulators of endothelial cell functions in cardiometabolic
   diseases
SO BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
LA English
DT Article
DE Endothelial cells; Metabolic syndrome; MicroRNAs; Atherosclerosis; Type
   2 diabetes; Cardiovascular disease
ID FLOW-DEPENDENT REGULATION; SMOOTH-MUSCLE-CELLS; IN-VIVO;
   CARDIOVASCULAR-DISEASE; INFLAMMATORY RESPONSE; GROWTH-FACTOR;
   SHEAR-STRESS; ANGIOGENIC RESPONSE; SIGNALING PATHWAYS;
   INSULIN-RESISTANCE
AB Endothelial cells (ECs) provide nutrients and oxygen essential for tissue homeostasis. Metabolic imbalances and other environmental stimuli, like cytokines or low shear stress, trigger endothelial inflammation, increase permeability, compromise vascular tone, promote cell proliferation, and ultimately cause cell death. These factors contribute to EC dysfunction, which is crucial in the development of cardiometabolic diseases. microRNAs (miRNAs) are small non-coding RNAs that have important functions in the regulation of ECs. In the present review, we discuss the role of miRNAs in various aspects of EC pathology in cardiometabolic diseases like atherosclerosis, type 2 diabetes, obesity, and the metabolic syndrome, and in complication of those pathologies, like ischemia. We also discuss the potential therapeutic applications of miRNAs in promoting angiogenesis and neovascularization in tissues where the endothelium is damaged in different cardiometabolic diseases. This article is part of a Special Issue entitled: MicroRNAs and lipid/energy metabolism and related diseases edited by Carlos Fernandez-Hernando and Yajaira Suarez. (C) 2016 Elsevier B.V. All rights reserved.
C1 Yale Univ, Sch Med, Program Integrat Cell Signaling & Neurobiol Metab, Sect Comparat Med,Dept Pathol, 10 Amistad St,Amistad Res Bldg 301-B, New Haven, CT 06520 USA.
   Yale Univ, Sch Med, Vasc Biol & Therapeut Program, 10 Amistad St,Amistad Res Bldg 301-B, New Haven, CT 06520 USA.
C3 Yale University; Yale University
RP Suarez, Y (corresponding author), Yale Univ, Sch Med, 10 Amistad St,Amistad Res Bldg 301-B, New Haven, CT 06520 USA.
EM yajaira.suarez@yale.edu
RI Araldi, Elisa/AAZ-5946-2021
OI Suarez, Yajaira/0000-0003-4549-2953; Araldi, Elisa/0000-0002-6596-6784
FU National Institutes of Health [R01HL105945]; American Heart Association
   [16GRNT26420047]; American Heart Association (AHA) [16GRNT26420047]
   Funding Source: American Heart Association (AHA)
FX The authors apologize to the many scientists whose contributions to the
   field could not be acknowledged owing to space limitations. YS
   laboratory is supported by grants from the National Institutes of Health
   (R01HL105945) and the American Heart Association (16GRNT26420047).
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NR 116
TC 43
Z9 45
U1 1
U2 12
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1388-1981
EI 1879-2618
J9 BBA-MOL CELL BIOL L
JI Biochim. Biophys. Acta Mol. Cell Biol. Lipids
PD DEC
PY 2016
VL 1861
IS 12
SI SI
BP 2094
EP 2103
DI 10.1016/j.bbalip.2016.01.013
PN B
PG 10
WC Biochemistry & Molecular Biology; Biophysics; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Cell Biology
GA ED0QD
UT WOS:000388546100009
PM 26825686
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Garay-Sevilla, ME
   Beeri, MS
   de la Maza, MP
   Rojas, A
   Salazar-Villanea, S
   Uribarri, J
AF Garay-Sevilla, M. E.
   Beeri, M. S.
   de la Maza, M. P.
   Rojas, A.
   Salazar-Villanea, S.
   Uribarri, J.
TI The potential role of dietary advanced glycation endproducts in the
   development of chronic non-infectious diseases: a narrative review
SO NUTRITION RESEARCH REVIEWS
LA English
DT Review
DE Glycation; Oxidative stress; Diabetes; Metabolic syndrome; CVD;
   Dementia; Sarcopenia
ID OXIDATION PROTEIN PRODUCTS; NF-KAPPA-B; CACO-2 CELL MONOLAYERS;
   END-PRODUCTS; ALZHEIMERS-DISEASE; ENDOTHELIAL FUNCTION; METABOLIC
   SYNDROME; DIABETES-MELLITUS; OXIDANT STRESS; EPSILON-CARBOXYMETHYLLYSINE
AB Increasing clinical and experimental evidence accumulated during the past few decades supports an important role for dietary advanced glycation endproducts (AGE) in the pathogenesis of many chronic non-infectious diseases, such as type 2 diabetes, CVD and others, that are reaching epidemic proportions in the Western world. Although AGE are compounds widely recognised as generated in excess in the body in diabetic patients, the potential importance of exogenous AGE, mostly of dietary origin, has been largely ignored in the general nutrition audience. In the present review we aim to describe dietary AGE, their mechanisms of formation and absorption into the body as well as their main mechanisms of action. We will present in detail current evidence of their potential role in the development of several chronic non-infectious clinical conditions, some general suggestions on how to restrict them in the diet and evidence regarding the potential benefits of lowering their consumption.
C1 [Garay-Sevilla, M. E.] Univ Guanajuato, Med Sci Dept, Guanajuato, Mexico.
   [Beeri, M. S.] Icahn Sch Med Mt Sinai, Dept Psychiat, New York, NY 10029 USA.
   [Beeri, M. S.] Sheba Med Ctr, Joseph Sagol Neurosci Ctr, Ramat Gan, Israel.
   [de la Maza, M. P.] Univ Chile, Inst Nutr & Food Technol Dr Fernando Monckeberg B, Santiago, Chile.
   [Rojas, A.] Catholic Univ Maule, Fac Med, Biomed Res Labs, Talca, Chile.
   [Salazar-Villanea, S.] Univ Costa Rica, Dept Anim Sci, San Jose, Costa Rica.
   [Uribarri, J.] Icahn Sch Med Mt Sinai, Dept Med, New York, NY 10029 USA.
C3 Universidad de Guanajuato; Icahn School of Medicine at Mount Sinai;
   Chaim Sheba Medical Center; Tel Aviv University; Universidad de Chile;
   Universidad Catolica del Maule; Universidad Costa Rica; Icahn School of
   Medicine at Mount Sinai
RP Uribarri, J (corresponding author), Icahn Sch Med Mt Sinai, Dept Med, New York, NY 10029 USA.
EM Jaime.uribarri@mountsinai.org
RI Uribarri, Jaime/ADX-7655-2022; Rojas, Armando/D-2647-2014
OI uribarri, jaime/0000-0001-9826-1134; Garay-Sevilla, Ma.
   Eugenia/0000-0002-6758-3197; Rojas, Armando/0000-0001-9911-7142; Salazar
   Villanea, Sergio/0000-0002-0332-6263
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   2008, AM J PHYSL, V294, pC145
NR 149
TC 36
Z9 37
U1 1
U2 38
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0954-4224
EI 1475-2700
J9 NUTR RES REV
JI Nutr. Res. Rev.
PD DEC
PY 2020
VL 33
IS 2
BP 298
EP 311
AR PII S0954422420000104
DI 10.1017/S0954422420000104
PG 14
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA OO9FQ
UT WOS:000587679400009
PM 32238213
DA 2025-06-11
ER

PT J
AU Benberin, VV
   Sibagatova, AS
   Nagimtayeva, AA
   Akhmetova, KM
   Voshchenkova, TA
AF Benberin, Valery V.
   Sibagatova, Ainur S.
   Nagimtayeva, Almagul A.
   Akhmetova, Kamshat M.
   Voshchenkova, Tamara A.
TI RETRACTED: Systematisation of biological protectors for managing the
   metabolic syndrome development (Retracted article. See MAY, 2023)
SO JOURNAL OF DIABETES AND METABOLIC DISORDERS
LA English
DT Article; Retracted Publication
DE Bioprotectors; Homeostasis; Cardiometabolic diseases; Regulation of
   homeostasis
ID HOMEOSTASIS
AB Background Metabolic syndrome (MS) is becoming a major health risk in the world. Disorders of homeostasis are a trigger for MS and subsequent cardiometabolic diseases (CMDs). Its physiological role can be supported by biological protectors (BP). The purpose of this study is to develop a BP system for managing the MS development. Methods Within the framework of the case-control study, 3000 participants aged 20-60 years formed 2 groups: the main group and the control group. Results The study compared traditional markers of oxidative stress, chronic inflammation, and insulin resistance, which reflect the state of homeostasis. The BP system, proposed based on the concept of maintaining homeostasis, offers the following points for investigating the possibilities of therapeutic intervention: confronting dysregulation of homeostasis, resisting chronic inflammation and oxidative stress, resisting the consequences of disturbed homeostasis. This approach not only contributed to the understanding of general biological processes, but also provided a targeted search and development of BP to maintain the stability of homeostasis with MS. Conclusions The study results provided insight into new opportunities in the MS management.
C1 [Benberin, Valery V.] Med Ctr Hosp Presidents Affairs Adm Republ Kazakh, Adm Dept, 80 Mangilik El Ave, Nur Sultan 010000, Kazakhstan.
   [Sibagatova, Ainur S.] Med Ctr Hosp Presidents Affairs Adm Republ Kazakh, Sect Clin Res, 80 Mangilik El Ave, Nur Sultan 010000, Kazakhstan.
   [Nagimtayeva, Almagul A.; Akhmetova, Kamshat M.; Voshchenkova, Tamara A.] Med Ctr Hosp Presidents Affairs Adm Republ Kazakh, Gerontol Ctr, 80 Mangilik El Ave, Nur Sultan 010000, Kazakhstan.
RP Benberin, VV (corresponding author), Med Ctr Hosp Presidents Affairs Adm Republ Kazakh, Adm Dept, 80 Mangilik El Ave, Nur Sultan 010000, Kazakhstan.
EM benberin5892@kpi.com.de
FU Committee of Science under the Ministry of Education and Science of the
   Republic of Kazakhstan [BR05236375]
FX The study was carried out within the framework of the technological
   programme BR05236375 "Study of the features concerning genetic risk of
   diseases associated with metabolic syndrome in the Kazakh population, by
   order of the State Institution " Committee of Science under the Ministry
   of Education and Science of the Republic of Kazakhstan".
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NR 23
TC 1
Z9 1
U1 0
U2 2
PU SPRINGER INT PUBL AG
PI CHAM
PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND
EI 2251-6581
J9 J DIABETES METAB DIS
JI J. Diabetes Metab. Disord.
PD DEC
PY 2021
VL 20
IS 2
BP 1449
EP 1454
DI 10.1007/s40200-021-00883-3
EA AUG 2021
PG 6
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA XE9GG
UT WOS:000691508000002
PM 34900796
OA Green Published
DA 2025-06-11
ER

PT J
AU Sferrazzo, G
   Palmeri, R
   Vanella, L
   Parafati, L
   Ronsisvalle, S
   Biondi, A
   Basile, F
   Li Volti, G
   Barbagallo, I
AF Sferrazzo, Giuseppe
   Palmeri, Rosa
   Vanella, Luca
   Parafati, Lucia
   Ronsisvalle, Simone
   Biondi, Antonio
   Basile, Francesco
   Li Volti, Giovanni
   Barbagallo, Ignazio
TI Mangifera indica L. Leaf Extract Induces Adiponectin and Regulates
   Adipogenesis
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE oxidative stress; metabolic syndrome; adipocyte; adiponectin; mangiferin
ID HIGH-FAT DIET; ADIPOSE-TISSUE; INSULIN SENSITIVITY; PPAR-GAMMA; OBESITY;
   MICE; MANGO; RESPONSES; HYPERLIPIDEMIA; CARDIOMYOPATHY
AB Natural bioactive compounds may be used in obese patients because of their ability to impact on various key mechanisms involved in the complex pathophysiological mechanisms of such condition. The aim of this study was to investigate the effect of a Mangifera indica L. leaf extract (MLE) on adipogenic differentiation of murine preadipocyte cells. 3T3-L1 cells were treated during their differentiation with various concentrations of (Mangifera indica L.) leaves extract (MLE) (750, 380, 150, 75 and 35 mu g) in order to assess their lipid content, adiponectin production, expression profile of genes involved in lipid metabolism, oxidative stress and inflammation. Our results showed that MLE was particularly enriched in polyphenols (46.30 +/- 0.083 mg/g) and that pharmacological treatment of cells resulted in a significant increase of adiponectin levels and reduction of intracellular lipid content. Consistently with these results, MLE resulted in a significant decrease of the expression of genes involved in lipid metabolism (FAS, PPARG, DGAT1, DGAT2, and SCD-1). In conclusion, our results suggest that MLE may represent a possible pharmacological tool for obese or metabolic syndrome patients.
C1 [Sferrazzo, Giuseppe; Vanella, Luca; Ronsisvalle, Simone; Barbagallo, Ignazio] Univ Catania, Dept Drug Sci, Biochem Sect, Viale A Doria 6, I-95125 Catania, Italy.
   [Palmeri, Rosa; Parafati, Lucia] Univ Catania, Dept Agr Food & Environm, Via S Sofia, I-95125 Catania, Italy.
   [Biondi, Antonio; Basile, Francesco] Univ Catania, Dept Gen Surg & Med Surg Specialties, Via S Sofia 87, I-95125 Catania, Italy.
   [Li Volti, Giovanni] Univ Catania, Dept Biomed & Biotechnol Sci, Via S Sofia 87, I-95125 Catania, Italy.
   [Li Volti, Giovanni] EuroMediterranean Inst Sci & Technol, Via Michele Miraglia 20, I-90139 Palermo, Italy.
C3 University of Catania; University of Catania; University of Catania;
   University of Catania
RP Li Volti, G (corresponding author), Univ Catania, Dept Biomed & Biotechnol Sci, Via S Sofia 87, I-95125 Catania, Italy.; Li Volti, G (corresponding author), EuroMediterranean Inst Sci & Technol, Via Michele Miraglia 20, I-90139 Palermo, Italy.
EM livolti@unict.it
RI parafati, lucia/ISB-1841-2023; Ronsisvalle, Simone/AAD-7995-2019; Volti,
   Giovanni/A-2435-2008; PALMERI, Rosa/AAK-6035-2020; Vanella,
   Luca/J-7354-2016; Biondi, Antonio/C-9190-2013
OI Vanella, Luca/0000-0002-6314-6029; Barbagallo,
   Ignazio/0000-0002-7761-0662; Basile, Francesco/0000-0001-6831-5840;
   PALMERI, Rosa/0000-0002-7660-5781; Parafati, Lucia/0000-0002-1228-4181;
   Li Volti, Giovanni/0000-0002-8678-2183; Biondi,
   Antonio/0000-0002-9374-779X
FU University of Catania
FX This work was supported by a grant from the University of Catania (FIR
   2016-2018, PI: Giovanni Li Volti).
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NR 50
TC 13
Z9 13
U1 0
U2 13
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD JUL 1
PY 2019
VL 20
IS 13
AR 3211
DI 10.3390/ijms20133211
PG 15
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA IL1EG
UT WOS:000477041100099
PM 31261958
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Rasgon, NL
   Kenna, HA
   Williams, KE
   Powers, B
   Wroolie, T
   Schatzberg, AF
AF Rasgon, Natalie L.
   Kenna, Heather A.
   Williams, Katherine E.
   Powers, Bevin
   Wroolie, Tonita
   Schatzberg, Alan F.
TI Rosiglitazone Add-On in Treatment of Depressed Patients with Insulin
   Resistance: a Pilot Study
SO THESCIENTIFICWORLDJOURNAL
LA English
DT Article
DE insulin resistance; depression; Matsuda Index; rosiglitazone
ID GLUCOSE-TOLERANCE; CARDIOVASCULAR-DISEASE; REPRODUCTIVE FUNCTION;
   AFFECTIVE-DISORDERS; METABOLIC SYNDROME; WOMEN; RISK; SENSITIVITY;
   SYMPTOMS
AB A number of cross-sectional studies have suggested an association between insulin resistance (IR) and affective disorders. However, limited data exist on potential changes in IR in a prospective treatment of depression. The present pilot study tested the hypothesis that improvement of IR with the addition of an insulin-sensitizing agent would improve mood in nondiabetic patients with unipolar or bipolar depression, who had surrogate blood markers suggestive of IR. Surrogate IR-criteria blood markers were fasting plasma glucose >100 mg/dl or triglyceride (TG) to high density lipoprotein (HDL) ratio >3.0. Open-label rosiglitazone, titrated to a dose of 8 mg/day, was administered for 12 weeks to 12 patients with depressive disorder receiving treatment as usual (TAU). Eight patients who completed the 12-week study exhibited significant declines in both depression severity by the Hamilton Depression Rating Scale and the Clinical Global Impression scale, with moderate effect sizes noted. Modest improvement in Matsuda Index scores was also noted at 12 weeks, yet declines in depression severity scores were not associated with improvements in the endocrine markers (Matsuda Index, TG/HDL ratio, and body mass index). These results suggest the potential novel use for an insulin-sensitizing agent in the treatment of depressive disorders. Larger placebocontrolled studies are warranted.
C1 [Rasgon, Natalie L.; Kenna, Heather A.; Williams, Katherine E.; Powers, Bevin; Wroolie, Tonita] Stanford Univ, Sch Med, Stanford Ctr Neurosci Womens Hlth, Stanford, CA 94305 USA.
   [Schatzberg, Alan F.] Stanford Univ, Sch Med, Dept Psychiat & Behav Sci, Mood Disorders Program, Stanford, CA USA.
C3 Stanford University; Stanford University
RP Rasgon, NL (corresponding author), Stanford Univ, Sch Med, Stanford Ctr Neurosci Womens Hlth, Stanford, CA 94305 USA.
EM nrasgon@stanford.edu; hkenna@stanford.edu; elliew@stanford.edu;
   bnpowers@stanford.edu; twroolie@stanford.edu; afschatz@stanford.edu
RI Rasgon, Natalie/ABH-9813-2020
FU National Center for Research Resources, National Institutes of Health
   [M01 RR-00070]
FX This study was supported in part by grant M01 RR-00070 from the National
   Center for Research Resources, National Institutes of Health.
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NR 36
TC 82
Z9 91
U1 0
U2 2
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1537-744X
J9 THESCIENTIFICWORLDJO
JI TheScientificWorldJOURNAL
PY 2010
VL 10
BP 321
EP 328
DI 10.1100/tsw.2010.32
PG 8
WC Environmental Sciences; Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Science & Technology - Other Topics
GA 560WL
UT WOS:000274935000007
PM 20191245
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Ostrov, I
   Gong, YJ
   Zuk, JB
   Wickramasinghe, PCK
   Tmenova, I
   Roopchand, DE
   Zhao, LP
   Raskin, I
AF Ostrov, Ievgeniia
   Gong, Yongjia
   Zuk, Joshua B.
   Wickramasinghe, Purni C. K.
   Tmenova, Irina
   Roopchand, Diana E.
   Zhao, Liping
   Raskin, Ilya
TI Elemental iron protects gut microbiota against oxygen-induced dysbiosis
SO PLOS ONE
LA English
DT Article
ID OXIDATIVE STRESS; AKKERMANSIA-MUCINIPHILA; METABOLIC SYNDROME;
   PATHOGENESIS; HEALTH; CROSSTALK; DISEASES; TISSUE; MODEL; DIET
AB Gut dysbiosis induced by oxygen and reactive oxygen species may be related to the development of inflammation, resulting in metabolic syndrome and associated-conditions in the gut. Here we show that elemental iron can serve as an antioxidant and reverse the oxygen-induced dysbiosis. Fecal samples from three healthy donors were fermented with elemental iron and/or oxygen. 16S rRNA analysis revealed that elemental iron reversed the oxygen-induced disruption of Shannon index diversity of the gut microbiota.The bacteria lacking enzymatic antioxidant systems also increased after iron treatment. Inter-individual differences, which corresponded to iron oxidation patterns, were observed for the tested donors. Gut bacteria responding to oxygen and iron treatments were identified as guilds, among which, Escherichia-Shigella was promoted by oxygen and depressed by elemental iron, while changes in bacteria such as Bifidobacterium, Blautia, Eubacterium, Ruminococcaceae, Flavonifractor, Oscillibacter, and Lachnospiraceae were reversed by elemental iron after oxygen treatment. Short-chain fatty acid production was inhibited by oxygen and this effect was partially reversed by elemental iron. These results suggested that elemental iron can regulate the oxygen/ROS state and protect the gut microbiota from oxidative stress.
C1 [Ostrov, Ievgeniia; Zuk, Joshua B.; Tmenova, Irina; Raskin, Ilya] Rutgers State Univ, Sch Environm & Biol Sci, Dept Plant Biol, New Brunswick, NJ 08854 USA.
   [Gong, Yongjia; Wickramasinghe, Purni C. K.; Roopchand, Diana E.] Rutgers State Univ, Sch Environm & Biol Sci, Dept Food Sci, New Brunswick, NJ USA.
   [Zhao, Liping] Rutgers State Univ, Sch Environm & Biol Sci, Dept Biochem & Microbiol, New Brunswick, NJ USA.
C3 Rutgers University System; Rutgers University New Brunswick; Rutgers
   University System; Rutgers University New Brunswick; Rutgers University
   System; Rutgers University New Brunswick
RP Raskin, I (corresponding author), Rutgers State Univ, Sch Environm & Biol Sci, Dept Plant Biol, New Brunswick, NJ 08854 USA.
EM raskin@rutgers.edu
RI Zhao, Liping/AEA-4833-2022
OI Raskin, Ilya/0000-0002-3025-8112
FU U.S.-Israel Binational Agricultural Research and Development Fund (BARD)
   (Vaadia-BARD Postdoctoral Fellowship) [Fl-580-2018]; NIH / NCCIH
   Postdoctoral Training Grant [5T32AT004094]; NIH / ODS / NCCIH Botanical
   Center Grant [P50 AT002776]
FX <STRONG> </STRONG>This work was supported by the U.S.-Israel Binational
   Agricultural Research and Development Fund (BARD) (Vaadia-BARD
   Postdoctoral Fellowship Proposal No. Fl-580-2018 to I.O.), the NIH /
   NCCIH Postdoctoral Training Grant (5T32AT004094 to J.B.Z.), and by NIH /
   ODS / NCCIH Botanical Center Grant (P50 AT002776 to I.R.). The funders
   had no role in study design, data collection and analysis, decision to
   publish, or preparation of the manuscript.
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NR 65
TC 0
Z9 0
U1 2
U2 3
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD FEB 27
PY 2024
VL 19
IS 2
AR e0298592
DI 10.1371/journal.pone.0298592
PG 18
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA MV9G9
UT WOS:001196523000040
PM 38412144
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Beltrame, JF
   Crea, F
   Camici, P
AF Beltrame, John F.
   Crea, Filippo
   Camici, Paolo
TI Advances in Coronary Microvascular Dysfunction
SO HEART LUNG AND CIRCULATION
LA English
DT Article; Proceedings Paper
CT 56th Annual Scientific Meeting of the
   Cardiac-Society-of-Australia-and-New-Zealand
CY AUG 07-10, 2008
CL Adelaide, AUSTRALIA
SP Cardiac Soc Australia & New Zealand
DE Microcirculation; Syndrome X; Coronary flow reserve; Coronary heart
   disease
ID MYOCARDIAL BLOOD-FLOW; CONVERTING ENZYME-INHIBITION; EXERCISE-INDUCED
   ANGINA; ST-SEGMENT DEPRESSION; CARDIAC SYNDROME-X; CHEST-PAIN;
   ARTERY-DISEASE; VASODILATOR RESERVE; PECTORIS; ISCHEMIA
AB Considerable focus has been directed towards coronary arterial disease in the management of coronary heart disease, however the coronary microcirculation plays a major role in the regulation of coronary blood flow. Thus while we have multiple medical and revascularisation therapies to treat large vessel coronary artery disease, therapies directed towards the microcirculation are very limited.
   This review paper summarises important aspects of coronary microvascular dysfunction including (a) methods of assessment, (b) clinical classification of associated disorders, (c) possible pathophysiological mechanisms, and (d) potential therapies. Hence this will provide important background to advancing our understanding and management of coronary heart disease by targeting the coronary microcirculation.
C1 [Beltrame, John F.] Univ Adelaide, Cardiol Unit, Queen Elizabeth Hosp, Lyell McEwin Hlth Serv, Adelaide, SA, Australia.
   [Crea, Filippo] Univ Cattolica Sacro Cuore, Inst Cardiol, I-00168 Rome, Italy.
   [Camici, Paolo] Univ London Imperial Coll Sci Technol & Med, Ctr Clin Sci, London, England.
   [Camici, Paolo] Univ London Imperial Coll Sci Technol & Med, NHLI, London, England.
C3 University of Adelaide; Lyell McEwin Hospital; Catholic University of
   the Sacred Heart; IRCCS Policlinico Gemelli; Imperial College London;
   Imperial College London
RP Beltrame, JF (corresponding author), Queen Elizabeth Hosp, Cardiol Unit, 28 Woodville Rd, Woodville, SA 5011, Australia.
EM john.beltrame@adelaide.edu.au
RI Camici, Paolo/AAN-1959-2020; Crea, Filippo/AAC-9754-2022; Beltrame,
   John/C-1687-2017
FU MRC [MC_U120084164] Funding Source: UKRI
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NR 80
TC 50
Z9 54
U1 1
U2 16
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1443-9506
EI 1444-2892
J9 HEART LUNG CIRC
JI Heart Lung Circ.
PD FEB
PY 2009
VL 18
IS 1
BP 19
EP 27
DI 10.1016/j.hlc.2008.11.002
PG 9
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Cardiovascular System & Cardiology
GA 414LY
UT WOS:000263866500005
PM 19119077
DA 2025-06-11
ER

PT J
AU Folchetti, LD
   Monfort-Pires, M
   de Barros, CR
   Martini, LA
   Ferreira, SRG
AF Folchetti, Luciana Dias
   Monfort-Pires, Milena
   de Barros, Camila R.
   Martini, Ligia Araujo
   Gouvea Ferreira, Sandra Roberta
TI Association of fruits and vegetables consumption and related-vitamins
   with inflammatory and oxidative stress markers in prediabetic
   individuals
SO DIABETOLOGY & METABOLIC SYNDROME
LA English
DT Article
DE Fruits and vegetables; Vitamins; Oxidative stress; Insulin resistance;
   Inflammation
ID NUTRITION EXAMINATION SURVEY; METABOLIC SYNDROME;
   CARDIOVASCULAR-DISEASE; DIETARY-INTAKE; NATURAL ANTIOXIDANTS;
   NATIONAL-HEALTH; YOUNG-ADULTS; US ADULTS; RISK; METAANALYSIS
AB Background: Dietary guidelines of 5 servings per day of fruits and vegetables (FV) offer a reasonable amount of vitamins to control organic processes, which may contribute to a favorable cardiometabolic profile. This study aimed at investigating whether the intake of the FV group as well as pro-vitamin A carotenoids and vitamins C and E were associated with circulating markers of oxidative stress, inflammation and insulin resistance in Brazilians individuals at cardiometabolic risk.
   Methods: This cross-sectional study included 205 individuals screened for diabetes prevention program in a healthcare center from the School of Public Health, University of Sao Paulo, conducted in 2008. Possible associations of consumption of FV group, as well as pro-vitamin A carotenoids and vitamins C and E, with circulating markers of oxidative stress (superoxide dismutase - SOD and oxidized LDL - oxLDL), inflammation (C reactive protein, TNF-alpha and adiponectin) and insulin resistance (HOMA-IR) were investigated. Pearson correlation coefficient, ANOVA and multiple linear regression were employed.
   Results: The sample (64.7% women) had a mean age of 54.1 +/- 12.7 years and body mass index of 30.7 +/- 5.7 kg/m2. Dietary, physical activity, anthropometric and laboratory data were obtained. Participants consumed a mean of 3.8 servings/day of FV; their FV intake was categorized into three groups: < 2.5, 2.5-5.0 and >5.0 servings/day. Significant trends for lower waist circumference (103.4 +/- 13.6 vs. 100.1 +/- 12.2 vs. 98.2 +/- 12.7 cm, p-trend < 0.05) and higher adiponectin concentrations (10.4 +/- 1.8 vs. 11.9 +/- 1.9 vs. 13.6 +/- 2.1 ng/mL, p-trend <0.05) were detected across categories. Associations between SOD concentrations (beta 0.172 [ 0.110-0.688]) with FV consumption and between oxLDL concentrations with vitamins C (beta -0.333 [-2.568 - -0.218]) and E (beta -0.354 [-1.131- -0.110]) intakes, adjusted for age, gender, BMI, saturated fat intake, smoking and physical activity were found. Similar results were observed for the associations between oxLDL and FV intake, but significance disappeared adding adjustment for saturated fat, smoking and physical activity.
   Conclusion: Our data suggest that the intake of FV or selected vitamins may be useful for identifying the oxidative stress and inflammation involved in the genesis of cardiometabolic diseases and for motivating at-risk patients for changing dietary habits.
C1 [Folchetti, Luciana Dias; Monfort-Pires, Milena; de Barros, Camila R.; Martini, Ligia Araujo; Gouvea Ferreira, Sandra Roberta] Univ Sao Paulo, Fac Saude Publ, Dept Nutr, BR-01246904 Sao Paulo, Brazil.
C3 Universidade de Sao Paulo
RP Ferreira, SRG (corresponding author), Univ Sao Paulo, Fac Saude Publ, Dept Nutr, Av Dr Arnaldo 715, BR-01246904 Sao Paulo, Brazil.
EM sandrafv@usp.br
RI Martini, Ligia/C-7279-2012; Folchetti, Luciana/B-2597-2016; Ferreira,
   Sandra/B-9840-2012; Stefanadis, Christodoulos/ABH-2232-2020
OI Stefanadis, Christodoulos/0000-0001-5974-6454; Monfort-Pires,
   Milena/0000-0002-1652-8083; Ferreira, Sandra/0000-0002-7015-7391; Araujo
   Martini, Ligia/0000-0001-8409-2907
FU Sao Paulo Foundation for Research Support - FAPESP; Coordination for
   Improvement of Graduate Personnel - CAPES (Brazil)
FX This work was supported by a grant from The Sao Paulo Foundation for
   Research Support - FAPESP and from Coordination for Improvement of
   Graduate Personnel - CAPES (Brazil).
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NR 44
TC 22
Z9 25
U1 0
U2 20
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1758-5996
J9 DIABETOL METAB SYNDR
JI Diabetol. Metab. Syndr.
PD FEB 18
PY 2014
VL 6
AR 22
DI 10.1186/1758-5996-6-22
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA AB9HW
UT WOS:000332103600001
PM 24548603
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Kalra, S
   Kumar, KVSH
AF Kalra, Sanjay
   Kumar, K. V. S. Hari
TI Seven Sinful Sisters: Seven Smart Solutions to Stop Diabetes
SO JOURNAL OF THE PAKISTAN MEDICAL ASSOCIATION
LA English
DT Article
DE Diabetes; hypertension; metabolic syndrome; obesity; prevention; public
   health; salutogenesis
AB This article describes a Seven Sinful Sisters and Smart Solutions (FIVE S) concept, which lists seven contributory factors of diabetes, and seven potential solutions to help prevent its spread. The Seven Sinful Sisters include Sugar, Salt, Saturated fat, Spirits (alcohol), Sitting time (sedentary life style), Steroids (including other drugs) and Stress. Seven Smart salutogenic Solutions are use of Self-restraint, Small size portions, Spices (nutrition -based remedies, including sugar and salt substitutes), Slimnastics (a synonym for aerobic exercise), high Spirit (a positive attitude), health Sleep/Siesta, and enjoyment of Sunday (or Stress management).
C1 [Kalra, Sanjay] Bharti Hosp, Dept Endocrinol, Karnal, India.
   [Kumar, K. V. S. Hari] R&R Hosp, Dept Endocrinol, New Delhi, India.
RP Kalra, S (corresponding author), Bharti Hosp, Dept Endocrinol, Karnal, India.
EM brideknl@gmail.com
CR Page-Reeves J, 2013, QUAL REP, V18
   Sharma R, 2017, J SOC HLTH DIABETES, V5, P12
   Tunceli K, 2005, DIABETES CARE, V28, P2662, DOI 10.2337/diacare.28.11.2662
NR 3
TC 1
Z9 1
U1 0
U2 3
PU PAKISTAN MEDICAL ASSOC
PI KARACHI
PA PMA HOUSE, AGA KHAN III RD, KARACHI, 00000, PAKISTAN
SN 0030-9982
J9 J PAK MED ASSOC
JI J. Pak. Med. Assoc.
PD NOV
PY 2018
VL 68
IS 11
BP 1727
EP 1728
PG 2
WC Medicine, General & Internal; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Research & Experimental Medicine
GA HC8BN
UT WOS:000452026500036
PM 30410162
DA 2025-06-11
ER

PT J
AU Petta, S
   Muratore, C
   Craxì, A
AF Petta, S.
   Muratore, C.
   Craxi, A.
TI Non-alcoholic fatty liver disease pathogenesis: The present and the
   future
SO DIGESTIVE AND LIVER DISEASE
LA English
DT Review
DE Insulin resistance; Non-alcoholic fatty liver disease; Non-alcoholic
   steatohepatitis; Steatosis
ID ACTIVATED-RECEPTOR-ALPHA; CHRONIC HEPATITIS-C; TRIGLYCERIDE TRANSFER
   PROTEIN; ENDOPLASMIC-RETICULUM STRESS; NECROSIS-FACTOR-ALPHA;
   NF-KAPPA-B; INSULIN-RESISTANCE; METABOLIC SYNDROME; OXIDATIVE-STRESS;
   ANGIOTENSIN-II
AB Non-alcoholic fatty liver disease is the clinical hepatic expression of metabolic syndrome. The prevalence of non-alcoholic fatty liver disease is around 20-30%, and with a rapid increase in the metabolic risk factors in the general population, non-alcoholic fatty liver disease has become the most common cause of liver disease worldwide. A fraction (20-30%) of non-alcoholic fatty liver disease patients develop a potentially progressive hepatic disorder, namely non-alcoholic steatohepatitis, leading to end-stage liver disease. The pathogenesis of non-alcoholic fatty liver disease is not entirely understood, and even if insulin resistance is a major pathogenetic key, many other factors are implicated in both liver fat accumulation and disease progression to non-alcoholic steatohepatitis. In this review we aim to examine the literature, principally concerning human non-alcoholic fatty liver disease pathogenesis, and to identify the newest, most promising clinical and basic research data. (C) 2009 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.
C1 [Petta, S.; Craxi, A.] Univ Palermo, Di Bi MIS, Cattedra & Unita Operat Gastroenterol, Palermo, Italy.
   [Muratore, C.] Univ Palermo, Dipartimento Materno Infantile, Div Neuropsichiatria Infantile, Palermo, Italy.
C3 University of Palermo; University of Palermo
RP Petta, S (corresponding author), Piazza Clin 2, I-90127 Palermo, Italy.
EM petsa@inwind.it
RI ; Craxi, Antonio/K-9529-2016
OI Petta, Salvatore/0000-0002-0822-9673; Craxi, Antonio/0000-0002-4480-9544
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NR 208
TC 212
Z9 237
U1 7
U2 79
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1590-8658
EI 1878-3562
J9 DIGEST LIVER DIS
JI Dig. Liver Dis.
PD SEP
PY 2009
VL 41
IS 9
BP 615
EP 625
DI 10.1016/j.dld.2009.01.004
PG 11
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 493JG
UT WOS:000269732100001
PM 19223251
DA 2025-06-11
ER

PT J
AU Charlton, RA
   McQuaid, GA
   Bishop, L
   Wallace, GL
AF Charlton, Rebecca A.
   McQuaid, Goldie A.
   Bishop, Lauren
   Wallace, Gregory L.
TI Cardiovascular risk and emotion regulation contribute to depression
   symptomatology in middle-aged and older autistic adults
SO RESEARCH IN AUTISM SPECTRUM DISORDERS
LA English
DT Article
DE Ageing; Autism; Cardiovascular risk factors; Depression; Emotion
   regulation; Later-life; Physical health
ID QUALITY-OF-LIFE; METABOLIC SYNDROME; EXECUTIVE FUNCTION; SPECTRUM
   DISORDER; MAJOR DEPRESSION; VASCULAR RISK; YOUNG-ADULTS; HEALTH;
   DISEASE; ASSOCIATIONS
AB Background: Cardiovascular risk factors (CVRF) and executive function difficulties increase during later-life and are associated with depression symptoms among non-autistic older people. These associations, however, have not yet been explored among middle-aged and older autistic people.Methods: Using data collected via Simons Foundation Powering Autism Research (SPARK), Research Match, we examined the frequency of CVRF, and associations between CVRF, executive function and depression symptoms in 387 middle-aged and older autistic people (aged 40-83 years).Results: Autistic adults reported high rates of CVRF (two, 28.9%; three or more, 23.2%). Rates of high cholesterol and obesity were greater among middle-aged and older autistic adults compared to the general population. CVRF, age, and emotion regulation (but not inhibitory control), were significantly associated with depression symptoms in middle-aged and older autistic adults.Conclusions: CVRF occur at high rates in middle-aged and older autistic adults, and it is important that healthcare providers monitor risk factors in order to implement preventative strategies. CVRF are associated with depressive symptoms among middle-aged and older autistic adults, but may not be as important as difficulties with emotion regulation.
C1 [Charlton, Rebecca A.] Goldsmiths Univ London, Dept Psychol, London, England.
   [McQuaid, Goldie A.] George Mason Univ, Dept Psychol, Fairfax, VA USA.
   [Bishop, Lauren] Univ Wisconsin Madison, Sandra Rosenbaum Sch Social Work, Madison, WI USA.
   [Bishop, Lauren] Univ Wisconsin Madison, Waisman Ctr, Madison, WI USA.
   [Wallace, Gregory L.] George Washington Univ, Dept Speech Language & Hearing Sci, Fairfax, VA USA.
   [Charlton, Rebecca A.] Goldsmiths Univ London, Dept Psychol, London SE14 6NW, England.
C3 University of London; Goldsmiths University London; George Mason
   University; University of Wisconsin System; University of Wisconsin
   Madison; University of Wisconsin System; University of Wisconsin
   Madison; George Washington University; University of London; Goldsmiths
   University London
RP Charlton, RA (corresponding author), Goldsmiths Univ London, Dept Psychol, London SE14 6NW, England.
EM r.charlton@gold.ac.uk
RI Bishop, Lauren/AAH-5691-2021; Wallace, Gregory/H-2158-2018
OI Bishop, Lauren/0000-0003-1269-4129; McQuaid, Goldie/0000-0003-3614-616X;
   Wallace, Gregory/0000-0003-0329-5054
FU George Washington University [11808]; Fulbright Visiting Scholar
   program; Eunice Kennedy Shriver National Institute of Child Health and
   Human Development [U54HD090256]
FX The author (s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: The George
   Washington University start-up funds to Gregory Wallace; Autism Speaks
   (Grant number: 11808) to Goldie McQuaid; the Fulbright Visiting Scholar
   program to Rebecca Charlton; and the Eunice Kennedy Shriver National
   Institute of Child Health and Human Development (Grant number:
   U54HD090256) to the Waisman Center.
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NR 57
TC 4
Z9 4
U1 1
U2 8
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 1750-9467
EI 1878-0237
J9 RES AUTISM SPECT DIS
JI Res. Autism Spectr. Disord.
PD MAR
PY 2023
VL 101
AR 102089
DI 10.1016/j.rasd.2022.102089
EA DEC 2022
PG 9
WC Education, Special; Psychology, Developmental; Psychiatry;
   Rehabilitation
WE Social Science Citation Index (SSCI)
SC Education & Educational Research; Psychology; Psychiatry; Rehabilitation
GA 7O4CJ
UT WOS:000907973200001
OA Green Submitted, Green Accepted, hybrid
DA 2025-06-11
ER

PT J
AU Jiménez-Osorio, AS
   González-Reyes, S
   Pedraza-Chaverri, J
AF Sarai Jimenez-Osorio, Angelica
   Gonzalez-Reyes, Susana
   Pedraza-Chaverri, Jose
TI Natural Nrf2 activators in diabetes
SO CLINICA CHIMICA ACTA
LA English
DT Review
DE Prediabetes; Diabetes; Nrf2; Curcumin; Sulforaphane; Resveratrol;
   Vitamin D; Heme-oxygenase-1; Glutathione reductase; Glutathione
   peroxidase; Gamma-glutamate-cysteine ligase
ID VITAMIN-D SUPPLEMENTATION; LIFE-STYLE INTERVENTION; IMPAIRED
   GLUCOSE-TOLERANCE; INDUCED INSULIN-RESISTANCE; UP-REGULATES NRF2;
   OXIDATIVE STRESS; DOUBLE-BLIND; RESVERATROL SUPPLEMENTATION; ENDOTHELIAL
   FUNCTION; METABOLIC SYNDROME
AB Prediabetes and diabetes are rising worldwide. Control of blood glucose is crucial to prevent or delay diabetic complications that frequently result in increased morbidity and mortality. Most strategies include medical treatment and changes in lifestyle and diet. Some nutraceutical compounds have been recognized as adjuvants in diabetes control. Many of them can activate the nuclear factor (erythroid-derived 2)-like 2 (Nrf2), which has been recognized as a master regulator of the antioxidant response. Recent studies have described the role of Nrf2 in obesity, metabolic syndrome, nephropathy, retinopathy and neuropathy, where its activation prevents the development of diabetes and its complications. It has been demonstrated that natural compounds derived from plants, vegetables, fungi and micronutrients (such as curcumin, sulforaphane, resveratrol and vitamin D among others) can activate Nrf2 and, thus, promote antioxidant pathways to mitigate oxidative stress and hyperglycemic damage. The role of some natural Nrf2 activators and its effect in diabetes is discussed. (C) 2015 Elsevier B.V. All rights reserved.
C1 [Sarai Jimenez-Osorio, Angelica; Gonzalez-Reyes, Susana; Pedraza-Chaverri, Jose] Univ Nacl Autonoma Mexico, Dept Biol, Fac Chem, Univ City 04510, DF, Mexico.
C3 Universidad Nacional Autonoma de Mexico
RP Pedraza-Chaverri, J (corresponding author), Univ Nacl Autonoma Mexico, Dept Biol, Fac Chem, Univ City 04510, DF, Mexico.
EM joas17@hotmail.com; suxan05@gmail.com; pedraza@unam.mx
RI Jiménez-Osorio, Angélica/X-7119-2019
OI Jimenez-Osorio, Angelica Sarai/0000-0001-5108-0205; Gonzalez-Reyes,
   Susana/0000-0003-2260-8415
FU Consejo Nacional de Ciencia y Tecnologia (CONACYT)
   [SALUD-2013-01-201519, 252008]
FX This projeet was supported by Consejo Nacional de Ciencia y Tecnologia
   (CONACYT, Grant numbers SALUD-2013-01-201519 and 252008).
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NR 148
TC 114
Z9 121
U1 1
U2 65
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0009-8981
EI 1873-3492
J9 CLIN CHIM ACTA
JI Clin. Chim. Acta
PD AUG 25
PY 2015
VL 448
BP 182
EP 192
DI 10.1016/j.cca.2015.07.009
PG 11
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA CQ8OZ
UT WOS:000360869300030
PM 26165427
DA 2025-06-11
ER

PT J
AU Assies, J
   Mocking, RJT
   Lok, A
   Koeter, MWJ
   Bockting, CLH
   Visser, I
   Pouwer, F
   Ruhé, HG
   Schene, AH
AF Assies, Johanna
   Mocking, Roel J. T.
   Lok, Anja
   Koeter, Maarten W. J.
   Bockting, Claudi L. H.
   Visser, Ieke
   Pouwer, Francois
   Ruhe, Henricus G.
   Schene, Aart H.
TI Erythrocyte fatty acid profiles and plasma homocysteine, folate and
   vitamin B6 and B12 in recurrent depression:
   Implications for co-morbidity with cardiovascular disease
SO PSYCHIATRY RESEARCH
LA English
DT Article
DE Polyunsaturated fatty acids; Chain length; Unsaturation index;
   Peroxidation index; One-carbon cycle; Cardiovascular disease; Oxidative
   stress
ID CORONARY-HEART-DISEASE; DOCOSAHEXAENOIC ACID; OXIDATIVE STRESS;
   METABOLIC SYNDROME; N-3; OMEGA-3-FATTY-ACIDS; DISORDER; RISK;
   HYPERHOMOCYSTEINEMIA; POLYMORPHISM
AB Oxidative stress induced interactions between fatty acid (FA) and one-carbon metabolism may be involved in co-occurrence of major depressive disorder (MDD) and cardiovascular disease (CVD), which have been scarcely studied together. In 137 recurrent MDD-patients vs. 73 age- and sex-matched healthy controls, we simultaneously measured key components of one-carbon metabolism in plasma (homocysteine, folate, vitamins B-6 and B-12), and of FA-metabolism in red blood cell membranes [main polyunsaturated fatty acids (PUFAs) eicosapentaenoic acid (EPA), docosahexaenoic acid (DMA), and arachidonic acid (AA) and structural FA-indices (chain length, unsaturation, peroxidation)]. Results show significant positive associations of folate with EPA, DHA, and the peroxidation index, which were similar in patients and controls. After correction for confounders, these associations were lost except for EPA. Associations between B-vitamins and FA-parameters were non-significant, but also similar in patients and controls. Homocysteine and DHA were significantly less negatively associated in patients than in controls. In conclusion, these data indicate similarities but also differences in associations between parameters of one-carbon and FA-metabolism in recurrent MDD patients vs. controls, which may reflect differences in handling of oxidative stress. Further research should test the consequences of these differences, particularly the premature development of CVD in MDD. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
C1 [Assies, Johanna; Mocking, Roel J. T.; Lok, Anja; Koeter, Maarten W. J.; Visser, Ieke; Ruhe, Henricus G.; Schene, Aart H.] Univ Amsterdam, Acad Med Ctr, Dept Psychiat, Program Mood Disorders, NL-1105 AZ Amsterdam, Netherlands.
   [Lok, Anja] Arq Psychotrauma Expert Grp, Diemen, Netherlands.
   [Bockting, Claudi L. H.] Univ Groningen, Dept Clin Psychol, Groningen, Netherlands.
   [Bockting, Claudi L. H.] Univ Utrecht, Dept Clin & Hlth Psychol, Utrecht, Netherlands.
   [Pouwer, Francois] Tilburg Univ, Dept Med & Clin Psychol, Ctr Res Psychol Somat Dis CoRPS, NL-5000 LE Tilburg, Netherlands.
   [Ruhe, Henricus G.] Univ Groningen, Univ Med Ctr Groningen, Univ Ctr Psychiat, Program Mood & Anxiety Disorders, NL-9700 AB Groningen, Netherlands.
   [Schene, Aart H.] Radboud Univ Nijmegen Med Ctr, Dept Psychiat, Nijmegen, Netherlands.
   [Schene, Aart H.] Radboud Univ Nijmegen Med Ctr, Donders Inst Brain Cognit & Behav, Nijmegen, Netherlands.
C3 University of Amsterdam; Academic Medical Center Amsterdam; Arq
   Psychotrauma Expert Group; University of Groningen; Utrecht University;
   Tilburg University; University of Groningen; Radboud University
   Nijmegen; Radboud University Nijmegen
RP Assies, J (corresponding author), Univ Amsterdam, Acad Med Ctr, Dept Psychiat, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands.
EM j.assies@amc.uva.nl
RI Bockting, Claudi/K-3768-2019; Ruhe, Henricus/K-8764-2012; Schene,
   A.H./H-8085-2014; Mocking, Roel/H-8131-2012
OI Mocking, Roel/0000-0003-3543-3810; Pouwer, Frans/0000-0002-8172-9818;
   Bockting, Claudi L.H./0000-0002-9220-9244
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NR 69
TC 13
Z9 13
U1 0
U2 27
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0165-1781
J9 PSYCHIAT RES
JI Psychiatry Res.
PD OCT 30
PY 2015
VL 229
IS 3
BP 992
EP 998
DI 10.1016/j.psychres.2015.06.025
PG 7
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA CS5TN
UT WOS:000362141300047
PM 26260568
OA Green Published
DA 2025-06-11
ER

PT J
AU Bulka, CM
   Persky, VW
   Daviglus, ML
   Durazo-Arvizu, RA
   Argos, M
AF Bulka, Catherine M.
   Persky, Victoria W.
   Daviglus, Martha L.
   Durazo-Arvizu, Ramon A.
   Argos, Maria
TI Multiple metal exposures and metabolic syndrome: A cross-sectional
   analysis of the National Health and Nutrition Examination Survey
   2011-2014
SO ENVIRONMENTAL RESEARCH
LA English
DT Article
DE Toxic metals; Essential metals; Metabolic syndrome; Epidemiology
ID BLOOD LEAD LEVEL; SERUM SELENIUM; PRESSURE; ASSOCIATION; MERCURY;
   WEIGHT; ZINC; POPULATION; PREVALENCE; ELEMENTS
AB Background: Epidemiologic studies suggest toxic metals are linked with diabetes and cardiovascular disease, while experimental studies indicate nutritionally essential metals are involved in the metabolism of macro nutrients and defense against oxidative stress.
   Objectives: We sought to evaluate how essential and toxic metals are cross-sectionally related to metabolic syndrome, a clustering of cardiometabolic conditions.
   Methods: Using data from the 2011-2014 National Health and Nutrition Examination Survey (n = 1088), we characterized metal concentrations as measured in spot urine (arsenic, cadmium, and inorganic/elemental mercury), whole blood (manganese, lead, methylmercury, and selenium), and serum (copper and zinc) samples. Principal component analysis was performed to derive patterns of exposures. Metabolic syndrome was defined according to the 2009 Joint Scientific Statement as the presence of >= 3 of the following conditions: high blood pressure, high triglycerides, low HDL cholesterol, high fasting glucose, and abdominal obesity.
   Results: After adjustment for potential confounders, prevalence ratios for metabolic syndrome comparing the highest to the lowest quartiles were 1.41 (95% CI: 1.18-1.67) for the arsenic-inorganic/elemental mercury pattern, 0.95 (0.78-1.16) for the methylmercury-manganese pattern, 0.73 (0.57-0.94) for the cadmium-lead pattern, 0.91 (0.76-1.10) for the copper pattern, and 1.36 (1.13-1.63) for the selenium-zinc pattern. The positive associations observed for the arsenic-inorganic/elemental mercury pattern were due to an elevated prevalence of high blood pressure, low HDL cholesterol, and high triglycerides among those with greater exposures. Associations for the selenium-zinc pattern were driven by a positive relationship with high triglycerides. Greater lead-cadmium co-exposures were related to a lower prevalence of dyslipidemia and abdominal obesity.
   Conclusions: These cross-sectional findings suggest both toxic and essential metal exposures may contribute to cardiometabolic health, but need to be confirmed with prospective data.
C1 [Bulka, Catherine M.; Persky, Victoria W.; Argos, Maria] Univ Illinois, Sch Publ Hlth, Div Epidemiol & Biostat, 1603 W Taylor St, Chicago, IL 60612 USA.
   [Daviglus, Martha L.; Durazo-Arvizu, Ramon A.] Univ Illinois, Coll Med, Inst Minor Hlth Res, Chicago, IL USA.
C3 University of Illinois System; University of Illinois Chicago;
   University of Illinois Chicago Hospital; University of Illinois System;
   University of Illinois Chicago; University of Illinois Chicago Hospital
RP Bulka, CM (corresponding author), Univ Illinois, Sch Publ Hlth, Div Epidemiol & Biostat, 1603 W Taylor St, Chicago, IL 60612 USA.
EM cbulka2@uic.edu
FU National Heart, Lung, and Blood Institute (NHLBI) [T32-HL125294]
FX Catherine M. Bulka was supported by the National Heart, Lung, and Blood
   Institute (NHLBI) T32-HL125294.
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NR 56
TC 128
Z9 134
U1 1
U2 64
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0013-9351
EI 1096-0953
J9 ENVIRON RES
JI Environ. Res.
PD JAN
PY 2019
VL 168
BP 397
EP 405
DI 10.1016/j.envres.2018.10.022
PG 9
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA HE0ED
UT WOS:000452938700042
PM 30388496
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Zhang, X
   Lerman, LO
AF Zhang, Xin
   Lerman, Lilach O.
TI The metabolic syndrome and chronic kidney disease
SO TRANSLATIONAL RESEARCH
LA English
DT Review
ID OBESITY-RELATED GLOMERULOPATHY; MESANGIAL CELL HYPERTROPHY;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; MITOCHONDRIAL DYSFUNCTION; NAD(P)H
   OXIDASE; INTRAABDOMINAL PRESSURE; INDUCED HYPERTENSION;
   THERAPEUTIC-TARGET; RESPIRATORY-CHAIN
AB The metabolic syndrome (MetS) is a cluster of cardiovascular risk factors including insulin resistance (IR), dyslipidemia, and hypertension, which may also foster development of chronic kidney disease. The mechanisms of MetS-induced kidney disease are not fully understood. The purpose of this review is to summarize recent discoveries regarding the impact of MetS on the kidney, particularly on the renal microvasculature and cellular mitochondria. Fundamental manifestations of MetS include IR and adipose tissue expansion, the latter promoting chronic inflammation and oxidative stress that exacerbate IR. Those in turn can elicit various kidney injurious events through endothelial dysfunction, activation of the renin-angiotensin-aldosterone system, and adipokine imbalance. Inflammation and IR are also major contributors to microvascular remodeling and podocyte injury. Hence, these events may result in hypertension, albuminuria, and parenchymal damage. In addition, dyslipidemia and excessive nutrient availability may impair mitochondrial function and thereby promote progression of kidney cell damage. Elucidation of the link between MetS and kidney injury may help develop preventative measures and possibly novel therapeutic targets to alleviate and avert development of renal manifestations.
C1 [Zhang, Xin; Lerman, Lilach O.] Mayo Clin, Div Nephrol & Hypertens, 200 First St SW, Rochester, MN 55905 USA.
C3 Mayo Clinic
RP Lerman, LO (corresponding author), Mayo Clin, Div Nephrol & Hypertens, 200 First St SW, Rochester, MN 55905 USA.
EM lerman.lilach@mayo.edu
RI Lerman, Lilach/M-4962-2017
FU NIH [DK104273, DK102325, DK73608, DK100081, HL123160]
FX This work was partly supported by NIH Grants DK104273, DK102325,
   DK73608, DK100081, and HL123160.
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NR 144
TC 102
Z9 108
U1 0
U2 22
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1931-5244
EI 1878-1810
J9 TRANSL RES
JI Transl. Res.
PD MAY
PY 2017
VL 183
BP 14
EP 25
DI 10.1016/j.trsl.2016.12.004
PG 12
WC Medical Laboratory Technology; Medicine, General & Internal; Medicine,
   Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology; General & Internal Medicine; Research &
   Experimental Medicine
GA EU3TL
UT WOS:000400953800002
PM 28025032
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Iplikci, B
   Can, B
   Iplikci, A
   Sargin, M
AF Iplikci, Busra
   Can, Bulent
   Iplikci, Ayberk
   Sargin, Mehmet
TI How Does Metabolic Syndrome Affect Sexual Function in Obese Women?
SO KONURALP TIP DERGISI
LA English
DT Article
DE Bioelectrical Impedance; Female Sexual Dysfunction; Metabolic Syndrome;
   Obesity
ID INDEX FSFI; DYSFUNCTION; PREVALENCE
AB Objective: Metabolic syndrome (MetS) is significant public health concern with a rising prevalence. MetS leads to diseases such as diabetes mellitus, arterial hypertension (HTN) and atherosclerotic heart disease, as well as female sexual dysfunction (FSD). However, the relationship of MetS to female sexual function in obese woman is unclear. In our study, obese women and obese women with MetS were compared. We aimed to determine whether there was a difference between the two groups in terms of FSD. Method: The study included 114 patients, aged 21-51, who visited the obesity outpatient clinic of our center from January to April 2022. Patients who met the study criteria answered the sociodemographic data questionnaire, Female Sexual Function Index (FSFI), and the Beck Depression Inventory (BDI). Anthropometric measurements and blood pressure assessments were conducted during the visit, and blood tests were recorded. Results: Seventy-three (64%) patients were only obese, and 41 (36%) had a diagnosis of MetS with obesity. There was no significant difference between the two groups in terms of demographic data, clinical features, BDI scores, and FSFI total score. Lubrication, one of the FSFI subparameters, was found to be low in the group with MetS (p=0.028), while there was no difference in other subparameters. Conclusion: In this study, we showed that lubrication as a sign of arousal problem is affected by MetS. Patients with risk factors for FSD such as MetS, obesity, HTN, diabetes mellitus should not be ignored. Thus, it will be possible to prevent the effects of FSD on general health.
C1 [Iplikci, Busra; Sargin, Mehmet] Istanbul Medeniyet Univ, Fac Med, Dept Family Med, Istanbul, Turkiye.
   [Can, Bulent] Istanbul Medeniyet Univ, Fac Med, Dept Endocrinol, Istanbul, Turkiye.
   [Iplikci, Ayberk] Istanbul Medeniyet Univ, Fac Med, Dept Urol, Istanbul, Turkiye.
C3 Istanbul Medeniyet University; Istanbul Medeniyet University; Istanbul
   Medeniyet University
RP Iplikci, A (corresponding author), Istanbul Medeniyet Univ, Fac Med, Dept Urol, Istanbul, Turkiye.
EM ayberkiplikci@gmail.com
RI Iplikci, Ayberk/GPX-8439-2022; Can, Bülent/JCE-0561-2023; SARGIN,
   Mehmet/GLT-5402-2022
OI Iplikci, Ayberk/0000-0002-5822-7799
CR Adolfsson B, 2004, OBES RES, V12, P1702, DOI 10.1038/oby.2004.211
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   [Anonymous], 2016, Obesity and overweight fact sheet
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NR 26
TC 0
Z9 0
U1 0
U2 0
PU DUZCE UNIV, FAC MEDICINE
PI DUZCE
PA KONURALP CAMPUS YORUK MAH CENTER, DUZCE, 81620, Turkiye
SN 1309-3878
J9 KONURALP TIP DERG
JI Konuralp Tip Derg.
PY 2024
VL 16
IS 3
BP 311
EP 316
DI 10.18521/ktd.1524374
PG 6
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA N3C8Y
UT WOS:001363168300002
OA gold
DA 2025-06-11
ER

PT J
AU Fikry, H
   Saleh, LA
   Sadek, DR
   Alkhalek, HAA
AF Fikry, Heba
   Saleh, Lobna A.
   Sadek, Doaa Ramadan
   Alkhalek, Hadwa Ali Abd
TI The possible protective effect of luteolin on cardiovascular and hepatic
   changes in metabolic syndrome rat model
SO CELL AND TISSUE RESEARCH
LA English
DT Article
DE Metabolic syndrome; Fructose; Liver; Heart; Rats; Histological
ID FATTY LIVER-DISEASE; INSULIN-RESISTANCE; HIGH-FRUCTOSE; DIETARY
   FRUCTOSE; OXIDATIVE STRESS; ADIPOSE-TISSUE; STELLATE CELLS; TNF-ALPHA;
   KAPPA-B; FIBROSIS
AB The metabolic syndrome, or MetS, is currently a global health concern. The anti-inflammatory, anti-proliferative, and antioxidant properties of luteolin are some of its advantageous pharmacological characteristics. This research was designed to establish a MetS rat model and investigate the possible protective effect of luteolin on cardiovascular, hepatic, and metabolic changes in diet-induced metabolic syndrome in rats. Forty adult male albino rats were split into four groups: a negative control group, a group treated with luteolin, a group induced MetS (fed 20% fructose), and a group treated with luteolin (fed 20% fructose and given luteolin). Following the experiment after 8 weeks, biochemical, histological (light and electron), and immunohistochemistry analyses were performed on liver and heart tissues. Serum levels of cTnI, CK-MB, and LDH were significantly elevated in response to the cardiovascular effect of MetS. Furthermore, compared to the negative control group, the MetS group showed a marked increase in lipid peroxidation in the cardiac and hepatic tissues, as evidenced by elevated levels of MDA and a decline in the antioxidant defense system, as demonstrated by lower activities of GSH and SOD. The fatty liver-induced group exhibited histological alterations, including disrupted hepatic architecture, dilated and congested central veins, blood sinusoids, and portal veins. In addition to nuclear structural alterations, most hepatocytes displayed varying degrees of cytoplasmic vacuolation, mitochondrial alterations, and endoplasmic reticulum dilatation. These alterations were linked to inflammatory cellular infiltrations, collagen fiber deposition, active hepatic stellate cells, and scattered hypertrophied Kupffer cells, as demonstrated by electron microscopy and validated by immunohistochemical analysis. It is interesting to note that eosinophils were seen between the liver cells and in dilated blood sinusoids. Moreover, the biochemical (hepatic and cardiac) and histological (liver) changes were significantly less severe in luteolin-treated rat on a high-fructose diet. These results suggested that luteolin protects against a type of metabolic syndrome that is produced experimentally.
C1 [Fikry, Heba; Sadek, Doaa Ramadan; Alkhalek, Hadwa Ali Abd] Ain Shams Univ, Fac Med, Dept Histol & Cell Biol, Khalifa El Maamon St,Abbasiya Sq, Cairo, Egypt.
   [Saleh, Lobna A.] Ain Shams Univ, Fac Med, Dept Clin Pharmacol, Khalifa El Maamon St,Abbasiya Sq, Cairo, Egypt.
C3 Egyptian Knowledge Bank (EKB); Ain Shams University; Egyptian Knowledge
   Bank (EKB); Ain Shams University
RP Fikry, H (corresponding author), Ain Shams Univ, Fac Med, Dept Histol & Cell Biol, Khalifa El Maamon St,Abbasiya Sq, Cairo, Egypt.
EM hebafikry@med.asu.edu.eg; Lobnasaleh_80@yahoo.com;
   d.sadek@med.asu.edu.eg; Hadwa.ali@gmail.com
RI fikry, heba/GRN-8415-2022
OI fikry, heba/0000-0002-0046-9875
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NR 140
TC 2
Z9 2
U1 5
U2 5
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0302-766X
EI 1432-0878
J9 CELL TISSUE RES
JI Cell Tissue Res.
PD JAN
PY 2025
VL 399
IS 1
BP 27
EP 60
DI 10.1007/s00441-024-03927-1
EA NOV 2024
PG 34
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA S6U3E
UT WOS:001350179900001
PM 39514020
DA 2025-06-11
ER

PT J
AU Soeiro-de-Souza, MG
   Gold, PW
   Brunoni, AR
   de Sousa, RT
   Zanetti, MV
   Carvalho, AF
   Gattaz, WF
   Machado-Vieira, R
   Teixeira, AL
AF Soeiro-de-Souza, Marcio Gerhardt
   Gold, Philip W.
   Brunoni, Andre R.
   de Sousa, Rafael T.
   Zanetti, Marcus V.
   Carvalho, Andre F.
   Gattaz, Wagner Farid
   Machado-Vieira, Rodrigo
   Teixeira, Antonio Lucio
TI Lithium Decreases Plasma Adiponectin Levels in Bipolar Depression
SO NEUROSCIENCE LETTERS
LA English
DT Article
DE Lithium; Adiponectin; Bipolar; Disorder; Depression; Metabolic;
   Treatment
ID MOOD DISORDERS; LEPTIN; OBESITY; RESISTIN; INFLAMMATION; ADIPOKINES
AB Lithium, a first line treatment for bipolar disorder (BD), has been associated with significant weight gain, but the mechanisms underlying this phenomenon are still unclear. It has been suggested that changes in production/release of adipokines - molecules secreted by adipose tissue presenting anti-inflammatory (adiponectin) and pro-inflammatory (leptin, resistin) properties - might be implicated. Adiponectin, resistin and leptin were assessed in 25 acutely depressed BD individuals (88% medication-free and 68% treatment-naive) at baseline and after 6 weeks of lithium therapy, and in 23 healthy controls matched by age. The 21-item Hamilton Depression Rating Scale was used to assess depression severity. Levels of adiponectin significantly decreased after lithium monotherapy, while the levels of resistin and leptin remained stable after the follow-up period. Adipokine levels during depressive episodes in BD did not differ compared to controls. Pretreatment levels of leptin were higher in remitters and changes in resistin levels were negatively correlated to improvement of depressive symptoms with lithium. Our findings shed light in this pathophysiological process, which might be associated with metabolic syndrome, inflammation and other medical comorbidities in BD. Published by Elsevier Ireland Ltd.
C1 [Soeiro-de-Souza, Marcio Gerhardt] Univ Sao Paulo, Dept & Inst Psychiat, Mood Disorders Unit GRUDA, BR-05508 Sao Paulo, Brazil.
   [Gold, Philip W.; Machado-Vieira, Rodrigo] NIMH, NIH, Bethesda, MD 20892 USA.
   [Brunoni, Andre R.] Univ Sao Paulo, Serv Interdisciplinary Neuromodulat, Interdisciplinary Ctr Appl Neuromodulat, Dept & Inst Psychiat,Univ Hosp, Ribeirao Preto, Brazil.
   [de Sousa, Rafael T.; Zanetti, Marcus V.; Gattaz, Wagner Farid; Machado-Vieira, Rodrigo] Univ Sao Paulo, Dept & Inst Psychiat, Lab Neurosci, BR-05508 Sao Paulo, Brazil.
   [Zanetti, Marcus V.; Gattaz, Wagner Farid; Machado-Vieira, Rodrigo] Univ Sao Paulo, Ctr Interdisciplinary Res Appl Neurosci NAPNA, Ribeirao Preto, Brazil.
   [Carvalho, Andre F.] Univ Fed Ceara, Fac Med, Psychiat Res Grp, Fortaleza, Ceara, Brazil.
   [Teixeira, Antonio Lucio] Univ Minas Gerais UFMG, Div Neurol, Neuropsychiat Branch, Belo Horizonte, MG, Brazil.
C3 National Institutes of Health (NIH) - USA; NIH National Institute of
   Mental Health (NIMH); Universidade de Sao Paulo; Universidade Federal do
   Ceara
RP Machado-Vieira, R (corresponding author), Sch Med, Inst & Dept Psychiat, Rua Ovidio Pires de Campos 785, BR-01060970 Sao Paulo, Brazil.
EM marciogss@gmail.com; machadovieirar@gmail.com
RI Gattaz, Wagner/C-4456-2012; Carvalho, Andre/AEZ-4001-2022; Zanetti,
   Marcus/A-9013-2008; Teixeira, Antonio/N-3315-2014; Soeiro-de-Souza,
   M./J-9430-2012; MACHADO-VIEIRA, RODRIGO/D-8293-2012; Russowsky Brunoni,
   Andre/H-8394-2012
OI Teixeira, Antonio Lucio/0000-0002-9621-5422; Gerhardt Soeiro-de-Souza,
   Marcio/0000-0002-9293-3128; MACHADO-VIEIRA, RODRIGO/0000-0002-4830-1190;
   Russowsky Brunoni, Andre/0000-0002-6310-3571
FU Sao Paulo Research Foundation (FAPESP, Brazil) [2009/14891-9]; CNPq;
   Fapemig; Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
   [09/14891-9] Funding Source: FAPESP
FX This study was sponsored by Sao Paulo Research Foundation (FAPESP,
   Brazil) (2009/14891-9), CNPq, and Fapemig.
CR Ahima RS, 2006, OBESITY, V14, p9S, DOI 10.1038/oby.2006.276
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NR 31
TC 32
Z9 32
U1 0
U2 8
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0304-3940
EI 1872-7972
J9 NEUROSCI LETT
JI Neurosci. Lett.
PD APR 3
PY 2014
VL 564
BP 111
EP 114
DI 10.1016/j.neulet.2014.02.005
PG 4
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA AF8SK
UT WOS:000334985700022
PM 24525248
DA 2025-06-11
ER

PT J
AU Jackson, SE
   Steptoe, A
AF Jackson, Sarah E.
   Steptoe, Andrew
TI Obesity, perceived weight discrimination, and hair cortisol: a
   population-based study
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE Obesity; Weight-related discrimination; Stigma; Stress; Cortisol
ID METABOLIC SYNDROME; SCALP HAIR; STRESS; STIGMA; BIAS; ASSOCIATIONS;
   PREVALENCE; PREDICTORS; REDUCTION; MEDIATION
AB Background and purpose: Stigmatization of individuals with obesity is pervasive and may act as a psychological stressor. The present study examined whether perceived weight discrimination mediated the relationship between obesity and cortisol, an objective marker of chronic stress, in a population-based sample.
   Methods: Data were from the English Longitudinal Study of Ageing (n = 1872). Height and weight were objectively measured in 2008/09. Experiences of weight-related discrimination were reported via questionnaire in 2010/11. Hair cortisol concentrations were determined from the scalp-nearest 2 cm hair segment in 2012/13. Mediation analyses tested the role of perceived weight discrimination in the associations between obesity and BMI and hair cortisol concentration, adjusting for age, sex, ethnicity, socio-economic status, smoking status, depression and hair-related factors.
   Results: Obesity, BMI and perceived weight discrimination were positively related to hair cortisol (all p < .01). Perceived weight discrimination significantly mediated associations between obesity and hair cortisol (beta = 0.021, SE = 0.007, 95% CI 0.007-0.036) and BMI and hair cortisol (beta = 0.001, SE = 0.0004, 95% CI 0.0004-0.002), accounting for 19% of the total effect of obesity and 23% of the total effect of BMI on hair cortisol.
   Conclusions: Perceived weight discrimination is an important mediator of the association between obesity and cortisol. Interventions combating weight stigma and discrimination or promoting strategies for coping with stress could help to lessen the psychological and physiological burden of obesity.
C1 [Jackson, Sarah E.; Steptoe, Andrew] UCL, Dept Behav Sci & Hlth, 1-19 Torrington Pl, London WC1E 6BT, England.
C3 University of London; University College London
RP Jackson, SE (corresponding author), UCL, Dept Behav Sci & Hlth, 1-19 Torrington Pl, London WC1E 6BT, England.
EM s.e.jackson@ucl.ac.uk
RI Steptoe, Andrew/Y-2440-2019; Jackson, Sarah/J-9046-2019
OI Jackson, Sarah/0000-0001-5658-6168
FU Cancer Research UK [C1418/A14133]
FX This work was supported by a grant from Cancer Research UK
   (C1418/A14133).
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NR 58
TC 33
Z9 38
U1 2
U2 26
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD DEC
PY 2018
VL 98
BP 67
EP 73
DI 10.1016/j.psyneuen.2018.08.018
PG 7
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA HA6HR
UT WOS:000450381100010
PM 30118922
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Lehman, BJ
   Taylor, SE
   Kiefe, CI
   Seeman, TE
AF Lehman, BJ
   Taylor, SE
   Kiefe, CI
   Seeman, TE
TI Relation of childhood socioeconomic status and family environment to
   adult metabolic functioning in the CARDIA study
SO PSYCHOSOMATIC MEDICINE
LA English
DT Article
DE stress; family; health; SES; comorbidities; HPA
ID 3RD NATIONAL-HEALTH; NEGATIVE EMOTIONS; PHYSICAL HEALTH; SOCIAL TIES;
   HOSTILITY; STRESS; MEN; CONSEQUENCES; ASSOCIATION; MEDIATORS
AB Objective: Low SES and a conflict-ridden, neglectful, or harsh family environment in childhood have been linked to a high rate of physical health disorders in adulthood. The objective of the present investigation was to evaluate a model of the pathways that may help to explain these links and to relate them to metabolic functioning (MF) in the Coronary Artery Risk Development In Young Adults (CARDIA) dataset. Methods: Participants (n = 3225) in the year 15 assessment of CARDIA, age 33 to 45 years, completed measures of childhood socioeconomic status (SES), risky early family environment (RF), adult psychosocial functioning (PsyF, a latent factor measured by depression, hostility, positive and negative social contacts), and adult SES. Indicators of the latent factor MF were assessed, specifically, cholesterol, insulin, glucose, triglycerides, and waist circumference. Results: The overall prevalence of metabolic syndrome was 9.7%. Structural equation modeling indicated that childhood SES and RF are associated with MF via their association with PsyF (standardized path coefficients: childhood SES to RF -0.13, RF to PsyF 0.44, PsyF to MF 0.09, all p < .05), but also directly (coefficient from childhood SES to MF -0.12,p < .05), with good overall model fit. When this model was tested separately for race-sex subgroups, it fit best for white women, fit well for African-American women and white men, but did not fit well for African-American men. Conclusions: These results indicate that childhood SES and early family environment contribute to metabolic functioning through pathways of depression, hostility, and poor quality of social contacts.
C1 Univ Calif Los Angeles, Dept Psychol, Los Angeles, CA 90095 USA.
   Univ Calif Los Angeles, Dept Geriatr, Los Angeles, CA 90095 USA.
   Univ Alabama Birmingham, Div Prevent Med, Birmingham, AL USA.
   Vet Affairs Med Ctr, Birmingham, AL USA.
   Western Washington Univ, Dept Psychol, Bellingham, WA 98225 USA.
C3 University of California System; University of California Los Angeles;
   University of California System; University of California Los Angeles;
   University of Alabama System; University of Alabama Birmingham; US
   Department of Veterans Affairs; Veterans Health Administration (VHA);
   Western Washington University
RP Univ Calif Los Angeles, Dept Psychol, 1282A Franz Hall, Los Angeles, CA 90095 USA.
EM taylors@psych.ucla.edu
RI Lehman, Barbara/H-4798-2019
OI Lehman, Barbara/0000-0002-2887-3466
FU National Institute of Mental Health [T32MH015750] Funding Source: NIH
   RePORTER; NHLBI NIH HHS [N01-HC-48050, N01-HC-95095, N01-HC-45134,
   N01-HC-48049, N01-HC-48048, N01-HC-05187, N01-HC-48047] Funding Source:
   Medline; NIMH NIH HHS [MH15750] Funding Source: Medline
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NR 49
TC 142
Z9 163
U1 0
U2 19
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0033-3174
EI 1534-7796
J9 PSYCHOSOM MED
JI Psychosom. Med.
PD NOV-DEC
PY 2005
VL 67
IS 6
BP 846
EP 854
DI 10.1097/01.psy.0000188443.48405.eb
PG 9
WC Psychiatry; Psychology; Psychology, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry; Psychology
GA 989QZ
UT WOS:000233690100004
PM 16314588
DA 2025-06-11
ER

PT J
AU Ehrlich, KB
AF Ehrlich, Katherine B.
TI How Does the Social World Shape Health Across the Lifespan? Insights and
   New Directions
SO AMERICAN PSYCHOLOGIST
LA English
DT Article
DE social determinants of health; stress; health disparities; inflammation;
   chronic disease
ID ADVERSE CHILDHOOD EXPERIENCES; ANTIBODY-RESPONSE; INFLUENZA VACCINATION;
   SOCIOECONOMIC-STATUS; METABOLIC SYNDROME; IMMUNE-RESPONSE;
   SEX-DIFFERENCES; YOUNG; INFLAMMATION; DEPRESSION
AB Decades of research highlight the connections between stressful life experiences-particularly those experienced in childhood-and physical health across the lifespan. In recent years, studies at the intersection of social and biomedical science have provided intriguing insights into the biological mechanisms that might explain how chronic and acute stressors give rise to health problems, sometimes decades later in life. To date, efforts to understand these connections have relied on a handful of study designs, and these studies have revealed important observations about how stressful experiences are thought to shape health. At the same time, these study designs have some drawbacks that limit the conclusions that can be drawn about the role of the social world for health. This article provides an overview of research on social determinants of health and includes a discussion of conceptual and methodological directions for the field to consider.
C1 [Ehrlich, Katherine B.] Univ Georgia, Dept Psychol, 125 Baldwin St, Athens, GA 30602 USA.
   [Ehrlich, Katherine B.] Univ Georgia, Ctr Family Res, Athens, GA 30602 USA.
C3 University System of Georgia; University of Georgia; University System
   of Georgia; University of Georgia
RP Ehrlich, KB (corresponding author), Univ Georgia, Dept Psychol, 125 Baldwin St, Athens, GA 30602 USA.
EM kehrlich@uga.edu
OI Ehrlich, Katherine/0000-0002-8958-6161
FU NIH Common Fund [DP2 MD013947]; Jacobs Foundation (Early Career Research
   Fellowship) [2018-1288-07]; Brain and Behavior Research Foundation
   [27302]
FX I am grateful to Kelsey L. Corallo and Sarah M. Lyle for their helpful
   comments on a draft of this article. Preparation of this article was
   supported by the NIH Common Fund (DP2 MD013947), the Jacobs Foundation
   (Early Career Research Fellowship, 2018-1288-07), and the Brain and
   Behavior Research Foundation (Young Investigator Grant 27302).
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NR 76
TC 5
Z9 5
U1 1
U2 5
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 0003-066X
EI 1935-990X
J9 AM PSYCHOL
JI Am. Psychol.
PD DEC
PY 2020
VL 75
IS 9
BP 1231
EP 1241
DI 10.1037/amp0000757
PG 11
WC Psychology, Multidisciplinary
WE Social Science Citation Index (SSCI)
SC Psychology
GA PO1FB
UT WOS:000604915200010
PM 33382288
OA hybrid, Green Accepted
DA 2025-06-11
ER

PT J
AU Viscogliosi, G
   Donfrancesco, C
   Palmieri, L
   Giampaoli, S
AF Viscogliosi, Giovanni
   Donfrancesco, Chiara
   Palmieri, Luigi
   Giampaoli, Simona
TI The metabolic syndrome and 10-year cognitive and functional decline in
   very old men. A population-based study
SO ARCHIVES OF GERONTOLOGY AND GERIATRICS
LA English
DT Article
DE Metabolic syndrome; Cognitive decline; Functional disability; Incidence
ID ASSOCIATION; HEALTH; RISK; DEPRESSION; IMPAIRMENT; DISABILITY; FRAILTY;
   LIFE; AGE
AB Objectives: To describe longitudinal relationships of metabolic syndrome (MetS) to cognitive decline and functional disability in a sample of older non-institutionalized men.
   Methods: data from 1991 to 2000 of the Italian cohorts of the Finland, Italy, the Netherlands, Elderly (FINE) study, were used. Global cognitive function and functional disability, defined as limitations in mobility, basic (ADLs) and instrumental activities of daily living (IADLs) were screened in 1991 and 2000. MetS was defined according to the NCEP ATP-III criteria.
   Results: The study sample consisted of 195 men, baseline age 76.1 +/- 3.1 years. Baseline MetS was prospectively associated with greater 10-year cognitive and functional decline in ADLs and IADLs. After multiple adjustment including age, education, marital status, ApoE epsilon 4 allele, cerebrovascular disease and initial cognitive and depressive status, MetS predicted cognitive decline (B = - 1.684, 95% CI = - 2.202 to - 1.167, p < 0.001) and risk of IADLs (OR = 1.09, 95% CI = 1.01-1.20, p = 0.048) and ADLs disability (OR = 1.35, 95% CI = 1.12-1.62, p < 0.001). Interestingly, such associations were not attributable to individual altered components of MetS nor to their sum. Incident disability in ADLs and IADLs were not explained by parallel decline in cognitive function.
   Conclusions: MetS as an entity was associated with accelerated cognitive and functional decline in a population-based sample of very old men. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
C1 [Viscogliosi, Giovanni; Donfrancesco, Chiara; Palmieri, Luigi; Giampaoli, Simona] Natl Inst Hlth, Dept Epidemiol Surveillance & Promot Hlth, Rome, Italy.
   [Viscogliosi, Giovanni] Sapienza Univ, Dept Cardiovasc Resp Nephrol Anesthesiol & Geriat, Dept Gerontol, Rome, Italy.
C3 Istituto Superiore di Sanita (ISS); Sapienza University Rome
RP Viscogliosi, G (corresponding author), Sapienza Univ, Via Giano Della Bella 34, I-00162 Rome, Italy.
EM giovanni.viscogliosi@libero.it
RI donfrancesco, chiara/K-1460-2016; Palmieri, Luigi/O-1845-2017
OI donfrancesco, chiara/0000-0002-8040-5571; Palmieri,
   Luigi/0000-0002-4298-2642
FU CUORE Project - Epidemiology of Cardiovascular diseases - Italian
   National Institute of Health
FX The Italian section of the FINE study was supported by the CUORE Project
   - Epidemiology of Cardiovascular diseases, supported by the Italian
   National Institute of Health.
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NR 22
TC 19
Z9 20
U1 0
U2 7
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0167-4943
EI 1872-6976
J9 ARCH GERONTOL GERIAT
JI Arch. Gerontol. Geriatr.
PD MAY-JUN
PY 2017
VL 70
BP 62
EP 66
DI 10.1016/j.archger.2016.12.008
PG 5
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA ES4EF
UT WOS:000399481500009
PM 28076836
DA 2025-06-11
ER

PT J
AU Alemany, M
AF Alemany, Maria
TI Utilization of dietary glucose in the metabolic syndrome
SO NUTRITION & METABOLISM
LA English
DT Review
DE metabolic syndrome; insulin resistance; adipose tissue; hyperlipidemia;
   glycolysis; glucose fate
ID BROWN ADIPOSE-TISSUE; INDUCED INSULIN-RESISTANCE; FATTY LIVER-DISEASE;
   DENSITY-LIPOPROTEIN CHOLESTEROL; ENDOPLASMIC-RETICULUM STRESS; HUMAN
   SKELETAL-MUSCLE; DE-NOVO LIPOGENESIS; LACTATE PRODUCTION; FOOD-INTAKE;
   RAT-LIVER
AB This review is focused on the fate of dietary glucose under conditions of chronically high energy (largely fat) intake, evolving into the metabolic syndrome. We are adapted to carbohydrate-rich diets similar to those of our ancestors. Glucose is the main energy staple, but fats are our main energy reserves. Starvation drastically reduces glucose availability, forcing the body to shift to fatty acids as main energy substrate, sparing glucose and amino acids. We are not prepared for excess dietary energy, our main defenses being decreased food intake and increased energy expenditure, largely enhanced metabolic activity and thermogenesis. High lipid availability is a powerful factor decreasing glucose and amino acid oxidation. Present-day diets are often hyperenergetic, high on lipids, with abundant protein and limited amounts of starchy carbohydrates. Dietary lipids favor their metabolic processing, saving glucose, which additionally spares amino acids. The glucose excess elicits hyperinsulinemia, which may derive, in the end, into insulin resistance. The available systems of energy disposal could not cope with the excess of substrates, since they are geared for saving not for spendthrift, which results in an unbearable overload of the storage mechanisms. Adipose tissue is the last energy sink, it has to store the energy that cannot be used otherwise. However, adipose tissue growth also has limits, and the excess of energy induces inflammation, helped by the ineffective intervention of the immune system. However, even under this acute situation, the excess of glucose remains, favoring its final conversion to fat. The sum of inflammatory signals and deranged substrate handling induce most of the metabolic syndrome traits: insulin resistance, obesity, diabetes, liver steatosis, hyperlipidemia and their compounded combined effects. Thus, a maintained excess of energy in the diet may result in difficulties in the disposal of glucose, eliciting inflammation and the development of the metabolic syndrome
C1 [Alemany, Maria] Univ Barcelona, Fac Biol, Dept Nutr & Food Sci, Barcelona, Spain.
   [Alemany, Maria] Inst Hlth Carlos III, CIBER Obes & Nutr, Madrid, Spain.
C3 University of Barcelona; CIBER - Centro de Investigacion Biomedica en
   Red; CIBEROBN
RP Alemany, M (corresponding author), Univ Barcelona, Fac Biol, Dept Nutr & Food Sci, Barcelona, Spain.
EM malemany@ub.edu
RI Alemany, Maria/H-5224-2011
OI Alemany, Maria/0000-0002-9783-8293
FU Government of Spain [SAF2009-11739]
FX Supported by grant SAF2009-11739 of the Plan Nacional de Investigacion
   en Biomedicina of the Government of Spain.
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NR 197
TC 17
Z9 18
U1 0
U2 15
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1743-7075
J9 NUTR METAB
JI Nutr. Metab.
PD OCT 26
PY 2011
VL 8
AR 74
DI 10.1186/1743-7075-8-74
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 853DI
UT WOS:000297406000001
PM 22029632
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Tefagh, G
   Payab, M
   Qorbani, M
   Sharifi, F
   Sharifi, Y
   Shirvani, MSE
   Pourghazi, F
   Atlasi, R
   Shadman, Z
   Rezaei, N
   Mohammadi-Vajari, E
   Larijani, B
   Ebrahimpur, M
AF Tefagh, Ghazale
   Payab, Moloud
   Qorbani, Mostafa
   Sharifi, Farshad
   Sharifi, Yasaman
   Shirvani, Mahbubeh Sadat Ebrahimnegad
   Pourghazi, Farzad
   Atlasi, Rasha
   Shadman, Zhaleh
   Rezaei, Nafiseh
   Mohammadi-Vajari, Erfan
   Larijani, Bagher
   Ebrahimpur, Mahbube
TI Effect of vitamin E supplementation on cardiometabolic risk factors,
   inflammatory and oxidative markers and hormonal functions in PCOS
   (polycystic ovary syndrome): a systematic review and meta-analysis
SO SCIENTIFIC REPORTS
LA English
DT Article
ID E CO-SUPPLEMENTATION; INSULIN-RESISTANCE; GENE-EXPRESSION;
   OMEGA-3-FATTY-ACIDS; PATHOPHYSIOLOGY; DYSLIPIDEMIA; PARAMETERS; OMEGA-3;
   STRESS; LIPIDS
AB Polycystic ovary syndrome (PCOS) is a common endocrinopathy among reproductive-age women. Various therapeutical approaches are currently used to manage or control symptoms associated with PCOS. This systematic review intended to assess the effects of Vit E supplementation on cardiometabolic risk factors, inflammatory and oxidative markers, and hormonal functions in PCOS women based on the clinical trial's results. The databases including PubMed, Scopus, Cochrane, Web of Science, and Embase were used to find all relevant studies. The authors reviewed all relevant clinical trials via systematic evaluation of abstracts and titles. Searches were conducted on August 1, 2020. After the initial search and reading of the article's title and abstract, 353 articles were reviewed; finally, 12 articles met the inclusion criteria. Vitamin E supplementation improves lipid profile, decreases insulin and HOMA-IR levels. Furthermore, while Vitamin E supplementation decreases LH and testosterone concentrations, it increases FSH and progestrone concentrations. The following meta-analysis showed that vitamin E supplementation made statistically significant improvements in triglyceride (TG) and low-density lipoproteins (LDL) levels, meanwhile, pooled mean difference for waist circumference (WC) and HOMA-IR were also statistically significant. Supplementary regimens containing vitamin E can positively affect metabolic and hormonal parameters in women with PCOS.
C1 [Tefagh, Ghazale] Univ Tehran Med Sci, Adv Diagnost & Intervent Radiol Res Ctr, Imam Khomeini Hosp Complex, Tehran, Iran.
   [Payab, Moloud; Sharifi, Yasaman; Pourghazi, Farzad; Larijani, Bagher] Univ Tehran Med Sci, Endocrinol & Metab Res Ctr, Endocrinol & Metab Clin Sci Inst, First Floor,10 Jalal Al Ahmad St,North Kargar Ave, Tehran 1411713137, Iran.
   [Qorbani, Mostafa] Alborz Univ Med Sci, Noncommunicable Dis Res Ctr, Karaj, Iran.
   [Sharifi, Farshad; Shadman, Zhaleh; Ebrahimpur, Mahbube] Univ Tehran Med Sci, Elderly Hlth Res Ctr, Endocrinol & Metab Populat Sci Inst, First Floor,10 Jalal Al Ahmad St,North Kargar Ave, Tehran 1411713137, Iran.
   [Shirvani, Mahbubeh Sadat Ebrahimnegad] Iran Univ Med Sci, Sch Med, Dept Emergency Med, Tehran, Iran.
   [Atlasi, Rasha] Univ Tehran Med Sci, Evidence Based Practice Res Ctr, Endocrinol & Metab Res Inst, Tehran, Iran.
   [Rezaei, Nafiseh] Univ Tehran Med Sci, Paramed Fac, Dept Med Lib & Informat Sci, Tehran, Iran.
   [Rezaei, Nafiseh] Hamadan Univ Med Sci, Paramed Fac, Dept Med Lib & Informat Sci, Hamadan, Hamadan, Iran.
   [Mohammadi-Vajari, Erfan] Guilan Univ Med Sci, Sch Med, Rasht, Iran.
C3 Tehran University of Medical Sciences; Tehran University of Medical
   Sciences; Alborz University of Medical Sciences; Tehran University of
   Medical Sciences; Iran University of Medical Sciences; Tehran University
   of Medical Sciences; Tehran University of Medical Sciences; Hamadan
   University of Medical Sciences; Guilan University of Medical Sciences
RP Payab, M (corresponding author), Univ Tehran Med Sci, Endocrinol & Metab Res Ctr, Endocrinol & Metab Clin Sci Inst, First Floor,10 Jalal Al Ahmad St,North Kargar Ave, Tehran 1411713137, Iran.; Ebrahimpur, M (corresponding author), Univ Tehran Med Sci, Elderly Hlth Res Ctr, Endocrinol & Metab Populat Sci Inst, First Floor,10 Jalal Al Ahmad St,North Kargar Ave, Tehran 1411713137, Iran.
EM moloudpayab@gmail.com; m-ebrahimpur@tums.ac.ir
RI Pourghazi, Farzad/KYD-7103-2024; Qorbani, Mostafa/M-8171-2017; Sharifi,
   Yasaman/AAU-5007-2021; Atlasi, Rasha/HKW-2346-2023; Rezaei,
   Nafiseh/JDM-8067-2023; Mohammadi-Vajari, Erfan/AAW-6515-2021; larijani,
   Bagher/ABE-3315-2020
OI Mohammadi-Vajari, Erfan/0000-0002-9849-3485; Pourghazi,
   Farzad/0000-0002-9684-1466; Larijani, Bagher/0000-0001-5386-7597;
   Rezaei, Nafiseh/0000-0002-5763-4974; Sharifi,
   Yasaman/0000-0001-5563-6311; Tefagh, Ghazale/0000-0002-1119-6438
FU Tehran University of Medical Sciences (Endocrinology and Metabolism
   Research Center)
FX Implementation of this study was sponsored by the Tehran University of
   Medical Sciences (Endocrinology and Metabolism Research Center).
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NR 32
TC 20
Z9 20
U1 0
U2 9
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD APR 6
PY 2022
VL 12
IS 1
AR 5770
DI 10.1038/s41598-022-09082-3
PG 16
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 0J5SN
UT WOS:000780164200015
PM 35388031
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Oluwagbemigun, K
   Anesi, A
   Ulaszewska, M
   Clarke, G
   Alexy, U
   Schmid, M
   Roden, M
   Herder, C
   Mattivi, F
   Nöthlings, U
AF Oluwagbemigun, Kolade
   Anesi, Andrea
   Ulaszewska, Maria
   Clarke, Gerard
   Alexy, Ute
   Schmid, Matthias
   Roden, Michael
   Herder, Christian
   Mattivi, Fulvio
   Noethlings, Ute
TI Longitudinal relationship of amino acids and indole metabolites with
   long-term body mass index and cardiometabolic risk markers in young
   individuals
SO SCIENTIFIC REPORTS
LA English
DT Article
ID INSULIN-RESISTANCE; BRANCHED-CHAIN; HUMAN GUT; METABOLOMIC PROFILES;
   KYNURENINE PATHWAY; CHILDHOOD OBESITY; OXIDATIVE STRESS; TRYPTOPHAN;
   BIOMARKERS; PLASMA
AB Amino acid metabolites in biofluids are associated with high body mass index (BMI) and cardiometabolic abnormalities. However, prospective investigations regarding these associations are few, particularly among young individuals. Moreover, little is presently known about the impact of long-term high BMI. Using data from the DOrtmund Nutritional and Anthropometric Longitudinally Designed study (111 males and 107 females), we prospectively investigated relations between repeatedly measured urinary levels of 33 metabolites and (1) previously identified long-term BMI trajectory groups from childhood into late adolescence and (2) cardiometabolic risk markers in late adolescence-young adulthood, in sex-specific linear mixed regression models. Males with long-term overweight had lower indole-3-acetic acid when compared to others. Further, methionine, isoleucine, tryptophan, xanthurenic acid, and indole-3-carboxaldehyde were negatively associated with C-reactive protein (CRP), but 5-hydroxyindole-3-acetic acid was positively associated with CRP. No associations were observed in females. Long-term overweight from childhood into late adolescence is associated with decreased urinary levels of gut bacteria-derived indole-3-acetic acid, and several urinary amino acids, including gut bacteria-derived indole-3-carboxaldehyde are associated with elevated CRP later on in life. Taken together, our data suggest that indole metabolites, and their gut bacteria producers play potentially important roles in overweight-related inflammation.
C1 [Oluwagbemigun, Kolade; Alexy, Ute; Noethlings, Ute] Univ Bonn, Dept Nutr & Food Sci, Nutr Epidemiol, Bonn, Germany.
   [Anesi, Andrea; Ulaszewska, Maria; Mattivi, Fulvio] Fdn Edmund Mach FEM, Dept Food Qual & Nutr, Res & Innovat Ctr, San Michele All Adige, Italy.
   [Clarke, Gerard] Univ Coll Cork, APC Microbiome Ireland, Cork, Ireland.
   [Clarke, Gerard] Univ Coll Cork, INFANT Res Ctr, Cork, Ireland.
   [Clarke, Gerard] Univ Coll Cork, Dept Psychiat & Neurobehav Sci, Cork, Ireland.
   [Schmid, Matthias] Univ Bonn, Univ Hosp Bonn, Dept Med Biometry Informat & Epidemiol, Bonn, Germany.
   [Roden, Michael; Herder, Christian] Heinrich Heine Univ Dusseldorf, Fac Med, Div Endocrinol & Diabetol, Dusseldorf, Germany.
   [Herder, Christian] Heinrich Heine Univ Dusseldorf, Leibniz Ctr Diabet Res, German Diabet Ctr, Inst Clin Diabetol, Dusseldorf, Germany.
   [Herder, Christian] German Ctr Diabet Res DZD, Munich, Germany.
   [Mattivi, Fulvio] Univ Trento, Dept Phys, San Michele All Adige, Italy.
C3 University of Bonn; Fondazione Edmund Mach; University College Cork;
   University College Cork; University College Cork; University of Bonn;
   Heinrich Heine University Dusseldorf; Heinrich Heine University
   Dusseldorf; Leibniz Association; Deutsches Diabetes-Zentrum (DDZ);
   German Center for Diabetes Research (DZD); University of Trento
RP Oluwagbemigun, K (corresponding author), Univ Bonn, Dept Nutr & Food Sci, Nutr Epidemiol, Bonn, Germany.
EM koluwagb@uni-bonn.de
RI Nöthlings, Ute/B-2713-2010; Roden, Michael/AAD-3843-2019; Oluwagbemigun,
   Kolade/AAV-2041-2021; Ulaszewska, Maria/AAI-2595-2019; Anesi,
   Andrea/ACJ-6729-2022; Alexy, Ute/E-8589-2018; Clarke,
   Gerard/Y-2551-2019; MATTIVI, FULVIO/B-7645-2011
OI MATTIVI, FULVIO/0000-0003-4935-5876; Ulaszewska,
   Maria/0000-0002-0929-2359; Anesi, Andrea/0000-0002-9334-2610;
   Oluwagbemigun, Kolade/0000-0002-9454-5970; Alexy,
   Ute/0000-0002-1488-5175; Nothlings, Ute/0000-0002-5789-2252; Schmid,
   Matthias/0000-0002-0788-0317; Clarke, Gerard/0000-0001-9771-3979
FU project "Metabolic HEALTH through nutrition, microbiota and tryptophan
   bioMARKers" of the EU Joint Programming Initiative "A Healthy Diet for a
   Healthy Life" (ERA HDHL -HEALTHMARK); Federal Ministry of Education and
   Research (BMBF), Germany [01EA1705A]; Science Foundation Ireland,
   Ireland [16/ERA-HDHL/3362]; Ministry of Education, University and
   Research (MIUR), Italy [CUP D43C17000100006]; Ministry of Science and
   Research of North Rhine Westphalia, Germany; German Research
   Association; German Federal Ministry of Health; Ministry of Culture and
   Science of the State North Rhine-Westphalia; BMBF; "DietBody-Brain
   (DietBB)" Competence Cluster in Nutrition Research - BMBF [FKZ:
   01EA1809A]; Science Foundation Ireland (SFI) [16/ERA-HDHL/3362] Funding
   Source: Science Foundation Ireland (SFI)
FX The authors would like to appreciate the DONALD study participants and
   their families for their interest, time, commitment, and provision of
   their data. We also acknowledge the support of the staffs at the study
   centre for data collection and processing of urine and blood samples. We
   also thank Stefan Benda for his support in formatting the figures. This
   study was financially supported by the project "Metabolic HEALTH through
   nutrition, microbiota and tryptophan bioMARKers in the frame of the EU
   Joint Programming Initiative "A Healthy Diet for a Healthy Life" (ERA
   HDHL -HEALTHMARK) and the respective national funding organizations: the
   Federal Ministry of Education and Research (BMBF), Germany (grant
   number: 01EA1705A), Science Foundation Ireland, Ireland (grant number,
   16/ERA-HDHL/3362), and the Ministry of Education, University and
   Research (MIUR), Italy (CUP D43C17000100006). The DONALD study is
   supported by the Ministry of Science and Research of North Rhine
   Westphalia, Germany. Biomarker measurements were funded by the German
   Research Association. The German Diabetes Center is funded by the German
   Federal Ministry of Health and the Ministry of Culture and Science of
   the State North Rhine-Westphalia. This study was also supported in part
   by a grant from the BMBF to the German Center for Diabetes Research (DZD
   e.V.). This study was also supported by the "DietBody-Brain (DietBB)"
   Competence Cluster in Nutrition Research funded by the BMBF, FKZ:
   01EA1809A. The funding sources had no influence on study design; in the
   collection, analysis, and interpretation of data; in the writing of the
   report; and in the decision to submit the paper for publication.
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NR 72
TC 16
Z9 17
U1 0
U2 7
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD APR 14
PY 2020
VL 10
IS 1
AR 6399
DI 10.1038/s41598-020-63313-z
PG 13
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA ND8OX
UT WOS:000562163200010
PM 32286421
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Kim, HY
   Okubo, T
   Juneja, LR
   Yokozawa, T
AF Kim, Hyun Young
   Okubo, Tsutomu
   Juneja, Lekh Raj
   Yokozawa, Takako
TI The protective role of amla (Emblica officinalis Gaertn.) against
   fructose-induced metabolic syndrome in a rat model
SO BRITISH JOURNAL OF NUTRITION
LA English
DT Article
DE Amla; High-fructose diet; Metabolic syndrome; Sterol regulatory
   element-binding protein-1; NF-kappa B
ID FACTOR-KAPPA-B; RECEPTOR-ALPHA EXPRESSION; INSULIN-RESISTANCE; OXIDATIVE
   STRESS; ANTIOXIDANT ACTIVITY; CARDIAC-HYPERTROPHY; PHYLLANTHUS-EMBLICA;
   LIPID-PEROXIDATION; DIABETES-MELLITUS; ENDOTHELIAL-CELLS
AB We investigated the effects of amla (Emblica officinalis Gaertn.) on fructose-induced metabolic syndrome using a rat model. Male Wistar rats were fed a high-fructose (65 %) diet or standard chow for I week, and treated with an ethyl acetate (EtOAc) extract of amla, a polyphenol-rich fraction, at 10 or 20 mg/kg body weight per d, or vehicle, for 2 weeks. Serum glucose, TAG, total cholesterol and blood pressure levels of the high-fructose diet-fed rats were increased compared with those of the normal rats (P<0.001). However, the EtOAc extract of amla ameliorated the high fructose-induced metabolic syndrome, including hypertriacylglycerolaemia and hypercholesterolaemia. Also, the elevated levels of hepatic TAG and total cholesterol in rats given the high-fructose diet were significantly reduced by 33-8 and 24-6 %, respectively (P<0.001), on the administration of the EtOAc extract of amla at the dose of 20 mg/kg with the regulation of sterol regulatory element-binding protein (SREBP)-I expression. The protein levels of PPAR alpha. and SREBP-2 were not affected by the feeding of the high-fructose diet or EtOAc extract of amla. In addition, oral administration of the amla extract at the dose of 20 mg/kg significantly inhibited the increased serum and hepatic mitochondrial thiobarbituric acid-reactive substance levels (21.1 and 43.1%, respectively; P<0.001). Furthermore, the amla extract inhibited the increase of cyclo-oxygenase-2 with the regulation of NF-kappa B and bcl-2 proteins in the liver, while the elevated expression level of bax was significantly decreased by 8.5 and 10.2% at the doses of 10 and 20mg/kg body weight per d, respectively. These findings suggest that fructose-induced metabolic syndrome is attenuated by the polyphenol-rich fraction of amla.
C1 [Kim, Hyun Young; Yokozawa, Takako] Toyama Univ, Inst Nat Med, Toyama 9300194, Japan.
   [Kim, Hyun Young] Jinju Natl Univ, Dept Food Sci, Jinju 660758, South Korea.
   [Okubo, Tsutomu; Juneja, Lekh Raj] Taiyo Kagaku Co Ltd, Bionutr Div, Yokaichi 5100844, Japan.
C3 University of Toyama; TAIYO KAGAKU CO., LTD.
RP Yokozawa, T (corresponding author), Toyama Univ, Inst Nat Med, 2630 Sugitani, Toyama 9300194, Japan.
EM yokozawa@inm.u-toyama.ac.jp
FU Ministry of Education, Culture, Sports, Science, and Technology, Japan
   [19500661]; Grants-in-Aid for Scientific Research [19500661] Funding
   Source: KAKEN
FX The present study was supported in part by Grants-in-Aid (C) from the
   Ministry of Education, Culture, Sports, Science, and Technology, Japan
   (no. 19500661 to T. Y.).
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NR 76
TC 70
Z9 75
U1 2
U2 16
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1145
EI 1475-2662
J9 BRIT J NUTR
JI Br. J. Nutr.
PD FEB 28
PY 2010
VL 103
IS 4
BP 502
EP 512
DI 10.1017/S0007114509991978
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 559EM
UT WOS:000274804900006
PM 19878614
OA Bronze
DA 2025-06-11
ER

PT J
AU Nuotio-Antar, AM
   Hachey, DL
   Hasty, AH
AF Nuotio-Antar, Alli M.
   Hachey, David L.
   Hasty, Alyssa H.
TI Carbenoxolone treatment attenuates symptoms of metabolic syndrome and
   atherogenesis in obese, hyperlipidemic mice
SO AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
LA English
DT Article
DE 11 beta-hydroxysteroid dehydrogenase type 1; obesity; agouti;
   low-density; lipoprotein receptor
ID 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1; HEPATIC INSULIN
   SENSITIVITY; GAP-JUNCTIONAL COMMUNICATION; ADIPOSE-TISSUE;
   GLUCOCORTICOID-RECEPTOR; SELECTIVE-INHIBITION; VISCERAL OBESITY; CHRONIC
   STRESS; EXPRESSION; CORTISOL
AB Nuotio-Antar AM, Hachey DL, Hasty AH. Carbenoxolone treatment attenuates symptoms of metabolic syndrome and atherogenesis in obese, hyperlipidemic mice. Am J Physiol Endocrinol Metab 293: E1517-E1528, 2007. First published September 18, 2007; doi: 10.1152/ajpendo.00522.2007. - Glucocorticoids, which are well established to regulate body fat mass distribution, adipocyte lipolysis, hepatic gluconeogenesis, and hepatocyte VLDL secretion, are speculated to play a role in the pathology of metabolic syndrome. Recent focus has been on the activity of 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1), which is capable of regenerating, and thus amplifying, glucocorticoids in key metabolic tissues such as liver and adipose tissue. To determine the effects of global 11 beta-HSD1 inhibition on metabolic syndrome risk factors, we subcutaneously injected "Western"-type diet-fed hyperlipidemic mice displaying moderate or severe obesity [LDL receptor ( LDLR)-deficient (LDLR-/-) mice and mice derived from heterozygous agouti (A(y)/a) and homozygous LDLR-/- breeding pairs (A(y)/a; LDLR-/- mice)] with the nonselective 11 beta-HSD inhibitor carbenoxolone for 4 wk. Body composition throughout the study, end-point fasting plasma, and extent of hepatic steatosis and atherosclerosis were assessed. This route of treatment led to detection of high levels of carbenoxolone in liver and fat and resulted in decreased weight gain due to reduced body fat mass in both mouse models. However, only A(y)/a; LDLR-/- mice showed an effect of 11 beta-HSD1 inhibition on fasting insulin and plasma lipids, coincident with a reduction in VLDL due to mildly increased VLDL clearance and dramatically decreased hepatic triglyceride production. A(y)/a; LDLR-/- mice also showed a greater effect of the drug on reducing atherosclerotic lesion formation. These findings indicate that subcutaneous injection of an 11 beta-HSD1 inhibitor allows for the targeting of the enzyme in not only liver, but also adipose tissue, and attenuates many metabolic syndrome risk factors, with more pronounced effects in cases of severe obesity and hyperlipidemia.
C1 Vanderbilt Univ, Ctr Med, Dept Mol Physiol & Biophys, Nashville, TN 37232 USA.
   Vanderbilt Univ, Ctr Med, Dept Pharmacol, Nashville, TN 37232 USA.
C3 Vanderbilt University; Vanderbilt University
RP Hasty, AH (corresponding author), 702 Light Hall,23rd Ave S, Nashville, TN 37027 USA.
EM alyssa.hasty@vanderbilt.edu
RI Hasty, Alyssa/AAA-2757-2020
OI Hasty, Alyssa/0000-0001-7302-8045; Antar, Alli/0000-0002-1830-4868
FU NIDDK NIH HHS [DK0588404, DK020593, DK-59637] Funding Source: Medline
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NR 61
TC 61
Z9 66
U1 0
U2 8
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0193-1849
EI 1522-1555
J9 AM J PHYSIOL-ENDOC M
JI Am. J. Physiol.-Endocrinol. Metab.
PD DEC
PY 2007
VL 293
IS 6
BP E1517
EP E1528
DI 10.1152/ajpendo.00522.2007
PG 12
WC Endocrinology & Metabolism; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Physiology
GA 239HU
UT WOS:000251510200007
PM 17878220
DA 2025-06-11
ER

PT J
AU Liu, TM
   Xu, Y
   Yi, CX
   Tong, QC
   Cai, DS
AF Liu, Tiemin
   Xu, Yong
   Yi, Chun-Xia
   Tong, Qingchun
   Cai, Dongsheng
TI The hypothalamus for whole-body physiology: from metabolism to aging
SO PROTEIN & CELL
LA English
DT Review
DE neuron; metabolism; hypothalamus; obesity; aging
ID ESTROGEN-RECEPTOR-ALPHA; HIGH-FAT-DIET; NF-KAPPA-B;
   NUCLEUS-TRACTUS-SOLITARIUS; DEPRESSION-LIKE BEHAVIORS; NEURONS REGULATE
   ENERGY; SEROTONIN 2C RECEPTORS; CENTRAL-NERVOUS-SYSTEM; BROWN
   ADIPOSE-TISSUE; DORSAL RAPHE NUCLEUS
AB Obesity and aging are two important epidemic factors for metabolic syndrome and many other health issues, which contribute to devastating diseases such as cardiovascular diseases, stroke and cancers. The brain plays a central role in controlling metabolic physiology in that it integrates information from other metabolic organs, sends regulatory projections and orchestrates the whole-body function. Emerging studies suggest that brain dysfunction in sensing various internal cues or processing external cues may have profound effects on metabolic and other physiological functions. This review highlights brain dysfunction linked to genetic mutations, sex, brain inflammation, microbiota, stress as causes for whole-body pathophysiology, arguing brain dysfunction as a root cause for the epidemic of aging and obesity-related disorders. We also speculate key issues that need to be addressed on how to reveal relevant brain dysfunction that underlines the development of these disorders and diseases in order to develop new treatment strategies against these health problems.
C1 [Liu, Tiemin] Fudan Univ, Inst Metab & Integrat Biol, State Key Lab Genet Engn, Dept Endocrinol & Metab,Human Phenome Inst, Shanghai 200438, Peoples R China.
   [Liu, Tiemin] Fudan Univ, Collaborat Innovat Ctr Genet & Dev, Zhongshan Hosp, Sch Life Sci, Shanghai 200438, Peoples R China.
   [Xu, Yong] Baylor Coll Med, Dept Pediat, Dept Mol & Cellular Biol, Childrens Nutr Res Ctr, One Baylor Plaza, Houston, TX 77030 USA.
   [Yi, Chun-Xia] Univ Amsterdam, Dept Endocrinol & Metab, Amsterdam Univ Med Ctr, Amsterdam Gastroenterol Endocrinol Metab, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands.
   [Tong, Qingchun] Univ Texas McGovern Med Sch, Dept Neurobiol & Anat, Brown Fdn Inst Mol Med, Grad Program Neurosci MD Anderson UTHlth Gr, Houston, TX 77030 USA.
   [Cai, Dongsheng] Albert Einstein Coll Med, Dept Mol Pharmacol, Bronx, NY 10461 USA.
C3 Fudan University; Fudan University; Baylor College of Medicine;
   University of Amsterdam; Montefiore Medical Center; Albert Einstein
   College of Medicine; Yeshiva University
RP Liu, TM (corresponding author), Fudan Univ, Inst Metab & Integrat Biol, State Key Lab Genet Engn, Dept Endocrinol & Metab,Human Phenome Inst, Shanghai 200438, Peoples R China.; Liu, TM (corresponding author), Fudan Univ, Collaborat Innovat Ctr Genet & Dev, Zhongshan Hosp, Sch Life Sci, Shanghai 200438, Peoples R China.; Tong, QC (corresponding author), Univ Texas McGovern Med Sch, Dept Neurobiol & Anat, Brown Fdn Inst Mol Med, Grad Program Neurosci MD Anderson UTHlth Gr, Houston, TX 77030 USA.; Cai, DS (corresponding author), Albert Einstein Coll Med, Dept Mol Pharmacol, Bronx, NY 10461 USA.
EM tiemin_liu@fudan.edu.cn; qingchun.tong@uth.tmc.edu;
   dongsheng.cai@einsteinmed.org
RI Cai, Dongsheng/CAH-8271-2022; çŽ‹, æ/AAU-6965-2020; Yi,
   Chun-Xia/J-4068-2016
OI Xu, Yong/0000-0002-4908-1572; Liu, Tiemin/0000-0003-2077-7653; Yi,
   Chun-Xia/0000-0003-1184-4615; Tong, Qingchun/0000-0002-4561-2540
FU National Key RAMP;D Program of China [2019YFA0801900, 2018YFA0800300];
   National Natural Science Foundation of China [91749104, 31971074];
   Science and Technology Innovation Action Plan of Shanghai Science and
   Technology Committee [18140901300]; Open Research Fund of the National
   Key Laboratory of Genetic Engineering [SKLGE1803]; Shanghai Pujiang
   Talent Project [18PJ1400700]
FX We apologize for not being able to cite many additional important
   contributions from peers due to space limitation. This study was funded
   by the National Key R&D Program of China
   (2019YFA0801900,2018YFA0800300), the National Natural Science Foundation
   of China (91749104 and 31971074), the Science and Technology Innovation
   Action Plan of Shanghai Science and Technology Committee (18140901300),
   the Open Research Fund of the National Key Laboratory of Genetic
   Engineering (SKLGE1803), the Shanghai Pujiang Talent Project
   (18PJ1400700) to T.L., and Dr. Tong is the holder of Cullen Chair in
   Molecular Medicine at McGovern Medical School of UTHealth.
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NR 318
TC 68
Z9 73
U1 2
U2 35
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1674-800X
EI 1674-8018
J9 PROTEIN CELL
JI Protein Cell
PD JUN
PY 2022
VL 13
IS 6
BP 394
EP 421
DI 10.1007/s13238-021-00834-x
EA APR 2021
PG 28
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA 1D6BF
UT WOS:000637685700001
PM 33826123
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Sági, B
   Késoi, I
   Vas, T
   Csiky, B
   Nagy, J
   Kovács, T
AF Sagi, Balazs
   Kesoi, Istvan
   Vas, Tibor
   Csiky, Botond
   Nagy, Judit
   Kovacs, Tibor
TI The prognostic role of heart rate recovery after exercise and metabolic
   syndrome in IgA nephropathy
SO BMC NEPHROLOGY
LA English
DT Article
DE Heart rate recovery; Chronic kidney disease; IgA nephropathy; Renal
   function; Cardiovascular risk
ID CHRONIC KIDNEY-DISEASE; ENDOTHELIAL DYSFUNCTION; CARDIOVASCULAR-DISEASE;
   ASSOCIATION; PREDICTOR; MORTALITY; CAPACITY; MEN; HYPERGLYCEMIA;
   INFLAMMATION
AB Background Cardiovascular (CV) morbidity and mortality are higher in chronic kidney disease (CKD) than in the general population. Reduced heart rate recovery (HRR) is an independent risk factor for CV disease. The aim of the study was to determine the prognostic role of HRR in a homogenous group of CKD patients. Methods One hundred and twenty-five IgA nephropathy patients (82 male, 43 female, age 54.7 +/- 13 years) with CKD stage 1-4 were investigated and followed for average 70 months. We performed a graded exercise treadmill stress test. HRR was derived from the difference of the peak heart rate and the heart rate at 1 min after exercise. Patients were divided into two groups by the mean HRR value (22.9 beats/min). The composite (CV and renal) endpoints included all-cause mortality and any CV event such as stroke, myocardial infarction, revascularisation (CV) and end-stage renal disease, renal replacement therapy (renal). Results Patients with reduced HRR (< 23 bpm) had significantly more end point events (22/62 patients vs. 9/53 patients, p = 0.013) compared to the higher HRR (>= 23 bpm). Of the secondary the endpoints (CV or renal separately) rate of the renal endpoint was significantly higher in the lower HRR group (p = 0.029), while there was no significant difference in the CV endpoint between the two HRR groups (p = 0.285). Independent predictors of survival were eGFR and diabetes mellitus by using Cox regression analysis. Kaplan-Meier curves showed significant differences in metabolic syndrome and non-metabolic syndrome when examined at the combined endpoints (cardiovascular and renal) or at each endpoint separately. The primary endpoint rate was increased significantly with the increased number of metabolic syndrome component (Met.sy. comp. 0 vs. Met. sy. comp. 2+, primary endpoints, p = 0.012). Conclusion Our results showed that reduced HRR measured by treadmill exercise test has a predictive value for the prognosis of IgA nephropathy. The presence of metabolic syndrome may worsen the prognosis of IgA nephropathy.
C1 [Sagi, Balazs; Vas, Tibor; Csiky, Botond; Nagy, Judit; Kovacs, Tibor] Univ Pecs, Diabetol Ctr, Clin Ctr Med Sch, Dept Internal Med & Nephrol 2, Pacsirta St 1, H-7624 Pecs, Hungary.
   [Sagi, Balazs; Csiky, Botond] Fresenius Med Care Dialysis Ctr Pecs, Pecs, Hungary.
   [Kesoi, Istvan] Min Rehabil & Nighttime Sanat, Internal Med Dept, Hlth Ctr Komlo, Komlo, Hungary.
C3 University of Pecs
RP Nagy, J (corresponding author), Univ Pecs, Diabetol Ctr, Clin Ctr Med Sch, Dept Internal Med & Nephrol 2, Pacsirta St 1, H-7624 Pecs, Hungary.
EM judit.nagy@aok.pte.hu
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NR 50
TC 2
Z9 2
U1 0
U2 3
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2369
J9 BMC NEPHROL
JI BMC Nephrol.
PD NOV 23
PY 2021
VL 22
IS 1
AR 390
DI 10.1186/s12882-021-02596-4
PG 11
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA XB8PJ
UT WOS:000721584700001
PM 34809611
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Vareka, T
   Vecka, M
   Jirák, R
   Tvrzická, E
   Macásek, J
   Zák, A
   Zeman, M
AF Vareka, Tomas
   Vecka, Marek
   Jirak, Roman
   Tvrzicka, Eva
   Macasek, Jaroslav
   Zak, Ales
   Zeman, Miroslav
TI Plasma fatty acid profile in depressive disorder resembles insulin
   resistance state
SO NEUROENDOCRINOLOGY LETTERS
LA English
DT Article
DE fatty acids; depressive disorder; insulin resistance; delta-6-desaturase
ID CORONARY-HEART-DISEASE; METABOLIC SYNDROME; OXIDATIVE STRESS
AB BACKGROUND: Depressive disorder is related to an increased risk of type 2 diabetes mellitus (DM2) and cardiovascular disease (CVD). Insulin resistance (IR), connected with altered fatty acid (FA) composition, namely with decreased proportion of polyunsaturated FA could participate in these associations. The aim of the study was to investigate the composition of FA in plasma cholesterol esters (CE) and phosphatidylcholine (PC) as well as indices of insulin resistance and oxidative stress in the patients with depressive disorder.
   MATERIALS AND METHODS: Parameters of lipid and glucose homeostasis, concentrations of FA in plasma cholesteryl esters (CE) and phosphatidylcholine (PC) and conjugated dienes in LDL were investigated in a group of 47 patients (9M/38F) with depression and compared with 47 control persons (16M/31F). Delta-9 desaturase (D9D) and D6D desaturase were estimated as product to precursor fatty acid ratios.
   RESULTS: In depressive patients increased concentrations of palmitoleic acid and total monounsaturated FA with decreased proportion of total polyunsaturated FA n-6 (PUFA n-6) (all p<0.05) in CE were found, while in PC increased proportion of saturated FA was observed (p<0.05). Moreover, index of D6D activity was significantly increased in PC and CE (p<0.05). Concomitantly, in depressive patients higher levels of plasma triacylglycerols (p<0.05), conjugated dienes in LDL (p<0.001) and HOMA index of IR (p<0.05) were found.
   CONCLUSIONS: Esterified FA composition of depressive patients revealed changes, similar to those, usually observed in insulin resistance. Dysregulation of FA could participate in the pathogenesis of depression and be associated with an increased risk of CVD and DM2.
C1 [Vareka, Tomas; Vecka, Marek; Tvrzicka, Eva; Macasek, Jaroslav; Zak, Ales; Zeman, Miroslav] Charles Univ Prague, Fac Med 1, Dept Internal Med 4, Prague 12808 2, Czech Republic.
   [Jirak, Roman] Charles Univ Prague, Fac Med 1, Dept Psychiat, Prague 12808 2, Czech Republic.
C3 Charles University Prague; Charles University Prague; General University
   Hospital Prague
RP Zeman, M (corresponding author), Charles Univ Prague, Fac Med 1, Dept Internal Med 4, U Nemocnice 2, Prague 12808 2, Czech Republic.
EM mirozem@seznam.cz
RI Vareka, Tomas/B-5246-2017; Vecka, Marek/A-3560-2008; Zak,
   Ales/G-8318-2016; Zeman, Miroslav/J-5281-2016; Macasek,
   Jaroslav/G-8337-2016; Tvrzicka, Eva/Q-6300-2016; Jirak,
   Roman/O-1658-2017
OI Vareka, Tomas/0000-0001-5390-8272; Vecka, Marek/0000-0002-3269-1817;
   Zak, Ales/0000-0002-1698-6068; Zeman, Miroslav/0000-0001-5338-603X;
   Macasek, Jaroslav/0000-0002-8009-8970; Tvrzicka,
   Eva/0000-0003-0794-8454; Jirak, Roman/0000-0002-8061-9668
FU IGA Ministry of Health, The Czech Republic [NT/13199]; Charles
   University in Prague, 1st Faculty of Medicine [PRVOUK-P25/LF1/2]
FX The study was supported by the grant NT/13199, IGA Ministry of Health,
   The Czech Republic and by the Research project of Charles University in
   Prague, 1st Faculty of Medicine - PRVOUK-P25/LF1/2.
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NR 13
TC 12
Z9 12
U1 0
U2 7
PU MAGHIRA & MAAS PUBLICATIONS
PI MUNSBACH
PA MAGHIRA & MAAS S A R L, 6C, RUE GABRIEL LIPPMANN, L-5365 MUNSBACH,
   LUXEMBOURG
SN 0172-780X
EI 2354-4716
J9 NEUROENDOCRINOL LETT
JI Neuroendocrinol. Lett.
PY 2012
VL 33
SU 2
BP 83
EP 86
PG 4
WC Endocrinology & Metabolism; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology
GA 052CN
UT WOS:000312175400016
PM 23183516
DA 2025-06-11
ER

PT J
AU Armon, G
   Shirom, A
   Berliner, S
   Shapira, I
   Melamed, S
AF Armon, Galit
   Shirom, Arie
   Berliner, Shlomo
   Shapira, Itzhak
   Melamed, Samuel
TI A prospective study of the association between obesity and burnout among
   apparently healthy men and women
SO JOURNAL OF OCCUPATIONAL HEALTH PSYCHOLOGY
LA English
DT Article
DE obesity; burnout; prospective design; gender difference; depression
ID BODY-MASS-INDEX; STRESS-INDUCED CORTISOL; 3RD NATIONAL-HEALTH;
   RISK-FACTORS; DEPRESSIVE SYMPTOMS; WAIST CIRCUMFERENCE; METABOLIC
   SYNDROME; VITAL EXHAUSTION; WEIGHT-GAIN; PSYCHOLOGICAL WORKLOAD
AB The authors prospectively tested the hypothesis that obesity predicts burnout and the reverse-causation hypothesis that burnout predicts obesity. Respondents were 724 men and 340 women, apparently healthy employees, who underwent routine periodic health examinations at 2 points of time about 18 months apart. Obesity was assessed by body mass index, waist-hip ratio, and waist circumference. In regression analyses, done separately for men and women, the authors controlled for depressive symptomatology, sport activity, and Time I levels of the criterion. The hypothesis that burnout predicts obesity was not supported. The authors found that Time I measures of obesity predicted reductions rather than the hypothesized elevations of Time 2 burnout levels. The authors also found that for male respondents with relatively higher levels of Time 1 burnout, the higher their level of Time I obesity measure, the lower their level of T2 burnout.
C1 [Armon, Galit; Shirom, Arie] Tel Aviv Univ, Fac Management, IL-69978 Tel Aviv, Israel.
   [Berliner, Shlomo; Shapira, Itzhak] Tel Aviv Sourasky Med Ctr, Tel Aviv, Israel.
   [Berliner, Shlomo; Shapira, Itzhak] Tel Aviv Univ, Sackler Fac Med, IL-69978 Tel Aviv, Israel.
   [Melamed, Samuel] Tel Aviv Univ, Sackler Fac Med, Dept Epidemiol & Prevent Med, IL-69978 Tel Aviv, Israel.
C3 Tel Aviv University; Tel Aviv University; Sackler Faculty of Medicine;
   Tel Aviv Sourasky Medical Center; Tel Aviv University; Sackler Faculty
   of Medicine; Tel Aviv University; Sackler Faculty of Medicine
RP Shirom, A (corresponding author), Tel Aviv Univ, Fac Management, Ramat Aviv,POB 39010, IL-69978 Tel Aviv, Israel.
EM ashirom@post.tau.ac.il
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NR 89
TC 33
Z9 40
U1 0
U2 19
PU EDUCATIONAL PUBLISHING FOUNDATION-AMERICAN PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST, NE, WASHINGTON, DC 20002-4242 USA
SN 1076-8998
EI 1939-1307
J9 J OCCUP HEALTH PSYCH
JI J. Occup. Health Psychol.
PD JAN
PY 2008
VL 13
IS 1
BP 43
EP 57
DI 10.1037/1076-8998.13.1.43
PG 15
WC Public, Environmental & Occupational Health; Psychology, Applied
WE Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; Psychology
GA 254VI
UT WOS:000252615700005
PM 18211168
DA 2025-06-11
ER

PT J
AU Shi, ZM
   Tuomilehto, J
   Kronfeld-Schor, N
   Alberti, G
   Stern, N
   El-Osta, A
   Chai, ZL
   Bilu, C
   Einat, H
   Zimmet, P
AF Shi, Zumin
   Tuomilehto, Jaakko
   Kronfeld-Schor, Noga
   Alberti, George
   Stern, Naftali
   El-Osta, Assam
   Chai, Zhonglin
   Bilu, Carmel
   Einat, Haim
   Zimmet, Paul
TI The Circadian Syndrome Is a Significant and Stronger Predictor for
   Cardiovascular Disease than the Metabolic Syndrome-The NHANES Survey
   during 2005-2016
SO NUTRIENTS
LA English
DT Article
DE circadian syndrome; metabolic syndrome; cardiovascular disease; adults;
   NHANES
ID UNITED-STATES; SLEEP; PREVALENCE; CONSEQUENCES; MORTALITY; VALIDITY;
   GENETICS; RISK
AB The study aimed to compare the predictive value of the Circadian Syndrome (CircS) and Metabolic Syndrome (MetS) for cardiovascular disease (CVD). We used data of 12,156 adults aged >= 20 years who attended National Health and Nutrition Examination Survey (NHANES) 2005-2016. Mortality was obtained from the registry updated to 2019. The CircS was defined based on components of the MetS, in addition to short sleep and depression. Both the MetS and CircS were directly associated with self-reported history of CVD. The odds ratios for prevalent CVD associated with the CircS and MetS, respectively, were 2.92 (95% confidence interval (CI) 2.21-3.86) and 3.20 (2.38-4.30) in men, and 3.27 (2.34-4.59) and 3.04 (2.15-4.30) in women. The CircS had a better predictive power for prevalent CVD than that of MetS, as indicated by the higher positive predictive value (PPV); in men, the PPV for prevalent CVD with CircS was 23.1% and with MetS 20.9%, and in women these were 17.9% vs. 16.4%, respectively. However, the PPV of the CircS and MetS did not differ for the CVD mortality prediction. Women with CircS alone had a higher risk for both prevalent CVD and CVD mortality than those with MetS alone. In conclusion, the CircS is a significant and stronger predictor for CVD than the MetS in US adults.
C1 [Shi, Zumin] Qatar Univ, Coll Hlth Sci, Human Nutr Dept, QU Hlth, Doha 2713, Qatar.
   [Tuomilehto, Jaakko] Univ Helsinki, Dept Publ Hlth, Helsinki 00014, Finland.
   [Tuomilehto, Jaakko] Finnish Inst Hlth & Welf, Populat Hlth Unit, Helsinki 00280, Finland.
   [Tuomilehto, Jaakko] King Abdulaziz Univ, Saudi Diabet Res Grp, Jeddah 21589, Saudi Arabia.
   [Kronfeld-Schor, Noga; Bilu, Carmel] Tel Aviv Univ, Sch Zool, IL-6997801 Tel Aviv, Israel.
   [Alberti, George] Imperial Coll London, Dept Endocrinol & Metab, London SW7 2BX, England.
   [Stern, Naftali; Zimmet, Paul] Tel Aviv Med Ctr & Sch Med, Sagol Ctr Epigenet Aging & Metab, IL-6997801 Tel Aviv, Israel.
   [Stern, Naftali] Tel Aviv Univ, Sackler Fac Med, IL-6997801 Tel Aviv, Israel.
   [Stern, Naftali] Tel Aviv Univ, Sagol Sch Neurosci, IL-6997801 Tel Aviv, Israel.
   [El-Osta, Assam; Chai, Zhonglin; Zimmet, Paul] Monash Univ, Cent Clin Sch, Dept Diabet, Melbourne, Vic 3004, Australia.
   [El-Osta, Assam] Chinese Univ Hong Kong, Hong Kong Inst Diabet & Obes, Hong Kong, Peoples R China.
C3 Qatar University; University of Helsinki; King Abdulaziz University; Tel
   Aviv University; Imperial College London; Tel Aviv University; Sackler
   Faculty of Medicine; Tel Aviv University; Sackler Faculty of Medicine;
   Tel Aviv University; Monash University; Chinese University of Hong Kong
RP Shi, ZM (corresponding author), Qatar Univ, Coll Hlth Sci, Human Nutr Dept, QU Hlth, Doha 2713, Qatar.
EM zumin@qu.edu.qa
RI Shi, Zumin/A-1093-2009; CHAI, ZHONGLIN/X-1342-2019; Zimmet,
   Paul/H-7635-2013; tuomilehto, jaakko/E-6504-2011; Kronfeld-Schor,
   Noga/AAU-3792-2020
OI Chai, Zhonglin/0000-0001-8182-8579; El-Osta, Assam/0000-0001-7968-7375;
   Shi, Zumin/0000-0002-3099-3299; El-Osta, Assam/0000-0003-2969-9137;
   Kronfeld-Schor, Noga/0000-0002-5224-3341
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NR 39
TC 19
Z9 20
U1 7
U2 26
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD DEC
PY 2022
VL 14
IS 24
AR 5317
DI 10.3390/nu14245317
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 7G7QN
UT WOS:000902713900001
PM 36558476
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Malkowska, P
AF Malkowska, Paulina
TI Positive Effects of Physical Activity on Insulin Signaling
SO CURRENT ISSUES IN MOLECULAR BIOLOGY
LA English
DT Review
DE physical activity; insulin sensitivity; metabolic health; inflammation;
   insulin signaling; exercise interventions; type 2 diabetes; metabolic
   syndrome
ID HORMONE-SENSITIVE LIPASE; BETA-CELL FUNCTION; STIMULATED GLUCOSE-UPTAKE;
   ACTIVATED PROTEIN-KINASE; SKELETAL-MUSCLE; ADIPOSE-TISSUE; METABOLIC
   SYNDROME; GLYCOGEN-SYNTHASE; TRANSCRIPTION FACTORS; RADICAL GENERATION
AB Physical activity is integral to metabolic health, particularly in addressing insulin resistance and related disorders such as type 2 diabetes mellitus (T2DM). Studies consistently demonstrate a strong association between physical activity levels and insulin sensitivity. Regular exercise interventions were shown to significantly improve glycemic control, highlighting exercise as a recommended therapeutic strategy for reducing insulin resistance. Physical inactivity is closely linked to islet cell insufficiency, exacerbating insulin resistance through various pathways including ER stress, mitochondrial dysfunction, oxidative stress, and inflammation. Conversely, physical training and exercise preserve and restore islet function, enhancing peripheral insulin sensitivity. Exercise interventions stimulate beta-cell proliferation through increased circulating levels of growth factors, further emphasizing its role in maintaining pancreatic health and glucose metabolism. Furthermore, sedentary lifestyles contribute to elevated oxidative stress levels and ceramide production, impairing insulin signaling and glucose metabolism. Regular exercise induces anti-inflammatory responses, enhances antioxidant defenses, and promotes mitochondrial function, thereby improving insulin sensitivity and metabolic efficiency. Encouraging individuals to adopt active lifestyles and engage in regular exercise is crucial for preventing and managing insulin resistance and related metabolic disorders, ultimately promoting overall health and well-being.
C1 [Malkowska, Paulina] Univ Szczecin, Inst Phys Culture Sci, PL-71065 Szczecin, Poland.
C3 University of Szczecin
RP Malkowska, P (corresponding author), Univ Szczecin, Inst Phys Culture Sci, PL-71065 Szczecin, Poland.
EM paulina.malkowska@usz.edu.pl
RI Niedźwiedzka-Rystwej, Paulina/T-6496-2019
OI Malkowska, Paulina/0000-0003-2430-5020
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NR 161
TC 14
Z9 14
U1 1
U2 1
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1467-3037
EI 1467-3045
J9 CURR ISSUES MOL BIOL
JI Curr. Issues Mol. Biol.
PD JUN
PY 2024
VL 46
IS 6
BP 5467
EP 5487
DI 10.3390/cimb46060327
PG 21
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA WJ1V3
UT WOS:001254421000001
PM 38920999
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Uçkan, K
   Demir, H
   Turan, K
   Sarikaya, E
   Demir, C
AF Uckan, Kazim
   Demir, Halit
   Turan, Kasim
   Sarikaya, Eren
   Demir, Canan
TI Role of Oxidative Stress in Obese and Nonobese PCOS Patients
SO INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
LA English
DT Article
ID POLYCYSTIC-OVARY-SYNDROME; INSULIN-RESISTANCE; ENDOTHELIAL DYSFUNCTION;
   WOMEN; RISK; YOUNG; MALONDIALDEHYDE; ANTIOXIDANTS; PREVALENCE; CONSENSUS
AB Objective. The aim of this study was to evaluate the relationship between the oxidant-antioxidant status, endothelial dysfunction, lipid metabolism, and metabolic syndrome risk in women with polycystic ovary syndrome (PCOS). Materials and Methods. Forty-five obese (BMI > 30 kg/m2) woman diagnosed with PCOS in the study, forty-five nonobese (BMI < 30 kg/m(2)) PCOS diagnosis working groups, and forty-nine healthy control groups were created with patients. Serum malondialdehyde (MDA) levels with antioxidant activities, such as SOD, GSH, GPx, and CAT activities, were measured by spectrophotometry. Results. There was a statistically significant difference in the mean serum MDA level in the obese PCOS group compared to the nonobese group and the control group (p < 0.001). When the antioxidant parameters, such as SOD, GPx, GSH, and CAT, were compared with the healthy control group, nonobese, and obese PCOS groups, the difference between the groups was statistically significant (p < 0.001). A positive correlation was observed between MDA and BMI, triglyceride, LDL, SBP, DBP, and HOMA-IR in the PCOS patient group. Conclusion. Oxidative stress and decreased antioxidant parameters in PCOS patients were correlated with hyperinsulinemia, hypertension, and dyslipidemia findings, and we think that this oxidative stress condition may contribute to metabolic syndrome and cardiovascular diseases in PCOS patients.
C1 [Uckan, Kazim] Van Training & Res Hosp, Dept Obstet & Gynecol, Van, Turkey.
   [Demir, Halit] Van Yuzuncu Yil Univ, Dept Biochem, Van, Turkey.
   [Turan, Kasim; Sarikaya, Eren] Clin Obstet & Gynecol Dr KasimTuran, Van, Turkey.
   [Demir, Canan] Van Yuzuncu Yil Univ, Vocat Sch Hlth Serv, Van, Turkey.
C3 Van Training & Research Hospital; Yuzuncu Yil University; Yuzuncu Yil
   University
RP Uçkan, K (corresponding author), Van Training & Res Hosp, Dept Obstet & Gynecol, Van, Turkey.
EM druckan65@hotmail.com
RI DEMIR, Canan/GWM-8855-2022; Sarikaya, Eren/GWZ-7526-2022
OI DEMIR, Canan/0000-0002-4204-9756; Sarikaya, Eren/0000-0002-5644-0713
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NR 53
TC 49
Z9 51
U1 3
U2 12
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1368-5031
EI 1742-1241
J9 INT J CLIN PRACT
JI Int. J. Clin. Pract.
PD FEB 9
PY 2022
VL 2022
AR 4579831
DI 10.1155/2022/4579831
PG 9
WC Medicine, General & Internal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Pharmacology & Pharmacy
GA 0B8UD
UT WOS:000774902200001
PM 35685525
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Page, S
   Chandhoke, V
   Baranova, A
AF Page, S.
   Chandhoke, V.
   Baranova, A.
TI Melanin and melanogenesis in adipose tissue: possible mechanisms for
   abating oxidative stress and inflammation?
SO OBESITY REVIEWS
LA English
DT Review
DE Melanin; metabolic syndrome; inflammation; obesity
ID MELANOCYTE-STIMULATING HORMONE; GENE-ENVIRONMENT INTERACTION;
   ELECTRON-SPIN-RESONANCE; FATTY LIVER-DISEASE; ALPHA-MSH; METABOLIC
   SYNDROME; INSULIN-RESISTANCE; MELANOCORTIN-1 RECEPTOR;
   PLASMA-CONCENTRATIONS; SYNTHETIC MELANINS
AB P>Obesity has become a worldwide epidemic and can lead to multiple chronic diseases. Adipose tissue is increasingly thought to play an active role in obesity-related pathologies such as insulin resistance and non-alcoholic fatty liver disease. Obesity has been strongly associated with systemic inflammation and, to a lesser degree, with oxidative stress, although the causal relationships among these factors are unclear. A recent study demonstrating an expression of the components of the melanogenic pathway and the presence of melanin in visceral adipose has raised questions regarding the possible role of melanogenesis in adipose tissue. As this study also found larger amounts of melanin in the adipose tissue of obese patients relative to lean ones, we hypothesize that melanin, a pigment known for its antioxidant and anti-inflammatory properties, may scavenge reactive oxygen species and abate oxidative stress and inflammation in adipose tissue. This review considers the evidence to support such a hypothesis, and speculates on the role of melanin within adipocytes. Furthermore, we consider whether the alpha-melanocyte-stimulating hormone or its synthetic analogues could be used to stimulate melanin production in adipocytes, should the hypothesis be supported in future experiments.
C1 [Page, S.; Chandhoke, V.; Baranova, A.] George Mason Univ, Dept Mol & Microbiol, Coll Sci, Fairfax, VA 22030 USA.
   [Page, S.; Baranova, A.] Inova Fairfax Hosp, Ctr Liver Dis, Falls Church, VA USA.
C3 George Mason University; Inova Fairfax Hospital
RP Baranova, A (corresponding author), George Mason Univ, Dept Mol & Microbiol, Coll Sci, David King Hall,MSN 3E1, Fairfax, VA 22030 USA.
EM abaranov@gmu.edu
RI Baranova, Ancha/B-4608-2012
OI Baranova, Ancha/0000-0001-6810-5982
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NR 100
TC 50
Z9 58
U1 1
U2 23
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1467-7881
J9 OBES REV
JI Obes. Rev.
PD MAY
PY 2011
VL 12
IS 501
BP e21
EP e31
DI 10.1111/j.1467-789X.2010.00773.x
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 752JN
UT WOS:000289687500005
PM 20576005
DA 2025-06-11
ER

PT J
AU Yang, M
   Xu, HY
   Yang, L
   Jiang, JJ
   Dong, BR
AF Yang, Ming
   Xu, Hanyue
   Yang, Ling
   Jiang, Jiaojiao
   Dong, Birong
TI Metabolic syndrome and disability in Chinese nonagenarians and
   centenarians
SO AGING CLINICAL AND EXPERIMENTAL RESEARCH
LA English
DT Article
DE Activities of daily living; Disability; Metabolic syndrome
ID GENDER-DIFFERENCES; PREVALENCE; DECLINE; HEALTH; INTERLEUKIN-6;
   ASSOCIATION; DEPRESSION; DISEASE; IMPACT; LIFE
AB Background Little is known about the relationship between metabolic syndrome (MetS) and disability in the oldest old.
   Aims To investigate the possible association between MetS and disability among community-dwelling older adults aged >= 90 years.
   Methods This was a secondary analysis of a cross-sectional study. MetS was defined by the International Diabetes Federation Criteria. Activities of daily living (ADL) and instrumental activities of daily living (IADL) disabilities were evaluated using the physical self-maintenance scale and the Lawton-Brody IADL scale, respectively.
   Results We included 725 participants (mean age: 93.8 +/- 3.1 years). The prevalence of MetS was 13.0% in women and 9.8% in men, respectively. In women, ADL and IADL disabilities were more prevalent in the MetS group compared with the non-MetS group (ADL: 43.1 vs. 30.6%, p = 0.044; IADL: 73.8 vs. 59.8%, p = 0.030). After adjusting for relevant confounders, participants with MetS was associated with an increased risk of either ADL (odds ratio [OR] 1.81, 95% confidence interval [CI] 1.22-3.45) or IADL disability (OR 2.12, 95% CI 1.31-4.78) compared with those without MetS. In men, similar results were found with respect to the prevalence of ADL or IADL disability and the adjusted ORs, but the results were not statistically significant.
   Conclusion MetS is associated with an increased risk of either ADL or IADL disability in a study population of long-lived adults, especially in women.
C1 [Yang, Ming; Dong, Birong] Sichuan Univ, West China Hosp, Ctr Gerontol & Geriatr, 37 Guoxue Lane, Chengdu, Sichuan, Peoples R China.
   [Xu, Hanyue] Sichuan Univ, West China Sch Med, 37 Guoxue Lane, Chengdu, Sichuan, Peoples R China.
   [Yang, Ling] Sichuan Univ, West China Hosp, Outpatient Dept, 37 Guoxue Lane, Chengdu, Sichuan, Peoples R China.
   [Jiang, Jiaojiao] Sichuan Univ, West China Hosp, Ctr Rehabil, 37 Guoxue Lane, Chengdu, Sichuan, Peoples R China.
C3 Sichuan University; Sichuan University; Sichuan University; Sichuan
   University
RP Yang, M (corresponding author), Sichuan Univ, West China Hosp, Ctr Gerontol & Geriatr, 37 Guoxue Lane, Chengdu, Sichuan, Peoples R China.
EM yangmier@gmail.com
RI Yang, Ming/A-4973-2014
OI Yang, Ming/0000-0002-1875-1692
FU Construction Fund for Subjects of West China Hospital of Sichuan
   University [XK05001] Funding Source: Medline; the project of Science and
   Technology Bureau of Sichuan Province [2006Z09-006-4] Funding Source:
   Medline; the Sichuan Provincial Science and Technology Department
   [2016JY0058] Funding Source: Medline
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NR 34
TC 5
Z9 7
U1 0
U2 13
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1594-0667
EI 1720-8319
J9 AGING CLIN EXP RES
JI Aging Clin. Exp. Res.
PD AUG
PY 2018
VL 30
IS 8
BP 943
EP 949
DI 10.1007/s40520-017-0877-6
PG 7
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA GO1UR
UT WOS:000439744400007
PM 29235077
OA Green Published
DA 2025-06-11
ER

PT J
AU Gholami, A
   Doustmohammadian, A
   Shamshirgaran, SM
   Aminisani, N
   Azimi-Nezhad, M
   Abasi, H
   Hariri, M
AF Gholami, Ali
   Doustmohammadian, Azam
   Shamshirgaran, Seyed Morteza
   Aminisani, Nayyereh
   Azimi-Nezhad, Mohsen
   Abasi, Hamid
   Hariri, Mitra
TI Association Between Metabolic Syndrome and Health-Related Quality of
   Life in Older Adults: Findings from the IRanian Longitudinal Study on
   Ageing
SO METABOLIC SYNDROME AND RELATED DISORDERS
LA English
DT Article
DE metabolic syndrome; quality of life; aged
ID SELF-RATED HEALTH; SLEEP DURATION; DEPRESSION; DIAGNOSIS; OBESITY
AB Objectives: There are some studies without consensus on the association between metabolic syndrome (MetS) and health-related quality of life (HRQoL) and few studies among elderly participants; therefore, the aim of this study is evaluating the association between MetS and HRQoL between elderly participants after adjusting for possible confounding factors.Methods: A cross-sectional analysis was conducted with the data from baseline phase of the IRanian Longitudinal Study on Ageing. The MetS diagnosis was conducted based on the National Cholesterol Education Program Adult Treatment Panel III guidelines. The participants were 3452 subjects aged >= 60 years with and without MetS. The Prospective Epidemiological Research Studies in Iran version of the SF-12 questionnaire was used to examine subjects' perspectives on their well-being and general health level. The association between MetS and HRQoL was evaluated through multivariable linear regression model after adjusting for possible covariates.Results: MetS independently had an inverse association with subscales of HRQoL including physical functioning, physical problems, general health, social functioning, and emotional problems, even after fully adjusting for studied confounding factors. An inverse association was also observed between MetS and both mental component summary and physical component summary in the fully adjusted model.Conclusion: Older adults with MetS had a relatively worse physical and mental HRQoL in comparison with individuals without MetS. Independent of any underlying factors, the inverse association of MetS with HRQoL emphasizes the necessity of routine screening and treatment of MetS in older populations.
C1 [Gholami, Ali; Hariri, Mitra] Neyshabur Univ Med Sci, Noncommunicable Dis Res Ctr, Janbazan Ave, Neyshabur 1413993186, Iran.
   [Gholami, Ali] Neyshabur Univ Med Sci, Sch Publ Hlth, Dept Epidemiol & Biostat, Neyshabur, Iran.
   [Doustmohammadian, Azam] Iran Univ Med Sci, Firoozgar Hosp, Gastrointestinal & Liver Dis Res Ctr GILDRC, Tehran, Iran.
   [Shamshirgaran, Seyed Morteza; Aminisani, Nayyereh; Azimi-Nezhad, Mohsen] Neyshabur Univ Med Sci, Healthy Ageing Res Ctr, Neyshabur, Iran.
   [Abasi, Hamid] Neyshabur Univ Med Sci, Publ Hlth Dept, Neyshabur, Iran.
C3 Iran University of Medical Sciences
RP Hariri, M (corresponding author), Neyshabur Univ Med Sci, Noncommunicable Dis Res Ctr, Janbazan Ave, Neyshabur 1413993186, Iran.
EM hariri.mitra@yahoo.com
RI Doustmohammadian, Azam/HNQ-0687-2023; Shamshirgaran, Seyed/P-9524-2017;
   Gholami, Ali/I-1626-2018
FU Neyshabur University of Medical Sciences [3099]
FX The study was funded by Neyshabur University of Medical Sciences (grant
   number: 3099).
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NR 49
TC 0
Z9 0
U1 0
U2 2
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-4196
EI 1557-8518
J9 METAB SYNDR RELAT D
JI Metab. Syndr. Relat. Disord.
PD OCT 1
PY 2024
VL 22
IS 8
BP 575
EP 582
DI 10.1089/met.2023.0049
EA JUL 2024
PG 8
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA I1R4I
UT WOS:001260937500001
PM 38959090
DA 2025-06-11
ER

PT J
AU Martinelli, I
   Tomassoni, D
   Moruzzi, M
   Roy, P
   Cifani, C
   Amenta, F
   Tayebati, SK
AF Martinelli, Ilenia
   Tomassoni, Daniele
   Moruzzi, Michele
   Roy, Proshanta
   Cifani, Carlo
   Amenta, Francesco
   Tayebati, Seyed Khosrow
TI Cardiovascular Changes Related to Metabolic Syndrome: Evidence in Obese
   Zucker Rats
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE heart; inflammation; obesity; oxidative stress; Zucker rats
ID EPICARDIAL ADIPOSE-TISSUE; NECROSIS-FACTOR-ALPHA; C-REACTIVE PROTEIN;
   OXIDATIVE STRESS; ENDOTHELIAL DYSFUNCTION; MYOCARDIAL-INFARCTION;
   LIPID-PEROXIDATION; ANIMAL-MODEL; INFLAMMATION; HEART
AB Metabolic syndrome (MetS) is a predictor of cardiovascular diseases, commonly associated with oxidative stress and inflammation. However, the pathogenic mechanisms are not yet fully elucidated. The aim of the study is to evaluate the oxidative status and inflammation in the heart of obese Zucker rats (OZRs) and lean Zucker rats (LZRs) at different ages. Morphological and morphometric analyses were performed in the heart. To study the oxidative status, the malondialdehyde (MDA), 4-hydroxynonenal (4-HNE), protein oxidation, and antioxidant enzymes were measured in plasma and heart. To elucidate the inflammatory markers involved, immunohistochemistry and Western blot were performed for cellular adhesion molecules and proinflammatory cytokines. OZRs were characterized by hypertension, hyperlipidemia, hyperglycemia, and insulin resistance. The obesity increased MDA and decreased the activities of superoxide dismutase (SOD) in plasma as well as in the heart, associated with cardiomyocytes hypertrophy. OxyBlot in plasma and in heart showed an increase of oxidativestate proteins in OZRs. Vascular cell adhesion molecule-1, interleukin-6, and tumor necrosis factor-alpha expressions in OZRs were higher than those of LZRs. However, these processes did not induce apoptosis or necrosis of cardiomyocytes. Thus, MetS induces the lipid peroxidation and decreased antioxidant defense that leads to heart tissue changes and coronary inflammation.
C1 [Martinelli, Ilenia; Cifani, Carlo; Amenta, Francesco; Tayebati, Seyed Khosrow] Sch Pharm, Camerino 62032, Italy.
   [Martinelli, Ilenia; Cifani, Carlo; Amenta, Francesco; Tayebati, Seyed Khosrow] Univ Camerino, Camerino 62032, Italy.
   [Tomassoni, Daniele; Roy, Proshanta] Univ Camerino, Sch Biosci & Vet Med, Camerino 62032, Italy.
   [Moruzzi, Michele] Univ Leipzig, Dept Med, Leipzig 04103, Germany.
C3 University of Camerino; University of Camerino; Leipzig University
RP Tayebati, SK (corresponding author), Sch Pharm, Camerino 62032, Italy.; Tayebati, SK (corresponding author), Univ Camerino, Camerino 62032, Italy.
EM ilenia.martinelli@unicam.it; daniele.tomassoni@unicam.it;
   Michele.Moruzzi@medizin.uni-leipzig.de;
   proshanta.roy@studenti.unicam.it; carlo.cifani@unicam.it;
   francesco.amenta@unicam.it; khosrow.tayebati@unicam.it
RI Cifani, Carlo/AAC-5456-2022; Tayebati, Seyed/AGK-8739-2022
OI Roy, Proshanta/0000-0001-6482-6117; Tayebati, Seyed
   Khosrow/0000-0002-7219-6917; MARTINELLI, ILENIA/0000-0002-7702-7784;
   Cifani, Carlo/0000-0001-6180-828X
FU University of Camerino
FX This research was funded by the University of Camerino.
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NR 72
TC 27
Z9 27
U1 0
U2 8
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD MAR
PY 2020
VL 21
IS 6
AR 2035
DI 10.3390/ijms21062035
PG 16
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA LJ0UU
UT WOS:000529890200131
PM 32188150
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Joshi, P
   Joshi, S
   Semwal, DK
   Verma, K
   Dwivedi, J
   Sharma, S
AF Joshi, Priyanka
   Joshi, Sushil
   Semwal, Deepak Kumar
   Verma, Kanika
   Dwivedi, Jaya
   Sharma, Swapnil
TI Role of curcumin in ameliorating hypertension and associated conditions:
   a mechanistic insight
SO MOLECULAR AND CELLULAR BIOCHEMISTRY
LA English
DT Article
DE Curcumin; Turmeric; Anti-hypertensive activity; Oxidative stress; Nitric
   oxide
ID NF-KAPPA-B; NITRIC-OXIDE SYNTHASE; TUMOR-NECROSIS-FACTOR; PULMONARY
   ARTERIAL-HYPERTENSION; MICROVASCULAR ENDOTHELIAL-CELLS;
   ANGIOTENSIN-CONVERTING ENZYME; INDUCED INFLAMMATORY RESPONSE; INDUCED
   VASCULAR DYSFUNCTION; ISCHEMIA-REPERFUSION INJURY; OXIDATIVE STRESS
AB Curcumin, belongs to the curcuminoid family, is a natural phenolic compound, presenting low bioavailability and pleiotropic activity. Since ancient times, curcumin has been in use as food spices and folk remedy to treat cough, cold, cuts and wounds, and skin diseases. Preclinical and clinical studies have indicated that curcumin acts a promising therapeutic agent in the management of a wide array of health issues, viz., hyperlipidemia, metabolic syndrome, anxiety, arthritis, cancer and inflammatory diseases. Owing to its enormous potential, recent research has been focused on the synthesis of curcumin and its analogues for the management of metabolic disorders. In the current scenario, hypertension is considered as a key risk factor due to its involvement in various pathogeneses. Mechanistically, curcumin and its analogues like hexahydrocurcumin, tetrahydrocurcumin, etc. have been reported to elicit anti-hypertensive effect through diverse signalling pathways, viz., pathway mediated by Nrf2-ARE, NF-kB, NO/cGMP/PDE5/MMPs, RAAS/ACE, HAT/HDAC, G0/G1/apoptosis, CYP3A4, UCP2/PARP, VEGF/STAT/AXL/tyrosine kinase and TGF-beta/Smad-mediated pathways. Thus, the present review has been aimed to highlight different molecular pathways involved in the amelioration of hypertension and associated conditions.
C1 [Joshi, Priyanka; Verma, Kanika; Sharma, Swapnil] Banasthali Vidyapith, Dept Pharm, Banasthali 304022, Rajasthan, India.
   [Joshi, Priyanka; Joshi, Sushil] Patanjali Ayurved Ltd, R&D, Patanjali Food & Herbal Pk, Haridwar, Uttarakhand, India.
   [Semwal, Deepak Kumar] Uttarakhand Ayurved Univ, Fac Biomed Sci, Dept Phytochem, Dehra Dun, Uttarakhand, India.
   [Dwivedi, Jaya] Banasthali Vidyapith, Dept Chem, Banasthali, Rajasthan, India.
C3 Banasthali Vidyapith; Banasthali Vidyapith
RP Sharma, S (corresponding author), Banasthali Vidyapith, Dept Pharm, Banasthali 304022, Rajasthan, India.
EM skspharmacology@gmail.com
RI Sharma, Swapnil/AAV-4850-2020; Verma, Kanika/GZA-3489-2022; Semwal,
   Deepak/K-4380-2016
OI Semwal, Deepak/0000-0003-3105-0759; Sharma, Swapnil/0000-0003-2639-7096
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ER

PT J
AU Guleria, A
   Chandna, S
AF Guleria, Ayushi
   Chandna, Sudhir
TI ATM kinase: Much more than a DNA damage responsive protein
SO DNA REPAIR
LA English
DT Review
DE DNA damage; ATM activation; Oxidative stress; Metabolic syndrome;
   Neurodegenration
ID DOUBLE-STRAND BREAKS; GROWTH-FACTOR-I; ATAXIA-TELANGIECTASIA GENE;
   S-PHASE CHECKPOINT; OXIDATIVE STRESS; DEFICIENT MICE;
   IONIZING-RADIATION; SIGNALING PATHWAYS; G(2) CHECKPOINT; MITOCHONDRIAL
   DYSFUNCTION
AB ATM, mutation of which causes Ataxia telangiectasia, has emerged as a cardinal multifunctional protein kinase during past two decades as evidenced by various studies from around the globe. Further to its well established and predominant role in DNA damage response, ATM has also been understood to help in maintaining overall functional integrity of cells; since its mutation, inactivation or deficiency results in a variety of pathological manifestations besides DNA damage. These include oxidative stress, metabolic syndrome, mitochondrial dysfunction as well as neurodegeneration. Recently, high throughput screening using proteomics, metabolomics and transcriptomic studies revealed several proteins which might be acting as substrates of ATM. Studies that can help in identifying effective regulatory controls within the ATM-mediated pathways/mechanisms can help in developing better therapeutics. In fact, more in-depth understanding of ATM-dependent cellular signals could also help in the treatment of variety of other disease conditions since these pathways seem to control many critical cellular functions. In this review, we have attempted to put together a detailed yet lucid picture of the present-day understanding of ATM's role in various pathophysiological conditions involving DNA damage and beyond. (C) 2015 Elsevier B.V. All rights reserved.
C1 [Guleria, Ayushi; Chandna, Sudhir] Inst Nucl Med & Allied Sci, Div Nat Radiat Response Mech, Delhi 110054, India.
C3 Defence Research & Development Organisation (DRDO); Institute of Nuclear
   Medicine & Allied Sciences (INMAS)
RP Chandna, S (corresponding author), Inst Nucl Med & Allied Sci, Div Nat Radiat Response Mech, Delhi 110054, India.
EM sudhirchandna@yahoo.com
RI Chandna, Sudhir/HPD-6329-2023
OI Chandna, Sudhir/0000-0001-8210-5786
FU Defence Research and Development Organization (DRDO) [INM-311-1-5,
   TD-15/INM-313]
FX We wish to thank the Defence Research and Development Organization
   (DRDO) for providing financial support through projects INM-311-1-5 and
   TD-15/INM-313.
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NR 142
TC 115
Z9 127
U1 2
U2 37
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1568-7864
EI 1568-7856
J9 DNA REPAIR
JI DNA Repair
PD MAR
PY 2016
VL 39
BP 1
EP 20
DI 10.1016/j.dnarep.2015.12.009
PG 20
WC Genetics & Heredity; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Genetics & Heredity; Toxicology
GA DH6YJ
UT WOS:000372937700001
PM 26777338
DA 2025-06-11
ER

PT J
AU Sircu, V
   Colesnic, SI
   Covantsev, S
   Corlateanu, O
   Sukhotko, A
   Popovici, C
   Corlateanu, A
AF Sircu, Victoria
   Colesnic, Silvia-Iaroslava
   Covantsev, Serghei
   Corlateanu, Olga
   Sukhotko, Anna
   Popovici, Cristian
   Corlateanu, Alexandru
TI The Burden of Comorbidities in Obstructive Sleep Apnea and the
   Pathophysiologic Mechanisms and Effects of CPAP
SO CLOCKS & SLEEP
LA English
DT Review
DE OSAS; CPAP; diabetes mellitus; hypertension; ischemic heart disease;
   stroke; renal failure
ID POSITIVE AIRWAY PRESSURE; CHRONIC KIDNEY-DISEASE; INSULIN-RESISTANCE;
   OXIDATIVE STRESS; CANCER INCIDENCE; BREAST-CANCER; ASSOCIATION; STROKE;
   RISK; DEPRESSION
AB Micro-arousals and the repeated desaturation of oxyhemoglobin, which are typical in obstructive sleep apnea syndrome (OSAS), have adverse effects on the health of patients, leading to a wide range of complications such as cardiovascular (arterial hypertension, pulmonary hypertension, chronic heart failure, arrhythmias, myocardial infarction), cerebrovascular (strokes), metabolic (insulin resistance, obesity, diabetes mellitus, metabolic syndrome), gastrointestinal (non-alcoholic liver disease), urinary (chronic renal failure), and neuropsychiatric complications as well as a wide range of malignancies. These, in turn, have multilateral effects on familial, occupational, and social life, as well as increasing the risks of road traffic accidents and accidents at the workplace. Awareness, timely screening, and the prevention of complications play important roles in diagnosing and treating comorbid conditions. This review focuses on comorbidities in OSAS and the effect of Continuous Positive Airway Pressure (CPAP) therapy on their prognoses.
C1 [Sircu, Victoria; Colesnic, Silvia-Iaroslava; Popovici, Cristian; Corlateanu, Alexandru] State Univ Med, Dept Internal Med, Div Pneumol & Allergol, Pharm Nicolae Testemitanu, MD-2004 Kishinev, Moldova.
   [Covantsev, Serghei] Botkin Hosp, Dept Clin Res & Dev, Moscow 125284, Russia.
   [Covantsev, Serghei] Botkin Hosp, Dept Emergency Med 76, Moscow 125284, Russia.
   [Corlateanu, Olga] State Univ Med, Dept Internal Med, Pharm Nicolae Testemitanu, MD-2004 Kishinev, Moldova.
   [Sukhotko, Anna] Botkin Hosp, Dept Gen Oncol 71, Moscow 125284, Russia.
RP Corlateanu, A (corresponding author), State Univ Med, Dept Internal Med, Div Pneumol & Allergol, Pharm Nicolae Testemitanu, MD-2004 Kishinev, Moldova.
EM sircu.victoria@yahoo.com; aroslavakolesnik@gmail.com;
   kovantsev.s.d@gmail.com; olga.corlateanu@usmf.md; syxotya26@yandex.ru;
   cris.popovici9@gmail.com; alexandru.corlateanu@usmf.md
RI Corlateanu, Olga/AAC-9828-2020; Corlateanu, Alexandru/ABO-2279-2022;
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OI Serghei, Covantev/0000-0001-7236-5699; Corlateanu,
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NR 107
TC 16
Z9 17
U1 0
U2 6
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2624-5175
J9 CLOCKS SLEEP
JI Clocks Sleep
PD JUN
PY 2023
VL 5
IS 2
BP 333
EP 349
DI 10.3390/clockssleep5020025
PG 17
WC Clinical Neurology; Neurosciences
WE Emerging Sources Citation Index (ESCI)
SC Neurosciences & Neurology
GA K1TO8
UT WOS:001014340600001
PM 37366660
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Lai, YC
   Yew, YW
AF Lai, Yi Chun
   Yew, Yik Weng
TI Psoriasis as an Independent Risk Factor for Cardiovascular Disease: An
   Epidemiologic Analysis Using a National Database
SO JOURNAL OF CUTANEOUS MEDICINE AND SURGERY
LA English
DT Article
DE psoriasis; dermatology; inflammatory dermatoses
ID MYOCARDIAL-INFARCTION; OXIDATIVE STRESS; PLAQUE PSORIASIS; ALCOHOL;
   EVENTS; COHORT; ATHEROSCLEROSIS; METAANALYSIS; MORTALITY; SMOKING
AB Background: Psoriasis is known to be associated with metabolic syndrome, a well-established risk factor for ischemic heart disease and stroke. Emerging evidence indicates that psoriasis is an independent risk factor for cardiovascular disease and stroke.
   Objective: To evaluate whether psoriasis is independently associated with myocardial infarction (MI), ischemic heart disease (MI, angina pectoris, or coronary heart disease), and stroke, we conducted a cross-sectional study using the US National Health and Nutrition Examination Survey (NHANES) database.
   Methods: Data on clinical history of psoriasis, MI, angina pectoris, coronary heart disease, and stroke from the questionnaire as well as laboratory parameters on serum lipid and uric acid levels in the cycle years 2003-2006 and 2009-2012 were analyzed. Multivariate analysis with logistic regression modelling was performed with the aforementioned cardiovascular events or stroke as the dependent variables and with risk factors such as age, gender, ethnic group, current smoking status, alcohol consumption, metabolic syndrome, hyperuricemia, and psoriasis as independent variables.
   Results: There were 520 cases of psoriasis, and 108 of them had metabolic syndrome (20.8%). Well-established cardiovascular risk factors such as age, gender, ethnic group, smoking, alcohol consumption, metabolic syndrome, and hyperuricemia were also found to have significant associations with MI and ischemic heart disease (all P values <.001). Psoriatic patients were at significantly higher risks of developing MI (odds ratio [OR] 2.24; 95% CI: 1.27-3.95; P = .005) and ischemic heart disease (OR 1.90; 95% CI: 1.18-3.05; P = .008), but not stroke (OR 1.01; 95% CI: 0.48-2.16; P = .744), after adjustment was made for major cardiovascular risk factors.
   Conclusion: This study provides epidemiological evidence that psoriasis may be independently associated with the development of MI and ischemic heart disease. Physicians should be cognizant of any underlying cardiovascular risk factors, especially among psoriatic patients with metabolic syndrome, and manage them according to national guidelines.
C1 [Lai, Yi Chun; Yew, Yik Weng] Harvard Univ, TH Chan Sch Publ Hlth, Boston, MA 02115 USA.
   [Yew, Yik Weng] Natl Skin Ctr, 1 Mandalay Rd, Singapore 308205, Singapore.
C3 Harvard University; Harvard T.H. Chan School of Public Health; National
   Skin Centre
RP Yew, YW (corresponding author), Natl Skin Ctr, 1 Mandalay Rd, Singapore 308205, Singapore.
EM yikweng.yew@mail.harvard.edu
RI Weng, Yew/AGQ-4775-2022
OI Yew, Yik Weng/0000-0001-8915-306X
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NR 37
TC 45
Z9 46
U1 0
U2 5
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1203-4754
EI 1615-7109
J9 J CUTAN MED SURG
JI J. Cutan. Med. Surg.
PD JUL-AUG
PY 2016
VL 20
IS 4
BP 327
EP 333
DI 10.1177/1203475415602842
PG 7
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA DP5OA
UT WOS:000378545700008
PM 26316538
DA 2025-06-11
ER

PT J
AU Cho, KI
   Sakuma, I
   Sohn, IS
   Jo, SH
   Koh, KK
AF Cho, Kyoung Im
   Sakuma, Ichiro
   Sohn, Il Suk
   Jo, Sang-Ho
   Koh, Kwang Kon
TI Inflammatory and metabolic mechanisms underlying the calcific aortic
   valve disease
SO ATHEROSCLEROSIS
LA English
DT Review
DE Calcific aortic valve disease; Cardiometabolic risk factors;
   Inflammation; Oxidation; Ossification
ID ANGIOTENSIN-CONVERTING-ENZYME; OXIDATION-SPECIFIC BIOMARKERS;
   LOW-DENSITY-LIPOPROTEIN; VASCULAR CALCIFICATION; OXIDIZED PHOSPHOLIPIDS;
   ELEVATED LIPOPROTEIN(A); LP(A) LIPOPROTEIN; CLINICAL FACTORS; HUMAN
   CORONARY; STENOSIS
AB Although calcific aortic stenosis is a very common disease with major adverse cardiovascular events and healthcare costs, there are no effective medical interventions to delay or halt its progression. Cardiometabolic risk factors, including smoking and male sex, are linked to aortic stenosis. Emerging studies have identified important regulatory roles for immunological and inflammatory responses, including oxidized lipids, various cytokines, and biomineralization. Recent clinical and experimental studies in atherosclerosis and osteoporosis have demonstrated that oxidative stress and oxidized lipids decrease bone formation in the skeletal system while they increase bone formation in the cardiovascular system. Multidisciplinary factors contribute to vascular calcification, including inflammation and metabolic regulation of osteogenesis in the cardiovascular system via similar signaling pathways as bone formation.
   Calcific aortic valve disease (CAVD) is no longer considered a simple passive process of calcium deposition that occurs with advanced age. Biomineralization in CAVD is a complex, regulated process that involves valvular, circulating, bone marrow-derived cells, macrophage heterogeneity and genetic factors along with biochemical and mechanical factors. The current review will discuss the recently discovered important role of inflammation, metabolic risk factors, and molecular and cellular mechanisms that promote CAVD, as well as the link between osteogenic signals in the skeletal and cardiovascular systems. This may inform future therapeutic strategies for CAVD progression.
C1 [Cho, Kyoung Im] Kosin Univ, Gospel Hosp, Dept Cardiol, Busan, South Korea.
   [Sakuma, Ichiro] Hokko Mem Clin, Cardiovasc Med, Sapporo, Hokkaido, Japan.
   [Sakuma, Ichiro] Hlth Sci Univ Hokkaido, Tobetsu, Japan.
   [Sohn, Il Suk] Kyung Hee Univ Hosp Gangdong, Dept Cardiol, Cardiovasc Ctr, Seoul, South Korea.
   [Jo, Sang-Ho] Hanlym Univ Hosp Pyungchon, Dept Cardiol, Pyongchon, South Korea.
   [Koh, Kwang Kon] Gachon Univ, Gil Med Ctr, Dept Cardiovasc Med, Ctr Heart, Incheon, South Korea.
   [Koh, Kwang Kon] Gachon Cardiovasc Res Inst, Incheon, South Korea.
C3 Health Sciences University of Hokkaido; Kyung Hee University; Kyung Hee
   University Hospital; Gachon University
RP Koh, KK (corresponding author), Gachon Univ, Cardiometab Syndrome Unit, Dept Cardiovasc Med, Gil Med Ctr, 774 Beongil 21, Incheon 21565, South Korea.
EM kwangk@gilhospital.com
RI Cho, Young-Seok/J-5670-2012; SOHN, ILSUK/AAI-1097-2020
OI SOHN, IL SUK/0000-0001-8004-5185
FU Korea Health Industry Development Institute (KHIDI) - Ministry of Health
   and Welfare, Korea [HI15C0987, HI14C1135]; Korean Society of
   CardioMetabolic Syndrome
FX This work was supported by a grant from the Korea Health Technology R&D
   Project through the Korea Health Industry Development Institute (KHIDI)
   funded by the Ministry of Health and Welfare, Korea (HI15C0987 &
   HI14C1135) and the Korean Society of CardioMetabolic Syndrome.
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NR 79
TC 96
Z9 104
U1 0
U2 41
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0021-9150
EI 1879-1484
J9 ATHEROSCLEROSIS
JI Atherosclerosis
PD OCT
PY 2018
VL 277
BP 60
EP 65
DI 10.1016/j.atherosclerosis.2018.08.029
PG 6
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA GV2HG
UT WOS:000445908000010
PM 30173080
DA 2025-06-11
ER

PT J
AU Muriel, P
   López-Sánchez, P
   Ramos-Tovar, E
AF Muriel, Pablo
   Lopez-Sanchez, Pedro
   Ramos-Tovar, Erika
TI Fructose and the Liver
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE liver; fructose; uric acid; NLRP3; oxidative stress; inflammation
ID NF-KAPPA-B; FATTY LIVER; OXIDATIVE STRESS; URIC-ACID; DIETARY FRUCTOSE;
   HEPATOCELLULAR-CARCINOMA; LIPID-ACCUMULATION; INSULIN-RESISTANCE;
   METABOLIC SYNDROME; NONALCOHOLIC STEATOHEPATITIS
AB Chronic diseases represent a major challenge in world health. Metabolic syndrome is a constellation of disturbances affecting several organs, and it has been proposed to be a liver-centered condition. Fructose overconsumption may result in insulin resistance, oxidative stress, inflammation, elevated uric acid levels, increased blood pressure, and increased triglyceride concentrations in both the blood and liver. Non-alcoholic fatty liver disease (NAFLD) is a term widely used to describe excessive fatty infiltration in the liver in the absence of alcohol, autoimmune disorders, or viral hepatitis; it is attributed to obesity, high sugar and fat consumption, and sedentarism. If untreated, NAFLD can progress to nonalcoholic steatohepatitis (NASH), characterized by inflammation and mild fibrosis in addition to fat infiltration and, eventually, advanced scar tissue deposition, cirrhosis, and finally liver cancer, which constitutes the culmination of the disease. Notably, fructose is recognized as a major mediator of NAFLD, as a significant correlation between fructose intake and the degree of inflammation and fibrosis has been found in preclinical and clinical studies. Moreover, fructose is a risk factor for liver cancer development. Interestingly, fructose induces a number of proinflammatory, fibrogenic, and oncogenic signaling pathways that explain its deleterious effects in the body, especially in the liver.
C1 [Muriel, Pablo] Cinvestav IPN, Dept Pharmacol, Lab Expt Hepatol, Apartado Postal 14-740, Mexico City 07300, DF, Mexico.
   [Lopez-Sanchez, Pedro; Ramos-Tovar, Erika] Sch Higher Educ Med IPN, Postgrad Studies & Res Sect, Plan San Luis Diaz Miron S-N Casco Santo Tomas, Mexico City 11340, Mexico.
C3 CINVESTAV - Centro de Investigacion y de Estudios Avanzados del
   Instituto Politecnico Nacional
RP Ramos-Tovar, E (corresponding author), Sch Higher Educ Med IPN, Postgrad Studies & Res Sect, Plan San Luis Diaz Miron S-N Casco Santo Tomas, Mexico City 11340, Mexico.
EM pmuriel@cinvestav.mx; pelosa651018@yahoo.com; erikaramost@gmail.com
RI Ramos-Tovar, Erika/HRB-9713-2023; Muriel, Pablo/H-5156-2017; Lopez,
   Pedro/A-1283-2008
OI Muriel, Pablo/0000-0002-2236-6631; Lopez, Pedro/0000-0002-8089-9794;
   Ramos-Tovar, Erika/0000-0002-6616-9760
FU Consejo Nacional de Ciencia y Tecnologia through the Ciencia de Frontera
   funding program [53358]
FX This work was financially supported by Consejo Nacional de Ciencia y
   Tecnologia through the Ciencia de Frontera funding program, grant number
   53358.
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NR 192
TC 86
Z9 91
U1 7
U2 46
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD JUL
PY 2021
VL 22
IS 13
AR 6969
DI 10.3390/ijms22136969
PG 22
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA TF8YA
UT WOS:000671000100001
PM 34203484
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Mali, VR
   Ning, RZ
   Chen, JL
   Yang, XP
   Xu, J
   Palaniyandi, SS
AF Mali, Vishal R.
   Ning, Ruizhuo
   Chen, Jieli
   Yang, Xiao-Ping
   Xu, Jiang
   Palaniyandi, Suresh S.
TI Impairment of aldehyde dehydrogenase-2 by 4-hydroxy-2-nonenal adduct
   formation and cardiomyocyte hypertrophy in mice fed a high-fat diet and
   injected with low-dose streptozotocin
SO EXPERIMENTAL BIOLOGY AND MEDICINE
LA English
DT Article
DE metabolic syndrome; type-2 diabetes mellitus; 4-hydroxy-2-nonenal;
   diabetic cardiac complications; Aldehyde dehydrogenase 2; cardiomyocyte
   hypertrophy
ID ADVANCED GLYCATION; OXIDATIVE STRESS; LIPID-PEROXIDATION;
   MYOCARDIAL-INFARCTION; CONTRACTILE FUNCTION; ALDH2; INHIBITION; RAT;
   DYSFUNCTION; MODEL
AB Reactive aldehydes such as 4-hydroxy-2-nonenal (4HNE) are generated in the myocardium in cardiac disease. 4HNE and other toxic aldehydes form adducts with proteins, leading to cell damage and organ dysfunction. Aldehyde dehydrogenases (ALDHs) metabolize toxic aldehydes such as 4HNE into nontoxic metabolites. Both ALDH levels and activity are reduced in cardiac disease. We examined whether reduced ALDH2 activity contributes to cardiomyocyte hypertrophy in mice fed a high-fat diet and injected with low-dose streptozotocin (STZ). These mice exhibited most of the characteristics of metabolic syndrome/type-2 diabetes mellitus (DM): increased blood glucose levels depicting hyperglycemia (415.2 +/- 18.7 mg/dL vs. 265.2 +/- 7.6 mg/dL; P < 0.05), glucose intolerance with normal plasma insulin levels, suggesting insulin resistance and obesity as evident from increased weight (44 +/- 3.1 vs. 34.50 +/- 1.32 g; P < 0.05) and body fat. Myocardial ALDH2 activity was 60% lower in these mice (0.1 +/- 0.012 vs. 0.04 +/- 0.015 mu mol/min/mg protein; P < 0.05). Myocardial 4HNE levels were also elevated in the hyperglycemic hearts. Co-immunoprecipitation study showed that 4HNE formed adducts on myocardial ALDH2 protein in the mice exhibiting metabolic syndrome/type-2 DM, and they had obvious cardiac hypertrophy compared with controls as evident from increased heart weight (HW), HW to tibial length ratio, left ventricular (LV) mass and cardiomyocyte hypertrophy. Cardiomyocyte hypertrophy was correlated inversely with ALDH2 activity (R-2 = 0.7; P < 0.05). Finally, cardiac dysfunction was observed in mice with metabolic syndrome/type-2 DM. Therefore, we conclude that reduced ALDH2 activity may contribute to cardiac hypertrophy and dysfunction in mice presenting with some of the characteristics of metabolic syndrome/type-2 DM when on a high-fat diet and low-dose STZ injection.
C1 [Mali, Vishal R.; Yang, Xiao-Ping; Xu, Jiang; Palaniyandi, Suresh S.] Henry Ford Hlth Syst, Dept Internal Med, Div Hypertens & Vasc Res, Detroit, MI 48202 USA.
   [Ning, Ruizhuo; Chen, Jieli] Henry Ford Hlth Syst, Dept Neurol, Detroit, MI 48202 USA.
   [Palaniyandi, Suresh S.] Wayne State Univ, Dept Physiol, Detroit, MI 48202 USA.
C3 Henry Ford Health System; Henry Ford Hospital; Henry Ford Health System;
   Henry Ford Hospital; Wayne State University
RP Palaniyandi, SS (corresponding author), Henry Ford Hlth Syst, Dept Internal Med, Div Hypertens & Vasc Res, Detroit, MI 48202 USA.
EM spalani2@hfhs.org
RI ning, ruizhuo/E-6401-2012
FU National Institute on Aging [AG031811, 1R41NS080329]; Henry Ford Health
   System
FX The authors thank Prof. William Beierwaltes for his critical comments.
   This work was supported by the National Institute on Aging Grants
   AG031811 (J.C.), 1R41NS080329 (J.C.), and an internal grant from Henry
   Ford Health System (S.S.P.).
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NR 57
TC 51
Z9 53
U1 0
U2 16
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1535-3702
EI 1535-3699
J9 EXP BIOL MED
JI Exp. Biol. Med.
PD MAY
PY 2014
VL 239
IS 5
BP 610
EP 618
DI 10.1177/1535370213520109
PG 9
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA AG6EM
UT WOS:000335511500011
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Rodríguez-Pérez, C
   García-Villanova, B
   Guerra-Hernández, E
   Verardo, V
AF Rodriguez-Perez, Celia
   Garcia-Villanova, Belen
   Guerra-Hernandez, Eduardo
   Verardo, Vito
TI Grape Seeds Proanthocyanidins: An Overview of In Vivo Bioactivity in
   Animal Models
SO NUTRIENTS
LA English
DT Review
DE grape seed by-products; proanthocyanidins; metabolic syndrome; chronic
   diseases; in vivo animal studies
ID OXIDATIVE STRESS; PHENOLIC-COMPOUNDS; PROCYANIDINS; EXTRACT;
   INFLAMMATION; ANTIOXIDANT; ANTHOCYANINS; BIOSYNTHESIS; ACCUMULATION;
   HYPERTENSION
AB Over the last decade, proanthocyanidins (PACs) are attracting attention not only from the food industry but also from public health organizations due to their health benefits. It is well-known that grapes are a good source of PACs and for that reason, the industry is also focused on grape by-products identification and bioactivity evaluation. Grape seeds extract (GSPE) is a rich source of PACs, mainly composed of monomeric catechin and epicatechin, gallic acid and polymeric and oligomeric proanthocyanidins. Thus, this review encompasses the state-of-art structure and the most recent evidence about the impact of GSPE on chronic diseases, with a focus on oxidative stress, inflammation and metabolic syndrome (MeS)-related disorders such as obesity, diabetes and cardiovascular risk disease in vivo to offer new perspectives in the field that allow further research. Despite the controversial results, is undeniable that PACs from grape seeds are highly antioxidants, thus, the capacity of GSPE to improve oxidative stress might mediate the inflammation process and the progress of MeS-related pathologies. However, further well-design animal studies with standardized dosages and GSPE composition are necessary to shed light into the cause-effect relationship in a more accurate way to later allow a deeper study of the effect of GSPE in humans.
C1 [Rodriguez-Perez, Celia; Garcia-Villanova, Belen; Guerra-Hernandez, Eduardo; Verardo, Vito] Univ Granada, Dept Nutr & Food Sci, Campus Cartuja, E-18071 Granada, Spain.
   [Rodriguez-Perez, Celia; Verardo, Vito] Univ Granada, Biomed Res Ctr, Inst Nutr & Food Technol INYTA Jose Mataix, Ave Conocimiento S-N, E-18071 Granada, Spain.
C3 University of Granada; University of Granada
RP Verardo, V (corresponding author), Univ Granada, Dept Nutr & Food Sci, Campus Cartuja, E-18071 Granada, Spain.; Verardo, V (corresponding author), Univ Granada, Biomed Res Ctr, Inst Nutr & Food Technol INYTA Jose Mataix, Ave Conocimiento S-N, E-18071 Granada, Spain.
EM celiarp@ugr.es; belenv@ugr.es; ejguerra@ugr.es; vitoverardo@ugr.es
RI Rodríguez-Pérez, Celia/R-7378-2019; Guerra-Hernandez,
   Eduardo/K-9562-2014; verardo, vito/W-2878-2017
OI Guerra-Hernandez, Eduardo/0000-0002-2841-7743; Garcia-Villanova Ruiz,
   Belen/0000-0001-5114-300X; Rodriguez-Perez, Celia/0000-0002-7233-6481;
   verardo, vito/0000-0003-0723-5163
FU Spanish Ministry of Economy and Competitiveness (MINECO)
   [RYC-2015-18795]
FX Vito Verardo thanks the Spanish Ministry of Economy and Competitiveness
   (MINECO) for "Ramon y Cajal" contract (RYC-2015-18795).
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NR 84
TC 110
Z9 116
U1 13
U2 104
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD OCT
PY 2019
VL 11
IS 10
AR 2435
DI 10.3390/nu11102435
PG 18
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA JP4HG
UT WOS:000498227300176
PM 31614852
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Nusslock, R
   Miller, GE
AF Nusslock, Robin
   Miller, Gregory E.
TI Early-Life Adversity and Physical and Emotional Health Across the
   Lifespan: A Neuroimmune Network Hypothesis
SO BIOLOGICAL PSYCHIATRY
LA English
DT Review
DE Depression; Heart disease; Inflammation; Maltreatment; Poverty; Stress
ID CHILDHOOD SOCIOECONOMIC CIRCUMSTANCES; CAUSE-SPECIFIC MORTALITY; EARLY
   EXPERIENCE; CARDIOVASCULAR-DISEASE; INFLAMMATORY PROCESSES; DEPRESSIVE
   SYMPTOMS; INSULIN-RESISTANCE; METABOLIC SYNDROME; TELOMERE LENGTH;
   MATERNAL STRESS
AB Children who experience chronic stressors are vulnerable to emotional and physical health problems across the lifespan. This phenomenon raises questions for scientists and clinicians alike. How does adversity get under the skin of the developing child? Through what mechanisms does it confer vulnerability to a heterogeneous set of mental and physical illnesses? And how does it instantiate risk across different life stages, engendering vulnerability to conditions that develop shortly after stressor exposure-like depression-and conditions that manifest decades later, like heart disease? Although answers to these questions have started to emerge, research has typically focused on single diseases or organ systems. To understand the plethora of health problems associated with childhood adversity, we argue that the field needs a second generation of research that recognizes multidirectional transactions among biological systems. To help facilitate this process, we propose a neuroimmune network hypothesis as a heuristic framework for organizing knowledge from disparate literatures and as a springboard for generating integrative research. Drawing on existing data, we argue that early-life adversity amplifies crosstalk between peripheral inflammation and neural circuitries subserving threat-related, reward-related, and executive control-related processes. This crosstalk results in chronic low-grade inflammation, thereby contributing to adiposity, insulin resistance, and other predisease states. In the brain, inflammatory mediators act on cortico-amygdala threat and cortico-basal ganglia reward, circuitries in a manner that predisposes individuals to self-medicating behaviors like smoking, drug use, and consumption of high-fat diets. Acting in concert with inflammation, these behaviors accelerate the pathogenesis of emotional and physical health problems.
C1 [Nusslock, Robin; Miller, Gregory E.] Northwestern Univ, Dept Psychol, 2029 Sheridan Rd,Swift Hall, Evanston, IL 60202 USA.
   [Miller, Gregory E.] Northwestern Univ, Inst Policy Res, Evanston, IL 60202 USA.
C3 Northwestern University; Northwestern University
RP Miller, GE (corresponding author), Northwestern Univ, Dept Psychol, 2029 Sheridan Rd,Swift Hall, Evanston, IL 60202 USA.
EM greg.miller@northwestern.edu
OI Nusslock, Robin/0000-0001-6283-7824; Miller, Gregory/0000-0002-7217-1082
FU National Institute of Mental Health [R01 MH100117]; National Institute
   on Drug Abuse [P30 DA027827]; National Heart, Lung, and Blood Institute
   [R01 HL 122328]
FX Preparation of this article was supported by grants from the National
   Institute of Mental Health (Grant No. R01 MH100117), National Institute
   on Drug Abuse (Grant No. P30 DA027827), and National Heart, Lung, and
   Blood Institute (Grant No. R01 HL 122328).
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NR 149
TC 445
Z9 511
U1 7
U2 246
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0006-3223
EI 1873-2402
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD JUL 1
PY 2016
VL 80
IS 1
BP 23
EP 32
DI 10.1016/j.biopsych.2015.05.017
PG 10
WC Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA DO8TB
UT WOS:000378055600009
PM 26166230
OA Green Accepted
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Auvinen, P
   Mäntyselkä, P
   Koponen, H
   Kautiainen, H
   Korniloff, K
   Ahonen, T
   Vanhala, M
AF Auvinen, Piritta
   Mantyselka, Pekka
   Koponen, Hannu
   Kautiainen, Hannu
   Korniloff, Katariina
   Ahonen, Tiina
   Vanhala, Mauno
TI Prevalence of restless legs symptoms according to depressive symptoms
   and depression type: a cross-sectional study
SO NORDIC JOURNAL OF PSYCHIATRY
LA English
DT Article
DE Restless legs syndrome; depressive disorder; melancholia; depression;
   primary health care
ID WILLIS-EKBOM DISEASE; CLINICAL CHARACTERISTICS; GENERAL-POPULATION;
   METABOLIC SYNDROME; PRIMARY-CARE; RISK-FACTORS; SYNDROME RLS; ADULTS;
   EPIDEMIOLOGY; ASSOCIATION
AB Background: Restless legs syndrome is a sensorimotor disorder and it is associated with several other diseases especially mental illnesses.Aims: To analyze the relationship between the symptoms of restless legs syndrome and the severity of depressive symptoms and the prevalence of restless legs symptoms in depression subtypes.Methods: A cross-sectional study of primary care patients in the Central Finland Hospital District. The prevalence of restless legs symptoms was studied in 706 patients with increased depressive symptoms and 426 controls without a psychiatric diagnosis by using a structured questionnaire. The depressive symptoms were evaluated with the Beck Depression Inventory (BDI) and the psychiatric diagnosis was confirmed by means of a diagnostic interview (Mini-International Neuropsychiatric Interview). The subjects with increased depressive symptoms were divided into three groups (subjects with depressive symptoms without a depression diagnosis, melancholic depression and non-melancholic depression).Results: In the whole study population, the prevalence of restless legs symptoms increased with the severity of depressive symptoms. The prevalence of restless legs symptoms was highest in the melancholic and non-melancholic depressive patients (52 and 46%, respectively) and then in subjects with depressive symptoms without a depression diagnosis (43.4%), but the prevalence was also substantial (24.6%) in subjects without a psychiatric diagnosis.Conclusions: Restless legs symptoms are very common in primary care among subjects with depression, regardless of the depression type. The prevalence of restless legs symptoms increased with increasing severity of depressive symptoms, regardless of the diagnosis. These findings should be considered in clinical evaluation and treatment of patients visiting their physician due to restless legs or depressive symptoms.
C1 [Auvinen, Piritta; Mantyselka, Pekka] Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Gen Practice Unit, POB 1627, FI-70211 Kuopio, Finland.
   [Mantyselka, Pekka] Kuopio Univ Hosp, Primary Hlth Care Unit, Kuopio, Finland.
   [Koponen, Hannu] Univ Helsinki, Dept Psychiat, Helsinki, Finland.
   [Koponen, Hannu] Helsinki Univ Hosp, Helsinki, Finland.
   [Kautiainen, Hannu] Kuopio Univ Hosp, Primary Hlth Care Unit, Kuopio, Finland.
   [Kautiainen, Hannu] Univ Helsinki, Unit Primary Hlth Care, Cent Hosp, Helsinki, Finland.
   [Kautiainen, Hannu] Univ Helsinki, Dept Gen Practice, Helsinki, Finland.
   [Korniloff, Katariina] JAMK Univ Appl Sci, Sch Hlth & Social Studies, Jyvaskyla, Finland.
   [Ahonen, Tiina] Cent Finland Cent Hosp, Primary Hlth Care Unit, Jyvaskyla, Finland.
   [Vanhala, Mauno] Cent Finland Cent Hosp, Jyvaskyla, Finland.
C3 University of Eastern Finland; Kuopio University Hospital; University of
   Eastern Finland; University of Eastern Finland Hospital; University of
   Helsinki; University of Helsinki; Helsinki University Central Hospital;
   Kuopio University Hospital; University of Eastern Finland; University of
   Eastern Finland Hospital; University of Helsinki; Helsinki University
   Central Hospital; University of Helsinki; Jyvaskyla University of
   Applied Sciences; Central Finland Central Hospital; Central Finland
   Central Hospital
RP Auvinen, P (corresponding author), Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Gen Practice Unit, POB 1627, FI-70211 Kuopio, Finland.
EM pirau@student.uef.fi
OI Koponen, Hannu/0000-0002-7368-1869; Korniloff,
   Katariina/0000-0002-0753-1483
FU Central Finland Hospital District; Northern Savo Hospital District;
   Central Finland Health Care District
FX This study was supported by the Central Finland Hospital District, the
   Northern Savo Hospital District and Central Finland Health Care
   District.
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NR 48
TC 12
Z9 12
U1 0
U2 9
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0803-9488
EI 1502-4725
J9 NORD J PSYCHIAT
JI Nord. J. Psychiatr.
PY 2018
VL 72
IS 1
BP 51
EP 56
DI 10.1080/08039488.2017.1385849
PG 6
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA FP7UY
UT WOS:000417846400008
PM 28990833
DA 2025-06-11
ER

PT J
AU Gurudev, S
   Pise, G
   Manohar, N
   Sanagoudar, V
   Rao, K
   Patil, MN
AF Gurudev, Shradha
   Pise, Gajanan
   Manohar, Naveen
   Sanagoudar, Vinitha
   Rao, Kiran
   Patil, Malteshgauda N.
TI Clinico-Epidemiological Study of Papulosquamous Disorders in Childhood
   at a Tertiary Care Hospital in South India
SO INDIAN JOURNAL OF PAEDIATRIC DERMATOLOGY
LA English
DT Article
DE Anthropometry; child; metabolic syndrome; papulosquamous disorders;
   psoriasis
ID LICHEN-STRIATUS; METABOLIC SYNDROME; PSORIASIS; CHILDREN; DERMATOSES;
   FEATURES; DISEASES; INFANTS; PATTERN; PLANUS
AB Introduction: Papulosquamous disorders in children differ from those in adults in terms of presentations, treatments, and prognosis. The aim of this study was to add to the existing data regarding the presentation of pediatric papulosquamous disorders and analyze the metabolic parameters in children with psoriasis. Materials and Methods: This observational study included 83 patients (age, 0-18 years) with clinically diagnosed papulosquamous disorders. Demographic data and detailed clinical history were collected followed by a detailed clinical examination. In children with psoriasis, we assessed the parameters of metabolic health, such as anthropometry and blood chemistry. The outcomes are expressed as percentages and proportions. Results: Papulosquamous disorders constituted 2.3% of all the pediatric dermatoses with a male-to-female ratio of 1.7:1. They were commonly noted in the age group of 7-12 years. Psoriasis vulgaris (26.5%) was the most common disease followed by lichen planus (19.2%), seborrheic dermatitis (16.8%), pityriasis rosea (13.2%), lichen striatus (12%), lichen nitidus (7.2%), pityriasis lichenoides chronica (3.6%), and pityriasis rubra pilaris (1.20%). None of the 22 patients with psoriasis fulfilled the criteria for metabolic syndrome. However, aberrant serum levels included elevated fasting glucose (n = 5, 22.7%), elevated fasting triglycerides (n = 3, 13.6%), and decreased high-density lipoproteins (n = 2, 9.1%). Anthropometric abnormalities were also not noted. Conclusions: Understanding the morphological and epidemiological features of pediatric papulosquamous disorders can aid in early diagnosis, treatment, and counseling the patients and parents, which can alleviate their anxiety and improve the psychological distress.
C1 [Gurudev, Shradha; Pise, Gajanan; Manohar, Naveen; Sanagoudar, Vinitha; Rao, Kiran; Patil, Malteshgauda N.] Belagavi Inst Med Sci, Head Dept Dermatol, Belagavi, India.
RP Pise, G (corresponding author), Belagavi Inst Med Sci, Dept Dermatol, Room 24,Dr. BR Ambedkar Rd, Belagavi 590001, India.
EM gajananpise@gmail.com
RI Manohar, Naveen/IAO-3584-2023
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NR 37
TC 1
Z9 1
U1 0
U2 0
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, Maharashtra, INDIA
SN 2319-7250
EI 2319-7269
J9 INDIAN J PAEDIATR DE
JI Indian J. Paediatr. Dermatol.
PD APR-JUN
PY 2023
VL 24
IS 2
BP 121
EP 128
DI 10.4103/ijpd.ijpd_50_22
PG 8
WC Dermatology; Pediatrics
WE Emerging Sources Citation Index (ESCI)
SC Dermatology; Pediatrics
GA Y6XQ6
UT WOS:001106675400003
OA gold
DA 2025-06-11
ER

PT J
AU Shen, BJ
   Farrell, KA
   Penedo, FJ
   Schneiderman, N
   Orth-Gomer, K
AF Shen, Biing-Jiun
   Farrell, Kristen A.
   Penedo, Frank J.
   Schneiderman, Neil
   Orth-Gomer, Kristina
TI Waist Circumference Moderates the Association Between Marital Stress and
   C-reactive Protein in Middle-Aged Healthy Women
SO ANNALS OF BEHAVIORAL MEDICINE
LA English
DT Article
DE C-reactive protein; Marital stress; Waist circumference; Apolipoprotein;
   Women
ID SOCIOECONOMIC-STATUS; PSYCHOSOCIAL STRESS; METABOLIC SYNDROME;
   APOLIPOPROTEIN-B; OBESE SUBJECTS; INFLAMMATION; RESPONSES; RISK;
   INTERLEUKIN-6; ATHEROSCLEROSIS
AB The relationships among stress, obesity, and inflammation in women remain unclear. This study examined the relationships among marital stress, waist circumference, and C-reactive protein (CRP) in 201 healthy women from the Stockholm Female Coronary Risk Study. We tested whether marital stress was associated with CRP and whether this association was moderated by waist circumference. Hierarchical multiple regression revealed that after adjusting for age, occupation status, fasting glucose, apolipoprotein A1, apolipoprotein B, blood pressure, smoking, and menopausal status, marital stress was not directly associated with CRP. However, waist circumference significantly moderated the association between marital stress and CRP (p=0.012) such that marital stress was significantly associated with higher CRP among women with larger waist circumferences but not in those with smaller waists. More obese women may be particularly vulnerable to the effects of marital stress by manifesting higher inflammation.
C1 [Shen, Biing-Jiun] Univ So Calif, Dept Psychol, Los Angeles, CA 90089 USA.
   [Farrell, Kristen A.; Penedo, Frank J.; Schneiderman, Neil] Univ Miami, Miami, FL USA.
   [Orth-Gomer, Kristina] Karolinska Inst, Stockholm, Sweden.
   [Orth-Gomer, Kristina] Free & Humboldt Univ, Charite Univ Med, Berlin, Germany.
C3 University of Southern California; University of Miami; Karolinska
   Institutet; Berlin Institute of Health; Free University of Berlin;
   Humboldt University of Berlin; Charite Universitatsmedizin Berlin
RP Shen, BJ (corresponding author), Univ So Calif, Dept Psychol, 3620 S McClintock Ave,SGM 501, Los Angeles, CA 90089 USA.
EM bjshen@usc.edu
RI She, Ji/AAW-6150-2021
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NR 44
TC 14
Z9 18
U1 0
U2 6
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0883-6612
EI 1532-4796
J9 ANN BEHAV MED
JI Ann. Behav. Med.
PD DEC
PY 2010
VL 40
IS 3
BP 258
EP 264
DI 10.1007/s12160-010-9211-7
PG 7
WC Psychology, Multidisciplinary
WE Social Science Citation Index (SSCI)
SC Psychology
GA 717JZ
UT WOS:000287041100003
PM 20658213
OA Bronze
DA 2025-06-11
ER

PT J
AU McCrindle, BW
AF McCrindle, Brian W.
TI Cardiovascular Consequences of Childhood Obesity
SO CANADIAN JOURNAL OF CARDIOLOGY
LA English
DT Review
ID TYPE-2 DIABETES-MELLITUS; INTIMA-MEDIA THICKNESS; BODY-MASS INDEX;
   RISK-FACTORS; PHYSICAL-ACTIVITY; BLOOD-PRESSURE; WEIGHT-GAIN; SCIENTIFIC
   STATEMENT; VASCULAR DYSFUNCTION; ENDOTHELIAL FUNCTION
AB Childhood and adolescent overweight and obesity is an important and increasingly prevalent public health problem in Canada and worldwide. High adiposity in youth is indicated in clinical practice by plotting body mass index on appropriate percentile charts normed for age and sex, although waist measures might be a further tool. High adiposity can lead to adiposopathy in youth, with associated increases in inflammation and oxidative stress, changes in adipokines, and endocrinopathy. This is manifest as cardiometabolic risk factors in similar patterns to those in noted in obese adults. Obesity and cardiometabolic risk factors have been shown to be associated with vascular changes indicative of early atherosclerosis, and ventricular hypertrophy, dilation, and dysfunction. These cardiovascular consequences are evident in youth, but childhood obesity is also predictive of similar consequences in adulthood. Childhood obesity and risk factors have been shown to track into adulthood and worsen in most individuals. The result is an exponential acceleration of atherosclerosis, which can be predicted to translate into an epidemic of premature cardiovascular disease and events. A change in paradigm is needed toward preventing and curing atherosclerosis and not just preventing cardiovascular disease. This would necessarily create an imperative for preventing and treating childhood obesity. Urgent attention, policy, and action are needed to avoid the enormous future social and health care costs associated with the cardiovascular consequences of obesity in youth.
C1 [McCrindle, Brian W.] Univ Toronto, Hosp Sick Children, Dept Pediat, Labatt Family Heart Ctr, Toronto, ON M5G 1X8, Canada.
C3 University of Toronto; Hospital for Sick Children (SickKids); Labatt
   Family Heart Centre
RP McCrindle, BW (corresponding author), Hosp Sick Children, 555 Univ Ave, Toronto, ON M5G 1X8, Canada.
EM brian.mccrindle@sickkids.ca
FU CIBC World Markets Endowed Chair in Child Health Research
FX Supported in part by the CIBC World Markets Endowed Chair in Child
   Health Research.
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NR 70
TC 106
Z9 130
U1 0
U2 36
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0828-282X
EI 1916-7075
J9 CAN J CARDIOL
JI Can. J. Cardiol.
PD FEB
PY 2015
VL 31
IS 2
DI 10.1016/j.cjca.2014.08.017
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA CD1FX
UT WOS:000350821300011
PM 25661547
DA 2025-06-11
ER

PT J
AU Khedr, NF
   Zahran, ES
   Ebeid, AM
   Melek, ST
   Werida, RH
AF Khedr, Naglaa F.
   Zahran, Enas S.
   Ebeid, Abla M.
   Melek, Samuel T.
   Werida, Rehab H.
TI Effect of green coffee on miR-133a, miR-155 and inflammatory biomarkers
   in obese individuals
SO DIABETOLOGY & METABOLIC SYNDROME
LA English
DT Article
DE Adiponectin; Green coffee; Metabolic syndrome; miR-133a; miR-155;
   Resistin
ID DENSITY-LIPOPROTEIN CHOLESTEROL; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   GLUCOSE; PLASMA; ALPHA; MIRNA; ACID
AB ObjectivesMetabolic syndrome is a cluster of conditions that increases the risk of atherosclerotic cardiovascular diseases. The current study was a randomized, double blind, placebo-controlled study that aimed to determine the impact of green coffee (GC) in obese patients with metabolic syndrome through analysis of miRNA-155, miRNA-133a and the inflammatory biomarkers such as resistin, TNF-alpha, total sialic acid, homocysteine, high sensitivity C-reactive protein (hs-CRP), and the anti-inflammatory cytokine, adiponectin.MethodsOne hundred-sixty obese patients were randomly supplemented either with GC capsules (800 mg) or placebo daily for six months. Both groups were advised to take a balanced diet. Blood samples were collected at baseline and after six months of supplementation.ResultsGC supplementation for 6 months reduced BMI (p = 0.002), waist circumference (p = 0.038), blood glucose (p = 0.002), HbA1c% (p = 0.000), Insulin (p = 0.000), systolic blood pressure (p = 0.005), diastolic BP (p = 0.001) compared with placebo. GC significantly decreased total cholesterol (TC, p = 0.000), LDL-C (p = 0.001), triglycerides (TG, p = 0.002) and increased HDL-C (p = 0.008) compared with placebo group. In addition, GC significantly (p <= 0.005) reduced total sialic acid, homocysteine, resistin, TNF-alpha, hs-CRP and the oxidative stress marker malondialdehyde (MDA), but increased serum adiponectin (p = 0.000) compared to placebo group. There was a significant reduction in the gene expression of miR-133a (p = 0.000) in GC group as compared with baseline levels and with the control placebo group (p = 0.001) after 6 months.ConclusionGC administration modulated metabolic syndrome by decreasing BMI, high BP, blood glucose, dyslipidemia, miRNA-133a and inflammatory biomarkers that constitute risk factors for cardiovascular diseases.ClinicalTrials.gov registration No. is NCT05688917.ConclusionGC administration modulated metabolic syndrome by decreasing BMI, high BP, blood glucose, dyslipidemia, miRNA-133a and inflammatory biomarkers that constitute risk factors for cardiovascular diseases.ClinicalTrials.gov registration No. is NCT05688917.
C1 [Khedr, Naglaa F.] Tanta Univ, Fac Pharm, Biochem Dept, Med Complex, Al Baher St, Tanta 31527, Egypt.
   [Zahran, Enas S.] Menoufia Univ, Fac Med, Internal Med Dept, Shibin Al Kawm, Egypt.
   [Ebeid, Abla M.] AL Delta Univ, Fac Pharm, Clin Pharm Dept, Gamasa, Egypt.
   [Melek, Samuel T.] Natl Org Drug Control & Res NODCAR, Dept Parasitol & Blood Res, Cairo 12654, Egypt.
   [Werida, Rehab H.] Damanhour Univ, Fac Pharm, Clin Pharm Dept, Damanhour, Egypt.
C3 Egyptian Knowledge Bank (EKB); Tanta University; Egyptian Knowledge Bank
   (EKB); Menofia University; Delta University for Science & Technology;
   National Organization for Drug Control & Research (NODCAR); Egyptian
   Knowledge Bank (EKB); Damanhour University
RP Khedr, NF (corresponding author), Tanta Univ, Fac Pharm, Biochem Dept, Med Complex, Al Baher St, Tanta 31527, Egypt.; Werida, RH (corresponding author), Damanhour Univ, Fac Pharm, Clin Pharm Dept, Damanhour, Egypt.
EM naglaa.khedr@pharm.tanta.edu.eg; rehabwrieda@pharm.dmu.edu.eg
RI Werida, Rehab/AAU-2278-2021
OI khedr, naglaa/0000-0003-4539-8940
FU Tanta University; Faculty of Pharmacy, Tanta University
FX The authors thank medical staff members of the Internal Medicine
   Department, Faculty of Medicine, Menoufia University, Egypt, for helping
   in the recruitment of participants. Authors also thank the Faculty of
   Pharmacy, Tanta University and the Faculty of Pharmacy, at Damanhour and
   Delta University for supporting the research.
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NR 64
TC 0
Z9 0
U1 1
U2 1
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1758-5996
J9 DIABETOL METAB SYNDR
JI Diabetol. Metab. Syndr.
PD OCT 28
PY 2024
VL 16
IS 1
AR 256
DI 10.1186/s13098-024-01478-7
PG 16
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA K5R4N
UT WOS:001344442100001
PM 39468643
OA Green Accepted, gold
DA 2025-06-11
ER

PT J
AU Martins, AC
   Ferrer, B
   Tinkov, AA
   Caito, S
   Deza-Ponzio, R
   Skalny, AV
   Bowman, AB
   Aschner, M
AF Martins, Airton C.
   Ferrer, Beatriz
   Tinkov, Alexey A.
   Caito, Samuel
   Deza-Ponzio, Romina
   Skalny, Anatoly V.
   Bowman, Aaron B.
   Aschner, Michael
TI Association between Heavy Metals, Metalloids and Metabolic Syndrome: New
   Insights and Approaches
SO TOXICS
LA English
DT Review
DE arsenic; cadmium; diabetes; hypertension; lead; mercury; obesity
ID WHITE ADIPOSE-TISSUE; ARSENIC EXPOSURE; CADMIUM EXPOSURE; OXIDATIVE
   STRESS; NATIONAL-HEALTH; URINARY CADMIUM; METHYL MERCURY; BODY-WEIGHT;
   INSULIN-SECRETION; ENDOTHELIAL-CELLS
AB Metabolic syndrome (MetS) is an important public health issue that affects millions of people around the world and is growing to pandemic-like proportions. This syndrome is defined by the World Health Organization (WHO) as a pathologic condition characterized by abdominal obesity, insulin resistance, hypertension, and hyperlipidemia. Moreover, the etiology of MetS is multifactorial, involving many environmental factors, including toxicant exposures. Several studies have associated MetS with heavy metals exposure, which is the focus of this review. Environmental and/or occupational exposure to heavy metals are a major risk, contributing to the development of chronic diseases. Of particular note, toxic metals such as mercury, lead, and cadmium may contribute to the development of MetS by altering oxidative stress, IL-6 signaling, apoptosis, altered lipoprotein metabolism, fluid shear stress and atherosclerosis, and other mechanisms. In this review, we discuss the known and potential roles of heavy metals in MetS etiology as well as potential targeted pathways that are associated with MetS. Furthermore, we describe how new approaches involving proteomic and transcriptome analysis, as well as bioinformatic tools, may help bring about an understanding of the involvement of heavy metals and metalloids in MetS.
C1 [Martins, Airton C.; Ferrer, Beatriz; Deza-Ponzio, Romina; Aschner, Michael] Albert Einstein Coll Med, Dept Mol Pharmacol, New York, NY 10461 USA.
   [Tinkov, Alexey A.; Skalny, Anatoly V.] Yaroslavl State Univ, Lab Ecobiomonitoring & Qual Control, Yaroslavl 150003, Russia.
   [Tinkov, Alexey A.; Skalny, Anatoly V.] Sechenov Univ, IM Sechenov First Moscow State Med Univ, Moscow 119435, Russia.
   [Caito, Samuel] Husson Univ, Sch Pharm, Bangor, ME 04401 USA.
   [Bowman, Aaron B.] Purdue Univ, Sch Hlth Sci, W Lafayette, IN 47907 USA.
C3 Yeshiva University; Yaroslavl State University; Sechenov First Moscow
   State Medical University; Husson University; Purdue University System;
   Purdue University
RP Aschner, M (corresponding author), Albert Einstein Coll Med, Dept Mol Pharmacol, New York, NY 10461 USA.
EM airton.dacunhamartinsjunior@einsteinmed.edu; tinkov.a.a@gmail.com;
   bowma117@purdue.edu; michael.aschner@einsteinmed.edu
RI Skalny, Anatoly/J-3953-2019; Tinkov, Alexey/H-5842-2016; Aschner,
   Michael/ACO-6461-2022; C. Martins, Airton/I-8463-2017
OI C. Martins, Airton/0000-0002-2157-5984; aschner,
   michael/0000-0002-2619-1656; Bowman, Aaron/0000-0001-8728-3346; Deza
   Ponzio, Romina/0000-0002-4591-168X
FU Russian Ministry of Science and Higher Education [FENZ-2023-0004];
   National Institute of Environmental Health (NIEHS) [R01ES10563,
   R01ES07331]
FX A.A.T. and A.V.S. were supported by the Russian Ministry of Science and
   Higher Education, Project No. FENZ-2023-0004. MA and ABB were supported
   in part by grants from the National Institute of Environmental Health
   (NIEHS) R01ES10563 and R01ES07331.
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   Zuo Z, 2019, SCI TOTAL ENVIRON, V668, P310, DOI 10.1016/j.scitotenv.2019.03.008
NR 258
TC 15
Z9 15
U1 2
U2 16
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2305-6304
J9 TOXICS
JI Toxics
PD AUG
PY 2023
VL 11
IS 8
AR 670
DI 10.3390/toxics11080670
PG 29
WC Environmental Sciences; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Toxicology
GA Q4FI6
UT WOS:001057088400001
PM 37624175
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Wu, XY
   Liang, DJ
   Sun, JF
   Lin, YY
   Wu, SJ
AF Wu, Xiaoyun
   Liang, Dongjie
   Sun, Junfang
   Lin, Yanyan
   Wu, Shengjie
TI Association Between Sex-Specific Serum Gamma-Glutamyltransferase and
   Incidence of Hypertension in a Chinese Population Without Metabolic
   Syndrome: A Prospective Observational Study
SO FRONTIERS IN CARDIOVASCULAR MEDICINE
LA English
DT Article
DE gamma-glutamyltransferase; hypertension; metabolic syndrome;
   sex-specific; Chinese population
ID FATTY LIVER-DISEASE; OXIDATIVE STRESS; CARDIOVASCULAR-DISEASE;
   RISK-FACTORS; GLUTAMYLTRANSFERASE; INFLAMMATION; PREDICTOR; ENZYMES;
   CANCER; LEVEL
AB Background: Higher serum gamma-glutamyltransferase (GGT) is associated with high risk of hypertension. We aimed to examine the association between sex-specific serum GGT levels and incident of hypertension in a Chinese population without metabolic syndrome.
   Methods: Participants who were free of hypertension and metabolic syndrome from the First Affiliated Hospital of Wenzhou Medical University between 2009 and 2014 were included. Participants were grouped into sex-specific quartiles of GGT levels (Q1-Q4) defined as: <= 19, 20-26, 27-38, and >= 39 U/L for male; <= 12, 13-15, 16-19, and >= 20 U/L for female. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for incidence of hypertension according to sex-specific quartiles of GGT levels. Kaplan-Meier analysis and interaction analysis were conducted.
   Results: Among 38,806 participants included (average age 36.0 years, 54.0% men), 4,505 of them developed hypertension. In the overall study population, using Q1 as the reference group, participants in Q2, Q3, and Q4 showed a higher risk of developing hypertension, with HRs (95% CIs) of 1.126 (1.029-1.232), 1.187 (1.083-1.302), and 1.300 (1.182-1.431), respectively (P < 0.001), after adjusting for known confounders. Sex-specific analysis showed that the adjusted HRs for participants in Q4 (reference: Q1) were greater in females [1.321 (1.100-1.586, P < 0.001)] than in males [1.268 (1.133-1.420, P < 0.001)] (P for interaction = 0.047). Moreover, interaction analysis showed that this association was consistently observed when the participants were stratified by age, body mass index, and fatty liver status.
   Conclusion: Among Chinese adults without metabolic syndrome, serum GGT level was positively associated with incidence of hypertension, and the association was stronger in females than in males.
C1 [Wu, Xiaoyun] Wenzhou Med Univ, Dept Rehabil, Affiliated Hosp 1, Wenzhou, Peoples R China.
   [Liang, Dongjie; Sun, Junfang; Wu, Shengjie] Wenzhou Med Univ, Dept Cardiol, Affiliated Hosp 1, Wenzhou, Peoples R China.
   [Liang, Dongjie; Wu, Shengjie] Key Lab Cardiovasc Dis Wenzhou, Wenzhou, Peoples R China.
   [Lin, Yanyan] Wenzhou Med Univ, Dept Neurol, Affiliated Hosp 1, Wenzhou, Peoples R China.
C3 Wenzhou Medical University; Wenzhou Medical University; Wenzhou Medical
   University
RP Wu, SJ (corresponding author), Wenzhou Med Univ, Dept Cardiol, Affiliated Hosp 1, Wenzhou, Peoples R China.; Wu, SJ (corresponding author), Key Lab Cardiovasc Dis Wenzhou, Wenzhou, Peoples R China.
EM wusj120@163.com
RI liang, dongjie/ABD-0926-2022
CR Ali SS, 2016, NUTR METAB, V13, DOI 10.1186/s12986-016-0097-7
   Bonnet F, 2017, J HYPERTENS, V35, P493, DOI 10.1097/HJH.0000000000001204
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NR 34
TC 4
Z9 6
U1 0
U2 4
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2297-055X
J9 FRONT CARDIOVASC MED
JI Front. Cardiovasc. Med.
PD APR 16
PY 2021
VL 8
AR 644044
DI 10.3389/fcvm.2021.644044
PG 9
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA RU9CC
UT WOS:000645436600001
PM 33937358
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Shivappa, N
   Hébert, JR
   Veronese, N
   Caruso, MG
   Notarnicola, M
   Maggi, S
   Stubbs, B
   Firth, J
   Fornaro, M
   Solmi, M
AF Shivappa, Nitin
   Hebert, James R.
   Veronese, Nicola
   Caruso, Maria Gabriella
   Notarnicola, Maria
   Maggi, Stefania
   Stubbs, Brendon
   Firth, Joseph
   Fornaro, Michele
   Solmi, Marco
TI The relationship between the dietary inflammatory index
   (DII<SUP>®</SUP>) and incident depressive symptoms: A longitudinal
   cohort study
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Depression; Health behavior; Neuroimmunology; Old age
ID METABOLIC SYNDROME; MAJOR DEPRESSION; RISK-FACTOR; METAANALYSIS;
   ASSOCIATION; PREVALENCE; DISEASE; OBESITY; CANCER; WOMEN
AB Background: Diet is a common source of inflammation, and inflammation is associated with depression. We examined the association between the dietary inflammatory index (DII (R)), a validated measure of inflammatory potential of the diet, and risk of depression in a cohort of older North American adults.
   Methods: This longitudinal study, with a follow-up of 8 years, included 3648 participants (1577 males, 2071 females; mean age: 60.6 years) with/at risk of knee osteoarthritis. DII (R) scores were calculated using the validated Block Brief 2000 Food-Frequency Questionnaire. Center for Epidemiological Studies Depression-20 scale was used to define depressive symptoms. The relationship between baseline DII (R) score and incident depression was assessed through Cox's regression analysis, adjusted for potential confounders, and reported as hazard ratios (HRs).
   Results: In total, 837 individuals (310 men and 527 women) developed incident depressive symptoms over the course of 8 years. Participants in the most pro-inflammatory group (quartile 4) had approximately 24% higher risk of developing depressive symptoms compared to subjects with the most anti-inflammatory diet (HR: 1.24; 95% CI: 1.01-1.53; p = 0.04).
   Conclusion: These results suggest that a pro-inflammatory diet may be associated with higher incidence of depressive symptoms in a cohort of older Americans. Transitioning to a more anti-inflammatory diet may reduce depression risk.
C1 [Shivappa, Nitin; Hebert, James R.] Univ South Carolina, Arnold Sch Publ Hlth, Canc Prevent & Control Program, Columbia, SC 29208 USA.
   [Shivappa, Nitin; Hebert, James R.] Univ South Carolina, Arnold Sch Publ Hlth, Dept Epidemiol & Biostat, Columbia, SC 29208 USA.
   [Shivappa, Nitin; Hebert, James R.] Connecting Hlth Innovat LLC, Columbia, SC 29201 USA.
   [Veronese, Nicola; Maggi, Stefania] CNR, Neurosci Inst, Aging Branch, Padua, Italy.
   [Veronese, Nicola; Caruso, Maria Gabriella; Notarnicola, Maria] IRCCS S de Bellis, Natl Inst Gastroenterol, Res Hosp, Lab Nutr Biochem, Bari, Italy.
   [Veronese, Nicola; Caruso, Maria Gabriella] IRCCS S de Bellis, Natl Inst Gastroenterol, Res Hosp, Ambulatory Clin Nutr, Bari, Italy.
   [Stubbs, Brendon] South London & Maudsley NHS Fdn Trust, London, England.
   [Stubbs, Brendon] Kings Coll London, Inst Psychiat Psychol & Neurosci, London, England.
   [Stubbs, Brendon] Anglia Ruskin Univ, Fac Hlth Social Care & Educ, Chelmsford, England.
   [Firth, Joseph] Univ Western Sydney, NICM Hlth Res Inst, Sydney, NSW, Australia.
   [Fornaro, Michele] Univ Naples Federico II, Dept Psychiat, Naples, Italy.
   [Solmi, Marco] Univ Padua, Psychiat Unit, Dept Neurosci, Via Giustiniani, I-35128 Padua 2, Italy.
C3 University of South Carolina System; University of South Carolina
   Columbia; University of South Carolina System; University of South
   Carolina Columbia; Connecting Health Innovations LLC; Consiglio
   Nazionale delle Ricerche (CNR); IRCCS Saverio de Bellis; IRCCS Saverio
   de Bellis; South London & Maudsley NHS Trust; University of London;
   King's College London; Anglia Ruskin University; Western Sydney
   University; University of Naples Federico II; University of Padua
RP Solmi, M (corresponding author), Univ Padua, Psychiat Unit, Dept Neurosci, Via Giustiniani, I-35128 Padua 2, Italy.
EM marco.solmi83@gmail.com
RI Stubbs, Brendon/X-1904-2018; solmi, marco/K-3906-2018; Shivappa,
   Nitin/X-2215-2018; Firth, Joseph/JOZ-1679-2023; Hebert,
   James/IUO-5628-2023; Veronese, Nicola/K-4343-2018; Stubbs,
   Brendon/C-5696-2015
OI Veronese, Nicola/0000-0002-9328-289X; Fornaro,
   Michele/0000-0002-9647-0853; Caruso, Maria
   Gabriella/0000-0003-4518-6307; Stubbs, Brendon/0000-0001-7387-3791;
   solmi, marco/0000-0003-4877-7233
FU National Institutes of Health, a branch of the Department of Health and
   Human Services [N01-AR-2-2258, N01-AR-2-2259, N01-AR-2-2260,
   N01-AR-2-2261, N01-AR-2-2262]; Merck Research Laboratories; Novartis
   Pharmaceuticals Corporation; GlaxoSmithKline; Pfizer, Inc.; United
   States National Institute for Diabetes, Digestive and Kidney Diseases
   [R44DK103377]
FX The OAI is a public-private partnership comprised of five contracts
   (N01-AR-2-2258; N01-AR-2-2259; N01-AR-2-2260; N01-AR-2-2261;
   N01-AR-2-2262) funded by the National Institutes of Health, a branch of
   the Department of Health and Human Services, and conducted by the OAI
   Study Investigators. Private funding partners include Merck Research
   Laboratories; Novartis Pharmaceuticals Corporation, GlaxoSmithKline; and
   Pfizer, Inc. Private sector funding for the OAI is managed by the
   Foundation for the http://dx.doi.org/10.13039/100000002. This manuscript
   was prepared using an OAI public use data set and does not necessarily
   reflect the opinions or views of the OAI investigators, the NIH, or the
   private funding partners. NS and JRH were supported by the United States
   National Institute for Diabetes, Digestive and Kidney Diseases (grant
   no. R44DK103377). Sponsor's role: the sponsors had no role in the
   design, methods, subject recruitment, data collection, analysis or
   preparation of this paper.
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NR 58
TC 55
Z9 57
U1 6
U2 26
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD AUG 1
PY 2018
VL 235
BP 39
EP 44
DI 10.1016/j.jad.2018.04.014
PG 6
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA GG4SQ
UT WOS:000432686900006
PM 29649709
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Radhakrishnan, R
   Kaser, M
   Guloksuz, S
AF Radhakrishnan, Rajiv
   Kaser, Muzaffer
   Guloksuz, Sinan
TI The Link Between the Immune System, Environment, and Psychosis
SO SCHIZOPHRENIA BULLETIN
LA English
DT Article
DE psychosis; schizophrenia; inflammation; immune system; cytokine;
   environment; cannabis; social defeat; childhood trauma
ID PERIPHERAL INFLAMMATION; SCHIZOPHRENIA; NEUROINFLAMMATION;
   PSYCHOPATHOLOGY; ASSOCIATION; DEPRESSION; DISORDERS; STRESS; RISK; PET
AB The last decade has witnessed a burgeoning interest in studies exploring the link between psychosis spectrum disorders (PSD) and altered immune function. While epidemiological and clinical studies point to evidence for increased peripheral inflammatory markers in PSD, it is not clear whether peripheral inflammation correlates with central inflammation in the brain. Furthermore, these studies are confounded by multiple methodological and disorder-related factors such as antipsychotic medications, smoking, obesity, and metabolic syndrome, all of which independently contribute to altered inflammation. Clinical and animal studies provide encouraging evidence that inflammatory processes can define-trans-diagnostic neuropsychiatric domains such as-positive/negative valence, affective dysregulation, and cognitive impairment. In this commentary, we speculate on whether inflammation-mediated pathways may serve as a final-common pathway for environmental risk factors of early-childhood adversity, adolescent cannabis use, social exclusion, and on the possible mechanisms mediating the pathophysiology of PSD. We propose an integrative framework and suggest future research strategies that may help disentangle the link between immune dysfunction and PSD.
C1 [Radhakrishnan, Rajiv; Guloksuz, Sinan] Yale Univ, Sch Med, Dept Psychiat, New Haven, CT 06520 USA.
   [Kaser, Muzaffer] Univ Cambridge, Dept Psychiat, Cambridge, England.
   [Kaser, Muzaffer] Cambridgeshire & Peterborough NHS Fdn Trust, Cambridge, England.
   [Guloksuz, Sinan] Maastricht Univ, Med Ctr, Dept Psychiat & Psychol, POB 616, NL-6200 MD Maastricht, Netherlands.
C3 Yale University; University of Cambridge; Maastricht University
RP Guloksuz, S (corresponding author), Yale Univ, Sch Med, Dept Psychiat, New Haven, CT 06520 USA.; Guloksuz, S (corresponding author), Maastricht Univ, Med Ctr, Dept Psychiat & Psychol, POB 616, NL-6200 MD Maastricht, Netherlands.
EM sinan.guloksuz@maastrichtuniversity.nl
RI Kaser, Muzaffer/N-7799-2013; Guloksuz, Sinan/AAH-1076-2019;
   Radhakrishnan, Rajiv/ADP-4678-2022
OI Radhakrishnan, Rajiv/0000-0002-8220-655X; Kaser,
   Muzaffer/0000-0002-1106-1613; Guloksuz, Sinan/0000-0002-6626-1874
FU European Community [HEALTH-F2-2009-241909]; Dana Foundation David
   Mahoney Program; Thomas P. Detre Award in Translational Neuroscience
   Research
FX S.G. would like to acknowledge the European Community's Seventh
   Framework Program under grant agreement no. HEALTH-F2-2009-241909
   (Project EU-GEI). R.R. is supported by the Dana Foundation David Mahoney
   Program and Thomas P. Detre Award in Translational Neuroscience
   Research.
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NR 37
TC 65
Z9 66
U1 3
U2 26
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0586-7614
EI 1745-1701
J9 SCHIZOPHRENIA BULL
JI Schizophr. Bull.
PD JUL
PY 2017
VL 43
IS 4
BP 693
EP 697
DI 10.1093/schbul/sbx057
PG 5
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA EX6HU
UT WOS:000403344200006
PM 28969353
OA Green Published
DA 2025-06-11
ER

PT J
AU Zangara, MT
   Johnston, I
   Johnson, EE
   McDonald, C
AF Zangara, Megan T.
   Johnston, Isabel
   Johnson, Erin E.
   McDonald, Christine
TI Mediators of Metabolism: An Unconventional Role for NOD1 and NOD2
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE NLR; metabolism; ER stress; mitochondria; hypoxia; high fat diet;
   metabolic syndrome; insulin resistance; obesity; diabetes
ID INNATE IMMUNE-RESPONSES; INSULIN-RESISTANCE; ER STRESS; ADIPOSE-TISSUE;
   INDUCED INFLAMMATION; ACTIVATION; EXPRESSION; OBESITY; DYSBIOSIS;
   GLUCOSE
AB In addition to their classical roles as bacterial sensors, NOD1 and NOD2 have been implicated as mediators of metabolic disease. Increased expression of NOD1 and/or NOD2 has been reported in a range of human metabolic diseases, including obesity, diabetes, non-alcoholic fatty liver disease, and metabolic syndrome. Although NOD1 and NOD2 share intracellular signaling pathway components, they are differentially upregulated on a cellular level and have opposing impacts on metabolic disease development in mouse models. These NOD-like receptors may directly mediate signaling downstream of cell stressors, such as endoplasmic reticulum stress and calcium influx, or in response to metabolic signals, such as fatty acids and glucose. Other studies suggest that stimulation of NOD1 or NOD2 by their bacterial ligands can result in inflammation, altered insulin responses, increased reactive oxygen signaling, and mitochondrial dysfunction. The activating stimuli for NOD1 and NOD2 in the context of metabolic disease are controversial and may be a combination of both metabolic and circulating bacterial ligands. In this review, we will summarize the current knowledge of how NOD1 and NOD2 may mediate metabolism in health and disease, as well as highlight areas of future investigation.
C1 [Zangara, Megan T.; Johnston, Isabel; Johnson, Erin E.; McDonald, Christine] Cleveland Clin, Lerner Res Inst, Dept Inflammat & Immun, Cleveland, OH 44195 USA.
   [Zangara, Megan T.; McDonald, Christine] Case Western Reserve Univ, Cleveland Clin, Dept Mol Med, Lerner Coll Med, Cleveland, OH 44106 USA.
   [Johnson, Erin E.] John Carroll Univ, Dept Biol, University Hts, OH 44118 USA.
C3 Cleveland Clinic Foundation; University System of Ohio; Case Western
   Reserve University; Cleveland Clinic Foundation; University System of
   Ohio; John Carroll University
RP McDonald, C (corresponding author), Cleveland Clin, Lerner Res Inst, Dept Inflammat & Immun, Cleveland, OH 44195 USA.; McDonald, C (corresponding author), Case Western Reserve Univ, Cleveland Clin, Dept Mol Med, Lerner Coll Med, Cleveland, OH 44106 USA.
EM zangarm@ccf.org; johnsti@ccf.org; exjohnson@jcu.edu; mcdonac2@ccf.org
RI Zangara, Megan/JGD-4769-2023
OI Zangara, Megan/0000-0002-0884-9936; McDonald,
   Christine/0000-0002-6745-9487; Johnston, Isabel/0000-0002-2770-2841
FU Office of the Assistant Secretary of Defense for Health Affairs through
   the Congressionally Directed Medical Research Programs Peer Reviewed
   Medical Research Program [W81XWH1910488 (PR181846)]
FX This research was supported by the Office of the Assistant Secretary of
   Defense for Health Affairs through the Congressionally Directed Medical
   Research Programs Peer Reviewed Medical Research Program under Award No.
   W81XWH1910488 (PR181846) and philanthropic support from Cure for IBD and
   the McDonald Family Trust. Opinions, interpretations, conclusions, and
   recommendations are those of the authors and are not necessarily
   endorsed by the funders.
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NR 60
TC 24
Z9 26
U1 2
U2 11
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD FEB
PY 2021
VL 22
IS 3
AR 1156
DI 10.3390/ijms22031156
PG 14
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA QD1PC
UT WOS:000615298400001
PM 33503814
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Liu, PJ
   Liao, EC
   Guo, CH
   Lu, MP
   Liao, H
   Liu, KL
AF Liu, P. J.
   Liao, E. C.
   Guo, C. H.
   Lu, M. P.
   Liao, H.
   Liu, K. L.
TI PHYTOCHEMICAL AND NUTRITIONAL SUPPLEMENT THERAPY FOR PATIENTS WITH
   SEVERE OBSTRUCTIVE SLEEP APNEA
SO CURRENT TOPICS IN NUTRACEUTICAL RESEARCH
LA English
DT Article
DE Inflammation; Nutritional Intervention; Oxidative Stress; Sleep Apnea;
   Supplement Therapy
ID OXIDATIVE STRESS; ENDOTHELIAL FUNCTION; PROTEIN; OBESITY; DISEASE; DIET;
   RISK
AB Obstructive sleep apnea is an increasingly common disease highly associated with metabolic syndrome. Lifestyle nzodifi cations and weight control are recommended for obese patients with obstructive sleep apnea. We designed a single-arm pre-post clinical trial assessing 29 male participants aged 39.17 +/- 7.30 years with severe obstructive sleep apnea. They received a 12 week intervention consisting of a specific pbytochemical-containing medical functional food fish oil vitamin C, and coenzyme Q10. Anthropometric measurements, polysomnography, Epworth Sleepiness Scale scores, health-related quality of life assessment, and multiple biochemical parameters were assessed. After the intervention, participants showed significant decreases in body weight; body mass index; neck, waist, and hip circumferences; waist-to-hip ratio; and body fat percentage. The apnea-hypopnea index decreased from 53.43 +/- 18.82 to 34.38 +/- 24.41 (P < 0.001). Oxygen desaturation index and Epworth Sleepiness Scale scores also decreased significantly. Participants experienced reductions in systolic and diastolic blood pressure (P = 0.004), and significantly fewer in metabolic syndrome variables (P = 0.001). Our results suggest that specific phytochemical-containing medical food and nutritional supplement intervention can lower anthroponzetric and metabolic variables, oxidative stress, inflammatory status, apnea-hypopnea index, and oxygen desaturation index, and improve quality of life in obese subjects with severe obstructive sleep apnea.
C1 [Liu, P. J.] Cheng Ching Gen Hosp, Chung Kang Branch, Dept Otolaryngol, 966 Sec 4,Taiwan Blvd, Taichung 40764, Taiwan.
   [Liu, P. J.] Cheng Ching Gen Hosp, Chung Kang Branch, Sleep Ctr, 966 Sec 4,Taiwan Blvd, Taichung 40764, Taiwan.
   [Liao, E. C.] Mackay Med Coll, Dept Med, 46 Sec 3,Zhongzheng Rd, New Taipei 25245, Taiwan.
   [Guo, C. H.] Hung Kuang Univ, Inst Biomed Nutr, 1018 Sec 6,Taiwan Blvd, New Taipei 43302, Taiwan.
   [Lu, M. P.] Hung Kuang Univ, Dept Nutr, 5F 21,Ln 266,Dexing E Rd, Taipei 11148, Taiwan.
   [Liao, H.] Taipei Med Univ, Sch Nutr & Hlth Sci, 4F,17,Ln 113,Hsia Men St, Taipei 10082, Taiwan.
   [Liu, K. L.] Chung Shan Med Univ, Chung Shan Med Univ Hosp, Dept Nutr, Sch Nutr, 110 Sec 1,Jianguo N Rd, Taichung 40201, Taiwan.
C3 Mackay Medical College; Taipei Medical University; Chung Shan Medical
   University; Chung Shan Medical University Hospital
RP Liu, KL (corresponding author), Chung Shan Med Univ, Chung Shan Med Univ Hosp, Dept Nutr, Sch Nutr, 110 Sec 1,Jianguo N Rd, Taichung 40201, Taiwan.
EM kaililiu@csmu.edu.tw
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NR 27
TC 0
Z9 0
U1 0
U2 5
PU NEW CENTURY HEALTH PUBLISHERS, LLC
PI COPPELL
PA PO BOX 175, COPPELL, TX 75019 USA
SN 1540-7535
J9 CURR TOP NUTRACEUT R
JI Curr. Top. Nutraceutical Res.
PY 2017
VL 15
IS 2
BP 87
EP 95
PG 9
WC Nutrition & Dietetics; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics; Pharmacology & Pharmacy
GA FH8DM
UT WOS:000411422000006
DA 2025-06-11
ER

PT J
AU Benharrat, LI
   Senouci, A
   Benhabib, W
   Mekki, K
AF Benharrat, Latifa Imen
   Senouci, Azzeddine
   Benhabib, Wassila
   Mekki, Khedidja
TI Omega 3 Supplementation Improves Inflammation and Antioxidant Defense in
   Women with Polycystic Ovary Syndrome
SO CURRENT NUTRITION & FOOD SCIENCE
LA English
DT Article
DE Oxidative status; Inflammation; Metabolic syndrome; Omega 3;
   Dyslipidemia; Hyperglycemia; Polycystic ovary syndrome
ID OXIDATIVE STRESS; OMEGA-3-FATTY-ACIDS
AB Background: Polycystic ovary syndrome (PCOS) is the most common female endocrine disorder and is accompanied by metabolic syndrome (MS), a risk factor for cardiovascular disorders.
   Objective: To evaluate the effect of Omega 3 on the improvement of some metabolic parameters.
   Materials/methods: Sixty women (29 +/- 6 years) with PCOS and MS were randomized into two groups: 30 received supplementation with omega-3 (Doppelherz, Activ, Germany), 3g/day (1g per capsule and 3 capsules/day), (180mg Eicosapentaenoic Acid (EPA)/120mg Docosahexaenoic Acid DHA per day), and 30 were used as controls. Blood samples were drawn at baseline (T0), 3 weeks (T1) and 6 weeks (T2) after start of treatment. We analysed glycemia, lipid profile, markers of inflammation and oxidative stress.
   Results: In omega-3 group compared to control, a reduction (p<0.05) in glucose levels was noted at T1 and T2. C-reactive protein (CRP) concentrations were decreased (-25%) at T2. Oxidative stress remain unchanged, but the activity of superoxide dismutase increased as well as the concentrations of Catalase and thiols at T1 and T2 (p<0.001).
   Conclusion: Omega 3 supplementation improves hyperglycemia, inflammation, and antioxidant defense in PCOS women with MS, and may lead to decreased cardiovascular complications.
C1 [Benharrat, Latifa Imen; Senouci, Azzeddine; Mekki, Khedidja] Univ Oran1, Fac Nat & Life Sci, Lab Clin & Metab Nutr, Oran 31100, Algeria.
   [Benhabib, Wassila] Univ Hosp Oran, Dept Epidemiol, Oran 31037, Algeria.
RP Mekki, K (corresponding author), Univ Oran1, Fac Nat & Life Sci, Lab Clin & Metab Nutr, Themat Agcy Res Hlth Sci, Oran, Algeria.
EM khmekki@hotmail.com
RI SENOUCI, Azzeddine/LKK-0511-2024; MEKKI, Khedidja/K-3832-2016
OI MEKKI, Khedidja/0000-0001-8783-3088; Senouci,
   Azzeddine/0000-0003-4684-6602
FU Thematic Agency of Research in Health Sciences; Oran, Algeria
FX This work was supported by the Thematic Agency of Research in Health
   Sciences. Oran, Algeria
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U1 0
U2 6
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1573-4013
EI 2212-3881
J9 CURR NUTR FOOD SCI
JI Curr. Nutr. Food Sci.
PY 2022
VL 18
IS 2
BP 193
EP 200
DI 10.2174/1573401317666211104121725
PG 8
WC Nutrition & Dietetics
WE Emerging Sources Citation Index (ESCI)
SC Nutrition & Dietetics
GA 1Z0HR
UT WOS:000808515900009
DA 2025-06-11
ER

PT J
AU Camacho, A
   Larsen, B
   McClelland, RL
   Morgan, C
   Criqui, MH
   Cushman, M
   Allison, MA
AF Camacho, Alvaro
   Larsen, Britta
   McClelland, Robyn L.
   Morgan, Cindy
   Criqui, Michael H.
   Cushman, Mary
   Allison, Matthew A.
TI Association of subsyndromal and depressive symptoms with inflammatory
   markers among different ethnic groups: The multi-ethnic study of
   atherosclerosis (MESA)
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Subsyndromal depression; Inflammation; Cardiovascular disease;
   Depressive states
ID CORONARY-HEART-DISEASE; SELF-RATED HEALTH; METABOLIC SYNDROME; COGNITIVE
   DECLINE; ANXIETY; WOMEN; RISK; MEDICATIONS; MIGRATION; HISTORY
AB Objective: Depressive symptoms are associated with inflammation yet the association between inflammation and different levels of depression remains unclear. Therefore, we studied the association of subsyndromal and depressive symptoms with inflammatory markers in a large multi ethnic cohort.
   Methods: C-reactive protein (CRP) (n=6269), interleukin-6 (IL-6) (n=6135) and tumor necrosis factor alpha (TNF-alpha) (n=1830) were measured in selected participants from the multi ethnic study of atherosclerosis (MESA). Subsyndromal depressive symptoms were defined as a CES-D value from 8 to 15, depressive symptoms as a CES-D >= 16 and normal as a CES-D <= 7. Depressive states (subsyndromal and depressed) were entered into multivariable linear regression models incrementally adjusting for demographic, behavioral, biologic and comorbidities.
   Results: Among 6289 participants not taking antidepressants and free from CVD, the mean age was 622, while 52% were women, 36.4% were Caucasian, 28.9% African-American, 22.3% Hispanics and 12.4% Chinese-American. Of the total, 24.2% had subsyndromal depression and 11.8% had depressive symptoms. Compared to the non depressed group and after controlling for demographics, there was no association between both subsyndromal and depressive symptoms with log CRP (beta = 0.01, p=0.80 and beta=-0.05, p=0.25 respectively), log IL-6 (beta=0.01, p=0.71 and beta=-0.04, p=0.07 respectively) and log TNF-alpha (beta=-0.03, p=0.29 and beta=0.06, p=0.18 respectively). Moreover, fully adjusted models showed no significant associations for log IL-6 and log TNF-alpha and the different depressive categories. However, with Full adjustment, we found a significant inverse association between depressive symptoms and In CRP (alpha=-0.10, p=0.01) that was not present for subsyndromal depression (beta=-0.05, p=0.11).
   Conclusion: Among participants not taking anti-depressants, subsyndromal depression is not associated with inflammation. However, depressive symptoms measured by CES-D >= 16 are associated with a lower inflammation (CRP). (C) 2014 Elsevier B.V. All rights reserved
C1 [Camacho, Alvaro; Larsen, Britta; Morgan, Cindy; Criqui, Michael H.; Allison, Matthew A.] Univ Calif San Diego, Dept Family & Prevent Med, San Diego, CA 92103 USA.
   [McClelland, Robyn L.] Univ Washington, Dept Biostat, Seattle, WA 98195 USA.
   [Cushman, Mary] Univ Vermont, Dept Med, Burlington, VT USA.
C3 University of California System; University of California San Diego;
   University of Washington; University of Washington Seattle; University
   of Vermont
RP Camacho, A (corresponding author), 2417,Marshall Ave Suite 1, Imperial, CA 92251 USA.
EM acamacho@ucsd.edu
RI Criqui, Michael/AFT-6067-2022; Cushman, Mary/K-1157-2019
OI Cushman, Mary/0000-0002-7871-6143; Allison, Matthew/0000-0003-0777-8272
FU NHLBI NIH HHS [T32HL079891, N01-HC-95159, N01 HC095169, N01 HC095159,
   T32 HL079891] Funding Source: Medline
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NR 51
TC 17
Z9 19
U1 0
U2 11
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD AUG 1
PY 2014
VL 164
BP 165
EP 170
DI 10.1016/j.jad.2014.04.018
PG 6
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA AH9BX
UT WOS:000336436000026
PM 24856570
OA Green Accepted, Green Published
DA 2025-06-11
ER

PT J
AU Tyagi, A
   Cohen, M
AF Tyagi, Anupama
   Cohen, Marc
TI Yoga and Hypertension: A Systematic Review
SO ALTERNATIVE THERAPIES IN HEALTH AND MEDICINE
LA English
DT Article
ID GUIDED BREATHING EXERCISES; AMBULATORY BLOOD-PRESSURE; TYPE-2
   DIABETES-MELLITUS; HEART-RATE-VARIABILITY; QUALITY-OF-LIFE;
   RISK-FACTORS; HATHA-YOGA; NONPHARMACOLOGIC TREATMENT;
   CARDIOVASCULAR-DISEASE; TREATING HYPERTENSION
AB Lifestyle modification is a cornerstone of hypertension (HPT) treatment, yet most recommendations currently focus on diet and exercise and do not consider stress reduction strategies. Yoga is a spiritual path that may reduce blood pressure (BP) through reducing stress, increasing parasympathetic activation, and altering baroreceptor sensitivity; however, despite reviews on yoga and cardiovascular disease, diabetes, metabolic syndrome, and anxiety that suggest yoga may reduce BP, no comprehensive review has yet focused on yoga and HPT. A systematic review of all published studies on yoga and HPT was performed revealing 39 cohort studies, 30 nonrandomized, controlled trials (NRCTs), 48 randomized, controlled trials (RCTs), and 3 case reports with durations ranging from 1 wk to 4 y and involving a total of 6693 subjects. Most studies reported that yoga effectively reduced BP in both normotensive and hypertensive populations. These studies suggest that yoga is an effective adjunct therapy for HPT and worthy of inclusion in clinical guidelines, yet the great heterogeneity of yoga practices and the variable quality of the research makes it difficult to recommend any specific yoga practice for HPT. Future research needs to focus on high quality clinical trials along with studies on the mechanisms of action of different yoga practices.
C1 [Tyagi, Anupama] RMIT Univ, Sch Hlth Sci, Bundoora, Vic, Australia.
   [Cohen, Marc] RMIT Univ, Sch Hlth Sci, Melbourne, Vic, Australia.
C3 Royal Melbourne Institute of Technology (RMIT); Royal Melbourne
   Institute of Technology (RMIT)
RP Cohen, M (corresponding author), RMIT Univ, Sch Hlth Sci, Melbourne, Vic, Australia.
EM marc.cohen@rmit.edu.au
RI Cohen, Marc/GWV-0933-2022
OI Cohen, Marc/0000-0002-5876-6565
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NR 183
TC 41
Z9 50
U1 0
U2 24
PU InnoVision Professional Media
PI Eagan
PA 3470 Washington Drive Suite 102, Eagan, MN 55122, UNITED STATES
SN 1078-6791
J9 ALTERN THER HEALTH M
JI Altern. Ther. Health Med.
PD MAR-APR
PY 2014
VL 20
IS 2
BP 32
EP 59
PG 28
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA AZ2YD
UT WOS:000348094300005
PM 24657958
DA 2025-06-11
ER

PT J
AU Bjoernsdottir, S
   Ulfsdottir, H
   Gudmundsson, EF
   Sveinsdottir, K
   Isberg, AP
   Dobies, B
   Magnusdottir, GEA
   Gunnarsdottir, T
   Karlsdottir, T
   Bjornsdottir, G
   Sigurdsson, S
   Oddsson, S
   Gudnason, V
AF Bjoernsdottir, Sigridur
   Ulfsdottir, Hildigunnur
   Gudmundsson, Elias Freyr
   Sveinsdottir, Kolbrun
   Isberg, Ari Pall
   Dobies, Bartosz
   Magnusdottir, Gudlaug Erla Akerlie
   Gunnarsdottir, Thrudur
   Karlsdottir, Tekla
   Bjornsdottir, Gudlaug
   Sigurdsson, Sigurdur
   Oddsson, Saemundur
   Gudnason, Vilmundur
TI User Engagement, Acceptability, and Clinical Markers in a Digital Health
   Program for Nonalcoholic Fatty Liver Disease: Prospective, Single-Arm
   Feasibility Study
SO JMIR CARDIO
LA English
DT Article
DE digital health program; nonalcoholic fatty liver disease; NAFLD;
   cardiometabolic health; digital therapeutics; liver; chronic; hepatic;
   cardiometabolic; cardiovascular; cardiology; weight; acceptability;
   digital health; metabolic syndrome; diabetic; diabetes; diabetics; type
   2; BMI; lifestyle; exercise; physical activity; coaching; diet; dietary;
   nutrition; nutritional; patient education; coach; feasibility; fat; body
   composition
ID WEIGHT-LOSS; LIFE-STYLE; ASSOCIATION; STEATOSIS; NAFLD; RISK
AB Background: Nonalcoholic fatty liver disease (NAFLD) has become the most common chronic liver disease in the world. Common comorbidities are central obesity, type 2 diabetes mellitus, dyslipidemia, and metabolic syndrome. Cardiovascular disease is the most common cause of death among people with NAFLD, and lifestyle changes can improve health outcomes. Objective: This study aims to explore the acceptability of a digital health program in terms of engagement, retention, and user satisfaction in addition to exploring changes in clinical outcomes, such as weight, cardiometabolic risk factors, and health-related quality of life. Methods: We conducted a prospective, open-label, single-arm, 12-week study including 38 individuals with either a BMI >30, metabolic syndrome, or type 2 diabetes mellitus and NAFLD screened by FibroScan. An NAFLD-specific digital health program focused on disease education, lowering carbohydrates in the diet, food logging, increasing activity level, reducing stress, and healthy lifestyle coaching was offered to participants. The coach provided weekly feedback on food logs and other in-app activities and opportunities for participants to ask questions. The coaching was active throughout the 12-week intervention period. The primary outcome was feasibility and acceptability of the 12-week program, assessed through patient engagement, retention, and satisfaction with the program. Secondary outcomes included changes in weight, liver fat, body composition, and other cardiometabolic clinical parameters at baseline and 12 weeks. Results: In total, 38 individuals were included in the study (median age 59.5, IQR 46.3-68.8 years; n=23, 61% female). Overall, 34 (89%) participants completed the program and 29 (76%) were active during the 12-week program period. The median satisfaction score was 6.3 (IQR 5.8-6.7) of 7. Mean weight loss was 3.5 (SD 3.7) kg (P<.001) or 3.2% (SD 3.4%), with a 2.2 (SD 2.7) kg reduction in fat mass (P<.001). Relative liver fat reduction was 19.4% (SD 23.9%). Systolic blood pressure was reduced by 6.0 (SD 13.5) mmHg (P=.009). The median reduction was 0.14 (IQR 0-0.47) mmol/L for triglyceride levels (P=.003), 3.2 (IQR 0.0-5.4) mu U/ml for serum insulin (s-insulin) levels (P=.003), and 0.5 (IQR -0.7 to 3.8) mmol/mol for hemoglobin A(1c) (HbA(1c)) levels (P=.03). Participants who were highly engaged (ie, who used the app at least 5 days per week) had greater weight loss and liver fat reduction. Conclusions: The 12-week-long digital health program was feasible for individuals with NAFLD, receiving high user engagement, retention, and satisfaction. Improved liver-specific and cardiometabolic health was observed, and more engaged participants showed greater improvements. This digital health program could provide a new tool to improve health outcomes in people with NAFLD.
C1 [Bjoernsdottir, Sigridur] Karolinska Inst, Dept Endocrinol Metab & Diabet, Solnavagen 1, S-17177 Stockholm, Sweden.
   [Ulfsdottir, Hildigunnur; Gudmundsson, Elias Freyr; Sveinsdottir, Kolbrun; Isberg, Ari Pall; Dobies, Bartosz; Magnusdottir, Gudlaug Erla Akerlie; Gunnarsdottir, Thrudur; Oddsson, Saemundur] Sidekick Hlth, Kopavogur, Iceland.
   [Bjornsdottir, Gudlaug; Sigurdsson, Sigurdur; Gudnason, Vilmundur] Iceland Heart Assoc, Kopavogur, Iceland.
   [Bjornsdottir, Gudlaug; Sigurdsson, Sigurdur; Gudnason, Vilmundur] Univ Iceland, Fac Med, Sch Hlth Sci, Reykjavik, Iceland.
C3 Karolinska Institutet; Icelandic Heart Association; University of
   Iceland
RP Bjoernsdottir, S (corresponding author), Karolinska Inst, Dept Endocrinol Metab & Diabet, Solnavagen 1, S-17177 Stockholm, Sweden.
EM sigridur.bjornsdottir@ki.se
RI Gudnason, Vilmundur/AAE-7126-2019
OI Bjornsdottir, Sigridur/0000-0002-3320-5972; Ulfsdottir,
   Hildigunnur/0009-0004-0301-7710; , Bartosz Dobies/0009-0000-8851-3692;
   Isberg, Ari Pall/0000-0002-7957-6285; Gudmundsson, Elias
   Freyr/0000-0002-7661-4872; Akerlie Magnusdottir, Gudlaug
   Erla/0009-0002-8441-0017; Sveinsdottir, Kolbrun/0009-0001-3148-5210
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NR 49
TC 0
Z9 0
U1 1
U2 4
PU JMIR PUBLICATIONS, INC
PI TORONTO
PA 130 QUEENS QUAY East, Unit 1100, TORONTO, ON M5A 0P6, CANADA
EI 2561-1011
J9 JMIR CARDIO
JI JMIR Cardio
PY 2024
VL 8
AR e52576
DI 10.2196/52576
PG 15
WC Cardiac & Cardiovascular Systems
WE Emerging Sources Citation Index (ESCI)
SC Cardiovascular System & Cardiology
GA W3Y4Y
UT WOS:001417972500001
PM 38152892
OA Green Submitted, gold, Green Published
DA 2025-06-11
ER

PT J
AU Pirmoradi, MR
   Asgharzadeh, A
   Birashk, B
   Gharraee, B
   Salehian, R
   Ostadrahimi, AR
AF Pirmoradi, Mohammad Reza
   Asgharzadeh, Ali
   Birashk, Behrooz
   Gharraee, Banafsheh
   Salehian, Razieh
   Ostadrahimi, Ali Reza
TI Acceptance, Mindfulness, and Compassionate-Based Intervention in
   Overweight and Obese Women and its Effect on Metabolic Syndrome
   Components: A Randomized Controlled Trial
SO CRESCENT JOURNAL OF MEDICAL AND BIOLOGICAL SCIENCES
LA English
DT Article
DE Overweight; Obesity; Acceptance; Mindfulness; Self-compassion;
   Randomized controlled trial
ID QUALITY-OF-LIFE; BODY-IMAGE; SYMPTOMS; ANXIETY; STYLES
AB Objectives: This study aimed to examine the efficacy of acceptance, mindfulness, and compassion (Kg-free) on obese and overweight women diagnosed with metabolic syndrome components. Materials and Methods: In this randomized controlled trial, 52 obese and overweight women with body mass index (BMI) >= 25 were evaluated in two intervention and control groups, The intervention was implemented weekly. Triglyceride (TG), high-density lipoprotein (HDL), fasting blood sugar (FBS), blood pressure (BP), BMI, and waistline measurements thyroid tests were assessed measured as the main outcome, and life-quality and sexual function improvement as its secondary outcome in pre, post and follow-up phase. Results: The study results indicated that the acceptance, mindfulness, and compassion (Kg-free) protocol was effective on the BMI, waistline, TG level, BP (systolic and diastolic index), quality of life, and sexual function in women with overweight and obesity, but fasting BP and HDL level did not significant (d=0.001-0.50; significant at the 0.001 level). Conclusions: The present trial was carried out aiming to examine the efficacy of group intervention based on acceptance, mindfulness, and compassion on obese and overweighed women and its effect on the components of metabolic syndrome, including the waistline, BMI, BP, FBS, TG, HDL, the quality of life, and the sexual function. Our results showed that group intervention based on acceptance, mindfulness, and compassion could reduce the BMI of the individuals in the intervention group compared to the control group. Moreover, the present study provided further evidence that this intervention bears an essential part in the psychological interventions for individuals struggling with overweight and obesity.
C1 [Pirmoradi, Mohammad Reza; Asgharzadeh, Ali; Birashk, Behrooz; Gharraee, Banafsheh] Iran Univ Med Sci, Tehran Inst Psychiat, Sch Behav Sci & Mental Hlth, Tehran, Iran.
   [Salehian, Razieh] Iran Univ Med Sci, Rasoul E Akram Hosp, Sch Med, Dept Psychiat, Tehran, Iran.
   [Ostadrahimi, Ali Reza] Tabriz Univ Med Sci, Nutr Res Ctr, Tabriz, Iran.
C3 Iran University of Medical Sciences; Iran University of Medical
   Sciences; Tabriz University of Medical Science
RP Asgharzadeh, A (corresponding author), Iran Univ Med Sci, Tehran Inst Psychiat, Sch Behav Sci & Mental Hlth, Tehran, Iran.
EM ali.asgharzadeh72@gmail.com
RI Gharraee, Banafsheh/O-2535-2018; Salehian, Razieh/B-2043-2019
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NR 42
TC 1
Z9 1
U1 3
U2 3
PU ARAS PART MEDICAL INT PRESS
PI TABRIZ
PA NO 1, S SHAREATI ST, 5138815941, TABRIZ, 00000, IRAN
SN 2148-9696
J9 CRESCENT J MED BIOL
JI Crescent J. Med. Biol. Sci.
PD OCT
PY 2024
VL 11
IS 4
BP 195
EP 206
DI 10.34172/cjmb.2023.25
PG 12
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA K8M5R
UT WOS:001346382400006
DA 2025-06-11
ER

PT J
AU Straub, RH
AF Straub, Rainer H.
TI Insulin resistance, selfish brain, and selfish immune system: an
   evolutionarily positively selected program used in chronic inflammatory
   diseases
SO ARTHRITIS RESEARCH & THERAPY
LA English
DT Review
ID BETA-CELL FUNCTION; OBESITY-RELATED HYPERTENSION; ACTIVE
   RHEUMATOID-ARTHRITIS; NECROSIS-FACTOR-ALPHA; METABOLIC SYNDROME;
   GLUCOSE-METABOLISM; MENTAL STRESS; JOB STRAIN; INFLIXIMAB TREATMENT;
   DIABETES-MELLITUS
AB Insulin resistance (IR) is a general phenomenon of many physiological states, disease states, and diseases. IR has been described in diabetes mellitus, obesity, infection, sepsis, trauma, painful states such as postoperative pain and migraine, schizophrenia, major depression, chronic mental stress, and others. In arthritis, abnormalities of glucose homeostasis were described in 1920; and in 1950 combined glucose and insulin tests unmistakably demonstrated IR. The phenomenon is now described in rheumatoid arthritis, systemic lupus erythematosus, ankylosing spondylitis, polymyalgia rheumatica, and others. In chronic inflammatory diseases, cytokine-neutralizing strategies normalize insulin sensitivity. This paper delineates that IR is either based on inflammatory factors (activation of the immune/repair system) or on the brain (mental activation via stress axes). Due to the selfishness of the immune system and the selfishness of the brain, both can induce IR independent of each other. Consequently, the immune system can block the brain (for example, by sickness behavior)and the brain can block the immune system (for example, stress-induced immune system alterations). Based on considerations of evolutionary medicine, it is discussed that obesity per se is not a disease. Obesity-related IR depends on provoking factors from either the immune system or the brain. Chronic inflammation and/or stress axis activation are thus needed for obesity-related IR. Due to redundant pathways in stimulating IR, a simple one factor-neutralizing strategy might help in chronic inflammatory diseases (inflammation is the key), but not in obesity-related IR. The new considerations towards IR are interrelated to the published theories of IR (thrifty genotype, thrifty phenotype, and others).
C1 Univ Hosp, Dept Internal Med, Div Rheumatol, Lab Expt Rheumatol & Neuroendocrine Immunol, D-93042 Regensburg, Germany.
C3 University of Regensburg
RP Straub, RH (corresponding author), Univ Hosp, Dept Internal Med, Div Rheumatol, Lab Expt Rheumatol & Neuroendocrine Immunol, D-93042 Regensburg, Germany.
EM rainer.straub@ukr.de
OI Straub, Rainer H/0000-0003-1165-4555
FU Horizon Pharma Inc.
FX This supplement was proposed, developed and commissioned by Arthritis
   Research & Therapy and was funded by an educational grant from Horizon
   Pharma Inc. All published articles were independently prepared by the
   authors and have undergone peer review in accordance with the journal's
   standard policies and processes. Horizon Pharma Inc had no input into
   the topics covered or the articles themselves. The Supplement Editor was
   appointed by the journal and declares that they have no competing
   interests.
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NR 144
TC 56
Z9 57
U1 1
U2 21
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1478-6354
EI 1478-6362
J9 ARTHRITIS RES THER
JI Arthritis Res. Ther.
PY 2014
VL 16
SU 2
AR S4
DI 10.1186/ar4688
PG 15
WC Rheumatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Rheumatology
GA AX9JC
UT WOS:000347218300005
PM 25608958
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Kim, KM
   Han, SM
   Min, IK
   Heo, K
   Kim, WJ
   Chu, MK
AF Kim, Kyung Min
   Han, Seung Min
   Min, In Kyung
   Heo, Kyoung
   Kim, Won-Joo
   Chu, Min Kyung
TI Weekend catch-up sleep and depression: results from a nationally
   representative sample in Korea
SO SLEEP MEDICINE
LA English
DT Article
DE Depressive disorder; Sleep; Epidemiology; Chronobiology phenomena
ID SOCIAL JETLAG; METABOLIC SYNDROME; ASSOCIATION; HEALTH; POPULATION;
   EPIDEMIOLOGY; CHRONOTYPE; PREVALENCE; NUTRITION; DURATION
AB Background: There is limited information on the association between weekend catch-up sleep (CUS), which has beneficial effects on health, and depression. This study aimed to investigate the association between CUS and depression in adults. Methods: We used the data of the Seventh Korea National Health and Nutrition Examination Survey, 2016. Depression was defined as Patient Health Questionnaire-9 score >10. We categorized CUS duration as <0, 0 < to 1, 1 < to 2, and >2 h. Results: Of 5550 eligible participants, 3286 (54.9%), 1033 (19.5%), 723 (14.7%) and 508 (10.9%) had CUS duration <0, 0 < to 1,1 < to 2, and >2 h, respectively; of these, the prevalence of depression was 7.0%, 4.2%, 2.9%, and 6.0%, respectively. Multivariable regression analyses including covariates revealed that individuals with CUS duration 1 < to 2 h had a significantly decreased risk of depression compared to individuals with CUS duration <0 h (odds ratio [OR] = 0.517, 95% CI = 0.309-0.865). Individuals with CUS duration 0 < to 1 h (OR = 0.731, 95% CI = 0.505-1.060) and >2 h (OR = 1.164, 95% CI = 0.718-1.886) showed no significantly different risk of depression. Conclusions: The risk of depression in individuals with CUS duration 1 < to 2 h was lower than for those with CUS duration <0 h. This finding provides a better understanding on the association between CUS and depression; and can be a basis for better management of depression. (c) 2021 Elsevier B.V. All rights reserved.
C1 [Kim, Kyung Min] Yonsei Univ, Yongin Severance Hosp, Dept Neurol, Coll Med, Yongin, South Korea.
   [Han, Seung Min; Heo, Kyoung; Chu, Min Kyung] Yonsei Univ, Severance Hosp, Dept Neurol, Coll Med, 50-1 Yonsei Ro, Seoul 03722, South Korea.
   [Min, In Kyung] Yonsei Univ, Dept Biomed Syst Informat, Biostat Collaborat Unit, Coll Med, Seoul, South Korea.
   [Kim, Won-Joo] Yonsei Univ, Gangnam Severance Hosp, Dept Neurol, Coll Med, Seoul, South Korea.
C3 Yonsei University; Yonsei University Health System; Yonsei University;
   Yonsei University Health System; Yonsei University; Yonsei University
   Health System; Yonsei University; Yonsei University Health System
RP Chu, MK (corresponding author), Yonsei Univ, Severance Hosp, Dept Neurol, Coll Med, 50-1 Yonsei Ro, Seoul 03722, South Korea.
EM chumk@yonsei.ac.kr
RI Kim, Kyung/N-6095-2017; Kim, Kyung/F-3470-2010; Hahn, Seung
   min/MBH-8374-2025
OI Chu, Min Kyung/0000-0001-6221-1346; Kim, Won-Joo/0000-0002-5850-010X;
   Kim, Kyung Min/0000-0002-0261-1687
FU National Research Foundation of Korea (NRF) - Korean government (MSIT)
   [2019R1F1A1052841]
FX This work was supported by the National Research Foundation of Korea
   (NRF) grant funded by the Korean government (MSIT) (2019R1F1A1052841).
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GA UX7NZ
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PM 34520972
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   Lackner, N
   Birner, A
   Platzer, M
   Fellendorf, FT
   Queissner, R
   Filic, K
   Reininghaus, B
   Wallner-Liebmann, SJ
   Mangge, H
   Zelzer, S
   Fuchs, D
   Kapfhammer, HP
   McIntyre, RS
   Reininghaus, EZ
AF Bengesser, Susanne A.
   Lackner, Nina
   Birner, Armin
   Platzer, Martina
   Fellendorf, Frederike T.
   Queissner, Robert
   Filic, Kristijan
   Reininghaus, Bernd
   Wallner-Liebmann, Sandra J.
   Mangge, Harald
   Zelzer, Sieglinde
   Fuchs, Dietmar
   Kapfhammer, Hans-Peter
   McIntyre, Roger S.
   Reininghaus, Eva Z.
TI Mood Stabilizers, Oxidative Stress and Antioxidative Defense in Euthymia
   of Bipolar Disorder
SO CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
LA English
DT Article
DE Oxidative stress; antioxidative parameters; malondialdehyde; carbonyl
   proteins; glutathione S-transferase
ID GLUTATHIONE-S-TRANSFERASE; ANIMAL-MODEL; LIPID-PEROXIDATION;
   NITRIC-OXIDE; SUPEROXIDE-DISMUTASE; METABOLIC SYNDROME; AUTOIMMUNE
   RESPONSES; MAJOR DEPRESSION; DNA-DAMAGE; LITHIUM
AB Background: Hitherto literature indicates that mood stabilizers exert variable effects on oxidative and antioxidative systems, which are involved in the pathogenesis of Bipolar Disorder. Herein we primarily sought to characterize markers of peripheral oxidative stress during euthymia in adults with Bipolar Disorder under current intake of different mood stabilizers (lithium, anticonvulsants and atypical antipsychotics/AAPs).
   Methods: Peripheral oxidative stress parameters (TBARS/Thiobarbituric acid-reactive-substances, MDA/malondial-dehyde and carbonyl proteins) and antioxidative markers (SOD/Cu/Zn superoxide dismutase, GST/glutathione S-transferase and TAC/total antioxidative capacity) were measured in serum of 115 euthymic bipolar individuals (50 females, 65 males; HAMD<11 and YMRS<8). Differences in (anti) oxidative markers between bipolar participants treated with different mood stabilizing medication were tested with MANCOVAS and ANCOVAS with SPSS.21.
   Results: Bipolar individuals taking lithium had significantly lower oxidative parameters than test persons without lithium (multivariate effect for MDA and TBARS: F(2/182)= 3.956, p= 0.021; univariate effect for MDA: F(2/182)= 7.880, p= 0.006, Partial eta 2=0.041). Subjects with AAPs had significantly higher MDA and TBARS levels compared to participants without AAPs (multivariate effect F(2/182)= 3.122, p= 0.046, Partial eta 2=0.033). Patients taking anticonvulsants had significantly lower GST levels than patients without antiepileptic medication (F(1/165)= 4.501, p= 0.035, Partial eta 2= 0.027).
   Conclusion: Lithium taking participants had the lowest MDA and TBARS levels, while AAP taking test persons had high oxidative stress markers. The observed effects on oxidative markers may provide a mechanistic basis for understanding lithium's neuroprotective effects.
C1 [Bengesser, Susanne A.; Lackner, Nina; Birner, Armin; Platzer, Martina; Fellendorf, Frederike T.; Queissner, Robert; Filic, Kristijan; Kapfhammer, Hans-Peter; Reininghaus, Eva Z.] Med Univ Graz, Dept Psychiat, Auenbruggerpl 31, A-8036 Graz, Austria.
   [Wallner-Liebmann, Sandra J.] Med Univ Graz, Dept Pathophysiol & Immunol, A-8036 Graz, Austria.
   [Mangge, Harald; Zelzer, Sieglinde] Med Univ Graz, Clin Dept Med & Chem Lab Diagnost, A-8036 Graz, Austria.
   [Fuchs, Dietmar] Med Univ Graz, Dept Chem Lab Diagnost, A-8036 Graz, Austria.
   [Reininghaus, Bernd] Therapiezentrum Justuspk, Bad Hall, Austria.
   [McIntyre, Roger S.] Univ Toronto, Univ Hlth Network, Mood Disorders Psychopharmacol Unit, Toronto, ON, Canada.
C3 Medical University of Graz; Medical University of Graz; Medical
   University of Graz; Medical University of Graz; University of Toronto;
   University Health Network Toronto
RP Lackner, N (corresponding author), Med Univ Graz, Dept Psychiat, Auenbruggerpl 31, A-8036 Graz, Austria.
EM Nina.Lackner@medunigraz.at
RI Fuchs, Dietmar/AAL-8011-2021; McIntyre, Roger/AAU-1000-2020
OI Reininghaus, Eva/0000-0001-5964-4087; Mangge,
   Harald/0000-0003-4067-247X; Fellendorf, Frederike/0000-0001-7215-3848
FU "Stadt Graz" (Project: "Fettstoffwechselstorungen und anthropometrische
   Besonderheiten bei PatientInnen mit bipolarer affektiver Storung");
   "Osterreichische kardiologische Gesellschaft" (Project: "BIPFAT -
   neurobiological background of cardiovascular comorbidities and obesity
   in bipolar disorder")
FX The pilot study was funded by the "Stadt Graz" (Project:
   "Fettstoffwechselstorungen und anthropometrische Besonderheiten bei
   PatientInnen mit bipolarer affektiver Storung") and the "Osterreichische
   kardiologische Gesellschaft" (Project: "BIPFAT - neurobiological
   background of cardiovascular comorbidities and obesity in bipolar
   disorder").
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NR 74
TC 22
Z9 27
U1 0
U2 12
PU BENTHAM SCIENCE PUBL
PI BUSUM
PA PO BOX 294, BUSUM, 1400 AG, NETHERLANDS
SN 1871-5273
EI 1996-3181
J9 CNS NEUROL DISORD-DR
JI CNS Neurol. Disord.-Drug Targets
PY 2016
VL 15
IS 4
BP 381
EP 389
DI 10.2174/1871527315666160321104059
PG 9
WC Neurosciences; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pharmacology & Pharmacy
GA DI9DU
UT WOS:000373802500004
PM 26996179
DA 2025-06-11
ER

PT J
AU Mariana, M
   Castelo-Branco, M
   Soares, AM
   Cairrao, E
AF Mariana, Melissa
   Castelo-Branco, Miguel
   Soares, Amadeu M.
   Cairrao, Elisa
TI Phthalates' exposure leads to an increasing concern on cardiovascular
   health
SO JOURNAL OF HAZARDOUS MATERIALS
LA English
DT Review
DE Endocrine disrupting compounds; Plasticizers; Human health;
   Cardiovascular diseases; Cardiometabolic risk factors
ID CORONARY-HEART-DISEASE; BODY-MASS INDEX; ENDOCRINE-DISRUPTING CHEMICALS;
   BISPHENOL-A; METABOLITE CONCENTRATIONS; URINARY CONCENTRATIONS;
   BLOOD-PRESSURE; CARDIOMETABOLIC RISK; INSULIN-RESISTANCE; OXIDATIVE
   STRESS
AB Being an essential component in the plastics industry, phthalates are ubiquitous in the environment and in everyday life. They are considered environmental contaminants that have been classified as endocrine-disrupting compounds. Despite di-2-ethylhexyl phthalate (DEHP) being the most common plasticizer and the most studied to date, there are many others that, in addition to being widely used in the plastic, are also applied in the medical and pharmaceutical industries and cosmetics. Due to their wide use, phthalates are easily absorbed by the human body where they can disrupt the endocrine system by binding to molecular targets and interfering with hormonal homeostasis. Thus, phthalates exposure has been implicated in the development of several diseases in different age groups. Collecting information from the most recent available literature, this review aims to relate human phthalates' exposure with the development of cardiovascular diseases throughout all ages. Overall, most of the studies presented demonstrated an association between phthalates and several cardiovascular diseases, either from prenatal or postnatal exposure, affecting foetuses, infants, children, young and older adults. However, the mechanisms underlying these effects remain poorly explored. Thus, considering the cardiovascular diseases incidence worldwide and the constant human exposure to phthalates, this topic should be extensively studied to understand the mechanisms involved.
C1 [Mariana, Melissa; Castelo-Branco, Miguel; Cairrao, Elisa] Univ Beira Interior, CICS UBI Hlth Sci Res Ctr, P-6200506 Covilha, Portugal.
   [Castelo-Branco, Miguel; Cairrao, Elisa] Univ Beira Interior, FCS UBI Fac Hlth Sci, P-6200506 Covilha, Portugal.
   [Soares, Amadeu M.] Univ Aveiro, CESAM Ctr Environm & Marine Studies, Dept Biol, P-3810193 Aveiro, Portugal.
   [Cairrao, Elisa] Univ Beira Interior, Ctr Invest Ciencias Saude, Ave Infante D Henr s-n, P-6200506 Covilha, Portugal.
C3 Universidade da Beira Interior; Universidade da Beira Interior;
   Universidade de Aveiro; Universidade da Beira Interior
RP Cairrao, E (corresponding author), Univ Beira Interior, Ctr Invest Ciencias Saude, Ave Infante D Henr s-n, P-6200506 Covilha, Portugal.
EM ecairrao@fcsaude.ubi.pt
RI Sousa, Miguel/F-7869-2010; Soares, Amadeu/A-8304-2008; Cairrao,
   Elisa/AAB-1164-2020
OI Soares, Amadeu/0000-0003-0879-9470; Mariana,
   Melissa/0000-0003-1875-0144; Cairrao, Elisa/0000-0002-4823-5701
FU Portuguese Foundation for Science and Technology/MCTES [UIDB/00709/2020,
   UIDP/00709/2020]; FCT; FCT/MCTES [2020.07020. BD];  [UIDP/50017/2020 +
   UIDB/50017/2020 + LA/P/0094/2020]
FX This work was developed within the scope of the CICS-UBI projects
   UIDB/00709/2020 and UIDP/00709/2020, financed by national funds through
   the Portuguese Foundation for Science and Technology/MCTES. Melissa
   Mariana acknowledges the PhD fellowship from FCT (Reference: 2020.07020.
   BD) . Thanks are due to FCT/MCTES for the financial support to CESAM
   (UIDP/50017/2020 + UIDB/50017/2020 + LA/P/0094/2020) , through national
   funds. The authors would like to acknowledge to the anonymous reviewers
   for their suggestions and significant contribution for the improvement
   of the manuscript. To make the figures we used pictures from Smart
   Servier Medical Art, licensed under a Creative Commons Attribution 3.0
   unported license (https://smart.servier.com /) .
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NR 184
TC 61
Z9 66
U1 17
U2 66
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0304-3894
EI 1873-3336
J9 J HAZARD MATER
JI J. Hazard. Mater.
PD SEP 5
PY 2023
VL 457
AR 131680
DI 10.1016/j.jhazmat.2023.131680
EA JUN 2023
PG 21
WC Engineering, Environmental; Environmental Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering; Environmental Sciences & Ecology
GA K0OL0
UT WOS:001013526800001
PM 37269565
OA hybrid
DA 2025-06-11
ER

PT J
AU Sarafidis, PA
   Bakris, GL
AF Sarafidis, Pantelis A.
   Bakris, George L.
TI The antinatriuretic effect of insulin: An unappreciated mechanism for
   hypertension associated with insulin resistance?
SO AMERICAN JOURNAL OF NEPHROLOGY
LA English
DT Review
DE insulin; sodium retention; insulin resistance; hyperinsulinemia; salt
   sensitivity; oxidative stress
ID SALT-SENSITIVE HYPERTENSION; BLOOD-PRESSURE RESPONSE; ANGIOTENSINOGEN
   GENE-EXPRESSION; CARDIOVASCULAR RISK-FACTORS; DIETARY-SODIUM CHLORIDE;
   PROTEIN-KINASE PATHWAY; PROXIMAL TUBULAR CELLS; SMOOTH-MUSCLE-CELLS;
   OXIDATIVE STRESS; RENAL SODIUM
AB Insulin resistance is proposed to be causally related to the metabolic syndrome disorders, but a direct cause-and-effect relationship between insulin resistance and hypertension was not originally obvious. Previous data suggested that insulin promotes sodium retention from the kidney, and thus research efforts focused on this action among several other possible pathways connecting insulin resistance and hyperinsulinemia with hypertension. A review of numerous studies provides evidence that this antinatriuretic effect of insulin is preserved in states of metabolic insulin resistance, representing a major mechanism for blood pressure elevation. More recent experimental and clinical studies have added data about the exact tubular sites of this insulin action, its relation with the respective insulin action on potassium handling, its possible role in the development of salt sensitivity in essential hypertension, as well as the involvement of oxidant stress in these associations. This review summarizes the current state of knowledge in this area and attempts to highlight an important but rather overlooked pathway for hypertension development in the metabolic syndrome, the influence of high insulin levels leading to volume expansion. Copyright (c) 2007 S. Karger AG, Basel.
C1 Aristotle Univ Thessaloniki, Dept Med 1, AHEPA Hosp, GR-54066 Thessaloniki, Greece.
   Univ Chicago, Dept Med, Div Endocrine, Hypertens Ctr, Chicago, IL 60637 USA.
C3 Aristotle University of Thessaloniki; Ahepa University Hospital;
   University of Chicago
RP Sarafidis, PA (corresponding author), Aristotle Univ Thessaloniki, Dept Med 1, AHEPA Hosp, St Kiriakidi 1, GR-54066 Thessaloniki, Greece.
EM psarafidis11@yahoo.gr
RI Bakris, George/AFC-1168-2022; Sarafidis, Pantelis/AFO-2131-2022
OI Sarafidis, Pantelis/0000-0002-9174-4018
CR [Anonymous], CLIN HYPERTENSION
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NR 101
TC 62
Z9 66
U1 0
U2 3
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0250-8095
J9 AM J NEPHROL
JI Am. J. Nephrol.
PY 2007
VL 27
IS 1
BP 44
EP 54
DI 10.1159/000098955
PG 11
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 136XC
UT WOS:000244256400007
PM 17245074
DA 2025-06-11
ER

PT J
AU Rice, AJ
   Schvey, NA
   Shank, LM
   Neyland, MKH
   Lavender, JM
   Solomon, S
   Hennigan, K
   Schindler, R
   Sbrocco, T
   Jorgensen, S
   Stephens, M
   Haigney, M
   Klein, DA
   Quinlan, J
   Yanovski, JA
   Tanofsky-Kraff, M
AF Rice, Alexander J.
   Schvey, Natasha A.
   Shank, Lisa M.
   Neyland, M. K. Higgins
   Lavender, Jason M.
   Solomon, Senait
   Hennigan, Kathrin
   Schindler, Rachel
   Sbrocco, Tracy
   Jorgensen, Sarah
   Stephens, Mark
   Haigney, Mark
   Klein, David A.
   Quinlan, Jeffrey
   Yanovski, Jack A.
   Tanofsky-Kraff, Marian
TI Weight-Based Teasing and Metabolic Syndrome Components among Adolescent
   Military Dependents at Risk for Adult Obesity
SO CHILDHOOD OBESITY
LA English
DT Article
DE adolescents; metabolic syndrome; military; obesity; overweight;
   weight-based teasing
ID BULLYING VICTIMIZATION; BIAS INTERNALIZATION; STIGMA; CHILDHOOD;
   OVERWEIGHT; HEALTH; DISCRIMINATION; EXPERIENCES; CORTISOL; CHILDREN
AB Background: Among adults, weight stigma is associated with markers of poor cardiometabolic health. Although weight-based teasing (WBT) is common among youth with high body weight, few studies have examined its associations with cardiometabolic markers. Owing to unique stressors (e.g., parental deployment and frequent moves), military-dependent youth may be at particularly high risk for obesity, WBT, and poor cardiometabolic health. We, therefore, assessed associations between WBT and cardiometabolic health markers among adolescent military dependents presenting for a weight gain prevention trial.
   Methods: Participants underwent fasting phlebotomy; had fasting weight, height, and waist circumference measured; and completed assessments of WBT, anxiety, and loss-of-control eating. Multivariate analysis of covariance, adjusting for relevant covariates including demographics and body composition, was used to examine differences in metabolic syndrome (MetS) components (waist circumference, systolic and diastolic blood pressure, high-density lipoprotein cholesterol, triglycerides, and glucose) between youth reporting WBT and youth reporting no WBT. Bootstrapped models examined whether WBT mediated the relationship between BMIz and MetS components.
   Results: Data from 142 youth (57.7% female; 14.4 +/- 1.6 years; 51.2% non-Hispanic White, 20.9% non-Hispanic Black; BMIz: 1.9 +/- 0.4) were analyzed. WBT was not significantly associated with any MetS component. Relationships were observed between BMIz and all MetS components (except systolic blood pressure and glucose), although WBT did not significantly mediate these relationships (p's > 0.05).
   Conclusions: This study did not find support for a relationship between WBT and MetS components in adolescent military dependents at risk for adult obesity. Prospective research is needed to determine whether associations between WBT and adverse cardiometabolic outcomes emerge primarily in adulthood.
C1 [Rice, Alexander J.; Shank, Lisa M.; Neyland, M. K. Higgins; Lavender, Jason M.; Hennigan, Kathrin; Schindler, Rachel; Haigney, Mark; Tanofsky-Kraff, Marian] Uniformed Serv Univ Hlth Sci, Dept Med, Room A3060, Bethesda, MD 20814 USA.
   [Rice, Alexander J.; Shank, Lisa M.; Neyland, M. K. Higgins; Lavender, Jason M.; Solomon, Senait; Hennigan, Kathrin; Schindler, Rachel; Haigney, Mark; Tanofsky-Kraff, Marian] Uniformed Serv Univ Hlth Sci, Mil Cardiovasc Outcomes Res MiCOR Program, Bethesda, MD 20814 USA.
   [Rice, Alexander J.; Shank, Lisa M.; Neyland, M. K. Higgins; Lavender, Jason M.; Hennigan, Kathrin; Schindler, Rachel] Metis Fdn, San Antonio, TX USA.
   [Schvey, Natasha A.; Shank, Lisa M.; Solomon, Senait; Sbrocco, Tracy; Tanofsky-Kraff, Marian] Uniformed Serv Univ Hlth Sci, Dept Med & Clin Psychol, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA.
   [Schvey, Natasha A.; Shank, Lisa M.; Yanovski, Jack A.; Tanofsky-Kraff, Marian] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Sect Growth & Obes, Div Intramural Res, NIH,DHHS, Bethesda, MD USA.
   [Solomon, Senait] Henry M Jackson Fdn Adv Mil Med HJF, Bethesda, MD USA.
   [Jorgensen, Sarah] Ft Belvoir Community Hosp, Ft Belvoir, VA USA.
   [Stephens, Mark] Penn State Univ, State Coll, PA USA.
   [Klein, David A.; Quinlan, Jeffrey] Uniformed Serv Univ Hlth Sci, Dept Family Med, Bethesda, MD 20814 USA.
   [Klein, David A.] Uniformed Serv Univ Hlth Sci, Dept Pediat, Bethesda, MD 20814 USA.
C3 Uniformed Services University of the Health Sciences - USA; Uniformed
   Services University of the Health Sciences - USA; Uniformed Services
   University of the Health Sciences - USA; National Institutes of Health
   (NIH) - USA; NIH Eunice Kennedy Shriver National Institute of Child
   Health & Human Development (NICHD); Division of Intramural Research
   (DIR); Henry M. Jackson Foundation for the Advancement of Military
   Medicine, Inc; Pennsylvania Commonwealth System of Higher Education
   (PCSHE); Pennsylvania State University; Pennsylvania State University -
   University Park; Uniformed Services University of the Health Sciences -
   USA; Uniformed Services University of the Health Sciences - USA
RP Schvey, NA (corresponding author), Uniformed Serv Univ Hlth Sci, Dept Med & Clin Psychol, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA.
EM natasha.schvey@usuhs.edu
RI Stephens, Mark/A-2679-2015; Shank, Lisa/I-7079-2015
OI , Mark/0000-0003-0156-1638; Jorgensen, Sarah/0000-0003-4167-4688;
   Quinlan, Jeffrey/0000-0001-9335-6820; Rice,
   Alexander/0009-0003-9902-807X; Haigney, Mark/0000-0001-6449-4386;
   Yanovski, Jack/0000-0001-8542-1637
FU NIDDK [1R01DK104115-01]; Defense Health Agency [MED 83-10180]; Eunice
   Kennedy Shriver National Institute of Child Health and Human Development
   [ZIA-HD-00641]
FX This research was supported by NIDDK 1R01DK104115-01 to M.T.-K., and the
   Defense Health Agency, MED 83-10180 to M.H. J.A.Y. is supported by the
   Intramural Research Program, Eunice Kennedy Shriver National Institute
   of Child Health and Human Development, ZIA-HD-00641.
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NR 73
TC 1
Z9 2
U1 0
U2 7
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 2153-2168
EI 2153-2176
J9 CHILD OBES
JI Child Obes.
PD MAR 1
PY 2021
VL 17
IS 2
BP 116
EP 124
DI 10.1089/chi.2020.0256
EA JAN 2021
PG 9
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Pediatrics
GA QY0AJ
UT WOS:000607615900001
PM 33434443
OA Green Published
DA 2025-06-11
ER

PT J
AU Lira, ME
   Loomis, AK
   Paciga, SA
   Lloyd, DB
   Thompson, JF
AF Lira, Maruja E.
   Loomis, A. Katrina
   Paciga, Sara A.
   Lloyd, David B.
   Thompson, John F.
TI Expression of CETP and of splice variants induces the same level of ER
   stress despite secretion efficiency differences
SO JOURNAL OF LIPID RESEARCH
LA English
DT Article
DE HDL-cholesterol; atherosclerosis; Alu sequence; endoplasmic reticulum;
   cholesteryl ester transfer protein
ID ESTER TRANSFER PROTEIN; ENDOPLASMIC-RETICULUM STRESS; INSULIN-RESISTANCE
   SYNDROME; HDL-CHOLESTEROL LEVELS; MESSENGER-RNA; ADIPOSE-TISSUE; TAQIB
   POLYMORPHISM; GENE; INHIBITION; DISEASE
AB The cholesteryl ester transfer protein (CETP) gene has been associated with a variety of phenotypes, including HDL-cholesterol levels and, more sporadically, with cardiovascular disease, obesity, and extreme longevity. Alterations of CETP activity levels can be caused by single-base polymorphisms as well as by alternative splicing. In addition to the previously characterized alternative splicing that skips exon 9, we found additional minor variants and characterized the activity of the resultant proteins. The novel variants skipped exon 9 sequences and inserted one of two in-frame exons from Alu-derived intronic sequences. None of the alternatively spliced variants are efficiently secreted, and co-expression of them inhibits wild-type CETP secretion. Expression of the alternative spliced variants causes an induction of genes linked to the endoplasmic reticulum (ER) stress response, including the neighboring HERPUD1 (homocysteine- and ER stress-inducible protein, ubiquitin- like domain-containing) gene. Unexpectedly, even though wild-type CETP is secreted much more efficiently than spliced variants, it induces the same degree of stress response as spliced variants, whereas a control secreted protein does not. CETP plays a complex role in modulating ER stress, with its expression inducing the response and its cholesteryl ester transfer activity and differential splicing modulating the response in other ways.-Lira, M. E., A. K. Loomis, S. A. Paciga, D. B. Lloyd, and J. F. Thompson. Expression of CETP and of splice variants induces the same level of ER stress despite secretion efficiency differences.
C1 [Lira, Maruja E.; Loomis, A. Katrina; Paciga, Sara A.; Lloyd, David B.; Thompson, John F.] Pfizer Global Res & Dev, Mol Med, Groton, CT 06340 USA.
C3 Pfizer; Pfizer USA
RP Lira, ME (corresponding author), Pfizer Global Res & Dev, Mol Med, Groton, CT 06340 USA.
EM jthompson@helicosbio.com
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NR 31
TC 19
Z9 20
U1 0
U2 5
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0022-2275
EI 1539-7262
J9 J LIPID RES
JI J. Lipid Res.
PD SEP
PY 2008
VL 49
IS 9
BP 1955
EP 1962
DI 10.1194/jlr.M800078-JLR200
PG 8
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 337YX
UT WOS:000258472500011
PM 18509195
OA hybrid
DA 2025-06-11
ER

PT J
AU Delos Reyes, FSLG
   Mamaril, ACC
   Matias, TJP
   Tronco, MKV
   Samson, GR
   Javier, ND
   Fadriquela, A
   Antonio, JM
   Sajo, MEJV
AF Delos Reyes, Felippe Steven Louis G.
   Mamaril, Adrian Carlo C.
   Matias, Trisha Joy P.
   Tronco, Mary Kathleen V.
   Samson, Gabriel R.
   Javier, Nyczl D.
   Fadriquela, Ailyn
   Antonio, Jayson M.
   Sajo, Ma Easter Joy V.
TI The Search for the Elixir of Life: On the Therapeutic Potential of
   Alkaline Reduced Water in Metabolic Syndromes
SO PROCESSES
LA English
DT Review
DE metabolic syndrome; alkaline ionized water; alkaline-ionized water;
   alkaline reduced water; obesity; diabetes; cancer; non-alcoholic fatty
   liver disease; microbiota; exercise
ID HYDROGEN-RICH WATER; FATTY LIVER-DISEASE; ELECTROLYZED WATER; OXIDATIVE
   STRESS; GUT MICROBIOTA; DIABETES-MELLITUS; ADIPOSE-TISSUE;
   ANIMAL-MODELS; CANCER; HEALTH
AB Our body composition is enormously influenced by our lifestyle choices, which affect our health and longevity. Nutrition and physical activities both impact overall metabolic condition, thus, a positive energy balance causes oxidative stress and inflammation, hastening the development of metabolic syndrome. With this knowledge, boosting endogenous and exogenous antioxidants has emerged as a therapeutic strategy for combating metabolic disorders. One of the promising therapeutic inventions is the use of alkaline reduced water (ARW). Aside from its hydrating and non-caloric properties, ARW has demonstrated strong antioxidant and anti-inflammatory properties that can help stabilize physiologic turmoil caused by oxidative stress and inflammation. This review article is a synthesis of studies where we elaborate on the intra- and extracellular effects of drinking ARW, and relate these to the pathophysiology of common metabolic disorders, such as obesity, diabetes mellitus, non-alcoholic fatty liver disease, and some cancers. Highlighting the health-promoting benefits of ARW, we also emphasize the importance of maintaining a healthy lifestyle by incorporating exercise and practicing a balanced diet as forms of habit.
C1 [Delos Reyes, Felippe Steven Louis G.; Mamaril, Adrian Carlo C.; Matias, Trisha Joy P.; Tronco, Mary Kathleen V.; Samson, Gabriel R.; Javier, Nyczl D.; Antonio, Jayson M.; Sajo, Ma Easter Joy V.] Univ Philippines Baguio, Dept Biol, Coll Sci, Baguio 2600, Philippines.
   [Fadriquela, Ailyn] Yonsei Univ, Wonju Coll Med, Dept Lab Med, Wonju 26426, South Korea.
   [Antonio, Jayson M.] Yonsei Univ, Wonju Coll Med, Dept Microbiol, Wonju 26426, South Korea.
C3 University of the Philippines System; University of the Philippines
   Baguio; Yonsei University; Yonsei University
RP Sajo, MEJV (corresponding author), Univ Philippines Baguio, Dept Biol, Coll Sci, Baguio 2600, Philippines.
EM fgdelosreyes@up.edu.ph; acmamaril2@up.edu.ph; tpmatias@up.edu.ph;
   mvtronco@up.edu.ph; grsamson@up.edu.ph; ndjavier@up.edu.ph;
   ailyn@yonsei.ac.kr; fyeflowright03@gmail.com; mvsajo@up.edu.ph
RI Fadriquela, Ailyn/JEZ-2749-2023; Sajo, Ma Easter Joy/HJB-4349-2022;
   Antonio, Jayson/JAN-6264-2023
OI Delos Reyes, Felippe Steven Louis/0000-0002-2270-4055; Matias, Trisha
   Joy/0000-0001-6413-2107; Fadriquela, Ailyn/0000-0002-7860-4539; Antonio,
   Jayson/0000-0001-6855-5617; Mamaril, Adrian Carlo/0000-0002-2842-0790;
   Tronco, Mary Kathleen/0000-0003-0311-0558
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NR 124
TC 11
Z9 11
U1 3
U2 17
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2227-9717
J9 PROCESSES
JI Processes
PD NOV
PY 2021
VL 9
IS 11
AR 1876
DI 10.3390/pr9111876
PG 20
WC Engineering, Chemical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering
GA XF5MJ
UT WOS:000724113900001
OA gold
DA 2025-06-11
ER

PT J
AU Saidi, AO
   Akintayo, CO
   Atuma, CL
   Mahmud, H
   Sabinari, IW
   Oniyide, AA
   Aturamu, A
   Agunbiade, TB
   Olaniyi, KS
AF Saidi, Azeezat O.
   Akintayo, Christopher O.
   Atuma, Chukwubueze L.
   Mahmud, Hadiza
   Sabinari, Isaiah W.
   Oniyide, Adesola A.
   Aturamu, Ayodeji
   Agunbiade, Toluwani B.
   Olaniyi, Kehinde S.
TI Melatonin supplementation preserves testicular function by attenuating
   lactate production and oxidative stress in high fat diet-induced obese
   rat model
SO THERIOGENOLOGY
LA English
DT Article
DE High fat; Lactate; Melatonin; Oxidative stress; Testicular function
ID METABOLIC SYNDROME; SODIUM-ACETATE; DAMAGE; INSULIN; TESTOSTERONE;
   HOMEOSTASIS; DYSFUNCTION; EXPRESSION; GLUCOSE; PROTEIN
AB Metabolic syndrome, including obesity has been documented as a critical factor in male reproductive dysfunction with subsequent reduction in male fertility. The therapeutic potential of melatonin has been demonstrated against oxidative stress-induced pathologies. Therefore, the present study investigated the effects of melatonin on testicular dysfunction associated with high fat diet (FD)-induced obese rat model, and the possible involvement of peroxisome proliferator-activated receptor-gamma (PPAR-gamma). Adult male Wistar rats (n = 6/group) were used: control group received vehicle (normal saline), obese group received 40% FD, melatonin-treated group received melatonin (4 mg/kg), and obese plus melatonin group received melatonin and 40% FD and the treatment lasted for 12 weeks. High fat diet caused increased body weight and testicular triglyceride, total cholesterol, malondialdehyde, gamma-glutamyl transferase, lactate production and lactate/pyruvate ratio as well as decreased glutathione/glutathione peroxidase, nitric oxide and PPAR-gamma and circulating testosterone. Nevertheless, all these alterations were attenuated when supplemented with melatonin. Taken together, these results demonstrates that FD-induced obesity causes testicular dysfunction. In addition, the results suggest that melatonin supplementation protects against obesity-associated testicular dysfunction and this effect is accompanied by upregulation of PPAR-gamma. (C) 2022 Elsevier Inc. All rights reserved.
C1 [Saidi, Azeezat O.; Akintayo, Christopher O.; Atuma, Chukwubueze L.; Mahmud, Hadiza; Oniyide, Adesola A.; Aturamu, Ayodeji; Olaniyi, Kehinde S.] Afe Babalola Univ, Dept Physiol, Coll Med & Hlth Sci, Ado Ekiti 360101, Nigeria.
   [Sabinari, Isaiah W.; Olaniyi, Kehinde S.] Univ Ilorin, HOPE Cardiometabol Res Team Dept Physiol, Coll Hlth Sci, P M B, 1515, Ilorin, Nigeria.
   [Agunbiade, Toluwani B.] Afe Babalola Univ, Dept Med Microbiol, Coll Med & Hlth Sci, Ado Ekiti 360101, Nigeria.
C3 University of Ilorin
RP Olaniyi, KS (corresponding author), Afe Babalola Univ, Dept Physiol, Coll Med & Hlth Sci, Ado Ekiti 360101, Nigeria.; Olaniyi, KS (corresponding author), Univ Ilorin, HOPE Cardiometabol Res Team Dept Physiol, Coll Hlth Sci, P M B, 1515, Ilorin, Nigeria.
EM olaniyisk@abuad.edu.ng
RI Olaniyi, Kehinde/GPK-5850-2022
OI Olaniyi, Kehinde/0000-0002-8229-9688
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NR 49
TC 5
Z9 5
U1 0
U2 7
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0093-691X
EI 1879-3231
J9 THERIOGENOLOGY
JI Theriogenology
PD JUL 15
PY 2022
VL 187
BP 19
EP 26
DI 10.1016/j.theriogenology.2022.02.029
EA APR 2022
PG 8
WC Reproductive Biology; Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Reproductive Biology; Veterinary Sciences
GA 6E1CR
UT WOS:000883122900003
PM 35500423
DA 2025-06-11
ER

PT J
AU González, CY
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   Oros-Pantoja, Rigoberto
   Colin-Ferreyra, Maria del Carmen
   Benitez-Arciniega, Alejandra Donaji
   Soto Pina, Alexandra Estela
   Aguirre-Garrido, Jose Felix
TI The Gut Microbiota Is Involved in the Regulation of Cognitive
   Flexibility in Adolescent BALB/c Mice Exposed to Chronic Physical Stress
   and a High-Fat Diet
SO MICROORGANISMS
LA English
DT Article
DE attentional set-shifting test; chronic stress; cognitive flexibility;
   high-fat diet; gut microbiota; prefrontal cortex
ID RNA GENE DATABASE; METABOLIC SYNDROME; MOUSE MODEL; DISEASE; DEPRESSION;
   GREENGENES; BACTERIA; RISK
AB Dysfunction in the prefrontal cortex can lead to cognitive inflexibility due to multifactorial causes as included cardiometabolic disorders, stress, inadequate diets, as well as an imbalance of the gut-brain axis microbiota. However, these risk factors have not been evaluated jointly. The purpose of this study was to evaluate the effect of physical stress (MS: Male Stress and FS: Female Stress) and high-fat diet (MD: Male Diet and FD: Female Diet) supplementation on the gut microbiota and cognitive flexibility. Methods: The study was performed on 47 mice, 30 male (M) and 17 female (F) BALBc, exposed to chronic stress physical (S) and high-fat diet (D). Cognitive flexibility was evaluated using the Attentional Set-Shifting Test (ASST) and the gut microbiota composition in terms of relative abundance (%) and alpha-beta diversity. Results: Results showed that S and D reduced cognitive flexibility in male and female mice (p < 0.0001). Significant changes occurred in Alistipes spp. (MM vs. MS:MD; p < 0.0001), Barnesiella spp. (FC vs. FS; p = 0.0002; FC vs. FD, p = 0.0033); Dorea spp. (MC vs. MD, p = 0.0008; MM vs. MD, p < 0.0001) and Lactobacillus spp. (MC vs. MD and FM vs. FS, p < 0.0001; FM vs. MD, p = 0.0393) genera among groups. Predictive functional analysis (QIIME2 and PICRUSt2) showed a significant increase in the expression of histidine kinase, alanine dehydrogenase, glutamine synthase, glutamate synthase, arginine succinyl synthase, and tryptophan synthase genes (p < 0.05), the latter being a precursor of serotonin (5-HT). Conclusions: Chronic physical stress and a high-fat diet modify cognitive flexibility and the composition and predictive function of the gut microbiota.
C1 [Gonzalez, Cristian Yuriana; Estrada, Jose Antonio; Oros-Pantoja, Rigoberto; Colin-Ferreyra, Maria del Carmen; Benitez-Arciniega, Alejandra Donaji; Soto Pina, Alexandra Estela] Autonomous Univ State Mexico, Sch Med, Paseo Tollocan & Jesus Carranza, Toluca De Lerdo 50180, State Of Mexico, Mexico.
   [Aguirre-Garrido, Jose Felix] Autonomous Metropolitan Univ Lerma, Dept Biotechnol & Environm Microbiol, Hidalgo Pte 46, Lerma 52006, State Of Mexico, Mexico.
C3 Universidad Autonoma del Estado de Mexico
RP Piña, AES (corresponding author), Autonomous Univ State Mexico, Sch Med, Paseo Tollocan & Jesus Carranza, Toluca De Lerdo 50180, State Of Mexico, Mexico.
EM cgonzalez002@alumno.uaemex.mx; jaestradag@uaemex.mx; rorosp@uaemex.mx;
   mdcolinf@uaemex.mx; abeniteza@uaemex.mx; aesotop@uaemex.mx;
   j.aguirre@correo.ler.uam.mx
RI Fernández-González, Antonio/H-5942-2015; Oros-Pantoja,
   Rigoberto/O-1494-2019; Estrada, José/B-1500-2016; Soto,
   Alexandra/AAH-4797-2021; Oros-Pantoja, Rigoberto/B-3370-2016
OI Oros-Pantoja, Rigoberto/0000-0001-5441-0863; Aguirre Garrido, Jose
   Felix/0000-0002-4017-3753; Gonzalez, Cristian
   Yuriana/0000-0001-8285-7814; Soto Pina, Alexandra
   Estela/0000-0002-3289-5510
FU Secretaria de Investigacion y Estudios Avanzados of Universidad Autonoma
   del Estado de Mexico [6199-2020CIB]
FX This research was funded by the Secretaria de Investigacion y Estudios
   Avanzados of Universidad Autonoma del Estado de Mexico (Project number:
   6199-2020CIB).
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NR 87
TC 0
Z9 0
U1 7
U2 7
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-2607
J9 MICROORGANISMS
JI Microorganisms
PD DEC
PY 2024
VL 12
IS 12
AR 2542
DI 10.3390/microorganisms12122542
PG 18
WC Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Microbiology
GA Q6H6X
UT WOS:001385669800001
PM 39770745
OA gold
DA 2025-06-11
ER

PT J
AU Jeh, SU
   Yoon, S
   Choi, JH
   Do, J
   Seo, DH
   Lee, SW
   Choi, SM
   Lee, C
   Kam, SC
   Hwa, JS
   Chung, KH
   Kang, HW
   Hyun, JS
AF Jeh, Seong Uk
   Yoon, Sol
   Choi, Jae Hwi
   Do, Jungmo
   Seo, Deok Ha
   Lee, Sin Woo
   Choi, See Min
   Lee, Chunwoo
   Kam, Sung Chul
   Hwa, Jeong Seok
   Chung, Ky Hyun
   Kang, Ho Won
   Hyun, Jae Seog
TI Metabolic Syndrome Is an Independent Risk Factor for Acquired Premature
   Ejaculation
SO WORLD JOURNAL OF MENS HEALTH
LA English
DT Article
DE Metabolic syndrome; Obesity; Premature ejaculation; Risk factors; Sexual
   dysfunctions; Type 2 diabetes
ID AD-HOC COMMITTEE; INTERNATIONAL-SOCIETY; ERECTILE DYSFUNCTION;
   TESTOSTERONE LEVELS; SEXUAL ATTITUDES; NITRIC-OXIDE; PREVALENCE; MEN;
   ASSOCIATIONS; DEFINITION
AB Purpose: To determine the role of metabolic syndrome (MetS) as a risk factor for acquired premature ejaculation (PE) after considering the various risk factors, such as lower urinary tract symptoms, erectile dysfunction, hypogonadism, and prostatitis.
   Materials and Methods: From January 2012 to January 2017, records of 1,029 men were analyzed. We performed multivariate analysis to identify risk factors for PE, including the covariate of age, marital status, International Prostate Symptom Score, International Index of Erectile Function (IIEF) score, National Institutes of Health-Chronic Prostatitis Symptom Index (NIH-CPSI) score, serum testosterone levels, and all components of MetS. Acquired PE was defined as self-reported intravaginal ejaculation latency time <= 3 minutes, and MetS was diagnosed using the modified National Cholesterol Education Program Adult Treatment Panel III criteria.
   Results: Of 1,029 men, 74 subjects (7.2%) had acquired PE and 111 (10.8%) had MetS. Multivariate analysis showed that the IIEF overall satisfaction score (odds ratio [OR]=0.67, p<0.001), NIH-CPSI pain score (OR=1.07, p=0.035), NIH-CPSI voiding score (OR=1.17, p=0.032), and presence of MetS (OR=2.20, p=0.022) were significantly correlated with the prevalence of acquired PE. In addition, the Male Sexual Health Questionnaire for Ejaculatory Dysfunction scores and ejaculation anxiety scores progressively decreased as the number of components of MetS increased.
   Conclusions: MetS may be an independent predisposing factor for the development of acquired PE. Effective prevention and treatment of MetS could also be important for the prevention and treatment of acquired PE.
C1 [Jeh, Seong Uk; Yoon, Sol; Choi, Jae Hwi; Lee, Sin Woo; Choi, See Min; Hwa, Jeong Seok; Chung, Ky Hyun; Hyun, Jae Seog] Gyeongsang Natl Univ, Gyeongsang Natl Univ Hosp, Dept Urol, Sch Med, 79 Gangnam Ro, Jinju 52727, South Korea.
   [Do, Jungmo; Seo, Deok Ha; Lee, Chunwoo; Kam, Sung Chul] Gyeongsang Natl Univ, Dept Urol, Changwon Hosp, Chang Won, South Korea.
   [Kang, Ho Won] Chungbuk Natl Univ, Dept Urol, Coll Med, Cheongju, South Korea.
C3 Gyeongsang National University; Gyeongsang National University Hospital;
   Gyeongsang National University; Chungbuk National University
RP Hyun, JS (corresponding author), Gyeongsang Natl Univ, Gyeongsang Natl Univ Hosp, Dept Urol, Sch Med, 79 Gangnam Ro, Jinju 52727, South Korea.
EM hyunjs@gnu.ac.kr
RI Kim, Seul Kee/A-6076-2015; Choi, See Min/G-8227-2014
OI Lee, Sin Woo/0000-0002-3050-6366; Choi, See Min/0000-0002-6599-2640;
   Lee, Chunwoo/0000-0002-5846-7039; Jeh, Seong Uk/0000-0003-3808-8768;
   Yoon, Sol/0000-0002-3627-3858; KAM, SUNG CHUL/0000-0001-5403-3623
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NR 29
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Z9 18
U1 0
U2 3
PU KOREAN SOC SEXUAL MEDICINE & ANDROLOGY
PI GWANGJU
PA DEPT UROLOGY, CHONNAM NATL UNIV MEDICAL SCH, 671 JEBONG-RO, DONG-GU,
   GWANGJU, 501-757, SOUTH KOREA
SN 2287-4208
EI 2287-4690
J9 WORLD J MENS HEALTH
JI World J. Mens Health
PD MAY
PY 2019
VL 37
IS 2
BP 226
EP 233
DI 10.5534/wjmh.180062
PG 8
WC Andrology; Health Care Sciences & Services; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Health Care Sciences & Services; Urology &
   Nephrology
GA HU7PV
UT WOS:000465475300012
PM 30588783
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Motta, AB
AF Motta, A. B.
TI Mechanisms Involved in Metformin Action in the Treatment of Polycystic
   Ovary Syndrome
SO CURRENT PHARMACEUTICAL DESIGN
LA English
DT Review
DE Polycystic ovary syndrome (PCOS); metformin; diabetes; adolescents;
   pregnancy; ovulation; cardiovascular
ID ACTIVATED PROTEIN-KINASE; MIGRATION INHIBITORY FACTOR; FACTOR-KAPPA-B;
   INNATE IMMUNE-RESPONSES; NECROSIS-FACTOR-ALPHA; FACTOR MIF; INSULIN
   SENSITIVITY; MONONUCLEAR-CELLS; OXIDATIVE STRESS; MESSENGER-RNA
AB The N, N' dimethyl-biguanide : Metformin is an antidiabetic drug that increases glucose utilization in insulin-sensitive tissues. As Polycystic Ovary Syndrome ( PCOS) and diabetes share some altered parameters-such as abnormal glucose: insulin ratio, altered lipidic metabolism and insulin-resistance syndrome-the use of metformin has become increasingly accepted and widespread in the treatment of PCOS. Currently, metformin is used to induce ovulation and during early pregnancy in PCOS patients, however, a complete knowledge of the metformin action has not been achieved yet. This review describes beyond the classical reproductive action of metformin and explores other benefits of the drug. In addition, the present work discusses the molecular mechanisms involved further than the classical pathway that involves the AMP-activated protein kinase.
C1 Univ Buenos Aires, Fac Med, Lab Fisiopatol, CEFYBO, RA-1121 Buenos Aires, DF, Argentina.
C3 University of Buenos Aires
RP Motta, AB (corresponding author), Univ Buenos Aires, Fac Med, Lab Fisiopatol, CEFYBO, Paraguay 2155, RA-1121 Buenos Aires, DF, Argentina.
EM aliciabmotta@yahoo.com
FU Agencia Nacional de Promocion Cientifica y Tecnologica (ANPCyT) [PICT
   949]
FX The author wants to thank the support obtained from Agencia Nacional de
   Promocion Cientifica y Tecnologica (ANPCyT), PICT 949.
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NR 62
TC 7
Z9 8
U1 0
U2 7
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1381-6128
EI 1873-4286
J9 CURR PHARM DESIGN
JI Curr. Pharm. Design
PD SEP
PY 2009
VL 15
IS 26
BP 3074
EP 3077
DI 10.2174/138161209789058101
PG 4
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 485TZ
UT WOS:000269149000008
PM 19754381
OA Green Published
DA 2025-06-11
ER

PT J
AU Lupachyk, S
   Watcho, P
   Obrosov, AA
   Stavniichuk, R
   Obrosova, IG
AF Lupachyk, Sergey
   Watcho, Pierre
   Obrosov, Alexander A.
   Stavniichuk, Roman
   Obrosova, Irma G.
TI Endoplasmic reticulum stress contributes to prediabetic peripheral
   neuropathy
SO EXPERIMENTAL NEUROLOGY
LA English
DT Article
DE Diabetic peripheral neuropathy; Endoplasmic reticulum stress; Eukaryotic
   initiation factor-2 alpha; High-fat diet fed mouse; Motor nerve
   conduction velocity; Prediabetic peripheral neuropathy; Salubrinal;
   Sensory nerve conduction velocity; Streptozotocin; Trimethylamine oxide;
   Unfolded protein response; Zucker (fa/fa) rat
ID ALDOSE REDUCTASE INHIBITION; IMPAIRED GLUCOSE-TOLERANCE; ZUCKER DIABETIC
   FATTY; NERVE-FIBER DENSITY; OXIDATIVE-STRESS; METABOLIC SYNDROME; MOUSE
   MODEL; CHRONIC COMPLICATIONS; ANTIOXIDANT DEFENSE; INSULIN SENSITIVITY
AB Growing evidence suggests that prediabetes and metabolic syndrome are associated with increased risk for the development of microvascular complications including retinopathy, nephropathy, and, most commonly, peripheral painful neuropathy and/or autonomic neuropathy. The etiology of these disabling neuropathies is unclear, and several clinical and experimental studies implicated obesity, impaired fasting glycemia/impaired glucose tolerance, elevated triglyceride and non-esterified fatty acids, as well as oxidative-nitrative stress. Endoplasmic reticulum stress resulting from abnormal folding of newly synthesized proteins and leading to the impairment of metabolism, transcriptional regulation, and gene expression, is emerging as a key mechanism of metabolic diseases including obesity and diabetes. We evaluated the role for this phenomenon in prediabetic neuropathy using two animal models i.e., Zucker (fa/fa) rats and high-fat diet fed mice which displayed obesity and impaired glucose tolerance in the absence of overt hyperglycemia. Endoplasmic reticulum stress manifest in upregulation of the glucose-regulated proteins BiP/GRP78 and GRP94 of unfolded protein response was identified in the sciatic nerve of Zucker rats. A chemical chaperone, trimethylamine oxide, blunted endoplasmic reticulum stress and alleviated sensory nerve conduction velocity deficit, thermal and mechanical hypoalgesia, and tactile allodynia. A selective inhibitor of eukaiyotic initiation factor-2 alpha dephosphorylation, salubrinal, improved glucose intolerance and alleviated peripheral nerve dysfunction in high-fat diet fed mice. Our findings suggest an important role of endoplasmic reticulum stress in the neurobiology of prediabetic peripheral neuropathy, and identify a new therapeutic target. (c) 2013 Elsevier Inc. All rights reserved.
C1 [Lupachyk, Sergey; Watcho, Pierre; Obrosov, Alexander A.; Stavniichuk, Roman; Obrosova, Irma G.] Louisiana State Univ Syst, Pennington Biomed Res Ctr, Baton Rouge, LA 70808 USA.
C3 Louisiana State University System; Louisiana State University;
   Pennington Biomedical Research Center
RP Obrosova, IG (corresponding author), Louisiana State Univ Syst, Pennington Biomed Res Ctr, 6400 Perkins Rd, Baton Rouge, LA 70808 USA.
EM obrosoig@pbrc.edu
FU National Institutes of Health [RO1DK074517, RO1DK077141, RO1DK081147]
FX S.L., P.W., A.A.O., R.S., and I.G.O. were partially supported by the
   National Institutes of Health grants RO1DK074517, RO1DK077141, and
   RO1DK081147 (all to I.G.O.).
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NR 65
TC 60
Z9 70
U1 0
U2 27
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0014-4886
J9 EXP NEUROL
JI Exp. Neurol.
PD SEP
PY 2013
VL 247
BP 342
EP 348
DI 10.1016/j.expneurol.2012.11.001
PG 7
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 204VO
UT WOS:000323399600043
PM 23142188
DA 2025-06-11
ER

PT J
AU Alarcón, YB
   González, FB
   Beiza, IRC
   González, ED
   Ramos, JAC
   Arciniega, ADB
   Ramos, RV
   Piña, AES
AF Becerril Alarcon, Yizel
   Bastida Gonzalez, Fernando
   Camacho Beiza, Isidro Roberto
   Davila Gonzalez, Eduardo
   Cruz Ramos, Jose Alfonso
   Benitez Arciniega, Alejandra Donaji
   Valdes Ramos, Roxana
   Soto Pina, Alexandra Estela
TI Association of GSTT1, GSTM1 and GSTP1 (Ile105Val)
   mRNA Expression with Cardiometabolic Risk Parameters in Women with
   Breast Cancer and Comorbidities
SO CARDIOGENETICS
LA English
DT Article
DE Glutathione S-transferase genotypes; cardiometabolic risk; breast
   cancer; comorbidities
ID GLUTATHIONE-S-TRANSFERASE; GENETIC POLYMORPHISMS; P1 POLYMORPHISMS;
   SUSCEPTIBILITY; POPULATION; DISEASE; ENZYMES; MARKERS
AB Breast cancer (BC) and cardiometabolic diseases share a multifactorial and modifiable etiology, modulated by complex molecular pathways. Glutathione S-transferase (GST) plays a critical role, providing protection against xenobiotics and regulating levels of enzymes and proteins in the cell. GST variants have a significant impact on susceptibility to diseases whose pathogenesis involves oxidative stress, as is the case in many inflammatory diseases such as BC and cardiometabolic pathologies. However, the expression of these polymorphic variants has not been studied in BC. This study aimed to evaluate the presence of GST mRNA isoforms and their association with clinical and cardiometabolic parameters in women with BC. This was a case-control study, and a total of 57 participants were recruited. Concentrations of glucose and lipids in blood were measured in all the participants. GST variants (GSTT1, GSTM1 and GSTP1 Ile105Val polymorphism) were evaluated in all the participants by real-time PCR analysis. There was a significant association (p < 0.05) between the frequency of GSTP1 and LDL-c in the BC group. However, the control group showed significant associations between blood pressure with GSTT1 and GSTP1 variants with total cholesterol (TC), LDL-c, VLDL-c and triacylglycerols (TG). Therefore, GSTT1 and GSTP1 variants could be emerging biomarkers to discriminate between BC cases related or not to cardiometabolic disease factors.
C1 [Becerril Alarcon, Yizel; Benitez Arciniega, Alejandra Donaji; Valdes Ramos, Roxana; Soto Pina, Alexandra Estela] Univ Autonoma Estado Mexico, Fac Med, Toluca 50120, Mexico.
   [Bastida Gonzalez, Fernando; Davila Gonzalez, Eduardo] Lab Estatal Salud Publ Estado Mexico, Lab Biol Mol, Toluca 50130, Mexico.
   [Camacho Beiza, Isidro Roberto] Inst Salud Estado Mexico, Unidad Especializada Med Detecc Canc Mama, Toluca 50180, Mexico.
   [Cruz Ramos, Jose Alfonso] Inst Jalisciense Cancerol, Guadalajara 44280, Jalisco, Mexico.
RP Piña, AES (corresponding author), Univ Autonoma Estado Mexico, Fac Med, Toluca 50120, Mexico.
EM ybecerrila048@alumno.uaemex.mx; mijomeil@hotmail.com;
   camacho_beiza@hotmail.com; lalodevl@gmail.com; josealfonsocr@gmail.com;
   abeniteza@uaemex.mx; rvaldesr@uaemex.mx; aesotop@uaemex.mx
RI valdes-ramos, roxana/B-2184-2016; Soto, Alexandra/AAH-4797-2021;
   Cruz-Ramos, Jose Alfonso/T-1387-2018
OI Cruz-Ramos, Jose Alfonso/0000-0002-5791-612X; Valdes-Ramos,
   Roxana/0000-0003-0093-886X; BECERRIL ALARCON, YIZEL/0000-0001-6219-7361
FU Autonomous Mexico State University [4755/2019/CI]
FX This study was supported by Autonomous Mexico State University (Project
   number 4755/2019/CI).
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NR 53
TC 0
Z9 0
U1 2
U2 4
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 2035-8253
EI 2035-8148
J9 CARDIOGENETICS
JI Cardiogenetics
PD SEP
PY 2022
VL 12
IS 3
BP 235
EP 245
DI 10.3390/cardiogenetics12030022
PG 11
WC Cardiac & Cardiovascular Systems
WE Emerging Sources Citation Index (ESCI)
SC Cardiovascular System & Cardiology
GA 4T7YU
UT WOS:000858328300001
OA gold
DA 2025-06-11
ER

PT J
AU Pingali, U
   Nutalapati, C
   Gundagani, S
AF Pingali, Usharani
   Nutalapati, Chandrasekhar
   Gundagani, Srinivas
TI Effect of Omega-3 Fatty Acid Alone and in Combination with Proprietary
   Chromium Complex on Endothelial Function in Subjects with Metabolic
   Syndrome: A Randomized, Double-Blind, Parallel-Group Clinical Study
SO EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Article
ID PERIPHERAL ARTERIAL-DISEASE; TYPE-2 DIABETES-MELLITUS; OXIDATIVE STRESS;
   FISH-OIL; PHYLLANTHUS-EMBLICA; INSULIN-RESISTANCE; LIPID PROFILE;
   NITRIC-OXIDE; INFLAMMATION; SUPPLEMENTATION
AB Metabolic syndrome (MetS) represents a cluster of metabolic abnormalities that include hypertension, central obesity, insulin resistance, and dyslipidemia and is strongly associated with an increased risk of diabetes, cardiovascular diseases (CVD), and all-cause mortality. Early diagnosis is important to employ lifestyle and risk factor modification. Existing therapies are limited. Studies report positive effect of omega-3 fatty acids (omega-3FA) on symptoms of metabolic syndrome. The present study was undertaken to evaluate the effect of omega-3FA alone and in combination with proprietary chromium complex (PCC) on endothelial function in subjects with metabolic syndrome. In this randomized, double-blind, parallel-group study, subjects were enrolled into the study after ethics committee (EC) approval and informed consent. Eligible subjects were randomized to receive omega-3FA concentrate 2000 mg (Group A-18 subjects), omega-3FA concentrate 2000 mg + PCC200 mcg (Group B-19 subjects), and omega-3FA concentrate 2000 mg + PCC400 mcg (Group C-21 subjects) daily for 12 weeks. Endothelial dysfunction as measured by reflection index (RI), biomarkers of oxidative stress (NO, MDA, and glutathione), and inflammation (hsCRP, endothelin-1, ICAM-1, and VCAM-1) were evaluated at baseline, 4, and 12 weeks. Lipid-profile and platelet-aggregation tests were performed at baseline and 12 weeks. Adverse drug reactions were recorded. Compliance was assessed by pill count method. GraphPad Prism8 was used for statistical analysis. Significant changes were seen from 4 weeks onwards in all the parameters evaluated. Significant improvement in RI% (mean +/- SD = -2.56 +/- 0.77 to -3.27 +/- 0.67-group A, -2.33 +/- 0.76 to 4.72 +/- 0.79-group B; -2.39 +/- 1.13 to 6.46 +/- 1.00-group C) was seen at 12 weeks. Significant improvement in biomarkers of oxidative stress and inflammation was seen with all the treatment groups. Similarly, significant improvement in lipid profile was seen in group B and group C, while group A showed change in HDL, VLDL, and TG. Group C demonstrated the best response in the parameters evaluated. Three patients in group C reported gastrointestinal adverse events, which resolved spontaneously; none stopped the therapy. So, the addition of PCC to omega-3FA may prove to have beneficial effect in reducing cardiovascular morbidity in MetS patients.
C1 [Pingali, Usharani; Nutalapati, Chandrasekhar; Gundagani, Srinivas] Nizams Inst Med Sci, Dept Clin Pharmacol & Therapeut, Hyderabad 500082, Telangana, India.
C3 Nizam's Institute of Medical Sciences
RP Pingali, U (corresponding author), Nizams Inst Med Sci, Dept Clin Pharmacol & Therapeut, Hyderabad 500082, Telangana, India.
EM ushapingali@yahoo.com
OI Pingali, Usharani/0000-0002-9300-8022
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NR 56
TC 1
Z9 1
U1 2
U2 10
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1741-427X
EI 1741-4288
J9 EVID-BASED COMPL ALT
JI Evid.-based Complement Altern. Med.
PD JUN 25
PY 2021
VL 2021
AR 2972610
DI 10.1155/2021/2972610
PG 12
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA TH1SI
UT WOS:000671874500001
PM 34257675
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Foss-Freitas, MC
   Ferraz, RC
   Monteiro, LZ
   Gomes, PM
   Iwakura, R
   de Freitas, LCC
   Foss, MC
AF Foss-Freitas, Maria C.
   Ferraz, Rafael C.
   Monteiro, Luciana Z.
   Gomes, Patricia M.
   Iwakura, Ricardo
   de Freitas, Luiz Carlos C.
   Foss, Milton C.
TI Endoplasmic reticulum stress activation in adipose tissue induces
   metabolic syndrome in individuals with familial partial lipodystrophy of
   the Dunnigan type
SO DIABETOLOGY & METABOLIC SYNDROME
LA English
DT Article
DE Familial partial lipodystrophy; Dunnigan type; Endoplasmic reticulum
   stress; Insulin resistance
ID BLOOD MONONUCLEAR-CELLS; UNFOLDED PROTEIN RESPONSE;
   NECROSIS-FACTOR-ALPHA; INSULIN-RESISTANCE; TRANSLATIONAL CONTROL;
   DIABETIC-PATIENTS; LINKS OBESITY; IN-VITRO; CHAPERONIN; COMPLEX
AB Background: Familial partial lipodystrophy of the Dunnigan type is one of the most common inherited lipodystrophies variables. These individuals have important metabolic disorders that cause predisposition to various diseases. In this study we aimed to demonstrate the relation between the metabolic abnormalities, inflammatory profile and the expression of genes involved in the activation of the endoplasmic reticulum stress (ERS) in subjects with FPLD.
   Methods: We evaluated 14 female FPLD patients and compared with 13 female healthy individuals. The subjects were paired with their respective BMI and age and categorized into two groups: Familial partial lipodystrophy of the Dunnigan type (FPLD) and control. Patients were fasted for 12 h before blood collection for measurement of HbA1c, glucose, insulin, lipids and inflammatory markers. Subcutaneous adipose tissue was collected by puncture aspiration of submental region during ambulatorial surgical aesthetic procedure.
   Results: We demonstrate that patients with FPLD show increased HbA1c (p < 0.01), fasting glucose (p < 0.002) and triglycerides (p < 0.005) while HDL/cholesterol (p < 0.001) was lower when compared to healthy individuals. We found that 64.2% FPLD patients had metabolic syndrome according to International Diabetes Federation definition. We also observe increased AUC of glucose (p < 0.001) and insulin during oGTT, featuring a frame of hyperglycemia and hyperinsulinemia, suggesting insulin resistance. Also we found hyperactivation of several genes responsible for ERS such as ATF-4 (p < 0.01), ATF-6 (p < 0.01), EIF2 alpha 3K (p < 0.005), CCT4 (p < 0.001), CHOP (p < 0.01), CALR (p < 0.001) and CANX (p < 0.005), that corroborate the idea that diabetes mellitus and metabolic syndrome are associated with direct damage to the endoplasmic reticulum homeostasis. Ultimately, we note that individuals with lipodystrophy have an increase in serum interleukins, keys of the inflammatory process, as IL-1 beta, TNF-alpha and IL-6 (p < 0.05 all), compared with healthy individuals, which can be the trigger to insulin resistance in this population.
   Conclusion: Individuals with FPLD besides having typical dysfunctions of metabolic syndrome, show a hyperactivation of ERS associated with increased systemic inflammatory profile, which together may explain the complex clinical aspect of this diseases.
C1 [Foss-Freitas, Maria C.; Ferraz, Rafael C.; Gomes, Patricia M.; Foss, Milton C.] Univ Sao Paulo, Sch Med Ribeirao Preto, Div Endocrinol & Metab, Dept Med, Ribeirao Preto, SP, Brazil.
   [Monteiro, Luciana Z.] Univ Brasilia UNB, Brasilia, DF, Brazil.
   [Iwakura, Ricardo; de Freitas, Luiz Carlos C.] Univ Sao Paulo, Sch Med Ribeirao Preto, Dept Opthalmol Otolaryngol Head & Neck Surg, Ribeirao Preto, SP, Brazil.
C3 Universidade de Sao Paulo; Universidade de Brasilia; Universidade de Sao
   Paulo
RP Foss-Freitas, MC (corresponding author), Univ Sao Paulo, Sch Med Ribeirao Preto, Div Endocrinol & Metab, Dept Med, Ribeirao Preto, SP, Brazil.
EM crisfoss@fmrp.usp.br
RI Gomes, Patricia/D-7103-2019; Foss-Freitas, Maria/AAV-5971-2021; Conti de
   Freitas, Luiz Carlos/F-1226-2013; Ferraz-Bannitz, Rafael/C-2390-2018;
   Foss-Freitas, Maria Cristina/F-1197-2013
OI Conti de Freitas, Luiz Carlos/0000-0002-2153-6512; Ferraz-Bannitz,
   Rafael/0000-0003-4496-4883; Monteiro, Luciana/0000-0001-7484-1185;
   Foss-Freitas, Maria Cristina/0000-0002-1350-1125
FU FAEPA
FX FAEPA.
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NR 42
TC 13
Z9 13
U1 0
U2 2
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1758-5996
J9 DIABETOL METAB SYNDR
JI Diabetol. Metab. Syndr.
PD FEB 9
PY 2018
VL 10
AR 6
DI 10.1186/s13098-017-0301-6
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA FW1WS
UT WOS:000425091700001
PM 29449893
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Luo, ZC
   Fraser, WD
   Julien, P
   Deal, CL
   Audibert, F
   Smith, GN
   Xiong, X
   Walker, M
AF Luo, ZC
   Fraser, WD
   Julien, P
   Deal, CL
   Audibert, F
   Smith, GN
   Xiong, X
   Walker, M
TI Tracing the origins of "fetal origins" of adult diseases: Programming by
   oxidative stress?
SO MEDICAL HYPOTHESES
LA English
DT Article
ID DEPENDENT DIABETES-MELLITUS; LOW-BIRTH-WEIGHT; INSULIN-RESISTANCE;
   THRIFTY PHENOTYPE; BLOOD-PRESSURE; CHANGING PATTERNS; PRETERM INFANTS;
   UNITED-STATES; GROWTH; TRENDS
AB Too small size at birth (due to poor fetal growth and/or preterm delivery) has been associated with substantially elevated risks of the metabolic syndrome (dislipidemia, insulin resistance, hypertension), type 2 diabetes and cardiovascular disease in adulthood. The mechanisms of such "fetal origins" or "programming" of disease phenomenon remain unresolved. Too large size at birth seems also associated with an increased risk. Many known or suspected causes of or conditions associated with adverse (poor or excessive) fetal growth or preterm birth have been associated with oxidative stress. Plausibly, oxidative stress may be a common link underlying the superficial "programming" associations between adverse fetal growth or preterm birth and elevated risks of certain chronic diseases. The mechanisms of oxidative stress programming may be through directly modulating gene expression or indirectly through the effects of certain oxidized molecules. Experimental investigations have well demonstrated the rote of redox balance in modulating gene expression, and recent studies indicate that both the insulin functional axis and blood pressure could be sensitive targets to oxidative stress programming. Adverse programming may occur without affecting fetal growth, but more frequently among low birth weight infants merely because they more frequently experienced known or unknown conditions with oxidative insults. As oxidative stress levels are easily modifiable during pregnancy and early postnatal periods (which are plausible critical windows), the hypothesis, if proved valid, will suggest new measures that could be very helpful on fighting the increasing epidemic of the metabolic syndrome, type 2 diabetes and cardiovascular disease. Currently, there are several ongoing large randomized trials of antioxidant supplementation to counter oxidative stress during pregnancy for the prevention of preeclampsia. It would be invaluable if long-term follow-ups of infants born to women in such trials could be realized to test the oxidative stress programming hypothesis in such experimental trial settings. (c) 2005 Elsevier Ltd. All rights reserved.
C1 Univ Montreal, St Justine Hosp, Dept Obstet & Gynecol, Montreal, PQ H3T 1C5, Canada.
   Quebec Lipid Res Ctr, Laval, PQ, Canada.
   Univ Montreal, St Justine Hosp, Dept Pediat, Montreal, PQ, Canada.
   Queens Univ, Dept Obstet & Gynecol, Kingston, ON K7L 3N6, Canada.
   Tulane Univ, Dept Epidemiol, New Orleans, LA 70118 USA.
   Univ Ottawa, Dept Obstet & Gynecol, Ottawa, ON K1N 6N5, Canada.
C3 Universite de Montreal; Centre Hospitalier Universitaire Sainte-Justine;
   Universite de Montreal; Centre Hospitalier Universitaire Sainte-Justine;
   Queens University - Canada; Tulane University; University of Ottawa
RP Univ Montreal, St Justine Hosp, Dept Obstet & Gynecol, Room 4981,3175 Cote St Catherine, Montreal, PQ H3T 1C5, Canada.
EM zhong-cheng.luo@recherche-ste-justine.qc.ca
RI Luo, Zhong-Cheng/T-3882-2017; Audibert, François/AAL-1265-2020; Julien,
   Pierre/AGO-7542-2022; Smith, Graeme/ABB-6863-2021
OI Audibert, Francois/0000-0002-2697-3826; Smith,
   Graeme/0000-0002-3128-4523
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NR 50
TC 182
Z9 211
U1 1
U2 13
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0306-9877
EI 1532-2777
J9 MED HYPOTHESES
JI Med. Hypotheses
PY 2006
VL 66
IS 1
BP 38
EP 44
DI 10.1016/j.mehy.2005.08.020
PG 7
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 994MR
UT WOS:000234036400006
PM 16198060
DA 2025-06-11
ER

PT J
AU Courties, A
   Sellam, J
AF Courties, Alice
   Sellam, Jeremie
TI Osteoarthritis and type 2 diabetes mellitus: What are the links?
SO DIABETES RESEARCH AND CLINICAL PRACTICE
LA English
DT Review
DE Osteoarthritis; Metabolic syndrome; Diabetes mellitus; Oxidative stress;
   Glucose
ID GLYCATION END-PRODUCTS; HUMAN ARTICULAR CHONDROCYTES;
   NECROSIS-FACTOR-ALPHA; HIGH-FAT DIET; NF-KAPPA-B; HIGH GLUCOSE; HAND
   OSTEOARTHRITIS; KNEE OSTEOARTHRITIS; MESSENGER-RNA; UP-REGULATION
AB Osteoarthritis (OA) is the most frequent joint disorder and one of the leading cause of disability. During a long time, it was considered as the consequence of aging and mechanical stress on cartilage. Recent advances in the knowledge of OA have highlighted that it is a whole joint disease with early modifications of synovium and subchondral bone but also that it is associated with obesity and metabolic syndrome through systemic mechanisms. In the past year, type 2 diabetes has been described in two meta-analyzes as an independent risk factor for OA. In vivo models of diabetes corroborated epidemiological studies. Indeed, diabetic rodents display a spontaneous and a more severe experimental OA than their non-diabetic counterparts, which can be partially prevented by diabetes treatment (insulin, pioglitazone). The negative impact of diabetes on joints could be explain by the induction of oxidative stress and pro-inflammatory cytokines but also by advanced age products accumulation in joint tissues exposed to chronic high glucose concentration. Insulin resistance might also impair joint tissue because of a local insulin resistance of diabetic synovial membrane but also by the systemic low grade inflammation state related to obesity and insulin resistant state. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
C1 DHU i2B, St Antoine Hosp, AP HP, Dept Rheumatol, Paris, France.
   Univ Paris 06, Sorbonne Univ, DHU i2B, Inserm UMR S 938, Paris, France.
C3 Assistance Publique Hopitaux Paris (APHP); Sorbonne Universite; Hopital
   Universitaire Saint-Antoine - APHP; Institut National de la Sante et de
   la Recherche Medicale (Inserm); Sorbonne Universite
RP Sellam, J (corresponding author), Hop St Antoine, Serv Rhumatol, 184 Rue Faubourg St Antoine, F-75012 Paris, France.
EM Jeremie.sellam@aphp.fr
FU ROAD network (Fondation Arthritis Jacques Courtin); French Society of
   Rheumatology; Assistance Publique des Hopitaux de Paris (AP-HP)
FX The present work was supported by the ROAD network (Fondation Arthritis
   Jacques Courtin). A. Courties was supported by the French Society of
   Rheumatology and the Assistance Publique des Hopitaux de Paris (AP-HP).
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NR 72
TC 116
Z9 127
U1 0
U2 23
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0168-8227
EI 1872-8227
J9 DIABETES RES CLIN PR
JI Diabetes Res. Clin. Pract.
PD DEC
PY 2016
VL 122
BP 198
EP 206
DI 10.1016/j.diabres.2016.10.021
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA EF6TH
UT WOS:000390463200025
PM 27889689
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Coplan, JD
   Kolavennu, V
   Abdallah, CG
   Mathew, SJ
   Perera, TD
   Pantol, G
   Carpenter, D
   Tang, C
AF Coplan, Jeremy D.
   Kolavennu, Venu
   Abdallah, Chadi G.
   Mathew, Sanjay J.
   Perera, Tarique D.
   Pantol, Gustavo
   Carpenter, David
   Tang, Cheuk
TI Patterns of anterior versus posterior white matter fractional
   anistotropy concordance in adult nonhuman primates: Effects of early
   life stress
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
ID CORTICOTROPIN-RELEASING-FACTOR; CORPUS-CALLOSUM; GENERALIZED ANXIETY;
   METABOLIC SYNDROME; CHRONIC PAIN; CHILD-ABUSE; DIFFUSION; DEPRESSION;
   RILUZOLE; DISORDER
AB Introduction: Functional neuroimaging studies report global prefrontal dysconnectivity in mood disorders, supporting the notion of widespread disruptions in brain networks. Microscopic alterations in white matter (WM) tracts - which possess neuroplastic properties and play a central role in brain connectivity are interrogated herein in the context of brain dysconnectivity. Early life stress (ELS), an antecedent to human mood disorders, induces WM alterations in volumetrics and integrity. We hypothesized that nonhuman primate infants exposed to ELS would exhibit persistent impairments in both frontal and posterior concordance of WM integrity, therefore contributing to global brain dysconnectivity.
   Methods: Using a 3T MRI, diffusion tensor imaging (DTI) was performed on 21 adult male Bonnet macaques, 12 of whom had been raised under variable foraging demand (VFD) conditions and nine of whom had been raised under normative conditions (Non-VFD). As representative of anterior regions, fractional anisotropy (FA) concordance between anterior corpus callosum (ACorpusC) and anterior limb of the internal capsule (ALIC) was examined. For posterior regions, FA concordance between posterior corpus callosum (PCorpusC) and posterior limb of the internal capsule (PLICA) and between PCorpusC and occipital WM was examined. Examination of posterior FA was explored in the context of frontal markers of neuroplasticity.
   Results: A concordant relationship for FA between left ALIC and ACorpusC was evident in Non-VFD-reared subjects, but significantly absent in VFD-reared subjects. For left posterior regions, FA concordance between PLICA and PCorpusC and occipital WM and PCorpusC was evident in VFD-reared and not Non-VFDreared subjects. The posterior concordance in VFD was significantly distinguishable from the deficit in anterior concordance FA in VFD.
   Conclusions: The findings support the view that disrupted emotional integrity of the maternal-infant attachment process affects normative synchronous development of frontal white matter tracts but creates errant posterior concordance and also disrupts an inverse relationship between posterior white matter tracts and markers of neuroplasticity. We provide preliminary evidence that a concordant relationship between capsular-callosal FA may become discordant, providing a putative mechanism for prefrontal functional brain dysconnectivity. Published by Elsevier B.V.
C1 [Coplan, Jeremy D.] Suny Downstate Med Ctr, Dept Psychiat & Behav Sci, Brooklyn, NY 11203 USA.
   [Kolavennu, Venu] Yale Univ, Sch Med, Dept Psychiat, New Haven, CT USA.
   [Abdallah, Chadi G.] VA Natl Ctr PTSD, Clin Neurosci Div, West Haven, CT USA.
   [Mathew, Sanjay J.] Michael E Debakey VA Med Ctr, Mental Hlth Care Line, Houston, TX USA.
   [Perera, Tarique D.] Columbia Univ, Dept Psychiat, Coll Phys & Surg, New York State Psychiat Inst, New York, NY USA.
   [Pantol, Gustavo; Carpenter, David; Tang, Cheuk] Icahn Sch Med Mt Sinai, Dept Psychiat, New York, NY 10029 USA.
   [Pantol, Gustavo; Carpenter, David; Tang, Cheuk] Icahn Sch Med Mt Sinai, Dept Neurosci, New York, NY 10029 USA.
   [Pantol, Gustavo; Carpenter, David; Tang, Cheuk] Icahn Sch Med Mt Sinai, Dept Radiol, New York, NY 10029 USA.
   [Mathew, Sanjay J.] Baylor Coll Med, Menninger Dept Psychiat, Houston, TX 77030 USA.
C3 State University of New York (SUNY) System; SUNY Downstate Health
   Sciences University; Yale University; Baylor College of Medicine; Baylor
   College Medical Hospital; Columbia University; New York State Psychiatry
   Institute; Icahn School of Medicine at Mount Sinai; Icahn School of
   Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Baylor
   College of Medicine
RP Coplan, JD (corresponding author), Suny Downstate Med Ctr, Box 120,450 Clarkson Ave, Brooklyn, NY 11203 USA.
EM Jeremy.Coplan@Downstate.edu
RI Mathew, Sanjay/J-2830-2014; Abdallah, Chadi/M-9969-2017
OI Abdallah, Chadi/0000-0001-5783-6181
FU Pfizer Pharmaceuticals; GSK; Corcept; Neurocrine; Allergan; AstraZeneca;
   Bristol-Myers Squibb; Cephalon, Inc.; Johnson Johnson; Naurex; Noven;
   Roche; Takeda; National Institutes of Health (NIH)/National Institute of
   Mental Health (NIMH) [R01MH081870]; NIH National Center for Advancing
   Translational Sciences [UL1TR000067]; Department of Veterans Affairs;
   NARSAD Independent Investigator Award
FX Dr Coplan is a speaker for Pfizer, Forest, BMS, GSK, Eli Lilly and
   Sunovion. He has received grants from Pfizer Pharmaceuticals, GSK,
   Corcept and Neurocrine. He has served on the advisory board of Pfizer,
   Otsuka, Lundbeck and Corcept.Dr. Mathew has received consulting fees or
   research support from Allergan, AstraZeneca, Bristol-Myers Squibb,
   Cephalon, Inc., Corcept, Johnson & Johnson, Naurex, Noven, Roche, and
   Takeda. The ketamine research was supported by National Institutes of
   Health (NIH)/National Institute of Mental Health (NIMH) grant
   R01MH081870, UL1TR000067 from the NIH National Center for Advancing
   Translational Sciences, Department of Veterans Affairs, and a NARSAD
   Independent Investigator Award, and supported with resources and the use
   of facilities at the Michael E. DeBakey VA Medical Center, Houston, TX.
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NR 64
TC 8
Z9 8
U1 0
U2 16
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD MAR 1
PY 2016
VL 192
BP 167
EP 175
DI 10.1016/j.jad.2015.11.049
PG 9
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA DB8UG
UT WOS:000368791600024
PM 26735328
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Fiedorowicz, JG
   Solomon, DA
   Endicott, J
   Leon, AC
   Li, CS
   Rice, JP
   Coryell, WH
AF Fiedorowicz, Jess G.
   Solomon, David A.
   Endicott, Jean
   Leon, Andrew C.
   Li, Chunshan
   Rice, John P.
   Coryell, William H.
TI Manic/Hypomanic Symptom Burden and Cardiovascular Mortality in Bipolar
   Disorder
SO PSYCHOSOMATIC MEDICINE
LA English
DT Article
DE adult; bipolar disorder; cardiovascular mortality; mania; prospective
   cohort study; risk factors
ID METABOLIC SYNDROME; RISK-FACTORS; MYOCARDIAL-INFARCTION;
   DIABETES-MELLITUS; WEIGHT-GAIN; FOLLOW-UP; SCHIZOAFFECTIVE DISORDER;
   ATYPICAL ANTIPSYCHOTICS; PSYCHIATRIC-DISORDERS; DEPRESSED-PATIENTS
AB Objectives: To compare the risk for cardiovascular mortality between bipolar I and bipolar II subtypes and determine correlates of cardiovascular mortality. Bipolar disorder conveys an increased risk of cardiovascular mortality. Methods: Participants with major affective disorders were recruited for the National Institute of Mental Health Collaborative Depression Study and followed prospectively for up to 25 years. A total of 435 participants met the diagnostic criteria for bipolar I (n = 288) or bipolar II (n = 147) disorder based on Research Diagnostic Criteria at intake and measures of psychiatric symptoms during follow-up. Diagnostic subtypes were contrasted by cardiovascular mortality risk using Cox proportional hazards regression. Affective symptom burden (the proportion of time with clinically significant manic/hypomanic or depressive symptoms) and treatment exposure were additionally included in the models. Results: Thirty-three participants died from cardiovascular causes. Participants with bipolar I disorder had more than double the cardiovascular mortality risk of those with bipolar It disorder, after controlling for age and gender (hazard ratio = 2.35, 95% Confidence Interval = 1.04-5.33; p = .04). The observed difference in cardiovascular mortality between these subtypes was at least partially confounded by the burden of clinically significant manic/hypomanic symptoms which predicted cardiovascular mortality independent of diagnosis, treatment exposure, age, gender, and cardiovascular risk factors at intake. Selective serotonin uptake inhibitors seemed protective although they were introduced late in follow-up. Depressive symptom burden was not related to cardiovascular mortality. Conclusions: Participants with bipolar I disorder may face a greater risk of cardiovascular mortality than those with bipolar II disorder. This difference in cardiovascular mortality risk may reflect manic/hypomanic symptom burden.
C1 [Fiedorowicz, Jess G.; Coryell, William H.] Univ Iowa Hosp & Clin, Roy J & Lucille A Carver Coll Med, Dept Psychiat, Iowa City, IA 52242 USA.
   [Solomon, David A.] Brown Univ, Dept Psychiat & Human Behav, Warren Alpert Med Sch, Providence, RI 02912 USA.
   [Endicott, Jean] Columbia Univ, Coll Phys & Surg, Dept Psychiat, New York, NY USA.
   [Endicott, Jean] New York State Psychiat Inst & Hosp, New York, NY 10032 USA.
   [Leon, Andrew C.; Li, Chunshan] Cornell Univ, Weill Med Coll, Dept Psychiat, New York, NY 10021 USA.
   [Rice, John P.] Washington Univ, Sch Med, Dept Psychiat, St Louis, MO 63110 USA.
C3 University of Iowa; Brown University; Columbia University; New York
   State Psychiatry Institute; Cornell University; Weill Cornell Medicine;
   Washington University (WUSTL)
RP Fiedorowicz, JG (corresponding author), 200 Hawkins Dr W278GH, Iowa City, IA 52242 USA.
EM jess-fiedorowicz@uiowa.edu
RI Fiedorowicz, Jess/I-2512-2019
OI Fiedorowicz, Jess/0000-0003-2057-4071; coryell,
   william/0000-0003-3989-7276
FU National Institute of Mental Health [5R01MH025416, 5R01MH023864,
   5R01MH025478, 5R01MH025430, 5R01MH029957]; Nellie Ball Trust Research
   Fund; NARSAD Young Investigator Awar; Janserm Pharmaceutica; Abbott;
   Bristol-Meyers; Cyberonics; Intemeuron; Merck; Parkc-Davis; Pfizer;
   UpJohn; Wyeth-Ayerst;  [L30 MH075180]
FX This study was funded by Grant 5R01MH025416 to 33 (W.H.C.), Grant
   5R01MH023864 to 35 (J.E.), Grant 5R01MH025478 to 33 (M. Keller), Grant
   5R01MH025430 to 33 (J.P.R.), and Grant 5R01MH029957 to 30 (W.A.
   Scheftner) from the National Institute of Mental Health. Dr. Fiedorowicz
   is supported by Grant L30 MH075180 to 02, the Nellie Ball Trust Research
   Fund, and a NARSAD Young Investigator Award. He has also received
   research support for participating in a colleague's
   investigator-initiated study with Eli Lilly. Dr Solomon has served as an
   investigator for research funded by Janserm Pharmaceutica, as a
   consultant to Solvay Pharmaceuticals, Shire, and Novartis, and has
   served on the lecture bureaus of AstraZeneca, Pfizer, GlaxoSmithKline,
   and Shire. Dr. Endicott has received research support from Abbott,
   Bristol-Meyers, Cyberonics, Intemeuron, Merck, Parkc-Davis, Pfizer,
   UpJohn, and Wyeth-Ayerst; has served as a consultant or advisory board
   member for Abbott, AstraZeneca, Berlex, Bristol-Myers Squibb,
   Cyberonics, Eli Lilly, GlaxoSmithKIine, Novartis, Otsuka, Janssen,
   Ovation, Pfizer, Sanofi-Synthelabo Research, and Wyeth-Ayerst. Dr. Leon
   has served Data and Safety Monitoring Boards for Pfizer, Dainippon
   Sumitomo Pharma America, and Organon. He is a Consultant/Advisor to the
   Food and Drug Administration, NIMH, Cyberonics, and MedAvante. Dr. Rice
   is listed as an inventor on a patent (US 20070258898) held by Perlegen
   Sciences, covering the use of certain SNPs in determining the diagnosis,
   prognosis, and treatment of addiction. Mr. Li and Dr. Coryell have no
   disclosures or conflicts of interest to report.
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NR 87
TC 106
Z9 109
U1 2
U2 13
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0033-3174
J9 PSYCHOSOM MED
JI Psychosom. Med.
PD JUL-AUG
PY 2009
VL 71
IS 6
BP 598
EP 606
DI 10.1097/PSY.0b013e3181acee26
PG 9
WC Psychiatry; Psychology; Psychology, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry; Psychology
GA 471JA
UT WOS:000268052100002
PM 19561163
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Demir, B
   Demir, E
   Aciksari, G
   Uygun, T
   Utku, IK
   Gedikbasi, A
   Caglar, I
   Pirhan, O
   Tureli, HO
   Oflar, E
   Ungan, I
   Ciftci, S
   Karakaya, O
AF Demir, Bulent
   Demir, Esra
   Aciksari, Gonul
   Uygun, Turgut
   Utku, Irem Kirac
   Gedikbasi, Asuman
   Caglar, IlkerMurat
   Pirhan, Osman
   Tureli, Hande Oktay
   Oflar, Ersan
   Ungan, Ismail
   Ciftci, Serkan
   Karakaya, Osman
TI The Association between the Epicardial Adipose Tissue Thickness and
   Oxidative Stress Parameters in Isolated Metabolic Syndrome Patients: A
   Multimarker Approach
SO INTERNATIONAL JOURNAL OF ENDOCRINOLOGY
LA English
DT Article
ID SERUM PARAOXONASE; ARYLESTERASE ACTIVITIES; INSULIN-RESISTANCE; VISCERAL
   FAT; OBESITY; CHILDREN; DISEASE
AB The risk for cardiovascular diseases and type 2 diabetes mellitus significantly increases in the patient population with metabolic syndrome (MeS). The present study aimed to investigate the association between the epicardial adipose tissue thickness (EATT) and the oxidative stress parameters in MeS patients. The study included 181 patients as a patient group of 92 consecutive patients with MeS and a control group of 89 consecutive patients with similar age and gender. EATT was evaluated by transthoracic echocardiography. Serum levels of total oxidant status (TOS), total antioxidative capacity (TAS), paraoxonase-1 (PON-1), and arylesterase activities were measured. EATT was higher in the MeS group compared to the control group (6.0 +/- 2.0 mm and 4.0 +/- 1.0 mm, resp.; P < 0.001). The level of TOS was higher in the MeS group compared to the control group (P < 0.001). Additionally, the TAS level was higher in the MeS group compared to the control group (P < 0.001). Furthermore, the serum levels of PON-1 and arylesterase were lower in the MeS group compared to the control group (P < 0.001). EAT may cause an increased risk of cardiovascular diseases by leading to increased oxidative stress in patients with MeS.
C1 [Demir, Bulent; Uygun, Turgut; Caglar, IlkerMurat; Pirhan, Osman; Tureli, Hande Oktay; Oflar, Ersan; Ungan, Ismail; Ciftci, Serkan; Karakaya, Osman] Bakirkoy Dr Sadi Konuk Educ & Res Hosp, Dept Cardiol, TR-34156 Istanbul, Turkey.
   [Demir, Esra; Utku, Irem Kirac] Bakirkoy Dr Sadi Konuk Educ & Res Hosp, Dept Internal Med, TR-34156 Istanbul, Turkey.
   [Aciksari, Gonul] Istinye State Hosp, Dept Cardiol, Istanbul, Turkey.
   [Gedikbasi, Asuman] Bakirkoy Dr Sadi Konuk Educ & Res Hosp, Dept Biochem, TR-34156 Istanbul, Turkey.
C3 Bakirkoy Dr. Sadi Konuk Research & Training Hospital; Bakirkoy Dr. Sadi
   Konuk Research & Training Hospital; Istinye State Hospital; Bakirkoy Dr.
   Sadi Konuk Research & Training Hospital
RP Demir, B (corresponding author), Bakirkoy Dr Sadi Konuk Educ & Res Hosp, Dept Cardiol, Tevfik Saglam Caddesi 11, TR-34156 Istanbul, Turkey.
EM drbdmr06@hotmail.com
RI Gedikbasi, Asuman/AAE-3613-2020; Demir, Bulent/KVC-1688-2024; aciksari,
   gonul/LXW-1995-2024; Karakaya, Osman/KPB-5126-2024; kirac utku,
   irem/GPS-9145-2022; Pirhan, Osman/JAN-8491-2023
OI Aciksari, Gonul/0000-0002-8380-3065; Demir, Bulent/0000-0003-1767-408X
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NR 32
TC 16
Z9 19
U1 0
U2 6
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1687-8337
EI 1687-8345
J9 INT J ENDOCRINOL
JI Int. J. Endocrinol.
PY 2014
VL 2014
AR 954045
DI 10.1155/2014/954045
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA AT6EY
UT WOS:000345033100001
PM 25530760
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Vieira, TD
   Freitas, FV
   Neto, LCBS
   Borçoi, AR
   Mendes, SO
   Olinda, AS
   Moreno, IAA
   Quaioto, BR
   de Souza, MLM
   Barbosa, WM
   Arpini, JK
   Sorroche, BP
   Pinheiro, JD
   Archanjo, AB
   dos Santos, JG
   Arantes, LMRB
   de Oliveira, DR
   da Silva, AMA
AF Vieira, Tamires dos Santos
   Freitas, Flavia Vitorino
   Neto, Luiz Claudio Barreto Silva
   Borcoi, Aline Ribeiro
   Mendes, Suzanny Oliveira
   Olinda, Amanda Sgrancio
   Moreno, Ivana Alece Arantes
   Quaioto, Barbara Risse
   de Souza, Marcele Lorentz Mattos
   Barbosa, Wagner Miranda
   Arpini, Juliana Kruger
   Sorroche, Bruna Pereira
   Pinheiro, Julia de Assis
   Archanjo, Anderson Barros
   dos Santos, Joaquim Gasparini
   Arantes, Lidia Maria Rebolho Batista
   de Oliveira, Daniela Rodrigues
   da Silva, Adriana Madeira Alvares
TI An industrialized diet as a determinant of methylation in the 1F region
   of the NR3C1 gene promoter
SO FRONTIERS IN NUTRITION
LA English
DT Article
DE food consumption; lifestyle; metabolic stress; chronic diseases; diet's
   composition; epigenetic mechanisms; industrialized diet
ID GLUCOCORTICOID-RECEPTOR GENE; DEPRESSION INVENTORY-II; DNA METHYLATION;
   CHILDHOOD MALTREATMENT; METABOLIC SYNDROME; STRESS; PATTERNS; DISORDER;
   OBESITY; QUANTIFICATION
AB Background: Dietary composition can modify gene expression, favoring the development of chronic diseases via epigenetic mechanisms. Objective: Our study aimed to investigate the relationship between dietary patterns and NR3C1 gene methylation in users of the Brazilian Public Unified Health System (SUS). Methods: We recruited 250 adult volunteers and evaluated their socioeconomic status, psychosocial characteristics, lifestyle, and anthropometrics. Peripheral blood was collected and evaluated for cortisol levels, glycemia, lipid profile, and insulin resistance; methylation of CpGs 40-47 of the 1F region of the NR3C1 gene was also measured. Factors associated with degree of methylation were evaluated using generalized linear models (p < 0.05). Lifestyle variables and health variables were included as confounding factors. Results: The findings of our cross-sectional study indicated an association between NR3C1 DNA methylation and intake of processed foods. We also observed relevant associations of average NR3C1 DNA across the segment analyzed, methylation in component 1 (40-43), and methylation in component 2 (44-47) with a pattern of consumption of industrialized products in relation to BMI, serum cortisol levels, and lipid profile. These results may indicate a relationship between methylation and metabolic changes related to the stress response. Conclusion: These findings suggest an association of methylation and metabolic alterations with stress response. In addition, the present study highlights the significant role of diet quality as a stress-inducing factor that influences NR3C1 methylation. This relationship is further linked to changes in psychosocial factors, lifestyle choices, and cardiometabolic variables, including glucose levels, insulin resistance, and hyperlipidemia.
C1 [Vieira, Tamires dos Santos; Borcoi, Aline Ribeiro; Olinda, Amanda Sgrancio; Moreno, Ivana Alece Arantes; Quaioto, Barbara Risse; de Souza, Marcele Lorentz Mattos; Pinheiro, Julia de Assis; Archanjo, Anderson Barros; dos Santos, Joaquim Gasparini; da Silva, Adriana Madeira Alvares] Univ Fed Espirito Santo, Program Postgrad Biotechnol Renorbio, Vitoria, Brazil.
   [Freitas, Flavia Vitorino; Barbosa, Wagner Miranda] Univ Fed Espirito Santo, Dept Pharm & Nutr, Alegre, Brazil.
   [Neto, Luiz Claudio Barreto Silva] Univ Fed Espirito Santo, Program Postgrad Nutr & Hlth, Vitoria, Brazil.
   [Mendes, Suzanny Oliveira; da Silva, Adriana Madeira Alvares] Univ Fed Espirito Santo, Dept Morphol, Vitoria, Brazil.
   [Arpini, Juliana Kruger] Univ Fed Espirito Santo, Dept Biol, Alegre, Brazil.
   [Sorroche, Bruna Pereira; Arantes, Lidia Maria Rebolho Batista] Barretos Canc Hosp, Mol Oncol Res Ctr, Barretos, Brazil.
   [de Oliveira, Daniela Rodrigues] Coll Wisconsin, Dept Pharmacol & Med Toxicol, Milwaukee, WI USA.
C3 Universidade Federal do Espirito Santo; Universidade Federal do Espirito
   Santo; Universidade Federal do Espirito Santo; Universidade Federal do
   Espirito Santo; Universidade Federal do Espirito Santo; Hospital de
   Cancer de Barretos; Medical College of Wisconsin
RP Vieira, TD (corresponding author), Univ Fed Espirito Santo, Program Postgrad Biotechnol Renorbio, Vitoria, Brazil.
EM tamiresvieiraalim@gmail.com
RI Neto, Luiz/IWE-4412-2023; Álvares-da-Silva, Adriana/J-2912-2018;
   Sgrancio Olinda, Amanda/JXY-5673-2024; Quaioto, Bárbara/JCD-9609-2023;
   Archanjo, Anderson/Q-5245-2017; Borcoi, Aline/AAE-1281-2020; Pereira
   Sorroche, Bruna/ABA-2666-2020
OI Pereira Sorroche, Bruna/0000-0001-9802-8236
FU FAPES through the Research Programs of the Unified Health System - PPSUS
   [PPSUS 10/2013- 65883616/2014]; PPSUS [05/2015 - 59874713515/2016];
   FAPES/CNPq - PDCTR [11/2019- 557/2020]
FX This study received support from the Fundac & atilde;o de Amparo a
   Pesquisa e Inovac & atilde;o do Estado do Espirito Santo - FAPES through
   the Research Programs of the Unified Health System - PPSUS (PPSUS
   10/2013- 65883616/2014 and PPSUS 05/2015 - 59874713515/2016) and
   FAPES/CNPq - PDCTR (11/2019- 557/2020). We are grateful for the
   financial support provided by these organizations.r This study received
   support from the Fundac & atilde;o de Amparo a Pesquisa e Inovac &
   atilde;o do Estado do Espirito Santo - FAPES through the Research
   Programs of the Unified Health System - PPSUS (PPSUS 10/2013-
   65883616/2014 and PPSUS 05/2015 - 59874713515/2016) and FAPES/CNPq -
   PDCTR (11/2019- 557/2020). We are grateful for the financial support
   provided by these organizations.
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NR 82
TC 0
Z9 0
U1 1
U2 2
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD APR 3
PY 2024
VL 11
AR 1168715
DI 10.3389/fnut.2024.1168715
PG 17
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA NX9I5
UT WOS:001203866200001
PM 38633601
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Liu, JH
   Qian, YX
   Ma, QH
   Sun, HP
   Xu, Y
   Pan, CW
AF Liu, Jing-Hong
   Qian, Yu-Xi
   Ma, Qing-Hua
   Sun, Hong-Peng
   Xu, Yong
   Pan, Chen-Wei
TI Depressive symptoms and metabolic syndrome components among older
   Chinese adults
SO DIABETOLOGY & METABOLIC SYNDROME
LA English
DT Article
DE Depressive symptoms; Metabolic syndrome components; Public health;
   Epidemiology
ID QUALITY-OF-LIFE; BLOOD-PRESSURE; SEX; PREVALENCE; ANXIETY; RISK;
   ASSOCIATION; SEVERITY; DISORDER; SAMPLES
AB Background Few studies examined associations between depressive symptoms and metabolic syndrome (MetS) among older Chinese adults. Considering that the prevalence of depressive symptoms is high in older Chinese adults, we aimed to examine associations of depressive symptoms with MetS and its components in older Chinese adults. Methods Data from a community-based cross-sectional study of 4579 Chinese adults aged 60 years or older were analyzed. Depressive symptoms were assessed using the nine-item Patient Health Questionnaire. The presence of MetS was defined based on the Adult Treatment Panel III criteria, which include obesity, reduced blood high-density lipoprotein, high blood pressure (BP), elevated fasting plasma glucose and hypertriglyceridemia. A participant was considered as having MetS if he or she met at least three of the above-mentioned criteria. Results In all participants, depressive symptoms were related to elevated fasting plasma glucose (>= 7.0 mmol/L) (adjusted odds ratio [OR] = 1.50, 95% confidence interval [CI] [1.00-2.20]) and diabetes (adjusted OR = 1.50, 95% CI [1.01-2.20]). The associations of depressive symptoms with MetS and its components were not significant among women. However, there was a negative association between depressive symptoms and elevated systolic BP (>= 130 mm Hg) (OR = 0.59, 95% CI [0.4-0.9]), and similar findings were observed after adjusting for lifestyle-related variables in men. Conclusions In older Chinese adults, depressive symptoms were negatively associated with elevated systolic BP in men while these findings were not found in women.
C1 [Liu, Jing-Hong; Qian, Yu-Xi; Sun, Hong-Peng; Xu, Yong; Pan, Chen-Wei] Soochow Univ, Coll Med, Sch Publ Hlth, 199 Ren Ai Rd, Suzhou 215123, Peoples R China.
   [Ma, Qing-Hua] 3rd Peoples Hosp Xiangcheng Dist, Suzhou, Peoples R China.
C3 Soochow University - China
RP Pan, CW (corresponding author), Soochow Univ, Coll Med, Sch Publ Hlth, 199 Ren Ai Rd, Suzhou 215123, Peoples R China.
EM pcwonly@gmail.com
RI Ma, Qinghua/KPA-8692-2024; Pan, Chen-Wei/L-7174-2019; Sun,
   Hongpeng/JUF-6741-2023
OI Pan, Chen-Wei/0000-0003-3362-4613
FU Science and Technology Bureau of Xiangcheng District in Suzhou, China
   [XJ201706]; Health Commission of Suzhou [GSWS2019090]
FX This study was supported by the Science and Technology Bureau of
   Xiangcheng District in Suzhou, China under Grant No. XJ201706 and the
   Health Commission of Suzhou under Grant No. GSWS2019090.
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NR 43
TC 15
Z9 16
U1 0
U2 4
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1758-5996
J9 DIABETOL METAB SYNDR
JI Diabetol. Metab. Syndr.
PD FEB 18
PY 2020
VL 12
IS 1
AR 18
DI 10.1186/s13098-020-00526-2
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA KQ9HR
UT WOS:000517232300002
PM 32099584
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Jatana, S
   Abbadi, A
   Ponti, AK
   West, GA
   Braga-Neto, MB
   Smith, JL
   Marino-Melendez, A
   Willard, B
   Nagy, LE
   de la Motte, C
AF Jatana, Samreen
   Abbadi, Amina
   Ponti, Andras K.
   West, Gail A.
   Braga-Neto, Manuel B.
   Smith, Jordyn L.
   Marino-Melendez, Armando
   Willard, Belinda
   Nagy, Laura E.
   de la Motte, Carol
TI Hyperglycemic environments directly compromise intestinal epithelial
   barrier function in an organoid model and hyaluronan (∼35 kDa) protects
   via a layilin dependent mechanism
SO MATRIX BIOLOGY
LA English
DT Article
DE Hyperglycemia; Metabolic syndrome; Hyaluronan; Intestinal barrier;
   Organoids; Apoptosis; Layilin
ID IN-VITRO; HIGH GLUCOSE; STEM-CELLS; ZO-1; INFLAMMATION
AB Background: Metabolic syndrome and diabetes in obese individuals are strong risk factors for development of inflammatory bowel disease (IBD) and colorectal cancer. The pathogenic mechanisms of low-grade metabolic inflammation, including chronic hyperglycemic stress, in disrupting gut homeostasis are poorly understood. In this study, we sought to understand the impact of a hyperglycemic environment on intestinal barrier integrity and the protective effects of small molecular weight (35 kDa) hyaluronan on epithelial barrier function.
   Methods: Intestinal organoids derived from mouse colon were grown in normal glucose media (5 mM) or high glucose media (25 mM) to study the impact of hyperglycemic stress on the intestinal barrier. Additionally, organoids were pretreated with 35 kDa hyaluronan (HA35) to investigate the effect of hyaluronan on epithelial barrier under high glucose stress. Immunoblotting as well as confocal imaging was used to understand changes in barrier proteins, quantitative as well as spatial distribution, respectively. Alterations in barrier function were measured using trans-epithelial electrical resistance and fluorescein isothiocyanate flux assays. Untargeted proteomics analysis was performed to elucidate mechanisms by which HA35 exerts a protective effect on the barrier. Intestinal organoids derived from receptor knockout mice specific to various HA receptors were utilized to understand the role of HA receptors in barrier protection under high glucose conditions.
   Results: We found that high glucose stress decreased the protein expression as well as spatial distribution of two key barrier proteins, zona occludens-1 (ZO-1) and occludin. HA35 prevented the degradation or loss of ZO-1 and maintained the spatial distribution of both ZO-1 and occludin under hyperglycemic stress. Functionally, we also observed a protective effect of HA35 on the epithelial barrier under high glucose conditions. We found that HA receptor, layilin, was involved in preventing barrier protein loss (ZO-1) as well as maintaining spatial distribution of ZO-1 and occludin. Additionally, proteomics analysis showed that cell death and survival was the primary pathway upregulated in organoids treated with HA35 under high glucose stress. We found that XIAP associated factor 1 (Xaf1) was modulated by HA35 thereby regulating apoptotic cell death in the intestinal organoid system. Finally, we observed that spatial organization of both focal adhesion kinase (FAK) as well as Factin was mediated by HA35 via layilin.
   Conclusion: Our results highlight the impact of hyperglycemic stress on the intestinal barrier function. This is of clinical relevance, as impaired barrier function has been observed in individuals with metabolic syndrome. Additionally, we demonstrate barrier protective effects of HA35 through its receptor layilin and modulation of cellular apoptosis under high glucose stress.
C1 [Jatana, Samreen; Abbadi, Amina; West, Gail A.; Smith, Jordyn L.; Marino-Melendez, Armando; Nagy, Laura E.; de la Motte, Carol] Cleveland Clin, Lerner Res Inst, Dept Inflammat & Immun, Cleveland, OH USA.
   [Ponti, Andras K.] Cleveland Clin, Lerner Res Inst, Dept Cardiovasc & Metab Sci, Cleveland, OH USA.
   [Braga-Neto, Manuel B.] Cleveland Clin Fdn, Digest Dis & Surg Inst, Dept Gastroenterol Hepatol & Nutr, Cleveland, OH USA.
   [Willard, Belinda] Cleveland Clin, Lerner Res Inst, Proteom & Metab Core, Cleveland, OH USA.
   [Nagy, Laura E.] Cleveland Clin, Northern Ohio Alcohol Ctr, Dept Inflammat & Immun, Cleveland, OH USA.
   [Nagy, Laura E.; de la Motte, Carol] Cleveland Clin, Dept Gastroenterol & Hepatol, Cleveland, OH USA.
   [Nagy, Laura E.] Case Western Reserve Univ, Cleveland Clin, Lerner Coll Med, Dept Mol Med, Cleveland, OH USA.
C3 Cleveland Clinic Foundation; Cleveland Clinic Foundation; Cleveland
   Clinic Foundation; Cleveland Clinic Foundation; Cleveland Clinic
   Foundation; Cleveland Clinic Foundation; University System of Ohio; Case
   Western Reserve University; Cleveland Clinic Foundation
RP Jatana, S; de la Motte, C (corresponding author), Cleveland Clin, Lerner Res Inst, Cleveland, OH 44195 USA.
EM jatanas@ccf.org; delamoc@ccf.org
RI Nagarajan, Arun/HIZ-8452-2022
OI Jatana, Samreen/0000-0001-8255-7045; Braga Neto, Manuel
   B/0000-0001-8451-1753
FU National Institutes of Health (NIH) [R01AA023764]; Department of Defense
   (DOD) [PR190724/W81XWH2010235]; Crohn's and Colitis Foundation Research
   Fellowship Award [662997]; NIH Shared Instrumentation Grant
   [1S10OD019972-01, S10 OD030398]
FX This work was supported by National Institutes of Health (NIH) grant
   R01AA023764 and Department of Defense (DOD) grant PR190724/W81XWH2010235
   to LEN and CdlM. This study was also funded by the Crohn's and Colitis
   Foundation Research Fellowship Award (Award# 662997) to SJ. This work
   utilized the Leica SP8 confocal microscope that was purchased with from
   the NIH Shared Instrumentation Grant 1S10OD019972-01. The Bruker timsTof
   Pro2 instrument used for pro-teomics analysis was purchased via an NIH
   Shared Instrument Grant, S10 OD030398.
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NR 62
TC 3
Z9 3
U1 2
U2 8
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0945-053X
EI 1569-1802
J9 MATRIX BIOL
JI Matrix Biol.
PD NOV
PY 2024
VL 133
BP 116
EP 133
DI 10.1016/j.matbio.2024.08.007
EA SEP 2024
PG 18
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA Q7M8S
UT WOS:001386482200001
PM 39187208
OA hybrid
DA 2025-06-11
ER

PT J
AU Puustinen, PJ
   Koponen, H
   Kautiainen, H
   Mäntyselkä, P
   Vanhala, M
AF Puustinen, Pekka Johannes
   Koponen, Hannu
   Kautiainen, Hannu
   Mantyselka, Pekka
   Vanhala, Mauno
TI Psychological Distress Predicts the Development of the Metabolic
   Syndrome: A Prospective Population-Based Study
SO PSYCHOSOMATIC MEDICINE
LA English
DT Article
DE psychological distress; General Health Questionnaire; metabolic
   syndrome; health behaviors; C-reactive protein; inflammation
ID STRESSFUL LIFE EVENTS; C-REACTIVE PROTEIN; DEPRESSIVE SYMPTOMS;
   CARDIOVASCULAR-DISEASE; INSULIN-RESISTANCE; YOUNG-ADULTS; HEALTH; RISK;
   ANXIETY; INFLAMMATION
AB Objective: To examine prospectively the association of psychological distress with the development of the metabolic syndrome (MetS) and the potential influence of demographic characteristics, health behaviors, and inflammation in this association. Methods: A total of 466 (n = 185 males; 281 females) subjects, aged 36 to 56 years, and free of MetS at baseline, participated in a population-based study from 1997 to 1998 and again from 2004 to 2005. Mean observation time was 6.4 years. Various clinical, biochemical, and behavioral factors were measured at baseline, including assessment of psychological distress using the 12-item General Health Questionnaire. The development of MetS was measured at follow-up based on National Cholesterol Education Program criteria. Results: Subjects with high psychological distress at baseline (General Health Questionnaire scores, 4-12) were more than twice as likely to develop MetS than those with low psychological distress (odds ratio, 2.18; 95% confidence interval, 1.30-3.64). Adjustments for 1) age, gender, and sociodemographic variables; 2) health behaviors (smoking, alcohol use, and leisure time physical activity); and 3) C-reactive protein in the analysis diminished the odds of developing MetS in the distressed group (odds ratio, 1.87; 95% confidence interval, 1.83 and 1.81, respectively); however, the association remained statistically significant (p=.025-.038). Conclusions: Psychological distress at baseline increases the risk of developing MetS during follow-up. This association remained robust after adjusting for age, gender, sociodemographic variables, baseline health behaviors, and C-reactive protein. These prospective findings are evidence of a significant association between psychological distress and the development of MetS.
C1 [Puustinen, Pekka Johannes] Ctr Social & Hlth Serv, Kuopio 70101, Finland.
   [Mantyselka, Pekka] Univ Eastern Finland, Sch Med, Unit Primary Hlth Care, Kuopio, Finland.
   [Koponen, Hannu; Kautiainen, Hannu] Univ Eastern Finland, Dept Psychiat, Kuopio, Finland.
   Kuopio Univ Hosp, Unit Family Practice, SF-70210 Kuopio, Finland.
   [Koponen, Hannu; Kautiainen, Hannu; Vanhala, Mauno] Cent Hosp Middle Finland, Unit Family Practice, Jyvaskyla, Finland.
   ORTON, Rehabil Unit, Helsinki, Finland.
C3 University of Eastern Finland; University of Eastern Finland; Kuopio
   University Hospital; University of Eastern Finland; University of
   Eastern Finland Hospital; Central Finland Central Hospital
RP Puustinen, PJ (corresponding author), Ctr Social & Hlth Serv, PL 227, Kuopio 70101, Finland.
EM puustinenpekka@hotmail.com
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NR 51
TC 56
Z9 65
U1 0
U2 12
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0033-3174
EI 1534-7796
J9 PSYCHOSOM MED
JI Psychosom. Med.
PD FEB-MAR
PY 2011
VL 73
IS 2
BP 158
EP 165
DI 10.1097/PSY.0b013e3182037315
PG 8
WC Psychiatry; Psychology; Psychology, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry; Psychology
GA 725QY
UT WOS:000287662200006
PM 21148808
DA 2025-06-11
ER

PT J
AU McGrath-Morrow, SA
   Collaco, JM
   Crawford, TO
   Carson, KA
   Lefton-Greif, MA
   Zeitlin, P
   Lederman, HM
AF McGrath-Morrow, Sharon A.
   Collaco, J. Michael
   Crawford, Thomas O.
   Carson, Kathryn A.
   Lefton-Greif, Maureen A.
   Zeitlin, Pamela
   Lederman, Howard M.
TI Elevated Serum IL-8 Levels in Ataxia Telangiectasia
SO JOURNAL OF PEDIATRICS
LA English
DT Article
ID METABOLIC SYNDROME; ATM; STRESS; GENE
AB Serum interleukin (IL)-8 levels were measured in 50 patients with ataxia telangiectasia (A-T) and 22 without A-T. In a cross-sectional study, the geometric mean of IL-8 level was significantly higher in the patients with A-T (P <. 0001). Elevated serum IL-8 levels in patients with A-T suggest that systemic inflammation may contribute to the disease phenotype. (J Pediatr 2010; 156: 682-4)
C1 [McGrath-Morrow, Sharon A.] Johns Hopkins Med Inst, Dept Pediat, Div Pediat Pulmonol, Baltimore, MD 21287 USA.
   [Lederman, Howard M.] Johns Hopkins Med Inst, Div Pediat Allergy & Immunol, Baltimore, MD 21287 USA.
   [Crawford, Thomas O.] Johns Hopkins Med Inst, Dept Neurol, Baltimore, MD 21287 USA.
   [Carson, Kathryn A.] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA.
C3 Johns Hopkins University; Johns Hopkins Medicine; Johns Hopkins
   University; Johns Hopkins Medicine; Johns Hopkins University; Johns
   Hopkins Medicine; Johns Hopkins University; Johns Hopkins Bloomberg
   School of Public Health
RP McGrath-Morrow, SA (corresponding author), Johns Hopkins Med Inst, Dept Pediat, Div Pediat Pulmonol, Suite 3029,200 N Wolfe St, Baltimore, MD 21287 USA.
EM smorrow@jhmi.edu
RI McGrath-Morrow, Sharon/JMC-0464-2023; Crawford, Thomas/E-6307-2012
OI Zeitlin, Pamela/0000-0002-2719-1834
FU National Center for Research Resources, a component of the National
   Institutes of Health (NIH); NIH Roadmap for Medical Research [UL1RR
   025005]; Johns Hopkins Hospital Pediatric Clinical Research Center [UL1
   RR 025005]
FX Supported by the AT Children's Project, National Center for Research
   Resources, a component of the National Institutes of Health (NIH); NIH
   Roadmap for Medical Research Grant UL1RR 025005 (to K. C.); and Johns
   Hopkins Hospital Pediatric Clinical Research Center Grant UL1 RR 025005
   (to S. M.- M., T. C., P. Z., and H. L.). The authors declare no
   conflicts of interest.
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NR 11
TC 38
Z9 40
U1 0
U2 1
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0022-3476
J9 J PEDIATR-US
JI J. Pediatr.
PD APR
PY 2010
VL 156
IS 4
BP 682
EP U213
DI 10.1016/j.jpeds.2009.12.007
PG 4
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA 572CR
UT WOS:000275805000032
PM 20171651
DA 2025-06-11
ER

PT J
AU Perrone, MG
   Santandrea, E
   Bleve, L
   Vitale, P
   Colabufo, NA
   Jockers, R
   Milazzo, FM
   Sciarroni, AF
   Scilimati, A
AF Perrone, Maria Grazia
   Santandrea, Ernesto
   Bleve, Laura
   Vitale, Paola
   Colabufo, Nicola Antonio
   Jockers, Ralf
   Milazzo, Ferdinando Maria
   Sciarroni, Anna Floriana
   Scilimati, Antonio
TI Stereospecific synthesis and bio-activity of novel
   β3-adrenoceptor agonists and inverse agonists
SO BIOORGANIC & MEDICINAL CHEMISTRY
LA English
DT Article
DE agonist; inverse agonist; beta(3)-adrenoceptor; (alpha S : beta S)- and
   (alpha S : beta R)-2-{4-[2-(2-hydroxy-2
   phenylethylamino)ethyl]phenoxy}propanoic acid; obesity; type 2 diabetes;
   heart failure; cachexia; metabolic syndrome; overactive bladder; preterm
   labour; anxiety and depressive disorders; DELFIA
ID BETA(3) ADRENERGIC-RECEPTOR; CARBOXYL-PROMOTED ENHANCEMENT; FREQUENT
   URINATION; PHARMACOLOGICAL CHARACTERIZATION; PART 1; POTENT; DISCOVERY;
   IDENTIFICATION; ADRENOCEPTOR; DERIVATIVES
AB Since it is widely distributed into the body, beta(3)-adrenoceptor is becoming an attractive target for the treatment of several pathologies such as obesity, type 2 diabetes, metabolic syndrome, cachexia, overactive bladder, ulcero-inflammatory disorder of the gut, preterm labour, anxiety and depressive disorders, and heart failure. New compounds belonging to the class of arylethanolamines bearing one or two stereogenic centres were prepared in good yields as racemates and optically active forms. They were, then, evaluated for their intrinsic activity towards beta(3)-adrenoceptor and their affinity for beta(1)- and beta(2)-adrenergic receptors. Stereochemical features were found to play a crucial role in determining the behaviour of such compounds. In particular, alpha-racemic, (alpha R)- and (alpha S)2-14-[2-(2-hydroxy-2-phenylethylamino)ethyl]phenoxy)-2- methylpropanoic acid, (alpha-rac, beta-rac)-, (alpha R, beta S)- and (alpha R, beta R)- 2- 4-[2-(2-hydroxy-2-phenylethylamino)ethyl]phenoxylpropanoic acid were found to be endowed with beta(3)-adrenoceptor agonistic activity. Whereas, (alpha S, beta S)- and (alpha S, beta R)-2-14-[2-(2-hydroxy-2-phenylethylamino)ethyl]phenoxy propanoic acid behaved as beta(3)-adrenoceptor inverse agonists. Such compounds showed no affinity for beta(1)- and beta(2)-adrenergic receptor, respectively. Thus, resulting highly selective beta(3)-adrenoceptor ligands. (C) 2007 Elsevier Ltd. All rights reserved.
C1 [Perrone, Maria Grazia; Santandrea, Ernesto; Bleve, Laura; Vitale, Paola; Colabufo, Nicola Antonio; Scilimati, Antonio] Univ Bari, Dept Farmacochim, I-70125 Bari, Italy.
   [Jockers, Ralf] Univ Paris, CNRS 8104, Inst Cochin Inserm U567, F-75014 Paris, France.
   [Milazzo, Ferdinando Maria; Sciarroni, Anna Floriana] Sigma Tau Pharmaceut Co, Dipartimento Endocrinol & Metabolismo, I-00040 Pomezia, Italy.
C3 Universita degli Studi di Bari Aldo Moro; Centre National de la
   Recherche Scientifique (CNRS); Institut National de la Sante et de la
   Recherche Medicale (Inserm); Universite Paris Cite; Leadiant Biosciences
RP Scilimati, A (corresponding author), Univ Bari, Dept Farmacochim, Via E Orabona 4, I-70125 Bari, Italy.
EM ascilimati@farmchim.uniba.it
RI Jockers, Ralf/Q-2100-2019; vitale, paola/A-3370-2014
OI vitale, paola/0000-0001-8132-2893; Scilimati,
   Antonio/0000-0003-2740-6425; Perrone, Maria Grazia/0000-0003-4195-5228
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NR 53
TC 21
Z9 23
U1 0
U2 4
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0968-0896
EI 1464-3391
J9 BIOORGAN MED CHEM
JI Bioorg. Med. Chem.
PD MAR 1
PY 2008
VL 16
IS 5
BP 2473
EP 2488
DI 10.1016/j.bmc.2007.11.060
PG 16
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Chemistry,
   Organic
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Chemistry
GA 288RB
UT WOS:000255002400028
PM 18083578
DA 2025-06-11
ER

PT J
AU Li, AH
   Lee, BC
   Chen, KC
   Weng, CS
   Chu, SH
AF Li, Ai-Hsien
   Lee, Bai-Chin
   Chen, Kuo-Chin
   Weng, Ching-Sung
   Chu, Shu-Hsun
TI Brachial Artery Flow-Mediated Vasodilation in Patients With Cardiac
   Syndrome X
SO ANGIOLOGY
LA English
DT Article
DE cardiac syndrome X; endothelium; flow-mediated vasodilatation;
   endothelin-1
ID NORMAL CORONARY ARTERIOGRAMS; ENDOTHELIAL DYSFUNCTION; CHEST-PAIN;
   MYOCARDIAL-PERFUSION; ANGINA-PECTORIS; DISEASE; DILATION; ANGIOGRAMS;
   THICKNESS
AB Cardiac syndrome X (CSX) differs from coronary artery disease (CAD) and is characterized by angina, positive stress test, and patent coronary arteries. The probable mechanism is a microvascular disorder associated with endothelial dysfunction. In this study, brachial artery flow-mediated vasodilation was used as well as the endothelin-1 assay to assess endothelial function in patients with cardiac syndrome X (CSX), coronary artery disease (CAD), and healthy controls. All subjects underwent a 2-step brachial artery flow-related vasodilatation test. Serum endothelin-1, one of the most potent constricting factors, was measured for all participants. Patients with CSX had a lower brachial artery dilation ratio than controls but higher than that of CAD patients. Control subjects and CSX patients had higher endothelin-1 levels than CAD patients. CSX patients were found to have worse endothelial function than health), volunteers, but patients with CAD had even worse endothelium function than CSX patients.
C1 [Li, Ai-Hsien; Weng, Ching-Sung] Chung Yuan Christian Univ, Dept Biomed Engn, Chungli, Taiwan.
   [Li, Ai-Hsien; Lee, Bai-Chin] Natl Taiwan Univ Hosp, Dept Internal Med, Taipei 100, Taiwan.
   [Li, Ai-Hsien; Chen, Kuo-Chin; Chu, Shu-Hsun] Far Eastern Mem Hosp, Ctr Cardiovasc, Taipei, Taiwan.
C3 Chung Yuan Christian University; National Taiwan University; National
   Taiwan University Hospital; Far Eastern Memorial Hospital
RP Weng, CS (corresponding author), 200 Chung Pei Rd, Chungli, Taiwan.
EM las1012.tw@yahoo.com.tw
RI Lee, Chien-Chang/HHM-5986-2022
OI LEE, BAI-CHIN/0000-0002-7381-4318; Chu, Shu-Hsun/0000-0001-9652-3604
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NR 22
TC 5
Z9 5
U1 0
U2 0
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0003-3197
EI 1940-1574
J9 ANGIOLOGY
JI Angiology
PD OCT-NOV
PY 2008
VL 59
IS 5
BP 581
EP 586
DI 10.1177/0003319707308032
PG 6
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 366LR
UT WOS:000260483500008
PM 18388101
DA 2025-06-11
ER

PT J
AU Nagasawa, K
   Matsuura, N
   Takeshita, Y
   Ito, S
   Sano, Y
   Yamada, Y
   Uchinaka, A
   Murohara, T
   Nagata, K
AF Nagasawa, K.
   Matsuura, N.
   Takeshita, Y.
   Ito, S.
   Sano, Y.
   Yamada, Y.
   Uchinaka, A.
   Murohara, T.
   Nagata, K.
TI Attenuation of cold stress-induced exacerbation of cardiac and adipose
   tissue pathology and metabolic disorders in a rat model of metabolic
   syndrome by the glucocorticoid receptor antagonist RU486
SO NUTRITION & DIABETES
LA English
DT Article
ID 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1; NECROSIS-FACTOR-ALPHA;
   DIASTOLIC DYSFUNCTION; INDUCED HYPERTENSION; HEART-FAILURE; CORTISOL
   SECRETION; NEUROPEPTIDE-Y; BLOOD-PRESSURE; ANIMAL-MODEL; OBESITY
AB OBJECTIVES: Chronic stress affects the central nervous system as well as endocrine, metabolic and immune systems. However, the effects of cold stress on cardiovascular and metabolic disorders in metabolic syndrome (MetS) have remained unclear. We recently characterized DahlS.Z-Lepr(fa)/Lepr(fa) (DS/obese) rats, derived from a cross between Dahl salt-sensitive and Zucker rats, as a new animal model of MetS. We have now investigated the effects of chronic cold stress and glucocorticoid receptor (GR) blockade on cardiac and adipose tissue pathology as well as on metabolic parameters in this model.
   METHODS: DS/obese rats were exposed to cold stress (immersion in ice-cold water to a depth of 1-2 cm for 2 h per day) with or without subcutaneous injection of the GR antagonist RU486 (2 mg kg(-1) day(-1)) for 4 weeks beginning at 9 weeks of age. Age-matched homozygous lean (DahlS.Z-Lepr(+)/Lepr(+)) littermates served as a control.
   RESULTS: Chronic cold stress exacerbated hypertension as well as left ventricular (LV) hypertrophy, fibrosis and diastolic dysfunction in DS/obese rats in a manner sensitive to RU486 treatment. Cold stress with or without RU486 did not affect body weight or fat mass. In contrast, cold stress further increased cardiac oxidative stress as well as macrophage infiltration and proinflammatory gene expression in LV and visceral fat tissue, with all of these effects being attenuated by RU486. Cold stress also further increased GR and 11 beta-hydroxysteroid dehydrogenase type 1 mRNA and protein abundance in LV and visceral adipose tissue, and these effects were again inhibited by RU486. In addition, RU486 ameliorated the stress-induced aggravation of dyslipidemia, glucose intolerance and insulin resistance in DS/obese rats.
   CONCLUSIONS: Our results implicate GR signaling in cold stress-induced exacerbation of cardiac and adipose tissue pathology as well as of abnormal glucose and lipid metabolism in a rat model of MetS.
C1 [Nagasawa, K.; Matsuura, N.; Takeshita, Y.; Ito, S.; Sano, Y.; Yamada, Y.; Uchinaka, A.; Nagata, K.] Dept Pathophysiol Lab Sci, Nagoya, Aichi, Japan.
   [Murohara, T.] Nagoya Univ, Grad Sch Med, Dept Cardiol, Nagoya, Aichi 4648601, Japan.
C3 Nagoya University
RP Nagata, K (corresponding author), Nagoya Univ, Grad Sch Med, Dept Pathophysiol Lab Sci, Higashi Ku, 1-1-20 Daikominami, Nagoya, Aichi 4618673, Japan.
EM nagata@met.nagoya-u.ac.jp
RI Murohara, Toyoaki/M-4958-2014
FU Ministry of Education, Culture, Sports, Science, and Technology of Japan
   [24590690]; Grants-in-Aid for Scientific Research [24590690] Funding
   Source: KAKEN
FX We thank Dr Shogo Watanabe for technical assistance. This work was
   supported by a grant from the Ministry of Education, Culture, Sports,
   Science, and Technology of Japan (no. 24590690 to KN).
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NR 51
TC 14
Z9 17
U1 5
U2 15
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 2044-4052
J9 NUTR DIABETES
JI Nutr. Diabetes
PD APR 25
PY 2016
VL 6
AR e207
DI 10.1038/nutd.2016.14
PG 9
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA DK2IO
UT WOS:000374738100004
PM 27110688
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Sone, H
   Horikawa, C
   Tanaka-Mizuno, S
   Kawasaki, R
   Fujihara, K
   Moriya, T
   Araki, A
   Tanaka, S
   Akanuma, Y
AF Sone, Hirohito
   Horikawa, Chika
   Tanaka-Mizuno, Sachiko
   Kawasaki, Ryo
   Fujihara, Kazuya
   Moriya, Tatsumi
   Araki, Atsushi
   Tanaka, Shiro
   Akanuma, Yasuo
TI Japan Diabetes Complications Study: Revisiting one of the first
   large-scale clinical studies in East Asians with diabetes
SO JOURNAL OF DIABETES INVESTIGATION
LA English
DT Review; Early Access
DE East Asia; large-scale clinical study; Lifestyle
ID CORONARY-HEART-DISEASE; RENAL-FUNCTION DECLINE; ALL-CAUSE MORTALITY;
   CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; PHYSICAL-ACTIVITY;
   RISK-FACTOR; TYPE-2; RETINOPATHY; PREDICTOR
AB This review highlights the significance of the Japan Diabetes Complications Study (JDCS), one of the earliest large-scale studies of people with type 2 diabetes outside Europe and the United States, in understanding type 2 diabetes mellitus among East Asian populations, particularly in Japan. Historically, large-scale clinical studies on type 2 diabetes mellitus have predominantly focused on Western populations, despite East Asians comprising the largest proportion of diabetic patients globally. The JDCS, which was initiated in 1996, enrolled 2,033 Japanese type 2 diabetes mellitus patients. It aimed to evaluate the effects of intensive lifestyle interventions on diabetic complications. The study demonstrated that lifestyle-focused interventions significantly reduced the risk of stroke and other complications compared to conventional treatment. Key findings of its sub-analyses include the unique characteristics of Japanese patients with type 2 diabetes mellitus, such as their lower body mass index (BMI) compared to Western counterparts and a stronger association between even modest BMI increases and beta cell dysfunction. Additionally, the JDCS provided insights into the risk factors for nephropathy, retinopathy, and macrovascular complications, emphasizing the importance of controlling blood pressure, glycemia, and lifestyle factors. The study also explored the impact of diet, exercise, and mental health on diabetic outcomes, revealing the protective effects of physical activity and a balanced diet, while highlighting the risks associated with high salt intake and depression. A risk prediction model tailored to Japanese patients was also developed. Overall, this study made a significant contribution to the evidence-based management of type 2 diabetes mellitus in East Asia.
C1 [Sone, Hirohito; Fujihara, Kazuya] Niigata Univ, Fac Med, Dept Hematol Endocrinol & Metab, Niigata, Japan.
   [Horikawa, Chika] Univ Niigata Prefecture, Fac Human Life Studies, Dept Hlth & Nutr, Niigata, Japan.
   [Tanaka-Mizuno, Sachiko] Kobe Pharmaceut Univ, Lab Epidemiol & Prevent, Kobe, Japan.
   [Kawasaki, Ryo] Osaka Univ, Grad Sch Med, Dept Social Med, Div Publ Hlth, Osaka, Japan.
   [Moriya, Tatsumi] Kitasato Univ, Hlth Care Ctr, Sagamihara, Japan.
   [Araki, Atsushi] Tokyo Metropolitan Inst Geriatr & Gerontol, Dept Diabet Metab & Endocrinol, Tokyo, Japan.
   [Tanaka, Shiro] Kyoto Univ, Grad Sch Med, Dept Clin Biostat, Kyoto, Japan.
   [Akanuma, Yasuo] Asahi Life Fdn, Inst Med Sci, Tokyo, Japan.
C3 Niigata University; University Niigata Prefecture; Kobe Pharmaceutical
   University; The University of Osaka; Kitasato University; Kyoto
   University; Asahi Life Foundation
RP Sone, H (corresponding author), Niigata Univ, Fac Med, Dept Hematol Endocrinol & Metab, Niigata, Japan.
EM sone@med.niigata-u.ac.jp
RI Horikawa, Chika/MBG-7140-2025; Kawasaki, Ryo/B-8859-2015; Araki,
   Atsushi/JVE-0081-2024; 田中, 司朗/GON-6916-2022; Sone,
   Hirohito/ABC-9346-2021
OI Sone, Hirohito/0000-0003-1263-2817; Fujihara, Kazuya/0000-0001-6725-4169
FU The Japan Society for the Promotion of Science; Ministry of Health,
   Labour and Welfare of Japan; Japan Society for the Promotion of Science
FX We would like to express our sincere gratitude and condolences to the
   late Prof. Nobuhiro Yamada and the late Prof. Yasuo Ohashi, who were
   founding members of the JDCS. In addition, we would like to express our
   deepest gratitude to the many study group members and participants who
   cooperated with the JDCS, including Prof. Satoshi Iimuro
   (biostatistics), Prof. Shun Ishibashi (macroangiopathy), Prof. Shigehiro
   Katayama (nephropathy), Prof. Hidetoshi Yamashita (retinopathy), and
   Prof. Yukio Yoshimura (nutritional therapy). The JDCS was financially
   supported by the Ministry of Health, Labour and Welfare of Japan and the
   Japan Society for the Promotion of Science.
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NR 43
TC 0
Z9 0
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2040-1116
EI 2040-1124
J9 J DIABETES INVEST
JI J. Diabetes Investig.
PD 2024 DEC 24
PY 2024
DI 10.1111/jdi.14394
EA DEC 2024
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA Q0W3Z
UT WOS:001381993700001
PM 39716905
OA gold
DA 2025-06-11
ER

PT J
AU Veru-Lesmes, F
   Rho, A
   King, S
   Joober, R
   Pruessner, M
   Malla, A
   Iyer, SN
AF Veru-Lesmes, Franz
   Rho, Aldanie
   King, Suzanne
   Joober, Ridha
   Pruessner, Marita
   Malla, Ashok
   Iyer, Srividya N.
TI Social Determinants of Health and Preclinical Glycemic Control in Newly
   Diagnosed First-Episode Psychosis Patients
SO CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE
LA English
DT Article
DE first episode psychosis; social determinants; biopsychosocial; child
   maltreatment; race; immigrant mental health; income inequality
ID BODY-MASS INDEX; CHILDHOOD TRAUMA; INSULIN-RESISTANCE; METABOLIC
   SYNDROME; ETHNIC-GROUPS; OBESITY; SCHIZOPHRENIA; METAANALYSIS; RISK;
   ASSOCIATIONS
AB Background: The abnormally high incidence of disorders of glucose metabolism (DGM) in psychotic-spectrum disorders (PSD) has often been attributed to the side effects of antipsychotics and unhealthy lifestyles. The influence of social determinants of health has been largely ignored, despite ample evidence linking social adversity with both PSD and DGM. The aim of this study is to examine the influence of well-established social determinants of health on preclinical levels of glycated hemoglobin (HbA1c) in a sample of first-episode psychosis (FEP) patients.
   Methods: In a sample of newly admitted FEP patients, univariate analyses were used to select the main predictors of HbA1c levels from the following social determinants of health: childhood trauma, immigrant background, visible minority status, and indices of social and material deprivation. The predictors identified in the univariate analyses were tested in multivariate linear regression models including age, sex, BMI, depression, and physical anergia (proxy of sedentary behaviour) as covariates.
   Results: Univariate analyses identified visible minority status and childhood physical abuse as predictors of HbA1c. After controlling for covariates, minority status significantly predicted higher levels of glycated hemoglobin ( = 0.23; P = 0.01), and physical abuse had a marginally significant effect ( = 0.23; P = 0.06). Other predictors were not significantly associated.
   Conclusion: FEP patients from a visible minority or who were victims of childhood physical abuse have higher levels of HbA1c at admission compared with other patients. This might suggest an increase in risk for the development of future DGM. If confirmed, preventive strategies could be tailored for these groups.
C1 [Veru-Lesmes, Franz; Rho, Aldanie; Joober, Ridha; Pruessner, Marita; Malla, Ashok; Iyer, Srividya N.] Prevent & Early Intervent Program Psychosis, Montreal, PQ, Canada.
   [Veru-Lesmes, Franz; Rho, Aldanie; King, Suzanne; Joober, Ridha; Pruessner, Marita; Malla, Ashok; Iyer, Srividya N.] Douglas Mental Hlth Univ Inst, 6875 LaSalle Blvd, Montreal, PQ H4H 1R3, Canada.
   [Veru-Lesmes, Franz; King, Suzanne; Joober, Ridha; Pruessner, Marita; Malla, Ashok; Iyer, Srividya N.] McGill Univ, Dept Psychiat, Montreal, PQ, Canada.
   [Pruessner, Marita] Univ Konstanz, Dept Psychol, Constance, Germany.
C3 McGill University; University of Konstanz
RP Iyer, SN (corresponding author), Douglas Mental Hlth Univ Inst, 6875 LaSalle Blvd, Montreal, PQ H4H 1R3, Canada.
EM srividya.iyer@mcgill.ca
RI King, Suzanne/AAM-8541-2020; Iyer, Srividya/AAU-2256-2021
OI Iyer, Srividya/0000-0001-5367-9086; Rho, Aldanie/0000-0001-8063-6655
FU Canadian Institutes of Health Research; National Institute of Mental
   Health [MH093303]; Fonds de recherche du Quebec - Sante; Canada Research
   Chairs Program; Fonds de recherche du Quebec-Sante; Schizophrenia
   Society of Canada Foundation; Canadian College of
   Neuropsychopharmacology
FX The authors disclosed receipt of the following financial support for the
   research, authorship, and/or publication of this article: The present
   project was funded by operating grants from the Canadian Institutes of
   Health Research and the National Institute of Mental Health (MH093303).
   Dr. S.N. Iyer has received salary awards from the Fonds de recherche du
   Quebec - Sante and from the Canadian Institutes of Health Research. Dr.
   A. Malla is supported by the Canada Research Chairs Program. Dr. R.
   Joober has received salary awards from the Fonds de recherche du Quebec
   - Sante. Dr. F. Veru-Lesmes is supported through a doctoral training
   award granted by the Fonds de recherche du Quebec-Sante, and a doctoral
   studentship from the Schizophrenia Society of Canada Foundation and
   Canadian College of Neuropsychopharmacology.
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NR 60
TC 15
Z9 15
U1 0
U2 14
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0706-7437
EI 1497-0015
J9 CAN J PSYCHIAT
JI Can. J. Psychiat.-Rev. Can. Psychiat.
PD AUG
PY 2018
VL 63
IS 8
BP 547
EP 556
DI 10.1177/0706743718762097
PG 10
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA GQ0DX
UT WOS:000441288000006
PM 29661027
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Mourtzi, N
   Yannakoulia, M
   Ntanasi, E
   Kosmidis, MH
   Anastasiou, CA
   Dardiotis, E
   Hadjigeorgiou, G
   Megalou, M
   Sakka, P
   Scarmeas, N
AF Mourtzi, N.
   Yannakoulia, M.
   Ntanasi, E.
   Kosmidis, M. H.
   Anastasiou, C. A.
   Dardiotis, E.
   Hadjigeorgiou, G.
   Megalou, M.
   Sakka, P.
   Scarmeas, N.
TI History of induced abortions and frailty in older Greek women: results
   from the HELIAD study
SO EUROPEAN GERIATRIC MEDICINE
LA English
DT Article
DE Frailty; Abortions; Women; Greece
ID GERIATRIC DEPRESSION SCALE; METABOLIC SYNDROME; RHEUMATOID-ARTHRITIS;
   INSULIN-RESISTANCE; CHINESE WOMEN; MENTAL-HEALTH; ADULTS;
   MICROCHIMERISM; ASSOCIATION; RISK
AB Purpose Women are almost twice as likely as men to develop frailty and early-traumatic experiences related to reproduction may have a role to play. The purpose of this study was to investigate the association between a history of induced abortions and risk of frailty.
   Methods 1062 women aged >= 65 years from the HELIAD study were included in the present cross-sectional study. Frailty was assessed by frailty index and Fried definitions. The history of abortion and of other reproductive experiences (age onset of menstruation, age of menopause, number of offspring, and number of miscarriages) was obtained by all participants. Logistic and linear regression analyses were performed to examine whether the number of abortions was related to frailty.
   Results When frailty was defined with frailty index, women with 1 or 2 abortions had 1.7 higher risk of frailty compared to women with no history of abortions, while those with more than 3 abortions had more than a twofold higher risk of frailty. Two supplementary analyses excluding women with surgical operations' history and women with dementia revealed similar results. When frailty was defined with Fried definition, the analysis was marginally significant when abortion was inserted as a categorical variable. Women with more than 3 abortions showed 2.4 higher risk of frailty compared to women with no history of abortion.
   Conclusion The number of induced abortions was associated with moderate higher odds of frailty, when frailty was defined according to frailty index. A similar trend was revealed in the model with Fried definition after trichotomization of abortions.
C1 [Mourtzi, N.; Anastasiou, C. A.; Scarmeas, N.] Univ Athens, Aeginit Hosp, Neurol Clin 1, Dept Social Med Psychiat & Neurol, Vasilissis Sofias 72, Athens 11528, Greece.
   [Yannakoulia, M.; Ntanasi, E.; Anastasiou, C. A.] Harokopio Univ, Dept Nutr & Dietet, Athens, Greece.
   [Kosmidis, M. H.] Aristotle Univ Thessaloniki, Sch Psychol, Lab Cognit Neurosci, Thessaloniki, Greece.
   [Dardiotis, E.; Hadjigeorgiou, G.] Univ Thessaly, Sch Med, Larisa, Greece.
   [Megalou, M.] Biomed Diagnost Lab, Athens, Greece.
   [Ntanasi, E.; Sakka, P.] Athens Assoc Alzheimers Dis & Related Disorders, Maroussi, Greece.
   [Scarmeas, N.] Columbia Univ, Gertrude H Sergievsky Ctr, Dept Neurol, Taub Inst Res Alzheimers Dis & Aging Brain, New York, NY 10027 USA.
C3 National & Kapodistrian University of Athens; Harokopio University
   Athens; Aristotle University of Thessaloniki; University of Thessaly;
   Columbia University
RP Scarmeas, N (corresponding author), Univ Athens, Aeginit Hosp, Neurol Clin 1, Dept Social Med Psychiat & Neurol, Vasilissis Sofias 72, Athens 11528, Greece.; Scarmeas, N (corresponding author), Columbia Univ, Gertrude H Sergievsky Ctr, Dept Neurol, Taub Inst Res Alzheimers Dis & Aging Brain, New York, NY 10027 USA.
EM ns257@cumc.columbia.edu
RI Kosmidis, Mary/AAN-2104-2021; Scarmeas, Nikolaos/AAD-2512-2020
OI Dardiotis, Efthimios/0000-0003-2957-641X; Anastasiou,
   Costas/0000-0002-3536-3034; Yannakoulia, Mary/0000-0003-2171-7337;
   Kosmidis, Mary/0000-0001-8790-1220; Ntanasi, Eva/0000-0001-9311-0994
FU Alzheimer's Association [IIRG-09-133014]; ESPA-EU program Excellence
   Grant (ARISTEIA) [189 10276/8/9/2011]; Ministry for Health and Social
   Solidarity (Greece) [Delta(sic)2beta/omicroniotakappa0.51657/14.4.2009]
FX This study was supported by the Grants: IIRG-09-133014 from the
   Alzheimer's Association, 189 10276/8/9/2011 from the ESPA-EU program
   Excellence Grant (ARISTEIA) and the Delta(sic)2 beta/omicron iota kappa
   0.51657/14.4.2009 of the Ministry for Health and Social Solidarity
   (Greece).
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NR 41
TC 7
Z9 8
U1 1
U2 13
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1878-7649
EI 1878-7657
J9 EUR GERIATR MED
JI Eur. Geriatr. Med.
PD JUN
PY 2018
VL 9
IS 3
BP 301
EP 310
DI 10.1007/s41999-018-0047-1
PG 10
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA GH4ND
UT WOS:000433379500004
PM 34654241
DA 2025-06-11
ER

PT J
AU Sernyak, MJ
AF Sernyak, Michael J.
TI Implementation of monitoring and management guidelines for
   second-generation antipsychotics
SO JOURNAL OF CLINICAL PSYCHIATRY
LA English
DT Article; Proceedings Paper
CT Meeting on Strategies to Integrate Physical Health Care Into Mental
   Health
CY AUG 28, 2006
CL Philadelphia, PA
ID MEDICAL-CARE; SCHIZOPHRENIA; MORTALITY
AB It has long been known that psychiatric patients experience increased morbidity and mortality associated with a range of physical disorders. Lifestyle, inadequate health care, and a variety of other factors all contribute to the poor physical health of people with severe mental illness. Second-generation antipsychotics have gained widespread acceptance for the management of patients with schizophrenia and other forms of severe mental illness. While demonstrating several advantages over first-generation antipsychotics, second-generation antipsychotics have been found to cause or exacerbate several metabolic disorders, including diabetes, obesity, dyslipidemia, and metabolic syndrome. These disorders are closely linked and consistently associated with the development of cardiovascular disease, with varying prevalence rates depending on the second-generation antipsychotic used. As a result, several authoritative guidelines have been developed for the monitoring and management of metabolic disturbances in schizophrenia and other forms of severe mental illness. Specifically, the guidelines and recommendations generated from the Mount Sinai Conference on Medical Monitoring and the American Diabetes Association/American Psychiatric Association Consensus Development Conference on Antipsychotic Drugs and Obesity and Diabetes call for a more integrated and cooperative approach between primary care physicians and mental health care providers to improve the quality of health care for people with severe mental illness. By routinely performing physical health monitoring, referrals, and/or treatment for patients with schizophrenia and other forms of severe mental illness, mental health care providers can take a lead role in transforming the current system of fragmented mental and physical health services into a system focused on early intervention, wellness, and recovery.
C1 Yale Univ, Sch Med, Dept Psychiat, West Haven, CT 06516 USA.
   Vet Affairs Connecticut Healthcare Syst, West Haven, CT USA.
C3 Yale University; US Department of Veterans Affairs; Veterans Health
   Administration (VHA); VA Connecticut Healthcare System
RP Sernyak, MJ (corresponding author), Yale Univ, Sch Med, Dept Psychiat, 950 Campbell Ave, West Haven, CT 06516 USA.
EM michael.sernyak@yale.edu
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NR 32
TC 31
Z9 33
U1 0
U2 8
PU PHYSICIANS POSTGRADUATE PRESS
PI MEMPHIS
PA P O BOX 752870, MEMPHIS, TN 38175-2870 USA
SN 0160-6689
EI 1555-2101
J9 J CLIN PSYCHIAT
JI J. Clin. Psychiatry
PY 2007
VL 68
SU 4
BP 14
EP 18
PG 5
WC Psychology, Clinical; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI); Conference Proceedings Citation Index - Science (CPCI-S); Conference Proceedings Citation Index - Social Science &amp; Humanities (CPCI-SSH)
SC Psychology; Psychiatry
GA 167PD
UT WOS:000246462700003
PM 17539695
DA 2025-06-11
ER

PT J
AU Zha, BS
   Wan, XS
   Zhang, XX
   Zha, WB
   Zhou, J
   Wabitsch, M
   Wang, GJ
   Lyall, V
   Hylemon, PB
   Zhou, HP
AF Zha, Beth S.
   Wan, Xiaoshan
   Zhang, Xiaoxuan
   Zha, Weibin
   Zhou, Jun
   Wabitsch, Martin
   Wang, Guangji
   Lyall, Vijay
   Hylemon, Phillip B.
   Zhou, Huiping
TI HIV Protease Inhibitors Disrupt Lipid Metabolism by Activating
   Endoplasmic Reticulum Stress and Inhibiting Autophagy Activity in
   Adipocytes
SO PLOS ONE
LA English
DT Article
ID ADIPOSE-TISSUE; INFECTED PATIENTS; GENE-EXPRESSION; IN-VITRO; INSULIN
   SENSITIVITY; ANTIRETROVIRAL TREATMENT; ADIPOKINE SECRETION; CELLULAR
   MECHANISMS; HUMAN PREADIPOCYTES; P-GLYCOPROTEIN
AB Background: HIV protease inhibitors (PI) are core components of Highly Active Antiretroviral Therapy (HAART), the most effective treatment for HIV infection currently available. However, HIV PIs have now been linked to lipodystrophy and dyslipidemia, which are major risk factors for cardiovascular disease and metabolic syndrome. Our previous studies have shown that HIV PIs activate endoplasmic reticulum (ER) stress and disrupt lipid metabolism in hepatocytes and macrophages. Yet, little is known on how HIV PIs disrupt lipid metabolism in adipocytes, a major cell type involved in the pathogenesis of metabolic syndrome.
   Methodology and Principal Findings: Cultured and primary mouse adipocytes and human adipocytes were used to examine the effect of frequently used HIV PIs in the clinic, lopinavir/ritonavir, on adipocyte differentiation and further identify the underlying molecular mechanism of HIV PI-induced dysregulation of lipid metabolism in adipocytes. The results indicated that lopinavir alone or in combination with ritonavir, significantly activated the ER stress response, inhibited cell differentiation, and induced cell apoptosis in adipocytes. In addition, HIV PI-induced ER stress was closely linked to inhibition of autophagy activity. We also identified through the use of primary adipocytes of CHOP-/- mice that CHOP, the major transcriptional factor of the ER stress signaling pathway, is involved in lopinavir/ritonavir-induced inhibition of cell differentiation in adipocytes. In addition, lopinavir/ritonavir-induced ER stress appears to be associated with inhibition of autophagy activity in adipocytes.
   Conclusion and Significance: Activation of ER stress and impairment of autophagy activity are involved in HIV PI-induced dysregulation of lipid metabolism in adipocytes. The key components of ER stress and autophagy signaling pathways are potential therapeutic targets for HIV PI-induced metabolic side effects in HIV patients.
C1 [Zha, Beth S.; Zha, Weibin; Hylemon, Phillip B.; Zhou, Huiping] Virginia Commonwealth Univ, Dept Microbiol & Immunol, Sch Med, Richmond, VA 23298 USA.
   [Wan, Xiaoshan; Zhou, Jun; Zhou, Huiping] Wenzhou Med Coll, Sch Pharm, Wenzhou, Zhejiang, Peoples R China.
   [Zhang, Xiaoxuan; Zha, Weibin; Wang, Guangji] China Pharmaceut Univ, Key Lab Drug Metab & Pharmacokinet, Nanjing, Jiangsu, Peoples R China.
   [Wabitsch, Martin] Univ Ulm, Div Pediat Endocrinol & Diabet, D-89069 Ulm, Germany.
   [Lyall, Vijay] Virginia Commonwealth Univ, Dept Physiol & Biophys, Sch Med, Richmond, VA USA.
   [Hylemon, Phillip B.; Zhou, Huiping] McGuire Vet Affairs Med Ctr, Richmond, VA USA.
C3 Virginia Commonwealth University; Wenzhou Medical University; China
   Pharmaceutical University; Ulm University; Virginia Commonwealth
   University; Hunter Holmes McGuire Veterinary Affairs Medical Center
RP Zhou, HP (corresponding author), Virginia Commonwealth Univ, Dept Microbiol & Immunol, Sch Med, Richmond, VA 23298 USA.
EM hzhou@vcu.edu
RI Zha, Beth Shoshana/JXM-0505-2024; Zhou, Huiping/H-6875-2019
FU National Institutes of Health [R21 AI068432, R01 AT004148,
   1F30DK085856-02]; VA Merit Award [1I01BX001390]; VCU Presidential
   Research Incentive Program Award; School of Medicine; VCU; National
   Science Foundation of China [81070245, 81270489]; VCU Department of
   Anatomy and Neurobiology Microscopy Facility; NIH-NINDS [5P30NS047463];
   NIH [DC011569]; NIH-NINDS Center [5P30NS047463]
FX The study was supported by: National Institutes of Health grants to
   Huiping Zhou (R21 AI068432, R01 AT004148) and to Beth Zha
   (1F30DK085856-02); and VA Merit Award (1I01BX001390 to Huiping Zhou).
   This study is partially supported by the VCU Presidential Research
   Incentive Program Award (Huiping Zhou), School of Medicine, VCU Bridge
   funding (Huiping Zhou) and National Science Foundation of China (Grant
   81070245 and 81270489 to Huiping Zhou). Microscopy was performed at the
   VCU Department of Anatomy and Neurobiology Microscopy Facility,
   supported, in part, with funding from NIH-NINDS Center core grant
   (5P30NS047463). The study was also supported by NIH DC011569 to Vijay
   Lyall and NIH-NINDS Center Core grant (5P30NS047463). The funders had no
   role in study design, data collection and analysis, decision to publish,
   or preparation of the manuscript.
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NR 79
TC 62
Z9 67
U1 0
U2 29
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAR 22
PY 2013
VL 8
IS 3
AR e59514
DI 10.1371/journal.pone.0059514
PG 16
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 111VQ
UT WOS:000316549400067
PM 23533630
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Romain, AJ
   Avignon, A
   Macioce, V
   Boegner, C
   Attalin, A
   Sultan, A
AF Romain, A. J.
   Avignon, A.
   Macioce, V
   Boegner, C.
   Attalin, A.
   Sultan, A.
TI Patterns of eating behavior in people with severe obesity seeking weight
   loss treatment: An exploratory study
SO APPETITE
LA English
DT Article
DE Eating behavior; Cluster; Depression; Quality of life; Physical
   activity; Emotional eating
ID QUALITY-OF-LIFE; PHYSICAL-ACTIVITY; DEPRESSIVE SYMPTOMS; QUESTIONNAIRE;
   VALIDATION; ASSOCIATION; PHENOTYPES; ADULTS
AB Although subjects with severe obesity need specific interventions, knowledge about their eating behavior, physical and mental health profiles remains insufficient. This cross-sectional study aimed to identify profiles of individuals with severe obesity based on clinical, psychological and eating behavior characteristics. We included 126 participants (103 women; mean age: 47.2 +/- 13.9 years; mean BMI: 41.0 +/- 5.7 kg/m(2)). Cluster analyses were performed to identify profiles based on age, waist circumference, eating behavior, depressive symptoms, food-related quality of life and physical activity. Metabolic syndrome components and type 2 diabetes prevalence were compared between the clusters. Three clusters were identified. Cluster 1 labeled struggling with food (48% of the population) had high scores on both emotional eating and uncontrolled eating, low score on comfort with food and they had depressive symptoms. Cluster 2, low loss of eating control (29%), had low scores on emotional eating and uncontrolled eating, and high quality of life in the psychosocial dimension. Cluster 3, pleasure from eating (22%), had the greatest score on comfort with food, the highest physical activity level, and depressive symptoms. In cluster 2, prevalence of type 2 diabetes was higher, although not statistically significant. Otherwise, no differences were found between clusters. Conclusion: Subjects with severe obesity have different profiles, partly explained by their eating behavior, associated with clinical and behavioral patterns. Further studies should confirm this cluster structure and assess how these profiles impact the evolution of obesity and whether they can help to improve the personalization of care programs.
C1 [Romain, A. J.; Avignon, A.; Boegner, C.; Attalin, A.; Sultan, A.] Univ Montpellier, Dept Nutr & Diabet, CHU Montpellier, 371 Ave Doyen Gaston Giraud, F-34295 Montpellier, France.
   [Macioce, V] Univ Montpellier, Clin Res & Epidemiol Unit, CHU Montpellier, 39 Ave Charles Flahault, F-34295 Montpellier, France.
   [Avignon, A.; Attalin, A.] Univ Montpellier, Inst Desbrest Epidemiol & Publ Hlth, INSERM, UMR 1302, Montpellier, France.
   [Sultan, A.] INSERM, U1046, Physiol & Expt Med Heart & Muscles, F-34295 Montpellier, France.
   [Romain, A. J.] Univ Montreal, Fac Med, Sch Kinesiol & Phys Act Sci, Montreal, PQ H3T 1J4, Canada.
   [Romain, A. J.] Montreal Mental Hlth Univ Inst Res Ctr, Montreal, PQ H1N 3V2, Canada.
C3 Universite de Montpellier; CHU de Montpellier; Universite de
   Montpellier; CHU de Montpellier; Institut National de la Sante et de la
   Recherche Medicale (Inserm); Universite de Montpellier; Universite de
   Montpellier; Institut National de la Sante et de la Recherche Medicale
   (Inserm); Universite de Montreal
RP Avignon, A (corresponding author), Dept Endocrinol Diabetol Nutr, 371 Ave Doyen Gaston Giraud, F-34295 Montpellier, France.
EM a-avignon@chu-montpellier.fr
RI Romain, Ahmed/AAP-5893-2020
OI Romain, Ahmed Jerome/0000-0003-1690-1375
FU Montpellier University Hospital [AOI 9110/2013-A00272-43]
FX This study was supported by a grant from Montpellier University Hospital
   (AOI 9110/2013-A00272-43).
CR Acosta A, 2021, OBESITY, V29, P662, DOI 10.1002/oby.23120
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NR 35
TC 5
Z9 6
U1 1
U2 5
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 0195-6663
EI 1095-8304
J9 APPETITE
JI Appetite
PD FEB 1
PY 2022
VL 169
AR 105797
DI 10.1016/j.appet.2021.105797
EA JAN 2022
PG 7
WC Behavioral Sciences; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Behavioral Sciences; Nutrition & Dietetics
GA 2T5YP
UT WOS:000822550200003
PM 34752827
OA Bronze, Green Submitted
DA 2025-06-11
ER

PT J
AU Protsenko, M
   Kerkelä, M
   Miettunen, J
   Auvinen, J
   Järvelin, MR
   Jones, PB
   Gissler, M
   Veijola, J
AF Protsenko, Maria
   Kerkela, Martta
   Miettunen, Jouko
   Auvinen, Juha
   Jarvelin, Marjo-Riitta
   Jones, Peter B.
   Gissler, Mika
   Veijola, Juha
TI Cardiometabolic Disorders in the Offspring of Parents With Severe Mental
   Illness
SO PSYCHOSOMATIC MEDICINE
LA English
DT Article
DE schizophrenia; bipolar disorder; depression; metabolic syndrome;
   offspring; cohort study; CI = confidence interval; CRHC = Care Register
   for Health Care; HR = hazard ratio; NFBC1966=Northern Finland Birth
   Cohort 1966; SMI = severe mental illness
ID MAJOR DEPRESSIVE DISORDER; ALCOHOL-CONSUMPTION; INSULIN-RESISTANCE;
   DIABETES-MELLITUS; RISK; SCHIZOPHRENIA; DISEASE; OBESITY; ASSOCIATIONS;
   METAANALYSIS
AB Objective The elevated prevalence of cardiometabolic disorders is consistently reported in patients with severe mental illness (SMI). We explored the association between parental SMI and offspring cardiometabolic morbidity. Our hypothesis was that offspring of people with SMI have increased morbidity risk. Method The Northern Finland Birth Cohort 1966 is a study of offspring whose date of birth was expected in 1966. The follow-up lasted until 2015 (49 years). The final study sample included 11,175 children. We used parental SMI as the exposure in the study. The following cardiometabolic disorders were used as outcome measures: diabetes mellitus, hypertension, hyperlipidemia, coronary artery disease, obesity, and cerebrovascular disorders. Results There were 139 (14.7%; hazard ratios [HR] = 1.63; 95% confidence interval [CI] = 1.36-1.94) children of parents with SMI who developed cardiometabolic disorder during follow-up and 957 (9.4%) in the comparison cohort. Statistically significant HRs were found in males (HR = 1.95; 95% CI =1.56-2.44), but not in females (HR = 1.29; 95% CI = 0.96-1.73). Conclusions Having a cardiometabolic disorder was associated with male offspring of parents with SMI. Our findings suggest that there is an elevated risk of coronary artery disease, hyperlipidemia, obesity, and hypertension in the male offspring of parents with SMI. Our results suggest that the somatic health of offspring of parents with SMI should also be considered in addition to their mental health in clinical practice.
C1 [Protsenko, Maria; Kerkela, Martta; Veijola, Juha] Univ Oulu, Dept Psychiat, Oulu, Finland.
   [Miettunen, Jouko; Auvinen, Juha; Jarvelin, Marjo-Riitta] Univ Oulu, Res Unit Clin Neurosci, Oulu, Finland.
   [Miettunen, Jouko; Auvinen, Juha; Jarvelin, Marjo-Riitta] Univ Oulu, Ctr Life Course Hlth Res, Oulu, Finland.
   [Miettunen, Jouko; Veijola, Juha] Oulu Univ Hosp, Med Res Ctr Oulu, Oulu, Finland.
   [Gissler, Mika] Finnish Inst Hlth & Welf, Informat Serv Dept, Helsinki, Finland.
   [Gissler, Mika] Univ Turku, Res Ctr Child Psychiat, Turku, Finland.
   [Gissler, Mika] Karolinska Inst, Dept Neurobiol Care Sci & Soc, Stockholm, Sweden.
   [Veijola, Juha] Univ Hosp Oulu, Dept Psychiat, Oulu, Finland.
   [Jones, Peter B.] Univ Cambridge, Dept Psychiat, Cambridge, England.
C3 University of Oulu; University of Oulu; University of Oulu; University
   of Oulu; University of Turku; Karolinska Institutet; University of
   Cambridge
RP Protsenko, M (corresponding author), Univ Oulu, Peltolantie 17, Oulu 90014, Finland.
EM maria.protsenko@oulu.fi; martta.kerkela@oulu.fi;
   jouko.miettunen@oulu.fi; juha.auvinen@oulu.fi;
   m.jarvelin@imperial.ac.uk; pbj21@cam.ac.uk; mika.gissler@thl.fi;
   juha.veijola@oulu.fi
RI Miettunen, Jouko/AAC-4334-2019; Jones, Peter/AGE-5945-2022
OI Jones, Peter Brian/0000-0002-0387-880X; Kerkela,
   Martta/0000-0002-1181-2632; Protsenko, Maria/0000-0001-5540-9039
FU University of Oulu [24000692]; Oulu University Hospital [24301140]; ERDF
   European Regional Development Fund [539/2010 A31592]
FX The authors declare that they have no conflict of interest. The Northern
   Finland Birth Cohort 1966 received financial support from University of
   Oulu Grant No. 24000692, Oulu University Hospital Grant No. 24301140,
   and ERDF European Regional Development Fund Grant No. 539/2010 A31592.
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NR 42
TC 2
Z9 2
U1 2
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0033-3174
EI 1534-7796
J9 PSYCHOSOM MED
JI Psychosom. Med.
PD JAN
PY 2022
VL 84
IS 1
BP 2
EP 9
DI 10.1097/PSY.0000000000001022
PG 8
WC Psychiatry; Psychology; Psychology, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry; Psychology
GA XP2YK
UT WOS:000730736200006
PM 34913885
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Chiu, S
   Woodbury-Fariña, MA
   Shad, MU
   Husni, M
   Copen, J
   Bureau, Y
   Cernovsky, Z
   Hou, JJ
   Raheb, H
   Terpstra, K
   Sanchez, V
   Hategan, A
   Kaushal, M
   Campbell, R
AF Chiu, Simon
   Woodbury-Farina, Michel A.
   Shad, Mujeeb U.
   Husni, Mariwan
   Copen, John
   Bureau, Yves
   Cernovsky, Zack
   Hou, J. Jurui
   Raheb, Hana
   Terpstra, Kristen
   Sanchez, Veronica
   Hategan, Ana
   Kaushal, Mike
   Campbell, Robbie
CA St Joseph Hlth Care
TI The Role of Nutrient-Based Epigenetic Changes in Buffering Against
   Stress, Aging, and Alzheimer's Disease
SO PSYCHIATRIC CLINICS OF NORTH AMERICA
LA English
DT Article
DE Alzheimer dementia; Cognition; Stress; Epigenetics diet; Nutraceuticals
ID MILD COGNITIVE IMPAIRMENT; SUPPLEMENTATION IMPROVES MEMORY;
   RISK-FACTORS; MEDITERRANEAN DIET; DNA METHYLATION; INSULIN-RESISTANCE;
   METABOLIC SYNDROME; GLUCOCORTICOID-RECEPTOR; HISTONE ACETYLATION;
   ADENOSINE RECEPTORS
AB Converging evidence identifies stress-related disorders as putative risk factors for Alzheimer Disease (AD). This article reviews evidence on the complex interplay of stress, aging, and genes-epigenetics interactions. The recent classification of AD into preclinical, mild cognitive impairment, and AD offers a window for intervention to prevent, delay, or modify the course of AD. Evidence in support of the cognitive effects of epigenetics-based diet, and nutraceuticals is reviewed. A proactive epigenetics diet and nutraceuticals program holds promise as potential buffer against the negative impact of aging and stress responses on cognition, and can optimize vascular, metabolic, and brain health in the community.
C1 [Chiu, Simon; Campbell, Robbie] Univ Western Ontario, Schulich Sch Med & Dent, Dept Psychiat, London, ON N6G 4X8, Canada.
   [Woodbury-Farina, Michel A.] Univ Puerto Rico, Sch Med, Dept Psychiat, San Juan, PR 00918 USA.
   [Shad, Mujeeb U.] Oregon Hlth & Sci Univ, Dept Psychiat, Portland, OR 97239 USA.
   [Husni, Mariwan] Lakehead Univ, Northern Ontario Med Sch, Thunder Bay, ON P7B 5E1, Canada.
   [Husni, Mariwan] Univ London Imperial Coll Sci Technol & Med, Fac Med, London SW7 2AZ, England.
   [Copen, John] Vancouver Isl Hlth Author, Dept Psychiat, Victoria, BC, Canada.
   [Copen, John] Univ Victoria, Isl Med Program, Univ British Columbia Victoria Med Campus, Victoria, BC V8N 1M5, Canada.
   [Bureau, Yves] Univ Western Ontario, Schulich Sch Med & Dent, Dept Med Biophys, London, ON N6G 4X8, Canada.
   [Hou, J. Jurui; Raheb, Hana] St Joseph Hlth Care, Lawson Hlth Res Inst, Epigenet Res Grp, London, ON N6A 4V2, Canada.
   [Terpstra, Kristen] Univ Toronto, Fac Nursing, Lawrence S Bloomberg, Accelerated BScN Nursing Program, Toronto, ON M5T 1P8, Canada.
   [Sanchez, Veronica] McGill Univ, Meakins Christie Labs, Montreal, PQ H2X 2P2, Canada.
   [Hategan, Ana; Kaushal, Mike] McMaster Univ Hlth Sci, St Josephs Healthcare Hamilton, Geriatr Psychiat Div, Hamilton, ON L8N 3K7, Canada.
C3 Western University (University of Western Ontario); University of Puerto
   Rico; University of Puerto Rico Medical Sciences Campus; Oregon Health &
   Science University; Lakehead University; Imperial College London;
   Vancouver Island Health Authority; University of Victoria; Western
   University (University of Western Ontario); Western University
   (University of Western Ontario); University Western Ontario Hospital;
   University of Toronto; McGill University; McMaster University; McMaster
   University Hospital
RP Chiu, S (corresponding author), Reg Mental Hlth Care London, 850 Highbury Ave, London, ON N6A 4H1, Canada.
EM schiu3207@rogers.com
RI Shad, Mujeeb/GRY-0012-2022
OI Shad, Mujeeb/0000-0002-5136-9452
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NR 180
TC 19
Z9 21
U1 2
U2 39
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0193-953X
EI 1558-3147
J9 PSYCHIAT CLIN N AM
JI Psychiatr. Clin. North Amer.
PD DEC
PY 2014
VL 37
IS 4
BP 591
EP +
DI 10.1016/j.psc.2014.09.001
PG 35
WC Psychiatry
WE Social Science Citation Index (SSCI)
SC Psychiatry
GA AX0CB
UT WOS:000346620000009
PM 25455068
DA 2025-06-11
ER

PT J
AU Jurek, JM
   Xifré, B
   Rusu, EC
   Clavero-Mestres, H
   Mahmoudian, R
   Aguilar, C
   Riesco, D
   Chicote, JU
   Martinez, S
   Vives, M
   Sabench, F
   Auguet, T
AF Jurek, Joanna Michalina
   Xifre, Belen
   Rusu, Elena Cristina
   Clavero-Mestres, Helena
   Mahmoudian, Razieh
   Aguilar, Carmen
   Riesco, David
   Ugarte Chicote, Javier
   Martinez, Salome
   Vives, Marga
   Sabench, Fatima
   Auguet, Teresa
TI Differential Profiles of Gut Microbiota-Derived Metabolites of Bile
   Acids and Propionate as Potential Predictors of Depressive Disorder in
   Women with Morbid Obesity at High Risk of Metabolic
   Dysfunction-Associated Steatotic Liver Disease-A Pilot Study
SO CURRENT ISSUES IN MOLECULAR BIOLOGY
LA English
DT Article
DE depression; metabolic dysfunction-associated steatotic liver disease;
   bile acids; microbial metabolites; obesity
ID MASLD
AB Metabolic dysfunction-associated steatotic liver disease (MASLD) is a liver condition linked to cardiometabolic diseases and mental health issues, with studies highlighting disruptions in gut microbiota activity, including bile acid (BA) metabolism. Therefore, the main aim of this exploratory analysis was to assess microbiota-derived metabolites, specifically BAs and short-chain fatty acids (SCFAs), as potential biomarkers of depressive disorder (DD) in women with morbid obesity at MASLD risk. In this pilot study, 33 females with morbid obesity who were scheduled for bariatric surgery were evaluated. Medical and clinical data were collected, and microbial metabolites from pre-surgery blood samples were analyzed. Patients were stratified according to the presence of DD. Analysis with Spearman's rank test was used to assess correlations and logistic regression models were built to evaluate biomarkers as predictors of DD risk using both receiver operating characteristic (ROC) and precision-recall curves. In this cohort, 30.3% of females were reported to have DD, in addition to significantly elevated levels of certain BAs and SCFAs, including glycodeoxycholic acid (GDCA) and propionate, which were also correlated with some metabolic biomarkers. However, there were no differences in the incidence of MASLD or metabolic syndrome between patients with DD or without. In conclusion, microbiota-derived metabolites such as GDCA and propionate may influence DD risk in females with morbid obesity; however, their potential use as predictive biomarkers should be further investigated to confirm their role in psycho-metabolic conditions.
C1 [Jurek, Joanna Michalina; Rusu, Elena Cristina; Clavero-Mestres, Helena; Mahmoudian, Razieh; Aguilar, Carmen; Riesco, David; Ugarte Chicote, Javier; Martinez, Salome; Sabench, Fatima; Auguet, Teresa] Univ Rovira & Virgili URV, Inst Invest Sanitaria Pere Virgili IISPV, Dept Med & Cirurg, Grp Recerca GEMMAIR AGAUR Med Aplicada URV, Mallafre Guasch 4, Tarragona 43007, Spain.
   [Xifre, Belen] Hosp Vendrell, Serv Med Interna, Ctra Barcelona S-N, Tarragona 43700, Spain.
   [Riesco, David; Auguet, Teresa] Hosp Univ Tarragona Joan XXIII, Serv Med Interna, Mallafre Guasch, Mallafre Guasch 4, Tarragona 43007, Spain.
   [Ugarte Chicote, Javier; Martinez, Salome] Hosp Univ Tarragona Joan XXIII, Serv Anat Patol, Mallafre Guasch 4, Tarragona 43007, Spain.
   [Vives, Marga; Sabench, Fatima] Univ Rovira & Virgili URV, Inst Invest Sanitaria Pere Virgili IISPV, Hosp St Joan Reus, Dept Med & Cirurgia,Serv Cirurgia, Avinguda Doctor Josep Laporte 2, Reus 43204, Spain.
C3 Universitat Rovira i Virgili; Institut d'Investigacio Sanitaria Pere
   Virgili (IISPV); Universitat Rovira i Virgili; Hospital Universitari De
   Tarragona Joan XXIII; Universitat Rovira i Virgili; Hospital
   Universitari De Tarragona Joan XXIII; Universitat Rovira i Virgili;
   Institut d'Investigacio Sanitaria Pere Virgili (IISPV)
RP Auguet, T (corresponding author), Univ Rovira & Virgili URV, Inst Invest Sanitaria Pere Virgili IISPV, Dept Med & Cirurg, Grp Recerca GEMMAIR AGAUR Med Aplicada URV, Mallafre Guasch 4, Tarragona 43007, Spain.; Auguet, T (corresponding author), Hosp Univ Tarragona Joan XXIII, Serv Med Interna, Mallafre Guasch, Mallafre Guasch 4, Tarragona 43007, Spain.
EM joanna.michalina.jurek@gmail.com; elena.cristina.rusu@gmail.com;
   helena.clavero@urv.cat; tauguet.hj23.ics@gencat.cat
RI Auguet, Teresa/AAC-5838-2020; Sabench, Fatima/HSG-1966-2023
FU Agencia de Gestio d'Ajuts Universitaris de Recerca (AGAUR) [SGR 00030];
   URV [2021-10-837-AUGUET, 2023POST-INV-10, E-43-20232-0070021]
FX This research received external funding from Agencia de Gestio d'Ajuts
   Universitaris de Recerca (AGAUR 2021 SGR 00030 to Teresa Auguet) via
   Investigador actiu Program from the URV (2021-10-837-AUGUET to Teresa
   Auguet), via Programa INVESTIGO-URV-Codigo: 2023POST-INV-10 by Next
   Generation EU, and via Programa INVESTIGO-IISPV-Codigo:
   E-43-20232-0070021 by Next Generation EU.
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NR 56
TC 0
Z9 0
U1 0
U2 0
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
SN 1467-3037
EI 1467-3045
J9 CURR ISSUES MOL BIOL
JI Curr. Issues Mol. Biol.
PD MAY 12
PY 2025
VL 47
IS 5
AR 353
DI 10.3390/cimb47050353
PG 15
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 3AH7K
UT WOS:001495575200001
DA 2025-06-11
ER

PT J
AU Wang, Q
   Zhu, XC
   Liu, H
   Ran, MS
   Fang, DZ
AF Wang, Qian
   Zhu, Xing Chun
   Liu, Hui
   Ran, Mao Sheng
   Fang, Ding Zhi
TI A longitudinal study of the association of adiponectin gene rs1501299
   with depression in Chinese Han adolescents after Wenchuan earthquake
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Adiponectin; Genetic variation; Depression; Adolescent; Earthquake
ID CORONARY-ARTERY-DISEASE; MAJOR DEPRESSION; METABOLIC SYNDROME; SERUM
   ADIPONECTIN; PLASMA; RISK; SYMPTOMS; RESISTIN; ATHEROSCLEROSIS;
   POLYMORPHISMS
AB Background: Previous studies showed inconsistent results of the association between plasma adiponectin and depression. The aim of this study is to longitudinally investigate the association of adiponectin is 1501299 with depression in Chinese Han adolescents who experienced the 2008 Wenchuan earthquake.
   Method: Variants of adiponectin rs1501299 were identified by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis. Depressive symptoms were assessed by Beck Depression Inventory (BDI) among 746 high school students at 6, 12 and 18 months after the earthquake.
   Results: The female T allele carriers of adiponectin rs1501299 had lower prevalence of depression (p=0.008) and BDI scores (p=0.024) than the female GG homozygotes at 18 months, but not at 6 or 12 months after the earthquake, which were significantly reduced (p=0.022 for the prevalence and p < 0.001 for the scores) in the female T allele carriers at 18 months after the earthquake when compared with those at 12 months. In addition, the major predictors of depression for the GG homozygotes were gender and age at 6, 12 and 18 months after earthquake. On the other hand, the major predictor for the T allele carriers was gender at 6, 12 and 18 months after earthquake.
   Limitations: There were some limitations in the present study. First, adiponectin expressions including serum adiponectin and mRNA in adipose tissues were not measured. Second, the effect of body mass index was not evaluated.
   Conclusions: The adiponectin T allele is associated with reduced prevalence of depression and lower BDI scores of female adolescents in the later stage of rehabilitation of depression. (C) 2015 Elsevier By. All rights reserved.
C1 [Wang, Qian; Zhu, Xing Chun; Liu, Hui; Fang, Ding Zhi] Sichuan Univ, West China Sch Preclin & Forens Med, Dept Biochem & Mol Biol, Chengdu 610064, Peoples R China.
   [Ran, Mao Sheng] Univ Hong Kong, Dept Social Work & Social Adm, Hong Kong, Hong Kong, Peoples R China.
C3 Sichuan University; University of Hong Kong
RP Ran, MS (corresponding author), Univ Hong Kong, Dept Social Work & Social Adm, Hong Kong, Hong Kong, Peoples R China.
EM ranmaosh@yahoo.com; dzfang@scu.edu.cn
RI Ran, Mao-Sheng/I-7957-2013
OI Ran, Mao-Sheng/0000-0001-7343-3729
FU National Natural Science Foundation of China [81370375]
FX The study was supported by the National Natural Science Foundation of
   China (Grant no. 81370375). Dr. Ding Zhi Fang is the recipient of the
   grant.
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NR 34
TC 8
Z9 8
U1 0
U2 23
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD APR 1
PY 2015
VL 175
BP 86
EP 91
DI 10.1016/j.jad.2014.12.056
PG 6
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA CD3JL
UT WOS:000350974300009
PM 25597795
DA 2025-06-11
ER

PT J
AU Jaarsma, C
   Vink, H
   van Haare, J
   Bekkers, SCAM
   van Rooijen, BD
   Backes, WH
   Wildberger, JE
   Crijns, HJ
   van Teeffelen, J
   Schalla, S
AF Jaarsma, Caroline
   Vink, Hans
   van Haare, Judith
   Bekkers, Sebastiaan C. A. M.
   van Rooijen, Bart D.
   Backes, Walter H.
   Wildberger, Joachim E.
   Crijns, Harry J.
   van Teeffelen, Jurgen
   Schalla, Simon
TI Non-invasive assessment of microvascular dysfunction in patients with
   microvascular angina
SO INTERNATIONAL JOURNAL OF CARDIOLOGY
LA English
DT Article
DE Endothelium; Imaging; Magnetic resonance imaging; Microcirculation;
   Syndrome X
ID CARDIAC SYNDROME-X; CARDIOVASCULAR MAGNETIC-RESONANCE;
   CORONARY-ARTERY-DISEASE; TRANSMURAL MYOCARDIAL-PERFUSION; GLYCOCALYX
   BARRIER PROPERTIES; ENDOTHELIAL GLYCOCALYX; CHEST-PAIN; ISCHEMIA;
   RESERVE; FLOW
AB Background: We aimed to evaluate the microvascular function in patients with microvascular angina (MVA) by assessing 1) the endothelial glycocalyx barrier properties using sublingual microscopy, and 2) the myocardial perfusion reserve using cardiovascular magnetic resonance (CMR) imaging.
   Methods: Sublingual microscopy was performed in 13MVA patients (angina pectoris, ST-depression on treadmill testing, normal coronary angiogram) and comparedwith 2 control groups of 13 volunteers and 14 patients with known obstructive coronary artery disease (CAD). To test the glycocalyx-mediated microvascular responsiveness, the erythrocyte perfused boundary region (PBR) was assessed at baseline and after nitroglycerin challenge.
   Results: The baseline PBR of MVA patients was similar to controls with CAD (p = 0.72), and larger than in volunteers (p = 0.02). Only the volunteers demonstrated a significant increase in PBR after nitroglycerin (p = 0.03). In the 13MVA patients, adenosine stress CMR perfusion imaging was performed. Although a significant increase in myocardial perfusion was observed in both the subendocardiumand subepicardium during stress, the subendocardial perfusion reserve was significantly lower (p = 0.02). The PBR responsiveness of the sublingual microvasculature showed a strong correlation with the transmural myocardial perfusion reserve (r = 0.86, p < 0.001).
   Conclusions: Patients with MVA can be characterized by microvascular glycocalyx dysfunction using sublingual microscopy. The strong correlation between sublingual PBR responsiveness and myocardial perfusion reserve suggests that the glycocalyx may play an important role in the regulation of microvascular volume for myocardial perfusion and supports the concept of impaired glycocalyx barrier properties in MVA. (C) 2017 Elsevier B.V. All rights reserved.
C1 [Jaarsma, Caroline; Bekkers, Sebastiaan C. A. M.; Crijns, Harry J.; Schalla, Simon] Maastricht Univ, Med Ctr, Dept Cardiol, P Debyelaan 25,POB 5800, NL-6202 AZ Maastricht, Netherlands.
   [Bekkers, Sebastiaan C. A. M.; van Rooijen, Bart D.; Backes, Walter H.; Wildberger, Joachim E.; Schalla, Simon] Maastricht Univ, Med Ctr, Dept Radiol & Nucl Med, Maastricht, Netherlands.
   [Vink, Hans; van Haare, Judith; van Teeffelen, Jurgen] Maastricht Univ, Dept Physiol, Maastricht, Netherlands.
   [Vink, Hans; van Haare, Judith; Bekkers, Sebastiaan C. A. M.; Wildberger, Joachim E.; Crijns, Harry J.; van Teeffelen, Jurgen; Schalla, Simon] Maastricht Univ, Cardiovasc Res Inst Maastricht CARIM, Maastricht, Netherlands.
C3 Maastricht University; Maastricht University Medical Centre (MUMC);
   Maastricht University; Maastricht University; Maastricht University
RP Schalla, S (corresponding author), Maastricht Univ, Med Ctr, Dept Cardiol, P Debyelaan 25,POB 5800, NL-6202 AZ Maastricht, Netherlands.
EM s.schalla@mumc.nl
RI Bekkers, Sebastiaan/Y-1484-2019; Crijns, Harry/ACF-4932-2022
OI Wildberger, Joachim/0000-0002-4810-6854
FU Netherlands Heart Foundation [2009B056]
FX This study was supported by the Netherlands Heart Foundation (grant
   #2009B056).
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NR 38
TC 18
Z9 19
U1 0
U2 18
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0167-5273
EI 1874-1754
J9 INT J CARDIOL
JI Int. J. Cardiol.
PD DEC 1
PY 2017
VL 248
BP 433
EP 439
DI 10.1016/j.ijcard.2017.05.010
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA FH8JG
UT WOS:000411439900080
PM 28733074
OA hybrid
DA 2025-06-11
ER

PT J
AU Berenbaum, F
AF Berenbaum, Francis
TI Republished viewpoint: Diabetes-induced osteoarthritis: from a new
   paradigm to a new phenotype
SO POSTGRADUATE MEDICAL JOURNAL
LA English
DT Article
ID GLYCATION END-PRODUCTS; METABOLIC SYNDROME; OXIDATIVE STRESS; ARTICULAR
   CHONDROCYTES; GLUCOSE-TRANSPORT; KNEE; CARTILAGE; HYPERGLYCEMIA;
   INFLAMMATION; ACTIVATION
AB Several epidemiological and experimental data support the hypothesis that diabetes could be an independent risk factor for osteoarthritis (OA), at least in some patients, leading to the concept of a diabetes-induced OA phenotype. If confirmed, this new paradigm will have a dramatic impact on prevention of QA intiation and progression.
C1 Univ Paris 06, Hop St Antoine, APHP, Dept Rheumatol, Paris, France.
C3 Assistance Publique Hopitaux Paris (APHP); Sorbonne Universite; Hopital
   Universitaire Saint-Antoine - APHP; Universite Paris Cite; Hopital
   Universitaire Hotel-Dieu - APHP; Hopital Universitaire Ambroise-Pare -
   APHP
RP Berenbaum, F (corresponding author), Univ Paris 06, Hop St Antoine, APHP, Dept Rheumatol, Paris, France.
EM francis.berenbaum@sat.aphp.fr
RI Berenbaum, Francis/AAO-5690-2020
OI berenbaum, francis/0000-0001-8252-7815
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NR 37
TC 45
Z9 53
U1 0
U2 6
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 0032-5473
EI 1469-0756
J9 POSTGRAD MED J
JI Postgrad. Med. J.
PD APR
PY 2012
VL 88
IS 1038
BP 240
EP 242
DI 10.1136/pgmj.2010.146399rep
PG 3
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 916QS
UT WOS:000302118900010
PM 22441236
DA 2025-06-11
ER

PT J
AU Thalitaya, MD
   Udu, V
   Nicholls, M
   Clark, T
   Prasher, VP
AF Thalitaya, Madhusudan Deepak
   Udu, Victor
   Nicholls, Maggie
   Clark, Terry
   Prasher, Verinder P.
TI POMHS 9B-ANTIPSYCHOTIC PRESCRIBING IN PEOPLE WITH A LEARNING DISABILITY
SO PSYCHIATRIA DANUBINA
LA English
DT Article
DE antipsyschotic prescribing; learning diisabilty
AB Introduction: Prescribing Observatory for Mental Health (POMH-UK) runs national audit-based quality improvement programmes open to all specialist mental health services in the UK to help improve prescribing practice in discrete areas.
   Aims: The baseline sample and this re-audit represent the largest audits of antipsychotic prescribing in PWLD that have been conducted to date; and thus provide the most generalisable picture of such prescribing nationally.
   Methodology: A case note audit of use of antipsychotic medication in PWLD was conducted using standard data collection tool provided by POMH-UK. Trust wide, 7 clinical teams in Essex and Bedfordshire & Luton, participated in the re-audit. Analysis and benchmarking was conducted centrally by POMH-UK and an individualised Trust report was compiled by POMH-UK for local review and consideration.
   Standards: The indication for treatment with antipsychotic medication should be documented in the clinical records (Deb 2006). The continuing need for antipsychotic medication should be reviewed at least once a year (Deb 2006). Side effects of antipsychotic medication should be reviewed at least once a year. This review should include assessment for the presence of extrapyramidal side effects (EPS), and screening for the 4 aspects of the metabolic syndrome: obesity, hypertension, impaired glucose tolerance and dyslipidaemia (NICE schizophrenia guideline update CG82, 2009).
   Findings: Out of three standards measured, Standard One maintained 100% throughout the baseline and re-audit and Standard Two achieved over 90% throughout baseline and re-audit. Standard 3 has improved from baseline to re-audit. Overall, there has been clear improvement in all 3 standards from baseline audit.
C1 [Thalitaya, Madhusudan Deepak; Udu, Victor; Nicholls, Maggie; Clark, Terry; Prasher, Verinder P.] S Essex Partnership Univ NHS Fdn Trust, Twinwoods Med Ctr, Clapham MK41 6AT, Beds, England.
RP Thalitaya, MD (corresponding author), S Essex Partnership Univ NHS Fdn Trust, Twinwoods Med Ctr, Milton Rd, Clapham MK41 6AT, Beds, England.
EM Deepak.thalitaya@sept.nhs.uk
CR Deb S., 2006, Using medication to manage behaviour problems among adults with a learning disability: quick reference guide
   *NICE, 2009, NICE CLIN GUID MAN S
NR 2
TC 2
Z9 2
U1 0
U2 3
PU MEDICINSKA NAKLADA
PI ZAGREB
PA VLASKA 69, HR-10000 ZAGREB, CROATIA
SN 0353-5053
J9 PSYCHIAT DANUB
JI Psychiatr. Danub.
PD SEP
PY 2011
VL 23
SU 1
BP S50
EP S56
PG 7
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 822DG
UT WOS:000295023500013
PM 21894103
DA 2025-06-11
ER

PT J
AU Bahijri, S
   Borai, A
   Ajabnoor, G
   Khaliq, AA
   AlQassas, I
   Al-Shehri, D
   Chrousos, G
AF Bahijri, Suhad
   Borai, Anwar
   Ajabnoor, Ghada
   Khaliq, Altaf Abdul
   AlQassas, Ibrahim
   Al-Shehri, Dhafer
   Chrousos, George
TI Relative Metabolic Stability, but Disrupted Circadian Cortisol Secretion
   during the Fasting Month of Ramadan
SO PLOS ONE
LA English
DT Article
ID SLEEP-DEPRIVATION; GENE-EXPRESSION; CONSEQUENCES; STRESS; PLASMA;
   DEPRESSION; RHYTHM; MODEL; ACTH
AB Background: Chronic feeding and sleep schedule disturbances are stressors that exert damaging effects on the organism. Practicing Muslims in Saudi Arabia go through strict Ramadan fasting from dawn till sunset for one month yearly. Modern era Ramadan practices in Saudi Arabia are associated with disturbed feeding and sleep patterns, namely abstaining from food and water and increasing daytime sleep, and staying awake and receiving food and water till dawn.
   Hypothesis: Strict Ramadan practices in Saudi Arabia may influence metabolism, sleep and circadian cortisol secretion.
   Protocol: Young, male Ramadan practitioners were evaluated before and two weeks into the Ramadan. Blood samples were collected at 9.00 am and 9.00 pm for measurements of metabolic parameters and cortisol. Saliva was collected serially during the day for cortisol determinations.
   Results: Ramadan practitioners had relative metabolic stability or changes expected by the pattern of feeding. However, the cortisol circadian rhythm was abolished and circulating insulin levels and HOMA index were increased during this period.
   Discussion: The flattening of the cortisol rhythm is typical of conditions associated with chronic stress or endogenous hypercortisolism and associated with insulin resistance.
   Conclusions: Modern Ramadan practices in Saudi Arabia are associated with evening hypercortisolism and increased insulin resistance. These changes might contribute to the high prevalence of chronic stress-related conditions, such as central obesity, hypertension, metabolic syndrome and diabetes mellitus type 2, and their cardiovascular sequelae observed in the Kingdom.
C1 [Bahijri, Suhad; Ajabnoor, Ghada] King Abdulaziz Univ, Fac Med, Dept Clin Biochem, Jeddah 21413, Saudi Arabia.
   [Bahijri, Suhad; Borai, Anwar; Ajabnoor, Ghada; Khaliq, Altaf Abdul; AlQassas, Ibrahim; Al-Shehri, Dhafer; Chrousos, George] King Abdulaziz Univ, King Fahd Med Res Ctr, Saudi Diabet Study Res Grp, Jeddah 21413, Saudi Arabia.
   [Borai, Anwar] King Abdul Aziz Med City, King Abdullah Int Med Res Ctr, Jeddah, Saudi Arabia.
   [Khaliq, Altaf Abdul] Um Alqura Univ, Fac Allied Med Sci, Dept Clin Biochem, Mecca, Saudi Arabia.
   [Chrousos, George] Univ Athens, Sch Med, Aghia Sophia Childrens Hosp, Dept Pediat, GR-11527 Athens, Greece.
C3 King Abdulaziz University; King Abdulaziz University; King Saud Bin
   Abdulaziz University for Health Sciences; King Abdulaziz Medical City -
   Jeddah; Umm Al-Qura University; Athens Medical School; National &
   Kapodistrian University of Athens; The Aghia Sophia Children's Hospital
RP Borai, A (corresponding author), King Abdulaziz Univ, King Fahd Med Res Ctr, Saudi Diabet Study Res Grp, Jeddah 21413, Saudi Arabia.
EM boraiaa@ngha.med.sa
RI ABDULKHALIQ, ALTAF/JNE-7040-2023; AlShehri, Dhafer/B-5950-2015; Bahijri,
   Suhad/AAF-4141-2020; ajabnoor, ghada/H-5128-2012; Chrousos,
   George/G-8702-2011
OI ABDULKHALIQ, ALTAF AHMED/0000-0002-8148-1103; Bahijri,
   Suhad/0000-0001-6674-5409
FU deanship of research at King Abdulaziz University - Jeddah-Kingdom of
   Saudi Arabia [HiCi/1432-6-2]
FX This study was supported by the deanship of research at King Abdulaziz
   University - Jeddah-Kingdom of Saudi Arabia under grant number
   (HiCi/1432-6-2) as part of a main research project conducted by "Saudi
   Diabetes Study Research Group''. The funders had no role in study
   design, data collection and analysis, decision to publish, or
   preparation of the manuscript.
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NR 31
TC 71
Z9 74
U1 2
U2 16
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD APR 18
PY 2013
VL 8
IS 4
AR e60917
DI 10.1371/journal.pone.0060917
PG 6
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 130IU
UT WOS:000317908700010
PM 23637777
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Miles, LW
   Williams, N
   Luthy, KE
   Eden, L
AF Miles, Leslie W.
   Williams, Nathalia
   Luthy, Karlen E.
   Eden, Lacey
TI Adult Vaccination Rates in the Mentally Ill Population: An Outpatient
   Improvement Project
SO JOURNAL OF THE AMERICAN PSYCHIATRIC NURSES ASSOCIATION
LA English
DT Article
DE health services; patient satisfaction; quantitative research; serious
   mental illness
ID METABOLIC SYNDROME; IMMUNIZATION; ILLNESS; HEALTH; CARE; PEOPLE;
   SCHIZOPHRENIA; OLDER; NEED
AB Background: Adults who suffer with severe and persistent mental illness (SPMI) rarely access medical care to receive preventive vaccines. Aims: To increase the rate of vaccines among the SPMI population in an outpatient community mental health center (CMHC). Methods: A review of the literature identified a gap between the general population and SPMI clients in receiving preventive vaccinations. An initial mixed-method convenience survey of SPMI clients (n = 392) provided information on current vaccination status, demographics, beliefs, and interest in receiving vaccines. A vaccination program was developed to address identified barriers and increase vaccination rates. Postintervention data were collected through a mixed-method convenience survey of SPMI clients (n = 60) who participated in immunizations clinics to evaluate client satisfaction. A partnership between the health department and CMHC was developed to deliver vaccines in a nontraditional site. Vaccines administered included annual influenza; hepatitis A; hepatitis B; herpes zoster; measles, mumps, and rubella; pneumococcal; and tetanus, diphtheria, and pertussis (Tdap). Results: More than 1,000 vaccines were administered in the first 8 months, with a significant increase in vaccination rates over baseline for individual vaccines ranging from 18.75% to 83%. Postintervention survey results found a 95% satisfaction rate. Conclusions: Implementation of a vaccination program in a nontraditional site that facilitates access for SPMI clients can promote an overwhelming increase in the vaccination rates for this underserved population. Results suggest that the integration of mental health and CMHC services can have a profound positive effect on SPMI population health.
C1 [Miles, Leslie W.; Williams, Nathalia; Luthy, Karlen E.; Eden, Lacey] Brigham Young Univ, 500 KMBL, Provo, UT 84602 USA.
C3 Brigham Young University
RP Miles, LW (corresponding author), Brigham Young Univ, 500 KMBL, Provo, UT 84602 USA.
EM leslie-miles@byu.edu
OI Miles, Leslie/0000-0002-1964-8929
CR Alpert PT, 2015, HOME HLTH CARE MAN P, V27, P41, DOI 10.1177/1084822314537071
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   Centers for Disease Control and Prevention, 2016, GUID PUBL IMM MAN
   Centers for Disease Control and Prevention, 2012, ADV COMM IMM PRACT M
   Centers for Disease Control and Prevention, 2008, VACC COV US AD NAT I
   Centers for Medicare and Medicaid Services, 2018, IMM
   Clubhouse International, 2016, WHAT WE DO
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NR 41
TC 56
Z9 57
U1 0
U2 5
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1078-3903
EI 1532-5725
J9 J AM PSYCHIAT NURSES
JI J. Am. Psych. Nurses Assoc.
PD MAR
PY 2020
VL 26
IS 2
BP 172
EP 180
DI 10.1177/1078390319831763
PG 9
WC Nursing; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Psychiatry
GA LA3KY
UT WOS:000523850500006
PM 30866701
DA 2025-06-11
ER

PT J
AU Varga, B
   Kassai, F
   Szabó, G
   Kovács, P
   Fischer, J
   Gyertyán, I
AF Varga, Balazs
   Kassai, Ferenc
   Szabo, Gyorgy
   Kovacs, Peter
   Fischer, Janos
   Gyertyan, Istvan
TI Pharmacological comparison of traditional and non-traditional
   cannabinoid receptor 1 blockers in rodent models in vivo
SO PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
LA English
DT Article
DE Cannabinoid; Antagonist; Pharmacological; Comparison; Obesity; Anxiety
ID CB1 RECEPTOR; FOOD-INTAKE; ULTRASONIC VOCALIZATION; ANTAGONIST
   RIMONABANT; EMOTIONAL REACTIVITY; SELECTIVE ANTAGONIST;
   METABOLIC-DISORDERS; LEPTIN RESISTANCE; INVERSE AGONISM; ANXIETY-LIKE
AB Cannabinoid receptor 1 (CB1R) antagonists have been proven to be effective anti-obesity drugs; however, psychiatric side effects have halted their pharmaceutical development worldwide. Despite the emergence of next generation CB1R blockers, a preclinical head to head comparison of the anti-obesity and psychiatric side effect profiles of the key compounds has not been performed. Here, we compared classical CB1R antagonists (rimonabant, taranabant, otenabant, ibipinabant, and surinabant) and non-traditional CB1R blockers (the partial agonist 0-1269, the neutral antagonists VCHSR and LH-21 and the peripherally acting inverse agonist JD-5037) using an in vivo screening cascade. First, the potencies of these compounds to reduce CB1R agonist-induced hypothermia and decrease fasting-induced food intake were determined. Then, equipotent doses of the non-toxic compounds were compared in a diet-induced obesity (DIO) test, which includes measurements of metabolic syndrome markers. Psychiatric side effects were assessed by measuring anxiogenicity in an ultrasonic vocalization test. All classical CB1R blockers were centrally acting appetite suppressants and decreased body weight and food intake in an obesity-dependent manner, with only slight effects on metabolic syndrome markers. In addition, all classical CB1R blockers increased ultrasonic vocalization. Surprisingly, none of the non-classical CB1R blockers was eligible for the DIO comparison and side effect profiling. 0-1269 and LH-21 induced convulsive behavior, whereas VCHSR and JD-5037 were devoid of any in vivo activity. The classical CB1R blockers displayed similar therapeutic and side effect profiles in vivo, whereas the available non-traditional CB1R blockers were not appropriate tools for testing the therapeutic potential of alternative CB1R inhibitors.
C1 [Varga, Balazs; Kassai, Ferenc; Szabo, Gyorgy; Kovacs, Peter; Fischer, Janos; Gyertyan, Istvan] Gedeon Richter Plc, 10,POB 27, H-1475 Budapest, Hungary.
   [Kassai, Ferenc; Gyertyan, Istvan] Semmelweis Univ, Dept Pharmacol & Pharmacotherapy, MTA SE NAP Cognit Translat Behav Pharmacol Grp B, Nagyvarad Ter 4, H-1089 Budapest, Hungary.
   [Kassai, Ferenc; Gyertyan, Istvan] Hungarian Acad Sci, Res Ctr Nat Sci, Inst Cognit Neurosci & Psychol, Magyar Tudosok Korutja 2, H-1117 Budapest, Hungary.
   [Kovacs, Peter] Berlin Chem A Menarini Magyarorszag Kft, Neumann Janos U 1, H-2040 Budaors, Hungary.
C3 Gedeon Richter Chemistry Works; Semmelweis University; Hungarian Academy
   of Sciences; HUN-REN; HUN-REN Research Centre for Natural Sciences;
   Institute of Cognitive Neuroscience & Psychology - HAS
RP Varga, B (corresponding author), Gedeon Richter Plc, Gyomroi Ut 19-21, H-1103 Budapest, Hungary.
EM b.varga@richter.hu
RI Varga, Balázs/K-5637-2019; Gyertyan, Istvan/K-2174-2017
OI Kovacs, Peter/0000-0001-5732-7432; Gyertyan, Istvan/0000-0002-5727-1974;
   Varga, Balazs/0000-0002-2925-7868
FU Gedeon Richter Plc
FX The study was funded by Gedeon Richter Plc.
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NR 60
TC 5
Z9 5
U1 1
U2 8
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0091-3057
J9 PHARMACOL BIOCHEM BE
JI Pharmacol. Biochem. Behav.
PD AUG
PY 2017
VL 159
BP 24
EP 35
DI 10.1016/j.pbb.2017.06.012
PG 12
WC Behavioral Sciences; Neurosciences; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Behavioral Sciences; Neurosciences & Neurology; Pharmacology & Pharmacy
GA FE4IS
UT WOS:000408178200005
PM 28666894
DA 2025-06-11
ER

PT S
AU Woodward, A
   Klonizakis, M
   Broom, D
AF Woodward, Amie
   Klonizakis, Markos
   Broom, David
BE Xiao, J
TI Exercise and Polycystic Ovary Syndrome
SO PHYSICAL EXERCISE FOR HUMAN HEALTH
SE Advances in Experimental Medicine and Biology
LA English
DT Article; Book Chapter
DE Polycystic ovary syndrome; Exercise; Physical activity; Reproductive
   health; Cardiovascular disease
ID CARDIOVASCULAR-DISEASE RISK; OBSTRUCTIVE SLEEP-APNEA;
   INSULIN-RESISTANCE; OBESE WOMEN; MENTAL-HEALTH; METABOLIC SYNDROME;
   PHYSICAL-ACTIVITY; AEROBIC EXERCISE; TRAINING-PROGRAM; ANDROGEN EXCESS
AB Polycystic ovary syndrome (PCOS) is a complex endocrinopathy affecting both the metabolism and reproductive system of women of reproductive age. Prevalence ranges from 6.1-19.9% depending on the criteria used to give a diagnosis. PCOS accounts for approximately 80% of women with anovulatory infertility, and causes disruption at various stages of the reproductive axis. Evidence suggests lifestyle modification should be the first line of therapy for women with PCOS. Several studies have examined the impact of exercise interventions on reproductive function, with results indicating improvements in menstrual and/or ovulation frequency following exercise. Enhanced insulin sensitivity underpins the mechanisms of how exercise restores reproductive function. Women with PCOS typically have a cluster of metabolic abnormalities that are risk factors for CVD. There is irrefutable evidence that exercise mitigates CVD risk factors in women with PCOS. The mechanism by which exercise improves many CVD risk factors is again associated with improved insulin sensitivity and decreased hyperinsulinemia. In addition to cardiometabolic and reproductive complications, PCOS has been associated with an increased prevalence of mental health disorders. Exercise improves psychological well-being in women with PCOS, dependent on certain physiological factors. An optimal dose-response relationship to exercise in PCOS may not be feasible because of the highly individualised characteristics of the disorder. Guidelines for PCOS suggest at least 150 min of physical activity per week. Evidence confirms that this should form the basis of any clinician or healthcare professional prescription.
C1 [Woodward, Amie; Klonizakis, Markos; Broom, David] Sheffield Hallam Univ, Ctr Sport & Exercise Sci, Fac Hlth & Wellbeing, Sheffield, S Yorkshire, England.
C3 Sheffield Hallam University
RP Broom, D (corresponding author), Sheffield Hallam Univ, Ctr Sport & Exercise Sci, Fac Hlth & Wellbeing, Sheffield, S Yorkshire, England.
EM d.r.broom@shu.ac.uk
RI Woodward, Amie/LUZ-5979-2024; Klonizakis, Markos/A-3680-2009
OI Klonizakis, Markos/0000-0002-8864-4403; Woodward,
   Amie/0000-0002-9579-4012; Broom, David/0000-0002-0305-937X
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NR 108
TC 32
Z9 33
U1 5
U2 42
PU SPRINGER-VERLAG SINGAPORE PTE LTD
PI SINGAPORE
PA 152 BEACH ROAD, #21-01/04 GATEWAY EAST, SINGAPORE, 189721, SINGAPORE
SN 0065-2598
EI 2214-8019
BN 978-981-15-1792-1; 978-981-15-1791-4
J9 ADV EXP MED BIOL
JI Adv.Exp.Med.Biol.
PY 2020
VL 1228
BP 123
EP 136
DI 10.1007/978-981-15-1792-1_8
D2 10.1007/978-981-15-1792-1
PG 14
WC Medicine, Research & Experimental; Physiology; Sport Sciences
WE Book Citation Index – Science (BKCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Physiology; Sport Sciences
GA BQ5AS
UT WOS:000596720900008
PM 32342454
DA 2025-06-11
ER

PT J
AU Yaribeygi, H
   Farrokhi, FR
   Butler, AE
   Sahebkar, A
AF Yaribeygi, Habib
   Farrokhi, Farin Rashid
   Butler, Alexandra E.
   Sahebkar, Amirhossein
TI Insulin resistance: Review of the underlying molecular mechanisms
SO JOURNAL OF CELLULAR PHYSIOLOGY
LA English
DT Review
DE diabetes mellitus; GLUT-4; insulin receptor substrate; insulin
   resistance; insulin sensitivity; insulin signaling; oxidative stress;
   TNF-alpha
ID ENDOPLASMIC-RETICULUM STRESS; OXIDATIVE STRESS; DIABETES-MELLITUS;
   ADIPOSE-TISSUE; MICE LACKING; TNF-ALPHA; ER-STRESS; METABOLIC
   CONSEQUENCES; TARGETED DISRUPTION; RECEPTOR ANTIBODIES
AB Most human cells utilize glucose as the primary substrate, cellular uptake requiring insulin. Insulin signaling is therefore critical for these tissues. However, decrease in insulin sensitivity due to the disruption of various molecular pathways causes insulin resistance (IR). IR underpins many metabolic disorders such as type 2 diabetes and metabolic syndrome, impairments in insulin signaling disrupting entry of glucose into the adipocytes, and skeletal muscle cells. Although the exact underlying cause of IR has not been fully elucidated, a number of major mechanisms, including oxidative stress, inflammation, insulin receptor mutations, endoplasmic reticulum stress, and mitochondrial dysfunction have been suggested. In this review, we consider the role these cellular mechanisms play in the development of IR.
C1 [Yaribeygi, Habib; Farrokhi, Farin Rashid] Shahid Beheshti Univ Med Sci, Chron Kidney Dis Res Ctr, Tehran, Iran.
   [Butler, Alexandra E.] Qatar Biomed Res Inst, Diabetes Res Ctr, Doha, Qatar.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Neurogen Inflammat Res Ctr, Mashhad, Iran.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Biotechnol Res Ctr, Mashhad, Iran.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Sch Pharm, Mashhad, Iran.
C3 Shahid Beheshti University Medical Sciences; Qatar Foundation (QF);
   Hamad Bin Khalifa University-Qatar; Qatar Biomedical Research Institute
   (QBRI); Mashhad University of Medical Sciences; Mashhad University of
   Medical Sciences; Mashhad University of Medical Sciences
RP Yaribeygi, H (corresponding author), Shahid Beheshti Univ Med Sci, Chron Kidney Dis Res Ctr, Tehran, Iran.; Sahebkar, A (corresponding author), Mashhad Univ Med Sci, Biotechnol Res Ctr, Mashhad 9177948564, Iran.
EM habib.yari@yahoo.com; sahebkara@mums.ac.ir
RI farokhi, farin/G-6473-2017; Sahebkar, Amirhossein/B-5124-2018;
   Yaribeygi, Habib/R-8998-2019
OI Yaribeygi, Habib/0000-0002-1706-6212; Butler,
   Alexandra/0000-0002-5762-3917
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NR 103
TC 594
Z9 651
U1 29
U2 535
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0021-9541
EI 1097-4652
J9 J CELL PHYSIOL
JI J. Cell. Physiol.
PD JUN
PY 2019
VL 234
IS 6
BP 8152
EP 8161
DI 10.1002/jcp.27603
PG 10
WC Cell Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Physiology
GA HM2QU
UT WOS:000459314500044
PM 30317615
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Sloan, RP
   Shapiro, PA
   McKinley, PS
   Bartels, M
   Shimbo, D
   Lauriola, V
   Karmally, W
   Pavlicova, M
   Choi, CJ
   Choo, TH
   Scodes, JM
   Flood, P
   Tracey, KJ
AF Sloan, Richard P.
   Shapiro, Peter A.
   McKinley, Paula S.
   Bartels, Matthew
   Shimbo, Daichi
   Lauriola, Vincenzo
   Karmally, Wahida
   Pavlicova, Martina
   Choi, C. Jean
   Choo, Tse-Hwei
   Scodes, Jennifer M.
   Flood, Pamela
   Tracey, Kevin J.
TI Aerobic Exercise Training and Inducible Inflammation: Results of a
   Randomized Controlled Trial in Healthy, Young Adults
SO JOURNAL OF THE AMERICAN HEART ASSOCIATION
LA English
DT Article
DE clinical trial; exercise training; inflammation
ID C-REACTIVE PROTEIN; BLOOD MONONUCLEAR-CELLS; PHYSICAL-ACTIVITY;
   WEIGHT-LOSS; GLUCOCORTICOID-RECEPTOR; DEPRESSIVE SYMPTOMS; OXIDATIVE
   STRESS; PSYCHOLOGICAL STRESS; METABOLIC SYNDROME; RISK-FACTORS
AB Background-Consensus panels regularly recommend aerobic exercise for its health-promoting properties, due in part to presumed anti-inflammatory effects, but many studies show no such effect, possibly related to study differences in participants, interventions, inflammatory markers, and statistical approaches. This variability makes an unequivocal determination of the anti-inflammatory effects of aerobic training elusive.
   Methods and Results-We conducted a randomized controlled trial of 12 weeks of aerobic exercise training or a wait list control condition followed by 4 weeks of sedentary deconditioning on lipopolysaccharide (0, 0.1, and 1.0 ng/mL)-inducible tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6), and on toll-like receptor 4 in 119 healthy, sedentary young adults. Aerobic capacity by cardiopulmonary exercise testing was measured at study entry (T1) and after training (T2) and deconditioning (T3). Despite a 15% increase in maximal oxygen consumption, there were no changes in inflammatory markers. Additional analyses revealed a differential longitudinal aerobic exercise training effect by lipopolysaccharide level in inducible TNF-alpha (P=0.08) and IL-6 (P=0.011), showing T1 to T2 increases rather than decreases in inducible (lipopolysaccharide 0.1, 1.0 versus 0.0 ng/mL) TNF-alpha (51% increase, P=0.041) and IL-6 (42% increase, P=0.11), and significant T2 to T3 decreases in inducible TNF-alpha (54% decrease, P=0.007) and IL-6 (55% decrease, P<0.001). There were no significant changes in either group at the 0.0 ng/mL lipopolysaccharide level for TNF-alpha or IL-6.
   Conclusions-The failure to support the primary hypotheses and the unexpected post hoc findings of an exercise-training-induced proinflammatory response raise questions about whether and under what conditions exercise training has anti-inflammatory effects.
C1 [Sloan, Richard P.; McKinley, Paula S.; Lauriola, Vincenzo] Columbia Univ, Div Behav Med, Dept Psychiat, Mailman Sch Publ Hlth,Med Ctr, New York, NY USA.
   [Shapiro, Peter A.] Columbia Univ, Div Consultat Liaison Psychiat, Dept Psychiat, Mailman Sch Publ Hlth,Med Ctr, New York, NY USA.
   [Bartels, Matthew] Columbia Univ, Dept Rehabil Med, Mailman Sch Publ Hlth, Med Ctr, New York, NY USA.
   [Shimbo, Daichi] Columbia Univ, Dept Med, Mailman Sch Publ Hlth, Med Ctr, New York, NY USA.
   [Flood, Pamela] Columbia Univ, Dept Anesthesiol, Mailman Sch Publ Hlth, Med Ctr, New York, NY USA.
   [Pavlicova, Martina] Columbia Univ, Dept Biostat, Mailman Sch Publ Hlth, Med Ctr, New York, NY USA.
   [Karmally, Wahida] Columbia Univ, Irving Inst Clin & Translat Res, Med Ctr, New York, NY USA.
   [Sloan, Richard P.; Choi, C. Jean; Choo, Tse-Hwei; Scodes, Jennifer M.] New York State Psychiat Inst & Hosp, New York, NY 10032 USA.
   [Tracey, Kevin J.] Northwell Hlth, Feinstein Inst Med Res, Manhassett, NY USA.
   [McKinley, Paula S.] Montefiore Med Ctr, Div Gen Internal Med, Dept Med, 111 E 210th St, Bronx, NY 10467 USA.
   [Bartels, Matthew] Montefiore Med Ctr, Dept Rehabil Med, 111 E 210th St, Bronx, NY 10467 USA.
   [Flood, Pamela] Anesthesia Dept, Stanford, CA USA.
C3 Columbia University; Columbia University; Columbia University; Columbia
   University; Columbia University; Columbia University; Columbia
   University; New York State Psychiatry Institute; Northwell Health;
   Montefiore Medical Center; Albert Einstein College of Medicine;
   Montefiore Medical Center; Albert Einstein College of Medicine
RP Sloan, RP (corresponding author), Columbia Univ, Div Behav Med, Dept Psychiat, Med Ctr, 622 West 168th St, New York, NY 10032 USA.
EM rps7@columbia.edu
RI Pavlicova, Martina/ITU-3238-2023; Lauriola, Vincenzo/MCY-6392-2025;
   Flood, Pamela/C-2371-2019; McKinley, Paula/B-8666-2012
OI Flood, Pamela/0000-0001-7023-3924; Lauriola,
   Vincenzo/0000-0002-1761-7686; Tracey, Kevin J/0000-0003-1884-6314
FU National Heart, Lung, and Blood Institute (Sloan) [R01 HL094423]; NIH
   Center for Advancing Translational Sciences [UL1 TR001873]; Nathaniel
   Wharton Fund
FX This study was supported by Grant R01 HL094423 from the National Heart,
   Lung, and Blood Institute (Sloan), Grant UL1 TR001873 from the NIH
   Center for Advancing Translational Sciences, and the Nathaniel Wharton
   Fund.
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NR 75
TC 22
Z9 23
U1 2
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2047-9980
J9 J AM HEART ASSOC
JI J. Am. Heart Assoc.
PD SEP 4
PY 2018
VL 7
IS 17
AR e010201
DI 10.1161/JAHA.118.010201
PG 20
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Cardiovascular System & Cardiology
GA HD8KL
UT WOS:000452804600026
PM 30371169
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Joseph, G
   Soler, A
   Hutcheson, R
   Hunter, I
   Bradford, C
   Hutcheson, B
   Gotlinger, KH
   Jiang, HL
   Falck, JR
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AF Joseph, Gregory
   Soler, Amanda
   Hutcheson, Rebecca
   Hunter, Ian
   Bradford, Chastity
   Hutcheson, Brenda
   Gotlinger, Katherine H.
   Jiang, Houli
   Falck, John R.
   Proctor, Spencer
   Schwartzman, Michal Laniado
   Rocic, Petra
TI Elevated 20-HETE impairs coronary collateral growth in metabolic
   syndrome via endothelial dysfunction
SO AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
LA English
DT Article
DE 20-HETE; miR-145; arteriogenesis; endothelial dysfunction; neutrophils
ID 20-HYDROXYEICOSATETRAENOIC ACID SYNTHESIS; ANGIOTENSIN-II; INFLAMMATORY
   CYTOKINES; RECEPTOR BLOCKADE; HUMAN NEUTROPHILS; ARACHIDONIC-ACID;
   OXIDATIVE STRESS; KAPPA-B; HYPERTENSION; ACTIVATION
AB Coronary collateral growth (CCG) is impaired in metabolic syndrome (MetS). microRNA-145 (miR-145-Adv) delivery to our rat model of MetS (JCR) completely restored and neutrophil depletion significantly improved CCG. We determined whether low endogenous levels of miR-145 in MetS allowed for elevated production of 20-hydroxyeicosatetraenoic acid (20-HETE), which, in turn, resulted in excessive neutrophil accumulation and endothelial dysfunction leading to impaired CCG. Rats underwent 0-9 days of repetitive ischemia (RI). RI-induced cardiac CYP4F (neutrophil-specific 20-HETE synthase) expression and 20-HETE levels were increased (4-fold) in JCR vs. normal rats. miR-145-Adv and 20-HETE antagonists abolished and neutrophil depletion (blocking antibodies) reduced (similar to 60%) RI-induced increases in CYP4F expression and 20-HETE production in JCR rats. Impaired CCG in JCR rats (collateral-dependent blood flow using microspheres) was completely restored by 20-HETE antagonists [collateral-dependent zone (CZ)/normal zone (NZ) flow ratio was 0.76 +/- 0.07 in JCR +/- 20-SOLA, 0.84 +/- 0.05 in JCR + 20-HEDGE vs. 0.11 +/- 0.02 in JCR vs. 0.84 +/- 0.03 in normal rats]. In JCR rats, elevated 20-HETE was associated with excessive expression of endothelial adhesion molecules and neutrophil infiltration, which were reversed by miR-145-Adv. Endothelium-dependent vasodilation of coronary arteries, endothelial nitric oxide synthase (eNOS) Ser1179 phosphorylation, eNOS-dependent NO center dot- production and endothelial cell survival were compromised in JCR rats. These parameters of endothelial dysfunction were completely reversed by 20-HETE antagonism or miR-145-Adv delivery, whereas neutrophil depletion resulted in partial reversal similar to 70%). We conclude that low miR-145 in MetS allows for increased 20-HETE, mainly from neutrophils, which compromises endothelial cell survival and function leading to impaired CCG. 20-HETE antagonists could provide viable therapy for restoration of CCG in MetS.
   NEW & NOTEWORTHY Elevated 20-hydroxyeicosatetraenoic acid (20-HETE) impairs coronary collateral growth (CCG) in metabolic syndrome by eliciting endothelial dysfunction and apoptosis via excessive neutrophil infiltration. 20-HETE antagonists completely restore coronary collateral growth in metabolic syndrome. mi-croRNA-145 (miR-145) is an upstream regulator of 20-HETE production in metabolic syndrome; low expression of miR-145 in metabolic syndrome promotes elevated production of 20-HETE.
C1 [Joseph, Gregory; Soler, Amanda; Hutcheson, Rebecca; Hunter, Ian; Hutcheson, Brenda; Gotlinger, Katherine H.; Jiang, Houli; Schwartzman, Michal Laniado; Rocic, Petra] New York Med Coll, Dept Pharmacol, BSB 502 Dana Rd, Valhalla, NY 10595 USA.
   [Bradford, Chastity] Tuskegee Univ, Dept Biol, Tuskegee, AL USA.
   [Falck, John R.] Univ Texas Southwestern Med Ctr, Dept Pharmacol, Dallas, TX USA.
   [Proctor, Spencer] Univ Alberta, Alberta Inst Human Nutr, Metabol & Cardiovasc Dis Lab, Edmonton, AB, Canada.
C3 New York Medical College; Tuskegee University; University of Texas
   System; University of Texas Southwestern Medical Center Dallas;
   University of Alberta
RP Rocic, P (corresponding author), New York Med Coll, Dept Pharmacol, BSB 502 Dana Rd, Valhalla, NY 10595 USA.
EM petra_rocic@nymc.edu
RI Proctor, Spencer/F-2774-2012; Falck, John/B-3030-2011
OI Bradford, Chastity/0000-0001-7460-6134; Proctor,
   Spencer/0000-0002-7597-5262; Rocic, Petra/0000-0002-5781-3075
FU National Heart, Lung, and Blood Institute [R01-HL-093052, P01-HL-034300]
FX This work was supported by National Heart, Lung, and Blood Institute
   Grants R01-HL-093052 (to P. Rocic) and P01-HL-034300 (to M. L.
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NR 87
TC 32
Z9 39
U1 2
U2 10
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0363-6135
EI 1522-1539
J9 AM J PHYSIOL-HEART C
JI Am. J. Physiol.-Heart Circul. Physiol.
PD MAR
PY 2017
VL 312
IS 3
BP H528
EP H540
DI 10.1152/ajpheart.00561.2016
PG 13
WC Cardiac & Cardiovascular Systems; Physiology; Peripheral Vascular
   Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Physiology
GA EQ1DC
UT WOS:000397808500018
PM 28011587
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Williams, G
AF Williams, Graeme
TI Aromatase up-regulation, insulin and raised intracellular oestrogens in
   men, induce adiposity, metabolic syndrome and prostate disease, via
   aberrant ER-α and GPER signalling
SO MOLECULAR AND CELLULAR ENDOCRINOLOGY
LA English
DT Article
DE Aromatase; ER-alpha; GPER; Obesity; Metabolic syndrome; Prostate disease
ID BREAST-CANCER CELLS; SERUM LEPTIN LEVELS; ERECTILE DYSFUNCTION;
   SEX-HORMONES; RECEPTOR-ALPHA; NONGENOMIC ACTIONS; RISK-FACTORS;
   ENDOCRINE DISRUPTORS; MESSENGER-RNA; BODY-FAT
AB For some years now, reduced testosterone levels have been related to obesity, insulin resistance, type 2 diabetes, heart disease, benign prostatic hypertrophy and even prostate cancer - often considered guilty more by association, than actual cause - with little attention paid to the important role of increased intracellular oestrogen, in the pathogenesis of these chronic diseases.
   In the final stage of the steroidogenic cascade, testosterone is metabolised to oestradiol by P450 aromatase, in the cytoplasm of adipocytes, breast cells, endothelial cells and prostate cells, to increase intracellular oestradiol concentration at the expense of testosterone.
   It follows therefore, that any compound that up-regulates aromatase, or any molecule that mimics oestrogen, will not only increase the activation of the mainly proliferative, classic ER-alpha, oestrogen receptors to induce adipogenesis and growth disorders in oestrogen-sensitive tissues, but also activate the recently identified transmembrane G protein-coupled oestrogen receptors (GPER), and deleteriously alter important intracellular signalling sequences, that promote mitogenic growth and endothelial damage.
   This paper simplifies how stress, xeno-oestrogens, poor dietary choices and reactive toxins up-regulate aromatase to increase intracellular oestradiol production; how oestradiol in combination with leptin and insulin cause insulin resistance and leptin resistance through aberrant serine phosphorylation; how the increased oestradiol, insulin and leptin stimulate rapid, non-genomic G protein-coupled phosphorylation cascades, to increase fat deposition and create the vasoconstrictive, dyslipidemic features of metabolic syndrome; how aberrant GPER signalling induces benign prostatic hypertrophy; and how increased intracellular oestradiol stimulates mitogenic change and tumour-cell activators, to cause prostate cancer.
   In essence, the up-regulation of aromatase produces increased intracellular oestradiol, increases ER-alpha activation and increases GPER activation, in combination with insulin, to cause aberrant downstream transduction signaling, and thus induce metabolic syndrome and mitogenic prostate growth.
   To understand this fact, that raised intracellular oestradiol levels in men, induce and promote obesity, gynecomastia, metabolic syndrome, type two diabetes, benign prostatic hypertrophy and prostate cancer, rather than low testosterone, represents a shift in medical thinking, a new awareness, that will reduce the rising incidence of obesity, metabolic syndrome and prostate disease, and significantly improve the health of men worldwide. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
C1 Metab Endocrinol & Clin Res, Noosa Heads, Qld 4567, Australia.
RP Williams, G (corresponding author), Metab Endocrinol & Clin Res, POB 1574, Noosa Heads, Qld 4567, Australia.
EM graemewilliams8@bigpond.com
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   World Health Organisation Global Infobase, 2004, WHO GLOB INF 2004 20
NR 109
TC 86
Z9 91
U1 0
U2 19
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0303-7207
J9 MOL CELL ENDOCRINOL
JI Mol. Cell. Endocrinol.
PD APR 4
PY 2012
VL 351
IS 2
BP 269
EP 278
DI 10.1016/j.mce.2011.12.017
PG 10
WC Cell Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Endocrinology & Metabolism
GA 913VW
UT WOS:000301906500014
PM 22233684
DA 2025-06-11
ER

PT J
AU Abe, K
   Kuo, L
   Zukowska, Z
AF Abe, Ken
   Kuo, Lydia
   Zukowska, Zofia
TI Neuropeptide Y is a mediator of chronic vascular and metabolic
   maladaptations to stress and hypernutrition
SO EXPERIMENTAL BIOLOGY AND MEDICINE
LA English
DT Article; Proceedings Paper
CT Annual FASEB Experimental Biology Meeting
CY APR 21, 2009
CL San Diego, CA
DE atherosclerosis; cardiovascular disease; metabolic syndrome;
   neuropeptide Y; obesity; stress
ID SMOOTH-MUSCLE-CELLS; RAT CAROTID-ARTERY; ADIPOSE-TISSUE;
   SYMPATHETIC-NERVES; NERVOUS-SYSTEM; MESSENGER-RNA; IMMUNE-SYSTEM;
   BONE-MARROW; COLD STRESS; NPY
AB Neuropeptide Y (NPY) is a central neuromodulator and peripheral sympathetic neurotransmitter that also has important regulatory roles in cardiovascular, neuroendocrine, immune and metabolic functions during stress. Focusing on the peripheral actions of the peptide in rodent models, we summarize recent studies from our laboratory demonstrating that stress-induced release of NPY mediates accelerated atherosclerosis/restenosis, obesity and metabolic-like syndrome, particularly when combined with a high fat, high sugar diet. In this review, we propose mechanisms of NPY's actions, its receptors and cellular substrates that increase the risk for cardiovascular and metabolic diseases when chronic stress is associated with pre-existing vascular injury and/or states of hypernutrition.
C1 [Abe, Ken; Kuo, Lydia; Zukowska, Zofia] Georgetown Univ, Med Ctr, Dept Physiol & Biophys, Washington, DC 20057 USA.
C3 Georgetown University
RP Zukowska, Z (corresponding author), Georgetown Univ, Med Ctr, Dept Physiol & Biophys, 3900 Reservoir Rd NW, Washington, DC 20057 USA.
EM zzukow01@georgetown.edu
FU NHLBI NIH HHS [5R01HL067357-09] Funding Source: Medline
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NR 51
TC 27
Z9 31
U1 0
U2 3
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1535-3702
EI 1535-3699
J9 EXP BIOL MED
JI Exp. Biol. Med.
PD OCT
PY 2010
VL 235
IS 10
BP 1179
EP 1184
DI 10.1258/ebm.2010.009136
PG 6
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Research & Experimental Medicine
GA 670VN
UT WOS:000283455500006
PM 20881322
DA 2025-06-11
ER

PT J
AU Pignatelli, P
   Menichelli, D
   Pastori, D
   Violi, F
AF Pignatelli, Pasquale
   Menichelli, Danilo
   Pastori, Daniele
   Violi, Francesco
TI Oxidative stress and cardiovascular disease: new insights
SO KARDIOLOGIA POLSKA
LA English
DT Review
DE oxidative stress; cardiovascular diseases; NADPH oxidase
ID LOW-DENSITY-LIPOPROTEIN; CORONARY-ARTERY-DISEASE;
   EXTRACELLULAR-SUPEROXIDE DISMUTASE; NITRIC-OXIDE SYNTHASE; NADPH
   OXIDASE; OXIDIZED LDL; LIPID-PEROXIDATION; MEDITERRANEAN DIET;
   HEART-DISEASE; INDEPENDENT PREDICTOR
AB The role of oxidative stress in the onset and progression of atherosclerosis and its impact on the development of cardiovascular events has been widely described.
   Thus, increased oxidative stress has been described in several atherosclerotic risk factors, such as hypertension, dyslipidaemia, peripheral artery disease, metabolic syndrome, diabetes, and obesity.
   Among others, specific oxidative pathways involving both pro-oxidant and antioxidant enzymes seem to play a major role in the production of reactive oxidant species (ROS), such as nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, myeloperoxidase, superoxide dismutase, and glutathione peroxidase.
   In this review, we will discuss: 1) the most relevant enzyme systems involved in the formation and detoxification of ROS, 2) the relationship between oxidative stress and cardiovascular risk, and 3) therapeutic implications to modulate oxidative stress.
C1 [Pignatelli, Pasquale; Menichelli, Danilo; Pastori, Daniele; Violi, Francesco] Sapienza Univ Rome, Atherothrombosis Ctr, Clin Med 1, Dept Internal Med & Med Specialties, Rome, Italy.
C3 Sapienza University Rome
RP Violi, F (corresponding author), 1 Clin Med, Viale Policlin 155, I-00161 Rome, Italy.
EM francesco.violi@uniroma1.it
RI Violi, Francesco/K-1509-2016; pastori, daniele/J-7087-2016; Menichelli,
   Danilo/W-5498-2018; pignatelli, pasquale/K-2116-2016
OI pastori, daniele/0000-0001-6357-5213; Menichelli,
   Danilo/0000-0001-9467-5903; pignatelli, pasquale/0000-0002-2265-7455
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NR 100
TC 160
Z9 173
U1 6
U2 78
PU POLISH CARDIAC SOC-POLSKIE TOWARZYSTWO KARDIOLOGICZNE
PI WARSZAWA
PA UL STAWKI 3 A LOK 1-2, WARSZAWA, POLAND
SN 0022-9032
EI 1897-4279
J9 KARDIOL POL
JI Kardiol. Pol.
PY 2018
VL 76
IS 4
BP 713
EP 722
DI 10.5603/KP.a2018.0071
PG 10
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA GC8KC
UT WOS:000430041800004
PM 29537483
DA 2025-06-11
ER

PT J
AU Beebe-Dimmer, JL
   Ruterbusch, JJ
   Harper, FWK
   Baird, TM
   Finlay, DG
   Rundle, AG
   Pandolfi, SS
   Hastert, TA
   Schwartz, KL
   Bepler, G
   Simon, MS
   Mantey, J
   Abrams, J
   Albrecht, TL
   Schwartz, AG
AF Beebe-Dimmer, Jennifer L.
   Ruterbusch, Julie J.
   Harper, Felicity W. K.
   Baird, Tara M.
   Finlay, David G.
   Rundle, Andrew G.
   Pandolfi, Stephanie S.
   Hastert, Theresa A.
   Schwartz, Kendra L.
   Bepler, Gerold
   Simon, Michael S.
   Mantey, Julia
   Abrams, Judy
   Albrecht, Teri L.
   Schwartz, Ann G.
TI Physical activity and quality of life in African American cancer
   survivors: The Detroit Research on Cancer Survivors study
SO CANCER
LA English
DT Article
DE anxiety; breast cancer; colorectal cancer; depression; exercise; health
   disparities; lung cancer; prostate cancer
ID BREAST-CANCER; METABOLIC SYNDROME; CARDIOVASCULAR-DISEASE; INDUCED
   CARDIOTOXICITY; TUMOR CHARACTERISTICS; RACIAL DISPARITIES; ETHNIC
   DISPARITIES; RISK; METAANALYSIS; RELIABILITY
AB Background The benefit of regular exercise in improving cancer outcomes is well established. The American Cancer Society (ACS) released a recommendation that cancer survivors should engage in at least 150 minutes of moderate to vigorous physical activity (PA) per week; however, few report meeting this recommendation. This study examined the patterns and correlates of meeting ACS PA recommendations in the Detroit Research on Cancer Survivors (ROCS) cohort of African American cancer survivors.
   Methods Detroit ROCS participants completed baseline and yearly follow-up surveys to update their health and health behaviors, including PA. This study examined participation in PA by select characteristics and reported health-related quality of life (HRQOL) as measured with the Functional Assessment of Cancer Therapy and Patient-Reported Outcomes Measurement Information System instruments.
   Results Among the first 1500 ROCS participants, 60% reported participating in regular PA, with 24% reporting >= 150 min/wk. Although there were no differences by sex, prostate cancer survivors were the most likely to report participating in regular PA, whereas lung cancer survivors were the least likely (P = .022). Survivors who reported participating in regular PA reported higher HRQOL (P < .001) and lower depression (P = .040).
   Conclusions Just 24% of African American cancer survivors reported meeting the ACS guidelines for PA at the baseline, but it was encouraging to see increases in activity over time. Because of the established benefits of regular exercise observed in this study and others, identifying and reducing barriers to regular PA among African American cancer survivors are critical for improving outcomes and minimizing disparities.
C1 [Beebe-Dimmer, Jennifer L.; Ruterbusch, Julie J.; Harper, Felicity W. K.; Baird, Tara M.; Finlay, David G.; Pandolfi, Stephanie S.; Hastert, Theresa A.; Schwartz, Kendra L.; Bepler, Gerold; Simon, Michael S.; Mantey, Julia; Abrams, Judy; Albrecht, Teri L.; Schwartz, Ann G.] Barbara Ann Karmanos Canc Inst, 4100 John R St, Detroit, MI 48201 USA.
   [Beebe-Dimmer, Jennifer L.; Ruterbusch, Julie J.; Harper, Felicity W. K.; Baird, Tara M.; Pandolfi, Stephanie S.; Hastert, Theresa A.; Schwartz, Kendra L.; Bepler, Gerold; Simon, Michael S.; Mantey, Julia; Abrams, Judy; Albrecht, Teri L.; Schwartz, Ann G.] Wayne State Sch Med, Dept Oncol, Detroit, MI USA.
   [Rundle, Andrew G.] Columbia Univ, Mailman Sch Publ Hlth, New York, NY USA.
C3 Barbara Ann Karmanos Cancer Institute; Wayne State University; Columbia
   University
RP Beebe-Dimmer, JL (corresponding author), Barbara Ann Karmanos Canc Inst, 4100 John R St, Detroit, MI 48201 USA.
EM dimmerj@karmanos.org
RI Harper, Felicity/AAE-3601-2019; Rundle, Andrew/A-5282-2009
OI Rundle, Andrew/0000-0003-0211-7707
FU National Cancer Institute of the National Institutes of Health [U01
   CA199240, P30 CA022453]; Barbara Ann Karmanos Cancer Institute;
   Metropolitan Detroit Cancer Surveillance System (Detroit Surveillance,
   Epidemiology, and End Results Cancer Registry) [HHSN-261201300011I];
   General Motors Foundation
FX This work was supported by the National Cancer Institute of the National
   Institutes of Health (U01 CA199240 and P30 CA022453), the Barbara Ann
   Karmanos Cancer Institute, the Metropolitan Detroit Cancer Surveillance
   System (Detroit Surveillance, Epidemiology, and End Results Cancer
   Registry contract HHSN-261201300011I), and the General Motors
   Foundation.
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NR 45
TC 35
Z9 38
U1 5
U2 35
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0008-543X
EI 1097-0142
J9 CANCER-AM CANCER SOC
JI Cancer
PD JAN 1
PY 2020
VL 126
IS 9
BP 1987
EP 1994
DI 10.1002/cncr.32725
EA FEB 2020
PG 8
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Oncology
GA LC6DN
UT WOS:000515116100001
PM 32090322
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Cano-Ibáñez, N
   Serra-Majem, L
   Martín-Peláez, S
   Martínez-González, MA
   Salas-Salvadó, J
   Piquer, MDC
   Lassale, C
   Hernandez, JAM
   Alonso-Gómez, AM
   Wärnberg, J
   Lopez, JV
   Romaguera, D
   López-Miranda, J
   Estruch, R
   Gómez-Pérez, AM
   Santos-Lozano, JM
   Fernández-Aranda, F
   Bueno-Cavanillas, A
   Tur, JA
   Martín, V
   Sala, XP
   Delgado-Rodríguez, M
   Martín, PM
   Vidal, J
   Cárdenas, JJ
   Ruiz, LD
   Ros, E
   Buil-Cosiales, P
   Becerra-Tomás, N
   Saiz, C
   Muñoz-Perez, MA
   Abete, I
   Tojal-Sierra, L
   Fernández-Barceló, O
   Bernabé-Casanova, A
   Konieczna, J
   García-Ríos, A
   Casas, R
   Bernal-López, MR
   Lapetra, J
   Toledo, E
   Gómez-Martínez, C
   Coltell, O
   Malcampo-Manrúbia, M
   Zulet, MA
   Sorto-Sánchez, C
   Gea, A
   Hernández-Fleta, JL
   Niño, OC
   Sánchez-Villegas, A
AF Cano-Ibanez, Naomi
   Serra-Majem, Lluis
   Martin-Pelaez, Sandra
   Angel Martinez-Gonzalez, Miguel
   Salas-Salvado, Jordi
   Corella Piquer, Maria Dolores
   Lassale, Camille
   Martinez Hernandez, Jose Alfredo
   Alonso-Gomez, Angel M.
   Warnberg, Julia
   Vioque Lopez, Jesus
   Romaguera, Dora
   Lopez-Miranda, Jose
   Estruch, Ramon
   Maria Gomez-Perez, Ana
   Manuel Santos-Lozano, Jose
   Fernandez-Aranda, Fernando
   Bueno-Cavanillas, Aurora
   Tur, Josep A.
   Martin, Vicente
   Pinto Sala, Xavier
   Delgado-Rodriguez, Miguel
   Matia Martin, Pilar
   Vidal, Josep
   Cardenas, Jersy J.
   Daimiel Ruiz, Lidia
   Ros, Emilio
   Buil-Cosiales, Pilar
   Becerra-Tomas, Nerea
   Saiz, Carmen
   Munoz-Perez, Miguel-Angel
   Abete, Itziar
   Tojal-Sierra, Lucas
   Fernandez-Barcelo, Olga
   Bernabe-Casanova, Andrea
   Konieczna, Jadwiga
   Garcia-Rios, Antonio
   Casas, Rosa
   Rosa Bernal-Lopez, Maria
   Lapetra, Jose
   Toledo, Estefania
   Gomez-Martinez, Carlos
   Coltell, Oscar
   Malcampo-Manrubia, Mireia
   Angeles Zulet, Maria
   Sorto-Sanchez, Carolina
   Gea, Alfredo
   Luis Hernandez-Fleta, Jose
   Castaner Nino, Olga
   Sanchez-Villegas, Almudena
TI Association between the Prime Diet Quality Score and depressive symptoms
   in a Mediterranean population with metabolic syndrome. Cross-sectional
   and 2-year follow-up assessment from PREDIMED-PLUS study
SO BRITISH JOURNAL OF NUTRITION
LA English
DT Article
DE Prime diet quality score; Depressive symptomatology; Metabolic syndrome;
   PREDIMED-plus study
ID PHYSICAL-ACTIVITY QUESTIONNAIRE; FOOD FREQUENCY QUESTIONNAIRE; PATTERNS;
   RISK; VALIDATION; DISEASE; METAANALYSIS; NUTRIENTS; BURDEN; BRAIN
AB The burden of depression is increasing worldwide, specifically in older adults. Unhealthy dietary patterns may partly explain this phenomenon. In the Spanish PREDIMED-Plus study, we explored (1) the cross-sectional association between the adherence to the Prime Diet Quality Score (PDQS), an a priori-defined high-quality food pattern, and the prevalence of depressive symptoms at baseline (cross-sectional analysis) and (2) the prospective association of baseline PDQS with changes in depressive symptomatology after 2 years of follow-up. After exclusions, we assessed 6612 participants in the cross-sectional analysis and 5523 participants in the prospective analysis. An energy-adjusted high-quality dietary score (PDQS) was assessed using a validated FFQ. The cross-sectional association between PDQS and the prevalence of depression or presence of depressive symptoms and the prospective changes in depressive symptoms were evaluated through multivariable regression models (logistic and linear models and mixed linear-effects models). PDQS was inversely associated with depressive status in the cross-sectional analysis. Participants in the highest quintile of PDQS (Q5) showed a significantly reduced odds of depression prevalence as compared to participants in the lowest quartile of PDQS (Q1) (OR (95 %) CI = 0 center dot 82 (0 center dot 68, 0 center dot 98))). The baseline prevalence of depression decreased across PDQS quintiles (P (for trend) = 0 center dot 015). A statistically significant association between PDQS and changes in depressive symptoms after 2-years follow-up was found (beta (95 %) CI = -0 center dot 67 z-score (-1 center dot 17, -0 center dot 18). A higher PDQS was cross-sectionally related to a lower depressive status. Nevertheless, the null finding in our prospective analysis raises the possibility of reverse causality. Further prospective investigation is required to ascertain the association between PDQS and changes in depressive symptoms along time.
C1 [Cano-Ibanez, Naomi; Martin-Pelaez, Sandra; Bueno-Cavanillas, Aurora] Univ Granada, Dept Prevent Med & Publ Hlth, Granada, Spain.
   [Cano-Ibanez, Naomi; Vioque Lopez, Jesus; Bueno-Cavanillas, Aurora; Martin, Vicente; Delgado-Rodriguez, Miguel; Buil-Cosiales, Pilar] Inst Hlth Carlos III, Ctr Invest Biomed Red Epidemiol & Salud Publ CIBE, Madrid, Spain.
   [Cano-Ibanez, Naomi; Martin-Pelaez, Sandra; Bueno-Cavanillas, Aurora] Inst Invest Biosanit Granada Ibs GRANADA, Granada, Spain.
   [Serra-Majem, Lluis; Angel Martinez-Gonzalez, Miguel; Salas-Salvado, Jordi; Corella Piquer, Maria Dolores; Lassale, Camille; Alonso-Gomez, Angel M.; Warnberg, Julia; Romaguera, Dora; Lopez-Miranda, Jose; Estruch, Ramon; Maria Gomez-Perez, Ana; Manuel Santos-Lozano, Jose; Fernandez-Aranda, Fernando; Tur, Josep A.; Pinto Sala, Xavier; Ros, Emilio; Becerra-Tomas, Nerea; Saiz, Carmen; Abete, Itziar; Tojal-Sierra, Lucas; Fernandez-Barcelo, Olga; Konieczna, Jadwiga; Garcia-Rios, Antonio; Casas, Rosa; Rosa Bernal-Lopez, Maria; Lapetra, Jose; Toledo, Estefania; Gomez-Martinez, Carlos; Coltell, Oscar; Angeles Zulet, Maria; Sorto-Sanchez, Carolina; Gea, Alfredo; Sanchez-Villegas, Almudena] Inst Salud Carlos III ISCIII, MP Fisiopatol Obesidad & Nutr CIBERobn, Consorcio CIBER, Madrid, Spain.
   [Serra-Majem, Lluis; Sanchez-Villegas, Almudena] Univ Las Palmas Gran Canaria, Res Inst Biomed & Hlth Sci IUIBS, Las Palmas Gran Canaria, Spain.
   [Angel Martinez-Gonzalez, Miguel; Buil-Cosiales, Pilar; Abete, Itziar; Toledo, Estefania; Angeles Zulet, Maria; Gea, Alfredo] Univ Navarra, Dept Prevent Med & Publ Hlth, IDISNA, Pamplona, Spain.
   [Angel Martinez-Gonzalez, Miguel] Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA.
   [Salas-Salvado, Jordi; Becerra-Tomas, Nerea; Gomez-Martinez, Carlos] Univ Rovira & Virgili, Dept Bioquim & Biotecnol, Unitat Nutr Humana, Reus, Spain.
   [Salas-Salvado, Jordi; Becerra-Tomas, Nerea; Gomez-Martinez, Carlos] Hosp Univ San Joan Reus, Human Nutr Unit, Reus, Spain.
   [Salas-Salvado, Jordi; Becerra-Tomas, Nerea; Gomez-Martinez, Carlos] Inst Invest Sanitaria Pere Virgili IISPV, Reus, Spain.
   [Corella Piquer, Maria Dolores; Saiz, Carmen] Univ Valencia, Dept Prevent Med, Valencia, Spain.
   [Lassale, Camille; Malcampo-Manrubia, Mireia; Castaner Nino, Olga] Hosp del Mar Med Res Inst IMIM, Cardiovasc Risk & Nutr Res Grp, Barcelona, Spain.
   [Martinez Hernandez, Jose Alfredo; Abete, Itziar; Angeles Zulet, Maria] Univ Navarra, Ctr Nutr Res, Dept Nutr Food Sci & Physiol, IdisNA, Pamplona, Spain.
   [Martinez Hernandez, Jose Alfredo; Daimiel Ruiz, Lidia] CEI UAM CSIC, Nutr Control Epigenome Precis Nutr & Obes Program, Madrid, Spain.
   [Alonso-Gomez, Angel M.; Tojal-Sierra, Lucas; Sorto-Sanchez, Carolina] Univ Basque Country UPV EHU, Araba Univ Hosp, Bioaraba Hlth Res Inst, Cardiovasc Resp & Metab Area,Osakidetza Basque Hl, Vitoria, Spain.
   [Warnberg, Julia; Fernandez-Barcelo, Olga] Univ Malaga, Sch Hlth Sci, Dept Nursing, Inst Invest Biomed Malaga IBIMA, Malaga, Spain.
   [Vioque Lopez, Jesus] Inst Invest Sanitario & Biomed Alicante, ISABIAL UMH, Alicante, Spain.
   [Romaguera, Dora; Konieczna, Jadwiga] Hlth Res Inst Balearic Isl IdISBa, Palma De Mallorca, Spain.
   [Lopez-Miranda, Jose; Garcia-Rios, Antonio] Univ Cordoba, Reina Sofia Univ Hosp, Maimonides Biomed Res Inst Cordoba IMIBIC, Dept Internal Med, Cordoba, Spain.
   [Estruch, Ramon; Casas, Rosa] Univ Barcelona, Hosp Clin, Inst Invest Biomed August Pi Sunyer IDIBAPS, Dept Internal Med, Barcelona, Spain.
   [Maria Gomez-Perez, Ana; Rosa Bernal-Lopez, Maria] Univ Malaga, Virgen de la Victoria Hosp, Inst Invest Biomed Malga IBIMA, Dept Endocrinol, Malaga, Spain.
   [Manuel Santos-Lozano, Jose; Lapetra, Jose] Dist Sanitario Atenc Primaria Sevilla, Res Unit, Dept Family Med, Seville, Spain.
   [Fernandez-Aranda, Fernando] Univ Barcelona, Univ Hosp Bellvitge IDIBELL, Dept Psychiat, Barcelona, Spain.
   [Fernandez-Aranda, Fernando] Univ Barcelona, Sch Med & Hlth Sci, Barcelona, Spain.
   [Tur, Josep A.] Univ Balearic Isl, Res Grp Community Nutr & Oxidat Stress, Palma De Mallorca, Spain.
   [Martin, Vicente] Univ Leon, Inst Biomed IBIOMED, Leon, Spain.
   [Pinto Sala, Xavier] Hosp Univ Bellvitge, Lipids & Vasc Risk Unit, Internal Med, Barcelona, Spain.
   [Delgado-Rodriguez, Miguel] Univ Jaen, Ctr Adv Studies Olive Grove & Olive Oils, Jaen, Spain.
   [Matia Martin, Pilar] Inst Invest Sanitaria Hosp Clin San Carlos IdISSC, Dept Endocrinol & Nutr, Madrid, Spain.
   [Vidal, Josep] Inst Salud Carlos III ISCIII, CIBER Diabet & Enfermedades Metab CIBERDEM, Madrid, Spain.
   [Vidal, Josep] Univ Barcelona, Hosp Clin, Inst Invest Biomed August Pi Sunyer IDIBAPS, Dept Endocrinol, Barcelona, Spain.
   [Cardenas, Jersy J.] Univ Autonoma, Hosp Fdn Jimenez Diaz, Inst Invest Biomed IISFJD, Dept Endocrinol & Nutr, Madrid, Spain.
   [Ros, Emilio] Hosp Clin Barcelona, Inst Invest Biomed August Pi Sunyer IDIBAPS, Dept Endocrinol & Nutr, Lipid Clin, Barcelona, Spain.
   [Buil-Cosiales, Pilar] Inst Invest Sanitaria Navarra IdiSNA, Serv Navarro Salud Osasunbidea, Pamplona, Navarra, Spain.
   [Munoz-Perez, Miguel-Angel] Inst Catala Salut, Primary Care Div, Unitat Suport Recerca Atencio Primaria Barcelona, IDIAP Jordi Gol, Barcelona, Spain.
   [Bernabe-Casanova, Andrea] Ctr Salud Raval Elche, Alicante, Spain.
   [Coltell, Oscar] Univ Jaume 1, Dept Comp Languages & Syst, Castellon de La Plana, Spain.
   [Luis Hernandez-Fleta, Jose] Hosp Dr Negrin, Psychiat Serv, Las Palmas Gran Canaria, Spain.
   [Sanchez-Villegas, Almudena] Univ Publ Navarra UPNA, ISFOOD Inst Innovat & Sustainable Dev Food Chain, Inst Invest Sanitaria Navarra, IdiSNA, Pamplona, Spain.
C3 University of Granada; CIBER - Centro de Investigacion Biomedica en Red;
   CIBERESP; Instituto de Investigacion Biosanitaria IBS Granada;
   Universidad de Las Palmas de Gran Canaria; University of Navarra;
   Harvard University; Harvard T.H. Chan School of Public Health;
   Universitat Rovira i Virgili; Universitat Rovira i Virgili; Institut
   d'Investigacio Sanitaria Pere Virgili (IISPV); University of Valencia;
   Hospital del Mar Research Institute; Hospital del Mar; University of
   Navarra; Consejo Superior de Investigaciones Cientificas (CSIC);
   Bioaraba Health Research Institute; University Hospital of Araba;
   University of Basque Country; Instituto de Investigacion Biomedica de
   Malaga y Plataforma en Nanomedicina (IBIMA); Universidad de Malaga;
   General University Hospital of Alicante; Universidad Miguel Hernandez de
   Elche; Universitat d'Alacant; Instituto de Investigacion Sanitaria y
   Biomedica de Alicante (ISABIAL); Institut Investigacio Sanitaria Illes
   Balears (IdISBa); Universidad de Cordoba; University of Barcelona;
   Hospital Clinic de Barcelona; IDIBAPS; Universidad de Malaga; Instituto
   de Investigacion Biomedica de Malaga y Plataforma en Nanomedicina
   (IBIMA); University of Barcelona; Institut d'Investigacio Biomedica de
   Bellvitge (IDIBELL); Bellvitge University Hospital; University of
   Barcelona; Universitat de les Illes Balears; Universidad de Leon;
   Institut d'Investigacio Biomedica de Bellvitge (IDIBELL); Bellvitge
   University Hospital; University of Barcelona; Universidad de Jaen; CIBER
   - Centro de Investigacion Biomedica en Red; CIBERDEM; University of
   Barcelona; Hospital Clinic de Barcelona; IDIBAPS; Fundacion Jimenez
   Diaz; Autonomous University of Madrid; University of Barcelona; Hospital
   Clinic de Barcelona; IDIBAPS; Servicio Navarro de Salud - Osasunbidea;
   Universitat Jaume I; Universidad Publica de Navarra
RP Cano-Ibáñez, N (corresponding author), Univ Granada, Dept Prevent Med & Publ Hlth, Granada, Spain.; Cano-Ibáñez, N (corresponding author), Inst Hlth Carlos III, Ctr Invest Biomed Red Epidemiol & Salud Publ CIBE, Madrid, Spain.; Cano-Ibáñez, N (corresponding author), Inst Invest Biosanit Granada Ibs GRANADA, Granada, Spain.
EM ncaiba@ugr.es
RI Sureda, Antoni/N-9588-2019; Tur, Josep/AAE-5748-2020; Martinez,
   Sandra/HSG-4592-2023; Sanchez-Villegas, Almudena/T-6733-2019;
   Bueno-Cavanillas, Aurora/O-1513-2015; Rodríguez, Miguel/KCZ-1828-2024;
   MARTIN-PELAEZ, SANDRA/G-4945-2015; ALONSO GOMEZ, ANGEL/HLG-2476-2023;
   Pintó, Xavier/AGI-4297-2022; Coltell, Oscar/AAA-9936-2019; Hernández
   Fleta, Jose Luis/IUM-7005-2023; Lassale, Camille/ABE-7813-2020;
   Castaner, Olga/F-1533-2013; Fernández-Barceló, Olga/AAO-6485-2021;
   Estruch, Ramon/AAZ-3723-2020; Lopez-Miranda, Jose/Y-8306-2019;
   Romaguera, Dora/ABE-7004-2020; Toledo, Estefania/H-6211-2014; Lapetra,
   Jose/F-2552-2015; Vidal, Josep/MIK-6936-2025; Warnberg,
   Julia/G-1390-2011; Abad-Gurumeta, Alfredo/M-2337-2019; Konieczna,
   Jadwiga/AAB-2817-2020; Casas, Rosa/ABD-1915-2020; Martinez-Gonzalez,
   Miguel/AAE-7669-2019; Salas-Salvado, Jordi/C-7229-2017; Martin,
   Vicente/A-1597-2008; Becerra-Tomas, Nerea/H-3937-2018; FERNANDEZ-ARANDA,
   FERNANDO/L-9762-2014; Delgado Rodriguez, Miguel/H-4940-2017;
   Daimiel-Ruiz, Lidia Angeles/M-7779-2014; Gomez Martinez,
   Carlos/AGJ-6387-2022
OI Tojal Sierra, Lucas/0000-0001-5338-9601; Cano-Ibanez,
   Naomi/0000-0002-3640-5486; Salas-Salvado, Jordi/0000-0003-2700-7459;
   Martin, Vicente/0000-0003-0552-2804; Becerra-Tomas,
   Nerea/0000-0002-4429-6507; Buil-Cosiales, Pilar/0000-0002-8586-577X;
   FERNANDEZ-ARANDA, FERNANDO/0000-0002-2968-9898; Munoz,
   Miguel-Angel/0000-0002-4083-3248; Delgado Rodriguez,
   Miguel/0000-0002-3838-2548; MARTIN PELAEZ, SANDRA/0000-0002-2193-3913;
   Hernandez Fleta, Jose Luis/0000-0001-8083-9647; Lassale,
   Camille/0000-0002-9340-2708; Daimiel-Ruiz, Lidia
   Angeles/0000-0001-9898-6629; Casas, Rosa/0000-0002-0211-9166; Sanchez
   Villegas, Almudena/0000-0001-7733-9238; Lopez-Miranda,
   Jose/0000-0002-8844-0718; Fernandez-Barcelo, Olga/0000-0002-7629-627X;
   Cardenas, Jersy Jair/0000-0002-2485-484X; Gomez Martinez,
   Carlos/0000-0002-3077-6702
FU European Research Council [340918]; Spanish Government, ISCIII through
   the Fondo de Investigacion para la Salud (FIS); European Regional
   Development Fund [PI13/00673, PI13/00492, PI13/00272, PI13/01123,
   PI13/00462, PI13/00233, PI13/02184, PI13/00728, PI13/01090, PI13/01056,
   PI14/01722, PI14/00636, PI14/00618, PI14/00696, PI14/01206, PI14/01919,
   PI14/00853, PI14/01374, PI16/00473]; Especial Action Project entitled:
   'Implementacion y Evaluacion de una intervencion intensiva sobre la
   actividad fisica Cohorte PREDIMED-Plus' [2013ACUP00194]; Consejeria de
   Salud de la Junta de Andalucia [PI0458/2013, PS0358/2016, PI0137/2018];
   Generalitat Valenciana; SEMERGEN grant; CIBEROBN and FEDER funds
   [CB06/03]; International Nut&Dried Fruit Council-FESNAD [201302];
   Department of Health, Generalitt de Cataluna by the calls "Accio
   instrumental de programes de recerca orientatsenlambit de la recercaila
   innovacio en salut" [SLT006/17/00246]; Pla estrategic de recerca i
   innovacio en salut (PERIS) [SLT006/17/00246]; EU
   [Eat2beNICE/h2020-sfs-2016-2, 728,018, PRIME/h2020-SC1-BHC2018-2020,
   847,879]; The European Regional Development Fund [PI16/00662,
   PI16/01873, PI16/01094, PI16/00501, PI16/00533, PI16/00381, PI16/00366,
   PI16/01522, PI16/01120, PI17/00764, PI17/01183, PI17/00855, PI17/01347,
   PI17/00525, PI17/01827, PI17/00532, PI17/00215, PI17/01441, PI17/00508,
   PI17/01732, PI17/00926]
FX The PREDIMED-Plus trial was supported by the European Research Council
   (Advanced Research Grant 2013-2018; 340918) grant to Miguel Angel
   Martinez-Gonzalez and by the official funding agency for biomedical
   research of the Spanish Government, ISCIII through the Fondo de
   Investigacion para la Salud (FIS), which is co-funded by the European
   Regional Development Fund (four coordinated FIS projects led by Jordi
   Salas-Salvado and Josep Vidal), including the following projects:
   PI13/00673, PI13/00492, PI13/00272, PI13/01123, PI13/00462, PI13/00233,
   PI13/02184, PI13/00728, PI13/01090, PI13/01056, PI14/01722, PI14/00636,
   PI14/00618, PI14/00696, PI14/01206, PI14/01919, PI14/00853, PI14/01374,
   PI16/00473, PI16/00662, PI16/01873, PI16/01094, PI16/00501, PI16/00533,
   PI16/00381, PI16/00366, PI16/01522, PI16/01120, PI17/00764, PI17/01183,
   PI17/00855, PI17/01347, PI17/00525, PI17/01827, PI17/00532, PI17/00215,
   PI17/01441, PI17/00508, PI17/01732 and PI17/00926. The Especial Action
   Project entitled: 'Implementacion y Evaluacion de una intervencion
   intensiva sobre la actividad fisica Cohorte PREDIMED-Plus' grant to
   Jordi Salas-Salvado, the Recercaixa grant to Jordi Salas-Salvado
   (2013ACUP00194), grants from the Consejeria de Salud de la Junta de
   Andalucia (PI0458/2013; PS0358/2016; PI0137/2018), the PROMETEO/2017/017
   grant from the Generalitat Valenciana, the SEMERGEN grant and CIBEROBN
   and FEDER funds (CB06/03), ISCIII. International Nut&Dried Fruit
   Council-FESNAD N degrees 201302: Miguel Angel Martinez-Gonzalez (PI).
   None of the funding sources took part in the design, collection,
   analysis or interpretation of the data or in the decision to submit the
   manuscript for publication. Fernando Fernandez-Aranda and the study was
   partially funded by the following grants: SLT006/17/00246, by the
   Department of Health, Generalitt de Cataluna by the calls "Accio
   instrumental de programes de recerca orientatsenlambit de la recercaila
   innovacio en salut" and "Pla estrategic de recerca i innovacio en salut
   (PERIS)". We thank CERCA Programme/Generalitt de Catalunya for
   institutional support. This research was also partially funded by
   EU-H2020 Grants (Eat2beNICE/h2020-sfs-2016-2; ref.728,018; and
   PRIME/h2020-SC1-BHC2018-2020; ref: 847,879) The corresponding author had
   full access to all the data in the study and had final responsibility to
   submit for publication.
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   World Health Organization, 2017, Global Hepatitis Report 2017
NR 40
TC 12
Z9 12
U1 1
U2 17
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1145
EI 1475-2662
J9 BRIT J NUTR
JI Br. J. Nutr.
PD SEP 28
PY 2022
VL 128
IS 6
BP 1170
EP 1179
AR PII S0007114521004323
DI 10.1017/S0007114521004323
EA OCT 2021
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 3U1FJ
UT WOS:000744721900001
PM 34713791
DA 2025-06-11
ER

PT J
AU Patel, PJ
   Hayward, KL
   Rudra, R
   Horsfall, LU
   Hossain, F
   Williams, S
   Johnson, T
   Brown, NN
   Saad, N
   Clouston, AD
   Stuart, KA
   Valery, PC
   Irvine, KM
   Russell, AW
   Powell, EE
AF Patel, Preya Janubhai
   Hayward, Kelly Lee
   Rudra, Rathiga
   Horsfall, Leigh Ula
   Hossain, Fabrina
   Williams, Suzanne
   Johnson, Tracey
   Brown, Nigel Neil
   Saad, Nivene
   Clouston, Andrew Donald
   Stuart, Katherine Anne
   Valery, Patricia Casarolli
   Irvine, Katharine Margaret
   Russell, Anthony William
   Powell, Elizabeth Ellen
TI Multimorbidity and polypharmacy in diabetic patients with NAFLD:
   Implications for disease severity and management
SO MEDICINE
LA English
DT Article
DE cirrhosis; liver disease; steatohepatitis; steatosis; transient
   elastography
ID FATTY LIVER-DISEASE; PROTON PUMP INHIBITORS; NONALCOHOLIC
   STEATOHEPATITIS; SIGNIFICANT FIBROSIS; RISK; MELLITUS; THERAPY; INJURY;
   DEPRESSION; ANXIETY
AB An observational study describing the number and type of chronic conditions and medications taken by diabetic patients with NAFLD and identifying characteristics that may impact liver disease severity or clinical management.Adults with type 2 diabetes have a high prevalence of nonalcoholic fatty liver disease (NAFLD) and increased risk of developing advanced liver disease. Appropriate management should consider the characteristics of the diabetic NAFLD population, as comorbid conditions and medications may increase the complexity of treatment strategies.Diabetic patients with NAFLD at risk of clinically significant liver disease (as assessed by the FIB-4 or NAFLD fibrosis scores) were recruited consecutively from the Endocrine clinic or primary care. Medical conditions, medication history, anthropometric measurements, and laboratory tests were obtained during assessment. NAFLD severity was classified by transient elastography and liver ultrasound into no advanced disease (LSM< 8.2 kPa) or clinically significant liver disease (LSM 8.2 kPa).The most common coexistent chronic conditions were metabolic syndrome (94%), self-reported depression (44%), ischaemic heart disease (32%), and obstructive sleep apnoea (32%). Polypharmacy or hyperpolypharmacy was present in 59% and 31% of patients respectively. Elevated LSM (8.2 kPa) suggesting significant liver disease was present in 37% of this at-risk cohort. Increasing obesity and abdominal girth were both independently associated with likelihood of having significant liver disease.There is a high burden of multimorbidity and polypharmacy in diabetic NAFLD patients, highlighting the importance of multidisciplinary management to address their complex health care needs and ensure optimal medical treatment.
C1 [Patel, Preya Janubhai; Horsfall, Leigh Ula; Stuart, Katherine Anne; Powell, Elizabeth Ellen] Univ Queensland, Princess Alexandra Hosp, Dept Gastroenterol & Hepatol, Brisbane, Qld, Australia.
   [Patel, Preya Janubhai; Rudra, Rathiga; Horsfall, Leigh Ula; Clouston, Andrew Donald; Irvine, Katharine Margaret; Powell, Elizabeth Ellen] Univ Queensland, Ctr Liver Dis Res, Translat Res Inst, Sch Med, Brisbane, Qld, Australia.
   [Hayward, Kelly Lee] Univ Queensland, Sch Med, Brisbane, Qld, Australia.
   [Hayward, Kelly Lee] Princess Alexandra Hosp, Pharm Dept, Brisbane, Qld, Australia.
   [Hossain, Fabrina; Williams, Suzanne; Johnson, Tracey] Princess Alexandra Hosp, Inala Primary Care, Brisbane, Qld, Australia.
   [Brown, Nigel Neil] Princess Alexandra Hosp, Pathol Queensland, Brisbane, Qld, Australia.
   [Saad, Nivene] Princess Alexandra Hosp, Dept Radiol, Brisbane, Qld, Australia.
   [Valery, Patricia Casarolli] Princess Alexandra Hosp, QIMR Berghofer Med Res Inst, Brisbane, Qld, Australia.
   [Russell, Anthony William] Princess Alexandra Hosp, Dept Endocrinol, Brisbane, Qld, Australia.
C3 University of Queensland; Princess Alexandra Hospital; University of
   Queensland; University of Queensland; Princess Alexandra Hospital;
   Princess Alexandra Hospital; Princess Alexandra Hospital; Princess
   Alexandra Hospital; QIMR Berghofer Medical Research Institute; Princess
   Alexandra Hospital; Princess Alexandra Hospital
RP Powell, EE (corresponding author), Princess Alexandra Hosp, Dept Gastroenterol & Hepatol, Ipswich Rd, Woolloongabba, Qld 4102, Australia.
EM e.powell@uq.edu.au
RI Valery, Patricia/AAV-5448-2020; Clouston, Andrew/E-7199-2011; Valery,
   Patricia/G-6230-2013; Russell, Anthony/A-8807-2011; Powell,
   Elizabeth/B-4455-2011; Irvine, Katharine/A-5559-2011
OI Hayward, Kelly/0000-0001-6115-3420; Valery,
   Patricia/0000-0002-8823-3006; Russell, Anthony/0000-0003-4902-6693;
   Patel, Preya/0000-0002-2433-6794; Russell, Anthony/0000-0001-7886-8844;
   Powell, Elizabeth/0000-0001-5008-8061; Irvine,
   Katharine/0000-0002-6716-1605
FU Pathology Queensland-Study, Education and Research Trust Fund;
   Australian National Health and Medical Research Council [1083090]
FX This study was funded by the Pathology Queensland-Study, Education and
   Research Trust Fund.r PCV was supported by the Australian National
   Health and Medical Research Council (Career Development Fellowship
   #1083090).
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NR 51
TC 42
Z9 43
U1 0
U2 8
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD JUN
PY 2017
VL 96
IS 26
AR e6761
DI 10.1097/MD.0000000000006761
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA EZ8FB
UT WOS:000404958900002
PM 28658094
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Grover, S
   Chakrabarti, S
   Sahoo, S
AF Grover, Sandeep
   Chakrabarti, Subho
   Sahoo, Swapnajeet
TI Prevalence and clinical correlates of residual symptoms in remitted
   patients with bipolar disorder: An exploratory study
SO INDIAN JOURNAL OF PSYCHIATRY
LA English
DT Article
DE Bipolar disorder; depression; mania; residual symptoms
ID SUBSYNDROMAL DEPRESSIVE SYMPTOMS; TREATMENT ENHANCEMENT PROGRAM;
   RATING-SCALE; METABOLIC SYNDROME; SLEEP DISTURBANCE; NATURAL-HISTORY;
   ILLNESS COURSE; MOOD SYMPTOMS; CLOZAPINE; THERAPY
AB Objective: This cross-sectional study aimed to evaluate the prevalence and factors associated with residual symptoms (both depressive and manic) in subjects with bipolar disorder (BD). Materials and Methods: A total of 844 subjects diagnosed BD with an illness of 2 years' duration and minimum of two lifetime episodes and in clinical remission were evaluated for residual symptoms using Hamilton Depression Rating Scale (HAM-D) and Young Mania Rating Scale (YMRS). Based on the severity of residual symptoms, the study groups were divided into four groups. Results: Sixty-nine percent of the subjects had residual depressive symptoms (i.e., HAM-D score in the range of 1-7) and 59% had residual manic symptoms (i.e., YMRS score in the range of 1-7). The most common residual depressive symptom was psychic anxiety (34%) followed by impaired insight (29%). The most common manic symptom was poor insight (31%) followed by sleep disturbances (25%). Subjects with both sets of residual symptoms had onset of BD at a relatively young age, when compared to those with only residual depressive symptoms. Presence of any comorbid physical illness and substance abuse disorder was significantly higher in those with both sets of residual symptoms. Conclusions: The present study suggests that a substantial proportion of patients with BD have residual symptoms of both types. Comorbid physical illness and substance use were associated with residual symptoms. Identification and management of residual symptoms are highly essential to improve the overall outcome of patients with BD.
C1 [Grover, Sandeep; Chakrabarti, Subho; Sahoo, Swapnajeet] Postgrad Inst Med Educ & Res, Dept Psychiat, Chandigarh 160012, India.
C3 Post Graduate Institute of Medical Education & Research (PGIMER),
   Chandigarh
RP Grover, S (corresponding author), Postgrad Inst Med Educ & Res, Dept Psychiat, Chandigarh 160012, India.
EM drsandeepg2002@yahoo.com
RI Grover, Sandeep/U-5297-2019; SAHOO, SWAPNAJEET/AAZ-5445-2020
OI chakrabarti, subho/0000-0001-6023-2194; Grover,
   Sandeep/0000-0002-2714-2055
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NR 61
TC 14
Z9 14
U1 0
U2 1
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, Maharashtra, INDIA
SN 0019-5545
EI 1998-3794
J9 INDIAN J PSYCHIAT
JI Indian J. Psychiatry
PD MAY-JUN
PY 2020
VL 62
IS 3
BP 295
EP 305
DI 10.4103/psychiatry.IndianJPsychiatry_760_19
PG 11
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA LT7TA
UT WOS:000537267800011
PM 32773873
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Raue, S
   Wedekind, D
   Wiltfang, J
   Schmidt, U
AF Raue, Stefan
   Wedekind, Dirk
   Wiltfang, Jens
   Schmidt, Ulrike
TI The Role of Proopiomelanocortin and α-Melanocyte-Stimulating Hormone in
   the Metabolic Syndrome in Psychiatric Disorders: A Narrative Mini-Review
SO FRONTIERS IN PSYCHIATRY
LA English
DT Review
DE posttraumatic stress disorder; schizophrenia; metabolic syndrome; HPA
   axis; proopiomelanocortin (POMC); PTSD; melanocyte stimulating hormone
   (MSH)
ID POSTTRAUMATIC-STRESS-DISORDER; MAJOR DEPRESSIVE DISORDER; INDUCED
   WEIGHT-GAIN; PHYSICAL ILLNESS; BIPOLAR DISORDER; SCHIZOPHRENIA; OBESITY;
   PREVALENCE; RECEPTOR; OVERWEIGHT
AB The metabolic syndrome (MetS) comprises abdominal obesity, preclinical or full diabetes type 2, arterial hypertension, and dyslipidemia and affects a significant proportion of the general population with a remarkably higher prevalence in patients suffering from psychiatric disorders. However, studies exploring the pathogenetic link between MetS and psychiatric diseases are rare. Here, we aim to narrow this gap in knowledge by providing a narrative review on this topic that focuses on two psychiatric diseases, namely on schizophrenia and posttraumatic stress disorder (PTSD) since we assume them to be associated with two different main causalities of MetS: in schizophrenia, MetS evidently develops or aggravates in response to antipsychotic drug treatment while it assumingly develops in response to stress-induced endocrine and/or epigenetic alterations in PTSD. First, we compared the prevalences of MetS and associated pathologies (which we took from the latest meta-analyses) among different psychiatric disorders and were surprised that the prevalences of arterial hypertension and hyperglycemia in PTSD almost doubles those of the other psychiatric disorders. Next, we performed a literature search on the neurobiology of MetS and found numerous articles describing a role for proopiomelanocortin (POMC) in MetS. Thus, we concentrated further analysis on POMC and one of its downstream effector hormones, alpha-melanocyte-stimulating hormone (alpha-MSH). We found some evidence for a role of POMC in both PTSD and schizophrenia, in particular in antipsychotic-induced MetS, as well as for alpha-MSH in schizophrenia, but, surprisingly, no study on alpha-MSH in PTSD. Taken together, our synopsis reveals, first, a potential interaction between the POMC system and stress in the assumingly at least partially shared pathogenesis of psychiatric disorders and MetS, second, that modulation of the POMC system, in particular of the melanocortin 3 and 4 receptors, might be a promising target for the treatment of MetS and, third, that the DNA methylation status of POMC might speculatively be a promising biomarker for MetS in general and, possibly, in particular in the context of stress-related psychiatric conditions such as PTSD. To best of our knowledge, this is the first review on the role of the POMC system in MetS in psychiatric disorders.
C1 [Raue, Stefan; Schmidt, Ulrike] Univ Med Ctr Gottingen UMG, Psychotrauma Treatment Unit, Gottingen, Germany.
   [Raue, Stefan; Schmidt, Ulrike] Univ Med Ctr Gottingen UMG, RG Stress Modulat Neurodegenerat, Dept Psychiat & Psychotherapy, Gottingen, Germany.
   [Wedekind, Dirk; Wiltfang, Jens] Georg August Univ Univ, Med Ctr Gottingen, Dept Psychiat & Psychotherapy, Gottingen, Germany.
   [Wiltfang, Jens] German Ctr Neurodegenerat Dis DZNE, Gottingen, Germany.
   [Wiltfang, Jens] Univ Aveiro, Dept Med Sci, IBiMED, Aveiro, Portugal.
   [Schmidt, Ulrike] Maastricht Univ, Med Ctr, Dept Psychiat & Neuropsychol, Sch Mental Hlth & Neurosci MHeNs, Maastricht, Netherlands.
C3 Helmholtz Association; German Center for Neurodegenerative Diseases
   (DZNE); Universidade de Aveiro; Maastricht University
RP Schmidt, U (corresponding author), Univ Med Ctr Gottingen UMG, Psychotrauma Treatment Unit, Gottingen, Germany.; Schmidt, U (corresponding author), Univ Med Ctr Gottingen UMG, RG Stress Modulat Neurodegenerat, Dept Psychiat & Psychotherapy, Gottingen, Germany.; Schmidt, U (corresponding author), Maastricht Univ, Med Ctr, Dept Psychiat & Neuropsychol, Sch Mental Hlth & Neurosci MHeNs, Maastricht, Netherlands.
EM ulrike.schmidt@med.uni-goettingen.de
RI Schmidt, Ulrike/KXQ-6095-2024
OI Wiltfang, Jens/0000-0003-1492-5330
FU Open Access Publication Funds of the Gottingen University
FX We acknowledge support by the Open Access Publication Funds of the
   Gottingen University.
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NR 84
TC 11
Z9 11
U1 0
U2 8
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-0640
J9 FRONT PSYCHIATRY
JI Front. Psychiatry
PD NOV 14
PY 2019
VL 10
AR 834
DI 10.3389/fpsyt.2019.00834
PG 8
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA JR2KR
UT WOS:000499461000001
PM 31798479
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Bivanco-Lima, D
   Santos, ID
   Wang, YP
   Viana, MC
   Andrade, LH
   Lotufo, PA
   Benseñor, IJM
AF Bivanco-Lima, Danielle
   Santos, Itamar de Souza
   Wang, Yuan-Pang
   Viana, Maria Carmen
   Andrade, Laura Helena
   Lotufo, Paulo Andrade
   Bensenor, Isabela Judith Martins
TI Cardiovascular risk factors and major depressive disorder: a
   cross-sectional study in Sao Paulo, Brazil
SO SAO PAULO MEDICAL JOURNAL
LA English
DT Article
DE Depression; Risk factors; Cardiovascular diseases; Depressive disorder,
   major; Depressive disorders; Cardiovascular risk; Major depressive
   disorder; Depressed individuals; Lifestyle and risk factors
ID METABOLIC SYNDROME; HEALTH-SURVEY; SYMPTOMS; DISEASE; ASSOCIATION;
   OBESITY; METAANALYSIS; INDIVIDUALS; MORTALITY; SYNDEMICS
AB BACKGROUND: Cardiovascular risk factors can mediate the association between depression and cardiovascular diseases.
   OBJECTIVE: To evaluate cardiovascular risk factors in adult individuals with and without histories of major depression in the metropolitan region of Sao Paulo, Brazil.
   DESIGN AND SETTING: Cross-sectional study in Sao Paulo (SP), Brazil.
   METHODS: This study evaluated 423 individuals without any lifetime diagnosis of major depression and 203 individuals with a previous diagnosis of major depression (n = 626). The participants underwent a psychiatric evaluation using a structured clinical interview (SCID-1), an anthropometric evaluation and a clinical evaluation that included blood pressure measurement and assessment of fasting blood glucose, lipid profile and physical activity levels.
   RESULTS: Individuals with histories of major depression were more likely to be female (P < 0.0001). Individuals with lifetime diagnoses of major depression were more likely to be current smokers (odds ratio, OR 1.61; 95% confidence interval, CI 1.01-2.59) and to have diabetes (OR 1.79; 95% CI 1.01-3.21); and less likely to be obese (OR 0.58; 95% CI 0.35-0.94).
   CONCLUSION: Individuals with major depression had higher odds of presenting tobacco smoking and diabetes, and lower odds of being obese. Healthcare professionals need to be aware of this, so as to increase the rates of diagnosis and treatment in this population.
C1 [Bivanco-Lima, Danielle; Santos, Itamar de Souza; Wang, Yuan-Pang; Viana, Maria Carmen; Andrade, Laura Helena; Lotufo, Paulo Andrade; Bensenor, Isabela Judith Martins] Univ Sao Paulo, Sect Psychiat Epidemiol LIM 23, Inst Psychiat, Fac Med FMUSP, Sao Paulo, SP, Brazil.
   [Bivanco-Lima, Danielle] Fac Ciencias Med Santa Casa Sao Paulo FCMSP, Dept Publ Hlth, Sao Paulo, SP, Brazil.
   [Santos, Itamar de Souza; Lotufo, Paulo Andrade; Bensenor, Isabela Judith Martins] Univ Sao Paulo, Hosp Univ HU, Ctr Clin & Epidemiol Res, Sao Paulo, SP, Brazil.
   [Santos, Itamar de Souza; Lotufo, Paulo Andrade; Bensenor, Isabela Judith Martins] Univ Sao Paulo, Dept Internal Med, Fac Med FMUSP, Sao Paulo, SP, Brazil.
   [Wang, Yuan-Pang; Andrade, Laura Helena] Univ Sao Paulo, Sect Psychiat Epidemiol LIM 23, Inst Psychiat, Hosp Clin FMUSP,Fac Med, Sao Paulo, SP, Brazil.
   [Viana, Maria Carmen] Univ Fed Espirito Santo UFES, Postgrad Program Collect Hlth, Vitoria, ES, Brazil.
C3 Universidade de Sao Paulo; Universidade de Sao Paulo; Universidade de
   Sao Paulo; Universidade de Sao Paulo; Universidade Federal do Espirito
   Santo
RP Bivanco-Lima, D (corresponding author), R Doutor Cesario Mota Jr 61,5 Andar,Sala 03, BR-01221020 Sao Paulo, SP, Brazil.
EM danielle.bivanco@gmail.com
RI Bensenor, Isabela/L-3306-2017; Andrade, Laura Helena/F-3023-2010; Wang,
   Yuan-Pang/A-4863-2008; Santos, Itamar/K-7055-2012; Lotufo,
   Paulo/A-9843-2008
OI Bivanco-Lima, Danielle/0000-0001-9243-0232; Andrade, Laura
   Helena/0000-0002-2362-3521; Wang, Yuan-Pang/0000-0001-7076-8312;
   Bensenor, Isabela/0000-0002-6723-5678; Santos,
   Itamar/0000-0003-3212-8466; Lotufo, Paulo/0000-0002-4856-8450
FU Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (Sao Paulo Research
   Foundation) [FAPESP 03/00204-3]; Fundo de Apoio a Ciencia e Tecnologia
   de Vitoria (FACITEC, Vitoria [Municipal] Fund for the of Science and
   Technology) [002/2003]; Conselho Nacional de Desenvolvimento Cientifico
   e Tecnologico (Brazilian National Council for Scientific and
   Technological Development) [CNPq 307933/2019-9]; United States National
   Institutes of Mental Health [R01-MH070884]; MacArthur Foundation; Pfizer
   Foundation; United States Public Health Service [R13-MH066849,
   R01-MH069864, R01-DA016558]; Fogarty International Center [FIRCA
   R03-TW006481]; Pan-American Health Organization; Eli Lilly and Company
   Foundation; Ortho-McNeil Pharmaceutical; GlaxoSmithKline; Bristol-Myers
   Squibb and Shire; Fundacao de Amparo a Pesquisa do Estado de Sao Paulo
   (FAPESP) [03/00204-3] Funding Source: FAPESP
FX The Sao Paulo Megacity Mental Health Survey was funded by the Fundacao
   de Amparo a Pesquisa do Estado de Sao Paulo (Sao Paulo Research
   Foundation; FAPESP 03/00204-3), and Fundo de Apoio a Ciencia e
   Tecnologia de Vitoria (FACITEC, Vitoria [Municipal] Fund for the Support
   of Science and Technology; 002/2003 for instrument development). The
   Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (Brazilian
   National Council for Scientific and Technological Development; CNPq
   307933/2019-9) supported Dr. L. H. Andrade. The Sao Paulo Megacity
   Mental Health Survey was conducted in conjunction with the World Health
   Organization World Mental Health Survey Initiative. The main
   coordination center activities at Harvard University were supported by
   the United States National Institutes of Mental Health (R01-MH070884),
   John D. and Catherine T. MacArthur Foundation, Pfizer Foundation and
   United States Public Health Service (R13-MH066849, R01-MH069864 and
   R01-DA016558), as well as by the Fogarty International Center (FIRCA
   R03-TW006481), Pan-American Health Organization, Eli Lilly and Company
   Foundation, Ortho-McNeil Pharmaceutical, GlaxoSmithKline, Bristol-Myers
   Squibb and Shire. A complete list of the World Mental Health
   publications can be found at http://www.hcp.med.harvard.edu/wmh/.None of
   the sponsors had any role in the design, analysis, interpretation of
   results or preparation of this paper
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NR 48
TC 2
Z9 2
U1 1
U2 4
PU ASSOCIACAO PAULISTA MEDICINA
PI SAO PAULO
PA AV BRIG LUIS ANTONIO, 278-7 ANDAR, SAO PAULO, CEP01318-901, BRAZIL
SN 1516-3180
J9 SAO PAULO MED J
JI Sao Paulo Med. J.
PD JUL-AUG
PY 2021
VL 139
IS 4
BP 364
EP 371
DI 10.1590/1516-3180.2020.0054.R1.1802021
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA TU5CJ
UT WOS:000681054100009
PM 34161521
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Yuan, Q
   Zeng, ZL
   Yang, SQ
   Li, AQ
   Zu, XY
   Liu, JH
AF Yuan, Qing
   Zeng, Z. L.
   Yang, Shiqi
   Li, Anqi
   Zu, Xuyu
   Liu, Jianghua
TI Mitochondrial Stress in Metabolic Inflammation: Modest Benefits and Full
   Losses
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Review
ID TARGETED ANTIOXIDANT MITOQ; HIGH-FAT-DIET; ADIPOSE-TISSUE; CALORIC
   RESTRICTION; OXIDATIVE STRESS; INSULIN-RESISTANCE; SKELETAL-MUSCLE;
   COMPLEX-II; OBESITY; EXERCISE
AB Energy intake and metabolic balance are the pillars of health preservation. Overnutrition causes nonspecific, persistently low inflammatory state known as metabolic inflammation. This condition contributes to the pathophysiology of various metabolic disorders, such as atherosclerosis, obesity, diabetes mellitus, and metabolic syndrome. The mitochondria maintain the balance of energy metabolism. Excessive energy stress can lead to mitochondrial dysfunction, which promotes metabolic inflammation. The inflammatory environment further impairs mitochondrial function. Accordingly, excellent organism design keeps the body metabolically healthy in the context of mitochondrial dysfunction, and moderate mitochondrial stress can have a beneficial effect. This review summarises the research progress on the multifaceted characterisation of mitochondrial dysfunction and its role in metabolic inflammation.
C1 [Yuan, Qing; Zeng, Z. L.; Yang, Shiqi; Li, Anqi; Zu, Xuyu; Liu, Jianghua] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Metab & Endocrinol, Hengyang, Peoples R China.
   [Yuan, Qing; Zeng, Z. L.; Yang, Shiqi; Li, Anqi; Liu, Jianghua] Univ South China, Hengyang, Peoples R China.
C3 University of South China; University of South China
RP Zu, XY; Liu, JH (corresponding author), Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Metab & Endocrinol, Hengyang, Peoples R China.; Liu, JH (corresponding author), Univ South China, Hengyang, Peoples R China.
EM 1398169303@qq.com; zzl@usc.edu.cn; 784770822@qq.com; 315788889@qq.com;
   476969758@qq.com; jianghua990@126.com
RI Li, Anqi/GPT-2444-2022; qing, yuan/HPI-2135-2023; ZhaoLin,
   Zeng/W-8649-2018
OI ZhaoLin, Zeng/0000-0002-9479-3982; liu, jianghua/0000-0003-3010-5113
FU National Natural Science Foundation of China; Hunan Natural Science
   Foundation; Postgraduate Scientific Research Innovation Project of Hunan
   Province;  [82270939];  [2022JJ70036];  [CX20210917]
FX AcknowledgmentsThis work is supported by the National Natural Science
   Foundation of China (No. 82270939), Hunan Natural Science Foundation
   (2022JJ70036), and the Postgraduate Scientific Research Innovation
   Project of Hunan Province (CX20210917).
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NR 163
TC 17
Z9 18
U1 4
U2 18
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PD NOV 22
PY 2022
VL 2022
AR 8803404
DI 10.1155/2022/8803404
PG 17
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA 6T0VA
UT WOS:000893400300001
PM 36457729
OA hybrid
DA 2025-06-11
ER

PT J
AU Frangou, S
   Shirali, M
   Adams, MJ
   Howard, DM
   Gibson, J
   Hall, LS
   Smith, BH
   Padmanabhan, S
   Murray, AD
   Porteous, DJ
   Haley, CS
   Deary, IJ
   Clarke, TK
   McIntosh, AM
AF Frangou, Sophia
   Shirali, Masoud
   Adams, Mark J.
   Howard, David M.
   Gibson, Jude
   Hall, Lynsey S.
   Smith, Blair H.
   Padmanabhan, Sandosh
   Murray, Alison D.
   Porteous, David J.
   Haley, Chris S.
   Deary, Ian J.
   Clarke, Toni-Kim
   McIntosh, Andrew M.
TI Insulin resistance: Genetic associations with depression and cognition
   in population based cohorts
SO EXPERIMENTAL NEUROLOGY
LA English
DT Article
DE Insulin resistance; Mendelian randomization; Polygenic risk scores;
   Genetic association; Depression; Cognition
ID METABOLIC SYNDROME; MENDELIAN RANDOMIZATION; DIABETES-MELLITUS;
   BIDIRECTIONAL ASSOCIATION; PROVISIONAL REPORT; PHYSICAL-ACTIVITY; VERBAL
   FLUENCY; LIFE-SPAN; RISK; GLUCOSE
AB Insulin resistance, broadly defined as the reduced ability of insulin to exert its biological action, has been associated with depression and cognitive dysfunction in observational studies. However, it is unclear whether these associations are causal and whether they might be underpinned by other shared factors. To address this knowledge gap, we capitalized on the stability of genetic biomarkers through the lifetime, and on their unidirectional relationship with depression and cognition. Specifically, we determined the association between quantitative measures of cognitive function and depression and genetic instruments of insulin resistance traits in two large-scale population samples, the Generation Scotland: Scottish Family Health Study (GS: SFHS; N = 19,994) and in the UK Biobank (N = 331,374). In the GS:SFHS, the polygenic risk score (PRS) for fasting insulin was associated with verbal intelligence and depression while the PRS for the homeostasis model assessment of insulin resistance was associated with verbal intelligence. Despite this overlap in genetic architecture, Mendelian randomization analyses in the GS:SFHS and in the UK Biobank samples did not yield evidence for causal associations from insulin resistance traits to either depression or cognition. These findings may be due to weak genetic instruments, limited cognitive measures and insufficient power but they may also indicate the need to identify other biological mechanisms that may mediate the relationship from insulin resistance to depression and cognition.
C1 [Frangou, Sophia] Icahn Sch Med Mt Sinai, Dept Psychiat, 1425 Madison Ave, New York, NY 10029 USA.
   [Shirali, Masoud; Adams, Mark J.; Howard, David M.; Gibson, Jude; Hall, Lynsey S.; Clarke, Toni-Kim; McIntosh, Andrew M.] Univ Edinburgh, Royal Edinburgh Hosp, Div Psychiat, Edinburgh, Midlothian, Scotland.
   [Smith, Blair H.] Univ Dundee, Ninewells Hosp & Med Sch, Div Populat Hlth Sci, Dundee, Scotland.
   [Padmanabhan, Sandosh] Univ Glasgow, Inst Cardiovasc & Med Sci, Glasgow, Lanark, Scotland.
   [Murray, Alison D.] Univ Aberdeen, Aberdeen Biomed Imaging Ctr, Aberdeen, Scotland.
   [Porteous, David J.; Deary, Ian J.; McIntosh, Andrew M.] Univ Edinburgh, Ctr Cognit Ageing & Cognit Epidemiol, Edinburgh, Midlothian, Scotland.
   [Porteous, David J.] Univ Edinburgh, Inst Genet & Mol Med, Ctr Genom & Expt Med, Generat Scotland,Med Genet Sect, Edinburgh, Midlothian, Scotland.
   [Haley, Chris S.] Univ Edinburgh, Inst Genet & Mol Med, Human Genet Unit, Med Res Council, Edinburgh, Midlothian, Scotland.
   [Deary, Ian J.; McIntosh, Andrew M.] Univ Edinburgh, Dept Psychol, Edinburgh, Midlothian, Scotland.
C3 Icahn School of Medicine at Mount Sinai; Royal Infirmary of Edinburgh;
   University of Edinburgh; University of Dundee; University of Glasgow;
   University of Aberdeen; University of Edinburgh; University of
   Edinburgh; UK Research & Innovation (UKRI); Medical Research Council UK
   (MRC); University of Edinburgh; University of Edinburgh
RP Frangou, S (corresponding author), Icahn Sch Med Mt Sinai, Dept Psychiat, 1425 Madison Ave, New York, NY 10029 USA.
EM sophia.frangou@mssm.edu
RI Frangou, Sophia/A-2672-2013; Murray, Alison/H-6250-2017; Haley,
   Chris/F-3110-2013; Deary, Ian/C-6297-2009; Porteous,
   David/MAI-3874-2025; Howard, David/I-6500-2019; Clarke,
   Toni/AAE-7069-2019; Smith, Blair/G-2834-2012; Shirali,
   Masoud/GYH-0339-2022; McIntosh, Andrew/B-9379-2008
OI Murray, Alison/0000-0003-4915-4847; Clarke,
   Toni-Kim/0000-0002-7745-6351; Padmanabhan, Sandosh/0000-0003-3869-5808;
   Howard, David/0000-0002-6005-1972; Smith, Blair/0000-0002-5362-9430;
   Shirali, Masoud/0000-0002-5401-0541; McIntosh,
   Andrew/0000-0002-0198-4588
FU Wellcome Trust [104036/Z/14/Z]; Medical Research Council; National
   Institute of Mental Health, USA [R01MH113619, R01MH116147]; consortium
   for Psychopathology and Allostatic load across the Life Span (PALS); Dr.
   Mortimer and Theresa Sackler Foundation; cross council Lifelong Health
   and Wellbeing Initiative [MR/K026992/1]; Chief Scientist Office of the
   Scottish Government Health Directorates [CZD/16/6]; Scottish Funding
   Council [HR03006]; Biotechnology and Biological Sciences Research
   Council; MRC [G0700704, MC_UU_00007/10] Funding Source: UKRI
FX We are grateful to the families who took part in GS:SFHS, general
   practitioners and the Scottish School of Primary Care for their help in
   recruitment, and the whole GS:SFHS team that includes academic
   researchers, clinic staff, laboratory technicians, clerical workers, IT
   staff, statisticians and research managers. The research reported here,
   and the genotyping of GS:SFHS samples was funded by the Wellcome Trust,
   (Wellcome Trust Strategic Award 'STratifying Resilience and Depression
   Longitudinally' (STRADL) Reference 104036/Z/14/Z) and by the Medical
   Research Council. SF acknowledges support from the National Institute of
   Mental Health, USA (R01MH113619; R01MH116147) and the consortium for
   Psychopathology and Allostatic load across the Life Span (PALS;
   https://www.pals-network.org) AMM acknowledges the financial support
   received from the Dr. Mortimer and Theresa Sackler Foundation. IJD and
   AMM are members of The University of Edinburgh Centre for Cognitive
   Ageing and Cognitive Epidemiology, part of the cross council Lifelong
   Health and Wellbeing Initiative (MR/K026992/1). Generation Scotland
   received core support from the Chief Scientist Office of the Scottish
   Government Health Directorates (CZD/16/6) and the Scottish Funding
   Council (HR03006). Funding from the Biotechnology and Biological
   Sciences Research Council and Medical Research Council is gratefully
   acknowledged.
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NR 92
TC 15
Z9 15
U1 1
U2 17
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0014-4886
EI 1090-2430
J9 EXP NEUROL
JI Exp. Neurol.
PD JUN
PY 2019
VL 316
BP 20
EP 26
DI 10.1016/j.expneurol.2019.04.001
PG 7
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology
GA HX8NV
UT WOS:000467663500003
PM 30965038
OA Green Published, Green Accepted, hybrid
DA 2025-06-11
ER

PT J
AU Kristensen, M
   Nierenberg, AA
   Ostergaard, SD
AF Kristensen, M.
   Nierenberg, A. A.
   Ostergaard, S. D.
TI Face and predictive validity of the ClockΔ19 mouse as an animal
   model for bipolar disorder: a systematic review
SO MOLECULAR PSYCHIATRY
LA English
DT Review
ID PSYCHIATRY WFSBP GUIDELINES; DEPRESSION-RELATED BEHAVIOR; METABOLIC
   SYNDROME; BIOLOGICAL TREATMENT; WORLD FEDERATION;
   SCHIZOPHRENIA-PATIENTS; CLOCK; LITHIUM; MANIA; DOPAMINE
AB Mice carrying the circadian locomotor output cycles Kaput delta 19 N-ethyl-N-nitrosoure (ENU) mutation (Clock Delta 19) are used as an animal model for bipolar disorder (BD). We aimed to systematically review the face validity (phenotypical and pathophysiological resemblance with BD) and predictive validity (responsiveness to treatments used in BD) of this model in adherence with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline. We carried out a systematic search of the databases PubMed and Embase, combining search terms covering BD and Clock Delta 19. The 22 studies included in the review (from a total of 1281 identified records) show that the behavioral phenotype of the Clock Delta 19 mouse is characterized by hyperactivity, decreased anxiety-like behavior, decreased depression-like behavior and increased preference for rewarding stimuli. This is highly consistent with mania in humans. Moreover, the Clock Delta 19 mouse exhibits rapid mood cycling (a manic-like phenotype during the day followed by euthymia at night), which is consistent with BD. Chronic administration of lithium, a drug with well established mood-stabilizing effect in humans with BD, reverses the majority of the bipolar-like traits and most of the neurobiological abnormalities observed in the Clock Delta 19 mouse. In conclusion, the Clock Delta 19 mouse has substantial face validity as an animal model for BD. The predictive validity of the Clock Delta 19 mouse has primarily been investigated via studies using lithium challenge. Therefore, further studies are needed to determine how the Clock Delta 19 mouse responds to other mood-stabilizing treatments of BD such as valproate, lamotrigine, carbamazepine, oxcarbazepine, antipsychotics, electroconvulsive therapy and various light interventions.
C1 [Kristensen, M.; Ostergaard, S. D.] Aarhus Univ Hosp, Psychosis Res Unit, Risskov, Denmark.
   [Kristensen, M.; Ostergaard, S. D.] Aarhus Univ, Dept Clin Med, Aarhus, Denmark.
   [Nierenberg, A. A.] Harvard Med Sch, Massachusetts Gen Hosp, Bipolar Clin & Res Program, Boston, MA USA.
   [Ostergaard, S. D.] Aarhus Univ, Aarhus Inst Adv Studies, Aarhus, Denmark.
C3 Aarhus University; Aarhus University; Harvard University; Harvard
   University Medical Affiliates; Massachusetts General Hospital; Harvard
   Medical School; Aarhus University
RP Ostergaard, SD (corresponding author), Aarhus Univ Hosp, Dept Clin Med, Psychosis Res Unit, Skovagervej 2, DK-8240 Risskov, Denmark.
EM soeoes@rm.dk
RI Nierenberg, ANierenberg/IAR-5549-2023
OI Ostergaard, Soren Dinesen/0000-0002-8032-6208
FU Lundbeck Foundation [R165-2013-15320]
FX We are thankful to research librarian Helene Sognstrup, Aarhus
   University Library-Psychiatry, Aarhus, Denmark. SDO is supported by a
   grant from the Lundbeck Foundation (R165-2013-15320).
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NR 85
TC 27
Z9 29
U1 0
U2 14
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 1359-4184
EI 1476-5578
J9 MOL PSYCHIATR
JI Mol. Psychiatr.
PD JAN
PY 2018
VL 23
IS 1
BP 70
EP 80
DI 10.1038/mp.2017.192
PG 11
WC Biochemistry & Molecular Biology; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Biochemistry & Molecular Biology; Neurosciences & Neurology; Psychiatry
GA FT8ZF
UT WOS:000423441000010
PM 29112195
DA 2025-06-11
ER

PT J
AU Theodosis-Nobelos, P
   Rekka, EA
AF Theodosis-Nobelos, Panagiotis
   Rekka, Eleni A.
TI The Antioxidant Potential of Vitamins and Their Implication in Metabolic
   Abnormalities
SO NUTRIENTS
LA English
DT Review
DE vitamins; oxidative stress; antioxidant activity; metabolic disorders;
   degenerative conditions
ID GLYCATION END-PRODUCTS; TRANS-RETINOIC ACID; OXIDATIVE STRESS;
   HYDROGEN-SULFIDE; HEART-FAILURE; FREE-RADICALS; D DEFICIENCY; LIPOIC
   ACID; IN-VITRO; MITOCHONDRIAL DYSFUNCTION
AB Vitamins are micronutrients necessary for the normal function of the body. Although each vitamin has different physicochemical properties and a specific role in maintaining life, they may also possess a common characteristic, i.e., antioxidant activity. Oxidative stress can harm all the main biological structures leading to protein, DNA and lipid oxidation, with concomitant impairment of the cell. It has been established that oxidative stress is implicated in several pathological conditions such as atherosclerosis, diabetes, obesity, inflammation and metabolic syndrome. In this review we investigate the influence of oxidative stress on the above conditions, examine the interrelation between oxidative stress and inflammation and point out the importance of vitamins in these processes, especially in oxidative load manipulation and metabolic abnormalities.
C1 [Theodosis-Nobelos, Panagiotis] Frederick Univ, Sch Hlth Sci, Dept Pharm, CY-1036 Nicosia, Cyprus.
   [Rekka, Eleni A.] Aristotelian Univ Thessaloniki, Sch Pharm, Dept Pharmaceut Chem, Thessaloniki 54124, Greece.
C3 Aristotle University of Thessaloniki
RP Theodosis-Nobelos, P (corresponding author), Frederick Univ, Sch Hlth Sci, Dept Pharm, CY-1036 Nicosia, Cyprus.
EM hsc.np@frederick.ac.cy; rekka@pharm.auth.gr
RI Thedosis-Nobelos, Panagiotis/MCK-4639-2025
OI Thedosis-Nompelos, Panagiotis/0000-0003-3153-6425
FX This research received no external funding.
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NR 203
TC 3
Z9 3
U1 9
U2 13
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD AUG
PY 2024
VL 16
IS 16
AR 2740
DI 10.3390/nu16162740
PG 25
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA E8O1N
UT WOS:001305529200001
PM 39203876
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Esteve, M
AF Esteve, Montserrat
TI Mechanisms Underlying Biological Effects of Cruciferous
   Glucosinolate-Derived Isothiocyanates/Indoles: A Focus on Metabolic
   Syndrome
SO FRONTIERS IN NUTRITION
LA English
DT Review
DE cruciferous; glucosinolates; isothiocyanates; indoles; metabolic
   syndrome; inflammation; Nuclear erythroid 2-related factor (Nrf2);
   Nuclear Factor-kappa B (NF-kappa B)
ID CELL-CYCLE ARREST; NF-KAPPA-B; PROSTATE-CANCER CELLS; DIFFERENT COOKING
   METHODS; GLYCATION END-PRODUCTS; SULFORAPHANE INDUCES APOPTOSIS; HISTONE
   DEACETYLASE ACTIVITY; ULTRA-PROCESSED FOODS; PHENETHYL ISOTHIOCYANATE;
   ADIPOSE-TISSUE
AB An inverse correlation between vegetable consumption and the incidence of cancer has long been described. This protective effect is stronger when cruciferous vegetables are specifically consumed. The beneficial properties of vegetables are attributed to their bioactive components like fiber, antioxidants vitamins, antioxidants, minerals, and phenolic compounds. Cruciferous vegetables contain all these molecules; however, what makes them different are their sulfurous components, called glucosinolates, responsible for their special smell and taste. Glucosinolates are inactive biologically in the organism but are hydrolyzed by the enzyme myrosinase released as a result of chewing, leading to the formation of active derivatives such as isothiocyanates and indoles. A considerable number ofin vitroandin vivostudies have reported that isothiocyanates and indoles elicit chemopreventive potency through multiple mechanisms that include modulation of phases I and II detoxification pathway enzymes, regulation of cell cycle arrest, and control of cell growth, induction of apoptosis, antioxidant activity, anti-angiogenic effects, and epigenetic regulation. Nuclear erythroid 2-related factor 2 (Nrf2) and Nuclear factor-kappa B (NF-kappa B) are key and central regulators in all these processes with a main role in oxidative stress and inflammation control. It has been described that isothiocyanates and indoles regulate their activity directly and indirectly. Today, the metabolic syndrome (central obesity, insulin resistance, hyperlipidemia, and hypertension) is responsible for a majority of deaths worldwide. All components of metabolic syndrome are characterized by chronic inflammation with deregulation of the PI3K/AKT/mTOR, MAPK/EKR/JNK, Nrf2, and NF-kappa B signaling pathways. The effects of GLSs derivatives controlling these pathways have been widely described in relation to cancer. Changes in food consumption patterns observed in the last decades to higher consumption of ultra-processed foods, with elevation in simple sugar and saturated fat contents and lower consumption of vegetables and fruits have been directly correlated with metabolic syndrome prevalence. In this review, it is summarized the knowledge regarding the mechanisms by which cruciferous glucosinolate derivatives (isothiocyanates and indoles) directly and indirectly regulate these pathways. However, the review places a special focus on the knowledge of the effects of glucosinolates derivatives in metabolic syndrome, since this has not been reviewed before.
C1 [Esteve, Montserrat] Univ Barcelona, Dept Biochem & Mol Biomed, Barcelona, Spain.
   [Esteve, Montserrat] Inst Hlth Carlos III, Biomed Res Ctr Physiopathol Obes & Nutr CIBERobn, Madrid, Spain.
C3 University of Barcelona; CIBER - Centro de Investigacion Biomedica en
   Red; CIBEROBN
RP Esteve, M (corresponding author), Univ Barcelona, Dept Biochem & Mol Biomed, Barcelona, Spain.; Esteve, M (corresponding author), Inst Hlth Carlos III, Biomed Res Ctr Physiopathol Obes & Nutr CIBERobn, Madrid, Spain.
EM mesteve@ub.edu
RI Esteve, Montserrat/L-6272-2014
OI Esteve, Montserrat/0000-0003-2128-7859
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NR 282
TC 84
Z9 87
U1 1
U2 34
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD SEP 2
PY 2020
VL 7
AR 111
DI 10.3389/fnut.2020.00111
PG 22
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA NS8GH
UT WOS:000572493800001
PM 32984393
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Song, CF
   Tay, PKC
   Gwee, X
   Wee, SL
   Ng, TP
AF Song, Cai Feng
   Tay, Peter Kay Chai
   Gwee, Xinyi
   Wee, Shiou Liang
   Ng, Tze Pin
TI Happy people live longer because they are healthy people
SO BMC GERIATRICS
LA English
DT Article
DE Happiness; Mortality; Positive affect; Longevity; Well-being
ID MILD COGNITIVE IMPAIRMENT; METABOLIC SYNDROME; FOLLOW-UP; ALL-CAUSE;
   MORTALITY; HAPPINESS; LIFE
AB ObjectivesHigher levels of happiness are associated with longer life expectancy. Our study assessed the extent to which various factors explain the protective effect of happiness on all-cause mortality risk, and whether the association differs between older men and women.MethodsUsing data from the Singapore Longitudinal Aging Studies (N = 6073) of community-dwelling older adults aged & GE; 55 years, we analyzed the association of baseline Likert score of happiness (1 = very sad to 5 = very happy) and mortality from mean 11.7 years of follow up. Cox regression models were used to assess the extent to which confounding risk factors attenuated the hazard ratio of association in the whole sample and sex-stratified analyses.ResultsHappiness was significantly associated with lower mortality (p < .001) adjusted for age, sex and ethnicity: HR = 0.85 per integer score and HR = 0.57 for fairly-or-very happy versus fairly-or-very sad. The HR estimate (0.90 per integer score) was modestly attenuated (33.3%) in models that included socio-demographic and support, lifestyle or physical health and functioning factor, but remained statistically significant. The HR estimate (0.94 per integer score) was substantially attenuated (60%) and was insignificant in the model that included psychological health and functioning. Including all co-varying factors in the model resulted in statistically insignificant HR estimate (1.04 per integer score). Similar results were obtained for HR estimates for fairly-to-very happy versus fairly-to- very sad).DiscussionMuch of the association between happiness and increased life expectancy could be explained by socio-demographic, lifestyle, health and functioning factors, and especially psychological health and functioning factors.
C1 [Song, Cai Feng; Tay, Peter Kay Chai; Wee, Shiou Liang] Singapore Inst Technol, Hlth & Social Sci, 10 Dover Dr, Singapore 138683, Singapore.
   [Gwee, Xinyi; Ng, Tze Pin] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Psychol Med, Singapore, Singapore.
C3 Singapore Institute of Technology; National University of Singapore
RP Wee, SL (corresponding author), Singapore Inst Technol, Hlth & Social Sci, 10 Dover Dr, Singapore 138683, Singapore.
EM weeshioulang@gmail.com
RI Wee, Shiou-Liang/H-7115-2019
OI Wee, Shiou-Liang/0000-0002-7853-4112
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NR 45
TC 7
Z9 7
U1 3
U2 7
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2318
J9 BMC GERIATR
JI BMC Geriatr.
PD JUL 18
PY 2023
VL 23
IS 1
AR 440
DI 10.1186/s12877-023-04030-w
PG 10
WC Geriatrics & Gerontology; Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA M6MN9
UT WOS:001031338700002
PM 37464330
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Kim, YH
   Ryu, S
   Nam, HJ
   Kim, M
   Jhon, M
   Lee, JY
   Kim, JM
   Shin, MH
   Chung, YC
   Kim, SW
AF Kim, Young-Hyuk
   Ryu, Seunghyong
   Nam, Hee-Jung
   Kim, Mina
   Jhon, Min
   Lee, Ju-Yeon
   Kim, Jae-Min
   Shin, Min Ho
   Chung, Young-Chul
   Kim, Sung-Wan
TI The Psychology of Food Cravings in Patients With First-Episode Psychosis
SO FRONTIERS IN PSYCHIATRY
LA English
DT Article
DE weight gain; food craving; schizophrenia; First-Episode Psychosis (FEP);
   stress; depression
ID BODY-MASS INDEX; QUALITY-OF-LIFE; WEIGHT-GAIN; METABOLIC SYNDROME;
   CHRONIC STRESS; NAIVE SCHIZOPHRENIA; GENDER DIFFERENCES; PERCEIVED
   STRESS; PHYSICAL HEALTH; SOCIAL SUPPORT
AB Objectives: Food cravings may cause weight gain in patients with schizophrenia. This study investigated psychological characteristics associated with food cravings in patients with first-episode psychosis.
   Methods: This study analyzed data from a clinical cohort of first-episode psychosis patients taking antipsychotics for 3 months or less. The strength of food cravings was measured using the General Food Cravings Questionnaire-Trait (G-FCQ-T). Psychological characteristics and psychiatric symptoms were investigated with the Positive and Negative Symptom Scale (PANSS), Calgary Depression Scale for Schizophrenia (CDSS), Social and Occupational Functioning Assessment Scale, Rosenberg Self-Esteem Scale (RSES), and Perceived Stress Scale (PSS). Clinical characteristics were compared according to significant weight gain (>= 10% increase in body weight compared to baseline) over 3 months. Associations between the G-FCQ-T and other psychiatric scales were investigated. We conducted sex-stratified analyses.
   Results: In total, 182 patients (78 males and 104 females) with first-episode psychosis were enrolled in this study. In females, the G-FCQ-T total score at baseline was associated with baseline body weight and significant weight gain over 3 months. The PSS scales were significantly associated the G-FCQ-T total and all subscale scores in female participants. Scores on the RSES and CDSS were significantly associated with the G-FCQ-T total score and with the preoccupation and loss of control subscale scores. The PANSS negative and general subscales were significantly associated with the positive outcome expectancy and loss of control subscales of the G-FCQ-T, respectively. In males, the only significant association was between the loss of control subscale and RSES scores. Linear regression analysis showed significant associations of PSS scores with the total and all subscale scores of the G-FCQ-T despite the loss of significance for other variables.
   Conclusion: These results indicate that the food cravings in patients with first-episode psychosis, which were associated with weight gain, were influenced by perceived stress in females. To reduce food cravings in female patients with schizophrenia, interventions aimed at perceived stress should be considered.
C1 [Kim, Young-Hyuk; Ryu, Seunghyong; Jhon, Min; Lee, Ju-Yeon; Kim, Jae-Min; Kim, Sung-Wan] Chonnam Natl Univ, Dept Psychiat, Med Sch, Gwangju, South Korea.
   [Nam, Hee-Jung] Seoul Med Ctr, Dept Psychiat, Seoul, South Korea.
   [Kim, Mina; Lee, Ju-Yeon; Kim, Sung-Wan] Gwangju Mental Hlth & Welf Commiss, Gwangju, South Korea.
   [Kim, Mina] Chonnam Natl Univ, Grad Sch, Dept Nursing, Gwangju, South Korea.
   [Shin, Min Ho] Chonnam Natl Univ, Dept Prevent Med, Med Sch, Hwasun, South Korea.
   [Chung, Young-Chul] Chonbuk Natl Univ, Dept Psychiat, Med Sch, Jeonju, South Korea.
C3 Chonnam National University; Seoul Medical Center; Chonnam National
   University; Chonnam National University; Jeonbuk National University
RP Kim, SW (corresponding author), Chonnam Natl Univ, Dept Psychiat, Med Sch, Gwangju, South Korea.; Kim, SW (corresponding author), Gwangju Mental Hlth & Welf Commiss, Gwangju, South Korea.
EM swkim@chonnam.ac.kr
RI Chung, Young/AAB-8242-2022; Lee, Jung-Seok/L-6826-2019
FU Korean Mental Health Technology R&D Project, Ministry of Health &
   Welfare, Republic of Korea [HL19C0015]; Basic Science Research Program
   through the National Research Foundation of Korea [NRF-2017R1A2B4010830]
FX YY This study was supported by a grant of the Korean Mental Health
   Technology R&D Project, Ministry of Health & Welfare, Republic of Korea
   (HL19C0015) and a grant from the Basic Science Research Program through
   the National Research Foundation of Korea (NRF-2017R1A2B4010830). The
   funder had no role in study design; in the writing of the report; or in
   the decision to submit the paper for publication.
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NR 81
TC 4
Z9 4
U1 0
U2 8
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-0640
J9 FRONT PSYCHIATRY
JI Front. Psychiatry
PD DEC 11
PY 2020
VL 11
AR 587486
DI 10.3389/fpsyt.2020.587486
PG 9
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA PJ2HM
UT WOS:000601595800001
PM 33362604
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Kapoor, A
   Sanyal, AJ
AF Kapoor, Ashwani
   Sanyal, Arun J.
TI Endoplasmic Reticulum Stress and the Unfolded Protein Response
SO CLINICS IN LIVER DISEASE
LA English
DT Article
DE Non-alcoholic fatty liver disease; Non-alcoholic steatohepatitis; Fatty
   liver; Unfolded protein response; ER stress; Eukaryotic initiation
   factor; Inflammation; Metabolic syndrome
ID FATTY LIVER-DISEASE; ER STRESS; TRANSCRIPTION FACTOR; MESSENGER-RNA;
   NONALCOHOLIC STEATOHEPATITIS; HEPATOCYTE APOPTOSIS; SIGNAL-TRANSDUCTION;
   CELL-SURVIVAL; DEGRADATION; ACTIVATION
AB The endoplasmic reticulum (ER) is the key cellular organelle involved in protein homoeostasis. The unfolded protein response (UPR) is a fundamental cellular process triggered by ER stress because of lack of ATP or primary ER dysfunction. The UPR is activated and dysregulated in non-alcoholic fatty liver disease (NAFLD). The UPR has been shown to be involved in both normal physiologic functions and the cellular response to a host of pathologic states. This article reviews the pathways by which the UPR unfolds and its potential role in the development and progression of NAFLD.
C1 [Kapoor, Ashwani; Sanyal, Arun J.] Virginia Commonwealth Univ, Sch Med, Div Gastroenterol Hepatol & Nutr, Dept Internal Med, Richmond, VA 23298 USA.
C3 Virginia Commonwealth University
RP Sanyal, AJ (corresponding author), Virginia Commonwealth Univ, Sch Med, Div Gastroenterol Hepatol & Nutr, Dept Internal Med, 1200 E Broad St,MCV Box 980341, Richmond, VA 23298 USA.
EM asanyal@mcvh-vcu.edu
FU National Institutes of Health [K24 DK 02755-09]
FX It was supported in part by a grant from the National Institutes of
   Health to Dr. Arun Sanyal, K24 DK 02755-09.
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NR 58
TC 85
Z9 98
U1 1
U2 17
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 1089-3261
EI 1557-8224
J9 CLIN LIVER DIS
JI Clin. Liver Dis.
PD NOV
PY 2009
VL 13
IS 4
BP 581
EP +
DI 10.1016/j.cld.2009.07.004
PG 11
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 514JJ
UT WOS:000271390100006
PM 19818306
DA 2025-06-11
ER

PT S
AU Stadler, K
AF Stadler, Krisztian
BE Ahmad, SI
TI OXIDATIVE STRESS IN DIABETES
SO DIABETES: AN OLD DISEASE, A NEW INSIGHT
SE Advances in Experimental Medicine and Biology
LA English
DT Article; Book Chapter
ID POLY(ADP-RIBOSE) POLYMERASE ACTIVATION; PROTEIN-KINASE-C; INDUCED
   INSULIN-RESISTANCE; ALDOSE REDUCTASE INHIBITION; NITRIC-OXIDE SYNTHASE;
   PEROXYNITRITE DECOMPOSITION CATALYST; ENZYME GENE-EXPRESSION;
   FREE-RADICAL FORMATION; MITOCHONDRIAL DYSFUNCTION; NITROSATIVE STRESS
AB Oxidative stress and diabetes, both Type I and Type 2 as well as their related conditions have been extensively studied. As diabetes, obesity and metabolic syndrome have reached at epidemic levels, there is a huge need and effort to understand the detailed molecular mechanisms of the possible redo x imbalance, underlying the cause of pathology and progression of the disease. These studies provide new insights at cellular and subcellular levels to design effective clinical interventions. This chapter is intended to emphasize the latest knowledge and current evidence on the role of oxidative stress in diabetes as well as to discuss some key questions that are currently under discussion
C1 Pennington Biomed Res Ctr, Baton Rouge, LA 70808 USA.
C3 Louisiana State University System; Louisiana State University;
   Pennington Biomedical Research Center
RP Stadler, K (corresponding author), Pennington Biomed Res Ctr, 6400 Perkins Rd, Baton Rouge, LA 70808 USA.
EM krisztian.stadler@pbrc.edu
RI Stadler, Krisztian/N-1992-2017
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NR 124
TC 81
Z9 87
U1 0
U2 4
PU SPRINGER
PI NEW YORK
PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES
SN 0065-2598
EI 2214-8019
BN 978-1-4614-5441-0; 978-1-4614-5440-3
J9 ADV EXP MED BIOL
JI Adv.Exp.Med.Biol.
PY 2013
VL 771
BP 272
EP 287
D2 10.1007/978-1-4614-5441-0
PG 16
WC Endocrinology & Metabolism; Medicine, Research & Experimental
WE Book Citation Index – Science (BKCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Research & Experimental Medicine
GA BA2XL
UT WOS:000333979500022
PM 23393685
DA 2025-06-11
ER

PT J
AU Salo, KI
   Scharfen, J
   Wilden, ID
   Schubotz, RI
   Holling, H
AF Salo, Katharina, I
   Scharfen, Jana
   Wilden, Isabelle D.
   Schubotz, Ricarda, I
   Holling, Heinz
TI Confining the Concept of Vascular Depression to Late-Onset Depression: A
   Meta-Analysis of MRI-Defined Hyperintensity Burden in Major Depressive
   Disorder and Bipolar Disorder
SO FRONTIERS IN PSYCHOLOGY
LA English
DT Review
DE white matter hyperintensities (WMH); leukoaraiosis; major depressive
   disorder; bipolar disorder; depression; cerebrovascular pathology;
   hyperintense lesions
ID WHITE-MATTER HYPERINTENSITIES; LATE-LIFE DEPRESSION; ORBITOFRONTAL
   CORTEX VOLUME; CARDIOVASCULAR RISK-FACTORS; MILD COGNITIVE IMPAIRMENT;
   SIGNAL HYPERINTENSITIES; HOMOCYSTEINE LEVELS; METABOLIC SYNDROME;
   ELDERLY SUBJECTS; OLDER-ADULTS
AB Background: The vascular depression hypothesis emphasizes the significance of vascular lesions in late-life depression. At present, no meta-analytic model has investigated whether a difference in hyperintensity burden compared to controls between late-life and late-onset depression is evident. By including a substantial number of studies, focusing on a meaningful outcome measure, and considering several moderating and control variables, the present meta-analysis investigates the severity of hyperintensity burden in major depressive disorder (MDD) and bipolar disorder (BD). A major focus of the present meta-analysis refers to the role of age at illness onset. It is analyzed whether late-onset rather than late-life depression characterizes vascular depression.
   Method: In total, 68 studies were included in the meta-analysis and a multilevel random effects model was calculated using Hedges' g as the effect size measure.
   Results: The severity of hyperintensity burden was significantly greater in the patient group compared to the control group. This effect was evident regarding the whole patient group (g = 0.229) as well as both depression subgroups, with a significantly greater effect in BD (g = 0.374) compared to MDD (g = 0.189). Hyperintensity burden was more pronounced in late-onset depression than in early-onset depression or late-life depression. A considerable heterogeneity between the included studies was observed, which is reflected by the large variability in effects sizes.
   Conclusion: In conclusion, the present meta-analysis underscores the association of hyperintensities with MDD and BD. Especially late-onset depression is associated with an increased hyperintensity burden, which is in line with the vascular depression hypothesis. The results suggest that it might be more feasible to confine the concept of vascular depression specifically to late-onset depression as opposed to late-life depression. Further research is needed to understand the causal mechanisms that might underlie the relation between hyperintensity burden and depression.
C1 [Salo, Katharina, I; Scharfen, Jana; Wilden, Isabelle D.; Schubotz, Ricarda, I; Holling, Heinz] Westfalische Wilhelms Univ, Inst Psychol, Dept Psychol & Sports Sci, Munster, Germany.
C3 University of Munster
RP Salo, KI (corresponding author), Westfalische Wilhelms Univ, Inst Psychol, Dept Psychol & Sports Sci, Munster, Germany.
EM katharina.salo@gmail.com
RI Schubotz, Ricarda/B-2871-2013; Holling, Heinz/K-3728-2017
OI Schubotz, Ricarda/0000-0001-5802-6869; Holling,
   Heinz/0000-0002-0311-3970; Salo, Katharina Ida/0000-0002-8311-3195
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NR 189
TC 32
Z9 36
U1 0
U2 5
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-1078
J9 FRONT PSYCHOL
JI Front. Psychol.
PD MAY 31
PY 2019
VL 10
AR 1241
DI 10.3389/fpsyg.2019.01241
PG 21
WC Psychology, Multidisciplinary
WE Social Science Citation Index (SSCI)
SC Psychology
GA IB4VX
UT WOS:000470271300001
PM 31214072
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Woodward, ML
   Gicas, KM
   Warburton, DE
   White, RF
   Rauscher, A
   Leonova, O
   Su, W
   Smith, GN
   Thornton, AE
   Vertinsky, AT
   Phillips, AA
   Goghari, VM
   Honer, WG
   Lang, DJ
AF Woodward, M. L.
   Gicas, K. M.
   Warburton, D. E.
   White, R. F.
   Rauscher, A.
   Leonova, O.
   Su, W.
   Smith, G. N.
   Thornton, A. E.
   Vertinsky, A. T.
   Phillips, A. A.
   Goghari, V. M.
   Honer, W. G.
   Lang, D. J.
TI Hippocampal volume and vasculature before and after exercise in
   treatment-resistant schizophrenia
SO SCHIZOPHRENIA RESEARCH
LA English
DT Article
DE Schizophrenia; Hippocampal plasticity; MRI; SWI; Exercise; Symptoms
ID MAJOR DEPRESSIVE DISORDER; SEVERE MENTAL-ILLNESS; PHYSICAL-ACTIVITY;
   AEROBIC EXERCISE; BIPOLAR DISORDER; ANTIPSYCHOTIC-NAIVE; ADULT
   NEUROGENESIS; METABOLIC SYNDROME; PEOPLE; METAANALYSIS
AB Background: Schizophrenia is associated with poor cognitive function and elevated cardiometabolic disease risk. These health concerns may exacerbate neurocognitive dysfunction associated with hippocampal abnormalities, particularly hippocampal volume reductions. Regular exercise is thought to improve symptom severity, reduce depression, and improve cognition in schizophrenia, and may trigger exercise-mediated hippocampal growth. The potential for the benefits of exercise for treatment-resistant schizophrenia patients has not been clearly assessed. This study aims to assess the effect of exercise on hippocampal plasticity and dinical outcomes in chronic schizophrenia.
   Methods: Seventeen DSM-IV criteria schizophrenia or schizoaffective disorder patients completed a customized moderate intensity 12-week aerobic or weight-bearing exercise program. Adherence rates were 83% +/- 9.4%) with 70% of participants completing the entire exercise program. Concomitant neuroimaging, clinical and cognitive assessments were obtained at baseline and 12-weeks.
   Results: At follow-up, symptom severity scores (t(16) = -16.8, p. <= 0.0001) and social functioning (t(16) = 4.4, p. = 0.0004) improved. A trend for improved depression scores (t(16) = -2.0, p. = 0.06) with no change in anxiety, or extrapyramidal symptoms were seen. Hippocampal volume increased (t(16) = -2.54, p. = 0.02), specifically in the left CA-1 field (F(16) = -2.33, p. = 0.03). Hippocampal vascular volume was unchanged. Change in hippocampal volume and vascular volume was not significantly correlated with change in symptom severity or affect scores.
   Conclusions: Adjunct exercise may accelerate symptom improvement in treatment-resistant psychosis patients. While the underlying mechanism remains unclear, these results indicate that chronic schizophrenia patients experience hippocampal plasticity in response to exercise. (C) 2018 Elsevier B.V. All rights reserved.
C1 [Woodward, M. L.; Vertinsky, A. T.; Lang, D. J.] Univ British Columbia, Dept Radiol, Vancouver, BC, Canada.
   [Gicas, K. M.] Simon Fraser Univ, Dept Psychol, Burnaby, BC, Canada.
   [Warburton, D. E.; Phillips, A. A.] Univ British Columbia, Sch Kinesiol, Vancouver, BC, Canada.
   [Warburton, D. E.] Univ British Columbia, Expt Med Program, Vancouver, BC, Canada.
   [White, R. F.; Leonova, O.; Su, W.; Smith, G. N.; Honer, W. G.] Univ British Columbia, Dept Psychiat, Vancouver, BC, Canada.
   [Rauscher, A.; Thornton, A. E.] Univ British Columbia, Dept Pediat, Vancouver, BC, Canada.
   [Goghari, V. M.] Univ Toronto, Dept Psychol, Toronto, ON, Canada.
   [Goghari, V. M.] Univ Toronto, Grad Dept Psychol Clin Sci, Toronto, ON, Canada.
C3 University of British Columbia; Simon Fraser University; University of
   British Columbia; University of British Columbia; University of British
   Columbia; University of British Columbia; University of Toronto;
   University of Toronto
RP Lang, DJ (corresponding author), BC Childrens Hosp, British Columbia Mental Hlth & Addict Res Inst, British Columbia Childrens Hosp Res Inst, Ctr Complex Disorders, Rm 3A-124 398 West 28th Ave, Vancouver, BC V5Z 4H4, Canada.
EM dlang@mail.ubc.ca
RI Rauscher, Alexander/AFV-6957-2022; Lang, Donna/GVR-9040-2022; Woodward,
   Melissa/ABG-3627-2020; Warburton, Darren/A-2668-2019
OI Warburton, Darren/0000-0002-2842-9170; Lang, Donna/0000-0001-9373-1555;
   Woodward, Melissa/0000-0003-2697-5343
FU Canadian Institutes for Health Research, BC Mental Health Authority
   Research Services
FX The Canadian Institutes for Health Research, BC Mental Health Authority
   Research Services provided all operating funds for this study. No funds
   were apportioned for other uses and no personal benefits were provided
   to Dr. Lang or her colleagues.
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NR 66
TC 36
Z9 42
U1 2
U2 21
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0920-9964
EI 1573-2509
J9 SCHIZOPHR RES
JI Schizophr. Res.
PD DEC
PY 2018
VL 202
BP 158
EP 165
DI 10.1016/j.schres.2018.06.054
PG 8
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA HD1UW
UT WOS:000452298400024
PM 30539767
DA 2025-06-11
ER

PT J
AU Faith, MS
   Calamaro, CJ
   Dolan, MS
   Pietrobelli, A
AF Faith, MS
   Calamaro, CJ
   Dolan, MS
   Pietrobelli, A
TI Mood disorders and obesity
SO CURRENT OPINION IN PSYCHIATRY
LA English
DT Article
DE obesity; mood disorders; depression; moderator; mediator; comorbidity
ID METABOLIC SYNDROME; BODY-FAT; DEPRESSION; RISK; ASSOCIATION
AB Purpose of review
   The aim of this article is to provide an updated review of studies examining the relationship between mood disorders and obesity that have been published within the past year. The increasing number of studies using novel designs to address this topic necessitates an updated review.
   Recent findings
   The literature on mood disorders and obesity is gradually moving beyond cross-sectional designs that compare 'obese' and 'non-obese' individuals with respect to psychological functioning. An increasing number of studies have used prospective designs, tested physiological pathways linking disorders, explored changes in weight status and psychological functioning in response to treatment, and used genetic designs to examine co-morbidities.
   Summary
   Novel designs, most notably prospective studies, are advancing the understanding of the relationships between obesity and mood disorders. The use of a 'moderator-mediator' framework may facilitate the conceptualization of questions and the design of new studies.
C1 Univ Penn, Sch Med, Weight & Eating Disorders Program, Philadelphia, PA 19104 USA.
   Univ Verona, Sch Med, I-37100 Verona, Italy.
   Columbia Univ, St Lukes Roosevelt Hosp, NY Obes Res Ctr, New York, NY 10027 USA.
C3 University of Pennsylvania; University of Verona; Mount Sinai West;
   Mount Sinai St. Luke's; Columbia University
RP Univ Penn, Sch Med, Weight & Eating Disorders Program, Philadelphia, PA 19104 USA.
EM mfaith@mail.med.upenn.edu
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NR 23
TC 23
Z9 31
U1 0
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0951-7367
EI 1473-6578
J9 CURR OPIN PSYCHIATR
JI Curr. Opin. Psychiatr.
PD JAN
PY 2004
VL 17
IS 1
BP 9
EP 13
DI 10.1097/00001504-200401000-00003
PG 5
WC Psychiatry
WE Social Science Citation Index (SSCI)
SC Psychiatry
GA 774MH
UT WOS:000188982900003
DA 2025-06-11
ER

PT J
AU Wang, MX
   Li, Z
   Li, CT
   Liu, YM
   Jiang, HK
   Jia, LH
   Zhai, LL
   Sun, Q
   Wei, W
   Bai, YL
AF Wang, Mingxia
   Li, Zhao
   Li, Chuntao
   Liu, Yamin
   Jiang, Hongkun
   Jia, Lihong
   Zhai, Lingling
   Sun, Qi
   Wei, Wei
   Bai, Yinglong
TI Endoplasmic reticulum stress in adipose tissue at the intersection of
   childhood obesity-associated type 2 diabetes/insulin resistance and
   atherosclerosis
SO INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
LA English
DT Review
DE Adipose tissue; atherosclerosis; childhood obesity; diabetes mellitus;
   endoplasmic reticulum stress
ID UNFOLDED PROTEIN RESPONSE; CARDIOVASCULAR RISK-FACTORS; ER STRESS;
   INSULIN-RESISTANCE; CARDIOMETABOLIC RISK; INFLAMMATORY CHANGES;
   UNITED-STATES; FATTY-ACIDS; CHILDREN; YOUNG
AB Childhood obesity contributing to the development of metabolic diseases is a serious public health challenge on a global scale. Abnormal or excessive fat accumulation is obvious in children who are overweight or obese. As a complicated endocrine organ, adipose tissue is a predominant site of endoplasmic reticulum stress (ERS) that is induced by obesity. ERS is aggravated in obese adipose tissues, which are recognized as a molecular link between obesity and the development of metabolic diseases, such as type 2 diabetes/insulin resistance (T2D/IR) and atherosclerosis. Moreover, T2D increases the risk of atherosclerotic cardiovascular diseases (CVDs). In this review, the role of ERS in adipose tissues is analyzed, particularly regarding the initiation and exacerbation of T2D/IR and atherosclerosis. These findings indicate that it is necessary to devote more resources to the development of promising therapeutics and effective drugs to relieve ERS for the treatment of T2D and atherosclerosis, especially in children who are overweight or obese.
C1 [Wang, Mingxia; Jia, Lihong; Zhai, Lingling; Sun, Qi; Wei, Wei; Bai, Yinglong] China Med Univ, Sch Publ Hlth, Dept Child & Adolescent Hlth, Shenyang, Liaoning, Peoples R China.
   [Li, Chuntao] China Med Univ, Hosp 1, Informat Ctr, Shenyang, Liaoning, Peoples R China.
   [Li, Zhao] China Med Univ, Hosp 1, Dept Cardiol, Shenyang, Liaoning, Peoples R China.
   [Jiang, Hongkun] China Med Univ, Hosp 1, Dept Pediat, Shenyang, Liaoning, Peoples R China.
   [Liu, Yamin] Univ Calif San Francisco, Dept Cardiol, San Francisco, CA 94143 USA.
C3 China Medical University; China Medical University; China Medical
   University; China Medical University; University of California System;
   University of California San Francisco
RP Bai, YL (corresponding author), China Med Univ, Sch Publ Hlth, Dept Child & Adolescent Hlth, Shenyang North New Area, 77 Puhe Rd, Shenyang 110122, Liaoning, Peoples R China.
EM ylbai@cmu.edu.cn
RI Liu, Yamin/E-3353-2019; 白, 英龙/AAF-6124-2020
FU National Natural Science Foundation Committee of China [81373018,
   81172691]
FX The work was supported by the National Natural Science Foundation
   Committee of China (No. 81373018 and 81172691).
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NR 95
TC 1
Z9 1
U1 0
U2 7
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 1940-5901
J9 INT J CLIN EXP MED
JI Int. J. Clin. Exp. Med.
PY 2019
VL 12
IS 4
BP 3095
EP 3106
PG 12
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA HW2DW
UT WOS:000466494200007
DA 2025-06-11
ER

PT J
AU Schraplau, A
   Block, A
   Häusler, A
   Wippert, PM
   Rapp, MA
   Völler, H
   Bonaventura, K
   Mayer, F
AF Schraplau, Anne
   Block, Andrea
   Haeusler, Andreas
   Wippert, Pia-Maria
   Rapp, Michael A.
   Voeller, Heinz
   Bonaventura, Klaus
   Mayer, Frank
TI Mobile diagnostics and consultation for the prevention of the metabolic
   syndrome and its secondary diseases in Brandenburg-study protocol of a
   regional prospective cohort study: the Mobile Brandenburg Cohort
SO PILOT AND FEASIBILITY STUDIES
LA English
DT Article
DE Metabolic syndrome; Mobile diagnostics; Prevention; Nutrition; Physical
   activity; Rural health
ID PHYSICAL-ACTIVITY; WOMEN; CARE; PREVALENCE; VALIDATION; DEPRESSION;
   MORTALITY; SEVERITY; HEALTH; TRENDS
AB Background: The metabolic syndrome (MetS) is a risk cluster for a number of secondary diseases. The implementation of prevention programs requires early detection of individuals at risk. However, access to health care providers is limited in structurally weak regions. Brandenburg, a rural federal state in Germany, has an especially high MetS prevalence and disease burden. This study aims to validate and test the feasibility of a setup for mobile diagnostics of MetS and its secondary diseases, to evaluate the MetS prevalence and its association with moderating factors in Brandenburg and to identify new ways of early prevention, while establishing a "Mobile Brandenburg Cohort" to reveal new causes and risk factors for MetS.
   Methods: In a pilot study, setups for mobile diagnostics of MetS and secondary diseases will be developed and validated. A van will be equipped as an examination room using point-of-care blood analyzers and by mobilizing standard methods. In study part A, these mobile diagnostic units will be placed at different locations in Brandenburg to locally recruit 5000 participants aged 40-70 years. They will be examined for MetS and advice on nutrition and physical activity will be provided. Questionnaires will be used to evaluate sociodemographics, stress perception, and physical activity. In study part B, participants with MetS, but without known secondary diseases, will receive a detailed mobile medical examination, including MetS diagnostics, medical history, clinical examinations, and instrumental diagnostics for internal, cardiovascular, musculoskeletal, and cognitive disorders. Participants will receive advice on nutrition and an exercise program will be demonstrated on site. People unable to participate in these mobile examinations will be interviewed by telephone. If necessary, participants will be referred to general practitioners for further diagnosis.
   Discussion: The mobile diagnostics approach enables early detection of individuals at risk, and their targeted referral to local health care providers. Evaluation of the MetS prevalence, its relation to risk-increasing factors, and the "Mobile Brandenburg Cohort" create a unique database for further longitudinal studies on the implementation of home-based prevention programs to reduce mortality, especially in rural regions.
C1 [Schraplau, Anne; Mayer, Frank] Univ Potsdam, Univ Outpatient Clin Sports Med & Sports Orthoped, Neuen Palais 10, D-14469 Potsdam, Germany.
   [Schraplau, Anne; Wippert, Pia-Maria; Rapp, Michael A.; Voeller, Heinz; Mayer, Frank] Univ Potsdam, Fac Hlth Sci Brandenburg, Potsdam, Germany.
   [Block, Andrea; Wippert, Pia-Maria] Univ Potsdam, Med Sociol & Psychobiol, Potsdam, Germany.
   [Haeusler, Andreas; Rapp, Michael A.] Univ Potsdam, Social & Prevent Med, Potsdam, Germany.
   [Voeller, Heinz] Univ Potsdam, Rehabil Med, Potsdam, Germany.
   [Voeller, Heinz] Rehabil Ctr Internal Med, Klin See, Rudersdorf, Germany.
   [Bonaventura, Klaus] Ernst von Bergmann Clin, Internal Med Cardiol, Potsdam, Germany.
C3 University of Potsdam; University of Potsdam; University of Potsdam;
   University of Potsdam; University of Potsdam; Klinikum Ernst von
   Bergmann
RP Schraplau, A (corresponding author), Univ Potsdam, Univ Outpatient Clin Sports Med & Sports Orthoped, Neuen Palais 10, D-14469 Potsdam, Germany.; Schraplau, A (corresponding author), Univ Potsdam, Fac Hlth Sci Brandenburg, Potsdam, Germany.
EM anne.schraplau@uni-potsdam.de
RI Rapp, Michael/ABB-7573-2020; Wippert, Pia-Maria/AAJ-6989-2020
OI Rapp, Michael/0000-0003-0106-966X; Block, Andrea/0000-0002-4819-2529;
   Wippert, Pia-Maria/0000-0001-7221-4073
FU Ministry of Science, Research and Culture (MWFK) of the Federal State of
   Brandenburg (Germany) [85000956]; Projekt DEAL; European Union (European
   Regional Development Fund, ERDF) within the program "Starkung der
   technologischen und anwendungsnahen Forschung an
   Wissenschaftseinrichtungen (StaF-RL)" [85000956]
FX The study is funded by the Ministry of Science, Research and Culture
   (MWFK) of the Federal State of Brandenburg (Germany) with resources from
   the European Union (European Regional Development Fund, ERDF) within the
   program "Starkung der technologischen und anwendungsnahen Forschung an
   Wissenschaftseinrichtungen (StaF-RL)" [Reference: 85000956, Grant
   authority: Investitionsbank des Landes Brandenburg (ILB)]. The funders
   played no role in the design of the study. Open Access funding enabled
   and organized by Projekt DEAL.
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NR 63
TC 0
Z9 0
U1 0
U2 1
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 2055-5784
J9 PILOT FEASIBILITY ST
JI Pilot Feasibility Stud.
PD AUG 30
PY 2021
VL 7
IS 1
AR 166
DI 10.1186/s40814-021-00898-w
PG 11
WC Medicine, Research & Experimental
WE Emerging Sources Citation Index (ESCI)
SC Research & Experimental Medicine
GA UL6CD
UT WOS:000692736200001
PM 34462012
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Korycka-Bloch, R
   Balicki, P
   Guligowska, A
   Soltysik, BK
   Kostka, T
   Chrzastek, Z
AF Korycka-Bloch, Renata
   Balicki, Pawel
   Guligowska, Agnieszka
   Soltysik, Bartlomiej K.
   Kostka, Tomasz
   Chrzastek, Zuzanna
TI Weight-Adjusted Waist Index (WWI)-A Promising Anthropometric Indicator
   of Depressive Symptoms in Hospitalized Older Patients
SO NUTRIENTS
LA English
DT Article
DE WWI; BMI; depressive symptoms; older adults
ID BODY-MASS INDEX; INSTRUMENTAL ACTIVITIES; OBESITY; ASSOCIATION; RISK;
   PEOPLE; DYSLIPIDEMIA; HYPERTENSION; OSTEOPOROSIS
AB Objectives: The aim of this study was to evaluate which anthropometric index, either body mass index (BMI) or weight-adjusted waist index (WWI), is more accurately associated with the prevalence of the most common chronic diseases and components of geriatric assessment in hospitalized older adults. Methods: The study included a total of 2945 hospitalized older adults (median age 82 years). The associations between the presence of chronic diseases and Comprehensive Geriatric Assessment (CGA) results were compared with WWI and BMI values. Results: The WWI was significantly higher in both sex groups suffering from hypertension, diabetes, osteoarthritis, and depression. In women, the parameter was increased among individuals with previous myocardial infarction, who presented heart failure symptoms or had chronic kidney disease diagnosed, whereas in men, among those with pulmonary diseases and osteoporosis, WWI was related to many CGA parameters oftentimes where BMI proved to fail. There was a positive correlation of WWI with the presence of depressive symptoms assessed with the geriatric depression scale (GDS) but no significant correlation with BMI. In multiple logistic regression models, WWI was a stronger predictor of depression as compared to waist circumference or the waist-to-height ratio. Conclusions: There is an association between a higher WWI and depression diagnosis as well as the presence of depressive symptoms according to the GDS in hospitalized older adults, both women and men. There is no such correlation between depression and BMI. Both high BMI and high WWI values seem to identify older patients with cardiometabolic diseases such as hypertension and diabetes. According to this study, WWI seems to be a promising indicator of depression risk and, similarly to BMI, a useful parameter for the assessment of cardiometabolic risk in older hospitalized adults.
C1 [Korycka-Bloch, Renata; Balicki, Pawel; Guligowska, Agnieszka; Soltysik, Bartlomiej K.; Kostka, Tomasz; Chrzastek, Zuzanna] Med Univ Lodz, Hlth Ageing Res Ctr, Dept Geriatr, PL-92209 Lodz, Poland.
C3 Medical University Lodz
RP Chrzastek, Z (corresponding author), Med Univ Lodz, Hlth Ageing Res Ctr, Dept Geriatr, PL-92209 Lodz, Poland.
EM renata.korycka-bloch@umed.lodz.pl; pawel.balicki@umed.lodz.pl;
   agnieszka.guligowska@umed.lodz.pl; bartlomiej.soltysik@umed.lodz.pl;
   tomasz.kostka@umed.lodz.pl; zuzanna.chrzastek@umed.lodz.pl
RI Guligowska, Agnieszka/AAS-6207-2020; Soltysik, Bartlomiej K./S-9839-2016
OI Balicki, Pawel/0009-0007-7688-3865; Guligowska,
   Agnieszka/0000-0002-6928-3892; Soltysik, Bartlomiej
   K./0000-0002-1382-3757; Chrzastek, Zuzanna/0000-0001-9562-178X; Kostka,
   Tomasz/0000-0003-0437-650X
FU Medical University of Lodz, Poland;  [503/6-077-01/503-61-001]
FX The authors were supported by grant No. 503/6-077-01/503-61-001 from the
   Medical University of Lodz, Poland.
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NR 67
TC 1
Z9 1
U1 6
U2 6
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JAN
PY 2025
VL 17
IS 1
AR 68
DI 10.3390/nu17010068
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA R8G9P
UT WOS:001393776500001
PM 39796502
OA gold
DA 2025-06-11
ER

PT J
AU Nakashiki, K
   Kisanuki, A
   Otsuji, Y
   Yoshifuku, S
   Yuasa, T
   Takasaki, K
   Kuwahara, E
   Yu, B
   Uemura, T
   Mizukami, N
   Hamasaki, S
   Minagoe, S
   Tei, C
AF Nakashiki, Kenichi
   Kisanuki, Akira
   Otsuji, Yutaka
   Yoshifuku, Shiro
   Yuasa, Toshinori
   Takasaki, Kunitsugu
   Kuwahara, Eiji
   Yu, Bo
   Uemura, Takeshi
   Mizukami, Naoko
   Hamasaki, Shuichi
   Minagoe, Shinichi
   Tei, Chuwa
TI Usefulness of a novel ultrasound transducer for continuous monitoring
   treadmill exercise echocardiography to assess coronary artery disease
SO CIRCULATION JOURNAL
LA English
DT Article
DE coronary artery disease; stress echocardiography; treadmill exercise
   test
ID DOBUTAMINE STRESS ECHOCARDIOGRAPHY; SUPINE BICYCLE EXERCISE; ISCHEMIC
   CASCADE; SYNDROME-X; MYOCARDIUM; REST
AB Background The feasibility of a novel ultrasound probe, which can be attached to the left ventricular (LV) apex chest wall and allows free rotation around its long axis direction for the continuous monitoring of LV wall motion, was tested.
   Methods and Results There were 36 subjects who had coronary artery disease (CAD). By attaching a novel ultrasound probe to the chest wall, the LV apical views were recorded during treadmill exercise stress echocardiography (Echo). The continuous monitoring of LV wall motion was satisfactorily feasible in 30 of 36 patients. The visualization rate of the overall LV segments was higher at rest (90%) compared to that during peak exercise (77%). The segments were better visualized in apical portions (90-400%) than in mid (77-96%) or basal portions (68-87%). The sensitivity, specificity, and accuracy for detecting CAD were 61, 100 and 77%, respectively. The wall motion score index 3 and 6 min after exercise decreased significantly compared to those at peak exercise. The number of segments with dyssynergy was highest at the peak exercise. Ischemic ST-T depression on electrocardiography was observed only at peak stress periods.
   Conclusions Continuous monitoring treadmill exercise Echo using a novel ultrasound probe seems feasible for the non-invasive and physiological assessment of CAD.
C1 Kagoshima Univ Hosp, Dept Cardiovasc Med, Kagoshima, Japan.
C3 Kagoshima University
RP Nakashiki, K (corresponding author), Kagoshima Univ, Grad Sch Med, Dept Cardiovasc Resp & Metab Med, 8-35-1 Sakuragaoka, Kagoshima 8908520, Japan.
EM kenchan@js7.so-net.ne.jp
RI Kuwahara, Eiji/AAH-4106-2019
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NR 41
TC 5
Z9 7
U1 0
U2 0
PU JAPANESE CIRCULATION SOC
PI TOYKO
PA 18TH FLOOR IMPERIAL HOTEL TOWER, 1-1-1 UCHISAIWAI-CHO CHIYODA-KU, TOYKO,
   100-0011, JAPAN
SN 1346-9843
EI 1347-4820
J9 CIRC J
JI Circ. J.
PD OCT
PY 2006
VL 70
IS 10
BP 1297
EP 1302
DI 10.1253/circj.70.1297
PG 6
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 089VC
UT WOS:000240908400011
PM 16998262
OA Bronze
DA 2025-06-11
ER

PT J
AU Suzuki, M
   Kon, K
   Ikejima, K
   Arai, K
   Uchiyama, A
   Aoyama, T
   Yamashina, S
   Ueno, T
   Watanabe, S
AF Suzuki, Maiko
   Kon, Kazuyoshi
   Ikejima, Kenichi
   Arai, Kumiko
   Uchiyama, Akira
   Aoyama, Tomonori
   Yamashina, Shunhei
   Ueno, Takashi
   Watanabe, Sumio
TI The Chemical Chaperone 4-Phenylbutyric Acid Prevents Alcohol-Induced
   Liver Injury in Obese KK-A<SUP>y</SUP> Mice
SO ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
LA English
DT Article
DE Alcoholic Liver Disease; Obesity; Metabolic Syndrome; Endoplasmic
   Reticulum Stress; Oxidative Stress
ID ENDOPLASMIC-RETICULUM STRESS; CLINICAL-PRACTICE GUIDELINES; SHORT-TERM
   SURVIVAL; FATTY LIVER; ER-STRESS; OXIDATIVE STRESS; METABOLIC
   STEATOHEPATITIS; DIETARY STEATOHEPATITIS; CYTOCHROME P4502E1; MOUSE
   MODEL
AB Background Co-occurrence of metabolic syndrome and chronic alcohol consumption is increasing worldwide. The present study investigated the effect of the chemical chaperone 4-phenylbutyric acid (PBA)-which has been shown to alleviate dietary steatohepatitis caused by endoplasmic reticulum (ER) stress-on chronic-plus-binge ethanol (EtOH)-induced liver injury in a mouse model of obesity. Methods Male KK-A(y) mice (8 weeks old) were fed a Lieber-DeCarli diet (5% EtOH) for 10 days. Some mice were given PBA intraperitoneally (120 mg/kg body weight, daily) during the experimental period. On day 11, mice were gavaged with a single dose of EtOH (4 g/kg body weight). Control mice were given a dextrin gavage after being pair-fed a control diet. All mice were then serially euthanized before or at 9 hours after gavage. Results Chronic-plus-binge EtOH intake induced massive hepatic steatosis along with hepatocyte apoptosis and inflammation, which was reversed by PBA treatment. Administration of PBA also suppressed chronic-plus-binge EtOH-induced up-regulation of ER stress-related genes including binding immunoglobulin protein (Bip), unspliced and spliced forms of X-box-binding protein-1 (uXBP1 and sXBP1, respectively), inositol trisphosphate receptor (IP3R), and C/EBP homologous protein (CHOP). Further, it blocked chronic-plus-binge EtOH-induced expression of the oxidative stress marker heme oxygenase-1 (HO-1) and 4-hydroxynonenal. Chronic EtOH alone (without binge) increased Bip and uXBP1, but it did not affect those of sXBP1, IP3R, CHOP, or HO-1. PBA reversed the prebinge expression of these genes to control levels, but it did not affect chronic EtOH-induced hepatic activity of cytochrome P450 2E1. Conclusions Binge EtOH intake after chronic consumption induces massive ER stress-related oxidative stress and liver injury in a mouse model of obesity through dysregulation of the unfolded protein response. PBA ameliorated chronic-plus-binge EtOH-induced liver injury by reducing ER and oxidative stress after an EtOH binge.
C1 [Suzuki, Maiko; Kon, Kazuyoshi; Ikejima, Kenichi; Arai, Kumiko; Uchiyama, Akira; Aoyama, Tomonori; Yamashina, Shunhei; Watanabe, Sumio] Juntendo Univ, Grad Sch Med, Dept Gastroenterol, Tokyo, Japan.
   [Ueno, Takashi] Juntendo Univ, Lab Prote & Med Sci, Res Support Ctr, Lab Prote & Biomol Sci, Tokyo, Japan.
C3 Juntendo University; Juntendo University
RP Kon, K (corresponding author), Juntendo Univ, Grad Sch Med, Dept Gastroenterol, Bunkyo Ku, 2-1-1 Hongo, Tokyo 1138421, Japan.
EM kazukon@juntendo.ac.jp
RI Kon, Kazuyoshi/AAV-7832-2020
OI Kon, Kazuyoshi/0000-0002-1127-2218
FU Japan Society for the Promotion of Science KAKENHI [15K09023, 16H05293];
   [28-39]; Grants-in-Aid for Scientific Research [16H05293, 15K09023]
   Funding Source: KAKEN
FX This work was supported in part by the Japan Society for the Promotion
   of Science KAKENHI (no. 15K09023 to KI and no. 16H05293 to SW) and a
   grant for Cross-disciplinary Collaboration, Juntendo University (no.
   28-39).
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NR 58
TC 9
Z9 10
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0145-6008
EI 1530-0277
J9 ALCOHOL CLIN EXP RES
JI Alcoholism (NY)
PD APR
PY 2019
VL 43
IS 4
BP 617
EP 627
DI 10.1111/acer.13982
PG 11
WC Substance Abuse
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Substance Abuse
GA HR2AV
UT WOS:000462938800007
PM 30748014
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Chen, JH
   Tan, LW
   Long, Z
   Wang, LF
   Hu, L
   Yang, D
AF Chen, Jinhong
   Tan, Liwen
   Long, Zhou
   Wang, Lifeng
   Hu, Li
   Yang, Dong
TI Drug-naive patients with schizophrenia have metabolic disorders that are
   not associated with polymorphisms in the LEP (-2548G/A) and 5-HTR2C
   (-759C/T) genes
SO INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY
LA English
DT Article
DE Schizophrenia; metabolic syndrome; antipsychotic drugs; leptin; 5-HTR2C
ID 5-HT2C RECEPTOR GENE; GLUCOSE-TOLERANCE; EXCESS MORTALITY; PROMOTER
   REGION; 1ST EPISODE; WEIGHT-GAIN; OBESITY; HTR2C; RISK; ANTIPSYCHOTICS
AB Schizophrenia is a mental disorder that is primarily caused by polygenic mutations. Schizophrenic patients are more likely to suffer from metabolic syndrome (MS), which is usually accompanied by polymorphisms in the leptin (LEP) gene at the -2548 (G/A) locus and the 5-hydroxytryptamine receptor 2C (5-HTR2C) gene at the -759 (C/T) locus. Hence, we hypothesized an association between these polymorphisms and schizophrenia incidence. A total of 148 drug-naive schizophrenic patients and 165 normal controls were enrolled in the study. Blood glucose levels, lipid levels, and other metabolic markers were measured. MALDI-TOFMS was performed to analyse genotypes of LEP and 5-HTR2C at -2548 (G/A) and -759 (C/T) loci, respectively. Patients with first-episode schizophrenia showed higher levels of fasting blood glucose and the 2-h postprandial glucose (2 hPG), as well as higher insulin resistance indices, but showed lower high-density lipoprotein cholesterol (HDL-C) levels compared to those of the controls. The above results were partly observed when the analysis was performed separately in males and females. Schizophrenic and healthy participants showed no significant differences in the genotypes and allele frequencies in the leptin and 5-HTR2C genes. Patients with varying genotypes of -2548 (G/A) in the leptin gene and -759 (C/T) in the 5-HTR2C gene showed no differences in the indices related to the glucose and lipid metabolism. Taken together, drug-naive schizophrenia patients showed some incidence of metabolic disorders, but polymorphisms in the LEP (-2548G/A) and 5-HTR2C (-759C/T) genes were not associated with schizophrenia or metabolic disorders.
C1 [Chen, Jinhong; Hu, Li; Yang, Dong] Brain Hosp Hunan Prov, Dept Sleeping Disorders & Neurosis, Changsha, Hunan, Peoples R China.
   [Long, Zhou; Wang, Lifeng] Cent S Univ, Dept Clin Psychol, Xiangya Hosp 3, Changsha, Hunan, Peoples R China.
   [Tan, Liwen] Cent S Univ, Dept Clin Psychol, Xiangya Hosp 2, Changsha 410008, Hunan, Peoples R China.
C3 Central South University; Central South University
RP Tan, LW (corresponding author), Cent S Univ, Dept Clin Psychol, Xiangya Hosp 2, Changsha 410008, Hunan, Peoples R China.
EM tanliwen211@163.com
FU National Natural Science Foundation of China on Evaluation and Related
   Mechanism of Metabolic Syndrome in Schizophrenic Patients and their
   First-degree Relatives [30971051]
FX This study was funded by the National Natural Science Foundation of
   China on Evaluation and Related Mechanism of Metabolic Syndrome in
   Schizophrenic Patients and their First-degree Relatives (NO. 30971051).
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NR 46
TC 1
Z9 1
U1 1
U2 4
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 1936-2625
J9 INT J CLIN EXP PATHO
JI Int. J. Clin. Exp. Pathol.
PY 2018
VL 11
IS 12
BP 5969
EP 5980
PG 12
WC Oncology; Pathology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Pathology
GA HG0LJ
UT WOS:000454636600045
PM 31949685
DA 2025-06-11
ER

PT J
AU Zhou, TH
   Pu, CC
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   Zhang, D
   Huang, BJ
   Cheng, Z
   Shi, C
   Yu, X
AF Zhou, Tianhang
   Pu, Chengcheng
   Huang, Zetao
   Gao, Tianqi
   Zhou, Enpeng
   Zheng, Yue
   Zhang, Dan
   Huang, Bingjie
   Cheng, Zhang
   Shi, Chuan
   Yu, Xin
TI Weight changes following treatment with aripiprazole, risperidone and
   olanzapine: A 12-month study of first-episode schizophrenia patients in
   China
SO ASIAN JOURNAL OF PSYCHIATRY
LA English
DT Article
DE Schizophrenia; Weight gain; Antipsychotic; Metabolic Syndrome; China
ID SYNDROME SCALE PANSS; NONPHARMACOLOGICAL INTERVENTIONS;
   CARDIOVASCULAR-DISEASE; PSYCHOTIC DISORDERS; METABOLIC SYNDROME;
   CLINICAL-TRIAL; GAIN; RISK; ASSOCIATION; MORTALITY
AB Objectives: This study aimed to assess weight changes following antipsychotic treatment in first-episode schizo-phrenia (FES) patients and make a comparison of aripiprazole, risperidone and olanzapine. Predictors for long-term clinically relevant weight gain (CRW, >= 7%) were examined.Methods: We carried out a second analysis of data from the Chinese First-Episode Schizophrenia Trial. Repeated measures general linear model (GLM) statistics were used to compare body weight at each follow-up point (month of 1, 2, 3, 6, 9and 12). Logistic regression models were constructed to evaluate possible predictors for CRW. Results: Body weight increased with an average rate of 0.93 % per month, with the fastest growth rate occurring in first 3 months. CRW was observed in 79 % of patients. Participants from olanzapine group showed signifi-cantly higher weight gain than risperidone group and aripiprozole group. Repeated measures GLM revealed a significant main effect of time (p < 0.001) and asignificant time*group interaction was revealed (p < 0.001), while the between-subject group effect was not statistically significant (p = 0.272). Multivariate logistic regressionmodel showed that with smaller baseline BMI (OR = 1.33, p < 0.001), with a family history of mental disorder (OR = 5.08, p = 0.004), receiving olanzapine (OR = 2.35, p = 0.001), and CRW at first-month (OR = 4.29, p = 0.032) were independent predictors for first-year CRW.Conclusion: Antipsychotics are associated with a clinically significant weight gain in FES patients, which occurs mostly in first 3 months. Aripiprazole might not be an ideal choice in terms of long-term metabolic side-effects. Early and close metabolic monitoring should accompany antipsychotic prescription.
C1 [Zhou, Tianhang; Pu, Chengcheng; Huang, Zetao; Gao, Tianqi; Zhou, Enpeng; Zheng, Yue; Zhang, Dan; Huang, Bingjie; Cheng, Zhang; Shi, Chuan; Yu, Xin] Peking Univ, Peking Univ Hosp 6, Inst Mental Hlth, Natl Clin Res Ctr Mental Disorders,Clin Res Ctr,NH, Beijing, Peoples R China.
   [Yu, Xin] 51 Huayuanbeilu, Beijing 100191, Peoples R China.
C3 Peking University
RP Yu, X (corresponding author), 51 Huayuanbeilu, Beijing 100191, Peoples R China.
EM yuxin@bjmu.edu.cn
RI ZHou, Tianhang/HNQ-8900-2023
OI pu, chengcheng/0000-0002-1117-9531
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NR 46
TC 4
Z9 4
U1 0
U2 7
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1876-2018
EI 1876-2026
J9 ASIAN J PSYCHIATR
JI Asian J. Psychiatr.
PD JUN
PY 2023
VL 84
AR 103594
DI 10.1016/j.ajp.2023.103594
EA APR 2023
PG 7
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychiatry
GA F7MR9
UT WOS:000984153400001
PM 37094459
DA 2025-06-11
ER

PT J
AU Rajagopalan, G
   Chandrasekaran, SP
   Venkatraman, AC
AF Rajagopalan, Geetha
   Chandrasekaran, Sathiya Priya
   Venkatraman, Anuradha Carani
TI Troxerutin attenuates diet-induced oxidative stress, impairment of
   mitochondrial biogenesis and respiratory chain complexes in mice heart
SO CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
LA English
DT Article
DE high fat high fructose diet; metabolic syndrome; mitochondrial
   biogenesis; mitochondrial dynamics; oxidative stress; troxerutin
ID CELL-DEATH; DYSFUNCTION; CLONING; HUMANS; REGION; MOUSE; GENE; UCP3
AB Mitochondrial abnormality is thought to play a key role in cardiac disease originating from the metabolic syndrome (MS). We evaluated the effect of troxerutin (TX), a semi-synthetic derivative of the natural bioflavanoid rutin, on the respiratory chain complex activity, oxidative stress, mitochondrial biogenesis and dynamics in heart of high fat, high fructose diet (HFFD) -induced mouse model of MS. Adult male Mus musculus mice of body weight 25-30g were fed either control diet or HFFD for 60days. Mice from each dietary regimen were divided into two groups on the 16th day and were treated or untreated with TX (150mg/kg body weight [bw], per oral) for the next 45days. At the end of experimental period, respiratory chain complex activity, uncoupling proteins (UCP)-2 and -3, mtDNA content, mitochondrial biogenesis and dynamics, oxidative stress markers and reactive oxygen species (ROS) generation were analyzed. Reduced mtDNA abundance with alterations in the expression of genes related to mitochondrial biogenesis and fission and fusion processes were observed in HFFD-fed mice. Disorganized and smaller mitochondria, reduction in complexes I, III and IV activities (by about 55%) and protein levels of UCP-2 (52%) and UCP-3 (46%) were noted in these mice. TX administration suppressed oxidative stress, improved the oxidative capacity and biogenesis and restored fission/fusion imbalance in the cardiac mitochondria of HFFD-fed mice. TX protects the myocardium by modulating the putative molecules of mitochondrial biogenesis and dynamics and by its anti-oxidant function in a mouse model of MS.
C1 [Rajagopalan, Geetha; Chandrasekaran, Sathiya Priya; Venkatraman, Anuradha Carani] Annamalai Univ, Dept Biochem & Biotechnol, Chidambaram, Tamil Nadu, India.
C3 Annamalai University
RP Venkatraman, AC (corresponding author), Annamalai Univ, Dept Biochem & Biotechnol, Chidambaram, Tamil Nadu, India.
EM cvaradha@yahoo.com
RI Venkatraman, Anuradha/U-8717-2019; Chandrasekaran, Sathiya
   Priya/H-3718-2018
OI Carani Venkatraman, Anuradha/0000-0001-9924-2533; Chandrasekaran,
   Sathiya Priya/0000-0002-1943-1244
FU Indian Council of Medical Research
FX Indian Council of Medical Research
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NR 38
TC 21
Z9 21
U1 2
U2 10
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1440-1681
J9 CLIN EXP PHARMACOL P
JI Clin. Exp. Pharmacol. Physiol.
PD JAN
PY 2017
VL 44
IS 1
BP 103
EP 113
DI 10.1111/1440-1681.12671
PG 11
WC Pharmacology & Pharmacy; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Physiology
GA EI4YD
UT WOS:000392499000012
PM 27626906
DA 2025-06-11
ER

PT J
AU Dreher, ML
AF Dreher, Mark L.
TI Whole Fruits and Fruit Fiber Emerging Health Effects
SO NUTRIENTS
LA English
DT Review
DE prebiotic effects; gastrointestinal health; weight management;
   cardiovascular disease; diabetes; metabolic syndrome; successful aging;
   cancer; psychological well-being; depression; asthma; bone mineral
   density
ID INFLAMMATORY-BOWEL-DISEASE; DOSE-RESPONSE METAANALYSIS; INTAKE REDUCES
   RISK; CHAIN FATTY-ACID; TYPE-2 DIABETES-MELLITUS; DIETARY ENERGY
   DENSITY; IN-VITRO FERMENTATION; BONE-MINERAL DENSITY; VEGETABLE
   CONSUMPTION; BLOOD-PRESSURE
AB Less than 10% of most Western populations consume adequate levels of whole fruits and dietary fiber with typical intake being about half of the recommended levels. Evidence of the beneficial health effects of consuming adequate levels of whole fruits has been steadily growing, especially regarding their bioactive fiber prebiotic effects and role in improved weight control, wellness and healthy aging. The primary aim of this narrative review article is to examine the increasing number of health benefits which are associated with the adequate intake of whole fruits, especially fruit fiber, throughout the human lifecycle. These potential health benefits include: protecting colonic gastrointestinal health (e.g., constipation, irritable bowel syndrome, inflammatory bowel diseases, and diverticular disease); promoting long-term weight management; reducing risk of cardiovascular disease, type 2 diabetes and metabolic syndrome; defending against colorectal and lung cancers; improving odds of successful aging; reducing the severity of asthma and chronic obstructive pulmonary disease; enhancing psychological well-being and lowering the risk of depression; contributing to higher bone mineral density in children and adults; reducing risk of seborrheic dermatitis; and helping to attenuate autism spectrum disorder severity. Low whole fruit intake represents a potentially more serious global population health threat than previously recognized, especially in light of the emerging research on whole fruit and fruit fiber health benefits.
C1 [Dreher, Mark L.] Nutr Sci Solut LLC, Wimberley, TX 78676 USA.
RP Dreher, ML (corresponding author), Nutr Sci Solut LLC, Wimberley, TX 78676 USA.
EM mdreher@nutriscisolutions.com
FU Hass Avocado Board
FX Funding was provided by the Hass Avocado Board, which had no input as to
   the content of this manuscript.
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NR 356
TC 191
Z9 207
U1 10
U2 60
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD DEC
PY 2018
VL 10
IS 12
AR 1833
DI 10.3390/nu10121833
PG 54
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nutrition & Dietetics
GA HG6EG
UT WOS:000455073200014
PM 30487459
OA gold, Green Published, Green Submitted
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Akoumianakis, I
   Antoniades, C
AF Akoumianakis, Ioannis
   Antoniades, Charalambos
TI Impaired Vascular Redox Signaling in the Vascular Complications of
   Obesity and Diabetes Mellitus
SO ANTIOXIDANTS & REDOX SIGNALING
LA English
DT Review
DE vascular disease; vascular redox signaling; oxidative stress; obesity;
   insulin resistance
ID PROTEIN-KINASE-C; PERIVASCULAR ADIPOSE-TISSUE; GLYCATION-END-PRODUCTS;
   NITRIC-OXIDE SYNTHASE; OXIDATIVE STRESS; NADPH OXIDASE; ENDOTHELIAL
   DYSFUNCTION; INSULIN-RESISTANCE; CARDIOVASCULAR-DISEASE; METABOLIC
   SYNDROME
AB Significance: Oxidative stress, a crucial regulator of vascular disease pathogenesis, may be involved in the vascular complications of obesity, systemic insulin resistance (IR), and diabetes mellitus (DM). Recent Advances: Excessive production of reactive oxygen species in the vascular wall has been linked with vascular disease pathogenesis. Recent evidence has revealed that vascular redox state is dysregulated in cases of obesity, systemic IR, and DM, potentially participating in the well-known vascular complications of these disease entities. Critical Issues: The detrimental effects of obesity and the metabolic syndrome on vascular biology have been extensively described at a clinical level. Further, vascular oxidative stress has often been associated with the presence of obesity and IR as well as with a variety of detrimental vascular phenotypes. However, the mechanisms of vascular redox state regulation under conditions of obesity and systemic IR, as well as their clinical relevance, are not adequately explored. In addition, the notion of vascular IR, and its relationship with systemic parameters of obesity and systemic IR, is not fully understood. In this review, we present all the important components of vascular redox state and the evidence linking oxidative stress with obesity and IR. Future Directions: Future studies are required to describe the cellular effects and the translational potential of vascular redox state in the context of vascular disease. In addition, further elucidation of the direct vascular effects of obesity and IR is required for better management of the vascular complications of DM. Antioxid. Redox Signal. 00, 000-000.
C1 [Akoumianakis, Ioannis; Antoniades, Charalambos] Univ Oxford, Div Cardiovasc Med, Oxford, England.
C3 University of Oxford
RP Antoniades, C (corresponding author), Univ Oxford, John Radcliffe Hosp, Div Cardiovasc Med, CVM L6 West Wing,Headley Way, Oxford OX3 9DU, England.
EM antoniad@well.ox.ac.uk
RI Akoumianakis, Ioannis/ACD-9816-2022
OI Akoumianakis, Ioannis/0000-0002-4674-0210; Antoniades,
   Charalambos/0000-0002-6983-5423
FU British Heart Foundation [FS/16/15/32047, PG/13/56/30383]; National
   Institute for Health Research Oxford Biomedical Research Centre;
   European Commission (ITN network RADOX); NovoNordisk Foundation
   [NNF15CC0018486]; Alexandros S. Onassis Public Benefit Foundation
FX C.A. acknowledges support by the British Heart Foundation
   (FS/16/15/32047 and PG/13/56/30383), the National Institute for Health
   Research Oxford Biomedical Research Centre, the European Commission (ITN
   network RADOX), and the NovoNordisk Foundation (NNF15CC0018486). I.A.
   acknowledges support by the Alexandros S. Onassis Public Benefit
   Foundation.
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NR 218
TC 28
Z9 29
U1 0
U2 5
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1523-0864
EI 1557-7716
J9 ANTIOXID REDOX SIGN
JI Antioxid. Redox Signal.
PD JAN 20
PY 2019
VL 30
IS 3
BP 333
EP 353
DI 10.1089/ars.2017.7421
EA JAN 2018
PG 21
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA HE5CS
UT WOS:000422647400001
PM 29084432
DA 2025-06-11
ER

PT J
AU Bradley, JM
   Islam, KN
   Polhemus, DJ
   Donnarumma, E
   Brewster, LP
   Tao, YX
   Goodchild, TT
   Lefer, DJ
AF Bradley, Jessica M.
   Islam, Kazi N.
   Polhemus, David J.
   Donnarumma, Erminia
   Brewster, Luke P.
   Tao, Ya-Xiong
   Goodchild, Traci T.
   Lefer, David J.
TI Sustained release nitrite therapy results in myocardial protection in a
   porcine model of metabolic syndrome with peripheral vascular disease
SO AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
LA English
DT Article
DE Ossabaw swine; endothelial dysfunction; atherosclerosis; nitric oxide;
   sustained-release sodium nitrite
ID CORONARY-HEART-DISEASE; SYSTEMIC OXIDATIVE STRESS; ENDOTHELIAL
   DYSFUNCTION; OXIDE SYNTHASE; ASYMMETRIC DIMETHYLARGININE;
   ARTERIAL-DISEASE; CARDIOVASCULAR-DISEASE; ISCHEMIA; NITRATE; EVENTS
AB Metabolic syndrome (MetS) reduces endothelial nitric oxide (NO) bioavailability and exacerbates vascular dysfunction in patients with preexisting vascular diseases. Nitrite, a storage form of NO, can mediate vascular function during pathological conditions when endogenous NO is reduced. The aims of the present study were to characterize the effects of severe MetS and obesity on dyslipidemia, myocardial oxidative stress, and endothelial NO synthase (eNOS) regulation in the obese Ossabaw swine (OS) model and to examine the effects of a novel, sustained-release formulation of sodium nitrite (SR-nitrite) on coronary vascular reactivity and myocardial redox status in obese OS subjected to critical limb ischemia (CLI). After 6 mo of an atherogenic diet, obese OS displayed a MetS phenotype. Obese OS had decreased eNOS functionality and NO bioavailability. In addition, obese OS exhibited increased oxidative stress and a significant reduction in antioxidant enzymes. The efficacy of SR-nitrite therapy was examined in obese OS subjected to CLI. After 3 wk of treatment, SR-nitrite (80 mg.kg(-1).day(-1) bid po) increased myocardial nitrite levels and eNOS function. Treatment with SR-nitrite reduced myocardial oxidative stress while increasing myocardial antioxidant capacity. Ex vivo assessment of vascular reactivity of left anterior descending coronary artery segments demonstrated marked improvement in vasoreactivity to sodium nitroprusside but not to substance P and bradykinin in SR-nitrite-treated animals compared with placebo-treated animals. In conclusion, in a clinically relevant, large-animal model of MetS and CLI, treatment with SR-nitrite enhanced myocardial NO bioavailability, attenuated oxidative stress, and improved ex vivo coronary artery vasorelaxation.
C1 [Bradley, Jessica M.; Islam, Kazi N.; Polhemus, David J.; Donnarumma, Erminia; Goodchild, Traci T.; Lefer, David J.] Louisiana State Univ, Hlth Sci Ctr, Cardiovasc Ctr Excellence, New Orleans, LA 70112 USA.
   [Bradley, Jessica M.; Islam, Kazi N.; Polhemus, David J.; Donnarumma, Erminia; Goodchild, Traci T.; Lefer, David J.] Louisiana State Univ, Hlth Sci Ctr, Dept Pharmacol, New Orleans, LA 70112 USA.
   [Brewster, Luke P.] Emory Univ, Sch Med, Dept Surg, Atlanta, GA 30322 USA.
   [Brewster, Luke P.] Atlanta Vet Affairs Med Ctr, Surg & Res Serv, Decatur, GA USA.
   [Brewster, Luke P.] Georgia Inst Technol, Parker H Petit Inst Bioengn & Biosci, Atlanta, GA 30332 USA.
   [Tao, Ya-Xiong] Auburn Univ, Coll Vet Med, Dept Anat Physiol & Pharmacol, Auburn, AL 36849 USA.
C3 Louisiana State University System; Louisiana State University Health
   Sciences Center New Orleans; Louisiana State University System;
   Louisiana State University Health Sciences Center New Orleans; Emory
   University; US Department of Veterans Affairs; Veterans Health
   Administration (VHA); Atlanta VA Health Care System; University System
   of Georgia; Georgia Institute of Technology; Auburn University System;
   Auburn University
RP Bradley, JM (corresponding author), Louisiana State Univ, Hlth Sci Ctr, Cardiovasc Ctr Excellence, 533 Bolivar St,Suite 408, New Orleans, LA 70112 USA.
EM dlefe1@lsuhsc.edu
RI Lefer, David/A-6372-2012; Tao, Ya-Xiong/K-4939-2019
OI Tao, Ya-Xiong/0000-0003-4737-749X; Lefer, David/0000-0003-2293-7278;
   Donnarumma, Erminia/0000-0003-2184-5144
FU National Institutes of Health (NIH) [1-R01-HL-092141, 1-R01-HL-093579,
   1-U24-HL-094373, 1-P20-HL-113452, 1-KO8-HL-119592]; NIH [UL1-TR-000454];
   American Heart Association [13IRG14740001]; Carlyle Fraser Heart Center
   at Emory University Midtown Hospital; Emory University Department of
   Surgery; Louisiana State University Medical School Alumni Association;
   American Heart Association (AHA) [13IRG14740001] Funding Source:
   American Heart Association (AHA)
FX This work was supported by National Institutes of Health (NIH) Grants
   1-R01-HL-092141 (to D. J. Lefer), 1-R01-HL-093579 (to D. J. Lefer),
   1-U24-HL-094373 (to D. J. Lefer), 1-P20-HL-113452 (to D. J. Lefer), and
   1-KO8-HL-119592 (to L. P. Brewster) and supported in part by NIH Grant
   UL1-TR-000454 from the Clinical and Translational Science Award Program
   (to L. P. Brewster) and American Heart Association Grant 13IRG14740001
   (to L. P. Brewster). The authors are also grateful for the generous
   funding from the Carlyle Fraser Heart Center at Emory University Midtown
   Hospital, the Emory University Department of Surgery, and the Louisiana
   State University Medical School Alumni Association.
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NR 46
TC 16
Z9 16
U1 0
U2 6
PU AMER PHYSIOLOGICAL SOC
PI Rockville
PA 6120 Executive Blvd, Suite 600, Rockville, MD, UNITED STATES
SN 0363-6135
EI 1522-1539
J9 AM J PHYSIOL-HEART C
JI Am. J. Physiol.-Heart Circul. Physiol.
PD JUL 15
PY 2015
VL 309
IS 2
BP H305
EP H317
DI 10.1152/ajpheart.00163.2015
PG 13
WC Cardiac & Cardiovascular Systems; Physiology; Peripheral Vascular
   Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Physiology
GA CM8YO
UT WOS:000357990200008
PM 25957218
OA Green Published
DA 2025-06-11
ER

PT J
AU Li, HX
   Zhou, B
   Xu, L
   Liu, JL
   Zang, WJ
   Wu, SF
   Sun, HZ
AF Li, Huixia
   Zhou, Bo
   Xu, Lin
   Liu, Jiali
   Zang, Weijin
   Wu, Shufang
   Sun, Hongzhi
TI Circulating PGRN Is Significantly Associated With Systemic Insulin
   Sensitivity and Autophagic Activity in Metabolic Syndrome
SO ENDOCRINOLOGY
LA English
DT Article
ID ENDOPLASMIC-RETICULUM STRESS; FRONTOTEMPORAL LOBAR DEGENERATION;
   ADIPOKINE PROGRANULIN DEPEND; FACTOR-KAPPA-B; ADIPOSE-TISSUE;
   GROWTH-FACTOR; ER STRESS; EPITHELIN PRECURSOR; ADIPOGENIC GENES; MTOR
   INHIBITION
AB Progranulin (PGRN) is a secreted protein that has recently emerged as an important regulatory adipokine of glucose metabolism and insulin sensitivity. We report here that serum PGRN concentrations were significantly higher in patients with metabolic syndrome (MS) than in subjects without MS and correlated positively with body mass index, waist circumference, fasting insulin, fasting plasma glucose, glycated hemoglobin A(1c), triglyceride, and homeostasis model assessment of insulin resistance, and were inversely related to high-density lipoprotein cholesterol and homeostasis model assessment of beta cell function. Subgroup analysis in 32 subjects showed that elevated expression levels of PGRN were positively correlated with increased autophagy markers LC3 and Atg7 proteins in omental adipose tissue of subjects with MS. Consistent with these findings, the enhanced PGRN levels were also observed in multiple insulin-resistant cellular models, whereas PGRN-deficient adipocytes were more susceptible to insulin action and refractory to tunicamycin-induced autophagic disorders. PGRN remarkably attenuated insulin sensitivity, increased autophagic activity, and triggered endoplasmic reticulum (ER) stress in cultured human adipocytes, whereas these effects were nullified by reduction of ER stress with phenylbutyric acid chemical chaperone treatment. In addition, PGRN-induced ER stress and impaired insulin sensitivity were improved in TNFR1(-/-) cells, indicating a causative role of TNF receptor in the action of PGRN. Collectively, our findings suggest that circulating PGRN is significantly associated with systemic insulin sensitivity and autophagic activity in adipose tissue and support the notion that PGRN functions as a potential link between chronic inflammation and insulin resistance.
C1 [Li, Huixia; Zhou, Bo; Xu, Lin; Liu, Jiali; Zang, Weijin; Wu, Shufang; Sun, Hongzhi] Xi An Jiao Tong Univ, Affiliated Hosp 1, Sch Med, Key Lab Environm & Genes Related Dis,Minist Educ, Xian 710061, Shaanxi, Peoples R China.
C3 Xi'an Jiaotong University; Ministry of Education - China
RP Sun, HZ (corresponding author), Xi An Jiao Tong Univ, Coll Med, 76 Yanta West Rd, Xian 710061, Peoples R China.
EM shufangw@hotmail.com; sunhongzhi@mail.xjtu.edu.cn
OI Zhou, Bo/0000-0003-1467-6565
FU National Natural Science Foundation of China [30971392, 81170741,
   81071440, 81222026]; Ministry of Education, China (New Century Excellent
   Talents in University) [NCET-08-0435]
FX This work was supported by the programs from the National Natural
   Science Foundation of China (General Program 30971392, 81170741,
   81071440, and 81222026) and the the Ministry of Education, China (New
   Century Excellent Talents in University NCET-08-0435)
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NR 55
TC 42
Z9 44
U1 0
U2 12
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0013-7227
EI 1945-7170
J9 ENDOCRINOLOGY
JI Endocrinology
PD SEP
PY 2014
VL 155
IS 9
BP 3493
EP 3507
DI 10.1210/en.2014-1058
PG 15
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA AP8QQ
UT WOS:000342344300028
PM 24971611
OA Bronze
DA 2025-06-11
ER

PT J
AU Ruiz-Ramírez, A
   Ortiz-Balderas, E
   Gardozo-Saldaña, G
   Diaz-Diaz, E
   El-Hafidi, M
AF Ruiz-Ramirez, Angelica
   Ortiz-Balderas, Ely
   Gardozo-Saldana, Guillermo
   Diaz-Diaz, Eulises
   El-Hafidi, Mohammed
TI Glycine restores glutathione and protects against oxidative stress in
   vascular tissue from sucrose-fed rats
SO CLINICAL SCIENCE
LA English
DT Article
DE endothelial dysfunction; glutathione; nitric oxide; obesity; oxidative
   stress; vascular complication
ID FREE FATTY-ACIDS; METABOLIC SYNDROME; NAD(P)H OXIDASE; NITRIC-OXIDE;
   IN-VIVO; ENDOTHELIAL DYSFUNCTION; BUTHIONINE SULFOXIMINE; DIETARY
   GLYCINE; NADPH OXIDASES; BLOOD-PRESSURE
AB The attenuation of oxidative stress could be an important mechanism whereby the incidence of vascular complications in the MS (metabolic syndrome) may be diminished. The present study was undertaken to investigate the mechanism by which glycine, supplemented to the diet of SF (sucrose-fed) rats, modulates glutathione biosynthesis and protects against oxidative stress and altered endothelium-dependent relaxation in isolated aorta. Glycine reduced O-2(center dot-) (superoxide anion radical) release in the presence of NADPH, and decreased protein carbonyl and lipid peroxidation. This effect of glycine could be because of the increased amount of glutathione synthetase, which may be responsible for increased glutathione (GSH) content in vascular tissue from SF rats. Moreover, glycine increased the amount of Cu,Zn-SOD (copper/zinc superoxide dismutase) and eNOS (endothelial NO synthase) in aorta from SF animals. Finally, it improved the relaxation response to ACh (acetylcholine) found impaired in aortic rings from SF rats. In the presence of NAC (N-acetylcysteine), a precursor of GSH, an improved ACh-mediated aortic relaxation of aortic rings from SF rats was observed, whereas BSO (buthionine sulfoximine), an inhibitor of glutathione biosynthesis, inhibited the relaxing effect of NAC in aortas from both control and SF rats. This experiment emphasizes the role of GSH in endothelial function in SF rats. The present data suggest that glycine rectifies vascular reactivity by increasing the biosynthesis of glutathione. Glutathione protects vascular tissue against oxidative stress, and enhances the availability of NO, which exerts its relaxing effect, thus contributing to the reduction of high BP (blood pressure) in the SF rats.
C1 [Ruiz-Ramirez, Angelica; Ortiz-Balderas, Ely; El-Hafidi, Mohammed] Inst Nacl Cardiol Ignacio Chavez, Dept Cardiovasc Biomed, Mexico City 14080, DF, Mexico.
   [Gardozo-Saldana, Guillermo] Inst Nacl Cardiol Ignacio Chavez, Dept Endocrinol, Mexico City 14080, DF, Mexico.
   [Diaz-Diaz, Eulises] Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Reprod Biol, Mexico City 14000, DF, Mexico.
C3 National Institute of Cardiology - Mexico; National Institute of
   Cardiology - Mexico; Instituto Nacional de Ciencias Medicas y Nutricion
   Salvador Zubiran - Mexico
RP El-Hafidi, M (corresponding author), Inst Nacl Cardiol Ignacio Chavez, Dept Cardiovasc Biomed, Juan Badiano 1,Col Secc 16, Mexico City 14080, DF, Mexico.
EM medelhafidi@yahoo.com
RI El-Hafidi, Mohammed/AAN-4083-2021
FU Institut de Ciencia y Tecnologia del Distrito Federal, Mexico City
   (ICyTDF) [PICDS08-67]; Consejo Nacional de Ciencia y Tecnologia
   (CONACyT) [1068451]
FX This work was supported in part by the Institut de Ciencia y Tecnologia
   del Distrito Federal, Mexico City (ICyTDF) [grant number PICDS08-67] and
   by Consejo Nacional de Ciencia y Tecnologia (CONACyT) [grant number
   1068451.
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NR 61
TC 81
Z9 90
U1 0
U2 33
PU PORTLAND PRESS LTD
PI LONDON
PA CHARLES DARWIN HOUSE, 12 ROGER STREET, LONDON WC1N 2JU, ENGLAND
SN 0143-5221
EI 1470-8736
J9 CLIN SCI
JI Clin. Sci.
PD JAN
PY 2014
VL 126
IS 1-2
BP 19
EP 29
DI 10.1042/CS20130164
PG 11
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 297MA
UT WOS:000330258400002
PM 23742196
DA 2025-06-11
ER

PT J
AU Santillán, LD
   Moyano, M
   Frau, M
   Flores, O
   Siewert, S
   Zirulnick, F
   Ramirez, DC
   Giménez, MS
AF Santillan, Lucas D.
   Moyano, Marta
   Frau, Martin
   Flores, Orlando
   Siewert, Susana
   Zirulnick, Fanny
   Ramirez, Dario C.
   Gimenez, Maria S.
TI Reduced Blood Nrf-2 mRNA in Local Overweight Boys at Risk of Metabolic
   Complications: A Study in San Luis City, San Luis, Argentina
SO METABOLIC SYNDROME AND RELATED DISORDERS
LA English
DT Article
ID OXIDATIVE STRESS; INSULIN-RESISTANCE; PROTEIN CARBONYLS;
   GENE-EXPRESSION; PLASMA; OBESITY; ACTIVATION; PATHWAY; MARKERS; TARGET
AB Background: Childhood overweight (OW) is a matter of public health concern because of its long-term impact on adulthood health. NF-E2-related factor 2 (Nrf-2) regulates the antioxidant/lipogenic response to a sustained positive energy balance that prevails during weight gain. Here we aimed at studying a possible link between OW and Nrf-2-dependent antioxidant/lipogenic response in a local population of boys at risk of metabolic complications. Methods: We measured clinical and biochemical parameters related to lipid metabolism, oxidative stress, and metabolic syndrome in a population of OW boys [body mass index (BMI) percentile 85(th) and <95(th), n=22] and normal weight boys (NW; BMI percentile<85(th), n=27) from San Luis City, San Luis, Argentina. Results: Compared to NW, OW boys had lower insulin sensitivity, an altered plasma lipid profile, and increased markers of oxidative stress and inflammatory fatty acids. OW boys also had a higher atherogenic index and peripheral insulin resistance than NW boys. We also found that glutathione peroxidase activity and the reduced glutathione to oxidized glutathione ratio were lower in OW boys than NW boys, suggesting that OW boys may have an altered antioxidant response to oxidative stress. Finally, Nrf-2 expression negatively correlated with metabolic syndrome parameters in OW boys. Conclusions: Our data suggest that OW boys have a reduced antioxidant and lipogenic response to a positive energy balance, resulting in oxidative stress, insulin resistance, and risk of developing metabolic complications. Our data also provide a rationale for nutritional interventions aimed at restoring Nrf-2 expression to reduce the risk of metabolic complications in OW boys.
C1 [Santillan, Lucas D.; Zirulnick, Fanny; Gimenez, Maria S.] Natl Univ San Luis, Lab Pathol & Biol Chem, Dept Biochem & Biol Sci, RA-5700 San Luis, Argentina.
   [Santillan, Lucas D.; Zirulnick, Fanny; Gimenez, Maria S.] IMIBIO SL CONICET, San Luis, Argentina.
   [Moyano, Marta] San Luis Reg Hosp, Minist Hlth,Prov San Luis, San Luis, Argentina.
   [Frau, Martin; Flores, Orlando] Private Med Ctr San Luis, San Luis, Argentina.
   [Siewert, Susana] Natl Univ San Luis, Lab Diabet, RA-5700 San Luis, Argentina.
   [Ramirez, Dario C.] Natl Univ San Luis, Lab Expt & Therapeut Med IMIBIO SL CONICET, RA-5700 San Luis, Argentina.
   [Ramirez, Dario C.] Natl Univ San Luis, Dept Biochem & Biol Sci, RA-5700 San Luis, Argentina.
C3 Universidad Nacional de San Luis; Consejo Nacional de Investigaciones
   Cientificas y Tecnicas (CONICET); Universidad Nacional de San Luis;
   Universidad Nacional de San Luis; Universidad Nacional de San Luis
RP Giménez, MS (corresponding author), Natl Univ San Luis, IMIBIO SL CONICET, Ave Ejercito Andes 950, RA-5700 San Luis, Argentina.
EM ramirezlabimibiosl@ymail.com; marisofigime44@gmail.com
RI Flores, Orlando/AAT-1887-2020; RAMIREZ, DARIO/K-3312-2013
OI RAMIREZ, DARIO/0000-0001-6725-3326; Gimenez, Maria
   Sofia/0000-0003-1312-0661
FU National University of San Luis [8104]; PIP CONICET [4931]
FX Authors thank Sandra E. Gomez-Mejiba for helping in the editing of this
   manuscript and Dr. Isabel Gimenez for assistance with statistical
   analyses. D. C. R. is an affiliate Investigator of the National
   Institute of Environmental Health Sciences, National Institutes of
   Health, U.S. Department of Health and Human Services. This research was
   supported by the National University of San Luis to M. S. G. (grant
   #8104: Nutrition, Environment and Cell Metabolism) and PIP CONICET 4931
   to M.S.G.
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NR 35
TC 4
Z9 4
U1 0
U2 1
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-4196
EI 1557-8518
J9 METAB SYNDR RELAT D
JI Metab. Syndr. Relat. Disord.
PD OCT 1
PY 2013
VL 11
IS 5
BP 359
EP 365
DI 10.1089/met.2012.0155
PG 7
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 220JZ
UT WOS:000324580800009
PM 23809001
OA Green Published
DA 2025-06-11
ER

PT J
AU Glaus, J
   Kang, SJ
   Guo, W
   Lamers, F
   Strippoli, MPF
   Leroux, A
   Dey, D
   Plessen, KJ
   Vaucher, J
   Vollenweider, P
   Zipunnikov, V
   Merikangas, KR
   Preisig, M
AF Glaus, Jennifer
   Kang, Sun Jung
   Guo, Wei
   Lamers, Femke
   Strippoli, Marie-Pierre F.
   Leroux, Andrew
   Dey, Debangan
   Plessen, Kerstin J.
   Vaucher, Julien
   Vollenweider, Peter
   Zipunnikov, Vadim
   Merikangas, Kathleen R.
   Preisig, Martin
TI Objectively assessed sleep and physical activity in depression subtypes
   and its mediating role in their association with cardiovascular risk
   factors
SO JOURNAL OF PSYCHIATRIC RESEARCH
LA English
DT Article
DE Depressive disorder subtypes; Atypical depression; BMI; Metabolic
   syndrome; Actigraphy; Epidemiology
ID METABOLIC SYNDROME; DIAGNOSTIC INTERVIEW; INFLAMMATORY MARKERS; ATYPICAL
   FEATURES; DISORDERS; DISTURBANCES; SYMPTOMS; MOOD; METAANALYSIS;
   RELIABILITY
AB The aims of this study were to investigate the associations of major depressive disorder (MDD) and its subtypes (atypical, melancholic, combined, unspecified) with actigraphy-derived measures of sleep, physical activity and circadian rhythms; and test the potentially mediating role of sleep, physical activity and circadian rhythms in the well-established associations of the atypical MDD subtype with Body Mass Index (BMI) and the metabolic syn-drome (MeS). The sample consisted of 2317 participants recruited from an urban area, who underwent comprehensive somatic and psychiatric evaluations. MDD and its subtypes were assessed via semi-structured diagnostic interviews. Sleep, physical activity and circadian rhythms were measured using actigraphy. MDD and its subtypes were associated with several actigraphy-derived variables, including later sleep midpoint, low physical activity, low inter-daily stability and larger intra-individual variability of sleep duration and relative amplitude. Sleep midpoint and physical activity fulfilled criteria for partial mediation of the association between atypical MDD and BMI, and physical activity also for partial mediation of the association between atypical MDD and MeS. Our findings confirm associations of MDD and its atypical subtype with sleep and physical activity, which are likely to partially mediate the associations of atypical MDD with BMI and MeS, although most of these associations are not explained by sleep and activity variables. This highlights the need to consider atypical MDD, sleep and sedentary behavior as cardiovascular risk factors.
C1 [Glaus, Jennifer; Plessen, Kerstin J.] Lausanne Univ Hosp CHUV, Dept Psychiat, Div Child & Adolescent Psychiat, Lausanne, Switzerland.
   [Glaus, Jennifer; Plessen, Kerstin J.; Vaucher, Julien; Vollenweider, Peter] Univ Lausanne, Lausanne, Switzerland.
   [Kang, Sun Jung; Guo, Wei; Dey, Debangan; Merikangas, Kathleen R.] Natl Inst Mental Hlth, Intramural Res Program, Genet Epidemiol Res Branch, 35 Convent Dr,MSC 3720,Bldg 35A,Room 2E422A, Bethesda, MD USA.
   [Lamers, Femke] Vrije Univ Amsterdam, Amsterdam UMC Locat, Dept Psychiat, Boelalaan 1117, Amsterdam, Netherlands.
   [Lamers, Femke] Amsterdam Publ Hlth, Mental Hlth Program, Amsterdam, Netherlands.
   [Strippoli, Marie-Pierre F.; Preisig, Martin] Lausanne Univ Hosp, Ctr Res Psychiat Epidemiol & Psychopathol, Dept Psychiat, Prilly, Switzerland.
   [Strippoli, Marie-Pierre F.; Preisig, Martin] Univ Lausanne, Prilly, Switzerland.
   [Leroux, Andrew] Univ Colorado, Dept Biostat & Informat, Anshutz Med Campus, Aurora, CO USA.
   [Vaucher, Julien; Vollenweider, Peter] Lausanne Univ Hosp, Dept Internal Med, Lausanne, Switzerland.
   [Zipunnikov, Vadim] Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD USA.
   [Glaus, Jennifer] Lausanne Univ Hosp, Dept Psychiat, Div Child & Adolescent Psychiat, Ave Echallens 9, CH-1004 Lausanne, Switzerland.
C3 University of Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV);
   University of Lausanne; National Institutes of Health (NIH) - USA; NIH
   National Institute of Mental Health (NIMH); Vrije Universiteit
   Amsterdam; University of Lausanne; University of Colorado System;
   University of Colorado Anschutz Medical Campus; University of Lausanne;
   Centre Hospitalier Universitaire Vaudois (CHUV); Johns Hopkins
   University; Johns Hopkins Bloomberg School of Public Health; University
   of Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV)
RP Glaus, J (corresponding author), Lausanne Univ Hosp CHUV, Dept Psychiat, Div Child & Adolescent Psychiat, Lausanne, Switzerland.; Glaus, J (corresponding author), Lausanne Univ Hosp, Dept Psychiat, Div Child & Adolescent Psychiat, Ave Echallens 9, CH-1004 Lausanne, Switzerland.
EM jennifer.glaus@chuv.ch
RI Dey, Debangan/KAM-5399-2024; Glaus, Jennifer/C-7887-2017; Lamers,
   Femke/G-5161-2012; Preisig, Martin/H-3441-2016; Vaucher,
   Julien/LXB-4884-2024; Vollenweider, Peter/Q-4603-2016
OI Glaus, Jennifer/0000-0001-8883-9473; Vollenweider,
   Peter/0000-0002-0765-896X; Dey, Debangan/0000-0002-2579-5693; Vaucher,
   Julien/0000-0002-3230-3693; Strippoli, Marie-Pierre/0000-0003-3053-484X
FU National Institute of Health Intramural Research Program [ZIA MH002954];
   GlaxoSmithKline; Faculty of Biology and Medicine of Lausanne; Swiss
   National Science Foundation [3200B0-105993, 3200B0-118308,
   33CSCO-122661, 33CS30-139468, 33CS30-148401, 33CS30_177535,
   3247730_204523]; Swiss Personalized Health Network (project: Swiss Aging
   Citizen Reference)~
FX The ColausIPsyColaus study is a core site of the mobile Motor Activity
   Research Activity Consortium for Health (mMARCH) Network coordinated by
   the National Institute of Health Intramural Research Program (ZIA
   MH002954) . mMARCH team completed the data extraction, analyses and
   standardization of the administration of the mobile technology in the
   study. The ColausIPsyColaus study was supported by research grants from
   GlaxoSmithKline, the Faculty of Biology and Medicine of Lausanne, the
   Swiss National Science Foundation (grants 3200B0-105993, 3200B0-118308,
   33CSCO-122661, 33CS30-139468, 33CS30-148401, 33CS30_177535 and
   3247730_204523) and the Swiss Personalized Health Network (project:
   Swiss Aging Citizen Reference)& nbsp;
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NR 83
TC 6
Z9 7
U1 2
U2 6
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-3956
EI 1879-1379
J9 J PSYCHIATR RES
JI J. Psychiatr. Res.
PD JUL
PY 2023
VL 163
BP 325
EP 336
DI 10.1016/j.jpsychires.2023.05.042
EA MAY 2023
PG 12
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA K0TB5
UT WOS:001013647600001
PM 37253320
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Russell, JC
   Proctor, SD
   Kelly, SE
   Brindley, DN
AF Russell, James C.
   Proctor, Spencer D.
   Kelly, Sandra E.
   Brindley, David N.
TI Pair feeding-mediated changes in metabolism:: stress response and
   pathophysiology in insulin-resistant, atherosclerosis-prone JCR:LA-cp
   rats
SO AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
LA English
DT Article
DE metabolic syndrome; stress; fatty acids; vascular function; myocardial
   lesions
ID CARDIOVASCULAR-DISEASE; ADIPOSE-TISSUE; SERUM-INSULIN; FATTY-ACIDS;
   OBESE; TRIACYLGLYCEROL; SENSITIVITY; ZUCKER; GLUCOSE; MUSCLE
AB Rats of the JCR: LA-cp strain, which are homozygous for the cp gene (cp/cp), are obese, insulin-resistant, and hyperinsulinemic. They exhibit associated micro- and macrovascular disease and end-stage ischemic myocardial lesions and are highly stress sensitive. We subjected male cp/cp rats to pair feeding (providing the rats each day with the amount of food eaten by matched freely fed animals), a procedure that alters the diurnal feeding pattern, leading to a state of intermittent caloric restriction. Effects on insulin, glucose, and lipid metabolism, response to restraint stress, aortic contractile/relaxant response, and myocardial lesion frequency were investigated. Pair-fed young (12-wk-old) cp/cp rats had lower insulin and glucose levels (basal and following restraint), consistent with increased insulin sensitivity, but a greater increase in plasma nonesterified fatty acids in response to restraint. These effects were unrelated to lipolytic rates in adipose tissue but may be related to reduced fatty acid oxidation in skeletal muscle. Older (24-wk-old) pair-fed cp/cp rats had significantly reduced plasma triglyceride levels, improved micro- and macrovascular function, and reduced severity of ischemic myocardial lesions. These changes indicate a significant amelioration of end-stage disease processes in this animal model and the complexity of metabolic/physiological responses in studies involving alterations in food intake. The effects illustrate the sensitivity of the JCR: LA-cp rat, an animal model for the metabolic syndrome and associated cardiovascular disease, to the environmental and experimental milieu. Similar stress-related mechanisms may play a role in metabolically induced cardiovascular disease in susceptible human beings.
C1 [Russell, James C.; Proctor, Spencer D.; Kelly, Sandra E.] Univ Alberta, Alberta Inst Human Nutr, Agr Forestry Ctr 4 10, Metab & Cardiovasc Dis Lab, Edmonton, AB T6G 2P5, Canada.
   [Brindley, David N.] Univ Alberta, Dept Biochem, Signal Transduct Res Grp, Edmonton, AB T6G 2P5, Canada.
C3 University of Alberta; University of Alberta
RP Russell, JC (corresponding author), Univ Alberta, Alberta Inst Human Nutr, Agr Forestry Ctr 4 10, Metab & Cardiovasc Dis Lab, Edmonton, AB T6G 2P5, Canada.
EM Jim.Russell@ualberta.ca
RI Proctor, Spencer/F-2774-2012
OI Proctor, Spencer/0000-0002-7597-5262
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NR 55
TC 14
Z9 20
U1 0
U2 1
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0193-1849
EI 1522-1555
J9 AM J PHYSIOL-ENDOC M
JI Am. J. Physiol.-Endocrinol. Metab.
PD JUN
PY 2008
VL 294
IS 6
BP E1078
EP E1087
DI 10.1152/ajpendo.90257.2008
PG 10
WC Endocrinology & Metabolism; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Physiology
GA 309OD
UT WOS:000256469200009
PM 18413677
DA 2025-06-11
ER

PT J
AU Feng, XJ
   Yu, W
   Li, XD
   Zhou, FF
   Zhang, WL
   Shen, Q
   Li, JX
   Zhang, C
   Shen, PP
AF Feng, Xiujing
   Yu, Wen
   Li, Xinda
   Zhou, Feifei
   Zhang, Wenlong
   Shen, Qi
   Li, Jianxin
   Zhang, Can
   Shen, Pingping
TI Apigenin, a modulator of PPARγ, attenuates HFD-induced NAFLD by
   regulating hepatocyte lipid metabolism and oxidative stress via Nrf2
   activation
SO BIOCHEMICAL PHARMACOLOGY
LA English
DT Article
DE Apigenin; NAFLD; Nrf2; PPAR gamma
ID NONALCOHOLIC FATTY LIVER; DIET-INDUCED OBESITY; GENE-EXPRESSION; HEPATIC
   STEATOSIS; RECEPTOR-GAMMA; IN-VITRO; DISEASE; MICE; STEATOHEPATITIS;
   INJURY
AB Lipid metabolic disorders and oxidative stress in the liver are key steps in the progression of nonalcoholic fatty liver disease (NAFLD), which is a major risk factor for the development of metabolic syndrome. To date, no pharmacological treatment for this condition has been approved. Our previous study has found that the food-derived compound apigenin (Api) significantly attenuates obesity induced metabolic syndrome by acting as a peroxisome proliferator-activated receptor gamma modulator (PPARM). Herein, a high fat diet (HFD) induced NAFLD model was used to dig out whether Api had the effect on NAFLD. The results showed that Api had obvious effect in restraining NAFLD progression, including attenuating HFD induced lipid accumulation and oxidative stress in vivo. As a PPARM, although Api did significantly inhibit the expression of PPAR gamma target genes encoding the protein associated with lipid metabolism, it had no obvious activating effect on PPAR gamma. Interestingly, we found that Api promoted Nrf2 into the nucleus, thereby markedly activating Nrf2 to inhibit the lipid metabolism related genes and increase the oxidative stress related genes. Further Nrf2 knockdown/knockout and overexpression experiments showed that Api regulating PPAR gamma target genes was dependent on Nrf2 activation and the activation of Nrf2 counteracted the activation effect of PPAR gamma by Api. Importantly, we also found that Api might bind with Nrf2 via auto dock and ITC assay. Therefore, our results indicate that Api ameliorates NAFLD by a novel regulating mode of Nrf2 and PPAR gamma in inhibiting lipid metabolism and oxidative stress abnormity. (C) 2017 Elsevier Inc. All rights reserved.
C1 [Feng, Xiujing; Yu, Wen; Li, Xinda; Zhou, Feifei; Zhang, Wenlong; Shen, Pingping] Nanjing Univ, State Key Lab Pharmaceut Biotechnol, Model Anim Res Ctr, Nanjing 210023, Jiangsu, Peoples R China.
   [Feng, Xiujing; Yu, Wen; Li, Xinda; Zhou, Feifei; Zhang, Wenlong; Shen, Pingping] Nanjing Univ, MOE Key Lab Model Anim Dis Study, Model Anim Res Ctr, Nanjing 210023, Jiangsu, Peoples R China.
   [Shen, Qi; Li, Jianxin] Nanjing Univ, Sch Chem & Chem Engn, Key Lab Analyt Chem Life Sci, Nanjing 210023, Jiangsu, Peoples R China.
   [Zhang, Can] Nanjing Univ, State Key Lab Pharmaceut Biotechnol, Nanjing 210023, Jiangsu, Peoples R China.
   [Zhang, Can] China Pharmaceut Univ, Ctr Drug Discovery, State Key Lab Nat Med, Nanjing 210009, Peoples R China.
C3 Nanjing University; Nanjing University; Nanjing University; Nanjing
   University; China Pharmaceutical University
RP Shen, PP (corresponding author), Nanjing Univ, State Key Lab Pharmaceut Biotechnol, Model Anim Res Ctr, Nanjing 210023, Jiangsu, Peoples R China.; Zhang, C (corresponding author), Nanjing Univ, State Key Lab Pharmaceut Biotechnol, Nanjing 210023, Jiangsu, Peoples R China.; Zhang, C (corresponding author), China Pharmaceut Univ, Ctr Drug Discovery, State Key Lab Nat Med, Nanjing 210009, Peoples R China.
EM zhangcan@cpu.edu.cn; ppshen@nju.edu.cn
RI Shen, PP/S-1616-2016; li, jianxin/CAF-6178-2022; Zhang,
   Can/JUU-9511-2023; Feng, Xiujing/HII-9555-2022
OI Feng, Xiujing/0000-0002-8887-3302
FU open fund of State Key Laboratory of Pharmaceutical Biotechnology,
   Nanjing University, China [KFGN-201501]; National Natural Science
   Foundation of China [81503082, 81673439, 81473220]; Natural Science
   Foundation of Jiangsu Province of China [BK20150575]; Postdoctoral
   Science Foundation of China [2015M570437]
FX The work was supported by the open fund of State Key Laboratory of
   Pharmaceutical Biotechnology, Nanjing University, China (Grant No.
   KFGN-201501), and the National Natural Science Foundation of China (Nos.
   81503082, 81673439 and 81473220), and the Natural Science Foundation of
   Jiangsu Province of China (No. BK20150575), and Postdoctoral Science
   Foundation of China (No. 2015M570437).
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NR 55
TC 179
Z9 186
U1 7
U2 124
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0006-2952
EI 1873-2968
J9 BIOCHEM PHARMACOL
JI Biochem. Pharmacol.
PD JUL 15
PY 2017
VL 136
BP 136
EP 149
DI 10.1016/j.bcp.2017.04.014
PG 14
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA EX3KB
UT WOS:000403129900013
PM 28414138
DA 2025-06-11
ER

PT J
AU Amos, D
   Cook, C
   Santanam, N
AF Amos, Deborah
   Cook, Carla
   Santanam, Nalini
TI Omega 3 rich diet modulates energy metabolism via GPR120-Nrf2 crosstalk
   in a novel antioxidant mouse model
SO BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
LA English
DT Article
DE Diet-induced obesity; Redox stress; Adipose tissue; Catalase
ID HIGH-FAT DIET; GROWTH-FACTOR 21; ADIPOSE-TISSUE; INSULIN-RESISTANCE;
   OXIDATIVE STRESS; EICOSAPENTAENOIC ACID; REDUCTIVE STRESS; SUBSTRATE
   OXIDATION; KEAP1-NRF2 SYSTEM; INDUCED OBESITY
AB With obesity rates reaching epidemic proportions, more studies concentrated on reducing the risk and treating this epidemic are vital. Redox stress is an important metabolic regulator involved in the pathophysiology of cardiovascular disease, Type 2 diabetes, and obesity. Oxygen and nitrogen-derived free radicals alter glucose and lipid homeostasis in key metabolic tissues, leading to increases in risk of developing metabolic syndrome. Oxidants derived from dietary fat differ in their metabolic regulation, with numerous studies showing benefits from a high omega 3 rich diet compared to the frequently consumed "western diet" rich in saturated fat. Omega 3 (OM3) fatty acids improve lipid profile, lower inflammation, and ameliorate insulin resistance, possibly through maintaining redox homeostasis. This study is based on the hypothesis that altering endogenous antioxidant production and/or increasing OM3 rich diet consumption will improve energy metabolism and maintain insulin sensitivity. We tested the comparative metabolic effects of a diet rich in saturated fat (HFD) and an omega 3-enriched diet (OM3) in the newly developed 'stress-less' mice model that overexpresses the endogenous antioxidant catalase. Eight weeks of dietary intervention showed that mice overexpressing endogenous catalase compared to their wild-type controls when fed an OM3 enriched diet, in contrast to HFD, activated GPR120-Nrf2 cross-talk to maintain balanced energy metabolism, normal circadian rhythm, and insulin sensitivity. These findings suggest that redox regulation of GPR120/FFAR4 might be an important target in reducing risk of metabolic syndrome and associated diseases.
C1 [Amos, Deborah; Cook, Carla; Santanam, Nalini] Marshall Univ, Joan C Edwards Sch Med, Dept Biomed Sci, 1700 3rd Ave,435S BBSC, Huntington, WV 25755 USA.
C3 Marshall University
RP Santanam, N (corresponding author), Marshall Univ, Joan C Edwards Sch Med, Dept Biomed Sci, 1700 3rd Ave,435S BBSC, Huntington, WV 25755 USA.
EM santanam@marshall.edu
OI Santanam, Nalini/0000-0003-3343-6081
FU NIH [5R01HL-074239, 5P20RR016477, 1R15AG051062-01]; WV-NASA Grant
   Consortium
FX The authors acknowledge Dr. Jung Han Kim for her assistance with
   ECHO-MRI and CLAMS studies as well as Logan Efaw, Melissa Massie, Aaron
   Roberts, Jonique George and Sarah Marshall for their assistance with the
   feeding studies, quantitative PCR and Western Blotting. This study was
   partially supported by NIH Grant 5R01HL-074239 (NS), 5P20RR016477 (NS),
   1R15AG051062-01 (NS), and WV-NASA Grant Consortium (DA).
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NR 139
TC 23
Z9 26
U1 0
U2 23
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1388-1981
EI 1879-2618
J9 BBA-MOL CELL BIOL L
JI Biochim. Biophys. Acta Mol. Cell Biol. Lipids
PD APR
PY 2019
VL 1864
IS 4
BP 466
EP 488
DI 10.1016/j.bbalip.2019.01.002
PG 23
WC Biochemistry & Molecular Biology; Biophysics; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Cell Biology
GA HM3IF
UT WOS:000459366300003
PM 30658097
OA Bronze, Green Accepted
DA 2025-06-11
ER

PT J
AU Devaraj, S
   Leonard, S
   Traber, MG
   Jialal, I
AF Devaraj, Sridevi
   Leonard, Scott
   Traber, Maret G.
   Jialal, Ishwarlal
TI γ-tocopherol supplementation alone and in combination with α-tocopherol
   alters biomarkers of oxidative stress and inflammation in subjects with
   metabolic syndrome
SO FREE RADICAL BIOLOGY AND MEDICINE
LA English
DT Article
DE antioxidant; tocopherol; inflammation; oxidative stress; nitrative
   stress
ID C-REACTIVE PROTEIN; VITAMIN-E; PLATELET-AGGREGATION; NITRIC-OXIDE;
   DISEASE; MARKERS; HUMANS
AB Metabolic syndrome (MetS) is associated with increased incidence of diabetes and cardiovascular disease (CVD). Prospective clinical trials with alpha-tocopherol (AT) have not yielded positive results. Because AT supplementation decreases circulating gamma-tocopherol (GT), we evaluated supplementation with GT (800 mg/day), AT (800 mg/day), the combination or placebo for 6 weeks alone AT and GT concentrations, biomarkers of oxidative stress, and inflammation in subjects with MetS (n = 20/group). Plasma AT and GT levels increased following supplementation with AT alone or GT alone or in combination. AT supplementation significantly decreased GT levels. Urinary alpha- and gamma-CEHC, metabolites of the respective Ts, also increased correspondingly, i.e., alpha-CEHC with AT and gamma-CEHC with GT supplementation, compared to placebo. HsCRP levels significantly decreased in the combined AT+GT group. LPS-activated whole blood release of IL-1 and IL-6 did not change. There was a significant decrease in TNF with AT alone or in combination with GT. Plasma MDA/HNE and lipid peroxides were significantly decreased with AT, GT, or in combination. Nitrotyrosine levels were significantly decreased only with GT or GT+AT but not with AT compared to placebo, Thus, the combination of AT and GT supplementation appears to be superior to either supplementation alone on biomarkers of oxidative stress and inflammation and needs to be tested in prospective clinical trials to elucidate its utility in CVD prevention. (C) 2007 Elsevier Inc. All rights reserved.
C1 [Devaraj, Sridevi; Jialal, Ishwarlal] UC Davis Med Ctr, Dept Pathol, Lab Atherosclerosis & Metab Res, Sacramento, CA 95817 USA.
   [Devaraj, Sridevi; Jialal, Ishwarlal] UC Davis Med Ctr, Lab Med, Sacramento, CA 95817 USA.
   [Leonard, Scott; Traber, Maret G.] Oregon State Univ, Linus Pauling Inst, Corvallis, OR 97331 USA.
C3 University of California System; University of California Davis;
   University of California System; University of California Davis; Oregon
   State University
RP Devaraj, S (corresponding author), UC Davis Med Ctr, Dept Pathol, Lab Atherosclerosis & Metab Res, 4635 2 Ave,Res 1 Bldg,Rm 3000, Sacramento, CA 95817 USA.
EM sridevi.devaraj@ucdmc.ucdavis.edu
RI Traber, Maret/ABI-2511-2020; Jialal, Ishwarlal/AAG-6218-2019
OI Leonard, Scott/0000-0001-9967-7078; Traber, Maret/0000-0002-2892-4024
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NR 26
TC 163
Z9 182
U1 1
U2 17
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0891-5849
EI 1873-4596
J9 FREE RADICAL BIO MED
JI Free Radic. Biol. Med.
PD MAR 15
PY 2008
VL 44
IS 6
BP 1203
EP 1208
DI 10.1016/j.freeradbiomed.2007.12.018
PG 6
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 278HH
UT WOS:000254275300027
PM 18191645
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Gersch, C
   Palii, SP
   Imaram, W
   Kim, KM
   Karumanchi, SA
   Angerhofer, A
   Johnson, RJ
   Henderson, GN
AF Gersch, Christine
   Palii, Sergiu P.
   Imaram, Witcha
   Kim, Kyung Mee
   Karumanchi, S. Ananth
   Angerhofer, Alexander
   Johnson, Richard J.
   Henderson, George N.
TI Reactions of Peroxynitrite with Uric Acid: Formation of Reactive
   Intermediates, Alkylated Products and Triuret, and In Vivo Production of
   Triuret Under Conditions of Oxidative Stress
SO NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
LA English
DT Article
DE Uric acid; methyluric acid; peroxynitrite; cardiovascular disease;
   endothelial dysfunction; triuret; ascorbate; alkylation; preeclampsia;
   hypertension; oxidative stress; reactive intermediates
ID FREE-RADICAL FORMATION; NITRIC-OXIDE; BLOOD-PRESSURE; URATE OXIDASE;
   HYPERURICEMIA; ANTIOXIDANT; IDENTIFICATION; INACTIVATION; PATHOGENESIS;
   PROOXIDANT
AB Hyperuricemia is associated with hypertension, metabolic syndrome, preeclampsia, cardio-vascular disease and renal disease, all conditions associated with oxidative stress. We hypothesized that uric acid, a known antioxidant, might become prooxidative following its reaction with oxidants; and, thereby contribute to the pathogenesis of these diseases. Uric acid and 1,3-15N2-uric acid were reacted with peroxynitrite in different buffers and in the presence of alcohols, antioxidants and in human plasma. The reaction products were identified using liquid chromatography-mass spectrometry (LC-MS) analyses. The reactions generate reactive intermediates that yielded triuret as their final product. We also found that the antioxidant, ascorbate, could partially prevent this reaction. Whereas triuret was preferentially generated by the reactions in aqueous buffers, when uric acid or 1,3-15N2-uric acid was reacted with peroxynitrite in the presence of alcohols, it yielded alkylated alcohols as the final product. By extension, this reaction can alkylate other biomolecules containing OH groups and others containing labile hydrogens. Triuret was also found to be elevated in the urine of subjects with preeclampsia, a pregnancy-specific hypertensive syndrome that is associated with oxidative stress, whereas very little triuret is produced in normal healthy volunteers. We conclude that under conditions of oxidative stress, uric acid can form reactive intermediates, including potential alkylating species, by reacting with peroxynitrite. These reactive intermediates could possibly explain how uric acid contributes to the pathogenesis of diseases such as the metabolic syndrome and hypertension.
C1 [Palii, Sergiu P.; Kim, Kyung Mee; Henderson, George N.] Univ Florida, Coll Med, Dept Med, Div Endocrinol & Metab, Gainesville, FL 32610 USA.
   [Imaram, Witcha; Angerhofer, Alexander] Univ Florida, Dept Chem, Coll Liberal Arts & Sci, Gainesville, FL 32610 USA.
   [Karumanchi, S. Ananth] Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Boston, MA USA.
   [Johnson, Richard J.; Henderson, George N.] Univ Florida, Div Nephrol & Hypertens, Dept Med, Gainesville, FL 32610 USA.
   [Henderson, George N.] Univ Florida, Gen Clin Res Ctr, Gainesville, FL 32610 USA.
C3 State University System of Florida; University of Florida; State
   University System of Florida; University of Florida; Harvard University;
   Harvard University Medical Affiliates; Beth Israel Deaconess Medical
   Center; Harvard Medical School; State University System of Florida;
   University of Florida; State University System of Florida; University of
   Florida
RP Henderson, GN (corresponding author), Univ Florida, Hlth Sci Ctr, Div Nephrol, Dept Med, Box 100224, Gainesville, FL 32610 USA.
EM hende3000@yahoo.com
RI ; Angerhofer, Alexander/E-3143-2010
OI Karumanchi, Subbian/0000-0002-2281-6831; Angerhofer,
   Alexander/0000-0002-8580-6024
FU NCRR NIH HHS [M01-RR00082, M01 RR000082] Funding Source: Medline; NHLBI
   NIH HHS [HL-68607, R01 HL068607] Funding Source: Medline; NIDDK NIH HHS
   [R01 DK052121, DK-52121] Funding Source: Medline
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NR 54
TC 79
Z9 89
U1 0
U2 18
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1525-7770
EI 1532-2335
J9 NUCLEOS NUCLEOT NUCL
JI Nucleosides Nucleotides Nucleic Acids
PY 2009
VL 28
IS 2
BP 118
EP 149
AR PII 908701251
DI 10.1080/15257770902736400
PG 32
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 407MQ
UT WOS:000263368800005
PM 19219741
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Hayden, MR
   Tyagi, SC
AF Hayden, MR
   Tyagi, SC
TI Neural redox stress and remodeling in metabolic syndrome, type 2
   diabetes mellitus, and diabetic neuropathy
SO MEDICAL SCIENCE MONITOR
LA English
DT Review
DE atherosclerosis; atheroscleropathy; diabetic neuropathy; polyneuropathy;
   insulin resistance; endothelial nitric oxide synthase - eNOS;
   endothelial nitric oxide - eNO; extracellular matrix; prediabetes;
   oxidative stress; reactive oxygen species
ID NITRIC-OXIDE SYNTHASE; NERVE GROWTH-FACTOR; C-REACTIVE PROTEIN;
   CORONARY-HEART-DISEASE; BLOOD-BRAIN-BARRIER; RENIN-ANGIOTENSIN SYSTEM;
   TO-RETENTION HYPOTHESIS; CARPAL-TUNNEL-SYNDROME; INNATE IMMUNE-SYSTEM;
   COENZYME-A REDUCTASE
AB Diabetic polyneuropathy (DPN) is the most common complication of diabetes and may frequently be the presenting symptom in type 2 diabetes mellitus (T2DM). Metabolic syndrome and T2DM are associated with multiple metabolic toxicities. These substrate toxicities support the formation of reactive oxygen species (ROS), which are so damaging to cells, tissues and organs and play an important role in the development of multiple diabetic complications. The importance of redox stress (ROS) and their effect on the neuronal unit are discussed. There are at least 5 major pathways involved in the development of DPN: metabolic, vascular, immunologic-autoimmune, neurohormonal growth factor deficiency, and extracellular matrix neuronal unit remodeling.
   Each of these five pathways are reviewed and related to neural redox stress and the role of ROS. The identification of the toxic substrates (A-FLIGHT acronym), earlier diagnosis of T2DM at the stage of impaired glucose tolerance or impaired fasting glucose, and aggressive global risk reduction with the use of a simple RAAS acronym will assist the clinician in slowing the natural progressive history, and possibly preventing the complications associated with DPN.
   The pain, foot ulceration, limb loss, organ dysfunction, and the associated morbidity and financial burden all contribute to the need for a better understanding of DPN and the role of redox stress and global risk reduction.
C1 Univ Missouri Columbia, Dept Family & Community Med, Camdenton, MO 65020 USA.
   Univ Louisville, Sch Med, Dept Physiol & Biophys, Louisville, KY 40292 USA.
C3 University of Missouri System; University of Missouri Columbia;
   University of Louisville
RP Univ Missouri Columbia, Dept Family & Community Med, POB 1140 Lk Rd 5-87, Camdenton, MO 65020 USA.
EM mrh29@usmo.com
RI Moody, Michael/H-9377-2013
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NR 182
TC 22
Z9 25
U1 0
U2 7
PU INT SCIENTIFIC INFORMATION, INC
PI MELVILLE
PA 150 BROADHOLLOW RD, STE 114, MELVILLE, NY 11747 USA
SN 1643-3750
J9 MED SCI MONITOR
JI Med. Sci. Monitor
PD DEC
PY 2004
VL 10
IS 12
BP RA291
EP RA307
PG 17
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 880OQ
UT WOS:000225799500022
PM 15567993
DA 2025-06-11
ER

PT J
AU Hauck, AK
   Zhou, T
   Hahn, W
   Petegrosso, R
   Kuang, R
   Chen, Y
   Bernlohr, DA
AF Hauck, Amy K.
   Zhou, Tong
   Hahn, Wendy
   Petegrosso, Raphael
   Kuang, Rui
   Chen, Yue
   Bernlohr, David A.
TI Obesity-induced protein carbonylation in murine adipose tissue regulates
   the DNA-binding domain of nuclear zinc finger proteins
SO JOURNAL OF BIOLOGICAL CHEMISTRY
LA English
DT Article
DE oxidative stress; zinc finger; adipose tissue; nuclear receptor;
   obesity; carbonylation; zinc finger proteins; nucleus; estrogen-related
   receptor; reactive oxygen species; metabolic syndrome; transcription
   factor
ID LARGE GENE LISTS; OXIDATIVE STRESS; ERR-GAMMA; INSULIN-RESISTANCE;
   PROTEOMIC ANALYSIS; METABOLIC SYNDROME; ACID OXIDATION; ALDEHYDES;
   PRODUCT; IDENTIFICATION
AB In obesity-linked insulin resistance, oxidative stress in adipocytes leads to lipid peroxidation and subsequent carbonylation of proteins by diffusible lipid electrophiles. Reduction in oxidative stress attenuates protein carbonylation and insulin resistance, suggesting that lipid modification of proteins may play a role in metabolic disease, but the mechanisms remain incompletely understood. Herein, we show that in vivo, diet-induced obesity in mice surprisingly results in preferential carbonylation of nuclear proteins by 4-hydroxy-trans-2,3-nonenal (4-HNE) or 4-hydroxy-trans-2,3-hexenal (4-HHE). Proteomic and structural analyses revealed that residues in or around the sites of zinc coordination of zinc finger proteins, such as those containing the C2H2 or MATRIN, RING, C3H1, or N4-type DNA-binding domains, are particularly susceptible to carbonylation by lipid aldehydes. These observations strongly suggest that carbonylation functionally disrupts protein secondary structure supported by metal coordination. Analysis of one such target, the nuclear protein estrogen-related receptor (ERR-), showed that ERR- is modified by 4-HHE in the obese state. In vitro carbonylation decreased the DNA-binding capacity of ERR- and correlated with the obesity-linked down-regulation of many key genes promoting mitochondrial bioenergetics. Taken together, these findings reveal a novel mechanistic connection between oxidative stress and metabolic dysfunction arising from carbonylation of nuclear zinc finger proteins, such as the transcriptional regulator ERR-.
C1 [Hauck, Amy K.; Zhou, Tong; Hahn, Wendy; Chen, Yue; Bernlohr, David A.] Univ Minnesota Twin Cities, Dept Biochem Mol Biol & Biophys, Minneapolis, MN 55455 USA.
   [Petegrosso, Raphael; Kuang, Rui] Univ Minnesota Twin Cities, Dept Comp Sci & Engn, Minneapolis, MN 55455 USA.
C3 University of Minnesota System; University of Minnesota Twin Cities;
   University of Minnesota System; University of Minnesota Twin Cities
RP Bernlohr, DA (corresponding author), Univ Minnesota Twin Cities, Dept Biochem Mol Biol & Biophys, Minneapolis, MN 55455 USA.
EM bernl001@umn.edu
FU National Institutes of Health [R01 DK084669, T32 GM008347]; Minnesota
   Agricultural Experiment Station; CAPES Foundation, Ministry of Education
   of Brazil [BEX 13250/13-2]
FX This work was supported by National Institutes of Health Grant R01
   DK084669 and the Minnesota Agricultural Experiment Station (to D.A.B.),
   National Institutes of Health Grant T32 GM008347 (to A.K.H.), and the
   CAPES Foundation, Ministry of Education of Brazil (BEX 13250/13-2) (to
   R.P.). The authors declare that they have no conflicts of interest with
   the contents of this article. The content is solely the responsibility
   of the authors and does not necessarily represent the official views of
   the National Institutes of Health.
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NR 61
TC 17
Z9 20
U1 0
U2 9
PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3996 USA
EI 1083-351X
J9 J BIOL CHEM
JI J. Biol. Chem.
PD AUG 31
PY 2018
VL 293
IS 35
BP 13464
EP 13476
DI 10.1074/jbc.RA118.003469
PG 13
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA GS2JV
UT WOS:000443375500010
PM 30012885
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Kanagasabai, T
   Ardern, CI
AF Kanagasabai, Thirumagal
   Ardern, Chris I.
TI Contribution of Inflammation, Oxidative Stress, and Antioxidants to the
   Relationship between Sleep Duration and Cardiometabolic Health
SO SLEEP
LA English
DT Article
DE antioxidants; cardiometabolic health; indirect mediation effect;
   inflammation and oxidative stress; sleep duration
ID GAMMA-GLUTAMYL-TRANSFERASE; BODY-MASS INDEX; SERUM URIC-ACID; METABOLIC
   SYNDROME; BLOOD-PRESSURE; VITAMIN-C; CARDIOVASCULAR RISK; APNEA
   SYNDROME; US ADULTS; ATHEROSCLEROSIS
AB Objectives: To explore the interrelationship and mediating effect of factors that are beneficial (i.e., antioxidants) and harmful (i.e., inflammation and oxidative stress) to the relationship between sleep and cardiometabolic health.
   Design: Cross-sectional data from the 2005-2006 National Health and Nutrition Examination Survey.
   Setting: Nationally representative population sample from the US.
   Participants: Age >= 20 y with sleep data; final analytical sample of n = 2,079.
   Interventions: N/A.
   Measurements and Results: Metabolic syndrome was classified according to the Joint Interim Statement, and sleep duration was categorized as very short, short, adequate, and long sleepers (<= 4, 5-6, 7-8, and = 9 h per night, respectively). The indirect mediation effect was quantified as large (>= 0.25), moderate (>= 0.09), modest (>= 0.01), and weak (< 0.01). In general, inflammation was above the current clinical reference range across all sleep duration categories, whereas oxidative stress was elevated among short and very short sleepers. Select sleep duration-cardiometabolic health relationships were mediated by C-reactive protein (CRP),gamma-glutamyl transferase (GGT), carotenoids, uric acid, and vitamins C and D, and were moderated by sex. Specifically, moderate-to-large indirect mediation by GGT, carotenoids, uric acid, and vitamin D were found for sleep duration-waist circumference and -systolic blood pressure relationships, whereas vitamin C was a moderate mediator of the sleep duration-diastolic blood pressure relationship.
   Conclusions: Several factors related to inflammation, oxidative stress, and antioxidant status were found to lie on the casual pathway of the sleep duration-cardiometabolic health relationship. Further longitudinal studies are needed to confirm our results.
C1 [Kanagasabai, Thirumagal; Ardern, Chris I.] York Univ, Sch Kinesiol & Hlth Sci, Toronto, ON M3J 1P3, Canada.
C3 York University - Canada
RP Ardern, CI (corresponding author), York Univ, Sch Kinesiol & Hlth Sci, 352 Norman Bethune Coll, Toronto, ON M3J 1P3, Canada.
EM cardern@yorku.ca
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NR 43
TC 62
Z9 69
U1 3
U2 27
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
EI 1550-9109
J9 SLEEP
JI Sleep
PD DEC 1
PY 2015
VL 38
IS 12
BP 1905
EP 1912
DI 10.5665/sleep.5238
PG 8
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA CX3RH
UT WOS:000365616300014
PM 26237775
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Tinkov, AA
   Ajsuvakova, OP
   Skalnaya, MG
   Popova, EV
   Sinitskii, AI
   Nemereshina, ON
   Gatiatulina, ER
   Nikonorov, AA
   Skalny, AV
AF Tinkov, Alexey A.
   Ajsuvakova, Olga P.
   Skalnaya, Margarita G.
   Popova, Elizaveta V.
   Sinitskii, Anton I.
   Nemereshina, Olga N.
   Gatiatulina, Evgenia R.
   Nikonorov, Alexandr A.
   Skalny, Anatoly V.
TI Mercury and metabolic syndrome: a review of experimental and clinical
   observations
SO BIOMETALS
LA English
DT Review
DE Mercury; Toxicity; Obesity; Insulin resistance; Hypertension;
   Dyslipidemia; Atherosclerosis
ID ENDOPLASMIC-RETICULUM STRESS; KOREA NATIONAL-HEALTH; PRENATAL
   METHYLMERCURY EXPOSURE; INCREASED OXIDATIVE STRESS;
   CORONARY-HEART-DISEASE; NF-KAPPA-B; LIPID-PEROXIDATION; IN-VITRO;
   SUPEROXIDE-DISMUTASE; INSULIN-RESISTANCE
AB A significant interrelation between heavy metal exposure and metabolic syndrome (MetS) development has been demonstrated earlier. Despite the presence of a number of works aimed at the investigation of the role of Hg in MetS development, the existing data remain contradictory. Therefore, the primary objective of the current work is to review the existing data regarding the influence of mercury on universal mechanisms involved in the pathogenesis of the development of MetS and its components. The brief chemical characterization of mercury is provided. The role of mercury in induction of oxidative stress has been discussed. In particular, Hg-induced oxidative stress may occur due to both prooxidant action of the metal and decrease in antioxidant enzymes. Despite the absence of direct indications, it can be proposed that mercury may induce endoplasmic reticulum stress. As it is seen from both in vivo and in vitro studies, mercury is capable of inducing inflammation. The reviewed data demonstrate that mercury affects universal pathogenetic mechanisms of MetS development. Moreover, multiple investigations have indicated the role of mercury in pathogenesis of MetS components: dyslipidemia, hypertension, insulin resistance, and obesity to a lesser extent. The present state of data regarding the interrelation between mercury and MetS denotes the following perspectives: (1) Further clinic-epidemiologic and experimental studies are required to estimate the association between mercury exposure and the development of MetS components, especially obesity; (2) Additional investigations of the possible effect of organism's mercury content modulation on MetS pathogenesis should be undertaken.
C1 [Tinkov, Alexey A.; Skalny, Anatoly V.] Yaroslavl State Univ, Lab Biotechnol & Appl Bioelementol, Yaroslavl 150000, Russia.
   [Tinkov, Alexey A.; Popova, Elizaveta V.; Nemereshina, Olga N.; Gatiatulina, Evgenia R.; Nikonorov, Alexandr A.] Orenburg State Med Acad, Dept Biochem, Orenburg 460000, Russia.
   [Ajsuvakova, Olga P.] Orenburg State Agr Univ, Dept Chem, Orenburg 460014, Russia.
   [Ajsuvakova, Olga P.] Orenburg State Pedag Univ, Dept Chem & Methods Chem Teaching, Orenburg 460014, Russia.
   [Skalnaya, Margarita G.; Skalny, Anatoly V.] Russian Soc Trace Elements Med, ANO Ctr Biot Med, Moscow 105064, Russia.
   [Sinitskii, Anton I.] South Ural State Med Univ, Pharmaceut Fac, Dept Chem, Chelyabinsk 453092, Russia.
   [Skalny, Anatoly V.] Orenburg State Univ, Inst Bioelementol, Russian Satellite Ctr Trace Element, Inst UNESCO, Orenburg 460352, Russia.
C3 Yaroslavl State University; Orenburg State Pedagogical University; South
   Ural State Medical University; Orenburg State University
RP Tinkov, AA (corresponding author), Yaroslavl State Univ, Lab Biotechnol & Appl Bioelementol, Sovetskaya St 14, Yaroslavl 150000, Russia.
EM tinkov.a.a@gmail.com
RI Skalny, Anatoly/J-3953-2019; Ajsuvakova, Olga/N-6595-2016; Nikonorova,
   Eugenia/AAQ-5445-2020; Sinitskii, Anton/D-6010-2014; Tinkov,
   Alexey/H-5842-2016; Skalny, Anatolij Viktorovich/F-2906-2015
OI Nikonorov, Alexandr/0000-0001-7214-8176; Skalnaya,
   Margarita/0000-0003-1099-2560; Sinitskii, Anton/0000-0001-5687-3976;
   Tinkov, Alexey/0000-0003-0348-6192; Nemereshina,
   Olga/0000-0001-5399-7498; Nikonorova, Eugenia/0000-0002-6360-2194;
   Popova, Elizabeth/0000-0001-6703-4756; Ajsuvakova,
   Olga/0000-0003-4707-9353; Skalny, Anatolij
   Viktorovich/0000-0002-4185-6783
FU Russian Ministry of Education and Science [2014/258-544]
FX The authors would like to thank Prof. Richard A. Anderson for helpful
   discussions and corrections of the manuscript. The current research is
   supported by Russian Ministry of Education and Science within project
   No. 2014/258-544.
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NR 250
TC 89
Z9 93
U1 1
U2 79
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0966-0844
EI 1572-8773
J9 BIOMETALS
JI Biometals
PD APR
PY 2015
VL 28
IS 2
BP 231
EP 254
DI 10.1007/s10534-015-9823-2
PG 24
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA CE3RE
UT WOS:000351745200001
PM 25633799
DA 2025-06-11
ER

PT J
AU Choi, M
   Park, S
   Lee, M
AF Choi, Munji
   Park, Seongmin
   Lee, Myoungsook
TI L-Carnitine's Effect on the Biomarkers of Metabolic Syndrome: A
   Systematic Review and Meta-Analysis of Randomized Controlled Trials
SO NUTRIENTS
LA English
DT Review
DE L-carnitine; metabolic syndrome; waist circumference; blood pressure;
   fasting blood sugar; triglyceride; HDL-cholesterol
ID INSULIN-RESISTANCE; MAINTENANCE HEMODIALYSIS; OXIDATIVE STRESS; LIPID
   PROFILE; WEIGHT-LOSS; SUPPLEMENTATION; ASSOCIATION; SENSITIVITY; ADULTS;
   WOMEN
AB A systematic review and meta-analysis of randomized controlled trials (RCTs) was carried out to assess L-carnitine supplements' influence on the biomarkers of metabolic syndrome (MetSyn). PubMed, EMBASE, Cochrane library, and CINAHL were used to collect RCT studies published prior to February 2020. RCT studies were included if they had at least one of the following biomarker outcome measurements: waist circumference (WC), blood pressure (BP), fasting blood sugar (FBS), triglyceride (TG), or high density lipoprotein-cholesterol (HDLc). Nine of twenty studies with adequate methodological quality were included in this meta-analysis. The dose of L-carnitine supplementation administered varied between 0.75 and 3 g/day for durations of 8-24 weeks. L-carnitine supplementation significantly reduced WC and systolic BP (SBP), with no significant effects on FBS, TG, and HDLc. We found that L-carnitine supplementation at a dose of more than 1 g/d significantly reduced FBS and TG and increased HDLc. In conclusion, L-carnitine supplementation is correlated with a significant reduction of WC and BP. A dose of 1-3 g/d could improve the biomarkers of MetSyn by reducing FBS and TG and increasing HDLc.
C1 [Choi, Munji; Park, Seongmin; Lee, Myoungsook] Sungshin Womens Univ, Dept Food & Nutr, Seoul 01133, South Korea.
   [Choi, Munji; Park, Seongmin; Lee, Myoungsook] Sungshin Womens Univ, Res Inst Obes Sci, Seoul 01133, South Korea.
   [Park, Seongmin] Gyeongin Reg Korea Food & Drug Adm, Ctr Food & Drug Anal, Incheon 402835, South Korea.
C3 Sungshin Women's University; Sungshin Women's University
RP Lee, M (corresponding author), Sungshin Womens Univ, Dept Food & Nutr, Seoul 01133, South Korea.; Lee, M (corresponding author), Sungshin Womens Univ, Res Inst Obes Sci, Seoul 01133, South Korea.
EM mjchoi@nfsi.or.kr; kpsm3003@korea.kr; mlee@sungshin.ac.kr
OI Lee, Myoungsook/0000-0003-1344-6979
FU National Research Foundation of Korea (NRF) - Korea Government (MSIP)
   [2019R1A2C1008434]
FX This work was supported by the National Research Foundation of Korea
   (NRF) grant funded by the Korea Government (MSIP; 2019R1A2C1008434).
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NR 36
TC 12
Z9 12
U1 1
U2 11
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD SEP
PY 2020
VL 12
IS 9
AR 2795
DI 10.3390/nu12092795
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA OH3FF
UT WOS:000582453200001
PM 32932644
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Pla-Pagà, L
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AF Pla-Paga, Laura
   Guirro, Maria
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   Gibert-Ramos, Albert
   Foguet-Romero, Elisabet
   Catalan, Ursula
   Mayneris-Perxachs, Jordi
   Canela, Nuria
   Valls, Rosa M.
   Arola, Lluis
   Sola, Rosa
   Pedret, Anna
TI Proteomic Analysis of Heart and Kidney Tissues in Healthy and Metabolic
   Syndrome Rats after Hesperidin Supplementation
SO MOLECULAR NUTRITION & FOOD RESEARCH
LA English
DT Article
DE hesperidin; kidneys; metabolic syndrome; proteomics
ID BLOOD-PRESSURE; EXPRESSION; DISEASE; PROTEIN; STRESS; FAMILY; CELLS;
   CD2AP; MICE
AB Scope Proteomics has provided new strategies to elucidate the mechanistic action of hesperidin, a flavonoid present in citrus fruits. Thus, the aim of the present study is to determine the effects of hesperidin supplementation (HS) on the proteomic profiles of heart and kidney tissue samples from healthy and metabolic syndrome (MS) rats.
   Methods and results 24 Sprague Dawley rats are randomized into four groups: healthy rats fed with a standard diet without HS, healthy rats administered with HS (100 mg kg(-1) day(-1)), MS rats without HS, and MS rats administered with HS (100 mg kg(-1) day(-1)) for eight weeks. Heart and kidney samples are obtained, and proteomic analysis is performed by mass spectrometry. Multivariate, univariate, and ingenuity pathways analyses are performed. Comparative and semiquantitative proteomic analyses of heart and kidney tissues reveal differential protein expression between MS rats with and without HS. The top diseases and functions implicated are related to the cardiovascular system, free radical scavenging, lipid metabolism, glucose metabolism, and renal and urological diseases.
   Conclusion This study is the first to demonstrate the protective capacity of hesperidin to change to the proteomic profiles in relation to different cardiovascular risk biomarkers in the heart and kidney tissues of MS rats.
C1 [Pla-Paga, Laura; Valls, Rosa M.; Arola, Lluis; Sola, Rosa; Pedret, Anna] Eurecat, Ctr Tecnol Catalunya, Unitat Nutr & Salut, Av Univ 1, Reus 43204, Spain.
   [Pla-Paga, Laura; Catalan, Ursula; Valls, Rosa M.; Sola, Rosa; Pedret, Anna] Univ Rovira & Virgili, Fac Med & Ciencies Salut Funct Nutr, Oxidat & Cardiovasc Dis Grp NFOC SALUT, C St Llorenc 21, Reus 43201, Spain.
   [Guirro, Maria; Gual-Grau, Andreu; Gibert-Ramos, Albert; Arola, Lluis] Univ Rovira & Virgili, Dept Biochem & Biotechnol, Nutrigen Res Grp, C Marcelli Domingo 1, Tarragona 43007, Spain.
   [Guirro, Maria; Foguet-Romero, Elisabet; Mayneris-Perxachs, Jordi] Univ Rovira & Virgili, EURECAT Ctr Tecnol Catalunya Unique Sci & Tech In, Joint Unit, Ctr Omic Sci, Av Univ 1, Reus 43204, Spain.
   [Catalan, Ursula; Canela, Nuria] Inst Invest Sanitaria Pere Virgili, Av Univ 1, Reus 43204, Spain.
   [Sola, Rosa] Hosp Univ ST Joan, Av Doctor Josep Laporte 2, Reus 43204, Spain.
C3 Universitat Rovira i Virgili; Universitat Rovira i Virgili; Universitat
   Rovira i Virgili; Universitat Rovira i Virgili; Institut d'Investigacio
   Sanitaria Pere Virgili (IISPV)
RP Valls, RM (corresponding author), Univ Rovira & Virgili, Fac Med & Ciencies Salut Funct Nutr, Oxidat & Cardiovasc Dis Grp NFOC SALUT, C St Llorenc 21, Reus 43201, Spain.; Mayneris-Perxachs, J (corresponding author), Univ Rovira & Virgili, EURECAT Ctr Tecnol Catalunya Unique Sci & Tech In, Joint Unit, Ctr Omic Sci, Av Univ 1, Reus 43204, Spain.
EM jmayneris@idibgi.org; rosamaria.valls@urv.cat
RI SOLÀ, Rosa/N-5919-2014; Valls, Rosa/AAB-1163-2019; Mayneris-Perxachs,
   Jordi/AAG-7724-2020; Pla, Laura/Z-6252-2019; Canela, Núria/I-5401-2015;
   Arola, Lluis/C-6074-2011; MAYNERIS-PERXACHS, JORDI/B-2589-2018; Catalan,
   Ursula/N-5712-2014; Gibert Ramos, Albert/F-4438-2017
OI Valls, Rosa Maria/0000-0002-3351-0942; Gual-Grau,
   Andreu/0000-0002-8901-3582; PLA PAGA, LAURA/0000-0003-3033-6691; Arola,
   Lluis/0000-0003-2767-1974; MAYNERIS-PERXACHS, JORDI/0000-0003-3788-3815;
   Catalan, Ursula/0000-0001-8884-9823; Gibert Ramos,
   Albert/0000-0002-5987-1164
FU 7th Framework Program of the European Union; Agency for Business
   Competitiveness of the Government of Catalonia (ACCI) under the
   TECNOspring program [TECSPR14-2-0001]; Estrategic de Recerca i Innovacio
   en Salut postdoctoral grant (Catalunya, Spain) [SLT0021/16/00239]
FX L.A., R.S., and A.P. contributed equally to this work. This research was
   co-funded by the 7th Framework Program of the European Union and the
   Agency for Business Competitiveness of the Government of Catalonia
   (ACCI) under the TECNOspring program awarded to JM-P (TECSPR14-2-0001).
   A.P. has a Torres Quevedo contract (Subprograma Estatal de
   Incorporacion, Plan Estatal de Investigacion Cientifica y Tecnica y de
   Innovacion). U.C. has a Pla Estrategic de Recerca i Innovacio en Salut
   postdoctoral grant (SLT0021/16/00239); Catalunya, Spain).
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NR 51
TC 7
Z9 7
U1 1
U2 29
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1613-4125
EI 1613-4133
J9 MOL NUTR FOOD RES
JI Mol. Nutr. Food Res.
PD MAY
PY 2020
VL 64
IS 10
AR 1901063
DI 10.1002/mnfr.201901063
EA MAY 2020
PG 12
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA LT1QK
UT WOS:000530567900001
PM 32281714
DA 2025-06-11
ER

PT J
AU Barnes, TRE
   Paton, C
   Cavanagh, MR
   Hancock, E
   Taylor, DM
AF Barnes, Thomas R. E.
   Paton, Carol
   Cavanagh, Mary-Rose
   Hancock, Elizabeth
   Taylor, David M.
CA UK Prescribing Observ Mental Hlth
TI A UK audit of screening for the metabolic side effects of antipsychotics
   in community patients
SO SCHIZOPHRENIA BULLETIN
LA English
DT Article
DE metabolic syndrome; obesity; diabetes; dyslipidemia; hypertension;
   psychosis
ID ATYPICAL ANTIPSYCHOTICS; DIABETES-MELLITUS; TREATED PATIENTS;
   WEIGHT-GAIN; SCHIZOPHRENIA; GLUCOSE; PREVALENCE; OBESITY; DISORDERS;
   CONSENSUS
AB Reviews of the association between psychotic disorder, the metabolic syndrome, diabetes, and antipsychotic drugs conclude that there is a need for active, routine physical health screening of patients' prescribed antipsychotic drugs. From published guidelines, we derived the audit standard that all such patients should, as a minimum, have their blood pressure, body mass index (BMI) (or other measure of obesity such as waist circumference), blood glucose (or HbA(1c)), and plasma lipids measured at least once a year. We conducted an audit of the clinical records of 1966 eligible patients under the care of 48 multidisciplinary, assertive outreach clinical teams in 21 mental health services across the United Kingdom. This revealed a recorded measurement within the previous year for blood pressure in 26% of the patients, obesity in 17%, blood glucose (or HbA(1c)) in 28% and plasma lipids in 22%, with all 4 measures documented in 11%. In the total national sample, 6% had a documented diagnosis of diabetes, 6% hypertension, and 6% dyslipidemia. Extrapolating from the prevalence of these disorders in similar populations suggests that for every patient with a known diagnosis of diabetes, another had not been recognized, for every known case of hypertension, 4 had been missed, and for every known case of dyslipidemia, 7 had been missed. The responses of the clinical teams to a questionnaire yielded information on obstacles to screening in routine practice, revealing uncertainty about whose responsibility this was, a lack of confidence about the interpretation of abnormal screening results, and limited access to basic equipment.
C1 Univ London Imperial Coll Sci Technol & Med, Fac Med, Dept Psychol Med, Div Neurosci & Mental Hlth, London W6 8RP, England.
   Royal Coll Psychiatrists, Ctr Qual Improvement, Prescribing Observ Mental Hlth, London E1 8AA, England.
   Maudsley Hosp & Inst Psychiat, S London & Maudsley NHS Trust, London SE5 8AZ, England.
C3 Imperial College London; South London & Maudsley NHS Trust; Maudsley
   Hospital; University of London; King's College London
RP Barnes, TRE (corresponding author), Univ London Imperial Coll Sci Technol & Med, Fac Med, Dept Psychol Med, Div Neurosci & Mental Hlth, Charing Cross Campus,Reynolds Bldg,St Dunstans Rd, London W6 8RP, England.
EM t.r.barnes@imperial.ac.uk
RI Barnes, Thomas/KJC-1245-2024
OI Taylor, David/0000-0002-2557-1710
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NR 41
TC 120
Z9 124
U1 0
U2 21
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0586-7614
EI 1745-1701
J9 SCHIZOPHRENIA BULL
JI Schizophr. Bull.
PD NOV
PY 2007
VL 33
IS 6
BP 1397
EP 1403
DI 10.1093/schbul/sbm038
PG 7
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 227VR
UT WOS:000250686400020
PM 17483101
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Fujii, M
   Kakimoto, M
   Sato, I
   Honma, K
   Kirihara, S
   Nakayama, H
   Fukuoka, T
   Hirohata, S
   Kitamori, K
   Ran, S
   Yamamoto, S
   Watanabe, S
AF Fujii, Moe
   Kakimoto, Mai
   Sato, Ikumi
   Honma, Koki
   Kirihara, Sora
   Nakayama, Hinako
   Fukuoka, Taketo
   Hirohata, Satoshi
   Kitamori, Kazuya
   Ran, Shang
   Yamamoto, Shusei
   Watanabe, Shogo
TI Uric Acid Elevation by Fructose Overload Exacerbates Nash and
   Atherosclerosis via Oxidative Stress
SO CURRENT NUTRITION & FOOD SCIENCE
LA English
DT Article
DE Atherosclerosis; fructose; nonalcoholic steatohepatitis (NASH);
   oxidative stress; stroke-prone spontaneously hypertensive rat 5
   (SHRSP5); uric acid
ID FATTY LIVER-DISEASE; INSULIN-RESISTANCE; NONALCOHOLIC STEATOHEPATITIS;
   FIBROTIC STEATOHEPATITIS; DIETARY FRUCTOSE; NITRIC-OXIDE; HYPERURICEMIA;
   SHRSP5/DMCR; SERUM; RAT
AB Background: Nonalcoholic steatohepatitis (NASH) is well associated with an increased risk of cardiovascular disease (CVD), regardless of risk factors for metabolic syndrome. However, intermediary factors between NASH and CVD remain unknown. In recent years, hyperuricemia has been associated not only with gout but also with several other organ diseases, such as hypertension, chronic renal failure, and metabolic syndrome. In addition, hyperuricemia was shown to frequently occur in patients with NASH and could be a risk factor for CVD. Furthermore, serum uric acid (UA) levels have been linked with fructose intake.Objectives: We hypothesized that fructose loading elevates UA levels and exacerbates NASH and atherosclerosis via oxidative stress.Methods: Stroke-prone spontaneously hypertensive rats (SHRSP5/Dmcr), between 14 to 24 weeks of age, were divided into two groups and fed a high-fat and high-cholesterol (HFC) diet. In addition to the HFC diet, the fructose group was subjected to 10% fructose loading. The oral glucose tolerance test (OGTT) and insulin tolerance test (ITT) were performed at 25-week-old, followed by blood sampling, animal sacrifice, endothelial function test, blood biochemistry, histopathological staining, xanthine oxidase activity test, and genetic analysis performed at 26-week-old.Results: Fructose loading increased UA and oxidative stress levels. In addition, fructose loading induced insulin resistance. The fructose group exhibited aggravated hepatic fibrosis and lipid deposition, as well as enhanced lipid accumulation in the mesenteric arteries.Conclusion: In the SHRSP5/Dmcr rat model, elevated UA levels were a risk factor for the exacerbation of NASH and atherosclerosis via oxidative stress.
C1 [Fujii, Moe; Kakimoto, Mai; Sato, Ikumi; Honma, Koki; Kirihara, Sora; Nakayama, Hinako; Yamamoto, Shusei] Okayama Univ, Dept Med Technol, Grad Sch Hlth Sci, Kita Ku, 2-5-1 Shikata Cho,Kita Ku, Okayama, Okayama 7008558, Japan.
   [Fukuoka, Taketo] Okayama Univ, Fac Hlth Sci, Dept Med Technol, 2-5-1 Shikata Cho,Kita Ku, Okayama, Okayama 7008558, Japan.
   [Hirohata, Satoshi; Yamamoto, Shusei; Watanabe, Shogo] Okayama Univ, Acad Field Hlth Sci, 2-5-1 Shikata Cho,Kita Ku, Okayama, Okayama 7008558, Japan.
   [Kitamori, Kazuya] Kinjo Gakuin Univ, Collage Human Life & Environm, 2-1723 Omori,Moriyama Ku, Nagoya, Aichi 4638521, Japan.
   [Ran, Shang] HeiLongjiang Prov Ctr Dis Control & Prevent, Harbin 150030, Peoples R China.
C3 Okayama University; Okayama University; Okayama University
RP Watanabe, S (corresponding author), Okayama Univ, Acad Field Hlth Sci, 2-5-1 Shikata Cho,Kita Ku, Okayama, Okayama 7008558, Japan.
EM watanabe1224@okayama-u.ac.jp
RI Hirohata, Satoshi/M-5250-2019
OI Yamamoto, Shusei/0009-0004-0582-2879
FU Japan Society for the Promotion [15K19178, 18K10993]; Gout Research
   Foundation of Japan [20H00548, 23K16796]; Grants-in-Aid for Scientific
   Research [20H00548] Funding Source: KAKEN
FX This work was supported by grants from the Japan Society for the
   Promotion of Grant Number 15K19178 and Grant-in-Aid for Scientific
   Research (C), Grant Number 18K10993, and Gout Research Foundation of
   Japan to S.Watanabe Grant Number 20H00548, 23K16796.
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NR 52
TC 1
Z9 1
U1 1
U2 1
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1573-4013
EI 2212-3881
J9 CURR NUTR FOOD SCI
JI Curr. Nutr. Food Sci.
PY 2024
VL 20
IS 2
BP 250
EP 261
DI 10.2174/1573401319666230508150159
PG 12
WC Nutrition & Dietetics
WE Emerging Sources Citation Index (ESCI)
SC Nutrition & Dietetics
GA EL4H7
UT WOS:001139063400003
DA 2025-06-11
ER

PT J
AU Lilao-Garzón, J
   Brito-Casillas, Y
   Quesada-Canales, O
   Wägner, AM
   Muñoz-Descalzo, S
AF Lilao-Garzon, Joaquin
   Brito-Casillas, Yeray
   Quesada-Canales, Oscar
   Waegner, Ana M.
   Munoz-Descalzo, Silvia
TI Maternal age, obesity and hyperglycaemia are associated with a delay in
   preimplantation embryo development in mouse
SO REPRODUCTION
LA English
DT Article
ID DIABETES-MELLITUS; OXIDATIVE STRESS; GLUCOSE; METABOLISM; LESIONS;
   MODELS; HEALTH; TIME; ACID; RAT
AB Delayed maternal age, obesity and diabetes are associated with reduced fertility. We investigated how age and obesity/metabolic syndrome impact fertility and hypothesized that its decrease is due to defects in preimplantation embryo development. Three groups of female C57Bl6 mice (12 weeks, 9 months and 1 year old) were fed either a high-fat diet for 8 weeks, to induce obesity and the metabolic syndrome, or a control chow diet. Body weight and composition, glucose tolerance and insulin resistance were assessed. Fecundity was evaluated by mating and pregnancy rates, as well as by the number of embryos. Embryo quality was assessed morphologically, and cell fate composition was analysed in preimplantation embryos by state-of-the-art single-cell quantitative confocal image analysis. The high-fat diet was associated with increased adiposity, glucose intolerance and insulin resistance, especially in the older mice. Fecundity was affected by age more than by the diet. Both age and high-fat diet were associated with reduced cell fate allocation, indicating a delay in the preimplantation embryo development, and with increased expression of GATA3, an inhibitor of placentation. These results support that age and the metabolic syndrome reduce fertility through mechanisms which are present at conception or very early in pregnancy.
C1 [Lilao-Garzon, Joaquin; Brito-Casillas, Yeray; Waegner, Ana M.; Munoz-Descalzo, Silvia] ULPGC, IUIBS, Las Palmas Gran Canaria, Spain.
   [Quesada-Canales, Oscar] Univ Las Palmas Gran Canaria, Inst Anim Hlth, Sch Vet, Vet Histol & Pathol, Las Palmas Gran Canaria, Spain.
   [Waegner, Ana M.] Complejo Hosp Univ Insular Materno Infantil Gran, Serv Endocrinol & Nutr, Las Palmas Gran Canaria, Spain.
C3 Universidad de Las Palmas de Gran Canaria; Universidad de Las Palmas de
   Gran Canaria
RP Wägner, AM; Muñoz-Descalzo, S (corresponding author), ULPGC, IUIBS, Las Palmas Gran Canaria, Spain.; Wägner, AM (corresponding author), Complejo Hosp Univ Insular Materno Infantil Gran, Serv Endocrinol & Nutr, Las Palmas Gran Canaria, Spain.
RI Wägner, Ana/AAS-9601-2021; Quesada-Canales, Oscar/JZE-4935-2024;
   Munoz-Descalzo, Silvia/M-8094-2013; Brito Casillas, Yeray/U-6954-2018
OI Wagner, Ana M/0000-0002-7663-9308; Lilao-Garzon,
   Joaquin/0000-0002-9971-2459; Munoz-Descalzo, Silvia/0000-0003-0939-7721;
   Quesada-Canales, Oscar/0000-0002-2365-351X; Brito Casillas,
   Yeray/0000-0002-0707-7444
FU SMD lab by the ACIISI [CEI2019-02]; Programa de Ayudas a la
   Investigacion de la ULPGC; FEDER Funds [ProID2020010013]; Instituto de
   Salud Carlos III [PI16/00587, PI20/00846, PMP21/00069]; ACIISI
   [ProID2021010143]; European Regional Development Funds; European Horizon
   2020 Programme [101017385]; Fundacion Canaria del Instituto de
   Investigaciones Sanitarias de Canarias [PI19/30, PIFIISC20/16]; ULPGC
   pre-doctoral program
FX This work was supported at SMD lab by the ACIISI (CEI2019-02), Programa
   de Ayudas a la Investigacion de la ULPGC and ACIISI co-funded by FEDER
   Funds (ProID2020010013). Also at AMW lab by Instituto de Salud Carlos
   III (PI16/00587, PI20/00846, PMP21/00069) and ACIISI (ProID2021010143)
   co-funded by European Regional Development Funds, as well as the
   European Horizon 2020 Programme (101017385) and Fundacion Canaria del
   Instituto de Investigaciones Sanitarias de Canarias (PI19/30,
   PIFIISC20/16). JLG is supported by the ULPGC pre-doctoral program. SMD
   by the 'Viera y Clavijo' Program from the Agencia Canaria de
   Investigacion, Innovacion y Sociedad de la Informacion (ACIISI) and the
   ULPGC.
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NR 54
TC 3
Z9 3
U1 1
U2 4
PU BIOSCIENTIFICA LTD
PI BRISTOL
PA STARLING HOUSE, 1600 BRISTOL PARKWAY N, BRISTOL, ENGLAND
SN 1470-1626
EI 1741-7899
J9 REPRODUCTION
JI Reproduction
PD SEP 1
PY 2023
VL 166
IS 3
BP 235
EP 245
DI 10.1530/REP-23-0024
PG 11
WC Developmental Biology; Reproductive Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Developmental Biology; Reproductive Biology
GA ML6B8
UT WOS:001193805100001
PM 37889771
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Santana, AIC
   das Merces, MC
   de Souza, MC
   Lima, BGD
   Galdino, MJQ
   Félix, NDD
   Magalhaes, LBNC
   Coelho, JMF
   Barbosa, PJB
   Gomes, EVD
   Pimentel, RFW
   de Sousa, AR
   de Oliveira, MAF
   de Queiroz, AM
   Florencio, RMS
   Neto, JLC
   Gomes, AMT
   Santos, TBS
   Vieira, SL
   de Sousa, DG
   de Andrade, PCDT
   Maduro, IPDN
   Fernandes, SL
   Damasceno, KSM
   da Silva, DAR
   D'Oliveira, A Jr
AF Costa Santana, Amalia Ivine
   das Merces, Magno Conceicao
   de Souza, Marcio Costa
   de Carvalho Lima, Bruno Gil
   Quina Galdino, Maria Jose
   de Carvalho Felix, Nuno Damacio
   Neves Cunha Magalhaes, Lucelia Batista
   Freitas Coelho, Julita Maria
   Bastos Barbosa, Paulo Jose
   Dias Gomes, Erica Velasco
   Weyll Pimentel, Rodrigo Fernandes
   de Sousa, Anderson Reis
   Ferreira de Oliveira, Marcia Aparecida
   de Queiroz, Aline Macedo
   Silva Florencio, Raissa Millena
   Cavalcante Neto, Jorge Lopes
   Tosoli Gomes, Antonio Marcos
   Souza Santos, Thadeu Borges
   Vieira, Silvana Lima
   de Sousa, Danilo Guimaraes
   da Silva Thiengo de Andrade, Priscila Cristina
   de Negreiros Nogueira Maduro, Isolda Prado
   Fernandes, Sandra Lucia
   Meneses Damasceno, Kairo Silvestre
   Reis da Silva, Dandara Almeida
   D'Oliveira Junior, Argemiro
TI Interaction between Work and Metabolic Syndrome: A Population-Based
   Cross-Sectional Study
SO HEALTHCARE
LA English
DT Article
DE epidemiological studies; metabolic syndrome; professional burnout;
   worker's health; primary health care
ID LIFE-STYLE; PREVALENCE; BURNOUT; STRESS
AB Metabolic syndrome (MS) is a clinical condition and a relevant risk factor in the development of cardiovascular diseases; it occurs as a result of lifestyle factors, e.g., work. The aim of this research was to estimate the interaction between work and MS among primary health care (PHC) nursing professionals in the state of Bahia, Brazil. A sectional multicentered study carried out in 43 municipalities in Bahia, whose study population consisted of nursing professionals. The exposure variables were occupation, professional exhaustion, and working time, and the outcome variable was MS. Interaction measures based on the additivity criteria were verified by calculating the excess risks due to the interactions and according to the proportion of cases attributed to the interactions and the synergy index. The global MS prevalence is 24.4%. There was a greater magnitude in the exposure group regarding the three investigated factors (average level occupation, professional exhaustion, and working time in PHC for more than 5 years), reaching an occurrence of 44.9% when compared to the prevalence of 13.1% in the non-exposure group (academic education, without professional burnout, and working time in PHC for up to 5 years). The study's findings showed a synergistic interaction of work aspects for MS occurrence among PHC nursing professionals.
C1 [Costa Santana, Amalia Ivine; das Merces, Magno Conceicao; Weyll Pimentel, Rodrigo Fernandes; Meneses Damasceno, Kairo Silvestre; D'Oliveira Junior, Argemiro] Fed Univ Bahia UFBA, Sch Med, Hlth Sci Postgrad Program, BR-40026010 Salvador, BA, Brazil.
   [das Merces, Magno Conceicao; de Souza, Marcio Costa; Freitas Coelho, Julita Maria; Bastos Barbosa, Paulo Jose; Dias Gomes, Erica Velasco; Weyll Pimentel, Rodrigo Fernandes; Cavalcante Neto, Jorge Lopes; Souza Santos, Thadeu Borges; Vieira, Silvana Lima; de Sousa, Danilo Guimaraes; Meneses Damasceno, Kairo Silvestre; Reis da Silva, Dandara Almeida] State Univ Bahia UNEB, Dept Life Sci, BR-41150000 Salvador, BA, Brazil.
   [das Merces, Magno Conceicao; de Carvalho Lima, Bruno Gil; Neves Cunha Magalhaes, Lucelia Batista] Fed Univ Bahia UFBA, FTC Univ Ctr UniFTC, BR-41741590 Salvador, BA, Brazil.
   [de Carvalho Lima, Bruno Gil] Fed Univ Bahia UFBA, Sch Med, Dept Pathol & Forens Med, BR-40026010 Salvador, BA, Brazil.
   [Quina Galdino, Maria Jose] State Univ Northern Parana UENP, Dept Nursing, BR-86360000 Bandeirantes, Parana, Brazil.
   [de Carvalho Felix, Nuno Damacio] Fed Univ Reconcavo Bahia UFRB, Hlth Sci Ctr, BR-44574490 Santo Antonio De Jesus, BA, Brazil.
   [Neves Cunha Magalhaes, Lucelia Batista] Fed Univ Bahia UFBA, Sch Med, Dept Family Hlth, BR-40026010 Salvador, BA, Brazil.
   [Weyll Pimentel, Rodrigo Fernandes; de Negreiros Nogueira Maduro, Isolda Prado; Fernandes, Sandra Lucia] Brazilian Assoc Nutr ABRAN, BR-15801150 Catanduva, SP, Brazil.
   [de Sousa, Anderson Reis] Fed Univ Bahia UFBA, Sch Nursing, BR-40231300 Salvador, BA, Brazil.
   [Ferreira de Oliveira, Marcia Aparecida] Univ Sao Paulo, Sch Nursing, Dept Maternal Child & Psychiat Nursing, BR-05403000 Sao Paulo, SP, Brazil.
   [de Queiroz, Aline Macedo; Silva Florencio, Raissa Millena] Fed Univ UFPA, Sch Nursing, BR-66075110 Belem, Para, Brazil.
   [Tosoli Gomes, Antonio Marcos; da Silva Thiengo de Andrade, Priscila Cristina] State Univ Rio de Janeiro UERJ, Sch Nursing, BR-20551030 Rio De Janeiro, Brazil.
   [de Negreiros Nogueira Maduro, Isolda Prado] State Univ Amazonas UEA, Dept Clin Nutr, BR-69850000 Manaus, Amazonas, Brazil.
C3 Universidade do Estado Bahia; Universidade Estadual do Norte do Parana
   (UENP); Universidade de Sao Paulo; Universidade Federal do Para;
   Universidade do Estado do Rio de Janeiro; Universidade do Estado do
   Amazonas
RP das Merces, MC (corresponding author), Fed Univ Bahia UFBA, Sch Med, Hlth Sci Postgrad Program, BR-40026010 Salvador, BA, Brazil.; das Merces, MC (corresponding author), State Univ Bahia UNEB, Dept Life Sci, BR-41150000 Salvador, BA, Brazil.; das Merces, MC (corresponding author), Fed Univ Bahia UFBA, FTC Univ Ctr UniFTC, BR-41741590 Salvador, BA, Brazil.
EM amalia0807@gmail.com; mmerces@uneb.br; mcsouza@uneb.br;
   brunogil@doctor.com; mariagaldino@uenp.edu.br; nunofelix@ufrb.edu.br;
   luceliamagalhaes@terra.com.br; julitamaria@gmail.com; pjbarbosa@uneb.br;
   enfa.ericavelasco@gmail.com; rodrigo.pimentel@ebserh.gov.br;
   anderson.sousa@ufba.br; marciaap@usp.br; alinemacedo@ufpa.br;
   raissaflorencio@yahoo.com.br; jlcavalcante@uneb.br; mtosoli@gmail.com;
   tbssantos@uneb.br; slvieira@uneb.br; danilogs26@gmail.com;
   profprithiengo@gmail.com; isoldaprado@yahoo.com.br;
   sandranut@yahoo.com.br; kairodamasceno@hotmail.com; darsilva@uneb.br;
   argemiro@ufba.br
RI Cavalcante Neto, Jorge/R-9699-2016; MAGALHÃES, LUCELIA/AAA-1378-2019;
   gomes, erica/IAM-1895-2023; Gomes, A./Q-6844-2016; Vieira,
   Silvana/IZP-6746-2023; Carvalho Félix, Nuno Damácio de/V-6536-2019;
   Merces, Magno/S-6649-2017; GALDINO, MARIA/K-4754-2019; de Sousa,
   Anderson/AAU-7163-2021; Silva Thiengo de Andrade, Priscila
   Cristina/AAE-8949-2022; Florencio, Raissa/KIA-3373-2024; Costa de Souza,
   Marcio/Y-8859-2018; Ferreira de Oliveira, Marcia Aparecida/E-6272-2012
OI Silva Thiengo de Andrade, Priscila Cristina/0000-0003-0840-4838; VELASCO
   DIAS GOMES, ERICA/0000-0003-0643-4355; Florencio,
   Raissa/0000-0002-5085-830X; Galdino, Maria Jose
   Quina/0000-0001-6709-3502; Pimentel, Rodrigo Fernandes
   Weyll/0000-0003-0101-0190; REIS DE SOUSA, ANDERSON/0000-0001-8534-1960;
   Lima, Bruno/0000-0002-1200-4629; Silvestre Meneses Damasceno,
   Kairo/0000-0002-2444-4496; de Carvalho Felix, Nuno
   Damacio/0000-0002-0102-3023; Costa de Souza, Marcio/0000-0002-4922-6786;
   Ferreira de Oliveira, Marcia Aparecida/0000-0002-1069-8700; Coelho,
   Julita/0000-0002-9520-5177; Merces, Magno Conceicao
   das/0000-0003-3493-8606
FU National Council for Scientific and Technological Development (CNPq),
   Brazil [408390/2016-6]
FX Financial support from the National Council for Scientific and
   Technological Development (CNPq), Brazil, Universal Call Notice-protocol
   #408390/2016-6.
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NR 39
TC 1
Z9 1
U1 0
U2 4
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2227-9032
J9 HEALTHCARE-BASEL
JI Healthcare
PD MAR
PY 2022
VL 10
IS 3
AR 544
DI 10.3390/healthcare10030544
PG 12
WC Health Care Sciences & Services; Health Policy & Services
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services
GA 0C3TL
UT WOS:000775239600001
PM 35327022
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Sun, DQ
   Wu, SJ
   Liu, WY
   Lu, QD
   Zhu, GQ
   Shi, KQ
   Braddock, M
   Song, D
   Zheng, MH
AF Sun, Dan-Qin
   Wu, Sheng-Jie
   Liu, Wen-Yue
   Lu, Qian-Di
   Zhu, Gui-Qi
   Shi, Ke-Qing
   Braddock, Martin
   Song, Dan
   Zheng, Ming-Hua
TI Serum uric acid: a new therapeutic target for nonalcoholic fatty liver
   disease
SO EXPERT OPINION ON THERAPEUTIC TARGETS
LA English
DT Review
DE metabolic syndrome; insulin resistance; inflammasomes; therapeutic
   options; nonalcoholic fatty liver disease; serum uric acid
ID METABOLIC SYNDROME; NLRP3 INFLAMMASOME; INSULIN-RESISTANCE;
   CARDIOVASCULAR RISK; LIPID-ACCUMULATION; OXIDATIVE STRESS; CHINESE
   ADULTS; GLUCOSE-UPTAKE; HYPERURICEMIA; ASSOCIATION
AB Introduction: Nonalcoholic fatty liver disease (NAFLD) is a major, worldwide public health problem. NAFLD is recognized as a major cause of liver-related morbidity and mortality. However, physicians are currently limited by available treatment options. Recently, numerous studies have reported a correlation between serum uric acid (SUA) and NAFLD with numerous clinical and experimental studies demonstrating a significant correlation. This review will focus on the role of SUA in the development of NAFLD and its potential role as a new target for therapeutic intervention.Areas covered: This review discusses SUA as a significant independent factor in the development of NAFLD. Moreover, we introduce the causal relationship between SUA, metabolic syndrome, and NAFLD. We discuss two major theories of insulin resistance and inflammasomes as potential explanations of the mechanistic link between SUA and NAFLD. In addition, we review current and emerging therapeutic medications to control appropriate SUA levels.Expert opinion: There is an urgent need to develop novel, safe and effective therapies for the growing NAFLD epidemic. Reduction of SUA may be a promising potential treatment for patients with NAFLD. Clinical studies are required to determine the therapeutic effect of attenuation of hyperuricemia in humans with NAFLD.
C1 [Sun, Dan-Qin; Lu, Qian-Di; Song, Dan] Nanjing Med Univ, Affiliated Wuxi Hosp 2, Dept Nephrol, Wuxi 214002, Peoples R China.
   [Wu, Sheng-Jie] Wenzhou Med Univ, Dept Cardiovasc Med, Ctr Heart, Affiliated Hosp 1, Wenzhou 325000, Peoples R China.
   [Liu, Wen-Yue] Wenzhou Med Univ, Dept Endocrinol, Affiliated Hosp 1, Wenzhou 325000, Peoples R China.
   [Zhu, Gui-Qi; Shi, Ke-Qing; Zheng, Ming-Hua] Wenzhou Med Univ, Dept Infect & Liver Dis, Affiliated Hosp 1, Liver Res Ctr, Wenzhou 325000, Peoples R China.
   [Zhu, Gui-Qi] Wenzhou Med Univ, Sch Clin Med Sci 1, Wenzhou 325000, Peoples R China.
   [Shi, Ke-Qing; Zheng, Ming-Hua] Wenzhou Med Univ, Inst Hepatol, Wenzhou 325000, Peoples R China.
   [Braddock, Martin] AstraZeneca R&D, Global Medicines Dev, Alderley Pk, England.
C3 Nanjing Medical University; Wenzhou Medical University; Wenzhou Medical
   University; Wenzhou Medical University; Wenzhou Medical University;
   Wenzhou Medical University; AstraZeneca
RP Song, D (corresponding author), Nanjing Med Univ, Affiliated Wuxi Hosp 2, Dept Nephrol, Wuxi 214002, Peoples R China.; Zheng, MH (corresponding author), Wenzhou Med Univ, Dept Infect & Liver Dis, Affiliated Hosp 1, Liver Res Ctr, Wenzhou 325000, Peoples R China.; Zheng, MH (corresponding author), Wenzhou Med Univ, Inst Hepatol, Wenzhou 325000, Peoples R China.
EM sdwx66@163.com; zhengmh@wmu.edu.cn
RI Liu, Wenyue/KDM-8848-2024; Zheng, Ming-Hua/H-5584-2019; Shi,
   KeQing/A-3411-2009; Zhu, Gui-Qi/H-9265-2017
OI Zheng, Ming-Hua/0000-0003-4984-2631; Liu, Wen-yue/0000-0003-1454-7077;
   Shi, KeQing/0000-0002-5070-3834; Zhu, Gui-Qi/0000-0001-5089-6923; Sun,
   Dan-Qin/0000-0002-8704-3606
FU National Natural Science Foundation of China [81500665]; Scientific and
   Technological Development Fundation of Nanjing Medical University Grants
   [2013NJMU190]; Scientific Research Foundation of Wenzhou, Zhejiang
   Province, China [H20090014, Y20090269]; Health Bureau of Zhejiang
   Province [2010KYB070]; Research Foundation of Education Bureau of
   Zhejiang Province [Y201009942]; Research Funds for Tian Qing Liver
   Diseases [TQGB20120057]; Project of New Century 551 Talent Nurturing in
   Wenzhou
FX This work was supported by grants from National Natural Science
   Foundation of China (81500665), Scientific and Technological Development
   Fundation of Nanjing Medical University Grants (2013NJMU190), the
   Scientific Research Foundation of Wenzhou, Zhejiang Province, China
   (H20090014, Y20090269), Health Bureau of Zhejiang Province (2010KYB070),
   Research Foundation of Education Bureau of Zhejiang Province
   (Y201009942), Research Funds for Tian Qing Liver Diseases (TQGB20120057)
   and Project of New Century 551 Talent Nurturing in Wenzhou. The authors
   have no other relevant affiliations or financial involvement with any
   organization or entity with a financial interest in or financial
   conflict with the subject matter or materials discussed in the
   manuscript apart from those disclosed.
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NR 84
TC 26
Z9 29
U1 0
U2 29
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1472-8222
EI 1744-7631
J9 EXPERT OPIN THER TAR
JI Expert Opin. Ther. Targets
PD MAR 3
PY 2016
VL 20
IS 3
BP 375
EP 387
DI 10.1517/14728222.2016.1096930
PG 13
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA DD8GV
UT WOS:000370165100001
PM 26419119
DA 2025-06-11
ER

PT J
AU Tükel, HC
   Alptekin, Ö
   Turan, B
   Delilbasi, E
AF Tukel, H. Can
   Alptekin, Ozlem
   Turan, Belma
   Delilbasi, Ertan
TI Effects of metabolic syndrome on masseter muscle of male Wistar rats
SO EUROPEAN JOURNAL OF ORAL SCIENCES
LA English
DT Article
DE ATPases; masseter muscle; metabolic syndrome; superoxide dismutase;
   trace elements
ID OXIDATIVE STRESS; LIPID-PEROXIDATION; INSULIN-RESISTANCE;
   SKELETAL-MUSCLE; TRACE-ELEMENTS; DIABETES-MELLITUS; REACTIVE OXYGEN;
   NITRIC-OXIDE; DAMAGE; DIET
AB The aim of this study was to investigate the association between metabolic syndrome (MetS) and the metabolic indicators of masticatory muscles in an animal model. A total of 16 male Wistar rats were used. To induce MetS, 10 rats were fed with standard rat chow and 32% sucrose solution ad libitum for 16 wk. Six rats fed with standard rat chow and water ad libitum formed the control group. All rats were killed at week 16, and the right superficial masseter muscles were harvested. Metabolic indicators of masticatory muscle metabolism, including antioxidant enzyme activities, ion transport ATPase activities, and the levels of macro and trace elements, were determined in the muscles. Superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase activities were significantly decreased by 32%, 26%, 33%, and 16%, respectively, in the MetS group. Na+/K+-ATPase activity was significantly decreased in the MetS group by 54% compared with the control group. The levels of chromium and selenium were significantly decreased, and the level of copper was increased, in the MetS group compared with the control group. These results show that significant alterations occurred in antioxidant defense mechanisms, ion transport mechanisms, and trace element levels of masseter muscles in MetS.
C1 [Tukel, H. Can] Cukurova Univ, Dept Oral & Maxillofacial Surg, Fac Dent, TR-01330 Adana, Turkey.
   [Alptekin, Ozlem] Cukurova Univ, Dept Biochem, Fac Pharm, TR-01330 Adana, Turkey.
   [Turan, Belma] Ankara Univ, Dept Biophys, Fac Med, TR-06100 Ankara, Turkey.
   [Delilbasi, Ertan] Gazi Univ, Dept Oral & Maxillofacial Surg, Fac Dent, Ankara, Turkey.
C3 Cukurova University; Cukurova University; Ankara University; Gazi
   University
RP Tükel, HC (corresponding author), Cukurova Univ, Dept Oral & Maxillofacial Surg, Fac Dent, TR-01330 Adana, Turkey.
EM ctukel@cu.edu.tr
RI TURAN, Belma/AAG-8084-2020; Alptekin, Ozlem/A-3233-2016; tukel, huseyin
   can/J-9250-2018
OI TURAN, Belma/0000-0003-2583-9294; Alptekin, Ozlem/0000-0002-0458-7609;
   tukel, huseyin can/0000-0002-6723-0842
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NR 51
TC 3
Z9 3
U1 0
U2 8
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0909-8836
EI 1600-0722
J9 EUR J ORAL SCI
JI Eur. J. Oral Sci.
PD DEC
PY 2015
VL 123
IS 6
BP 432
EP 438
DI 10.1111/eos.12226
PG 7
WC Dentistry, Oral Surgery & Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dentistry, Oral Surgery & Medicine
GA CX5RJ
UT WOS:000365759800008
PM 26521868
DA 2025-06-11
ER

PT J
AU Mehra, S
   Kapur, S
   Mittal, S
   Sehgal, PK
AF Mehra, Shipra
   Kapur, Suman
   Mittal, Saumyaa
   Sehgal, Pramod Kumar
TI Common genetic link between metabolic syndrome components and senile
   cataract
SO FREE RADICAL RESEARCH
LA English
DT Article
DE D2S439; SPHKAP gene; MDA levels; visceral adiposity; metabolic syndrome
ID AGE-RELATED CATARACT; HUMAN OBESITY; RISK-FACTORS; POPULATION; FAT; SCAN
AB Relationship between cataract and metabolic syndrome (MetS) is well established, but genetic link remains to be explored. D2S439 at 2q37 linked with QTL controlling visceral fat was investigated for its association with senile cataract. Two hundred and twenty-seven subjects including 119 cataract cases were genotyped for D2S439, tetra nucleotide repeat marker. Statistical tools assessed the association of marker's allele with anthropometric, clinical and oxidation stress parameters. Cases with longer allele >= (CTAT)(12) repeats, differed significantly from controls (0.77 vs. 0.58, p < 0.0001). Cases with at least one longer allele had higher waist circumference (50% vs. 15%, p = 0.0090), hyper-triglyceridemia (28% vs. 11%), hypo-HDL cholesterolemia (80% vs. 74%) and high diastolic blood pressure (37% vs. 26%) when compared to cases bearing the shorter allele. Cataract subjects with at least one longer allele had significantly raised lipid peroxidation levels (p = 0.0095) and showed an increased risk for cataract (OR = -5.86, CI95% = 1.49-23.11, p = 0.0114) after controlling for dependent variables. This exploratory study suggests that presence of even a single longer allele of D2S439 is associated with both cataract and MetS components in Asian Indians, unraveling the existence of a shared genetic locus.
C1 [Kapur, Suman] Birla Inst Technol & Sci Pilani, Dept Biol Sci, Hyderabad 500078, Andhra Pradesh, India.
   [Sehgal, Pramod Kumar] Mahadev Singhi Eye Hosp, Pilani, Rajasthan, India.
   [Mittal, Saumyaa] Uniform Serv Univ Hlth Sci, Bethesda, MD USA.
C3 Birla Institute of Technology & Science Pilani (BITS Pilani)
RP Kapur, S (corresponding author), Birla Inst Technol & Sci Pilani, Dept Biol Sci, Hyderabad Campus, Hyderabad 500078, Andhra Pradesh, India.
EM kapur@bits-pilani.ac.in
FU Indian Council of Medical Research, Government of India; Indian Council
   of Medical Research, New Delhi; ICMR
FX This work was supported, in part, by grants from Indian Council of
   Medical Research, Government of India. The study was supported by funds
   in the form of extramural grants from Indian Council of Medical
   Research, New Delhi to Dr. Suman Kapur and Senior research fellowship
   from ICMR to Mrs. Shipra Mehra. No conflict of interest exists between
   authors. The authors alone are responsible for the content and writing
   of the paper.
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NR 37
TC 3
Z9 3
U1 0
U2 5
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1071-5762
EI 1029-2470
J9 FREE RADICAL RES
JI Free Radic. Res.
PD FEB
PY 2012
VL 46
IS 2
BP 133
EP 140
DI 10.3109/10715762.2011.645205
PG 8
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 884ZS
UT WOS:000299748000003
PM 22165987
DA 2025-06-11
ER

PT J
AU Luo, T
   Snyder, SM
   Zhao, BX
   Sullivan, DK
   Hamilton-Reeves, J
   Guthrie, G
   Ricketts, ML
   Shiverick, KT
   Shay, N
AF Luo, Ting
   Snyder, Sarah M.
   Zhao, Bingxin
   Sullivan, Debra K.
   Hamilton-Reeves, Jill
   Guthrie, Gregory
   Ricketts, Marie-Louise
   Shiverick, Kathleen T.
   Shay, Neil
TI Gene Expression Patterns Are Altered in Athymic Mice and Metabolic
   Syndrome Factors Are Reduced in C57BL/6J Mice Fed High-Fat Diets
   Supplemented with Soy Isoflavones
SO JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
LA English
DT Article
DE metabolic syndrome; isoflavones; genistein; oxidation; inflammation;
   lipid metabolism
ID ACTIVATED RECEPTOR-ALPHA; LIVER-DISEASE; PEROXISOME PROLIFERATOR;
   INSULIN-RESISTANCE; POSTMENOPAUSAL WOMEN; PROSTATE-CANCER;
   BLOOD-GLUCOSE; IN-VITRO; GENISTEIN; METAANALYSIS
AB Soy isoflavones exert beneficial health effects; however, their potential to ameliorate conditions associated with the metabolic syndrome (MetS) has not been studied in detail. In vitro and in vivo models were used to determine the effect of isoflavones on lipid metabolism, inflammation, and oxidative stress. In nude mice, consumption of Novasoy (NS) increased cholesterol and lipid metabolism gene expression, including Scd-1 (27.7-fold), Cyp4a14 (35.2-fold), and Cyp4a10 (9.5-fold), and reduced anti-inflammatory genes, including Cebpd (16.4-fold). A high-fat (HF) diet containing 0.4% (w/w) NS for 10 weeks significantly reduced percent weight gain (74.6 +/- 2.5 vs 68.6 +/- 3.5%) and hepatic lipid accumulation (20 +/- 1.2 vs 27 +/- 1.5%), compared to HF alone (p < 0.05) in C57BL/6J mice. NS also increased lipid oxidation and antioxidant gene expression while decreasing inflammatory cytokines. In vitro analysis in HepG2 cells revealed that genistein dose-dependently decreases oleic acid induced lipid accumulation. Soy isoflavones may ameliorate symptoms associated with MetS via anti-inflammatory, antioxidant, and hypolipidemic modulation.
C1 [Luo, Ting; Snyder, Sarah M.; Zhao, Bingxin; Shay, Neil] Oregon State Univ, Food Sci & Technol, Corvallis, OR 97330 USA.
   [Sullivan, Debra K.; Hamilton-Reeves, Jill] Kansas Univ, Dietet & Nutr, Med Ctr, Kansas City, KS 66160 USA.
   [Guthrie, Gregory] Baylor Coll Med, Houston, TX 77030 USA.
   [Ricketts, Marie-Louise] Univ Nevada, Agr Nutr & Vet Sci, Reno, NV 89557 USA.
   [Shiverick, Kathleen T.] Univ Florida, Coll Med, Pharmacol, Gainesville, FL 32610 USA.
C3 Oregon State University; University of Kansas; University of Kansas
   Medical Center; Baylor College of Medicine; Nevada System of Higher
   Education (NSHE); University of Nevada Reno; State University System of
   Florida; University of Florida
RP Shay, N (corresponding author), Dept Food Sci & Technol, 202 Wiegand Hall,3051 SW Campus Way, Corvallis, OR 97330 USA.
EM neil.shay@oregonstate.edu
RI Luo, Ting/O-7773-2019; Ricketts, Marie/LDG-8176-2024; Guthrie,
   Gregory/ABI-4949-2022
OI Ricketts, Marie-Louise/0000-0002-8306-7563
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NR 58
TC 13
Z9 13
U1 2
U2 15
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0021-8561
EI 1520-5118
J9 J AGR FOOD CHEM
JI J. Agric. Food Chem.
PD OCT 12
PY 2016
VL 64
IS 40
BP 7492
EP 7501
DI 10.1021/acs.jafc.6b03401
PG 10
WC Agriculture, Multidisciplinary; Chemistry, Applied; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture; Chemistry; Food Science & Technology
GA DY9QJ
UT WOS:000385469900010
PM 27653593
DA 2025-06-11
ER

PT J
AU Tian, FS
   Luo, R
   Zhao, ZQ
   Wu, Y
   Ban, DJ
AF Tian, F. S.
   Luo, R.
   Zhao, Z. Q.
   Wu, Y.
   Ban, D. J.
TI Blockade of the RAS increases Plasma Adiponectin in Subjects with
   Metabolic Syndrome and Enhances Differentiation and Adiponectin
   Expression of Human Preadipocytes
SO EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
LA English
DT Article
DE renin-angiotensin system; preadipocytes; metabolic syndrome; cell
   differentiation; adiponectin
ID RENIN-ANGIOTENSIN SYSTEM; ADIPOSE-TISSUE; PPAR-GAMMA; OXIDATIVE STRESS;
   ADIPOCYTES; HYPERTENSION; TELMISARTAN; INHIBITION; RECEPTORS; INDUCTION
AB This observational study aimed to investigate the effects of renin-angiotensin system (RAS) blockers on plasma adiponectin in subjects with metabolic syndrome (Mets) and differentiation, adiponectin expression of human omental (OM) and subcutaneous (SC) preadipocytes.
   Fifty-three patients with Mets were treated with angiotensin converting enzyme inhibition (ACEI), angiotensin II receptor blocker (ARB) or nothing, lipid profile and adiponetin were measured. OM and SC preadipocytes were obtained from sixteen normal non-menopausal women undergoing elective abdominal surgery and subsequently differentiated in the presence of ACE, ARB or thiazolidinedione (TZD). Differentiation was assessed using a number of biochemical and function parameters.
   Plasma adiponectin was increased dramatically as a result of ACEI and ARB treatment. Most of the metabolic and differentiating parameters were improved significantly by RAS blockers or TZD. Compared with TZD, RAS blockers have stronger effects on omental preadipocytes in differentiation and insulin sensitivity. The improvement of adiponectin mRNA expression was significantly greater in ARB-treated omental preadipocytes compared with TZD-treated ones.
   These results suggest that adiponectin may serve as potential therapeutic targets of ACEI and ARB for treating the Mets and its related complications. It also suggests a potential benefit of RAS blockers on Mets with characteristic visceral obesity.
C1 Tianjin Gong An Hosp, Dept Med, Tianjin, Peoples R China.
   Tianjin Gong An Hosp, Dept Surg, Tianjin, Peoples R China.
RP Luo, R (corresponding author), 78 Nanjing Rd, Tianjin 300042, Peoples R China.
EM starelr_99@126.com
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NR 35
TC 26
Z9 33
U1 0
U2 1
PU JOHANN AMBROSIUS BARTH VERLAG MEDIZINVERLAGE HEIDELBERG GMBH
PI STUTTGART
PA RUEDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0947-7349
EI 1439-3646
J9 EXP CLIN ENDOCR DIAB
JI Exp. Clin. Endocrinol. Diabet.
PD APR
PY 2010
VL 118
IS 4
BP 258
EP 265
DI 10.1055/s-0029-1237706
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 590VZ
UT WOS:000277257700009
PM 19856251
DA 2025-06-11
ER

PT J
AU Lapinska, L
   Krentowska, A
   Kondraciuk, M
   Chlabicz, M
   Waszkiewicz, N
   Kaminski, K
   Kowalska, I
AF Lapinska, Lidia
   Krentowska, Anna
   Kondraciuk, Marcin
   Chlabicz, Malgorzata
   Waszkiewicz, Napoleon
   Kaminski, Karol
   Kowalska, Irina
TI The association between plasma N-terminal pro-brain natriuretic peptide
   concentration and metabolic disturbances in women with depressive
   symptoms
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE Depressive symptoms; NT-proBNP; Insulin resistance; Metabolic syndrome
ID HEART
AB Background: The relationship between brain natriuretic peptides and depression was studied in patients with cardiovascular diseases (CVD), but the data in people without CVD are limited. Metabolic disturbances can be associated with natriuretic peptides' levels. The study aimed to assess serum N-terminal pro-brain natriuretic peptide (NT-proBNP) level in women with depressive symptoms and its relationship with metabolic disturbances.Methods: The analysis included 347 women (20-60 years old) from Bialystok PLUS cohort study: 98 with depressive symptoms and 249 controls. Clinical examination, oral glucose tolerance test (OGTT) and assessment of lipid, sex hormone binding globulin (SHBG) and NT-proBNP concentrations in the blood were performed. The participants completed Beck Depression Inventory questionnaire.Results: Metabolic syndrome was more frequent in the group of women with depressive symptoms compared to women without depressive symptoms. Women with depressive symptoms had lower NT-proBNP level than the control group -45.88 (27.80-67.04) vs 56.49 (32.42-94.25) pg/mL, p = 0.027. Multiple linear regression analysis of all women showed that NT-proBNP level was reversely associated with the presence of depressive symptoms, waist circumference and heart rate and positively connected with age. In the group of women with depressive symptoms, we observed negative correlations between NT-proBNP level and insulin concentration at 60 min of OGTT, diastolic blood pressure and a positive correlation with SHBG.Conclusions: NT-proBNP level is decreased in women with depressive symptoms, which might be connected with metabolic disturbances in this group.
C1 [Lapinska, Lidia; Krentowska, Anna; Kowalska, Irina] Med Univ Bialystok, Dept Internal Med & Metab Dis, Bialystok, Poland.
   [Kondraciuk, Marcin] Med Univ Bialystok, Populat Res Ctr, Bialystok, Poland.
   [Chlabicz, Malgorzata; Kaminski, Karol] Med Univ Bialystok, Dept Populat Med & Lifestyle Dis Prevent, Bialystok, Poland.
   [Waszkiewicz, Napoleon] Med Univ Bialystok, Dept Psychiat, Bialystok, Poland.
   [Lapinska, Lidia] Med Univ Bialystok, Dept Internal Med & Metab Dis, M Sklodowskiej Curie 24a, PL-15276 Bialystok, Poland.
C3 Medical University of Bialystok; Medical University of Bialystok;
   Medical University of Bialystok; Medical University of Bialystok;
   Medical University of Bialystok
RP Lapinska, L (corresponding author), Med Univ Bialystok, Dept Internal Med & Metab Dis, M Sklodowskiej Curie 24a, PL-15276 Bialystok, Poland.
EM lidia.lapinska@umb.edu.pl
RI Kaminski, Karol/J-4515-2014; Chlabicz, Malgorzata/AAZ-9550-2020;
   Waszkiewicz, Napoleon/AAI-5530-2020; Krentowska, Anna/GYU-3703-2022
OI Chlabicz, Malgorzata/0000-0002-5113-5672; Krentowska,
   Anna/0000-0001-5959-5481; Kondraciuk, Marcin/0000-0002-4516-7467
FU Municipal Office in Bialystok [W/UB/DSP/1640/UMBIALYSTOK/2017]; Medical
   University of Bialystok for the Bialystok PLUS study
   [SUB/1/00/19/001/1201]
FX Bialystok PLUS study was supported by the Municipal Office in Bialystok
   (grant Number W/UB/DSP/1640/UMBIA LYSTOK/2017) and from funds from the
   Medical University of Bialystok for the Bialystok PLUS study (grant
   Number SUB/1/00/19/001/1201) .
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NR 32
TC 2
Z9 2
U1 0
U2 0
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
EI 1873-3360
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD DEC
PY 2023
VL 158
AR 106409
DI 10.1016/j.psyneuen.2023.106409
EA OCT 2023
PG 5
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA U7XN6
UT WOS:001086898200001
PM 37801752
DA 2025-06-11
ER

PT J
AU Adachi, N
   Kobayashi, Y
AF Adachi, Naoko
   Kobayashi, Yasuki
TI One-year follow-up study on associations between dental caries,
   periodontitis, and metabolic syndrome
SO JOURNAL OF ORAL SCIENCE
LA English
DT Article
DE dental caries; DMFT; metabolic syndrome; oral health; periodontitis;
   tooth loss
ID ORAL BACTERIA; DISEASE; INFECTION; TEETH; INFLAMMATION; INDUCTION;
   BREAKFAST; STRESS; NUMBER; RISK
AB There have been few prospective studies on the relationship between oral health conditions and the development of metabolic syndrome (MetS). This prospective cohort study was performed at a Japanese company over one year. Routine medical health examinations, oral health examinations, and a questionnaire pertaining to education, job type, and health behaviors was administered. Participants aged >= 35 years who had no MetS components at baseline were re-examined after one year. Modified Poisson regression analyses were performed to calculate the relative risks (RRs) associated with oral health variables, including periodontitis, decayed and missing teeth, and decayed, missing, and filled teeth (DMFT) in relation to the development of MetS. Of 152 eligible participants, 136 were re-examined after one year; 30 exhibited one or more newly developed MetS components upon re-examination. Decayed teeth at baseline were significantly associated with development of at least one MetS component (adjusted RR 3.25, 95% confidence interval 1.59-6.63). There were no associations between periodontitis, missing teeth, or DMFT and the development of MetS. The association between decayed teeth and MetS was independent of other risk factors, including age and body mass index; therefore, decayed teeth may be associated with the development of MetS.
C1 [Adachi, Naoko] Tokyo Med & Dent Univ, Grad Sch Med & Dent Sci, Dept Prevent Oral Hlth Care Sci, Tokyo, Japan.
   [Adachi, Naoko; Kobayashi, Yasuki] Univ Tokyo, Grad Sch Med, Dept Publ Hlth, Tokyo, Japan.
C3 Institute of Science Tokyo; Tokyo Medical & Dental University (TMDU);
   University of Tokyo
RP Adachi, N (corresponding author), Tokyo Med & Dent Univ, Grad Sch Med & Dent Sci, Dept Prevent Oral Hlth Care Sci, Bunkyo Ku, 1-5-45 Yushima, Tokyo 1138510, Japan.
EM adachi.pvoh@tmd.ac.jp
OI Adachi, Naoko/0000-0002-9802-9914; Kobayashi, Yasuki/0000-0002-9616-0687
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NR 38
TC 15
Z9 15
U1 1
U2 6
PU NIHON UNIV, SCHOOL DENTISTRY
PI TOYKO
PA 1--13 KANDA-SURUGADAI, CHIYODA-KU, TOYKO, 101-8310, JAPAN
SN 1343-4934
EI 1880-4926
J9 J ORAL SCI
JI J. Oral Sci.
PD JAN
PY 2020
VL 62
IS 1
BP 52
EP 56
DI 10.2334/josnusd.18-0251
PG 5
WC Dentistry, Oral Surgery & Medicine; Materials Science, Biomaterials
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dentistry, Oral Surgery & Medicine; Materials Science
GA KG5HX
UT WOS:000509980100012
PM 31996523
OA gold
DA 2025-06-11
ER

PT J
AU Rzheshevsky, AV
AF Rzheshevsky, A. V.
TI Decrease in ATP biosynthesis and dysfunction of biological membranes.
   Two possible key mechanisms of phenoptosis
SO BIOCHEMISTRY-MOSCOW
LA English
DT Review
DE fatty acids; leptin; insulin; AMP-activated protein kinase; mTOR;
   oxidative stress; apoptosis; phenoptosis; biomembranes dysfunction;
   mitochondria; endoplasmic reticulum
ID ENDOPLASMIC-RETICULUM STRESS; ACTIVATED PROTEIN-KINASE;
   NECROSIS-FACTOR-ALPHA; FATTY-ACID; METABOLIC SYNDROME; SKELETAL-MUSCLE;
   IKK-BETA; KAPPA-B; LEPTIN; EXPRESSION
AB Metabolic syndrome is extremely prevalent in the world and can be considered as one of main factors leading to accelerated aging and premature death. This syndrome may be closely linked with age-related disruptions in hypothalamic-pituitary system function, which perhaps represent a trigger mechanism of development of endocrine and cardiovascular pathologies. Age-related elevation of the sensitivity threshold of the hypothalamus to regulatory signals in association with low mobility and excessive diet trigger a cascade of biochemical reactions that might be used for activation of programmed death of the organism - phenoptosis. Accumulation of fatty acids in a cell and resulting lipotoxicity include resistance to insulin and leptin, endoplasmic reticulum stress, uncoupling of oxidation and phosphorylation, and dysfunction of biological membranes. Decrease in ATP synthesis is correlated with accumulation of calcium ions in cells, dysfunction of mitochondria, and increasing apoptotic activity. Age-related activation of mTOR (which is greatly influenced by excess energy substrates) has deleterious impact on one of the main mechanisms of cell defense by which defective mitochondria are replaced: mitophagy and biogenesis of mitochondria will be suppressed, and this will increase in greater degree mitochondrial dysfunction and oxidative stress. Fatty acid-induced inflammation will increase activity of nuclear factor NF-kappa B, the well-known stimulator of age-related pathologies. The final stage of phenoptosis can be represented by endothelium dysfunction related with oxidative stress, insulin resistance, and the most prevalent cardiovascular pathologies.
C1 Ctr Rehabil Med, UA-49000 Dnepropetrovsk, Ukraine.
RP Rzheshevsky, AV (corresponding author), Ctr Rehabil Med, Ul Mech 8, UA-49000 Dnepropetrovsk, Ukraine.
EM alex-rjechewsky@mail.ru
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NR 108
TC 8
Z9 8
U1 0
U2 9
PU MAIK NAUKA/INTERPERIODICA/SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013-1578 USA
SN 0006-2979
EI 1608-3040
J9 BIOCHEMISTRY-MOSCOW+
JI Biochem.-Moscow
PD OCT
PY 2014
VL 79
IS 10
BP 1056
EP 1068
DI 10.1134/S0006297914100071
PG 13
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA AR7ID
UT WOS:000343751900007
PM 25519064
DA 2025-06-11
ER

PT J
AU Logvinov, SV
   Mukhomedzyanov, AV
   Kurbatov, BK
   Sirotina, MA
   Naryzhnaya, NV
   Maslov, LN
AF Logvinov, S. V.
   Mukhomedzyanov, A. V.
   Kurbatov, B. K.
   Sirotina, M. A.
   Naryzhnaya, N. V.
   Maslov, L. N.
TI Participation of Leptin and Corticosterone in the Decrease in
   Infarct-Limiting Efficiency of Remote Postconditioning and in the
   Development of Arterial Hypertension in Metabolic Syndrome in Rats
SO BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
LA English
DT Article
DE remote postconditioning; metabolic syndrome; myocardium; leptin;
   corticosterone
AB We studied the effect of induced metabolic syndrome (MetS) on the effectiveness of the infarct-limiting effect of remote ischemic postconditioning (RP) in Wistar rats. The involvement of leptin and corticosterone in the formation of arterial hypertension (AH) and in reduction of the effectiveness of RP in MetS was also studied. MetS was induced by high-carbohydrate high-fat diet with replacement of drinking water with 20% fructose solution for 90 days. MetS simulation led to obesity, AH, impaired lipid and carbohydrate metabolism, hyperleptinemia, and moderate stress. All animals were subjected to 45-min coronary occlusion and 120-min reperfusion. In the RP groups, tourniquets were applied on the hind limbs in the area of the hip joint immediately after the end of ischemia (3 cycles consisting of 5-min ischemia and 5-min reperfusion). A direct correlation was found between the severity of AH in rats with MetS and the levels of corticosterone and leptin. In rats with MetS, the effectiveness of RP decreased: a direct correlation between the infarct size and serum content of leptin was revealed in rats with MetS+RP. Corticosterone seems to be one of the factors of AH development in rats with MetS.
C1 [Logvinov, S. V.; Mukhomedzyanov, A. V.; Kurbatov, B. K.; Sirotina, M. A.; Naryzhnaya, N. V.; Maslov, L. N.] Russian Acad Sci, Cardiol Res Inst, Tomsk Natl Res Med Ctr, Tomsk, Russia.
   [Logvinov, S. V.] Siberian State Med Univ, Minist Hlth Russian Federat, Tomsk, Russia.
C3 Russian Academy of Sciences; Tomsk National Research Medical Center;
   Cardiology Research Institute - Tomsk; Ministry of Health of the Russian
   Federation; Siberian State Medical University
RP Naryzhnaya, NV (corresponding author), Russian Acad Sci, Cardiol Res Inst, Tomsk Natl Res Med Ctr, Tomsk, Russia.
EM natalynar@yandex.ru
RI Naryzhnaya, Natalia/F-5310-2017; Maslov, Leonid/Q-7308-2016; Курбатов,
   Борис/AAG-9307-2021; Mukhomedzyanov, Alexander/Q-5752-2016
OI Mukhomedzyanov, Alexander/0000-0003-1808-556X
FU Russian Science Foundation [22-25-20001]; Administration of the Tomsk
   Region
FX The work was supported by the Russian Science Foundation (grant No.
   22-25-20001; https://rscf.ru/project/22-25-20001) and Administration of
   the Tomsk Region. Studies of the mechanisms of AH in induced
   <EM><STRONG> </STRONG></EM>MetS were carried out within the framework of
   the State Assignment No. 122020300042-4. The work was performed using
   the equipment of the Common Use Center "Medical Genomics".
CR Baranyai T, 2015, CARDIOVASC DIABETOL, V14, DOI 10.1186/s12933-015-0313-1
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NR 15
TC 2
Z9 2
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0007-4888
EI 1573-8221
J9 B EXP BIOL MED+
JI Bull. Exp. Biol. Med.
PD JAN
PY 2023
VL 174
IS 3
BP 312
EP 317
DI 10.1007/s10517-023-05698-1
EA FEB 2023
PG 6
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 8O5KT
UT WOS:000925043400019
PM 36723738
DA 2025-06-11
ER

PT J
AU Rajagopalan, P
   Dixit, S
   Alahmari, K
   Devenesan, CS
   Rengaramanujam, K
   Zaman, GS
   Asiri, HA
   Chandramoorthy, HC
AF Rajagopalan, Prasanna
   Dixit, Snehil
   Alahmari, Khalid
   Stephen Devenesan, Charles
   Rengaramanujam, Kanagaraj
   Sarwar Zaman, Gaffar
   Ali Asiri, Hateem
   Chandramoorthy, Harish C.
TI Resistance training influences Adipokines and various biochemical
   factors altering the risk of metabolic syndrome in young male obese
   students
SO MEDICINA DELLO SPORT
LA English
DT Article
DE Adiponectin; Leptin; Metabolic syndrome; Obesity; Resistin; Resistance
   training
ID SALT-SENSITIVE HYPERTENSION; BODY-MASS INDEX; INSULIN-RESISTANCE;
   CARDIOVASCULAR-DISEASE; SERUM ADIPONECTIN; OXIDATIVE STRESS; LEPTIN
   LEVELS; INFLAMMATION; ADOLESCENTS; CHILDREN
AB BACKGROUND: Young obese adults have a very high risk of developing metabolic syndromes (MetS). I he predisposing factors like adipokines, lipid profile, inflammatory cytokines and antioxidant enzyme status between the sedentary and active life style in young obese individuals have not been elaborately studied. The physiological relationship and impact of resistance trainings over obesity inducing factors in young male obese individuals who are at risk for metabolic syndrome (Mets) were evaluated.
   METHODS: Blood samples were collected before and at different time points of light to moderate and resistance trainings. Adipocytokines, obesity hormones, pro-inflammatory cytokines, lipid profile and antioxidant enzymes were measured using standard spectrophotometric and FLISA methods.
   RESULTS: A proportional increase in adiponectin and HLD-c has been observed post 5th and 10th weeks with respect to control groups. A gradual decrease in lecithin, resistin, SOD, GPx along with TNF alpha and IL-6 were hall mark observations post 5th and 10th week resistance training. There was no significant alternation in obesity inducing factors for non-obese control and light to moderate exercise groups.
   CONCLUSIONS: Resistance training proves beneficial in lowering obesity inducing factors in young obese adults.
C1 [Rajagopalan, Prasanna; Stephen Devenesan, Charles; Sarwar Zaman, Gaffar; Ali Asiri, Hateem] King Khalid Univ, Coll Appl Med Sci, Dept Clin Lab Sci, POB 641, Abha, Saudi Arabia.
   [Dixit, Snehil; Alahmari, Khalid; Rengaramanujam, Kanagaraj] King Khalid Univ, Coll Appl Med Sci, Dept Med Rehabil Sci, Abha, Saudi Arabia.
   [Chandramoorthy, Harish C.] King Khalid Univ, Coll Med, Ctr Stem Cell Res, Abha, Saudi Arabia.
   [Chandramoorthy, Harish C.] King Khalid Univ, Coll Med, Dept Microbiol & Clin Parasitol, Abha, Saudi Arabia.
C3 King Khalid University; King Khalid University; King Khalid University;
   King Khalid University
RP Rajagopalan, P (corresponding author), King Khalid Univ, Coll Appl Med Sci, Dept Clin Lab Sci, POB 641, Abha, Saudi Arabia.
EM rajagopalan@kku.edu.sa
RI Chandramoorthy, Harish/JAC-4762-2023; RENGARAMANUJAM,
   KANAGARAJ/AAT-9174-2020; Dixit, Snehil/H-2757-2019; Alahmari,
   Khalid/AGK-4892-2022; ZAMAN, DR GAFFAR SARWAR/AAQ-8764-2021
OI Rajagopalan, Prasanna/0000-0001-7593-7234; Dixit,
   Snehil/0000-0003-1617-6935; RENGARAMANUJAM,
   KANAGARAJ/0000-0002-0244-7645; ZAMAN, DR GAFFAR
   SARWAR/0000-0002-8740-3990
FU King Khalid University, Abha, Saudi Arabia [G.R.P-97-1438]
FX The research was funded by the Deanship of Scientific Research, King
   Khalid University, Abha, Saudi Arabia (project number G.R.P-97-1438).
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NR 50
TC 2
Z9 2
U1 1
U2 8
PU EDIZIONI MINERVA MEDICA
PI TURIN
PA CORSO BRAMANTE 83-85 INT JOURNALS DEPT., 10126 TURIN, ITALY
SN 0025-7826
EI 1827-1863
J9 MED SPORT
JI Med. Sport
PD DEC
PY 2018
VL 71
IS 4
BP 561
EP +
DI 10.23736/S0025-7826.18.03431-2
PG 19
WC Medicine, General & Internal; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Sport Sciences
GA HI5GY
UT WOS:000456481700007
DA 2025-06-11
ER

PT J
AU Oliva, MM
   Minutolo, E
   Lippa, A
   Iaconianni, P
   Vaiarelli, A
AF Oliva, Mario Montanino
   Minutolo, Elisa
   Lippa, Assunta
   Iaconianni, Paola
   Vaiarelli, Alberto
TI Effect of Myoinositol and Antioxidants on Sperm Quality in Men with
   Metabolic Syndrome
SO INTERNATIONAL JOURNAL OF ENDOCRINOLOGY
LA English
DT Article
ID INOSITOL TRISPHOSPHATE; MITOCHONDRIAL-FUNCTION; INSULIN-RESISTANCE; MALE
   REPRODUCTION; OXIDATIVE STRESS; OBESITY; ARGININE; SPERMATOZOA;
   VITALITY; SELENIUM
AB This prospective longitudinal study investigated the effects of a dietary supplement in patients affected by reduced sperm motility (asthenospermic males) with metabolic syndrome. The product tested was Andrositol (R), which contains myoinositol (MI) as principal compound, in association with other molecules, and the parameters evaluated were semen characteristics as well as hormone and metabolic profiles. The inclusion criteria were subjects aged over 18 years, with asthenospermia and metabolic syndrome. The exclusion criteria were presence of cryptorchidism, varicocele, and prostatitis. For this study, 45 males who had such features were enrolled. Their selection was made according to the 2010 World Health Organization (WHO) criteria (5th Edition) for the Evaluation of Human Semen. Hormone and metabolic profiles and semen parameters were assessed at the beginning of the study and after three months of treatment with Andrositol. The differences between the values before and after the supplementation were found statistically significant. Andrositol normalized the metabolic profile of these patients, improving their insulin sensitivity. Moreover, testosterone levels were increased and the semen characteristics, such as sperm concentration, motility, and morphology, highly improved. In conclusion, the association of MI with other molecules (micronutrients and vitamins) could be an effective therapy for metabolic disorders, as well as hormonal and spermatic changes responsible for male infertility.
C1 [Oliva, Mario Montanino] Santo Spirito Hosp, Dept Obstet & Gynecol, I-00193 Rome, Italy.
   [Oliva, Mario Montanino; Minutolo, Elisa; Lippa, Assunta; Iaconianni, Paola] Altamed IVF Unit, I-00198 Rome, Italy.
   [Vaiarelli, Alberto] Univ Hosp, Reprod Med Unit, I-98122 Messina, Italy.
C3 AOU Policlinico Gaetano Martino
RP Oliva, MM (corresponding author), Santo Spirito Hosp, Dept Obstet & Gynecol, I-00193 Rome, Italy.; Oliva, MM (corresponding author), Altamed IVF Unit, I-00198 Rome, Italy.
EM mario.montanino@virgilio.it
RI Oliva, Mario/AAG-9711-2019
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NR 61
TC 19
Z9 19
U1 0
U2 0
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1687-8337
EI 1687-8345
J9 INT J ENDOCRINOL
JI Int. J. Endocrinol.
PY 2016
VL 2016
AR 1674950
DI 10.1155/2016/1674950
PG 5
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA DY4TC
UT WOS:000385091300001
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Palomo, I
   Contreras, A
   Alarcón, LM
   Leiva, E
   Guzmán, L
   Mujica, V
   Icaza, G
   Díaz, N
   González, DR
   Moore-Carrasco, R
AF Palomo, Ivan
   Contreras, Alejandra
   Marcelo Alarcon, L.
   Leiva, Elba
   Guzman, Luis
   Mujica, Veronica
   Icaza, Gloria
   Diaz, Nora
   Gonzalez, Daniel R.
   Moore-Carrasco, Rodrigo
TI Elevated concentration of asymmetric dimethylarginine (ADMA) in
   individuals with metabolic syndrome
SO NITRIC OXIDE-BIOLOGY AND CHEMISTRY
LA English
DT Article
DE Metabolic syndrome; Endothelial dysfunction; Nitric oxide inhibitor;
   Asymmetric dimethyl arginine; Oxidative stress; Insulin resistance
ID NITRIC-OXIDE SYNTHASE; INSULIN-RESISTANCE; POTENTIAL LINK; PLASMA;
   DISEASE; OBESITY; RISK; ADHESIVENESS; CHOLESTEROL; DYSFUNCTION
AB The metabolic syndrome (MS) is a cluster of pathophysiological alterations that includes the presence of hypertension, insulin resistance, dyslipidemia, and abdominal obesity. MS is associated with increased risk of developing diabetes and cardiovascular diseases. Endothelial dysfunction with impaired nitric oxide (NO) bioavailability has been implicated in insulin resistance and hypertension. NO is synthesized by nitric oxide synthase (NOS) using L-arginine as substrate. Asymmetric dimethyl arginine (ADMA) is a major and potent endogenous NOS inhibitor, associated with cardiovascular and renal diseases. We tested the hypothesis that plasmatic ADMA levels are increased in patients with MS.
   We studied 85 adult individuals from Talca, Chile, separated in two groups, 48 individuals with MS (according to modified ATP III criteria), and 37 individuals without MS as controls. ADMA levels were significantly increased in the MS group (mean +/- standard deviation 0.71 +/- 0.38 vs. 0.48 +/- 0.28 mu mol/L, p = 0.0009). Furthermore, the levels of ADMA were modestly but significantly correlated with waist circumference (p = 0.01) but not with the other components of MS (blood pressure, glycemia, triglycerides and high density lipoprotein cholesterol HDL-c). These results suggest a possible link between increased ADMA levels and the MS. (C) 2011 Elsevier Inc. All rights reserved.
C1 [Palomo, Ivan; Contreras, Alejandra; Marcelo Alarcon, L.; Leiva, Elba; Guzman, Luis; Moore-Carrasco, Rodrigo] Univ Talca, Fac Ciencias Salud, Dept Bioquim Clin & Inmunohematol, Talca, Chile.
   [Mujica, Veronica] Univ Talca, Escuela Med, Talca, Chile.
   [Icaza, Gloria; Diaz, Nora] Univ Talca, Inst Matemat & Fis, Talca, Chile.
   [Gonzalez, Daniel R.] Univ Talca, Fac Ciencias Salud, Dept Ciencias Basicas Biomed, Talca, Chile.
C3 Universidad de Talca; Universidad de Talca; Universidad de Talca;
   Universidad de Talca
RP Palomo, I (corresponding author), Univ Talca, Fac Ciencias Salud, Dept Bioquim Clin & Inmunohematol, POB 747, Talca, Chile.
EM ipalomo@utalca.cl
RI Palomo, Iván/I-4321-2018; Moore-Carrasco, Rodrigo/AAK-3349-2020;
   Alarcon, Marcelo/I-5016-2018; Contreras, Alejandra/E-7815-2013; Guzmán,
   Luis/HLH-3515-2023
OI Palomo, Ivan/0000-0002-9618-8778; Icaza, Gloria/0000-0002-3192-3428;
   Mujica, Veronica/0000-0001-6290-410X; Guzman, Luis/0000-0003-1552-7430;
   GONZALEZ, DANIEL/0000-0002-3437-8998; alarcon,
   marcelo/0000-0001-7596-5382; Moore-Carrasco, Rodrigo/0000-0003-4870-9660
FU Cardiovascular Disease Risk Factors (PIFRECV), Universidad de Talca,
   Talca, Chile
FX Supported by the Research Program of Cardiovascular Disease Risk Factors
   (PIFRECV), Universidad de Talca, Talca, Chile.
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NR 35
TC 52
Z9 53
U1 0
U2 6
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 1089-8603
EI 1089-8611
J9 NITRIC OXIDE-BIOL CH
JI Nitric Oxide-Biol. Chem.
PD MAY 31
PY 2011
VL 24
IS 4
BP 224
EP 228
DI 10.1016/j.niox.2011.03.002
PG 5
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA 775KE
UT WOS:000291457400009
PM 21419857
DA 2025-06-11
ER

PT J
AU Klisic, A
   Kotur-Stevuljevic, J
   Patoulias, D
   Ninic, A
AF Klisic, Aleksandra
   Kotur-Stevuljevic, Jelena
   Patoulias, Dimitrios
   Ninic, Ana
TI Serum Endocan Levels in Postmenopausal Women with Metabolic Syndrome
SO METABOLIC SYNDROME AND RELATED DISORDERS
LA English
DT Article
DE endothelial dysfunction; inflammation; insulin resistance; oxidative
   stress
ID ASSOCIATION; PRODUCTS
AB Aim: Studies that explored endocan (as a novel marker of endothelial dysfunction) in relation to metabolic syndrome (MetS) are scarce and show discordant results. Importantly, no study has yet examined serum endocan levels in exclusively postmenopausal women with MetS and free of diabetes. Oxidative stress and inflammation are the key features of MetS and consequently cardiovascular diseases. Hence, we aimed to explore the potential relationship between endocan, oxidative stress [i.e., determined by total antioxidant status, total oxidant status, and pro-oxidant/antioxidant balance (PAB)], inflammation, and MetS in a cohort of postmenopausal women.Methods: A total of 126 postmenopausal women were included consecutively. MetS was diagnosed following the International Diabetes Federation criteria.Results: Higher serum endocan levels were found in MetS group as compared with MetS-free counterparts [6.03 (3.47-10.37) pg/mL vs. 2.27 (1.49-3.50) pg/mL, P < 0.001]. Endocan showed good discriminatory ability toward MetS [area under the curve (AUC) = 0.809]. Besides age, the inclusion of oxidative stress and inflammation biomarkers, such as PAB and high-sensitivity C-reactive protein (hsCRP), the AUC for discrimination postmenopausal women with MetS from MetS-free women was 0.845.Conclusion: Postmenopausal women with MetS exhibited almost 2.7 times higher serum endocan level as compared with MetS-free middle-aged women. Endocan showed good discriminatory ability toward MetS and could be a diagnostic marker in MetS. Similar results were confirmed when added an age, oxidative stress, and inflammation biomarkers (i.e., PAB and hsCRP) were included for the discrimination of postmenopausal with MetS from MetS-free women.
C1 [Klisic, Aleksandra] Univ Montenegro, Fac Med, Podgorica, Montenegro.
   [Klisic, Aleksandra] Primary Hlth Care Ctr, Ctr Lab Diagnost, Podgorica, Montenegro.
   [Kotur-Stevuljevic, Jelena; Ninic, Ana] Univ Belgrade, Fac Pharm, Dept Med Biochem, Belgrade, Serbia.
   [Patoulias, Dimitrios] Aristotle Univ Thessaloniki, Gen Hosp Hippokration, Outpatient Dept Cardiometab Med, Dept Cardiol 2, Thessaloniki, Greece.
   [Klisic, Aleksandra] Univ Montenegro, Fac Med, Ctr Lab Diagnost, Primary Hlth Care Ctr, Trg Nikole Kovacev 6, Podgorica 81000, Montenegro.
C3 University of Montenegro; University of Belgrade; Aristotle University
   of Thessaloniki; University of Montenegro
RP Klisic, A (corresponding author), Univ Montenegro, Fac Med, Ctr Lab Diagnost, Primary Hlth Care Ctr, Trg Nikole Kovacev 6, Podgorica 81000, Montenegro.
EM aleksandranklisic@gmail.com
RI Patoulias, Dimitrios/AAH-8861-2019; Klisic, Aleksandra/ABC-9219-2020
OI Ninic, Ana/0000-0003-3838-1606
FU Ministry of Science and Technological Development, Montenegro; Ministry
   of Education, Science and Technological Development, Republic of Serbia
   [451-03-68/2020-14/200161]
FX This work was financially supported in part by a grant from the Ministry
   of Science and Technological Development, Montenegro and the Ministry of
   Education, Science and Technological Development, Republic of Serbia
   (project number 451-03-68/2020-14/200161).
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NR 31
TC 2
Z9 2
U1 1
U2 5
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-4196
EI 1557-8518
J9 METAB SYNDR RELAT D
JI Metab. Syndr. Relat. Disord.
PD DEC 1
PY 2023
VL 21
IS 10
BP 561
EP 566
DI 10.1089/met.2023.0119
PG 6
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA CB9K8
UT WOS:001122906700003
PM 37669459
DA 2025-06-11
ER

PT J
AU Chen, SJ
   Yen, CH
   Huang, YC
   Lee, BJ
   Hsia, S
   Lin, PT
AF Chen, Shu-Ju
   Yen, Chi-Hua
   Huang, Yi-Chia
   Lee, Bor-Jen
   Hsia, Simon
   Lin, Ping-Ting
TI Relationships between Inflammation, Adiponectin, and Oxidative Stress in
   Metabolic Syndrome
SO PLOS ONE
LA English
DT Article
ID C-REACTIVE PROTEIN; CARDIOVASCULAR-DISEASE; DIABETES-MELLITUS;
   INTERLEUKIN-6; OBESITY; PREVALENCE; HYPERTENSION; ASSOCIATION;
   POPULATION; MARKERS
AB Metabolic syndrome (MS) represents a cluster of physiological and anthropometric abnormalities. The purpose of this study was to investigate the relationships between the levels of inflammation, adiponectin, and oxidative stress in subjects with MS. The inclusion criteria for MS, according to the Taiwan Bureau of Health Promotion, Department of Health, were applied to the case group (n = 72). The control group (n = 105) comprised healthy individuals with normal blood biochemical values. The levels of inflammatory markers [high sensitivity C-reactive protein (hs-CRP) and interleukin-6 (IL-6), adiponectin, an oxidative stress marker (malondialdehyde), and antioxidant enzymes activities [catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx)] were measured. Subjects with MS had significantly higher concentrations of inflammatory markers and lower adiponectin level, and lower antioxidant enzymes activities than the control subjects. The levels of inflammatory markers and adiponectin were significantly correlated with the components of MS. The level of hs-CRP was significantly correlated with the oxidative stress marker. The IL-6 level was significantly correlated with the SOD and GPx activities, and the adiponectin level was significantly correlated with the GPx activity. A higher level of hs-CRP (>= 1.00 mg/L), or IL-6 (>= 1.50 pg/mL) or a lower level of adiponectin (<7.90 mu g/mL) were associated with a significantly greater risk of MS. In conclusion, subjects suffering from MS may have a higher inflammation status and a higher level of oxidative stress. A higher inflammation status was significantly correlated with decreases in the levels of antioxidant enzymes and adiponectin and an increase in the risk of MS.
C1 [Huang, Yi-Chia; Lee, Bor-Jen; Lin, Ping-Ting] Chung Shan Med Univ, Sch Nutr, Taichung, Taiwan.
   [Chen, Shu-Ju] Chung Chou Univ Sci & Technol, Dept Hlth Food, Changhua, Taiwan.
   [Yen, Chi-Hua] Chung Shan Med Univ Hosp, Dept Family & Community Med, Taichung, Taiwan.
   [Yen, Chi-Hua] Chung Shan Med Univ, Sch Med, Taichung, Taiwan.
   [Yen, Chi-Hua] Chung Shan Med Univ, Ctr Educ & Res Geriatr & Gerontol, Taichung, Taiwan.
   [Huang, Yi-Chia; Lin, Ping-Ting] Chung Shan Med Univ Hosp, Dept Nutr, Taichung, Taiwan.
   [Lee, Bor-Jen] Taichung Vet Gen Hosp, Intens Care Unit, Taichung, Taiwan.
   [Hsia, Simon] HungKuang Univ, Dept Nutr, Taichung, Taiwan.
   [Hsia, Simon] HungKuang Univ, Inst Biomed Nutr, Taichung, Taiwan.
C3 Chung Shan Medical University; Chung Shan Medical University; Chung Shan
   Medical University Hospital; Chung Shan Medical University; Chung Shan
   Medical University; Chung Shan Medical University; Chung Shan Medical
   University Hospital; Taichung Veterans General Hospital; Hungkuang
   University; Hungkuang University
RP Lin, PT (corresponding author), Chung Shan Med Univ, Sch Nutr, Taichung, Taiwan.
EM apt810@csmu.edu.tw
RI Huang, Yi-Chia/AAS-8877-2021; Stefanadis, Christodoulos/ABH-2232-2020
OI Stefanadis, Christodoulos/0000-0001-5974-6454; Huang,
   Yi-Chia/0000-0003-2234-4464
FU National Science Council of Taiwan [NSC 99-2320-B-040-011]
FX This study was supported by a grant from the National Science Council
   (NSC 99-2320-B-040-011) of Taiwan. The funders had no role in study
   design, data collection and analysis, decision to publish, or
   preparation of the manuscript.
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NR 30
TC 58
Z9 67
U1 0
U2 9
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD SEP 19
PY 2012
VL 7
IS 9
AR e45693
DI 10.1371/journal.pone.0045693
PG 5
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 014PP
UT WOS:000309388400121
PM 23029185
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Venturini, D
   Simao, ANC
   Scripes, NA
   Bahls, LD
   Melo, PAS
   Belinetti, FM
   Lozovoy, MAB
   Dichi, I
AF Venturini, Danielle
   Simao, Andrea N. C.
   Scripes, Nicole A.
   Bahls, Larissa D.
   Melo, Petronio A. S.
   Belinetti, Francine M.
   Lozovoy, Marcell A. B.
   Dichi, Isaias
TI Evaluation of Oxidative Stress in Overweight Subjects With or Without
   Metabolic Syndrome
SO OBESITY
LA English
DT Article
ID INSULIN-RESISTANCE; CARDIOVASCULAR-DISEASE; PROTEIN PRODUCTS; URIC-ACID;
   OBESITY; INFLAMMATION; BLOOD; IMPACT; ASSAY; RISK
AB Although oxidative stress is considered the underlying mechanism by which dysfunctional metabolism occurs in obese subjects, there are few studies on oxidative stress in overweight subjects. The objective of this study was to verify the influence of metabolic syndrome (MetS) on oxidative stress and antioxidant defense in overweight subjects. There were 123 subjects (50 in the control group and 73 in the overweight group) chosen to participate in this cross-sectional study. The control group included 50 healthy individuals with a BMI between 20 and 24.9 kg/m(2) and without MetS. The overweight group included 73 subjects with a BMI between 25 and 29.9 kg/m(2). Overweight subjects were divided into two groups: with MetS (29 subjects) and without MetS (44 subjects). Control group and overweight group subjects without MetS showed no differences in oxidative stress parameters and total antioxidant capacity (TRAP). Overweight subjects with MetS had higher hydroperoxide concentrations measured by chemiluminescence compared to the control group (P < 0.05), higher hydroperoxide and hydrogen peroxide concentrations determined by ferrous oxidation-xylenol orange assay compared to overweight subjects without MetS (P < 0.001), and higher advanced oxidation protein product (AOPP) concentrations (P < 0.001) compared to the other groups. AOPP was directly correlated with uric acid concentrations. Overweight subjects with MetS had lower TRAP concentrations compared to the control group (P < 0.001). In conclusion, this study showed that overweight subjects with MetS, in contrast to overweight subjects without MetS, have a redox imbalance characterized by increased plasma oxidation and reduced antioxidant capacity.
C1 [Venturini, Danielle; Simao, Andrea N. C.; Scripes, Nicole A.; Bahls, Larissa D.] Univ Londrina, Dept Pathol Clin Anal & Toxicol, Londrina, Brazil.
   [Melo, Petronio A. S.; Belinetti, Francine M.; Dichi, Isaias] Univ Londrina, Dept Internal Med, Londrina, Brazil.
   [Lozovoy, Marcell A. B.] Univ N Parana UNOPAR, Dept Clin Anal, Londrina, Brazil.
C3 University Norte Parana
RP Simao, ANC (corresponding author), Univ Londrina, Dept Pathol Clin Anal & Toxicol, Londrina, Brazil.
EM dcianame@yahoo.com.br
RI Venturini, Danielle/HPH-1330-2023; Simão, Andrea/AAM-4892-2021; Lozovoy,
   Marcell/AAM-4897-2021; Melo, Petronio Augusto de Souza/J-7678-2018
OI Melo, Petronio Augusto de Souza/0000-0003-0726-3172; Bahls Pinto,
   Larissa Danielle/0000-0001-6469-3123
FU Research Funds of University of Londrina (FAEPE)
FX This study was financially supported by Research Funds of University of
   Londrina (FAEPE).
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NR 33
TC 40
Z9 43
U1 0
U2 11
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1930-7381
EI 1930-739X
J9 OBESITY
JI Obesity
PD DEC
PY 2012
VL 20
IS 12
BP 2361
EP 2366
DI 10.1038/oby.2012.130
PG 6
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 045QX
UT WOS:000311713000006
PM 22592332
OA Bronze
DA 2025-06-11
ER

PT J
AU Levinger, I
   Selig, S
   Goodman, C
   Jerums, G
   Stewart, A
   Hare, DL
AF Levinger, Itamar
   Selig, Steve
   Goodman, Craig
   Jerums, George
   Stewart, Andrew
   Hare, David L.
TI RESISTANCE TRAINING IMPROVES DEPRESSIVE SYMPTOMS IN INDIVIDUALS AT HIGH
   RISK FOR TYPE 2 DIABETES
SO JOURNAL OF STRENGTH AND CONDITIONING RESEARCH
LA English
DT Article
DE cardiac depression scale; depressed mood; metabolic risk factors; weight
   training
ID QUALITY-OF-LIFE; METABOLIC SYNDROME; VALIDATION; OVERWEIGHT; EXERCISE;
   SCALE
AB Levinger, I, Selig, S, Goodman, C, Jerums, G, Stewart, A, and Hare, DL. Resistance training improves depressive symptoms in individuals at high risk for type 2 diabetes. J Strength Cond Res 25(8): 2328-2333, 2011-Depression is more prevalent in obese individuals and those with diabetes, compared to the general population. This study examined the effect of resistance training on depressed mood in individuals with high (HiMF, n >= 2) and low (LoMF, n <= 1) numbers of risk factors for metabolic syndrome and type 2 diabetes. The primary hypothesis was that resistance training would significantly reduce depressed mood, as measured by the Cardiac Depression Scale (CDS), in individuals with HiMF. Fifty-five middle-aged volunteers (50.8 +/- 0.9 years, mean +/- SEM) from the general community participated in the study. After initial allocation to HiMF or LoMF, participants were randomly allocated to 4 groups, HiMF training (HiMFT), HiMF control (HiMFC), LoMF training (LoMFT), and LoMF control (LoMFC). Participants underwent resistance training involving major muscle groups on 3 d.wk(-1) for 10 weeks. Before and after interventions (training or control), participants completed the CDS to assess change in the level of depressed mood. Following resistance training, the CDS score of the HiMFT group was reduced by -14.8 +/- 4.9 points on the CDS, a significant improvement in comparison to both baseline (p = 0.01) and HiMFC (p = 0.049) values. No significant change was observed for LoMFT. In the HiMF group only, the percent change in relative muscle strength was correlated with the Delta change in CDS; r = 20.46, p = 0.008. Resistance exercise training programs that consist 7 exercises for the major muscle groups at both low-moderate and moderate-high intensities appear to alleviate depressed mood in individuals with clusters of metabolic risk factors.
C1 [Levinger, Itamar; Selig, Steve; Goodman, Craig] Victoria Univ, Inst Sport Exercise & Act Living, Sch Sport & Exercise Sci, Melbourne, Vic 8001, Australia.
   [Jerums, George] Univ Melbourne, Dept Endocrinol, Melbourne, Vic, Australia.
   [Stewart, Andrew; Hare, David L.] Univ Melbourne, Dept Cardiol, Melbourne, Vic, Australia.
C3 Victoria University; University of Melbourne; University of Melbourne
RP Levinger, I (corresponding author), Victoria Univ, Inst Sport Exercise & Act Living, Sch Sport & Exercise Sci, Melbourne, Vic 8001, Australia.
EM itamar.levinger@vu.edu.au
RI Goodman, Craig/H-8085-2019
OI Goodman, Craig/0000-0002-5874-7743; Hare, David
   Linley/0000-0001-9554-6556; Levinger, Itamar/0000-0001-9194-2033
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NR 28
TC 15
Z9 18
U1 0
U2 25
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1064-8011
EI 1533-4287
J9 J STRENGTH COND RES
JI J. Strength Cond. Res.
PD AUG
PY 2011
VL 25
IS 8
BP 2328
EP 2333
DI 10.1519/JSC.0b013e3181f8fd4a
PG 6
WC Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Sport Sciences
GA 796PH
UT WOS:000293063500036
PM 21659891
OA Bronze
DA 2025-06-11
ER

PT J
AU McPherson, S
   Gosrani, S
   Hogg, S
   Patel, P
   Wetten, A
   Welton, R
   Hallsworth, K
   Campbell, M
AF McPherson, Stuart
   Gosrani, Shion
   Hogg, Sarah
   Patel, Preya
   Wetten, Aaron
   Welton, Rachael
   Hallsworth, Kate
   Campbell, Matthew
TI Increased cardiovascular risk and reduced quality of life are highly
   prevalent among individuals with hepatitis C
SO BMJ OPEN GASTROENTEROLOGY
LA English
DT Article
ID MANIFESTATIONS; STATINS
AB Objective Hepatitis C virus (HCV) infection is common. Although treatment is effective, with oral antivirals curing >95% of patients, most individuals have comorbidities that persist long term. Therefore, our aim was to determine the prevalence of potentially modifiable health problems in patients with HCV and develop an HCV care bundle to identify and target comorbidities.
   Design Cross-sectional, observational single-centre study that recruited consecutive patients with HCV from our viral hepatitis clinics. Data were collected on cardiovascular (CV) risk factors, lifestyle behaviours, anthropometry and health-related quality of life (HRQoL). QRISK 3 was used to predict 10-year CV event risk.
   Results 100 patients were recruited (67% male, 93% white, median age 52 years (range 24-80); 71% were treated for HCV; 34% had cirrhosis; 14% had diabetes; 61% had hypertension; 31% had metabolic syndrome; and 54% were smokers). The median 10-year CV event risk was 8.3% (range 0.3%-63%). 45% had a predicted 10-year CV event risk of >10%. Only 10% of individuals were treated with statins and 27% with antihypertensives. 92% had a predicted 'heart age' greater than their chronological age (median difference +7 (-4 to +26) years). HRQoL was reduced in all SF36v2 domains in the cohort. Factors independently associated with HRQoL included cirrhosis, metabolic syndrome, history of mental health disorder, sedentary behaviour and HCV viraemia.
   Conclusion A large proportion of patients with HCV presented with increased risk of CV events, and rates of smoking and sedentary behaviour were high, while prescribing of primary prophylaxis was infrequent. HRQoL was also reduced in the cohort. A 'care bundle' was developed to provide a structured approach to treating potentially modifiable health problems.
C1 [McPherson, Stuart; Gosrani, Shion; Hogg, Sarah; Patel, Preya; Wetten, Aaron; Welton, Rachael; Hallsworth, Kate] Newcastle Tyne Hosp NHS Fdn Trust, Liver Unit, Newcastle Upon Tyne, Tyne & Wear, England.
   [McPherson, Stuart; Hallsworth, Kate] Newcastle Univ, Translat & Clin Res Inst, Newcastle Upon Tyne, Tyne & Wear, England.
   [Campbell, Matthew] Univ Leeds, Sch Food Sci & Nutr, Leeds, W Yorkshire, England.
   [Campbell, Matthew] Univ Leeds, Leeds Inst Cardiovasc & Metab Med, Leeds, W Yorkshire, England.
C3 Newcastle Upon Tyne Hospitals NHS Foundation Trust; Newcastle University
   - UK; University of Leeds; University of Leeds
RP McPherson, S (corresponding author), Newcastle Tyne Hosp NHS Fdn Trust, Liver Unit, Newcastle Upon Tyne, Tyne & Wear, England.; McPherson, S (corresponding author), Newcastle Univ, Translat & Clin Res Inst, Newcastle Upon Tyne, Tyne & Wear, England.
EM stuart.mcpherson2@nhs.net
RI Wetten, Aaron/GZK-6848-2022; Campbell, Matthew/AAZ-2997-2021
OI McPherson, Stuart/0000-0002-5638-2453; Patel, Preya/0000-0002-2433-6794;
   Hallsworth, Kate/0000-0002-1860-6970; Campbell,
   Matthew/0000-0001-5883-5041
FU LIVErNORTH Charity
FX LIVErNORTH Charity.
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NR 42
TC 11
Z9 13
U1 0
U2 0
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2054-4774
J9 BMJ OPEN GASTROENTER
JI BMJ Open Gastroenterol.
PY 2020
VL 7
IS 1
AR e000470
DI 10.1136/bmjgast-2020-000470
PG 10
WC Gastroenterology & Hepatology
WE Emerging Sources Citation Index (ESCI)
SC Gastroenterology & Hepatology
GA QJ7NV
UT WOS:000619873900001
PM 32847899
OA Green Published, Green Accepted, gold
DA 2025-06-11
ER

PT J
AU Haam, JH
   Lee, YK
   Suh, E
   Choi, SW
   Chun, H
   Kim, YS
AF Haam, Ji-Hee
   Lee, Yun Kyong
   Suh, Eunkyung
   Choi, Sang-Woon
   Chun, Hyejin
   Kim, Young-Sang
TI Urine organic acids may be useful biomarkers for metabolic syndrome and
   its components in Korean adults
SO CLINICAL CHEMISTRY AND LABORATORY MEDICINE
LA English
DT Article
DE insulin resistance; metabolic syndrome; metabolomics; urine organic acid
ID INSULIN-RESISTANCE; BETA-HYDROXYBUTYRATE; AMINO-ACIDS; STRESS;
   DETERMINANTS; HISTIDINE; THERAPY; PATHWAY; OBESITY; PROFILE
AB Objectives: Although metabolic syndrome (MetS) and its components are defined clinically, those with MetS may have various derangements in metabolic pathways. Thus, this study aimed to evaluate the traits of urine organic acid metabolites indicating the metabolic intermediates of the pathways in the subjects with MetS.
   Methods: This cross-sectional study included 246 men and 283 women in a hospital health check-up setting. Urine organic acid metabolites were assayed via high-performance liquid chromatography-mass spectrometry analyses. A high level of each metabolite was defined as the fifth quintile of the distribution.
   Results: The subjects with MetS had high levels of pyruvate, alpha-ketoglutarate, alpha-ketoisovalerate, alpha-ketoisocaproate, formiminoglutamate, and quinolinate (odds ratios from 1.915 to 2.809 in logistic models adjusted for age and sex). Among the metabolites, pyruvate, formiminoglutamate, and quinolinate were not independent of homeostatic model assessment of insulin resistance (HOMA2-IR). Several metabolites were associated with one or more components of MetS and HOMA2-IR.
   Conclusions: Urine organic acid metabolites in MetS are characterized in altered carbohydrate and amino acid metabolism. MetS shared some traits in insulin resistance. These findings may promote the understanding of the pathophysiology of MetS.
C1 [Kim, Young-Sang] CHA Univ, Dept Family Med, CHA Bundang Med Ctr, 59 Yatap Ro, Seongnam Si 13496, Gyeonggi Do, South Korea.
   [Haam, Ji-Hee; Lee, Yun Kyong; Suh, Eunkyung; Choi, Sang-Woon] CHA Univ, Chaum Life Ctr, Seoul, South Korea.
   [Chun, Hyejin] CHA Univ, CHA Bundang Med Ctr, Dept Family Med, Seongnam, South Korea.
C3 Pochon Cha University; Pochon Cha University; Pochon Cha University
RP Kim, YS (corresponding author), CHA Univ, Dept Family Med, CHA Bundang Med Ctr, 59 Yatap Ro, Seongnam Si 13496, Gyeonggi Do, South Korea.
EM zeroup@cha.ac.kr
OI Kim, Young-Sang/0000-0002-7397-5410
FU Yuhan Co, Ltd. [2020-02-020]; Academic Fund from CHA university
FX This study was supported by Yuhan Co, Ltd. [grant number 2020-02-020]
   and Academic Fund from CHA university.
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NR 50
TC 3
Z9 3
U1 1
U2 9
PU WALTER DE GRUYTER GMBH
PI BERLIN
PA GENTHINER STRASSE 13, D-10785 BERLIN, GERMANY
SN 1434-6621
EI 1437-4331
J9 CLIN CHEM LAB MED
JI Clin. Chem. Lab. Med.
PD OCT
PY 2021
VL 59
IS 11
BP 1824
EP 1831
DI 10.1515/cclm-2021-0598
PG 8
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA UQ7LQ
UT WOS:000696242800019
PM 34331849
DA 2025-06-11
ER

PT J
AU Leisegang, K
   Henkel, R
   Agarwal, A
AF Leisegang, Kristian
   Henkel, Ralf
   Agarwal, Ashok
TI Obesity and metabolic syndrome associated with systemic inflammation and
   the impact on the male reproductive system
SO AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
LA English
DT Review
DE chronic inflammation; male infertility; metabolic syndrome; obesity;
   spermatogenesis; steroidogenesis
ID BODY-MASS INDEX; URINARY-TRACT SYMPTOMS; OXIDATIVE STRESS;
   ADIPOSE-TISSUE; SEMEN QUALITY; SEMINAL PLASMA; ERECTILE DYSFUNCTION;
   INSULIN-RESISTANCE; TNF-ALPHA; CYTOKINE CONCENTRATIONS
AB Obesity and metabolic syndrome (MetS) are global epidemics, driven by an obesogenic environment. This is mediated by complex underlying pathophysiology, in which chronic inflammation is an important aetiological and mechanistic phenomenon. A shift towards a subclinical T(H)1-lymphocyte mediated innate and chronic inflammatory response is well defined in obesity and MetS, demonstrated in multiple systems including visceral adiposity, brain (hypothalamus), muscles, vasculature, liver, pancreas, testes, epididymis, prostate and seminal fluid. Inflammatory cytokines disrupt the hypothalamic-pituitary-testes axis and steroidogenesis cascades (hypogonadotropic hypogonadism), spermatogenesis (poor semen parameters, including DNA fragmentation and detrimental epigenetic modification) and results in subclinical prostatitis and prostate hyperplasia. This review aims to highlight the role of chronic inflammation in obesity and MetS, cytokines in male reproductive physiology and pathophysiology, the impact on steroidogenesis and spermatogenesis, prostate pathology and erectile dysfunction. Currently, it is recommended that clinical assessment of male infertility and reproductive dysfunction in obese and MetS patients includes inflammation assessment (highly sensitive C-reactive protein), and appropriate advice and therapeutic options are incorporated in the management options. However, the mechanisms and therapeutic options remain poorly understood and require significant interdisciplinary research to identify potential novel therapeutic strategies.
C1 [Leisegang, Kristian] Univ Western Cape, Sch Nat Med, Blanckenberg Rd, Cape Town, South Africa.
   [Henkel, Ralf] Univ Western Cape, Dept Med Biosci, Cape Town, South Africa.
   [Henkel, Ralf; Agarwal, Ashok] Cleveland Clin, Dept Urol, Amer Ctr Reprod Med, Cleveland, OH 44106 USA.
C3 University of the Western Cape; University of the Western Cape;
   Cleveland Clinic Foundation
RP Leisegang, K (corresponding author), Univ Western Cape, Sch Nat Med, Blanckenberg Rd, Cape Town, South Africa.
EM kleisegang@uwc.ac.za
RI Leisegang, Kristian/AAS-3925-2021
OI Leisegang, Kristian/0000-0002-3003-8048; Henkel,
   Ralf/0000-0003-1128-2982
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NR 153
TC 85
Z9 91
U1 2
U2 18
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1046-7408
EI 1600-0897
J9 AM J REPROD IMMUNOL
JI Am. J. Reprod. Immunol.
PD NOV
PY 2019
VL 82
IS 5
AR e13178
DI 10.1111/aji.13178
EA AUG 2019
PG 14
WC Immunology; Reproductive Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Reproductive Biology
GA JH5YW
UT WOS:000484297900001
PM 31373727
DA 2025-06-11
ER

PT J
AU Sueta, D
   Koibuchi, N
   Hasegawa, Y
   Toyama, K
   Uekawa, K
   Katayama, T
   Ma, M
   Nakagawa, T
   Ogawa, H
   Kim-Mitsuyama, S
AF Sueta, Daisuke
   Koibuchi, Nobutaka
   Hasegawa, Yu
   Toyama, Kensuke
   Uekawa, Ken
   Katayama, Tetsuji
   Ma, MingJie
   Nakagawa, Takashi
   Ogawa, Hisao
   Kim-Mitsuyama, Shokei
TI Telmisartan Exerts Sustained Blood Pressure Control and Reduces Blood
   Pressure Variability in Metabolic Syndrome by Inhibiting Sympathetic
   Activity
SO AMERICAN JOURNAL OF HYPERTENSION
LA English
DT Article
DE angiotensin receptor blocker; blood pressure; blood pressure
   variability; hypertension; oxidative stress; sympathetic activity;
   telemetry
ID ROSTRAL VENTROLATERAL MEDULLA; TO-VISIT VARIABILITY; OXIDATIVE STRESS;
   HYPERTENSION; RECEPTOR; OBESITY; SYMPATHOINHIBITION; ACTIVATION; RATS
AB BACKGROUND
   Accumulating evidence on blood pressure (BP) reduction with various angiotensin II receptor blockers (ARBs) show that the magnitudes and durations of BP control differ across ARBs. However, the mechanism of ARBs is unknown. This work was undertaken to compare telmisartan and valsartan in duration of BP control, BP variability, and effects on the autonomic nervous system.
   METHODS
   Using radiotelemetry combined with spectral analysis with a fast Fourier transformation algorithm, we compared the effects of various doses of telmisartan and valsartan on BP and its variability during dark (active phase) and light (inactive phase) periods over 5 weeks in SHR/NDmcr-cp(+/+)(SHRcp) rats, a model of metabolic syndrome. We also compared the effects of these ARBs on autonomic nervous system, central oxidative stress, and inflammation in SHRcp rats.
   RESULTS
   Telmisartan exerted a longer-lasting BP-lowering effect and greater attenuation of BP variability in SHRcp than valsartan. Telmisartan decreased low frequency power of systolic BP and increased spontaneous baroreflex gain in SHRcp during both the dark and light periods more than valsartan. Telmisartan reduced 24-hour urinary norepinephrine excretion more than valsartan. Furthermore, telmisartan attenuated oxidative stress and the numbers of gp91(phox)-positive cells and activated microglia and astrocytes in the rostral ventrolateral medulla of SHRcp rats more than valsartan.
   CONCLUSIONS
   The superiority of telmisartan over valsartan in sustained BP control and reduction of BP variability was attributed to more suppression of sympathetic activity and more improvement of baroreceptor reflex. The greater suppression of sympathetic activity by telmisartan appeared to be partially mediated by a stronger amelioration of central oxidative stress.
C1 [Sueta, Daisuke; Koibuchi, Nobutaka; Hasegawa, Yu; Toyama, Kensuke; Uekawa, Ken; Katayama, Tetsuji; Ma, MingJie; Nakagawa, Takashi; Kim-Mitsuyama, Shokei] Kumamoto Univ, Grad Sch Med Sci, Dept Pharmacol & Mol Therapeut, Kumamoto, Japan.
   [Ogawa, Hisao] Kumamoto Univ, Grad Sch Med Sci, Dept Cardiovasc Med, Kumamoto, Japan.
C3 Kumamoto University; Kumamoto University
RP Kim-Mitsuyama, S (corresponding author), Kumamoto Univ, Grad Sch Med Sci, Dept Pharmacol & Mol Therapeut, Kumamoto, Japan.
EM mitsuyam@gpo.kumamoto-u.ac.jp
RI Sueta, Daisuke/ABG-9809-2021; Nakagawa, Takashi/F-3015-2010; Uekawa,
   Ken/LEM-7766-2024
FU Astellas; AstraZeneca; Bayer; Boehringer Ingelheim; Chugai; Daiichi
   Sankyo; Dainippon Sumitomo Pharma; Eisai; Kowa; Kyowa Hakko Kirin;
   Mitsubishi Tanabe; MSD; Novartis; Otsuka; Pfizer; Sanofi; Sionogi;
   Takeda
FX H.O. received lecture fees and research grant from Astellas,
   AstraZeneca, Bayer, Boehringer Ingelheim, Chugai, Daiichi Sankyo,
   Dainippon Sumitomo Pharma, Eisai, Kowa, Kyowa Hakko Kirin, Mitsubishi
   Tanabe, MSD, Novartis, Otsuka, Pfizer, Sanofi, Sionogi, and Takeda.
   S.K.-M. received lecture fees and research grant from Astellas,
   AstraZeneca, Boehringer Ingelheim, Daiichi Sankyo, Novartis, Sionogi,
   Takeda, and Kyowa Hakko Kirin.
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NR 34
TC 23
Z9 23
U1 0
U2 2
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0895-7061
EI 1941-7225
J9 AM J HYPERTENS
JI Am. J. Hypertens.
PD DEC
PY 2014
VL 27
IS 12
BP 1464
EP 1471
DI 10.1093/ajh/hpu076
PG 8
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA AU7LM
UT WOS:000345782100005
PM 24871627
OA Bronze
DA 2025-06-11
ER

PT J
AU Ittichaicharoen, J
   Apaijai, N
   Tanajak, P
   Sa-nguanmoo, P
   Chattipakorn, N
   Chattipakorn, S
AF Ittichaicharoen, Jitjiroj
   Apaijai, Nattayaporn
   Tanajak, Pongpan
   Sa-nguanmoo, Piangkwan
   Chattipakorn, Nipon
   Chattipakorn, Siriporn
TI Dipeptidyl peptidase-4 inhibitor enhances restoration of salivary glands
   impaired by obese-insulin resistance
SO ARCHIVES OF ORAL BIOLOGY
LA English
DT Article
DE Insulin; Obesity; Metabolic syndrome; Salivary gland function;
   Mitochondria; DPP-IV inhibitor; Vildagliptin
ID HIGH-FAT DIET; BRAIN MITOCHONDRIAL-FUNCTION; OXIDATIVE STRESS; METABOLIC
   SYNDROME; DIABETES-MELLITUS; RECEPTOR FUNCTION; EPITHELIAL-CELLS; DPP-4
   INHIBITOR; RATS; VILDAGLIPTIN
AB Objective: Chronic high-fat diet consumption causes not only obese- insulin resistance, but also leads to pathological changes in salivary glands, including increased mitochondrial dysfunction, apoptosis, oxidative stress, and inflammation. Dipeptidyl peptidase-4 inhibitor (vildagliptin) is an oral anti-diabetic drug, using for treatment of type 2 diabetes. Vildagliptin has been shown to exert beneficial effects on several organs in cases of obese-insulin resistant condition. However, the effect of vildagliptin on salivary glands impaired by obese-insulin resistance has not been investigated. The hypothesis in this study is that vildagliptin confers beneficial effects on the salivary gland impaired by obese-insulin resistance via decreasing mitochondrial dysfunction, apoptosis, oxidative stress, and inflammation.
   Design: Twenty-four male Wistar rats were divided into two groups. Each group was fed with either a normal (ND; n = 8) or a high fat diet (HFD; n = 16) for 16 weeks. At week 13, the HFD-fed rats were subdivided into 2 subgroups to receive either a vehicle or vildagliptin (3 mg/kg/day) for 28 days via gavage feeding. ND-fed rats were treated with the vehicle. At the end of treatment, metabolic parameters were examined, and rats were killed. Submandibular glands were removed to appraise inflammatory markers, apoptosis and mitochondrial function.
   Results: Vehicle-treated HFD-fed rats developed obese-insulin resistance with an increase in oxidative stress, inflammation, apoptosis, and mitochondrial dysfunction in the salivary glands. Vildagliptin therapy reduced oxidative stress, inflammation, apoptosis and mitochondrial dysfunction in salivary gland of HFD-fed rats.
   Conclusion: Vildagliptin prevented salivary gland injury occurring due to obese-insulin resistance.
C1 [Ittichaicharoen, Jitjiroj; Chattipakorn, Siriporn] Chiang Mai Univ, Fac Dent, Dept Oral Biol & Diagnost Sci, Chiang Mai 50200, Thailand.
   [Ittichaicharoen, Jitjiroj; Apaijai, Nattayaporn; Tanajak, Pongpan; Sa-nguanmoo, Piangkwan; Chattipakorn, Nipon; Chattipakorn, Siriporn] Chiang Mai Univ, Fac Med, Cardiac Electrophysiol Res & Training Ctr, Neurophysiol Unit, Chiang Mai 50200, Thailand.
   [Apaijai, Nattayaporn; Tanajak, Pongpan; Sa-nguanmoo, Piangkwan; Chattipakorn, Nipon] Chiang Mai Univ, Fac Med, Dept Physiol, Cardiac Electrophysiol Unit, Chiang Mai 50200, Thailand.
   [Ittichaicharoen, Jitjiroj; Apaijai, Nattayaporn; Tanajak, Pongpan; Sa-nguanmoo, Piangkwan; Chattipakorn, Nipon; Chattipakorn, Siriporn] Chiang Mai Univ, Ctr Excellence Cardiac Electrophysiol Res, Chiang Mai 50200, Thailand.
C3 Chiang Mai University; Chiang Mai University; Chiang Mai University;
   Chiang Mai University
RP Chattipakorn, S (corresponding author), Chiang Mai Univ, Fac Dent, Dept Oral Biol & Diagnost Sci, Chiang Mai 50200, Thailand.; Chattipakorn, S (corresponding author), Chiang Mai Univ, Fac Med, Cardiac Electrophysiol Res & Training Ctr, Neurophysiol Unit, Chiang Mai 50200, Thailand.
EM scchattipakorn@gmail.com
RI Chattipakorn, Nipon/AAJ-4049-2021; Tanajak, Pongpan/ABB-2347-2020
OI Chattipakorn, Nipon/0000-0003-3026-718X; Sa-nguanmoo,
   Piangkwan/0000-0002-4795-8473; Chattipakorn,
   Siriporn/0000-0003-1677-7052
FU Thailand Research Fund grants [TRF-RTA 6080003]; National Research
   Council of Thailand; CMU50th Anniversary grant by Chiang Mai University
   [PHD/021/2556]; NSTDA Research Chair Grant from the National Science and
   Technology Development Agency Thailand; Chiang Mai University Center of
   Excellence Award
FX This work was supported by Thailand Research Fund grants: TRF-RTA
   6080003 (SCC); the National Research Council of Thailand (SCC); a
   CMU50th Anniversary grant by Chiang Mai University (PHD/021/2556 JI &
   SCC); a NSTDA Research Chair Grant from the National Science and
   Technology Development Agency Thailand (NC) and a Chiang Mai University
   Center of Excellence Award (NC). The authors would like to thank Ms.
   Maria Love for her editorial assistance.
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NR 34
TC 6
Z9 6
U1 0
U2 45
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0003-9969
EI 1879-1506
J9 ARCH ORAL BIOL
JI Arch. Oral Biol.
PD JAN
PY 2018
VL 85
BP 148
EP 153
DI 10.1016/j.archoralbio.2017.10.015
PG 6
WC Dentistry, Oral Surgery & Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dentistry, Oral Surgery & Medicine
GA FR3QY
UT WOS:000418982400019
PM 29073562
DA 2025-06-11
ER

PT J
AU Perez-Cornago, A
   Sanchez-Villegas, A
   Bes-Rastrollo, M
   Gea, A
   Molero, P
   Lahortiga-Ramos, F
   Martinez-Gonzalez, MA
AF Perez-Cornago, Aurora
   Sanchez-Villegas, Almudena
   Bes-Rastrollo, Maira
   Gea, Alfredo
   Molero, Patricio
   Lahortiga-Ramos, Francisca
   Angel Martinez-Gonzalez, Miguel
TI Relationship between adherence to Dietary Approaches to Stop
   Hypertension (DASH) diet indices and incidence of depression during up
   to 8 years of follow-up
SO PUBLIC HEALTH NUTRITION
LA English
DT Article
DE DASH; Depression; Dietary pattern; SUN cohort; Mood
ID SEGUIMIENTO-UNIVERSIDAD; METABOLIC SYNDROME; ASSOCIATION; RISK;
   METAANALYSIS; PATTERN; CORTISOL; DISEASE; QUALITY; SCORES
AB Objective: Our aim was to evaluate the relationship between adherence to different Dietary Approaches to Stop Hypertension (DASH) diet indices and the risk of depression.
   Design: In a prospective study we assessed 14051 participants of a dynamic (permanently ongoing recruitment) prospective cohort (the Seguimiento Universidad de Navarra (SUN) Project), initially free of depression. At baseline, a validated FFQ was used to assess adherence to four previously proposed DASH indices (Dixon, Mellen, Fung and Gunther). To define the outcome we applied two definitions of depression: a less conservative definition including only self-reported physician-diagnosed depression (410 incident cases) and a more conservative definition that required both clinical diagnosis of depression and use of antidepressants (113 incident cases). Cox regression and restricted cubic splines analyses were performed.
   Results: After a median follow-up period of 8 years, the multiple-adjusted model showed an inverse association with the Fung DASH score (hazard ratio (HR)=076; 95 % CI 061, 094) when we used the less conservative definition of depression, and also under the more conservative definition (HR=063; 95 % CI 041, 095). We observed a weak inverse association with the Mellen DASH score, but no statistically significant association was found for the other definitions. The restricted cubic splines analyses suggested that these associations were non-linear (U-shaped).
   Conclusions: Moderate adherence to the DASH diet as operationalized by Fung and Mellen was related to lower depression risk. Since these associations were non-linear, additional prospective studies are required before the results can be generalized and clinical recommendations can be given.
C1 [Perez-Cornago, Aurora; Bes-Rastrollo, Maira; Gea, Alfredo; Angel Martinez-Gonzalez, Miguel] Univ Navarra, Dept Prevent Med & Publ Hlth, C Irunlarrea 1, Pamplona 31008, Spain.
   [Sanchez-Villegas, Almudena] Univ Las Palmas Gran Canaria, Dept Clin Sci, Las Palmas Gran Canaria, Spain.
   [Sanchez-Villegas, Almudena; Bes-Rastrollo, Maira; Gea, Alfredo; Angel Martinez-Gonzalez, Miguel] Inst Hlth Carlos III, Biomed Res Ctr Network Obes & Nutr CIBERobn, Physiopathol Obes & Nutr, Madrid, Spain.
   [Molero, Patricio; Lahortiga-Ramos, Francisca] Univ Clin Navarra, Dept Psychiat & Med Psychol, Pamplona, Spain.
C3 University of Navarra; Universidad de Las Palmas de Gran Canaria; CIBER
   - Centro de Investigacion Biomedica en Red; CIBEROBN; University of
   Navarra
RP Martinez-Gonzalez, MA (corresponding author), Univ Navarra, Dept Prevent Med & Publ Hlth, C Irunlarrea 1, Pamplona 31008, Spain.; Martinez-Gonzalez, MA (corresponding author), Inst Hlth Carlos III, Biomed Res Ctr Network Obes & Nutr CIBERobn, Physiopathol Obes & Nutr, Madrid, Spain.
EM mamartinez@unav.es
RI Sanchez-Villegas, Almudena/T-6733-2019; Martinez-Gonzalez,
   Miguel/AAE-7669-2019; Abad-Gurumeta, Alfredo/M-2337-2019;
   Lahortiga-Ramos, Francisca/H-9363-2017; BES-RASTROLLO,
   MAIRA/A-1329-2009; Perez-Cornago, Aurora/C-1097-2016; Molero,
   Patricio/K-8834-2013
OI Gea, Alfredo/0000-0002-2229-4690; Martinez-Gonzalez, Miguel
   A./0000-0002-3917-9808; Lahortiga-Ramos, Francisca/0000-0001-7624-6902;
   BES-RASTROLLO, MAIRA/0000-0002-9139-4206; Sanchez Villegas,
   Almudena/0000-0001-7733-9238; Perez-Cornago, Aurora/0000-0002-5652-356X;
   Molero, Patricio/0000-0002-9287-9635
FU Spanish Ministry of Health; European Regional Development Fund (FEDER)
   [PI01/0619, PI030678, PI040233, PI042241, PI050976, PI070240, PI070312,
   PI081943, PI080819, PI1002658, PI1002293, RD06/0045, 2010/087, G03/140];
   Navarra Regional Government [45/2011, 122/2014]; University of Navarra
FX This study was supported by the Spanish Ministry of Health and European
   Regional Development Fund (FEDER; grant numbers PI01/0619, PI030678,
   PI040233, PI042241, PI050976, PI070240, PI070312, PI081943, PI080819,
   PI1002658, PI1002293, RD06/0045, 2010/087 and G03/140), the Navarra
   Regional Government (grant numbers 45/2011 and 122/2014), and the
   University of Navarra. The funders had no role in the design, analysis
   or writing of this article.
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NR 36
TC 45
Z9 47
U1 0
U2 4
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 1368-9800
EI 1475-2727
J9 PUBLIC HEALTH NUTR
JI Public Health Nutr.
PD SEP
PY 2017
VL 20
IS 13
BP 2383
EP 2392
DI 10.1017/S1368980016001531
PG 10
WC Public, Environmental & Occupational Health; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health; Nutrition & Dietetics
GA FN5EN
UT WOS:000416029500013
PM 27335121
OA Green Submitted, Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Warmbrunn, MV
   Koopen, AM
   De Clercq, NC
   De Groot, PF
   Kootte, RS
   Bouter, KEC
   Ter Horst, KW
   Hartstra, AV
   Serlie, MJ
   Ackermans, MT
   Soeters, MR
   Van Raalte, DH
   Davids, M
   Nieuwdorp, M
   Groen, AK
AF Warmbrunn, Moritz, V
   Koopen, Annefleur M.
   de Clercq, Nicolien C.
   de Groot, Pieter F.
   Kootte, Ruud S.
   Bouter, Kristien E. C.
   ter Horst, Kasper W.
   Hartstra, Annick, V
   Serlie, Mireille J.
   Ackermans, Mariette T.
   Soeters, Maarten R.
   van Raalte, Daniel H.
   Davids, Mark
   Nieuwdorp, Max
   Groen, Albert K.
TI Metabolite Profile of Treatment-Naive Metabolic Syndrome Subjects in
   Relation to Cardiovascular Disease Risk
SO METABOLITES
LA English
DT Article
DE metabolic syndrome; metabolomics; cardiovascular disease; lipolysis;
   phospholipids
ID INSULIN-RESISTANCE; GLUCOSE; ACYLCARNITINES; OBESITY;
   PHOSPHATIDYLCHOLINE; INDIVIDUALS; MICROBIOTA; STRESS
AB Metabolic syndrome (MetSyn) is an important risk factor for type 2 diabetes and cardiovascular diseases (CVD). This study aimed to find distinct plasma metabolite profiles between insulin-resistant and non-insulin resistant subjects with MetSyn and evaluate if MetSyn metabolite profiles are related to CVD risk and lipid fluxes. In a cross-sectional study, untargeted metabolomics of treatment-naive males with MetSyn (n = 132) were analyzed together with clinical parameters. In a subset of MetSyn participants, CVD risk was calculated using the Framingham score (n = 111), and lipolysis (n = 39) was measured by a two-step hyperinsulinemic euglycemic clamp using [1,1,2,3,3-(2)H5] glycerol to calculate lipolysis suppression rates. Peripheral insulin resistance was related to fatty acid metabolism and glycerolphosphorylcholine. Interestingly, although insulin resistance is considered to be a risk factor for CVD, we observed that there was little correspondence between metabolites associated with insulin resistance and metabolites associated with CVD risk. The latter mainly belonged to the androgenic steroid, fatty acid, phosphatidylethanolamine, and phophatidylcholine pathways. These data provide new insights into metabolic changes in mild MetSyn pathophysiology and MetSyn CVD risk related to lipid metabolism. Prospective studies may focus on the pathophysiological role of the here-identified biomarkers.
C1 [Warmbrunn, Moritz, V; Koopen, Annefleur M.; de Clercq, Nicolien C.; de Groot, Pieter F.; Kootte, Ruud S.; Bouter, Kristien E. C.; Hartstra, Annick, V; Davids, Mark; Nieuwdorp, Max; Groen, Albert K.] Amsterdam Univ Med Ctr, Dept Internal & Vasc Med, Locat AMC, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands.
   [ter Horst, Kasper W.; Serlie, Mireille J.; Ackermans, Mariette T.; Soeters, Maarten R.] Univ Amsterdam, Dept Endocrinol & Metab, Amsterdam UMC, Locat AMC, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands.
   [van Raalte, Daniel H.] Vrije Univ Amsterdam Med Ctr, Diabet Ctr, Dept Internal Med, Amsterdam UMC,Locat VUMC, De Boelelaan 1117, NL-1081 HV Amsterdam, Netherlands.
   [van Raalte, Daniel H.] Vrije Univ Amsterdam, Amsterdam Cardiovasc Sci, Amsterdam UMC, De Boelelaan 1117, NL-1081 HV Amsterdam, Netherlands.
   [Nieuwdorp, Max] Univ Gothenburg, Wallenberg Lab, Bruna Straket 16, SE-41345 Gothenburg, Sweden.
C3 University of Amsterdam; Vrije Universiteit Amsterdam; VU UNIVERSITY
   MEDICAL CENTER; Vrije Universiteit Amsterdam; University of Gothenburg
RP Warmbrunn, MV; Groen, AK (corresponding author), Amsterdam Univ Med Ctr, Dept Internal & Vasc Med, Locat AMC, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands.
EM m.v.warmbrunn@amsterdamumc.nl; a.m.koopen@amsterdamumc.nl;
   n.c.declercq@amsterdamumc.nl; p.f.degroot@amsterdamumc.nl;
   r.s.kootte@amsterdamumc.nl; k.e.bouter@amsterdamumc.nl;
   k.w.terhorst@amsterdamumc.n1; a.v.hartstra@amsterdamumc.nl;
   mj.serlie@amsterdamumc.nl; m.t.ackermans@amsterdamumc.nl;
   m.r.soeters@amsterdamumc.nl; d.vanraalte@amsterdamumc.nl;
   m.davids@amsterdamumc.nl; m.nieuwdorp@amsterdamumc.nl;
   a.k.groen@amsterdamumc.nl
OI van Raalte, Daniel/0000-0003-2894-6124; de Clercq,
   Nicolien/0000-0002-9924-7171; Davids, Mark/0000-0003-3081-9124;
   Warmbrunn, Moritz Valerian/0000-0003-3548-6728
FU CVON In Control II [2018.27]; ZONMW VIDI grant 2013 [016.146.327]
FX M.V.W. is supported by CVON In Control II (grant number 2018.27). M.N.
   is supported by a ZONMW VIDI grant 2013 (016.146.327).
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NR 44
TC 8
Z9 8
U1 0
U2 4
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2218-1989
J9 METABOLITES
JI Metabolites
PD APR
PY 2021
VL 11
IS 4
AR 236
DI 10.3390/metabo11040236
PG 11
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA RR7MO
UT WOS:000643277900001
PM 33924347
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Usal, M
   Regnault, C
   Veyrenc, S
   Couturier, K
   Batandier, C
   Bulteau, AL
   Lejon, D
   Combourieu, B
   Lafond, T
   Raveton, M
   Reynaud, S
AF Usal, Marie
   Regnault, Christophe
   Veyrenc, Sylvie
   Couturier, Karine
   Batandier, Cecile
   Bulteau, Anne-Laure
   Lejon, David
   Combourieu, Bruno
   Lafond, Thomas
   Raveton, Muriel
   Reynaud, Stephane
TI Concomitant exposure to benzo[a]pyrene and triclosan at environmentally
   relevant concentrations induces metabolic syndrome with
   multigenerational consequences in Silurana (Xenopus) tropicalis
SO SCIENCE OF THE TOTAL ENVIRONMENT
LA English
DT Article
DE Endocrine disruptors; Metabolic syndrome; Amphibian populatiot ectine;
   Transgenerational; Silurana (Xeriopus`) tropicalis
ID NONALCOHOLIC FATTY LIVER; BISPHENOL-A EXPOSURE; ENDOCRINE-DISRUPTING
   COMPOUNDS; HEPATIC STEATOSIS; INSULIN-RESISTANCE; OXIDATIVE STRESS;
   MITOCHONDRIAL DYSFUNCTION; AROMATIC-HYDROCARBONS; REPRODUCTIVE-BIOLOGY;
   LIPID-METABOLISM
AB Numerous studies suggest that amphibians are highly sensitive to endocrine disruptors (ED) but their precise role in population decline remains unknown. This study shows that frogs exposed to a mixture of ED throughout their life cycle, at environmentally relevant concentrations, developed an unexpected metabolic syndrome. female Silurana (Xenopus) tropicalis exposed to a mixture of benzo[alpyrene and triclosan (50 ng"L each) from the tadpole stage developed liver steatosis and transcriptomic signature associated with glucose intolerance syndrome, and pancreatic insulin hyper secretion typical of pre -diabetes. These metabolic disorders were associated with delayed! metamorphosis and developmental mortality in their progeny, both of which have been linked to reduced adult recruitment and reproductive success. Indeed, Fl females were smaller and lighter and presented reduced reproductive capacities, demonstrating a reduced fitness of ED -exposed Xenopus. Our results confirm that amphibians are highly sensitive to ED even at concentrations considered to be safe for other animals. This study demonstrates that ED might be considered as direct contributing factors to amphibian population decline, due to their disruption of energetic metabolism. C 2019 Elsevier 13.V. All rights reserved.
C1 [Usal, Marie; Regnault, Christophe; Veyrenc, Sylvie; Raveton, Muriel; Reynaud, Stephane] Univ Savoie Mt Blanc, Univ Grenoble Alpes, CNRS, LECA, F-38000 Grenoble, France.
   [Couturier, Karine; Batandier, Cecile] Univ Grenoble Alpes, INSERM, LBFA, F-38000 Grenoble, France.
   [Bulteau, Anne-Laure] Univ Lyon 1, Ecole Normale Super Lyon, CNRS, Inst Genom Fonct Lyon,UMR5242, F-69000 Lyon, France.
   [Lejon, David; Combourieu, Bruno] Rovaltain Res Co, F-26300 Alixan, France.
   [Lafond, Thomas] Univ Rennes 1, CNRS, Ctr Ressources Biol Xenopes, UMS 3387, Rennes, France.
C3 Communaute Universite Grenoble Alpes; Universite Grenoble Alpes (UGA);
   Centre National de la Recherche Scientifique (CNRS); Universite Savoie
   Mont Blanc; Institut National de la Sante et de la Recherche Medicale
   (Inserm); Communaute Universite Grenoble Alpes; Universite Grenoble
   Alpes (UGA); Centre National de la Recherche Scientifique (CNRS); CNRS -
   National Institute for Biology (INSB); CHU Lyon; Ecole Normale
   Superieure de Lyon (ENS de LYON); Universite Claude Bernard Lyon 1;
   Universite de Rennes; Centre National de la Recherche Scientifique
   (CNRS)
RP Reynaud, S (corresponding author), Univ Savoie Mt Blanc, Univ Grenoble Alpes, CNRS, LECA, F-38000 Grenoble, France.
EM sylvie.veyrenc@univ-grenoble-alpes.fr;
   karine.couturier@univ-grenoble-alpes.fr;
   cecile.batandier@univ-grenoble-alpes.fr; anne-laure.bulteau@ens-lyon.fr;
   dlejon@rovaltainresearch.com; Bruno.combourieu@rovaltainresearch.com;
   thomas.lafond@univ-rennes1.fr; muriel.raveton@univ-grenoble-alpes.fr;
   stephane.reynaud@univ-grenoble-alpes.fr
RI bulteau, anne-laure/AAN-4004-2020; Raveton, Muriel/K-1403-2013; Reynaud,
   Stephane/H-5493-2013
OI veyrenc, sylvie/0000-0003-2894-3820; Reynaud,
   Stephane/0000-0003-0248-0602
FU ComUE Universite Grenoble-Alpes IRS IDEX; CNRS-INSU EC2CO program;
   Federative Structure Environmental and Systems Biology (BEeSy) of the
   Grenoble-Alpes University; French Ministry of Higher Education and
   Research; Region Auvergne-Rhone-Alpes
FX This work was funded by the ComUE Universite Grenoble-Alpes IRS IDEX
   Grant, by the CNRS-INSU EC2CO program and by the Federative Structure
   Environmental and Systems Biology (BEeSy) of the Grenoble-Alpes
   University. Marie Usal was funded by the Region Auvergne-Rhone-Alpes.
   Christophe Regnault received funding from the French Ministry of Higher
   Education and Research. We thank Kim Barrett (Version Originale) for the
   English review of the manuscript.
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NR 102
TC 13
Z9 14
U1 0
U2 46
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0048-9697
EI 1879-1026
J9 SCI TOTAL ENVIRON
JI Sci. Total Environ.
PD NOV 1
PY 2019
VL 689
BP 149
EP 159
DI 10.1016/j.scitotenv.2019.06.386
PG 11
WC Environmental Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology
GA IS8DP
UT WOS:000482379400015
PM 31271984
OA Green Accepted, Green Submitted, Bronze
DA 2025-06-11
ER

PT J
AU Vecoli, C
   Caselli, C
   Modena, M
   Todiere, G
   Poddighe, R
   Valente, S
   Bandini, F
   Natali, A
   Ghiadoni, L
   Clerico, A
   Prontera, C
   Vittorini, S
   Botto, N
   Emdin, M
   Neglia, D
AF Vecoli, Cecilia
   Caselli, Chiara
   Modena, Martina
   Todiere, Giancarlo
   Poddighe, Rosa
   Valente, Serafina
   Bandini, Fabrizio
   Natali, Andrea
   Ghiadoni, Lorenzo
   Clerico, Aldo
   Prontera, Concetta
   Vittorini, Simona
   Botto, Nicoletta
   Emdin, Michele
   Neglia, Danilo
TI Low HDL cholesterol and the eNOS Glu298Asp polymorphism are associated
   with inducible myocardial ischemia in patients with suspected stable
   coronary artery disease
SO BMC CARDIOVASCULAR DISORDERS
LA English
DT Article
DE Endothelial dysfunction; Endothelial nitric oxide synthase; eNOS; Single
   nucleotide polymorphism; Obstructive coronary artery disease; Inducible
   myocardial ischemia
ID OXIDE SYNTHASE GENE; NITRIC-OXIDE; INSULIN-RESISTANCE; HEART-DISEASE;
   GLOBAL BURDEN; RISK; OBESITY; MICROCIRCULATION; PATHOPHYSIOLOGY;
   MANAGEMENT
AB BackgroundThe endothelial nitric oxide synthase (eNOS) gene deficiency is known to cause impaired coronary vasodilating capability in animal models. In the general clinical population, the eNOS gene polymorphisms, able to affect eNOS activity, were associated with cardiometabolic risk features and prevalence of coronary artery disease (CAD).AimTo investigate the association of eNOS Glu298Asp gene polymorphism, cardiometabolic profile, obstructive CAD and inducible myocardial ischemia in patients with suspected stable CAD.MethodsA total of 506 patients (314 males; mean age 62 +/- 9 years) referred for suspected CAD was enrolled. Among these, 325 patients underwent stress ECG or cardiac imaging to assess the presence of inducible myocardial ischemia and 436 patients underwent non-invasive computerized tomography or invasive coronary angiography to assess the presence of obstructive CAD. Clinical characteristics and blood samples were collected for each patient.ResultsIn the whole population, 49.6% of patients were homozygous for the Glu298 genotype (Glu/Glu), 40.9% heterozygotes (Glu/Asp) and 9.5% homozygous for the 298Asp genotype (Asp/Asp). Obstructive CAD was documented in 178/436 (40.8%) patients undergoing coronary angiography while myocardial ischemia in 160/325 (49.2%) patients undergoing stress testing. Patients with eNOS Asp genotype (Glu/Asp + Asp/Asp) had no significant differences in clinical risk factors and in circulating markers. Independent predictors of obstructive CAD were age, gender, obesity, and low HDL-C. Independent predictors of myocardial ischemia were gender, obesity, low HDL-C and Asp genotype. In the subpopulation in which both stress tests and coronary angiography were performed, the Asp genotype remained associated with increased myocardial ischemia risk after adjustment for obstructive CAD.ConclusionIn this population, low-HDL cholesterol was the only cardiometabolic risk determinant of obstructive CAD. The eNOS Glu298Asp gene polymorphism was significantly associated with inducible myocardial ischemia independently of other risk factors and presence of obstructive CAD.
C1 [Vecoli, Cecilia; Caselli, Chiara] Inst Clin Physiol, CNR, Via G Moruzzi 1, Pisa, Italy.
   [Vecoli, Cecilia; Caselli, Chiara; Todiere, Giancarlo; Clerico, Aldo; Prontera, Concetta; Vittorini, Simona; Botto, Nicoletta; Emdin, Michele; Neglia, Danilo] Gabriele Monasterio Fdn, Cardiovasc Dept, Via G Moruzzi 1, Pisa, Italy.
   [Modena, Martina; Emdin, Michele; Neglia, Danilo] St Anna Sch Adv Studies, Pisa, Italy.
   [Poddighe, Rosa] Osped Versilia, Lucca, Italy.
   [Valente, Serafina] Careggi Univ Hosp AOUC, Florence, Italy.
   [Bandini, Fabrizio] Az Sanitaria Firenze, Florence, Italy.
   [Natali, Andrea; Ghiadoni, Lorenzo] Univ Pisa, Dept Clin & Expt Med, Pisa, Italy.
C3 Consiglio Nazionale delle Ricerche (CNR); Istituto di Fisiologia Clinica
   (IFC-CNR); Scuola Superiore Sant'Anna; Ospedale Versilia; University of
   Florence; Azienda Ospedaliero Universitaria Careggi; University of Pisa
RP Vecoli, C (corresponding author), Inst Clin Physiol, CNR, Via G Moruzzi 1, Pisa, Italy.; Vecoli, C; Neglia, D (corresponding author), Gabriele Monasterio Fdn, Cardiovasc Dept, Via G Moruzzi 1, Pisa, Italy.; Neglia, D (corresponding author), St Anna Sch Adv Studies, Pisa, Italy.
EM cecilia.vecoli@cnr.it; dneglia@ftgm.it
RI Neglia, Danilo/AAR-6384-2020; clerico, aldo/JXN-8816-2024; Emdin,
   Michele/AAC-6465-2022; Modena, Mario/AAF-3997-2019; Vecoli,
   Cecilia/K-8613-2016; Ghiadoni, Lorenzo/AAC-5176-2022; Caselli,
   Chiara/I-7922-2014
OI Ghiadoni, Lorenzo/0000-0002-7399-2720; Caselli,
   Chiara/0000-0001-6705-2460
FU Grant of the "Regional Health Research Program 2009" from the Regione
   Toscana, Italy
FX This study was supported by a Grant of the "Regional Health Research
   Program 2009" from the Regione Toscana, Italy.
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NR 46
TC 2
Z9 2
U1 0
U2 2
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1471-2261
J9 BMC CARDIOVASC DISOR
JI BMC Cardiovasc. Disord.
PD MAR 22
PY 2024
VL 24
IS 1
AR 176
DI 10.1186/s12872-024-03846-7
PG 11
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA LU6Y4
UT WOS:001189365900002
PM 38519897
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Oteri, V
   Galeano, F
   Panebianco, S
   Piticchio, T
   Le Moli, R
   Frittitta, L
   Vella, V
   Baratta, R
   Gullo, D
   Frasca, F
   Tumminia, A
AF Oteri, Vittorio
   Galeano, Francesco
   Panebianco, Stefania
   Piticchio, Tommaso
   Le Moli, Rosario
   Frittitta, Lucia
   Vella, Veronica
   Baratta, Roberto
   Gullo, Damiano
   Frasca, Francesco
   Tumminia, Andrea
TI Influence of Mediterranean Diet on Sexual Function in People with
   Metabolic Syndrome: A Narrative Review
SO NUTRIENTS
LA English
DT Review
DE metabolic syndrome; sexual function; Mediterranean diet; erectile
   dysfunction; libido; infertility; menstrual cycle; oxidative stress;
   obesity; metabolism
ID POLYCYSTIC-OVARY-SYNDROME; URINARY-TRACT SYMPTOMS; WESTERN-STYLE DIET;
   LOW-ENERGY DIET; REPRODUCTIVE FUNCTION; ERECTILE DYSFUNCTION;
   INSULIN-RESISTANCE; UNITED-STATES; SEMEN QUALITY; FATTY-ACIDS
AB Metabolic syndrome (MS), a cluster of cardiometabolic disorders, and sexual dysfunction are two conditions that impact a large proportion of the general population. Although they can occur independently, they are frequently linked and significantly affect people's quality of life. In recent years, research has increasingly focused on the importance of diet, particularly the Mediterranean diet (MD), in modulating sexual function due to its anti-inflammatory, antioxidant, and vasodilatory properties. In this narrative review, we examined the relationship between MS and sexual function in both men and women, with a special emphasis on the MD's therapeutic efficacy in improving sexual dysfunction. In men, MD has been shown to ameliorate erectile dysfunction, as well as several sperm parameters, perhaps leading to improved fertility. On the other hand, adherence to MD has been demonstrated to partially recover several sexual dysfunctions in women, such as those related to their menstrual cycle, menopause, endometriosis, and polycystic ovary syndrome. These favorable effects of MD have been demonstrated in both sexes also among people affected by MS. However, more targeted studies are needed to validate these data for different dietary approaches as well.
C1 [Oteri, Vittorio; Galeano, Francesco; Panebianco, Stefania; Piticchio, Tommaso; Le Moli, Rosario; Frittitta, Lucia; Vella, Veronica; Frasca, Francesco] Univ Catania, Garibaldi Nesima Hosp, Dept Clin & Expt Med, Endocrinol Sect, I-95122 Catania, CT, Italy.
   [Piticchio, Tommaso; Le Moli, Rosario] Univ Kore Enna, Dept Med & Surg, I-94100 Enna, EN, Italy.
   [Frittitta, Lucia] Univ Catania, Garibaldi Nesima Hosp, Diabet & Obes Ctr, I-95122 Catania, CT, Italy.
   [Baratta, Roberto; Gullo, Damiano; Frasca, Francesco; Tumminia, Andrea] Garibaldi Nesima Hosp, Endocrine Unit, I-95122 Catania, CT, Italy.
C3 University of Catania; Presidio Ospedaliero Garibaldi-Nesima; Universita
   Kore di ENNA; Presidio Ospedaliero Garibaldi-Nesima; University of
   Catania; Presidio Ospedaliero Garibaldi-Nesima
RP Frasca, F (corresponding author), Univ Catania, Garibaldi Nesima Hosp, Dept Clin & Expt Med, Endocrinol Sect, I-95122 Catania, CT, Italy.; Frasca, F (corresponding author), Garibaldi Nesima Hosp, Endocrine Unit, I-95122 Catania, CT, Italy.
EM research@droteri.it; francesco.galeano3@gmail.com;
   dottoressa.panebianco@gmail.com; tommaso.piticchio@unikore.it;
   rosario.lemoli@unikore.it; lucia.frittitta@unict.it;
   veronica.vella@unict.it; rob.baratta@gmail.com; gullo.family@alice.it;
   frascafranco@gmail.com; andreatumminia82@gmail.com
RI Vella, Dott.ssa/AAX-5690-2020; Piticchio, Tommaso/AHE-5143-2022;
   frittitta, lucia/J-2334-2012; Tumminia, Andrea/ABM-1770-2022; LEMOLI,
   ROBERTO/AAC-2370-2022; Baratta, Roberto/IQR-8839-2023
OI Baratta, Roberto/0000-0003-0524-4525; Panebianco,
   Stefania/0009-0003-8158-7332; Galeano, Francesco/0009-0004-4104-1105;
   Oteri, Vittorio/0000-0001-5210-8601; FRITTITTA,
   Lucia/0000-0002-7941-5828; LE MOLI, Rosario/0000-0002-1398-9271
FU University of Catania; National Recovery and Resilience Plan - European
   Union [PE00000003, 1550]
FX The article processing charge (APC) was funded by the University of
   Catania. The study was supported by the project entitled "ON
   Foods-Research and innovation network on food and nutrition
   Sustainability, Safety and Security-Working ON Foods" funded under the
   National Recovery and Resilience Plan (NRRP), Mission 4 Component 2
   Investment 1.3-Call for tender No. 341 of 15 March 2022 of Italian
   Ministry of University and Research funded by the European
   Union-NextGenerationEU; Project code PE00000003, Concession Decree No.
   1550 of 11 October 2022 adopted by the Italian Ministry of University
   and Research.
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NR 195
TC 3
Z9 3
U1 1
U2 5
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD OCT
PY 2024
VL 16
IS 19
AR 3397
DI 10.3390/nu16193397
PG 27
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA I7P5V
UT WOS:001332143000001
PM 39408364
OA gold
DA 2025-06-11
ER

PT J
AU Nishikawa, H
   Asai, A
   Fukunishi, S
   Nishiguchi, S
   Higuchi, K
AF Nishikawa, Hiroki
   Asai, Akira
   Fukunishi, Shinya
   Nishiguchi, Shuhei
   Higuchi, Kazuhide
TI Metabolic Syndrome and Sarcopenia
SO NUTRIENTS
LA English
DT Review
DE metabolic syndrome; sarcopenia; mechanism; insulin resistance;
   sarcopenic obesity; outcome
ID FATTY LIVER-DISEASE; MUSCLE MASS; VITAMIN-D; ELDERLY-MEN; POSTMENOPAUSAL
   WOMEN; INSULIN-RESISTANCE; ADIPOSE-TISSUE; OLDER-ADULTS;
   25-HYDROXYVITAMIN D; PHYSICAL FUNCTION
AB Skeletal muscle is a major organ of insulin-induced glucose metabolism. In addition, loss of muscle mass is closely linked to insulin resistance (IR) and metabolic syndrome (Met-S). Skeletal muscle loss and accumulation of intramuscular fat are associated with a variety of pathologies through a combination of factors, including oxidative stress, inflammatory cytokines, mitochondrial dysfunction, IR, and inactivity. Sarcopenia, defined by a loss of muscle mass and a decline in muscle quality and muscle function, is common in the elderly and is also often seen in patients with acute or chronic muscle-wasting diseases. The relationship between Met-S and sarcopenia has been attracting a great deal of attention these days. Persistent inflammation, fat deposition, and IR are thought to play a complex role in the association between Met-S and sarcopenia. Met-S and sarcopenia adversely affect QOL and contribute to increased frailty, weakness, dependence, and morbidity and mortality. Patients with Met-S and sarcopenia at the same time have a higher risk of several adverse health events than those with either Met-S or sarcopenia. Met-S can also be associated with sarcopenic obesity. In this review, the relationship between Met-S and sarcopenia will be outlined from the viewpoints of molecular mechanism and clinical impact.</p>
C1 [Nishikawa, Hiroki; Asai, Akira; Fukunishi, Shinya; Higuchi, Kazuhide] Osaka Med & Pharmaceut Univ, Dept Internal Med 2, Takatsuki, Osaka 5698686, Japan.
   [Nishikawa, Hiroki; Fukunishi, Shinya] Osaka Med & Pharmaceut Univ, Premier Dept Res Med, Takatsuki, Osaka 5698686, Japan.
   [Nishiguchi, Shuhei] Kano Gen Hosp, Osaka 5310041, Japan.
C3 Osaka Medical & Pharmaceutical University; Osaka Medical &
   Pharmaceutical University
RP Nishikawa, H (corresponding author), Osaka Med & Pharmaceut Univ, Dept Internal Med 2, Takatsuki, Osaka 5698686, Japan.; Nishikawa, H (corresponding author), Osaka Med & Pharmaceut Univ, Premier Dept Res Med, Takatsuki, Osaka 5698686, Japan.
EM nishikawa_6392@yahoo.co.jp; in2108@osaka-med.ac.jp;
   in2104@osaka-med.ac.jp; nishiguchi@heartfull.or.jp;
   kazuhide.higuchi@ompu.ac.jp
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NR 103
TC 176
Z9 183
U1 16
U2 81
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD OCT
PY 2021
VL 13
IS 10
AR 3519
DI 10.3390/nu13103519
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA WT9CV
UT WOS:000716155900001
PM 34684520
OA Green Published, gold
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Al Shammaa, A
   Al-Thani, A
   Al-Kaabi, M
   Al-Saeed, K
   Alanazi, M
   Shi, ZM
AF Al Shammaa, AlMaha
   Al-Thani, Amna
   Al-Kaabi, Maryam
   Al-Saeed, Kaltham
   Alanazi, Maria
   Shi, Zumin
TI Serum Magnesium is Inversely Associated with Body Composition and
   Metabolic Syndrome
SO DIABETES METABOLIC SYNDROME AND OBESITY
LA English
DT Article
DE serum magnesium; DEXA; body adiposity; total fat mass; Qatar Biobank;
   cross-sectional study
ID INSULIN-RESISTANCE; OBESITY; METAANALYSIS; RISK; DEPRESSION; CHILDREN;
   PLASMA; QATAR
AB Purpose: Magnesium is vital to maintain normal physiological functions. We aimed to identify the association between serum magnesium and different measures of body adiposity among Qatari adults. We hypothesized that the association was mediated by depression and sleep duration. Patients and Methods: The study included 1000 adults aged 20 years and above who attended the Qatar Biobank Study (QBB) between 2012 and 2019. Body adiposity was assessed using dual-energy X-ray absorptiometry (DEXA). Serum magnesium concen-tration was measured. Sub-optimal magnesium was defined as magnesium concentration less than 0.85 mmol/L. The association was examined using linear regression. Results: The mean age of the participants (n=1000) was 35.8 (SD 10.3) years. More than half of the participants had sub-optimal magnesium concentrations (60.2% in men and 52.3% in women). Serum magnesium was inversely associated with different types of fat mass. In the fully adjusted model, per 1 SD increment of serum magnesium had standardized regression coefficients of -0.09 (p 0.005) for total fat mass, -0.08 (p 0.008) for trunk fat, -0.09 (p 0.003) for gynoid fat and -0.08 (p 0.008) for android fat. There was no gender difference in the association. The inverse association between serum magnesium and fat mass was significant in those with sleep duration >= 7 hours but not in those <7 hours. Depressive symptom and sleep did not mediate the association between serum magnesium and fat mass. Serum magnesium was inversely associated with metabolic syndrome (per 1 SD increment had an odds ratio (OR) of 0.70 (95% CI 0.57-0.85)). Conclusion: There was an inverse association between serum magnesium and fat mass, especially among those with an adequate sleep duration and without chronic conditions including diabetes, hypertension and depression.
C1 [Al Shammaa, AlMaha; Al-Thani, Amna; Al-Kaabi, Maryam; Al-Saeed, Kaltham; Alanazi, Maria; Shi, Zumin] Qatar Univ, Coll Hlth Sci, Human Nutr Dept, QU Hlth, Doha, Qatar.
   [Shi, Zumin] Qatar Univ, Coll Hlth Sci, Human Nutr Dept, QU Hlth, POB 2713, Doha, Qatar.
C3 Qatar University; Qatar University
RP Shi, ZM (corresponding author), Qatar Univ, Coll Hlth Sci, Human Nutr Dept, QU Hlth, POB 2713, Doha, Qatar.
EM zumin@qu.edu.qa
RI Alanazi, Maria/HZI-6306-2023; Shi, Zumin/A-1093-2009
OI Shi, Zumin/0000-0002-3099-3299
FU Qatar University [QUST-1-CHS-2022-348]; Qatar National Library
FX Acknowledgments The authors would like to thank Qatar Biobank for
   providing the data. This research was supported by a grant from Qatar
   University (Grant No: QUST-1-CHS-2022-348) . The funders had no role in
   the study design, data collection and analysis, decision to publish, or
   preparation of the manuscript. The publication of this article was
   funded by the Qatar National Library.
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NR 46
TC 9
Z9 9
U1 1
U2 5
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-7007
J9 DIABET METAB SYND OB
JI Diabetes Metab. Syndr. Obes.
PY 2023
VL 16
BP 95
EP 104
DI 10.2147/DMSO.S391369
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 7Z0LP
UT WOS:000915259000001
PM 36760601
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Agrawal, A
   Mabalirajan, U
   Ahmad, T
   Ghosh, B
AF Agrawal, Anurag
   Mabalirajan, Ulaganathan
   Ahmad, Tanveer
   Ghosh, Balaram
TI Emerging Interface between Metabolic Syndrome and Asthma
SO AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
LA English
DT Review
DE ADMA; hyperinsulinism; obesity; arginine; mitochondrial dysfunction
ID BODY-MASS INDEX; GROWTH-FACTOR-I; ASYMMETRIC DIMETHYLARGININE;
   INSULIN-RESISTANCE; DIABETES-MELLITUS; CLUSTER-ANALYSIS; INCIDENT
   ASTHMA; LUNG-FUNCTION; NITRIC-OXIDE; MOUSE MODEL
AB There is growing epidemiological evidence that obesity increases the risk of developing asthma. In some studies, insulin resistance or metabolic syndrome is a stronger risk factor than body mass. The obese-asthma subphenotype is marked by a paucity of inflammation but also by marked symptoms, poor response to glucocorticoids, and peripheral airway dysfunction. Although obesity may predispose to increased Th2 inflammation or atopic tendencies, other mechanisms that are independent of inflammatory cells need to be considered. There is growing evidence of the influence of hyperglycemia, hyperinsulinemia, and insulin-like growth factors on airway structure and function. Also, studies from mouse models of asthma have highlighted the importance of nitric oxide-arginine metabolism abnormalities and oxonitrosative stress in lungs. Such changes are well established features of the metabolic syndrome and may represent an interface between these diseases that can be therapeutically targeted. Such therapies, including administration of L-arginine or statins, increasing endothelial nitric oxide synthase, or the use of arginase inhibitors, have been successful in experimental models but have not yet translated to the clinical arena. We review the current understanding of the potential mechanistic links between obesity and asthma, emphasizing the potential influence of metabolic abnormalities on asthmatic processes, therapeutic implications, and expected challenges.
C1 [Agrawal, Anurag; Mabalirajan, Ulaganathan; Ahmad, Tanveer; Ghosh, Balaram] Inst Genom & Integrat Biol, Ctr Translat Res Asthma & Lung Dis, Delhi, India.
C3 Council of Scientific & Industrial Research (CSIR) - India; CSIR -
   Institute of Genomics & Integrative Biology (IGIB)
RP Agrawal, A (corresponding author), Inst Genom & Integrat Biol, Ctr Translat Res Asthma & Lung Dis, Mall Rd, Delhi, India.
EM a.agrawal@igib.in
RI Agrawal, Anurag/A-7312-2009; Ahmad, Tanveer/ABX-8334-2022; Ghosh,
   Balaram/G-1248-2010
OI Ahmad, Tanveer/0000-0002-8384-5273; Mabalirajan,
   Ulaganathan/0000-0002-2547-1023; Agrawal, Anurag/0000-0002-0340-5252
FU Council of Scientific and Industrial Research, India [MLP5501, NWP33];
   BIOMARCK Pharmaceuticals
FX This work was supported by grants MLP5501 and NWP33 of Council of
   Scientific and Industrial Research, India. A.A. received a sponsored
   grant from BIOMARCK Pharmaceuticals for $10,001 to $50,000. T.A. does
   not have a financial relationship with a commercial entity that has an
   interest in the subject of this manuscript. B.G. does not have a
   financial relationship with a commercial entity that has an interest in
   the subject of this manuscript. U.M. does not have a financial
   relationship with a commercial entity that has an interest in the
   subject of this manuscript.
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NR 62
TC 88
Z9 91
U1 2
U2 16
PU AMER THORACIC SOC
PI NEW YORK
PA 25 BROADWAY, 18 FL, NEW YORK, NY 10004 USA
SN 1044-1549
EI 1535-4989
J9 AM J RESP CELL MOL
JI Am. J. Respir. Cell Mol. Biol.
PD MAR
PY 2011
VL 44
IS 3
BP 270
EP 275
DI 10.1165/rcmb.2010-0141TR
PG 6
WC Biochemistry & Molecular Biology; Cell Biology; Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology; Respiratory System
GA 753KN
UT WOS:000289772400004
PM 20656947
DA 2025-06-11
ER

PT J
AU dos Santos, LRB
   Fleming, I
AF dos Santos, Laila R. B.
   Fleming, Ingrid
TI Role of cytochrome P450-derived, polyunsaturated fatty acid mediators in
   diabetes and the metabolic syndrome
SO PROSTAGLANDINS & OTHER LIPID MEDIATORS
LA English
DT Review
DE Cytochrome P450 enzymes; Insulin resistance; Metabolic syndrome;
   Polyunsaturated fatty acids
ID SOLUBLE EPOXIDE HYDROLASE; ENDOPLASMIC-RETICULUM STRESS; ACTIVATED
   RECEPTOR-GAMMA; STIMULATED INSULIN-SECRETION; CA2+-ACTIVATED K+
   CHANNELS; EPOXYEICOSATRIENOIC ACIDS; FISH-OIL; EICOSAPENTAENOIC ACID;
   DOCOSAHEXAENOIC ACID; GUT MICROBIOTA
AB Over the last decade, cases of metabolic syndrome and type II diabetes have increased exponentially. Exercise and omega-3 polyunsaturated fatty acid (PUFA)-enriched diets are usually prescribed but no therapy is effectively able to restore the impaired glucose metabolism, hypertension, and atherogenic dyslipidemia encountered by diabetic patients. PUFAs are metabolized by different enzymes into bioactive metabolites with anti- or proinflammatory activity. One important class of PUFA metabolizing enzymes are the cytochrome P450 (CYP) enzymes that can generate a series of bioactive products, many of which have been attributed protective/antiinflammatory and insulin-sensitizing effects in animal models. PUFA epoxides are, however, further metabolized by the soluble epoxide hydrolase (sEH) to fatty acid diols. The biological actions of the latter are less well understood but while low concentrations may be biologically important, higher concentrations of diols derived from linoleic acid and docosahexaenoic acid have been linked with inflammation. One potential application for sEH inhibitors is in the treatment of diabetic retinopathy where sEH expression and activity is elevated as are levels of a diol of docosahexaenoic acid that can induce the destabilization of the retina vasculature.
C1 [dos Santos, Laila R. B.; Fleming, Ingrid] Goethe Univ, Ctr Mol Med, Inst Vasc Signalling, Theodor Stern Kai 7, D-60596 Frankfurt, Germany.
   [dos Santos, Laila R. B.; Fleming, Ingrid] German Ctr Cardiovasc Res DZHK, Partner Site Rhein Main, Frankfurt, Germany.
C3 Goethe University Frankfurt; German Centre for Cardiovascular Research
RP Fleming, I (corresponding author), Goethe Univ, Ctr Mol Med, Inst Vasc Signalling, Theodor Stern Kai 7, D-60596 Frankfurt, Germany.
EM fleming@em.uni-frankfurt.de
RI Fleming, Ingrid/L-1225-2014
OI Fleming, Ingrid/0000-0003-1881-3635
FU Deutsche Forschungsgemeinschaft [SFB 1039/2 A6]; Cardio-Pulmonary
   Institute [EXC 2026, 390649896]
FX This work was supported by the Deutsche Forschungsgemeinschaft (SFB
   1039/2 A6 to I.F. and the Cardio-Pulmonary Institute, EXC 2026, Project
   ID: 390649896).
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NR 207
TC 22
Z9 23
U1 2
U2 20
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1098-8823
EI 2212-196X
J9 PROSTAG OTH LIPID M
JI Prostaglandins Other Lipid Mediat.
PD JUN
PY 2020
VL 148
AR 106407
DI 10.1016/j.prostaglandins.2019.106407
PG 14
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA LP6LK
UT WOS:000534430200008
PM 31899373
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Calcaterra, V
   Biganzoli, G
   Ferraro, S
   Mari, A
   Mandelli, A
   Fabiano, V
   Carlucci, P
   Pelizzo, G
   Zoia, E
   Lanfranchi, G
   Castaldi, S
   Boracchi, P
   Biganzoli, E
   Zuccotti, G
AF Calcaterra, Valeria
   Biganzoli, Giacomo
   Ferraro, Simona
   Mari, Alessandra
   Mandelli, Anna
   Fabiano, Valentina
   Carlucci, Patrizia
   Pelizzo, Gloria
   Zoia, Elena
   Lanfranchi, Giulia
   Castaldi, Silvana
   Boracchi, Patrizia
   Biganzoli, Elia
   Zuccotti, Gianvincenzo
TI Thyroid Function and Metabolic Syndrome in Children and Adolescents with
   Neuromotor Disability
SO CHILDREN-BASEL
LA English
DT Article
DE thyroid function; thyroid hormones; disability; neuromotor impairment;
   metabolic syndrome; children
ID HORMONES; STRESS; NERVE; DISORDERS; PROLACTIN; MODEL
AB Thyroid function plays a crucial role in nervous system integrity and metabolic homeostasis. We evaluated the pattern of TSH, FT4 and FT3 release in children with neuromotor impairment (NI) in relationship with metabolic syndrome (MS). We enrolled 55 patients with NI and 30 controls. Clinical parameters, thyroid function and MS presence were recorded. Principal component analysis (PCA), cluster analysis, and logistic regression models were performed. MS was detected in 54.5% of patients. Four clusters were identified: the first one included only controls and, contrasting with cluster 4, was exclusively characterized by children with disability and MS. This latter showed increased FT4 and FT3 and decreased TSH levels. Cluster 2, characterized by disability without MS showed high FT4 and FT3, whereas cluster 3 with low FT4 and FT3 mainly included disability (90%) and showed prevalent MS (57%). The association between TSH and NI is represented by a U-shape structure. The TSH, FT3 and FT4 release patterns may reflect thyrotropic adaptation, allostatic response and compensatory mechanisms. These mechanisms, found in both MS and disability, show that the odds of having a condition of NI with or without MS increase as the TSH values deviate, in both directions, from a value of 2.5 mLU/mL.
C1 [Calcaterra, Valeria] Univ Pavia, Dept Internal Med, I-27100 Pavia, Italy.
   [Calcaterra, Valeria; Mari, Alessandra; Fabiano, Valentina; Carlucci, Patrizia; Zuccotti, Gianvincenzo] V Buzzi Childrens Hosp, Pediat Dept, I-20154 Milan, Italy.
   [Biganzoli, Giacomo; Boracchi, Patrizia; Biganzoli, Elia] Univ Milan, Univ Hosp, Dept Biomed & Clin Sci, Med Stat Unit, I-20157 Milan, Italy.
   [Ferraro, Simona] Luigi Sacco Univ Hosp, Endocrinol Lab Unit, I-20157 Milan, Italy.
   [Mandelli, Anna; Zoia, Elena] V Buzzi Childrens Hosp, Intens Care Unit, I-20154 Milan, Italy.
   [Fabiano, Valentina; Pelizzo, Gloria; Zuccotti, Gianvincenzo] Univ Milan, Dept Biomed & Clin Sci, I-20157 Milan, Italy.
   [Pelizzo, Gloria; Lanfranchi, Giulia] V Buzzi Childrens Hosp, Pediat Surg Dept, I-20154 Milan, Italy.
   [Castaldi, Silvana] Univ Milan, Dept Biomed Sci Hlth, I-20157 Milan, Italy.
   [Castaldi, Silvana] Fdn IRCCS Ca Granda Osped Maggiore Policlin, I-20122 Milan, Italy.
C3 University of Pavia; University of Milan; University of Milan; Luigi
   Sacco Hospital; University of Milan; University of Milan; IRCCS Ca
   Granda Ospedale Maggiore Policlinico
RP Calcaterra, V (corresponding author), Univ Pavia, Dept Internal Med, I-27100 Pavia, Italy.; Calcaterra, V (corresponding author), V Buzzi Childrens Hosp, Pediat Dept, I-20154 Milan, Italy.
EM valeria.calcaterra@unipv.it
RI Biganzoli, Elia/J-1678-2012; Calcaterra, Valeria/AAB-7563-2022; Ferraro,
   Simona/AAC-3514-2022; Patrizia, Boracchi/AAB-8851-2019; Lanfranchi,
   Giulia/MIO-8682-2025; FABIANO, VALENTINA/H-8818-2017; Zuccotti,
   Gianvincenzo/H-8572-2017; Castaldi, Silvana/L-1493-2016
OI FABIANO, VALENTINA/0000-0001-6449-1724; Lanfranchi,
   Giulia/0009-0000-2749-0896; Biganzoli, Elia/0000-0003-1202-5873;
   Zuccotti, Gianvincenzo/0000-0002-2795-9874; CALCATERRA,
   VALERIA/0000-0002-2137-5974; Mari, Alessandra/0000-0001-7418-1447;
   Castaldi, Silvana/0000-0003-1716-6624
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NR 32
TC 6
Z9 6
U1 0
U2 0
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2227-9067
J9 CHILDREN-BASEL
JI Children-Basel
PD OCT
PY 2022
VL 9
IS 10
AR 1531
DI 10.3390/children9101531
PG 20
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA 5O5FM
UT WOS:000872499100001
PM 36291467
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Nurcahyanti, ADR
   Cokro, F
   Wulanjati, MP
   Mahmoud, MF
   Wink, M
   Sobeh, M
AF Nurcahyanti, Agustina Dwi Retno
   Cokro, Fonny
   Wulanjati, Martha P.
   Mahmoud, Mona F.
   Wink, Michael
   Sobeh, Mansour
TI Curcuminoids for Metabolic Syndrome: Meta-Analysis Evidences Toward
   Personalized Prevention and Treatment Management
SO FRONTIERS IN NUTRITION
LA English
DT Review
DE metabolic syndrome; curcumin; curcuminoid; turmeric; personalized
   treatment; gut microbiome; meta-analysis; randomized controlled trial
ID FATTY LIVER-DISEASE; TYPE-2 DIABETES-MELLITUS; C-REACTIVE PROTEIN;
   NF-KAPPA-B; OXIDATIVE STRESS; GUT MICROBIOTA; INSULIN-RESISTANCE;
   CURCUMA-LONGA; ANTIOXIDANT BALANCE; PHYTOSOMAL CURCUMIN
AB The metabolic syndrome (MS) is a multifactorial syndrome associated with a significant economic burden and healthcare costs. MS management often requires multiple treatments (polydrug) to ameliorate conditions such as diabetes mellitus, insulin resistance, obesity, cardiovascular diseases, hypertension, and non-alcoholic fatty liver disease (NAFLD). However, various therapeutics and possible drug-drug interactions may also increase the risk of MS by altering lipid and glucose metabolism and promoting weight gain. In addition, the medications cause side effects such as nausea, flatulence, bloating, insomnia, restlessness, asthenia, palpitations, cardiac arrhythmias, dizziness, and blurred vision. Therefore, is important to identify and develop new safe and effective agents based on a multi-target approach to treat and manage MS. Natural products, such as curcumin, have multi-modalities to simultaneously target several factors involved in the development of MS. This review discusses the recent preclinical and clinical findings, and up-to-date meta-analysis from Randomized Controlled Trials regarding the effects of curcumin on MS, as well as the metabonomics and a pharma-metabolomics outlook considering curcumin metabolites, the gut microbiome, and environment for a complementary personalized prevention and treatment for MS management.
C1 [Nurcahyanti, Agustina Dwi Retno; Cokro, Fonny] Atma Jaya Catholic Univ Indonesia, Sch Med & Hlth Sci, Dept Pharm, Jakarta, Indonesia.
   [Wulanjati, Martha P.] Natl Res & Innovat Agcy BRIN, Res Div Nat Prod Technol BPTBA, Yogyakarta, Indonesia.
   [Mahmoud, Mona F.] Zagazig Univ, Fac Pharm, Dept Pharmacol & Toxicol, Zagazig, Egypt.
   [Wink, Michael] Heidelberg Univ, Inst Pharm & Mol Biotechnol IPMB, Heidelberg, Germany.
   [Sobeh, Mansour] Mohammed VI Polytech Univ, AgroBioSci Dept, Ben Guerir, Morocco.
C3 University Katolik Indonesia Atma Jaya; National Research & Innovation
   Agency of Indonesia (BRIN); Egyptian Knowledge Bank (EKB); Zagazig
   University; Ruprecht Karls University Heidelberg; Mohammed VI
   Polytechnic University
RP Nurcahyanti, ADR (corresponding author), Atma Jaya Catholic Univ Indonesia, Sch Med & Hlth Sci, Dept Pharm, Jakarta, Indonesia.; Sobeh, M (corresponding author), Mohammed VI Polytech Univ, AgroBioSci Dept, Ben Guerir, Morocco.
EM adr.nurcahyanti@atmajaya.ac.id; mansour.sobeh@um6p.ma
RI Mahmoud, Mona/Q-8851-2019; Sobeh, Mansour/AAY-6521-2021; Nurcahyanti,
   Agustina/ABY-9586-2022; Wink, Michael/E-3803-2012
OI Cokro, Fonny/0000-0002-9810-1402; Sobeh, Mansour/0000-0002-2719-8534;
   Wink, Michael/0000-0002-7875-4510
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NR 196
TC 17
Z9 17
U1 7
U2 23
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD JUN 9
PY 2022
VL 9
AR 891339
DI 10.3389/fnut.2022.891339
PG 19
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 2I5BL
UT WOS:000814993400001
PM 35757255
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Tesauro, M
   Cardillo, C
AF Tesauro, M.
   Cardillo, C.
TI Obesity, blood vessels and metabolic syndrome
SO ACTA PHYSIOLOGICA
LA English
DT Review
DE Endothelium; insulin; metabolic syndrome; obesity; oxidative stress;
   vascular reactivity
ID ENDOTHELIUM-DEPENDENT VASODILATION; EPICARDIAL ADIPOSE-TISSUE; SYNTHASE
   MESSENGER-RNA; NITRIC-OXIDE SYNTHASE; INSULIN-RESISTANCE; MICROVASCULAR
   RECRUITMENT; PERIVASCULAR FAT; GLUCOSE-UPTAKE; VASCULAR-TONE; TNF-ALPHA
AB Obesity is rising worldwide at an alarming rate and so is the incidence of obesity-related disorders, such as the metabolic syndrome, type 2 diabetes and cardiovascular diseases. The obesity-dependent vascular damage appears to be derived from a variety of changes in the adipose tissue, leading to a chronic inflammatory state and dysregulation of adipocyte-derived factors. This, in turn, impairs vascular homeostasis by determining an unbalance between the protective effect of the nitric oxide pathway and the unfavourable action of the endothelin-1 system. In addition, hyperinsulinemia and insulin resistance contribute to vascular dysfunction because the opposing endothelium-dependent vasodilating and vasoconstrictor effects of insulin are shifted towards a predominant vasoconstriction in patients with obesity. Importantly, emerging evidence suggests that the vascular dysfunction of obesity is not only limited to the endothelium but also involves the other layers of the vessel wall. In particular, obesity-related changes in vascular smooth muscle seem to disrupt the physiological facilitatory action of insulin on the responsiveness to vasodilator stimuli, whereas the adventitia and the perivascular fat appear to be a source of proinflammatory and vasoactive factors that may contribute to endothelial and smooth muscle cell dysfunction and to the pathogenesis of vascular disease.
C1 [Cardillo, C.] Univ Cattolica Sacro Cuore, Ist Patol Speciale Med & Semeiot, Dept Internal Med, I-00168 Rome, Italy.
   [Tesauro, M.] Univ Roma Tor Vergata, Dept Internal Med, Rome, Italy.
C3 Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli;
   University of Rome Tor Vergata
RP Cardillo, C (corresponding author), Univ Cattolica Sacro Cuore, Ist Patol Speciale Med & Semeiot, Dept Internal Med, Largo Gemelli 8, I-00168 Rome, Italy.
EM carmine.cardillo@rm.unicatt.it
OI Cardillo, Carmine/0000-0001-5182-3005
FU Fondazione Roma; Universita Cattolica del Sacro Cuore
FX This work was supported by a grant from the Fondazione Roma to M.
   Tesauro and by Fondi d'Ateneo grants from the Universita Cattolica del
   Sacro Cuore to C. Cardillo.
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NR 62
TC 77
Z9 86
U1 1
U2 12
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1748-1708
EI 1748-1716
J9 ACTA PHYSIOL
JI Acta Physiol.
PD SEP
PY 2011
VL 203
IS 1
SI SI
BP 279
EP 286
DI 10.1111/j.1748-1716.2011.02290.x
PG 8
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA 807TA
UT WOS:000293921400026
PM 21439028
DA 2025-06-11
ER

PT J
AU Valado, A
   Cunha, M
   Pereira, L
AF Valado, Ana
   Cunha, Margarida
   Pereira, Leonel
TI Biomarkers and Seaweed-Based Nutritional Interventions in Metabolic
   Syndrome: A Comprehensive Review
SO MARINE DRUGS
LA English
DT Review
DE metabolic syndrome; obesity; cardiovascular disease; biomarkers;
   therapy; marine algae
ID BLOOD-PRESSURE; OBESITY; ALGAE
AB Metabolic Syndrome (MetS) is a complex, multifactorial condition characterized by risk factors such as abdominal obesity, insulin resistance, dyslipidemia and hypertension, which significantly contribute to the development of cardiovascular disease (CVD), the leading cause of death worldwide. Early identification and effective monitoring of MetS is crucial for preventing serious cardiovascular complications. This article provides a comprehensive overview of various biomarkers associated with MetS, including lipid profile markers (triglyceride/high-density lipoprotein cholesterol (TG/HDL-C) ratio and apolipoprotein B/apolipoprotein A1 (ApoB/ApoA1) ratio), inflammatory markers (interleukin 6 (IL-6), tumor necrosis factor alpha (TNF-alpha), plasminogen activator inhibitor type 1 (PAI-1), C-reactive protein (CRP), leptin/adiponectin ratio, omentin and fetuin-A/adiponectin ratio), oxidative stress markers (lipid peroxides, protein and nucleic acid oxidation, gamma-glutamyl transferase (GGT), uric acid) and microRNAs (miRNAs) such as miR-15a-5p, miR5-17-5p and miR-24-3p. Additionally, this review highlights the importance of biomarkers in MetS and the need for advancements in their identification and use for improving prevention and treatment. Seaweed therapy is also discussed as a significant intervention for MetS due to its rich content of fiber, antioxidants, minerals and bioactive compounds, which help improve cardiovascular health, reduce inflammation, increase insulin sensitivity and promote weight loss, making it a promising nutritional strategy for managing metabolic and cardiovascular health.
C1 [Valado, Ana; Cunha, Margarida] Polytech Univ Coimbra, Coimbra Hlth Sch, Biomed Lab Sci, Rua 5 Outubro S Martinho Bispo,Apartado 7006, P-3045043 Coimbra, Portugal.
   [Valado, Ana] Polytech Univ Coimbra, Res Ctr Nat Resources Environm Soc CERNAS, P-3045601 Bencanta, Coimbra, Portugal.
   [Valado, Ana] Univ Coimbra, MARE Marine & Environm Sci Ctr, ARNET Aquat Res Network, P-3000456 Coimbra, Portugal.
   [Valado, Ana] Polytech Univ Coimbra, H&TRC Hlth & Technol Res Ctr, Coimbra Hlth Sch, Rua 5 Outubro, P-3045043 Coimbra, Portugal.
   [Pereira, Leonel] Univ Coimbra, Ctr Funct Ecol Sci People & Planet, Dept Life Sci, Marine Resources Conservat & Technol Marine Algae, P-3000456 Coimbra, Portugal.
C3 Universidade de Coimbra; Universidade de Coimbra
RP Valado, A (corresponding author), Polytech Univ Coimbra, Coimbra Hlth Sch, Biomed Lab Sci, Rua 5 Outubro S Martinho Bispo,Apartado 7006, P-3045043 Coimbra, Portugal.; Valado, A (corresponding author), Polytech Univ Coimbra, Res Ctr Nat Resources Environm Soc CERNAS, P-3045601 Bencanta, Coimbra, Portugal.; Valado, A (corresponding author), Univ Coimbra, MARE Marine & Environm Sci Ctr, ARNET Aquat Res Network, P-3000456 Coimbra, Portugal.; Valado, A (corresponding author), Polytech Univ Coimbra, H&TRC Hlth & Technol Res Ctr, Coimbra Hlth Sch, Rua 5 Outubro, P-3045043 Coimbra, Portugal.
EM valado@estesc.ipc.pt; margaridacunha2002@hotmail.com;
   leonel.pereira@uc.pt
RI Valado, Ana/ABG-5698-2020; Valado, Ana/ADI-6397-2022; Pereira,
   Leonel/M-3527-2013
OI Valado, Ana/0000-0002-0157-6648; Pereira, Leonel/0000-0002-6819-0619
FU Portuguese Foundation for Science and Technology (FCT)
   [UIDB/00681/2020]; FCT-Fundacao para a Ciencia e Tecnologia, I.P.
   [UIDB/04004/2020]
FX The author AV thanks the Portuguese Foundation for Science and
   Technology (FCT) for the financial support to the Research Centre for
   Natural Resources, Environment and Society-CERNAS (UIDB/00681/2020;
   doi:10.54499/UIDP/00681/2020). This work was also supported by
   FCT-Fundacao para a Ciencia e Tecnologia, I.P., in the framework of the
   Project UIDB/04004/2020 and DOI identifier 10.54499/UIDB/04004/2020
   (doi:10.54499/UIDB/04004/2020 accessed on 30 July 2024).
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NR 104
TC 1
Z9 1
U1 0
U2 0
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1660-3397
J9 MAR DRUGS
JI Mar. Drugs
PD DEC
PY 2024
VL 22
IS 12
AR 550
DI 10.3390/md22120550
PG 28
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA Q4Y6D
UT WOS:001384757300001
PM 39728125
OA gold
DA 2025-06-11
ER

PT J
AU Alshehri, FF
AF Alshehri, Faez Falah
TI Understanding the prevalence, progression, and management of metabolic
   syndrome in Saudi Arabia
SO SAUDI MEDICAL JOURNAL
LA English
DT Review
DE metabolic syndrome (MetS); hypertension; insulin resistance; diabetes;
   obesity; phytochemicals
ID PHOENIX-DACTYLIFERA L.; C-REACTIVE PROTEIN; NECROSIS-FACTOR-ALPHA;
   HEART-RATE-VARIABILITY; INSULIN-RESISTANCE; CARDIOVASCULAR-DISEASE;
   DIETARY FIBER; EICOSAPENTAENOIC ACID; MYOCARDIAL-INFARCTION;
   PHENOLIC-COMPOUNDS
AB Metabolic syndrome (MetS) is characterized by the coexistence of several disorders comprising hypertension, abdominal obesity, insulin sensitivity, and dyslipidemia. In recent times, MetS has gained increased attention due to the global prevalence of obesity. Adipose tissue plays a crucial role in this syndrome by releasing various molecules significantly affecting lipid/insulin regulation, oxidative stress, and cardiovascular function. Tumor necrosis factor-alpha (p-alpha), an inflammatory cytokine, and adiponectin, an adipose tissue-specific protein, are considered vital adipokines that play a significant role in the pathogenesis of MetS. The impact of dietary ingredients on MetS management has been extensively studied over the past few decades. These plant-derived natural chemicals have demonstrated beneficial impacts on obesity, diabetes, and cardiovascular disease (CVD) due to their diverse properties. Saudi Arabia has a high prevalence of overweight and diabetes, but there has been limited research on the incidence of MetS in the country. As a result, in this review, we evaluated the prevalence of MetS in Saudi Arabia and its associated risk factors, as well as explored the mechanisms of progression of MetS and the role of natural phytochemicals in the prevention of MetS.
C1 [Alshehri, Faez Falah] Shaqra Univ, Coll Appl Med Sci, Dept Clin Lab Sci, Shaqra, Saudi Arabia.
C3 Shaqra University
RP Alshehri, FF (corresponding author), Shaqra Univ, Coll Appl Med Sci, Dept Clin Lab Sci, Shaqra, Saudi Arabia.
EM falshehri@su.edu.sa
RI ALSHEHRI, FAEZ/GZG-4968-2022
OI Alshehri, Faez/0000-0001-7991-0987
FU Deanship of Scientific Research at Shaqra University
FX Acknowledgment. The author would like to thank the Deanship of
   Scientific Research at Shaqra University for supporting this work. The
   author would also like to acknowledge ContentCincepts (
   www.contentconcepts.com ) for the English language editing.
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NR 140
TC 4
Z9 4
U1 0
U2 3
PU SAUDI MED J
PI RIYADH
PA ARMED FORCES HOSPITAL, PO BOX 7897,, RIYADH 11159, SAUDI ARABIA
SN 0379-5284
EI 1658-3175
J9 SAUDI MED J
JI Saudi Med. J.
PD OCT 1
PY 2023
VL 44
IS 10
BP 973
EP 986
DI 10.15537/smj.2023.44.10.20230450
PG 14
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA X3UV1
UT WOS:001097747200003
PM 37777274
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Dehelean, L
   Romosan, AM
   Manea, MM
   Papava, I
   Andor, M
   Romosan, RS
AF Dehelean, L.
   Romosan, A. M.
   Manea, M. M.
   Papava, I
   Andor, M.
   Romosan, R. S.
TI THE METABOLIC SYNDROME IN OUTPATIENTS WITH PSYCHOSIS: A COMPARATIVE
   STUDY BETWEEN LONG ACTING INJECTABLE OLANZAPINE AND RISPERIDONE
SO ACTA ENDOCRINOLOGICA-BUCHAREST
LA English
DT Article
DE metabolic syndrome; long acting injectable; olanzapine; risperidone
ID INDUCED WEIGHT-GAIN; ATYPICAL ANTIPSYCHOTICS; DIABETES-MELLITUS;
   SCHIZOPHRENIA; PREVALENCE; SMOKING; PEOPLE; RISK
AB Context. Literature shows that patients taking antipsychotic medication risk developing metabolic complications.
   Objective. The study aims to compare the presence of the metabolic syndrome (MS) and its components in outpatients treated with long acting injectable (LAI) olanzapine and risperidone.
   Design. A double-center study was performed on outpatients with psychosis, which were divided into two samples: one treated with olanzapine and another with risperidone.
   Subjects and Methods. The following data were analyzed: age, gender, severity of psychiatric symptoms, blood pressure, waist circumference, fasting blood glucose, lipid profile, tobacco use, medication, and time intervals related to psychosis duration (pre-LAI and LAI treatment).
   Results. The study included 77 patients with schizophrenia and schizoaffective disorder. MS was present in 45 (58.4%) patients. Subjects with MS and abdominal obesity had higher durations of psychosis and of LAI treatment. Patients with hypertension had a higher pre-LAI treatment interval. Risperidone was associated with higher rates of hypertension and higher values of abdominal circumference than olanzapine.
   Conclusions. The presence of MS is related to the duration of the psychosis and the time spent on LAI treatment with no differences between olanzapine and risperidone. Hypertension may be a consequence of age, disorder induced stress, or of treatment with risperidone.
C1 [Dehelean, L.; Romosan, A. M.; Papava, I; Romosan, R. S.] Victor Babes Univ Med & Pharm, Dept Neurosci, Timisoara, Romania.
   [Andor, M.] Victor Babes Univ Med & Pharm, Med Semiol 2, Timisoara, Romania.
   [Manea, M. M.] Cty Clin Emergency Hosp, Dept Psychiat, Cluj Napoca, Romania.
   [Manea, M. M.] Iuliu Hatieganu Univ Med & Pharm, Fac Med, Dept Med Educ, Cluj Napoca, Romania.
C3 Victor Babes University of Medicine & Pharmacy, Timisoara; Victor Babes
   University of Medicine & Pharmacy, Timisoara; Iuliu Hatieganu University
   of Medicine & Pharmacy
RP Romosan, AM (corresponding author), Victor Babes Univ Med & Pharm, 2 Eftimie Murgu Sq, Timisoara 300041, Romania.
EM ana.romosan@gmail.com
RI Romosan, Radu-Stefan/B-3402-2016; Romosan, Ana/LWH-7382-2024; Andor,
   Minodora/KEH-5890-2024; Papava, Ion/ADB-0622-2022; Dehelean,
   Liana/P-2768-2016
OI ROMOSAN, RADU-STEFAN/0000-0001-6823-5277
CR Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
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NR 36
TC 4
Z9 4
U1 0
U2 4
PU EDITURA ACAD ROMANE
PI BUCURESTI
PA CALEA 13 SEPTEMBRIE NR 13, SECTOR 5, BUCURESTI 050711, ROMANIA
SN 1841-0987
EI 1843-066X
J9 ACTA ENDOCRINOL-BUCH
JI Acta Endocrinol.
PD JUL-SEP
PY 2019
VL 15
IS 3
BP 342
EP 348
DI 10.4183/aeb.2019.342
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA KQ4FP
UT WOS:000516880800010
PM 32010353
OA Green Published
DA 2025-06-11
ER

PT J
AU Hickman, IJ
   Hannigan, AK
   Johnston, HE
   Elvin-Walsh, L
   Mayr, HL
   Staudacher, HM
   Barnett, A
   Stoney, R
   Salisbury, C
   Jarrett, M
   Reeves, MM
   Coombes, JS
   Campbell, KL
   Keating, SE
   Macdonald, GA
AF Hickman, Ingrid J.
   Hannigan, Amy K.
   Johnston, Heidi E.
   Elvin-Walsh, Louise
   Mayr, Hannah L.
   Staudacher, Heidi M.
   Barnett, Amandine
   Stoney, Rachel
   Salisbury, Chloe
   Jarrett, Maree
   Reeves, Marina M.
   Coombes, Jeff S.
   Campbell, Katrina L.
   Keating, Shelley E.
   Macdonald, Graeme A.
TI Telehealth-delivered, Cardioprotective Diet and Exercise Program for
   Liver Transplant Recipients: A Randomized Feasibility Study
SO TRANSPLANTATION DIRECT
LA English
DT Article
ID QUALITY-OF-LIFE; ACHIEVE HIGH ADHERENCE; LOW-FAT DIETS; MEDITERRANEAN
   DIET; CARDIOVASCULAR RISK; INTERVENTION; ADULTS; DISEASE; HEART;
   AUSTRALIANS
AB Background.
   Rapid excess weight gain and metabolic complications contribute to poor outcomes following liver transplant care. Providing specialist lifestyle intervention with equitable access is a challenge for posttransplant service delivery.
   Methods.
   This study investigated the feasibility of a 12-wk telehealth delivered lifestyle intervention for liver transplant recipients (randomized controlled trial with a delayed intervention control group). The intervention included 14 group sessions facilitated by nutrition and exercise specialists via video streaming telehealth and participants used their own devices. Feasibility was assessed across session attendance, the adequacy, acceptability, and confidence with the telehealth technology and adherence to diet (Mediterranean Diet Adherence Score). Secondary pooled analysis of effectiveness was determined from changes in quality of life and metabolic syndrome severity score.
   Results.
   Of the 35 participants randomized, dropout was 22.8% (n = 8) and overall session attendance rate was 60%. Confidence with and adequacy of home technology was rated high in 96% and 91% of sessions, respectively. Participants randomized to the intervention significantly improved Mediterranean Diet Adherence Score (2-point increase [95% confidence interval, 1.5-3.4] versus control 0 point change [95% confidence interval, -1.4 to 1.2]; P = 0.004). Intervention (within group) analysis found the intervention significantly decreased the metabolic syndrome severity score (-0.4 [95% confidence interval, -0.6 to -0.1] P = 0.01), and improved mental health-related quality of life (2.5 [95% confidence interval, 0.4-4.6] P = 0.03).
   Conclusions.
   A cardioprotective lifestyle intervention delivered via telehealth is feasible for liver transplant recipients and may improve access to specialist care to support metabolic health and wellness after transplant.
C1 [Hickman, Ingrid J.; Hannigan, Amy K.; Johnston, Heidi E.; Elvin-Walsh, Louise; Mayr, Hannah L.; Staudacher, Heidi M.; Barnett, Amandine; Stoney, Rachel; Campbell, Katrina L.] Princess Alexandra Hosp, Dept Nutr & Dietet, Brisbane, Qld, Australia.
   [Hickman, Ingrid J.] Univ Queensland, Mater Res Inst, Brisbane, Qld, Australia.
   [Hickman, Ingrid J.; Mayr, Hannah L.; Campbell, Katrina L.; Macdonald, Graeme A.] Univ Queensland, Fac Med, Brisbane, Qld, Australia.
   [Mayr, Hannah L.; Barnett, Amandine] Bond Univ, Fac Hlth Sci & Med, Nutr & Dietet Res Grp, Gold Coast, Qld, Australia.
   [Salisbury, Chloe; Coombes, Jeff S.; Keating, Shelley E.] Univ Queensland, Sch Human Movement & Nutr Sci, Brisbane, Qld, Australia.
   [Jarrett, Maree; Macdonald, Graeme A.] Princess Alexandra Hosp, Queensland Liver Transplant Serv, Brisbane, Qld, Australia.
   [Campbell, Katrina L.] Griffith Univ, Menzies Hlth Inst, Ctr Appl Hlth Econ, Brisbane, Qld, Australia.
   [Macdonald, Graeme A.] Princess Alexandra Hosp, Dept Gastroenterol & Hepatol, Brisbane, Qld, Australia.
C3 Princess Alexandra Hospital; University of Queensland; Mater Research;
   University of Queensland; Bond University; University of Queensland;
   Princess Alexandra Hospital; Griffith University; Menzies Health
   Institute Queensland; Princess Alexandra Hospital
RP Hickman, IJ (corresponding author), Princess Alexandra Hosp, Dept Nutr & Dietet, Ipswich Rd, Woolloongabba, Qld 4102, Australia.
EM i.hickman@uq.edu.au
RI Reeves, Marina/B-3813-2009; Staudacher, Heidi/AAC-8193-2022; Campbell,
   Katrina/A-2290-2013; Keating, Shelley/P-2520-2015; Staudacher, Heidi
   M/D-2700-2017; Macdonald, Graeme A/K-4167-2013; Hickman, Ingrid
   J/P-8364-2016
OI Keating, Shelley/0000-0001-5357-2721; Barnett,
   Amandine/0000-0003-1509-1729; Staudacher, Heidi M/0000-0001-6704-2131;
   Macdonald, Graeme A/0000-0003-0929-110X; Salisbury,
   Chloe/0000-0001-8974-9736; Hickman, Ingrid J/0000-0003-3205-9165; Mayr,
   Hannah L/0000-0001-7356-653X
FU Princess Alexandra Hospital Research Support Scheme, Princess Alexandra
   Hospital Research Foundation; Allied Health Professionals Office of
   Queensland
FX Project funding was received from the Princess Alexandra Hospital
   Research Support Scheme, Princess Alexandra Hospital Research
   Foundation, and the Allied Health Professionals Office of Queensland.
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NR 57
TC 28
Z9 30
U1 0
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 2373-8731
J9 TRANSPLANT DIRECT
JI Transplant. Direct.
PD MAR
PY 2021
VL 7
IS 3
AR e667
DI 10.1097/TXD.0000000000001118
PG 10
WC Transplantation
WE Emerging Sources Citation Index (ESCI)
SC Transplantation
GA RM3VL
UT WOS:000639591800004
PM 33564717
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Krawczuk-Rybak, M
   Panasiuk, A
   Czygier, M
   Muszynska-Roslan, K
   Wysocka, J
   Szmitkowski, M
AF Krawczuk-Rybak, Maryna
   Panasiuk, Anna
   Czygier, Malgorzata
   Muszynska-Roslan, Katarzyna
   Wysocka, Jolanta
   Szmitkowski, Maciej
TI Total antioxidant status (TAS) in childhood cancer survivors
SO FOLIA HISTOCHEMICA ET CYTOBIOLOGICA
LA English
DT Article
DE cancer survivors; children; antioxidants; metabolic syndrome
ID ACUTE LYMPHOBLASTIC-LEUKEMIA; OXIDATIVE STRESS; CHILDREN; OBESITY;
   CHEMOTHERAPY; IMPACT; DAMAGE
AB Total antioxidant status (TAS), and the influence of treatment and correlation between TAS and parameters involved in metabolic syndrome (MS) in pediatric cancer survivors were evaluated. One hundred children and adolescents were studied. Twenty-five survivors received radiotherapy, 12 were obese or overweight. Additionally, we analyzed TAS in eight children with acute lymphoblastic leukemia (ALL) at diagnosis and during treatment after remission induction. The control group consisted of 22 healthy children. Serum concentrations of TAS, glucose, cholesterol, HDL-cholesterol, triglycerides, fibrinogen and insulin were measured. In cancer survivors, independently of diagnosis and kind of treatment (radiotherapy anthracyclines administration), the mean serum TAS did not differ significantly from the control group. No correlations were observed with age at the time of diagnosis or interval after the end of treatment. TAS values did not correlate with traits of the metabolic syndrome. In a group of eight patients with ALL at diagnosis and after induction of remission, TAS values were lower than in the control and cancer survivor groups. Antioxidant status was not found to be deteriorated in children after anticancer treatment, irrespective of diagnosis or kind of treatment, which might indicate sufficient antioxidant prevention. However, the possibility of the development of MS and cardiovascular disease in adulthood indicates the need for future studies. (Folia Histochemica et Cytobiologica 2012, Vol. 50, No. 3, 468-472)
C1 [Krawczuk-Rybak, Maryna; Panasiuk, Anna; Muszynska-Roslan, Katarzyna] Med Univ Bialystok, Dept Pediat Oncol & Hematol, PL-15274 Bialystok, Poland.
   [Czygier, Malgorzata; Szmitkowski, Maciej] Med Univ Bialystok, Dept Biochem Diagnost, PL-15274 Bialystok, Poland.
   [Wysocka, Jolanta] Med Univ Bialystok, Dept Pediat Lab Diagnost, PL-15274 Bialystok, Poland.
C3 Medical University of Bialystok; Medical University of Bialystok;
   Medical University of Bialystok
RP Krawczuk-Rybak, M (corresponding author), Med Univ Bialystok, Dept Pediat Oncol & Hematol, Waszyngtona Str 17, PL-15274 Bialystok, Poland.
EM rybak@umwb.edu.pl
RI Muszyńska-Rosłan, Katarzyna/U-7749-2018; Krawczuk-Rybak,
   Maryna/T-6734-2018
OI Krawczuk-Rybak, Maryna/0000-0003-0899-5930
CR Al-Tonbary Y, 2011, HEMATOLOGY, V16, P14, DOI 10.1179/102453311X12902908411553
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NR 28
TC 5
Z9 5
U1 0
U2 5
PU VIA MEDICA
PI GDANSK
PA UL SWIETOKRZYSKA 73, 80-180 GDANSK, POLAND
SN 0239-8508
EI 1897-5631
J9 FOLIA HISTOCHEM CYTO
JI Folia Histochem. Cytobiol.
PY 2012
VL 50
IS 3
BP 468
EP 472
DI 10.5603/FHC.2012.0065
PG 5
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA 049QU
UT WOS:000311999300022
PM 23042281
OA gold
DA 2025-06-11
ER

PT J
AU Giral, P
   Jacob, N
   Dourmap, C
   Hansel, B
   Carrie, A
   Bruckert, E
   Girerd, X
   Chapman, MJ
AF Giral, Philippe
   Jacob, Nelly
   Dourmap, Caroline
   Hansel, Boris
   Carrie, Alain
   Bruckert, Eric
   Girerd, Xavier
   Chapman, M. John
TI Elevated gamma-glutamyltransferase activity and perturbed thiol profile
   are associated with features of metabolic syndrome
SO ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
LA English
DT Article
DE metabolic syndrome; gamma-glutamyltransferase; glutathione; cysteine;
   oxidation
ID LOW-DENSITY-LIPOPROTEIN; CARDIOVASCULAR-DISEASE MORTALITY; HUMAN
   ATHEROSCLEROTIC PLAQUES; OXIDATIVE STRESS; INSULIN-RESISTANCE;
   RISK-FACTOR; HYPERLIPIDEMIC PATIENTS; MYOCARDIAL-INFARCTION;
   VASCULAR-DISEASE; AUSTRIAN ADULTS
AB Background-Prospective cohort studies have revealed that plasma gamma-glutamyltransferase (GGT) activity exhibits a positive association with coronary artery disease. GGT which is equally elevated in metabolic syndrome (MS), is the major regulator of circulating concentrations of thiol compounds derived from glutathione (GSH) cleavage, ie, cysteine and cysteinyl glycine. We compared the circulating thiol profile in a cohort of patients displaying atherogenic dyslipidemia with and without MS.
   Methods and Results-This cross-sectional study involved 1131 dyslipidemic patients in primary prevention of whom 26% presented with MS. GGT activity and plasma cysteinyl-glycine and cysteine concentrations were higher in MS patients; by contrast, levels of GSH were significantly lower (P < 10 to 4 for all comparisons versus patients without MS). We compared patient groups on the basis of the number of MS criteria which were concomitantly present. A progressive decrease in glutathione levels in contrast to a progressive increase in both cysteinyl-glycine and cysteine levels, and GGT activity, was observed as a function of the number of MS components in the overall population (P for trend < 10(-6)).
   Conclusion-Dyslipidemic patients exhibiting MS are characterized by elevated GGT activity which is associated with perturbed metabolism of thiol compounds.
C1 [Giral, Philippe; Dourmap, Caroline; Hansel, Boris; Bruckert, Eric; Girerd, Xavier] Univ Paris 06, Grp Hop Pitie Salpetriere, Unites Prevent Cardiovasc, Serv Endocrinol Metab,AP HP, F-75651 Paris, France.
   [Jacob, Nelly] Univ Paris 06, Grp Hop Pitie Salpetriere, Biochim Lab, AP HP, F-75651 Paris, France.
   [Giral, Philippe; Hansel, Boris; Carrie, Alain; Bruckert, Eric; Girerd, Xavier; Chapman, M. John] Univ Paris 06, INSERM, UMRS 551, Dyslipoproteinemia & Atherosclerosis Res Unit, F-75651 Paris, France.
   [Carrie, Alain] Univ Paris 06, Serv Biochim Med, AP HP, Grp Hop Pitie Salpetriere, F-75651 Paris, France.
C3 Sorbonne Universite; Assistance Publique Hopitaux Paris (APHP); Hopital
   Universitaire Pitie-Salpetriere - APHP; Sorbonne Universite; Assistance
   Publique Hopitaux Paris (APHP); Hopital Universitaire Pitie-Salpetriere
   - APHP; Sorbonne Universite; Institut National de la Sante et de la
   Recherche Medicale (Inserm); Assistance Publique Hopitaux Paris (APHP);
   Hopital Universitaire Pitie-Salpetriere - APHP; Sorbonne Universite
RP Giral, P (corresponding author), Univ Paris 06, Grp Hop Pitie Salpetriere, Unites Prevent Cardiovasc, Serv Endocrinol Metab,AP HP, 47-83 Blvd Hop, F-75651 Paris, France.
EM philippe.giral@psl.aphp.fr
RI chapman, john/Y-2742-2019
OI Carrie, Alain/0000-0003-4726-1171
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NR 56
TC 45
Z9 49
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1079-5642
EI 1524-4636
J9 ARTERIOSCL THROM VAS
JI Arterioscler. Thromb. Vasc. Biol.
PD MAR
PY 2008
VL 28
IS 3
BP 587
EP 593
DI 10.1161/ATVBAHA.107.157891
PG 7
WC Hematology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Hematology; Cardiovascular System & Cardiology
GA 266IZ
UT WOS:000253429000037
PM 18202323
OA Bronze
DA 2025-06-11
ER

PT J
AU Janicke, DM
   Harman, JS
   Kelleher, KJ
   Zhang, JY
AF Janicke, David M.
   Harman, Jeffrey S.
   Kelleher, Kelly J.
   Zhang, Jianyi
TI Psychiatric diagnosis in children and adolescents with obesity-related
   health conditions
SO JOURNAL OF DEVELOPMENTAL AND BEHAVIORAL PEDIATRICS
LA English
DT Article
DE children; obesity; psychiatric diagnosis; chronic illness
ID PSYCHOLOGICAL ADJUSTMENT; PSYCHOSOCIAL ADJUSTMENT; GLUCOSE-METABOLISM;
   DIABETES-MELLITUS; PHYSICAL-ACTIVITY; WEIGHT STATUS; YOUNG-ADULTS;
   RISK-FACTORS; CARE USE; OVERWEIGHT
AB Objective: Childhood obesity is linked with a number of problematic health conditions. While data suggest that children who are obese are at increased risk of psychosocial distress relative to nonobese peers, there are limited data outlining the rates of psychiatric diagnoses in children with obesity-related health conditions such as type 2 diabetes and the metabolic syndrome. Methods: This study used Medicaid claims data from the State of Florida to compare the rates of psychiatric diagnoses for children with obesity-related health conditions, aged 5 to 18 years, to those of children with comparison chronic health conditions. Results: Overall, 35% of children with an obesity-related diagnosis had a psychiatric diagnosis. While controlling for age, gender, and race, youths with type 2 diabetes, the metabolic syndrome, and dyslipidemia had higher rates of International Classification of Disease, Ninth Revision (ICD-9) psychiatric diagnoses than children with cystic fibrosis, sickle cell disease, and juvenile rheumatoid arthritis (p < .001), but similar to those of children with asthma. Non-Hispanic white children with an obesity-related health condition had greater odds of receiving a psychiatric diagnosis than African American (odds ratio [OR] = 0.54, p < .001) or Hispanic (OR = 0.41, p < .001) children. Males and females differed in rates of externalizing and internalizing diagnoses. Conclusions:The data suggest that children with an obesity-related health condition have higher rates of internalizing and externalizing mental health conditions relative to children with other chronic health conditions. Prospective, longitudinal research is needed to further confirm these findings and examine factors that affect this association and potential impacts on the health care system.
C1 [Janicke, David M.] Univ Florida, Dept Clin & Hlth Psychol, Gainesville, FL 32610 USA.
   [Harman, Jeffrey S.] Univ Florida, Dept Hlth Serv Res Management & Policy, Gainesville, FL 32610 USA.
   [Kelleher, Kelly J.] Childrens Hosp, Dept Pediat & Publ Hlth, Columbus, OH 43205 USA.
   [Zhang, Jianyi] Univ Florida, Ctr Medicaid & Uninsured, Gainesville, FL 32610 USA.
C3 State University System of Florida; University of Florida; State
   University System of Florida; University of Florida; University System
   of Ohio; Ohio State University; Nationwide Childrens Hospital; State
   University System of Florida; University of Florida
RP Janicke, DM (corresponding author), Univ Florida, Dept Clin & Hlth Psychol, POB 100165, Gainesville, FL 32610 USA.
EM djanicke@phhp.ufl.edu
RI Kelleher, Kelly/E-3361-2011
OI Zhang, Jianyi/0000-0002-1501-4822; Janicke, David/0000-0002-8493-610X
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NR 39
TC 33
Z9 41
U1 0
U2 12
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0196-206X
EI 1536-7312
J9 J DEV BEHAV PEDIATR
JI J. Dev. Behav. Pediatr.
PD AUG
PY 2008
VL 29
IS 4
BP 276
EP 284
DI 10.1097/DBP.0b013e31817102f8
PG 9
WC Behavioral Sciences; Psychology, Developmental; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Behavioral Sciences; Psychology; Pediatrics
GA 337CA
UT WOS:000258411900008
PM 18562982
DA 2025-06-11
ER

PT J
AU Moorehead, NR
   Goodie, JL
   Krantz, DS
AF Moorehead, Nicholas R.
   Goodie, Jeffrey L.
   Krantz, David S.
TI Prospective Bidirectional Relations Between Depression and Metabolic
   Health: 30-Year Follow-Up From the National Heart, Lung, and Blood
   Institute (NHLBI) Coronary Artery Disease in Young Adults (CARDIA) Study
SO HEALTH PSYCHOLOGY
LA English
DT Article
DE metabolic syndrome; depressive symptoms; race; sex; longitudinal study
ID RISK DEVELOPMENT; CIGARETTE-SMOKING; MAJOR DEPRESSION; UNITED-STATES;
   SYMPTOMS; ASSOCIATION; INFLAMMATION; POPULATION; OBESITY; SEX
AB Objective: This study investigated prospective bidirectional relationships between depressive symptoms and metabolic syndrome (MetS) and the moderating effects of race, sex, and health behaviors in a diverse cohort followed for 30 years. Method: Data were analyzed from the National Heart, Lung, and Blood Institute (NHLBI) Coronary Artery Disease in Young Adults (CARDIA) study, a 30-year prospective study of young adults (N = 5,113; M-age = 24.76 [SD = 3.63] at baseline; 45% male) who were tested every 5 years between 1985 and 2015. Measures included biological assessments of MetS components and self-reported depressive symptoms based on the Center for Epidemiologic Studies Depression (CESD) scale. Data analyses included bidirectional general estimating equations analyses of time-lagged associations between depressive symptoms and MetS. Results: There was a consistent, bidirectional relationship between depressive symptoms and MetS over time. Individuals with more CESD depressive symptoms were more likely to develop MetS over time compared to those reporting fewer symptoms, Wald chi(2)(1) = 7.09, p < .008, and MetS was similarly predictive of CESD. MetS more consistently predicted CESD scores at each 5-year exam than CESD predicted MetS. Race and sex moderated these relationships, with White females, White individuals overall, and females overall demonstrating significant relationships between CESD depressive symptoms and MetS. Health behaviors were not related to associations between CESD and MetS. Conclusion: In a diverse young adult population prospectively followed into late middle age, MetS more consistently predicted depressive symptoms over time than depressive symptoms predicted MetS. The relation between MetS and depressive symptoms was moderated by race and sex, but not health behaviors.
C1 [Moorehead, Nicholas R.] US Air Force, Eielson AFB, Operat Med Readiness Grp 354, 2630 Cent Ave, Eielson Afb, AK 99702 USA.
   [Moorehead, Nicholas R.; Goodie, Jeffrey L.; Krantz, David S.] Uniformed Serv Univ Hlth Sci, Sch Med, Dept Med & Clin Psychol, Bethesda, MD USA.
   [Goodie, Jeffrey L.] Uniformed Serv Univ Hlth Sci, Sch Med, Dept Family Med, Bethesda, MD USA.
C3 United States Department of Defense; United States Air Force; Uniformed
   Services University of the Health Sciences - USA; Uniformed Services
   University of the Health Sciences - USA
RP Moorehead, NR (corresponding author), US Air Force, Eielson AFB, Operat Med Readiness Grp 354, 2630 Cent Ave, Eielson Afb, AK 99702 USA.
EM nicholas.r.moorehead.mil@health.mil
RI Krantz, David/L-5364-2015; Goodie, Jeffrey/AAU-1318-2020
OI Krantz, David/0000-0002-1671-1355
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NR 50
TC 2
Z9 2
U1 0
U2 39
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 0278-6133
EI 1930-7810
J9 HEALTH PSYCHOL
JI Health Psychol.
PD APR
PY 2024
VL 43
IS 4
BP 259
EP 268
DI 10.1037/hea0001339
EA DEC 2023
PG 10
WC Psychology, Clinical; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology
GA H7I7O
UT WOS:001126023600001
PM 38095973
DA 2025-06-11
ER

PT J
AU Enko, D
   Brandmayr, W
   Halwachs-Baumann, G
   Schnedl, WJ
   Meinitzer, A
   Kriegshäuser, G
AF Enko, Dietmar
   Brandmayr, Wolfgang
   Halwachs-Baumann, Gabriele
   Schnedl, Wolfgang J.
   Meinitzer, Andreas
   Kriegshaeuser, Gernot
TI Prospective plasma lipid profiling in individuals with and without
   depression
SO LIPIDS IN HEALTH AND DISEASE
LA English
DT Article
DE Biomarkers; Cholesterol; Depression; Lipids; Triglycerides
ID CORONARY-HEART-DISEASE; METABOLIC SYNDROME; SERUM-CHOLESTEROL; MAJOR
   DEPRESSION; CARDIOVASCULAR-DISEASE; BIPOLAR DISORDER; RISK-FACTOR; MEN;
   POPULATION; SYMPTOMS
AB Background: So far, studies on possible association of plasma lipid levels and depressive disorder are contradictory. This prospective work aimed at assessing a plasma lipid profile in individuals with major depression and healthy controls.
   Methods: In total, 94 patients with major depression and 152 healthy controls were included in this prospective study. After an overnight fasting state of 12 h they underwent blood drawing for triglyzerides (TG), total cholesterol, low-density lipoprotein (LDL)- and high-density lipoprotein (HDL)-cholesterol measurements. All participants were evaluated in a clinical interview and filled out the self-rating Beck Depression Inventory (BDI-II) scale to identify depressive symptomatology.
   Results: Ninety-four patients with major depression showed significantly higher median (interquartile range) plasma TG levels (108.0 [75.8-154.1] vs. 84.0 [63.0-132.2] mg/dL, P = 0.014) and significantly lower HDL-cholesterol levels (55.0 [46.9-123.0] vs. 61.5 [47.4-72.6] mg/dL, P = 0.049) compared to 152 individuals without depression, respectively. Total and LDL-cholesterol concentrations were observed slightly higher in patients with major depression. Significant positive correlation was found between TG, total cholesterol and LDL-cholesterol concentrations and the BDI-II score (p = 0.027, 0.048 and 0.018), and in tendency negative correlation between HDL-cholesterol levels and the BDI-II score (P = 0.091), respectively.
   Conclusions: Depressive individuals were found with adverse plasma lipid patterns of higher TG and lower HDL-cholesterol levels compared to healthy controls. On this basis, the authors would suggest the implementation of routine lipid measurements in order to stratify these patients by their cardiovascular risk.
C1 [Enko, Dietmar; Halwachs-Baumann, Gabriele; Kriegshaeuser, Gernot] Gen Hosp Steyr, Inst Clin Chem & Lab Med, Sierningerstr 170, A-400 Steyr, Austria.
   [Enko, Dietmar; Meinitzer, Andreas; Kriegshaeuser, Gernot] Med Univ Graz, Clin Inst Med & Chem Lab Diagnost, Auenbruggerpl 15, A-8036 Graz, Austria.
   [Brandmayr, Wolfgang] Gen Hosp Steyr, Dept Psychiat & Psychotherapeut Med, Sierningerstr 170, A-400 Steyr, Austria.
   [Schnedl, Wolfgang J.] Practice Gen Internal Med, Dr Theodor Korner Str 19b, A-8600 Bruck Mur, Austria.
C3 Medical University of Graz
RP Enko, D (corresponding author), Gen Hosp Steyr, Inst Clin Chem & Lab Med, Sierningerstr 170, A-400 Steyr, Austria.; Enko, D (corresponding author), Med Univ Graz, Clin Inst Med & Chem Lab Diagnost, Auenbruggerpl 15, A-8036 Graz, Austria.
EM dietmar.enko@gespag.at
OI Schnedl, Wolfgang/0000-0002-5212-5230
CR Äijänseppä S, 2002, INT J GERIATR PSYCH, V17, P629, DOI 10.1002/gps.666
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NR 26
TC 49
Z9 52
U1 1
U2 9
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1476-511X
J9 LIPIDS HEALTH DIS
JI Lipids Health Dis.
PD JUN 26
PY 2018
VL 17
AR 149
DI 10.1186/s12944-018-0796-3
PG 6
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA GL2WE
UT WOS:000436985800001
PM 29945617
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Ayuthaya, BIN
   Lertpimonchai, A
   Samaranayake, L
   Vathesatogkit, P
   Thienpramuk, L
   Wisitrasameewong, W
   Tamsailom, S
AF Ayuthaya, Benjar Issaranggun Na
   Lertpimonchai, Attawood
   Samaranayake, Lakshman
   Vathesatogkit, Prin
   Thienpramuk, Lalitsara
   Wisitrasameewong, Wichaya
   Tamsailom, Suphot
TI The Potential Effect of Periodontal Disease on the Development of
   Metabolic Syndrome: A 10-Year Observational Study in a Thai Adult Cohort
SO JOURNAL OF CLINICAL PERIODONTOLOGY
LA English
DT Article
DE longitudinal studies; metabolic syndrome; periodontal diseases;
   periodontitis
ID CARDIOVASCULAR-DISEASE; OXIDATIVE STRESS; ASSOCIATION; PREVALENCE;
   INFLAMMATION; POPULATION; SURVEILLANCE; MARKERS; RISK; AGE
AB AimAs data are sparse on the long-term association between periodontal diseases and development of metabolic syndrome (MetS), we investigated their relationship in a Thai cohort over a 10-year observational period.MethodsMedical records and data on periodontal assessments of 2161 employees of the Electricity Generating Authority of Thailand collected at two time points, 2003 and 2013, were used. Experienced periodontists used standard national and international criteria to define periodontitis and MetS. The impact of baseline periodontitis on subsequent MetS incidence and its components was evaluated using regression analyses.ResultsThe severity and extent of periodontitis significantly predicted MetS incidence over a decade, with a higher incidence of MetS in individuals with poorer periodontal health. A single percentage increase in the periodontitis extent raised the risk of MetS incidence by 0.4% and the risk of developing individual components of MetS by 0.2%. Independent of periodontal health, age of an individual emerged as a factor impacting MetS development.ConclusionThis study highlights the potential effect of the severity and extent of periodontitis on the increased incidence and progression of MetS. Hyperglycaemia and hypertension were the two MetS components most significantly affected by the existence of periodontitis.
C1 [Ayuthaya, Benjar Issaranggun Na; Lertpimonchai, Attawood; Samaranayake, Lakshman; Wisitrasameewong, Wichaya; Tamsailom, Suphot] Chulalongkorn Univ, Fac Dent, Ctr Excellence Periodontal Dis & Implant Dent, Dept Periodontol, Bangkok, Thailand.
   [Samaranayake, Lakshman] Univ Hong Kong, Fac Dent, Pok Fu Lam, Hong Kong, Peoples R China.
   [Vathesatogkit, Prin] Mahidol Univ, Ramathibodi Hosp, Fac Med, Bangkok, Thailand.
   [Thienpramuk, Lalitsara] Elect Generating Author Thailand, Med & Hlth Dept, Hlth Div, Nonthaburi, Thailand.
C3 Chulalongkorn University; University of Hong Kong; Mahidol University
RP Tamsailom, S (corresponding author), Chulalongkorn Univ, Fac Dent, Ctr Excellence Periodontal Dis & Implant Dent, Dept Periodontol, Bangkok, Thailand.
EM suphot.t@chula.ac.th
RI Samaranayake, Lakshman/K-4947-2018
OI Lertpimonchai, Attawood/0000-0003-2501-1534; Tamsailom,
   Suphot/0000-0001-6843-5885
FU Thailand Research Fund; Chulalongkorn Academic Advancement into its 2nd
   Century Project (CUAASC); Thai Health Promotion Foundation [99/8];
   Chulalongkorn University, second century (C2) high potential
   professoriate fund at its Faculty of Dentistry
FX We would like to thank the staff of Ramathibodi Hospital and the
   Department of Periodontology, Chulalongkorn University, who contributed
   to the survey and data collection Additionally, we extend our thanks to
   Associate Prof. Orawan Charatkulangkun and Prof. Piyamitr Sritara for
   their valuable contributions to study design and data interpretation.
   This study was supported by the Chulalongkorn Academic Advancement into
   its 2nd Century Project (CUAASC) (Chamchuri 5 Building 6th Floor,
   Phayathai Road, Pathumwan, Bangkok 10330, Thailand), Thailand Research
   Fund and Thai Health Promotion Foundation (Thai Health Centre, 99/8, Soi
   Ngamduplee, Thung Maha Mek, Sathorn, Bangkok 10120, Thailand). Lakshman
   Samaranayake was supported by the Chulalongkorn University, second
   century (C2) high potential professoriate fund at its Faculty of
   Dentistry.
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NR 48
TC 3
Z9 3
U1 1
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0303-6979
EI 1600-051X
J9 J CLIN PERIODONTOL
JI J. Clin. Periodontol.
PD MAR
PY 2025
VL 52
IS 3
BP 339
EP 352
DI 10.1111/jcpe.14068
EA SEP 2024
PG 14
WC Dentistry, Oral Surgery & Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dentistry, Oral Surgery & Medicine
GA X1J5E
UT WOS:001308945200001
PM 39256912
OA hybrid
DA 2025-06-11
ER

PT J
AU Deng, ZZ
   Wang, J
   Wu, N
   Geng, LH
   Zhang, QB
   Yue, Y
AF Deng, Zhenzhen
   Wang, Jing
   Wu, Ning
   Geng, Lihua
   Zhang, Quanbin
   Yue, Yang
TI Co-activating the AMPK signaling axis by low molecular weight fucoidan
   LF2 and fucoxanthin improves the HFD-induced metabolic syndrome in mice
SO JOURNAL OF FUNCTIONAL FOODS
LA English
DT Article
DE Fucoxanthin; Fucoidan; Metabolic Syndrome; AMPK Signaling Axis
ID INSULIN-RESISTANCE; DOWN-REGULATION; ADIPOCYTE DIFFERENTIATION; FATTY
   LIVER; PPAR-GAMMA; ADIPOGENESIS; GLUCOSE; MODEL; DIET
AB Metabolic syndrome (MetS) is a pathological condition characterized by multiple metabolic abnormalities. With the global epidemic of obesity and diabetes, MetS needs more urgent treatments and interventions. Fucoxanthin (FX) and fucoidan are two important active components derived from brown algae, which have been recommended as adjunctive therapy for MetS. In this study, we found that FX and low molecular weight fucoidan fraction LF2 improved insulin resistance (IR) and enhanced insulin sensitivity in high fat diet (HFD)-induced MetS mice synergistically. LF2 and FX could ameliorate HFD-induced liver injury by reducing liver fat deposition, inflammatory response and oxidative stress. Adenosine 5'-monophosphate-activated protein kinase (AMPK) signaling axis is a key target for LF2 and FX to improve MetS. FX and LF2 reduced adipogenesis and conversion through co-activation of AMPK and reduction of the expression of adipogenic differentiation factors. In addition, FX up-regulated the expression of uncoupling protein (UCP-1) and promoted the body's energy expenditure. However, LF2 did not significantly increase the anti-hyperlipidemic effect of FX. Collectively, this study elucidated the synergistic improvement of MetS by FX and LF2 from a molecular perspective. It also demonstrated the potential of fucoxanthin combined with fucoidan as an anti-MetS functional food.
C1 [Deng, Zhenzhen; Wang, Jing; Wu, Ning; Geng, Lihua; Zhang, Quanbin; Yue, Yang] Inst Oceanol, Chinese Acad Sci, Ctr Ocean Mega Sci, Shandong Prov Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China.
   [Deng, Zhenzhen; Wang, Jing; Wu, Ning; Geng, Lihua; Zhang, Quanbin; Yue, Yang] Lab Marine Biol & Biotechnol, Qingdao Natl Lab Marine Sci & Tech, Qingdao 266071, Peoples R China.
   [Deng, Zhenzhen; Zhang, Quanbin] Univ Chinese Acad Sci, Beijing 100049, Peoples R China.
   [Deng, Zhenzhen; Wang, Jing; Wu, Ning; Geng, Lihua; Zhang, Quanbin; Yue, Yang] Chinese Acad Sci, CAS, Qingdao 266071, Peoples R China.
C3 Chinese Academy of Sciences; Institute of Oceanology, CAS; Laoshan
   Laboratory; Chinese Academy of Sciences; University of Chinese Academy
   of Sciences, CAS; Chinese Academy of Sciences
RP Yue, Y (corresponding author), Inst Oceanol, Chinese Acad Sci, Ctr Ocean Mega Sci, Shandong Prov Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China.; Yue, Y (corresponding author), Chinese Acad Sci, CAS, Qingdao 266071, Peoples R China.
EM yueyang@qdio.ac.cn
RI Zhang, Quanbin/IUQ-3663-2023
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NR 41
TC 2
Z9 2
U1 5
U2 38
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1756-4646
EI 2214-9414
J9 J FUNCT FOODS
JI J. Funct. Food.
PD JUL
PY 2022
VL 94
AR 105119
DI 10.1016/j.jff.2022.105119
EA MAY 2022
PG 9
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA 1Y0QN
UT WOS:000807851100001
OA gold
DA 2025-06-11
ER

PT J
AU Navarrete, C
   Garcia-Martin, A
   DeMesa, J
   Muñoz, E
AF Navarrete, Carmen
   Garcia-Martin, Adela
   DeMesa, Jim
   Munoz, Eduardo
TI Cannabinoids in Metabolic Syndrome and Cardiac Fibrosis
SO CURRENT HYPERTENSION REPORTS
LA English
DT Review
DE Cannabinoids; Endocannabinoid system; Metabolic syndrome; Cardiovascular
   disease; Cardiac fibrosis
ID RECEPTOR ANTAGONIST TM38837; MUSCLE-CELL PROLIFERATION; ENDOCANNABINOID
   SYSTEM; MOLECULAR CHARACTERIZATION; MYOCARDIAL-INFARCTION; MONOGLYCERIDE
   LIPASE; OXIDATIVE STRESS; GENETIC ABLATION; INFLAMMATION; INHIBITION
AB Purpose of Review This article provides a concise overview of how cannabinoids and the endocannabinoid system (ECS) have significant implications for the prevention and treatment of metabolic syndrome (MetS) and for the treatment of cardiovascular disorders, including cardiac fibrosis. Recent Findings Over the past few years, the ECS has emerged as a pivotal component of the homeostatic mechanisms for the regulation of many bodily functions, including inflammation, digestion, and energy metabolism. Therefore, the pharmacological modulation of the ECS by cannabinoids represents a novel strategy for the management of many diseases. Specifically, increasing evidence from preclinical research studies has opened new avenues for the development of cannabinoid-based therapies for the management and potential treatment of MetS and cardiovascular diseases. Current information indicates that modulation of the ECS can help maintain overall health and well-being due to its homeostatic function. From a therapeutic perspective, cannabinoids and the ECS have also been shown to play a key role in modulating pathophysiological states such as inflammatory, neurodegenerative, gastrointestinal, metabolic, and cardiovascular diseases, as well as cancer and pain. Thus, targeting and modulating the ECS with cannabinoids or cannabinoid derivatives may represent a major disease-modifying medical advancement to achieve successful treatment for MetS and certain cardiovascular diseases.
C1 [Navarrete, Carmen; Garcia-Martin, Adela; DeMesa, Jim] Emerald Hlth Pharmaceut, San Diego, CA USA.
   [Munoz, Eduardo] Univ Cordoba, Inst Maimonides Invest Biomed Cordoba, Avda Menendez Pidal S-N, Cordoba 14004, Spain.
   [Munoz, Eduardo] Univ Cordoba, Dept Biol Celular Fisiol & Inmunol, Cordoba, Spain.
   [Munoz, Eduardo] Hosp Univ Reina Sofia, Cordoba, Spain.
C3 Universidad de Cordoba; Universidad de Cordoba; Hospital Universitario
   Reina Sofia - Cordoba
RP Muñoz, E (corresponding author), Univ Cordoba, Inst Maimonides Invest Biomed Cordoba, Avda Menendez Pidal S-N, Cordoba 14004, Spain.; Muñoz, E (corresponding author), Univ Cordoba, Dept Biol Celular Fisiol & Inmunol, Cordoba, Spain.; Muñoz, E (corresponding author), Hosp Univ Reina Sofia, Cordoba, Spain.
EM filmuble@uco.es
RI Munoz, Eduardo/I-5225-2012
OI Navarrete, Carmen Maria/0000-0003-1438-9216; GARCIA MARTIN, ADELA
   MARIA/0000-0001-7054-7907; Munoz, Eduardo/0000-0001-8478-5842
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NR 98
TC 8
Z9 9
U1 0
U2 7
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1522-6417
EI 1534-3111
J9 CURR HYPERTENS REP
JI Curr. Hypertens. Rep.
PD OCT 21
PY 2020
VL 22
IS 12
AR 98
DI 10.1007/s11906-020-01112-7
PG 10
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA OL1JZ
UT WOS:000585099200001
PM 33089434
DA 2025-06-11
ER

PT J
AU Leonardi, BF
   Gosmann, G
   Zimmer, AR
AF Leonardi, Bianca F.
   Gosmann, Grace
   Zimmer, Aline R.
TI Modeling Diet-Induced Metabolic Syndrome in Rodents
SO MOLECULAR NUTRITION & FOOD RESEARCH
LA English
DT Review
DE C57BL; 6 mice; hypercaloric diets; metabolic syndrome; obesity; rodent
   models
ID HIGH-FAT-DIET; INDUCED INSULIN-RESISTANCE; HEPATIC LIPID-ACCUMULATION;
   ADIPOSE-TISSUE INFLAMMATION; INDUCED KIDNEY INJURY; INDUCED OBESITY;
   LIVER-DISEASE; OXIDATIVE STRESS; C57BL/6 MICE; ETHANOL EXTRACT
AB Standardized animal models represent one of the most valuable tools available to understand the mechanism underlying the metabolic syndrome (MetS) and to seek for new therapeutic strategies. However, there is considerable variability in the studies conducted with this essential purpose. This review presents an updated discussion of the most recent studies using diverse experimental conditions to induce MetS in rodents with unbalanced diets, discusses the key findings in metabolic outcomes, and critically evaluates what we have been learned from them and how to advance in the field. The study includes scientific reports sourced from the Web of Science and PubMed databases, published between January 2013 and June 2020, which used hypercaloric diets to induce metabolic disorders, and address the impact of the diet on metabolic parameters. The collected data are used as support to discuss variables such as sex, species, and age of the animals, the most favorable type of diet, and the ideal diet length to generate metabolic changes. The experimental characteristics propose herein improve the performance of a preclinical model that resembles the human MetS and will guide researchers to investigate new therapeutic alternatives with confidence and higher translational validity.
C1 [Leonardi, Bianca F.; Gosmann, Grace; Zimmer, Aline R.] Fed Univ Rio Grande do Sul UFRGS, Fac Pharm, Phytochem & Organ Synth Lab, Pharmaceut Sci Grad Program, 2752 Ipiranga Ave, BR-90610000 Porto Alegre, RS, Brazil.
C3 Universidade Federal do Rio Grande do Sul
RP Zimmer, AR (corresponding author), Fed Univ Rio Grande do Sul UFRGS, Fac Pharm, Phytochem & Organ Synth Lab, Pharmaceut Sci Grad Program, 2752 Ipiranga Ave, BR-90610000 Porto Alegre, RS, Brazil.
EM aline.zimmer@ufrgs.br
RI Zimmer, Aline/A-3330-2016; Leonardi, Bianca/KIJ-7747-2024; Gosmann,
   Grace/AAJ-9760-2020; Gosmann, Grace/G-3331-2012
OI Franco Leonardi, Bianca/0000-0002-9777-9975; Gosmann,
   Grace/0000-0001-6823-8312
FU Conselho Nacional de Desenvolvimento Cientifico e Tecnologico-CNPq;
   Fundacao de Amparo a Pesquisa do Rio Grande do Sul-FAPERGS; Coordenacao
   de Aperfeicoamento de Pessoal de Nivel Superior-CAPES; Graduate Program
   of Pharmaceutical Sciences-PPGCF/UFRGS
FX This work was supported by Conselho Nacional de Desenvolvimento
   Cientifico e Tecnologico-CNPq; Fundacao de Amparo a Pesquisa do Rio
   Grande do Sul-FAPERGS; Coordenacao de Aperfeicoamento de Pessoal de
   Nivel Superior-CAPES; and Graduate Program of Pharmaceutical
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NR 343
TC 19
Z9 21
U1 1
U2 30
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1613-4125
EI 1613-4133
J9 MOL NUTR FOOD RES
JI Mol. Nutr. Food Res.
PD NOV
PY 2020
VL 64
IS 22
AR 2000249
DI 10.1002/mnfr.202000249
EA OCT 2020
PG 23
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA PA5EG
UT WOS:000575943800001
PM 32978870
DA 2025-06-11
ER

PT J
AU Jung, JG
   Kim, JS
   Yoon, SJ
   Oh, MK
AF Jung, Jin-Gyu
   Kim, Jong-Sung
   Yoon, Seok-Joon
   Oh, Mi-Kyeong
TI Relationships Among Alcohol Consumption, Facial Flushing Response, and
   Metabolic Syndrome in Healthy Men
SO ANNALS OF EPIDEMIOLOGY
LA English
DT Article
DE Drinking; Flushing Response; Metabolic Syndrome
ID CORONARY-HEART-DISEASE; ALDEHYDE DEHYDROGENASE-2; LIPOPROTEIN
   SUBCLASSES; OXIDATIVE STRESS; BLOOD-PRESSURE; JAPANESE MEN; RISK;
   DRINKING; WOMEN; HYPERTENSION
AB PURPOSE: It is believed that alcohol has an intimate connection with metabolic syndrome (MS). However, the role of facial flushing after alcohol consumption in this relationship has not yet been well known. We explored the relationship between weekly alcohol consumption, risk of MS, and the flushing response.
   METHODS: The subjects were 1823 Korean adult males (305 nondrinkers, 540 flushers, 978 nonflushers) who had undergone a comprehensive medical check-up at Chungnam National University Hospital. We excluded the cases with the history of hypertension, diabetes, dyslipidemia, or who had taken medication in the previous month. After controlling for age, body mass index, exercise status, and smoking history, we used a logistic regression analysis to calculate the risk of MS with drinks per week in flushers and nonflushers as compared with nondrinkers.
   RESULTS: The risk of MS in flushers was significantly increased with alcohol consumption >4 drinks (4-16 drinks: odds ratio [OR] 1.93; > 16 drinks: OR 2.20). However, in nonflushers, the risk of MS was increased in those consuming > 16 drinks (OR 2.02).
   CONCLUSIONS: Our results suggest that the threshold for MS from alcohol consumption is lower in flushers than in nonflushers. Ann Epidemiol 2012;22:480-486. (C) 2012 Elsevier Inc. All rights reserved.
C1 [Jung, Jin-Gyu; Kim, Jong-Sung; Yoon, Seok-Joon] Chungnam Natl Univ, Coll Med, Res Inst Med Sci, Dept Family Med, Taejon, South Korea.
   [Oh, Mi-Kyeong] Univ Ulsan, Coll Med, Gangneung Asan Hosp, Dept Family Med, Ulsan 680749, South Korea.
C3 Chungnam National University; University of Ulsan
RP Kim, JS (corresponding author), Chungnam Natl Univ Hosp, Dept Family Med, 640 Daesa Dong, Taejon 301721, South Korea.
EM josephkim@cnu.ac.kr
RI ; Kim, Seok-Hwan/G-9981-2015
OI Yoon, SeokJoon/0000-0002-6784-8191; Kim, Jong-Sung/0000-0001-5945-0784;
   Kim, Seok-Hwan/0000-0003-0209-0444
FU Chungnam National University Hospital
FX This research was supported by Chungnam National University Hospital
   Research Fund, 2010.
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NR 38
TC 19
Z9 19
U1 0
U2 7
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1047-2797
EI 1873-2585
J9 ANN EPIDEMIOL
JI Ann. Epidemiol.
PD JUL
PY 2012
VL 22
IS 7
BP 480
EP 486
DI 10.1016/j.annepidem.2012.04.014
PG 7
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA 959GT
UT WOS:000305301600004
PM 22575812
DA 2025-06-11
ER

PT J
AU Copeland, WE
   Shanahan, L
   Worthman, C
   Angold, A
   Costello, EJ
AF Copeland, William E.
   Shanahan, Lilly
   Worthman, Carol
   Angold, Adrian
   Costello, E. Jane
TI Cumulative Depression Episodes Predict Later C-Reactive Protein Levels:
   A Prospective Analysis
SO BIOLOGICAL PSYCHIATRY
LA English
DT Article
DE Adolescence; childhood; CRP; depression; epidemiology; inflammation
ID CORONARY-HEART-DISEASE; CARDIOVASCULAR RISK; METABOLIC SYNDROME;
   INFLAMMATION; PREVENTION; SYMPTOMS; HEALTH; CHILD; ASSOCIATIONS;
   PREVALENCE
AB Background: Depression is associated with elevated levels of the inflammation marker C-reactive protein (CRP); yet, the direction of this association remains unclear. This study tested bi-directional longitudinal associations between CRP and depression in a sample of adolescents and young adults. The study compared the effect of current depression with the effect of cumulative episodes of depression over time.
   Methods: Nine waves of data from the prospective population-based Great Smoky Mountains Study (n = 1420) were used, covering children in the community aged 9 to 16, 19, and 21 years old. Structured interviews were used to assess depressive symptoms, depression diagnosis, and cumulative depressive episodes. Bloodspots were collected at each observation and assayed for CRP levels.
   Results: CRP levels were not associated with later depression status. In contrast, all depression-related variables displayed evidence of association with later CRP levels. The associations with depressive symptoms and diagnostic status were attenuated after controlling for covariates, particularly body mass index, smoking, and medication use. The effect of cumulative depressive episodes, however, continued to be significant after accounting for a range of covariates. Body mass index, smoking behavior, and recent infections may mediate a portion of the effect of cumulative episodes on later CRP, but cumulative depressive episodes continued to predict CRP levels independently.
   Conclusions: The occurrence of multiple depressive episodes exerted the greatest effect on later CRP levels. This suggests that risk for the diseases of middle and old age-cardiovascular and metabolic disease-may begin in childhood and depend, in part, on long-term emotional functioning.
C1 [Copeland, William E.; Angold, Adrian; Costello, E. Jane] Duke Univ, Med Ctr, Dept Psychiat & Behav Sci, Durham, NC 27710 USA.
   [Shanahan, Lilly] Univ N Carolina, Dept Psychol, Greensboro, NC 27412 USA.
   [Worthman, Carol] Emory Univ, Dept Anthropol, Atlanta, GA 30322 USA.
C3 Duke University; University of North Carolina; University of North
   Carolina Greensboro; Emory University
RP Copeland, WE (corresponding author), Duke Univ, Med Ctr, Dept Psychiat & Behav Sci, Box 3454, Durham, NC 27710 USA.
EM William.Copeland@duke.edu
RI Shanahan, Lilly/HNJ-6173-2023; Copeland, William E/N-5413-2014
OI Worthman, Carol M/0000-0002-5397-2298; Shanahan,
   Lilly/0000-0002-4534-6924; Copeland, William E/0000-0002-1348-7781
FU National Institute of Mental Health [MH63970, MH63671, MH48085,
   MH080230, MH094605]; National Institute on Drug Abuse [DA/MH11301];
   National Alliance for Research on Schizophrenia and Depression; William
   T. Grant Foundation
FX The work presented here was supported by the National Institute of
   Mental Health (MH63970, MH63671, MH48085, MH080230, MH094605), the
   National Institute on Drug Abuse (DA/MH11301), National Alliance for
   Research on Schizophrenia and Depression (Early Career Award to first
   author), and the William T. Grant Foundation.
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NR 44
TC 198
Z9 216
U1 1
U2 31
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0006-3223
EI 1873-2402
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD JAN 1
PY 2012
VL 71
IS 1
BP 15
EP 21
DI 10.1016/j.biopsych.2011.09.023
PG 7
WC Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Psychiatry
GA 863BI
UT WOS:000298137400006
PM 22047718
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Grant, RK
   Brindle, WM
   Donnelly, MC
   McConville, PM
   Stroud, TG
   Bandieri, L
   Plevris, JN
AF Grant, Rebecca K.
   Brindle, William M.
   Donnelly, Mhairi C.
   McConville, Pauline M.
   Stroud, Thomas G.
   Bandieri, Lorenzo
   Plevris, John N.
TI Gastrointestinal and liver disease in patients with schizophrenia: A
   narrative review
SO WORLD JOURNAL OF GASTROENTEROLOGY
LA English
DT Review
DE Schizophrenia; Gastrointestinal disease; Liver disease; Mental health
ID SEVERE MENTAL-ILLNESS; CELIAC-DISEASE; HEPATITIS-C; CANCER-MORTALITY;
   RISK-FACTORS; RELAPSED SCHIZOPHRENICS; PSYCHIATRIC-PATIENTS;
   HELICOBACTER-PYLORI; AUTOIMMUNE-DISEASES; METABOLIC SYNDROME
AB Schizophrenia is a severe mental illness which can have a devastating impact on an individual's quality of life. Comorbidities are high amongst patients and life expectancy is approximately 15 years less than the general population. Despite the well-known increased mortality, little is known about the impact of gastrointestinal and liver disease on patients with schizophrenia. We aimed to review the literature and to make recommendations regarding future care. Literature searches were performed on PubMed to identify studies related to gastrointestinal and liver disease in patients with schizophrenia. High rates of chronic liver disease were reported, with Non-Alcoholic Fatty Liver Disease being of particular concern; antipsychotics and metabolic syndrome were contributing factors. Rates of acute liver failure were low but have been associated with antipsychotic use and paracetamol overdose. Coeliac disease has historically been linked to schizophrenia; however, recent research suggests that a causal link is yet to be proven. Evidence is emerging regarding the relationships between schizophrenia and peptic ulcer disease, inflammatory bowel disease and irritable bowel syndrome; clinical vigilance regarding these conditions should be high. Patients with schizophrenia poorly engage with bowel cancer screening programmes, leading to late diagnosis and increased mortality. Clozapine induced constipation is a significant issue for many patients and requires close monitoring. There is a significant burden of gastrointestinal and liver disease amongst patients with schizophrenia. Better levels of support from all members of the medical team are essential to ensure that appropriate, timely care is provided.
C1 [Grant, Rebecca K.; Brindle, William M.; Donnelly, Mhairi C.; Plevris, John N.] Royal Infirm Edinburgh NHS Trust, Ctr Liver & Digest Disorders, Edinburgh EH164SA, Scotland.
   [McConville, Pauline M.; Stroud, Thomas G.; Bandieri, Lorenzo] Royal Edinburgh & Associated Hosp, Gen Adult Psychiat, Edinburgh EH105HF, Scotland.
   [Grant, Rebecca K.] Royal Infirm Edinburgh NHS Trust, Ctr Liver & Digest Disorders, 51 Little France Cres,Old Dalkeith Rd, Edinburgh EH164SA, Scotland.
C3 Royal Infirmary of Edinburgh; Royal Infirmary of Edinburgh; Royal
   Infirmary of Edinburgh
RP Grant, RK (corresponding author), Royal Infirm Edinburgh NHS Trust, Ctr Liver & Digest Disorders, 51 Little France Cres,Old Dalkeith Rd, Edinburgh EH164SA, Scotland.
EM rebecca.x.grant@nhs.scot
RI Plevris, John/O-3517-2014; Grant, Rebecca/JZD-6885-2024
OI Grant, Rebecca/0000-0002-9440-1192
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NR 102
TC 17
Z9 18
U1 0
U2 13
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 7041 Koll Center Parkway, Suite 160, PLEASANTON, CA, UNITED STATES
SN 1007-9327
EI 2219-2840
J9 WORLD J GASTROENTERO
JI World J. Gastroenterol.
PD OCT 14
PY 2022
VL 28
IS 38
BP 5515
EP 5529
DI 10.3748/wjg.v28.i38.5515
PG 15
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 5U4OK
UT WOS:000876528000001
PM 36304087
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Halpern, B
   Mancini, MC
   de Melo, ME
   Lamounier, RN
   Moreira, RO
   Carra, MK
   Kyle, TK
   Cercato, C
   Boguszewski, CL
AF Halpern, Bruno
   Mancini, Marcio C.
   de Melo, Maria Edna
   Lamounier, Rodrigo N.
   Moreira, Rodrigo O.
   Carra, Mario K.
   Kyle, Theodore K.
   Cercato, Cintia
   Boguszewski, Cesar Luiz
TI Proposal of an obesity classification based on weight history: an
   official document by the Brazilian Society of Endocrinology and
   Metabolism (SBEM) and the Brazilian Society for the Study of Obesity and
   Metabolic Syndrome (ABESO)
SO ARCHIVES OF ENDOCRINOLOGY METABOLISM
LA English
DT Article
ID BODY-MASS INDEX; LIFE-STYLE INTERVENTION; ADIPOSE-TISSUE; WAIST
   CIRCUMFERENCE; CARDIOVASCULAR RISK; ENERGY-EXPENDITURE;
   CLINICAL-PRACTICE; AMERICAN-COLLEGE; BARIATRIC SURGERY; OLDER-ADULTS
AB Obesity is a chronic disease associated with impaired physical and mental health. A widespread view in the treatment of obesity is that the goal is to normalize the individual's body mass index (BMI). However, a modest weight loss (usually above 5%) is already associated with clinical improvement, while weight losses of 10%-15% bring even further benefits, independent from the final BMI. The percentage of weight reduction is accepted as a treatment goal since a greater decrease in weight is frequently difficult to achieve due to metabolic adaptation along with environmental and lifestyle factors. In this document, the Brazilian Society of Endocrinology and Metabolism (SBEM) and the Brazilian Society for the Study of Obesity and Metabolic Syndrome (ABESO) propose a new obesity classification based on the maximum weight attained in life (MWAL). In this classification, individuals losing a specific proportion of weight are classified as having "reduced" or "controlled" obesity. This simple classification - which is not intended to replace others but to serve as an adjuvant tool - could help disseminate the concept of clinical benefits derived from modest weight loss, allowing individuals with obesity and their health care professionals to focus on strategies for weight maintenance instead of further weight reduction. In future studies, this proposed classification can also be an important tool to evaluate possible differences in therapeutic outcomes between individuals with similar BMIs but different weight trajectories.
C1 [Halpern, Bruno] Hosp 9 Julho, Ctr Obesidade, Sao Paulo, SP, Brazil.
   [Mancini, Marcio C.; de Melo, Maria Edna; Cercato, Cintia] Univ Sao Paulo, Dept Endocrinol & Metab, Grp Obesidade & Sindrome Metab, Sao Paulo, SP, Brazil.
   [Lamounier, Rodrigo N.] Ctr Diabet Belo Horizonte, Belo Horizonte, MG, Brazil.
   [Moreira, Rodrigo O.] Inst Estadual Diabet & Endocrinol Luiz Capriglion, Rio De Janeiro, RJ, Brazil.
   [Carra, Mario K.] Univ Sao Paulo, Dept Endocrinol, Grp Diabet, Sao Paulo, SP, Brazil.
   [Kyle, Theodore K.] ConscienHealth, Pittsburgh, PA USA.
   [Cercato, Cintia] Assoc Brasileira Estudo Obesidade & Sindrome Meta, Sao Paulo, SP, Brazil.
   [Boguszewski, Cesar Luiz] Univ Fed Parana, Dept Med Interna, Serv Endocrinol & Metabol SEMPR, Curitiba, Parana, Brazil.
   [Boguszewski, Cesar Luiz] Soc Brasileira Endocrinol & Metab SBEM, Sao Paulo, SP, Brazil.
C3 Universidade de Sao Paulo; Universidade de Sao Paulo; Universidade
   Federal do Parana
RP Halpern, B (corresponding author), Rua Alves Guimaraes 462,CJ 72-73, BR-05410000 Sao Paulo, SP, Brazil.
EM brunohalpern@hotmail.com
RI Halpern, Bruno/AAZ-7627-2020; cercato, cintia/O-9163-2017; BOGUSZEWSKI,
   CESAR/D-4603-2013; Moreira, Rodrigo/N-7131-2015; Kyle,
   Theodore/AAE-6625-2020; BOGUSZEWSKI, CESAR LUIZ/V-5661-2019
OI Kyle, Theodore/0000-0003-1119-5854; MELO, MARIA/0000-0002-1216-7532;
   Cercato, Cintia/0000-0002-6181-4951; BOGUSZEWSKI, CESAR
   LUIZ/0000-0001-7285-7941; Moreira, Rodrigo/0000-0003-1561-2926;
   Lamounier, Rodrigo/0000-0001-7432-9085; Halpern,
   Bruno/0000-0003-0973-5065; Correa Mancini, Marcio/0000-0003-1278-0406
FU Brazilian Society of Endocrinology and Metabolism (SBEM); Brazilian
   Society for the Study of Obesity and Metabolic Syndrome (ABESO)
FX the costs of this publication were equally shared by the Brazilian
   Society of Endocrinology and Metabolism (SBEM) and the Brazilian Society
   for the Study of Obesity and Metabolic Syndrome (ABESO) using their own
   resources.
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NR 126
TC 18
Z9 18
U1 0
U2 2
PU SBEM-SOC BRASIL ENDOCRINOLOGIA & METABOLOGIA
PI RIO DE JANEIRO, RJ
PA RUA HUMAITA, 85 CJ 501, RIO DE JANEIRO, RJ, 22261-000, BRAZIL
SN 2359-3997
EI 2359-4292
J9 ARCH ENDOCRIN METAB
JI Arch. Endocrinol. Metab.
PD MAR-APR
PY 2022
VL 66
IS 2
DI 10.20945/2359-3997000000465
PG 13
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 1L0OA
UT WOS:000798991100005
PM 35420271
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Li, CB
   Li, XX
   Chang, Y
   Zhao, L
   Liu, BS
   Wei, SJ
   Xu, F
   Zhang, Y
   Chen, YG
AF Li, Chuanbao
   Li, Xiaoxing
   Chang, Ying
   Zhao, Lang
   Liu, Baoshan
   Wei, Shujian
   Xu, Feng
   Zhang, Yun
   Chen, Yuguo
TI Aldehyde Dehydrogenase-2 Attenuates Myocardial Remodeling and
   Contractile Dysfunction Induced by a High-Fat Diet
SO CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
LA English
DT Article
DE Metabolic syndrome; Myocardial remodeling; Apoptosis; ALDH2; Mice
ID INDUCED METABOLIC SYNDROME; INSULIN-RESISTANCE; LIPOTOXIC
   CARDIOMYOPATHY; OXIDATIVE STRESS; THERAPEUTIC TARGET; OVEREXPRESSION;
   EXPRESSION; OBESITY; PHOSPHORYLATION; HYPERTROPHY
AB Background/Aims: Consumption of a high-fat (HF) diet exacerbates metabolic cardiomyopathy through lipotoxic mechanisms. In this study, we explored the role of aldehyde dehydrogenase-2 (ALDH2) in myocardial damage induced by a HF diet. Methods: Wild-type C57 BL/6J mice were fed a HF diet or control diet for 16 weeks. ALDH2 overexpression was achieved by injecting a lentiviral ALDH2 expression vector into the left ventricle. Results: Consumption of a HF diet induced metabolic syndrome and myocardial remodeling, and these deleterious effects were attenuated by ALDH2 overexpression. In addition, ALDH2 overexpression attenuated the cellular apoptosis and insulin resistance associated with a HF diet. Mechanistically, ALDH2 overexpression inhibited the expression of c-Jun N-terminal kinase (JNK)-1, activated protein 1 (AP-1), insulin receptor substrate 1 (IRS-1), 4-hydroxynonenal, caspase 3, transforming growth factor beta 1, and collagen I and III, and enhanced Akt phosphorylation. Conclusion: ALDH2 may effectively attenuate myocardial remodeling and contractile defects induced by a HF diet through the regulation of the JNK/AP-1 and IRS-1/Akt signaling pathways. Our study demonstrates that ALDH2 plays an essential role in protecting cardiac function from lipotoxic cardiomyopathy. (C) 2018 The Author(s) Published by S. Karger AG, Basel
C1 [Li, Chuanbao; Chang, Ying; Liu, Baoshan; Wei, Shujian; Xu, Feng; Chen, Yuguo] Shandong Univ, Qilu Hosp, Dept Emergency Med, Jinan, Shandong, Peoples R China.
   [Li, Chuanbao; Chang, Ying; Liu, Baoshan; Wei, Shujian; Xu, Feng; Chen, Yuguo] Shandong Univ, Qilu Hosp, Chest Pain Ctr, Jinan, Shandong, Peoples R China.
   [Li, Chuanbao; Chang, Ying; Liu, Baoshan; Wei, Shujian; Xu, Feng; Chen, Yuguo] Shandong Univ, Qilu Hosp, Key Lab Emergency & Crit Care Med Shandong Prov, Jinan, Shandong, Peoples R China.
   [Li, Chuanbao; Li, Xiaoxing; Chang, Ying; Zhao, Lang; Liu, Baoshan; Wei, Shujian; Xu, Feng; Zhang, Yun; Chen, Yuguo] Shandong Univ, Chinese Minist Educ, Key Lab Cardiovasc Remodeling & Funct Res, Jinan, Shandong, Peoples R China.
   [Li, Chuanbao; Li, Xiaoxing; Chang, Ying; Zhao, Lang; Liu, Baoshan; Wei, Shujian; Xu, Feng; Zhang, Yun; Chen, Yuguo] Shandong Univ, Chinese Minist Publ Hlth, Qilu Hosp, Jinan, Shandong, Peoples R China.
   [Li, Xiaoxing] Shandong Univ, Qilu Hosp, Dept Geriatr, Jinan, Shandong, Peoples R China.
C3 Shandong University; Shandong University; Shandong University; Shandong
   University; Ministry of Education - China; Shandong University; Shandong
   University
RP Li, XX; Chen, YG (corresponding author), Shandong Univ, Qilu Hosp, 107 Wenhua Xi Rd, Jinan 250012, Shandong, Peoples R China.
EM lxx2010@126.com; yuguochen@hotmail.com
RI Li, Xiaoxing/B-9114-2008
OI Li, Xiaoxing/0000-0001-8791-7505; Xu, Feng/0000-0002-4670-3727
FU National Natural Science Foundation of China [81400282, 81570401];
   Taishan Scholar Program of Shandong Province [20130911, 20161065]; Fund
   from Department of Science and Technology of Shandong Province
   [2014GGH218004]; China Postdoctoral Science Foundation [2017M612293];
   Shandong Province Postdoctoral Special Fund [201402033]
FX This work was supported by the National Natural Science Foundation of
   China (No. 81400282 and 81570401), the Taishan Scholar Program of
   Shandong Province (No. 20130911 and 20161065), the Fund from Department
   of Science and Technology of Shandong Province (No. 2014GGH218004), the
   China Postdoctoral Science Foundation (No. 2017M612293), and the
   Shandong Province Postdoctoral Special Fund (No. 201402033). We thank
   Nathan Qi and Kavaljit Chhabra at University of Michigan for their
   language assistance.
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NR 34
TC 13
Z9 16
U1 0
U2 11
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1015-8987
EI 1421-9778
J9 CELL PHYSIOL BIOCHEM
JI Cell. Physiol. Biochem.
PY 2018
VL 48
IS 5
BP 1843
EP 1853
DI 10.1159/000492506
PG 11
WC Cell Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Physiology
GA GS5WQ
UT WOS:000443744900003
PM 30092566
OA gold
DA 2025-06-11
ER

PT J
AU Campos-Peña, V
   Toral-Rios, D
   Becerril-Pérez, F
   Sánchez-Torres, C
   Delgado-Namorado, Y
   Torres-Ossorio, E
   Franco-Bocanegra, D
   Carvajal, K
AF Campos-Pena, Victoria
   Toral-Rios, Danira
   Becerril-Perez, Fernando
   Sanchez-Torres, Carmen
   Delgado-Namorado, Yair
   Torres-Ossorio, Elimar
   Franco-Bocanegra, Diana
   Carvajal, Karla
TI Metabolic Syndrome as a Risk Factor for Alzheimer's Disease: Is Aβ a
   Crucial Factor in Both Pathologies?
SO ANTIOXIDANTS & REDOX SIGNALING
LA English
DT Review
DE Alzheimer's disease; metabolic syndrome; amyloid peptide
ID AMYLOID PRECURSOR PROTEIN; INSULIN-DEGRADING ENZYME;
   CENTRAL-NERVOUS-SYSTEM; BLOOD-BRAIN-BARRIER; ANGIOTENSIN-CONVERTING
   ENZYME; GROWTH-FACTOR-I; PAIRED HELICAL FILAMENT; TRANSGENIC MOUSE
   MODEL; CELL-SURFACE RECEPTOR; COGNITIVE DECLINE
AB Significance: Recently, chronic degenerative diseases have become one of the main health problems worldwide. That is the case of Alzheimer's disease (AD) and metabolic syndrome (MetS), whose expression can be influenced by different risk factors.
   Recent Advances: In recent decades, it has been widely described that MetS increases the risk of cognitive impairment and dementia. MetS pathogenesis involves several vascular risk factors such as diabetes, dyslipidemia, hypertension, and insulin resistance (I/R).
   Critical Issues: Reported evidence shows that vascular risk factors are associated with AD, particularly in the development of protein aggregation, inflammation, oxidative stress, neuronal dysfunction, and disturbances in signaling pathways, with insulin receptor signaling being a common alteration between MetS and AD.
   Future Directions: Insulin signaling has been involved in tau phosphorylation and amyloid beta (A beta) metabolism. However, it has also been demonstrated that A beta oligomers can bind to insulin receptors, triggering their internalization, decreasing neuron responsiveness to insulin, and promoting insulin I/R. Thus, it could be argued that A beta could be a convergent factor in the development of both pathologies.
C1 [Campos-Pena, Victoria] Inst Nacl Neurol & Neurocirug, Insurgentes Sur 3877, Mexico City 14269, DF, Mexico.
   [Toral-Rios, Danira] Inst Politecn Nacl, Ctr Invest & Estudios Avanzados, Dept Fisiol Biofis & Neurociencias, Mexico City, DF, Mexico.
   [Becerril-Perez, Fernando; Franco-Bocanegra, Diana] Univ Nacl Autonoma Mexico, Fac Ciencias, Mexico City, DF, Mexico.
   [Sanchez-Torres, Carmen] Inst Politecn Nacl, Ctr Invest & Estudios Avanzados, Dept Biomed Mol, Mexico City, DF, Mexico.
   [Delgado-Namorado, Yair] Univ Autonoma Metropolitana, Mexico City, DF, Mexico.
   [Torres-Ossorio, Elimar] Univ Nacl Autonoma Mexico, Fac Quim, Mexico City, DF, Mexico.
   [Carvajal, Karla] Inst Nacl Pediat, Lab Nutr Expt, Mexico City, DF, Mexico.
C3 CINVESTAV - Centro de Investigacion y de Estudios Avanzados del
   Instituto Politecnico Nacional; Instituto Politecnico Nacional - Mexico;
   Universidad Nacional Autonoma de Mexico; Instituto Politecnico Nacional
   - Mexico; CINVESTAV - Centro de Investigacion y de Estudios Avanzados
   del Instituto Politecnico Nacional; Universidad Autonoma Metropolitana -
   Mexico; Universidad Nacional Autonoma de Mexico
RP Campos-Peña, V (corresponding author), Inst Nacl Neurol & Neurocirug, Insurgentes Sur 3877, Mexico City 14269, DF, Mexico.
EM neurovcp@ymail.com
RI CAMPOS-PEÑA, VICTORIA/AAR-6968-2021; Toral-Rios, Danira/J-7671-2018;
   Sanchez-Torres, Carmen/K-4713-2014
OI CAMPOS-PENA, VICTORIA/0000-0001-8282-7543; Toral-Rios,
   Danira/0000-0001-5156-6969; Sanchez-Torres, Carmen/0000-0003-0045-8233
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NR 233
TC 47
Z9 49
U1 0
U2 18
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1523-0864
EI 1557-7716
J9 ANTIOXID REDOX SIGN
JI Antioxid. Redox Signal.
PD APR
PY 2017
VL 26
IS 10
BP 542
EP +
DI 10.1089/ars.2016.6768
PG 20
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA EP7PX
UT WOS:000397570800004
PM 27368351
DA 2025-06-11
ER

PT J
AU Martins, CC
   Bagatini, MD
   Cardoso, AM
   Zanini, D
   Abdalla, FH
   Baldissarelli, J
   Dalenogare, DP
   Farinha, JB
   Schetinger, MRC
   Morsch, VM
AF Martins, Caroline Curry
   Bagatini, Margarete Dulce
   Cardoso, Andreia Machado
   Zanini, Daniela
   Abdalla, Fatima Husein
   Baldissarelli, Jucimara
   Dalenogare, Diessica Padilha
   Farinha, Juliano Boufleur
   Chitolina Schetinger, Maria Rosa
   Morsch, Vera Maria
TI Regular exercise training reverses ectonucleotidase alterations and
   reduces hyperaggregation of platelets in metabolic syndrome patients
SO CLINICA CHIMICA ACTA
LA English
DT Article
DE Metabolic syndrome; Ectonucleotidases; Exercise training; Platelet
   aggregation
ID ADENINE-NUCLEOTIDE HYDROLYSIS; OXIDATIVE STRESS; SKELETAL-MUSCLE;
   SYNAPTOSOMES; AGGREGATION; NTPDASE; DISEASE; IMPACT; RATS; ATP
AB Background: Alterations in the activity of ectonucleotidase enzymes have been implicated in cardiovascular diseases, whereas regular exercise training has been shown to prevent these alterations. However, nothing is known about it relating to metabolic syndrome (MetS). We investigated the effect of exercise training on platelet ectonucleotidase enzymes and on the aggregation profile of MetS patients.
   Methods: We studied 38 MetS patients who performed regular concurrent exercise training for 30 weeks. Anthropometric measurements, biochemical profiles, hydrolysis of adenine nucleotides in platelets and platelet aggregation were collected from patients before and after the exercise intervention as well as from individuals of the control group.
   Results: An increase in the hydrolysis of adenine nucleotides (ATP, ADP and AMP) and a decrease in adenosine deamination in the platelets of MetS patients before the exercise intervention were observed (P < 0.001). However, these alterations were reversed by exercise training (P < 0.001). Additionally, an increase in platelet aggregation was observed in the MetS patients (P < 0.001) and the exercise training prevented platelet hyperaggregation in addition to decrease the classic cardiovascular risks.
   Conclusions: An alteration of ectonucleotidase enzymes occurs during MetS, whereas regular exercise training had a protective effect on these enzymes and on platelet aggregation. (C) 2016 Elsevier B.V. All rights reserved.
C1 [Martins, Caroline Curry; Bagatini, Margarete Dulce; Cardoso, Andreia Machado; Zanini, Daniela; Abdalla, Fatima Husein; Baldissarelli, Jucimara; Dalenogare, Diessica Padilha; Farinha, Juliano Boufleur; Chitolina Schetinger, Maria Rosa; Morsch, Vera Maria] Univ Fed Santa Maria, Ctr Nat & Exact Sci, Dept Biochem & Mol Biol, Postgrad Program Toxicol Biochem, BR-97119900 Santa Maria, RS, Brazil.
   [Bagatini, Margarete Dulce] Univ Southern Frontier, Collegiate Nursing, Chapeco Campus, SC, Brazil.
   [Farinha, Juliano Boufleur] Univ Fed Santa Maria, Ctr Phys Educ & Sports, Phys Act Grp, BR-97119900 Santa Maria, RS, Brazil.
C3 Universidade Federal de Santa Maria (UFSM); Universidade Federal de
   Santa Maria (UFSM)
RP Morsch, VM (corresponding author), Univ Fed Santa Maria, Ctr Nat & Exact Sci, Dept Biochem & Mol Biol, Postgrad Program Toxicol Biochem, BR-97119900 Santa Maria, RS, Brazil.
EM veramorsch@gmail.com
RI Padilha Dalenogare, Diéssica/IUM-5367-2023; Schetinger,
   Maria/JAC-4640-2023; Cardoso, Andréia/ABH-9732-2020; Morsch,
   Vera/M-6215-2014; Farinha, Juliano/HDN-8796-2022; Zanini,
   Daniela/KEH-7499-2024; Bagatini, Margarete/K-3756-2016; Baldissarelli,
   Jucimara/U-4563-2017
OI Bagatini, Margarete/0000-0001-9263-4980; Boufleur Farinha,
   Juliano/0000-0003-4589-256X; Cardoso, Andreia/0000-0003-4243-8855;
   Chitolina Schetinger, Maria Rosa/0000-0002-5240-8935; Baldissarelli,
   Jucimara/0000-0002-1114-0063; Morsch, Vera Maria/0000-0002-5381-4556
FU Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
   [304641/2013-8]; Fundacao de Amparo a Pesquisa do Rio Grande do Sul
   (FAPERGS) [1279-2551/13-7]; Coordenacao de Aperfeicoamento de Pessoal de
   Nivel Superior (CAPES); FINEP research grant "Rede Institute Brasileiro
   de Neurociencia (IBN-Net)"; "Instituto Nacional de Ciencia e Tecnologia"
   (INCT)
FX The authors wish to thank the Conselho Nacional de Desenvolvimento
   Cientifico e Tecnologico (CNPq: grant number 304641/2013-8), Fundacao de
   Amparo a Pesquisa do Rio Grande do Sul (FAPERGS: grant number
   1279-2551/13-7), Coordenacao de Aperfeicoamento de Pessoal de Nivel
   Superior (CAPES), the FINEP research grant "Rede Institute Brasileiro de
   Neurociencia (IBN-Net)" and "Instituto Nacional de Ciencia e Tecnologia"
   (INCT) for their financial support of this work.
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NR 46
TC 13
Z9 14
U1 0
U2 3
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0009-8981
EI 1873-3492
J9 CLIN CHIM ACTA
JI Clin. Chim. Acta
PD FEB 15
PY 2016
VL 454
BP 66
EP 71
DI 10.1016/j.cca.2015.12.024
PG 6
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA DE0HN
UT WOS:000370305800013
PM 26719035
OA hybrid
DA 2025-06-11
ER

PT J
AU Han, DH
   Lim, S
   Paek, D
   Kim, HD
AF Han, Dong-Hun
   Lim, Sinye
   Paek, Domyung
   Kim, Hyun-Duck
TI Periodontitis could be related factors on metabolic syndrome among
   Koreans: a case-control study
SO JOURNAL OF CLINICAL PERIODONTOLOGY
LA English
DT Article
DE epidemiology; Korean; metabolic syndrome; periodontitis
ID INTERNATIONAL-DIABETES-FEDERATION; BANWOL ENVIRONMENTAL-HEALTH;
   OXIDATIVE STRESS; GLYCEMIC CONTROL; NATIONAL-HEALTH; UNITED-STATES;
   ORAL-HEALTH; NHANES-III; DISEASE; INFLAMMATION
AB Aim: Several studies have suggested that metabolic disorders are related to periodontitis. The objective of this study is to assess whether periodontitis is associated with the metabolic syndrome (MetS) among Koreans.
   Material and Methods: This case-control study was performed among 167 cases with MetS and 166 healthy controls from Shiwha-Banwol Environmental Health Cohort (N = 1853). The community periodontal index (CPI) was used to assess periodontitis (CPI 3-4). MetS was an outcome variable and periodontitis was a main explanatory variable. Age-gender-matched conditional logistic regression models were applied. Monthly household income, smoking, drinking, physical activity and diabetes mellitus were factored as confounders. We also performed stratified analyses according to confounders.
   Results: Those with periodontitis are more likely to be patients with MetS than those without periodontitis. The adjusted odds ratio of periodontitis for MetS was 1.76. There was no significant dose-effect response on the relationship between the number of sextants with periodontitis and MetS. Links became higher in adults aged 45-60 years and adults without diabetes mellitus.
   Conclusions: These results suggest that periodontitis could be an independently related factor on MetS. Hence, dentists and physicians should be aware of the importance of periodontitis as a potential source of inflammatory burden.
C1 [Han, Dong-Hun; Kim, Hyun-Duck] Seoul Natl Univ, Dept Prevent & Social Dent, Sch Dent, Seoul 110749, South Korea.
   [Han, Dong-Hun; Kim, Hyun-Duck] Seoul Natl Univ, Dent Res Inst, Sch Dent, Seoul 110749, South Korea.
   [Lim, Sinye] Kyung Hee Univ, Dept Occupat & Environm Med, Med Ctr, Seoul, South Korea.
   [Paek, Domyung] Seoul Natl Univ, Dept Environm & Occupat Med, Sch Publ Hlth, Seoul 110749, South Korea.
C3 Seoul National University (SNU); Seoul National University (SNU); Kyung
   Hee University; Seoul National University (SNU)
RP Han, DH (corresponding author), Seoul Natl Univ, Dept Prevent & Social Dent, Sch Dent, 28 Yeongeon Dong, Seoul 110749, South Korea.
EM hyundkim@snu.ac.kr
RI Paek, Domyung/D-5747-2012; Han, Dong-Hun/B-2140-2014
FU Ministry of Environment, Korea [90020060032]; Korea Science and
   Engineering Foundation (KOSEF) of the Ministry of Education, Science and
   Technology, Korea [2010-0014141]; National Research Foundation of Korea,
   through the Oromaxillofacial Dysfunction Research Center for the Elderly
   at Seoul National University, Korea [2010-0029479]
FX This work was supported by the grant of the Ministry of Environment,
   Korea (90020060032), the Korea Science and Engineering Foundation
   (KOSEF) grant of the Ministry of Education, Science and Technology,
   Korea (No. 2010-0014141) and the National Research Foundation of Korea
   Grant, through the Oromaxillofacial Dysfunction Research Center for the
   Elderly (No. 2010-0029479) at Seoul National University, Korea.
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NR 47
TC 35
Z9 39
U1 0
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0303-6979
EI 1600-051X
J9 J CLIN PERIODONTOL
JI J. Clin. Periodontol.
PD JAN
PY 2012
VL 39
IS 1
BP 30
EP 37
DI 10.1111/j.1600-051X.2011.01806.x
PG 8
WC Dentistry, Oral Surgery & Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dentistry, Oral Surgery & Medicine
GA 861IP
UT WOS:000298012900004
PM 22092822
DA 2025-06-11
ER

PT J
AU Azfar, RS
   Gelfand, JM
AF Azfar, Rahat S.
   Gelfand, Joel M.
TI Psoriasis and metabolic disease: epidemiology and pathophysiology
SO CURRENT OPINION IN RHEUMATOLOGY
LA English
DT Review
DE epidemiology; inflammation; metabolic syndrome; myocardial infarction;
   psoriasis
ID GROWTH-FACTOR-II; CARDIOVASCULAR-DISEASE; RISK-FACTORS; OBESITY;
   ATHEROSCLEROSIS; SUSCEPTIBILITY; PROLIFERATION; HOMOCYSTEINE;
   ASSOCIATION; DYSFUNCTION
AB Purpose of review The scientific literature linking psoriasis to metabolic syndrome, and its components, as well as atherosclerosis and myocardial infarction has rapidly expanded. Increasingly, epidemiological studies are establishing the directionality of these associations and psoriasis' role as an independent risk factor in developing these outcomes.
   Recent findings Psoriasis is associated with metabolic syndrome, and its components, such as obesity, diabetes, and hypertension. Obesity has been shown to be an independent risk factor for the development of psoriasis, and is also associated with more severe psoriasis. Psoriasis is associated with diabetes, coronary artery disease, and an increased risk for myocardial infarction independent of traditional risk factors for these disorders. These phenotypically diverse conditions share similar pathologic changes such as chronic inflammation, angiogenesis, oxidative stress, and selected susceptibility genes and loci.
   Summary The broad literature linking psoriasis to metabolic disorders has led to changes in standard of care recommendations for patients with psoriasis. In particular, practitioners are encouraged to screen psoriasis patients, especially when disease is severe, for metabolic disorders and cardiovascular risk factors and institute appropriate prevention strategies. Additional studies investigating the role of psoriasis activity and severity as an independent risk factor for developing metabolic disorders, atherosclerosis, and myocardial infarction and the role of psoriasis treatment in altering the risk of developing these serious morbidities are urgently needed.
C1 [Azfar, Rahat S.; Gelfand, Joel M.] Univ Penn, Dept Dermatol, Philadelphia, PA 19104 USA.
   [Gelfand, Joel M.] Univ Penn, Ctr Clin Epidemiol & Biostat, Philadelphia, PA 19104 USA.
C3 University of Pennsylvania; University of Pennsylvania
RP Gelfand, JM (corresponding author), 3600 Spruce St,2 Maloney Bldg, Philadelphia, PA 19104 USA.
EM Joel.Gelfand@uphs.upenn.edu
OI Gelfand, Joel/0000-0003-3480-2661
FU NIAMS NIH HHS [K23 AR051125, F32 AR056799, K23-AR051125] Funding Source:
   Medline
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NR 52
TC 210
Z9 232
U1 0
U2 18
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1040-8711
EI 1531-6963
J9 CURR OPIN RHEUMATOL
JI Curr. Opin. Rheumatol.
PD JUL
PY 2008
VL 20
IS 4
BP 416
EP 422
DI 10.1097/BOR.0b013e3283031c99
PG 7
WC Rheumatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Rheumatology
GA 322ML
UT WOS:000257379200007
PM 18525354
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Hsu, CN
   Hou, CY
   Hsu, WH
   Tain, YL
AF Hsu, Chien-Ning
   Hou, Chih-Yao
   Hsu, Wei-Hsuan
   Tain, You-Lin
TI Early-Life Origins of Metabolic Syndrome: Mechanisms and Preventive
   Aspects
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE cardiovascular disease; obesity; hypertension; oxidative stress;
   metabolic syndrome; dyslipidemia; insulin resistance; diabetes; nutrient
   sensing; developmental origins of health and disease (DOHaD)
ID HIGH-FAT DIET; RENIN-ANGIOTENSIN SYSTEM; INDUCED PROGRAMMED
   HYPERTENSION; IN-UTERO EXPOSURE; LOW-PROTEIN DIET; INCREASES
   BLOOD-PRESSURE; REDUCES NEPHRON NUMBER; HIGH-FRUCTOSE DIET;
   LOW-BIRTH-WEIGHT; DEVELOPMENTAL ORIGINS
AB One of the leading global public-health burdens is metabolic syndrome (MetS), despite the many advances in pharmacotherapies. MetS, now known as "developmental origins of health and disease " (DOHaD), can have its origins in early life. Offspring MetS can be programmed by various adverse early-life conditions, such as nutrition imbalance, maternal conditions or diseases, maternal chemical exposure, and medication use. Conversely, early interventions have shown potential to revoke programming processes to prevent MetS of developmental origins, namely reprogramming. In this review, we summarize what is currently known about adverse environmental insults implicated in MetS of developmental origins, including the fundamental underlying mechanisms. We also describe animal models that have been developed to study the developmental programming of MetS. This review extends previous research reviews by addressing implementation of reprogramming strategies to prevent the programming of MetS. These mechanism-targeted strategies include antioxidants, melatonin, resveratrol, probiotics/prebiotics, and amino acids. Much work remains to be accomplished to determine the insults that could induce MetS, to identify the mechanisms behind MetS programming, and to develop potential reprogramming strategies for clinical translation.
C1 [Hsu, Chien-Ning] Kaohsiung Chang Gung Mem Hosp, Dept Pharm, Kaohsiung 833, Taiwan.
   [Hsu, Chien-Ning] Kaohsiung Med Univ, Sch Pharm, Kaohsiung 807, Taiwan.
   [Hou, Chih-Yao] Natl Kaohsiung Univ Sci & Technol, Dept Seafood Sci, Kaohsiung 811, Taiwan.
   [Hsu, Wei-Hsuan] Natl Chen Kung Univ, Coll Med, Dept Food Safety Hyg & Risk Management, Tainan 701, Taiwan.
   [Tain, You-Lin] Kaohsiung Chang Gung Mem Hosp, Dept Pediat, Kaohsiung 833, Taiwan.
   [Tain, You-Lin] Chang Gung Univ, Coll Med, Kaohsiung 833, Taiwan.
   [Tain, You-Lin] Kaohsiung Chang Gung Mem Hosp, Inst Translat Res Biomed, Kaohsiung 833, Taiwan.
C3 Chang Gung Memorial Hospital; Kaohsiung Medical University; National
   Kaohsiung University of Science & Technology; National Cheng Kung
   University; Chang Gung Memorial Hospital; Chang Gung University; Chang
   Gung Memorial Hospital
RP Tain, YL (corresponding author), Kaohsiung Chang Gung Mem Hosp, Dept Pediat, Kaohsiung 833, Taiwan.; Tain, YL (corresponding author), Chang Gung Univ, Coll Med, Kaohsiung 833, Taiwan.; Tain, YL (corresponding author), Kaohsiung Chang Gung Mem Hosp, Inst Translat Res Biomed, Kaohsiung 833, Taiwan.
EM cnhsu@cgmh.org.tw; chihyaohou@webmail.nkmu.edu.tw;
   whhsu@mail.ncku.edu.tw; tainyl@cgmh.org.tw
RI HOU, CHIH/S-4983-2018; Tain, You-Lin/H-2827-2019; Hsu,
   Chien-Ning/GLS-4014-2022
OI Hou, Chih-Yao/0000-0002-8007-6077; Hsu, Wei-Hsuan/0000-0002-6598-6435;
   Tain, You-Lin/0000-0002-7059-6407; Hsu, Chien-Ning/0000-0001-7470-528X
FU Ministry of Science and Technology, Taiwan [MOST 110-2314-B182A-029];
   Chang Gung Memorial Hospital, Kaohsiung, Taiwan [CFRPG8H0011,
   CMRPG8J0253, CORPG8J0121, CORPG8L0121, CORPG8L0261, CORPG8L0301]
FX This research was funded by the Ministry of Science and Technology,
   Taiwan, grant MOST 110-2314-B182A-029, and Chang Gung Memorial Hospital,
   Kaohsiung, Taiwan, grants CFRPG8H0011, CMRPG8J0253, CORPG8J0121,
   CORPG8L0121, CORPG8L0261, and CORPG8L0301.
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NR 199
TC 53
Z9 55
U1 2
U2 31
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD NOV
PY 2021
VL 22
IS 21
AR 11872
DI 10.3390/ijms222111872
PG 21
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA XE3JG
UT WOS:000723287600001
PM 34769303
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Jakovljevic, V
   Milic, P
   Bradic, J
   Jeremic, J
   Zivkovic, V
   Srejovic, I
   Turnic, TN
   Milosavljevic, I
   Jeremic, N
   Bolevich, S
   Borovic, ML
   Mitrovic, M
   Vucic, V
AF Jakovljevic, Vladimir
   Milic, Petar
   Bradic, Jovana
   Jeremic, Jovana
   Zivkovic, Vladimir
   Srejovic, Ivan
   Turnic, Tamara Nikolic
   Milosavljevic, Isidora
   Jeremic, Nevena
   Bolevich, Sergey
   Borovic, Milica Labudovic
   Mitrovic, Miroslav
   Vucic, Vesna
TI Standardized Aronia melanocarpa Extract as Novel Supplement
   against Metabolic Syndrome: A Rat Model
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE metabolic syndrome; Aronia melanocarpa; standardized extract; dietary
   strategies; supplementation
ID BLOOD-PRESSURE; ETHANOLIC EXTRACT; FAT; CHOKEBERRY; DIET;
   ECHOCARDIOGRAPHY; INHIBITION; REDUCTION; QUALITY
AB The aim of our study was to examine the effects of different dietary strategies, high-fat (HFd) or standard diet (Sd) alone or in combination with standardized oral supplementation (0.45 mL/kg/day) of Aronia melanocarpa extract (SAE) in rats with metabolic syndrome (MetS). SAE is an official product of pharmaceutical company Pharmanova (Belgrade, Serbia); however, the procedure for extraction was done by EU-Chem company (Belgrade, Serbia). Rats were divided randomly into six groups: control with Sd, control with Sd and SAE, MetS with HFd, MetS with HFd and SAE, MetS with Sd and MetS with Sd and SAE during 4 weeks. At the end of the 4-week protocol, cardiac function and liver morphology were assessed, while in the blood samples glucose, insulin, iron levels and systemic redox state were determined. Our results demonstrated that SAE had the ability to lower blood pressure and exert benefits on in vivo and ex vivo heart function. Moreover, SAE improved glucose tolerance, attenuated pathological liver alterations and oxidative stress present in MetS. Obtained beneficial effects of SAE were more prominent in combination with changing dietary habits. Promising potential of SAE supplementation alone or in combination with different dietary protocols in triggering cardioprotection should be further examined in future.
C1 [Jakovljevic, Vladimir; Zivkovic, Vladimir; Srejovic, Ivan] Univ Kragujevac, Fac Med Sci, Dept Physiol, Svetozara Markovica 69, Kragujevac 34000, Serbia.
   [Jakovljevic, Vladimir; Bolevich, Sergey] Univ IM Sechenov, Moscow State Med 1, Dept Human Pathol, Trubetskaya St 8, Moscow 119991, Russia.
   [Milic, Petar] High Med Sch Profess Studies Cuprija, Dept Pharm, Lole Ribara 1-2, Cuprija 35000, Serbia.
   [Bradic, Jovana; Jeremic, Jovana; Turnic, Tamara Nikolic; Milosavljevic, Isidora; Jeremic, Nevena] Univ Kragujevac, Dept Pharm, Fac Med Sci, Svetozara Markovica 69, Kragujevac 34000, Serbia.
   [Borovic, Milica Labudovic] Univ Belgrade, Inst Histol & Embryol Aleksandar Dj Kostic, Fac Med, Dr Subotic 8, Belgrade 11000, Serbia.
   [Mitrovic, Miroslav] Pharmanova, Gen Anrija 6, Belgrade 11010, Serbia.
   [Vucic, Vesna] Univ Belgrade, Inst Med Res, Ctr Res Excellence Nutr & Metab, Tadeusa Koscuska 1, Belgrade 11129, Serbia.
C3 University of Kragujevac; Sechenov First Moscow State Medical
   University; University of Kragujevac; University of Belgrade; University
   of Belgrade
RP Jakovljevic, V (corresponding author), Univ Kragujevac, Fac Med Sci, Dept Physiol, Svetozara Markovica 69, Kragujevac 34000, Serbia.; Jakovljevic, V (corresponding author), Univ IM Sechenov, Moscow State Med 1, Dept Human Pathol, Trubetskaya St 8, Moscow 119991, Russia.
EM drvladakgbg@yahoo.com; milic.milic@gmail.com; jovanabradickg@gmail.com;
   jovana.jeremic@medf.kg.ac.rs; vladimirziv@gmail.com;
   ivan_srejovic@hotmail.com; tamara.nikolic@medf.kg.ac.rs;
   isidora.stojic@medf.kg.ac.rs; nbarudzic@hotmail.com;
   bolevich2011@yandex.ru; milic.milic@gmail.com;
   miroslav.mitrovic@pharmanova.com; vesna.vucic.imr@gmail.com
RI Bolevich, Sergey/V-1798-2019; Nikolic Turnic, Tamara/AAZ-2847-2020;
   Jeremic, Nevena/U-9443-2019; Zivkovic, Vladimir/U-8941-2019; Srejovic,
   Ivan/L-2468-2019; Jeremic, Jovana/ABH-9087-2020; vucic,
   vesna/AFN-8591-2022; Bradic, Jovana/ABH-9126-2020; Stojic,
   Isidora/AAY-6092-2020; Jakovljevic, Vladimir/V-1583-2019
OI Novakovic, Jovana/0000-0002-8084-3264; Labudovic Borovic,
   Milica/0000-0003-1471-0014; Zivkovic, Vladimir/0000-0001-9354-9876;
   Bradic, Jovana/0000-0001-5388-6085; Srejovic, Ivan/0000-0002-3835-1856;
   Mitrovic, Miroslav/0000-0001-6872-9728; Bolevich,
   Sergey/0000-0002-1574-477X; Nikolic Turnic, Tamara/0000-0002-9105-1350;
   Vucic, Vesna/0000-0002-8563-594X; Stojic, Isidora/0000-0001-9141-4281
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NR 57
TC 26
Z9 28
U1 0
U2 15
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD JAN 1
PY 2019
VL 20
IS 1
AR 6
DI 10.3390/ijms20010006
PG 19
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA HM8RD
UT WOS:000459747700006
PM 30577476
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Yilmaz, H
   Sayar, N
   Yilmaz, M
   Gurkan, U
   Sesal, C
   Tosu, R
   Cakmak, N
   Erer, B
   Oz, D
   Ciloglu, F
   Bolca, O
AF Yilmaz, Hale
   Sayar, Nurten
   Yilmaz, Mehmet
   Gurkan, Ufuk
   Sesal, Cenk
   Tosu, Rodi
   Cakmak, Nazmiye
   Erer, Betul
   Oz, Dilaver
   Ciloglu, Figen
   Bolca, Osman
TI Serum paraoxonase 1 activity in women with metabolic syndrome
SO KARDIOLOGIA POLSKA
LA English
DT Article
DE paraoxonase activity; metabolic syndrome; coronary artery disease
ID CORONARY-ARTERY-DISEASE; LOW-DENSITY-LIPOPROTEIN; HYDROLYTIC ACTIVITY;
   DIABETES-MELLITUS; OXIDATIVE STRESS; PREVALENCE; POLYMORPHISM;
   ASSOCIATION; PHENOTYPE; IMPACT
AB Background: Metabolic syndrome (MetS) is a leading risk factor for coronary artery disease (CAD) in women. Reduced paraoxonase 1 (PON1) activity may play a role in the pathogenesis of atherosclerosis through increased susceptibility to lipid peroxidation in patients with MetS.
   Aim: To examine whether there is a relationship between serum PON1 activity and MetS in women.
   Method: The study group consisted of 54 women with MetS. The NCEP ATP III guidelines were used to define MetS. The control group consisted of 65 women without MetS and CAD. All patients from the MetS group underwent coronary angiography.
   Results: The PON1 activity and salt-stimulated PON1 activity were not significantly altered in women with MetS when compared to controls (p = 0.902, p = 0.877, respectively). There was no significant difference in PON1 activity (p = 0.159), and salt-stimulated PON1 activity (p = 0.139) between diabetics and non-diabetics. In the MetS group, patients with CAD (n = 16) had significantly reduced PON1 activity and salt-stimulated PON1 activity compared to MetS patients without CAD (p = 0.008 and p = 0.004, respectively).
   Conclusions: Serum PON1 activity is significantly reduced in women with CAD and MetS. MetS per se does not alter serum PON1 activities.
C1 [Yilmaz, Hale; Sayar, Nurten; Gurkan, Ufuk; Tosu, Rodi; Cakmak, Nazmiye; Erer, Betul; Oz, Dilaver; Bolca, Osman] Siyami Ersek Thorac & Cardiovasc Surg Ctr, Dept Cardiol, Istanbul, Turkey.
   [Yilmaz, Mehmet] Siyami Ersek Thorac & Cardiovasc Surg Ctr, Dept Cardiovasc Surg, Istanbul, Turkey.
   [Sesal, Cenk] Univ Marmara, Fac Sci & Art, Dept Biol, Istanbul, Turkey.
   [Ciloglu, Figen] Genlab Med Diagnost & Res Lab, Istanbul, Turkey.
C3 Dr. Siyami Ersek Cardiac & Vascular Surgery Training & Research
   Hospital; Dr. Siyami Ersek Cardiac & Vascular Surgery Training &
   Research Hospital; Marmara University; Genlab Group
RP Yilmaz, H (corresponding author), Barbaros Mah Zambak Sokak,Kentplus Sitesi D2 Blok, Istanbul, Turkey.
EM haleyilmaz@tnn.net
RI gürkan, ufuk/GPP-3376-2022; Yilmaz, Hale/AAE-1109-2021; bolca,
   osman/JYP-8138-2024; ozbilgin, nazmiye/MIP-3381-2025; Yilmaz,
   Mehmet/X-6273-2019
OI Yilmaz, Mehmet/0000-0002-6243-6876; YILMAZ, HALE/0000-0002-6365-2423;
   Sesal, Cenk/0000-0002-0737-0122
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NR 37
TC 6
Z9 8
U1 0
U2 6
PU POLSKIE TOWARZYSTOWO KARDIOLOGICZNE
PI WARSZAWA
PA UL STAWKI 3 A LOK 1-2, WARSZAWA, POLAND
SN 0022-9032
EI 1897-4279
J9 KARDIOL POL
JI Kardiol. Pol.
PD NOV
PY 2010
VL 68
IS 11
BP 1219
EP 1225
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 721IN
UT WOS:000287346900003
PM 21108196
DA 2025-06-11
ER

PT J
AU Soegaard, EGI
   Kan, Z
   Aass, HCD
   Koirala, R
   Hauff, E
   Thapa, SB
AF Soegaard, Erik Ganesh Iyer
   Kan, Zhanna
   Aass, Hans Christian Dalsbotten
   Koirala, Rishav
   Hauff, Edvard
   Thapa, Suraj Bahadur
TI Abnormal Cytokines in Trauma Patients Explained by Obesity,
   Musculoskeletal Disease, Smoking, and Lung Disease
SO NEUROPSYCHOBIOLOGY
LA English
DT Article
DE Cytokines; Trauma; PTSD; Metabolic syndrome; Body mass index; Low-grade
   inflammation
ID POSTTRAUMATIC-STRESS-DISORDER; COMBAT-RELATED PTSD; METABOLIC SYNDROME;
   INFLAMMATORY MARKERS; CARDIOVASCULAR-DISEASE; ADIPOSE-TISSUE;
   ASSOCIATION; RISK; PREVALENCE; DEPRESSION
AB Introduction: Low-grade inflammation observed through abnormal plasma cytokine levels has been associated with post-traumatic stress disorder (PTSD). It is not clear whether PTSD independently causes the inflammation or if it is mainly through co-occurring somatic factors such as smoking and obesity. We wanted to explore the effects of biopsychosocial factors on cytokine levels in a clinical setting. Methods: The sample consisted of 51 patients with PTSD, 58 trauma patients without PTSD, and 40 matched controls. We selected cytokines and relevant risk factors for systemic inflammation through pairwise correlations. Then, we used linear regression to analyze the individual and combined effects of these on the (Log(10)) cytokines, particularly estimating the effect of PTSD adjusted for other factors. Results: Higher age, female gender, cigarette smoking, presence of lung and musculoskeletal disease, use of antipsychotic medication, and higher BMI were correlated with higher levels of interleukins IL-1RA, IL-2RA, and IL-6. In the adjusted regression analysis, higher BMI was associated with increased IL-1RA (B = 0.06, p < 0.01), IL-2RA (B = 0.01, p < 0.01), and IL-6 (B = 0.01, p = 0.03). Presence of musculoskeletal disease was associated with increased IL-1RA (B = 0.72, p < 0.01) and IL-6 (B = 0.16, p = 0.01), and decreased IL-2RA (B = -0.09, p < 0.01). Cigarette smoking (B = 0.16, p = 0.01) and presence of lung disease (B = 0.14, p = 0.02) were associated with increased IL-6. PTSD diagnosis was associated with decreased IL-2RA (B = -0.06, p = 0.04). Discussion/Conclusion: Altered cytokine levels in distressed trauma-affected individuals are probably mostly through co-occurring risk factors and not PTSD diagnosis. Increased BMI and musculoskeletal (pain) disease may be particularly strong risk factors and should be addressed.
C1 [Soegaard, Erik Ganesh Iyer; Kan, Zhanna; Hauff, Edvard; Thapa, Suraj Bahadur] Oslo Univ Hosp, Div Mental Hlth & Addict, Oslo, Norway.
   [Soegaard, Erik Ganesh Iyer; Koirala, Rishav; Hauff, Edvard; Thapa, Suraj Bahadur] Univ Oslo, Inst Clin Med, Div Mental Hlth & Addict, Oslo, Norway.
   [Aass, Hans Christian Dalsbotten] Oslo Univ Hosp, Div Med Biochem, Oslo, Norway.
   [Koirala, Rishav] Brain & Neurosci Ctr, Kathmandu, Nepal.
C3 University of Oslo; University of Oslo; University of Oslo
RP Soegaard, EGI (corresponding author), Oslo Univ Hosp, Div Mental Hlth & Addict, Oslo, Norway.; Soegaard, EGI (corresponding author), Univ Oslo, Inst Clin Med, Div Mental Hlth & Addict, Oslo, Norway.
EM erikganesh@hotmail.com
RI Soegaard, Erik/IQT-7355-2023
OI Koirala, Rishav/0000-0002-9721-2952; Soegaard, Erik Ganesh
   Iyer/0000-0003-2380-4995
FU Regional Health Authority of South-Eastern Norway; Oslo University
   Hospital;  [08/00020-2008024]
FX The project received a research grant from the Regional Health Authority
   of South-Eastern Norway in 2008 [No. 08/00020-2008024] and a grant from
   Oslo University Hospital in 2016. The funding did not affect the choice
   of data, analysis, interpretation, or manuscript writing and submission.
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NR 100
TC 0
Z9 0
U1 0
U2 2
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0302-282X
EI 1423-0224
J9 NEUROPSYCHOBIOLOGY
JI Neuropsychobiology
PD DEC
PY 2022
VL 81
IS 6
BP 516
EP 530
DI 10.1159/000526806
EA OCT 2022
PG 15
WC Neurosciences; Psychiatry; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Psychiatry; Psychology
GA 6Y7JK
UT WOS:000879415600001
PM 36302340
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Wu, JP
   Jia, WH
   Min, DY
   Yang, GL
AF Wu, Junpeng
   Jia, Wenhan
   Min, Dongyu
   Yang, Guanlin
TI Cinnamon for Metabolic Diseases and Their Cardiovascular and Hepatic
   Complications: A Mechanistic Review
SO AMERICAN JOURNAL OF CHINESE MEDICINE
LA English
DT Article
DE Cinnamon; Metabolic Syndrome; Complications; Cinnamaldehyde; Fatty
   Liver; Cardiovascular; Blood Pressure
ID DIET-INDUCED OBESITY; HIGH-FAT DIET; BLOOD-PRESSURE; ADIPOSE-TISSUE;
   DIABETIC MICE; CINNAMALDEHYDE; METAANALYSIS; SUPPLEMENTATION; EXTRACT;
   KINASE
AB Cinnamon is one of the world's oldest and most popular spices, and is derived from the inner bark of several tree species from the genus Cinnamomum. During the last two decades, cinnamon has demonstrated beneficial metabolic effects not only in animal experiments but also in clinical trials. Even recent meta-analyses have shown the protective effects of cinnamon on different components of metabolic syndrome and their complications. In the last 5 years, several experimental studies have unraveled the intricate molecular mechanisms underlying the antihypertensive, antihyperglycemic, lipid-lowering, weight-lowering, and cardioprotective properties of cinnamon. This review paper will discuss how cinnamon and its active components, particularly cinnamaldehyde, suppress inflammation and oxidative stress, modulate mitochondrial dysfunction, and regulate glucose uptake, insulin resistance, lipogenesis, beta-oxidation, Ca2+ signaling, and other cellar events at the molecular level. Specifically, we will delve into the molecular mechanisms involved in the metabolic effects of cinnamon to provide a deeper insight into how cinnamon can bring such beneficial effects. This review hopes to encourage the use of cinnamon in clinical settings, guide the combination of cinnamon with other drugs used to treat different components of metabolic syndrome based on their mechanism of action, and support the concept of complementary medicine for metabolic diseases.
C1 [Wu, Junpeng; Yang, Guanlin] Liaoning Univ Tradit Chinese Med, Clin Coll 1, 79 Chongshan East Rd, Shenyang 110000, Liaoning, Peoples R China.
   [Wu, Junpeng; Yang, Guanlin] Liaoning Univ Tradit Chinese Med, Key Lab, Minist Educ Tradit Chinese Med Viscera State Theor, 79 Chongshan East Rd, Shenyang 110000, Liaoning, Peoples R China.
   [Jia, Wenhan] Liaoning Univ Tradit Chinese Med, P, R China, Shenyang 110000, Liaoning, Peoples R China.
   [Min, Dongyu] Liaoning Univ Tradit Chinese Med, Affiliated Hosp, 33 Beiling St, Shenyang 110000, Liaoning, Peoples R China.
C3 Liaoning University of Traditional Chinese Medicine; Liaoning University
   of Traditional Chinese Medicine; Liaoning University of Traditional
   Chinese Medicine; Liaoning University of Traditional Chinese Medicine
RP Yang, GL (corresponding author), Liaoning Univ Tradit Chinese Med, Clin Coll 1, 79 Chongshan East Rd, Shenyang 110000, Liaoning, Peoples R China.; Yang, GL (corresponding author), Liaoning Univ Tradit Chinese Med, Key Lab, Minist Educ Tradit Chinese Med Viscera State Theor, 79 Chongshan East Rd, Shenyang 110000, Liaoning, Peoples R China.; Min, DY (corresponding author), Liaoning Univ Tradit Chinese Med, Affiliated Hosp, 33 Beiling St, Shenyang 110000, Liaoning, Peoples R China.
EM mindongyu@163.com; guanli19621010@163.com
RI wu, junpeng/MBG-9584-2025
OI wu, junpeng/0009-0004-9242-6283; dongyu, min/0000-0001-6646-9555; JIA,
   wenhan/0009-0008-7412-9188
FU National Natural Science Fund [82374423]
FX This study was financially supported by the National Natural Science
   Fund (82374423).
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NR 92
TC 0
Z9 0
U1 8
U2 8
PU WORLD SCIENTIFIC PUBL CO PTE LTD
PI SINGAPORE
PA 5 TOH TUCK LINK, SINGAPORE 596224, SINGAPORE
SN 0192-415X
EI 1793-6853
J9 AM J CHINESE MED
JI Am. J. Chin. Med.
PY 2024
VL 52
IS 08
BP 2403
EP 2421
DI 10.1142/S0192415X24500915
EA DEC 2024
PG 19
WC Integrative & Complementary Medicine; Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine; General & Internal Medicine
GA R2F8O
UT WOS:001380219300001
PM 39702975
DA 2025-06-11
ER

PT J
AU Nouri, Z
   Hajialyani, M
   Izadi, Z
   Bahramsoltani, R
   Farzaei, MH
   Abdollahi, M
AF Nouri, Zeinab
   Hajialyani, Marziyeh
   Izadi, Zhila
   Bahramsoltani, Roodabeh
   Farzaei, Mohammad Hosein
   Abdollahi, Mohammad
TI Nanophytomedicines for the Prevention of Metabolic Syndrome: A
   Pharmacological and Biopharmaceutical Review
SO FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
LA English
DT Review
DE medicinal plants; nanoparticles; diabetes; metabolic syndrome;
   nanophytomedicines; phytotherapy
ID SOLID LIPID NANOPARTICLES; SYNTHESIZED GOLD NANOPARTICLES; CONJUGATED
   LINOLENIC ACID; TYPE-2 DIABETES-MELLITUS; NF-KAPPA-B; SILVER
   NANOPARTICLES; IN-VITRO; INSULIN-RESISTANCE; ZNO NANOPARTICLES;
   OXIDATIVE STRESS
AB Metabolic syndrome includes a series of metabolic abnormalities that leads to diabetes mellitus and cardiovascular diseases. Plant extracts, due to their unique advantages like anti-inflammatory, antioxidant, and insulin sensitizing properties, are interesting therapeutic options to manage MetS; however, the poor solubility and low bioavailability of lipophilic bioactive components in the herbal extracts are two critical challenges. Nano-scale delivery systems are suitable to improve delivery of herbal extracts. This review, for the first time, focuses on nanoformulations of herbal extracts in MetS and related complications. Included studies showed that several forms of nano drug delivery systems such as nanoemulsions, solid lipid nanoparticles, nanobiocomposites, and green-synthesized silver, gold, and zinc oxide nanoparticles have been developed using herbal extracts. It was shown that the method of preparation and related parameters such as temperature and type of polymer are important factors affecting physicochemical stability and therapeutic activity of the final product. Many of these formulations could successfully decrease the lipid profile, inflammation, oxidative damage, and insulin resistance in in vitro and in vivo models of MetS-related complications. Further studies are still needed to confirm the safety and efficacy of these novel herbal formulations for clinical application.
C1 [Nouri, Zeinab] Kermanshah Univ Med Sci, Students Res Comm, Fac Pharm, Kermanshah, Iran.
   [Hajialyani, Marziyeh; Izadi, Zhila; Farzaei, Mohammad Hosein] Kermanshah Univ Med Sci, Hlth Inst, Pharmaceut Sci Res Ctr, Kermanshah, Iran.
   [Bahramsoltani, Roodabeh] Univ Tehran Med Sci, Sch Persian Med, Dept Tradit Pharm, Tehran, Iran.
   [Bahramsoltani, Roodabeh] Univ Sci Educ & Res Network, PhytoPharmacol Interest Grp, Tehran, Iran.
   [Farzaei, Mohammad Hosein] Kermanshah Univ Med Sci, Med Biol Res Ctr, Kermanshah, Iran.
   [Abdollahi, Mohammad] Univ Tehran Med Sci, Inst Pharmaceut Sci, Toxicol & Dis Grp, Pharmaceut Sci Res Ctr, Tehran, Iran.
   [Abdollahi, Mohammad] Univ Tehran Med Sci, Sch Pharm, Dept Pharmacol & Toxicol, Tehran, Iran.
C3 Kermanshah University of Medical Sciences; Kermanshah University of
   Medical Sciences; Tehran University of Medical Sciences; Kermanshah
   University of Medical Sciences; Tehran University of Medical Sciences;
   Tehran University of Medical Sciences
RP Farzaei, MH (corresponding author), Kermanshah Univ Med Sci, Hlth Inst, Pharmaceut Sci Res Ctr, Kermanshah, Iran.; Farzaei, MH (corresponding author), Kermanshah Univ Med Sci, Med Biol Res Ctr, Kermanshah, Iran.; Abdollahi, M (corresponding author), Univ Tehran Med Sci, Inst Pharmaceut Sci, Toxicol & Dis Grp, Pharmaceut Sci Res Ctr, Tehran, Iran.; Abdollahi, M (corresponding author), Univ Tehran Med Sci, Sch Pharm, Dept Pharmacol & Toxicol, Tehran, Iran.
EM mh.farzaei@gmail.com; Mohammad@TUMS.Ac.Ir
RI Izadi, Zhila/AGU-5007-2022; Farzaei, Mohammad/M-5779-2017;
   Bahramsoltani, Roodabeh/A-1001-2018; /B-9232-2008
OI Bahramsoltani, Roodabeh/0000-0001-6942-0546; /0000-0003-0123-1209
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NR 181
TC 31
Z9 32
U1 2
U2 18
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-4185
J9 FRONT BIOENG BIOTECH
JI Front. Bioeng. Biotechnol.
PD MAY 14
PY 2020
VL 8
AR 425
DI 10.3389/fbioe.2020.00425
PG 18
WC Biotechnology & Applied Microbiology; Engineering, Biomedical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Engineering
GA LV5VR
UT WOS:000538503000001
PM 32478050
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Dupas, J
   Feray, A
   Goanvec, C
   Guernec, A
   Samson, N
   Bougaran, P
   Guerrero, F
   Mansourati, J
AF Dupas, Julie
   Feray, Annie
   Goanvec, Christelle
   Guernec, Anthony
   Samson, Nolwenn
   Bougaran, Pauline
   Guerrero, Francois
   Mansourati, Jacques
TI Metabolic Syndrome and Hypertension Resulting from Fructose Enriched
   Diet in Wistar Rats
SO BIOMED RESEARCH INTERNATIONAL
LA English
DT Article
ID TYPE-2 DIABETES-MELLITUS; FATTY LIVER-DISEASE; INSULIN-RESISTANCE;
   GLUCOSE-TOLERANCE; OXIDATIVE STRESS; HOMA-IR; PATHOPHYSIOLOGY;
   HOMEOSTASIS; PREVALENCE; PARAMETERS
AB Increased sugar consumption, especially fructose, is strongly related to the development of type 2 diabetes (T2D) and metabolic syndrome. The aim of this study was to evaluate long term effects of fructose supplementation on Wistar rats. Three-week-oldmale rats were randomly divided into 2 groups: control (C;n = 14) and fructose fed (FF;n = 18), with a fructose enriched drink (20-25% w/v fructose in water) for 21 weeks. Systolic blood pressure, fasting glycemia, and bodyweight were regularly measured. Glucose tolerance was evaluated three times using an oral glucose tolerance test. Insulin levels were measured concomitantly and insulin resistance markers were evaluated (HOMA 2-IR, Insulin Sensitivity Index for glycemia (ISI-gly)). Lipids profile was evaluated on plasma. This fructose supplementation resulted in the early induction of hypertension without renal failure (stable theoretical creatinine clearance) and in the progressive development of fasting hyperglycemia and insulin resistance (higher HOMA 2-IR, lower ISI-gly) without modification of glucose tolerance. FF rats presented dyslipidemia (higher plasma triglycerides) and early sign of liver malfunction (higher liver weight). Although abdominal fat weight was increased in FF rats, no significant overweight was found. In Wistar rats, 21 weeks of fructose supplementation induced a metabolic syndrome (hypertension, insulin resistance, and dyslipidemia) but not T2D.
C1 [Dupas, Julie; Feray, Annie; Goanvec, Christelle; Guernec, Anthony; Bougaran, Pauline; Guerrero, Francois; Mansourati, Jacques] Univ Bretagne Occidentale, Inst Brestois Sant Agro Mat, EA 4324 Optimisat Regulat Physiol, 6 Ave Victor Le Gorgeu, F-29238 Brest 3, France.
   [Feray, Annie; Guernec, Anthony; Guerrero, Francois] UFR Sci Sport & Educ, 20 Ave Victor Le Gorgeu, F-29238 Brest 3, France.
   [Goanvec, Christelle] UFR Sci & Tech, 6 Ave Victor Le Gorgeu, F-29238 Brest 3, France.
   [Samson, Nolwenn] Univ Laval, Inst Univ Cardiol & Pneumol Quebec, 2725 Chemin Ste Foy, Quebec City, PQ G1V 4G5, Canada.
   [Mansourati, Jacques] CHU Brest, Dept Cardiol, Blvd Tanguy Prigent, F-29200 Brest, France.
C3 Universite de Bretagne Occidentale; Laval University; Laval University
   Hospital; CHU Brest
RP Goanvec, C (corresponding author), Univ Bretagne Occidentale, Inst Brestois Sant Agro Mat, EA 4324 Optimisat Regulat Physiol, 6 Ave Victor Le Gorgeu, F-29238 Brest 3, France.; Goanvec, C (corresponding author), UFR Sci & Tech, 6 Ave Victor Le Gorgeu, F-29238 Brest 3, France.
EM christelle.goanvec@univ-brest.fr
RI Mansourati, Jacques/HLQ-5147-2023
OI Bougaran, Pauline/0000-0002-4064-2388; Guerrero,
   Francois/0000-0002-0283-3503; goanvec, christelle/0000-0002-1764-6778
FU Nathalie Guegueniat (Optimisation des Regulations Physiologiques,
   Universite de Bretagne Occidentale, Brest, France) [EA 4324]; Federation
   Francaise de Cardiologie
FX Authors wish to thank Nathalie Guegueniat (EA 4324-Optimisation des
   Regulations Physiologiques, Universite de Bretagne Occidentale, Brest,
   France) for her help in this project. This study was partially funded by
   the Federation Francaise de Cardiologie.
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NR 48
TC 52
Z9 57
U1 0
U2 6
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2314-6133
EI 2314-6141
J9 BIOMED RES INT
JI Biomed Res. Int.
PY 2017
VL 2017
AR 2494067
DI 10.1155/2017/2494067
PG 10
WC Biotechnology & Applied Microbiology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Research & Experimental Medicine
GA ES9UF
UT WOS:000399906200001
PM 28497040
OA Green Published, hybrid, Green Submitted
DA 2025-06-11
ER

PT J
AU Pervanidou, P
   Chrousos, GP
AF Pervanidou, P.
   Chrousos, G. P.
TI Post-traumatic stress disorder in children and adolescents: From sigmund
   Freud's "Trauma" to psychopathology and the (Dys)metabolic syndrome
SO HORMONE AND METABOLIC RESEARCH
LA English
DT Article; Proceedings Paper
CT Symposium on Cortisol Secretion Abnormalities
CY JUN, 2006
CL Bethesda, MD
SP NICHD
DE child development; salivary cortisol; catecholamines; brain; behavior
ID URINARY CATECHOLAMINE EXCRETION; CORTISOL-LEVELS; PTSD SYMPTOMS; PLASMA
   NOREPINEPHRINE; HOLOCAUST SURVIVORS; HIPPOCAMPAL VOLUME; SALIVARY
   CORTISOL; VIETNAM VETERANS; BASAL CORTISOL; SEXUAL-ABUSE
AB Post-traumatic Stress Disorder (PTSD) is an anxiety syndrome that develops after exposure to traumatic life events. Symptoms include reexperience of the initial trauma, avoidance of stimuli associated with the trauma and symptoms of excessive arousal. Neuroenclocrine studies in adults with PTSD have demonstrated that basal cerebrospinal fluid (CSF) CRH levels are elevated and urinary cortisol levels are variable - low in the majority of cases - whereas other studies demonstrate no differences in urinary and plasma cortisol concentrations. Urinary catecholamine excretion is higher in PTSD patients than those of control subjects and other psychiatric disorders.
   Children may differ from adults in their psychologic and physiologic responses to severe stressors. Also, exposure to stress during critical periods of development may have irreversible effects on behavioral maturation and may affect specific vulnerable brain areas, altering CNS development. Similar to findings in adult studies, PTSD in children is characterized by increased sympathetic nervous system (SNS) activity, as indicated by elevated norepinephrine levels in the periphery. High cortisol levels in urine or saliva have been reported in most studies of childhood PTSD, while prospective longitudinal studies concerning the natural history of neuroendocrine changes in pediatric PTSD after an acute stressor are limited. The identification of neurobiologic changes in response to early adverse experiences is of major importance for the prognosis, prevention, management, and treatment of children and adolescents at risk for or suffering from PTSD.
C1 Univ Athens, Sch Med, Aghia Sophia Childrens Hosp, Dept Pediat 1, Athens, Greece.
C3 Athens Medical School; National & Kapodistrian University of Athens; The
   Aghia Sophia Children's Hospital
RP Pervanidou, P (corresponding author), Univ Athens, Sch Med, Aghia Sophia Childrens Hosp, Dept Pediat 1, Thivon & Levadias St, Athens, Greece.
EM ppervanid@med.uoa.gr
RI Pervanidou, Panagiota/ABI-6356-2020
OI Pervanidou, Panagiota/0000-0002-6593-6489
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NR 63
TC 48
Z9 52
U1 0
U2 22
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0018-5043
EI 1439-4286
J9 HORM METAB RES
JI Horm. Metab. Res.
PD JUN
PY 2007
VL 39
IS 6
BP 413
EP 419
DI 10.1055/s-2007-981461
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI); Conference Proceedings Citation Index - Science (CPCI-S)
SC Endocrinology & Metabolism
GA 185SP
UT WOS:000247731000003
PM 17578757
DA 2025-06-11
ER

PT J
AU Yeom, S
   Lee, DH
   Song, J
AF Yeom, Sujung
   Lee, Dong Hoon
   Song, Juhyun
TI Therapeutic Potential of Anti-Diabetes Drugs and Anti-Dyslipidemia Drugs
   to Mitigate Head and Neck Cancer Risk in Metabolic Syndrome
SO CNS NEUROSCIENCE & THERAPEUTICS
LA English
DT Review
DE anti-diabetic drugs; anti-dyslipidemic drugs; head and neck cancer
   (HNC); metabolic syndrome (Mets)
ID BODY-MASS INDEX; ENDOMETRIAL CANCER; PPAR-GAMMA; SIGNALING PATHWAY;
   COLORECTAL-CANCER; OXIDATIVE STRESS; BREAST-CANCER; CELL-PROLIFERATION;
   INSULIN-RESISTANCE; STEM-CELLS
AB BackgroundHead and neck cancer (HNC) encompasses a heterogeneous group of malignancies originating in the oral cavity, pharynx, nasopharynx, larynx, paranasal sinuses, and salivary glands. Accumulating evidence indicates that metabolic syndrome (MetS) characterized by a constellation of conditions including central adiposity, hyperglycemia, dyslipidemia, hypertension, and insulin resistance, may significantly influence cancer pathogenesis and progression.ResultsMetS has been epidemiologically linked to elevated risk for multiple malignancies through various metabolic mechanisms involving chronic systemic inflammation, insulin resistance, and dysregulated lipid metabolism. Especially in HNC, recent studies demonstrated that MetS and metabolic imbalance conditions may contribute to carcinogenesis, disease progression, and clinical outcomes, but the exact mechanisms behind the association between excess fat accumulation and HNC risk remain unclear. Considering previous studies, pharmacological agents targeting metabolic pathways, including biguanides (metformin), thiazolidinediones, sodium-glucose cotransporter-2 (SGLT-2) inhibitors, and HMG-CoA reductase inhibitors (statins) are being investigated for potential repurposing in cancer prevention and adjuvant therapy.ConclusionsHere, we summarize the latest evidence on the relationship between MetS and HNC, highlighting the therapeutic potential of anti-diabetes drugs and anti-dyslipidemia drugs in ameliorating various pathological problems in HNC patients with MetS.
C1 [Yeom, Sujung; Lee, Dong Hoon] Chonnam Natl Univ, Hwasun Hosp, Med Sch, Dept Otolaryngol Head & Neck Surg, Hwasun, South Korea.
   [Song, Juhyun] Chonnam Natl Univ, Med Sch, Dept Anat, Hwasun, South Korea.
C3 Chonnam National University; Chonnam National University
RP Lee, DH (corresponding author), Chonnam Natl Univ, Hwasun Hosp, Med Sch, Dept Otolaryngol Head & Neck Surg, Hwasun, South Korea.; Song, J (corresponding author), Chonnam Natl Univ, Med Sch, Dept Anat, Hwasun, South Korea.
EM leen3l@chonnam.ac.kr; juhyunsong@chonnam.ac.kr
FU Chonnam National University Hwasun Hospital Institute for Biomedical
   Science [RS-2022-NR069292]; National Research Foundation of Korea
   [HCRI24023]; Chonnam National University Hwasun Hospital Institute for
   Biomedical Science, Korea
FX This study was supported by grant RS-2022-NR069292 (Juhyun Song) from
   the National Research Foundation of Korea. HCRI24023 from the Chonnam
   National University Hwasun Hospital Institute for Biomedical Science,
   Korea (Juhyun Song and Dong Hoon Lee). The authors thank Biorender for
   making the figures.
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NR 180
TC 0
Z9 0
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1755-5930
EI 1755-5949
J9 CNS NEUROSCI THER
JI CNS Neurosci. Ther.
PD MAY
PY 2025
VL 31
IS 5
AR e70446
DI 10.1111/cns.70446
PG 24
WC Neurosciences; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pharmacology & Pharmacy
GA 2TM6F
UT WOS:001490937200001
PM 40387523
DA 2025-06-11
ER

PT J
AU DuBose, KD
   McKune, AJ
AF DuBose, Katrina D.
   McKune, Andrew J.
TI The Relationship Between Objectively Measured Physical Activity,
   Salivary Cortisol, and the Metabolic Syndrome Score in Girls
SO PEDIATRIC EXERCISE SCIENCE
LA English
DT Article
DE physical activity; salivary cortisol; metabolic syndrome; children
ID BODY-MASS INDEX; EPOCH LENGTH; SERUM CORTISOL; RISK-FACTORS; CHILDREN;
   EXERCISE; YOUTH; ADOLESCENTS; OBESITY; STRESS
AB The relationship between physical activity levels, salivary cortisol, and the metabolic syndrome (MetSyn) score was examined. Twenty-three girls (8.4 +/- 0.9 years) had a fasting blood draw, waist circumference and blood pressure measured, and wore an ActiGraph accelerometer for 5 days. Saliva samples were collected to measure cortisol levels. Previously established cut points estimated the minutes spent in moderate, vigorous, and moderate-to-vigorous physical activity. A continuous MetSyn score was created from blood pressure, waist circumference, high-density-lipoprotein (HDL), triglyceride, and glucose values. Correlation analyses examined associations between physical activity, cortisol, the MetSyn score, and its related components. Regression analysis examined the relationship between cortisol, the MetSyn score, and its related components adjusting for physical activity, percent body fat, and sexual maturity. Vigorous physical activity was positively related with 30 min post waking cortisol values. The MetSyn score was not related with cortisol values after controlling for confounders. In contrast, HDL was negatively related with 30 min post waking cortisol. Triglyceride was positively related with 30 min post waking cortisol and area under the curve. The MetSyn score and many of its components were not related to cortisol salivary levels even after adjusting for physical activity, body fat percentage, and sexual maturity.
C1 [DuBose, Katrina D.] E Carolina Univ, Dept Kinesiol, Greenville, NC 27858 USA.
   [McKune, Andrew J.] Univ KwaZulu Natal, Discipline Biokinet Exercise & Leisure Sci, Durban, South Africa.
C3 University of North Carolina; East Carolina University; University of
   Kwazulu Natal
RP DuBose, KD (corresponding author), E Carolina Univ, Dept Kinesiol, Greenville, NC 27858 USA.
EM dubosek@ecu.edu
RI McKune, Andrew/AAM-3086-2020
OI McKune, Andrew/0000-0002-5479-1544
FU Department of Kinesiology, East Carolina University
FX This work was supported by the Department of Kinesiology, East Carolina
   University.
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NR 51
TC 11
Z9 11
U1 1
U2 22
PU HUMAN KINETICS PUBL INC
PI CHAMPAIGN
PA 1607 N MARKET ST, PO BOX 5076, CHAMPAIGN, IL 61820-2200 USA
SN 0899-8493
EI 1543-2920
J9 PEDIATR EXERC SCI
JI Pediatr. Exerc. Sci.
PD AUG
PY 2014
VL 26
IS 3
BP 221
EP 230
DI 10.1123/pes.2013-0109
PG 10
WC Pediatrics; Physiology; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics; Physiology; Sport Sciences
GA AN3UH
UT WOS:000340513700001
PM 24722755
DA 2025-06-11
ER

PT J
AU Conroy, SM
   Butler, LM
   Harvey, D
   Gold, EB
   Sternfeld, B
   Greendale, GA
   Habel, LA
AF Conroy, Shannon M.
   Butler, Lesley M.
   Harvey, Danielle
   Gold, Ellen B.
   Sternfeld, Barbara
   Greendale, Gail A.
   Habel, Laurel A.
TI Metabolic syndrome and mammographic density: the Study of Women's Health
   Across the Nation
SO INTERNATIONAL JOURNAL OF CANCER
LA English
DT Article
DE adiposity; body mass index; breast cancer risk factor; mammographic
   density; metabolic syndrome
ID HUMAN BREAST-CANCER; GROWTH-FACTOR; INSULIN-RESISTANCE; SIGNALING
   PATHWAYS; OXIDATIVE STRESS; HDL-CHOLESTEROL; RISK; ASSOCIATION;
   POPULATION; GLUCOSE
AB The metabolic syndrome (MetS) is associated with an increase in breast cancer risk. In our study, we evaluated whether the MetS was associated with an increase in percent mammographic density (MD), a breast cancer risk factor. We used linear regression and mixed models to examine the cross-sectional and longitudinal associations of the MetS and components of the MetS to percent MD in 790 premenopausal and early perimenopausal women enrolled in the Study of Women's Health Across the Nation (SWAN). In cross-sectional analyses adjusted for body mass index (BMI), modest inverse associations were observed between percent MD and the MetS [beta = -2.5, standard error (SE) = 1.9, p = 0.19], abdominal adiposity (beta = -4.8, SE = 1.9, p = 0.01) and raised glucose (beta = -3.7, SE = 2.4, p = 0.12). In longitudinal models adjusted for covariates including age and BMI, abdominal adiposity (beta = 0.34, SE = 0.17, p = 0.05) was significantly positively associated with slower annual decline in percent MD with time. In conclusion, our results do not support the hypothesis that the MetS increases breast cancer risk via a mechanism reflected by an increase in percent MD.
C1 [Conroy, Shannon M.] Univ Hawaii, Ctr Canc, Canc Epidemiol Program, Honolulu, HI 96813 USA.
   [Conroy, Shannon M.; Harvey, Danielle; Gold, Ellen B.] Univ Calif Davis, Div Epidemiol, Dept Publ Hlth Sci, Davis, CA 95616 USA.
   [Butler, Lesley M.] Colorado State Univ, Dept Environm & Radiol Hlth Sci, Ft Collins, CO 80523 USA.
   [Greendale, Gail A.] Univ Calif Los Angeles, David Geffen Sch Med, Div Geriatr, Los Angeles, CA 90095 USA.
   [Sternfeld, Barbara; Habel, Laurel A.] Kaiser Permanente Med Care Program, Div Res, Oakland, CA 94611 USA.
C3 Cancer Research Center of Hawaii; University of Hawaii System;
   University of California System; University of California Davis;
   Colorado State University System; Colorado State University Fort
   Collins; University of California System; University of California Los
   Angeles; University of California Los Angeles Medical Center; David
   Geffen School of Medicine at UCLA; Kaiser Permanente
RP Conroy, SM (corresponding author), Univ Hawaii, Ctr Canc, Canc Epidemiol Program, 1236 Lauhala St,Suite 407, Honolulu, HI 96813 USA.
EM sconroy@crch.hawaii.edu
RI Harvey, Danielle/A-5496-2017
OI Conroy, Shannon/0000-0002-6120-8169; Habel, Laurel/0000-0002-7230-587X
FU National Institutes of Health (NIH); DHHS; National Institute on Aging
   (NIA); National Institute of Nursing Research (NINR); NIH Office of
   Research on Women's Health (ORWH) [NR004061, AG012505, AG012535,
   AG012531, AG012539, AG012546, AG012553, AG012554, AG012495]; National
   Cancer Institute [R01CA89552, R25CA90956]
FX Grant sponsors: National Institutes of Health (NIH), DHHS, National
   Institute on Aging (NIA), National Institute of Nursing Research (NINR),
   NIH Office of Research on Women's Health (ORWH); Grant numbers:
   NR004061, AG012505, AG012535, AG012531, AG012539, AG012546, AG012553,
   AG012554, AG012495; Grant sponsor: National Cancer Institute; Grant
   numbers: R01CA89552, R25CA90956
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NR 50
TC 20
Z9 21
U1 0
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0020-7136
EI 1097-0215
J9 INT J CANCER
JI Int. J. Cancer
PD OCT 1
PY 2011
VL 129
IS 7
BP 1699
EP 1707
DI 10.1002/ijc.25790
PG 9
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA 798XX
UT WOS:000293246600016
PM 21105041
OA Bronze, Green Accepted
DA 2025-06-11
ER

PT J
AU Dayar, E
   Kara, E
   Yetik-Anacak, G
   Hocaoglu, N
   Bozkurt, O
   Gidener, S
   Durmus, N
AF Dayar, E.
   Kara, E.
   Yetik-Anacak, G.
   Hocaoglu, N.
   Bozkurt, O.
   Gidener, S.
   Durmus, N.
TI Do penile haemodynamics change in the presence of hydrogen sulphide
   (H2S) donor in metabolic syndrome-induced erectile
   dysfunction?
SO ANDROLOGIA
LA English
DT Article
DE erectile dysfunction; fructose; hydrogen sulphide; intracavernous
   pressure; metabolic syndrome
ID CORPUS CAVERNOSUM; PROTEIN EXPRESSION; INSULIN-RESISTANCE; OXIDATIVE
   STRESS; RAT MODEL; RESPONSES; FRUCTOSE; BIOSYNTHESIS; RESVERATROL;
   DEFICIENCY
AB Erectile dysfunction (ED) is defined in relation to the metabolic syndrome (metS). Hydrogen sulphide (H2S), a gasotransmitter, has been revealed to get involved in hypertension, insulin secretion and regulation of vascular tone especially in erectile physiology. This study aimed to investigate the effect of H2S on metS-induced ED. Animals were divided into two groups as control and metS, which were fed with standard diet or 60% high-fructose diet for 10weeks respectively. The metS model was evaluated with biochemical analyses, waist circumference/tibia length ratio and HOMA index. Penile hemodynamic parameters were evaluated by the measurement of intracavernous pressure/mean arterial pressure ratio during cavernous nerve stimulation in the presence and absence of intracavernous injection of NaHS (100g/50l) and its control 0.9%NaCl (50l) in both groups. H2S levels were measured in penile tissues by methylene blue assay. H2S levels were significantly decreased in the penile tissues of the metS group. Decreased intracavernous pressure/mean arterial pressure ratio improved after intracavernous administration of NaHS in the metS group. These results suggest the significant role of H2S in the metS-induced erectile dysfunction that could be a new therapeutic target.
C1 [Dayar, E.; Kara, E.; Hocaoglu, N.; Gidener, S.; Durmus, N.] Dokuz Eylul Univ, Dept Pharmacol, Fac Med, Izmir, Turkey.
   [Yetik-Anacak, G.] Ege Univ, Dept Pharmacol, Fac Med, Izmir, Turkey.
   [Bozkurt, O.] Dokuz Eylul Univ, Dept Urol, Fac Med, Izmir, Turkey.
C3 Dokuz Eylul University; Ege University; Dokuz Eylul University
RP Durmus, N (corresponding author), Dokuz Eylul Univ, Dept Pharmacol, Fac Med, Izmir, Turkey.
EM nrgzdurmus@gmail.com
RI gidener, sedef/NJS-8676-2025; Yetik Anacak, Gunay/A-1418-2018; HOCAOGLU
   AKSAY, NIL/P-4614-2019; Durmus, Nergiz/KAM-1185-2024
OI Yetik Anacak, Gunay/0000-0002-7788-1657; HOCAOGLU AKSAY,
   NIL/0000-0002-7449-6809; GIDENER, SEDEF/0000-0002-5182-9789; Durmus,
   Nergiz/0000-0003-4739-9154
FU Research Foundation of Dokuz Eylul University [2014.KB.SAG.027]
FX Research Foundation of Dokuz Eylul University, Grant/Award Number:
   2014.KB.SAG.027
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NR 48
TC 12
Z9 14
U1 0
U2 26
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0303-4569
EI 1439-0272
J9 ANDROLOGIA
JI Andrologia
PD APR
PY 2018
VL 50
IS 3
AR e12885
DI 10.1111/and.12885
PG 7
WC Andrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA FY0HB
UT WOS:000426490200003
PM 28901567
OA gold
DA 2025-06-11
ER

PT J
AU Butcher, JT
   Goodwill, AG
   Stanley, SC
   Frisbee, JC
AF Butcher, Joshua T.
   Goodwill, Adam G.
   Stanley, Shyla C.
   Frisbee, Jefferson C.
TI Differential Impact of Dilator Stimuli on Increased Myogenic Activation
   of Cerebral and Skeletal Muscle Resistance Arterioles in Obese Zucker
   Rats
SO MICROCIRCULATION
LA English
DT Article
DE regulation of vascular tone; rodent models of metabolic syndrome;
   peripheral resistance; microcirculation
ID METABOLIC SYNDROME; OXYGEN-TENSION; FATTY RAT; EPIDEMIOLOGY;
   CONSTRICTION; INTEGRATION; DEFINITION; RESPONSES; PERFUSION; INSULIN
AB ObjectiveTo use the OZR model of the metabolic syndrome to determine the impact of dilator stimuli on MA of GA and MCA. We tested the hypothesis that increased oxidant stress and TxA(2) exacerbate MA, and prevent its blunting with dilator stimuli, in OZR.
   MethodsGA/MCA from OZR and LZR was pressurized ex vivo. MA was determined under control conditions and following challenge with acetylcholine, hypoxia, and adenosine. Responses were also evaluated after pre-treatment with TEMPOL (antioxidant) and SQ-29548 (PGH(2)/TxA(2) receptor antagonist).
   ResultsMA was increased (and dilator responses decreased) in GA/MCA from OZR, dependent on the endothelium and ROS. In GA, the impact of ROS on MA and dilator effects was largely via TxA(2), while in MCA, this appeared was more dependent on NO bioavailability. Intrinsic responses of GA/MCA to carbacyclin, U46619, and NO donors were similar between strains.
   ConclusionsA developing ROS-based endothelial dysfunction in MCA and GA of OZR contributes to an enhanced MA of these vessels. Although treatment of GA/MCA with TEMPOL attenuates MA in OZR, the mechanistic contributors to altered MA, distal to ROS, differ between the two resistance vessels.
C1 [Butcher, Joshua T.; Goodwill, Adam G.; Stanley, Shyla C.; Frisbee, Jefferson C.] W Virginia Univ, Sch Med, Dept Physiol & Pharmacol, Morgantown, WV 26506 USA.
   [Butcher, Joshua T.; Goodwill, Adam G.; Stanley, Shyla C.; Frisbee, Jefferson C.] W Virginia Univ, Sch Med, Ctr Cardiovasc & Resp Sci, Morgantown, WV 26506 USA.
C3 West Virginia University; West Virginia University
RP Frisbee, JC (corresponding author), W Virginia Univ, Hlth Sci Ctr, Ctr Cardiovasc & Resp Sci, Dept Physiol & Pharmacol, 3152 HSN,1 Med Ctr Dr, Morgantown, WV 26506 USA.
EM jefrisbee@hsc.wvu.edu
RI Butcher, Joshua/ABH-7212-2022; Goodwill, Adam/N-4889-2016
OI Goodwill, Adam/0000-0003-3701-3713; Frisbee,
   Jefferson/0000-0003-2751-0599; Butcher, Joshua/0000-0002-7341-1949
FU National Institutes of Health [NIH T32 HL 90610, RR 2865AR, IDeA P20 GM
   103434]; American Heart Association [AHA EIA 0740129N]
FX This study was supported by grants from the National Institutes of
   Health (NIH T32 HL 90610, RR 2865AR and IDeA P20 GM 103434), the
   American Heart Association (AHA EIA 0740129N). The authors express their
   gratitude for the expert technical assistance from Ms. Milinda James
   from the Department of Physiology and Pharmacology at West Virginia
   University.
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NR 29
TC 16
Z9 21
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1073-9688
EI 1549-8719
J9 MICROCIRCULATION
JI Microcirculation
PD OCT
PY 2013
VL 20
IS 7
BP 579
EP 589
DI 10.1111/micc.12056
PG 11
WC Hematology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Hematology; Cardiovascular System & Cardiology
GA 234BA
UT WOS:000325612800001
PM 23510266
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Abdel-Qader, DH
   Albassam, A
   Taybeh, E
   Al Mazrouei, N
   Meer, SMA
   Al-Kubaisi, KA
   Ibrahim, R
   Elnour, AA
   Ibrahim, OM
   Aburuz, S
AF Abdel-Qader, Derar H.
   Albassam, Abdullah
   Taybeh, Esra'
   Al Mazrouei, Nadia
   Meer, Sara Murad Albarkat
   Al-Kubaisi, Khalid Awad
   Ibrahim, Rana
   Elnour, Asim Ahmed
   Mohamed Ibrahim, Osama
   Aburuz, Salah
TI Lipid and Glucose Profile across Different Mental Disorders
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Article
DE schizophrenia; unipolar depression; bipolar disorder; bipolar mania;
   bipolar depression; lipid and glucose levels
ID METABOLIC SYNDROME; SCHIZOPHRENIA; DEPRESSION; PREVALENCE;
   ANTIPSYCHOTICS; ADULTS; HEALTH
AB Objectives: Schizophrenia, unipolar depression, bipolar disorder, bipolar mania, and bipolar depression are a few of the severe psychiatric diseases that affect millions of individuals and their overall life quality. This study aimed to look at differences in TGA, TC, HDL, LDL, and FPG levels in people who were going through acute episodes of listed diseases. Materials and methods: A cross-sectional prospective study was carried out in Jordan between January and November of 2023, involving all patients with the aforementioned diseases who attended three psychiatric clinics. This study encompassed results from 1187 patients (women N = 675, 56.87%) who were classified into the following ranges: <25, 25-45, 45-65, and >65. Results: The average level of LDL was the highest in bipolar depression (112.442 +/- 36.178 mg/dL) and the lowest in bipolar mania (111.25 +/- 33.14 mg/dL). The average level of HDL was the highest in schizophrenia (58.755 +/- 16.198 mg/dL) and the lowest in bipolar depression (45.584 +/- 12.128 mg/dL). Both average levels of TC and TGA were the highest in patients with bipolar depression (188.403 +/- 37.396 mg/dL and 149.685 +/- 96.951 mg/dL, respectively) and the lowest in bipolar mania (164.790 +/- 40.488 mg/dL and 100.679 +/- 54.337 mg/dL, respectively). The average level of FPG was the highest in unipolar depression (94.00 +/- 21.453 mg/dL) and the lowest in bipolar mania (89.492 +/- 14.700 mg/dL). Conclusions: The results confirmed that lipid and glucose abnormalities were more common in people with schizophrenia and mood disorders (unipolar and bipolar).
C1 [Abdel-Qader, Derar H.] Univ Petra, Fac Pharm & Med Sci, Amman 11196, Jordan.
   [Albassam, Abdullah] Kuwait Univ, Fac Pharm, Dept Pharm Practice, Kuwait 12037, Kuwait.
   [Taybeh, Esra'] Isra Univ, Sch Pharm, Dept Appl Pharmaceut Sci, Amman 11622, Jordan.
   [Al Mazrouei, Nadia; Meer, Sara Murad Albarkat; Al-Kubaisi, Khalid Awad; Ibrahim, Rana] Univ Sharjah, Coll Pharm, Dept Pharm Practice & Pharmacotherapeut, Sharjah, U Arab Emirates.
   [Elnour, Asim Ahmed] Al Ain Univ, Coll Pharm, Abu Dhabi, U Arab Emirates.
   [Elnour, Asim Ahmed] Al Ain Univ, AAU Hlth & Biomed Res Ctr, Abu Dhabi 112612, U Arab Emirates.
   [Mohamed Ibrahim, Osama] New Giza Univ, Sch Pharm, Dept Clin Pharm, Giza 3296121, Egypt.
   [Aburuz, Salah] United Arab Emirates Univ, Coll Med & Hlth Sci, Dept Pharmacol & Therapeut, Al Ain 15551, U Arab Emirates.
C3 Petra University; Kuwait University; Isra University; University of
   Sharjah; Newgiza University (NGU); United Arab Emirates University
RP Aburuz, S (corresponding author), United Arab Emirates Univ, Coll Med & Hlth Sci, Dept Pharmacol & Therapeut, Al Ain 15551, U Arab Emirates.
EM d.balawi@igec.com.au; albassam@hsc.edu.kw; esra.taybeh@iu.edu.jo;
   nalmazrouei@sharjah.ac.ae; smeer@sharjah.ac.ae;
   kalkubaissi@sharjah.ac.ae; ribrahim@sharjah.ac.ae; asim.ahmed@aau.ac.ae;
   osama.hussein@ngu.edu.eg; saburuz@uaeu.ac.ae
RI aburuz, salah/P-4293-2018; Kubaissi, Khalid/GPG-0996-2022; Elnour,
   Asim/ABI-6308-2020; Ibrahim, Omer/R-5485-2018
OI Taybeh, Esra'/0000-0001-7493-7865; Ibrahim, Rana/0000-0002-9104-3852;
   Elnour, Asim/0000-0002-4143-7810; Abdel-Qader, Derar
   H./0000-0003-2576-4464
FU British Council Jordan
FX The authors thank all participants who took part in this study and all
   sub-investigators, study coordinators, and site staff who contributed to
   the conduct of this study.
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NR 17
TC 0
Z9 0
U1 0
U2 1
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD MAY
PY 2024
VL 13
IS 9
AR 2499
DI 10.3390/jcm13092499
PG 15
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA QJ8Y1
UT WOS:001220610100001
PM 38731028
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Zainal, NH
   Newman, MG
AF Zainal, Nur Hani
   Newman, Michelle G.
TI Prospective network analysis of proinflammatory proteins, lipid markers,
   and depression components in midlife community women
SO PSYCHOLOGICAL MEDICINE
LA English
DT Article
DE Cross-lagged; depression; endocrine; immune; inflammation;
   interpersonal; network analysis; scar theory; vulnerability theory
ID PROSPECTIVE ASSOCIATIONS; FUNCTIONAL CONNECTIVITY; METABOLIC SYNDROME;
   SEX-DIFFERENCES; INFLAMMATION; SYMPTOMS; METAANALYSIS; RISK; HEALTH;
   LIFE
AB Background Vulnerability theories propose that suboptimal levels of lipid markers and proinflammatory proteins predict future heightened depression. Scar models posit the reverse association. However, most studies that tested relationships between non-specific immune/endocrine markers and depression did not separate temporal inferences between people and within-person and how different immunometabolism markers related to unique depression symptoms. We thus used cross-lagged prospective network analyses (CLPN) to investigate this topic. Methods Community midlife women (n = 2224) completed the Center for Epidemiologic Studies-Depression scale and provided biomarker samples across five time-points spanning 9 years. CLPN identified significant relations (edges) among components (nodes) of depression (depressed mood, somatic symptoms, interpersonal issues), lipid markers [insulin, fasting glucose, triglycerides, low-density lipoprotein-cholesterol (LDL), high-density lipoprotein-cholesterol (HDL)], and proinflammatory proteins [C-reactive protein (CRP), fibrinogen], within and across time-points. All models adjusted for age, estradiol, follicle-stimulating hormone, and menopausal status. Results In within-person temporal networks, higher CRP and HDL predicted all three depression components (d = 0.131-2.112). Increased LDL preceded higher depressed mood and interpersonal issues (v. somatic symptoms) (d = 0.251-0.327). Elevated triglycerides predicted more somatic symptoms (v. depressed mood and interpersonal problems) (d = 0.131). More interpersonal problems forecasted elevated fibrinogen and LDL levels (d = 0.129-0.331), and stronger somatic symptoms preceded higher fibrinogen levels (d = 0.188). Conclusions Results supported both vulnerability and scar models. Long-term dysregulated immunometabolism systems, social disengagement, and related patterns are possible mechanistic accounts. Cognitive-behavioral therapies that optimize nutrition and physical activity may effectively target depression.
C1 [Zainal, Nur Hani] Harvard Med Sch, Dept Hlth Care Policy, Boston, MA 02115 USA.
   [Newman, Michelle G.] Penn State Univ, Dept Psychol, State Coll, PA 16801 USA.
C3 Harvard University; Harvard Medical School; Pennsylvania Commonwealth
   System of Higher Education (PCSHE); Pennsylvania State University;
   Pennsylvania State University - University Park
RP Newman, MG (corresponding author), Penn State Univ, Dept Psychol, State Coll, PA 16801 USA.
EM mgn1@psu.edu
RI Newman, Michelle G./I-4370-2013
OI Newman, Michelle G./0000-0003-0873-1409
FU National Institute of Mental Health [R01MH115128] Funding Source: NIH
   RePORTER
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NR 114
TC 18
Z9 19
U1 3
U2 37
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0033-2917
EI 1469-8978
J9 PSYCHOL MED
JI Psychol. Med.
PD AUG
PY 2023
VL 53
IS 11
BP 5267
EP 5278
AR PII S003329172200232X
DI 10.1017/S003329172200232X
EA AUG 2022
PG 12
WC Psychology, Clinical; Psychiatry; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA Q6SY3
UT WOS:000836001300001
PM 35924730
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Adarthaiya, S
   Sehgal, A
AF Adarthaiya, Saikrupa
   Sehgal, Amit
TI Moringa oleifera Lam. as a potential plant for alleviation of the
   metabolic syndrome-A narrative review based on in vivo and clinical
   studies
SO PHYTOTHERAPY RESEARCH
LA English
DT Review
DE dyslipidaemia; hyperglycaemia; hypertension; metabolic syndrome;
   moringa; obesity
ID IMPROVES GLUCOSE-TOLERANCE; AQUEOUS LEAF EXTRACT; DIET-INDUCED OBESITY;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; BLOOD-PRESSURE; SEED EXTRACT;
   TOXICOLOGICAL EVALUATION; ANTIOXIDANT ACTIVITY; GLUT4 TRANSLOCATION
AB The metabolic syndrome (MetS) refers to the co-occurrence of risk factors, including hyperglycaemia, increased body weight, hypertension and dyslipidemia, which eventually lead to diabetes and cardiovascular disease, a common health problem worldwide. Recently, there has been an increasing interest in the use of plant-based products for the management of MetS, because of their less detrimental and more beneficial effects. Moringa oleifera (Moringaceae), commonly known as drumstick, is cultivated worldwide for its nutritional and medicinal properties. This review focuses on the in vivo and human studies concerning the potential of M. oleifera in the alleviation of MetS and its comorbidities. The search for relevant articles was carried out in PubMed and Google Scholar databases. Randomised controlled and clinical trials from the PubMed database were included in this review. The results suggested that the administration of M. oleifera, in vivo, shows clear signs of improvement in MetS indices. Despite fewer human studies, the existing data documented convincing results that uphold the potential of M. oleifera against MetS. Therefore, future research discussing the probable mechanism of action is much needed which could further assure the usage of M. oleifera in the treatment regimen of MetS.
C1 [Adarthaiya, Saikrupa; Sehgal, Amit] Lovely Profess Univ, Sch Bioengn & Biosci, Dept Zool, Phagwara, India.
   [Sehgal, Amit] Lovely Profess Univ, Sch Bioengn & Biosci, Dept Zool, Phagwara 144411, Punjab, India.
C3 Lovely Professional University; Lovely Professional University
RP Sehgal, A (corresponding author), Lovely Profess Univ, Sch Bioengn & Biosci, Dept Zool, Phagwara 144411, Punjab, India.
EM sehgalamitres@gmail.com
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NR 209
TC 4
Z9 4
U1 1
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0951-418X
EI 1099-1573
J9 PHYTOTHER RES
JI Phytother. Res.
PD FEB
PY 2024
VL 38
IS 2
BP 755
EP 775
DI 10.1002/ptr.8079
EA NOV 2023
PG 21
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA HV6V6
UT WOS:001110151100001
PM 38015048
DA 2025-06-11
ER

PT J
AU Tomou, EM
   Papakyriakopoulou, P
   Skaltsa, H
   Valsami, G
   Kadoglou, NPE
AF Tomou, Ekaterina-Michaela
   Papakyriakopoulou, Paraskevi
   Skaltsa, Helen
   Valsami, Georgia
   Kadoglou, Nikolaos P. E.
TI Bio-Actives from Natural Products with Potential Cardioprotective
   Properties: Isolation, Identification, and Pharmacological Actions of
   Apigenin, Quercetin, and Silibinin
SO MOLECULES
LA English
DT Review
DE apigenin; quercetin; silibinin; silymarin; isolation; identification;
   cardiovascular disease; diabetes mellitus; hypertension; metabolic
   syndrome
ID MYOCARDIAL ISCHEMIA/REPERFUSION INJURY; ANGIOTENSIN-CONVERTING ENZYME;
   TYPE-2 DIABETES-MELLITUS; OXIDATIVE STRESS; ENDOTHELIAL FUNCTION;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; SILYBUM-MARIANUM;
   GLUCOSE-UPTAKE; ANTIDIABETIC ACTIVITY
AB Cardiovascular diseases (CVDs) are the leading cause of morbidity and mortality worldwide. As a result, pharmaceutical and non-pharmaceutical interventions modifying risk factors for CVDs are a top priority of scientific research. Non-pharmaceutical therapeutical approaches, including herbal supplements, have gained growing interest from researchers as part of the therapeutic strategies for primary or secondary prevention of CVDs. Several experimental studies have supported the potential effects of apigenin, quercetin, and silibinin as beneficial supplements in cohorts at risk of CVDs. Accordingly, this comprehensive review focused critically on the cardioprotective effects/mechanisms of the abovementioned three bio-active compounds from natural products. For this purpose, we have included in vitro, preclinical, and clinical studies associated with atherosclerosis and a wide variety of cardiovascular risk factors (hypertension, diabetes, dyslipidemia, obesity, cardiac injury, and metabolic syndrome). In addition, we attempted to summarize and categorize the laboratory methods for their isolation and identification from plant extracts. This review unveiled many uncertainties which are still unexplored, such as the extrapolation of experimental results to clinical practice, mainly due to the small clinical studies, heterogeneous doses, divergent constituents, and the absence of pharmacodynamic/pharmacokinetic analyses.
C1 [Tomou, Ekaterina-Michaela; Papakyriakopoulou, Paraskevi; Skaltsa, Helen; Valsami, Georgia] Natl & Kapodistrian Univ Athens, Sch Hlth Sci, Dept Pharm, Athens 15784, Greece.
   [Kadoglou, Nikolaos P. E.] Univ Cyprus, Med Sch, CY-2029 Nicosia, Cyprus.
C3 National & Kapodistrian University of Athens; University of Cyprus
RP Kadoglou, NPE (corresponding author), Univ Cyprus, Med Sch, CY-2029 Nicosia, Cyprus.
EM nikoskad@yahoo.com
RI Kadoglou, Nikolaos/AAA-8639-2021; Valsami, Georgia/AAB-4710-2020
OI Tomou, Ekaterina-Michaela/0000-0002-4313-9657; Papakyriakopoulou,
   Paraskevi/0000-0003-0566-0713; Valsami, Georgia/0000-0002-2395-6844;
   Kadoglou, Nikolaos/0000-0002-7830-3488
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NR 202
TC 19
Z9 19
U1 1
U2 17
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1420-3049
J9 MOLECULES
JI Molecules
PD MAR
PY 2023
VL 28
IS 5
AR 2387
DI 10.3390/molecules28052387
PG 32
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 9U3CI
UT WOS:000947593100001
PM 36903630
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Holmannova, D
   Borsky, P
   Borska, L
   Andrys, C
   Hamakova, K
   Rehacek, V
   Svadlakova, T
   Malkova, A
   Beranek, M
   Palicka, V
   Krejsek, J
   Fiala, Z
AF Holmannova, Drahomira
   Borsky, Pavel
   Borska, Lenka
   Andrys, Ctirad
   Hamakova, Kvetoslava
   Rehacek, Vit
   Svadlakova, Tereza
   Malkova, Andrea
   Beranek, Martin
   Palicka, Vladimir
   Krejsek, Jan
   Fiala, Zdenek
TI Metabolic Syndrome, Clusterin and Elafin in Patients with Psoriasis
   Vulgaris
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE psoriasis; metabolic syndrome; clusterin; elafin
ID ELASTASE-SPECIFIC INHIBITOR; NEUTROPHIL ELASTASE; STRESS;
   RETROTRANSLOCATION; INFLAMMATION; EXPRESSION; SECRETION; LEVEL; ALPHA;
   CELLS
AB Background: Psoriasis is a pathological condition characterized by immune system dysfunction and inflammation. Patients with psoriasis are more likely to develop a wide range of disorders associated with inflammation. Serum levels of various substances and their combinations have been associated with the presence of the disease (psoriasis) and have shown the potential to reflect its activity. The aim of the present study is to contribute to the elucidation of pathophysiological links between psoriasis, its pro-inflammatory comorbidity metabolic syndrome (MetS), and the expression of clusterin and elafin, which are reflected in the pathophysiological "portfolio" of both diseases. Material and methods: Clinical examinations (PASI score), ELISA (clusterin, elafin), and biochemical analyses (parameters of MetS) were performed. Results: We found that patients with psoriasis were more often afflicted by MetS, compared to the healthy controls. Clusterin and elafin levels were higher in the patients than in the controls but did not correlate to the severity of psoriasis. Conclusion: Our data suggest that patients with psoriasis are more susceptible to developing other systemic inflammatory diseases, such as MetS. The levels of clusterin and elafin, which are tightly linked to inflammation, were significantly increased in the patients, compared to the controls, but the presence of MetS in patients did not further increase these levels.
C1 [Holmannova, Drahomira; Borsky, Pavel; Svadlakova, Tereza; Malkova, Andrea; Beranek, Martin; Fiala, Zdenek] Charles Univ Prague, Fac Med Hradec Kralove, Inst Hyg & Prevent Med, Hradec Kralove 50038, Czech Republic.
   [Borsky, Pavel; Borska, Lenka] Charles Univ Prague, Fac Med Hradec Kralove, Inst Pathol Physiol, Hradec Kralove 50003, Czech Republic.
   [Andrys, Ctirad; Svadlakova, Tereza; Krejsek, Jan] Charles Univ Prague, Univ Hosp, Inst Clin Immunol & Allergol, Hradec Kralove 50005, Czech Republic.
   [Andrys, Ctirad; Svadlakova, Tereza; Beranek, Martin; Palicka, Vladimir; Krejsek, Jan] Charles Univ Prague, Fac Med Hradec Kralove, Hradec Kralove 50005, Czech Republic.
   [Hamakova, Kvetoslava] Univ Hosp Hradec Kralove, Clin Dermatol & Venereol, Hradec Kralove 50005, Czech Republic.
   [Rehacek, Vit] Univ Hosp, Transfus Ctr, Hradec Kralove 50005, Czech Republic.
   [Beranek, Martin; Palicka, Vladimir] Charles Univ Prague, Univ Hosp Hradec Kralove, Inst Clin Biochem & Diagnost, Hradec Kralove 50005, Czech Republic.
C3 University Hospital Hradec Kralove; Charles University Prague;
   University Hospital Hradec Kralove; Charles University Prague;
   University Hospital Hradec Kralove; Charles University Prague;
   University Hospital Hradec Kralove; Charles University Prague;
   University Hospital Hradec Kralove; University Hospital Hradec Kralove;
   University Hospital Hradec Kralove; Charles University Prague
RP Borsky, P (corresponding author), Charles Univ Prague, Fac Med Hradec Kralove, Inst Hyg & Prevent Med, Hradec Kralove 50038, Czech Republic.; Borsky, P (corresponding author), Charles Univ Prague, Fac Med Hradec Kralove, Inst Pathol Physiol, Hradec Kralove 50003, Czech Republic.
EM holmd9ar@lfhk.cuni.cz; borskyp@lfhk.cuni.cz; borka@lfhk.cuni.cz;
   andrys@fnhk.cz; kveta@hamakova.cz; RehacekV@lfhk.cuni.cz;
   svadlakovat@lfhk.cuni.cz; MALKA8AR@lfhk.cuni.cz; Beranek@lfhk.cuni.cz;
   Palicka@lfhk.cuni.cz; KrejsekJ@lfhk.cuni.cz; Fiala@lfhk.cuni.cz
RI Palicka, Vladimir/N-1802-2017; Rehacek, Vit/H-4564-2018; Fiala,
   Zdeněk/E-5962-2017; Krejsek, Jan/AAQ-6561-2021; Holmannova,
   Drahomira/G-6260-2017; Beranek, Martin/A-9644-2017; Malkova,
   Andrea/B-1013-2017; Borsky, Pavel/S-6307-2016; Borska,
   Lenka/S-6304-2016; Svadlakova, Tereza/E-5562-2017
OI Beranek, Martin/0000-0002-7422-722X; Malkova,
   Andrea/0000-0001-9444-8065; Borsky, Pavel/0000-0001-5253-2808;
   Holmannova, Drahomira/0000-0002-9865-9991; Borska,
   Lenka/0000-0002-8580-1485; Svadlakova, Tereza/0000-0002-1581-5531
FU Charles University, Faculty of Medicine in Hradec Kralove, the Czech
   Republic [Q40-09, Q40-10, Q40-11, SVV-260543 2020]
FX This researchwas funded by Charles University, Faculty of Medicine in
   Hradec Kralove, the Czech Republic, by projects Q40-09, Q40-10, Q40-11,
   and SVV-260543 2020.
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NR 66
TC 18
Z9 18
U1 0
U2 8
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD AUG
PY 2020
VL 21
IS 16
AR 5617
DI 10.3390/ijms21165617
PG 13
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA NI0PL
UT WOS:000565061100001
PM 32764517
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Agbozo, F
   Bannerman, E
   Klomegah, S
   Zotor, F
AF Agbozo, Faith
   Bannerman, Edith
   Klomegah, Senam
   Zotor, Francis
TI Lifestyle habits and perceived wellbeing of adults presenting with
   metabolic syndrome at a diabetic clinic in Ghana: A case-control study
SO HUMAN NUTRITION & METABOLISM
LA English
DT Article
DE Metabolic syndrome; Obesity; Hypertension; Diabetes; Diet; Lifestyle
   habits; Wellbeing; Quality of life; Ghana
ID QUALITY-OF-LIFE; DIETARY PATTERNS; PREVALENCE
AB Background: Heightened by the epidemiological transition associated with excess energy intake, sedentary lifestyle and urbanisation, metabolic syndrome (MetS), previously uncommon in sub-Sahara Africa, is increasingly becoming a public health concern. Methods: We retrospectively assessed the association of diet and socio-demographic indicators as exposure factors to the development of MetS in typical peri-urban and rural settings in Ghana and examined the effect of MetS on the perceived quality of life of patients. One-on-one age- and sex-matched case-control study involving 152 adults aged 45-65 years were recruited from a diabetic clinic. Controls were recruited from communities where cases resided. Case definition was concurrent adiposity, hypertension, diabetes and dyslipidaemia. Lifestyle was assessed using a lifestyle and habits questionnaire, whereas diet history was assessed using a food frequency questionnaire. Differences were tested using McNemar and paired t-tests. To determine which exposure variables significantly predicted the development of MetS, we conducted a conditional logistic regression and reported the Mantel Haenszel crude and adjusted odds ratio (OR). Results: Markers for MetS among the cases and controls were abdominal obesity (98.7% vs 36.8%), hypertension (90.8% vs 2.6%) and diabetes (72.4% vs 1.3%). Controls (77.6%) consumed more diversified diets compared to the cases (10.5%) (p = 0.001). Lower risk for MetS was linked to secondary education (COR = 0.17) and long duration of residence (COR = 0.30) in a peri-urban setting (COR = 0.22) whereas being unemployed (COR = 9.00) increased the risk. Abdominal obesity (COR = 28.51) was a stronger predictor of MetS compared to BMI & GE;30 kg/m2 (COR = 14.80). Comparatively, the controls had a better self-perception of their physical wellbeing (73.7% vs 2.6%), fitness (88.2% vs 13.2%), nutrition and weight control (14.5% vs 1.3%) and psychological health (19.7% vs 0%). Conclusion: Considering that socio-demographic indicators were key exposures to MetS, we recommend interventions that promote the holistic wellbeing of the individual and should be integrated into existing health, social and community-based support services.
C1 [Agbozo, Faith; Bannerman, Edith; Klomegah, Senam; Zotor, Francis] Univ Hlth & Allied Hlth Sci, Sch Publ Hlth, Dept Family & Community Hlth, Ho, Ghana.
   [Agbozo, Faith] Univ Hlth & Allied Hlth Sci, Sch Publ Hlth, Dept Family & Community Hlth, Private Mail Bag 31, Ho, Ghana.
RP Agbozo, F (corresponding author), Univ Hlth & Allied Hlth Sci, Sch Publ Hlth, Dept Family & Community Hlth, Private Mail Bag 31, Ho, Ghana.
EM faagbozo@uhas.edu.gh
RI Agbozo, Faith/AAR-9466-2021
OI Agbozo, Faith/0000-0001-7707-5658; Bannerman, Edith
   Kabukie/0009-0009-9639-9610
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NR 28
TC 0
Z9 0
U1 1
U2 2
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2666-1497
J9 HUM NUTR METAB
JI Hum. Nutr. Metab.
PD SEP
PY 2022
VL 29
AR 200154
DI 10.1016/j.hnm.2022.200154
PG 8
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA R0QA5
UT WOS:001061462800002
OA gold
DA 2025-06-11
ER

PT J
AU Leung, KC
   Bakr, B
   Chung, CY
   Parmar, M
   Elhindi, J
   Brakoulias, V
AF Leung, Kelvin CY.
   Bakr, Bianca
   Chung, Cindy
   Parmar, Mayuri
   Elhindi, James
   Brakoulias, Vlasios
TI A streamlined multidisciplinary metabolic clinic in psychiatric recovery
   service: a pilot study
SO FRONTIERS IN PSYCHIATRY
LA English
DT Article
DE metabolic syndrome; mental health consumers; streamlined approach;
   multidisciplinary team; inpatient program
ID ILLNESS; HEALTH
AB Background The metabolic syndrome (MetS) is a collection of risk factors for cardiovascular disease and type-2 diabetes, that includes central obesity, hypertension, hyperglycaemia and dyslipidaemia. An audit indicated inadequate MetS screening in an Australian psychiatric recovery service.Objectives We aimed to improve MetS screening, identification and intervention by offering streamlined lifestyle education, clinical reviews and discharge planning. This pilot program prioritized holistic, culturally-sensitive, patient-centric, and trauma-informed approaches to enhance metabolic health outcomes.Methods A Metabolic Clinic was piloted in two psychiatric rehabilitation cottages (n=35), which involved disciplines of dietetics, exercise physiology, diversional therapy, occupational therapy, peer workforce, social work, clinical psychology, pharmacy, nursing and medical. Another cottage (n=15) was assigned as the comparison and received standard care. A 12-week, 3-times-per-week lifestyle and behavioral program, called MetFit, was devised and offered to those identified at screening for the treatment cottages. Outcome measures were feasibility measures, the five metabolic parameters (waist circumference, blood pressure, fasting serum triglycerides, high-density lipoprotein, and glucose), functional measures, and a meal questionnaire.Results The treatment cottages had qualitative advantages in screening and identifying MetS. Of four enrolled consumers in MetFit, an improvement of triglycerides (p=0.08), squats (p=0.02), and push-ups (p=0.07) was observed. Major challenges of enrolment included an overall lack of acknowledgment of its importance, poor motivation of consumers and resources limitation.Conclusions The one-stop provision of groups, peer support and inpatient pathway with multidisciplinary team-integration was generally accepted by consumers and the MDT and has iteratively demonstrated the urgent need for consumer-centered physical care and a cultural shift to foster collaboration within a psychiatric service.
C1 [Leung, Kelvin CY.; Bakr, Bianca; Chung, Cindy; Parmar, Mayuri] Cumberland Hosp, Recovery Serv, WSLHD, Sydney, NSW, Australia.
   [Leung, Kelvin CY.] Res & Educ Network, WSLHD, Sydney, NSW, Australia.
   [Leung, Kelvin CY.; Elhindi, James; Brakoulias, Vlasios] Univ Sydney, Fac Med & Hlth, Sydney, NSW, Australia.
   [Brakoulias, Vlasios] Western Sydney Univ, Sch Med, Sydney, NSW, Australia.
   [Brakoulias, Vlasios] Western Sydney Univ, Translat Hlth Res Inst, Sydney, NSW, Australia.
C3 University of Sydney; Western Sydney University; Western Sydney
   University
RP Leung, KC (corresponding author), Cumberland Hosp, Recovery Serv, WSLHD, Sydney, NSW, Australia.; Leung, KC (corresponding author), Res & Educ Network, WSLHD, Sydney, NSW, Australia.; Leung, KC (corresponding author), Univ Sydney, Fac Med & Hlth, Sydney, NSW, Australia.
EM kelvin.leung1@health.nsw.gov.au
RI Brakoulias, Vlasios/N-1603-2019
OI Brakoulias, Vlasios/0000-0002-4188-4370
FU Otsuka Psychiatry Research Grant; WSLHD Research and Education Network
   Grant
FX The author(s) declare financial support was received for the research,
   authorship, and/or publication of this article. This work was supported
   by the Otsuka Psychiatry Research Grant 2021 and the WSLHD Research and
   Education Network Grant 2022.
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NR 21
TC 0
Z9 0
U1 2
U2 4
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-0640
J9 FRONT PSYCHIATRY
JI Front. Psychiatry
PD FEB 20
PY 2024
VL 15
AR 1344453
DI 10.3389/fpsyt.2024.1344453
PG 10
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA JV2J3
UT WOS:001175869000001
PM 38445084
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Sokrateva, T
   Roussev, B
   Nashar, M
   Salim, A
   Ivanova, D
AF Sokrateva, Todorka
   Roussev, Bogdan
   Nashar, Milka
   Salim, Ayshe
   Ivanova, Diana
TI Mineral Waters with a Potential to Control and Prevent Metabolic
   Syndrome: A Systematic Review
SO BALNEO AND PRM RESEARCH JOURNAL
LA English
DT Review
DE mineral water; water intake; metabolic syndrome; obesity; prevention
ID ANGIOTENSIN-ALDOSTERONE SYSTEM; DRINKING-WATER; OXIDATIVE STRESS;
   BLOOD-PRESSURE; RICH WATER; CALCIUM BIOAVAILABILITY; POSTPRANDIAL
   LIPEMIA; INSULIN-RESISTANCE; CALORIC BEVERAGES; SULFUROUS WATER
AB The morbidity rate of metabolic syndrome (MetS) has increased alarmingly in recent years. The intake of mineral water is among the recommendations for a healthy lifestyle in overweight people. The aim of the study was to investigate the effects of mineral water intake on MetS variables such as lipid status, blood pressure, blood glucose levels, and antioxidant defense. The PRISMA guidelines were followed, focusing on the period from 1990 to 2024. Twenty-four studies met the inclusion criteria. Among these, sixteen were randomized controlled crossover trials, one was crossover, six were interventional, and one was of a cyclic type. The included studies were divided by duration into long-term with mineral water intake for at least one month, postprandial, and treatment including mineral water intake. Mineral waters have been tested according to different protocols regarding water composition, amount consumed, with or without changes in lifestyle and diet in healthy subjects or such with impaired biochemical parameters. Regular mineral water intake may have a positive effects on lipid metabolism, blood pressure, glycemic status, and the antioxidant system. These findings can be used as an additional alternative treatment method in risk groups with MetS, obesity, or hyperglycemia.
C1 [Sokrateva, Todorka; Roussev, Bogdan; Nashar, Milka; Salim, Ayshe; Ivanova, Diana] Med Univ Varna, Fac Pharm, Dept Biochem Mol Med & Nutrigen, Varna, Bulgaria.
C3 Medical University Varna
RP Sokrateva, T (corresponding author), Med Univ Varna, Fac Pharm, Dept Biochem Mol Med & Nutrigen, Varna, Bulgaria.
EM sokrateva@mu-varna.bg
FU European Union-NextGenerationEU through the National Recovery and
   Resilience Plan of the Republic of Bulgaria [BGRRP-2.004-0009C02]
FX This research was funded by the European Union-NextGenerationEU through
   the National Recovery and Resilience Plan of the Republic of Bulgaria,
   project no. BGRRP-2.004-0009C02, Research group 3.1.1., Natura4Health.
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NR 121
TC 0
Z9 0
U1 0
U2 0
PU ROMANIAN ASSOC BALNEOLOGY
PI BUCHAREST
PA SECTOR 2, ALEEA DOBRINA NO 7, BL D10, SC A, AP 4, BUCHAREST, ROMANIA
SN 2734-844X
EI 2734-8458
J9 BALNEO PRM RES J
JI Balneo PRM Res. J.
PD MAR
PY 2025
VL 16
IS 1
AR 773
DI 10.12680/balneo.2025.773
PG 32
WC Rehabilitation
WE Emerging Sources Citation Index (ESCI)
SC Rehabilitation
GA 3IQ6I
UT WOS:001501257600031
DA 2025-06-11
ER

PT J
AU Rodríguez-Correa, E
   González-Pérez, I
   Clavel-Pérez, PI
   Contreras-Vargas, Y
   Carvajal, K
AF Rodriguez-Correa, Eduardo
   Gonzalez-Perez, Imelda
   Clavel-Perez, Pedro Isauro
   Contreras-Vargas, Yolanda
   Carvajal, Karla
TI Biochemical and nutritional overview of diet-induced metabolic syndrome
   models in rats: what is the best choice?
SO NUTRITION & DIABETES
LA English
DT Review
ID HIGH-FAT-DIET; HIGH-FRUCTOSE DIET; INDUCED INSULIN-RESISTANCE; BROWN
   ADIPOSE-TISSUE; HIGH-CARBOHYDRATE; INDUCED OBESITY; CAFETERIA DIET;
   OXIDATIVE STRESS; HYPERTENSIVE-RATS; SUCROSE DIET
AB Metabolic syndrome (MS) is a condition that includes obesity, insulin resistance, dyslipidemias among other, abnormalities that favors type 2 Diabetes Mellitus (T2DM) and cardiovascular diseases development. Three main diet-induced metabolic syndrome models in rats exist: High carbohydrate diet (HCHD), high fat diet (HFD), and high carbohydrate-high fat diet (HCHHFD). We analyzed data from at least 35 articles per diet, from different research groups, to determine their effect on the development of the MS, aimed to aid researchers in choosing the model that better suits their research question; and also the best parameter that defines obesity, as there is no consensus to determine this condition in rats. For the HCHD we found a mild effect on body weight gain and fasting blood glucose levels (FBG), but significant increases in triglycerides, fasting insulin, insulin resistance and visceral fat accumulation. HFD had the greater increase in the parameters previously mentioned, followed by HCHHFD, which had a modest effect on FBG levels. Therefore, to study early stages of MS a HCHD is recommended, while HFD and HCHHFD better reproduce more severe stages of MS. We recommend the assessment of visceral fat accumulation as a good estimate for obesity in the rat.
C1 [Rodriguez-Correa, Eduardo; Gonzalez-Perez, Imelda; Clavel-Perez, Pedro Isauro; Contreras-Vargas, Yolanda; Carvajal, Karla] Inst Nacl Pediat, Lab Nutr Expt, Mexico City, DF, Mexico.
RP Carvajal, K (corresponding author), Inst Nacl Pediat, Lab Nutr Expt, Mexico City, DF, Mexico.
EM karla_ca@yahoo.com
OI Contreras-Vargas, Yolanda/0000-0002-7514-8590; Clavel-Perez, Pedro
   Isauro/0000-0001-7573-9414; Rodriguez-Correa,
   Eduardo/0000-0001-9069-682X
FU CONACYT [619938, 614768]
FX E.R.C. received a scholarship from CONACYT number 619938. I.G.P.
   received a scholarship from CONACYT number 614768. We would like to
   thank Dr. Fernando Gomez-Chavez for the assistance with the figures
   using the Bio Render software.
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NR 142
TC 92
Z9 94
U1 2
U2 32
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 2044-4052
J9 NUTR DIABETES
JI Nutr. Diabetes
PD JUL 2
PY 2020
VL 10
IS 1
AR 24
DI 10.1038/s41387-020-0127-4
PG 15
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA ME9SB
UT WOS:000544993200001
PM 32616730
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Jurgonski, A
   Juskiewicz, J
   Zdunczyk, Z
AF Jurgonski, Adam
   Juskiewicz, Jerzy
   Zdunczyk, Zenon
TI Ingestion of Black Chokeberry Fruit Extract Leads to Intestinal and
   Systemic Changes in a Rat Model of Prediabetes and Hyperlipidemia
SO PLANT FOODS FOR HUMAN NUTRITION
LA English
DT Article
DE Anthocyanins; Metabolic syndrome; Disaccharidase; Polyphenols; Rat model
ID ARONIA-MELANOCARPA; FRUCTOSE; DIET; JUICE
AB This report presents a complex analysis of changes proceeding in the gut, blood and internal organs of rats with induced oxidative stress, glucose intolerance and hyperlipidemia after dietary supplementation with an extract from black chokeberry (Aronia melanocarpa) fruit, that is a condensed source of polyphenols (714 mg/g), especially anthocyanin glycosides (56.6%). The disturbances mimicking those observed in metabolic syndrome were induced by a high-fructose diet and simultaneous single injection of streptozotocin (20 mg/kg). Dietary supplementation with the chokeberry fruit extract (0.2%) decreased activity of maltase and sucrase as well as increased activity of lactase in the mucosa of the small intestine. Its ingestion led also to the improvement of antioxidant status, especially, the concentration of a lipid peroxidation indicator (TBARS) in organ tissues (liver, kidney and lung) was normalized; some cholesterol-lowering and distinct hypoglycemic actions were also observed. The mechanism of glucose reduction is likely to be multifactorial, and we suggest the factors related with the decreased activity of mucosal disaccharidases important for further investigation. In Conclusion, chokebeny fruit derivatives may act as a promising supplementary therapeutic option in the prevention and treatment of disorders occurring in metabolic syndrome, as well as their complications.
C1 [Jurgonski, Adam; Juskiewicz, Jerzy; Zdunczyk, Zenon] Polish Acad Sci, Inst Anim Reprod & Food Res, Dept Biol Anal Food, PL-10747 Olsztyn, Poland.
C3 Polish Academy of Sciences; Institute of Animal Reproduction & Food
   Research of the Polish Academy of Sciences
RP Jurgonski, A (corresponding author), Polish Acad Sci, Inst Anim Reprod & Food Res, Dept Biol Anal Food, Tuwima 10, PL-10747 Olsztyn, Poland.
EM adam@pan.olsztyn.pl
RI JURGONSKI, Adam/A-5864-2009; JUSKIEWICZ, Jerzy/H-7193-2017; ZDUNCZYK,
   Zenon/H-7272-2017
OI JURGONSKI, Adam/0000-0003-3524-3259; JUSKIEWICZ,
   Jerzy/0000-0003-0068-5970; ZDUNCZYK, Zenon/0000-0002-0640-7552
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NR 26
TC 95
Z9 113
U1 2
U2 27
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0921-9668
EI 1573-9104
J9 PLANT FOOD HUM NUTR
JI Plant Food Hum. Nutr.
PD DEC
PY 2008
VL 63
IS 4
BP 176
EP 182
DI 10.1007/s11130-008-0087-7
PG 7
WC Plant Sciences; Chemistry, Applied; Food Science & Technology; Nutrition
   & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Chemistry; Food Science & Technology; Nutrition &
   Dietetics
GA 403FP
UT WOS:000263068800005
PM 18726160
DA 2025-06-11
ER

PT J
AU Elbanna, RHM
   Elabd, SOA
   Saleh, MSM
   Alghitany, SIA
AF Elbanna, Rana Hesham Mohamed
   Elabd, Sherif Osama Abdelsalam
   Saleh, Marwa Shafiek Mustafa
   Alghitany, Salma Ibrahim Abdelmohsen
TI Effect of adding noninvasive auricular Vagal nerve stimulation to
   exercise program on emotional eating and stress responsiveness in
   patient with metabolic syndrome
SO DISABILITY AND REHABILITATION
LA English
DT Article; Early Access
DE Vagal nerve stimulations; eating disorder; patient satisfaction;
   hydrocortisone; Metabolic syndrome
ID PHYSICAL-ACTIVITY; CORTISOL; ASSOCIATION; SYSTEM
AB PurposeTo evaluate the effects of vagus nerve stimulation (VNS) on selected health-related outcomes in MetS.MethodsSeventy men with metabolic syndrome (MetS) aged between 45 and 55, with a body mass index (BMI) ranging from 30 to 35 kg/m2, were randomly divided into study group that received a vagus nerve stimulation (VNS) and circuit weight training (CWT) and control group which underwent a CWT. An Emotional Eating Scale (EES) and a Short Assessment of Patient Satisfaction (SAPS) were used to evaluate emotional eating and patient satisfaction with their therapy, respectively. Salivary cortisol levels were measured between 8 and 9 am, and body weight was detected after 8 h of fasting. The clinical trial ID was NCT05785117.ResultsThere was a significant change in EES and SAPS scale scores in both groups post-intervention; however, the study group showed higher scores than the control group. Furthermore, the change percentage of weight and salivary cortisol in the study group was 8.9% and 44.5%, respectively, which were higher than in the control group (2.9% and 40.6%, respectively).ConclusionVNS and CWT were considered promising, simple, and cost-effective interventions for improving emotional eating, patient satisfaction, salivary cortisol, and body weight in individuals with MetS.
C1 [Elbanna, Rana Hesham Mohamed; Alghitany, Salma Ibrahim Abdelmohsen] Cairo Univ, Fac Phys Therapy, Phys Therapy Internal Med Dept, Giza, Egypt.
   [Elabd, Sherif Osama Abdelsalam] May Univ, Fac Phys Therapy, Phys Therapy Internal Med Dept, Cairo, Egypt.
   [Saleh, Marwa Shafiek Mustafa] Cairo Univ, Fac Phys Therapy, Basic Sci Dept, Cairo, Egypt.
C3 Egyptian Knowledge Bank (EKB); Cairo University; Egyptian Knowledge Bank
   (EKB); Cairo University
RP Elbanna, RHM (corresponding author), Cairo Univ, Fac Phys Therapy, Phys Therapy Internal Med Dept, Giza, Egypt.
EM rana.hesham@pt.cu.edu.eg
RI saleh, marwa/KBA-5561-2024
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NR 56
TC 0
Z9 0
U1 0
U2 0
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0963-8288
EI 1464-5165
J9 DISABIL REHABIL
JI Disabil. Rehabil.
PD 2025 MAY 16
PY 2025
DI 10.1080/09638288.2025.2506824
EA MAY 2025
PG 8
WC Rehabilitation
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Rehabilitation
GA 2RU8X
UT WOS:001489784400001
PM 40382680
DA 2025-06-11
ER

PT J
AU Yu, J
   Shen, JY
   Sun, TT
   Zhang, X
   Wong, N
AF Yu, Jun
   Shen, Jiayun
   Sun, Ting Ting
   Zhang, Xiang
   Wong, Nathalie
TI Obesity, insulin resistance, NASH and hepatocellular carcinoma
SO SEMINARS IN CANCER BIOLOGY
LA English
DT Review
DE Hepatocellular carcinoma; NASH; Metabolic syndrome; Insulin resistance;
   Obesity
ID NONALCOHOLIC FATTY LIVER; GROWTH-FACTOR 21; NATURAL-HISTORY;
   CANCER-RISK; HISTOLOGICAL SEVERITY; DISEASE PROGRESSION;
   DIABETES-MELLITUS; HEPATIC STEATOSIS; CELL-DEATH; TNF-ALPHA
AB Epidemiological and clinical data have clearly demonstrated that non-alcoholic steatohepatitis (NASH) predisposes risk to the development of hepatocellular carcinoma (HCC). NASH is the liver manifestation of metabolic syndrome, which constellates obesity, insulin resistance and dyslipidemia. Although the percentage of patients diagnosed annually with NASH-associated HCC is still relatively low, this number signifies a large population due to the rapidly increasing incidence of obesity and diabetes globally. Fundamental studies on lipid storage, regulation of adipose factors, inflammatory cytokine recruitments and oxidative stress have provided insights into NASH as well as metabolic syndrome. Recent evidence also indicates the significant role of genetic factors in contributing to the pathogenesis of NASH and induced hepatic malignancy. In this review, we attempt to collate current research on NASH biology that lead to our understandings on how metabolic disorders may intersect with cancer development. We also discuss study models that have supported discoveries of molecular and cellular defects, and offered a perspective on therapeutic developments. These studies have collectively increased our knowledge on the complex signaling pathways involved in NASH and cancer, and provided the foundation for improved clinical management of patients with metabolic diseases. (C) 2013 Elsevier Ltd. All rights reserved.
C1 [Yu, Jun; Shen, Jiayun; Zhang, Xiang] Chinese Univ Hong Kong, Inst Digest Dis, Li Ka Shing Inst Hlth Sci, Shatin, Hong Kong, Peoples R China.
   [Yu, Jun; Shen, Jiayun; Zhang, Xiang] Chinese Univ Hong Kong, Dept Med & Therapeut, Li Ka Shing Inst Hlth Sci, Shatin, Hong Kong, Peoples R China.
   [Sun, Ting Ting; Wong, Nathalie] Chinese Univ Hong Kong, Dept Anat & Cellular Pathol, Shatin, Hong Kong, Peoples R China.
   [Wong, Nathalie] Chinese Univ Hong Kong, State Key Lab Oncol South China, Shatin, Hong Kong, Peoples R China.
C3 Chinese University of Hong Kong; Chinese University of Hong Kong;
   Chinese University of Hong Kong; State Key Lab Oncology South China;
   Chinese University of Hong Kong
RP Yu, J (corresponding author), Chinese Univ Hong Kong, Dept Med & Therapeut, Hong Kong, Hong Kong, Peoples R China.
EM junyu@cuhk.edu.hk; natwong@cuhk.edu.hk
RI Tingting, Sun/AAU-7019-2021; ZHANG, Xiang/N-7918-2015; Jun,
   Yu/D-8569-2015
OI Jun, Yu/0000-0001-5008-2153
FU Hong Kong Research Grants Council [T12-403/11]
FX This study was support by a Theme-based Research Scheme from the Hong
   Kong Research Grants Council (Ref. No.: T12-403/11).
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NR 108
TC 125
Z9 143
U1 1
U2 43
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 1044-579X
EI 1096-3650
J9 SEMIN CANCER BIOL
JI Semin. Cancer Biol.
PD DEC
PY 2013
VL 23
IS 6
BP 483
EP 491
DI 10.1016/j.semcancer.2013.07.003
PN B
PG 9
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA 280EP
UT WOS:000329011800003
PM 23876851
DA 2025-06-11
ER

PT J
AU Chang, CC
   Fang, WH
   Chang, HA
   Chen, TY
   Huang, SY
AF Chang, Chuan-Chia
   Fang, Wen-Hui
   Chang, Hsin-An
   Chen, Tien-Yu
   Huang, San-Yuan
TI Sex-Specific Association Between Nerve Growth Factor Polymorphism and
   Cardiac Vagal Modulation
SO PSYCHOSOMATIC MEDICINE
LA English
DT Article
DE nerve growth factor; polymorphism; autonomic nervous system; heart rate
   variability
ID HEART-RATE-VARIABILITY; POWER SPECTRUM ANALYSIS; NEUROTROPHIC FACTORS;
   SYMPATHOVAGAL BALANCE; METABOLIC SYNDROME; ANXIETY; NGF; EXPRESSION;
   ESTROGEN; BEHAVIOR
AB Objective Substantial research has shown that anxiety disorders are associated with decreased cardiac vagal tone, which is a known risk factor for cardiac vulnerability. A functional nerve growth factor (NGF) polymorphism (rs6330, c.104C > T, p.Ala35Val) has been associated with anxiety such that in males but not females, T-allele carriers exhibit higher levels of trait anxiety. Here we investigate whether the nonsynonymous NGF variant has an effect on cardiac autonomic control.
   Methods From 705 adults initially screened for medical and psychiatric illnesses, a final cohort of 580 healthy Han Chinese (352 men, 228 women; mean [standard deviation] age = 34.46 [8.45] years) was included in the NGF genotyping (C/C: 428% [73.8%] and T-allele carriers: 152% [26.2%]). Short-term heart rate variability was used to assess cardiac autonomic function.
   Results There were significant genotype-by-sex interaction effects (p < .05) on high-frequency power (HF) and root mean square of successive heartbeat interval differences (RMSSD), both indices of cardiac vagal control. Even after adjusting for possible confounders, men with any T allele showed lower HF and RMSSD compared with men with the C/C genotype. Women, however, showed an opposite but nonsignificant pattern.
   Conclusions The studied NGF polymorphism modulates autonomic outflow to the heart in a sex-dependent manner. The findings support the view that male T-allele carriers are at increased susceptibility for anxiety by association with low vagal activity and suggest a potential sex-specific genetic link between the highly comorbid anxiety disorders and cardiovascular diseases.
C1 [Chang, Chuan-Chia; Chang, Hsin-An; Chen, Tien-Yu; Huang, San-Yuan] Tri Serv Gen Hosp, Natl Def Med Ctr, Dept Psychiat, Taipei 114, Taiwan.
   [Fang, Wen-Hui] Tri Serv Gen Hosp, Natl Def Med Ctr, Dept Family & Community Med, Taipei 114, Taiwan.
   [Chang, Chuan-Chia; Huang, San-Yuan] Natl Def Med Ctr, Grad Inst Med Sci, Taipei, Taiwan.
C3 Tri-Service General Hospital; National Defense Medical Center;
   Tri-Service General Hospital; National Defense Medical Center; National
   Defense Medical Center
RP Huang, SY (corresponding author), Tri Serv Gen Hosp, Dept Psychiat, Grad Inst Med Sci, Natl Def Med Ctr, 325,Sec 2,Cheng Kung Rd, Taipei 114, Taiwan.
EM hsy@ndmctsgh.edu.tw
RI Cheng, Yeung/AFN-3087-2022; Chen, Han-Shen/E-5881-2018
OI Chang, Hsin-An/0000-0001-5572-7109; Chen, Tien-Yu/0000-0001-8462-1311
FU Tri-Service General Hospital [TSGH-C101-120, TSGH-C102-122,
   TSGH-C103-130]
FX This research was supported by grants from Tri-Service General Hospital
   (TSGH-C101-120, TSGH-C102-122, and TSGH-C103-130). The authors report no
   conflicts of interest.
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NR 60
TC 20
Z9 20
U1 0
U2 8
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0033-3174
EI 1534-7796
J9 PSYCHOSOM MED
JI Psychosom. Med.
PD OCT
PY 2014
VL 76
IS 8
BP 638
EP 643
DI 10.1097/PSY.0000000000000091
PG 6
WC Psychiatry; Psychology; Psychology, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry; Psychology
GA AR9HK
UT WOS:000343883900008
PM 25162994
DA 2025-06-11
ER

PT J
AU Yoon, J
   Kim, J
   Son, H
AF Yoon, Jaehee
   Kim, Jeewuan
   Son, Heesook
TI Gender Differences of Health Behaviors in the Risk of Metabolic Syndrome
   for Middle-Aged Adults: A National Cross-Sectional Study in South Korea
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Article
DE gender differences; metabolic syndrome; health practice index;
   middle-aged
AB This study examined gender differences in health behaviors for the risk of metabolic syndrome (MetS) among middle-aged adults using nationally representative data from the Seventh Korea National Health and Nutrition Examination Survey (2016-2018). The sample included data from 8677 middle-aged adults. The Health Practice Index measured health behaviors, including smoking, alcohol use, physical activity, sleeping, eating breakfast, working hours, nutritionally balanced diet, and mental stress. Complex sample multiple logistic regression analyses were conducted to determine the association between the Health Practice Index (HPI) and MetS. Men and women with poor or moderate HPI scores had significantly higher risks of having MetS than those with good HPI scores. Controlling for covariates, high-risk alcohol use (p < 0.001) and physical activity (p = 0.008) were associated with the risk of MetS in men and women, respectively. Men reporting alcohol use and women lacking a healthy diet were, respectively, 2.056 times (adjusted odds ratio (OR) = 2.056, 95% CI: 1.681-2.514) and 1.306 times (adjusted OR = 1.306, 95% CI: 1.075-1.587) more likely to have increased risks of MetS. Given these gender differences in health behaviors, developing tailored interventions could be beneficial in preventing MetS among middle-aged men and women.
C1 [Yoon, Jaehee] Wolchon Elementary Sch, Seoul 07980, South Korea.
   [Kim, Jeewuan] Yonsei Univ, Dept Stat & Data Sci, Seoul 03722, South Korea.
   [Son, Heesook] Chung Ang Univ, Red Cross Coll Nursing, Seoul 06974, South Korea.
C3 Yonsei University; Chung Ang University
RP Son, H (corresponding author), Chung Ang Univ, Red Cross Coll Nursing, Seoul 06974, South Korea.
EM rnyjh@snu.ac.kr; jeewuan@yonsei.ac.kr; hson@cau.ac.kr
RI Yoon, Jaehee/AAP-1159-2021
OI YOON, JAEHEE/0000-0001-9826-8408
FU National Research Foundation of Korea Grant - Korean Government
   [NRF-2019R1A2C1006716]
FX This work was supported by a National Research Foundation of Korea Grant
   funded by the Korean Government (NRF-2019R1A2C1006716).
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NR 54
TC 6
Z9 6
U1 1
U2 9
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD APR
PY 2021
VL 18
IS 7
AR 3699
DI 10.3390/ijerph18073699
PG 16
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA RK8EM
UT WOS:000638522400001
PM 33916247
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Gonçalves, AS
   Andrade, N
   Martel, F
AF Goncalves, Ana S.
   Andrade, Nelson
   Martel, Fatima
TI Intestinal fructose absorption: Modulation and relation to human
   diseases
SO PHARMANUTRITION
LA English
DT Article
DE Fructose; Intestinal absorption; GLUT5; GLUT2; Metabolic syndrome;
   Cancer
ID AGE-ASSOCIATED CHANGES; RAT SMALL-INTESTINE; DIETARY FRUCTOSE;
   MESSENGER-RNA; METABOLIC SYNDROME; OXIDATIVE STRESS; HIGH-FAT;
   ADIPOSE-TISSUE; CORN SYRUP; URIC-ACID
AB Background: Fructose is a hexose sugar found naturally in our diet and excessive fructose consumption has been documented in humans over the last decades. Fructose absorption in the small intestine is a highly regulated process and GLUT5 plays an essential role in this process, but GLUT2 is also involved.
   Methods: In this review, we will describe the multiple mechanisms involved in the regulation of intestinal fructose absorption and the effects of excessive consumption of this sugar on human health.
   Results: Excessive fructose intake is associated with a growing incidence of certain diseases, including obesity, type 2 diabetes, non-alcoholic fatty liver disease, cardiac disease, gastrointestinal disorders, and cancer. It is also associated with changes in gut integrity and microbiota.
   Conclusions: High fructose consumption is associated with the development of characteristics of metabolic syndrome and of other diseases such as cardiomyopathies, kidney disease and tumor growth, in both humans and rodents So, modulation of GLUT5and/or GLUT2-mediated intestinal fructose absorption might provide a novel pharmacologic strategy for the treatment of these diseases. However, most of the data on high fructose consumption has been obtained in rodent models, and so more studies are needed in order to fully confirm these observations in humans.
C1 [Goncalves, Ana S.; Andrade, Nelson; Martel, Fatima] Univ Porto, Fac Med, Unit Biochem, Dept Biomed, P-4200319 Porto, Portugal.
   [Andrade, Nelson; Martel, Fatima] Univ Porto, Inst Invest & Inovacao Saude i3S, Porto, Portugal.
   [Andrade, Nelson] Univ Porto, Fac Pharm, Dept Chem Sci, REQUIMTE LAQV, Porto, Portugal.
C3 Universidade do Porto; Universidade do Porto; i3S - Instituto de
   Investigacao e Inovacao em Saude, Universidade do Porto; Universidade do
   Porto
RP Martel, F (corresponding author), Univ Porto, Fac Med, Unit Biochem, Dept Biomed, P-4200319 Porto, Portugal.
EM fmartel@med.up.pt
RI Andrade, Nelson/AAK-3763-2021; Martel, Felix/JFJ-0587-2023; Gonçalves,
   ana/JJF-8262-2023
OI Martel, Fatima/0000-0002-0525-3416; Andrade, Nelson/0000-0003-2600-8599
FU FCT-Fundacao para a Ciencia e a Tecnologia (Instituto de Investigacao e
   Inovacao em Saude, Universidade do Porto, Portugal)
   [(UID/BIM/04293/2013)]
FX F. Martel acknowledges funding from FCT-Fundacao para a Ciencia e a
   Tecnologia (Instituto de Investigacao e Inovacao em Saude, Universidade
   do Porto, Portugal (UID/BIM/04293/2013)).
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NR 155
TC 4
Z9 4
U1 3
U2 18
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2213-4344
J9 PHARMANUTRITION
JI PharmaNutrition
PD DEC
PY 2020
VL 14
AR 100235
DI 10.1016/j.phanu.2020.100235
PG 9
WC Chemistry, Medicinal; Geriatrics & Gerontology; Gerontology; Nutrition &
   Dietetics; Pharmacology & Pharmacy
WE Emerging Sources Citation Index (ESCI)
SC Pharmacology & Pharmacy; Geriatrics & Gerontology; Nutrition & Dietetics
GA PE2DL
UT WOS:000598179700006
DA 2025-06-11
ER

PT J
AU Ramirez-Higuera, A
   Quevedo-Corona, L
   Paniagua-Castro, N
   Chamorro-Ceballos, G
   Milliar-Garcia, A
   Jaramillo-Flores, ME
AF Ramirez-Higuera, Abril
   Quevedo-Corona, Lucia
   Paniagua-Castro, Norma
   Chamorro-Ceballos, German
   Milliar-Garcia, Angel
   Jaramillo-Flores, Maria E.
TI Antioxidant enzymes gene expression and antihypertensive effects of
   seaweeds Ulva linza and Lessonia trabeculata in rats fed a
   high-fat and high-sucrose diet
SO JOURNAL OF APPLIED PHYCOLOGY
LA English
DT Article
DE Ulva linza; Lessonia trabeculata; Chlorophyta; Phaeophyta; Metabolic
   syndrome; Hypertension; Gene expression
ID METABOLIC SYNDROME; OXIDATIVE STRESS; LIPID-METABOLISM; OBESITY;
   FUCOXANTHIN; GLUCOSE; EXTRACT
AB The objective of this work was to evaluate the antihypertensive and antioxidant effect of seaweeds (Ulva linza and Lessonia trabeculata) in rats which were fed a hypercaloric diet. Seaweed at 400 mg kg(-1) of body weight was administered for 8 weeks to Wistar rats that were fed with a standard diet or a hypercaloric diet. Intra-abdominal fat, insulin resistance, and lipid profile of the rats were determined. Liver was isolated to determine antioxidant enzymes [superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx)] activity and gene expression. The administration of seaweed to the rats reduced the levels of intra-abdominal fat, arterial blood pressure, insulin resistance, and cholesterol and triglyceride serum levels. U. linza reduced the GPx activity in control animals but increased it in animals with MS, which could be reduced by using L. trabeculata. Both seaweeds diminished the SOD and GPx expression and increased CAT in control group. Both seaweeds reduced the CAT expression in animals with metabolic syndrome. Combined effects of the different compounds found in the seaweeds explain the regulating effect over different antioxidant enzymes and metabolic pathways that protect the animals fed a hypercaloric diet against the development of hypertension, hyperglycemia, and obesity.
C1 [Ramirez-Higuera, Abril; Jaramillo-Flores, Maria E.] Escuela Nacl Ciencias Biolg, Inst Politecn Nacl, Casco De Santo Tomas 11340, Mexico.
   [Quevedo-Corona, Lucia; Paniagua-Castro, Norma] Escuela Nacl Ciencias Biolg, Inst Politecn Nacl, Dept Fisiol, Casco De Santo Tomas 11340, Mexico.
   [Chamorro-Ceballos, German] Escuela Nacl Ciencias Biolg, Inst Politecn Nacl, Dept Farm, Casco De Santo Tomas 11340, Mexico.
   [Milliar-Garcia, Angel] Escuela Nacl Ciencias Biolg, Inst Politecn Nacl, Secc Estudios Posgrad & Invest, Casco De Santo Tomas 11340, Mexico.
C3 Instituto Politecnico Nacional - Mexico; Instituto Politecnico Nacional
   - Mexico; Instituto Politecnico Nacional - Mexico; Instituto Politecnico
   Nacional - Mexico
RP Jaramillo-Flores, ME (corresponding author), Escuela Nacl Ciencias Biolg, Inst Politecn Nacl, Carpio Plan Ayala S-N, Casco De Santo Tomas 11340, Mexico.
EM Jaramillo_flores@hotmail.com
FU SIP/IPN; SCYTDF [SIP20131019, SIP20131172, SIP20131522, PICSA12-036];
   PIFI, CONACYT
FX The authors would like to acknowledge SIP/IPN and SCYTDF (grant
   SIP20131019; SIP20131172; SIP20131522; PICSA12-036) for the financial
   support. ARH is grateful to PIFI, CONACYT for a graduate scholarship.
   LQ, NPC, HR, AMG, and MEJ are SNI, EDI/IPN, and COFAA/IPN fellows.
CR Amengual J, 2011, PLOS ONE, V6, DOI 10.1371/journal.pone.0020644
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   World Health Organization (WHO), Obesity and overweight
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NR 22
TC 19
Z9 21
U1 0
U2 50
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0921-8971
EI 1573-5176
J9 J APPL PHYCOL
JI J. Appl. Phycol.
PD FEB
PY 2014
VL 26
IS 1
BP 597
EP 605
DI 10.1007/s10811-013-0134-0
PG 9
WC Biotechnology & Applied Microbiology; Marine & Freshwater Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Marine & Freshwater Biology
GA AA3CF
UT WOS:000330969800063
DA 2025-06-11
ER

PT J
AU Ackerman, Z
   Oron-Herman, M
   Pappo, O
   Peleg, E
   Safadi, R
   Schmilovitz-Weiss, H
   Grozovski, M
AF Ackerman, Zvi
   Oron-Herman, Mor
   Pappo, Orit
   Peleg, Edna
   Safadi, Rifaat
   Schmilovitz-Weiss, Hemda
   Grozovski, Maria
TI Hepatic Effects of Rosiglitazone in Rats with the Metabolic Syndrome
SO BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
LA English
DT Article
ID FATTY LIVER-DISEASE; PLACEBO-CONTROLLED TRIAL; NONALCOHOLIC
   STEATOHEPATITIS; INSULIN-RESISTANCE; OXIDATIVE STRESS; GENE-EXPRESSION;
   ADIPOSE-TISSUE; TROGLITAZONE; MICE; PIOGLITAZONE
AB Rats given fructose-enriched diet develop many characteristics of the human metabolic syndrome and non-alcoholic fatty liver disease. In this study, we characterized the hepatic effects of rosiglitazone in fructose-enriched diet rats. Rats were randomly divided into three groups. One group was maintained on standard rat chow diet for 6 weeks, whereas the other two groups were given fructose-enriched diet for 6 weeks. Four weeks after the initiation of fructose-enriched diet, one of the fructose-enriched diet groups was also given rosiglitazone (10 mg/kg/day) for an additional 2 weeks. Rosiglitazone administration to the fructose-enriched diet rats was associated with decreases in the following parameters: blood pressure (-17%), plasma triglycerides (-62%), hepatic total lipids (-19%), hepatic triglycerides (-61%), hepatic malondialdehyde (-88%), glutathione reductase activity (-84%). An increase in adiponectin plasma levels (+329%), hepatic phospholipids (+46%), hepatic alpha-tocopherol concentrations (+24%) and hepatic paraoxonase activity (+68%) was observed. Rosiglitazone caused a decrease in hepatic macrovesicular steatosis score but no change in hepatic fibrosis. Administration of rosiglitazone, to rats with the metabolic syndrome has limited hepatic favourable effects: it improves hepatic lipid metabolism, decreases macrovesicular steatosis and improves some of the hepatic oxidative-anti-oxidative milieu but has no effect on hepatic fibrosis.
C1 [Ackerman, Zvi] Hadassah Hebrew Univ, Med Ctr, Dept Med, IL-91240 Jerusalem, Israel.
   [Oron-Herman, Mor; Peleg, Edna] Chaim Sheba Med Ctr, Hypertens Unit, IL-52621 Tel Hashomer, Israel.
   [Pappo, Orit] Hadassah Hebrew Univ, Med Ctr, Dept Pathol, IL-91240 Jerusalem, Israel.
   [Safadi, Rifaat] Hadassah Hebrew Univ, Med Ctr, Liver Unit, IL-91240 Jerusalem, Israel.
   [Schmilovitz-Weiss, Hemda] Hasharon Hosp, Rabin Med Ctr, Gastroenterol Unit, Liver Inst, IL-49372 Petah Tiqwa, Israel.
   [Grozovski, Maria] Ort Braude Coll Engn, Dept Biotechnol, Karmiel, Israel.
C3 Hebrew University of Jerusalem; Hadassah University Medical Center;
   Chaim Sheba Medical Center; Hebrew University of Jerusalem; Hadassah
   University Medical Center; Hebrew University of Jerusalem; Hadassah
   University Medical Center; Rabin Medical Center; Braude Academic College
   of Engineering
RP Ackerman, Z (corresponding author), Hadassah Hebrew Univ, Med Ctr, Dept Med, Mt Scopus Campus,POB 24035, IL-91240 Jerusalem, Israel.
EM zackerman@hadassah.org.il
OI Safadi, Rifaat/0000-0002-8689-5217
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NR 46
TC 36
Z9 38
U1 0
U2 4
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-7835
EI 1742-7843
J9 BASIC CLIN PHARMACOL
JI Basic Clin. Pharmacol. Toxicol.
PD AUG
PY 2010
VL 107
IS 2
BP 663
EP 668
DI 10.1111/j.1742-7843.2010.00553.x
PG 6
WC Pharmacology & Pharmacy; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Toxicology
GA 626BB
UT WOS:000279939600006
PM 20210788
OA Bronze
DA 2025-06-11
ER

PT J
AU Lohr, M
   Folkmann, JK
   Sheykhzade, M
   Jensen, LJ
   Kermanizadeh, A
   Loft, S
   Moller, P
AF Lohr, Mille
   Folkmann, Janne K.
   Sheykhzade, Majid
   Jensen, Lars J.
   Kermanizadeh, Ali
   Loft, Steffen
   Moller, Peter
TI Hepatic Oxidative Stress, Genotoxicity and Vascular Dysfunction in Lean
   or Obese Zucker Rats
SO PLOS ONE
LA English
DT Article
ID FATTY LIVER-DISEASE; DIESEL EXHAUST PARTICLES; DNA-DAMAGE;
   8-OXO-7,8-DIHYDRO-2'-DEOXYGUANOSINE EXCRETION; NONALCOHOLIC
   STEATOHEPATITIS; ENDOTHELIAL DYSFUNCTION; INSULIN-RESISTANCE; METABOLIC
   SYNDROME; GLYCEMIC CONTROL; GENE-EXPRESSION
AB Metabolic syndrome is associated with increased risk of cardiovascular disease, which could be related to oxidative stress. Here, we investigated the associations between hepatic oxidative stress and vascular function in pressurized mesenteric arteries from lean and obese Zucker rats at 14, 24 and 37 weeks of age. Obese Zucker rats had more hepatic fat accumulation than their lean counterparts. Nevertheless, the obese rats had unaltered age-related level of hepatic oxidatively damaged DNA in terms of formamidopyrimidine DNA glycosylase (FPG) or human oxoguanine DNA glycosylase (hOGG1) sensitive sites as measured by the comet assay. There were decreasing levels of oxidatively damaged DNA with age in the liver of lean rats, which occurred concurrently with increased expression of Ogg1. The 37 week old lean rats also had higher expression level of Hmox1 and elevated levels of DNA strand breaks in the liver. Still, both strain of rats had increased protein level of HMOX1 in the liver at 37 weeks. The external and lumen diameters of mesenteric arteries increased with age in obese Zucker rats with no change in media cross-sectional area, indicating outward re-modelling without hypertrophy of the vascular wall. There was increased maximal response to acetylcholine-mediated endothelium-dependent vasodilatation in both strains of rats. Collectively, the results indicate that obese Zucker rats only displayed a modest mesenteric vascular dysfunction, with no increase in hepatic oxidative stress-generated DNA damage despite substantial hepatic steatosis.
C1 [Lohr, Mille; Folkmann, Janne K.; Kermanizadeh, Ali; Loft, Steffen; Moller, Peter] Univ Copenhagen, Environm Hlth Sect, Dept Publ Hlth, DK-1014 Copenhagen K, Denmark.
   [Sheykhzade, Majid] Univ Copenhagen, Fac Hlth & Med Sci, Dept Drug Design & Pharmacol, DK-2100 Copenhagen O, Denmark.
   [Jensen, Lars J.] Fac Hlth & Med Sci, Dept Vet Clin & Anim Sci, DK-1870 Frederiksberg C, Denmark.
C3 University of Copenhagen; University of Copenhagen
RP Moller, P (corresponding author), Univ Copenhagen, Environm Hlth Sect, Dept Publ Hlth, Oster Farimagsgade 5A, DK-1014 Copenhagen K, Denmark.
EM pemo@sund.ku.dk
RI Jensen, Lars/A-9340-2008; Kermanizadeh, Ali/AAD-6281-2019; Kermanizadeh,
   Ali/L-9691-2017
OI Jensen, Lars Jorn/0000-0003-4559-7456; Kermanizadeh,
   Ali/0000-0002-2989-9078; Sheykhzade, Majid/0000-0002-4561-0326; Loft,
   Steffen/0000-0001-9552-8518
FU Danish Research Councils
FX Funding provided by Danish Research Councils. The funders had no role in
   study design, data collection and analysis, decision to publish, or
   preparation of the manuscript.
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NR 53
TC 10
Z9 11
U1 0
U2 4
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAR 4
PY 2015
VL 10
IS 3
AR e0118773
DI 10.1371/journal.pone.0118773
PG 19
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA CC9JM
UT WOS:000350685900068
PM 25738756
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Ion, RM
   Sibianu, M
   Neagoe, R
   Sala, D
   Beresescu, F
   Daniealopol, V
   Daniealopol, R
   Muresan, M
AF Ion, Razvan Marius
   Sibianu, Melania
   Neagoe, Radu
   Sala, Daniela
   Beresescu, Felicia
   Daniealopol, Valentin
   Daniealopol, Ruxandra
   Muresan, Mircea
TI The role of nitro oxidative factors in metabolic dysfunctions: A link
   between severe obesity and weight-loss treatment - a narrative review
SO REVISTA ROMANA DE MEDICINA DE LABORATOR
LA English
DT Review
DE bariatric surgery; oxidative stress; inflammation biomarkers; severe
   obesity
AB Introduction: Metabolic syndrome (MS) is linked to oxidative stress and intracellular redox imbalance, both triggered by chronic inflammatory conditions. The aim of our research was to figure out if bariatric surgery changes the production of free radicals in obese people. In addition, the relationship between metabolic syndrome(MS) and associated conditions is represented by oxidative stress (OS) and intracellular redox imbalance, both of which are induced by the chronic inflammatory conditions that define MS. Methods: The literature search was conducted on PubMed, Cochrane Library, and ScienceDirect, using terms related to severe obesity, nitro-oxidative factors, pro-inflammatory status and reactive oxygen species. Six studies were included. We included papers published till 2022, with a concentration on more recent publications (January 2019 to December 2022). Results: Studies that analyzed the status of the patient after bariatric surgery at 1, 2, 3, 6, 12 months were included in the review, regarding inflammation: CRP levels,IL-6, and regarding oxidative stress: MPO serum activity, blood plasma proteins: dityrosine, kynurenine, glycophore, amyloid and Amadori products, had been found strongly statistically significant decreased at each periodic analyze, the same thing applied to regulatory hormones such as leptin, and due to the fact that these patients have the possibility to keep their weight stable for a longer period, all these factors kept their levels low even 4 years after the intervention. Conclusion: Bariatric surgery is an efficient and quick solution in increasing the quality of life.
C1 [Ion, Razvan Marius; Daniealopol, Ruxandra] George Emil Palade Univ Med Pharm Sci & Technol Ta, Mures Cty Emergency Hosp, Doctoral Sch Med, Dept Surg 2, Targu Mures, Romania.
   [Sibianu, Melania] George Emil Palade Univ Med Pharm Sci & Technol Ta, Fac Pharm, Internal Med, Targu Mures, Romania.
   [Neagoe, Radu; Sala, Daniela; Daniealopol, Valentin] George Emil Palade Univ Med Pharm Sci & Technol Ta, Mures Cty Emergency Hosp, Fac Med, Dept Surg 2, Targu Mures, Romania.
   [Beresescu, Felicia] George Emil Palade Univ Med Pharm Sci & Technol Ta, Fac Dent, Dept Morphol Teeth & Dent Arches, Targu Mures, Romania.
   [Muresan, Mircea] George Emil Palade Univ Med Pharm Sci & Technol Ta, Fac Med English, Anat Dept, Targu Mures, Romania.
RP Sibianu, M (corresponding author), George Emil Palade Univ Med Pharm Sci & Technol Ta, Fac Pharm, Internal Med, Targu Mures, Romania.
EM melaniasibianu@gmail.com
RI Ion, Razvan Marius/IAM-3721-2023; Sala, Daniela Tatiana/IAM-2498-2023;
   Muresan, Mircea/LXV-0408-2024; Beresescu, Felicia/MCY-6709-2025; N,
   Radu/AAE-6364-2022; Daniealopol, Ruxandra/NGS-5901-2025; Daniealopol,
   Valentin/JVZ-1974-2024
OI Daniealopol, Valentin/0009-0003-4675-107X; Muresan,
   Mircea/0000-0002-5262-8524
FU George Emil Palade University of Medicine, Pharmacy, Science, and
   Technology of Targu Mures, Romania [294/4/14.01.2020]
FX This work was supported by the George Emil Palade University of
   Medicine, Pharmacy, Science, and Technology of Targu Mures, Romania,
   Research Grant Number 294/4/14.01.2020.
CR Abad-Jiménez Z, 2020, ANTIOXIDANTS-BASEL, V9, DOI 10.3390/antiox9080734
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NR 24
TC 0
Z9 0
U1 1
U2 1
PU SCIENDO
PI WARSAW
PA BOGUMILA ZUGA 32A, WARSAW, MAZOVIA, POLAND
SN 1841-6624
EI 2284-5623
J9 REV ROMANA MED LAB
JI Rev. Romana Med. Lab.
PD APR 1
PY 2024
VL 32
IS 2
BP 135
EP 142
DI 10.2478/rrlm-2024-0012
PG 8
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA TG9D4
UT WOS:001240221800002
OA gold
DA 2025-06-11
ER

PT J
AU Zhou, X
   Kang, C
   Hu, YH
   Wang, XC
AF Zhou, Xue
   Kang, Chen
   Hu, YuHong
   Wang, XingChen
TI Study on insulin resistance and ischemic cerebrovascular disease: A
   bibliometric analysis via CiteSpace
SO FRONTIERS IN PUBLIC HEALTH
LA English
DT Review
DE insulin resistance; ischemic cerebrovascular disease; association;
   oxidative stress; inflammation; CiteSpace
ID TRIGLYCERIDE-GLUCOSE INDEX; INDEPENDENT RISK-FACTOR; NONDIABETIC
   PATIENTS; METABOLIC SYNDROME; SECONDARY PREVENTION; STROKE; SENSITIVITY;
   PIOGLITAZONE; EVENTS; ATTACK
AB BackgroundIt is reported that insulin resistance widely exists in non-diabetic patients with a recent history of transient ischemic attack (TIA) or ischemic stroke. There is currently strong evidence to prove the bidirectional effect of glucose metabolism disorders and stroke events. Therefore, it is necessary to retrospectively tease out the current status, hotspots, and frontiers of insulin resistance and ischemic cerebrovascular disease through CiteSpace. Materials and methodsWe searched the Web of Science (WOS) for studies related to insulin resistance and ischemic cerebrovascular disease from 1999 to April 2022, then downloaded the data into CiteSpace to generate a knowledge visualization map. ResultsA total of 1,500 publications relevant to insulin resistance and ischemic cerebrovascular disease were retrieved. The USA had the most articles on this topic, followed by PEOPLES R CHINA and JAPAN. WALTER N KERNAN was the most prolific author, whose research mainly focused on insulin resistance intervention after stroke (IRIS) trial. The most common keywords were myocardial ischemia, metabolic syndrome, ischemic stroke, cerebral ischemia, association, oxidative stress, inflammation, and adipose tissue. Major ongoing research trends include three aspects: (1) the association between insulin resistance and ischemic cerebrovascular disease in non-diabetic patients, (2) the intrinsic pathological mechanism between insulin resistance and ischemic cerebrovascular disease, and (3) early intervention of insulin resistance to improve the prognosis of stroke. ConclusionThe results of this bibliometric study provide the current status and trends of clinical research publications in the field of insulin resistance and ischemic cerebrovascular disease. Insulin resistance is strongly associated with the occurrence of ischemic stroke, early neurological deterioration in stroke patients, post-stroke depression, and cerebral small vessel disease. Early treatment of insulin resistance can be an effective way to prevent the onset of ischemic stroke and improve stroke prognosis. This study may help researchers to identify hot topics and explore new research directions.
C1 [Zhou, Xue] Shandong Univ Tradit Chinese Med, Clin Med Coll 1, Jinan, Peoples R China.
   [Kang, Chen] Shandong Univ Tradit Chinese Med, Div Neurol, Affiliated Hosp, Jinan, Peoples R China.
   [Hu, YuHong] 960th Hosp PLA Joint Logist Support Force, Div Cardiol, Jinan, Peoples R China.
   [Wang, XingChen] Shandong Univ Tradit Chinese Med, Dept Neurol, Affiliated Hosp 2, Jinan, Peoples R China.
   [Wang, XingChen] Shandong Univ Tradit Chinese Med, Clin Med Coll 2, Jinan, Peoples R China.
C3 Shandong University of Traditional Chinese Medicine; Shandong University
   of Traditional Chinese Medicine; Shandong University of Traditional
   Chinese Medicine; Shandong University of Traditional Chinese Medicine
RP Wang, XC (corresponding author), Shandong Univ Tradit Chinese Med, Dept Neurol, Affiliated Hosp 2, Jinan, Peoples R China.; Wang, XC (corresponding author), Shandong Univ Tradit Chinese Med, Clin Med Coll 2, Jinan, Peoples R China.
EM sdlcwxc@163.com
FU Natural Science Foundation of Shandong Province [ZR2020MH156]; National
   Famous Old Chinese Medicine Experts Inheritance Studio Construction
   Project; National Chinese Medicine Human Education Letter [2022] [75]
FX Funding This study was supported by the Natural Science Foundation of
   Shandong Province (Grant Number: ZR2020MH156) and the National Famous
   Old Chinese Medicine Experts Inheritance Studio Construction Project
   (Grant Number: National Chinese Medicine Human Education Letter [2022]
   No. 75).
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NR 71
TC 22
Z9 22
U1 14
U2 99
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 2296-2565
J9 FRONT PUBLIC HEALTH
JI Front. Public Health
PD MAR 6
PY 2023
VL 11
AR 1021378
DI 10.3389/fpubh.2023.1021378
PG 14
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA 9Y8KX
UT WOS:000950704800001
PM 36950100
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Haeiwa, H
   Fujita, T
   Saitoh, Y
   Miwa, N
AF Haeiwa, Haruna
   Fujita, Takashi
   Saitoh, Yasukazu
   Miwa, Nobuhiko
TI Oleic acid promotes adaptability against oxidative stress in 3T3-L1
   cells through lipohormesis
SO MOLECULAR AND CELLULAR BIOCHEMISTRY
LA English
DT Article
DE Oleic acid; Fatty acid quantity; Fatty acid quality; Lipid peroxidation;
   Cell injury; Lipohormesis
ID POLYUNSATURATED FATTY-ACIDS; LIPID-PEROXIDATION; INSULIN-RESISTANCE;
   ADAPTIVE RESPONSE; METABOLIC SYNDROME; INDUCED APOPTOSIS; UP-REGULATION;
   DAMAGE; HYDROPEROXIDE; OBESITY
AB Although fatty acids are important components of biological membranes, energy sources, and signal transducers or precursors of lipid mediators, excess intake of fatty acids and their accumulation cause obesity and metabolic syndrome. Thus, fatty acid quantity is known to be an important factor for obesity-related diseases, but the effects of different types of fatty acids (i.e., fatty acid quality) on human health are not completely understood. We here focused on the relationship between fatty acid quality and oxidative stress by investigating whether resistibility to tert-butyl hydrperoxide (t-BuOOH)-induced oxidative stress in 3T3-L1 cells varied according to the fatty acid type. Among eight fatty acids (both saturated and unsaturated) tested, oleic acid (OA) exerted the most pronounced cytoprotective effects, with efficacy over a wide range of concentrations. OA treatment markedly enhanced the intracellular levels of lipid peroxidation markers, including N-epsilon-(hexanoyl) lysine, 4-hydroxy-2-nonenal, and acrolein. The levels of these markers in OA-treated cells were decreased after t-BuOOH exposure, whereas the levels in untreated control cells were notably increased after t-BuOOH exposure. Our results suggested that unsaturated fatty acids, particularly OA, could promote an adaptive response and enhance cell tolerance through increased cellular antioxidative capacity via OA-induced mild lipid peroxidation (lipohormesis), and thus protect cells against subsequent oxidative stress-related injury.
C1 [Haeiwa, Haruna; Fujita, Takashi; Saitoh, Yasukazu] Prefectural Univ Hiroshima, Lab Biosci & Biotechnol Cell Funct Control, Fac Life & Environm Sci, Shobara, Hiroshima 7270023, Japan.
   [Miwa, Nobuhiko] Butsuryo Coll Osaka, Fac Hlth Sci, Sakai, Osaka 5938324, Japan.
RP Saitoh, Y (corresponding author), Prefectural Univ Hiroshima, Lab Biosci & Biotechnol Cell Funct Control, Fac Life & Environm Sci, 562 Nanatsuka, Shobara, Hiroshima 7270023, Japan.
EM ysaito@pu-hiroshima.ac.jp
RI saitoh, yasukazu/AAQ-6432-2021
OI Saitoh, Yasukazu/0000-0002-6288-7634
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NR 49
TC 32
Z9 34
U1 0
U2 8
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0300-8177
EI 1573-4919
J9 MOL CELL BIOCHEM
JI Mol. Cell. Biochem.
PD JAN
PY 2014
VL 386
IS 1-2
BP 73
EP 83
DI 10.1007/s11010-013-1846-9
PG 11
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA AA1AL
UT WOS:000330828400007
PM 24234346
DA 2025-06-11
ER

PT J
AU Lovrencic, MV
   Pibernik-Okanovic, M
   Sekerija, M
   Prasek, M
   Ajdukovic, D
   Kos, J
   Hermanns, N
AF Lovrencic, Marijana Vucic
   Pibernik-Okanovic, Mirjana
   Sekerija, Mario
   Prasek, Manja
   Ajdukovic, Dea
   Kos, Jadranka
   Hermanns, Norbert
TI Improvement in Depressive Symptoms Is Associated with Reduced Oxidative
   Damage and Inflammatory Response in Type 2 Diabetic Patients with
   Subsyndromal Depression: The Results of a Randomized Controlled Trial
   Comparing Psychoeducation, Physical Exercise, and Enhanced Treatment as
   Usual
SO INTERNATIONAL JOURNAL OF ENDOCRINOLOGY
LA English
DT Article
ID COGNITIVE-BEHAVIORAL THERAPY; SERUM URIC-ACID; METABOLIC SYNDROME;
   SIALIC-ACID; GLYCEMIC CONTROL; STRESS; HEALTH; PEOPLE; INSIGHTS;
   OUTCOMES
AB Aims. To examine one-year changes in oxidative damage and inflammation level in type 2 diabetic patients undergoing behavioral treatment for subsyndromal depression. Materials and Methods. A randomized controlled comparison of psychoeducation (A), physical exercise (B), and enhanced treatment as usual (C) was performed in 209 eligible subjects in a tertiary diabetes care setting. Depressive symptoms (primary outcome) and selected biomarkers of oxidative damage and inflammation (secondary outcomes) were assessed at baseline and six-and twelve-month follow-up. Results. Out of the 74, 67, and 68 patients randomised into groups A, B, and C, respectively, 201 completed the interventions, and 179 were analysed. Participants in all three groups equally improved in depressive symptoms from baseline to one-year follow-up (repeated measures ANOVA; F = 12.51, P < 0.0001, eta(2) = 0.07). Urinary 8-oxo-deoxyguanosine (u-8-oxodG) decreased (F = 10.66, p < 0.0001, eta(2) = 0.06), as did sialic acid and leukocytes (F = 84.57, eta(2) = 0.32 and F = 12.61, eta(2) = 0.07, resp.; p < 0.0001), while uric acid increased (F = 12.53, p < 0.0001, eta(2) = 0.07) in all subjects during one year. Improvement of depressive symptoms at 6 months significantly predicted one-year reduction in u-8-oxodG (beta = 0.15, p = 0.044). Conclusion. Simple behavioral interventions are capable not only of alleviating depressive symptoms, but also of reducing the intensity of damaging oxidative/inflammatory processes in type 2 diabetic patients with subsyndromal depression. This trial is registered with ISRCTN05673017.
C1 [Lovrencic, Marijana Vucic] Merkur Univ Hosp, Dept Lab Med, Zagreb 10000, Croatia.
   [Pibernik-Okanovic, Mirjana; Prasek, Manja; Ajdukovic, Dea; Kos, Jadranka] Merkur Univ Hosp, Vuk Vrhovac Univ Clin Diabet, Zagreb 10000, Croatia.
   [Sekerija, Mario] Croatian Inst Publ Hlth, Zagreb 10000, Croatia.
   [Hermanns, Norbert] Forschungsinst Diabet Akad Bad Mergentheim FIDAM, D-97980 Bad Mergentheim, Germany.
RP Lovrencic, MV (corresponding author), Merkur Univ Hosp, Dept Lab Med, Zajceva 19, Zagreb 10000, Croatia.
EM vucic@idb.hr
RI Sekerija, Mario/W-8550-2019; Hermanns, Norbert/AAG-7060-2020
OI Hermanns, Norbert/0000-0002-2903-2677; Vucic Lovrencic,
   Marijana/0000-0001-7365-0627
FU European Foundation for the Study of Diabetes (EFSD)-New Horizons
   Collaborative Research Initiative
FX The study was funded by the European Foundation for the Study of
   Diabetes (EFSD)-New Horizons Collaborative Research Initiative 2010. The
   authors would like to thank Lovorka Perkovic, Croatian Institute of
   Public Health, for editing the paper.
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NR 62
TC 14
Z9 15
U1 1
U2 12
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1687-8337
EI 1687-8345
J9 INT J ENDOCRINOL
JI Int. J. Endocrinol.
PY 2015
VL 2015
AR 210406
DI 10.1155/2015/210406
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA CP8MJ
UT WOS:000360147700001
PM 26347775
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Anupam, S
   Goel, S
   Bhatti, K
   Mehta, DK
   Das, R
AF Anupam, Sristi
   Goel, Simran
   Bhatti, Karun
   Mehta, Dinesh Kumar
   Das, Rina
TI Serum Gamma Glutamyl Transferase: Understanding its Contribution as a
   Potential Predictor of the Occurrence of Type 2 Diabetes
SO CURRENT DIABETES REVIEWS
LA English
DT Review
DE Gamma-glutamyl transpeptidase; glutathione; dimeric glycoprotein;
   hydrophobic; oxidative stress; metabolic syndrome
ID LIVER-ENZYMES; ALANINE AMINOTRANSFERASE; INSULIN-RESISTANCE; METABOLIC
   SYNDROME; LIFE-STYLE; MELLITUS; RISK; TRANSPEPTIDASE; ASSOCIATION;
   PREVALENCE
AB Introduction The liver and kidneys are the primary locations of the glutathione metabolism enzyme gamma-glutamyl transferase (GGT). The two main factors contributing to an increase are hepatic illnesses and excessive alcohol use. This study set out to test a theory on the predictive importance of the association between GGT and Type 2 diabetes mellitus. (T2DM).Methods In order to do this, we combed through PubMed, Google Scholar, Medline, and Science Direct for a wide range of information from previous studies. Attributes were established at the outset and compared to GGT concentration.Results GGT, present in most cells, absorbs glutathione for intracellular antioxidant defences. This study links GGT to hepatic enzymes including HDL, LDL, and triglyceride. LDL, triglycerides, AST, and ALT increased with GGT concentration, but LDL decreased. Because of obesity, GGT production rises with BMI. We found that greater GGT levels were associated with more T2DM after analysing data from multiple sources.Conclusion This literature review concludes that GGT is related to other factors such as BMI, HDL, AST, and triglycerides in the development of diabetes mellitus. Serum GGT was found to be a potential predictor of metabolic syndrome and T2DM.
C1 [Anupam, Sristi; Goel, Simran; Mehta, Dinesh Kumar; Das, Rina] Maharishi Markandeshwar Deemed Univ, MM Coll Pharm, Ambala, Haryana, India.
   [Bhatti, Karun] Maharishi Markandeshwar Deemed Univ, MM Inst Med Sci & Res, Dept Med, Ambala, Haryana, India.
C3 Maharishi Markandeshwar University; Maharishi Markandeshwar University
RP Das, R (corresponding author), Maharishi Markandeshwar Deemed Univ, MM Coll Pharm, Ambala, Haryana, India.
EM rinammu@gmail.com
RI Mehta, Dinesh Kumar/AAY-5941-2021; Das, Rina/AAX-4943-2021
OI das, rina/0000-0002-2535-2729
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NR 56
TC 3
Z9 3
U1 1
U2 3
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1573-3998
EI 1875-6417
J9 CURR DIABETES REV
JI Curr. Diabetes Reviews
PY 2025
VL 21
IS 1
AR E240124226080
DI 10.2174/0115733998260996231122054907
PG 9
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA J2X5D
UT WOS:001335747000004
PM 38275034
DA 2025-06-11
ER

PT J
AU Zhou, SY
   Zhao, K
   Shi, X
   Sun, HK
   Du, SY
   Miao, XM
   Chen, JJ
   Yang, F
   Xing, MZ
   Ran, W
   Lao, JY
   Zhang, XY
   Wang, W
   Tang, W
AF Zhou, Siyao
   Zhao, Ke
   Shi, Xiang
   Sun, Huankun
   Du, Siyu
   Miao, Xuemeng
   Chen, Jianjun
   Yang, Fan
   Xing, Minzhi
   Ran, Wang
   Lao, Jiaying
   Zhang, Xiangyang
   Wang, Wei
   Tang, Wei
TI Serum Lipid Levels and Suicide Attempts Within 2 Weeks in Patients With
   Major Depressive Disorder: Is There a Relationship?
SO FRONTIERS IN PSYCHIATRY
LA English
DT Article
DE depression; suicide unattempted; serum lipid profiles; psychotic;
   indicator
ID DRUG-NAIVE PATIENTS; CHOLESTEROL CONCENTRATION; METABOLIC SYNDROME;
   RISK-FACTOR; HDL-C; ASSOCIATION; MORTALITY; MEN; METAANALYSIS;
   1ST-EPISODE
AB The potential correlation between serum lipid profiles and suicidal tendencies has been previously reported, however, it is unclear whether serum lipid profiles have definite relevance to recently attempted suicides in individuals suffering from major depressive disorder (MDD). In this study, the relationship between blood lipids and suicide attempts in first-episode MDD patients in research were used to examine whether there is a connection. The cross-sectional study recruited 580 patients at the time of their first episode, measuring up to the diagnostic standard of MDD. Baseline demographic, clinical data, and blood lipid level data were collected. Depression severity was measured with the Hamilton Depression Rating Scale (HAMD). Our results revealed that the level of TC may be identified as a promising and effective biomarker for first-episode MDD suicide risk, suggesting that screening of serum lipid profiles in depressive patients is essential for suicide prevention.
C1 [Zhou, Siyao; Zhao, Ke; Shi, Xiang; Sun, Huankun; Du, Siyu; Miao, Xuemeng; Chen, Jianjun; Yang, Fan; Xing, Minzhi; Ran, Wang; Lao, Jiaying; Wang, Wei] Wenzhou Med Univ, Sch Mental Hlth, Wenzhou, Peoples R China.
   [Zhang, Xiangyang] Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing, Peoples R China.
   [Zhang, Xiangyang] Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China.
   [Tang, Wei] Wenzhou Med Univ, Affiliated Kangning Hosp, Wenzhou, Peoples R China.
C3 Wenzhou Medical University; Chinese Academy of Sciences; Institute of
   Psychology, CAS; Chinese Academy of Sciences; University of Chinese
   Academy of Sciences, CAS; Wenzhou Medical University
RP Wang, W (corresponding author), Wenzhou Med Univ, Sch Mental Hlth, Wenzhou, Peoples R China.; Tang, W (corresponding author), Wenzhou Med Univ, Affiliated Kangning Hosp, Wenzhou, Peoples R China.
EM wangwei@wmu.edu.cn; tangweikn@163.com
RI Lao, Jiaying/LDF-1176-2024; Wang, Wei/AID-3772-2022; Zhang,
   Xiangyang/ABC-7380-2022
OI Zhang, Xiangyang/0000-0003-3326-382X
FU Wenzhou Science and Technology Project [Y20180115]; Natural Science
   Foundation of Zhejiang Province [LQ18H090009]; medical and health
   research project of Zhejiang province [2020KY926]; Zhejiang Province
   Science and Technology Plan Research and Xinmiao Talent Program
   [2020R413073]
FX This work was supported by the Wenzhou Science and Technology Project
   (Y20180115), the Natural Science Foundation of Zhejiang Province
   (LQ18H090009), the medical and health research project of Zhejiang
   province (2020KY926), and Zhejiang Province Science and Technology Plan
   Research and Xinmiao Talent Program (2020R413073).
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NR 56
TC 13
Z9 14
U1 0
U2 12
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-0640
J9 FRONT PSYCHIATRY
JI Front. Psychiatry
PD JUN 7
PY 2021
VL 12
AR 676040
DI 10.3389/fpsyt.2021.676040
PG 8
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA SW6HG
UT WOS:000664614200001
PM 34163387
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Sundaram, SS
   Halbower, AC
   Klawitter, J
   Pan, ZX
   Robbins, K
   Capocelli, KE
   Sokol, RJ
AF Sundaram, Shikha S.
   Halbower, Ann C.
   Klawitter, Jelena
   Pan, Zhaoxing
   Robbins, Kristen
   Capocelli, Kelley E.
   Sokol, Ronald J.
TI Treating Obstructive Sleep Apnea and Chronic Intermittent Hypoxia
   Improves the Severity of Nonalcoholic Fatty Liver Disease in Children
SO JOURNAL OF PEDIATRICS
LA English
DT Article
ID POSITIVE AIRWAY PRESSURE; SERUM AMINOTRANSFERASE LEVELS;
   INSULIN-RESISTANCE; DAYTIME SLEEPINESS; LEPTIN LEVELS; CPAP;
   STEATOHEPATITIS; HEPATITIS; RISK; 15-F-2T-ISOPROSTANE
AB Objective To determine the effects of treating obstructive sleep apnea/nocturnal hypoxia on pediatric nonalcoholic fatty liver disease (NAFLD) severity and oxidative stress.
   Study design Biopsy proven participants (n = 9) with NAFLD and obstructive sleep apnea/hypoxia were studied before and after treatment with continuous positive airway pressure (CPAP) for sleep disordered breathing, including laboratory testing and markers of oxidative stress, urine F(2)-isoprostanes.
   Results Adolescents (age 11.5 +/- 1.2 years; body mass index, 29.5 +/- 3.8 kg/m(2)) with significant NAFLD (mean histologic necroinflammation grade, 2.3 +/- 0.9; fibrosis stage, 1.4 +/- 1.3; NAFLD Activity Score summary, 4.8 +/- 1.6) had obstructive sleep apnea/hypoxia by polysomnography. At baseline, they had severe obstructive sleep apnea/hypoxia, elevated aminotransferases, the metabolic syndrome, and significant oxidative stress (high F(2)-isoprostanes). Obstructive sleep apnea/hypoxia was treated with home CPAP for a mean 89 +/- 62 days. Although body mass index increased, obstructive sleep apnea/hypoxia severity improved on CPAP and was accompanied by reduced alanine aminotransferase, metabolic syndrome markers. and F(2)-isoprostanes.
   Conclusions This study provides strong evidence that treatment of obstructive sleep apnea/nocturnal hypoxia with CPAP in children with NAFLD may reverse parameters of liver injury and reduce oxidative stress. These data also suggest CPAP as a new therapy to prevent progression of NAFLD in those children with obesity found to have obstructive sleep apnea/nocturnal hypoxia.
C1 [Sundaram, Shikha S.; Robbins, Kristen; Sokol, Ronald J.] Childrens Hosp Colorado, Sect Gastroenterol Hepatol & Nutr, Dept Pediat, Aurora, CO USA.
   [Sundaram, Shikha S.; Robbins, Kristen; Sokol, Ronald J.] Childrens Hosp Colorado, Digest Hlth Inst, 13123 E 16th Ave,B290, Aurora, CO 80045 USA.
   [Sundaram, Shikha S.; Robbins, Kristen; Sokol, Ronald J.] Univ Colorado, Sch Med, Aurora, CO USA.
   [Halbower, Ann C.] Childrens Hosp Colorado, Sect Pulm Med, Dept Pediat, Aurora, CO USA.
   [Halbower, Ann C.; Pan, Zhaoxing] Univ Colorado, Sch Med, Anschutz Med Ctr, Aurora, CO USA.
   [Klawitter, Jelena] Univ Colorado, Clin Res & Dev IC42, Dept Anesthesiol, Sch Med, Aurora, CO USA.
   [Pan, Zhaoxing] Childrens Hosp Colorado, Biostat Core Res Inst, Aurora, CO USA.
   [Capocelli, Kelley E.] Univ Colorado, Pediat Pathol, Dept Pathol, Sch Med, Aurora, CO USA.
C3 Children's Hospital Colorado; Children's Hospital Colorado; University
   of Colorado System; University of Colorado Anschutz Medical Campus;
   Children's Hospital Colorado; University of Colorado System; University
   of Colorado Anschutz Medical Campus; University of Colorado System;
   University of Colorado Anschutz Medical Campus; Children's Hospital
   Colorado; University of Colorado System; University of Colorado Anschutz
   Medical Campus
RP Sundaram, SS (corresponding author), Childrens Hosp Colorado, Digest Hlth Inst, 13123 E 16th Ave,B290, Aurora, CO 80045 USA.
EM shikha.sundaram@childrenscolorado.org
OI Sokol, Ronald/0000-0001-7433-4095
FU National Institutes of Health (NIH) [K23 DK085150]; NIH/NCATS Colorado
   CTSA [UL1TR001082]
FX Supported by the National Institutes of Health (NIH, K23 DK085150) and
   NIH/NCATS Colorado CTSA (UL1TR001082). Its contents are the authors'
   sole responsibility and do not necessarily represent official NIH views.
   The authors declare no conflicts of interest.
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NR 60
TC 40
Z9 40
U1 1
U2 7
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0022-3476
EI 1097-6833
J9 J PEDIATR-US
JI J. Pediatr.
PD JUL
PY 2018
VL 198
BP 67
EP +
DI 10.1016/j.jpeds.2018.03.028
PG 10
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA GL0XL
UT WOS:000436817000015
PM 29752170
DA 2025-06-11
ER

PT J
AU Kelly, AS
   Jacobs, DR
   Sinaiko, AR
   Moran, A
   Steffen, LM
   Steinberger, J
AF Kelly, Aaron S.
   Jacobs, David R., Jr.
   Sinaiko, Alan R.
   Moran, Antoinette
   Steffen, Lyn M.
   Steinberger, Julia
TI Relation of circulating oxidized LDL to obesity and insulin resistance
   in children
SO PEDIATRIC DIABETES
LA English
DT Article
DE children; insulin resistance; obesity; oxidized LDL
ID LOW-DENSITY-LIPOPROTEIN; CORONARY-ARTERY-DISEASE; METABOLIC SYNDROME;
   OXIDATIVE STRESS; RISK-FACTORS; ADULTS; DETERMINANTS; MARKERS; WOMEN;
   CLAMP
AB Introduction: Circulating oxidized low-density lipoprotein (LDL), a marker of oxidative stress, is associated with obesity, insulin resistance, metabolic syndrome, and cardiovascular disease in adults. However, little is known about its relation to insulin resistance and cardiovascular risk factors in children. The purpose of this study was to assess the relation of oxidative stress, measured by circulating oxidized LDL, with measures of adiposity and insulin resistance in children.
   Methods: Oxidized LDL, measures of body fatness (body mass index: BMI, percent body fat, waist circumference, percent trunk fat, abdominal visceral and subcutaneous fat), insulin resistance with euglycemic insulin clamp (Mlbm), blood pressure, and blood lipids were obtained in 78 children. Oxidized LDL was compared between normal weight children (BMI < 85th percentile) and overweight/obese children (BMI >= 85th percentile) and levels were evaluated for associations with body fatness and insulin resistance.
   Results: Oxidized LDL levels were significantly higher in overweight/obese vs. normal weight children (p < 0.0001). Oxidized LDL was significantly correlated with BMI, percent body fat, waist circumference, percent trunk fat, abdominal visceral fat, and abdominal subcutaneous fat (all p-values < 0.0001). Moreover, oxidized LDL was negatively correlated with Mlbm, even after adjustment for adiposity (p < 0.01).
   Conclusions: Oxidized LDL is significantly associated with adiposity and with insulin resistance, independent of body fatness, in children. Oxidative stress may be independently related to the development of insulin resistance early in life, especially in obese youth.
C1 [Kelly, Aaron S.] Univ Minnesota, Sch Med, Div Epidemiol & Clin Res, Dept Pediat, Minneapolis, MN 55455 USA.
   [Jacobs, David R., Jr.; Steffen, Lyn M.] Univ Minnesota, Sch Publ Hlth, Div Epidemiol, Minneapolis, MN 55455 USA.
   [Jacobs, David R., Jr.] Univ Oslo, Dept Nutr, Oslo, Norway.
C3 University of Minnesota System; University of Minnesota Twin Cities;
   University of Minnesota System; University of Minnesota Twin Cities;
   University of Oslo
RP Kelly, AS (corresponding author), Univ Minnesota, Sch Med, Div Epidemiol & Clin Res, Dept Pediat, 420 Delaware St SE,MMC 715, Minneapolis, MN 55455 USA.
EM kelly105@umn.edu
RI Jacobs, David/G-5405-2011
OI Steinberger, Julia/0000-0002-2892-8594; Jacobs,
   David/0000-0002-7232-0543; Steffen, Lyn M/0000-0002-4053-6729
FU University of Minnesota Vikings Children's; National Institutes of
   Health [1RO1DK072124-01A3]; NCRR/NIH [GCRC: M01-RR00400]
FX Funding for this study was provided by the University of Minnesota
   Vikings Children's Fund (A.S.K.), National Institutes of Health:
   1RO1DK072124-01A3 (J.S.), and GCRC: M01-RR00400, General Clinical
   Research Center Program, NCRR/NIH. Mercodia Inc. generously donated the
   competitive ELISA kits for oxidized LDL analysis.
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NR 19
TC 60
Z9 66
U1 0
U2 8
PU WILEY-BLACKWELL PUBLISHING, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1399-543X
J9 PEDIATR DIABETES
JI Pediatr. Diabetes
PD DEC
PY 2010
VL 11
IS 8
BP 552
EP 555
DI 10.1111/j.1399-5448.2009.00640.x
PG 4
WC Endocrinology & Metabolism; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Pediatrics
GA 688NA
UT WOS:000284854900007
PM 20102528
OA gold, Green Accepted
DA 2025-06-11
ER

PT J
AU Razani, B
   Feng, C
   Semenkovich, CF
AF Razani, Babak
   Feng, Chu
   Semenkovich, Clay F.
TI p53 is required for chloroquine-induced atheroprotection but not insulin
   sensitization
SO JOURNAL OF LIPID RESEARCH
LA English
DT Article
DE atherosclerosis; insulin resistance; type 2 diabetes mellitus; genotoxic
   stress response; metabolic syndrome
ID SMOOTH-MUSCLE-CELLS; ATAXIA-TELANGIECTASIA; DNA-DAMAGE;
   CARDIOVASCULAR-DISEASE; SIGNALING PATHWAYS; METABOLIC SYNDROME;
   PIFITHRIN-ALPHA; PTEN EXPRESSION; CRUCIAL ROLE; ATHEROSCLEROSIS
AB An intact genotoxic stress response appears to be atheroprotective and insulin sensitizing. ATM, mutated in ataxia telangiectasia, is critical for the genotoxic stress response, and its deficiency is associated with accelerated atherosclerosis and insulin resistance in humans and mice. The antimalarial drug chloroquine activates ATM signaling and improves metabolic phenotypes in mice. p53 is a major effector of ATM signaling, but it is unknown if p53 is required for the beneficial effects of chloroquine. We tested the hypothesis that the cardiometabolic effects of chloroquine are p53-dependent. ApoE-null mice with or without p53 were treated with low-dose chloroquine or saline in the setting of a Western diet. After 8 weeks, there was no p53-dependent or chloroquine-specific effect on serum lipids or body weight. Chloroquine reduced plaque burden in mice wild-type for p53, but it did not decrease lesion extent in p53-null mice. However, chloroquine improved glucose tolerance, enhanced insulin sensitivity, and increased hepatic Akt signaling regardless of the p53 genotype. These results indicate that atheroprotection induced by chloroquine is p53-dependent but the insulin-sensitizing effects of this agent are not. Discrete components of the genotoxic stress response might be targeted to treat lipid- driven disorders, such as diabetes and atherosclerosis.-Razani, B., C. Feng, and C. F. Semenkovich. p53 is required for chloroquine-induced atheroprotection but not insulin sensitization. J. Lipid Res. 2010. 51: 1738-1746.
C1 [Razani, Babak; Feng, Chu; Semenkovich, Clay F.] Washington Univ, Sch Med, Dept Med, St Louis, MO 63110 USA.
   [Semenkovich, Clay F.] Washington Univ, Sch Med, Dept Cell Biol & Physiol, St Louis, MO 63110 USA.
C3 Washington University (WUSTL); Washington University (WUSTL)
RP Semenkovich, CF (corresponding author), Washington Univ, Sch Med, Dept Med, St Louis, MO 63110 USA.
EM csemenko@wustl.edu
RI Segura-Aguilar, Juan/H-8839-2013
OI Razani, Babak/0000-0002-7172-9240; Semenkovich, Clay/0000-0003-1163-1871
FU National Institutes of Health (Clinical Nutrition Research Unit,
   Washington University) [P50-HL-083762, DK-076729, DK-56341]; National
   Institutes of Health (Diabetes Research and Training Center, Washington
   University) [DK-20579]; Physician Scientist Training Program and
   Cardiovascular Training Grant at Washington University
FX This work was supported by National Institutes of Health Grants
   P50-HL-083762, DK-076729, DK-56341 (Clinical Nutrition Research Unit,
   Washington University) and DK-20579 (Diabetes Research and Training
   Center, Washington University); and by the Physician Scientist Training
   Program and Cardiovascular Training Grant at Washington University. Its
   contents are solely the responsibility of the authors and do not
   necessarily represent the official views of the National Institutes of
   Health or other granting agencies.
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NR 45
TC 26
Z9 26
U1 1
U2 3
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0022-2275
EI 1539-7262
J9 J LIPID RES
JI J. Lipid Res.
PD JUL
PY 2010
VL 51
IS 7
BP 1738
EP 1746
DI 10.1194/jlr.M003681
PG 9
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 609BB
UT WOS:000278628700010
PM 20208057
OA Green Published
DA 2025-06-11
ER

PT J
AU Kyalwazi, AN
   Woods-Giscombe, CL
   Johnson, MP
   Jones, C
   Hayes, SN
   Cooper, LA
   Patten, CA
   Brewer, LC
AF Kyalwazi, Ashley N.
   Woods-Giscombe, Cheryl L.
   Johnson, Matthew P.
   Jones, Clarence
   Hayes, Sharonne N.
   Cooper, Lisa A.
   Patten, Christi A.
   Brewer, LaPrincess C.
TI Associations Between the Superwoman Schema, Stress, and Cardiovascular
   Health Among African-American Women
SO ANNALS OF BEHAVIORAL MEDICINE
LA English
DT Article
DE African Americans; Women's health; Stress; Cardiovascular risk factors
ID RISK
AB Background African-American (AA) women are less likely to achieve ideal cardiovascular (CV) health compared with women of other racial/ethnic subgroups, primarily due to structural and psychosocial barriers. A potential psychosocial construct relevant to ideal CV health is the superwoman schema (SWS).Purpose We explored whether the SWS was associated with perceived stress, CV risk factors, and overall CV health among AA women.Methods This cross-sectional analysis of the FAITH! Heart Health+ Study was conducted among AA women with high cardiometabolic risk. Pearson correlation evaluated associations between SWS and CV risk factors (e.g., stress, hypertension, diabetes, etc.). The 35-item SWS questionnaire includes five domains. Stress was measured by the 8-item Global Perceived Stress Scale (GPSS). CV health was assessed using the American Heart Association Life's Simple 7 (LS7) rubric of health behaviors/biometrics. Data acquisition spanned from February to August 2022.Results The 38 women included in the analysis (mean age 54.3 [SD 11.5] years) had a high CV risk factor burden (71.1% hypertension, 76.3% overweight/obesity, 28.9% diabetes, 39.5% hyperlipidemia). Mean GPSS level was 7.7 (SD 5.2), CV health score 6.7 (SD 1.8), and SWS score 60.3 (SD 18.0). Feeling an "obligation to help others" and "obligation to present an image of strength" had strongest correlations with GPSS score among all SWS domains (r = 0.51; p = .002 and r = 0.39; p = .02, respectively). Correlation among the SWS domains and traditional CV risk factors was not statistically significant.Conclusion Our findings suggest that an obligation to help others and to project an image of strength could be contributing to stress among AA women.
   Compared with women of other racial groups, African-American (AA) women in the USA have a higher cardiovascular (CV) disease burden and are at higher risk of maternal mortality from preventable CV health outcomes. The Giscombe Superwoman Schema (SWS) is a framework designed to characterize various aspects of the superwoman role that AA women may adopt to preserve themselves, their families, and their communities amidst the myriad of inequities that can compromise their ability to achieve ideal CV health. In this Brief Report, our team explored whether the SWS was associated with perceived stress, CV risk factors, and overall CV health among AA women. The study participants were AA women with high cardiometabolic risk residing in the Rochester and Minneapolis, St. Paul, Minnesota areas, recruited from the FAITH! Heart Health+ Study. We observed a positive association between the SWS and perceived stress levels, suggesting that the obligation to help others and to project an image of strength could be contributing to overall stress levels among AA women.
C1 [Kyalwazi, Ashley N.] Harvard Med Sch, Boston, MA 02115 USA.
   [Woods-Giscombe, Cheryl L.] Univ North Carolina Chapel Hill, Sch Nursing, Chapel Hill, NC USA.
   [Johnson, Matthew P.] Mayo Clin, Dept Quantitat Hlth Sci, Div Clin Trials & Biostat, Rochester, MN USA.
   [Jones, Clarence] Hue Man Partnership, Minneapolis, MN USA.
   [Hayes, Sharonne N.; Brewer, LaPrincess C.] Mayo Clin, Coll Med, Dept Cardiovasc Med, Rochester, MN USA.
   [Cooper, Lisa A.] Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD USA.
   [Patten, Christi A.] Mayo Clin, Coll Med, Dept Psychiat & Psychol, Rochester, MN USA.
   [Brewer, LaPrincess C.] Mayo Clin, Ctr Hlth Equ & Community Engagement Res, Rochester, MN USA.
C3 Harvard University; Harvard Medical School; University of North
   Carolina; University of North Carolina Chapel Hill; University of North
   Carolina School of Medicine; Mayo Clinic; Mayo Clinic; Johns Hopkins
   University; Mayo Clinic; Mayo Clinic
RP Kyalwazi, AN (corresponding author), Harvard Med Sch, Boston, MA 02115 USA.
EM ashley_kyalwazi@hms.harvard.edu; cherylw@email.unc.edu;
   johnson.matthew5@mayo.edu; clarencejones7428@gmail.com;
   hayes.sharonne@mayo.edu; lisa.cooper@jhmi.edu; patten.christi@mayo.edu;
   brewer.laprincess@mayo.edu
RI GISCOMBE, CHERYL/AAG-5815-2020
OI Woods-Giscombe, Cheryl/0000-0001-6245-783X; Cooper,
   Lisa/0000-0001-6707-6390; jones, clarence/0000-0001-9030-2368; Hayes,
   Sharonne/0000-0003-3129-362X; Brewer, LaPrincess/0000-0002-6468-9324
FU National Institutes of Health (NIH)/National Institute on Minority
   Health and Health Disparities (NIMHD) [1 R21 MD013490-01]; National
   Center for Advancing Translational Sciences (NCATS) [UL1 TR000135]; Mayo
   Clinic Center for Health Equity and Community Engagement in Research;
   Mayo Clinic Executive Office; American Heart Association-Amos Medical
   Faculty Development Program [19AMFDP35040005]; NCATS (CTSA) [KL2
   TR002379]; Centers for Disease Control and Prevention (CDC)
   [CDC-DP18-1817]; NIMHD [5R01MD015388]; National Center for Complementary
   and Integrative Health [5T32AT003378]
FX Preliminary findings of this study were presented as an abstract at the
   2023 Society of Behavioral Medicine Annual Meeting and Scientific
   Sessions in Phoenix, Arizona (Cardiovascular Disease Special Interest
   Group Trainee Award). We extend our gratitude to the FAITH! Community
   Steering Committee members, including Courtney Baechler, MD, Allyson
   Brotherson, MD, Tawonda Burks, Wale Elegbede, Princess Titus, Jacqueline
   Johnson, Loralean Jordan, Sandra Means, Stanton Shanedling, PhD, Sueling
   Schardin, Samuel Simmons, and Pastor Johnnie B. Williams, for their
   valuable input and support of this study. We also appreciate all study
   participants for their commitment to diversity in research and clinical
   trials. The research reported herein was supported by the National
   Institutes of Health (NIH)/National Institute on Minority Health and
   Health Disparities (NIMHD) (grant 1 R21 MD013490-01), the Clinical and
   Translational Science Awards (CTSA) (grant UL1 TR000135) from the
   National Center for Advancing Translational Sciences (NCATS) to Mayo
   Clinic, the Mayo Clinic Center for Health Equity and Community
   Engagement in Research and the Mayo Clinic Executive Office. Dr. Brewer
   was supported by the American Heart Association-Amos Medical Faculty
   Development Program (grant 19AMFDP35040005), NCATS (CTSA grant KL2
   TR002379) and the Centers for Disease Control and Prevention (CDC, grant
   CDC-DP18-1817) during the implementation of this work. Dr.
   Woods-Giscombe was supported by the NIMHD (grant 5R01MD015388) and the
   National Center for Complementary and Integrative Health (grant
   5T32AT003378). Its contents are solely the responsibility of the authors
   and do not necessarily represent the official views of NCATS, NIH, or
   CDC. The funding bodies had no role in the study design; in the
   collection, analysis, and interpretation of data; writing of the
   manuscript; and in the decision to submit the manuscript for
   publication.
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NR 20
TC 1
Z9 1
U1 0
U2 2
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0883-6612
EI 1532-4796
J9 ANN BEHAV MED
JI Ann. Behav. Med.
PD AUG 31
PY 2024
VL 58
IS 12
BP 863
EP 868
DI 10.1093/abm/kaae047
EA AUG 2024
PG 6
WC Psychology, Multidisciplinary
WE Social Science Citation Index (SSCI)
SC Psychology
GA M1Y4G
UT WOS:001303492000001
PM 39216076
DA 2025-06-11
ER

PT J
AU Kobori, M
   Masumoto, S
   Akimoto, Y
   Oike, H
AF Kobori, Masuko
   Masumoto, Saeko
   Akimoto, Yukari
   Oike, Hideaki
TI Chronic dietary intake of quercetin alleviates hepatic fat accumulation
   associated with consumption of a Western-style diet in C57/BL6J mice
SO MOLECULAR NUTRITION & FOOD RESEARCH
LA English
DT Article
DE Liver steatosis; Metabolic disorder; Oxidative stress; Quercetin;
   Western diet
ID ACTIVATED PROTEIN-KINASE; OXIDATIVE STRESS; INSULIN-RESISTANCE;
   CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; GENE-EXPRESSION; IN-VIVO;
   LIVER; OBESITY; STEATOSIS
AB Scope: To determine the effect of consumption of a quercetin-rich diet on obesity and dysregulated hepatic gene expression.
   Methods and results: C56BL/6J mice were fed for 20wk on AIN93G (control) or a Western diet high in fat, cholesterol and sucrose, both with or without 0.05% quercetin. Triglyceride levels in plasma, thiobarbituric acid-reactive substances (oxidative stress marker) and glutathione levels and peroxisome proliferator-activated receptor alpha expression in livers of mice fed with the Western diet were all improved after 8wk feeding with quercetin. After 20 wk, further reductions of visceral and liver fat accumulation and improved hyperglycemia, hyperinsulinemia, dyslipidemia and plasma adiponectin and TNF alpha levels in these mice fed with quercetin were observed. The expression of hepatic genes related to steatosis, such as peroxisome proliferator-activated receptor gamma and sterol regulatory element-binding protein-1c was also normalized by quercetin. In mice fed with the control diet, quercetin did not affect body weight but reduces the plasma TNF alpha and hepatic thiobarbituric acid-reactive substance levels.
   Conclusion: In mice fed with a Western diet, chronic dietary intake of quercetin reduces liver fat accumulation and improves systemic parameters related to metabolic syndrome, probably mainly through decreasing oxidative stress and reducing PPAR alpha expression, and the subsequent reduced expression in the liver of genes related to steatosis.
C1 [Kobori, Masuko; Masumoto, Saeko; Akimoto, Yukari; Oike, Hideaki] Natl Agr & Food Res Org, Natl Food Res Inst, Tsukuba, Ibaraki 3058642, Japan.
C3 National Food Research Institute - Japan; National Agriculture & Food
   Research Organization - Japan
RP Kobori, M (corresponding author), Natl Agr & Food Res Org, Natl Food Res Inst, 2-1-12 Kannondai, Tsukuba, Ibaraki 3058642, Japan.
EM kobori@affrc.go.jp
RI Oike, Hideaki/C-6457-2009
OI Masumoto, Saeko/0000-0003-3174-9738; Oike, Hideaki/0000-0002-6139-5726
FU Ministry of Agriculture, Forestry and Fisheries (MAFF)
FX This work was supported in part by a grant from the Ministry of
   Agriculture, Forestry and Fisheries (MAFF) Food Research Project
   'Development of evaluation and management methods for supply of reliable
   and functional food and farm produce'.
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NR 50
TC 202
Z9 224
U1 0
U2 61
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1613-4125
EI 1613-4133
J9 MOL NUTR FOOD RES
JI Mol. Nutr. Food Res.
PD APR
PY 2011
VL 55
IS 4
BP 530
EP 540
DI 10.1002/mnfr.201000392
PG 11
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA 748TV
UT WOS:000289416100003
PM 21462320
DA 2025-06-11
ER

PT J
AU Feillet-Coudray, C
   Fouret, G
   Vigor, C
   Bonafos, B
   Jover, B
   Blachnio-Zabielska, A
   Rieusset, J
   Casas, F
   Gaillet, S
   Landrier, JF
   Durand, T
   Coudray, C
AF Feillet-Coudray, Christine
   Fouret, Gilles
   Vigor, Claire
   Bonafos, Beatrice
   Jover, Bernard
   Blachnio-Zabielska, Agnieszka
   Rieusset, Jennifer
   Casas, Francois
   Gaillet, Sylvie
   Landrier, Jean Francois
   Durand, Thierry
   Coudray, Charles
TI Long-Term Measures of Dyslipidemia, Inflammation, and Oxidative Stress
   in Rats Fed a High-Fat/High-Fructose Diet
SO LIPIDS
LA English
DT Article
DE Glucose intolerance; Hepatic steatosis; High-fat diet; Inflammation;
   Isoprostanoids; Lipids; Metabolic syndrome; Obesity; Oxidative stress;
   Rat
ID HIGH-FAT DIET; METABOLIC SYNDROME; LIVER-DISEASE; INSULIN-RESISTANCE;
   ADIPOSE-TISSUE; NADPH OXIDASES; NOX FAMILY; OBESITY; ASSAY; ISOPROSTANES
AB Inflammation and oxidative stress are thought to be involved in, or associated with, the development of obesity, dyslipidemia, hepatic steatosis, and insulin resistance. This work was designed to determine the evolution of inflammation and oxidative stress during onset and progression of hepatic steatosis and glucose intolerance. Seventy-five male Wistar rats were divided to control and high-fat high-fructose (HFHFr) groups. A subgroup of each group was sacrificed at 4, 8, 12, 16, and 20 weeks. HFHFr-fed rats exhibited overweight, glucose intolerance, and hepatic steatosis with increased contents of hepatic diacylglycerols and ceramides. The HFHFr diet increased hepatic interleukin 6 (IL-6) protein and adipose tissue CCL5 gene expression and hepatic nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity but not mitochondrial reactive oxygen species (ROS) production. The HFHFr diet decreased plasma and liver levels of isoprostanoid metabolites as well as plasma thiobarbituric acid-reactive substance (TBARS) levels. Hepatic glutathione content was decreased with a moderate decrease in superoxide dismutase (SOD) and glutathione peroxidase (GPx) with the HFHFr diet. Overall, HFHFr diet led to hepatic lipid accumulation and glucose intolerance, which were accompanied by only moderate inflammation and oxidative stress. Most of these changes occurred at the same time and as early as 8 or 12 weeks of diet treatment. This implies that oxidative stress may be the result, not the cause, of these metabolic alterations, and suggests that marked hepatic oxidative stress should probably occur at the end of the steatotic stage to result in frank insulin resistance and steatohepatitis. These findings need to be further evaluated in other animal species as well as in human studies.
C1 [Feillet-Coudray, Christine; Fouret, Gilles; Bonafos, Beatrice; Casas, Francois; Gaillet, Sylvie; Coudray, Charles] Univ Montpellier, INRA, DMEM Dynam Musculaire & Metab, 2 Pl Viala, F-34060 Montpellier, France.
   [Vigor, Claire; Durand, Thierry] Univ Montpellier, IBMM, CNRS, ENSCM, 15 Ave Charles Flahault, F-34090 Montpellier, France.
   [Jover, Bernard] Univ Montpellier, INSERM, CNRS, PhyMedExp, 371 Ave Doyen Gaston Giraud, F-34295 Montpellier, France.
   [Blachnio-Zabielska, Agnieszka] Med Univ Bialystok, Dept Physiol, Jana Kilinskiego 1, PL-15089 Bialystok, Poland.
   [Blachnio-Zabielska, Agnieszka] Med Univ Bialystok, Epidemiol & Metab Disorders Dept, Jana Kilinskiego 1, PL-15089 Bialystok, Poland.
   [Rieusset, Jennifer] Fac Med Lyon Sud, INSERM, UMR U1060, 165 Chemin Grand Revoyet, F-69921 Oullins, France.
   [Landrier, Jean Francois] Aix Marseille Univ, INSERM, INRA, C2VN, 27 Blvd Jean Moulin, F-13385 Marseille, France.
C3 Universite de Montpellier; INRAE; Ecole nationale superieure de chimie
   de Montpellier; Centre National de la Recherche Scientifique (CNRS);
   Universite de Montpellier; Institut National de la Sante et de la
   Recherche Medicale (Inserm); Universite de Montpellier; Centre National
   de la Recherche Scientifique (CNRS); Medical University of Bialystok;
   Medical University of Bialystok; Universite Claude Bernard Lyon 1;
   Institut National de la Sante et de la Recherche Medicale (Inserm);
   Aix-Marseille Universite; Institut National de la Sante et de la
   Recherche Medicale (Inserm); INRAE
RP Coudray, C (corresponding author), Univ Montpellier, INRA, DMEM Dynam Musculaire & Metab, 2 Pl Viala, F-34060 Montpellier, France.
EM charles.coudray@inra.fr
RI COUDRAY, Charles/AGG-4757-2022; Blachnio-Zabielsk,
   Agnieszka/A-4879-2018; Rieusset, Jennifer/F-1595-2018; Landrier,
   Jean-Francois/AAH-2757-2019
OI Lab, Carmen/0000-0002-5935-3236; JOVER, Bernard/0000-0001-5826-5755;
   Rieusset, Jennifer/0000-0002-1587-2253; VIGOR,
   Claire/0000-0002-1569-0425; Carmen, Team2/0000-0001-9867-5724; Landrier,
   Jean-Francois/0000-0002-8690-8014; Blachnio-Zabielska,
   Agnieszka/0000-0002-8055-0576; Francois, Casas/0000-0002-5535-8195
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NR 52
TC 40
Z9 44
U1 2
U2 21
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0024-4201
EI 1558-9307
J9 LIPIDS
JI Lipids
PD JAN
PY 2019
VL 54
IS 1
BP 81
EP 97
DI 10.1002/lipd.12128
PG 17
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA HL7ZT
UT WOS:000458961300009
PM 30767221
OA Green Published
DA 2025-06-11
ER

PT J
AU Sankhla, M
   Sharma, TK
   Mathur, K
   Rathor, JS
   Butolia, V
   Gadhok, AK
   Vardey, SK
   Sinha, M
   Kaushik, GG
AF Sankhla, Manisha
   Sharma, Tarun Kumar
   Mathur, Keerti
   Rathor, Jai Singh
   Butolia, Varsha
   Gadhok, Amita K.
   Vardey, Satish Kumar
   Sinha, Maheep
   Kaushik, G. G.
TI Relationship of Oxidative Stress with Obesity and its Role in Obesity
   Induced Metabolic Syndrome
SO CLINICAL LABORATORY
LA English
DT Article
DE Obesity; abdominal adiposity; oxidative stress; adiponectin
ID DENSITY-LIPOPROTEIN CHOLESTEROL; ADIPONECTIN; INFLAMMATION; GLUCOSE;
   PLASMA; RISK; MEN
AB Background: Individuals with obesity and abdominal adiposity are at higher risk for hypeinsulinaemia, insulin resistance, and diabetes. This study was therefore designed to investigate the relationship of obesity with oxidative stress and the role of abdominal adiposity on obesity induced oxidative stress, and further to explore the possible mechanism of obesity associated metabolic syndrome.
   Methods: A total of 150 subjects (120 men and 30 women), aged 17-26 years of both genders, were studied. Body Mass Index and Waist-to-Hip Ratio were taken as a measure of generalized obesity and abdominal adiposity. The biochemical tests done included fasting blood glucose (FBG), lipid profile parameters, serum malondialdehyde (as a biomarker of oxidative stress), and serum adiponectin.
   Results: The concentration of serum malondialdehyde (MDA) increased with increasing levels of BMI (as per the NW classification), which was found to be non-significant statistically in overweight subjects while obese class-I and class-II subjects exhibited a statistically significant (p<0.001) higher level of serum malondialdehyde as compared to normal-weight subjects. Furthermore, according to the present study groups, on comparison with normal-weight subjects (Group-I), obese subjects with abdominal adiposity (Class-2) had statistically significant (p<0.001) higher serum concentration of malondialdehyde while a non-significant difference was observed in obese subjects without abdominal adiposity (Class-1). Even within the subset of obese subjects, a statistically significant (p<0.001) difference was depicted, suggesting the role of abdominal adiposity. Karl Pearson coefficient of correlation revealed a statistically significant negative correlation of malondialdehyde with adiponectin (r = - 0.587; p<0.001).
   Conclusions: Obese subjects exhibit increased systemic oxidative stress, which is enhanced when obesity is associated with abdominal adiposity and, moreover, increased oxidative stress is associated with adiponectin deficiency. (Clin. Lab. 2012;58:385-392)
C1 [Sharma, Tarun Kumar] Univ Hlth Sci, Dept Biochem, Pt BD Sharma, PGIMS, Rohtak 124001, Haryana, India.
   [Sankhla, Manisha; Mathur, Keerti] SMS Med Coll & Hosp, Dept Physiol, Jaipur, Rajasthan, India.
   [Rathor, Jai Singh] Fortis Escorts Hosp, Jaipur, Rajasthan, India.
   [Butolia, Varsha] Jhalawar Med Coll, Dept Physiol, Jhalawar, Rajasthan, India.
   [Gadhok, Amita K.] Rama Med Coll & Hosp, Dept Biochem, Ghaziabad, UP, India.
   [Vardey, Satish Kumar; Sinha, Maheep] SMS Med Coll & Hosp, Dept Biochem, Jaipur, Rajasthan, India.
   [Kaushik, G. G.] JLN Med Coll, Dept Biochem, Ajmer, Rajasthan, India.
C3 Pt. B.D. Sharma Post Graduate Institute of Medical Sciences (PGIMS),
   Rohtak; SMS Medical College & Hospital; Fortis Escorts Hospital; Rama
   University; SMS Medical College & Hospital
RP Sharma, TK (corresponding author), Univ Hlth Sci, Dept Biochem, Pt BD Sharma, PGIMS, Rohtak 124001, Haryana, India.
EM sharma_bio82@yahoo.co.in
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NR 32
TC 107
Z9 116
U1 0
U2 8
PU CLIN LAB PUBL
PI HEIDELBERG
PA IM BREITSPIEL 15, HEIDELBERG, D-69126, GERMANY
SN 1433-6510
J9 CLIN LAB
JI Clin. Lab.
PY 2012
VL 58
IS 5-6
BP 385
EP 392
PG 8
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA 964QF
UT WOS:000305711100002
PM 22783566
DA 2025-06-11
ER

PT J
AU Kim, YH
   Kim, SM
   Kim, JJ
   Cho, IS
   Jeon, MJ
AF Kim, Yun Hwan
   Kim, Sun Mie
   Kim, Jin Ju
   Cho, In Seong
   Jeon, Myung Jae
TI Does Metabolic Syndrome Impair Sexual Function in Middle- to Old-Aged
   Women?
SO JOURNAL OF SEXUAL MEDICINE
LA English
DT Article
DE Metabolic Syndrome; Female Sexual Function; FSFI
ID INDEX FSFI; DYSFUNCTION; PREVALENCE; KOREA
AB Introduction.
   To date, there are few studies dealing with the impact of metabolic syndrome (MS) on female sexual function, and the association between MS and female sexual dysfunction (FSD) in middle- to old-aged women remains unclear.
   Aim.
   To evaluate the impact of MS on sexual function in middle- to old-aged women.
   Methods.
   From May 2009 to January 2010, we performed a cross-sectional study of sexually active women (>= 40 years old) who visited a health-screening clinic. Comprehensive history taking, anthropometric measurement, laboratory testing, and questionnaire administration were performed for each of the total 773 women enrolled.
   Main Outcome Measures.
   The Female Sexual Function Index (FSFI) was used to assess the key dimensions of female sexual function.
   Results.
   The median age of enrolled subjects was 48 (40-65) years, and the rates of MS and FSD were 12.2% (94/773) and 54.7% (423/773), respectively. We found that the demographics of women with and without MS (P < 0.05) differed significantly from one another in terms of age, menopausal status, body mass index, educational status, household income, and urinary incontinence (UI) symptoms, although their frequency of FSD was similar (52.1% vs. 55.1%). After adjusting clinical confounders, we found that only the pain domain score was significantly different between women with MS and without MS, while the total FSFI score and other constituent domain scores showed little difference between the two groups. However, in the multivariate logistic regression model, MS and most of its components were not associated with FSD; only age, menopausal status, smoking, depression, and symptomatic UI proved to be independent risk factors for FSD (P < 0.05).
   Conclusions.
   Our study suggests that MS may have little impact on sexual function in middle- to old-aged women. Further studies with population-based and longitudinal design should be conducted to confirm this finding. Kim YH, Kim SM, Kim JJ, Cho IS, and Jeon MJ. Does metabolic syndrome impair sexual function in middle- to old-aged women? J Sex Med 2011;8:1123-1130.
C1 [Jeon, Myung Jae] Seoul Natl Univ, Coll Med, Dept Obstet & Gynecol, Seoul 110744, South Korea.
   [Kim, Yun Hwan] Ewha Womans Univ, Dept Obstet & Gynecol, Sch Med, Seoul, South Korea.
   [Kim, Yun Hwan] Ewha Womans Univ, Med Res Inst, Sch Med, Seoul, South Korea.
   [Kim, Sun Mie; Kim, Jin Ju] Seoul Natl Univ Hosp Hlth Care Syst, Dept Obstet & Gynecol, GangNam Ctr, Seoul, South Korea.
   [Cho, In Seong] Seoul Natl Univ, Coll Med, Dept Prevent Med, Seoul 110744, South Korea.
C3 Seoul National University (SNU); Ewha Womans University; Ewha Womans
   University; Seoul National University (SNU); Seoul National University
   Hospital; Seoul National University (SNU)
RP Jeon, MJ (corresponding author), Seoul Natl Univ, Coll Med, Dept Obstet & Gynecol, 28 Yongon Dong, Seoul 110744, South Korea.
EM jeonmj@snu.ac.kr
RI Jeon, Myung/O-2486-2019; Kim, Jin/C-4294-2013; Kim, Kwang
   Pyo/AAG-1815-2020
OI Kim, Yun Hwan/0000-0001-9498-2938; Jeon, Myung Jae/0000-0001-5582-1488
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NR 30
TC 31
Z9 34
U1 0
U2 3
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1743-6095
EI 1743-6109
J9 J SEX MED
JI J. Sex. Med.
PD APR
PY 2011
VL 8
IS 4
BP 1123
EP 1130
DI 10.1111/j.1743-6109.2010.02174.x
PG 8
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 744SS
UT WOS:000289115400019
PM 21235723
DA 2025-06-11
ER

PT J
AU Di Majo, D
   Ricciardi, N
   Moncada, A
   Allegra, M
   Frinchi, M
   Di Liberto, V
   Pitonzo, R
   Rappa, F
   Saiano, F
   Vetrano, F
   Miceli, A
   Giglia, G
   Ferraro, G
   Sardo, P
   Gambino, G
AF Di Majo, Danila
   Ricciardi, Nicolo
   Moncada, Alessandra
   Allegra, Mario
   Frinchi, Monica
   Di Liberto, Valentina
   Pitonzo, Rosa
   Rappa, Francesca
   Saiano, Filippo
   Vetrano, Filippo
   Miceli, Alessandro
   Giglia, Giuseppe
   Ferraro, Giuseppe
   Sardo, Pierangelo
   Gambino, Giuditta
TI Golden Tomato Juice Enhances Hepatic PPAR-α Expression, Mitigates
   Metabolic Dysfunctions and Influences Redox Balance in a High-Fat-Diet
   Rat Model
SO ANTIOXIDANTS
LA English
DT Article
DE oxylipin; metabolic syndrome; PPAR-alpha; leptin; oxidative stress;
   functional food
ID PROLIFERATOR-ACTIVATED-RECEPTOR; OXIDATIVE STRESS LEVELS; ACID; GAMMA;
   SUPPLEMENTATION; DEFINITION; PROMOTER; IMPACT; LEVEL; LIVER
AB Golden tomato (GT), harvested at the veraison stage, has gained attention due to its rich content of bioactive compounds and potential health benefits. Previous studies have highlighted GT's antioxidant properties and its positive effects on metabolic syndrome (MetS), a condition characterized by obesity, dyslipidemia, and oxidative stress. This study investigates for the first time a derivative from GT, i.e., the juice (GTJ), which could be a potential candidate for development as a functional food. We first characterized GT juice, identifying 9-oxo-10(E),12(E)-octadecadienoic (9-oxo-10(E),12(E)-ODA) fatty acid, a known peroxisome proliferator-activated receptor alpha (PPAR-alpha) agonist, using High-Performance Liquid Chromatography (HPLC)-mass spectrometry. Then, using a high-fat-diet (HFD) rat model, we assessed the impact of daily GT juice supplementation in addressing MetS. We outlined that GTJ improved body weight and leptin-mediated food intake. Moreover, it ameliorated glucose tolerance, lipid profile, systemic redox homeostasis, hepatic oxidative stress, and steatosis in HFD rats. Furthermore, GT juice enhances the hepatic transcription of PPAR-alpha, thus putatively promoting fatty acid oxidation and lipid metabolism. These findings suggest that GT juice mitigates lipidic accumulation and putatively halters oxidative species at the hepatic level through PPAR-alpha activation. Our study underscores the protective effects of GT juice against MetS, highlighting its future potential as a nutraceutical for improving dysmetabolism and associated alterations.
C1 [Di Majo, Danila; Ricciardi, Nicolo; Frinchi, Monica; Di Liberto, Valentina; Rappa, Francesca; Giglia, Giuseppe; Ferraro, Giuseppe; Sardo, Pierangelo; Gambino, Giuditta] Univ Palermo, Dept Biomed Neurosci & Adv Diagnost BIND, I-90127 Palermo, Italy.
   [Di Majo, Danila; Allegra, Mario; Giglia, Giuseppe; Ferraro, Giuseppe; Sardo, Pierangelo; Gambino, Giuditta] Univ Palermo, Postgrad Sch Nutr & Food Sci, I-90100 Palermo, Italy.
   [Moncada, Alessandra; Saiano, Filippo; Vetrano, Filippo; Miceli, Alessandro] Univ Palermo, Dept Agr Food & Forest Sci SAAF, I-90128 Palermo, Italy.
   [Allegra, Mario] Univ Palermo, Dept Biol Chem & Pharmaceut Sci & Technol STEBICEF, Viale Sci, I-90128 Palermo, Italy.
   [Pitonzo, Rosa] ATeN Adv Technol Network Ctr, I-90128 Palermo, Italy.
   [Giglia, Giuseppe] Euro Mediterranean Inst Sci & Technol IEMEST, I-90139 Palermo, Italy.
C3 University of Palermo; University of Palermo; University of Palermo;
   University of Palermo
RP Di Majo, D (corresponding author), Univ Palermo, Dept Biomed Neurosci & Adv Diagnost BIND, I-90127 Palermo, Italy.; Di Majo, D (corresponding author), Univ Palermo, Postgrad Sch Nutr & Food Sci, I-90100 Palermo, Italy.
EM danila.dimajo@unipa.it; nicolo.ricciardi@unipa.it;
   alessandra.moncada@unipa.it; mario.allegra@unipa.it;
   monica.frinchi@unipa.it; valentina.diliberto@unipa.it;
   rosa.pitonzo@unipa.it; francesca.rappa@unipa.it;
   filippo.saiano@unipa.it; filippo.vetrano@unipa.it;
   alessandro.miceli@unipa.it; giuseppe.giglia@unipa.it;
   giuseppe.ferraro@unipa.it; pierangelo.sardo@unipa.it;
   giuditta.gambino@unipa.it
RI Moncada, alessandra/GYR-3695-2022; Miceli, Alessandro/HLW-5981-2023; Di
   Majo, Danila/A-9078-2015; Allegra, Mario/AAG-3256-2019; Giglia,
   Giuseppe/M-7100-2016; Di+Liberto, Valentina/ACL-0264-2022; Francesca,
   Rappa/ADW-8431-2022
OI Frinchi, Monica/0000-0002-1061-5725
FU FFR 2023 [FFR 2023]; University of Palermo [DR41862023, Rep.Numb.:
   1105/2023]
FX This work was supported partly via funds "FFR 2023" provided to Gambino
   and Di Majo by University of Palermo and partly with funds "INCENTIVI AD
   ATTIVITA' DI RICERCA INTERDISCIPLINARE DR41862023" (Rep.Numb.:
   1105/2023, Prot.Numb.:135120/2023) provided to Danila Di Majo by
   University of Palermo.
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NR 63
TC 0
Z9 0
U1 2
U2 2
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD NOV
PY 2024
VL 13
IS 11
AR 1324
DI 10.3390/antiox13111324
PG 22
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA N3S4R
UT WOS:001363575800001
PM 39594468
OA gold
DA 2025-06-11
ER

PT J
AU Kishi, T
   Hirooka, Y
   Ogawa, K
   Konno, S
   Sunagawa, K
AF Kishi, Takuya
   Hirooka, Yoshitaka
   Ogawa, Kiyohiro
   Konno, Satomi
   Sunagawa, Kenji
TI Calorie Restriction inhibits Sympathetic Nerve Activity via Anti-Oxidant
   Effect in the Rostral Ventrolateral Medulla of Obesity-Induced
   Hypertensive Rats
SO CLINICAL AND EXPERIMENTAL HYPERTENSION
LA English
DT Article; Proceedings Paper
CT 12th Japanese Annual Conference on Chronocardiology and Hypertension
CY JUL 10, 2010
CL Tokyo, JAPAN
SP Mitsubishi Tanabe Pharma Corp
DE calorie restriction; metabolic syndrome; sympathetic nerve activity;
   oxidative stress; brain
ID NITRIC-OXIDE SYNTHASE; OXIDATIVE STRESS; ANGIOTENSIN-II; BLOOD-PRESSURE;
   BRAIN-STEM; PRONE; SYMPATHOEXCITATION; OVEREXPRESSION; ACTIVATION; MODEL
AB In the patients and animals with metabolic syndrome (MetS), sympathetic nerve activity (SNA) is increased. We have demonstrated that oxidative stress in the rostral ventrolateral medulla (RVLM), a vasomotor center in the brainstem, increases SNA. The aim of the present study was to determine whether calorie restriction inhibits SNA via anti-oxidant effect in the RVLM of obesity-induced obesity rats. Male Sprague-Dawley rats were fed on a high-fat diet and segregated into obesity-prone (OP) showing a MetS profile and obesity-resistant (OR) after 13 weeks. Obesity-prone was divided into OP treated with calorie restriction (CR-OP) for 8 weeks and control (CTR-OP). Systolic blood pressure (SBP), heart rate (HR), SNA, and thiobarbituric acid-reactive substances (TBARS) levels as a marker of oxidative stress in the RVLM were significantly higher and the depressor effects due to the microinjection of tempol, a superoxide dismutase mimetic into the RVLM, were significantly greater in OP than in OR. Body weight was significantly lower in CR-OP than in CTR-OP. SBP, HR, SNA, TBARS, and the depressor effects due to the microinjection of tempol into the RVLM were significantly lower in CR-OP than in CTR-OP. These results suggest that calorie restriction inhibits SNA via anti-oxidant effect in the RVLM of obesity-induced obesity rats.
C1 [Kishi, Takuya] Kyushu Univ, Grad Sch Med Sci, Dept Adv Therapeut Cardiovasc Dis, Dept Cardiovasc Med,Higashi Ku, Fukuoka 8128582, Japan.
C3 Kyushu University
RP Kishi, T (corresponding author), Kyushu Univ, Grad Sch Med Sci, Dept Adv Therapeut Cardiovasc Dis, Dept Cardiovasc Med,Higashi Ku, 3-1-1 Maidashi, Fukuoka 8128582, Japan.
EM tkishi@cardiol.med.kyushu-u.ac.jp
RI Kishi, Takuya/ITU-1075-2023
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NR 32
TC 31
Z9 31
U1 0
U2 4
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1064-1963
EI 1525-6006
J9 CLIN EXP HYPERTENS
JI Clin. Exp. Hypertens.
PY 2011
VL 33
IS 4
BP 240
EP 245
DI 10.3109/10641963.2011.583969
PG 6
WC Pharmacology & Pharmacy; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Pharmacology & Pharmacy; Cardiovascular System & Cardiology
GA 782VM
UT WOS:000292040800006
PM 21699450
DA 2025-06-11
ER

PT J
AU Campanholo, CB
   Maharaj, AB
   Corp, N
   Bell, S
   Costa, L
   de Vlam, K
   Gullick, NJ
   Khraishi, M
   Kishimoto, M
   Palmou-Fontana, N
   Reddy, S
   Scarpa, R
   Vega, L
   Duarte, GV
   Zisman, D
   Windt, DAV
   Duruoz, MT
   Ogdie, A
AF Campanholo, Cristiano B.
   Maharaj, Ajesh B.
   Corp, Nadia
   Bell, Stacie
   Costa, Luisa
   de Vlam, Kurt
   Gullick, Nicola J.
   Khraishi, Majed
   Kishimoto, Mitsumasa
   Palmou-Fontana, Natalia
   Reddy, Soumya
   Scarpa, Raffaele
   Vega, Luis
   Duarte, Gleison Vieira
   Zisman, Devy
   Windt, Danielle A. van der
   Duruoz, Mehmet T.
   Ogdie, Alexis
TI Management of Psoriatic Arthritis in Patients With Comorbidities: An
   Updated Literature Review Informing the 2021 GRAPPA Treatment
   Recommendations
SO JOURNAL OF RHEUMATOLOGY
LA English
DT Review
DE comorbidities; GRAPPA; psoriatic arthritis; treatments
ID METABOLIC SYNDROME; RHEUMATOID-ARTHRITIS; INCREASED PREVALENCE;
   WEIGHT-LOSS; TNF-ALPHA; RISK; DISEASE; SECUKINUMAB; METHOTREXATE;
   MALIGNANCY
AB Objective. The 2021 Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) treatment recommendations provide an evidence-based guide for selecting therapy based on the individual's disease features. Beyond the disease features and associated conditions (eg, uveitis and inflammatory bowel disease), comorbidities play an important role in selecting therapy for an individual patient.Methods. We performed a systematic literature review. We examined the available evidence to inform treat-ment selection based on the presence or absence of comorbidities in psoriatic arthritis (PsA). Results. Common comorbidities in PsA that may affect treatment selection include presence of baseline car-diovascular disease (CVD) or high risk for CVD, obesity and metabolic syndrome, liver disease, mood dis-orders, including depression in particular, chronic infections, malignancies, osteoporosis, and fibromyalgia and/or central sensitization.Conclusion. Comorbidities may influence both the effectiveness of a given therapy but also the potential for adverse events. It is important to assess for the presence of comorbidities prior to therapy selection.
C1 [Maharaj, Ajesh B.] Life Westville Hosp, Life Healthcare, Westville, South Africa.
   [Corp, Nadia] Keele Univ, Sch Med, Primary Care Ctr Versus Arthrit, Keele, Staffs, England.
   [Bell, Stacie] Natl Psoriasis Fdn, Portland, OR USA.
   [Costa, Luisa] Univ Naples Federico II, Dept Clin Med & Surg, Naples, Italy.
   [de Vlam, Kurt] Univ Hosp Leuven, Dept Rheumatol, Leuven, Belgium.
   [Gullick, Nicola J.] Univ Warwick, Univ Hosp Coventry Warwickshire, Dept Rheumatol, Coventry, W Midlands, England.
   [Gullick, Nicola J.] Univ Warwick, Warwick Med Sch, Coventry, W Midlands, England.
   [Khraishi, Majed] Mem Univ Newfoundland, St John, NF, Canada.
   [Kishimoto, Mitsumasa] Kyorin Univ, Dept Nephrol & Rheumatol, Sch Med, Tokyo, Japan.
   [Palmou-Fontana, Natalia] Marques Valdecilla Univ Hosp, Rheumatol Deparment, Cantabria, Spain.
   [Reddy, Soumya] NYU, Grossman Sch Med, New York, NY USA.
   [Scarpa, Raffaele] Univ Naples Federico II, Dept Clin Med & Surg, Naples, Italy.
   [Vega, Luis] Cent Hosp Peruvian Air Force, Rheumatol Sect, Lima, Peru.
   [Duarte, Gleison Vieira] Inst Bahiano Imunoterapia, Dermatol Div IBIS, Salvador, BA, Brazil.
   [Zisman, Devy] Carmel Hosp, Rheumatol Unit, Techn, Haifa, Israel.
   [Zisman, Devy] Ruth & Bruce Rappaport Fac Med, Techn, Haifa, Israel.
   [Windt, Danielle A. van der] Keele Univ, Sch Med, Primary Care Ctr Versus Arthrit, Keele, Staffs, England.
   [Duruoz, Mehmet T.] Marmara Univ, Div Rheumatol, PMR Dept, Sch Med, Istanbul, Turkiye.
   [Ogdie, Alexis] Univ Penn, Perelman Sch Med, Philadelphia, PA USA.
C3 Keele University; University of Naples Federico II; KU Leuven;
   University Hospital Leuven; University of Warwick; University of
   Warwick; Memorial University Newfoundland; Kyorin University; Hospital
   Universitario Marques de Valdecilla (HUMV); New York University;
   University of Naples Federico II; Clalit Health Services; Carmel Medical
   Center; Technion Israel Institute of Technology; Rappaport Faculty of
   Medicine; Keele University; Marmara University; University of
   Pennsylvania
RP Ogdie, A (corresponding author), Univ Pennsylvania, Perelman Sch Med, White 5023,3400 Spruce St, Philadelphia, PA 19104 USA.
EM ogdiea@pennmedicine.upenn.edu
RI Gullick, Nicola/GWZ-1369-2022; Corp, Nadia/G-8618-2012; PALMOU-FONTANA,
   NATALIA/AAZ-6454-2020; Duruöz, Mehmet Tuncay/I-2307-2016; Maharaj,
   Ajesh/M-3138-2014
OI kishimoto, Mitsumasa/0000-0002-4007-1589; Bell,
   Stacie/0000-0002-9987-567X; Corp, Nadia/0000-0002-6758-9513; Gullick,
   Nicola/0000-0001-8970-4116; van der Windt, Danielle/0000-0002-7248-6703;
   Maharaj, Ajesh/0000-0002-9436-4328; Palmou Fontana,
   Natalia/0000-0002-8609-0283
FU AbbVie; AstraZeneca; Izana; Lilly; Novartis; Pfizer; UCB; MSD; Amgen
FX ABM is a consultant and received honoraria from Janssen, ThermoFisher,
   Roche, Novartis, AbbVie, Eli Lilly, AstraZeneca, Pfizer, Zydus. LC
   received consultancy fees and/or lecturers' honoraria from AbbVie,
   Amgen, Novartis, Janssen, Lilly. NC consulted for and received honoraria
   from AbbVie, Celgene, Janssen, Lilly, Novartis, Pfizer, and UCB; and
   research funding from AbbVie, AstraZeneca, Izana, Lilly, and Novartis;
   and conference support from Celgene, Janssen, Lilly, UCB. M. Khraishi is
   a consultant for AbbVie, Amgen, Eli Lilly, Novartis, Pfizer. M.
   Kishimoto received consulting fees and/or lecturers' honoraria from
   AbbVie, Amgen-Astellas, Asahi-Kasei, Astellas, Ayumi, BMS, Chugai,
   Daiichi-Sankyo, Eisai, Eli Lilly, Gilead, Janssen, Kyowa Kirin,
   Novartis, Ono, Pfizer, Tanabe-Mitsubishi, Teijin, UCB. SR has consulted
   for Novartis, Janssen, AbbVie, UCB. GVD received consultancy fees and/or
   lecturers' honoraria from Novartis, Janssen, AbbVie, Lilly, UCB,
   Sanofi-Aventis. RS received consultancy fees and/or lecturers' honoraria
   from AbbVie, Amgen, Novartis, Lilly. DZ received consulting fees and/or
   lecturers' honoraria from AbbVie, Eli Lilly, Gilead, Janssen, Novartis,
   Pfizer; and grant support from Pfizer, UCB, MSD. MTD received
   consultancy fees and/or lecturers' honoraria from AbbVie, Amgen,
   Novartis, Janssen, Lilly. AO has consulted for AbbVie, Amgen, BMS,
   Celgene, CorEvitas, Gilead, Janssen, Kopa, Lilly, MoonLake, Novartis,
   Pfizer, UCB; and has received grant support from AbbVie, Amgen,
   Novartis, Pfizer. CBC, SB, KdeV, NJG, NPF, LV, and DAvdW declare no
   conflicts relevant to this article.
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NR 50
TC 16
Z9 16
U1 1
U2 2
PU J RHEUMATOL PUBL CO
PI TORONTO
PA 365 BLOOR ST E, STE 901, TORONTO, ONTARIO M4W 3L4, CANADA
SN 0315-162X
EI 1499-2752
J9 J RHEUMATOL
JI J. Rheumatol.
PD MAR 1
PY 2023
VL 50
IS 3
BP 426
EP 432
DI 10.3899/jrheum.220310
PG 7
WC Rheumatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Rheumatology
GA I7ST6
UT WOS:001004755200018
PM 36319003
OA Bronze, Green Published, Green Accepted
DA 2025-06-11
ER

PT J
AU Baskaran, A
   Cha, DS
   Powell, AM
   Jalil, D
   McIntyre, RS
AF Baskaran, Anusha
   Cha, Danielle S.
   Powell, Alissa M.
   Jalil, Dalya
   McIntyre, Roger S.
TI Sex differences in rates of obesity in bipolar disorder: postulated
   mechanisms
SO BIPOLAR DISORDERS
LA English
DT Review
DE bipolar disorder; female; metabolic syndrome; obesity; women
ID POLYCYSTIC-OVARY-SYNDROME; METABOLIC SYNDROME; WEIGHT-GAIN;
   GENDER-DIFFERENCES; UNITED-STATES; BODY-MASS; DEPRESSIVE SYMPTOMS;
   REPRODUCTIVE EVENTS; MOOD DISORDERS; WOMEN
AB ObjectiveThe increased standardized mortality ratio (SMR) from cardiovascular disease (CVD) in women with bipolar disorder (BD), relative to men with BD and individuals of both sexes in the general population, provides the impetus to identify factors that contribute to the differential association of obesity with BD in women.
   MethodsWe conducted a selective PubMed search of English-language articles published from September 1990 to June 2012. The key search terms were bipolar disorder and metabolic syndrome cross-referenced with gender, sex, obesity, diabetes mellitus, hypertension, and dyslipidemia. The search was supplemented with a manual review of relevant article reference lists. Articles selected for review were based on author consensus, the use of a standardized experimental procedure, validated assessment measures, and overall manuscript quality.
   ResultsIt is amply documented that adults with BD are affected by the metabolic syndrome at a rate higher than the general population. Women with BD, when compared to men with BD and individuals of both sexes in the general population, have higher rates of abdominal obesity. The course and clinical presentation of BD manifest differently in men and women, wherein women exhibit a higher frequency of depression predominant illness, a later onset of BD, more seasonal variations in mood disturbance, and increased susceptibility to relapse. Phenomenological factors can be expanded to include differences in patterns of comorbidity between the sexes among patients with BD. Other factors that contribute to the increased risk for abdominal obesity in female individuals with BD include reproductive life events, anamnestic (e.g., sexual and/or physical abuse), lifestyle, and iatrogenic.
   ConclusionsA confluence of factors broadly categorized as broad- and sex-based subserve the increased rate of obesity in women with BD. It remains a testable hypothesis that the increased abdominal obesity in women with BD mediates the increased SMR from CVD. A clinical recommendation that emerges from this review is amplified attention to the appearance, or history, of factors that conspire to increase obesity in female patients with BD.
C1 [Baskaran, Anusha] Queens Univ, Ctr Neurosci Studies, Kingston, ON, Canada.
   [Baskaran, Anusha; Cha, Danielle S.; Powell, Alissa M.; Jalil, Dalya; McIntyre, Roger S.] Univ Toronto, Mood Disorders Psychopharmacol Unit, Univ Hlth Network, Toronto, ON M5T 2S8, Canada.
   [Cha, Danielle S.; Powell, Alissa M.; McIntyre, Roger S.] Univ Toronto, Dept Psychiat, Toronto, ON M5T 2S8, Canada.
C3 Queens University - Canada; University of Toronto; University Health
   Network Toronto; University of Toronto
RP McIntyre, RS (corresponding author), Univ Toronto, Mood Disorders Psychopharmacol Unit, Univ Hlth Network, Dept Psychiat, 399 Bathurst St, Toronto, ON M5T 2S8, Canada.
EM roger.mcintyre@uhn.ca
RI McIntyre, Roger/AAU-1000-2020
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NR 92
TC 37
Z9 39
U1 1
U2 14
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1398-5647
EI 1399-5618
J9 BIPOLAR DISORD
JI Bipolar Disord.
PD FEB
PY 2014
VL 16
IS 1
SI SI
BP 83
EP 92
DI 10.1111/bdi.12141
PG 10
WC Clinical Neurology; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA AA6IT
UT WOS:000331202700009
PM 24467470
DA 2025-06-11
ER

PT J
AU Karagüzel, EO
   Kural, BV
   Tiryaki, A
   Altun, IK
   Özer, SY
   Arslan, FC
AF Karaguzel, Evrim Ozkorumak
   Kural, Birgul Vanizor
   Tiryaki, Ahmet
   Altun, Ilkay Keles
   Ozer, Serap Yaman
   Arslan, Filiz Civil
TI Blood levels of agouti-related peptide (AgRP), obestatin,
   corticosteroid-binding globulin (CBG), and cortisol in patients with
   bipolar disorder (BD): a case-control study
SO PSYCHIATRY AND CLINICAL PSYCHOPHARMACOLOGY
LA English
DT Article
DE Bipolar disorder; agouti-related protein; hydrocortisone;
   corticosteroid-binding globulin; obesity
ID PITUITARY-ADRENAL AXIS; METABOLIC SYNDROME; ENERGY-BALANCE;
   RATING-SCALE; GHRELIN; PROTEIN; OBESITY; SECRETION; SCHIZOPHRENIA;
   RELIABILITY
AB OBJECTIVES: Bipolar disorder (BD) is a chronic psychiatric disorder with a high prevalence of obesity. There are a number of hypotheses regarding the association between obesity and BD. One involves common neurobiological abnormalities, such as dysfunction in the hypothalamic pituitary adrenal axis and changes in secretions of orexigenic and anorectic peptides. The purpose of this study was to evaluate the blood levels of agouti-related peptide (AgRP), obestatin cortisol, and corticosteroid-binding globulin (CBG) and metabolic parameters in patients with euthymic BD, and to compare these to those of healthy controls. METHODS: Twenty-nine outpatients with BD type I admitted to the psychiatric clinic were consecutively enrolled and compared with 25 sex- and body mass index (BMI)-matched controls. RESULTS: There was a significant difference in AgRP, cortisol, and CBG levels between patients and the controls (p = .005, .021, and .034, respectively). AgRP and CBG did not correlate with any parameter in BD patients, but cortisol correlated with BMI. CONCLUSIONS: We conclude that BD patients have higher levels of AgRP, cortisol, and CBG than healthy controls with similar BMIs. This may represent a new insight into the neurobiology of BD.
C1 [Karaguzel, Evrim Ozkorumak; Arslan, Filiz Civil] Karadeniz Tech Univ, Fac Med, Dept Psychiat, TR-61080 Trabzon, Turkey.
   [Kural, Birgul Vanizor; Ozer, Serap Yaman] Karadeniz Tech Univ, Fac Med, Dept Med Biochem, Trabzon, Turkey.
   [Tiryaki, Ahmet] Istanbul Aydin Univ, Fac Med, Dept Psychiat, Istanbul, Turkey.
   [Altun, Ilkay Keles] Numune State Hosp, Dept Psychiat, Trabzon, Turkey.
C3 Karadeniz Technical University; Karadeniz Technical University; Istanbul
   Aydin University; Fatih State Hospital
RP Karagüzel, EO (corresponding author), Karadeniz Tech Univ, Fac Med, Dept Psychiat, TR-61080 Trabzon, Turkey.
EM evrimozkorumak@yahoo.com
RI tiryaki, ahmet/GVT-2792-2022; arslan, filiz/N-5677-2019; ozer,
   serap/MDS-9620-2025; Keles Altun, Ilkay/MXL-8477-2025
OI VANIZOR KURAL, Birgul/0000-0003-0730-9660; ozkorumak,
   evrim/0000-0002-0734-5437
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NR 44
TC 5
Z9 5
U1 0
U2 6
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 2475-0573
EI 2475-0581
J9 PSYCHIAT CLIN PSYCH
JI Psychiatry Clin. Psychopharmacol.
PD JAN 2
PY 2019
VL 29
IS 1
BP 14
EP 20
DI 10.1080/24750573.2018.1487649
PG 7
WC Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Psychiatry
GA HP2KT
UT WOS:000461499800003
OA gold
DA 2025-06-11
ER

PT J
AU Fenercioglu, AK
AF Fenercioglu, Aysen Kutan
TI The Anti-Inflammatory Roles of Vitamin D for Improving Human Health
SO CURRENT ISSUES IN MOLECULAR BIOLOGY
LA English
DT Review
DE vitamin D; inflammation; autoimmune disease; immune activation
ID INSULIN-RESISTANCE; METABOLIC SYNDROME; SJOGRENS-SYNDROME; D DEFICIENCY;
   D-3; INFLAMMATION; ASSOCIATION
AB Vitamin D receptors (VDRs) are present in almost all cells of the immune system, including B cells, T cells, NK (Natural Killer) cells, dendritic cells, and monocytes, as well as the epithelial cells of many organs such as the intestine, pancreas, prostate, lungs, and cardiomyocytes. In addition, some immune cells, including dendritic cells, macrophages, and B and T cells, can synthesize calcitriol by expressing 1 alpha-hydroxylase. Upon binding to VDRs, vitamin D (Vit D) regulates the expression of genes involved in immune responses, including those encoding for cytokines. It modulates the production of pro-inflammatory cytokines while promoting the synthesis of anti-inflammatory cytokines. Vit D also affects the differentiation and maturation of cells of the immune system. By inhibiting the nuclear factor kappa B (NF-kappa B) and mitogen-activated protein kinase (MAPK) pathways, Vit D reduces the expression of pro-inflammatory genes. These effects highlight the potential of Vit D as a therapeutic agent in the management of inflammatory diseases, including autoimmune disorders, cardiovascular diseases, diabetes, metabolic syndrome, cancer, neurological diseases, depression, and inflammatory bowel disease.
C1 [Fenercioglu, Aysen Kutan] Istanbul Univ Cerrahpasa, Cerrahpasa Med Fac, Dept Family Med, TR-34098 Istanbul, Turkiye.
C3 Istanbul University - Cerrahpasa
RP Fenercioglu, AK (corresponding author), Istanbul Univ Cerrahpasa, Cerrahpasa Med Fac, Dept Family Med, TR-34098 Istanbul, Turkiye.
EM aysen.fenercioglu@iuc.edu.tr
RI Kutan Fenercioglu, Aysen/L-9876-2013
OI Kutan Fenercioglu, Aysen/0000-0003-2965-6102
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   Zhang ZS, 2024, HELIYON, V10, DOI 10.1016/j.heliyon.2023.e23674
NR 59
TC 11
Z9 11
U1 7
U2 7
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1467-3037
EI 1467-3045
J9 CURR ISSUES MOL BIOL
JI Curr. Issues Mol. Biol.
PD DEC
PY 2024
VL 46
IS 12
BP 13514
EP 13525
DI 10.3390/cimb46120807
PG 12
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA Q3O6S
UT WOS:001383822800001
PM 39727935
OA gold
DA 2025-06-11
ER

PT J
AU Bytyçi, I
   Bengrid, TM
   Henein, MY
AF Bytyci, Ibadete
   Bengrid, Tarek M.
   Henein, Michael Y.
TI Longitudinal myocardial function is more compromised in cardiac syndrome
   X compared to insignificant CAD: Role of stress echocardiography and
   calcium scoring
SO CLINICAL PHYSIOLOGY AND FUNCTIONAL IMAGING
LA English
DT Article
DE cardiac syndrome X; coronary artery calcium score; dobutamine stress
   echocardiography; insignificant coronary artery disease
ID CORONARY-ARTERY-DISEASE; LONG-AXIS FUNCTION; DOBUTAMINE STRESS; EUROPEAN
   ASSOCIATION; COMPUTED-TOMOGRAPHY; NATURAL-HISTORY; ANGINA-PECTORIS;
   STABLE ANGINA; CALCIFICATION; ANGIOGRAPHY
AB Background and Aim The aim of this study was to assess the nature of myocardial dysfunction in the cardiac syndrome X (CSX) and insignificant coronary artery disease (ICAD) using dobutamine stress echocardiography (DSE) and coronary calcium scoring (CAC). Methods We prospectively studied 35 consecutive patients who complained of exertional angina, had >= 1 mm ST shift on exercise stress test but normal or no obstructive CAD (<50%) on angiography. Patients were divided into CSX (n = 27) with normal arteries and ICAD (n = 8) with insignificant stenosis. Results CSX patients had more females, lower calcium score and less prevalent cardiac risk factors compared to ICAD (p < 0.05 for all). At peak stress, MAPSE and TAPSE failed to increase in both groups. LV septal and lateral s' increased in the two groups but the increment increase was less in CSX than ICAD (p < 0.05) while other diastolic indices did not differ between groups (p > 0.05 for all). CAC correlated modestly with LV and RV systolic velocities: septal s' (r = -0.65, p < 0.001) lateral s' (r = -0.35, p = 0.04) and right s' (r = -0.53, p = 0.005) in CSX, while in ICAD patients only with RV s' (r = -0.58, p = 0.02). On multivariate model, only septal s' OR 1.816 (1.1090-3.820, p = 0.04) proved the most powerful independent predictor of CAC. Conclusions Compromised LV longitudinal systolic velocities were more pronounced and calcium score as a surrogate for atherosclerosis was lower in CSX than ICAD. These findings strengthen the evidence for different pathogenesis of CSX compared to ICAD, with microvascular disease in the former and calcification in the latter.
C1 [Bytyci, Ibadete; Henein, Michael Y.] Umea Univ, Inst Publ Hlth & Clin Med, S-90187 Umea, Sweden.
   [Bytyci, Ibadete] Univ Clin Ctr Kosovo, Clin Cardiol, Prishtina 10000, Kosovo.
   [Bengrid, Tarek M.] Tripoli Univ, Tripoli 13275, Libya.
   [Henein, Michael Y.] London & Brunel Univ, Mol & Clin Res Inst, St George Univ, London UB8 3PH, England.
C3 Umea University; Universiteti i Prishtines; University of Tripoli; City
   St Georges, University of London; St Georges University London
RP Henein, MY (corresponding author), Umea Univ, Inst Publ Hlth & Clin Med, S-90187 Umea, Sweden.
EM michael.henein@umu.se
RI Bytyçi, Ibadete/L-1767-2018
OI Bytyci, Ibadete/0000-0002-8996-4257
CR Agrawal S, 2014, CARDIOL CLIN, V32, P463, DOI 10.1016/j.ccl.2014.04.006
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NR 38
TC 2
Z9 2
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1475-0961
EI 1475-097X
J9 CLIN PHYSIOL FUNCT I
JI Clin. Physiol. Funct. Imaging
PD JAN
PY 2022
VL 42
IS 1
BP 35
EP 42
DI 10.1111/cpf.12733
EA NOV 2021
PG 8
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA YC1EP
UT WOS:000717917800001
PM 34716983
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Freese, EC
   Acitelli, RM
   Gist, NH
   Cureton, KJ
   Evans, EM
   O'Connor, PJ
AF Freese, Eric C.
   Acitelli, Rachelle M.
   Gist, Nicholas H.
   Cureton, Kirk J.
   Evans, Ellen M.
   O'Connor, Patrick J.
TI Effect of Six Weeks of Sprint Interval Training on Mood and Perceived
   Health in Women at Risk for Metabolic Syndrome
SO JOURNAL OF SPORT & EXERCISE PSYCHOLOGY
LA English
DT Article
DE exercise psychology; exercise training; health behavior
ID QUALITY-OF-LIFE; POSTPRANDIAL LIPEMIA; PHYSICAL-ACTIVITY; EXERCISE;
   ADAPTATIONS; SYMPTOMS; CAPACITY; MUSCLE; PERFORMANCE; DEPRESSION
AB The purpose of this investigation was to determine whether 6 weeks of sprint interval training (SIT) is associated with changes in mood and perceived health in women at risk for developing metabolic syndrome (MetS). Physically inactive women (30-65 years) were randomized to 6 weeks of nutrition meetings and SIT (n = 23; 3 bouts/week of 4-8 30-s cycle sprints with 4-mM recovery) or a nonexercise control condition (CON; n = 24). Before and after the 6-week intervention, perceived health status and mood were assessed. Clinically relevant increases in role-physical scores (ES = 0.64) and vitality (ES = 0.52) were found after 6 weeks of SIT compared with a nonexercise control group. For middle-aged women at risk for MetS, it is concluded that high-intensity, low-volume SIT (1) increases feelings of vitality and perceptions of having fewer physical limitations and (2) does not induce mood disturbances as occurs with high-volume, high-intensity training.
C1 [Freese, Eric C.; Acitelli, Rachelle M.; Gist, Nicholas H.; Cureton, Kirk J.; Evans, Ellen M.; O'Connor, Patrick J.] Univ Georgia, Dept Kinesiol, Athens, GA 30602 USA.
   [Gist, Nicholas H.] US Mil Acad, Dept Phys Educ, West Point, NY 10996 USA.
C3 University System of Georgia; University of Georgia; United States
   Department of Defense; United States Army; United States Military
   Academy
RP Freese, EC (corresponding author), Univ Georgia, Dept Kinesiol, Athens, GA 30602 USA.
EM efreese2@gmail.com
RI O'Connor, Patrick/HII-2987-2022
OI Cureton, Kirk/0000-0003-4917-6587
FU Egg Nutrition Center
FX The authors thank Jeremy Dean, Sasha McBurse, and Chad Straight for
   their assistance with the exercise training and Catherine Beck and
   Whitni McConnell for their weight maintenance and dietary guidance. In
   addition, the authors thank the undergraduate research assistants in the
   Department of Kinesiology, especially Sara Dover and Rachel Butler, for
   their assistance with testing, data entry, and supervising exercise
   training sessions. This randomized clinical trial was supported by the
   Egg Nutrition Center. The authors declare no conflicts of interest.
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NR 31
TC 19
Z9 23
U1 0
U2 26
PU HUMAN KINETICS PUBL INC
PI CHAMPAIGN
PA 1607 N MARKET ST, PO BOX 5076, CHAMPAIGN, IL 61820-2200 USA
SN 0895-2779
EI 1543-2904
J9 J SPORT EXERCISE PSY
JI J. Sport Exerc. Psychol.
PD DEC
PY 2014
VL 36
IS 6
BP 610
EP 618
DI 10.1123/jsep.2014-0083
PG 9
WC Hospitality, Leisure, Sport & Tourism; Psychology, Applied; Psychology;
   Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Social Sciences - Other Topics; Psychology; Sport Sciences
GA AZ8UY
UT WOS:000348491000006
PM 25602143
DA 2025-06-11
ER

PT J
AU Abu-Zaid, A
   Baradwan, S
   Bukhari, IA
   Alyousef, A
   Abuzaid, M
   Saleh, SAK
   Adly, HM
   Alomar, O
   Al-Badawi, IA
AF Abu-Zaid, Ahmed
   Baradwan, Saeed
   Bukhari, Ibtihal Abdulaziz
   Alyousef, Abdullah
   Abuzaid, Mohammed
   Saleh, Saleh A. K.
   Adly, Heba M.
   Alomar, Osama
   Al-Badawi, Ismail Abdulrahman
TI The effect of alpha-lipoic acid supplementation on anthropometric,
   glycemic, lipid, oxidative stress, and hormonal parameters in
   individuals with polycystic ovary syndrome: a systematic review and
   meta-analysis of randomized clinical trials
SO OBSTETRICS & GYNECOLOGY SCIENCE
LA English
DT Review
DE Thioctic acid; Inositol; Polycystic ovary syndrome; Cardiometabolic risk
   factors
ID INSULIN SENSITIVITY; SIGNALING PATHWAY; QUALITY; WOMEN; ALA
AB This systematic review and meta-analysis aimed to examine the effect of the antioxidant alpha-lipoic acid (ALA) on various cardiometabolic risk factors and hormonal parameters in patients with polycystic ovary syndrome (PCOS). We searched PubMed, EMBASE, SCOPUS, Cochrane Library, and Web of Science databases without language restrictions until May 2023 to find randomized controlled trials (RCTs) that assessed the impact of ALA supplementation on anthropometric, glycemic, lipid, oxidative stress, and hormonal parameters in women with PCOS. Outcomes were summarized using the standardized mean difference (SMD) and 95% confidence interval (CI) in a random-effects model. An I2 statistic of >60% established significant between-study heterogeneity. The overall certainty of the evidence for each outcome was determined using the grading of recommendations, assessment, development, and evaluations system. Seven RCTs met the inclusion criteria. The ALA group had significant reductions in fasting blood sugar (fasting blood sugar (FBS), n=7 RCTs, SMD,-0.60; 95% CI,-1.10 to-0.10; I-2=63.54%, moderate certainty of evidence) and homeostatic model assessment for insulin resistance (homeostatic model assessment of insulin resistance (HOMA-IR), n=4 RCTs, SMD,-2.03; 95% CI,-3.85 to-0.20; I-2=96.32%, low certainty of evidence) compared with the control group. However, significant differences were observed between the groups in body mass index, insulin, estrogen, follicle-stimulating hormone, luteinizing hormone, testosterone, low-density lipoprotein, high density lipoprotein, triglyceride, total cholesterol, malondialdehyde, or total antioxidant capacity profiles. ALA supplementation improves FBS and HOMA-IR levels in women with PCOS. ALA consumption is an effective complementary therapy for the management of women with PCOS.
C1 [Abu-Zaid, Ahmed; Alomar, Osama; Al-Badawi, Ismail Abdulrahman] Alfaisal Univ, Coll Med, Dept Obstet & Gynecol, Al Zahrawi St, Riyadh 11533, Saudi Arabia.
   [Baradwan, Saeed] King Faisal Specialist Hosp & Res Ctr, Dept Obstet & Gynecol, Jeddah, Saudi Arabia.
   [Bukhari, Ibtihal Abdulaziz] Princess Nourah Bint Abdulrahman Univ, Coll Med, Dept Obstet & Gynecol, Riyadh, Saudi Arabia.
   [Alyousef, Abdullah] King Abdullah Bin Abdulaziz Univ Hosp, Dept Obstet & Gynecol, Riyadh, Saudi Arabia.
   [Abuzaid, Mohammed] Muhayil Gen Hosp, Dept Obstet & Gynecol, Muhayil, Saudi Arabia.
   [Saleh, Saleh A. K.] Umm Al Qura Univ, Fac Med, Dept Biochem, Mecca, Saudi Arabia.
   [Saleh, Saleh A. K.] Ain Shams Univ, Fac Med, Oncol Diagnost Unit, Cairo, Egypt.
   [Adly, Heba M.] Umm Al Qura Univ, Fac Med, Dept Community Med & Pilgrims Healthcare, Mecca, Saudi Arabia.
   [Alomar, Osama; Al-Badawi, Ismail Abdulrahman] King Faisal Specialist Hosp & Res Ctr, Dept Obstet & Gynecol, Riyadh, Saudi Arabia.
C3 King Faisal Specialist Hospital & Research Center; Princess Nourah bint
   Abdulrahman University; Umm Al-Qura University; Egyptian Knowledge Bank
   (EKB); Ain Shams University; Umm Al-Qura University; King Faisal
   Specialist Hospital & Research Center
RP Abu-Zaid, A (corresponding author), Alfaisal Univ, Coll Med, Dept Obstet & Gynecol, Al Zahrawi St, Riyadh 11533, Saudi Arabia.
EM aabuzaid@live.com
RI Saleh, Saleh/S-6837-2019; Adly, Prof Heba/IQU-8083-2023; Azzam,
   Ahmed/ITT-4117-2023; Baradwan, Saeed/I-3387-2019; bukhari,
   ibtihal/JQJ-5131-2023
OI Abu-Zaid, Ahmed/0000-0003-2286-2181; Alomar, Osama/0000-0003-4715-9396;
   Saleh, Saleh Ahmed/0000-0001-9522-9198
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NR 50
TC 3
Z9 3
U1 3
U2 6
PU Korean Soc Obstetrics and Gynecology (KSOG)
PI Seoul
PA 4th Floor, 36 Gangnam-daero 132-gil, Gangnam-gu, Seoul, SOUTH KOREA
SN 2287-8572
EI 2287-8580
J9 OBSTET GYNECOL SCI
JI Obstet. Gynecol. Sci.
PD JAN
PY 2024
VL 67
IS 1
BP 17
EP 29
DI 10.5468/ogs.23206
PG 13
WC Obstetrics & Gynecology
WE Emerging Sources Citation Index (ESCI)
SC Obstetrics & Gynecology
GA IF9D2
UT WOS:001165022800007
PM 38044616
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Reid, BM
   Harbin, MM
   Arend, JL
   Kelly, AS
   Dengel, DR
   Gunnar, MR
AF Reid, Brie M.
   Harbin, Michelle M.
   Arend, Jessica L.
   Kelly, Aaron S.
   Dengel, Donald R.
   Gunnar, Megan R.
TI Early Life Adversity with Height Stunting Is Associated with
   Cardiometabolic Risk in Adolescents Independent of Body Mass Index
SO JOURNAL OF PEDIATRICS
LA English
DT Article
ID PULSE-WAVE VELOCITY; HEART-RATE-VARIABILITY; ARTERIAL STIFFNESS;
   PROGNOSTIC VALUE; ENDOTHELIAL FUNCTION; AUGMENTATION INDEX; COMFORT
   FOODS; CHILDHOOD; STRESS; OBESITY
AB Objective To evaluate cardiovascular and metabolic function in youths adopted internationally from orphanages/institutions (postinstitutionalized) who were height-stunted at adoption.
   Study design A total of 30 postinstitutionalized youths (age, 9-18 years: body mass index [BMI] percentile, 7.2-90.4) who were height-stunted at adoption were compared with age- and BMI percentile-matched youths (n = 90). Measurements included total body fat and visceral adipose tissue (dual radiograph absorptiometry), arterial stiffness (augmentation index and pulse wave velocity), cardiac autonomic function (heart rate variability), blood pressure, and fasting lipid, glucose, and insulin levels. Linear regression analyses were computed controlling for parent education. age, trunk tissue fat, height-for-age, sex, and race.
   Results Compared with controls of the same age. sex. and BMI, the postinstitutionalized children had higher systolic blood pressure (P = .018), augmentation index (P = .033). total cholesterol (P = .047), low-density lipoprotein cholesterol (P = .03), triglycerides (P = .048), insulin (P = .005). and HOMA-IR (P= .01) values. The postinstitutionalized children had a lower low-frequency to high-frequency ratio (P= .008), indicating lower sympathetic tone. as well as a lower total lean mass (P= .016), a lower gynoid lean mass (P= .039), and a higher proportion of trunk tissue fat (P= .017). The postinstitutionalized and control children did not differ in any other body composition measures.
   Conclusions Early life stress, as represented by height-stunted growth in institutional care. may be associated with early pathways to cardiovascular and metabolic risk in youths even after moving into well-resourced homes early in life and in the absence of increased adiposity. These findings suggest that postinstitutionalized youths with a history of height stunting may need to be closely monitored for emergent cardiometabolic risk factors.
C1 [Reid, Brie M.; Arend, Jessica L.; Gunnar, Megan R.] Univ Minnesota, Inst Child Dev, 51 E River Rd, Minneapolis, MN 55455 USA.
   [Harbin, Michelle M.; Dengel, Donald R.] Univ Minnesota, Sch Kinesiol, Minneapolis, MN 55455 USA.
   [Arend, Jessica L.] Univ Minnesota, Med Sch, Dept Psychiat, Minneapolis, MN 55455 USA.
   [Kelly, Aaron S.; Dengel, Donald R.] Univ Minnesota, Med Sch, Dept Pediat, Ctr Pediat Obes Med, Minneapolis, MN 55455 USA.
C3 University of Minnesota System; University of Minnesota Twin Cities;
   University of Minnesota System; University of Minnesota Twin Cities;
   University of Minnesota System; University of Minnesota Twin Cities;
   University of Minnesota System; University of Minnesota Twin Cities
RP Reid, BM (corresponding author), Univ Minnesota, Inst Child Dev, 51 E River Rd, Minneapolis, MN 55455 USA.
EM reidx189@umn.edu
RI Reid, Brie/ABC-9782-2020
OI Dengel, Donald/0000-0001-9049-7548
FU National Heart, Lung, and Blood Institute [R01 HL110957]; National
   Center for Advancing Translational Sciences [UL1TR000114]; National
   Institute of Diabetes and Digestive and Kidney Diseases (NORC Grant)
   [P30 DK050456]; Canadian Institute for Advanced Research Child and Brain
   Development program; National Science Foundation Graduate Research
   Fellowship [00039202]
FX Funded by the National Heart, Lung, and Blood Institute (R01 HL110957,
   to A.K.), the National Center for Advancing Translational Sciences
   (UL1TR000114), the National Institute of Diabetes and Digestive and
   Kidney Diseases (NORC Grant P30 DK050456), and the Canadian Institute
   for Advanced Research Child and Brain Development program (to M.G.). The
   content is solely the responsibility of the authors and does not
   necessarily represent the official views of the National Institutes of
   Health. This material is based on work supported by the National Science
   Foundation Graduate Research Fellowship (Grant 00039202, to B.R.). Any
   opinion, findings, and conclusions or recommendations expressed in this
   material are those of the authors(s) and do not necessarily reflect the
   views of the National Science Foundation. A.K. serves as a consultant
   for Novo Nordisk, Orexigen, and Vivus Pharmaceuticals and receives
   research support from Astra Zeneca Pharmaceuticals in the form of
   drug/placebo. D.D. serves as a paid consultant for Hologic, Inc. The
   other authors declare no conflicts of interest.
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NR 58
TC 14
Z9 16
U1 0
U2 6
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0022-3476
EI 1097-6833
J9 J PEDIATR-US
JI J. Pediatr.
PD NOV
PY 2018
VL 202
BP 143
EP 149
DI 10.1016/j.jpeds.2018.06.047
PG 7
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Pediatrics
GA GX6YR
UT WOS:000447910300025
PM 30146113
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Ferreira, TD
   Fernandes, JFR
   Araújo, LD
   Nogueira, LD
   Leal, PM
   Antunes, VP
   Rodrigues, MDG
   Valença, DCT
   Kaiser, SE
   Klein, MRST
AF Ferreira, Thais da Silva
   Rodrigues Fernandes, Julia Freitas
   Araujo, Luciene da Silva
   Nogueira, Livia de Paula
   Leal, Priscila Mansur
   Antunes, Vanessa Parada
   Guimaraes Rodrigues, Maria de Lourdes
   Torres Valenca, Debora Cristina
   Kaiser, Sergio Emanuel
   Simas Torres Klein, Marcia Regina
TI Serum Uric Acid Levels are Associated with Cardiometabolic Risk Factors
   in Healthy Young and Middle-Aged Adults
SO ARQUIVOS BRASILEIROS DE CARDIOLOGIA
LA English
DT Article
DE Uric Acid/metabolism; Oxidative Stress; Inflammation; Endothelium/
   dysfunction; Adults
ID ENDOTHELIAL FUNCTION; ARTERIAL STIFFNESS; INFLAMMATION; DYSFUNCTION;
   OBESITY; ATHEROSCLEROSIS; ADIPONECTIN; BIOMARKERS; PLASMA
AB Background: Observational studies have highlighted an association between serum uric acid (SUA) levels and cardiovascular risk factors. Despite the growing body of evidences, several studies were conducted in older individuals or in carriers of diseases susceptible to affect SUA levels and cardiometabolic risk markers.
   Objective: To evaluate the relationship of SUA with body adiposity, metabolic profile, oxidative stress, inflammatory biomarkers, blood pressure and endothelial function in healthy young and middle-aged adults.
   Methods: 149 Brazilian adults aged 20-55 years, both sexes, underwent evaluation of body adiposity, SUA, fasting glucose and insulin, lipid profile, malondialdehyde (MDA), high sensitivity C-reactive protein (hs-CRP), adiponectin, blood pressure and endothelial function. Endothelial function was assessed by the reactive hyperemia index (RHI) derived from peripheral arterial tonometry method. Participants were allocated in two groups according to SUA levels: control group (CG; n = 130; men <= 7 mg/dL, women <= 6 mg/dL) and hyperuricemia group (HG; n = 19; men > 7 mg/dL, women > 6 mg/dL). A P-value < 0.05 was considered statistically significant.
   Results: After adjustment for confounders, participants in HG compared with those in CG displayed higher body mass index (BMI): 34.15(33.36-37.19) vs.31.80 (26.26-34.42) kg/m(2),p = 0.008, higher MDA: 4.67(4.03-5.30) vs. 3.53(3.10-4.07) ng/mL, p < 0.0001 and lower RHI: 1.68 +/- 0.30 vs. 2.05 +/- 0.46, p = 0.03). In correlation analysis adjusted for confounders, SUA was positively associated (p < 0.05) with BMI, waist circumference, LDL-cholesterol, triglycerides and MDA, and negatively associated (p < 0.05) with HDL-cholesterol, adiponectin and RHI.
   Conclusions: This study suggests that in healthy young and middle-aged adults higher SUA levels are associated with higher body adiposity, unfavorable lipid and inflammatory phenotype, higher oxidative stress and impaired endothelial function.
C1 [Ferreira, Thais da Silva] Univ Fed Estado Rio de Janeiro UNIRIO, Rio De Janeiro, RJ, Brazil.
   [Ferreira, Thais da Silva; Rodrigues Fernandes, Julia Freitas; Araujo, Luciene da Silva; Nogueira, Livia de Paula; Leal, Priscila Mansur; Antunes, Vanessa Parada; Guimaraes Rodrigues, Maria de Lourdes; Torres Valenca, Debora Cristina; Kaiser, Sergio Emanuel; Simas Torres Klein, Marcia Regina] Univ Estado Rio de Janeiro UERJ, Rio De Janeiro, RJ, Brazil.
C3 Universidade Federal do Estado do Rio de Janeiro; Universidade do Estado
   do Rio de Janeiro
RP Ferreira, TD (corresponding author), Dept Nutr Aplicada, Ave Pasteur,296 Predio Escola Nutr, BR-22290240 Rio De Janeiro, RJ, Brazil.
EM thaissferreira@gmail.com
RI antunes, vanessa/C-8225-2018; Klein, Marcia/AAA-1695-2022; Rodrigues,
   Maria/KFR-3007-2024
OI Klein, Marcia/0000-0003-0298-3613
FU Fundacao Carlos Chagas Filho de Amparo a Pesquisa do Estado do Rio de
   Janeiro (FAPERJ)
FX This study was funded by Fundacao Carlos Chagas Filho de Amparo a
   Pesquisa do Estado do Rio de Janeiro (FAPERJ).
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NR 40
TC 19
Z9 20
U1 0
U2 4
PU ARQUIVOS BRASILEIROS CARDIOLOGIA
PI RIO DE JANEIRO
PA AVENIDA MARECHAL CAMARA 160-330 CENTRO, RIO DE JANEIRO, RJ 20 020-907,
   BRAZIL
SN 0066-782X
EI 1678-4170
J9 ARQ BRAS CARDIOL
JI Arq. Bras. Cardiol.
PD DEC
PY 2018
VL 111
IS 6
BP 833
EP 840
DI 10.5935/abc.20180197
PG 8
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA HC6QZ
UT WOS:000451927700014
PM 30328946
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Chang, CH
AF Chang, Chia-Hao
TI Cohen's kappa for capturing discrimination
SO INTERNATIONAL HEALTH
LA English
DT Article
DE Area under the ROC curve; Cohen's kappa; Cut-off value; Power; Receiver
   operating characteristic curve
ID METABOLIC SYNDROME; CANCER; COEFFICIENT; PREVALENCE; DEPRESSION;
   PREDICTION; STROKE; TOOL
AB Identification of cut-off values for key biomarkers of clinical risk is a useful clinical tool. The kappa coefficient is a popular descriptive statistical measure for summarising the cross classification of two nominal variables with identical classes. On the basis of this definition, I propose that the kappa coefficient can also be used to capture discrimination, in the same way that the receiver operating characteristic (ROC) curve is used in preventive epidemiology studies.
   The statistics were determined using Cohen's kappa statistics for a gold standard and a continuous biomarker. The proposed design is compared with the ROC curve by applying it to articles on the metabolic syndrome and a colon cancer clinical trial.
   The two methods gave similar results. Moreover, Monte Carlo simulation results confirm that, from a power perspective, the proposed method is to be preferred. In general, the proposed method has higher power than the area under the ROC curve (AUC) for a study of positively correlative design.
   Overall, the power performance of the proposed method is better that that of the AUC.
C1 Chang Gung Univ Sci & Technol, Dept Nursing, Chiayi 61363, Taiwan.
C3 Chang Gung University of Science & Technology
RP Chang, CH (corresponding author), Chang Gung Univ Sci & Technol, Dept Nursing, Chiayi Campus, Chiayi 61363, Taiwan.
EM howellchang@gmail.com
FU Chang Gung Medical Research Grant [CMRPF680021, CMRPF690011]
FX This work was supported by Chang Gung Medical Research Grant [grant nos
   CMRPF680021, CMRPF690011].
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NR 28
TC 27
Z9 28
U1 2
U2 9
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1876-3413
EI 1876-3405
J9 INT HEALTH
JI Int. Health
PD JUN
PY 2014
VL 6
IS 2
BP 125
EP 129
DI 10.1093/inthealth/ihu010
PG 5
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA AJ6JM
UT WOS:000337799100009
PM 24691677
DA 2025-06-11
ER

PT J
AU Brunero, S
   Lamont, S
AF Brunero, Scott
   Lamont, Scott
TI Health behaviour beliefs and physical health risk factors for
   cardiovascular disease in an outpatient sample of consumers with a
   severe mental illness: A cross-sectional survey
SO INTERNATIONAL JOURNAL OF NURSING STUDIES
LA English
DT Article
DE Mental illness; Physical health; Health beliefs and attitudes
ID METABOLIC SYNDROME; SOCIOECONOMIC-STATUS; GENDER; CARE; CONSUMPTION;
   FAILURE; OBESITY; PEOPLE; IMPACT; RACE
AB Background Consumers with a mental illness have a significantly higher risk of physical health problems than the general population The role of health behaviour beliefs and their part in the health of consumers with a mental illness has been poorly explored in the literature
   Objectives To understand the relationship between physical health risk factors and health behaviour beliefs in consumers with schizophrenia
   Design A cross-sectional survey study design using the European Health and Behaviour Survey and assessing (n = 99) consumer's blood pressure, waist circumference, body mass index, smoking history, exercise levels, demographics, family history of diabetes and cardiovascular disease was used
   Settings The study was conducted in a 76-bed psychiatric facility located within a 550-bed metropolitan generalist hospital in Sydney, Australia
   Participants Patients attending an outpatient clozapine clinic at the mental health service were asked to participate in the survey by a nurse working in the clinic during the study period
   Results Of the 163 consumers asked to be involved in the study. 11 = 99 agreed to participate Mean waist circumference and body mass index for both males and females were significantly above normal population limits Overall, consumer's beliefs toward their health on the European Health and Behaviour Survey were positive, having statistically significantly more positive attitudes to the statements 'avoiding too much sugar', 'drinking no alcohol' and 'yearly blood pressure checks' than a previously published non-mental health consumer sample Whilst having positive attitude toward their healthcare, consumers' physical health risk parameters were higher than general population norms
   Conclusions Consumers with a mental illness have a significantly higher risk for serious physical health problems, yet possess high positive attitudes toward their physical health care. Models of care need to explore this contradiction within mental health services to improve patient outcomes. (C) 2009 Elsevier Ltd All rights reserved
C1 [Brunero, Scott; Lamont, Scott] NERU, EBB, Prince Wales Hosp, Sydney, NSW 2031, Australia.
C3 University of New South Wales Sydney; Prince of Wales Hospital (POWH)
RP Brunero, S (corresponding author), NERU, EBB, Prince Wales Hosp, Rm 7,High St, Sydney, NSW 2031, Australia.
RI brunero, scott/X-5634-2018; Lamont, Scott/KEH-2123-2024
OI Lamont, Scott/0000-0003-2497-1314; brunero, scott/0000-0003-4156-7014
FU New South Wales Nursing and Midwifery office Sydney Australia
FX The study was funded by the New South Wales Nursing and Midwifery office
   Sydney Australia.
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NR 57
TC 35
Z9 39
U1 0
U2 31
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0020-7489
EI 1873-491X
J9 INT J NURS STUD
JI Int. J. Nurs. Stud.
PD JUN
PY 2010
VL 47
IS 6
BP 753
EP 760
DI 10.1016/j.ijnurstu.2009.11.004
PG 8
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA 596HP
UT WOS:000277676100011
PM 19959166
DA 2025-06-11
ER

EF﻿FN Clarivate Analytics Web of Science
VR 1.0
PT J
AU Guimond, AJ
   Trudel-Fitzgerald, C
   Boehm, JK
   Qureshi, F
   Kubzansky, LD
AF Guimond, Anne-Josee
   Trudel-Fitzgerald, Claudia
   Boehm, Julia K.
   Qureshi, Farah
   Kubzansky, Laura D.
TI Is More, Better? Relationships of Multiple Psychological Well-Being
   Facets With Cardiometabolic Disease
SO HEALTH PSYCHOLOGY
LA English
DT Article
DE psychological well-being; cardiometabolic disease; trajectories;
   longitudinal study; psychosocial factors
ID QUALITY-OF-LIFE; CARDIOVASCULAR HEALTH; PSYCHOSOCIAL FACTORS; SAS
   PROCEDURE; RISK; STROKE; ASSOCIATION; DEPRESSION; ANXIETY; MODEL
AB Objective: Cardiometabolic disease (CMD) is a leading cause of death and disability worldwide. Assessments of psychological well-being taken at one time point are linked to reduced cardiometabolic risk, but psychological well-being may change over time and how longitudinal trajectories of psychological well-being may be related to CMD risk remains unclear. Furthermore, psychological well-being is a multidimensional construct comprised of distinct facets, but no work has examined whether sustaining high levels of multiple facets may confer additive protection. This study tested if trajectories of four psychological well-being facets would be associated with lower risk of self-reported nonfatal CMD. Method: Participants were 4,006 adults aged >= 50 years in the English Longitudinal study of Ageing followed for 18 years at biyearly intervals. Psychological well-being facets were measured in Waves 1-5 using subscales of the Control, Autonomy, Satisfaction, and Pleasure scale. Latent class growth modeling defined trajectories of each facet. Incident CMD cases were self-reported at Waves 6-9. Cox regression models estimated likelihood of incident CMD associated with trajectories of each facet individually and additively (i.e., having persistently high levels on multiple facets over time). Results: After adjusting for relevant covariates, CMD risk was lower for adults with persistently high versus persistently low levels of control and autonomy. When considering potential additive effects, lower CMD risk was also related to experiencing persistently high levels of >= 2 versus 0 psychological well-being facets. Conclusions: Findings suggest having and sustaining multiple facets of psychological well-being is beneficial for cardiometabolic health, and that effects may be additive.
C1 [Guimond, Anne-Josee; Trudel-Fitzgerald, Claudia; Qureshi, Farah; Kubzansky, Laura D.] Harvard TH Chan Sch Publ Hlth, Dept Social & Behav Sci, Boston, MA 02215 USA.
   [Guimond, Anne-Josee; Trudel-Fitzgerald, Claudia; Qureshi, Farah; Kubzansky, Laura D.] Harvard TH Chan Sch Publ Hlth, Lee Kum Sheung Ctr Hlth & Happiness, Boston, MA 02215 USA.
   [Boehm, Julia K.] Chapman Univ, Dept Psychol, Orange, CA USA.
C3 Harvard University; Harvard T.H. Chan School of Public Health; Harvard
   University; Harvard T.H. Chan School of Public Health; Chapman
   University System; Chapman University
RP Guimond, AJ (corresponding author), Harvard TH Chan Sch Publ Hlth, Landmark Ctr, Dept Social & Behav Sci, 401 Pk Dr,4th Floor, Boston, MA 02215 USA.
EM aguimond@hsph.harvard.edu
RI Guimond, Anne-JosÃ©e/ABG-8892-2020; Boehm, Julia/LJL-2745-2024
OI Trudel-Fitzgerald, Claudia/0000-0001-9989-4259; Boehm,
   Julia/0000-0001-8360-9935; Qureshi, Farah/0000-0002-9092-8085; Guimond,
   Anne-Josee/0000-0002-1690-6312
FU Canadian Institutes of Health Research
FX Anne-Josee Guimond was supported by salary and training support from the
   Canadian Institutes of Health Research (postdoctoral fellowship) and the
   Lee Kum Sheung Center for Health and Happiness. The authors have no
   conflicts of interest to disclose. Statistical support was provided by
   data science specialists Steven Worthington and Jinjie Liu, at the
   Institute for Quantitative Social Science, Harvard University, and by
   Sebastien Haneuse, Professor of Biostatistics at the Harvard T. H. Chan
   School of Public Health.
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NR 53
TC 5
Z9 5
U1 0
U2 34
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 0278-6133
EI 1930-7810
J9 HEALTH PSYCHOL
JI Health Psychol.
PD JAN
PY 2022
VL 41
IS 1
BP 32
EP 42
DI 10.1037/hea0001154
PG 11
WC Psychology, Clinical; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology
GA YR1PS
UT WOS:000749771200007
PM 35113584
DA 2025-06-11
ER

PT J
AU Li, MY
   Fang, QY
   Li, JZ
   Zheng, X
   Tao, J
   Yan, XH
   Lin, Q
   Lan, XL
   Chen, B
   Zheng, GH
   Chen, LD
AF Li, Moyi
   Fang, Qianying
   Li, Junzhe
   Zheng, Xin
   Tao, Jing
   Yan, Xinghui
   Lin, Qiu
   Lan, Xiulu
   Chen, Bai
   Zheng, Guohua
   Chen, Lidian
TI The Effect of Chinese Traditional Exercise-Baduanjin on Physical and
   Psychological Well-Being of College Students: A Randomized Controlled
   Trial
SO PLOS ONE
LA English
DT Article
ID METABOLIC SYNDROME; MENTAL-HEALTH; US; DISTRESS; QUALITY; FITNESS
AB Background
   The physical and mental health of college students tends to continuously decline around the world, therefore, it is important to improve their health during college period. Baduanjin, a traditional Chinese exercise which combines movements with breath and mind, may be one of the selectable effective exercises. However, the effect of Baduanjin exercise on college students has not been established. In this study, we systematically assessed the effectiveness and safety of Baduanjin exercise on physical and mental health of college students by a rigorous randomized, parallel-controlled design.
   Methods
   A total of 222 college students from Fujian University of Traditional Chinese Medicine were recruited and randomly allocated at an equal ratio into control or Baduanjin training. Participants in control group were informed to maintain their original activity habit, and those in Baduanjin exercise group received a 12-week Baduanjin exercise training with a frequency of 1 hour per day and 5 days per week on the basis of their original activity habit. The physical and psychological outcomes, including lumbar muscle strength, lower limb proprioception function, physical fitness, as well as self-reported symptom intensity, stress, self-esteem, mood, quality of life, quality of sleep, and adverse events, were evaluated at baseline, 13 weeks (at the end of 12-week intervention), and 25 weeks (after the 12-week follow-up period). Intention-to-treat analysis was performed for the above outcomes.
   Results
   Compared with controls, significant improvements in Baduanjin exercise group at the end of 12-week intervention period were found on lower limb proprioception function (the rate of average trace error on right lower limb (%): control 23.50 +/- 5.50, Baduanjin 21.92 +/- 6.54, P=0.004; the rate of average trace error on left lower limb (%): control 22.32 +/- 6.62, Baduanjin 20.63 +/- 4.62, P=0.046), cardiorespiratory endurance (step test index: control 47.66 +/- 5.94, Baduanjin 50.07 +/- 9.30, P=0.025), flexibility (control 14.35 +/- 7.26cm, Baduanjin 15.39 +/- 6.43cm, P=0.009) and explosive force of lower limb (standing long jump test (m): control 1.77 +/- 0.24, Baduanjin 1.79 +/- 0.22, P=0.005 for adjustment baseline) in physical outcomes, and attention (Schulte Grid test (second): control 210.4 +/- 51.15, Baduanjin 192.4 +/- 47.14, P=0.034) in mental outcome. Lumbar muscle strength in Baduanjin group had been moderately enhanced but no significant difference compared to controls. No significant changes in other physical and mental outcomes, including vital capacity, blood pressure, heart rate, hand grip force, self-symptom intensity, stress, self-efficacy, quality of life, and quality of sleep, were found between groups. No adverse event was reported during the study period.
   Conclusion
   Regular Baduanjin exercise had an advantage for college students on improvement of lower limb proprioception, enhance of cardiorespiratory endurance, flexibility, explosive force of lower limb and attention, compared with usual exercise.
C1 [Li, Moyi; Fang, Qianying; Li, Junzhe; Zheng, Xin; Tao, Jing; Lan, Xiulu; Chen, Bai; Zheng, Guohua] Fujian Univ Tradit Chinese Med, Coll Rehabil Med, Fuzhou, Fujian, Peoples R China.
   [Yan, Xinghui; Lin, Qiu] Fujian Univ Tradit Chinese Med, Dept Phys Educ, Fuzhou, Fujian, Peoples R China.
   [Chen, Lidian] Fujian Univ Tradit Chinese Med, Fuzhou, Fujian, Peoples R China.
C3 Fujian University of Traditional Chinese Medicine; Fujian University of
   Traditional Chinese Medicine; Fujian University of Traditional Chinese
   Medicine
RP Zheng, GH (corresponding author), Fujian Univ Tradit Chinese Med, Coll Rehabil Med, Fuzhou, Fujian, Peoples R China.
EM zhgh_1969@aliyun.com; lidianchen87@163.com
RI Zheng, Guo/E-8256-2013; Chen, Lidian/GSN-6461-2022; Tao,
   Jing/GVS-6340-2022
OI Chen, Lidian/0000-0002-8699-0839; Tao, Jing/0000-0002-4895-2065; Chen,
   Lidian/0000-0002-6454-7932; Tao, Jing/0000-0001-9751-5294
FU Rehabilitation Technology of Collaborative Innovation Center, FJTCM
   [X2012002-Collaboration]; Special Scientific Research Fund of Public
   Welfare Profession of China [201307004]; Ministry of Science and
   Technology; Ministry of Finance of the People's Republic of China
FX This study is funded by the Rehabilitation Technology of Collaborative
   Innovation Center, FJTCM (Grant No. X2012002-Collaboration), the Special
   Scientific Research Fund of Public Welfare Profession of China (Grant
   No. 201307004), Ministry of Science and Technology
   (http://www.most.gov.cn) and Ministry of Finance of the People's
   Republic of China (http://www.mof.gov.cn). The funders had no role in
   study design, data collection and analysis, decision to publish, or
   preparation of the manuscript.
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NR 54
TC 94
Z9 102
U1 11
U2 153
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JUL 9
PY 2015
VL 10
IS 7
AR e0130544
DI 10.1371/journal.pone.0130544
PG 16
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Science & Technology - Other Topics
GA CN1EW
UT WOS:000358161200013
PM 26158769
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU White, J
   Gray, RJ
   Swift, L
   Barton, GR
   Jones, M
AF White, Jacquie
   Gray, Richard J.
   Swift, Louise
   Barton, Garry R.
   Jones, Martin
TI The serious mental illness health improvement profile [HIP]: study
   protocol for a cluster randomised controlled trial
SO TRIALS
LA English
DT Article
ID CATIE SCHIZOPHRENIA TRIAL; WELL-BEING PROGRAM; PHYSICAL HEALTH;
   CARDIOVASCULAR RISK; METABOLIC SYNDROME; MANAGEMENT; INTERVENTION;
   STATEMENT; PEOPLE; IMPACT
AB Background: The serious mental illness Health Improvement Profile [HIP] is a brief pragmatic tool, which enables mental health nurses to work together with patients to screen physical health and take evidence-based action when variables are identified to be at risk. Piloting has demonstrated clinical utility and acceptability.
   Methods/Design: A single blind parallel group cluster randomised controlled trial with secondary economic analysis and process observation. Unit of randomisation: mental health nurses [MHNs] working in adult community mental health teams across two NHS Trusts. Subjects: Patients over 18 years with a diagnosis of schizophrenia, schizoaffective or bipolar disorder on the caseload of participating MHNs. Primary objective: To determine the effects of the HIP programme on patients' physical wellbeing assessed by the physical component score of the Medical Outcome Study (MOS) 36 Item Short Form Health Survey version 2 [SF-36v2]. Secondary objectives: To determine the effects of the HIP programme on: cost effectiveness, mental wellbeing, cardiovascular risk, physical health care attitudes and knowledge of MHNs and to determine the acceptability of the HIP Programme in the NHS. Consented nurses (and patients) will be randomised to receive the HIP Programme or treatment as usual. Outcomes will be measured at baseline and 12 months with a process observation after 12 months to include evaluation of patients' and professionals' experience and observation of any effect on care plans and primary-secondary care interface communication. Outcomes will be analysed on an intention-to-treat (ITT) basis.
   Discussion: The results of the trial and process observation will provide information about the effectiveness of the HIP Programme in supporting MHNs to address physical comorbidity in serious mental illness. Given the current unacceptable prevalence of physical comorbidity and mortality in the serious mental illness population, it is hoped the HIP trial will provide a timely contribution to evidence on organisation and delivery of care for patients, clinicians and policy makers.
C1 [White, Jacquie] Univ Hull, Fac Hlth & Social Care, Kingston Upon Hull HU6 7RX, N Humberside, England.
   [White, Jacquie; Barton, Garry R.] Univ E Anglia, Fac Hlth, Norwich NR4 7TJ, Norfolk, England.
   [Gray, Richard J.; Swift, Louise] Univ E Anglia, Fac Med & Hlth Sci, Norwich NR4 7TJ, Norfolk, England.
   [Jones, Martin] Univ Surrey, Guildford GU2 5XH, Surrey, England.
C3 University of Hull; University of East Anglia; University of East
   Anglia; University of Surrey
RP White, J (corresponding author), Univ Hull, Fac Hlth & Social Care, Kingston Upon Hull HU6 7RX, N Humberside, England.
EM jacqueline.white@hull.ac.uk
RI Jones, Martin/G-7810-2016; White, Jacquie/N-7287-2015; Gray,
   Richard/C-9945-2017
OI Jones, Martin/0000-0002-6463-3574; White, Jacquie/0000-0002-6196-2516;
   Gray, Richard/0000-0001-9694-4206
FU National Institute for Health Research [NIHR] [PB-PG-1208-18122];
   National Institutes of Health Research (NIHR) [PB-PG-1208-18122] Funding
   Source: National Institutes of Health Research (NIHR)
FX This paper presents independent research commissioned by the National
   Institute for Health Research [NIHR] under its Research for Patient
   benefit [RfPB] Programme (Grant Reference Number PB-PG-1208-18122). The
   views expressed are those of the authors and not necessarily those of
   the National Health Service, the NIHR or the Department of Health.
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NR 56
TC 17
Z9 17
U1 0
U2 26
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1745-6215
J9 TRIALS
JI Trials
PD JUL 4
PY 2011
VL 12
AR 167
DI 10.1186/1745-6215-12-167
PG 11
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Research & Experimental Medicine
GA 800WM
UT WOS:000293398400001
PM 21726440
OA Green Published, gold, Green Accepted
DA 2025-06-11
ER

PT J
AU Edward, KL
   Rasmussen, B
   Munro, I
AF Edward, Karen-leigh
   Rasmussen, Bodil
   Munro, Ian
TI Nursing Care of Clients Treated with Atypical Antipsychotics Who Have a
   Risk of Developing Metabolic Instability and/or Type 2 Diabetes
SO ARCHIVES OF PSYCHIATRIC NURSING
LA English
DT Article
ID BODY-MASS INDEX; SCHIZOPHRENIA-PATIENTS; BLOOD-GLUCOSE; HALOPERIDOL;
   RISPERIDONE; MEDICATION; OLANZAPINE; MELLITUS; BEHAVIOR; WEIGHT
AB Objective: The aim of this article is to present a current discussion related to the nursing care of clients treated with atypical antipsychotic medicines and who have a risk of developing metabolic instability and/or Type 2 diabetes. The importance of such a discussion is to provide both the novice and the experienced nurse with additional knowledge of this current health issue with which to inform their nursing practice.
   Discussion: The potential for psychosis to be a chronic condition is very high, and often people require antipsychotic medicine for lengthy periods throughout their lives. Sometimes, treatment is for life. The second generation of antipsychotic medicines was greeted with much enthusiasm since it was better tolerated than the first generation. However, each medication has desired and adverse effects and, when taken for lengthy periods, these effects may produce physical illness. Studies show that the prevalence of Type 2 diabetes and the metabolic syndrome was significantly higher in clients with a chronic psychiatric disorder, particularly schizophrenia.
   Conclusions: Metabolic instability, especially weight gain, is associated with some psychotropic medicines. Nursing interventions need to include care assessment, planning, intervention, and evaluation for clients treated with antipsychotic medicines in terms of risk minimization strategies in routine nursing care. (C) 2010 Elsevier Inc. All rights reserved.
C1 [Edward, Karen-leigh] Australian Catholic Univ, Ctr Nursing Res, Melbourne, Vic 3065, Australia.
   Deakin Univ, Sch Nursing, Melbourne, Vic, Australia.
   Monash Univ, Sch Nursing, Melbourne, Vic 3004, Australia.
C3 Australian Catholic University; Australian Catholic University -
   Melbourne Campus; Deakin University; Monash University
RP Edward, KL (corresponding author), Australian Catholic Univ, Ctr Nursing Res, POB 2900, Melbourne, Vic 3065, Australia.
RI Rasmussen, Bodil/M-7823-2015; Edward, Karen-leigh/H-3289-2014
OI Munro, Ian/0000-0002-3125-6952; Rasmussen, Bodil/0000-0002-6789-8260;
   Edward, Karen-leigh/0000-0001-8697-4006
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NR 39
TC 26
Z9 29
U1 0
U2 11
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0883-9417
EI 1532-8228
J9 ARCH PSYCHIAT NURS
JI Arch. Psychiatr. Nurs.
PD FEB
PY 2010
VL 24
IS 1
BP 46
EP 53
DI 10.1016/j.apnu.2009.04.009
PG 8
WC Nursing; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Psychiatry
GA 584FG
UT WOS:000276735700007
PM 20117688
DA 2025-06-11
ER

PT J
AU Skórkowska-Telichowska, K
   Kropielnicka, K
   Bulinska, K
   Pilch, U
   Wozniewski, M
   Szuba, A
   Jasinski, R
AF Skorkowska-Telichowska, Katarzyna
   Kropielnicka, Katarzyna
   Bulinska, Katarzyna
   Pilch, Urszula
   Wozniewski, Marek
   Szuba, Andrzej
   Jasinski, Ryszard
TI Nordic walking in the second half of life
SO AGING CLINICAL AND EXPERIMENTAL RESEARCH
LA English
DT Review
DE Physical rehabilitation; Elderly; Diseases of advanced age;
   Atherosclerosis; Metabolic syndrome; Parkinson's disease
ID RANDOMIZED-CONTROLLED-TRIAL; QUALITY-OF-LIFE; TYPE-2 DIABETES-MELLITUS;
   LOW-BACK-PAIN; PHYSIOLOGICAL-RESPONSES; PARKINSONS-DISEASE;
   ELDERLY-WOMEN; ENERGY-EXPENDITURE; HEART-FAILURE; EXERCISE
AB The objective of this article is to review the literature regarding the effectiveness and safety of Nordic walking (NW) in therapeutic rehabilitation in patients of an advanced age.
   Randomized studies comparing NW with different patterns of long-lasting physical rehabilitation in older adults (average age 65 years) were selected for the review. Studies were identified through a Medline database search covering the last 21 years.
   Seventy-four studies on this subject were identified, 37 of them fulfilled the required criteria and 27 of these were analyzed in this review.
   Nordic walking provides a safe and effective way to enhance physical activity in the elderly. It could also serve as a method of rehabilitation that improves fitness, the performance and the exercise capacity of aged persons with diseases associated with an advanced age: cardiovascular diseases due to atherosclerosis; metabolic syndrome without diabetes; early stage Parkinson's disease; chronic obstructive pulmonary disease and lowering depression in women with Sjogren's Syndrome.
C1 [Skorkowska-Telichowska, Katarzyna; Kropielnicka, Katarzyna; Bulinska, Katarzyna; Pilch, Urszula; Wozniewski, Marek; Szuba, Andrzej] Reg Specialist Hosp Wroclaw, WroVasc Integrated Med Cardiovasc Ctr, Ctr Res & Dev, H Kaminski 73a St, PL-51124 Wroclaw, Poland.
   [Kropielnicka, Katarzyna; Bulinska, Katarzyna; Pilch, Urszula; Wozniewski, Marek; Jasinski, Ryszard] Sch Phys Educ Wroclaw, Dept Rehabil, IJ Paderewski 35 St, PL-51612 Wroclaw, Poland.
   [Skorkowska-Telichowska, Katarzyna; Szuba, Andrzej] 4th Mil Hosp, Dept Internal Med, R Weigla 5 St, PL-50981 Wroclaw, Poland.
   [Skorkowska-Telichowska, Katarzyna; Szuba, Andrzej] Wroclaw Med Univ, Div Angiol, K Bartla 5 St, PL-51618 Wroclaw, Poland.
C3 Wroclaw Medical University
RP Skórkowska-Telichowska, K (corresponding author), Reg Specialist Hosp Wroclaw, WroVasc Integrated Med Cardiovasc Ctr, Ctr Res & Dev, H Kaminski 73a St, PL-51124 Wroclaw, Poland.; Skórkowska-Telichowska, K (corresponding author), 4th Mil Hosp, Dept Internal Med, R Weigla 5 St, PL-50981 Wroclaw, Poland.; Skórkowska-Telichowska, K (corresponding author), Wroclaw Med Univ, Div Angiol, K Bartla 5 St, PL-51618 Wroclaw, Poland.
EM cathcor@poczta.onet.pl
RI Szuba, Andrzej/AAY-1162-2020; Bulińska, Katarzyna/AEO-7051-2022;
   Jasinski, Ryszard/X-8643-2018
OI Szuba, Andrzej/0000-0002-7555-6201; Wozniewski,
   Marek/0000-0002-8241-7808; Bulinska, Katarzyna/0000-0002-4233-176X;
   Jasinski, Ryszard/0000-0002-0156-8074
FU European Regional Development Fund within the Innovative Economy
   Operational Program
FX This publication is part of Project "WroVasc-Integrated Cardiovascular
   Centre", co-financed by the European Regional Development Fund, within
   the Innovative Economy Operational Program, 2007-2013 realized in the
   Regional Specialist Hospital, Research and Development Center in
   Wroclaw.
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NR 41
TC 19
Z9 22
U1 1
U2 44
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1594-0667
EI 1720-8319
J9 AGING CLIN EXP RES
JI Aging Clin. Exp. Res.
PD DEC
PY 2016
VL 28
IS 6
BP 1035
EP 1046
DI 10.1007/s40520-016-0531-8
PG 12
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA EB7RW
UT WOS:000387588900001
PM 26803510
DA 2025-06-11
ER

PT J
AU Vladu, IM
   Cojan, TST
   Demetrian, A
   Cristea, OM
   Ene, CG
   Clenciu, D
AF Vladu, Ionela Mihaela
   Cojan, Tiberiu Stefanita Tenea
   Demetrian, Alin
   Cristea, Oana Mariana
   Ene, Cristina Gabriela
   Clenciu, Diana
TI The Presence of Chronic Kidney Disease in Relation to Age and Duration
   of Diabetes Mellitus
SO REVISTA DE CHIMIE
LA English
DT Article
DE Type 1 diabetes mellitus; chronic kidney
ID METABOLIC SYNDROME; RISK; STRESS
AB Chronic kidney disease (CKD) affects about 10-13% of the general population with a small proportion in the terminal renal disease stage requiring renal replacement therapy or renal transplantation. CKD is the new cause of mortaliOT in the US. CKD's prevalence increases with age. Diabetes mellitus is responsible for 50% of cases of chronic kidney disease being the most common cause.
C1 [Vladu, Ionela Mihaela; Clenciu, Diana] Univ Med & Pharm Craiova, Dept Metab & Nutr Dis, Filantropia Clin Hosp Craiova, 1 Filantropiei Str, Craiova 200143, Romania.
   [Cojan, Tiberiu Stefanita Tenea] Univ Med & Pharm Craiova, Dept Surg, CFR Hosp Craiova, Stirbei Voda Str, Craiova 200374, Romania.
   [Demetrian, Alin] Univ Med & Pharm Craiova, Dept Thorac Surg, Cty Hosp Craiova, 2-4 Petru Rares Str, Craiova 200349, Romania.
   [Cristea, Oana Mariana] Univ Med & Pharm Craiova, Dept Microbiol, Cty Hosp Craiova, 2-4 Petru Rares Str, Craiova 200349, Romania.
   [Ene, Cristina Gabriela] Univ Med & Pharm Craiova, Pharmacol Dept, Cty Hosp Craiova, 2-4 Petru Rares Str, Craiova 200349, Romania.
C3 University of Medicine & Pharmacy of Craiova; University of Medicine &
   Pharmacy of Craiova; University of Medicine & Pharmacy of Craiova;
   University of Medicine & Pharmacy of Craiova; University of Medicine &
   Pharmacy of Craiova
RP Cojan, TST (corresponding author), Univ Med & Pharm Craiova, Dept Surg, CFR Hosp Craiova, Stirbei Voda Str, Craiova 200374, Romania.
EM doctortts@yahoo.com
RI Vladu, Mihaela/AAA-6254-2021; Clenciu, Diana/AAA-6152-2021
OI Cristea, Oana Mariana/0000-0003-0869-6738; Clenciu,
   Diana/0000-0002-5832-0715; Vladu, Mihaela/0000-0002-6133-4341
CR [Anonymous], ANN INTERN MED
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NR 37
TC 1
Z9 1
U1 0
U2 14
PU REVISTA CHIMIE SRL
PI BUCURESTI
PA CALES PLEVNEI NR 139A, SECTOR 6, BUCURESTI, ROMANIA
SN 0034-7752
J9 REV CHIM-BUCHAREST
JI Rev. Chim.
PD APR
PY 2019
VL 70
IS 4
BP 1471
EP 1475
PG 5
WC Chemistry, Multidisciplinary; Engineering, Chemical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Engineering
GA IA2JK
UT WOS:000469387200076
DA 2025-06-11
ER

PT J
AU Estebanez, B
   Huang, CJ
   Rivera-Viloria, M
   Gonzalez-Gallego, J
   Cuevas, MJ
AF Estebanez, Brisamar
   Huang, Chun-Jung
   Rivera-Viloria, Marta
   Gonzalez-Gallego, Javier
   Cuevas, Maria J.
TI Exercise Outcomes in Childhood Obesity-Related Inflammation and
   Oxidative Status
SO FRONTIERS IN NUTRITION
LA English
DT Review
DE adipokines; antioxidant systems; cytokines; children; exercise;
   inflammation; oxidative stress; physical activity
ID CIRCULATING OXIDIZED-LDL; ADIPOSE-TISSUE; ENDOTHELIAL DYSFUNCTION;
   OVERWEIGHT CHILDREN; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   PHYSICAL-ACTIVITY; VISCERAL FAT; WEIGHT-LOSS; BODY-FAT
AB Childhood obesity is identified as one of the major public health issues to increase the risk for cardiometabolic diseases and related complications in adulthood. The literature has supported inflammation and oxidative stress as the primary underlying mechanisms involved in the pathogenesis of obesity-related diseases. Epidemiological evidence consistently shows the benefits of physical activity in the improvement of obesity-mediated inflammation and oxidative stress status. In this narrative mini-review, the available scientific evidence on the potential effects of exercise in alleviating these susceptibilities in childhood obesity will be assessed.
C1 [Estebanez, Brisamar; Rivera-Viloria, Marta; Gonzalez-Gallego, Javier; Cuevas, Maria J.] Univ Leon, Inst Biomed IBIOMED, Leon, Spain.
   [Huang, Chun-Jung] Florida Atlantic Univ, Dept Exercise Sci & Hlth Promot, Exercise Biochem Lab, Boca Raton, FL USA.
   [Gonzalez-Gallego, Javier] Ctr Invest Biomed Red Enfermedades Hepat & Digest, Madrid, Spain.
C3 Universidad de Leon; State University System of Florida; Florida
   Atlantic University; CIBER - Centro de Investigacion Biomedica en Red;
   CIBEREHD
RP Estebanez, B (corresponding author), Univ Leon, Inst Biomed IBIOMED, Leon, Spain.
EM b.estebanez@unileon.es
RI Gonzalez-Gallego, Javier/D-8219-2012; RIVERA VILORIA,
   MARTA/AEY-8301-2022; GONZÁLEZ, MARÍA/M-4927-2015; Estebanez,
   Brisamar/G-3863-2017
OI Estebanez, Brisamar/0000-0001-5034-9508; RIVERA VILORIA,
   MARTA/0000-0003-2109-1338; Gonzalez-Gallego, Javier/0000-0002-4386-9342
FU EXERNET Research Network on Physical Exercise and Health [09/UPB/19,
   45/UPB/20]; IN MOTU SALUS Research Network on Molecular and Cellular
   Basis of Physical Exercise for Health and Performance [14/UPB/19,
   09/UPB/20]
FX This project was supported by grants from the EXERNET Research Network
   on Physical Exercise and Health (09/UPB/19 and 45/UPB/20) and the IN
   MOTU SALUS Research Network on Molecular and Cellular Basis of Physical
   Exercise for Health and Performance (14/UPB/19 and 09/UPB/20).
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NR 81
TC 3
Z9 3
U1 2
U2 19
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD JUL 4
PY 2022
VL 9
AR 886291
DI 10.3389/fnut.2022.886291
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 3C0XQ
UT WOS:000828356000001
PM 35859754
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Diaz-Gerevini, GT
   Repossi, G
   Dain, A
   Tarres, MC
   Das, UN
   Eynard, AR
AF Diaz-Gerevini, G. T.
   Repossi, G.
   Dain, A.
   Tarres, M. C.
   Das, U. N.
   Eynard, A. R.
TI Cognitive and motor perturbations in elderly with longstanding diabetes
   mellitus
SO NUTRITION
LA English
DT Review
DE Diabetes mellitus; Insulin resistance; DE (Diabetic Encephalopathy);
   Oxidative stress; Dietary lipids
ID INSULIN-DEGRADING ENZYME; SEED PROANTHOCYANIDIN EXTRACTS;
   ANGIOTENSIN-ALDOSTERONE SYSTEM; POLYUNSATURATED FATTY-ACIDS; AMYLOID
   BETA-PROTEIN; OXIDATIVE STRESS; TAU PHOSPHORYLATION; INTRANASAL INSULIN;
   ALZHEIMERS-DISEASE; METABOLIC SYNDROME
AB Type 2 diabetes mellitus is a chronic disease characterized by insulin resistance; inflammation; oxidative stress; vascular damage; and dysfunction of glucose, protein, and lipid metabolisms. However, comparatively less attention has been paid to neurologic alterations seen in elderly individuals with type 2 diabetes. We review clinical, metabolic, and biochemical aspects of diabetic encephalopathy (DE) and propose that quality of dietary lipids is closely linked to DE. This implies that preventive nutritional interventions may be designed to improve DE. (C) 2014 Elsevier Inc. All rights reserved.
C1 [Diaz-Gerevini, G. T.; Repossi, G.; Dain, A.; Eynard, A. R.] Univ Nacl Cordoba, CONICET, Fac Ciencias Med, INICSA, RA-5000 Cordoba, Argentina.
   [Repossi, G.] Univ Nacl La Rioja, Catedra Histol Embriol & Genet, La Rioja, Argentina.
   [Repossi, G.; Tarres, M. C.; Eynard, A. R.] Consejo Nacl Invest Cient & Tecn, RA-1033 Buenos Aires, DF, Argentina.
   [Tarres, M. C.] Univ Nacl Rosario, Fac Ciencias Med, RA-2000 Rosario, Argentina.
   [Das, U. N.] GVP Hosp, Dept Med, Visakhapatnam, Andhra Pradesh, India.
   [Das, U. N.] BioSci Res Ctr, Visakhapatnam, Andhra Pradesh, India.
   [Das, U. N.] UND Life Sci, Washington, DC USA.
C3 Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET);
   National University of Cordoba; Consejo Nacional de Investigaciones
   Cientificas y Tecnicas (CONICET); National University of Rosario
RP Eynard, AR (corresponding author), Univ Nacl Cordoba, CONICET, Fac Ciencias Med, INICSA, RA-5000 Cordoba, Argentina.
EM Aeynard@gmail.com
RI Das, Undurti/A-7918-2009
OI Das, Undurti/0000-0002-0191-9508
FU PROMED of Ministerio de Educacion de la Nacion, Argentina; CONICET;
   SECYT-UNC; SECYT-UNLaR
FX GT Diaz-Gerevini and A. Dain are PhD students at Facultad de Ciencias
   Medicas, Universidad Nacional de Cordoba, Argentina. A. Dain is
   supported partially by a fellowship PROMED of Ministerio de Educacion de
   la Nacion, Argentina. This work was supported by funds provided by
   CONICET, SECYT-UNC, and SECYT-UNLaR.
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NR 117
TC 21
Z9 21
U1 1
U2 11
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0899-9007
EI 1873-1244
J9 NUTRITION
JI Nutrition
PD JUN
PY 2014
VL 30
IS 6
BP 628
EP 635
DI 10.1016/j.nut.2013.11.007
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA AH8WT
UT WOS:000336419600003
PM 24800665
OA Green Published
DA 2025-06-11
ER

PT J
AU Avogaro, A
   de Kreutzenberg, SV
   Fadini, G
AF Avogaro, Angelo
   de Kreutzenberg, Saula Vigili
   Fadini, GianPaolo
TI Endothelial dysfunction: Causes and consequences in patients with
   diabetes mellitus
SO DIABETES RESEARCH AND CLINICAL PRACTICE
LA English
DT Article
DE Diabetes; Endothelium; Oxidative stress; Endothelium progenitor cells
ID POSTPRANDIAL MYOCARDIAL-PERFUSION; INSULIN-RESISTANCE; OXIDATIVE STRESS;
   NITRIC-OXIDE; PROGENITOR CELLS; VASCULAR COMPLICATIONS;
   CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; BRACHIAL-ARTERY;
   RISK-FACTORS
AB Vascular endothelium plays a major role in maintaining cardiovascular homeostasis. Nitric oxide is the most powerful vasodilating compound. Diabetes disrupts endothelial integrity through an increased oxidative stress. Recent evidence indicates that there is a strong interaction between diabetes, the secretory proteins of adipocytes, called adipokines, and endothelium. Endothelial dysfunction may precede the development of overt DM, and a prolonged and repeated exposure to postprandial hyperglycemia may play an important role in the development of atherosclerosis, even in those who have normal fasting plasma glucose levels. (C) 2008 Published by Elsevier Ireland Ltd.
C1 [Avogaro, Angelo; de Kreutzenberg, Saula Vigili; Fadini, GianPaolo] Univ Padua, Sch Med, Dept Clin & Expt Med, Padua, Italy.
C3 University of Padua
RP Avogaro, A (corresponding author), Univ Padua Polyclin, Dipartimento Med Clin & Sperimentale Malattie Met, Via Giustiniani 2, I-35100 Padua, Italy.
EM angelo.avogaro@unipd.it
RI Fadini, Gian/M-4575-2019; Avogaro, Angelo/S-3808-2016
OI FADINI, GIAN PAOLO/0000-0002-6510-2097; AVOGARO,
   ANGELO/0000-0002-1177-0516
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NR 53
TC 69
Z9 80
U1 0
U2 11
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0168-8227
EI 1872-8227
J9 DIABETES RES CLIN PR
JI Diabetes Res. Clin. Pract.
PD DEC 15
PY 2008
VL 82
SU 2
BP S94
EP S101
DI 10.1016/j.diabres.2008.09.021
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 390CG
UT WOS:000262141300003
PM 18954919
DA 2025-06-11
ER

PT J
AU Patil, T
   Bernard, B
AF Patil, Tejas
   Bernard, Brandon
TI Complications of Androgen Deprivation Therapy in Men With Prostate
   Cancer
SO ONCOLOGY-NEW YORK
LA English
DT Article
ID RANDOMIZED CONTROLLED-TRIAL; QUALITY-OF-LIFE; COGNITIVE FUNCTION;
   JAPANESE PATIENTS; ZOLEDRONIC ACID; HOT FLASHES; BONE LOSS; RISK;
   BRACHYTHERAPY; GYNECOMASTIA
AB The standard treatment for men with metastatic prostate cancer is androgen deprivation therapy (ADT). This therapy is associated with a multitude of side effects that can impact quality of life. These include vasomotor complications (in particular, hot flushes), sexual dysfunction and gynecomastia, osteoporosis, metabolic syndrome, and depression. Additionally, ADT has been associated with neurocognitive deficits, thromboembolic disease, and cardiovascular disease, although the data regarding the latter associations are mixed. This article summarizes the key side effects associated with ADT and discusses strategies to optimize management.
C1 [Patil, Tejas] Univ Colorado, Sch Med, Hematol & Oncol Fellowship Program, Div Med Oncol, Aurora, CO 80045 USA.
   [Bernard, Brandon] Univ Colorado, Sch Med, Div Med Oncol, Aurora, CO USA.
C3 University of Colorado System; University of Colorado Anschutz Medical
   Campus; University of Colorado System; University of Colorado Anschutz
   Medical Campus
RP Patil, T (corresponding author), Univ Colorado, Sch Med, Hematol & Oncol Fellowship Program, Div Med Oncol, Aurora, CO 80045 USA.
RI Patil, Tejas/AEU-9465-2022
OI Patil, Tejas/0000-0003-4389-1010
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NR 46
TC 16
Z9 17
U1 0
U2 6
PU UBM MEDICA
PI NORWALK
PA 535 CONNECTICUT AVE, STE 300, NORWALK, CT 06854 USA
SN 0890-9091
J9 ONCOLOGY-NY
JI Oncology-NY
PD SEP
PY 2018
VL 32
IS 9
BP 470
EP 475
PG 6
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA GU1KJ
UT WOS:000445019500007
PM 30248169
DA 2025-06-11
ER

PT J
AU Ward, MC
   White, DT
   Druss, BG
AF Ward, Martha C.
   White, DeJuan T.
   Druss, Benjamin G.
TI A Meta-Review of Lifestyle Interventions for Cardiovascular Risk Factors
   in the General Medical Population: Lessons for Individuals With Serious
   Mental Illness
SO JOURNAL OF CLINICAL PSYCHIATRY
LA English
DT Review
ID IMPAIRED GLUCOSE-TOLERANCE; BLOOD-PRESSURE CONTROL; PHYSICAL-ACTIVITY;
   WEIGHT-LOSS; BEHAVIORAL INTERVENTIONS; MANAGEMENT; PEOPLE; PREVENTION;
   OBESITY; EXERCISE
AB Objective: Individuals with serious mental illness die years younger than members of the general population, with cardiovascular disease and related risk factors accounting for the majority of deaths. Lifestyle interventions targeting these risk factors have begun to be developed for those with serious mental illness, but they have largely been created de novo rather than with information from work already done in the general population. This review aims to synthesize for a mental health audience the common factors for success in nonpharmacologic lifestyle interventions and identify specific considerations in adapting these models for those with serious mental illness.
   Data Sources: We searched the PubMed and Cochrane databases for English-language reviews from 2003 to 2013. The search employed combinations of the following terms: diabetes, diabetes mellitus, hypertension, hyperlipidemia, dyslipidemia, obesity, mental illness, schizophrenia, psychosis, bipolar disorder, lifestyle intervention, nonpharmacologic intervention, lifestyle modification, and weight gain.
   Study Selection: We identified 8,147 review articles from the PubMed and Cochrane databases. 123 articles were selected. The selected articles were reviews of dietary, behavioral, or exercise interventions that focused on obesity and related cardiometabolic risk factors.
   Data Extraction: We undertook a qualitative "review of reviews" focusing on nonpharmacologic interventions for obesity and related cardiometabolic risk factors.
   Results: Effects of interventions in the general population were meaningful but generally modest. Specific elements of diet, exercise, and behavioral therapy produced larger effects. Additionally, successful programs employed multiple components, personalization, longer duration, more frequent contact, and trained treatment providers. Interventions addressing these risk factors in people with serious mental illness typically incorporated some, but not all, of the elements demonstrated to be effective in general medical populations.
   Conclusions: Studies from the general medical literature demonstrate considerable promise in addressing lifestyle risk factors. Existing programs will require tailoring to address the needs of those with serious mental illness and may be harder to implement given the challenges faced by this population. However, successful lifestyle interventions for those with serious mental illness can make a significant impact on the health and well-being of this vulnerable population and may inform future strategies for other underserved groups. (C) Copyright 2015 Physicians Postgraduate Press, Inc.
C1 [Ward, Martha C.; White, DeJuan T.] Emory Univ, Dept Gen Med, Dept Psychiat & Behav Sci, Rollins Sch Publ Hlth, Atlanta, GA 30303 USA.
   [Druss, Benjamin G.] Emory Univ, Dept Hlth Policy & Management, Rollins Sch Publ Hlth, Atlanta, GA 30303 USA.
C3 Emory University; Rollins School Public Health; Emory University;
   Rollins School Public Health
RP Ward, MC (corresponding author), Emory Univ, Dept Gen Med, Dept Psychiat & Behav Sci, 49 Jesse Hill Jr Dr SE,Ste 231, Atlanta, GA 30303 USA.
EM mcraig@emory.edu
RI White, DeJuan/GLU-4112-2022
FU Fitzgerald Foundation of Atlanta, Georgia; K24 award
FX Partial funding for this article was provided by a K24 award to Dr Druss
   and by a grant from the Fitzgerald Foundation of Atlanta, Georgia, to Dr
   Ward.
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NR 80
TC 84
Z9 85
U1 0
U2 28
PU PHYSICIANS POSTGRADUATE PRESS
PI MEMPHIS
PA P O BOX 752870, MEMPHIS, TN 38175-2870 USA
SN 0160-6689
EI 1555-2101
J9 J CLIN PSYCHIAT
JI J. Clin. Psychiatry
PD APR
PY 2015
VL 76
IS 4
BP E477
EP +
DI 10.4088/JCP.13r08657
PG 36
WC Psychology, Clinical; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA CI8DA
UT WOS:000354997500002
PM 25919840
DA 2025-06-11
ER

PT J
AU Carvajal, SC
   Huang, S
   Bell, ML
   Denman, C
   de Zapien, JG
   Cornejo, E
   Chang, J
   Staten, LK
   Rosales, C
AF Carvajal, S. C.
   Huang, S.
   Bell, M. L.
   Denman, C.
   de Zapien, J. Guernsey
   Cornejo, E.
   Chang, J.
   Staten, L. K.
   Rosales, C.
TI Behavioral and subjective health changes in US and Mexico border
   residing participants in two promotora-led chronic disease preventive
   interventions
SO HEALTH EDUCATION RESEARCH
LA English
DT Article
ID CARDIOMETABOLIC RISK; CARDIOVASCULAR RISK; PHYSICAL-ACTIVITY; COMMUNITY;
   WORKERS; CARE; REDUCTION; SALUD; AMERICANS; HISTORY
AB Chronic diseases are the primary health burden among Mexican-origin populations and health promotion efforts have not been able to change negative population trends. This research presents behavioral and subjective health impacts of two related community health worker (CHW) interventions conducted in the US-Mexico border region. Pasos Adelante (United States) and Meta Salud (Mexico) are 12-13 week CHW-led preventive interventions implemented with Mexico-origin adults. Curricula include active learning modules to promote healthy dietary changes and increasing physical activity; they also incorporate strategies to promote social support, empowerment and group exercise components responsive to their communities. Questionnaire data at baseline (N = 347 for Pasos; 171 for Meta Salud), program completion and 3-month follow-up were analyzed. Results showed statistically significant improvements in multiple reported dietary, physical activity and subjective health indicators. Furthermore, at follow-up across both cohorts there were >= 10% improvements in participants' meeting recommended physical activity guidelines, consumption of whole milk, days of poor mental health and self-rated health. While this study identifies some robust health improvements and contributes to the evidence base for these interventions current dissemination, the lack of change observed for some targeted behaviors (e.g. time sitting) suggests they may have stronger overall impacts with curricula refinement.
C1 [Carvajal, S. C.; de Zapien, J. Guernsey; Chang, J.] Univ Arizona, Mel & Enid Zuckerman Coll Publ Hlth, Hlth Promot Sci, 1295 N Martin Ave, Tucson, AZ 85724 USA.
   [Carvajal, S. C.] Univ Arizona, Mel & Enid Zuckerman Coll Publ Hlth, Arizona Prevent Res Ctr, 1295 N Martin Ave, Tucson, AZ 85724 USA.
   [Huang, S.; Bell, M. L.] Univ Arizona, Mel & Enid Zuckerman Coll Publ Hlth, Epidemiol & Biostat, 1295 N Martin Ave, Tucson, AZ 85724 USA.
   [Denman, C.; Cornejo, E.] El Colegio Sonora, Ctr Estudios Salud & Soc, Hermosillo, Sonora, Mexico.
   [Staten, L. K.] Indiana Univ, Richard M Fairbanks Sch Publ Hlth, Social & Behav Sci, 1050 Wishard Blvd,RG 6048, Indianapolis, IN 46202 USA.
   [Rosales, C.] Univ Arizona, Mel & Enid Zuckerman Coll Publ Hlth, Div Publ Hlth Practice & Translat Res, 714 E Van Buren St,Bldg 4,UA Phoenix Plaza 119G, Phoenix, AZ 85006 USA.
C3 University of Arizona; University of Arizona; University of Arizona;
   Indiana University System; Indiana University Indianapolis; University
   of Arizona
RP Carvajal, SC (corresponding author), Univ Arizona, Mel & Enid Zuckerman Coll Publ Hlth, Hlth Promot Sci, 1295 N Martin Ave, Tucson, AZ 85724 USA.; Carvajal, SC (corresponding author), Univ Arizona, Mel & Enid Zuckerman Coll Publ Hlth, Arizona Prevent Res Ctr, 1295 N Martin Ave, Tucson, AZ 85724 USA.
EM scott.carvajal@arizona.edu
RI ; Bell, Melanie/D-1839-2011
OI Staten, Lisa/0000-0002-6056-4153; Bell, Melanie/0000-0003-4821-4094
FU National Center for Chronic Disease Prevention and Health Promotion,
   Centers for Disease Control and Prevention, United States Department of
   Health and Human Services [U48DP005002, U48-DP000041]; UnitedHealth
   Chronic Disease Initiative; National Heart, Lung and Blood Institute,
   National Institutes of Health [R01HL125996]
FX This work was supported by the National Center for Chronic Disease
   Prevention and Health Promotion, Centers for Disease Control and
   Prevention, United States Department of Health and Human Services
   (U48DP005002 to S.C.C, U48-DP000041 to L.K.S.); UnitedHealth Chronic
   Disease Initiative (to C.D.) and the National Heart, Lung and Blood
   Institute, National Institutes of Health (R01HL125996 to C.R.).
CR [Anonymous], PAS AD CURR
   [Anonymous], ENC NAC SAL NUTR ENS
   [Anonymous], MET SAL
   [Anonymous], NOT ACC NUTR PHYS AC
   [Anonymous], NIH PUBLICATION
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NR 49
TC 4
Z9 4
U1 1
U2 11
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0268-1153
EI 1465-3648
J9 HEALTH EDUC RES
JI Health Educ. Res.
PD DEC
PY 2018
VL 33
IS 6
BP 522
EP 534
DI 10.1093/her/cyy037
PG 13
WC Education & Educational Research; Public, Environmental & Occupational
   Health
WE Social Science Citation Index (SSCI)
SC Education & Educational Research; Public, Environmental & Occupational
   Health
GA HI8EN
UT WOS:000456688200006
PM 30358830
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Jubaidi, FF
   Zainalabidin, S
   Taib, IS
   Abd Hamid, Z
   Budin, SB
AF Jubaidi, Fatin Farhana
   Zainalabidin, Satirah
   Taib, Izatus Shima
   Hamid, Zariyantey Abd
   Budin, Siti Balkis
TI The Potential Role of Flavonoids in Ameliorating Diabetic Cardiomyopathy
   via Alleviation of Cardiac Oxidative Stress, Inflammation and Apoptosis
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE diastolic dysfunction; flavone; flavonol; flavanol; isoflavone; systolic
   dysfunction
ID CARDIOMETABOLIC RISK-FACTORS; PROTEIN-KINASE-C; CELL-DEATH;
   DOUBLE-BLIND; MOLECULAR-MECHANISMS; INSULIN-RESISTANCE; HEART-FAILURE;
   RICH EXTRACT; IN-VITRO; HYPERTROPHY
AB Diabetic cardiomyopathy is one of the major mortality risk factors among diabetic patients worldwide. It has been established that most of the cardiac structural and functional alterations in the diabetic cardiomyopathy condition resulted from the hyperglycemia-induced persistent oxidative stress in the heart, resulting in the maladaptive responses of inflammation and apoptosis. Flavonoids, the most abundant phytochemical in plants, have been reported to exhibit diverse therapeutic potential in medicine and other biological activities. Flavonoids have been widely studied for their effects in protecting the heart against diabetes-induced cardiomyopathy. The potential of flavonoids in alleviating diabetic cardiomyopathy is mainly related with their remedial actions as anti-hyperglycemic, antioxidant, anti-inflammatory, and anti-apoptotic agents. In this review, we summarize the latest findings of flavonoid treatments on diabetic cardiomyopathy as well as elucidating the mechanisms involved.
C1 [Jubaidi, Fatin Farhana; Taib, Izatus Shima; Hamid, Zariyantey Abd; Budin, Siti Balkis] Univ Kebangsaan Malaysia, Ctr Diagnost Therapeut & Investigat Studies, Fac Hlth Sci, Kuala Lumpur 50300, Malaysia.
   [Zainalabidin, Satirah] Univ Kebangsaan Malaysia, Fac Hlth Sci, Ctr Toxicol & Hlth Risk Studies, Kuala Lumpur 50300, Malaysia.
C3 Universiti Kebangsaan Malaysia; Universiti Kebangsaan Malaysia
RP Budin, SB (corresponding author), Univ Kebangsaan Malaysia, Ctr Diagnost Therapeut & Investigat Studies, Fac Hlth Sci, Kuala Lumpur 50300, Malaysia.
EM fatinfarhanajubaidi@gmail.com; satirah@ukm.edu.my;
   izatusshima@ukm.edu.my; zyantey@ukm.edu.my; balkis@ukm.edu.my
RI Budin, Siti Balkis/ABB-8820-2021; Jubaidi, Fatin/G-7269-2016
OI Taib, Izatus Shima/0000-0001-9901-766X
FU Ministry of Education Malaysia [FRGS/1/2019/STG03/UKM/01/3]
FX This research was funded by the Ministry of Education Malaysia, grant
   number FRGS/1/2019/STG03/UKM/01/3.
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NR 140
TC 77
Z9 83
U1 0
U2 29
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD MAY
PY 2021
VL 22
IS 10
AR 5094
DI 10.3390/ijms22105094
PG 22
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA SS8QA
UT WOS:000662015900001
PM 34065781
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Brookheart, RT
   Duncan, JG
AF Brookheart, Rita T.
   Duncan, Jennifer G.
TI Drosophila melanogaster: An emerging model of
   transgenerational effects of maternal obesity
SO MOLECULAR AND CELLULAR ENDOCRINOLOGY
LA English
DT Article
DE Obesity; Drosophila; Diabetes; Mitochondria; Pregnancy; Nutritional
   programming
ID HIGH-FAT-DIET; ENDOPLASMIC-RETICULUM STRESS; GESTATIONAL WEIGHT-GAIN;
   BODY-MASS INDEX; HUMAN SKELETAL-MUSCLE; INSULIN-RESISTANCE;
   MITOCHONDRIAL DYSFUNCTION; CARDIOMETABOLIC RISK; GLUCOSE-HOMEOSTASIS;
   NUTRITIONAL-STATUS
AB The prevalence of obesity in the world is endemic with one rapidly growing health concern being maternal obesity. Obesity during pregnancy increases the risk of gestational diabetes, miscarriage, and preeclampsia, while rendering offspring susceptible to developmental anomalies and long-term metabolic complications including type 2 diabetes and cardiovascular disease. Several studies in humans and rodents demonstrate a correlation between the risks of maternal overnutrition and factors such as epigenetics, mitochondrial dysfunction, insulin resistance, ER stress, and immune system disruption. At present, the molecular mechanisms connecting these factors to maternal obesity are unknown. This review focuses on the use of Drosophila melanogaster to study human metabolic diseases, including obesity, and its emerging use to elucidate the mechanisms of maternal overnutrition and the impact on offspring. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
C1 [Brookheart, Rita T.; Duncan, Jennifer G.] Washington Univ, Sch Med, Dept Pediat, St Louis, MO 63110 USA.
C3 Washington University (WUSTL)
RP Duncan, JG (corresponding author), Washington Univ, Sch Med, 660 South Euclid Ave,Campus Box 8208, St Louis, MO 63110 USA.
EM duncan_j@wustl.edu
OI Brookheart, Rita/0000-0003-3247-3243
FU American Heart Association [IRG5450013, GRNT12080056, DRTC P30DK020579];
   National Institutes of Health [K12HD001459]
FX This work was supported by grants from the American Heart Association,
   IRG5450013 and GRNT12080056 (J.G.D), DRTC P30DK020579 (J.G.D) and the
   National Institutes of Health, K12HD001459 (R.T.B). The fly drawings in
   Figure 1 were generously provided by Leigh Zeidner.
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NR 118
TC 21
Z9 23
U1 0
U2 116
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0303-7207
EI 1872-8057
J9 MOL CELL ENDOCRINOL
JI Mol. Cell. Endocrinol.
PD NOV 5
PY 2016
VL 435
IS C
SI SI
BP 20
EP 28
DI 10.1016/j.mce.2015.12.003
PG 9
WC Cell Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Endocrinology & Metabolism
GA DW8YI
UT WOS:000383941000004
PM 26687062
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Cunha, FM
   da Silva, CCC
   Cerqueira, FM
   Kowaltowski, AJ
AF Cunha, Fernanda M.
   Caldeira da Silva, Camille C.
   Cerqueira, Fernanda M.
   Kowaltowski, Alicia J.
TI Mild Mitochondrial Uncoupling as a Therapeutic Strategy
SO CURRENT DRUG TARGETS
LA English
DT Review
DE Mitochondria; uncoupler; dinitrophenol; uncoupling protein; adenine
   nucleotide translocator; ATP-sensitive K+ channels
ID SENSITIVE K+-CHANNELS; SPARE RESPIRATORY CAPACITY; REACTIVE OXYGEN
   RELEASE; LIFE-SPAN; POTASSIUM CHANNEL; OXIDATIVE STRESS; CELL-DEATH;
   CALORIC RESTRICTION; OXIDANT STRESS; PROTON LEAK
AB Mild mitochondrial uncoupling, or the reduction of the efficiency of energy conversion without compromising intracellular high energy phosphate levels, is a protective therapeutic strategy under many laboratory conditions. Here we discuss these conditions, which include both cell and animal models of ischemia reperfusion and complications associated with the metabolic syndrome. We also discuss drugs that promote mild mitochondrial uncoupling and naturally occurring mild mitochondrial uncoupling pathways involving free fatty acid cycling and K+ transport.
C1 [Cunha, Fernanda M.; Caldeira da Silva, Camille C.; Cerqueira, Fernanda M.; Kowaltowski, Alicia J.] Univ Sao Paulo, Inst Quim, Dept Bioquim, BR-01498 Sao Paulo, Brazil.
C3 Universidade de Sao Paulo
RP Kowaltowski, AJ (corresponding author), Av Prof Lineu Prestes 748, BR-05508900 Sao Paulo, Brazil.
EM alicia@iq.usp.br
RI Kowaltowski, Alicia/H-8698-2012; cerqueira, fernanda/C-8326-2014;
   Marques da Cunha, Fernanda/G-3575-2012
OI Marques da Cunha, Fernanda/0000-0002-1583-5380
FU Fundacao de Amparo a Pesquisa no Estado de Sao Paulo (FAPESP); Conselho
   Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq); John Simon
   Guggenheim Memorial Foundation; Instituto Nacional de Ciencia e
   Tecnologia de Processos Redox em Biomedicina (Redoxoma)
FX This work is supported by Fundacao de Amparo a Pesquisa no Estado de Sao
   Paulo (FAPESP), Conselho Nacional de Desenvolvimento Cientifico e
   Tecnologico (CNPq), The John Simon Guggenheim Memorial Foundation and
   the Instituto Nacional de Ciencia e Tecnologia de Processos Redox em
   Biomedicina (Redoxoma). The authors thank Professor Vitor Ferreira for
   helpful discussions.
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NR 91
TC 72
Z9 75
U1 1
U2 34
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1389-4501
EI 1873-5592
J9 CURR DRUG TARGETS
JI Curr. Drug Targets
PD JUN
PY 2011
VL 12
IS 6
BP 783
EP 789
PG 7
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 777QW
UT WOS:000291640000004
PM 21275885
DA 2025-06-11
ER

PT J
AU Artero, EG
   Ferrez-Marquez, M
   Torrente-Sanchez, MJ
   Martínez-Rosales, E
   Carretero-Ruiz, A
   Hernandez-Martínez, A
   López-Sanchez, L
   Esteban-Simón, A
   del Rey, AR
   Alcaraz-Ibañez, M
   Rodríguez-Pérez, MA
   Villa-Gonzalez, E
   Barranco-Ruiz, Y
   Martínez-Forte, S
   Castillo, C
   Navarro, CG
   Cubero, JA
   Parrilla, RR
   Gómez, JAA
   Femia, P
   Fernandez-Alonso, AM
   Soriano-Maldonado, A
AF Artero, Enrique G.
   Ferrez-Marquez, Manuel
   Torrente-Sanchez, Maria Jose
   Martinez-Rosales, Elena
   Carretero-Ruiz, Alejandro
   Hernandez-Martinez, Alba
   Lopez-Sanchez, Laura
   Esteban-Simon, Alba
   Romero del Rey, Andrea
   Alcaraz-Ibanez, Manuel
   Rodriguez-Perez, Manuel A.
   Villa-Gonzalez, Emilio
   Barranco-Ruiz, Yaira
   Martinez-Forte, Sonia
   Castillo, Carlos
   Gomez Navarro, Carlos
   Aceituno Cubero, Jesus
   Reyes Parrilla, Raul
   Aparicio Gomez, Jose A.
   Femia, Pedro
   Fernandez-Alonso, Ana M.
   Soriano-Maldonado, Alberto
TI Supervised Exercise Immediately After Bariatric Surgery: the Study
   Protocol of the EFIBAR Randomized Controlled Trial
SO OBESITY SURGERY
LA English
DT Article
DE Obesity; Bariatric surgery; Exercise; Randomized controlled trial (RCT);
   Protocol
ID WEIGHT-LOSS; SPANISH VERSION; PHYSICAL-ACTIVITY; GASTRIC BYPASS;
   MENTAL-HEALTH; VALIDATION; RATIONALE; FITNESS; DESIGN; ADULTS
AB Background Previous studies have investigated weight loss caused by exercise following bariatric surgery. However, in most cases, the training program is poorly reported; the exercise type, volume, and intensity are briefly mentioned; and the sample size, selection criteria, and follow-up time vary greatly across studies.
   Purpose The EFIBAR study aims to investigate over 1 year the effects of a 16-week supervised exercise program, initiated immediately after bariatric surgery, on weight loss (primary outcome), body composition, cardiometabolic risk, physical fitness, and quality of life in patients with severe/extreme obesity.
   Material and Methods The EFIBAR study is a parallel-group, superiority, randomized controlled trial (RCT), comprising 80 surgery patients. Half of the participants, randomly selected, perform a 16-week supervised exercise program, including both strength and aerobic training, starting immediately after the surgery (7-14 days). For each participant, all primary and secondary outcomes are measured at three different time points: (i) before the surgery, (ii) after the intervention (approximate to 4 months), and (iii) 1 year after the surgery.
   Conclusion The EFIBAR study will provide new insights into the multidimensional benefits of exercise in adults with severe/extreme obesity following bariatric surgery.
C1 [Artero, Enrique G.; Martinez-Rosales, Elena; Carretero-Ruiz, Alejandro; Hernandez-Martinez, Alba; Lopez-Sanchez, Laura; Esteban-Simon, Alba; Rodriguez-Perez, Manuel A.; Soriano-Maldonado, Alberto] Univ Almeria, Dept Educ, Fac Educ Sci, SPORT Res Grp CTS 1024,CERNEP Res Ctr, Almeria, Spain.
   [Ferrez-Marquez, Manuel] Torrecardenas Univ Hosp, Gen & Bariatr Surg Unit, Almeria, Spain.
   [Ferrez-Marquez, Manuel; Torrente-Sanchez, Maria Jose] Hosp Mediterraneo, Almeria, Spain.
   [Romero del Rey, Andrea] Torrecardenas Univ Hosp, Pediat Unit, Almeria, Spain.
   [Alcaraz-Ibanez, Manuel] Univ Almeria, Dept Educ, Almeria, Spain.
   [Alcaraz-Ibanez, Manuel] Univ Almeria, Hlth Res Ctr, Almeria, Spain.
   [Villa-Gonzalez, Emilio; Barranco-Ruiz, Yaira] Univ Granada, PROFITH Promoting Fitness & Hlth Phys Act Res Grp, Dept Phys & Sports Educ, Fac Educ & Sport Sci,Sport & Hlth Univ Res Inst i, Melilla, Spain.
   [Martinez-Forte, Sonia; Fernandez-Alonso, Ana M.] Torrecardenas Univ Hosp, Obstet & Gynecol Unit, Almeria, Spain.
   [Castillo, Carlos] Univ Almeria, Dept Econ & Business, SPORT Res Grp CTS 1024, CERNEP Res Ctr, Almeria, Spain.
   [Gomez Navarro, Carlos; Aceituno Cubero, Jesus; Reyes Parrilla, Raul; Aparicio Gomez, Jose A.] Torrecardenas Univ Hosp, Unit Cardiol, Almeria, Spain.
   [Femia, Pedro] Univ Granada, Dept Stat & Operat Res, Fac Med, Granada, Spain.
C3 Universidad de Almeria; Universidad de Almeria; Universidad de Almeria;
   University of Granada; Universidad de Almeria; University of Granada
RP Artero, EG (corresponding author), Univ Almeria, Dept Educ, Fac Educ Sci, SPORT Res Grp CTS 1024,CERNEP Res Ctr, Almeria, Spain.
EM artero@ual.es
RI Femia, Pedro/C-1367-2011; Rodríguez-Pérez, Manuel/AAU-6670-2021;
   Martínez-Rosales, Elena/AAC-5236-2019; Castillo, Carlos/JJE-5679-2023;
   López-Sánchez, Laura/GNP-1938-2022; Alonso, Ana/Z-6241-2019;
   Esteban-Simón, Alba/AAS-5739-2021; Hernández-Martínez,
   Alba/AAC-7274-2019; Villa-González, Emilio/G-6421-2015; Barranco-Ruiz,
   Yaira/G-3007-2017; Artero, Enrique G./L-8628-2014; Soriano-Maldonado,
   Alberto/I-6379-2015; Alcaraz-Ibanez, Manuel/Z-2574-2019
OI Martinez-Rosales, Elena/0000-0002-8106-6823; Esteban-Simon,
   Alba/0000-0001-5296-4379; Artero, Enrique G./0000-0002-2618-6128;
   Soriano-Maldonado, Alberto/0000-0002-4626-420X; Femia,
   Pedro/0000-0002-1746-5619; Alcaraz-Ibanez, Manuel/0000-0002-1297-9565;
   Fernandez Alonso, Ana Maria/0000-0002-4844-2145; Lopez-Sanchez,
   Laura/0000-0001-5903-8327
FU Spanish Ministry of Economy and Competitiveness (MINECO), Plan Nacional
   de I+D+i calls RETOS [DEP2016-74926-R, RTI2018-093302-A-I00]; Spanish
   Ministry of Science, Innovation and Universities [FPU18/01107,
   FPU17/01158]; predoctoral fellowship program of the University of
   Almeria
FX This work was supported by the Spanish Ministry of Economy and
   Competitiveness (MINECO), Plan Nacional de I+D+i calls RETOS 2016
   (reference DEP2016-74926-R) and RETOS 2018 (reference
   RTI2018-093302-A-I00). EM-R and MAI were funded by the Spanish Ministry
   of Science, Innovation and Universities (FPU18/01107 and FPU17/01158,
   respectively). AH-M and LL-S were funded by the predoctoral fellowship
   program of the University of Almeria. The funding sources approved this
   study although they had no role in the design and will not have any role
   during its execution, analyses and interpretation of the data, writing
   manuscripts, or decision to submit for publication.
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NR 53
TC 4
Z9 4
U1 4
U2 12
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0960-8923
EI 1708-0428
J9 OBES SURG
JI Obes. Surg.
PD OCT
PY 2021
VL 31
IS 10
BP 4227
EP 4235
DI 10.1007/s11695-021-05559-8
EA JUL 2021
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA UW2OF
UT WOS:000673891200002
PM 34268680
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Roos, C
   Lidfeldt, J
   Agardh, CD
   Nyberg, P
   Nerbrand, C
   Samsioe, G
   Westrin, A
AF Roos, Camilla
   Lidfeldt, Jonas
   Agardh, Carl-David
   Nyberg, Per
   Nerbrand, Christina
   Samsioe, Goran
   Westrin, Asa
TI Insulin resistance and self-rated symptoms of depression in Swedish
   women with risk factors for diabetes: the Women's Health in the Lund
   Area study
SO METABOLISM-CLINICAL AND EXPERIMENTAL
LA English
DT Article
ID EXERCISE TREATMENT; HEART; BDNF
AB Previous studies have suggested that depression increases the risk for diabetes and that this may be mediated through insulin resistance. The study aimed to analyze if self-rated symptoms of depression are related to insulin resistance among middle-aged and older Swedish women with features of the metabolic syndrome and being at risk for type 2 diabetes mellitus. We analyzed data from 1047 Swedish women aged 50 to 64 years without a history of diabetes and living in the southern part of Sweden. A variable se f-ratedsyniptoms of depression (SRSD) was defined by using the Gothenburg Quality of Life instrument. We estimated odds ratios (ORs) to detennine whether or not SRSD was associated with the homeostasis model assessment of insulin resistance. The variable SRSD was not associated with insulin resistance. However, it was positively associated with waist-hip ratio (OR, 1.95; 95% confidence interval, 1.28-3.00) and negatively associated with physical exercise (OR, 1.29 - 95% confidence interval, 0.99-1.68) after multivariate adjustment. In conclusion, lifestyle factors such as physical inactivity and abdominal obesity, but not insulin resistance, seem to be related to ' self-rated symptoms of depression in women with risk factors for diabetes mellitus. The relationship between insulin resistance and major depression needs to be further examined. (c) 2007 Elsevier Inc. All rights reserved.
C1 Univ Lund Hosp, Dept Clin Sci, Div Psychiat, SE-22185 Lund, Sweden.
   Lund Univ, Malmo Univ Hosp, Dept Clin Sci, SE-20502 Malmo, Sweden.
   Lund Univ, Div Nursing, Dept Hlth Sci, SE-22100 Lund, Sweden.
C3 Lund University; Skane University Hospital; Lund University; Skane
   University Hospital; Lund University
RP Westrin, A (corresponding author), Univ Lund Hosp, Dept Clin Sci, Div Psychiat, SE-22185 Lund, Sweden.
EM asa.westrin@med.lu.se
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NR 25
TC 32
Z9 36
U1 0
U2 5
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0026-0495
EI 1532-8600
J9 METABOLISM
JI Metab.-Clin. Exp.
PD JUN
PY 2007
VL 56
IS 6
BP 825
EP 829
DI 10.1016/j.metabol.2007.01.013
PG 5
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 174BP
UT WOS:000246916500014
PM 17512316
DA 2025-06-11
ER

PT J
AU Fraser, SJ
   Brown, WJ
   Whiteford, HA
   Burton, NW
AF Fraser, Sarah J.
   Brown, Wendy J.
   Whiteford, Harvey A.
   Burton, Nicola W.
TI Impact of nurse-led behavioural counselling to improve metabolic health
   and physical activity among adults with mental illness
SO INTERNATIONAL JOURNAL OF MENTAL HEALTH NURSING
LA English
DT Article
DE adult; mental health; metabolic health; physical activity counselling
ID CARDIOMETABOLIC RISK-FACTORS; TO-HEIGHT RATIO; ANTIPSYCHOTIC
   MEDICATIONS; PEOPLE; DISORDERS; INTERVENTIONS; INDIVIDUALS; CARE;
   SCHIZOPHRENIA; AUSTRALIANS
AB The life expectancy of adults with mental illness is significantly less than that of the general population, and this is largely due to poor physical health. Behavioural counselling can improve physical health indicators among people with non-communicable disease. This repeated-measures, single-group intervention trial evaluated the effects of a 19-week behavioural counselling programme on metabolic health indicators and physical activity levels of outpatient adults with mental illness. Sixteen participants completed the intervention that comprised individual face-to-face counselling sessions with a registered nurse every 3weeks, and progress reviews with a medical practitioner every 6weeks. Assessment included self-report and objective measurement of physical activity, and measures of blood pressure and anthropometry. Statistically-significant changes were demonstrated between baseline and post intervention for participants' waist circumference (P=0.035) and waist-to-height ratio (P=0.037). Non-significant improvements were demonstrated in weight and physical activity. The findings indicated that adults with mental illness can engage in a nurse-led behavioural counselling intervention, with improvements in some metabolic health measures after 19weeks. It is recommended that behavioural counselling programmes for adults with mental illness be sustained over time and have an open door' policy to allow for attendance interruptions, such as hospitalization.
C1 [Fraser, Sarah J.; Brown, Wendy J.; Burton, Nicola W.] Univ Queensland, Sch Human Movement & Nutr Sci, Brisbane, Qld, Australia.
   [Whiteford, Harvey A.] Univ Queensland, Sch Publ Hlth, Brisbane, Qld, Australia.
C3 University of Queensland; University of Queensland
RP Fraser, SJ (corresponding author), Univ Queensland, Sch Human Movement & Nutr Sci, Level 5,Bldg 26B,Blair Dr, St Lucia, Qld 4072, Australia.
EM fraser.sarah17@gmail.com
RI Brown, Wendy/A-1553-2016; Whiteford, Harvey/A-4840-2009; Brown, Wendy
   J/G-2201-2010; Burton, Nicola/G-3313-2010
OI Whiteford, Harvey/0000-0003-4667-6623; Brown, Wendy
   J/0000-0001-9093-4509; Burton, Nicola/0000-0002-3221-2265; Fraser,
   Sarah/0000-0002-2602-0312
FU Toowong Private Hospital, Brisbane, Queensland, Australia
FX This study was supported by Toowong Private Hospital, Brisbane,
   Queensland, Australia, which provided gatekeeper approval to access
   their outpatient clinic.
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NR 40
TC 9
Z9 9
U1 0
U2 14
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1445-8330
EI 1447-0349
J9 INT J MENT HEALTH NU
JI Int. J. Ment. Health Nurs.
PD APR
PY 2018
VL 27
IS 2
BP 619
EP 630
DI 10.1111/inm.12343
PG 12
WC Nursing; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Psychiatry
GA GA5ZR
UT WOS:000428413100013
PM 28466504
DA 2025-06-11
ER

PT J
AU Huang, CH
   Huang, TJ
   Lin, YC
   Lin, CN
   Chen, MY
AF Huang, Cheng-Hsien
   Huang, Tung-Jung
   Lin, Yu-Chih
   Lin, Chia-Ni
   Chen, Mei-Yen
TI Factors Associated with Urinary 1-Hydroxypyrene and Malondialdehyde
   among Adults near a Petrochemical Factory: Implications for Sex and
   Lifestyle Modification
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Article
DE 1-hydroxypyrene (1-OHP); malondialdehyde (MDA); HBsAg (hepatitis B
   surface antigen); anti-HCV (hepatitis C virus); petrochemical industrial
   complex; health promotion
ID OXIDATIVE STRESS; EXPOSURE; POPULATION; SMOKE
AB Background: The association between the biomarkers of environmental exposure, oxidative stress, and health-related behaviors in community residents living in an endemic viral hepatitis area and near petrochemical industrial complexes remains unclear. From a health promotion perspective, healthcare providers must know what to do for residents concerned about their health and living environment, especially for individual-level and modifiable risk factors. Therefore, we aimed to explore the factors associated with urinary 1-hydroxypyrene (1-OHP) and malondialdehyde (MDA). Methods: A community-based, cross-sectional study was conducted between July 2018 and February 2019 in western coastal Yunlin County, Taiwan. All participants lived within a 10 km radius of a large petrochemical complex and did not work in the factory. This study was conducted with the local hospital through annual community health screening. Biological samples were collected and biomarkers determined and quantified in the central laboratory of the collaborating hospital. Results: A total of 6335 adult residents completed the study. The mean age was 47.7 (SD = 16) years. Out of the total population, 56.4% were female, 30.1% had metabolic syndrome (MetS), and 16.8% and 14.3% had hepatitis B virus antigen (HBsAg) and hepatitis C virus antibody (anti-HCV) positivity, respectively. The median 1-OHP and MDA level was 0.11 and 0.9 mu g/g creatinine with an interquartile range of 0.07-0.18, and 0.4-1.5, respectively. The MDA levels correlated with specific diseases. The multivariable ordinal logistic regression model revealed that female sex, smoking, betel nut use, HBsAg, and anti-HCV positivity were associated with higher 1-OHP levels. In men, MetS was associated with higher 1-OHP levels and regular exercise with lower 1-OHP levels. High MDA levels were associated with smoking, betel nut users, HBsAg, and anti-HCV positivity. Conclusions: The findings highlight the importance of initiating individualized health promotion programs for residents near petrochemical factories, especially for adults with substance-use and cardiometabolic risk factors. Furthermore, it is crucial to provide further treatment to patients with viral hepatitis.
C1 [Huang, Cheng-Hsien] Chang Gung Mem Hosp, Dept Family Med, Chiayi 613, Taiwan.
   [Huang, Tung-Jung] Chang Gung Mem Hosp, Dept Pulm Dis & Crit Care, Mailiao 638, Yunlin, Taiwan.
   [Huang, Tung-Jung] Chang Gung Univ Sci & Technol, Dept Resp Care, Chiayi 613, Taiwan.
   [Lin, Yu-Chih] Chang Gung Mem Hosp, Dept Family Med, Mailiao 638, Yunlin, Taiwan.
   [Lin, Chia-Ni] Chang Gung Mem Hosp, Dept Lab Med, Taoyuan 333, Taiwan.
   [Lin, Chia-Ni] Chang Gung Univ, Dept Med Biotechnol & Lab Sci, Taoyuan 333, Taiwan.
   [Chen, Mei-Yen] Chang Gung Univ Sci & Technol, Dept Nursing, Chiayi 613, Taiwan.
   [Chen, Mei-Yen] Chang Gung Univ, Sch Nursing, Taoyuan 333, Taiwan.
   [Chen, Mei-Yen] Chang Gung Mem Hosp, Dept Cardiol, Chiayi 613, Taiwan.
C3 Chang Gung Memorial Hospital; Chang Gung Memorial Hospital; Chang Gung
   University of Science & Technology; Chang Gung Memorial Hospital; Chang
   Gung Memorial Hospital; Chang Gung University; Chang Gung University of
   Science & Technology; Chang Gung University; Chang Gung Memorial
   Hospital
RP Chen, MY (corresponding author), Chang Gung Univ Sci & Technol, Dept Nursing, Chiayi 613, Taiwan.; Chen, MY (corresponding author), Chang Gung Univ, Sch Nursing, Taoyuan 333, Taiwan.; Chen, MY (corresponding author), Chang Gung Mem Hosp, Dept Cardiol, Chiayi 613, Taiwan.
EM shien36@cgmh.org.tw; donaldhuang@cgmh.org.tw; riverpig@cgmh.org.tw;
   chianilin@cgmh.org.tw; meiyen@mail.cgust.edu.tw
RI Chen, Kang-Hua/GLR-9451-2022
OI Chen, Mei-Yen/0000-0002-8980-1300; Lin, Yu-Chih/0000-0002-1190-406X;
   Lin, Chia-Ni/0000-0002-2722-0164
FU Taiwan Formosa Plastic Group (FCRP) [F6L0011]; Chang Gung Memorial
   Hospital [NMRPF6H0043]
FX The study was supported by a grant from Taiwan Formosa Plastic Group
   (FCRP F6L0011) and Chang Gung Memorial Hospital (NMRPF6H0043).
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NR 46
TC 0
Z9 0
U1 1
U2 5
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD FEB
PY 2022
VL 19
IS 3
AR 1362
DI 10.3390/ijerph19031362
PG 13
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA ZC2YL
UT WOS:000757391700001
PM 35162385
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Treloar, V
AF Treloar, Valori
TI Integrative dermatology for psoriasis: facts and controversies
SO CLINICS IN DERMATOLOGY
LA English
DT Article
ID BODY-MASS INDEX; METABOLIC SYNDROME; CLINICAL SEVERITY;
   CIGARETTE-SMOKING; NURSES HEALTH; RISK-FACTOR; TNF-ALPHA; FISH-OIL;
   STRESS; EXERCISE
AB Recommendations for changes in diet and lifestyle are not meant to supplant conventional therapy but to integrate with it and, hopefully, improve response to treatment. At the same time, integrative approaches permit the patient to depend less on more expensive and potentially harmful pharmaceutical and medical approaches. Manipulation of diet and lifestyle may actually diminish the effect of underlying predisposing or etiologic factors and simultaneously treat serious comorbidities. Topics include alcohol, smoking, body composition, sleep and stress, diet and nutrients, and exercise. (C) 2010 Published by Elsevier Inc.
C1 Integrat Dermatol, Newton, MA 02461 USA.
RP Treloar, V (corresponding author), Integrat Dermatol, 1172 Beacon St,Ste 402, Newton, MA 02461 USA.
EM trescon@rcn.com
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NR 56
TC 12
Z9 12
U1 0
U2 10
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0738-081X
EI 1879-1131
J9 CLIN DERMATOL
JI Clin. Dermatol.
PD JAN-FEB
PY 2010
VL 28
IS 1
BP 93
EP 99
DI 10.1016/j.clindermatol.2009.03.016
PG 7
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 619JB
UT WOS:000279425300018
PM 20082958
DA 2025-06-11
ER

PT J
AU Masuda, H
   Sato, A
   Miyata, K
   Shizuno, T
   Oyamada, A
   Ishiwata, K
   Nakagawa, Y
   Asahara, T
AF Masuda, Haruchika
   Sato, Atsuko
   Miyata, Kumiko
   Shizuno, Tomoko
   Oyamada, Akira
   Ishiwata, Kazuo
   Nakagawa, Yoshihiro
   Asahara, Takayuki
TI Drinking Molecular Hydrogen Water Is Beneficial to Cardiovascular
   Function in Diet-Induced Obesity Mice
SO BIOLOGY-BASEL
LA English
DT Article
DE obesity; molecular hydrogen; brown adipose tissue; white adipose tissue;
   cardiovascular disorders; metabolic syndrome
ID BROWN ADIPOSE-TISSUE; RICH WATER; METABOLIC SYNDROME; ENERGY-METABOLISM;
   GENE-EXPRESSION; ANTIOXIDANT; INJURY; CELLS; MOUSE; REPERFUSION
AB Simple Summary
   Molecular hydrogen (MH) reportedly exerts therapeutic effects against inflammatory diseases by alleviating oxidative stress. We investigated the cardiovascular protective effects of molecular hydrogen water (MHW) intake using high-fat diet-induced obesity (DIO) mice. We observed that MHW intake for 2 weeks did not improve the blood sugar level or body weight but decreased heart weight in DIO mice. Notably, MHW intake alleviated oxidative stress in both the heart and the adipose tissue. Moreover, it improved cardiac hypertrophy and restored left ventricular function in DIO mice, and promoted the histological conversion of energy storage to expenditure in adipose tissues with the upregulation of thermogenic and cardiovascular protective genes. Furthermore, MHW restored endothelial progenitor cell (EPC) bioactivity to maintain vascular homeostasis. Taken together, MHW intake exerts cardiovascular protective effects in DIO mice. Hence, MHW intake is a potential prophylactic strategy against cardiovascular disorders in metabolic syndrome.
   Molecular hydrogen (MH) reportedly exerts therapeutic effects against inflammatory diseases as a suppressor of free radical chain reactions. Here, the cardiovascular protective effects of the intake of molecular hydrogen water (MHW) were investigated using high-fat diet-induced obesity (DIO) mice. MHW was prepared using supplier sticks and degassed water as control. MHW intake for 2 weeks did not improve blood sugar or body weight but decreased heart weight in DIO mice. Moreover, MHW intake improved cardiac hypertrophy, shortened the width of cardiomyocytes, dilated the capillaries and arterioles, activated myocardial eNOS-Ser-1177 phosphorylation, and restored left ventricular function in DIO mice. MHW intake promoted the histological conversion of hypertrophy to hyperplasia in white and brown adipose tissues (WAT and BAT) with the upregulation of thermogenic and cardiovascular protective genes in BAT (i.e., Ucp-1, Vegf-a, and eNos). Furthermore, the results of a colony formation assay of bone-marrow-derived endothelial progenitor cells (EPCs) indicated that MHW activated the expansion, differentiation, and mobilization of EPCs to maintain vascular homeostasis. These findings indicate that the intake of MHW exerts cardiovascular protective effects in DIO mice. Hence, drinking MHW is a potential prophylactic strategy against cardiovascular disorders in metabolic syndrome.
C1 [Masuda, Haruchika; Sato, Atsuko; Miyata, Kumiko; Shizuno, Tomoko; Ishiwata, Kazuo] Tokai Univ, Sch Med, Dept Physiol, 143 Shimokasuya, Isehara, Kanagawa 2591193, Japan.
   [Oyamada, Akira; Asahara, Takayuki] Tokai Univ, Sch Med, Dept Innovat Med Sci, 143 Shimokasuya, Isehara, Kanagawa 2591193, Japan.
   [Nakagawa, Yoshihiro] Tokai Univ, Sch Med, Dept Opthalmol, 143 Shimokasuya, Isehara, Kanagawa 2591193, Japan.
C3 Tokai University; Tokai University; Tokai University
RP Masuda, H (corresponding author), Tokai Univ, Sch Med, Dept Physiol, 143 Shimokasuya, Isehara, Kanagawa 2591193, Japan.
EM masu3510@is.icc.u-tokai.ac.jp; asato@tsc.u-tokai.ac.jp;
   miyata.kumiko@tsc.u-tokai.ac.jp; shizuno@tsc.u-tokai.ac.jp;
   a.oya.lab@gmail.com; ishiwata@jeff.co.jp; nakayosi@is.icc.u-tokai.ac.jp;
   asa777@is.icc.u-tokai.ac.jp
FU Tokai Univ. School of Medicine Research Aid; Tokai University General
   Research Organization Grant
FX This work was supported by Tokai Univ. School of Medicine Research Aid
   for H.M., and Tokai University General Research Organization Grant.
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NR 52
TC 5
Z9 6
U1 0
U2 11
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2079-7737
J9 BIOLOGY-BASEL
JI Biology-Basel
PD MAY
PY 2021
VL 10
IS 5
AR 364
DI 10.3390/biology10050364
PG 18
WC Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics
GA SG4JF
UT WOS:000653406600001
PM 33922704
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Stamu-O'Brien, C
   Kroumpouzos, G
AF Stamu-O'Brien, Caroline
   Kroumpouzos, George
TI The role of lipids in vitiligo and schizophrenia
SO CLINICS IN DERMATOLOGY
LA English
DT Article
ID ADJUNCTIVE THERAPY; OXIDATIVE STRESS; FATTY-ACIDS; STATINS;
   PATHOGENESIS; CHOLESTEROL; METABOLISM; DISORDERS; DISEASE; CELLS
AB The pathogenesis of vitiligo and schizophrenia has not been adequately clarified. We explore the role of lipids in these diseases. Both conditions have been associated with stress in several observations and studies. Research data indicate complex interactions between oxidative stress and metabolic syndrome-with lipid abnormalities being a significant component of the latter-in these diseases. The impaired membrane lipid homeostasis mechanism is related to the increased phospholipid remodeling caused by excessive oxidative stress in schizophrenia. We indicate that sphingomyelin is possibly involved in the pathogenesis of these diseases. Statins have anti-inflammatory and immunomodulating effects and an effect against oxidative stress. Preliminary clinical studies show that these agents may be beneficial in both vitiligo and schizophrenia, but their therapeutic value should be studied further. (c) 2023 Elsevier Inc. All rights reserved.
C1 [Stamu-O'Brien, Caroline] NYU, Sch Med, Dept Psychiat, New York, NY USA.
   [Kroumpouzos, George] Brown Univ, Warren Alpert Med Sch, Dept Dermatol, Providence, RI 02912 USA.
C3 New York University; Brown University
RP Kroumpouzos, G (corresponding author), Brown Univ, Warren Alpert Med Sch, Dept Dermatol, Providence, RI 02912 USA.
EM gk@gkderm.com
RI Stamu-O'Brien, Caroline/AAX-3745-2021; Kroumpouzos, George/P-1301-2015
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NR 51
TC 4
Z9 4
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0738-081X
EI 1879-1131
J9 CLIN DERMATOL
JI Clin. Dermatol.
PD JAN-FEB
PY 2023
VL 41
IS 1
BP 89
EP 94
DI 10.1016/j.clindermatol.2023.03.007
EA JUL 2023
PG 6
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA M9JI0
UT WOS:001033298400001
PM 36878451
DA 2025-06-11
ER

PT J
AU Wu, YY
   Li, SS
   Han, D
   Zhang, M
   Zhao, J
   Liao, H
   Ma, Y
   Yan, CY
   Wang, J
AF Wu, Yunyi
   Li, Sangsang
   Han, Dan
   Zhang, Mei
   Zhao, Jie
   Liao, Hui
   Ma, Ying
   Yan, Chaoyang
   Wang, Jing
TI The Mediating Role of Depression in Association Between Total Sleep Time
   and Instrumental Activities of Daily Living in China
SO INTERNATIONAL JOURNAL OF PUBLIC HEALTH
LA English
DT Article
DE total sleep time; IADL disability; depression; gender difference; panel
   data
ID GENDER-DIFFERENCES; OLDER-ADULTS; FUNCTIONAL DISABILITY; COGNITIVE
   FUNCTION; METABOLIC SYNDROME; PHYSICAL FUNCTION; GLOBAL BURDEN;
   DURATION; SYMPTOMS; HEALTH
AB Objectives: This study aims to investigate the mediating role of depression and the moderating effect of gender in the relationship between total sleep time (TST) and instrumental activities of daily living (IADL) in middle-aged and elderly people (aged 45 or above).Methods: The data used in this study is from the China Health and Retirement Longitudinal Study (CHARLS), including a total of 10,460 respondents. Associations between TST, IADL, depression, and gender were analyzed using logistic regression and Karlson, Holm, and Breen (KHB) methods.Results: Short (OR = 1.42, 95% CI = 1.28-1.58 of <= 6 h) and long TST (OR = 1.16, 95% CI = 1.02-1.32 of 8-9 h; OR = 1.35, 95% CI = 1.19-1.54 of >9 h) were both associated with IADL. The mediation effect analyses observed that depression explained 64.80% of the total effect of short TST (<= 6 h) and IADL, but was insignificant in long TST (8-9 h and >9 h). Meanwhile, gender has moderating effects on the mediation effect model.Conclusion: The study suggests that health interventions that focused on the dimensions of TST and depression are crucial for preventing functional disability while accounting for gender differences.
C1 [Wu, Yunyi; Li, Sangsang; Han, Dan; Zhang, Mei; Zhao, Jie; Liao, Hui; Ma, Ying; Yan, Chaoyang; Wang, Jing] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Med & Hlth Management, Dept Hlth Management, Wuhan, Peoples R China.
   [Wang, Jing] Huazhong Univ Sci & Technol, Key Res Inst Humanities & Social Sci Hubei Prov, Wuhan, Peoples R China.
   [Wang, Jing] Huazhong Univ Sci & Technol, Inst Poverty Reduct & Dev, Wuhan, Peoples R China.
C3 Huazhong University of Science & Technology; Huazhong University of
   Science & Technology; Huazhong University of Science & Technology
RP Wang, J (corresponding author), Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Med & Hlth Management, Dept Hlth Management, Wuhan, Peoples R China.; Wang, J (corresponding author), Huazhong Univ Sci & Technol, Key Res Inst Humanities & Social Sci Hubei Prov, Wuhan, Peoples R China.; Wang, J (corresponding author), Huazhong Univ Sci & Technol, Inst Poverty Reduct & Dev, Wuhan, Peoples R China.
EM jingwang@hust.edu.cn
RI Liao, Hui/IQU-4142-2023; Ding, Hu/KAM-6579-2024; Yan,
   Chaoyang/GXG-4324-2022
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NR 63
TC 7
Z9 7
U1 7
U2 47
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1661-8556
EI 1661-8564
J9 INT J PUBLIC HEALTH
JI Int. J. Public Health
PD APR 4
PY 2023
VL 68
AR 1605678
DI 10.3389/ijph.2023.1605678
PG 10
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA D5UQ4
UT WOS:000969386200001
PM 37081904
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Abdelkarem, HM
   Fadda, LH
AF Abdelkarem, Hala M.
   Fadda, Lila H.
TI Flaxseed and quercetin improve anti-inflammatory cytokine level and
   insulin sensitivity in animal model of metabolic syndrome, the
   fructose-fed rats
SO ARABIAN JOURNAL OF CHEMISTRY
LA English
DT Article
DE Metabolic syndrome; Leptin; Adiponectin; High fructose diet; Insulin and
   diabetes
ID CORONARY-HEART-DISEASE; NECROSIS-FACTOR-ALPHA; OXIDATIVE STRESS;
   GENE-EXPRESSION; ADIPOSE-TISSUE; SECOISOLARICIRESINOL DIGLUCOSIDE;
   ADIPONECTIN EXPRESSION; FLAVONOID QUERCETIN; RISK-FACTORS; IN-VIVO
AB The purpose of this study is to assess the beneficial effect of quercetin, flaxseed and/or in combination as synergetic in an animal model of metabolic syndrome (MtS), high fructose (HF)-fed rats. Fifty male Sprague-Dawley rats, 3-month old and weighing between 110 and 120 g were randomly divided into 2 groups. Rats were given drinking water (-ve control rats) or 10% fructose in drinking water (HF; fructose-fed rats) with standard chow for 8 weeks. After 4 weeks of fructose feeding, HF-fed rats were further divided into matched 4 subgroups. Different groups of animals (n - 10, each group) were administered; 10% HF (5 mg/kg, +ve control), flaxseed (F; 50 mg/kg), quercetin (Q; 50 mg/kg), flaxseed + quercetin, (FQ; 25 mg/kg of each), respectively. All ingredients were given orally once daily and subsequent 4 weeks. Serum glucose, insulin, lipids profile, leptin, and adiponectin were estimated. After 4 weeks of feeding, a significant increase in blood glucose level was observed in HF fed rats compared to normal rats, but this increase was significantly decreased after administration of F, Q and FQ. The raised serum insulin level in HF fed rats was significantly decreased after administration of F and FQ groups. Significantly higher concentrations of triacylglycerols (TG), total cholesterol and low density lipoprotein cholesterol (LDL-C) were observed in HF fed rats and these increases were lower after administration of F, Q and FQ. There was a significant increase in serum high density lipoprotein cholesterol (HDL-C) in the FQ group. The increased serum leptin level was decreased significantly in F, Q and FQ groups. Whereas the reduction of serum adiponectin level in HF fed rats was increased in F, Q and FQ groups. These data suggested that protective effect of flaxseed and quercetin consumption as functional foods could reduce risk for people with decreased insulin sensitivity and increased oxidative stress, such as those with the metabolic syndrome or type 2 diabetes. (C) 2013 King Saud University. Production and hosting by Elsevier B.V.
C1 [Abdelkarem, Hala M.] Al Jouf Univ, Biochem Dept, Sci Coll, Jouf, Saudi Arabia.
   King Saud Univ, Pharmacol Dept, Pharm Coll, Riyadh, Saudi Arabia.
   Natl Res Ctr, Human Nutr Dept, Cairo, Egypt.
C3 Al Jouf University; King Saud University; Egyptian Knowledge Bank (EKB);
   National Research Centre (NRC)
RP Abdelkarem, HM (corresponding author), Al Jouf Univ, Biochem Dept, Sci Coll, Jouf, Saudi Arabia.
EM halaabdelkarem@yahoo.com
RI Abdelkarem, Hala/AAH-7001-2021
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NR 46
TC 8
Z9 9
U1 0
U2 8
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1878-5352
EI 1878-5379
J9 ARAB J CHEM
JI Arab. J. Chem.
PD MAY
PY 2017
VL 10
SU 2
BP S3015
EP S3020
DI 10.1016/j.arabjc.2013.11.042
PG 6
WC Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry
GA FR2LG
UT WOS:000418897900086
OA gold
DA 2025-06-11
ER

PT J
AU Faulconbridge, LF
   Driscoll, CFB
   Hopkins, CM
   Benforado, BB
   Bishop-Gilyard, C
   Carvajal, R
   Berkowitz, RI
   DeRubeis, R
   Wadden, TA
AF Faulconbridge, Lucy F.
   Driscoll, Colleen F. B.
   Hopkins, Christina M.
   Benforado, Brooke Bailer
   Bishop-Gilyard, Chanelle
   Carvajal, Raymond
   Berkowitz, Robert I.
   DeRubeis, Robert
   Wadden, Thomas A.
TI Combined Treatment for Obesity and Depression: A Pilot Study
SO OBESITY
LA English
DT Article
ID RANDOMIZED CONTROLLED-TRIAL; LIFE-STYLE INTERVENTION; WEIGHT-LOSS;
   CARDIOVASCULAR RISK; METABOLIC SYNDROME; COMORBID OBESITY;
   HEART-DISEASE; UNITED-STATES; WOMEN; INDIVIDUALS
AB ObjectiveObesity and depression frequently co-occur, and each increases risk for cardiovascular disease (CVD). This study tested whether a combined treatment, targeting obesity and depression simultaneously, would yield greater improvements in weight, mood, and CVD risk factors than treatments that targeted each disease individually.
   MethodsSeventy-six participants with obesity and major depression were randomly assigned to (1) behavioral weight control (BWC), (2) cognitive behavioral therapy for depression (CBT-D), or (3) BWC combined with CBT-D. Participants were provided 18 group treatment sessions over 20 weeks. Mood, weight, and CVD risk were assessed at baseline and weeks 8 and 20, with a follow-up visit at week 46.
   ResultsAt week 20, participants in combined treatment lost significantly (P<0.02) more weight (5.2%1.2%) than those assigned to CBT-D (0.8%+/- 1.3%) and comparable amounts as those in BWC (3.5%+/- 1.3%). Depression scores decreased significantly from baseline levels in each group, with no significant differences between groups. All three groups showed significant improvements in 10-year CVD risk, with no significant differences between groups. Groups did not differ significantly on any of these measures at week 46.
   ConclusionsBWC yielded short-term improvements in weight, mood, and CVD risk, comparable to a combined treatment that incorporated CBT-D. Results require replication with a larger sample size.
C1 [Faulconbridge, Lucy F.; Driscoll, Colleen F. B.; Hopkins, Christina M.; Benforado, Brooke Bailer; Bishop-Gilyard, Chanelle; Carvajal, Raymond; Berkowitz, Robert I.; DeRubeis, Robert; Wadden, Thomas A.] Univ Penn, Dept Psychiat, Perelman Sch Med, Philadelphia, PA 19104 USA.
   [Berkowitz, Robert I.] Childrens Hosp Philadelphia, Dept Psychiat, Philadelphia, PA 19104 USA.
   [DeRubeis, Robert] Univ Penn, Dept Psychol, 3815 Walnut St, Philadelphia, PA 19104 USA.
C3 University of Pennsylvania; University of Pennsylvania; Pennsylvania
   Medicine; Childrens Hospital of Philadelphia; University of Pennsylvania
RP Faulconbridge, LF (corresponding author), Univ Penn, Dept Psychiat, Perelman Sch Med, Philadelphia, PA 19104 USA.
EM lucyhf@pennmedicine.upenn.edu
RI Driscoll, Colleen/KXR-7384-2024; DeRubeis, Robert/A-1049-2007; Cobden,
   David/AGL-5940-2022
OI Hopkins, Christina/0000-0003-4660-6641; Wadden,
   Thomas/0000-0002-0438-4609
FU Mentored Patient-Oriented Research Career Development Award (K23) from
   National Heart, Blood, and Lung Institute [K23-HL109235]
FX This research was supported by a Mentored Patient-Oriented Research
   Career Development Award (K23) to LFF from the National Heart, Blood,
   and Lung Institute (K23-HL109235).
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NR 40
TC 34
Z9 35
U1 0
U2 8
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1930-7381
EI 1930-739X
J9 OBESITY
JI Obesity
PD JUL
PY 2018
VL 26
IS 7
BP 1144
EP 1152
DI 10.1002/oby.22209
PG 9
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA GK2HV
UT WOS:000435949600009
PM 29932516
DA 2025-06-11
ER

PT J
AU Canan, F
   Yildirim, O
   Tosun, M
   Kayka, N
   Tuman, TC
   Alcelik, A
AF Canan, Fatih
   Yildirim, Osman
   Tosun, Mehmet
   Kayka, Nefise
   Tuman, Taha Can
   Alcelik, Aytekin
TI SERUM LEVELS OF OMENTIN ARE NOT ALTERED IN DRUG-NAIVE PATIENTS WITH
   MAJOR DEPRESSION: A PILOT STUDY
SO PSYCHIATRIA DANUBINA
LA English
DT Article
DE adipokines; major depression; omentin
ID METABOLIC SYNDROME; PLASMA-LEVELS; ADIPOKINES; LEPTIN; ASSOCIATION;
   ADIPONECTIN; RISK; ADULTS; INFLAMMATION; PREVALENCE
AB Background: Decreased plasma levels of omentin, a relatively novel adipokine, are shown to be associated with metabolic abnormalities and proinflammatory states. Although other adipokines such as leptin and adiponectin have been extensively investigated in patients with major depressive disorder (MDD), no studies have evaluated omentin levels in major depression. Therefore, this study sought to test the hypothesis that drug-naive patients with MDD would have lower serum omentin levels than a healthy control group similar in age, sex, and body mass index.
   Subjects and methods: Thirty patients with MDD (10 men) and 30 healthy control subjects (10 men) were studied. Plasma concentration of omentin, along with other biochemical parameters, was measured after a period of fasting. The severity of depression was determined by the Beck Depression Inventory.
   Results: No significant difference was found between patients with MDD (723.3 +/- 233.8 ng/ml) and healthy comparison subjects (670.7 +/- 351.8 ng/ml) in mean plasma concentrations of omentin (p>0.05). There was no significant correlation between plasma omentin levels and depression severity (r=-0.147; p>0.05).
   Conclusions: This is the first investigation of omentin levels in patients with MDD. The hypothesis that circulating omentin levels would be different in depressed patients than in healthy controls is not supported by our data.
C1 [Canan, Fatih] Akdeniz Univ Sch Med, Dept Psychiat, TR-07059 Antalya, Turkey.
   [Yildirim, Osman; Kayka, Nefise; Tuman, Taha Can] Abant Izzet Baysal Univ Sch Med, Dept Psychiat, Bolu, Turkey.
   [Tosun, Mehmet] Abant Izzet Baysal Univ Sch Med, Dept Med Biochem, Bolu, Turkey.
   [Alcelik, Aytekin] Abant Izzet Baysal Univ Sch Med, Dept Internal Med, Bolu, Turkey.
C3 Akdeniz University; Abant Izzet Baysal University; Abant Izzet Baysal
   University; Abant Izzet Baysal University
RP Canan, F (corresponding author), Akdeniz Univ Sch Med, Dept Psychiat, TR-07059 Antalya, Turkey.
EM faithcanan@gmail.com
RI Canan, Fatih/C-1622-2016; TUMAN, TAHA/AAZ-5054-2020; Alcelik,
   Aytekin/B-4621-2015
OI Alcelik, Aytekin/0000-0002-3156-1076
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NR 39
TC 5
Z9 8
U1 0
U2 4
PU MEDICINSKA NAKLADA
PI ZAGREB
PA VLASKA 69, HR-10000 ZAGREB, CROATIA
SN 0353-5053
J9 PSYCHIAT DANUB
JI Psychiatr. Danub.
PY 2014
VL 26
IS 1
BP 34
EP 38
PG 5
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA AK7UE
UT WOS:000338632400005
PM 24608150
DA 2025-06-11
ER

PT J
AU Sestito, A
   Maccallini, A
   Sgueglia, GA
   Infusino, F
   Larosa, C
   Aurigemma, C
   Crea, F
   Lanza, GA
AF Sestito, A
   Maccallini, A
   Sgueglia, GA
   Infusino, F
   Larosa, C
   Aurigemma, C
   Crea, F
   Lanza, GA
TI Platelet reactivity in response to mental stress in syndrome X and in
   stable or unstable coronary artery disease
SO THROMBOSIS RESEARCH
LA English
DT Article
DE platelet reactivity; mental stress test; syndrome X; stable angina;
   unstable angina
ID CARDIAC SYNDROME-X; MYOCARDIAL-ISCHEMIA; STRENUOUS EXERCISE; MODERATE
   EXERCISE; ANGINA-PECTORIS; AGGREGABILITY; ACTIVATION; AGGREGATION;
   VASOMOTION; FLOW
AB Introduction: Previous studies showed differences in reactivity in response to exercise in patients with syndrome X (SX) and those with obstructive coronary artery disease (CAD). In this study, we investigated whether similar differences could be detectable in response to a mental stressful stimulus.
   Materials and methods: We studied 30 SX patients (60 +/- 8 years, 8 men), 20 patients with stable angina and angiographically documented CAD (SA, 66 +/- 8 years, 14 men), and 11 patients with unstable angina (UA, 67 +/- 8 years, 6 men). A control group of 22 healthy controls (50 +/- 7 years, 5 men) was also studied. All subjects underwent a mathematical mental stress test (MST) consisting of rapid consecutive subtractions of number 7 for a period of 5 min. A venous blood sample was collected at baseline and immediately after MST Platelet reactivity was measured on flowing blood as time necessary to occlude a ring coated with collagen-adenosine diphosphate (ADP; closure time, CT), using the platelet function analyzer (PFA-100) system.
   Results: At rest, CT was lower in UA patients (87 +/- 19 s) compared to controls (109 +/- 24 s, p=0.02) and SA patients (105 +/- 37 s, p=0.055), and also tended to be lower in SX patients (96 +/- 18 s) compared to controls (p=0.07). The CT response to MST differed significantly among groups (p=0.0009). At peak MST, CT did not change in controls (110 +/- 27 s, p=0.88), whereas it decreased in SA patients (96 +/- 29 s, p=0.003) and tended to decrease in UA patients (82 +/- 15 s, p=0.25). In contrast, a significant increase in CT with MST was shown in SX patients (103 +/- 21 s, p=0.007).
   Conclusions Platelet reactivity is increased by MST in patients with CAD, whereas it paradoxically decreases in SX patients, which may constitute a protective effect against stress-induced events in these patients. (c) 2004 Elsevier Ltd. All rights reserved.
C1 Univ Cattolica S Cuore, Ist Cardiol, I-00168 Rome, Italy.
C3 Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli
RP Univ Cattolica S Cuore, Ist Cardiol, Lgo A Gemelli 8, I-00168 Rome, Italy.
EM g.a.lanza@inwind.it
RI Crea, Filippo/AAC-9754-2022; Larosa, Claudio/AAW-4457-2020; Aurigemma,
   Cristina/J-9958-2018; Lanza, Gaetano/AAC-2660-2019; Sgueglia,
   Gregory/A-9701-2019; Infusino, Fabio/JEF-6750-2023; BURZOTTA,
   FRANCESCO/K-1004-2018
OI Sgueglia, Gregory/0000-0001-9680-7412; Aurigemma,
   Cristina/0000-0001-6391-422X; Infusino, Fabio/0000-0001-9287-5936;
   BURZOTTA, FRANCESCO/0000-0002-6569-9401
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NR 31
TC 16
Z9 19
U1 0
U2 0
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0049-3848
J9 THROMB RES
JI Thromb. Res.
PY 2005
VL 116
IS 1
BP 25
EP 31
DI 10.1016/j.thromres.2004.10.002
PG 7
WC Hematology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Hematology; Cardiovascular System & Cardiology
GA 927DZ
UT WOS:000229173900003
PM 15850605
DA 2025-06-11
ER

PT J
AU Han, S
   Liang, CP
   DeVries-Seimon, T
   Ranalletta, M
   Welch, CL
   Collins-Fletcher, K
   Accili, D
   Tabas, I
   Tall, AR
AF Han, S
   Liang, CP
   DeVries-Seimon, T
   Ranalletta, M
   Welch, CL
   Collins-Fletcher, K
   Accili, D
   Tabas, I
   Tall, AR
TI Macrophage insulin receptor deficiency increases ER stress-induced
   apoptosis and necrotic core formation in advanced atherosclerotic
   lesions
SO CELL METABOLISM
LA English
DT Article
ID ENDOPLASMIC-RETICULUM STRESS; CELL-DEATH; SCAVENGER RECEPTOR; SIGNALING
   PATHWAY; OXIDATIVE STRESS; GROWTH-FACTOR; ACTIVATION; CHOLESTEROL; MICE;
   RESISTANCE
AB Insulin resistance in diabetes and metabolic syndrome is thought to increase susceptibility to atherosclerotic cardiovascular disease, but the underlying mechanisms are poorly understood. To evaluate the possibility that decreased insulin signaling in macrophage foam cells might worsen atherosclerosis, Ldlr(-/-) mice were transplanted with insulin receptor Insr(+/+) or Insr(-/-) bone marrow. Western diet-fed Insr(-/-) recipients developed larger, more complex lesions with increased necrotic cores and increased numbers of apoptotic cells. Insr(-/-) macrophages showed diminished Akt phosphorylation and an augmented ER stress response, leading to induction of scavenger receptor A and increased apoptosis when challenged with cholesterol loading or nutrient deprivation. These studies suggest that defective insulin signaling and reduced Akt activity impair the ability of macrophages to deal with ER stress-induced apoptosis within atherosclerotic plaques.
C1 Columbia Univ, Dept Med Anat & Cell Biol, New York, NY 10032 USA.
   Columbia Univ, Dept Physiol & Cellular Biophys, New York, NY 10032 USA.
C3 Columbia University; Columbia University
RP Columbia Univ, Dept Med Anat & Cell Biol, New York, NY 10032 USA.
EM sh2068@columbia.edu; c1534@columbia.edu
RI Tall, Alan/AAT-8528-2021
OI Seimon, Tracie/0000-0003-3658-1364; Tabas, Ira/0000-0003-3429-1515
CR Accili D, 2004, CELL, V117, P421, DOI 10.1016/S0092-8674(04)00452-0
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NR 46
TC 234
Z9 262
U1 0
U2 11
PU CELL PRESS
PI CAMBRIDGE
PA 50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA
SN 1550-4131
EI 1932-7420
J9 CELL METAB
JI Cell Metab.
PD APR
PY 2006
VL 3
IS 4
BP 257
EP 266
DI 10.1016/j.cmet.2006.02.008
PG 10
WC Cell Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Endocrinology & Metabolism
GA 031GJ
UT WOS:000236692300006
PM 16581003
OA Bronze
DA 2025-06-11
ER

PT J
AU Roshanravan, N
   Shabestari, AN
   Alamdari, NM
   Ostadrahimi, A
   Separham, A
   Parvizi, R
   Jafarabadi, MA
   Ghodrat, M
   Akbarzadeh, M
   Naemi, M
   Ghazi, MKK
   Hadi, A
   Ghaffari, S
AF Roshanravan, Neda
   Shabestari, Alireza Namazi
   Alamdari, Naimeh Mesri
   Ostadrahimi, Alireza
   Separham, Ahmad
   Parvizi, Rezayat
   Jafarabadi, Mohammad Asghari
   Ghodrat, Mahshid
   Akbarzadeh, Moloud
   Naemi, Mohammad
   Ghazi, Mahdiyeh Khabbaz Koche
   Hadi, Amir
   Ghaffari, Samad
TI A novel inflammatory signaling pathway in patients with slow coronary
   flow: NF-κB/IL-1β/nitric oxide
SO CYTOKINE
LA English
DT Article
DE Slow coronary flow; Metabolic syndrome; Inflammation; Nitric oxide;
   NF-kappa B; IL-1 beta
ID TIMI FRAME COUNT; NF-KAPPA-B; NITRIC-OXIDE; INSULIN-RESISTANCE;
   METABOLIC SYNDROME; ASSOCIATION; RATIO; THROMBOLYSIS; EXPRESSION;
   ARTERIES
AB Purpose: The slow coronary flow (SCF) was identified as delayed opacification of epicardial coronary arteries in the absence of stenotic lesion. Metabolic syndrome (MetS), oxidative stress, and inflammation may be possible known insulting factors for the pathogenesis of SCF. This investigation aimed to assess the relationship between some inflammatory markers, oxidative stress parameters and MetS components with SCF phenomenon.
   Methods: A total of 35 patients with SCF and 35 subjects with normal coronary flow (NCF) were included in the study. We assessed some inflammatory markers (IL-1 beta, IL-18, TNF-alpha, and NF-kappa B mRNA expression in peripheral blood mononuclear cells (PBMCs)). Moreover, blood samples of the participants were tested for total antioxidant capacity (TAC), glutathione peroxidase (GPX) and nitric oxide (NO) levels using enzyme-linked immunosorbent assay (ELISA). Diagnosis of MetS was based on the National Cholesterol Education Program's Adult Treatment Panel III report (ATPIII) criteria, 2005. Diagnostic criteria for coronary flow rates of all subjects were documented by thrombolysis in myocardial infarction (TIMI) frame count method.
   Results: SCF patients had significantly higher prevalence of MetS (46%, p = 0.048).We found that the level of TAC was significantly higher in the NCF group (p = 0.006). Furthermore, the NO concentration was significantly lower in SCF groups (p = 0.001). A significant incremental difference was detected in IL-1 beta (fold change 2.82 +/- 0.31, p < 0.05) and NF-kappa B (fold change 4.62 +/- 0.32, p < 0.05) mRNA expression in the SCF group when compared with its level in the NCF group. Furthermore, according to logistic regression analysis, there were significant associations between IL-1 beta, NF-kappa B expression levels and the incidence of SCF (p < 0.05).
   Conclusion: Based on the findings of this study, the pathogenesis of the SCF phenomenon may be closely associated with metabolic syndrome and inflammation. The NF-kappa B/IL-1 beta/nitric oxide & MetS signaling pathway might be considered as potential therapeutic targets in the management of SCF patients but further researches is required to guarantee these findings.
C1 [Roshanravan, Neda; Separham, Ahmad; Parvizi, Rezayat; Ghodrat, Mahshid; Akbarzadeh, Moloud; Ghaffari, Samad] Tabriz Univ Med Sci, Cardiovasc Res Ctr, Tabriz 5166615573, Iran.
   [Shabestari, Alireza Namazi] Univ Tehran Med Sci, Sch Med, Dept Geriatr Med, Tehran, Iran.
   [Alamdari, Naimeh Mesri] Iran Univ Med Sci, Sch Hlth, Students Res Comm, Tehran, Iran.
   [Ostadrahimi, Alireza; Naemi, Mohammad; Ghazi, Mahdiyeh Khabbaz Koche] Tabriz Univ Med Sci, Nutr Res Ctr, Tabriz, Iran.
   [Jafarabadi, Mohammad Asghari] Tabriz Univ Med Sci, Rd Traff Injury Res Ctr, Tabriz, Iran.
   [Akbarzadeh, Moloud] Tabriz Univ Med Sci, Stem Cell & Regenerat Med Inst, Tabriz, Iran.
   [Hadi, Amir] Isfahan Univ Med Sci, Food Secur Res Ctr, Sch Nutr & Food Sci, Dept Clin Nutr, Esfahan, Iran.
C3 Tabriz University of Medical Science; Tehran University of Medical
   Sciences; Iran University of Medical Sciences; Tabriz University of
   Medical Science; Tabriz University of Medical Science; Tabriz University
   of Medical Science; Isfahan University of Medical Sciences
RP Ghaffari, S (corresponding author), Tabriz Univ Med Sci, Cardiovasc Res Ctr, Tabriz 5166615573, Iran.
EM ghafaris@gmail.com
RI parvizi, rezayat/M-2889-2017; Hadi, Amir/AAK-4634-2020; akbarzadeh,
   moloud/HRE-3483-2023; Asghari Jafarabadi, Mohammmad/A-7478-2017;
   Separham, Ahmad/L-9475-2017
OI Asghari Jafarabadi, Mohammmad/0000-0003-3284-9749; Mesri Alamdari,
   Naimeh/0000-0003-2563-8193; Separham, Ahmad/0000-0001-7011-9507
FU Research Vice Chancellor, Tabriz University of Medical Sciences
FX This work was supported by the Research Vice Chancellor, Tabriz
   University of Medical Sciences.
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NR 43
TC 16
Z9 16
U1 0
U2 16
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 1043-4666
EI 1096-0023
J9 CYTOKINE
JI Cytokine
PD JUL
PY 2021
VL 143
AR 155511
DI 10.1016/j.cyto.2021.155511
EA MAY 2021
PG 7
WC Biochemistry & Molecular Biology; Cell Biology; Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology; Immunology
GA RZ5OG
UT WOS:000648645700006
PM 33839001
DA 2025-06-11
ER

PT J
AU McIntosh, RC
   Lobo, J
   Paparozzi, J
   Goodman, Z
   Kornfeld, S
   Nomi, J
AF McIntosh, Roger C.
   Lobo, Judith
   Paparozzi, Jeremy
   Goodman, Zach
   Kornfeld, Salome
   Nomi, Jason
TI Neutrophil to lymphocyte ratio is a transdiagnostic biomarker of
   depression and structural and functional brain alterations in older
   adults
SO JOURNAL OF NEUROIMMUNOLOGY
LA English
DT Article
DE Neutrophilia; Lymphocytopenia; Geriatric depression; Resting state
   functional connectivity; Medial frontal cortex; Perigenual anterior
   cingulate
ID C-REACTIVE PROTEIN; MEDIAL PREFRONTAL CORTEX; HUMAN CINGULATE CORTEX;
   INFLAMMATORY MARKERS; TNF-ALPHA; HYPOTHALAMIC INFLAMMATION;
   PLATELET-LYMPHOCYTE; METABOLIC SYNDROME; SICKNESS BEHAVIOR;
   GENE-EXPRESSION
AB The neutrophil to lymphocyte ratio (N:L) is an emergent transdiagnostic biomarker shown to predict peripheral inflammation as well as neuropsychiatric impairment. The afferent signaling of inflammation to the central nervous system has been implicated in the pathophysiology of sickness behavior and depression. Here, the N:L was compared to structural and functional limbic alterations found concomitant with depression within a geriatric cohort. Venous blood was collected for a complete blood count, and magnetic resonance imaging as well as phenotypic data were collected from the 66 community-dwelling older adults (aged 65-86 years). The N:L was regressed on gray matter volume and resting-state functional connectivity (rsFC) of the subgenual anterior cingulate (sgACC). Thresholded parameter estimates were extracted from structural and functional brain scans and bivariate associations tested with scores on the geriatric depression scale. Greater N:L predicted lower volume of hypothalamus and rsFC of sgACC with ventromedial prefrontal cortex. Both parameters were corre-lated (p < 0.05) with greater symptomology in those reporting moderate to severe levels of depression. These findings support the N:L as a transdiagnostic biomarker of limbic alteration underpinning mood disturbance in non-treated older adults.
C1 [McIntosh, Roger C.; Lobo, Judith; Paparozzi, Jeremy; Goodman, Zach; Kornfeld, Salome; Nomi, Jason] Univ Miami, Dept Psychol, Coral Gables, FL 33124 USA.
C3 University of Miami
RP McIntosh, RC (corresponding author), Univ Miami, Dept Psychol, Coral Gables, FL 33124 USA.
EM r.mcintosh@miami.edu
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NR 101
TC 6
Z9 6
U1 0
U2 13
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-5728
EI 1872-8421
J9 J NEUROIMMUNOL
JI J. Neuroimmunol.
PD APR 15
PY 2022
VL 365
AR 577831
DI 10.1016/j.jneuroim.2022.577831
EA FEB 2022
PG 7
WC Immunology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Immunology; Neurosciences & Neurology
GA 0V1RL
UT WOS:000788122500006
PM 35217366
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Walrabenstein, W
   van der Leeden, M
   Weijs, P
   van Middendorp, H
   Wagenaar, C
   van Dongen, JM
   Nieuwdorp, M
   de Jonge, CS
   van Boheemen, L
   van Schaardenburg, D
AF Walrabenstein, Wendy
   van der Leeden, Marike
   Weijs, Peter
   van Middendorp, Henriet
   Wagenaar, Carlijn
   van Dongen, Johanna Maria
   Nieuwdorp, Max
   de Jonge, Catharina Sophia
   van Boheemen, Laurette
   van Schaardenburg, Dirkjan
TI The effect of a multidisciplinary lifestyle program for patients with
   rheumatoid arthritis, an increased risk for rheumatoid arthritis or with
   metabolic syndrome-associated osteoarthritis: the "Plants for Joints"
   randomized controlled trial protocol
SO TRIALS
LA English
DT Article
ID DISEASE-ACTIVITY; KNEE OSTEOARTHRITIS; AMERICAN-COLLEGE; VEGETARIAN
   DIET; OBESE ADULTS; WEIGHT-LOSS; EXERCISE; CLASSIFICATION; INFLAMMATION;
   OVERWEIGHT
AB Low-grade inflammation and metabolic syndrome are seen in many chronic diseases, including rheumatoid arthritis (RA) and osteoarthritis (OA). Lifestyle interventions which combine different non-pharmacological therapies have shown synergizing effects in improving outcomes in patients with other chronic diseases or increased risk thereof, especially cardiovascular disease. For RA and metabolic syndrome-associated OA (MSOA), whole food plant-based diets (WFPDs) have shown promising results. A WFPD, however, had not yet been combined with other lifestyle interventions for RA and OA patients. In this protocol paper, we therefore present Plants for Joints, a multidisciplinary lifestyle program, based on a WFPD, exercise, and stress management. The objective is to study the effect of this program on disease activity in patients with RA (randomized controlled trial [RCT] 1), on a risk score for developing RA in patients with anti-citrullinated protein antibody (ACPA) positive arthralgia (RCT 2) and on pain, stiffness, and function in patients with MSOA (RCT 3), all in comparison with usual care. We designed three 16-week observer-blind RCTs with a waiting-list control group for patients with RA with low to moderate disease activity (2.6 <= Disease Activity Score [DAS28] <= 5.1, RCT 1, n = 80), for patients at risk for RA, defined by ACPA-positive arthralgia (RCT 2, n = 16) and for patients with metabolic syndrome and OA in the knee and/or hip (RCT 3, n = 80). After personal counseling on diet and exercise, participants join 10 group meetings with 6-12 other patients to receive theoretical and practical training on a WFPD, exercise, and stress management, while medication remains unchanged. The waiting-list control group receives usual care, while entering the program after the RCT. Primary outcomes are: difference in mean change between intervention and control groups within 16 weeks for the DAS28 in RA patients (RCT 1), the RA-risk score for ACPA positive arthralgia patients (RCT 2), and the Western Ontario and McMaster Universities Arthritis Index (WOMAC) score for MSOA patients (RCT 3). Continued adherence to the lifestyle program is measured in a two-year observational extension study.
C1 [Walrabenstein, Wendy; van der Leeden, Marike; Wagenaar, Carlijn; van Boheemen, Laurette; van Schaardenburg, Dirkjan] Reade, Amsterdam Rheumatol & Immunol Ctr, Dr Jan van Breemenstr 2, NL-1056 AB Amsterdam, Netherlands.
   [Walrabenstein, Wendy; Wagenaar, Carlijn; van Boheemen, Laurette; van Schaardenburg, Dirkjan] Univ Amsterdam, Dept Rheumatol & Clin Immunol, Amsterdam UMC, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands.
   [van der Leeden, Marike] Vrije Univ Amsterdam, Dept Rehabil Med, Amsterdam UMC, De Boelelaan 1117, NL-1081 HV Amsterdam, Netherlands.
   [van der Leeden, Marike; van Dongen, Johanna Maria] Amsterdam Publ Hlth Res Inst, De Boelelaan 1085, NL-1081 HV Amsterdam, Netherlands.
   [Weijs, Peter] Amsterdam Univ Appl Sci, Dokter Meurerlaan 8, NL-1067 SM Amsterdam, Netherlands.
   [Weijs, Peter] Vrije Univ Amsterdam, Amsterdam Univ, Dept Nutr & Dietet, Med Ctr, De Boelelaan 1117, NL-1081 HV Amsterdam, Netherlands.
   [van Middendorp, Henriet] Leiden Univ, Inst Psychol, Hlth Med & Neuropsychol Unit, Leiden, Netherlands.
   [van Dongen, Johanna Maria] Vrije Univ Amsterdam, Fac Sci, Dept Hlth Sci, De Boelelaan 1085, NL-1081 HV Amsterdam, Netherlands.
   [Nieuwdorp, Max] Univ Amsterdam, Dept Internal Med, Amsterdam UMC, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands.
   [de Jonge, Catharina Sophia] Univ Amsterdam, Dept Radiol & Nucl Med, Amsterdam UMC, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands.
   [de Jonge, Catharina Sophia] Univ Amsterdam, Dept Gastroenterol Endocrinol Metab, Amsterdam UMC, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands.
C3 Vrije Universiteit Amsterdam; University of Amsterdam; Vrije
   Universiteit Amsterdam; Vrije Universiteit Amsterdam; Leiden University;
   Leiden University - Excl LUMC; Vrije Universiteit Amsterdam; University
   of Amsterdam; University of Amsterdam; University of Amsterdam
RP Walrabenstein, W (corresponding author), Reade, Amsterdam Rheumatol & Immunol Ctr, Dr Jan van Breemenstr 2, NL-1056 AB Amsterdam, Netherlands.; Walrabenstein, W (corresponding author), Univ Amsterdam, Dept Rheumatol & Clin Immunol, Amsterdam UMC, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands.
EM w.walrabenstein@reade.nl
RI de Jonge, Catharina/AEM-1923-2022
OI Weijs, Peter/0000-0001-8281-0426; van Dongen, Johanna
   Maria/0000-0002-1606-8742; van der Leeden, Marike/0000-0001-6465-0983;
   Walrabenstein, Wendy/0000-0002-2428-2845; Wagenaar,
   Carlijn/0000-0002-0937-4450; de Jonge, Catharina/0000-0002-3921-0895
FU Reade (Amsterdam, the Netherlands); Reade Foundation (Amsterdam, the
   Netherlands); private ffoundation, Amsterdam, the Netherlands; W.M. de
   Hoop Stichting (private foundation, Bussum, the Netherlands); ZonMw
   [555003210]; ZonMw VICI grant 2020 [09150182010020]
FX The RCT is funded by Reade (Amsterdam, the Netherlands), Reade
   Foundation (Amsterdam, the Netherlands), Stichting Vermeer 14 (private
   ffoundation, Amsterdam, the Netherlands), and W.M. de Hoop Stichting
   (private foundation, Bussum, the Netherlands). The extension study and
   microbiome studies are funded by ZonMw no. 555003210. MN is supported by
   a ZonMw VICI grant 2020 no. 09150182010020 (see https://www.zonmw.
   nl/en/research-and-results/fundamental-research/programmas/programmedeta
   il/vici/t/awarded-projects/). The funders had no role in the design or
   execution of the study.
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NR 70
TC 28
Z9 28
U1 1
U2 10
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1745-6215
J9 TRIALS
JI Trials
PD OCT 18
PY 2021
VL 22
IS 1
AR 715
DI 10.1186/s13063-021-05682-y
PG 11
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA WI6NF
UT WOS:000708474000009
PM 34663431
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Yao, MY
   Li, LQ
   Ma, JX
   Xue, P
   Li, YK
AF Yao, Ming-yan
   Li, Li-qin
   Ma, Jian-xia
   Xue, Peng
   Li, Yu-kun
TI Use of flash glucose-sensing technology in patients with type 2 diabetes
   treated with liraglutide combined with CSII: a pilot study
SO BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
LA English
DT Article
DE Flash glucose monitoring; Glucagon-like peptide-1 analog; Continuous
   subcutaneous insulin infusion; Glucose fluctuation; Cardiometabolic risk
   markers; Type 2 diabetes
ID INTENSIVE INSULIN THERAPY; OXIDATIVE STRESS; FOLLOW-UP; HYPOGLYCEMIA;
   ADULTS; RISK; COMPLICATIONS; HYPERGLYCEMIA; INFLAMMATION; ADIPONECTIN
AB Glycemic variability (GV) may be linked to the development of diabetic complications by inducing inflammation, oxidative stress, and endothelial dysfunction. Flash glucose monitoring (FGM) provides a novel method of continuously monitoring interstitial glucose levels for up to 14 days. This study randomly assigned poorly controlled type 2 diabetes mellitus patients treated with metformin and multiple daily injections of insulin (n=60) to either continuous subcutaneous insulin infusion (CSII) treatment or CSII in combination with liraglutide (CSII + Lira) treatment for 14 days during hospitalization. GV was assessed using a FGM system; weight and cardiometabolic biomarkers were also evaluated. The coefficient of variation was significantly reduced in the CSII + Lira group (P <0.001), while no significant change was observed in the CSII group. The changes differed significantly between the two groups in mean amplitude of glycemic excursions (P=0.004), standard deviation (P=0.006), and the percentage of time in the target range (4-10 mmol/L, P=0.005 and >10 mmol/L, P=0.028). The changes in mean of daily differences, interquartile range, and percentage of time in hypoglycemia (<3.3 mmol/L) and hyperglycemia (>13.9 mmol/L) identified by FGM showed no difference. Treatment with liraglutide increased serum adiponectin [33.5 (3.5, 47.7) pg/mL, P=0.003] and heme oxygenase-1 levels [0.4 (-0.0, 1.8) ng/mL, P=0.001] and reduced serum leptin levels [-2.8 (3.9) pg/mL, P<0.001]. Adding the glucagon-like peptide-1 analog liraglutide improved GV, weight, and some cardiometabolic risk markers. The FGM system is, therefore, shown to be a novel and useful method for glucose monitoring.
C1 [Yao, Ming-yan; Li, Li-qin; Ma, Jian-xia; Xue, Peng; Li, Yu-kun] Hebei Med Univ, Dept Endocrinol, Hosp 3, Shijiazhuang, Hebei, Peoples R China.
   [Yao, Ming-yan] Baoding 1 Cent Hosp, Dept Endocrinol, Baoding, Hebei, Peoples R China.
C3 Hebei Medical University
RP Li, YK (corresponding author), Hebei Med Univ, Dept Endocrinol, Hosp 3, Shijiazhuang, Hebei, Peoples R China.
EM yhsw667888@163.com
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NR 34
TC 6
Z9 6
U1 0
U2 11
PU ASSOC BRAS DIVULG CIENTIFICA
PI RIBEIRAO PRETO
PA FACULDADE MEDICINA, CASA 10, 14049 RIBEIRAO PRETO, RIBEIRAO PRETO, SP
   14049, BRAZIL
SN 0100-879X
EI 1414-431X
J9 BRAZ J MED BIOL RES
JI Brazilian J. Med. Biol. Res.
PY 2020
VL 53
IS 1
AR e8652
DI 10.1590/1414-431X20198652
PG 10
WC Biology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics; Research & Experimental
   Medicine
GA JX8SM
UT WOS:000503998800001
PM 31859911
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Lago, SG
   Tomasik, J
   van Rees, GF
   Rubey, M
   Gonzalez-Vioque, E
   Ramsey, JM
   Haenisch, F
   Broek, JA
   Vázquez-Bourgon, J
   Papiol, S
   Suarez-Pinilla, P
   Ruland, T
   Auyeug, B
   Mikova, O
   Kabacs, N
   Arolt, V
   Baron-Cohen, S
   Crespo-Facorro, B
   Bahn, S
AF Lago, Santiago G.
   Tomasik, Jakub
   van Rees, Geertje F.
   Rubey, Marina
   Gonzalez-Vioque, Emiliano
   Ramsey, Jordan M.
   Haenisch, Frieder
   Broek, Jantine A.
   Vazquez-Bourgon, Javier
   Papiol, Sergi
   Suarez-Pinilla, Paula
   Ruland, Tillmann
   Auyeug, Bonnie
   Mikova, Olya
   Kabacs, Nikolett
   Arolt, Volker
   Baron-Cohen, Simon
   Crespo-Facorro, Benedicto
   Bahn, Sabine
TI Exploring cellular markers of metabolic syndrome in peripheral blood
   mononuclear cells across the neuropsychiatric spectrum
SO BRAIN BEHAVIOR AND IMMUNITY
LA English
DT Article
DE Neuropsychiatric conditions; Metabolic syndrome; Peripheral blood
   mononuclear cell; Cell surface marker; Insulin sensitivity; Polygenic
   risk score; Homeostasis model assessment; Antipsychotic treatment;
   Response prediction; Weight gain; Flow cytometry
ID MAJOR DEPRESSIVE DISORDER; 1ST-EPISODE SCHIZOPHRENIA;
   ANTIPSYCHOTIC-DRUGS; PREFRONTAL CORTEX; IMMUNE-SYSTEM; PEOPLE; BRAIN;
   RISK; GLUCOSE-TRANSPORTER-1; METAANALYSIS
AB Recent evidence suggests that comorbidities between neuropsychiatric conditions and metabolic syndrome may precede and even exacerbate long-term side-effects of psychiatric medication, such as a higher risk of type 2 diabetes and cardiovascular disease, which result in increased mortality. In the present study we compare the expression of key metabolic proteins, including the insulin receptor (CD220), glucose transporter 1 (GLUT1) and fatty acid translocase (CD36), on peripheral blood mononuclear cell subtypes from patients across the neuropsychiatric spectrum, including schizophrenia, bipolar disorder, major depression and autism spectrum conditions (n = 25/condition), relative to typical controls (n = 100). This revealed alterations in the expression of these proteins that were specific to schizophrenia. Further characterization of metabolic alterations in an extended cohort of first-onset antipsychotic drug-naive schizophrenia patients (n = 58) and controls (n = 63) revealed that the relationship between insulin receptor expression in monocytes and physiological insulin sensitivity was disrupted in schizophrenia and that altered expression of the insulin receptor was associated with whole genome polygenic risk scores for schizophrenia. Finally, longitudinal follow-up of the schizophrenia patients over the course of antipsychotic drug treatment revealed that peripheral metabolic markers predicted changes in psychopathology and the principal side effect of weight gain at clinically relevant time points. These findings suggest that peripheral blood cells can provide an accessible surrogate model for metabolic alterations in schizophrenia and have the potential to stratify subgroups of patients with different clinical outcomes or a greater risk of developing metabolic complications following antipsychotic therapy.
C1 [Lago, Santiago G.; Tomasik, Jakub; van Rees, Geertje F.; Rubey, Marina; Gonzalez-Vioque, Emiliano; Ramsey, Jordan M.; Haenisch, Frieder; Broek, Jantine A.; Bahn, Sabine] Univ Cambridge, Dept Chem Engn & Biotechnol, Philippa Fawcett Dr, Cambridge CB3 0AS, England.
   [Vazquez-Bourgon, Javier; Suarez-Pinilla, Paula; Auyeug, Bonnie; Crespo-Facorro, Benedicto] Univ Cantabria, Marques Valdecilla Univ Hosp, IDIVAL, Sch Med,Dept Psychiat, Santander, Spain.
   [Vazquez-Bourgon, Javier; Suarez-Pinilla, Paula] Ctr Invest Biomed Red Salud Mental CIBERSAM, Santander, Spain.
   [Papiol, Sergi] Ctr Invest Biomed Red Salud Mental CIBERSAM, Barcelona, Spain.
   [Papiol, Sergi; Crespo-Facorro, Benedicto] Ludwig Maximilians Univ Munchen, Univ Hosp, Inst Psychiat Phen & Genom, Munich, Germany.
   [Papiol, Sergi] Ludwig Maximilians Univ Munchen, Univ Hosp, Dept Psychiat & Psychotherapy, Munich, Germany.
   [Ruland, Tillmann; Arolt, Volker] Univ Hosp Munster, Munster, Germany.
   [Baron-Cohen, Simon] Univ Cambridge, Dept Psychiat, Autism Res Ctr, Cambridge, England.
   [Mikova, Olya] Fdn Biol Psychiat, Sofia, Bulgaria.
   [Kabacs, Nikolett] Cambridgeshire & Peterborough NHS Fdn TrustCambri, Cambridge, England.
   [Crespo-Facorro, Benedicto] Univ Hosp Virgen Rocio, Sch Med, Dept Psychiat, IBiS, Seville, Spain.
   [Crespo-Facorro, Benedicto] Ctr Invest Biomed Red Salud Mental CIBERSAM, Seville, Spain.
   [Gonzalez-Vioque, Emiliano] Univ Santiago de Compostela, Unit Diag & Treatment Congenital Metab Dis, Hlth Res Inst Santiago Compostela IDIS, Hosp Clin, Santiago De Compostela, Spain.
   [Auyeug, Bonnie] Univ Edinburgh, Psychol Dept, Edinburgh, Midlothian, Scotland.
C3 University of Cambridge; Hospital Universitario Marques de Valdecilla
   (HUMV); Universidad de Cantabria; CIBER - Centro de Investigacion
   Biomedica en Red; CIBERSAM; CIBER - Centro de Investigacion Biomedica en
   Red; CIBERSAM; University of Munich; University of Munich; University of
   Munster; University of Cambridge; Consejo Superior de Investigaciones
   Cientificas (CSIC); University of Sevilla; CSIC-JA-USE - Instituto de
   Biomedicina de Sevilla (IBIS); Virgen del Rocio University Hospital;
   CIBER - Centro de Investigacion Biomedica en Red; CIBERSAM; Complexo
   Hospitalario Universitario de Santiago de Compostela; Universidade de
   Santiago de Compostela; University of Edinburgh
RP Bahn, S (corresponding author), Univ Cambridge, Dept Chem Engn & Biotechnol, Philippa Fawcett Dr, Cambridge CB3 0AS, England.
EM sb209@cam.ac.uk
RI Tomasik, Jakub/JTS-5325-2023; Vázquez-Bourgon, Javier/H-8496-2019;
   Crespo-Facorro, BENEDICTO/AAY-2238-2021; Baron-Cohen,
   Simon/JPA-2618-2023; Haenisch, Frieder/HTP-2221-2023; Haenisch,
   Frieder/N-1765-2015
OI Vazquez-Bourgon, Javier/0000-0002-5478-3376; van Rees,
   Geertje/0000-0002-9431-0653; Tomasik, Jakub/0000-0002-2127-4487; Dias,
   Debora/0009-0004-6164-5360; Baron-Cohen, Simon/0000-0001-9217-2544;
   Papiol, Sergi/0000-0001-9366-8728; Haenisch,
   Frieder/0000-0001-7961-4467; Crespo-Facorro,
   Benedicto/0000-0003-0033-7132
FU Stanley Medical Research Institute (SMRI); Engineering and Physical
   Sciences Research Council UK (EPSRC); Dutch Government-funded Virgo
   consortium [FES0908]; Netherlands Genomics Initiative [050-060-452];
   European Union FP7 funding scheme: Marie Curie Actions Industry Academia
   Partnerships and Pathways [286334]; MINECO [SAF2016-76046-R,
   SAF2013-46292-R]; ISCIII [PI16/00156]; FEDER [PI16/00156]
FX We are highly indebted to the participants and their families for their
   cooperation in this study. We would like to thank blood donors and the
   clinical centres, for provision of biological samples, in addition to
   support staff at the affiliated institutions. We thank IDIVAL biobank
   (Ines Santiuste and Jana Arozamena) for clinical samples and data as
   well as the PAFIP members for the data collection. This work was
   supported by grants from the Stanley Medical Research Institute (SMRI);
   the Engineering and Physical Sciences Research Council UK (EPSRC); the
   Dutch Government-funded Virgo consortium (ref. FES0908); the Netherlands
   Genomics Initiative (ref. 050-060-452); the European Union FP7 funding
   scheme: Marie Curie Actions Industry Academia Partnerships and Pathways
   (ref. 286334, PSYCH-AID project); SAF2016-76046-R and SAF2013-46292-R
   (MINECO) and PI16/00156 (ISCIII and FEDER).
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NR 112
TC 15
Z9 15
U1 2
U2 13
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0889-1591
EI 1090-2139
J9 BRAIN BEHAV IMMUN
JI Brain Behav. Immun.
PD JAN
PY 2021
VL 91
BP 673
EP 682
DI 10.1016/j.bbi.2020.07.043
PG 10
WC Immunology; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Immunology; Neurosciences & Neurology; Psychiatry
GA PL4LY
UT WOS:000603096600007
PM 32898636
OA Green Published, hybrid, Green Submitted
DA 2025-06-11
ER

PT J
AU Santos-Calderón, LA
   Vargas-Morales, JM
   Capello, OSA
   Terán-García, M
   Cossío-Torres, PE
   Vidal-Batres, M
   Fernández-Ballart, JD
   Aradillas-García, C
AF Adolfo Santos-Calderon, Luis
   Manuel Vargas-Morales, Juan
   Sanchez-Armass Capello, Omar
   Teran-Garcia, Margarita
   Elizabeth Cossio-Torres, Patricia
   Vidal-Batres, Marisol
   Fernandez-Ballart, Joan D.
   Aradillas-Garcia, Celia
CA UP AMIGOS Team
TI Association between birthweight, cardiovascular risk factors, and
   depression in young Mexican adults
SO NUTRICION HOSPITALARIA
LA English
DT Article
DE Birthweight; Cardiovascular risk; Depression; Mexican population
ID SYSTOLIC BLOOD-PRESSURE; METABOLIC SYNDROME; GESTATIONAL-AGE; DISORDERS;
   ORIGINS; ADOLESCENTS; PREVENTION; CHILDHOOD; CHILDREN; DISEASE
AB Background: the aim of this study was to investigate the association between birthweight, cardiovascular disease (CVD) risk factors, and depression in young Mexican adults.
   Methods: birthweight reports, family history of CVD and diabetes-related diseases, anthropometrics, serum lipid profile (total cholesterol [TC], triglycerides [TG], high-density lipoprotein-cholesterol [HDL-C], low-density lipoprotein-cholesterol [LDL-C], and very-low density lipoprotein-cholesterol [VLDL-C]), and depressive symptoms were measured in 778 subjects of the UP-AMIGOS cohort study. To investigate the association between birthweight categories and CVD risk factors and depression, a one-way analysis of variance with post-hoc test was performed of quantitative variables, and chi(2) test for qualitative variables.
   Results: mean age was 17.8 years and 469 (60.3 %) of patients were female (n = 469, 60.3 %). The percentage of patients with low birthweight (LBW) was 8.1 % (n = 63), and 3.3 % (n = 26) reported high birthweight (HBW). Young adults with HBW were associated with elevated diastolic blood pressure (DBP), and high weight and body mass index (BMI) when compared to LBW subjects, the difference being statically significant (p < 0.05). Birthweight had no significant association with depression (p > 0.67).
   Conclusion: the findings from this population-based study revealed a positive relation between birthweight categories and some CVD risk factors. Depression was not related to birthweight.
C1 [Adolfo Santos-Calderon, Luis] Univ Autonoma San Luis Potosi, Fac Med, San Luis Potosi, San Luis Potosi, Mexico.
   [Manuel Vargas-Morales, Juan] Univ Autonoma San Luis Potosi, Fac Ciencias Quim, San Luis Potosi, San Luis Potosi, Mexico.
   [Sanchez-Armass Capello, Omar] Univ Autonoma San Luis Potosi, Fac Psicol, San Luis Potosi, San Luis Potosi, Mexico.
   [Teran-Garcia, Margarita] Univ Illinois, Champaign, IL 61820 USA.
   [Elizabeth Cossio-Torres, Patricia] Univ Autonoma San Luis Potosi, Dept Salud Publ, Fac Med, San Luis Potosi, San Luis Potosi, Mexico.
   [Vidal-Batres, Marisol] Univ Autonoma San Luis Potosi, Coordinac Innovac & Aplicac Ciencia & Tecnol CIAC, San Luis Potosi, San Luis Potosi, Mexico.
   [Fernandez-Ballart, Joan D.] Univ Rovira & Virgili, Med Prevent & Salud Publ, Fac Med & Ciencias Salud, Tarragona, Spain.
   [Aradillas-Garcia, Celia] Univ Autonoma San Luis Potosi, Ctr Invest Aplicada Ambiente & Salud CIAAS, Fac Med, CIACYT, Av Sierra Leona 550-2a, San Luis Potosi 78210, San Luis Potosi, Mexico.
C3 Universidad Autonoma de San Luis Potosi; Universidad Autonoma de San
   Luis Potosi; Universidad Autonoma de San Luis Potosi; University of
   Illinois System; University of Illinois Urbana-Champaign; Universidad
   Autonoma de San Luis Potosi; Universidad Autonoma de San Luis Potosi;
   Universitat Rovira i Virgili; Universidad Autonoma de San Luis Potosi
RP Aradillas-García, C (corresponding author), Univ Autonoma San Luis Potosi, Ctr Invest Aplicada Ambiente & Salud CIAAS, Fac Med, CIACYT, Av Sierra Leona 550-2a, San Luis Potosi 78210, San Luis Potosi, Mexico.
EM celia@uaslp.com
RI Garcia, Celia/B-5830-2014; Teran-Garcia, Margarita/B-5344-2009;
   Cossio-Torres, Patricia/AAA-3632-2021; Santos Calderon,
   Luis/HJI-3458-2023; Fernández Barredo, Juan/JLK-8499-2023
OI Vidal-Batres, Marisol/0000-0002-8245-6065; Cossio-Torres, Patricia
   Elizabeth/0000-0002-7626-8949; Sanchez-Armass, Omar/0000-0001-8064-2502;
   Santos Calderon, Luis Adolfo/0000-0002-6871-1103; Fernandez-Ballart,
   Joan D./0000-0002-1320-6484
FU UASLP Hormones Laboratory at the School of Medicine [C09-PIFI-030606];
   UASLP Hormones Laboratory at the Clinical Biochemistry Laboratory
   [C09-PIFI-030606]; UASLP Hormones Laboratory at the Chemical Sciences
   School [C09-PIFI-030606]; University of Illinois at Urbana-Champaign
   Research Board [09070]; University of Illinois at Center on Health,
   Aging, and Disability; USDA National Institute of Food and Agriculture,
   Hatch Projects [600108-793000-793323, 600109-698000-698354]; UASLP
   Hormones Laboratory at the University Health Center [C09-PIFI-030606]
FX this research was funded by grants from the UASLP Hormones Laboratory at
   the School of Medicine, Clinical Biochemistry Laboratory, Chemical
   Sciences School, and the University Health Center under agreement
   support C09-PIFI-030606 (to C. Aradillas-Garcia); the University of
   Illinois at Urbana-Champaign Research Board (#09070) and Center on
   Health, Aging, and Disability (to F. Andrade); and the USDA National
   Institute of Food and Agriculture, Hatch Projects #600108-793000793323
   (to M. Raffaelli) and #600109-698000-698354 (to M. Teran-Garcia).
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NR 40
TC 1
Z9 1
U1 1
U2 5
PU ARAN EDICIONES, S L
PI MADRID
PA C/ CASTELLO, 128, 1O, MADRID, 28006, SPAIN
SN 0212-1611
EI 1699-5198
J9 NUTR HOSP
JI Nutr. Hosp.
PD JUL-AUG
PY 2021
VL 38
IS 4
BP 833
EP 838
AR 03547
DI 10.20960/nh.03547
PG 6
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA TP9OS
UT WOS:000677922200023
PM 34120446
OA gold
DA 2025-06-11
ER

PT J
AU Li, FL
   Tang, H
   Xiao, FR
   Gong, JL
   Peng, Y
   Meng, XL
AF Li, Fenglin
   Tang, Hong
   Xiao, Furen
   Gong, Jingli
   Peng, Yong
   Meng, Xiangle
TI Protective Effect of Salidroside from Rhodiolae Radix on
   Diabetes-Induced Oxidative Stress in Mice
SO MOLECULES
LA English
DT Article
DE oxidative stress; diabetes mellitus; salidroside; hypoglycemic; mice
ID METABOLIC SYNDROME; IN-VITRO; EXTRACT; SACHALINENSIS; THERAPY; ACID
AB It has been confirmed that diabetes mellitus (DM) carries increased oxidative stress. This study evaluated the effects of salidroside from Rhodiolae Radix on diabetes-induced oxidative stress in mice. After induction of diabetes, diabetic mice were administered daily doses of 50, 100 and 200 mg/kg salidroside for 28 days. Body weights, fasting blood glucose (FBG), serum insulin, TC (total cholesterol), TG (triglyceride), malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT) were measured. Results showed that salidroside possessed hypoglycemic activity and protective effects against diabetes-induced oxidative stress, which could significantly reduce FBG, TC, TG and MDA levels, and at same time increase serum insulin levels, SOD, GPx and CAT activities. Therefore, salidroside should be considered as a candidate for future studies on diabetes.
C1 [Li, Fenglin; Xiao, Furen] Yanshan Univ, Coll Mat Sci & Engn, Key Lab Metastable Mat Sci & Technol, Qinhuangdao 066004, Peoples R China.
   [Li, Fenglin; Gong, Jingli] Jilin Agr Sci & Technol Coll, Dept Bioengn, Jilin 132101, Peoples R China.
   [Tang, Hong] Shanghai Univ Tradit Chinese Med, Longhua Hosp, Dept Endocrinol, Shanghai 200032, Peoples R China.
   [Peng, Yong] Yanshan Univ, Coll Environm & Chem Engn, Qinhuangdao 066004, Peoples R China.
   [Meng, Xiangle] Henan Coll Tradit Chinese Med, Dept Pharm, Affiliated Hosp 1, Zhengzhou 450000, Peoples R China.
C3 Yanshan University; Jilin Agricultural Science & Technology University;
   Shanghai University of Traditional Chinese Medicine; Yanshan University;
   Henan University of Traditional Chinese Medicine
RP Xiao, FR (corresponding author), Yanshan Univ, Coll Mat Sci & Engn, Key Lab Metastable Mat Sci & Technol, Qinhuangdao 066004, Peoples R China.
EM swgclfl@163.com; lhhong_tang@qq.com; swgclifenglin@sina.com;
   591142473@qq.com; py81ysu@126.com; mxiangle@yahoo.cn
OI Xiao, Furen/0000-0002-3076-2730
FU Natural Sciences Foundation of Jilin Province [20090905]; Natural
   Science Foundation for Young Scientists of Jilin Agricultural Science
   and Technology College [2010124]
FX This work was supported by the Natural Sciences Foundation of Jilin
   Province (Grant No. 20090905) and Natural Science Foundation for Young
   Scientists of Jilin Agricultural Science and Technology College (Grant
   No. 2010124).
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NR 55
TC 75
Z9 88
U1 2
U2 37
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1420-3049
J9 MOLECULES
JI Molecules
PD DEC
PY 2011
VL 16
IS 12
BP 9912
EP 9924
DI 10.3390/molecules16129912
PG 13
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 866UQ
UT WOS:000298411200011
PM 22134398
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Minami, A
   Matsushita, H
   Leno, D
   Matsuda, Y
   Horii, Y
   Ishii, A
   Takahashi, T
   Kanazawa, H
   Wakatsuki, A
   Suzuki, T
AF Minami, A.
   Matsushita, H.
   Leno, D.
   Matsuda, Y.
   Horii, Y.
   Ishii, A.
   Takahashi, T.
   Kanazawa, H.
   Wakatsuki, A.
   Suzuki, T.
TI Improvement of neurological disorders in postmenopausal model rats by
   administration of royal jelly
SO CLIMACTERIC
LA English
DT Article
DE Royal jelly; estrogen; memory impairment; depression; ovariectomized
   rat; postmenopausal; syndrome; fatty acids; sterols
ID ESTROGEN-RECEPTOR-ALPHA; HORMONE REPLACEMENT THERAPY; RECOGNITION
   MEMORY; ESTRADIOL; WOMEN; BEHAVIOR; BETA; DEPRESSION; AGONIST; CELLS
AB Objective: Royal jelly (RJ) from honeybees (Apis mellifera) has estrogenic activity. Estrogen deficiency after menopause leads to a high risk of memory impairment and depression as well as metabolic syndrome and osteoporosis. We here investigated the effect of RJ on memory impairment and depression-like behaviors in ovariectomized (OVX) rats.
   Methods: OVX rats were administered with RJ for 82 days. Hippocampus-dependent spatial memory and depression-like behaviors were assessed by the Morris water maze test and the forced swimming test, respectively. The weights of body, brain and uterus and the contents of protein and myelin galactolipids including galactosylceramide and sulfatide were measured.
   Results: Memory impairment and depression-like behaviors in OVX rats were recovered to the levels of sham-operated rats by RJ administration. Increased body weight and decreased uterine weight in OVX rats were recovered to the levels of sham-operated rats by 17 beta-estradiol (E2) administration but not by RJ administration. In contrast, brain weight was slightly increased by RJ administration but not by E2 administration. The contents of protein and myelin galactolipids were higher in the brains of RJ-administered OVX rats than in the brains of E2-administered OVX rats.
   Conclusion: The results suggest that RJ has a beneficial effect on neurological symptoms of a menopausal disorder.
C1 [Minami, A.; Leno, D.; Matsuda, Y.; Horii, Y.; Ishii, A.; Takahashi, T.; Suzuki, T.] Univ Shizuoka, Sch Pharmaceut Sci, Dept Biochem, Shizuoka, Japan.
   [Matsushita, H.; Wakatsuki, A.] Aichi Med Univ, Sch Med, Dept Obstet & Gynecol, Nagakute, Aichi, Japan.
   [Kanazawa, H.] Univ Shizuoka, Sch Nursing, Dept Funct Anat, Shizuoka, Japan.
C3 University of Shizuoka; Aichi Medical University; University of Shizuoka
RP Suzuki, T (corresponding author), Univ Shizuoka, Sch Pharmaceut Sci, Dept Biochem, Suruga Ku, 52-1 Yada, Shizuoka 4228526, Japan.
EM suzukit@u-shizuoka-ken.ac.jp
RI Matsushita, Hiroshi/AFQ-0956-2022
FU Japan Society for Menopause and Women's Health under JMWH Bayer Grant;
   Yamada Bee Company under Yamada Research Grant; Kanae Foundation for the
   Promotion of Medical Science under Asia Oceania Collaborative Research
   Grants; Japan Menopause Society under JMS Bayer Schering Pharma Grant;
   Grants-in-Aid for Scientific Research [15H05644, 16K15151, 16K08277]
   Funding Source: KAKEN
FX This research was supported by the Japan Society for Menopause and
   Women's Health under the JMWH Bayer Grant; Yamada Bee Company under the
   Yamada Research Grant; and The Kanae Foundation for the Promotion of
   Medical Science under the Asia Oceania Collaborative Research Grants to
   A.M and by the Japan Menopause Society under the JMS Bayer Schering
   Pharma Grant to H.M.
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NR 50
TC 27
Z9 30
U1 0
U2 17
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1369-7137
EI 1473-0804
J9 CLIMACTERIC
JI Climacteric
PD DEC
PY 2016
VL 19
IS 6
BP 568
EP 573
DI 10.1080/13697137.2016.1238452
PG 6
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA ED8DJ
UT WOS:000389101900011
PM 27736245
DA 2025-06-11
ER

PT J
AU Srikanthan, K
   Shapiro, JI
   Sodhi, K
AF Srikanthan, Krithika
   Shapiro, Joseph I.
   Sodhi, Komal
TI The Role of Na/K-ATPase Signaling in Oxidative Stress Related to Obesity
   and Cardiovascular Disease
SO MOLECULES
LA English
DT Review
DE Na/K-ATPase; oxidative stress; pNaKtide; obesity; cardiovascular disease
ID NA+/K+-ATPASE; ADIPOSE-TISSUE; DIFFERENT SENSITIVITIES; METABOLIC
   SYNDROME; OXIDANT STRESS; SRC KINASE; K-ATPASE; C-SRC; ACTIVATION;
   MECHANISM
AB Na/K-ATPase has been extensively studied for its ion pumping function, but, in the past several decades, has been identified as a scaffolding and signaling protein. Initially it was found that cardiotonic steroids (CTS) mediate signal transduction through the Na/K-ATPase and result in the generation of reactive oxygen species (ROS), which are also capable of initiating the signal cascade. However, in recent years, this Na/K-ATPase/ROS amplification loop has demonstrated significance in oxidative stress related disease states, including obesity, atherosclerosis, heart failure, uremic cardiomyopathy, and hypertension. The discovery of this novel oxidative stress signaling pathway, holds significant therapeutic potential for the aforementioned conditions and others that are rooted in ROS.
C1 [Srikanthan, Krithika; Shapiro, Joseph I.] Marshall Univ, Joan C Edwards Sch Med, Dept Med, Huntington, WV 25701 USA.
   [Sodhi, Komal] Marshall Univ, Joan C Edwards Sch Med, Dept Surg, Huntington, WV 25701 USA.
C3 Marshall University; Marshall University
RP Sodhi, K (corresponding author), Marshall Univ, Joan C Edwards Sch Med, Dept Surg, Huntington, WV 25701 USA.
EM srikanthan.krithika@gmail.com; shapiroj@marshall.edu; sodhi@marshall.edu
RI Stefanadis, Christodoulos/ABH-2232-2020
OI Stefanadis, Christodoulos/0000-0001-5974-6454
FU NIH [HL109015, HL071556, HL105649]; Brickstreet Foundation; Huntington
   Foundation Inc.
FX This work was supported by NIH grants HL109015, HL071556, HL105649, the
   Brickstreet Foundation, and the Huntington Foundation Inc.
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NR 74
TC 65
Z9 70
U1 1
U2 17
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1420-3049
J9 MOLECULES
JI Molecules
PD SEP
PY 2016
VL 21
IS 9
AR 1172
DI 10.3390/molecules21091172
PG 13
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA DY9UE
UT WOS:000385479800069
PM 27598118
OA Green Published, gold, Green Accepted
DA 2025-06-11
ER

PT J
AU Zhang, QY
   Dong, GZ
   Zhu, XY
   Cao, Y
   Zhang, XY
AF Zhang, Qiaoyang
   Dong, Guanzhong
   Zhu, Xuanyan
   Cao, Yin
   Zhang, Xiangyang
TI Elevated thyroid stimulating hormone and metabolic syndrome risk in
   patients with first-episode and drug-naïve major depressive disorder: a
   large-scale cross-sectional study
SO BMC PSYCHIATRY
LA English
DT Article
DE Metabolic syndrome; Depression; Thyroid; TSH
ID FREE THYROXINE CONCENTRATION
AB Background Metabolic syndrome (MetS) is common in major depressive disorder (MDD), but its relationship with thyroid hormones remains unclear. We aimed to examine the association of thyroid hormones and MetS in first-episode drug-na & iuml;ve (FEDN) MDD patients. Methods We recruited 1718 unmedicated MDD patients in this cross-sectional study. MetS was defined based on the 2004 Chinese Diabetes Society Criteria. Serum thyroid hormones including free thyroxine (FT4), free triiodothyronine (FT3), thyroid-stimulating hormone (TSH), thyroid peroxidase antibodies (TPOAb), and anti-thyroglobulin (TGAb) were examined. We used the logistic regression model to determine risk factors for MetS and examined the performance of the regression model by using the Area Under the Curve (AUC). In addition, we performed the trend test to test whether the results were robust. Results The prevalence of MetS in unmedicated MDD patients was 34.4%. MDD patients with MetS had higher levels of serum TSH, TGAb, and TPOAb (all P < 0.001). Concurrently, serum TSH levels were independent risk factors for MetS in MDD patients (OR:1.49, 95%CI: 1.40-1.58), which could also distinguish MDD patients with and without MetS (AUC was 0.77). Additionally, in the trend test, the results also indicated a similar trend when TSH was used as a categorical variable (P for trend < 0.001). Conclusions This study suggests that TSH levels were independent risk factors for MetS in FEDN MDD patients (OR:1.49). The examination of thyroid function may contribute to the early detection of MetS.
C1 [Zhang, Qiaoyang; Dong, Guanzhong; Zhu, Xuanyan; Cao, Yin] Nanjing Med Univ, Dept Psychol, Affiliated Changzhou Second Peoples Hosp, Changzhou, Jiangsu, Peoples R China.
   [Cao, Yin] Nanjing Med Univ, Changzhou Med Ctr, Nanjing, Jiangsu, Peoples R China.
   [Zhang, Xiangyang] Chinese Acad Sci, Inst Psychol, 16 Lincui Rd, Beijing 100101, Peoples R China.
   [Zhang, Xiangyang] Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China.
C3 Nanjing Medical University; Nanjing Medical University; Chinese Academy
   of Sciences; Institute of Psychology, CAS; Chinese Academy of Sciences;
   University of Chinese Academy of Sciences, CAS
RP Cao, Y (corresponding author), Nanjing Med Univ, Dept Psychol, Affiliated Changzhou Second Peoples Hosp, Changzhou, Jiangsu, Peoples R China.; Cao, Y (corresponding author), Nanjing Med Univ, Changzhou Med Ctr, Nanjing, Jiangsu, Peoples R China.; Zhang, XY (corresponding author), Chinese Acad Sci, Inst Psychol, 16 Lincui Rd, Beijing 100101, Peoples R China.; Zhang, XY (corresponding author), Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China.
EM czeyxlk@163.com; zhangxy@psych.ac.cn
RI Zhang, Xiangyang/ABC-7380-2022
OI , cao yin/0000-0001-6549-525X; Zhang, Xiangyang/0000-0003-3326-382X
FU Science and Technology Development Program of Nanjing Medical University
FX Not applicable.
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NR 34
TC 1
Z9 1
U1 1
U2 2
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-244X
J9 BMC PSYCHIATRY
JI BMC Psychiatry
PD MAY 21
PY 2024
VL 24
IS 1
AR 380
DI 10.1186/s12888-024-05847-4
PG 7
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychiatry
GA RP6J5
UT WOS:001228901200006
PM 38773550
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Tsai, SW
   Chan, YC
   Liang, F
   Hsu, CY
   Lee, IT
AF Tsai, Sen-Wei
   Chan, Yin-Ching
   Liang, Francois
   Hsu, Chiann-Yi
   Lee, I-Te
TI Brain-derived neurotrophic factor correlated with muscle strength in
   subjects undergoing stationary bicycle exercise training
SO JOURNAL OF DIABETES AND ITS COMPLICATIONS
LA English
DT Article
DE Brain-derived neurotrophic factor; Body weight; Bicycle exercise;
   Metabolic syndrome; Muscle strength
ID METABOLIC SYNDROME; SKELETAL-MUSCLE; BODY-WEIGHT; FOOD-INTAKE; BDNF;
   DEPRESSION; PROTEIN; PLASMA; SERUM; RISK
AB Aims: Several central nervous disorders are associated with metabolic syndrome (MetS) and type 2 diabetes. Reduction in brain-derived neurotrophic factor (BDNF) is involved in the mechanism of central nervous dysfunction. BDNF is up-regulated after exercise, but it is not known whether increased BDNF is related to increases in muscle strength.
   Methods: In the present study, subjects with MetS or type 2 diabetes were enrolled in an exercise program. All participants underwent an indoor bicycle exercise program for twelve weeks. Serum BDNF was determined after overnight fasting. Muscle strength was assessed by extension of the dominant lower extremity.
   Results: A total of 33 subjects were enrolled in this study. The body mass index did not change significantly (from 30.4 +/- 6.0 to 30.2 +/- 5.8 kg/m(2), P = 0.436), but serum BDNF increased significantly (from 17.1 +/- 9.1 to 24.2 +/- 10.7 ng/mL, P < 0.001) after the study. The exercise-associated BDNF was significantly correlated with the increased strength in lower-extremity extension test (r = 0.54, P = 0.001). Using multivariate regression analysis, muscle-strength increment, but not body-weight change, was an independent factor for serum BDNF (95% CI = 0.009-0.044, P = 0.005).
   Conclusions: After a twelve-week program of stationary bicycle exercise, serum BDNF concentration increased, and this change was positively correlated with muscle strength of lower-extremity extension, but not body weight. (Trial registration: NCT02268292, ClinicalTrials.gov) (C) 2015 Elsevier Inc. All rights reserved.
C1 [Tsai, Sen-Wei] Buddhist Tzu Chi Med Fdn, Taichung Tzu Chi Hosp, Dept Phys Med & Rehabil, Taichung 404, Taiwan.
   [Tsai, Sen-Wei] Tzu Chi Univ, Sch Med, Hualien 970, Taiwan.
   [Tsai, Sen-Wei] Natl Taichung Univ Sci & Technol, Ctr Gen Educ, Taichung 404, Taiwan.
   [Tsai, Sen-Wei] Taichung Vet Gen Hosp, Dept Phys Med & Rehabil, Taichung 407, Taiwan.
   [Chan, Yin-Ching] Providence Univ, Dept Food & Nutr, Taichung 433, Taiwan.
   [Liang, Francois] Cycling & Hlth Tech Ind R&D Ctr, Taichung 407, Taiwan.
   [Hsu, Chiann-Yi] Taichung Vet Gen Hosp, Dept Med Res, Taichung 407, Taiwan.
   [Lee, I-Te] Taichung Vet Gen Hosp, Dept Internal Med, Div Endocrinol & Metab, Taichung 407, Taiwan.
   [Lee, I-Te] Natl Yang Ming Univ, Sch Med, Taipei 112, Taiwan.
   [Lee, I-Te] Chung Shan Med Univ, Sch Med, Taichung 402, Taiwan.
C3 Buddhist Tzu Chi General Hospital; Taichung Tzu Chi Hospital; Tzu Chi
   University; National Taichung University of Science & Technology;
   Taichung Veterans General Hospital; Providence University - Taiwan;
   Taichung Veterans General Hospital; Taichung Veterans General Hospital;
   National Yang Ming Chiao Tung University; Chung Shan Medical University
RP Lee, IT (corresponding author), 1650 Taiwan Blvd Sect 4, Taichung 407, Taiwan.
EM itlee@vghtc.gov.tw
OI Lee, I-Te/0000-0003-2665-3635; Chan, Yin Ching/0000-0001-9602-0775
FU Cycling & Health Tech Industry RD Center; Taichung Veterans General
   Hospital, Taichung, Taiwan [103DHA0500405]
FX The work was supported by grants from the Cycling & Health Tech Industry
   R&D Center, and the Taichung Veterans General Hospital (103DHA0500405),
   Taichung, Taiwan. The statistical analysis was performed by
   Biostatistics Task Force of Taichung Veterans General Hospital,
   Taichung, Taiwan, R.O.C.
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NR 43
TC 24
Z9 27
U1 0
U2 10
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1056-8727
EI 1873-460X
J9 J DIABETES COMPLICAT
JI J. Diabetes Complications
PD APR
PY 2015
VL 29
IS 3
BP 367
EP 371
DI 10.1016/j.jdiacomp.2015.01.014
PG 5
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA CE8TN
UT WOS:000352117100009
PM 25682570
DA 2025-06-11
ER

PT J
AU Alemohammad, ZB
   Sadeghniiat-Haghighi, K
   Mehraban, M
   Fazlipanah, P
   Rahimi-Golkhandan, A
AF Alemohammad, Zahra Banafsheh
   Sadeghniiat-Haghighi, Khosro
   Mehraban, Mohammad
   Fazlipanah, Parisa
   Rahimi-Golkhandan, Ania
TI The effects of CPAP therapy on metabolic profile and subjective sleep
   parameters in patients with OSA: a prospective trial study
SO SLEEP SCIENCE
LA English
DT Article
DE Sleep; Apnea; Metabolic Syndrome; Continuous Positive Airway Pressure
ID POSITIVE AIRWAY PRESSURE; DAYTIME SLEEPINESS; APNEA; EPIDEMIOLOGY;
   DEFINITION; INSOMNIA
AB Objective: Several studies confirmed a positive association between obstructive sleep apnea (OSA) and metabolic syndrome. Continuous positive airway pressure (CPAP) is the main treatment for patients with moderate and severe OSA. CPAP therapy in adults with OSA results in reduction in sleepiness, blood pressure and improvement of metabolic profile. In this study, we aimed to evaluate the effects of CPAP therapy on various components of metabolic syndrome and subjective sleep parameters in patients with OSA. Material and Methods: In this prospective trial study, 28 patients with moderate and severe OSA enrolled. Patients were asked to fill out the validated Persian version of questionnaires including Epworth sleepiness scale, insomnia severity index, STOP-BANG and Beck depression inventory - II, before and after treatment with CPAP. Weight and blood pressure were recorded before and after treatment. Only 14 patients agreed to blood sampling before and after CPAP therapy (at least 3 months of treatment). Fasting blood samples were analyzed for measuring the levels of FBS (fasting blood sugar), TG (triglyceride), total cholesterol, HDL, LDL, AST, and ALT. Results: Diastolic blood pressure, ISI and STOP-BANG score significantly decreased after treatment (p-value: 0.008, 0.022 and 0.004, respectively). FBS and TG levels decreased after treatment, but only TG levels had significant difference (p-value: 0.46 and 0.016, respectively). Discussion: CPAP therapy had positive effects on diastolic blood pressure, TG levels and ISI score. More studies with larger sample size and longer follow-up periods are warranted to investigate the effects of CPAP therapy on blood pressure, and metabolic parameters.
C1 [Alemohammad, Zahra Banafsheh; Sadeghniiat-Haghighi, Khosro; Mehraban, Mohammad; Fazlipanah, Parisa; Rahimi-Golkhandan, Ania] Univ Tehran Med Sci, Baharloo Hosp, Occupat Sleep Res Ctr, Tehran, Iran.
C3 Tehran University of Medical Sciences
RP Rahimi-Golkhandan, A (corresponding author), Univ Tehran Med Sci, Baharloo Hosp, Occupat Sleep Res Ctr, Tehran, Iran.
EM aniarahimi.g@gmail.com
RI Adel-Mehraban, Mohammad Sadegh/ABD-8813-2021; Alemohammad, Zahra
   Banafsheh/ABG-3882-2021
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NR 32
TC 2
Z9 3
U1 1
U2 2
PU BRAZILIAN ASSOC SLEEP
PI SAO PAULO
PA RUA DR DIOGO FARIA, 508, VILA CLEMENTINO, SAO PAULO, SP 04037-001,
   BRAZIL
SN 1984-0659
EI 1984-0063
J9 SLEEP SCI
JI Sleep Sci.
PY 2022
VL 15
IS 2
BP 195
EP 199
DI 10.5935/1984-0063.20220041
PG 5
WC Clinical Neurology
WE Emerging Sources Citation Index (ESCI)
SC Neurosciences & Neurology
GA 1Y9FG
UT WOS:000808441900009
PM 35755912
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Choi, WJ
   Shin, D
AF Choi, Woo Jeong
   Shin, Dayeon
TI Interactions between red and processed meat consumption and APOA5
   gene variants associated with the incidence of metabolic syndrome in
   Korean adults
SO GENES AND NUTRITION
LA English
DT Article
DE APOA5; Metabolic syndrome; Single nucleotide polymorphism (SNP);
   Genome-wide association study (GWAS); Red and processed meat; Korean
   Genome and Epidemiology Study (KoGES)
ID CORONARY-HEART-DISEASE; APOLIPOPROTEIN A-V; RISK; MORTALITY; HEALTH
AB Background Metabolic syndrome (MetS) is characterized by the coexistence of disorders such as diabetes, hypertension, hyperlipidemia, and obesity and is affected by genetic factors. Previous genome-wide association studies (GWAS) suggested that APOA5 gene variants were significantly associated with MetS and its components. Dietary factors such as red and processed meat consumption can cause chronic diseases, including hypertension, diabetes, and vascular depression. The aim of this study was to investigate the modulation of the incidence of MetS by the interaction between APOA5 rs662799 polymorphism and red and processed meat consumption. Methods In this prospective cohort study, 3266 participants were collected from the Korea Association REsource (KARE) cohort of the Korean Genome and Epidemiology Study (KoGES) from 2001 to 2016. APOA5 rs662799 polymorphism was extracted by GWAS using the Korean Chip. Red and processed meat consumption data were assessed using a semi-quantitative food frequency questionnaire. Results The incidence of MetS in carriers of the minor G allele of rs662799 (AG + GG) and the third tertile of red and processed meat consumption (serving/day) was higher than those with the major allele of rs662799 (AA) and the first tertile of red and processed meat consumption (HR 1.70, 95% CI 1.30-2.22, p interaction = 0.002). Conclusions An association between the presence of the minor alleles of rs662799 and high red and processed meat consumption and the incidence of MetS was observed in Korean adults.
C1 [Choi, Woo Jeong; Shin, Dayeon] Inha Univ, Dept Food & Nutr, 100 Inha Ro, Incheon 22212, South Korea.
C3 Inha University
RP Shin, D (corresponding author), Inha Univ, Dept Food & Nutr, 100 Inha Ro, Incheon 22212, South Korea.
EM dyshin@inha.ac.kr
RI Shin, Dayeon/GMX-2004-2022
OI Shin, Dayeon/0000-0003-0828-184X
FU National Research Foundation of Korea (NRF) - Korean government (MSIT)
   [2020R1G1A1004940]
FX This work was supported by the National Research Foundation of Korea
   (NRF) grant funded by the Korean government (MSIT) (Grant No.
   2020R1G1A1004940).
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NR 40
TC 3
Z9 4
U1 0
U2 3
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1555-8932
EI 1865-3499
J9 GENES NUTR
JI Genes Nutr.
PD DEC
PY 2022
VL 17
IS 1
AR 5
DI 10.1186/s12263-022-00707-w
PG 14
WC Genetics & Heredity; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Genetics & Heredity; Nutrition & Dietetics
GA 0T9QX
UT WOS:000787296800001
PM 35468744
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Endo, Y
   Tabara, Y
   Kawaguchi, T
   Onoufriadis, A
   McGrath, JA
   Matsuda, F
   Kabashima, K
AF Endo, Yuichiro
   Tabara, Yasuharu
   Kawaguchi, Takahisa
   Onoufriadis, Alexandros
   McGrath, John A.
   Matsuda, Fumihiko
   Kabashima, Kenji
CA Nagahama Study Grp
TI Metabolic syndrome and comorbidities in patients with psoriasis: a
   community-based case-control study from the Nagahama cohort in Japan
SO EUROPEAN JOURNAL OF DERMATOLOGY
LA English
DT Article
DE Community-based cohort; comorbidities; Japan; metabolic syndrome (MetS);
   psoriasis
ID OBSTRUCTIVE PULMONARY-DISEASE; ATOPIC-DERMATITIS; PREVALENCE;
   ONYCHOMYCOSIS; EPIDEMIOLOGY; METAANALYSIS; ASSOCIATION; DEPRESSION;
   ONSET
AB Background Psoriasis is reported to be associated with systemic diseases, such as metabolic syndrome (MetS), which is related to high blood pressure, hyperglycaemia, obesity and dyslipidaemia. However, clinical factors associated with psoriasis in the general population have not been fully elucidated. Objectives To explore the clinical factors associated with psoriasis by analysing a dataset of community-based cohort studies Materials & Methods The study participants consisted of 9,183 apparently healthy community residents in Japan (mean age: 64.5 +/- 10.7 years). The clinical parameters used in this study were obtained from a baseline investigation performed between 2008 and 2010. The history of psoriasis was queried using a structured questionnaire Results A total of 335 participants (3.6%) had a history of psoriasis. The psoriasis group was older (64.5 +/- 10.7 vs 57.9 +/- 12.3 years; p < 0.001) and mostly male (43.9 vs 33.0 %, p < 0.001) compared to the non-psoriasis group. Based on univariate analysis, the prevalence of MetS was higher in the psoriasis group (19.1 vs 13.6%, odds ratio = 1.50, p = 0.004), although this association disappeared after adjustment for age and sex. Similar results were observed based on the analysis of each MetS component. Other factors associated with psoriasis were history of tinea pedis (age-and sex-adjusted odds ratio = 5.27), gout (1.97), chronic obstructive pulmonary disease (5.83), reflux oesophagitis (1.72) and depressive symptoms (1.57). After further adjustment for potential covariates, the associations with these factors remained significant. Conclusion Several chronic conditions associated with psoriasis in the general population were identified
C1 [Endo, Yuichiro; Kabashima, Kenji] Kyoto Univ, Dept Dermatol, Kyoto, Japan.
   [Endo, Yuichiro; Onoufriadis, Alexandros; McGrath, John A.] Kings Coll London, St Johns Inst Dermatol, Sch Basic & Med Biosci, London, England.
   [Tabara, Yasuharu; Kawaguchi, Takahisa; Matsuda, Fumihiko] Kyoto Univ, Ctr Genom Med, Kyoto, Japan.
C3 Kyoto University; University of London; King's College London; Kyoto
   University
RP Endo, Y (corresponding author), Kyoto Univ, Dept Dermatol, Kyoto, Japan.; Endo, Y (corresponding author), Kings Coll London, St Johns Inst Dermatol, Sch Basic & Med Biosci, London, England.
EM endo@kuhp.kyoto-u.ac.jp
RI McGrath, John/N-3529-2019; Kabashima, Kenji/G-2521-2014; McGrath,
   John/D-6824-2012
OI Onoufriadis, Alexandros/0000-0001-5026-0431; McGrath,
   John/0000-0002-3708-9964
FU Ministry of Education, Culture, Sports, Science and Technology in Japan;
   Centre of Innovation Programme from Japan Science and Technology Agency;
   Global University Project from Japan Science and Technology Agency;
   Japan Agency for Medical Research and Development (AMED); Grants-in-Aid
   for Scientific Research [21H04850] Funding Source: KAKEN
FX this study was supported by the following grants: University Grants and
   Grant-in-Aid for Scientific Research from the Ministry of Education,
   Culture, Sports, Science and Technology in Japan; The Centre of
   Innovation Programme and the Global University Project from Japan
   Science and Technology Agency; and The Practical Research Project for
   Rare/Intractable Diseases and Comprehensive Research on Ageing and
   Health Science Research Grants for Dementia R&D from the Japan Agency
   for Medical Research and Development (AMED).
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NR 50
TC 1
Z9 1
U1 0
U2 4
PU JLE
PI ARCUEIL
PA 30, RUE BERTHOLLET, BATIMENT A, 94110 ARCUEIL, ?, FRANCE
SN 1167-1122
EI 1952-4013
J9 EUR J DERMATOL
JI Eur. J. Dermatol.
PD JAN
PY 2022
VL 32
IS 1
BP 86
EP 93
DI 10.1684/ejd.2022.4231
PG 8
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 1X5KU
UT WOS:000807493300010
PM 35514103
DA 2025-06-11
ER

PT J
AU Przepiera-Bedzak, H
   Fischer, K
   Brzosko, M
AF Przepiera-Bedzak, Hanna
   Fischer, Katarzyna
   Brzosko, Marek
TI Serum interleukin-23 protects, whereas methotrexate treatment stimulates
   selected components of the metabolic syndrome in patients with SAPHO
   syndrome
SO ARCHIVES OF MEDICAL SCIENCE
LA English
DT Article
DE interleukin-23; lipid profile; metabolic syndrome; methotrexate; SAPHO
ID SINGLE-CENTER; PSORIATIC-ARTHRITIS; OSTEITIS SYNDROME; HYPEROSTOSIS;
   PUSTULOSIS; ACNE; PREVALENCE; SYNOVITIS; DISEASE; COHORT
AB Introduction: The aim of the study was to evaluate the impact of disease activity, selected serum cytokines, and therapy on metabolic syndrome (MetS) components in patients with synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome.
   Material and methods: We studied 46 SAPHO patients (40 women, 6 men). We recorded age, sex, disease duration, arthritis localization, type of skin changes, bone scintigraphy results, comorbidities, BASDAI, VAS, and treatment. We measured erythrocyte sedimentation rate, C-reactive protein, lipid profile, serum IL-6, IL-18, IL-23, endothelin-1, vascular endothelial growth factor, and epidermal growth factor (EGF).
   Results: 97.8% of patients had sternoclavicular joint arthritis, 91.3% of patients palmoplantar pustulosis. In 65.2% of SAPHO patients skin changes and arthritis started simultaneously. Apart from non-steroidal anti-inflammatory drugs, patients were treated with methotrexate (41.3%), sulfasalazine (41.3%), and antibiotics (39.1%). 19.5% of patients met MetS criteria. Serum IL-23 correlated positively with total cholesterol (TC; p = 0.02) and high-density lipoprotein cholesterol (HDL-C) (p = 0.01) in the SAPHO group. There was a negative correlation between HDL-C and BASDAI (p = 0.02). Patients treated with methotrexate had higher triglyceride (p = 0.01) and low-density lipoprotein cholesterol (LDL-C) (p = 0.01) levels. There was a negative correlation between TC and EGF (p = 0.03). Increased prevalence of autoimmune diseases and depression was observed in SAPHO patients.
   Conclusions: Serum IL-23 protects, whereas methotrexate treatment stimulates selected components of the MetS in patients with SAPHO syndrome.
C1 [Przepiera-Bedzak, Hanna; Brzosko, Marek] Pomeranian Med Univ, Dept Rheumatol Internal Med & Geriatr, 1 Unii Lubelskiej St, PL-71252 Szczecin, Poland.
   [Fischer, Katarzyna] Pomeranian Med Univ, Independent Lab Rheumat Diagnost, Szczecin, Poland.
C3 Pomeranian Medical University; Pomeranian Medical University
RP Przepiera-Bedzak, H (corresponding author), Pomeranian Med Univ, Dept Rheumatol Internal Med & Geriatr, 1 Unii Lubelskiej St, PL-71252 Szczecin, Poland.
EM hannapb@pum.edu.pl
RI Fischer, Katarzyna/AAL-1282-2020; Przepiera-Bedzak, Hanna/A-5443-2015
FU National Science Centre in Poland [DEC-2011/03/B/NZ5/04192]
FX This work was supported by a grant from the National Science Centre in
   Poland (DEC-2011/03/B/NZ5/04192).
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NR 37
TC 7
Z9 7
U1 0
U2 1
PU TERMEDIA PUBLISHING HOUSE LTD
PI POZNAN
PA KLEEBERGA ST 2, POZNAN, 61-615, POLAND
SN 1734-1922
EI 1896-9151
J9 ARCH MED SCI
JI Arch. Med. Sci.
PY 2021
VL 17
IS 1
BP 120
EP 126
DI 10.5114/aoms.2018.76953
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA QD5TT
UT WOS:000615581000016
PM 33488864
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Weerarathna, TP
   Lekamwasam, S
   Kodikara, I
   Wasana, KGP
   Fonseka, L
AF Weerarathna, Thilak Priyantha
   Lekamwasam, Sarath
   Kodikara, Iroshani
   Wasana, Keddegoda Gamage Piyumi
   Fonseka, Lakmal
TI Control of cardiometabolic risk factors and their association with
   carotid intima media thickness among patients with type 2 diabetes
   mellitus-single center experience in a developing country
SO TURKISH JOURNAL OF MEDICAL SCIENCES
LA English
DT Article
DE Atherosclerotic cardiovascular diseases; cardiometabolic risk factors;
   carotid intima-media thickness; type 2 diabetes mellitus
ID FATTY LIVER-DISEASE; CARDIOVASCULAR-DISEASE; OXIDATIVE STRESS; GLYCEMIC
   CONTROL; GUT MICROBIOTA; SOUTH ASIANS; EVENTS; INDIVIDUALS; CHOLESTEROL;
   MECHANISMS
AB Background/aim: Type 2 diabetes mellitus (T2DM) is closely associated with atherosclerotic cardiovascular diseases (ASCVD). The objective of this study was to describe the degree of ASCVD risk factor control and their association with carotid intima-media thickness (CIMT) in T2DM patients followed up at a diabetes clinic in Southern, Sri Lanka. Materials and methods: A crosssectional study was conducted to examine the association between CIMT and nonalcoholic fatty liver disease (NAFLD)in 300 T2DM patients. Both CIMT and its associations with modifiable cardiometabolic risk factors were examined using ultrasonography. The recommended optimal targets for risk factors were defined as glycated hemoglobin (HbA 1C ) < 7 %, absence of NAFLD, albumin-to-creatinine ratio (ACR) < 30 mg, triglyceride (TG) < 150 mg/dL, low -density lipoprotein cholesterol (LDL-C) < 100 mg/dL, high -density lipoprotein cholesterol (HDL-C) in men > 40 and in women > 50 mg/dL, systolic blood pressure (SBP) < 130 mmHg, and diastolic blood pressure (DBP) < 80 mmHg. Results: SBP, DBP, LDL-C, TG, HDL-C, HbA 1C , and ACR were optimally controlled in 59.3%, 75.0%, 46.7%, 84.3%, 46.0%, 33.0%, and 18.7% of patients, respectively. Notably, nearly half of the study subjects did not have NAFLD. Only three patients (1%) had achieved all therapeutic targets. There were statistically significant differences in CIMT between optimally controlled TG and suboptimally controlled TG group (p = 0.027) and between the groups with and without NAFLD (p = 0.045) when adjusted for age and duration of diabetes. CIMT showed significant and positive associations with LDL-C (p = 0.024), TG (p = 0.026), and NAFLD (p = 0.005). Among these, the presence of NAFLD had the highest odds of having higher CIMT when compared to LDL-C and TG. Conclusion: The majority of patients have not achieved the recommended targets for ASCVD risk factors and are at high risk of ASCVD. It is therefore necessary to identify the reasons for not achieving the treatment targets in order to reduce the ASCVD burden by controlling LDL-C, TG, and NAFLD.
C1 [Weerarathna, Thilak Priyantha; Lekamwasam, Sarath; Fonseka, Lakmal] Univ Ruhuna, Fac Med, Dept Med, Galle, Sri Lanka.
   [Kodikara, Iroshani] Univ Ruhuna, Fac Med, Dept Anat, Galle, Sri Lanka.
   [Wasana, Keddegoda Gamage Piyumi] Cooperat Hosp, Diabet Ctr, Galle, Sri Lanka.
C3 University Ruhuna; University Ruhuna
RP Weerarathna, TP (corresponding author), Univ Ruhuna, Fac Med, Dept Med, Galle, Sri Lanka.
EM thilak.priyantha@yahoo.com
RI Kodikara, Iroshani/ABC-7143-2021
FX Acknowledgment/disclaimers We would like to express our gratitude to the
   nursing and supporting staff of the University Medical Clinic at the
   Teaching Hospital Karapitiya, Southern, Sri Lanka, for their support
   during the study.
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NR 49
TC 0
Z9 0
U1 0
U2 1
PU Tubitak Scientific & Technological Research Council Turkey
PI ANKARA
PA ATATURK BULVARI NO 221, KAVAKLIDERE, TR-06100 ANKARA, TURKIYE
SN 1300-0144
EI 1303-6165
J9 TURK J MED SCI
JI Turk. J. Med. Sci.
PY 2024
VL 54
IS 3
DI 10.55730/1300-0144.5821
PG 11
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA UT5T0
UT WOS:001250329000008
PM 39050007
OA hybrid
DA 2025-06-11
ER

PT J
AU Chen, J
   Patschan, S
   Goligorsky, MS
AF Chen, Jun
   Patschan, Susann
   Goligorsky, Michael S.
TI Stress-induced premature senescence of endothelial cells
SO JOURNAL OF NEPHROLOGY
LA English
DT Review
DE Endothelium; Macrovasculopathy; Metabolic syndrome; Microvasculopathy;
   Stress induced premature senescence
ID GLYCATION END-PRODUCTS; PLASMINOGEN-ACTIVATOR INHIBITOR; HUMAN-DIPLOID
   FIBROBLASTS; CELLULAR SENESCENCE; OXIDATIVE STRESS; REPLICATIVE
   SENESCENCE; DNA-DAMAGE; DIABETIC COMPLICATIONS; OXIDANT STRESS; GROWTH
   ARREST
AB Stress-induced premature senescence (SIPS):is characterized by cell cycle arrest and curtailed Hayflick limit. Studies support a central role for Rb protein in controlling this process via signaling from the p53 and p16 pathways. Cellular senescence is considered, an., essential contributor to the aging process and has been shown to be an important tumor suppression mechanism. In addition, emerging evidence suggests that. SIPS may be involved in the pathogenesis of chronic human., diseases. Here, focusing on endothelial cells, we discuss recent advances in our understanding of SIPS and the pathways that trigger it, evaluate their correlation with the apoptotic response and examine their links to the development of chronic diseases, with the emphasis on vasculopathy. Emerging novel therapeutic interventions based on recent experimental findings are also reviewed.
C1 New York Med Coll, Renal Res Inst, Dept Med, Valhalla, NY 10595 USA.
   New York Med Coll, Renal Res Inst, Dept Pharmacol, Valhalla, NY 10595 USA.
C3 Renal Research Institute; New York Medical College; New York Medical
   College; Renal Research Institute
RP Goligorsky, MS (corresponding author), New York Med Coll, Renal Res Inst, Dept Med, Valhalla, NY 10595 USA.
EM Michael_goligorsky@nymc.edu
FU NIDDK NIH HHS [DK54602, DK45462, DK52783] Funding Source: Medline
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NR 87
TC 25
Z9 28
U1 2
U2 7
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1121-8428
EI 1724-6059
J9 J NEPHROL
JI J. Nephrol.
PD MAY-JUN
PY 2008
VL 21
IS 3
BP 337
EP 344
PG 8
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 405SO
UT WOS:000263244700010
PM 18587721
DA 2025-06-11
ER

PT J
AU Zarrouki, B
   Soares, AF
   Guichardant, M
   Lagarde, M
   Géloën, A
AF Zarrouki, B.
   Soares, A. F.
   Guichardant, M.
   Lagarde, M.
   Geloen, A.
TI The lipid peroxidation end-product 4-HNE induces COX-2 expression
   through p38MAPK activation in 3T3-L1 adipose cell
SO FEBS LETTERS
LA English
DT Article
DE oxidative stress; 4-hydroxy-2-nonenal; cyclooxygenase; p38MAPK;
   adipocyte; 3T3-L1
ID OXIDATIVE STRESS; METABOLIC SYNDROME; CYCLOOXYGENASE-2; INFLAMMATION;
   ADIPOCYTES; IMPACT; OBESE
AB Oxidative stress and low grade chronic inflammation are increased in accumulating fat. Our objective was to test whether 4-hydroxynonenal (4-HNE), an end-product of lipid peroxidation, affects cyclooxygenases in 3T3-L1 adipose cells. 4-HNE increased COX-2 mRNA and protein expression and p38MAP-kinase phosphorylation in a dose-dependent manner. Pretreatment of 3T3-L1 cells by a selective inhibitor of p38MAPK (PD 169316) abolished 4-HNE and glucose oxidase induced COX-2 expression.
   Our results show that oxidative stress induces COX-2 expression through the production of 4-HNE which activates p38MAP-Kinase, suggesting that 4-HNE links oxidative stress and chronic inflammation through the activation of cyclooxygenase. (c) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
C1 [Zarrouki, B.; Soares, A. F.; Guichardant, M.; Lagarde, M.; Geloen, A.] Inst Natl Sci Appl, INSERM, UMR 870, 11 Ave J Capelle, F-69621 Villeurbanne, France.
   [Zarrouki, B.; Soares, A. F.; Guichardant, M.; Lagarde, M.; Geloen, A.] Univ Lyon, F-69008 Lyon, France.
   [Zarrouki, B.; Soares, A. F.; Guichardant, M.; Lagarde, M.; Geloen, A.] INSERM U870, F-69008 Lyon, France.
   [Zarrouki, B.; Soares, A. F.; Guichardant, M.; Lagarde, M.; Geloen, A.] INRA, U1235, F-69008 Lyon, France.
   [Zarrouki, B.; Soares, A. F.; Guichardant, M.; Lagarde, M.; Geloen, A.] Univ Lyon 1, F-69003 Lyon, France.
   [Zarrouki, B.; Soares, A. F.; Guichardant, M.; Lagarde, M.; Geloen, A.] Hospices Civils Lyon, F-69003 Lyon, France.
C3 Institut National des Sciences Appliquees de Lyon - INSA Lyon; Institut
   National de la Sante et de la Recherche Medicale (Inserm); Institut
   National de la Sante et de la Recherche Medicale (Inserm); INRAE;
   Universite Claude Bernard Lyon 1; Universite Claude Bernard Lyon 1; CHU
   Lyon
RP Géloën, A (corresponding author), Inst Natl Sci Appl, INSERM, UMR 870, 11 Ave J Capelle, F-69621 Villeurbanne, France.
EM alain.geloen@insa-lyon.fr
RI SOARES, ANÍSIO/AAS-6950-2021; GELOEN, Alain/D-6725-2011
OI SOARES, ANISIO FRANCISCO/0000-0003-1493-7964; GELOEN,
   Alain/0000-0001-7921-1254
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NR 17
TC 59
Z9 66
U1 0
U2 8
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0014-5793
EI 1873-3468
J9 FEBS LETT
JI FEBS Lett.
PD MAY 29
PY 2007
VL 581
IS 13
BP 2394
EP 2400
DI 10.1016/j.febslet.2007.04.048
PG 7
WC Biochemistry & Molecular Biology; Biophysics; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Cell Biology
GA 176LW
UT WOS:000247087600003
PM 17481611
DA 2025-06-11
ER

PT J
AU Demirkol, S
   Balta, S
   Celik, T
   Arslan, Z
   Unlu, M
   Cakar, M
   Kucuk, U
   Demirbas, S
   Iyisoy, A
   Yokusoglu, M
AF Demirkol, Sait
   Balta, Sevket
   Celik, Turgay
   Arslan, Zekeriya
   Unlu, Murat
   Cakar, Mustafa
   Kucuk, Ugur
   Demirbas, Seref
   Iyisoy, Atila
   Yokusoglu, Mehmet
TI Assessment of the relationship between red cell distribution width and
   cardiac syndrome X
SO KARDIOLOGIA POLSKA
LA English
DT Article
DE cardiac syndrome X; red cell distribution width; endothelial dysfunction
ID C-REACTIVE PROTEIN; CHEST-PAIN; INFLAMMATION; DISEASE; ATHEROSCLEROSIS
AB Background: Cardiac syndrome X (CSX) is characterised by angina-like chest pain, a positive stress test, and normal coronary arteries. Increased red cell distribution width (RDW) level may be indicative of an underlying inflammatory state.
   Aim: To investigate RDW level in patients with CSX and compare patients having coronary artery disease (CAD) and normal subjects.
   Methods: 245 subjects (79 patients with CSX, 81 patients with CAD, and 85 controls) were enrolled in the study. The CSX group consisted of patients with anginal chest pain, ischaemia on noninvasive stress test and a normal coronary angiogram. CAD was defined as >= 50% stenosis in at least one coronary artery. The control group was selected from the patients with anginal symptoms but a normal stress test and a normal coronary angiogram. RDW measurements among the three groups were compared.
   Results: Baseline clinical and biochemical characteristics were not different among the three groups. There were no statistically significant differences in RDW levels between the CSX and CAD groups (p = 0.17). RDW measurements in both the CSX and CAD groups were found to be significantly higher than the control group (p < 0.01).
   Conclusions: We discovered that patients with CSX and CAD have significantly higher RDW measurements compared to controls. The relationship between CSX and higher RDW level suggests that endothelial dysfunction may also contribute to the etiopathogenesis of the CSX phenomenon as it does with CAD.
C1 [Demirkol, Sait; Balta, Sevket; Celik, Turgay; Kucuk, Ugur; Iyisoy, Atila; Yokusoglu, Mehmet] Gulhane Mil Med Acad, Sch Med, Dept Cardiol, Etlik, Turkey.
   [Arslan, Zekeriya] Gelibolu Hosp, Dept Cardiol, Canakkale, Turkey.
   [Unlu, Murat] Beytepe Hosp, Dept Cardiol, Ankara, Turkey.
   [Cakar, Mustafa; Demirbas, Seref] Gulhane Mil Med Acad, Sch Med, Dept Internal Med, Etlik, Turkey.
C3 Gulhane Military Medical Academy; Gelibolu State Hospital; Ankara
   Beytepe Murat Erdi Eker State Hospital; Gulhane Military Medical Academy
RP Demirkol, S (corresponding author), Gulhane Mil Med Acad, Dept Cardiol, Tevfik Saglam St, TR-06018 Etlik, Turkey.
EM saitdemirkol@yahoo.com
RI Çakar, Mustafa/Y-1380-2019; Celik, Turgay/I-2981-2019
OI Arslan, Zekeriya/0000-0003-1497-1396; Balta, Sevket/0000-0002-6657-7334;
   Celik, Turgay/0000-0001-8418-0130
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NR 17
TC 38
Z9 42
U1 0
U2 4
PU VIA MEDICA
PI GDANSK
PA UL SWIETOKRZYSKA 73, 80-180 GDANSK, POLAND
SN 0022-9032
J9 KARDIOL POL
JI Kardiol. Pol.
PY 2013
VL 71
IS 5
BP 480
EP 484
DI 10.5603/KP.2013.0094
PG 5
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 169KM
UT WOS:000320779000007
PM 23788088
OA hybrid
DA 2025-06-11
ER

PT J
AU De Blasio, A
   D'Anneo, A
   Lauricella, M
   Emanuele, S
   Giuliano, M
   Pratelli, G
   Calvaruso, G
   Carlisi, D
AF De Blasio, Anna
   D'Anneo, Antonella
   Lauricella, Marianna
   Emanuele, Sonia
   Giuliano, Michela
   Pratelli, Giovanni
   Calvaruso, Giuseppe
   Carlisi, Daniela
TI The Beneficial Effects of Essential Oils in Anti-Obesity Treatment
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE obesity; metabolic syndrome; essential oils
ID BROWN ADIPOSE-TISSUE; DE-NOVO LIPOGENESIS; GUT MICROBIOTA;
   SALVIA-OFFICINALIS; INSULIN-RESISTANCE; OLFACTORY STIMULATION;
   LIPID-METABOLISM; CUMINUM-CYMINUM; BINDING PROTEIN; MEDICINAL-PLANT
AB Obesity is a complex disease caused by an excessive amount of body fat. Obesity is a medical problem and represents an important risk factor for the development of serious diseases such as insulin resistance, type 2 diabetes, cardiovascular disease, and some types of cancer. Not to be overlooked are the psychological issues that, in obese subjects, turn into very serious pathologies, such as depression, phobias, anxiety, and lack of self-esteem. In addition to modifying one's lifestyle, the reduction of body mass can be promoted by different natural compounds such as essential oils (EOs). EOs are mixtures of aromatic substances produced by many plants, particularly in medicinal and aromatic ones. They are odorous and volatile and contain a mixture of terpenes, alcohols, aldehydes, ketones, and esters. Thanks to the characteristics of the various chemical components present in them, EOs are used in the food, cosmetic, and pharmaceutical fields. Indeed, it has been shown that EOs possess great antibiotic, anti-inflammatory, and antitumor powers. Emerging results also demonstrate the anti-obesity effects of EOs. We have examined the main data obtained in experimental studies and, in this review, we summarize the effect of EOs in obesity and obesity-related metabolic diseases.
C1 [De Blasio, Anna; D'Anneo, Antonella; Giuliano, Michela; Calvaruso, Giuseppe] Univ Palermo, Dept Biol Chem & Pharmaceut Sci & Technol STEBICE, Lab Biochem, I-90127 Palermo, Italy.
   [Lauricella, Marianna; Emanuele, Sonia; Pratelli, Giovanni; Carlisi, Daniela] Univ Palermo, Inst Biochem, Dept Biomed Neurosci & Adv Diagnost BIND, I-90127 Palermo, Italy.
C3 University of Palermo; University of Palermo
RP Lauricella, M; Carlisi, D (corresponding author), Univ Palermo, Inst Biochem, Dept Biomed Neurosci & Adv Diagnost BIND, I-90127 Palermo, Italy.
EM anna.deblasio@unipa.it; antonella.danneo@unipa.it;
   marianna.lauricella@unipa.it; sonia.emanuele@unipa.it;
   michela.giuliano@unipa.it; giovanni.pratelli@unipa.it;
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RI D’Anneo, Antonella/P-1064-2019; Lauricella, Marianna/ABD-1263-2020
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NR 160
TC 29
Z9 29
U1 7
U2 39
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD NOV
PY 2021
VL 22
IS 21
AR 11832
DI 10.3390/ijms222111832
PG 21
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA XB2OO
UT WOS:000721171700001
PM 34769261
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Wysokinski, A
   Socha, K
   Soltysik, BK
   Kloszewska, I
   Sobów, T
   Kostka, T
AF Wysokinski, Adam
   Socha, Krzysztof
   Soltysik, Bartlomiej Konrad
   Kloszewska, Iwona
   Sobow, Tomasz
   Kostka, Tomasz
TI Levels of C-reactive protein (CRP) in elderly patients with unipolar
   depression - case control analysis
SO NORDIC JOURNAL OF PSYCHIATRY
LA English
DT Article
DE CRP; C-reactive protein; depression; elderly; old age psychiatry
ID CORONARY-HEART-DISEASE; BIPOLAR DISORDER; CARDIOVASCULAR RISK; METABOLIC
   SYNDROME; MENTAL-ILLNESS; SCHIZOPHRENIA; INFLAMMATION; ASSOCIATION;
   POPULATION; SYMPTOMS
AB Aim: C-reactive protein (CRP) is the major acute-phase plasma protein. Studies show that patients with depression have elevated levels of CRP. The aim of the study was to determine differences in CRP serum level in elderly patients with unipolar depression (DEP) compared with non-depressed elderly patients (nonDEP) using case-control analysis.Methods: Serum level of CRP was measured in 404 (DEP: n=202, nonDEP: n=202) Caucasian inpatients aged 60 (350 women, 86.7%; mean age=76.7 years).Results: Mean CRP level in the study groups was: DEP 2.672.56mg/dL, nonDEP 2.41 +/- 2.19mg/dL, the difference was not significant (p=0.96). The overall rate of being above the high level of CRP (set at 3.0mg/L) was 33.2% for DEP and 29.2% for nonDEP groups (p=0.39). It was also found that, in the whole study group, CRP level was not correlated with age (p=0.10).Conclusions: Elderly patients with depression have no increased CRP levels. A high percentage (approximate to 30%) of all subjects had a CRP level >3mg/L, which is the cut-off point for increased cardiovascular risk.
C1 [Wysokinski, Adam; Kloszewska, Iwona] Med Univ Lodz, Dept Old Age Psychiat & Psychot Disorders, Czechoslowacka 8-10, PL-92216 Lodz, Poland.
   [Socha, Krzysztof; Soltysik, Bartlomiej Konrad; Kostka, Tomasz] Med Univ Lodz, Dept Geriatr, Lodz, Poland.
   [Sobow, Tomasz] Med Univ Lodz, Dept Med Psychol, Lodz, Poland.
C3 Medical University Lodz; Medical University Lodz; Medical University
   Lodz
RP Wysokinski, A (corresponding author), Med Univ Lodz, Dept Old Age Psychiat & Psychot Disorders, Czechoslowacka 8-10, PL-92216 Lodz, Poland.
EM adam.wysokinski@umed.lodz.pl
RI Wysokinski, Adam/S-9294-2016; Wysokinski, Adam/G-8174-2014; Soltysik,
   Bartlomiej K./S-9839-2016
OI Wysokinski, Adam/0000-0002-6159-6579; Soltysik, Bartlomiej
   K./0000-0002-1382-3757; Kostka, Tomasz/0000-0003-0437-650X
FU Healthy Ageing Research Center [REGPOT-2012-2013-1, 7FP]
FX The authors are (partially) supported by the Healthy Ageing Research
   Center (REGPOT-2012-2013-1, 7FP).
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NR 49
TC 4
Z9 4
U1 0
U2 9
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0803-9488
EI 1502-4725
J9 NORD J PSYCHIAT
JI Nord. J. Psychiatr.
PD OCT
PY 2016
VL 70
IS 7
BP 503
EP 507
DI 10.3109/08039488.2016.1174298
PG 5
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA DV6IK
UT WOS:000383037300004
PM 27117065
DA 2025-06-11
ER

PT J
AU Birnbaum-Weitzman, O
   Goldberg, R
   Hurwitz, BE
   Llabre, MM
   Gellman, MD
   Gutt, M
   McCalla, JR
   Mendez, AJ
   Schneiderman, N
AF Birnbaum-Weitzman, O.
   Goldberg, R.
   Hurwitz, B. E.
   Llabre, M. M.
   Gellman, M. D.
   Gutt, M.
   McCalla, J. R.
   Mendez, A. J.
   Schneiderman, N.
TI Depressive symptoms linked to 1-h plasma glucose concentrations during
   the oral glucose tolerance test in men and women with the metabolic
   syndrome
SO DIABETIC MEDICINE
LA English
DT Article
ID INSULIN-RESISTANCE; RISK; METAANALYSIS; ASSOCIATION; SENSITIVITY;
   INDIVIDUALS; PREVALENCE; INVENTORY; INDEXES
AB Aims
   The addition of the 1-h plasma glucose concentration measure from an oral glucose tolerance test to prediction models of future Type2 diabetes has shown to significantly strengthen their predictive power. The present study examined the relationship between severity of depressive symptoms and hyperglycaemia, focusing on the 1-h glucose concentration vs. fasting and 2-h glucose measures from the oral glucose tolerance test.
   Methods
   Participants included 140 adults with the metabolic syndrome and without diabetes who completed a baseline psychobiological assessment and a 2-h oral glucose tolerance test, with measurements taken every 30min. Depressive symptoms were assessed using the Beck Depression Inventory.
   Results
   Multivariate linear regression revealed that higher levels of depressive symptoms were associated with higher levels of 1-h plasma glucose concentrations after adjusting for age, gender, ethnicity, BMI, antidepressant use and high-sensitivity C-reactive protein.
   Results were maintained after controlling for fasting glucose as well as for indices of insulin resistance and secretion. Neither fasting nor 2-h plasma glucose concentrations were significantly associated with depressive symptoms.
   Conclusions
   Elevated depressive symptoms in persons with the metabolic syndrome were associated with greater glycaemic excursion 1-h following a glucose load that was not accounted for by differences in insulin secretory function or insulin sensitivity. Consistent with previous findings, this study highlights the value of the 1-h plasma glucose measurement from the oral glucose tolerance test in the relation between depressive symptoms and glucose metabolism as an indicator of metabolic abnormalities not visible when focusing on fasting and 2-h post-oral glucose tolerance test measurements alone.
C1 [Birnbaum-Weitzman, O.; Hurwitz, B. E.; Llabre, M. M.; Gellman, M. D.; Schneiderman, N.] Univ Miami, Behav Med Res Ctr, Miami, FL 33136 USA.
   [Birnbaum-Weitzman, O.; Hurwitz, B. E.; Llabre, M. M.; Gellman, M. D.; McCalla, J. R.; Schneiderman, N.] Univ Miami, Dept Psychol, Miami, FL USA.
   [Goldberg, R.; Hurwitz, B. E.; Gutt, M.; Mendez, A. J.; Schneiderman, N.] Univ Miami, Dept Med, Div Endocrinol & Metab, Miami, FL USA.
   [Goldberg, R.; Mendez, A. J.] Univ Miami, Diabet Res Inst, Miami, FL USA.
   [Schneiderman, N.] Univ Miami, Dept Psychiat & Behav Sci, Miami, FL USA.
C3 University of Miami; University of Miami; University of Miami;
   University of Miami; University of Miami
RP Birnbaum-Weitzman, O (corresponding author), Univ Miami, Behav Med Res Ctr, Miami, FL 33136 USA.
EM oweitzman@miami.edu
RI Mendez, Armando/HQY-1723-2023
FU National Heart, Lung and Blood Institute (NHLBI) Behavioral Medicine in
   Cardiovascular Disease Research Training Grant [T32HL007426-33];
   National Heart, Lung and Blood Institute (NHLBI) Biobehavioral Bases of
   CHD Risk and Management Program Project grant [HL36588]
FX This study was supported by National Heart, Lung and Blood Institute
   (NHLBI) Behavioral Medicine in Cardiovascular Disease Research Training
   Grant (T32HL007426-33) and Biobehavioral Bases of CHD Risk and
   Management Program Project grant (HL36588).
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NR 30
TC 3
Z9 3
U1 0
U2 8
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0742-3071
EI 1464-5491
J9 DIABETIC MED
JI Diabetic Med.
PD MAY
PY 2014
VL 31
IS 5
BP 630
EP 636
DI 10.1111/dme.12356
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA AE6QD
UT WOS:000334117700019
PM 24344735
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Verhoeven, V
   Van der Auwera, A
   Van Gaal, L
   Remmen, R
   Apers, S
   Stalpaert, M
   Wens, J
   Hermans, N
AF Verhoeven, Veronique
   Van der Auwera, Anastasia
   Van Gaal, Luc
   Remmen, Roy
   Apers, Sandra
   Stalpaert, Michel
   Wens, Johan
   Hermans, Nina
TI Can red yeast rice and olive extract improve lipid profile and
   cardiovascular risk in metabolic syndrome?: a double blind, placebo
   controlled randomized trial
SO BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Article
DE Cardiovascular prevention; Metabolic syndrome; Statins; Red yeast rice;
   Olive; Cholesterol
ID LOW-DENSITY-LIPOPROTEIN; PHOTODIODE-ARRAY DETECTOR; OXIDATIVE STRESS;
   BLOOD-PRESSURE; MEDITERRANEAN DIET; STATIN THERAPY; CHOLESTEROL;
   OBESITY; DISEASE; INFLAMMATION
AB Background: Metabolic syndrome (MetS) comprises a spectrum of clinical phenotypes in which dyslipidemia, dysglycemia and hypertension are clustered and where all share a high level of oxidative stress and an increased risk of cardiovascular disease. This study examines the effect of a nutritional supplement combining red yeast rice and olive fruit extract on the lipid profile and on oxidative stress in a population of patients with MetS.
   Methods: In a double blind placebo controlled randomized trial, 50 persons with MetS, as defined by the ATPIII criteria, received the study product or placebo for 8 weeks. The study product contained 10.82 mg of monacolins and 9,32 mg of hydroxytyrosol per capsule, and is commercialized as Cholesfytol plus. The primary outcome measure was the difference in LDL reduction between intervention and control groups. Furthermore, differences in changes of CH, HDL, ApoA1, ApoB, HbA1c and oxLDL were measured, as well as side-effects, CK elevation, changes in clinical parameters and in cardiovascular risk.
   Results: In the intervention group, LDL cholesterol was lowered by 24% whereas it increased by 1% in the control group (p < 0.001). Other effects observed were a change in total cholesterol (-17% in the intervention group vs +2% in the control group, p < 0.001), apolipoprotein B (-15% vs +6%, p < 0.001), and TG (-9% vs + 16%, p = 0.02). Oxidized LDL decreased by 20% vs an increase of 5% in the control group (p < 0.001). Systolic and diastolic arterial blood pressure decreased significantly by 10 mmHg (vs 0% in the control group, p = 0.001) and 7 mmHg (vs 0% in the control group, p = 0.05) respectively. One person in the intervention group, who suffered from Segawa's syndrome, dropped out because of severe muscle ache.
   Conclusions: The combination of active products in this study may be an alternative approach to statins in people who do not need, or cannot or do not want to be treated with chemical statins. Side effects, effects on oxidative stress and on glucose metabolism need to be examined more thoroughly.
C1 [Verhoeven, Veronique; Remmen, Roy; Wens, Johan] Univ Antwerp, Fac Med & Hlth Sci, Acad Ctr Primary & Interdisciplinary Care, B-2020 Antwerp, Belgium.
   [Van der Auwera, Anastasia; Apers, Sandra; Hermans, Nina] Univ Antwerp, Nat Prod & Food Res & Anal NatuRA, Dept Pharmaceut Sci, B-2020 Antwerp, Belgium.
   [Van Gaal, Luc] Univ Antwerp Hosp, Dept Endocrinol Diabetol & Metab, Fac Med, B-2650 Antwerp, Belgium.
   [Stalpaert, Michel] Sonic Healthcare Benelux, Lab Mol & Clin Pathol RIATOL, AML, B-2020 Antwerp, Belgium.
C3 University of Antwerp; University of Antwerp; University of Antwerp
RP Verhoeven, V (corresponding author), Univ Antwerp, Fac Med & Hlth Sci, Acad Ctr Primary & Interdisciplinary Care, B-2020 Antwerp, Belgium.
EM veronique.verhoeven@uantwerpen.be
RI Apers, Sandra/P-6286-2016; Remmen, Roy/H-7302-2016; Wens,
   Johan/K-2705-2013; Hermans, Nina/A-5244-2017; Verhoeven,
   Veronique/B-5915-2017
OI Wens, Johan/0000-0002-0229-9064; Hermans, Nina/0000-0003-3946-7313;
   Verhoeven, Veronique/0000-0002-3708-6501
FU Tilman sa, Z. I. Sud 15, Baillonville, Belgium
FX This study was partly funded by a grant of Tilman sa, Z. I. Sud 15,
   B-5377 Baillonville, Belgium who produces the product under study
   (commercially available as Cholesfytol plus). Tilman had no
   methodological or any other input in design, execution or reporting of
   this study. Tilman had no access to the detailed study protocol, names
   of study participants or raw study data. Before starting the study, it
   was agreed specifically that the study would be published, regardless of
   the results.
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NR 44
TC 42
Z9 45
U1 3
U2 31
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1472-6882
J9 BMC COMPLEM ALTERN M
JI BMC Complement. Altern. Med.
PD MAR 10
PY 2015
VL 15
AR 52
DI 10.1186/s12906-015-0576-9
PG 8
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA CD6KP
UT WOS:000351198300001
PM 25879228
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Sipahioglu, NT
   Ilerigelen, B
   Gungor, ZB
   Ayaz, G
   Ekmekci, H
   Gurel, CB
   Can, G
   Sonmez, H
   Ulutin, T
   Sipahioglu, F
AF Sipahioglu, Nurver Turfaner
   Ilerigelen, Bans
   Gungor, Zeynep B.
   Ayaz, Gulsel
   Ekmekci, Hakan
   Gurel, Cigdem Bayram
   Can, Gunay
   Sonmez, Huseyin
   Ulutin, Turgut
   Sipahioglu, Fikret
TI Relation of Biochemical Parameters with Flow-mediated Dilatation in
   Patients with Metabolic Syndrome
SO CHINESE MEDICAL JOURNAL
LA English
DT Article
DE Endothelial Dysfunction; Metabolic Syndrome; Oxidative Stress; Smoking
ID CARDIOVASCULAR RISK-FACTORS; OXIDATIVE STRESS; ENDOTHELIAL FUNCTION;
   BRACHIAL-ARTERY; NITRIC-OXIDE; SYNTHASE EXPRESSION; NATIONAL-HEALTH;
   PREDICTS; VASODILATION; ASSOCIATION
AB Background: Metabolic syndrome (MetS) is one of the high cardiovascular (CV) situations. Endothelial dysfunction, which is a common finding in patients with MetS, is related with increased CV risk. In patients with MetS, the effect of the maj or CV risk factors, not included in the MetS definition, on endothelial dysfunction is not well known. The aim of this study was to determine the effect of major CV risk factors such as gender, smoking, family history, and biochemical parameters on endothelial dysfunction in patients with MetS.
   Methods: The study was performed between December 2010 andAugust 2014. Atotal of 55 patients (15 females and 40 males) with MetS and 81 healthy controls (37 females and 44 males) with a body mass index < 25 kg/m(2) were enrolled in the study. Endothelial dysfunction was measured by flow-mediated dilatation (FMD), oxidative stress parameters; high-sensitivity C-reactive protein (hs-CRP), oxidized low-density lipoprotein (ox-LDL), endothelial nitric oxide synthase (e-NOS), nitric oxide, and cell adhesion markers; von Willebrand factor, and e-selectin. Platelet aggregation (endothelial adenosine diphosphate), total platelet count, and mean platelet volume were additionally analyzed and demographic parameters were explored. Student's t-test, Mann-Whitney U-test, and Chi-square test were used to analyze the results.
   Results: The fasting blood glucose (z = 3.52, P = 0.001), hs-CRP (z = 3.23, P = 0.004), ox-LDL (z = 2.62, P = 0.013), and e-NOS (z = 2.22, P = 0.026) levels and cardiac risk score (z = 5.23, P < 0.001) were significantly higher in patients with MetS compared with the control group. Smoking was correlated with decreased FMD (chi(2) = 9.26, P = 0.002) in MetS patients but not in the control group.
   Conclusions: Increased ox-LDL, hs-CRP, and e-NOS are likely to be a result of oxidative stress, a condition in which an imbalance occurs between the production and inactivation of reactive nitrogen and oxygen species. In addition, in patients with MetS, smoking is independently related to endothelial dysfunction.
C1 [Sipahioglu, Nurver Turfaner] Istanbul Univ, Cerrahpasa Med Fac, Dept Family Med, TR-34303 Istanbul, Turkey.
   [Ilerigelen, Bans] Istanbul Univ, Cerrahpasa Med Fac, Dept Cardiol, TR-34303 Istanbul, Turkey.
   [Gungor, Zeynep B.; Ekmekci, Hakan; Sonmez, Huseyin] Istanbul Univ, Cerrahpasa Med Fac, Dept Biochem, TR-34303 Istanbul, Turkey.
   [Ayaz, Gulsel; Gurel, Cigdem Bayram; Ulutin, Turgut] Istanbul Univ, Cerrahpasa Med Fac, Dept Med Biol, TR-34303 Istanbul, Turkey.
   [Can, Gunay] Istanbul Univ, Cerrahpasa Med Fac, Dept Publ Hlth, TR-34303 Istanbul, Turkey.
   [Sipahioglu, Fikret] Istanbul Univ, Cerrahpasa Med Fac, Dept Internal Med, TR-34303 Istanbul, Turkey.
C3 Istanbul University; Istanbul University - Cerrahpasa; Istanbul
   University; Istanbul University - Cerrahpasa; Istanbul University -
   Cerrahpasa; Istanbul University; Istanbul University; Istanbul
   University - Cerrahpasa; Istanbul University - Cerrahpasa; Istanbul
   University; Istanbul University; Istanbul University - Cerrahpasa
RP Can, G (corresponding author), Istanbul Univ, Cerrahpasa Med Fac, Dept Publ Hlth, TR-34303 Istanbul, Turkey.
EM nurverdi@gmail.com
RI Ulutin, Turgut/C-9501-2019; Sipahioglu, Nurver/AAA-3978-2020; Sönmez,
   Hüseyin/D-2756-2019; Can, Günay/AAB-1669-2020; GUREL,
   CIGDEM/AAN-7369-2021; Ekmekci, Hakan/D-4969-2019; Gungor,
   Zeynep/D-3779-2019
OI Ekmekci, Hakan/0000-0002-5605-2980; Sonmez, Huseyin
   Avni/0000-0003-2344-0888; Bayram Gurel, Cigdem/0000-0001-9407-7735;
   Gungor, Zeynep/0000-0002-0649-844X; CAN, GUNAY/0000-0001-5815-6700
FU Scientific Research Project Unit, Istanbul University [268573]
FX This work was supported by Scientific Research Project Unit, Istanbul
   University (No: 268573).
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NR 36
TC 4
Z9 4
U1 0
U2 15
PU MEDKNOW PUBLICATIONS & MEDIA PVT LTD
PI MUMBAI
PA B-9, KANARA BUSINESS CENTRE, OFF LINK RD, GHAKTOPAR-E, MUMBAI, 400075,
   INDIA
SN 0366-6999
J9 CHINESE MED J-PEKING
JI Chin. Med. J.
PD JUL 5
PY 2017
VL 130
IS 13
BP 1564
EP 1569
DI 10.4103/0366-6999.208231
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA EY9EE
UT WOS:000404301100009
PM 28639572
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Werba, JP
   Giroli, MG
   Simonelli, N
   Vigo, L
   Gorini, A
   Bonomi, A
   Veglia, F
   Tremoli, E
AF Werba, Jose P.
   Giroli, Monica G.
   Simonelli, Niccolo
   Vigo, Lorenzo
   Gorini, Alessandra
   Bonomi, Alice
   Veglia, Fabrizio
   Tremoli, Elena
TI Uptake and effectiveness of a primary cardiovascular prevention program
   in an underserved multiethnic urban community
SO NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
LA English
DT Article
DE Primary cardiovascular prevention program; Communities; Inclusiveness;
   Multidisciplinary care
ID HEALTH LITERACY; BLOOD-PRESSURE; RISK-FACTORS; DISEASE PREVENTION;
   FOLLOW-UP; PREVALENCE; INDIVIDUALS; POPULATIONS; PERCEPTION; DEPRESSION
AB Background and aims: Cardiometabolic risk is increased among disadvantaged people and ethnic minorities. Paradoxically, their uptake of primary cardiovascular prevention is relatively low. New strategies are needed to tackle this public health problem. Aims of this study were to assess the uptake (as well as its determinants) and effectiveness of a primary cardiovascular prevention program for communities devised to facilitate access of disadvantaged and inclusion of ethnic minorities in addition to providing a state-of-the-art interdisciplinary personalized care.
   Methods and results: Single center, hospital-based, open study. All the residents in an underserved multiethnic urban community aged 40-65 years (n = 1646, 43.6% immigrants) were proactively invited by post mail to participate in a cardiovascular prevention program and different approaches were adopted to promote accessibility and inclusiveness. Program uptake was 23% and individual features independently associated with program uptake were status of immigrant (OR [CI 95%]: 3.6 [2.6-5.1]), higher educational level (3.6 [2.8-4.7]), and female gender (1.6 [1.2-2.1]). Retention was 82% at 6 months and 69% at 12 months. A predefined outcome of global cardiovascular risk improvement at 12 months in subjects with glycaemia >126 mg/dl, LDL-C >115 mg/dl, systolic blood pressure >= 140 mmHg or BMI >28 at baseline was reached in 35%, 33%, 37% and 7% of the patients, respectively. 20% of smokers quitted and significant favorable changes were reported in diet quality, anxiety, depression and physical activity.
   Conclusion: Access inequalities to effective prevention may be counteracted, but increasing global uptake requires further upstream sensitization and awareness actions. (C) 2022 The Author(s). Published by Elsevier B.V. on behalf of The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University.
C1 [Werba, Jose P.; Giroli, Monica G.; Simonelli, Niccolo; Vigo, Lorenzo; Bonomi, Alice; Veglia, Fabrizio; Tremoli, Elena] Ctr Cardiol Monzino, IRCCS, Via Carlo Parea 4, I-20138 Milan, Italy.
   [Simonelli, Niccolo] Azienda Osped Ss Antonio & Biagio & Cesare Arrigo, Struttura Complessa Cardiol, I-15121 Alessandria, Italy.
   [Gorini, Alessandra] Univ Milan, Dept Oncol & Hematooncol, Via Santa Sofia 9-A, I-20122 Milan, Italy.
   [Gorini, Alessandra] Ist Clin Sci Maugeri Milano, IRCCS, I-20138 Milan, Italy.
   [Veglia, Fabrizio; Tremoli, Elena] Maria Cecilia Hosp, Via Corriera 1, I-48033 Cotignola Ravenna, Italy.
C3 IRCCS Centro Cardiologico Monzino; Azienda Ospedaliera SS Antonio Biagio
   Cesare Arrigo; University of Milan; Maria Cecilia Hospital
RP Werba, JP (corresponding author), Ctr Cardiol Monzino, Via Parea 4, I-20138 Milan, Italy.
EM pablo.werba@ccfm.it
RI Bonomi, Alice/AAB-6147-2020; Werba, José/AAC-8973-2019; Gorini,
   Alessandra/C-6689-2011; Giroli, Monica Gianna/D-4323-2019; Veglia,
   Fabrizio/K-1958-2016
OI Gorini, Alessandra/0000-0003-3216-1784; Giroli, Monica
   Gianna/0000-0002-9200-8821; Veglia, Fabrizio/0000-0002-9378-8874;
   Bonomi, Alice/0000-0001-5409-0791
FU Italian Ministry of Health
FX This work was funded by the Italian Ministry of Health, Ricerca Corrente
   to Centro Cardiologico Monzino, IRCCS, years 2014e2019.
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NR 51
TC 1
Z9 1
U1 0
U2 0
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 0939-4753
EI 1590-3729
J9 NUTR METAB CARDIOVAS
JI Nutr. Metab. Carbiovasc. Dis.
PD MAY
PY 2022
VL 32
IS 5
BP 1110
EP 1120
DI 10.1016/j.numecd.2022.01.013
EA APR 2022
PG 11
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism; Nutrition
   & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism;
   Nutrition & Dietetics
GA 3F0TG
UT WOS:000830386000004
PM 35260313
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Zhang, SW
   Lin, JT
AF Zhang, Shuwen
   Lin, Jiangtao
TI Association of circadian syndrome and lung health: A population-based
   cohort study
SO RESPIRATORY MEDICINE
LA English
DT Article
DE Circadian syndrome; Chronic respiratory diseases; Respiratory symptoms;
   Lung function; Metabolic syndrome
ID METABOLIC SYNDROME; ATOPIC-DERMATITIS; ASTHMA; CLOCK; DEPRESSION;
   INFLAMMATION; PREVALENCE; MORTALITY; RECEPTOR; PROTEIN
AB Background: Few studies have explored the association between circadian syndrome (CircS) and lung health. Objective: To assess the relationship between CircS and lung health. Methods: This prospective cohort study enrolled 6252 adults. Multivariable logistic and linear regression models were employed to examine the association between CircS and the prevalence of chronic lung disease, respiratory symptoms, and lung function, as appropriate. Receiver operating characteristic curve analysis was used to compare the predictive power of the number of metabolic syndrome (MetS) and CircS components for lung health. Kaplan-Meier survival and multiple Cox regression analyses were used to assess the relationship between CircS and all-cause mortality. The effects of CircS on health-related quality of life (HQL) and health care use were also evaluated. Results: Participants with CircS were significantly associated with a higher prevalence of asthma, chronic bronchitis, cough, wheeze, phlegm production, and exertional dyspnea. The number of CircS components demonstrated better predictive power for the prevalence of asthma, chronic bronchitis, emphysema, cough, wheeze, phlegm production, and exertional dyspnea than the number of MetS components. Higher numbers of CircS components were significantly associated with decreased forced expiratory volume in the first second (FEV1) and forced vital capacity (FVC), worse HQL, and increased health care use. Longitudinally, participants with CircS exhibited a higher risk of all-cause mortality than those without CircS. Conclusions: Our results support the claim of that CircS is a better predictor of lung health than the MetS in adults in the United States. Elevated CircS levels are associated with poorer lung function, increased health care use, worse HQL, and a higher risk of mortality.
C1 [Zhang, Shuwen] Peking Univ, Grad Sch, China Japan Friendship Sch Clin Med, Beijing 100029, Peoples R China.
   [Zhang, Shuwen; Lin, Jiangtao] China Japan Friendship Hosp, Ctr Resp Med, Dept Pulm & Crit Care Med, Beijing 100029, Peoples R China.
C3 Peking University; China-Japan Friendship Hospital
RP Lin, JT (corresponding author), China Japan Friendship Hosp, Ctr Resp Med, Dept Resp & Crit Care Med, Beijing 100029, Peoples R China.
EM jiangtao_l@263.net
RI Lin, Jiangtao/AAF-3565-2020; Zhang, Shuwen/LPP-3655-2024
FU National Natural Science Foundation of China [8217010602]
FX This work was supported by the National Natural Science Foundation of
   China (8217010602) .
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NR 52
TC 0
Z9 0
U1 2
U2 2
PU W B SAUNDERS CO LTD
PI LONDON
PA 32 JAMESTOWN RD, LONDON NW1 7BY, ENGLAND
SN 0954-6111
EI 1532-3064
J9 RESP MED
JI Respir. Med.
PD APR-MAY
PY 2025
VL 240
AR 108031
DI 10.1016/j.rmed.2025.108031
EA MAR 2025
PG 10
WC Cardiac & Cardiovascular Systems; Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System
GA 0KF1V
UT WOS:001449337200001
PM 40058667
DA 2025-06-11
ER

PT J
AU Lang, F
   Huang, DY
   Vallon, V
AF Lang, Florian
   Huang, Dan Yang
   Vallon, Volker
TI SGK, renal function and hypertension
SO JOURNAL OF NEPHROLOGY
LA English
DT Article
DE Blood pressure; Coagulation; Fibrosis; Inflammation; Obesity
ID INDUCIBLE KINASE SGK1; PROTEIN-KINASE; MICE LACKING; BLOOD-PRESSURE;
   SGK1-KNOCKOUT MOUSE; ENAC ACTIVITY; SERUM; SALT; ALDOSTERONE; RETENTION
AB Serum- and glucocorticoid-inducible kinase 1 (SGK1) is expressed following cell stress and exposure to a variety of hormones including glucocorticoids and mineralocorticoids. It is activated by insulin and growth factors via phosphatidylinositol-3-kinase and the 3-phosphoinositide-dependent kinase PDK1. SGK1 enhances the activity of a variety of ion channels such as ENaC, TRPV5, ROMK, KCNE1/KCNQ1 and ClCKb; carriers such as NHE3, NKCC2, NCC and SGLT1; as well as the Na(+)/K(+)-ATPase. SGK1 contributes to Na(+) retention and K(+) elimination of the kidney as well as mineralocorticoid stimulation of salt appetite. A certain SGK1 gene variant (combined polymorphisms in intron 6 [I6CC] and in exon 8 [E8CC/CT]) is associated with moderately enhanced blood pressure. The SGK1 gene variant has been shown to affect 3%-5% of whites and some 10% of Africans. The gene variant sensitizes the carriers to the hypertensive effects of hyperinsulinemia. Moreover, the SGK1 gene variant is associated with increased body mass index, presumably a result of enhanced SGLT1 activity with accelerated intestinal glucose absorption. Obesity predisposes the carriers of the gene variant to development of type 2 diabetes. Moreover, SGK1 stimulates coagulation. Thus, SGK1 may participate in the pathogenesis of metabolic syndrome or syndrome X, a condition characterized by the coincidence of essential hypertension, procoagulant state, obesity, insulin resistance and hyperinsulinemia.
C1 [Lang, Florian] Univ Tubingen, Dept Physiol, DE-72076 Tubingen, Germany.
   [Huang, Dan Yang] Univ Tubingen, Dept Pharmacol, DE-72076 Tubingen, Germany.
   [Vallon, Volker] Univ Calif San Diego, Dept Med, VA San Diego Healthcare Syst, San Diego, CA 92103 USA.
   [Vallon, Volker] Univ Calif San Diego, Dept Pharmacol, VA San Diego Healthcare Syst, San Diego, CA 92103 USA.
C3 Eberhard Karls University of Tubingen; Eberhard Karls University of
   Tubingen; US Department of Veterans Affairs; Veterans Health
   Administration (VHA); VA San Diego Healthcare System; University of
   California System; University of California San Diego; University of
   California System; University of California San Diego; US Department of
   Veterans Affairs; Veterans Health Administration (VHA); VA San Diego
   Healthcare System
RP Lang, F (corresponding author), Univ Tubingen, Dept Physiol, Gmelinstr 5, DE-72076 Tubingen, Germany.
EM florian.lang@uni-tuebingen.de
OI Vallon, Volker/0000-0002-9211-2063
FU NHLBI NIH HHS [R01 HL094728, HL094728] Funding Source: Medline; NIDDK
   NIH HHS [P30DK079337, R01DK56248, R01 DK056248, P30 DK079337] Funding
   Source: Medline; NIGMS NIH HHS [GM66232, R01 GM066232] Funding Source:
   Medline
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NR 34
TC 25
Z9 30
U1 0
U2 2
PU WICHTIG EDITORE
PI MILAN
PA 72/74 VIA FRIULI, 20135 MILAN, ITALY
SN 1121-8428
J9 J NEPHROL
JI J. Nephrol.
PD NOV-DEC
PY 2010
VL 23
SU 16
SI SI
BP S124
EP S129
PG 6
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 740XT
UT WOS:000288828400017
PM 21170869
DA 2025-06-11
ER

PT J
AU Rinkevich, D
   Belcik, T
   Gupta, NC
   Cannard, E
   Alkayed, NJ
   Kaul, S
AF Rinkevich, Diana
   Belcik, Todd
   Gupta, Nandita C.
   Cannard, Elizabeth
   Alkayed, Nabil J.
   Kaul, Sanjiv
TI Coronary Autoregulation Is Abnormal in Syndrome X: Insights Using
   Myocardial Contrast Echocardiography
SO JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY
LA English
DT Article
DE Syndrome X; Myocardial contrast echocardiography; Coronary
   autoregulation
ID SYNDROME EVALUATION WISE; BLOOD-FLOW RESERVE; CARDIAC SYNDROME-X;
   CHEST-PAIN; ARTERY-DISEASE; ANGINA-PECTORIS; NATIONAL-HEART; WOMEN;
   PERFUSION; ISCHEMIA
AB Background: Syndrome X in women is thought to be caused by coronary microvascular dysfunction, the exact site of which is unknown. The aim of this study was to characterize the microvascular site of dysfunction in these patients using myocardial contrast echocardiography.
   Methods: Women with exertional angina, positive test results on stress imaging, but no coronary artery disease (the study group, n = 18) and age-matched control women also with no coronary artery disease (n = 17) were enrolled. Myocardial contrast echocardiography was performed at rest and during dipyridamole-induced hyperemia. Mean microbubble velocity (beta) and myocardial blood volume (A) were measured, and myocardial blood flow (A . beta) was computed. In addition, plasma concentrations of eicosanoids, female sex hormones, and C-reactive protein were measured.
   Results: Rest beta and myocardial blood flow (A . beta) were higher in the study compared with the control women (1.61 +/- 0.68 vs 0.74 +/- 0.44, P = .0001, and 157 +/- 121 vs 54 +/- 54, P = 0.0001, respectively) despite similar heart rates and systolic blood pressures. After the administration of dipyridamole, whereas the changes in A and A . beta were not significantly different between the two groups, beta reserve (the ratio of stress beta to rest beta) was markedly lower in the study group (1.48 +/- 0.62 vs 2.78 +/- 0.94, P = .0001). Blood hematocrit, eicosanoids, female sex hormones, glucose, and C-reactive protein were not different between the two groups.
   Conclusions: Coronary autoregulation is abnormal in patients with syndrome X (higher resting beta and myocardial blood flow and lower beta reserve), which suggests that the coronary resistance vessels are the site of microvascular abnormality. (J Am Soc Echocardiogr 2013;26:290-6.)
C1 [Rinkevich, Diana; Belcik, Todd; Gupta, Nandita C.; Cannard, Elizabeth; Alkayed, Nabil J.; Kaul, Sanjiv] Oregon Hlth & Sci Univ, Knight Cardiovasc Inst, Portland, OR 97239 USA.
C3 Oregon Health & Science University
RP Kaul, S (corresponding author), Oregon Hlth & Sci Univ, Knight Cardiovasc Inst, 3181 SW Sam Jackson Pk Rd,UHN 62, Portland, OR 97239 USA.
EM kauls@ohsu.edu
FU Bechen Family Foundation; Alpha Phi Foundation (Portland, OR); National
   Institutes of Health (Bethesda, MD) [R01 NS44313, NS070837,
   PO1-HD034430]
FX This study was supported in part by grants to Dr. Rinkevich from the
   Bechen Family Foundation and the Alpha Phi Foundation (Portland, OR) and
   grants R01 NS44313 and NS070837 to Dr. Alkayed and PO1-HD034430 to Dr.
   Kaul from the National Institutes of Health (Bethesda, MD).
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NR 42
TC 29
Z9 36
U1 0
U2 3
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0894-7317
J9 J AM SOC ECHOCARDIOG
JI J. Am. Soc. Echocardiogr.
PD MAR
PY 2013
VL 26
IS 3
BP 290
EP 296
DI 10.1016/j.echo.2012.12.008
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 094US
UT WOS:000315290200012
PM 23313388
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Franckilin, LRD
   Dos Santos, ACPM
   Freitas, FEDA
   Vieira, IG
   Jorge, CED
   Neri, DG
   de Abreu, MVC
   Fonseca, JK
   Loffi, RG
   Foureaux, G
AF de Sousa Franckilin, Laryssa Rosa
   Dos Santos, Anna Clara Paiva Menezes
   Freitas, Flavio Eduardo Dias Araujo
   Vieira, Isabela Garbazza
   de Freitas Jorge, Carlos Eduardo
   Neri, Daniela Godoy
   de Abreu, Maria Vitoria Cota
   Fonseca, Janaina Koenen
   Loffi, Renato Guimaraes
   Foureaux, Giselle
TI Gluten: do only celiac patients benefit from its removal from the diet?
SO FOOD REVIEWS INTERNATIONAL
LA English
DT Review
DE Gluten; celiac disease; wheat allergy; non-celiac gluten sensitivity;
   gluten free diet
ID AUTISM SPECTRUM DISORDERS; BONE-MINERAL DENSITY; CASEIN-FREE DIET;
   LONG-TERM; NATIONAL-HEALTH; METABOLIC SYNDROME; GUT PERMEABILITY;
   DISEASE PATIENTS; DIABETES CONTROL; CONTROLLED TRIAL
AB Gluten is the most common protein in wheat and is related to different pathogeneses. There are three main gluten-related disorders: celiac disease (CD), wheat allergy (WA), and non-celiac gluten sensitivity (NCGS). Clinical manifestations are strictly related in all of them, such as abdominal pain and distention, however the development pathways may differ. The diagnosis criteria are also different, in CD features immunological markers such as IgA, while WA presents IgE markers, and NCGS does not have any specific immunological marker. The consumption of wheat, and consequently gluten-related products, is historical and it has grown over human evolution, which leads us to question what role this component plays in other diseases, and the consequence of a gluten-free diet (GFD). GFD is the treatment with major efficacy in CD and, likewise, is related with improvements in neuropathologies (autism spectrum disorder, anxiety, depression and schizophrenia), obesity, and the gut microbiome. Further investigation is required. GFD studies in people who do not present CD seem to be safe, especially when products containing gluten are not replaced by processed gluten-free products but by minimally processed foods, and also when the food strategy is accompanied by a qualified professional.
C1 [de Sousa Franckilin, Laryssa Rosa; Dos Santos, Anna Clara Paiva Menezes; Vieira, Isabela Garbazza; de Abreu, Maria Vitoria Cota; Foureaux, Giselle] Univ Fed Minas Gerais, Dept Morfol, Belo Horizonte, MG, Brazil.
   [Freitas, Flavio Eduardo Dias Araujo] Univ Fed Ouro Preto, Dept Ciencias Exatas & Biol ICEB, Ouro Preto, Brazil.
   [de Freitas Jorge, Carlos Eduardo; Foureaux, Giselle] Angiogold Med Integrat, Dept Nutr, Belo Horizonte, MG, Brazil.
   [Neri, Daniela Godoy; Fonseca, Janaina Koenen] Clin Med Integrada, Belo Horizonte, MG, Brazil.
   [Loffi, Renato Guimaraes] Treini Biotecnol Ltda, Dept Ciencia Tecnol & Inovacao, Belo Horizonte, MG, Brazil.
C3 Universidade Federal de Minas Gerais; Universidade Federal de Ouro Preto
RP Foureaux, G (corresponding author), Univ Fed Minas Gerais, BR-31270901 Belo Horizonte, MG, Brazil.
EM gifoureaux@yahoo.com.br
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NR 203
TC 0
Z9 0
U1 1
U2 39
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 8755-9129
EI 1525-6103
J9 FOOD REV INT
JI Food Rev. Int.
PY 2023
VL 39
IS 7
BP 4388
EP 4418
DI 10.1080/87559129.2021.2024566
EA JAN 2022
PG 31
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA U5IO8
UT WOS:000750905600001
DA 2025-06-11
ER

PT J
AU Sato, K
   Kawamura, T
   Yamagiwa, S
AF Sato, Kazunari
   Kawamura, Toshihiko
   Yamagiwa, Satoshi
TI The "Senobi" breathing exercise ameliorates depression in obese women
   through up-regulation of sympathetic nerve activity and hormone
   secretion
SO BIOMEDICAL RESEARCH-TOKYO
LA English
DT Article
ID GROWTH-HORMONE; VISCERAL FAT; METABOLIC SYNDROME; ADULTS; HYPOTHESIS;
   DISEASE; LEPTIN; TISSUE; MOOD; MASS
AB Obese individuals have an increased risk of developing depression. This study aimed to determine whether the "Senobi" breathing exercise (SBE), a stretching-breathing exercise that we have established, could relieve depression, especially in obese women. Forty premenopausal women, aged 40 to 49 years, participated in the present study. Twenty were healthy, and the other 20 were obese (body mass index > 25 and body fat > 30%) and in a depressive state (OWD). Sympathetic nerve activity determined by analyzing heart rate variability, and the hormone levels in the urine were investigated before and 30 min after one minute of SBE. The relative proportion of sympathetic nerve activity among healthy women in the daytime was 79.2 +/- 2.3%, whereas that in OWD group was 30.4 +/- 1.9%. After one minute of SBE, significant up-regulation of sympathetic nerve activity and increased concentrations of catecholamines, estradiol, and growth hormone (all P values < 0.001) were observed in OWD group. After 30 days of SBE, the sympathetic nerve activity and hormone levels had recovered in OWD group, and the depressive state, as evaluated by the Hamilton Depression Scale, had ameliorated. The "Senobi" breathing exercise was found to be effective for amelioration of depression in obese women possibly through up-regulation of sympathetic nerve activity and hormone secretion.
C1 [Sato, Kazunari] Aoyama Clin, Div Internal Med, Nishi Ku, Niigata 9502002, Japan.
   [Sato, Kazunari] Meirin Coll, Div Internal Med, Niigata, Japan.
   [Kawamura, Toshihiko] Niigata Univ, Sch Med, Dept Immunol, Niigata, Japan.
   [Yamagiwa, Satoshi] Niigata Univ, Div Gastroenterol & Hepatol, Grad Sch Med & Dent Sci, Niigata, Japan.
C3 Niigata University; Niigata University
RP Sato, K (corresponding author), Aoyama Clin, Div Internal Med, Nishi Ku, 1-2-21 Aoyama, Niigata 9502002, Japan.
EM mansankkk@yahoo.co.jp
FU Japan Society for the Promotion of Science (JSPS)
FX This work was supported in part with a grant from Japan Society for the
   Promotion of Science (JSPS). We thank 40 women participated in this
   study who permitted to publish this information about their cases.
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NR 31
TC 2
Z9 3
U1 0
U2 4
PU BIOMEDICAL RESEARCH PRESS LTD
PI SAPPORO
PA HOKKAIDO UNIV, LAB HISTOLOGY & CYTOLOGY, C/O TOSHIHIKO IWANAGA, KITA
   15-NISHI 7, SAPPORO, 060-8638, JAPAN
SN 0388-6107
J9 BIOMED RES-TOKYO
JI Biomed. Res.
PD APR
PY 2011
VL 32
IS 2
BP 175
EP 180
DI 10.2220/biomedres.32.175
PG 6
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 755TA
UT WOS:000289958400012
PM 21551954
OA Bronze
DA 2025-06-11
ER

PT J
AU Bourebaba, L
   Michalak, I
   Baouche, M
   Kucharczyk, K
   Marycz, K
AF Bourebaba, Lynda
   Michalak, Izabela
   Baouche, Meriem
   Kucharczyk, Katarzyna
   Marycz, Krzysztof
TI Cladophora glomerata methanolic extract promotes chondrogenic
   gene expression and cartilage phenotype differentiation in equine
   adipose-derived mesenchymal stromal stem cells affected by metabolic
   syndrome
SO STEM CELL RESEARCH & THERAPY
LA English
DT Article
DE Cladophora glomerata; EMS; ASCs; Chondrogenesis; Hypertrophy; microRNA
ID CHONDROCYTE DIFFERENTIATION; OXIDATIVE STRESS; AGGRECAN GENE;
   DYSFUNCTION; APOPTOSIS; AUTOPHAGY; EMPHASIS; PATHWAY; BINDING; SOX9
AB Background: Chondrogenesis represents a highly dynamic cellular process that leads to the establishment of various types of cartilage. However, when stress-related injuries occur, a rapid and efficient regeneration of the tissues is necessary to maintain cartilage integrity. Mesenchymal stem cells (MSCs) are known to exhibit high capacity for self-renewal and pluripotency effects, and thus play a pivotal role in the repair and regeneration of damaged cartilage. On the other hand, the influence of certain pathological conditions such as metabolic disorders on MSCs can seriously impair their regenerative properties and thus reduce their therapeutic potential.
   Objectives: In this investigation, we attempted to improve and potentiate the in vitro chondrogenic ability of adipose-derived mesenchymal stromal stem cells (ASCs) isolated from horses suffering from metabolic syndrome.
   Methods: Cultured cells in chondrogenic-inductive medium supplemented with Cladophora glomerata methanolic extract were experimented for expression of the main genes and microRNAs involved in the differentiation process using RT-PCR, for their morphological changes through confocal and scanning electron microscopy and for their physiological homeostasis.
   Results: The different added concentrations of C. glomerata extract to the basic chondrogenic inductive culture medium promoted the proliferation of equine metabolic syndrome ASCs (ASCs(EMS)) and resulted in chondrogenic phenotype differentiation and higher mRNA expression of collagen type II, aggrecan, cartilage oligomeric matrix protein, and Sox9 among others. The results reveal an obvious inhibitory effect of hypertrophy and a strong repression of miR-145-5p, miR-146-3p, and miR-34a and miR-449a largely involved in cartilage degradation. Treated cells additionally exhibited significant reduced apoptosis and oxidative stress, as well as promoted viability and mitochondrial potentiation.
   Conclusion: Chondrogenesis in EqASCs(EMS) was found to be prominent after chondrogenic induction in conditions containing C. glomerata extract, suggesting that the macroalgae could be considered for the enhancement of ASC cultures and their reparative properties.
C1 [Bourebaba, Lynda; Baouche, Meriem; Kucharczyk, Katarzyna; Marycz, Krzysztof] Wroclaw Univ Environm & Life Sci, Dept Expt Biol, Fac Biol & Anim Sci, Norwida 27B, PL-50375 Wroclaw, Poland.
   [Bourebaba, Lynda; Baouche, Meriem; Marycz, Krzysztof] Int Inst Translat Med, Jesionowa 11, PL-55114 Wisznia Mala, Malin, Poland.
   [Michalak, Izabela] Wroclaw Univ Sci & Technol, Fac Chem, Dept Adv Mat Technol, Smoluchowskiego 25, PL-50372 Wroclaw, Poland.
   [Marycz, Krzysztof] Cardinal Stefan Wyszynski Univ UKSW, Inst Med Sci, Coll Med, Woycickiego 1-3, PL-01938 Warsaw, Poland.
C3 Wroclaw University of Environmental & Life Sciences; Wroclaw University
   of Science & Technology; Cardinal Stefan Wyszynski University in Warsaw
RP Marycz, K (corresponding author), Wroclaw Univ Environm & Life Sci, Dept Expt Biol, Fac Biol & Anim Sci, Norwida 27B, PL-50375 Wroclaw, Poland.; Marycz, K (corresponding author), Int Inst Translat Med, Jesionowa 11, PL-55114 Wisznia Mala, Malin, Poland.
EM krzysztof.marycz@upwr.edu.pl
RI Bourebaba, Lynda/AAX-7613-2020; Baouche, Meriem/GQP-6178-2022; Michalak,
   Izabela/P-3770-2015
OI Baouche, Meriem/0000-0002-7344-1769; Michalak,
   Izabela/0000-0001-8084-9642; Lynda, Bourebaba/0000-0003-0660-8706
FU National Science Centre in Poland [2015/18/E/NZ9/00607]
FX This work was financed in the framework of grant entitled "The effect of
   bioactive algae enriched by biosorption in the certain minerals such as
   Cr(III), Mg(II) and Mn(II) on the status of glucose in the course of
   metabolic syndrome horses. Evaluation in vitro and in vivo" (No
   2015/18/E/NZ9/00607) attributed by The National Science Centre in
   Poland.
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NR 56
TC 9
Z9 10
U1 0
U2 5
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1757-6512
J9 STEM CELL RES THER
JI Stem Cell Res. Ther.
PD DEC 17
PY 2019
VL 10
IS 1
AR 392
DI 10.1186/s13287-019-1499-z
PG 20
WC Cell & Tissue Engineering; Cell Biology; Medicine, Research &
   Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Research & Experimental Medicine
GA KC6OO
UT WOS:000507294800001
PM 31847882
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Moilanen, P
   Liukkonen, T
   Jokelainen, J
   Keinänen-Kiukaanniemi, S
   Puukka, K
   Timonen, M
   Auvinen, J
   Eskola, P
AF Moilanen, Pauli
   Liukkonen, Timo
   Jokelainen, Jari
   Keinanen-Kiukaanniemi, Sirkka
   Puukka, Katri
   Timonen, Markku
   Auvinen, Juha
   Eskola, Pasi
TI Cross-sectional analysis of depressive symptom profiles and serum
   C-reactive protein levels: data from the Northern Finland 1966 birth
   cohort
SO NORDIC JOURNAL OF PSYCHIATRY
LA English
DT Article
DE Depression; CRP; atypical; non-atypical; BDI-II; birth cohort
ID INFLAMMATORY MARKERS; OLDER-ADULTS; METABOLIC SYNDROME; NATIONAL-HEALTH;
   ASSOCIATION; METAANALYSIS; INTERLEUKIN-6; IL-6; DISORDER; RISK
AB PurposeIndividuals with depression exhibit significantly higher levels of systemic inflammation than those without depression, particularly among those with atypical depression. However, this association has been less convincing at the population level among individuals without a formal depression diagnosis but with suggestive symptoms. Our aim was to clarify this association.Materials and methodsIn a large birth cohort sample of the Finnish general population, we examined the cross-sectional association between high-sensitivity C-reactive protein (hsCRP) levels in venous blood samples and atypical/non-atypical depressive symptoms using the Beck Depression Inventory-II to screen 5443 middle-aged participants.ResultsAs expected, depressive symptoms associated to elevated hsCRP-levels compared to non-depressed. Participants with the atypical subtype of depressive symptoms (n = 84) had an odds ratio (OR) of 2.59 (95% CI 1.40-4.81) for elevated hsCRP levels compared to the non-depressed group. Similarly, our findings indicate that participants with non-atypical symptoms (n = 440) also showed an OR of 1.42 (95% CI 1.05-1.92) when compared to the non-depressed group (n = 4919).ConclusionsThese results provide additional support for previous research linking depression and inflammation and add to the field with a unique and sizeable study population. Furthermore, the current results support the notion that different types of depressive symptoms may be associated with inflammatory markers in slightly different ways.
C1 [Moilanen, Pauli; Liukkonen, Timo; Jokelainen, Jari; Keinanen-Kiukaanniemi, Sirkka; Timonen, Markku; Auvinen, Juha; Eskola, Pasi] Univ Oulu, Res Unit Populat Hlth, Oulu, Finland.
   [Liukkonen, Timo] Savonlinna Cent Hosp, Dept Psychiat, Savonlinna, Finland.
   [Jokelainen, Jari; Keinanen-Kiukaanniemi, Sirkka; Timonen, Markku] Oulu Univ Hosp, Unit Primary Care, Oulu, Finland.
   [Keinanen-Kiukaanniemi, Sirkka; Timonen, Markku; Auvinen, Juha; Eskola, Pasi] Wellbeing Serv Cty North Ostrobothn Pohde, Oulu, Finland.
   [Puukka, Katri] Oulu Univ Hosp, Med Res Ctr Oulu, NordLab Oulu, Oulu, Finland.
   [Puukka, Katri] Univ Oulu, Dept Clin Chem, Oulu, Finland.
   [Auvinen, Juha] Oulu Univ Hosp, Med Res Ctr Oulu, Oulu, Finland.
   [Auvinen, Juha] Univ Oulu, Oulu, Finland.
   [Eskola, Pasi] Univ Oulu, Fac Med, Res Unit Populat Hlth Poph, POB 8000, Oulu 90014, Finland.
C3 University of Oulu; University of Oulu; University of Oulu; University
   of Oulu; University of Oulu; University of Oulu; University of Oulu
RP Eskola, P (corresponding author), Univ Oulu, Fac Med, Res Unit Populat Hlth Poph, POB 8000, Oulu 90014, Finland.
EM pasi.eskola@oulu.fi
FU We express our sincerest gratitude to the field study team and study
   nurses who carried out all of the examinations and data collection. We
   would also like to thank Professor Paula Rantakallio, who launched the
   NFBC1966.
FX We express our sincerest gratitude to the field study team and study
   nurses who carried out all of the examinations and data collection. We
   would also like to thank Professor Paula Rantakallio, who launched the
   NFBC1966.
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NR 58
TC 1
Z9 2
U1 0
U2 1
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0803-9488
EI 1502-4725
J9 NORD J PSYCHIAT
JI Nord. J. Psychiatr.
PD FEB 1
PY 2024
VL 78
IS 2
BP 95
EP 102
DI 10.1080/08039488.2023.2274341
EA OCT 2023
PG 8
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA GH1O7
UT WOS:001090951000001
PM 37905346
DA 2025-06-11
ER

PT J
AU Lin, YH
   Chang, HT
   Wang, YF
   Fuh, JL
   Wang, SJ
   Chen, HS
   Li, SR
   Lin, MH
   Chen, TJ
   Hwang, SJ
AF Lin, Yi-Hsuan
   Chang, Hsiao-Ting
   Wang, Yen-Feng
   Fuh, Jong-Ling
   Wang, Shuu-Jiun
   Chen, Harn-Shen
   Li, Sih-Rong
   Lin, Ming-Hwai
   Chen, Tzeng-Ji
   Hwang, Shinn-Jang
TI The association of the comorbidity status of metabolic syndrome and
   cognitive dysfunction with health-related quality of life
SO QUALITY OF LIFE RESEARCH
LA English
DT Article
DE Metabolic syndrome; Cognitive dysfunction; Health-related quality of
   life; SF-36 Health Survey; Taiwan
ID DISEASE; IMPACT; RISK; IMPAIRMENT; INDIVIDUALS; DEPRESSION; MANAGEMENT
AB Purpose Both metabolic syndrome (MetS) and cognitive dysfunction impair health-related quality of life (HRQOL). This study aims to determine whether individuals experiencing both MetS and cognitive dysfunction have lower HRQOL. Methods This cross-sectional study enrolled 567 participants who attended outpatient clinics at a medical center in northern Taiwan. MetS was diagnosed according to the modified criteria for the Asian population. Cognitive function was categorized as normal, mild cognitive dysfunction, and advanced cognitive dysfunction according to the score of the Montreal Cognitive Assessment, Taiwanese version. HRQOL was assessed using the SF-36v2 (R) Health Survey (SF-36v2). The associations of the comorbidity status of MetS and cognitive dysfunction with HRQOL were analyzed using linear regression models, adjusting for age, sex, marital status, education level, income groups, and activities of daily living. Results Out of 567 participants, 33 (5.8%) had MetS with mild cognitive dysfunction, and 34 (6.0%) had MetS with advanced cognitive dysfunction. Participants with both MetS and advanced cognitive dysfunction exhibited the lowest scores in the physical component summary and almost all scales of HRQOL. MetS exacerbated the inverse association between mild cognitive dysfunction and the mental component summary. For those with MetS, the scores on scales of role physical, bodily pain, vitality, and social functioning worsened as cognitive function deteriorated (all Ptrend<0.05). Conclusion As the severity of comorbidity between MetS and cognitive dysfunction varies, patients exhibited poorer performance in different aspects of HRQOL. Future research is needed to find solutions to improve HRQOL for patients with both MetS and cognitive dysfunction.
C1 [Lin, Yi-Hsuan] Taipei Vet Gen Hosp, Dept Med Educ, Taipei, Taiwan.
   [Lin, Yi-Hsuan; Chang, Hsiao-Ting; Wang, Yen-Feng; Fuh, Jong-Ling; Wang, Shuu-Jiun; Chen, Harn-Shen; Lin, Ming-Hwai; Chen, Tzeng-Ji; Hwang, Shinn-Jang] Natl Yang Ming Chiao Tung Univ, Coll Med, Sch Med, Taipei, Taiwan.
   [Lin, Yi-Hsuan; Chang, Hsiao-Ting; Li, Sih-Rong; Lin, Ming-Hwai; Chen, Tzeng-Ji; Hwang, Shinn-Jang] Taipei Vet Gen Hosp, Dept Family Med, 201 Sec 2,Shipai Rd, Taipei 11217, Taiwan.
   [Wang, Yen-Feng; Fuh, Jong-Ling; Wang, Shuu-Jiun] Taipei Vet Gen Hosp, Neurol Inst, Dept Neurol, Taipei, Taiwan.
   [Chen, Harn-Shen] Taipei Vet Gen Hosp, Dept Med, Div Endocrinol & Metab, Taipei, Taiwan.
   [Chen, Tzeng-Ji] Taipei Vet Gen Hosp, Dept Family Med, Hsinchu Branch, Hsinchu Cty, Taiwan.
   [Chen, Tzeng-Ji] Natl Chung Hsing Univ, Dept Postbaccalaureate Med, Taichung, Taiwan.
   [Hwang, Shinn-Jang] En Chu Kong Hosp, Dept Family Med, New Taipei City, Taiwan.
C3 Taipei Veterans General Hospital; National Yang Ming Chiao Tung
   University; Taipei Veterans General Hospital; Taipei Veterans General
   Hospital; Taipei Veterans General Hospital; Taipei Veterans General
   Hospital; National Chung Hsing University; En Chu Kong Hospital
RP Chang, HT (corresponding author), Natl Yang Ming Chiao Tung Univ, Coll Med, Sch Med, Taipei, Taiwan.; Chang, HT (corresponding author), Taipei Vet Gen Hosp, Dept Family Med, 201 Sec 2,Shipai Rd, Taipei 11217, Taiwan.
EM htchang.tw@gmail.com
RI Fuh, Jong-Ling/AFQ-4531-2022; Chen, TJ/AAH-8430-2021
FU Taipei Veterans General Hospital [V109E-005-4, V110E-005-4, V111E-006-4,
   V112E-004-4]
FX This work was supported by grants from Taipei Veterans General Hospital.
   [Grant number: V109E-005-4, V110E-005-4, V111E-006-4, V112E-004-4]
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NR 50
TC 0
Z9 0
U1 0
U2 2
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0962-9343
EI 1573-2649
J9 QUAL LIFE RES
JI Qual. Life Res.
PD DEC
PY 2024
VL 33
IS 12
BP 3421
EP 3433
DI 10.1007/s11136-024-03784-z
EA SEP 2024
PG 13
WC Health Care Sciences & Services; Health Policy & Services; Public,
   Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services; Public, Environmental & Occupational
   Health
GA N4J3J
UT WOS:001313285000005
PM 39269582
DA 2025-06-11
ER

PT J
AU Liu, H
   Lu, HY
AF Liu, Hong
   Lu, Hong-Yun
TI Nonalcoholic fatty liver disease and cardiovascular disease
SO WORLD JOURNAL OF GASTROENTEROLOGY
LA English
DT Article
DE Nonalcoholic fatty liver disease; Cardiovascular disease; Metabolic
   syndrome; Risk assessment
ID INDEPENDENT RISK-FACTOR; BODY-MASS INDEX; ENDOTHELIAL FUNCTION; ARTERIAL
   STIFFNESS; METABOLIC SYNDROME; MORBID-OBESITY; VITAMIN-E; ASSOCIATION;
   ATHEROSCLEROSIS; STEATOHEPATITIS
AB Nonalcoholic fatty liver disease (NAFLD) and cardiovascular disease (CVD) are two diseases that are common in the general population. To date, many studies have been conducted and demonstrate a direct link between NAFLD and CVD, but the exact mechanisms for this complex relationship are not well established. A systematic search of the PubMed database revealed that several common mechanisms are involved in many of the local and systemic manifestations of NAFLD and lead to an increased cardiovascular risk. The possible mechanisms linking NAFLD and CVD include inflammation, oxidative stress, insulin resistance, ectopic adipose tissue distribution, dyslipidemia, endothelial dysfunction, and adiponectin, among others. The clinical implication is that patients with NAFLD are at an increased risk of CVD and should undergo periodic cardiovascular risk assessment. (C) 2014 Baishideng Publishing Group Inc. All rights reserved.
C1 [Liu, Hong; Lu, Hong-Yun] Sun Yat Sen Univ, Affiliated Hosp 5, Dept Endocrinol & Metab, Zhuhai 519000, Guangdong, Peoples R China.
C3 Sun Yat Sen University
RP Lu, HY (corresponding author), Sun Yat Sen Univ, Affiliated Hosp 5, Dept Endocrinol & Metab, Zhuhai 519000, Guangdong, Peoples R China.
EM luhongyun2013@163.com
RI LU, HONGYUN/AAG-1904-2020
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NR 77
TC 79
Z9 88
U1 0
U2 10
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 8226 REGENCY DR, PLEASANTON, CA 94588 USA
SN 1007-9327
EI 2219-2840
J9 WORLD J GASTROENTERO
JI World J. Gastroenterol.
PD JUL 14
PY 2014
VL 20
IS 26
BP 8407
EP 8415
DI 10.3748/wjg.v20.i26.8407
PG 9
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA AL8LF
UT WOS:000339389500007
PM 25024598
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Wu, Y
   Ma, YC
AF Wu, Yue
   Ma, Yanchun
TI CCL2-CCR2 signaling axis in obesity and metabolic diseases
SO JOURNAL OF CELLULAR PHYSIOLOGY
LA English
DT Review
DE adipose tissue; CCL2; CCR2; inflammation; metabolic syndrome
ID MONOCYTE CHEMOATTRACTANT PROTEIN-1; ENDOPLASMIC-RETICULUM STRESS;
   LOW-DENSITY-LIPOPROTEIN; ADIPOSE-TISSUE HYPOXIA; MACROPHAGE CROSS-TALK;
   INSULIN-RESISTANCE; TRANSGENIC MICE; PHARMACOLOGICAL CHARACTERIZATION;
   REDUCES ATHEROSCLEROSIS; CARDIAC OVEREXPRESSION
AB Obesity and metabolic diseases, such as insulin resistance, type 2 diabetes, nonalcoholic fatty liver disease, and cardiovascular ailments, represent formidable global health challenges, bearing considerable implications for both morbidity and mortality rates. It has become increasingly evident that chronic, low-grade inflammation plays a pivotal role in the genesis and advancement of these conditions. The involvement of C-C chemokine ligand 2 (CCL2) and its corresponding receptor, C-C chemokine receptor 2 (CCR2), has been extensively documented in numerous inflammatory maladies. Recent evidence indicates that the CCL2/CCR2 pathway extends beyond immune cell recruitment and inflammation, exerting a notable influence on the genesis and progression of metabolic syndrome. The present review seeks to furnish a comprehensive exposition of the CCL2-CCR2 signaling axis within the context of obesity and metabolic disorders, elucidating its molecular mechanisms, functional roles, and therapeutic implications.
C1 [Wu, Yue; Ma, Yanchun] Shandong Normal Univ, Collaborat Innovat Ctr Cell Biol Univ Shandong, Shandong Prov Key Lab Anim Resistance Biol, Ctr Cell Struct & Funct,Coll Life Sci, Jinan, Peoples R China.
   [Wu, Yue] Shandong Normal Univ, Collaborat Innovat Ctr Cell Biol Univ Shandong, Shandong Prov Key Lab Anim Resistance Biol, Ctr Cell Struct & Funct,Coll Life Sci, Jinan 250014, Peoples R China.
C3 Shandong Normal University; Shandong Normal University
RP Wu, Y (corresponding author), Shandong Normal Univ, Collaborat Innovat Ctr Cell Biol Univ Shandong, Shandong Prov Key Lab Anim Resistance Biol, Ctr Cell Struct & Funct,Coll Life Sci, Jinan 250014, Peoples R China.
EM 620034@sdnu.edu.cn
FU National Natural Science Foundation of China; Natural Science Foundation
   of Shandong Province [ZR2021QC069];  [32100614]
FX This work was supported by the National Natural Science Foundation of
   China (32100614) and Natural Science Foundation of Shandong Province
   (ZR2021QC069).
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NR 144
TC 12
Z9 12
U1 7
U2 29
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0021-9541
EI 1097-4652
J9 J CELL PHYSIOL
JI J. Cell. Physiol.
PD APR
PY 2024
VL 239
IS 4
DI 10.1002/jcp.31192
EA JAN 2024
PG 16
WC Cell Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Physiology
GA NK0F2
UT WOS:001150725400001
PM 38284280
DA 2025-06-11
ER

PT J
AU Plotogea, O
   Ilie, M
   Sandru, V
   Chiotoroiu, A
   Bratu, O
   Diaconu, C
AF Plotogea, Oana
   Ilie, Madalina
   Sandru, Vasile
   Chiotoroiu, Alexandru
   Bratu, Ovidiu
   Diaconu, Camelia
TI Cardiovascular and Metabolic Consequences of Liver Transplantation: A
   Review
SO MEDICINA-LITHUANIA
LA English
DT Review
DE liver transplantation; cardiovascular complications; metabolic
   consequences; hypertension; dyslipidemia
ID DOBUTAMINE STRESS ECHOCARDIOGRAPHY; CORONARY-ARTERY-DISEASE; AMERICAN
   ASSOCIATION; PRACTICE GUIDELINE; DIABETES-MELLITUS; BLOOD-PRESSURE;
   RISK-FACTORS; COMPLICATIONS; MORTALITY; MANAGEMENT
AB Liver transplantation (LT) is considered the curative treatment option for selected patients who suffer from end-stage or acute liver disease or hepatic malignancy (primary). After LT, patients should be carefully monitored for complications that may appear, partially due to immunosuppressive therapy, but not entirely. Cardiovascular diseases are frequently encountered in patients with LT, being responsible for high morbidity and mortality. Patients with underlying cardiovascular and metabolic pathologies are prone to complications after the transplant, but these complications can also appear de novo, mostly associated with immunosuppressants. Metabolic syndrome, defined by obesity, hypertension, dyslipidemia, and hyperglycemia, is diagnosed among LT recipients and is aggravated after LT, influencing the long-term survival. In this review, our purpose was to summarize the current knowledge regarding cardiovascular (CV) diseases and the metabolic syndrome associated with LT and to assess their impact on short and long-term morbidity and mortality.
C1 [Plotogea, Oana; Ilie, Madalina; Bratu, Ovidiu; Diaconu, Camelia] Univ Med & Pharm Carol Davila, Fac Med, Bucharest 050474, Romania.
   [Plotogea, Oana; Ilie, Madalina; Sandru, Vasile] Clin Emergency Hosp Bucharest, Gastroenterol Clin, Bucharest 014461, Romania.
   [Chiotoroiu, Alexandru] Clin Emergency Hosp Bucharest, Surg Clin, Bucharest 014461, Romania.
   [Bratu, Ovidiu] Emergency Univ, Urol Clin, Cent Mil Hosp, Bucharest 010242, Romania.
   [Diaconu, Camelia] Clin Emergency Hosp Bucharest, Internal Med Clin, Bucharest 014461, Romania.
C3 Carol Davila University of Medicine & Pharmacy
RP Diaconu, C (corresponding author), Univ Med & Pharm Carol Davila, Fac Med, Bucharest 050474, Romania.; Diaconu, C (corresponding author), Clin Emergency Hosp Bucharest, Internal Med Clin, Bucharest 014461, Romania.
EM drcameliadiaconu@gmail.com
RI Plotogea, Oana/ACS-1854-2022; Bratu, Ovidiu/L-3040-2019; Diaconu,
   Camelia/A-2144-2019; Sandru, Vasile/C-4861-2019
OI Plotogea, Oana-Mihaela/0000-0001-5730-9381; bratu,
   ovidiu/0000-0002-6971-9748; Sandru, Vasile/0000-0001-6206-6126
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NR 61
TC 6
Z9 6
U1 0
U2 2
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1010-660X
EI 1648-9144
J9 MEDICINA-LITHUANIA
JI Med. Lith.
PD AUG
PY 2019
VL 55
IS 8
AR 489
DI 10.3390/medicina55080489
PG 10
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA IZ0GQ
UT WOS:000486769900088
PM 31443295
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Vatashchuk, MV
   Bayliak, MM
   Hurza, VV
   Storey, KB
   Lushchak, V
AF Vatashchuk, Myroslava V.
   Bayliak, Maria M.
   Hurza, Viktoria V.
   Storey, Kenneth B.
   Lushchak, Volodymyr, I
TI Metabolic Syndrome: Lessons from Rodent and Drosophila Models
SO BIOMED RESEARCH INTERNATIONAL
LA English
DT Review
ID HIGH-FAT-DIET; SELECTIVE LEPTIN RESISTANCE; INSULIN-RESISTANCE;
   OXIDATIVE STRESS; LIPID-METABOLISM; INDUCED OBESITY; ANIMAL-MODELS;
   MOUSE MODEL; RAT MODELS; RECEPTOR
AB Overweight and obesity are health conditions tightly related to a number of metabolic complications collectively called "metabolic syndrome" (MetS). Clinical diagnosis of MetS includes the presence of the increased waist circumference or so-called abdominal obesity, reduced high density lipoprotein level, elevated blood pressure, and increased blood glucose and triacylglyceride levels. Different approaches, including diet-induced and genetically induced animal models, have been developed to study MetS pathogenesis and underlying mechanisms. Studies of metabolic disturbances in the fruit fly Drosophila and mammalian models along with humans have demonstrated that fruit flies and small mammalian models like rats and mice have many similarities with humans in basic metabolic functions and share many molecular mechanisms which regulate these metabolic processes. In this paper, we describe diet-induced, chemically and genetically induced animal models of the MetS. The advantages and limitations of rodent and Drosophila models of MetS and obesity are also analyzed.
C1 [Vatashchuk, Myroslava V.; Bayliak, Maria M.; Hurza, Viktoria V.; Lushchak, Volodymyr, I] Vasyl Stefanyk Precarpathian Natl Univ, Dept Biochem & Biotechnol, 57 Shevchenko Str, UA-76018 Ivano Frankivsk, Ukraine.
   [Storey, Kenneth B.] Carleton Univ, Inst Biochem, 1125 Colonel By Dr, Ottawa, ON K1S 5B6, Canada.
   [Lushchak, Volodymyr, I] Res & Dev Univ, Shota Rustaveli Str, UA-76018 Ivano Frankivsk, Ukraine.
C3 Ministry of Education & Science of Ukraine; Vasyl Stefanyk Precarpathian
   National University; Carleton University
RP Bayliak, MM; Lushchak, V (corresponding author), Vasyl Stefanyk Precarpathian Natl Univ, Dept Biochem & Biotechnol, 57 Shevchenko Str, UA-76018 Ivano Frankivsk, Ukraine.; Lushchak, V (corresponding author), Res & Dev Univ, Shota Rustaveli Str, UA-76018 Ivano Frankivsk, Ukraine.
EM bayliak@ukr.net
RI Vatashchuk, Myroslava/JVZ-4384-2024; Storey, Kenneth/G-9883-2011;
   Lushchak, Volodymyr/AAV-4256-2021; Bayliak, Maria/P-8950-2015
OI Vatashchuk, Myroslava/0000-0001-5732-2586; Lushchak,
   Volodymyr/0000-0001-5602-3330; Hurza, Viktoriia/0000-0001-9246-2656;
   Bayliak, Maria/0000-0001-6268-8910
FU Ministry of Education and Science of Ukraine [0122U000894]; National
   Research Foundation of Ukraine [2020.02/0118]
FX This work was partially supported by a grant from the Ministry of
   Education and Science of Ukraine (#0122U000894) to VIL and a grant from
   the National Research Foundation of Ukraine (#2020.02/0118) to MMB.
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NR 131
TC 12
Z9 13
U1 1
U2 12
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2314-6133
EI 2314-6141
J9 BIOMED RES INT
JI Biomed Res. Int.
PD JUN 22
PY 2022
VL 2022
AR 5850507
DI 10.1155/2022/5850507
PG 13
WC Biotechnology & Applied Microbiology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Research & Experimental Medicine
GA 5N7EG
UT WOS:000871950300001
PM 35782067
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Gasmi, A
   Mujawdiya, PK
   Noor, S
   Lysiuk, R
   Darmohray, R
   Piscopo, S
   Lenchyk, L
   Antonyak, H
   Dehtiarova, K
   Shanaida, M
   Polishchuk, A
   Shanaida, V
   Peana, M
   Bjorklund, G
AF Gasmi, Amin
   Mujawdiya, Pavan Kumar
   Noor, Sadaf
   Lysiuk, Roman
   Darmohray, Roman
   Piscopo, Salva
   Lenchyk, Larysa
   Antonyak, Halyna
   Dehtiarova, Kateryna
   Shanaida, Mariia
   Polishchuk, Alexandr
   Shanaida, Volodymyr
   Peana, Massimiliano
   Bjorklund, Geir
TI Polyphenols in Metabolic Diseases
SO MOLECULES
LA English
DT Review
DE phenolic compounds; natural sources; metabolic syndrome; bioprotective
   property; therapeutic effect
ID INDUCED INSULIN-RESISTANCE; SALVIANOLIC-ACID-B; OXIDATIVE STRESS;
   DIETARY POLYPHENOLS; IN-VITRO; RED WINE; MYOCARDIAL-INFARCTION;
   ANTIOXIDANT ACTIVITY; PHENOLIC-COMPOUNDS; GRAPE POLYPHENOLS
AB Polyphenols (PPs) are a large group of phytochemicals containing phenolic rings with two or more hydroxyl groups. They possess powerful antioxidant properties, multiple therapeutic effects, and possible health benefits in vivo and in vitro, as well as reported clinical studies. Considering their free-radical scavenging and anti-inflammatory properties, these substances can be used to treat different kinds of conditions associated with metabolic disorders. Many symptoms of metabolic syndrome (MtS), including obesity, dyslipidemia, atherosclerosis, elevated blood sugar, accelerating aging, liver intoxication, hypertension, as well as cancer and neurodegenerative disorders, are substantially relieved by dietary PPs. The present study explores the bioprotective properties and associated underlying mechanisms of PPs. A detailed understanding of these natural compounds will open up new opportunities for producing unique natural PP-rich dietary and medicinal plans, ultimately affirming their health benefits.
C1 [Gasmi, Amin; Piscopo, Salva] Soc Francophone Nutritherapie & Nutrigenet Appl, F-69100 Villeurbanne, France.
   [Gasmi, Amin] Univ Claude Bernard, Lab Interuniv Biol Motricite, F-69100 Villeurbanne, France.
   [Mujawdiya, Pavan Kumar] Birla Inst Technol & Sci Pilani, Hyderabad 500078, India.
   [Noor, Sadaf] Bahauddin Zakariya Univ, Inst Mol Biol & Biotechnol, Multan 60800, Pakistan.
   [Lysiuk, Roman; Darmohray, Roman] Danylo Halytsky Lviv Natl Med Univ, Dept Pharmacognosy & Bot, UA-79010 Lvov, Ukraine.
   [Lysiuk, Roman; Darmohray, Roman] Danylo Halytsky Lviv Natl Med Univ, CONEM Ukraine Life Sci Res Grp, UA-79010 Lvov, Ukraine.
   [Lenchyk, Larysa; Dehtiarova, Kateryna] Natl Univ Pharm, Inst Adv Training Pharm Specialist, UA-61001 Kharkiv, Ukraine.
   [Lenchyk, Larysa; Dehtiarova, Kateryna] Natl Univ Pharm, CONEM Ukraine Pharmacognosy & Nat Prod Chem Res G, UA-61002 Kharkiv, Ukraine.
   [Antonyak, Halyna; Polishchuk, Alexandr] Ivan Franko Natl Univ Lviv, Dept Ecol, UA-79005 Lvov, Ukraine.
   [Shanaida, Mariia] I Horbachevsky Ternopil Natl Med Univ, Dept Pharmacognosy & Med Bot, UA-46001 Ternopol, Ukraine.
   [Shanaida, Volodymyr] Ternopil Ivan Puluj Natl Tech Univ, Design Machine Tools Instruments & Machines Dept, UA-46001 Ternopol, Ukraine.
   [Peana, Massimiliano] Univ Sassari, Dept Chem Phys Math & Nat Sci, Via Vienna 2, I-07100 Sassari, Italy.
   [Bjorklund, Geir] Council Nutr & Environm Med CONEM, N-8610 Mo I Rana, Norway.
C3 Universite Claude Bernard Lyon 1; Birla Institute of Technology &
   Science Pilani (BITS Pilani); Bahauddin Zakariya University; Danylo
   Halytsky Lviv National Medical University; Danylo Halytsky Lviv National
   Medical University; National University of Pharmacy; National University
   of Pharmacy; Ministry of Education & Science of Ukraine; Ivan Franko
   National University Lviv; I. Horbachevsky Ternopil State Medical
   University; Ministry of Education & Science of Ukraine; Ternopil Ivan
   Puluj National Technical University; University of Sassari
RP Bjorklund, G (corresponding author), Council Nutr & Environm Med CONEM, N-8610 Mo I Rana, Norway.
EM bjorklund@conem.org
RI Mujawdiya, Pavan/HJG-7443-2022; Lysiuk, Roman/O-1030-2019; Noor,
   Sadaf/KIA-8696-2024; Shanaida, Volodymyr/AAE-2318-2019; Gasmi,
   Amin/AAL-3595-2020; Lenchyk, Larysa/JCO-4374-2023; Polishchuk,
   Olexandr/AAV-3186-2021; Shanaida, Mariia/AAD-3256-2020; Antonyak,
   Halyna/I-6308-2015; Bjorklund, Geir/B-7319-2014; Peana, Massimiliano
   Francesco/B-6854-2014
OI Lysiuk, Roman/0000-0003-0961-2970; Mujawdiya, Pavan/0000-0003-2437-1263;
   Shanaida, Mariia/0000-0003-1070-6739; Antonyak,
   Halyna/0000-0002-1640-737X; Bjorklund, Geir/0000-0003-2632-3935; Noor,
   Sadaf/0000-0002-4153-7547; Gasmi, Amin/0000-0003-2165-8373; Peana,
   Massimiliano Francesco/0000-0002-3306-0419
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NR 267
TC 88
Z9 88
U1 8
U2 48
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1420-3049
J9 MOLECULES
JI Molecules
PD OCT
PY 2022
VL 27
IS 19
AR 6280
DI 10.3390/molecules27196280
PG 34
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 5G6HT
UT WOS:000867098600001
PM 36234817
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Kozlowska, D
   Mysliwiec, H
   Flisiak, I
AF Kozlowska, Dorota
   Mysliwiec, Hanna
   Flisiak, Iwona
TI Inflammation and lipid metabolism as a strong background connecting
   psoriasis and liver diseases
SO PRZEGLAD DERMATOLOGICZNY
LA English
DT Review
DE metabolic syndrome; psoriasis; inflammation; lipids; non-alcoholic;
   fatty liver disease
ID FATTY LIVER; BILIARY-CIRRHOSIS; HEPATITIS; RISK; CERAMIDES; ARTHRITIS;
   PROFILE; NAFLD; IL-6
AB Psoriasis is not an isolated pathology of the skin and joints, but is also characterized by multiple extracutaneous systemic manifestations. Beside the co-occurrence of obesity, arterial hypertension, dyslipidemia, and type 2 diabetes mellitus, there is a strong correlation with many liver disturbances. The most common liver comorbid disease coexisting with psoriasis is non-alcoholic fatty liver disease, which is a hepatic manifestation of metabolic syndrome. Both diseases share the same molecular mechanisms: chronic systemic inflammation, oxidative stress, disturbances of lipid metabolism, immune pathways and secretions of bioactive molecules. Additionally, patients with psoriasis have an increased risk of developing autoimmune liver disease and also liver cancer in comparison to the heathy population. Moreover, drugs used in treatment of psoriasis and psoriatic arthritis augment the hepatotoxic effect on the liver. The study below presents the most recent data on the liver diseases and their pathogenesis in patients with psoriasis.
C1 [Kozlowska, Dorota; Mysliwiec, Hanna; Flisiak, Iwona] Med Univ Bialystok, Dept Dermatol & Venereol, Bialystok, Poland.
C3 Medical University of Bialystok
RP Kozlowska, D (corresponding author), Uniwersytet Med Bialymstoku, Klin Dermatol & Wenerol, Ul Zurawia 14, PL-15540 Bialystok, Poland.
EM dorota.kozlowska@umb.edu.pl
RI Kozłowska, Dorota/T-4060-2018; Flisiak, Iwona/R-5874-2018; Myśliwiec,
   Hanna/S-6326-2018
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NR 77
TC 1
Z9 1
U1 5
U2 9
PU TERMEDIA PUBLISHING HOUSE LTD
PI POZNAN
PA KLEEBERGA ST 2, POZNAN, 61-615, POLAND
SN 0033-2526
EI 2084-9893
J9 PRZ DERMATOL
JI Prz. Dermatol.
PY 2020
VL 107
IS 3
BP 257
EP 272
DI 10.5114/dr.2020.97819
PG 16
WC Dermatology
WE Emerging Sources Citation Index (ESCI)
SC Dermatology
GA NJ2GT
UT WOS:000565864500006
OA gold
DA 2025-06-11
ER

PT J
AU Zhang, XY
   Jin, QX
   Jin, LH
AF Zhang, Xiaoyue
   Jin, Qiuxia
   Jin, Li Hua
TI High sugar diet disrupts gut homeostasis though JNK and STAT pathways in
   Drosophila
SO BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
LA English
DT Article
DE High sugar diet; Intestinal stem cell; Commensal bacteria; Intestinal
   homeostasis; Drosophila melanogaster
ID INTESTINAL STEM-CELLS; LIFE-SPAN; INSULIN-RESISTANCE; METABOLIC
   SYNDROME; OXIDATIVE STRESS; MELANOGASTER; IMMUNITY; OBESITY; MIDGUT;
   ACTIVATION
AB The incidence of diseases associated with a high sugar diet has increased in the past years, and numerous studies have focused on the effect of high sugar intake on obesity and metabolic syndrome. However, how a high sugar diet influences gut homeostasis is still poorly understood. In this study, we used Drosophila melanogaster as a model organism and supplemented a culture medium with 1 M sucrose to create a high sugar condition. Our results indicate that a high sugar diet promoted differentiation of intestinal stem cells through upregulation of the JNK pathway and downregulation of the JAK/STAT pathway. Moreover, the number of commensal bacteria decreased in the high sugar group. Our data suggests that the high caloric diet disrupts gut homeostasis and highlights Drosophila as an ideal model system to explore gastrointestinal disease. (C) 2017 Elsevier Inc. All rights reserved.
C1 [Zhang, Xiaoyue; Jin, Qiuxia; Jin, Li Hua] Northeast Forestry Univ, Dept Genet, Coll Life Sci, Harbin, Peoples R China.
C3 Northeast Forestry University - China
RP Jin, LH (corresponding author), Northeast Forestry Univ, Dept Genet, Coll Life Sci, Harbin, Peoples R China.
EM lhjin2000@hotmail.com
FU National Natural Science Foundation of China [31270923]; Fundamental
   Research Funds for the Central Universities [2572016EAJ4]
FX We thank Rongwen Xi, Bruno Lemaitre, Jiwon Shim and Jose' Carlos
   Pastor-Pareja for the flies, the Bloomington and DGRC fly stock center
   and the TsingHua Fly Center for the fly stocks, the Developmental
   Studies Hybridoma Bank for providing the antibodies. This work was
   supported by grants from the National Natural Science Foundation of
   China [31270923] and the Fundamental Research Funds for the Central
   Universities [2572016EAJ4].
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NR 45
TC 27
Z9 33
U1 2
U2 103
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0006-291X
EI 1090-2104
J9 BIOCHEM BIOPH RES CO
JI Biochem. Biophys. Res. Commun.
PD JUN 10
PY 2017
VL 487
IS 4
BP 910
EP 916
DI 10.1016/j.bbrc.2017.04.156
PG 7
WC Biochemistry & Molecular Biology; Biophysics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics
GA EV6MO
UT WOS:000401883700023
PM 28476621
DA 2025-06-11
ER

PT J
AU Harskamp, RE
   Zeeman, GG
AF Harskamp, Ralf E.
   Zeeman, Gerda G.
TI Preeclampsia: At risk for remote cardiovascular disease
SO AMERICAN JOURNAL OF THE MEDICAL SCIENCES
LA English
DT Article
DE preeclampsia; cardiovascular disease; hypertension; metabolic syndrome
ID ISCHEMIC-HEART-DISEASE; OXIDATIVE STRESS; WOMEN; PREGNANCY;
   HYPERTENSION; HISTORY; STROKE; LIPOPROTEIN(A)
AB Epidemiological data indicate that women with preeclampsia are more likely to develop cardiovascular disease (CVD) later in life. Population-based studies relate preeclampsia to an increased risk of later chronic hypertension (RR, 2.00 to 8.00) and cardiovascular morbidity/mortality (RR, 1.3 to 3.07), compared with normotensive pregnancy. Women who develop preeclampsia before 36 weeks of gestation or have multiple hypertensive pregnancies are at highest risk (RR, 3.4 to 8.12). The underlying mechanism for the remote effects of preeclampsia is complex and probably multifactorial. Many risk factors are shared by CVD and preeclampsia, including endothelial dysfunction, obesity, hypertension, hyperglycemia, insulin resistance, and dyslipidemia. Therefore, it has been proposed that the metabolic syndrome may be a possible underlying mechanism common to CVD and preeclampsia. Follow-up and counseling of women with a history of preeclampsia may offer a window of opportunity for prevention of future disease.
C1 Univ Texas, Hlth Sci Ctr, San Antonio, TX 78229 USA.
   Univ Groningen, Univ Med Ctr Groningen, Dept Obstet & Gynecol, Groningen, Netherlands.
C3 University of Texas System; University of Texas Health Science Center at
   San Antonio; University of Groningen
RP Harskamp, RE (corresponding author), Univ Texas, Hlth Sci Ctr, 4900 Med Dr,504, San Antonio, TX 78229 USA.
EM r.e.harskamp@gmail.com
RI Harskamp, Ralf/A-9816-2009
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NR 34
TC 132
Z9 144
U1 0
U2 10
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0002-9629
EI 1538-2990
J9 AM J MED SCI
JI Am. J. Med. Sci.
PD OCT
PY 2007
VL 334
IS 4
BP 291
EP 295
DI 10.1097/MAJ.0b013e3180a6f094
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 222BO
UT WOS:000250271300011
PM 18030186
DA 2025-06-11
ER

PT J
AU Neri-Numa, IA
   Cazarin, CBB
   Ruiz, ALTG
   Paulino, BN
   Molina, G
   Pastore, GM
AF Neri-Numa, Iramaia Angelica
   Betim Cazarin, Cinthia Bau
   Tasca Gois Ruiz, Ana Lucia
   Paulino, Bruno Nicolau
   Molina, Gustavo
   Pastore, Glaucia Maria
TI Targeting flavonoids on modulation of metabolic syndrome
SO JOURNAL OF FUNCTIONAL FOODS
LA English
DT Review
DE Obesity; Insulin resistance; Type 2 diabetes; Cardiovascular diseases;
   Microbiota; Nutrigenetic
ID HIGH-FAT DIET; GUT MICROBIOTA; CARDIOVASCULAR-DISEASE; OXIDATIVE STRESS;
   BLOOD-PRESSURE; DOUBLE-BLIND; GREEN TEA; INTESTINAL MICROBIOTA;
   OVERWEIGHT SUBJECTS; INSULIN-RESISTANCE
AB Metabolic Syndrome (MetS) is a complex condition associated with cardiovascular risk factors and diabetes. The weight gain, especially the accumulation of central adipose tissue, may be the first leading cause of the MetS. It is important to highlight that the lifestyle choices considered as modifiable risk factors contribute to the increase in the incidence of the MetS in the population, such as sedentarism and food intake. There is evidence in the literature concerning the benefits associated with the Mediterranean diet, which is rich in polyphenols. Therefore, the flavonoids are a class of non-nutrient that can be extensively studied mainly to elucidate the mechanisms related to the action of these compounds in the modulation of the microbiota, DNA methylation and health improvement. Thus, this review summarized evidence linking flavonoid intake to obesity, insulin resistance, T2DM and cardiovascular diseases.
C1 [Neri-Numa, Iramaia Angelica; Pastore, Glaucia Maria] Univ Estadual Campinas, Fac Food Engn, Dept Food Sci, Lab Bioflavours & Bioact Cpds,UNICAMP, BR-13083862 Campinas, SP, Brazil.
   [Betim Cazarin, Cinthia Bau] Univ Estadual Campinas, Dept Food & Nutr, Nutr & Metab Lab, UNICAMP, BR-13083862 Campinas, SP, Brazil.
   [Tasca Gois Ruiz, Ana Lucia] Univ Estadual Campinas, Fac Pharmaceut Sci, UNICAMP, BR-13083871 Campinas, SP, Brazil.
   [Paulino, Bruno Nicolau] Fed Univ Amazonas UFAM, Fac Pharmaceut Sci, BR-69080900 Manaus, Amazonas, Brazil.
   [Molina, Gustavo] Fed Univ Jequitinhonha & Mucuri Valleys UFVJM, Inst Sci & Technol, Diamantina, MG, Brazil.
C3 Universidade Estadual de Campinas; Universidade Estadual de Campinas;
   Universidade Estadual de Campinas; Universidade Federal de Amazonas;
   Universidade Federal dos Vales do Jequitinhonha e Mucuri (UFVJM)
RP Neri-Numa, IA (corresponding author), Univ Estadual Campinas, Fac Food Engn, Dept Food Sci, Lab Bioflavours & Bioact Cpds, Monteiro Lobato St 80, BR-13083862 Campinas, SP, Brazil.
EM iramaia@unicamp.br
RI Paulino, Bruno/ABC-8664-2021; Numa, Iramaia/T-7472-2019; Molina,
   Gustavo/ABF-1526-2020; Ruiz, Ana Lucia/C-2249-2012; Bau Betim Cazarin,
   Cinthia/I-8837-2014
OI Bau Betim Cazarin, Cinthia/0000-0002-9849-2546; Tasca Gois Ruiz, Ana
   Lucia/0000-0002-0844-8702
FU National Council for Scientific and Technological Development (CNPq)
   [406820/2018-0]; Sao Paulo Research Foundation (FAPESP) [2015/50333-1];
   Minas Gerais Research Foundation (FAPEMIG) [APQ-01056-17]; Coordination
   for the Improvement of Higher Education Personnel (CAPES) [001]
FX The authors thank the National Council for Scientific and Technological
   Development (CNPq, grant numbers 406820/2018-0), Sao Paulo Research
   Foundation (FAPESP, grant number 2015/50333-1), Minas Gerais Research
   Foundation (FAPEMIG, grant number APQ-01056-17), and Coordination for
   the Improvement of Higher Education Personnel (CAPES, Finance Code 001)
   for their financial support.
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NR 199
TC 23
Z9 23
U1 0
U2 20
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1756-4646
EI 2214-9414
J9 J FUNCT FOODS
JI J. Funct. Food.
PD OCT
PY 2020
VL 73
AR 104132
DI 10.1016/j.jff.2020.104132
PG 18
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA OC9UN
UT WOS:000579501700050
OA gold
DA 2025-06-11
ER

PT J
AU Keenan, RT
   Pilinger, MH
AF Keenan, Robert T.
   Pilinger, Michael H.
TI FEBUXOSTAT: A NEW AGENT FOR LOWERING SERUM URATE
SO DRUGS OF TODAY
LA English
DT Article
ID PURINE SELECTIVE INHIBITOR; XANTHINE-OXIDASE INHIBITOR; URIC-ACID;
   METABOLIC SYNDROME; OXIDATIVE STRESS; NATIONAL-HEALTH; BLOOD-PRESSURE;
   CHRONIC GOUT; LONG-TERM; ALLOPURINOL
AB The prevalence of gout has been increasing in epidemic proportions over the last several decades. Hyperuricemia has been shown to be associated with metabolic syndrome and to be an independent risk factor for cardiovascular disease. Associations between hyperuricemia, obesity and aging have provided an impetus in recent years to develop alternative methods of treating hyperuricemia and gout. Febuxostat is a new non-purine xanthine oxidase inhibitor indicated for chronic gout. Febuxostat has been shown to quickly and effectively lower serum urate levels in patients with chronic gout. This manuscript will review febuxostat, its pharmacokinetics and pharmacodynamics, efficacy and adverse events and use in patients with comorbid conditions. The review will also summarize the phase Ill trials leading up to the drug's approval by both the European Commission in 2008 and the U.S. FDA in 2009. Possible implications the medication may have in the future on gout and hyperuricemia will also be discussed.
C1 [Keenan, Robert T.; Pilinger, Michael H.] NYU Hosp Joint Dis, Div Rheumatol, New York Harbor Vet Hlth Care Syst, New York, NY 10003 USA.
C3 New York University
RP Keenan, RT (corresponding author), NYU Hosp Joint Dis, Div Rheumatol, New York Harbor Vet Hlth Care Syst, 301 E 17th St,Room 1410,New York Campus, New York, NY 10003 USA.
EM Robert.keenan@nyumc.org
RI Keenan, Robert/JFT-0366-2023
OI Pillinger, Michael/0000-0003-3168-1542
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NR 68
TC 12
Z9 12
U1 0
U2 5
PU PROUS SCIENCE, SAU-THOMSON REUTERS
PI BARCELONA
PA 398 PROVENCA, 08025 BARCELONA, SPAIN
SN 1699-3993
EI 1699-4019
J9 DRUG TODAY
JI Drugs Today
PD APR
PY 2009
VL 45
IS 4
BP 247
EP 260
DI 10.1358/dot.2009.045.004.1354217
PG 14
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 652QJ
UT WOS:000282024400001
PM 19499090
DA 2025-06-11
ER

PT J
AU Paulin, R
   Dromparis, P
   Sutendra, G
   Gurtu, V
   Zervopoulos, S
   Bowers, L
   Haromy, A
   Webster, L
   Provencher, S
   Bonnet, S
   Michelakis, ED
AF Paulin, Roxane
   Dromparis, Peter
   Sutendra, Gopinath
   Gurtu, Vikram
   Zervopoulos, Sotirios
   Bowers, Lyndsay
   Haromy, Alois
   Webster, Linda
   Provencher, Steeve
   Bonnet, Sebastien
   Michelakis, Evangelos D.
TI Sirtuin 3 Deficiency Is Associated with Inhibited Mitochondrial Function
   and Pulmonary Arterial Hypertension in Rodents and Humans
SO CELL METABOLISM
LA English
DT Article
ID SMOOTH-MUSCLE-CELLS; INSULIN-RESISTANCE; DEOXYCORTICOSTERONE ACETATE;
   LYSINE ACETYLATION; METABOLIC SYNDROME; SKELETAL-MUSCLE; HYPOXIA; MICE;
   CHANNEL; STRESS
AB Suppression of mitochondrial function promoting proliferation and apoptosis suppression has been described in the pulmonary arteries and extrapulmonary tissues in pulmonary arterial hypertension (PAH), but the cause of this metabolic remodeling is unknown. Mice lacking sirtuin 3 (SIRT3), a mitochondrial deacetylase, have increased acetylation and inhibition of many mitochondrial enzymes and complexes, suppressing mitochondrial function. Sirt3KO mice develop spontaneous PAH, exhibiting previously described molecular features of PAH pulmonary artery smooth muscle cells (PASMC). In human PAH PASMC and rats with PAH, SIRT3 is downregulated, and its normalization with adenovirus gene therapy reverses the disease phenotype. A loss-of-function SIRT3 polymorphism, linked to metabolic syndrome, is associated with PAH in an unbiased cohort of 162 patients and controls. If confirmed in large patient cohorts, these findings may facilitate biomarker and therapeutic discovery programs in PAH.
C1 [Paulin, Roxane; Dromparis, Peter; Sutendra, Gopinath; Gurtu, Vikram; Zervopoulos, Sotirios; Bowers, Lyndsay; Haromy, Alois; Webster, Linda; Michelakis, Evangelos D.] Univ Alberta, Dept Med, Edmonton, AB T6G 2B7, Canada.
   [Provencher, Steeve; Bonnet, Sebastien] Univ Laval, Dept Med, IUCPQ Res Ctr, Pulm Hypertens Res Grp, Quebec City, PQ G1V 4G5, Canada.
C3 University of Alberta; Laval University
RP Michelakis, ED (corresponding author), Univ Alberta, Dept Med, Edmonton, AB T6G 2B7, Canada.
EM em2@ualberta.ca
RI Zervopoulos, Sotirios/E-3200-2016; Gurtu, Vikram/G-5299-2016
OI Michelakis, Evangelos/0000-0003-0787-7721; Zervopoulos,
   Sotirios/0000-0002-2958-9053
FU Canadian Institutes for Health Research; Alberta Innovates-Health
   Solutions; Alberta Innovates-Health Solutions, a Canada Research Chair;
   Mazankowski Alberta Heart Institute/University Hospital Foundation
FX R.P. is funded by Canadian Institutes for Health Research and Alberta
   Innovates-Health Solutions postdoctoral fellowships. E. D. M. is funded
   by the Canadian Institutes for Health Research, which funded this work,
   the Alberta Innovates-Health Solutions, a Canada Research Chair (Tier I)
   in applied molecular and mitochondrial medicine, and by a grant from the
   Mazankowski Alberta Heart Institute/University Hospital Foundation.
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NR 58
TC 165
Z9 184
U1 0
U2 22
PU CELL PRESS
PI CAMBRIDGE
PA 50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA
SN 1550-4131
EI 1932-7420
J9 CELL METAB
JI Cell Metab.
PD NOV 4
PY 2014
VL 20
IS 5
BP 827
EP 839
DI 10.1016/j.cmet.2014.08.011
PG 13
WC Cell Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Endocrinology & Metabolism
GA AT4YF
UT WOS:000344947800018
PM 25284742
DA 2025-06-11
ER

PT J
AU Lavagnino, L
   Amianto, F
   Caprino, MP
   Maccario, M
   Arvat, E
   Ghigo, E
   Daga, GA
   Fassino, S
AF Lavagnino, Luca
   Amianto, Federico
   Caprino, Mirko Parasiliti
   Maccario, Mauro
   Arvat, Emanuela
   Ghigo, Ezio
   Daga, Giovanni Abbate
   Fassino, Secondo
TI Urinary cortisol and psychopathology in obese binge eating subjects
SO APPETITE
LA English
DT Article
DE Binge eating; HPA axis; Stress; Obesity
ID PITUITARY-ADRENAL AXIS; POSTTRAUMATIC-STRESS-DISORDER; METABOLIC
   SYNDROME; COMFORT FOOD; WOMEN; PATHOPHYSIOLOGY; HYPOCORTISOLISM;
   FIBROMYALGIA; VALIDATION; EXPOSURE
AB Background: Investigations on the relationship between obesity, binge eating and the function of hypothalamic-pituitary-adrenal (HPA) aids have led to inconsistent results. General psychopathology affects HPA axis function. The present study aims to examine correlations between binge eating, general psychopathology and HPA axis function in obese binge eaters. Methods: Twenty-four hour urinary free cortisol (UFC/24 h) was measured in 71 obese binge eating women. The patients were administered psychometric tests investigating binge eating, psychopathology and clinical variables. The relationship between binge eating, psychopathology and urinary cortisol was investigated, controlling for age and BMI. Results: We found an inverse correlation between UFC/24 h and binge eating, depression, obsessive-compusive symptoms, somatization and sensitivity. In a regression model a significant inverse correlation between urinary cortisol and psychopathology was confirmed. Conclusions: Urinary cortisol levels in obese patients with binge eating disorder show an inverse correlation with several dimensions of psychopathology which are considered to be typical of a cluster of psychiatric disorders characterized by low HPA axis function, and are very common in obese binge eating patients. If these results are confirmed, UFC/24 h might be considered a biomarker of psychopathology in obese binge eaters. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Lavagnino, Luca; Amianto, Federico; Daga, Giovanni Abbate; Fassino, Secondo] Univ Turin, Reg Pilot Ctr Eating Disorders, Psychiat Sect, Dept Neurosci, I-10124 Turin, Italy.
   [Caprino, Mirko Parasiliti; Maccario, Mauro; Arvat, Emanuela; Ghigo, Ezio] Univ Turin, Dept Med Sci, Div Endocrinol Diabetol & Metab, I-10124 Turin, Italy.
C3 University of Turin; University of Turin
RP Lavagnino, L (corresponding author), Univ Turin, Reg Pilot Ctr Eating Disorders, Psychiat Sect, Dept Neurosci, I-10124 Turin, Italy.
EM luca.lavagnino1977@gmail.com
RI Parasiliti-Caprino, Mirko/ABB-2735-2020; Abbate Daga,
   Giovanni/AAE-3155-2022
OI ARVAT, Emanuela/0000-0001-5689-4400; Abbate-Daga,
   Giovanni/0000-0002-5826-5664; Parasiliti-Caprino,
   Mirko/0000-0002-6930-7073
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NR 46
TC 11
Z9 13
U1 1
U2 15
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 0195-6663
EI 1095-8304
J9 APPETITE
JI Appetite
PD DEC 1
PY 2014
VL 83
BP 112
EP 116
DI 10.1016/j.appet.2014.08.020
PG 5
WC Behavioral Sciences; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Behavioral Sciences; Nutrition & Dietetics
GA AT3GP
UT WOS:000344824200016
PM 25149200
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Ramirez, ND
   Luque, EM
   Jones, XM
   Torres, PJ
   Espinoza, MJM
   Cantarelli, V
   Ponzio, MF
   Arja, A
   Rabaglino, MB
   Martini, AC
AF David Ramirez, Nicolas
   Mercedes Luque, Eugenia
   Michael Jones, Xaviar
   Javier Torres, Pedro
   Moreira Espinoza, Maria Jose
   Cantarelli, Veronica
   Flavia Ponzio, Marina
   Arja, Ana
   Belen Rabaglino, Maria
   Carolina Martini, Ana
TI Modulatory effects of ghrelin on sperm quality alterations induced by a
   fructose-enriched diet
SO HELIYON
LA English
DT Article
DE Cell biology; Developmental biology; Molecular biology; Diet;
   Endocrinology; Metabolic syndrome; Epididymis; Glutathione peroxidase;
   Oxidative stress; Neutral alpha-glucosidase
ID METABOLIC SYNDROME; OXIDATIVE STRESS; ANDROGEN ACTION; IN-VITRO;
   EXPRESSION; SPERMATOZOA; EPIDIDYMIS; HYPOXIA; OBESITY; LEPTIN
AB The objectives of this study were: 1) to evaluate the effects of a fructose enriched diet (FED) on rat sperm quality, epididymal function (i.e. oxidative stress and alpha-glucosidase expression) and testosterone concentrations; 2) to determine if the administration of ghrelin (Ghrl), reverses the effects induced by FED.
   After validating the protocol as an inductor of metabolic syndrome like-symptoms, adult male rats were assigned to one of the following treatments for 8 weeks: FED = 10% fructose enriched in water (v/v); FED + Ghrl = fructose enriched diet plus Ghrl (6 nmol/animal/day, s.c.) from week 6-8; or C = water without fructose (n = 5-10 animals/group).
   FED significantly decreased sperm concentration and motile sperm count/ml vs C (FED: 19.0 +/- 1.6 x 10(6)sperm/ml and 834.6 +/- 137.0, respectively vs C: 25.8 +/- 2.8 x 10(6) and 1300.4 +/- 202.4, respectively; p < 0.05); ghrelin injection reversed this negative effect (23.5 + 1.6 x 10(6)sperm/ml and 1381.7 +/- 71.3 respectively). FED resulted in hypogonadism, but Ghrl could not normalize testosterone concentrations (C: 1.4 +/- 0.1 ng/ml vs FED: 0.8 +/- 0.2 ng/ml and FED + Ghrl: 0.6 +/- 0.2 ng/ml; p < 0.05). Ghrelin did not reverse metabolic abnormalities secondary to FED. FED did not alter epididymal expression of antioxidants enzymes (superoxido-dismutase, catalase and glutathione peroxidases -Gpx-). Nevertheless, FED + Ghrl significantly increased the expression of Gpx3 (FED + Ghrl: 3.47 +/- 0.48 vs FED: 0.69 +/- 0.28 and C: 1.00 +/- 0.14; p < 0.05). The expression of neutral alpha-glucosidase, which is a marker of epididymal function, did not differ between treatments.
   In conclusion, the administration of Ghrl modulated the negative effects of FED on sperm quality, possibly by an epididymal increase in Gpx3 expression. However, Ghrl could not neither normalize the metabolism of FED animals, nor reverse hypogonadism.
C1 [David Ramirez, Nicolas; Mercedes Luque, Eugenia; Michael Jones, Xaviar; Javier Torres, Pedro; Cantarelli, Veronica; Flavia Ponzio, Marina; Arja, Ana; Carolina Martini, Ana] Univ Nacl Cordoba, Inst Fisiol, Fac Ciencias Med, Santa Rosa 1085,X5000ESU, Cordoba, Argentina.
   [Javier Torres, Pedro; Cantarelli, Veronica; Flavia Ponzio, Marina; Belen Rabaglino, Maria; Carolina Martini, Ana] Univ Nacl Cordoba, Inst Invest Ciencias Salud INICSA, CONICET, Fac Ciencias Med, Pabellon Biol Celular,Ciudad Univ, RA-5016 Cordoba, Argentina.
   [Moreira Espinoza, Maria Jose] Univ Nacl Cordoba, Fac Ciencias Med, Inst Biol Celular, Ciudad Univ, RA-5016 Cordoba, Argentina.
C3 National University of Cordoba; Consejo Nacional de Investigaciones
   Cientificas y Tecnicas (CONICET); National University of Cordoba;
   National University of Cordoba
RP Martini, AC (corresponding author), Univ Nacl Cordoba, Inst Fisiol, Fac Ciencias Med, Santa Rosa 1085,X5000ESU, Cordoba, Argentina.; Martini, AC (corresponding author), Univ Nacl Cordoba, Inst Invest Ciencias Salud INICSA, CONICET, Fac Ciencias Med, Pabellon Biol Celular,Ciudad Univ, RA-5016 Cordoba, Argentina.
EM acmartini2000@yahoo.com
RI Cantarelli, Verónica/H-5414-2018
OI Arja, Ahmed/0009-0007-4001-7041; Rabaglino, Maria
   Belen/0000-0002-0099-045X; Jones, Xaviar/0000-0003-1815-4166;
   Moreira-Espinoza, Maria Jose/0000-0003-2398-296X; Cantarelli, Veronica
   Ines/0000-0002-2974-886X
FU Secretaria de Ciencia y Tecnologia, Universidad Nacional de Cordoba
   (SECyT-UNC)
FX This work was supported by grants from the Secretaria de Ciencia y
   Tecnologia, Universidad Nacional de Cordoba (SECyT-UNC).
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NR 53
TC 6
Z9 6
U1 0
U2 1
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
EI 2405-8440
J9 HELIYON
JI Heliyon
PD NOV
PY 2019
VL 5
IS 11
AR e02886
DI 10.1016/j.heliyon.2019.e02886
PG 6
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA JS8CO
UT WOS:000500530100139
PM 31844755
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Chang, CC
   Chen, PS
   Lin, JR
   Chen, YA
   Liu, CS
   Lin, TT
   Chang, HH
AF Chang, Cheng-Chen
   Chen, Po See
   Lin, Jhih-Rong
   Chen, Yi-An
   Liu, Chin-San
   Lin, Ta-Tsung
   Chang, Hui Hua
TI Mitochondrial DNA Copy Number Is Associated With Treatment Response and
   Cognitive Function in Euthymic Bipolar Patients Receiving Valproate
SO INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
LA English
DT Article
DE Bipolar disorder; cognitive function; metabolic syndrome; mitochondrial
   DNA copy number; valproate
ID METABOLIC SYNDROME; IMPAIRMENT; DISORDER; DYSFUNCTION; DEPRESSION;
   DEFICITS; LITHIUM; BLOOD; ACID
AB Background Bipolar disorder (BD) is associated with cognitive impairment and mitochondrial dysfunction. However, the associations among mitochondrial DNA copy number (MCN), treatment response, and cognitive function remain elusive in BD patients. Methods Sixty euthymic BD patients receiving valproate (VPA) and 66 healthy controls from the community were recruited. The indices of metabolic syndrome (MetS) were measured. Quantitative polymerase chain reaction analysis of blood leukocytes was used to measure the MCN. Cognitive function was measured by calculating perseverative errors and completed categories on the Wisconsin Card Sorting Test (WCST). The VPA treatment response was measured using the Alda scale. Results BD patients had significantly higher MCN, triglyceride, and C-reactive protein (CRP) levels, waist circumference, and worse performance on the WCST than the controls. Regression models showed that BD itself and the VPA concentration exerted significant effects on increased MCN levels. Moreover, the receiver operating characteristic curve analysis showed that an MCN of 2.05 distinguished VPA responders from nonresponders, with an area under the curve of 0.705 and a sensitivity and specificity of 0.529 and 0.816, respectively. An MCN level >= 2.05 was associated with 5.39 higher odds of being a VPA responder (P = .006). BD patients who were stratified into the high-MCN group had a higher VPA response rate, better WCST performance, lower CRP level, and less MetS. Conclusions The study suggests a link between the peripheral MCN and cognitive function in BD patients. As an inflammatory status, MetS might modulate this association.
C1 [Chang, Cheng-Chen] Chung Shan Med Univ, Sch Med, Taichung, Taiwan.
   [Chang, Cheng-Chen] Chung Shan Med Univ Hosp, Dept Psychiat, Taichung, Taiwan.
   [Chen, Po See] Natl Cheng Kung Univ, Coll Med, Dept Psychiat, Tainan, Taiwan.
   [Chen, Po See] Natl Cheng Kung Univ, Coll Med, Inst Behav Med, Tainan, Taiwan.
   [Lin, Jhih-Rong; Chen, Yi-An; Chang, Hui Hua] Natl Cheng Kung Univ, Coll Med, Inst Clin Pharm & Pharmaceut Sci, Tainan, Taiwan.
   [Liu, Chin-San; Lin, Ta-Tsung] Changhua Christian Hosp, Vasc & Genom Res Ctr, Changhua, Taiwan.
   [Liu, Chin-San] China Med Univ, Coll Chinese Med, Grad Inst Integrated Med, Taichung, Taiwan.
   [Chang, Hui Hua] Natl Cheng Kung Univ, Coll Med, Sch Pharm, Tainan, Taiwan.
   [Chang, Hui Hua] Natl Cheng Kung Univ, Natl Cheng Kung Univ Hosp, Coll Med, Dept Pharm, Tainan, Taiwan.
   [Chang, Hui Hua] Natl Cheng Kung Univ Hosp, Dept Pharm, Dou Liou Branch, Touliu, Yunlin, Taiwan.
C3 Chung Shan Medical University; Chung Shan Medical University; Chung Shan
   Medical University Hospital; National Cheng Kung University; National
   Cheng Kung University; National Cheng Kung University; Changhua
   Christian Hospital; China Medical University Taiwan; National Cheng Kung
   University; National Cheng Kung University; National Cheng Kung
   University Hospital; National Cheng Kung University; National Cheng Kung
   University Hospital
RP Chang, HH (corresponding author), Natl Cheng Kung Univ, Inst Clin Pharm & Pharmaceut Sci, 1 Univ Rd, Tainan 701, Taiwan.
EM huihua@mail.ncku.edu.tw
RI Chang, Hui/AGD-4270-2022; é™³, ç‘žå‚‘/HCH-5712-2022; Chen,
   Po/AAA-6492-2021
OI Chang, Hui Hua/0000-0001-7866-5481
FU Ministry of Science and Technology of Taiwan [MOST 105-2320-B-006-014,
   MOST 106-2320-B-006-040, MOST 107-2320-B-006-071, MOST
   108-2320-B-006-047-MY3]; National Cheng Kung University Hospital
   [NCKUH-10802013, NCKUH-10902014, NCKUH-11002026]; Changhua Christian
   Hospital [108-CCH-IRP-109]
FX We thank all the participants of this study for their exceptional
   cooperation as well as valuable contributions. We also thank Chih-Ying
   Lin for administrative support. This work was supported by the Ministry
   of Science and Technology of Taiwan (MOST 105-2320-B-006-014, MOST
   106-2320-B-006-040, MOST 107-2320-B-006-071, MOST
   108-2320-B-006-047-MY3); the National Cheng Kung University Hospital
   (NCKUH-10802013, NCKUH-10902014, NCKUH-11002026); and the Changhua
   Christian Hospital (108-CCH-IRP-109).
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NR 53
TC 7
Z9 7
U1 0
U2 5
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1461-1457
EI 1469-5111
J9 INT J NEUROPSYCHOPH
JI Int. J. Neuropsychopharmacol.
PD AUG 4
PY 2022
VL 25
IS 7
BP 525
EP 533
DI 10.1093/ijnp/pyab095
EA JAN 2022
PG 9
WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA 3N8OX
UT WOS:000756736900001
PM 34979555
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Dodd, S
   Carvalho, AF
   Puri, BK
   Maes, M
   Bortolasci, CC
   Morris, G
   Berk, M
AF Dodd, Seetal
   Carvalho, Andre F.
   Puri, Basant K.
   Maes, Michael
   Bortolasci, Chiara C.
   Morris, Gerwyn
   Berk, Michael
TI Trace Amine-Associated Receptor 1 (TAAR1): A new drug target for
   psychiatry?
SO NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
LA English
DT Review
DE Trace Amine-Associated Receptor; SEP-363856; schizophrenia; drug target
AB There are nine subfamilies of TAARs. They are predominantly intracellular, located in the central nervous system and peripherally. They have a role in homeostasis and rheostasis, and also in olfaction. They demonstrate significant cross-talk with the monoamine system and are involved in the regulation of cAMP signalling and K+ channels. There is evidence to suggest that TAAR1 may be a promising therapeutic target for the treatment of schizophrenia, psychosis in Parkinson's disease, substance use disorders, and the metabolic syndrome and obesity. TAAR1 expression may also be a prognostic biomarker for cancers.
   A number of TAAR modulators have been identified, including endogenous ligands and new chemical entities. Some of these agents have shown efficacy in animal models of addiction behaviours, depression and anxiety. Only one agent, SEP-363856, has progressed to randomised clinical trials in humans; however further, larger studies with SEP-363856 are required to clarify its suitability as a new treatment for schizophrenia spectrum disorders. SEP-363856 is an agonist of TAAR1 and 5HT1A and it is not clear to what extent its efficacy can be attributed to TAAR1 rather than to other drug targets. However, current research suggests that TAAR1 has an important role in human physiology and pathophysiology. TAAR1 modulators may become an important new drug class for the management of a wide array of mental disorders in the future.
C1 [Dodd, Seetal; Carvalho, Andre F.; Maes, Michael; Bortolasci, Chiara C.; Morris, Gerwyn; Berk, Michael] Deakin Univ, Inst Mental & Phys Hlth & Clin Translat, Geelong, Vic, Australia.
   [Dodd, Seetal; Berk, Michael] Univ Melbourne, Ctr Youth Mental Hlth, Parkville, Vic, Australia.
   [Dodd, Seetal; Berk, Michael] Univ Melbourne, Dept Psychiat, Parkville, Vic, Australia.
   [Dodd, Seetal; Berk, Michael] Univ Hosp Geelong, Barwon Hlth, POB 281, Geelong, Vic 3220, Australia.
   [Carvalho, Andre F.] Ctr Addict & Mental Hlth CAMH, Toronto, ON, Canada.
   [Carvalho, Andre F.] Dept Psychiat, Toronto, ON, Canada.
   [Puri, Basant K.] CAR, Cambridge, England.
   [Bortolasci, Chiara C.] Deakin Univ, Sch Med, Ctr Mol & Med Res, Geelong, Vic, Australia.
C3 Deakin University; University of Melbourne; Orygen, The National Centre
   of Excellence in Youth Mental Health; University of Melbourne; Barwon
   Health; Geelong Hospital; University of Toronto; Centre for Addiction &
   Mental Health - Canada; Deakin University
RP Dodd, S (corresponding author), Deakin Univ, Inst Mental & Phys Hlth & Clin Translat, Barwon Hlth, POB 281, Geelong, Vic 3220, Australia.
EM seetald@barwonhealth.org.au
RI Carvalho, Andre/AEZ-4001-2022; Bortolasci, Chiara/C-7336-2016; Puri,
   Basant/H-8249-2019; Berk, Michael/AGH-9427-2022; Maes,
   Michael/B-8546-2011; Berk, Michael/M-7891-2013
OI Puri, Basant/0000-0001-6101-0139; Berk, Michael/0000-0002-5554-6946
FU National Health and Medical Research Council (NHMRC) Senior Principal
   Research Fellowship [APP1059660, APP1156072]
FX MB is supported by a National Health and Medical Research Council
   (NHMRC) Senior Principal Research Fellowship (APP1059660 and APP1156072)
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NR 42
TC 40
Z9 44
U1 0
U2 30
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0149-7634
EI 1873-7528
J9 NEUROSCI BIOBEHAV R
JI Neurosci. Biobehav. Rev.
PD JAN
PY 2021
VL 120
BP 537
EP 541
DI 10.1016/j.neubiorev.2020.09.028
EA JAN 2021
PG 5
WC Behavioral Sciences; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Behavioral Sciences; Neurosciences & Neurology
GA QB6VG
UT WOS:000614277700003
PM 33031817
DA 2025-06-11
ER

PT J
AU Lamar, M
   Rubin, LH
   Ajilore, O
   Charlton, R
   Zhang, AF
   Yang, SL
   Cohen, J
   Kumar, A
AF Lamar, Melissa
   Rubin, Leah H.
   Ajilore, Olusola
   Charlton, Rebecca
   Zhang, Aifeng
   Yang, Shaolin
   Cohen, Jamie
   Kumar, Anand
TI What Metabolic Syndrome Contributes to Brain Outcomes in African
   American & Caucasian Cohorts
SO CURRENT ALZHEIMER RESEARCH
LA English
DT Article
DE Affect; aging; cognition; health disparities; metabolic syndrome;
   neuroanatomy; vascular risk
ID ALZHEIMERS-DISEASE; RISK-FACTORS; COGNITIVE PERFORMANCE; PREFRONTAL
   CORTEX; VASCULAR RISK; MEMORY; ADULTS; ASSOCIATION; IMPAIRMENT;
   DEPRESSION
AB Metabolic syndrome (MetS), i.e., meeting criteria for any three of the following: hyperglycemia, hypertension, hypertriglyceridemia, low high-density lipoprotein and/or abdominal obesity, is associated with negative health outcomes. For example, MetS negatively impacts cognition; however, less is known about incremental MetS risk, i.e., meeting 1 or 2 as opposed to 3 or more criteria. We hypothesized incremental MetS risk would negatively contribute to cognition and relevant neuroanatomy, e.g., memory and hippocampal volumes, and that this risk extends to affective functioning. 119 non-demented/non-depressed participants (age=60.1+12.9;similar to 50% African American) grouped by incremental MetSrisk-no (0 criteria met), low (1-2 criteria met), or high (3+ criteria met)-were compared across cognition, affect and relevant neuroanatomy using multivariable linear regressions. Exploratory analyses, stratified by race, consider the role of health disparities in disease severity of individual MetS component (e.g., actual blood pressure readings) on significant results from primary analyses. Incremental MetS risk contributed to depressive symptomatology (no<low<high), learning and memory performance (no>low=high) after controlling for age, race (n.s.) and IQ. Different indices of disease severity contributed to different aspects of brain structure and function by race providing empirical support for future studies of the impact distinct health disparities in vascular risk have on brain aging. MetS compromised mood, cognition and hippocampal structure with incremental risk applying to some but not all of these outcomes. Care providers may wish to monitor a broader spectrum of risk including components of MetS like blood pressure and cholesterol levels when considering brain-behavior relationships in adults from diverse populations.
C1 [Lamar, Melissa; Rubin, Leah H.; Ajilore, Olusola; Charlton, Rebecca; Zhang, Aifeng; Yang, Shaolin; Cohen, Jamie; Kumar, Anand] Univ Illinois, Dept Psychiat, Chicago, IL 60612 USA.
   [Charlton, Rebecca] Univ London, Dept Psychol, London WC1E 7HU, England.
C3 University of Illinois System; University of Illinois Chicago;
   University of Illinois Chicago Hospital; University of London
RP Lamar, M (corresponding author), Univ Illinois, 1601 West Taylor St MC912, Chicago, IL 60612 USA.
EM mlamar@psych.uic.edu
RI Yang, Shaolin/NHP-2672-2025; Ajilore, Olusola/ABG-4035-2020; Ajilore,
   Olusola/A-1073-2011
OI Peven, Jamie/0000-0002-2187-5514; Ajilore, Olusola/0000-0003-0737-0437;
   Charlton, Rebecca/0000-0002-3326-8762
FU National Institue on Aging [K01 AG040192]; National Institute of Mental
   Health [7RO1 MH073989-04, K23 MH011875]
FX This work was suppoorted by the National Institue on Aging [K01 AG040192
   to M.L.] and the National Institute of Mental Health [grant numbers 7RO1
   MH073989-04 to A.K., K23 MH011875 to O.A.].
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NR 59
TC 22
Z9 22
U1 0
U2 7
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1567-2050
EI 1875-5828
J9 CURR ALZHEIMER RES
JI Curr. Alzheimer Res.
PY 2015
VL 12
IS 7
BP 640
EP 647
DI 10.2174/1567205012666150701102325
PG 8
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA CN9RB
UT WOS:000358785400006
PM 26239040
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Stankiewicz, AJ
   McGowan, EM
   Yu, LL
   Zhdanova, IV
AF Stankiewicz, Alexander J.
   McGowan, Erin M.
   Yu, Lili
   Zhdanova, Irina V.
TI Impaired Sleep, Circadian Rhythms and Neurogenesis in Diet-Induced
   Premature Aging
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE premature aging; circadian; neurogenesis; sleep; high caloric intake;
   cell cycle; scoliosis; anxiety; diurnal vertebrate
ID CALORIC RESTRICTION; ADULT ZEBRAFISH; CARDIOMETABOLIC RISK;
   GLUCOSE-METABOLISM; DENTATE GYRUS; WEIGHT-LOSS; CLOCK GENE; LIFE-SPAN;
   OBESITY; DURATION
AB Chronic high caloric intake (HCI) is a risk factor for multiple major human disorders, from diabetes to neurodegeneration. Mounting evidence suggests a significant contribution of circadian misalignment and sleep alterations to this phenomenon. An inverse temporal relationship between sleep, activity, food intake, and clock mechanisms in nocturnal and diurnal animals suggests that a search for effective therapeutic approaches can benefit from the use of diurnal animal models. Here, we show that, similar to normal aging, HCI leads to the reduction in daily amplitude of expression for core clock genes, a decline in sleep duration, an increase in scoliosis, and anxiety-like behavior. A remarkable decline in adult neurogenesis in 1-year old HCI animals, amounting to only 21% of that in age-matched Control, exceeds age-dependent decline observed in normal 3-year old zebrafish. This is associated with misalignment or reduced amplitude of daily patterns for principal cell cycle regulators, cyclins A and B, and p20, in brain tissue. Together, these data establish HCI in zebrafish as a model for metabolically induced premature aging of sleep, circadian functions, and adult neurogenesis, allowing for a high throughput approach to mechanistic studies and drug trials in a diurnal vertebrate.
C1 [Stankiewicz, Alexander J.; Yu, Lili; Zhdanova, Irina V.] BioChron LLC, Dept Preclin Res & Dev, Worcester, MA 01605 USA.
   [Stankiewicz, Alexander J.; McGowan, Erin M.; Yu, Lili; Zhdanova, Irina V.] Boston Univ, Sch Med, Dept Anat & Neurobiol, Boston, MA 02118 USA.
C3 Boston University
RP Zhdanova, IV (corresponding author), BioChron LLC, Dept Preclin Res & Dev, Worcester, MA 01605 USA.; Zhdanova, IV (corresponding author), Boston Univ, Sch Med, Dept Anat & Neurobiol, Boston, MA 02118 USA.
EM erinmcgowan20@gmail.com; lilifish1964@gmail.com;
   irina.zhdanova@bio-chron.com
OI McGowan, Erin/0000-0003-0054-1555
FU Chaikin-Wile Foundation
FX This work was supported by a grant from the Chaikin-Wile Foundation. We
   authors are grateful to Vickery Trinkaus-Randall (Boston University
   School of Medicine, Boston, MA, USA), Tarik Haydar (Boston University
   School of Medicine, Boston, MA, USA) and Nadine Aziz (Boston University
   School of Medicine, Boston, MA, USA) for help with confocal imaging,
   generous share of the cell counting software, and useful discussions. We
   thank Jason Best (Boston Children's Hospital, Boston, MA, USA), Aga
   Bereznicka (Boston University, Boston, MA, USA), and Christine Cincotta
   (Boston University, Boston, MA, USA) for help with zebrafish maintenance
   and excellent technical assistance.
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NR 84
TC 18
Z9 19
U1 1
U2 15
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD NOV
PY 2017
VL 18
IS 11
AR 2243
DI 10.3390/ijms18112243
PG 15
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA FO4KK
UT WOS:000416811300017
PM 29072584
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Poteat, T
   Gallo, LC
   Harkness, A
   Isasi, CR
   Matthews, P
   Schneiderman, N
   Thyagarajan, B
   Daviglus, ML
   Sotres-Alvarez, D
   Perreira, KM
AF Poteat, Tonia
   Gallo, Linda C.
   Harkness, Audrey
   Isasi, Carmen R.
   Matthews, Phoenix
   Schneiderman, Neil
   Thyagarajan, Bharat
   Daviglus, Martha L.
   Sotres-Alvarez, Daniela
   Perreira, Krista M.
TI Influence of Stress, Gender, and Minority Status on Cardiovascular
   Disease Risk in the Hispanic/Latino Community: Protocol for a
   Longitudinal Observational Cohort Study
SO JMIR RESEARCH PROTOCOLS
LA English
DT Article
DE minority stress; cardiovascular disease; sexual and gender minorities;
   transgender; intersex; lesbian; bisexual; gay; Hispanic; Latino
ID SEXUAL ORIENTATION; METABOLIC SYNDROME; PERCEIVED DISCRIMINATION;
   HEALTH-STATUS; MYOCARDIAL-INFARCTION; MENTAL-HEALTH; 52 COUNTRIES;
   ADULTS; HISPANICS/LATINOS; PREVALENCE
AB Background: Hispanic/Latino sexual and gender minorities (SGM) are the fastest growing ethnic group of SGM in the United States. Cardiovascular disease (CVD) is a leading cause of morbidity and mortality among Hispanics/Latinos. SGM inequities in CVD risk have been identified as early as young adulthood, and minority stress has been identified as a potential mediator. Yet, the small number of ethnic or racial minority participants in SGM studies have precluded the examination of the intersections of sexual orientation, gender identity, and race and ethnicity.
   Objective: Minority stress models conceptualize relationships between stressors in minority groups and health outcomes. In this study, we will (1) examine the influence of sexual orientation and gender identity on CVD risk among all Hispanic Community Health Study/Study of Latinos (HCHS/SOL) participants at visit 3 (2021-2024; N similar to 9300); (2) model pathways from sexual orientation and gender identity to CVD risk through stigma, discrimination, and stress in a 1:2 matched subcohort of SGM and non-SGM participants at visit 3 (n similar to 1680); and (3) examine the influence of resilience factors on sexual orientation or gender identity and CVD risk relationships among subcohort participants at visit 3 (n similar to 1680).
   Methods: This study will leverage existing data from the parent HCHS/SOL study (collected since 2008) while collecting new data on sexual orientation, gender identity, stigma, discrimination, stress, coping, social support, and CVD risk. Data analysis will follow the SGM minority stress model, which states that excess stigma against SGM populations leads to minority stress that increases CVD risk. In this model, coping and social support serve as resilience factors that can mitigate the impact of minority stress on CVD risk. Cross-sectional and longitudinal regression models as well as structural equation models will be used to test these relationships.
   Results: This study was funded by the National Heart, Lung, and Blood Institute in March 2020. Recruitment is scheduled to begin in the first quarter of 2021 and continue through 2024.
   Conclusions: Understanding the influence of stigma-induced stress on CVD risk among Hispanic/Latino SGM has significant implications for the development of culturally specific CVD risk reduction strategies. Study findings will be used to build on identified Hispanic/Latino cultural strengths to inform adaptation and testing of family and community acceptance interventions.
C1 [Poteat, Tonia; Perreira, Krista M.] Univ N Carolina, Sch Med, Dept Social Med, MacNider Hall,333 South Columbia St,Room 345B, Chapel Hill, NC 27599 USA.
   [Gallo, Linda C.] San Diego State Univ, Dept Psychol, San Diego, CA 92182 USA.
   [Harkness, Audrey] Univ Miami, Dept Publ Hlth Sci, Miami, FL USA.
   [Isasi, Carmen R.] Albert Einstein Coll Med, Dept Epidemiol & Populat Hlth, New York, NY USA.
   [Matthews, Phoenix] Univ Illinois, Dept Populat Hlth Nursing Sci, Chicago, IL USA.
   [Schneiderman, Neil] Univ Miami, Dept Psychol, Miami, FL USA.
   [Thyagarajan, Bharat] Univ Minnesota, Dept Lab Med & Pathol, Minneapolis, MN 55455 USA.
   [Daviglus, Martha L.] Univ Illinois, Coll Med, Inst Minor Hlth Res, Chicago, IL USA.
   [Sotres-Alvarez, Daniela] Univ N Carolina, Dept Biostat, Chapel Hill, NC 27599 USA.
C3 University of North Carolina School of Medicine; University of North
   Carolina; University of North Carolina Chapel Hill; California State
   University System; San Diego State University; University of Miami;
   Yeshiva University; University of Illinois System; University of
   Illinois Chicago; University of Illinois Chicago Hospital; University of
   Miami; University of Minnesota System; University of Minnesota Twin
   Cities; University of Illinois System; University of Illinois Chicago;
   University of Illinois Chicago Hospital; University of North Carolina;
   University of North Carolina Chapel Hill
RP Poteat, T (corresponding author), Univ N Carolina, Sch Med, Dept Social Med, MacNider Hall,333 South Columbia St,Room 345B, Chapel Hill, NC 27599 USA.
EM tonia.poteat@med.unc.edu
RI Sotres-Alvarez, Daniela/O-9085-2016; Harkness, Audrey/ABG-1920-2021;
   Matthews, Alicia/R-4704-2018
OI Matthews, Alicia/0000-0002-0074-681X; Thyagarajan,
   Bharat/0000-0001-6968-6985; Gallo, Linda C./0000-0002-3678-5888; Isasi,
   Carmen R/0000-0003-2700-9593; Schneiderman, Neil/0000-0002-7982-068X;
   Perreira, Krista/0000-0003-2906-0261; Harkness,
   Audrey/0000-0003-2290-9904; Poteat, Tonia/0000-0001-6541-3787
FU National Heart Blood and Lung Institute [R01HL149778]; National Heart,
   Lung, and Blood Institute (NHLBI) [HHSN268201300001I/N01HC65233,
   HHSN268201300004I/N01HC65234, HHSN268201300002I/N01HC65235,
   HHSN268201300003I/N01-HC-65236, HHSN268201300005I/N01HC65237]; National
   Institute on Minority Health and Health Disparities; National Institute
   on Deafness and Other Communication Disorders; National Institute of
   Dental and Craniofacial Research; National Institute of Diabetes and
   Digestive and Kidney Diseases; National Institute of Neurological
   Disorders and Stroke; NIH Office of Dietary Supplements
FX The authors thank the staff and participants of HCHS/SOL for their
   important contributions. A complete list of baseline staff and
   investigators has been provided by Sorlie et al [38] and is also
   available on the study website [87,88] . SGM SOL has been funded by the
   National Heart Blood and Lung Institute (R01HL149778) . HCHS/SOL is a
   collaborative study supported by contracts from the National Heart,
   Lung, and Blood Institute (NHLBI) to the University of North Carolina
   (HHSN268201300001I/N01HC65233) , University of Miami
   (HHSN268201300004I/N01HC65234) , Albert Einstein College of Medicine
   (HHSN268201300002I/N01HC65235) , University of Illinois at Chicago
   (HHSN268201300003I/N01-HC-65236 Northwestern Univ) , and San Diego State
   University (HHSN268201300005I/N01HC65237) . The following institutes,
   centers, and offices have contributed to HCHS/SOL through a transfer of
   funds to the NHLBI: National Institute on Minority Health and Health
   Disparities, National Institute on Deafness and Other Communication
   Disorders, National Institute of Dental and Craniofacial Research,
   National Institute of Diabetes and Digestive and Kidney Diseases,
   National Institute of Neurological Disorders and Stroke, and NIH Office
   of Dietary Supplements.
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NR 85
TC 7
Z9 8
U1 1
U2 10
PU JMIR PUBLICATIONS, INC
PI TORONTO
PA 130 QUEENS QUAY E, STE 1102, TORONTO, ON M5A 0P6, CANADA
SN 1929-0748
J9 JMIR RES PROTOC
JI JMIR RES. Protoc.
PD MAY
PY 2021
VL 10
IS 5
AR e28997
DI 10.2196/28997
PG 15
WC Health Care Sciences & Services; Public, Environmental & Occupational
   Health
WE Emerging Sources Citation Index (ESCI)
SC Health Care Sciences & Services; Public, Environmental & Occupational
   Health
GA SN4JJ
UT WOS:000658257400033
PM 33955843
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Roshanravan, N
   Ghaffari, S
AF Roshanravan, Neda
   Ghaffari, Samad
TI The therapeutic potential of Crocus sativus Linn.: A
   comprehensive narrative review of clinical trials
SO PHYTOTHERAPY RESEARCH
LA English
DT Review
DE anti-inflammatory; antioxidant; Crocus sativus Linn; saffron
ID PERSISTENT ALLERGIC-ASTHMA; MAJOR DEPRESSIVE DISORDER; DOUBLE-BLIND;
   SAFFRON SUPPLEMENTATION; METABOLIC SYNDROME; PREMENSTRUAL-SYNDROME;
   OXIDATIVE STRESS; TRIPLE-BLIND; L. SAFFRON; ANTIINFLAMMATORY PROPERTIES
AB Crocus sativus Linn. (Saffron) is valued worldwide for its potential use in the management of various degenerative disorders, including cardiovascular diseases (CVDs), diabetes, cancer, metabolic syndrome (MetS), neurodegenerative diseases, immune disorders, and sexual dysfunction. Previous reports, based on clinical trials, suggest that crocetin, crocin, picrocrocin, and safranal are the main bioactive components of saffron with antioxidant, anti-inflammatory, and anti-apoptotic effects. In this comprehensive narrative review, we studied the recent clinical trials, investigating the medicinal applications of saffron and/or its components. The present results can provide important insights into the potential of saffron in preventing and treating different disorders, with a special focus on the underlying cellular and molecular mechanisms. However, further high-quality studies are needed to firmly establish the clinical efficacy of saffron in treating some degenerative diseases.
C1 [Roshanravan, Neda; Ghaffari, Samad] Tabriz Univ Med Sci, Cardiovasc Res Ctr, Tabriz, Iran.
C3 Tabriz University of Medical Science
RP Roshanravan, N; Ghaffari, S (corresponding author), Tabriz Univ Med Sci, Cardiovasc Res Ctr, Tabriz, Iran.
EM neda.roshanravan10@gmail.com; ghafaris@gmail.com
OI Ghaffari, Samad/0000-0001-6806-9387
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NR 154
TC 20
Z9 20
U1 0
U2 30
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0951-418X
EI 1099-1573
J9 PHYTOTHER RES
JI Phytother. Res.
PD JAN
PY 2022
VL 36
IS 1
BP 98
EP 111
DI 10.1002/ptr.7286
EA SEP 2021
PG 14
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA YJ6VJ
UT WOS:000696498600001
PM 34532906
DA 2025-06-11
ER

PT J
AU Nishigaki, Y
   Fuku, N
   Tanaka, M
AF Nishigaki, Yutaka
   Fuku, Noriyuki
   Tanaka, Masashi
TI Mitochondrial haplogroups associated with lifestyle-related diseases and
   longevity in the Japanese population
SO GERIATRICS & GERONTOLOGY INTERNATIONAL
LA English
DT Review
DE haplogroup; lifestyle-related disease; longevity; mitochondrial genome;
   polymorphism
ID CYTOCHROME-B GENE; C-REACTIVE PROTEIN; SUPEROXIDE-PRODUCTION; METABOLIC
   SYNDROME; INSULIN-SECRETION; OXIDATIVE STRESS; DNA; RISK; POLYMORPHISMS;
   DYSFUNCTION
AB Recently published results on the association between metabolic syndrome, type 2 diabetes, myocardial infarction or atherothrombotic cerebral infarction and Japanese major haplogroups based on the comprehensive analysis of mitochondrial genome polymorphisms (mtSNP) in the coding region of human mitochondrial DNA (mtDNA), and longevity-related haplogroups are described in the present review. Our aim was to provide information that would allow us to predict the genetic risk for lifestyle-related diseases and thereby contribute to the primary prevention of these conditions. The mitochondrial genome variation is so large that a given haplogroup might consist of various subhaplogroups carrying unique and presumably functional mtSNP. The frequency of each subhaplogroup is sometimes only a few percent. Therefore, large-scale association study is necessary for elucidating the impact of each subhaplogroup on the susceptibility to various common diseases. Geriatr Gerontol Int 2010; 10 (Suppl. 1): S221-S235.
C1 [Nishigaki, Yutaka; Fuku, Noriyuki; Tanaka, Masashi] Tokyo Metropolitan Inst Gerontol, Dept Genom Longev & Hlth, Itabashi Ku, Tokyo 1730015, Japan.
C3 Tokyo Metropolitan Institute of Gerontology
RP Tanaka, M (corresponding author), Tokyo Metropolitan Inst Gerontol, Dept Genom Longev & Hlth, Itabashi Ku, 35-2 Sakae Cho, Tokyo 1730015, Japan.
EM mtanaka@tmig.or.jp
OI Fuku, Noriyuki/0000-0001-7792-5835
FU Japan Science and Technology Corporation; Ministry of Education,
   Culture, Sports, Science and Technology [C210832009, A [2]-15200051];
   Nervous and Mental Disorders of the Ministry of Health, Labour; Takeda
   Science Foundation; Scientific Research Sankyo Foundation of Life
   Science;  [18590317]; Grants-in-Aid for Scientific Research [21590411]
   Funding Source: KAKEN
FX This work was supported in part by the Support Project for Database
   Development from the Japan Science and Technology Corporation (to M.T.);
   a grant-in-aid (C210832009, A [2]-15200051 to M.T.) from the Ministry of
   Education, Culture, Sports, Science and Technology; by a grant from the
   Third-Term Comprehensive 10-year Strategy for Cancer Control (to M.T.);
   by grant 20B-13 from the program Research Grants for Nervous and Mental
   Disorders of the Ministry of Health, Labour, and Welfare (to M.T.); by a
   grant from the program Grants-in-Aid for (C) (18590317 to Y.N.); and by
   grants for scientific research from the Kao Research Council for the
   study of Healthcare Science (to Y.N.) and from the Takeda Science
   Foundation (to M.T. and to Y.N.) and Scientific Research Sankyo
   Foundation of Life Science (to Y.N.).
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NR 69
TC 23
Z9 26
U1 2
U2 8
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1444-1586
EI 1447-0594
J9 GERIATR GERONTOL INT
JI Geriatr. Gerontol. Int.
PD JUL
PY 2010
VL 10
SU 1
BP S221
EP S235
DI 10.1111/j.1447-0594.2010.00599.x
PG 15
WC Geriatrics & Gerontology; Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA 604WD
UT WOS:000278308300024
PM 20590837
DA 2025-06-11
ER

PT J
AU Tekin, HG
   Wu, JJ
   Burge, R
   Birt, J
   Egeberg, A
AF Tekin, Hasan G.
   Wu, Jashin J.
   Burge, Russel
   Birt, Julie
   Egeberg, Alexander
TI Burden and Disease Characteristics of Patients with Psoriatic Arthritis:
   A Population-based Cross-sectional Study
SO JOURNAL OF RHEUMATOLOGY
LA English
DT Article
DE PSORIATIC ARTHRITIS; PSORIASIS; DISEASE BURDEN; EPIDEMIOLOGY
ID METABOLIC SYNDROME; PREVALENCE; COMORBIDITIES; EPIDEMIOLOGY; REGISTER
AB Objective. To describe the prevalence and treatment regimes, disease characteristics, and comorbid diseases among patients with psoriatic arthritis (PsA) in Denmark.
   Methods. All Danish individuals aged >= 18 years with rheumatologist-diagnosed PsA were linked in nationwide administrative registers.
   Results. Among 4.7 million individuals in Denmark, 10,577 patients with PsA had been diagnosed by a rheumatologist. A female predominance (54.5-59.8%) was seen among patients with PsA, and about half of the patients (53.0%) had received no treatment or treatment only with nonsteroidal antiinflammatory drugs/systemic corticosteroids, while 32.9% had received nonbiological disease-modifying antirheumatic drugs (DMARD) and 14.1% had been treated with biologicals. Cutaneous psoriasis was recorded in 66.2-72.3% of patients with PsA, and patients with severe PsA had the highest prevalences of distal interphalangeal arthropathy, spondylitis, and arthritis mutilans. Smoking and comorbid diseases such as hypertension, diabetes, depression, and anxiety were seen frequently in patients with PsA, but did not significantly differ across severities of PsA.
   Conclusion. Disease burden appeared to be significant in patients with PsA across all severities. A considerable proportion of patients with PsA did not receive active antipsoriatic treatment, and about 1 out of 3 patients was not diagnosed with psoriasis. Cutaneous symptoms of psoriasis in patients with PsA might be either underreported or undertreated.
C1 [Tekin, Hasan G.; Egeberg, Alexander] Univ Copenhagen, Herlev & Gentofte Hosp, Dept Dermatol & Allergy, Hellerup, Denmark.
   [Wu, Jashin J.] Kaiser Permanente, Los Angeles Med Ctr, Dept Dermatol, Los Angeles, CA USA.
   [Burge, Russel; Birt, Julie] Eli Lilly & Co, Indianapolis, IN 46285 USA.
   [Burge, Russel] Univ Cincinnati, Div Pharmaceut Sci, Cincinnati, OH USA.
C3 University of Copenhagen; Kaiser Permanente; University of California
   System; University of California Los Angeles; University of California
   Los Angeles Medical Center; Eli Lilly; University System of Ohio;
   University of Cincinnati
RP Egeberg, A (corresponding author), Herlev & Gentofte Hosp, Dept Dermatol & Allergy, Kildegardsvej 28, DK-2900 Hellerup, Denmark.
EM alexander.egeberg@gmail.com
RI Egeberg, Alexander/AFO-3479-2022; Burge, Russel/AAI-2390-2021
OI Burge, Russel/0000-0001-7907-6400; Tekin, Hasan
   Gokcer/0000-0001-7187-7940; Egeberg, Alexander/0000-0001-8257-1816; Wu,
   Jashin/0000-0002-1722-1892
FU Eli Lilly and Co.; Pfizer; Eli Lilly; Danish National Psoriasis
   Foundation; Kgl Hofbundtmager Aage Bang Foundation
FX This study was funded by Eli Lilly and Co. The funding source
   participated in interpretation of the final analyzed study results, but
   had no access to the raw data, and did not participate in data
   collection, management, or analysis. Dr. Wu is an investigator for
   AbbVie, Amgen, Eli Lilly, Janssen, Novartis, and Regeneron. Dr. Burge
   and J. Birt are currently employed by Eli Lilly and Co. Dr. Egeberg has
   received research funding from Pfizer, Eli Lilly, the Danish National
   Psoriasis Foundation, and the Kgl Hofbundtmager Aage Bang Foundation,
   and honoraria as a consultant and/or speaker from Leo Pharma, Samsung
   Bioepis Co. Ltd., Pfizer, Eli Lilly, Novartis, Galderma, and Janssen
   Pharmaceuticals.
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NR 22
TC 11
Z9 11
U1 0
U2 0
PU J RHEUMATOL PUBL CO
PI TORONTO
PA 365 BLOOR ST E, STE 901, TORONTO, ONTARIO M4W 3L4, CANADA
SN 0315-162X
EI 1499-2752
J9 J RHEUMATOL
JI J. Rheumatol.
PD JUL 1
PY 2019
VL 46
IS 7
BP 716
EP 720
DI 10.3899/jrheum.180670
PG 5
WC Rheumatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Rheumatology
GA IJ3YJ
UT WOS:000475840400011
PM 30824662
OA Bronze
DA 2025-06-11
ER

PT J
AU Seino, S
   Tanaka, Y
   Honma, T
   Yanaka, M
   Sato, K
   Shinohara, N
   Ito, J
   Tsuduki, T
   Nakagawa, K
   Miyazawa, T
   Ikeda, I
AF Seino, Satoshi
   Tanaka, Yurie
   Honma, Taro
   Yanaka, Miyuki
   Sato, Kenta
   Shinohara, Nahoko
   Ito, Junya
   Tsuduki, Tsuyoshi
   Nakagawa, Kiyotaka
   Miyazawa, Teruo
   Ikeda, Ikuo
TI Atopic dermatitis causes lipid accumulation in the liver of NC/Nga mouse
SO JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION
LA English
DT Article
DE allergy; DNA microarray; lipid metabolism; liver; NC/Nga
ID CONJUGATED TRIENE SYSTEM; ALPHA-ELEOSTEARIC-ACID; METABOLIC SYNDROME;
   OXIDATIVE STRESS; FOOD-INTAKE; TNF-ALPHA; OBESITY; P53; DISEASE;
   APOPTOSIS
AB Various factors have been reported to influence lipid metabolism and cause metabolic syndrome. However, the influence of allergy on the liver that plays important role of lipid metabolism has not been clarified. The aim of this study was to examine the influence of allergy on lipid metabolism of liver. A model of atopic dermatitis was developed in the NC/Nga mouse using picryl chloride to induce allergy. Lipid metabolism parameters were measured and the mechanism of changes in these parameters was examined using DNA microarray analysis and quantitative reverse transcriptase PCR. Triacylglycerol accumulation was promoted in the liver in the mouse atopic dermatitis model despite reductions in food intake, body weight gain, and serum glucose. As this mechanism, it was thought that atopic dermatitis caused the suppression of fatty acid beta-oxidation. These results suggest that atopic dermatitis causes lipid accumulation in the liver.
C1 [Seino, Satoshi; Tanaka, Yurie; Honma, Taro; Yanaka, Miyuki; Sato, Kenta; Shinohara, Nahoko; Ito, Junya; Tsuduki, Tsuyoshi; Ikeda, Ikuo] Tohoku Univ, Grad Sch Agr, Lab Food & Biomol Sci, Sendai, Miyagi 9818555, Japan.
   [Nakagawa, Kiyotaka; Miyazawa, Teruo] Tohoku Univ, Grad Sch Agr, Food & Biodynam Chem Lab, Sendai, Miyagi 9818555, Japan.
C3 Tohoku University; Tohoku University
RP Tsuduki, T (corresponding author), Tohoku Univ, Grad Sch Agr, Lab Food & Biomol Sci, Sendai, Miyagi 9818555, Japan.
EM tsuzukit@biochem.tohoku.ac.jp
RI Ito, Junya/KPA-7635-2024; Tsuduki, Tsuyoshi/T-2697-2019
OI Tsuduki, Tsuyoshi/0000-0001-7810-0528; Ito, Junya/0000-0001-9190-4969
FU Uehara Memorial Foundation, Japan; Grants-in-Aid for Scientific Research
   [20228002] Funding Source: KAKEN
FX This study was supported from The Uehara Memorial Foundation, Japan.
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NR 49
TC 24
Z9 26
U1 1
U2 14
PU JOURNAL CLINICAL BIOCHEMISTRY & NUTRITION
PI KYOTO
PA KYOTO PREFECTURAL UNIV MED, GRAD SCH MEDICAL SCIENCE, DEPT MOLECULAR
   GASTROENTEROLOGY & HEPATOLOGY, KYOTO, 602-8566, JAPAN
SN 0912-0009
EI 1880-5086
J9 J CLIN BIOCHEM NUTR
JI J. Clin. Biochem. Nutr.
PD MAR 1
PY 2012
VL 50
IS 2
BP 152
EP 157
DI 10.3164/jcbn.11-29
PG 6
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 922DB
UT WOS:000302525900009
PM 22448097
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Seligowski, AV
   Webber, TK
   Marvar, PJ
   Ressler, KJ
   Philip, NS
AF Seligowski, Antonia, V
   Webber, Theresa K.
   Marvar, Paul J.
   Ressler, Kerry J.
   Philip, Noah S.
TI Involvement of the brain-heart axis in the link between PTSD and
   cardiovascular disease
SO DEPRESSION AND ANXIETY
LA English
DT Review
DE autonomic; brain-heart axis; cardiovascular disease; inflammation; PTSD;
   sex
ID POSTTRAUMATIC-STRESS-DISORDER; TRANSCRANIAL MAGNETIC STIMULATION;
   ANGIOTENSIN-ALDOSTERONE-SYSTEM; RATE-VARIABILITY; BLOOD-PRESSURE; MAJOR
   DEPRESSION; SEX-DIFFERENCES; ENDOTHELIAL FUNCTION; PROLONGED EXPOSURE;
   METABOLIC SYNDROME
AB Posttraumatic stress disorder (PTSD) has long been associated with a heightened risk of cardiovascular disease (CVD). A number of mechanisms have been implicated to underlie this brain-heart axis relationship, such as altered functioning of the autonomic nervous system and increased systemic inflammation. While neural alterations have repeatedly been observed in PTSD, they are rarely considered in the PTSD-CVD link. The brain-heart axis is a pathway connecting frontal and limbic brain regions to the brainstem and periphery via the autonomic nervous system and it may be a promising model for understanding CVD risk in PTSD given its overlap with PTSD neural deficits. We first provide a summary of the primary mechanisms implicated in the association between PTSD and CVD. We then review the brain-heart axis and its relevance to PTSD, as well as findings from PTSD trials demonstrating that a number of PTSD treatments have effects on areas of the brain-heart axis. Finally, we discuss sex considerations in the PTSD-CVD link. A critical next step in this study is to determine if PTSD treatments that affect the brain-heart axis (e.g., brain stimulation that improves autonomic function) also reduce the risk of CVD.
C1 [Seligowski, Antonia, V; Ressler, Kerry J.] Harvard Med Sch, Dept Psychiat, Boston, MA USA.
   [Seligowski, Antonia, V; Webber, Theresa K.; Ressler, Kerry J.] McLean Hosp, Div Depress & Anxiety Disorders, Belmont, MA 02178 USA.
   [Marvar, Paul J.] George Washington Univ, Dept Pharmacol & Physiol, Washington, DC USA.
   [Philip, Noah S.] Providence VA Med Ctr, VA RR&D Ctr Neurorestorat & Neurotechnol, Providence, RI USA.
   [Philip, Noah S.] Brown Univ, Dept Psychiat & Human Behav, Alpert Med Sch, Providence, RI 02912 USA.
C3 Harvard University; Harvard Medical School; Harvard University; Harvard
   University Medical Affiliates; McLean Hospital; George Washington
   University; US Department of Veterans Affairs; Veterans Health
   Administration (VHA); Providence VA Medical Center; Brown University
RP Seligowski, AV (corresponding author), 115 Mill St,Mail Stop 212, Belmont, MA 02478 USA.
EM aseligowski@mclean.harvard.edu
RI Philip, Ninan/AAQ-4553-2020; Seligowski, Antonia/GLV-3861-2022; Ressler,
   Kerry/N-8741-2018; Philip, Noah/C-3714-2016
OI Philip, Noah/0000-0002-4889-8775
FU American Heart Association; National Institutes of Health; National
   Institute of Mental Health [P50MH115874] Funding Source: NIH RePORTER
FX American Heart Association; National Institutes of Health
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NR 156
TC 26
Z9 30
U1 3
U2 21
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1091-4269
EI 1520-6394
J9 DEPRESS ANXIETY
JI Depress. Anxiety
PD OCT
PY 2022
VL 39
IS 10-11
BP 663
EP 674
DI 10.1002/da.23271
EA JUN 2022
PG 12
WC Psychology, Clinical; Psychiatry; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA 5F5NE
UT WOS:000811597600001
PM 35708302
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Balaji, MP
   Rajeswari, D
AF Balaji, Menaka Priya
   Rajeswari V, Devi
TI Endothelial Dysfunction associated with Diabetes Mellitus linked to
   extracellular signal-regulated kinase and inflammatory pathways
SO RESEARCH JOURNAL OF BIOTECHNOLOGY
LA English
DT Review
DE Endothelial dysfunction; Atherogenesis; Metabolic syndrome; Markers;
   Inflammation
ID GROWTH-FACTOR; RECEPTOR INHIBITION; OXIDATIVE STRESS; RISK-FACTORS;
   ATHEROSCLEROSIS; CHOLESTEROL; GENERATION; CORONARY; OBESITY
AB Endothelial dysfunction and core illnesses are now among the top causes of death on a global scale. Atherogenesis is a prominent risk factor for adverse vascular blockage diseases. People who have hyperglycemia and hyperlipidemia become more prone to developing cerebro-cardiovascular disease and lower limb disorders. Additionally, diabetic metabolic syndrome additionally alters the extracellular signalregulated kinase and immunosignal pathways, as well as the activation of vascular endothelial growth factor, nuclear factors and cell migration all of which contribute to pathogenesis.
   The creation of fibrous and fatty lesions in the intimal layer of an artery is referred to as atherogenesis associated vascular problems. In this study, atherogenic lipid particles, markers and inflammatory signaling pathways related to hyperglycemia and hyperlipidemia complications of atherosclerosis are discussed which will aid in the development of a new strategy to treat the macro-vascular complication for future research and treatment.
C1 [Balaji, Menaka Priya; Rajeswari V, Devi] VIT, Dept Biomed Sci, Sch Biosci & Technol, Vellore 632114, Tamil Nadu, India.
C3 Vellore Institute of Technology (VIT); VIT Vellore
RP Rajeswari, D (corresponding author), VIT, Dept Biomed Sci, Sch Biosci & Technol, Vellore 632114, Tamil Nadu, India.
EM vdevirajeswari@vit.ac.in
RI RAJESWARI, DEVI/T-3738-2019
OI BALAJI, MENAKA PRIYA/0000-0002-0494-6579
CR Abou-Jaoude A.
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   Zirnheld Arin Lee, 2013
NR 81
TC 2
Z9 2
U1 0
U2 0
PU RESEARCH JOURNAL BIOTECHNOLOGY
PI INDORE
PA SECTOR A-80, SCHEME NO 54, VIJAY NAGAR, A B ROAD, INDORE, 452 010 MP,
   INDIA
SN 2278-4535
J9 RES J BIOTECHNOL
JI Res. J. Biotechnol.
PD JAN
PY 2023
VL 18
IS 1
BP 135
EP 146
PG 12
WC Biotechnology & Applied Microbiology
WE Emerging Sources Citation Index (ESCI)
SC Biotechnology & Applied Microbiology
GA 7B2CA
UT WOS:000898947000018
DA 2025-06-11
ER

PT J
AU Schinzari, F
   Tesauro, M
   Rovella, V
   Di Daniele, N
   Gentileschi, P
   Mores, N
   Campia, U
   Cardillo, C
AF Schinzari, Francesca
   Tesauro, Manfredi
   Rovella, Valentina
   Di Daniele, Nicola
   Gentileschi, Paolo
   Mores, Nadia
   Campia, Umberto
   Cardillo, Carmine
TI Rho-kinase inhibition improves vasodilator responsiveness during
   hyperinsulinemia in the metabolic syndrome
SO AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
LA English
DT Article
DE fasudil; endothelium-dependent dilation; endothelium-ndependent
   dilation; insulin; obesity
ID SMOOTH-MUSCLE-CELLS; INSULIN-RESISTANCE; NITRIC-OXIDE; IN-VIVO;
   ENDOTHELIAL DYSFUNCTION; SIGNALING PATHWAYS; HUMANS; ACTIVATION;
   PHOSPHATASE; PREVENTS
AB Schinzari F, Tesauro M, Rovella V, Di Daniele N, Gentileschi P, Mores N, Campia U, Cardillo C. Rho-kinase inhibition improves vasodilator responsiveness during hyperinsulinemia in the metabolic syndrome. Am J Physiol Endocrinol Metab 303: E806-E811, 2012. First published July 24, 2012; doi:10.1152/ajpendo.00206.2012.-In patients with the metabolic syndrome (MetS), the facilitatory effect of insulin on forearm vasodilator responsiveness to different stimuli is impaired. Whether the RhoA/Rho kinase (ROCK) pathway is involved in this abnormality is unknown. We tested the hypotheses that, in MetS patients, ROCK inhibition with fasudil restores insulin-stimulated vasodilator reactivity and that oxidative stress plays a role in this mechanism. Endothelium-dependent and -independent forearm blood flow responses to acetylcholine (ACh) and sodium nitroprusside (SNP), respectively, were assessed in MetS patients (n = 8) and healthy controls (n = 5) before and after the addition of fasudil (200 mu g/min) to an intra- arterial infusion of insulin (0.1 mU/kg/min). In MetS patients (n = 5), fasudil was also infused without hyperinsulinemia. The possible involvement of oxidative stress in the effect of fasudil during hyperinsulinemia was investigated in MetS patients (n = 5) by infusing vitamin C (25 mg/min). In MetS patients, compared with saline, fasudil enhanced endothelium-dependent and - independent vasodilator responses during insulin infusion (P < 0.001 and P = 0.008, respectively), but not in the absence of hyperinsulinemia (P = 0.25 and P = 0.13, respectively). By contrast, fasudil did not affect vasoreactivity to ACh and SNP during hyperinsulinemia in controls (P = 0.11 and P = 0.56, respectively). In MetS patients, fasudil added to insulin and vitamin C did not further enhance vasodilation to ACh and SNP (P = 0.15 and P = 0.43, respectively). In the forearm circulation of patients with the MetS, ROCK inhibition by fasudil improves endothelium-dependent and - independent vasodilator responsiveness during hyperinsulinemia; increased oxidative stress seems to be involved in the pathophysiology of this phenomenon.
C1 [Schinzari, Francesca; Cardillo, Carmine] Catholic Univ Med Sch, Dept Internal Med, Rome, Italy.
   [Campia, Umberto] Catholic Univ Med Sch, Dept Pharmacol, Rome, Italy.
   [Tesauro, Manfredi; Rovella, Valentina; Di Daniele, Nicola] Univ Roma Tor Vergata, Dept Internal Med, Rome, Italy.
   [Gentileschi, Paolo] Univ Roma Tor Vergata, Dept Surg, Rome, Italy.
   [Campia, Umberto] Northwestern Univ, Div Cardiol, Feinberg Sch Med, Chicago, IL 60611 USA.
C3 Catholic University of the Sacred Heart; Catholic University of the
   Sacred Heart; University of Rome Tor Vergata; University of Rome Tor
   Vergata; Northwestern University; Feinberg School of Medicine
RP Cardillo, C (corresponding author), Univ Cattolica Sacro Cuore, Ist Patol Speciale Med & Semeiot Med, Largo Gemelli 8, I-00168 Rome, Italy.
EM carmine.cardillo@rm.unicatt.it
RI Rovella, Valentina/AAB-9727-2019; schinzari, francesca/AAB-9982-2019
OI Gentileschi, Paolo/0009-0007-3068-9848; MORES,
   Nadia/0000-0002-4197-0914; Cardillo, Carmine/0000-0001-5182-3005;
   Rovella, Valentina/0000-0002-3311-486X
FU Fondi d'Ateneo grants from the Universita Cattolica del Sacro Cuore;
   Fondazione Roma grant; National Heart, Lung, and Blood Institute grant
   [K12-HL-083790]
FX This work was partially supported by Fondi d'Ateneo grants from the
   Universita Cattolica del Sacro Cuore to C. Cardillo and by a Fondazione
   Roma grant to M. Tesauro. U. Campia is supported by a National Heart,
   Lung, and Blood Institute grant (K12-HL-083790).
CR Beckman JA, 2001, CIRCULATION, V103, P1618, DOI 10.1161/01.CIR.103.12.1618
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NR 31
TC 15
Z9 17
U1 0
U2 2
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0193-1849
EI 1522-1555
J9 AM J PHYSIOL-ENDOC M
JI Am. J. Physiol.-Endocrinol. Metab.
PD SEP
PY 2012
VL 303
IS 6
BP E806
EP E811
DI 10.1152/ajpendo.00206.2012
PG 6
WC Endocrinology & Metabolism; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Physiology
GA 009BB
UT WOS:000308999200012
PM 22829585
OA Green Published
DA 2025-06-11
ER

PT J
AU Nadalin, S
   Pavlic, SD
   Peitl, V
   Karlovic, D
   Zatkovic, L
   Ristic, S
   Buretic-Tomljanovic, A
   Jakovac, H
AF Nadalin, Sergej
   Pavlic, Sanja Devic
   Peitl, Vjekoslav
   Karlovic, Dalibor
   Zatkovic, Lena
   Ristic, Smiljana
   Buretic-Tomljanovic, Alena
   Jakovac, Hrvoje
TI Association between Insertion-Deletion Polymorphism of the
   Angiotensin-Converting Enzyme Gene and Treatment Response to
   Antipsychotic Medications: A Study of Antipsychotic-Naive First-Episode
   Psychosis Patients and Nonadherent Chronic Psychosis Patients
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE angiotensin-converting enzyme (ACE); antipsychotic medication;
   polymorphism; insertion; deletion; treatment response
ID NEGATIVE-SYNDROME-SCALE; CEREBROSPINAL-FLUID; METABOLIC SYNDROME;
   REPLACEMENT THERAPY; I/D POLYMORPHISM; 5-FACTOR MODEL; KININASE-II;
   SCHIZOPHRENIA; SUSCEPTIBILITY; VALIDATION
AB We investigated whether a functional insertion/deletion (I/D) polymorphism of angiotensin-converting enzyme (ACE) influenced antipsychotic treatment. At baseline, and after 8 weeks of treatment with various antipsychotic medications, we assessed patients' Positive and Negative Syndrome Scale (PANSS) scores, PANSS factors, and metabolic-syndrome-related parameters (fasting plasma lipid and glucose levels, and body mass index). A total of 186 antipsychotic-naive first-episode psychosis patients or nonadherent chronic psychosis individuals (99 males and 87 females) were genotyped by polymerase chain reaction analysis. The ACE-I/D polymorphism was significantly associated with changes in PANSS psychopathology only (p < 0.05). Compared to ACE-II homozygous males, ACE-DD homozygous and ACE-ID heterozygous males manifested significantly greater decreases in PANSS positive score, PANSS excitement factor, and PANSS cognitive factor. ACE-DD homozygous females manifested higher decreases in PANSS depression factor compared to ACE-II homozygous and ACE-ID heterozygous females. The polymorphism's effect size was estimated as moderate to strong, while its contribution to the PANSS psychopathology ranged from similar to 5.4 to 8.7%, with the lowest contribution observed for PANSS positive score changes and the highest for PANSS depressive factor changes. Our results indicate that ACE-I/D polymorphism had a statistically significant but weak gender-specific impact on psychopathology data, and showed no association between ACE-I/D polymorphism and metabolic-syndrome-related parameters.
C1 [Nadalin, Sergej] Gen Hosp Dr Josip Ben Evi, Dept Psychiat, Slavonski Brod 35000, Croatia.
   [Nadalin, Sergej; Peitl, Vjekoslav; Karlovic, Dalibor] Catholic Univ Croatia, Sch Med, Zagreb 10000, Croatia.
   [Pavlic, Sanja Devic; Ristic, Smiljana; Buretic-Tomljanovic, Alena] Univ Rijeka, Fac Med, Dept Med Biol & Genet, Rijeka 51000, Croatia.
   [Peitl, Vjekoslav; Karlovic, Dalibor] Sestre Milosrdnice Univ Hosp Ctr, Dept Psychiat, Zagreb 10000, Croatia.
   [Zatkovic, Lena] Hosp Pharm, Clin Hosp Ctr Rijeka, Rijeka 51000, Croatia.
   [Jakovac, Hrvoje] Univ Rijeka, Fac Med, Dept Physiol Immunol & Pathophysiol, Rijeka 51000, Croatia.
C3 University of Rijeka; University of Zagreb; University of Rijeka;
   University of Rijeka
RP Jakovac, H (corresponding author), Univ Rijeka, Fac Med, Dept Physiol Immunol & Pathophysiol, Rijeka 51000, Croatia.
EM hrvoje.jakovac@medri.uniri.hr
RI Buretic-Tomljanovic, Alena/S-3985-2018; Ristić, Smiljana/R-5713-2018;
   Nadalin, Sergej/R-6189-2018; Jakovac, Hrvoje/P-6514-2018; Peitl,
   Vjekoslav/Q-9358-2018; Devic Pavlic, Sanja/Q-7922-2018
OI Peitl, Vjekoslav/0000-0003-4163-6411; Devic Pavlic,
   Sanja/0000-0001-8440-1722
FU University of Rijeka, Croatia [17.07.2.1.10, uniri-biomed-18-251,
   uniri-biomed-18-187]
FX This research was supported by grants 17.07.2.1.10, uniri-biomed-18-251,
   and uniri-biomed-18-187 from the University of Rijeka, Croatia. The
   University had no further role in the study design; data collection,
   analysis, or interpretation; or the decision to submit this paper for
   publication.
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NR 53
TC 3
Z9 3
U1 0
U2 3
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD OCT
PY 2022
VL 23
IS 20
AR 12180
DI 10.3390/ijms232012180
PG 11
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 5P0VK
UT WOS:000872879100001
PM 36293037
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Graybeal, AJ
   Brandner, CF
   Henderson, A
   Aultman, RA
   Vallecillo-Bustos, A
   Newsome, TA
   Stanfield, D
   Stavres, J
AF Graybeal, Austin J.
   Brandner, Caleb F.
   Henderson, Alex
   Aultman, Ryan A.
   Vallecillo-Bustos, Anabelle
   Newsome, Ta'Quoris A.
   Stanfield, Diavion
   Stavres, Jon
TI Associations between eating behaviors and metabolic syndrome severity in
   young adults
SO EATING BEHAVIORS
LA English
DT Article
DE Behavioral interventions; Emotional eating; Obesity; Metabolic syndrome;
   Health disparities; Eating disorders
ID CARDIOVASCULAR RISK; ENERGY-INTAKE; PREVALENCE; DEPRESSION; STATE; MASS;
   BMI
AB Metabolic syndrome (MetS), a precursor to cardiovascular disease and type II diabetes, is rapidly increasing in young adults. Accordingly, earlier interventions aimed at combating the onset of MetS in young adults are required. However, current behavioral interventions have failed to consider the eating behaviors that precede disease development, likely contributing to the consistently high failure rates of these interventions. The purpose of this cross-sectional study was to evaluate the associations between eating behaviors and MetS severity (MetSindex) in a sample of young adults. A sample of 104 (non-Hispanic White: 45; non-Hispanic Black: 49; Hispanic White: 5; Asian: 5) young adult (age: 23.1 +/- 4.4) males and females (F:61, M:43) completed anthropometric, blood pressure, blood glucose, and blood lipid assessments; each of which were used to calculate a continuous MetSindex score. Participants also completed the revised version of the 18-item Three-factor Eating Questionnaire to measure emotional eating (EmE), uncontrolled eating (UE), and cognitive restraint (CR). EmE was positively associated with MetSindex for young adult females (p = 0.033) and non-Hispanic Black participants (p = 0.050), but not male (p = 0.506) or non-Hispanic White participants (p = 0.558). Additionally, MetSindex was greater in the highest EmE tertile compared to the lowest EmE tertile for the total sample (p = 0.037) and young adult females (p = 0.015). UE and CR were not associated with MetSindex. These data suggest a potential link between EmE and MetS severity in young adults, and that behavioral interventions aimed at MetS prevention should focus on treating the underlying EmE behaviors common in young adults, particularly for young female and Black adults at the greatest risk.
C1 [Graybeal, Austin J.; Brandner, Caleb F.; Henderson, Alex; Aultman, Ryan A.; Vallecillo-Bustos, Anabelle; Newsome, Ta'Quoris A.; Stanfield, Diavion; Stavres, Jon] Univ Southern Mississippi, Sch Kinesiol & Nutr, Hattiesburg, MS 39406 USA.
   [Graybeal, Austin J.] Univ Southern Mississippi, Coll Educ & Human Sci, Sch Kinesiol & Nutr, Hattiesburg, MS 39406 USA.
C3 University of Southern Mississippi; University of Southern Mississippi
RP Graybeal, AJ (corresponding author), Univ Southern Mississippi, Coll Educ & Human Sci, Sch Kinesiol & Nutr, Hattiesburg, MS 39406 USA.
EM austin.graybeal@usm.edu
RI Stavres, Jon/JTS-7791-2023; Graybeal, Austin/AAO-5501-2021
OI Graybeal, Austin/0000-0003-4520-9230
FU University of Southern Mississippi
FX Funding was provided by the University of Southern Mississippi start-up
   funds for AJG and JS. There are no other funding sources report.
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NR 43
TC 8
Z9 8
U1 1
U2 3
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1471-0153
EI 1873-7358
J9 EAT BEHAV
JI Eat. Behav.
PD DEC
PY 2023
VL 51
AR 101821
DI 10.1016/j.eatbeh.2023.101821
EA OCT 2023
PG 6
WC Psychology, Clinical; Psychiatry
WE Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA X1SW4
UT WOS:001096327500001
PM 37866123
DA 2025-06-11
ER

PT J
AU Simjanoski, M
   Patel, S
   De Boni, R
   Balanzá-Martínez, V
   Frey, BN
   Minuzzi, L
   Kapczinski, F
   Cardoso, TD
AF Simjanoski, Mario
   Patel, Swara
   De Boni, Raquel
   Balanza-Martinez, Vicent
   Frey, Benicio N.
   Minuzzi, Luciano
   Kapczinski, Flavio
   Cardoso, Taiane de Azevedo
TI Lifestyle interventions for bipolar disorders: A systematic review and
   meta-analysis
SO NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
LA English
DT Review
DE Bipolar disorder; Lifestyle interventions; Systematic review;
   Meta-analysis; RCT; Lifestyle psychiatry; Lifestyle medicine; Diet;
   Exercise; Substance use; Stress; Sleep; Social relationships
ID QUALITY-OF-LIFE; SLEEP DISTURBANCE; METABOLIC SYNDROME; SOCIAL SUPPORT;
   EXERCISE; PSYCHOEDUCATION; DEPRESSION; RISK; NUTRITION; SYMPTOMS
AB This review and meta-analysis aimed to describe the existing literature on interventions for bipolar disorder (BD) targeting the 6 pillars of Lifestyle Psychiatry: diet, physical activity (PA), substance use (SU), sleep, stress management, and social relationships (SR). Randomized Controlled Trials that examined the efficacy of lifestyle interventions targeting improvement in depressive/(hypo)manic symptom severity, lifestyle patterns, func-tioning, quality of life, and/or circadian rhythms were included. The systematic review included 18 studies, while the meta-analysis included studies targeting the same lifestyle domains and outcomes. Sleep (n = 10), PA (n = 9), and diet (n = 8) were the most targeted domains, while SU, SM and SR were least targeted (n = 4 each). Combined diet and PA interventions led to significant improvements in depressive symptoms (SMD:-0.46; 95% CI:-0.88,-0.04; p = 0.03), and functioning (SMD:-0.47; 95%CI:-0.89,-0.05; p = 0.03). Sleep interventions also led to significant improvements in depressive symptoms (SMD:-0.80; 95%CI:-1.21,-0.39; p < 0.01). Future research should focus on developing more multidimensional lifestyle interventions for a potentially greater impact on clinical and functional outcomes of BD.
C1 [Simjanoski, Mario; Frey, Benicio N.; Minuzzi, Luciano; Kapczinski, Flavio] McMaster Univ, Neurosci Grad Program, 1280 Main St West, Hamilton, ON, Canada.
   [Simjanoski, Mario; Frey, Benicio N.; Minuzzi, Luciano; Kapczinski, Flavio; Cardoso, Taiane de Azevedo] McMaster Univ, Dept Psychiat & Behav Neurosci, 1280 Main St West, Hamilton, ON, Canada.
   [Patel, Swara; Cardoso, Taiane de Azevedo] McMaster Univ, Sch Interdisciplinary Sci, Life Sci Program, 1280 Main St West, Hamilton, ON, Canada.
   [De Boni, Raquel] Oswaldo Cruz Fdn FIOCRUZ, Inst Sci & Technol Commun & Informat Hlth ICICT, 4365 Manguinhos, Rio De Janeiro, Brazil.
   [Balanza-Martinez, Vicent; Minuzzi, Luciano] Univ Valencia, CIBERSAM, Dept Med, Teaching Unit Psychiat & Psychol Med, Av Blasco Ibanez 13, Valencia, Spain.
   [Frey, Benicio N.] St Josephs Healthcare, Womens Hlth Concerns Clin, 100 West 5th St, Hamilton, ON, Canada.
   [Frey, Benicio N.] St Josephs Healthcare, Mood Disorders Program, 100 West 5th St, Hamilton, ON, Canada.
   [Kapczinski, Flavio] Inst Nacl Ciencia & Tecnol Translac Med INCT TM, Porto Alegre, Brazil.
C3 McMaster University; McMaster University; McMaster University; Fundacao
   Oswaldo Cruz; University of Valencia; CIBER - Centro de Investigacion
   Biomedica en Red; CIBERSAM
RP Simjanoski, M (corresponding author), McMaster Univ, Neurosci Grad Program, 1280 Main St West, Hamilton, ON, Canada.
EM simjanom@mcmaster.ca
RI Frey, Benicio/AAJ-8212-2021; Balanzá-Martínez, Vicent/C-3073-2011;
   Minuzzi, Luciano/ABH-3481-2020; Kapczinski, Flavio/D-3175-2013
OI Balanza-Martinez, Vicent/0000-0001-7772-7396; Simjanoski,
   Mario/0000-0002-3139-9734; Kapczinski, Flavio/0000-0001-8738-856X
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NR 62
TC 14
Z9 15
U1 4
U2 19
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0149-7634
EI 1873-7528
J9 NEUROSCI BIOBEHAV R
JI Neurosci. Biobehav. Rev.
PD SEP
PY 2023
VL 152
AR 105257
DI 10.1016/j.neubiorev.2023.105257
EA JUN 2023
PG 13
WC Behavioral Sciences; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Behavioral Sciences; Neurosciences & Neurology
GA L2ND4
UT WOS:001021668600001
PM 37263531
DA 2025-06-11
ER

PT J
AU Kajikawa, M
   Higashi, Y
AF Kajikawa, Masato
   Higashi, Yukihito
TI Obesity and Endothelial Function
SO BIOMEDICINES
LA English
DT Review
DE obesity; endothelial function; atherosclerosis; cardiovascular events
ID BODY-MASS INDEX; EPICARDIAL ADIPOSE-TISSUE; FLOW-MEDIATED VASODILATION;
   FATTY LIVER-DISEASE; MEDITERRANEAN DIET; BARIATRIC SURGERY;
   NITRIC-OXIDE; INSULIN-RESISTANCE; METABOLIC SYNDROME; RISK-FACTORS
AB Obesity is a major public health problem and is related to increasing rates of cardiovascular morbidity and mortality. Over 1.9 billion adults are overweight or obese worldwide and the prevalence of obesity is increasing. Obesity influences endothelial function through obesity-related complications such as hypertension, dyslipidemia, diabetes, metabolic syndrome, and obstructive sleep apnea syndrome. The excess fat accumulation in obesity causes adipocyte dysfunction and induces oxidative stress, insulin resistance, and inflammation leading to endothelial dysfunction. Several anthropometric indices and imaging modalities that are used to evaluate obesity have demonstrated an association between obesity and endothelial function. In the past few decades, there has been great focus on the mechanisms underlying endothelial dysfunction caused by obesity for the prevention and treatment of cardiovascular events. This review focuses on pathophysiological mechanisms of obesity-induced endothelial dysfunction and therapeutic targets of obesity.
C1 [Kajikawa, Masato; Higashi, Yukihito] Hiroshima Univ Hosp, Med Ctr Translat & Clin Res, Div Regenerat & Med, Minami Ku, 1-2-3 Kasumi, Hiroshima 7348551, Japan.
   [Higashi, Yukihito] Hiroshima Univ, Res Inst Radiat Biol & Med, Div Radiat Med Sci, Dept Regenerat Med,Minami Ku, 1-2-3 Kasumi, Hiroshima 7348551, Japan.
C3 Hiroshima University; Hiroshima University
RP Higashi, Y (corresponding author), Hiroshima Univ Hosp, Med Ctr Translat & Clin Res, Div Regenerat & Med, Minami Ku, 1-2-3 Kasumi, Hiroshima 7348551, Japan.; Higashi, Y (corresponding author), Hiroshima Univ, Res Inst Radiat Biol & Med, Div Radiat Med Sci, Dept Regenerat Med,Minami Ku, 1-2-3 Kasumi, Hiroshima 7348551, Japan.
EM m-kajikawa@hiroshima-u.ac.jp; yhigashi@hiroshima-u.ac.jp
OI Higashi, Yukihito/0000-0001-5813-3672
FU JSPS KAKENHI [18590815, 21590898, JP19K17599]; Takeda Science
   Foundation; Japanese Arteriosclerosis Prevention Fund; Grants-in-Aid for
   Scientific Research [23K24329, 22H03068] Funding Source: KAKEN
FX This work was supported by JSPS KAKENHI (Grant Number 18590815 and
   21590898 to Y.H. and JP19K17599 to M.K.), the Takeda Science Foundation
   (to M.K.), and a Grant in Aid of Japanese Arteriosclerosis Prevention
   Fund (to Y.H.).
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NR 186
TC 44
Z9 44
U1 0
U2 33
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2227-9059
J9 BIOMEDICINES
JI Biomedicines
PD JUL
PY 2022
VL 10
IS 7
AR 1745
DI 10.3390/biomedicines10071745
PG 19
WC Biochemistry & Molecular Biology; Medicine, Research & Experimental;
   Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Research & Experimental Medicine;
   Pharmacology & Pharmacy
GA 3G6UM
UT WOS:000831487100001
PM 35885049
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Ng, DS
AF Ng, Dominic S.
TI Diabetic Dyslipidemia: From Evolving Pathophysiological Insight to
   Emerging Therapeutic Targets
SO CANADIAN JOURNAL OF DIABETES
LA English
DT Review
DE cardiovascular diseases; cholesterol efflux; diabetes; dyslipidemia; ER
   stress; HDL; insulin resistance; triglycerides
ID HIGH-DENSITY-LIPOPROTEIN; CORONARY-HEART-DISEASE; TANGIER-DISEASE;
   LECITHIN/CHOLESTEROL ACYLTRANSFERASE; METABOLIC SYNDROME; APOLIPOPROTEIN
   AI; CHOLESTEROL; ATHEROSCLEROSIS; TRIGLYCERIDE; INHIBITION
AB Diabetic dyslipidemia is characterized by hepatic very low density lipoprotein (VLDL) and intestinal chylomicron overproduction, reduced high density lipoprotein cholesterol (HDL-C) level, increased propensity of small dense LDL (sdLDL) and increased postprandial lipemia. This dyslipidemic profile is also strongly linked to other features of the metabolic syndrome. Diabetic dyslipidemia is a well-recognized risk factor for atherosclerotic cardiovascular diseases. Currently, statins remain the first line therapy primarily through reducing the atherogenic LDL. Clinical trials on other lipid modifying agents were met with variable success in selective patient populations. Emerging new insights into the pathophysiology of lipid metabolism, in general, and diabetic dyslipidemia, in particular, have opened up potentially novel therapeutic strategies to further reduce the risk associated with diabetic dyslipidemia and insulin resistant state. (C) 2013 Canadian Diabetes Association
C1 Univ Toronto, St Michaels Hosp, Li Ka Shing Knowledge Inst, Keenan Res Ctr, Toronto, ON M5B 1W8, Canada.
C3 University of Toronto; Li Ka Shing Knowledge Institute; Saint Michaels
   Hospital Toronto
RP Ng, DS (corresponding author), Univ Toronto, St Michaels Hosp, Li Ka Shing Knowledge Inst, Keenan Res Ctr, Shuter Wing Room 3-041,30 Bond St, Toronto, ON M5B 1W8, Canada.
EM ngd@smh.ca
FU Canadian Institutes for Health Research (CIHR) [MOP275369]; CIHR
   China-Canada Joint Health Research Initiative grant; Heart and Stroke
   Foundation of Ontario [NA 6331]
FX This work was supported in part by an operating grant from the Canadian
   Institutes for Health Research (CIHR; MOP275369), a CIHR China-Canada
   Joint Health Research Initiative grant and a Grant-in-aid (NA 6331) by
   the Heart and Stroke Foundation of Ontario.
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NR 64
TC 29
Z9 30
U1 0
U2 9
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1499-2671
J9 CAN J DIABETES
JI Can. J. Diabetes
PD OCT
PY 2013
VL 37
IS 5
BP 319
EP 326
DI 10.1016/j.jcjd.2013.07.062
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA AL8WC
UT WOS:000339419400008
PM 24500559
DA 2025-06-11
ER

PT J
AU Aishwarya, J
   Bobby, Z
   Nair, PP
   Sunitha, VC
   Menon, V
   Thalapalliyil, K
AF Aishwarya, J.
   Bobby, Zachariah
   Nair, Pradeep P.
   Sunitha, V. C.
   Menon, Vikas
   Thalapalliyil, Kamila
TI Increased vascular risk factors, atherosclerosis, and psychological
   distress among Indian adults with refractory epilepsy in comparison to
   well-controlled epilepsy
SO EPILEPSY & BEHAVIOR
LA English
DT Article
DE Refractory epilepsy; Metabolic syndrome; Atherosclerosis; Psychological
   distress; Vascular risk factors
ID INTIMA-MEDIA THICKNESS; IDENTIFYING INSULIN-RESISTANCE; SUDDEN
   UNEXPECTED DEATH; LIPID TETRAD INDEX; ANTIEPILEPTIC DRUGS; METABOLIC
   SYNDROME; CARDIOVASCULAR RISK; YOUNG-ADULTS; ATHEROGENIC INDEX; VALPROIC
   ACID
AB Objective: Comparison of cardiovascular risk factors, atherosclerosis, and psychological distress among adults with refractory versus well-controlled epilepsy.Methods: The cross-sectional study consisted of two groups of 40 people each: Group I - People with well-controlled epilepsy, Group II - People with refractory epilepsy. Age-and gender-matched people of 20-50 years were recruited. People who were diabetic, smokers, hypertensive, alcoholic, pregnant, with infections, and lactating women were excluded from the study. Biochemical parameters, fasting glucose, lipid profile, fasting insulin, leptin, adiponectin, Lp[a], hsCRP, TyG INDEX, HOMA1-%S, HOMA1-IR, HOMA1-%B, QUICKI, FIRI, AIP, AC, CLTI, MLTI, CRI-I, CRI-II, and CIMT were estimated. Stress levels [PSS-10, GAD-7 & PHQ-9] were assessed based on the scoring system from the questionnaires.Results: The existence of metabolic syndrome, levels of triglycerides, TyG index, MDA, OSI, CIMT, AIP, and stress scores [PSS-10, GAD-7 & PHQ-9] were significantly higher in the refractory-epilepsy group in com-parison to the well-controlled group. There were associations between LDL-C and CIMT as well as between GAD-7 and CIMT among all the study subjects. There were no significant differences in the levels of glucose homeostasis parameters, hsCRP, leptin, adiponectin, and Lp[a] between the two groups. Based on the ROC analysis, MDA [AUC = 0.853] and GAD-7 [AUC = 0.900] are useful in the differential diagnosis of the study groups.Conclusion: People with refractory epilepsy had increased levels of vascular risk factors, atherosclerosis, and stress levels compared to people with well-controlled epilepsy. Suitable disease management and therapeutic approaches to address cardiovascular and psychological distress could be planned out among people with refractory epilepsy to improve their quality of life. & COPY; 2023 Elsevier Inc. All rights reserved.
C1 [Aishwarya, J.; Bobby, Zachariah; Thalapalliyil, Kamila] Jawaharlal Inst Postgrad Med Educ & Res JIPMER, Dept Biochem, Pondicherry, India.
   [Nair, Pradeep P.] Jawaharlal Inst Postgrad Med Educ & Res JIPMER, Dept Neurol, Pondicherry, India.
   [Sunitha, V. C.] Jawaharlal Inst Postgrad Med Educ & Res JIPMER, Dept Radiodiag, Pondicherry, India.
   [Menon, Vikas] Jawaharlal Inst Postgrad Med Educ & Res JIPMER, Dept Psychiat, Pondicherry, India.
   [Bobby, Zachariah] JIPMER, Pondicherry 605006, India.
C3 Jawaharlal Institute of Postgraduate Medical Education & Research;
   Jawaharlal Institute of Postgraduate Medical Education & Research;
   Jawaharlal Institute of Postgraduate Medical Education & Research;
   Jawaharlal Institute of Postgraduate Medical Education & Research;
   Jawaharlal Institute of Postgraduate Medical Education & Research
RP Bobby, Z (corresponding author), JIPMER, Pondicherry 605006, India.
EM zacbobby@yahoo.com
RI Nair, Pradeep/K-4401-2015; Menon, Vikas/F-3100-2012; J,
   Aishwarya/HIZ-5699-2022; Zachariah, Bobby/IUQ-0806-2023
OI Vellathussery Chakkalakkoombil, Sunitha/0000-0001-7161-0277; Menon,
   Vikas/0000-0001-8035-4658; J, Aishwarya/0000-0002-0282-6434
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NR 69
TC 1
Z9 1
U1 1
U2 4
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 1525-5050
EI 1525-5069
J9 EPILEPSY BEHAV
JI Epilepsy Behav.
PD AUG
PY 2023
VL 145
AR 109326
DI 10.1016/j.yebeh.2023.109326
EA JUN 2023
PG 9
WC Behavioral Sciences; Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Behavioral Sciences; Neurosciences & Neurology; Psychiatry
GA M4YA2
UT WOS:001030271900001
PM 37392602
DA 2025-06-11
ER

PT S
AU Jia, GH
   Aroor, AR
   Sowers, JR
AF Jia, Guanghong
   Aroor, Annayya R.
   Sowers, James R.
BE Osiewacz, HD
TI Estrogen and Mitochondria Function in Cardiorenal Metabolic Syndrome
SO MITOCHONDRION IN AGING AND DISEASE
SE Progress in Molecular Biology and Translational Science
LA English
DT Review; Book Chapter
ID INSULIN-RESISTANCE; OXIDATIVE STRESS; DIABETES-MELLITUS; RECEPTOR-ALPHA;
   ANGIOTENSIN-II; FEMALE MICE; BODY-FAT; DYSFUNCTION; OBESITY; BETA
AB The cardiorenal metabolic syndrome (CRS) consists of a constellation of cardiac, renal, and metabolic disorders including insulin resistance (IR), obesity, metabolic dyslipidemia, high-blood pressure, and evidence of early cardiac and renal disease. Mitochondria dysfunction often occurs in the CRS, and this dysfunction is promoted by excess reactive oxygen species, genetic factors, IR, aging, and altered mitochondrial biogenesis. Recently, it has been shown that there are important sex-related differences in mitochondria function and metabolic, cardiovascular, and renal components. Sex differences in the CRS have mainly been attributed to the estrogen's effects that are mainly mediated by estrogen receptor (ER) alpha, ER beta, and G-protein coupled receptor 30. In this review, we discuss the effects of estrogen on the mitochondrial function, insulin metabolic signaling, glucose transport, lipid metabolism, and inflammatory responses from liver, pancreatic beta cells, adipocytes, skeletal muscle, and cardiovascular tissue.
C1 [Jia, Guanghong; Aroor, Annayya R.; Sowers, James R.] Diabet Cardiovasc Ctr, Div Endocrinol Diabet & Metab, Columbia, MO 65211 USA.
   [Jia, Guanghong; Aroor, Annayya R.; Sowers, James R.] Harry S Truman Mem Vet Hosp, Columbia, MO 65201 USA.
   [Sowers, James R.] Dept Med Pharmacol & Physiol, Columbia, MO USA.
C3 University of Missouri System; University of Missouri Columbia; US
   Department of Veterans Affairs; Veterans Health Administration (VHA);
   Harry S. Truman Memorial Veterans' Hospital
RP Jia, GH (corresponding author), Diabet Cardiovasc Ctr, Div Endocrinol Diabet & Metab, Columbia, MO 65211 USA.
FU NHLBI NIH HHS [R01 HL107910, R01 HL073101, R01 HL73101] Funding Source:
   Medline
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NR 74
TC 27
Z9 34
U1 1
U2 11
PU ELSEVIER ACADEMIC PRESS INC
PI SAN DIEGO
PA 525 B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495 USA
SN 1877-1173
BN 978-0-12-394625-6
J9 PROG MOL BIOL TRANSL
JI Prog. Molec. Biol. Transl. Sci.
PY 2014
VL 127
BP 229
EP 249
DI 10.1016/B978-0-12-394625-6.00009-X
PG 21
WC Biochemistry & Molecular Biology
WE Book Citation Index – Science (BKCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA BB1YQ
UT WOS:000341461400009
PM 25149220
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Lalika, M
   Mccoy, CR
   Jones, C
   Bancos, I
   Cooper, LA
   Hayes, SN
   Johnson, MP
   Kullo, IJ
   Kumbamu, A
   Noseworthy, PA
   Patten, CA
   Singh, R
   Wi, CI
   Brewer, LC
AF Lalika, Mathias
   Mccoy, Carrie R.
   Jones, Clarence
   Bancos, Irina
   Cooper, Lisa A.
   Hayes, Sharonne N.
   Johnson, Matthew P.
   Kullo, Iftikhar J.
   Kumbamu, Ashok
   Noseworthy, Peter A.
   Patten, Christi A.
   Singh, Ravinder
   Wi, Chung-Il
   Brewer, LaPrincess C.
TI Rationale, design, and participant characteristics of the FAITH! Heart
   Health plus study: An exploration of the influence of the social
   determinants of health, stress, and structural racism on African
   American cardiovascular health
SO CONTEMPORARY CLINICAL TRIALS
LA English
DT Article
DE Cardiovascular health; Health promotion; Social determinants of health;
   Psychosocial factors; African Americans
ID RANDOMIZED PILOT TRIAL; SOCIOECONOMIC-STATUS; MENTAL-HEALTH;
   UNITED-STATES; OUTCOMES; DISCRIMINATION; ASSOCIATIONS; DISPARITIES;
   PREVALENCE; IMPACT
AB Background: African Americans (AAs) face cardiovascular health (CVH) disparities linked to systemic racism. The 2020 police killing of Mr. George Floyd in Minneapolis, Minnesota, alongside the COVID-19 pandemic, exacerbated adverse psychosocial factors affecting CVH outcomes among AAs. This manuscript describes the study protocol and participant characteristics in an ancillary study exploring the relationship between biopsychosocial factors and CVH among AAs. Methods: Using a community-based participatory approach, a mixed-methods ancillary study of 58 AA participants from an overarching randomized control trial (RCT) was conducted. Baseline RCT health assessments (November 2020) provided sociodemographic, medical, and clinical data. Subsequent health assessments (February -December 2022) measured sleep quality, psychosocial factors (e.g., high-effort coping), biomarkers (e.g., cortisol), and cardiovascular diagnostics (e.g., cardio-ankle vascular index). CVH was assessed using the American Heart Association Life's Simple 7 (LS7) (range 0 to 14, poor to ideal) and Life's Essential 8 (LE8) scores (range 0 to 100, low to high). Correlations between these scores will be examined. Focus group discussions via videoconferencing (March to April 2022) assessed psychosocial and structural barriers, along with the impact of COVID-19 and George Floyd's killing on daily life. Results: Participants were predominantly female (67%), with a mean age of 54.6 [11.9] years, high cardiometabolic risk (93% had overweight/obesity and 70% hypertension), and moderate LE8 scores (mean 57.4, SD 11.5). Conclusion: This study will enhance understanding of the associations between biopsychosocial factors and CVH among AAs in Minnesota. Findings may inform risk estimation, patient care, and healthcare policies to address CVD disparities in marginalized populations.
C1 [Bancos, Irina; Brewer, LaPrincess C.] Mayo Clin, Coll Med, Dept Cardiovasc Med, 200 First St SW, Rochester, MN 55905 USA.
   [Cooper, Lisa A.] Hue Man Partnership, 2400 Pk Ave, Minneapolis, MN 55404 USA.
   [Johnson, Matthew P.] Mayo Clin, Coll Med, Div Endocrinol Diabet Metab & Nutr, 200 First St SW, Rochester, MN 55905 USA.
   [Kumbamu, Ashok] Johns Hopkins Univ, Sch Med, Dept Med, 2024 E Monument St,Suite 2-500, Baltimore, MD 21205 USA.
   [Patten, Christi A.] Mayo Clin, Dept Quantitat Hlth Sci, 200 First St SW, Rochester, MN 55905 USA.
   [Singh, Ravinder] Mayo Clin, Robert D & Patricia E Kern Ctr Sci Hlth Care Deliv, 200 First St SW, Rochester, MN 55905 USA.
   [Patten, Christi A.; Wi, Chung-Il] Mayo Clin, Coll Med, Dept Psychiat & Psychol, 200 First St SW, Rochester, MN 55905 USA.
   [Singh, Ravinder; Brewer, LaPrincess C.] Mayo Clin, Dept Lab Med & Pathol, Div Clin Biochem & Immunol, 200 First St SW, Rochester, MN 55905 USA.
   [Wi, Chung-Il] Mayo Clin, Dept Pediat & Adolescent Med, 200 First St SW, Rochester, MN 55905 USA.
   [Brewer, LaPrincess C.] Mayo Clin, Ctr Hlth Equ & Community Engagement Res, 200 First St SW, Rochester, MN 55905 USA.
C3 Mayo Clinic; Mayo Clinic; Johns Hopkins University; Mayo Clinic; Mayo
   Clinic; Mayo Clinic; Mayo Clinic; Mayo Clinic; Mayo Clinic
RP Brewer, LC (corresponding author), Mayo Clin, Coll Med, Dept Cardiovasc Med, 200 First St SW, Rochester, MN 55905 USA.
EM Lalika.Mathias@mayo.edu; mccoy.carrie@mayo.edu; Bancos.Irina@mayo.edu;
   lisa.cooper@jhmi.edu; Hayes.Sharonne@mayo.edu;
   johnson.matthew5@mayo.edu; Kullo.Iftikhar@mayo.edu;
   Kumbamu.Ashok@mayo.edu; Noseworthy.Peter@mayo.edu;
   Patten.Christi@mayo.edu; Singh.Ravinder@mayo.edu;
   brewer.laprincess@mayo.edu
RI Bancos, Irina/J-6560-2019
FU National Center for Advancing Translational Sci-ences (NCATS)
   [TR000135]; Mayo Clinic Center for Health Equity and Community
   Engagement in Research; Mayo Clinic Chief Executive Office; American
   Heart As-sociation-Amos Medical Faculty Development Program
   [19AMFDP35040005]; American Heart Association Second Century
   Implementation Science Award; NCATS (CTSA) [23SCISA1144689];
   Bristol-Myers Squibb Foundation [KL2 TR002379]; Centers for Disease
   Control and Prevention (CDC) [CDC-DP18-1817]; NIH/NIMHD P50 Center for
   Chronic Disease Reduction and Equity Promotion Across Minnesota;
   Pro-gram [C2DREAM]; American Heart Association through the Research
   Supplement to Promote Diversity in Science [P50MD017342]; Mayo Clinic
   NIH T32 Training Program [23DIVSUP1067167];  [T32 HL07111]; American
   Heart Association (AHA) [23DIVSUP1067167] Funding Source: American Heart
   Association (AHA)
FX The research reported herein was supported by the National Institutes of
   Health (NIH)/National Institute on Minority Health and Health
   Disparities (NIMHD) (Grant No. 1 R21 MD013490-01), the Clinical and
   Translational Science Awards (CTSA) (Grant No. UL1TR000135) from the
   National Center for Advancing Translational Sciences (NCATS) to Mayo
   Clinic, the Mayo Clinic Center for Health Equity and Community
   Engagement in Research and the Mayo Clinic Chief Executive Office. Dr.
   Brewer was supported by the American Heart Association-Amos Medical
   Faculty Development Program (Grant No. 19AMFDP35040005), American Heart
   Association Second Century Implementation Science Award (Grant No.
   23SCISA1144689), NCATS (CTSA Grant No. KL2 TR002379), the Bristol-Myers
   Squibb Foundation and the Centers for Disease Control and Prevention
   (CDC, Grant No. CDC-DP18-1817) and the NIH/NIMHD P50 Center for Chronic
   Disease Reduction and Equity Promotion Across Minnesota (C2DREAM)
   Program (Grant No. P50MD017342) during the implementation of this work.
   Dr. Lalika received funding from the American Heart Association through
   the Research Supplement to Promote Diversity in Science (Grant No.
   23DIVSUP1067167), while Dr. McCoy was funded by the Mayo Clinic NIH T32
   Training Program (Grant No. T32 HL07111). Its contents are solely the
   responsibility of the authors and do not neces-sarily represent the
   official views of NCATS, NIH, or CDC. The funding bodies had no role in
   study design; in the collection, analysis, and interpretation of data;
   writing of the manuscript; and in the decision to submit the manuscript
   for publication.r TR000135) from the National Center for Advancing
   Translational Sci-ences (NCATS) to Mayo Clinic, the Mayo Clinic Center
   for Health Equity and Community Engagement in Research and the Mayo
   Clinic Chief Executive Office. Dr. Brewer was supported by the American
   Heart As-sociation-Amos Medical Faculty Development Program (Grant No.
   19AMFDP35040005) , American Heart Association Second Century
   Implementation Science Award (Grant No. 23SCISA1144689) , NCATS (CTSA
   Grant No. KL2 TR002379) , the Bristol-Myers Squibb Foundation and the
   Centers for Disease Control and Prevention (CDC, Grant No.
   CDC-DP18-1817) and the NIH/NIMHD P50 Center for Chronic Disease
   Reduction and Equity Promotion Across Minnesota (C2DREAM) Pro-gram
   (Grant No. P50MD017342) during the implementation of this work. Dr.
   Lalika received funding from the American Heart Association through the
   Research Supplement to Promote Diversity in Science (Grant No.
   23DIVSUP1067167) , while Dr. McCoy was funded by the Mayo Clinic NIH T32
   Training Program (Grant No. T32 HL07111) . Its contents are solely the
   responsibility of the authors and do not neces-sarily represent the
   official views of NCATS, NIH, or CDC. The funding bodies had no role in
   study design; in the collection, analysis, and interpretation of data;
   writing of the manuscript; and in the decision to submit the manuscript
   for publication.
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NR 79
TC 2
Z9 2
U1 1
U2 4
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1551-7144
EI 1559-2030
J9 CONTEMP CLIN TRIALS
JI Contemp. Clin. Trials
PD AUG
PY 2024
VL 143
AR 107600
DI 10.1016/j.cct.2024.107600
EA JUN 2024
PG 10
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA XB1N8
UT WOS:001259133500001
PM 38851481
DA 2025-06-11
ER

PT J
AU Fan, J
   Wang, DX
AF Fan, Jia
   Wang, Dongxu
TI Serum uric acid and nonalcoholic fatty liver disease
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Review
DE nonalcoholic fatty liver disease; serum uric acid; xanthine oxidase;
   oxidative stress; NLRP3 inflammasome; lipid metabolism; insulin
   resistance
ID INSULIN-RESISTANCE; METABOLIC SYNDROME; HEPATIC STEATOSIS; INFLAMMATION;
   ASSOCIATION; OBESITY; RISK; LEVEL; HYPERURICEMIA; ACCUMULATION
AB Nonalcoholic fatty liver disease (NAFLD) is characterized by over 5% hepatic fat accumulation without secondary causes. The prevalence of NAFLD has escalated in recent years due to shifts in dietary patterns and socioeconomic status, making it the most prevalent chronic liver disease and a significant public health concern globally. Serum uric acid (SUA) serves as the end product of purine metabolism in the body and is intricately linked to metabolic syndrome. Elevated SUA levels have been identified as an independent risk factor for the incidence and progression of NAFLD. This paper reviews the relationship between SUA and NAFLD, the underlying mechanisms of SUA involved in NAFLD, and the potential benefits of SUA-lowering therapy in treating NAFLD. The aim is to raise awareness of SUA management in patients with NAFLD, and to encourage further investigation into pharmacological interventions in this area.
C1 [Fan, Jia; Wang, Dongxu] China Med Univ, Dept Gastroenterol, Shengjing Hosp, Shenyang, Peoples R China.
C3 China Medical University
RP Wang, DX (corresponding author), China Med Univ, Dept Gastroenterol, Shengjing Hosp, Shenyang, Peoples R China.
EM dongxuwangdx@126.com
FU Liaoning Provincial Science and Technology Programme Joint Fund for
   Doctoral Research Initiation Project [2023-BSBA-349]
FX The author(s) declare financial support was received for the research,
   authorship, and/or publication of this article. This research was funded
   by Liaoning Provincial Science and Technology Programme Joint Fund for
   Doctoral Research Initiation Project, grant number 2023-BSBA-349.
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NR 118
TC 1
Z9 1
U1 9
U2 9
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD NOV 28
PY 2024
VL 15
AR 1455132
DI 10.3389/fendo.2024.1455132
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA P0U5I
UT WOS:001375169600001
PM 39669496
OA gold
DA 2025-06-11
ER

PT S
AU Jheng, HF
   Huang, SH
   Kuo, HM
   Hughes, MW
   Tsai, YS
AF Jheng, Huei-Fen
   Huang, Shin-Han
   Kuo, Hsueh-Maio
   Hughes, Michael W.
   Tsai, Yau-Sheng
GP NY Acad Sci
TI Molecular insight and pharmacological approaches targeting mitochondrial
   dynamics in skeletal muscle during obesity
SO MITOCHONDRIAL RESEARCH IN TRANSLATIONAL MEDICINE
SE Annals of the New York Academy of Sciences
LA English
DT Article; Proceedings Paper
CT 11th Conference of the
   Asian-Society-for-Mitochondrial-Research-and-Medicine - From Bench to
   Clinic (ASMRM)
CY NOV 14-15, 2014
CL Taipei, TAIWAN
SP Asian Soc Mitochondrial Res & Med
DE lipid accumulation; posttranslational modification; mitochondrial
   morphology; insulin resistance; skeletal muscle
ID INSULIN-RESISTANCE; OXIDATIVE STRESS; MITOFUSIN 2; MAMMALIAN-CELLS;
   METABOLIC SYNDROME; CANCER-CELLS; FATTY-ACIDS; E3 LIGASE; FISSION; DRP1
AB Obesity-associated insulin resistance is the major characteristic of the early stage of metabolic syndrome. A decline in mitochondrial function plays a role in the development of insulin resistance in obesity and type 2 diabetes. Accumulating data reveal that mitochondrial dynamics, the balance betweenmitochondrial fusion and fission, are an important factor in the maintenance of mitochondrial function. Thus, the mechanisms underlying the regulation of mitochondrial dynamics in obesity deserve further investigation. This review describes an overview of mitochondrial fusion and fission machineries, and discusses the mechanistic and functional aspects of mitochondrial dynamics, with a focus on skeletal muscle in obesity. Finally, we discuss current pharmacological approaches of targeting mitochondrial dynamics. Elucidating the role of mitochondrial dynamics in skeletal muscle afflicted by obesity may provide not only important clues in understanding muscle insulin resistance, but also new therapeutic targets.
C1 [Jheng, Huei-Fen; Huang, Shin-Han; Kuo, Hsueh-Maio; Hughes, Michael W.; Tsai, Yau-Sheng] Natl Cheng Kung Univ Hosp, Inst Clin Med, Tainan 70428, Taiwan.
   [Hughes, Michael W.] Natl Cheng Kung Univ, Int Res Ctr Wound Repair & Regenerat, Tainan 701, Taiwan.
   [Tsai, Yau-Sheng] Natl Cheng Kung Univ, Res Ctr Clin Med, Tainan 701, Taiwan.
C3 National Cheng Kung University; National Cheng Kung University Hospital;
   National Cheng Kung University; National Cheng Kung University
RP Tsai, YS (corresponding author), Natl Cheng Kung Univ, Inst Clin Med, 1 Univ Rd, Tainan 701, Taiwan.
EM yaustsai@mail.ncku.edu.tw
OI Hughes, Michael W./0000-0002-8899-9773
FU National Science Council [NSC-101-2320-B-006-036]; National Health
   Research Institutes [NHRI-EX104-10231SI]; National Cheng Kung University
   Aim for the Top University Project
FX This work was supported by grants from the National Science Council
   (NSC-101-2320-B-006-036), National Health Research Institutes
   (NHRI-EX104-10231SI), and National Cheng Kung University Aim for the Top
   University Project.
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NR 92
TC 26
Z9 30
U1 0
U2 8
PU BLACKWELL SCIENCE PUBL
PI OXFORD
PA OSNEY MEAD, OXFORD OX2 0EL, ENGLAND
SN 0077-8923
J9 ANN NY ACAD SCI
JI Ann.NY Acad.Sci.
PY 2015
VL 1350
BP 82
EP 94
DI 10.1111/nyas.12863
PG 13
WC Genetics & Heredity; Medicine, Research & Experimental
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Genetics & Heredity; Research & Experimental Medicine
GA BD5EZ
UT WOS:000361375900010
PM 26301786
DA 2025-06-11
ER

PT J
AU Champagne, CM
AF Champagne, Catherine M.
TI The Usefulness of a Mediterranean-Based Diet in Individuals With Type 2
   Diabetes
SO CURRENT DIABETES REPORTS
LA English
DT Article
ID LOW-GLYCEMIC INDEX; METABOLIC SYNDROME; WEIGHT-LOSS; PROSPECTIVE COHORT;
   RANDOMIZED-TRIAL; LOW-CARBOHYDRATE; HEART-DISEASE; GREEK ADULTS;
   ADHERENCE; MELLITUS
AB This article reviews current data available on the Mediterranean diet related to its use in a diabetic population. Based on many published reports, it is apparent that the Mediterranean diet may be used in dietary interventions for the treatment of overweight and obesity, conditions associated with the development of type 2 diabetes. In addition, obesity in type 2 diabetic persons is associated with other cardiovascular disease risk factors. The Mediterranean diet has been found to be inversely related to the metabolic syndrome, often a feature of diabetic individuals. Perhaps the most critical information placing the Mediterranean diet in a favorable position is the positive response of insulin, blood glucose, blood lipids, and other metabolic factors predicting cardiovascular disease risk and outcomes. This diet is a viable treatment option; advisors should stress not only adherence to a fairly traditional Mediterranean eating plan but also a lifestyle that includes sufficient physical activity.
C1 Louisiana State Univ Syst, Pennington Biomed Res Ctr, Baton Rouge, LA 70808 USA.
C3 Louisiana State University System; Louisiana State University;
   Pennington Biomedical Research Center
RP Champagne, CM (corresponding author), Louisiana State Univ Syst, Pennington Biomed Res Ctr, 6400 Perkins Rd, Baton Rouge, LA 70808 USA.
EM catherine.champagne@pbrc.edu
RI Champagne, Catherine/N-1956-2017
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NR 50
TC 11
Z9 13
U1 0
U2 12
PU CURRENT MEDICINE GROUP
PI PHILADELPHIA
PA 400 MARKET STREET, STE 700, PHILADELPHIA, PA 19106 USA
SN 1534-4827
EI 1539-0829
J9 CURR DIABETES REP
JI Curr. Diabetes Rep.
PD OCT
PY 2009
VL 9
IS 5
BP 389
EP 395
DI 10.1007/s11892-009-0060-3
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 500EI
UT WOS:000270280700009
PM 19793509
DA 2025-06-11
ER

PT J
AU Wang, J
   Ke, WX
   Bao, R
   Hu, XS
   Chen, F
AF Wang, Jing
   Ke, Weixin
   Bao, Rui
   Hu, Xiaosong
   Chen, Fang
TI Beneficial effects of ginger Zingiber officinale Roscoe on
   obesity and metabolic syndrome: a review
SO ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
LA English
DT Review
DE metabolic syndrome; Zingiber officinale; obesity; diabetes mellitus;
   mechanism
ID PROLIFERATOR-ACTIVATED RECEPTORS; PREVENTS ADIPOGENESIS;
   INSULIN-RESISTANCE; PLASMA-CHOLESTEROL; ETHANOLIC EXTRACT;
   GLUCOSE-UPTAKE; LIPID PROFILE; DIET; 6-GINGEROL; CONSUMPTION
AB In recent years, metabolic syndromes (MetSs), including diabetes mellitus, dyslipidemia, and cardiovascular diseases, have become a common health problem in both developed and developing countries. Accumulating data have suggested that traditional herbs might be able to provide a wide range of remedies in prevention and treatment of MetSs. Ginger (Zingiber officinale Roscoe, Zingiberaceae) has been documented to ameliorate hyperlipidemia, hyperglycemia, oxidative stress, and inflammation. These beneficial effects aremediated by transcription factors, such as peroxisome proliferator-activated receptors, adenosine monophosphate-activated protein kinase, and nuclear factor kappa B. This review focuses on recent findings regarding the beneficial effects of ginger on obesity and related complications in MetS and discusses its potential mechanisms of action. This review provides guidance for further applications of ginger for personalized nutrition and medicine.
C1 [Wang, Jing; Ke, Weixin; Bao, Rui; Hu, Xiaosong; Chen, Fang] China Agr Univ, Natl Engn Res Ctr Fruit & Vegetable Proc, Coll Food Sci & Nutr Engn, Minist Agr,Key Lab Fruit & Vegetable Proc, Beijing, Peoples R China.
   [Wang, Jing; Ke, Weixin; Bao, Rui; Hu, Xiaosong; Chen, Fang] China Agr Univ, Engn Res Ctr Fruit & Vegetable Proc, Minist Educ, Beijing, Peoples R China.
   [Wang, Jing; Hu, Xiaosong] China Agr Univ, Beijing Adv Innovat Ctr Food Nutr & Human Hlth, Coll Food Sci & Nutr Engn, Beijing, Peoples R China.
C3 Ministry of Agriculture & Rural Affairs; China Agricultural University;
   Ministry of Education - China; China Agricultural University; China
   Agricultural University
RP Chen, F (corresponding author), China Agr Univ, Coll Food Sci & Nutr Engn, 17 Qinghua East Rd, Beijing 100083, Peoples R China.
EM chenfangch@sina.com
RI Bao, Rui/MAH-8361-2025; Co, Annie/LBI-5115-2024; chen,
   fang/KVA-6644-2024; Wang, Jing/ABB-5658-2021
OI Wang, Jing/0000-0002-6394-5357
FU Beijing Municipal Science and Technology Project [D16110500540000]
FX Funding for this review was provided by the Beijing Municipal Science
   and Technology Project (Project No. D16110500540000).
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NR 72
TC 108
Z9 120
U1 1
U2 67
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0077-8923
EI 1749-6632
J9 ANN NY ACAD SCI
JI Ann. N.Y. Acad. Sci.
PD JUN
PY 2017
VL 1398
IS 1
SI SI
BP 83
EP 98
DI 10.1111/nyas.13375
PG 16
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA FA5BM
UT WOS:000405457600008
PM 28505392
DA 2025-06-11
ER

PT J
AU Noonan, EM
   Farrell, TW
AF Noonan, Erika M.
   Farrell, Timothy W.
TI Primary Care of the Prostate Cancer Survivor
SO AMERICAN FAMILY PHYSICIAN
LA English
DT Article
ID ANDROGEN-DEPRIVATION THERAPY; RADICAL PROSTATECTOMY; ERECTILE FUNCTION;
   INCREASED RISK; RADIATION; DIAGNOSIS; ANXIETY; IMPACT
AB This summary of the American Cancer Society Prostate Cancer Survivorship Care Guidelines targets primary care physicians who coordinate care of prostate cancer survivors with subspecialists. Prostate cancer survivors should undergo prostate-specific antigen screening every six to 12 months and digital rectal examination annually. Surveillance of patients who choose watchful waiting for their prostate cancer should be conducted by a subspecialist. Any hematuria or rectal bleeding must be thoroughly evaluated. Prostate cancer survivors should be screened regularly for urinary incontinence and sexual dysfunction. Patients with predominant urge incontinence symptoms, which can occur after surgical and radiation treatments, may benefit from an anticholinergic agent. If there is difficulty with bladder emptying, a trial of an alpha blocker may be considered. A phosphodiesterase type 5 inhibitor can effectively treat sexual dysfunction following treatment for prostate cancer. Osteoporosis screening should occur before initiation of androgen deprivation therapy, and patients treated with androgen deprivation therapy should be monitored for anemia, metabolic syndrome, and vasomotor symptoms. Healthy lifestyle choices should be encouraged, including weight management, regular physical activity, proper nutrition, and smoking cessation. Primary care physicians should be vigilant for psychosocial distress, including depression, among prostate cancer survivors, as well as the potential impact of this distress on patients' family members and partners. Copyright (C) 2016 American Academy of Family Physicians.
C1 [Noonan, Erika M.] Intermt Healthcare, Provo, UT USA.
   [Farrell, Timothy W.] Univ Utah, Sch Med, Div Geriatr, Med, Salt Lake City, UT USA.
   [Farrell, Timothy W.] Univ Utah, Sch Med, Dept Family & Prevent Med, Family Med, Salt Lake City, UT USA.
   [Farrell, Timothy W.] VA Salt Lake City Geriatr Res Educ & Clin Ctr, Salt Lake City, UT USA.
C3 Intermountain Healthcare; Intermountain Medical Center; Utah System of
   Higher Education; University of Utah; Utah System of Higher Education;
   University of Utah; Geriatric Research Education & Clinical Center; US
   Department of Veterans Affairs
RP Noonan, EM (corresponding author), 3200 North Canyon Rd,Ste C, Provo, UT 84604 USA.
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TC 7
Z9 8
U1 0
U2 7
PU AMER ACAD FAMILY PHYSICIANS
PI KANSAS CITY
PA 8880 WARD PARKWAY, KANSAS CITY, MO 64114-2797 USA
SN 0002-838X
EI 1532-0650
J9 AM FAM PHYSICIAN
JI Am. Fam. Physician
PD MAY 1
PY 2016
VL 93
IS 9
BP 764
EP 770
PG 7
WC Primary Health Care; Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA DL1BW
UT WOS:000375368000008
PM 27175954
DA 2025-06-11
ER

PT J
AU Agarwal, A
   Rana, M
   Qiu, E
   AlBunni, H
   Bui, AD
   Henkel, R
AF Agarwal, Ashok
   Rana, Mohit
   Qiu, Emily
   AlBunni, Hashem
   Bui, Albert D.
   Henkel, Ralf
TI Role of oxidative stress, infection and inflammation in male infertility
SO ANDROLOGIA
LA English
DT Review
DE causes of oxidative stress; male genital tract infections; oxidative
   stress; sexually transmitted diseases
ID HEPATITIS-C-VIRUS; CHLAMYDIA-TRACHOMATIS INFECTIONS; PLASMA-MEMBRANE
   INTEGRITY; IN-VITRO FERTILIZATION; UREAPLASMA-UREALYTICUM;
   LIPID-PEROXIDATION; SEMINAL PLASMA; SEMEN QUALITY; CIGARETTE-SMOKING;
   ESCHERICHIA-COLI
AB Oxidative stress (OS), defined as an overabundance of reactive oxygen species (ROS) or a deficiency of antioxidants, has been linked to sperm damage and male infertility. There are many sources of OS and inflammation including varicocele, tobacco usage, alcohol, obesity/metabolic syndrome, leukocytospermia, sexually transmitted disease (i.e., Neisseria gonorrhoeae, Chlamydia trachomatis, Treponema pallidum), bacterial prostatitis, microorganism mutations leading to more OS, and viral infections (i.e., human immunodeficiency virus, hepatitis). This review is focusing on infection and inflammation-mediated OS, the inflammatory markers underlying pathology, clinical significance in male infertility, and a brief description of the recommended treatment modalities.
C1 [Agarwal, Ashok; Rana, Mohit; Qiu, Emily; AlBunni, Hashem; Bui, Albert D.; Henkel, Ralf] Cleveland Clin, Amer Ctr Reprod Med, Cleveland, OH 44195 USA.
   [Bui, Albert D.] Ohio Univ, Heritage Coll Osteopath Med, Athens, OH 45701 USA.
   [Henkel, Ralf] Univ Western Cape, Dept Med Biosci, Bellville, South Africa.
C3 Cleveland Clinic Foundation; University System of Ohio; Ohio University;
   University of the Western Cape
RP Agarwal, A (corresponding author), Cleveland Clin, Amer Ctr Reprod Med, Cleveland, OH 44195 USA.
EM agarwaa@ccf.org
OI Henkel, Ralf/0000-0003-1128-2982
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NR 165
TC 201
Z9 206
U1 0
U2 32
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0303-4569
EI 1439-0272
J9 ANDROLOGIA
JI Andrologia
PD DEC
PY 2018
VL 50
IS 11
SI SI
AR e13126
DI 10.1111/and.13126
PG 13
WC Andrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA HE9SW
UT WOS:000453795800006
PM 30569652
DA 2025-06-11
ER

PT J
AU Izumida, T
   Nakamura, Y
   Sato, Y
   Ishikawa, S
AF Izumida, Toshihide
   Nakamura, Yosikazu
   Sato, Yukihiro
   Ishikawa, Shizukiyo
TI The Association Between Sleeping Pill Use and Metabolic Syndrome in an
   Apparently Healthy Population in Japan: JMS-II Cohort Study
SO JOURNAL OF EPIDEMIOLOGY
LA English
DT Article
DE sleeping pills; metabolic syndrome; cardiovascular disease; epidemiology
ID QUALITY INDEX; DURATION; BENZODIAZEPINES; ZOLPIDEM; INSOMNIA; RISK;
   RESTRICTION; DEPRESSION; QUESTIONS; SYMPTOMS
AB Background: Sleeping pills are widely used for sleep disorders and insomnia. This population-based study aimed to evaluate the association between the use of sleeping pills and metabolic syndrome (MetS) and metabolic components in an apparently healthy Japanese cohort.
   Methods: We examined baseline cross-sectional data from the JMS-II Cohort Study. The criteria for MetS and its components were based on The National Cholesterol Education Program Adult Treatment Panel III. Sleep habits including the sleep duration of the subjects and the frequency of sleeping pill use were obtained using The Pittsburgh Sleep Quality Index questionnaire. For different sleep durations, the association between sleeping pill use and MetS was assessed. Odds ratios (ORs) and their 95% confidence intervals (CIs) were estimated using multiple logistic regression models to quantify this association.
   Results: Our study included 6,153 individuals (mean age, 63.8 [standard deviation 11.2] years), and 3,348 (54.4%) among them were women. The association between sleep duration and MetS was an inverted J-shaped curve among sleeping pill users and a J-shaped curve among non-users. After adjustment for various confounders, less than 6 h of sleep among sleeping pill users was associated with increased rates of MetS (<6 h, OR 3.08; 95% CI, 1.29-7.34]). The frequency of sleeping pill use in individuals with short sleep duration showed a positive association with the prevalence of MetS and its components.
   Conclusions: Sleeping pill users with a short sleep duration had a 3-fold higher chance of having MetS than non-users with a short sleep duration.
C1 [Izumida, Toshihide] Kanawaza Med Univ Himi Municipal Hosp, Div Community Med, Himi, Toyama, Japan.
   [Nakamura, Yosikazu; Ishikawa, Shizukiyo] Jichi Med Univ, Ctr Community Med, Div Publ Hlth, 3311-1 Yakushiji, Shimotsuke, Tochigi 3290498, Japan.
   [Sato, Yukihiro] Kamiichi Gen Hosp, Internal Med, Toyama, Japan.
C3 Jichi Medical University
RP Ishikawa, S (corresponding author), Jichi Med Univ, Ctr Community Med, Div Publ Hlth, 3311-1 Yakushiji, Shimotsuke, Tochigi 3290498, Japan.
EM i-shizu@jichi.ac.jp
FU MEXT-Supported Program for the Strategic Research Foundation at Private
   Universities [S0901032]; Japanese Society for the Promotion of Science
   KAKENHI [16K09141]; Ministry of Health, Labour, and Welfare; Health and
   Labor Sciences and Japan Comprehensive Research on Cardiovascular and
   Lifestyle-Related Diseases [H26-Junkankitou- [Seisaku] -Ippan-001,
   H29-Junkankitou-Ippan-003]; IRB [G09-39 [G17-64]]; Jichi Medical
   University Alumni Association Project Grant [2020 [5-3]]; Grants-in-Aid
   for Scientific Research [16K09141] Funding Source: KAKEN
FX Financial support: This research was supported by the MEXT-Supported
   Program for the Strategic Research Foundation at Private Universities
   (S0901032) ; a Japanese Society for the Promotion of Science KAKENHI
   grant (No. 16K09141) ; a Grant-In-Aid from the Ministry of Health,
   Labour, and Welfare; Health and Labor Sciences and Japan Comprehensive
   Research on Cardiovascular and Lifestyle-Related Diseases grants
   (H26-Junkankitou- [Seisaku] -Ippan-001 and H29-Junkankitou-Ippan-003;
   IRB No. G09-39 [G17-64 revised] ) ; and Jichi Medical University Alumni
   Association Project Grant 2020 [5-3] .
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NR 40
TC 5
Z9 5
U1 0
U2 4
PU JAPAN EPIDEMIOLOGICAL ASSOC
PI TOKYO
PA HONGO MT BLDG, 4 FL, 7-2-2, HONGO, BUNKYO-KU, TOKYO, JAPAN
SN 0917-5040
J9 J EPIDEMIOL
JI J. Epidemiol.
PD MAR
PY 2022
VL 32
IS 3
BP 145
EP 150
DI 10.2188/jea.JE20200361
PG 6
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA YX4CE
UT WOS:000754052700001
PM 33162423
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Pataky, Z
   Carrard, I
   Gay, V
   Thomas, A
   Carpentier, A
   Bobbioni-Harsch, E
   Golay, A
AF Pataky, Zoltan
   Carrard, Isabelle
   Gay, Valerie
   Thomas, Aurelien
   Carpentier, Anne
   Bobbioni-Harsch, Elisabetta
   Golay, Alain
TI Effects of a Weight Loss Program on Metabolic Syndrome, Eating Disorders
   and Psychological Outcomes: Mediation by Endocannabinoids?
SO OBESITY FACTS
LA English
DT Article
DE Weight loss; Metabolic syndrome; Endocannabinoids; Eating disorders;
   Quality of life; Patient education
ID LIFE-STYLE INTERVENTION; GASTRIC BYPASS; OBESE-PATIENTS; FATTY-ACIDS;
   DIETARY-FAT; RISK; REDUCTION; PLASMA; INDIVIDUALS; MANAGEMENT
AB Objective: To evaluate the effects of weight loss on endocannabinoids, cardiometabolic and psychological parameters, eating disorders (ED) as well as quality of life (QoL) and to elucidate the role of endocannabinoids in metabolic syndrome (MS). Methods: In total, 114 patients with obesity were prospectively included in a 12-month weight loss program. Plasma endocannabinoids were measured by mass spectrometry; ED, psychological and QoL-related parameters were evaluated by self-reported questionnaires; physical activity was measured by accelerometer. Nutritional assessment was done by a 3-day food diary. Results: Among completers (n = 87), body weight decreased in 35 patients (-9.1 +/- 8.6 kg), remained stable in 39 patients, and increased in 13 patients (+5.8 +/- 3.4 kg). 75% of patients with MS at baseline were free of MS at follow-up, and their baseline plasma N-palmitoylethanolamide (PEA) values were significantly lower when compared to patients with persisting MS. At baseline, there was a positive relationship between PEA and waist circumference (p = 0.005, R-2 = 0.08), fasting glucose (p < 0.0001, R-2 - 0.12), total cholesterol (p = 0.001, R-2 - 0.11), triglycerides (p = 0.001, R-2 = 0.11), LDL-cholesterol (p = 0.03, R-2 = 0.05) as well as depression score (p = 0.002, R-2 = 0.29). Conclusion: Plasma PEA might play a role in metabolic improvement after weight loss. Even in subjects without weight loss, a multidisciplinary intervention improves psychological outcomes, ED, and QoL. (C) 2018 The Author(s) Published by S. Karger GmbH, Freiburg
C1 [Pataky, Zoltan; Carrard, Isabelle; Gay, Valerie; Carpentier, Anne; Bobbioni-Harsch, Elisabetta; Golay, Alain] Univ Hosp Geneva, WHO, Collaborating Ctr, Serv Therapeut Educ Chron Dis, Geneva, Switzerland.
   [Pataky, Zoltan; Carrard, Isabelle; Gay, Valerie; Thomas, Aurelien; Carpentier, Anne; Bobbioni-Harsch, Elisabetta; Golay, Alain] Univ Geneva, Geneva, Switzerland.
   [Carrard, Isabelle] Univ Appl Sci & Arts Western Switzerland HES SO, Sch Hlth Sci, Dept Nutr & Dietet, Geneva, Switzerland.
   [Thomas, Aurelien] Univ Hosp Geneva, CURML, Unit Toxicol, Geneva, Switzerland.
C3 World Health Organization; University of Geneva; University of Geneva;
   University of Geneva
RP Pataky, Z (corresponding author), Univ Hosp Geneva, Serv Therapeut Educ Chron Dis, Chemin Venel 7, CH-1206 Geneva, Switzerland.
EM zoltan.pataky@hcuge.ch
RI Allet, Lara/C-2994-2009
OI Pataky, Zoltan/0000-0002-8720-3833; Carrard,
   Isabelle/0000-0002-2384-6696; Thomas, Aurelien/0000-0001-6790-2285
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NR 43
TC 13
Z9 14
U1 0
U2 7
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1662-4025
EI 1662-4033
J9 OBESITY FACTS
JI Obes. Facts
PY 2018
VL 11
IS 2
BP 144
EP 156
DI 10.1159/000487890
PG 13
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA GG5NK
UT WOS:000432742400007
PM 29631275
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Sicras-Mainar, A
   Ruíz-Beato, E
   Navarro-Artieda, R
   Maurino, J
AF Sicras-Mainar, Antoni
   Ruiz-Beato, Elena
   Navarro-Artieda, Ruth
   Maurino, Jorge
TI Comorbidity and metabolic syndrome in patients with multiple sclerosis
   from Asturias and Catalonia, Spain
SO BMC NEUROLOGY
LA English
DT Article
DE Comorbidity; Metabolic syndrome; Multiple sclerosis; Electronic medical
   records
ID PREVALENCE; POPULATION; DISEASES; RISK
AB Background: The impact of comorbidity on multiple sclerosis (MS) is a new area of interest. Limited data on the risk factors of metabolic syndrome (MetS) is currently available. The aim of this study was to estimate the presence of comorbid conditions and MetS in a sample of adult patients with MS.
   Methods: A retrospective, cohort study was conducted using electronic medical records from 19 primary care centres in Catalonia and Asturias, Spain. The number of chronic diseases (diagnoses), the Charlson Comorbidity Index and the individual Case- mix Index were used to assess general comorbidity variables. MetS was defined using the National Cholesterol Education Program Adult Treatment Panel III. Patients were distributed into two groups according to the Expanded Disability Status Scale (EDSS) score: 0- 3.5 and 4- 10.
   Results: A total of 222 patients were studied (mean age = 45.5 (SD 12.5) years, 64.4% were female and 62.2% presented a diagnosis of relapsing- remitting MS). Mean EDSS score was 3.2 (SD 2.0). Depression (32.4%), dyslipidaemia (31.1%), hypertension (23.0%) and obesity (22.5%) were the most common comorbidities. Overall MetS prevalence was 31.1% (95% CI: 25.0- 37.2%). Patients with an EDSS >= 4.0 showed a significantly higher number of comorbidities (OR= 2.2; 95% CI: 1.7- 3.0; p< 0.001).
   Conclusion: MS patients had a high prevalence of MetS. Screening for comorbidity should be part of standard MS care. Further studies are necessary to confirm this association and the underlying mechanisms of MS and its comorbidities.
C1 [Sicras-Mainar, Antoni] Fdn Rediss Red Invest Serv Sanitarios, Barcelona, Spain.
   [Ruiz-Beato, Elena] Roche Farma SA, Hlth Econ & Outcomes Res Unit, Madrid, Spain.
   [Navarro-Artieda, Ruth] Hosp Badalona Germans Trias & Pujol, Dept Med Informat, Barcelona, Spain.
   [Maurino, Jorge] Roche Farma SA, Dept Med, Madrid, Spain.
C3 Hospital Germans Trias i Pujol; Roche Holding; ROCHE HOLDING SPAIN
RP Maurino, J (corresponding author), Roche Farma SA, Dept Med, Madrid, Spain.
EM jorge.maurino@roche.com
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NR 34
TC 35
Z9 36
U1 0
U2 1
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2377
J9 BMC NEUROL
JI BMC Neurol.
PD JUL 17
PY 2017
VL 17
AR 134
DI 10.1186/s12883-017-0914-2
PG 6
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA FA8MP
UT WOS:000405700400002
PM 28716070
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Carney, R
   Cotter, J
   Bradshaw, T
   Yung, AR
AF Carney, Rebekah
   Cotter, Jack
   Bradshaw, Tim
   Yung, Alison R.
TI Examining the physical health and lifestyle of young people at
   ultra-high risk for psychosis: A qualitative study involving service
   users, parents and clinicians
SO PSYCHIATRY RESEARCH
LA English
DT Article
DE Psychosis; Prodrome; At-risk mental state; Metabolic health; Health
   promotion
ID NEGATIVE SYMPTOMS; EXERCISE; NEUROCOGNITION; INDIVIDUALS; STATE; TIME
AB Emerging evidence suggests young people at ultra-high risk for psychosis (UHR) are also at-risk for poor physical health, and display high rates of modifiable cardiometabolic risk factors. However, before we can develop effective interventions there is a need to understand factors affecting lifestyle choices in the UHR group. We conducted semi-structured qualitative interviews with 20 UHR individuals (50% male; mean age 21.7), 5 parents (4 mothers, 1 father), and 6 clinicians from early intervention services in the Northwest of England to identify barriers and facilitators to living a healthy lifestyle, including achieving regular exercise, eating well and refraining from excessive substance use. Thematic analysis revealed the main barriers to living a healthy lifestyle related to psychiatric symptoms, beliefs about self, social withdrawal and practical considerations such as accessibility and cost. Provision of social support and promoting autonomy emerged as the two main themes which would facilitate a healthy lifestyle. Promoting physical health in people with emerging symptoms of psychosis is an important, yet neglected area of mental health practice and warrants further investigation. UHR individuals experience numerous barriers to living a healthy lifestyle, and interventions should focus primarily on targeting autonomous motivation and providing social support to facilitate this change.
C1 [Carney, Rebekah; Cotter, Jack; Yung, Alison R.] Univ Manchester, Div Psychol & Mental Hlth, Room 3-306,Jean McFarlane Bldg,Oxford Rd, Manchester M13 9PL, Lancs, England.
   [Bradshaw, Tim] Univ Manchester, Div Nursing Midwifery & Social Work, Manchester, Lancs, England.
   [Yung, Alison R.] Greater Manchester West Mental Hlth NHS Fdn Trust, Manchester, Lancs, England.
C3 University of Manchester; University of Manchester
RP Carney, R (corresponding author), Univ Manchester, Div Psychol & Mental Hlth, Room 3-306,Jean McFarlane Bldg,Oxford Rd, Manchester M13 9PL, Lancs, England.
EM rebekah.rebekah@postgrad.manchester.ac.uk
RI Carney, Rebekah/AAO-5205-2021; Yung, Alison/N-6729-2019
OI Yung, Alison/0000-0002-0401-9791; Carney, Rebekah/0000-0002-2859-6825
FU Economic and Social Research Council [ES/J500094/1]
FX R.C is supported by the Economic and Social Research Council
   [ES/J500094/1]. We would like to thank all participants and staff
   members who assisted with recruitment at the participating sites. We
   would like to extend particular thanks to Matt Riley for helping us
   throughout the course of the study.
CR [Anonymous], EARLY INTERV PSYCHIA
   [Anonymous], PSYCHIAT RES
   [Anonymous], SCHIZOPHR B
   [Anonymous], PSYCHIAIR Q
   [Anonymous], AUST N Z J PSYCHIAT
   [Anonymous], SELL DETERMINATION
   [Anonymous], 2016, Implementing the Early Intervention in Psychosis access and Waiting Time standard: Guidance
   [Anonymous], 2015, NVivo qualitative data analysis Software
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NR 39
TC 26
Z9 34
U1 0
U2 13
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0165-1781
EI 1872-7123
J9 PSYCHIAT RES
JI Psychiatry Res.
PD SEP
PY 2017
VL 255
BP 87
EP 93
DI 10.1016/j.psychres.2017.05.023
PG 7
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA FE4IO
UT WOS:000408177800014
PM 28531821
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Peleli, M
   Hezel, M
   Zollbrecht, C
   Persson, AEG
   Lundberg, JO
   Weitzberg, E
   Fredholm, BB
   Carlström, M
AF Peleli, Maria
   Hezel, Michael
   Zollbrecht, Christa
   Persson, A. Erik G.
   Lundberg, Jon O.
   Weitzberg, Eddie
   Fredholm, Bertil B.
   Carlstrom, Mattias
TI In adenosine A2B knockouts acute treatment with inorganic
   nitrate improves glucose disposal, oxidative stress, and AMPK signaling
   in the liver
SO FRONTIERS IN PHYSIOLOGY
LA English
DT Article
DE insulin resistance; metabolic syndrome; NADPH oxidase; nitric oxide;
   nitrite; superoxide; obesity; type 2 diabetes
ID ACTIVATED PROTEIN-KINASE; NITRIC-OXIDE; DIETARY NITRATE; NADPH OXIDASE;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; BLOOD-PRESSURE; ENDOTHELIAL
   FUNCTION; NAD(P)H OXIDASE; ADIPOSE-TISSUE
AB Rationale: Accumulating studies suggest that nitric oxide (NO) deficiency and oxidative stress are central pathological mechanisms in type 2 diabetes (T2D). Recent findings demonstrate therapeutic effects by boosting the nitrate-nitrite-NO pathway, which is an alternative pathway for NO formation. This study aimed at investigating the acute effects of inorganic nitrate on glucose and insulin signaling in adenosine A2B receptor knockout mice (A(2B)(-/-), a genetic mouse model of impaired metabolic regulation.
   Methods: Acute effects of nitrate treatment were investigated in aged wild-type (WT) and A(2B)(-/-) mice. One hour after injection with nitrate (0.1 mmol/kg, i.p.) or placebo, metabolic regulation was evaluated by intraperitoneal glucose and insulin tolerance tests. NADPH oxidase-mediated superoxide production and AMPK phosphorylation were measured in livers obtained from non-treated or glucose-treated mice, with or without prior nitrate injection. Plasma was used to determine insulin resistance (HOMA-IR) and NO signaling.
   Results: A(2B)(-/-) displayed increased body weight, reduced glucose clearance, and attenuated overall insulin responses compared with age-matched WT mice. Nitrate treatment increased circulating levels of nitrate, nitrite and cGMP in the A(2B)(-/-), and improved glucose clearance. In WT mice, however, nitrate treatment did not influence glucose clearance. HOMA-IR increased following glucose injection in the A(2B)(-/-), but remained at basal levels in mice pretreated with nitrate. NADPH oxidase activity in livers from A(2B)(-/-), but not WT mice, was reduced by nitrate treatment. Livers from A(2B)(-/-) displayed reduced AMPK phosphorylation compared with WT mice, and this was increased by nitrate treatment. Finally, injection with the anti-diabetic agent metformin induced similar therapeutic effects in the A(2B)(-/-) as observed with nitrate.
   Conclusion: The A(2B)(-/-) mouse is a genetic mouse model of metabolic syndrome. Acute treatment with nitrate improved the metabolic profile in it, at least partly via reduction in oxidative stress and improved AMPK signaling in the liver.
C1 [Peleli, Maria; Hezel, Michael; Zollbrecht, Christa; Lundberg, Jon O.; Weitzberg, Eddie; Fredholm, Bertil B.; Carlstrom, Mattias] Karolinska Inst, Dept Physiol & Pharmacol, S-17177 Stockholm, Sweden.
   [Persson, A. Erik G.] Uppsala Univ, Dept Med Cell Biol, Stockholm, Sweden.
C3 Karolinska Institutet; Uppsala University
RP Carlström, M (corresponding author), Karolinska Inst, Dept Physiol & Pharmacol, Nanna Svartz Vag 2, S-17177 Stockholm, Sweden.
EM mattias.carlstrom@ki.se
RI Peleli, Maria/AAQ-2326-2021; Carlstrom, Mattias/E-7350-2015
OI Lundberg, Jon/0000-0002-0174-5210; Carlstrom,
   Mattias/0000-0001-9923-8729
FU Swedish Research Council [521-2011-2639]; Swedish Heart and Lung
   Foundation [20140448]; David and Astrid Hagelen Foundation; Jeanssons
   Foundation [J520 13-00064]; Stockholm City Council (ALF); Bodossaki
   Foundation (Athens, Greece); Karolinska Institutet
FX We thank Eva Lindgren, Annika Olsson, Carina Nihlen, and Margareta
   Stensdotter (Department of Physiology and Pharmacology, Karolinska
   Institutet) for excellent technical contribution. This work was
   supported by grants from the Swedish Research Council (521-2011-2639),
   the Swedish Heart and Lung Foundation (20140448), David and Astrid
   Hagelen Foundation, Jeanssons Foundation (J520 13-00064), Stockholm City
   Council (ALF), the Bodossaki Foundation (Athens, Greece), and by
   KID-funding from the Karolinska Institutet.
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NR 48
TC 39
Z9 44
U1 0
U2 6
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1664-042X
J9 FRONT PHYSIOL
JI Front. Physiol.
PD AUG 7
PY 2015
VL 6
AR 222
DI 10.3389/fphys.2015.00222
PG 9
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA CQ2ZS
UT WOS:000360471900002
PM 26300787
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Fosså, SD
   Fung, C
   Dahl, AA
AF Fossa, S. D.
   Fung, C.
   Dahl, A. A.
TI Late adverse outcomes after treatment of testicular cancer
SO ONKOLOGE
LA English
DT Review
DE Cancer survivors; Mortality; Cardiovascular disease; Risk factors;
   Toxicity
ID GERM-CELL CANCER; LONG-TERM; AMERICAN SOCIETY; RENAL-FUNCTION;
   SURVIVORS; CHEMOTHERAPY; BLEOMYCIN; CISPLATIN; FATIGUE; NONSEMINOMA
AB Background. Modern oncological treatment has rendered testicular cancer (TC) a curative malignant disease but there is a risk of decreasing survival and reduced healthrelated quality of life (HR-QoL) related to long-termadverse health outcomes (AHOs).
   Aim. To provide an overview on AHOs after oncological treatment of TC.
   Material and methods. Summary of published studies and previous reviews.
   Results. Relative survival rates decrease among TC survivors 25 years after diagnosis, mainly due to treatment-related second cancer and/or cardiovascular disease, the latter mediated by components of the metabolic syndrome. With increasing age cisplatin-induced ototoxicity becomes a clinical problem in patients, whereas reported peripheral neurotoxicity only exceptionally achieves major clinical relevance. Anxiety but not depression represents the dominating psychological problem. In most patients HR-QoL is good, but working abilitymay be reduced by very intensive treatment.
   Conclusion. Awareness of long-term AHOs among TC survivors and health professionals can contribute to reduce long-term morbidity and mortality and to improve QoL by initiating early preventive and therapeutic measures. Radiotherapy should be avoided as much as possible during risk-adapted treatment of TC. Existing data indicate premature aging among strongly treated TC survivors but larger studies and longer follow-up in longitudinal studies are required to confirm these preliminary observations.
C1 [Fossa, S. D.; Dahl, A. A.] Oslo Univ Hosp, Norwegian Radium Hosp, Natl Advisory Unit Late Effects Canc Treatment, Dept Oncol, Pb 4953, N-0424 Oslo, Norway.
   [Fung, C.] Univ Rochester, Med Ctr, James P Wilmot Canc Inst, Rochester, NY 14627 USA.
C3 University of Oslo; University of Rochester
RP Fosså, SD (corresponding author), Oslo Univ Hosp, Norwegian Radium Hosp, Natl Advisory Unit Late Effects Canc Treatment, Dept Oncol, Pb 4953, N-0424 Oslo, Norway.
EM sopfos@ous-hf.no
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NR 31
TC 3
Z9 5
U1 0
U2 7
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0947-8965
EI 1433-0415
J9 ONKOLOGE
JI Onkologe
PD NOV
PY 2018
VL 24
SU 2
BP S104
EP S109
DI 10.1007/s00761-018-0442-8
PG 6
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA GZ8QL
UT WOS:000449757500003
DA 2025-06-11
ER

PT J
AU Marrone, G
   Basilicata, M
   Di Lauro, M
   Vita, C
   Masci, C
   Klinger, FG
   Cornali, K
   Maddaloni, G
   Bollero, P
   De Lorenzo, A
   Noce, A
AF Marrone, Giulia
   Basilicata, Michele
   Di Lauro, Manuela
   Vita, Chiara
   Masci, Claudia
   Klinger, Francesca Gioia
   Cornali, Kevin
   Maddaloni, Gianluca
   Bollero, Patrizio
   De Lorenzo, Antonino
   Noce, Annalisa
TI Healthy Effects of Pomegranate (Punica granatum L.) in Internal
   Medicine and Dentistry
SO APPLIED SCIENCES-BASEL
LA English
DT Review
DE ellagitannins; ellagic acid; circular economy; chronic non-communicable
   diseases; cancer; metabolic syndrome; oral health; periodontitis
ID PROSTATE-CANCER CELLS; ELLAGIC ACID; IN-VITRO; OXIDATIVE STRESS; FRUIT
   EXTRACT; COLON-CANCER; GENE-EXPRESSION; FLOWER EXTRACT; PLANT-EXTRACTS;
   PEEL EXTRACTS
AB Punica granatum L., commonly known as pomegranate, is a typical fruit of Asia, Mediterranean countries, the Middle East and the USA. While in ancient times pomegranate was considered an ornamental plant, nowadays numerous scientific studies have highlighted its antioxidant and anti-radical activities, making it a "superfood". Pomegranate presents a high content of natural bioactive compounds (NBCs), and its consumption appears to exert numerous healthy effects, in particular, in several pathological conditions as metabolic syndrome, cancer, nephrolithiasis, urinary tract infections and neurodegenerative diseases. Moreover, recent studies have pointed out the possible beneficial action of pomegranate on oral health. For these reasons, the utility of pomegranate in internal medicine and dentistry represents a promising field, as it could enable the development of innovative natural adjuvant therapies and empower standard pharmaceutical therapies.
C1 [Marrone, Giulia; Di Lauro, Manuela; Masci, Claudia; Cornali, Kevin; Noce, Annalisa] Univ Roma Tor Vergata, Dept Syst Med, UOSD Nephrol & Dialysis, I-00133 Rome, Italy.
   [Basilicata, Michele] Univ Roma Tor Vergata, Dept Expt Med & Surg, UOSD Special Care Dent, I-00133 Rome, Italy.
   [Basilicata, Michele; Klinger, Francesca Gioia] St Camillus Int Univ Hlth & Med Sci, Rome, Italy.
   [Vita, Chiara] Univ Ctr Citta Prato Educ, Sci Serv Univ Florence, QuMAP PIN, I-59100 Prato, Italy.
   [Maddaloni, Gianluca] Supreme Fruit SRL, I-04012 Cisterna Latina, Italy.
   [Bollero, Patrizio] Univ Roma Tor Vergata, Dept Syst Med, UOSD Special Care Dent, I-00133 Rome, Italy.
   [De Lorenzo, Antonino] Univ Roma Tor Vergata, Dept Biomed & Prevent, Sect Clin Nutr & Nutrigen, Via Montpellier 1, I-00133 Rome, Italy.
C3 University of Rome Tor Vergata; University of Rome Tor Vergata;
   University of Rome Tor Vergata; University of Rome Tor Vergata
RP Di Lauro, M (corresponding author), Univ Roma Tor Vergata, Dept Syst Med, UOSD Nephrol & Dialysis, I-00133 Rome, Italy.; Basilicata, M (corresponding author), Univ Roma Tor Vergata, Dept Expt Med & Surg, UOSD Special Care Dent, I-00133 Rome, Italy.; Basilicata, M (corresponding author), St Camillus Int Univ Hlth & Med Sci, Rome, Italy.
EM giulia.marrone@uniroma2.it; michele.basilicata@ptvonline.it;
   manuela.dilauro@ptvonline.it; chiara.vita@pin.unifi.it;
   masciclaudia@gmail.com; francesca.klinger@unicamillus.org;
   cornali.kevin@hotmail.it; gianluca7519@gmail.com;
   patrizio.bollero@ptvonline.it; annalisa.noce@uniroma2.it
RI Klinger, Francesca Gioia/K-6587-2018; Marrone, Giulia/IQR-7760-2023;
   Vita, Chiara/LSI-6514-2024; Noce, Annalisa/B-5558-2019; Di Lauro,
   Manuela/AAB-9784-2022
OI NOCE, ANNALISA/0000-0003-1310-3730; De Lorenzo,
   Antonino/0000-0001-6524-4493; Klinger, Francesca
   Gioia/0000-0001-6744-0850; Di Lauro, Manuela/0000-0001-8118-1330;
   Marrone, Giulia/0000-0002-5854-2086
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NR 181
TC 8
Z9 8
U1 2
U2 8
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3417
J9 APPL SCI-BASEL
JI Appl. Sci.-Basel
PD FEB
PY 2024
VL 14
IS 4
AR 1570
DI 10.3390/app14041570
PG 29
WC Chemistry, Multidisciplinary; Engineering, Multidisciplinary; Materials
   Science, Multidisciplinary; Physics, Applied
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Engineering; Materials Science; Physics
GA JI5G5
UT WOS:001172543500001
OA Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Robberecht, H
   Hermans, N
AF Robberecht, Harry
   Hermans, Nina
TI Biomarkers of Metabolic Syndrome: Biochemical Background and Clinical
   Significance
SO METABOLIC SYNDROME AND RELATED DISORDERS
LA English
DT Review
ID C-REACTIVE PROTEIN; ACID-BINDING PROTEIN; GAMMA-GLUTAMYL-TRANSFERASE;
   NONALCOHOLIC FATTY LIVER; CORONARY-ARTERY-DISEASE; SERUM URIC-ACID;
   NECROSIS-FACTOR-ALPHA; MONOCYTE CHEMOATTRACTANT PROTEIN-1;
   CARDIOVASCULAR RISK-FACTORS; EPITHELIUM-DERIVED FACTOR
AB Biomarkers of the metabolic syndrome are divided into four subgroups. Although dividing them in groups has some limitations, it can be used to draw some conclusions. In a first part, the dyslipidemias and markers of oxidative stress are discussed, while inflammatory markers and cardiometabolic biomarkers are reviewed in a second part. For most of them, the biochemical background and clinical significance are discussed, although here also a well-cut separation cannot always be made. Altered levels cannot always be claimed as the cause, risk, or consequence of the syndrome. Several factors are interrelated to each other and act in a concerted, antagonistic, synergistic, or modulating way. Most important conclusions are summarized at the end of every reviewed subgroup. Genetic biomarkers or influences of various food components on concentration levels are not included in this review article.
C1 [Robberecht, Harry; Hermans, Nina] Univ Antwerp, Dept Pharmaceut Sci, NatuRA Nat Prod & Food Res & Anal, Univ Pl 1, B-2610 Antwerp, Belgium.
C3 University of Antwerp
RP Robberecht, H (corresponding author), Univ Antwerp, Dept Pharmaceut Sci, NatuRA Nat Prod & Food Res & Anal, Univ Pl 1, B-2610 Antwerp, Belgium.
EM labrom@ua.ac.be
RI Hermans, Nina/A-5244-2017
OI Hermans, Nina/0000-0003-3946-7313
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NR 953
TC 27
Z9 28
U1 1
U2 26
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-4196
EI 1557-8518
J9 METAB SYNDR RELAT D
JI Metab. Syndr. Relat. Disord.
PD MAR 1
PY 2016
VL 14
IS 2
BP 47
EP 93
DI 10.1089/met.2015.0113
PG 47
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA DG0BO
UT WOS:000371727100001
PM 26808223
DA 2025-06-11
ER

PT J
AU Vieweg, WVR
   Sood, AB
   Pandurangi, A
   Silverman, JJ
AF Vieweg, WVR
   Sood, AB
   Pandurangi, A
   Silverman, JJ
TI Application of body mass index principles in a model elementary school:
   Implications for overweight and obese children
SO JOURNAL OF THE NATIONAL MEDICAL ASSOCIATION
LA English
DT Article
DE adolescents; anxiety; body mass index; cardiovascular disease; children;
   depression; diabetes mellitus; elementary school; Epi Info; ethnicity;
   inner-city schools; growth charts; metabolic syndrome; metabolic
   syndrome; nutstat; obesity; overweight; public school; type-2 diabetes
   mellitus
ID ADOLESCENTS; TRENDS; PREVALENCE; WEIGHT; LIFE
AB The first model elementary school in Richmond, VA formed the study site for this project. Changes in this model will lay the groundwork for changes throughout the Richmond Public School System. Of the 283 students in grades one through five, 66 students (23.3%) were randomly selected. Of the 66 students, 54 (81.8%) were black. Each student underwent height and weight measurement. Using the Nutstat module of the Centers for Disease Control (CDC) Epi Info software program available at no cost on the Internet, we identified Body Mass Index (BMI), BMI percentile for sex and age, and z-score for each student.
   Z-score measurements placed the 19 black male children at the 98.08th percentile for BMI (fewer than 2% of U.S. male children were larger). Similarly, the 35 black female children's BMI was at the 95.35th percentile (fewer than 5% of U.S. female children were larger). Based on data in the literature, the typical black male and female elementary child included in our study can expect a significant reduction in life expectancy compared with their nonobese counterparts.
C1 Virginia Commonwealth Univ, Med Coll Virginia, Dept Psychiat, Richmond, VA 23298 USA.
C3 Virginia Commonwealth University
RP Vieweg, WVR (corresponding author), 17 Runswick Dr, Richmond, VA USA.
EM vvieweg@hsc.vcu.edu
RI Lam, Raymond/D-2529-2013
CR [Anonymous], 2000, ADV DATA, V314, P1
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NR 14
TC 2
Z9 2
U1 0
U2 4
PU NATL MED ASSOC
PI WASHINGON
PA 1012 10TH ST, N W, WASHINGON, DC 20001 USA
SN 0027-9684
J9 J NATL MED ASSOC
JI J. Natl. Med. Assoc.
PD APR
PY 2004
VL 96
IS 4
BP 468
EP 475
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 851DI
UT WOS:000223665200030
PM 15101667
DA 2025-06-11
ER

PT J
AU Ha, J
   Choi, DW
   Kim, KJ
   Cho, SY
   Kim, H
   Kim, KY
   Koh, Y
   Nam, CM
   Kim, E
AF Ha, Junghee
   Choi, Dong-Woo
   Kim, Kwang Joon
   Cho, So Yeon
   Kim, Hyunjeong
   Kim, Keun You
   Koh, Youngseung
   Nam, Chung Mo
   Kim, Eosu
TI Association of metformin use with Alzheimer's disease in patients with
   newly diagnosed type 2 diabetes: a population-based nested case-control
   study
SO SCIENTIFIC REPORTS
LA English
DT Article
ID ACTIVATED PROTEIN-KINASE; COGNITIVE DECLINE; RISK-FACTOR; DEMENTIA;
   DEPRESSION; MEMORY; BRAIN
AB Metformin reduces insulin resistance, which constitutes a pathophysiological connection of diabetes with Alzheimer's disease (AD), but the evidence of metformin on AD development was still insufficient and conflicting. We investigated AD risk in patients with newly diagnosed type 2 DM treated with metformin. This retrospective, observational, nested case-control study included patients with newly diagnosed type 2 DM obtained from the Korean National Health Insurance Service DM cohort (2002-2017). Among 70,499 dementia-free DM patients, 1675 AD cases were matched to 8375 controls for age, sex, and DM onset and duration. The association between AD and metformin was analyzed by multivariable regression analyses, adjusted for comorbidities and cardiometabolic risk profile. Metformin use was associated with an increased odds of AD (adjusted odds ratio [AOR] 1.50; 95% CI 1.23-1.83). The risk of AD was higher in patients with a longer DM duration. Furthermore, AD risk was significantly high in DM patients with depression (AOR 2.05; 95% CI 1.02-4.12). Given the large number of patients with DM who are taking metformin worldwide, a double-blinded, prospective study is required to determine the long-term cognitive safety of metformin.
C1 [Ha, Junghee; Cho, So Yeon; Kim, Hyunjeong; Kim, Keun You; Kim, Eosu] Yonsei Univ, Coll Med, Inst Behav Sci Med, Dept Psychiat, 50-1 Yonsei Ro, Seoul 03722, South Korea.
   [Choi, Dong-Woo] Natl Canc Ctr, Canc Big Data Ctr, Natl Canc Control Inst, Gyeonggi Do, South Korea.
   [Kim, Kwang Joon] Yonsei Univ, Coll Med, Dept Internal Med, Div Geriatr, Seoul, South Korea.
   [Cho, So Yeon; Kim, Eosu] Yonsei Univ, Coll Med, Brain Korea 21 FOUR Project Med Sci, Seoul, South Korea.
   [Koh, Youngseung] Yonsei Univ, Dept Med, Coll Med, Seoul, South Korea.
   [Nam, Chung Mo] Yonsei Univ, Coll Med, Dept Prevent Med, 50-1 Yonsei Ro, Seoul 03722, South Korea.
C3 Yonsei University; Yonsei University Health System; National Cancer
   Center - Korea (NCC); Yonsei University; Yonsei University Health
   System; Yonsei University; Yonsei University Health System; Yonsei
   University; Yonsei University Health System; Yonsei University; Yonsei
   University Health System
RP Kim, E (corresponding author), Yonsei Univ, Coll Med, Inst Behav Sci Med, Dept Psychiat, 50-1 Yonsei Ro, Seoul 03722, South Korea.; Kim, E (corresponding author), Yonsei Univ, Coll Med, Brain Korea 21 FOUR Project Med Sci, Seoul, South Korea.; Nam, CM (corresponding author), Yonsei Univ, Coll Med, Dept Prevent Med, 50-1 Yonsei Ro, Seoul 03722, South Korea.
EM cmnam@yuhs.ac; eosu.kim@yonsei.ac.kr
RI ; Kim, Keun You/ITW-0312-2023
OI Nam, Chung Mo/0000-0003-0985-0928; Ha, Junghee/0000-0002-4217-3570; Kim,
   Keun You/0000-0001-7192-2828; Kim, Eosu/0000-0001-9472-9465; Choi,
   Dong-Woo/0000-0001-5462-7579
FU Korean Association for Geriatric Psychiatry; Yonsei University College
   of Medicine [6-2018-0171]
FX This study was supported by a research grant from the Korean Association
   for Geriatric Psychiatry and a Faculty Research Grant from Yonsei
   University College of Medicine (6-2018-0171).
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NR 40
TC 43
Z9 44
U1 1
U2 12
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD DEC 15
PY 2021
VL 11
IS 1
AR 24069
DI 10.1038/s41598-021-03406-5
PG 9
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Science & Technology - Other Topics
GA XP2ZU
UT WOS:000730739800015
PM 34912022
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Marshe, VS
   Pira, S
   Mantere, O
   Bosche, B
   Looper, KJ
   Herrmann, N
   Müller, DJ
   Rej, S
AF Marshe, Victoria S.
   Pira, Shamira
   Mantere, Outi
   Bosche, Bert
   Looper, Karl J.
   Herrmann, Nathan
   Mueller, Daniel J.
   Rej, Soham
TI C-reactive protein and cardiovascular risk in bipolar disorder patients:
   A systematic review
SO PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
LA English
DT Review
DE Bipolar disorder; Cardiovascular disease; Cardiovascular risk factors;
   C-reactive protein; Inflammation; Metabolic syndrome; Review
ID MAJOR DEPRESSIVE DISORDER; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   UNIPOLAR DEPRESSION; SEDENTARY BEHAVIOR; PHYSICAL-ACTIVITY; MOOD
   STABILIZERS; CYTOKINE LEVELS; OLDER-ADULTS; DISEASE
AB Objectives: New research is revealing a strong association between inflammatory markers with bipolar disorder (BD), potentially due to the high prevalence of cardiovascular disease and cardiovascular risk factors in BD. We aimed to synthesize the literature examining the association between the clinically most relevant inflammatory marker, C-reactive protein (CRP) and cardiovascular disease and cardiovascular risk factors in patients with BD.
   Methods: MEDLINE, Embase and PsychInfo were systematically searched for all relevant English language articles published prior to April 2017. Articles were included if they examined the association between CRP and cardiovascular risk factors/disease in BD.
   Results: Fifteen relevant articles were retrieved. Studies were mostly cross-sectional and heterogeneous in the cardiovascular risk factors investigated. Overall, elevated CRP was associated with increased risk of metabolic syndrome, elevated body mass index, higher waist circumference, and obesity. CRP was inconsistently associated with elevated fasting glucose, insulin levels, serum triglycerides, total cholesterol levels, and low high density lipoprotein (HDL) levels. Atypical antipsychotic use may mediate some of these effects. No study examined CRP's association with actual cardiovascular disease (e. g. coronary artery disease) in BD.
   Conclusions: In BD, CRP is associated with increases in several cardiovascular risk factors, suggesting that systemic inflammation could be a shared driving force for both outcomes of BD and cardiovascular risk. Further longitudinal research is needed in this area to verify causality, including an examination of actual cardiovascular disease. Non-pharmacological and pharmacological treatments with anti-inflammatory effects should also be investigated, particularly in patients with increased CRP, for their potential to reduce cardiovascular risk in BD.
C1 [Marshe, Victoria S.; Mueller, Daniel J.] Univ Toronto, Inst Med Sci, Fac Med, Toronto, ON, Canada.
   [Marshe, Victoria S.; Mueller, Daniel J.] Ctr Addict & Mental Hlth, Campbell Family Mental Hlth Inst, Pharmacogenet Res Clin, Toronto, ON, Canada.
   [Pira, Shamira; Looper, Karl J.; Rej, Soham] Jewish Gen Hosp, Geri PARTy Res Grp, Montreal, PQ, Canada.
   [Mantere, Outi; Looper, Karl J.; Rej, Soham] McGill Univ, Dept Psychiat, Montreal, PQ, Canada.
   [Mantere, Outi] Douglas Mental Hlth Univ Inst, Bipolar Disorders Clin, Montreal, PQ, Canada.
   [Bosche, Bert] St Michaels Hosp, Div Neurosurg, Toronto, ON, Canada.
   [Bosche, Bert] Univ Toronto, St Michaels Hosp, Li Ka Shing Knowledge Inst, Neurosci Res Program,Keenan Res Ctr, Toronto, ON, Canada.
   [Bosche, Bert] Univ Toronto, Dept Surg, Toronto, ON, Canada.
   [Bosche, Bert] Univ Duisburg Essen, Univ Hosp Essen, Dept Neurol, Essen, Germany.
   [Herrmann, Nathan] Sunnybrook Hlth Sci Ctr, Neuropsychopharmacol Res Grp, Toronto, ON, Canada.
   [Mueller, Daniel J.] Univ Toronto, Dept Psychiat, Toronto, ON, Canada.
C3 University of Toronto; University of Toronto; Centre for Addiction &
   Mental Health - Canada; Jewish General Hospital - Montreal; McGill
   University; University of Toronto; Saint Michaels Hospital Toronto;
   University of Toronto; Saint Michaels Hospital Toronto; Li Ka Shing
   Knowledge Institute; University of Toronto; University of Duisburg
   Essen; University of Toronto; Sunnybrook Health Science Center;
   Sunnybrook Research Institute; University of Toronto
RP Rej, S (corresponding author), Jewish Gen Hosp, 4333 Cote Ste Catherine Rm 106, Montreal, PQ H3T 1E4, Canada.
EM soham.rej@mail.mcgill.ca
RI Bosche, Bert/AAB-7150-2020; Mueller, Daniel/GVT-7899-2022; Linnaranta
   (prev. Mantere), Outi/J-8524-2019; Mueller, Daniel/L-4159-2016
OI Bosche, Bert/0000-0002-5313-3195; Linnaranta (prev. Mantere),
   Outi/0000-0002-0383-7215; Mueller, Daniel/0000-0003-4978-4400
FU Canadian Institutes of Health Research Fellowship Award; Deutsche
   Forschungsgemeinschaft (DFG) [BO 4229/1-1, BO 4229/2-1]
FX Dr. Rej was funded by the Canadian Institutes of Health Research
   Fellowship Award. Dr. Bosche was supported by grants of the Deutsche
   Forschungsgemeinschaft (DFG; BO 4229/1-1, BO 4229/2-1).
CR [Anonymous], GENETIC RELATIONSHIP
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NR 85
TC 28
Z9 30
U1 0
U2 7
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0278-5846
EI 1878-4216
J9 PROG NEURO-PSYCHOPH
JI Prog. Neuro-Psychopharmacol. Biol. Psychiatry
PD OCT 3
PY 2017
VL 79
BP 442
EP 451
DI 10.1016/j.pnpbp.2017.07.026
PN B
PG 10
WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA FK0BR
UT WOS:000413145700042
PM 28764912
DA 2025-06-11
ER

PT J
AU Kumar, A
   Narayanaswamy, JC
   Venkatasubramanian, G
   Raguram, R
   Grover, S
   Aswath, M
AF Kumar, Ajay
   Narayanaswamy, Janardhanan C.
   Venkatasubramanian, G.
   Raguram, R.
   Grover, Sandeep
   Aswath, Manju
TI Prevalence of metabolic syndrome and its clinical correlates among
   patients with bipolar disorder
SO ASIAN JOURNAL OF PSYCHIATRY
LA English
DT Article
DE Metabolic syndrome; Bipolar disorder; Correlates; Prevalence
ID NATIONAL EPIDEMIOLOGIC SURVEY; CARDIOVASCULAR RISK-FACTORS;
   PHYSICAL-ACTIVITY; RATING-SCALE; NORTH-INDIA; ALCOHOL; OBESITY;
   SCHIZOPHRENIA; DEPENDENCE; MORTALITY
AB Objective: To assess the prevalence of metabolic syndrome (MetS) in patients with bipolar disorder (BD) and examine the clinical correlates of MetS.
   Methods: Sixty-seven patients with BD were evaluated for presence for MetS. The consensus definition was used to define MetS. The clinical variables were recorded on the basis of information provided by the patients, accompanying caregivers and review of treatment records. The symptoms severity of present depressive and manic episode was assessed by using Hamilton Depression Rating Scale (HDRS) and Young Mania Rating Scale (YMRS) respectively.
   Results: The prevalence of MetS was 53.7%. Patients with MetS were older than the patients with BD alone (P=0.001). Increased waist circumference was the most common abnormal parameter (74.6%) followed by low high density lipoprotein (HDL) (71.6%) and raised triglycerides (64.2%). High blood pressures were recorded in 35.8% with high fasting blood glucose levels were seen in 33.3%. MetS was associated with greater number of life time episodes (p=0.010), longer duration of illness (p=0.010), greater numbers of lifetime depressive episodes (p < 0.001). Substance use (alcohol and nicotine) associated with significantly higher prevalence of high blood pressure among MetS patients (p < 0.001) while abnormal triglyceride level shown associated with substance use (p=0.010). Age of the patients, number of lifetime depressive episodes and use of Olanzapine were found to predictive of the development of MetS.
   Conclusions: Patients with BD have high prevalence of MetS and its presence correlates with clinical variables. (C) 2017 Elsevier B.V. All rights reserved.
C1 [Kumar, Ajay; Grover, Sandeep] PGIMER, Dept Psychiat, Chandigarh, India.
   [Narayanaswamy, Janardhanan C.; Venkatasubramanian, G.] NIMHANS, Dept Psychiat, Bangalore, Karnataka, India.
   [Raguram, R.; Aswath, Manju] KIMS, Bangalore, Karnataka, India.
C3 Post Graduate Institute of Medical Education & Research (PGIMER),
   Chandigarh; National Institute of Mental Health & Neurosciences - India;
   Kempegowda Institute of Medical Sciences (KIMS)
RP Kumar, A (corresponding author), PGIMER, Dept Psychiat, Chandigarh, India.
EM ak_pal2000@yahoo.com; jairamnimhans@gmail.com; venkat.nimhans@yahoo.com;
   profraguram@gmal.com; drsandeepg2002@yahoo.com; manjuaswath@yahoo.com
RI Venkatasubramanian, Ganesan/AAD-9117-2019; Kumar, Dr Ajay/AAG-4580-2020
OI Venkatasubramanian, Ganesan/0000-0002-0949-898X; Kumar, Dr
   Ajay/0000-0003-0391-3836; Grover, Sandeep/0000-0002-2714-2055
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NR 30
TC 17
Z9 20
U1 0
U2 3
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1876-2018
EI 1876-2026
J9 ASIAN J PSYCHIATR
JI Asian J. Psychiatr.
PD APR
PY 2017
VL 26
BP 109
EP 114
DI 10.1016/j.ajp.2017.01.020
PG 6
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychiatry
GA EY8ZO
UT WOS:000404288300026
PM 28483070
DA 2025-06-11
ER

PT J
AU Mirahmadi, M
   Aghasizadeh, M
   Nazifkar, F
   Choubdari, MG
   Assaran-Darban, R
   Tavallaie, S
   Hatamzadeh, H
   Ferns, GA
   Mirinezhad, MR
   Baharara, H
   Hadizadeh, F
   Ghayour-Mobarhan, M
AF Mirahmadi, Mahdi
   Aghasizadeh, Malihe
   Nazifkar, Fatemeh
   Choubdari, Mahla Ghafarian
   Assaran-Darban, Reza
   Tavallaie, Shima
   Hatamzadeh, Hossein
   Ferns, Gordon A.
   Mirinezhad, Mohammad Reza
   Baharara, Hamed
   Hadizadeh, Farzin
   Ghayour-Mobarhan, Majid
TI The Effects of Lycopene on Modulating Oxidative Stress and Liver Enzymes
   Levels in Metabolic Syndrome Patients: A Randomised Clinical Trial
SO CELL JOURNAL
LA English
DT Article
DE Inflammation; Liver Enzyme; Lycopene; Metabolic Syndrome; Oxidative
   Stress
ID TOMATO; DISEASE; ANTIOXIDANT; EXTRACTION
AB Objective: The pathogenesis of metabolic syndrome (MetS) complications involves the excessive production of reactive oxygen species, inflammation, and endothelial dysfunction. Due to Lycopene, a highly unstable structure and its significant effects on modulating the metabolic system, there is a strong need for a formula that can increase its stability. The aim of this study was to develop an approach for encapsulating Lycopene and investigate its effects on inflammatory markers, oxidative stress, and liver enzymes in patients with MetS.Materials and Methods: This study is a simple randomized, double-blind, objective-based clinical trial that involved eighty subjects with MetS, who were equally and randomly assigned to two groups: one group received 20 mg of Lycopene per day for 8 weeks, and the Placebo group followed the same protocol as the Lycopene group but received a placebo instead of Lycopene. They were called Lycopene and placebo, respectively. During follow-up visits after 4 and 8 weeks, 20 ml of blood was collected for evaluation of liver enzymes and some inflammatory related markers.Results: Prior to the assignment of volunteers to their respective groups, there were no notable differences in C-reactive protein (CRP), serum liver enzymes, systolic and diastolic blood pressure, or pro-oxidant-antioxidant balance (PAB) between the Lycopene and placebo groups. However, our subsequent analysis revealed a significant reduction in the serum levels of CRP (P=0.001) and PAB (P=0.004) in the group that received Lycopene. Our encapsulated Lycopene treatment was not associated with a significant difference in serum levels of alanine aminotransferase (ALT), aspartate transferase (AST), or alkaline phosphatase (ALP) between our two groups.Conclusion: This study investigated the impact of Lycopene on individuals with MetS, revealing a noteworthy modulation effect on PAB and inflammation linked to MetS. However, no significant differences was demonstrated in serum levels of ALT, AST and ALP between the studied group (registration number: IRCT20130507013263N3).
C1 [Mirahmadi, Mahdi; Hadizadeh, Farzin] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Biotechnol Res Ctr, POB 99199-91766, Mashhad, Iran.
   [Aghasizadeh, Malihe; Tavallaie, Shima; Ghayour-Mobarhan, Majid] Mashhad Univ Med Sci, Int UNESCO Ctr Hlth Related Basic Sci & Human Nutr, POB 99199-91766, Mashhad, Iran.
   [Nazifkar, Fatemeh; Choubdari, Mahla Ghafarian; Assaran-Darban, Reza] Islamic Azad Univ, Dept Biol, Mashhad Branch, Mashhad, Iran.
   [Hatamzadeh, Hossein] Mashhad Univ Med Sci, Fac Med, Dept Nutr, Mashhad, Iran.
   [Ferns, Gordon A.] Brighton & Sussex Med Sch, Div Med Educ, Brighton, England.
   [Mirinezhad, Mohammad Reza] Mashhad Univ Med Sci, Fac Med, Dept Med Genet, Mashhad, Iran.
   [Baharara, Hamed] Mashhad Univ Med Sci, Sch Pharm, Dept Clin Pharm, Mashhad, Iran.
   [Hadizadeh, Farzin] Mashhad Univ Med Sci, Sch Pharm, Dept Med Chem, Mashhad, Iran.
C3 Mashhad University of Medical Sciences; Mashhad University of Medical
   Sciences; Islamic Azad University; Mashhad University of Medical
   Sciences; University of Brighton; University of Sussex; Mashhad
   University of Medical Sciences; Mashhad University of Medical Sciences;
   Mashhad University of Medical Sciences
RP Hadizadeh, F (corresponding author), Mashhad Univ Med Sci, Pharmaceut Technol Inst, Biotechnol Res Ctr, POB 99199-91766, Mashhad, Iran.; Ghayour-Mobarhan, M (corresponding author), Mashhad Univ Med Sci, Int UNESCO Ctr Hlth Related Basic Sci & Human Nutr, POB 99199-91766, Mashhad, Iran.
EM hadizadehf@mums.ac.ir; ghayourm@mums.ac.ir
RI Ghayour-Mobarhan, Majid/AAY-5963-2020; Hadizadeh, Farzin/AAG-2067-2019;
   Assaran Draban, Reza/S-3572-2017
OI Aghasizadeh, Malihe/0000-0001-8562-360X
FU Mashhad University of Medical Sciences [960774]
FX This project was implemented in collaboration with Mashhad University of
   Medical Sciences (grant number: 960774). The authors would like to
   gratefully acknowledge the contribution of participants in the study.
   The authors declare that they have no conflicts of interest in this
   study
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NR 38
TC 8
Z9 8
U1 0
U2 0
PU ROYAN INST
PI TEHRAN
PA PO BOX 19395-4644, TEHRAN, 00000, IRAN
SN 2228-5806
EI 2228-5814
J9 CELL J
JI Cell J.
PD DEC
PY 2023
VL 25
IS 12
BP 847
EP 853
DI 10.22074/CELLJ.2023.2006158.1353
PG 7
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA FI1R2
UT WOS:001145046200007
PM 38192255
DA 2025-06-11
ER

PT J
AU Hayden, MR
   Yang, Y
   Habibi, J
   Bagree, SV
   Sowers, JR
AF Hayden, Melvin R.
   Yang, Ying
   Habibi, Javad
   Bagree, Sarika V.
   Sowers, James R.
TI Pericytopathy Oxidative stress and impaired cellular longevity in the
   pancreas and skeletal muscle in metabolic syndrome and type 2 diabetes
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Review
DE adult mesenchymal stem cells; antipericyte autoantibodies; apoptosis;
   beta cells; islet amyloid; islet fibrosis; rarefaction; reactive oxygen
   species
ID GLYCATION END-PRODUCTS; MESENCHYMAL STEM-CELLS; HIP RAT MODEL;
   INSULIN-RESISTANCE; MICROVASCULAR PERICYTES; INTRAMURAL PERICYTES;
   ELECTRON-MICROSCOPY; VASCULAR-DISEASE; MELLITUS; RETINOPATHY
AB The pericyte's role has been extensively studied in retinal tissues of diabetic retinopathy; however, little is known regarding its role in such tissues as the pancreas and skeletal muscle. This supportive microvascular mural cell plays an important and novel role in cellular and extracellular matrix remodeling in the pancreas and skeletal muscle of young rodent models representing the metabolic syndrome and type 2 diabetes mellitus (T2DM). Transmission electron microscopy can be used to evaluate these tissues from young rodent models of insulin resistance and T2DM, including the transgenic Ren2 rat, db/db obese insulin resistant-T2DM mouse, and human islet amyloid polypeptide (HIP) rat model of T2DM. With this method, the earliest pancreatic remodeling change was widening of the islet exocrine interface and pericyte hypercellularity, followed by pericyte differentiation into islet and pancreatic stellate cells with early fibrosis involving the islet exocrine interface and interlobular interstitium. In skeletal muscle there was a unique endothelial capillary connectivity via elongated longitudinal pericyte processes in addition to pericyte to pericyte and pericyte to myocyte cell-cell connections allowing for paracrine communication. Initial pericyte activation due to moderate oxidative stress signaling may be followed by hyperplasia, migration and differentiation into adult mesenchymal cells. Continued robust oxidative stress may induce pericyte apoptosis and impaired cellular longevity. Circulating antipericyte autoantibodies have recently been characterized, and may provide a screening method to detect those patients who are developing pericyte loss and are at greater risk for the development of complications of T2DM due to pericytopathy and rarefaction. Once detected, these patients may be offered more aggressive treatment strategies such as early pharmacotherapy in addition to lifestyle changes targeted to maintaining pericyte integrity. In conclusion, we have provided a review of current knowledge regarding the pericyte and novel ultrastructural findings regarding its role in metabolic syndrome and T2DM.
C1 [Hayden, Melvin R.; Yang, Ying; Habibi, Javad; Sowers, James R.] Univ Missouri, Sch Med, Dept Internal Med, Kunming, Peoples R China.
   [Sowers, James R.] Yunnan Prov 2nd Hosp, Dept Physiol, Kunming, Peoples R China.
   [Yang, Ying; Habibi, Javad; Sowers, James R.] Yunnan Prov 2nd Hosp, Dept Pharmacol, Kunming, Peoples R China.
   [Hayden, Melvin R.; Yang, Ying; Habibi, Javad; Bagree, Sarika V.; Sowers, James R.] Yunnan Prov 2nd Hosp, Harry S Truman VA Med Ctr, Kunming, Peoples R China.
   [Yang, Ying] Yunnan Prov 2nd Hosp, Diabet Cardiovasc Ctr, Kunming, Peoples R China.
RP Hayden, MR (corresponding author), Univ Missouri, Sch Med, Dept Internal Med, Kunming, Peoples R China.
EM mrh29@usmo.com
FU NIH [R01 HL73101-01A1]; Veterans Affairs Merit System [0018]
FX This research was supported by NIH (R01 HL73101-01A1), Veterans Affairs
   Merit System 0018 (J.R.S.).
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NR 59
TC 37
Z9 42
U1 3
U2 10
PU HINDAWI PUBLISHING CORPORATION
PI NEW YORK
PA 410 PARK AVENUE, 15TH FLOOR, #287 PMB, NEW YORK, NY 10022 USA
SN 1942-0900
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PD SEP-OCT
PY 2010
VL 3
IS 5
BP 290
EP 303
DI 10.4161/oxim.3.5.13653
PG 14
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA 716TI
UT WOS:000286996000002
PM 21150342
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Sadabadi, F
   Darroudi, S
   Esmaily, H
   Asadi, Z
   Ferns, GA
   Mohammadpour, AH
   Nooriyan, AH
   Ghayour-Mobarhan, M
   Moohebati, M
AF Sadabadi, Fatemeh
   Darroudi, Susan
   Esmaily, Habibollah
   Asadi, Zahra
   Ferns, Gordon A.
   Mohammadpour, Amir Hooshang
   Nooriyan, Amir Hossein
   Ghayour-Mobarhan, Majid
   Moohebati, Mohsen
TI The importance of sleep patterns in the incidence of coronary heart
   disease: a 6-year prospective study in Mashhad, Iran
SO SCIENTIFIC REPORTS
LA English
DT Article
ID CARDIOVASCULAR-DISEASE; INSOMNIA SYMPTOMS; RISK; DURATION; METAANALYSIS;
   ASSOCIATION; MASHAD
AB Chronic shortened sleep can increase several cardiovascular risk factors, including depression, anxiety, metabolic syndrome, diabetes and hypertension. In the current study, we aimed to investigate the relationship between sleep patterns and the incidence of coronary heart disease (CHD). A total of 9704 healthy participants were recruited for the MASHAD cohort study. Within 6 years of follow-up, participants were categorized into four groups based on their number of hours of nightly sleep. Cox's proportional hazard model was used to assess relative risks (RRs) and 95% confidence intervals (CIs). During the study, 235 heart problems, including myocardial infarction, stable angina and unstable angina, were confirmed. There were significant differences between men and women who had short and long nightly sleep (p < 0.05). The incidence of CHD was significantly higher in participants with very short night sleep durations than in those with longer hours of night sleep. The subjects with very short nightly sleep were more susceptible to unstable angina (RR: 2.614 (CI 1.354-5.047)) (p < 0.05). We found that shortened nightly sleep was associated with an increased incidence of coronary heart disease in an Iranian population. These findings suggest that sleep disorders, especially shortened night sleep, can be a risk factor for CHD.
C1 [Sadabadi, Fatemeh; Darroudi, Susan; Asadi, Zahra; Ghayour-Mobarhan, Majid] Mashhad Univ Med Sci, Int UNESCO Ctr Hlth, Related Basic Sci & Human Nutr, Mashhad, Iran.
   [Esmaily, Habibollah] Mashhad Univ Med Sci, Social Determinants Hlth Res Ctr, Mashhad, Iran.
   [Ferns, Gordon A.] Brighton & Sussex Med Sch, Div Med Educ, Falmer, Brighton BN1 9PH, Sussex, England.
   [Mohammadpour, Amir Hooshang] Mashhad Univ Med Sci, Pharmaceut Inst Technol, Pharmaceut Res Ctr, Mashhad, Iran.
   [Mohammadpour, Amir Hooshang] Mashhad Univ Med Sci, Sch Pharm, Dept Clin Pharm, Mashhad, Iran.
   [Nooriyan, Amir Hossein] Islamic Azad Univ Mashhad, Mashhad, Iran.
   [Ghayour-Mobarhan, Majid] Mashhad Univ Med Sci, Metab Syndrome Res Ctr, Sch Med, Mashhad 9919991766, Iran.
   [Moohebati, Mohsen] Mashhad Univ Med Sci, Cardiovasc Res Ctr, Sch Med, Mashhad, Iran.
C3 Mashhad University of Medical Sciences; Mashhad University of Medical
   Sciences; University of Brighton; University of Sussex; Mashhad
   University of Medical Sciences; Mashhad University of Medical Sciences;
   Islamic Azad University; Mashhad University of Medical Sciences; Mashhad
   University of Medical Sciences
RP Ghayour-Mobarhan, M (corresponding author), Mashhad Univ Med Sci, Int UNESCO Ctr Hlth, Related Basic Sci & Human Nutr, Mashhad, Iran.; Ghayour-Mobarhan, M (corresponding author), Mashhad Univ Med Sci, Metab Syndrome Res Ctr, Sch Med, Mashhad 9919991766, Iran.; Moohebati, M (corresponding author), Mashhad Univ Med Sci, Cardiovasc Res Ctr, Sch Med, Mashhad, Iran.
EM ghayourm@mums.ac.ir; mouhebatim@mums.ac.ir
RI Ghayour-Mobarhan, Majid/AAY-5963-2020; mohebati, mohsen/AAR-2016-2021
CR Baglioni C, 2011, J AFFECT DISORDERS, V135, P10, DOI 10.1016/j.jad.2011.01.011
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NR 31
TC 3
Z9 3
U1 0
U2 6
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD FEB 18
PY 2023
VL 13
IS 1
AR 2903
DI 10.1038/s41598-023-29451-w
PG 8
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 9S9NK
UT WOS:000946661900025
PM 36806201
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Narbutt, J
   Niedzwiedz, M
   Lesiak, A
   Ceryn, J
   Skibinska, M
AF Narbutt, Joanna
   Niedzwiedz, Michal
   Lesiak, Aleksandra
   Ceryn, Justyna
   Skibinska, Malgorzata
TI Secukinumab for the Treatment of Psoriasis in Pediatrics: Patient
   Selection and Acceptability
SO PATIENT PREFERENCE AND ADHERENCE
LA English
DT Review
DE pediatric psoriasis; psoriasis vulgaris; secukinumab; acceptability
ID SYSTEMIC TREATMENT; ATOPIC-DERMATITIS; EXPERIENCE; MANAGEMENT; DISEASES;
   INDEX; IL-17
AB Psoriasis (PsO) is a chronic, systemic, immune-mediated inflammatory skin disease affecting 1% to 5% population worldwide. In one-third of patients, the first symptoms of PsO manifest in childhood, with a mean age of nine years. Psoriasis in children under 16 years of age constitutes 4% of dermatological problems in this age group. Chronic inflammation of the skin observed in PsO is associated with a development of potentially serious comorbidities, including psoriatic arthritis, hypertension, metabolic syndrome, cardiovascular diseases, inflammatory bowel disease, depression and anxiety. It is reported that among children with psoriasis between 5 and 16 years of age health-related quality of life is reduced by 30.5%. Early diagnosis and effective treatment are crucial in pediatric psoriatic patients to avoid future complications and stigmatization. Treatment for psoriasis consists of a range of topical medications, phototherapy and non-biologic and biologic systemic therapies. Approved biologics for PsO in pediatric patients include etanercept, adalimumab, ustekinumab, ixekizumab and secukinumab. Secukinumab, a recombinant, fully human monoclonal antibody targeting IL-17A, was approved by the EMA (2020) and FDA (2021) in pediatric patients above 6 years of age for the treatment of moderate to severe plaque psoriasis who are candidates for systemic therapy. This review discusses the selection and acceptability of secukinumab in children with psoriasis.
C1 [Narbutt, Joanna; Niedzwiedz, Michal; Lesiak, Aleksandra; Ceryn, Justyna; Skibinska, Malgorzata] Med Univ Lodz, Dept Dermatol Pediat Dermatol & Dermatol Oncol, Lodz, Poland.
   [Ceryn, Justyna] Med Univ Lodz, Int Doctoral Sch, Lodz, Poland.
   [Niedzwiedz, Michal] Med Univ Lodz, Dept Dermatol Pediat Dermatol & Oncol, Gen Karola Kniaziewicza 1-5, PL-91347 Lodz, Poland.
C3 Medical University Lodz; Medical University Lodz; Medical University
   Lodz
RP Niedzwiedz, M (corresponding author), Med Univ Lodz, Dept Dermatol Pediat Dermatol & Dermatol Oncol, Lodz, Poland.; Niedzwiedz, M (corresponding author), Med Univ Lodz, Dept Dermatol Pediat Dermatol & Oncol, Gen Karola Kniaziewicza 1-5, PL-91347 Lodz, Poland.
EM michal.niedzwiedz@umed.lodz.pl
RI Niedźwiedź, Michał/KBA-4159-2024; Lesiak, Aleksandra/S-9634-2016;
   Niedzwiedz, Michal/GRY-6089-2022
OI Niedzwiedz, Michal/0000-0002-9322-629X; Skibinska,
   Malgorzata/0000-0001-9264-5751; Ceryn, Justyna/0000-0001-8969-6814;
   Lesiak, Aleksandra/0000-0003-3318-729X
FU  [503/5-064-04/503-01]
FX Funding This research was funded by statutory activity no.
   503/5-064-04/503-01 (Medical University of Lodz) .
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NR 71
TC 7
Z9 8
U1 2
U2 19
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1177-889X
J9 PATIENT PREFER ADHER
JI Patient Prefer. Adherence
PY 2023
VL 17
BP 421
EP 431
DI 10.2147/PPA.S350753
PG 11
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA C8PM4
UT WOS:000964473200001
PM 36815128
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Scott, D
   Burke, K
   Williams, S
   Happell, B
   Canoy, D
   Ronan, K
AF Scott, David
   Burke, Karena
   Williams, Susan
   Happell, Brenda
   Canoy, Doreen
   Ronan, Kevin
TI Increased prevalence of chronic physical health disorders in Australians
   with diagnosed mental illness
SO AUSTRALIAN AND NEW ZEALAND JOURNAL OF PUBLIC HEALTH
LA English
DT Article
DE mental disorders; chronic disease; obesity; comorbidity
ID METABOLIC SYNDROME; PEOPLE; SCHIZOPHRENIA; DEPRESSION; MORTALITY;
   DISEASE; ANXIETY; CANCER; DEATH; RISK
AB Objective: To compare chronic physical health disorder prevalence amongst Australian adults with and without mental illness. Method: Total n=1,716 participants (58% female) with a mean age of 52 +/- 13 years (range: 18 to 89 years) completed an online survey of Australian adults in 2010. Outcome measures including prevalence of chronic physical conditions and self-reported body mass index (BMI) in n=387 (23%) with a self-reported mental illness diagnosis were compared to respondents without mental illness. Results: A significantly higher proportion of participants with mental illness were obese (BMI = 30; 31 vs 24%, p=0.005). Adjusted odds ratios (OR) for coronary heart disease, diabetes, chronic bronchitis or emphysema, asthma, irritable bowel syndrome, and food allergies or intolerances (OR range: 1.543.19) demonstrated that chronic physical disorders were significantly more common in participants with a mental illness. Conclusion: Australian adults with a diagnosis for mental illness have a significantly increased likelihood of demonstrating chronic physical health disorders compared to persons without mental illness. Implications: Health professionals must be alert to the increased likelihood of comorbid chronic physical disorders in persons with a mental illness and should consider the adoption of holistic approaches when treating those with either a mental or physical illness.
C1 [Scott, David; Burke, Karena; Williams, Susan; Happell, Brenda; Canoy, Doreen; Ronan, Kevin] CQUniv, Inst Hlth & Social Sci Res, Rockhampton, Qld 4702, Australia.
C3 Central Queensland University
RP Scott, D (corresponding author), CQUniv, Inst Hlth & Social Sci Res, Bldg 18, Rockhampton, Qld 4702, Australia.
EM d.scott@cqu.edu.au
RI Scott, David/AAE-5031-2021; Burke, Karena/ABG-2775-2020; Happell,
   Brenda/HSI-0570-2023
OI Happell, Brenda/0000-0002-7293-6583; Ronan, Kevin/0000-0002-2698-5886;
   Burke, Professor Karena J./0000-0002-3754-076X; Scott,
   David/0000-0001-5226-1972
CR [Anonymous], 2010, AUSTR HLTH 2010
   Australian Bureau of Statistics, 2008, 4326 0 NAT SURV MENT
   Australian Bureau of Statistics, 2009, 8146 0 HOUS US INF T, P2008
   Australian Bureau of Statistics, 2006, CENS 2006
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NR 20
TC 27
Z9 28
U1 0
U2 42
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1326-0200
EI 1753-6405
J9 AUST NZ J PUBL HEAL
JI Aust. N. Z. Publ. Health
PD OCT
PY 2012
VL 36
IS 5
BP 483
EP 486
DI 10.1111/j.1753-6405.2012.00916.x
PG 4
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA 014XN
UT WOS:000309409200017
PM 23025372
OA Bronze
DA 2025-06-11
ER

PT J
AU Kakouri, NS
   Thomopoulos, CG
   Siafi, EP
   Valatsou, AE
   Dimitriadis, KS
   Mani, IP
   Patsilinakos, SP
   Tousoulis, DM
   Tsioufis, KP
AF Kakouri, Niki S.
   Thomopoulos, Costas G.
   Siafi, Eirini P.
   Valatsou, Angeliki E.
   Dimitriadis, Kyriakos S.
   Mani, Iliana P.
   Patsilinakos, Sotirios P.
   Tousoulis, Dimitrios M.
   Tsioufis, Konstantinos P.
TI Overview of the Association Between Non-Alcoholic Fatty Liver Disease
   and Hypertension
SO CARDIOLOGY DISCOVERY
LA English
DT Review
DE Hypertension; Non-alcoholic fatty liver disease; Insulin resistance;
   Sympathetic nervous system; Metabolic syndrome
ID RENIN-ANGIOTENSIN SYSTEM; INSULIN-RESISTANCE; BLOOD-PRESSURE; FOLLOW-UP;
   STEATOHEPATITIS; FIBROSIS; OBESITY; RISK; INHIBITION; STEATOSIS
AB Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease, and its prevalence is rising. NAFLD is closely associated with metabolic syndrome, with both conditions sharing common clinical characteristics such as obesity, insulin resistance, type 2 diabetes mellitus, hypertension, and hypertriglyceridemia. Several observational studies have evaluated the relationship between NAFLD and hypertension, with the overall evidence suggesting a bidirectional relationship. It is hypothesized that activation of the sympathetic nervous and renin-angiotensin systems, observed in NAFLD with or without insulin resistance promotes the development of hypertension. In patients with hypertension, activation of these systems can lead to hepatic fibrosis and progressive inflammation through increased oxidative stress and activation of hepatic stellate cells and Kupffer cells. The present review examines the pathophysiologic and clinical evidence supporting the bidirectional association between NAFLD and hypertension.
C1 [Kakouri, Niki S.; Siafi, Eirini P.; Valatsou, Angeliki E.; Dimitriadis, Kyriakos S.; Mani, Iliana P.; Tousoulis, Dimitrios M.; Tsioufis, Konstantinos P.] Natl & Kapodistrian Univ Athens, Hippokrat Hosp, Med Sch, Dept Cardiol 1, Athens 11527, Greece.
   [Thomopoulos, Costas G.] Elena Venizelou Hosp, Dept Cardiol, Athens 11521, Greece.
   [Patsilinakos, Sotirios P.] Gen Hosp Agia Olga, Dept Cardiol, Athens 14233, Greece.
C3 National & Kapodistrian University of Athens; Hippokration General
   Hospital; General Hospital of N. Ionia Agia Olga
RP Tsioufis, KP (corresponding author), Natl & Kapodistrian Univ Athens, Hippokrat Hosp, Med Sch, Dept Cardiol 1, Athens 11527, Greece.
EM ktsioufis@hippocratio.gr
RI Thomopoulos, Costas/ABF-1156-2021
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NR 64
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 2096-952X
EI 2693-8499
J9 CARDIOL DISCOV
JI Cardiol. Discov.
PD MAR
PY 2024
VL 4
IS 1
BP 30
EP 37
DI 10.1097/CD9.0000000000000113
PG 8
WC Cardiac & Cardiovascular Systems
WE Emerging Sources Citation Index (ESCI)
SC Cardiovascular System & Cardiology
GA K2K9A
UT WOS:001342227800007
OA gold
DA 2025-06-11
ER

PT J
AU Xu, HY
   Zhuang, XY
AF Xu, Haiyun
   Zhuang, Xiaoyin
TI Atypical antipsychotics-induced metabolic syndrome and nonalcoholic
   fatty liver disease: a critical review
SO NEUROPSYCHIATRIC DISEASE AND TREATMENT
LA English
DT Review
DE antipsychotics; MetS; NAFLD; schizophrenia
ID INDUCED WEIGHT-GAIN; INDUCED HEPATIC STEATOSIS; OLANZAPINE TREATMENT;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; DOUBLE-BLIND;
   CARDIOVASCULAR-DISEASE; GLUCOSE-HOMEOSTASIS; ANTIOXIDANT ENZYMES;
   CLOZAPINE TREATMENT
AB The atypical antipsychotics (AAPs) have been used as first-line drugs in psychiatric practice for a wide range of psychotic disorders, including schizophrenia and bipolar mania While effectively exerting therapeutic effects on positive and negative symptoms, as well as cognitive impairments in schizophrenia patients, these drugs are less likely to induce extrapyramidal symptoms compared to typical antipsychotics. However, the increasing application of them has raised questions on their tolerability and adverse effects over the endocrine, metabolic, and cardiovascular axes. Specifically, AAPs are associated to different extents, with weight gain, metabolic syndrome (MetS), and nonalcoholic fatty liver disease (NAFLD). This article summarized clinical evidence showing the metabolic side effects of AAPs in patients with schizophrenia, and experimental evidence of AAPs-induced metabolic side effects observed in animals and cell culture studies. In addition, it discussed potential mechanisms involved in the APPs-induced MetS and NAFLD.
C1 [Xu, Haiyun; Zhuang, Xiaoyin] Shantou Univ, Med Coll, Mental Hlth Ctr, Shantou 515041, Peoples R China.
C3 Shantou University
RP Xu, HY (corresponding author), Shantou Univ, Med Coll, Mental Hlth Ctr, Shantou 515041, Peoples R China.
EM hyxu@stu.edu.cn
RI Xu, Haiyun/AFL-1251-2022; zhuang, xiaoyin/LRT-4619-2024
OI Xu, Haiyun/0000-0002-0752-6502; Zhuang, Xiaoyin/0000-0001-5172-260X
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NR 152
TC 49
Z9 51
U1 1
U2 22
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
EI 1178-2021
J9 NEUROPSYCH DIS TREAT
JI Neuropsychiatr. Dis. Treat.
PY 2019
VL 15
BP 2087
EP 2099
DI 10.2147/NDT.S208061
PG 13
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA IK8PW
UT WOS:000476858100001
PM 31413575
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Parsanathan, R
   Jain, SK
AF Parsanathan, Rajesh
   Jain, Sushil K.
TI Hydrogen sulfide regulates circadian-clock genes in
   C2C12 myotubes and the muscle of high-fat-diet-fed
   mice
SO ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
LA English
DT Article
DE Hydrogen sulfide (H2S); Glutathione (GSH); Oxidative stress (OS); Core
   clock genes (CCG)
ID TUMOR-NECROSIS-FACTOR; OXIDATIVE STRESS; TNF-ALPHA; RESPONSE ELEMENT;
   SKELETAL-MUSCLE; ADIPOSE-TISSUE; HEART-FAILURE; PLASMA-LEVELS;
   TRANSCRIPTION; EXPRESSION
AB Hydrogen sulfide (H2S) is an endogenous novel gasotransmitter which is implicated in the pathophysiology of the metabolic syndrome. Core clock genes (CCG) and its controlled genes disruption is implicated in the progression of metabolic syndrome. We examined whether H2S has any effect on CCG in the skeletal muscle of mice fed a high-fat diet (HFD) and in myotubes. In the muscle of HFD-mice, the expression of H2S biosynthesis enzyme genes (CSE, CBS, and 3-Mpst) along with antioxidant genes (GCLC, GCLM, GSS, and GSR) involved in GSH biosynthesis and recycling were reduced significantly, but the oxidative stress (OS) increased. Expression of the CCG (Bmal1, Clock, ROR alpha, Cry2, Per2) and clock-controlled genes (PPAR gamma, PGC-1 alpha, RXR alpha) was downregulated, whereas the levels of PPAR alpha mRNA were upregulated. Similar to that in the muscle of HFD-mice, in vitro myotubes exposed to high glucose or palmitate to mimic metabolic syndrome, showed an increased OS and decreased in CSE mRNA, H2S production and CCG mRNA levels were also downregulated. TNF and MCP-1 treatment on the myotubes was similar to that observed in HFD-muscle, with that the Rev-erba mRNA was upregulated. Inhibition (siRNA/pharmacological inhibitors) of both CSE and GCLC (the rate-limiting enzyme in GSH biosynthesis) decreased H2S, and increased OS; Bmal1 and Clock mRNA levels were downregulated, while Rev-erba increased significantly in these conditions. CSE KD myotubes were post-treated with an H2S donor partially restored the mRNA levels of core clock genes. These findings report that the deficiencies of H2S/GSH impair expression of CCG and treatment with H2S donor or GSH precursor exert a positive effect over CCG. Thus, suggest that H2S as a new endogenous factor for regulating circadian clock, and its donors could provide a novel chrono-pharmacological therapy to manage metabolic disorders.
C1 Louisiana State Univ, Hlth Sci Ctr Shreveport, Dept Pediat, 1501 Kings Highway, Shreveport, LA 71130 USA.
   Louisiana State Univ, Hlth Sci Ctr Shreveport, Ctr Cardiovasc Dis & Sci, 1501 Kings Highway, Shreveport, LA 71130 USA.
C3 Louisiana State University System; Louisiana State University Health
   Sciences Center at Shreveport; Louisiana State University System;
   Louisiana State University Health Sciences Center at Shreveport
RP Jain, SK (corresponding author), 1501 Kings Highway, Shreveport, LA 71130 USA.
EM sjain@lsuhsc.edu
RI Parsanathan, Rajesh/C-2635-2016
FU Malcolm W. Feist Cardiovascular Research Fellowship; Endowed Chair in
   Diabetes; Center for Cardiovascular Diseases and Sciences (CCDS);
   LSUHSC, Shreveport; National Institutes of Health/National Center for
   Complementary and Integrative Health [RO1 AT007442]
FX This study was supported by a Malcolm W. Feist Cardiovascular Research
   Fellowship to RP and the Endowed Chair in Diabetes to SKJ from the
   Center for Cardiovascular Diseases and Sciences (CCDS), LSUHSC,
   Shreveport, as well as grants to SKJ from the National Institutes of
   Health/National Center for Complementary and Integrative Health (RO1
   AT007442, 2013-16). We thank Ms. Paula Polk, Manager, and Dr. Wiola
   Luszczek, Research Specialist, at the Research Core Facility at
   Louisiana State University Health Sciences Center in Shreveport for
   their expert technical assistance. We also thank Mr. William E. McLean
   for lab assistance. The authors thank Ms. Georgia Morgan for excellent
   editing.
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NR 55
TC 16
Z9 18
U1 0
U2 14
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0003-9861
EI 1096-0384
J9 ARCH BIOCHEM BIOPHYS
JI Arch. Biochem. Biophys.
PD SEP 15
PY 2019
VL 672
AR 108054
DI 10.1016/j.abb.2019.07.019
PG 10
WC Biochemistry & Molecular Biology; Biophysics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics
GA LC6JI
UT WOS:000525439000004
PM 31351068
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Saltiel, AR
   Olefsky, JM
AF Saltiel, Alan R.
   Olefsky, Jerrold M.
TI Inflammatory mechanisms linking obesity and metabolic disease
SO JOURNAL OF CLINICAL INVESTIGATION
LA English
DT Review
ID INDUCED INSULIN-RESISTANCE; ENDOPLASMIC-RETICULUM STRESS;
   ADIPOSE-TISSUE; HOMEOSTASIS; MICE
AB There are currently over 1.9 billion people who are obese or overweight, leading to a rise in related health complications, including insulin resistance, type 2 diabetes, cardiovascular disease, liver disease, cancer, and neurodegeneration. The finding that obesity and metabolic disorder are accompanied by chronic low-grade inflammation has fundamentally changed our view of the underlying causes and progression of obesity and metabolic syndrome. We now know that an inflammatory program is activated early in adipose expansion and during chronic obesity, permanently skewing the immune system to a proinflammatory phenotype, and we are beginning to delineate the reciprocal influence of obesity and inflammation. Reviews in this series examine the activation of the innate and adaptive immune system in obesity; inflammation within diabetic islets, brain, liver, gut, and muscle; the role of inflammation in fibrosis and angiogenesis; the factors that contribute to the initiation of inflammation; and therapeutic approaches to modulate inflammation in the context of obesity and metabolic syndrome.
C1 [Saltiel, Alan R.; Olefsky, Jerrold M.] Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA.
C3 University of California System; University of California San Diego
EM asaltiel@ucsd.edu; jolefsky@ucsd.edu
RI Saltiel, Alan/L-3632-2019
FU UCSD/UCLA NIDDK Diabetes Research Center [P30 DK063491]
FX The authors acknowledge the support of UCSD/UCLA NIDDK Diabetes Research
   Center P30 DK063491.
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NR 41
TC 1442
Z9 1567
U1 21
U2 378
PU AMER SOC CLINICAL INVESTIGATION INC
PI ANN ARBOR
PA 2015 MANCHESTER RD, ANN ARBOR, MI 48104 USA
SN 0021-9738
EI 1558-8238
J9 J CLIN INVEST
JI J. Clin. Invest.
PD JAN 3
PY 2017
VL 127
IS 1
BP 1
EP 4
DI 10.1172/JCI92035
PG 4
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA EI1UK
UT WOS:000392271300001
PM 28045402
OA Bronze, Green Published, Green Submitted
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Aldea, M
   Tomuleasa, C
   Petrushev, B
   Susman, S
   Kacso, GL
   Irimie, A
   Florian, IS
   Soritau, O
AF Aldea, M.
   Tomuleasa, C.
   Petrushev, B.
   Susman, S.
   Kacso, G. L.
   Irimie, A.
   Florian, I. S.
   Soritau, O.
TI Antidiabetic pharmacology: a link between metabolic syndrome and
   neuro-oncology?
SO JOURNAL OF BUON
LA English
DT Review
DE cancer stem cell metabolism; chemotherapy; glioma; metformin
ID OXIDATIVE STRESS; CANCER; METFORMIN; CELL; MECHANISMS; EXPRESSION;
   STRATEGIES; TUMORS; GLUT3; AMPK
AB One of the main topics of the annual meeting of the American Society for Clinical Oncology in 2011 were the results presented on breast cancer chemotherapy and concomitant administration of the oral antidiabetic metformin. The overall agreement was that current evidence is just enough to dramatically change the clinical practice of oncology, and in our case, brain cancer treatment, and that further research is needed to address the relationship between diabetes, metabolism, insulin analogues and neoplasia. Still, it is very interesting to explore the potentially beneficial effects of metformin in glioma chemo/immunotherapy and wait for results in the clinic.
   In the current paper we present the cell and molecular aspects of the metabolic syndrome, metformin administration and cancer chemotherapy, with a special emphasis in neuro-oncology, since brain tumors are usually devastating diseases with an extremely high mortality within two years of diagnosis even when surgical, radiotherapeutic and chemotherapeutic interventions are applied.
C1 [Aldea, M.; Tomuleasa, C.; Petrushev, B.; Soritau, O.] Ion Chiricuta Oncol Inst, Dept Canc Immunol, Cluj Napoca 400015, Romania.
   [Susman, S.] Ion Chiricuta Oncol Inst, Dept Pathol, Cluj Napoca 400015, Romania.
   [Kacso, G. L.] Ion Chiricuta Oncol Inst, Dept Radiat Oncol, Cluj Napoca 400015, Romania.
   [Irimie, A.] Ion Chiricuta Oncol Inst, Dept Surg, Cluj Napoca 400015, Romania.
   [Florian, I. S.] Iuliu Hatieganu Univ Med, Dept Neurosurg, Cluj Napoca, Romania.
C3 Oncology Institute Prof. Dr. Ion Chiricuta; Oncology Institute Prof. Dr.
   Ion Chiricuta; Oncology Institute Prof. Dr. Ion Chiricuta; Oncology
   Institute Prof. Dr. Ion Chiricuta; Iuliu Hatieganu University of
   Medicine & Pharmacy
RP Tomuleasa, C (corresponding author), Ion Chiricuta Oncol Inst, Dept Canc Immunol, Republicii St 34,36, Cluj Napoca 400015, Romania.
EM ciprian.tomuleasa@gmail.com
RI Petrushev, Bobe/AAA-7810-2019; Tomuleasa, Ciprian/F-3030-2017; Irimie,
   Alexandru/C-7046-2012; Aldea, Mihaela/MDT-8065-2025; Florian, Ioan
   Stefan/D-5934-2016
OI Florian, Ioan Stefan/0000-0001-7127-0946; Aldea,
   Mihaela/0000-0001-7685-051X; Tomuleasa, Ciprian/0000-0001-5500-1519
FU Romanian Ministry of Research and Education [1161]
FX All the experiments on glioma cancer stem cell research were carried out
   at the Laboratory of Cell Cultures, Department of Cancer Immunology, Ion
   Chiricuta Oncology Institute in Cluj Napoca, Romania. The financial
   support was possible through a grant of the Romanian Ministry of
   Research and Education, Project of Exploratory Research, Contract ID
   1161.
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U2 9
PU IMPRIMATUR PUBLICATIONS
PI ATHENS
PA 30 DEM POLIORKETES ST, ATHENS, 136 76, GREECE
SN 1107-0625
EI 2241-6293
J9 J BUON
JI J. BUON
PD JUL-SEP
PY 2011
VL 16
IS 3
BP 409
EP 413
PG 5
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA 829FL
UT WOS:000295563900003
PM 22006741
DA 2025-06-11
ER

PT J
AU Pérez-Matute, P
   Zulet, MA
   Martínez, JA
AF Perez-Matute, Patricia
   Angeles Zulet, M.
   Alfredo Martinez, J.
TI Reactive species and diabetes: counteracting oxidative stress to improve
   health
SO CURRENT OPINION IN PHARMACOLOGY
LA English
DT Review
ID NADPH OXIDASE; SUPEROXIDE-PRODUCTION; METABOLIC SYNDROME; FREE-RADICALS;
   INSULIN-RESISTANCE; OXYGEN; DISEASE; OBESITY; REDOX; MITOCHONDRIA
AB Oxidative stress is at the very core of metabolism. Reactive species behave as true second messengers that control important cellular functions. However, under pathological conditions, abnormally large concentrations of these species may lead to permanent changes in signal transduction and gene expression. Attenuation of oxidative stress as a way to improve several diseases such as diabetes has flourished as one of the main challenges of research. The lack of evidence to prove the benefits from antioxidant compounds has led to boost these strategies. Inhibition of reactive oxygen species (ROS) production through the development of inhibitors against NADPH oxidase and mitochondria offers an alternative approach to conventional antioxidant therapies. There is a need to understand oxidative stress process to implement health-disorder approaches.
C1 [Perez-Matute, Patricia; Angeles Zulet, M.; Alfredo Martinez, J.] Univ Navarra, Dept Nutr Food Sci Physiol & Toxicol, Pamplona 31008, Spain.
C3 University of Navarra
RP Pérez-Matute, P (corresponding author), Univ Navarra, Dept Nutr Food Sci Physiol & Toxicol, Pamplona 31008, Spain.
EM cpperez@riojasalud.es; mazulet@unav.es; jalfmtz@unav.es
RI MATUTE, CARMEN/AAB-2907-2019; Martinez Hernandez, J Alfredo/K-8709-2014;
   Zulet, M. Angeles/H-1317-2017
OI Martinez Hernandez, J Alfredo/0000-0001-5218-6941; Perez-Matute,
   Patricia/0000-0003-2232-7971; Zulet, M. Angeles/0000-0002-3926-0892
FU Linea Especial about Nutrition, Obesity, and Health [LE/97]; Health
   Department of the Government of Navarra in Spain [22/2007]
FX Investigations about oxidative stress and human health arc being
   supported by the Linea Especial about Nutrition, Obesity, and Health
   (University of Navarra LE/97) and the Health Department of the
   Government of Navarra in Spain (22/2007).
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NR 64
TC 106
Z9 124
U1 2
U2 21
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1471-4892
EI 1471-4973
J9 CURR OPIN PHARMACOL
JI Curr. Opin. Pharmacol.
PD DEC
PY 2009
VL 9
IS 6
BP 771
EP 779
DI 10.1016/j.coph.2009.08.005
PG 9
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 528KX
UT WOS:000272445300015
PM 19766058
DA 2025-06-11
ER

PT J
AU Chen, WX
   Pang, YL
AF Chen, Weixuan
   Pang, Yanli
TI Metabolic Syndrome and PCOS: Pathogenesis and the Role of Metabolites
SO METABOLITES
LA English
DT Article
DE PCOS; metabolic syndrome; metabolites; gut microbiota; clinical
   application
ID POLYCYSTIC-OVARY-SYNDROME; FARNESOID X RECEPTOR; CHAIN AMINO-ACIDS;
   INSULIN-RESISTANCE; GUT MICROBIOTA; DIAGNOSTIC-CRITERIA; HEPATIC
   STEATOSIS; OXIDATIVE STRESS; ADIPOSE-TISSUE; BILE-ACIDS
AB Polycystic ovary syndrome (PCOS) is one of the most common endocrine diseases among women of reproductive age and is associated with many metabolic manifestations, such as obesity, insulin resistance (IR) and hyperandrogenism. The underlying pathogenesis of these metabolic symptoms has not yet been fully elucidated. With the application of metabolomics techniques, a variety of metabolite changes have been observed in the serum and follicular fluid (FF) of PCOS patients and animal models. Changes in metabolites result from the daily diet and occur during uncommon physiological routines. However, some of these metabolite changes may provide evidence to explain possible mechanisms and new approaches for prevention and therapy. This article reviews the pathogenesis of PCOS metabolic symptoms and the relationship between metabolites and the pathophysiology of PCOS. Furthermore, the potential clinical application of some specific metabolites will be discussed.
C1 [Chen, Weixuan; Pang, Yanli] Peking Univ Third Hosp, Dept Obstet & Gynecol, Ctr Reprod Med, Beijing 100191, Peoples R China.
   [Chen, Weixuan; Pang, Yanli] Peking Univ Third Hosp, Natl Clin Res Ctr Obstet & Gynecol, Beijing 100191, Peoples R China.
   [Chen, Weixuan; Pang, Yanli] Peking Univ, Minist Educ, Key Lab Assisted Reprod, Beijing 100191, Peoples R China.
   [Chen, Weixuan; Pang, Yanli] Beijing Key Lab Reprod Endocrinol & Assisted Repr, Beijing 100191, Peoples R China.
   [Chen, Weixuan; Pang, Yanli] Chinese Acad Med Sci, Res Unit Comprehens Diag, Beijing 100191, Peoples R China.
   [Chen, Weixuan; Pang, Yanli] Chinese Acad Med Sci, Res Unit Treatment Oocyte Maturat Arrest, Beijing 100191, Peoples R China.
C3 Peking University; Peking University; Ministry of Education - China;
   Chinese Academy of Medical Sciences - Peking Union Medical College;
   Chinese Academy of Medical Sciences - Peking Union Medical College
RP Pang, YL (corresponding author), Peking Univ Third Hosp, Dept Obstet & Gynecol, Ctr Reprod Med, Beijing 100191, Peoples R China.; Pang, YL (corresponding author), Peking Univ Third Hosp, Natl Clin Res Ctr Obstet & Gynecol, Beijing 100191, Peoples R China.; Pang, YL (corresponding author), Peking Univ, Minist Educ, Key Lab Assisted Reprod, Beijing 100191, Peoples R China.; Pang, YL (corresponding author), Beijing Key Lab Reprod Endocrinol & Assisted Repr, Beijing 100191, Peoples R China.; Pang, YL (corresponding author), Chinese Acad Med Sci, Res Unit Comprehens Diag, Beijing 100191, Peoples R China.; Pang, YL (corresponding author), Chinese Acad Med Sci, Res Unit Treatment Oocyte Maturat Arrest, Beijing 100191, Peoples R China.
EM weixuanchen@bjmu.edu.cn; yanlipang@bjmu.edu.cn
OI Chen, Weixuan/0000-0003-1660-1700; Pang, Yanli/0000-0003-1967-2416
FU National Key Research and Development Program of China [2018YFC1003200,
   2018YFC1003900]; National Natural Science Foundation of China [82171627,
   82022028]; CAMS Innovation Fund for Medical Sciences [2019-I2M-5-001];
   Key Clinical Projects of Peking University Third Hospital
   [BYSYZD2019020]
FX This research was funded by National Key Research and Development
   Program of China (grant number: 2018YFC1003900); National Key Research
   and Development Program of China (grant number: 2018YFC1003200);
   National Natural Science Foundation of China (grant number: 82022028);
   National Natural Science Foundation of China (grant number: 82171627);
   CAMS Innovation Fund for Medical Sciences(grant number: 2019-I2M-5-001);
   Key Clinical Projects of Peking University Third Hospital (grant number:
   BYSYZD2019020) from Y.L.P.
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NR 170
TC 106
Z9 113
U1 8
U2 50
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2218-1989
J9 METABOLITES
JI Metabolites
PD DEC
PY 2021
VL 11
IS 12
AR 869
DI 10.3390/metabo11120869
PG 18
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA XW8EP
UT WOS:000735845700001
PM 34940628
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Vaidya, D
   Szklo, M
   Cushman, M
   Holvoet, P
   Polak, J
   Bahrami, H
   Jenny, NS
   Ouyang, P
AF Vaidya, D.
   Szklo, M.
   Cushman, M.
   Holvoet, P.
   Polak, J.
   Bahrami, H.
   Jenny, N. S.
   Ouyang, P.
TI Association of endothelial and oxidative stress with metabolic syndrome
   and subclinical atherosclerosis: multi-ethnic study of atherosclerosis
SO EUROPEAN JOURNAL OF CLINICAL NUTRITION
LA English
DT Article
DE metabolic syndrome; biomarkers; coronary artery atherosclerosis; carotid
   arteries
ID ACUTE CORONARY SYNDROMES; INTERCELLULAR-ADHESION MOLECULE-1; CIRCULATING
   OXIDIZED LDL; INSULIN-RESISTANCE; SOLUBLE THROMBOMODULIN;
   CARDIOVASCULAR-DISEASE; HEART-DISEASE; WILLEBRAND,VON FACTOR;
   BODY-COMPOSITION; ARTERY-DISEASE
AB Background/Objectives: A cluster of metabolic abnormalities termed metabolic syndrome (MetS) is associated with vascular endothelial dysfunction and oxidative internal milieu. We examined whether the association of MetS with subclinical atherosclerosis is explained by biomarkers of endothelial damage and oxidative stress. Subjects/Methods: Multi-Ethnic Study of Atherosclerosis (MESA) is a population-based study of 45- to 84-year-old individuals of four US ethnicities without clinical cardiovascular disease. A random sample of 997 MESA participants had data on the following biomarkers: von Willebrand factor, soluble intercellular adhesion molecule-1 (sICAM-1), CD40 ligand (CD40L), soluble thrombomodulin, E-selectin and oxidized LDL (oxLDL). We examined whether the associations of MetS with B-mode ultrasound-defined common and internal carotid intimal-medial thickness (IMT) and coronary artery calcium (CAC) measured using computerized tomography were explained by the biomarkers using multiple regression methods.
   Results: MetS was associated with higher levels of each of the biomarkers (P<0.001, CD40L-suggestive association P=0.004), with greater IMT (P<0.001), and with greater extent of CAC in those in whom CAC was detectable (P=0.01). The association of MetS with measures of subclinical atherosclerosis remained unchanged after adjustment for the biomarkers. After adjusting for MetS, oxLDL was suggestively associated with greater prevalence of detectable CAC (P=0.005) and thicker internal carotid IMT (P=0.002), whereas sICAM-1 was significantly associated with greater prevalence of detectable CAC (P=0.001).
   Conclusions: The association of MetS with subclinical atherosclerosis was independent of its association with biomarkers of endothelial damage and oxidative stress, suggesting that metabolic abnormalities and oxidative endothelial damage may lead to atherosclerotic disease through distinct mechanisms. European Journal of Clinical Nutrition (2011) 65, 818-825; doi: 10.1038/ejcn.2011.47; published online 20 April 2011
C1 [Vaidya, D.; Ouyang, P.] Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21287 USA.
   [Szklo, M.] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA.
   [Cushman, M.; Jenny, N. S.] Univ Vermont, Coll Med, Dept Pathol, Burlington, VT 05405 USA.
   [Holvoet, P.] Katholieke Univ Leuven, Dept Cardiovasc Dis, Louvain, Belgium.
   [Polak, J.] Tufts Univ, Sch Med, Dept Radiol, Boston, MA 02111 USA.
   [Bahrami, H.] Yale Univ, Sch Med, Dept Med, New Haven, CT 06510 USA.
C3 Johns Hopkins University; Johns Hopkins University; Johns Hopkins
   Bloomberg School of Public Health; University of Vermont; KU Leuven;
   Tufts University; Yale University
RP Vaidya, D (corresponding author), Johns Hopkins Univ, Sch Med, Dept Med, 1830 E Monument St,8028A, Baltimore, MD 21287 USA.
EM dvaidya1@jhmi.edu
RI HOLVOET, PAUL/T-8434-2017; Vaidya, Dhananjay/AAL-5684-2020; Cushman,
   Mary/K-1157-2019
OI Holvoet, Paul/0000-0001-9201-0772; Vaidya,
   Dhananjay/0000-0002-7164-1601; Szklo, Moyses/0000-0001-9433-6266;
   Cushman, Mary/0000-0002-7871-6143
FU National Heart, Lung and Blood Institute [N01-HC-95159, N01-HC-95169];
   National Center for Research Resources [UL1 RR 025005]; Belgian Federal
   Government [P06/30]; Bijzonder Onderzoeksfonds of the Katholieke
   Universiteit Leuven [OT/06/56]
FX This research was supported by contracts N01-HC-95159 through
   N01-HC-95169 from the National Heart, Lung and Blood Institute. We thank
   the other investigators, the staff and the participants of the MESA
   study for their valuable contributions. A full list of participating
   MESA investigators and institutions can be found at
   http://www.mesa-nhlbi.org. In addition, DV was supported by UL1 RR
   025005 from the National Center for Research Resources, and funding for
   PH was provided by the Interuniversitaire Attractiepolen Programma of
   the Belgian Federal Government (P06/30) and the Bijzonder
   Onderzoeksfonds of the Katholieke Universiteit Leuven (OT/06/56).
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NR 30
TC 36
Z9 37
U1 0
U2 9
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0954-3007
J9 EUR J CLIN NUTR
JI Eur. J. Clin. Nutr.
PD JUL
PY 2011
VL 65
IS 7
BP 818
EP 825
DI 10.1038/ejcn.2011.47
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 788OT
UT WOS:000292455000006
PM 21505504
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Gatselis, NK
   Ntaios, G
   Makaritsis, K
   Dalekos, GN
AF Gatselis, Nikolaos K.
   Ntaios, George
   Makaritsis, Konstantinos
   Dalekos, George N.
TI Adiponectin: a key playmaker adipocytokine in non-alcoholic fatty liver
   disease
SO CLINICAL AND EXPERIMENTAL MEDICINE
LA English
DT Review
DE Non-alcoholic fatty liver disease; Steatosis; Adiponectin;
   Adipocytokines
ID MOLECULAR-WEIGHT ADIPONECTIN; INSULIN-RESISTANCE; SERUM ADIPONECTIN;
   HEPATIC STEATOSIS; PLASMA ADIPONECTIN; TNF-ALPHA;
   HEPATOCELLULAR-CARCINOMA; INDEPENDENT PREDICTOR; METABOLIC SYNDROME;
   OXIDATIVE STRESS
AB Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic syndrome and can progress to cirrhosis, liver failure, and hepatocellular carcinoma. In the last two decades, the prevalence of NAFLD has been growing in most developed countries, mainly as a consequence of its close association with obesity and diabetes mellitus. The exact pathogenesis of NAFLD and especially the mechanisms leading to disease progression have not been completely understood. Adipocytes produce and secrete several bioactive substances known as adipocytokines which are implicated in the pathogenesis of the disease. Among them, adiponectin is an insulin-sensitizing adipocytokine possessing multiple beneficial effects on obesity-related medical complication. This review focuses on the role of adiponectin in NAFLD pathogenesis and its potential use as a diagnostic tool but also as therapeutic target for NAFLD management.
C1 [Gatselis, Nikolaos K.; Ntaios, George; Makaritsis, Konstantinos; Dalekos, George N.] Thessaly Univ Med Sch, Dept Med, Larisa 41110, Thessaly, Greece.
   [Gatselis, Nikolaos K.; Ntaios, George; Makaritsis, Konstantinos; Dalekos, George N.] Thessaly Univ Med Sch, Res Lab Internal Med, Larisa 41110, Thessaly, Greece.
C3 University of Thessaly; University of Thessaly
RP Dalekos, GN (corresponding author), Thessaly Univ Med Sch, Dept Med, Larisa 41110, Thessaly, Greece.
EM dalekos@med.uth.gr
RI Ntaios, George/AAG-1908-2019
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NR 122
TC 49
Z9 53
U1 1
U2 16
PU SPRINGER-VERLAG ITALIA SRL
PI MILAN
PA VIA DECEMBRIO, 28, MILAN, 20137, ITALY
SN 1591-8890
EI 1591-9528
J9 CLIN EXP MED
JI Clin. Exper. Med.
PD MAY
PY 2014
VL 14
IS 2
BP 121
EP 131
DI 10.1007/s10238-012-0227-0
PG 11
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA AG1CP
UT WOS:000335152900002
PM 23292294
DA 2025-06-11
ER

PT J
AU Belcastro, V
   D'Egidio, C
   Striano, P
   Verrotti, A
AF Belcastro, Vincenzo
   D'Egidio, Claudia
   Striano, Pasquale
   Verrotti, Alberto
TI Metabolic and endocrine effects of valproic acid chronic treatment
SO EPILEPSY RESEARCH
LA English
DT Review
DE Valproic acid; Epileptic syndromes; Metabolic syndrome; Atherosclerosis
ID INTIMA-MEDIA THICKNESS; VASCULAR RISK-FACTORS; FATTY LIVER-DISEASE;
   ANTIEPILEPTIC DRUGS; WEIGHT-GAIN; EPILEPTIC PATIENTS; SODIUM VALPROATE;
   SERUM-INSULIN; HOMOCYSTEINE METABOLISM; CARDIOVASCULAR RISK
AB Treatment of epileptic patients with valproic acid (VPA) may be associated with substantial weight changes that may increase morbidity and impair adherence to the treatment regimen. VPA-induced weight gain seems to be associated with many metabolic disturbances; the most frequent are hyperinsulinemia and insulin resistance, hyperleptinemia and leptin resistance. Patients who gain weight during VPA therapy can develop dyslipidemia and metabolic syndrome that are associated with long-term vascular complications such as hypertension and atherosclerosis. Moreover, an elevation in the levels of uric acid and homocysteine, together with oxidative stress, may contribute to atherosclerotic risk in patients under long-term therapy with VPA.
   The aim of this review is to discuss the metabolic and endocrine effects of VPA chronic treatment in patients with epilepsy. (C) 2013 Elsevier B.V. All rights reserved.
C1 [Belcastro, Vincenzo] St Anna Hosp, Neurol Unit, Dept Neurosci, Como, Italy.
   [D'Egidio, Claudia] Univ G dAnnunzio, Dept Pediat, Chieti, Italy.
   [Striano, Pasquale] Univ Genoa, G Gaslini Inst, Pediat Neurol & Muscular Dis Unit, Dept Neurosci Rehabil Ophtalmol Genet Maternal &, Genoa, Italy.
   [Verrotti, Alberto] Univ Perugia, Dept Pediat, I-06100 Perugia, Italy.
C3 University of Ferrara; Arcispedale Sant'Anna; G d'Annunzio University of
   Chieti-Pescara; University of Genoa; IRCCS Istituto Giannina Gaslini;
   University of Perugia
RP Belcastro, V (corresponding author), St Anna Hosp, Neurol Unit, Dept Neurosci, Como, Italy.
EM vincenzobelcastro@libero.it
RI Spalice, Alberto/AFI-5798-2022; Belcastro, Vincenzo/IAM-0167-2023;
   Striano, Pasquale/F-9117-2014
OI Belcastro, Vincenzo/0000-0002-3416-2900; , Alberto/0000-0002-3670-6115
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NR 102
TC 108
Z9 113
U1 0
U2 19
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0920-1211
EI 1872-6844
J9 EPILEPSY RES
JI Epilepsy Res.
PD NOV
PY 2013
VL 107
IS 1-2
BP 1
EP 8
DI 10.1016/j.eplepsyres.2013.08.016
PG 8
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 273HB
UT WOS:000328524800001
PM 24076030
DA 2025-06-11
ER

PT J
AU Schilder, RJ
   Marden, JH
AF Schilder, Rudolf J.
   Marden, James H.
TI Metabolic syndrome and obesity in an insect
SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF
   AMERICA
LA English
DT Article
DE chronic inflammation; insect disease model obesity lipid metabolism;
   parasite effects
ID INSULIN-RESISTANCE; SKELETAL-MUSCLE; ADIPOSE-TISSUE; IMMUNE-SYSTEM;
   POWER OUTPUT; P38 MAPK; INFLAMMATION; EXPRESSION; GUT; FAT
AB Dragonflies infected with noninvasive gregarine gut parasites (Microsporidia, Apicomplexa) have reduced flight-muscle performance, an inability to metabolize lipid in their muscles, twofold-elevated hemolymph carbohydrate concentrations, and they accumulate fat in their thorax in a manner analogous to mammalian obesity. Gregarine infection is associated with inappropriate responses of hemolymph carbohydrate concentration to insulin and with chronic activation in the flight muscles of p38 MAP kinase, a signaling molecule involved in immune and stress responses. Short-term exposure to gregarine excretory/secretory products caused elevated blood carbohydrate and p38 MAPK activation in healthy individuals. These characteristics comprise a set of symptoms and processes that are known in mammals as metabolic syndrome but which have not previously been described in other animal taxa. In addition to expanding the known taxonomic breadth of metabolic disease, these results indicate that insects may be useful experimental models for studying its underlying biology and mechanisms.
C1 Penn State Univ, Dept Biol, Mueller Lab 208, University Pk, PA 16802 USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE);
   Pennsylvania State University; Pennsylvania State University -
   University Park; Penn State Behrend
RP Schilder, RJ (corresponding author), Penn State Univ, Dept Biol, Mueller Lab 208, University Pk, PA 16802 USA.
EM rschilder2@uninotes.unl.edu
RI /M-7215-2019
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NR 46
TC 57
Z9 68
U1 0
U2 25
PU NATL ACAD SCIENCES
PI WASHINGTON
PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA
SN 0027-8424
J9 P NATL ACAD SCI USA
JI Proc. Natl. Acad. Sci. U. S. A.
PD DEC 5
PY 2006
VL 103
IS 49
BP 18805
EP 18809
DI 10.1073/pnas.0603156103
PG 5
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 114TZ
UT WOS:000242689800075
PM 17132732
OA Green Published
DA 2025-06-11
ER

PT J
AU Ferreira, MD
   Scalzo, MD
   Rodriguez, S
   D'Alessandro, ME
AF Ferreira, Maria del Rosario
   Scalzo, Maria de los Milagros
   Rodriguez, Silvia
   D'Alessandro, Maria Eugenia
TI Changes in cerebral cortex redox status and cognitive performance in
   short-and long-term high-sucrose diet fed rats
SO PHYSIOLOGY & BEHAVIOR
LA English
DT Article
DE Cerebral cortex; Oxidative stress; Cognition; High-sucrose diet;
   Metabolic syndrome; Rats
ID ADIPOSE-TISSUE DYSFUNCTION; INSULIN-RESISTANT RATS; METABOLIC SYNDROME;
   OXIDATIVE STRESS; RICH DIET; INFLAMMATORY CYTOKINES; SKELETAL-MUSCLE;
   BRAIN; GLUTATHIONE; PATHOPHYSIOLOGY
AB Rising evidence suggests that Metabolic Syndrome (MetS) would be correlated with the development of neurodegenerative diseases. Although this has emerged as a relevant area of research, it has not been fully explored. It is not clear if a greater impairment of the metabolic peripheral environment is accompanied by a greater impairment of the central nervous system. We have previously shown that feeding rats with a highsucrose diet (HSD) represents an animal model that resembles the human MetS phenotype. The aim of the present work was to assess in rats fed a HSD for a short (3 weeks-wk) or a long (15 weeks-wk) term, whether the worsening of the peripheral metabolic and hormonal profile that occur as the time of HSD consumption increases, is also accompanied by a worsening of oxidative stress in the cerebral cortex and/or cognitive behavior. Male Wistar rats received a HSD or a control diet during 3 wk or 15 wk. We found an increase in reactive oxygen species (ROS), thiobarbituric acid reactive substances (TBARS), advanced glycation end products (AGEs) and glutathione peroxidase (GPx) and glutathione reductase (GR) enzyme activities in the cerebral cortex of 3 wk HSD-fed rats. All of these parameters, except for the GPx, were also increased in the 15 wk HSD-fed group and values were similar to those observed at 3 wk. Glutathione reduced form (GSH), catalase (CAT) activity and brain-to-body weight ratio were reduced in 15 wk HSD-fed animals. Glutathione S- transferase (GST) was similar in all dietary groups. A poor performance in novel object recognition test and T-maze memory tasks was observed in 3 wk and 15 wk HSD-fed rats in a similar magnitude. Our results add new evidence related to the association between an adverse peripheral metabolic environment and brain/cognitive dysfunction.
C1 [Ferreira, Maria del Rosario; Scalzo, Maria de los Milagros; D'Alessandro, Maria Eugenia] Univ Nacl Litoral, Fac Bioquim & Ciencias Biol, Lab Estudio Enfermedades Metab Relacionadas Nutr, Ciudad Univ, Santa Fe, Argentina.
   [Ferreira, Maria del Rosario; Rodriguez, Silvia; D'Alessandro, Maria Eugenia] Consejo Nacl Invest Cient & Tecn CONICET, Buenos Aires, Argentina.
C3 National University of the Littoral; Consejo Nacional de Investigaciones
   Cientificas y Tecnicas (CONICET)
RP Ferreira, MD (corresponding author), Univ Nacl Litoral, Fac Bioquim & Ciencias Biol, cc242,Ciudad Univ, RA-3000 Santa Fe, Argentina.
EM mrferreira@fbcb.unl.edu.ar
OI D' Alessandro, Maria Eugenia/0000-0001-6008-5614; Ferreira, Maria del
   Rosario/0000-0003-0760-9495
FU Agencia Nacional de Promocion de la Investigacion, el Desarrollo
   Tecnologico y la Innovacion- FONCyT, Argentina [PICT-2021-I-INVI-00200];
   Universidad Nacional del Litoral, Argentina [50620190100008LI]
FX This work was supported by Agencia Nacional de Promocion de la
   Investigacion, el Desarrollo Tecnologico y la Innovacion- FONCyT,
   Argentina [grant PICT-2021-I-INVI-00200] and Universidad Nacional del
   Litoral, Argentina [grant CAI + D #50620190100008LI] .
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NR 74
TC 1
Z9 1
U1 1
U2 1
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0031-9384
EI 1873-507X
J9 PHYSIOL BEHAV
JI Physiol. Behav.
PD MAR 1
PY 2025
VL 290
AR 114776
DI 10.1016/j.physbeh.2024.114776
EA DEC 2024
PG 11
WC Psychology, Biological; Behavioral Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Behavioral Sciences
GA P0T1P
UT WOS:001375133700001
PM 39638221
DA 2025-06-11
ER

PT J
AU Andrade, JL
   Hong, YR
   Lee, AM
   Miller, DR
   Williams, C
   Thompson, LA
   Bright, MA
   Cardel, MI
AF Andrade, Joanne L.
   Hong, Young-Rock
   Lee, Alexandra M.
   Miller, Darci R.
   Williams, Charlette
   Thompson, Lindsay A.
   Bright, Melissa A.
   Cardel, Michelle, I
TI Adverse Childhood Experiences Are Associated with Cardiometabolic Risk
   among Hispanic American Adolescents
SO JOURNAL OF PEDIATRICS
LA English
DT Article
ID BLOOD-PRESSURE; ARTERIAL STIFFNESS; VIOLENCE EXPOSURE; HEART-DISEASE;
   SOCIAL-STATUS; OBESITY; STRESS; TRAUMA; HEALTH; ABUSE
AB Objective To assess the relationship between adverse childhood experiences (ACEs) and cardiometabolic risk among Hispanic adolescents.
   Study design This cross-sectional study was conducted at an academic research center in Gainesville, Florida. Participants were locally recruited, and data were collected from June 2016 to July 2018. Participants (n = 133, 60.2% female) were healthy adolescents aged 15-21 years who self-identified as Hispanic, were born in the US, and had a body mass index (BMI) between >= 18.5 and 40 pound kg/m(2). Primary outcomeswere BMI, body fat percentage, waist circumference, and resting blood pressure. Associations between ACEs and cardiometabolic measures were assessed by multivariable logistic regression models, which controlled for sex, age, parental education, and food insecurity. Results were sex-stratified to assess potential variations.
   Results Reporting (3)4 ACEs (28.6%) was significantly associated with a greater BMI (P =.004), body fat percentage (P = .02), and diastolic blood pressure (P =.05) compared with reporting <4 ACEs. Female participants reporting >= 4 ACEs were significantly more likely to have a greater BMI (P = .04) and body fat percentage (P = .03) whereas male participants reporting >= 4 ACEs were significantly more likely to have a greater BMI (P =.04), systolic blood pressure (P = .03), and diastolic blood pressure (P = .03).
   Conclusions Hispanic adolescent participants who experienced >= 4 ACEs were more likely to have elevated risk markers of obesity and cardiometabolic disease. Further research is needed to elucidate the physiological mechanisms driving these relationships.
C1 [Andrade, Joanne L.; Lee, Alexandra M.; Miller, Darci R.; Williams, Charlette; Thompson, Lindsay A.; Cardel, Michelle, I] Univ Florida, Dept Hlth Outcomes & Biomed Informat, Gainesville, FL USA.
   [Hong, Young-Rock] Univ Florida, Coll Publ Hlth & Hlth Profess, Dept Hlth Serv Res Management & Policy, Gainesville, FL USA.
   [Thompson, Lindsay A.; Cardel, Michelle, I] Univ Florida, Dept Pediat, Gainesville, FL USA.
   [Bright, Melissa A.] Univ Florida, Coll Med, Dept Obstet & Gynecol, Gainesville, FL 32610 USA.
   [Cardel, Michelle, I] Univ Florida, Ctr Integrat Cardiovasc & Metab Dis, Gainesville, FL USA.
   [Cardel, Michelle, I] WW Int Inc, New York, NY USA.
C3 State University System of Florida; University of Florida; State
   University System of Florida; University of Florida; State University
   System of Florida; University of Florida; State University System of
   Florida; University of Florida; State University System of Florida;
   University of Florida
RP Cardel, MI (corresponding author), 2004 Mowry Rd,Suite 2247, Gainesville, FL 32610 USA.
EM mcardel@ufl.edu
RI Lee, Alexandra/HTN-7539-2023; Hong, Young-Rock/AAK-8856-2020
OI Hong, Young-Rock/0000-0002-0366-5687; Williams,
   Charlette/0000-0002-8055-1210
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   World Health Organization Mental Health Gap Action Programme World Health Organization Mental Health Gap Action Programme, 2015, UPD MENT HLTH GAP AC
NR 52
TC 10
Z9 10
U1 0
U2 4
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0022-3476
EI 1097-6833
J9 J PEDIATR-US
JI J. Pediatr.
PD OCT
PY 2021
VL 237
BP 267
EP +
DI 10.1016/j.jpeds.2021.06.024
EA SEP 2021
PG 10
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Pediatrics
GA UV9QX
UT WOS:000699805300047
PM 34147498
DA 2025-06-11
ER

PT J
AU Babish, JG
   Dahlberg, CJ
   Ou, JJ
   Keller, WJ
   Gao, W
   Kaadige, MR
   Brabazon, H
   Lamb, J
   Soudah, HC
   Kou, XL
   Zhang, Z
   Pacioretty, LM
   Tripp, ML
AF Babish, John G.
   Dahlberg, Clinton J.
   Ou, Joseph J.
   Keller, William J.
   Gao, Wei
   Kaadige, Mohan R.
   Brabazon, Holly
   Lamb, Joseph
   Soudah, Hani C.
   Kou, Xiaolan
   Zhang, Zhe
   Pacioretty, Linda M.
   Tripp, Matthew L.
TI Synergistic in vitro antioxidant activity and observational clinical
   trial of F105, a phytochemical formulation including Citrus
   bergamia, in subjects with moderate cardiometabolic risk factors
SO CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
LA English
DT Article
DE cardiometabolic disease; bergamot; antioxidant; myeloperoxidase;
   oxidized LDL; dyslipidemia; HbA1c
ID LOW-DENSITY-LIPOPROTEIN; LIPID HYDROPEROXIDE; CHOLESTEROL RATIO;
   OXIDATIVE STRESS; POITEAU JUICE; OXIDIZED LDL; PAI-1; INFLAMMATION;
   ACTIVATION; EXPRESSION
AB We examined the clinical safety and efficacy of F105 in 11 subjects with moderate dyslipidemia. F105 is a combination of bergamot fruit extract (Citrus bergamia, BFE) and 9 phytoextracts selected for their ability to improve the antioxidant and anti-inflammatory activity of BFE. In vitro F105 exhibited a synergistic inhibition of oxygen radical absorbing capacity, peroxynitrite formation, and myeloperoxidase activity. Following 12 weeks of F105 daily, no treatment-related adverse events or changes in body mass were seen. Statistically significant changes were noted in total cholesterol (-7.3%), LDL-cholesterol (-10%), non-HDL cholesterol (-7.1%), cholesterol/HDL (-26%), and apolipoprotein B (-2.8%). A post hoc analysis of 8 subjects with HbA1c > 5.4 and HOMA-IR score > 2 or elevated triglycerides revealed additional statistically significant changes in addition to those previously observed in all subjects including triglycerides (-27%), oxLDL (-19%), LDL/HDL (-25%), triglycerides/HDL (-27%), oxLDL/HDL (-25%), and PAI-1 (-37%). A follow-up case report of a 70-year-old female patient, nonresponsive to statin therapy and placed on F105 daily, demonstrated improved cardiometabolic variables over 12 weeks similar to the subgroup. In summary, F105 was clinically well-tolerated and effective for ameliorating dyslipidemia in subjects with moderate cardiometabolic risk factors, particularly in the individuals with HbA1c > 5.4%.
C1 [Babish, John G.; Pacioretty, Linda M.] Bionexus Ltd, 53 Brown Rd,Suite B, Ithaca, NY 14850 USA.
   [Dahlberg, Clinton J.; Ou, Joseph J.; Keller, William J.; Gao, Wei; Kaadige, Mohan R.; Brabazon, Holly; Lamb, Joseph; Tripp, Matthew L.] Nat Sunshine Prod, Hughes Ctr Res & Innovat, 2500 Execut Pkwy, Lehi, UT 84043 USA.
   [Soudah, Hani C.] Tenet Healthcare Syst, Stella Maris Obes Med, 2315 Dougherty Ferry Rd,Suite 109, St Louis, MO 63122 USA.
   [Soudah, Hani C.] Washington Univ, Sch Med, 660 S Euclid Ave, St Louis, MO 63110 USA.
   [Kou, Xiaolan; Zhang, Zhe] Nat Sunshine Prod, 1655 North Main St, Spanish Fork, UT 84660 USA.
C3 Washington University (WUSTL)
RP Babish, JG (corresponding author), Bionexus Ltd, 53 Brown Rd,Suite B, Ithaca, NY 14850 USA.
EM jgb7@cornell.edu
OI Gao, Wei/0000-0003-0843-1449; Brabazon, Holly/0000-0001-8153-9363
FU Nature's Sunshine Products Inc., (NSP), Lehi, Utah
FX Financial support for this study was provided by Nature's Sunshine
   Products Inc., (NSP), Lehi, Utah. Joseph Lamb, Linda M. Pacioretty, and
   John G. Babish serve as consultants to NSP. Hani C. Soudah serves on the
   medical and scientific advisory board to NSP. All other authors are
   employees of NSP. The in vitro studies were conducted at Hughes Center
   For Research and Innovation Laboratories and Research Clinic, NSP. The
   clinical study was conducted at the High Desert Heart Institute,
   Victorville, California; we thank Siva Arunasalam and Dan Austin for
   conducting the clinical study. Recognition is given to members of the
   NSP Medical and Science Advisory Board, Ingrum Bankston Jr., Sang Geon
   Kim, and Luis N. Pacheco, for their critical review of this manuscript.
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NR 53
TC 15
Z9 15
U1 0
U2 9
PU CANADIAN SCIENCE PUBLISHING
PI OTTAWA
PA 65 AURIGA DR, SUITE 203, OTTAWA, ON K2E 7W6, CANADA
SN 0008-4212
EI 1205-7541
J9 CAN J PHYSIOL PHARM
JI Can. J. Physiol. Pharmacol.
PD DEC
PY 2016
VL 94
IS 12
BP 1257
EP 1266
DI 10.1139/cjpp-2016-0062
PG 10
WC Pharmacology & Pharmacy; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Physiology
GA EC4JS
UT WOS:000388095500003
PM 27463949
OA hybrid
DA 2025-06-11
ER

PT J
AU Brea, A
   Puzo, J
AF Brea, Angel
   Puzo, Jose
TI Non-alcoholic fatty liver disease and cardiovascular risk
SO INTERNATIONAL JOURNAL OF CARDIOLOGY
LA English
DT Review
DE Fatty liver; Cardiovascular disease; Alcohol; Non-alcoholic fatty liver
   disease
ID GAMMA-GLUTAMYL-TRANSFERASE; CORONARY-HEART-DISEASE; TRIGLYCERIDE
   TRANSFER PROTEIN; ENDOPLASMIC-RETICULUM STRESS; RANDOMIZED
   CONTROLLED-TRIAL; TERM-FOLLOW-UP; HEPATIC STEATOSIS; METABOLIC SYNDROME;
   INSULIN-RESISTANCE; WEIGHT-LOSS
AB The term "Non-alcoholic fatty liver disease" (NAFLD) covers a series of liver lesions similar to those induced by alcohol, but not caused by alcohol use. The importance of NAFLD lies in the high prevalence in Western societies and, from the point of view of the liver, in its progression from steatosis to cirrhosis and liver cancer. More recently, NAFLD has been found to be associated with lipid metabolism disorders, the deposition of fat outside of the adipocytes, insulin resistance and Metabolic Syndrome. Also attributed to NAFLD is a heightened systemic pro-inflammatory state, which accelerates arteriosclerosis, thereby increasing cardiovascular risk and associated cardiovascular events. Here we provide an update to the etiopathogenesis of NAFLD, its influence on cardiovascular disease, and the treatment options. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
C1 [Brea, Angel] Hosp San Pedro, Unidad Lipidos, Serv Med Interna, Logrono, Spain.
   [Puzo, Jose] Hosp San Jorge, Unidad Lipidos, Bioquim Clin, Huesca, Spain.
C3 Hospital Universidad San Jorge
RP Puzo, J (corresponding author), Hosp Gen San Jorge, Unidad Lipidos, Bioquim Clin, P Martinez Velasco 36, Huesca 22004, Spain.
EM jpuzo@unizar.es
RI Puzo Foncillas, Jose/AAE-5827-2021
OI Puzo Foncillas, Jose/0000-0002-1309-4363
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NR 157
TC 77
Z9 85
U1 1
U2 28
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0167-5273
EI 1874-1754
J9 INT J CARDIOL
JI Int. J. Cardiol.
PD AUG 20
PY 2013
VL 167
IS 4
BP 1109
EP 1117
DI 10.1016/j.ijcard.2012.09.085
PG 9
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 206ZV
UT WOS:000323566800017
PM 23141876
DA 2025-06-11
ER

PT J
AU Babtan, AM
   Ilea, A
   Bosca, BA
   Crisan, M
   Petrescu, NB
   Collino, M
   Sainz, RM
   Gerlach, JQ
   Câmpian, RS
AF Babtan, Anida M.
   Ilea, Aranka
   Bosca, Bianca A.
   Crisan, Maria
   Petrescu, Nausica B.
   Collino, Massimo
   Sainz, Rosa M.
   Gerlach, Jared Q.
   Campian, Radu S.
TI Advanced glycation end products as biomarkers in systemic diseases:
   premises and perspectives of salivary advanced glycation end products
SO BIOMARKERS IN MEDICINE
LA English
DT Review
DE advanced glycation end products; AGEs; AGEs diagnosis and
   downregulation; biomarkers; biosensor; chronic low-level inflammation;
   diet-related disease; metabolic syndrome; metainflammation; saliva
ID MAILLARD REACTION; RISK-FACTOR; PROTEIN GLYCATION; OXIDATIVE STRESS;
   PERIODONTITIS PATIENTS; INCREASED ACCUMULATION; CARBOXYMETHYL-LYSINE;
   DIETARY GLYCOTOXINS; CALORIC RESTRICTION; LIPID-PEROXIDATION
AB Advanced glycation end products (AGEs) are glycated proteins associated with high dry temperature food processing, coloring and flavor modification of food products. Previous studies on diet-related disease support the role of the glycation products as biomarkers in local and general proinflammatory response. Exogenous and endogenous AGEs are involved in chronic low-level inflammation, which underlies the onset of metabolic syndrome influenced by food intake, there by demonstrating their implication in diet-related pathologies. Although studies have revealed a strong association between the accumulation of AGEs and the occurrence/ worsening of metabolic diseases, their routine use for the diagnosis or monitoring of local and general disease has not yet been reported.
   [GRAPHICS]
   .
C1 [Babtan, Anida M.; Ilea, Aranka; Petrescu, Nausica B.; Campian, Radu S.] Iuliu Hatieganu Univ Med & Pharm, Fac Dent, Oral Hlth & Dent Off Management, Dept Oral Rehabil, Victor Babes St, Cluj Napoca 400012, Romania.
   [Bosca, Bianca A.; Crisan, Maria] Iuliu Hatieganu Univ Med & Pharm, Dept Histol, Louis Pasteur St 4, Cluj Napoca 400349, Romania.
   [Collino, Massimo] Univ Turin, Dept Drug Sci & Technol, Corso Raffaello 33, I-10125 Turin, Italy.
   [Sainz, Rosa M.] Univ Oviedo, Dept Morphol & Cell Biol, Campus Cristo C Julian Claveria 6, E-33006 Oviedo, Spain.
   [Gerlach, Jared Q.] Natl Univ Ireland Galway, Natl Ctr Biomed Engn Sci, Glycosci Grp, Galway H91 CF50, Ireland.
C3 Iuliu Hatieganu University of Medicine & Pharmacy; Iuliu Hatieganu
   University of Medicine & Pharmacy; University of Turin; University of
   Oviedo
RP Bosca, BA (corresponding author), Iuliu Hatieganu Univ Med & Pharm, Dept Histol, Louis Pasteur St 4, Cluj Napoca 400349, Romania.
EM biancabosca@yahoo.com
RI Boșca, Bianca/AAS-7779-2021; crisan, maria/AAA-8119-2021; Ilea,
   Aranka/N-6040-2014; Collino, Massimo/AAK-8532-2020; Babtan,
   Anida-Maria/AAO-2548-2020; Petrescu, Nausica/ABA-2480-2022; Sainz, Rosa
   M./N-5885-2014; Gerlach, Jared/K-2698-2013
OI Sainz, Rosa M./0000-0003-3048-5582; Gerlach, Jared/0000-0001-7343-7201;
   Bosca, Adina Bianca/0000-0002-3835-2090
FU 'Iuliu Hatieganu' University of Medicine and Pharmacy Cluj-Napoca,
   Romania [3999/01.10.2016]; COFUND-ERA-HDHL ERANET Project, European and
   International Cooperation - Subprogram 3.2 -Horizon 2020, PNCDI III
   Program - Biomarkers for Nutrition and Health - 'Innovative
   technological approaches for validation of salivary AGEs as novel
   biomarkers in eva [25/1.09.2017]
FX This study was supported by 'Iuliu Hatieganu' University of Medicine and
   Pharmacy Cluj-Napoca, Romania PhD grant no. 3999/01.10.2016, and
   partially by the COFUND-ERA-HDHL ERANET Project, European and
   International Cooperation - Subprogram 3.2 -Horizon 2020, PNCDI III
   Program - Biomarkers for Nutrition and Health - 'Innovative
   technological approaches for validation of salivary AGEs as novel
   biomarkers in evaluation of risk factors in diet-related diseases',
   grant no. 25/1.09.2017. The authors have no other relevant affiliations
   or financial involvement with any organization or entity with a
   financial interest in or financial conflict with the subject matter or
   materials discussed in the manuscript apart from those disclosed.
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NR 135
TC 19
Z9 20
U1 3
U2 40
PU FUTURE MEDICINE LTD
PI LONDON
PA UNITEC HOUSE, 3RD FLOOR, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON, N3
   1QB, ENGLAND
SN 1752-0363
EI 1752-0371
J9 BIOMARK MED
JI Biomark. Med.
PD APR
PY 2019
VL 13
IS 6
BP 479
EP 495
DI 10.2217/bmm-2018-0448
PG 17
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA IM0TZ
UT WOS:000477703700007
PM 30968701
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Baskar, S
   Jhaveri, S
   Alkhouri, N
AF Baskar, Shankar
   Jhaveri, Simone
   Alkhouri, Naim
TI Cardiovascular risk in pediatric nonalcoholic fatty liver disease:
   recent advances
SO CLINICAL LIPIDOLOGY
LA English
DT Review
DE cardiovascular diseases; dyslipidemias; fatty liver; genetic;
   inflammation; insulin resistance; metabolic syndrome; nonalcoholic fatty
   liver disease; oxidative stress; pediatric obesity; polymorphism
ID INTIMA-MEDIA THICKNESS; CORONARY-HEART-DISEASE; 3RD NATIONAL-HEALTH;
   OBESE CHILDREN; INSULIN-RESISTANCE; METABOLIC SYNDROME; ARTERIAL
   STIFFNESS; CAROTID-ARTERY; UNITED-STATES; ADOLESCENTS
AB Nonalcoholic fatty liver disease (NAFLD) is the most common form of pediatric chronic liver disease in developed countries. NAFLD has risen to epidemic proportions paralleling that of childhood obesity. It is becoming increasingly evident that NAFLD is strongly linked with cardiovascular disease (CVD), which is the leading cause of mortality in the adult NAFLD population. It is very important for physicians caring for children being cognizant of the potential role of childhood NAFLD as an independent risk factor for CVD. Childhood is a time period where subclinical CVD can be detected, giving us the potential ability to halt or reverse the disease process. In this review, we discuss recent evidence linking childhood NAFLD to CVD and potential pathogenic links.
C1 [Baskar, Shankar; Jhaveri, Simone] Childrens Hosp, Cleveland Clin, Dept Pediat, Cleveland, OH 44195 USA.
   [Alkhouri, Naim] Childrens Hosp, Cleveland Clin, Dept Pediat Gastroenterol, Cleveland, OH 44195 USA.
   [Alkhouri, Naim] Cleveland Clin, Digest Dis Inst, Cleveland, OH 44106 USA.
C3 Cleveland Clinic Foundation; Cleveland Clinic Foundation; Cleveland
   Clinic Foundation
RP Alkhouri, N (corresponding author), Childrens Hosp, Cleveland Clin, Dept Pediat Gastroenterol, 9500 Euclid Ave,A111, Cleveland, OH 44195 USA.
EM alkhoun@ccf.org
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NR 75
TC 2
Z9 2
U1 0
U2 3
PU FUTURE MEDICINE LTD
PI LONDON
PA UNITEC HOUSE, 3RD FLOOR, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON, N3
   1QB, ENGLAND
SN 1758-4299
EI 1758-4302
J9 CLIN LIPIDOL
JI Clin. Lipidol.
PY 2015
VL 10
IS 4
BP 351
EP 362
DI 10.2217/clp.15.26
PG 12
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA CP7WF
UT WOS:000360099100008
DA 2025-06-11
ER

PT J
AU Katsarou, A
   Triposkiadis, F
   Skoularigis, J
   Papageorgiou, C
   Panagiotakos, DB
AF Katsarou, A.
   Triposkiadis, F.
   Skoularigis, J.
   Papageorgiou, C.
   Panagiotakos, D. B.
TI Evaluating the role of Mediterranean diet and eating behaviors on the
   likelihood of having a non-fatal acute coronary syndrome, under the
   context of stress perception: a case-control study
SO EUROPEAN JOURNAL OF CLINICAL NUTRITION
LA English
DT Article
ID CARDIOVASCULAR-DISEASE RISK; PERCEIVED STRESS; METABOLIC SYNDROME;
   PHYSICAL-ACTIVITY; GLOBAL MEASURE; HEART-DISEASE; PREVENTION;
   DEPRESSION; HEALTH; METAANALYSIS
AB BACKGROUND/OBJECTIVES: Mediterranean diet and perceived stress have long been associated with the likelihood of having an acute coronary syndrome (ACS). The aim of this study was to evaluate whether the Mediterranean diet and other eating behaviors mediate and/or moderate the unfavorable impact of perceived stress on the likelihood of having a non-fatal ACS.
   SUBJECTS/METHODS: This is a case control study with individuals matched by age and sex. A total of 250 consecutive patients (60 +/- 11 years, 78% men) with a first ACS and 250 population-based, control subjects (60 +/- 8.6 years, 77.6% men) were enrolled. Perceived stress levels were evaluated with the Perceived Stress Scale (PSS-14; range 0-14), and adherence to the Mediterranean diet was assessed by the MedDietScore (range 0-55). Stress eating, eating heavy meals and eating alone were also evaluated.
   RESULTS: For each unit increase in the P55-14, the likelihood of having an ACS increased by 14% (95% confidence interval (CI) = 1.10, 1.18). Stratified analysis by Mediterranean diet adherence level revealed a similar association of PSS-14 with ACS likelihood between the low-to-moderate and moderate-to-high adherence groups (that is, odds ratio (OR) = 1.15, 95% CI = 1.09, 1.21 and OR = 1.13, 95% CI = 1.07, 1.80, respectively). Stress eating and eating alone were positively associated with the likelihood of having an ACS (OR = 1.31, 95% CI = 0.97, 1.77 and OR = 1.36, 95% CI = 1.08, 1.69, respectively). Eating heavy meals was not associated with ACS (OR = 1.08, 95% CI = 0.82, 1.41); no mediating or moderating effect of these behaviors on perceived stress ACS was observed.
   CONCLUSIONS: The highly significant impact of perceived stress On ACS likelihood was not mediated or moderated by the level of adherence to the Mediterranean diet or other eating behaviors, underlying the strong effect of this psychological disorder on ACS.
C1 [Katsarou, A.; Triposkiadis, F.; Skoularigis, J.] Univ Thessaly, Sch Med, Dept Cardiol, Larisa, Greece.
   [Papageorgiou, C.] Univ Athens, Eginit Hosp, Sch Med, Dept Psychiat 1, GR-11528 Athens, Greece.
   [Panagiotakos, D. B.] Univ Athens, Dept Nutr & Dietet, Athens, Greece.
C3 University of Thessaly; Athens Medical School; National & Kapodistrian
   University of Athens; National & Kapodistrian University of Athens
RP Panagiotakos, DB (corresponding author), Harokopio Univ, Dept Nutr & Dietet, 46 Paleon Polemiston St, Athens 16674, Greece.
EM d.b.panagiotakos@usa.net
RI Panagiotakos, Demosthenes/K-8294-2019
OI Papageorgiou, Charalabos/0000-0001-7635-1956; skoularigis,
   john/0000-0001-7159-2478
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NR 44
TC 3
Z9 4
U1 0
U2 13
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0954-3007
EI 1476-5640
J9 EUR J CLIN NUTR
JI Eur. J. Clin. Nutr.
PD SEP
PY 2014
VL 68
IS 9
BP 1016
EP 1021
DI 10.1038/ejcn.2014.74
PG 6
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nutrition & Dietetics
GA AO2PV
UT WOS:000341168600007
PM 24781691
OA Bronze
DA 2025-06-11
ER

PT J
AU Tarantino, G
   Citro, V
   Finelli, C
AF Tarantino, Giovanni
   Citro, Vincenzo
   Finelli, Carmine
TI What Non-Alcoholic Fatty Liver Disease Has Got to Do with Obstructive
   Sleep Apnoea Syndrome and viceversa?
SO JOURNAL OF GASTROINTESTINAL AND LIVER DISEASES
LA English
DT Review
DE non-alcoholic fatty liver disease (NAFLD); obstructive sleep apnoea
   syndrome (OSAS); body mass index (BMI)
ID POSITIVE AIRWAY PRESSURE; C-REACTIVE PROTEIN; CHRONIC INTERMITTENT
   HYPOXIA; NF-KAPPA-B; INSULIN-RESISTANCE; OXIDATIVE STRESS; ENDOTHELIAL
   DYSFUNCTION; METABOLIC SYNDROME; HEPATIC STEATOSIS; OBESE SUBJECTS
AB Non-alcoholic fatty liver disease (NAFLD) and obstructive sleep apnoea syndrome (OSAS) are common conditions, frequently encountered in patients with obesity and/or metabolic syndrome. NAFLD and OSAS are complex diseases that involve an interaction of several intertwined factors. Several lines of evidence lend credence to an immune system derangement in these patients, i.e. the low grade chronic inflammation status, reckoned to be the most important factor in causing and maintaining these two illnesses. Furthermore, it is emphasized the main role of spleen involvement, as a novel mechanism. In this review the contribution of the visceral adiposity in both NAFLD and OSAS is stressed as well as the role of intermittent hypoxia. Finally, a post on the prevention of systemic inflammation is made.
C1 [Tarantino, Giovanni] Univ Naples Federico II, Med Sch Naples, Dept Clin Med & Surg, Naples, Italy.
   [Tarantino, Giovanni] INT Fdn Pascale Canc Res Ctr Mercogliano, Mercogliano, AV, Italy.
   [Citro, Vincenzo] Umberto I Hosp, Dept Internal Med, Salerno, Italy.
   [Finelli, Carmine] Stella Maris Mediterraneum Fdn, Ctr Obes & Eating Disorders, Potenza, Italy.
C3 University of Naples Federico II; IRCCS Fondazione Stella Maris
RP Tarantino, G (corresponding author), Federico II Univ Med Sch Naples, Dept Clin Med & Surg, Naples, Italy.
EM tarantin@unina.it
RI Tarantino, Giovanni/AAW-2007-2021
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NR 103
TC 5
Z9 8
U1 0
U2 8
PU MEDICAL UNIV PRESS
PI CLUJ-NAPOCA
PA 3RD MEDICAL CLINIC, STR CROITORILOR NO 19-21, CLUJ-NAPOCA, 400162,
   ROMANIA
SN 1841-8724
EI 1842-1121
J9 J GASTROINTEST LIVER
JI J. Gastrointest. Liver Dis.
PD SEP
PY 2014
VL 23
IS 3
BP 291
EP 299
DI 10.1543/jgld.2014.1121.233.gvt
PG 9
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA AP9IT
UT WOS:000342394200014
PM 25267958
DA 2025-06-11
ER

PT J
AU Bernardes, N
   Dias, DD
   Stoyell-Conti, FF
   Brito-Monzani, JD
   Malfitano, C
   Caldini, EG
   Ulloa, L
   Llesuy, SF
   Irigoyen, MC
   De Angelis, K
AF Bernardes, Nathalia
   Dias, Danielle da Silva
   Stoyell-Conti, Filipe Fernandes
   Brito-Monzani, Janaina de Oliveira
   Malfitano, Christiane
   Caldini, Elia Garcia
   Ulloa, Luis
   Llesuy, Susana Francisca
   Irigoyen, Maria-Claudia
   De Angelis, Katia
TI Baroreflex Impairment Precedes Cardiometabolic Dysfunction in an
   Experimental Model of Metabolic Syndrome: Role of Inflammation and
   Oxidative Stress
SO SCIENTIFIC REPORTS
LA English
DT Article
ID INSULIN-RESISTANCE; HEART-RATE; FRUCTOSE; SENSITIVITY; HYPERTENSION;
   RISK; MECHANISMS; MORTALITY; OBESITY; CELLS
AB This study analyzes whether autonomic dysfunction precedes cardiometabolic alterations in spontaneously hypertensive rats (SHR) with fructose overload. Animals were randomly distributed into three groups: control, hypertensive and hypertensive with fructose overload. Fructose overload (100 g/L) was initiated at 30 days old, and the animals (n = 6/group/time) were evaluated after 7,15, 30 and 60 days of fructose consumption. Fructose consumption reduced baroreflex sensitivity by day 7, and still induced a progressive reduction in baroreflex sensitivity over the time. Fructose consumption also increased TNF alpha and IL-6 levels in the adipose tissue and IL-1 beta(3 levels in the spleen at days 15 and 30. Fructose consumption also reduced plasmatic nitrites (day 15 and 30) and superoxide dismutase activity (day 15 and 60), but increased hydrogen peroxide (day 30 and 60), lipid peroxidation and protein oxidation (day 60). Fructose consumption increased arterial pressure at day 30 (8%) and 60 (11%). Fructose consumption also induced a late insulin resistance at day 60, but did not affect glucose levels. In conclusion, the results show that baroreflex sensitivity impairment precedes inflammatory and oxidative stress disorders, probably by inducing hemodynamic and metabolic dysfunctions observed in metabolic syndrome.
C1 [Bernardes, Nathalia; Dias, Danielle da Silva; Stoyell-Conti, Filipe Fernandes; Brito-Monzani, Janaina de Oliveira; Malfitano, Christiane; De Angelis, Katia] Univ Nove Julho UNINOVE, Lab Translat Physiol, Sao Paulo, SP, Brazil.
   [Bernardes, Nathalia] Cidade Sao Paulo Univ UNICID, Lab Physiol & Metab, Sao Paulo, SP, Brazil.
   [Brito-Monzani, Janaina de Oliveira] Univ Fed Maranhao, Sao Luis, MA, Brazil.
   [Malfitano, Christiane] Fed Univ Lavras UFLA, Dept Hlth Sci, Lavras, MG, Brazil.
   [Bernardes, Nathalia; Caldini, Elia Garcia; Irigoyen, Maria-Claudia; De Angelis, Katia] Univ Sao Paulo, Heart Inst InCor, Hypertens Unit, Sao Paulo, SP, Brazil.
   [Ulloa, Luis] Rutgers State Univ, Rutgers New Jersey Med Sch, Ctr Immunol & Inflammat, Dept Surg, Newark, NJ USA.
   [Llesuy, Susana Francisca] Univ Buenos Aires, Dept Gen & Inorgan Chem, Buenos Aires, DF, Argentina.
   [De Angelis, Katia] Fed Univ Sao Paulo UNIFESP, Dept Physiol, Sao Paulo, SP, Brazil.
C3 Universidade Nove de Julho; Universidade Federal do Maranhao;
   Universidade Federal de Lavras; Universidade de Sao Paulo; Rutgers
   University System; Rutgers University Newark; Rutgers University New
   Brunswick; Rutgers University Biomedical & Health Sciences; University
   of Buenos Aires; Universidade Federal de Sao Paulo (UNIFESP)
RP De Angelis, K (corresponding author), Univ Nove Julho UNINOVE, Lab Translat Physiol, Sao Paulo, SP, Brazil.; De Angelis, K (corresponding author), Univ Sao Paulo, Heart Inst InCor, Hypertens Unit, Sao Paulo, SP, Brazil.; De Angelis, K (corresponding author), Fed Univ Sao Paulo UNIFESP, Dept Physiol, Sao Paulo, SP, Brazil.
EM prof.kangelis@yahoo.com.br
RI Bernardes, Nathalia/L-7460-2015; Malfitano, Christiane/I-2701-2013;
   Ulloa, Luis/AAE-8751-2019; da Silva Dias, Danielle/AAN-7618-2020;
   Irigoyen, maria Claudia/N-6880-2014; Caldini, Elia Garcia/F-1105-2011;
   DE ANGELIS, KATIA/I-6098-2016
OI Irigoyen, maria Claudia/0000-0003-2097-3662; Caldini, Elia
   Garcia/0000-0001-5322-3812; DE ANGELIS, KATIA/0000-0002-3640-9049;
   Ulloa, Luis/0000-0002-7702-7549
FU CNPq [457200/2014-6, 309292/2014-0]; FAPESP [2018/06872-3,
   2015/11223-6]; CAPES [88881.062178/2014-01]; CNPq Fellowship (CNPq-BPQ)
FX This study was supported by CNPq (457200/2014-6; 309292/2014-0) and
   FAPESP (2018/06872-3; 2015/11223-6); CAPES (88881.062178/2014-01). Katia
   De Angelis and Maria-Claudia Irigoyen are recipients of CNPq Fellowship
   (CNPq-BPQ).
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NR 47
TC 17
Z9 17
U1 0
U2 2
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD JUN 5
PY 2018
VL 8
AR 8578
DI 10.1038/s41598-018-26816-4
PG 10
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA GI1HZ
UT WOS:000434122600003
PM 29872081
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Thomas, JJ
   Ren, J
AF Thomas, Joi J.
   Ren, Jun
TI Obstructive sleep apnoea and cardiovascular complications: perception
   versus knowledge
SO CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
LA English
DT Review
DE cardiovascular disease; obstructive sleep apnoea; risk factor
ID CHRONIC INTERMITTENT HYPOXIA; FATTY LIVER-DISEASE; POSITIVE AIRWAY
   PRESSURE; EXCESSIVE DAYTIME SLEEPINESS; RANDOMIZED CONTROLLED-TRIAL;
   CORONARY-ARTERY-DISEASE; NECROSIS-FACTOR-ALPHA; METABOLIC SYNDROME;
   HEART-FAILURE; SYMPATHETIC ACTIVITY
AB 1. Epidemiological evidence has confirmed that obstructive sleep apnoea (OSA) significantly promotes cardiovascular risk, independent of age, sex, race and other common risk factors for cardiovascular diseases, such as smoking, drinking, obesity, diabetes mellitus, dyslipidaemia and hypertension.
   2. Patients with severe OSA exhibit a higher prevalence of coronary artery disease, heart failure and stroke. Despite the tight correlation between sleep apnoea and these comorbidities, the mechanisms behind increased cardiovascular risk in OSA remain elusive. Several theories have been postulated, including sympathetic activation, endothelial dysfunction, oxidative stress and inflammation.
   3. The association between OSA and cardiovascular diseases may be rather complicated and compounded by the presence of components of metabolic syndrome, such as obesity, hypertension, diabetes mellitus and dyslipidaemia. The present minireview updates current knowledge with regard to the cardiovascular sequelae of OSA and the mechanisms involved.
C1 [Thomas, Joi J.; Ren, Jun] Univ Wyoming, Coll Hlth Sci, Div Kinesiol & Hlth & Biomed Sci, Laramie, WY 82071 USA.
C3 University of Wyoming
RP Ren, J (corresponding author), Univ Wyoming, Coll Hlth Sci, Div Kinesiol & Hlth & Biomed Sci, Laramie, WY 82071 USA.
EM jren@uwyo.edu
RI Ren, Jun/ACG-5366-2022
OI Ren, Jun/0000-0002-0275-0783
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NR 100
TC 25
Z9 27
U1 1
U2 18
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1440-1681
J9 CLIN EXP PHARMACOL P
JI Clin. Exp. Pharmacol. Physiol.
PD DEC
PY 2012
VL 39
IS 12
BP 995
EP 1003
DI 10.1111/1440-1681.12024
PG 9
WC Pharmacology & Pharmacy; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Physiology
GA 044IK
UT WOS:000311612600002
PM 23082844
DA 2025-06-11
ER

PT J
AU Menikdiwela, KR
   Ramalingam, L
   Rasha, F
   Wang, S
   Dufour, JM
   Kalupahana, NS
   Sunahara, KKS
   Martins, JO
   Moustaid-Moussa, N
AF Menikdiwela, Kalhara R.
   Ramalingam, Latha
   Rasha, Fahmida
   Wang, Shu
   Dufour, Jannette M.
   Kalupahana, Nishan S.
   Sunahara, Karen K. S.
   Martins, Joilson O.
   Moustaid-Moussa, Naima
TI Autophagy in metabolic syndrome: breaking the wheel by targeting the
   renin-angiotensin system
SO CELL DEATH & DISEASE
LA English
DT Review
ID ENDOPLASMIC-RETICULUM STRESS; ADIPOSE-TISSUE MACROPHAGES; INDUCED
   INSULIN-RESISTANCE; ACTIVATED RECEPTOR-GAMMA; PANCREATIC BETA-CELL;
   OXIDATIVE STRESS; BLOOD-PRESSURE; CARDIOMYOCYTE AUTOPHAGY; DEFECTIVE
   REGULATION; MOLECULAR MACHINERY
AB Metabolic syndrome (MetS) is a complex, emerging epidemic which disrupts the metabolic homeostasis of several organs, including liver, heart, pancreas, and adipose tissue. While studies have been conducted in these research areas, the pathogenesis and mechanisms of MetS remain debatable. Lines of evidence show that physiological systems, such as the renin-angiotensin system (RAS) and autophagy play vital regulatory roles in MetS. RAS is a pivotal system known for controlling blood pressure and fluid balance, whereas autophagy is involved in the degradation and recycling of cellular components, including proteins. Although RAS is activated in MetS, the interrelationship between RAS and autophagy varies in glucose homeostatic organs and their cross talk is poorly understood. Interestingly, autophagy is attenuated in the liver during MetS, whereas autophagic activity is induced in adipose tissue during MetS, indicating tissue-specific discordant roles. We discuss in vivo and in vitro studies conducted in metabolic tissues and dissect their tissue-specific effects. Moreover, our review will focus on the molecular mechanisms by which autophagy orchestrates MetS and the ways future treatments could target RAS in order to achieve metabolic homeostasis.
C1 [Menikdiwela, Kalhara R.; Ramalingam, Latha; Rasha, Fahmida; Wang, Shu; Kalupahana, Nishan S.; Moustaid-Moussa, Naima] Texas Tech Univ, Dept Nutr Sci, Lubbock, TX 79409 USA.
   [Menikdiwela, Kalhara R.; Ramalingam, Latha; Rasha, Fahmida; Wang, Shu; Dufour, Jannette M.; Kalupahana, Nishan S.; Moustaid-Moussa, Naima] Texas Tech Univ, Obes Res Inst, Lubbock, TX 79409 USA.
   [Dufour, Jannette M.] Texas Tech Univ, Dept Cell Biol & Biochem, Hlth Sci Ctr, Lubbock, TX 79409 USA.
   [Kalupahana, Nishan S.] Univ Peradeniya, Fac Med, Dept Physiol, Peradeniya, Sri Lanka.
   [Sunahara, Karen K. S.] Univ Sao Paulo, Dept Expt Physiopathol, Med Sch, Sao Paulo, Brazil.
   [Martins, Joilson O.] Univ Sao Paulo FCF USP, Dept Clin & Toxicol Anal, Lab Immunoendocrinol, Sch Pharmaceut Sci, Sao Paulo, Brazil.
C3 Texas Tech University System; Texas Tech University; Texas Tech
   University System; Texas Tech University; Texas Tech University System;
   Texas Tech University Health Sciences Center Lubbock; University of
   Peradeniya; Universidade de Sao Paulo; Universidade de Sao Paulo
RP Moustaid-Moussa, N (corresponding author), Texas Tech Univ, Dept Nutr Sci, Lubbock, TX 79409 USA.; Moustaid-Moussa, N (corresponding author), Texas Tech Univ, Obes Res Inst, Lubbock, TX 79409 USA.
EM naima.moustaid-moussa@ttu.edu
RI Kalupahana, Nishan/E-1913-2011; Ramalingam, Latha/M-8438-2015; Martins,
   Joilson O./G-4367-2011; Moustaid-Moussa, Naima/B-9067-2014
OI Martins, Joilson O./0000-0003-2630-7038; Wang, Shu/0000-0001-8078-9942;
   Sunahara, Karen/0000-0003-2513-0840; Rasha, Fahmida
   Akter/0000-0003-1369-3806; Ramalingam, Latha/0000-0002-4856-7327;
   Moustaid-Moussa, Naima/0000-0002-7508-8030
FU SPRINT award (Texas Tech University); SPRINT award (FAPESP)
FX This work was supported in part by a SPRINT award (Texas Tech University
   and FAPESP agreement) to N.M.M., L.R. and J.O.M.
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NR 168
TC 64
Z9 70
U1 0
U2 9
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 2041-4889
J9 CELL DEATH DIS
JI Cell Death Dis.
PD FEB 3
PY 2020
VL 11
IS 2
DI 10.1038/s41419-020-2275-9
PG 17
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA KI5OB
UT WOS:000511398100009
PM 32015340
OA Green Published, gold
DA 2025-06-11
ER

PT S
AU Cerdá, C
   Sánchez, C
   Climent, B
   Vázquez, A
   Iradi, A
   El Amrani, F
   Bediaga, A
   Sáez, GT
AF Cerda, Concha
   Sanchez, Carlos
   Climent, Benjamin
   Vazquez, Antonio
   Iradi, Antonio
   El Amrani, Fatima
   Bediaga, Ana
   Saez, Guillermo T.
BE Camps, J
TI Oxidative Stress and DNA Damage in Obesity-Related Tumorigenesis
SO OXIDATIVE STRESS AND INFLAMMATION IN NON-COMMUNICABLE DISEASES -
   MOLECULAR MECHANISMS AND PERSPECTIVES IN THERAPEUTICS
SE Advances in Experimental Medicine and Biology
LA English
DT Article; Book Chapter
DE Cancer; DNA damage; Free radicals; Obesity
ID BODY-MASS INDEX; BREAST-CANCER CELLS; FACTOR-KAPPA-B; METABOLIC
   SYNDROME; GROWTH-FACTOR; COLON-CANCER; HIGH-FAT; CALORIC RESTRICTION;
   ENDOMETRIAL CANCER; INSULIN-RESISTANCE
AB Reactive oxygen species induce oxidative modification of critical macromolecules. Oxygen derived free radicals may act as potential cytotoxic intermediates inducing inflammatory and degenerative processes, or as signal messengers for the regulation of gene expression. This dual effect mainly depends on the availability of free radicals in terms of concentration, as well as on the environmental characteristics in which they are produced. The formation of free radicals has been proposed to be the linking factor between certain metabolic disturbances and cancer. Circulating mononuclear cells of patients with high cholesterol levels, insulin resistance, metabolic syndrome or obesity present lower levels of antioxidant enzymes and increased concentrations of oxidative stress by-products such as isoprostanes or the DNA oxidized and highly mutagenic base 8-oxo-7,8-dihydro-2 '-deoxyguanosine. Overweight or obese subjects also exhibit hormonal changes as a consequence of the increase of mass fat, and these hormonal alterations have been implicated in the alteration of different signal transduction mechanisms and in cell growth and differentiation. A significant correlation has been found between body mass index and cancer. The biological factors and molecular mechanisms implicated in obesity associated cancer susceptibility will be reviewed.
C1 [Cerda, Concha; Bediaga, Ana] Univ Valencia, Gen Univ Hosp CIBEROBN, Oxidat Stress Commiss SEQC, Serv Clin Anal CDB, Valencia, Spain.
   [Sanchez, Carlos] Univ Valencia, Gen Univ Hosp, Endocrinol & Nutr Unit, Valencia, Spain.
   [Climent, Benjamin] Univ Valencia, Gen Univ Hosp, Serv Internal Med, Valencia, Spain.
   [Vazquez, Antonio] Univ Valencia, Gen Univ Hosp, Serv Gen & Digest Surg, Valencia, Spain.
   [Iradi, Antonio] Univ Valencia, Fac Med CIBEROBN, Dept Physiol, Valencia, Spain.
   [El Amrani, Fatima] Univ Valencia, Fac Med, Dept Biochem & Mol Biol, Valencia 46010, Spain.
   Univ Valencia, Gen Univ Hosp CIBEROBN, Oxidat Stress Commiss SEQC, Serv Clin Analy CDB, Valencia, Spain.
   [Saez, Guillermo T.] Univ Valencia, Oxidat Stress Commiss SEQC, Gen Univ Hosp CDB, Dept Biochem & Mol Biol,Fac Med, Valencia 46010, Spain.
C3 CIBER - Centro de Investigacion Biomedica en Red; CIBEROBN; University
   of Valencia; University of Valencia; University of Valencia; University
   of Valencia; University of Valencia; CIBER - Centro de Investigacion
   Biomedica en Red; CIBEROBN; University of Valencia; University of
   Valencia; CIBER - Centro de Investigacion Biomedica en Red; CIBEROBN;
   University of Valencia
RP Sáez, GT (corresponding author), Univ Valencia, Gen Univ Hosp CIBEROBN, Oxidat Stress Commiss SEQC, Serv Clin Analy CDB, Valencia, Spain.
EM Concermi@gmail.com; Carlos.sanchez@uv.es; Climent_ben@gva.es;
   Vprado.a@gmail.com; Antonio.iradi@uv.es; Yolanda.ben@uv.es;
   anbecol@hotmail.com; Guillermo.saez@uv.es
RI ; Sanchez Juan, Carlos/A-2197-2019
OI Saez, Guillermo/0000-0002-8164-4048; Sanchez Juan,
   Carlos/0000-0002-0319-0722
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NR 97
TC 48
Z9 52
U1 0
U2 16
PU SPRINGER INTERNATIONAL PUBLISHING AG
PI CHAM
PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND
SN 0065-2598
EI 2214-8019
BN 978-3-319-07320-0; 978-3-319-07319-4
J9 ADV EXP MED BIOL
JI Adv.Exp.Med.Biol.
PY 2014
VL 824
BP 5
EP 17
DI 10.1007/978-3-319-07320-0_2
D2 10.1007/978-3-319-07320-0
PG 13
WC Biochemistry & Molecular Biology; Medicine, Research & Experimental;
   Pathology
WE Book Citation Index – Science (BKCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Research & Experimental Medicine;
   Pathology
GA BB8GE
UT WOS:000346519700002
PM 25038989
DA 2025-06-11
ER

PT J
AU Molinar-Toribio, E
   Pérez-Jiménez, J
   Ramos-Romero, S
   Lluís, L
   Sánchez-Martos, V
   Taltavull, N
   Romeu, M
   Pazos, M
   Méndez, L
   Miranda, A
   Cascante, M
   Medina, I
   Torres, JL
AF Molinar-Toribio, Eunice
   Perez-Jimenez, Jara
   Ramos-Romero, Sara
   Lluis, Laura
   Sanchez-Martos, Vanessa
   Taltavull, Nuria
   Romeu, Marta
   Pazos, Manuel
   Mendez, Lucia
   Miranda, Anibal
   Cascante, Marta
   Medina, Isabel
   Lluis Torres, Josep
TI Cardiovascular Disease-Related Parameters and Oxidative Stress in SHROB
   Rats, a Model for Metabolic Syndrome
SO PLOS ONE
LA English
DT Article
ID MESENTERIC RESISTANCE ARTERIES; INSULIN-RESISTANCE; NONSENSE MUTATION;
   LEPTIN RECEPTOR; KOLETSKY RATS; PROTEIN; FAT; INFLAMMATION; GLUTATHIONE;
   CATALASE
AB SHROB rats have been suggested as a model for metabolic syndrome (MetS) as a situation prior to the onset of CVD or type-2 diabetes, but information on descriptive biochemical parameters for this model is limited. Here, we extensively evaluate parameters related to CVD and oxidative stress (OS) in SHROB rats. SHROB rats were monitored for 15 weeks and compared to a control group of Wistar rats. Body weight was recorded weekly. At the end of the study, parameters related to CVD and OS were evaluated in plasma, urine and different organs. SHROB rats presented statistically significant differences from Wistar rats in CVD risk factors: total cholesterol, LDL-cholesterol, triglycerides, apoA1, apoB100, abdominal fat, insulin, blood pressure, C-reactive protein, ICAM-1 and PAI-1. In adipose tissue, liver and brain, the endogenous antioxidant systems were activated, yet there was no significant oxidative damage to lipids (MDA) or proteins (carbonylation). We conclude that SHROB rats present significant alterations in parameters related to inflammation, endothelial dysfunction, thrombotic activity, insulin resistance and OS measured in plasma as well as enhanced redox defence systems in vital organs that will be useful as markers of MetS and CVD for nutrition interventions.
C1 [Molinar-Toribio, Eunice; Perez-Jimenez, Jara; Ramos-Romero, Sara; Lluis Torres, Josep] CSIC, IQAC, Inst Adv Chem Catalonia, Barcelona, Spain.
   [Ramos-Romero, Sara] CIBER BBN, Biomed Res Networking Ctr Bioengn Biomat & Nanome, Zaragoza, Spain.
   [Lluis, Laura; Sanchez-Martos, Vanessa; Taltavull, Nuria; Romeu, Marta] Univ Rovira & Virgili, Fac Med & Ciencias Salut, Unidad Farmacol, E-43201 Reus, Spain.
   [Pazos, Manuel; Mendez, Lucia; Medina, Isabel] CSIC, IIM, Vigo, Spain.
   [Miranda, Anibal; Cascante, Marta] Univ Barcelona, Fac Biol, IBUB, Dept Biochem & Mol Biol, Barcelona, Spain.
   [Miranda, Anibal; Cascante, Marta] Univ Barcelona, Fac Biol, Unit Associated CSIC, Barcelona, Spain.
   [Miranda, Anibal; Cascante, Marta] Inst Invest Biomed August Pi & Sunyer IDIBAPS, Barcelona, Spain.
C3 Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Centro de
   Investigacion y Desarrollo Pascual Vila (CID-CSIC); CSIC - Instituto de
   Quimica Avanzada de Cataluna (IQAC); CIBER - Centro de Investigacion
   Biomedica en Red; CIBERBBN; Universitat Rovira i Virgili; Consejo
   Superior de Investigaciones Cientificas (CSIC); CSIC - Instituto de
   Investigaciones Marinas (IIM); University of Barcelona; University of
   Barcelona; Consejo Superior de Investigaciones Cientificas (CSIC);
   University of Barcelona; Hospital Clinic de Barcelona; IDIBAPS
RP Pérez-Jiménez, J (corresponding author), CSIC, IQAC, Inst Adv Chem Catalonia, Barcelona, Spain.
EM jara.perez@ictan.csic.es
RI CASCANTE, MARTA/AFK-5991-2022; ROMEU, MARTA/O-7129-2019; Ramos-Romero,
   Sara/AAH-6209-2020; MEDINA, ISABEL/AAL-4012-2021; Perez-Jimenez,
   Jara/B-3989-2009; Torres, Josep/N-7256-2013; Pazos, Manuel/N-5007-2014;
   Ramos-Romero, Sara/K-8301-2017; Mendez, Lucia/T-7016-2017; ROMEU,
   MARTA/A-8468-2014
OI Torres, Josep/0000-0002-5072-8265; Molinar-Toribio,
   Eunice/0000-0001-8870-6849; Pazos, Manuel/0000-0003-1571-5730; MEDINA,
   ISABEL/0000-0002-1854-3359; Ramos-Romero, Sara/0000-0002-9293-4454;
   Taltavull, Nuria/0000-0002-3340-2650; Mendez, Lucia/0000-0002-9711-2994;
   CASCANTE, MARTA/0000-0002-2062-4633; ROMEU, MARTA/0000-0002-2131-1858;
   Perez-Jimenez, Jara/0000-0002-2811-4558
FU Spanish Ministries of Science and Innovation and of Economy and
   Competitiveness [AGL2009-12374-C03-01, AGL2009-12374-C03-02,
   AGL2009-12374-C03-03, AGL2013-49079-C2-1-R, AGL2013-49079-C2-2-R];
   Generalitat de Catalunya regional authorities [2009SGR-1308]; European
   Union [FP7-KBBE-222639]; ICREA Foundation of the Generalitat de
   Catalunya; Panamanian Government (SENACYT/IFRHU); Spanish Ministry of
   Science and Innovation; ISCIII; Xunta de Galicia [CD09/00068]
FX This research was supported by the Spanish Ministries of Science and
   Innovation and of Economy and Competitiveness (Grants
   AGL2009-12374-C03-01, -02 and -03; AGL2013-49079-C2-1,2-R; respectively)
   and in part by the Generalitat de Catalunya regional authorities
   (2009SGR-1308). M. C. acknowledges ETHERPATHS (FP7-KBBE-222639) funded
   by the European Union and "ICREA Academia'' award for excellence in
   research, funded by the ICREA Foundation of the Generalitat de
   Catalunya. The Panamanian Government (SENACYT/IFRHU) and the Spanish
   Ministry of Science and Innovation awarded graduate fellowships to E.
   M.-T. and L. M., respectively. The ISCIII and the Xunta de Galicia are
   also acknowledged for "Sara Borrell'' and "Isidro Parga Pondal''
   postdoctoral contracts to J.P.-J. (CD09/00068) and M. P., respectively.
   The funders had no role in study design, data collection and analysis,
   decision to publish, or preparation of the manuscript.
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NR 44
TC 16
Z9 16
U1 0
U2 19
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD AUG 12
PY 2014
VL 9
IS 8
AR e104637
DI 10.1371/journal.pone.0104637
PG 8
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA AO3LJ
UT WOS:000341230400064
PM 25115868
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Wong, SK
AF Wong, Sok Kuan
TI Repurposing New Use for Old Drug Chloroquine against Metabolic Syndrome:
   A Review on Animal and Human Evidence
SO INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
LA English
DT Review
DE diabetes; dyslipidaemia; hypertension; immunomodulation; inflammation;
   obesity
ID SYSTEMIC-LUPUS-ERYTHEMATOSUS; TYPE-2 DIABETES-MELLITUS;
   RHEUMATOID-ARTHRITIS; ENDOTHELIAL DYSFUNCTION; HYDROXYCHLOROQUINE USE;
   INSULIN SENSITIVITY; VIRUS-REPLICATION; LIPID PROFILE; DOUBLE-BLIND;
   RISK
AB Chloroquine (CQ) and hydroxychloroquine (HCQ) are traditional anti-malarial drugs that have been repurposed for new therapeutic uses in many diseases due to their simple usage and cost-effectiveness. The pleiotropic effects of CQ and HCQ in regulating blood pressure, glucose homeostasis, lipid, and carbohydrate metabolism have been previously described in vivo and in humans, thus suggesting their role in metabolic syndrome (MetS) prevention. The anti-hyperglycaemic, anti-hyperlipidaemic, cardioprotective, anti-hypertensive, and anti-obesity effects of CQ and HCQ might be elicited through reduction of inflammatory response and oxidative stress, improvement of endothelial function, activation of insulin signalling pathway, inhibition of lipogenesis and autophagy, as well as regulation of adipokines and apoptosis. In conclusion, the current state of knowledge supported the repurposing of CQ and HCQ usage in the management of MetS.
C1 [Wong, Sok Kuan] Univ Kebangsaan Malaysia, Fac Med, Dept Pharmacol, Jalan Yaacob Latif, Kuala Lumpur 56000, Malaysia.
C3 Universiti Kebangsaan Malaysia
RP Wong, SK (corresponding author), Univ Kebangsaan Malaysia, Fac Med, Dept Pharmacol, Jalan Yaacob Latif, Kuala Lumpur 56000, Malaysia.
EM jocylnwsk@gmail.com
RI Wong, Sok/I-1243-2016
FU Universiti Kebangsaan Malaysia [FF-2020-366]
FX The author would like to thank Universiti Kebangsaan Malaysia for the
   support via FF-2020-366 grant.
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NR 110
TC 20
Z9 21
U1 0
U2 5
PU IVYSPRING INT PUBL
PI LAKE HAVEN
PA PO BOX 4546, LAKE HAVEN, NSW 2263, AUSTRALIA
SN 1449-1907
J9 INT J MED SCI
JI Int. J. Med. Sci.
PY 2021
VL 18
IS 12
BP 2673
EP 2688
DI 10.7150/ijms.58147
PG 16
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA TD0CW
UT WOS:000669005200004
PM 34104100
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Kant, S
   Standen, CL
   Morel, C
   Jung, DY
   Kim, JK
   Swat, W
   Flavell, RA
   Davis, RJ
AF Kant, Shashi
   Standen, Claire L.
   Morel, Caroline
   Jung, Dae Young
   Kim, Jason K.
   Swat, Wojciech
   Flavell, Richard A.
   Davis, Roger J.
TI A Protein Scaffold Coordinates SRC-Mediated JNK Activation in Response
   to Metabolic Stress
SO CELL REPORTS
LA English
DT Article
ID MAP KINASE ACTIVATION; SIGNAL-TRANSDUCTION; INSULIN-RESISTANCE; FAMILY
   KINASES; ADIPOSE-TISSUE; PATHWAY; OBESITY; REQUIREMENT; VAV;
   IDENTIFICATION
AB Obesity is a major risk factor for the development of metabolic syndrome and type 2 diabetes. How obesity contributes to metabolic syndrome is unclear. Free fatty acid (FFA) activation of a non-receptor tyrosine kinase (SRC)-dependent cJun NH2-terminal kinase (JNK) signaling pathway is implicated in this process. However, the mechanism that mediates SRC-dependent JNK activation is unclear. Here, we identify a role for the scaffold protein JIP1 in SRC-dependent JNK activation. SRC phosphorylation of JIP1 creates phosphotyrosine interaction motifs that bind the SH2 domains of SRC and the guanine nucleotide exchange factor VAV. These interactions are required for SRC-induced activation of VAV and the subsequent engagement of a JIP1-tethered JNK signaling module. The JIP1 scaffold protein, therefore, plays a dual role in FFA signaling by coordinating upstream SRC functions together with downstream effector signaling by the JNK pathway.
C1 [Kant, Shashi; Standen, Claire L.; Morel, Caroline; Jung, Dae Young; Kim, Jason K.; Davis, Roger J.] Univ Massachusetts, Sch Med, Program Mol Med, Worcester, MA 01605 USA.
   [Kant, Shashi] Univ Massachusetts, Sch Med, Dept Med, Div Cardiovasc Med, Worcester, MA 01605 USA.
   [Kim, Jason K.] Univ Massachusetts, Sch Med, Dept Med, Div Endocrinol Metab & Diabet, Worcester, MA 01605 USA.
   [Swat, Wojciech] Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63110 USA.
   [Flavell, Richard A.] Yale Univ, Sch Med, Howard Hughes Med Inst, 333 Cedar St, New Haven, CT 06520 USA.
   [Flavell, Richard A.] Yale Univ, Sch Med, Dept Immunobiol, 333 Cedar St, New Haven, CT 06520 USA.
   [Davis, Roger J.] Howard Hughes Med Inst, Worcester, MA 01605 USA.
C3 University of Massachusetts System; University of Massachusetts
   Worcester; University of Massachusetts System; University of
   Massachusetts Worcester; University of Massachusetts System; University
   of Massachusetts Worcester; Washington University (WUSTL); Howard Hughes
   Medical Institute; Yale University; Yale University; Howard Hughes
   Medical Institute
RP Kant, S; Davis, RJ (corresponding author), Univ Massachusetts, Sch Med, Program Mol Med, Worcester, MA 01605 USA.; Kant, S (corresponding author), Univ Massachusetts, Sch Med, Dept Med, Div Cardiovasc Med, Worcester, MA 01605 USA.; Davis, RJ (corresponding author), Howard Hughes Med Inst, Worcester, MA 01605 USA.
EM shashi.kant@umassmed.edu; roger.davis@umassmed.edu
RI Flavell, Richard/ACH-3245-2022; Kant, Shashi/B-1585-2016
OI Davis, Roger/0000-0002-0130-1652; Kant, Shashi/0000-0001-8772-6813; Kim,
   Jason/0000-0002-7185-042X
FU NIH [DK107220, DK112698, DK093000]; American Heart Association
   [16SDG29660007]; American Heart Association (AHA) [16SDG29660007]
   Funding Source: American Heart Association (AHA)
FX We thank Vicky Benoit and Heather Learnard for expert technical
   assistance and Kathy Gemme for administrative assistance. These studies
   were supported by NIH grants DK107220 and DK112698 (to R.J.D.) and
   American Heart Association grant 16SDG29660007 (to S.K.). The UMASS
   Mouse Metabolic Phenotyping Center is supported by NIH grant DK093000
   (to J.K.K.). R.A.F. and R.J.D. are investigators of the Howard Hughes
   Medical Institute.
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NR 45
TC 31
Z9 33
U1 0
U2 6
PU CELL PRESS
PI CAMBRIDGE
PA 50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA
SN 2211-1247
J9 CELL REP
JI Cell Reports
PD SEP 19
PY 2017
VL 20
IS 12
BP 2775
EP 2783
DI 10.1016/j.celrep.2017.08.025
PG 9
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA FH4LZ
UT WOS:000411127400004
PM 28930674
OA Green Published, gold, Green Accepted
DA 2025-06-11
ER

PT J
AU Meadows, JL
   Vaughan, DE
AF Meadows, Judith L.
   Vaughan, Douglas E.
TI Endothelial biology in the post-menopausal obese woman
SO MATURITAS
LA English
DT Review
DE Endothelial function; Nitric oxide; Vasodilation; Menopause; Gender;
   Vascular function; Cardiovascular disease; Obesity; Aging; Metabolic
   syndrome
ID PLASMINOGEN ACTIVATOR RELEASE; OBSTRUCTIVE SLEEP-APNEA; ESTROGEN PLUS
   PROGESTIN; METABOLIC SYNDROME; INSULIN-RESISTANCE; DEPENDENT
   VASODILATION; OXIDATIVE STRESS; HORMONE-THERAPY; CARDIOVASCULAR-DISEASE;
   VASCULAR-DISEASE
AB Women generally have a reduced risk of cardiovascular disease (CVD). However, this protection of gender diminishes rapidly after menopause and with advancing age, particularly in obese women. Alterations in vascular function are thought to a key early step in the development of atherosclerosis. In this review, we will describe the features of endothelial dysfunction in the post-menopausal obese female and discuss the interplay of aging, estrogen withdrawal, and obesity. The objectives include (1) a review of endothelial biology and endothelial dysfunction, and (2) a discussion how the endothelial function is altered in the context of aging, hormonal changes and insulin resistance. The clinical consequences of endothelial dysfunction and CVD will also be reviewed. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
C1 [Meadows, Judith L.; Vaughan, Douglas E.] NW Univ Feinberg, Sch Med, Dept Med, Div Cardiol, Chicago, IL 60611 USA.
C3 Northwestern University; Feinberg School of Medicine
RP Vaughan, DE (corresponding author), NW Univ Feinberg, Sch Med, Dept Med, Div Cardiol, Chicago, IL 60611 USA.
EM d-vaughan@northwestern.edu
FU National Institutes of Health, Bethesda, MD [HL51387, P50 HL 081009]
FX This work was supported in part by grants HL51387 and P50 HL 081009 from
   the National Institutes of Health, Bethesda, MD.
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NR 69
TC 17
Z9 20
U1 0
U2 5
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0378-5122
EI 1873-4111
J9 MATURITAS
JI Maturitas
PD JUN
PY 2011
VL 69
IS 2
BP 120
EP 125
DI 10.1016/j.maturitas.2011.03.012
PG 6
WC Geriatrics & Gerontology; Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology; Obstetrics & Gynecology
GA 780EP
UT WOS:000291837600006
PM 21530115
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Rodríguez-Vera, D
   Vergara-Castañeda, A
   Lazcano-Orozco, DK
   Ramírez-Vélez, G
   Vivar-Sierra, A
   Araiza-Macías, MJ
   Hernández-Contreras, JP
   Naranjo-Navarro, CR
   Salazar, JR
   Loza-Mejía, MA
   Pinto-Almazán, R
AF Rodriguez-Vera, Diana
   Vergara-Castaneda, Arely
   Lazcano-Orozco, Diana K.
   Ramirez-Velez, Gabriela
   Vivar-Sierra, Alonso
   Jose Araiza-Macias, Maria
   Patricio Hernandez-Contreras, Jose
   Rogelio Naranjo-Navarro, Carlos
   Rodrigo Salazar, Juan
   Loza-Mejia, Marco A.
   Pinto-Almazan, Rodolfo
TI Inflammation Parameters Associated with Metabolic Disorders:
   Relationship Between Diet and Microbiota
SO METABOLIC SYNDROME AND RELATED DISORDERS
LA English
DT Article
DE metabolic syndrome; obesity; hypertension; insulin resistance;
   microbiota; diet
ID C-REACTIVE PROTEIN; HYPERTENSION DASH DIET; NECROSIS-FACTOR-ALPHA;
   ADIPOSE-TISSUE; INSULIN-RESISTANCE; GUT MICROBIOTA; ENDOTHELIAL
   FUNCTION; MEDITERRANEAN DIET; OXIDATIVE STRESS; CARDIOVASCULAR RISK
AB The metabolic syndrome (MetS) includes numerous interrelated clinical, anthropometric, biochemical, and metabolic components and has become a public health problem due to its impact on morbimortality. Inflammation is a central mechanism underlying the etiology and clinical manifestations of MetS, contributing to its related pathological outcomes. Dietary patterns have been associated with the promotion of the diversity of microbiota in the digestive tract. Recently, research has focused on the importance of microbiota changes associated with MetS and inflammation. Other studies have been performed to understand the impact of prebiotics, probiotics, and synbiotics as allies on diet, inflammation, and MetS parameters. This review analyses the correlation between metabolic disorders, inflammation parameters, gut microbiota, and how diet has been involved as treatment of MetS and the modulation of inflammation and microbiota.
C1 [Rodriguez-Vera, Diana; Lazcano-Orozco, Diana K.; Pinto-Almazan, Rodolfo] High Specialty Reg Hosp Ixtapaluca HRAEI, Res Unit, Mol Biol Metab & Neurodegenerat Dis Lab, Carretera Fed Mexico Puebla Km 34-5, Ixtapaluca 56530, Mexico.
   [Rodriguez-Vera, Diana; Pinto-Almazan, Rodolfo] Inst Politecn Nacl, Escuela Super Med, Secc Estudios Posgrad & Invest, Mexico City, DF, Mexico.
   [Vergara-Castaneda, Arely] Univ La Salle Mexico, Chem Sci Sch, Basic & Clin Hlth Sci Res Grp, Mexico City, DF, Mexico.
   [Ramirez-Velez, Gabriela; Vivar-Sierra, Alonso; Jose Araiza-Macias, Maria; Patricio Hernandez-Contreras, Jose; Rogelio Naranjo-Navarro, Carlos; Rodrigo Salazar, Juan; Loza-Mejia, Marco A.] Univ La Salle Mexico, Chem Sci Sch, Design Isolat & Synth Bioact Mol Res Grp, Benjamin Franklin 45, Mexico City 06140, DF, Mexico.
C3 Instituto Politecnico Nacional - Mexico
RP Pinto-Almazán, R (corresponding author), High Specialty Reg Hosp Ixtapaluca HRAEI, Res Unit, Mol Biol Metab & Neurodegenerat Dis Lab, Carretera Fed Mexico Puebla Km 34-5, Ixtapaluca 56530, Mexico.; Loza-Mejía, MA (corresponding author), Univ La Salle Mexico, Chem Sci Sch, Design Isolat & Synth Bioact Mol Res Grp, Benjamin Franklin 45, Mexico City 06140, DF, Mexico.
RI Vergara-Castañeda, Arely/IUN-2401-2023; Ramírez-Vélez,
   Robinson/D-5311-2016; Loza-Mejia, Marco A./F-3557-2019; Pinto-Almazan,
   Rodolfo/F-3483-2013
OI Vivar-Sierra, Alonso/0000-0002-9267-2669; VERGARA-CASTANEDA,
   ARELY/0000-0002-9366-3211; Loza-Mejia, Marco A./0000-0002-8449-0806;
   Pinto-Almazan, Rodolfo/0000-0002-5210-5395
FU Doctorate Degree in Medicine Research Program
FX This work was submitted in partial fulfillment of the requirements for
   the PhD degree of D.R.-V. at the Doctorate Degree in Medicine Research
   Program.
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NR 135
TC 6
Z9 6
U1 0
U2 7
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-4196
EI 1557-8518
J9 METAB SYNDR RELAT D
JI Metab. Syndr. Relat. Disord.
PD NOV 1
PY 2021
VL 19
IS 9
BP 469
EP 482
DI 10.1089/met.2021.0022
EA AUG 2021
PG 14
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA WV6IJ
UT WOS:000685557400001
PM 34402660
DA 2025-06-11
ER

PT J
AU Minár, M
   Dragasek, J
   Valkovic, P
AF Minar, Michal
   Dragasek, Jozef
   Valkovic, Peter
TI Psychiatric and somatic co-morbidities in patients with Parkinson's
   disease: A STROBE-compliant national multi-center, cross-sectional,
   observational study COSMOS in Slovakia
SO NEUROENDOCRINOLOGY LETTERS
LA English
DT Article
DE Parkinson's disease; prevalence; co-morbidity; psychiatric; somatic
ID QUALITY-OF-LIFE; SLEEP DISORDERS; COMORBIDITIES; POPULATION; PREVALENCE;
   FREQUENCY; IMPACT
AB OBJECTIVE: Co-morbidities in any disorder can complicate its diagnostic process, they require more complex clinical management and lead to worse health outcomes and increased healthcare costs. There are regional differences in the prevalence of specific co-morbidities in Parkinson's disease (PD), and data from middle Europe are lacking. The project COSMOS aimed to disclose the prevalence of co-morbidities among patients with PD in Slovakia.
   METHODS: In a national, multi-center, cross-sectional, observational study, neurologists gathered relevant demographical and clinical data aimed at all psychiatric and somatic co-morbidities.
   RESULTS: From overall 737 patients, 51.00 % had at least one psychiatric co-morbidity, the most prevalent were depressive episode/recurrent depressive disorder (26.05%), sleep disorders (23.20%), dementia (13.16%), and neurotic, stress-related, and somatoform disorders (11.53%). In addition, 92.9 % had at least one somatic co-morbidity, the most prevalent were hypertensive diseases (67.71%), ischemic heart diseases (42.74%), diseases of the musculoskeletal system, and connective tissue (39.21), and disorders of lipoprotein metabolism (33.24%). The number of psychiatric co-morbidities increased with PD progression; the prevalence of somatic comorbidities increased also with the age (p<0.001 in all cases).
   CONCLUSION: This study with a large cohort of PD patients confirmed a high prevalence of depression, dementia, sleep problems, and anxiety disorders, together with cardiovascular disorders, diseases of the musculoskeletal system, and metabolic syndrome. With PD progression, the number of both psychiatric and somatic co-morbidities is on the increase. If not treated properly, they lead to more complicated management. That's why it's essential to search for any co-morbidity to provide patients with early and adequate therapy to avoid further worsening of quality of life.
C1 [Minar, Michal; Valkovic, Peter] Comenius Univ, Univ Hosp Bratislava, Fac Med, Dept Neurol 2, Bratislava, Slovakia.
   [Dragasek, Jozef] Pavol Jozef Safarik Univ, Dept Psychiat 1, Kosice, Slovakia.
   [Valkovic, Peter] Slovak Acad Sci, Ctr Expt Med, Inst Normal & Pathol Physiol, Bratislava, Slovakia.
C3 Slovak Medical University Bratislava; Comenius University Bratislava;
   University of Pavol Jozef Safarik Kosice; Slovak Academy of Sciences;
   Institute of Normal & Pathological Physiology, SAS; Centre of
   Experimental Medicine, SAS
RP Minár, M (corresponding author), Comenius Univ, Univ Hosp Bratislava, Fac Med, Dept Neurol 2, Bratislava, Slovakia.
EM mmminar@gmail.com
RI Minár, Michal/AAE-9061-2022; Dragasek, Jozef/B-5070-2010
OI Dragasek, Jozef/0000-0003-2938-6675
FU Krka Slovakia Grant
FX This project was funded by Krka Slovakia Grant.
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NR 17
TC 3
Z9 3
U1 0
U2 4
PU MAGHIRA & MAAS PUBLICATIONS
PI MUNSBACH
PA MAGHIRA & MAAS S A R L, 6C, RUE GABRIEL LIPPMANN, L-5365 MUNSBACH,
   LUXEMBOURG
SN 0172-780X
EI 2354-4716
J9 NEUROENDOCRINOL LETT
JI Neuroendocrinol. Lett.
PY 2022
VL 43
IS 1
BP 39
EP 44
PG 6
WC Endocrinology & Metabolism; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology
GA 9M6TN
UT WOS:000942359700005
PM 35490424
DA 2025-06-11
ER

PT J
AU Pothinam, S
   Putpim, C
   Siriwoharn, T
   Jirarattanarangsri, W
AF Pothinam, Suwajee
   Putpim, Chaochetdhapada
   Siriwoharn, Thanyaporn
   Jirarattanarangsri, Wachira
TI Effects of Perilla Seed Oil on Blood Lipids, Oxidative Stress, and
   Inflammation in Hyperlipidemic Rats
SO FOODS
LA English
DT Article
DE inflammation; metabolic syndrome; omega-3 fatty acids; perilla seed oil
ID ALPHA-LINOLENIC ACID; CARDIOVASCULAR-DISEASE; OMEGA-3-FATTY-ACIDS;
   CHOLESTEROL; METABOLISM; RISK; MECHANISMS; HEALTH; HDL
AB A high-fat diet is a key factor contributing to hyperlipidemia. Perilla seed oil, a plant-based source of omega-3, has the potential to reduce this risk. However, its effects have not been fully established. This study aimed to evaluate the effects of perilla seed oil on blood lipid levels, oxidative stress, and inflammation in rats induced with hyperlipidemia through a high-fat diet. Male Wistar rats were administered perilla seed oil at a dosage of 0.67 g/kg body weight per day for 8 weeks. The results showed that perilla seed oil significantly reduced triglyceride levels by 38.00% and 41.88% and total cholesterol levels by 17.16% and 15.91% in the high-fat diet and normal diet groups, respectively (p < 0.05). However, perilla seed oil had no significant effect on HDL and LDL levels. Additionally, perilla seed oil supplementation significantly reduced malondialdehyde (MDA) levels, a biomarker of oxidative stress, by 68.18% in the high-fat diet group and 29.72% in the normal diet group. Regarding its anti-inflammatory effects, perilla seed oil reduced interleukin-6 (IL-6) levels by 15.21% and 64.27% in the high-fat diet and normal diet groups, respectively (p < 0.05). These findings suggest that perilla seed oil has the potential to reduce the risk of metabolic syndrome.
C1 [Pothinam, Suwajee; Siriwoharn, Thanyaporn; Jirarattanarangsri, Wachira] Chiang Mai Univ, Fac Agroind, Div Food Sci & Technol, Chiang Mai 50100, Thailand.
   [Putpim, Chaochetdhapada] Chiang Mai Univ, Lab Anim Ctr, Off Res Adm, Chiang Mai 50100, Thailand.
C3 Chiang Mai University; Chiang Mai University
RP Siriwoharn, T; Jirarattanarangsri, W (corresponding author), Chiang Mai Univ, Fac Agroind, Div Food Sci & Technol, Chiang Mai 50100, Thailand.
EM suwajeepo@gmail.com; chaochetdhapada.put@cmu.ac.th;
   thanyaporn.s@cmu.ac.th; wachira.j@cmu.ac.th
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NR 53
TC 0
Z9 0
U1 1
U2 1
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2304-8158
J9 FOODS
JI Foods
PD APR 17
PY 2025
VL 14
IS 8
AR 1380
DI 10.3390/foods14081380
PG 12
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA 1YD0D
UT WOS:001476413700001
PM 40282780
DA 2025-06-11
ER

PT J
AU Chan, SW
   Tomlinson, B
AF Chan, Sze Wa
   Tomlinson, Brian
TI Effects of Bilberry Supplementation on Metabolic and Cardiovascular
   Disease Risk
SO MOLECULES
LA English
DT Review
DE bilberry; antioxidant; anti-inflammatory; cardiovascular disease;
   hypoglycemic effect; type 2 diabetes
ID VACCINIUM-MYRTILLUS EXTRACT; OXIDATIVE STRESS; WEIGHT-LOSS; ANTIOXIDANT
   CAPACITY; HUMAN HEALTH; INFLAMMATORY CYTOKINES; DIABETES-MELLITUS;
   BLOOD-PRESSURE; SERUM GLUCOSE; VITAMIN-C
AB Metabolic syndrome is a cluster of interrelated conditions that is associated with an increased risk of cardiovascular disease (CVD) and type 2 diabetes mellitus (T2DM). Oxidative stress may impair normal physiological functions, leading to various illnesses. T2DM is considered to be associated with increased oxidative stress, inflammation, and dyslipidemia, which may play a significant role in the development of cardiovascular complications, cancer and vision loss through cataracts and retinopathy. While conventional therapies are a cornerstone for the management of the major risk factors of metabolic syndrome, increasing antioxidant defense by increasing intake of antioxidant-rich foods may improve long term prospects in CVD, obesity and T2DM. Bilberry (Vaccinium myrtillus L.) is one of the richest natural sources of anthocyanins which give berries their red/purple/blue coloration. Anthocyanins are powerful antioxidants and are reported to play an important role in the prevention of metabolic disease and CVD as well as cancer and other conditions. This review focuses on the potential effects of bilberry supplementation on metabolic and cardiovascular risk factors. Although there is evidence to support the use of bilberry supplementation as part of a healthy diet, the potential benefits from the use of bilberry supplementation in patients with T2DM or CVD needs to be clarified in large clinical trials.
C1 [Chan, Sze Wa] Caritas Inst Higher Educ, Sch Hlth Sci, Hong Kong 999077, Peoples R China.
   [Tomlinson, Brian] Macau Univ Sci & Technol, Fac Med, Macau 853, Peoples R China.
C3 Saint Francis University Hong Kong; Macau University of Science &
   Technology
RP Chan, SW (corresponding author), Caritas Inst Higher Educ, Sch Hlth Sci, Hong Kong 999077, Peoples R China.; Tomlinson, B (corresponding author), Macau Univ Sci & Technol, Fac Med, Macau 853, Peoples R China.
EM swchan@cihe.edu.hk; btomlinson@must.edu.mo
RI Tomlinson, Brian/AAD-9404-2019
OI Chan, Sze Wa/0000-0002-2979-3855; Tomlinson, Brian/0000-0001-6717-5444
FU Caritas Institute of Higher Education [IRG200101]
FX This work is funded by an Internal Research Grant from the Caritas
   Institute of Higher Education, grant number IRG200101.
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NR 100
TC 28
Z9 28
U1 2
U2 16
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1420-3049
J9 MOLECULES
JI Molecules
PD APR
PY 2020
VL 25
IS 7
AR 1653
DI 10.3390/molecules25071653
PG 15
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA LL8VZ
UT WOS:000531833400178
PM 32260262
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Nakyam, T
   Wattanathorn, J
   Thukham-mee, W
AF Nakyam, Thuntiva
   Wattanathorn, Jintanaporn
   Thukham-mee, Wipawee
TI Neuroprotective Effect of Polyherbal Recipe Containing Ginger, Chinese
   Date, and Wood Ear Mushroom against Ischemic Stroke with Metabolic
   Syndrome Condition via Epigenetic Modification of Inflammation and
   Oxidative Stress
SO BIOMED RESEARCH INTERNATIONAL
LA English
DT Article
AB Currently, the prevalence of stroke with metabolic syndrome (MetS) is increasing and the current therapeutic efficiency is still limited. Therefore, the applications of herbal recipes have gained much attention. The polyherbal recipe containing ginger, Chinese date, and wood ear mushroom is reputed for atherosclerosis and stroke prevention. It has been long-term consumed without scientific support. Therefore, this study was carried out to determine the neuroprotective effect and its mechanisms in animal model of ischemic stroke with MetS. Male Wistar rats weighing 180-220 g were exposed to a 16-week high-fat high-carbohydrate feeding. The rats with the MetS characteristic were exposed to a temporary occlusion of the right middle cerebral artery (MCAO) for 90 minutes. They were orally fed with the polyherbal recipe (GCJ) at the doses of 100, 200, and 300 mg/kg BW for 21 days and assessed the neurological deficit, ion volume, cortical neuron density in the cerebral cortex, oxidative stress status, inflammation, and expressions of histone deacetylase 3 (HDAC3) and DNA methyltransferase 1 (DNMT1). The results showed that GCJ significantly improved all mentioned parameters. Therefore, GCJ is the potential neuroprotectant against ischemic stroke with MetS. The underlying mechanisms may involve the reduction of oxidative stress, inflammation, and the modification of epigenetic mechanism via the reduction of HDAC3 and DNMT1. However, further clinical investigation is essential to confirm this positive modulation effect.
C1 [Nakyam, Thuntiva] Khon Kaen Univ, Dept Physiol, Khon Kaen 40002, Thailand.
   [Nakyam, Thuntiva] Khon Kaen Univ, Grad Sch, Neurosci Program, Fac Med, Khon Kaen 40002, Thailand.
   [Wattanathorn, Jintanaporn; Thukham-mee, Wipawee] Khon Kaen Univ, Res Inst Human High Performance & Hlth Prom, Khon Kaen 40002, Thailand.
   [Wattanathorn, Jintanaporn; Thukham-mee, Wipawee] Khon Kaen Univ, Fac Med, Dept Physiol, Khon Kaen 40002, Thailand.
C3 Khon Kaen University; Khon Kaen University; Khon Kaen University; Khon
   Kaen University
RP Wattanathorn, J (corresponding author), Khon Kaen Univ, Res Inst Human High Performance & Hlth Prom, Khon Kaen 40002, Thailand.; Wattanathorn, J (corresponding author), Khon Kaen Univ, Fac Med, Dept Physiol, Khon Kaen 40002, Thailand.
EM jinwat05@gmail.com
OI Thukhammee, Wipawee/0000-0001-6923-396X; Wattanathorn,
   Jintanaporn/0000-0002-7383-2348; Nakyam, Thuntiva/0000-0002-3835-6198
FU Thailand Science Research and Innovation (TSRI) through the Research and
   Researchers for Industries (RRI) project [PHD59I0036]; Agricultural
   Research Development Agency (ARDA); Integrative Complementary
   Alternative Medicine Research and Development Center in the Research
   Institute for Human High Performance and Health Promotion, Khon Kaen
   University, Khon Kaen, Thailand
FX The authors would like to express sincere gratitude to the Thailand
   Science Research and Innovation (TSRI) through the Research and
   Researchers for Industries (RRI) project (research no. PHD59I0036), the
   Agricultural Research Development Agency (ARDA), and the Integrative
   Complementary Alternative Medicine Research and Development Center in
   the Research Institute for Human High Performance and Health Promotion,
   Khon Kaen University, Khon Kaen, Thailand, for their supports.
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NR 47
TC 2
Z9 2
U1 1
U2 2
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2314-6133
EI 2314-6141
J9 BIOMED RES INT
JI Biomed Res. Int.
PD AUG 17
PY 2022
VL 2022
AR 8940303
DI 10.1155/2022/8940303
PG 14
WC Biotechnology & Applied Microbiology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Research & Experimental Medicine
GA VN4VZ
UT WOS:001153394200001
PM 39281061
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Nunes-Souza, V
   César-Gomes, CJ
   Da Fonseca, LJS
   Guedes, GD
   Smaniotto, S
   Rabelo, LA
AF Nunes-Souza, Valeria
   Cesar-Gomes, Cheila Juliana
   Sa Da Fonseca, Lucas Jose
   Guedes, Glaucevane Da Silva
   Smaniotto, Salete
   Rabelo, Luiza Antas
TI Aging Increases Susceptibility to High Fat Diet-Induced Metabolic
   Syndrome in C57BL/6 Mice: Improvement in Glycemic and Lipid Profile
   after Antioxidant Therapy
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Article
ID INCREASED OXIDATIVE STRESS; AIN-93 PURIFIED DIETS; INSULIN-RESISTANCE;
   ENDOTHELIAL DYSFUNCTION; NAD(P)H OXIDASE; HEPATIC STEATOSIS;
   LIVER-DISEASE; B DEGRADATION; GLUCOSE; RODENTS
AB Nonalcoholic fatty liver disease (NAFLD) has been considered a novel component of the metabolic syndrome (MetS), with the oxidative stress participating in its progression. This study aimed to evaluate the metabolic profile in young and old mice with MetS, and the effects of apocynin and tempol on glycemic and lipid parameters. Young and old C57BL/6 mice with high fat diet- (HFD-) induced MetS received apocynin and tempol 50 mg.kg(-1)/day in their drinking water for 10 weeks. After HFD, the young group showed elevated fasting glucose, worsened lipid profile in plasma, steatosis, and hepatic lipid peroxidation. Nevertheless, the old group presented significant increase in fasting insulin levels, insulin resistance, plasma and hepatic lipid peroxidation, and pronounced steatosis. The hepatic superoxide dismutase and catalase activity did not differ between the groups. Tempol and apocynin seemed to prevent hepatic lipid deposition in both groups. Furthermore, apocynin improved glucose tolerance and insulin sensitivity in old mice. In summary, old mice are more susceptible to HFD-induced metabolic changes than their young counterparts. Also, the antioxidant therapy improved insulin sensitivity and glucose tolerance, and in addition, apocynin seemed to prevent the HFD-induced hepatic fat deposition, suggesting an important role of oxidative stress in the induction of NAFLD.
C1 [Nunes-Souza, Valeria; Cesar-Gomes, Cheila Juliana; Sa Da Fonseca, Lucas Jose; Guedes, Glaucevane Da Silva; Rabelo, Luiza Antas] Univ Fed Alagoas UFAL, LRC, ICBS, Nucleo Sindrome Metab, Ave Lourival Melo Mota S-N,Cidade Univ, BR-57072900 Maceio, AL, Brazil.
   [Nunes-Souza, Valeria; Cesar-Gomes, Cheila Juliana; Sa Da Fonseca, Lucas Jose; Guedes, Glaucevane Da Silva; Rabelo, Luiza Antas] Natl Inst Sci & Technol Nanobiopharmaceut N BIOFA, Ave Antonio Carlos S-N, BR-31270901 Belo Horizonte, MG, Brazil.
   [Nunes-Souza, Valeria] Univ Fed Pernambuco UFPE, CCB, Dept Fisiol & Farmacol, Ave Prof Moraes Rego 1235,Cidade Univ, BR-50670901 Recife, PE, Brazil.
   [Guedes, Glaucevane Da Silva] Univ Fed Alagoas UFAL, Fac Nutr FANUT, Ave Lourival Melo Mota S-N,Cidade Univ, BR-57072900 Maceio, AL, Brazil.
   [Smaniotto, Salete] Univ Fed Alagoas UFAL, ICBS, Lab Biol Celular, Ave Lourival Melo Mota S-N,Cidade Univ, BR-57072900 Maceio, AL, Brazil.
   [Rabelo, Luiza Antas] Max Delbruck Ctr Mol Med, Robert Rossle Str 10, D-13125 Berlin, Germany.
C3 Universidade Federal de Pernambuco; Helmholtz Association; Max Delbruck
   Center for Molecular Medicine
RP Rabelo, LA (corresponding author), Univ Fed Alagoas UFAL, LRC, ICBS, Nucleo Sindrome Metab, Ave Lourival Melo Mota S-N,Cidade Univ, BR-57072900 Maceio, AL, Brazil.; Rabelo, LA (corresponding author), Natl Inst Sci & Technol Nanobiopharmaceut N BIOFA, Ave Antonio Carlos S-N, BR-31270901 Belo Horizonte, MG, Brazil.; Rabelo, LA (corresponding author), Max Delbruck Ctr Mol Med, Robert Rossle Str 10, D-13125 Berlin, Germany.
EM luizaa.rabelo@gmail.com
RI Smaniotto, Salete/AAT-4056-2020; Rabêlo, Luiza/S-4050-2019; Smaniotto,
   Salete/T-3796-2017
OI Smaniotto, Salete/0000-0003-1527-5894
FU Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES;
   PROCAD-NF) [2450/2008]; Conselho Nacional de Desenvolvimento Cientifico
   e Tecnologico (CNPq) [483049/2009-3]; CNPq; FAPEAL; CAPES
FX The authors wish to thank Maria de Fatima Maia Sarmento and Delma Paes
   de Souza for their technical assistance during histology preparation and
   Iris Apostel-Krause for their assistance with the English revision of
   the paper. The authors wish to thank Coordenacao de Aperfeicoamento de
   Pessoal de Nivel Superior (CAPES; PROCAD-NF 2450/2008) and Conselho
   Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq;
   483049/2009-3), for the financial support, and Professor Dr. Michael
   Bader and Dr. Natalia Alenina (Max Delbruck Center for Molecular
   Medicine, Berlin, Germany) for the donation of some reagents used during
   the assessment of the oxidative status. Valeria Nunes-Souza, Cheila
   Juliana Cesar-Gomes, and Lucas Jose Sa Da Fonseca received a Master's
   Scholarship from CNPq, FAPEAL, and CAPES, respectively.
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NR 47
TC 30
Z9 32
U1 0
U2 9
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PY 2016
VL 2016
AR 1987960
DI 10.1155/2016/1987960
PG 17
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA DK4EG
UT WOS:000374869300001
PM 27057272
OA Green Submitted, Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Zhuo, Q
   Yang, W
   Chen, JY
   Wang, Y
AF Zhuo, Qi
   Yang, Wei
   Chen, Jiying
   Wang, Yan
TI Metabolic syndrome meets osteoarthritis
SO NATURE REVIEWS RHEUMATOLOGY
LA English
DT Review
ID GLYCATION END-PRODUCTS; NITRIC-OXIDE SYNTHASE; DEPENDENT
   DIABETES-MELLITUS; 3RD NATIONAL-HEALTH; BODY-MASS INDEX; FACTOR-KAPPA-B;
   KNEE OSTEOARTHRITIS; OXIDATIVE STRESS; CARDIOVASCULAR-DISEASE;
   RADIOGRAPHIC OSTEOARTHRITIS
AB Metabolic osteoarthritis (OA) has now been characterized as a subtype of OA, and links have been discovered between this phenotype and metabolic syndrome (MetS)-both with individual MetS components and with MetS as a whole. Hypertension associates with OA through subchondral ischaemia, which can compromise nutrient exchange into articular cartilage and trigger bone remodelling. Ectopic lipid deposition in chondrocytes induced by dyslipidemia might initiate OA development, exacerbated by deregulated cellular lipid metabolism in joint tissues. Hyperglycaemia and OA interact at both local and systemic levels; local effects of oxidative stress and advanced glycation end-products are implicated in cartilage damage, whereas low-grade systemic inflammation results from glucose accumulation and contributes to a toxic internal environment that can exacerbate OA. Obesity-related metabolic factors, particularly altered levels of adipokines, contribute to OA development by inducing the expression of proinflammatory factors as well as degradative enzymes, leading to the inhibition of cartilage matrix synthesis and stimulation of subchondral bone remodelling. In this Review, we summarize the shared mechanisms of inflammation, oxidative stress, common metabolites and endothelial dysfunction that characterize the aetiologies of OA and MetS, and nominate metabolic OA as the fifth component of MetS. We also describe therapeutic opportunities that might arise from uniting these concepts. Zhuo, Q. et al. Nat. Rev. Rheumatol. 8, 729-737 (2012); published online 21 August 2012; doi:10.1038/nrrheum.2012.135
C1 [Zhuo, Qi; Chen, Jiying; Wang, Yan] Chinese Peoples Liberat Army Gen Hosp, Dept Orthopaed, Beijing 100853, Peoples R China.
   [Yang, Wei] Chinese Peoples Liberat Army Gen Hosp, Dept Endocrinol, Beijing 100853, Peoples R China.
C3 Chinese People's Liberation Army General Hospital; Chinese People's
   Liberation Army General Hospital
RP Wang, Y (corresponding author), Chinese Peoples Liberat Army Gen Hosp, Dept Orthopaed, Fuxing Rd 28, Beijing 100853, Peoples R China.
EM yannwang301@yahoo.com
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NR 149
TC 433
Z9 477
U1 1
U2 118
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 1759-4790
EI 1759-4804
J9 NAT REV RHEUMATOL
JI Nat. Rev. Rheumatol.
PD DEC
PY 2012
VL 8
IS 12
BP 729
EP 737
DI 10.1038/nrrheum.2012.135
PG 9
WC Rheumatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Rheumatology
GA 051LO
UT WOS:000312128600007
PM 22907293
DA 2025-06-11
ER

PT J
AU Tam, E
   Sweeney, G
AF Tam, Eddie
   Sweeney, Gary
TI MitoNEET Provides Cardioprotection via Reducing Oxidative Damage and
   Conserving Mitochondrial Function
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE mitoNEET; mitochondria; iron metabolism; oxidative stress;
   cardiometabolic disease
ID MEMBRANE PROTEIN; GLOBAL BURDEN; DISEASE; STRESS; HEART; IDENTIFICATION;
   FERROPTOSIS; DYSFUNCTION; TT01001
AB Cardiometabolic diseases exert a significant health impact, leading to a considerable economic burden globally. The metabolic syndrome, characterized by a well-defined cluster of clinical parameters, is closely linked to an elevated risk of cardiovascular disease. Current treatment strategies often focus on addressing individual aspects of metabolic syndrome. We propose that exploring novel therapeutic approaches that simultaneously target multiple facets may prove more effective in alleviating the burden of cardiometabolic disease. There is a growing body of evidence suggesting that mitochondria can serve as a pivotal target for the development of therapeutics aimed at resolving both metabolic and vascular dysfunction. MitoNEET was identified as a binding target for the thiazolidinedione (TZD) class of antidiabetic drugs and is now recognized for its role in regulating various crucial cellular processes. Indeed, mitoNEET has demonstrated promising potential as a therapeutic target in various chronic diseases, encompassing cardiovascular and metabolic diseases. In this review, we present a thorough overview of the molecular mechanisms of mitoNEET, with an emphasis on their implications for cardiometabolic diseases in more recent years. Furthermore, we explore the potential impact of these findings on the development of novel therapeutic strategies and discuss potential directions for future research.
C1 [Tam, Eddie; Sweeney, Gary] York Univ, Dept Biol, Toronto, ON M3J 1P3, Canada.
C3 York University - Canada
RP Sweeney, G (corresponding author), York Univ, Dept Biol, Toronto, ON M3J 1P3, Canada.
EM gsweeney@yorku.ca
OI Tam, Eddie/0009-0002-8480-7145
FU National Science and Engineering Research Council
FX No Statement Available
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NR 78
TC 6
Z9 6
U1 0
U2 5
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD JAN
PY 2024
VL 25
IS 1
AR 480
DI 10.3390/ijms25010480
PG 15
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA ER3D8
UT WOS:001140602500001
PM 38203651
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU de Franca, E
   dos Santos, RVT
   Baptista, LC
   Da Silva, MAR
   Fukushima, AR
   Hirota, VB
   Martins, RA
   Caperuto, EC
AF de Franca, Elias
   dos Santos, Ronaldo V. T.
   Baptista, Liliana C.
   Da Silva, Marco A. R.
   Fukushima, Andre R.
   Hirota, Vinicius B.
   Martins, Raul A.
   Caperuto, Erico C.
TI Potential Role of Chronic Physical Exercise as a Treatment in the
   Development of Vitiligo
SO FRONTIERS IN PHYSIOLOGY
LA English
DT Article
DE vitiligo; autoimmune disease; physical training; immune system;
   oxidative stress; metabolic syndrome
ID BLOOD MONONUCLEAR-CELLS; CD8(+) T-CELLS; OXIDATIVE STRESS; METABOLIC
   SYNDROME; MELANOCYTE DEGENERATION; AUTOIMMUNE-DISEASES;
   CALCIUM-TRANSPORT; GENETIC-VARIANTS; IMMUNE-RESPONSE; IFN-GAMMA
AB Vitiligo is an autoimmune disease characterized by progressive skin depigmentation and the appearance of white patches throughout the body caused by significant apoptosis of epidermal melanocytes. Despite not causing any physical pain, vitiligo can originate several psychosocial disorders, drastically reducing patients' quality of life. Emerging evidence has shown that vitiligo is associated with several genetic polymorphisms related to auto-reactivity from the immune system to melanocytes. Melanocytes from vitiligo patients suffer from excess reactive oxygen species (ROS) produced by defective mitochondria besides a poor endogenous antioxidant system (EAS). This redox imbalance results in dramatic melanocyte oxidative stress (OS), causing significant damage in proteins, lipid membranes, and DNA. The damaged melanocytes secret damage-associated molecular pattern (DAMPs), inducing and increasing inflammatory gene expression response that ultimately leads to melanocytes apoptosis. Vitiligo severity has been also associated with increasing the prevalence and incidence of metabolic syndrome (MetS) or associated disorders such as insulin resistance and hypercholesterolemia. Thus, suggesting that in genetically predisposed individuals, the environmental context that triggers MetS (i.e., sedentary lifestyle) may also be an important trigger for the development and severity of vitiligo disease. This paper will discuss the relationship between the immune system and epidermal melanocytes and their interplay with the redox system. Based on state-of-the-art evidence from the vitiligo research, physical exercise (PE) immunology, and redox system literature, we will also propose chronic PE as a potential therapeutic strategy to treat and prevent vitiligo disease progression. We will present evidence that chronic PE can change the balance of inflammatory to an anti-inflammatory state, improve both EAS and the mitochondrial structure and function (resulting in the decrease of OS). Finally, we will highlight clinically relevant markers that can be analyzed in a new research avenue to test the potential applicability of chronic PE in vitiligo disease.
C1 [de Franca, Elias; Caperuto, Erico C.] Sao Judas Univ, Human Movement Lab, Sao Paulo, Brazil.
   [de Franca, Elias; dos Santos, Ronaldo V. T.] Univ Fed Sao Paulo, Dept Biociencias, Sao Paulo, Brazil.
   [Baptista, Liliana C.] Univ Porto, Fac Sport, Res Ctr Phys Act, Hlth & Leisure, Porto, Portugal.
   [Baptista, Liliana C.] Univ Alabama Birmingham, Ctr Exercise Med, Birmingham, AL USA.
   [Baptista, Liliana C.] Univ Alabama Birmingham, Microbiome & Aging Lab, Targeted Exercise, Birmingham, AL USA.
   [Da Silva, Marco A. R.] Univ Coimbra, Fac Sport Sci & Phys Educ, Coimbra, Portugal.
   [Da Silva, Marco A. R.] Univ Amazonia, Dept Phys Educ, Belem, Brazil.
   [Fukushima, Andre R.; Hirota, Vinicius B.] Ctr Univ Amer, FAM, Sao Paulo, Brazil.
   [Fukushima, Andre R.] Fac Ciencias Saude, IGESP, FASIG, Sao Paulo, Brazil.
C3 Universidade Federal de Sao Paulo (UNIFESP); Universidade do Porto;
   University of Alabama System; University of Alabama Birmingham;
   University of Alabama System; University of Alabama Birmingham;
   Universidade de Coimbra; Universidade da Amazonia (UNAMA)
RP de Franca, E (corresponding author), Sao Judas Univ, Human Movement Lab, Sao Paulo, Brazil.; de Franca, E (corresponding author), Univ Fed Sao Paulo, Dept Biociencias, Sao Paulo, Brazil.
EM elias.franca@unifesp.br
RI Thomatieli-Santos, Ronaldo/C-8209-2012; de França, Elias/J-9867-2014; da
   Silva, Marco/AGM-6135-2022; Caperuto, Erico/I-3605-2014; Baptista,
   Liliana/AFM-0544-2022; barroso hirota, vinicius/D-1291-2014; Fukushima,
   Andre/A-7610-2017
OI barroso hirota, vinicius/0000-0002-0166-3338; Baptista,
   Liliana/0000-0002-3534-1839; Fukushima, Andre/0000-0001-6026-3054;
   Martins, Raul A./0000-0003-1194-4560
FU FAPESP-Fundacao de Amparo a Pesquisa do Estado de Sao Paulo
   [2021/03601-01]; CAPES-Coordenacao de Aperfeicoamento de Pessoal de
   Nivel Superior
FX EF is thankful to FAPESP-Fundacao de Amparo a Pesquisa do Estado de Sao
   Paulo (grant no. 2021/03601-01) and CAPES-Coordenacao de Aperfeicoamento
   de Pessoal de Nivel Superior to providing the Ph.D. and postdoctoral
   scholarships, respectively, which made possible to conduct such study
   and many other experiments.
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NR 126
TC 3
Z9 3
U1 1
U2 12
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1664-042X
J9 FRONT PHYSIOL
JI Front. Physiol.
PD MAR 10
PY 2022
VL 13
AR 843784
DI 10.3389/fphys.2022.843784
PG 18
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA 0G9FH
UT WOS:000778343200001
PM 35360245
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Fang, YY
   Huang, CY
   Hsu, MC
AF Fang, Yun-Ya
   Huang, Chien-Yuan
   Hsu, Mei-Chi
TI Effectiveness of a physical activity program on weight, physical
   fitness, occupational stress, job satisfaction and quality of life of
   overweight employees in high-tech industries: a randomized controlled
   study
SO INTERNATIONAL JOURNAL OF OCCUPATIONAL SAFETY AND ERGONOMICS
LA English
DT Article
DE physical activity; overweight; occupational stress; job satisfaction;
   quality of life; nursing practice
ID CARDIORESPIRATORY FITNESS; EXERCISE INTERVENTION; CARDIOVASCULAR RISK;
   METABOLIC SYNDROME; HEALTH; DISEASE; HEART; WORK
AB Introduction. This study aimed to examine the effectiveness of a physical activity (PA) program on weight control, physical fitness, occupational stress, job satisfaction and quality of life of overweight and sedentary employees in high-tech industries. Methods. Participants in the intervention group (n = 37) were instructed to carry out a PA program at moderate intensity for 60 min/session, 3 sessions/week for 12 weeks. Those in the control group (n = 38) received no PA program and were asked to continue their routine lifestyle. Evaluations were performed at baseline and at the end of the intervention. Results of structured questionnaires and blood biochemistry tests and evaluations of physical fitness were analyzed. Results. The PA program effectively reduced the number of risk factors for metabolic syndrome and body fat percentage, and improved physical fitness such as flexibility, muscular strength and endurance and cardiorespiratory endurance. The intervention also significantly decreased levels of serum triglyceride, total cholesterol and low-density lipoprotein cholesterol. Significant positive effects on work control, interpersonal relationships at work, global job satisfaction and quality of life were also demonstrated. Conclusion. This study showed that a PA program can be helpful in improving physical, physiological and psychological outcomes for overweight and sedentary employees in high-tech industries.
C1 [Fang, Yun-Ya; Huang, Chien-Yuan] Chi Mei Med Ctr, Tainan Sci Pk Clin, Tainan, Taiwan.
   [Hsu, Mei-Chi] I Shou Univ, Dept Nursing, Kaohsiung, Taiwan.
C3 Chi Mei Hospital; I Shou University
RP Hsu, MC (corresponding author), I Shou Univ, Dept Nursing, Kaohsiung, Taiwan.
EM hsu88@isu.edu.tw
OI Yunya, Fang/0000-0003-1417-8347
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NR 28
TC 49
Z9 52
U1 2
U2 88
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1080-3548
EI 2376-9130
J9 INT J OCCUP SAF ERGO
JI Int. J. Occup. Saf. Ergon.
PD OCT 2
PY 2019
VL 25
IS 4
BP 621
EP 629
DI 10.1080/10803548.2018.1438839
PG 9
WC Ergonomics; Public, Environmental & Occupational Health
WE Social Science Citation Index (SSCI)
SC Engineering; Public, Environmental & Occupational Health
GA IM4JS
UT WOS:000477961300015
PM 29465293
DA 2025-06-11
ER

PT J
AU Sladowska-Kozlowska, J
   Litwin, M
   Niemirska, A
   Pludowski, P
   Wierzbicka, A
   Skorupa, E
   Wawer, ZT
   Janas, R
AF Sladowska-Kozlowska, Joanna
   Litwin, Mieczyslaw
   Niemirska, Anna
   Pludowski, Pawel
   Wierzbicka, Aldona
   Skorupa, Ewa
   Wawer, Zbigniew T.
   Janas, Roman
TI Oxidative stress in hypertensive children before and after 1 year of
   antihypertensive therapy
SO PEDIATRIC NEPHROLOGY
LA English
DT Article; Proceedings Paper
CT Meeting of the European-Society-of-Hypertension
CY 2011
CL Milan, ITALY
SP European Soc Hypertens
DE Primary hypertension; Oxidative stress; Metabolic syndrome; Insulin
   resistance; Target organ damage; Antihypertensive therapy; Children
ID INTIMA-MEDIA THICKNESS; NITRIC-OXIDE SYNTHASE; AMBULATORY
   BLOOD-PRESSURE; OXYGEN SPECIES FORMATION; LEFT-VENTRICULAR MASS;
   INSULIN-RESISTANCE; RECOMMENDATIONS; ADOLESCENTS; OVERWEIGHT; INHIBITORS
AB The relation between primary hypertension (PH), target organ damage (TOD) and oxidative stress (SOX) is not known.
   We assessed SOX in 86 children with PH before and after 12 months of standard non-pharmacological and pharmacological therapy based on renin-angiotensin system blockade.
   Patients with left ventricular hypertrophy (LVH) and with carotid intima-media thickness (cIMT) > 2SDS had higher thiobarbituric acid reactive substances (TBARS) concentrations in comparison to patients without LVH or with normal cIMT. Patients with metabolic syndrome (MS) had lower activity of gluthatione peroxidase, higher asymmetric dimethyloarginine (ADMA) and oxidized LDL cholesterol (oxyLDL) in comparison to patients without MS. TBARS correlated with left ventricular concentric hypertrophy, cIMT, albuminuria and SBP/24 h. ADMA and oxyLDL correlated with CRP and TG/HDL ratio. After 1 year of antihypertensive treatment blood pressure, TOD and prevalence of MS decreased. TBARS decreased and glutathione concentrations increased. The decrease of TBARS concentration correlated with the decrease of body mass index (BMI). Decrease of oxyLDL and ADMA correlated with increased insulin sensitivity, however markers of SOX did not correlate with BP decrease.
   SOX in children with PH correlates with TOD, metabolic abnormalities, changes in fat amount and improvement of insulin sensitivity, but not with BP decrease.
C1 [Litwin, Mieczyslaw] Childrens Mem Hlth Inst, Dept Res, Warsaw, Poland.
   [Sladowska-Kozlowska, Joanna; Litwin, Mieczyslaw; Niemirska, Anna] Childrens Mem Hlth Inst, Dept Nephrol & Arterial Hypertens, Warsaw, Poland.
   [Pludowski, Pawel; Wierzbicka, Aldona; Skorupa, Ewa; Wawer, Zbigniew T.] Childrens Mem Hlth Inst, Dept Biochem & Expt Med, Warsaw, Poland.
   [Janas, Roman] Childrens Mem Hlth Inst, Dept Radioimmunol, Warsaw, Poland.
C3 Children's Memorial Health Institute; Children's Memorial Health
   Institute; Children's Memorial Health Institute; Children's Memorial
   Health Institute
RP Litwin, M (corresponding author), Childrens Mem Hlth Inst, Dept Res, Warsaw, Poland.
EM m.litwin@czd.pl
RI Pludowski, Pawel/P-2154-2018; Litwin, Mieczyslaw/L-4648-2017; Niemirska,
   Anna/W-2780-2018
OI Pludowski, Pawel/0000-0001-8475-7112; Janas, Roman/0000-0003-2853-9676;
   Litwin, Mieczyslaw/0000-0002-5241-2483; Niemirska,
   Anna/0000-0003-4546-5541; Wawer, Zbigniew/0000-0002-8866-4578;
   Wierzbicka-Rucinska, Aldona/0000-0002-9578-8894
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NR 44
TC 26
Z9 26
U1 0
U2 14
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0931-041X
EI 1432-198X
J9 PEDIATR NEPHROL
JI Pediatr. Nephrol.
PD OCT
PY 2012
VL 27
IS 10
BP 1943
EP 1951
DI 10.1007/s00467-012-2193-x
PG 9
WC Pediatrics; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Pediatrics; Urology & Nephrology
GA 992EL
UT WOS:000307758300016
PM 22660895
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Pedrosa, MA
   Labandeira, CM
   Lago-Baameiro, N
   Valenzuela, R
   Pardo, M
   Labandeira-Garcia, JL
   Rodriguez-Perez, AI
AF Pedrosa, Maria A.
   Labandeira, Carmen M.
   Lago-Baameiro, Nerea
   Valenzuela, Rita
   Pardo, Maria
   Labandeira-Garcia, Jose Luis
   Rodriguez-Perez, Ana I.
TI Extracellular Vesicles and Their Renin-Angiotensin Cargo as a Link
   between Metabolic Syndrome and Parkinson's Disease
SO ANTIOXIDANTS
LA English
DT Article
DE adipocytes; angiotensin receptor blockers; exosomes; NADPH-oxidase;
   neurodegeneration; neuroinflammation; obesity; oxidative stress
ID EXOSOME-MEDIATED TRANSFER; ADIPOSE-TISSUE; NADPH-OXIDASE; SYSTEM;
   OBESITY; MECHANISM; INFLAMMATION; ADIPOCYTES; BIOLOGY; KINASE
AB Several studies showed an association between metabolic syndrome (MetS) and Parkinson's disease (PD). The linking mechanisms remain unclear. MetS promotes low-grade peripheral oxidative stress and inflammation and dysregulation of the adipose renin-angiotensin system (RAS). Interestingly, brain RAS dysregulation is involved in the progression of dopaminergic degeneration and PD. Circulating extracellular vesicles (EVs) from MetS fat tissue can cross the brain-blood barrier and may act as linking signals. We isolated and characterized EVs from MetS and control rats and analyzed their mRNA and protein cargo using RT-PCR and the ExoView R200 platform, respectively. Furthermore, cultures of the N27 dopaminergic cell line and the C6 astrocytic cell line were treated with EVs from MetS rats. EVs were highly increased in MetS rat serum, which was inhibited by treatment of the rats with the angiotensin type-1-receptor blocker candesartan. Furthermore, EVs from MetS rats showed increased pro-oxidative/pro-inflammatory and decreased anti-oxidative/anti-inflammatory RAS components, which were inhibited in candesartan-treated MetS rats. In cultures, EVs from MetS rats increased N27 cell death and modulated C6 cell function, upregulating markers of neuroinflammation and oxidative stress, which were inhibited by the pre-treatment of cultures with candesartan. The results from rat models suggest EVs and their RAS cargo as a mechanism linking Mets and PD.
C1 [Pedrosa, Maria A.; Valenzuela, Rita; Labandeira-Garcia, Jose Luis; Rodriguez-Perez, Ana I.] Univ Santiago de Compostela, Res Ctr Mol Med & Chron Dis CIMUS, Cellular & Mol Neurobiol Parkinsons Dis, Inst Invest Sanitaria Santiago de Compostela IDIS, Santiago De Compostela 15782, Spain.
   [Pedrosa, Maria A.; Valenzuela, Rita; Labandeira-Garcia, Jose Luis; Rodriguez-Perez, Ana I.] Networking Res Ctr Neurodegenerat Dis CIBERNED, Madrid 28029, Spain.
   [Labandeira, Carmen M.] Univ Hosp Ourense, Neurol Serv, Orense 32005, Spain.
   [Lago-Baameiro, Nerea; Pardo, Maria] Complexo Hosp Univ Santiago de Compostela, Grp Obesid, Area Endocrinol, Inst Invest Sanitaria Santiago de Compostela IDIS, Santiago De Compostela 15706, Spain.
   [Pardo, Maria] Inst Salud Carlos III, CIBER Fisiopatol Obes & Nutr, Madrid 28029, Spain.
C3 Universidade de Santiago de Compostela; CIBERNED; Complexo Hospitalario
   Universitario de Ourense, Verin e O Barco de Valdeorras; Complexo
   Hospitalario Universitario de Santiago de Compostela; CIBER - Centro de
   Investigacion Biomedica en Red; CIBEROBN; Instituto de Salud Carlos III
RP Labandeira-Garcia, JL; Rodriguez-Perez, AI (corresponding author), Univ Santiago de Compostela, Res Ctr Mol Med & Chron Dis CIMUS, Cellular & Mol Neurobiol Parkinsons Dis, Inst Invest Sanitaria Santiago de Compostela IDIS, Santiago De Compostela 15782, Spain.; Labandeira-Garcia, JL; Rodriguez-Perez, AI (corresponding author), Networking Res Ctr Neurodegenerat Dis CIBERNED, Madrid 28029, Spain.
EM mary.pedrosa@usc.es; carmen.maria.labandeira.guerra@sergas.es;
   nerealagobaameiro@gmail.com; rita.valenzuela@usc.es;
   maria.pardo.perez@sergas.es; joseluis.labandeira@usc.es;
   anai.rodriguez@usc.es
RI García, José/AAM-3097-2021; Pedrosa, Maria A/ABA-2393-2021; Perez,
   Ana/AAM-1198-2021; Pardo, Maria/C-5124-2012
OI Valenzuela Liminana, Rita/0000-0001-8181-2841; Lago Baameiro,
   Nerea/0000-0003-1257-4856; Novoa Perez, Maria Iria/0009-0002-6073-9520;
   Pardo, Maria/0000-0002-9967-1650; Labandeira-Garcia, Jose
   Luis/0000-0002-8243-9791; Rodriguez Perez, Ana
   Isabel/0000-0003-1354-8799; Gianzo Quintela,
   Cristina/0009-0001-0012-0964; Labandeira Guerra, Carmen
   M./0000-0002-6274-5871; Aldrey Garcia, Maria Pilar/0009-0004-2253-1432;
   Pedrosa/0000-0001-9553-8513
FU Spanish Ministry of Science and Innovation
FX We thank Pilar Aldrey, Iria Novoa, and Cristina Gianzo for their
   technical assistance.
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NR 85
TC 7
Z9 8
U1 1
U2 5
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD DEC
PY 2023
VL 12
IS 12
AR 2045
DI 10.3390/antiox12122045
PG 23
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA DF4J7
UT WOS:001130599000001
PM 38136165
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Dallio, M
   Diano, N
   Masarone, M
   Gravina, AG
   Patanè, V
   Romeo, M
   Di Sarno, R
   Errico, S
   Nicolucci, C
   Abenavoli, L
   Scarpellini, E
   Boccuto, L
   Persico, M
   Loguercio, C
   Federico, A
AF Dallio, Marcello
   Diano, Nadia
   Masarone, Mario
   Gravina, Antonietta Gerarda
   Patane, Vittorio
   Romeo, Mario
   Di Sarno, Rosa
   Errico, Sonia
   Nicolucci, Carla
   Abenavoli, Ludovico
   Scarpellini, Emidio
   Boccuto, Luigi
   Persico, Marcello
   Loguercio, Carmelina
   Federico, Alessandro
TI Chemical Effect of Bisphenol A on Non-Alcoholic Fatty Liver Disease
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Review
DE bisphenol A; endocrine-disrupting compounds; oxidative stress;
   non-alcoholic fatty liver disease; hepatocellular carcinoma
ID PERINATAL EXPOSURE; GENE-EXPRESSION; LIPID-ACCUMULATION;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; METABOLISM; ACTIVATION; HEALTH;
   BPA
AB Non-alcoholic fatty liver disease (NAFLD) is considered a predominant chronic liver disease worldwide and a component of metabolic syndrome. Due to its relationship with multiple organs, it is extremely complex to precisely define its pathogenesis as well as to set appropriate therapeutic and preventive strategies. Endocrine disruptors (EDCs) in general, and bisphenol A (BPA) in particular, are a heterogeneous group of substances, largely distributed in daily use items, able to interfere with the normal signaling of several hormones that seem to be related to type 2 diabetes mellitus (T2DM), obesity, and other metabolic disorders. It is reasonable to hypothesize a BPA involvement in the pathogenesis and evolution of NAFLD. However, its mechanisms of action as well as its burden in the vicious circle that connects obesity, T2DM, metabolic syndrome, and NAFLD still remain to be completely defined. In this review we analyzed the scientific evidence on this promising research area, in order to provide an overview of the harmful effects linked to the exposure to EDCs as well as to frame the role that BPA would have in all phases of NAFLD evolution.
C1 [Dallio, Marcello; Gravina, Antonietta Gerarda; Patane, Vittorio; Romeo, Mario; Di Sarno, Rosa; Loguercio, Carmelina; Federico, Alessandro] Univ Campania Luigi Vanvitelli, Dept Precis Med, Via Pansini 5, I-80131 Naples, Italy.
   [Diano, Nadia; Errico, Sonia; Nicolucci, Carla] Univ Campania Luigi Vanvitelli, Dept Expt Med, Via Pansini 5, I-80131 Naples, Italy.
   [Masarone, Mario; Persico, Marcello] Univ Salerno, Dept Med & Surg, Via Salvador Allende, I-84081 Salerno, Italy.
   [Abenavoli, Ludovico] Magna Graecia Univ Catanzaro, Dept Hlth Sci, Viale Europa Germaneto, I-88110 Catanzaro, Italy.
   [Scarpellini, Emidio] Univ Hosp Gasthuisberg, Dept Internal Med, Div Gastroenterol, TARGID, B-3000 Leuven, Belgium.
   [Boccuto, Luigi] Greenwood Genet Ctr, 113 Gregor Mendel Circle, Greenwood, SC 29646 USA.
C3 Universita della Campania Vanvitelli; Universita della Campania
   Vanvitelli; University of Salerno; Magna Graecia University of
   Catanzaro; KU Leuven; University Hospital Leuven; Greenwood Genetic
   Center
RP Dallio, M (corresponding author), Univ Campania Luigi Vanvitelli, Dept Precis Med, Via Pansini 5, I-80131 Naples, Italy.
EM marcello.dallio@gmail.com
RI Abenavoli, Ludovico/J-4394-2019; Gravina, Antonietta
   Gerarda/AAC-1528-2019; Scarpellini, Emidio/AAT-2052-2020; Diano,
   Nadia/AAS-7358-2021; Patane, Vittorio/NEU-0770-2025; Dallio,
   Marcello/ABG-7693-2020; persico, marcello/AAB-3562-2019; Federico,
   Alessandro/AAB-3893-2019; Masarone, Mario/H-8633-2017; ,
   Vittorio/JNR-9856-2023
OI Scarpellini, Emidio/0000-0002-2101-1118; Persico,
   Marcello/0000-0002-1399-6498; MONTEBIANCO ABENAVOLI,
   Ludovico/0000-0002-5922-1524; Romeo, Mario/0000-0002-2970-9019;
   Masarone, Mario/0000-0003-0550-8201; Diano, Nadia/0000-0003-4433-2667;
   DALLIO, MARCELLO/0000-0003-4153-815X; Federico,
   Alessandro/0000-0002-0885-0793; , Vittorio/0000-0003-0767-3884
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NR 72
TC 44
Z9 44
U1 3
U2 22
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-7827
EI 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD SEP 1
PY 2019
VL 16
IS 17
AR 3134
DI 10.3390/ijerph16173134
PG 16
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA IZ4EQ
UT WOS:000487037500129
PM 31466361
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Chen, YC
   Sheen, JM
   Tiao, MM
   Tain, YL
   Huang, LT
AF Chen, Yu-Chieh
   Sheen, Jiunn-Ming
   Tiao, Miao-Meng
   Tain, You-Lin
   Huang, Li-Tung
TI Roles of Melatonin in Fetal Programming in Compromised Pregnancies
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE melatonin; epigenetic; fetal programming; redox; pregnancy
ID ALTERED EPIGENETIC REGULATION; BROWN ADIPOSE-TISSUE; OXIDATIVE STRESS;
   GLUCOCORTICOID-RECEPTOR; DEVELOPMENTAL ORIGINS; METABOLIC SYNDROME;
   PINEAL-GLAND; MATERNAL PINEALECTOMY; VASCULAR DYSFUNCTION; ANTIOXIDANT
   ENZYMES
AB Compromised pregnancies such as those associated with gestational diabetes mellitus, intrauterine growth retardation, preeclampsia, maternal undernutrition, and maternal stress may negatively affect fetal development. Such pregnancies may induce oxidative stress to the fetus and alter fetal development through the epigenetic process that may affect development at a later stage. Melatonin is an oxidant scavenger that reverses oxidative stress during the prenatal period. Moreover, the role of melatonin in epigenetic modifications in the field of developmental programming has been studied extensively. Here, we describe the physiological function of melatonin in pregnancy and discuss the roles of melatonin in fetal programming in compromised pregnancies, focusing on its involvement in redox and epigenetic mechanisms.
C1 [Chen, Yu-Chieh; Sheen, Jiunn-Ming; Tiao, Miao-Meng; Tain, You-Lin; Huang, Li-Tung] Chang Gung Univ, Dept Pediat, Kaohsiung Chang Gung Mem Hosp, Coll Med, Kaohsiung 833, Taiwan.
   [Tain, You-Lin] Chang Gung Univ, Ctr Translat Res Biomed Sci, Kaohsiung Chang Gung Mem Hosp, Coll Med, Kaohsiung 833, Taiwan.
   [Huang, Li-Tung] Chang Gung Univ, Dept Tradit Chinese Med, Linkow 333, Taiwan.
C3 Chang Gung University; Chang Gung Memorial Hospital; Chang Gung
   University; Chang Gung Memorial Hospital
RP Huang, LT (corresponding author), Chang Gung Univ, Dept Pediat, Kaohsiung Chang Gung Mem Hosp, Coll Med, Kaohsiung 833, Taiwan.
EM gesicht27@gmail.com; ray.sheen@gmail.com; pc006581@yahoo.com.tw;
   tainyl@hotmail.com; huang_li@pie.com.tw
RI Tsai, Ming/ABA-9806-2020; Tain, You-Lin/H-2827-2019
OI Tain, You-Lin/0000-0002-7059-6407; Tiao, Mao-Meng/0000-0002-0338-3495
FU Chang Gung Memorial Hospital, Kaohsiung, Taiwan [CMRPG8B0301]
FX The study was supported by the grant CMRPG8B0301 from Chang Gung
   Memorial Hospital, Kaohsiung, Taiwan to Li-Tung Huang.
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NR 149
TC 71
Z9 74
U1 0
U2 28
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD MAR
PY 2013
VL 14
IS 3
BP 5380
EP 5401
DI 10.3390/ijms14035380
PG 22
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 112RH
UT WOS:000316609800052
PM 23466884
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Portugal-Nunes, C
   Reis, J
   Coelho, A
   Moreira, PS
   Castanho, TC
   Magalhaes, R
   Marques, P
   Soares, JM
   Amorim, L
   Cunha, PG
   Santos, NC
   Costa, P
   Palha, JA
   Sousa, N
   Bessa, JM
AF Portugal-Nunes, Carlos
   Reis, Joana
   Coelho, Ana
   Moreira, Pedro Silva
   Castanho, Teresa Costa
   Magalhaes, Ricardo
   Marques, Paulo
   Soares, Jose Miguel
   Amorim, Liliana
   Cunha, Pedro Guimaraes
   Santos, Nadine Correia
   Costa, Patricio
   Palha, Joana Almeida
   Sousa, Nuno
   Bessa, Joao Miguel
TI The Association of Metabolic Dysfunction and Mood Across Lifespan
   Interacts With the Default Mode Network Functional Connectivity
SO FRONTIERS IN AGING NEUROSCIENCE
LA English
DT Article
DE metabolic dysfunction; mood; age; functional connectivity; default mode
   network
ID MAJOR DEPRESSIVE DISORDER; LOW BLOOD-PRESSURE; BODY-MASS INDEX;
   INSULIN-RESISTANCE; METAANALYSIS; ANXIETY; RISK; DISEASE; OBESITY;
   HEALTH
AB Background: Numerous studies suggest a relationship between depression and metabolic syndrome, which is likely influenced by age. Interestingly, functional imaging analysis has shown an association between functional connectivity in the default mode network (DMN-FC) and components of metabolic syndrome, which is explored in this study.
   Methods: From a larger longitudinal cohort study on healthy aging, 943 individuals were extensively characterized for mood and cognition. Among these, 120 individuals who were selected for displaying extreme cognitive performance within the normal range (good and poor performers) were further studied. Here, in a cross-sectional design, using confirmatory factor analysis (CFA), the association between metabolic dysfunction and depressive mood as a function of age and its relationship with DMN-FC was studied.
   Results: Metabolic dysfunction was modeled as a second-order latent variable using CFA. First-order latent variables were obesity, glucose dysmetabolism, lipids imbalance, and blood pressure. Using multiple linear regression models, this study observed that metabolic dysfunction, glucose dysmetabolism, and lipids imbalance were linearly associated with depressive mood, and the association with obesity was U-shaped. The association of metabolic dysfunction, obesity, and glucose dysmetabolism with depressive mood is positive for the younger individuals in our sample and vanishes with aging. The FC of the right superior temporal gyrus with the DMN correlated with both obesity and depressive mood. In participants with higher obesity scores, FC increased with higher GDS scores, while in those with lower GDS scores, FC decreased. Age and blood pressure were associated with a more complex pattern of association between FC of the right supramarginal gyrus and GDS score.
   Conclusion: The association of metabolic dysfunction with depressive mood is influenced by age and relates with differential patterns of DMN-FC. The combination of the effects of age, mood, and metabolic dysfunction is likely to explain the heterogeneity of DMN-FC, which deserves further investigation with larger and longitudinal studies.
C1 [Portugal-Nunes, Carlos; Reis, Joana; Coelho, Ana; Moreira, Pedro Silva; Castanho, Teresa Costa; Magalhaes, Ricardo; Marques, Paulo; Soares, Jose Miguel; Amorim, Liliana; Cunha, Pedro Guimaraes; Santos, Nadine Correia; Costa, Patricio; Palha, Joana Almeida; Sousa, Nuno; Bessa, Joao Miguel] Univ Minho, Sch Hlth Sci, Life & Hlth Sci Res Inst ICVS, Braga, Portugal.
   [Portugal-Nunes, Carlos; Reis, Joana; Coelho, Ana; Moreira, Pedro Silva; Castanho, Teresa Costa; Magalhaes, Ricardo; Marques, Paulo; Soares, Jose Miguel; Amorim, Liliana; Cunha, Pedro Guimaraes; Santos, Nadine Correia; Costa, Patricio; Palha, Joana Almeida; Sousa, Nuno; Bessa, Joao Miguel] PT Govt Assoc Lab, ICVS 3Bs, Braga, Portugal.
   [Portugal-Nunes, Carlos; Reis, Joana; Coelho, Ana; Moreira, Pedro Silva; Castanho, Teresa Costa; Magalhaes, Ricardo; Marques, Paulo; Soares, Jose Miguel; Amorim, Liliana; Santos, Nadine Correia; Costa, Patricio; Palha, Joana Almeida; Sousa, Nuno; Bessa, Joao Miguel] Clin Acad Ctr Braga, Braga, Portugal.
   [Moreira, Pedro Silva] Univ Minho, Sch Psychol, CIPsi, Psychol Neurosci Lab, Braga, Portugal.
   [Cunha, Pedro Guimaraes] Ctr Hosp Alto Ave EPE, Guimaraes, Portugal.
C3 Universidade do Minho; Laboratorio Associado ICVS 3B's; Universidade do
   Minho
RP Bessa, JM (corresponding author), Univ Minho, Sch Hlth Sci, Life & Hlth Sci Res Inst ICVS, Braga, Portugal.; Bessa, JM (corresponding author), PT Govt Assoc Lab, ICVS 3Bs, Braga, Portugal.; Bessa, JM (corresponding author), Clin Acad Ctr Braga, Braga, Portugal.
EM joaobessa@med.uminho.pt
RI Amorim, Liliana/Q-7807-2019; Moreira, Pedro/E-4471-2018; Junior,
   Jose/KHC-8978-2024; Sousa, Nuno/N-9137-2017; Cunha, Pedro/AAE-6732-2019;
   Palha, Joana/C-2745-2009; Magalhães, Ricardo/Q-7995-2018; Coelho,
   Ana/T-5310-2018; Castanho, Teresa/T-5279-2018; Cunha, Pedro/K-6743-2014;
   Costa, Patricio/A-3072-2013; Bessa, Joao/K-8079-2014; Correia Santos,
   Nadine/K-7431-2015; Portugal-Nunes, Carlos/AGW-4051-2022
OI Coelho, Ana/0000-0001-8489-5750; Castanho, Teresa/0000-0002-4162-0359;
   Cunha, Pedro/0000-0002-8518-4130; Costa, Patricio/0000-0002-1201-9177;
   Reis, Joana/0000-0002-1240-6388; Bessa, Joao/0000-0001-6385-2452;
   Correia Santos, Nadine/0000-0001-8110-7173; Portugal-Nunes,
   Carlos/0000-0001-8398-1366; Soares, Jose Miguel/0000-0001-6558-4973;
   Amorim, Liliana/0000-0002-5105-7045
FU Foundation for Science and Technology (FCT) [UIDB/50026/2020,
   UIDP/50026/2020]; Norte Portugal Regional Operational Programme (NORTE
   2020), under the PORTUGAL 2020 Partnership Agreement, through the
   European Regional Development Fund (ERDF) [NORTE-01-0145-FEDER-000013,
   NORTE-01-0145-FEDER-000023]; European Commission (FP7) SwitchBox
   [HEALTH-F2-2010-259772]; Portuguese North Regional Operational Program
   (ON.2-O Novo Norte) under the National Strategic Reference Framework
   (QREN), through the European Regional Development Fund (FEDER); Fundacao
   Calouste Gulbenkian-Inovar em Saude (Envelhecimento cognitivo
   saudavel-proporcionar saude mental no processo biologico do
   envelhecimento) [P-139977]; Portuguese Foundation for Science and
   Technology (FCT) [PTDC/DTP-PIC/6936/2014, SFRH/BD/90078/2012,
   SFRH/BD/101398/2014]; Portuguese Science Foundation (FCT)
   [PD/BD/106050/2015]; NORTE 2020 [UMINHO/BD/51/2017]; FCT from PhDiHES
   program [PDE/BDE/113601/2015, PDE/BDE/113602/2015, PDE/BDE/113604/2015];
   Fundacao Calouste Gulbenkian (Portugal) [P-139977]; Research
   Assistantship through the FCT Investigator Programme 2008Ciencia; 
   [NORTE-08-5639-FSE-000041]; Fundação para a Ciência e a Tecnologia
   [PTDC/DTP-PIC/6936/2014, PD/BD/106050/2015, SFRH/BD/101398/2014] Funding
   Source: FCT
FX This work has been funded by National funds, through the Foundation for
   Science and Technology (FCT)-project UIDB/50026/2020 and
   UIDP/50026/2020; and by the projects NORTE-01-0145-FEDER-000013 and
   NORTE-01-0145-FEDER-000023, supported by Norte Portugal Regional
   Operational Programme (NORTE 2020), under the PORTUGAL 2020 Partnership
   Agreement, through the European Regional Development Fund (ERDF), by the
   European Commission (FP7) SwitchBox (Contract HEALTH-F2-2010-259772)
   project and co-financed by the Portuguese North Regional Operational
   Program (ON.2-O Novo Norte) under the National Strategic Reference
   Framework (QREN), through the European Regional Development Fund
   (FEDER), and by Fundacao Calouste Gulbenkian-Inovar em Saude
   (Envelhecimento cognitivo saudavel-proporcionar saude mental no processo
   biologico do envelhecimento, Contract P-139977) and by the Portuguese
   Foundation for Science and Technology (FCT) under the project
   PTDC/DTP-PIC/6936/2014. CP-N was supported by the Portuguese Science
   Foundation (FCT) doctoral scholarship PD/BD/106050/2015 via
   Inter-University PhD Programme in Aging and Chronic Diseases. JR was
   supported by the FCT fellowship grant with the reference
   PDE/BDE/113602/2015 from the PhDiHES program. AC was supported by a
   scholarship from the project NORTE-08-5639-FSE-000041 (NORTE 2020;
   UMINHO/BD/51/2017). PSM was supported by the FCT fellowship grant with
   the reference PDE/BDE/113601/2015 from the PhDiHES program. TC was a
   recipient of a doctoral fellowship from the Portuguese Foundation for
   Science and Technology (FCT; SFRH/BD/90078/2012). RM was supported by
   the FCT fellowship grant with the reference PDE/BDE/113604/2015 from the
   PhDiHES program. PM was supported by the Fundacao Calouste Gulbenkian
   (Portugal) grant number: P-139977: Better mental health during aging
   based on temporal prediction of individual brain aging trajectories
   (TEMPO). LA was a recipient of a doctoral fellowship from the Portuguese
   Foundation for Science and Technology (FCT; SFRH/BD/101398/2014). NS was
   a recipient of a Research Assistantship through the FCT Investigator
   Programme 2008Ciencia.
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NR 60
TC 4
Z9 4
U1 0
U2 6
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1663-4365
J9 FRONT AGING NEUROSCI
JI Front. Aging Neurosci.
PD AUG 2
PY 2021
VL 13
AR 618623
DI 10.3389/fnagi.2021.618623
PG 13
WC Geriatrics & Gerontology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Neurosciences & Neurology
GA UL9DA
UT WOS:000692942200001
PM 34408637
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Huang, JY
   Gavin, AR
   Richardson, TS
   Rowhani-Rahbar, A
   Siscovick, DS
   Hochner, H
   Friedlander, Y
   Enquobahrie, DA
AF Huang, Jonathan Y.
   Gavin, Amelia R.
   Richardson, Thomas S.
   Rowhani-Rahbar, Ali
   Siscovick, David S.
   Hochner, Hagit
   Friedlander, Yechiel
   Enquobahrie, Daniel A.
TI Accounting for Life-Course Exposures in Epigenetic Biomarker Association
   Studies: Early Life Socioeconomic Position, Candidate Gene DNA
   Methylation, and Adult Cardiometabolic Risk
SO AMERICAN JOURNAL OF EPIDEMIOLOGY
LA English
DT Article
DE epigenetic biomarker; life course; marginal structural models;
   methylation; time-dependent confounding
ID MARGINAL STRUCTURAL MODELS; BIRTH-WEIGHT; IN-UTERO;
   GLUCOCORTICOID-RECEPTOR; PRENATAL EXPOSURE; MATERNAL SMOKING; HUMAN
   HYPERTENSION; MASS-SPECTROMETRY; HEALTH; DISEASE
AB Recent studies suggest that epigenetic programming may mediate the relationship between early life environment, including parental socioeconomic position, and adult cardiometabolic health. However, interpreting associations between early environment and adult DNA methylation may be difficult because of time-dependent confounding by life-course exposures. Among 613 adult women (mean age = 32 years) of the Jerusalem Perinatal Study Family Follow-up (2007-2009), we investigated associations between early life socioeconomic position (paternal occupation and parental education) and mean adult DNA methylation at 5 frequently studied cardiometabolic and stress-response genes (ABCA1, INS-IGF2, LEP, HSD11B2, and NR3C1). We used multivariable linear regression and marginal structural models to estimate associations under 2 causal structures for life-course exposures and timing of methylation measurement. We also examined whether methylation was associated with adult cardiometabolic phenotype. Higher maternal education was consistently associated with higher HSD11B2 methylation (e.g., 0.5%-point higher in 9-12 years vs. <= 8 years, 95% confidence interval: 0.1, 0.8). Higher HSD11B2 methylation was also associated with lower adult weight and total and low-density lipoprotein cholesterol. We found that associations with early life socioeconomic position measures were insensitive to different causal assumption; however, exploratory analysis did not find evidence for a mediating role of methylation in socioeconomic position-cardiometabolic risk associations.
C1 [Huang, Jonathan Y.] McGill Univ, Policy, Montreal, PQ, Canada.
   [Gavin, Amelia R.] Univ Washington, Sch Social Work, Seattle, WA 98195 USA.
   [Richardson, Thomas S.] Univ Washington, Dept Stat, Seattle, WA 98195 USA.
   [Siscovick, David S.] New York Acad Med, New York, NY USA.
   [Hochner, Hagit; Friedlander, Yechiel] Hebrew Univ Jerusalem, Hadassah Med Ctr, Braun Sch Publ Hlth, Jerusalem, Israel.
C3 McGill University; University of Washington; University of Washington
   Seattle; University of Washington; University of Washington Seattle; New
   York Academy of Medicine; Hebrew University of Jerusalem; Hadassah
   University Medical Center; Hadassah University Hospital
RP Huang, JY (corresponding author), McGill Univ, Inst Hlth & Social Policy, Montreal Hlth Equ Res Consortium, 1130 Pine Ave West, Montreal, PQ H3A 1A3, Canada.
EM jon.huang@mcgill.ca
RI Huang, Jonathan/J-4139-2019; Richardson, Thomas/HNC-0431-2023; Gavin,
   Amelia/AAX-1229-2021; Hochner, Hagit/KAM-0739-2024
OI Hochner, Hagit/0000-0002-8853-2276; Huang, Jonathan/0000-0002-5901-8403;
   Rowhani-Rahbar, Ali/0000-0002-2705-4485
FU University of Washington Global Women, Adolescents, and Children
   Integrated Health Seed Grant; Israeli Science Foundation [1252/07,
   552/12]; National Institutes of Health [T32HD052462, K01HL103174,
   R01HL088884]; Canadian Institutes of Health Research [115214]
FX This work was supported by the University of Washington Global Women,
   Adolescents, and Children Integrated Health Seed Grant 2013-2014;
   Israeli Science Foundation grants 1252/07 and 552/12; National
   Institutes of Health grants T32HD052462, K01HL103174, and R01HL088884;
   and Canadian Institutes of Health Research operating grant 115214,
   "Ethics, Social Determinants of Health, and Health Equity: Integrating
   Theory and Practice," although no direct funding was received or set
   aside for the writing of this paper.
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NR 69
TC 25
Z9 28
U1 0
U2 17
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0002-9262
EI 1476-6256
J9 AM J EPIDEMIOL
JI Am. J. Epidemiol.
PD OCT 1
PY 2016
VL 184
IS 7
BP 520
EP 531
DI 10.1093/aje/kww014
PG 12
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA EA4AY
UT WOS:000386552000005
PM 27651384
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Lengvenyte, A
   Aouizerate, B
   Aubin, V
   Loftus, J
   Marlinge, E
   Belzeaux, R
   Dubertret, C
   Gard, S
   Haffen, E
   Schwan, R
   Llorca, PM
   Passerieux, C
   Roux, P
   Polosan, M
   Etain, B
   Leboyer, M
   Courtet, P
   Olié, E
AF Lengvenyte, Aiste
   Aouizerate, Bruno
   Aubin, Valerie
   Loftus, Josephine
   Marlinge, Emeline
   Belzeaux, Raoul
   Dubertret, Caroline
   Gard, Sebastien
   Haffen, Emmanuel
   Schwan, Raymund
   Llorca, Pierre-Michel
   Passerieux, Christine
   Roux, Paul
   Polosan, Mircea
   Etain, Bruno
   Leboyer, Marion
   Courtet, Philippe
   Olie, Emilie
CA FondaMental Adv Ctr Expertise Bipo
TI Violent suicide attempt history in elderly patients with bipolar
   disorder: The role of sex, abdominal obesity, and verbal memory: Results
   from the FACE-BD cohort (FondaMental Advanced center of Expertise for
   Bipolar Disorders)
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Suicide; Bipolar disorder; Obesity; Cognitive function; Memory; Cohort
ID BODY-MASS INDEX; METABOLIC SYNDROME; GENDER-DIFFERENCES; WAIST
   CIRCUMFERENCE; COMPLETED SUICIDE; DECISION-MAKING; WEIGHT STIGMA;
   HEALTH; DEPRESSION; STRESS
AB Background: Bipolar disorder (BD) is a chronic, lifelong condition, associated with increased risk of obesity, cognitive impairment, and suicidal behaviors. Abdominal obesity and a higher risk of violent suicide attempt (SA) seem to be shared correlates with older age, BD, and male sex until middle age when menopause-related female body changes occur. This study aimed at assessing the role of abdominal obesity and cognition in the violent SA burden of individuals with BD.
   Methods: From the well-defined nationwide cohort FACE-BD (FondaMental Advanced center of Expertise for Bipolar Disorders), we extracted data on 619 euthymic BD patients that were 50 years or older at inclusion. Cross-sectional clinical, cognitive, and metabolic assessments were performed. SA history was based on self-report.
   Results: Violent SA, in contrast to non-violent and no SA, was associated with higher waist circumference, abdominal obesity and poorer California Verbal Learning Test short-delay free recall (CVLT-SDFR) (ANOVA, p < 001, p = .014, and p = .006). Waist circumference and abdominal obesity were associated with violent SA history independently of sex, BD type and anxiety disorder (Exp(B) 1.02, CI 1.00-1.05, p = .018; Exp(B) 2.16, CI 1.00-4.64, p = .009, accordingly). In an exploratory model, waist circumference and CVLT-SDFR performance mediated the association between male sex and violent SA.
   Limitations: Cross-sectional design and retrospective reporting.
   Conclusions: Violent SA history was associated with abdominal obesity and poorer verbal memory in older age BD patients. These factors were interlinked and might mediate the association between male sex and violent SA.
C1 [Lengvenyte, Aiste; Courtet, Philippe; Olie, Emilie] Univ Montpellier, Dept Emergency Psychiat & Postacute Care, INSERM, CHU Montpellier,IGF,CNRS, 371 Av Doyen Gaston Giraud, F-34090 Montpellier, France.
   [Lengvenyte, Aiste; Aouizerate, Bruno; Loftus, Josephine; Marlinge, Emeline; Belzeaux, Raoul; Dubertret, Caroline; Gard, Sebastien; Haffen, Emmanuel; Schwan, Raymund; Llorca, Pierre-Michel; Passerieux, Christine; Roux, Paul; Polosan, Mircea; Etain, Bruno; Leboyer, Marion; Courtet, Philippe; Olie, Emilie] Fdn FondaMental, Creteil, France.
   [Lengvenyte, Aiste] Vilnius Univ, Fac Med, Inst Clin Med, Psychiat Clin, Vilnius, Lithuania.
   [Aouizerate, Bruno; Gard, Sebastien] Charles Perrens Hosp, Dept Clin & Acad Psychiat, Bordeaux, France.
   [Aouizerate, Bruno] Univ Bordeaux, France NutriNeuro, UMR INRAE 1286, Bordeaux, France.
   [Aubin, Valerie; Loftus, Josephine] Hosp Princess Grace, Psychiat Ctr, Monaco, Monaco.
   [Marlinge, Emeline; Etain, Bruno] Univ Paris, Hop Fernand Widal, AP HP, DMU Neurosci,GHU Paris Nord,INSERM UMRS 1144, Paris, France.
   [Belzeaux, Raoul] AP HM, Pole Psychiat, Marseille, France.
   [Belzeaux, Raoul] Aix Marseille Univ, INT UMR7289, CNRS, Marseille, France.
   [Dubertret, Caroline] Univ Paris, Grp Hosp Univ AP HP Nord, Hop Louis Mourier,AP HP, Serv Psychiat & Addictol,Fac Med,DMU ESPRIT, Colombes, France.
   [Haffen, Emmanuel] Univ Franche Comte, Serv Psychiat Adulte, Lab Neurosci, CHU Besancon,UBFC,CIC 1431 INSERM, Besancon, France.
   [Schwan, Raymund] Univ Lorraine, Pole Hosp Univ Psychiat Adultes Grand Nancy, Ctr Psychotherap Nancy, INSERM U1114, Nancy, France.
   [Llorca, Pierre-Michel] Univ Clermont Auvergne, Dept Psychiat, CHU Clermont Ferrand, EA 7280, Clermont Ferrand, France.
   [Passerieux, Christine; Polosan, Mircea] Univ Paris Saclay, Serv Univ Psychiat Adulte & Addictol, Ctr Hosp Versailles,Le Chesnay,DisAP DevPsy CESP, INSERM UMR1018,Univ Versailles St Quentin En Yvel, F-94807 Villejuif, France.
   [Roux, Paul; Leboyer, Marion] Univ Paris Est Creteil, AP HP, FHU ADAPT,INSERM,IMRB, DMU IMPACT,Fdn FondaMental,Translat Neuropsychiat, F-94010 Creteil, France.
C3 Universite de Montpellier; CHU de Montpellier; Centre National de la
   Recherche Scientifique (CNRS); Institut National de la Sante et de la
   Recherche Medicale (Inserm); Vilnius University; INRAE; Universite de
   Bordeaux; Universite Paris Cite; Institut National de la Sante et de la
   Recherche Medicale (Inserm); Assistance Publique Hopitaux Paris (APHP);
   Hopital Universitaire Saint-Louis - APHP; Hopital Universitaire
   Lariboisiere-Fernand-Widal - APHP; Aix-Marseille Universite; Assistance
   Publique-Hopitaux de Marseille; Aix-Marseille Universite; Centre
   National de la Recherche Scientifique (CNRS); CNRS - National Institute
   for Biology (INSB); Assistance Publique Hopitaux Paris (APHP);
   Universite Paris Cite; Hopital Universitaire Louis-Mourier - APHP;
   Institut National de la Sante et de la Recherche Medicale (Inserm);
   Universite de Franche-Comte; CHU Besancon; Universite de Lorraine;
   Institut National de la Sante et de la Recherche Medicale (Inserm);
   Universite Clermont Auvergne (UCA); CHU Clermont Ferrand; Institut
   National de la Sante et de la Recherche Medicale (Inserm); Universite
   Paris Saclay; Centre Hospitalier de Versailles; Universite
   Paris-Est-Creteil-Val-de-Marne (UPEC); Assistance Publique Hopitaux
   Paris (APHP); Hopital Universitaire Henri-Mondor - APHP; Institut
   National de la Sante et de la Recherche Medicale (Inserm)
RP Lengvenyte, A (corresponding author), Univ Montpellier, Dept Emergency Psychiat & Postacute Care, INSERM, CHU Montpellier,IGF,CNRS, 371 Av Doyen Gaston Giraud, F-34090 Montpellier, France.
EM aiste.lengvenyte@chu-montpellier.fr
RI Lengvenyte, Aiste/AAI-1328-2020; Fond, Guillaume/D-7646-2011; Roux,
   Paul/B-5795-2013; Polosan, Mircea/MGV-2270-2025; Schwan,
   Raymund/AAA-5230-2022; Belzeaux, Raoul/AGZ-3125-2022; Etain,
   Bruno/L-6647-2017; haffen, emmanuel/R-2765-2017
OI Aouizerate, Bruno/0000-0002-7092-7747; Lengvenyte,
   Aiste/0000-0001-9715-5145; AUBIN, VALERIE/0000-0002-2444-0954; Etain,
   Bruno/0000-0002-5377-1488; haffen, emmanuel/0000-0002-4091-518X
FU Fondation FondaMental, Creteil, France; Investissements d'Avenir
   programs [ANR-11-IDEX-0004-02, ANR-10-COHO-10-01]
FX This work was supported (in part) by the Fondation FondaMental, Creteil,
   France and by the Investissements d'Avenir programs managed by the ANR
   under references ANR-11-IDEX-0004-02 and ANR-10-COHO-10-01
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NR 95
TC 7
Z9 7
U1 1
U2 8
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD JAN 1
PY 2022
VL 296
BP 265
EP 276
DI 10.1016/j.jad.2021.09.097
EA OCT 2021
PG 12
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA XO1QU
UT WOS:000729968500034
PM 34606799
OA Green Submitted, Bronze
DA 2025-06-11
ER

PT J
AU Asghar, ZA
   Thompson, A
   Chi, M
   Cusumano, A
   Scheaffer, S
   Al-Hammadi, N
   Saben, JL
   Moley, KH
AF Asghar, Zeenat A.
   Thompson, Alysha
   Chi, Maggie
   Cusumano, Andrew
   Scheaffer, Suzanne
   Al-Hammadi, Noor
   Saben, Jessica L.
   Moley, Kelle H.
TI Maternal fructose drives placental uric acid production leading to
   adverse fetal outcomes
SO SCIENTIFIC REPORTS
LA English
DT Article
ID OXIDATIVE STRESS; METABOLIC SYNDROME; HEPATIC STEATOSIS; DIETARY
   FRUCTOSE; FATTY LIVER; PREGNANCY; CONSUMPTION; RISK; LACTATION; SUGAR
AB Maternal metabolic diseases increase offspring risk for low birth weight and cardiometabolic diseases in adulthood. Excess fructose consumption may confer metabolic risks for both women and their offspring. However, the direct consequences of fructose intake per se are unknown. We assessed the impact of a maternal high-fructose diet on the fetal-placental unit in mice in the absence of metabolic syndrome and determined the association between maternal serum fructose and placental uric acid levels in humans. In mice, maternal fructose consumption led to placental inefficiency, fetal growth restriction, elevated fetal serum glucose and triglyceride levels. In the placenta, fructose induced de novo uric acid synthesis by activating the activities of the enzymes AMP deaminase and xanthine oxidase. Moreover, the placentas had increased lipids and altered expression of genes that control oxidative stress. Treatment of mothers with the xanthine oxidase inhibitor allopurinol reduced placental uric acid levels, prevented placental inefficiency, and improved fetal weights and serum triglycerides. Finally, in 18 women delivering at term, maternal serum fructose levels significantly correlated with placental uric acid levels. These findings suggest that in mice, excess maternal fructose consumption impairs placental function via a xanthine oxidase/uric acid-dependent mechanism, and similar effects may occur in humans.
C1 [Asghar, Zeenat A.; Thompson, Alysha; Chi, Maggie; Cusumano, Andrew; Scheaffer, Suzanne; Saben, Jessica L.; Moley, Kelle H.] Washington Univ, Sch Med, Dept Obstet & Gynecol, St Louis, MO 63110 USA.
   [Al-Hammadi, Noor] Washington Univ, Sch Med, Dept Biostat, St Louis, MO USA.
C3 Washington University (WUSTL); Washington University (WUSTL)
RP Saben, JL; Moley, KH (corresponding author), Washington Univ, Sch Med, Dept Obstet & Gynecol, St Louis, MO 63110 USA.
EM sabenj@wudosis.wustl.edu; moleyk@wudosis.wustl.edu
RI Saben, Jessica/IUO-1267-2023; Al-Hammadi, Noor/E-5866-2019
OI Al-Hammadi, Noor/0000-0003-1742-6609; Shyr, Zeenat/0000-0001-8710-9938;
   saben, jessica/0000-0002-9873-025X
FU NIH [HD083895, HD065435]; American Diabetes Association; CTSA at
   Washington University [UL1 TR000448]; Thrasher Research Foundation
FX The authors thank Deborah Frank, PhD, Obstetrics and Gynecology,
   Washington University in St. Louis, for critical reading and editing of
   this manuscript. This work was supported by NIH grants HD083895 and
   HD065435 (KHM), a grant from the American Diabetes Association (KHM), a
   grant from the CTSA at Washington University (UL1 TR000448) (KHM, JLS),
   and the Thrasher Research Foundation (JLS).
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NR 53
TC 39
Z9 41
U1 2
U2 18
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD APR 29
PY 2016
VL 6
AR 25091
DI 10.1038/srep25091
PG 11
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA DK8QE
UT WOS:000375192100001
PM 27125896
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Cheung, O
   Sanyal, AJ
AF Cheung, Onpan
   Sanyal, Arun J.
TI Recent advances in nonalcoholic fatty liver disease
SO CURRENT OPINION IN GASTROENTEROLOGY
LA English
DT Review
DE de-novo lipogenesis; insulin resistance; metabolic syndrome;
   nonalcoholic steatohepatitis; oxidative stress
ID INSULIN-RESISTANCE; TRANSIENT ELASTOGRAPHY; HEPATIC STEATOSIS; RAT
   MODEL; GENE POLYMORPHISMS; METABOLIC SYNDROME; BARIATRIC SURGERY;
   PHYSICAL-ACTIVITY; ADIPOSE-TISSUE; X-RECEPTOR
AB Purpose of review
   This review focuses on recent advances in the study of the epidemiology, pathogenesis, natural history and treatment of nonalcoholic fatty liver disease (NAFLD).
   Recent findings
   Study of hepatic lipid metabolism with respect to the contribution of de-novo lipogenesis to hepatic steatosis and insulin resistance and the dysregulation of cellular adaptive response to stress, that is, the unfolded protein response has added to our current understanding of NAFLD. microRNA has recently emerged and has been shown to be differentially expressed in patients with nonalcoholic steatohepatitis. Its mechanism of action remains to be further explored. There is no proven pharmacotherapy for the treatment of NAFLD. Lifestyle intervention to achieve weight loss and increase exercise is persistently associated with improved liver histology. The diagnostic utility of noninvasive markers and imaging modalities in assessing fibrosis remains to be elucidated.
   Summary
   The underlying mechanism and pathogenesis of NAFLD remain elusive. Although research effort has advanced the understanding of the natural history, pathogenesis and management of the disease, there is no proven therapy for this medical condition. At present, treatment concentrates on managing underlying metabolic risk factors.
C1 [Cheung, Onpan; Sanyal, Arun J.] Virginia Commonwealth Univ, Med Ctr, Dept Internal Med, Div Gastroenterol Hepatol & Nutr, Richmond, VA USA.
C3 Virginia Commonwealth University
RP Sanyal, AJ (corresponding author), MCV Box 980341, Richmond, VA 23298 USA.
EM ajsanyal@hsc.vcu.edu
FU National Institutes of Health [K24 DK 02755-07]
FX The work was supported in part by a grant from the National Institutes
   of Health to Dr A.J.S. K24 DK 02755-07.
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NR 101
TC 51
Z9 62
U1 0
U2 11
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0267-1379
EI 1531-7056
J9 CURR OPIN GASTROEN
JI Curr. Opin. Gastroenterol.
PD MAY
PY 2009
VL 25
IS 3
BP 230
EP 237
DI 10.1097/MOG.0b013e3283294a18
PG 8
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 443EH
UT WOS:000265892500010
PM 19396962
DA 2025-06-11
ER

PT J
AU Huang, Q
   Wang, DH
   Chen, SS
   Tang, L
   Ma, CY
AF Huang, Qi
   Wang, Denghong
   Chen, Shanshan
   Tang, Lei
   Ma, Chaoyang
TI Association of METS-IR index with depressive symptoms in US adults: A
   cross-sectional study
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Depression; Insulin resistance; Cross-sectional study; NHANES; METS-IR
   index
ID ANTIDEPRESSANT MEDICATION USE; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   TYPE-2; SENSITIVITY; RISK; PIOGLITAZONE; EPIDEMIOLOGY; GLUCOSE; PHQ-9
AB Background: An association between insulin resistance (IR) and depression has been identified in recent years. The purpose of this study was to examine the relationship between IR and depression in the general population. Methods: The population for this cross-sectional study consisted of adults participating in the National Health and Nutrition Examination Survey (NHANES) between 2005 and 2018. Insulin sensitivity was assessed using the Metabolic Score for IR (METS-IR) index, while depression was evaluated using the Patient Health Questionnaire (PHQ)-9. Logistic regression analyses, subgroup analyses, and dose-response curves were conducted to assess the association between the METS-IR index and depression. Results: A total of 13,157 adults aged over 20 years were included in this study. After adjusting for potential confounders, it was observed that each unit increase in the METS-IR index was associated with a 1.1 percentage point increase in the prevalence of depression (OR = 1.011; 95 % CI: 1.008, 1.014). Patients in the 4th quartile of the METS-IR index had a higher likelihood of depression compared to those in the 1st quartile (OR = 1.386, 95 % CI: 1.239, 1.549). Stratified analyses demonstrated consistent results in all subgroups, except for men, patients under 40 years of age, and those with a history of cancer. Dose-response curves indicated a nonlinear relationship between the METS-IR index and the risk of depression, with an inflection point value of 32.443 according to threshold effect analysis. Conclusions: Our findings suggest that higher METS-IR scores are associated with an increased likelihood of experiencing depressive symptoms among U.S. adults.
C1 [Huang, Qi; Tang, Lei; Ma, Chaoyang] Huazhong Univ Sci & Technol, Cent Hosp Wuhan, Tongji Med Coll, Dept Rehabil, 26 Shengli St, Wuhan 430014, Peoples R China.
   [Wang, Denghong] Jianghan Univ, Wuhan Hosp 6, Dept Rehabil Med, Affiliated Hosp, Wuhan 430000, Hubei, Peoples R China.
   [Chen, Shanshan] Huazhong Univ Sci & Technol, Cent Hosp Wuhan, Tongji Med Coll, Key Lab Mol Diag Hubei Prov, Wuhan 430014, Peoples R China.
C3 Huazhong University of Science & Technology; Jianghan University;
   Huazhong University of Science & Technology
RP Tang, L; Ma, CY (corresponding author), Huazhong Univ Sci & Technol, Cent Hosp Wuhan, Tongji Med Coll, Dept Rehabil, 26 Shengli St, Wuhan 430014, Peoples R China.
EM tanglei125716@126.com; chaoyangm2023@163.com
RI Chen, Shanshan/AAO-2763-2020; tang, lei/JCO-4117-2023
FU Key Discipline Fund of Wuhan Central Hospital, Huazhong University of
   Science and Technology [2021XK040]
FX This work was supported by the Key Discipline Fund of Wuhan Central
   Hospital, Huazhong University of Science and Technology (No. 2021XK040)
   .
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NR 42
TC 10
Z9 10
U1 10
U2 24
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD JUN 15
PY 2024
VL 355
BP 355
EP 362
DI 10.1016/j.jad.2024.03.129
EA APR 2024
PG 8
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA RH9R3
UT WOS:001226896500001
PM 38554881
OA hybrid
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Tomas, E
   Stanojevic, V
   Habener, JF
AF Tomas, Eva
   Stanojevic, Violeta
   Habener, Joel F.
TI GLP-1-derived nonapeptide GLP-1(28-36)amide targets to mitochondria and
   suppresses glucose production and oxidative stress in isolated mouse
   hepatocytes
SO REGULATORY PEPTIDES
LA English
DT Article
DE Diabetes; Metabolic syndrome; Insulin resistance; Liver; NEP 24.11
ID GLUCAGON-LIKE PEPTIDE-1; GLP-1 9-36 AMIDE; NEUTRAL ENDOPEPTIDASE-24.11;
   INSULIN-RESISTANCE; METABOLITE; RECEPTOR; PROTEIN; DEGRADATION; IV
AB Background: Uncontrolled hepatic glucose production (gluconeogenesis), and glycogenolysis, is a major contributor to the fasting hyperglycemia associated with type 2 diabetes. Here we report the discovery of a C-terminal nonapeptide (FIAWLVKGRamide) derived from GLP-1 that suppresses glucose production and oxidative stress in isolated mouse hepatocytes. The nonapeptide, GLP-1(28-36)amide, was reported earlier to be a major product derived from the cleavage of GLP-1 by the endopeptidase NEP 24.11.
   Methods and results: Hepatocytes were isolated from the livers of normal and diet-induced obese mice. We find that the GLP-1(28-36)amide nonapeptide rapidly enters isolated mouse hepatocytes by GLP-1 receptor-independent mechanisms, and targets to mitochondria where it inhibits gluconeogenesis and oxidative stress.
   Conclusions: These findings suggest that GLP-1 not only acts on a cell surface G-protein coupled receptor activating kinase-regulated signaling pathways, but a small C-terminal peptide derived from GLP-1 also enters cells, targets mitochondria, and exerts insulin-like actions by modulating oxidative phosphorylation. GLP-1(28-36)amide, or a peptide mimetic derived there from, might prove to be a useful treatment for fasting hyperglycemia and metabolic syndrome in type 2 diabetes. (C) 2011 Elsevier B.V. All rights reserved.
C1 [Tomas, Eva; Stanojevic, Violeta; Habener, Joel F.] Massachusetts Gen Hosp, Mol Endocrinol Lab, Boston, MA 02114 USA.
C3 Harvard University; Harvard University Medical Affiliates; Massachusetts
   General Hospital
RP Habener, JF (corresponding author), Massachusetts Gen Hosp, Mol Endocrinol Lab, Boston, MA 02114 USA.
EM jhabener@partners.org
FU Merck Co.; Novo Nordisk
FX We thank Zhenghu Liu and Karen McManus for helpful comments and for help
   in the assays, and Robert Tyszkowski in the MGH PMB Microscopy Core for
   confocal imaging. Early phases of the studies were supported in part by
   a one-year Investigator Initiated Studies Program grant from Merck &
   Co.Later studies were supported in part by a Basic Science Grant from
   Novo Nordisk.
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NR 36
TC 84
Z9 98
U1 0
U2 9
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0167-0115
EI 1873-1686
J9 REGUL PEPTIDES
JI Regul. Pept.
PD APR 11
PY 2011
VL 167
IS 2-3
BP 177
EP 184
DI 10.1016/j.regpep.2011.01.003
PG 8
WC Endocrinology & Metabolism; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Physiology
GA 755JT
UT WOS:000289927000004
PM 21256872
DA 2025-06-11
ER

PT J
AU Sevilla-González, MD
   Quintana-Mendoza, BM
   Aguilar-Salinas, CA
AF del Rocio Sevilla-Gonzalez, Magdalena
   Macale Quintana-Mendoza, Brenda
   Alberto Aguilar-Salinas, Carlos
TI Interaction Between Depression, Obesity, and Type 2 Diabetes: A Complex
   Picture
SO ARCHIVES OF MEDICAL RESEARCH
LA English
DT Review
DE Depression; Obesity; Type 2 diabetes; Body weight
ID BODY-MASS INDEX; DIETARY PATTERNS; GLYCEMIC CONTROL;
   PSYCHIATRIC-DISORDERS; METABOLIC SYNDROME; BARIATRIC SURGERY;
   PHYSICAL-ACTIVITY; WEIGHT-LOSS; RISK-FACTOR; SYMPTOMS
AB Depression plays an important role in the pathogenesis and treatment of obesity and type 2 diabetes (T2D). However, its relevance is frequently unrecognized by clinicians and researchers. The purpose of this review is to present a critical analysis of the evidence linking depression and metabolic disorders and to highlight the practical implications of this complex relationship. Evidence obtained from epidemiological, basic, clinical and controlled studies demonstrate that the association goes beyond a random phenomenon. Epidemiological studies have rendered controversial results due to the lack of control of the confounding variables and the bidirectional relationship that exists between the outcomes and the conditions that modulate the association (i.e. socioeconomic status). Animal and human studies have been useful to define the anatomic substrates and physiologic processes that participate in the association, but, the evidence is preliminary in many areas (i.e gene x environmental interactions). Controlled studies have shown the strong impact that treatment of depression has on body weight and the large effect that has the correction of excess body weight on the depression-related symptoms. Practical implications of the depression-obesity duet include the training of the health providers to assess and treat these conditions in a concomitant manner, the need for translational medicine projects and the application the systems biology approach to fill the existing gaps of knowledge. (C) 2018 IMSS. Published by Elsevier Inc.
C1 Inst Nacl Nutr Salvador Zubiran, Unidad Invest Enfermedades Metab, Ciudad De Mexico, Mexico.
   Inst Tecnol & Estud Super Monterrey Tec Salud, Ciudad De Mexico, Mexico.
C3 Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran -
   Mexico; Tecnologico de Monterrey
RP Aguilar-Salinas, CA (corresponding author), Vasco de Quiroga 15, Ciudad De Mexico 14080, Mexico.
EM caguilarsalinas@yahoo.com
RI Salinas, Carlos/HSA-8329-2023
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NR 88
TC 29
Z9 30
U1 1
U2 15
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0188-4409
EI 1873-5487
J9 ARCH MED RES
JI Arch. Med. Res.
PD OCT
PY 2017
VL 48
IS 7
BP 582
EP 591
DI 10.1016/j.arcmed.2018.02.004
PG 10
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Research & Experimental Medicine
GA GC9ZW
UT WOS:000430158500002
PM 29478673
DA 2025-06-11
ER

PT J
AU Sánchez-Carro, Y
   de la Torre-Luque, A
   Leal-Leturia, I
   Salvat-Pujol, N
   Massaneda, C
   de Arriba-Arnau, A
   Urretavizcaya, M
   Pérez-Solà, V
   Toll, A
   Martínez-Ruiz, A
   Ferreirós-Martínez, R
   Pérez, S
   Sastre, J
   Alvarez, P
   Soria, V
   López-García, P
AF Sanchez-Carro, Yolanda
   de la Torre-Luque, Alejandro
   Leal-Leturia, Itziar
   Salvat-Pujol, Neus
   Massaneda, Clara
   de Arriba-Arnau, Aida
   Urretavizcaya, Mikel
   Perez-Sola, Victor
   Toll, Alba
   Martinez-Ruiz, Antonio
   Ferreiros-Martinez, Raquel
   Perez, Salvador
   Sastre, Juan
   Alvarez, Pilar
   Soria, Virginia
   Lopez-Garcia, Pilar
TI Importance of immunometabolic markers for the classification of patients
   with major depressive disorder using machine learning
SO PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
LA English
DT Article
DE Major depressive disorder; Inflammation; Oxidative stress; Metabolic
   syndrome; Lifestyle habits; Machine learning
ID NECROSIS-FACTOR-ALPHA; C-REACTIVE PROTEIN; PHYSICAL-ACTIVITY;
   LIPID-PEROXIDATION; TREATMENT RESPONSE; MENTAL-ILLNESS; EXERCISE;
   GLUTATHIONE; SMOKING; LIFE
AB Background: Although there is scientific evidence of the presence of immunometabolic alterations in major depression, not all patients present them. Recent studies point to the association between an inflammatory phenotype and certain clinical symptoms in patients with depression. The objective of our study was to classify major depression disorder patients using supervised learning algo-rithms or machine learning, based on immunometabolic and oxidative stress biomarkers and lifestyle habits.Methods: Taking into account a series of inflammatory and oxidative stress biomarkers (C-reactive protein (CRP), tumor necrosis factor (TNF), 4-hydroxynonenal (HNE) and glutathione), metabolic risk markers (blood pressure, waist circumference and glucose, triglyceride and cholesterol levels) and lifestyle habits of the participants (physical activity, smoking and alcohol consumption), a study was carried out using machine learning in a sample of 171 participants, 91 patients with depression (71.42% women, mean age = 50.64) and 80 healthy subjects (67.50% women, mean age = 49.12).The algorithm used was the support vector machine, performing cross validation, by which the subdivision of the sample in training (70%) and test (30%) was carried out in order to estimate the precision of the model. The prediction of belonging to the patient group (MDD patients versus control subjects), melancholic type (melancholic versus non-melancholic patients) or resistant depression group (treatment-resistant versus non -treatment-resistant) was based on the importance of each of the immunometabolic and lifestyle variables.Results: With the application of the algorithm, controls versus patients, such as patients with melancholic symptoms versus non-melancholic symptoms, and resistant versus non-resistant symptoms in the test phase were optimally classified.The variables that showed greater importance, according to the results of the area under the ROC curve, for the discrimination between healthy subjects and patients with depression were current alcohol consumption (AUC = 0.62), TNF-alpha levels (AUC = 0.61), glutathione redox status (AUC = 0.60) and the performance of both moderate (AUC = 0.59) and vigorous physical exercise (AUC = 0.58). On the other hand, the most important variables for classifying melancholic patients in relation to lifestyle habits were past (AUC = 0.65) and current (AUC = 0.60) tobacco habit, as well as walking routinely (AUC = 0.59) and in relation to immunometabolic markers were the levels of CRP (AUC = 0.62) and glucose (AUC = 0.58).In the analysis of the importance of the variables for the classification of treatment-resistant patients versus non-resistant patients, the systolic blood pressure (SBP) variable was shown to be the most relevant (AUC = 0.67). Other immunometabolic variables were also among the most important such as TNF-alpha (AUC = 0.65) and waist circumference (AUC = 0.64). In this case, sex (AUC = 0.59) was also relevant along with alcohol (AUC = 0.58) and tobacco (AUC = 0.56) consumption.Conclusions: The results obtained in our study show that it is possible to predict the diagnosis of depression and its clinical typology from immunometabolic markers and lifestyle habits, using machine learning techniques. The use of this type of methodology could facilitate the identification of patients at risk of presenting depression and could be very useful for managing clinical heterogeneity.
C1 [Sanchez-Carro, Yolanda; Leal-Leturia, Itziar; Lopez-Garcia, Pilar] Univ Autonoma Madrid UAM, Dept Psychiat, Madrid, Spain.
   [Sanchez-Carro, Yolanda; Leal-Leturia, Itziar; Lopez-Garcia, Pilar] Inst Invest Sanitaria Princesa IIS IP, Dept Psychiat, Madrid, Spain.
   [Sanchez-Carro, Yolanda; de la Torre-Luque, Alejandro; Leal-Leturia, Itziar; Urretavizcaya, Mikel; Perez-Sola, Victor; Soria, Virginia; Lopez-Garcia, Pilar] Carlos III Hlth Inst, Ctr Biomed Res Mental Hlth CIBERSAM, Madrid, Spain.
   [de la Torre-Luque, Alejandro] Univ Complutense Madrid, Dept Legal Med Psychiat & Pathol, Madrid, Spain.
   [Salvat-Pujol, Neus; Massaneda, Clara; de Arriba-Arnau, Aida; Urretavizcaya, Mikel; Soria, Virginia] Bellvitge Univ Hosp, Bellvitge Biomed Res Inst IDIBELL, Dept Psychiat, Neurosci Grp,Psychiat & Mental Hlth, Barcelona, Spain.
   [Salvat-Pujol, Neus] Corp Sanitaria Parc Tauli, Dept Mental Hlth, Sabadell, Spain.
   [Urretavizcaya, Mikel; Soria, Virginia] Univ Barcelona UB, Sch Med, Dept Clin Sci, Barcelona, Spain.
   [Perez-Sola, Victor] Univ Pompeu Fabra UPF, Barcelona, Spain.
   [Perez-Sola, Victor; Toll, Alba] Hosp Del Mar, Inst Neuropsiquiatria & Addic, Psychiat Dept, IMIM Hosp Del Mar,Med Res Inst, Barcelona, Spain.
   [Martinez-Ruiz, Antonio] Hosp Univ Santa Cristina, Unidad Invest, Inst Invest Sanitaria Princesa IIS IP, Madrid, Spain.
   [Ferreiros-Martinez, Raquel] Hosp Univ Princesa, Serv Clin Anal, Inst Invest Sanitaria Princesa IIS IP, Madrid, Spain.
   [Perez, Salvador; Sastre, Juan] Univ Valencia, Fac Pharm, Dept Physiol, Valencia, Spain.
   [Alvarez, Pilar] IMIM Hosp Del Mar, Psychiat Dept, Inst Neuropsiquiatria & Addic, Ctr Forum,Med Res Inst, Barcelona, Spain.
C3 CIBER - Centro de Investigacion Biomedica en Red; CIBERSAM; Complutense
   University of Madrid; University of Barcelona; Institut d'Investigacio
   Biomedica de Bellvitge (IDIBELL); Bellvitge University Hospital;
   Autonomous University of Barcelona; Parc Tauli Hospital Universitari;
   University of Barcelona; Pompeu Fabra University; Hospital del Mar
   Research Institute; Hospital del Mar; Hospital de La Princesa;
   University of Valencia; Hospital del Mar Research Institute; Hospital
   del Mar
RP López-García, P (corresponding author), Carlos III Hlth Inst, Ctr Biomed Res Mental Hlth CIBERSAM, Madrid, Spain.; López-García, P (corresponding author), Univ Autonoma Madrid, Sch Med, Dept Psychiat, 4 Arzobispo Morcillo St, Madrid 28029, Spain.
RI SASTRE, JUAN/AAB-2344-2019; Sanchez Carro, Yolanda/AAC-9898-2022;
   Lopez-Garcia, Pilar/F-5934-2013; Pérez, Salvador/N-5943-2014; Pérez
   Sola, Víctor/KBA-2879-2024; Alvarez, Pilar/JAC-0258-2023; de la
   Torre-Luque, Alejandro/AAJ-3508-2020; Toll, Alba/O-1512-2015;
   Martinez-Ruiz, Antonio/A-5672-2009
OI Alvarez, Pilar/0000-0002-6648-3493; Sanchez,
   Yolanda/0000-0002-8644-9436; Toll, Alba/0000-0003-2399-5250; Perez Sola,
   Victor/0000-0002-5825-2337; Massaneda-Tuneu, Clara/0000-0003-4385-0518;
   Martinez-Ruiz, Antonio/0000-0001-5394-9824; Soria,
   Virginia/0000-0001-6412-6831
FU Carlos III Health Institute through the Ministry of Science, Innovation
   and Universities [PI15/00662, PI15/0039, PI15/00204, PI19/01040];
   European Regional Development Fund (ERDF) "A way to build Europe";
   CIBERSAM; Catalan Agency for the Management of University and Research
   Grants [AGAUR 2017 SGR 1247]; Biobank HUB-ICO-IDIBELL, integrated in the
   Spanish Biobank Network; Instituto de Salud Carlos III [PT17/0015/0024,
   INT21/00055]; Xarxa Bancs de Tumors de Catalunya - Pla Director
   d'Oncologia de Catalunya (XBTC); Universidad Autonoma de Madrid [FPI
   2016/17]
FX This study was supported in part by grants from the Carlos III Health
   Institute through the Ministry of Science, Innovation and Universities
   (PI15/00662, PI15/0039, PI15/00204, PI19/01040), co-funded by the
   European Regional Development Fund (ERDF) "A way to build Europe",
   CIBERSAM, and the Catalan Agency for the Management of University and
   Research Grants (AGAUR 2017 SGR 1247). We also thank CERCA
   Programme/Generalitat de Catalunya for institutional support. Work
   partially supported by Biobank HUB-ICO-IDIBELL, integrated in the
   Spanish Biobank Network and funded by Instituto de Salud Carlos III
   (PT17/0015/0024) and by Xarxa Bancs de Tumors de Catalunya sponsored by
   Pla Director d'Oncologia de Catalunya (XBTC). The funders had no role in
   the study design, data collection and analysis, decision to publish, or
   preparation of the manuscript. YSC work is supported by the FPI
   predoctoral grant (FPI 2016/17) from Universidad Autonoma de Madrid. VS
   received an Intensification of the Research Activity Grant from the
   Instituto de Salud Carlos III (INT21/00055) during 2022.
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NR 88
TC 11
Z9 11
U1 0
U2 15
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0278-5846
EI 1878-4216
J9 PROG NEURO-PSYCHOPH
JI Prog. Neuro-Psychopharmacol. Biol. Psychiatry
PD MAR 8
PY 2023
VL 121
AR 110674
DI 10.1016/j.pnpbp.2022.110674
EA NOV 2022
PG 10
WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA 7B8NL
UT WOS:000899384000003
PM 36332700
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Contreras, C
   González-García, I
   Martínez-Sánchez, N
   Seoane-Collazo, P
   Jacas, J
   Morgan, DA
   Serra, D
   Gallego, R
   Gonzalez, F
   Casals, N
   Nogueiras, R
   Rahmouni, K
   Diéguez, C
   López, M
AF Contreras, Cristina
   Gonzalez-Garcia, Ismael
   Martinez-Sanchez, Noelia
   Seoane-Collazo, Patricia
   Jacas, Jordi
   Morgan, Donald A.
   Serra, Dolors
   Gallego, Rosalia
   Gonzalez, Francisco
   Casals, Nuria
   Nogueiras, Ruben
   Rahmouni, Kamal
   Dieguez, Carlos
   Lopez, Miguel
TI Central Ceramide-Induced Hypothalamic Lipotoxicity and ER Stress
   Regulate Energy Balance
SO CELL REPORTS
LA English
DT Article
ID ENDOPLASMIC-RETICULUM STRESS; BROWN ADIPOSE-TISSUE; UNFOLDED PROTEIN
   RESPONSE; INSULIN-RESISTANCE; METABOLIC SYNDROME; LEPTIN RESISTANCE;
   HEPATIC STEATOSIS; OBESITY; KINASE; NEURONS
AB Hypothalamic endoplasmic reticulum (ER) stress is a key mechanism leading to obesity. Here, we demonstrate that ceramides induce lipotoxicity and hypothalamic ER stress, leading to sympathetic inhibition, reduced brown adipose tissue (BAT) thermogenesis, and weight gain. Genetic overexpression of the chaperone GRP78/BiP (glucose-regulated protein 78 kDa/binding immunoglobulin protein) in the ventromedial nucleus of the hypothalamus (VMH) abolishes ceramide action by reducing hypothalamic ER stress and increasing BAT thermogenesis, which leads to weight loss and improved glucose homeostasis. The pathophysiological relevance of this mechanism is demonstrated in obese Zucker rats, which show increased hypothalamic ceramide levels and ER stress. Overexpression of GRP78 in the VMH of these animals reduced body weight by increasing BAT thermogenesis as well as decreasing leptin and insulin resistance and hepatic steatosis. Overall, these data identify a triangulated signaling network involving central ceramides, hypothalamic lipotoxicity/ER stress, and BAT thermogenesis as a pathophysiological mechanism of obesity.
C1 [Contreras, Cristina; Gonzalez-Garcia, Ismael; Martinez-Sanchez, Noelia; Seoane-Collazo, Patricia; Nogueiras, Ruben; Dieguez, Carlos; Lopez, Miguel] Univ Santiago de Compostela, Inst Invest Sanitaria, Dept Physiol, CIMUS, Santiago De Compostela 15782, Spain.
   [Contreras, Cristina; Gonzalez-Garcia, Ismael; Martinez-Sanchez, Noelia; Seoane-Collazo, Patricia; Jacas, Jordi; Serra, Dolors; Casals, Nuria; Nogueiras, Ruben; Dieguez, Carlos; Lopez, Miguel] CIBER Fisiopatol Obesidad & Nutr CIBERobn, Santiago De Compostela 15706, Spain.
   [Jacas, Jordi; Casals, Nuria] Univ Int Catalunya, Fac Med & Hlth Sci, Dept Basic Sci, Barcelona 08195, Spain.
   [Morgan, Donald A.; Rahmouni, Kamal] Univ Iowa, Dept Pharmacol, Iowa City, IA 52242 USA.
   [Serra, Dolors] Univ Barcelona, Inst Biomed IBUB, Sch Pharm, Dept Biochem & Mol Biol, E-08028 Barcelona, Spain.
   [Gallego, Rosalia] Univ Santiago de Compostela, Sch Med, Dept Morphol Sci, Santiago De Compostela 15782, Spain.
   [Gonzalez, Francisco] Univ Santiago de Compostela, Inst Invest Sanitaria, Dept Surg, CIMUS, Santiago De Compostela 15782, Spain.
   [Gonzalez, Francisco] Complejo Hospitalario Univ Santiago de Compostela, Serv Ophthalmol, Santiago De Compostela 15706, Spain.
   [Rahmouni, Kamal] Univ Iowa, Dept Internal Med, Iowa City, IA 52242 USA.
C3 Universidade de Santiago de Compostela; CIBER - Centro de Investigacion
   Biomedica en Red; CIBEROBN; Universitat Internacional de Catalunya
   (UIC); University of Iowa; University of Barcelona; Universidade de
   Santiago de Compostela; Universidade de Santiago de Compostela; Complexo
   Hospitalario Universitario de Santiago de Compostela; University of Iowa
RP López, M (corresponding author), Univ Santiago de Compostela, Inst Invest Sanitaria, Dept Physiol, CIMUS, Santiago De Compostela 15782, Spain.
EM m.lopez@usc.es
RI Rahmouni, Kamal/Y-1788-2019; González-García, Ismael/ABG-3122-2020;
   Nogueiras, Ruben/AAS-9427-2021; Biendicho, Jordi/H-8282-2015;
   Seoane-Collazo, Patricia/AAB-8404-2019; Contreras, Cristina/N-7257-2019;
   Serra, Dolors/L-3657-2014; Casals, Nuria/L-3378-2014; Gonzalez,
   Francisco/N-4135-2014; Lopez, Miguel/ABF-4844-2021; Morgan,
   Donald/L-6907-2013
OI Serra, Dolors/0000-0002-4936-4206; Contreras,
   Cristina/0000-0002-7015-7922; Gonzalez-Garcia,
   Ismael/0000-0002-5545-5841; Seoane-Collazo,
   Patricia/0000-0002-7102-7935; Martinez-Sanchez,
   Noelia/0000-0003-4580-8196; Casals, Nuria/0000-0002-6719-4300;
   Nogueiras, Ruben/0000-0002-9976-9930; Rosalia,
   Gallego/0000-0002-6015-4680; Rahmouni, Kamal/0000-0001-5136-6748;
   Gonzalez, Francisco/0000-0002-1461-5474; dieguez,
   carlos/0000-0002-0919-4337; Lopez, Miguel/0000-0002-7823-1648; Morgan,
   Donald/0000-0003-3167-1643
FU European Community's Seventh Framework Programme (FP7) [281854];
   ObERStress European Research Council Project [245009]; Neurofast
   project; Xunta de Galicia [10PXIB208126PR, EM 2012/039, 2012-CP069,
   2012-CP070]; Instituto de Salud Carlos III (ISCIII) [PI12/01814];
   MINECO; FEDER Program of EU [BFU-2010-14968, SAF2011-30520-C02-01,
   BFU2012-35255, SAF2011-30520-C02-02, BFU2011-29102]; NIH [HL084207];
   Ministerio de Educacion, Cultura y Deporte [FPU12/01827]; National Heart
   Lung and Blood Institute [P01HL084207] Funding Source: NIH RePORTER
FX The research leading to these results has received funding from the
   European Community's Seventh Framework Programme (FP7/2007-2013) under
   grant agreement no. 281854, the ObERStress European Research Council
   Project (M. L.), and 245009, the Neurofast project (R.N., C. D., and M.
   L.), Xunta de Galicia (F. G., 10PXIB208126PR; R.N., EM 2012/039 and
   2012-CP069; M. L., 2012-CP070), Instituto de Salud Carlos III (ISCIII;
   M. L., PI12/01814), MINECO cofunded by the FEDER Program of EU (F. G.,
   BFU-2010-14968; D. S., SAF2011-30520-C02-01; R.N., BFU2012-35255; N. C.,
   SAF2011-30520-C02-02; C. D., BFU2011-29102), and the NIH (K. R.:
   HL084207). I. G.-G. is a recipient of a fellowship from Ministerio de
   Educacion, Cultura y Deporte (FPU12/01827). CIBER de Fisiopatologia de
   la Obesidad y Nutricion is an initiative of ISCIII. The funders had no
   role in study design, data collection and analysis, decision to publish,
   or preparation of the manuscript.
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NR 62
TC 193
Z9 207
U1 0
U2 28
PU CELL PRESS
PI CAMBRIDGE
PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA
SN 2211-1247
J9 CELL REP
JI Cell Reports
PD OCT 9
PY 2014
VL 9
IS 1
BP 366
EP 377
DI 10.1016/j.celrep.2014.08.057
PG 12
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA AS7YP
UT WOS:000344468100031
PM 25284795
OA Green Accepted, gold, Green Published
DA 2025-06-11
ER

PT J
AU Jia, GH
   Sowers, JR
AF Jia, Guanghong
   Sowers, James R.
TI Autophagy: A housekeeper in cardiorenal metabolic health and disease
SO BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
LA English
DT Review
DE Autophagy; Cardiorenal metabolic syndrome; Insulin resistance; Obesity;
   Endoplasmic reticulum stress; Reactive oxygen species
ID ACTIVATED PROTEIN-KINASE; PANCREATIC BETA-CELLS; DIET-INDUCED OBESITY;
   INSULIN-RESISTANCE; DIABETES-MELLITUS; CARDIAC AUTOPHAGY;
   VASCULAR-DISEASE; DYSFUNCTION; AMPK; STRESS
AB Autophagy, literally translated means self-eating, is a primary degradative pathway and plays an important role in the regulation of cellular homeostasis through elimination of aggregated proteins, damaged organelles, and intracellular pathogens. Autophagy has been classified into microautophagy, macroautophagy, and chaperonemediated autophagy, depending on the choice of the pathway by which the cellular material is delivered to lysosomes. Dysregulation of autophagy may contribute to the development of cardiorenal metabolic syndrome (CRS), including insulin resistance, obesity, hypertension, maladaptive immune modulation, and associated cardiac and renal disease. Clarifying the pathways and mechanisms of autophagy under normal conditions is essential to understanding its dysregulation in the development of CRS. Here, we highlight a recent surge in autophagy research, such as the cellular quality control through the disposal and recycling of cellular components, and summarize our contemporary understanding of molecular mechanisms of autophagy in diverse organ or tissues involved in the pathogenesis of CRS. This article is part of a Special Issue entitled: Autophagy and protein quality control in cardiometabolic diseases. (C) 2014 Published by Elsevier B.V.
C1 [Jia, Guanghong; Sowers, James R.] Univ Missouri, Sch Med, Diabet Cardiovasc Ctr, Div Endocrinol, Columbia, MO USA.
   [Jia, Guanghong; Sowers, James R.] Univ Missouri, Sch Med, Diabet Cardiovasc Ctr, Div Diabet, Columbia, MO USA.
   [Jia, Guanghong; Sowers, James R.] Univ Missouri, Sch Med, Diabet Cardiovasc Ctr, Div Hypertens, Columbia, MO USA.
   [Jia, Guanghong; Sowers, James R.] Univ Missouri, Sch Med, Diabet Cardiovasc Ctr, Div Metab, Columbia, MO USA.
   [Sowers, James R.] Univ Missouri, Sch Med, Dept Med Pharmacol, Columbia, MO USA.
   [Sowers, James R.] Univ Missouri, Sch Med, Dept Physiol, Columbia, MO 65212 USA.
   [Jia, Guanghong; Sowers, James R.] Univ Missouri, Sch Med, Harry S Truman Mem Vet Hosp, Columbia, MO USA.
C3 University of Missouri System; University of Missouri Columbia;
   University of Missouri System; University of Missouri Columbia;
   University of Missouri System; University of Missouri Columbia;
   University of Missouri System; University of Missouri Columbia;
   University of Missouri System; University of Missouri Columbia;
   University of Missouri System; University of Missouri Columbia;
   University of Missouri System; University of Missouri Columbia; US
   Department of Veterans Affairs; Veterans Health Administration (VHA);
   Harry S. Truman Memorial Veterans' Hospital
RP Sowers, JR (corresponding author), Univ Missouri, D109 Diabet Ctr HSC,One Hosp Dr, Columbia, MO 65212 USA.
EM sowersj@health.missouri.edu
FU NIH [R01 HL73101-01A, R01 HL107910-01]; Veterans Affairs Merit System
   [0018]
FX The authors would like to thank Brenda Hunter for her editorial
   assistance. This research was supported by NIH (R01 HL73101-01A, R01
   HL107910-01) and the Veterans Affairs Merit System (0018) for JRS.
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NR 64
TC 45
Z9 53
U1 0
U2 27
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0925-4439
EI 0006-3002
J9 BBA-MOL BASIS DIS
JI Biochim. Biophys. Acta-Mol. Basis Dis.
PD FEB
PY 2015
VL 1852
IS 2
SI SI
BP 219
EP 224
DI 10.1016/j.bbadis.2014.06.025
PG 6
WC Biochemistry & Molecular Biology; Biophysics; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Cell Biology
GA CA5QR
UT WOS:000348963400005
PM 24984281
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Suzuki, I
   Yamauchi, T
   Onuma, M
   Nozaki, S
AF Suzuki, Iwao
   Yamauchi, Takayuki
   Onuma, Masahiro
   Nozaki, Shigeo
TI ALLOPURINOL, AN INHIBITOR OF URIC ACID SYNTHESIS - CAN IT BE USED FOR
   THE TREATMENT OF METABOLIC SYNDROME AND RELATED DISORDERS?
SO DRUGS OF TODAY
LA English
DT Review
ID FATTY LIVER-DISEASE; XANTHINE OXIDOREDUCTASE ACTIVITY; IMPROVES
   ENDOTHELIAL FUNCTION; CHRONIC-KIDNEY-DISEASE; PANCREATIC STELLATE CELL;
   STEVENS-JOHNSON-SYNDROME; TUMOR LYSIS SYNDROME; OXIDATIVE STRESS;
   RISK-FACTORS; GLOMERULAR HYPERTENSION
AB Allopurinol is an inhibitor of xanthine oxidoreductase (XOR) and inhibits the generation of uric acid (UA) as the final product of purine catabolism, as well as the resulting generation of superoxide (O-2(-)), in humans. Elevation of the serum UA (SUA) level, referred to as hyperuricemia (HU), eventually leads to gout and allopurinol has been used for the treatment of HU and gout. Studies have revealed the role of elevated SUA levels and the associated oxidative stress (OS) in a broad spectrum of pathological conditions and it is anticipated that these findings would also expand the use of allopurinol as a therapeutic drug. This article presents a review of reports, mainly of recent studies, on the efficacy of allopurinol in various diseases and explores novel potential uses of the drug. Important novel and potential uses of great interest include metabolic syndrome (MetS) and related disorders, chronic kidney disease (CKD), nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH). Ischemia-reperfusion injury and mucositis, encountered as adverse effects of cancer treatment, have also been under investigation as potential targets for allopurinol.
C1 [Suzuki, Iwao; Yamauchi, Takayuki; Onuma, Masahiro; Nozaki, Shigeo] GlaxoSmithKline KK, Gen Pharma Franchise, Shibuya Ku, Tokyo 1518566, Japan.
C3 GlaxoSmithKline; GlaxoSmithKline Japan
RP Suzuki, I (corresponding author), GlaxoSmithKline KK, Gen Pharma Franchise, Shibuya Ku, 6-15 Sendagaya,4 Chome, Tokyo 1518566, Japan.
EM Iwao.Suzuki@gsk.com
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NR 151
TC 33
Z9 36
U1 1
U2 16
PU PROUS SCIENCE, SAU-THOMSON REUTERS
PI BARCELONA
PA 398 PROVENCA, 08025 BARCELONA, SPAIN
SN 1699-3993
EI 1699-4019
J9 DRUG TODAY
JI Drugs Today
PD MAY
PY 2009
VL 45
IS 5
BP 363
EP 378
DI 10.1358/dot.2009.45.5.1377598
PG 16
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 482VE
UT WOS:000268916300004
PM 19584965
DA 2025-06-11
ER

PT J
AU Jiang, QK
   Maresch, CC
   Petry, SF
   Paradowska-Dogan, A
   Bhushan, S
   Chang, YS
   Wrenzycki, C
   Schuppe, HC
   Houska, P
   Hartmann, MF
   Wudy, SA
   Shi, LB
   Linn, T
AF Jiang, Qingkui
   Maresch, Constanze C.
   Petry, Sebastian Friedrich
   Paradowska-Dogan, Agnieszka
   Bhushan, Sudhanshu
   Chang, Yongsheng
   Wrenzycki, Christine
   Schuppe, Hans-Christian
   Houska, Petr
   Hartmann, Michaela F.
   Wudy, Stefan A.
   Shi, Lanbo
   Linn, Thomas
TI Elevated CCL2 causes Leydig cell malfunction in metabolic syndrome
SO JCI INSIGHT
LA English
DT Article
ID MONOCYTE CHEMOATTRACTANT PROTEIN-1; TUMOR-NECROSIS-FACTOR; ADULT-RAT
   TESTIS; BODY-MASS INDEX; OXIDATIVE STRESS; LEPTIN-RECEPTOR;
   ADIPOSE-TISSUE; SEMEN QUALITY; FACTOR-ALPHA; OBESITY
AB Metabolic syndrome (MetS), which is associated with chronic inflammation, predisposes males to hypogonadism and subfertility. The underlying mechanism of these pathologies remains poorly understood. Homozygous leptin-resistant obese db/db mice are characterized by small testes, low testicular testosterone, and a reduced number of Leydig cells. Here we report that IL-1 beta, CCL2 (also known as MCP-1), and corticosterone concentrations were increased in the testes of db/db mice relative to those in WT controls. Cultured marine and human Leydig cells responded to cytokine stress with increased CCL2 release and apoptotic signals. Chemical inhibition of CCL2 rescued Leydig cell function in vitro and in db/db mice. Consistently, we found that CCL2-deficient mice fed with a high-energy diet were protected from testicular dysfunction compared with similarly fed WT mice. Finally, a cohort of infertile men with a history of MetS showed that reduction of CCL2 plasma levels could be achieved by weight loss and was clearly associated with recovery from hypogonadism. Taken together, we conclude that CCL2-mediated chronic inflammation is, to a large extent, responsible for the subfertility in MetS by causing damage to Leydig cells.
C1 [Jiang, Qingkui; Maresch, Constanze C.; Petry, Sebastian Friedrich; Houska, Petr; Linn, Thomas] Justus Liebig Univ JLU, Ctr Internal Med, Clin Res Unit, Giessen, Germany.
   [Paradowska-Dogan, Agnieszka] Univ Clin Bonn, Dept Gynecol Endocrinol & Reprod Med, Bonn, Germany.
   [Bhushan, Sudhanshu] JLU, Dept Reprod Biol, Inst Anat & Cell Biol, Giessen, Germany.
   [Chang, Yongsheng] Tianjin Med Univ, Dept Physiol & Pathophysiol, Tianjin Key Lab Cellular & Mol Immunol, Key Lab Immune Microenvironm & Dis,Minist Educ, Tianjin, Peoples R China.
   [Wrenzycki, Christine] JLU, Clin Vet Obstet Gynecol & Androl, Dept Mol Reprod Med, Giessen, Germany.
   [Schuppe, Hans-Christian] JLU, Dept Urol Pediat Urol & Androl, Giessen, Germany.
   [Houska, Petr] Karolinska Univ Hosp, ANOVA, Stockholm, Sweden.
   [Houska, Petr] Karolinska Inst, Stockholm, Sweden.
   [Hartmann, Michaela F.; Wudy, Stefan A.] JLU, Div Pediat Endocrinol & Diabetol, Steroid Res & Mass Spectrometry Unit, Ctr Child & Adolescent Med, Giessen, Germany.
   [Jiang, Qingkui; Shi, Lanbo] Rutgers State Univ, New Jersey Med Sch, Publ Hlth Res Inst, Rutgers Biomed & Hlth Sci, Newark, NJ USA.
C3 University of Bonn; Justus Liebig University Giessen; Tianjin Medical
   University; Ministry of Education - China; Justus Liebig University
   Giessen; Justus Liebig University Giessen; Karolinska Institutet;
   Karolinska University Hospital; Karolinska Institutet; Justus Liebig
   University Giessen; Rutgers University System; Rutgers University New
   Brunswick; Rutgers University Biomedical & Health Sciences; Rutgers
   University Newark
RP Linn, T (corresponding author), Justus Liebig Univ, Ctr Internal Med, Clin Res Unit, Klin Str 33, Giessen, Germany.
RI Wudy, Stefan/ABC-7173-2020; Petry, Sebastian/JCO-7283-2023; Jiang,
   Qingkui/AAE-1753-2022
OI Houska, Petr/0000-0003-2840-1298; Petry, Sebastian
   Friedrich/0000-0002-3496-9894; Hartmann, Michaela/0000-0001-7232-9532
FU Deutsche Forschungsgemeinschaft [DFG LI 353/17-1]; Bundesministerium fur
   Bildung und Forschung [01DL13015]
FX The authors thank Gundula Hertl, Birte Hussmann, Doris Erb, Tania Bloch,
   Kerstin Wilhelm, Franziska Kotarski, Barbara Frohlich, Ming Wang, Lei
   Zhang, and Sanjay Tyagi for expert advice and technical assistance. This
   work was supported by grants from Deutsche Forschungsgemeinschaft to TL
   (DFG LI 353/17-1) and Bundesministerium fur Bildung und Forschung to TL
   (01DL13015). The funders had no role in study design, data collection
   and analysis, decision to publish, or preparation of the manuscript. We
   acknowledge Life Science Editors and Ryan Dikdan for editing assistance.
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NR 90
TC 17
Z9 18
U1 0
U2 7
PU AMER SOC CLINICAL INVESTIGATION INC
PI ANN ARBOR
PA 2015 MANCHESTER RD, ANN ARBOR, MI 48104 USA
EI 2379-3708
J9 JCI INSIGHT
JI JCI Insight
PD NOV 5
PY 2020
VL 5
IS 21
AR e134882
DI 10.1172/jci.insight.134882
PG 20
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA OP9TN
UT WOS:000588434700003
PM 33148888
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Calligaris, SD
   Conget, P
AF Calligaris, Sebastian D.
   Conget, Paulette
TI Intravenous administration of bone marrow-derived multipotent
   mesenchymal stromal cells has a neutral effect on obesity-induced
   diabetic cardiomyopathy
SO BIOLOGICAL RESEARCH
LA English
DT Article
DE Obesity; metabolic syndrome; diabetic cardiomyopathy; multipotent
   mesenchymal stromal cells; cardiac function; dobutamine
ID PREVENTS; THERAPY; MICE
AB Obesity is a major global health issue. Obese patients develop metabolic syndrome, which is a cluster of clinical features characterized by insulin resistance and dyslipidemia. Its cardiac manifestation, diabetic cardiomyopathy, leads to heart failure.
   Bone marrow-derived multipotent mesenchymal stromal cells, also referred to as mesenchymal stem cells (MSC) are envisioned as a therapeutic tool not only for cardiovascular diseases but also for other degenerative conditions.
   Our aim was to evaluate whether the intravenous administration of MSC modifies cardiac dysfunction in obese mice. To this end, C57BL /6 mice were fed a regular (normal) or high-fat diet (obese). Obese animals received the vehicle (obese), a single dose (obese + 1x MSC) or three doses (obese + 3x MSC) of 0.5x10(6) syngeneic MSC. Two to three months following MSC administration, cardiac function was assessed by cardiac catheterization, at basal condition and after a pharmacological stress.
   Compared to normal mice, obese mice presented hyperglycemia, hyperinsulinemia, hypercholesterolemia and cardiac dysfunction after stress condition. Exogenous MSC neither improved nor impaired this cardiac dysfunction.
   Thus, intravenous administration of MSC has neutral effect on obesity-induced diabetic cardiomyopathy.
C1 [Calligaris, Sebastian D.; Conget, Paulette] Univ Desarrollo, Inst Ciencias, Fac Med, Clin Alemana, Santiago, Chile.
C3 Universidad del Desarrollo; Clinica Alemana
RP Calligaris, SD (corresponding author), Univ Desarrollo, Inst Ciencias, Fac Med, Clin Alemana, Av Las Condes 12-438, Santiago, Chile.
EM scalligaris@udd.cl
OI Conget, Paulette/0000-0002-2530-7936; Calligaris Caprioglio, Sebastian
   Dante/0000-0002-9296-6739
FU FONDECYT [11090114]
FX This work was supported by FONDECYT grant No11090114 to SDC.
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NR 27
TC 10
Z9 10
U1 0
U2 3
PU SOC BIOLGIA CHILE
PI SANTIAGO
PA CASILLA 16164, SANTIAGO 9, CHILE
SN 0716-9760
EI 0717-6287
J9 BIOL RES
JI Biol. Res.
PY 2013
VL 46
IS 3
BP 251
EP 255
DI 10.4067/S0716-97602013000300005
PG 5
WC Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics
GA 241YR
UT WOS:000326205100005
PM 24346072
OA gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Zhang, L
   Wu, YL
   Jia, ZH
   Zhang, Y
   Shen, HY
   Wang, XL
AF Zhang, Lin
   Wu, Yiling
   Jia, Zhenhua
   Zhang, Yun
   Shen, Hu Ying
   Wang, Xing Li
TI Protective effects of a compound herbal extract (Tong Xin Luo) on free
   fatty acid induced endothelial injury: Implications of antioxidant
   system
SO BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Article
ID ACTIVATED PROTEIN-KINASE; CARDIOVASCULAR RISK-FACTOR; NITRIC-OXIDE
   PRODUCTION; METABOLIC SYNDROME; INSULIN-RESISTANCE; OXIDATIVE STRESS;
   CELLS; APOPTOSIS; DISEASE; THIOREDOXIN
AB Background: Tong-Xin-Luo (TXL) - a mixture of herbal extracts, has been used in Chinese medicine with established therapeutic efficacy in patients with coronary artery disease.
   Methods: We investigated the protective role of TXL extracts on endothelial cells injured by a known risk factor - palmitic acid (PA), which is elevated in metabolic syndrome and associated with cardiovascular complications. Human aortic endothelial cells ( HAECs) were preconditioned with TXL extracts before exposed to PA for 24 hours.
   Results: We found that PA (0.5 mM) exposure induced 73% apoptosis in endothelial cells. However, when HAECs were preconditioned with ethanol extracted TXL ( 100 mu g/ml), PA induced only 7% of the endothelial cells into apoptosis. Using antibody-based protein microarray, we found that TXL attenuated PA-induced activation of p38-MAPK stress pathway. To investigate the mechanisms involved in TXL's protective effects, we found that TXL reduced PA-induced intracellular oxidative stress. Through AMPK pathway, TXL restored the intracellular antioxidant system, which was depressed by the PA treatment, with an increased expression of thioredoxin and a decreased expression of the thioredoxin interacting protein.
   Conclusion: In summary, our study demonstrates that TXL protects endothelial cells from PA-induced injury. This protection is likely mediated by boosting intracellular antioxidant capacity through AMPK pathway, which may account for the therapeutic efficacy in TXL-mediated cardiovascular protection.
C1 [Wu, Yiling; Jia, Zhenhua] Res Inst Integrated Tradit Chinese Med & Western, Hebei, Peoples R China.
   [Zhang, Lin; Shen, Hu Ying; Wang, Xing Li] Texas Heart Inst, Baylor Coll Med, Michael E DeBakey Dept Surg, Houston, TX 77025 USA.
   [Zhang, Yun] Shandong Univ, Qilu Hosp, Key Lab Cardiovasc Remodeling & Funct Res, Chinese Minist Educ, Jinan 250100, Peoples R China.
   [Zhang, Yun] Shandong Univ, Qilu Hosp, Key Lab Cardiovasc Remodeling & Funct Res, Chinese Minist Hlth, Jinan 250100, Peoples R China.
C3 Texas Heart Institute; Baylor College of Medicine; Shandong University;
   Ministry of Education - China; Shandong University
RP Wu, YL (corresponding author), Res Inst Integrated Tradit Chinese Med & Western, Hebei, Peoples R China.
EM linz@bcm.edu; jiatcm@163.com; jiatcm@163.com; yunzhang@sdu.edu.cn;
   hyshen@bcm.edu; xlwang@bcm.edu
RI wang, xingli/MHR-1399-2025; WU, Yuying/ISB-0204-2023
FU AHA [0565134Y, 0730190N]; NBR 973 Program of China [2005CB523301]; ICST
   [2006DFB32460]; American Heart Association (AHA) [0565134Y, 0730190N]
   Funding Source: American Heart Association (AHA)
FX This project was supported by AHA 0565134Y & 0730190N; NBR 973 Program
   of China, No. 2005CB523301, and ICST, NO. 2006DFB32460).
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NR 48
TC 19
Z9 23
U1 0
U2 5
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1472-6882
J9 BMC COMPLEM ALTERN M
JI BMC Complement. Altern. Med.
PD JUL 14
PY 2008
VL 8
AR 39
DI 10.1186/1472-6882-8-39
PG 10
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA 398QK
UT WOS:000262746400001
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Zhang, J
   Sun, RY
   Cai, Y
   Peng, B
   Yang, X
   Gao, KM
AF Zhang, Jian
   Sun, Rongyi
   Cai, Yang
   Peng, Bo
   Yang, Xi
   Gao, Keming
TI Efficacy and Safety of Antidiabetic Agents for Major Depressive Disorder
   and Bipolar Depression: A Meta-Analysis of Randomized, Double-Blind,
   Placebo-Controlled Trials
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Article
DE bipolar disorder; depression; antidiabetic; meta-analysis
ID TRANSCRANIAL MAGNETIC STIMULATION; STAR-ASTERISK-D; PIOGLITAZONE
   ADJUNCTIVE THERAPY; TYPE-2 DIABETES-MELLITUS; INSULIN-RESISTANCE;
   2ND-GENERATION ANTIPSYCHOTICS; COGNITIVE DYSFUNCTION; INTRANASAL
   INSULIN; METABOLIC SYNDROME; RESIDUAL SYMPTOMS
AB Background: This meta-analysis aimed to determine the efficacy and safety of antidiabetic agents in the treatment of major depressive disorder and bipolar depression. Methods: Randomized controlled trials (RCTs) of antidiabetic agents in major depressive disorder or bipolar depression were searched in three electronic databases and three clinical trial registry websites from their inception up to October 2023. The differences in changes in the depression rating scale scores from baseline to endpoint or pre-defined sessions, response rate, remission rate, rate of side effects and dropout rate between antidiabetic agents and placebo were meta-analyzed. Results: Six RCTs involving 399 participants were included in the final meta-analysis, which did not find that antidiabetics outperformed the placebo in reducing depressive symptoms. The standardized mean difference (SMD) in the depression scores from baseline to endpoint was 0.25 (95% CI -0.1, 0.61). However, a subgroup analysis found a significant difference between antidiabetics and placebos in reducing depressive symptoms in Middle Eastern populations, with an SMD of 0.89 (95% CI 0.44, 1.34). Conclusions: The current meta-analysis does not support the efficacy of antidiabetics being superior to the placebo in the treatment of unipolar and bipolar depression. However, a subgroup analysis indicates that patients from the Middle East may benefit from adding an antidiabetic medication to their ongoing medication(s) for their depression. Larger studies with good-quality study designs are warranted.
C1 [Zhang, Jian; Peng, Bo; Yang, Xi] Shenzhen Kangning Hosp, Shenzhen Mental Hlth Ctr, Shenzhen 518020, Peoples R China.
   [Zhang, Jian; Gao, Keming] Univ Hosp Cleveland Med Ctr, Dept Psychiat, Mood Disorders Program, 10524 Euclid Ave,12th Floor, Cleveland, OH 44106 USA.
   [Sun, Rongyi; Cai, Yang; Gao, Keming] Case Western Reserve Univ, Sch Med, Dept Psychiat, Cleveland, OH 44106 USA.
C3 Shenzhen Institute of Mental Health & Shenzhen Kangning Hospital;
   University Hospitals of Cleveland; University System of Ohio; Case
   Western Reserve University
RP Gao, KM (corresponding author), Univ Hosp Cleveland Med Ctr, Dept Psychiat, Mood Disorders Program, 10524 Euclid Ave,12th Floor, Cleveland, OH 44106 USA.; Gao, KM (corresponding author), Case Western Reserve Univ, Sch Med, Dept Psychiat, Cleveland, OH 44106 USA.
EM zhjjjjjj@126.com; keming.gao@uhhospitals.org
FU Shenzhen Key Medical Discipline Construction Fund
FX No Statement Available
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   ,, 2008, The global burden of disease: 2004 update
NR 119
TC 4
Z9 4
U1 0
U2 4
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD FEB
PY 2024
VL 13
IS 4
AR 1172
DI 10.3390/jcm13041172
PG 24
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA JI3C6
UT WOS:001172487200001
PM 38398483
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Kwon, J
   Kim, DY
   Cho, KJ
   Hashimoto, M
   Matsuoka, K
   Kamijo, T
   Wang, Z
   Karnup, S
   Robertson, AM
   Tyagi, P
   Yoshimura, N
AF Kwon, Joonbeom
   Kim, Duk Yoon
   Cho, Kang Jun
   Hashimoto, Mamoru
   Matsuoka, Kanako
   Kamijo, Tadanobu
   Wang, Zhou
   Karnup, Sergei
   Robertson, Anne M.
   Tyagi, Pradeep
   Yoshimura, Naoki
TI Pathophysiology of Overactive Bladder and Pharmacologic Treatments
   Including j33-Adrenoceptor Agonists -Basic Research Perspectives-
SO INTERNATIONAL NEUROUROLOGY JOURNAL
LA English
DT Article
DE Overactive bladder; Pathophysiology; j33-Adrenergic receptors;
   j33-Agonists
ID URINARY-TRACT SYMPTOMS; NERVE GROWTH-FACTOR; MESSENGER-RNA EXPRESSION;
   DETRUSOR SMOOTH-MUSCLE; BENIGN PROSTATIC HYPERPLASIA; 3RD
   NATIONAL-HEALTH; BOTULINUM-TOXIN-A; BETA(3)-ADRENOCEPTOR AGONIST; OUTLET
   OBSTRUCTION; AFFERENT ACTIVITY
AB Overactive bladder (OAB) is a symptom-based syndrome defined by urinary urgency, frequency, and nocturia with or without urge incontinence. The causative pathology is diverse; including bladder outlet obstruction (BOO), bladder ischemia, aging, metabolic syndrome, psychological stress, affective disorder, urinary microbiome, localized and systemic inflammatory responses, etc. Several hypotheses have been suggested as mechanisms of OAB generation; among them, neurogenic, myogenic, and urothelial mechanisms are well-known hypotheses. Also, a series of local signals called autonomous myogenic contraction, micromotion, or afferent noises, which can occur during bladder filling, may be induced by the leak of acetylcholine (ACh) or urothelial release of adenosine triphosphate (ATP). They can be transmitted to the central nervous system through afferent fibers to trigger coordinated urgency-related detrusor contractions. Antimuscarinics, commonly known to induce smooth muscle relaxation by competitive blockage of muscarinic receptors in the parasympathetic postganglionic nerve, have a minimal effect on detrusor contraction within therapeutic doses. In fact, they have a predominant role in preventing signals in the afferent nerve transmission process. j33-adrenergic receptor (AR) agonists inhibit afferent signals by predominant inhibition of mechanosensitive A delta-fibers in the normal bladder. However, in pathologic conditions such as spinal cord injury, it seems to inhibit capsaicin-sensitive C-fibers. Particularly, mirabegron, a j33-agonist, prevents ACh release in the BOO-induced detrusor overactivity model by parasympathetic prejunctional mechanisms. A recent study also revealed that vibegron may have 2 mechanisms of action: inhibition of ACh from cholinergic efferent nerves in the detrusor and afferent inhibition via urothelial j33-AR.
C1 [Kwon, Joonbeom; Cho, Kang Jun; Hashimoto, Mamoru; Matsuoka, Kanako; Kamijo, Tadanobu; Wang, Zhou; Tyagi, Pradeep; Yoshimura, Naoki] Univ Pittsburgh, Sch Med, Dept Urol, Suite 700,Kaufmann Med Bldg,3471 Fifth Ave, Pittsburgh, PA 15213 USA.
   [Kwon, Joonbeom] Leaders Urol Clin, Daegu, South Korea.
   [Kim, Duk Yoon] Catholic Univ Daegu, Sch Med, Dept Urol, Daegu, South Korea.
   [Cho, Kang Jun] Catholic Univ Korea, Coll Med, Dept Urol, Seoul, South Korea.
   [Karnup, Sergei; Yoshimura, Naoki] Univ Pittsburgh, Sch Med, Dept Pharmacol & Chem Biol, Pittsburgh, PA 15213 USA.
   [Robertson, Anne M.] Univ Pittsburgh, Sch Bioengn, Dept Mech Engn & Mat Sci, Pittsburgh, PA 15213 USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE); University
   of Pittsburgh; Catholic University of Daegu; Catholic University of
   Korea; Pennsylvania Commonwealth System of Higher Education (PCSHE);
   University of Pittsburgh; Pennsylvania Commonwealth System of Higher
   Education (PCSHE); University of Pittsburgh
RP Yoshimura, N (corresponding author), Univ Pittsburgh, Sch Med, Dept Urol, Suite 700,Kaufmann Med Bldg,3471 Fifth Ave, Pittsburgh, PA 15213 USA.
EM nyos@pitt.edu
RI Cho, Kang Jun/GXF-3772-2022; Kim, Young-Il/ISS-7678-2023
FU National Institutes of Health [R01 DK129194, R01 DK133434, R01 DK134580]
FX The research work by authors has been supported by grants from the
   National Institutes of Health (R01 DK129194 to NY and SK; R01 DK133434
   to AMR and NY; R01 DK134580 to ZW & NY) .
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NR 225
TC 4
Z9 4
U1 2
U2 5
PU KOREAN CONTINENCE SOC
PI YEONGOTONG-GU
PA DEPT UROLOGY, AJOU UNIV COLL MEDICINE, SAN 5 WONCHEN-DONG,
   YEONGOTONG-GU, SUWON 443-721, SOUTH KOREA
SN 2093-4777
EI 2093-6931
J9 INT NEUROUROL J
JI Int. Neurourol. J.
PD FEB
PY 2024
VL 28
SU 1
BP S12
EP S33
DI 10.5213/inj.2448002.001
PG 22
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA KK0E2
UT WOS:001179728400005
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Wilson, PB
   Bohjanen, KA
   Ingraham, SJ
   Leon, AS
AF Wilson, P. B.
   Bohjanen, K. A.
   Ingraham, S. J.
   Leon, A. S.
TI Psoriasis and physical activity: a review
SO JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
LA English
DT Review
ID CORONARY-HEART-DISEASE; C-REACTIVE PROTEIN; OXIDATIVE STRESS BIOMARKERS;
   ADHESION MOLECULES ICAM-1; LOW-DENSITY-LIPOPROTEIN;
   NECROSIS-FACTOR-ALPHA; MIDDLE-AGED MEN; QUALITY-OF-LIFE; METABOLIC
   SYNDROME; RISK-FACTORS
AB Psoriasis is a common, chronic inflammatory skin disease that can cause significant discomfort and impairment to quality of life. Recent research indicates that individuals with moderate-to-severe psoriasis are likely at greater risk for chronic cardiometabolic co-morbidities such as cardiovascular disease, type 2 diabetes, obesity and metabolic syndrome. Physical activity can be an effective primary and adjunctive treatment for these maladies in other populations. Unfortunately, only a limited number of studies have examined physical activity in psoriasis, which are limited by poor design and lack of validated physical activity assessment methodologies. A variety of data suggest shared physiologic pathways between physical activity, psoriasis, and psoriasis cardiometabolic co-morbidities. Increased adiposity, inflammation, oxidative stress, adhesion molecules and lipids are physiologically linked to psoriasis, the risk of psoriasis cardiometabolic co-morbidities, and low levels of physical activity. In addition, epigenetic pathways are involved in psoriasis and could be influenced by physical activity. The physical and psychosocial impairments common in psoriasis may make it difficult to participate in regular physical activity, and future studies should aim to determine if physical activity interventions improve functioning and reduce co-morbidities in psoriasis.
C1 [Wilson, P. B.; Ingraham, S. J.; Leon, A. S.] Univ Minnesota, Sch Kinesiol, Minneapolis, MN USA.
   [Bohjanen, K. A.] Univ Minnesota, Dept Dermatol, Minneapolis, MN 55455 USA.
C3 University of Minnesota System; University of Minnesota Twin Cities;
   University of Minnesota System; University of Minnesota Twin Cities
RP Wilson, PB (corresponding author), Univ Minnesota, Sch Kinesiol, Minneapolis, MN USA.
EM wilso733@umn.edu
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NR 114
TC 40
Z9 44
U1 0
U2 23
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0926-9959
EI 1468-3083
J9 J EUR ACAD DERMATOL
JI J. Eur. Acad. Dermatol. Venereol.
PD NOV
PY 2012
VL 26
IS 11
BP 1345
EP 1353
DI 10.1111/j.1468-3083.2012.04494.x
PG 9
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 026JD
UT WOS:000310271000002
PM 22385402
DA 2025-06-11
ER

PT J
AU Meng, Y
   Eirin, A
   Zhu, XY
   Tang, H
   Chanana, P
   Lerman, A
   van Wijnen, AJ
   Lerman, LO
AF Meng, Yu
   Eirin, Alfonso
   Zhu, Xiang-Yang
   Tang, Hui
   Chanana, Pritha
   Lerman, Amir
   van Wijnen, Andre J.
   Lerman, Lilach O.
TI Obesity-induced mitochondrial dysfunction in porcine adipose
   tissue-derived mesenchymal stem cells
SO JOURNAL OF CELLULAR PHYSIOLOGY
LA English
DT Article
DE mesenchymal stem cells; metabolic syndrome; mitochondria; obesity
ID BONE-MARROW; METABOLIC SYNDROME; STROMAL CELLS; SELF-RENEWAL;
   DIFFERENTIATION; MICRORNA; EXPRESSION; PLASTICITY; APOPTOSIS; INJURY
AB Transplantation of autologous mesenchymal stem cells (MSCs) may be a viable option for treatment of several diseases. MSCs efficacy depends on adequate function of their mitochondria, which might be impaired in a noxious milieu. We hypothesized that obesity compromises MSCs mitochondrial structure and function, possibly via micro-RNA (miRNA)-based mechanisms. MSCs were collected from swine abdominal adipose tissue after 16 weeks of Lean or Obese diet (n=7 each). Mitochondrial structure was assessed by electron microscopy and function by membrane potential and cytochrome-c oxidase (COX)-IV activity. Oxidative stress was assessed by Mito-SOX and dihydroethidium staining. Next-generation sequencing (RNA-seq) was performed to identify miRNAs expression in MSCs, and predicted mitochondrial target genes were then identified (MitoCarta). Compared to Lean-MSCs, mitochondria from Obese-MSCs were smaller and showed cristae remodeling and loss. Mitochondrial membrane potential and COX-IV activity decreased in Obese-MSCs, associated with increased mitochondrial oxidative stress. RNA-seq generated reads for 413 miRNAs, of which 5 miRNAs were upregulated in Obese-MSCs (fold change >2, p<0.05) and found to target 43 specific mitochondrial genes. Obesity impairs MSC mitochondrial structure and function, possibly mediated partly through miRNA-induced mitochondrial gene regulation, leading to increased oxidative stress. Importantly, these alterations may limit the therapeutic use of autologous MSCs in subjects with obesity.
C1 [Meng, Yu; Eirin, Alfonso; Zhu, Xiang-Yang; Tang, Hui; Lerman, Lilach O.] Mayo Clin, Div Nephrol & Hypertens, Dept Med, Rochester, MN USA.
   [Meng, Yu] Jinan Univ, Dept Nephrol, Hosp 1, Guangzhou, Guangdong, Peoples R China.
   [Chanana, Pritha] Mayo Clin, Hlth Sci Res & Biomed Stat & Informat, Rochester, MN USA.
   [Lerman, Amir; Lerman, Lilach O.] Mayo Clin, Cardiovasc Dis, Rochester, MN USA.
   [van Wijnen, Andre J.] Mayo Clin, Orthoped Surg, Rochester, MN USA.
C3 Mayo Clinic; Jinan University; Mayo Clinic; Mayo Clinic; Mayo Clinic
RP Lerman, LO (corresponding author), Mayo Clin, Div Nephrol & Hypertens, 200 First St SW, Rochester, MN 55905 USA.
EM lerman.lilach@mayo.edu
RI Lerman, Lilach/M-4962-2017; Eirin, Alfonso/N-9873-2013; van Wijnen,
   Andre/AAG-3578-2019
OI Eirin, Alfonso/0000-0002-3864-9644; van Wijnen, Andre
   J./0000-0002-4458-0946; Chanana, Pritha/0000-0003-2255-8905
FU National Institute of Diabetes and Digestive and Kidney Diseases
   [DK102325, DK104273, DK106427, DK73608, HL123160]
FX National Institute of Diabetes and Digestive and Kidney Diseases, Grant
   numbers: DK102325, DK104273, DK106427, DK73608, HL123160
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NR 44
TC 42
Z9 43
U1 0
U2 45
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0021-9541
EI 1097-4652
J9 J CELL PHYSIOL
JI J. Cell. Physiol.
PD AUG
PY 2018
VL 233
IS 8
BP 5926
EP 5936
DI 10.1002/jcp.26402
PG 11
WC Cell Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Physiology
GA GD8XM
UT WOS:000430797600039
PM 29243809
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Lohr, M
   Jensen, A
   Eriksen, L
   Gronbæk, M
   Loft, S
   Moller, P
AF Lohr, Mille
   Jensen, Annie
   Eriksen, Louise
   Gronbaek, Morten
   Loft, Steffen
   Moller, Peter
TI Age and metabolic risk factors associated with oxidatively damaged DNA
   in human peripheral blood mononuclear cells
SO ONCOTARGET
LA English
DT Article
DE 8-oxodG; comet assay; metabolic syndrome; obesity; oxidative stress
ID COMET ASSAY; FATTY-ACIDS; INSULIN-RESISTANCE; STRAND BREAKS; STRESS;
   REPAIR; 8-OXO-7,8-DIHYDRO-2'-DEOXYGUANOSINE; INFLAMMATION; POPULATION;
   CANCER
AB Aging is associated with oxidative stress-generated damage to DNA and this could be related to metabolic disturbances. This study investigated the association between levels of oxidatively damaged DNA in peripheral blood mononuclear cells (PBMCs) and metabolic risk factors in 1,019 subjects, aged 18-93 years. DNA damage was analyzed as strand breaks by the comet assay and levels of formamidopyrimidine (FPG-) and human 8-oxoguanine DNA glycosylase 1 (hOGG1)-sensitive sites There was an association between age and levels of FPG-sensitive sites for women, but not for men. The same tendency was observed for the level of hOGG1-sensitive sites, whereas there was no association with the level of strand breaks. The effect of age on oxidatively damaged DNA in women disappeared in multivariate models, which showed robust positive associations between DNA damage and plasma levels of triglycerides, cholesterol and glycosylated hemoglobin (HbA(1c)). In the group of men, there were significant positive associations between alcohol intake, HbA(1c) and FPG-sensitive sites in multivariate analysis. The levels of metabolic risk factors were positively associated with age, yet only few subjects fulfilled all metabolic syndrome criteria. In summary, positive associations between age and levels of oxidatively damaged DNA appeared mediated by age-related increases in metabolic risk factors.
C1 [Lohr, Mille; Jensen, Annie; Loft, Steffen; Moller, Peter] Univ Copenhagen, Dept Publ Hlth, Environm Hlth Sect, Copenhagen, Denmark.
   [Eriksen, Louise; Gronbaek, Morten] Univ Southern Denmark, Natl Inst Publ Hlth, Odense, Denmark.
C3 University of Copenhagen; University of Southern Denmark
RP Moller, P (corresponding author), Univ Copenhagen, Dept Publ Hlth, Environm Hlth Sect, Copenhagen, Denmark.
EM pemo@sund.ku.dk
OI Loft, Steffen/0000-0001-9552-8518; Gronbaek, Morten
   Klocker/0000-0002-8473-6474
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NR 56
TC 36
Z9 37
U1 0
U2 7
PU IMPACT JOURNALS LLC
PI ORCHARD PARK
PA 6666 E QUAKER ST, STE 1, ORCHARD PARK, NY 14127 USA
EI 1949-2553
J9 ONCOTARGET
JI Oncotarget
PD FEB 20
PY 2015
VL 6
IS 5
BP 2641
EP 2653
DI 10.18632/oncotarget.3202
PG 13
WC Oncology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Cell Biology
GA CF6VK
UT WOS:000352694400008
PM 25650665
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU de Souza, GA
   de Marqui, SV
   Matias, JN
   Guiguer, EL
   Barbalho, SM
AF de Souza, Gabriela Achete
   de Marqui, Samylla Vaz
   Matias, Julia Novaes
   Guiguer, Elen Landgraf
   Barbalho, Sandra Maria
TI Effects of Ginkgo biloba on Diseases Related to Oxidative Stress
SO PLANTA MEDICA
LA English
DT Review
DE Ginkgo biloba; Ginkgoceae; antioxidant; oxidative stress;
   anti-inflammatory
ID EXTRACT-EGB 761; LEAF EXTRACT; NEUROPROTECTIVE ROLE; COGNITIVE FUNCTION;
   METABOLIC SYNDROME; L. EXTRACT; INJURY; INHIBITION; EFFICACY; DAMAGE
AB Ginkgo biloba (GB) is one of the most widely used phytotherapeutic products in the world, and its extract has beneficial properties for the treatment of several pathologies, such as diabetic cardiomyopathy, neurodegenerative diseases, cataracts, hearing loss, myocardial lesion, hippocampus neuronal lesions, morphometry testicular changes, and liver damage. This review aims to investigate the effects of GB on diseases related to oxidative stress. Databases such as MEDLINE/PUBMED and EMBASE were consulted, and PRISMA guidelines were used to build the review. This plant has antioxidant properties since it regulates the expression of antioxidant enzymes positively and reduces reactive oxygen and nitrogen species, contributing to the reduction of lipid peroxidation. It also exhibits anti-inflammatory properties, inhibiting the expression of pro-inflammatory cytokines, such as IL-1, IL-6, and TNF- alpha . In animal models, the use of GB can show positive effects on brain damage, neurodegenerative diseases, myocardial injury, and renal and liver damage. In humans, the positive effects were shown in diabetes, metabolic syndrome, and ischemic colitis. These effects are due to the presence of compounds such as bilobalide, isoramnetina, quercetin, kaempferol, and ginkgolides A, B, and C. For these reasons, GB can be a low-cost alternative to the therapeutic approach of several pathologies since it acts in the prevention, treatment, and inhibition of several complications of common comorbidities.
C1 [de Souza, Gabriela Achete; de Marqui, Samylla Vaz; Matias, Julia Novaes; Guiguer, Elen Landgraf; Barbalho, Sandra Maria] Univ Marilia UNIMAR, Sch Med, Dept Biochem & Pharmacol, Marilia, SP, Brazil.
   [Guiguer, Elen Landgraf; Barbalho, Sandra Maria] Fac Food Technol Marilia, FATEC, Dept Biochem & Nutr, Marilia, SP, Brazil.
C3 Universidade de Marilia
RP Barbalho, SM (corresponding author), Univ Marilia, Sch Med, Dept Biochem & Pharmacol, Ave Higino Muzzi Filho 1001, BR-17525902 Marilia, SP, Brazil.
EM smbarbalho@gmail.com
RI barbalho, sandra/Z-3515-2019; Guiguer, Elen/AAN-1883-2020
OI Novaes Matias, Julia/0000-0003-0265-3016; Guiguer,
   Elen/0000-0002-9930-9694; Achete de Souza, Gabriela/0000-0002-5612-3486
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NR 78
TC 74
Z9 80
U1 0
U2 42
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0032-0943
EI 1439-0221
J9 PLANTA MED
JI Planta Med.
PD APR
PY 2020
VL 86
IS 6
BP 376
EP 386
DI 10.1055/a-1109-3405
PG 11
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA LE7HE
UT WOS:000526892900001
PM 32097975
OA Bronze
DA 2025-06-11
ER

PT J
AU Yamato, M
   Shiba, T
   Yoshida, M
   Ide, T
   Seri, N
   Kudou, W
   Kinugawa, S
   Tsutsui, H
AF Yamato, Mayumi
   Shiba, Takeshi
   Yoshida, Masayoshi
   Ide, Tomomi
   Seri, Naoko
   Kudou, Wataru
   Kinugawa, Shintaro
   Tsutsui, Hiroyuki
TI Fatty acids increase the circulating levels of oxidative stress factors
   in mice with diet-induced obesity via redox changes of albumin
SO FEBS JOURNAL
LA English
DT Article
DE ESR; albumin; fatty acid; obesity; oxidative stress
ID PERFORMANCE LIQUID-CHROMATOGRAPHY; INDUCED INSULIN-RESISTANCE;
   SKELETAL-MUSCLE CELLS; HUMAN-SERUM-ALBUMIN; METABOLIC SYNDROME;
   LIPID-PEROXIDATION; BINDING-SITES; ANTIOXIDANT; PLASMA; MECHANISM
AB Plasma concentrations of free fatty acids are increased in metabolic syndrome, and the increased fatty acids may cause cellular damage via the induction of oxidative stress. The present study was designed to determine whether the increase in fatty acids can modify the free sulfhydryl group in position 34 of albumin (Cys34) and enhance the redox-cycling activity of the copper-albumin complex in high-fat diet-induced obese mice. The mice were fed with commercial normal diet or high-fat diet. and water ad libitum for 3 months. The high-fat diet-fed mice developed obesity, hyperlipemia, and hyperglycemia. The plasma fatty acid/albumin ratio also significantly increased in high-fat diet-fed mice. The increased fatty acid/albumin ratio was associated with conformational changes in albumin and the oxidation of sulfhydryl groups. Moreover, an ascorbic acid radical, an index of redox-cycling activity of the copper-albumin complex, was detected only in the plasma from obese mice, whereas the plasma concentrations of ascorbic acid were not altered. Plasma thiobarbituric acid reactive substances were significantly increased in the high-fat diet group. These results indicate that the increased plasma fatty acids in the high-fat diet group resulted in the activated redox cycling of the copper albumin complex and excessive lipid peroxidation.
C1 Hokkaido Univ, Grad Sch Med, Dept Cardiovasc Med, Kita Ku, Sapporo, Hokkaido 060, Japan.
   Kyushu Univ, Grad Sch Med Sci, Dept Cardiovasc Med, Fukuoka 812, Japan.
   Kyushu Univ, Fac Pharmaceut Sci, Dept REDOX Med Sci, Fukuoka 812, Japan.
C3 Hokkaido University; Kyushu University; Kyushu University
RP Tsutsui, H (corresponding author), Hokkaido Univ, Grad Sch Med, Dept Cardiovasc Med, Kita Ku, Kita-15,Nishi-7, Sapporo, Hokkaido 060, Japan.
EM htsutsui@med.hokudai.ac.jp
RI Kinugawa, Shintaro/E-1268-2012; Tsutsui, Hiroyuki/A-4070-2012
OI Yoshida, Masayoshi/0000-0002-5207-5544
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NR 38
TC 39
Z9 43
U1 0
U2 6
PU BLACKWELL PUBLISHING
PI OXFORD
PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND
SN 1742-464X
J9 FEBS J
JI FEBS J.
PD AUG
PY 2007
VL 274
IS 15
BP 3855
EP 3863
DI 10.1111/j.1742-4658.2007.05914.x
PG 9
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 199UG
UT WOS:000248720100008
PM 17617229
DA 2025-06-11
ER

PT J
AU Chen, K
   Wang, G
   Jin, HZ
   Xu, JH
   Zhu, XJ
   Zheng, M
   Gu, H
AF Chen, Kun
   Wang, Gang
   Jin, Hongzhong
   Xu, Jinhua
   Zhu, Xuejun
   Zheng, Min
   Gu, Heng
TI Clinic characteristics of psoriasis in China: a nationwide survey in
   over 12000 patients
SO ONCOTARGET
LA English
DT Article
DE psoriasis; epidemiology; phenotype; Chinese Han
ID METABOLIC SYNDROME; PREVALENCE; RISK; HYPERTENSION; ARTHRITIS; SMOKING;
   DISEASE
AB Psoriasis is a worldwide chronic inflammatory disease, involving both skin and joints. In order to characterize psoriasis in Han Chinese population, we conducted this nationwide prospective and hospital based survey, in which 56 hospitals with departments of dermatology participated, located in 33 cities across China. A total of 12,031 outpatients with psoriasis were registered during 2009 to 2010, which the data was collected by standard questionnaires. The main data acquisition included demographics, family history, disease status and other comorbidities. Physical and dermatological examination, including body surface area (BSA) and psoriasis area severity index ( PASI) were applied to evaluate the disease severity. Descriptive statistics, 2 tailed t-test and chi-square test were used appropriately for the statistical analysis. From the study, we found that the male and female ratio of the patients was 1.49: 1. Mean age of onset was 30.2 +/- 14.5 years for males and 27.1 +/- 15.6 years for females (P < 0.05). Scalp was the most common onset site (52.8%), The mean PASI was 18.70 +/- 10.01, indicating that most patients presenting at the hospitals had moderate-to-severe psoriasis and the majority was psoriasis vulgaris (96.5%). Among 12,031 patients, 23.1% had a family history of psoriasis, 16.1% had comorbidities, and 29.9% had nail changes. The most important aggravation factor was season change (60.2%), followed by psychological stress (34.5%), and there significant differences between genders on trigger factors. In conclusion, this study characterizing psoriasis in Han Chinese population, could be used as basic data for future study.
C1 [Chen, Kun; Gu, Heng] Chinese Acad Med Sci, Inst Dermatol, Nanjing, Jiangsu, Peoples R China.
   [Chen, Kun; Gu, Heng] Peking Union Med Coll, Nanjing, Jiangsu, Peoples R China.
   [Wang, Gang] Fourth Mil Med Univ, Xijing Hosp, Dept Dermatol, Xian, Shanxi, Peoples R China.
   [Jin, Hongzhong] Chinese Acad Med Sci, Peking Union Med Hosp, Beijing, Peoples R China.
   [Jin, Hongzhong] Peking Union Med Coll, Beijing, Peoples R China.
   [Xu, Jinhua] Fudan Univ, Huashan Hosp, Dept Dermatol, Shanghai, Peoples R China.
   [Zhu, Xuejun] Peking Univ, Hosp 1, Dept Dermatol, Beijing, Peoples R China.
   [Zheng, Min] Zhejiang Univ, Sch Med, Dept Dermatol, Affiliated Hosp 2, Hangzhou, Zhejiang, Peoples R China.
C3 Chinese Academy of Medical Sciences - Peking Union Medical College;
   Institute of Dermatology - CAMS; Chinese Academy of Medical Sciences -
   Peking Union Medical College; Peking Union Medical College; Air Force
   Medical University; Chinese Academy of Medical Sciences - Peking Union
   Medical College; Peking Union Medical College Hospital; Chinese Academy
   of Medical Sciences - Peking Union Medical College; Peking Union Medical
   College; Fudan University; Peking University; Zhejiang University
RP Gu, H (corresponding author), Chinese Acad Med Sci, Inst Dermatol, Nanjing, Jiangsu, Peoples R China.; Gu, H (corresponding author), Peking Union Med Coll, Nanjing, Jiangsu, Peoples R China.; Zheng, M (corresponding author), Zhejiang Univ, Sch Med, Dept Dermatol, Affiliated Hosp 2, Hangzhou, Zhejiang, Peoples R China.
EM minz@zju.edu.cn; guhengy@yahoo.com.cn
RI Zheng, Mingyue/HHZ-4062-2022; Wang, Gang/H-6710-2019
OI Zhang, Jiahe/0000-0003-4147-394X; Wang, Gang/0000-0002-5842-8080
FU Leo Pharmaceutical Co., Shanghai, China; CAMS Innovation Fund for
   Medical Sciences [2016-12M-1-005]
FX This epidemiologic investigation into psoriasis was funded by Leo
   Pharmaceutical Co., Shanghai, China. And this work was supported by CAMS
   Innovation Fund for Medical Sciences (2016-12M-1-005). We extend our
   sincere thanks to Dr. Peter Pothula,BioQuest for his valuable editorial
   guidance and Dr. Stephan Weidinger, Kiel, for critical reading of the
   manuscript.
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NR 27
TC 48
Z9 58
U1 0
U2 10
PU IMPACT JOURNALS LLC
PI ORCHARD PARK
PA 6666 E QUAKER ST, STE 1, ORCHARD PARK, NY 14127 USA
EI 1949-2553
J9 ONCOTARGET
JI Oncotarget
PD JUL 11
PY 2017
VL 8
IS 28
BP 46381
EP 46389
DI 10.18632/oncotarget.18453
PG 9
WC Oncology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Cell Biology
GA FA5SS
UT WOS:000405504600116
PM 28637026
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Matrisciano, F
AF Matrisciano, Francesco
TI Functional Nutrition as Integrated Intervention for In- and Outpatient
   with Schizophrenia
SO CURRENT NEUROPHARMACOLOGY
LA English
DT Review
DE Schizophrenia; neuroinflammation; synaptic plasticity; nutrition;
   functional foods; bioactive compounds
ID EPIGENETIC MODIFICATIONS; OXIDATIVE STRESS; ANTIINFLAMMATORY AGENTS;
   GABAERGIC INTERNEURONS; INHIBITORY NEURONS; METABOLIC SYNDROME; BIPOLAR
   DISORDER; PRENATAL STRESS; RISK-FACTORS; INFLAMMATION
AB Schizophrenia is a chronic and progressive disorder characterized by cognitive, emotional, and behavioral abnormalities associated with neuronal development and synaptic plasticity alterations. Genetic and epigenetic abnormalities in cortical parvalbumin-positive GABAergic interneurons and consequent alterations in glutamate-mediated excitatory neurotransmission during early neurodevelopment underlie schizophrenia manifestation and progression. Also, epigenetic alterations during pregnancy or early phases of postnatal life are associated with schizophrenia vulnerability and inflammatory processes, which are at the basis of brain pathology and a higher risk of comorbidities, including cardiovascular diseases and metabolic syndrome. In addition, schizophrenia patients adopt an unhealthy lifestyle and poor nutrition, leading to premature death. Here, I explored the role of functional nutrition as an integrated intervention for the long-term management of patients with schizophrenia. Several natural bioactive compounds in plant-based whole foods, including flavonoids, phytonutrients, vitamins, fatty acids, and minerals, modulate brain functioning by targeting neuroinflammation and improving cognitive decline. Although further clinical studies are needed, a functional diet rich in natural bioactive compounds might be effective in synergism with standard treatments to improve schizophrenia symptoms and reduce the risk of comorbidities.
C1 [Matrisciano, Francesco] Univ Illinois Chicago UIC, Psychiat Inst, Coll Med, Dept Psychiat, Chicago, IL 60607 USA.
C3 University of Illinois System; University of Illinois Chicago
RP Matrisciano, F (corresponding author), Univ Illinois Chicago UIC, Psychiat Inst, Coll Med, Dept Psychiat, Chicago, IL 60607 USA.
EM matrisci@uic.edu
FU "Sorgente srl" - Mental Health Community, Italy.; "Sorgente srl" -
   Mental Health Community, Italy
FX "Sorgente srl" - Mental Health Community, Italy.
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NR 153
TC 2
Z9 2
U1 0
U2 5
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1570-159X
EI 1875-6190
J9 CURR NEUROPHARMACOL
JI Curr. Neuropharmacol.
PY 2023
VL 21
IS 12
BP 2409
EP 2423
DI 10.2174/1570159X21666230322160259
PG 15
WC Neurosciences; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pharmacology & Pharmacy
GA U8WP8
UT WOS:001087552300003
PM 36946488
OA Green Published
DA 2025-06-11
ER

PT J
AU Davis, CR
   Dearing, E
   Usher, N
   Trifiletti, S
   Zaichenko, L
   Ollen, E
   Brinkoetter, MT
   Crowell-Doom, C
   Joung, K
   Park, KH
   Mantzoros, CS
   Crowell, JA
AF Davis, Cynthia R.
   Dearing, Eric
   Usher, Nicole
   Trifiletti, Sarah
   Zaichenko, Lesya
   Ollen, Elizabeth
   Brinkoetter, Mary T.
   Crowell-Doom, Cindy
   Joung, Kyoung
   Park, Kyung Hee
   Mantzoros, Christos S.
   Crowell, Judith A.
TI Detailed assessments of childhood adversity enhance prediction of
   central obesity independent of gender, race, adult psychosocial risk and
   health behaviors
SO METABOLISM-CLINICAL AND EXPERIMENTAL
LA English
DT Article
DE Central obesity; Childhood adversity; Psychosocial risk factors;
   Modifiable risk factors
ID METABOLIC SYNDROME; PSYCHOLOGICAL STRESS; ADIPOSE-TISSUE; US POPULATION;
   LIFE-COURSE; ABUSE; PATHWAYS; DISEASE; AXIS; AGE
AB Objective. This study examined whether a novel indicator of overall childhood adversity, incorporating number of adversities, severity, and chronicity, predicted central obesity beyond contributions of "modifiable" risk factors including psychosocial characteristics and health behaviors in a diverse sample of midlife adults. The study also examined whether the overall adversity score (number of adversities x severity x chronicity) better predicted obesity compared to cumulative adversity (number of adversities), a more traditional assessment of childhood adversity.
   Materials/Methods. 210 Black/African Americans and White/European Americans, mean age = 45.8; +/- 3.3 years, were studied cross-sectionally. Regression analysis examined overall childhood adversity as a direct, non-modifiable risk factor for central obesity (waist hip ratio) and body mass index (BMI), with and without adjustment for established adult psychosocial risk factors (education, employment, social functioning) and heath behavior risk factors (smoking, drinking, diet, exercise).
   Results. Overall childhood adversity was an independent significant predictor of central obesity, and the relations between psychosocial and health risk factors and central obesity were not significant when overall adversity was in the model. Overall adversity was not a statistically significant predictor of BMI.
   Conclusions. Overall childhood adversity, incorporating severity and chronicity and cumulative scores, predicts central obesity beyond more contemporaneous risk factors often considered modifiable. This is consistent with early dysregulation of metabolic functioning. Findings can inform practitioners interested in the impact of childhood adversity and personalizing treatment approaches of obesity within high-risk populations. Prevention/intervention research is necessary to discover and address the underlying causes and impact of childhood adversity on metabolic functioning. (C) 2014 Elsevier Inc. All rights reserved.
C1 [Davis, Cynthia R.; Usher, Nicole; Trifiletti, Sarah; Ollen, Elizabeth; Crowell-Doom, Cindy; Crowell, Judith A.] Judge Baker Childrens Ctr, Boston, MA 02120 USA.
   [Dearing, Eric] Boston Coll, Boston, MA USA.
   [Zaichenko, Lesya; Brinkoetter, Mary T.; Joung, Kyoung; Park, Kyung Hee; Mantzoros, Christos S.] Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Div Endocrinol Diabet & Metab, Boston, MA 02215 USA.
   [Brinkoetter, Mary T.; Joung, Kyoung] Boston Childrens Hosp, Div Newborn Med, Boston, MA USA.
   [Park, Kyung Hee] Hallym Univ, Sacred Heart Hosp, Dept Family Med, Gyeonggi Do, South Korea.
   [Mantzoros, Christos S.] Harvard Univ, Sch Med, Boston VA Healthcare Syst, Endocrinol Sect, Boston, MA USA.
   [Crowell, Judith A.] SUNY Stony Brook, Dept Psychiat & Behav Sci, Sch Med, Stony Brook, NY 11794 USA.
C3 Harvard University; Harvard University Medical Affiliates; Judge Baker's
   Children's Center; Boston College; Harvard University; Harvard
   University Medical Affiliates; Beth Israel Deaconess Medical Center;
   Harvard Medical School; Harvard University; Harvard University Medical
   Affiliates; Boston Children's Hospital; Hallym University; Harvard
   University; Harvard Medical School; Harvard University Medical
   Affiliates; US Department of Veterans Affairs; Veterans Health
   Administration (VHA); VA Boston Healthcare System; State University of
   New York (SUNY) System; Stony Brook University
RP Davis, CR (corresponding author), Judge Baker Childrens Ctr, 53 Parker Hill Ave, Boston, MA 02120 USA.
EM crdavis@jbcc.harvard.edu
RI Park, Kyung/AAU-7867-2020; Mantzoros, Christos/Y-2902-2019
OI Zaichenko, Lesya/0000-0001-8489-3886; Park, Kyung
   Hee/0000-0001-9806-0076; Joung, Kyoung Eun/0000-0002-5942-4241
FU National Institute of Aging [AG032030]; National Institute of Diabetes
   and Digestive and Kidney Diseases grant [81913]; Harvard Clinical and
   Translational Science Center, from the National Center for Research
   Resources [UL1 RR025758]
FX Grant Support: This study was supported by the National Institute of
   Aging, grant AG032030, and National Institute of Diabetes and Digestive
   and Kidney Diseases grant 81913. The project described was supported by
   Grant Number UL1 RR025758 Harvard Clinical and Translational Science
   Center, from the National Center for Research Resources. The content is
   solely the responsibility of the authors and does not necessarily
   represent the official views of the National Center for Research
   Resources or the National Institutes of Health.
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NR 61
TC 51
Z9 61
U1 1
U2 42
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0026-0495
EI 1532-8600
J9 METABOLISM
JI Metab.-Clin. Exp.
PD FEB
PY 2014
VL 63
IS 2
BP 199
EP 206
DI 10.1016/j.metabol.2013.08.013
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism
GA 299SF
UT WOS:000330415300007
PM 24211017
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Qiu, YN
   Zheng, Z
   Kim, H
   Yang, Z
   Zhang, G
   Shi, XY
   Sun, F
   Peng, CY
   Ding, YC
   Wang, AX
   Chen, LC
   Rajagopalan, S
   Sun, QH
   Zhang, KZ
AF Qiu, Yining
   Zheng, Ze
   Kim, Hyunbae
   Yang, Zhao
   Zhang, Gary
   Shi, Xiangyang
   Sun, Fei
   Peng, Changya
   Ding, Yuchuan
   Wang, Aixia
   Chen, Lung-Chi
   Rajagopalan, Sanjay
   Sun, Qinghua
   Zhang, Kezhong
TI Inhalation Exposure to PM2.5 Counteracts Hepatic Steatosis in
   Mice Fed High-fat Diet by Stimulating Hepatic Autophagy
SO SCIENTIFIC REPORTS
LA English
DT Article
ID AIR-POLLUTION EXPOSURE; ELEMENT-BINDING PROTEIN; STRESS;
   STEATOHEPATITIS; LIPOGENESIS; OBESITY; ACIDS
AB Air pollution is associated with the increased risk of metabolic syndrome. In this study, we performed inhalation exposure of mice fed normal chow or a high-fat diet to airborne fine particulate matters (PM2.5), and then investigated the complex effects and mechanisms of inhalation exposure to PM2.5 on hepatic steatosis, a precursor or manifestation of metabolic syndrome. Our studies demonstrated that inhalation exposure of mice fed normal chow to concentrated ambient PM2.5 repressed hepatic transcriptional regulators involved in fatty acid oxidation and lipolysis, and thus promoted hepatic steatosis. However, PM2.5 exposure relieved hepatic steatosis in high-fat diet-induced obese mice. Further investigation revealed that inhalation exposure to PM2.5 induced hepatic autophagy in mouse livers in a manner depending on the MyD88-mediated inflammatory pathway. The counteractive effect of PM2.5 exposure on high-fat diet-induced hepatic steatosis was mediated through PM2.5-induced hepatic autophagy. The findings from this study not only defined the effects and mechanisms of PM2.5 exposure in metabolic disorders, but also revealed the pleotrophic acts of an environmental stressor in a complex stress system relevant to public health.
C1 [Qiu, Yining; Zheng, Ze; Kim, Hyunbae; Yang, Zhao; Zhang, Gary; Zhang, Kezhong] Wayne State Univ, Sch Med, Ctr Mol Med & Genet, Detroit, MI 48201 USA.
   [Zhang, Kezhong] Wayne State Univ, Sch Med, Dept Microbiol Immunol & Biochem, Detroit, MI 48201 USA.
   [Peng, Changya; Ding, Yuchuan] Wayne State Univ, Sch Med, Dept Neurosurg, Detroit, MI 48201 USA.
   [Sun, Fei] Wayne State Univ, Sch Med, Dept Physiol, Detroit, MI 48201 USA.
   [Wang, Aixia; Sun, Qinghua] Ohio State Univ, Davis Heart & Lung Res Inst, Div Cardiovasc Med, Coll Med, Columbus, OH 43210 USA.
   [Sun, Qinghua] Ohio State Univ, Div Environm Hlth Sci, Coll Publ Hlth, Columbus, OH 43210 USA.
   [Rajagopalan, Sanjay] Case Western Reserve Univ, Case Cardiovasc Res Inst, Sch Med, 11100 Euclid Ave, Cleveland, OH 44106 USA.
   [Chen, Lung-Chi] NYU, Dept Environm Med, Tuxedo Pk, NY 10987 USA.
   [Qiu, Yining] Huazhong Univ Sci & Technol, Union Hosp, Dept Pediat, Tongji Med Coll, Wuhan 430022, Hubei, Peoples R China.
   [Shi, Xiangyang] Donghua Univ, Coll Chem Chem Engn & Biotechnol, State Key Lab Modificat Chem Fibers & Polymer Mat, Shanghai 201620, Peoples R China.
C3 Wayne State University; Wayne State University; Wayne State University;
   Wayne State University; University System of Ohio; Ohio State
   University; University System of Ohio; Ohio State University; University
   System of Ohio; Case Western Reserve University; New York University;
   Huazhong University of Science & Technology; Donghua University
RP Zhang, KZ (corresponding author), Wayne State Univ, Sch Med, Ctr Mol Med & Genet, Detroit, MI 48201 USA.; Zhang, KZ (corresponding author), Wayne State Univ, Sch Med, Dept Microbiol Immunol & Biochem, Detroit, MI 48201 USA.
EM kzhang@med.wayne.edu
RI Zhang, Zhiwu/P-6156-2016; Sun, Qinghua/E-4167-2011; Shi,
   Xiangyang/A-1289-2007
OI JIANG, BIN/0009-0009-0519-2527; Yang, Zhao/0000-0002-4133-3130; Zhang,
   Kezhong/0000-0002-6062-235X; Chen, Lung Chi/0000-0003-1154-2107; Shi,
   Xiangyang/0000-0001-6785-6645; Zheng, Ze/0000-0002-4453-224X; Peng,
   Changya/0009-0004-3217-8476
FU National Institutes of Health (NIH) [DK090313, ES017829]; American Heart
   Association [0635423Z, 09GRNT2280479]; NIH [ES016588, ES017412,
   ES018900, ES019616]; National Institute of Diabetes and Digestive and
   Kidney Diseases [P30DK020572] Funding Source: NIH RePORTER; American
   Heart Association (AHA) [0635423Z] Funding Source: American Heart
   Association (AHA)
FX Portions of this work were supported by National Institutes of Health
   (NIH) grants DK090313 and ES017829 to KZ, American Heart Association
   Grants 0635423Z and 09GRNT2280479 to KZ, NIH grants ES016588, ES017412,
   and ES018900 to QS, and NIH grants ES019616 to SR. Gary Zhang is a high
   school student at the Salem High School of Michigan who was a summer
   student research volunteer at the Center for Molecular Medicine and
   Genetics of Wayne State University School of Medicine.
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NR 35
TC 25
Z9 26
U1 1
U2 22
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD NOV 24
PY 2017
VL 7
AR 16286
DI 10.1038/s41598-017-16490-3
PG 11
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA FN6OL
UT WOS:000416135000085
PM 29176715
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Sun, KL
   Watson, KT
   Angal, S
   Bakkila, BF
   Gorelik, AJ
   Leslie, SM
   Rasgon, NL
   Singh, MK
AF Sun, Kevin L.
   Watson, Kathleen T.
   Angal, Sarthak
   Bakkila, Baylee F.
   Gorelik, Aaron J.
   Leslie, Sara M.
   Rasgon, Natalie L.
   Singh, Manpreet K.
TI Neural and Endocrine Correlates of Early Life Abuse in Youth With
   Depression and Obesity
SO FRONTIERS IN PSYCHIATRY
LA English
DT Article
DE pediatric depression; obesity; insulin resistance; early life stress;
   abuse; resting state functional connectivity; diabetes
ID STATE FUNCTIONAL CONNECTIVITY; CHILDHOOD PHYSICAL ABUSE;
   INSULIN-RESISTANCE; RECEPTOR AVAILABILITY; SOCIOECONOMIC-STATUS;
   METABOLIC SYNDROME; SOCIAL-STATUS; STRESS; ADOLESCENT; OVERWEIGHT
AB Depression and insulin resistance are becoming increasingly prevalent in younger populations. The origin and consequence of insulin resistance in depressed youth may, in part, be rooted in exposure to environmental stressors, such as early life abuse, that may lead to aberrant brain motivational networks mediating maladaptive food-seeking behaviors and insipient insulin resistance. In this paper, we aimed to investigate the impact of early life abuse on the development of insulin resistance in depressed and overweight youth aged 9 to 17 years. We hypothesized that youth with the greatest burden of early life abuse would have the highest levels of insulin resistance and corresponding aberrant reward network connectivities. To test this hypothesis, we evaluated sixty-nine depressed and overweight youth aged 9 to 17, using multimodal assessments of early life abuse, food-seeking behavior, and insulin resistance. Based on results of the Childhood Trauma Questionnaire (CTQ), we separated our study participants into two groups: 35 youth who reported high levels of the sum of emotional, physical, or sexual abuse and 34 youth who reported insignificant or no levels of any abuse. Results of an oral glucose tolerance test (OGTT) and resting state functional connectivity (RSFC), using the amygdala, insula, and nucleus accumbens (NAcc) as seed-based reward network regions of interest, were analyzed for group differences between high abuse and low abuse groups. High abuse youth exhibited differences from low abuse youth in amygdala-precuneus, NAcc-paracingulate gyrus, and NAcc-prefrontal cortex connectivities, that correlated with levels of abuse experienced. The more different their connectivity from of that of low abuse youth, the higher were their fasting glucose and glucose at OGTT endpoint. Importantly, level of abuse moderated the relation between reward network connectivity and OGTT glucose response. In contrast, low abuse youth showed hyperinsulinemia and more insulin resistance than high abuse youth, and their higher OGTT insulin areas under the curve correlated with more negative insula-precuneus connectivity. Our findings suggest distinct neural and endocrine profiles of youth with depression and obesity based on their histories of early life abuse.
C1 [Sun, Kevin L.; Watson, Kathleen T.; Angal, Sarthak; Bakkila, Baylee F.; Gorelik, Aaron J.; Leslie, Sara M.; Rasgon, Natalie L.; Singh, Manpreet K.] Stanford Univ, Sch Med, Dept Psychiat & Behav Sci, Stanford, CA 94305 USA.
C3 Stanford University
RP Singh, MK (corresponding author), Stanford Univ, Sch Med, Dept Psychiat & Behav Sci, Stanford, CA 94305 USA.
EM mksingh@stanford.edu
RI Rasgon, Natalie/ABH-9813-2020; Gorelik, Aaron/AAV-1922-2020; Singh,
   Manpreet/L-1068-2014
OI Bakkila, Baylee/0000-0001-9506-1831; Gorelik, Aaron/0000-0002-2589-1220;
   Leslie, Sara/0000-0002-5557-4293; Sun, Kevin Lee/0000-0003-1904-6570;
   Singh, Manpreet/0000-0002-4373-3293
FU National Institute of Mental Health [R01MH106581]; National Institute of
   Aging [R01AG050345]
FX This work was supported by the National Institute of Mental Health
   (R01MH106581) and the National Institute of Aging (R01AG050345).
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NR 106
TC 12
Z9 12
U1 2
U2 23
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-0640
J9 FRONT PSYCHIATRY
JI Front. Psychiatry
PD DEC 21
PY 2018
VL 9
AR 721
DI 10.3389/fpsyt.2018.00721
PG 14
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA HF2QX
UT WOS:000454082600001
PM 30622489
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Barbosa, BJAP
   de Souza-Talarico, JN
   de Jesus, MCF
   Mota, GPS
   de Oliveira, MO
   Cassimiro, L
   Avolio, IMB
   Trés, ES
   Borges, CR
   Teixeira, TBM
   Brucki, SMD
AF Barbosa, Breno Jose Alencar Pires
   de Souza-Talarico, Juliana Nery
   de Jesus, Maria Clara Ferreira
   Mota, Gabriel Paz Souza
   de Oliveira, Maira Okada
   Cassimiro, Luciana
   Avolio, Isabella Maria Bello
   Tres, Eduardo Sturzeneker
   Borges, Conrado Regis
   Teixeira, Thiago Bezerra Moraes
   Brucki, Sonia Maria Dozzi
TI Allostatic load measures in older adults with subjective cognitive
   decline and mild cognitive impairment: A cross-sectional analysis from
   the Brazilian Memory and Aging Study
SO CLINICAL NEUROLOGY AND NEUROSURGERY
LA English
DT Article
DE Physiological stress; Cognitive dysfunction; Alzheimer's disease;
   Allostasis; Metabolic syndrome; Aging
ID PERCEIVED STRESS SCALE; ALZHEIMERS-DISEASE; PHYSIOLOGICAL DYSREGULATION;
   DEMENTIA PREVENTION; METABOLIC SYNDROME; BRAIN; CORTISOL; RISK;
   INTERVENTION; ASSOCIATION
AB Introduction: An increasing body of research suggests that stress and allostatic load are related to cognitive dysfunction and neurodegeneration. Objectives: to determine the relationship between allostatic load (AL) and cognitive status in older adults classified with subjective cognitive decline (SCD) and mild cognitive impairment (MCI). Methodology: Using the Brazilian Memory and Aging Study (BRAMS) database, we analyzed data from 57 older adults with SCD and MCI. Blood neuroendocrine (cortisol, DHEA-s), inflammatory (C -reactive protein, fibrinogen), metabolic (HbA1c, HDL-cholesterol, total cholesterol, creatinine), and cardiovascular (blood pressure, waist/hip ratio) were transformed into an AL index. Results: Despite a significant difference in the univariate analysis between waist/hip ratio (0.94 in the MCI group vs. 0, 88 in the SCD group, p = 0.03), total cholesterol levels (194 vs. 160, p = 0.02), and AL index (36.9 % in the MCI group vs. 27.2 % in the SCD group, p = 0.04), AL was not associated with SCD or MCI in the multivariate analysis. Conclusion: Our data suggest that different profiles of AL in MCI compared to individuals with SCD could be due to cofounding factors. These findings need to be confirmed in longitudinal studies investigating profiles of AL changes at preclinical and prodromal stages of Alzheimer's disease.
C1 [Barbosa, Breno Jose Alencar Pires; de Oliveira, Maira Okada; Cassimiro, Luciana; Avolio, Isabella Maria Bello; Tres, Eduardo Sturzeneker; Borges, Conrado Regis; Teixeira, Thiago Bezerra Moraes; Brucki, Sonia Maria Dozzi] Univ Sao Paulo, Sch Med, Dept Neurol, Sao Paulo, Brazil.
   [Barbosa, Breno Jose Alencar Pires] Univ Fed Pernambuco, Ctr Ciencias Med, Area Acad Neuropsiquiatria, Recife, Brazil.
   [de Souza-Talarico, Juliana Nery; de Jesus, Maria Clara Ferreira] Univ Sao Paulo, Sch Nursing, Dept Med Surg Nursing, Sao Paulo, Brazil.
   [de Souza-Talarico, Juliana Nery] Univ Iowa, Coll Nursing, Iowa City, IA USA.
   [Mota, Gabriel Paz Souza] Univ Fed Juiz de Fora, Juiz De Fora, Brazil.
   [Barbosa, Breno Jose Alencar Pires] Univ Fed Pernambuco, Dept Fis, Hosp Clin, Ave Prof Moraes Rego 1235 Bloco A Terreo Cidade Un, BR-50670901 Recife, PE, Brazil.
C3 Universidade de Sao Paulo; Universidade Federal de Pernambuco;
   Universidade de Sao Paulo; University of Iowa; Universidade Federal de
   Juiz de Fora; Universidade Federal de Pernambuco
RP Barbosa, BJAP (corresponding author), FMUSP, Div Clin Neurol, Hosp Clin, Ave Dr Eneas De Carvalho Aguiar 255,5 Andar,Sala 5, BR-05403900 Sao Paulo, SP, Brazil.; Barbosa, BJAP (corresponding author), Univ Fed Pernambuco, Dept Fis, Hosp Clin, Ave Prof Moraes Rego 1235 Bloco A Terreo Cidade Un, BR-50670901 Recife, PE, Brazil.
EM breno.pbarbosa@ufpe.br; juliana-desouzatalarico@uiowa.edu;
   mariaclarajesus@usp.br; ga.paz.mota@gmail.com; maira.okada@gmail.com;
   lucassimiro@terra.com.br; isabella.avolio@hotmail.com;
   eduardotres.neuro@gmail.com; conradoborges@outlook.com;
   thiagobmteixeira@gmail.com; sonia.brucki@gmail.com
RI Maria Dozzi Brucki, Sonia/HKV-7483-2023; Talarico,
   Juliana/ABA-8650-2020; de Oliveira, Maira/P-1671-2019; Alencar Pires
   Barbosa, Breno Jose/J-6969-2013; Tres, Eduardo/D-3769-2015
OI Alencar Pires Barbosa, Breno Jose/0000-0003-4333-2024; Paz Souza Mota,
   Gabriel/0000-0002-6872-1432; Tres, Eduardo/0000-0002-6112-7190
FU FAPESP [2021/01459-3, 2012/50239- 6, 2017/10033-4]; Formas [2021-01459]
   Funding Source: Formas
FX This research is funded by the agency FAPESP (Grants 2012/50239- 6,
   2017/10033-4 and 2021/01459-3) .
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NR 60
TC 0
Z9 0
U1 5
U2 9
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0303-8467
EI 1872-6968
J9 CLIN NEUROL NEUROSUR
JI Clin. Neurol. Neurosurg.
PD AUG
PY 2024
VL 243
AR 108365
DI 10.1016/j.clineuro.2024.108365
EA JUN 2024
PG 7
WC Clinical Neurology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Surgery
GA XT0H7
UT WOS:001263806500001
PM 38852227
DA 2025-06-11
ER

PT J
AU Miraldi, ER
   Sharfi, H
   Friedline, RH
   Johnson, H
   Zhang, T
   Lau, KS
   Ko, HJ
   Curran, TG
   Haigis, KM
   Yaffe, MB
   Bonneau, R
   Lauffenburger, DA
   Kahn, BB
   Kim, JK
   Neel, BG
   Saghatelian, A
   White, FM
AF Miraldi, Emily R.
   Sharfi, Hadar
   Friedline, Randall H.
   Johnson, Hannah
   Zhang, Tejia
   Lau, Ken S.
   Ko, Hwi Jin
   Curran, Timothy G.
   Haigis, Kevin M.
   Yaffe, Michael B.
   Bonneau, Richard
   Lauffenburger, Douglas A.
   Kahn, Barbara B.
   Kim, Jason K.
   Neel, Benjamin G.
   Saghatelian, Alan
   White, Forest M.
TI Molecular network analysis of phosphotyrosine and lipid metabolism in
   hepatic PTP1b deletion mice
SO INTEGRATIVE BIOLOGY
LA English
DT Article
ID ENDOPLASMIC-RETICULUM STRESS; LEAST-SQUARES REGRESSION; LIVER-SPECIFIC
   DELETION; TYROSINE PHOSPHORYLATION; INSULIN SENSITIVITY;
   MASS-SPECTROMETRY; LIGAND-BINDING; FATTY LIVER; PROTEIN; OBESITY
AB Metabolic syndrome describes a set of obesity-related disorders that increase diabetes, cardiovascular, and mortality risk. Studies of liver-specific protein-tyrosine phosphatase 1b (PTP1b) deletion mice (L-PTP1b(-/-)) suggest that hepatic PTP1b inhibition would mitigate metabolic-syndrome through amelioration of hepatic insulin resistance, endoplasmic-reticulum stress, and whole-body lipid metabolism. However, the altered molecular-network states underlying these phenotypes are poorly understood. We used mass spectrometry to quantify protein-phosphotyrosine network changes in L-PTP1b(-/-) mouse livers relative to control mice on normal and high-fat diets. We applied a phosphosite-set-enrichment analysis to identify known and novel pathways exhibiting PTP1b- and diet-dependent phosphotyrosine regulation. Detection of a PTP1b-dependent, but functionally uncharacterized, set of phosphosites on lipid-metabolic proteins motivated global lipidomic analyses that revealed altered polyunsaturated-fatty-acid (PUFA) and triglyceride metabolism in L-PTP1b(-/-) mice. To connect phosphosites and lipid measurements in a unified model, we developed a multivariate-regression framework, which accounts for measurement noise and systematically missing proteomics data. This analysis resulted in quantitative models that predict roles for phosphoproteins involved in oxidation-reduction in altered PUFA and triglyceride metabolism.
C1 [Miraldi, Emily R.] MIT, Cambridge, MA 02138 USA.
   [Miraldi, Emily R.; Sharfi, Hadar; Johnson, Hannah; Lau, Ken S.; Curran, Timothy G.; Yaffe, Michael B.; White, Forest M.] MIT, Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA.
   [Friedline, Randall H.; Ko, Hwi Jin; Kim, Jason K.] Univ Massachusetts, Sch Med, Program Mol Med, Worcester, MA 01605 USA.
   [Friedline, Randall H.; Ko, Hwi Jin; Kim, Jason K.] Univ Massachusetts, Sch Med, Dept Med, Div Endocrinol Metab & Diabet, Worcester, MA 01605 USA.
   [Johnson, Hannah; Lau, Ken S.; Curran, Timothy G.; Lauffenburger, Douglas A.; White, Forest M.] MIT, Dept Biol Engn, Cambridge, MA 02139 USA.
   [Zhang, Tejia; Saghatelian, Alan] Harvard Univ, Dept Chem & Chem Biol, Cambridge, MA 02138 USA.
   [Lau, Ken S.; Haigis, Kevin M.] Massachusetts Gen Hosp, Ctr Canc Res, Mol Pathol Unit, Charlestown, MA 02129 USA.
   [Lau, Ken S.; Haigis, Kevin M.] Massachusetts Gen Hosp, Ctr Syst Biol, Charlestown, MA 02129 USA.
   [Haigis, Kevin M.] Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA.
   [Bonneau, Richard] NYU, Ctr Genom & Syst Biol, New York, NY 10003 USA.
   [Kahn, Barbara B.] Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Div Endocrinol Diabet & Metab,Dept Med, Boston, MA 02215 USA.
   [Neel, Benjamin G.] Univ Toronto, Dept Med Biophys, Toronto, ON M5G 2M9, Canada.
   [Neel, Benjamin G.] Univ Hlth Network, Ontario Canc Inst, Campbell Family Canc Res Inst, Toronto, ON M5G 1K7, Canada.
   [Neel, Benjamin G.] Univ Hlth Network, Princess Margaret Hosp, Toronto, ON M5G 1K7, Canada.
C3 Massachusetts Institute of Technology (MIT); Massachusetts Institute of
   Technology (MIT); University of Massachusetts System; University of
   Massachusetts Worcester; University of Massachusetts System; University
   of Massachusetts Worcester; Massachusetts Institute of Technology (MIT);
   Harvard University; Harvard University; Harvard University Medical
   Affiliates; Massachusetts General Hospital; Harvard University; Harvard
   University Medical Affiliates; Massachusetts General Hospital; Harvard
   University; Harvard Medical School; New York University; Harvard
   University; Harvard Medical School; Harvard University Medical
   Affiliates; Beth Israel Deaconess Medical Center; University of Toronto;
   University of Toronto; University Health Network Toronto; University of
   Toronto; University Health Network Toronto; Princess Margaret Cancer
   Centre
RP Miraldi, ER (corresponding author), MIT, Cambridge, MA 02138 USA.
EM fwhite@mit.edu
RI Lau, Ken/I-7958-2019; Bonneau, Richard/ABD-6737-2021
OI Reeves, Hannah/0000-0003-3473-3782; Lau, Ken/0000-0001-8438-0319; White,
   Forest/0000-0002-1545-1651; Kim, Jason/0000-0002-7185-042X
FU Pfizer Inc.; NIH [5R24DK090963, U54-CA112967, CA49152 R37,
   R01-DK080756]; UMass Mouse Metabolic Phenotyping Center Grant
   [U24-DK093000]; National Science Foundation; Ontario Ministry of Health
   and Long Term Care; Princess Margaret Hospital Foundation
FX We thank Ms Angel Sing (OCI) for generating the mice for this study,
   Edwin Homan (Harvard) for help with fatty acid separation techniques,
   Robert Gerszten (Mass General Hospital) for helpful advice, and Kristen
   Naegle (Washington University) for assistance with phosphosite
   annotations in PTMScout. This work was supported by a grant from Pfizer
   Inc., NIH grants 5R24DK090963, U54-CA112967, CA49152 R37 (B.G.N.), and
   R01-DK080756 (J.K.K.), and the UMass Mouse Metabolic Phenotyping Center
   Grant (U24-DK093000) (J.K.K.). E. R. M. has been supported by a Graduate
   Research Fellowship from the National Science Foundation. Work in
   B.G.N.'s lab is partially supported by the Ontario Ministry of Health
   and Long Term Care and the Princess Margaret Hospital Foundation.
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NR 59
TC 16
Z9 20
U1 0
U2 16
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1757-9694
EI 1757-9708
J9 INTEGR BIOL-UK
JI Integr. Biol.
PY 2013
VL 5
IS 7
BP 940
EP 963
DI 10.1039/c3ib40013a
PG 24
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA 170TP
UT WOS:000320877100003
PM 23685806
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Lim, S
   Quon, MJ
   Koh, KK
AF Lim, Soo
   Quon, Michael J.
   Koh, Kwang Kon
TI Modulation of adiponectin as a potential therapeutic strategy
SO ATHEROSCLEROSIS
LA English
DT Review
DE Adiponectin; Cardiovascular disease; Insulin resistance;
   Atherosclerosis; Obesity
ID HIGH-MOLECULAR-WEIGHT; CAUSES INSULIN-RESISTANCE;
   ACTIVATED-RECEPTOR-GAMMA; CORONARY-ARTERY-DISEASE; INCREASES
   PLASMA-LEVELS; ALL-CAUSE MORTALITY; ENDOTHELIAL FUNCTION; PPAR-GAMMA;
   OXIDATIVE STRESS; MYOCARDIAL-INFARCTION
AB Adiponectin is produced predominantly by adipocytes and plays an important role in metabolic and cardiovascular homeostasis through its insulin-sensitizing actions and anti-inflammatory and anti-atherogenic properties. Recently, it has been observed that lower levels of adiponectin can substantially increase the risk of developing type 2 diabetes, metabolic syndrome, atherosclerosis, and cardiovascular disease in patients who are obese. Circulating adiponectin levels are inversely related to the inflammatory process, oxidative stress, and metabolic dysregulation. Intensive lifestyle modifications and pharmacologic agents, including peroxisome proliferator-activated receptor-gamma or alpha agonists, some statins, renin-angiotensin-aldosterone system blockers, some calcium channel blockers, mineralocorticoid receptor blockers, new beta-blockers, and several natural compounds can increase adiponectin levels and suppress or prevent disease initiation or progression, respectively, in cardiovascular and metabolic disorders. Therefore, it is important for investigators to have a thorough understanding of the interventions that can modulate adiponectin. Such knowledge may lead to new therapeutic approaches for diseases such as type 2 diabetes, metabolic syndrome, cardiovascular disease, and obesity. This review focuses on recent updates regarding therapeutic interventions that might modulate adiponectin. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
C1 [Lim, Soo] Seoul Natl Univ, Bundang Hosp, Coll Med, Div Endocrinol, Songnam, South Korea.
   [Quon, Michael J.] Univ Maryland, Sch Med, Dept Med, Div Endocrinol Diabet & Nutr, Baltimore, MD 21201 USA.
   [Koh, Kwang Kon] Gachon Univ, Gil Med Ctr, Inchon 405760, South Korea.
   [Koh, Kwang Kon] Gachon Cardiovasc Res Inst, Inchon, South Korea.
C3 Seoul National University (SNU); University System of Maryland;
   University of Maryland Baltimore; Gachon University; Gachon University
RP Koh, KK (corresponding author), Gachon Univ, Gil Med Ctr, Vasc Med & Atherosclerosis Unit, 1198 Kuwol Dong, Inchon 405760, South Korea.
EM kwangk@gilhospital.com
RI Quon, Michael/B-1970-2008; Lim, Soo/AAU-8107-2020
OI Quon, Michael/0000-0002-9601-9915; Lim, Soo/0000-0002-4137-1671; QUON,
   MICHAEL/0000-0002-5289-3707
FU established investigator award; Gachon University Gil Hospital
FX This study was supported in part by grants from established investigator
   award (2012), Gachon University Gil Hospital (KKK).
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NR 87
TC 112
Z9 124
U1 2
U2 32
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0021-9150
EI 1879-1484
J9 ATHEROSCLEROSIS
JI Atherosclerosis
PD APR
PY 2014
VL 233
IS 2
BP 721
EP 728
DI 10.1016/j.atherosclerosis.2014.01.051
PG 8
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA AE9OM
UT WOS:000334337200062
PM 24603219
DA 2025-06-11
ER

PT J
AU Kobori, M
   Takahashi, Y
   Takeda, H
   Takahashi, M
   Izumi, Y
   Akimoto, Y
   Sakurai, M
   Oike, H
   Nakagawa, T
   Itoh, M
   Bamba, T
   Kimura, T
AF Kobori, Masuko
   Takahashi, Yumiko
   Takeda, Hiroaki
   Takahashi, Masatomo
   Izumi, Yoshihiro
   Akimoto, Yukari
   Sakurai, Mutsumi
   Oike, Hideaki
   Nakagawa, Toshiyuki
   Itoh, Masanori
   Bamba, Takeshi
   Kimura, Toshiyuki
TI Dietary Intake of Curcumin Improves eIF2 Signaling and Reduces Lipid
   Levels in the White Adipose Tissue of Obese Mice
SO SCIENTIFIC REPORTS
LA English
DT Article
ID ENDOPLASMIC-RETICULUM STRESS; CARDIOVASCULAR-DISEASE;
   INSULIN-RESISTANCE; GENE-EXPRESSION; PPAR-GAMMA; ER STRESS; LIPOLYSIS;
   METABOLITES; BINDING; ADIPOGENESIS
AB White adipose tissue (eWAT) plays a crucial role in preventing metabolic syndrome. We aimed to investigate WAT distribution and gene expression and lipidomic profiles in epididymal WAT (eWAT) in diet-induced obese mice, reflecting a Western-style diet of humans to elucidate the bioactive properties of the dietary antioxidant curcumin in preventing lifestyle-related diseases. For 16 weeks, we fed C57BL/6J mice with a control diet, a high-fat, high-sucrose and high-cholesterol Western diet or Western diet supplemented with 0.1% (w/w) curcumin. Although the dietary intake of curcumin did not affect eWAT weight or plasma lipid levels, it reduced lipid peroxidation markers' levels in eWAT. Curcumin accumulated in eWAT and changed gene expressions related to eukaryotic translation initiation factor 2 (eIF2) signalling. Curcumin suppressed eIF2 alpha phosphorylation, which is induced by endoplasmic reticulum (ER) stress, macrophage accumulation and nuclear factor-kappa B (NF-kappa B) p65 and leptin expression, whereas it's anti-inflammatory effect was inadequate to decrease TNF-alpha and IFN-gamma levels. Lipidomic and gene expression analysis revealed that curcumin decreased some diacylglycerols (DAGs) and DAG-derived glycerophospholipids levels by suppressing the glycerol-3-phosphate acyltransferase 1 and adipose triglyceride lipase expression, which are associated with lipogenesis and lipolysis, respectively. Presumably, these intertwined effects contribute to metabolic syndrome prevention by dietary modification.
C1 [Kobori, Masuko; Takahashi, Yumiko; Akimoto, Yukari; Sakurai, Mutsumi; Oike, Hideaki; Kimura, Toshiyuki] Natl Agr & Food Res Org, Food Res Inst, Tsukuba, Ibaraki 3058642, Japan.
   [Takeda, Hiroaki; Takahashi, Masatomo; Izumi, Yoshihiro; Bamba, Takeshi] Kyushu Univ, Med Inst Bioregulat, Fukuoka, Fukuoka 8128582, Japan.
   [Nakagawa, Toshiyuki; Itoh, Masanori] Gifu Univ, Grad Sch Med, Dept Neurobiol, Gifu, Gifu 5011194, Japan.
C3 National Agriculture & Food Research Organization - Japan; Kyushu
   University; Gifu University
RP Kobori, M (corresponding author), Natl Agr & Food Res Org, Food Res Inst, Tsukuba, Ibaraki 3058642, Japan.
EM kobori@affrc.go.jp
RI Takeda, Hiroaki/LTF-3416-2024; Bamba, Takeshi/KOD-6144-2024; Oike,
   Hideaki/C-6457-2009
OI Izumi, Yoshihiro/0000-0003-4608-4652; Takeda,
   Hiroaki/0000-0002-9299-4748; Oike, Hideaki/0000-0002-6139-5726; Bamba,
   Takeshi/0000-0002-7442-2738; Nakagawa, Toshiyuki/0000-0001-8415-4119
FU Ministry of Agriculture, Forestry and Fisheries (MAFF); Research Project
   on Development of Agricultural Products and Foods with Health-Promoting
   Benefits, National Agriculture and Food Research Organization (NARO);
   Ministry of Education, Culture, Sports, Science and Technology, Japan
   [15K00867]; Uragami Foundation; Advanced low carbon technology research
   and development program (ALCA) of the Japan Science and Technolocy
   Agency (JST); Japan Agency for Medical Research and Development (AMED);
   Creation of Innovative Technology for Medical Applications Based on the
   Global Analyses and Regulation of Disease-Related Metabolites Project of
   the AMED [JPMJCR1395]; Grants-in-Aid for Scientific Research [15K00867]
   Funding Source: KAKEN
FX This work was financially supported in part by a grant from a Ministry
   of Agriculture, Forestry and Fisheries (MAFF) research project for the
   special scheme to deploy highly advanced technology for agriculture,
   forestry, and fisheries (to M.K. and T.B.), a grant from the Research
   Project on Development of Agricultural Products and Foods with
   Health-Promoting Benefits, National Agriculture and Food Research
   Organization (NARO) (to M.K.), Ministry of Education, Culture, Sports,
   Science and Technology, Japan (15K00867 to M.K.), the Uragami Foundation
   (to M.K.), a grant from the Advanced low carbon technology research and
   development program (ALCA) of the Japan Science and Technolocy Agency
   (JST) (to Y.I. and T.B.), a grant from the Studies on Specific
   Activities and Functions of Lipid Molecules to Develop Innovative
   Medical Technologies Project of the Japan Agency for Medical Research
   and Development (AMED) (to Y.I. and T.B.), and a grant from the Creation
   of Innovative Technology for Medical Applications Based on the Global
   Analyses and Regulation of Disease-Related Metabolites Project
   (JPMJCR1395) of the AMED (to T.B.). We thank Dr. Hiroshi Ono and Ms.
   Tomoko Sato for performing the UHPLC-ESI-Q-Orbitrap-MS analysis at
   Advanced Analysis Center, NARO. We thank Dr. Ohnishi-Kameyama (Food
   Research Institute, NARO), for valuable advice. We thank Enago (Crimson
   Interactive Japan, Tokyo, Japan) for the English language review.
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NR 55
TC 28
Z9 29
U1 2
U2 11
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD JUN 13
PY 2018
VL 8
AR 9081
DI 10.1038/s41598-018-27105-w
PG 13
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA GJ2CT
UT WOS:000435077300024
PM 29899429
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Du, X
   Liu, ZY
   Tao, XX
   Mei, YL
   Zhou, DQ
   Cheng, K
   Gao, SL
   Shi, HY
   Song, C
   Zhang, XM
AF Du, Xin
   Liu, Zi-yu
   Tao, Xing-xing
   Mei, Yong-liang
   Zhou, Da-qian
   Cheng, Kang
   Gao, Si-long
   Shi, Hou-yin
   Song, Chao
   Zhang, Xiao-min
TI Research Progress on the Pathogenesis of Knee Osteoarthritis
SO ORTHOPAEDIC SURGERY
LA English
DT Review
DE Bone Metabolism; Cytokines; Inflammation; Knee Osteoarthritis; Long
   Non-Coding RNA
ID NECROSIS-FACTOR-ALPHA; NF-KAPPA-B; SYMPTOMATIC KNEE; EXPRESSION;
   INFLAMMATION; OBESITY; ASSOCIATION; PREVALENCE; BIOMARKERS; COLLAGEN
AB Knee osteoarthritis (KOA) is a chronic joint bone disease characterized by inflammatory destruction and hyperplasia of bone. Its main clinical symptoms are joint mobility difficulties and pain, severe cases can lead to limb paralysis, which poses major pressure to the quality of life and mental health of patients, but also brings serious economic burden to society. The occurrence and development of KOA is influenced by many factors, including systemic factors and local factors. The joint biomechanical changes caused by aging, trauma and obesity, abnormal bone metabolism caused by metabolic syndrome, the effects of cytokines and related enzymes, genetic and biochemical abnormalities caused by plasma adiponectin, etc. all directly or indirectly lead to the occurrence of KOA. However, there is little literature that systematically and comprehensively integrates macro- and microscopic KOA pathogenesis. Therefore, it is necessary to comprehensively and systematically summarize the pathogenesis of KOA in order to provide a better theoretical basis for clinical treatment.
C1 [Du, Xin; Liu, Zi-yu; Tao, Xing-xing] Southwest Med Univ, Affiliated Hosp Tradit Chinese Med, Ctr Phenom Tradit Chinese Med, Luzhou, Peoples R China.
   [Mei, Yong-liang; Zhou, Da-qian; Cheng, Kang; Gao, Si-long; Song, Chao; Zhang, Xiao-min] Southwest Med Univ, Affiliated Hosp Tradit Chinese Med, Dept Orthopaed & Traumatol Trauma & Bone Setting, Luzhou, Sichuan, Peoples R China.
   [Shi, Hou-yin] Southwest Med Univ, Affiliated Hosp Tradit Chinese Med, Med Dept, Luzhou, Peoples R China.
C3 Southwest Medical University; Southwest Medical University; Southwest
   Medical University
RP Zhang, XM (corresponding author), Southwest Med Univ, Affiliated Hosp Tradit Chinese Med, Dept Orthopaed & Traumatol Trauma & Bone Setting, Luzhou, Sichuan, Peoples R China.
EM 243087898@qq.com
RI Song, Chao/KVY-3360-2024; Zhang, Xiaomin/O-5144-2015
OI Song, Chao/0000-0003-0611-4298; Du, Xin/0000-0003-2288-5770
FU Key R amp; D Projects of Sichuan Science and Technology Department
   [2022YFS0609]; Luzhou Science and Technology Project [2022-SYF-88]
FX Acknowledgement This work was supported by Key R & D Projects of Sichuan
   Science and Technology Department (Grant number: 2022YFS0609) and Luzhou
   Science and Technology Project (Grant number: 2022-SYF-88).
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NR 79
TC 54
Z9 61
U1 20
U2 58
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1757-7853
EI 1757-7861
J9 ORTHOP SURG
JI Orthop. Surg.
PD SEP
PY 2023
VL 15
IS 9
BP 2213
EP 2224
DI 10.1111/os.13809
EA JUL 2023
PG 12
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA R0JS5
UT WOS:001024266400001
PM 37435789
OA Green Published, gold
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Sabry, K
   Jamshidi, Z
   Emami, SA
   Sahebkar, A
   Akaberi, M
AF Sabry, Kamyar
   Jamshidi, Zahra
   Emami, Seyed Ahmad
   Sahebkar, Amirhossein
   Akaberi, Maryam
TI Potential therapeutic effects of baicalin and baicalein
SO AVICENNA JOURNAL OF PHYTOMEDICINE
LA English
DT Review
DE Hepatoprotective; Metabolic syndrome; Neuroprotective
ID MIGRATION INHIBITORY FACTOR; COLLAGEN-INDUCED ARTHRITIS; ACTIVATED
   PROTEIN-KINASE; NF-KAPPA-B; IN-VITRO; ADIPOCYTE DIFFERENTIATION;
   ISCHEMIA/REPERFUSION INJURY; INTRACEREBRAL HEMORRHAGE;
   LIQUID-CHROMATOGRAPHY; OXIDATIVE STRESS
AB Objective: Baicalin and baicalein are natural flavonoids reported for the first time from Scutellaria baicalensis Georgi. Recently, attention has been paid to these valuable flavonoids due to their promising effects. This paper aims to have a comprehensive review of their pharmacological effects.Materials and Methods: An extensive search through scientific databases including Scopus, PubMed, and ISI Web of Science was established.Results: According to literature, these compounds have been mainly effective in the treatment of neurological and neurodegenerative diseases, hepatic and cardiovascular disorders, metabolic syndrome, and cancers through anti-inflammatory and antioxidant pathways. Induction of apoptosis and autophagy, and inhibition of migration and metastasis are the main mechanisms for their cytotoxic and antitumor activities. Decreasing inflammation, reducing oxidative stress, regulating the metabolism of lipids, and decreasing fibrosis, apoptosis, and steatosis are their main hepatoprotective mechanisms. Inhibiting the development of cardiac fibrosis and reducing inflammation, oxidative stress, and apoptosis are also the mechanisms suggested for cardioprotective activities. Decreasing the accumulation of inflammatory mediators and improving cognitive function and depressive-like behaviours are the main mechanisms for neurological and neurodegenerative activities.Conclusion: The findings suggest the therapeutic potential of baicalin and baicalein. However, complementary research in different in vitro and in vivo models to investigate their mechanisms of action as well as clinical trials to evaluate their efficacy and safety are suggested.
C1 [Sabry, Kamyar; Akaberi, Maryam] Mashhad Univ Med Sci, Sch Pharm, Dept Pharmacognosy, Mashhad, Iran.
   [Jamshidi, Zahra] Mashhad Univ Med Sci, Sch Pharm, Dept Med Chem, Mashhad, Iran.
   [Emami, Seyed Ahmad] Mashhad Univ Med Sci, Sch Pharm, Dept Tradit Pharm, Mashhad, Iran.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Appl Biomed Res Ctr, Mashhad, Iran.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Biotechnol Res Ctr, Mashhad, Iran.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Sch Pharm, Dept Biotechnol, Mashhad, Iran.
C3 Mashhad University of Medical Sciences; Mashhad University of Medical
   Sciences; Mashhad University of Medical Sciences; Mashhad University of
   Medical Sciences; Mashhad University of Medical Sciences; Mashhad
   University of Medical Sciences
RP Akaberi, M (corresponding author), Mashhad Univ Med Sci, Sch Pharm, Dept Pharmacognosy, Mashhad, Iran.; Sahebkar, A (corresponding author), Mashhad Univ Med Sci, Appl Biomed Res Ctr, Mashhad, Iran.; Sahebkar, A (corresponding author), Mashhad Univ Med Sci, Pharmaceut Technol Inst, Biotechnol Res Ctr, Mashhad, Iran.; Sahebkar, A (corresponding author), Mashhad Univ Med Sci, Sch Pharm, Dept Biotechnol, Mashhad, Iran.
EM amir_saheb2000@yahoo.com; akaberim@mums.ac.ir
RI Akaberi, Maryam/AAS-9054-2020; Sahebkar, Amirhossein/B-5124-2018; Emami,
   Seyed Ahmad/IZE-9039-2023; jamshidi, zahra/HGE-8146-2022
FU Mashhad University of Medical Sciences
FX The authors would like to thank Mashhad University of Medical Sciences
   (MUMS) for their help and support.
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NR 185
TC 7
Z9 7
U1 6
U2 17
PU MASHHAD UNIV MED SCIENCES
PI MASHHAD
PA VICE-CHANCELLOR FOR RES CTR OFF IJBMS, DANESHGAH ST, PO BOX 9138813944 -
   445, MASHHAD, 00000, IRAN
SN 2228-7930
EI 2228-7949
J9 AVICENNA J PHYTOMEDI
JI Avicenna J. Phytomedicine
PD JAN-FEB
PY 2024
VL 14
IS 1
BP 23
EP 49
DI 10.22038/AJP.2023.22307
PG 27
WC Chemistry, Medicinal
WE Emerging Sources Citation Index (ESCI)
SC Pharmacology & Pharmacy
GA CK9P2
UT WOS:001125266500010
PM 38948180
DA 2025-06-11
ER

PT J
AU Zhang, CY
   Li, H
   Wang, SX
AF Zhang, Chengyu
   Li, Han
   Wang, Shixiang
TI Common gene signatures and molecular mechanisms of diabetic nephropathy
   and metabolic syndrome
SO FRONTIERS IN PUBLIC HEALTH
LA English
DT Article
DE transcription data; single-cell analysis; type 2 diabetes; oxidative
   phosphorylation; diabetic nephropathy
ID OXIDATIVE STRESS; KIDNEY-DISEASE; COMPLICATIONS; SUBSETS
AB BackgroundDiabetic nephropathy (DN) is the leading cause of end-stage renal disease. Multiple metabolic toxicities, redox stress, and endothelial dysfunction contribute to the development of diabetic glomerulosclerosis and DN. Metabolic syndrome (MetS) is a pathological state in which the body's ability to process carbohydrates, fats, and proteins is compromised because of metabolic disorders, resulting in redox stress and renal remodeling. However, a causal relationship between MetS and DN has not been proven. This study aimed to provide valuable information for the clinical diagnosis and treatment of MetS with DN. MethodsHere, transcriptome data of DN and MetS patients were obtained from the Gene Expression Omnibus database, and seven potential biomarkers were screened using bioinformatics analysis. In addition, the relationship between these marker genes and metabolism and immune infiltration was explored. Among the identified marker genes, the relationship between PLEKHA1 and the cellular process, oxidative phosphorylation (OXPHOS), in DN was further investigated through single-cell analysis. ResultsWe found that PLEKHA1 may represent an important biomarker that perhaps initiates DN by activating B cells, proximal tubular cells, distal tubular cells, macrophages, and endothelial cells, thereby inducing OXPHOS in renal monocytes. ConclusionOverall, our findings can aid in further investigation of the effects of drug treatment on single cells of patients with diabetes to validate PLEKHA1 as a therapeutic target and to inform the development of targeted therapies.
C1 [Zhang, Chengyu; Li, Han; Wang, Shixiang] Capital Med Univ, Beijing Chao Yang Hosp, Dept Nephrol, Beijing, Peoples R China.
C3 Capital Medical University
RP Li, H (corresponding author), Capital Med Univ, Beijing Chao Yang Hosp, Dept Nephrol, Beijing, Peoples R China.
EM hanli@ccmu.edu.cn
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NR 45
TC 7
Z9 8
U1 2
U2 5
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 2296-2565
J9 FRONT PUBLIC HEALTH
JI Front. Public Health
PD MAR 30
PY 2023
VL 11
AR 1150122
DI 10.3389/fpubh.2023.1150122
PG 13
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA D3YW9
UT WOS:000968129200001
PM 37143982
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Guerrero-Romero, F
   Rodríguez-Morán, M
AF Guerrero-Romero, Fernando
   Rodriguez-Moran, Martha
TI Hypomagnesemia, oxidative stress, inflammation, and metabotic syndrome
SO DIABETES-METABOLISM RESEARCH AND REVIEWS
LA English
DT Article
DE metabolic syndrome; inflammation; hypomagnesemia; oxidative stress;
   C-reactive protein; malondialdehyde
ID C-REACTIVE PROTEIN; SERUM MAGNESIUM LEVELS; LIPID-PEROXIDATION; DIETARY
   MAGNESIUM; CALCIUM; INTERLEUKIN-6; CHOLESTEROL; DISEASE; ALPHA
AB Background Although hypomagnesemia, oxidative stress, and inflammation are involved in the pathogenesis of cardiovascular diseases, there is not a previous description concerning their potential interaction; thus, the aim of this study was to examine the relationship between metabolic syndrome (MetS), hypomagnesemia, inflammation, and oxidative stress.
   Methods Case-control design study. incident cases of MetS (84 women and 63 men) were compared with healthy control subjects (163 women and 131 men) matched by age and gender. MetS was diagnosed according to the Adult Treatment Panel III (ATP III) criterion. Oxidative stress was defined by serum malondialdehyde concentration (MDA) >= 50 mg/dL, low-grade chronic inflammation by C-reactive protein (CRP) serum levels >= 3 mg/L, and hypomagnesemia by serum magnesium concentrations <= 1.8 mg/dL.
   Results Multivariate analysis adjusted by age, sex, body mass index, waist-to-hip ratio, and total adiposity showed a strong association between MetS and hypomagnesemia (OR 1.9; 95% CI 1.3-7.1), inflammation (OR 1.7; 95% CI 1.4-8-4), and oxidative stress (OR 1.4; 95% CI 0.9-12.6). Additional adjustment by CRP levels showed that MetS remained associated to hypomagnesemia (OR 1.4; 95% CI 1.1-5.9) but not to oxidative stress (OR 1.1; 95% CI 0.9-5.9), and adjusted by MDA levels, MetS remained strongly associated to hypomagnesemia (1.6; CI 95% 1.1-7.4), but not to inflammation (OR 1.05; 95% CI 0.97-14.2). Adjusted by serum magnesium levels, inflammation (OR 1.2; 95% CI 1.1-9.1) and oxidative stress (OR 1.1; 95% CI 1.1-9-7) were slightly associated to MetS.
   Conclusions The interaction of inflammation and oxidative stress is related and increases the risk for MetS, whereas serum magnesium levels and MetS are independently associated. Copyright (c) 2006 John Wiley & Sons, Ltd.
C1 Mexican Social Secur Inst, Med Res Unit Clin Epidemiol, Res Grp Diabet & Chron Illnesses, Durango, Dgo, Mexico.
C3 Instituto Mexicano del Seguro Social
RP Guerrero-Romero, F (corresponding author), Siqueiros 225 Esq Castaneda, Durango 34000, Dgo, Mexico.
EM guerrero_romero@hotmail.com
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NR 43
TC 126
Z9 132
U1 0
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1520-7552
EI 1520-7560
J9 DIABETES-METAB RES
JI Diabetes-Metab. Res. Rev.
PD NOV-DEC
PY 2006
VL 22
IS 6
BP 471
EP 476
DI 10.1002/dmrr.644
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 110BX
UT WOS:000242354400006
PM 16598698
OA Bronze
DA 2025-06-11
ER

PT J
AU García-Carrasco, A
   Izquierdo-Lahuerta, A
   Medina-Gómez, G
AF Garcia-Carrasco, Almudena
   Izquierdo-Lahuerta, Adriana
   Medina-Gomez, Gema
TI The Kidney-Heart Connection in Obesity
SO NEPHRON
LA English
DT Review
DE Obesity; Cardiorenal metabolic syndrome; Kidney; Heart; Endothelium
   hemodynamic changes
AB There is a strong relationship between the kidney and the heart, where if one of these organs fails, so does the other, in the so-called cardiorenal syndrome (CRS). Besides, there are also interactions with the rest of the body leading to a metabolic state that establishes a feedback loop that is perpetuated. The CRS is characterized by hemodynamic changes, activation of neuro-humoral systems, natriuretic peptides, and changes in mineral metabolism. In this scenario, the kidney and heart, connected by a dysfunctional endothelium, inevitably fail. In obesity, this syndrome is exacerbated due to the complications of adipose tissue dysfunction, in the so-called cardiorenal metabolic syndrome (CRMetS). Obesity promotes adipose tissue dysfunction because it exceeds lipid storage capacity and leads to a lipotoxic state, characterized by inflammation, hypertension, insulin resistance and dyslipidemia, oxidative stress, and hyperuricemia, among others, that affect different organs other than the adipose tissue. In addition, the pro-inflammatory gut microbiota present in obese patients releases uremic toxins, contributing to oxidative stress and inflammation, perpetuating and accelerating the progression of this pathology. In this article, we describe the contribution of obesity, the factors and mechanisms implicated in the development of the CRMetS. Despite the great knowledge about the CRS, more research is needed to characterize the CRMetS given the global obesity epidemic.
C1 [Garcia-Carrasco, Almudena; Izquierdo-Lahuerta, Adriana; Medina-Gomez, Gema] Univ Rey Juan Carlos, Fac Ciencias Salud, Dept Ciencias Basicas Salud, Area Bioquim & Biol Mol, Madrid, Spain.
C3 Universidad Rey Juan Carlos
RP Izquierdo-Lahuerta, A; Medina-Gómez, G (corresponding author), Univ Rey Juan Carlos, Fac Ciencias Salud, Dept Ciencias Basicas Salud, Area Bioquim & Biol Mol, Madrid, Spain.
EM adriana.izquierdo@urjc.es; gema.medina@urjc.es
RI GarciaCarrasco, Almudena/LNQ-2317-2024; Medina-Gomez, Gema/F-5667-2016
OI Garcia Carrasco, Almudena/0000-0002-5679-3797
FU Ministerio de Economia y Competitividad de Espana [BFU201678951-R,
   BFU2017-90578-REDT]; Comunidad de Madrid (Spain) [B2017/BMD-3684]
FX Research conducted for this publication was supported by Ministerio de
   Economia y Competitividad de Espana (BFU201678951-R,
   BFU2017-90578-REDT), Comunidad de Madrid (Spain) (B2017/BMD-3684), to
   G.M.G.
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NR 15
TC 10
Z9 10
U1 0
U2 7
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1660-8151
EI 2235-3186
J9 NEPHRON
JI Nephron
PD NOV
PY 2021
VL 145
IS 6
BP 604
EP 608
DI 10.1159/000515419
EA APR 2021
PG 5
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA YZ1ZP
UT WOS:000640282800001
PM 33849028
DA 2025-06-11
ER

PT J
AU Abildgaard, A
   Lund, S
   Hougaard, KS
AF Abildgaard, Anders
   Lund, Sten
   Hougaard, Karin S.
TI Chronic high-fat diet increases acute neuroendocrine stress response
   independently of prenatal dexamethasone treatment in male rats
SO ACTA NEUROPSYCHIATRICA
LA English
DT Article
DE depressive disorder; diet; high-fat; IUGR; model; animals; stress;
   physiological
ID ADRENAL AXIS ACTIVITY; INTRAUTERINE GROWTH RESTRICTION; CATCH-UP GROWTH;
   GLUCOCORTICOID EXPOSURE; PREPULSE INHIBITION; GLUCOSE-INTOLERANCE;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; LATE-GESTATION; BIRTH-WEIGHT
AB Objective Intrauterine growth restriction (IUGR) has been associated with metabolic disorders later in life such as obesity and diabetes as well as psychiatric disorders such as depression and schizophrenia. Therefore, we wanted to investigate whether behavioural, metabolic or neuroendocrine abnormalities could be provoked or exacerbated by a high-fat diet (HFD) in an experimental model of IUGR.
   Methods Pregnant dams were exposed to dexamethasone (DEX) in the third gestational week to induce IUGR. Late adolescent male offspring of DEX- and vehicle-treated dams were then fed a HFD or standard chow for 8 weeks and subjected to a variety of assessments.
   Results Only diet affected the hypothalamus-pituitary-adrenal (HPA) axis stress response, as HFD doubled the observed corticosterone levels following acute restraint. HFD and prenatal DEX exposure concomitantly exacerbated depressive-like behaviour in the forced swim test, even though no interaction was seen. Prenatal DEX treatment tended to increase the basal acoustic startle response (ASR), while an interaction between HFD and DEX was present in the ASR pre-pulse inhibition suggestive of fundamental changes in neuronal gating mechanisms. Metabolic parameters were only affected by diet, as HFD increased fasting glucose and insulin levels.
   Conclusion We conclude that chronic HFD may be more important in programming of the HPA axis stress responsiveness than an adverse foetal environment and therefore potentially implies an increased risk for developing psychiatric and metabolic disease.
C1 [Abildgaard, Anders] Aarhus Univ, Translat Neuropsychiat Unit, Risskov, Denmark.
   [Lund, Sten] Aarhus Univ Hosp, Med Dept MEA Endocrinol, DK-8240 Risskov, Denmark.
   [Hougaard, Karin S.] Natl Res Ctr Working Environm, Copenhagen, Denmark.
C3 Aarhus University; Aarhus University; National Research Centre for the
   Working Environment
RP Abildgaard, A (corresponding author), Aarhus Univ Hosp, Translat Neuropsychiat Unit, Skovagervej 2, DK-8240 Risskov, Denmark.
EM anders@dadlnet.dk
RI Abildgaard, Anders/H-2869-2019; Hougaard, Karin Sorig/F-3606-2014
OI Lund, Sten/0000-0002-3805-6267; Hougaard, Karin
   Sorig/0000-0002-3386-0512; Abildgaard, Anders/0000-0001-7272-0953
FU Danish Council for Independent Research (Medical Sciences); Health
   Research Fund of Central Denmark Region; Augustinus Fonden; Aase og
   Ejnar Danielsens Fond; National Research Centre for the Working
   Environment
FX AA was supported by The Danish Council for Independent Research (Medical
   Sciences) and the Health Research Fund of Central Denmark Region. S. L.
   was supported by 'Augustinus Fonden' and 'Aase og Ejnar Danielsens
   Fond'. K. S. H. was supported by the National Research Centre for the
   Working Environment.
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NR 59
TC 21
Z9 21
U1 0
U2 11
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
SN 1601-5215
J9 ACTA NEUROPSYCHIATR
JI Acta Neuropsychiatr.
PD FEB
PY 2014
VL 26
IS 1
BP 8
EP 18
DI 10.1017/neu.2013.28
PG 11
WC Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Psychiatry
GA AA8SZ
UT WOS:000331366500003
PM 25142095
DA 2025-06-11
ER

PT J
AU Pan, MH
   Lai, CS
   Tsai, ML
   Ho, CT
AF Pan, Min-Hsiung
   Lai, Ching-Shu
   Tsai, Mei-Ling
   Ho, Chi-Tang
TI Chemoprevention of nonalcoholic fatty liver disease by dietary natural
   compounds
SO MOLECULAR NUTRITION & FOOD RESEARCH
LA English
DT Review
DE Chemoprevention; Nonalcoholic fatty liver disease; Dietary natural
   compounds
ID ENDOPLASMIC-RETICULUM STRESS; NECROSIS-FACTOR-ALPHA; MITOCHONDRIAL
   RESPIRATORY-CHAIN; INDUCED INSULIN-RESISTANCE; HEPATIC STELLATE CELLS;
   CIRCULATING INTERLEUKIN-6 LEVELS; INDUCED METABOLIC SYNDROME;
   EICOSAPENTAENOIC ACID EPA; HORMONE-SENSITIVE LIPASE; VISCERAL
   ADIPOSE-TISSUE
AB Nonalcoholic fatty liver disease (NAFLD) refers to a wide spectrum of liver disease that is not from excess alcohol consumption, but is often associated with obesity, type 2 diabetes, and metabolic syndrome. NAFLD pathogenesis is complicated and involves oxidative stress, lipotoxicity, mitochondrial damage, insulin resistance, inflammation, and excessive dietary fat intake, which increase hepatic lipid influx and de novo lipogenesis and impair insulin signaling, thus promoting hepatic triglyceride accumulation and ultimately NAFLD. Overproduction of proinflammatory adipokines from adipose tissue also affects hepatic metabolic function. Current NAFLD therapies are limited; thus, much attention has been focused on identification of potential dietary substances from fruits, vegetables, and edible plants to provide a new strategy for NAFLD treatment. Dietary natural compounds, such as carotenoids, omega-3-PUFAs, flavonoids, isothiocyanates, terpenoids, curcumin, and resveratrol, act through a variety of mechanisms to prevent and improve NAFLD. Here, we summarize and briefly discuss the currently known targets and signaling pathways as well as the role of dietary natural compounds that interfere with NAFLD pathogenesis.
C1 [Pan, Min-Hsiung; Lai, Ching-Shu] Natl Taiwan Univ, Inst Food Sci & Technol, Taipei 10617, Taiwan.
   [Pan, Min-Hsiung] China Med Univ, China Med Univ Hosp, Dept Med Res, Taichung, Taiwan.
   [Tsai, Mei-Ling] Natl Kaohsiung Marine Univ, Dept Seafood Sci, Kaohsiung, Taiwan.
   [Ho, Chi-Tang] Rutgers State Univ, Dept Food Sci, New Brunswick, NJ 08903 USA.
C3 National Taiwan University; China Medical University Taiwan; China
   Medical University Hospital - Taiwan; National Kaohsiung University of
   Science & Technology; Rutgers University System; Rutgers University New
   Brunswick
RP Pan, MH (corresponding author), Natl Taiwan Univ, Inst Food Sci & Technol, 1,Sect 4,Roosevelt Rd, Taipei 10617, Taiwan.
EM mhpan@ntu.edu.tw
RI Pan, Min-Hsiung/AAT-8865-2021; Ho, Chi-Tang/B-5629-2012
OI Pan, Min-Hsiung/0000-0002-5188-7030
FU National Science Council [NSC 101-2628-B-022-001-MY4,
   102-2628-B-002-053-MY3]
FX This study was supported by the National Science Council NSC
   101-2628-B-022-001-MY4, 102-2628-B-002-053-MY3.
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NR 254
TC 80
Z9 95
U1 0
U2 72
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1613-4125
EI 1613-4133
J9 MOL NUTR FOOD RES
JI Mol. Nutr. Food Res.
PD JAN
PY 2014
VL 58
IS 1
BP 147
EP 171
DI 10.1002/mnfr.201300522
PG 25
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA 302GI
UT WOS:000330590100013
PM 24302567
DA 2025-06-11
ER

PT J
AU Cheung, O
   Sanyal, AJ
AF Cheung, Onpan
   Sanyal, Arun J.
TI Recent advances in nonalcoholic fatty liver disease
SO CURRENT OPINION IN GASTROENTEROLOGY
LA English
DT Article
DE insulin resistance; lipid metabolism; metabolic syndrome; nonalcoholic
   steatohepatitis; oxidative stress
ID INTIMA-MEDIA THICKNESS; HEPATOCELLULAR-CARCINOMA; MICRORNA EXPRESSION;
   METABOLIC SYNDROME; CHOLINE-DEFICIENT; WEIGHT-LOSS; STEATOHEPATITIS;
   DIET; FIBROSIS; ACID
AB Purpose of review
   This review focuses on recent advances in the study of the epidemiology, pathogenesis, natural history and treatment of nonalcoholic fatty liver disease (NAFLD).
   Recent findings
   Study of hepatic lipid metabolism, insulin resistance, mitochondrial dysfunction and oxidative stress, genetic variants and predisposition to altered metabolism and cell injury have contributed to our current understanding of NAFLD. Differential expression of microRNA in fatty liver and its implication in disease pathogenesis and therapeutic potential have continued to advance over the year. The pathogenesis of hepatocellular carcinoma in steatohepatitis continues to be explored. The diagnostic utility of imaging and noninvasive markers seems promising in estimating the severity of steatosis and fibrosis. Liver biopsy remains the gold standard for accurately assessing NAFLD and steatohepatitis. Lifestyle modification and weight loss improve both metabolic profile and liver histology. Pharmacotherapy for the treatment of NAFLD remains lacking.
   Summary
   The underlying mechanism and pathogenesis of NAFLD remain elusive despite ongoing researches to make significant advances in the understanding of its natural history, pathogenesis and management. Pharmacotherapy has yet to indicate a promising therapeutic intervention. Current treatment focuses on managing underlying cardio-metabolic risks.
C1 [Cheung, Onpan; Sanyal, Arun J.] Virginia Commonwealth Univ, Med Ctr, Dept Internal Med, Div Gastroenterol Hepatol & Nutr, Richmond, VA USA.
C3 Virginia Commonwealth University
RP Sanyal, AJ (corresponding author), MCV Box 980341, Richmond, VA 23298 USA.
EM ajsanyal@hsc.vcu.edu
FU National Institutes of Health [K24 DK 02755-07]
FX The work was supported in part by a grant from the National Institutes
   of Health to Dr Sanyal K24 DK 02755-07.
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NR 79
TC 119
Z9 132
U1 0
U2 22
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0267-1379
EI 1531-7056
J9 CURR OPIN GASTROEN
JI Curr. Opin. Gastroenterol.
PD MAY
PY 2010
VL 26
IS 3
BP 202
EP 208
DI 10.1097/MOG.0b013e328337b0c4
PG 7
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 592LK
UT WOS:000277380200003
PM 20168226
DA 2025-06-11
ER

PT J
AU Zheng, YX
   Wang, X
   Wang, JY
   Yang, J
   Wang, T
   Li, Q
   Zhu, WZ
   Wang, Y
   Sui, J
   Qiang, W
   Guo, H
   Wang, YA
   Shi, BY
   He, MQ
AF Zheng, Yixuan
   Wang, Xin
   Wang, Jingya
   Yang, Jing
   Wang, Ting
   Li, Qian
   Zhu, Wenzhi
   Wang, Yue
   Sui, Jing
   Qiang, Wei
   Guo, Hui
   Wang, Yanan
   Shi, Bingyin
   He, Mingqian
TI Effects of time-restricted eating and low-carbohydrate diet on
   psychosocial health and appetite in individuals with metabolic syndrome:
   A secondary analysis of a randomized controlled trial
SO CLINICAL NUTRITION
LA English
DT Article
DE Metabolic syndrome; Time-restricted eating; Low-carbohydrate diet;
   Quality of life; Metabolic hormones
ID QUALITY-OF-LIFE; LOW-FAT DIET; WEIGHT-LOSS; REDUCES APPETITE;
   UNITED-STATES; VERY-LOW; OBESITY; PREVALENCE; SATIETY; ADULTS
AB Background & aims: Time-restricted eating (TRE) and low-carbohydrate diet (LCD) can improve multiple cardiometabolic parameters in patients with metabolic syndrome (MetS), but their effects on psychosocial health and satiety are unclear. In this study, we aimed to evaluate the effects of TRE, LCD, and their combination (TRE + LCD) on quality of life (QoL), sleep, mood, appetite, and metabolic hormones in patients with MetS. Methods: This is a secondary analysis of a single-center, 3-month, open-label, randomized clinical trial investigating the effects of TRE, LCD, and TRE + LCD on weight and cardiometabolic parameters in individuals with MetS. This secondary analysis examined QoL, sleep, mood, and appetite using the Rand 36-Item Short Form (SF-36); Pittsburgh Sleep Quality Index (PSQI); Depression, Anxiety, and Stress Scale; and Eating Behavior Rating Scale, respectively, as well as measured levels of metabolic hormones including leptin, amylin, glucose-dependent insulinotropic polypeptide, glucagon-like peptide-1 (GLP-1), pancreatic polypeptide (PP), and peptide YY. Between-group comparisons were conducted via one-way ANOVAs and post hoc LSD tests for normally distributed variables or Kruskal-Wallis H tests and the Nemenyi test for abnormally distributed variables. P < 0.017 was considered significant in multiple comparisons following Bonferroni adjustment. Results: A total of 162 participants (mean [SD] age, 41.2 [9.9] years; mean [SD] body mass index, 29.3 [3.4] kg/m(2); 102 [63%] men) who started the intervention were analyzed. After 3 months, only the TRE group decreased GLP-1 levels (-0.9 [IQR, -1.9 to -0.3] pg/mL; P = 0.002), increased PP levels (8.9 [IQR, -7.6 to 71.8] pg/mL; P = 0.011), physical functioning in the SF-36 (5.2 [95% CI, 1.9 to 8.5]; P = 0.001), social functioning in the SF-36 (9.1 [95% CI, 2.5 to 15.6]; P = 0.005), role-physical in the SF-36 (24.1 [95% CI, 11.8 to 36.4]; P < 0.001), role-emotional in the SF-36 (22.4 [95% CI, 12.6 to 32.2]; P < 0.001), and sleep efficiency in the PSQI (0.29 [95% CI, 0.03 to 0.55]; P = 0.021). Compared with changes in LCD, TRE further increased general health in the SF-36 (9.7 [95% CI, 3.3 to 16.0]; P = 0.006). Relative to the changes of TRE + LCD, TRE significantly increased role-emotional in the SF-36 (19.9 [95% CI 4.9 to 34.8]; P = 0.006). Changes in sleep quality, mood status, appetite, and metabolic hormones did not differ among three groups. Greater weight loss was associated with decreased leptin levels (r = 0.538), decreased amylin levels (r = 0.294), reduced total appetite scores (r = 0.220), and improved general health (r = -0.253) (all P <= 0.01). Conclusions: TRE, LCD, and TRE + LCD all could improve psychosocial health and reduce appetite. Notably, TRE yielded greater benefits in QoL compared with LCD or TRE + LCD in individuals with MetS. (c) 2024 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
C1 [Zheng, Yixuan; Yang, Jing; Wang, Yue; Qiang, Wei; Guo, Hui; Wang, Yanan; Shi, Bingyin; He, Mingqian] Xi An Jiao Tong Univ, Af?liated Hosp 1, Dept Endocrinol, 277 West Yanta Rd, Xian 710061, Shaanxi, Peoples R China.
   [Wang, Xin; Yang, Jing; Li, Qian; Zhu, Wenzhi; Wang, Yanan; He, Mingqian] Xi An Jiao Tong Univ, Affiliated Hosp 1, Med X Inst, Ctr Immunol & Metab Dis, 277 West Yanta Rd, Xian 710061, Shaanxi, Peoples R China.
   [Wang, Jingya] Xi An Jiao Tong Univ, Xian Childrens Hosp, Affiliated Childrens Hosp, Shaanxi Res Inst Pediat Dis,Dept Gastroenterol, 69 Xiju Yuan Lane, Xian 710003, Shaanxi, Peoples R China.
   [Wang, Jingya] Natl Reg Med Ctr Children Northwest, 69 Xiju Yuan Lane, Xian 710003, Shaanxi, Peoples R China.
   [Wang, Ting] Shaanxi Prov Peoples Hosp, Dept Cardiovasc Med, 256 Youyi West Rd, Xian 710068, Shaanxi, Peoples R China.
   [Sui, Jing] Xi An Jiao Tong Univ, Affiliated Hosp 1, Dept Endocrinol, 277 West Yanta Rd, Xian 710061, Shaanxi, Peoples R China.
   [Sui, Jing] Xi An Jiao Tong Univ, Affiliated Hosp 1, Int Med Ctr, 277 West Yanta Rd, Xian 710061, Shaanxi, Peoples R China.
C3 Xi'an Jiaotong University; Xi'an Jiaotong University; Xi'an Jiaotong
   University; Xi'an Medical University; Xi'an Jiaotong University; Xi'an
   Jiaotong University
RP He, MQ (corresponding author), Xi An Jiao Tong Univ, Af?liated Hosp 1, Dept Endocrinol, 277 West Yanta Rd, Xian 710061, Shaanxi, Peoples R China.
EM mingqian_he@xjtufh.edu.cn
RI Wang, Yanan/C-4143-2019; 郭, 卉/JGD-4929-2023
OI Wang, Yanan/0000-0002-0327-0458; He, Mingqian/0009-0003-1239-5740
FU Natural Science Foundation Program of Shaanxi [2024JC-YBQN-0828,
   2023-JC-QN-0927]; Key Research and Development Program of Shaanxi
   [2023-ZDLSF-40]; Fundamental Research Funds of Xi'an Jiaotong University
   [xtr052023011]; China "Thousand Talents Plan" (Young Talents) , Shaanxi
   Province "Thousand Talents Plan" (Young Talents); Foundation of Xi'an
   Jiaotong University (Plan A)
FX This study was supported by the Natural Science Foundation Program of
   Shaanxi (No. 2024JC-YBQN-0828 and 2023-JC-QN-0927) , the Key Research
   and Development Program of Shaanxi (No. 2023-ZDLSF-40) , and the
   Fundamental Research Funds of Xi'an Jiaotong University (No.
   xtr052023011) . Y.-N.W. is supported by the China "Thousand Talents
   Plan" (Young Talents) , Shaanxi Province "Thousand Talents Plan" (Young
   Talents) , and Foundation of Xi'an Jiaotong University (Plan A) .
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NR 57
TC 4
Z9 4
U1 9
U2 13
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0261-5614
EI 1532-1983
J9 CLIN NUTR
JI Clin. Nutr.
PD OCT
PY 2024
VL 43
IS 10
BP 2316
EP 2324
DI 10.1016/j.clnu.2024.08.029
EA SEP 2024
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA F2R3R
UT WOS:001308342200001
PM 39226719
OA hybrid
DA 2025-06-11
ER

PT J
AU Erdamar, H
   Sen, N
   Tavil, Y
   Yazici, HU
   Turfan, M
   Poyraz, F
   Topal, S
   Okuyan, H
   Cemri, M
   Cengel, A
AF Erdamar, Husamettin
   Sen, Nihat
   Tavil, Yusuf
   Yazici, Huseyin Ugur
   Turfan, Murat
   Poyraz, Fatih
   Topal, Salih
   Okuyan, Hizir
   Cemri, Mustafa
   Cengel, Atiye
TI The effect of nebivolol treatment on oxidative stress and antioxidant
   status in patients with cardiac syndrome-X
SO CORONARY ARTERY DISEASE
LA English
DT Article
DE cardiac syndrome-X; free radicals; nebivolol
ID HUMAN ATHEROSCLEROTIC INTIMA; ACUTE CORONARY SYNDROMES; ANGINA-PECTORIS;
   ENDOTHELIAL DYSFUNCTION; NITRIC-OXIDE; HYPERTENSIVE PATIENTS;
   LIPID-PEROXIDATION; CHEST-PAIN; MYELOPEROXIDASE; INACTIVATION
AB Background Free radical-mediated oxidative stress has been implicated in the etiopathogenesis of several disorders. The aim of this study was to elucidate the effect of treatment with nebivolol on the metabolic state of oxidative stress, and antioxidant status markers in patients with cardiac syndrome-X (CSX), additionally, to compare with the effect of metoprolol treatment.
   Methods Thirty patients, 17 female and 13 male, with CSX were enrolled in the study. Nebivolol (5 mg/day) or metoprolol (50 mg/day) was administrated for 12 weeks. Twelve hour fasting blood samples, taken at the initiation and on the third month of therapy, were analyzed for the levels of malondialdehyde WDA), nitrite+nitrate (NOx), and the activity of myeloperoxidase (MPO), superoxide dismutase (SOD). No patient presented additional risk factors for increased reactive oxygen species levels.
   Results Compared with sixteen control participants, patients with CSX had significantly higher activity of MPO and levels of MDA, but significantly lower SOD activity and levels of NOx before treatment. After treatment, MPO activity and MDA levels were significantly reduced; SOD activity and NOx levels were significantly increased with nebivolol but remained unchanged with metoprolol.
   Conclusion We have shown that patients with CSX who taken nebivolol have lower serum MPO activity, levels of MDA and higher serum SOD activity, NOx levels when compared with metoprolol treatment. Exercise stress test parameters were also ameliorated in patients who had taken nebivolol in contrast to metoprolol. Nebivolol treatment may be a novel treatment strategy in cases with CSX in the future. Coron Artery Dis 20:238-244 (C) 2009 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
C1 [Sen, Nihat] Gazi Univ, Fac Med, Dept Cardiol, Sch Med, Ankara, Turkey.
   [Erdamar, Husamettin] Tunceli Govt Hosp, Dept Med Biochem, Tunceli, Turkey.
C3 Gazi University; Tunceli State Hospital
RP Sen, N (corresponding author), Gazi Univ, Fac Med, Dept Cardiol, Sch Med, Ankara, Turkey.
EM nihatdrsen@yahoo.com
RI Turfan, Murat/B-8972-2014; Durakoglugil, Emre/Q-3547-2019; Poyraz,
   Fatih/JZD-3254-2024; okuyan, hizir/LZH-1858-2025
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NR 36
TC 36
Z9 37
U1 0
U2 12
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0954-6928
EI 1473-5830
J9 CORONARY ARTERY DIS
JI Coronary Artery Dis.
PD MAY
PY 2009
VL 20
IS 3
BP 238
EP 244
DI 10.1097/MCA.0b013e32830936bb
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 442XU
UT WOS:000265874800010
PM 19396947
DA 2025-06-11
ER

PT J
AU Gupta, A
   Uribarri, J
AF Gupta, Anshu
   Uribarri, Jaime
TI Dietary Advanced Glycation End Products and Their Potential Role in
   Cardiometabolic Disease in Children
SO HORMONE RESEARCH IN PAEDIATRICS
LA English
DT Review
DE Obesity; Children; Insulin resistance; Metabolic syndrome; Advanced
   glycation end products; Receptor of advanced glycation end products
ID OXIDATIVE STRESS; INSULIN SENSITIVITY; OBESE CHILDREN; DIABETIC
   ATHEROSCLEROSIS; GLYCOXIDATION PRODUCTS; GENE POLYMORPHISMS;
   RISK-FACTORS; LIFE-STYLE; RAGE AXIS; MICE
AB The rising incidence of obesity and metabolic diseases such as diabetes mellitus and cardiovascular disease in adolescents and young adults is of grave concern. Recent studies favor a role of lifestyle factors over genetics in the perpetuation of inflammation, insulin resistance and oxidative stress, which are pathophysiologic processes common to the above diseases; furthermore, the importance of dietary factors in addition to calories and physical activity in these processes is being increasingly recognized. Advanced glycation end products (AGEs) belong to a category of dietary oxidants which have been implicated in the pathogenesis of inflammation, oxidative stress, insulin resistance, beta-cell failure and endothelial dysfunction. This paper reviews the studies of AGEs with a focus on their role in cardiometabolic disease in children. A Medline search was performed using the key words 'childhood obesity', 'metabolic syndrome' and 'advanced glycation end products'. Articles published in English between 1975 and 2015 and their references were reviewed. While most studies were performed in adults, a few studies also demonstrated a role of AGEs in obesity and associated cardiometabolic comorbidities in the younger population. Available evidence suggests an involvement of AGEs in the pathogenesis of adiposity and beta-cell failure in children. Potential areas for further research to investigate underlying mechanisms are proposed. (C) 2016 S. Karger AG, Basel
C1 [Gupta, Anshu] Virginia Commonwealth Univ, Dept Pediat, Richmond, VA USA.
   [Uribarri, Jaime] Icahn Sch Med Mt Sinai, Dept Med, Div Nephrol, New York, NY 10029 USA.
C3 Virginia Commonwealth University; Icahn School of Medicine at Mount
   Sinai
RP Gupta, A (corresponding author), POB 980140, Richmond, VA 23298 USA.
EM Anshu.gupta@vcuhealth.org
RI Uribarri, Jaime/ADX-7655-2022
OI uribarri, jaime/0000-0001-9826-1134
FU National Institutes of Health [KL2TR000057]
FX A. G. was supported by KL2TR000057 as part of an institutional Clinical
   and Translational Science Award to Virginia Commonwealth University by
   the National Institutes of Health. The sponsor did not have any role in
   any part of the preparation of this article.
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NR 51
TC 28
Z9 30
U1 1
U2 11
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1663-2818
EI 1663-2826
J9 HORM RES PAEDIAT
JI Horm. Res. Paediatr.
PY 2016
VL 85
IS 5
BP 291
EP 300
DI 10.1159/000444053
PG 10
WC Endocrinology & Metabolism; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Pediatrics
GA DO7YO
UT WOS:000377999200001
PM 27008270
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Barbalho, SM
   Direito, R
   Laurindo, LF
   Marton, LT
   Guiguer, EL
   Goulart, RD
   Tofano, RJ
   Carvalho, ACA
   Flato, UAP
   Tofano, VAC
   Detregiachi, CRP
   Bueno, PCS
   Girio, RSJ
   Araújo, AC
AF Barbalho, Sandra Maria
   Direito, Rosa
   Laurindo, Lucas Fornari
   Marton, Ledyane Taynara
   Guiguer, Elen Landgraf
   Goulart, Ricardo de Alvares
   Tofano, Ricardo Jose
   Carvalho, Antonely C. A.
   Prync Flato, Uri Adrian
   Capelluppi Tofano, Viviane Alessandra
   Penteado Detregiachi, Claudia Rucco
   Santos Bueno, Patricia C.
   Girio, Raul S. J.
   Araujo, Adriano Cressoni
TI Ginkgo biloba in the Aging Process: A Narrative Review
SO ANTIOXIDANTS
LA English
DT Article
DE Gingko biloba; aging; neurodegenerative diseases; Alzheimer's disease;
   metabolic syndrome; cardiovascular disease; cancer
ID MILD COGNITIVE IMPAIRMENT; EXTRACT EGB 761(R); NF-KAPPA-B; WESTERN
   MEDICINE THERAPY; DOUBLE-BLIND; METABOLIC SYNDROME; INDUCED APOPTOSIS;
   OXIDATIVE STRESS; MOLECULAR-MECHANISMS; INSULIN-RESISTANCE
AB Neurodegenerative diseases, cardiovascular disease (CVD), hypertension, insulin resistance, cancer, and other degenerative processes commonly appear with aging. Ginkgo biloba (GB) is associated with several health benefits, including memory and cognitive improvement, in Alzheimer's disease (AD), Parkinson's disease (PD), and cancer. Its antiapoptotic, antioxidant, and anti-inflammatory actions have effects on cognition and other conditions associated with aging-related processes, such as insulin resistance, hypertension, and cardiovascular conditions. The aim of this study was to perform a narrative review of the effects of GB in some age-related conditions, such as neurodegenerative diseases, CVD, and cancer. PubMed, Cochrane, and Embase databases were searched, and the PRISMA guidelines were applied. Fourteen clinical trials were selected; the studies showed that GB can improve memory, cognition, memory scores, psychopathology, and the quality of life of patients. Moreover, it can improve cerebral blood flow supply, executive function, attention/concentration, non-verbal memory, and mood, and decrease stress, fasting serum glucose, glycated hemoglobin, insulin levels, body mass index, waist circumference, biomarkers of oxidative stress, the stability and progression of atherosclerotic plaques, and inflammation. Therefore, it is possible to conclude that the use of GB can provide benefits in the prevention and treatment of aging-related conditions.
C1 [Barbalho, Sandra Maria; Guiguer, Elen Landgraf; Goulart, Ricardo de Alvares; Tofano, Ricardo Jose; Carvalho, Antonely C. A.; Prync Flato, Uri Adrian; Penteado Detregiachi, Claudia Rucco; Santos Bueno, Patricia C.; Araujo, Adriano Cressoni] Univ Marilia UNIMAR, Postgrad Program Struct & Funct Interact Rehabil, BR-17525902 Marilia, SP, Brazil.
   [Barbalho, Sandra Maria; Laurindo, Lucas Fornari; Marton, Ledyane Taynara; Guiguer, Elen Landgraf; Tofano, Ricardo Jose; Prync Flato, Uri Adrian; Capelluppi Tofano, Viviane Alessandra; Araujo, Adriano Cressoni] Univ Marilia UNIMAR, Sch Med, Dept Biochem & Pharmacol, Ave Higino Muzzi Filho 1001, BR-17525902 Marilia, SP, Brazil.
   [Barbalho, Sandra Maria; Guiguer, Elen Landgraf] Sch Food & Technol Marilia FATEC, Ave Castro Alves, BR-17500000 Marilia, SP, Brazil.
   [Direito, Rosa] Univ Lisbon, Fac Farm, Res Inst Med iMed ULisboa, Lab Syst Integrat Pharmacol Clin & Regulatory Sci, Av Prof Gama Pinto, P-1649003 Lisbon, Portugal.
   [Santos Bueno, Patricia C.; Girio, Raul S. J.] Univ Marilia UNIMAR, Sch Vet Med, Dept Anim Sci, Ave Higino Muzzi Filho 1001, BR-17525902 Marilia, SP, Brazil.
C3 Universidade de Marilia; Universidade de Marilia; Universidade de
   Lisboa; Universidade de Marilia
RP Barbalho, SM (corresponding author), Univ Marilia UNIMAR, Postgrad Program Struct & Funct Interact Rehabil, BR-17525902 Marilia, SP, Brazil.; Barbalho, SM (corresponding author), Univ Marilia UNIMAR, Sch Med, Dept Biochem & Pharmacol, Ave Higino Muzzi Filho 1001, BR-17525902 Marilia, SP, Brazil.; Barbalho, SM (corresponding author), Sch Food & Technol Marilia FATEC, Ave Castro Alves, BR-17500000 Marilia, SP, Brazil.
EM smbarbalho@gmail.com; rdireito@ff.ulisboa.pt; 1851730@unimar.br;
   1813975@unimar.br; eleng@unimar.br; rgoulart@unimar.br;
   ricardo.tofano@unimar.br; antonely.prefeito@ibaiti.pr.gov.br;
   uriflato@unimar.br; viviane.tofano@unimar.br;
   claudia.detregiachi@unimar.br; patriciabueno@unimar.br;
   rgirio@unimar.br; araujo.01@unimar.br
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   Rosa/S-4473-2019; Girio, Raul/M-9085-2018
OI FORNARI LAURINDO, LUCAS/0000-0003-3159-0982; Guiguer,
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   Flato, Uri Adrian/0000-0002-8381-8830; Girio, Raul/0000-0002-8845-8985
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NR 145
TC 51
Z9 51
U1 2
U2 28
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD MAR
PY 2022
VL 11
IS 3
AR 525
DI 10.3390/antiox11030525
PG 27
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA 0E8CK
UT WOS:000776902500001
PM 35326176
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Piras, F
   Banaj, N
   Porcari, DE
   Piras, F
   Spalletta, G
AF Piras, Federica
   Banaj, Nerisa
   Porcari, Desiree E.
   Piras, Fabrizio
   Spalletta, Gianfranco
TI Later life depression as risk factor for developing dementia:
   epidemiological evidence, predictive models, preventive strategies and
   future trends
SO MINERVA MEDICA
LA English
DT Review
DE Depressive disorders; Dementia; Risk factors; Prevention and control;
   Early medical intervention
ID MILD COGNITIVE IMPAIRMENT; ALZHEIMERS-DISEASE; NEUROPSYCHIATRIC
   SYMPTOMS; METABOLIC SYNDROME; ASSOCIATION; RESERVE; TRAJECTORIES;
   METAANALYSIS; HIPPOCAMPUS; VOLUME
AB Current investigations in pre-symptomatic dementia have suggested that depressive mood, a treatable condition, may play an important role in the development of the disorder. However, whether depression in adulthood constitute a risk factor, or a prodrome of dementia remains unclear. A major implication in such dispute is the analytic framework used to identify putative risk factors. Indeed, if evaluated in the years immediately prior to dementia diagnosis the association between depression and dementia may reflect depressive symptoms as a prodrome of yet-undiagnosed dementia. Unfortunately, long term prospective cohort investigations, reaching back into the preclinical phase of dementia are sparse. Here, we have surveyed high-quality evidence (systematic reviews and meta-analyses) on the association between depressive symptoms and increased odds of dementia. Meta-analytic findings are also presented and discussed regarding depression as a prodromal stage of dementia, or a consequence of underlying neurodegenerative processes. Additionally, the potential confounding effect of several variables on the risk association between depression and dementia, an aspect hardly investigated, is discussed. While early onset late-life depression - defined as starting before 60 years of age - increases the odds of developing dementia in predisposed subjects, late-onset depression appears to be a prodrome and a clear accelerating factor for cognitive deterioration. Since it is increasingly important to consider the potential of pre-emptive approaches to decrease the impact of dementia, evidence on potentially effective preventive strategies targeting depression as a risk factor, and next steps in further research are presented as concluding remarks.
C1 [Piras, Federica; Banaj, Nerisa; Porcari, Desiree E.; Piras, Fabrizio; Spalletta, Gianfranco] IRCCS Santa Lucia Fdn, Dept Clin & Behav Neurol, Lab Neuropsychiat, Via Ardeatina 306, I-00179 Rome, Italy.
   [Spalletta, Gianfranco] Baylor Coll Med, Menninger Dept Psychiat & Behav Sci, Houston, TX 77030 USA.
C3 IRCCS Santa Lucia; Baylor College of Medicine
RP Spalletta, G (corresponding author), IRCCS Santa Lucia Fdn, Dept Clin & Behav Neurol, Lab Neuropsychiat, Via Ardeatina 306, I-00179 Rome, Italy.
EM g.spalletta@hsantalucia.it
RI Piras, Federica/AAC-4768-2022; Banaj, Nerisa/AAC-3880-2022; piras,
   fabrizio/M-7902-2016
OI piras, fabrizio/0000-0003-3566-5494; Porcari, Desiree
   Estela/0000-0003-4338-1547
FU Italian Ministry of Health [RC18-19-20-21/A]
FX This research was funded by RC18-19-20-21/A grants from the Italian
   Ministry of Health. The authors report no involvement in the research by
   the funder that could have influenced the outcome of this work.
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NR 50
TC 27
Z9 28
U1 1
U2 5
PU EDIZIONI MINERVA MEDICA
PI TURIN
PA CORSO BRAMANTE 83-85 INT JOURNALS DEPT., 10126 TURIN, ITALY
SN 0026-4806
EI 1827-1669
J9 MINERVA MED
JI Minerva Med.
PD AUG
PY 2021
VL 112
IS 4
BP 456
EP 466
DI 10.23736/S0026-4806.21.07571-6
PG 11
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA TK7MU
UT WOS:000674340400005
PM 34056888
DA 2025-06-11
ER

PT J
AU Marín-Echeverri, C
   Blesso, CN
   Fernández, ML
   Galvis-Pérez, Y
   Ciro-Gómez, G
   Núñez-Rangel, V
   Aristizábal, JC
   Barona-Acevedo, J
AF Marin-Echeverri, Catalina
   Blesso, Christopher N.
   Fernandez, Maria Luz
   Galvis-Perez, Yeisson
   Ciro-Gomez, Gelmy
   Nunez-Rangel, Vitelbina
   Aristizabal, Juan C.
   Barona-Acevedo, Jacqueline
TI Effect of Agraz (Vaccinium meridionale Swartz) on High-Density
   Lipoprotein Function and Inflammation in Women with Metabolic Syndrome
SO ANTIOXIDANTS
LA English
DT Article
DE Andean berry; cardiovascular risk factors; HDL dysfunction;
   inflammation; oxidative stress
ID APOLIPOPROTEIN-A-I; NF-KAPPA-B; CHOLESTEROL EFFLUX CAPACITY; PARAOXONASE
   1 ACTIVITY; ANTIOXIDANT ACTIVITY; OXIDATIVE STRESS; HDL; ANTHOCYANINS;
   MYELOPEROXIDASE; EXTRACT
AB Metabolic syndrome (MetS) is associated with low-grade inflammation and high-density lipoprotein (HDL) dysfunction. Polyphenol-rich foods may improve these alterations. Agraz is a fruit rich in polyphenols (mainly anthocyanins); however, there is limited information about its effects on human health. We evaluated the effects of agraz consumption as compared to placebo on HDL function and inflammation in women with MetS. Forty volunteers (25-60 years) were included in this double-blind crossover study. Women consumed agraz or placebo over 4 weeks; separated by a 4-week washout period. HDL function (apoliprotein-A1; paraoxonase 1 (PON1) activity; cholesterol efflux capacity), oxidative stress (myeloperoxidase (MPO), advanced oxidation protein products) and inflammatory markers (serum cytokines/chemokines and peripheral blood mononuclear cell nuclear factor-kB) were measured after each period. Compared to placebo, agraz consumption did not significantly change any of the biomarkers measured. Interestingly, only after agraz period there were significant positive correlations between PON1 activities and cholesterol efflux. Additionally, there were significant inverse correlations between changes in inflammatory markers and HDL function markers and positive correlations with oxidative markers. Although polyphenol-rich foods have been shown to be beneficial for certain conditions; polyphenol-rich agraz fruit consumption did not impact inflammation and HDL function in the current study of women with MetS.
C1 [Marin-Echeverri, Catalina; Galvis-Perez, Yeisson; Ciro-Gomez, Gelmy; Nunez-Rangel, Vitelbina; Barona-Acevedo, Jacqueline] Univ Antioquia UdeA, Sch Microbiol, Ophidism Program, Food & Therapeut Alternat Area, Calle 70 52-21, Medellin 050010, Colombia.
   [Blesso, Christopher N.; Fernandez, Maria Luz] Univ Connecticut, Dept Nutr Sci, Storrs, CT 06269 USA.
   [Aristizabal, Juan C.] Univ Antioquia UdeA, Sch Nutr & Dietet, Res Grp Physiol & Biochem PHYSIS, Calle 70 52-21, Medellin 050010, Colombia.
C3 Universidad de Antioquia; University of Connecticut; Universidad de
   Antioquia
RP Barona-Acevedo, J (corresponding author), Univ Antioquia UdeA, Sch Microbiol, Ophidism Program, Food & Therapeut Alternat Area, Calle 70 52-21, Medellin 050010, Colombia.
EM catalina.marin@udea.edu.co; christopher.blesso@uconn.edu;
   maria-luz.fernandez@uconn.edu; yeisson.galvis@udea.edu.co;
   gelmy.ciro@udea.edu.co; vitelbina.nunez@udea.edu.co;
   juan.aristizabal@udea.edu.co; maria.barona@udea.edu.co
RI Acevedo, Maria/A-8759-2019; Rivera, Juan/B-6591-2014; Blesso,
   Christopher/N-9495-2014
OI Barona Acevedo, Maria Jacqueline/0000-0002-0592-9324; Blesso,
   Christopher/0000-0002-4434-4839; Aristizabal, Juan/0000-0001-5781-5903;
   Marin Echeverri, Catalina/0000-0002-4267-5677; Ciro Gomez, Gelmy
   Luz/0000-0003-2559-4776; Fernandez, Maria-Luz/0000-0002-1835-0792;
   Galvis Perez, Yeisson/0000-0002-3600-2580
FU Departamento Administrativo de Ciencia, Tecnologia e
   Innovacion-Colciencias [111565740563, 657-2014, FP44842-124-2017];
   University of Antioquia UdeA, Medellin-Colombia
FX This study was supported by Departamento Administrativo de Ciencia,
   Tecnologia e Innovacion-Colciencias through two different grants:
   111565740563, Contract No. 657-2014 and FP44842-124-2017; and the
   University of Antioquia UdeA, Medellin-Colombia.
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NR 58
TC 17
Z9 17
U1 0
U2 11
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD DEC
PY 2018
VL 7
IS 12
AR 185
DI 10.3390/antiox7120185
PG 14
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA HG1JF
UT WOS:000454709200016
PM 30544803
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Leu, HB
   Lin, CP
   Lin, WT
   Wu, TC
   Lin, SJ
   Chen, JW
AF Leu, HB
   Lin, CP
   Lin, WT
   Wu, TC
   Lin, SJ
   Chen, JW
TI Circulating mononuclear superoxide production and inflammatory markers
   for long-term prognosis in patients with cardiac syndrome X
SO FREE RADICAL BIOLOGY AND MEDICINE
LA English
DT Article
DE cardiac syndrome X; mononuclear cell; prognosis; soluble vascular cell
   adhesion molecule-1; superoxide; free radicals
ID NORMAL CORONARY ANGIOGRAMS; C-REACTIVE PROTEIN; LEFT-VENTRICULAR
   FUNCTION; CHEST-PAIN; OXIDATIVE-STRESS; CLINICAL CHARACTERISTICS;
   MYOCARDIAL-ISCHEMIA; ANGINA-PECTORIS; ARTERY-DISEASE; OXIDANT STRESS
AB Increased oxidative stress and vascular inflammation have been shown in patients with cardiac syndrome X (CSX: angina, exercise-induced ischemia, and normal coronary angiogram). This study was conducted to assess the impact of basal superoxide generation by circulating mononuclear cells (MNCs), a contributor to intravascular oxidative stress, and serum inflammatory biomarkers, including high-sensitivity C-reactive protein, homocysteine, soluble intercellular adhesion molecule-1, soluble vascular adhesion molecule-1, and von Willebrand factor, on the long-term prognosis of CSX. During a mean follow-up of 31.5 +/- 14.2 months (maximum 5 years), a total of 12 events were recorded in 92 consecutive CSX patients. There were no deaths or myocardial infarctions, but 8 hospitalizations for acute coronary syndrome, 3 for stroke, and 1 for congestive heart failure due to left ventricular systolic dysfunction. Under univariate analysis, only basal superoxide generation by MNCs was associated with the risk for cardiovascular event. Based on multivariate analysis, basal superoxide generation by MNCs could still independently predict future events (relative risk for the highest compared to the lowest tertile, 3.87, 95% confidence interval, 1.42-10.54, p = 0.008). These findings demonstrate that long-term prognosis is fair in patients with CSX. Basal superoxide production of MNCs independently predicts future cardiovascular events, suggesting its potential role in measuring disease progression and risk stratification in these patients. (C) 2005 Elsevier Inc. All rights reserved.
C1 Natl Yang Ming Univ, Sch Med, Cardiovasc Res Ctr, Taipei 112, Taiwan.
   Natl Yang Ming Univ, Sch Med, Inst Clin Med, Taipei 112, Taiwan.
   Taipei Vet Gen Hosp, Dept Med, Div Cardiol, Taipei, Taiwan.
   Taipei Vet Gen Hosp, Dept Pathol, Taipei, Taiwan.
C3 National Yang Ming Chiao Tung University; National Yang Ming Chiao Tung
   University; Taipei Veterans General Hospital; Taipei Veterans General
   Hospital
RP Natl Yang Ming Univ, Sch Med, Cardiovasc Res Ctr, Taipei 112, Taiwan.
EM jwchen@vghtpe.gov.tw
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NR 41
TC 27
Z9 28
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0891-5849
EI 1873-4596
J9 FREE RADICAL BIO MED
JI Free Radic. Biol. Med.
PD MAR 15
PY 2006
VL 40
IS 6
BP 983
EP 991
DI 10.1016/j.freeradbiomed.2005.10.047
PG 9
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 027GX
UT WOS:000236404100009
PM 16540394
DA 2025-06-11
ER

PT J
AU Bjelanovic, V
   Babic, D
   Oreskovic, S
   Tomic, V
   Martinac, M
   Juras, J
AF Bjelanovic, Vedran
   Babic, Dragan
   Oreskovic, Slavko
   Tomic, Vajdana
   Martinac, Marko
   Juras, Josip
TI Pathological Pregnancy and Psychological Symptoms in Women
SO COLLEGIUM ANTROPOLOGICUM
LA English
DT Article
DE pathology and normal pregnancy; psychological symptoms; metabolic
   syndrome
ID HYPERTENSION; DEPRESSION; ANXIETY
AB Pregnancy is followed by many physiologic, organic and psychological changes and disorders, which can become more serious in pregnancy followed by complications, especially in women with pathological conditions during pregnancy. The purpose of this study was to find out and analyze the prevalence and intensity of psychological disorders in women with pathological conditions during pregnancy and compare it with conditions in pregnant women who had normal development of pregnancy. The research is approved by the Ethical committee of the Mostar University Hospital Center, and it was made in accordance with Helsinki declaration and good clinical practices. The research conducted section for pathology of pregnancy of Department for gynecology and obstetrics of the Mostar University Hospital Center It included 82 pregnant women with disorders in pregnancy developement and control group consisted of pregnant women who had normal development of pregnancy. The research work was conducted from September 2007 to August 2008 in Mostar University Hospital Center. Pregnant women had Standard and laboratory tests, Ultrasound. CTG examinations were done for all pregnant women and additional tests for those women with complications during pregnancy. Pregnant women completed sociobiographical, obstetrical-clinical and psychological SCL 90-R questionnaire. Pregnant women with pathological pregnancy exibited significantly more psychological symptoms in comparison to pregnant women with normal pregnancy (p<0.001 to p=0.004). Frequency and intensity of psychical symptoms and disorders statisticly are more characteristic in pathological pregnancy (61%/40.6%). The statistical data indicate a significantly higher score of psychological disorders in those pregnant women with primary school education (p=0.050), those who take more than 60% carbohydrates (p=0.001), those with pathological CTG records (p<0.001), those with pathological ultrasound results (p<0.001 to 0.216) and those pregnant women with medium obesity and obesity (p=0.046). Body mass index (BMI) during normal pregnancy development is lower (p=0.002) but the levels of glucose, triglycerides, cholesterol, HDL and LDL in blood are higher. Blood pressure in pregnant women with pathological pregnancy was statistically significantly higher (p<0.001). Diagnostic criteria for the metabolic syndrome were found in 19 pregnant women with the pathological pregnancy. Statistically, in those women, a significantly higher appearance of psychological symptoms and disorders was observed in comparison to the pregnant women without metabolic syndrome (p<0.001). The research has shown that 87.8% from all pregnant women included in this study have been hospitalized due to premature birth, hypertensive disorders, and diabetes in pregnancy, and also due to bleeding in the second and third trimester of pregnancy.
C1 [Bjelanovic, Vedran; Oreskovic, Slavko; Tomic, Vajdana] Mostar Univ, Ctr Hosp, Dept Gynecol & Obstet, Mostar 88000, Bosnia & Herceg.
   [Babic, Dragan; Martinac, Marko] Mostar Univ, Ctr Hosp, Dept Psychiat, Mostar 88000, Bosnia & Herceg.
   [Oreskovic, Slavko; Juras, Josip] Univ Zagreb, Ctr Hosp, Dept Gynecol & Obstet, Zagreb 41000, Croatia.
C3 University of Mostar; University of Mostar; University of Zagreb
RP Bjelanovic, V (corresponding author), Mostar Univ, Ctr Hosp, Dept Gynecol & Obstet, Mostar 88000, Bosnia & Herceg.
EM vedranbjelanovic@yahoo.com
OI Juras, Josip/0000-0002-1801-5732; Martinac, Marko/0000-0001-9144-6427
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NR 24
TC 5
Z9 5
U1 0
U2 13
PU COLLEGIUM ANTROPOLOGICUM
PI ZAGREB
PA INST ANTHROPOLOGICAL RESEARCH, GAJEVA 32, PO BOX 290, HR-10000 ZAGREB,
   CROATIA
SN 0350-6134
J9 COLLEGIUM ANTROPOL
JI Coll. Anthropol.
PD SEP
PY 2012
VL 36
IS 3
BP 847
EP 852
PG 6
WC Anthropology
WE Social Science Citation Index (SSCI)
SC Anthropology
GA 031TB
UT WOS:000310664100020
PM 23213943
DA 2025-06-11
ER

PT J
AU Fraga, MC
   Moura, EG
   Silva, JO
   Bonomo, IT
   Filgueiras, CC
   Abreu-Villaça, Y
   Passos, MCF
   Lisboa, PC
   Manhaes, AC
AF Fraga, Mabel C.
   Moura, Egberto G.
   Silva, Juliana Oliveira
   Bonomo, Isabela Teixeira
   Filgueiras, Claudio C.
   Abreu-Villaca, Yael
   Passos, Magna C. F.
   Lisboa, Patricia C.
   Manhaes, Alex C.
TI Maternal prolactin inhibition at the end of lactation affects
   learning/memory and anxiety-like behaviors but not novelty-seeking in
   adult rat progeny
SO PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
LA English
DT Article
DE Hypoprolactinemia; Early weaning; Developmental plasticity; Behavior;
   Rats
ID ADOLESCENT C57BL/6 MICE; THYROID-HORMONE ACTION; ELEVATED PLUS-MAZE;
   PRENATAL STRESS; METABOLIC SYNDROME; FEMALE RATS; CENTRAL
   HYPOTHYROIDISM; DEVELOPMENTAL ORIGINS; HIPPOCAMPAL-FORMATION;
   EXPLORATORY-BEHAVIOR
AB Maternal hypoprolactinemia at the end of lactation in rats reduces milk production and is associated with offspring's malnutrition. Since malnutrition during development is also known to have long lasting effects on cognition and emotion, in the present study we tested the hypothesis that maternal hypoprolactinemia, induced by bromocriptine treatment, at the end of the lactating period affects memory/learning, novelty-seeking and anxiety-like behaviors in adult male Wistar rats using, respectively, the radial arm water maze (RAWM), the hole board (HB) arena and the elevated plus-maze (EPNl). We also analyzed serum corticosterone and thyroid hormone levels at postnatal day (PN) 21. Lactating dams were treated with bromocriptine (BRO, 1 mg twice a day, inhibiting prolactin) or saline from PN19 to 21 (the last 3 days of lactation). BRO offspring had hypercorticosteronemia and hypothyroidism at PN21. In the RAWM, reductions in latency observed in CON rats were initially more accentuated than in BRO ones. By the end of the testing period, latencies became similar between groups. No difference was observed between groups regarding the number of nose-pokes in the HB. In the EPM, BRO rats stayed less time in and had fewer entries into the open-arms than CON ones. This pattern of results indicates that maternal bromocriptine treatment at the end of the lactating period results in poorer memory/learning performance and in higher levels of anxiety-like behavior in the adult offspring, demonstrating that even a relatively short period of malnutrition during development can have long lasting detrimental effects regarding cognition and emotion. (C) 2011 Elsevier Inc. All rights reserved.
C1 [Fraga, Mabel C.; Silva, Juliana Oliveira; Filgueiras, Claudio C.; Abreu-Villaca, Yael; Manhaes, Alex C.] Univ Estado Rio de Janeiro, Lab Neurofisiol, Dept Ciencias Fisiol, Inst Biol Roberto Alcantara Gomes,Ctr Biomed, BR-20550170 Rio De Janeiro, Brazil.
   [Fraga, Mabel C.; Moura, Egberto G.; Silva, Juliana Oliveira; Bonomo, Isabela Teixeira; Passos, Magna C. F.; Lisboa, Patricia C.] Univ Estado Rio de Janeiro, Lab Fisiol Endocrina, Dept Ciencias Fisiol, Inst Biol Roberto Alcantara Gomes,Ctr Biomed, BR-20550170 Rio De Janeiro, Brazil.
C3 Universidade do Estado do Rio de Janeiro; Universidade do Estado do Rio
   de Janeiro
RP Manhaes, AC (corresponding author), Univ Estado Rio de Janeiro, Lab Neurofisiol, Dept Ciencias Fisiol, Inst Biol Roberto Alcantara Gomes,Ctr Biomed, Av Prof Manuel de Abreu 444,5 Andar, BR-20550170 Rio De Janeiro, Brazil.
EM amanhaes@uerj.br
RI Manhães, Alex/F-5499-2011; Abreu-Villaca, Yael/D-5997-2015; Filgueiras,
   Claudio/MBG-9894-2025; Moura, Egberto/H-1270-2012; Lisboa,
   Patricia/H-8336-2015
OI Filgueiras, Claudio/0000-0003-4522-4799; Moura,
   Egberto/0000-0002-1159-7549; Lisboa, Patricia/0000-0002-2477-4364;
   Abreu-Villaca, Yael/0000-0002-9801-6179; Manhaes, Alex
   C./0000-0003-4629-8343
FU Fundacao Carlos Chagas Filho de Amparo Pesquisa do Estado do Rio de
   Janeiro (FAPERJ); Conselho Nacional de Desenvolvimento Cientifico e
   Tecnologico (CNPq); Coordenacao de Aperfeicoamento de Pessoal de Nivel
   Superior (CAPES); Sub-Reitoria de Pos-graduacao e Pesquisa da
   Universidade do Estado do Rio de Janeiro (SR2-UERJ)
FX Funding for this study was provided by Fundacao Carlos Chagas Filho de
   Amparo Pesquisa do Estado do Rio de Janeiro (FAPERJ), Conselho Nacional
   de Desenvolvimento Cientifico e Tecnologico (CNPq), Coordenacao de
   Aperfeicoamento de Pessoal de Nivel Superior (CAPES) and by Sub-Reitoria
   de Pos-graduacao e Pesquisa da Universidade do Estado do Rio de Janeiro
   (SR2-UERJ). MCF and ITB are recipients of FAPERJ postdoctoral
   fellowships, while JOS is recipient of CNPq fellowship for undergraduate
   students. The authors are thankful to Ulisses Risso Siqueira for the
   animal care.
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NR 102
TC 24
Z9 24
U1 1
U2 10
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0091-3057
J9 PHARMACOL BIOCHEM BE
JI Pharmacol. Biochem. Behav.
PD NOV
PY 2011
VL 100
IS 1
BP 165
EP 173
DI 10.1016/j.pbb.2011.07.007
PG 9
WC Behavioral Sciences; Neurosciences; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Behavioral Sciences; Neurosciences & Neurology; Pharmacology & Pharmacy
GA 838OP
UT WOS:000296302400023
PM 21777608
OA hybrid
DA 2025-06-11
ER

PT J
AU Galarregui, C
   Zulet, MA
   Cantero, I
   Marín-Alejandre, BA
   Monreal, JI
   Elorz, M
   Benito-Boillos, A
   Herrero, JI
   Tur, JA
   Abete, I
   Martínez, JA
AF Galarregui, Cristina
   Angeles Zulet, Maria
   Cantero, Irene
   Araceli Marin-Alejandre, Bertha
   Ignacio Monreal, Jose
   Elorz, Mariana
   Benito-Boillos, Alberto
   Ignacio Herrero, Jose
   Antoni Tur, Josep
   Abete, Itziar
   Alfredo Martinez, Jose
TI Interplay of Glycemic Index, Glycemic Load, and Dietary Antioxidant
   Capacity with Insulin Resistance in Subjects with a Cardiometabolic Risk
   Profile
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE antioxidants; glucose; diet; diabetes; precision nutrition
ID FOOD-FREQUENCY QUESTIONNAIRE; OXIDATIVE STRESS; ASSOCIATION;
   COMPLICATIONS; INFLAMMATION; SENSITIVITY; CONSUMPTION; DISEASE; PROTEIN;
   OBESITY
AB Background: Dietary total antioxidant capacity (TAC), glycemic index (GI), and glycemic load (GL) are accepted indicators of diet quality, which have an effect on diet-disease relationships. The aim of this study was to evaluate potential associations of dietary TAC, GI, and GL with variables related to nutritive status and insulin resistance (IR) risk in cardiometabolic subjects. Methods: A total of 112 overweight or obese adults (age: 50.8 +/- 9 years old) were included in the trial. Dietary intake was assessed by a validated 137-item food frequency questionnaire (FFQ), which was also used to calculate the dietary TAC, GI, and GL. Anthropometrics, blood pressure, body composition by dual-energy X-ray absorptiometry (DXA), glycemic and lipid profiles, C-reactive protein (CRP), as well as fatty liver quantification by magnetic resonance imaging (MRI) were assessed. Results: Subjects with higher values of TAC had significantly lower circulating insulin concentration and homeostatic model assessment of insulin resistance (HOMA-IR). Participants with higher values of HOMA-IR showed significantly higher GI and GL. Correlation analyses showed relevant inverse associations of GI and GL with TAC. A regression model evidenced a relationship of HOMA-IR with TAC, GI, and GL. Conclusion: This data reinforces the concept that dietary TAC, GI, and GL are potential markers of diet quality, which have an impact on the susceptible population with a cardiometabolic risk profile.
C1 [Galarregui, Cristina; Angeles Zulet, Maria; Cantero, Irene; Araceli Marin-Alejandre, Bertha; Abete, Itziar; Alfredo Martinez, Jose] Univ Navarra, Dept Nutr Food Sci & Physiol, Pamplona 31008, Spain.
   [Galarregui, Cristina; Angeles Zulet, Maria; Cantero, Irene; Araceli Marin-Alejandre, Bertha; Abete, Itziar; Alfredo Martinez, Jose] Univ Navarra, Ctr Nutr Res, Pamplona 31008, Spain.
   [Angeles Zulet, Maria; Antoni Tur, Josep; Abete, Itziar; Alfredo Martinez, Jose] Inst Salud Carlos III, Biomed Res Ctr Network Physiopathol Obes & Nutr C, Madrid 28029, Spain.
   [Angeles Zulet, Maria; Ignacio Monreal, Jose; Elorz, Mariana; Benito-Boillos, Alberto; Ignacio Herrero, Jose; Alfredo Martinez, Jose] Navarra Inst Hlth Res IdiSNA, Pamplona 31008, Spain.
   [Ignacio Monreal, Jose] Univ Navarra, Clin Chem Dept, Univ Clin Navarra, Pamplona 31008, Spain.
   [Elorz, Mariana; Benito-Boillos, Alberto] Univ Navarra, Univ Clin Navarra, Radiodiagnost Dept, Pamplona 31008, Spain.
   [Ignacio Herrero, Jose] Univ Navarra, Liver Unit, Univ Clin Navarra, Pamplona 31008, Spain.
   [Antoni Tur, Josep] Univ Illes Balears, Res Grp Community Nutr & Oxidat Stress, E-07122 Palma De Mallorca, Spain.
   [Alfredo Martinez, Jose] Madrid Inst Adv Studies IMDEA Food, Precis Nutr & Cardiometab Hlth Dept, Madrid 28049, Spain.
C3 University of Navarra; University of Navarra; Instituto de Salud Carlos
   III; University of Navarra; University of Navarra; University of
   Navarra; University of Navarra; Universitat de les Illes Balears; IMDEA
   Food Institute
RP Abete, I (corresponding author), Univ Navarra, Dept Nutr Food Sci & Physiol, Pamplona 31008, Spain.; Abete, I (corresponding author), Univ Navarra, Ctr Nutr Res, Pamplona 31008, Spain.; Abete, I (corresponding author), Inst Salud Carlos III, Biomed Res Ctr Network Physiopathol Obes & Nutr C, Madrid 28029, Spain.
EM cgalarregui@alumni.unav.es; mazulet@unav.es; icantero.1@alumni.unav.es;
   bmarin.1@alumni.unav.es; jimonreal@unav.es; marelorz@unav.es;
   albenitob@unav.es; iherrero@unav.es; pep.tur@uib.es; iabetego@unav.es;
   jalfmtz@unav.es
RI Zulet, M./H-1317-2017; Carlón, Mariana/ABD-5128-2021; Tur,
   Josep/AAE-5748-2020; Tur, Josep/F-5576-2014; Stefanadis,
   Christodoulos/ABH-2232-2020; Abete, Itziar/H-4827-2017; Benito,
   Alberto/AAD-4201-2020; Martinez Hernandez, J Alfredo/K-8709-2014
OI Tur, Josep/0000-0002-6940-0761; Marin Alejandre, Bertha
   Araceli/0000-0003-0741-8197; Stefanadis,
   Christodoulos/0000-0001-5974-6454; Abete, Itziar/0000-0002-6475-5387;
   Benito, Alberto/0000-0002-1527-0092; Elorz Carlon,
   Mariana/0000-0002-1580-3629; Martinez Hernandez, J
   Alfredo/0000-0001-5218-6941
FU Health Department of the Government of Navarra [61/2015]; CIBERobn
   (Physiopathology of Obesity and Nutrition); Fundacio La Marato de TV3
   [201630.10]; Congelados de Navarra; Ministerio de Educacion, Cultura y
   Deporte [FPU17/06330]; Government of Navarra
FX This research was funded by the Health Department of the Government of
   Navarra (61/2015), CIBERobn (Physiopathology of Obesity and Nutrition),
   and Fundacio La Marato de TV3 (201630.10). C.G. was partially supported
   by fellowships from Congelados de Navarra, Government of Navarra, and
   Ministerio de Educacion, Cultura y Deporte (FPU17/06330).
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NR 45
TC 29
Z9 29
U1 0
U2 3
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD NOV
PY 2018
VL 19
IS 11
AR 3662
DI 10.3390/ijms19113662
PG 12
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA HC0ZM
UT WOS:000451528500378
PM 30463312
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Yamagata, AS
   Mansur, RB
   Rizzo, LB
   Rosenstock, T
   McIntyre, RS
   Brietzke, E
AF Yamagata, Ana Sayuri
   Mansur, Rodrigo Barbachan
   Rizzo, Lucas Bortolotto
   Rosenstock, Tatiana
   McIntyre, Roger S.
   Brietzke, Elisa
TI Selfish brain and selfish immune system interplay: A theoretical
   framework for metabolic comorbidities of mood disorders
SO NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
LA English
DT Review
DE Bipolar disorder; Major depressive disorder; Brain energy metabolism;
   Immune system energy metabolism; Metabolic syndrome; Inflammation
ID MAJOR DEPRESSIVE DISORDER; ELEVATED SERUM-LEVELS; C-REACTIVE PROTEIN;
   BIPOLAR DISORDER; INSULIN-RESISTANCE; GLUCOSE-METABOLISM; 3T3-L1
   ADIPOCYTES; PREFRONTAL CORTEX; HORMONE-SECRETION; ALLOSTATIC LOAD
AB According to the "selfish brain" theory, the brain regulates its own energy supply influencing the peripheral metabolism and food intake according to its needs. The immune system has been likewise "selfish" due to independent energy consumption; and it may compete with the brain (another high energy consumer) for glucose. In mood disorders, stress in mood episodes or physiological stress activate homeostasis mechanisms from the brain and the immune system to solve the imbalance. The interaction between the selfish brain and the selfish immune system may explain various conditions of medical impairment in mood disorders, such as Metabolic Syndrome (MetS), obesity, type 2 diabetes mellitus (T2DM) and immune dysregulation. The objective of this study is to comprehensively review the literature regarding the competition between the brain and the immune system for energy substrate. Targeting the energetic regulation of the brain and the immune system and their cross-talk open alternative treatments and a different approach in the study of general medical comorbidities in mood disorders, although more investigation is needed. (C) 2016 Elsevier Ltd. All rights reserved.
C1 [Yamagata, Ana Sayuri] Univ Sao Paulo, Inst Biosci, R Matao 14,321 Butanta, BR-05508090 Sao Paulo, SP, Brazil.
   [Yamagata, Ana Sayuri; Mansur, Rodrigo Barbachan; Rizzo, Lucas Bortolotto; Brietzke, Elisa] Fed Univ Sao Paulo Unifesp, Res Grp Behav & Mol Neurosci Bipolar Disorder, Dept Psychiat, R Pedro de Toledo,669 3rd-Floor, BR-04039032 Sao Paulo, SP, Brazil.
   [Mansur, Rodrigo Barbachan; McIntyre, Roger S.] Univ Toronto, Mood Disorders Psychopharmachol Unit, 399 Bathurst St,MP 9-325, Toronto, ON M5T 2S8, Canada.
   [Rosenstock, Tatiana] Santa Casa Sao Paulo Med Sch, Dept Physiol Sci, R Doutor Cesario Motto Jr,61 Vila Buarque, BR-01221020 Sao Paulo, SP, Brazil.
C3 Universidade de Sao Paulo; Universidade Federal de Sao Paulo (UNIFESP);
   University of Toronto
RP Yamagata, AS (corresponding author), Rua Pedro de Toledo,669-3rd Floor, BR-04039032 Sao Paulo, SP, Brazil.
EM ana.yamagata@usp.br
RI Brietzke, Elisa/G-9559-2012; Mansur, Rodrigo/N-7131-2019; McIntyre,
   Roger/AAU-1000-2020; Rosenstock, Tatiana/N-1949-2013; Rizzo,
   Lucas/C-5418-2013; Rosenstock, Tatiana/HME-1849-2023
OI Yamagata, Ana Sayuri/0000-0002-6919-6369; Rosenstock,
   Tatiana/0000-0003-1153-7412
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NR 133
TC 21
Z9 22
U1 0
U2 14
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0149-7634
EI 1873-7528
J9 NEUROSCI BIOBEHAV R
JI Neurosci. Biobehav. Rev.
PD JAN
PY 2017
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BP 43
EP 49
DI 10.1016/j.neubiorev.2016.11.010
PG 7
WC Behavioral Sciences; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Behavioral Sciences; Neurosciences & Neurology
GA EI8WW
UT WOS:000392789900004
PM 27871787
DA 2025-06-11
ER

PT J
AU Burton, WN
   Edington, DW
   Schultz, AB
AF Burton, Wayne N.
   Edington, Dee W.
   Schultz, Alyssa B.
TI Lifestyle Medicine and Worker Productivity
SO AMERICAN JOURNAL OF LIFESTYLE MEDICINE
LA English
DT Article
DE health risks; interventions; lifestyle medicine; productivity
ID BODY-MASS INDEX; HEALTH-CARE COSTS; METABOLIC SYNDROME;
   PHYSICAL-ACTIVITY; WORKPLACE HEALTH; EMPLOYEE HEALTH; ECONOMIC COSTS;
   SMOKING STATUS; MENTAL-HEALTH; ASSOCIATION
AB The issue of employee productivity has become a major concern for companies. Inefficiency can occur at every stage of production either as poor design, worker limitation, or other factors. It is generally assumed that a healthy worker is more productive than an unhealthy worker. As early as 1776 Adam Smith observed and published in The Wealth of Nations that poor worker health was a detriment to industrial productivity. The objective of this article is to review the literature documenting the gain or loss of productivity related to the health of workers, as well as any lifestyle management strategies that can be used to improve employee health and productivity. The impact of employee obesity, smoking, physical activity, sleep, and behavioral health on productivity will be explored. By identifying and addressing health risks that impair worker performance, lifestyle medicine professionals can demonstrate a significant return on investment by creating a healthier and more productive work force.
C1 [Burton, Wayne N.] Univ Illinois, Chicago, IL USA.
   [Edington, Dee W.] Edington Associates, Ann Arbor, MI USA.
   [Schultz, Alyssa B.] NCRC, Global Hlth Management Res Core, Bldg 520,1600 Huron Pkwy, Ann Arbor, MI 48109 USA.
C3 University of Illinois System; University of Illinois Chicago;
   University of Illinois Chicago Hospital
RP Schultz, AB (corresponding author), NCRC, Global Hlth Management Res Core, Bldg 520,1600 Huron Pkwy, Ann Arbor, MI 48109 USA.
EM abelaire@umich.edu
OI Schultz, Alyssa/0000-0001-8149-066X
CR [Anonymous], MENT HLTH MENT HLTH
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NR 43
TC 5
Z9 5
U1 2
U2 19
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1559-8276
EI 1559-8284
J9 AM J LIFESTYLE MED
JI Am. J. Lifestyle Med.
PD MAR
PY 2021
VL 15
IS 2
BP 136
EP 139
AR 1559827620948008
DI 10.1177/1559827620948008
EA AUG 2020
PG 4
WC Public, Environmental & Occupational Health
WE Emerging Sources Citation Index (ESCI)
SC Public, Environmental & Occupational Health
GA QV8SF
UT WOS:000561091100001
PM 33790700
OA Green Published
DA 2025-06-11
ER

PT J
AU Svartberg, J
   Agledahl, I
   Figenschau, Y
   Sildnes, T
   Waterloo, K
   Jorde, R
AF Svartberg, J.
   Agledahl, I.
   Figenschau, Y.
   Sildnes, T.
   Waterloo, K.
   Jorde, R.
TI Testosterone treatment in elderly men with subnormal testosterone levels
   improves body composition and BMD in the hip
SO INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH
LA English
DT Article
DE testosterone; hypogonadism; treatment; elderly; body composition
ID MIDDLE-AGED MEN; BONE-MINERAL DENSITY; QUALITY-OF-LIFE; OLDER MEN;
   BIOAVAILABLE TESTOSTERONE; TRANSDERMAL TESTOSTERONE; METABOLIC SYNDROME;
   EXOGENOUS TESTOSTERONE; ANDROGEN DEFICIENCY; SERUM TESTOSTERONE
AB Our intention was to examine if subnormal testosterone levels in older men were associated with a reduction in quality of life and physical and mental health, and secondly to examine if testosterone treatment could improve these conditions. We performed a nested case-control study and a 1-year testosterone intervention study. Men with subnormal testosterone had significantly higher weight, fat mass and abdominal adipose tissue. They also had significantly higher glucose and insulin levels, and they had higher triglyceride levels. Testosterone treatment had a large impact on body composition with reduced fat mass and abdominal adipose tissue and increased fat-free mass, but it did not affect weight and glucose and lipid metabolism. Bone mineral density in the hip was significantly higher after the testosterone treatment. Older men with subnormal testosterone levels had an unfavorable metabolic profile. Testosterone treatment improved body composition, but it did not reverse the unfavorable metabolic profile.
C1 [Svartberg, J.; Agledahl, I.; Jorde, R.] Univ Hosp N Norway, Dept Med, N-9038 Tromso, Norway.
   [Svartberg, J.; Jorde, R.] Univ Tromso, Inst Clin Med, Tromso, Norway.
   [Figenschau, Y.] Univ Hosp N Norway, Dept Med Biochem, N-9038 Tromso, Norway.
   [Figenschau, Y.] Univ Tromso, Dept Med Biochem, Tromso, Norway.
   [Sildnes, T.] Univ Hosp N Norway, Dept Radiol, N-9038 Tromso, Norway.
   [Waterloo, K.] Univ Hosp N Norway, Dept Neurol, N-9038 Tromso, Norway.
   [Waterloo, K.] Univ Tromso, Dept Psychol, Tromso, Norway.
C3 UiT The Arctic University of Tromso; University Hospital of North
   Norway; UiT The Arctic University of Tromso; UiT The Arctic University
   of Tromso; University Hospital of North Norway; UiT The Arctic
   University of Tromso; UiT The Arctic University of Tromso; University
   Hospital of North Norway; UiT The Arctic University of Tromso;
   University Hospital of North Norway; UiT The Arctic University of Tromso
RP Svartberg, J (corresponding author), Univ Hosp N Norway, Dept Med, N-9038 Tromso, Norway.
EM johan.svartberg@unn.no
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NR 32
TC 130
Z9 136
U1 0
U2 2
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0955-9930
J9 INT J IMPOT RES
JI Int. J. Impot. Res.
PD JUL
PY 2008
VL 20
IS 4
BP 378
EP 387
DI 10.1038/ijir.2008.19
PG 10
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 326HB
UT WOS:000257648100006
PM 18480825
DA 2025-06-11
ER

PT J
AU Barbagallo, M
   Belvedere, M
   Dominguez, LJ
AF Barbagallo, Mario
   Belvedere, Mario
   Dominguez, Ligia J.
TI Magnesium homeostasis and aging
SO MAGNESIUM RESEARCH
LA English
DT Review
DE magnesium; aging; Mg deficiency; anti-aging; oxidative stress; chronic
   inflammation; diabetes; hypertension; dementia
ID C-REACTIVE PROTEIN; TYPE-2 DIABETES-MELLITUS; DIETARY MAGNESIUM;
   INTRACELLULAR MAGNESIUM; METABOLIC SYNDROME; RAT MODEL;
   INTESTINAL-ABSORPTION; PARATHYROID-HORMONE; GLUCOSE-METABOLISM;
   ENDOTHELIAL-CELLS
AB Aging is very often associated with magnesium (Mg) deficit. Total plasma magnesium concentrations are remarkably constant in healthy subjects throughout life, while total body Mg and Mg in the intracellular compartment tend to decrease with age. Dietary Mg deficiencies are common in the elderly population. Other frequent causes of Mg deficits in the elderly include reduced Mg intestinal absorption, reduced Mg bone stores, and excess urinary loss. Secondary Mg deficit in aging may result from different conditions and diseases often observed in the elderly (i.e. insulin resistance and/or type 2 diabetes mellitus) and drugs (i.e. use of hypermagnesuric diuretics). Chronic Mg deficits have been linked to an increased risk of numerous preclinical and clinical outcomes, mostly observed in the elderly population, including hypertension, stroke, atherosclerosis, ischemic heart disease, cardiac arrhythmias, glucose intolerance, insulin resistance, type 2 diabetes mellitus, endothelial dysfunction, vascular remodeling, alterations in lipid metabolism, platelet aggregation/thrombosis, inflammation, oxidative stress, cardiovascular mortality, asthma, chronic fatigue, as well as depression and other neuropsychiatric disorders. Both aging and Mg deficiency have been associated to excessive production of oxygen-derived free radicals and low-grade inflammation. Chronic inflammation and oxidative stress are also present in several age-related diseases, such as many vascular and metabolic conditions, as well as frailty, muscle loss and sarcopenia, and altered immune responses, among others. Mg deficit associated to aging may be at least one of the pathophysiological links that may help to explain the interactions between inflammation and oxidative stress with the aging process and many age-related diseases.
C1 [Barbagallo, Mario; Belvedere, Mario; Dominguez, Ligia J.] Univ Palermo, Geriatr Unit, Dept Internal Med & Emergent Pathol, I-90133 Palermo, Italy.
C3 University of Palermo
RP Barbagallo, M (corresponding author), Viale F Scaduto 6-C, I-90144 Palermo, Italy.
EM mabar@unipa.it
RI ; BARBAGALLO, MARIO/K-4794-2017
OI dominguez, ligia j/0000-0003-1466-8610; BARBAGALLO,
   MARIO/0000-0002-1349-6530
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NR 85
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PU JOHN LIBBEY EUROTEXT LTD
PI MONTROUGE
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J9 MAGNESIUM RES
JI Magnes. Res.
PD DEC
PY 2009
VL 22
IS 4
BP 235
EP 246
DI 10.1684/mrh.2009.0187
PG 12
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 536UZ
UT WOS:000273070700002
PM 20228001
DA 2025-06-11
ER

PT J
AU Sibiya, T
   Ghazi, T
   Chuturgoon, A
AF Sibiya, Thabani
   Ghazi, Terisha
   Chuturgoon, Anil
TI The Potential of Spirulina platensis to Ameliorate the Adverse
   Effects of Highly Active Antiretroviral Therapy (HAART)
SO NUTRIENTS
LA English
DT Review
DE HAART; ARVs; Spirulina platensis; oxidative stress; HIV; antioxidant;
   inflammation; HAART toxicity; MetS
ID HUMAN-IMMUNODEFICIENCY-VIRUS; IN-VITRO EVALUATION; TENOFOVIR DISOPROXIL
   FUMARATE; HIV PREEXPOSURE PROPHYLAXIS; INDUCED OXIDATIVE STRESS;
   NF-KAPPA-B; C-PHYCOCYANIN; ANTIINFLAMMATORY ACTIVITY; METABOLIC
   SYNDROME; ANTIOXIDANT ACTIVITY
AB The human immunodeficiency virus (HIV) is one of the most prevalent diseases globally. It is estimated that 37.7 million people are infected with HIV globally, and 8.2 million persons are infected with the virus in South Africa. The highly active antiretroviral therapy (HAART) involves combining various types of antiretroviral drugs that are dependent on the infected person's viral load. HAART helps regulate the viral load and prevents its associated symptoms from progressing into acquired immune deficiency syndrome (AIDS). Despite its success in prolonging HIV-infected patients' lifespans, the use of HAART promotes metabolic syndrome (MetS) through an inflammatory pathway, excess production of reactive oxygen species (ROS), and mitochondrial dysfunction. Interestingly, Spirulina platensis (SP), a blue-green microalgae commonly used as a traditional food by Mexican and African people, has been demonstrated to mitigate MetS by regulating oxidative and inflammatory pathways. SP is also a potent antioxidant that has been shown to exhibit immunological, anticancer, anti-inflammatory, anti-aging, antidiabetic, antibacterial, and antiviral properties. This review is aimed at highlighting the biochemical mechanism of SP with a focus on studies linking SP to the inhibition of HIV, inflammation, and oxidative stress. Further, we propose SP as a potential supplement for HIV-infected persons on lifelong HAART.
C1 [Sibiya, Thabani; Ghazi, Terisha; Chuturgoon, Anil] Univ KwaZulu Natal, Coll Hlth Sci, Sch Lab Med & Med Sci, Discipline Med Biochem & Chem Pathol, Howard Coll Campus, ZA-4013 Durban, South Africa.
C3 University of Kwazulu Natal
RP Chuturgoon, A (corresponding author), Univ KwaZulu Natal, Coll Hlth Sci, Sch Lab Med & Med Sci, Discipline Med Biochem & Chem Pathol, Howard Coll Campus, ZA-4013 Durban, South Africa.
EM thabani585@gmail.com; terishaghazi@gmail.com; chutur@ukzn.ac.za
RI Ghazi, Terisha/AAU-5164-2021; Chuturgoon, Anil/AAE-5068-2021
OI Ghazi, Terisha/0000-0002-0179-213X; Sibiya, Thabani/0000-0001-6648-2813
FU National Research Foundation Innovation Doctoral Scholarship [130023];
   University of KwaZulu Natal, College of Health Sciences Masters and
   Doctoral Research Scholarship
FX Grant sponsor: National Research Foundation Innovation Doctoral
   Scholarship; Grant number: 130023; Grant sponsor: University of KwaZulu
   Natal, College of Health Sciences Masters and Doctoral Research
   Scholarship.
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NR 190
TC 9
Z9 9
U1 1
U2 14
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD AUG
PY 2022
VL 14
IS 15
AR 3076
DI 10.3390/nu14153076
PG 17
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 3S6KP
UT WOS:000839703600001
PM 35893930
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Mi, YS
   Qi, GY
   Gao, YQ
   Li, RN
   Wang, YW
   Li, XY
   Huang, SX
   Liu, XB
AF Mi, Yashi
   Qi, Guoyuan
   Gao, Yuqi
   Li, Runnan
   Wang, Yiwen
   Li, Xingyu
   Huang, Shuxian
   Liu, Xuebo
TI (-)-Epigallocatechin-3-gallate Ameliorates Insulin Resistance and
   Mitochondrial Dysfunction in HepG2 Cells: Involvement of Bmal1
SO MOLECULAR NUTRITION & FOOD RESEARCH
LA English
DT Article
DE circadian clock; (-)-epigallocatechin-3-gallate; insulin resistance;
   mitochondrial function; oxidative stress
ID HIGH-FAT DIET; INDUCED OXIDATIVE STRESS; GREEN TEA POLYPHENOL; METABOLIC
   SYNDROME; CIRCADIAN-RHYTHMS; LIVER-DISEASE; GLUCOSE-HOMEOSTASIS;
   ABDOMINAL OBESITY; CANCER-CELLS; MICE
AB Scope Normal physiological processes require a robust biological timer called the circadian clock. Dysregulation of circadian rhythms contributes to a variety of metabolic syndrome, including obesity and insulin resistance. (-)-Epigallocatechin-3-gallate (EGCG) has been demonstrated to possess antioxidant, anti-inflammatory, and cardioprotective bioactivities. The objective of this study was to explore whether the circadian clock is involved in the protective effect of EGCG against insulin resistance.
   Methods and results The results demonstrated that EGCG reverses the relatively shallow daily oscillations of circadian clock genes transcription and protein expression induced by glucosamine in HepG2 cells. EGCG also alleviates insulin resistance by enhancing tyrosine phosphorylated levels of IRS-1, stimulating the translocation of GLUT2, and activating PI3K/AKT as well as AMPK signaling pathways in a Bmal1-dependent manner both in HepG2 cells and primary hepatocytes. Glucosamine-stimulated excessive secretions of ROS and depletions of mitochondrial membrane potential were notably attenuated in EGCG co-treated HepG2 cells, which consistent with the recovery in expression of mitochondrial respiration complexes.
   Conclusion The results demonstrated that EGCG possesses a Bmal1-dependent efficacy against insulin resistance conditions by strengthening the insulin signaling and eliminating oxidative stress, suggesting that EGCG may serve as a promising natural nutraceutical for the regulation of metabolic disorders relevant to circadian clocks.
C1 [Mi, Yashi; Qi, Guoyuan; Gao, Yuqi; Li, Runnan; Wang, Yiwen; Li, Xingyu; Huang, Shuxian; Liu, Xuebo] Northwest A&F Univ, Coll Food Sci & Engn, Lab Funct Chem & Nutr Food, Yangling, Shaanxi, Peoples R China.
C3 Northwest A&F University - China
RP Liu, XB (corresponding author), Northwest A&F Univ, Coll Food Sci & Engn, Lab Funct Chem & Nutr Food, Yangling, Shaanxi, Peoples R China.
EM xueboliu@aliyun.com
RI /AAZ-9695-2020
OI Li., Runnan/0009-0007-6655-2325
FU National Natural Science Foundation of China [31571842]; National Key
   Research and Development Program of China [2016YFD0400601]
FX This work was financially supported by the National Natural Science
   Foundation of China (No. 31571842) and the National Key Research and
   Development Program of China (No. 2016YFD0400601).
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NR 57
TC 52
Z9 53
U1 4
U2 93
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1613-4125
EI 1613-4133
J9 MOL NUTR FOOD RES
JI Mol. Nutr. Food Res.
PD DEC
PY 2017
VL 61
IS 12
AR 1700440
DI 10.1002/mnfr.201700440
PG 15
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA FP2PC
UT WOS:000417459400016
PM 28869341
DA 2025-06-11
ER

PT J
AU Nunn, AVW
   Bell, JD
   Guy, GW
AF Nunn, Alistair V. W.
   Bell, Jimmy D.
   Guy, Geoffrey W.
TI Lifestyle-induced metabolic inflexibility and accelerated ageing
   syndrome: insulin resistance, friend or foe?
SO NUTRITION & METABOLISM
LA English
DT Review
ID ACTIVATED PROTEIN-KINASE; NF-KAPPA-B; TRANSCRIPTION FACTOR FOXO1;
   ENDOPLASMIC-RETICULUM STRESS; PROMOTES MITOCHONDRIAL BIOGENESIS;
   POLYUNSATURATED FATTY-ACIDS; HIGH-DENSITY-LIPOPROTEIN; VISCERAL
   ADIPOSE-TISSUE; NITRIC-OXIDE SYNTHASE; ACUTE-PHASE REACTANTS
AB The metabolic syndrome may have its origins in thriftiness, insulin resistance and one of the most ancient of all signalling systems, redox. Thriftiness results from an evolutionarily-driven propensity to minimise energy expenditure. This has to be balanced with the need to resist the oxidative stress from cellular signalling and pathogen resistance, giving rise to something we call 'redox-thriftiness'. This is based on the notion that mitochondria may be able to both amplify membrane-derived redox growth signals as well as negatively regulate them, resulting in an increased ATP/ROS ratio. We suggest that 'redox-thriftiness' leads to insulin resistance, which has the effect of both protecting the individual cell from excessive growth/inflammatory stress, while ensuring energy is channelled to the brain, the immune system, and for storage. We also suggest that fine tuning of redox-thriftiness is achieved by hormetic (mild stress) signals that stimulate mitochondrial biogenesis and resistance to oxidative stress, which improves metabolic flexibility. However, in a non-hormetic environment with excessive calories, the protective nature of this system may lead to escalating insulin resistance and rising oxidative stress due to metabolic inflexibility and mitochondrial overload. Thus, the mitochondrially-associated resistance to oxidative stress (and metabolic flexibility) may determine insulin resistance. Genetically and environmentally determined mitochondrial function may define a 'tipping point' where protective insulin resistance tips over to inflammatory insulin resistance. Many hormetic factors may induce mild mitochondrial stress and biogenesis, including exercise, fasting, temperature extremes, unsaturated fats, polyphenols, alcohol, and even metformin and statins. Without hormesis, a proposed redox-thriftiness tipping point might lead to a feed forward insulin resistance cycle in the presence of excess calories. We therefore suggest that as oxidative stress determines functional longevity, a rather more descriptive term for the metabolic syndrome is the 'lifestyle-induced metabolic inflexibility and accelerated ageing syndrome'. Ultimately, thriftiness is good for us as long as we have hormetic stimuli; unfortunately, mankind is attempting to remove all hormetic (stressful) stimuli from his environment.
C1 [Nunn, Alistair V. W.; Bell, Jimmy D.] Univ London Imperial Coll Sci Technol & Med, Hammersmith Hosp, MRC Clin Sci Ctr, Metab & Mol Imaging Grp, London W12 OHS, England.
   [Guy, Geoffrey W.] GW Pharmaceut, Porton Down, Dorset, England.
C3 Imperial College London
RP Nunn, AVW (corresponding author), Univ London Imperial Coll Sci Technol & Med, Hammersmith Hosp, MRC Clin Sci Ctr, Metab & Mol Imaging Grp, Du Cane Rd, London W12 OHS, England.
EM alistair.nunn@btconnect.com; jimmy.bell@csc.mrc.ac.uk; gwg@gwpharm.com
RI Nunn, Alistair/ABE-2462-2020
OI Bell, Jimmy/0000-0003-3804-1281
FU MRC [MC_U120061305] Funding Source: UKRI; Medical Research Council
   [MC_U120061305] Funding Source: Medline
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   2003, WORLD HLTH ORGAN TEC, V916, P149
NR 304
TC 58
Z9 64
U1 0
U2 13
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1743-7075
J9 NUTR METAB
JI Nutr. Metab.
PD APR 16
PY 2009
VL 6
AR 16
DI 10.1186/1743-7075-6-16
PG 26
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 449IS
UT WOS:000266324700001
PM 19371409
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Ekstrand, B
   Scheers, N
   Rasmussen, MK
   Young, JF
   Ross, AB
   Landberg, R
AF Ekstrand, Bo
   Scheers, Nathalie
   Rasmussen, Martin Kroyer
   Young, Jette Feveile
   Ross, Alastair B.
   Landberg, Rikard
TI Brain foods - the role of diet in brain performance and health
SO NUTRITION REVIEWS
LA English
DT Review
DE Brain; diet; signaling; cognition; inflammation; proteostasis;
   epigenetics
ID POLYUNSATURATED FATTY-ACIDS; GREEN TEA POLYPHENOL; LONG-CHAIN
   OMEGA-3-FATTY-ACIDS; MILD COGNITIVE IMPAIRMENT; DIPEPTIDYL-PEPTIDASE IV;
   CENTRAL-NERVOUS-SYSTEM; ALZHEIMERS-DISEASE; VITAMIN-D; AMYLOID-BETA;
   METABOLIC SYNDROME
AB The performance of the human brain is based on an interplay between the inherited genotype and external environmental factors, including diet. Food and nutrition, essential in maintenance of brain performance, also aid in prevention and treatment of mental disorders. Both the overall composition of the human diet and specific dietary components have been shown to have an impact on brain function in various experimental models and epidemiological studies. This narrative review provides an overview of the role of diet in 5 key areas of brain function related to mental health and performance, including: (1) brain development, (2) signaling networks and neurotransmitters in the brain, (3) cognition and memory, (4) the balance between protein formation and degradation, and (5) deteriorative effects due to chronic inflammatory processes. Finally, the role of diet in epigenetic regulation of brain physiology is discussed.
C1 [Ekstrand, Bo; Scheers, Nathalie; Ross, Alastair B.; Landberg, Rikard] Chalmers Univ Technol, Dept Biol & Biol Engn Food & Nutr Sci, Gothenburg, Sweden.
   [Rasmussen, Martin Kroyer; Young, Jette Feveile] Aarhus Univ, Dept Food Sci, Agro Food Pk 48, DK-8200 Aarhus N, Denmark.
   [Ross, Alastair B.] AgResearch, Lincoln, New Zealand.
C3 Chalmers University of Technology; Aarhus University; AgResearch - New
   Zealand
RP Rasmussen, MK (corresponding author), Aarhus Univ, Dept Food Sci, Agro Food Pk 48, DK-8200 Aarhus N, Denmark.
EM Martink.rasmussen@food.au.dk
RI Young, Jette/AET-5065-2022; Rasmussen, Martin/AAE-8454-2019
OI Young, Jette Feveile/0000-0002-8809-9513; Rasmussen, Martin
   Kroyer/0000-0002-1889-2874
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NR 312
TC 32
Z9 32
U1 4
U2 56
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0029-6643
EI 1753-4887
J9 NUTR REV
JI Nutr. Rev.
PD JUN
PY 2021
VL 79
IS 6
BP 693
EP 708
DI 10.1093/nutrit/nuaa091
PG 16
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nutrition & Dietetics
GA SS1WS
UT WOS:000661533900004
PM 32989449
DA 2025-06-11
ER

PT J
AU Badescu, GM
   Fîlfan, M
   Ciobanu, O
   Dumbrava, DA
   Popa-Wagner, A
AF Badescu, George Mihai
   Filfan, Madalina
   Ciobanu, Ovidiu
   Dumbrava, Danut-Adrian
   Popa-Wagner, Aurel
TI Age-related hypoxia in CNS pathology
SO ROMANIAN JOURNAL OF MORPHOLOGY AND EMBRYOLOGY
LA English
DT Review
DE cerebral ischemia; depression; cognition; post-stroke dementia
ID C-REACTIVE PROTEIN; BODY-MASS INDEX; INCREASED CYTOKINE PRODUCTION;
   MAJOR DEPRESSIVE DISORDER; LATE-LIFE DEPRESSION; ADIPOSE-TISSUE;
   INFLAMMATORY RESPONSE; METABOLIC SYNDROME; CEREBRAL HYPOPERFUSION;
   COGNITIVE IMPAIRMENT
AB Although neuropathological conditions differ in the etiology of the inflammatory response, cellular and molecular mechanisms of neuro-inflammation are probably similar in aging, hypertension, depression and cognitive impairment. Moreover, a number of common risk factors such as obesity, hypertension, diabetes and atherosclerosis are increasingly understood to act as "silent contributors" to neuroinflammation and can underlie the development of disorders such as cerebral small vessel disease (cSVD) and subsequent dementia. On the other hand, acute neuroinflammation, such as in response to traumatic or cerebral ischemia, aggravates the acute damage and can lead to a number of pathological such as depression, post-stroke dementia and potentially neurodegeneration. All of those sequelae impair recovery and most of them provide the ground for further cerebrovascular events and a vicious cycle develops. Therefore, understanding the mechanisms associated with vascular dementia, stroke and related complications is of paramount importance in improving current preventive and therapeutic interventions. Likewise, understanding of molecular factors and pathways associated with neuroinflammation will eventually enable the discovery and implementation of new diagnostic and therapeutic strategies indicated in a wide range of neurological conditions.
C1 [Badescu, George Mihai] Univ Med & Pharm Craiova, Psychiat Clin Hosp 2, Craiova, Romania.
   [Filfan, Madalina; Ciobanu, Ovidiu; Dumbrava, Danut-Adrian; Popa-Wagner, Aurel] Univ Med & Pharm Craiova, Ctr Clin & Expt Med, Dept Funct Sci, Craiova, Romania.
   [Popa-Wagner, Aurel] Univ Med Rostock, Dept Psychiat, Gehlsheimer Str 20, D-18147 Rostock, Germany.
C3 University of Medicine & Pharmacy of Craiova; University of Medicine &
   Pharmacy of Craiova; University of Rostock
RP Popa-Wagner, A (corresponding author), Univ Med Rostock, Dept Psychiat, Gehlsheimer Str 20, D-18147 Rostock, Germany.
EM aurel.popa-wagner@med.uni-rostock.de
RI Filfan/Aldea, Madalina/AAG-2450-2021; Popa-Wagner, Aurel/E-2541-2013;
   Dumbrava, Danut-Adrian/L-2816-2018
OI Popa-Wagner, Aurel/0000-0003-4574-8605; Dumbrava,
   Danut-Adrian/0000-0003-4208-4452; Aldea/Filfan,
   Madalina/0000-0003-0543-3596
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NR 157
TC 4
Z9 4
U1 0
U2 14
PU EDITURA ACAD ROMANE
PI BUCURESTI
PA CALEA 13 SEPTEMBRIE NR 13, SECTOR 5, BUCURESTI 050711, ROMANIA
SN 1220-0522
EI 2066-8279
J9 ROM J MORPHOL EMBRYO
JI Rom. J. Morphol. Embryol.
PY 2016
VL 57
IS 1
BP 33
EP 43
PG 11
WC Developmental Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Developmental Biology
GA DM0PR
UT WOS:000376048800003
PM 27151686
DA 2025-06-11
ER

PT J
AU Aouira, N
   Khan, S
   McDermott, B
   Heussler, H
   Haywood, A
   Karaksha, A
   Bor, W
AF Aouira, Nisreen
   Khan, Sohil
   McDermott, Brett
   Heussler, Helen
   Haywood, Alison
   Karaksha, Abdullah
   Bor, William
TI Paper based vs. electronic records for clinical audit: Evidence of
   documentation of medication safety monitoring in youth prescribed
   antipsychotics
SO CHILDREN AND YOUTH SERVICES REVIEW
LA English
DT Article
ID METABOLIC SYNDROME; CHILDREN; COMPUTER; ADOLESCENTS; DRUGS; RISK
AB Background: Since the development of digital records, claims have been made that they improve audits. Clinical audits play important role in evaluation of evidence-practice gaps. Antipsychotic medications are one of the commonly prescribed group of drugs in severe adverse mental conditions. Youth and young people are highly prone to develop drug induced metabolic syndrome. Present study evaluated the extent of data documentation on evidence for metabolic monitoring of anti-psychotics and compared paper based to electronic records with good documentation standards.
   Methods: First phase of this study involved a retrospective clinical audit of paper-based documentation on the extent of documentation of weight (primary outcome); lipid and blood glucose (secondary outcomes) of youth prescribed atypical antipsychotics. This was undertaken in three public mental health clinics and a public/private developmental service in Australia based on paper-based documentation. The second phase included auditing electronic data capture from one community clinic. Evidence of documentation was compared with practice standards and published clinical audits (adherence rate benchmark: 40-60%).
   Results: A total of 310 cases were assessed of which 51 and 37 cases met the eligibility criteria for paper-based and electronic based audit respectively as a component of clinical audit. Evidence of paper documentation of weight was 43% among participants and was comparable with other published clinical audits (p = 0.07) with poor monitoring rates for other blood tests. Findings revealed poor rate of documentation at 35.1% (13 cases), 5.4% (2 cases) and 8.1% (3 cases) for weight, lipid assessments and glucose monitoring, respectively based on electronic records.
   Conclusion: Present study demonstrate lack of good documentation practices on metabolic monitoring of youth prescribed antipsychotics. It appears transitioning from paper to electronic records did not impact the rate of increase in documentation of metabolic monitoring. This study recommends inclusion of e-monitoring icon with built in metabolic monitoring chart as a component of youth prescribed antipsychotic case records. Good documentation practice is a first step in determination of causality of antipsychotics induced metabolic syndrome. Appropriate strategies to a user-friendly electronic reminder system will be crucial to address on the mechanistic of documentation.
C1 [Aouira, Nisreen; Khan, Sohil; Haywood, Alison; Karaksha, Abdullah] Griffith Univ, Sch Pharm & Pharmacol, Menzies Hlth Inst, Gold Coast, Australia.
   [Khan, Sohil; Heussler, Helen; Haywood, Alison; Bor, William] Univ Queensland, Mater Res Inst, South Brisbane, Australia.
   [Khan, Sohil] Manipal Acad Higher Educ, Prasanna Inst Publ Hlth, Manipal, India.
   [Khan, Sohil] Manipal Acad Higher Educ, Manipal Coll Pharmaceut Sci, Manipal, India.
   [McDermott, Brett] James Cook Univ, Townsville Clin Sch, Townsville, Australia.
   [Heussler, Helen; Bor, William] Childrens Hlth Queensland Hosp & Hlth Serv, South Brisbane, Australia.
C3 Menzies Health Institute Queensland; Griffith University; Griffith
   University - Gold Coast Campus; Mater Research; University of
   Queensland; Manipal Academy of Higher Education (MAHE); Manipal Academy
   of Higher Education (MAHE); James Cook University; Childrens Health
   Queensland Hospital & Health Service
RP Khan, S (corresponding author), Griffith Univ, Sch Pharm & Pharmacol, Menzies Hlth Inst, Gold Coast, Australia.; Khan, S (corresponding author), Univ Queensland, Mater Res Inst, South Brisbane, Australia.; Khan, S (corresponding author), Manipal Acad Higher Educ, Prasanna Inst Publ Hlth, Manipal, India.; Khan, S (corresponding author), Manipal Acad Higher Educ, Manipal Coll Pharmaceut Sci, Manipal, India.
EM s.khan@griffith.edu.au
RI Bor, William/J-2215-2015
OI McDermott, Brett/0000-0002-6639-1767; Haywood,
   Alison/0000-0002-5354-8868; Aouira, Nisreen/0000-0001-9297-6737
FU Institutional Funding (Griffith University, Australia)
FX Institutional Funding (Griffith University, Australia).
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NR 44
TC 1
Z9 1
U1 0
U2 5
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0190-7409
EI 1873-7765
J9 CHILD YOUTH SERV REV
JI Child. Youth Serv. Rev.
PD FEB
PY 2020
VL 109
AR 104666
DI 10.1016/j.childyouth.2019.104666
PG 6
WC Family Studies; Social Work
WE Social Science Citation Index (SSCI)
SC Family Studies; Social Work
GA KM6MZ
UT WOS:000514253500008
DA 2025-06-11
ER

PT J
AU Jakubowska-Kowal, K
   Skrzynska, K
   Gawlik-Starzyk, A
AF Jakubowska-Kowal, Karolina
   Skrzynska, Karolina
   Gawlik-Starzyk, Aneta
TI Treatment and complications of PCOS in adolescents - what's new in 2023?
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Article
DE polycystic ovary syndrome; adolescent; oligomenorrhea; hirsutism;
   hyperandrogenism
ID POLYCYSTIC-OVARY-SYNDROME; PREVALENCE; CONSENSUS; OBESITY
AB Polycystic ovary syndrome (PCOS) is a disease affecting as many as about 10% of women of reproductive age, also 3-11% of teenage patients, and can lead to numerous complications and coexists with many diseases. Research is ongoing to establish an appropriate diagnostic and therapeutic path for adolescent girls with PCOS. It is also important to implement appropriate check-ups among teenagers with PCOS in order to prevent PCOS complications and initiate appropriate treatment as soon as possible and prevent the long-term consequences of these complications. The relationship between the co-occurrence of PCOS and diseases such as metabolic syndrome, hypertension, obesity, insulin resistance, type 2 diabetes and non-alcoholic fatty liver disease (NAFLD) is increasingly being investigated. A great attention is also being paid to the problem of mental health in this group of patients. In our study, we will review the latest reports on the treatment of PCOS and look at the complications that this syndrome can cause.
C1 [Jakubowska-Kowal, Karolina; Skrzynska, Karolina; Gawlik-Starzyk, Aneta] Med Univ Silesia, Dept Pediat & Pediat Endocrinol, Katowice, Poland.
C3 Medical University of Silesia
RP Jakubowska-Kowal, K (corresponding author), Med Univ Silesia, Dept Pediat & Pediat Endocrinol, Katowice, Poland.
EM kjakubowskakowal@gmail.com
FX The author(s) declare financial support was received for the research,
   authorship, and/or publication of this article. The publication fee was
   covered by the Medical University of Silesia in Katowice
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NR 38
TC 0
Z9 0
U1 5
U2 5
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD OCT 2
PY 2024
VL 15
AR 1436952
DI 10.3389/fendo.2024.1436952
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA I8Z0L
UT WOS:001333069400001
PM 39415788
OA gold
DA 2025-06-11
ER

PT J
AU Numakawa, T
   Richards, M
   Nakajima, S
   Adachi, N
   Furuta, M
   Odaka, H
   Kunugi, H
AF Numakawa, Tadahiro
   Richards, Misty
   Nakajima, Shingo
   Adachi, Naoki
   Furuta, Miyako
   Odaka, Haruki
   Kunugi, Hiroshi
TI The role of brain-derived neurotrophic factor in comorbid depression:
   possible linkage with steroid hormones, cytokines, and nutrition
SO FRONTIERS IN PSYCHIATRY
LA English
DT Review
DE depression; BDNF; glucocorticoid; estrogen; cytokines; obesity;
   flavonoids
ID PITUITARY-ADRENAL AXIS; ESTROGEN-RECEPTOR-BETA; NECROSIS-FACTOR-ALPHA;
   HIGH-FAT; SYNAPTIC PLASTICITY; VAL66MET POLYMORPHISM; HIPPOCAMPAL
   PLASTICITY; METABOLIC SYNDROME; BDNF; ZINC
AB Increasing evidence demonstrates a connection between growth factor function (including brain-derived neurotrophic factor, BDNF), glucocorticoid levels (one of the steroid hormones), and the pathophysiology of depressive disorders. Because both BDNF and glucocorticoids regulate synaptic function in the central nervous system, their functional interaction is of major concern. Interestingly, alterations in levels of estrogen, another steroid hormone, may play a role in depressive-like behavior in postpartum females with fluctuations of BDNF-related molecules in the brain. BDNF and cytokines, which are protein regulators of inflammation, stimulate multiple intracellular signaling cascades involved in neuropsychiatric illness. Pro-inflammatory cytokines may increase vulnerability to depressive symptoms, such as the increased risk observed in patients with cancer and/or autoimmune diseases. In this review, we discuss the possible relationship between inflammation and depression, in addition to the cross-talk among cytokines, BDNF, and steroids. Further, since nutritional status has been shown to affect critical pathways involved in depression through both BDNF function and the monoamine system, we also review current evidence surrounding diet and supplementation (e.g., flavonoids) on BDNF-mediated brain functions.
C1 [Numakawa, Tadahiro; Nakajima, Shingo; Adachi, Naoki; Odaka, Haruki; Kunugi, Hiroshi] Natl Inst Neurosci, Natl Ctr Neurol & Psychiat, Dept Mental Disorder Res, 4-1-1 Ogawa Higashi, Kodaira, Tokyo, Japan.
   [Richards, Misty] Univ Calif Los Angeles, Semel Inst Neurosci & Human Behav, Los Angeles, CA USA.
   [Furuta, Miyako] St Marianna Univ, Sch Med, Dept Physiol, Kawasaki, Kanagawa, Japan.
C3 National Center for Neurology & Psychiatry - Japan; University of
   California System; University of California Los Angeles; Saint Marianna
   University
RP Numakawa, T (corresponding author), Natl Inst Neurosci, Natl Ctr Neurol & Psychiat, Dept Mental Disorder Res, 4-1-1 Ogawa Higashi, Kodaira, Tokyo, Japan.
EM numakawa@ncnp.go.jp
RI Odaka, Haruki/AAQ-4448-2020; Kunugi, Hiroshi/ABC-5260-2021; Richards,
   Misty/JVN-6897-2024
OI Adachi, Naoki/0000-0002-4850-1467; Kunugi, Hiroshi/0000-0002-7209-3790;
   Odaka, Haruki/0000-0001-5632-2680
FU Health and Labor Sciences Research Grants (Comprehensive Research on
   Disability, Health, and Welfare) [H21-kokoro-002]; Intramural Research
   Grant for Neurological and Psychiatric Disorders of NCNP [24-11]; Takeda
   Science Foundation; JSPS KAKENHI from the Ministry of Education,
   Culture, Sports, Science, and Technology of Japan [24300139, 25640019]
FX This study was supported by the Health and Labor Sciences Research
   Grants (Comprehensive Research on Disability, Health, and Welfare
   H21-kokoro-002) (Hiroshi Kunugi), Intramural Research Grant (No. 24-11)
   for Neurological and Psychiatric Disorders of NCNP (Hiroshi Kunugi), and
   Takeda Science Foundation (Tadahiro Numakawa). This is also supported by
   a grant from the Grant-in-Aid for Scientific Research (B) (JSPS KAKENHI
   Grant Number 24300139) (Tadahiro Numakawa) and for Challenging
   Exploratory Research (JSPS KAKENHI Grant Number 25640019) (Tadahiro
   Numakawa) from the Ministry of Education, Culture, Sports, Science, and
   Technology of Japan.
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NR 140
TC 70
Z9 76
U1 2
U2 24
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-0640
J9 FRONT PSYCHIATRY
JI Front. Psychiatry
PD SEP 26
PY 2014
VL 5
AR 136
DI 10.3389/fpsyt.2014.00136
PG 12
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA V46WA
UT WOS:000209913100001
PM 25309465
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Gaston, SA
   Park, YM
   McWhorter, KL
   Sandler, DP
   Jackson, CL
AF Gaston, Symielle A.
   Park, Yong-Moon
   McWhorter, Ketrell L.
   Sandler, Dale P.
   Jackson, Chandra L.
TI Multiple poor sleep characteristics and metabolic abnormalities
   consistent with metabolic syndrome among white, black, and
   Hispanic/Latina women: modification by menopausal status
SO DIABETOLOGY & METABOLIC SYNDROME
LA English
DT Article
DE Metabolic syndrome; Sleep; African Americans; Hispanic Americans;
   Whites; Women; Menopause
ID PHYSICAL-ACTIVITIES; DURATION; QUALITY; ASSOCIATION; PREVALENCE; ADULTS;
   RISK; RECOMMENDATIONS; DISPARITIES; MANAGEMENT
AB Poor sleep is a potential risk factor for metabolic syndrome (MetS), and its relationship with MetS may vary by race/ethnicity and menopausal status among women.
   We used Sister Study enrollment data from 2003 to 2009 to investigate the cross-sectional associations between multiple subjective sleep characteristics and having ae 3 prevalent metabolic abnormalities consistent with MetS among white, black, and Hispanic/Latina women. Self-reported sleep characteristics included average sleep duration (short [< 7 h] vs. recommended [7-9 h]), sleep debt (ae 2-h difference between shortest and longest sleep duration, napping ae<yen> 3 times/week, and insomnia symptoms (difficulty falling or staying asleep). We used Poisson regression with robust variance to estimate adjusted prevalence ratios (PRs) and 95% confidence intervals (CIs) to compare MetS prevalence between women with poor sleep (e.g., short sleep, sleep debt, frequent napping, or insomnia symptoms [all yes vs. no]) and non-poor sleep within menopausal status categories (premenopausal or postmenopausal). We adjusted for sociodemographic characteristics, mental health, and health behaviors.
   Among 38,007 eligible women (13,988 premenopausal, 24,019 postmenopausal), mean age was 55 +/- 8.8 years, racial/ethnic composition was 86.63% white, 8.53% black, and 4.84% Hispanic/Latina, and 12% had MetS. Associations between certain poor sleep characteristics [i.e., short sleep (PRpremenopausal = 1.23 [95% CI 1.06-1.42], PRpostmenopausal = 1.09 [1.02-1.16], p(short sleep*menopause) = 0.0070) and insomnia symptoms (PRpremenopausal = 1.21 [1.05-1.41], PRpostmenopausal = 1.11 [1.05-1.18], p(insomnia symptoms*menopause) = 0.035)] and prevalent MetS were stronger among premenopausal compared to postmenopausal women, but did not vary by race/ethnicity. Associations between concurrent short sleep/insomnia symptoms and MetS were stronger among white and Hispanic/Latina postmenopausal women compared to their black counterparts. Menopausal status and race/ethnicity did not modify positive associations for other poor sleep characteristics.
   Poor sleep was positively associated with MetS prevalence. Associations between individual poor sleep characteristics (i.e., short sleep, insomnia symptoms) were stronger among premenopausal compared to postmenopausal women but did not vary by race/ethnicity.
C1 [Gaston, Symielle A.; Park, Yong-Moon; McWhorter, Ketrell L.; Sandler, Dale P.; Jackson, Chandra L.] NIEHS, Epidemiol Branch, Dept Hlth & Human Serv, NIH, Res Triangle Pk, NC 27709 USA.
   [Jackson, Chandra L.] Natl Inst Minor Hlth & Hlth Dispar, Intramural Program, US Dept HHS, NIH, Bethesda, MD USA.
C3 National Institutes of Health (NIH) - USA; NIH National Institute of
   Environmental Health Sciences (NIEHS); National Institutes of Health
   (NIH) - USA; NIH National Institute on Minority Health & Health
   Disparities (NIMHD)
RP Jackson, CL (corresponding author), NIEHS, Epidemiol Branch, Dept Hlth & Human Serv, NIH, Res Triangle Pk, NC 27709 USA.
EM symielle.gaston@nih.gov; mark.park@nih.gov; ketrell.mcwhorter@nih.gov;
   sandler@niehs.nih.gov; chandra.jackson@nih.gov
RI Gaston, Symielle/R-2695-2019; Sandler, Dale/E-5110-2019; PARK, YONG-MOON
   ("MARK")/ABA-2765-2021; Jackson, Chandra/A-6291-2017
OI Sandler, Dale/0000-0002-6776-0018; Gaston, Symielle/0000-0001-9495-1592;
   Jackson, Chandra/0000-0002-0915-8272; PARK, YONG-MOON
   ("MARK")/0000-0002-5879-6879
FU Intramural Program at the NIH, National Institute of Environmental
   Health Sciences [Z1AES103325-01, Z01ES044005]; National Institute of
   Environmental Health Sciences [ZIAES103325] Funding Source: NIH RePORTER
FX This work was funded by the Intramural Program at the NIH, National
   Institute of Environmental Health Sciences [Z1AES103325-01 (CLJ) and
   Z01ES044005 (DPS)].
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NR 48
TC 30
Z9 32
U1 0
U2 6
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1758-5996
J9 DIABETOL METAB SYNDR
JI Diabetol. Metab. Syndr.
PD FEB 14
PY 2019
VL 11
AR 17
DI 10.1186/s13098-019-0413-2
PG 13
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA HL9TS
UT WOS:000459086100001
PM 30815038
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Venturini, D
   Simao, ANC
   Urbano, MR
   Dichi, I
AF Venturini, Danielle
   Colado Simao, Andrea Name
   Urbano, Mariana Ragassi
   Dichi, Isaias
TI Effects of extra virgin olive oil and fish oil on lipid profile and
   oxidative stress in patients with metabolic syndrome
SO NUTRITION
LA English
DT Article
DE Metabolic syndrome; Olive oil; Fish oil; Lipid profile; Oxidative stress
ID N-3 FATTY-ACIDS; TOTAL ANTIOXIDANT CAPACITY; DISEASE RISK-FACTORS;
   MEDITERRANEAN DIET; CARDIOVASCULAR-DISEASE; PRIMARY PREVENTION; PROTEIN
   PRODUCTS; BLOOD-PRESSURE; SERUM-LIPIDS; URIC-ACID
AB Objective: The aim of this study was to verify if extra virgin olive oil and fish oil have a synergistic effect on lipid and oxidative stress parameters in patients with metabolic syndrome (MetS).
   Methods: This intervention study included 102 patients (81 women and 21 men) with MetS (mean age 51.45 +/- 8.27 y) from the ambulatory center of the University Hospital of Londrina, Parana, Brazil. Patients were randomly assigned to one of four groups: Patients in the control group (CG) were instructed to maintain their usual diet; the second group (fish oil group [FO]) received 3 g/d of fish oil omega-3 fatty acids (10 capsules); the third group (extra virgin olive oil group [00]) received 10 mL/d of extra virgin olive oil at lunch and dinner; and the fourth group (fish oil and extra virgin olive oil group [FOO]) received 3 g/d of fish oil omega-3 fatty acids and 10 mL/d of extra virgin olive oil. MetS related markers and oxidative stress were measured at baseline and after 90 d.
   Results: Differences across treatment groups showed a statistically significant decrease (P < 0.05) in total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) when FOO was compared with CG and OO, respectively. Hydroperoxides showed a significant decrease (P < 0.05) when FOO was compared with CG, whereas there was an increase in total peroxyl radical-trapping antioxidant potential/advanced oxidation protein products (TRAP/AOPP; P < 0.05) in FOO when compared with FO. In relation to baseline values, there was a significant decrease (P < 0.05) in LDL-C values, and TC/high-density lipoprotein cholesterol (HDL-C) and LDL-C/HDL-C indexes in FOO. There was also a decrease (P < 0.05) in hydroperoxides, in AOPP and in AOPP/TRAP index in FOO, and an increase (P < 0.05) in TRAP/AOPP index in FOO and in TRAP/uric acid ratio in OO.
   Conclusion: The present study provides evidence that increased dietary omega-3 polyunsaturated fatty acids and extra virgin olive oil have beneficial synergistic effects on lipid metabolism and oxidative stress in patients with MetS. (C) 2015 Elsevier Inc. All rights reserved.
C1 [Venturini, Danielle; Colado Simao, Andrea Name] Univ Londrina, Dept Pathol Clin Anal & Toxicol, Londrina, Parana, Brazil.
   [Urbano, Mariana Ragassi] Univ Londrina, Dept Stat, Londrina, Parana, Brazil.
   [Dichi, Isaias] Univ Londrina, Dept Internal Med, Londrina, Parana, Brazil.
RP Venturini, D (corresponding author), Univ Londrina, Dept Pathol Clin Anal & Toxicol, Londrina, Parana, Brazil.
EM Dichi@sercomtel.com.br
RI Venturini, Danielle/HPH-1330-2023; Urbano, Mariana/AAQ-5622-2021; Simão,
   Andrea/AAM-4892-2021
OI Urbano, Mariana/0000-0002-5411-5554
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NR 56
TC 75
Z9 81
U1 0
U2 34
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0899-9007
EI 1873-1244
J9 NUTRITION
JI Nutrition
PD JUN
PY 2015
VL 31
IS 6
BP 834
EP 840
DI 10.1016/j.nut.2014.12.016
PG 7
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA CH9GB
UT WOS:000354342900009
PM 25933490
DA 2025-06-11
ER

PT J
AU Vita, A
   Barlati, S
   Cavallaro, R
   Mucci, A
   Riva, MA
   Rocca, P
   Rossi, A
   Galderisi, S
AF Vita, Antonio
   Barlati, Stefano
   Cavallaro, Roberto
   Mucci, Armida
   Riva, Marco A.
   Rocca, Paola
   Rossi, Alessandro
   Galderisi, Silvana
TI Definition, assessment and treatment of cognitive impairment associated
   with schizophrenia: expert opinion and practical recommendations
SO FRONTIERS IN PSYCHIATRY
LA English
DT Review
DE CIAS; cognitive impairment; cognitive remediation; evidence-based;
   psychosocial functioning; psychosocial rehabilitation; schizophrenia;
   social cognition
ID DIRECT-CURRENT STIMULATION; SOCIAL COGNITION; METABOLIC SYNDROME;
   SPECTRUM DISORDERS; NEGATIVE SYMPTOMS; DOUBLE-BLIND; LONG-TERM;
   FOLLOW-UP; ANTICHOLINERGIC BURDEN; SUBSTANCE USE
AB A considerable proportion of patients with schizophrenia perform below population norms on standardized neuropsychological tests, and the performance of those performing within normal range is lower than predicted based on parental education. Cognitive impairment predates the onset of psychosis, is observed during symptom remission and in non-affected first-degree relatives of patients. At the present time, cognitive deficits are regarded as key features of schizophrenia, important determinants of poor psychosocial outcome and targets for both pharmacological and non-pharmacological treatment strategies. A group of eight key opinion leaders reviewed and discussed latest advances in scientific research and current good clinical practices on assessment, management, and treatment of CIAS. In the present paper they summarize the current evidence, identify main gaps between current knowledge and mental health services clinical practice, and provide practical recommendations to reduce the gap.
C1 [Vita, Antonio; Barlati, Stefano] Univ Brescia, Dept Clin & Expt Sci, Brescia, Italy.
   [Vita, Antonio; Barlati, Stefano] Azienda Socio Sanit Territoriale ASST Spedali Civi, Dept Mental Hlth & Addict Serv, Brescia, Italy.
   [Cavallaro, Roberto] Ist Sci San Raffaele, Sci Inst Res Hospitalizat & Healthcare IRCCS, Dept Clin Neurosci, Milan, Italy.
   [Cavallaro, Roberto] Univ Vita Salute San Raffaele, Sch Med, Milan, Italy.
   [Mucci, Armida; Galderisi, Silvana] Univ Campania Luigi Vanvitelli, Dept Mental & Phys Hlth & Prevent Med, Naples, Italy.
   [Riva, Marco A.] Univ Milan, Dept Pharmacol & Biomol Sci, Milan, Italy.
   [Riva, Marco A.] Sci Inst Res Hospitalizat & Healthcare IRCCS, Ist Ctr San Giovanni Dio Fatebenefratelli, Biol Psychiat Unit, Brescia, Italy.
   [Rocca, Paola] Univ Turin, Dept Neurosci Rita Levi Montalcini, Turin, Italy.
   [Rossi, Alessandro] Univ Aquila, Dept Biotechnol & Appl Clin Sci, Sect Psychiat, Laquila, Italy.
C3 University of Brescia; Vita-Salute San Raffaele University; IRCCS
   Ospedale San Raffaele; Vita-Salute San Raffaele University; Universita
   della Campania Vanvitelli; University of Milan; IRCCS Fatebenefratelli;
   University of Turin; University of L'Aquila
RP Barlati, S (corresponding author), Univ Brescia, Dept Clin & Expt Sci, Brescia, Italy.; Barlati, S (corresponding author), Azienda Socio Sanit Territoriale ASST Spedali Civi, Dept Mental Hlth & Addict Serv, Brescia, Italy.
EM stefano.barlati@unibs.it
RI Barlati, Stefano/M-2992-2017; Rocca, Paola/IIS-9400-2023; Vita,
   Antonio/K-4345-2018; Mucci, Armida/JDM-7796-2023; Riva, Marco
   Andrea/JAC-8536-2023
OI Vita, Antonio/0000-0002-3621-6394
FU Angelini Pharma
FX The author(s) declare that financial support was received for the
   research, authorship, and/or publication of this article. The authors
   declare that this study received funding from Angelini Pharma. The
   funder was not involved in the study design, collection, analysis,
   interpretation of data, the writing of this article, or the decision to
   submit it for publication.r The author(s) declare that financial support
   was received for the research, authorship, and/or publication of this
   article. The authors declare that this study received funding from
   Angelini Pharma. The funder was not involved in the study design,
   collection, analysis, interpretation of data, the writing of this
   article, or the decision to submit it for publication.
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NR 234
TC 3
Z9 3
U1 3
U2 5
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-0640
J9 FRONT PSYCHIATRY
JI Front. Psychiatry
PD SEP 20
PY 2024
VL 15
AR 1451832
DI 10.3389/fpsyt.2024.1451832
PG 14
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA H8L2Z
UT WOS:001325894100001
PM 39371908
OA gold
DA 2025-06-11
ER

PT J
AU Black, DR
   Held, ML
AF Black, Denise R.
   Held, Mary L.
TI Cardiovascular risk screening for individuals with serious mental
   illness
SO SOCIAL WORK IN HEALTH CARE
LA English
DT Article
DE Cardiovascular disease; screening; serious mental illness
ID METABOLIC SYNDROME; MEDICAL-CARE; HEALTH-CARE; SCHIZOPHRENIA; PEOPLE;
   DISORDERS; SMOKING; OBESITY; ACCESS; ADULTS
AB Cardiovascular disease (CVD) is a significant health risk for individuals with serious mental illness (SMI). Screening for CVD risk factors is a key strategy to reduce this health disparity. This study examined medical, lifestyle, and access predictors for comprehensive screening. Data on 1036 adults were analyzed from the 2015 National Health Interview Survey. Multivariate multinomial logistic regression was used to examine factors associated with individuals with SMI receiving CVD risk screening in the past 12months. The presence of a metabolic disorder (diabetes or high cholesterol), increased age, increased outpatient visits, and seeing a primary care provider, either alone or in conjunction with a specialty care provider, were significantly associated with receiving all screening measures. Increasing provider awareness of additional CVD risk factors is an essential step to improving early detection of health risks for individuals with SMI. Integrated health settings that combine traditional primary care and mental health services may reduce the health disparity for this population by increasing odds of early detection and ongoing monitoring for high-risk populations.
C1 [Black, Denise R.] Univ Tennessee, Coll Social Work, 1618 Cumberland Ave, Knoxville, TN 37996 USA.
   [Held, Mary L.] Univ Tennessee, Coll Social Work, Nashville, TN USA.
C3 University of Tennessee System; University of Tennessee Knoxville;
   University of Tennessee System; University of Tennessee Knoxville
RP Black, DR (corresponding author), Univ Tennessee, Coll Social Work, 1618 Cumberland Ave, Knoxville, TN 37996 USA.
EM dblack16@vols.utk.edu
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NR 43
TC 4
Z9 4
U1 1
U2 4
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 0098-1389
EI 1541-034X
J9 SOC WORK HEALTH CARE
JI Soc. Work Health Care
PY 2017
VL 56
IS 9
BP 809
EP 821
DI 10.1080/00981389.2017.1354955
PG 13
WC Social Work
WE Social Science Citation Index (SSCI)
SC Social Work
GA FE0ZA
UT WOS:000407947000003
PM 28771089
DA 2025-06-11
ER

PT J
AU Bobrowski, AE
AF Bobrowski, Amy E.
TI School and sports participation post-transplant
SO PEDIATRIC TRANSPLANTATION
LA English
DT Article
DE cognitive effects; physical activity; psychosocial effects; school
ID QUALITY-OF-LIFE; SOLID-ORGAN TRANSPLANTATION; PEDIATRIC HEART; METABOLIC
   SYNDROME; CARDIOVASCULAR-DISEASE; PHYSICAL-ACTIVITY;
   KIDNEY-TRANSPLANTATION; SCIENTIFIC STATEMENT; YOUNG-ADULTS; CHILDREN
AB Pediatric recipients of life-saving organ transplants are living longer, with improved graft and overall survivals. After successful transplant, children are encouraged to return to "normal life," with school attendance and participation in age-appropriate physical activities. This transition may cause stress to the recipients, parents, teachers, and other participating caregivers and staff. Planning for school reentry and assuring education for and open lines of communication with the school staff can help alleviate some of this discomfort and ease the process for the patient and the family. Cardiovascular disease has emerged as the leading cause of death in survivors of pediatric transplantation and is contributed to by modifiable risk factors such as obesity, hypertension, and the MS. Physical activity is a proven tool in decreasing surrogate markers of this risk. Sports participation is an important way to promote an enjoyment of physical activity that can ideally persist into adulthood, but conflicting advice and opinions exist regarding type and participation in physical activity. Moreover, specific recommendations are likely not applicable to all recipients, as certain degrees of rehabilitation may be needed depending on degree and length of illness. In general, a program of rehabilitation and increased physical activity has been shown to be safe and effective for most pediatric transplant recipients. Focusing on optimizing the "normal" childhood activities of going to school and participating in sports can improve the physical, social, cognitive, and mental health outcomes of this population after transplant and should be prioritized.
C1 [Bobrowski, Amy E.] Northwestern Univ, Ann & Robert H Lurie Childrens Hosp Chicago, Feinberg Sch Med, Div Pediat Kidney Dis, Chicago, IL 60611 USA.
C3 Ann & Robert H. Lurie Children's Hospital of Chicago; Northwestern
   University; Feinberg School of Medicine
RP Bobrowski, AE (corresponding author), Northwestern Univ, Ann & Robert H Lurie Childrens Hosp Chicago, Feinberg Sch Med, Div Pediat Kidney Dis, Chicago, IL 60611 USA.
EM abobrowski@luriechildrens.org
OI Bobrowski, Amy/0000-0002-1924-0659
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NR 65
TC 5
Z9 5
U1 1
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1397-3142
EI 1399-3046
J9 PEDIATR TRANSPLANT
JI Pediatr. Transplant.
PD FEB
PY 2021
VL 25
IS 1
AR e13791
DI 10.1111/petr.13791
EA JUL 2020
PG 8
WC Pediatrics; Transplantation
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Pediatrics; Transplantation
GA YY1FO
UT WOS:000552878200001
PM 33202076
DA 2025-06-11
ER

PT J
AU Ferraz-Bannitz, R
   Beraldo, RA
   Coelho, PO
   Moreira, AC
   Castro, M
   Foss-Freitas, MC
AF Ferraz-Bannitz, Rafael
   Beraldo, Rebeca A.
   Coelho, Priscila Oliveira
   Moreira, Ayrton C.
   Castro, Margaret
   Foss-Freitas, Maria Cristina
TI Circadian Misalignment Induced by Chronic Night Shift Work Promotes
   Endoplasmic Reticulum Stress Activation Impacting Directly on Human
   Metabolism
SO BIOLOGY-BASEL
LA English
DT Article
DE endoplasmic reticulum stress; CLOCK genes; night shift; circadian
   rhythm; metabolic syndrome
AB Simple Summary
   The demands of modern society have made shift work a necessity. Night work is associated with an increased risk of metabolic problems such as obesity and diabetes, which is mainly due to the misalignment of circadian rhythms that play a crucial role in many biological processes. This study performed clinical, anthropometric, and molecular analyses on 40 hospital workers who work day or night. We demonstrated that night workers had increased glucose levels, triglycerides, waist circumference, and blood pressure compared to day workers. Surprisingly, we report that night workers have significant changes in the expression of circadian clock genes and an up-regulation of genes related to endoplasmic reticulum stress (ERS). These findings provide new insights into the effects of night shift work on the expression of circadian cycle genes and ERS activation, leading to metabolic stress and the development of metabolic diseases associated with night work.
   Night work has become necessary in our modern society. However, sleep deprivation induces a circadian misalignment that effectively contributes to the development of diseases associated with metabolic syndrome, such as obesity and diabetes. Here, we evaluated the pattern of circadian clock genes and endoplasmic reticulum stress (ERS) genes in addition to metabolic and anthropometric measures in subjects that work during a nocturnal period compared with day workers. We study 20 night workers (NW) and 20 day workers (DW) submitted to a work schedule of 12 h of work for 36 h of rest for at least 5 years in a hospital. The present report shows that NW have increased fasting blood glucose, glycated hemoglobin (HbA1c), triglycerides, and low-density lipoprotein (LDL)-cholesterol levels, and lower high-density lipoprotein (HDL)-cholesterol levels compared to DW. In addition, we observed that waist circumference (WC), waist-hip ratio (WHR), and systemic blood pressure are also increased in NW. Interestingly, gene expression analysis showed changes in CLOCK gene expression in peripheral blood mononuclear cells (PBMC) samples of NW compared to the DW, evidencing a peripheral circadian misalignment. This metabolic adaptation was accompanied by the up-regulation of many genes of ERS in NW. These findings support the hypothesis that night shift work results in disturbed glycemic and lipid control and affects the circadian cycle through the deregulation of peripheral CLOCK genes, which is possibly due to the activation of ERS. Thus, night work induces important metabolic changes that increase the risk of developing metabolic syndrome.
C1 [Ferraz-Bannitz, Rafael; Beraldo, Rebeca A.; Moreira, Ayrton C.; Castro, Margaret; Foss-Freitas, Maria Cristina] Ribeirao Preto Med Sch, Dept Internal Med, Div Endocrinol & Metab, Ave Bandeirantes,3900 Vila Monte Alegre, BR-14049900 Ribeirao Preto, SP, Brazil.
   [Coelho, Priscila Oliveira] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Biochem, Ave Bandeirantes,3900 Vila Monte Alegre, BR-14049900 Ribeirao Preto, SP, Brazil.
C3 Universidade de Sao Paulo
RP Ferraz-Bannitz, R (corresponding author), Ribeirao Preto Med Sch, Dept Internal Med, Div Endocrinol & Metab, Ave Bandeirantes,3900 Vila Monte Alegre, BR-14049900 Ribeirao Preto, SP, Brazil.
EM ferrazrafael@usp.br; rebecaberaldo@yahoo.com.br;
   priscila_coelho6@hotmail.com; acmoreir@fmrp.usp.br; castrom@fmrp.usp.br;
   crisfoss@fmrp.usp.br
RI Foss-Freitas, Maria/AAV-5971-2021; Ferraz-Bannitz, Rafael/AAI-2715-2021;
   Beraldo, Rebeca/J-7380-2016; Coelho, Priscila/JCE-1771-2023;
   Foss-Freitas, Maria Cristina/F-1197-2013; de Castro,
   Margaret/A-4918-2009; Ferraz-Bannitz, Rafael/C-2390-2018
OI Foss-Freitas, Maria Cristina/0000-0002-1350-1125; de Castro,
   Margaret/0000-0003-4932-4623; Ferraz-Bannitz, Rafael/0000-0003-4496-4883
FU Fundacao de Apoio ao Ensino Pesquisa e Assistencia (FAEPA); Fundacao de
   Amparo a Pesquisa do Estado de Sao Paulo-FAPESP [2015/12133-0]
FX This work was supported by Fundacao de Apoio ao Ensino Pesquisa e
   Assistencia (FAEPA) and the Fundacao de Amparo a Pesquisa do Estado de
   Sao Paulo-FAPESP (2015/12133-0).
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NR 55
TC 13
Z9 16
U1 3
U2 8
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2079-7737
J9 BIOLOGY-BASEL
JI Biology-Basel
PD MAR
PY 2021
VL 10
IS 3
AR 197
DI 10.3390/biology10030197
PG 13
WC Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics
GA RD3CT
UT WOS:000633361300001
PM 33807589
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Ma, S
   Mifflin, SW
   Cunningham, JT
   Morilak, DA
AF Ma, S.
   Mifflin, S. W.
   Cunningham, J. T.
   Morilak, D. A.
TI Chronic intermittent hypoxia sensitizes acute
   hypothalamic-pituitary-adrenal stress reactivity and Fos induction in
   the rat locus coeruleus in response to subsequent immobilization stress
SO NEUROSCIENCE
LA English
DT Article
DE adrenocorticotropic hormone; metabolic syndrome; norepinephrine;
   obstructive sleep apnea; paraventricular nucleus; stress
ID OBSTRUCTIVE SLEEP-APNEA; EARLY GENE-EXPRESSION; PARAVENTRICULAR NUCLEUS;
   CELL RESPONSES; BRAIN-STEM; CORTICOSTERONE RESPONSES; NOREPINEPHRINE
   RELEASE; SUPRAOPTIC NUCLEI; MEDIAL AMYGDALA; BED NUCLEUS
AB Obstructive sleep apnea (OSA) is associated with several pathophysiological conditions, including hypertension, obesity, insulin resistance, hypothalamic-pituitary-adrenal (HPA) dysregulation, and other endocrine and metabolic disturbances comprising the "metabolic syndrome." Repeated episodes of hypoxia in OSA may represent a chronic intermittent stress, leading to HPA dysregulation. Alterations in HPA reactivity could then contribute to or exacerbate other pathophysiological processes. We showed previously that another metabolic stressor, chronic intermittent cold stress, enhanced noradrenergic facilitation of acute HPA stress reactivity. In this study, we investigated whether chronic intermittent hypoxia (CIH), a rat model for the arterial hypoxemia that accompanies OSA, similarly sensitizes the HPA response to novel acute stress. Rats were exposed to CIH (alternating cycles of normoxia [3 min at 21% O-2] and hypoxia [3 min at 10% O-2], repeated continuously for 8 h/day during the light portion of the cycle for 7 days). On the day after the final CIH exposure, there were no differences in baseline plasma adrenocorticotropic hormone (ACTH), but the peak ACTH response to 30 min acute immobilization stress was greater in CIH-stressed rats than in controls. Induction of Fos expression by acute immobilization stress was comparable following CIH in several HPA-modulatory brain regions, including the paraventricular nucleus, bed nucleus of the stria terminalis, and amygdala. Fos induction was attenuated in lateral hypothalamus, an HPA-inhibitory region. By contrast, acute Fos induction was enhanced in noradrenergic neurons in the locus coeruleus following CIH exposure. Thus, similar to chronic cold stress, CIH sensitized acute HPA and noradrenergic stress reactivity. Plasticity in the acute stress response is important for long-term adaptation, but may also contribute to pathophysiological conditions associated with states of chronic or repeated stress, such as OSA. Determining the neural mechanisms underlying these adaptations may help us better understand the etiology of such disorders, and inform the development of more effective treatments. (C) 2008 IBRO. Published by Elsevier Ltd. All rights reserved.
C1 Univ Texas Hlth Sci Ctr San Antonio, Dept Pharmacol, San Antonio, TX 78229 USA.
   Univ Texas Hlth Sci Ctr San Antonio, Ctr Biomed Neurosci, San Antonio, TX 78229 USA.
C3 University of Texas System; University of Texas Health Science Center at
   San Antonio; University of Texas System; University of Texas Health
   Science Center at San Antonio
RP Morilak, DA (corresponding author), Univ Texas Hlth Sci Ctr San Antonio, Dept Pharmacol, MC 7764,7703 Floyd Curl Dr, San Antonio, TX 78229 USA.
EM morilak@uthscsa.edu
RI Morilak, David/Q-4986-2019
OI Cunningham, J. Thomas/0000-0001-8859-9481
FU NHLBI NIH HHS [R56 HL062579, HL062579, R01 HL062579, R01 HL086804,
   HL086804, P01 HL088052] Funding Source: Medline; NIMH NIH HHS [R01
   MH053851, MH053851, R01 MH072672, R29 MH053851, R56 MH053851, MH072672]
   Funding Source: Medline
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NR 75
TC 69
Z9 84
U1 0
U2 6
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4522
EI 1873-7544
J9 NEUROSCIENCE
JI Neuroscience
PD JUL 17
PY 2008
VL 154
IS 4
BP 1639
EP 1647
DI 10.1016/j.neuroscience.2008.04.068
PG 9
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 326RZ
UT WOS:000257677900047
PM 18554809
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Guo, QW
   Si, YJ
   Shen, YL
   Chen, X
   Yang, M
   Fang, DZ
   Lin, J
AF Guo, Qi Wei
   Si, Yan Jun
   Shen, Yi Lin
   Chen, Xu
   Yang, Mei
   Fang, Ding Zhi
   Lin, Jia
TI Depression Augments Plasma APOA4 without Changes of Plasma Lipids and
   Glucose in Female Adolescents Carrying G Allele of APOA4 rs5104
SO JOURNAL OF MOLECULAR NEUROSCIENCE
LA English
DT Article
DE Apolipoprotein A4; Depression; Single nucleotide polymorphism; Lipids;
   Glucose
ID APOLIPOPROTEIN-A-IV; LOW-DENSITY-LIPOPROTEIN; HDL-CHOLESTEROL LEVELS;
   GENE-CLUSTER; METABOLIC SYNDROME; SERUM; RISK; POLYMORPHISMS;
   BIOMARKERS; DISORDER
AB The association of apolipoprotein AIV (APOA4) with depression or plasma levels of lipids and glucose has been inconsistently reported. However, interplays between APOA4 and depression on the levels have not been explored yet. The present study aimed to investigate plasma levels of APOA4, lipids, and glucose in adolescents with different genotypes of APOA4 rs5104 and with or without depression. Depressive symptoms were assessed in 631 adolescents by Beck Depression Inventory (BDI). A total score of 14 was defined as the cutoff point for depression. Plasma levels of triglycerides (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), glucose, and insulin were measured by routine methods, and APOA4 by enzyme-linked immunosorbent assays. Genotyping was performed by polymerase chain reaction-restriction fragment length polymorphism analyses and verified by DNA sequencing. Female adolescents had higher prevalence of depression than male subjects only in G allele carriers (p = 0.015), but not in AA homozygotes. Risk factors of depression and predictors of depression severity were different between G allele carriers and AA homozygotes. Lower levels of glucose (p = 0.003) were observed in male G allele carriers than those in male AA homozygotes and increased TG levels (p = 0.008) in female G allele carriers when compared with those in female AA homozygotes. When both APOA4 rs5104 and depression were taken into account, subjects with depression had higher levels of plasma APOA4 than adolescents without depression only in female G allele carriers (p = 0.043), but no significant changes of plasma lipids and glucose. Depression augments plasma APOA4 levels without changes of plasma lipids and glucose in female adolescents carrying G allele of APOA4 rs5104. These results may provide a novel explanation for the inconsistent relationship between depression, APOA4, and plasma levels of lipids and glucose in the literature.
C1 [Guo, Qi Wei; Si, Yan Jun; Shen, Yi Lin; Chen, Xu; Yang, Mei; Fang, Ding Zhi; Lin, Jia] Sichuan Univ, West China Sch Basic Med Sci & Forens Med, Dept Biochem & Mol Biol, Chengdu, Peoples R China.
C3 Sichuan University
RP Lin, J (corresponding author), Sichuan Univ, West China Sch Basic Med Sci & Forens Med, Dept Biochem & Mol Biol, Chengdu, Peoples R China.
EM jialin@scu.edu.cn
RI Shen, Yilin/AAG-1724-2020; 斯, 艳君/HIR-1437-2022
OI Lin, Jia/0000-0001-6497-4267
FU National Natural Science Foundation of China [81974043]
FX This work was supported by the National Natural Science Foundation of
   China (Grant No. 81974043). Professor Ding Zhi Fang is the recipient of
   the grant.
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NR 51
TC 5
Z9 5
U1 2
U2 18
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0895-8696
EI 1559-1166
J9 J MOL NEUROSCI
JI J. Mol. Neurosci.
PD OCT
PY 2021
VL 71
IS 10
BP 2060
EP 2070
DI 10.1007/s12031-020-01766-7
EA JAN 2021
PG 11
WC Biochemistry & Molecular Biology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Biochemistry & Molecular Biology; Neurosciences & Neurology
GA WD9IN
UT WOS:000605137900002
PM 33403595
DA 2025-06-11
ER

PT J
AU Romeo, J
   Wärnberg, J
   Gómez-Martínez, S
   Díaz, LE
   Marcos, A
AF Romeo, Javier
   Warnberg, Julia
   Gomez-Martinez, Sonia
   Esperanza Diaz, Ligia
   Marcos, Ascension
TI Neuroimmunomodulation by Nutrition in Stress Situations
SO NEUROIMMUNOMODULATION
LA English
DT Article
DE Nutrition; Stress; Immune system; Neuroendocrine system
ID PITUITARY-ADRENAL-AXIS; METABOLIC SYNDROME; DIETARY RESTRAINT;
   RESPONSES; CORTISOL; IMMUNITY; HORMONES; OBESITY; WOMEN; HUMANS
AB Stress has long been suspected to play a role in the etiology of many diseases and may be detrimental to health. Nowadays, the communication between the neuroendocrine and the immune systems is well established and there is enough evidence that the magnitude of stress-associated immune dysregulation is large enough to have health implications. In stress conditions, modulation of the immune system by the central nervous system (CNS) is mediated by a complex network of signals, showing a relationship between stress and resistance to infection. On the other hand, an adequate balanced diet plays a crucial role in the management of stress, and nutrition seems to be a critical determinant in the interactions among CNS and the immune system under stress conditions. Thus, interactions among nutrition, CNS and the immune system could be a key to understand implications in physiological stress situations. The present article will briefly review nutrition approaches on stress-related immune response and CNS communication. Copyright (c) 2008 S. Karger AG, Basel
C1 [Romeo, Javier; Warnberg, Julia; Gomez-Martinez, Sonia; Esperanza Diaz, Ligia; Marcos, Ascension] Sci Natl Res Council CSIC, ICTAN, Inst Frio, Immunonutr Res Grp,Dept Metab & Nutr, Madrid, Spain.
C3 Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Instituto
   de Ciencia y Tecnologia de Alimentos y Nutricion (ICTAN)
RP Romeo, J (corresponding author), CSIC, Inst Frio, Grp Inmunonutr, Dept Metab & Nutr, Calle Jose Antonio Novais 10, ES-28040 Madrid, Spain.
EM jromeo@if.csic.es
RI Sanchez, Ascension/K-4965-2014; Gómez Martínez, Sonia/Q-2626-2017;
   Warnberg, Julia/G-1390-2011
OI Warnberg, Julia/0000-0002-8408-316X
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NR 44
TC 7
Z9 7
U1 1
U2 19
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1021-7401
EI 1423-0216
J9 NEUROIMMUNOMODULAT
JI Neuroimmunomodulation
PY 2008
VL 15
IS 3
BP 165
EP 169
DI 10.1159/000153420
PG 5
WC Endocrinology & Metabolism; Immunology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Immunology; Neurosciences & Neurology
GA 358BX
UT WOS:000259892600004
PM 18781080
DA 2025-06-11
ER

PT J
AU Piegza, M
   Badura-Brzoza, K
   Pudlo, R
   Piegza, J
   Kunert, L
   Jaworska, I
   Sobis, J
   Blachut, M
   Gorczyca, PW
AF Piegza, Magdalena
   Badura-Brzoza, Karina
   Pudlo, Robert
   Piegza, Jacek
   Kunert, Lukasz
   Jaworska, Izabela
   Sobis, Jaroslaw
   Blachut, Michal
   Gorczyca, Piotr W.
TI The sense of coherence in women undergoing coronary arteriography
SO PSYCHIATRIA POLSKA
LA English
DT Article
DE coronary artery disease; sense of coherence; cardiac syndrome X
ID QUALITY-OF-LIFE; HEART-DISEASE; HEALTH; POPULATION; PREDICTOR
AB Aim. The examination referred to two groups of female patients: with and without significant coronary stenoses in coronarography. There were two stages of the examination: before and 6-9 months after coronarography. The factor dividing patients into two groups: without significant atheromatosis and with coronary atheromatosis, was the result of invasive diagnostics of coronary heart disease.
   Methods. The sense of coherence scale (SOC-29) and sociodemographic questionnaires were used to evaluate the condition of the two groups.
   Results. In group of patients with irrelevant coronary stenoses statistically lower values of sense of comprehension were noticed in the first and the second examination and also statistically lower values of sense of manage were observed, comparing to the group of patients with significant stenoses. The initial value of general coherence was comparable in both groups and did not significantly change in 6-9 months after coronarography. The characteristic parameters: lack of social support, intensity of depressiveness and anxiety before getting information about necessity of coronarography and worse education were connected with lower sense of coherence.
   Conclusions. The baseline strength of the total sense of coherence was not different between groups. Patients with no significant stenosis of coronary arteries demonstrate a lower sense of comprehensibility before and after the coronary arteriography and lower sense of manageability after the procedure compared to the group of patients with significant atherosclerotic lesions. No social support, tendency for depression and anxiety and lower level of education
C1 [Piegza, Magdalena; Badura-Brzoza, Karina; Pudlo, Robert; Kunert, Lukasz; Sobis, Jaroslaw; Blachut, Michal; Gorczyca, Piotr W.] Med Univ Silesia, Dept & Clin Psychiat, Tarnowskie Gory, Poland.
   [Piegza, Jacek; Jaworska, Izabela] SCCS, Dept Cardiol 3, Zabrze, Poland.
C3 Medical University of Silesia
RP Kunert, L (corresponding author), Silesian Med Sch, Fac Med Zabrze, Chair & Dept Psychiat, Div Dent, Ul Pyskowicka 49, PL-42612 Tarnowskie Gory, Poland.
RI Pudlo, Robert/HKF-1660-2023
OI Pudlo, Robert/0000-0002-5748-0063; Blachut, Michal/0000-0002-4438-2376;
   Jaworska, Izabela/0000-0001-5090-2385
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NR 26
TC 4
Z9 5
U1 0
U2 9
PU WYDAWNICZY POLSKIEGO TOWARZYSTWA
PI CRACOW
PA LENARTOWICZA 14 STRREET,, CRACOW, 31-138, POLAND
SN 0033-2674
J9 PSYCHIATR POL
JI Psychiatr. Pol.
PY 2014
VL 48
IS 5
BP 975
EP 986
DI 10.12740/PP/24452
PG 12
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychiatry
GA AW9SD
UT WOS:000346596500008
PM 25639017
OA gold
DA 2025-06-11
ER

PT J
AU Fiedorowicz, JG
   Palagummi, NM
   Behrendtsen, O
   Coryell, WH
AF Fiedorowicz, Jess G.
   Palagummi, Narasimha M.
   Behrendtsen, Ole
   Coryell, William H.
TI Cholesterol and affective morbidity
SO PSYCHIATRY RESEARCH
LA English
DT Article
DE Cholesterol; Major depression; Bipolar disorder; Mania; Depression
ID MAJOR DEPRESSIVE DISORDER; RESEARCH DIAGNOSTIC CRITERIA; CARDIOVASCULAR
   RISK-FACTORS; SERUM-CHOLESTEROL; BIPOLAR-DISORDER; MEMBRANE CHOLESTEROL;
   PLASMA-CHOLESTEROL; SUICIDE ATTEMPTERS; METABOLIC SYNDROME; MOOD
   DISORDERS
AB Depression and mania have been linked with low cholesterol though there has been limited prospective study of cholesterol and subsequent course of affective illness. We studied the relationship between fasting total cholesterol and subsequent depressive and manic symptoms. A total of 131 participants from a prospective cohort study were identified as having had a fasting total cholesterol evaluation at intake. Participants were predominantly inpatients at index visit and were followed for a median of 20 and up to 25 years. Cholesterol was modeled with age, gender, and index use of a mood stabilizer in linear regression to assess its influence on subsequent depressive symptom burden in participants with unipolar disorder as well as depressive and manic symptom burden in participants with bipolar disorder. Among bipolar participants (N = 65), low cholesterol predicted a higher proportion of follow-up weeks with manic, but not depressive symptoms. Cholesterol did not appear to predict depressive symptom burden among participants with unipolar depression (N = 66). Lower cholesterol levels may predispose individuals with bipolar disorder to a greater burden of manic symptomatology and may provide some insight into the underlying neurobiology. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
C1 [Fiedorowicz, Jess G.; Behrendtsen, Ole; Coryell, William H.] Univ Iowa, Dept Psychiat, Roy J & Lucille A Carver Coll Med, Iowa City, IA 52242 USA.
   [Behrendtsen, Ole] Univ Iowa, Dept Internal Med, Roy J & Lucille A Carver Coll Med, Iowa City, IA 52242 USA.
   [Palagummi, Narasimha M.] Marshalltown Med Clin, Marshalltown, IA USA.
C3 University of Iowa; University of Iowa
RP Fiedorowicz, JG (corresponding author), 200 Hawkins Dr,W278GH, Iowa City, IA 52242 USA.
EM jess-fiedorowicz@uiowa.edu
RI Fiedorowicz, Jess/I-2512-2019
OI coryell, william/0000-0003-3989-7276; Fiedorowicz,
   Jess/0000-0003-2057-4071
FU NIMH [MH 25416]; Nellie Ball Trust Research Fund [L30 MH075180-02];
   NARSAD
FX This study was funded by NIMH grant MH 25416. Dr. Fiedorowicz is
   supported by L30 MH075180-02, the Nellie Ball Trust Research Fund, and a
   NARSAD Young Investigator Award. He has received research support for
   participating in a colleague's investigator-initiated study with Eli
   Lilly. The authors have no potential conflicts of interest, financial or
   otherwise. The authors thank Carol Moss and Barbara Robb for assistance
   with data management as well as Myra Fiedorowicz and Lois Warren for
   assistance with manuscript editing.
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NR 57
TC 18
Z9 19
U1 0
U2 1
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0165-1781
J9 PSYCHIAT RES
JI Psychiatry Res.
PD JAN
PY 2010
VL 175
IS 1-2
BP 78
EP 81
DI 10.1016/j.psychres.2009.01.001
PG 4
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 553NT
UT WOS:000274374800015
PM 19969372
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Aciksari, G
   Demir, B
   Uygun, T
   Gedikbasi, A
   Kutlu, O
   Atici, A
   Baycan, OF
   Kocak, M
   Kul, S
AF Aciksari, Gonul
   Demir, Bulent
   Uygun, Turgut
   Gedikbasi, Asuman
   Kutlu, Orkide
   Atici, Adem
   Baycan, Omer Faruk
   Kocak, Mehmet
   Kul, Seref
TI Serum prolidase activity in patients with cardiac syndrome X
SO NORTHERN CLINICS OF ISTANBUL
LA English
DT Article
DE Cardiac syndrome X; collagen; serum prolidase activity
ID CORONARY-ARTERY-DISEASE; ANGINA-PECTORIS; CHEST-PAIN;
   EXTRACELLULAR-MATRIX; OXIDATIVE STRESS; ASSOCIATION
AB OBJECTIVE: Although the underlying mechanism is not yet fully understood, Cardiac Syndrome X (CSX) is defined as microvascular dysfunction. Prolidase plays a role in collagen synthesis. Increased serum prolidase activity (SPA) has been shown to correlate with collagen turnover. Augmented collagen turn-over may be associated with vascular fibrosis and microvascular dysfunction. In this study, we assessed whether there was a correlation between CXS and prolidase activity.
   METHODS: This case-control study included 45 consecutive CSX patients (mean age 50.7 +/- 6.5 years, 27 women) and 40 healthy controls (mean age 51.2 +/- 6.5 years, 25 women). Prolidase activity was determined with the Human Xaa-Pro Dipeptidase/Prolidase enzyme-linked immunosorbent assay kit (Cusabio Biotech Co. Ltd, China).
   RESULTS: Mean prolidase activity was 898.8 +/- 639.1 mU/mL in the CSX group and 434.1 +/- 289.8 mU/mL in the control group (p<0.001). In ROC analysis, it was found that the SPA value above 350 mU/mL sympathizes with the diagnosis of CSX.
   CONCLUSION: Increased SPA in CXS patients may play an essential role in the pathophysiology of CSX, leading to augmented oxidative stress and vascular fibrosis, endothelial dysfunction, and increased microvascular resistance.
C1 [Aciksari, Gonul; Atici, Adem; Baycan, Omer Faruk; Kul, Seref] Istanbul Medeniyet Univ, Dept Cardiol, Gortepe Training & Res Hosp, Istanbul, Turkey.
   [Demir, Bulent] Bakirkoy Dr Sadi Konuk Training & Res Hosp, Dept Cardiol, Istanbul, Turkey.
   [Uygun, Turgut] Konya Training & Res Hosp, Dept Cardiol, Konya, Turkey.
   [Gedikbasi, Asuman] Bakirkoy Dr Sadi Konuk Training & Res Hosp, Dept Biochem, Istanbul, Turkey.
   [Kutlu, Orkide] Okmeydani Training & Res Hosp, Dept Internal Med, Istanbul, Turkey.
   [Kocak, Mehmet] Fatih Sultan Mehmet Training & Res Hosp, Dept Emergency Med, Istanbul, Turkey.
C3 Istanbul Medeniyet University; Bakirkoy Dr. Sadi Konuk Research &
   Training Hospital; Konya Egitim Training & Research Hospital; Bakirkoy
   Dr. Sadi Konuk Research & Training Hospital; Istanbul Okmeydani Training
   & Research Hospital; Fatih Sultan Mehmet Training & Research Hospital
RP Aciksari, G (corresponding author), Istanbul Medeniyet Univ, Dept Cardiol, Gortepe Training & Res Hosp, Istanbul, Turkey.
EM drgonulkutlu@hotmail.com
RI Baycan, Omer/GSI-6455-2022; Demir, Bulent/KVC-1688-2024; aciksari,
   gonul/LXW-1995-2024; Gedikbasi, Asuman/AAE-3613-2020; kul,
   seref/KSL-9750-2024; Kocak, Mehmet/AAE-2382-2019
OI Demir, Bulent/0000-0003-1767-408X; Kocak, Mehmet/0000-0003-0782-390X
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NR 39
TC 3
Z9 3
U1 0
U2 6
PU KARE PUBL
PI ISTANBUL
PA CONCORD ISTANBUL, DUMLUPINAR MAH, CIHAN SK NO 15, B BLOK 162 KADIKOY,
   ISTANBUL, 00000, TURKEY
SN 2148-4902
J9 NORTH CLIN ISTANB
JI North. Clin. Istanb.
PY 2020
VL 7
IS 5
BP 471
EP 477
DI 10.14744/nci.2020.09086
PG 7
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA OC8BS
UT WOS:000579382100009
PM 33163883
OA Green Published
DA 2025-06-11
ER

PT J
AU Chen, YC
   Hou, CJY
   Tsai, CH
   Yeh, HI
AF Chen, Yung-Chih
   Hou, Charles Jia-Yin
   Tsai, Cheng-Ho
   Yeh, Hung-I
TI RELATIONSHIPS OF THE THROMBOLYSIS IN MYOCARDIAL INFARCTION FRAME COUNT
   WITH CLINICAL, HEMODYNAMIC AND MEDICINE VARIABLES IN SYNDROME X PATIENTS
SO INTERNATIONAL JOURNAL OF GERONTOLOGY
LA English
DT Article
DE microvascular dysfunction; syndrome X; TIMI frame count
ID CORONARY FLOW RESERVE; CONVERTING ENZYME-INHIBITION; LEFT-VENTRICULAR
   FUNCTION; ANGINA-PECTORIS; CHEST-PAIN; ARTERIOGRAMS; RESISTANCE; IMPACT;
   HEART
AB Background: The thrombolysis in myocardial infarction (TIMI) frame count was reported to reflect coronary blood flow and have prognostic value. However, such data in syndrome X was lacking. The purpose of this study was to examine the prognostic value of the TIMI frame count in syndrome X patients, compared with the normal population.
   Methods: The TIMI frame count was measured in 2,049 consecutive patients referred for coronaryangiography from March 2003 to February 2005.
   Results: Among 308 patients with normal coronary angiograms, 44 undergoing the procedure for electrophysiologic studies or valvular heart disease surveys other than angina were designated normal controls. Another 155 patients with positive stress test results were diagnosed as syndrome X. Comparisons of the two groups showed that the syndrome X patients had higher frame counts in the left anterior descending artery (40.9 +/- 15.7 vs. 47.8 +/- 25.4; p < 0.05) and left circumflex artery (35.2 +/- 11.7 vs. 42.0 +/- 18.7; p<0.05). A similar trend was found in the right coronary artery (29.3 +/- 13.5 vs. 31.9 +/- 15.9; p = 0.2). The TIMI frame count in each artery of the syndrome X group was related to the patients' variables (sex, age, and body mass index), clinical variables (medication use, diabetes, hypertension, hypercholesterolemia, smoking, and family history), and hemodynamic variables (aortic systolic blood pressure and left ventricular end-diastolic pressure). By multivariate analysis, the TIMI frame counts in all arteries were significantly higher in women and lower with angiotensin-converting enzyme inhibitor (ACEI) use (both p<0.05). The frame count in the left anterior descending was associated with diuretics use (p<0.05).
   Conclusion: Our TIMI frame count data confirm the presence of slow coronary flow in syndrome X patients, especially women. ACEI use shortens the counts in these patients, suggesting that ACEIs have the potential to correct the underlying hemodynamic defects in such patients. [International Journal of Gerontology 2008-2(3): 109-114]
C1 [Hou, Charles Jia-Yin; Tsai, Cheng-Ho; Yeh, Hung-I] Mackay Mem Hosp, Taipei 10449, Taiwan.
   [Chen, Yung-Chih] Taitung Mackay Mem Hosp, Dept Internal Med, Div Cardiovasc, Taipei, Taiwan.
   [Tsai, Cheng-Ho; Yeh, Hung-I] Taipei Med Univ, Mackay Med Nursing & Management Coll, Taipei, Taiwan.
C3 Mackay Memorial Hospital; Mackay Memorial Hospital; Taipei Medical
   University; Mackay Junior College of Medicine, Nursing & Management
RP Yeh, HI (corresponding author), Mackay Mem Hosp, 92,Sect 2 Chung San N Rd, Taipei 10449, Taiwan.
EM hiyeh@ms1.mmh.org.tw
FU Medical Research Department of the Mackay Memorial Hospital, Taiwan
   [MMH-9257, 94E-003]
FX This work was supported by grants MMH-9257 and 94E-003 from the Medical
   Research Department of the Mackay Memorial Hospital, Taiwan. The authors
   thank colleagues in the Cardiovascular Division for assistance in
   recruiting the study participants. The data collection by Hsin-Yu Chlu
   is appreciated.
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NR 27
TC 1
Z9 1
U1 0
U2 1
PU TAIWAN SOC GERIATRIC EMERGENCY & CRITICAL CARE MEDICINE-TSGECM
PI TAIPEI
PA 12F-14, NO 42, SEC 1, MINSHENG E RD, ZHONGSHAN DIST, TAIPEI, 104, TAIWAN
SN 1873-9598
EI 1873-958X
J9 INT J GERONTOL
JI Int. J. Gerontol.
PD SEP
PY 2008
VL 2
IS 3
BP 109
EP 114
DI 10.1016/S1873-9598(08)70047-4
PG 6
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA 371PQ
UT WOS:000260843800005
DA 2025-06-11
ER

PT J
AU Averyanova, IV
AF Averyanova, I. V.
TI Association of 25(OH) Vitamin D with Cardiometabolic Risk Factors in the
   Age Aspect
SO BIOCHEMISTRY MOSCOW-SUPPLEMENT SERIES B-BIOMEDICAL CHEMISTRY
LA English
DT Article
DE young men; mature men; elderly men; cardiometabolic risk factors;
   vitamin D
ID HOMEOSTASIS MODEL ASSESSMENT; SERUM 25-HYDROXYVITAMIN D;
   INSULIN-RESISTANCE; D DEFICIENCY; PARATHYROID-HORMONE; GLUCOSE
AB Background: This study assessed the association of vitamin D status with the frequency of incidence of metabolic health risk factors, including obesity, hypo-alpha cholesterol, hypertriglyceridemia, carbohydrate metabolism disorders (hyperglycemia and insulin resistance), and cardiovascular system stress conditions in men of different ages. Aim: The research aimed at identifying cardiometabolic disorders in young, mature, and elderly men with suboptimal and optimal concentrations of 25(OH) vitamin D. Materials and methods: Two hundred and thirty-four Magadan oblast residents at early adulthood, maturity, and extreme old age participated in the survey. Each age group was divided into two samples: with optimal or suboptimal vitamin D level. We used photometric, immunochemiluminescent research methods, as well as standard methods for assessing body mass index and cardiovascular system. Results: The results showed rather high incidence of suboptimal 25(OH) vitamin D levels among the Magadan oblast population. Optimal vitamin D concentration was associated with a significant fall in the percentage of people with a hypertensive character of cardiovascular performance, with a lower incidence of hypoalphacholesterolemia, hyperglycemia, hypertriglyceridemia, and insulin resistance throughout all age groups, and was more common in elderly men. Conclusions: The suboptimal concentration of vitamin D can be considered as an additional nonstandard driving factor for age-associated cardiometabolic disorders. Metabolic healthcare needs preventive measures to level these disorders to contribute to active longevity and life expectancy.
C1 [Averyanova, I. V.] Russian Acad Sci, Arctic Sci Res Ctr, Far East Branch, Magadan 685000, Russia.
C3 Russian Academy of Sciences
RP Averyanova, IV (corresponding author), Russian Acad Sci, Arctic Sci Res Ctr, Far East Branch, Magadan 685000, Russia.
EM Inessa1382@mail.ru
RI Inessa, Averyanova/AAR-9371-2020
FU Arctic Scientific Research Center, Far East Branch, Russian Academy of
   Sciences [AAAA-A21-121010 69 0002-2]
FX The work was carried out with budget funding from the Arctic Scientific
   Research Center, Far East Branch, Russian Academy of Sciences within the
   framework of the topic Study of Intersystem and Intrasystem Reaction
   Mechanisms in the Formation of Functional Adaptive Reserves of the Human
   Body of the "Northern Type" at Different Stages of Ontogenesis of
   Persons Living in Uncomfortable and Extreme Conditions with the
   Determination of Integral Informative Health Indices (registration no.
   AAAA-A21-121010 69 0002-2).
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NR 41
TC 0
Z9 0
U1 0
U2 0
PU MAIK NAUKA-INTERPERIODICA
PI MOSCOW
PA PROFSOYUZNAYA UL 90, MOSCOW, 117997, RUSSIA
SN 1990-7508
EI 1990-7516
J9 BIOCHEM MOSC SUPPL B
JI Biochem. Mosc.-Suppl. Ser. B-Biomed. Chem.
PD JUN
PY 2024
VL 18
IS 2
BP 174
EP 184
DI 10.1134/S199075082360022X
PG 11
WC Biochemistry & Molecular Biology
WE Emerging Sources Citation Index (ESCI)
SC Biochemistry & Molecular Biology
GA D8Z8H
UT WOS:001299017400002
DA 2025-06-11
ER

PT J
AU Bataller-Sifre, R
   Guiral-Olivan, V
   Bataller-Alberola, L
AF Bataller-Sifre, Ramon
   Guiral-Olivan, Victoria
   Bataller-Alberola, Luis
TI New clinical and toxicological scenario of gammaglutamyltranspeptidase
SO REVISTA ESPANOLA DE ENFERMEDADES DIGESTIVAS
LA English
DT Article
DE Gammaglutamyltranspeptidase; Glutathione; Oxidative stress; Enzyme
   induction; Chronic hepatopathies; Diabetes mellitus; Environmental
   toxins; Cardiovascular risk
ID TRANSFERASE TRANSPEPTIDASE; SERUM
AB After the discovery of gammaglutamyltranspeptidase in 1950 by Hanes, the significance of its increased levels in clinical practice has mainly been focused on ethanol toxicity, and also some neoplasms and biliary tract obstruction.
   More recently, attention has swift to the metabolic functions of this enzyme, as a neutralizer of oxygen free radicals and as a glutathione donor to the cell. High serum levels of gamma-glutamyltranspeptidase is known to occur when oxidative stress is increased, or associated with several vascular risk factors and the insulin resistance syndrome, as an early marker of diabetes.
   There are also a number of drugs that induce the expression of the tissue enzyme (microsomes) with the result of high serum levels without structural damage to the liver. Because it is a ubiquitous enzyme, a very high number of causes can be involved, that may be difficult to recognize.
   Finally, because glutathione is necessary to conjugate a number of chemical compounds, from an epidemiological and toxicological perspective, the enzyme might be useful as a biomarker of several ambient toxins.
   In this review we want to emphasize the increasing clinical and diagnostic significance of this enzyme discovered half a century ago.
C1 [Bataller-Sifre, Ramon] Valencian Community, Valencia, Spain.
   [Guiral-Olivan, Victoria] Hosp Clin Univ, Dept Internal Med, Valencia, Spain.
   [Bataller-Alberola, Luis] Hosp Univ La Fe, Dept Neurol, Valencia, Spain.
C3 Hospital Universitari i Politecnic La Fe
RP Bataller-Sifre, R (corresponding author), C Gran Via Marques del Turia 52, Valencia 46005, Spain.
EM ramon.bataller@uv.es
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NR 46
TC 7
Z9 8
U1 0
U2 3
PU ARAN EDICIONES, S A
PI MADRID
PA CASTELLO, 128, 28006 MADRID, SPAIN
SN 1130-0108
EI 2340-4167
J9 REV ESP ENFERM DIG
JI Rev. Esp. Enferm. Dig.
PD NOV
PY 2011
VL 103
IS 11
BP 586
EP 589
DI 10.4321/S1130-01082011001100006
PG 4
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA V34GT
UT WOS:000209075600006
PM 22149561
OA gold
DA 2025-06-11
ER

PT J
AU Bagger, JP
   Thomassen, A
   Nielsen, TT
AF Bagger, JP
   Thomassen, A
   Nielsen, TT
TI Cardiac energy metabolism in patients with chest pain and normal
   coronary angiograms
SO AMERICAN JOURNAL OF CARDIOLOGY
LA English
DT Article
ID ANGINA-PECTORIS; ARTERY DISEASE; MYOCARDIAL-METABOLISM; LACTATE
   PRODUCTION; PACING STRESS; SYNDROME-X; ARTERIOGRAMS; HEMODYNAMICS;
   ISCHEMIA; ALANINE
AB In 70 patients (94% were a consecutive series) with angina pectoris and normal coronary angiograms, we measured cardiac exchange of lactate, glucose, free fatty acids (FFAs), glutamate, alanine, citrate, and oxygen together with coronary sinus blood flow and blood pressure in response to pacing (150 beats/min). Twelve patients had an abnormal exercise stress test; 26 developed ST depression and 46 had chest pain in response to pacing. Sixteen patients had no ST changes (exercise/pacing) and no pain during pacing. Pacing induced an increase in cardiac carbohydrate extraction and a decrease in FFA extraction in the entire group of patients. Less than 3% of patients had significant cardiac lactate release in response to pacing, and there were no consistent differences in the cardiac metabolic or hemodynamic responses between patient groups. The pacing-induced shift from FFA to carbohydrate extraction probably reflects the cardiac response to an acute workload. A definite sign of cardiac ischemia (lactate production) was a rare finding in these patients and not confined to the demonstration of electrocardiographic signs of ischemia. (C)2000 by Excerpta Medico, Inc.
C1 Univ London Imperial Coll Sci Technol & Med, Sch Med, Hammersmith Hosp, Cardiothorac Directorate, London W12 0NN, England.
   Skejby Univ Hosp, Dept Cardiol, Aarhus, Denmark.
C3 Imperial College London; Aarhus University
RP Bagger, JP (corresponding author), Univ London Imperial Coll Sci Technol & Med, Sch Med, Hammersmith Hosp, Cardiothorac Directorate, Du Cane Rd, London W12 0NN, England.
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NR 25
TC 9
Z9 9
U1 0
U2 0
PU EXCERPTA MEDICA INC
PI NEW YORK
PA 245 WEST 17TH STREET, NEW YORK, NY 10011 USA
SN 0002-9149
J9 AM J CARDIOL
JI Am. J. Cardiol.
PD FEB 1
PY 2000
VL 85
IS 3
BP 315
EP 320
DI 10.1016/S0002-9149(99)00739-0
PG 6
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 278KW
UT WOS:000084989800007
PM 11078299
DA 2025-06-11
ER

PT J
AU Chen, C
   Zhao, CY
   Jin, HY
   Jiang, ZP
   Wang, W
   Li, WY
AF Chen, Chen
   Zhao, Chenyu
   Jin, Hongyu
   Jiang, Zhiping
   Wang, Wei
   Li, Wen-Yang
TI Association of composite dietary antioxidant index with circadian
   syndrome: evidence from NHANES
SO FRONTIERS IN NUTRITION
LA English
DT Article
DE composite dietary antioxidant index; dietary antioxidant; circadian
   syndrome; cross-sectional study; NHANES; restricted cubic spline
ID OXIDATIVE STRESS; METABOLIC SYNDROME; VITAMIN-A; SERUM ZINC; MEN;
   HOMEOSTASIS; EXERCISE; RHYTHM; ROS
AB Background The Circadian Syndrome (CircS) has been linked to various chronic diseases. However, the relationship between composite dietary antioxidant index (CDAI) and CircS has remained unexplored. This study aimed to investigate the potential association between CDAI and CircS.Methods Cross-sectional analyses were based on the National Health and Nutrition Examination Survey (NHANES) 2005-2018. Dietary consumption was assessed via the 24-h diet recall method and CDAI was computed following a validated approach involving six antioxidants. CircS was defined based on metabolic syndrome components, supplemented by short sleep duration and depressive symptoms. The relationship between CDAI and CircS was examined using weighted multivariable logistic regression and subgroup analyses. Additionally, restricted cubic spline (RCS) regression was employed to investigate potential nonlinear correlations.Results Among 11,048 subjects included (mean age 47.57 years), 2,733 (weighted prevalence = 22.13%) were reported to have CircS. Logistic regression revealed that the highest quartile of CDAI was inversely associated with the risk of CircS {odds ratio (OR) [95% CI = 0.69 (0.55-0.87)]} and the risk of depression [OR = 0.59 (0.48-0.72)], short sleep duration [OR = 0.54 (0.41-0.70)], elevated fasting glucose [OR = 0.80 (0.65-0.98)], elevated triglycerides (TG) [OR = 0.74 (0.59-0.92)], elevated waist circumference [OR = 0.65, (0.52-0.80)] and reduced high-density lipoprotein cholesterol (HDL-C) [OR = 0.75 (0.61-0.92)], respectively. A dose-response gradient in odds of CircS components was noted as CDAI levels increased, particularly with depression and short sleep duration. RCS showed a non-linear relationship between CDAI and CircS, with a U-shaped correlation found between Zinc and CircS (inflection point 12.63). Subgroup analysis showed BMI modified the inverse association between CDAI and CircS (p for interaction = 0.003).Conclusion This study revealed a non-linear and negative association between CDAI and CircS risk, with a U-shaped correlation observed between Zinc and CircS. Obese individuals might not benefit from excessively high CDAI. The results suggest that a higher CDAI score was correlated with a decreased risk of CircS.
C1 [Chen, Chen; Jin, Hongyu; Jiang, Zhiping; Wang, Wei; Li, Wen-Yang] China Med Univ, Resp & Crit Care Dept, Hosp 1, Shenyang, Peoples R China.
   [Zhao, Chenyu] China Med Univ, Dept China Med Univ, Queens Univ Belfast Joint Coll, Sch Pharm, Shenyang, Peoples R China.
C3 China Medical University; China Medical University
RP Li, WY (corresponding author), China Med Univ, Resp & Crit Care Dept, Hosp 1, Shenyang, Peoples R China.
EM 20122043@cmu.edu.cn
RI Zhao, Chenyu/MSZ-4264-2025; JIANG, Zhiping/ABB-8497-2021; li,
   wenyang/LVR-1826-2024
OI Chen, Chen/0009-0008-0510-1085; Zhao, Chenyu/0009-0007-9490-2062
FU National Natural Science Foundation of China [82370093]
FX The author(s) declare that financial support was received for the
   research, authorship, and/or publication of this article. This work was
   supported by the National Natural Science Foundation of China (no.
   82370093).
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NR 69
TC 0
Z9 0
U1 2
U2 2
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD JAN 3
PY 2025
VL 11
AR 1501352
DI 10.3389/fnut.2024.1501352
PG 15
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA S4D0P
UT WOS:001397736800001
PM 39830063
OA gold
DA 2025-06-11
ER

PT J
AU Çelik, ÖM
   Koçak, T
   Köksal, E
AF Celik, Ozge Mengi
   Kocak, Tevfik
   Koksal, Eda
TI Effects of Diurnal Ramadan Intermittent Fasting on Cardiometabolic Risk
   Factors and Sleep Quality in Healthy Turkish Adults
SO ECOLOGY OF FOOD AND NUTRITION
LA English
DT Article
DE Blood glucose; lipid profile; inflammatory cytokines; sleep quality;
   Ramadan fasting
ID BIOCHEMICAL PARAMETERS; HEMATOLOGICAL PARAMETERS; OXIDATIVE STRESS;
   BODY-WEIGHT; GLUCOSE; MARKERS
AB This study aimed to evaluate the effect of diurnal Ramadan fasting on cardiometabolic risk factors (blood glucose, lipid profile, inflammatory cytokines) and sleep quality in healthy Turkish adults. This prospective observational study was conducted with a total of 32 individuals (12 males, 20 females) who were aged between 19-32 years and fasted for 25 or more continuous days in Ankara, Turkey between 1 Ramadan 1442 and 30 Ramadan 1442. Individuals applied fasting for 16 hours in the spring season. Blood samples were taken after at least 8 hours of fasting, anthropometric measurements were taken and sleep quality was assessed using The Pittsburgh Sleep Quality Index (PSQI) at the beginning and the end of Ramadan. There was a significant decrease in body mass index (BMI), C-reactive protein (CRP), and tumor necrosis factor-alpha (TNF-alpha) levels during Ramadan fasting (p < .005). There were no changes in lipid profiles and sleep quality. There was a significant increase in fasting blood glucose levels (p < .05); however, this change is within normal limits. There was also a significant relationship between BMI and CRP, IL-6, and TNF-alpha levels (p < .05). The diurnal Ramadan fasting did not affect lipid profiles and sleep quality in healthy Turkish subjects. However, decreased BMI and inflammatory cytokine levels were observed at the end of Ramadan fasting. More studies are needed to clarify the role of Ramadan fasting in healthy populations.
C1 [Celik, Ozge Mengi] Trakya Univ, Fac Hlth Sci, Dept Nutr & Dietet, Edirne, Turkey.
   [Kocak, Tevfik; Koksal, Eda] Gazi Univ, Fac Hlth Sci, Dept Nutr & Dietet, Emek Biskek Cad 6 Sok Gazi Univ 2, TR-06490 Ankara, Cankaya, Turkey.
C3 Trakya University; Gazi University; Presidency Turkey
RP Koçak, T (corresponding author), Gazi Univ, Fac Hlth Sci, Dept Nutr & Dietet, Emek Biskek Cad 6 Sok Gazi Univ 2, TR-06490 Ankara, Cankaya, Turkey.
EM dyt_tevfik@hotmail.com
RI MENGİ ÇELİK, ÖZGE/AAU-7320-2020; Koksal, Eda/AAW-2900-2021; KOCAK,
   TEVFIK/GNP-0559-2022
OI KOCAK, TEVFIK/0000-0002-4096-6796; Mengi Celik,
   Ozge/0000-0002-0298-9591; KOKSAL, EDA/0000-0002-7930-9910
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NR 44
TC 6
Z9 6
U1 0
U2 8
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 0367-0244
EI 1543-5237
J9 ECOL FOOD NUTR
JI Ecol. Food Nutr.
PD SEP 3
PY 2022
VL 61
IS 5
BP 595
EP 607
DI 10.1080/03670244.2022.2089878
EA JUN 2022
PG 13
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 4I6NQ
UT WOS:000814633700001
PM 35730413
DA 2025-06-11
ER

PT J
AU Lehnen, AM
   Leguisamo, NM
   Dias, LD
   Pinto, GH
   Okamoto, NM
   Machado, UF
   Schaan, BD
AF Lehnen, A. M.
   Leguisamo, N. M.
   Dias, L. D.
   Pinto, G. H.
   Okamoto, N. M.
   Machado, U. F.
   Schaan, B. D.
TI Changes in Renal Glucose Transporters in an Animal Model of Metabolic
   Syndrome
SO HORMONE AND METABOLIC RESEARCH
LA English
DT Article
DE metabolic syndrome; glucose transporters; SHR; monosodium glutamate
ID DIABETIC-RATS; INSULIN-RESISTANCE; OXIDATIVE STRESS; RESPONSE ELEMENT;
   GENE-EXPRESSION; GLUT2 GENE; OBESITY; KIDNEY; IDENTIFICATION; SODIUM
AB Considering the similarity between structural, hemodynamic, and functional changes of obesity-related renal disease and diabetic nephropathy, we hypothesized that renal glucose transporter changes occur in obesity as in diabetes. The aim of the work was to evaluate GLUT1 and GLUT2 in kidneys of an animal model of metabolic syndrome. Neonate spontaneously hypertensive rats (SHR), n=15/group, were treated with monosodium glutamate (5 mg/g) (MetS) for 9 days and compared with saline-treated Wistar-Kyoto (C) and SHR (H) rats. Lee index, systolic arterial pressure (SAP), glycemia, insulin resistance, triglycerides, and HDL cholesterol were evaluated at 3 and 6 months. Medullar GLUT1 and cortical GLUT2 were analyzed by Western blot. MetS vs. C and H rats had the highest Lee index (p<0.001) and insulin resistance (3-months C: 4.3 +/- 0.7, H: 3.9 +/- 0.9, MetS: 2.7 +/- 0.6; 6-months C: 4.2 +/- 0.6, H: 3.8 +/- 0.5, MetS: 2.4 +/- 0.6% min(-1), p<0.001), similar glycemia, and the lowest HDL-cholesterol at 6-months (p<0.001). In the MetS and H rats, SAP was higher vs. C at 3-months (p<0.001) and 6-months (C: 151 +/- 15, H: 190 +/- 11, MetS: 185 +/- 13 mm Hg, p<0.001) of age. GLUT1 was ? 13x lower (p<0.001) at 3-months, reestablishing its content at 6-months in MetS group, while GLUT2 was 2x higher (p<0.001) in this group at 6-months of age. Renal GLUT1 and GLUT2 are modulated in kidney of rats with metabolic syndrome, where obesity, insulin resistance and hypertension coexist, despite normoglycemia. Like in diabetes, cortical GLUT2 overexpression may contribute to the development of kidney disease.
C1 [Lehnen, A. M.; Schaan, B. D.] Univ Fed Rio Grande do Sul, Hosp Clin Porto Alegre, Serv Endocrinol, BR-90046900 Porto Alegre, RS, Brazil.
   [Okamoto, N. M.; Machado, U. F.] Univ Sao Paulo, Inst Ciencias Biomed, Dept Fisiol & Biofis, BR-05508 Sao Paulo, Brazil.
C3 Universidade Federal do Rio Grande do Sul; Hospital de Clinicas de Porto
   Alegre; Universidade de Sao Paulo
RP Lehnen, AM (corresponding author), Inst Cardiol Rio Grande Do Sul, Av Princesa Isabel 395 Santana, BR-90620001 Porto Alegre, RS, Brazil.
EM amlehnen@terra.com.br
RI Lehnen, Alexandre/Q-3459-2016; Machado, Ubiratan/F-3096-2017; Schaan,
   Beatriz/I-7518-2017
OI Leguisamo, Natalia/0000-0002-1869-9329; Schaan,
   Beatriz/0000-0002-2128-8387
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NR 30
TC 4
Z9 6
U1 0
U2 8
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0018-5043
EI 1439-4286
J9 HORM METAB RES
JI Horm. Metab. Res.
PD OCT
PY 2013
VL 45
IS 11
BP 840
EP 843
DI 10.1055/s-0033-1354381
PG 4
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 234ZV
UT WOS:000325684600011
PM 24062089
DA 2025-06-11
ER

PT J
AU Kök Kendirlioglu, B
   Yüksel Öksüz, Ö
   Kalelioglu, T
   Sözen, S
   Ünalan Özperçin, P
   Cihnioglu, R
   Karamustafalioglu, N
AF Kok Kendirlioglu, Burcu
   Yuksel Oksuz, Ozge
   Kalelioglu, Tevfik
   Sozen, Sule
   Unalan Ozpercin, Pelin
   Cihnioglu, Refik
   Karamustafalioglu, Nesrin
TI The Role of Resolvin D1 in Indicating Chronic Inflammation and Axonal
   Damage in Bipolar Disorder: A Comparative Study of Manic and Depressive
   Episodes
SO NOROPSIKIYATRI ARSIVI-ARCHIVES OF NEUROPSYCHIATRY
LA English
DT Article
DE Axonal degeneration; bipolar disorder; metabolic syndrome;
   neuroinflammation; resolvin D1
ID DOCOSAHEXAENOIC ACID; FATTY-ACIDS; DEFICITS; D2; RESPONSES; STRESS
AB Introduction: Bipolar disorder (BD) is a chronic disorder associated with significant psychiatric morbidity and disability. Recent research has linked inflammatory processes to the pathology of BD. Resolvin D1 (RvD1), an anti-inflammatory molecule derived from eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), has been shown to inhibit apoptosis and neuroinflammation, and promote neurogenesis. This study aims to determine changes in serum RvD1 levels between acute episode and euthymic periods in patients with BD and their association with inflammatory and metabolic syndrome (MetS) parameters. Methods: This prospective clinical study was conducted with patients diagnosed with BD-I according to SCID-5. Patients whose serum RvD1 levels were assessed during manic and depressive episodes in the previous study were invited to return to the study after at least 8 weeks, when they had reached the euthymic period. Blood samples for RvD1, C-reactive protein (CRP), and hemogram tests were collected during both acute episodes and remission periods. Results: The study included 32 patients in manic episodes, 27 in depressive episodes, and 41 healthy controls, with no significant age difference amongthe groups. RvD1 levels decreased significantly from manic episodes to complete remission period (p=0.017, z=-2.391) during follow-up. The decrease from depression to remission was not statistically significant. Serum RvD1 levels in patients with depressive episodes in remission remained high in the control group (p=0.581, z=-0.553). During the followup period, white blood cell (p=0.009, z=-2.606) and neutrophil (p=0.007, z=-2.693) in mania period and CRP values in depression period (p=0.004, z=-2.880) were found to have decreased statistically. Conclusions: The study indicates that serum RvD1 levels are elevated during manic and depressive episodes in BD patients compared to healthy controls and decrease significantly during the remission period in patients with manic episode. We propose the potential utility of RvD1 as a diagnostic marker for identifying manic and depressive states. We can assume that there is an inflammatory process in BD in which RvD1 also plays a role. Further research is needed to explore the therapeutic potential of targeting RvD1 pathways in BD treatment.
C1 [Kok Kendirlioglu, Burcu] Maltepe Univ, Fac Med, Dept Psychiat, Istanbul, Turkiye.
   [Yuksel Oksuz, Ozge] Erenkoy Mental Hlth Res & Training Hosp, Dept Psychiat, Istanbul, Turkiye.
   [Kalelioglu, Tevfik] Univ Virginia, Sch Med, Dept Psychiat, Charlottesville, VA USA.
   [Sozen, Sule] Balikli Rum Hosp, Dept Psychiat, Istanbul, Turkiye.
   [Unalan Ozpercin, Pelin] Iskenderun State Hosp, Dept Psychiat, Hatay, Turkiye.
   [Cihnioglu, Refik] Istinye Univ Liv Hosp, Dept Psychiat, Istanbul, Turkiye.
   [Karamustafalioglu, Nesrin] Bakirkoy Mental Hlth Res & Training Hosp, Dept Psychiat, Istanbul, Turkiye.
C3 Maltepe University; Erenkoy Mental & Neurological Disorders Education &
   Research Hospital; University of Virginia; Hatay Iskenderun State
   Hospital; Ankara Liv Hospital; Istinye University; Istanbul Bakirkoy
   Mental Health & Neurology Training & Research Hospital
RP Kök Kendirlioglu, B (corresponding author), Maltepe Univ, Fac Med, Dept Psychiat, Istanbul, Turkiye.
EM kokburcu@gmail.com
RI Kök Kendirlioğlu, Burcu/ABB-1983-2021
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NR 42
TC 0
Z9 0
U1 3
U2 3
PU  TURKISH NEUROPSYCHIATRY ASSOC-TURK NOROPSIKIYATRI  DERNEGI
PI ISTANBUL
PA MESRUTIYET MAH HALASKARGAZI CAD SITE APT NO 128-1 SISLI, ISTANBUL,
   Turkiye
SN 1300-0667
EI 1309-4866
J9 NOROPSIKIYATRI ARS
JI Noropsikiyatri Ars.
PD MAR
PY 2025
VL 62
IS 1
BP 3
EP 10
DI 10.29399/npa.28891
PG 8
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA Z1R1T
UT WOS:001436755800002
PM 40046207
DA 2025-06-11
ER

PT J
AU Sugiyama, F
   Kobayashi, N
   Ishikawa, M
   Onoda, S
   Ishimitsu, T
AF Sugiyama, Fumihiro
   Kobayashi, Naohiko
   Ishikawa, Mayuko
   Onoda, Sho
   Ishimitsu, Toshihiko
TI Renoprotective mechanisms of telmisartan on renal injury and
   inflammation in SHRSP.Z-Lepr<SUP>fa</SUP>/IzmDmcr rats
SO CLINICAL AND EXPERIMENTAL NEPHROLOGY
LA English
DT Article
DE Telmisartan; Metabolic syndrome; Nephrosclerosis
ID SENSITIVE HYPERTENSIVE-RATS; TYPE-2 DIABETIC-RATS; RHO-KINASE INHIBITOR;
   ANGIOTENSIN-II; METABOLIC SYNDROME; RECEPTOR BLOCKADE; PODOCYTE INJURY;
   CARDIAC-PERFORMANCE; CELL-PROLIFERATION; OXIDATIVE STRESS
AB SHRSP.Z-Lepr(fa)/IzmDmcr (SHRSP fatty) rats create a new animal model of metabolic syndrome. However, the renoprotective effect of telmisartan therapy and its underlying mechanisms in SHRSP fatty rats remain unknown. We evaluate the effects of long-term telmisartan therapy on renal dysfunction, podocyte injury, inflammation, and transforming growth factor-beta 1 (TGF-beta 1)/Smad, epithelial-mesenchymal transition (EMT), mitogen-activated protein kinase (MAPK), Rho-kinase, and cell-cycle progression pathway in the renal cortex of SHRSP fatty rats.
   Seven-week-old male SHRSP fatty rats were treated with vehicle, telmisartan, and hydralazine for 8 weeks. Age-matched male Wistar-Kyoto/Izumo rats served as a control group.
   Vehicle-treated SHRSP fatty rats developed proteinuria and renal dysfunction, which in the telmisartan group was less than the vehicle and hydralazine group without changing blood pressure. Glomerulosclerosis and interstitial fibrosis were impaired in SHRSP fatty rats, and the renal damage in the telmisartan group was less than the vehicle and hydralazine groups. Decreased expression of nephrin and podocin and increased desmin-positive area in SHRSP fatty rats were restored by telmisartan but not hydralazine. TGF-beta 1/Smad, EMT marker, MAPK, Rho-kinase, and cell-cycle progression pathways were upregulated in SHRSP fatty rats, and these increased proteins in the telmisartan group were less than the vehicle and hydralazine group. Telmisartan administration resulted in significant suppression in tumor necrosis factor-alpha expression and nuclear factor-kappa B phosphorylation.
   Long-term telmisartan therapy may improve renal dysfunction, glomerulosclerosis, podocyte injury, and inflammation associated with EMT, TGF-beta/Smad, MAPK, Rho-kinase pathway in SHRSP fatty rats. Thus, telmisartan may have significant therapeutic potential for metabolic syndrome.
C1 [Sugiyama, Fumihiro; Kobayashi, Naohiko; Ishikawa, Mayuko; Onoda, Sho; Ishimitsu, Toshihiko] Dokkyo Med Univ, Sch Med, Dept Cardiol & Nephrol, Mibu, Tochigi 3210293, Japan.
C3 Dokkyo Medical University
RP Kobayashi, N (corresponding author), Dokkyo Med Univ, Sch Med, Dept Cardiol & Nephrol, Mibu, Tochigi 3210293, Japan.
EM nao-koba@dokkyomed.ac.jp
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NR 33
TC 11
Z9 14
U1 0
U2 4
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1342-1751
EI 1437-7799
J9 CLIN EXP NEPHROL
JI Clin. Exp. Nephrol.
PD AUG
PY 2013
VL 17
IS 4
BP 515
EP 524
DI 10.1007/s10157-012-0759-3
PG 10
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 206HW
UT WOS:000323511000006
PM 23268284
DA 2025-06-11
ER

PT J
AU Nishida, H
   Sohara, E
   Nomura, N
   Chiga, M
   Alessi, DR
   Rai, T
   Sasaki, S
   Uchida, S
AF Nishida, Hidenori
   Sohara, Eisei
   Nomura, Naohiro
   Chiga, Motoko
   Alessi, Dario R.
   Rai, Tatemitsu
   Sasaki, Sei
   Uchida, Shinichi
TI Phosphatidylinositol 3-Kinase/Akt Signaling Pathway Activates the
   WNK-OSR1/SPAK-NCC Phosphorylation Cascade in Hyperinsulinemic db/db Mice
SO HYPERTENSION
LA English
DT Article
DE WNK; PI3K; Akt; NaCl cotransporter; insulin; obesity; sodium; dependent
   hypertension
ID NA+-CL-COTRANSPORTER; BLOOD-PRESSURE; INSULIN SENSITIVITY; METABOLIC
   SYNDROME; DIETARY SALT; KINASE-B; IN-VIVO; SODIUM; HYPERTENSION;
   INHIBITOR
AB Metabolic syndrome patients have insulin resistance, which causes hyperinsulinemia, which in turn causes aberrant increased renal sodium reabsorption. The precise mechanisms underlying this greater salt sensitivity of hyperinsulinemic patients remain unclear. Abnormal activation of the recently identified with-no-lysine kinase (WNK)-oxidative stress-responsive kinase 1 (OSR1)/STE20/SPS1-related proline/alanine-rich kinase (SPAK)-NaCl cotransporter (NCC) phosphorylation cascade results in the salt-sensitive hypertension of pseudohypoaldosteronism type II. Here, we report a study of renal WNK-OSR1/SPAK-NCC cascade activation in the db/db mouse model of hyperinsulinemic metabolic syndrome. Thiazide sensitivity was increased, suggesting greater activity of NCC in db/db mice. In fact, increased phosphorylation of OSR1/SPAK and NCC was observed. In both Spak(T243A/+) and Osr1(T185A/+) knock-in db/db mice, which carry mutations that disrupt the signal from WNK kinases, increased phosphorylation of NCC and elevated blood pressure were completely corrected, indicating that phosphorylation of SPAK and OSR1 by WNK kinases is required for the increased activation and phosphorylation of NCC in this model. Renal phosphorylated Akt was increased in db/db mice, suggesting that increased NCC phosphorylation is regulated by the phosphatidylinositol 3-kinase/Akt signaling cascade in the kidney in response to hyperinsulinemia. A phosphatidylinositol 3-kinase inhibitor (NVP-BEZ235) corrected the increased OSR1/SPAK-NCC phosphorylation. Another more specific phosphatidylinositol 3-kinase inhibitor (GDC-0941) and an Akt inhibitor (MK-2206) also inhibited increased NCC phosphorylation. These results indicate that the phosphatidylinositol 3-kinase/Akt signaling pathway activates the WNK-OSR1/SPAK-NCC phosphorylation cascade in db/db mice. This mechanism may play a role in the pathogenesis of salt-sensitive hypertension in human hyperinsulinemic conditions, such as the metabolic syndrome. (Hypertension. 2012; 60: 981-990.). Online Data Supplement
C1 [Sohara, Eisei] Tokyo Med & Dent Univ, Grad Sch Med & Dent Sci, Dept Nephrol, Bunkyo Ku, Tokyo 1138519, Japan.
   [Alessi, Dario R.] Univ Dundee, Coll Life Sci, Med Res Council, Prot Phosphorylat Unit, Dundee, Scotland.
C3 Institute of Science Tokyo; Tokyo Medical & Dental University (TMDU);
   University of Dundee
RP Sohara, E (corresponding author), Tokyo Med & Dent Univ, Grad Sch Med & Dent Sci, Dept Nephrol, Bunkyo Ku, 1-5-45 Yushima, Tokyo 1138519, Japan.
EM esohara.kid@tmd.ac.jp
RI Rai, Tatemitsu/K-7165-2019; Alessi, Dario/JFS-5796-2023
OI Nomura, Naohiro/0000-0002-6998-1922; Alessi, Dario/0000-0002-2140-9185
FU Ministry of Education, Culture, Sports, Science, and Technology of
   Japan; Japan Society for the Promotion of Science; Salt Science Research
   Foundation [1228]; Takeda Science Foundation; Kanae Foundation for the
   Promotion of Medical Science; Nakajima Foundation; Grants-in-Aid for
   Scientific Research [24790836, 22390168, 22249032] Funding Source:
   KAKEN; MRC [MC_U127070193] Funding Source: UKRI
FX This study was supported in part by Grants-in-Aid for Scientific
   Research on Priority Areas from the Ministry of Education, Culture,
   Sports, Science, and Technology of Japan; Grants-in-Aid for Scientific
   Research on Creative Scientific Research from the Japan Society for the
   Promotion of Science; Grant-in-Aid for Scientific Research (A) from the
   Japan Society for the Promotion of Science; Grant-in-Aid for Young
   Scientists (B) from the Ministry of Education, Culture, Sports, Science,
   and Technology of Japan; the Salt Science Research Foundation (1228);
   Takeda Science Foundation; Kanae Foundation for the Promotion of Medical
   Science; and the Nakajima Foundation.
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NR 53
TC 78
Z9 82
U1 0
U2 7
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0194-911X
EI 1524-4563
J9 HYPERTENSION
JI Hypertension
PD OCT
PY 2012
VL 60
IS 4
BP 981
EP +
DI 10.1161/HYPERTENSIONAHA.112.201509
PG 22
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 006IF
UT WOS:000308812000022
PM 22949526
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Dwivedi, AK
   Jang, D
   Belkin, O
   Aickareth, J
   Renteria, M
   Hawwar, M
   Croft, J
   Kalas, MA
   Zuckerman, M
   Zhang, J
AF Dwivedi, Alok K.
   Jang, David
   Belkin, Ofek
   Aickareth, Justin
   Renteria, Mellisa
   Hawwar, Majd
   Croft, Jacob
   Kalas, M. Ammar
   Zuckerman, Marc
   Zhang, Jun
TI Metabolic Syndrome and Hemorrhagic Stroke in Hispanic Elderly Patients
   with Cerebral Cavernous Malformations
SO DIAGNOSTICS
LA English
DT Article
DE cerebral cavernous malformations (CCMs); metabolic syndrome; risk
   factors; hemorrhagic stroke; Mexican Hispanics
ID CARDIOVASCULAR RISK; OXIDATIVE STRESS; DISEASE SEVERITY; PATHOGENESIS;
   INFLAMMATION; HYPERTENSION; ASSOCIATION; PREVALENCE; HISTORY; IMPACT
AB Background/Objectives: Cerebral cavernous malformations (CCMs) are neurological disorders that increase the risk of hemorrhagic stroke. The Mexican Hispanic population has a higher prevalence of both CCMs and metabolic syndrome (MetS), defined by the presence of three or more of the following: central obesity, elevated triglycerides, low HDL, dyslipidemia, hypertension, or elevated fasting glucose. MetS is also associated with an increased risk of hemorrhagic stroke. However, the connection between MetS and hemorrhagic stroke in Hispanic CCM patients remains uncertain. Additionally, it is unclear if Hispanic CCM patients have different cardiometabolic profiles compared to controls. Methods: We analyzed a retrospective cohort of Mexican Hispanic adult CCM patients, including age- and gender-matched controls from the NHANES database. Fisher's exact test or an unpaired Student's t-test was used to compare risk factors between the CCM cohort and controls. Additionally, we conducted relative risk regression analysis to assess the adjusted association of MetS with hemorrhagic stroke. Results: The CCM cohort showed higher rates of epilepsy (24.6% vs. 1.6%, p < 0.001) and hemorrhagic stroke (36.6% vs. 3.6%, p < 0.001), but a lower prevalence of MetS (14% vs. 54.8%, p < 0.001) compared to age- and gender-matched Mexican Hispanic controls. The adjusted analysis revealed that among CCM patients in the older age group (age >= 50 years), MetS was associated with hemorrhagic stroke (RR = 2.38, 95%CI: 1.40-4.02, p = 0.001). Conclusions: This study reveals distinct features of CCMs in the Mexican Hispanic population, indicating a higher risk of hemorrhagic stroke and epilepsy compared to other ethnic groups. To mitigate the risk of hemorrhagic stroke, controlling blood pressure and managing comorbidities like metabolic syndrome (MetS) and epilepsy are essential, particularly in CCM patients aged 50 years and above.
C1 [Dwivedi, Alok K.; Jang, David; Belkin, Ofek; Aickareth, Justin; Renteria, Mellisa; Hawwar, Majd; Croft, Jacob; Zhang, Jun] Texas Tech Univ Hlth Sci Ctr, Dept Mol, El Paso, TX 79905 USA.
   [Dwivedi, Alok K.; Jang, David; Belkin, Ofek; Aickareth, Justin; Renteria, Mellisa; Hawwar, Majd; Croft, Jacob; Zhang, Jun] Texas Tech Univ Hlth Sci Ctr, Dept Translat Med, El Paso, TX 79905 USA.
   [Kalas, M. Ammar; Zuckerman, Marc] Texas Tech Univ Hlth Sci Ctr, Dept Internal Med, El Paso, TX 79905 USA.
C3 Texas Tech University System; Texas Tech University Health Sciences
   Center El Paso; Texas Tech University System; Texas Tech University
   Health Sciences Center El Paso; Texas Tech University System; Texas Tech
   University Health Sciences Center El Paso
RP Zhang, J (corresponding author), Texas Tech Univ Hlth Sci Ctr, Dept Mol, El Paso, TX 79905 USA.; Zhang, J (corresponding author), Texas Tech Univ Hlth Sci Ctr, Dept Translat Med, El Paso, TX 79905 USA.
EM alok.dwivedi@ttuhsc.edu; jun.zhang2000@gmail.com
RI Zhang, Jun/G-9091-2017; Croft, Jacob/JDD-7285-2023
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NR 38
TC 0
Z9 0
U1 0
U2 0
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2075-4418
J9 DIAGNOSTICS
JI Diagnostics
PD APR 30
PY 2025
VL 15
IS 9
AR 1144
DI 10.3390/diagnostics15091144
PG 11
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 2NN1F
UT WOS:001486863700001
PM 40361966
DA 2025-06-11
ER

PT J
AU Park, S
   Ham, JO
   Lee, BK
AF Park, Sunmin
   Ham, Jung-O.
   Lee, Byung-Kook
TI Effects of total vitamin A, vitamin C, and fruit intake on risk for
   metabolic syndrome in Korean women and men
SO NUTRITION
LA English
DT Article
DE Vitamin C intake; Vitamin A intake; Antioxidants; Metabolic syndrome;
   Sex
ID NUTRITION EXAMINATION SURVEY; OXIDATIVE STRESS; SERUM CAROTENOIDS;
   NATIONAL-HEALTH; PREVALENCE; ASSOCIATION; ANTIOXIDANTS; POPULATION;
   VEGETABLES; COMPONENTS
AB Objectives: The question of whether the consumption of antioxidants prevents and alleviates metabolic syndrome (MetS) by reducing insulin resistance remains controversial. The aim of this study was to assess whether the intake of vitamin A (including beta-carotene), vitamin C, fruits, or vegetables was negatively associated with MetS in Korean adults aged >= 20 y.
   Methods: We conducted a cross-sectional study of 27,656 adults >= 20 y of age who participated in the 2007-2012 Korean National Health and Nutrition Examination Survey. Daily intake of vitamin A and vitamin C was assessed by 24-h recall, and the consumption of fruits and vegetables was determined using a food frequency questionnaire. Odds ratios (ORs) for MetS were calculated for log(2)-transformed vitamin A and C intake values and for the interaction of sex with vitamin A and C intake, after covariate adjustment.
   Results: Interactions were seen between total vitamin A and C intake and sex for MetS. With a twofold increase in total vitamin A and C intake in women, the ORs (95% confidence intervals) for metabolic syndrome were 0.942 (0.901-0.985) and 0.933 (0.883-0.987), indicating decreases of 5.8% and 6.7% in MetS, respectively. There were no equivalent decreases in men. Women in the second and highest tertiles of fruit intake exhibited 17.5% and 21.8% lower incidences of MetS, respectively, compared with women in the lowest tertile.
   Conclusions: The intake of total vitamin A and C, as well as moderate and high fruit intake, may have alleviated MetS in women, but not in men, in a representative sample of the general South Korean population. (C) 2015 Elsevier Inc. All rights reserved.
C1 [Park, Sunmin] Hoseo Univ, Dept Food & Nutr, Asan, Chungnam Do, South Korea.
   [Ham, Jung-O.] Soonchunhyang Univ Hosp, Dept Occupat & Environm Med, Cheonan, South Korea.
   [Lee, Byung-Kook] Korea Ind Hlth Assoc, Seoul, South Korea.
C3 Hoseo University; Soonchunhyang University; Soonchunhyang University
   Hospital
RP Lee, BK (corresponding author), Korea Ind Hlth Assoc, Seoul, South Korea.
EM Bklee@kiha21.or.kr
OI Park, Sunmin/0000-0002-6092-8340
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NR 39
TC 75
Z9 78
U1 0
U2 20
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0899-9007
EI 1873-1244
J9 NUTRITION
JI Nutrition
PD JAN
PY 2015
VL 31
IS 1
BP 111
EP 118
DI 10.1016/j.nut.2014.05.011
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA AX1CJ
UT WOS:000346685600016
PM 25466654
DA 2025-06-11
ER

PT J
AU Ceriello, A
AF Ceriello, Antonio
TI Thiazolidinediones as anti-inflammatory and anti-atherogenic agents
SO DIABETES-METABOLISM RESEARCH AND REVIEWS
LA English
DT Review
DE pioglitazone; rosiglitazone; free radicals; oxidative stress;
   anti-inflammatory; anti-atherogenic
ID TUMOR-NECROSIS-FACTOR; C-REACTIVE PROTEIN; INTIMA-MEDIA THICKNESS;
   ACTIVATED-RECEPTOR-GAMMA; TYPE-2 DIABETIC-PATIENTS; HUMAN
   ADIPOSE-TISSUE; PIOGLITAZONE CLINICAL-TRIAL; INSULIN-RESISTANCE
   SYNDROME; IMPAIRED GLUCOSE-TOLERANCE; CORONARY-ARTERY-DISEASE
AB in the last few years, there has been increasing focus on the impact of interventions on cardiovascular outcomes in patients with type 2 diabetes. Insulin resistance and hyperglycaemia often co-exist with a cluster of risk factors for coronary artery disease, but the underlying mechanisms leading to the development of such vascular complications are complex. The overproduction of free radicals in patients suffering from diabetes results in a state of oxidative stress, which leads to endothelial dysfunction and a greater risk of atherosclerosis. Moreover, inflammatory factors which play a critical role in atherothrombosis and plaque rupture are often found to be at elevated levels in this patient population.
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C1 Univ Hosp, Warwick Med Sch, Clin Sci Res Inst, Coventry CV2 2DX, W Midlands, England.
C3 University of Warwick
RP Ceriello, A (corresponding author), Univ Hosp, Warwick Med Sch, Clin Sci Res Inst, Clin Sci Bldg,Walsgrave Campus, Coventry CV2 2DX, W Midlands, England.
EM antonio.ceriello@warwick.ac.uk
RI Ceriello, Antonio/J-9575-2016
OI Ceriello, Antonio/0000-0001-8122-3203
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   2007, N ENGL J MED
NR 154
TC 83
Z9 95
U1 0
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1520-7552
EI 1520-7560
J9 DIABETES-METAB RES
JI Diabetes-Metab. Res. Rev.
PD JAN-FEB
PY 2008
VL 24
IS 1
BP 14
EP 26
DI 10.1002/dmrr.790
PG 13
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 254HI
UT WOS:000252577300002
PM 17990280
DA 2025-06-11
ER

PT J
AU Nyakudya, TT
   Isaiah, S
   Ayeleso, A
   Ndhlala, AR
   Mukwevho, E
   Erlwanger, KH
AF Nyakudya, Trevor Tapiwa
   Isaiah, Simon
   Ayeleso, Ademola
   Ndhlala, Ashwell Rungano
   Mukwevho, Emmanuel
   Erlwanger, Kennedy Honey
TI Short-Term Neonatal Oral Administration of Oleanolic Acid Protects
   against Fructose-Induced Oxidative Stress in the Skeletal Muscles of
   Suckling Rats
SO MOLECULES
LA English
DT Article
DE oleanolic acid; oxidative damage; neonatal programming; metabolic
   syndrome; oxidative stress; anti-oxidant enzymes; high fructose
ID DIETARY FRUCTOSE; BIRTH-WEIGHT; LIVER-INJURY; BONE-GROWTH; BODY-WEIGHT;
   OBESITY; ANTIOXIDANT; DYSFUNCTION; YOUNG; NRF2
AB Nutritional manipulations in the neonatal period are associated with the development of negative or positive health outcomes later in life. Excessive fructose consumption has been attributed to the increase in the global prevalence of metabolic syndrome (MetS) and the development of oxidative stress. Oleanolic acid (OA) has anti-diabetic and anti-obesity effects. We investigated the protective potential of orally administering OA in the neonatal period, to prevent fructose-induced oxidative stress, adverse health outcomes and maturation of the gastrointestinal tract (GIT) in suckling rats. Seven-day old Sprague-Dawley rats (N = 30) were gavaged daily with 10 mL/kg of: distilled water (DW), oleanolic acid (OA; 60 mg/kg), high fructose solution (HF; 20% w/v), or OAHF for 7 days. On day 14, tissue samples were collected to determine clinical health profiles, hepatic lipid content, and activity of anti-oxidant enzymes. Furthermore, biomarkers of oxidative stress and anti-oxidant capacity in the skeletal muscles were assessed. The gastrointestinal tract (GIT) morphometry was measured. Rats in all groups grew over the 7-day treatment period. There were no significant differences in the terminal body masses, GIT morphometry, surrogate markers of general health, liver lipid content across all treatment groups (p < 0.05). Neonatal fructose administration decreased the activity of catalase, depleted GSH and increased lipid peroxidation. However, the level of GSH and catalase activity were improved by neonatal OA treatment. Short-term oral OA administration during the critical developmental period protects against fructose-induced oxidative stress without adverse effects on health outcomes associated with MetS or precocious development of the GIT in suckling male and female rats.
C1 [Nyakudya, Trevor Tapiwa] Univ Johannesburg, Fac Hlth Sci, Dept Human Anat & Physiol, ZA-2028 Johannesburg, South Africa.
   [Isaiah, Simon; Mukwevho, Emmanuel] North West Univ, Dept Biochem, Fac Nat Sci & Agr, ZA-2735 Mafikeng, Mmabatho, South Africa.
   [Ayeleso, Ademola] Adeleke Univ, Dept Biochem, Fac Sci, PMB 250, Ede 232, Osun State, Nigeria.
   [Ndhlala, Ashwell Rungano] Agr Res Council, VOP, Private Bag X293, ZA-0001 Pretoria, South Africa.
   [Erlwanger, Kennedy Honey] Univ Witwatersrand, Fac Hlth Sci, Sch Physiol, ZA-2193 Johannesburg, South Africa.
C3 University of Johannesburg; North West University - South Africa;
   Agricultural Research Council of South Africa; University of
   Witwatersrand
RP Ndhlala, AR (corresponding author), Agr Res Council, VOP, Private Bag X293, ZA-0001 Pretoria, South Africa.
EM trevorn@uj.ac.za; salmonovic@gmail.com; ademola.ayeleso@gmail.com;
   NdhlalaA@arc.agric.za; Emmanuel.Mukwevho@nwu.ac.za;
   Kennedy.Erlwanger@wits.ac.za
RI Mukwevho, Emmanuel/G-8962-2014; Erlwanger, Kennedy/AAX-2616-2020;
   Ndhlala, Ashwell/B-6595-2009; Nyakudya, Trevor/ABD-7926-2021
OI Nyakudya, Trevor/0000-0003-1872-9257; ISAIAH, SIMON/0000-0002-7471-3877;
   Mukwevho, Emmanuel/0000-0001-8800-955X
FU Faculty of Health Sciences Research Committee of the University of the
   Witwatersrand, Johannesburg; National Research Foundation of South
   Africa; Department of Higher Education and Training; University of
   Johannesburg, Department of Human Anatomy and Physiology
FX The authors wish to acknowledge the Faculty of Health Sciences Research
   Committee of the University of the Witwatersrand, Johannesburg, the
   National Research Foundation of South Africa and, the Department of
   Higher Education and Training for funding the research. The University
   of Johannesburg, Department of Human Anatomy and Physiology is also
   appreciated for financial support.
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NR 95
TC 9
Z9 9
U1 0
U2 3
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1420-3049
J9 MOLECULES
JI Molecules
PD FEB 2
PY 2019
VL 24
IS 4
AR 661
DI 10.3390/molecules24040661
PG 19
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA HO3FS
UT WOS:000460805900007
PM 30781794
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Gianotti, A
   Marin, V
   Cardone, G
   Bordoni, A
   Mancini, E
   Magni, M
   Pichler, A
   Ciani, S
   Polenghi, O
   Cerne, VL
   Nissen, L
AF Gianotti, Andrea
   Marin, Veronica
   Cardone, Gaetano
   Bordoni, Alessandra
   Mancini, Elisa
   Magni, Martina
   Pichler, Andrea
   Ciani, Silvano
   Polenghi, Ombretta
   Cerne, Virna Lucia
   Nissen, Lorenzo
TI Personalized and precise functional assessment of innovative flatbreads
   toward the colon microbiota of people with metabolic syndrome: Results
   from an in vitro simulation
SO FOOD RESEARCH INTERNATIONAL
LA English
DT Article
DE Tailored-food; Food by-products; Plant-based antioxidant; Fortification;
   Clinical nutrition; In vitro gut model
ID GUT MICROBIOTA; FOOD; MECHANISMS; GENERATION; BACTERIA; STRESS
AB Due to the increasing incidence of individuals with metabolic syndrome and the higher correlations between metabolic syndrome and the gut microbiota, there is a need to formulate functional foods that can promote the development of beneficial microorganisms within the gut microbiota. This study aims to evaluate the possible positive effects of innovative gluten-free flatbread, containing grape and apple antioxidant-rich by-products, on the gut microbiota of patients with metabolic syndrome. The baked products were subjected to gastric digestion using the Infogest system, followed by proximal colonic fermentation in the MICODE (Multi-Unit In vitro Colon Model) intestinal model, where three samplings were performed (baseline, after 16 h and 24 h). The samples were then subjected to 16S rRNA metataxonomy, quantification of shifts in bacterial populations by qPCR analysis and characterization of volatile organic compounds by SPME GC-MS (Solid Phase Micro Extraction Gas-Chromatography Mass-Spectrophotometry). A robust statistical approach based on several tests and multivariate analysis was applied. The results obtained demonstrated the in vitro potential of functional flatbreads in improving the dysbiosis of the microbiota of individuals with metabolic syndrome, due to a reduction in the Firmicutes/Bacteroidota ratio, and highlighted an increase in commensal microorganisms (Bifidobacterium, positive clostridia and Akkermansia muciniphila) and a reduction in negative microorganisms (Enterobacteriaceae, negative clostridia and Collinsella spp.). The analysis of metabolites showed an increase in health-beneficial metabolites (acetate and medium chain organic acids) and a reduction in harmful metabolites (p-cresol and skatole), the degree of this modulation varied based on the flatbread composition. While this study employed an in vitro model of recognized limitations, it nonetheless provides valuable, evidence-based results that can be used for preclinical screening of formulations. Anyhow this work is of high fashion in this running time as it proposes i) in vitro models rather than animal testing; ii) human MetS gut microbiota for high translatability to in vivo condition; iii) approaches of precise and personalized nutrition by the use of specific microbiota and omic technologies, all component that vow to be the future of food assessment.
C1 [Gianotti, Andrea; Bordoni, Alessandra; Nissen, Lorenzo] Univ Bologna, Alma Mater Studiorum, DISTAL Dept Agr & Food Sci, Food Sci Campus Pza G Goidanich 60, I-47521 Cesena, Italy.
   [Gianotti, Andrea; Bordoni, Alessandra; Nissen, Lorenzo] Alma Mater Studiorum Univ Bologna, CIRI Interdept Ctr Agrifood Ind Res, Pza G Goidanich 60, I-47521 Cesena, Italy.
   [Marin, Veronica; Cardone, Gaetano; Ciani, Silvano; Polenghi, Ombretta; Cerne, Virna Lucia] Dr Schar R&D Ctr, Area Sci Pk Padriciano 99, I-34149 Trieste, Italy.
   [Mancini, Elisa] Private Nutr Clin, Piazza Polesani nel Mondo 16, I-45100 Boara Polesine, RO, Italy.
   [Magni, Martina; Pichler, Andrea] Laimburg Res Ctr, Auer, BZ, Italy.
C3 University of Bologna; University of Bologna; Laimburg Research Center
RP Gianotti, A (corresponding author), Univ Bologna, Alma Mater Studiorum, DISTAL Dept Agr & Food Sci, Food Sci Campus Pza G Goidanich 60, I-47521 Cesena, Italy.
EM andrea.gianotti@unibo.it
RI Nissen, Lorenzo/AAF-6534-2020; Gianotti, Andrea/Y-3887-2019
FU Autonomous Province of Bozen/Bolzano
FX This research was partially founded by Autonomous Province of
   Bozen/Bolzano in the context of the project entitled "REAliSM"
   Regionalita ed. Eco-circolarita in ALImenti per contrastare la Sindrome
   Metabolica (Regionalism and eco-circularity in food to counteract
   Metabolic Syndrome).
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NR 65
TC 0
Z9 0
U1 3
U2 3
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0963-9969
EI 1873-7145
J9 FOOD RES INT
JI Food Res. Int.
PD MAY
PY 2025
VL 209
AR 116197
DI 10.1016/j.foodres.2025.116197
PG 13
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA 1KP3S
UT WOS:001467252700001
PM 40253173
DA 2025-06-11
ER

PT J
AU Shabbir, MA
   Mehak, F
   Khan, ZM
   Ahmad, W
   Khan, MR
   Zia, S
   Rahaman, A
   Aadil, RM
AF Shabbir, Muhammad Asim
   Mehak, Fakiha
   Khan, Zaira Mumal
   Ahmad, Waqar
   Khan, Moazzam Rafiq
   Zia, Sania
   Rahaman, Abdul
   Aadil, Rana Muhammad
TI Interplay between ceramides and phytonutrients: New insights in
   metabolic syndrome
SO TRENDS IN FOOD SCIENCE & TECHNOLOGY
LA English
DT Article
DE Ceramides; Metabolic syndrome; Phytonutrients; Sphingolipids; Obesity
ID INDUCED INSULIN-RESISTANCE; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS;
   CORONARY-ARTERY-DISEASE; SPHINGOLIPID METABOLISM; RECEPTOR SUBSTRATE-1;
   PROTEIN PHOSPHATASE; PLASMA CERAMIDES; SIGNALING AXIS; HIGH-FAT;
   INFLAMMATION
AB Background: Ceramides are a novel biomarker for numerous obesity-associated disorders such as type II diabetes mellitus (T2D) and atherosclerosis. Ceramides were considered as a relatively homogeneous class of sphingolipids. Ceramides generally have a wide length of the fatty acyl chain that take part in different metabolic processes. Modulation of ceramide synthesis in certain cellular components along with its metabolism has a significant influence on metabolic homeostasis.
   Scope and approach: In this review, major role of ceramides in metabolic syndrome and the ability of certain phytonutrients to manage ceramides levels have been discussed. Ceramides act as an intracellular signaling molecules that affect the metabolism through different pathways such as adiposity linkage, insulin resistance and cardiometabolic syndrome. In addition, phytonutrients are novel therapeutic agents that may lower plasma ceramide levels involved in metabolic syndrome. Furthermore, relationship between ceramides and metabolic syndrome with regards to ceramide modulation and effect of bioactive phytonutrients in regulating the ceramides levels in relation to obesity-associated disorders is also elucidated.
   Key findings and conclusions: The unique structure enables ceramides to function both as structural membrane components and signaling molecules Accumulation of ceramides and their coalescence in sphingolipid-rich domains can influence cell signaling by clustering receptors. As sum of all the ceramide species present in cells usually range from 0.1 to 1.0% of total phospholipids yet may have high affinity targets. Different ceramides species usually with long n-acyl chains have been implicated in pathophysiologic processes and disease progression. Ceramides slowed lipolysis, inhibited glucose uptake, and decreased mitochondrial respiration. Certain cytokines including tumor necrosis factor alpha (TNF?) and interleukins (ILs) such as IL-1b and adiponectin, activate the sphingomyelinase enzymes. Besides inflammatory signals, ceramide production is often stimulated by oxidative stress. From literature, lipidomic analysis revealed that nutritional intervention (consuming plantbased foods as a source of phytonutrients) can help in lowering the circulating ceramides especially C16:0 and C24:0 ceramides, a potential known inhibitor of insulin signaling. However, exact mechanism of different phytonutrients involved in ceramide modulation needs to be understood at molecular level for gaining more insights at their mechanistic mode of action.
C1 [Shabbir, Muhammad Asim; Mehak, Fakiha; Khan, Zaira Mumal; Ahmad, Waqar; Khan, Moazzam Rafiq; Zia, Sania; Aadil, Rana Muhammad] Univ Agr Faisalabad, Natl Inst Food Sci & Technol, Faisalabad, Pakistan.
   [Rahaman, Abdul] South China Univ Technol, Sch Food Sci & Engn, Guangzhou 510640, Guangdong, Peoples R China.
C3 University of Agriculture Faisalabad; South China University of
   Technology
RP Khan, MR; Aadil, RM (corresponding author), Univ Agr Faisalabad, Natl Inst Food Sci & Technol, Faisalabad, Pakistan.
EM mrkhan_ft@yahoo.com; dilrana89@gmail.com
RI Rahaman, Abdul/T-1834-2019; Zia, Sania/AAV-6365-2020; Khan, Muhammad
   Amir/JEZ-6363-2023; Shabbir, Muhammad/M-8681-2018; Khan, Muhammad
   Azzam/KCZ-1774-2024; Ahmed, Waqar/JPA-2138-2023; Aadil, Rana
   Muhammad/GRY-2404-2022
OI Aadil, Rana Muhammad/0000-0002-0185-0096; Ahmed,
   Waqar/0000-0002-0373-3897; Zia, Sania/0000-0003-0425-1766
FU University of Agriculture, Faisalabad, Pakistan
FX The authors are grateful to University of Agriculture, Faisalabad,
   Pakistan for the support.
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NR 107
TC 10
Z9 10
U1 2
U2 20
PU ELSEVIER SCIENCE LONDON
PI LONDON
PA 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND
SN 0924-2244
EI 1879-3053
J9 TRENDS FOOD SCI TECH
JI Trends Food Sci. Technol.
PD MAY
PY 2021
VL 111
BP 483
EP 494
DI 10.1016/j.tifs.2021.03.010
EA MAR 2021
PG 12
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA RN9XE
UT WOS:000640705100001
DA 2025-06-11
ER

PT J
AU Guo, ZJ
   Peng, YH
   Hu, QY
   Liu, N
   Liu, Q
AF Guo, Zhijiao
   Peng, Yanhui
   Hu, Qiaoyu
   Liu, Na
   Liu, Qing
TI The relationship between leptin and periodontitis: a literature review
SO PEERJ
LA English
DT Review
DE Leptin; Periodontitis; Mechanism; Inflammatory cytokines
ID SERUM LEPTIN; CIRCULATING LEPTIN; METABOLIC SYNDROME; OXIDATIVE STRESS;
   ASSOCIATION; ADIPONECTIN; LEVEL; INFLAMMATION; EXPRESSION; OBESITY
AB Leptin is a peptide hormone that regulates energy balance, immune inflammatory response, and bone metabolism. Several studies have demonstrated a relationship between leptin and periodontitis, a local inflammatory disease that progressively weakens the supporting structures of the teeth, eventually leading to tooth loss. This article reviews the existing literature and discusses leptin's basic characteristics, its relationship with periodontitis, and its effects on periodontal tissue metabolism.
C1 [Guo, Zhijiao; Peng, Yanhui; Hu, Qiaoyu; Liu, Qing] Hebei Med Univ, Sch & Hosp Stomatol, Hebei Clin Res Ctr Oral Dis, Hebei Key Lab Stomatol, Shijiazhuang, Hebei, Peoples R China.
   [Liu, Na] Hebei Med Univ, Sch & Hosp Stomatol, Dept Prevent Dent, Shijiazhuang, Hebei, Peoples R China.
C3 Hebei Medical University; Hebei Medical University
RP Liu, Q (corresponding author), Hebei Med Univ, Sch & Hosp Stomatol, Hebei Clin Res Ctr Oral Dis, Hebei Key Lab Stomatol, Shijiazhuang, Hebei, Peoples R China.; Liu, N (corresponding author), Hebei Med Univ, Sch & Hosp Stomatol, Dept Prevent Dent, Shijiazhuang, Hebei, Peoples R China.
EM ynlqdx@sina.com; kqliuqing@sina.com
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NR 62
TC 1
Z9 1
U1 1
U2 9
PU PEERJ INC
PI LONDON
PA 341-345 OLD ST, THIRD FLR, LONDON, EC1V 9LL, ENGLAND
SN 2167-8359
J9 PEERJ
JI PeerJ
PD DEC 15
PY 2023
VL 11
AR e16633
DI 10.7717/peerj.16633
PG 13
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA CR6Y6
UT WOS:001127021400003
PM 38111655
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Zhao, XJ
   Yang, YZ
   Zheng, YJ
   Wang, SC
   Gu, HM
   Pan, Y
   Wang, SJ
   Xu, HJ
   Kong, LD
AF Zhao, Xiao-Juan
   Yang, Yan-Zi
   Zheng, Yan-Jing
   Wang, Shan-Chun
   Gu, Hong-Mei
   Pan, Ying
   Wang, Shui-Juan
   Xu, Hong-Jiang
   Kong, Ling-Dong
TI Magnesium isoglycyrrhizinate blocks fructose-induced hepatic NF-κB/NLRP3
   inflammasome activation and lipid metabolism disorder
SO EUROPEAN JOURNAL OF PHARMACOLOGY
LA English
DT Article
DE Magnesium isoglycyrrhizinate; Fructose-induced metabolic syndrome; Liver
   injury; Immunological-inflammatory and metabolic; profile; NF-kappa
   B/NLRP3 inflammasome activation
ID ACCUMULATION; SUPPLEMENTATION; PATHWAYS; OBESITY; STRESS; CELLS
AB Magnesium isoglycyrrhizinate as a hepatoprotective agent possesses immune modulation and anti-inflammation, and treats liver diseases. But its effects on immunological-inflammatory and metabolic profiles for metabolic syndrome with liver injury and underlying potential mechanisms are not fully understood. In this study, magnesium isoglycyrrhizinate alleviated liver inflammation and lipid accumulation in fructose-fed rats with metabolic syndrome. It also suppressed hepatic inflammatory signaling activation by reducing protein levels of phosphorylation of nuclear factor-kappa B p65 (p-NF-kappa B p65), inhibitor of nuclear factor kappa-B kinase alpha/beta (p-IKK alpha/beta) and inhibitor of NF-kappa B alpha (p-I kappa B alpha) as well as nucleotide-binding domain (NOD)-like receptor protein 3 (NLRP3), apoptosis-associated speck-like protein (ASC) and Caspase-1 in rats, being consistent with its reduction of interleulan-1 beta (IL-1 beta, tumor necrosis factor-a (TNF-alpha) and IL-6 levels. Furthermore, magnesium isoglycyrrhizinate modulated lipid metabolism-related genes characterized by up-regulating peroxisome proliferator-activated receptor-alpha (PPAR-alpha) and carnitine palmitoyl transferase-1 (CPT-1), and down-regulating sensor for fatty acids to control-1 (SREBP-1) and stearoyl-CoA desaturase 1 (SCD-1) in the liver of fructose-fed rats, resulting in the reduction of triglyceride and total cholesterol levels. These effective actions were further confirmed in fructose-exposed BRL-3A and HepG2 cells. The molecular mechanisms underpinning these observations suggest that magnesium isoglycyrrhizinate may inhibit NF-kappa B/NLRP3 inflammasome activation to reduce immunological-inflammatory response, which in turn may prevent liver lipid metabolic disorder and accumulation under high fructose condition. Thus, blockade of NF-kappa B/NLRP3 inflammasome activation and lipid metabolism disorder by magnesium isoglycyrrhizinate may be the potential therapeutic approach for improving fructose-induced liver injury with metabolic syndrome in clinic.
C1 [Zhao, Xiao-Juan; Yang, Yan-Zi; Zheng, Yan-Jing; Pan, Ying; Wang, Shui-Juan; Kong, Ling-Dong] Nanjing Univ, Sch Life Sci, State Key Lab Pharmaceut Biotechnol, Nanjing 210023, Jiangsu, Peoples R China.
   [Wang, Shan-Chun; Gu, Hong-Mei; Xu, Hong-Jiang] Chia Tai Tianqing Pharmaceut Grp Co LTD, Drug Screening & Evaluat Dept R&D Inst, Nanjing 210023, Jiangsu, Peoples R China.
C3 Nanjing University
RP Kong, LD (corresponding author), Nanjing Univ, Sch Life Sci, State Key Lab Pharmaceut Biotechnol, Nanjing 210023, Jiangsu, Peoples R China.; Xu, HJ (corresponding author), Chia Tai Tianqing Pharmaceut Grp Co LTD, Drug Screening & Evaluat Dept R&D Inst, Nanjing 210023, Jiangsu, Peoples R China.
EM 13915987463@163.com; kongld@nju.edu.cn
FU Natural Science Foundation of Jiangsu Province [BK20141243]
FX This work was supported by Natural Science Foundation of Jiangsu
   Province (Grant No. BK20141243).
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NR 34
TC 59
Z9 62
U1 1
U2 51
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0014-2999
EI 1879-0712
J9 EUR J PHARMACOL
JI Eur. J. Pharmacol.
PD AUG 15
PY 2017
VL 809
BP 141
EP 150
DI 10.1016/j.ejphar.2017.05.032
PG 10
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA EZ9JU
UT WOS:000405047400016
PM 28526339
DA 2025-06-11
ER

PT J
AU Saraf, R
   Huang, T
   Mahmood, F
   Owais, K
   Bardia, A
   Khabbaz, KR
   Liu, D
   Senthilnathan, V
   Lassaletta, AD
   Sellke, F
   Matyal, R
AF Saraf, Rabya
   Huang, Thomas
   Mahmood, Feroze
   Owais, Khurram
   Bardia, Amit
   Khabbaz, Kamal R.
   Liu, David
   Senthilnathan, Venkatachalam
   Lassaletta, Antonio D.
   Sellke, Frank
   Matyal, Robina
TI Early Cellular Changes in the Ascending Aorta and Myocardium in a Swine
   Model of Metabolic Syndrome
SO PLOS ONE
LA English
DT Article
ID ARTERIAL STIFFNESS; OXIDATIVE STRESS; NEUROPEPTIDE-Y; NITRIC-OXIDE;
   HYPERTENSION; APOPTOSIS; INFLAMMATION; MECHANISMS; PRESSURE; FIBROSIS
AB Background
   Metabolic syndrome is associated with pathological remodeling of the heart and adjacent vessels. The early biochemical and cellular changes underlying the vascular damage are not fully understood. In this study, we sought to establish the nature, extent, and initial time-line of cytochemical derangements underlying reduced ventriculo-arterial compliance in a swine model of metabolic syndrome.
   Methods
   Yorkshire swine (n = 8 per group) were fed a normal diet (ND) or a high-cholesterol (HCD) for 12 weeks. Myocardial function and blood flow was assessed before harvesting the heart. Immuno-blotting and immuno-histochemical staining were used to assess the cellular changes in the myocardium, ascending aorta and left anterior descending artery (LAD).
   Results
   There was significant increase in body mass index, blood glucose and mean arterial pressures (p = 0.002, p = 0.001 and p = 0.024 respectively) in HCD group. At the cellular level there was significant increase in anti-apoptotic factors p-Akt (p = 0.007 and p = 0.002) and Bcl-xL (p = 0.05 and p = 0.01) in the HCD aorta and myocardium, respectively. Pro-fibrotic markers TGF-beta (p = 0.01), pSmad1/5 (p = 0.03) and MMP-9 (p = 0.005) were significantly increased in the HCD aorta. The levels of pro-apoptotic p38MAPK, Apaf-1 and cleaved Caspase3 were significantly increased in aorta of HCD (p = 0.03, p = 0.04 and p = 0.007 respectively). Similar changes in coronary arteries were not observed in either group. Functionally, the high cholesterol diet resulted in significant increase in ventricular end systolic pressure and-dp/dt (p = 0.05 and p = 0.007 respectively) in the HCD group.
   Conclusion
   Preclinical metabolic syndrome initiates pro-apoptosis and pro-fibrosis pathways in the heart and ascending aorta, while sparing coronary arteries at this early stage of dietary modification.
C1 [Saraf, Rabya; Khabbaz, Kamal R.; Liu, David; Senthilnathan, Venkatachalam; Lassaletta, Antonio D.] Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Dept Surg,Div Cardiac Surg, Boston, MA 02215 USA.
   [Huang, Thomas; Mahmood, Feroze; Owais, Khurram; Bardia, Amit; Matyal, Robina] Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Dept Anesthesia Crit Care & Pain Med, Boston, MA 02215 USA.
   [Lassaletta, Antonio D.; Sellke, Frank] Rhode Isl Hosp, Brown Alpert Sch Med, Dept Surg, Providence, RI USA.
C3 Harvard University; Harvard Medical School; Harvard University Medical
   Affiliates; Beth Israel Deaconess Medical Center; Harvard University;
   Harvard Medical School; Harvard University Medical Affiliates; Beth
   Israel Deaconess Medical Center; Lifespan Health Rhode Island; Rhode
   Island Hospital; Brown University
RP Matyal, R (corresponding author), Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Dept Anesthesia Crit Care & Pain Med, Boston, MA 02215 USA.
EM rmatyal1@bidmc.harvard.edu
RI Liu, David R./HCH-3132-2022; Mahmood, Feroze/B-1383-2008
OI Huang, Thomas/0000-0001-7257-1134
FU Department of Anesthesia at Beth Israel Deaconess Medical Center; Ronald
   M. Weintraub Family Research Fund; NIH [R01 HL069024, RO1 HL46716]
FX This research was supported by the Department of Anesthesia at Beth
   Israel Deaconess Medical Center, the Ronald M. Weintraub Family Research
   Fund, and NIH grants R01 HL069024 and RO1 HL46716. The funders had no
   role in study design, data collection and analysis, decision to publish,
   or preparation of the manuscript.
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NR 44
TC 5
Z9 5
U1 0
U2 2
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JAN 14
PY 2016
VL 11
IS 1
AR e0146481
DI 10.1371/journal.pone.0146481
PG 18
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA DB4CC
UT WOS:000368459300022
PM 26766185
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Kang, YH
   Min, HK
   Son, SM
   Kim, IJ
   Kim, YK
AF Kang, Yang Ho
   Min, Hong Ki
   Son, Seok Man
   Kim, In Ju
   Kim, Yong Ki
TI The association of serum gamma glutamyltransferase with components of
   the metabolic syndrome in the Korean adults
SO DIABETES RESEARCH AND CLINICAL PRACTICE
LA English
DT Article
DE gamma glutamyltransferase; metabolic syndrome; insulin resistance;
   HOMA-IR
ID AGED JAPANESE MEN; BLOOD-CELL COUNT; GLUTAMYL-TRANSFERASE; INSULIN
   RESISTANCE; HEART-DISEASE; RISK-FACTORS; TRANSPEPTIDASE
AB The metabolic syndrome (MS) is a cluster of risk factors for cardiovascular disease related to insulin resistance. Recently, serum gamma glutamyltransferase (GGT) has been proposed as a marker of oxidative stress and is associated with a marked increase in the risk of cardiovascular disease. So, we investigated the association between serum GGT and components of the metabolic syndrome in the Korean adults.
   A total 3246 adults (aged 20-70 years, 1622 men and 1624 women) who visited Center for Health Promotion in Pusan National University Hospital for a medical checkup were included. We measured serum GGT and lipid profiles, fasting glucose, fasting insulin and blood pressure.
   As the quartile of serum GGT increased, the number of components of MS and prevalence of MS were increased. Serum GGT was also increased according as the number of components of MS was increased. A significant correlation (r = 0.200, p < 0.001 in men and r = 0.133, p < 0.001 in women) was noted between the numbers of the components of the MS and serum GGT. In addition, serum GGT was correlated significantly (r = 0.266, p < 0.001 in men and r = 0.264, p < 0.001 in women) with homeostasis model assessment of insulin resistance (HOMA-IR). In linear regression model, serum GGT was mainly influenced by the concentration of triglycerides and fasting glucose.
   In conclusion, serum GGT is closely related with insulin resistance and the increased number of components of MS. Among components of MS, serum GGT may be more associated with dyslipidemia and abnormal glucose tolerance, suggesting that serum GGT has more relationship with hepatic insulin resistance regardless of non-alcoholic fatty liver disease. (C) 2007 Published by Elsevier Ireland Ltd.
C1 Pusan Natl Univ, Sch Med, Dept Internal Med, Pusan 602739, South Korea.
   Pusan Natl Univ, Sch Med, Dept Family Med, Pusan 602739, South Korea.
C3 Pusan National University; Pusan National University Hospital; Pusan
   National University; Pusan National University Hospital
RP Son, SM (corresponding author), Pusan Natl Univ, Sch Med, Dept Internal Med, 1-10 Ami Dong, Pusan 602739, South Korea.
EM somsm@pusan.ac.kr
RI Min, Hong Ki/HLX-4792-2023; Kim, In-Ju/S-6408-2017; Kang, Yang
   Ho/C-7296-2018
OI Min, Hong Ki/0000-0003-1147-1046; Kang, Yang Ho/0000-0002-1215-7975
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NR 28
TC 53
Z9 54
U1 0
U2 0
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0168-8227
EI 1872-8227
J9 DIABETES RES CLIN PR
JI Diabetes Res. Clin. Pract.
PD AUG
PY 2007
VL 77
IS 2
BP 306
EP 313
DI 10.1016/j.diabres.2006.11.009
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 174EM
UT WOS:000246924100023
PM 17353063
DA 2025-06-11
ER

PT J
AU Urwyler, SA
   Schuetz, P
   Ebrahimi, F
   Donath, MY
   Christ-Crain, M
AF Urwyler, Sandrine Andrea
   Schuetz, Philipp
   Ebrahimi, Fahim
   Donath, Marc Y.
   Christ-Crain, Mirjam
TI Interleukin-1 Antagonism Decreases Cortisol Levels in Obese Individuals
SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Article
ID PITUITARY-ADRENAL AXIS; PHASE-I TRIAL; METABOLIC SYNDROME; WEIGHT-LOSS;
   CYTOKINES; RELEASE; INFLAMMATION; IL-1-BETA; HORMONES; STRESS
AB Context: Increased cortisol levels in obesity may contribute to the associated metabolic syndrome. In obesity, the activated innate immune system leads to increased interleukin (IL)-1 beta, which is known to stimulate the release of adrenocorticotropin hormone (ACTH).
   Objectives: We hypothesized that in obesity IL-1 antagonism would result in downregulation of the hypothalamo-pituitary-adrenal axis, leading to decreased cortisol levels.
   Design and Participants: In this prospective intervention study, we included 73 patients with obesity (body mass index [BMI] >= 30 kg/m(2)) and at least one additional feature of the metabolic syndrome.
   Outcome Measures: The primary end point was change in morning cortisol from baseline to after the administration of the IL-1 receptor antagonist (anakinra/Kineret (R), total dose 3 x 100 mg). Secondary end points were effects on salivary cortisol and ACTH.
   Results: Median age was 56 years, 50.7% of patients were female, and median BMI was 36.3 kg/m(2). Median morning serum cortisol levels (nmol/L) decreased significantly after IL-1 antagonism [from baseline, 452 to 423; absolute difference, -38.7; 95% confidence interval (CI), -64 to -13.4; P = 0.0019]. Similar effects were found for salivary cortisol levels (-2.8; 95% CI, -4.4 to -1.3; P = 0.0007), ACTH levels (-2.2; 95% CI; -4.2 to -0.1; P = 0.038), systolic blood pressure (-5.2, 95% CI, -8.5 to -1.8; P = 0.0006), and heart rate (-2.9; 95% CI,-4.7 to -1.0; P = 0.0029).
   Conclusion: IL-1 antagonism in obese individuals with features of the metabolic syndrome leads to a decrease in serum cortisol, salivary cortisol, and ACTH levels along with a reduction in systolic blood pressure and heart rate.
C1 [Urwyler, Sandrine Andrea; Ebrahimi, Fahim; Donath, Marc Y.; Christ-Crain, Mirjam] Univ Basel Hosp, Dept Endocrinol Diabetol & Metab, CH-4031 Basel, Switzerland.
   [Urwyler, Sandrine Andrea; Schuetz, Philipp; Ebrahimi, Fahim; Donath, Marc Y.; Christ-Crain, Mirjam] Univ Basel Hosp, Dept Clin Res, CH-4031 Basel, Switzerland.
   [Schuetz, Philipp] Kantonsspital Aarau, Dept Endocrinol, Med Univ Clin, CH-5001 Aarau, Switzerland.
C3 University of Basel; University of Basel; Kantonsspital Aarau AG (KSA)
RP Urwyler, SA (corresponding author), Univ Hosp, Petersgraben 4, CH-4031 Basel, Switzerland.
EM sandrine.urwyler@usb.ch
RI Ebrahimi, Fahim/JQI-5819-2023; Schuetz, Philipp/C-8475-2013
OI Christ-Crain, Mirjam/0000-0002-6336-0965; Schuetz,
   Philipp/0000-0001-6400-4949; Urwyler, Sandrine
   Andrea/0000-0003-4056-2262; Ebrahimi, Fahim/0000-0001-5862-966X
FU Swiss National Foundation [PP00P3-12346]; University Hospital Basel;
   University of Basel
FX This work was supported by the Swiss National Foundation (Grant no.
   PP00P3-12346) (to M.C.-C.), the "Wissenschaftspool 2014" of the
   University Hospital Basel (to S.A.U.), and the University of Basel
   (Nachwuchsforderung 2015) (to S.A.U.). The funding sources were neither
   involved in the design of the study nor in writing of the manuscript.
   The authors have no conflicts of interest to declare.
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NR 36
TC 18
Z9 19
U1 0
U2 6
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0021-972X
EI 1945-7197
J9 J CLIN ENDOCR METAB
JI J. Clin. Endocrinol. Metab.
PD MAY 1
PY 2017
VL 102
IS 5
BP 1712
EP 1718
DI 10.1210/jc.2016-3931
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA EW6IX
UT WOS:000402614700033
PM 28324042
OA Green Published, Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Bogh, HL
   Stanislaus, S
   Kjærstad, HL
   Sletved, KSO
   Forman, JL
   Poulsen, HE
   Vinberg, M
   Kessing, LV
   Coello, K
AF Bogh, Helena Lykke
   Stanislaus, Sharleny
   Kjaerstad, Hanne Lie
   Sletved, Kimie Stefanie Ormstrup
   Forman, Julie Lyng
   Poulsen, Henrik Enghusen
   Vinberg, Maj
   Kessing, Lars Vedel
   Coello, Klara
TI Associations between levels of oxidative nucleoside damage and
   cardiovascular risk in patients newly diagnosed with bipolar disorder
   and their unaffected relatives
SO TRANSLATIONAL PSYCHIATRY
LA English
DT Article
ID SUBCLINICAL ATHEROSCLEROSIS; STRESS MARKERS; GENERATED DNA;
   RATING-SCALE; RNA DAMAGE; DISEASE; PREVALENCE;
   8-OXO-7,8-DIHYDRO-2'-DEOXYGUANOSINE; METAANALYSIS; RELIABILITY
AB Enhanced oxidative stress-generated nucleoside damage may contribute to the increased cardiovascular disease mortality in patients with bipolar disorder (BD) but the association has never been investigated. We investigated the associations between oxidative stress-generated damage to DNA (8-oxodG) and RNA (8-oxoGuo), respectively, and three measures reflecting cardiovascular risk; namely, the Framingham 30-year risk score of cardiovascular diseases, the metabolic syndrome, and the insulin resistance index in 360 patients newly diagnosed with BD, 102 of their unaffected relatives (UR) and 197 healthy control individuals (HC). In sex- and age-adjusted models, the 30-year cardiovascular risk score increased by 20.8% (CI = 7.4-35.9%, p = 0.002) for every one nM/mM creatinine increase in 8-oxoGuo and by 15.6% (95% CI = 5.8-26.4%, p = 0.001) for every one nM/mM creatinine increase in 8-oxodG, respectively. Further, insulin resistance index increased by 24.1% (95% CI = 6.7-43%, p = 0.005) when 8-oxoGuo increased one nM/mM creatinine. The associations between cardiovascular measures and oxidative nucleoside damage were more pronounced in patients with BD compared with UR, and HC. Metabolic syndrome was not associated with nucleoside damage. Overall, higher oxidative stress-generated nucleoside damage was associated with a higher cardiovascular risk score and a higher degree of insulin resistance index, and having BD impacted the associations. Further, within patients, treatment with psychotropics seemed to enhance the associations between 30-year CVD risk score and insulin resistance index, respectively, and oxidatively stress-generated nucleoside damage. Our findings support enhanced oxidative stress-generated nucleoside damage as a putative pathophysiological mechanism that may mediate the higher cardiovascular risk observed in patients with BD already at the time of diagnosis.
C1 [Bogh, Helena Lykke; Stanislaus, Sharleny; Kjaerstad, Hanne Lie; Sletved, Kimie Stefanie Ormstrup; Vinberg, Maj; Kessing, Lars Vedel; Coello, Klara] Copenhagen Univ Hosp, Copenhagen Affect Disorders Res Ctr CADIC, Psychiat Ctr Copenhagen, Rigshosp, Copenhagen, Denmark.
   [Bogh, Helena Lykke; Sletved, Kimie Stefanie Ormstrup; Poulsen, Henrik Enghusen; Vinberg, Maj; Kessing, Lars Vedel] Univ Copenhagen, Dept Clin Med, Copenhagen, Denmark.
   [Forman, Julie Lyng] Univ Copenhagen, Dept Publ Hlth, Sect Biostat, Copenhagen, Denmark.
   [Poulsen, Henrik Enghusen] Copenhagen Univ Hosp Bispebjerg Frederiksberg, Dept Endocrinol, Frederiksberg, Denmark.
   [Poulsen, Henrik Enghusen] Copenhagen Univ Hosp North Zealand, Dept Cardiol, Hillerod, Denmark.
   [Poulsen, Henrik Enghusen] North Zealand Hosp Hillerd, Res Unit, Hillerod, Denmark.
   [Vinberg, Maj] Copenhagen Univ Hosp, Psychiat Ctr North Zealand, Psychiat Res Unit, Hillerod, Denmark.
C3 University of Copenhagen; Copenhagen University Hospital;
   Rigshospitalet; University of Copenhagen; University of Copenhagen;
   University of Copenhagen; Bispebjerg Hospital; University of Copenhagen;
   Copenhagen University Hospital
RP Coello, K (corresponding author), Copenhagen Univ Hosp, Copenhagen Affect Disorders Res Ctr CADIC, Psychiat Ctr Copenhagen, Rigshosp, Copenhagen, Denmark.
EM klara.coello@regionh.dk
RI Coello, Klara/AAZ-6545-2020; Kessing, Lars/JNS-2493-2023;
   Vinberg/ABC-7493-2021; Kjærstad, Hanne/IWD-9362-2023
OI Forman, Julie/0000-0001-7368-0869; Coello, Klara/0000-0003-1568-2991;
   Vinberg, Maj/0000-0002-5982-1335; Kessing, Lars/0000-0001-9377-9436;
   Kjaerstad, Hanne Lie/0000-0001-7781-8853
FU Mental Health Services, Capital Region of Denmark [164019]; Capital
   Region of Denmark; Augustinus Foundation; Danish Council for Independent
   Research, Medical Sciences [DFF-4183-00570]; A.P. MOller Foundation for
   the Advancement of Medical Science [15-55]; Beckett-Fonden [48282];
   Lundbeck Foundation
FX This study was supported by grants from the Mental Health Services,
   Capital Region of Denmark (PhD student 164019 and the BIO study), The
   Capital Region of Denmark, the Augustinus Foundation, The Danish Council
   for Independent Research, Medical Sciences (DFF-4183-00570), the A.P.
   MOller Foundation for the Advancement of Medical Science (15-55), and
   Beckett-Fonden (48282). Helena Lykke BOgh received a scholarship in
   psychiatry from The Lundbeck Foundation. We thank the laboratory of
   clinical pharmacology Rigshospitalet/Bispebjerg Frederiksberg Hospital
   for the 8-oxodG and 8-oxoGuo analysis
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NR 42
TC 7
Z9 7
U1 0
U2 1
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 2158-3188
J9 TRANSL PSYCHIAT
JI Transl. Psychiatr.
PD AUG 10
PY 2022
VL 12
IS 1
AR 327
DI 10.1038/s41398-022-02095-6
PG 10
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychiatry
GA 3R1AH
UT WOS:000838651100003
PM 35948543
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Fry, JL
   Al Sayah, L
   Weisbrod, RM
   Van Roy, I
   Weng, X
   Cohen, RA
   Bachschmid, MM
   Seta, F
AF Fry, Jessica L.
   Al Sayah, Leona
   Weisbrod, Robert M.
   Van Roy, Isabelle
   Weng, Xiang
   Cohen, Richard A.
   Bachschmid, Markus M.
   Seta, Francesca
TI Vascular Smooth Muscle Sirtuin-1 Protects Against Diet-Induced Aortic
   Stiffness
SO HYPERTENSION
LA English
DT Article
DE aorta; arterial stiffness; cardiovascular disease; metabolic syndrome;
   obesity; sirtuin-1; vascular smooth muscle
ID PULSE-WAVE VELOCITY; ARTERIAL STIFFNESS; CARDIOVASCULAR EVENTS; CALORIE
   RESTRICTION; BLOOD-PRESSURE; INCIDENT HYPERTENSION; SIRT1 DEACETYLASE;
   OXIDATIVE STRESS; CELL-SURVIVAL; HEART-DISEASE
AB Arterial stiffness, a major cardiovascular risk factor, develops within 2 months in mice fed a high-fat, high-sucrose (HFHS) diet, serving as a model of human metabolic syndrome, and it is associated with activation of proinflammatory and oxidant pathways in vascular smooth muscle (VSM) cells. Sirtuin-1 (SirT1) is an NAD+-dependent deacetylase regulated by the cellular metabolic status. Our goal was to study the effects of VSM SirT1 on arterial stiffness in the context of diet-induced metabolic syndrome. Overnight fasting acutely decreased arterial stiffness, measured in vivo by pulse wave velocity, in mice fed HFHS for 2 or 8 months, but not in mice lacking SirT1 in VSM (SMKO). Similarly, VSM-specific genetic SirT1 overexpression (SMTG) prevented pulse wave velocity increases induced by HFHS feeding, during 8 months. Administration of resveratrol or S17834, 2 polyphenolic compounds known to activate SirT1, prevented HFHS-induced arterial stiffness and were mimicked by global SirT1 overexpression (SirT1 bacterial artificial chromosome overexpressor), without evident metabolic improvements. In addition, HFHS-induced pulse wave velocity increases were reversed by 1-week treatment with a specific, small molecule SirT1 activator (SRT1720). These beneficial effects of pharmacological or genetic SirT1 activation, against HFHS-induced arterial stiffness, were associated with a decrease in nuclear factor kappa light chain enhancer of activated B cells (NF kappa B) activation and vascular cell adhesion molecule (VCAM-1) and p47phox protein expressions, in aorta and VSM cells. In conclusion, VSM SirT1 activation decreases arterial stiffness in the setting of obesity by stimulating anti-inflammatory and antioxidant pathways in the aorta. SirT1 activators may represent a novel therapeutic approach to prevent arterial stiffness and associated cardiovascular complications in overweight/obese individuals with metabolic syndrome.
C1 [Fry, Jessica L.; Al Sayah, Leona; Weisbrod, Robert M.; Van Roy, Isabelle; Weng, Xiang; Cohen, Richard A.; Bachschmid, Markus M.; Seta, Francesca] Boston Univ, Sch Med, Vasc Biol Sect, Med Campus, Boston, MA USA.
C3 Boston University
RP Seta, F (corresponding author), Boston Univ, Sch Med, Vasc Biol Sect, 650 Albany St,X726, Boston, MA 02118 USA.
EM setaf@bu.edu
RI Seta, Francesca/ABB-1566-2020; Stefanadis, Christodoulos/ABH-2232-2020
OI /0000-0002-1070-6408; Bachschmid, Markus Michael/0000-0002-0748-5528;
   Fry, Jessica/0000-0003-2748-0334; Seta, Francesca/0000-0001-7985-5615;
   Stefanadis, Christodoulos/0000-0001-5974-6454
FU NHLBI [HL105287]; Evans Center for Interdisciplinary Biomedical Research
   Arterial Stiffness Affinity Research Collaboratives (ARC) at Boston
   University; NIDDK [R01 DK103750]; Ruth Kirschstein Postdoctoral
   Fellowship at the Whitaker Cardiovascular Institute Multidisciplinary
   Training Program [T32 HL07224]; Marfan's Foundation Early Investigator
   grant; Boston University Evans Fellow award; Strategic Alliance; Servier
   Pharmaceutical Company
FX This work was supported by NHLBI R01 grant HL105287 and was partially
   supported by the Evans Center for Interdisciplinary Biomedical Research
   Arterial Stiffness Affinity Research Collaboratives (ARC) at Boston
   University (http://www.bumc.bu.edu/evanscenteribr/), NIDDK R01 DK103750
   grant, a Ruth Kirschstein Postdoctoral Fellowship T32 HL07224 at the
   Whitaker Cardiovascular Institute Multidisciplinary Training Program, a
   Marfan's Foundation Early Investigator grant, a Boston University Evans
   Fellow award, and a Strategic Alliance with Servier Pharmaceutical
   Company. This work was accomplished, in part, with the use of the Boston
   University Analytical Instrumentation Core.
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NR 50
TC 73
Z9 83
U1 0
U2 12
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0194-911X
EI 1524-4563
J9 HYPERTENSION
JI Hypertension
PD SEP
PY 2016
VL 68
IS 3
BP 775
EP +
DI 10.1161/HYPERTENSIONAHA.116.07622
PG 22
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA DT1ZK
UT WOS:000381280400034
PM 27432859
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Mizukawa, M
   Ohmori, K
   Obayashi, A
   Ishihara, Y
   Yoshida, J
   Noma, T
   Yukiiri, K
   Kosaka, H
   Kohno, M
AF Mizukawa, Mizuki
   Ohmori, Koji
   Obayashi, Ayumi
   Ishihara, Yasuhiro
   Yoshida, Junji
   Noma, Takahisa
   Yukiiri, Kazushi
   Kosaka, Hiroaki
   Kohno, Masakazu
TI Effects of combined olmesartan and pravastatin on glucose intolerance
   and cardiovascular remodeling in a metabolic-syndrome model
SO HYPERTENSION RESEARCH
LA English
DT Article
DE adiponectin; diabetes mellitus; dihydrofolate reductase; endothelial
   nitric oxide synthetase; oxidative stress
ID DIABETES-MELLITUS; PLASMA ADIPONECTIN; TYPE-1 RECEPTOR; ADIPOSE-TISSUE;
   RAT MODEL; ATORVASTATIN; OBESITY
AB Hypertension and dyslipidemia frequently coexist in patients with progressive insulin resistance and thus constitute metabolic syndrome. We sought to determine the merits of combining an angiotensin II receptor blocker and a 3-hydroxy-3-methylglutarylcoenzyme A reductase inhibitor in treating this pathological condition. Five-week-old Otsuka Long-Evans Tokushima Fatty rats, a model of metabolic syndrome, were untreated or treated with olmesartan 3 mg kg(-1) per day, pravastatin 30 mg kg(-1) per day or their combination for 25 weeks. Long-Evans Tokushima Otsuka rats served as normal controls. The antihypertensive effect of olmesartan and the lipid-lowering properties of pravastatin were both augmented by the combination. The oral glucose tolerance test revealed that only the combined treatment significantly reduced the area under the time-glucose curve, which was accompanied by augmented adiponectin messenger RNA expression in epididymal adipose tissue. Although the total cardiac endothelial nitric oxide synthetase ( eNOS) content did not significantly differ among the groups, the combined treatment significantly increased the content of dihydrofolate reductase, a key eNOS coupler. Dihydroethidium staining of the aorta showed that the combination most significantly attenuated superoxide production. Moreover, Azan-Mallory staining revealed that the combination most significantly limited the perivascular fibrosis and wall thickening of intramyocardial coronary arteries. In conclusion, the combination of olmesartan and pravastatin augmented adiponectin expression in white adipose tissue and improved glucose tolerance in a rat model of metabolic syndrome, which was associated with more significant ameliorations of cardiovascular redox state and remodeling than those by treatments with either agent alone. Hypertension Research ( 2009) 32, 617-624; doi: 10.1038/hr.2009.63; published online 22 May 2009
C1 [Mizukawa, Mizuki; Ohmori, Koji; Obayashi, Ayumi; Ishihara, Yasuhiro; Yoshida, Junji; Noma, Takahisa; Yukiiri, Kazushi; Kohno, Masakazu] Kagawa Univ, Fac Med, Dept Cardiorenal Cerebrovasc Med, Miki, Kagawa 7610793, Japan.
   [Kosaka, Hiroaki] Kagawa Univ, Fac Med, Dept Cardiovasc Physiol, Miki, Kagawa 7610793, Japan.
C3 Kagawa University; Kagawa University
RP Ohmori, K (corresponding author), Kagawa Univ, Fac Med, Dept Cardiorenal Cerebrovasc Med, 1750-1 Ikenobe, Miki, Kagawa 7610793, Japan.
EM komori@med.kagawa-u.ac.jp
FU Daiichi-Sankyo Co. Ltd., Tokyo, Japan; Otsuka Pharmaceutical Co. Ltd.,
   Tokyo, Japan
FX This work was partly supported by a research grant from Daiichi-Sankyo
   Co. Ltd., Tokyo, Japan. The authors are grateful to Otsuka
   Pharmaceutical Co. Ltd., Tokyo, Japan for providing the OLETF rats and
   LETO rats at no cost.
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NR 29
TC 10
Z9 14
U1 0
U2 0
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0916-9636
EI 1348-4214
J9 HYPERTENS RES
JI Hypertens. Res.
PD JUL
PY 2009
VL 32
IS 7
BP 617
EP 624
DI 10.1038/hr.2009.63
PG 8
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 466QQ
UT WOS:000267677800016
PM 19461650
OA Bronze
DA 2025-06-11
ER

PT J
AU Kaplan, Ö
   Meriç, M
   Acar, Z
   Kale, A
   Demircan, S
   Yilmaz, Ö
   Demircan, G
   Miroglu, YY
AF Kaplan, Ozgur
   Meric, Murat
   Acar, Zeydin
   Kale, Abdurrahman
   Demircan, Sabri
   Yilmaz, Ozcan
   Demircan, Gunnur
   Miroglu, Yeliz Yilmaz
TI The effect of exercise and antioxidant enzyme levels in syndrome X and
   coronary slow flow phenomenon: an observational study
SO ANADOLU KARDIYOLOJI DERGISI-THE ANATOLIAN JOURNAL OF CARDIOLOGY
LA English
DT Article
DE Coronary slow flow; syndrome X; antioxidant enzymes
ID CARDIAC SYNDROME-X; OXIDATIVE STRESS; ARTERY-DISEASE; ENDOTHELIAL
   FUNCTION; ANGINA-PECTORIS; ATHEROSCLEROSIS; HOMOCYSTEINE; MECHANISMS
AB Objective: In this study the antioxidant enzyme [catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx)] levels at rest in patients with syndrome X and coronary slow flow are measured. Then it has been investigated whether there is any enzymatic difference between the normal controls and syndrome X patients or patients with coronary slow flow and ascertain if exercise has any effects on the antioxidant enzyme levels.
   Methods: Fifty-five patients were included in this prospective observational controlled study. Patients were divided into 3 groups: Group 1-normal controls (n=20); Group 2-patients with coronary slow flow (n=20); and Group 3-patients diagnosed with syndrome X (n=15). In all patients, blood samples were collected at rest and after maximal exercise. The antioxidant enzymes (SOD, CAT, Gpx) in the erythrocytes were studied for these three groups of blood sample. Statistical analysis was performed using Student t-test, Mann-Whitney U and Chi-square tests, Kruskal-Wallis variance analysis and ANOVA.
   Results: Under basal conditions the lowest SOD and GPx levels were measured in the 2nd Group, whereas significant differences in paired comparisons were observed only between the 2nd and 3rd Groups (p=0.024 vs. p<0.01, respectively) during paired comparisons. The post-exercise SOD levels were decreased significantly in the 3rd Groups when compared with the basal concentrations (p=0.014), however no significant pre- and post-exercise differences were observed in the CAT and GPx concentrations (p>0.05).
   Conclusion: The post-exercise SOD level when compared with basal SOD levels were decreased significantly in the syndrome X group, however no differences were observed between the other groups. This can be interpreted as the reduction ischemic findings are resulting from the decrease of SOD activity.
C1 [Kaplan, Ozgur; Meric, Murat; Acar, Zeydin; Kale, Abdurrahman; Demircan, Sabri; Yilmaz, Ozcan] Ondokuz Mayis Univ, Fac Med, Dept Cardiol, Samsun, Turkey.
   [Demircan, Gunnur; Miroglu, Yeliz Yilmaz] Ondokuz Mayis Univ, Fac Med, Dept Biol, Samsun, Turkey.
C3 Ondokuz Mayis University; Ondokuz Mayis University
RP Kaplan, Ö (corresponding author), Malatya Devlet Hastanesi Beydagi Kampusu, Kardiyol Serv, Malatya, Turkey.
EM drozgurkaplan@yahoo.com
RI Mühendislik Fakültesi, Harran Üniversitesi/GXH-7079-2022; Demircan,
   Sabri/MSZ-6783-2025
CR Akyuz F, 1998, KLIN GELISIM, V11, P409
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NR 27
TC 4
Z9 4
U1 0
U2 8
PU AVES YAYINCILIK
PI FINDIKZADE
PA IBRAHIM KARA, KIZILELMA CAD 5-3, FINDIKZADE, ISTANBUL 34096, TURKEY
SN 1302-8723
EI 1308-0032
J9 ANADOLU KARDIYOL DER
JI Anadolu Kardiyol. Derg.
PD NOV
PY 2013
VL 13
IS 7
BP 641
EP 646
DI 10.5152/akd.2013.186
PG 6
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 256JG
UT WOS:000327305700003
PM 23912786
DA 2025-06-11
ER

PT J
AU Henkel, J
   Coleman, CD
   Schraplau, A
   Jöhrens, K
   Weber, D
   Castro, JP
   Hugo, M
   Schulz, TJ
   Krämer, S
   Schürmann, A
   Püschel, GP
AF Henkel, Janin
   Coleman, Charles Dominic
   Schraplau, Anne
   Joehrens, Korinna
   Weber, Daniela
   Castro, Jose Pedro
   Hugo, Martin
   Schulz, Tim Julius
   Kraemer, Stephanie
   Schuermann, Annette
   Pueschel, Gerhard Paul
TI Induction of Steatohepatitis (NASH) with Insulin Resistance in Wild-type
   B6 Mice by a Western-type Diet Containing Soybean Oil and Cholesterol
SO MOLECULAR MEDICINE
LA English
DT Article
ID FATTY LIVER-DISEASE; HEPATIC STEATOSIS; KUPFFER CELLS; INFLAMMATION;
   PATHOGENESIS; OBESE; HEPATOCYTES; INHIBITION; FIBROSIS; MODELS
AB Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) are hepatic manifestations of the metabolic syndrome. Many currently used animal models of NAFLD/NASH lack clinical features of either NASH or metabolic syndrome such as hepatic inflammation and fibrosis (e.g., high-fat diets) or overweight and insulin resistance (e.g., methionine-choline-deficient diets), or they are based on monogenetic defects (e.g., ob/ob mice). In the current study, a Western-type diet containing soybean oil with high n-6-PUFA and 0.75% cholesterol (SOD + Cho) induced steatosis, inflammation and fibrosis accompanied by hepatic lipid peroxidation and oxidative stress in livers of C57BL/6-mice, which in addition showed increased weight gain and insulin resistance, thus displaying a phenotype closely resembling all clinical features of NASH in patients with metabolic syndrome. In striking contrast, a soybean oil-containing Western-type diet without cholesterol (SOD) induced only mild steatosis but not hepatic inflammation, fibrosis, weight gain or insulin resistance. Another high-fat diet, mainly consisting of lard and supplemented with fructose in drinking water (LAD + Fru), resulted in more prominent weight gain, insulin resistance and hepatic steatosis than SOD + Cho, but livers were devoid of inflammation and fibrosis. Although both LAD + Fru-and SOD + Cho-fed animals had high plasma cholesterol, liver cholesterol was elevated only in SOD + Cho animals. Cholesterol induced expression of chemotactic and inflammatory cytokines in cultured Kupffer cells and rendered hepatocytes more susceptible to apoptosis. In summary, dietary cholesterol in the SOD + Cho diet may trigger hepatic inflammation and fibrosis. SOD + Cho-fed animals may be a useful disease model displaying many clinical features of patients with the metabolic syndrome and NASH.
C1 [Henkel, Janin; Coleman, Charles Dominic; Schraplau, Anne; Pueschel, Gerhard Paul] Univ Potsdam, Inst Nutr Sci, Dept Nutr Biochem, Arthur Scheunert Allee 114-116, D-14558 Nuthetal, Germany.
   [Joehrens, Korinna] Charite, Inst Pathol, Berlin, Germany.
   [Schulz, Tim Julius] German Inst Human Nutr, Dept Adipocyte Dev & Nutr, Nuthetal, Germany.
   [Kraemer, Stephanie] German Inst Human Nutr, Anim Facil, Nuthetal, Germany.
   [Schuermann, Annette] German Inst Human Nutr, Dept Expt Diabetol, Nuthetal, Germany.
   [Castro, Jose Pedro; Schulz, Tim Julius; Schuermann, Annette] German Ctr Diabet Res, Munich, Germany.
   [Weber, Daniela; Castro, Jose Pedro; Hugo, Martin] German Inst Human Nutr, Dept Mol Toxicol, Nuthetal, Germany.
   [Castro, Jose Pedro] Univ Porto, Dept Biomed, Fac Med, Oporto, Portugal.
   [Castro, Jose Pedro] Inst Innovat & Hlth Res, Aging & Stress Grp, Oporto, Portugal.
   [Weber, Daniela] NutriAct Competence Cluster Nutr Res Berlin Potsd, Nuthetal, Germany.
C3 University of Potsdam; Berlin Institute of Health; Free University of
   Berlin; Humboldt University of Berlin; Charite Universitatsmedizin
   Berlin; Leibniz Association; Deutsches Institut fur Ernahrungsforschung
   Potsdam-Rehbrucke (DIfE); Leibniz Association; Deutsches Institut fur
   Ernahrungsforschung Potsdam-Rehbrucke (DIfE); Leibniz Association;
   Deutsches Institut fur Ernahrungsforschung Potsdam-Rehbrucke (DIfE);
   German Center for Diabetes Research (DZD); Leibniz Association;
   Deutsches Institut fur Ernahrungsforschung Potsdam-Rehbrucke (DIfE);
   Universidade do Porto
RP Henkel, J (corresponding author), Univ Potsdam, Inst Nutr Sci, Dept Nutr Biochem, Arthur Scheunert Allee 114-116, D-14558 Nuthetal, Germany.
EM jhenkel@uni-potsdam.de
RI Hugo, Martín/AAW-8351-2020; Henkel, Janin/K-2063-2019; Schulz,
   Tim/F-4842-2013
OI Schurmann, Annette/0000-0002-4113-4377; Castro, Jose
   Pedro/0000-0002-2627-5331; Schulz, Tim/0000-0002-8413-3972; Hugo,
   Martin/0000-0003-3430-6457; Weber, Daniela/0000-0002-2054-6233
FU German Research Foundation [HE-7032/1-1]
FX This work was funded in part by the German Research Foundation (grant
   HE-7032/1-1).
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NR 54
TC 47
Z9 48
U1 0
U2 13
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1076-1551
EI 1528-3658
J9 MOL MED
JI Mol. Med.
PY 2017
VL 23
BP 70
EP 82
DI 10.2119/molmed.2016.00203
PG 13
WC Biochemistry & Molecular Biology; Cell Biology; Medicine, Research &
   Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology; Research & Experimental
   Medicine
GA EU4ER
UT WOS:000400983100004
PM 28332698
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Shi, J
   Yang, Z
   Niu, YX
   Zhang, WW
   Li, XY
   Zhang, HM
   Lin, N
   Gu, HX
   Wen, J
   Ning, G
   Qin, L
   Su, Q
AF Shi, Jie
   Yang, Zhen
   Niu, Yixin
   Zhang, Weiwei
   Li, Xiaoyong
   Zhang, Hongmei
   Lin, Ning
   Gu, Hongxia
   Wen, Jie
   Ning, Guang
   Qin, Li
   Su, Qing
TI Large mid-upper arm circumference is associated with metabolic syndrome
   in middle-aged and elderly individuals: a community-based study
SO BMC ENDOCRINE DISORDERS
LA English
DT Article
DE Metabolic syndrome; Mid-upper arm circumference; Central obesity;
   Subcutaneous fat
ID ENDOPLASMIC-RETICULUM STRESS; FATTY-ACID-METABOLISM; INSULIN-RESISTANCE;
   ADIPOSE-TISSUE; CARDIOVASCULAR-DISEASE; NECK CIRCUMFERENCE; OBESITY;
   LIPOLYSIS; LINKS; INFLAMMATION
AB Background The mid-upper arm circumference (MUAC) is a proxy for subcutaneous fat in the upper body and is a reliable screening measure for identifying individuals with abnormal regional fat distribution. The purpose of this study was to evaluate the association between MUAC and metabolic syndrome (MetS) in middle-aged and elderly individuals. Methods We measured the MUAC in a cross-sectional sample with a total of 9787 subjects aged 40 years and older. The measurement of MUAC is performed on the right arm using a non-elastic tape held midway between the acromion and the olecranon processes in duplicate, with the arm hanging loosely at the side of the body. The MetS was defined according to the Joint Statement of the International Diabetes Federation Task Force on Epidemiology and Prevention. Results MUAC was positively correlated with waist circumference (r = 0.437, P < 0.001), BMI (r = 0.334, P < 0.001), fasting insulin (r = 0.348, P < 0.001), HOMA-IR (r = 0.134, P < 0.001), triglycerides (r = 0.138, P < 0.001), SBP (r = 0.124, P < 0.001), and DBP (r = 0.123, P < 0.001), and inversely correlated with adiponectin (r = - 0.147, P < 0.001) and HDL-cholesterol (r = - 0.176, P < 0.001) after adjusting for age and gender. Compared with the lowest quartile group, the odds ratios were substantially higher for MetS (OR 1.77; 95% CI 1.51-2.09, P for trend< 0.001) in the highest MUAC quartile group after adjustment for potential cofounder. Conclusion Large mid-upper arm circumference is significantly associated with metabolic syndrome in middle-aged and elderly individuals.
C1 [Shi, Jie; Yang, Zhen; Niu, Yixin; Zhang, Weiwei; Li, Xiaoyong; Zhang, Hongmei; Lin, Ning; Qin, Li; Su, Qing] Shanghai Jiao Tong Univ, Sch Med, Dept Endocrinol, Xinhua Hosp,Chongming Branch, 25 Nanmen Rd, Shanghai 202150, Peoples R China.
   [Shi, Jie; Yang, Zhen; Niu, Yixin; Gu, Hongxia; Qin, Li; Su, Qing] Shanghai Jiao Tong Univ, Sch Med, Dept Endocrinol, Xinhua Hosp, Shanghai 200092, Peoples R China.
   [Wen, Jie] Fudan Univ, Huashan Hosp, Dept Endocrinol & Metab, Inst Endocrinol & Diabet, Shanghai 200040, Peoples R China.
   [Ning, Guang] Shanghai Jiao Tong Univ, Sch Med, Shanghai Clin Ctr Endocrine & Metab Dis,Ruijin Ho, Shanghai Inst Endocrinol & Metab,Dept Endocrine &, Shanghai 200025, Peoples R China.
C3 Shanghai Jiao Tong University; Shanghai Jiao Tong University; Fudan
   University; Shanghai Jiao Tong University
RP Yang, Z; Qin, L; Su, Q (corresponding author), Shanghai Jiao Tong Univ, Sch Med, Dept Endocrinol, Xinhua Hosp,Chongming Branch, 25 Nanmen Rd, Shanghai 202150, Peoples R China.
EM yangzhen@xinhuamed.com.cn; qinli@xinhuamed.com.cn;
   suqing@xinhuamed.com.cn
RI Martinez, Ramfis/I-7205-2019
FU National Natural Science Foundation of China [81670743, 81370953];
   Shanghai Health System Outstanding Young Talents Training Program
   [XYQ2013098]; Shanghai Health and Family Planning Commission [21740173]
FX This work was supported by the National Natural Science Foundation of
   China (81670743, 81370953), Shanghai Health System Outstanding Young
   Talents Training Program (XYQ2013098), Shanghai Health and Family
   Planning Commission (21740173). The funding body had no role in the
   design of the study and collection, analysis, and interpretation of data
   and in writing the manuscript.
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NR 39
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Z9 24
U1 0
U2 11
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1472-6823
J9 BMC ENDOCR DISORD
JI BMC Endocr. Disord.
PD JUN 3
PY 2020
VL 20
IS 1
AR 78
DI 10.1186/s12902-020-00559-8
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA LY0UW
UT WOS:000540240200001
PM 32493449
OA Green Submitted, gold, Green Published
DA 2025-06-11
ER

PT J
AU Godin, O
   Leboyer, M
   Gaman, A
   Aouizerate, B
   Berna, F
   Brunel, L
   Capdevielle, D
   Chereau, I
   Dorey, JM
   Dubertret, C
   Dubreucq, J
   Faget, C
   Gabayet, F
   Le Strat, Y
   Llorca, PM
   Misdrahi, D
   Rey, R
   Richieri, R
   Passerieux, C
   Schandrin, A
   Schuerhoff, F
   Urbach, M
   Vidalhet, P
   Girerd, N
   Fond, G
AF Godin, O.
   Leboyer, M.
   Gaman, A.
   Aouizerate, B.
   Berna, F.
   Brunel, L.
   Capdevielle, D.
   Chereau, I.
   Dorey, J. M.
   Dubertret, C.
   Dubreucq, J.
   Faget, C.
   Gabayet, F.
   Le Strat, Y.
   Llorca, P. M.
   Misdrahi, D.
   Rey, R.
   Richieri, R.
   Passerieux, C.
   Schandrin, A.
   Schuerhoff, F.
   Urbach, M.
   Vidalhet, P.
   Girerd, N.
   Fond, G.
CA Face-Sz Grp
TI Metabolic syndrome, abdominal obesity and hyperuricemia in
   schizophrenia: Results from the FACE-SZ cohort
SO SCHIZOPHRENIA RESEARCH
LA English
DT Article
DE Metabolic syndrome; Hyperuricemia; Abdominal obesity; Comorbidity;
   Schizophrenia
ID SERUM URIC-ACID; OF-RHEUMATOLOGY GUIDELINES; INDEPENDENT RISK-FACTOR;
   INDUCED WEIGHT-GAIN; MIDDLE-AGED MEN; CARDIOVASCULAR RISK;
   GENERAL-POPULATION; NATIONAL-HEALTH; ALL-CAUSE; METAANALYSIS
AB Objective: Abdominal obesity was suggested to be a better predictor than Metabolic Syndrome (MetS) for cardiovascular mortality, however this is has not been extensively studied in schizophrenia. Hyperuricemia (HU) was also suggested to be both an independent risk factor for greater somatic comorbidity and a global metabolic stress marker in patients with schizophrenia.
   The aim of this study was to estimate the prevalence of MetS, abdominal obesity and HU, to examine the association between metabolic parameters with HU in a cohort of French patients with schizophrenia or schizo-affective disorder (SZ), and to estimate the prevalence rates of treatment of cardio-vascular risk factors.
   Method: 240 SZ patients (age = 31.4 years, male gender 74.3%) were systematically included. Metabolic syndrome was defined according to the International Diabetes Federation and HU if serum uric acid level was above 360 mu mol/L.
   Results: MetS, abdominal obesity and HU were found respectively in 24.2%, 21.3% and 19.6% of patients. In terms of risk factors, multiple logistic regression showed that after taking into account the potential confounders, the risk for HU was higher in males (OR = 5.9, IC95 [1.7-21.4]) and in subjects with high waist circumference (OR=3.1, IC95 [1.1-8.3]) or hypertriglyceridemia (OR=4.9, IC95 [1.9-13]). No association with hypertension, low HDL cholesterol or high fasting glucose was observed. Only 10% of patients with hypertension received a specific treatment, 18% for high fasting glucose and 8% for dyslipidemia.
   Conclusions: The prevalence of MetS, abdominal obesity and hyperuricemia is elevated in French patients with schizophrenia, all of which are considerably under-diagnosed and undertreated. HU is strongly associated with abdominal obesity but not with psychiatric symptomatology. (C) 2015 Elsevier B.V. All rights reserved.
C1 [Godin, O.; Leboyer, M.; Gaman, A.; Aouizerate, B.; Berna, F.; Brunel, L.; Capdevielle, D.; Chereau, I.; Dorey, J. M.; Dubertret, C.; Dubreucq, J.; Faget, C.; Gabayet, F.; Le Strat, Y.; Llorca, P. M.; Misdrahi, D.; Rey, R.; Richieri, R.; Passerieux, C.; Schandrin, A.; Schuerhoff, F.; Urbach, M.; Fond, G.] Fdn FondaMental, Creteil, France.
   [Godin, O.] Univ Paris 06, Sorbonne Univ, Inst Pierre Louis Epidemiol & St Publ, UMR_S 1136, F-75013 Paris, France.
   [Godin, O.] INSERM, UMR_S 1136, Inst Pierre Louis Epidmiol & St Publ, F-75013 Paris, France.
   [Leboyer, M.; Brunel, L.; Schuerhoff, F.; Fond, G.] Univ Paris Est Creteil, Pole Psychiat & Addictol Hopitaux Univ H Mondor, INSERM,DHU Pe PSY, Eq Psychiat Genet & Psychopathol 15,U955, Creteil, France.
   [Aouizerate, B.; Misdrahi, D.] Ctr Hosp Charles Perrens, F-33076 Bordeaux, France.
   [Aouizerate, B.; Misdrahi, D.] Univ Bordeaux, Bordeaux, France.
   [Berna, F.; Vidalhet, P.] Univ Strasbourg, Hop Univ Strasbourg, INSERM, Fedarat Med Translationnelle Strasbourg,U1114, Strasbourg, France.
   [Capdevielle, D.; Schandrin, A.] Univ Montpellier I, Serv Univ Psychiat Adulte, Hop Colombiere, CHRU Montpellier,Inserm 1061, Montpellier, France.
   [Chereau, I.; Llorca, P. M.] Univ Auvergne, CMP B, CHU, Fac Med,EA 7280, F-63003 Clermont Ferrand 1, France.
   [Dorey, J. M.; Rey, R.] Univ Claude Bernard Lyon 1, Ctr Hosp Vinatier, F-69678 Bron, France.
   [Dubertret, C.; Le Strat, Y.] Univ Paris Diderot, Louis Mourier Hosp, AP HP,Dept Psychiat, Sorbonne Paris Cite,Fac Med,Inserm U894, Paris, France.
   [Dubreucq, J.; Gabayet, F.] CH Alpes Isere, Ctr Referent Rehabil Psychosociale, Grenoble, France.
   [Faget, C.; Richieri, R.] Pole Univ Psychiat, AP HM, Marseille, France.
   [Passerieux, C.; Urbach, M.] Univ Versailles St Quentin Yvelines, Serv Psychiat Adulte, Ctr Hosp Versailles, UFR Sci St Simone Veil, Versailles, France.
   [Girerd, N.] Univ Lorraine, CHU Nancy, Ctr Invest Clin 9501 & U1116,INSERM, Inst Lorrain Coeur & Vaisseaux Louis Mathieu, F-54500 Vandoeuvre Les Nancy, France.
   [Aouizerate, B.] INSERM, Neuroctr Magendie, Physiopathol Plasticite Neuronale, U862, F-33000 Bordeaux, France.
   [Misdrahi, D.] CNRS, UMR 5287, INCIA, Paris, France.
C3 Sorbonne Universite; Institut National de la Sante et de la Recherche
   Medicale (Inserm); Sorbonne Universite; Institut National de la Sante et
   de la Recherche Medicale (Inserm); Assistance Publique Hopitaux Paris
   (APHP); Universite Paris-Est-Creteil-Val-de-Marne (UPEC); Hopital
   Universitaire Henri-Mondor - APHP; Institut National de la Sante et de
   la Recherche Medicale (Inserm); Universite de Bordeaux; Universite de
   Lorraine; Institut National de la Sante et de la Recherche Medicale
   (Inserm); CHU Strasbourg; Universites de Strasbourg Etablissements
   Associes; Universite de Strasbourg; Universite de Montpellier; Institut
   National de la Sante et de la Recherche Medicale (Inserm); CHU de
   Montpellier; Universite Clermont Auvergne (UCA); CHU Clermont Ferrand;
   Universite Claude Bernard Lyon 1; Universite Paris Cite; Institut
   National de la Sante et de la Recherche Medicale (Inserm); Assistance
   Publique Hopitaux Paris (APHP); Hopital Universitaire Louis-Mourier -
   APHP; Aix-Marseille Universite; Assistance Publique-Hopitaux de
   Marseille; Centre Hospitalier de Versailles; Universite Paris Saclay;
   Institut National de la Sante et de la Recherche Medicale (Inserm);
   Universite de Lorraine; CHU de Nancy; Universite de Bordeaux; Institut
   National de la Sante et de la Recherche Medicale (Inserm); Centre
   National de la Recherche Scientifique (CNRS); CNRS - National Institute
   for Biology (INSB)
RP Fond, G (corresponding author), Hop A Chenevier, Pole Psychiat, 40 Rue Mesly, F-94010 Creteil, France.
EM guillaume.fond@gmail.com
RI GIRERD, Nicolas/D-5493-2011; Berna, Fabrice/J-2701-2019; Le Strat,
   Yann/C-9848-2013; richieri, raphaelle/E-4707-2015; Capdevielle,
   Delphine/HTO-4229-2023; Leboyer, Marion/AAW-3648-2021; Schandrin,
   Aurélie/ISV-4608-2023; JeanMichel, Dorey/KHZ-0906-2024; FOND,
   Guillaume/D-7646-2011; TESSIER, Arnaud/A-4022-2017
OI Capdevielle, Delphine/0000-0002-7146-8554; Misdrahi,
   David/0000-0003-1146-3206; dubreucq, julien/0000-0003-4079-4194;
   Aouizerate, Bruno/0000-0002-7092-7747; Berna,
   Fabrice/0000-0002-6118-0629; D'Amato, Thierry/0000-0001-8983-0315;
   LEBOYER, Marion/0000-0001-5473-3697; Girerd,
   Nicolas/0000-0002-3278-2057; FOND, Guillaume/0000-0003-3249-2030;
   DANION, Jean-Marie/0000-0002-1980-1006; RICHIERI,
   Raphaelle/0000-0002-3901-7016; REY, Romain/0000-0002-4603-3575; TESSIER,
   Arnaud/0000-0001-5758-5693
FU AP-HP (Assistance Publique des Hopitaux de Paris), Fondation Fondamental
   (RTRS Sante Mentale); Investissements d'Avenir program
   [ANR-11-IDEX-0004-02, ANR-10-COHO-10-01]; INSERM (Institut National de
   la Sante et de la Recherche Medicale)
FX This work was funded by AP-HP (Assistance Publique des Hopitaux de
   Paris), Fondation Fondamental (RTRS Sante Mentale), by the
   Investissements d'Avenir program managed by the ANR under reference
   ANR-11-IDEX-0004-02 and ANR-10-COHO-10-01, and by INSERM (Institut
   National de la Sante et de la Recherche Medicale). We express all our
   thanks to the nurses, with special thanks to Emmanuelle Abadie, and to
   the patients who were included in the present study.
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NR 46
TC 55
Z9 58
U1 0
U2 26
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0920-9964
EI 1573-2509
J9 SCHIZOPHR RES
JI Schizophr. Res.
PD OCT
PY 2015
VL 168
IS 1-2
BP 388
EP 394
DI 10.1016/j.schres.2015.07.047
PG 7
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA CS1LK
UT WOS:000361826400056
PM 26255568
DA 2025-06-11
ER

PT J
AU Bahari, H
   Zeraattalab-Motlagh, S
   Hezaveh, ZS
   Namkhah, Z
   Golafrouz, H
   Taheri, S
   Sahebkar, A
AF Bahari, Hossein
   Zeraattalab-Motlagh, Sheida
   Hezaveh, Zohreh Sajadi
   Namkhah, Zahra
   Golafrouz, Haniyeh
   Taheri, Shaghayegh
   Sahebkar, Amirhossein
TI The Effects of Sumac Consumption on Inflammatory and Oxidative Stress
   Factors: A Systematic Review of Randomized Clinical Trials
SO CURRENT PHARMACEUTICAL DESIGN
LA English
DT Review
DE Sumac; spice; Rhus coriaria; antioxidant; inflammation; trial
ID RHUS-CORIARIA-L.; GALLIC ACID; ANTIOXIDANT; EXTRACT; POWDER; LIFE
AB Background: Rhus coriaria L., commonly known as Sumac, is a plant from the Anacardiaceae family that is known for its high phytochemical content. These phytochemicals have the potential to effectively manage inflammation and oxidative stress. To explore the existing evidence on the impact of Sumac consumption on inflammation and oxidative stress, we conducted a systematic review of randomized controlled trials. Methods: We conducted a comprehensive search of Medline/PubMed, Scopus, and Web of Science from inception to August 2023 to identify relevant studies examining the effects of Sumac on biomarkers of inflammation and oxidative stress. The selected studies were assessed for risk of bias using the Cochrane tool. Results: A total of seven trials were included in this review. Among these trials, three focused on diabetes patients, while the remaining four involved individuals with fatty liver, overweight individuals with depression, and those with polycystic ovary or metabolic syndrome. Five studies reported the effects of Sumac on oxidative stress, with four of them demonstrating a significant reduction in malondialdehyde (MDA) levels and an increase in total antioxidant capacity (TAC) and paraoxonase 1 (PON1). Regarding inflammation, one study reported no significant difference in tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) levels between the intervention and control groups. The results for high-sensitivity C-reactive protein levels, reported in five trials, were inconsistent. Conclusion: Sumac consumption over time may positively affect oxidative stress, although short-term use shows minimal impact. While one study found no significant effect on IL-6 and TNF-alpha, hs-CRP levels could decrease or remain unchanged. Further meta-analyses are needed to fully understand Sumac's potential benefits in managing metabolic diseases.
C1 [Bahari, Hossein] Mashhad Univ Med Sci, Clin Res Inst, Transplant Res Ctr, Mashhad, Iran.
   [Bahari, Hossein; Namkhah, Zahra] Mashhad Univ Med Sci, Fac Med, Dept Nutr, Mashhad, Iran.
   [Zeraattalab-Motlagh, Sheida] Univ Houston, Dept Hlth & Human Performance, Houston, TX USA.
   [Zeraattalab-Motlagh, Sheida] Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Community Nutr, Tehran, Iran.
   [Hezaveh, Zohreh Sajadi] Univ Sydney, Fac Med & Hlth, Dept Hlth Sci, Sydney, NSW, Australia.
   [Namkhah, Zahra] Mashhad Univ Med Sci, Student Res Comm, Mashhad, Iran.
   [Golafrouz, Haniyeh] Islamic Azad Univ, Dept Med Sci & Technol, Sci & Res Branch, Tehran, Iran.
   [Taheri, Shaghayegh] Birjand Univ Med Sci, Sch Med, Dept Clin Biochem, Birjand, Iran.
   [Sahebkar, Amirhossein] Saveetha Univ, Saveetha Inst Med & Tech Sci, Saveetha Med Coll & Hosp, Ctr Global Hlth Res, Chennai, India.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Biotechnol Res Ctr, Mashhad, Iran.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Appl Biomed Res Ctr, Mashhad, Iran.
C3 Mashhad University of Medical Sciences; Mashhad University of Medical
   Sciences; University of Houston System; University of Houston; Tehran
   University of Medical Sciences; University of Sydney; Mashhad University
   of Medical Sciences; Islamic Azad University; Birjand University of
   Medical Sciences; Saveetha Institute of Medical & Technical Science;
   Saveetha Medical College & Hospital; Mashhad University of Medical
   Sciences; Mashhad University of Medical Sciences
RP Sahebkar, A (corresponding author), Mashhad Univ Med Sci, Pharmaceut Technol Inst, Appl Biomed Res Ctr, Mashhad, Iran.
EM amir_saheb2000@yahoo.com
RI Sahebkar, Amirhossein/B-5124-2018; bahari, hossein/AEP-7036-2022;
   Sajadi'Hezaveh, Zohreh/LEM-1778-2024
OI Bahari, Hossein/0000-0002-3787-2713
FU Transplant Research Center, Mashhad University of Medical Sciences
FX We would like to thank the Transplant Research Center, Mashhad
   University of Medical Sciences, for supporting this manuscript.
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NR 64
TC 0
Z9 0
U1 2
U2 3
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1381-6128
EI 1873-4286
J9 CURR PHARM DESIGN
JI Curr. Pharm. Design
PY 2024
VL 30
IS 27
BP 2142
EP 2151
DI 10.2174/0113816128305609240529114411
EA JUN 2024
PG 10
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA D5J8P
UT WOS:001251794300001
PM 38920072
DA 2025-06-11
ER

PT J
AU Morrato, EH
AF Morrato, Elaine H.
TI An update on lipid profile screening in second-generation antipsychotic
   users in the USA
SO CLINICAL LIPIDOLOGY
LA English
DT Review
DE antipsychotics; dyslipidemia; lipids; risk management; screening
ID CATIE SCHIZOPHRENIA TRIAL; INDUCED WEIGHT-GAIN; METABOLIC RISK;
   MENTAL-ILLNESS; DOUBLE-BLIND; 1ST-EPISODE SCHIZOPHRENIA; CARDIOMETABOLIC
   RISK; CHILDREN; CARE; DYSLIPIDEMIA
AB Second-generation antipsychotics (SGAs) are commonly prescribed for the treatment of schizophrenia, bipolar disorder, major depression and other behavioral and neuropsychiatric conditions. Treatment with SGA medications can induce adverse metabolic side effects, including clinically significant weight gain, hyperglycemia/diabetes mellitus and dyslipidemia. Product labeling and medical guidelines recommend that patients be routinely monitored for weight gain and serum glucose and lipid abnormalities. This review provides an update on lipid profile screening for patients taking SGA medications. The review focuses primarily on evidence from the USA, including data on risk awareness, physician intent to screen patients and population-based estimates of testing rates. Patient, provider and system barriers to lipid screening are also discussed. Quality improvement examples are provided to illustrate the progress being made in improving metabolic screening of SGA users.
C1 Univ Colorado, Aurora, CO USA.
C3 University of Colorado System; University of Colorado Anschutz Medical
   Campus
RP Morrato, EH (corresponding author), Univ Colorado, Anschutz Med Campus,POB 6508,Mailstop F443, Aurora, CO USA.
EM elaine.morrato@ucdenver.edu
FU Agency for Healthcare Research and Quality [K12HS019464]; Janssen
   Scientific Affairs, LLC; MedScape
FX This project was supported by grant number K12HS019464 from the Agency
   for Healthcare Research and Quality. The content is solely the
   responsibility of the author and does not necessarily represent the
   official views of the Agency for Healthcare Research and Quality. The
   author has received research funding from Janssen Scientific Affairs,
   LLC and MedScape. The author has no other relevant affiliations or
   financial involvement with any organization or entity with a financial
   interest in or financial conflict with the subject matter or materials
   discussed in the manuscript apart from those disclosed.
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NR 98
TC 2
Z9 2
U1 0
U2 12
PU FUTURE MEDICINE LTD
PI LONDON
PA UNITEC HOUSE, 3RD FLOOR, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON, N3
   1QB, ENGLAND
SN 1758-4299
EI 1758-4302
J9 CLIN LIPIDOL
JI Clin. Lipidol.
PD OCT
PY 2012
VL 7
IS 5
BP 509
EP 523
DI 10.2217/CLP.12.51
PG 15
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 028IS
UT WOS:000310416600009
DA 2025-06-11
ER

PT J
AU Tunc-Ata, M
   Altintas, F
   Senol, H
   Nizamoglu, E
   Kucukatay, V
AF Tunc-Ata, Melek
   Altintas, Fatih
   Senol, Hande
   Nizamoglu, Erol
   Kucukatay, Vural
TI Ileal interposition improves metabolic syndrome parameters in a rat
   model of metabolic syndrome induced by monosodium glutamate
SO LIFE SCIENCES
LA English
DT Article
DE Metabolic syndrome; Ileal interposition; Glucagon like peptide-1;
   Glucagon like peptide-1 receptor; Monosodium glutamate
ID Y GASTRIC BYPASS; INSULIN-RESISTANCE; GLUCOSE-TOLERANCE; OXIDATIVE
   STRESS; OBESITY; GROWTH; TRANSPOSITION; SURGERY; ENERGY; MICE
AB Aims: Metabolic syndrome (MetS) is a cluster of metabolic abnormalities. Anatomically restructuring of the gastrointestinal system has recently been an important subject of research in the treatment of MetS and closely related diseases. The aim of this study is to ensure the remission of parameters that define MetS by ileal interposition (IT) and to examine the effect of IT on plasma total GLP-1 and pancreatic GLP-1R expression.
   Main methods: To induce MetS, newborn male Wistar albino rats were given MSG (4 g/mg) on days 0, 2, 4, 6, 8, and 10. The control group was injected with saline. In the 5th month, IT or sham surgery was performed on the MetS rats. The lipid levels, abdominal obesity, insulin level, OGTT, Lee index, HOMA-IR, plasma GLP-1 and pancreas GLP-1R expression were evaluated 2 months after surgery.
   Key findings: The results showed that IT significantly improved hyperinsulinemia (p = 0.013) and lipid profile (TG p = 0.0001; TCHOL p = 0.018; HDL p = 0.001). Furthermore, it normalized the Lee index (p = 0.006) and insulin resistance. The IT did not affect the secretion of the GLP-1, but the expression levels of pancreas GLP-1R were increased (p = 0.006).
   Significance: IT surgery corrected the MetS parameters in this rat model. The healing effects of IT surgery could be caused by mechanisms in the target tissues of insulin. The decrease in pancreatic GLP-1R levels in the MetS groups might be a compensatory response to the harmful effects of hyperinsulinemia in these groups. These results show that IT can be useful in the treatment of MetS.
C1 [Tunc-Ata, Melek; Altintas, Fatih; Kucukatay, Vural] Pamukkale Univ, Dept Physiol, Med Fac, TR-20160 Denizli, Turkey.
   [Senol, Hande] Pamukkale Univ, Dept Biostat, Med Fac, TR-20160 Denizli, Turkey.
   [Nizamoglu, Erol] Akdeniz Univ, Dept Physiol, Med Fac, TR-20160 Antalya, Turkey.
C3 Pamukkale University; Pamukkale University; Akdeniz University
RP Kucukatay, V (corresponding author), Pamukkale Univ, Dept Physiol, Med Fac, TR-20160 Denizli, Turkey.
EM melekt@pau.edu.tr; faltintas@pau.edu.tr; hsenol@pau.edu.tr;
   enizam@akdeniz.edu.tr; vkucukatay@pau.edu.tr
RI Kucukatay, Vural/ABI-6427-2020; Altintas, Fatih/ABF-5161-2021
OI Altintas, Fatih/0000-0001-8779-0110
FU Pamukkale University [2017SABE016]
FX This study is supported by funding from the Pamukkale University
   (project number 2017SABE016).
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NR 42
TC 5
Z9 5
U1 1
U2 8
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0024-3205
EI 1879-0631
J9 LIFE SCI
JI Life Sci.
PD FEB 1
PY 2021
VL 266
AR 118846
DI 10.1016/j.lfs.2020.118846
PG 9
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA PV5TE
UT WOS:000610049400008
PM 33309719
DA 2025-06-11
ER

PT J
AU Kallio, P
   Kolehmainen, M
   Laaksonen, DE
   Kekäläinen, J
   Salopuro, T
   Sivenius, K
   Pulkkinen, L
   Mykkänen, HM
   Niskanen, L
   Uusitupa, M
   Poutanen, KS
AF Kallio, Petteri
   Kolehmainen, Marjukka
   Laaksonen, David E.
   Kekalainen, Jani
   Salopuro, Titta
   Sivenius, Katariina
   Pulkkinen, Leena
   Mykkanen, Hannu M.
   Niskanen, Leo
   Uusitupa, Matti
   Poutanen, Kaisa S.
TI Dietary carbohydrate modification induces alterations in gene expression
   in abdominal subcutaneous adipose tissue in persons with the metabolic
   syndrome:: the FUNGENUT Study
SO AMERICAN JOURNAL OF CLINICAL NUTRITION
LA English
DT Article
DE gene-nutrient interactions; metabolic syndrome; insulin resistance;
   microarray; adipose tissue; diet intervention; insulinernic response;
   rye; oat; wheat
ID POSTPRANDIAL INSULIN-RESPONSE; IMPAIRED GLUCOSE-TOLERANCE; FAT-CELLS;
   GLYCEMIC INDEX; RYE BREAD; SENSITIVITY; SECRETION; FIBER; INFLAMMATION;
   RESISTANCE
AB Background: Diets rich in whole-grain cereals and foods with a low glycemic index may protect against type 2 diabetes, but the underlying molecular mechanisms are unknown.
   Objective: The main objective was to test whether 2 different carbohydrate modifications-a rye-pasta diet characterized by a low postprandial insulin response and an oat-wheat-potato diet characterized by a high postprandial insulin response-affect gene expression in subcutaneous adipose tissue (SAT) in persons with the metabolic syndrome.
   Design: We assessed the effect of carbohydrate modification on SAT gene expression in 47 subjects [24 men and 23 women with a mean (+/- SD) age of 55 +/- 6 y] with the features of the metabolic syndrome in a parallel study design. The subjects had a mean ( SD) body mass index (kg/m(2)) of 32.1 +/- 3.8 and a 2-h plasma glucose concentration of 8.0 +/- 2.3 mmol/L. Adipose tissue biopsies were performed, and oral-glucose-tolerance tests and other biochemical measurements were conducted before and after the intervention. Results: We detected 71 down-regulated genes in the rye-pasta group, including genes linked to insulin signaling and apoptosis. In contrast, the 12-wk oat-wheat-potato diet up-regulated 62 genes related to stress, cytokine-chemokine-mediated immunity, and the interleukin pathway. The insulinogenic index improved after the rye-pasta diet (P = 0.004) but not after the oat-wheat-potato diet. Body weight was unchanged in both groups.
   Conclusions: Dietary carbohydrate modification with rye and pasta or oat, wheat, and potato differentially modulates the gene expression profile in abdominal subcutaneous adipose tissue, even in the absence of weight loss.
C1 Univ Kuopio, Dept Clin Nutr, Food & Hlth Res Ctr, FIN-70211 Kuopio, Finland.
   Univ Kuopio, Dept Med, FIN-70211 Kuopio, Finland.
   Univ Kuopio, Dept Comp Sci, FIN-70211 Kuopio, Finland.
   VTT, Espoo, Finland.
C3 University of Eastern Finland; University of Eastern Finland; University
   of Eastern Finland; VTT Technical Research Center Finland
RP Kolehmainen, M (corresponding author), Univ Kuopio, Dept Clin Nutr, Food & Hlth Res Ctr, FIN-70211 Kuopio, Finland.
EM marjukka.kolehmainen@uku.fi
RI Uusitupa, Matti/AAX-4929-2020; Kolehmainen, Marjukka/JFS-1563-2023
OI Kolehmainen, Marjukka/0000-0002-3770-2538
CR Bachoo RM, 2004, P NATL ACAD SCI USA, V101, P8384, DOI 10.1073/pnas.0402140101
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NR 46
TC 102
Z9 117
U1 0
U2 17
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0002-9165
EI 1938-3207
J9 AM J CLIN NUTR
JI Am. J. Clin. Nutr.
PD MAY
PY 2007
VL 85
IS 5
BP 1417
EP 1427
DI 10.1093/ajcn/85.5.1417
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 168GN
UT WOS:000246511400033
PM 17490981
OA Bronze
DA 2025-06-11
ER

PT J
AU Wennersberg, MH
   Smedman, A
   Turpeinen, AM
   Retterstol, K
   Tengblad, S
   Lipre, E
   Aro, A
   Mutanen, P
   Seljeflot, I
   Basu, S
   Pedersen, JI
   Mutanen, M
   Vessby, B
AF Wennersberg, Marianne Hauge
   Smedman, Annika
   Turpeinen, Anu M.
   Retterstol, Kjetil
   Tengblad, Siv
   Lipre, Endla
   Aro, Antti
   Mutanen, Pertti
   Seljeflot, Ingebjorg
   Basu, Samar
   Pedersen, Jan I.
   Mutanen, Marja
   Vessby, Bengt
TI Dairy products and metabolic effects in overweight men and women:
   results from a 6-mo intervention study
SO AMERICAN JOURNAL OF CLINICAL NUTRITION
LA English
DT Article
ID CORONARY-HEART-DISEASE; BLOOD-PRESSURE; DIETARY CALCIUM; SATURATED FAT;
   NUTRIENT INTAKE; SERUM-LIPIDS; RISK-FACTORS; BODY-WEIGHT; MILK-FAT;
   CHOLESTEROL
AB Background: Some epidemiologic studies have suggested inverse relations between intake of dairy products and components of the metabolic syndrome.
   Objective: The objective was to investigate the effects of an increased intake of dairy products in persons with a habitually low intake on body composition and factors related to the metabolic syndrome.
   Design: Middle-aged overweight subjects (n = 121) with traits of the metabolic syndrome were recruited in Finland, Norway, and Sweden and randomly assigned into milk or control groups. The milk group was instructed to consume 3-5 portions of dairy products daily. The control group maintained their habitual diet. Clinical investigations were conducted on admission and after 6 mo.
   Results: There were no significant differences between changes in body weight or body composition, blood pressure, markers of inflammation, endothelial function, adiponectin, or oxidative stress in the milk and the control groups. There was a modest unfavorable increase in serum cholesterol concentrations in the milk group (P = 0.043). Among participants with a low calcium intake at baseline (<700 mg/d), there was a significant treatment effect for waist circumference (P = 0.003) and sagittal abdominal diameter (P = 0.034). When the sexes were analyzed separately, leptin increased (P = 0.045) and vascular cell adhesion molecule-1 decreased (P = 0.001) in women in the milk group.
   Conclusions: This study gives no clear support to the hypothesis that a moderately increased intake of dairy products beneficially affects aspects of the metabolic syndrome. The apparently positive effects on waist circumference and sagittal abdominal diameter in subjects with a low calcium intake suggest a possible threshold in relation to effects on body composition. Am J Clin Nutr 2009;90:960-8.
C1 [Smedman, Annika; Tengblad, Siv; Basu, Samar; Vessby, Bengt] Uppsala Univ, Dept Publ Hlth & Caring Sci, S-75125 Uppsala, Sweden.
   [Turpeinen, Anu M.; Lipre, Endla; Mutanen, Marja] Univ Helsinki, Div Nutr, Dept Appl Chem & Microbiol, Helsinki, Finland.
   [Aro, Antti] Natl Inst Hlth & Welf, Helsinki, Finland.
   [Wennersberg, Marianne Hauge; Pedersen, Jan I.] Univ Oslo, Dept Nutr, Oslo, Norway.
   [Wennersberg, Marianne Hauge; Retterstol, Kjetil] Oslo Univ Hosp, Dept Med, Rikshosp, Lipid Clin, Oslo, Norway.
   [Seljeflot, Ingebjorg] Ullevaal Univ Hosp, Dept Cardiol, Oslo, Norway.
C3 Uppsala University; University of Helsinki; Finland National Institute
   for Health & Welfare; University of Oslo; University of Oslo; National
   Hospital Norway; University of Oslo
RP Vessby, B (corresponding author), Uppsala Univ, Dept Publ Hlth & Caring Sci, POB 609, S-75125 Uppsala, Sweden.
EM bengt.vessby@pubcare.uu.se
FU Finnish Ministry of Agriculture and Forestry; National Research Council
   of Norway; Information Office for Milk Products, Norway; Swedish
   Farmer's Foundation for Agricultural Research; Swedish Dairy Association
FX Supported by the Finnish Ministry of Agriculture and Forestry; the
   National Research Council of Norway; the Information Office for Milk
   Products, Norway; the Swedish Farmer's Foundation for Agricultural
   Research; and the Swedish Dairy Association.
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NR 50
TC 131
Z9 147
U1 0
U2 12
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0002-9165
EI 1938-3207
J9 AM J CLIN NUTR
JI Am. J. Clin. Nutr.
PD OCT 1
PY 2009
VL 90
IS 4
BP 960
EP 968
DI 10.3945/ajcn.2009.27664
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 496GC
UT WOS:000269956700011
PM 19710195
DA 2025-06-11
ER

PT J
AU Conti, FF
   Brito, JD
   Bernardes, N
   Dias, DD
   Malfitano, C
   Morris, M
   Llesuy, SF
   Irigoyen, MC
   De Angelis, K
AF Conti, Filipe Fernandes
   Brito, Janaina de Oliveira
   Bernardes, Nathalia
   Dias, Danielle da Silva
   Malfitano, Christiane
   Morris, Mariana
   Francisca Llesuy, Susana
   Irigoyen, Maria-Claudia
   De Angelis, Katia
TI Positive effect of combined exercise training in a model of metabolic
   syndrome and menopause: autonomic, inflammatory, and oxidative stress
   evaluations
SO AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY, INTEGRATIVE AND COMPARATIVE
   PHYSIOLOGY
LA English
DT Article
DE exercise training; menopause; metabolic syndrome; blood pressure
   variability; inflammation; oxidative stress
ID RESISTANCE EXERCISE; BLOOD-PRESSURE; CARDIOVASCULAR-DISEASE;
   CLINICAL-CARDIOLOGY; INSULIN-RESISTANCE; BENEFITS; INDIVIDUALS;
   DYSFUNCTION; IMPROVEMENT; COUNCIL
AB It is now well established that after menopause cardiometabolic disorders become more common. Recently, resistance exercise has been recommended as a complement to aerobic (combined training, CT) for the treatment of cardiometabolic diseases. The aim of this study was to evaluate the effects of CT in hypertensive ovariectomized rats undergoing fructose overload in blood pressure variability (BPV), inflammation, and oxidative stress parameters. Female rats were divided into the following groups (n = 8/group): sedentary normotensive Wistar rats (C), and sedentary (FHO) or trained (FHOT) ovariectomized spontaneously hypertensive rats undergoing and fructose overload. CT was performed on a treadmill and ladder adapted to rats in alternate days (8 wk; 40-60% maximal capacity). Arterial pressure (AP) was directly measured. Oxidative stress and inflammation were measured on cardiac and renal tissues. The association of risk factors (hypertension + ovariectomy + fructose) promoted increase in insulin resistance, mean AP (FHO: 174 +/- 4 vs. C: 108 +/- 1 mmHg), heart rate (FHO: 403 +/- 12 vs. C: 352 +/- 11 beats/min), BPV, cardiac inflammation (tumor necrosis factor-alpha-FHO: 65.8 +/- 9.9 vs. C: 23.3 +/- 4.3 pg/mg protein), and oxidative stress cardiac and renal tissues. However, CT was able to reduce mean AP (FHOT: 158 +/- 4 mmHg), heart rate (FHOT: 303 +/- 5 beats/min), insulin resistance, and sympathetic modulation. Moreover, the trained rats presented increased nitric oxide bioavailability, reduced tumor necrosis factor-alpha (FHOT: 33.1 +/- 4.9 pg/mg protein), increased IL-10 in cardiac tissue and reduced lipoperoxidation, and increased antioxidant defenses in cardiac and renal tissues. In conclusion, the association of risk factors promoted an additional impairment in metabolic, cardiovascular, autonomic, inflammatory, and oxidative stress parameters and combined exercise training was able to attenuate these dysfunctions.
C1 [Conti, Filipe Fernandes; Brito, Janaina de Oliveira; Bernardes, Nathalia; Dias, Danielle da Silva; Malfitano, Christiane; De Angelis, Katia] Univ Nove de Julho UNINOVE, Lab Translat Physiol, Sao Paulo, Brazil.
   [Bernardes, Nathalia; Irigoyen, Maria-Claudia] Univ Sao Paulo, Sch Med, Heart Inst InCor, Hypertens Unit, Sao Paulo, Brazil.
   [Morris, Mariana] Nova SE Univ, Inst Neuroimmune Med, Ft Lauderdale, FL 33314 USA.
   [Francisca Llesuy, Susana] Univ Buenos Aires, Buenos Aires, DF, Argentina.
C3 Universidade Nove de Julho; Universidade de Sao Paulo; Nova Southeastern
   University; University of Buenos Aires
RP De Angelis, K (corresponding author), Univ Nove de Julho, Lab Translat Physiol, Rua Vergueiro,235-249 Liberdade, Sao Paulo, SP, Brazil.
EM prof.kangelis@uninove.br
RI Conti, Filipe/C-3060-2013; da Silva Dias, Danielle/AAN-7618-2020;
   Malfitano, Christiane/I-2701-2013; Bernardes, Nathalia/L-7460-2015;
   Irigoyen, maria Claudia/N-6880-2014; DE ANGELIS, KATIA/I-6098-2016
OI Francisca Llesuy, Susana/0000-0001-6818-051X; Irigoyen, maria
   Claudia/0000-0003-2097-3662; DE ANGELIS, KATIA/0000-0002-3640-9049
FU Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES);
   Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
   [479766/2011-8]; Fundacao de Amparo a Pesquisa do Estado de Sao Paulo
   [2012/20141-5, 2011/15828-9, 2010/171884]; CAPES
   [PVE-88881.062178/2014-01]; CNPq
FX This study was supported by Coordenacao de Aperfeicoamento de Pessoal de
   Nivel Superior (CAPES), Conselho Nacional de Desenvolvimento Cientifico
   e Tecnologico (CNPq, 479766/2011-8), and Fundacao de Amparo a Pesquisa
   do Estado de Sao Paulo (2012/20141-5; 2011/15828-9; 2010/171884); CAPES
   (PVE-88881.062178/2014-01). Maria-Claudia Irigoyen and Katia De Angelis
   are recipients of CNPq Fellowship.
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NR 51
TC 49
Z9 56
U1 0
U2 10
PU AMER PHYSIOLOGICAL SOC
PI Rockville
PA 6120 Executive Blvd, Suite 600, Rockville, MD, UNITED STATES
SN 0363-6119
EI 1522-1490
J9 AM J PHYSIOL-REG I
JI Am. J. Physiol.-Regul. Integr. Comp. Physiol.
PD DEC 15
PY 2015
VL 309
IS 12
BP R1532
EP R1539
DI 10.1152/ajpregu.00076.2015
PG 8
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA CZ7PY
UT WOS:000367293000008
PM 26423710
OA Green Published
DA 2025-06-11
ER

PT J
AU Solini, A
   Menini, S
   Rossi, C
   Ricci, C
   Santini, E
   Fantauzzi, CB
   Iacobini, C
   Pugliese, G
AF Solini, Anna
   Menini, Stefano
   Rossi, Chiara
   Ricci, Carlo
   Santini, Eleonora
   Fantauzzi, Claudia Blasetti
   Iacobini, Carla
   Pugliese, Giuseppe
TI The purinergic 2X7 receptor participates in renal
   inflammation and injury induced by high-fat diet: possible role of NLRP3
   inflammasome activation
SO JOURNAL OF PATHOLOGY
LA English
DT Article
DE renal disease; metabolic syndrome; type 2 diabetes; P2X(7) receptor;
   NLRP3
ID NF-KAPPA-B; METABOLIC SYNDROME; KIDNEY-DISEASE; P2X RECEPTORS;
   INSULIN-RESISTANCE; LIPID-METABOLISM; MESANGIAL CELLS; ADIPOSE-TISSUE;
   OBESE MICE; GLOMERULOSCLEROSIS
AB Renal disease associated with type 2 diabetes and the metabolic syndrome is characterized by a distinct inflammatory phenotype. The purinergic 2X(7) receptor (P2X(7)R) and the nucleotide-binding and oligomerization domain-like receptor containing a pyrin domain 3 (NLRP3) inflammasome have been separately shown to play a role in two models of non-metabolic chronic kidney disease. Moreover, the NLRP3 inflammasome has been implicated in chronic low-grade sterile inflammation characterizing metabolic disorders, though the mechanism(s) involved in inflammasome activation under these conditions are still unknown. We investigated the role of P2X(7)R (through activation of the NLRP3 inflammasome) in renal inflammation and injury induced by a high-fat diet, an established model of the metabolic syndrome. On a high-fat diet, mice lacking P2X(7)R developed attenuated renal functional and structural alterations as well as reduced inflammation, fibrosis, and oxidative/carbonyl stress, as compared with wild-type animals, in the absence of significant differences in metabolic parameters. This was associated with blunted up-regulation of the NLRP3 inflammasome components NLRP3, apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC), pro-caspase 1, pro-interleukin (IL)-1, and pro-IL-18, as well as reduced inflammasome activation, as evidenced by decreased formation of mature caspase 1, whereas mature IL-1 and IL-18 were not detected. Up-regulated expression of NLRP3 and pro-caspase 1, post-translational processing of pro-caspase-1, and release of IL-18 in response to lipopolysaccharide+2(3)-O-(4-benzoylbenzoyl)ATP were attenuated by P2X(7)R silencing in cultured mouse podocytes. Protein and mRNA expression of P2X(7)R, NLRP3, and ASC were also increased in kidneys from subjects with type 2 diabetes and the metabolic syndrome, showing histologically documented renal disease. These data provide evidence of a major role for the purinergic system, at least in part through activation of the NLRP3 inflammasome, in the process driving metabolic' renal inflammation and injury and identify P2X(7)R and NLRP3 as novel therapeutic targets. Copyright (c) 2013 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
C1 [Solini, Anna; Rossi, Chiara; Santini, Eleonora] Univ Pisa, Dept Clin & Expt Med, I-56100 Pisa, Italy.
   [Menini, Stefano; Ricci, Carlo; Fantauzzi, Claudia Blasetti; Iacobini, Carla; Pugliese, Giuseppe] Univ Roma La Sapienza, Dept Clin & Mol Med, Rome, Italy.
C3 University of Pisa; Sapienza University Rome
RP Solini, A (corresponding author), Univ Pisa, Dept Clin & Expt Med, Via Roma 67, I-56100 Pisa, Italy.
EM anna.solini@med.unipi.it
RI Rossi, Chiara/AAI-2306-2020; Pugliese, Giuseppe/G-8776-2012; Solini,
   Anna/K-4666-2016; Menini, Stefano/G-1130-2010
OI Pugliese, Giuseppe/0000-0003-1574-0397; ROSSI,
   CHIARA/0000-0002-5724-268X; Solini, Anna/0000-0002-7855-8253; Menini,
   Stefano/0000-0001-7328-2385
FU 'La Sapienza' University; Diabetes, Endocrinology and Metabolism
   Foundation, Rome, Italy; Research Foundation of the Italian Society of
   Diabetology (Fo.Ri.SID)
FX This work was supported by grants from 'La Sapienza' University and the
   Diabetes, Endocrinology and Metabolism Foundation, Rome, Italy. Chiara
   Rossi was the recipient of a fellowship from the Research Foundation of
   the Italian Society of Diabetology (Fo.Ri.SID) for this research.
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NR 51
TC 106
Z9 113
U1 0
U2 24
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-3417
EI 1096-9896
J9 J PATHOL
JI J. Pathol.
PD NOV
PY 2013
VL 231
IS 3
BP 342
EP 353
DI 10.1002/path.4237
PG 12
WC Oncology; Pathology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Pathology
GA 232FG
UT WOS:000325476500007
PM 23843215
DA 2025-06-11
ER

PT J
AU Molokwu, JC
   Penaranda, E
   Lopez, DS
   Dwivedi, A
   Dodoo, C
   Shokar, N
AF Molokwu, Jennifer C.
   Penaranda, Eribeth
   Lopez, David S.
   Dwivedi, Alok
   Dodoo, Christopher
   Shokar, Navkiran
TI Association of Metabolic Syndrome and Human Papillomavirus Infection in
   Men and Women Residing in the United States
SO CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
LA English
DT Article
ID RISK-FACTORS; CERVICAL-CANCER; PREVALENCE; COMPONENTS; CYTOKINES; HPV
AB Background: An estimated 33% of adults in the United States have metabolic syndrome (MetS), which has been associated with an increased risk for various cancer types. Theories of synergism among components of MetS that increase cancer risk via chronic inflammation and oxidative stress have been proposed. We hypothesize that men and women with MetS may have compromised immunological response resulting in increased risk for persistent human papillomavirus (HPV) infection. The goal of this study is to determine the association of MetS with HPV types 6, 11, 16, and 18 and to explore variation of these associations by gender using data from a national survey.
   Methods: We conducted a retrospective cross-sectional study using data from the National Health and Nutrition Examination Survey.
   Results: Thirty-two percent of the population sampled met the criteria for MetS (16% men and 33% women). Nineteen percent tested positive for HPV (6, 11, 16, and 18). Prevalence of HPV infection was estimated at 13% for men and 30% for females. MetS was found to be significantly associated with increased risk of HPV6, 11, 16, or 18 in the entire cohort [RR = 1.24; 95% confidence interval (CI), 1.03-1.48] and in females (RR = 1.26; 95% CI, 1.02-1.56). Although the adjusted risk of HPV+ve status was found to be 21% higher in men with MetS compared with those without, this difference did not attain statistical significance.
   Conclusions: We observed a significant association between metabolic syndrome and HPV sero-positivity among the overall population and among females. Although not significant, a similar effect was noted in men. Further prospective studies are needed to better understand this relationship.
   Impact: To the best of our knowledge, this is the first study evaluating the impact of metabolic syndrome on HPV positivity in both males and females. (C) 2017 AACR.
C1 [Molokwu, Jennifer C.; Penaranda, Eribeth; Shokar, Navkiran] Texas Tech Univ, Hlth Sci Ctr El Paso, Dept Family & Community Med, 9849 Kenworthy St, El Paso, TX 79924 USA.
   [Lopez, David S.] Univ Texas Houston, Sch Publ Hlth, Dept Epidemiol Human Genet & Environm Sci, Houston, TX USA.
   [Dwivedi, Alok; Dodoo, Christopher] Texas Tech Univ, Hlth Sci Ctr El Paso, Grad Sch Biomed Sci, Dept Biostat & Epidemiol, 9849 Kenworthy St, El Paso, TX 79924 USA.
C3 Texas Tech University System; Texas Tech University; Texas Tech
   University Health Sciences Center El Paso; University of Texas System;
   University of Texas Health Science Center Houston; University of Texas
   School Public Health; Texas Tech University System; Texas Tech
   University; Texas Tech University Health Sciences Center El Paso
RP Molokwu, JC (corresponding author), Texas Tech Univ, Hlth Sci Ctr El Paso, 9849 Kenworthy St, El Paso, TX 79924 USA.
EM jennifer.molokwu@ttuhsc.edu
RI Dodoo, Christpher/AAE-9313-2019; Molokwu, Jennifer/J-1317-2019
OI Molokwu, Jennifer/0000-0001-7846-8189; Shokar,
   Navkiran/0000-0002-8514-9132; Lopez, David S./0000-0002-2321-0372;
   Dodoo, Christopher/0000-0001-6269-1757
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NR 41
TC 18
Z9 18
U1 0
U2 2
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 1055-9965
EI 1538-7755
J9 CANCER EPIDEM BIOMAR
JI Cancer Epidemiol. Biomarkers Prev.
PD AUG
PY 2017
VL 26
IS 8
BP 1321
EP 1327
DI 10.1158/1055-9965.EPI-17-0129
PG 7
WC Oncology; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Public, Environmental & Occupational Health
GA FI8BY
UT WOS:000412226500019
PM 28483969
DA 2025-06-11
ER

PT J
AU Wu, KLH
   Hung, CY
   Chan, JYH
   Wu, CW
AF Wu, Kay L. H.
   Hung, Chun-Ying
   Chan, Julie Y. H.
   Wu, Chih-Wei
TI An increase in adenosine-5′-triphosphate (ATP) content in rostral
   ventrolateral medulla is engaged in the high fructose diet-induced
   hypertension
SO JOURNAL OF BIOMEDICAL SCIENCE
LA English
DT Article
DE Adenosine-5 '-triphosphate; Metabolic syndrome; Fructose; Fructolysis;
   Glucose transporter; Ketohexokinase; Rostral ventrolateral medulla;
   Hypertension
ID INDUCED METABOLIC SYNDROME; SYMPATHETIC-NERVE ACTIVITY; OXIDATIVE
   STRESS; SWEETENED BEVERAGES; ARTERIAL-PRESSURE; SUPEROXIDE ANION; P2
   RECEPTORS; GLUCOSE; OBESITY; RATS
AB Background: The increase in fructose ingestion has been linked to overdrive of sympathetic activity and hypertension associated with the metabolic syndrome. The premotor neurons for generation of sympathetic vasomotor activity reside in the rostral ventrolateral medulla (RVLM). Activation of RVLM results in sympathoexcitation and hypertension. Neurons in the central nervous system are able to utilize fructose as a carbon source of ATP production. We examined in this study whether fructose affects ATP content in RVLM and its significance in the increase in central sympathetic outflow and hypertension induced by the high fructose diet (HFD).
   Results: In normotensive rats fed with high fructose diet (HFD) for 12 weeks, there was a significant increase in tissue ATP content in RVLM, accompanied by the increases in the sympathetic vasomotor activity and blood pressure. These changes were blunted by intracisternal infusion of an ATP synthase inhibitor, oligomycin, to the HFD-fed animals. In the catecholaminergic-containing N2a cells, fructose dose-dependently upregulated the expressions of glucose transporter 2 and 5 (GluT2, 5) and the rate-limiting enzyme of fructolysis, ketohexokinase (KHK), leading to the increases in pyruvate and ATP production, as well as the release of the neurotransmitter, dopamine. These cellular events were significantly prevented after the gene knocking down by lentiviral transfection of small hairpin RNA against KHK.
   Conclusion: These results suggest that increases in ATP content in RVLM may be engaged in the augmented sympathetic vasomotor activity and hypertension associated with the metabolic syndrome induced by the HFD. At cellular level, the increase in pyruvate levels via fructolysis is involved in the fructose-induced ATP production and the release of neurotransmitter.
C1 [Wu, Kay L. H.; Hung, Chun-Ying; Chan, Julie Y. H.; Wu, Chih-Wei] Chang Gung Mem Hosp, Ctr Translat Res Biomed Sci, Kaohsiung Med Ctr, Kaohsiung 83301, Taiwan.
C3 Chang Gung Memorial Hospital
RP Wu, KLH (corresponding author), Chang Gung Mem Hosp, Ctr Translat Res Biomed Sci, Kaohsiung Med Ctr, Kaohsiung 83301, Taiwan.
EM klhwu@adm.cgmh.org.tw
RI Wu, Kay/ACD-1767-2022; Chan, Julie/X-5253-2019
OI Wu, Kay L.H./0000-0002-7297-6788
FU Chang Gung Memorial Hospital and National Science Council, Taiwan,
   Republic of China [CMRPG8A0801, CMRPG8B0581, NSC 102-2320-B-182A-008]
FX This study was supported in part by research grants CMRPG8A0801,
   CMRPG8B0581, and NSC 102-2320-B-182A-008 to KLHW from the Chang Gung
   Memorial Hospital and National Science Council, Taiwan, Republic of
   China.
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NR 55
TC 20
Z9 25
U1 0
U2 5
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1021-7770
EI 1423-0127
J9 J BIOMED SCI
JI J. Biomed. Sci.
PD JAN 27
PY 2014
VL 21
AR 8
DI 10.1186/1423-0127-21-8
PG 14
WC Cell Biology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Research & Experimental Medicine
GA AF3VS
UT WOS:000334641100001
PM 24467657
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Ferrer, MD
   Reynes, C
   Jiménez, L
   Malagraba, G
   Monserrat-Mesquida, M
   Bouzas, C
   Sureda, A
   Tur, JA
   Pons, A
AF Ferrer, Miguel D.
   Reynes, Clara
   Jimenez, Laura
   Malagraba, Gianluca
   Monserrat-Mesquida, Margalida
   Bouzas, Cristina
   Sureda, Antoni
   Tur, Josep A.
   Pons, Antoni
TI Nitrite Attenuates the In Vitro Inflammatory Response of Immune Cells to
   the SARS-CoV-2 S Protein without Interfering in the Antioxidant Enzyme
   Activation
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE antioxidants; COVID-19; inflammation; nitric oxide; nitrite; SARS-CoV-2
ID DOUBLE-STRANDED-RNA; NF-KAPPA-B; OXIDATIVE STRESS; RECOGNITION; NITRATE;
   SUPPLEMENTATION; MACROPHAGES; DYSFUNCTION; GENERATION; EXERCISE
AB SARS-CoV-2 induces a hyperinflammatory reaction due to the excessive release of cytokines during the immune response. The bacterial endotoxin lipopolysaccharide (LPS) contributes to the low-grade inflammation associated with the metabolic syndrome, enhancing the hyperinflammatory reaction induced by the SARS-CoV-2 infection. The intake of sodium nitrate, a precursor of nitrite and nitric oxide, influences the antioxidant and pro-inflammatory gene expression profile after immune stimulation with LPS in peripheral blood mononuclear cells from metabolic syndrome patients. We aimed to assess the inflammatory and antioxidant responses of immune cells from metabolic syndrome patients to exposure to the SARS-CoV-2 spike protein (S protein) together with LPS and the effect of nitrite in these responses. Whole blood samples obtained from six metabolic syndrome patients were cultured for 16 h at 37 degrees C with four different media: control medium, control medium plus LPS (100 ng/mL), control medium plus LPS (100 ng/mL) plus S protein (10 ng/mL), and control medium plus LPS (100 ng/mL) plus S protein (10 ng/mL) plus nitrite (5 mu M). Immune stimulation with the LPS/S protein enhanced nitrate biosynthesis from nitrite oxidation and probably from additional organic precursors. In vitro incubations with the LPS/S protein enhanced the expression and/or release of pro-inflammatory TNF alpha, IL-6, IL-1 beta, and TLR4, as well as the expression of the anti-inflammatory IL-1ra and IL-10 and antioxidant enzymes. Nitrite attenuated the pro- and anti-inflammatory response induced by the S protein without interfering with the activation of TLR4 and antioxidant enzyme expression, raising the possibility that nitrite could have potential as a coadjutant in the treatment of COVID-19.
C1 [Ferrer, Miguel D.; Reynes, Clara; Jimenez, Laura; Malagraba, Gianluca; Monserrat-Mesquida, Margalida; Bouzas, Cristina; Sureda, Antoni; Tur, Josep A.; Pons, Antoni] Univ Balear Isl, Res Grp Community Nutr & Oxidat Stress, IUNICS, Palma De Mallorca 07122, Spain.
   [Ferrer, Miguel D.; Monserrat-Mesquida, Margalida; Bouzas, Cristina; Sureda, Antoni; Tur, Josep A.; Pons, Antoni] Hlth Res Inst Balear Isl IdISBa, Palma De Mallorca 07120, Spain.
   [Monserrat-Mesquida, Margalida; Bouzas, Cristina; Sureda, Antoni; Tur, Josep A.; Pons, Antoni] Inst Hlth Carlos III, Ctr Invest Biomed Red Fisiopatol Obes & Nutr CIBER, Madrid 28029, Spain.
C3 Universitat de les Illes Balears; IUNICS; Institut Investigacio
   Sanitaria Illes Balears (IdISBa)
RP Ferrer, MD; Pons, A (corresponding author), Univ Balear Isl, Res Grp Community Nutr & Oxidat Stress, IUNICS, Palma De Mallorca 07122, Spain.; Ferrer, MD; Pons, A (corresponding author), Hlth Res Inst Balear Isl IdISBa, Palma De Mallorca 07120, Spain.; Pons, A (corresponding author), Inst Hlth Carlos III, Ctr Invest Biomed Red Fisiopatol Obes & Nutr CIBER, Madrid 28029, Spain.
EM miguel-david.ferrer@uib.es; gianluca.malagraba@uib.es;
   margalida.monserrat@uib.es; cristina.bouzas@uib.es;
   antoni.sureda@uib.es; pep.tur@uib.es; antonipons@uib.es
RI Tur, Josep/AAE-5748-2020; Sureda, Antoni/N-9588-2019; Mesquida,
   Margalida/AAB-4773-2019; Bouzas, Cristina/AAE-2069-2019; Jiménez,
   Laura/G-9885-2016; Reynés, Miguel/J-4206-2019; Pons, Antoni/L-4844-2014;
   Tur, Josep/F-5576-2014
OI Bouzas Velasco, Cristina/0000-0002-1407-8461; Monserrat Mesquida,
   Margalida/0000-0002-8856-135X; Pons, Antoni/0000-0003-2447-3868; Tur,
   Josep/0000-0002-6940-0761; Ferrer, Miguel D./0000-0003-1924-7727; ,
   Antoni/0000-0001-8656-6838
FU Instituto de Salud Carlos III through the Fondo de Investigacin para la
   Salud
FX No Statement Available
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NR 57
TC 0
Z9 0
U1 0
U2 1
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD MAR
PY 2024
VL 25
IS 5
AR 3001
DI 10.3390/ijms25053001
PG 15
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA KV6U3
UT WOS:001182785200001
PM 38474248
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Skop, V
   Malínská, H
   Trnovská, J
   Hüttl, M
   Cahová, M
   Blachnio-Zabielska, A
   Baranowski, M
   Burian, M
   Oliyarnyk, O
   Kazdová, L
AF Skop, Vojtech
   Malinska, Hana
   Trnovska, Jaroslava
   Huettl, Martina
   Cahova, Monika
   Blachnio-Zabielska, Agnieszka
   Baranowski, Marcin
   Burian, Martin
   Oliyarnyk, Olena
   Kazdova, Ludmila
TI Positive Effects of Voluntary Running on Metabolic Syndrome-Related
   Disorders in Non-Obese Hereditary Hypertriacylglycerolemic Rats
SO PLOS ONE
LA English
DT Article
ID BROWN ADIPOSE-TISSUE; FATTY-ACID-COMPOSITION; SOFT DRINK CONSUMPTION;
   INSULIN-RESISTANCE; SKELETAL-MUSCLE; EXPERIMENTAL-MODEL; OXIDATIVE
   STRESS; PHYSICAL-EXERCISE; LIPID-CONTENT; DIACYLGLYCEROL
AB While metabolic syndrome is often associated with obesity, 25% of humans suffering from it are not obese and the effect of physical activity remains unclear in such cases. Therefore, we used hereditary hypertriaclyglycerolemic (HHTg) rats as a unique model for studying the effect of spontaneous physical activity [voluntary running (VR)] on metabolic syndrome-related disorders, such as dyslipidemia, in non-obese subjects. Adult HHTg males were fed standard (CD) or high-sucrose (HSD) diets ad libitum for four weeks. Within both dietary groups, some of the rats had free access to a running wheel (CD+VR, HSD+VR), whereas the controls (CD, HSD) had no possibility of extra physical activity. At the end of the four weeks, we measured the effects of VR on various metabolic syndrome-associated parameters: (i) biochemical parameters, (ii) the content and composition of triacylglycerols (TAG), diacylglycerols (DAG), ceramides and membrane phospholipids, and (iii) substrate utilization in brown adipose tissue. In both dietary groups, VR led to various positive effects: reduced epididymal and perirenal fat depots; increased epididymal adipose tissue lipolysis; decreased amounts of serum TAG, non-esterified fatty acids and insulin; a higher insulin sensitivity index. While tissue ceramide content was not affected, decreased TAG accumulation resulted in reduced and modified liver, heart and skeletal muscle DAG. VR also had a beneficial effect on muscle membrane phospholipid composition. In addition, compared with the CD group, the CD+VR rats exhibited increased fatty acid oxidation and protein content in brown adipose tissue. Our results confirm that physical activity in a non-obese model of severe dyslipidemia has many beneficial effects and can even counteract the negative effects of sucrose consumption. Furthermore, they suggest that the mechanism by which these effects are modulated involves a combination of several positive changes in lipid metabolism.
C1 [Skop, Vojtech; Malinska, Hana; Trnovska, Jaroslava; Huettl, Martina; Cahova, Monika; Burian, Martin; Oliyarnyk, Olena; Kazdova, Ludmila] Inst Clin & Expt Med, Ctr Med Expt, Prague, Czech Republic.
   [Skop, Vojtech] Univ Chem & Technol, Dept Biochem & Microbiol, Prague, Czech Republic.
   [Blachnio-Zabielska, Agnieszka; Baranowski, Marcin] Med Univ Bialystok, Dept Physiol, Bialystok, Poland.
C3 Institute for Clinical & Experimental Medicine (IKEM); University of
   Chemistry & Technology, Prague; Medical University of Bialystok
RP Skop, V (corresponding author), Inst Clin & Expt Med, Ctr Med Expt, Prague, Czech Republic.
EM skov@ikem.cz
RI Cahova, Monika/Z-1568-2018; Oliyarnyk, Olena/Q-6380-2019;
   Blachnio-Zabielsk, Agnieszka/A-4879-2018; Stefanadis,
   Christodoulos/ABH-2232-2020; Skop, Vojtech/LBI-2231-2024; Baranowski,
   Marcin/F-6718-2011
OI Cahova, Monika/0000-0003-2640-5084; Oliyarnyk,
   Olena/0000-0002-4912-6187; Trnovska, Jaroslava/0000-0001-6468-8244;
   Stefanadis, Christodoulos/0000-0001-5974-6454; Blachnio-Zabielska,
   Agnieszka/0000-0002-8055-0576; Skop, Vojtech/0000-0002-4685-4429;
   Baranowski, Marcin/0000-0002-3714-5815
FU Grant Agency of the Czech Republic [P301/11/2418]; MH CZ - DRO
   ("Institute for Clinical and Experimental Medicine - IKEM") [IN 0002301]
FX This work was supported by grant, P301/11/2418, from the Grant Agency of
   the Czech Republic and grant, MH CZ - DRO ("Institute for Clinical and
   Experimental Medicine - IKEM, IN 0002301"). The funders had no role in
   study design, data collection and analysis, decision to publish, or
   preparation of the manuscript.
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NR 74
TC 8
Z9 9
U1 0
U2 14
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD APR 1
PY 2015
VL 10
IS 4
AR e0122768
DI 10.1371/journal.pone.0122768
PG 19
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA CE9AM
UT WOS:000352135600124
PM 25830228
OA Green Submitted, gold, Green Published
DA 2025-06-11
ER

PT J
AU Vancampfort, D
   Rosenbaum, S
   Probst, M
   Connaughton, J
   du Plessis, C
   Yamamoto, T
   Stubbs, B
AF Vancampfort, Davy
   Rosenbaum, Simon
   Probst, Michel
   Connaughton, Joanne
   du Plessis, Christy
   Yamamoto, Taisei
   Stubbs, Brendon
TI Top 10 research questions to promote physical activity in bipolar
   disorders: A consensus statement from the International Organization of
   Physical Therapists in Mental Health
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Physical activity; Exercise; Mood
ID METABOLIC SYNDROME; EXERCISE; ADULTS; METAANALYSIS; PREVALENCE;
   MORTALITY; DISEASE; ILLNESS; RISK; SCHIZOPHRENIA
AB Background: Research has only recently started to consider the importance and applicability of physical activity (PA) for people with bipolar disorder (BD). The aim of the current study is to highlight 10 pertinent PA research questions in people with BD.
   Methods: The International Organization of Physical Therapy in Mental Health executed a consultation with all National organizations (n=13) to identify the most salient questions to guide future research on PA in BD.
   Results: We identified the following 10 questions: (1) What are the benefits of PA for people with BD? (2) What are the most prominent safety issues for PA prescription in BD? (3) What is the optimal PA prescription for people with BD? (4) What are the key barriers to PA among people with BD? (5) What are the most effective motivational strategies for ensuring PA adoption and maintenance in BD? (6) How do we translate PA research into community practice? (7) If one treatment goal is increased physical activity, what type of professionals are needed as part of a multidisciplinary team? (8) How do we incorporate PA as a vital sign in clinical practice? (9) How can we prevent sedentary behavior in BD? (10) What is the most appropriate PA assessment method?
   Limitations: We did not consult people with BD.
   Conclusions: Addressing these questions is critical for developing evidence-based approaches for promoting and sustaining an active lifestyle in BD. Ultimately, achieving this will reduce the burden of cardiovascular disease and improve the quality of life of this population. (C) 2016 Elsevier B.V. All rights reserved.
C1 [Vancampfort, Davy; Probst, Michel] KU Leuven Univ Leuven, Dept Rehabil Sci, Leuven, Belgium.
   [Vancampfort, Davy] KU Leuven Univ Leuven, Univ Psychiat Ctr, Leuven, Belgium.
   [Rosenbaum, Simon] Univ New S Wales, Sch Psychiat, Sydney, NSW, Australia.
   [Connaughton, Joanne] Univ Notre Dame, Sch Physiotherapy, Fremantle, WA, Australia.
   [du Plessis, Christy] Univ Orange Free State, Bloemfontein, South Africa.
   [Yamamoto, Taisei] Kobe Gakuin Univ, Dept Rehabil Med, Kobe, Hyogo 65121, Japan.
   [Stubbs, Brendon] South London & Maudsley NHS Fdn Trust, Physiotherapy Dept, London, England.
   [Stubbs, Brendon] Kings Coll London, Inst Psychiat, Hlth Serv & Populat Res Dept, London WC2R 2LS, England.
C3 KU Leuven; KU Leuven; University of New South Wales Sydney; The
   University of Notre Dame Australia; University of the Free State; Kobe
   Gakuin University; South London & Maudsley NHS Trust; University of
   London; King's College London
RP Vancampfort, D (corresponding author), KU Leuven Univ Leuven, Univ Psychiat Ctr, Leuvensesteenweg 517, B-3070 Kortenberg, Belgium.
EM davy.vancampfort@uc-kortenberg.be
RI Vancampfort, Davy/AAD-1987-2019; Probst, Michel/ABE-6137-2020; Stubbs,
   Brendon/X-1904-2018; Rosenbaum, Simon/Y-3241-2019; Stubbs,
   Brendon/C-5696-2015
OI Stubbs, Brendon/0000-0001-7387-3791; Rosenbaum,
   Simon/0000-0002-8984-4941
FU Grants-in-Aid for Scientific Research [25300019, 15K01695] Funding
   Source: KAKEN
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NR 52
TC 15
Z9 17
U1 0
U2 21
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD MAY
PY 2016
VL 195
BP 82
EP 87
DI 10.1016/j.jad.2016.01.046
PG 6
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA DF3PP
UT WOS:000371257400010
PM 26874245
DA 2025-06-11
ER

PT J
AU Auvinen, HE
   Romijn, JA
   Biermasz, NR
   Havekes, LM
   Smit, JWA
   Rensen, PCN
   Pereira, AM
AF Auvinen, H. E.
   Romijn, J. A.
   Biermasz, N. R.
   Havekes, L. M.
   Smit, J. W. A.
   Rensen, P. C. N.
   Pereira, A. M.
TI Effects of High Fat Diet on the Basal Activity of the
   Hypothalamus-Pituitary-Adrenal Axis in Mice: A Systematic Review
SO HORMONE AND METABOLIC RESEARCH
LA English
DT Review
DE corticosterone; diet-induced obesity; metabolic syndrome
ID 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1; METABOLIC SYNDROME;
   ADIPOSE-TISSUE; GLUCOCORTICOID-RECEPTOR; INSULIN-RESISTANCE; VISCERAL
   OBESITY; STRESS; INHIBITION; EXPRESSION; MORTALITY
AB Hypothalamus-pituitary-adrenal-axis activity is suggested to be involved in the pathophysiology of the metabolic syndrome. In diet-induced obesity mouse models, features of the metabolic syndrome are induced by feeding high fat diet. However, the models reveal conflicting results with respect to the hypothalamus-pituitary-adrenal-axis activation. The aim of this review was to assess the effects of high fat feeding on the activity of the hypothalamus-pituitary-adrenal-axis in mice. PubMed, EMBASE, Web of Science, the Cochrane database, and Science Direct were electronically searched and reviewed by 2 individual researchers. We included only original mouse studies reporting parameters of the hypothalamus-pituitary-adrenal-axis after high fat feeding, and at least 1 basal corticosterone level with a proper control group. Studies with adrenalectomized mice, transgenic animals only, high fat diet for less than 2 weeks, or other interventions besides high fat diet, were excluded. 20 studies were included. The hypothalamus-pituitary-adrenal-axis evaluation was the primary research question in only 5 studies. Plasma corticosterone levels were unchanged in 40%, elevated in 30%, and decreased in 20% of the studies. The effects in the peripheral tissues and the central nervous system were also inconsistent. However, major differences were found between mouse strains, experimental conditions, and the content and duration of the diets. This systematic review demonstrates that the effects of high fat feeding on the basal activity of the hypothalamus-pituitary-adrenal-axis in mice are limited and inconclusive. Differences in experimental conditions hamper comparisons and accentuate the need for standardized evaluations to discern the effects of diet-induced obesity on the hypothalamus-pituitary-adrenal-axis.
C1 [Auvinen, H. E.; Romijn, J. A.; Biermasz, N. R.; Havekes, L. M.; Smit, J. W. A.; Rensen, P. C. N.; Pereira, A. M.] Leiden Univ, Med Ctr, Dept Endocrinol & Metab Dis, NL-2300 RC Leiden, Netherlands.
   [Havekes, L. M.] Gabius Lab, TNO Metab Hlth Res, Leiden, Netherlands.
C3 Leiden University - Excl LUMC; Leiden University; Leiden University
   Medical Center (LUMC); Netherlands Organization Applied Science Research
RP Auvinen, HE (corresponding author), Leiden Univ, Med Ctr, Dept Endocrinol & Metab Dis, Room C5-R61,Albinusdreef 2,POB 9600, NL-2300 RC Leiden, Netherlands.
EM h.e.auvinen@lumc.nl
RI Biermasz, Nienke/ABE-9436-2021; Rensen, Patrick/D-7176-2018; Pereira,
   Alberto M./Q-7175-2017; smit, johannes/H-8091-2014
OI Rensen, Patrick/0000-0002-8455-4988; Pereira, Alberto
   M./0000-0002-1194-9866; smit, johannes/0000-0003-1052-9314
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NR 37
TC 22
Z9 26
U1 0
U2 14
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0018-5043
EI 1439-4286
J9 HORM METAB RES
JI Horm. Metab. Res.
PD DEC
PY 2011
VL 43
IS 13
BP 899
EP 906
DI 10.1055/s-0031-1291305
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 863IG
UT WOS:000298155400001
PM 22068812
DA 2025-06-11
ER

PT J
AU Dogan, A
   Oylumlu, M
AF Dogan, Adnan
   Oylumlu, Muhammed
TI Increased monocyte-to-HDL cholesterol ratio is related to cardiac
   syndrome X
SO ACTA CARDIOLOGICA
LA English
DT Article
DE Cardiac syndrome X; inflammation markers; monocyte-to-HDL cholesterol
   ratio
ID C-REACTIVE PROTEIN; NORMAL CORONARY ARTERIOGRAMS; LEFT-VENTRICULAR
   FUNCTION; INTIMA-MEDIA THICKNESS; SYSTEMIC INFLAMMATION; ENDOTHELIAL
   DYSFUNCTION; ARTERY-DISEASE; PATHOPHYSIOLOGY; ASSOCIATION; PREDICTS
AB Objective: Cardiac syndrome X (CSX) is typically identified with ischaemia in treadmill exercise test or stress myocardial perfusion scintigraphy as well as angina-like chest pain without stenosis in coronary angiography. The purpose of the present study is to investigate the association between cardiac syndrome X and monocyte-to-HDL cholesterol ratio (MHR) which is a new marker associated with inflammation.
   Patients and methods: A total of 230 patients (105 patients with cardiac syndrome X and 125 normal controls) were included in the study. Peripheral venous blood samples were drawn from all study population before coronary angiography for measuring MHR and other haematological parameters.
   Results: The patients with cardiac syndrome X were more likely to have higher platelet counts, plateletcrit (PCT), monocyte count and MHR values. Monocyte count and MHR of the CSX group were significantly higher than the control group [0.53 (0.35-1) vs. 0.49 (0.23-0.96); p = .002, .011 (0.006-0.038) vs. 0.010 (0.004-0.034); p < .001, respectively]. HDL-cholesterol levels of the CSX group were significantly lower than the control groups (46.3 +/- 10.1 vs. 49.6 +/- 11.6; p = .021). Higher MHR and PCT values were found to be associated with the presence of CSX by multivariate logistic regression analysis.
   Conclusions: Elevated MHR level independently was found in association with the presence of CSX. The value of MHR appears additive to conventional expensive methods commonly used in CSX prediction.
C1 [Dogan, Adnan; Oylumlu, Muhammed] Dumlupinar Univ, Dept Cardiol, Sch Med, Kutahya, Turkey.
C3 Dumlupinar University
RP Dogan, A (corresponding author), Dumlupinar Univ, Dept Cardiol, TR-43000 Kutahya, Turkey.
EM doganadnan01@gmail.com
OI Oylumlu, Muhammed/0000-0003-4219-9655
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NR 35
TC 26
Z9 26
U1 0
U2 8
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0001-5385
EI 1784-973X
J9 ACTA CARDIOL
JI Acta Cardiol.
PY 2017
VL 72
IS 5
BP 516
EP 521
DI 10.1080/00015385.2017.1299521
PG 6
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA FK1AR
UT WOS:000413212600002
PM 28853337
DA 2025-06-11
ER

PT J
AU Vercesi, AE
   Castilho, RF
   Kowaltowski, AJ
   Oliveira, HCF
AF Vercesi, Anibal E.
   Castilho, Roger F.
   Kowaltowski, Alicia J.
   Oliveira, Helena C. F.
TI Mitochondrial energy metabolism and redox state in dyslipidemias
SO IUBMB LIFE
LA English
DT Article; Proceedings Paper
CT 10th IUBMB Conference 2007
CY MAY 21-25, 2007
CL Salvador, BRAZIL
DE mitochondria; metabolic syndrome; hyperlipidemia; free radicals; K+
   channel; oxidative stress
ID LOW-DENSITY-LIPOPROTEIN; NADP(+)-DEPENDENT ISOCITRATE DEHYDROGENASE; COA
   REDUCTASE INHIBITORS; PERMEABILITY TRANSITION; REACTIVE OXYGEN;
   UNCOUPLING PROTEINS; CELL-DEATH; OXIDATIVE MODIFICATION;
   PYRIDINE-NUCLEOTIDES; ENDOTHELIAL-CELLS
AB Changes in mitochondrial function are intimately associated with metabolic diseases. Here, we review recent evidence relating alterations in mitochondrial energy metabolism, ion transport and redox state in hypercholesterolemia and hypertriglyceridemia. We focus mainly on changes in mitochondrial respiration, K+ and Ca2+ transport, reactive oxygen species generation and susceptibility to mitochondrial permeability transition.
C1 Univ Estadual Campinas, Fac Ciencias Med, Dept Patol Clin, BR-13083877 Campinas, SP, Brazil.
   Univ Sao Paulo, Inst Quim, Dept Bioquim, BR-01498 Sao Paulo, Brazil.
   Univ Estadual Campinas, Inst Biol, Dept Fisiol & Biofis, Campinas, Brazil.
C3 Universidade Estadual de Campinas; Universidade de Sao Paulo;
   Universidade de Sao Paulo; Universidade Estadual de Campinas
RP Vercesi, AE (corresponding author), Univ Estadual Campinas, Fac Ciencias Med, Dept Patol Clin, BR-13083877 Campinas, SP, Brazil.
EM anibal@unicamp.br
RI Vercesi, Aníbal/C-8767-2012; Castilho, Roger/G-3906-2012; Kowaltowski,
   Alicia/H-8698-2012; Oliveira, Helena/C-1343-2013
OI Frigerio Castilho, Roger/0000-0003-2338-8717; Oliveira,
   Helena/0000-0003-0119-6992; Vercesi, Anibal Eugenio/0000-0001-6671-7125
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NR 53
TC 19
Z9 20
U1 0
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1521-6543
EI 1521-6551
J9 IUBMB LIFE
JI IUBMB Life
PY 2007
VL 59
IS 4-5
BP 263
EP 268
DI 10.1080/15216540601178091
PG 6
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Biochemistry & Molecular Biology; Cell Biology
GA 171SX
UT WOS:000246756800018
PM 17505963
OA Bronze
DA 2025-06-11
ER

PT J
AU Bulboaca, A
   Bolboaca, SD
   Suci, S
AF Bulboaca, Adriana
   Bolboaca, Sorana D.
   Suci, Soimita
TI Protective effect of curcumin in fructose-induced metabolic syndrome and
   in streptozotocin-induced diabetes in rats
SO IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
LA English
DT Article
DE Curcumin; Diabetes mellitus; Fructose; Metabolic syndrome Oxidative
   stress; Streptozotocin-induced diabetes
ID ROSTRAL VENTROLATERAL MEDULLA; OXIDATIVE STRESS; NITRIC-OXIDE;
   HYPERTENSION; GLUCOSE; INSULIN; MALONDIALDEHYDE; GLUTATHIONE;
   INHIBITION; CONTRIBUTE
AB Objective: The aim of this study was to investigate the effect of pre-treatment with curcumin on metabolic changes induced by two different pathophysiological mechanisms in rats (fructose diet and streptozotocin (STZ)-induced diabetes mellitus).
   Materials and Methods: Five groups with 10 rats per group were investigated: control group (healthy rats), fructose diet groups without any pre-treatment (FD), fructose diet groups with curcumin pre-treatment (FDC), STZ-induced diabetes mellitus without any pre-treatment (SID) and STZ-induced diabetes mellitus with curcumin pre-treatment (SIDC). Systolic blood pressure, and several metabolic and oxidative stress parameters were assessed.
   Results: Systolic blood pressure significantly increased in all groups compared with control group (P<0.001), with significantly lower values on groups with curcumin pre-treatment compared with the group without any pre-treatment and same inducement (FDS vs. FD P<0.0001, SIDC vs. SID P<0.0001). High-density lipoprotein (HDL)-cholesterol was significantly lower in all groups compared with control group (P<0.05) while triglycerides (P<0.05), aspartate aminotransferase (AST, P<0.0001) and alanine aminotransferase (ALT, P<0.0001) were significantly higher. Within the group with same induction, curcumin pre-treatment significantly improved metabolic (total cholesterol, glycaemia, triglycerides, AST, ALT; P<0.05) and oxidative stress parameters (total oxidative status (NOx), Thiol, and malondialdehyde (MDA), P<0.02) compared to untreated groups.
   Conclusion: The pre-treatment with curcumin in our experimental models significantly improved metabolic (total cholesterol, triglycerides, AST and ALT) as well as oxidative stress parameters (MDA, NOx, and Thiol) in both fructose diet and in STZ-induced diabetes in rats. These properties of curcumin may serve to improve the metabolic and oxidative stress conditions in patients with these pathological features.
C1 [Bulboaca, Adriana] Iuliu Hatieganu Univ Med & Pharm Cluj Napoca, Dept Pathophysiol, Victor Babes St 2-4, Cluj Napoca 400012, Romania.
   [Bolboaca, Sorana D.] Iuliu Hatieganu Univ Med & Pharm Cluj Napoca, Dept Biostat & Med Informat, Louis Pasteur St 6, Cluj Napoca 400349, Romania.
   [Suci, Soimita] Iuliu Hatieganu Univ Med & Pharm Cluj Napoca, Dept Physiol, Clinicilor St 1, Cluj Napoca 400006, Romania.
C3 Iuliu Hatieganu University of Medicine & Pharmacy; Iuliu Hatieganu
   University of Medicine & Pharmacy; Iuliu Hatieganu University of
   Medicine & Pharmacy
RP Bolboaca, SD (corresponding author), Iuliu Hatieganu Univ Med & Pharm Cluj Napoca, Dept Biostat & Med Informat, 6 Louis Pasteur, Cluj Napoca 400349, Romania.
EM sbolboaca@umfcluj.ro
RI Bulboaca, Adriana-Elena/S-8093-2017; Suciu, Şoimiţa/S-8470-2017;
   Bolboaca, Sorana D./E-4457-2010
OI Suciu, Soimita Mihaela/0000-0003-2208-5132; Bolboaca, Sorana
   D./0000-0002-2342-4311
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NR 51
TC 32
Z9 33
U1 0
U2 14
PU MASHHAD UNIV MED SCIENCES
PI MASHHAD
PA VICE-CHANCELLOR FOR RES CTR OFF IJBMS, DANESHGAH ST, PO BOX 9138813944 -
   445, MASHHAD, 00000, IRAN
SN 2008-3866
EI 2008-3874
J9 IRAN J BASIC MED SCI
JI Iran. J. Basic Med. Sci.
PD JUN
PY 2016
VL 19
IS 6
BP 585
EP 593
PG 9
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA DR8VX
UT WOS:000380177400002
PM 27482338
DA 2025-06-11
ER

PT J
AU Kuhad, A
   Chopra, K
AF Kuhad, Anurag
   Chopra, Kanwaljit
TI Highlights from the 3rd international conference on polyphenols and
   health
SO DRUGS OF THE FUTURE
LA English
DT Review
ID FRENCH PARADOX
AB The 3rd International Conference on Polyphenols and Health (ICPH), held in Kyoto, Japan, on November 25-28, 2007, focused on recent advances in polyphenolic research in different fields, from natural characterization, chemistry, bioavailability, metabolism, biological effects, formulations, epidemiological and interventional studies to clinical trials. The main focus of the conference was the molecular mechanism underlying pharmaceutical application of polyphenols in a plethora of disease conditions, including inflammation, cancer, metabolic syndrome, diabetes, allergy, cognition and oxidative stress-related pathologies.
C1 [Kuhad, Anurag; Chopra, Kanwaljit] Panjab Univ, Pharmacol Res Lab, Univ Inst Pharmaceut Sci, UCG Ctr Adv Studies, Chandigarh 160014, India.
C3 Panjab University
RP Kuhad, A (corresponding author), Panjab Univ, Pharmacol Res Lab, Univ Inst Pharmaceut Sci, UCG Ctr Adv Studies, Chandigarh 160014, India.
EM anurag_pu@yahoo.com
OI Chopra, Kanwaljit/0000-0001-5898-6093
CR AABY K, 2007, 3 INT C POL HLTH ICP
   ACTISGORETTA L, 2007, 3 INT C POL HLTH ICP
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NR 265
TC 4
Z9 5
U1 0
U2 2
PU PROUS SCIENCE, SAU-THOMSON REUTERS
PI BARCELONA
PA 398 PROVENCA, 08025 BARCELONA, SPAIN
SN 0377-8282
EI 2013-0368
J9 DRUG FUTURE
JI Drug Future
PD MAR
PY 2008
VL 33
IS 3
BP 249
EP 287
PG 39
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 284GK
UT WOS:000254694700009
DA 2025-06-11
ER

PT J
AU Takayanagi, Y
   Obana, A
   Muto, S
   Asaoka, R
   Tanito, M
   Ermakov, IV
   Bernstein, PS
   Gellermann, W
AF Takayanagi, Yuji
   Obana, Akira
   Muto, Shigeki
   Asaoka, Ryo
   Tanito, Masaki
   Ermakov, Igor V.
   Bernstein, Paul S.
   Gellermann, Werner
TI Relationships between Skin Carotenoid Levels and Metabolic Syndrome
SO ANTIOXIDANTS
LA English
DT Article
DE metabolic syndrome; health examination population; skin carotenoids;
   oxidative stress; Veggie Meter
ID 3RD NATIONAL-HEALTH; CIGARETTE-SMOKING; SERUM CAROTENOIDS; LOWER
   PREVALENCE; MACULAR PIGMENT; DIETARY-INTAKE; US ADULTS; ANTIOXIDANT;
   PLASMA; LUTEIN
AB Carotenoids have potential antioxidant and anti-inflammatory effects; their protective roles are of particular interest in the pathogenesis of metabolic syndrome (MetS). The reflection spectroscopy method has been recently developed to noninvasively measure skin carotenoid (SC) levels, which highly correlates with serum concentration of carotenoids. The relationship between SC levels and metabolic syndrome has been investigated. We aimed to identify the differences in patient characteristics and SC levels between participants with and without MetS in a large health examination population. In addition, the relationships between SC levels and various clinical parameters related to MetS were investigated. SC levels were measured using a reflection spectroscopy. A total of 1812 Japanese participants (859 male, 953 female; mean age +/- standard deviation (SD), 57.8 +/- 11.0 years) comprised the study population, i.e., participants with MetS (n = 151) and those without MetS (n = 1661). Multivariate logistic regression analysis was performed to identify variables associated with MetS. Compared to controls (377.3 +/- 122.8), SC indices were significantly lower in patients with MetS (340.7 +/- 112.5, p = 0.0004). Multivariate models also suggested that lower SC was significantly associated with MetS after adjustment for age, sex, smoking habit, and other potential risk factors for MetS. Furthermore, male gender (p < 0.0001), smoking habit (p < 0.0001) and worse lipid profiles (i.e., serum triglyceride (r = -0.1039, p < 0.0001), high-density lipoprotein (r = 0.1259, p < 0.0001), and usage of hypolipidemic agents (p = 0.0340)) were significantly associated with lower SC levels. The current study indicated that lower SC levels were significantly associated with MetS. This study highlights the antioxidant capacity of carotenoids in patients with MetS and the clinical utility of non-invasive and cost-effective SC measurement to detect participants who are at risk of developing MetS in a large population.
C1 [Takayanagi, Yuji; Tanito, Masaki] Shimane Univ, Fac Med, Dept Ophthalmol, Izumo, Shimane 6938501, Japan.
   [Obana, Akira; Asaoka, Ryo] Seirei Hamamatsu Gen Hosp, Dept Ophthalmol, Hamamatsu, Shizuoka 4308558, Japan.
   [Obana, Akira] Hamamatsu Univ, Sch Med, Preeminent Med Photon Educ & Res Ctr, Dept Med Spect,Inst Med Photon Res, Hamamatsu, Shizuoka 4313192, Japan.
   [Muto, Shigeki] Seirei Social Welf Community, Seirei Ctr Hlth Promot & Prevent Med, Hamamatsu, Shizuoka 4300906, Japan.
   [Ermakov, Igor V.; Gellermann, Werner] Longev Link Corp, Salt Lake City, UT 84108 USA.
   [Bernstein, Paul S.] Univ Utah, Sch Med, Moran Eye Ctr, Dept Ophthalmol & Visual Sci, Salt Lake City, UT 84132 USA.
C3 Shimane University; Hamamatsu University School of Medicine; Utah System
   of Higher Education; University of Utah
RP Obana, A (corresponding author), Seirei Hamamatsu Gen Hosp, Dept Ophthalmol, Hamamatsu, Shizuoka 4308558, Japan.; Obana, A (corresponding author), Hamamatsu Univ, Sch Med, Preeminent Med Photon Educ & Res Ctr, Dept Med Spect,Inst Med Photon Res, Hamamatsu, Shizuoka 4313192, Japan.
EM y.takayanagi1008@gmail.com; obana@sis.seirei.or.jp;
   smuto@sis.seirei.or.jp; ryoasa0120@googlemail.com;
   mtanito@med.shimane-u.ac.jp; iv.ermakov@outlook.com;
   paul.bernstein@hsc.utah.edu; wbgellermann@gmail.com
OI Obana, Akira/0000-0001-7930-3618; Bernstein, Paul/0000-0002-4228-7666
FU Ministry of Education, Culture, Sports, Science and Technology of Japan
   [19H01114, 18KK0253, 20K09784]; Strategic Promotion for practical
   application of Innovative medical Technology (TR-SPRINT) from the Japan
   Agency for Medical Research and Development (AMED); Japan Science and
   Technology Agency; National Eye Institute [EY11600, EY14800]; Research
   to Prevent Blindness
FX R.A. received grants as follows: grants (19H01114, 18KK0253, and
   20K09784) from the Ministry of Education, Culture, Sports, Science and
   Technology of Japan (RA), The Translational Research program; Strategic
   Promotion for practical application of Innovative medical Technology
   (TR-SPRINT) from the Japan Agency for Medical Research and Development
   (AMED) (RA), grant AIP acceleration research from the Japan Science and
   Technology Agency (RA). P.S.B. received grants as follows: National Eye
   Institute grants EY11600 and EY14800. And an unrestricted departmental
   grant from Research to Prevent Blindness (there is no grant number).
   Other authors received no grands.
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NR 43
TC 17
Z9 18
U1 0
U2 2
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD JAN
PY 2022
VL 11
IS 1
AR 14
DI 10.3390/antiox11010014
PG 11
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA ZD8EJ
UT WOS:000758428000001
PM 35052521
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Gupte, SA
AF Gupte, Sachin A.
TI Targeting the Pentose Phosphate Pathway in Syndrome X-Related
   Cardiovascular Complications
SO DRUG DEVELOPMENT RESEARCH
LA English
DT Review
DE syndrome X; hyperglycemia; hyperinsulinemia; diabetes; obesity;
   hyperlipidemia; glucose-6-phosphate dehydrogenase; pentose phosphate
   pathway; reactive oxygen species
ID GLUCOSE-6-PHOSPHATE-DEHYDROGENASE DEFICIENCY DECREASES;
   DEHYDROGENASE-DERIVED NADPH; SMOOTH-MUSCLE-CELLS; OXIDATIVE STRESS;
   SUPEROXIDE-PRODUCTION; NAD(P)H OXIDASE; NITRIC-OXIDE;
   PHOSPHATIDYLINOSITOL 3-KINASE; VASCULAR SUPEROXIDE; THERAPEUTIC TARGET
AB Syndrome X is a combination or co-occurrence of several known cardiovascular risk factors (including central obesity, dyslipidemias, fatty liver disease, hyperinsulinemia, insulin resistance, and hypertension) that affects at least one in five people in developed countries. Syndrome X shortens life and increases morbidity by contributing to the development of both diabetes and cardiovascular disease. Type 1 or 2 diabetes affects approximately 170 million people globally, and these numbers are rapidly rising. In patients with diabetes, vascular diseases develop early and progress at an accelerated rate. It has recently become evident that glucose-6-phosphate dehydrogenase (G6PD), the rate-limiting enzyme in the pentose-phosphate pathway and its reaction products play key roles in regulating vascular function. Epidemiological studies have also shown that G6PD deficiency markedly reduces retinopathy and mortality due to cardiovascular diseases in males from certain Mediterranean regions. Conversely, G6PD expression and activity are upregulated in rat and mouse models of obesity, hyperglycemia, and hyperinsulinemia, and a role for G6PD in the development of insulin resistance in type 2 diabetes has been proposed. Unfortunately, no selective drugs are available to validate the hypothesis that G6PD and its products are involved in the development of syndrome X in humans. This review discusses the potential mechanisms by which G6PD could be implicated in vascular diseases in syndrome X and the need to develop new approaches, including new drugs and molecular tools, to ameliorate diabetes-induced vascular dysfunction and vasculopathies. Drug Dev Res 71:161-167, 2010. (C) 2010 Wiley-Liss, Inc.
C1 [Gupte, Sachin A.] Univ S Alabama, Coll Med, Dept Biochem & Mol Biol, Mobile, AL USA.
C3 University of South Alabama
RP Gupte, SA (corresponding author), Univ S Alabama, Dept Biochem & Mol Biol, Coll Med, MSB 2312,307 Univ Blvd, N Mobile, AL 36688 USA.
EM sagutpe@usouthal.edu
FU AHA [0435070N]; NIH [RO1HL085352]; American Heart Association (AHA)
   [0435070N] Funding Source: American Heart Association (AHA)
FX Grant sponsor: AHA; Grant number: 0435070N; Grant Sponsor: NIH; Grant
   number: RO1HL085352.
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NR 47
TC 22
Z9 26
U1 1
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0272-4391
EI 1098-2299
J9 DRUG DEVELOP RES
JI Drug Dev. Res.
PD MAY
PY 2010
VL 71
IS 3
BP 161
EP 167
DI 10.1002/ddr.20359
PG 7
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 604LY
UT WOS:000278281700001
PM 20711518
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Sangouni, AA
   Taghdir, M
   Mirahmadi, J
   Sepandi, M
   Parastouei, K
AF Sangouni, Abbas Ali
   Taghdir, Maryam
   Mirahmadi, Javad
   Sepandi, Mojtaba
   Parastouei, Karim
TI Effects of curcumin and/or coenzyme Q10 supplementation on metabolic
   control in subjects with metabolic syndrome: a randomized clinical trial
SO NUTRITION JOURNAL
LA English
DT Article
DE Metabolic syndrome; Curcumin; Coenzyme Q10; Lipid profile; Blood
   pressure; Body composition
ID DOUBLE-BLIND; HYPERTENSIVE PATIENTS; INSULIN-RESISTANCE; OXIDATIVE
   STRESS; LIPID PROFILES; INFLAMMATION; ADIPOGENESIS; THERAPY; OBESITY;
   DIET
AB Background: Metabolic syndrome (MetS) as a cluster of conditions including hyperlipidemia, hypertension, hyperglycemia, insulin resistance, and abdominal obesity is linked to cardiovascular diseases and type 2 diabetes. Evidence suggested that intake of curcumin and coenzyme Q10 may have therapeutic effects in the management of MetS.
   Aims: We investigated the effects of curcumin and/or coenzyme Q10 supplementation on metabolic syndrome components including systolic blood pressure (SBP), diastolic blood pressure (DBP), waist circumference (WC), triglyceride (TG), high density lipoprotein-cholesterol (HDL-c) and fasting plasma glucose (FPG) as primary outcomes, and total cholesterol (TC), low density lipoprotein-cholesterol (LDL-c) and body mass index (BMI) as secondary outcomes in subjects with MetS.
   Methods: In this 2 x 2 factorial, randomized, double-blinded, placebo-controlled study, 88 subjects with MetS were randomly assigned into four groups including curcumin plus placebo (CP), or coenzyme Q10 plus placebo (QP), or curcumin plus coenzyme Q10 (CQ), or double placebo (DP) for 12 weeks.
   Results: The CP group compared with the three other groups showed a significant reduction in HDL-c (P = 0.001), TG (P < 0.001), TC (P < 0.001), and LDL-c (P < 0.001). No significant differences were seen between the four groups in terms of SBP, DBP, FPG, WC, BMI and weight.
   Conclusion: Curcumin improved dyslipidemia, but had no effect on body composition, hypertension and glycemic control. Furthermore, coenzyme Q10 as well as the combination of curcumin and coenzyme Q10 showed no therapeutic effects in subjects with MetS. The trial was registered on 09/21/2018 at the Iranian clinical trials website (IRCT20180201038585N2), URL: https://www.irct.ir/trial/32518.
C1 [Sangouni, Abbas Ali; Taghdir, Maryam; Sepandi, Mojtaba; Parastouei, Karim] Baqiyatallah Univ Med Sci, Hlth Res Ctr, Life Style Inst, Tehran, Iran.
   [Sangouni, Abbas Ali] Shahid Sadoughi Univ Med Sci, Sch Publ Hlth, Dept Nutr, Yazd, Iran.
   [Mirahmadi, Javad] Baqiyatallah Univ Med Sci, Student Res Comm, Tehran, Iran.
C3 Baqiyatallah University of Medical Sciences (BMSU); Shahid Sadoughi
   University of Medical Sciences; Baqiyatallah University of Medical
   Sciences (BMSU)
RP Parastouei, K (corresponding author), Baqiyatallah Univ Med Sci, Hlth Res Ctr, Life Style Inst, Tehran, Iran.
EM parastouei@gmail.com
RI Sangouni, Abbas Ali/IUP-7744-2023; Sepandi, Mojtaba/I-8561-2014;
   Taghdir, Maryam/U-3122-2018
FU Baqiyatallah University of Medical Sciences
FX This study was supported by the Baqiyatallah University of Medical
   Sciences. This was a financial support for student thesis process
   including laboratory works, and provide kits as well as supplements.
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NR 51
TC 25
Z9 25
U1 1
U2 12
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1475-2891
J9 NUTR J
JI Nutr. J.
PD OCT 3
PY 2022
VL 21
IS 1
AR 62
DI 10.1186/s12937-022-00816-7
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 5B5BB
UT WOS:000863583900001
PM 36192751
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Guerdjikova, AI
   Mori, N
   Casuto, LS
   McElroy, SL
AF Guerdjikova, Anna, I
   Mori, Nicole
   Casuto, Leah S.
   McElroy, Susan L.
TI Update on Binge Eating Disorder
SO MEDICAL CLINICS OF NORTH AMERICA
LA English
DT Article
DE Binge eating disorder; Female binge eating; Treatment; Gender; Sex
   differences; Eating dysregulation
ID COGNITIVE-BEHAVIORAL THERAPY; PRIMARY-CARE; GENDER-DIFFERENCES; OVARIAN
   HORMONES; WEIGHT-LOSS; METABOLIC SYNDROME; BULIMIA-NERVOSA;
   SEX-DIFFERENCES; OBESE MEN; WOMEN
AB Binge eating disorder (BED) is the most common eating disorder and an important public health problem. Lifetime prevalence of BED in the United States is 2.6%. In contrast to other eating disorders, the female to male ratio in BED is more balanced. BED co-occurs with a plethora of psychiatric disorders, most commonly mood and anxiety disorders. BED is also associated with obesity and its numerous complications. Although BED is similar in men and women in presentation and treatment outcomes, there are some key neurobiological differences that should be taken in consideration when personalizing treatment.
C1 [Guerdjikova, Anna, I; Mori, Nicole; Casuto, Leah S.; McElroy, Susan L.] Lindner Ctr Hope, 4075 Old Western Row Rd, Mason, OH 45040 USA.
   [Guerdjikova, Anna, I; Mori, Nicole; Casuto, Leah S.; McElroy, Susan L.] Univ Cincinnati, Coll Med, Dept Psychiat & Behav Neurosci, 4075 Old Western Row Rd, Mason, OH 45040 USA.
C3 University System of Ohio; University of Cincinnati
RP Guerdjikova, AI (corresponding author), Univ Cincinnati, Coll Med, Dept Psychiat & Behav Neurosci, Lindner Ctr Hope, 4075 Old Western Row Rd, Mason, OH 45040 USA.
EM anna.guerdjikova@lindnercenter.org
OI Hubsher, Dr Marshall/0000-0002-9775-0400; Hubsher,
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NR 64
TC 55
Z9 60
U1 2
U2 32
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0025-7125
EI 1557-9859
J9 MED CLIN N AM
JI Med. Clin. N. Am.
PD JUL
PY 2019
VL 103
IS 4
BP 669
EP +
DI 10.1016/j.mcna.2019.02.003
PG 13
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA ID0HO
UT WOS:000471364800006
PM 31078199
DA 2025-06-11
ER

PT J
AU Newton, RU
   Galvao, DA
AF Newton, Robert U.
   Galvao, Daniel A.
TI Exercise medicine for prostate cancer
SO EUROPEAN REVIEW OF AGING AND PHYSICAL ACTIVITY
LA English
DT Review
DE Prostate cancer; Androgen deprivation therapy; Exercise; Resistance
   training; Aerobic training; Side effects
ID ANDROGEN DEPRIVATION THERAPY; RANDOMIZED CONTROLLED-TRIAL; BONE
   METASTASES; MEN; SUPPRESSION; RESISTANCE; MUSCLE; COMPLICATIONS;
   STATISTICS; GUIDELINES
AB Since initial reports in the mid-1980s, there has been increasing interest in the application of exercise as medicine for the prevention and management of cancer. A large number of high-quality, randomised, controlled trials with cancer survivors have confirmed both aerobic and resistance exercise to be highly beneficial for improving body composition, quality of life, mental health functional capacity and reducing risk of cancer recurrence and development of other chronic diseases. Such benefits have ultimately been realised in reduced cancer mortality between 30 and 60 % in large cohort retrospective studies. Treatments for prostate cancer are increasingly effective with quite high 5- and 10-year survival rates; however, side effects of endocrine treatments in particular impact on quality of life and increased co-morbidities for the survivor. Testosterone deprivation while highly effective for controlling prostate cancer growth results in loss of muscle and bone, increased fat mass, increased incidence of metabolic syndrome, cardiovascular disease and sudden death. Exercise has been demonstrated to be a very effective medicine for counteracting all of these treatment toxicities as well as improving mental health and quality of life. Exercise has been demonstrated to be safe and well tolerated by cancer patients. Current recommendation is to complete at least 150 min of aerobic exercise and two or more sessions of resistance training per week. More specific exercise prescription is required to address particular treatment toxicities such as bone loss or obesity. This paper is a review of key research from our group into exercise medicine for prostate cancer.
C1 [Newton, Robert U.; Galvao, Daniel A.] Edith Cowan Univ, Hlth & Wellness Inst, Joondalup, WA 6027, Australia.
C3 Edith Cowan University
RP Newton, RU (corresponding author), Edith Cowan Univ, Hlth & Wellness Inst, 270 Joondalup Dr, Joondalup, WA 6027, Australia.
EM r.newton@ecu.edu.au; d.galvao@ecu.edu.au
RI Newton, Robert/A-3466-2009; Galvao, Daniel A/A-2744-2010
OI Galvao, Daniel A/0000-0002-8209-2281
CR Ahlborg HG, 2008, BONE, V43, P556, DOI 10.1016/j.bone.2008.05.003
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NR 24
TC 9
Z9 10
U1 0
U2 31
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1813-7253
EI 1861-6909
J9 EUR REV AGING PHYS A
JI Eur. Rev. Aging Phys. Act.
PD APR
PY 2013
VL 10
IS 1
BP 41
EP 45
DI 10.1007/s11556-012-0114-4
PG 5
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA 109GT
UT WOS:000316355300009
OA hybrid
DA 2025-06-11
ER

PT J
AU Hamer, M
   Batty, GD
   Kivimaki, M
AF Hamer, M.
   Batty, G. D.
   Kivimaki, M.
TI Risk of future depression in people who are obese but metabolically
   healthy: the English longitudinal study of ageing
SO MOLECULAR PSYCHIATRY
LA English
DT Article
DE depression; epidemiology; glycaemic control; inflammation; metabolic
   health; obesity
ID BODY-MASS INDEX; PSYCHOLOGICAL DISTRESS; CARDIOVASCULAR-DISEASE; WAIST
   CIRCUMFERENCE; GENERAL-POPULATION; PROSPECTIVE COHORT; MAJOR DEPRESSION;
   HEART-DISEASE; FOLLOW-UP; MEN
AB There is some evidence to suggest that obesity is a risk factor for the development of depression, although this is not a universal finding. This discordance might be ascribed to the existence of a 'healthy obese phenotype'-that is, obesity in the absence of the associated burden of cardiometabolic risk factors. We examined whether the association of obesity with depressive symptoms is dependent on the individual's metabolic health. Participants were 3851 men and women (aged 63.0 +/- 8.9 years, 45.1% men) from the English Longitudinal Study of Ageing, a prospective study of community dwelling older adults. Obesity was defined as body mass index >= 30 kgm(-2). Based on blood pressure, high-density lipoprotein cholesterol, triglycerides, glycated haemoglobin and C-reactive protein, participants were classified as 'metabolically healthy' (0 or 1 metabolic abnormality) or 'unhealthy' (>= 2 metabolic abnormalities). Depressive symptoms were assessed at baseline and at 2 years follow-up using the 8-item Centre of Epidemiological Studies Depression (CES-D) scale. Obesity prevalence was 27.5%, but 34.3% of this group was categorized as metabolically healthy at baseline. Relative to non-obese healthy participants, after adjustment for baseline CES-D score and other covariates, the metabolically unhealthy obese participants had elevated risk of depressive symptoms at follow-up (odds ratio (OR) = 1.50; 95% confidence interval (CI), 1.05-2.15), although the metabolically healthy obese did not (OR 1.38; 95% CI, 0.88-2.17). The association between obesity and risk of depressive symptoms appears to be partly dependent on metabolic health, although further work is required to confirm these findings.
C1 [Hamer, M.; Batty, G. D.; Kivimaki, M.] UCL, Dept Epidemiol & Publ Hlth, London WC1E 6BT, England.
C3 University of London; University College London
RP Hamer, M (corresponding author), UCL, Dept Epidemiol & Publ Hlth, 1-19 Torrington Pl, London WC1E 6BT, England.
EM m.hamer@ucl.ac.uk
RI Kivimaki, Mika/B-3607-2012; Batty, GD/Y-4401-2018; Hamer,
   Mark/C-1602-2008
OI Batty, George/0000-0003-1822-5753; Hamer, Mark/0000-0002-8726-7992;
   Kivimaki, Mika/0000-0002-4699-5627
FU National Institute on Aging in the United States [2RO1AG7644-01A1,
   2RO1AG017644]; Office for National Statistics; British Heart Foundation
   [RE/10/005/28296]; National Heart, Lung, and Blood Institute
   [R01HL036310-20A2]; National Institute on Aging [R01AG034454-01]; NIH,
   US; Academy of Finland; MRC [G0902037] Funding Source: UKRI
FX The data were made available through the UK Data Archive. The English
   Longitudinal Study of Ageing (ELSA) was developed by a team of
   researchers based at University College London, the Institute of Fiscal
   Studies and the National Centre for Social Research. The funding was
   provided by the National Institute on Aging in the United States (Grants
   2RO1AG7644-01A1 and 2RO1AG017644) and a consortium of UK government
   departments coordinated by the Office for National Statistics. MH was
   supported by the British Heart Foundation (RE/10/005/28296); GDB is a
   Wellcome Trust Career Development Fellow (WBS U.1300.00.006.00012.01);
   MK was supported by the National Heart, Lung, and Blood Institute
   (R01HL036310-20A2) and the National Institute on Aging (R01AG034454-01),
   NIH, US and the Academy of Finland. The funders had no role in the study
   design; in the collection, analysis and interpretation of data; in
   writing of the report; or in the decision to submit the paper for
   publication. The developers and funders of ELSA and the Archive do not
   bear any responsibility for the analyses or interpretations presented
   here.
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NR 46
TC 103
Z9 107
U1 1
U2 15
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1359-4184
EI 1476-5578
J9 MOL PSYCHIATR
JI Mol. Psychiatr.
PD SEP
PY 2012
VL 17
IS 9
BP 940
EP 945
DI 10.1038/mp.2012.30
PG 6
WC Biochemistry & Molecular Biology; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Neurosciences & Neurology; Psychiatry
GA 996DI
UT WOS:000308063900010
PM 22525487
OA Bronze, Green Accepted
DA 2025-06-11
ER

PT J
AU Muralidharan, A
   Klingaman, EA
   Prior, SJ
   Molinari, V
   Goldberg, RW
AF Muralidharan, Anjana
   Klingaman, Elizabeth A.
   Prior, Steven J.
   Molinari, Victor
   Goldberg, Richard W.
TI Medical and Psychosocial Barriers to Weight Management in Older Veterans
   With and Without Serious Mental Illness
SO PSYCHOLOGICAL SERVICES
LA English
DT Article
DE older adults; serious mental illness; veterans; obesity; weight
   management
ID LIFE-STYLE INTERVENTION; NURSING-HOME ADMISSION; PHYSICAL-ACTIVITY;
   HEALTH; ADULTS; OBESITY; SCHIZOPHRENIA; COMORBIDITY; PREVALENCE;
   OUTCOMES
AB Older adults with serious mental illness (SMI) are an understudied population with complex care needs and high rates of obesity/overweight. Little is known about the experiences of older adults with SMI with weight management. The present study is an observational study of veterans ages 55 and over with a body mass index in the overweight or obese range, comparing Veterans with schizophrenia or bipolar disorder (n = 9044) to their same-age peers with no mental health disorders (n = 71156), on their responses to a questionnaire assessment of medical and psychosocial factors related to weight management. Responses to the questionnaire between August, 2005 and May, 2013 were used to examine the following: demographics, clinical characteristics, medical barriers to weight management, current weight loss plan, reliability of social support, reasons for being overweight, and weight loss barriers. Physical health concerns were highly prevalent in both groups. Veterans in the SMI group endorsed more medical issues and were significantly more likely to endorse experiences that indicated that their medical conditions were poorly controlled (e.g., shortness of breath). Veterans in the SMI group were more likely to endorse many barriers to healthy eating and physical activity, across medical, psychological, social, and environmental domains. Even within a sample at medically high-risk for complications related to obesity and metabolic syndrome, older veterans with SMI and overweight/obesity experience more challenges with weight management than their same-age peers with overweight/obesity and no mental health disorders. Weight management interventions for this population should take a multifaceted approach.
C1 [Muralidharan, Anjana; Klingaman, Elizabeth A.; Goldberg, Richard W.] Vet Affairs Capitol Healthcare Network Mental Ill, Baltimore, MD USA.
   [Muralidharan, Anjana; Klingaman, Elizabeth A.] Univ Maryland, Dept Psychiat, College Pk, MD 20742 USA.
   [Prior, Steven J.] Univ Maryland, Div Gerontol & Geriatr Med, Sch Med & Vet Affairs Capitol Hlth Care Network V, College Pk, MD 20742 USA.
   [Molinari, Victor] Univ S Florida, Sch Aging Studies, Tampa, FL 33620 USA.
   [Goldberg, Richard W.] Univ Maryland, Sch Medicine, Dept Psychiat, College Pk, MD 20742 USA.
C3 University System of Maryland; University of Maryland College Park;
   University System of Maryland; University of Maryland College Park;
   State University System of Florida; University of South Florida;
   University System of Maryland; University of Maryland College Park
RP Muralidharan, A (corresponding author), Vet Affairs Capitol Hlth Care Network VISN 5 Ment, Baltimore VA Med Ctr, 10 North Greene St,Annex Suite 720, Baltimore, MD 21201 USA.
EM Anjana.Muralidharan2@va.gov
RI Prior, Steven/AAC-8232-2020; Molinari, Victor/AGX-1667-2022
OI Muralidharan, Anjana/0000-0002-9155-5524
FU Department of Veterans Affairs Office of Academic Affiliations Advanced
   Fellowship Program in Mental Illness Research and Treatment
FX This research is supported by the Department of Veterans Affairs Office
   of Academic Affiliations Advanced Fellowship Program in Mental Illness
   Research and Treatment. It is the result of work supported with
   resources and the use of facilities at the VA Capitol Health Care
   Network (VISN 5) MIRECC. This article reflects the authors' personal
   views and in no way represents the official view of the Department of
   Veterans Affairs of the U.S. Government.
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NR 36
TC 7
Z9 9
U1 0
U2 7
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 1541-1559
EI 1939-148X
J9 PSYCHOL SERV
JI Psychol. Serv.
PD NOV
PY 2016
VL 13
IS 4
BP 419
EP 427
DI 10.1037/ser0000088
PG 9
WC Psychology, Clinical
WE Social Science Citation Index (SSCI)
SC Psychology
GA EB3EE
UT WOS:000387244600011
PM 27441416
OA hybrid
DA 2025-06-11
ER

PT J
AU Aguilera, J
   Jeon, S
   Chavez, M
   Ibarra-Mejia, G
   Ferreira-Pinto, J
   Whigham, LD
   Li, WW
AF Aguilera, Juan
   Jeon, Soyoung
   Chavez, Mayra
   Ibarra-Mejia, Gabriel
   Ferreira-Pinto, Joao
   Whigham, Leah D.
   Li, Wen-Whai
TI Short-Term Associations of Traffic-Related Air Pollution with
   Cardiorespiratory Outcomes Among Low-Income Residents from a US-Mexico
   Border Community
SO ATMOSPHERE
LA English
DT Article
DE air quality; traffic-related air pollution (TRAP); obesity; metabolic
   syndrome (MetS); respiratory disease; cardiovascular disease; Hispanics;
   border health; low income; public and environmental health
ID LUNG-FUNCTION; DIABETES-MELLITUS; EL-PASO; EXPOSURE; INFLAMMATION;
   POLLUTANTS; CHOLESTEROL; INSULIN; OBESITY; METRICS
AB Exposure to traffic-related air pollution is not merely linked to respiratory health issues but also poses significant risks to cardiovascular well-being. Individuals from lower-income communities residing in high-pollution zones are particularly vulnerable to adverse cardiorespiratory health impacts. Pollutants such as fine particulate matter (PM2.5 and PM10), nitrogen dioxide (NO2), and ozone (O3) are recognized as a leading, yet preventable, contributor to cardiorespiratory diseases. Although research has extensively explored the short-term impact of these pollutants on respiratory health, the immediate effects on cardiovascular outcomes require further study. We explored associations of traffic-related air pollutants with airway inflammation, lung function, and cardiovascular health outcomes (metabolic syndrome [MetS]) collected from a sample of low-income participants (N = 662) from a US-Mexico border county. Airway inflammation was measured using exhaled nitric oxide tests (eNO), while lung function parameters were measured by spirometry. MetS risk factors (waist circumference, blood pressure, triglycerides, HDL, and fasting blood glucose) were also measured. While spirometry measures were negatively associated with air pollutants (p < 0.05), no associations were noted for eNO. We also found positive associations in linear and logistic models between air pollutants and obesity (BMI: p < 0.04; waist: p < 0.03), fasting blood glucose (p < 0.03), and metabolic syndrome (p < 0.04). These findings reaffirm the immediate adverse effects of air pollution on respiratory function and shed light on its broader metabolic consequences. Environmental and neighborhood conditions could potentially influence the associations with obesity. At the same time, the links between fasting glucose and metabolic syndrome might indicate underlying oxidative stress and systemic inflammation.
C1 [Aguilera, Juan] UTHlth Houston, Ctr Community Hlth Impact, Sch Publ Hlth, El Paso, TX 79905 USA.
   [Jeon, Soyoung] New Mexico State Univ, Dept Econ Appl Stat & Int Business, Las Cruces, NM 88003 USA.
   [Chavez, Mayra; Li, Wen-Whai] Univ Texas El Paso, Dept Civil Engn, El Paso, TX 79968 USA.
   [Ibarra-Mejia, Gabriel] Univ Texas El Paso, Dept Publ Hlth Sci, El Paso, TX 79968 USA.
   [Ferreira-Pinto, Joao] Univ Texas El Paso, Coll Hlth Sci, El Paso, TX 79968 USA.
   [Whigham, Leah D.] Univ Texas Austin, Dept Nutr Sci, Austin, TX 78712 USA.
C3 New Mexico State University; University of Texas System; University of
   Texas El Paso; University of Texas System; University of Texas El Paso;
   University of Texas System; University of Texas El Paso; University of
   Texas System; University of Texas Austin
RP Aguilera, J (corresponding author), UTHlth Houston, Ctr Community Hlth Impact, Sch Publ Hlth, El Paso, TX 79905 USA.
EM juan.aguilera@uth.tmc.edu
RI ; Aguilera, Juan/GPT-0890-2022
OI Ibarra-Mejia, Gabriel/0000-0003-4312-6319; Aguilera,
   Juan/0000-0002-6451-0662; Jeon, Soyoung/0000-0003-3679-3615; Whigham,
   Leah/0000-0002-5376-8967
FU U.S. Department of Transportation through the Center for Advancing
   Research in Transportation Emissions, Energy, and Health (CARTEEH); 
   [69A3551747128]
FX This study was supported by grant 69A3551747128 from the U.S. Department
   of Transportation through the Center for Advancing Research in
   Transportation Emissions, Energy, and Health (CARTEEH).
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NR 53
TC 0
Z9 0
U1 1
U2 1
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2073-4433
J9 ATMOSPHERE-BASEL
JI Atmosphere
PD FEB
PY 2025
VL 16
IS 2
AR 153
DI 10.3390/atmos16020153
PG 20
WC Environmental Sciences; Meteorology & Atmospheric Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences
GA Y2S6E
UT WOS:001430689400001
OA gold
DA 2025-06-11
ER

PT J
AU Alcala-Diaz, JF
   Delgado-Lista, J
   Perez-Martinez, P
   Garcia-Rios, A
   Marin, C
   Quintana-Navarro, GM
   Gomez-Luna, P
   Camargo, A
   Almaden, Y
   Caballero, J
   Tinahones, FJ
   Ordovas, JM
   Perez-Jimenez, F
   Lopez-Miranda, J
AF Alcala-Diaz, Juan F.
   Delgado-Lista, Javier
   Perez-Martinez, Pablo
   Garcia-Rios, Antonio
   Marin, Carmen
   Quintana-Navarro, Gracia M.
   Gomez-Luna, Purificacion
   Camargo, Antonio
   Almaden, Yolanda
   Caballero, Javier
   Tinahones, Francisco J.
   Ordovas, Jose M.
   Perez-Jimenez, Francisco
   Lopez-Miranda, Jose
TI Hypertriglyceridemia Influences the Degree of Postprandial Lipemic
   Response in Patients with Metabolic Syndrome and Coronary Artery
   Disease: From the Cordioprev Study
SO PLOS ONE
LA English
DT Article
ID CARDIOVASCULAR-DISEASE; NONFASTING TRIGLYCERIDES; OXIDATIVE STRESS;
   LIPID-METABOLISM; HEART-DISEASE; RISK; MEN; ATHEROSCLEROSIS;
   METAANALYSIS; DIETARY
AB Objective: To determine whether metabolic syndrome traits influence the postprandial lipemia response of coronary patients, and whether this influence depends on the number of MetS criteria.
   Materials and Methods: 1002 coronary artery disease patients from the CORDIOPREV study were submitted to an oral fat load test meal with 0.7 g fat/ kg body weight (12% saturated fatty acids, 10% polyunsaturated fatty acids, 43% monounsaturated fatty acids), 10% protein and 25% carbohydrates. Serial blood test analyzing lipid fractions were drawn at 0, 1, 2, 3 and 4 hours during the postprandial state. Total and incremental area under the curves of the different postprandial parameters were calculated following the trapezoid rule to assess the magnitude of change during the postprandial state
   Results: Postprandial lipemia response was directly related to the presence of metabolic syndrome. We found a positive association between the number of metabolic syndrome criteria and the response of postprandial plasma triglycerides (p< 0.001), area under the curve of triglycerides (p<0.001) and incremental area under the curve of triglycerides (p<0.001). However, the influence of them on postprandial triglycerides remained statistically significant only in those patients without basal hypertriglyceridemia. Interestingly, in stepwise multiple linear regression analysis with the AUC of triglycerides as the dependent variable, only fasting triglycerides, fasting glucose and waist circumference appeared as significant independent (P<0.05) contributors. The multiple lineal regression (R) was 0.77, and fasting triglycerides showed the greatest effect on AUC of triglycerides with a standardized coefficient of 0.75.
   Conclusions: Fasting triglycerides are the major contributors to the postprandial triglycerides levels. MetS influences the postprandial response of lipids in patients with coronary heart disease, particularly in non-hypertriglyceridemic patients.
C1 [Alcala-Diaz, Juan F.; Delgado-Lista, Javier; Perez-Martinez, Pablo; Garcia-Rios, Antonio; Marin, Carmen; Quintana-Navarro, Gracia M.; Gomez-Luna, Purificacion; Camargo, Antonio; Almaden, Yolanda; Perez-Jimenez, Francisco; Lopez-Miranda, Jose] Univ Cordoba, Hosp Univ Reina Sofia, Inst Maimonides Invest Biomed Cordoba IMIBIC, Unidad Lipidos & Arteriosclerosis,Dept Med, Cordoba, Spain.
   [Alcala-Diaz, Juan F.; Delgado-Lista, Javier; Perez-Martinez, Pablo; Garcia-Rios, Antonio; Marin, Carmen; Gomez-Luna, Purificacion; Camargo, Antonio; Almaden, Yolanda; Perez-Jimenez, Francisco; Lopez-Miranda, Jose] Inst Salud Carlos III, Ctr Invest Biomed Red Fisiopatol Obesidad & Nutr, Madrid, Spain.
   [Caballero, Javier] Hosp Univ Reina Sofia, Dept Anal Clin, Cordoba, Spain.
   [Tinahones, Francisco J.] Inst Salud Carlos III, CIBEROBN, Hosp Virgen Victoria, Malaga, Spain.
   [Ordovas, Jose M.] Tufts Univ, Nutr & Genom Lab, Jean Mayer US Dept Agr, Human Nutr Res Ctr Aging, Boston, MA 02111 USA.
   [Ordovas, Jose M.] Inst Madrileno Estudios Avanzados Alimentac IMDEA, Madrid, Spain.
C3 Universidad de Cordoba; CIBER - Centro de Investigacion Biomedica en
   Red; CIBEROBN; Instituto de Salud Carlos III; CIBER - Centro de
   Investigacion Biomedica en Red; CIBEROBN; Instituto de Salud Carlos III;
   United States Department of Agriculture (USDA); Tufts University
RP Lopez-Miranda, J (corresponding author), Univ Cordoba, Hosp Univ Reina Sofia, Inst Maimonides Invest Biomed Cordoba IMIBIC, Unidad Lipidos & Arteriosclerosis,Dept Med, Cordoba, Spain.
EM jlopezmir@uco.es
RI Delgado-Lista, Javier/KAM-7412-2024; Lopez-Miranda, Jose/Y-8306-2019;
   Marin Hinojosa, Carmen/AFO-1294-2022; Jimenez, Francisco/AAJ-9559-2021;
   Tejada, Silvia/L-7297-2014; Alcala-Diaz, Juan/Q-4455-2019; Tinahones,
   Francisco/AAB-2882-2020; Caballero-Villarraso, Javier/AAC-3434-2019;
   Camargo Garcia, Antonio/G-9720-2015; Ordovas, Jose/B-8727-2013; Perez
   Martinez, Pablo/AEL-6176-2022
OI Lopez-Miranda, Jose/0000-0002-8844-0718; Perez-Jimenez,
   Francisco/0000-0001-7499-7681; QUINTANA-NAVARRO, GRACIA
   MARIA/0000-0003-4413-4062; Alcala-Diaz, Juan
   Francisco/0000-0002-4572-3611; Delgado Lista, Francisco
   Javier/0000-0002-2982-2716; Caballero-Villarraso,
   Javier/0000-0003-0571-5147; Tinahones, Francisco J/0000-0001-6871-4403;
   Camargo Garcia, Antonio/0000-0002-0415-4184; Ordovas,
   Jose/0000-0002-7581-5680; Perez Martinez, Pablo/0000-0001-7716-8117;
   Perez Jimenez, Francisco/0000-0001-9808-1280
FU Fundacion Patrimonio Comunal Olivarero; Junta de Andalucia (Consejeria
   de Salud, Consejeria de Agricultura y Pesca; Consejeria de Innovacion,
   Ciencia y Empresa); Diputaciones de Jaen y Cordoba; Centro de Excelencia
   en Investigacion sobre Aceite de Oliva y Salud; Ministerio de Ciencia e
   Innovacion [AGL2009-122270, FIS PI10/01041, PI10/02412]; Ministerio de
   Economia y Competitividad [AGL2012/39615]; Consejeria de Economia;
   Proyectos de Investigacion de Excelencia; Junta de Andalucia [AGR922,
   PI0193/09]; Consejeria de Salud; Consejeria de Innovacion Ciencia y
   Empresa [CVI-7450]; ISCIII (Programa Rio-Hortega); Nicolas Monardes
   Programme; Consejeria de Salud-SAS (Junta de Andalucia);  [0118/08]; 
   [PI-0252/09];  [PI-0058/10]
FX The CORDIOPREV study is supported from Fundacion Patrimonio Comunal
   Olivarero, Junta de Andalucia (Consejeria de Salud, Consejeria de
   Agricultura y Pesca, Consejeria de Innovacion, Ciencia y Empresa),
   Diputaciones de Jaen y Cordoba, Centro de Excelencia en Investigacion
   sobre Aceite de Oliva y Salud and Ministerio de Medio Ambiente, Medio
   Rural y Marino, Gobierno de Espana Also supported in part by research
   grants from the Ministerio de Ciencia e Innovacion (AGL2009-122270 to J
   L-M, FIS PI10/01041 to P P-M, PI10/02412 to F P-J); Ministerio de
   Economia y Competitividad (AGL2012/39615 to J L-M); Consejeria de
   Economia, Innovacion y Ciencia, Proyectos de Investigacion de
   Excelencia, Junta de Andalucia (AGR922 to F P-J); Consejeria de Salud,
   Junta de Andalucia (PI0193/09 to J L-M), 0118/08 to F F-J, PI-0252/09 to
   J D-L, and PI-0058/10 to P P-M; Consejeria de Innovacion Ciencia y
   Empresa (CVI-7450 to J L-M. JF Alcala-Diaz is supported by a research
   contract of ISCIII (Programa Rio-Hortega). Y Almaden is a senior
   researcher supported by the Nicolas Monardes Programme, Consejeria de
   Salud-SAS (Junta de Andalucia). The CIBEROBN is an initiative of the
   Instituto de Salud Carlos III, Madrid, Spain. The funders had no role in
   study design, data collection and analysis, decision to publish, or
   preparation of the manuscript.
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NR 40
TC 32
Z9 34
U1 0
U2 17
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAY 6
PY 2014
VL 9
IS 5
AR e96297
DI 10.1371/journal.pone.0096297
PG 9
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA AJ9KS
UT WOS:000338029800050
PM 24802225
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Depp, C
   Ojeda, VD
   Mastin, W
   Unützer, J
   Gilmer, TP
AF Depp, Colin
   Ojeda, Victoria D.
   Mastin, William
   Unuetzer, Juergen
   Gilmer, Todd P.
TI Trends in use of antipsychotics and mood stabilizers among Medicaid
   beneficiaries with bipolar disorder, 2001-2004
SO PSYCHIATRIC SERVICES
LA English
DT Article
ID METABOLIC SYNDROME; STEP-BD; CARE; SCHIZOPHRENIA; PATTERNS; COSTS
AB Objective: This study examined longitudinal trends in the use of mood stabilizers and antipsychotics for treatment of bipolar disorder in a large public mental health system and whether trends differed by age, gender, and race-ethnicity. Methods: Data were from Medicaid beneficiaries with bipolar disorder receiving services in the San Diego County public mental health system from 2001 to 2004. For each year the proportion of clients receiving any pharmacotherapy and the proportion receiving antipsychotics alone, mood stabilizers alone, or antipsychotics plus mood stabilizers were determined. Pharmacotherapy use was examined by age, gender, and race-ethnicity. Results: A total of 1,473 clients were identified who were continuously enrolled in Medicaid during the four years. Seventy-five percent received mood stabilizers or antipsychotics. Of this group, 33% received antipsychotics alone, 23% mood stabilizers alone, and 44% both antipsychotics and mood stabilizers. The percentage receiving mood stabilizers or antipsychotics increased significantly, from 71% in 2001 to 77% in 2004, primarily because of increased use among women. Use of mood stabilizers alone declined from 25% to 20%, and use of antipsychotics alone increased from 32% to 36%. African Americans and Latinos were less likely than non-Latino whites to receive mood stabilizers or antipsychotics; this pattern was stable over time. Conclusions: Antipsychotics were prescribed for a larger percentage of clients than mood stabilizers. Persons from ethnic minority groups were less likely to receive either medication type. Research is needed to examine factors affecting pharmacotherapy in bipolar disorder and mechanisms underlying racial-ethnic disparities in pharmacotherapy, including their persistence over time.
C1 [Ojeda, Victoria D.; Gilmer, Todd P.] Univ Calif San Diego, Dept Family & Prevent Med, La Jolla, CA 92093 USA.
   [Depp, Colin] Univ Calif San Diego, Sam & Rose Stein Inst Res Aging, La Jolla, CA 92093 USA.
   [Mastin, William] Calif Dept Vet Affairs, Sacramento, CA USA.
   [Unuetzer, Juergen] Univ Washington, Dept Psychiat, Seattle, WA 98195 USA.
C3 University of California System; University of California San Diego;
   University of California System; University of California San Diego;
   University of Washington; University of Washington Seattle
RP Gilmer, TP (corresponding author), Univ Calif San Diego, Dept Family & Prevent Med, 9500 Gilman Dr 0622, La Jolla, CA 92093 USA.
EM tgilmer@ucsd.edu
RI Unutzer, Jurgen/N-4048-2018; depp, colin/D-1264-2009
OI Depp, Colin/0000-0002-1841-6229; Unutzer, Jurgen/0009-0005-6585-7835
FU National Institute of Mental Health [MH-077225, P30-MH-066248]; National
   Institute on Drug Abuse [3-R01DA-019829-S1]
FX This work was supported in part by grants MH-077225 and P30-MH-066248
   from the National Institute of Mental Health and grant 3-R01DA-019829-S1
   from the National Institute on Drug Abuse. The authors gratefully
   acknowledge Adult and Older Adult Mental Health Services and the County
   of San Diego Health and Human Services Agency for access to the
   management information systems. The authors report no competing
   interests.
CR [Anonymous], 2002, PRACT GUID TREATM PA
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NR 24
TC 37
Z9 40
U1 0
U2 5
PU AMER PSYCHIATRIC PUBLISHING, INC
PI ARLINGTON
PA 1000 WILSON BOULEVARD, STE 1825, ARLINGTON, VA 22209-3901 USA
SN 1075-2730
J9 PSYCHIAT SERV
JI Psychiatr. Serv.
PD OCT
PY 2008
VL 59
IS 10
BP 1169
EP 1174
DI 10.1176/appi.ps.59.10.1169
PG 6
WC Health Policy & Services; Public, Environmental & Occupational Health;
   Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services; Public, Environmental & Occupational
   Health; Psychiatry
GA 355IV
UT WOS:000259703500015
PM 18832503
DA 2025-06-11
ER

PT J
AU Aouira, N
   Khan, S
   Heussler, H
   Haywood, A
   Karaksha, A
   Bor, W
AF Aouira, Nisreen
   Khan, Sohil
   Heussler, Helen
   Haywood, Alison
   Karaksha, Abdullah
   Bor, William
TI Practitioners' Perspective on Metabolic Monitoring of Second-Generation
   Antipsychotics: Existing Gaps in Knowledge, Barriers to Monitoring, and
   Strategies
SO JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY
LA English
DT Article
DE psychiatrists; perspective; barriers; strategies; antipsychotics; youth
ID QUALITY-OF-LIFE; HEALTH; SCHIZOPHRENIA; CARE; PSYCHIATRISTS;
   MEDICATIONS; CHILDREN; RECOMMENDATIONS; IMPLEMENTATION; PREDICTORS
AB Introduction: Prescription of second-generation antipsychotics (SGAs) in youth is rapidly increasing globally and in Australia. Lack of timely metabolic monitoring for potential adverse effects puts youth at greater risk for lifelong adverse health impact. Metabolic monitoring is recommended as best practice to prevent and/or manage SGA-induced weight gain/metabolic syndrome. The adherence to clinical guidelines remains suboptimal. It is crucial to gauge insight to challenges and strategies from the perspective of prescribers and to recommend strategies in promoting quality use of SGAs and adherence to pharmacovigilance standards.Methods: Psychiatrists participated through semistructured interviews within the community mental health clinics in the Queensland State of Australia. The interviews focused on barriers to monitoring and strategies to enhance rate of monitoring with key focus on practical strategies for future implications in community setting.Results: Ten participants completed the interviews. Barriers were specified such as lack of adequate resources to conduct monitoring, carers' disengagement in their youth's treatments, and patients' refusal to undergo blood tests. Strategies to enhance metabolic monitoring heavily relied on organizational support, provision of training, and education opportunities.Conclusions: Clinical recommendations require mental health providers to facilitate conduction of metabolic monitoring among youth prescribed SGA/s. However, they are not provided with enough support and there are challenges that prevent such care. It is crucial to understand the challenges in managing a complex and vulnerable patient cohort. This research has thrown light on these key aspects of existing gap between best practice standards and clinical practice in youth prescribed SGAs.
C1 [Aouira, Nisreen; Khan, Sohil; Haywood, Alison; Karaksha, Abdullah] Griffith Univ, Menzies Hlth Inst Queensland, Sch Pharm & Med Sci, Gold Coast, Qld, Australia.
   [Khan, Sohil; Heussler, Helen; Haywood, Alison; Bor, William] Univ Queensland, Mater Res Inst, Brisbane, Qld, Australia.
   [Khan, Sohil] Manipal Acad Higher Educ, Prasanna Inst Publ Hlth, Manipal, India.
   [Khan, Sohil] Manipal Acad Higher Educ, Manipal Coll Pharmaceut Sci, Manipal, India.
   [Heussler, Helen; Bor, William] Childrens Hlth Queensland Hosp & Hlth Serv, South Brisbane, Qld, Australia.
   [Bor, William] Queensland Hlth, Ctr Childrens Hlth Res, Child & Youth Mental Hlth Serv, Brisbane, Qld, Australia.
   [Aouira, Nisreen] Griffith Univ, Menzies Hlth Inst Queensland, Sch Pharm & Med Sci, Gold Coast Campus, Gold Coast, Qld 4222, Australia.
C3 Menzies Health Institute Queensland; Griffith University; Griffith
   University - Gold Coast Campus; Mater Research; University of
   Queensland; Manipal Academy of Higher Education (MAHE); Manipal Academy
   of Higher Education (MAHE); Childrens Health Queensland Hospital &
   Health Service; Queensland Health; Menzies Health Institute Queensland;
   Griffith University; Griffith University - Gold Coast Campus
RP Aouira, N (corresponding author), Griffith Univ, Menzies Hlth Inst Queensland, Sch Pharm & Med Sci, Gold Coast Campus, Gold Coast, Qld 4222, Australia.
EM n.aouira@griffith.edu.au
RI Bor, William/J-2215-2015
OI Haywood, Alison/0000-0002-5354-8868; Aouira, Nisreen/0000-0001-9297-6737
CR Australian Institute of Health and Welfare, 2018, Data tables: chronic respiratory conditions mortality data
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NR 47
TC 4
Z9 5
U1 0
U2 4
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1044-5463
EI 1557-8992
J9 J CHILD ADOL PSYCHOP
JI J. Child Adolesc. Psychopharmacol.
PD JUN 1
PY 2022
VL 32
IS 5
BP 296
EP 303
DI 10.1089/cap.2022.0021
EA JUN 2022
PG 8
WC Pediatrics; Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics; Pharmacology & Pharmacy; Psychiatry
GA 2D3ME
UT WOS:000807287700001
PM 35666251
DA 2025-06-11
ER

PT J
AU Guerdjikova, AI
   Mori, N
   Casuto, LS
   McElroy, SL
AF Guerdjikova, Anna I.
   Mori, Nicole
   Casuto, Leah S.
   McElroy, Susan L.
TI Binge Eating Disorder
SO PSYCHIATRIC CLINICS OF NORTH AMERICA
LA English
DT Article
DE Binge eating disorder; Female binge eating; Treatment; Gender; Sex
   differences; Eating dysregulation
ID COGNITIVE-BEHAVIORAL THERAPY; RANDOMIZED CONTROLLED-TRIAL; PRIMARY-CARE;
   GENDER-DIFFERENCES; MENSTRUAL-CYCLE; BULIMIA-NERVOSA; WEIGHT-LOSS;
   METABOLIC SYNDROME; OVARIAN HORMONES; ADVERSE OUTCOMES
AB Binge eating disorder (BED) is the most common eating disorder and an important public health problem. Lifetime prevalence of BED in the United States is 2.6%. In contrast to other eating disorders, the female to male ratio in BED is more balanced. BED co-occurs with a plethora of psychiatric disorders, most commonly mood and anxiety disorders. BED is also associated with obesity and its numerous complications. Although BED is similar in men and women in presentation and treatment outcomes, there are some key neurobiological differences that should be taken in consideration when personalizing treatment.
C1 [Guerdjikova, Anna I.; Mori, Nicole; Casuto, Leah S.; McElroy, Susan L.] Lindner Ctr HOPE, 4075 Old Western Row Rd, Mason, OH 45040 USA.
   [Guerdjikova, Anna I.; Mori, Nicole; Casuto, Leah S.; McElroy, Susan L.] Univ Cincinnati, Coll Med, Dept Psychiat & Behav Neurosci, 4075 Old Western Row Rd, Mason, OH 45040 USA.
C3 University System of Ohio; University of Cincinnati
RP Guerdjikova, AI (corresponding author), Univ Cincinnati, Coll Med, Dept Psychiat & Behav Neurosci, Lindner Ctr HOPE, 4075 Old Western Row Rd, Mason, OH 45040 USA.
EM anna.guerdjikova@lindnercenter.org
FU Alkermes; Forest; Marriott Foundation; National Institute of Mental
   Health; Naurex; Orexigen Therapeutics, Inc; Shire; Sunovion; Takeda
   Pharmaceutical Company Ltd.; Johnson Johnson
FX Dr L.S. Casuto and Mrs N. Mori have no conflicts of interest to
   disclose. Dr S. L. McElroy is a consultant to or member of the
   scientific advisory boards of Bracket, F. Hoffmann-La Roche Ltd,
   MedAvante, Myriad, Naurex, Novo Nordisk, Shire, and Sunovion. She is a
   principal or coinvestigator on studies sponsored by the Alkermes,
   Forest, Marriott Foundation, National Institute of Mental Health,
   Naurex, Orexigen Therapeutics, Inc, Shire, Sunovion, and Takeda
   Pharmaceutical Company Ltd. She is also an inventor on US Patent No.
   6,323,236 B2, use of sulfamate derivatives for treating impulse control
   disorders, and along with the patent's assignee, University of
   Cincinnati, Cincinnati, Ohio, has received payments from Johnson &
   Johnson, which has exclusive rights under the patent. Dr A.I.
   Guerdjikova is employed by the University of Cincinnati College of
   Medicine and is a consultant for Bracket.
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NR 62
TC 39
Z9 46
U1 6
U2 74
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0193-953X
EI 1558-3147
J9 PSYCHIAT CLIN N AM
JI Psychiatr. Clin. North Amer.
PD JUN
PY 2017
VL 40
IS 2
BP 255
EP +
DI 10.1016/j.psc.2017.01.003
PG 13
WC Psychiatry
WE Social Science Citation Index (SSCI)
SC Psychiatry
GA EW8PW
UT WOS:000402781600006
PM 28477651
DA 2025-06-11
ER

PT J
AU Sugawara, N
   Yasui-Furukori, N
   Sato, Y
   Saito, M
   Furukori, H
   Nakagami, T
   Kudo, S
   Kaneko, S
AF Sugawara, Norio
   Yasui-Furukori, Norio
   Sato, Yasushi
   Saito, Manabu
   Furukori, Hanako
   Nakagami, Taku
   Kudo, Shuhei
   Kaneko, Sunao
TI Body mass index and quality of life among outpatients with schizophrenia
   in Japan
SO BMC PSYCHIATRY
LA English
DT Article
DE Body mass index; Quality of life; Schizophrenia; Japan
ID WEIGHT-GAIN; PHYSICAL-ACTIVITY; METABOLIC SYNDROME; OBESITY; HEALTH;
   POPULATION; PREVALENCE; IMPACT; INTERVENTIONS; INDIVIDUALS
AB Background: Obesity is becoming more prevalent and thus growing as a public health concern in patients with schizophrenia. This investigation evaluated the relationship between body weight and the self-reported quality of life (QOL) of Japanese patients with schizophrenia.
   Methods: We recruited outpatients (n=225) aged 42.5 +/- 12.8 (mean +/- SD) years with a DSM-IV diagnosis of schizophrenia who were admitted to psychiatric hospitals. This study used a cross-sectional design. The assessments included an interview to obtain sociodemographic data, the second version of the Short Form Health Survey (SF-36v2), the 10-item version of the Drug Attitude Inventory (DAI-10), the Clinical Global Impression-Severity (CGI-S) and height and weight measurements. SF-36v2 subscores were examined for differences based on the following body mass index (BMI) categories: healthy weight (BMI < 24.9), overweight (BMI 25-29.9) and obese (BMI > 30). A multiple regression analysis was employed to assess the relationship between these BMI categories and QOL outcomes.
   Results: The overall prevalence of obesity in our sample was 16.4%. A multiple regression model revealed that age, gender, DAI-10 scores, CGI-S scores, social functioning, role emotional functioning, mental health, and Mental Composite Summary (MCS) score were significantly and positively associated with overweight status. Physical functioning, general health, role emotional functioning, mental health, and a physical composite summary (PCS) score were significantly and negatively associated with obesity.
   Conclusions: The burden of obesity is both a physical and a mental problem. An obesity intervention program for patients with schizophrenia may improve health-related QOL in patients with schizophrenia.
C1 [Sugawara, Norio; Yasui-Furukori, Norio; Sato, Yasushi; Saito, Manabu; Kudo, Shuhei; Kaneko, Sunao] Hirosaki Univ, Sch Med, Dept Neuropsychiat, Hirosaki, Aomori 036, Japan.
   [Sato, Yasushi] Hirosaki Aiseikai Hosp, Dept Psychiat, Hirosaki, Aomori, Japan.
   [Furukori, Hanako] Kuroishi Akebono Hosp, Dept Psychiat, Kuroishi, Aomori, Japan.
   [Nakagami, Taku] Odate Municipal Gen Hosp, Dept Psychiat, Odate, Japan.
C3 Hirosaki University
RP Sugawara, N (corresponding author), Hirosaki Univ, Sch Med, Dept Neuropsychiat, Hirosaki, Aomori 036, Japan.
EM nsuga3@yahoo.co.jp
FU Hirosaki Research Institute for the neurosciences
FX The authors would like to thank all coworkers for their skilful
   contributions to the data collection and management. This work was
   partly supported by a grant from Hirosaki Research Institute for the
   neurosciences.
CR Albright CL, 2008, OBESITY, V16, P1138, DOI 10.1038/oby.2008.31
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   Allison DB, 2003, PSYCHIAT SERV, V54, P565, DOI 10.1176/appi.ps.54.4.565
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   Caemmerer J, 2012, SCHIZOPHR RES, V140, P159, DOI 10.1016/j.schres.2012.03.017
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NR 29
TC 21
Z9 22
U1 0
U2 8
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-244X
J9 BMC PSYCHIATRY
JI BMC Psychiatry
PD APR 9
PY 2013
VL 13
AR 108
DI 10.1186/1471-244X-13-108
PG 6
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 141BG
UT WOS:000318699700001
PM 23570345
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU McMahen, C
   Wright, K
   Stanton, R
   Lederman, O
   Rosenbaum, S
   McKeon, G
   Furzer, B
AF McMahen, Caleb
   Wright, Kemi
   Stanton, Robert
   Lederman, Oscar
   Rosenbaum, Simon
   McKeon, Grace
   Furzer, Bonnie
TI Outcome assessments used in studies examining the effect of prescribed
   exercise interventions for people living with severe mental illness, a
   scoping review
SO MENTAL HEALTH AND PHYSICAL ACTIVITY
LA English
DT Review
DE Severe mental illness; Exercise; Assessment; Physical health; Mental
   health
ID MAJOR DEPRESSIVE DISORDER; WEIGHT-LOSS INTERVENTION; QUALITY-OF-LIFE;
   METABOLIC SYNDROME; PHYSICAL-ACTIVITY; PSYCHOTIC DISORDERS; AEROBIC
   EXERCISE; CARDIORESPIRATORY FITNESS; WAIST CIRCUMFERENCE; HEALTH
AB Background: Exercise interventions are increasingly incorporated in the management of severe mental illness; however, best practice screening and outcome monitoring for this unique population are yet to be established. This review aims to explore assessment measures reported in publications of exercise interventions in severe mental illness.
   Methods: A scoping review was implemented with a structured search of Embase, PubMed, Medline, PsychINFO, Scopus, and SportDiscus using terms related to severe mental illness, exercise, and health. Studies were included if they incorporated an exercise intervention for people with severe mental illness and measured physical and/or mental health outcomes. Studies were analysed for population, assessment measures, and methodological quality.
   Results: 1832 studies were identified and following screening and full text review 38 studies involving 2854 participants were included for analysis, primarily psychotic (n = 13), depressive disorder (n = 9) and mixed severe mental illness populations (n = 13). The most frequently reported health domains and assessment measures used included body composition (weight and body mass index), symptom severity, cardiorespiratory fitness (volume of oxygen consumption), cardiometabolic health (blood pressure and metabolic blood sampling), and quality of life. Methodological quality varied with 13 determined as good, 12 fair, and 13 poor.
   Conclusion: The review identified domains and assessment tools frequently reported in the exercise and severe mental illness literature. However, given the heterogeneity and scarcity of the research, along with lack of reporting of sufficient detail, best-practice clinical recommendations are still limited. There remains a need to establish best practice assessment and monitoring procedures within exercise interventions in severe mental illness.
C1 [McMahen, Caleb; Wright, Kemi; Furzer, Bonnie] Univ Western Australia, Sch Human Sci Exercise & Sport Sci, Nedlands, WA, Australia.
   [Wright, Kemi; Furzer, Bonnie] South Metropolitan Hlth Serv, Fremantle Hosp Mental Hlth Serv, Perth, WA, Australia.
   [Stanton, Robert] Appleton Inst, Cluster Resilience & Wellbeing, Wayville, SA, Australia.
   [Stanton, Robert] Cent Queensland Univ, Sch Hlth Med & Appl Sci, Rockhampton, Qld, Australia.
   [Lederman, Oscar] South Eastern Sydney Local Hlth Dist, Keeping Body Mind Program, Sydney, NSW, Australia.
   [Lederman, Oscar] Univ New South Wales Sydney, Sch Hlth Sci, Sydney, NSW, Australia.
   [Rosenbaum, Simon; McKeon, Grace] Univ New South Wales Sydney, Sch Psychiat, Sydney, NSW, Australia.
   [Rosenbaum, Simon; McKeon, Grace] Prince Wales Hosp, Black Dog Inst, Sydney, NSW, Australia.
C3 University of Western Australia; South Metropolitan Health Service;
   Central Queensland University; South Eastern Sydney Local Health
   District; University of New South Wales Sydney; University of New South
   Wales Sydney; Black Dog Institute; University of New South Wales Sydney;
   Prince of Wales Hospital (POWH)
RP Furzer, B (corresponding author), Univ Western Australia, Sch Human Sci M408, 35 Stirling Highway, Crawley 6009, Australia.
EM bonnie.furzer@uwa.edu.au
RI McMahen, Caleb/MVU-6248-2025; Wright, Kemi/ABF-8504-2020; Furzer,
   Bonnie/ABE-6541-2020; McKeon, Grace/ADI-3804-2022; Stanton,
   Rob/AAJ-5157-2020; Rosenbaum, Simon/Y-3241-2019
OI Lederman, Oscar/0000-0002-0321-5723; Furzer, Bonnie/0000-0002-0321-6988;
   McMahen, Caleb/0000-0001-6061-3886; Rosenbaum,
   Simon/0000-0002-8984-4941; McKeon, Grace/0000-0003-4722-1639
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NR 97
TC 3
Z9 3
U1 2
U2 8
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 1755-2966
EI 1878-0199
J9 MENT HEALTH PHYS ACT
JI Ment. Health Phys. Act.
PD MAR
PY 2022
VL 22
AR 100438
DI 10.1016/j.mhpa.2021.100438
EA JAN 2022
PG 13
WC Psychology, Clinical; Psychiatry
WE Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA 0Y1NS
UT WOS:000790163100006
DA 2025-06-11
ER

PT J
AU Roberts, T
   Gureje, O
   Thara, R
   Hutchinson, G
   Cohen, A
   Weiss, HA
   John, S
   Pow, JL
   Donald, C
   Olley, B
   Esponda, GM
   Murray, RM
   Morgan, C
AF Roberts, Tessa
   Gureje, Oye
   Thara, Rangaswamy
   Hutchinson, Gerard
   Cohen, Alex
   Weiss, Helen Anne
   John, Sujit
   Pow, Joni Lee
   Donald, Casswina
   Olley, Bola
   Esponda, Georgina Miguel
   Murray, Robin M.
   Morgan, Craig
TI INTREPID II: protocol for a multistudy programme of research on
   untreated psychosis in India, Nigeria and Trinidad
SO BMJ OPEN
LA English
DT Article
ID AUSTRALIAN NATIONAL-SURVEY; GLOBAL MENTAL-HEALTH; METABOLIC SYNDROME;
   CHILDHOOD TRAUMA; RISK-FACTORS; 1ST EPISODE; PSYCHOMETRIC PROPERTIES;
   1ST-EPISODE PSYCHOSIS; SYMPTOM DIMENSIONS; LIFE EXPECTANCY
AB Introduction There are few robust and directly comparable studies of the epidemiology of psychotic disorders in the Global South. INTREPID II is designed to investigate variations in untreated psychotic disorders in the Global South in (1) incidence and presentation (2) 2-year course and outcome, (3) help-seeking and impact, and (4) physical health.
   Methods INTREPID II is a programme of research incorporating incidence, case-control and cohort studies of psychoses in contiguous urban and rural areas in India, Nigeria and Trinidad. In each country, the target samples are 240 untreated cases with a psychotic disorder, 240 age-matched, sex-matched and neighbourhood-matched controls, and 240 relatives or caregivers. Participants will be followed, in the first instance, for 2 years. In each setting, we have developed and are employing comprehensive case-finding methods to ensure cohorts are representative of the target populations. Using methods developed during pilot work, extensive data are being collected at baseline and 2-year follow-up across several domains: clinical, social, help-seeking and impact, and biological.
   Ethics and dissemination Informed consent is sought, and participants are free to withdraw from the study at any time. Participants are referred to mental health services if not already in contact with these and emergency treatment arranged where necessary. All data collected are confidential, except when a participant presents a serious risk to either themselves or others. This programme has been approved by ethical review boards at all participating centres. Findings will be disseminated through international conferences, publications in international journals, and through local events for key stakeholders.
C1 [Roberts, Tessa; Esponda, Georgina Miguel; Morgan, Craig] Inst Psychiat Psychol & Neurosci, Hlth Serv Populat Res Dept, London, England.
   [Roberts, Tessa; Esponda, Georgina Miguel; Morgan, Craig] Kings Coll London, ESRC Ctr Soc & Mental Hlth, London, England.
   [Gureje, Oye] Univ Ibadan, Dept Psychiat, WHO Collaborating Ctr Res & Training Mental Hlth, Neurosci & Subst Abuse, Ibadan, Nigeria.
   [Thara, Rangaswamy] Schizophrenia Res Fdn, Chennai, Tamil Nadu, India.
   [Hutchinson, Gerard; Pow, Joni Lee; Donald, Casswina] Univ West Indies, St Augustine Fac Med Sci, Dept Psychiat, Tunapuna Piarco, Trinidad Tobago.
   [Cohen, Alex] Harvard Univ, Dept Epidemiol, TH Chan Sch Publ Hlth, Boston, MA USA.
   [Weiss, Helen Anne] London Sch Hyg & Trop Med, Epidemiol & Populat Hlth, London, England.
   [Weiss, Helen Anne] London Sch Hyg & Trop Med, London, England.
   [Olley, Bola] Univ Ibadan, Dept Psychiat, Coll Med, Ibadan, Nigeria.
   [Murray, Robin M.] Inst Psychiat Psychol & Neurosci, Dept Psychosis Studies, London, England.
C3 University of London; King's College London; UK Research & Innovation
   (UKRI); Economic & Social Research Council (ESRC); University of Ibadan;
   University West Indies Mona Jamaica; University West Indies Saint
   Augustine; Harvard University; Harvard T.H. Chan School of Public
   Health; University of London; London School of Hygiene & Tropical
   Medicine; University of London; London School of Hygiene & Tropical
   Medicine; University of Ibadan
RP Morgan, C (corresponding author), Inst Psychiat Psychol & Neurosci, Hlth Serv Populat Res Dept, London, England.; Morgan, C (corresponding author), Kings Coll London, ESRC Ctr Soc & Mental Hlth, London, England.
EM craig.morgan@kcl.ac.uk
RI Rangaswamy, Thara/JXK-9468-2024; weiss, helen/ABC-7823-2021; Gureje,
   Oye/J-1183-2014; murray, robin/F-8658-2012; Morgan, Craig/B-2100-2010
OI murray, robin/0000-0003-0829-0519; Rangaswamy,
   Thara/0000-0001-6813-066X; Morgan, Craig/0000-0002-1386-2369; Weiss,
   Helen/0000-0003-3547-7936; Miguel Esponda, Georgina/0000-0001-5616-191X;
   Gureje, Oye/0000-0003-0094-5947; John, Sujit/0000-0001-7157-3533
FU UK Medical Research Council (MRC) [MR/PO25927/1]; National Institute for
   Health Research (NIHR) Specialist Biomedical Research Centre for Mental
   Health at South London and Maudsley NHS Foundation Trust and King's
   College London; ESRC Centre for Society and Mental Health at King's
   College London [ES/S012567/1]; Wellcome Trust [WT094525]
FX This programme is funded by the UK Medical Research Council (MRC) (MRC
   Reference: MR/PO25927/1). The authors acknowledge financial support from
   the National Institute for Health Research (NIHR) Specialist Biomedical
   Research Centre for Mental Health at South London and Maudsley NHS
   Foundation Trust and King's College London, and the ESRC Centre for
   Society and Mental Health at King's College London (ESRC Reference:
   ES/S012567/1). This programme builds on research funded by the Wellcome
   Trust (WT094525).
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NR 98
TC 12
Z9 12
U1 0
U2 1
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2044-6055
J9 BMJ OPEN
JI BMJ Open
PD JUN
PY 2020
VL 10
IS 6
AR e039004
DI 10.1136/bmjopen-2020-039004
PG 10
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA VK5WI
UT WOS:000738458500142
PM 32565481
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Kim, TH
   Hwang, HJ
   Kim, SH
AF Kim, Tae Ho
   Hwang, Hee-Jin
   Kim, Sang-Hwan
TI Relationship between Serum Ferritin Levels and Sarcopenia in Korean
   Females Aged 60 Years and Older Using the Fourth Korea National Health
   and Nutrition Examination Survey (KNHANES IV-2, 3), 2008-2009
SO PLOS ONE
LA English
DT Article
ID INSULIN-RESISTANCE SYNDROME; BODY IRON STORES; METABOLIC SYNDROME;
   OXIDATIVE STRESS; SKELETAL-MUSCLE; DIABETES-MELLITUS;
   GENERAL-POPULATION; ASSOCIATION; OBESITY; ACCUMULATION
AB Context: It has been suggested that elevated serum ferritin is associated with several metabolic disorders. However, there is no reported study assessing any association between serum ferritin and sarcopenia despite the close relationship between sarcopenia and metabolic disorders.
   Objective: We investigated whether serum ferritin was associated with sarcopenia in older Koreans.
   Design and Setting: We conducted a cross-sectional study based on data acquired in the second and third years (2008-9) of the fourth Korean National Health and Nutrition Examination Survey.
   Participants: In total, 952 men (mean age 69.0 years) and 1,380 women (mean age 69.3 years) aged 60 years and older completed a body composition study using dual energy X-ray absorptiometry.
   Measurements: Serum ferritin levels were measured. Sarcopenia was defined as an appendicular skeletal mass as a percentage of body weight that was less than two standard deviations below the gender-specific mean for young adults.
   Results: Serum ferritin levels were lower in women than in men. Women with sarcopenia showed a higher level of serum ferritin than women without sarcopenia (men: without sarcopenia 115.7 ng/mL and with sarcopenia 134.4 ng/mL vs. women: without sarcopenia 70.7 ng/mL and with sarcopenia 85.4 ng/mL). The prevalence of sarcopenia increased as the tertile of serum ferritin increased. However, statistical significance was only seen in elderly women (1st tertile 6.3%, 2nd tertile 8.0%, 3rd tertile 12.0%; p = 0.008). Without adjustment, compared with those in the lowest tertile of serum ferritin level, participants in the highest tertile had an odds ratio of 2.02 (95% confidence interval = 1.26-3.23) for sarcopenia in women. After adjusting for known risk factors, the OR for sarcopenia was 1.74 (95% CI = 1.02-2.97) in women. There was no statistically significant association between sarcopenia and serum ferritin tertiles in men.
   Conclusions: Elevated serum ferritin levels were associated with an increased prevalence of sarcopenia in women but not in men from a representative sample of elderly Koreans.
C1 [Kim, Tae Ho] Kwandong Univ Coll Med, Div Endocrinol, Dept Internal Med, Kangnung, South Korea.
   [Hwang, Hee-Jin] Kwandong Univ Coll Med, Dept Family Med, Kangnung, South Korea.
   [Kim, Sang-Hwan] Myongji Hosp, Geriatr Ctr, Goyang, South Korea.
   [Kim, Sang-Hwan] Myongji Hosp, Dept Family Med, Goyang, South Korea.
C3 Catholic Kwandong University; Catholic Kwandong University; Myongji
   Hospital; Myongji Hospital
RP Hwang, HJ (corresponding author), Kwandong Univ Coll Med, Dept Family Med, Kangnung, South Korea.
EM ydsfm3624@naver.com; fanink@naver.com
OI Kim, Tae Ho/0000-0002-3720-8011
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NR 46
TC 30
Z9 32
U1 0
U2 13
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD FEB 25
PY 2014
VL 9
IS 2
AR e90105
DI 10.1371/journal.pone.0090105
PG 8
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA AC2ZX
UT WOS:000332385900117
PM 24587226
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Nankivell, J
   Platania-Phung, C
   Happell, B
   Scott, D
AF Nankivell, Janette
   Platania-Phung, Chris
   Happell, Brenda
   Scott, David
TI Access to Physical Health Care for People with Serious Mental Illness: A
   Nursing Perspective and a Human Rights Perspective-Common Ground?
SO ISSUES IN MENTAL HEALTH NURSING
LA English
DT Article
ID HIGHEST ATTAINABLE STANDARD; METABOLIC SYNDROME; RISK-FACTORS; BARRIERS;
   SCHIZOPHRENIA; PREVALENCE; MORTALITY; CONSUMERS; NURSES; DEATH
AB Relative to the general population, people with serious mental illness (SMI) experience elevated risks of physical disease and illness and live shorter lives. A human rights perspective argues that people with serious mental illness have a right to equal access to physical health care. Nurses in mental health services can contribute to improving the availability and accessibility of physical health care. This study, involving focus group interviews with nurses in a large regional and rural mental health care district of Queensland, Australia, revealed significant problems in access to physical health care for service users. The current article reports on our exploratory analysis of nurses' views and perceptions to identify (1) orientation of nurses to human rights, and (2) access of consumers with SMI to general practitioner services. It was rare for nurses to raise the topic of human rights, and when raised, it was not as a strategy for improving access to physical health care services that they felt consumers with SMI greatly needed. Two main themes were identified as causes of poor access: clinical barriers to physical care and attitudinal barriers to physical care. In light of these results, the authors explore a human rights perspective on access and how this provides an inclusive lobbying umbrella under which nurses and other groups can pursue access to physical health services that are adequate, accessible, and nondiscriminatory. The article then discusses the implications for these findings for the value of human rights as a perspective and means of increasing physical health of people with SMI.
C1 [Nankivell, Janette; Platania-Phung, Chris; Scott, David] Cent Queensland Univ, Inst Hlth & Social Sci Res, Ctr Mental Hlth Nursing Innovat, Melbourne, Vic, Australia.
   [Happell, Brenda] Cent Queensland Univ, Inst Hlth & Social Sci Res, Ctr Mental Hlth Nursing Innovat, Rockhampton, Qld 4702, Australia.
C3 Central Queensland University; Central Queensland University
RP Happell, B (corresponding author), CQUniv Australia, Sch Nursing & Midwifery, Rockhampton, Qld 4701, Australia.
EM b.happell@cqu.edu.au
RI Scott, David/AAE-5031-2021; Happell, Brenda/HSI-0570-2023
OI Scott, David/0000-0001-5226-1972; Happell, Brenda/0000-0002-7293-6583
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   United Nations, 1966, International Covenant on Economic, Social and Cultural Rights, The World Declaration on Nutrition, DOI DOI 10.18356/F95A34CA-EN-FR
NR 42
TC 15
Z9 18
U1 0
U2 14
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 0161-2840
EI 1096-4673
J9 ISSUES MENT HEALTH N
JI Issues Ment. Health Nurs.
PD JUN
PY 2013
VL 34
IS 6
BP 442
EP 450
DI 10.3109/01612840.2012.754974
PG 9
WC Nursing; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Psychiatry
GA V38TS
UT WOS:000209366300008
PM 23805929
DA 2025-06-11
ER

PT J
AU Chambers, MK
   Thomas, M
   Brimmer, MJ
   Butcher, J
   Griswold, K
AF Chambers, Meghan K.
   Thomas, Matthew
   Brimmer, Maximilian J.
   Butcher, James
   Griswold, Kim
TI Whole Person Care: Outcomes From a 5-Year Care Model Integrating Primary
   Care Into a Behavioral Health Clinic
SO FAMILIES SYSTEMS & HEALTH
LA English
DT Article
DE integrated care; reverse co-location; coordinated care; serious mental
   illness; chronic care outcomes
ID METABOLIC SYNDROME; EXCESS MORTALITY; MENTAL-DISORDERS; SCHIZOPHRENIA;
   ADULTS
AB Introduction: Integrated mental and physical health care has the potential to improve health outcomes. A behavioral health organization established a reverse integration program site using a co-located model to provide primary care services to patients receiving behavioral health services. We ask whether this model of co-located care was effective in improving a range of physical health outcomes for clients. This program was funded with a grant from the Substance Abuse and Mental Health Services Administration Primary and Behavioral Health Care Integration.Method: Patients received services in a community mental health setting that embedded primary care services. The population included adult patients with mental illness, substance use disorder (SUD), or co-occurring medical diagnoses in an urban setting. Just under half of the patients identified as non-White, and over one quarter identified as Hispanic. These characteristics demonstrate a medically complex and underserved population. This description and exploratory analysis utilized National Outcome Measures data and clinical health measures from electronic health records. We stratified data by SUD and mental illness diagnoses. We measured changes in health outcomes for this complex population of 532 patients from 2015 to 2019.Results: From enrollment to last visit, patient outcomes improved for blood pressure and cholesterol. Conversely, waist circumference and breath carbon monoxide levels significantly worsened.Discussion: This reverse integration co-location program demonstrates that positive health outcomes can be achieved through evidence-based care, adaptable clinic arrangements, and robust community connections and support. More work is needed to generate positive health outcomes in medically complex patients.
C1 [Chambers, Meghan K.; Thomas, Matthew; Brimmer, Maximilian J.; Griswold, Kim] SUNY Buffalo, Primary Care Res Inst, Jacobs Sch Med & Biomed Sci, Dept Family Med, Buffalo, NY USA.
   [Butcher, James] BestSelf Behav Hlth Inc, Buffalo, NY USA.
   [Griswold, Kim] SUNY Buffalo, Primary Care Res Inst, Jacobs Sch Med & Biomed Sci, Dept Family Med, 50 Saybrook Pl, Buffalo, NY 14209 USA.
C3 State University of New York (SUNY) System; University at Buffalo, SUNY;
   State University of New York (SUNY) System; University at Buffalo, SUNY
RP Griswold, K (corresponding author), SUNY Buffalo, Primary Care Res Inst, Jacobs Sch Med & Biomed Sci, Dept Family Med, 50 Saybrook Pl, Buffalo, NY 14209 USA.
EM griswol@buffalo.edu
RI Butcher, James/AAC-8339-2020
OI Griswold, Kim/0000-0002-0321-8879; Chambers, Meghan/0000-0001-7932-4427
FU Substance Abuse and Mental Health Services Administration [SM062404-01]
FX This work is supported by the Substance Abuse and Mental Health Services
   Administration (Grant Award Number SM062404-01). The funder did not have
   a role in the preparation of this manuscript.
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NR 42
TC 1
Z9 1
U1 1
U2 2
PU EDUCATIONAL PUBLISHING FOUNDATION-AMERICAN PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST, NE, WASHINGTON, DC 20002-4242 USA
SN 1091-7527
EI 1939-0602
J9 FAM SYST HEALTH
JI Fam. Syst. Health
PD SEP
PY 2023
VL 41
IS 3
BP 332
EP 341
DI 10.1037/fsh0000794
EA MAR 2023
PG 10
WC Health Care Sciences & Services; Family Studies; Public, Environmental &
   Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services; Family Studies; Public, Environmental &
   Occupational Health
GA T9IG3
UT WOS:000952301500001
PM 36931824
OA hybrid
DA 2025-06-11
ER

PT J
AU Srisurapanont, M
   Suttajit, S
   Maneeton, N
   Maneeton, B
AF Srisurapanont, Manit
   Suttajit, Sirijit
   Maneeton, Narong
   Maneeton, Benchalak
TI Efficacy and safety of aripiprazole augmentation of clozapine in
   schizophrenia: A systematic review and meta-analysis of
   randomized-controlled trials
SO JOURNAL OF PSYCHIATRIC RESEARCH
LA English
DT Review
DE Aripiprazole; Drug augmentation; Clozapine; Schizophrenia; Metabolic
   syndrome; Adverse effects
ID TREATMENT-RESISTANT SCHIZOPHRENIA; WEIGHT-GAIN; METABOLIC ABNORMALITIES;
   PHYSICAL ILLNESS; TREATED PATIENTS; DOUBLE-BLIND; MANAGEMENT;
   HALOPERIDOL; COMBINATION; OUTPATIENTS
AB Limited options are available for clozapine-resistant schizophrenia and intolerable side effects of clozapine. We conducted a systematic review of randomized-controlled trials (RU's) to determine the efficacy and safety of aripiprazole augmentation of clozapine for schizophrenia. Electronic databases searched included PubMed, Scopus, Cochrane Central Register of Controlled Trials, Cumulative Index to Nursing and Allied Health Literature (CINAHL), and Web of Science. This review synthesized the data of four short-term (8-24 weeks), placebo-controlled trials (N = 347). The overall relative risk (RR, 95% confidence interval) of discontinuation rates was not significantly different between groups (RR = 1.41, 95% CI = 0.78 to 2.56). The pooled standardized mean differences (SMDs, 95% CIs) (Z-test; number of study; I-2-index) suggested trends of aripiprazole augmentation benefits on overall psychotic [-0.40 (-0.87 to 0.07) (n = 3; Z = 1.68, p = 0.09; I-2 = 68%)], positive [-1.05 (-2.39 to 029) (n = 3; Z = 1.54, p = 0.12; I-2 = 94%)], and negative [-0.36 (-0.77 to 0.05) (n = 3; Z = 1.74, p = 0.08; I-2 = 54%)] symptoms. Despite of no benefit on three cardiometabolic indices (i.e., fasting plasma glucose, triglyceride, and high-density lipoprotein), aripiprazole augmentation was superior for weight change with a mean difference (95% CI) of -1.36 kg (-2.35 to -0.36) (n = 3; Z = 2.67, p = 0.008; I-2 = 39%) and LDL-cholesterol with a mean difference of -11.06 mg/dL (-18.25 to -3.87) (n = 3; Z = 3.02, p = 0.003; I-2 = 31%). Aripiprazole augmentation was not correlated with headache and insomnia but significantly associated with agitation/akathesia (RR = 7.59, 95% CI = 1.43 to 40.18) (n = 3; Z = 238, p = 0.02; I-2 = 0%) and anxiety (RR = 2.70, 95% CI = 1.02 to 7.15) (n = 1; Z = 2.00, p = 0.05). The limited short-term data suggested that aripiprazole augmentation of clozapine can minimize the cardiometabolic risk, causes agitation/akathesia, and may be effective in attenuating psychotic symptoms. (C) 2015 Elsevier Ltd. All rights reserved.
C1 [Srisurapanont, Manit; Suttajit, Sirijit; Maneeton, Narong; Maneeton, Benchalak] Chiang Mai Univ, Dept Psychiat, Fac Med, Chiang Mai 50200, Thailand.
C3 Chiang Mai University
RP Srisurapanont, M (corresponding author), Chiang Mai Univ, Dept Psychiat, Fac Med, 110 Intavaroros Rd, Chiang Mai 50200, Thailand.
EM manit.s@cmu.ac.th
RI Maneeton, Narong/AGE-3159-2022; Srisurapanont, Manit/R-9997-2017
OI Suttajit, Sirijit/0000-0002-6408-769X; Srisurapanont,
   Manit/0000-0001-6203-1206; Maneeton, Benchalak/0000-0001-6125-6489;
   Maneeton, Narong/0000-0001-6882-6720
FU AstraZeneca; Janssen-Cilag; JohnsonJohnson; Lundbeck; Thai-Otsuka;
   Sanofi-Aventis; Servier; Astra-Zeneca
FX MS received honoraria, consultancy fees, research grants, and/or travel
   reimbursement from AstraZeneca, Janssen-Cilag, Johnson&Johnson,
   Lundbeck, Thai-Otsuka, Sanofi-Aventis, and Servier. SS received
   honoraria and/or consultancy fees from Astra-Zeneca, Janssen-Cilag,
   Lundbeck, and Thai-Otsuka. NM received travel reimbursement from
   Thai-Otsuka and Lundbeck. BM received honoraria and/or travel
   reimbursement from GlaxoSmithKline and Pfizer.
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NR 43
TC 44
Z9 44
U1 0
U2 15
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-3956
EI 1879-1379
J9 J PSYCHIATR RES
JI J. Psychiatr. Res.
PD MAR
PY 2015
VL 62
BP 38
EP 47
DI 10.1016/j.jpsychires.2015.01.004
PG 10
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA CE4GS
UT WOS:000351789700005
PM 25619176
DA 2025-06-11
ER

PT J
AU Liu, CS
   Carvalho, AF
   McIntyre, RS
AF Liu, Celina S.
   Carvalho, Andre F.
   McIntyre, Roger S.
TI Towards a "Metabolic" Subtype of Major Depressive Disorder: Shared
   Pathophysiological Mechanisms May Contribute to Cognitive Dysfunction
SO CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
LA English
DT Article
DE Body mass index; cognition; co-morbidity; major depressive disorder;
   metabolic disorders; obesity
ID GLUCAGON-LIKE PEPTIDE-1; HIPPOCAMPAL SYNAPTIC PLASTICITY;
   CENTRAL-NERVOUS-SYSTEM; NECROSIS-FACTOR-ALPHA; QUALITY-OF-LIFE;
   NEUROTROPHIC FACTOR; INSULIN-RESISTANCE; OXIDATIVE STRESS; RISK-FACTORS;
   INTRANASAL INSULIN
AB Major depressive disorder (MDD) is frequently associated with significant cognitive dysfunction. Furthermore, MDD is often co-morbid with obesity and metabolic disorders. The aim of this review is to evaluate the pathophysiological role obesity and co-morbid metabolic disorders may play in cognitive dysfunction associated with MDD. We conducted a PubMed search from December 1st 2013 to May 31st 2014 of all English language publications including the following keywords: cognition, working memory, attention, executive functioning, inflammation, insulin, brain-derived neurotrophic factor, neurotrophins, incretins, glucagon-like peptide-1, adipokines, diabetes, oxidative stress and glucocorticoids, cross-referenced with MDD and obesity, metabolic disorders, or metabolic syndrome. Clinical and epidemiological studies indicate that metabolic disturbances may contribute to cognitive dysfunction in MDD. There are several overlapping pathophysiological mechanisms linking obesity and metabolic abnormalities to MDD including disturbances in the hypothalamic pituitary adrenal axis, abnormalities in brain-derived neurotrophic factor signaling, adipose-derived hormones, insulin signalling, inflammatory cytokines, as well as oxidative and nitrosative stress pathways. Based on current research results, this article presents several putative mechanisms underlying the effects of obesity and metabolic abnormalities on cognitive dysfunction in MDD. Metabolic MDD may represent a depression subtype with unique patho-etiological mechanisms. The diverse shared pathophysiological mechanisms elucidated in this review may provide novel targets for the prevention and/or treatment of cognitive deficits in MDD.
C1 [Liu, Celina S.] Univ Toronto, Dept Human Biol, Toronto, ON, Canada.
   [Liu, Celina S.; McIntyre, Roger S.] Toronto Western Hosp, Mood Disorders Psychopharmacol Unit, Toronto, ON M5T 2S8, Canada.
   [Carvalho, Andre F.] Univ Fed Ceara, Translat Psychiat Res Grp, Fortaleza, Ceara, Brazil.
   [Carvalho, Andre F.] Univ Fed Ceara, Dept Clin Med, Fortaleza, Ceara, Brazil.
   [McIntyre, Roger S.] Univ Toronto, Dept Psychiat, Toronto, ON, Canada.
   [McIntyre, Roger S.] Univ Toronto, Dept Pharmacol, Toronto, ON, Canada.
C3 University of Toronto; University of Toronto; University Health Network
   Toronto; Universidade Federal do Ceara; Universidade Federal do Ceara;
   University of Toronto; University of Toronto
RP Liu, CS (corresponding author), Univ Toronto, Dept Human Biol, Toronto, ON, Canada.
EM celina.liu@mail.utoronto.ca
RI McIntyre, Roger/AAU-1000-2020; Carvalho, Andre/AEZ-4001-2022
FU Conselho de Desenvolvimento Cientifico e Tecnologico (Level II, Brazil)
FX AFC is funded by a research scholarship award from Conselho de
   Desenvolvimento Cientifico e Tecnologico (Level II, Brazil). CSL would
   like to acknowledge J. Lieu from the University of Toronto.
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NR 233
TC 52
Z9 55
U1 0
U2 20
PU BENTHAM SCIENCE PUBL
PI BUSUM
PA PO BOX 294, BUSUM, 1400 AG, NETHERLANDS
SN 1871-5273
EI 1996-3181
J9 CNS NEUROL DISORD-DR
JI CNS Neurol. Disord.-Drug Targets
PY 2014
VL 13
IS 10
BP 1693
EP 1707
PG 15
WC Neurosciences; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pharmacology & Pharmacy
GA CA0GG
UT WOS:000348594400008
PM 25470395
DA 2025-06-11
ER

PT J
AU Da Ronch, C
   Canuto, A
   Volkert, J
   Massarenti, S
   Weber, K
   Dehoust, MC
   Nanni, MG
   Andreas, S
   Sehner, S
   Schulz, H
   Härter, M
   Grassi, L
AF Da Ronch, C.
   Canuto, A.
   Volkert, J.
   Massarenti, S.
   Weber, K.
   Dehoust, M. C.
   Nanni, M. G.
   Andreas, S.
   Sehner, S.
   Schulz, H.
   Haerter, M.
   Grassi, L.
TI Association of television viewing with mental health and mild cognitive
   impairment in the elderly in three European countries, data from the
   MentDis_ICF65+project
SO MENTAL HEALTH AND PHYSICAL ACTIVITY
LA English
DT Article
DE Elderly; Sedentary behaviour; Television; Mental health; Cognition;
   Europe
ID PHYSICAL-ACTIVITY QUESTIONNAIRE; TYPE-2 DIABETES-MELLITUS; METABOLIC
   SYNDROME; CARDIOVASCULAR-DISEASE; SEDENTARY BEHAVIOR; INACTIVITY
   PHYSIOLOGY; STATE-EXAMINATION; LIFE-STYLE; RISK; TIME
AB Background: Time spent watching TV by Europeans has been calculated to be 22.1 h per week on average and it has shown to be correlated with a series of physical and mental problems in adults. Very little research is available in population over 65. This study aimed at evaluating the association between TV viewing and mental disorders and cognitive performance, taking into account the general physical activity level and sodo-demographic characteristics in Europe.
   Methods: Within the MentDis_ICF65+ study, a subsample of 1383 subjects aged 65-84 years were assessed by the Composite International Diagnostic Interview (CIDI65+) and the International Physical Activity Questionnaire (IPAQ) for physical activity evaluation. Time spent in watching TV was assessed through a self report instrument.
   Results: Forty-three per cent of the total sample watched TV for 5-7 days a week for 2 or more hours every day. Females, people who lived alone, older subjects and those with lower education significantly watched TV for a longer time. Stepwise multiple regression showed statistically significant inverse correlation between Mini-Mental State Examination scores and TV viewing time (p < 0.001). Apart from a negative association-with Major Depressive Disorder, no particular associations were found between TV viewing and psychopathological diagnoses.
   Conclusions: Given the relationship of time spending watching TV with cognitive impairment, awareness should be raised about the possible negative effects of TV viewing on the elderly and programs to reduce TV viewing time should be set up. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Da Ronch, C.; Massarenti, S.; Nanni, M. G.; Grassi, L.] Dept Biomed & Specialty Surg Sci, Sect Psychiat, I-44121 Ferrara, Italy.
   [Canuto, A.; Weber, K.] Univ Hosp Geneva HUG, Dept Psychiat & Mental Hlth, Div Liaison Psychiat & Crisis Intervent, CH-1211 Geneva 14, Switzerland.
   [Volkert, J.; Dehoust, M. C.; Andreas, S.; Schulz, H.; Haerter, M.] Univ Med Ctr Hamburg Eppendorf, Dept Med Psychol, D-20246 Hamburg, Germany.
   [Andreas, S.] Alpen Adria Univ Klagenfurt, Inst Psychol, A-9020 Klagenfurt, Austria.
   [Sehner, S.] Univ Med Ctr Hamburg Eppendorf, Dept Biometry & Epidemiol, D-20246 Hamburg, Germany.
C3 University of Hamburg; University Medical Center Hamburg-Eppendorf;
   University of Klagenfurt; University of Hamburg; University Medical
   Center Hamburg-Eppendorf
RP Da Ronch, C (corresponding author), Dept Biomed & Specialty Surg Sci, Sect Psychiat, Via Fossato di Mortara 64-B, I-44121 Ferrara, Italy.
EM chiara.daronch@unife.it; alessandra.canuto@hcuge.ch; jvolkert@uke.de;
   sara.massarenti@unife.it; kerstin.weber@hcuge.ch; m.dehoust@uke.de;
   mariagiulia.nanni@unife.it; sandreas@uke.de; s.sehner@uke.de;
   schulz@uke.de; m.haerter@uke.de; luigi.grassi@unife.it
RI Volkert, Jana/ABE-3460-2020; Costanza, Alessandra/ABD-8231-2020
OI Harter, Martin/0000-0001-7443-9890; Nanni, Maria
   Giulia/0000-0002-1085-4339; GRASSI, Luigi/0000-0002-1050-4494; Volkert,
   Jana/0000-0003-1555-2599; Andreas, Sylke/0000-0002-1060-1411
FU European Commission within the 7th Framework Research Program of the EU
   [223105]
FX This study is funded by a grant from the European Commission (Grant No:
   223105) within the 7th Framework Research Program of the EU.
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NR 60
TC 22
Z9 25
U1 0
U2 35
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1755-2966
J9 MENT HEALTH PHYS ACT
JI Ment. Health Phys. Act.
PD MAR
PY 2015
VL 8
BP 8
EP 14
DI 10.1016/j.mhpa.2014.11.002
PG 7
WC Psychology, Clinical; Psychiatry
WE Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA CL1YK
UT WOS:000356740600002
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Chen, YY
   Zhang, F
   Yan, YA
   Wang, SQ
   Zhang, L
   Yan, FP
AF Chen, Yuanyuan
   Zhang, Fu
   Yan, Yanan
   Wang, Shiquan
   Zhang, Le
   Yan, Fengping
TI Sudden Cardiac Death in Schizophrenia During Hospitalization: An
   Autopsy-Based Study
SO FRONTIERS IN PSYCHIATRY
LA English
DT Article
DE schizophrenia; hospitalization; sudden cardiac death; antipsychotic;
   autopsy
ID METABOLIC SYNDROME; CARDIOVASCULAR MORTALITY; ANTIPSYCHOTIC-DRUGS; LIFE
   EXPECTANCY; RISK
AB Schizophrenia is a severe mental disorder that is often comorbid with heart dysfunction and even sudden cardiac death (SCD). Clinical studies of SCD in schizophrenia have been largely reported, while there are limited autopsy studies that directly showed whole-scale information of such events. In this study, we present nine autopsy-based SCD cases in schizophrenia patients who died suddenly during hospitalization. Their medical records before and during hospitalization, and postmortem autopsy findings were summarized. These decedents had an average duration of schizophrenia for 6.83 +/- 3.75 years with a male/female ratio of 4:5. They were all on intermittent antipsychotics medication before hospitalization and died within 15 days after hospitalization. Seven of the nine cases (77.8%) died of organic heart diseases such as severe coronary artery atherosclerosis (n = 4), myocarditis (n = 1), cardiomyopathy (n = 1), and pulmonary thromboembolism (n = 1). Two cases remained unexplained after systemic autopsy and toxicological examinations. Postmortem autopsy identified hepatic steatosis (n = 6) and respiratory inflammation (n = 3) as the most common associate extra-cardiac lesions. Our data provided autopsy-based data of SCD cases in schizophrenia and highlighted an intensive care of such patients during hospitalization.
C1 [Chen, Yuanyuan; Yan, Yanan; Wang, Shiquan; Yan, Fengping] Gannan Med Univ, Sch Basic Med Sci, Dept Forens Med, Ganzhou, Peoples R China.
   [Chen, Yuanyuan; Yan, Yanan; Wang, Shiquan; Yan, Fengping] Gannan Med Univ, Key Lab Prevent & Treatment Cardiovasc & Cerebrova, Minist Educ, Ganzhou, Peoples R China.
   [Zhang, Fu] Publ Secur Bur, Criminal Technol Ctr Guangdong Prov, Guangzhou, Peoples R China.
   [Zhang, Le] Gannan Med Univ, Forens Ctr, Ganzhou, Peoples R China.
C3 Gannan Medical University; Gannan Medical University; Ministry of
   Education - China; Gannan Medical University
RP Yan, FP (corresponding author), Gannan Med Univ, Sch Basic Med Sci, Dept Forens Med, Ganzhou, Peoples R China.; Yan, FP (corresponding author), Gannan Med Univ, Key Lab Prevent & Treatment Cardiovasc & Cerebrova, Minist Educ, Ganzhou, Peoples R China.
EM tomjiangxi@163.com
RI yan, feng/JAX-8275-2023; Wang, Sui-Dong/E-6063-2013
FU Open Project of Key Laboratory of Forensic Pathology, Ministry of Public
   Security [GAFYBL201903]; Science and Technology Project of Jiangxi
   Provincial Department of Education [GJJ160979]; Research Project of
   Gannan Medical University [XN201924]; Open Project of Key Laboratory of
   Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases
   of Ministry of Education [XN201810]
FX This work was financially funded by the Open Project of Key Laboratory
   of Forensic Pathology, Ministry of Public Security (No. GAFYBL201903),
   the Science and Technology Project of Jiangxi Provincial Department of
   Education (No. GJJ160979), the Research Project of Gannan Medical
   University (No. XN201924), and Open Project of Key Laboratory of
   Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases
   of Ministry of Education (No. XN201810).
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NR 33
TC 4
Z9 4
U1 1
U2 7
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-0640
J9 FRONT PSYCHIATRY
JI Front. Psychiatry
PD JUL 1
PY 2022
VL 13
AR 933025
DI 10.3389/fpsyt.2022.933025
PG 7
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 3B5XZ
UT WOS:000828014700001
PM 35845458
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Lounici, A
   Iacob, A
   Hongler, K
   Mölling, MA
   Drechsler, M
   Hersberger, L
   Sethi, S
   Lang, UE
   Liwinski, T
AF Lounici, Astrid
   Iacob, Ana
   Hongler, Katarzyna
   Moelling, Melina A.
   Drechsler, Maria
   Hersberger, Luca
   Sethi, Shebani
   Lang, Undine E.
   Liwinski, Timur
TI Ketogenic Diet as a Nutritional Metabolic Intervention for
   Obsessive-Compulsive Disorder: A Narrative Review
SO NUTRIENTS
LA English
DT Review
DE ketogenic diet; obsessive-compulsive disorder; metabolic syndrome;
   metabolic psychiatry; nutritional therapy
ID LOW-FAT DIET; GENERALIZED ANXIETY DISORDER; LOW-CARBOHYDRATE; OXIDATIVE
   STRESS; MITOCHONDRIAL DYSFUNCTION; CARDIOVASCULAR-DISEASES; PREFRONTAL
   CORTEX; BODY METABOLISM; MOOD DISORDERS; ADULT PATIENTS
AB The substantial evidence supporting the ketogenic diet (KD) in epilepsy management has spurred research into its effects on other neurological and psychiatric conditions. Despite differences in characteristics, symptoms, and underlying mechanisms, these conditions share common pathways that the KD may influence. The KD reverses metabolic dysfunction. Moreover, it has been shown to support neuroprotection through mechanisms such as neuronal energy support, inflammation reduction, amelioration of oxidative stress, and reversing mitochondrial dysfunction. The adequate intake of dietary nutrients is essential for maintaining normal brain functions, and strong evidence supports the role of nutrition in the treatment and prevention of many psychiatric and neurological disorders. Obsessive-compulsive disorder (OCD) is a neuropsychiatric condition marked by persistent, distressing thoughts or impulses (obsessions) and repetitive behaviors performed in response to these obsessions (compulsions). Recent studies have increasingly examined the role of nutrition and metabolic disorders in OCD. This narrative review examines current evidence on the potential role of the KD in the treatment of OCD. We explore research on the KD's effects on psychiatric disorders to assess its potential relevance for OCD treatment. Additionally, we identify key gaps in the preclinical and clinical research that warrant further study in applying the KD as a metabolic therapy for OCD.
C1 [Lounici, Astrid; Hongler, Katarzyna; Lang, Undine E.; Liwinski, Timur] Univ Basel, Univ Psychiat Clin Basel, Clin Adults, CH-4031 Basel, Switzerland.
   [Iacob, Ana] Hop Valais, Unite Psychiat Liaison, Pole Psychiat & Psychotherapie PPP, CH-1950 Sion, Switzerland.
   [Moelling, Melina A.] MEDIAN Zentrum Verhaltensmed, D-31812 Bad Pyrmont, Germany.
   [Drechsler, Maria; Hersberger, Luca] Klin SGM Langenthal, Stiftung Ganzheitl Med SGM, CH-4900 Langenthal, Switzerland.
   [Sethi, Shebani] Stanford Univ, Dept Psychiat & Behav Sci, Metab Psychiat, Sch Med, Palo Alto, CA 94305 USA.
C3 University of Basel; Stanford University
RP Liwinski, T (corresponding author), Univ Basel, Univ Psychiat Clin Basel, Clin Adults, CH-4031 Basel, Switzerland.
EM astrid.lounici@upk.ch; ana.iacob@hopitalvs.ch; katarzyna.hongler@upk.ch;
   melina.anastasia.moelling@gmail.com; maria.drechsler@klinik-sgm.ch;
   luca.hersberger@klinik-sgm.ch; shebanis@stanford.edu;
   undine.lang@upk.ch; timur.liwinski@upk.ch
RI Lang, Undine/K-5553-2015
OI Iacob, Ana/0009-0001-1079-4460; Sethi, Shebani/0000-0001-6938-2471
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NR 237
TC 0
Z9 0
U1 1
U2 1
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JAN
PY 2025
VL 17
IS 1
AR 31
DI 10.3390/nu17010031
PG 25
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA R8G6F
UT WOS:001393767700001
PM 39796465
OA gold
DA 2025-06-11
ER

PT J
AU Corazza, DI
   Sebastiao, É
   Pedroso, RV
   Andreatto, CAA
   Coelho, FGD
   Gobbi, S
   Teodorov, E
   Santos-Galduróz, RF
AF Corazza, Danilla Icassatti
   Sebastiao, Emerson
   Pedroso, Renata Valle
   Almeida Andreatto, Carla Andreza
   de Melo Coelho, Flavia Gomes
   Gobbi, Sebastiao
   Teodorov, Elizabeth
   Santos-Galduroz, Ruth Ferreira
TI Influence of chronic exercise on serum cortisol levels in older adults
SO EUROPEAN REVIEW OF AGING AND PHYSICAL ACTIVITY
LA English
DT Review
DE Cortisol; Exercise; Aging; Older people; Stress
ID HORMONAL RESPONSE PATTERNS; CHRONIC STRESS; RESISTANCE EXERCISE;
   METABOLIC SYNDROME; MUSCLE STRENGTH; MEN; WOMEN; ADAPTATIONS;
   NEUROENDOCRINE; DEPRESSION
AB The circulating level of cortisol is regulated by the hypothalamic-pituitary-adrenal axis through a neuroendocrine feedback circuit. This circuit can be activated by physiological stimuli such as stress, diseases, and exercise. High levels of serum cortisol hormone normally occur as a byproduct of aging, and can cause several types of damage to the organism and exacerbate immunosenescence. There is a great deal of variability in the cortisol response with regard to type, intensity, volume, and frequency of exercise. However, these relationships have been extensively studied with respect to the acute effects of exercise. Despite the well-known effects of acute exercise on cortisol response, it is unclear how it is affected by chronic exercise and the aging process. Therefore, the aim of this study was to conduct a review of studies that attempt to analyze the influence of chronic exercise on serum cortisol hormone in older people. In order to accomplish this goal, a review from 1970 to June 2012 period was performed using the following databases: Biological Abstracts, PsycINFO, PubMed/Medline, and the Web of Science. Eight articles met the criteria used in this study. Based on the included articles, chronic exercise may influence the serum levels of cortisol levels in older people. Despite this evidence, these results may not be generalized to the entire population of older people, given the few number of studies and especially because the studies showed diversity in variables and methodologies.
C1 [Corazza, Danilla Icassatti; Pedroso, Renata Valle; Almeida Andreatto, Carla Andreza; de Melo Coelho, Flavia Gomes; Gobbi, Sebastiao] UNESP Univ Estadual Paulista, Inst Biosci, Dept Phys Educ, Phys Act & Aging Lab LAFE, BR-13506900 Sao Paulo, Brazil.
   [Sebastiao, Emerson] Univ Illinois, Dept Kinesiol & Community Hlth, Urbana, IL 61801 USA.
   [Sebastiao, Emerson] Univ Illinois, Aging & Divers Lab ADL, Urbana, IL 61801 USA.
   [Teodorov, Elizabeth; Santos-Galduroz, Ruth Ferreira] Univ Fed ABC, Ctr Math Comp & Cognit, BR-09715000 Sao Paulo, Brazil.
C3 Universidade Estadual Paulista; University of Illinois System;
   University of Illinois Urbana-Champaign; University of Illinois System;
   University of Illinois Urbana-Champaign; Universidade Federal do ABC
   (UFABC)
RP Corazza, DI (corresponding author), UNESP Univ Estadual Paulista, Inst Biosci, Dept Phys Educ, Phys Act & Aging Lab LAFE, Ave 24 A,1515 Bela Vista, BR-13506900 Sao Paulo, Brazil.
EM danillacorazza@gmail.com; esebast2@illinois.edu; re.pedroso@hotmail.com;
   carla_andreatto@yahoo.com.br; flaviaeduca@yahoo.com.br;
   sgobbi@rc.unesp.br; elizabeth.teodorov@ufabc.edu.br;
   ruthfsantos@gmail.com
RI Santos-Galduróz, Ruth/B-8556-2012; Sebastiao, Emerson/ABF-7353-2020; de
   Almeida Andreatto, Carla/AAT-7075-2020; Pedroso, Renata/M-3535-2017
OI Pedroso, Renata/0000-0002-3583-2566; de Almeida Andreatto, Carla
   Andreza/0000-0002-0413-4108
FU FAPESP (Fundacao de Amparo a Pesquisa do Estado de Sao Paulo)
   [2011/07374-8]; CAPES (Coordenacao de Aperfeicoamento de Pessoal de
   Nivel Superior); Swedish Research Council [2011-07374] Funding Source:
   Swedish Research Council; Fundacao de Amparo a Pesquisa do Estado de Sao
   Paulo (FAPESP) [11/07374-8] Funding Source: FAPESP
FX The authors would like to acknowledge LAFE (Laboratorio de Atividade
   Fisica e Envelhecimento) and Prof. Rodrigo Dalia (Laboratorio de
   Fisiologia Experimental) from Departamento de Educacao
   Fisica-Universidade Estadual Paulista (UNESP-Rio Claro/SP); Prof. Peter
   Fitschen (Exercise & Cardiovascular Research Laboratory) from the
   Department of Kinesiology and Community Health, University of Illinois
   at Urbana-Champaign; and financial support from FAPESP (Fundacao de
   Amparo a Pesquisa do Estado de Sao Paulo, Process n. 2011/07374-8) and
   CAPES (Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior).
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NR 53
TC 28
Z9 31
U1 1
U2 33
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1813-7253
EI 1861-6909
J9 EUR REV AGING PHYS A
JI Eur. Rev. Aging Phys. Act.
PD APR
PY 2014
VL 11
IS 1
BP 25
EP 34
DI 10.1007/s11556-013-0126-8
PG 10
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA AF4KK
UT WOS:000334680600003
OA hybrid
DA 2025-06-11
ER

PT J
AU Liu, CN
   Zhao, MD
   Zhao, YH
   Hu, YJ
AF Liu, Chenning
   Zhao, Meiduo
   Zhao, Yonghua
   Hu, Yuanjia
TI Association between serum total testosterone levels and metabolic
   syndrome among adult women in the United States, NHANES 2011-2016
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Article
DE serum total testosterone levels; metabolic syndrome; women; adults;
   NHANES (National Health and Nutrition Examination Survey)
ID POLYCYSTIC-OVARY-SYNDROME; HORMONE-BINDING GLOBULIN; INSULIN-RESISTANCE;
   RISK; COMPONENTS; OBESITY; TRENDS; MEN; AGE
AB ObjectiveTo investigate the association between serum total testosterone (TT) levels and metabolic syndrome (MetS) or its components among adult women. Methods2,678 women from NHANES 2011-2016 were included in this cross-sectional study. MetS was determined according to the National Cholesterol Education Program Adult Treatment Panel III guidelines. The association between serum TT levels and MetS was evaluated by two logistics regression models and the adjusted restricted cubic spline (RCS). Stratified analysis and sensitive analysis were also conducted. ResultsContinuous TT levels were negatively associated with the occurrence of MetS, and the ORs associated with per SD increase in ln TT were 0.70 (95%CI: 0.58-0.85) in 2011-2014 and 0.56 (95%CI: 0.39-0.79) in 2015-2016 in Model A. High TT group were less likely to have MetS (OR=0.60, 95%CI: 0.45-0.80 in 2011-2014 and OR=0.50, 95%CI: 0.32-0.78 in 2015-2016) when compared to the low TT group. When TT levels were divided into quartiles, TT levels were negatively correlated with the incidence of MetS (p for trend < 0.001). Similar trend was observed in Model B. Multivariate-adjusted logistic regression with RCS exhibited that TT had a L-shaped dose-response association with MetS or its components. Interaction analyses revealed that women who were less than 50 years old (OR=0.37, 95%CI: 0.22, 0.63), with depression (OR=0.50, 95%CI: 0.29, 0.87) or being smokers (OR=0.37, 95%CI: 0.23, 0.54) showed lower ORs than those who were over 50 years old (OR=0.66, 95%CI: 0.40, 1.09), without depression (OR=0.59, 95%CI: 0.41, 0.85) or non-smokers (OR=0.59, 95%CI: 0.39, 0.89) when measure the association between ln TT and the occurrence of MetS. ConclusionsOur study indicated that TT levels are negatively correlated with the occurrence of MetS, with interaction effects of age, smoke behaviors, and depressive status.
C1 [Liu, Chenning; Zhao, Yonghua; Hu, Yuanjia] Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Macau, Macao, Peoples R China.
   [Liu, Chenning; Hu, Yuanjia] Univ Macau, Fac Hlth Sci, Dept Publ Hlth & Med Adm, Macau, Macao, Peoples R China.
   [Zhao, Meiduo] Chinese Acad Med Sci, Peking Union Med Coll, Inst Basic Med Sci, Dept Epidemiol & Biostat,Sch Basic Med, Beijing, Peoples R China.
C3 University of Macau; University of Macau; Chinese Academy of Medical
   Sciences - Peking Union Medical College; Peking Union Medical College
RP Hu, YJ (corresponding author), Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Macau, Macao, Peoples R China.; Hu, YJ (corresponding author), Univ Macau, Fac Hlth Sci, Dept Publ Hlth & Med Adm, Macau, Macao, Peoples R China.
EM yuanjiahu@um.edu.mo
RI Zhao, Yonghua/AAC-4728-2019; Hu, Yuanjia/AAW-7721-2021
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NR 40
TC 14
Z9 14
U1 2
U2 9
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD FEB 9
PY 2023
VL 14
AR 1053665
DI 10.3389/fendo.2023.1053665
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 9D2XA
UT WOS:000935964300001
PM 36843599
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Heinzer, R
   Vat, S
   Marques-Vidal, P
   Marti-Soler, H
   Andries, D
   Tobback, N
   Mooser, V
   Preisig, M
   Malhotra, A
   Waeber, G
   Vollenweider, P
   Tafti, M
   Haba-Rubio, J
AF Heinzer, R.
   Vat, S.
   Marques-Vidal, P.
   Marti-Soler, H.
   Andries, D.
   Tobback, N.
   Mooser, V.
   Preisig, M.
   Malhotra, A.
   Waeber, G.
   Vollenweider, P.
   Tafti, M.
   Haba-Rubio, J.
TI Prevalence of sleep-disordered breathing in the general population: the
   HypnoLaus study
SO LANCET RESPIRATORY MEDICINE
LA English
DT Article
ID CARDIOVASCULAR RISK-FACTORS; POSITIVE AIRWAY PRESSURE; APNEA-HYPOPNEA;
   HEART HEALTH; METABOLIC SYNDROME; ASSOCIATION; ADULTS; MEN;
   HYPERTENSION; COMMUNITY
AB Background Sleep-disordered breathing is associated with major morbidity and mortality. However, its prevalence has mainly been selectively studied in populations at risk for sleep-disordered breathing or cardiovascular diseases. Taking into account improvements in recording techniques and new criteria used to define respiratory events, we aimed to assess the prevalence of sleep-disordered breathing and associated clinical features in a large population-based sample.
   Methods Between Sept 1, 2009, and June 30, 2013, we did a population-based study (HypnoLaus) in Lausanne, Switzerland. We invited a cohort of 3043 consecutive participants of the CoLaus/PsyCoLaus study to take part. Polysomnography data from 2121 people were included in the final analysis. 1024 (48%) participants were men, with a median age of 57 years (IQR 49-68, range 40-85) and mean body-mass index (BMI) of 25.6 kg/m(2) (SD 4.1). Participants underwent complete polysomnographic recordings at home and had extensive phenotyping for diabetes, hypertension, metabolic syndrome, and depression. The primary outcome was prevalence of sleep-disordered breathing, assessed by the apnoea-hypopnoea index.
   Findings The median apnoea-hypopnoea index was 6-9 events per h (IQR 2.7-14.1) in women and 14.9 per h (7.2-27.1) in men. The prevalence of moderate-to-severe sleep-disordered breathing (>= 15 events per h) was 23.4% (95% CI 20.9-26.0) in women and 49.7% (46.6-52.8) in men. After multivariable adjustment, the upper quartile for the apnoea-hypopnoea index (>20.6 events per h) was associated independently with the presence of hypertension (odds ratio 1.60, 95% CI 1.14-2.26; p=0.0292 for trend across severity quartiles), diabetes (2.00, 1.05-3.99; p=0.0467), metabolic syndrome (2.80, 1.86-4.29; p<0.0001), and depression (1.92, 1.01-3.64; p=0.0292).
   Interpretation The high prevalence of sleep-disordered breathing recorded in our population-based sample might be attributable to the increased sensitivity of current recording techniques and scoring criteria. These results suggest that sleep-disordered breathing is highly prevalent, with important public health outcomes, and that the definition of the disorder should be revised.
C1 [Heinzer, R.; Vat, S.; Andries, D.; Tobback, N.; Tafti, M.; Haba-Rubio, J.] Univ Lausanne Hosp, Ctr Invest & Res Sleep, Lausanne, Switzerland.
   [Heinzer, R.] Univ Lausanne Hosp, Dept Pulm, Lausanne, Switzerland.
   [Marques-Vidal, P.; Waeber, G.; Vollenweider, P.] Univ Lausanne Hosp, Dept Internal Med, Lausanne, Switzerland.
   [Mooser, V.] Univ Lausanne Hosp, Dept Lab, Lausanne, Switzerland.
   [Preisig, M.] Univ Lausanne Hosp, Dept Psychiat, Lausanne, Switzerland.
   [Vat, S.] Univ Hosp Montreal, Dept Pulm Med, Montreal, PQ, Canada.
   [Marti-Soler, H.] Univ Lausanne, Inst Social & Prevent Med, CH-1011 Lausanne, Switzerland.
   [Tafti, M.] Univ Lausanne, Ctr Integrat Genom, CH-1011 Lausanne, Switzerland.
   [Malhotra, A.] Univ So Calif, Div Pulm & Crit Care, La Jolla, CA USA.
C3 University of Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV);
   University of Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV);
   University of Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV);
   University of Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV);
   University of Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV);
   University of Lausanne; University of Lausanne; University of Southern
   California
RP Heinzer, R (corresponding author), Univ Lausanne, Univ Lausanne Hosp, Ctr Invest & Res Sleep, CH-1011 Lausanne, Switzerland.
EM raphael.heinzer@chuv.ch
RI Marti-Soler, Helena/AAA-7659-2019; Preisig, Martin/H-3441-2016;
   Vollenweider, Peter/Q-4603-2016; Tafti, Mehdi/A-8887-2017;
   Marques-Vidal, Pedro/C-9449-2009
OI Heinzer, Raphael/0000-0002-3215-7788; Vollenweider,
   Peter/0000-0002-0765-896X; Tafti, Mehdi/0000-0002-6997-3914;
   Marti-Soler, Helena/0000-0002-7127-205X; Waeber,
   Gerard/0000-0003-4193-788X; haba-rubio, jose/0000-0001-7466-6436;
   Preisig, Martin/0000-0001-5689-4259; Marques-Vidal,
   Pedro/0000-0002-4548-8500
FU Faculty of Biology and Medicine of Lausanne, Lausanne University
   Hospital; Swiss National Science Foundation; Leenaards Foundation;
   GlaxoSmithKline; Ligue Pulmonaire Vaudoise
FX Faculty of Biology and Medicine of Lausanne, Lausanne University
   Hospital, Swiss National Science Foundation, Leenaards Foundation,
   GlaxoSmithKline, Ligue Pulmonaire Vaudoise.
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NR 34
TC 1731
Z9 1808
U1 5
U2 150
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 2213-2600
J9 LANCET RESP MED
JI Lancet Resp. Med.
PD APR
PY 2015
VL 3
IS 4
BP 310
EP 318
DI 10.1016/S2213-2600(15)00043-0
PG 9
WC Critical Care Medicine; Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Respiratory System
GA CG2BD
UT WOS:000353079000022
PM 25682233
OA Green Submitted, Green Accepted
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Chong, KS
   Chang, YH
   Yang, CT
   Chou, CK
   Ou, H
   Kuo, SH
AF Chong, Kah Suan
   Chang, Yi-Hsin
   Yang, Chun-Ting
   Chou, Chu-Kuang
   Ou, Huang-Tz
   Kuo, Shihchen
TI Longitudinal economic burden of incident complications among metabolic
   syndrome populations
SO CARDIOVASCULAR DIABETOLOGY
LA English
DT Article
DE Metabolic syndrome; Cardiovascular disease; Complications; Microvascular
   disease; Cancer; Cost
ID HEALTH-CARE COSTS; CARDIOVASCULAR-DISEASE; OBESITY; RISK; PREVALENCE;
   TAIWAN
AB BackgroundThis study quantifies the longitudinal economic burden for a wide spectrum of incident complications, metabolic syndrome (MS)-related risk factors, and comorbidities in patients with MS.MethodsThis retrospective study utilized linked data from the 2013 National Health Interview Survey and the 2012-2021 National Health Insurance Research Database to identify MS individuals and their characteristics. The incidence rate of each complication was calculated as the number of complication events in the study period divided by the total person-years during follow-up. The healthcare costs of complications were analyzed using a generalized estimating equation model to determine the cost impact of complications after adjustment for patients' characteristics. Sensitivity analyses on variables with high missing rates (i.e., cause of death, body mass index) were performed.ResultsAmong 837 identified MS individuals over 8.28 (+/- 1.35) years of follow-up, the most frequent complications were microvascular diseases (incidence rate for nephropathy/retinopathy/neuropathy: 6.49/2.64/2.08 events per 100 person-years), followed by cardiovascular diseases (2.47), peripheral vascular diseases (2.01), and cancers (1.53). Death was the costliest event (event-year cost per person: USD 16,429) and cancers were the most expensive complications (USD 9,127-11,083 for non-MS- and MS-related cancers). Developing non-MS/MS-related cancers, cardiovascular diseases, and obesity-related medical conditions increased annual costs by 273% (95% CI: 181-397%)/175% (105-269%), 159% (118-207%), and 140% (84-214%), respectively. Microvascular diseases had the lowest cost impact on annual costs (i.e., 27% [17-39%]/27% [11-46%]/24% [11-37%] increases for nephropathy/neuropathy/retinopathy, respectively). Having existing comorbidities increased annual costs by 20% (osteoarthritis) to 108% (depression). Having morbid obesity (i.e., body mass index >= 35 kg/m2) increased annual costs by 58% (30-91%).ConclusionsThe economic burden from costly incident complications (i.e., cardiovascular diseases, peripheral vascular diseases, cancers), MS-related risk factors (i.e., morbid obesity), and comorbidities (i.e., depression) highlight the urgent need for early intervention to prevent MS and its progression. The comprehensive cost estimates reported in this study can facilitate the parameterization of economic analyses to identify cost-effective interventions for these patients.
C1 [Chong, Kah Suan; Chang, Yi-Hsin; Yang, Chun-Ting; Ou, Huang-Tz; Kuo, Shihchen] Natl Cheng Kung Univ, Inst Clin Pharm & Pharmaceut Sci, Coll Med, Tainan, Taiwan.
   [Chang, Yi-Hsin; Ou, Huang-Tz] Natl Cheng Kung Univ, Coll Med, Dept Pharm, Tainan, Taiwan.
   [Yang, Chun-Ting] Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Div Pharmacoepidemiol & Pharmacoecon, Boston, MA USA.
   [Chou, Chu-Kuang] Chia Yi Christian Hosp, Ditmanson Med Fdn Chia, Dept Internal Med, Div Gastroenterol & Hepatol, Chiayi, Taiwan.
   [Chou, Chu-Kuang] Chia Yi Christian Hosp, Ditmanson Med Fdn, Obes Ctr, Chiayi, Taiwan.
   [Kuo, Shihchen] Univ Michigan, Med Sch, Dept Internal Med, Div Metab Endocrinol & Diabet, Ann Arbor, MI USA.
C3 National Cheng Kung University; National Cheng Kung University; Harvard
   University; Harvard University Medical Affiliates; Brigham & Women's
   Hospital; Harvard Medical School; University of Michigan System;
   University of Michigan
RP Ou, H (corresponding author), Natl Cheng Kung Univ, Coll Med, Dept Pharm, Tainan, Taiwan.
EM huangtz@mail.ncku.edu.tw
RI hu, cheng/AAY-5956-2021; Chou, Chu-kuang/AAF-5875-2020
OI Yang, Chun-Ting/0000-0002-5747-6806
FU Ministry of Science and Technology, Taiwan
FX The authors are grateful to the Data Science Center, National Cheng Kung
   University Hospital, for providing administrative and technical support.
   We'd like to thank Adam Przywecki for proofreading the manuscript.
CR Al-Omar HA, 2023, ADV THER, V40, P1430, DOI 10.1007/s12325-023-02426-z
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NR 37
TC 6
Z9 6
U1 0
U2 2
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1475-2840
J9 CARDIOVASC DIABETOL
JI Cardiovasc. Diabetol.
PD JUL 10
PY 2024
VL 23
IS 1
AR 246
DI 10.1186/s12933-024-02335-7
PG 10
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism
GA YQ7G8
UT WOS:001270008600002
PM 38987782
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Moyo-Chilufya, M
   Maluleke, K
   Kgarosi, K
   Muyoyeta, M
   Hongoro, C
   Musekiwa, A
AF Moyo-Chilufya, Maureen
   Maluleke, Kuhlula
   Kgarosi, Kabelo
   Muyoyeta, Monde
   Hongoro, Charles
   Musekiwa, Alfred
TI The burden of non-communicable diseases among people living with HIV in
   Sub-Saharan Africa: a systematic review and meta-analysis
SO ECLINICALMEDICINE
LA English
DT Review
DE Non-communicable diseases; People living with HIV; Sub-Saharan Africa;
   HIV/AIDS; Systematic review; Meta-analysis
ID HUMAN-IMMUNODEFICIENCY-VIRUS; INITIATING ANTIRETROVIRAL THERAPY; MAJOR
   DEPRESSIVE DISORDER; PUBLIC-HEALTH FACILITIES; TYPE-2 DIABETES-MELLITUS;
   ART-NAIVE PATIENTS; RISK-FACTORS; METABOLIC SYNDROME; INFECTED PATIENTS;
   POSITIVE INDIVIDUALS
AB Background Non-communicable diseases (NCDs) are increasing among people living with HIV (PLHIV), especially in Sub-Saharan Africa (SSA). We determined the prevalence of NCDs and NCD risk factors among PLHIV in SSA to inform health policy makers.Methods We conducted a systematic review and meta-analysis on the prevalence of NCDs and risk factors among PLHIV in SSA. We comprehensively searched PubMed/MEDLINE, Scopus, and EBSCOhost (CINAHL) electronic databases for sources published from 2010 to July 2023. We applied the random effects meta-analysis model to pool the results using STATA. The systematic review protocol was registered on PROSPERO (registration number: CRD42021258769).Findings We included 188 studies from 21 countries in this meta-analysis. Our findings indicate pooled prevalence estimates for hypertension (20.1% [95% CI:17.5-22.7]), depression (30.4% [25.3-35.4]), diabetes (5.4% [4.4-6.4]), cervical cancer (1.5% [0.1-2.9]), chronic respiratory diseases (7.1% [4.0-10.3]), overweight/obesity (32.2% [29.7-34.7]), hypercholesterolemia (21.3% [16.6-26.0]), metabolic syndrome (23.9% [19.5-28.7]), alcohol consumption (21.3% [17.9-24.6]), and smoking (6.4% [5.2-7.7]).Interpretation People living with HIV have a high prevalence of NCDs and their risk factors including hypertension, depression, overweight/obesity, hypercholesterolemia, metabolic syndrome and alcohol consumption. We recom-mend strengthening of health systems to allow for improved integration of NCDs and HIV services in public health facilities in SSA. NCD risk factors such as obesity, hypercholesterolemia, and alcohol consumption can be addressed through health promotion campaigns. There is a need for further research on the burden of NCDs among PLHIV in most of SSA. Copyright (c) 2023 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
C1 [Moyo-Chilufya, Maureen; Maluleke, Kuhlula; Kgarosi, Kabelo; Hongoro, Charles; Musekiwa, Alfred] Univ Pretoria, Fac Hlth Sci, Sch Hlth Syst & Publ Hlth, Pretoria, South Africa.
   [Muyoyeta, Monde] Ctr Infect Dis Res Zambia, Lusaka, Zambia.
   [Hongoro, Charles] Human Sci Res Council, Pretoria, South Africa.
   [Musekiwa, Alfred] Fac Hlth Sci, 31 Room 5-10,Level 5,HW Snyman Bldg North,Bophel, ZA-0084 Pretoria, South Africa.
C3 University of Pretoria; Human Sciences Research Council-South Africa
RP Musekiwa, A (corresponding author), Fac Hlth Sci, 31 Room 5-10,Level 5,HW Snyman Bldg North,Bophel, ZA-0084 Pretoria, South Africa.
EM Alfred.Musekiwa@up.ac.za
RI Chilufya, Maureen/LRB-6846-2024; Musekiwa, Alfred/IUP-3659-2023
OI Kgarosi, Kabelo/0000-0003-4236-3339; Musekiwa,
   Alfred/0000-0001-5880-3680; Hongoro, Charles/0000-0002-9715-4940; Moyo -
   Chilufya, Maureen/0000-0003-2312-0972
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NR 207
TC 31
Z9 31
U1 0
U2 5
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
EI 2589-5370
J9 ECLINICALMEDICINE
JI EClinicalMedicine
PD NOV
PY 2023
VL 65
AR 102255
DI 10.1016/j.eclinm.2023.102255
EA OCT 2023
PG 26
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA U9WS8
UT WOS:001088244700001
PM 37842552
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Usharani, P
   Merugu, PL
   Nutalapati, C
AF Usharani, Pingali
   Merugu, Padma Latha
   Nutalapati, Chandrasekhar
TI Evaluation of the effects of a standardized aqueous extract of
   Phyllanthus emblica fruits on endothelial dysfunction, oxidative stress,
   systemic inflammation and lipid profile in subjects with metabolic
   syndrome: a randomised, double blind, placebo controlled clinical study
SO BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Article
DE Phyllanthus emblica; Emblica officinalis; Amla; Reflection index;
   Dyslipidemia; Oxidative stress; Systemic inflammation; Endothelial
   dysfunction
ID OFFICINALIS GAERTN.; BIOMARKERS; RISK
AB BackgroundEndothelial dysfunction (ED) has been observed in individuals with metabolic syndrome (MetS) and contributes to the initiation and progression of atherosclerosis. The primary management of MetS involves lifestyle modifications and treatment of its individual components with drugs all of which have side effects. Thus, it would be of advantageous if natural products would be used as adjuncts or substitutes for conventional drugs. The aim of the present study was to evaluate the effect of standardized aqueous extract of fruits of Phyllanthus emblica (P. emblica) 250mg and 500mg twice daily on ED, oxidative stress, systemic inflammation and lipid profile in subjects with MetS.MethodsIn this randomised, double-blind, placebo-controlled clinical study endothelial function was measured by calculating reflection index (RI) using digital plethysmograph. Oxidative stress biomarkers used were nitric oxide (NO), glutathione (GSH) and malondialdehyde (MDA). Systemic inflammation was measured by determining high sensitivity C-reactive protein (hsCRP) and dyslipidemia by lipid profile. ANOVA, paired and unpaired t-test were used. P-value <0.05 was considered statistically significant.ResultsOut of 65 screened subjects all 59 enrolled completed the study. P. emblica aqueous extract (PEE), 250mg and 500mg twice daily dosing, showed significant reduction in mean RI, measure of endothelial function, at 8 and 12weeks (p<0.001) compared to baseline and placebo. Significant mean % change was seen in oxidative stress biomarkers, NO (+41.89%, +50.7%), GSH (+24.31%, +53.22%) and MDA (-21.02%, -31.44%), and systemic inflammation biomarker, hsCRP (-39.68%, -53.77%) (p<0.001) at 12weeks with 250mg and 500mg twice daily dosage respectively. Significant mean % change was also seen at 12weeks with TC (-7.71%, -11.11%), HDL-C (+7.33% +22.16%, p<0.05), LDL-C (-11.39%, -21.8%) and TG (-9.81%, -19.22%) respectively with 250mg and 500mg twice daily (p<0.001). PEE 500mg twice daily was significantly more efficacious than the 250mg twice daily and placebo. No participant discontinued the study because of adverse events.ConclusionsP.emblica aqueous extract significantly improved endothelial function, oxidative stress, systemic inflammation and lipid profile at both dosages tested, but especially at 500mg twice daily. Thus, this product may be used as an adjunct to conventional therapy (lifestyle modification and pharmacological intervention) in the management of metabolic syndrome.Trial registrationThis study was registered with Clinical Trials Registry - India (CTRI) with the registration number of CTRI/2017/09/009606. The study was registered retrospectively on 4th September 2017.
C1 [Usharani, Pingali; Merugu, Padma Latha; Nutalapati, Chandrasekhar] Nizams Inst Med Sci, Dept Pharmacol & Therapeut, Hyderabad, Telangana, India.
C3 Nizam's Institute of Medical Sciences
RP Usharani, P (corresponding author), Nizams Inst Med Sci, Dept Pharmacol & Therapeut, Hyderabad, Telangana, India.
EM ushapingali@yahoo.com
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NR 34
TC 37
Z9 42
U1 0
U2 5
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1472-6882
J9 BMC COMPLEM ALTERN M
JI BMC Complement. Altern. Med.
PD MAY 6
PY 2019
VL 19
AR 97
DI 10.1186/s12906-019-2509-5
PG 8
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA HX2HQ
UT WOS:000467213300002
PM 31060549
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Dearing, C
   Handa, RJ
   Myers, B
AF Dearing, Carley
   Handa, Robert J.
   Myers, Brent
TI Sex differences in autonomic responses to stress: implications for
   cardiometabolic physiology
SO AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
LA English
DT Review
DE androgen; autonomic balance; chronic stress; estrogen; glucocorticoid
ID ESTROGEN-RECEPTOR-ALPHA; CORTICOTROPIN-RELEASING HORMONE; MAJOR
   DEPRESSIVE DISORDER; SOCIOECONOMIC-STATUS; FEMALE RATS; PARAVENTRICULAR
   NUCLEUS; VASCULAR DYSFUNCTION; METABOLIC SYNDROME; ANDROGEN RECEPTOR;
   ALLOSTATIC LOAD
AB Chronic stress is a significant risk factor for negative health outcomes. Furthermore, imbalance of autonomic nervous system control leads to dysregulation of physiological responses to stress and contributes to the pathogenesis of cardiometabolic and psychiatric disorders. However, research on autonomic stress responses has historically focused on males, despite evidence that females are disproportionality affected by stress-related disorders. Accordingly, this mini-review focuses on the influence of biological sex on autonomic responses to stress in humans and rodent models. The reviewed literature points to sex differences in the consequences of chronic stress, including cardiovascular and metabolic disease. We also explore basic rodent studies of sex-specific autonomic responses to stress with a focus on sex hormones and hypothalamic-pituitary-adrenal axis regulation of cardiovascular and metabolic physiology. Ultimately, emerging evidence of sex differences in autonomic-endocrine integration highlights the importance of sex-specific studies to understand and treat cardiometabolic dysfunction.
C1 [Dearing, Carley; Handa, Robert J.; Myers, Brent] Colorado State Univ, Dept Biomed Sci, Ft Collins, CO 80523 USA.
C3 Colorado State University System; Colorado State University Fort Collins
RP Myers, B (corresponding author), Colorado State Univ, Dept Biomed Sci, Ft Collins, CO 80523 USA.
EM brent.myers@colostate.edu
FU NIH [F30 OD032120, R01 DK105826, R01 HL150559]
FX GRANTS This study was supported by NIH grants F30 OD032120 (to C.D.) ,
   R01 DK105826 (to R.J.H.) , and R01 HL150559 (to B.M.) .
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NR 136
TC 18
Z9 20
U1 2
U2 7
PU AMER PHYSIOLOGICAL SOC
PI Rockville
PA 6120 Executive Blvd, Suite 600, Rockville, MD, UNITED STATES
SN 0193-1849
EI 1522-1555
J9 AM J PHYSIOL-ENDOC M
JI Am. J. Physiol.-Endocrinol. Metab.
PD SEP
PY 2022
VL 323
IS 3
BP E281
EP E289
DI 10.1152/ajpendo.00058.2022
PG 9
WC Endocrinology & Metabolism; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Physiology
GA 6S3FO
UT WOS:000892877100008
PM 35793480
OA Green Published
DA 2025-06-11
ER

PT J
AU Mulero, J
   Zafrilla, P
   Martinez-Cacha, A
AF Mulero, J.
   Zafrilla, P.
   Martinez-Cacha, A.
TI Oxidative stress, frailty and cognitive decline
SO JOURNAL OF NUTRITION HEALTH & AGING
LA English
DT Article
DE Frailty; oxidative stress; decline cognitive
ID OLDER MEXICAN-AMERICANS; ALZHEIMERS-DISEASE; CARDIOVASCULAR HEALTH;
   METABOLIC SYNDROME; GENE-EXPRESSION; BRAIN; INFLAMMATION; INTERLEUKIN-6;
   MARKERS; ADULTS
AB The causes of frailty are complex and must be accepted as multidimensional based on the interplay of genetic, biological, physical, psychological, social and environmental factors, although inflammation and oxidative stress are two factors that play an important role in the development of symptoms with those fragile states.
   To establish the relationship between oxidative stress, frailty and decline cognitive.
   A review of the literature and data abstraction from papers are showing the relationship between a) oxidative stress and frailty, b) oxidative stress and decline cognitive.
   The papers reviewed showed that we can establish a relationship between the progress of neurodegenerative disorders and increased oxidative stress. Also found in frailty, that oxidative stress plays an important role as one of the starting points for the appearance of permanent inflammatory states.
   Although the literature indicates the relationship between oxidative stress, frailty and decline cognitive, more studies are needed in this regard, especially interventions that asses whether increased intake of antioxidants in older frailty may improve the progress of disease and slow cognitive decline.
C1 [Mulero, J.; Zafrilla, P.; Martinez-Cacha, A.] Catholic Univ San Antonio, Dept Food Technol & Nutr, Murcia 30107, Spain.
C3 Universidad Catolica de Murcia
RP Mulero, J (corresponding author), Catholic Univ San Antonio, Dept Food Technol & Nutr, Murcia 30107, Spain.
EM jmulero@pdi.ucam.edu
RI Zafrilla, Pilar/JAN-5983-2023
OI ZAFRILLA, PILAR/0000-0002-1463-7120
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NR 61
TC 125
Z9 134
U1 0
U2 40
PU SPRINGER FRANCE
PI PARIS
PA 22 RUE DE PALESTRO, PARIS, 75002, FRANCE
SN 1279-7707
EI 1760-4788
J9 J NUTR HEALTH AGING
JI J. Nutr. Health Aging
PD NOV
PY 2011
VL 15
IS 9
BP 756
EP 760
DI 10.1007/s12603-011-0130-5
PG 5
WC Geriatrics & Gerontology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology; Nutrition & Dietetics
GA 856US
UT WOS:000297669700004
PM 22089224
OA hybrid
DA 2025-06-11
ER

PT J
AU Wan, C
   Su, H
   Zhang, C
AF Wan, Cheng
   Su, Hua
   Zhang, Chun
TI Role of NADPH Oxidase in Metabolic Disease-Related Renal Injury: An
   Update
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Review
ID CHRONIC KIDNEY-DISEASE; OXYGEN SPECIES PRODUCTION; OXIDATIVE STRESS;
   ANGIOTENSIN-II; URIC-ACID; ENDOTHELIAL DYSFUNCTION; GLOMERULAR INJURY;
   PODOCYTE INJURY; HIGH GLUCOSE; FIBRONECTIN EXPRESSION
AB Metabolic syndrome has been linked to an increased risk of chronic kidney disease. The underlying pathogenesis of metabolic disease-related renal injury remains obscure. Accumulating evidence has shown that NADPH oxidase is a major source of intrarenal oxidative stress and is upregulated by metabolic factors leading to overproduction of ROS in podocytes, endothelial cells, and mesangial cells in glomeruli, which is closely associated with the initiation and progression of glomerular diseases. This review focuses on the role of NADPH oxidase-induced oxidative stress in the pathogenesis of metabolic disease-related renal injury. Understanding of the mechanism may help find potential therapeutic strategies.
C1 [Wan, Cheng; Su, Hua; Zhang, Chun] Huazhong Univ Sci & Technol, Tongji Med Coll, Union Hosp, Dept Nephrol, Wuhan 430022, Hubei, Peoples R China.
C3 Huazhong University of Science & Technology
RP Zhang, C (corresponding author), Huazhong Univ Sci & Technol, Tongji Med Coll, Union Hosp, Dept Nephrol, Wuhan 430022, Hubei, Peoples R China.
EM drzhangchun@hust.edu.cn
RI ZHANG, CHUN/HLH-6523-2023
OI Zhang, Chun/0000-0003-3565-8024
FU National Natural Science Foundation of China [81170662, 31200872,
   81470964, 81570671, 81522010]; Wuhan Science and Technology Bureau
   [2015060101010039]; Specialized Research Fund for the Doctoral Program
   of Higher Education of China [20130142110064]
FX This work was supported by grants from the National Natural Science
   Foundation of China (no. 81170662, no. 31200872, no. 81470964, no.
   81570671, and no. 81522010), a grant from Wuhan Science and Technology
   Bureau (no. 2015060101010039), and Specialized Research Fund for the
   Doctoral Program of Higher Education of China (no. 20130142110064).
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NR 105
TC 38
Z9 45
U1 0
U2 9
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PY 2016
VL 2016
AR 7813072
DI 10.1155/2016/7813072
PG 8
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA DU2ZK
UT WOS:000382080000001
PM 27597884
OA Green Published, Green Submitted, hybrid
DA 2025-06-11
ER

PT J
AU Azab, SS
   Hosni, HE
   El Far, TA
   Ismail, NN
   El Bakdady, YK
   Mohamed, AF
AF Azab, Sherif Salah
   Hosni, Hossam El Din
   El Far, Taha A.
   Ismail, Nashaat Nabil
   El Bakdady, Yasser K.
   Mohamed, Ahmed F.
TI The Predictive Value of Arteriogenic Erectile Dysfunction for Coronary
   Artery Disease in Men
SO JOURNAL OF SEXUAL MEDICINE
LA English
DT Article
DE Erectile Dysfunction; Ischemic Heart Disease; Stress
   Electrocardiography; Metabolic Syndrome
ID RISK-FACTORS; ENDOTHELIAL DYSFUNCTION; METABOLIC SYNDROME; TESTOSTERONE;
   PREVALENCE; EVENTS; OLDER; AGE
AB Background: Erectile dysfunction (ED) is assumed to be connected with vascular disease caused by endothelial dysfunction, and characterized by the incapability of the smooth muscle cells lining the arterioles to relax, therefore, inhibit vasodilatation.
   Aim: To assess the predictive value of arteriogenic ED for coronary artery disease in men above the age of 40 years.
   Methods: 75 Patients reporting arteriogenic ED and 25 men with normal erectile function were enrolled in the study. Both patients and controls were subjected to the following investigations: lipid profile, fasting blood sugar, body mass index (BMI), waist circumference, penile duplex study, stress electrocardiography (ECG) test, International Index of Erectile Function (IIEF) Type 5 (Arabic version), and cardiovascular (CV) 10-year risk assessment using Framingham and Prospective Cardiovascular Munster (PROCAM) scoring systems.
   Outcomes: We compare between the study groups regarding the interpretation of exercise testing.
   Results: We observed significant increase in the mean value of age, systolic blood pressure, BMI, weight, height, and waist circumference in the cases; significant prevalence of obesity and overweight in the cases (P < .001); significant increase in the mean value of total cholesterol, triglycerides (TG), and low-density lipoprotein; and decrease in mean value of high-density lipoprotein in the cases (P < .001). Additionally, there was high incidence of positive stress ECG in the cases (25.3%) vs that in controls (12%), and significant difference between patients with positive stress ECG test and those with negative stress ECG test regarding their lipid profile, age, BMI, and waist circumference with higher values in positive stress ECG for total cholesterol, TG, and low-density lipoprotein, and lower value for high-density lipoprotein (P < .001). According to PROCAM and Framingham scoring systems 10-year risk assessment, there was a high significant difference between the cases and control groups with a higher score in cases than the control group with 30.7% of cases having >= 30% risk of developing coronary heart disease, and significant positive correlations between CV risk and BMI, and negative correlations with IIEF-5 cases (P < .001).
   Clinical Translation: Ischemic heart disease events were higher in men with documented arteriogenic ED than those without ED.
   Conclusions: All items of metabolic syndrome were investigated and analyzed and we evaluated our groups using both PROCAM and Framingham scoring system. An exercise ECG is suggested before starting treatment of vasculogenic ED at least in patients with CV risk factors. Copyright (C) 2018, International Society for Sexual Medicine. Published by Elsevier Inc. All rights reserved.
C1 [Azab, Sherif Salah] October 6 Univ, Fac Med, Urol Dept, 7 el Gazal Wa el Nasseg,Lebanon Sq, Cairo 12411, Egypt.
   [Hosni, Hossam El Din] Cairo Univ, Fac Med, Androl Dept, Cairo, Egypt.
   [El Far, Taha A.] Cairo Univ, Fac Med, Cairo, Egypt.
   [Ismail, Nashaat Nabil] Beni Suef Univ, Fac Med, Androl Dept, Bani Suwayf, Egypt.
   [El Bakdady, Yasser K.] Cairo Univ, Fac Med, Cardiol Dept, Cairo, Egypt.
   [Mohamed, Ahmed F.] Cairo Univ, Fac Med, Androl & Sexually Transmitted Dis Dept, Cairo, Egypt.
C3 Egyptian Knowledge Bank (EKB); October 6 University (O6U); Egyptian
   Knowledge Bank (EKB); Cairo University; Egyptian Knowledge Bank (EKB);
   Cairo University; Egyptian Knowledge Bank (EKB); Beni Suef University;
   Egyptian Knowledge Bank (EKB); Cairo University; Egyptian Knowledge Bank
   (EKB); Cairo University
RP Azab, SS (corresponding author), October 6 Univ, Fac Med, Urol Dept, 7 el Gazal Wa el Nasseg,Lebanon Sq, Cairo 12411, Egypt.
EM ssazab@yahoo.com
RI Azab, Sherif/G-1712-2016
OI Azab, Sherif/0000-0003-1879-9343
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NR 33
TC 6
Z9 7
U1 0
U2 8
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1743-6095
EI 1743-6109
J9 J SEX MED
JI J. Sex. Med.
PD JUN
PY 2018
VL 15
IS 6
BP 880
EP 887
DI 10.1016/j.jsxm.2018.04.639
PG 8
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA GH4ZA
UT WOS:000433423700011
PM 29759909
DA 2025-06-11
ER

PT J
AU Poulios, E
   Koukounari, S
   Psara, E
   Vasios, GK
   Sakarikou, C
   Giaginis, C
AF Poulios, Efthymios
   Koukounari, Stergia
   Psara, Evmorfia
   Vasios, Georgios K.
   Sakarikou, Christina
   Giaginis, Constantinos
TI Anti-obesity Properties of Phytochemicals: Highlighting their Molecular
   Mechanisms against Obesity
SO CURRENT MEDICINAL CHEMISTRY
LA English
DT Review
DE Phytochemicals; obesity; metabolism; metabolic diseases; inflammation;
   oxidative stress; molecular mechanisms
ID HIGH-FAT-DIET; CONJUGATED LINOLEIC-ACID; WHITE ADIPOSE-TISSUE;
   DOSE-RESPONSE METAANALYSIS; INDUCED INSULIN-RESISTANCE; DOUBLE-BLIND;
   METABOLIC SYNDROME; HEPATIC STEATOSIS; REDUCES OBESITY; BERBERINE
   SUPPLEMENTATION
AB Obesity is a complex, chronic and inflammatory disease that affects more than one-third of the world's population, leading to a higher incidence of diabetes, dyslipidemia, metabolic syndrome, cardiovascular diseases, and some types of cancer. Several phytochemicals are used as flavoring and aromatic compounds, also exerting many benefits for public health. This study aims to summarize and scrutinize the beneficial effects of the most important phytochemicals against obesity. Systematic research of the current international literature was carried out in the most accurate scientific databases, e.g., Pubmed, Scopus, Web of Science and Google Scholar, using a set of critical and representative keywords, such as phytochemicals, obesity, metabolism, metabolic syndrome, etc. Several studies unraveled the potential positive effects of phytochemicals such as berberine, carvacrol, curcumin, quercetin, resveratrol, thymol, etc., against obesity and metabolic disorders. Mechanisms of action include inhibition of adipocyte differentiation, browning of the white adipose tissue, inhibition of enzymes such as lipase and amylase, suppression of inflammation, improvement of the gut microbiota, and downregulation of obesity-inducing genes. In conclusion, multiple bioactive compounds-phytochemicals exert many beneficial effects against obesity. Future molecular and clinical studies must be performed to unravel the multiple molecular mechanisms and anti-obesity activities of these naturally occurring bioactive compounds.
C1 [Poulios, Efthymios; Koukounari, Stergia; Psara, Evmorfia; Vasios, Georgios K.; Sakarikou, Christina; Giaginis, Constantinos] Univ Aegean, Sch Environm, Dept Food Sci & Nutr, Myrina, Lemnos, Greece.
RP Giaginis, C (corresponding author), Univ Aegean, Sch Environm, Dept Food Sci & Nutr, Myrina, Lemnos, Greece.
EM epoulios@aegean.gr
RI Giaginis, Constantinos/JMQ-9552-2023; Poulios, Efthymios/HSH-0842-2023
FU Declared none.
FX Declared none.
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PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 0929-8673
EI 1875-533X
J9 CURR MED CHEM
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PY 2024
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DI 10.2174/0929867330666230517124033
PG 37
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Pharmacology &
   Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
GA R8WL9
UT WOS:001067103100004
PM 37198988
DA 2025-06-11
ER

PT J
AU Lemos, GD
   Torrinhas, RS
   Waitzberg, DL
AF Lemos, Gabriela de Oliveira
   Torrinhas, Raquel Susana
   Waitzberg, Dan Linetzky
TI Nutrients, Physical Activity, and Mitochondrial Dysfunction in the
   Setting of Metabolic Syndrome
SO NUTRIENTS
LA English
DT Review
DE metabolic syndrome; mitochondrial function; sphingolipids; ceramides;
   diet; exercise
ID MEDIUM-CHAIN TRIGLYCERIDES; FATTY LIVER-DISEASE; SWEETENED BEVERAGE
   CONSUMPTION; SKELETAL-MUSCLE CELLS; VIRGIN OLIVE OIL;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; COCONUT OIL; DIABETES-MELLITUS;
   HEPATIC STEATOSIS
AB Metabolic syndrome (MetS) is a cluster of metabolic risk factors for diabetes, coronary heart disease, non-alcoholic fatty liver disease, and some tumors. It includes insulin resistance, visceral adiposity, hypertension, and dyslipidemia. MetS is primarily linked to lipotoxicity, with ectopic fat deposition from fat storage exhaustion, more than obesity per se. Excessive intake of long-chain saturated fatty acid and sugar closely relates to lipotoxicity and MetS through several pathways, including toll-like receptor 4 activation, peroxisome proliferator-activated receptor-gamma regulation (PPAR gamma), sphingolipids remodeling, and protein kinase C activation. These mechanisms prompt mitochondrial dysfunction, which plays a key role in disrupting the metabolism of fatty acids and proteins and in developing insulin resistance. By contrast, the intake of monounsaturated, polyunsaturated, and medium-chain saturated (low-dose) fatty acids, as well as plant-based proteins and whey protein, favors an improvement in sphingolipid composition and metabolic profile. Along with dietary modification, regular exercises including aerobic, resistance, or combined training can target sphingolipid metabolism and improve mitochondrial function and MetS components. This review aimed to summarize the main dietary and biochemical aspects related to the physiopathology of MetS and its implications for mitochondrial machinery while discussing the potential role of diet and exercise in counteracting this complex clustering of metabolic dysfunctions.
C1 [Lemos, Gabriela de Oliveira; Torrinhas, Raquel Susana; Waitzberg, Dan Linetzky] Univ Sao Paulo, Dept Gastroenterol, Lab Nutr & Metab Surg Digest Tract LIM 35, Sch Med FMUSP, Av Dr Arnaldo 455,2 andar,sala 2208, BR-01246903 Sao Paulo, SP, Brazil.
C3 Universidade de Sao Paulo
RP Lemos, GD (corresponding author), Univ Sao Paulo, Dept Gastroenterol, Lab Nutr & Metab Surg Digest Tract LIM 35, Sch Med FMUSP, Av Dr Arnaldo 455,2 andar,sala 2208, BR-01246903 Sao Paulo, SP, Brazil.
EM dra.golemos@gmail.com
RI Torrinhas, Raquel/AAH-4722-2019
OI De Oliveira Lemos, Gabriela/0000-0003-0943-1387; Waitzberg,
   Dan/0000-0002-9196-9372
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NR 163
TC 17
Z9 18
U1 1
U2 17
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD MAR
PY 2023
VL 15
IS 5
AR 1217
DI 10.3390/nu15051217
PG 19
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 9T4EM
UT WOS:000946981300001
PM 36904216
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Cattafesta, M
   Salaroli, LB
AF Cattafesta, Monica
   Salaroli, Luciane Bresciani
TI Diets high in vegetables, fruits, cereals, and tubers as a protective
   factor for metabolic syndrome in bank employees
SO DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
LA English
DT Article
DE metabolic syndrome; dietary patterns; food consumption; workers; bank
   employees
ID INSULIN-RESISTANCE; NATIONAL-HEALTH; PATTERNS; PREVALENCE; STRESS;
   ASSOCIATION; VITORIA
AB Background: The prevalence of metabolic syndrome (MetS) is increasing, and its development may be related to westernized diets and working conditions.
   Purpose: The purpose of this study was to evaluate the association of dietary patterns in bank employees with the presence of MetS, considering sociodemographic and behavioral factors as well as laboratory tests.
   Subjects and methods: This was a cross-sectional study of 515 bankers. Sociodemographic, occupational, behavioral, and food consumption data were collected. Dietary patterns were determined by principal component analysis with orthogonal varimax rotation.
   Results: The dietary pattern of vegetables, fruits, cereals, and tubers was correlated with the presence of MetS and with waist circumference measurements and triglyceride levels. Individuals in the third and fifth quintiles of the pattern "vegetables, fruits, cereals, and tubers" presented with 3.28 and 2.24 times less chances of MetS when compared to individuals in the first quintile of this dietary pattern (OR 0.30, 95% CI 0.13-0.67, and OR 0.44, 95% CI 0.21-0.92, respectively). Subjects over 45 years of age were almost twice as likely to develop MetS (OR 1.95, 95% CI 1.01-3.77).
   Conclusion: Healthy eating represented by the dietary pattern "vegetables, fruits, cereals, and tubers" was associated with better health among bank employees, especially when evaluating competing metabolic complications such as MetS.
C1 [Cattafesta, Monica] Univ Fed Espirito Santo, Postgrad Program Publ Hlth, Vitoria, Espirito Santo, Brazil.
   [Salaroli, Luciane Bresciani] Univ Fed Espirito Santo, Postgrad Program Publ Hlth, Postgrad Program Nutr & Hlth, Dept Hlth Integrated Educ, Vitoria, Espirito Santo, Brazil.
C3 Universidade Federal do Espirito Santo; Universidade Federal do Espirito
   Santo
RP Salaroli, LB (corresponding author), Univ Fed Espirito Santo, Dept Hlth Integrated Educ, Marechal Campos Ave,1468,Maruipe, BR-29047105 Vitoria, ES, Brazil.
EM lucianebresciani@gmail.com
RI Salaroli, Luciane/Z-1241-2018; Cattafesta, Monica/KIB-7830-2024
OI Cattafesta, Monica/0000-0002-8973-622X; Salaroli,
   Luciane/0000-0002-1881-0306
FU Foundation for Support to Research and Innovation of Espirito Santo
FX The authors would like to thank the bank for their support in all stages
   of this study and the Foundation for Support to Research and Innovation
   of Espirito Santo for their granted scholarship.
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NR 55
TC 8
Z9 8
U1 1
U2 4
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-7007
J9 DIABET METAB SYND OB
JI Diabetes Metab. Syndr. Obes.
PY 2018
VL 11
BP 781
EP 790
DI 10.2147/DMSO.S184716
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA HB8VI
UT WOS:000451368700001
PM 30538515
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Lee, KS
   Lee, SG
   Kim, EK
   Jin, HJ
   Im, SU
   Lee, HK
   Merchant, AT
   Song, KB
   Choi, YH
AF Lee, Kyeong-Soo
   Lee, Sang Gyu
   Kim, Eun-Kyong
   Jin, Hye-Jung
   Im, Sang-Uk
   Lee, Hee-Kyung
   Merchant, Anwar T.
   Song, Keun-Bae
   Choi, Youn-Hee
TI Metabolic Syndrome Parameters in adolescents may be determinants for the
   future periodontal diseases
SO JOURNAL OF CLINICAL PERIODONTOLOGY
LA English
DT Article
DE adolescent; gingivitis; metabolic syndrome parameters
ID NUTRITION EXAMINATION SURVEY; INSULIN-RESISTANCE; OXIDATIVE STRESS;
   NATIONAL-HEALTH; OBESITY; ASSOCIATION; CHILDREN; PREVALENCE;
   INFLAMMATION; SENSITIVITY
AB AimThe prevalence of metabolic syndrome (MetS) increases even in adolescents. The evidence that MetS is associated with the periodontal diseases in adolescents has been understudied. Therefore, our aim was to assess the association between MetS parameters and gingivitis in adolescents.
   Material and methodsA total of 941 participants (590 boys, 351 girls), aged 12-18years was selected from the Fourth Korea National Health and Nutrition Examination Survey, a cross-sectional and nationally representative survey, which had had information on waist circumference, blood pressure, serum triglyceride, high-density lipoprotein (HDL) cholesterol, and the fasting blood sugar and community periodontal Index (CPI).
   ResultsThe number of positive parameters of MetS showed significant positive correlation with gingivitis; adjusted and crude ORs with one positive parameters of MetS were 1.92 (95% CI: 1.21-3.04) and 1.88(95% CI: 1.28-2.76), respectively. And adjusted OR with three or more positive parameters of MetS was 3.29 (95% CI: 1.24-8.71). Among five parameters of MetS, Low HDL-cholesterol showed significant association with gingivitis (crude OR 2.12, 95% CI 1.20-3.73; adjusted OR 1.96, 95% CI 1.24-3.12).
   ConclusionsHaving more positive parameters of MetS and low HDL-cholesterol parameter had an independent relationship with the prevalence of gingivitis, which may be determinants for the future periodontal diseases even in adolescents.
C1 [Lee, Kyeong-Soo] Yeungnam Univ, Dept Prevent Med & Publ Hlth, Coll Med, Daegu, South Korea.
   [Lee, Sang Gyu] Yonsei Univ, Grad Sch Publ Hlth, Seoul 120749, South Korea.
   [Kim, Eun-Kyong] Kyungpook Natl Univ, Coll Sci & Technol, Dept Dent Hyg, Sangju, South Korea.
   [Jin, Hye-Jung] Dong Eui Univ, Dept Dent Hyg, Pusan, South Korea.
   [Im, Sang-Uk; Song, Keun-Bae; Choi, Youn-Hee] Kyungpook Natl Univ, Sch Dent, Dept Prevent Dent, Daegu, South Korea.
   [Lee, Hee-Kyung] Yeungnam Univ, Coll Med, Dept Dent, Daegu, South Korea.
   [Merchant, Anwar T.] Univ S Carolina, Arnold Sch Publ Hlth, Dept Epidemiol & Biostat, Columbia, SC 29208 USA.
C3 Yeungnam University; Yonsei University; Yonsei University Health System;
   Kyungpook National University (KNU); Dong-Eui University; Kyungpook
   National University (KNU); Yeungnam University; University of South
   Carolina System; University of South Carolina Columbia
RP Choi, YH (corresponding author), 2177 Dalgubeol Daero, Daegu 700412, South Korea.
EM cyh1001@knu.ac.kr
RI Lee, Seung Eun/ABG-1607-2021; Lee, Sang Gyu/JQV-6912-2023; Merchant,
   Anwar/B-5233-2009
OI Lee, Kyeong Soo/0000-0001-8183-9462; Lee, Sang Gyu/0000-0003-4847-2421;
   IM, sang-uk/0000-0002-1194-9145
FU Basic Science Research Program through the National Research Foundation
   of Korea (NRF) - Ministry of Science, ICT & Future Planning [2013010434]
FX The authors declare that they do not have a conflict of interest. This
   research was supported by Basic Science Research Program through the
   National Research Foundation of Korea (NRF) funded by the Ministry of
   Science, ICT & Future Planning (2013010434).
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NR 43
TC 20
Z9 20
U1 0
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0303-6979
EI 1600-051X
J9 J CLIN PERIODONTOL
JI J. Clin. Periodontol.
PD FEB
PY 2015
VL 42
IS 2
BP 105
EP 112
DI 10.1111/jcpe.12338
PG 8
WC Dentistry, Oral Surgery & Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dentistry, Oral Surgery & Medicine
GA CB7AF
UT WOS:000349777600001
PM 25469423
OA Bronze
DA 2025-06-11
ER

PT J
AU Wagner, JG
   Allen, K
   Yang, HY
   Nan, B
   Morishita, M
   Mukherjee, B
   Dvonch, JT
   Spino, C
   Fink, GD
   Rajagopalan, S
   Sun, QH
   Brook, RD
   Harkema, JR
AF Wagner, James G.
   Allen, Katryn
   Yang, Hui-yu
   Nan, Bin
   Morishita, Masako
   Mukherjee, Bhramar
   Dvonch, J. Timothy
   Spino, Catherine
   Fink, Gregory D.
   Rajagopalan, Sanjay
   Sun, Qinghua
   Brook, Robert D.
   Harkema, Jack R.
TI Cardiovascular Depression in Rats Exposed to Inhaled Particulate Matter
   and Ozone: Effects of Diet-Induced Metabolic Syndrome
SO ENVIRONMENTAL HEALTH PERSPECTIVES
LA English
DT Article
ID HEART-RATE-VARIABILITY; HIGH-FRUCTOSE DIET; AIR-POLLUTION; INSULIN
   SENSITIVITY; HYPERTENSIVE-RATS; HIGH-RISK; INHALATION; PARAMETERS;
   RESPONSES; OBESITY
AB BACKGROUND: High ambient levels of ozone (O-3) and fine particulate matter (PM2.5) are associated with cardiovascular morbidity and mortality, especially in people with pre-existing cardio-pulmonary diseases. Enhanced susceptibility to the toxicity of air pollutants may include individuals with metabolic syndrome (MetS).
   OBJECTIVE: We tested the hypothesis that cardiovascular responses to O-3 and PM2.5 will be enhanced in rats with diet-induced MetS.
   METHODS: Male Sprague-Dawley rats were fed a high-fructose diet (HFrD) to induce MetS and then exposed to O-3, concentrated ambient PM2.5, or the combination of O-3 plus PM2.5 for 9 days. Data related to heart rate (HR), HR variability (HRV), and blood pressure (BP) were collected.
   RESULTS: Consistent with MetS, HFrD rats were hypertensive and insulin resistant, and had elevated fasting levels of blood glucose and triglycerides. Decreases in HR and BP, which were found in all exposure groups, were greater and more persistent in HFrD rats compared with those fed a normal diet (ND). Coexposure to O-3 plus PM2.5 induced acute drops in HR and BP in all rats, but only ND rats adapted after 2 days. HFrD rats had little exposure-related changes in HRV, whereas ND rats had increased HRV during O-3 exposure, modest decreases with PM2.5, and dramatic decreases during O-3 plus PM2.5 coexposures.
   CONCLUSIONS: Cardiovascular depression in O-3- and PM2.5-exposed rats was enhanced and prolonged in rats with HFrD-induced MetS. These results in rodents suggest that people with MetS may be prone to similar exaggerated BP and HR responses to inhaled air pollutants.
C1 [Wagner, James G.; Harkema, Jack R.] Michigan State Univ, Dept Pathobiol & Diagnost Invest, E Lansing, MI 48824 USA.
   [Wagner, James G.; Allen, Katryn; Harkema, Jack R.] Michigan State Univ, Ctr Integrat Toxicol, E Lansing, MI 48824 USA.
   [Yang, Hui-yu; Nan, Bin; Mukherjee, Bhramar; Spino, Catherine] Univ Michigan, Sch Publ Hlth, Dept Biostat, Ann Arbor, MI 48109 USA.
   [Morishita, Masako; Dvonch, J. Timothy] Univ Michigan, Sch Publ Hlth, Dept Environm Hlth Sci, Ann Arbor, MI 48109 USA.
   [Fink, Gregory D.] Michigan State Univ, Dept Pharmacol & Toxicol, E Lansing, MI 48824 USA.
   [Rajagopalan, Sanjay; Sun, Qinghua] Ohio State Univ, Coll Med, Davis Heart & Lung Res Inst, Columbus, OH 43210 USA.
   [Brook, Robert D.] Univ Michigan, Dept Internal Med, Ann Arbor, MI 48109 USA.
C3 Michigan State University; Michigan State University; University of
   Michigan System; University of Michigan; University of Michigan System;
   University of Michigan; Michigan State University; University System of
   Ohio; Ohio State University; University of Michigan System; University
   of Michigan
RP Wagner, JG (corresponding author), Michigan State Univ, 1129 Farm Lane,Room 211, E Lansing, MI 48864 USA.
EM wagnerja@msu.edu
RI Sun, Qinghua/E-4167-2011; Dvonch, Joseph/K-3632-2013
OI Morishita, Masako/0000-0001-9934-2657
FU U.S. EPA STAR Clean Air Research Centers program [R83479701]; National
   Institute of Environmental Health Sciences [P30ES017885] Funding Source:
   NIH RePORTER
FX This project was supported by the U.S. EPA (R83479701) STAR Clean Air
   Research Centers program.
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NR 44
TC 58
Z9 73
U1 1
U2 41
PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE
PI RES TRIANGLE PK
PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233,
   RES TRIANGLE PK, NC 27709-2233 USA
SN 0091-6765
EI 1552-9924
J9 ENVIRON HEALTH PERSP
JI Environ. Health Perspect.
PD JAN
PY 2014
VL 122
IS 1
BP 27
EP 33
DI 10.1289/ehp.1307085
PG 7
WC Environmental Sciences; Public, Environmental & Occupational Health;
   Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health; Toxicology
GA AC6OT
UT WOS:000332644200015
PM 24169565
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Bondia-Pons, I
   Pöhö, P
   Bozzetto, L
   Vetrani, C
   Patti, L
   Aura, AM
   Annuzzi, G
   Hyötyläinen, T
   Rivellese, AA
   Oresic, M
AF Bondia-Pons, Isabel
   Poho, Paivi
   Bozzetto, Lutgarda
   Vetrani, Claudia
   Patti, Lidia
   Aura, Anna-Marja
   Annuzzi, Giovanni
   Hyotylainen, Tuulia
   Rivellese, Angela Albarosa
   Oresic, Matej
TI Isoenergetic diets differing in their n-3 fatty acid and
   polyphenol content reflect different plasma and HDL-fraction lipidomic
   profiles in subjects at high cardiovascular risk
SO MOLECULAR NUTRITION & FOOD RESEARCH
LA English
DT Article
DE Cardiovascular disease; n-3 fatty acids; Lipidomics; Plasmalogens;
   Polyphenols
ID METABOLIC SYNDROME; GREEN TEA; OXIDATIVE STRESS; HEALTH; INFLAMMATION;
   MARKERS; OBESITY
AB Scope: Dysregulation of lipid homeostasis is related to multiple major healthcare problems. The aim of this study was to investigate the effects of n-3 fatty acid (FA) and polyphenol rich diets on plasma and HDL fraction lipidomic profiles in subjects at high cardiovascular risk.
   Methods and results: Ultra performance LC coupled to quadrupole TOF/MS mass spectrometry global lipidomic profiling was applied to plasma and HDL fraction from an 8 wk randomized intervention with four isoenergetic diets, differing in their natural n-3 FA and polyphenols content, in 78 subjects with a high BMI, abdominal obesity, and at least one other feature of the metabolic syndrome. Dependency network analysis showed a different pattern of associations between lipidomics, dietary, and clinical variables after the dietary interventions. The most remarkable associations between variables were observed after the diet high in n-3 FA and polyphenols, as the inverse association between gallic acid intake and LDL cholesterol levels, which was indirectly associated with a HDL cluster exclusively comprised lysophospholipids.
   Conclusion: This is the first human randomized controlled trial showing direct and indirect associations with lipid molecular species and clinical variables of interest in the evaluation of the metabolic syndrome after diets naturally rich in polyphenols.
C1 [Bondia-Pons, Isabel; Poho, Paivi; Aura, Anna-Marja; Hyotylainen, Tuulia; Oresic, Matej] VTT Tech Res Ctr Finland, Espoo, Finland.
   [Bondia-Pons, Isabel] Univ Navarra, Dept Food Sci & Physiol, E-31080 Pamplona, Spain.
   [Bozzetto, Lutgarda; Vetrani, Claudia; Patti, Lidia; Annuzzi, Giovanni; Rivellese, Angela Albarosa] Univ Naples Federico II, Dept Clin Med & Surg, Naples, Italy.
   [Hyotylainen, Tuulia; Oresic, Matej] Steno Diabet Ctr, DK-2820 Gentofte, Denmark.
C3 VTT Technical Research Center Finland; University of Navarra; University
   of Naples Federico II; Steno Diabetes Center
RP Oresic, M (corresponding author), Steno Diabet Ctr, Niels Steensens Vej 2, DK-2820 Gentofte, Denmark.
EM mtjo@steno.dk
RI Bozzetto, Lutgarda/E-6271-2012; Oresic, Matej/K-7673-2016; Hyötyläinen,
   Tuulia/AAP-6266-2020; Vetrani, Claudia/D-3306-2018
OI Hyotylainen, Tuulia/0000-0002-1389-8302; Patti,
   Lidia/0000-0002-0674-4188; Aura, Anna-Marja/0000-0002-8926-4744;
   Bozzetto, Lutgarda/0000-0001-6549-4476; Vetrani,
   Claudia/0000-0001-8335-5939; Oresic, Matej/0000-0002-2856-9165
FU EU [FP7-KBBE-222639]
FX This work was supported by the EU-funded project ETHERPATHS
   (FP7-KBBE-222639, http://www.etherpaths.org/). I. B-P. is grateful to
   the Carlos III Health Institute of the Spanish Ministry of Health for
   her Sara Borrell postdoctoral contract. Dr. G. Peddinti is acknowledged
   for his guidance and assistance in bioinformatics analyses.
CR Annuzzi G, 2014, AM J CLIN NUTR, V99, P463, DOI 10.3945/ajcn.113.073445
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NR 33
TC 27
Z9 28
U1 0
U2 24
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1613-4125
EI 1613-4133
J9 MOL NUTR FOOD RES
JI Mol. Nutr. Food Res.
PD SEP
PY 2014
VL 58
IS 9
BP 1873
EP 1882
DI 10.1002/mnfr.201400155
PG 10
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA AP2EQ
UT WOS:000341885700011
PM 24961394
DA 2025-06-11
ER

PT J
AU Berg, G
   Miksztowicz, V
   Schreier, L
AF Berg, Gabriela
   Miksztowicz, Veronica
   Schreier, Laura
TI Metalloproteinases in metabolic syndrome
SO CLINICA CHIMICA ACTA
LA English
DT Review
DE Metabolic syndrome; Metalloproteinases; Abdominal obesity;
   Atherosclerosis
ID LOW-DENSITY-LIPOPROTEIN; C-REACTIVE PROTEIN; FAMILIAL COMBINED
   HYPERLIPIDEMIA; INCREASED CIRCULATING LEVELS; MATRIX METALLOPROTEINASES;
   ADIPOSE-TISSUE; INCREASED EXPRESSION; CORONARY ATHEROSCLEROSIS; CELL
   PROLIFERATION; OXIDATIVE STRESS
AB Experimental and clinical evidence supports the concept that metalloproteinases (MMPs), beyond different physiologic functions, also play a role in the development and rupture of the atherosclerotic plaque. Interest in MMPs has been rapidly increasing during the last years, especially as they have been proposed as biomarkers of vulnerable plaques. Different components of the metabolic syndrome (MS) have been identified as possible stimulus for the synthesis and activity of MMPs, like pro-inflammatory and pro-oxidant state, hyperglycemia, hypertension and dyslipidemia. On the other hand, anti-inflammatory cytokines like adiponectin are inversely associated with MMPs. Among the several MMPs studied, collagenases (MMP-1 and MMP-8) and gelatinases (MMP-2 and MMP-9) are the most associated with MS. Our aim was to summarize and discuss the relation between different components of the MS on MMPs, as well as the effect of the cluster of the metabolic alterations itself. It also highlights the necessity of further studies, in both animals and humans, to elucidate the function of novel MMPs identified, as well as the role of the known enzymes in different steps of metabolic diseases. Understanding the mechanisms of MS impact on MMPs and vice versa is an interesting area of research that will positively enhance our understanding of the complexity of MS and atherosclerosis. (C) 2011 Elsevier B.V. All rights reserved.
C1 [Berg, Gabriela; Miksztowicz, Veronica; Schreier, Laura] Univ Buenos Aires, Dept Clin Biochem, Lipids & Lipoprot Lab, Fac Pharm & Biochem,INFIBIOC, RA-1053 Buenos Aires, DF, Argentina.
C3 University of Buenos Aires
RP Berg, G (corresponding author), Junin 956,CABA 1113, Buenos Aires, DF, Argentina.
EM gaberg@ffyb.uba.ar
OI Berg, Gabriela/0000-0002-5787-8960
FU University of Buenos Aires, (Argentina) [UBACYT 01/2103, B-070]
FX This work was supported by Research Grants from the University of Buenos
   Aires, (Argentina) UBACYT 01/2103 and B-070.
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NR 100
TC 47
Z9 48
U1 0
U2 9
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0009-8981
EI 1873-3492
J9 CLIN CHIM ACTA
JI Clin. Chim. Acta
PD SEP 18
PY 2011
VL 412
IS 19-20
BP 1731
EP 1739
DI 10.1016/j.cca.2011.06.013
PG 9
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA 813UU
UT WOS:000294396500005
PM 21703252
OA Green Published
DA 2025-06-11
ER

PT J
AU Freitas, RD
   Silva, CMD
   Fratelli, CF
   de Lima, LR
   Stival, MM
   Funghetto, SS
   da Silva, ICR
   de Andrade, RV
AF Freitas, Renata de Souza
   de Souza Silva, Calliandra Maria
   Ferreira Fratelli, Caroline
   Ramos de Lima, Luciano
   Morato Stival, Marina
   Schwerz Funghetto, Silvana
   Rodrigues da Silva, Izabel Cristina
   Vieira de Andrade, Rosangela
TI IL-10 and IL-1β Serum Levels, Genetic Variants, and Metabolic Syndrome:
   Insights into Older Adults' Clinical Characteristics
SO NUTRIENTS
LA English
DT Article
DE metabolic syndrome; interlekine-10; interlekine-1 beta; older
   population; IL10 rs1800890; IL1B rs1143627
ID INTERLEUKIN-10; INFLAMMATION; ASSOCIATION; ADIPONECTIN; COMPONENTS;
   CYTOKINES; OBESITY; STRESS; SYSTEM; RISK
AB Populational aging is marked by chronic noncommunicable diseases, such as metabolic syndrome (MetS). IL-10 and IL-1 beta are pleiotropic cytokines with multiple biological effects linked to metabolic disorders. This cross-sectional study assessed 193 participants' IL-10 and IL-1 beta serum levels regarding their role in developing MetS, clinical characteristics, and their IL1B rs1143627 and IL10 rs1800890 variants' genotype frequencies in a population over 60. IL-10 levels correlated weakly with HDL levels and fat mass and inversely with triglycerides, glucose, glycated hemoglobin, and estimated average blood glucose levels. IL-10 levels were also indirectly influenced by the patient's T2DM duration, lean mass amount, and bone mineral content. Participants with altered HDL, elevated serum glucose, raised HbA1c levels, or those over 80 had reduced serum IL-10 levels compared to those with normal levels or other age groups, respectively. Women also had higher serum IL-10 levels than men. Dissimilarly, IL-1 beta levels correlated directly only with the number of total leukocytes and segmented neutrophils, showing only significant variations with self-reported alcohol consumption. Our study also found that those with the IL10 AA genotype (lower IL-10 levels) had a significantly higher risk of developing MetS. These findings may help direct future research and more targeted therapeutic approaches in older adults.
C1 [Freitas, Renata de Souza; Vieira de Andrade, Rosangela] Catholic Univ Brasilia UCB, Grad Program Genom Sci & Biotechnol, BR-72220900 Brasilia, DF, Brazil.
   [de Souza Silva, Calliandra Maria; Ferreira Fratelli, Caroline; Morato Stival, Marina; Schwerz Funghetto, Silvana; Rodrigues da Silva, Izabel Cristina] Univ Brasilia, Fac Ceilandia, Grad Program Hlth Sci & Technol, BR-72220900 Brasilia, DF, Brazil.
   [de Souza Silva, Calliandra Maria; Ramos de Lima, Luciano; Morato Stival, Marina; Schwerz Funghetto, Silvana; Rodrigues da Silva, Izabel Cristina] Univ Brasilia, Fac Ceilandia, BR-72220900 Brasilia, DF, Brazil.
C3 Universidade de Brasilia; Universidade de Brasilia
RP da Silva, ICR (corresponding author), Univ Brasilia, Fac Ceilandia, Grad Program Hlth Sci & Technol, BR-72220900 Brasilia, DF, Brazil.; da Silva, ICR (corresponding author), Univ Brasilia, Fac Ceilandia, BR-72220900 Brasilia, DF, Brazil.
EM belbiomedica@gmail.com; rosangelav@p.ucb.br
RI RODRIGUES DA SILVA, IZABEL CRISTINA/HLV-7294-2023; de Lima,
   Luiz/A-4927-2015
OI FREITAS, RENATA DE SOUZA/0000-0003-3563-6415
FU Coordenao de Aperfeioamento de Pessoal de Nvel Superior-Brasil (CAPES)
FX We are grateful to the patients for participating in this study.
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NR 49
TC 3
Z9 3
U1 1
U2 1
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD APR
PY 2024
VL 16
IS 8
AR 1241
DI 10.3390/nu16081241
PG 13
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA OZ9H7
UT WOS:001211211200001
PM 38674931
OA Green Submitted, gold, Green Published
DA 2025-06-11
ER

PT J
AU Choi, JR
   Kim, JY
   Park, IH
   Huh, JH
   Kim, KW
   Cha, SK
   Park, KS
   Sohn, JH
   Park, JT
   Koh, SB
AF Choi, Jung Ran
   Kim, Jang-Young
   Park, Il Hwan
   Huh, Ji Hye
   Kim, Ki Woo
   Cha, Seung-Kuy
   Park, Kyu-Sang
   Sohn, Joon Hyung
   Park, Jong Taek
   Koh, Sang Baek
TI Serum Fibroblast Growth Factor 21 and New-Onset Metabolic Syndrome:
   KoGES-ARIRANG Study
SO YONSEI MEDICAL JOURNAL
LA English
DT Article
DE Metabolic syndrome; fibroblast growth factor 21; biomarker;
   population-based prospective study
ID ENDOPLASMIC-RETICULUM STRESS; FATTY LIVER-DISEASE; PPAR-ALPHA; OBESITY;
   FIBROBLAST-GROWTH-FACTOR-21; FGF21; PREVALENCE; REGULATOR; FGF-21;
   STATES
AB Purpose: Fibroblast growth factor 21 (FGF21) is a crucial metabolic regulator, with multiple favorable effects on glucose homeostasis and lipid metabolism. Since serum FGF21 level has been implicated as a potential marker for the early identification of metabolic syndrome (MetS), we investigated the association between serum FGF21 level and the development of MetS in a population- based prospective study.
   Materials and Methods: We conducted a prospective study of 221 randomly sampled adults without MetS from a general population- based cohort study who were examined from 2005-2008 (baseline) and from 2008-2011 (follow-up). Baseline serum FGF21 levels were analyzed using enzyme-linked immunosorbent assay.
   Results: During the average 2.8-year follow-up period, 82 participants (36.6%) developed new-onset MetS. Serum FGF21 levels were significantly higher in patients with new-onset MetS than in those without MetS (209.56 +/- 226.80 vs. 110.09 +/- 81.10, p<0.01). In multivariate adjusted models, the odds for MetS development were greater in patients with serum FGF21 levels in the highest quartile, compared to those in the lowest quartile (3.84, 95% confidence interval: 1.59-9.28).
   Conclusion: Serum FGF21 level was an independent predictor for new-onset MetS in a population-based prospective study.
C1 [Choi, Jung Ran; Kim, Jang-Young; Koh, Sang Baek] Yonsei Univ, Wonju Coll Med, Inst Genom Cohort, Wonju, South Korea.
   [Kim, Jang-Young; Huh, Ji Hye] Yonsei Univ, Wonju Coll Med, Dept Internal Med, 20 Ilsan Ro, Wonju 26426, South Korea.
   [Park, Il Hwan] Yonsei Univ, Wonju Coll Med, Dept Thorac & Cardiovasc Surg, Wonju, South Korea.
   [Kim, Ki Woo] Yonsei Univ, Wonju Coll Med, Dept Pharmacol, Wonju, South Korea.
   [Cha, Seung-Kuy; Park, Kyu-Sang; Sohn, Joon Hyung] Yonsei Univ, Wonju Coll Med, Mitohormesis Res Ctr, Wonju, South Korea.
   [Cha, Seung-Kuy; Park, Kyu-Sang] Yonsei Univ, Wonju Coll Med, Dept Physiol, Wonju, South Korea.
   [Park, Jong Taek] Yonsei Univ, Wonju Coll Med, Dept Anesthesiol & Pain Med, 20 Ilsan Ro, Wonju 26426, South Korea.
   [Koh, Sang Baek] Yonsei Univ, Wonju Coll Med, Dept Prevent Med, Wonju, South Korea.
C3 Yonsei University; Yonsei University; Yonsei University; Yonsei
   University; Yonsei University; Yonsei University; Yonsei University;
   Yonsei University
RP Kim, JY (corresponding author), Yonsei Univ, Wonju Coll Med, Dept Internal Med, 20 Ilsan Ro, Wonju 26426, South Korea.; Park, JT (corresponding author), Yonsei Univ, Wonju Coll Med, Dept Anesthesiol & Pain Med, 20 Ilsan Ro, Wonju 26426, South Korea.
EM kimjang713@gmail.com; jtp999@yonsei.ac.kr
RI park, jun yeon/GPX-5293-2022; Cha, Seung-Kuy/ABA-9147-2022; Kim, Ki
   Woo/AAW-9645-2021; Kim, Nam Hoon/HNS-5794-2023
OI Kim, Jang Young/0000-0002-0813-7082; Kim, Ki Woo/0000-0002-7790-1515;
   Park, Kyu-Sang/0000-0003-0322-9807
FU Korea Centers for Disease Control and Prevention [2005-E71013-00,
   2006-E71002-00, 2007-E71013-00, 2008-E71004-00, 2009-E71006-00,
   2010-E71003-00]; Basic Science Research Program through the National
   Research Foundation of Korea (NRF) - Ministry of Education
   [2017R1D-1A3B03034119]; Medical Research Center Program
   [2017R1A5A2015369]
FX This study was supported in part by grants from the Korea Centers for
   Disease Control and Prevention (2005-E71013-00, 2006-E71002-00,
   2007-E71013-00, 2008-E71004-00, 2009-E71006-00, and 2010-E71003-00).This
   research was supported by the Basic Science Research Program through the
   National Research Foundation of Korea (NRF), funded by the Ministry of
   Education (2017R1D-1A3B03034119).This research was also supported by the
   Medical Research Center Program 2017R1A5A2015369.
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NR 30
TC 12
Z9 13
U1 0
U2 4
PU YONSEI UNIV COLL MEDICINE
PI SEOUL
PA 50-1 YONSEI-RO, SEODAEMUN-GU, SEOUL 120-752, SOUTH KOREA
SN 0513-5796
EI 1976-2437
J9 YONSEI MED J
JI Yonsei Med. J.
PD MAR
PY 2018
VL 59
IS 2
BP 287
EP 293
DI 10.3349/ymj.2018.59.2.287
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA FW5MQ
UT WOS:000425361900017
PM 29436198
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Lamster, IB
   Pagan, M
AF Lamster, Ira B.
   Pagan, Michael
TI Periodontal disease and the metabolic syndrome
SO INTERNATIONAL DENTAL JOURNAL
LA English
DT Review
DE Periodontitis; metabolic syndrome; dysglycemia
ID INSULIN-RESISTANCE; DIABETES-MELLITUS; SYSTEMIC MARKERS; ASSOCIATION;
   INFLAMMATION; OBESITY; POPULATION; PATHOGENESIS; BURDEN; RISK
AB The metabolic syndrome (MetS) is a spectrum of conditions that increase the risk of cardiovascular disease and diabetes mellitus. The components of MetS include dysglycemia, visceral obesity, atherogenic dyslipidemia (elevated triglycerides and low levels of high-density lipoprotein) and hypertension. An association of periodontal disease and MetS has been suggested. This association is believed to be the result of systemic oxidative stress and an exuberant inflammatory response. When examined individually, the components of the MetS that are most closely related to the risk of periodontitis are dysglycemia and obesity, with lesser contributions by atherogenic dyslipidemia and hypertension. Data suggest that the odds of periodontitis increase with the number of MetS components present in an individual. The direction of the relationship between MetS and periodontal disease cannot currently be determined because the majority of studies are cross-sectional. The association between MetS and periodontitis, however, suggests that improved understanding of this association could promote interprofessional practice. Evidence suggests that periodontal therapy can reduce the levels of inflammatory mediators in serum. If this finding is confirmed, periodontal treatment could become part of therapy for MetS. Oral health providers who identify patients at risk for MetS could refer them to a medical provider, and physicians could refer patients to dentists to ensure that patients with MetS receive a dental evaluation and any necessary treatment. These clinical activities would improve both oral and general health outcomes.
C1 [Lamster, Ira B.] Columbia Univ, Dept Hlth Policy & Management, Mailman Sch Publ Hlth, New York, NY 10027 USA.
   [Pagan, Michael] Columbia Univ, Coll Dent Med, New York, NY USA.
C3 Columbia University; Columbia University
RP Lamster, IB (corresponding author), Columbia Univ, Dept Hlth Policy & Management, Mailman Sch Publ Hlth, New York, NY 10027 USA.
EM ibl1@cumc.columbia.edu
FU Leavitt Endowment at the Columbia University College of Dental Medicine;
   Colgate Oral Pharmaceuticals
FX Michael Pagan was supported by the Leavitt Endowment at the Columbia
   University College of Dental Medicine. This research was supported, in
   part, by Colgate Oral Pharmaceuticals.
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NR 68
TC 117
Z9 129
U1 0
U2 17
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0020-6539
EI 1875-595X
J9 INT DENT J
JI Int. Dent. J.
PD APR
PY 2017
VL 67
IS 2
BP 67
EP 77
DI 10.1111/idj.12264
PG 11
WC Dentistry, Oral Surgery & Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dentistry, Oral Surgery & Medicine
GA EP5GF
UT WOS:000397406300001
PM 27861820
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Amin, F
   Gilani, AH
   Mehmood, MH
   Siddiqui, BS
   Khatoon, N
AF Amin, Faridah
   Gilani, Anwarul-Hassan
   Mehmood, Malik Hassan
   Siddiqui, Bina S.
   Khatoon, Nasima
TI Coadministration of Black Seeds and Turmeric Shows Enhanced Efficacy in
   Preventing Metabolic Syndrome in Fructose-fed Rats
SO JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
LA English
DT Article
DE metabolic syndrome; fructose-fed rats; turmeric and black seeds
ID NIGELLA-SATIVA; INSULIN SENSITIVITY; WISTAR RATS; CURCUMIN; GLUCOSE;
   MODEL; INFLAMMATION; RELAXATION; STRESS; DAMAGE
AB Among noncommunicable diseases, metabolic syndrome (MS), a cluster of metabolic disorders including obesity, hyperglycemia, hyperlipidemia and hypertension, is highly prevalent in modern society. Its management requires lifestyle modifications and/or the life-long use of multiple medications, hence demanding development of safe alternative remedies. This study was aimed to establish the efficacy of combined use of black seeds and turmeric using fructose-fed rat model of MS. The high-performance liquid chromatographic fingerprints of turmeric and black seeds showed the presence of curcumin and thymoquinone, respectively, as their major constitutes. Different doses of black seeds and turmeric, individually and in combination, were administered to fructose-fed rats for up to 6 weeks representing characteristic features of MS. At 3 weeks of the treatment, black seeds and turmeric lowered (P < 0.01) high blood pressure and low-density lipoprotein cholesterol, respectively, whereas their coadministration reduced (P < 0.01) both high blood pressure and hypertriglyceridemia. At 6 weeks, the coadministration of both herbs, at half the doses of individual herbs, was the most effective (P < 0.001) in preventing hypertension, hyperglycemia, dyslipidemia, hyperinsulinemia, and endothelial dysfunction than the individual herbs. This study demonstrates the therapeutic superiority of the combination of black seeds and turmeric at low doses over individually tested herbs, in improving features of MS.
C1 [Amin, Faridah; Gilani, Anwarul-Hassan; Mehmood, Malik Hassan] Aga Khan Univ, Coll Med, Dept Biol & Biomed Sci, Karachi 74800, Pakistan.
   [Siddiqui, Bina S.; Khatoon, Nasima] Univ Karachi, HEJ Res Inst Chem, Int Ctr Chem & Biol Sci, Karachi 32, Pakistan.
   [Gilani, Anwarul-Hassan] Mekelle Univ, Coll Hlth Sci, Mekelle, Ethiopia.
C3 Aga Khan University; University of Karachi; Mekelle University
RP Gilani, AH (corresponding author), Aga Khan Univ, Coll Med, Dept Biol & Biomed Sci, Karachi 74800, Pakistan.
EM anwar.gilani@aku.edu
RI Mehmood, Dr Malik Hassan/KCJ-4885-2024; Siddiqui, bina/F-2475-2015;
   Gilani, Anwar/E-9163-2015
OI Mehmood, Malik Hassan/0000-0002-9959-1458; Siddiqui,
   Bina/0000-0001-8160-0021; Gilani, Anwar/0000-0001-6477-2227
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NR 49
TC 13
Z9 13
U1 0
U2 8
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0160-2446
EI 1533-4023
J9 J CARDIOVASC PHARM
JI J. Cardiovasc. Pharmacol.
PD FEB
PY 2015
VL 65
IS 2
BP 176
EP 183
PG 8
WC Cardiac & Cardiovascular Systems; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Pharmacology & Pharmacy
GA CB0KE
UT WOS:000349313800012
PM 25384193
DA 2025-06-11
ER

PT J
AU Sundaresan, A
   Harini, R
   Pugalendi, KV
AF Sundaresan, Arjunan
   Harini, Ranganathan
   Pugalendi, Kodukkur Viswanathan
TI Ursolic acid and rosiglitazone combination alleviates metabolic syndrome
   in high fat diet fed C57BL/6J mice
SO GENERAL PHYSIOLOGY AND BIOPHYSICS
LA English
DT Article
DE Metabolic Syndrome; High fat diet; Ursolic acid; Rosiglitazone; C57BL/6J
   mice
ID TYPE-2 DIABETES-MELLITUS; INSULIN-RESISTANCE; GLUCOSE-HOMEOSTASIS;
   OXIDATIVE STRESS; OLEANOLIC ACID; OBESITY; RATS; HYPERTENSION; WEIGHT;
   LIVER
AB The aim of this study was to examine the combined effect of ursolic acid (UA) and rosiglitazone (RSG) on metabolic syndrome in C57BL/6J mice. Upon feeding high fat diet (HFD) C57BL/6J mice developed obesity, insulin resistance, dyslipidemia and hypertension. The male mice were randomly divided into six groups, and fed normal diet, normal diet plus UA and RSG, HFD alone, HFD plus UA, HFD plus RSG, and HFD plus UA and RSG, respectively. HFD fed mice showed increase in body weight, elevated plasma glucose and insulin. Activities of gluconeogenic enzymes such as glucose 6-phosphatase, fructose 1,6-bisphosphatase increased while the activity of glycolytic enzyme, glucokinase, decreased in the liver along with glycogen content. Total cholesterol, triglyceride, low-density lipoprotein cholesterol and very low-density lipoprotein cholesterol and free fatty acid levels significantly increased in the plasma, whereas high-density lipoprotein cholesterol significantly decreased in high fat diet fed mice. In addition, both systolic and diastolic blood pressure was increased significantly. Combined treatment with UA and RSG improved the above parameters towards normality and pronounced more responses than UA or RSG lone treatment. The inclusion of UA in treatment with RSG may reduce the body weight gain, one of adverse side effect associated with the RSG-therapy.
C1 [Sundaresan, Arjunan; Harini, Ranganathan; Pugalendi, Kodukkur Viswanathan] Annamalai Univ, Dept Biochem & Biotechnol, Fac Sci, Annamalainagar 608002, Tamil Nadu, India.
C3 Annamalai University
RP Pugalendi, KV (corresponding author), Annamalai Univ, Dept Biochem & Biotechnol, Fac Sci, Annamalainagar 608002, Tamil Nadu, India.
EM pugale@sify.com
OI Arjunan, Sundaresan/0000-0001-9633-8134
FU Indian Council of Medical Research, New Delhi
FX The financial support to Arjunan Sundaresan as Senior Research
   Fellowship from Indian Council of Medical Research, New Delhi, is
   gratefully acknowledged.
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NR 54
TC 31
Z9 34
U1 0
U2 16
PU GENERAL PHYSIOL AND BIOPHYSICS
PI BRATISLAVA
PA INST OF MOLEC PHYSIOL GENETICS SLOVAK ACAD OF SCI VLARSKA 5, 83334
   BRATISLAVA, SLOVAKIA
SN 0231-5882
EI 1338-4325
J9 GEN PHYSIOL BIOPHYS
JI Gen. Physiol. Biophys.
PD SEP
PY 2012
VL 31
IS 3
BP 323
EP 333
DI 10.4149/gpb_2012_037
PG 11
WC Biochemistry & Molecular Biology; Biophysics; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Physiology
GA 010KP
UT WOS:000309093600010
PM 23047945
OA Bronze
DA 2025-06-11
ER

PT J
AU Naimipoor, N
   Bagheri-Hosseinabadi, Z
   Hajizadeh, MR
   Abbasifard, M
   Mirzaei, MR
   Anari, AG
   Mohammad-Sadeghipour, M
   Mahmoodi, M
AF Naimipoor, Neda
   Bagheri-Hosseinabadi, Zahra
   Hajizadeh, Mohammad Reza
   Abbasifard, Mitra
   Mirzaei, Mohammad Reza
   Anari, Akram Ghadiri
   Mohammad-Sadeghipour, Maryam
   Mahmoodi, Mehdi
TI Promising effects of Persian shallot extract on the serum markers and
   blood pressure of patients with metabolic syndrome: a double-blinded
   randomized controlled trial
SO JOURNAL OF TRADITIONAL CHINESE MEDICINE
LA English
DT Article
DE shallots; medicine; Persian; metabolic syndrome; antioxidants
ID OXIDATIVE STRESS; ALLICIN; DISEASE; OXIDANT
AB OBJECTIVE: To evaluate the effect of Persian shallot extract on the serum markers and blood pressure of patients with metabolic syndrome (MetS). METHODS: Fifty patients with MetS diagnosis were randomly assigned to the intervention (Persian shallot extract) and the control (placebo) group. Both groups received treatment for three months. Before the study and at the end of the study, 5 mL peripheral blood was taken from each patient. The measured factors included total antioxidant capacity (TAC), superoxide dismutase enzyme (SOD), malondialdehyde, oxidized low-density lipoprotein (Ox-LDL), apolipoprotein H (Apo-H), fasting blood glucose (FBS), total cholesterol, triglycerides, high-density lipoprotein (HDL), LDL, and systolic and diastolic blood pressure. RESULTS: At baseline, the evaluated parameters were not significantly different between the intervention and control groups. At the end of the study, the mean serum levels of malondialdehyde and ox-LDL were significantly lower in the intervention group. The mean FBS, cholesterol, triglycerides, and LDL were significantly lower in the intervention group. The mean TAC and HDL were significantly higher in the intervention group (P < 0.05). Moreover, the intervention group significantly reduced systolic and diastolic blood pressure. No other significant association was observed. CONCLUSION: Persian shallot extract has several beneficial effects in MetS patients, including optimizing oxidative balance, reducing blood pressure, fasting blood sugar, and blood lipid profile
C1 [Naimipoor, Neda; Bagheri-Hosseinabadi, Zahra; Hajizadeh, Mohammad Reza] Rafsanjan Univ Med Sci, Sch Med, Dept Clin Biochem, Rafsanjan 77181759, Iran.
   [Abbasifard, Mitra] Rafsanjan Univ Med Sci, Ali Ibn Abi Talib Hosp, Sch Med, Dept Internal Med, Rafsanjan 7717937555, Iran.
   [Mirzaei, Mohammad Reza] Rafsanjan Univ Med Sci, Res Inst Basic Med Sci, Mol Med Res Ctr, Rafsanjan 7718175911, Iran.
   [Anari, Akram Ghadiri] Shahid Sadoughi Univ Med Sci, Diabet Res Ctr, Yazd 8917693571, Iran.
   [Mohammad-Sadeghipour, Maryam; Mahmoodi, Mehdi] Kerman Univ Med Sci, Afzalipour Med Sch, Dept Dermatol, Kerman 7616914115, Iran.
   [Mohammad-Sadeghipour, Maryam; Mahmoodi, Mehdi] Kerman Univ Med Sci, Inst Neuropharmacol, Physiol Res Ctr, Kerman 7619813159, Iran.
C3 Shahid Sadoughi University of Medical Sciences; Kerman University of
   Medical Sciences; Kerman University of Medical Sciences
RP Mahmoodi, M (corresponding author), Kerman Univ Med Sci, Afzalipour Med Sch, Dept Dermatol, Kerman 7616914115, Iran.
EM me.mahmoodi@kmu.ac.ir
RI bagheri, zahra/O-5273-2018; Mohammad-Sadeghipour, Maryam/AAX-6052-2021;
   Abbasifard, mitra/I-1595-2017; Mirzaei, Mohammad Reza/C-8947-2017;
   Ghadiri-Anari, Akram/F-6290-2017
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   Sun WenLi Sun WenLi, 2019, Journal of Medicinal Plants Research, V13, P452
   Wang JY, 2022, OXID MED CELL LONGEV, V2022, DOI 10.1155/2022/7255413
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NR 52
TC 0
Z9 0
U1 4
U2 4
PU JOURNAL TRADITIONAL CHINESE MED
PI BEIJING
PA 16 NANXIAOJIE, DONGZHIMEN NEI, BEIJING, 100700, PEOPLES R CHINA
SN 0255-2922
EI 1577-7014
J9 J TRADIT CHIN MED
JI J. Tradit. Chin. Med.
PY 2025
VL 45
IS 1
BP 100
EP 106
DI 10.19852/j.cnki.jtcm.2025.01.008
PG 7
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA X2I9F
UT WOS:001423661500001
PM 39957163
DA 2025-06-11
ER

PT J
AU Choromanska, B
   Mysliwiec, P
   Luba, M
   Wojskowicz, P
   Mysliwiec, H
   Choromanska, K
   Zendzian-Piotrowska, M
   Dadan, J
   Zalewska, A
   Maciejczyk, M
AF Choromanska, Barbara
   Mysliwiec, Piotr
   Luba, Magdalena
   Wojskowicz, Piotr
   Mysliwiec, Hanna
   Choromanska, Katarzyna
   Zendzian-Piotrowska, Malgorzata
   Dadan, Jacek
   Zalewska, Anna
   Maciejczyk, Mateusz
TI Impact of Weight Loss on the Total Antioxidant/Oxidant Potential in
   Patients with Morbid Obesity-A Longitudinal Study
SO ANTIOXIDANTS
LA English
DT Article
DE obesity; bariatric surgery; laparoscopic sleeve gastrectomy;
   antioxidants; total antioxidant activity
ID LAPAROSCOPIC SLEEVE GASTRECTOMY; Y GASTRIC BYPASS; OXIDATIVE STRESS;
   URIC-ACID; INSULIN-RESISTANCE; CAPACITY; ASSOCIATION; RADICALS
AB The assessment of total antioxidant activity seems to have a higher diagnostic value than the evaluation of individual antioxidants separately. Therefore, this is the first study to assess the total antioxidant/oxidant status in morbidly obese patients undergoing bariatric surgery. The study involved 60 patients with Class 3 obesity (BMI > 40 kg/m(2)) divided into two equal subgroups: morbidly obese patients without and with metabolic syndrome. The analyses were performed in plasma samples collected before surgery as well as 1, 3, 6, and 12 months after a laparoscopic sleeve gastrectomy. Total antioxidant capacity (TAC), ferric-reducing antioxidant power (FRAP), DPPH (2,2 ' -diphenyl-1-picrylhydrazyl) radical assay, and total oxidant status (TOS) were significantly higher before surgery (as compared to the healthy controls, n = 60) and generally decreased after bariatric treatment. Interestingly, all assessed biomarkers correlated positively with uric acid content. However, the total antioxidant/oxidant potential did not differ between obese patients without metabolic syndrome and those with both obesity and metabolic syndrome. Only DPPH differentiated the two subgroups (p < 0.0001; AUC 0.8) with 73% sensitivity and 77% specificity. Plasma TAC correlated positively with body mass index, waist-hip ratio, serum insulin, and uric acid. Therefore, TAC seems to be the best biomarker to assess the antioxidant status of obese patients.
C1 [Choromanska, Barbara; Mysliwiec, Piotr; Luba, Magdalena; Wojskowicz, Piotr; Dadan, Jacek] Med Univ Bialystok, Dept Gen & Endocrine Surg 1, 24a M Sklodowskiej Curie St, PL-15276 Bialystok, Poland.
   [Mysliwiec, Hanna] Med Univ Bialystok, Dept Dermatol & Venereol, 14 Zurawia St, PL-15540 Bialystok, Poland.
   [Choromanska, Katarzyna] Med Univ Gdansk, Dept Oral Surg, 7 Debinki St, PL-80211 Gdansk, Poland.
   [Zendzian-Piotrowska, Malgorzata; Maciejczyk, Mateusz] Med Univ Bialystok, Dept Hyg Epidemiol & Ergon, 2c Mickiewicza St, PL-15233 Bialystok, Poland.
   [Zalewska, Anna] Med Univ Bialystok, Expt Dent Lab, 24a M Sklodowskiej Curie St, PL-15274 Bialystok, Poland.
C3 Medical University of Bialystok; Medical University of Bialystok;
   Fahrenheit Universities; Medical University Gdansk; Medical University
   of Bialystok; Medical University of Bialystok
RP Choromanska, B (corresponding author), Med Univ Bialystok, Dept Gen & Endocrine Surg 1, 24a M Sklodowskiej Curie St, PL-15276 Bialystok, Poland.; Maciejczyk, M (corresponding author), Med Univ Bialystok, Dept Hyg Epidemiol & Ergon, 2c Mickiewicza St, PL-15233 Bialystok, Poland.
EM barbara.choromanska@umb.edu.pl; piotr.mysliwiec@umb.edu.pl;
   ananau@wp.pl; pwojsk@wp.pl; hanna.mysliwiec@umb.edu.pl;
   kasia24_89@o2.pl; malgorzata.zendzian-piotrowska@umb.edu.pl;
   jacdad@poczta.onet.pl; anna.zalewska1@umb.edu.pl;
   mateusz.maciejczyk@umb.edu.pl
RI Zalewska, Anna/AAG-9484-2019; Myśliwiec, Piotr/T-4220-2018; Myśliwiec,
   Hanna/S-6326-2018; Żendzian-Piotrowska, Małgorzata/G-4481-2011;
   Maciejczyk, Mateusz/R-6568-2018; Zendzian-Piotrowska,
   Malgorzata/S-6354-2018
OI Maciejczyk, Mateusz/0000-0001-5609-3187; Dadan,
   Jacek/0000-0002-0691-9785; Zendzian-Piotrowska,
   Malgorzata/0000-0002-4350-0369
FU Medical University of Bialystok, Poland [SUB/1/DN/20/002/1209,
   SUB/1/DN/20/002/3330, SUB/1/DN/19/002/1140]
FX This work was supported by grants from the Medical University of
   Bialystok, Poland (grant numbers: SUB/1/DN/20/002/1209;
   SUB/1/DN/20/002/3330; SUB/1/DN/19/002/1140).
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NR 53
TC 23
Z9 23
U1 0
U2 2
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD MAY
PY 2020
VL 9
IS 5
AR 376
DI 10.3390/antiox9050376
PG 16
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA LW6WJ
UT WOS:000539284200019
PM 32369921
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Paczkowska-Abdulsalam, M
   Niemira, M
   Bielska, A
   Szalkowska, A
   Raczkowska, BA
   Junttila, S
   Gyenesei, A
   Adamska-Patruno, E
   Maliszewska, K
   Citko, A
   Szczerbinski, L
   Kretowski, A
AF Paczkowska-Abdulsalam, Magdalena
   Niemira, Magdalena
   Bielska, Agnieszka
   Szalkowska, Anna
   Raczkowska, Beata Anna
   Junttila, Sini
   Gyenesei, Attila
   Adamska-Patruno, Edyta
   Maliszewska, Katarzyna
   Citko, Anna
   Szczerbinski, Lukasz
   Kretowski, Adam
TI Evaluation of Transcriptomic Regulations behind Metabolic Syndrome in
   Obese and Lean Subjects
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE transcriptomics; obesity; obesity phenotypes; metabolic syndrome;
   cardiovascular disease
ID PERIPHERAL-BLOOD TRANSCRIPTOME; INSULIN-RESISTANCE; OXIDATIVE STRESS;
   MAMMALIAN TARGET; INFLAMMATION; EXPRESSION; DISEASE; IMPACT; CELLS;
   LINKS
AB Multiple mechanisms have been suggested to confer to the pathophysiology of metabolic syndrome (MetS), however despite great interest from the scientific community, the exact contribution of each of MetS risk factors still remains unclear. The present study aimed to investigate molecular signatures in peripheral blood of individuals affected by MetS and different degrees of obesity. Metabolic health of 1204 individuals from 1000PLUS cohort was assessed, and 32 subjects were recruited to four study groups: MetS lean, MetS obese, "healthy obese", and healthy lean. Whole-blood transcriptome next generation sequencing with functional data analysis were carried out. MetS obese and MetS lean study participants showed the upregulation of genes involved in inflammation and coagulation processes: granulocyte adhesion and diapedesis (p < 0.0001, p = 0.0063), prothrombin activation pathway (p = 0.0032, p = 0.0091), coagulation system (p = 0.0010, p = 0.0155). The results for "healthy obese" indicate enrichment in molecules associated with protein synthesis (p < 0.0001), mitochondrial dysfunction (p < 0.0001), and oxidative phosphorylation (p < 0.0001). Our results suggest that MetS is related to the state of inflammation and vascular system changes independent of excess body weight. Furthermore, "healthy obese", despite not fulfilling the criteria for MetS diagnosis, seems to display an intermediate state with a lower degree of metabolic abnormalities, before they proceed to a full blown MetS.
C1 [Paczkowska-Abdulsalam, Magdalena; Niemira, Magdalena; Bielska, Agnieszka; Szalkowska, Anna; Adamska-Patruno, Edyta; Citko, Anna; Szczerbinski, Lukasz; Kretowski, Adam] Med Univ Bialystok, Clin Res Ctr, M Sklodowskiej Curie 24A, PL-15276 Bialystok, Poland.
   [Raczkowska, Beata Anna; Maliszewska, Katarzyna; Kretowski, Adam] Med Univ Bialystok, Dept Endocrinol Diabetol & Internal Med, M Sklodowskiej Curie 24A, PL-15276 Bialystok, Poland.
   [Junttila, Sini; Gyenesei, Attila] Vienna Bioctr Core Facil, Dr Bohr Gasse 3, A-1030 Vienna, Austria.
C3 Medical University of Bialystok; Medical University of Bialystok
RP Paczkowska-Abdulsalam, M (corresponding author), Med Univ Bialystok, Clin Res Ctr, M Sklodowskiej Curie 24A, PL-15276 Bialystok, Poland.
EM magdalena.paczkowska@umb.edu.pl; Magdalena.niemira@umb.edu.pl;
   Agnieszka.bielska@umb.edu.pl; Anna.szalkowska@umb.edu.pl;
   raczkowskabeataanna@gmail.com; simaju@utu.fi; gyenesei.attila@pte.hu;
   edyta.adamska@umb.edu.pl; maliszewska.k@gmail.com;
   Anna.citko@umb.edu.pl; Lukasz.szczerbinski@umb.edu.pl;
   adamkretowski@wp.pl
RI Paczkowska-Abdulsalam, Magdalena/ABD-1828-2020; Szczerbinski,
   Lukasz/U-9000-2018; Niemira, Magdalena/T-8076-2019; Maliszewska,
   Katarzyna/U-8153-2018; Adamska-Patruno, Edyta/L-5788-2018; Kretowski,
   Adam/U-6299-2018; Niemira, Magdalena/T-9091-2018
OI Adamska-Patruno, Edyta/0000-0002-8805-0744; Kretowski,
   Adam/0000-0002-4522-4978; Niemira, Magdalena/0000-0002-0701-4961;
   Ostrowska, Agnieszka/0000-0002-2619-4494; Szczerbinski,
   Lukasz/0000-0002-6201-0605; Zeller, Anna/0000-0002-5446-544X;
   Paczkowska-Abdulsalam, Magdalena/0000-0001-7158-6983
FU Ministry of Science and Higher Education in Poland
FX This work was supported by funds from the Ministry of Science and Higher
   Education in Poland (National Leading Research Centre).
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NR 48
TC 15
Z9 17
U1 2
U2 8
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD FEB
PY 2020
VL 21
IS 4
AR 1455
DI 10.3390/ijms21041455
PG 15
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA KY4FE
UT WOS:000522524400282
PM 32093387
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Caimi, G
   Hopps, E
   Montana, M
   Carollo, C
   Calandrino, V
   Incalcaterra, E
   Canino, B
   Lo Presti, R
AF Caimi, G.
   Hopps, E.
   Montana, M.
   Carollo, C.
   Calandrino, V.
   Incalcaterra, E.
   Canino, B.
   Lo Presti, R.
TI Nitric oxide metabolites (nitrite and nitrate) in several clinical
   condition
SO CLINICAL HEMORHEOLOGY AND MICROCIRCULATION
LA English
DT Article
DE NOx; hypertension; kidney disease; metabolic syndrome; OSAS; sistemic
   sclerosis; dialysis; AMI
ID ACUTE MYOCARDIAL-INFARCTION; OBSTRUCTIVE SLEEP-APNEA;
   CHRONIC-RENAL-FAILURE; OXIDATIVE STRESS; SYSTEMIC-SCLEROSIS;
   CARDIOGENIC-SHOCK; LEUKOCYTE ACTIVATION; SYNTHASE EXPRESSION; ADHESION
   MOLECULE-1; DIABETES-MELLITUS
AB We determined the concentration of nitric oxide metabolites (NO2-+ NO3-), expressed as NOx, in several clinical conditions. Regarding this, we have examined 25 subjects with arterial hypertension, 41 subjects with chronic kidney disease in conservative treatment, 106 subjects with metabolic syndrome subdivided according to the presence (n=43) or not (n=63) of diabetes mellitus, 48 subjects with obstructive sleep apnea syndrome (OSAS),14 women with systemic sclerosis complicated with Raynaud's phenomenon, 42 dialyzed subjects and 105 young subjects with acute myocardial infarction (AMI). In subjects with arterial hypertension, chronic kidney disease, metabolic syndrome, systemic sclerosis, as well as, in dialyzed and AMI subjects, we found at baseline a NOx increase. In dyalized subjects after a standard dialysis session, we observed a decrease in NOx. The increase in NOx in juvenile AMI was significantly influenced by cigarette smoking and less by cardiovascular risk factors and the extent of coronary lesions; at 3 and 12 months later than the initial event, we observed a decrease of NOx that remains significantly higher than the control group. In subjects with OSAS no difference in NOx was noted in comparison with normal controls, although their subdivision according to the apnea/hypopnea index operates a clear distinction regarding NOx concentration.
C1 [Caimi, G.; Hopps, E.; Montana, M.; Carollo, C.; Calandrino, V.; Incalcaterra, E.; Canino, B.; Lo Presti, R.] Univ Palermo, Dipartimento Biomed Med Interna & Specialist, I-90100 Palermo, Italy.
C3 University of Palermo
RP Caimi, G (corresponding author), Univ Palermo, Dipartimento Biomed Med Interna & Specialist, Via Vespro 129, I-90100 Palermo, Italy.
EM gregorio.caimi@unipa.it
RI Carollo, Caterina/AAT-3063-2021; Montaña, Fernanda/ADG-6031-2022; LO
   PRESTI, Rosalia/J-5394-2016
OI canino, baldassare/0000-0001-6024-331X; Caimi,
   Gregorio/0000-0001-8964-255X; LO PRESTI, Rosalia/0000-0002-7491-568X
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NR 80
TC 32
Z9 33
U1 0
U2 8
PU IOS PRESS
PI AMSTERDAM
PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS
SN 1386-0291
EI 1875-8622
J9 CLIN HEMORHEOL MICRO
JI Clin. Hemorheol. Microcirc.
PY 2014
VL 56
IS 4
BP 359
EP 369
DI 10.3233/CH-131758
PG 11
WC Hematology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Hematology; Cardiovascular System & Cardiology
GA AI0GF
UT WOS:000336523500007
PM 24004551
OA Green Published
DA 2025-06-11
ER

PT J
AU He, CR
   Gai, HC
   Zhao, W
   Zhang, HQ
   Lai, L
   Ding, CY
   Chen, L
   Ding, J
AF He, Cairong
   Gai, Hongcun
   Zhao, Wen
   Zhang, Haiqin
   Lai, Lin
   Ding, Chenyu
   Chen, Lin
   Ding, Jie
TI Advances in the Study of Etiology and Molecular Mechanisms of
   Sensorineural Hearing Loss
SO CELL BIOCHEMISTRY AND BIOPHYSICS
LA English
DT Review
DE Sensorineural hearing loss; Molecular mechanisms; Cell apoptosis;
   Mitochondrial impairment; Oxidative stress; Autophagy
ID CISPLATIN-INDUCED OTOTOXICITY; OTOFERLIN GENE OTOF; OXIDATIVE STRESS;
   INNER-EAR; APOPTOSIS; MUTATIONS; CELL; EXPRESSION; MICE; COCHLEA
AB Sensorineural hearing loss (SNHL), a multifactorial progressive disorder, results from a complex interplay of genetic and environmental factors, with its underlying mechanisms remaining unclear. Several pathological factors are believed to contribute to SNHL, including genetic factors, ion homeostasis, cell apoptosis, immune inflammatory responses, oxidative stress, hormones, metabolic syndrome, human cytomegalovirus infection, mitochondrial damage, and impaired autophagy. These factors collectively interact and play significant roles in the onset and progression of SNHL. The present review offers a comprehensive overview of the various factors that contribute to SNHL, emphasizes recent developments in understanding its etiology, and explores relevant preventive and intervention measures.
C1 [He, Cairong; Gai, Hongcun; Zhao, Wen; Zhang, Haiqin; Lai, Lin; Ding, Chenyu; Chen, Lin; Ding, Jie] Guizhou Univ, Inst Agrobioengn, Coll Life Sci, Key Lab Plant Resource Conservat & Germplasm Innov, Guiyang 550025, Guizhou, Peoples R China.
C3 Guizhou University
RP Ding, J (corresponding author), Guizhou Univ, Inst Agrobioengn, Coll Life Sci, Key Lab Plant Resource Conservat & Germplasm Innov, Guiyang 550025, Guizhou, Peoples R China.
EM jding@gzu.edu.cn
RI haiqin, zhang/JEZ-4562-2023; ding, chen/KDN-1285-2024
FU National Natural Science Foundation of China; Guizhou Province Science
   and Technology Planning Project [Qianke He Foundation-ZK [2021]]; 
   [32260163];  [81960838]
FX This research was funded by the National Natural Science Foundation of
   China (No.32260163; No.81960838); Guizhou Province Science and
   Technology Planning Project (Qianke He Foundation-ZK [2021] General
   108).
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NR 128
TC 0
Z9 0
U1 6
U2 7
PU HUMANA PRESS INC
PI TOTOWA
PA 999 RIVERVIEW DRIVE SUITE 208, TOTOWA, NJ 07512 USA
SN 1085-9195
EI 1559-0283
J9 CELL BIOCHEM BIOPHYS
JI Cell Biochem. Biophys.
PD SEP
PY 2024
VL 82
IS 3
BP 1721
EP 1734
DI 10.1007/s12013-024-01344-3
EA JUN 2024
PG 14
WC Biochemistry & Molecular Biology; Biophysics; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Cell Biology
GA H6B3R
UT WOS:001243256500001
PM 38849694
DA 2025-06-11
ER

PT J
AU Faugere, M
   Maakaron, E
   Achour, V
   Verney, P
   Andrieu-Haller, C
   Obadia, J
   Fond, G
   Lançon, C
   Korchia, T
AF Faugere, Melanie
   Maakaron, Eloise
   Achour, Vincent
   Verney, Pierre
   Andrieu-Haller, Christelle
   Obadia, Jade
   Fond, Guillaume
   Lancon, Christophe
   Korchia, Theo
TI Vitamin D, B9, and B12 Deficiencies as Key Drivers of Clinical Severity
   and Metabolic Comorbidities in Major Psychiatric Disorders
SO NUTRIENTS
LA English
DT Article
DE vitamin D deficiency; folate; vitamin B12; schizophrenia; depression;
   bipolar disorder; psychiatric symptoms; metabolic syndrome; nutritional
   psychiatry
ID BIPOLAR DISORDER; DEPRESSION; FOLATE; HOMOCYSTEINE; SCHIZOPHRENIA;
   ASSOCIATION; DISEASE; NEUROINFLAMMATION; SUPPLEMENTATION; METAANALYSIS
AB Background/Objectives: Severe mental illnesses such as schizophrenia, major depressive disorder, and bipolar disorder are often accompanied by metabolic comorbidities. While the role of vitamins in physical health is well-established, their involvement in psychiatric disorders has garnered increasing attention in recent years. Methods: We conducted a cross-sectional analysis of 1003 patients diagnosed with severe mental illnesses. Vitamin D, B9, and B12 serum levels were measured, and deficiencies were defined using established clinical cutoffs. Multivariate regression analyses were performed to identify associations between vitamin deficiencies and clinical outcomes. Results: Our findings revealed that vitamin deficiencies were prevalent across all diagnostic groups, with particularly high rates in patients with schizophrenia and major depressive disorder. Vitamin D deficiency was significantly associated with worse psychiatric outcomes, including increased depressive symptoms (adjusted OR = 1.89, p = 0.018), lower Global Assessment of Functioning scores (adjusted OR = -0.18, p < 0.001), and higher rates of metabolic syndrome (adjusted OR = 1.97, p = 0.007). Folate and B12 deficiencies were also linked to greater psychiatric symptom severity and metabolic disturbances, including increased risks of obesity and dyslipidemia. Conclusions: Our study highlights the critical role of vitamins deficiencies in both psychiatric and metabolic health of patients with severe mental illnesses. These findings underscore the importance of routine screening and correction of these deficiencies as part of comprehensive care in psychiatric populations. The integration of nutritional interventions may offer a novel and holistic approach to improving both mental and physical health outcomes.
C1 [Faugere, Melanie; Maakaron, Eloise; Achour, Vincent; Verney, Pierre; Andrieu-Haller, Christelle; Obadia, Jade; Fond, Guillaume; Lancon, Christophe; Korchia, Theo] Sainte Marguer Univ Hosp, Assistance Publ Hop Marseille, Dept Acad Psychiat, F-13009 Marseille, France.
   [Faugere, Melanie; Maakaron, Eloise; Achour, Vincent; Verney, Pierre; Andrieu-Haller, Christelle; Obadia, Jade; Fond, Guillaume; Lancon, Christophe; Korchia, Theo] Aix Marseille Univ, Assistance Publ Hop Marseille, Hlth Serv Res & Qual Life Ctr CEReSS, UR3279, F-13005 Marseille, France.
   [Faugere, Melanie; Lancon, Christophe] Ctr Rech St Mentale & Psychiat Reg PACA, Groupement Cooperat Sanit, F-13100 Aix En Provence, France.
   [Faugere, Melanie] CHU Sainte Marguer, Serv Pr Christophe Lancon, Pavillon Solaris,270 Blvd St Marguer, F-13009 Marseille, France.
C3 Aix-Marseille Universite; Assistance Publique-Hopitaux de Marseille;
   Aix-Marseille Universite; Assistance Publique-Hopitaux de Marseille
RP Faugere, M (corresponding author), Sainte Marguer Univ Hosp, Assistance Publ Hop Marseille, Dept Acad Psychiat, F-13009 Marseille, France.; Faugere, M (corresponding author), Aix Marseille Univ, Assistance Publ Hop Marseille, Hlth Serv Res & Qual Life Ctr CEReSS, UR3279, F-13005 Marseille, France.; Faugere, M (corresponding author), Ctr Rech St Mentale & Psychiat Reg PACA, Groupement Cooperat Sanit, F-13100 Aix En Provence, France.; Faugere, M (corresponding author), CHU Sainte Marguer, Serv Pr Christophe Lancon, Pavillon Solaris,270 Blvd St Marguer, F-13009 Marseille, France.
EM melanie.faugere@ap-hm.fr; eloise.maakaron@ap-hm.fr;
   vincent.achour@ap-hm.fr; pierre.verney@ap-hm.fr;
   christelle.andrieu@ap-hm.fr; jade.obadia@ap-hm.fr;
   guillaume.fond@gmail.com; christophe.lancon@ap-hm.fr;
   theo.korchia@ap-hm.fr
RI Faugere, Melanie/JCP-3459-2023
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NR 112
TC 0
Z9 0
U1 0
U2 0
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD MAR 27
PY 2025
VL 17
IS 7
AR 1167
DI 10.3390/nu17071167
PG 24
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 1HC1H
UT WOS:001464872100001
PM 40218925
DA 2025-06-11
ER

PT J
AU Ersoy, S
   Engin, VS
AF Ersoy, Suleyman
   Engin, Velittin Selcuk
TI Risk factors for polypharmacy in older adults in a primary care setting:
   a cross-sectional study
SO CLINICAL INTERVENTIONS IN AGING
LA English
DT Article
DE polypharmacy; older adult; primary care; Geriatric Depression Scale;
   metabolic syndrome; neutrophililymphocyte ratio
ID MINI-MENTAL-STATE; ANTIPSYCHOTIC POLYPHARMACY; PREVALENCE; MOBILITY;
   DISEASES; SCALE; GO
AB Purpose: Polypharmacy (PP) is a clinical challenge in older adults. Therefore, assessment of daily drug consumption (DDC) and its relationships is important. First-line health services have a crucial role in monitoring and prevenfmg PP. In this study, we aimed to assess DDC and investigate the risk factors for higher DDC among older adults in a pi-Unary care setting.
   Patients and methods: A total of 1,000 patients aged 65 years who visited Melek Ilatun Family Practice Center between December I, 2014, and August 1, 2017, were enrolled in the study. All patients were seen either at the center or in their homes, and informed consent was obtained. Comprehensive geriatric assessment was performed for each subject. Data were analyzed using SPSS software (version 17). The daily number of medicines that each patient used (DDC) regardless of whether they were prescribed was the dependent variable. Relationships between DDC and other continuous variables were examined using Pearson's correlation. For between-group comparisons of DDC, Student's i-tests were performed.
   Results: Univariate tests showed relationships between DDC and various demographic and clinical parameters. The variables that remained significant at the last step of a stepwise linear regression analysis were metabolic syndrome, chronic NM, incontinence, increased serum creatinine level, increased Geriatric Depression Scale scores, reported gastric disturbances, and neutrophil lymphocyte ratio.
   Conclusion: Along With certain chronic conditions, depressive symptoms and an inflammatory marker (neutrophillymphocyte ratio) significantly and independently related to higher DDC. Longitudinal and larger studies are ceded to further explore the multifaceted relationships of PP.
C1 [Ersoy, Suleyman] Karabuk Univ, Dept Family Med, Fac Med, Alparslan Cad Sirinevler, Karabuk, Turkey.
   [Engin, Velittin Selcuk] Minist Hlth, Melekhatun Family Practice Ctr, TR-34340 Istanbul, Turkey.
C3 Karabuk University; Ministry of Health - Turkey
RP Ersoy, S (corresponding author), Karabuk Univ, Dept Family Med, Fac Med, Alparslan Cad Sirinevler, Karabuk, Turkey.
EM suleymanersoy@gmail.com
RI Ersoy, Suleyman/ABF-9062-2021; engin, velittin selcuk/AAF-8297-2019
OI engin, velittin selcuk/0000-0002-6338-4748; Ersoy,
   Suleyman/0000-0003-0001-9329
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NR 66
TC 27
Z9 27
U1 0
U2 9
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
EI 1178-1998
J9 CLIN INTERV AGING
JI Clin. Interv. Aging
PY 2018
VL 13
BP 2003
EP 2011
DI 10.2147/CIA.S176329
PG 9
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA GX2CU
UT WOS:000447526900001
PM 30410317
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT S
AU Oxenkrug, GF
AF Oxenkrug, Gregory F.
BE Andrews, RJ
   Slikker, W
   Trembly, B
   Patterson, TA
TI Metabolic syndrome, age-associated neuroendocrine disorders, and
   dysregulation of tryptophan-kynurenine metabolism
SO NEUROPROTECTIVE AGENTS
SE Annals of the New York Academy of Sciences
LA English
DT Article; Proceedings Paper
CT 9th International Conference on Neuroprotective Agents
CY SEP 07-11, 2008
CL Marine Biol Lab, Woods Hole, MA
HO Marine Biol Lab
DE metabolic syndrome; age-associated neuroendocrine disorders; tryptophan;
   kynurenine; cytokines; inflammation
ID NECROSIS-FACTOR-ALPHA; INDOLEAMINE 2,3-DIOXYGENASE ACTIVITY; SINGLE
   NUCLEOTIDE POLYMORPHISM; MAJOR DEPRESSIVE DISORDER; CHRONIC IMMUNE
   ACTIVATION; INTERFERON-GAMMA; IFN-GAMMA; N-ACETYLSEROTONIN; TNF-ALPHA;
   CARDIOVASCULAR RISK
AB The neuroendocrine theory of aging identified a cluster of conditions (hypertension, obesity, dyslipidemia, diabetes type 2, menopause, late onset depression, vascular cognitive impairment, impairment of immune defense, and some forms of cancer, e.g., breast and prostate) as age-associated neuroendocrine disorders (AAND). Obesity, dyslipidemia, hypertension, and type 2 diabetes were later described as metabolic syndromes (MetS). Chronic inflammation is currently considered as a common feature of MetS/AAND. One of the mechanisms by which chronic inflammation might trigger and/or maintain the development of MetS/AAND is transcriptional induction of indoleamine 2,3-dioxygenase (IDO), rate-limiting enzyme of tryptophan (TRY) kynurenine (KYN) pathway, by pro-inflammatory cytokines (PIC). Activation of IDO shifts TRY metabolism from serotonin synthesis to formation of "kynurenines." Diminished serotonin production is associated with mental depression while increased formation of Icynurenines might contribute to development of MetS/AAND via their apoptotic, neurotoxic, and pro-oxidative effects, and upregulation of inducible nitric oxide synthase, phospholipase A2, arachidonic acid, prostaglandin, 5-lipoxygenase, and leukotriene cascade. The combined presence of high producers of alleles of polymorphic PIG genes (e.g., interferon-gamma and tumor necrosis factor alpha) might account for the genetic predisposition to high levels of PIC production, leading to "superinduction" of IDO. The other rate-limiting enzyme of the TRY KYN pathway, TRY 2,3-dioxygenase, is activated by substrate (TRY) and cortisol. Therefore, KYN TRY metabolism might be the meeting point for gene-environment interaction and a new target for prevention and treatment of MetS/AAND.
C1 Tufts Univ, Sch Med, Dept Psychiat, Psychiat & Inflammat Program,Tufts Med Ctr, Boston, MA 02111 USA.
C3 Tufts Medical Center; Tufts University
RP Oxenkrug, GF (corresponding author), Tufts Univ, Sch Med, Dept Psychiat, Psychiat & Inflammat Program,Tufts Med Ctr, Boston, MA 02111 USA.
EM goxenkrug@tuftsmedicalcenter.org
OI Oxenkrug, Gregory/0000-0002-7193-9117
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NR 111
TC 181
Z9 195
U1 0
U2 35
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN STREET, MALDEN 02148, MA USA
SN 0077-8923
BN 978-1-57331-777-1
J9 ANN NY ACAD SCI
JI Ann.NY Acad.Sci.
PY 2010
VL 1199
BP 1
EP 14
DI 10.1111/j.1749-6632.2009.05356.x
PG 14
WC Multidisciplinary Sciences; Neurosciences
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics; Neurosciences & Neurology
GA BRJ59
UT WOS:000282838900001
PM 20633104
DA 2025-06-11
ER

PT J
AU Najafi, N
   Mehri, S
   Rahbardar, MG
   Hosseinzadeh, H
AF Najafi, Nahid
   Mehri, Soghra
   Ghasemzadeh Rahbardar, Mahboobeh
   Hosseinzadeh, Hossein
TI Effects of alpha lipoic acid on metabolic syndrome: A comprehensive
   review
SO PHYTOTHERAPY RESEARCH
LA English
DT Review
DE alpha-lipoic acid; diabetes; dyslipidemia; hypertension; metabolic
   syndrome; obesity
ID TYPE-2 DIABETES-MELLITUS; INSULIN-AUTOIMMUNE-SYNDROME; SALT-INDUCED
   HYPERTENSION; ACTIVATED PROTEIN-KINASE; GAMMA-LINOLENIC ACID;
   ACETYL-L-CARNITINE; E-DEFICIENT MICE; OXIDATIVE STRESS; ENDOTHELIAL
   DYSFUNCTION; ANTIOXIDANT STATUS
AB Metabolic syndrome (MetS) is a multifactorial disease with medical conditions such as hypertension, diabetes, obesity, dyslipidemia, and insulin resistance. Alpha-lipoic acid (alpha-LA) possesses various pharmacological effects, including antidiabetic, antiobesity, hypotensive, and hypolipidemia actions. It exhibits reactive oxygen species scavenger properties against oxidation and age-related inflammation and refines MetS components. Also, alpha-LA activates the 5 ' adenosine monophosphate-activated protein kinase and inhibits the NF kappa b. It can decrease cholesterol biosynthesis, fatty acid beta-oxidation, and vascular stiffness. alpha-LA decreases lipogenesis, cholesterol biosynthesis, low-density lipoprotein and very low-density lipoprotein levels, and atherosclerosis. Moreover, alpha-LA increases insulin secretion, glucose transport, and insulin sensitivity. These changes occur via PI3K/Akt activation. On the other hand, alpha-LA treats central obesity by increasing adiponectin levels and mitochondrial biogenesis and can reduce food intake mainly by SIRT1 stimulation. In this review, the most relevant articles have been discussed to determine the effects of alpha-LA on different components of MetS with a special focus on different molecular mechanisms behind these effects. This review exhibits the potential properties of alpha-LA in managing MetS; however, high-quality studies are needed to confirm the clinical efficacy of alpha-LA.
C1 [Najafi, Nahid] Mashhad Univ Med Sci, Student Res Comm, Mashhad, Razavi Khorasan, Iran.
   [Najafi, Nahid; Mehri, Soghra; Ghasemzadeh Rahbardar, Mahboobeh; Hosseinzadeh, Hossein] Mashhad Univ Med Sci, Sch Pharm, Dept Pharmacodynam & Toxicol, Mashhad, Razavi Khorasan, Iran.
   [Mehri, Soghra; Hosseinzadeh, Hossein] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Pharmaceut Res Ctr, Mashhad, Razavi Khorasan, Iran.
C3 Mashhad University of Medical Sciences; Mashhad University of Medical
   Sciences; Mashhad University of Medical Sciences
RP Hosseinzadeh, H (corresponding author), Mashhad Univ Med Sci, Pharmaceut Technol Inst, Pharmaceut Res Ctr, Mashhad, Razavi Khorasan, Iran.
EM hosseinzadehh@mums.ac.ir
RI mehri, soghra/P-2939-2018; Ghasemzadeh Rahbardar, Mahboobeh/V-4452-2019;
   Hosseinzadeh, Hossein/F-3013-2010
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NR 204
TC 37
Z9 40
U1 4
U2 44
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0951-418X
EI 1099-1573
J9 PHYTOTHER RES
JI Phytother. Res.
PD JUN
PY 2022
VL 36
IS 6
BP 2300
EP 2323
DI 10.1002/ptr.7406
EA MAR 2022
PG 24
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 2E6PJ
UT WOS:000762849500001
PM 35234312
DA 2025-06-11
ER

PT J
AU Merkus, D
   Muller-Delp, J
   Heaps, CL
AF Merkus, Daphne
   Muller-Delp, Judy
   Heaps, Cristine L.
TI Coronary microvascular adaptations distal to epicardial artery stenosis
SO AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
LA English
DT Review
DE collaterals; diabetes; exercise training; metabolic syndrome
ID INTENSIVE PHYSICAL-EXERCISE; CHRONIC MYOCARDIAL-ISCHEMIA; FIBROBLAST
   GROWTH FACTOR-2; NECROSIS-FACTOR-ALPHA; BYPASS GRAFT-SURGERY; COLLATERAL
   DEVELOPMENT; SWINE MODEL; METABOLIC SYNDROME; OXIDATIVE STRESS; PORCINE
   MODEL
AB Until recently, epicardial coronary stenosis has been considered the primary outcome of coronary heart disease, and clinical interventions have been dedicated primarily to the identification and removal of flow-limiting stenoses. However, a growing body of literature indicates that both epicardial stenosis and microvascular dysfunction contribute to damaging myocardial ischemia. In this review, we discuss the coexistence of macro- and microvascular disease, and how the structure and function of the distal microcirculation is impacted by the hemodynamic consequences of an epicardial, flow-limiting stenosis. Mechanisms of endothelial dysfunction as well as alterations of smooth muscle function in the coronary microcirculation distal to stenosis are discussed. Risk factors including diabetes, metabolic syndrome, and aging exacerbate microvascular dysfunction in the myocardium distal to a stenosis, and our current understanding of the role of these factors in limiting collateralization and angiogenesis of the ischemic myocardium is presented. Importantly, exercise training has been shown to promote collateral growth and improve microvascular function distal to stenosis; thus, the current literature reporting the mechanisms that underlie the beneficial effects of exercise training in the microcirculation distal to epicardial stenosis is reviewed. We also discuss recent studies of therapeutic interventions designed to improve microvascular function and stimulate angiogenesis in clinically relevant animal models of epicardial stenosis and microvascular disease. Finally, microvascular adaptation to removal of epicardial stenosis is considered.
C1 [Merkus, Daphne] Ludwig Maximilians Univ Munchen, Walter Brendel Ctr Expt Med WBex, Inst Surg Res, Univ Clin, Munich, Germany.
   [Merkus, Daphne] Munich Heart Alliance MHA, German Ctr Cardiovasc Res DZHK, Munich, Germany.
   [Merkus, Daphne] Univ Med Ctr, Dept Cardiol, Erasmus MC, Rotterdam, Netherlands.
   [Muller-Delp, Judy] Florida State Univ, Coll Med, Dept Biomed Sci, Tallahassee, FL USA.
   [Heaps, Cristine L.] Texas A&M Univ, Coll Vet Med & Biomed Sci, Dept Physiol & Pharmacol, College Stn, TX 77843 USA.
   [Heaps, Cristine L.] Texas A&M Univ, Coll Vet Med & Biomed Sci, Michael E DeBakey Inst Comparat Cardiovasc Sci &, College Stn, TX 77843 USA.
C3 University of Munich; German Centre for Cardiovascular Research; Erasmus
   University Rotterdam; Erasmus MC; State University System of Florida;
   Florida State University; Texas A&M University System; Texas A&M
   University College Station; Texas A&M University System; Texas A&M
   University College Station
RP Heaps, CL (corresponding author), Texas A&M Univ, Coll Vet Med & Biomed Sci, Dept Physiol & Pharmacol, College Stn, TX 77843 USA.; Heaps, CL (corresponding author), Texas A&M Univ, Coll Vet Med & Biomed Sci, Michael E DeBakey Inst Comparat Cardiovasc Sci &, College Stn, TX 77843 USA.
EM cheaps@cvm.tamu.edu
RI Delp, Judy/F-4303-2016; Merkus, Daphne/AAN-4459-2020
OI Merkus, Daphne/0000-0002-4852-831X; Muller-Delp,
   Judy/0000-0001-5322-0611
FU National Heart, Lung, and Blood Institute [HL139903]; German Center for
   Cardiovascular Research (DZHK) [81Z0600207]; Dutch Cardiovascular
   Alliance (DCVA-Reconnext); National Heart Lung and Blood Institute
   [R01HL139903] Funding Source: NIH RePORTER
FX This work was funded by National Heart, Lung, and Blood Institute Grant
   HL139903 (to C. L. Heaps), German Center for Cardiovascular Research
   (DZHK) Grant 81Z0600207 (to D. Merkus), and Dutch Cardiovascular
   Alliance (DCVA-Reconnext) (to D. Merkus).
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NR 182
TC 13
Z9 14
U1 0
U2 8
PU AMER PHYSIOLOGICAL SOC
PI Rockville
PA 6120 Executive Blvd, Suite 600, Rockville, MD, UNITED STATES
SN 0363-6135
EI 1522-1539
J9 AM J PHYSIOL-HEART C
JI Am. J. Physiol.-Heart Circul. Physiol.
PD JUN
PY 2021
VL 320
IS 6
BP H2351
EP H2370
DI 10.1152/ajpheart.00992.2020
PG 20
WC Cardiac & Cardiovascular Systems; Physiology; Peripheral Vascular
   Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Physiology
GA SS2LB
UT WOS:000661571800016
PM 33961506
OA Green Published
DA 2025-06-11
ER

PT J
AU Mohanty, CS
   Kodange, C
   Bhutani, S
   Sarkar, S
   Rajput, GR
   Chaudhary, DK
AF Mohanty, C. S.
   Kodange, Chaitanya
   Bhutani, Sourabh
   Sarkar, Satyasom
   Rajput, G. R.
   Chaudhary, Durgesh Kumar
TI Comparison of Prevalence of Metabolic Syndrome in Submariners with
   Shore-based Naval Personnel
SO JOURNAL OF MARINE MEDICAL SOCIETY
LA English
DT Article
DE Metabolic syndrome; prevalence; shore-based personnel; submariners
ID PHYSICAL-ACTIVITY; MILITARY PERSONNEL; RISK-FACTORS; OBESITY
AB Introduction: Metabolic syndrome refers to a clustering of metabolic risk factors including central obesity, glucose intolerance, low high-density lipoprotein (HDL) cholesterol, high triglycerides, and hypertension. In the naval setting, some occupational characteristics of submariners such as long work hours, lack of physical activity, disturbed circadian rhythm, and stress have a negative influence on the health status of individuals. It is worth speculating that the occupational factors might also influence the development of clinical conditions related to a greater cardiovascular risk such as metabolic syndrome. Materials and Methods: A cross-sectional study was conducted over a period of 2 years. Submariners posted onboard an operational submarine for the past 1 year in the age group 18-45 years and willing to participate in the study were included in the study. Shore-based personnel in the similar age group posted in shore billet for at least 1 year were taken as control. Universal sampling technique was used for selection of subjects. A total of 250 submariners and 250 age-matched shore-based naval personnel were enrolled in the study. The study group was assessed for prevalence and risk factors of metabolic syndrome using national cholesterol education program adult treatment panel III criteria. Results: The mean age of submariners and shore-based personnel was 29.7 +/- 4.9 years and 29.3 +/- 5.3 years, respectively (P = 0.77). 20.8% of the submariners had a body mass index (BMI) more than 25 kg/m(2) compared to 16.8% in the shore-based group. BMI was higher for the submariners compared to shore-based personnel but the difference was not statistically significant (P = 0.097). The prevalence of systolic and diastolic hypertension in submariners was 16.8%-15.2% compared to 11.6% and 10.4% in shore-based group (P > 0.05). Fasting blood sugar levels >100 mg/dl was observed in 14% submariners compared to 8.4% shore-based personnel (P > 0.05). Triglyceride levels of >150 mg/dl was observed in 22.4% submariners compared to 16% shore-based personnel (P = 0.085). HDL level of <40 mg/dl was observed in 13.6% submariners compared to 8.8% in shore-based personnel (P = 0.12). The prevalence of risk factors such as alcohol consumption (34% vs. 26%) and smoking (3.6% vs. 1.1%) and low physical activity (30% vs. 21.2%) were higher in the submariners as compared to the shore-based personnel though the difference was not statistically significant. The prevalence of metabolic syndrome was 9.2% in submariners compared to 6.4% in shore-based personnel. The difference was not statistically significant (P = 0.31). The overall prevalence of metabolic syndrome among submariners was higher than shore-based personnel but it was less compared to studies conducted on the Indian general population in urban areas. Conclusion: There is a need for preventive and/ or therapeutic programs focused on cardiovascular and metabolic health for submariners.
C1 [Mohanty, C. S.; Bhutani, Sourabh] INHS Asvini, Inst Naval Med, Dept Marine Med, Mumbai, Maharashtra, India.
   [Kodange, Chaitanya] King Hamad Univ Hosp, Dept Div & Hyperbar Med, Al Sayh, Bahrain.
   [Sarkar, Satyasom; Rajput, G. R.] INHS Asvini, Dept Dermatol, Mumbai, Maharashtra, India.
   [Chaudhary, Durgesh Kumar] Army Hosp Res & Referral, Dept Internal Med, New Delhi, India.
RP Chaudhary, DK (corresponding author), Army Hosp Res & Referral, Dept Internal Med, New Delhi, India.
EM drdurgesh07@gmail.com
RI Bhutani, Sourabh/AAY-9893-2020
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NR 24
TC 0
Z9 0
U1 0
U2 2
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, Maharashtra, INDIA
SN 0975-3605
EI 2589-1235
J9 J MAR MED SOC
JI J. Mar. Med. Soc.
PD JUL-DEC
PY 2023
VL 25
IS 2
BP 175
EP 181
DI 10.4103/jmms.jmms_47_23
PG 7
WC Public, Environmental & Occupational Health
WE Emerging Sources Citation Index (ESCI)
SC Public, Environmental & Occupational Health
GA Y8FB6
UT WOS:001107551800015
OA gold
DA 2025-06-11
ER

PT J
AU Sánchez-Villegas, A
   Ruíz-Canela, M
   de la Fuente-Arrillaga, C
   Gea, A
   Shivappa, N
   Hébert, JR
   Martínez-González, MA
AF Sanchez-Villegas, Almudena
   Ruiz-Canela, Miguel
   de la Fuente-Arrillaga, Carmen
   Gea, Alfredo
   Shivappa, Nitin
   Hebert, James R.
   Martinez-Gonzalez, Miguel A.
TI Dietary inflammatory index, cardiometabolic conditions and depression in
   the Seguimiento Universidad de Navarra cohort study
SO BRITISH JOURNAL OF NUTRITION
LA English
DT Article
DE Cohort studies; Dietary patterns; Depression; Anti-inflammation;
   Diabetes
ID C-REACTIVE PROTEIN; SELF-REPORTED DIAGNOSIS; METABOLIC SYNDROME;
   ASSOCIATION; SYMPTOMS; PATTERN; INTERLEUKIN-6; RISK; METAANALYSIS;
   VALIDATION
AB Only one prospective study has analysed the relationship between the inflammatory properties of diet and risk of depression thus far. The aim of this study was to assess the association between the dietary inflammatory index (DII) and the incidence of depression. In a cohort study of 15 093 university graduates, participants completed a validated FFQ at baseline and after 10 years of follow-up. The DII was calculated based on the FFQ. Each of the twenty-eight nutrients or foods received a score based on findings from the peer-reviewed literature reporting on the relationships between diet and inflammatory biomarkers (IL-1 beta, IL-4, IL-6, IL-10, TNF-alpha and C-reactive protein). Participants were classified as having depression if they reported a new clinical diagnosis of depression by a physician, antidepressant drugs, or both. Multivariable Cox regression models were used to estimate hazard ratios (HR) of depression according to quintiles of the DII. After a median 8.5 years of follow-up, we observed 1051 incident cases of depression. The HR for participants in the highest quintile of DII (strongly pro-inflammatory) was 1.47 (95 % CI 1.17, 1.85) compared with those in the bottom quintile, with a significant dose-response relationship (P-trend=0.01). In the subgroup analyses, the association between DII and depression was stronger among participants > 55 years and among those with cardiometabolic comorbidities (HR 2.70; 95 % CI 1.22, 5.97 and HR 1.80; 95 % CI 1.27, 2.57, respectively). A pro-inflammatory diet was associated with a significantly higher risk of depression in a Mediterranean population. This association was stronger among older subjects and subjects with cardiometabolic diseases.
C1 [Sanchez-Villegas, Almudena] Univ Las Palmas Gran Canaria, Res Inst Biomed & Hlth Sci, Nutr Res Grp, Las Palmas Gran Canaria 35016, Spain.
   [Sanchez-Villegas, Almudena; Ruiz-Canela, Miguel; de la Fuente-Arrillaga, Carmen; Gea, Alfredo; Martinez-Gonzalez, Miguel A.] Inst Salud Carlos III, Ciber Fisiopatol Obesidad & Nutr CIBER OBN, Madrid 28029, Spain.
   [Ruiz-Canela, Miguel; de la Fuente-Arrillaga, Carmen; Gea, Alfredo; Martinez-Gonzalez, Miguel A.] Univ Navarra, Dept Prevent Med & Publ Hlth, Pamplona 31008, Spain.
   [Shivappa, Nitin; Hebert, James R.] Univ S Carolina, Canc Prevent & Control Program, Columbia, SC 29208 USA.
   [Shivappa, Nitin; Hebert, James R.] Univ S Carolina, Dept Epidemiol & Biostat, Arnold Sch Publ Hlth, Columbia, SC 29208 USA.
C3 Universidad de Las Palmas de Gran Canaria; CIBER - Centro de
   Investigacion Biomedica en Red; CIBEROBN; Instituto de Salud Carlos III;
   University of Navarra; University of South Carolina System; University
   of South Carolina Columbia; University of South Carolina System;
   University of South Carolina Columbia
RP Sánchez-Villegas, A (corresponding author), Univ Las Palmas Gran Canaria, Res Inst Biomed & Hlth Sci, Nutr Res Grp, Las Palmas Gran Canaria 35016, Spain.
EM almudena.sanchez@ulpgc.es
RI Abad-Gurumeta, Alfredo/M-2337-2019; Martinez-Gonzalez,
   Miguel/AAE-7669-2019; Hebert, James/IUO-5628-2023; Ruiz-Canela,
   Miguel/JYP-1794-2024; Sanchez-Villegas, Almudena/T-6733-2019; Shivappa,
   Nitin/X-2215-2018; Ruiz-Canela, Miguel/I-7738-2016
OI Sanchez Villegas, Almudena/0000-0001-7733-9238; Ruiz-Canela,
   Miguel/0000-0002-7684-2787; Gea, Alfredo/0000-0002-2229-4690
FU Spanish Government [PI10/02658, PI10/02293, PI13/00615, PI14/01798,
   RD06/0045, G03/140, 87/2010]; Navarra Regional Government [45/2011,
   27/2011]; University of Navarra; United States National Institute of
   Diabetes and Digestive and Kidney Diseases [R44DK103377]
FX The SUN Study has received funding from the Spanish Government (current
   grants PI10/02658, PI10/02293, PI13/00615, PI14/01798, RD06/0045,
   G03/140 and 87/2010), the Navarra Regional Government (45/2011, 27/2011)
   and the University of Navarra. A. G. is supported by a FPU fellowship
   from the Spanish Government. N. S. and J. R. H. were supported by grant
   number R44DK103377 from the United States National Institute of Diabetes
   and Digestive and Kidney Diseases.
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   ,, 2008, The global burden of disease: 2004 update
NR 51
TC 93
Z9 97
U1 2
U2 25
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1145
EI 1475-2662
J9 BRIT J NUTR
JI Br. J. Nutr.
PD NOV 14
PY 2015
VL 114
IS 9
BP 1471
EP 1479
DI 10.1017/S0007114515003074
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA CV8IL
UT WOS:000364526600016
PM 26344165
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Nemeckova, I
   Eissazadeh, S
   Rathouska, JU
   Silhavy, J
   Malinska, H
   Pravenec, M
   Nachtigal, P
AF Nemeckova, Ivana
   Eissazadeh, Samira
   Rathouska, Jana Urbankova
   Silhavy, Jan
   Malinska, Hana
   Pravenec, Michal
   Nachtigal, Petr
TI Transgenic human C-reactive protein affects oxidative stress but not
   inflammation biomarkers in the aorta of spontaneously hypertensive rats
SO BMC CARDIOVASCULAR DISORDERS
LA English
DT Article
DE C-reactive protein; Spontaneously hypertensive rat; Aorta; Endothelial
   dysfunction; Oxidative stress
ID ENDOTHELIAL DYSFUNCTION; SOLUBLE ENDOGLIN; ENOS EXPRESSION;
   GENE-TRANSFER; HYPERCHOLESTEROLEMIA; ADIPONECTIN
AB Background C-reactive protein (CRP) is an acute inflammatory protein detected in obese patients with metabolic syndrome. Moreover, increased CRP levels have been linked with atherosclerotic disease, congestive heart failure, and ischemic heart disease, suggesting that it is not only a biomarker but also plays an active role in the pathophysiology of cardiovascular diseases. Since endothelial dysfunction plays an essential role in various cardiovascular pathologies and is characterized by increased expression of cell adhesion molecules and inflammatory markers, we aimed to detect specific markers of endothelial dysfunction, inflammation, and oxidative stress in spontaneously hypertensive rats (SHR) expressing human CRP. This model is genetically predisposed to the development of the metabolic syndrome.Methods Transgenic SHR male rats (SHR-CRP) and non-transgenic SHR (SHR) at the age of 8 months were used. Metabolic profile (including serum and tissue triglyceride (TAG), serum insulin concentrations, insulin-stimulated incorporation of glucose, and serum non-esterified fatty acids (NEFA) levels) was measured. In addition, human serum CRP, MCP-1 (monocyte chemoattractant protein-1), and adiponectin were evaluated by means of ELISA, histological analysis was used to study morphological changes in the aorta, and western blot analysis of aortic tissue was performed to detect expression of endothelial, inflammatory, and oxidative stress markers.Results The presence of human CRP was associated with significantly decreased insulin-stimulated glycogenesis in skeletal muscle, increased muscle and hepatic accumulation of TAG and decreased plasmatic cGMP concentrations, reduced adiponectin levels, and increased monocyte chemoattractant protein-1 (MCP-1) levels in the blood, suggesting pro-inflammatory and presence of multiple features of metabolic syndrome in SHR-CRP animals. Histological analysis of aortic sections did not reveal any visible morphological changes in animals from both SHR and SHR-CRP rats. Western blot analysis of the expression of proteins related to the proper function of endothelium demonstrated significant differences in the expression of p-eNOS/eNOS in the aorta, although endoglin (ENG) protein expression remained unaffected. In addition, the presence of human CRP in SHR in this study did not affect the expression of inflammatory markers, namely p-NFkB, P-selectin, and COX2 in the aorta. On the other hand, biomarkers related to oxidative stress, such as HO-1 and SOD3, were significantly changed, indicating the induction of oxidative stress.Conclusions Our findings demonstrate that CRP alone cannot fully induce the expression of endothelial dysfunction biomarkers, suggesting other risk factors of cardiovascular disorders are necessary to be involved to induce endothelial dysfunction with CRP.
C1 [Nemeckova, Ivana; Eissazadeh, Samira; Rathouska, Jana Urbankova; Nachtigal, Petr] Charles Univ Prague, Dept Biol & Med Sci, Fac Pharm Hradec Kralove, Heyrovskeho 1203, Hradec Kralove 50003, Czech Republic.
   [Silhavy, Jan; Pravenec, Michal] Acad Sci Czech Republ, Inst Physiol, Prague, Czech Republic.
   [Malinska, Hana] Inst Clin & Expt Med, Ctr Expt Med, Prague, Czech Republic.
C3 Charles University Prague; Czech Academy of Sciences; Institute of
   Physiology of the Czech Academy of Sciences; Institute for Clinical &
   Experimental Medicine (IKEM)
RP Nachtigal, P (corresponding author), Charles Univ Prague, Dept Biol & Med Sci, Fac Pharm Hradec Kralove, Heyrovskeho 1203, Hradec Kralove 50003, Czech Republic.
EM petr.nachtigal@faf.cuni.cz
RI Silhavy, Jan/B-5292-2014; Eissazadeh, Samira/ABE-2495-2020; Nachtigal,
   Petr/S-8022-2017; Nemeckova, Ivana/T-6610-2017; Rathouska,
   Jana/Q-2796-2016
OI Rathouska, Jana/0000-0001-6363-9715; Eissazadeh,
   Samira/0000-0002-6021-6589
FU Program EXCELES
FX Not applicable.
CR Abramson JL, 2005, ATHEROSCLEROSIS, V178, P115, DOI 10.1016/j.atherosclerosis.2004.08.007
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NR 26
TC 1
Z9 1
U1 1
U2 3
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1471-2261
J9 BMC CARDIOVASC DISOR
JI BMC Cardiovasc. Disord.
PD APR 16
PY 2024
VL 24
IS 1
AR 211
DI 10.1186/s12872-024-03870-7
PG 9
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA OA4Y1
UT WOS:001204537400004
PM 38627621
OA gold
DA 2025-06-11
ER

PT J
AU Roberts, JA
   Varma, VR
   Huang, CW
   An, Y
   Oommen, A
   Tanaka, T
   Ferrucci, L
   Elango, P
   Takebayashi, T
   Harada, S
   Iida, M
   Thambisetty, M
AF Roberts, Jackson A.
   Varma, Vijay R.
   Huang, Chiung-Wei
   An, Yang
   Oommen, Anup
   Tanaka, Toshiko
   Ferrucci, Luigi
   Elango, Palchamy
   Takebayashi, Toru
   Harada, Sei
   Iida, Miho
   Thambisetty, Madhav
TI Blood Metabolite Signature of Metabolic Syndrome Implicates Alterations
   in Amino Acid Metabolism: Findings from the Baltimore Longitudinal Study
   of Aging (BLSA) and the Tsuruoka Metabolomics Cohort Study (TMCS)
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE metabolic syndrome; metabolomics; amino acids; fasting glucose;
   triglycerides; waist circumference; blood pressure
ID ELECTROPHORESIS-MASS SPECTROMETRY; ALZHEIMERS-DISEASE; OXIDATIVE STRESS;
   CARDIOVASCULAR-DISEASE; TCA CYCLE; RISK; GLUTATHIONE; POPULATION;
   MORTALITY; TRENDS
AB Rapid lifestyle and dietary changes have contributed to a rise in the global prevalence of metabolic syndrome (MetS), which presents a potential healthcare crisis, owing to its association with an increased burden of multiple cardiovascular and neurological diseases. Prior work has identified the role that genetic, lifestyle, and environmental factors can play in the prevalence of MetS. Metabolomics is an important tool to study alterations in biochemical pathways intrinsic to the pathophysiology of MetS. We undertook a metabolomic study of MetS in serum samples from two ethnically distinct, well-characterized cohorts-the Baltimore Longitudinal Study of Aging (BLSA) from the U.S. and the Tsuruoka Metabolomics Cohort Study (TMCS) from Japan. We used multivariate logistic regression to identify metabolites that were associated with MetS in both cohorts. Among the top 25 most significant (lowest p-value) metabolite associations with MetS in each cohort, we identified 18 metabolites that were shared between TMCS and BLSA, the majority of which were classified as amino acids. These associations implicate multiple biochemical pathways in MetS, including branched-chain amino acid metabolism, glutathione production, aromatic amino acid metabolism, gluconeogenesis, and the tricarboxylic acid cycle. Our results suggest that fundamental alterations in amino acid metabolism may be central features of MetS.
C1 [Roberts, Jackson A.; Varma, Vijay R.; Thambisetty, Madhav] NIA, Clin & Translat Neurosci Sect, Lab Behav Neurosci, NIH, Baltimore, MD 21224 USA.
   [Huang, Chiung-Wei; An, Yang] NIA, Brain Aging & Behav Sect, Lab Behav Neurosci, NIH, Baltimore, MD 21224 USA.
   [Oommen, Anup] Natl Univ Ireland Galway, Natl Ctr Biomed Engn Sci, Glycosci Grp, Galway H91 TK33, Ireland.
   [Tanaka, Toshiko; Ferrucci, Luigi; Elango, Palchamy] NIA, Translat Gerontol Branch, NIH, Baltimore, MD 21224 USA.
   [Takebayashi, Toru; Harada, Sei; Iida, Miho] Keio Univ, Dept Prevent Med & Publ Hlth, Tokyo 1608282, Japan.
C3 National Institutes of Health (NIH) - USA; NIH National Institute on
   Aging (NIA); National Institutes of Health (NIH) - USA; NIH National
   Institute on Aging (NIA); National Institutes of Health (NIH) - USA; NIH
   National Institute on Aging (NIA); Keio University
RP Thambisetty, M (corresponding author), NIA, Clin & Translat Neurosci Sect, Lab Behav Neurosci, NIH, Baltimore, MD 21224 USA.
EM robertsjaa@nih.gov; vijay.varma@nih.gov; chiung-wei.huang@nih.gov;
   anya@grc.nia.nih.gov; anup.mammen@gmail.com; tanakato@mail.nih.gov;
   ferruccilu@grc.nia.nih.gov; elangop@mail.nih.gov;
   ttakebayashi@a3.keio.jp; seiharada@keio.jp; mihoiida1029@gmail.com;
   thambisettym@mail.nih.gov
RI Iida, Miho/NBX-2743-2025; Tanaka, Toshiko/HKW-0340-2023; Takebayashi,
   Toru/AAB-9356-2019; Harada, Sei/ABA-5975-2020; Ferrucci,
   Luigi/AED-9724-2022
OI Iida, Miho/0000-0001-5527-7574; Tanaka, Toshiko/0000-0002-4161-3829;
   Harada, Sei/0000-0003-2666-4932; Roberts, Jackson/0000-0003-2231-2454;
   Oommen, Anup/0000-0001-7653-5106; Ferrucci, Luigi/0000-0002-6273-1613
FU Intramural Research Program of the NIH, National Institute on Aging;
   Andrew and Lillian A. Posey Foundation
FX This research was supported in part by the Intramural Research Program
   of the NIH, National Institute on Aging. The funders had no role in
   study design, data collection and analysis, decision to publish, or
   preparation of the manuscript. M.T. is grateful for funding support from
   the Andrew and Lillian A. Posey Foundation to the Clinical and
   Translational Neuroscience Section, Laboratory of Behavioral
   Neuroscience, NIA.
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NR 103
TC 25
Z9 25
U1 0
U2 9
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD FEB
PY 2020
VL 21
IS 4
AR 1249
DI 10.3390/ijms21041249
PG 20
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Biochemistry & Molecular Biology; Chemistry
GA KY4FE
UT WOS:000522524400076
PM 32070008
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Marycz, K
   Kornicka, K
   Irwin-Houston, JM
   Weiss, C
AF Marycz, Krzysztof
   Kornicka, Katarzyna
   Irwin-Houston, Jennifer M.
   Weiss, Christine
TI Combination of resveratrol and 5-azacytydine improves osteogenesis of
   metabolic syndrome mesenchymal stem cells
SO JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
LA English
DT Article
DE adipose stem cells; ageing; autophagy; metabolic syndrome; mitochondria;
   osteogenic differentiation
ID OXIDATIVE STRESS; ADIPOSE-TISSUE; INSULIN-RESISTANCE; DNA METHYLATION;
   GENE-EXPRESSION; NADPH OXIDASE; DIFFERENTIATION; OBESITY; INFLAMMATION;
   DYSFUNCTION
AB Endocrine disorders have become more and more frequently diagnosed in humans and animals. In horses, equine metabolic syndrome (EMS) is characterized by insulin resistance, hyperleptinemia, hyperinsulinemia, inflammation and usually by pathological obesity. Due to an increased inflammatory response in the adipose tissue, cytophysiological properties of adipose derived stem cells (ASC) have been impaired, which strongly limits their therapeutic potential. Excessive accumulation of reactive oxygen species, mitochondria deterioration and accelerated ageing of those cells affect their multipotency and restrict the effectiveness of the differentiation process. In the present study, we have treated ASC isolated from EMS individuals with a combination of 5-azacytydine (AZA) and resveratrol (RES) in order to reverse their aged phenotype and enhance osteogenic differentiation. Using SEM and confocal microscope, cell morphology, matrix mineralization and mitochondrial dynamics were assessed. Furthermore, we investigated the expression of osteogenic-related genes with RT-PCR. We also investigated the role of autophagy during differentiation and silenced PARKIN expression with siRNA. Obtained results indicated that AZA/RES significantly enhanced early osteogenesis of ASC derived from EMS animals. Increased matrix mineralization, RUNX-2, collagen type I and osteopontin levels were noted. Furthermore, we proved that AZA/RES exerts its beneficial effects by modulating autophagy and mitochondrial dynamics through PARKIN and RUNX-2 activity.
C1 [Marycz, Krzysztof; Kornicka, Katarzyna] Wroclaw Univ Environm & Life Sci, Dept Expt Biol, Wroclaw, Poland.
   [Marycz, Krzysztof] Wroclaw Res Ctr EIT, Wroclaw, Poland.
   [Irwin-Houston, Jennifer M.; Weiss, Christine] PferdePraxis Dr Med Vet Daniel Weiss, Freienbach, Switzerland.
C3 Wroclaw University of Environmental & Life Sciences
RP Marycz, K (corresponding author), Wroclaw Univ Environm & Life Sci, Dept Expt Biol, Wroclaw, Poland.; Marycz, K (corresponding author), Wroclaw Res Ctr EIT, Wroclaw, Poland.
EM krzysztofmarycz@interia.pl
FU Narodowe Centrum Nauki [2016/21/B/NZ7/01111]
FX Narodowe Centrum Nauki, Grant/Award Number: 2016/21/B/NZ7/01111
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NR 53
TC 21
Z9 23
U1 0
U2 10
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
EI 1582-4934
J9 J CELL MOL MED
JI J. Cell. Mol. Med.
PD OCT
PY 2018
VL 22
IS 10
BP 4771
EP 4793
DI 10.1111/jcmm.13731
PG 23
WC Cell Biology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Research & Experimental Medicine
GA GU8TX
UT WOS:000445616300020
PM 29999247
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Maksyutynska, K
   Stogios, N
   Prasad, F
   Gill, J
   Hamza, Z
   De, R
   Smith, E
   Horta, A
   Goldstein, BI
   Korczak, D
   Graff-Guerrero, A
   Hahn, MK
   Agarwal, SM
AF Maksyutynska, Kateryna
   Stogios, Nicolette
   Prasad, Femin
   Gill, Jashan
   Hamza, Zaineb
   De, Riddhita
   Smith, Emily
   Horta, Angelina
   Goldstein, Benjamin I.
   Korczak, Daphne
   Graff-Guerrero, Ariel
   Hahn, Margaret K.
   Agarwal, Sri Mahavir
TI Neurocognitive correlates of metabolic dysregulation in individuals with
   mood disorders: a systematic review and meta-analysis
SO PSYCHOLOGICAL MEDICINE
LA English
DT Review; Early Access
DE attention; bipolar disorder; cognition; diabetes; executive function;
   insulin resistance; major depressive disorder; memory; metabolic
   syndrome; mood disorders; obesity; processing speed
ID MAJOR DEPRESSIVE DISORDER; LATE-LIFE DEPRESSION; BIPOLAR I DISORDER;
   BODY-MASS INDEX; COGNITIVE IMPAIRMENT; DIABETES-MELLITUS; CLINICAL
   CHARACTERISTICS; INSULIN-RESISTANCE; EXECUTIVE FUNCTION; OLDER-ADULTS
AB Individuals with mood disorders are predisposed to metabolic dysfunction, while those with metabolic dysregulation such as diabetes and obesity experience more severe depressive symptoms. Both metabolic dysfunction and mood disorders are independently associated with cognitive deficits. Therefore, given their close association, this study aimed to explore the association between metabolic dysfunction in individuals with mood disorders in relation to cognitive outcomes. A comprehensive search comprised of these three domains was carried out; a random-effects meta-analysis pooling mean cognitive outcomes was conducted (PROSPERO ID: CRD42022295765). Sixty-three studies were included in this review; 26 were synthesized in a quantitative meta-analysis. Comorbid metabolic dysregulation was associated with significantly lower global cognition among individuals with mood disorders. These trends were significant within each mood disorder subgroup, including major depressive disorder, bipolar disorder, and self-report depression/depressive symptoms. Type 2 diabetes was associated with the lowest cognitive performance in individuals with mood disorders, followed by peripheral insulin resistance, body mass index >= 25 kg/m(2), and metabolic syndrome. Significant reduction in scores was also observed among individual cognitive domains (in descending order) of working memory, attention, executive function, processing speed, verbal memory, and visual memory. These findings demonstrate the detrimental effects of comorbid metabolic dysfunction in individuals with mood disorders. Further research is required to understand the underlying mechanisms connecting mood disorders, metabolism, and cognition.
C1 [Maksyutynska, Kateryna; Stogios, Nicolette; Prasad, Femin; Gill, Jashan; Hamza, Zaineb; De, Riddhita; Smith, Emily; Horta, Angelina; Goldstein, Benjamin I.; Korczak, Daphne; Graff-Guerrero, Ariel; Hahn, Margaret K.; Agarwal, Sri Mahavir] Univ Toronto, Inst Med Sci, Toronto, ON, Canada.
   [Maksyutynska, Kateryna; Stogios, Nicolette; Prasad, Femin; De, Riddhita; Smith, Emily; Hahn, Margaret K.; Agarwal, Sri Mahavir] Ctr Addict & Mental Hlth, Schizophrenia Div, Toronto, ON, Canada.
   [Gill, Jashan] McMaster Univ, Fac Sci, Hamilton, ON, Canada.
   [Hamza, Zaineb; Horta, Angelina] McMaster Univ, Fac Hlth Sci, Hamilton, ON, Canada.
   [Goldstein, Benjamin I.; Korczak, Daphne; Graff-Guerrero, Ariel; Hahn, Margaret K.; Agarwal, Sri Mahavir] Univ Toronto, Fac Med, Dept Psychiat, Toronto, ON, Canada.
   [Goldstein, Benjamin I.] Ctr Addict & Mental Hlth, Ctr Youth Bipolar Disorder, Toronto, ON, Canada.
   [Goldstein, Benjamin I.] Univ Toronto, Dept Pharmacol & Toxicol, Toronto, ON, Canada.
   [Korczak, Daphne] Hosp Sick Children, Dept Psychiat, Toronto, ON, Canada.
   [Graff-Guerrero, Ariel] Ctr Addict & Mental Hlth, Res Imaging Ctr, Toronto, ON, Canada.
C3 University of Toronto; University of Toronto; Centre for Addiction &
   Mental Health - Canada; McMaster University; McMaster University;
   University of Toronto; University of Toronto; Centre for Addiction &
   Mental Health - Canada; University of Toronto; University of Toronto;
   Hospital for Sick Children (SickKids); University of Toronto; Centre for
   Addiction & Mental Health - Canada
RP Agarwal, SM (corresponding author), Univ Toronto, Inst Med Sci, Toronto, ON, Canada.; Agarwal, SM (corresponding author), Ctr Addict & Mental Hlth, Schizophrenia Div, Toronto, ON, Canada.; Agarwal, SM (corresponding author), Univ Toronto, Fac Med, Dept Psychiat, Toronto, ON, Canada.
EM Mahavir.Agarwal@camh.ca
RI Agarwal, Mahavir/ITV-3244-2023; Goldstein, Benjamin/ADR-2374-2022
OI De, Riddhita/0000-0002-8953-4716; Stogios, Nicolette/0000-0001-9136-4923
FU Academic Scholars Award from the Department of Psychiatry, University of
   Toronto; CAMH Discovery Fund; RBC Investments Chair in Children's Mental
   Health and Developmental Psychopathology at CAMH; University of Toronto,
   CAMH; CAMH Foundation
FX The authors would like to thank Dr Van Rheenen et al., Dr Hubenak et
   al., and Dr Geraets et al. for providing additional information to
   synthesize in this review. S. M. A. is supported by in part by an
   Academic Scholars Award from the Department of Psychiatry, University of
   Toronto and the CAMH Discovery Fund. B. I. G. acknowledges his position
   as RBC Investments Chair in Children's Mental Health and Developmental
   Psychopathology at CAMH, a joint Hospital-University Chair between the
   University of Toronto, CAMH, and the CAMH Foundation.
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NR 92
TC 7
Z9 7
U1 6
U2 21
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0033-2917
EI 1469-8978
J9 PSYCHOL MED
JI Psychol. Med.
PD 2024 MAR 7
PY 2024
DI 10.1017/S0033291724000345
EA MAR 2024
PG 27
WC Psychology, Clinical; Psychiatry; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA MJ1E6
UT WOS:001193154900001
PM 38450447
OA hybrid
DA 2025-06-11
ER

PT J
AU Morán-Ramos, S
   Avila-Nava, A
   Tovar, AR
   Pedraza-Chaverri, J
   Lopez-Romero, P
   Torres, N
AF Moran-Ramos, Sofia
   Avila-Nava, Azalia
   Tovar, Armando R.
   Pedraza-Chaverri, Jose
   Lopez-Romero, Patricia
   Torres, Nimbe
TI Opuntia ficus indica (Nopal) Attenuates Hepatic Steatosis and
   Oxidative Stress in Obese Zucker (fa/fa) Rats
SO JOURNAL OF NUTRITION
LA English
DT Article
ID FATTY LIVER-DISEASE; INSULIN-RESISTANCE; METABOLIC SYNDROME; INDUCED
   NEPHROTOXICITY; ADIPONECTIN RECEPTORS; SOY PROTEIN; STEATOHEPATITIS;
   MODELS; BLOOD; FIBER
AB Nonalcoholic fatty liver disease (NAFLD) is associated with multiple factors such as obesity, insulin resistance, and oxidative stress. Nopal, a cactus plant widely consumed in the Mexican diet, is considered a functional food because of its antioxidant activity and ability to improve biomarkers of metabolic syndrome. The aim of this study was to assess the effect of nopal consumption on the development of hepatic steatosis and hepatic oxidative stress and on the regulation of genes involved in hepatic lipid metabolism. Obese Zucker (fa/fa) rats were fed a control diet or a diet containing 4% nopal for 7 wk. Rats fed the nopal-containing diet had similar to 50% lower hepatic TG than the control group as well as a reduction in hepatomegaly and biomarkers of hepatocyte injury such as alanine and aspartate aminotransferases. Attenuation of hepatic steatosis by nopal consumption was accompanied by a higher serum concentration of adiponectin and a greater abundance of mRNA for genes involved in lipid oxidation and lipid export and production of carnitine palmitoyltransferase-1 and microsomal TG transfer proteins in liver. Hepatic reactive oxygen species and lipid peroxidation biomarkers were significantly lower in rats fed nopal compared with the control rats. Furthermore, rats fed the nopal diet had a lower postprandial serum insulin concentration and a greater liver phosphorylated protein kinase B (pAKT):AKT ratio in the postprandial state. This study suggests that nopal consumption attenuates hepatic steatosis by increasing fatty acid oxidation and VLDL synthesis, decreasing oxidative stress, and improving liver insulin signaling in obese Zucker (fa/fa) rats. J. Nutr. 142: 1956-1963, 2012.
C1 [Moran-Ramos, Sofia; Tovar, Armando R.; Lopez-Romero, Patricia; Torres, Nimbe] Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Fisiol Nutr, Mexico City, DF, Mexico.
   [Avila-Nava, Azalia; Pedraza-Chaverri, Jose] Univ Nacl Autonoma Mexico, Fac Quim, Dept Biol, Mexico City 04510, DF, Mexico.
   [Moran-Ramos, Sofia] Univ Nacl Autonoma Mexico, Fac Med, Mexico City 04510, DF, Mexico.
C3 Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran -
   Mexico; Universidad Nacional Autonoma de Mexico; Universidad Nacional
   Autonoma de Mexico
RP Torres, N (corresponding author), Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Fisiol Nutr, Mexico City, DF, Mexico.
EM nimbester@gmail.com
RI Moran, Sofia/AAK-8815-2021; Torres, Nimbe/AAI-4340-2020
OI Avila-Nava, Azalia/0000-0003-3363-1477
FU Instituto Nacional de Ciencia y Tecnologia del D.F. [PICDS08-6]; Grupo
   Produce del D.F; Programa de Apoyo a Proyectos de Investigacion e
   Innovacion Tecnologica [IN201910]; Consejo Nacional de Ciencia y
   Tecnologi (CONACYT) [129838]; CONACYT
FX Supported in part by Instituto Nacional de Ciencia y Tecnologia del D.F.
   grant PICDS08-6 (N.T.) and Grupo Produce del D.F (N.T.), Programa de
   Apoyo a Proyectos de Investigacion e Innovacion Tecnologica IN201910
   (J.P.-C.) and Consejo Nacional de Ciencia y Tecnologi (CONACYT) 129838
   (J.P.-C.). S.M.-R. and A.A.-N. received scholarships from CONACYT.
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NR 38
TC 58
Z9 62
U1 0
U2 26
PU AMER SOC NUTRITION-ASN
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-3166
J9 J NUTR
JI J. Nutr.
PD NOV
PY 2012
VL 142
IS 11
BP 1956
EP 1963
DI 10.3945/jn.112.165563
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 028IQ
UT WOS:000310416400006
PM 23014486
OA Bronze
DA 2025-06-11
ER

PT J
AU Van Gaal, L
   Pt-Sunyer, X
   Després, JP
   McCarthy, C
   Scheen, A
AF Van Gaal, Luc
   Pt-Sunyer, Xavier
   Despres, Jean-Pierre
   McCarthy, Christine
   Scheen, Andre
TI Efficacy and Safety of Rimonabant for Improvement of Multiple
   Cardiometabolic Risk Factors in Overweight/Obese patients Pooled 1-year
   data from the Rimonabant in Obesity (RIO) program
SO DIABETES CARE
LA English
DT Article; Proceedings Paper
CT 1st Meeting on Controversies in Obesity, Diabetes and Hypertension
CY OCT, 2006
CL Berlin, GERMANY
ID CANNABINOID-1 RECEPTOR BLOCKER; ENDOCANNABINOID SYSTEM; METABOLIC
   SYNDROME; GLUCOSE-TOLERANCE; WEIGHT-REDUCTION; HOSPITAL ANXIETY;
   ADIPOSE-TISSUE; DYSREGULATION; ACTIVATION; INSULIN
AB OBJECTIVE- To better define the efficacy and safety of rimonabant, the first selective cannabinoid type 1 (CB1) receptor antagonist, in a large population of overweight and obese patients using pooled efficacy data from three Phase III nondiabetes Rimonabant, in Obesity and Related Metabolic Disorders (RIO) studies, selected efficacy data from the RIO-Diabetes study, and pooled safety data for all four RIO studies.
   RESEARCH DESIGN AND METHODS - The RIO studies enrolled patients who were either overweight (BMI >27 kg/m(2)) with at least one comorbidity (i.e., hypertension, dyslipidemia, or, for RIO-Diabetes, type 2 diabetes) or obese. All patient, received daily treatment with rimonabant (5 or 20 mg) or placebo for 1 year plus a hypocaloric diet (600 kcal/day deficit) and advice on increased physical activity. RIO-Europe (n = 1,508), RIO-North America (n = 3,045), and RIO-Lipids (n = 1,036) excluded patients with type 2 diabetes; untreated dyslipidemia was art entry requirement for RIO-Lipids. RIO-Diabetes (n - 1,047) required the presence of type 2 diabetes inadequately controlled by sulfonylurea or metformin monotherapy.
   RESULTS - The pooled intention-to-treat population comprised 5,580 patients without diabetes (3,165 completed treatment) and 1,047 patients with diabetes (692 completed treatment). Most efficacy measures improved during the 4-week placebo run-in period, except that HDL cholesterol decreased as expected in the early phase of a hypocaloric diet. After 1 year of randomized treatment, changes from baseline with 20 mg rimonabant in the nondiabetic population were as follows: body weight -6.5 kg, waist circumference -6.4 cm, HDL cholesterol +16.4%, triglycerides -6.9%, fasting insulin -0.6 mu U/ml, and homeostasis model assessment for insulin resistance (HOMA-IR) -0.2 (all P < 0.001 vs. placebo). In the diabetic population, 20 mg rimonabant reduced A1C levels by 06% (P < 0.001 vs. placebo). Regression analysis of change in HDL cholesterol, triglycerides, adiponectin (in RIO-Lipids), and A1C (in RIO-Diabetes) versus body weight at 1 year by ANCOVA suggested that 45-57% of the effect of rimonabant could not be explained by the observed weight loss. At 1 year, adverse events more
C1 [Van Gaal, Luc] Univ Antwerp Hosp, Fac Med, Dept Diabet Metab & Clin Nutr, B-2650 Edegem, Belgium.
   [Pt-Sunyer, Xavier] St Lukes Roosevelt Hosp, New York, NY USA.
   [McCarthy, Christine] Sanofi Aventis, Chilly Mazarn, France.
   [Scheen, Andre] Univ Liege, CHU Sart Tilman, Div Diabet Nutr & Metab Disorders, Liege, Belgium.
   [Despres, Jean-Pierre] Univ Laval, Laval Hosp Res Ctr, Quebec Heart Inst, Ste Foy, PQ G1K 7P4, Canada.
C3 University of Antwerp; Mount Sinai St. Luke's; Mount Sinai West;
   Sanofi-Aventis; University of Liege; Laval University
RP Van Gaal, L (corresponding author), Univ Antwerp Hosp, Fac Med, Dept Diabet Metab & Clin Nutr, Wilrijkstr 10, B-2650 Edegem, Belgium.
EM luc.van.gaal@uza.be
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NR 38
TC 172
Z9 188
U1 0
U2 9
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0149-5992
EI 1935-5548
J9 DIABETES CARE
JI Diabetes Care
PD FEB
PY 2008
VL 31
SU 2
BP S229
EP S240
DI 10.2337/dc08-s258
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Endocrinology & Metabolism
GA 426IM
UT WOS:000264701200023
PM 18227491
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Li, XN
   Song, J
   Zhang, L
   LeMaire, SA
   Hou, XY
   Zhang, C
   Coselli, JS
   Chen, L
   Wang, XL
   Zhang, Y
   Shen, YH
AF Li, Xiao-Nan
   Song, Jun
   Zhang, Lin
   LeMaire, Scott A.
   Hou, Xiaoyang
   Zhang, Cheng
   Coselli, Joseph S.
   Chen, Li
   Wang, Xing Li
   Zhang, Yun
   Shen, Ying H.
TI Activation of the AMPK-FOXO3 Pathway Reduces Fatty Acid-Induced Increase
   in Intracellular Reactive Oxygen Species by Upregulating Thioredoxin
SO DIABETES
LA English
DT Article
ID PROTEIN-KINASE; OXIDATIVE-STRESS; ENDOTHELIAL-CELLS; CROSS-TALK; FOXO;
   INHIBITION; ADIPONECTIN; SUPPRESSION; RESISTANCE; EXPRESSION
AB OBJECTIVE-Oxidative stress induced by free fatty acids contributes to the development of cardiovascular diseases in patients with metabolic syndrome. Reducing oxidative stress may attenuate these pathogenic processes. Activation of AMP-activated protein kinase (AMPK) has been reported to reduce intraceRular reactive oxygen species (ROS) levels. The thioredoxin (Trx) system is a major antioxidant system. In this study, we investigated the mechanisms involved in the AMPK-mediated regulation of Trx expression and the reduction of intracellular ROS levels.
   RESEARCH DESIGN AND METHODS-We observed that activation of AMPK by 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR) significantly reduced ROS levels induced by palmitic acid in human aortic endothelial cells. Activation of AMPK increased expression of the antioxidant Trx, which mediated the ROS reduction. RT-PCR showed that AMPK regulated Trx at the transcriptional level.
   RESULTS-Forkhead transcription factor 3 (FOXO3) was identified as the target transcription factor involved in the upregulation of Trx expression. FOXO3 bound to the Trx promoter, recruited the histone acetylase p300 to the Trx promoter, and formed a transcription activator complex, which was enhanced by AICAR treatment. AMPK activated FOXO3 by promoting its nuclear translocation. We further showed that AICAR injection increased the expression of Trx and decreased ROS production in the aortic wall of ApoE-/- mice fed a high-fat diet.
   CONCLUSIONS-These results suggest that activation of the AMPK-FOXO3 pathway reduces ROS levels by inducing Trx expression. Thus, the AMPK-FOXO3-Trx axis may be an important defense mechanism against excessive ROS production induced by metabolic stress and could be a therapeutic target in treating cardiovascular diseases in metabolic syndrome. Diabetes 58:2246-2257, 2009
C1 [Li, Xiao-Nan; Song, Jun; Hou, Xiaoyang; Zhang, Cheng; Chen, Li; Zhang, Yun] Shandong Univ, Qilu Hosp, Jinan 250100, Shandong, Peoples R China.
   [Li, Xiao-Nan; Song, Jun; Zhang, Lin; LeMaire, Scott A.; Hou, Xiaoyang; Zhang, Cheng; Coselli, Joseph S.; Wang, Xing Li; Shen, Ying H.] Baylor Coll Med, Div Cardiothorac Surg, Michael E DeBakey Dept Surg, Houston, TX 77030 USA.
   [Li, Xiao-Nan; Song, Jun; Zhang, Lin; LeMaire, Scott A.; Hou, Xiaoyang; Zhang, Cheng; Coselli, Joseph S.; Wang, Xing Li; Shen, Ying H.] St Lukes Episcopal Hosp, Texas Heart Inst, Houston, TX USA.
C3 Shandong University; Baylor College of Medicine; Saint Lukes Episcopal
   Hospital; Texas Heart Institute
RP Zhang, Y (corresponding author), Shandong Univ, Qilu Hosp, Jinan 250100, Shandong, Peoples R China.
EM zhangyun@sdu.edu.cn; hyshen@bcm.edu
RI wang, xingli/MHR-1399-2025; shen, ying/HHS-5635-2022
OI LeMaire, Scott/0000-0002-8736-4266
FU American Heart Association [AHA-TX 0565134Y, AHA-073019ON]; National
   Institutes of Health [R01HL071608]; Natural Science Foundation of China
   [2006CB503803, 2006AA02A406]
FX This study was supported by American Heart Association Grants AHA-TX
   0565134Y (to Y.H.S.) and AHA-073019ON (to Y.H.S.), National Institutes
   of Health Grant R01HL071608 (to X.L.W.), and Natural Science Foundation
   of China Grants 2006CB503803 and 2006AA02A406 (to Y.Z.).
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NR 46
TC 203
Z9 234
U1 2
U2 34
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0012-1797
EI 1939-327X
J9 DIABETES
JI Diabetes
PD OCT
PY 2009
VL 58
IS 10
BP 2246
EP 2257
DI 10.2337/db08-1512
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 506LL
UT WOS:000270776200012
PM 19592618
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Dimova, EY
   Samoylenko, A
   Kietzmann, T
AF Dimova, EY
   Samoylenko, A
   Kietzmann, T
TI Oxidative stress and hypoxia: Implications for plasminogen activator
   inhibitor-1 expression
SO ANTIOXIDANTS & REDOX SIGNALING
LA English
DT Review
ID NF-KAPPA-B; SMOOTH-MUSCLE-CELLS; INDUCIBLE FACTOR-I;
   NECROSIS-FACTOR-ALPHA; SIGNAL-REGULATED KINASE; VASCULAR
   ENDOTHELIAL-CELLS; TUMOR-SUPPRESSOR PROTEIN; LDL-INDUCED GENERATION;
   DNA-BINDING ACTIVITY; GROWTH-FACTOR-BETA
AB Plasminogen activator inhibitor-1 (PAI-1) is the major physiological inhibitor of urokinase-type and tissue-type plasminogen activators. It has gained special interest among clinicians because a number of pathological conditions, such as myocardial infarction, atherosclerosis, thrombosis, several types of cancer, and the metabolic syndrome, as well as type 2 diabetes mellitus, are associated with increased PAI-1 levels. Interestingly, a number of these diseases are also accompanied by oxidative stress and the enhanced production of reactive oxygen species or tissue hypoxia. This article tries to summarize some aspects leading to enhanced PAI-1 production under oxidative stress or hypoxia.
C1 Inst Biochem & Mol Zellbiol, D-37073 Gottingen, Germany.
RP Inst Biochem & Mol Zellbiol, Humboldtallee 23, D-37073 Gottingen, Germany.
EM tkietzm@gwdg.de
RI Dimova, Emiliya/D-1110-2010; Samoylenko, Anatoliy/AAN-1992-2021
OI Dimova, Elitsa/0000-0003-2745-8145; Kietzmann,
   Thomas/0000-0003-0242-8636; Samoylenko, Anatoliy/0000-0002-0240-897X
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NR 133
TC 44
Z9 45
U1 1
U2 3
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1523-0864
EI 1557-7716
J9 ANTIOXID REDOX SIGN
JI Antioxid. Redox Signal.
PD AUG
PY 2004
VL 6
IS 4
BP 777
EP 791
DI 10.1089/1523086041361596
PG 15
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 843SI
UT WOS:000223106400012
PM 15242559
DA 2025-06-11
ER

PT J
AU Girona, J
   Rodríguez-Borjabad, C
   Ibarretxe, D
   Vallvé, JC
   Ferré, R
   Heras, M
   Rodríguez-Calvo, R
   Guaita-Esteruelas, S
   Martínez-Micaelo, N
   Plana, N
   Masana, L
AF Girona, Josefa
   Rodriguez-Borjabad, Celia
   Ibarretxe, Daiana
   Vallve, Joan-Carles
   Ferre, Raimon
   Heras, Mercedes
   Rodriguez-Calvo, Ricardo
   Guaita-Esteruelas, Sandra
   Martinez-Micaelo, Neus
   Plana, Nuria
   Masana, Lluis
TI The Circulating GRP78/BiP Is a Marker of Metabolic Diseases and
   Atherosclerosis: Bringing Endoplasmic Reticulum Stress into the Clinical
   Scenario
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Article
DE GRP78/BiP; endoplasmic reticulum stress; atherosclerosis; carotid
   intima-media thickness; obesity; type 2 diabetes; metabolic syndrome;
   cardiovascular risk; fenofibrate/niacin treatment
ID ER STRESS; ADIPOSE-TISSUE; INSULIN; OBESE; CHOLESTEROL; FENOFIBRATE;
   HOMEOSTASIS; RESISTANCE; INDUCTION; MECHANISM
AB Background: Glucose-regulated protein 78/Binding immunoglobulin protein (GRP78/BiP) is a protein associated with endoplasmic reticulum stress and is upregulated by metabolic alterations at the tissue-level, such as hypoxia or glucose deprivation, and it is hyper-expressed in fat tissue of obese individuals. Objective: To investigate the role of the GRP78/BiP level as a metabolic and vascular disease biomarker in patients with type 2 diabetes (DM), obesity and metabolic syndrome (MS). Methods: Four hundred and five patients were recruited, of whom 52.5% were obese, 72.8% had DM, and 78.6% had MS. The intimae media thickness (cIMT) was assessed by ultrasonography. The plasma GRP78/BiP concentration was determined, and its association with metabolic and vascular parameters was assessed. Circulating GRP78/BiP was also prospectively measured in 30 DM patients before and after fenofibrate/niacin treatment and 30 healthy controls. Results: In the cross-sectional study, the GRP78/BiP level was significantly higher in the patients with obesity, DM, and MS. Age-, gender- and BMI-adjusted GRP78/BiP was directly associated with LDL-cholesterol, non-HDL-cholesterol, triglycerides, apoB, and cIMT. GRP78/BiP was positively associated to carotid plaque presence in the adjusted model, irrespective of obesity, DM and MS. In the prospective study, nicotinic acid treatment produced a significant reduction in the GRP78/BiP levels that was not observed with fenofibrate. Conclusions: GRP78/BiP plasma concentrations are increased in patients with both metabolic derangements and subclinical atherosclerosis. GRP78/BiP could be a useful marker of metabolic and cardiovascular risk.
C1 [Girona, Josefa; Rodriguez-Borjabad, Celia; Ibarretxe, Daiana; Vallve, Joan-Carles; Ferre, Raimon; Heras, Mercedes; Rodriguez-Calvo, Ricardo; Guaita-Esteruelas, Sandra; Martinez-Micaelo, Neus; Plana, Nuria; Masana, Lluis] Univ Rovira & Virgili, St Joan Univ Hosp, Vasc Med & Metab Unit, IISPV,Res Unit Lipids & Atherosclerosis, Reus 43201, Spain.
   [Girona, Josefa; Rodriguez-Borjabad, Celia; Ibarretxe, Daiana; Vallve, Joan-Carles; Ferre, Raimon; Heras, Mercedes; Rodriguez-Calvo, Ricardo; Martinez-Micaelo, Neus; Plana, Nuria; Masana, Lluis] Spanish Biomed Res Ctr Diabet & Associated Metab, Madrid 28029, Spain.
C3 Universitat Rovira i Virgili; Institut d'Investigacio Sanitaria Pere
   Virgili (IISPV)
RP Masana, L (corresponding author), Univ Rovira & Virgili, St Joan Univ Hosp, Vasc Med & Metab Unit, IISPV,Res Unit Lipids & Atherosclerosis, Reus 43201, Spain.; Masana, L (corresponding author), Spanish Biomed Res Ctr Diabet & Associated Metab, Madrid 28029, Spain.
EM josefa.girona@urv.cat; celia.nutricio@gmail.com;
   daiana.ibarretxe@urv.cat; jc.vallve@urv.cat; rferre@grupsagessa.cat;
   mercedes.heras@urv.cat; ricardo.rodriguez@ciberdem.com;
   sandra.guaita@urv.cat; neus.martinez@urv.cat; nplana@grupsagessa.cat;
   luis.masana@urv.cat
RI Rodriguez-Calvo, Ricardo/AAB-4054-2019; Vallvé, Joan-Carles/T-6742-2019;
   MASANA, LUIS/M-7002-2019; Girona, Josefa/U-3489-2018
OI Girona, Josefa/0000-0002-6267-8779; Vallve,
   Joan-Carles/0000-0001-8711-9618; Rodriguez-Borjabad,
   Celia/0000-0001-8160-3716; Plana, Nuria/0000-0002-4231-7618;
   Martinez-Micaelo, Neus/0000-0001-6101-2847; Masana,
   Luis/0000-0002-0789-4954; Ibarretxe, Daiana/0000-0002-5442-1930
FU Instituto de Salud Carlos III (ISCIII), Madrid, Spain [PI15/00627,
   PI18/00515]; Spanish Biomedical Research Centre in Diabetes and
   Associated Metabolic Disorders (CIBERDEM) - European Regional
   Development Fund (ERDF)
FX This study was funded by grants from Instituto de Salud Carlos III
   (ISCIII), Madrid, Spain (PI15/00627; PI18/00515). This work was jointly
   supported by national funding from the Spanish Biomedical Research
   Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM). This
   work was co-funded by the European Regional Development Fund (ERDF).
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NR 33
TC 52
Z9 53
U1 0
U2 8
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD NOV
PY 2019
VL 8
IS 11
AR 1793
DI 10.3390/jcm8111793
PG 11
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA JV3VR
UT WOS:000502294400036
PM 31717752
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Mihai, A
   Lixandru, D
   Alexandru, P
   Stoian, I
   Carniciu, S
   Mitu, M
   Guja, C
   Ionescu-Tirgoviste, C
AF Mihai, Andrada
   Lixandru, Daniela
   Alexandru, Petruta
   Stoian, Irina
   Carniciu, Simona
   Mitu, Manuela
   Guja, Cristian
   Ionescu-Tirgoviste, Constantin
TI Negative association between paraoxonase 2, anthropometric markers and
   metabolic syndrome
SO OPEN LIFE SCIENCES
LA English
DT Article
DE type 2 diabetes; metabolic syndrome; paraoxonase 2; total oxidant and
   antioxidant status
ID LOW-DENSITY-LIPOPROTEIN; OXIDATIVE STRESS; SERUM PARAOXONASE; PROTEIN;
   PLASMA; COMPLICATIONS; CHOLESTEROL; GENERATION; GLUCOSE; PON3
AB Background Metabolic syndrome (MS) has a great impact on cardiovascular mortality and morbidity. Our aim was to investigate the association of MS with some oxidant and antioxidant markers, including pro- and antioxidant status of peripheral blood mononuclear cells (PBMC) in newly diagnosed type 2 diabetic mellitus patients (ND-T2D).
   Methods 219 ND-T2D and 88 healthy subjects were divided in two groups according to the absence or presence of MS. Anthropometric measurements, routine blood tests, total oxidant status (TOS), total antioxidant status (TAS) and ELISA measurements were included. The PBMC capacity to release free radicals and to neutralize them was also determined by measuring the respiratory burst (RB) together with the lactonase activity of the intracellular antioxidant enzyme paraoxonase 2 (PON2).
   Results Comparing ND-T2D MS+ with those MS-the RB of the PBMC was significantly higher (p<0.05) while lactonase PON2 enzymatic activity was decreased (p < 0.001). A negative correlation of RB was found with TAS (r = -0.416, p < 0.05). PON2 was also negatively correlated with glycaemia (r = -0.275, p < 0.001), HbA(1c) (r = -0.308, p < 0.001), weight (r = -0.183; p < 0.05), waist circumference (r = -0.353, p < 0.001) and body mass index (r = -0.290, p < 0.001).
   Conclusion PON2 lactonase activity is negatively associated with anthropometric markers in ND-T2D with MS.
C1 [Lixandru, Daniela; Alexandru, Petruta] Romanian Acad, Dept Mol Cell Biol, Inst Biochem, Bucharest, Romania.
   [Mihai, Andrada; Carniciu, Simona; Mitu, Manuela; Guja, Cristian; Ionescu-Tirgoviste, Constantin] NIDNMD Prof NC Paulescu, Bucharest, Romania.
C3 Romanian Academy; Nicolae Simionescu Institute of Cellular Biology &
   Pathology; Institute of Biochemistry, Bucharest
RP Lixandru, D (corresponding author), Univ Med & Pharm Carol Davila, Bucharest, Romania.
EM daniela.lixandru@umf.ro
RI Lixandru, Daniela/U-4330-2017; Guja, Cristian/K-2334-2019; Stoian,
   Irina/H-5789-2011; Mihai, Doina Andrada/JZT-5214-2024; Petruta-ramona,
   Alexandru/JRW-0573-2023
OI Stoian, Irina/0000-0002-0271-9946; /0009-0008-4925-2221
FU Romanian National Authority for Scientific Research, CNCS-UEFISCDI
   [PN-II-ID-PCE-2011-3-0429]; European Social Fund [POSDRU/89/1.5/S/60746,
   POSDRU/107/1.5/S/82514]
FX This work was supported by a grant from the Romanian National Authority
   for Scientific Research, CNCS-UEFISCDI, project number
   PN-II-ID-PCE-2011-3-0429. Dr. Daniela Lixandru was also supported by the
   postdoctoral program POSDRU/89/1.5/S/60746 and Petruta Alexandru by the
   program POSDRU/107/1.5/S/82514 from European Social Fund. We gratefully
   acknowledge Laura Petcu, Ariana Picu and Janeta Tudosoiu from the
   research laboratory of NIDNMD "Prof. N. Paulescu", for excellent
   technical assistance in conducting the clinical study.
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NR 30
TC 0
Z9 0
U1 0
U2 4
PU DE GRUYTER POLAND SP ZOO
PI WARSAW
PA BOGUMILA ZUGA 32A STR., 01-811 WARSAW, POLAND
SN 2391-5412
J9 OPEN LIFE SCI
JI Open Life Sci.
PD JAN
PY 2015
VL 10
IS 1
BP 365
EP 371
DI 10.1515/biol-2015-0037
PG 7
WC Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics
GA DF6OR
UT WOS:000371475600010
OA gold
DA 2025-06-11
ER

PT J
AU Zák, A
   Burda, M
   Vecka, M
   Zeman, M
   Tvrzická, E
   Stanková, B
AF Zak, A.
   Burda, M.
   Vecka, M.
   Zeman, M.
   Tvrzicka, E.
   Stankova, B.
TI Fatty Acid Composition Indicates Two Types of Metabolic Syndrome
   Independent of Clinical and Laboratory Parameters
SO PHYSIOLOGICAL RESEARCH
LA English
DT Article
DE Metabolic syndrome; Fatty acids; Delta desaturase activities; Cluster
   analysis
ID ESTIMATED DESATURASE ACTIVITIES; INSULIN-RESISTANCE; PALMITOLEIC ACID;
   PLASMA-GLUCOSE; SERUM-LIPIDS; DIETARY-FAT; RISK; OBESITY; INFLAMMATION;
   POPULATION
AB Dietary composition and metabolism of fatty acids (FA) influence insulin resistance, atherogenic dyslipidemia and other components of the metabolic syndrome (MS). It is known that patients with MS exhibit a heterogeneous phenotype; however, the relationships of individual FA to MS components have not yet been consistently studied. We examined the plasma phosphatidylcholine FA composition of 166 individuals (68F/98M) with MS and of 188 (87F/101M) controls. Cluster analysis of FA divided the groups into two clusters. In cluster 1, there were 65.7 % of MS patients and 37.8 % of controls, cluster 2 contained 34.3 % of patients and 62.2 % of controls (P<0.001). Those with MS within cluster 1 (MS1) differed from individuals with MS in cluster 2 (MS2) by concentrations of glucose (P<0.05), NEFA (P<0.001), HOMA-IR (P<0.05), and levels of conjugated dienes in LDL (P<0.05). The FA composition in MS1 group differed from MS2 by higher contents of palmitoleic (+30 %), gamma-linolenic (+22 %), dihomo-gamma-linolenic (+9 %) acids and by a lower content of linoleic acid(-25 %) (all P<0.01). These FA patterns are supposed to be connected with the progression and/ or impaired biochemical measures of MS (lipolysis, oxidative stress, dysglycidemia, and insulin resistance).
C1 [Zak, A.; Vecka, M.; Zeman, M.; Tvrzicka, E.; Stankova, B.] Charles Univ Prague, Fac Med 1, Dept Med 4, Gen Univ Hosp Prague, U Nemocnice 2, Prague 12808 2, Czech Republic.
   [Burda, M.] Univ Ostrava, Ctr Excellence IT4Innovat, Inst Res & Applicat Fuzzy Modeling, Ostrava, Czech Republic.
C3 Charles University Prague; General University Hospital Prague;
   University of Ostrava
RP Zák, A (corresponding author), Charles Univ Prague, Fac Med 1, Dept Med 4, Gen Univ Hosp Prague, U Nemocnice 2, Prague 12808 2, Czech Republic.
EM azak@vfn.cz
RI Stankova, Barbora/L-7933-2016; Burda, Michal/D-6699-2014; Tvrzicka,
   Eva/Q-6300-2016; Vecka, Marek/A-3560-2008; Zak, Ales/G-8318-2016; Zeman,
   Miroslav/J-5281-2016
OI Burda, Michal/0000-0002-4182-4407; Tvrzicka, Eva/0000-0003-0794-8454;
   Vecka, Marek/0000-0002-3269-1817; Zak, Ales/0000-0002-1698-6068; Zeman,
   Miroslav/0000-0001-5338-603X
FU IGA, Ministry of Health [NT/13199]; Czech Republic [RVO VFN64165/2012,
   PRVOUK P25/LF1/2]; European Regional Development Fund in the project of
   IT4 Innovations Centre of Excellence [CZ. 1.05/1.1.00/02.0070, VP6]
FX This research was supported by the grant NT/13199, IGA, Ministry of
   Health, the Czech Republic, RVO VFN64165/2012, PRVOUK P25/LF1/2, and by
   the European Regional Development Fund in the project of IT4 Innovations
   Centre of Excellence (CZ. 1.05/1.1.00/02.0070, VP6).
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NR 45
TC 13
Z9 14
U1 0
U2 12
PU ACAD SCIENCES CZECH REPUBLIC, INST PHYSIOLOGY
PI PRAGUE 4
PA VIDENSKA 1083, PRAGUE 4 142 20, CZECH REPUBLIC
SN 0862-8408
EI 1802-9973
J9 PHYSIOL RES
JI Physiol. Res.
PY 2014
VL 63
SU 3
BP S375
EP S385
DI 10.33549/physiolres.932868
PG 11
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA AU4OO
UT WOS:000345591100008
PM 25428743
OA gold
DA 2025-06-11
ER

PT J
AU Nizami, HL
   Katare, P
   Prabhakar, P
   Kumar, Y
   Arava, SK
   Chakraborty, P
   Maulik, SK
   Banerjee, SK
AF Nizami, Hina Lateef
   Katare, Parmeshwar
   Prabhakar, Pankaj
   Kumar, Yashwant
   Arava, Sudheer Kumar
   Chakraborty, Praloy
   Maulik, Subir Kumar
   Banerjee, Sanjay Kumar
TI Vitamin D Deficiency in Rats Causes Cardiac Dysfunction by Inducing
   Myocardial Insulin Resistance
SO MOLECULAR NUTRITION & FOOD RESEARCH
LA English
DT Article
DE cardiac remodeling; heart failure; insulin resistance; metabolic
   syndrome; vitamin D deficiency
ID HIGH-FAT DIET; OXIDATIVE STRESS; METABOLIC SYNDROME; HEART-FAILURE;
   INDUCED OBESITY; ADIPOSE-TISSUE; D-RECEPTOR; HYPERTROPHY; ASSOCIATION;
   EXPRESSION
AB Scope Cause-effect relationship between vitamin D deficiency and cardiometabolic abnormalities remains undefined. The aim is to investigate the role of vitamin D deficiency in cardiac failure, through possible involvement in myocardial insulin signaling. Methods and results Male SD rats (n = 6) are fed a normal diet (Con), vitamin D-deficient diet [Con(-)], or high-fat, high fructose diet (HFHFrD) for 20 weeks. Cardiac hypertrophy and fetal gene program are confirmed in Con(-) group. Cardiac dysfunction is assessed by echocardiography. Elevated renin, TGF-beta and collagen-1 alpha mRNAs, p-ERK1/2, and perivascular fibrosis indicate cardiac remodeling in Con(-) group. Increased serum insulin, triglycerides, and blood pressure, and decreased glucose tolerance and HDL cholesterol are observed in Con(-) rats. Decreased p-Akt/Akt, GLUT4, SOD2, and catalase, and increased NF-kappa B, TNF-alpha, and IL-6 are observed in Con(-) hearts. In H9c2 cells, calcitriol attenuates palmitate-induced insulin resistance. VDR-silenced H9c2 cells show reduced Akt phosphorylation, GLUT4 translocation, and 2-NBDG uptake. Findings in Con(-) and HFHFrD groups are comparable. Conclusion Vitamin D deficiency in rats mimic high-fat-, high-fructose-induced metabolic syndrome and cardiac dysfunction. This study demonstrates that vitamin D deficiency is an independent risk factor for heart failure, at least in part, through induction of myocardial insulin resistance.
C1 [Nizami, Hina Lateef; Katare, Parmeshwar; Kumar, Yashwant; Banerjee, Sanjay Kumar] Translat Hlth Sci & Technol Inst, Drug Discovery Res Ctr, Faridabad 121001, India.
   [Prabhakar, Pankaj; Maulik, Subir Kumar] All India Inst Med Sci, Dept Pharmacol, New Delhi 110029, India.
   [Arava, Sudheer Kumar] All India Inst Med Sci, Dept Pathol, New Delhi 110029, India.
   [Chakraborty, Praloy] VMMC, Dept Cardiol, New Delhi 110029, India.
   [Chakraborty, Praloy] Safdarjang Hosp, New Delhi 110029, India.
C3 Department of Biotechnology (DBT) India; Translational Health Science &
   Technology Institute (THSTI); All India Institute of Medical Sciences
   (AIIMS) New Delhi; All India Institute of Medical Sciences (AIIMS) New
   Delhi; Vardhman Mahavir Medical College & Safdarjung Hospital; Vardhman
   Mahavir Medical College & Safdarjung Hospital
RP Banerjee, SK (corresponding author), Translat Hlth Sci & Technol Inst, Drug Discovery Res Ctr, Faridabad 121001, India.
EM skbanerjee@thsti.res.in
RI Arava, Sudheer/AAF-7593-2020; Prabhakar, Dr. Pankaj/GOH-1003-2022;
   Banaś, Elżbieta/W-4583-2017; Banerjee, Sanjay/F-2677-2019
OI Banerjee, Sanjay k/0000-0002-0044-0984; Banerjee,
   Sanjay/0000-0002-4478-7189; Banerjee, Sanjay/0000-0002-0008-0480;
   Prabhakar, Dr. Pankaj/0000-0002-1630-4258
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NR 40
TC 26
Z9 26
U1 0
U2 8
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1613-4125
EI 1613-4133
J9 MOL NUTR FOOD RES
JI Mol. Nutr. Food Res.
PD SEP
PY 2019
VL 63
IS 17
AR 1900109
DI 10.1002/mnfr.201900109
PG 12
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA IX8IZ
UT WOS:000485931500010
PM 31095894
DA 2025-06-11
ER

PT J
AU Wu, HT
   Liu, CC
   Dong, JH
   Lai, CJ
   Chen, DY
   Sun, CK
   Chen, JJ
AF Wu, Hsien-Tsai
   Liu, Cyuan-Cin
   Dong, Jyun-Hao
   Lai, Ching Jung
   Chen, Ding-Yuan
   Sun, Cheuk-Kwan
   Chen, Jian-Jung
TI CAROTENOIDS IN RELATION TO MARKERS OF ENDOTHELIAL FUNCTION AND
   ATHEROSCLEROSIS IN YOUNG PEOPLE
SO CURRENT TOPICS IN NUTRACEUTICAL RESEARCH
LA English
DT Article
DE Arterial stiffness; Cardiovascular disease; Carotenoids; Endothelial
   function
ID CORONARY-HEART-DISEASE; PULSE-WAVE VELOCITY; METABOLIC SYNDROME;
   ARTERIAL STIFFNESS; PLASMA CAROTENOIDS; SERUM CAROTENOIDS; OXIDATIVE
   STRESS; ADULTS; VITAMINS; RISK
AB This study aimed at observing the relationship between carotenoids status, parameters of metabolic syndrome, and vascular health prior to changing their dietary condition, i.e. eating out. This study consisted of two parts. In Part A study, the skin carotenoids counts (SCC) of three different groups, Group I: young people (n=20), Group 2: upper mid-aged people (n=14), and Group 3: diabetics (n=17), were obtained and compared Although Group I appeared to be the youngest, the SCC was much lower than that of Group 2 (19619 +/- 11147 vs. 32571 +/- 4351) but close to that of Group 3 (18974 +/- 9089). As far as vascular health was concerned it was not statistically different between Group I and Group 2 In Part B study, SCC, pulse wave velocity (PWVfoot), and dilatation index (DI) of healthy young subjects (Group 4, n=14) were measured for three consecutive months with their dietary condition remaining unchanged Although there was no significant difference between the abovementioned values, the SCC were still significantly correlated with the parameters of metabolic syndrome factor and PWVfoot (r=-0.435, P=0.001). With their dietary condition remaining unchanged for three consecutive months, Group 4 exhibited no significant improvement in either the SCC or parameters of vascular health.
C1 [Wu, Hsien-Tsai; Liu, Cyuan-Cin; Dong, Jyun-Hao] Natl Dong Hwa Univ, Dept Elect Engn, Hualien, Taiwan.
   [Lai, Ching Jung] Tzu Chi Univ, Sch Med, Dept Physiol, Hualien, Taiwan.
   [Chen, Ding-Yuan] Hualien Hosp, Dept Urol, Hualien, Taiwan.
   [Sun, Cheuk-Kwan] I Shou Univ, E Da Hosp, Dept Emergency Med, Kaohsiung, Taiwan.
   [Chen, Jian-Jung] Buddhist Tzu Chi Gen Hosp, Taichung Branch, Dept Chinese Med, Taichung, Taiwan.
   [Chen, Jian-Jung] Tzu Chi Univ, Sch Chinese Med, Hualien, Taiwan.
C3 National Dong Hwa University; Tzu Chi University; I Shou University;
   E-Da Hospital; Buddhist Tzu Chi General Hospital; Taichung Tzu Chi
   Hospital; Tzu Chi University
RP Chen, JJ (corresponding author), Tzu Chi Univ, Dept Chinese Med, Buddhist Tzu Chi Gen Hosp, Taichung Branch, 66,Sec 1,Fongsing Rd, Tanzih Township 427, Taichung County, Taiwan.
EM hsientsaiwu@gmail.com; cjjwei@ms34.hinet.net
RI Wu, Hsien-Tsai/X-4730-2019; CHEN, Jianhui/D-1338-2009; Sun,
   Cheuk-Kwan/K-5723-2012
OI Wu, Hsientsai/0000-0002-2581-9384
FU National Science Council, Taiwan, Republic of China [NSC
   100-2221-E-259-030-MY2]; National Dong Hwa University on campus
   interdisciplinary integration project [101T924-3, 102T931-3]
FX The authors would like to thank the volunteers involved in this study
   for allowing us to collect and analyze their data. This research was
   partly supported by National Science Council under Grand NSC
   100-2221-E-259-030-MY2, Taiwan, Republic of China and National Dong Hwa
   University on campus interdisciplinary integration project no. 101T924-3
   and 102T931-3.
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NR 31
TC 0
Z9 0
U1 0
U2 2
PU NEW CENTURY HEALTH PUBLISHERS, LLC
PI COPPELL
PA PO BOX 175, COPPELL, TX 75019 USA
SN 1540-7535
J9 CURR TOP NUTRACEUT R
JI Curr. Top. Nutraceutical Res.
PD AUG
PY 2013
VL 11
IS 3
BP 83
EP 90
PG 8
WC Nutrition & Dietetics; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics; Pharmacology & Pharmacy
GA AF3ZE
UT WOS:000334650400003
DA 2025-06-11
ER

PT J
AU Gauthier, H
   Zedet, M
   Wahab, A
   Baldé, S
   Bapst, B
   Lafont, C
   Créange, A
AF Gauthier, H.
   Zedet, M.
   Wahab, A.
   Balde, S.
   Bapst, B.
   Lafont, C.
   Creange, A.
TI Metabolic syndrome and the phenotype of multiple
SO REVUE NEUROLOGIQUE
LA English
DT Article
DE Multiple sclerosis; Metabolic syndrome; Relapsing-remitting multiple;
   sclerosis; Secondary progressive multiple; Abdominal obesity; Waist
   circumference
ID OXIDATIVE STRESS; SCLEROSIS; COMORBIDITY; PROGRESSION; PREVALENCE;
   DIAGNOSIS; DISEASE; DAMAGE
AB Background. - Comorbidities, particularly vascular comorbidities, have been shown to exacerbate the progression of disability in multiple sclerosis (MS). Metabolic syndrome (MetS) is a cluster of conditions including abdominal obesity, insulin resistance, atherogenic dyslipidemia, and vascular dysfunction, which contribute to vascular morbidity and chronic inflammation. Objective. - To describe the characteristics of MetS in a cohort of MS patients and evaluate its relationship with the MS phenotype. Methods. - A monocentric cohort study was conducted on MS patients, collecting demographic, clinical, radiological, and therapeutic data, as well as metabolic data including waist circumference, blood pressure, serum triglycerides, high-density lipoprotein cholesterol, and fasting blood glucose. Results. - Among the 84 patients included in the study, 27% were diagnosed with MetS. MetS was found to be associated with secondary progressive MS (SPMS). Patients with SPMS had a higher prevalence of MetS compared to those with relapsing-remitting MS (RRMS), even after adjusting for disease duration. While MetS was associated with Expanded Disability Status Scale (EDSS) progression in the 3-year period according to univariate analysis, it did not show a significant association with disease activity. Conclusion. - This study provides evidence supporting the connection between MetS and the progression of disability in MS, independent of disease relapse activity. (c) 2024 The Authors. Published by Elsevier Masson SAS. This is an open access article under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).
C1 [Gauthier, H.; Zedet, M.; Wahab, A.; Creange, A.] Hop Henri Mondor, Ctr hosp Univ Henri Mondor, AP HP, Serv neurol, 51 Ave Marechal Delattre Detassigny, F-94010 Creteil, France.
   [Gauthier, H.; Zedet, M.; Wahab, A.; Balde, S.; Bapst, B.; Creange, A.] Hop Henri Mondor, AP HP, Creteil, Paris, France.
   [Zedet, M.; Wahab, A.; Bapst, B.; Creange, A.] Univ Paris Est, EA4391, Creteil, France.
   [Bapst, B.] Hop Henri Mondor, AP HP, Serv neuroradiol, Creteil, France.
   [Lafont, C.] Univ Paris Est Creteil, Inserm, IMRB, F-94010 Creteil, France.
   [Lafont, C.] Hop Henri Mondor, AP HP, Serv Sante publ, F-94010 Creteil, France.
C3 Assistance Publique Hopitaux Paris (APHP); Universite
   Paris-Est-Creteil-Val-de-Marne (UPEC); Hopital Universitaire
   Henri-Mondor - APHP; Universite Paris-Est-Creteil-Val-de-Marne (UPEC);
   Assistance Publique Hopitaux Paris (APHP); Hopital Universitaire
   Henri-Mondor - APHP; Universite Paris-Est-Creteil-Val-de-Marne (UPEC);
   Assistance Publique Hopitaux Paris (APHP); Universite
   Paris-Est-Creteil-Val-de-Marne (UPEC); Hopital Universitaire
   Henri-Mondor - APHP; Institut National de la Sante et de la Recherche
   Medicale (Inserm); Universite Paris-Est-Creteil-Val-de-Marne (UPEC);
   Assistance Publique Hopitaux Paris (APHP); Universite
   Paris-Est-Creteil-Val-de-Marne (UPEC); Hopital Universitaire
   Henri-Mondor - APHP
RP Créange, A (corresponding author), Hop Henri Mondor, Ctr hosp Univ Henri Mondor, AP HP, Serv neurol, 51 Ave Marechal Delattre Detassigny, F-94010 Creteil, France.
RI Lafont, Charlotte/LGY-4215-2024
FU French State by the "Agence Nationale de la Recherche"
   [ANR-10-COHO-002]; Eugene Devic EDMUS Foundation; ARSEP Foundation
FX The authors thank the Observatoire francais de la Sclerose en plaques
   (OFSEP) which is supported by a grant provided by the French State and
   handled by the "Agence Nationale de la Recherche", within the framework
   of the "Investments for the Future" program, under the reference
   ANR-10-COHO-002, by the Eugene Devic EDMUS Foundation against multiple
   sclerosis and by the ARSEP Foundation.
CR Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
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NR 35
TC 1
Z9 1
U1 0
U2 0
PU MASSON EDITEUR
PI MOULINEAUX CEDEX 9
PA 21 STREET CAMILLE DESMOULINS, ISSY, 92789 MOULINEAUX CEDEX 9, FRANCE
SN 0035-3787
EI 2213-0004
J9 REV NEUROL-FRANCE
JI Rev. Neurol.
PD SEP
PY 2024
VL 180
IS 7
BP 673
EP 681
DI 10.1016/j.neurol.2024.03.009
EA AUG 2024
PG 9
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA E0O8K
UT WOS:001300094900001
PM 38729781
OA hybrid
DA 2025-06-11
ER

PT J
AU Yorulmaz, E
   Uzunlulu, M
   Yorulmaz, H
   Oguz, A
AF Yorulmaz, Elif
   Uzunlulu, Mehmet
   Yorulmaz, Hatice
   Oguz, Aytekin
TI Relationship between uric acid levels and impaired glucose tolerance in
   subjects with metabolic syndrome
SO PAKISTAN JOURNAL OF MEDICAL SCIENCES
LA English
DT Article
DE Metabolic syndrome; Uric acid; Glucose intolerance
ID CARDIOVASCULAR RISK-FACTORS; MORTALITY; ATHEROSCLEROSIS; PREVALENCE;
   RESISTANCE; DISEASE; STRESS; MEN
AB Objective: Metabolic syndrome (MetS) is a clustering of cardio-metabolic risk factors. Elevated serum uric acid levels are frequent in cases with cardiovascular disease carrying many attributes of MetS. The role of uric acid in the MetS pathogenesis and the development of Type 2 Diabetes Mellitus (DM) was not fully understood. In this study, the relationship between serum uric acid levels and MetS criteria and oral glucose tolerance test (OGTT) results was studied.
   Methodology: This study was carried out in 83 patients having at least three MetS diagnosis criteria recommended by National Cholesterol Education Program Adult Treatment Panel III. After collecting 12-hour fasting venous blood samples of subjects, 2-hour OGTT was performed with 75 g oral glucose. A glucose level between 140 and 199 mg/dl at hour 2 was defined as impaired glucose tolerance.
   Results: The 2-hour glucose value of 25 cases (31%) out of 83 cases was determined to be 140 mg/dl and over. In the multiple linear regression analysis, it was found that uric acid level and waist circumference, and body mass index and 2-hour OGTT levels were significantly related.
   Conclusion: In this study, in cases having high risk for type 2 DM, it was found that uric acid levels were related by some MetS components. Uric acid concentrations did not effect basal glycemia and insulin sensitivity.
C1 [Yorulmaz, Elif] Goztepe Training & Res Hosp, Dept Gastroenterol, Istanbul, Turkey.
   [Uzunlulu, Mehmet; Oguz, Aytekin] Goztepe Training & Res Hosp, Dept Internal Med, Istanbul, Turkey.
   [Yorulmaz, Hatice] Halic Univ, Sch Hlth Sci, Dept Physiotherapy, Istanbul, Turkey.
   [Yorulmaz, Hatice] Halic Univ, Sch Hlth Sci, Dept Rehabil, Istanbul, Turkey.
C3 Istanbul Goztepe Training & Research Hospital; Istanbul Goztepe Training
   & Research Hospital; Halic University; Halic University
RP Yorulmaz, H (corresponding author), Daruleceze Ave,14 Okmeydani, Istanbul, Turkey.
EM haticeyorulmaz@gmail.com
RI Uzunlulu, Mehmet/KYR-8040-2024; Oguz, Aytekin/AAJ-2732-2021
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NR 22
TC 0
Z9 0
U1 0
U2 0
PU PROFESSIONAL MEDICAL PUBLICATIONS
PI SADDAR
PA PANORAMA CENTRE, RM 522, 5TH FLOOR, BLDG 2, RAJA GHAZANFAR ALI RD, PO
   BOX 8766, SADDAR, KARACHI 00000, PAKISTAN
SN 1682-024X
J9 PAK J MED SCI
JI Pak. J. Med. Sci.
PD APR-JUN
PY 2011
VL 27
IS 2
BP 286
EP 289
PG 4
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 780BX
UT WOS:000291827700013
DA 2025-06-11
ER

PT J
AU Toblli, JE
   Ferrini, MG
   Cao, G
   Vernet, D
   Angerosa, M
   Gonzalez-Cadavid, NF
AF Toblli, Jorge E.
   Ferrini, Monica G.
   Cao, Gabriel
   Vernet, Dolores
   Angerosa, Margarita
   Gonzalez-Cadavid, Nestor F.
TI Antifibrotic effects of pioglitazone on the kidney in a rat model of
   type 2 diabetes mellitus
SO NEPHROLOGY DIALYSIS TRANSPLANTATION
LA English
DT Article
DE diabetic nephropathy; fibrosis; inflammation; oxidative stress;
   thiazolidinediones
ID OBESE ZUCKER RATS; RECEPTOR-GAMMA AGONIST; CORPORAL VENOOCCLUSIVE
   DYSFUNCTION; PLASMINOGEN-ACTIVATOR INHIBITOR-1; CONVERTING
   ENZYME-INHIBITION; FATTY RATS; OXIDATIVE STRESS; INSULIN-RESISTANCE;
   METABOLIC SYNDROME; RENAL PROTECTION
AB Background. Recent evidence suggests that treatment of type 2 diabetes with thiazolidinediones [peroxisome proliferator-activated receptor-gamma (PPAR-gamma) agonists], ameliorates glomerulosclerosis and tubulointerstitial fibrosis in the rat kidney. In the current work, we have investigated whether these drugs, and specifically pioglitazone (PGT), act by preventing fibrosis and kidney dysfunction mainly through antioxidant and anti-inflammatory effects, independently of glycaemic control.
   Methods. Male 2- to 3-month-old obese Zucker fa/fa (OZR) and ZDF fa/fa rats (ZDFR), and their control the lean Zucker rat (LZR), were used. Diabetic rats were given either a low dose (0.6 mg/kg/day) or a high dose (12 mg/kg/day) of PGT in the chow for 2 or 4-5 months. Glycaemia, blood pressure, creatinine clearance and proteinuria were determined, and the underlying histopathology was defined with markers of fibrosis, glomerular damage, oxidative stress and inflammation by immunohistochemistry/quantitative image analysis in tissue sections, and western blots and ad hoc assays in fresh tissue.
   Results. PGT at low doses given for 4-5 months considerably reduced blood pressure, proteinuria and creatinine clearance. This was associated with amelioration of renal tissue damage and fibrosis, evidenced by the glomerulosclerosis, tubulointerstitial fibrosis, tubular atrophy and podocyte injury indexes, and of oxidative stress and inflammation, as shown by the decrease in the respective markers, although glycaemia remained high and obesity was not affected.
   Conclusions. These results indicate that low doses of PGT ameliorate renal fibrosis and preserve renal function in this animal model of metabolic syndrome, independently of glycaemic control or effects on body weight.
C1 [Ferrini, Monica G.; Vernet, Dolores; Gonzalez-Cadavid, Nestor F.] Harbor UCLA Med Ctr, Los Angeles Biomed Res Inst, Urol Res Lab, Torrance, CA 90509 USA.
   [Toblli, Jorge E.; Cao, Gabriel; Angerosa, Margarita] Hosp Aleman, Expt Med Lab, Buenos Aires, DF, Argentina.
   [Ferrini, Monica G.; Vernet, Dolores; Gonzalez-Cadavid, Nestor F.] Charles Drew Univ, Dept Internal Med, Torrance, CA USA.
   [Gonzalez-Cadavid, Nestor F.] Univ Calif Los Angeles, David Geffen Sch Med, Dept Urol, Torrance, CA USA.
C3 University of California System; University of California Los Angeles;
   University of California Los Angeles Medical Center; Lundquist
   Institute; University of Buenos Aires; University of Buenos Aires
   Hospital; Hospital Aleman; Charles R. Drew University of Medicine &
   Science; University of California System; University of California Los
   Angeles; University of California Los Angeles Medical Center; David
   Geffen School of Medicine at UCLA
RP Gonzalez-Cadavid, NF (corresponding author), Harbor UCLA Med Ctr, Los Angeles Biomed Res Inst, Urol Res Lab, Torrance, CA 90509 USA.
EM ncadavid@ucla.edu
RI Cao, Gabriel/LJL-8755-2024
FU Takeda Pharmaceuticals North America, Inc.; American Diabetes
   Association [7-05-RA-44 ADA];  [NIHR01 DK53069]
FX This work was supported by an investigator-initiated grant from Takeda
   Pharmaceuticals North America, Inc., and (in part) American Diabetes
   Association grant #7-05-RA-44 ADA, and NIHR01 DK53069 to N.G.C.
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NR 48
TC 54
Z9 65
U1 0
U2 6
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0931-0509
EI 1460-2385
J9 NEPHROL DIAL TRANSPL
JI Nephrol. Dial. Transplant.
PD AUG
PY 2009
VL 24
IS 8
BP 2384
EP 2391
DI 10.1093/ndt/gfp103
PG 8
WC Transplantation; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Transplantation; Urology & Nephrology
GA 472FN
UT WOS:000268115400016
PM 19297362
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Klobucar, I
   Hofmann, L
   Habisch, H
   Lechleitner, M
   Klobucar, L
   Trbusic, M
   Pregartner, G
   Berghold, A
   Madl, T
   Frank, S
   Degoricija, V
AF Klobucar, Iva
   Hofmann, Lidija
   Habisch, Hansjoerg
   Lechleitner, Margarete
   Klobucar, Lucija
   Trbusic, Matias
   Pregartner, Gudrun
   Berghold, Andrea
   Madl, Tobias
   Frank, Sasa
   Degoricija, Vesna
TI Advanced Oxidation Protein Products Are Strongly Associated with the
   Serum Levels and Lipid Contents of Lipoprotein Subclasses in Healthy
   Volunteers and Patients with Metabolic Syndrome
SO ANTIOXIDANTS
LA English
DT Article
DE NMR spectroscopy; lipoprotein profiling; advanced oxidation protein
   products; metabolic syndrome
ID DENSE HDL3 PARTICLES; IN-VITRO OXIDATION; RISK-FACTORS; STRESS;
   SUSCEPTIBILITY; LDL; ATHEROSCLEROSIS; HETEROGENEITY; SUBFRACTIONS;
   COMPONENTS
AB The association between advanced oxidation protein products (AOPPs) and lipoprotein subclasses remains unexplored. Therefore, we performed comprehensive lipoprotein profiling of serum using NMR spectroscopy and examined the associations of lipoprotein subclasses with the serum levels of AOPPs in healthy volunteers (HVs) and patients with metabolic syndrome (MS). The serum levels of AOPPs were significantly positively correlated with the serum levels of very-low-density lipoprotein (VLDL), intermediate-density lipoprotein (IDL), and low-density lipoprotein (LDL); however, they were significantly negatively correlated with high-density lipoprotein (HDL). These lipoproteins (and their subclasses) differed markedly regarding the direction of correlations between their lipid contents and AOPPs. The strength of the correlations and the relative contributions of the subclasses to the correlations were different in the HVs and patients with MS. As revealed by orthogonal partial least squares discriminant analyses, the serum levels of IDL were strong determinants of AOPPs in the HVs, whereas the serum levels of VLDL and the lipid content of LDL were strong determinants in both groups. We conclude that IDL, VLDL, and LDL facilitate, whereas HDL diminishes the bioavailability of serum AOPPs. The presence of MS and the lipid contents of the subclasses affect the relationship between lipoproteins and AOPPs.
C1 [Klobucar, Iva; Trbusic, Matias] Sisters Char Univ Hosp Ctr, Dept Cardiol, Zagreb 10000, Croatia.
   [Hofmann, Lidija] FH JOANNEUM Univ Appl Sci, Inst Biomed Sci, Dept Hlth Studies, A-8020 Graz, Austria.
   [Habisch, Hansjoerg; Madl, Tobias] Med Univ Graz, Otto Loewi Res Ctr, Med Chem, A-8010 Graz, Austria.
   [Lechleitner, Margarete; Frank, Sasa] Med Univ Graz, Gottfried Schatz Res Ctr, Mol Biol & Biochem, A-8010 Graz, Austria.
   [Klobucar, Lucija] Univ Hosp Ctr Osijek, Dept Med, Osijek 31000, Croatia.
   [Trbusic, Matias; Degoricija, Vesna] Univ Zagreb, Sch Med, Zagreb 10000, Croatia.
   [Pregartner, Gudrun; Berghold, Andrea] Med Univ Graz, Inst Med Informat Stat & Documentat, A-8036 Graz, Austria.
   [Madl, Tobias; Frank, Sasa] BioTechMed Graz, A-8010 Graz, Austria.
   [Degoricija, Vesna] Sisters Char Univ Hosp Ctr, Dept Med, Zagreb 10000, Croatia.
C3 Medical University of Graz; Medical University of Graz; University of
   Zagreb; Medical University of Graz
RP Frank, S (corresponding author), Med Univ Graz, Gottfried Schatz Res Ctr, Mol Biol & Biochem, A-8010 Graz, Austria.; Frank, S (corresponding author), BioTechMed Graz, A-8010 Graz, Austria.
EM iva.klobucar@gmail.com; lidija.hofmann@fh-joanneum.at;
   hansjoerg.habisch@medunigraz.at; margarete.lechleitner@medunigraz.at;
   klobucar.lucija@gmail.com; matias.trbusic@gmail.com;
   gudrun.pregartner@medunigraz.at; andrea.berghold@medunigraz.at;
   tobias.madl@medunigraz.at; sasa.frank@medunigraz.at;
   vesna.degoricija@mef.hr
RI Klobučar, Iva/JHS-6524-2023; Madl, Tobias/B-1682-2012
OI Frank, Sasa/0000-0003-4826-7698; Klobucar, Iva/0000-0002-0640-7149;
   Habisch, Hansjorg/0000-0001-5537-506X
FU Austrian Science Fund (FWF)
FX No Statement Available
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NR 57
TC 1
Z9 1
U1 0
U2 2
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD MAR
PY 2024
VL 13
IS 3
AR 339
DI 10.3390/antiox13030339
PG 21
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA MC9Y5
UT WOS:001191557400001
PM 38539872
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Liu, BY
   Xue, JL
   Zhang, MY
   Wang, MY
   Ma, TT
   Zhao, M
   Gu, QQ
   Qin, SC
AF Liu, Boyan
   Xue, Junli
   Zhang, Mengyu
   Wang, Mingyue
   Ma, Tingting
   Zhao, Min
   Gu, Qianqian
   Qin, Shucun
TI Hydrogen inhalation alleviates nonalcoholic fatty liver disease in
   metabolic syndrome rats
SO MOLECULAR MEDICINE REPORTS
LA English
DT Article
DE molecular hydrogen; metabolic syndrome; nonalcoholic fatty liver
   disease; lipid metabolism
ID RICH WATER; AMERICAN ASSOCIATION; INSULIN-RESISTANCE; CHOLESTEROL
   LEVELS; OXIDATIVE STRESS; GENE-EXPRESSION; PPAR-ALPHA; VITAMIN-E;
   STEATOHEPATITIS; ANTIOXIDANT
AB Hydrogen exhibits therapeutic and preventive effects against various diseases. The present study investigated the potential protective effect and dose-dependent manner of hydrogen inhalation on high fat and fructose diet (HFFD)-induced nonalcoholic fatty liver disease (NAFLD) in Sprague-Dawley rats. Rats were randomly divided into four groups: i) Control group, regular diet/air inhalation; ii) model group, HFFD/air inhalation; iii) low hydrogen group, HFFD/4% hydrogen inhalation; and iv) high hydrogen group, HFFD/67% hydrogen inhalation. After a 10-week experiment, hydrogen inhalation ameliorated weight gain, abdominal fat index, liver index and body mass index of rats fed with HFFD and lowered the total area under the curve in an oral glucose tolerance test. Hydrogen inhalation also ameliorated the increase in liver lipid content and alanine transaminase and aspartate transaminase activities. Liver histopathologic changes evaluated with hematoxylin and eosin as well as Oil Red O staining revealed lower lipid deposition in hydrogen inhalation groups, consistent with the decrease in the expression of the lipid synthesis gene SREBP-1c. The majority of the indicators were affected following treatment with hydrogen in a dose-dependent manner. In conclusion, hydrogen inhalation may play a protective role by influencing the general state, lipid metabolism parameters, liver histology and liver function indicators in the rat model of metabolic syndrome with NAFLD.
C1 [Liu, Boyan; Xue, Junli; Zhang, Mengyu; Wang, Mingyue; Ma, Tingting; Zhao, Min; Gu, Qianqian; Qin, Shucun] Shandong First Med Univ & Shandong Acad Med Sci, Taishan Inst Hydrogen Biomed, Tai An 271000, Shandong, Peoples R China.
   [Liu, Boyan; Xue, Junli; Zhang, Mengyu; Wang, Mingyue; Ma, Tingting; Zhao, Min; Gu, Qianqian; Qin, Shucun] Shandong First Med Univ & Shandong Acad Med Sci, Inst Atherosclerosis, Key Lab Atherosclerosis Univ Shandong Prov, 2 Yingsheng East Rd, Tai An 271000, Shandong, Peoples R China.
C3 Shandong First Medical University & Shandong Academy of Medical
   Sciences; Shandong First Medical University & Shandong Academy of
   Medical Sciences
RP Qin, SC (corresponding author), Shandong First Med Univ & Shandong Acad Med Sci, Inst Atherosclerosis, Key Lab Atherosclerosis Univ Shandong Prov, 2 Yingsheng East Rd, Tai An 271000, Shandong, Peoples R China.
EM scqin@sdfmu.edu.cn
RI Wang, Ming-Yue/GSD-5460-2022; XUE, JUNLI/ABE-8689-2021
FU National Natural Science Foundation of China [81770855]; Taishan
   Scholars Program of Shandong Province [ts201511057]; Academic promotion
   programme of Shandong First Medical University [2019QL010, 2019PT009]
FX The present study was supported by the National Natural Science
   Foundation of China (grant no. 81770855), Taishan Scholars Program of
   Shandong Province (grant no. ts201511057) and the Academic promotion
   programme of Shandong First Medical University (grant nos. 2019QL010 and
   2019PT009).
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NR 57
TC 20
Z9 20
U1 1
U2 18
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1791-2997
EI 1791-3004
J9 MOL MED REP
JI Mol. Med. Rep.
PD OCT
PY 2020
VL 22
IS 4
BP 2860
EP 2868
DI 10.3892/mmr.2020.11364
PG 9
WC Oncology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Research & Experimental Medicine
GA NW4US
UT WOS:000575004300029
PM 32945408
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Lian, Y
   Yuan, Q
   Wang, GP
   Tang, F
AF Lian Ying
   Yuan Qun
   Wang Gangpu
   Tang Fang
TI Association between sleep quality and metabolic syndrome: A systematic
   review and meta-analysis
SO PSYCHIATRY RESEARCH
LA English
DT Review
DE Sleep quality; Metabolic syndrome; Meta-analysis
ID INSOMNIA SYMPTOMS; OXIDATIVE STRESS; UNITED-STATES; DURATION;
   POPULATION; INFLAMMATION; DISEASES; HEALTH; COHORT; DISTURBANCE
AB Sleep quality has been suggested to play an important role in development of metabolic syndrome (MetS). However, the results have been inconsistent. A systematic review of observational studies aimed to evaluate the association between sleep quality and MetS. A comprehensive search was conducted in PubMed and EMBASE. The pooled odd ratios (ORs) were calculated using random effects models. The construction of funnel plot was used to explore publication bias, with further application of Egger's test. 22 studies were included. The pooled finding showed that overall sleep quality had a significant positive association with MetS (OR 1.37, 95% CI 1.15-1.64), with substantial heterogeneity (I-2 = 62.4%, P < 0.1). Similarly, the complaints of sleep, including difficulty in falling sleep (OR 1.18, 95% CI 1.05-1.33), difficulty in maintaining sleep (OR 1.15, 95% CI 1.02-1.30) and sleep inefficiency (OR 1.40, 95% CI 1.04-1.89) were proved to be associated with the risk of MetS. Our results indicated the overall sleep quality as well as sleep complaints have significant positive associations with MetS. Further studies based on a longitudinal design using validated tools that measure both objective and subjective components of sleep quality are needed to explore the causal relationship between sleep quality and MetS.
C1 [Lian Ying] Shandong Univ, Dept Med Record Management, Qianfoshan Hosp, Jinan, Shandong, Peoples R China.
   [Yuan Qun] Shandong Ctr Dis Control & Prevent, Jinan, Shandong, Peoples R China.
   [Wang Gangpu] Fourth Hosp Jinan City, Dept Gen Surg, Jinan, Shandong, Peoples R China.
   [Tang Fang] Shandong Univ, Ctr Data Sci Hlth & Med, Qianfoshan Hosp, Jinan, Shandong, Peoples R China.
C3 Shandong University; Shandong First Medical University & Shandong
   Academy of Medical Sciences; Shandong First Medical University &
   Shandong Academy of Medical Sciences; Shandong University
RP Tang, F (corresponding author), Shandong Univ, Ctr Data Sci Hlth & Med, Qianfoshan Hosp, Jinan, Shandong, Peoples R China.
EM tangfangsdu@gmail.com
FU Shandong Provincial Key Research and Development Program
   [2016GSF201075]; Shandong Provincial Natural Science Foundation
   [ZR2015HL102]; Shandong Provincial Medical and Health Science and
   Technology Development Project [2016WS0478]
FX This study was supported by Shandong Provincial Key Research and
   Development Program (Grant No. 2016GSF201075), Shandong Provincial
   Natural Science Foundation (Grant No. ZR2015HL102), and Shandong
   Provincial Medical and Health Science and Technology Development Project
   (Grant No. 2016WS0478).
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NR 64
TC 85
Z9 91
U1 1
U2 23
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0165-1781
EI 1872-7123
J9 PSYCHIAT RES
JI Psychiatry Res.
PD APR
PY 2019
VL 274
BP 66
EP 74
DI 10.1016/j.psychres.2019.01.096
PG 9
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA HU1VG
UT WOS:000465059300011
PM 30780064
DA 2025-06-11
ER

PT J
AU Gan, YL
   Fu, JY
   Lai, OM
   Chew, BH
   Yuen, KH
   Teng, KT
   Nesaretnam, K
   Selvaduray, KR
   Meganathan, P
AF Gan, Yee-Lin
   Fu, Ju-Yen
   Lai, Oi-Ming
   Chew, Boon-How
   Yuen, Kah-Hay
   Teng, Kim-Tiu
   Nesaretnam, Kalanithi
   Selvaduray, Kanga Rani
   Meganathan, Puvaneswari
TI Effect of palm-based tocotrienols and tocopherol mixture supplementation
   on platelet aggregation in subjects with metabolic syndrome: a
   randomised controlled trial
SO SCIENTIFIC REPORTS
LA English
DT Article
ID VITAMIN-E SUPPLEMENTATION; ALPHA-TOCOPHEROL; DIABETIC-PATIENTS;
   CHOLESTEROL; MECHANISMS; PARAMETERS; ADHESION; THERAPY; STRESS; HUMANS
AB Tocotrienols, the unsaturated form of vitamin E, were reported to modulate platelet aggregation and thrombotic mechanisms in pre-clinical studies. Using a Food and Drug Administration (FDA)-approved cartridge-based measurement system, a randomised, double-blind, crossover and placebo-controlled trial involving 32 metabolic syndrome adults was conducted to investigate the effect of palm-based tocotrienols and tocopherol (PTT) mixture supplementation on platelet aggregation reactivity. The participants were supplemented with 200 mg (69% tocotrienols and 31% alpha-tocopherol) twice daily of PTT mixture or placebo capsules for 14 days in a random order. After 14 days, each intervention was accompanied by a postprandial study, in which participants consumed 200 mg PTT mixture or placebo capsule after a meal. Blood samples were collected on day 0, day 14 and during postprandial for the measurement of platelet aggregation reactivity. Subjects went through a 15-day washout period before commencement of subsequent intervention. Fasting platelet aggregation reactivity stimulated with adenosine diphosphate (ADP) did not show substantial changes after supplementation with PTT mixture compared to placebo (p = 0.393). Concomitantly, changes in postprandial platelet aggregation reactivity remained similar between PTT mixture and placebo interventions (p = 0.408). The results of this study highlight the lack of inhibitory effect on platelet aggregation after short-term supplementation of PTT mixture in participants with metabolic syndrome.
C1 [Gan, Yee-Lin; Lai, Oi-Ming] Univ Putra Malaysia, Dept Bioproc Technol, Fac Biotechnol & Biomol Sci, Serdang, Malaysia.
   [Gan, Yee-Lin; Fu, Ju-Yen; Teng, Kim-Tiu; Nesaretnam, Kalanithi; Selvaduray, Kanga Rani; Meganathan, Puvaneswari] Persiaran Inst, Nutr Unit, Prod Dev & Advisory Serv Div, Malaysian Palm Oil Board, 6 Bandar Baru Bangi, Kajang, Selangor, Malaysia.
   [Lai, Oi-Ming] Univ Putra Malaysia, Inst Biosci, Serdang, Malaysia.
   [Chew, Boon-How] Univ Putra Malaysia, Dept Family Med, Fac Med & Hlth Sci, Serdang, Malaysia.
   [Yuen, Kah-Hay] Univ Sains Malaysia, Sch Pharmaceut Sci, George Town, Malaysia.
C3 Universiti Putra Malaysia; Malaysian Palm Oil Board; Universiti Putra
   Malaysia; Universiti Putra Malaysia; Universiti Sains Malaysia
RP Fu, JY (corresponding author), Persiaran Inst, Nutr Unit, Prod Dev & Advisory Serv Div, Malaysian Palm Oil Board, 6 Bandar Baru Bangi, Kajang, Selangor, Malaysia.
EM fujuyen@gmail.com
RI Fu, Ju/AAX-4041-2020; Yuen, Kah/F-9059-2010; Chew, Boon How/B-2385-2010
OI Kim Tiu, Teng/0000-0003-1383-8913; Fu, Ju-Yen/0000-0002-4398-4471;
   Selvaduray, Kanga Rani/0000-0003-1832-3118; Chew, Boon
   How/0000-0002-8627-6248
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NR 55
TC 7
Z9 7
U1 0
U2 8
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD SEP 14
PY 2017
VL 7
AR 11542
DI 10.1038/s41598-017-11813-w
PG 10
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA FG9DM
UT WOS:000410739000040
PM 28912593
OA Green Accepted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Semenova, N
   Garashchenko, N
   Kolesnikov, S
   Darenskaya, M
   Kolesnikova, L
AF Semenova, Natalya
   Garashchenko, Nadezhda
   Kolesnikov, Sergey
   Darenskaya, Marina
   Kolesnikova, Liubov
TI Gut Microbiome Interactions with Oxidative Stress: Mechanisms and
   Consequences for Health
SO PATHOPHYSIOLOGY
LA English
DT Review
DE gut microbiome; oxidative stress; food supplements; TMAO; melatonin;
   mitochondria
ID INFLAMMATORY-BOWEL-DISEASE; ADOLESCENTS; DEFINITION; AUTOPHAGY; SYSTEM;
   DAMAGE
AB Understanding how gut flora interacts with oxidative stress has been the subject of significant research in recent years. There is much evidence demonstrating the existence of the microbiome-oxidative stress interaction. However, the biochemical basis of this interaction is still unclear. In this narrative review, possible pathways of the gut microbiota and oxidative stress interaction are presented, among which genetic underpinnings play an important role. Trimethylamine-N-oxide, mitochondria, short-chain fatty acids, and melatonin also appear to play roles. Moreover, the relationship between oxidative stress and the gut microbiome in obesity, metabolic syndrome, chronic ethanol consumption, dietary supplements, and medications is considered. An investigation of the correlation between bacterial community features and OS parameter changes under normal and pathological conditions might provide information for the determination of new research methods. Furthermore, such research could contribute to establishing a foundation for determining the linkers in the microbiome-OS association.
C1 [Semenova, Natalya; Garashchenko, Nadezhda; Kolesnikov, Sergey; Darenskaya, Marina; Kolesnikova, Liubov] Sci Ctr Family Hlth & Human Reprod Problems, Irkutsk 664003, Russia.
C3 Irkutsk Science Centre of the Russian Academy of Sciences; Scientific
   Centre for Family Health & Human Reproduction Problems
RP Semenova, N (corresponding author), Sci Ctr Family Hlth & Human Reprod Problems, Irkutsk 664003, Russia.
EM natkor_84@mail.ru; nadzelin@mail.ru; sikolesnikov2012@gmail.com;
   marina_darenskaya@inbox.ru; kolesnikova20121@mail.ru
RI Semenova, Natalya/J-7025-2016; Darenskaya, Marina A./O-4490-2015;
   Kolesnikov, Sergey/M-4020-2016
OI Darenskaya, Marina A./0000-0003-3255-2013; Semenova,
   Natalya/0000-0002-6512-1335; Kolesnikov, Sergey/0000-0003-2124-6328
FX This research received no external funding.
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NR 103
TC 7
Z9 7
U1 2
U2 4
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 0928-4680
EI 1873-149X
J9 PATHOPHYSIOLOGY-BASE
JI Pathophysiology
PD SEP
PY 2024
VL 31
IS 3
BP 309
EP 330
DI 10.3390/pathophysiology31030023
PG 22
WC Pathology
WE Emerging Sources Citation Index (ESCI)
SC Pathology
GA H4O4X
UT WOS:001323250000001
PM 39051221
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Wang, MJ
   Liu, JL
   Zhang, Z
   Zhang, HX
   Wang, N
   Chen, X
   Han, XM
   Lu, Q
   Chi, SS
AF Wang, Mengjun
   Liu, Junliang
   Zhang, Zhao
   Zhang, Haixiong
   Wang, Ning
   Chen, Xi
   Han, Xuemei
   Lu, Qian
   Chi, Shanshan
TI Effects of Dietary Intervention on Inflammatory Markers in Metabolic
   Syndrome: A Systematic Review and Meta-Analysis
SO FRONTIERS IN NUTRITION
LA English
DT Review
DE diets; inflammatory markers; IL-6; metabolic syndrome; meta-analysis
ID ENDOTHELIAL FUNCTION; OXIDATIVE STRESS; HEART-DISEASE; CEREAL FOODS;
   RISK-FACTORS; OBESITY; ADULTS; INTERLEUKIN-6; CARBOHYDRATE; RESTRICTION
AB BackgroundDietary interventions may modulate inflammatory indicators, but the correlations between dietary intervention and inflammatory markers in metabolic syndrome (MetS) settings remain opaque. ObjectiveTo evaluate the effects of dietary intervention on interleukin-1 beta (IL-1 beta), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), and C-reactive protein (CRP) in patients with MetS by systematic review and meta-analysis. MethodsDatabases, including PubMed, Embase, Cochrane Library, Scopus, and Google scholar, were searched from June 2011 to June 2021 for relevant available articles. Standardized mean difference (SMD) was generated as effect size by meta-analysis for continuous variants, including IL-1 beta, IL-6, TNF-alpha, and CRP levels. Then, according to study characteristics by dietary patterns of the intervention, subgroup analyses were performed. ResultsFinally, 13 studies comprising a total of 1,101 participants were included for the meta-analysis. IL-6 levels in dietary patients were significantly lower than controls (SMD = -0.30, 95% CI = -0.55, 0.04, p = 0.02, I-2 = 64%). However, IL-1 beta, TNF-alpha, and CRP levels did not change significantly compared with the control group. Sensitivity analyses further yielded similar results. ConclusionsDietary intervention may help decrease IL-6 rather than IL-1 beta, TNF-alpha, or CRP levels in patients with MetS.
C1 [Wang, Mengjun; Wang, Ning] Xi An Jiao Tong Univ, Affiliated Hosp 1, Dept Endocrinol, Xian, Peoples R China.
   [Liu, Junliang; Zhang, Zhao; Zhang, Haixiong; Han, Xuemei; Lu, Qian; Chi, Shanshan] 521 Hosp Norinco Grp, Dept Endocrinol, Xian, Peoples R China.
   [Chen, Xi] Zhejiang Univ, Med Coll, Sch Publ Hlth, Dept Epidemiol & Stat, Hangzhou, Peoples R China.
C3 Xi'an Jiaotong University; Zhejiang University
RP Zhang, Z (corresponding author), 521 Hosp Norinco Grp, Dept Endocrinol, Xian, Peoples R China.
EM wmj19871112521@163.com
RI Han, Xuemei/JGE-2116-2023; zhao, sheng/JWO-6127-2024; Wang,
   Ning/AFI-3287-2022
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NR 41
TC 9
Z9 9
U1 0
U2 9
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD MAR 31
PY 2022
VL 9
AR 846591
DI 10.3389/fnut.2022.846591
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 0V8GV
UT WOS:000788578900001
PM 35433780
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Mastrodonato, M
   Calamita, G
   Rossi, R
   Mentino, D
   Bonfrate, L
   Portincasa, P
   Ferri, D
   Liquori, GE
AF Mastrodonato, Maria
   Calamita, Giuseppe
   Rossi, Roberta
   Mentino, Donatella
   Bonfrate, Leonilde
   Portincasa, Piero
   Ferri, Domenico
   Liquori, Giuseppa E.
TI Altered distribution of caveolin-1 in early liver steatosis
SO EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
LA English
DT Article
DE Choline-deficient diet; fatty liver; immunoblotting;
   immunohistochemistry; metabolic syndrome
ID NONALCOHOLIC-FATTY-LIVER; CHOLINE-DEFICIENT DIET; METABOLIC SYNDROME;
   OXIDATIVE STRESS; INSULIN-RESISTANCE; PLASMA-MEMBRANE; LIPID DROPLETS;
   MITOCHONDRIAL DYSFUNCTION; EXTRAHEPATIC CHOLESTASIS;
   ENDOPLASMIC-RETICULUM
AB P>Background
   Caveolin-1, the main structural protein of caveolae, is involved in cholesterol homoeostasis, transcytosis, endocytosis and signal transduction and thought to play an important role in lipidogenesis. Little is known about the pathophysiological role of caveolin-1 in nonalcoholic fatty liver disease (NAFLD), a condition frequently associated with the metabolic syndrome and characterized by abnormal accumulation of intrahepatic triglycerides with a potentially harmful risk of evolution to liver fibrosis, cirrhosis and hepatocellular carcinoma.
   Materials and methods
   Liver steatosis (micro/macrovesicular) was induced in adult rats fed a choline-deficient diet for 14 days and compared with a control normal diet. The expression and subcellular distribution of caveolin-1 was assessed using light and electron microscopy by immunohistochemical and immunocytochemical techniques and by Western blotting.
   Results
   Caveolin-1 was mainly associated with the hepatocyte basolateral plasma membrane. Fatty hepatocytes were characterized by a significant increase in the expression of caveolin-1 around and within the lipid droplets as well as in the inner membrane of mitochondria.
   Conclusions
   Our data suggest the involvement of caveolin-1 in the case of abnormal lipogenesis and mitochondrial function typical of steatotic hepatocytes in NAFLD. Addressing the role played by caveolin-1 in liver membranes in NAFLD may help future therapeutic choices in a frequent metabolic liver disease.
C1 [Mastrodonato, Maria; Mentino, Donatella; Ferri, Domenico; Liquori, Giuseppa E.] Aldo Moro Univ, Dept Anim & Environm Biol, Bari, Italy.
   [Calamita, Giuseppe] Aldo Moro Univ, Dept Gen & Environm Physiol, Bari, Italy.
   [Rossi, Roberta] Aldo Moro Univ, Lab Ultrastruct Pathol, Bari, Italy.
   [Bonfrate, Leonilde; Portincasa, Piero] Aldo Moro Univ, Dept Internal Med & Publ Med, Bari, Italy.
C3 Universita degli Studi di Bari Aldo Moro; Universita degli Studi di Bari
   Aldo Moro; Universita degli Studi di Bari Aldo Moro; Universita degli
   Studi di Bari Aldo Moro
RP Mastrodonato, M (corresponding author), Dipartimento Biol Anim & Ambientale, Lab Istol & Anat Comparata, Via Orabona 4, I-70125 Bari, Italy.
EM m.mastrodonato@biologia.uniba.it
RI Bonfrate, Leonilde/ABH-1835-2021; Rossi, Roberta/J-9137-2016;
   portincasa, piero/J-7245-2018; Mastrodonato, Maria/P-4513-2016
OI portincasa, piero/0000-0001-5359-1471; Calamita,
   Giuseppe/0000-0003-4666-9546; Mastrodonato, Maria/0000-0002-0799-8032;
   Mentino, Donatella/0000-0002-0680-5251; ROSSI,
   Roberta/0000-0003-4586-9044
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NR 59
TC 26
Z9 30
U1 0
U2 12
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0014-2972
J9 EUR J CLIN INVEST
JI Eur. J. Clin. Invest.
PD JUN
PY 2011
VL 41
IS 6
BP 642
EP 651
DI 10.1111/j.1365-2362.2010.02459.x
PG 10
WC Medicine, General & Internal; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Research & Experimental Medicine
GA 759FP
UT WOS:000290226400009
PM 21250982
DA 2025-06-11
ER

PT J
AU Murdolo, G
   Bartolini, D
   Tortoioli, C
   Piroddi, M
   Iuliano, L
   Galli, F
AF Murdolo, Giuseppe
   Bartolini, Desiree
   Tortoioli, Cristina
   Piroddi, Marta
   Iuliano, Luigi
   Galli, Francesco
TI Lipokines and oxysterols: Novel adipose-derived lipid hormones linking
   adipose dysfunction and insulin resistance
SO FREE RADICAL BIOLOGY AND MEDICINE
LA English
DT Review
DE Adipose tissue; Insulin resistance; Obesity; Oxidative stress;
   Preadipocytes; Oxysterols; 4-Hydroxynonenal; Free radicals
ID MARROW STROMAL CELLS; OXIDATIVE STRESS; ADIPOCYTE DIFFERENTIATION;
   GENE-EXPRESSION; REACTIVE OXYGEN; METABOLIC SYNDROME; PREADIPOCYTE
   DIFFERENTIATION; CHOLESTEROL OXIDATION; IMPAIRED ADIPOGENESIS;
   HYPERTROPHIC OBESITY
AB The expansion of adipose tissue (AT.) is, by definition, a hallmark of obesity. However, not all increases in fat mass are associated with pathophysiological cues. Indeed, whereas a "healthy" fat mass accrual, mainly in the subcutaneous depots, preserves metabolic homeostasis, explaining the occurrence of the metabolically healthy obese phenotype, "unhealthy" AT expansion is importantly associated with insulin resistance/type 2 diabetes and the metabolic syndrome. The development of a dysfunctional adipose organ may find mechanistic explanation in a reduced ability to recruit new and functional (pre)adipocytes from undifferentiated precursor cells. Such a failure of the adipogenic process underlies the "AT expandability" paradigm. The inability of AT to expand further to store excess nutrients, rather than obesity per se, induces a diabetogenic milieu by promoting the overflow and the ectopic deposition of fatty acids in insulin-dependent organs (i.e., lipotoxicity), the secretion of various metabolically detrimental adipose-derived hormones (i.e., adipoldnes and lipokines), and the occurrence of local and systemic inflammation and oxidative stress. Hitherto, fatty acids (i.e., lipokines) and the oxidation by-products of cholesterol and polyunsaturated fatty acids, such as nonenzymatic oxysterols and reactive aldehyde species, respectively, emerge as key modulators of (pre)adipocyte signaling through Wnt/beta-catenin and MAPK pathways and potential regulators of glucose homeostasis. These and other mechanistic insights linking adipose dysfunction, oxidative stress, and impairment of glucose homeostasis are discussed in this review article, which focuses on adipose peroxidation as a potential instigator of, and a putative therapeutic target for, obesity-associated metabolic dysfunctions. (C) 2013 Elsevier Inc. All rights reserved.
C1 [Murdolo, Giuseppe] Assisi Hosp, Dept Internal Med, I-06081 Perugia, Italy.
   [Bartolini, Desiree; Piroddi, Marta; Galli, Francesco] Univ Perugia, Dept Internal Med, Sect Appl Biochem & Nutr Sci, I-06100 Perugia, Italy.
   [Iuliano, Luigi] Univ Roma La Sapienza, Dept Med Surg Sci & Biotechnol, Unit Vasc Med, Latina, Italy.
C3 University of Perugia; University of Perugia; Sapienza University Rome
RP Murdolo, G (corresponding author), Assisi Hosp, Dept Internal Med, I-06081 Perugia, Italy.
EM gmurdolo@tiscali.it
RI Murdolo, Giuseppe/I-1812-2012; Iuliano, Luigi/A-5266-2008; Galli,
   Francesco/K-5048-2016; Bartolini, Desiree/K-5319-2016; Piroddi,
   Marta/K-5302-2016
OI Iuliano, Luigi/0000-0002-0027-9326; Galli,
   Francesco/0000-0003-3626-051X; Bartolini, Desiree/0000-0003-3849-757X;
   Piroddi, Marta/0000-0002-0880-0630; Murdolo,
   Giuseppe/0000-0001-5654-1760
FU Fondazione Cassa di Risparmio di Perugia (Project "Ricerca Scientifica e
   Tecnologica") [2010.020.0098]
FX This work was partly funded by a grant from the Fondazione Cassa di
   Risparmio di Perugia (Project 2010.020.0098 "Ricerca Scientifica e
   Tecnologica"). The authors acknowledge Mrs. Chiara Baccellini and Mrs.
   Martina Spinsanti for their valuable collaboration.
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NR 137
TC 45
Z9 48
U1 0
U2 30
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0891-5849
EI 1873-4596
J9 FREE RADICAL BIO MED
JI Free Radic. Biol. Med.
PD DEC
PY 2013
VL 65
BP 811
EP 820
DI 10.1016/j.freeradbiomed.2013.08.007
PG 10
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 278DI
UT WOS:000328868900076
PM 23954331
DA 2025-06-11
ER

PT J
AU Chen, TH
   Kung, WS
   Sun, HY
   Huang, JJ
   Lu, JY
   Luo, KH
   Chuang, HY
AF Chen, Tzu-Hua
   Kung, Wei-Shyang
   Sun, Hung-Yu
   Huang, Joh-Jong
   Lu, Jia-Yi
   Luo, Kuei-Hau
   Chuang, Hung-Yi
TI The Relationship between Metabolic Syndrome and Plasma Metals Modified
   by EGFR and TNF-α Gene Polymorphisms
SO TOXICS
LA English
DT Article
DE metabolic disorders; metabolic syndrome; epidermal growth factor
   receptor (EGFR); TNF-alpha; single nucleotide polymorphism (SNP);
   metals; inflammation; insulin resistance; Taiwan biobank
ID OXIDATIVE STRESS; HEAVY-METALS; ASSOCIATION; RECEPTOR; HYPERTENSION;
   PREVALENCE; PROTEIN; HEALTH; RISK
AB With the escalating global prevalence of metabolic syndrome (MetS), it is crucial to detect the high-risk population early and to prevent chronic diseases. Exposure to various metals has been indicated to promote MetS, but the findings were controversial, and the effect of genetic modification was not considered. Epidermal growth factor receptor (EGFR) was proposed to be involved in the pathway of metabolic disorders, and tumor necrotic factor-alpha (TNF-alpha) was regarded as an early inflammatory biomarker for MetS. This research aimed to analyze the impact of EGFR and TNF-alpha gene polymorphisms on the prevalence of MetS under environmental or occupational exposure to metals. We gathered data from 376 metal industrial workers and 639 non-metal workers, including physical parameters, biochemical data, and plasma concentrations of six metals. According to the genomic database of Taiwan Biobank, 23 single nucleotide polymorphisms (SNPs) on EGFR gene and 6 SNPs on TNF-alpha gene were incorporated in our research. We applied multivariable logistic regression to analyze the probability of MetS with various SNPs and metals. Our study revealed some susceptible and protective EGFR and TNF-alpha genotypes under excessive exposure to cobalt, zinc, selenium, and lead. Thus, we remind the high-risk population of taking measures to prevent MetS.
C1 [Chen, Tzu-Hua; Lu, Jia-Yi; Chuang, Hung-Yi] Kaohsiung Med Univ, Coll Hlth Sci, Dept Publ Hlth, Kaohsiung 80708, Taiwan.
   [Chen, Tzu-Hua] Kaohsiung Municipal Tatung Hosp, Dept Family Med, Kaohsiung 80145, Taiwan.
   [Chen, Tzu-Hua; Huang, Joh-Jong] Kaohsiung Med Univ Hosp, Dept Family Med, Kaohsiung 80708, Taiwan.
   [Kung, Wei-Shyang] Chien Shin Hosp, Dept Pediat, Kaohsiung 80143, Taiwan.
   [Sun, Hung-Yu] Changhua Christian Hosp, Dept Family Med, Changhua 50006, Taiwan.
   [Luo, Kuei-Hau] Kaohsiung Med Univ, Coll Med, Grad Inst Med, Kaohsiung 80708, Taiwan.
   [Chuang, Hung-Yi] Kaohsiung Med Univ Hosp, Dept Environm & Occupat Med, Kaohsiung 80708, Taiwan.
   [Chuang, Hung-Yi] Kaohsiung Med Univ, Coll Med, Res Ctr Environm Med, PhD Program Environm & Occupat Med, Kaohsiung 80708, Taiwan.
C3 Kaohsiung Medical University; Kaohsiung Medical University; Kaohsiung
   Municipal Ta-Tung Hospital; Kaohsiung Medical University; Kaohsiung
   Medical University Hospital; Changhua Christian Hospital; Kaohsiung
   Medical University; Kaohsiung Medical University; Kaohsiung Medical
   University Hospital; Kaohsiung Medical University
RP Chuang, HY (corresponding author), Kaohsiung Med Univ, Coll Hlth Sci, Dept Publ Hlth, Kaohsiung 80708, Taiwan.; Chuang, HY (corresponding author), Kaohsiung Med Univ Hosp, Dept Environm & Occupat Med, Kaohsiung 80708, Taiwan.; Chuang, HY (corresponding author), Kaohsiung Med Univ, Coll Med, Res Ctr Environm Med, PhD Program Environm & Occupat Med, Kaohsiung 80708, Taiwan.
EM 980264@kmuh.org.tw; u104862002@kmu.edu.tw; 144107@cch.org.tw;
   1030578@kmuh.org.tw; u105570008@kmu.edu.tw; u107800007@kmu.edu.tw;
   ericch@kmu.edu.tw
RI Chuang, Hung-Yi/C-9143-2009; Lu, Jiayi/IQS-9529-2023
FU Ministry of Science and Technology of Taiwan [MOST 109-2911-I-037-501];
   Kaohsiung Medical University Hospital [KMUH1099T05]; Kaohsiung Medical
   University [KMU-TC109A01-1]; Kaohsiung Municipal Ta-Tung Hospital
   [kmtth-109-003]
FX This research was funded by the Ministry of Science and Technology of
   Taiwan (Grant number: MOST 109-2911-I-037-501) and grants from Kaohsiung
   Medical University Hospital (KMUH1099T05), Kaohsiung Medical University
   (KMU-TC109A01-1) and Kaohsiung Municipal Ta-Tung Hospital
   (kmtth-109-003).
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NR 53
TC 2
Z9 2
U1 0
U2 6
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2305-6304
J9 TOXICS
JI Toxics
PD SEP
PY 2021
VL 9
IS 9
AR 225
DI 10.3390/toxics9090225
PG 13
WC Environmental Sciences; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Toxicology
GA UX8CG
UT WOS:000701065900001
PM 34564376
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Kim, CH
   Noh, IK
   Ryu, JM
   Bae, EJ
   Cho, HJ
   Kim, MS
AF Kim, Chul-Hoon
   Noh, In-Kyoung
   Ryu, Jung Mi
   Bae, Eun Jung
   Cho, Hoo Jeung
   Kim, Myoung Soo
TI Canonical Correlation between Behavioral-Psychological Variables and
   Predictors of Coronary Artery Disease Prognosis
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Article
DE coronary artery disease; lifestyle; metabolic syndrome; severity of
   illness index; type-D personality
ID D PERSONALITY; METABOLIC SYNDROME; NEGATIVE AFFECTIVITY; SOCIAL
   INHIBITION; HEART-DISEASE; RISK-FACTORS; FOLLOW-UP; PREVALENCE;
   SEVERITY; CONSEQUENCES
AB Metabolic syndrome (MetS) and severity of coronary artery disease (CAD) are considered predictors of CAD prognosis. Unhealthy lifestyles and type-D personality are associated with MetS and are potential causes of primary and secondary CAD. In this cross-sectional descriptive study, we aimed to investigate the relationship between behavioral-psychological variables and predictors of CAD prognosis. The behavioral-psychological variable set contained six lifestyle categories and two type-D personality categories. Descriptive analyses, t-tests, analysis of variance, Pearson's correlation, and canonical correlation were used. The behavioral-psychological variable set was related to the predictor set for CAD prognosis, with a significant canonical variate of 0.67 (45% overlapping variance). Significant pairs of canonical variates indicated that poor physical activity and weight control (-0.77), poor dietary habits (-0.78), alcohol consumption and cigarette smoking (-0.37), lack of sleep and rest (-0.40), stress (-0.64) in the lifestyle set, higher negative affectivity (0.52), and social inhibition (0.71) in the type-D personality set were associated with a high MetS score (0.59) and severity of CAD (0.91). A combination of behavioral and psychological variables was found to be important in predicting the prognosis of CAD; therefore, interventions aimed at preventing combinations of these variables may be effective in improving CAD prognosis.
C1 [Kim, Chul-Hoon] Dong A Univ, Coll Med, Busan 49201, South Korea.
   [Noh, In-Kyoung] Kosin Univ, Dept Internal Med, Gospel Hosp, Busan 49267, South Korea.
   [Ryu, Jung Mi; Bae, Eun Jung; Cho, Hoo Jeung; Kim, Myoung Soo] Pukyong Natl Univ, Dept Nursing, Busan 48513, South Korea.
   [Bae, Eun Jung] Dongnam Inst Radiol & Med Sci, Dept Nursing, Busan 46033, South Korea.
C3 Dong A University; Pukyong National University; Korea Institute of
   Radiological & Medical Sciences
RP Kim, MS (corresponding author), Pukyong Natl Univ, Dept Nursing, Busan 48513, South Korea.
EM bbp2000@hanmail.net; ada10kr@naver.com; rewmis@naver.com;
   beaulife-@hanmail.net; ccu0401@naver.com; kanosa@pknu.ac.kr
RI Kim, Young/T-8521-2019; Kim, Chang/H-4759-2011
OI Kim, Myoung Soo/0000-0002-1773-1374
FU Dong-A University research fund
FX This work was supported by the Dong-A University research fund.
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NR 57
TC 6
Z9 7
U1 0
U2 6
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD MAR
PY 2020
VL 17
IS 5
AR 1608
DI 10.3390/ijerph17051608
PG 14
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA KY2GJ
UT WOS:000522389200148
PM 32131511
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Al Sharif, M
   Vitcheva, V
   Simeonova, R
   Krasteva, I
   Manov, V
   Alov, P
   Popov, G
   Shkondrov, A
   Pajeva, I
AF Al Sharif, Merilin
   Vitcheva, Vessela
   Simeonova, Rumyana
   Krasteva, Ilina
   Manov, Vasil
   Alov, Petko
   Popov, Georgi
   Shkondrov, Aleksandar
   Pajeva, Ilza
TI In silico and in vivo studies of Astragalus
   glycyphylloides saponin(s) with relevance to metabolic syndrome
   modulation
SO FOOD AND CHEMICAL TOXICOLOGY
LA English
DT Article; Proceedings Paper
CT 1st International Conference on Natural Toxicology and Pharmacology
   (ICNTP)
CY AUG 08-12, 2019
CL Guangzhou, PEOPLES R CHINA
SP Jinan Univ, Zhejiang Univ, Univ Macau, Univ Hong Kong, Int Assoc Dietet Nutr & Safety, Int Soc Chinese Med
DE Metabolic syndrome; Saponins; Metabolites; PPAR gamma;
   Pharmacophore-based docking; Diabetic spontaneously hypertensive rats
ID TRITERPENE SAPONINS; OLEANOLIC ACID; RAT; TOXICITY; PIOGLITAZONE;
   HYPERTENSION; AGONIST; TOOLS
AB Triterpenoids are well known modulators of metabolic syndrome. One of the suggested modes of action (MoAs) involves peroxisome proliferator-activated receptor gamma (PPAR gamma) binding.
   In this study we aimed to: (i) evaluate in silica potential metabolites and PPAR gamma-mediated MoA of the sapogenin of the main saponin present in a purified saponins' mixture (PSM) from Astragalus glycyphylloides; (ii) estimate in silica and in vivo PSM's toxicity; and (iii) investigate in vivo antihyperglycaemic, hypolipidaemic, antioxidant and hepatoprotective effects of PSM.
   Metabolites and toxicity were predicted using Meteor and Derek Nexus expert systems (Lhasa Limited) and PPAR gamma binding was investigated using the software MOE (CCG Inc.). PSM's acute oral toxicity was evaluated in mice and the pharmacological effects were assessed in streptozotocin-induced diabetic spontaneously hypertensive rats (SHRs). Liver histopathology was studied as well.
   PPAR gamma weak partial agonism was predicted in silico for 24 probable/plausible Phase I metabolites which docking poses were clustered in 12 different binding modes with characteristic protein-ligand interactions. PSM's beneficial effects on the levels of blood glucose, triglycerides, and total cholesterol, on oxidative stress markers and liver histology in diabetic SHRs were comparable to those of the PPAR gamma ligand pioglitazone. PSM's safety profile was confirmed in silico and in vivo.
C1 [Al Sharif, Merilin; Alov, Petko; Pajeva, Ilza] Bulgarian Acad Sci, Inst Biophys & Biomed Engn, Dept QSAR & Mol Modelling, Acad G Bonchev Str,Bl 105, BU-1113 Sofia, Bulgaria.
   [Vitcheva, Vessela; Simeonova, Rumyana] Med Univ Sofia, Fac Pharm, Dept Pharmacol Pharmacotherapy & Toxicol, Dunav 2 Str, Sofia 1000, Bulgaria.
   [Krasteva, Ilina; Shkondrov, Aleksandar] Med Univ Sofia, Fac Pharm, Dept Pharmacognosy, Dunav 2 Str, Sofia 1000, Bulgaria.
   [Manov, Vasil; Popov, Georgi] Univ Forestry Sofia, Fac Vet Med, Dept Internal Noncommunicable Dis Pathol & Pharma, 10 Kliment Ochridsky Blvd, Sofia 1756, Bulgaria.
C3 Bulgarian Academy of Sciences; Medical University Sofia; Medical
   University Sofia; University of Forestry - Bulgaria
RP Al Sharif, M (corresponding author), Bulgarian Acad Sci, Inst Biophys & Biomed Engn, Dept QSAR & Mol Modelling, Acad G Bonchev Str,Bl 105, BU-1113 Sofia, Bulgaria.
EM merilin.al@biomed.bas.bg; vesselavitcheva@yahoo.com;
   rvitanska@gmail.com; krasteva.ilina@abv.bg; vmanov@ltu.bg;
   petko@biophys.bas.bg; gpopov@ltu.bg; a_shkondrov@abv.bg;
   pajeva@biomed.bas.bg
RI Pajeva, Ilza/J-3242-2012; Popov, Georgi/LVR-9589-2024; Krasteva,
   Ilina/AFI-7757-2022; Simeonova, Rumyana/G-8002-2019; Shkondrov,
   Aleksandar/AER-5726-2022
OI Alov, Petko/0000-0003-1320-2173; Simeonova, Rumyana/0000-0003-4860-9053;
   Krasteva, Ilina/0000-0001-8559-0369; Shkondrov,
   Aleksandar/0000-0001-5091-6058
FU Bulgarian Ministry of Education and Science under the National Research
   Programme [577/17.08.2018]; National Science Fund of Bulgaria [DM
   01/1/2016]
FX Studies on prediction of Phase I metabolism and toxicity were supported
   by the Bulgarian Ministry of Education and Science under the National
   Research Programme "Healthy Foods for a Strong Bio-Economy and Quality
   of Life" approved by DCM # 577/17.08.2018; the molecular docking
   studies, part of the in vivo experiments and the pathohistological
   analysis were supported by the National Science Fund of Bulgaria (grant
   DM 01/1/2016).
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NR 44
TC 1
Z9 1
U1 0
U2 18
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0278-6915
EI 1873-6351
J9 FOOD CHEM TOXICOL
JI Food Chem. Toxicol.
PD AUG
PY 2019
VL 130
BP 317
EP 325
DI 10.1016/j.fct.2019.05.032
PG 9
WC Food Science & Technology; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Food Science & Technology; Toxicology
GA IE7XV
UT WOS:000472589200030
PM 31128217
DA 2025-06-11
ER

PT J
AU Almomen, SMK
   Guan, QN
   Liang, PH
   Yang, KD
   Sidiqi, AM
   Levin, A
   Du, CG
AF Almomen, Salwa M. K.
   Guan, Qiunong
   Liang, Peihe
   Yang, Kaidi
   Sidiqi, Ahmad M.
   Levin, Adeera
   Du, Caigan
TI Daily Intake of Grape Powder Prevents the Progression of Kidney Disease
   in Obese Type 2 Diabetic ZSF1 Rats
SO NUTRIENTS
LA English
DT Article
DE metabolic syndrome; chronic kidney disease; grape powder; antioxidants;
   natural products; dietary supplements
ID LOW-PROTEIN DIET; OXIDATIVE STRESS; METABOLIC SYNDROME;
   HYDROGEN-PEROXIDE; RENAL-FUNCTION; SKIN EXTRACT; SEED; MECHANISMS;
   HEALTH; NEPHROPATHY
AB Individuals living with metabolic syndrome (MetS) such as diabetes and obesity are at high risk for developing chronic kidney disease (CKD). This study investigated the beneficial effect of whole grape powder (WGP) diet on MetS-associated CKD. Obese diabetic ZSF1 rats, a kidney disease model with MetS, were fed WGP (5%, w/w) diet for six months. Kidney disease was determined using blood and urine chemical analyses, and histology. When compared to Vehicle controls, WGP intake did not change the rat bodyweight, but lowered their kidney, liver and spleen weight, which were in parallel with the lower serum glucose and the higher albumin or albumin/globin ratio. More importantly, WGP intake improved the renal function as urination and proteinuria decreased, or it prevented kidney tissue damage in these diabetic rats. The renal protection of WGP diet was associated with up-regulation of antioxidants (Dhcr24, Gstk1, Prdx2, Sod2, Gpx1 and Gpx4) and downregulation of Txnip (for ROS production) in the kidneys. Furthermore, addition of grape extract reduced H2O2-induced cell death of cultured podocytes. In conclusion, daily intake of WGP reduces the progression of kidney disease in obese diabetic rats, suggesting a protective function of antioxidant-rich grape diet against CKD in the setting of MetS.
C1 [Almomen, Salwa M. K.; Guan, Qiunong; Liang, Peihe; Yang, Kaidi; Sidiqi, Ahmad M.; Du, Caigan] Univ British Columbia, Dept Urol Sci, Vancouver, BC V6H 3Z6, Canada.
   [Guan, Qiunong; Du, Caigan] Vancouver Coastal Hlth Res Inst, Immun & Infect Res Ctr, Vancouver, BC V6H 3Z6, Canada.
   [Liang, Peihe] Chongqing Med Univ, Affiliated Hosp 2, Dept Urol, Chongqing 400010, Peoples R China.
   [Sidiqi, Ahmad M.; Levin, Adeera] Univ British Columbia, Div Nephrol, Dept Med, Vancouver, BC V6Z 1Y6, Canada.
C3 University of British Columbia; Vancouver Coastal Health Research
   Institute; Chongqing Medical University; University of British Columbia
RP Du, CG (corresponding author), Univ British Columbia, Dept Urol Sci, Vancouver, BC V6H 3Z6, Canada.; Du, CG (corresponding author), Vancouver Coastal Hlth Res Inst, Immun & Infect Res Ctr, Vancouver, BC V6H 3Z6, Canada.
EM sa.momen@windowslive.com; qiunong@hotmail.com; lph1972@163.com;
   kaidiyang1994@gmail.com; ahmad.sidiqi@alumni.ubc.ca;
   alevin@providencehealth.bc.ca; caigan@mail.ubc
FU California Table Grape Commission (CA, USA); King Abdullah Scholarship
   Program of the Kingdom of Saudi Arabia; Second Affiliated Hospital of
   Chongqing Medical University; Canadian Mitacs Globalink Internship
FX This study was supported by a grant from the California Table Grape
   Commission (CA, USA); S.M.K.A. received the scholarship from King
   Abdullah Scholarship Program of the Kingdom of Saudi Arabia; P.L. the
   funding support from the Second Affiliated Hospital of Chongqing Medical
   University; and K.Y. the Canadian Mitacs Globalink Internship.
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NR 63
TC 22
Z9 23
U1 0
U2 18
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD APR
PY 2017
VL 9
IS 4
AR 345
DI 10.3390/nu9040345
PG 16
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA EU9JI
UT WOS:000401355600030
PM 28362355
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Pastor, RF
   Repetto, MG
   Lairion, F
   Lazarowski, A
   Merelli, A
   Carabetti, ZM
   Pastor, I
   Pastor, E
   Iermoli, LV
   Bavasso, CA
   Iermoli, RH
AF Pastor, Raul Francisco
   Repetto, Marisa Gabriela
   Lairion, Fabiana
   Lazarowski, Alberto
   Merelli, Amalia
   Manfredi Carabetti, Zulma
   Pastor, Isabel
   Pastor, Elena
   Iermoli, Laura Valeria
   Bavasso, Carlos Amadeo
   Iermoli, Roberto Hector
TI Supplementation with Resveratrol, Piperine and Alpha-Tocopherol
   Decreases Chronic Inflammation in a Cluster of Older Adults with
   Metabolic Syndrome
SO NUTRIENTS
LA English
DT Article
DE metabolic syndrome; chronic inflammation; resveratrol; piperine;
   alpha-tocopherol
ID C-REACTIVE PROTEIN; ADIPOSE-TISSUE; OBESITY; PREVENTION; PREVALENCE
AB Metabolic Syndrome (MetS) is increasing worldwide regardless of culture, genetic, gender, and geographic differences. While multiple individual risk factors, such as obesity, hypertension, diabetes, and hyperlipidemia, can cause cardiovascular disease (CVD), it is the intercurrence of these risk factors that defines MetS as a cluster that creates an environment for atherosclerosis and other manifestations of CVD. Despite the advances in the knowledge and management of each of the components of MetS, there are two molecular biology processes, chronic inflammation and oxidative stress, which are still underdiagnosed and undertreated. In order to assess the effect of a dietary supplement on chronic inflammation in MetS, we conducted a clinical trial with volunteers receiving a formula composed of resveratrol, piperine and alpha tocopherol (FRAMINTROL), together with their habitual treatment, for three months. The inflammatory state was evaluated by ultrasensitive C reactive protein (US CRP) and ferritin in plasma, and oxygen consumption and chemiluminescence in neutrophils. The results showed that ferritin decreased by 10% (p < 0.05), US-CRP by 33% (p < 0.0001), oxygen consumption by 55% (p < 0.0001), and spontaneous chemiluminiscence was by 25% (p < 0.005) after treatment. As far as we know, this is the first study showing a chronic inflammation decrease in MetS patients due to the administration of a biopower Resveratrol-piperine and alpha tocopherol dietary supplement together with conventional therapy.
C1 [Pastor, Raul Francisco; Manfredi Carabetti, Zulma; Pastor, Isabel; Pastor, Elena; Iermoli, Laura Valeria; Bavasso, Carlos Amadeo; Iermoli, Roberto Hector] Univ Buenos Aires, Hosp Clin Jose de San Martin, Fac Med, Unidad Polifenoles Vino & Salud,Cuarta Catedra Me, C1120AAF, Buenos Aires, DF, Argentina.
   [Repetto, Marisa Gabriela; Lairion, Fabiana] Univ Buenos Aires, Fac Farm & Bioquim, Dept Fisicoquim & Quim Analit, C1113AAD, Buenos Aires, DF, Argentina.
   [Repetto, Marisa Gabriela; Lairion, Fabiana] UBA, CONICET, Consejo Nacl Ciencia & Tecnol, Inst Bioquim & Med Mol IBIMOL, C1113AAD, Buenos Aires, DF, Argentina.
   [Lazarowski, Alberto; Merelli, Amalia] Univ Buenos Aires, Fac Farm & Bioquim, Dept Bioquim Clin, Inst Fisiopatol & Bioquim Clin INFIBIOC, C1113AAD, Buenos Aires, DF, Argentina.
C3 University of Buenos Aires; University of Buenos Aires Hospital;
   University of Buenos Aires; University of Buenos Aires; Consejo Nacional
   de Investigaciones Cientificas y Tecnicas (CONICET); University of
   Buenos Aires
RP Pastor, RF (corresponding author), Univ Buenos Aires, Hosp Clin Jose de San Martin, Fac Med, Unidad Polifenoles Vino & Salud,Cuarta Catedra Me, C1120AAF, Buenos Aires, DF, Argentina.
EM rpastor@fmed.uba.ar; mrepetto@ffyb.uba.ar; flairion@ffyb.uba.ar;
   nadiatom@ffyb.uba.ar; amerelli@ffyb.uba.ar;
   zulmamanfredi@tiempomedico.com.ar; ipastor@hospitaldeclinicas.uba.ar;
   epastor@hospitaldeclinicas.uba.ar; lauraiermoli@gmail.com;
   analisisintegrales@hotmail.com; riermoli@fmed.uba.ar
RI Pastor, Elena/L-2100-2014; Repetto, Marisa/R-5086-2016
OI Lazarowski, Alberto/0000-0001-8979-7631; Pastor, Raul
   Francisco/0000-0002-1722-8445
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NR 44
TC 14
Z9 16
U1 1
U2 12
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD OCT
PY 2020
VL 12
IS 10
AR 3149
DI 10.3390/nu12103149
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA OL3WN
UT WOS:000585274200001
PM 33076345
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Tae, H
   Huh, H
   Hwang, J
   Chae, J
AF Tae, Hyejin
   Huh, Hyu Jung
   Hwang, Jihyun
   Chae, Jeong-Ho
TI Relationship between serum lipid concentrations and posttraumatic stress
   symptoms in the bereaved after the Sewol ferry disaster: A prospective
   cohort study
SO PSYCHIATRY RESEARCH
LA English
DT Article
DE High-density lipoprotein cholesterol (HDL-C); Lipid; PTSD
ID MAJOR DEPRESSIVE DISORDER; HIGH-DENSITY-LIPOPROTEIN;
   CORONARY-ARTERY-DISEASE; MYOCARDIAL-INFARCTION; METABOLIC SYNDROME;
   CHOLESTEROL LEVELS; HEALTH BEHAVIORS; HDL-CHOLESTEROL; WAR VETERANS;
   RISK-FACTORS
AB The objective of this study was to investigate the relationship between serum lipid concentrations and PTSD symptoms in the bereaved after a traumatic familial loss. Eighteen months after the Sewol ferry disaster, 107 subjects who experienced traumatic losses as a result of the accident completed a mental and medical survey as well as laboratory tests for lipid profiles. At 30 months after the trauma, a total of 64 individuals completed a follow-up psychometric survey and biochemical measurements. We performed multiple linear regression analyses, examining the association between PTSD symptoms and lipid profiles. Other potential influences on lipid profiles such as metabolic risk factors, demographic risk factors, and underlying medical history were accounted for. Participants reporting clinically significant PTSD symptoms exhibited lower serum HDL-C levels than those without PTSD symptoms. In addition, we found that the severity of PTSD symptoms and sex could explain the changes in lipid profiles independently of other possible risk factors of changes. The results of this study suggest that PTSD symptoms may contribute to an increased risk for developing metabolic syndrome via detrimental changes in lipid concentrations. Routine screening and multidisciplinary management to prevent metabolic syndrome in individuals who experience traumatic losses would therefore be valuable.
C1 [Tae, Hyejin; Chae, Jeong-Ho] Catholic Univ Korea, Seoul St Marys Hosp, Coll Med, Dept Psychiat, 222 Banpo Daero, Seoul 06591, South Korea.
   [Huh, Hyu Jung] Catholic Univ Korea, Seoul St Marys Hosp, Hlth Promot Ctr, Stress Clin, Seoul, South Korea.
   [Hwang, Jihyun] Catholic Univ Korea, Catholic Biomed Ind Inst, Seoul, South Korea.
C3 Catholic University of Korea; Seoul St. Mary's Hospital; Seoul St.
   Mary's Hospital; Catholic University of Korea; Catholic University of
   Korea
RP Chae, J (corresponding author), Catholic Univ Korea, Seoul St Marys Hosp, Coll Med, Dept Psychiat, 222 Banpo Daero, Seoul 06591, South Korea.
EM alberto@catholic.ac.kr
RI Tae, Hyejin/IXD-9804-2023
FU Korean Mental Health Technology R&D Project, Ministry of Health &
   Welfare, Republic of Korea [HM15C1054]
FX This study was supported by a grant of the Korean Mental Health
   Technology R&D Project, Ministry of Health & Welfare, Republic of
   Korea(HM15C1054).
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NR 54
TC 8
Z9 8
U1 0
U2 6
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0165-1781
J9 PSYCHIAT RES
JI Psychiatry Res.
PD AUG
PY 2018
VL 266
BP 132
EP 137
DI 10.1016/j.psychres.2018.04.058
PG 6
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA GM1IP
UT WOS:000437819700020
PM 29864612
DA 2025-06-11
ER

PT J
AU Radojkovic, J
   Sikanic, N
   Bukumiric, Z
   Tadic, M
   Kostic, N
   Babic, R
AF Radojkovic, Jana
   Sikanic, Natasa
   Bukumiric, Zoran
   Tadic, Marijana
   Kostic, Nada
   Babic, Rade
TI Improvement of Glycemic Control in Insulin-Dependent Diabetics with
   Depression by Concomitant Treatment with Antidepressants
SO MEDICAL SCIENCE MONITOR
LA English
DT Article
DE Antidepressive Agents; Depression; Diabetes Mellitus, Type 2;
   Inflammation; Risk Factors; Serotonin Uptake Inhibitors
ID C-REACTIVE PROTEIN; CORONARY-HEART-DISEASE; ATORVASTATIN 80 MG;
   DOUBLE-BLIND; CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; COMPLETED
   TRIALS; RISK-FACTORS; ASSOCIATION; PREVALENCE
AB Background: It is still disputable whether negative effects of comorbid depression in diabetics can be diminished by successful treatment of depression. The primary aim of this study was to assess whether addition of antidepressants to existing insulin treatment would further improve glycemic control in these patients. A secondary objective was to assess whether such treatment impairs their lipid and inflammatory status.
   Material/Methods: Total of 192 patients with poorly controlled diabetes (defined as HbA1c >= 8%) in the absence of any uncontrolled medical condition entered the 6-month run-in phase with optimization of diabetic therapy. Depression status was screened at the end of this phase by BDI-II depression testing. Patients with BDI-II 3 14 and psychiatric confirmation of depression (58 patients) entered the 6-month interventional phase with SSRI class antidepressants.
   Results: Fifty patients completed the study. During the run-in phase, HbA1c dropped from 10.0 +/- 1.8% to 8.5 +/- 1.2% (p<0.001), and during the interventional phase it dropped from 8.5 +/- 1.2% to 7.7 +/- 0.7% (p<0.001). BDI-II scores improved significantly from 30.4 +/- 13.2 to 23.5 +/- 11.0 (p=0.02) during the interventional phase. A positive linear correlation between improvement in depression scale and improvement in glycemic control was observed (R-2=0.139, p=0.008). Lipid profile and inflammatory status did not change significantly during the interventional phase.
   Conclusions: Patients with poorly controlled diabetes and comorbid depression might benefit from screening and treatment of depression with SSRI antidepressants by achieving an incremental effect on glycoregulation. This therapy did not have any adverse effects on lipid profile or inflammatory status.
C1 [Radojkovic, Jana; Kostic, Nada] Clin Ctr Dr Dragisa Misovic, Dept Clin Endocrinol, Belgrade, Serbia.
   [Sikanic, Natasa] Clin Ctr Dr Dragisa Misovic, Dept Clin Psychiat, Belgrade, Serbia.
   [Bukumiric, Zoran] Univ Belgrade, Univ Sch Med, Dept Med Stat, Belgrade, Serbia.
   [Tadic, Marijana; Kostic, Nada; Babic, Rade] Univ Belgrade, Univ Sch Med, Dept Internal Med, Belgrade, Serbia.
C3 University of Belgrade; University of Belgrade
RP Babic, R (corresponding author), Univ Belgrade, Univ Sch Med, Dept Internal Med, Belgrade, Serbia.
EM drbabic@gmail.com
RI ; Babic, Rade/AAO-1507-2020
OI Bukumiric, Zoran/0000-0002-7609-4504; Babic, Rade/0000-0002-1674-9732
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NR 65
TC 7
Z9 9
U1 0
U2 14
PU INT SCIENTIFIC INFORMATION, INC
PI MELVILLE
PA 150 BROADHOLLOW RD, STE 114, MELVILLE, NY 11747 USA
EI 1643-3750
J9 MED SCI MONITOR
JI Med. Sci. Monitor
PD JUN 22
PY 2016
VL 22
BP 2133
EP 2143
DI 10.12659/MSM.899571
PG 11
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA DP1JR
UT WOS:000378246800001
PM 27329213
OA Green Published
DA 2025-06-11
ER

PT J
AU Zulhendri, F
   Ravalia, M
   Kripal, K
   Chandrasekaran, K
   Fearnley, J
   Perera, CO
AF Zulhendri, Felix
   Ravalia, Munir
   Kripal, Krishna
   Chandrasekaran, Kavita
   Fearnley, James
   Perera, Conrad O.
TI Propolis in Metabolic Syndrome and Its Associated Chronic Diseases: A
   Narrative Review
SO ANTIOXIDANTS
LA English
DT Review
DE propolis; metabolic syndrome; antioxidant; anti-inflammation; chronic
   diseases; cardiovascular; diabetes mellitus; chronic kidney disease;
   fatty liver disease; Alzheimer&#8217; s disease
ID IMPROVES INSULIN SENSITIVITY; STINGLESS BEE PROPOLIS; ACID PHENETHYL
   ESTER; DOUBLE-BLIND; ANTIOXIDANT ACTIVITY; REMNANT CHOLESTEROL;
   OXIDATIVE STRESS; GREEN PROPOLIS; BLOOD-PRESSURE; RISK
AB Propolis is a resinous product collected by bees from plants to protect and maintain the homeostasis of their hives. Propolis has been used therapeutically by humans for centuries. This review article attempts to analyze the potential use of propolis in metabolic syndrome (MetS) and its associated chronic diseases. MetS and its chronic diseases were shown to be involved in at least seven out of the top 10 causes of death in 2019. Patients with MetS are also at a heightened risk of severe morbidity and mortality in the present COVID-19 pandemic. Propolis with its antioxidant and anti-inflammatory properties is potentially useful in ameliorating the symptoms of MetS and its associated chronic diseases. The aim of this article is to provide a comprehensive review on propolis and its therapeutic benefit in MetS and its chronic diseases, with an emphasis on in vitro and in vivo studies, as well as human clinical trials. Moreover, the molecular and biochemical mechanisms of action of propolis are also discussed. Propolis inhibits the development and manifestation of MetS and its chronic diseases by inhibiting of the expression and interaction of advanced glycation end products (AGEs) and their receptors (RAGEs), inhibiting pro-inflammatory signaling cascades, and promoting the cellular antioxidant systems.
C1 [Zulhendri, Felix] Kebun Efi, North Sumatra 2217, Indonesia.
   [Ravalia, Munir] Royal London Hosp, Whitechapel Rd, London E1 1FR, England.
   [Kripal, Krishna] Rajarajeswari Dent Coll & Hosp, 14 Ramohalli Cross,Mysore Rd, Bengaluru 560074, Karnataka, India.
   [Chandrasekaran, Kavita] Peerzadiguda, Hyderabad 500039, Telangana, India.
   [Fearnley, James] Apiceut Res Ctr, Unit 3b Enterprise Way, Whitby YO18 7NA, N Yorkshire, England.
   [Perera, Conrad O.] Univ Auckland, Sch Chem Sci, Food Sci Program, 23 Symonds St, Auckland 1010, New Zealand.
C3 Barts Health NHS Trust; Royal London Hospital; University of Auckland
RP Zulhendri, F (corresponding author), Kebun Efi, North Sumatra 2217, Indonesia.; Ravalia, M (corresponding author), Royal London Hosp, Whitechapel Rd, London E1 1FR, England.; Perera, CO (corresponding author), Univ Auckland, Sch Chem Sci, Food Sci Program, 23 Symonds St, Auckland 1010, New Zealand.
EM felix.zulhendri@gmail.com; munirrav@yahoo.co.uk;
   kripalkrishna@yahoo.com; dr.ckavita@gmail.com;
   james.fearnley@beearc.com; conradperera@gmail.com
RI Chandrasekaran, Kavita/AAE-9973-2021
OI Zulhendri, Felix/0000-0002-7881-1845; Perera,
   Conrad/0000-0001-9525-6962; CHANDRASEKARAN, DR.
   KAVITA/0000-0002-6259-5607
FU Kebun Efi
FX This research received no external funding and the APC was funded by
   Kebun Efi.
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NR 208
TC 31
Z9 32
U1 0
U2 28
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD MAR
PY 2021
VL 10
IS 3
AR 348
DI 10.3390/antiox10030348
PG 20
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA RD2DJ
UT WOS:000633295300001
PM 33652692
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Khan, RS
   Newsome, PN
AF Khan, Reenam S.
   Newsome, Philip N.
TI Non-alcoholic fatty liver disease and liver transplantation
SO METABOLISM-CLINICAL AND EXPERIMENTAL
LA English
DT Article
DE Non-alcoholic fatty liver disease; Non-alcoholic steatohepatitis; Liver
   transplantation; Metabolic syndrome
ID CORONARY-ARTERY-DISEASE; SINGLE-CENTER EXPERIENCE; LONG-TERM OUTCOMES;
   BODY-MASS INDEX; POSTOPERATIVE CARDIOVASCULAR EVENTS; DOBUTAMINE STRESS
   ECHOCARDIOGRAPHY; RANDOMIZED-CONTROLLED-TRIAL; MAJOR NONCARDIAC SURGERY;
   POPULATION-BASED COHORT; METABOLIC SYNDROME
AB Cirrhosis secondary to non-alcoholic steatohepatitis (NASH) is a common indication for liver transplant. In comparison to other cirrhotic patients, patients with NASH cirrhosis are more likely to be older and have the metabolic syndrome. Pre transplant, patients require careful evaluation of cardiovascular risk.
   As the incidence of non-alcoholic fatty liver disease (NAFLD) is rising, a greater proportion of donor grafts have steatosis greater than 30%, which is associated with poor outcomes. Grafts with steatosis greater than 60% are unsuitable for transplant.
   Overall, post-transplant survival outcomes for patients with NASH cirrhosis are similar to those with cirrhosis without NASH. However, NASH cirrhosis is associated with a higher 30 day mortality, predominantly from an increase in cardiovascular events and infections. Following liver transplant, there is a significant risk of NASH recurrence, although this seldom results in allograft loss. Furthermore, a significant number of patients who had a liver transplant for other reasons develop NASH de nouo.
   When patients with NASH cirrhosis are considered for transplant, one of the major challenges lies in identifying which patients are too high risk for surgery. This review aims to provide information to aid this decision making process, and to provide guidance on the peri-operative care strategies that can modify risk. (C) 2016 Published by Elsevier Inc.
C1 [Khan, Reenam S.] Univ Birmingham, NIHR Birmingham Liver BRU, Gastroenterol & Hepatol, Birmingham B15 2TH, W Midlands, England.
   [Khan, Reenam S.; Newsome, Philip N.] Univ Birmingham, Liver Res Ctr, Birmingham B15 2TH, W Midlands, England.
   [Newsome, Philip N.] Univ Birmingham, NIHR Birmingham Liver BRU, Hepatol, Birmingham B15 2TH, W Midlands, England.
C3 University of Birmingham; University of Birmingham; University of
   Birmingham
RP Khan, RS (corresponding author), Univ Birmingham, NIHR Birmingham Liver BRU, Gastroenterol & Hepatol, Birmingham B15 2TH, W Midlands, England.; Khan, RS (corresponding author), Univ Birmingham, Liver Res Ctr, Birmingham B15 2TH, W Midlands, England.
EM rsk409@bham.ac.uk; P.N.Newsome@bham.ac.uk
RI Newsome, Philip/D-4495-2018
OI Newsome, Philip/0000-0001-6085-3652
FU MRC [MR/L022699/1] Funding Source: UKRI; Medical Research Council
   [MR/L022699/1] Funding Source: Medline
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NR 177
TC 39
Z9 41
U1 0
U2 8
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0026-0495
EI 1532-8600
J9 METABOLISM
JI Metab.-Clin. Exp.
PD AUG
PY 2016
VL 65
IS 8
BP 1208
EP 1223
DI 10.1016/j.metabol.2016.02.013
PG 16
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA DR4RH
UT WOS:000379889400018
PM 26997540
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Kwon, YE
   Ha, JE
   Paik, DI
   Jin, BH
   Bae, KH
AF Kwon, Young-Eun
   Ha, Jung-Eun
   Paik, Dai-Il
   Jin, Bo-Hyoung
   Bae, Kwang-Hak
TI The relationship between periodontitis and metabolic syndrome among a
   Korean nationally representative sample of adults
SO JOURNAL OF CLINICAL PERIODONTOLOGY
LA English
DT Article
DE Korean National Health and Nutrition Examination (KNHANES); metabolic
   syndrome; periodontal disease; relationship
ID AMERICAN-DIABETES-ASSOCIATION; OXIDATIVE STRESS; UNITED-STATES;
   INSULIN-RESISTANCE; CRITICAL-APPRAISAL; JOINT STATEMENT; YOUNG-ADULTS;
   DISEASE; DEFINITION; PREVALENCE
AB Aims: The aim of this study was to examine whether metabolic syndrome (MS) is associated with periodontitis in a representative sample of Korean adults, who were involved in the Fourth Korea National Health and Nutrition Examination Survey (KNHANES).
   Materials and Methods: A total of 7178 subjects over the age of 19 years who participated in KNHANES were examined. MS was defined as the definition proposed by the National Cholesterol Education Program Adult Treatment Panel III and the abdominal obesity cut-off line based on Korean Society for the Study of Obesity. The periodontal status was assessed by the Community Periodontal Index. Multivariate logistic regression analysis was carried out adjusting for the sociodemographics, oral health behaviours and status, and health behaviour. All analyses considered a complex sampling design, and multivariate analysis was also performed in the subgroups (age, gender, current smoking status).
   Results: Multivariate logistic regression analysis revealed significant associations between MS and periodontitis. After adjusting for all covariates, the adjusted odds ratio (OR) of periodontitis (community periodontal index >= 3) was 1.55 (1.32-1.83) for MS. In subgroup analysis, periodontitis is associated with MS in subjects over age 40 and the adjusted ORs were higher in females and in the smoker group than in males and in non-smokers.
   Conclusions: MS is associated with periodontitis.
C1 [Kwon, Young-Eun; Ha, Jung-Eun; Paik, Dai-Il; Jin, Bo-Hyoung; Bae, Kwang-Hak] Seoul Natl Univ, Sch Dent, Dept Prevent & Publ Hlth Dent, Seoul 110749, South Korea.
   [Kwon, Young-Eun] Korea Canc Ctr Hosp, Dept Dent, Seoul, South Korea.
   [Ha, Jung-Eun; Paik, Dai-Il; Jin, Bo-Hyoung; Bae, Kwang-Hak] Seoul Natl Univ, Dent Res Inst, Sch Dent, Seoul, South Korea.
C3 Seoul National University (SNU); National Cancer Center - Korea (NCC);
   Seoul National University (SNU)
RP Bae, KH (corresponding author), Seoul Natl Univ, Sch Dent, Dept Prevent & Publ Hlth Dent, 28 Yeongeuon Dong, Seoul 110749, South Korea.
EM baekh@snu.ac.kr
RI jin, bo-hyoung/AAU-8576-2021
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NR 43
TC 76
Z9 83
U1 0
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0303-6979
EI 1600-051X
J9 J CLIN PERIODONTOL
JI J. Clin. Periodontol.
PD SEP
PY 2011
VL 38
IS 9
BP 781
EP 786
DI 10.1111/j.1600-051X.2011.01756.x
PG 6
WC Dentistry, Oral Surgery & Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dentistry, Oral Surgery & Medicine
GA 806HA
UT WOS:000293795700001
PM 21722155
OA Bronze
DA 2025-06-11
ER

PT J
AU Li, XY
   Huang, HY
   Xu, HJ
   Shi, Y
   Qian, YJ
   Zou, JY
   Yi, HL
   Guan, J
   Yin, SK
AF Li, Xinyi
   Huang, Hengye
   Xu, Huajun
   Shi, Yue
   Qian, Yingjun
   Zou, Jianyin
   Yi, Hongliang
   Guan, Jian
   Yin, Shankai
TI Excessive daytime sleepiness, metabolic syndrome, and obstructive sleep
   apnea: two independent large cross-sectional studies and one
   interventional study
SO RESPIRATORY RESEARCH
LA English
DT Article
DE Obstructive sleep apnea; Excessive daytime sleepiness; Metabolic
   syndrome; Upper-airway surgery
ID INSULIN-RESISTANCE; OBESITY; ASSOCIATION; DEPRESSION; MODERATE; SCALE
AB Background: Obstructive sleep apnea (OSA) and excessive daytime sleepiness (EDS) were considered to contribute to MetS. This study was performed to assess the association between MetS and EDS in two independent large-scale populations, and in subjects who underwent upper-airway surgery.
   Methods: A total of 6312 patients without self-reported depression and 3578 suspected OSA patients were consecutively recruited, during health screening examinations and from our sleep center, respectively. A total of 57 subjects with OSA who underwent upper-airway surgery were also included. Demographic, anthropometric, biochemical, and polysomnographic data were obtained.
   Results: In the health screening examination group, 233 (9.23%) women and 350 (10.93%) men had complaints of EDS. A total of 229 (7.04%) women and 1182 (36.88%) men met the criteria for MetS. In the OSA group, 147 (21.18%) women and 1058 (36.69%) men reported EDS. In addition, 93 (13.4%) women and 1368 (47.43%) men reported MetS. In the health screening examination group, EDS did not contribute significantly to MetS (OR = 1.125, 95% CI: 0.907-1.395; p = 0.283). In the OSA group, EDS significantly contributed to MetS (OR = 1.249, 95% CI: 1.063-1.468; p = 0.007); however, the results were not significant after adjusting for sleep variables (OR = 1.071, 95% CI: 0.905-1.268; p = 0.423). Upper-airway surgery did not affect cardio-metabolic variables in OSA patients with or without EDS.
   Conclusions: EDS was not associated with MetS in two independent large-scale cohorts. In addition, upper-airway surgery did not affect components of MetS in OSA patients with and without EDS.
C1 [Li, Xinyi; Xu, Huajun; Qian, Yingjun; Zou, Jianyin; Yi, Hongliang; Guan, Jian; Yin, Shankai] Shanghai Jiao Tong Univ Affiliated Peoples Hosp 6, Dept Otolaryngol Head & Neck Surg, Yishan Rd 600, Shanghai 200233, Peoples R China.
   [Li, Xinyi; Xu, Huajun; Qian, Yingjun; Zou, Jianyin; Yi, Hongliang; Guan, Jian; Yin, Shankai] Shanghai Jiao Tong Univ Affiliated Peoples Hosp 6, Ctr Sleep Med, Yishan Rd 600, Shanghai 200233, Peoples R China.
   [Li, Xinyi; Xu, Huajun; Qian, Yingjun; Zou, Jianyin; Yi, Hongliang; Guan, Jian; Yin, Shankai] Shanghai Key Lab Sleep Disordered Breathing, Yishan Rd 600, Shanghai 200233, Peoples R China.
   [Li, Xinyi; Xu, Huajun; Qian, Yingjun; Zou, Jianyin; Yi, Hongliang; Guan, Jian; Yin, Shankai] Shanghai Jiao Tong Univ, Otolaryngol Inst, Yishan Rd 600, Shanghai 200233, Peoples R China.
   [Huang, Hengye; Shi, Yue] Shanghai Jiao Tong Univ, Sch Publ Hlth, Sch Med, 225South Chongqing Rd, Shanghai 200020, Peoples R China.
C3 Shanghai Jiao Tong University; Shanghai Jiao Tong University; Shanghai
   Jiao Tong University; Shanghai Jiao Tong University
RP Xu, HJ; Yi, HL (corresponding author), Shanghai Jiao Tong Univ Affiliated Peoples Hosp 6, Dept Otolaryngol Head & Neck Surg, Yishan Rd 600, Shanghai 200233, Peoples R China.; Xu, HJ; Yi, HL (corresponding author), Shanghai Jiao Tong Univ Affiliated Peoples Hosp 6, Ctr Sleep Med, Yishan Rd 600, Shanghai 200233, Peoples R China.
EM sunnydayxu2010@163.com; yihongl@126.com
RI li, xinyi/GWZ-8941-2022; xu, huajun/KQT-9241-2024
FU National Key R&D Program of China [2017YFC0112500]; Joint Project of New
   Frontier Technology of Shanghai Shen-kang Hospital Development Center
   [SHDC 12014240, 16CR3103B]; Innovation Program of Shanghai Municipal
   Education Commission [2017-01-07-00-02-E00047]; National Natural Science
   Foundation of China [81770987, 81700896, 81701306, 81770988]; Shanghai
   Sailing Program [17YF1414300]; multi-center clinical research project
   from school of medicine, Shanghai Jiao Tong University [DLY201502];
   Shanghai Shen-Kang Hospital Management Center [SHDC12015101]
FX This study was supported by grants-in-aid from National Key R&D Program
   of China (2017YFC0112500); The Joint Project of New Frontier Technology
   of Shanghai Shen-kang Hospital Development Center (SHDC 12014240,
   16CR3103B); Innovation Program of Shanghai Municipal Education
   Commission (2017-01-07-00-02-E00047); National Natural Science
   Foundation of China (81770987, 81700896, 81701306, 81770988); Shanghai
   Sailing Program (17YF1414300); multi-center clinical research project
   from school of medicine, Shanghai Jiao Tong University (DLY201502) and
   Shanghai Shen-Kang Hospital Management Center Project (SHDC12015101).
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NR 34
TC 13
Z9 14
U1 0
U2 7
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1465-993X
J9 RESP RES
JI Respir. Res.
PD DEC 4
PY 2019
VL 20
IS 1
AR 276
DI 10.1186/s12931-019-1248-y
PG 8
WC Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Respiratory System
GA KH8YJ
UT WOS:000510936000003
PM 31801522
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Zheng, NN
   Wei, D
   Dai, B
   Zheng, LY
   Zhao, MY
   Xin, N
   Chi, ZH
   Zhao, YT
   Ma, TX
   Jahane, R
   Sun, LN
AF Zheng, Ningning
   Wei, Dan
   Dai, Bo
   Zheng, Lanyan
   Zhao, Mingyi
   Xin, Na
   Chi, Zhihong
   Zhao, Yiting
   Ma, Tingxian
   Jahane, Rabita
   Sun, Luning
TI Mitochondrial Genome Encoded Proteins Expression Disorder, the Possible
   Mechanism of the Heart Disease in Metabolic Syndrome
SO CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
LA English
DT Article
DE Metabolic Syndrome; Heart Disease; Mitochondrion Encoded Protein;
   Mitochondrial Ribosomal Proteins
ID ELECTRON-TRANSFER FLAVOPROTEIN; OXIDATIVE STRESS; ATP SYNTHESIS; DNA
   MUTATION; TRANSPORT; ADULTS; CHAIN; NARP; PROLIFERATION; DEGRADATION
AB Background/Aims: The direct consequence of metabolic syndrome (MS) is the increased morbidity and mortality caused by the heart disease. We tried to explain why the heart is more severely damaged during MS from the point of mitochondria, the center of cellular metabolism. Methods: 1. The classic diet induced MS rat model was used to observe the morphological changes of mitochondria by transmission electron microscope (TEM); 2. The expression of mitochondrial DNA (mt-DNA) encoded proteins was observed by immunohistochemistry and Western blot; 3. The expression of mitochondrial ribosomal proteins (MRPs) was observed by real-time PCR. Results: 1. The mitochondrial volume increased but the number was normal in myocardial cells of the MS rats. But in the hepatocytes and skeletal muscle cells, the mitochondrial number decreased; 2. The mt-DNA encoded protein cytochrome b increased significantly in heart but decreased in liver and the ATPase6 increased in liver but decreased in heart of the MS rats; 3. The mRNA levels of MRPS23, MRPL27, MRPL45 and MRPL48 elevated in heart but down-regulated in liver of the MS rats. Conclusion: The morphologic and functional alterations of mitochondrion in MS were tissue specific. Heart displays a distinctive pattern of mitochondrial metabolic status compared with other tissues. (C) 2017 The Author(s) Published by S. Karger AG, Basel
C1 [Zheng, Ningning; Xin, Na; Chi, Zhihong; Ma, Tingxian; Sun, Luning] China Med Univ, Coll Basic Med Sci, Dept Pathophysiol, Shenyang, Liaoning, Peoples R China.
   [Wei, Dan; Dai, Bo] China Med Univ, Grad Sch, Dept Pathophysiol, Shenyang, Liaoning, Peoples R China.
   [Zheng, Lanyan] China Med Univ, Coll Basic Med Sci, Dept Pathogen Biol, Shenyang, Liaoning, Peoples R China.
   [Zhao, Mingyi] Shenyang Pharmaceut Univ, Dept Clin Pharm, Shenyang, Liaoning, Peoples R China.
   [Zhao, Yiting] Chinese Acad Med Sci, Canc Hosp, PET CT Ctr, Beijing, Peoples R China.
   [Jahane, Rabita] China Med Univ, Int Educ Sch, Shenyang, Liaoning, Peoples R China.
C3 China Medical University; China Medical University; China Medical
   University; Shenyang Pharmaceutical University; Chinese Academy of
   Medical Sciences - Peking Union Medical College; Cancer Institute &
   Hospital - CAMS; China Medical University
RP Sun, LN (corresponding author), China Med Univ, Coll Basic Med Sci, Dept Pathophysiol, Shenyang North New Area, 77 Puhe Rd, Shenyang, Liaoning, Peoples R China.
EM lnsun@cmu.edu.cn
RI Zheng, Ningning/KHU-0389-2024; Zhang, Tingting/GXF-5248-2022
FU National Natural Science Foundation of China [30900567]
FX This work was supported by a grant from National Natural Science
   Foundation of China (30900567).
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NR 44
TC 8
Z9 10
U1 0
U2 7
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1015-8987
EI 1421-9778
J9 CELL PHYSIOL BIOCHEM
JI Cell. Physiol. Biochem.
PY 2017
VL 43
IS 3
BP 959
EP 968
DI 10.1159/000481649
PG 10
WC Cell Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Physiology
GA FN7TI
UT WOS:000416221300008
PM 28957804
OA gold
DA 2025-06-11
ER

PT J
AU Hwang, AC
   Lin, YC
   Liu, PT
   Kao, YM
   Chen, JD
AF Hwang, An-Chun
   Lin, Yu-Cheng
   Liu, Peng-Tzu
   Kao, Yu-Man
   Chen, Jong-Dar
TI Synergistic effect of gamma glutamyltransferase and obesity on metabolic
   syndrome, independent of hepatic steatosis
SO ANNALS OF EPIDEMIOLOGY
LA English
DT Article
DE Metabolic syndrome; Insulin resistance; Cardiovascular diseases;
   Gammaglutamyltransferase; Obesity; Body mass index
ID GLUTAMYL-TRANSFERASE; CARDIOVASCULAR-DISEASE; OXIDATIVE STRESS; RISK;
   TRANSPEPTIDASE; MORTALITY; HEART; ATHEROSCLEROSIS; ASSOCIATION; ADULTS
AB Purpose: Both obesity and gamma glutamyltransferase (GGT) are individually considered to be closely associated with metabolic syndrome (MetS). Whether the 2 factors synergistically associate with MetS is not yet confirmed. The purpose of this study was to investigate whether obesity and GGT are interactively associated with MetS.
   Methods: A cross-sectional study of 7390 adults (age 32-62 years old) was conducted from 2009 to 2010.
   Results: Our results showed that greater serum GGT quartiles were positively associated with all MetS components and fatty liver (P < .001). The odds ratio of MetS increased significantly along with quartiles of GGT and obesity. In comparison with subjects with normal body mass index and first quartile GGT, the odds ratio of MetS in obese groups with 1st, 2nd, 3rd, and 4th quartile GGT were 6.8, 14.5, 20.3, and 45.2, respectively, and it remained tenable after adjustment for fatty liver. The synergy index of GGT and obesity on MetS is 2.2 (95% confidence interval, 1.9-2.6).
   Conclusions: Serum GGT level in combination with obesity can be a simple but useful tool for risk stratification of developing MetS. Obese individuals with high normal GGT levels require close monitoring for high risk of MetS. (C) 2012 Elsevier Inc. All rights reserved.
C1 [Hwang, An-Chun; Liu, Peng-Tzu; Kao, Yu-Man; Chen, Jong-Dar] Shin Kong Wu Ho Su Mem Hosp, Dept Family Med, Taipei 111, Taiwan.
   [Lin, Yu-Cheng] En Chu Kong Hosp, Dept Occupat Med, Taipei, Taiwan.
   [Chen, Jong-Dar] Fu Jen Catholic Univ, Sch Med, Taipei, Taiwan.
C3 Shin Kong Wu Ho Su Memorial Hospital; Fu Jen Catholic University
RP Chen, JD (corresponding author), Shin Kong Wu Ho Su Mem Hosp, Dept Family Med, 95 Wen Chang Rd, Taipei 111, Taiwan.
EM m006671@ms.skh.org.tw
RI Liu, Chia-Ju/AAX-8643-2021
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NR 26
TC 6
Z9 7
U1 0
U2 3
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1047-2797
EI 1873-2585
J9 ANN EPIDEMIOL
JI Ann. Epidemiol.
PD DEC
PY 2012
VL 22
IS 12
BP 876
EP 880
DI 10.1016/j.annepidem.2012.09.012
PG 5
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA 052XA
UT WOS:000312232400008
PM 23110960
DA 2025-06-11
ER

PT J
AU Santiago, E
   Climent, B
   Muñoz, M
   García-Sacristán, A
   Rivera, L
   Prieto, D
AF Santiago, Elvira
   Climent, Belen
   Munoz, Mercedes
   Garcia-Sacristan, Albino
   Rivera, Luis
   Prieto, Dolores
TI Hydrogen peroxide activates store-operated Ca<SUP>2+</SUP> entry in
   coronary arteries
SO BRITISH JOURNAL OF PHARMACOLOGY
LA English
DT Article
ID ADRENERGIC-RECEPTOR STIMULATION; CALCIUM INFLUX; INOSITOL
   1,4,5-TRISPHOSPHATE; OXIDATIVE STRESS; HYPERPOLARIZING FACTOR; REDOX
   REGULATION; CONCISE GUIDE; RELEASE; CHANNEL; OBESE
AB BACKGROUND AND PURPOSE
   Abnormal Ca2+ metabolism has been involved in the pathogenesis of vascular dysfunction associated with oxidative stress. Here, we have investigated the actions of H2O2 on store-operated Ca2+ (SOC) entry in coronary arteries and assessed whether it is impaired in arteries from a rat model of metabolic syndrome.
   EXPERIMENTAL APPROACH
   Simultaneous measurements of intracellular Ca2+ concentration and contractile responses were made in coronary arteries from Wistar and obese Zucker rats, mounted in microvascular myographs, and the effects of H2O2 were assessed.
   KEY RESULTS
   H2O2 raised intracellular Ca2+ concentrations, accompanied by simultaneous vasoconstriction that was markedly reduced in a Ca2+-free medium. Upon Ca2+ re-addition, a nifedipine-resistant sustained Ca2+ entry, not coupled to contraction, was obtained in endothelium-denuded coronary arteries. The effect of H2O2 on this voltage-independent Ca2+ influx was concentration-dependent, and high micromolar H2O2 concentrations were inhibitory and reduced SOC entry evoked by inhibition of the sarcoplasmic reticulum ATPase (SERCA). H2O2-induced increases in Fura signals were mimicked by Ba2+ and reduced by heparin, Gd3+ ions and by Pyr6, a selective inhibitor of the Orai1-mediated Ca2+ entry,. In coronary arteries from obese Zucker rats, intracellular Ca2+ mobilization and SOC entry activated by acute exposure to H2O2 were augmented and associated with local oxidative stress.
   CONCLUSION AND IMPLICATIONS
   H2O2 exerted dual concentration-dependent stimulatory/inhibitory effects on store-operated, IP3 receptor-mediated and Orai1-mediated Ca2+ entry, not coupled to vasoconstriction in coronary vascular smooth muscle. SOC entry activated by H2O2 was enhanced and associated with vascular oxidative stress in coronary arteries in metabolic syndrome.
C1 [Santiago, Elvira; Climent, Belen; Munoz, Mercedes; Garcia-Sacristan, Albino; Rivera, Luis; Prieto, Dolores] Univ Complutense Madrid, Fac Farm, Dept Fisiol, E-28040 Madrid, Spain.
C3 Complutense University of Madrid
RP Prieto, D (corresponding author), Univ Complutense Madrid, Fac Farm, Dept Fisiol, E-28040 Madrid, Spain.
EM dprieto@ucm.es
RI Rivera de los Arcos, Luis/T-2247-2018; Climent, Belen/P-2416-2015;
   PRIETO, DOLORES/S-8172-2018
OI Rivera de los Arcos, Luis/0000-0002-0187-707X; Climent,
   Belen/0000-0003-0852-9227; PRIETO, DOLORES/0000-0001-7049-5991; Munoz
   Picos, Mercedes/0000-0002-1679-9588
FU MINECO, Spain [SAF 2012-31631]
FX This work was supported by grant SAF 2012-31631 from MINECO, Spain. We
   thank Francisco Puente and Manuel Perales for their expert technical
   assistance.
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NR 66
TC 19
Z9 20
U1 0
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0007-1188
EI 1476-5381
J9 BRIT J PHARMACOL
JI Br. J. Pharmacol.
PD NOV
PY 2015
VL 172
IS 22
BP 5318
EP 5332
DI 10.1111/bph.13322
PG 15
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA CX0RB
UT WOS:000365403200008
PM 26478127
OA Green Published
DA 2025-06-11
ER

PT J
AU Khan, MAH
   Neckár, J
   Haines, J
   Imig, JD
AF Khan, Md. Abdul Hye
   Neckar, Jan
   Haines, Jasmine
   Imig, John D.
TI Azilsartan Improves Glycemic Status and Reduces Kidney Damage in Zucker
   Diabetic Fatty Rats
SO AMERICAN JOURNAL OF HYPERTENSION
LA English
DT Article
DE azilsartan medoxomil; blood pressure; hypertension; inflammation; kidney
   injury; oxidative stress; type 2 diabetes
ID STAGE RENAL-DISEASE; OXIDATIVE STRESS; ENDOTHELIAL DYSFUNCTION; RECEPTOR
   ANTAGONIST; METABOLIC SYNDROME; ANGIOTENSIN; BLOCKADE; IRBESARTAN;
   GLUCOSE; INJURY
AB BACKGROUND
   Azilsartan medoxomil (AZL-M), an angiotensin II receptor blocker, demonstrates antihypertensive and organ protective effects in hypertension. We investigated the efficacy of AZL-M to ameliorate metabolic syndrome and kidney damage associated with type 2 diabetes using Zucker diabetic fatty (ZDF) rats.
   METHODS
   ZDF rats were treated with vehicle or AZL-M for 8 weeks. Zucker diabetic lean (ZDL) rats were used as controls. Urine and plasma samples were collected for biochemical analysis, and kidney tissues were used for histopathological and immunohistopathological examination at the end of the 8-week protocol.
   RESULTS
   ZDF rats were diabetic with hyperglycemia and impaired glucose tolerance, and AZL-M ameliorated the diabetic phenotype. ZDF rats were hypertensive compared with ZDL rats (181 +/- 6 vs. 129 +/- 7 mm Hg), and AZL-M decreased blood pressure in ZDF rats (116 +/- 7 mm Hg). In ZDF rats, there was marked renal damage with elevated proteinuria, albuminuria, nephrinuria, 2-4-fold higher tubular cast formation, and glomerular injury compared with ZDL rats. AZL-M treatment reduced renal damage in ZDF rats. ZDF rats demonstrated renal inflammation and oxidative stress with elevated urinary monocyte chemoattractant protein 1 excretion, renal infiltration of macrophages, and elevated kidney malondialdehyde levels. AZL-M reduced oxidative stress and inflammation in ZDF rats.
   CONCLUSIONS
   Overall, we demonstrate that AZL-M attenuates kidney damage in type 2 diabetes. We further demonstrate that anti-inflammatory and antioxidative activities of AZL-M contribute to its kidney protective action.
C1 [Khan, Md. Abdul Hye; Neckar, Jan; Haines, Jasmine; Imig, John D.] Med Coll Wisconsin, Dept Pharmacol & Toxicol, Milwaukee, WI 53226 USA.
   [Neckar, Jan] Acad Sci Czech Republ, Inst Physiol, Prague, Czech Republic.
   [Imig, John D.] Med Coll Wisconsin, Ctr Cardiovasc, Milwaukee, WI 53226 USA.
C3 Medical College of Wisconsin; Czech Academy of Sciences; Institute of
   Physiology of the Czech Academy of Sciences; Medical College of
   Wisconsin
RP Imig, JD (corresponding author), Med Coll Wisconsin, Dept Pharmacol & Toxicol, Milwaukee, WI 53226 USA.
EM jdimig@mcw.edu
RI ; Neckar, Jan/C-6645-2012
OI Khan, Md Abdul Hye/0000-0001-5940-9300; Imig, John/0000-0002-9668-2899;
   Neckar, Jan/0000-0002-1187-9992
FU Takeda Pharmaceuticals USA; Midwest Affiliate of the American Heart
   Association
FX We acknowledge technical assistance provided by Katherine A. Walsh and
   Priyanka Nervatla from the Department of Pharmacology & Toxicology,
   Medical College of Wisconsin. These works were supported by a grant from
   Takeda Pharmaceuticals USA. Md. Abdul Hye Khan is a recipient of
   Postdoctoral Fellowship from the Midwest Affiliate of the American Heart
   Association.
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NR 42
TC 16
Z9 16
U1 0
U2 5
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0895-7061
EI 1941-7225
J9 AM J HYPERTENS
JI Am. J. Hypertens.
PD AUG
PY 2014
VL 27
IS 8
BP 1087
EP 1095
DI 10.1093/ajh/hpu016
PG 9
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA AP7DL
UT WOS:000342237900020
PM 24598210
OA Bronze
DA 2025-06-11
ER

PT J
AU Luo, HW
   Deng, ZX
   Liu, L
   Shen, L
   Kou, H
   He, Z
   Ping, J
   Xu, D
   Ma, L
   Chen, LB
   Wang, H
AF Luo, Hanwen
   Deng, Zixin
   Liu, Lian
   Shen, Lang
   Kou, Hao
   He, Zheng
   Ping, Jie
   Xu, Dan
   Ma, Lu
   Chen, Liaobin
   Wang, Hui
TI Prenatal caffeine ingestion induces transgenerational neuroendocrine
   metabolic programming alteration in second generation rats
SO TOXICOLOGY AND APPLIED PHARMACOLOGY
LA English
DT Article
DE Caffeine; Intrauterine growth retardation; Chronic stimulation;
   Hypothalamus-pituitary-adrenal axis; Glucose and lipid metabolism;
   Transgenerational inheritance
ID INTRAUTERINE GROWTH-RETARDATION; CARDIOVASCULAR RISK; FETAL; PREGNANCY;
   GLUCOSE; GLUCOCORTICOIDS; RESTRICTION; CONSUMPTION; EXPOSURE;
   ADIPONECTIN
AB Our previous studies have demonstrated that prenatal caffeine ingestion induces an increased susceptibility to metabolic syndrome with alterations of glucose and lipid metabolic phenotypes in adult first generation (F1) of intrauterine growth retardation (IUGR) rats, and the underlying mechanism is originated from a hypothalamic-pituitary-adrenal (HPA) axis-associated neuroendocrine metabolic programming alteration in utero. This study aims to investigate the transgenerational effects of this programming alteration in adult second generation (F2). Pregnant Wistar rats were administered with caffeine (120 mg/kg.d) from gestational day 11 until delivery. Four groups in F2 were set according to the cross-mating between control and caffeine-induced IUGR rats. F2 were subjected to a fortnight ice water swimming stimulus on postnatal month 4, and blood samples were collected before and after stress. Results showed that the majority of the activities of HPA axis and phenotypes of glucose and lipid metabolism were altered in F2. Particularly, comparing with the control group, caffeine groups had an enhanced corticosterone levels after chronic stress. Compared with before stress, the serum glucose levels were increased in some groups whereas the triglyceride levels were decreased. Furthermore, total cholesterol gain rates were enhanced but the high-density lipoprotein-cholesterol gain rates were decreased in most caffeine groups after stress. These transgenerational effects were characterized partially with gender and parental differences. Taken together, these results indicate that the reproductive and developmental toxicities and the neuroendocrine metabolic programming mechanism by prenatal caffeine ingestion have transgenerational effects in rats, which may help to explain the susceptibility to metabolic syndrome and associated diseases in F2. (C) 2013 Elsevier Inc. All rights reserved.
C1 [Luo, Hanwen; Deng, Zixin; Liu, Lian; Shen, Lang; Kou, Hao; He, Zheng; Ping, Jie; Xu, Dan; Wang, Hui] Wuhan Univ, Basic Med Sch, Dept Pharmacol, Wuhan 430071, Peoples R China.
   [Luo, Hanwen; Chen, Liaobin] Wuhan Univ, Zhongnan Hosp, Dept Orthoped Surg, Wuhan 430071, Peoples R China.
   [Ping, Jie; Xu, Dan; Wang, Hui] Wuhan Univ, Res Ctr Food & Drug Evaluat, Wuhan 430071, Peoples R China.
   [Ma, Lu] Wuhan Univ, Sch Publ Hlth, Dept Epidemiol & Hlth Stat, Wuhan 430071, Peoples R China.
C3 Wuhan University; Wuhan University; Wuhan University; Wuhan University
RP Chen, LB (corresponding author), Wuhan Univ, Zhongnan Hosp, Dept Orthoped Surg, Wuhan 430071, Peoples R China.
EM lbchen@whu.edu.cn; wanghui19@whu.edu.cn
FU National Natural Science Foundation of China [30830112, 81072709,
   81220108026, 81202240]; Chinese Ministry of Education [V200801];
   National Science & Technology Pillar Program of China [2013BAI12B01-3]
FX This work was supported by grants from the National Natural Science
   Foundation of China (Nos. 30830112, 81072709, 81220108026, 81202240),
   the Key Grant Project of the Chinese Ministry of Education (No.
   V200801), and the National Science & Technology Pillar Program of China
   (No. 2013BAI12B01-3).
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NR 49
TC 31
Z9 32
U1 1
U2 27
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0041-008X
EI 1096-0333
J9 TOXICOL APPL PHARM
JI Toxicol. Appl. Pharmacol.
PD FEB 1
PY 2014
VL 274
IS 3
BP 383
EP 392
DI 10.1016/j.taap.2013.11.020
PG 10
WC Pharmacology & Pharmacy; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Toxicology
GA AA5QR
UT WOS:000331155200003
PM 24321341
DA 2025-06-11
ER

PT J
AU Arnaud, AM
   Brister, TS
   Duckworth, K
   Foxworth, P
   Fulwider, T
   Suthoff, ED
   Werneburg, B
   Aleksanderek, I
   Reinhart, ML
AF Arnaud, Alix M.
   Brister, Teri . S.
   Duckworth, Ken
   Foxworth, Phyllis
   Fulwider, Tonya
   Suthoff, Ellison D.
   Werneburg, Brian
   Aleksanderek, Izabela
   Reinhart, Marcia L.
TI Impact of Major Depressive Disorder on Comorbidities: A Systematic
   Literature Review
SO JOURNAL OF CLINICAL PSYCHIATRY
LA English
DT Review
ID CORONARY-HEART-DISEASE; ANTIDEPRESSANT MEDICATION;
   CARDIOVASCULAR-DISEASE; PSYCHOLOGICAL DISTRESS; METABOLIC SYNDROME;
   DIABETES-MELLITUS; MENTAL-ILLNESS; INCREASED RISK; FOLLOW-UP; LIFE-SPAN
AB Objective: To summarize the breadth of data exploring the relationship between major depressive disorder (MDD) and both the incidence and the disease course of a range of comorbidities.Data Sources: The authors searched MEDLINE, Embase, PsycINFO, Cochrane Database of Systematic Reviews, and several prespecified congresses. Searches included terms related to MDD and several comorbidity categories, restricted to those published in the English language from 2005 onward.StudySelection: Eligibility criteria included observational studies within North America and Europe that examined the covariate-adjusted impact of MDD on the risk and/or severity of comorbidities. A total of 6,811 articles were initially identified for screening.Data Extraction:Two investigators extracted data and assessed study quality.Results: In total, 199 articles were included. Depression was significantly (P<.05) associated with an increased incidence of dementia and Alzheimer's disease as well as cognitive decline in individuals with existing disease; increased incidence and worsening of cardiovascular disease/events (although mixed results were found for stroke); worsening of metabolic syndrome; increased incidence of diabetes, particularly among men, and worsening of existing diabetes; increased incidence of obesity, particularly among women; increased incidence and worsening of certain autoimmune diseases; increased incidence and severity of HIV/AIDS; and increased incidence of drug abuse and severity of both alcohol and drug abuse. Conclusions: The presence of MDD was identified as a risk factor for both the development and the worsening of a range of comorbidities.These results highlight the importance of addressing depression early in its course and the need for integrating mental and general health care.
C1 [Arnaud, Alix M.; Suthoff, Ellison D.; Werneburg, Brian] Sage Therapeut Inc, Cambridge, MA USA.
   [Brister, Teri . S.; Duckworth, Ken] Natl Alliance Mental Illness NAMI, Arlington, VA USA.
   [Foxworth, Phyllis] Depress & Bipolar Support Alliance, Chicago, IL USA.
   [Fulwider, Tonya] Mental Hlth Amer Ohio, Columbus, OH USA.
   [Aleksanderek, Izabela; Reinhart, Marcia L.] Tantalus Med Commun Ltd, Victoria, BC, Canada.
   [Suthoff, Ellison D.] 215 First St, Cambridge, MA 02142 USA.
RP Suthoff, ED (corresponding author), 215 First St, Cambridge, MA 02142 USA.
EM Ellison.Suthoff@sagerx.com
OI Arnaud, Alix/0000-0003-1193-4258
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   World Health Organization, DEPR KEY FACTS
NR 76
TC 57
Z9 61
U1 6
U2 11
PU PHYSICIANS POSTGRADUATE PRESS
PI MEMPHIS
PA P O BOX 752870, MEMPHIS, TN 38175-2870 USA
SN 0160-6689
EI 1555-2101
J9 J CLIN PSYCHIAT
JI J. Clin. Psychiatry
PD NOV-DEC
PY 2022
VL 83
IS 6
AR 21r14328
DI 10.4088/JCP.21r14328
PG 134
WC Psychology, Clinical; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA E9NI4
UT WOS:000978719100005
PM 36264099
OA Bronze
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Geoffroy, PA
   Godin, O
   Mahee, D
   Henry, C
   Aubin, V
   Azorin, JM
   Bougerol, T
   Courtet, P
   Gard, S
   Kahn, JP
   Passerieux, C
   Leboyer, M
   Bellivier, F
   Etain, B
AF Geoffroy, Pierre A.
   Godin, Ophelia
   Mahee, Diane
   Henry, Chantal
   Aubin, Valerie
   Azorin, Jean-Michel
   Bougerol, Thierry
   Courtet, Philippe
   Gard, Sebastien
   Kahn, Jean-Pierre
   Passerieux, Christine
   Leboyer, Marion
   Bellivier, Frank
   Etain, Bruno
CA FACE-BD coll
TI Seasonal pattern in bipolar disorders and cardio-vascular risk factors:
   A study from the FACE-BD cohort
SO CHRONOBIOLOGY INTERNATIONAL
LA English
DT Article
DE Bipolar disorder; circadian rhythms; depression; metabolic syndrome;
   seasonal affective disorder
ID MAJOR DEPRESSIVE DISORDER; METABOLIC SYNDROME; MELATONIN SUPPRESSION;
   CIRCADIAN-RHYTHMS; MENTAL-DISORDERS; MOOD DISORDERS; LIGHT THERAPY;
   METAANALYSIS; PREVALENCE; MORTALITY
AB Seasonal pattern (SP) and metabolic syndrome (MetS) are major contributors to poor outcome in bipolar disorders (BD). Patients with seasonal bipolar depression present increased appetite, carbohydrate cravings, weight gain, and hypersomnia, which can increase the development of MetS. MetS also appears to be associated with seasonal mood changes in the general population. This study examines whether a SP in BD is associated with an increased risk of MetS and its sub-components. One thousand four hundred and seventy-one outpatients with BD were systematically enrolled from 2009 to 2016. Inclusion required a disease duration of at least 5 years, with 486 (33%) patients with SP (SP+) and 985 (67%) without (SP-) according to the DSM IV-TR criteria. When using continuous measures of metabolic components, SP+ patients, as compared to SP-, suffered from higher levels for systolic blood pressure (p = 0.01), low-density lipoprotein cholesterol (p = 0.009), fasting glucose (p = 0.007), triglycerides levels (p = 0.03), a larger abdominal circumference (p = 0.02), and a higher body mass index (p = 0.07). In the covariance analysis, adjusted for gender, age, and bipolar subtype, as well as the number of depressive and hypomanic episode, SP+ patients had a significantly higher level of fasting glucose and higher systolic blood pressure. The frequency of MetS did not differ between groups (21.2% in SP- versus 23.9% in SP+). When using categorical definitions for abnormal metabolic components (International Diabetes Federation criteria), there were no differences between groups, except that SP+ patients were more overweight/obese as compared to SP- patients (55.03% versus 46.7%, respectively; p = 0.002) and tended to have more frequently high fasting glucose (18.2% versus 14.3%, respectively; p = 0.07). MetS was frequent in patients with BD, however not associated with SP. Patients with SP appeared more vulnerable to overweight/obesity and presented with higher levels of MetS subcomponents although these parameters were mainly in the normal range. All patients with BD should benefit from early screening and targeted management of cardio-vascular risk factors.
C1 [Geoffroy, Pierre A.; Mahee, Diane; Bellivier, Frank; Etain, Bruno] GH St Louis Lariboisiere F Widal, AP HP, Dept Psychiat & Med Addictol, Paris, France.
   [Geoffroy, Pierre A.; Bellivier, Frank; Etain, Bruno] Univ Paris Diderot, Sorbonne Paris Cite, Paris, France.
   [Geoffroy, Pierre A.; Bellivier, Frank; Etain, Bruno] INSERM, U1144, Paris, France.
   [Geoffroy, Pierre A.; Godin, Ophelia; Henry, Chantal; Aubin, Valerie; Azorin, Jean-Michel; Bougerol, Thierry; Courtet, Philippe; Gard, Sebastien; Kahn, Jean-Pierre; Passerieux, Christine; Leboyer, Marion; Bellivier, Frank; Etain, Bruno] Fdn FondaMental, Creteil, France.
   [Godin, Ophelia; Henry, Chantal; Leboyer, Marion] INSERM, U955, Equipe Psychiat Translat, Creteil, France.
   [Godin, Ophelia] Univ Paris 06, Sorbonne Univ, IPLESP, UMRS 1136, Paris, France.
   [Godin, Ophelia] INSERM, UMR S 1136, F-75013 Paris, France.
   [Henry, Chantal; Leboyer, Marion] Univ Paris Est, Fac Med, Creteil, France.
   [Leboyer, Marion] Hop Univ Henri Mondor, AP HP, DHU Pepsy, Pole Psychiat & Addictol, Creteil, France.
   [Henry, Chantal] Inst Pasteur, Unite Percept & Mem, Paris, France.
   [Aubin, Valerie] Ctr Hosp Princesse Grace, Serv Psychiat, Ave Pasteur, Monaco, Monaco.
   [Azorin, Jean-Michel] Hop St Marguerite, AP HM, Pole Psychiat, Marseille, France.
   [Azorin, Jean-Michel] Aix Marseille Univ, CNRS, CRN2M, UMR 7286, Marseille, France.
   [Bougerol, Thierry] CHU Grenoble, Clin Univ Psychiat, Grenoble, France.
   [Courtet, Philippe] Univ Montpellier I, CHRU Montpellier, Dept Urgence & Post Urgence Psychiat, INSERM,U1061, Montpellier, France.
   [Gard, Sebastien] Ctr Hosp Charles Perrens, Pole Psychiat Gen Univ, Bordeaux, France.
   [Kahn, Jean-Pierre] Univ Lorraine, CHRU Nancy, 1 Rue Docteur Archambault, Laxou, France.
   [Kahn, Jean-Pierre] Ctr Psychotherap Nancy, Pole Psychiat & Psychol Clin 6, 1 Rue Docteur Archambault, Laxou, France.
   [Kahn, Jean-Pierre] Univ Versailles St Quentin, Ctr Hosp Versailles, Serv Psychiat Adulte, Le Chesnay, France.
C3 Assistance Publique Hopitaux Paris (APHP); Universite Paris Cite;
   Hopital Universitaire Lariboisiere-Fernand-Widal - APHP; Hopital
   Universitaire Saint-Louis - APHP; Universite Paris Cite; Universite
   Paris Cite; Institut National de la Sante et de la Recherche Medicale
   (Inserm); Institut National de la Sante et de la Recherche Medicale
   (Inserm); Universite Paris-Est-Creteil-Val-de-Marne (UPEC); Sorbonne
   Universite; Institut National de la Sante et de la Recherche Medicale
   (Inserm); Sorbonne Universite; Institut National de la Sante et de la
   Recherche Medicale (Inserm); Universite Paris-Est-Creteil-Val-de-Marne
   (UPEC); Universite Paris-Est-Creteil-Val-de-Marne (UPEC); Assistance
   Publique Hopitaux Paris (APHP); Hopital Universitaire Henri-Mondor -
   APHP; Pasteur Network; Universite Paris Cite; Institut Pasteur Paris;
   Aix-Marseille Universite; Assistance Publique-Hopitaux de Marseille;
   Aix-Marseille Universite; Centre National de la Recherche Scientifique
   (CNRS); CNRS - National Institute for Biology (INSB); CHU Grenoble
   Alpes; Communaute Universite Grenoble Alpes; Universite Grenoble Alpes
   (UGA); Institut National de la Sante et de la Recherche Medicale
   (Inserm); Universite de Montpellier; CHU de Montpellier; Universite de
   Lorraine; CHU de Nancy; Universite Paris Saclay; Centre Hospitalier de
   Versailles
RP Geoffroy, PA (corresponding author), Pr Bellivier Hop Fernand Widal, Serv Psychiat Adulte, 200 Rue Faubourg St Denis, F-75475 Paris 10, France.
EM pierre.a.geoffroy@gmail.com
RI Leboyer, Marion/AAW-3648-2021; Etain, Bruno/L-6647-2017; Geoffroy,
   Pierre Alexis/D-9743-2011
OI Etain, Bruno/0000-0002-5377-1488; LEBOYER, Marion/0000-0001-5473-3697;
   Geoffroy, Pierre Alexis/0000-0001-9121-209X
FU AstraZeneca; Lundbeck; Menarini France; Otsuka; Sanofi-Aventis; Eli
   Lilly; Bristol-Myers Squibb; Janssen Cilag; Servier; Takeda; Teva; BMS;
   Bristol-Myers-Squibb; Janssen; Foundation FondaMental; Institut National
   de la Sante et de la Recherche Medicale (INSERM); AP-HP; Investissements
   d'Avenir program
FX Dr. P.A. Geoffroy has received travel awards or financial compensation
   from AstraZeneca, Lundbeck, Menarini France and Otsuka.r Pr. C. Henry
   has received honoraria and financial compensation as independent
   symposium speaker from Sanofi-Aventis, Lundbeck, AstraZeneca, Eli Lilly,
   Bristol-Myers Squibb.r Pr. J.M. Azorin received grants/research support,
   consulting fees and honoraria within the last three years from
   AstraZeneca, Janssen Cilag, Lundbeck, Otsuka, Servier, Takeda and Teva.r
   Dr. S. Gard has received honoraria and financial compensation as
   independent symposium speaker from Astra Zeneca, BMS and Otsuka.r Pr. J.
   P. Kahn has received travel awards and honoraria or financial
   compensation as independent symposium speaker from Lundbeck,
   Bristol-Myers-Squibb, Otsuka, Janssen.r Pr. M. Leboyer has received
   honoraria and financial compensation as an independent symposium speaker
   from AstraZeneca and Servier.r Pr. F. Bellivier has received honoraria
   and financial compensation as independent symposium speaker from
   Sanofi-Aventis, Lundbeck, AstraZeneca, Eli Lilly, Bristol-Myers Squibb
   and Servier.r Ass. Pr. B. Etain has received honoraria and financial
   compensation as independent symposium speaker from Sanofi-Aventis,
   Lundbeck, AstraZeneca, Eli Lilly, Bristol-Myers Squibb and Servier.r
   This research was supported by the Foundation FondaMental, Institut
   National de la Sante et de la Recherche Medicale (INSERM), AP-HP, and by
   the Investissements d'Avenir program managed by the ANR under reference
   ANR-11-IDEX-0004-02 and ANR-10-COHO-10-01. This funding source had no
   role in the study design, data collection, analysis, preparation of the
   manuscript, or decision to submit the manuscript for publication.
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NR 66
TC 10
Z9 10
U1 0
U2 5
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 0742-0528
EI 1525-6073
J9 CHRONOBIOL INT
JI Chronobiol. Int.
PY 2017
VL 34
IS 7
BP 845
EP 854
DI 10.1080/07420528.2017.1324472
PG 10
WC Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Life Sciences & Biomedicine - Other Topics; Physiology
GA FK3AO
UT WOS:000413356500002
PM 28537802
DA 2025-06-11
ER

PT J
AU Kim, MJ
   Kim, IW
AF Kim, Mi Joung
   Kim, In Woo
TI Self-rated health may be a predictor for metabolic syndrome and high
   hs-CRP prevalences in healthy adults in South Korea: Based on the 2015
   Korea National Health and Nutrition Examination Survey
SO NUTRITION RESEARCH
LA English
DT Article
DE Self-rated health; Metabolic syndrome; hs-CRP; Healthy adults; Perceived
   stress; Self-rated health; Metabolic syndrome; hs-CRP; Healthy adults;
   Perceived stress
ID C-REACTIVE PROTEIN; INSULIN-RESISTANCE; PHYSICAL-ACTIVITY; ASSOCIATION;
   POPULATION; MORTALITY; OBESITY; RISK; INTERVENTIONS; OVERWEIGHT
AB Self-rated health (SRH), affected by sociodemographic and health-related behavioral factors, is related to metabolic syndrome (MetS) and high-sensitivity C-reactive protein (hs-CRP) levels. We hypothesized that SRH would have an independent effect on MetS and high hs-CRP incidence in healthy adults after adjusting for sociodemographic and health-related behavioral confounding factors. Data of 1545 healthy participants (aged 19-65 years; 654 men), selected from the 2015 Korean National Health and Nutritional Examination Survey, were cross-sectionally analyzed. The SRH levels significantly increased with higher income ( P < .05) and educational levels ( P < .01) and were associated with sex, job, marital status, smoking, physical activity, perceived body image, and weight change (all P < .05). The percentage of participants with "very high or high" perceived stress were significantly lower in the "very healthy" group (18.5%) than in the "unhealthy" group (49.7%). Dietary protein, calcium, and phosphorus intakes were significantly higher with better SRH levels. MetS prevalence was related to sex, educational level, job, marital status, smoking, high-intensity exercise, and aerobic exercise (all P < .05), with a 2.776 times higher risk in the "unhealthy" than in the "very healthy" group after adjusting for these confounders. High hs-CRP levels were related to marital status, smoking, weekly walking, and aerobic exercise (all P < .05), with its risk being 2.093 times higher in the "unhealthy" than in the "very healthy" group after adjusting for these confounders. Thus, SRH may be an independent predictor of MetS and high hsCRP levels and could be used for the development of a health promotion program in healthy adults.
C1 [Kim, Mi Joung; Kim, In Woo] Seoul Womens Univ, Coll Nat Sci, Dept Food & Nutr, Seoul, South Korea.
   [Kim, Mi Joung] Seoul Womens Univ, Coll Nat Sci, Dept Food & Nutr, 621 Hwarang Ro, Seoul 01797, South Korea.
C3 Seoul Women's University; Seoul Women's University
RP Kim, MJ (corresponding author), Seoul Womens Univ, Coll Nat Sci, Dept Food & Nutr, 621 Hwarang Ro, Seoul 01797, South Korea.
EM kmjoung@swu.ac.kr
RI Kim, Jong/G-7779-2012
CR Af Sillén U, 2005, SCAND J PUBLIC HEALT, V33, P183, DOI 10.1080/14034940410019235
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NR 44
TC 1
Z9 1
U1 0
U2 2
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0271-5317
EI 1879-0739
J9 NUTR RES
JI Nutr. Res.
PD JUN
PY 2022
VL 102
BP 71
EP 83
DI 10.1016/j.nutres.2022.03.003
EA APR 2022
PG 13
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nutrition & Dietetics
GA 1J1WW
UT WOS:000797715500001
PM 35436679
DA 2025-06-11
ER

PT J
AU Ohnishi, T
   Bandow, K
   Kakimoto, K
   Machigashira, M
   Matsuyama, T
   Matsuguchi, T
AF Ohnishi, T.
   Bandow, K.
   Kakimoto, K.
   Machigashira, M.
   Matsuyama, T.
   Matsuguchi, T.
TI Oxidative stress causes alveolar bone loss in metabolic syndrome model
   mice with type 2 diabetes
SO JOURNAL OF PERIODONTAL RESEARCH
LA English
DT Article
DE diabetes; metabolic syndrome; endothelial nitric oxide synthase;
   reactive oxygen species
ID NITRIC-OXIDE SYNTHASE; ORTHODONTIC TOOTH MOVEMENT;
   NECROSIS-FACTOR-ALPHA; PERIODONTAL-DISEASE; ENDOTHELIAL-CELLS; ADULT
   PERIODONTITIS; INSULIN-RESISTANCE; MESSENGER-RNA; COMPLICATIONS;
   HYPERTENSION
AB Alveolar bone loss is caused by a host response to periodontal pathogens, and its progression is often enhanced by systemic conditions such as insulin resistance.Alveolar bone dehiscence has been observed in KK-A(y) mice, which are metabolic syndrome model mice with type 2 diabetes. The aim of this study was to investigate inducements responsible for alveolar bone dehiscence in the KK-A(y) mice.
   The expression of endothelial nitric oxide synthase in the mandibles of mice was detected using immunohistochemical staining and the reverse transcription-polymerase chain reaction. After administration of N-acetylcysteine, an antioxidant, to KK-A(y) mice, alveolar bone loss and the expression of endothelial nitric oxide synthase protein in gingival keratinocytes and of hydrogen peroxide concentrations in plasma, were analyzed. The effect of hydrogen peroxide on endothelial nitric oxide synthase expression in keratinocytes was examined using cultured keratinocytes.
   The expression of endothelial nitric oxide synthase was decreased in gingival keratinocytes from KK-A(y) mice compared with gingival keratinocytes from control mice. Administration of N-acetylcysteine to the mice restored endothelial nitric oxide synthase expression in the gingival keratinocytes, suppressed the alveolar bone loss and decreased the hydrogen peroxide concentrations in plasma without the improvement of obesity or diabetes. In vitro, stimulation with hydrogen peroxide decreased the expression level of endothelial nitric oxide synthase in cultured keratinocytes, which was restored by the addition of N-acetylcysteine.
   Reactive oxygen species, such as hydrogen peroxide, are responsible for the alveolar bone loss accompanied by decreased endothelial nitric oxide synthase expression in KK-A(y) mice. Therefore, we propose a working hypothesis that the generation of oxidative stress is an underlying systemic condition that enhances alveolar bone loss in periodontitis occurring as a complication of diabetes.
C1 [Ohnishi, T.; Bandow, K.; Kakimoto, K.; Matsuguchi, T.] Kagoshima Univ, Grad Sch Med & Dent Sci, Dept Dev Med, Div Biochem & Mol Dent, Kagoshima 890, Japan.
   [Machigashira, M.; Matsuyama, T.] Kagoshima Univ, Grad Sch Med & Dent Sci, Dept Periodontol, Kagoshima 890, Japan.
C3 Kagoshima University; Kagoshima University
RP Matsuguchi, T (corresponding author), Kagoshima Univ, Grad Sch Med & Dent Sci, Dept Dev Med, Div Biochem & Mol Dent, 35-1 Sakuragaoka 8, Kagoshima 890, Japan.
EM tmatsugu@denta.hal.kagoshima-u.ac.jp
RI Matsuguchi, Tetsuya/HGU-0412-2022
OI Bandow, Kenjiro/0000-0002-1362-3034
FU Ministry of Education, Culture, Sports, Science and Technology of Japan
   [17591943, 14571767, 19390474]; Grants-in-Aid for Scientific Research
   [19390474, 14571767, 17591943] Funding Source: KAKEN
FX This work was supported by a grant from the Ministry of Education,
   Culture, Sports, Science and Technology of Japan (Grants 17591943,
   14571767 and 19390474).
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NR 39
TC 70
Z9 78
U1 0
U2 18
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-3484
EI 1600-0765
J9 J PERIODONTAL RES
JI J. Periodont. Res.
PD FEB
PY 2009
VL 44
IS 1
BP 43
EP 51
DI 10.1111/j.1600-0765.2007.01060.x
PG 9
WC Dentistry, Oral Surgery & Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dentistry, Oral Surgery & Medicine
GA 392MH
UT WOS:000262306300006
PM 18973548
DA 2025-06-11
ER

PT J
AU Ailanen, L
   Ruohonen, ST
   Vähätalo, LH
   Tuomainen, K
   Eerola, K
   Salomäki-Myftari, H
   Röyttä, M
   Laiho, A
   Ahotupa, M
   Gylling, H
   Savontaus, E
AF Ailanen, Liisa
   Ruohonen, Suvi T.
   Vahatalo, Laura H.
   Tuomainen, Katja
   Eerola, Kim
   Salomaki-Myftari, Henriikka
   Roytta, Matias
   Laiho, Asta
   Ahotupa, Markku
   Gylling, Helena
   Savontaus, Eriika
TI The metabolic syndrome in mice overexpressing neuropeptide Y in
   noradrenergic neurons
SO JOURNAL OF ENDOCRINOLOGY
LA English
DT Article
DE neuropeptide Y; hepatic cholesterol synthesis oxidative stress; glucose
   metabolism; type 2 diabetes NAFLD; Y1-receptor
ID FATTY LIVER-DISEASE; VLDL-TRIGLYCERIDE SECRETION; IMPAIRED
   GLUCOSE-TOLERANCE; LEU7PRO POLYMORPHISM; CHOLESTEROL-SYNTHESIS;
   PREPRONEUROPEPTIDE-Y; INSULIN SENSITIVITY; DIABETIC-PATIENTS; INDUCED
   OBESITY; NERVOUS-SYSTEM
AB A gain-of-function polymorphism in human neuropeptide Y (NPY) gene (rs16139) associates with metabolic disorders and earlier onset of type 2 diabetes (T2D). Similarly, mice overexpressing NPY in noradrenergic neurons (OE-NPYDBH) display obesity and impaired glucose metabolism. In this study, the metabolic syndrome-like phenotype was characterized and mechanisms of impaired hepatic fatty acid, cholesterol and glucose metabolism in pre-obese (2-month-old) and obese (4-7-month-old) OE-NPYDBH mice were elucidated. Susceptibility to T2D was assessed by subjecting mice to high caloric diet combined with low-dose streptozotocin. Contribution of hepatic Y1-receptor to the phenotype was studied using chronic treatment with an Y1-receptor antagonist, BIBO3304. Obese OE-NPYDBH mice displayed hepatosteatosis and hypercholesterolemia preceded by decreased fatty acid oxidation and accelerated cholesterol synthesis. Hyperinsulinemia in early obese state inhibited pyruvate- and glucose-induced hyperglycemia, and deterioration of glucose metabolism of OE-NPYDBH mice developed with aging. Furthermore, streptozotocin induced T2D only in OE-NPYDBH mice. Hepatic inflammation was not morphologically visible, but upregulated hepatic anti-inflammatory pathways and increased 8-isoprostane combined with increased serum resistin and decreased interleukin 10 pointed to increased NPY-induced oxidative stress that may predispose OE-NPYDBH mice to insulin resistance. Chronic treatment with BIBO3304 did not improve the metabolic status of OE-NPYDBH mice. Instead, downregulation of beta-1-adrenoceptors suggests indirect actions of NPY via inhibition of sympathetic nervous system. In conclusion, changes in hepatic fatty acid, cholesterol and glucose metabolism favoring energy storage contribute to the development of NPY-induced metabolic syndrome, and the effect is likely mediated by changes in sympathetic nervous system activity.
C1 [Ailanen, Liisa; Ruohonen, Suvi T.; Vahatalo, Laura H.; Tuomainen, Katja; Eerola, Kim; Salomaki-Myftari, Henriikka; Savontaus, Eriika] Univ Turku, Inst Biomed, Turku, Finland.
   [Ailanen, Liisa; Ruohonen, Suvi T.; Vahatalo, Laura H.; Tuomainen, Katja; Eerola, Kim; Salomaki-Myftari, Henriikka; Savontaus, Eriika] Univ Turku, Turku Ctr Dis Modelling, Turku, Finland.
   [Ailanen, Liisa; Salomaki-Myftari, Henriikka] Univ Turku, Drug Res Doctoral Program, Turku, Finland.
   [Roytta, Matias] Univ Turku, Dept Pathol, Turku, Finland.
   [Roytta, Matias] Turku Univ Hosp, Turku, Finland.
   [Laiho, Asta] Univ Turku, Turku Ctr Biotechnol, Turku, Finland.
   [Laiho, Asta] Abo Akad Univ, Turku, Finland.
   [Ahotupa, Markku] Univ Turku, Res Ctr Appl & Prevent Cardiovasc Med, Turku, Finland.
   [Gylling, Helena] Univ Helsinki, Dept Internal Med, Helsinki, Finland.
   [Gylling, Helena] Univ Helsinki, Cent Hosp, Helsinki, Finland.
   [Savontaus, Eriika] Turku Univ Hosp, Unit Clin Pharmacol, Turku, Finland.
C3 University of Turku; University of Turku; University of Turku;
   University of Turku; University of Turku; University of Turku; Abo
   Akademi University; University of Turku; University of Helsinki;
   University of Helsinki; Helsinki University Central Hospital; University
   of Turku
RP Savontaus, E (corresponding author), Turku Univ Hosp, Unit Clin Pharmacol, Turku, Finland.
EM eriika.savontaus@utu.fi
RI Tuomainen, Katja/AAG-4335-2019; Eerola, Kim/L-8819-2019; Ruohonen,
   Saku/MFI-3214-2025; Tuomainen, Katja/B-9286-2017
OI Tuomainen, Katja/0000-0003-3330-1670; Eerola, Kim/0000-0001-7882-2977;
   Savontaus, Eriika/0000-0003-3421-0367
FU Academy of Finland [130882/2009, 252441/2011]; Finnish Funding Agency
   for Innovation [40098/10]; State Funding for University-level Health
   Research; European Foundation for the Study of Diabetes; Finnish
   Foundation for Diabetes Research
FX This study was supported by Academy of Finland (130882/2009,
   252441/2011), the Finnish Funding Agency for Innovation (40098/10),
   State Funding for University-level Health Research, European Foundation
   for the Study of Diabetes and Finnish Foundation for Diabetes Research.
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NR 64
TC 19
Z9 20
U1 0
U2 1
PU BIOSCIENTIFICA LTD
PI BRISTOL
PA EURO HOUSE, 22 APEX COURT WOODLANDS, BRADLEY STOKE, BRISTOL BS32 4JT,
   ENGLAND
SN 0022-0795
EI 1479-6805
J9 J ENDOCRINOL
JI J. Endocrinol.
PD JUL
PY 2017
VL 234
IS 1
BP 57
EP 72
DI 10.1530/JOE-16-0223
PG 16
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA EZ8MO
UT WOS:000404980300022
PM 28468933
OA Bronze
DA 2025-06-11
ER

PT J
AU Ittichaicharoen, J
   Apaijai, N
   Tanajak, P
   Sa-nguanmoo, P
   Chattipakorn, N
   Chattipakorn, SC
AF Ittichaicharoen, Jitjiroj
   Apaijai, Nattayaporn
   Tanajak, Pongpan
   Sa-nguanmoo, Piangkwan
   Chattipakorn, Nipon
   Chattipakorn, Siriporn C.
TI Impaired mitochondria and intracellular calcium transients in the
   salivary glands of obese rats
SO APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
LA English
DT Article
DE insulin; obesity; metabolic syndrome; salivary gland function;
   mitochondria
ID DIPEPTIDYL PEPTIDASE-4 INHIBITOR; INSULIN-RECEPTOR FUNCTION; ACTIVATED
   PROTEIN-KINASE; METABOLIC SYNDROME; SJOGRENS-SYNDROME; CARDIAC-FUNCTION;
   SECRETION; AQUAPORIN-5; STRESS; FLUID
AB Long-term consumption of a high-fat diet (HFD) causes not only obese-insulin resistance, but is also associated with mitochondrial dysfunction in several organs. However, the effect of obese-insulin resistance on salivary glands has not been investigated. We hypothesized that obese-insulin resistance induced by HFD impaired salivary gland function by reducing salivation, increasing inflammation, and fibrosis, as well as impairing mitochondrial function and calcium transient signaling. Male Wistar rats (200-220 g) were fed either a ND or an HFD (n = 8/group) for 16 weeks. At the end of week 16, salivary flow rates, metabolic parameters, and plasma oxidative stress were determined. Rats were then sacrificed and submandibular glands were removed to determine inflammation, fibrosis, apoptosis, mitochondrial function and dynamics, and intracellular calcium transient signaling. Long-term consumption of an HFD caused obese-insulin resistance and increased oxidative stress, fibrosis, inflammation, and apoptosis in the salivary glands. In addition, impaired mitochondrial function, as indicated by increased mitochondrial reactive oxygen species, mitochondrial membrane depolarization, and mitochondrial swelling in salivary glands and impaired intracellular calcium regulation, as indicated by a reduced intracellular calcium transient rising rate, decay rates, and amplitude of salivary acinar cells, were observed in HFD-fed rats. However, salivary flow rate and level of aquaporin 5 protein were not different between both groups. Although HFD consumption did not affect salivation, it caused obese-insulin resistance, leading to pathophysiological alteration of salivary glands, including impaired intracellular calcium transients, increased oxidative stress and inflammation, and salivary mitochondrial dysfunction.
C1 [Ittichaicharoen, Jitjiroj; Chattipakorn, Siriporn C.] Chiang Mai Univ, Ctr Excellence Cardiac Electrophysiol Res, Fac Med,Neurophysiol Unit,Dept Oral Biol & Diagno, Fac Dent,Cardiac Electrophysiol Res & Training Ct, Chiang Mai 50200, Thailand.
   [Apaijai, Nattayaporn] Chiang Mai Univ, Ctr Excellence Cardiac Electrophysiol Res, Fac Med, Cardiac Electrophysiol Res & Training Ctr,Neuroph, Chiang Mai 50200, Thailand.
   [Tanajak, Pongpan; Sa-nguanmoo, Piangkwan; Chattipakorn, Nipon] Chiang Mai Univ, Ctr Excellence Cardiac Elect Res, Fac Med,Neurophysiol Unit, Cardiac Electrophysiol Res & Training Ctr,Dept Ph, Chiang Mai 50200, Thailand.
C3 Chiang Mai University; Chiang Mai University; Chiang Mai University
RP Chattipakorn, SC (corresponding author), Chiang Mai Univ, Ctr Excellence Cardiac Electrophysiol Res, Fac Med,Neurophysiol Unit,Dept Oral Biol & Diagno, Fac Dent,Cardiac Electrophysiol Res & Training Ct, Chiang Mai 50200, Thailand.
EM scchattipakorn@gmail.com
RI Chattipakorn, Nipon/AAJ-4049-2021; Tanajak, Pongpan/ABB-2347-2020
OI Sa-nguanmoo, Piangkwan/0000-0002-4795-8473; Chattipakorn,
   Nipon/0000-0003-3026-718X; Chattipakorn, Siriporn/0000-0003-1677-7052
FU Thailand Research Fund [TRF-BRG 5780016]; National Research Council of
   Thailand; CMU 50th Anniversary grant by Chiang Mai University
   [PHD/021/2556]; NSTDA Research Chair Grant from the National Science and
   Technology Development Agency Thailand; Chiang Mai University Center of
   Excellence Award
FX This work was supported by Thailand Research Fund grant: TRF-BRG 5780016
   (S.C.C.); the National Research Council of Thailand (S.C.C.); a CMU 50th
   Anniversary grant by Chiang Mai University (PHD/021/2556; J.I. and
   S.C.C.); a NSTDA Research Chair Grant from the National Science and
   Technology Development Agency Thailand (N.C.), and a Chiang Mai
   University Center of Excellence Award (N.C.). The authors would like to
   thank Ms. Cicely Proctor for her editorial assistance.
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NR 51
TC 13
Z9 14
U1 0
U2 12
PU CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS
PI OTTAWA
PA 65 AURIGA DR, SUITE 203, OTTAWA, ON K2E 7W6, CANADA
SN 1715-5312
EI 1715-5320
J9 APPL PHYSIOL NUTR ME
JI Appl. Physiol. Nutr. Metab.
PD APR
PY 2017
VL 42
IS 4
BP 420
EP 429
DI 10.1139/apnm-2016-0545
PG 10
WC Nutrition & Dietetics; Physiology; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics; Physiology; Sport Sciences
GA ER5KB
UT WOS:000398839400012
PM 28177730
DA 2025-06-11
ER

PT J
AU Tonello, L
   Oliveira-Silva, I
   Medeiros, AR
   Donato, ANA
   Schuch, FB
   Donath, L
   Boullosa, D
AF Tonello, Lais
   Oliveira-Silva, Iranse
   Medeiros, Andre Ricarte
   Alves Donato, Arthur Ney
   Schuch, Felipe Barreto
   Donath, Lars
   Boullosa, Daniel
TI Prediction of Depression Scores From Aerobic Fitness, Body Fatness,
   Physical Activity, and Vagal Indices in Non-exercising, Female Workers
SO FRONTIERS IN PSYCHIATRY
LA English
DT Article
DE depression; physical activity; autonomic control of HR; body
   composition; physical fitness; women
ID HEART-RATE-VARIABILITY; CARDIAC AUTONOMIC RECOVERY; CARDIORESPIRATORY
   FITNESS; BIPOLAR DISORDER; SEDENTARY BEHAVIOR; METABOLIC SYNDROME; MAJOR
   DEPRESSION; SYMPTOM SEVERITY; EXERCISE; PEOPLE
AB Background: Depression is associated with a decreased cardiorespiratory fitness, and physical activity [PA] levels, higher rates of obesity, and dysfunction in autonomic control of heart rate [HR]. However, these parameters were mostly recorded with indirect methods. Thus, the aim of the current study was to investigate the relationships between depression scores and objective measures of body fatness, autonomic indices (i.e. HRV and HRR), cardiorespiratory fitness and PA levels; and subsequently to present the best predictive models of depression scores for this population, based on these variables.
   Methods: Thirty-five non-exercising women (26-43 years; maximal oxygen consumption [VO(2)max] similar to 17.4-38.3 mL/kg/min) volunteered for participation in this study. All participants responded to the Beck Depression Inventory [DBI] and were evaluated for body mass index [BMI], percentage of body fat, sum of skinfolds, and VO(2)max. Subsequently, over four consecutive days, an orthostatic test and a submaximal exercise on a cycle ergometer were performed to record HRV and HRR, respectively. In addition, incidental PA was recorded during 5 consecutive days using accelerometers.
   Results: depression scores were related to VO(2)max (r = -0.446, p = 0.007) and the sum of skinfolds (r = 0.434, p = 0.009). Several stepwise multiple linear regression models were performed and only VO(2)max was revealed as an independent predictor of the Beck scores (beta = -0.446, R-2 = 0.199, p = 0.007).
   Conclusion: The present study revealed that VO(2)max and the sum of skinfolds were moderately related to depression scores, while VO(2)max was the only independent predictor of depression scores in female workers.
C1 [Tonello, Lais] Univ Gurupi, Educ Fis, Gurupi, Brazil.
   [Tonello, Lais; Medeiros, Andre Ricarte; Alves Donato, Arthur Ney] Univ Catolica Brasilia, Escola Saude & Med, Brasilia, DF, Brazil.
   [Oliveira-Silva, Iranse] UniEVANGEL Ctr Univ Anapolis, Educ Fis, Anapolis, Brazil.
   [Schuch, Felipe Barreto] Univ La Salle Canoas, Saude & Desenvolvimento Humano, Canoas, Brazil.
   [Donath, Lars] German Sport Univ Cologne, Dept Intervent Res Exercise Training, Cologne, Germany.
   [Boullosa, Daniel] James Cook Univ, Sport & Excercise Sci, Townsville, Qld, Australia.
C3 Universidade Catolica de Brasilia; German Sport University Cologne;
   James Cook University
RP Boullosa, D (corresponding author), James Cook Univ, Sport & Excercise Sci, Townsville, Qld, Australia.
EM daniel.boullosa@gmail.com
RI Boullosa, Daniel/U-3886-2019; Oliveira-Silva, Iranse/H-7046-2015;
   Medeiros, André/N-2438-2016; Schuch, Felipe/AAF-5028-2019; Schuch,
   Felipe/L-4620-2016
OI Schuch, Felipe/0000-0002-5190-4515; Boullosa,
   Daniel/0000-0002-8477-127X; Donath, Lars/0000-0001-6039-0141
FU ARM enjoy a PROSUP scholarship grant from CAPES; CNPQ [305131/2015-0]
FX LT and ARM enjoy a PROSUP scholarship grant from CAPES. DB enjoys a
   productivity research grant from CNPQ (305131/2015-0).
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NR 95
TC 16
Z9 16
U1 0
U2 13
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-0640
J9 FRONT PSYCHIATRY
JI Front. Psychiatry
PD APR 12
PY 2019
VL 10
AR 192
DI 10.3389/fpsyt.2019.00192
PG 9
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA HT2QN
UT WOS:000464407600002
PM 31031652
OA Green Published, Green Accepted, gold
DA 2025-06-11
ER

PT J
AU Iguacel, I
   Börnhorst, C
   Michels, N
   Breidenassel, C
   Dallongeville, J
   González-Gross, M
   Gottrand, F
   Kafatos, A
   Karaglani, E
   Kersting, M
   de Henauw, S
   Lambrinou, CP
   Mistura, L
   Molnár, D
   Nova, E
   Gunter, MJ
   Puerta, AD
   Rupérez, AI
   Widhalm, K
   Huybrechts, I
   Moreno, LA
AF Iguacel, Isabel
   Boernhorst, Claudia
   Michels, Nathalie
   Breidenassel, Christina
   Dallongeville, Jean
   Gonzalez-Gross, Marcela
   Gottrand, Frederic
   Kafatos, Anthony
   Karaglani, Eva
   Kersting, Mathilde
   Henauw, Stefaan de
   Lambrinou, Christina-Paulina
   Mistura, Lorenza
   Molnar, Denes
   Nova, Esther
   Gunter, Marc J.
   Puerta, Alejandro de la O.
   Ruperez, Azahara I.
   Widhalm, Kurt
   Huybrechts, Inge
   Moreno, Luis A.
TI Socioeconomically Disadvantaged Groups and Metabolic Syndrome in
   European Adolescents: The HELENA Study
SO JOURNAL OF ADOLESCENT HEALTH
LA English
DT Article
DE Metabolic syndrome; Socioeconomic disadvantages; Socioeconomic status;
   Obesity; adolescents; Modifiable lifestyle indicators
ID CHILDHOOD; DIETARY; HEALTH; LIFE; CHILDREN; OBESITY; DEFINITIONS;
   MULTICENTER; PREVALENCE; VALIDATION
AB Purpose: Psychosocial stressors derived from socioeconomic disadvantages in adolescents can result in higher risk of metabolic syndrome (MetS). We aimed to examine whether socioeconomic disadvantages were associated with MetS independent of lifestyle and whether there was a dose response relationship between the number of cumulated socioeconomic disadvantages and risk of MetS.
   Methods: This study included 1,037 European adolescents (aged 12.5-17.5 years). Sociodemographic variables and lifestyle were assessed by self-reported questionnaires. Disadvantaged groups included adolescents with low-educated parents, low family affluence, migrant origin, unemployed parents, and nontraditional families. MetS risk score was calculated as the sum of sex and age-specific z-scores of waist circumference, blood pressure, lipids, and insulin resistance. Linear mixed-effects models adjusted for sex, age, pubertal status, and lifestyle were used to study the association between social disadvantages and MetS risk score.
   Results: Adolescents with low-educated mothers showed a higher MetS score (.54 [.09-.98]; b estimate and 99% confidence interval) compared to those with high-educated mothers. Adolescents who accumulated more than three disadvantages (.69 [.08-1.31]) or with missing information on disadvantages (.72 [.04-1.40]) had a higher MetS risk score compared to nonsocioeconomically disadvantaged groups. Stronger associations between socioeconomic disadvantages and MetS were found in male than in female adolescents.
   Conclusions: Adolescents with low-educated mothers or with more than three socioeconomic disadvantages had a higher MetS risk, independent of lifestyle, potentially due to higher psychosocial stress exposure. Policy makers should focus on improving low-educated familiesa and more disadvantaged families' knowledge on nutrition and physical activity to help them cope better with stress. (C) 2020 Society for Adolescent Health and Medicine. All rights reserved.
C1 [Iguacel, Isabel; Ruperez, Azahara I.; Moreno, Luis A.] Univ Zaragoza, GENUD Growth Exercise Nutr & Dev Res Grp, Fac Hlth Sci, Deparment Physiatry & Nursing, Zaragoza, Spain.
   [Iguacel, Isabel; Ruperez, Azahara I.; Moreno, Luis A.] Inst Agroalimentario Aragon IA2, Zaragoza, Spain.
   [Iguacel, Isabel; Ruperez, Azahara I.; Moreno, Luis A.] Inst Invest Sanitaria Aragon IIS Aragon, Zaragoza, Spain.
   [Iguacel, Isabel; Ruperez, Azahara I.; Moreno, Luis A.] Ctr Invest Biomed Red Fisiopatol Obesidad & Nutr, Madrid, Spain.
   [Boernhorst, Claudia] Leibniz Inst Prevent Res & Epidemiol BIPS, Dept Biometry & Data Management, Bremen, Germany.
   [Michels, Nathalie; Henauw, Stefaan de; Huybrechts, Inge] Univ Ghent, Dept Publ Hlth, Ghent, Belgium.
   [Breidenassel, Christina; Kersting, Mathilde] Rhein Friedrich Wilhelms Univ Bonn, Dept Nutr Humannutr, Bonn, Germany.
   [Breidenassel, Christina; Gonzalez-Gross, Marcela] Univ Politecn Madrid, Fac Ciencias Act Fis & Deporte INEF, Dept Hlth & Human Performance, ImFine Res Grp, Madrid, Spain.
   [Dallongeville, Jean] Inst Pasteur, Dept Epidemiol & Publ Hlth, Lille, France.
   [Gonzalez-Gross, Marcela] Univ Politecn Madrid, Fac Ciencias Act Fsica & Deporte INEF, Dept Hlth & Human Performance, Madrid, Spain.
   [Gottrand, Frederic] Univ Lille2, INSERM, Fac Med, U995,IFR114, F-IFR114 Lille, France.
   [Kafatos, Anthony; Lambrinou, Christina-Paulina] Univ Crete, Prevent Med & Nutr Clin, Iraklion, Greece.
   [Karaglani, Eva] Harokopio Univ Athens, Depnt Nutr & Dietet, Athens, Greece.
   [Mistura, Lorenza] Council Agr Res & Econ, Res Ctr Food & Nutr, Rome, Italy.
   [Molnar, Denes] Univ Pecs, Dept Paediat, Pecs, Hungary.
   [Nova, Esther] Spanish Natl Res Council ICTAN CSIC, Immunonutr Grp Metab & Nutr Dept, EInstitute Food Sci Technol & Nutr, Madrid, Spain.
   [Gunter, Marc J.; Huybrechts, Inge] World Hlth Org, Int Agcy Res Canc, Lyon, France.
   [Puerta, Alejandro de la O.] Univ Granada, Dept Physiol, Fac Med, Granada, Spain.
   [Widhalm, Kurt] Univ Vienna, Dept Pediat, Vienna, Austria.
C3 University of Zaragoza; CIBER - Centro de Investigacion Biomedica en
   Red; CIBEROBN; Leibniz Association; Leibniz Institute for Prevention
   Research & Epidemiology (BIPS); Ghent University; University of Bonn;
   Universidad Politecnica de Madrid; Facultad de Ciencias de la Actividad
   Fisica del Deporte (INEF); Pasteur Network; Universite de Lille;
   Institut Pasteur Lille; Universidad Politecnica de Madrid; Institut
   National de la Sante et de la Recherche Medicale (Inserm); Universite de
   Lille; University of Crete; Harokopio University Athens; Consiglio per
   la Ricerca in Agricoltura e L'analisi Dell'economia Agraria (CREA);
   University of Pecs; Consejo Superior de Investigaciones Cientificas
   (CSIC); CSIC - Instituto de Ciencia y Tecnologia de Alimentos y
   Nutricion (ICTAN); World Health Organization; International Agency for
   Research on Cancer (IARC); University of Granada; University of Vienna
RP Iguacel, I (corresponding author), Univ Zaragoza, Zaragoza, Spain.
EM iguacel@unizar.es
RI Kengne, Andre/ABB-3696-2020; Crujeiras, Ana B/ABA-8866-2021; Gianfagna,
   Francesco/K-4561-2016; Moreno, Luis/S-1780-2019; Gunter,
   Marc/AAP-8621-2020; Molnár, Dénes/AAB-6820-2022; Iguacel Azorín,
   Isabel/ABC-7789-2021; Huybrechts, Inge/ITT-7052-2023; Michels,
   Nathalie/C-2819-2012; gottrand, frederic/G-7370-2015
OI Moreno Aznar, Luis A./0000-0003-0454-653X; Iguacel,
   Isabel/0000-0003-4242-5464; Gonzalez-Gross, Marcela/0000-0001-7757-3235;
   gottrand, frederic/0000-0002-5290-0436; Michels,
   Nathalie/0000-0002-3069-7254; De-la-O, Alejandro/0000-0002-0614-4545;
   Karaglani, Eva/0000-0001-5395-7023
FU European Community sixth RTD Framework Programme [FOOD-CT-2005-007034]
FX The HELENA Study was conducted with the financial support of the
   European Community sixth RTD Framework Programme (Contract
   FOOD-CT-2005-007034).
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NR 41
TC 12
Z9 13
U1 1
U2 13
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1054-139X
EI 1879-1972
J9 J ADOLESCENT HEALTH
JI J. Adolesc. Health
PD JAN
PY 2021
VL 68
IS 1
BP 146
EP 154
DI 10.1016/j.jadohealth.2020.05.027
PG 9
WC Psychology, Developmental; Public, Environmental & Occupational Health;
   Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Public, Environmental & Occupational Health; Pediatrics
GA PZ2DI
UT WOS:000612549900024
PM 32636143
OA Green Published, Green Accepted, Green Submitted
DA 2025-06-11
ER

PT J
AU Marycz, K
   Szlapka-Kosarzewska, J
   Geburek, F
   Kornicka-Garbowska, K
AF Marycz, Krzysztof
   Szlapka-Kosarzewska, J.
   Geburek, F.
   Kornicka-Garbowska, K.
TI Systemic Administration of Rejuvenated Adipose-Derived Mesenchymal Stem
   Cells Improves Liver Metabolism in Equine Metabolic Syndrome (EMS)- New
   Approach in Veterinary Regenerative Medicine
SO STEM CELL REVIEWS AND REPORTS
LA English
DT Article
DE Equine metabolic syndrome; Adipose derived stem cells; Liver; Cell
   therapy; Mesenchymal stem cells
ID OXIDATIVE STRESS; PHARMACOKINETICS; DIFFERENTIATION; RESVERATROL;
   PREVALENCE; MECHANISMS; AUTOPHAGY; OBESITY; HORSES; MICE
AB Equine metabolic syndrome (EMS) is characterized by adiposity, insulin dysregulation and increased risk for laminitis. Increased levels of specific liver enzymes in the peripheral blood are typical findings in horses diagnosed with EMS. Current management of EMS is based on caloric restriction and increased physical activity. However, new potential treatment options are arising such as the transplantation of autologous adipose stem cells (ASC). However, cytophysiological properties of ASC derived from EMS horses are impaired which strongly limits their therapeutic potential. We hypothesized, that in vitro pharmacotherapy of those cells with 5-azacytidine (AZA) and resveratrol (RES) before their clinical application can reverse the aged phenotype of those cells and improve clinical outcome of autologous therapy. A 9 year old Dutch Warmblood Horse used for driving, was presented with severe obesity, insulin resistance. After EMS diagnosis, the animal received three intravenous injections of autologous, AZA/RES treated ASCs at weekly intervals. The therapeutic effect was assessed by the analysis of liver specific enzymes in the blood. ASC-transplantation reduced levels of glutamate dehydrogenase (GLDH), gamma-glutamyltransferase (GGT), lactate dehydrogenase (LDH) and aspartate transaminase (AST). This case report demonstrates the therapeutic potential of this intervention for EMS as well as apt utility of autologous, rejuvenated ASC injections.
C1 [Marycz, Krzysztof; Kornicka-Garbowska, K.] Int Inst Translat Med, Jesionowa 11 St, PL-55114 Wisznia Mala, Poland.
   [Marycz, Krzysztof; Kornicka-Garbowska, K.] Univ Environm & Life Sci Wroclaw, Fac Biol & Anim Sci, Dept Expt Biol, Wroclaw, Poland.
   [Marycz, Krzysztof; Geburek, F.] Justus Liebig Univ, Dept Surg, Clin Horses, Fac Vet Med, Giessen, Germany.
C3 Wroclaw University of Environmental & Life Sciences; Justus Liebig
   University Giessen
RP Marycz, K (corresponding author), Int Inst Translat Med, Jesionowa 11 St, PL-55114 Wisznia Mala, Poland.; Marycz, K (corresponding author), Univ Environm & Life Sci Wroclaw, Fac Biol & Anim Sci, Dept Expt Biol, Wroclaw, Poland.; Marycz, K (corresponding author), Justus Liebig Univ, Dept Surg, Clin Horses, Fac Vet Med, Giessen, Germany.
EM krzysztof.marycz@upwr.edu.pl
FU National Science Centre in Poland [2016/21/B/NZ7/01111,
   2018/29/B/NZ7/02662]
FX This project was financed within the framework of a grants entitled
   "Modulation mitochondrial metabolism and dynamics and targeting DNA
   methylation of adipose derived mesenchymal stromal stem cell (ASC) using
   resveratrol and 5-azacytydin as a therapeutic strategy in the course of
   Equine metabolic syndrome (EMS)." (grant no. 2016/21/B/NZ7/01111) and
   "Inhibition of tyrosine phosphatase as a strategy to enhance insulin
   sensitivity through activation of chaperone mediated autophagy and
   amelioration of inflammation and cellular stress in the liver of
   equinemetabolic syndrome (EMS) horses." (grant no. 2018/29/B/NZ7/02662)
   financed by The National Science Centre in Poland.
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NR 51
TC 17
Z9 18
U1 0
U2 19
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 2629-3269
EI 2629-3277
J9 STEM CELL REV REP
JI Stem Cell Rev. Rep.
PD DEC
PY 2019
VL 15
IS 6
BP 842
EP 850
DI 10.1007/s12015-019-09913-3
EA OCT 2019
PG 9
WC Cell & Tissue Engineering; Cell Biology; Medicine, Research &
   Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Research & Experimental Medicine
GA KI9VU
UT WOS:000490884300001
PM 31620992
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Hua, HY
   Yang, JL
   Lin, HT
   Xi, Y
   Dai, MY
   Xu, GM
   Wang, FY
   Liu, LH
   Zhao, TQ
   Huang, J
   Gonzalez, FJ
   Liu, AM
AF Hua, Huiying
   Yang, Julin
   Lin, Hante
   Xi, Yang
   Dai, Manyun
   Xu, Gangming
   Wang, Fuyan
   Liu, Lihong
   Zhao, Tingqi
   Huang, Jing
   Gonzalez, Frank J.
   Liu, Aiming
TI PPARα-independent action against metabolic syndrome development by
   fibrates is mediated by inhibition of STAT3 signalling
SO JOURNAL OF PHARMACY AND PHARMACOLOGY
LA English
DT Article
DE fenofibrate; gemfibrozil; metabolic syndrome; PPAR alpha; STAT3
ID ACTIVATED-RECEPTOR-ALPHA; IMPROVES INSULIN SENSITIVITY; NF-KAPPA-B;
   INTRAHEPATIC CHOLESTASIS; OXIDATIVE STRESS; BODY-WEIGHT; US ADULTS;
   INFLAMMATION; FENOFIBRATE; DISRUPTION
AB Objectives Metabolic syndrome (MS) is the concurrence of at least three of five medical conditions: obesity, high blood pressure, insulin resistance, high serum triglyceride (TG) and low serum high-density lipoprotein levels. While fibrates are used to treat disorders other than the lowering serum TG, the mechanism by which fibrates decrease MS has not been established. Methods Key findings In this study, wild-type and Ppara-null mice fed a medium-fat diet (MFD) were administered gemfibrozil and fenofibrate for 3 months respectively, to explore the effect and action mechanism. In Ppara-null mice, MFD treatment increased body weight, adipose tissue, serum TG and impaired glucose tolerance. These phenotypes were attenuated in two groups treated with gemfibrozil and fenofibrate. The STAT3 pathway was activated in adipose and hepatic tissues in positive control, and inhibited in groups treated with gemfibrozil and fenofibrate. The above phenotypes and inflammation were not observed in any wild-type group. In 3T3-L1 adipogenic stem cells treated with high glucose, STAT3 knockdown greatly decreased the number of lipid droplets. Conclusions Low dose of clinical fibrates was effective against MS development independent of PPAR alpha, and this action was mediated by STAT3 signalling inhibition in adipose tissue and, to a lesser extent, in hepatic tissues.
C1 [Hua, Huiying; Lin, Hante; Xi, Yang; Dai, Manyun; Xu, Gangming; Wang, Fuyan; Liu, Lihong; Zhao, Tingqi; Huang, Jing; Liu, Aiming] Ningbo Univ, Med Sch, Ningbo 315211, Zhejiang, Peoples R China.
   [Yang, Julin] Ningbo Coll Hlth Sci, Ningbo, Zhejiang, Peoples R China.
   [Gonzalez, Frank J.] NCI, Lab Metab, NIH, Bethesda, MD 20892 USA.
C3 Ningbo University; National Institutes of Health (NIH) - USA; NIH
   National Cancer Institute (NCI)
RP Liu, AM (corresponding author), Ningbo Univ, Med Sch, Ningbo 315211, Zhejiang, Peoples R China.
EM liuaiming@nbu.edu.cn
RI Dai, Manyun/GZB-0789-2022; Gonzalez, Francisco/GWV-3999-2022; Zhou,
   Yonggang/HJJ-8642-2023
OI Gonzalez, Frank/0000-0002-7990-2140
FU Ningbo Natural Science Foundation [2018A610253, 2018A610384]; K.C. Wong
   Magna Fund in Ningbo University; National Cancer Institute Intramural
   Research Program
FX This work was supported by the Ningbo Natural Science Foundation (Grant
   Nos. 2018A610253, 2018A610384); the K.C. Wong Magna Fund in Ningbo
   University; and the National Cancer Institute Intramural Research
   Program.
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NR 48
TC 10
Z9 12
U1 1
U2 12
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-3573
EI 2042-7158
J9 J PHARM PHARMACOL
JI J. Pharm. Pharmacol.
PD DEC
PY 2018
VL 70
IS 12
BP 1630
EP 1642
DI 10.1111/jphp.13014
PG 13
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA GZ7TT
UT WOS:000449687300005
PM 30251457
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Ben Amara, N
   Tourniaire, F
   Maraninchi, M
   Attia, N
   Amiot-Carlin, MJ
   Raccah, D
   Valéro, R
   Landrier, JF
   Darmon, P
AF Ben Amara, N.
   Tourniaire, F.
   Maraninchi, M.
   Attia, N.
   Amiot-Carlin, M. J.
   Raccah, D.
   Valero, R.
   Landrier, J. F.
   Darmon, P.
TI Independent positive association of plasma β-carotene concentrations
   with adiponectin among non-diabetic obese subjects
SO EUROPEAN JOURNAL OF NUTRITION
LA English
DT Article
DE Carotenoids; Adiponectin; beta-Carotene; Lycopene; HOMA-IR
ID ARTERY RISK DEVELOPMENT; 3RD NATIONAL-HEALTH; METABOLIC SYNDROME; SERUM
   CAROTENOIDS; DIABETES-MELLITUS; ANTIOXIDANT CONCENTRATIONS;
   CARDIOVASCULAR-DISEASE; GLUCOSE-METABOLISM; OXIDATIVE STRESS; VITAMIN-E
AB Many epidemiological studies find an inverse correlation between carotenoids intake or carotenoids plasma concentrations and body mass index (BMI), insulin resistance or metabolic syndrome in the general population. However, it is not clear whether these relationships occur in obese population.
   We conducted a cross-sectional study in 108 obese non-diabetic patients.
   There was an inverse correlation between plasma levels of pro-vitamin A carotenoids (alpha-carotene, beta-carotene and beta-cryptoxanthin) and both BMI and insulin resistance (estimated by the HOMA-IR). No correlation between plasma concentrations of lycopene or lutein/zeaxanthin and BMI or insulin resistance was found. The inverse association between the three pro-vitamin A carotenoids and HOMA-IR disappeared after adjustment for BMI and waist circumference. Interestingly, we identified a positive association between concentrations of beta-carotene and adiponectin in plasma that was independent of sex, age, smoking status, BMI and waist circumference. To our knowledge, such association has never been described in obese patients.
   These results suggest the existence of a favourable effect of beta-carotene on insulin sensitivity in obese individuals that could involve a positive regulation of adiponectin, either directly or via its pro-vitamin A activity. The demonstration of the potential benefits of beta-carotene towards insulin sensitivity would open the way to dietary strategies to prevent metabolic syndrome.
C1 [Ben Amara, N.; Tourniaire, F.; Maraninchi, M.; Amiot-Carlin, M. J.; Raccah, D.; Valero, R.; Landrier, J. F.; Darmon, P.] Univ Aix Marseille, INRA, UMR 1260, F-13385 Marseille 05, France.
   [Ben Amara, N.; Tourniaire, F.; Maraninchi, M.; Amiot-Carlin, M. J.; Raccah, D.; Valero, R.; Landrier, J. F.; Darmon, P.] INSERM, UMR 1062, Nutr Obesite & Risque Thrombot, F-13385 Marseille 05, France.
   [Ben Amara, N.; Tourniaire, F.; Maraninchi, M.; Amiot-Carlin, M. J.; Raccah, D.; Valero, R.; Landrier, J. F.; Darmon, P.] Aix Marseille Univ, Fac Med, F-13385 Marseille 05, France.
   [Attia, N.] Fac Sci Bizerte, Lab Physiol Integree, Jarzouna 7021, Tunisia.
C3 INRAE; Institut National de la Sante et de la Recherche Medicale
   (Inserm); Aix-Marseille Universite; Institut National de la Sante et de
   la Recherche Medicale (Inserm); Aix-Marseille Universite; Universite de
   Carthage
RP Darmon, P (corresponding author), Univ Aix Marseille, INRA, UMR 1260, 27 Bd Jean Moulin, F-13385 Marseille 05, France.
EM jean-francois.landrier@univ-amu.fr; Patrice.DARMON@ap-hm.fr
RI AMIOT, MARIE/N-8894-2019; Maraninchi, Marie/M-5813-2016; Tourniaire,
   Franck/K-9131-2017; Landrier, Jean-Francois/AAH-2757-2019; AMIOT, Marie
   Josephe/M-1203-2017
OI Darmon, Patrice/0000-0003-1726-2296; Maraninchi,
   Marie/0000-0002-6645-1811; Tourniaire, Franck/0000-0002-6394-7045;
   Landrier, Jean-Francois/0000-0002-8690-8014; VALERO,
   RENE/0000-0002-2176-3280; AMIOT, Marie Josephe/0000-0003-4563-4587
FU INRA; Aix-Marseille University; AP-HM
FX The authors thank Catherine Clement, dietitian, for her expertise in
   managing and analysing the nutrition-related data. This study was
   supported by INRA, Aix-Marseille University and AP-HM.
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NR 48
TC 27
Z9 30
U1 0
U2 17
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1436-6207
EI 1436-6215
J9 EUR J NUTR
JI Eur. J. Nutr.
PD APR
PY 2015
VL 54
IS 3
BP 447
EP 454
DI 10.1007/s00394-014-0728-6
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA CE0RO
UT WOS:000351513000012
PM 24906472
DA 2025-06-11
ER

PT J
AU Imenshahidi, M
   Karimi, G
   Hosseinzadeh, H
AF Imenshahidi, Mohsen
   Karimi, Golamreza
   Hosseinzadeh, Hossein
TI Effects of melatonin on cardiovascular risk factors and metabolic
   syndrome: a comprehensive review
SO NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
LA English
DT Review
DE Cardiovascular risk factors; Melatonin; Hypertension; Diabetes; Obesity;
   Metabolic syndrome
ID ISCHEMIA-REPERFUSION INJURY; SUSTAINED-RELEASE MELATONIN; HIGH-FAT DIET;
   BLOOD-PRESSURE; ENDOTHELIAL DYSFUNCTION; MYOCARDIAL-ISCHEMIA; OXIDATIVE
   STRESS; ARTERIAL-HYPERTENSION; GLUCOSE-METABOLISM; CARDIAC INJURY
AB Melatonin, as a neuroendocrine hormone, is produced primarily by the pineal gland. Melatonin, a pleotropic molecule, acts as a free radical scavenger, antioxidant, and regulator of circadian rhythm in mammals via several receptor-mediated and non-receptor-mediated mechanisms. This inexpensive, well-tolerated, and multi-target molecule has a great therapeutic potential against many diseases. Many evidences have proposed that melatonin plays a key role in the pathophysiology of various cardiovascular diseases. The aim of this paper is to discuss the data and experiments regarding the effects of melatonin in management of cardiovascular risk factors. PubMed, EMBASE, and Scopus have been searched for data collection using related keywords. Two hundred ten articles were included in this review from 2253 founded documents. Using these documents, the main mechanisms of action of melatonin are discussed and summarized in this article. Also, recent progresses regarding melatonin's effects on cardiovascular risk factors and diseases including diabetes, hypertension, hyperlipidemia, obesity, myocardial ischemia-reperfusion injury, pulmonary hypertension, and atherosclerosis have been reviewed. Many studies have demonstrated the beneficial effects of melatonin in prevention and improving cardiovascular risk factors, and this inexpensive and well-tolerated drug can be strongly proposed in different cardiovascular diseases as well as metabolic syndrome.
C1 [Imenshahidi, Mohsen; Karimi, Golamreza; Hosseinzadeh, Hossein] Mashhad Univ Med Sci, Sch Pharm, Dept Pharmacodynam & Toxicol, Mashhad, Razavi Khorasan, Iran.
   [Imenshahidi, Mohsen; Karimi, Golamreza; Hosseinzadeh, Hossein] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Pharmaceut Res Ctr, Mashhad, Razavi Khorasan, Iran.
C3 Mashhad University of Medical Sciences; Mashhad University of Medical
   Sciences
RP Hosseinzadeh, H (corresponding author), Mashhad Univ Med Sci, Sch Pharm, Dept Pharmacodynam & Toxicol, Mashhad, Razavi Khorasan, Iran.; Hosseinzadeh, H (corresponding author), Mashhad Univ Med Sci, Pharmaceut Technol Inst, Pharmaceut Res Ctr, Mashhad, Razavi Khorasan, Iran.
EM hosseinzadehh@mums.ac.ir
RI Hosseinzadeh, Hossein/F-3013-2010
OI Hosseinzadeh, Hossein/0000-0002-3483-851X
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NR 149
TC 46
Z9 50
U1 1
U2 32
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0028-1298
EI 1432-1912
J9 N-S ARCH PHARMACOL
JI Naunyn-Schmiedebergs Arch. Pharmacol.
PD APR
PY 2020
VL 393
IS 4
BP 521
EP 536
DI 10.1007/s00210-020-01822-4
EA JAN 2020
PG 16
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA KU4GP
UT WOS:000510287600002
PM 32002576
DA 2025-06-11
ER

PT J
AU Naseri, R
   Farzaei, F
   Haratipour, P
   Nabavi, SF
   Habtemariam, S
   Farzaei, MH
   Khodarahmi, R
   Tewari, D
   Momtaz, S
AF Naseri, Rozita
   Farzaei, Fatemeh
   Haratipour, Pouya
   Nabavi, Seyed Fazel
   Habtemariam, Solomon
   Farzaei, Mohammad Hosein
   Khodarahmi, Reza
   Tewari, Devesh
   Momtaz, Saeideh
TI Anthocyanins in the Management of Metabolic Syndrome: A Pharmacological
   and Biopharmaceutical Review
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Review
DE anthocyanins; natural pigments; phytochemicals; metabolic syndrome;
   diabetes mellitus; insulin resistance
ID POMEGRANATE PUNICA-GRANATUM; ACTIVATED PROTEIN-KINASE; POLYPHENOL-RICH
   EXTRACT; OXIDATIVE STRESS; INSULIN-RESISTANCE; ANTIOXIDANT ACTIVITY;
   IN-VITRO; CARDIOVASCULAR-DISEASE; ARONIA-MELANOCARPA; NITRIC-OXIDE
AB The term "metabolic syndrome" (MetS) refers to a combination of diabetes, high blood pressure, and obesity. The origin of MetS includes a combination of multiple factors, such as sedentary lifestyle, unhealthy diet choice, and genetic factors. MetS is highly prevalent and adversely affects the general population by elevating risk of cardiovascular complications, organ failure, and much other pathology associated with late-stage diabetes. Anthocyanins (ANTs) are health-promoting bioactive compounds belonging to the flavonoids subclass of polyphenols. Numerous studies have reported the potential therapeutic benefits on MetS syndrome and diabetes from fruits rich in ANTs. This review summarizes the role of several dietary ANTs on preventing and managing MetS as well as the pharmacological mechanisms and biopharmaceutical features of their action. We also discuss potential nanoformulation and encapsulation approaches that may enhance the bioefficacy of ANTs in MetS. Experiments have demonstrated that ANTs may attenuate the symptoms of MetS via improving insulin resistance, impaired glucose tolerance, dyslipidaemia, cholesterol levels, hypertension, blood glucose, protecting beta cells, and preventing free radical production. In brief, the intake of ANT-rich supplements should be considered due to their plausible ability for prevention and management of MetS. Additionally, randomized double-blind clinical trials are obligatory for evaluating the bioefficacy and pharmacological mechanisms of ANTs and their pharmaceutical formulations in patients with MetS.
C1 [Naseri, Rozita] Kermanshah Univ Med Sci, Sch Med, Internal Med Dept, Kermanshah, Iran.
   [Farzaei, Fatemeh; Farzaei, Mohammad Hosein] Kermanshah Univ Med Sci, Pharmaceut Sci Res Ctr, Kermanshah, Iran.
   [Haratipour, Pouya] Sharif Univ Technol, Dept Chem, Tehran, Iran.
   [Haratipour, Pouya] Universal Sci Educ & Res Network, Phyto Pharmacol Interest Grp, Los Angeles, CA USA.
   [Nabavi, Seyed Fazel] Baqiyatallah Univ Med Sci, Appl Biotechnol Res Ctr, Tehran, Iran.
   [Habtemariam, Solomon] Univ Greenwich, Medway Sch Sci, Pharmacognosy Res Labs, Kent, England.
   [Khodarahmi, Reza] Kermanshah Univ Med Sci, Med Biol Res Ctr, Kermanshah, Iran.
   [Tewari, Devesh] Kumaun Univ, Fac Technol, Dept Pharmaceut Sci, Naini Tal, India.
   [Momtaz, Saeideh] ACECR, Inst Med Plants, Med Plants Res Ctr, Karaj, Iran.
   [Momtaz, Saeideh] Univ Tehran Med Sci, Inst Pharmaceut Sci, Toxicol & Dis Grp, Tehran, Iran.
C3 Kermanshah University of Medical Sciences; Kermanshah University of
   Medical Sciences; Sharif University of Technology; Baqiyatallah
   University of Medical Sciences (BMSU); University of Greenwich;
   Kermanshah University of Medical Sciences; Kumaun University; Academic
   Center for Education, Culture & Research (ACECR); Tehran University of
   Medical Sciences
RP Farzaei, MH (corresponding author), Kermanshah Univ Med Sci, Pharmaceut Sci Res Ctr, Kermanshah, Iran.; Khodarahmi, R (corresponding author), Kermanshah Univ Med Sci, Med Biol Res Ctr, Kermanshah, Iran.
EM mh.farzaei@gmail.com; rkhodarahmi@mbrc.ac.ir
RI Nabavi, Seyed Mohammad/G-5335-2010; Naseri, Rozita/M-8174-2017; Tewari,
   Devesh/P-9954-2019; Farzaei, Mohammad/M-5779-2017; Haratipour,
   Pouya/J-9454-2017; Khodarahmi, Reza/S-2685-2017; Stefanadis,
   Christodoulos/ABH-2232-2020
OI Stefanadis, Christodoulos/0000-0001-5974-6454
FU Kermanshah University of Medical Sciences
FX This work will be supported, financially, by Kermanshah University of
   Medical Sciences.
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NR 199
TC 76
Z9 83
U1 1
U2 27
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD DEC 4
PY 2018
VL 9
AR 1310
DI 10.3389/fphar.2018.01310
PG 19
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA HC8KC
UT WOS:000452050500001
PM 30564116
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Owis, AI
   Abo-Youssef, AM
   Osman, AH
AF Owis, Asmaa I.
   Abo-youssef, Amira M.
   Osman, Ahmed H.
TI Leaves of Cordia boissieri A. DC. as a potential source of
   bioactive secondary metabolites for protection against metabolic
   syndrome-induced in rats
SO ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES
LA English
DT Article
DE Cordia boissieri; metabolic syndrome; secondary metabolites
ID INSULIN-RESISTANCE; QUERCETIN; ANTIOXIDANT; FLAVONOIDS; LIVER; MODEL;
   DIET; INHIBITION; GLUCOSE; CONSTITUENTS
AB Cordia boissieri A. DC. (Boraginaceae) is traditionally used as an herbal remedy for diabetes by Hispanic women in Southwestern USA. A recent investigation showed the significant protective effect of ethyl acetate extract against metabolic syndrome (MS). However, the corresponding active principles responsible for this effect and relations between their structure and biological actions remain unclear. Thus, ethyl acetate extract was subjected to column chromatography, which yielded seven compounds identified on the basis of spectroscopic data as rutin, hesperidin, kaempferol-3O-beta-d-glucopyranoside, rosmarinic acid, beta-sitosterol-3O-beta-d-glucopyranoside, quercetin, and kaempferol. The isolated compounds (5 mg/kg/day) were tested in a fructose enriched-diet rat model using metformin as a standard drug. Blood samples were withdrawn for estimation of MS-associated biomarkers and liver samples were subjected to histopathological and immunohistochemical examination. The isolated compounds impaired most of the changes associated with MS as evidenced by improved insulin sensitivity, glucose tolerance, kidney function, lipid profiles and reduced oxidative stress and inflammation by different degrees. It is worth noting that quercetin and kaempferol showed the most potent effect. Structureactivity relationship study revealed that the presence of 2,3-double bond in ring C and ortho-hydroxylation in ring B increases the flavonoids activity while glycosylation or methylation decreased this activity.
C1 [Owis, Asmaa I.] Beni Suef Univ, Fac Pharm, Dept Pharmacognosy, Bani Suwayf, Egypt.
   [Abo-youssef, Amira M.] Beni Suef Univ, Fac Pharm, Dept Pharmacol, Bani Suwayf, Egypt.
   [Osman, Ahmed H.] Cairo Univ, Fac Vet Med, Dept Oncol, Cairo, Egypt.
C3 Egyptian Knowledge Bank (EKB); Beni Suef University; Egyptian Knowledge
   Bank (EKB); Beni Suef University; Egyptian Knowledge Bank (EKB); Cairo
   University
RP Owis, AI (corresponding author), Beni Suef Univ, Fac Pharm, Dept Pharmacognosy, Bani Suwayf, Egypt.
EM asmaa_owis@yahoo.com
RI Ismail, Asmaa/H-2385-2016
OI Abo-Youssef, Amira/0000-0001-8419-6095
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NR 46
TC 7
Z9 9
U1 0
U2 12
PU WALTER DE GRUYTER GMBH
PI BERLIN
PA GENTHINER STRASSE 13, D-10785 BERLIN, GERMANY
SN 0939-5075
EI 1865-7125
J9 Z NATURFORSCH C
JI Z.Naturforsch.(C)
PD MAR
PY 2017
VL 72
IS 3-4
BP 107
EP 118
DI 10.1515/znc-2016-0073
PG 12
WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
GA EO1LA
UT WOS:000396458800004
PM 27701140
DA 2025-06-11
ER

PT J
AU Huang, JY
   Chiang, MT
   Yet, SF
   Chau, LY
AF Huang, Jun-Yuan
   Chiang, Ming-Tsai
   Yet, Shaw-Fang
   Chau, Lee-Young
TI Myeloid Heme Oxygenase-1 Haploinsufficiency Reduces High Fat
   Diet-Induced Insulin Resistance by Affecting Adipose Macrophage
   Infiltration in Mice
SO PLOS ONE
LA English
DT Article
ID FOCAL ADHESION KINASE; CARBON-MONOXIDE; METABOLIC SYNDROME; PPAR-GAMMA;
   IN-VIVO; OBESITY; TISSUE; SENSITIVITY; ANGIOGENESIS; ACTIVATION
AB Increased adipose tissue macrophages contribute to obesity-induced metabolic syndrome. Heme oxygenase-1 (HO-1) is a stress-inducible enzyme with potent anti-inflammatory and proangiogenic activities in macrophages. However, the role of macrophage HO-1 on obesity-induced adipose inflammation and metabolic syndrome remains unclear. Here we show that high-fat diet (HFD) feeding in C57BL/6J mice induced HO-1 expression in the visceral adipose tissue, particularly the stromal vascular fraction. When the irradiated C57BL/6J mice reconstituted with wild-type or HO-1(+/-) bone marrow were fed with HFD for over 24 weeks, the HO-1(+/-) chimeras were protected from HFD-induced insulin resistance and this was associated with reduced adipose macrophage infiltration and angiogenesis, suggesting that HO-1 affects myeloid cell migration toward adipose tissue during obesity. In vivo and in vitro migration assays revealed that HO-1(+/-) macrophages exhibited an impaired migration response. Chemoattractant-induced phosphorylation of p38 and focal adhesion kinase (FAK) declined faster in HO-1(+/-) macrophages. Further experiments demonstrated that carbon monoxide and bilirubin, the byproducts derived from heme degradation by HO-1, enhanced macrophage migration by increasing phosphorylation of p38 and FAK, respectively. These data disclose a novel role of hematopoietic cell HO-1 in promoting adipose macrophage infiltration and the development of insulin resistance during obesity.
C1 [Huang, Jun-Yuan; Chau, Lee-Young] Natl Def Med Ctr, Grad Inst Life Sci, Taipei, Taiwan.
   [Huang, Jun-Yuan; Chiang, Ming-Tsai; Chau, Lee-Young] Acad Sinica, Inst Biomed Sci, Taipei, Taiwan.
   [Yet, Shaw-Fang] Natl Hlth Res Inst, Zhunan, Taiwan.
C3 National Defense Medical Center; Academia Sinica - Taiwan; National
   Health Research Institutes - Taiwan
RP Huang, JY (corresponding author), Natl Def Med Ctr, Grad Inst Life Sci, Taipei, Taiwan.
EM lyc@ibms.sinica.edu.tw
RI Chau, Lee-Young/N-7659-2018; Yet, Shaw-Fang/B-1067-2010
OI Yet, Shaw-Fang/0000-0001-9097-3962
FU National Science Council of Taiwan [NSC-97-2320-B-001-010-MY3]; National
   Research Program for Genomic Medicine at the National Science Council of
   Taiwan [NSC97-3112-B001-025]
FX This work was supported by a grant from the National Science Council of
   Taiwan (NSC-97-2320-B-001-010-MY3) (URL://web1.nsc.gov.tw). The funder
   had no role in study design, data collection and analysis, decision to
   publish, or preparation of the manuscript.We thank the Taiwan Mouse
   Clinic Core (NSC97-3112-B001-025) funded by the National Research
   Program for Genomic Medicine at the National Science Council of Taiwan
   for technical support.
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NR 52
TC 29
Z9 32
U1 0
U2 3
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JUN 21
PY 2012
VL 7
IS 6
AR e38626
DI 10.1371/journal.pone.0038626
PG 17
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 964KY
UT WOS:000305695100012
PM 22761690
OA Green Submitted, gold, Green Published
DA 2025-06-11
ER

PT J
AU Rao, Y
   Lu, YT
   Li, C
   Song, QQ
   Xu, YH
   Xu, Z
   Hu, YT
   Yu, H
   Gao, L
   Gu, LQ
   Ye, JM
   Huang, ZS
AF Rao, Yong
   Lu, Yu-Ting
   Li, Chan
   Song, Qin-Qin
   Xu, Yao-Hao
   Xu, Zhao
   Hu, Yu-Tao
   Yu, Hong
   Gao, Lin
   Gu, Lian-Quan
   Ye, Ji-Ming
   Huang, Zhi-Shu
TI Bouchardatine analogue alleviates non-alcoholic hepatic fatty liver
   disease/non-alcoholic steatohepatitis in high-fat fed mice by inhibiting
   ATP synthase activity
SO BRITISH JOURNAL OF PHARMACOLOGY
LA English
DT Article
ID ENDOPLASMIC-RETICULUM STRESS; INSULIN-RESISTANCE; OXIDATIVE STRESS;
   CONCISE GUIDE; AMPK; PHARMACOLOGY; KINASE; PATHOGENESIS; LIPOGENESIS;
   MACROPHAGE
AB Background and Purpose Non-alcoholic hepatic fatty liver disease (NAFLD) is a manifestation of the metabolic syndrome in the liver and non-alcoholic steatohepatitis (NASH) represents its advanced stage. R17 derived from bouchardatine, shows benefits in the metabolic syndrome, but has not been tested in the liver. The present study examined the pharmacological effects of R17 in a model of NAFLD/NASH and its mode of action. Experimental Approach The effects of R17 were examined in mice fed a high-fat (HF) diet to induce the pathological characteristics of NAFLD/NASH and in cultures of HuH7 cells. We used histological and immunohistochemical techniques along with western blotting and siRNA. Generation of ROS and apoptosis were measured. Key Results Administration of R17 (20 mg center dot kg(-1), i.p. every other day) for 5 weeks reversed HF-induced hepatic triglyceride content, inflammation (inflammatory cytokines and macrophage numbers), injury (hepatocyte ballooning and apoptosis, plasma levels of alanine aminotransferase and aspartate aminotransferase), and fibrogenesis (collagen deposition and mRNA expression of fibrosis markers). In cultured cells, R17 reduced cell steatosis from both lipogenesis and fatty acid influx. The attenuated inflammation and cell injury were associated with inhibition of both endoplasmic reticulum (ER) stress and oxidative stress. Notably, R17 activated the liver kinase B1-AMP-activated protein kinase (AMPK) pathway by inhibiting activity of ATP synthase, rather than direct stimulation of AMPK. Conclusion and Implications R17 has therapeutic potential for NAFLD/NASH. Its mode of action involves the elimination of ER and oxidative stresses, possibly via activating the LKB1-AMPK axis by inhibiting the activity of ATP synthase.
C1 [Rao, Yong; Lu, Yu-Ting; Li, Chan; Song, Qin-Qin; Xu, Yao-Hao; Xu, Zhao; Hu, Yu-Tao; Yu, Hong; Gao, Lin; Gu, Lian-Quan; Huang, Zhi-Shu] Sun Yat Sen Univ, Sch Pharmaceut Sci, Inst Med Chem, Guangdong Prov Key Lab New Drug Design & Evaluat, Guangzhou 510006, Guangdong, Peoples R China.
   [Ye, Ji-Ming] RMIT Univ, Sch Hlth & Biomed Sci, Lipid Biol & Metab Dis Lab, Melbourne, Vic, Australia.
C3 Sun Yat Sen University; Royal Melbourne Institute of Technology (RMIT)
RP Rao, Y; Huang, ZS (corresponding author), Sun Yat Sen Univ, Sch Pharmaceut Sci, Inst Med Chem, Guangdong Prov Key Lab New Drug Design & Evaluat, Guangzhou 510006, Guangdong, Peoples R China.; Ye, JM (corresponding author), RMIT Univ, Sch Hlth & Biomed Sci, Bldg 202,Level 4,POB 71, Melbourne, Vic 3083, Australia.
EM raoyong0805@126.com; jiming.ye@rmil.edu.au; ceshzs@mail.sysu.edu.cn
RI Yu, Hongsheng/KYQ-5450-2024; Yutao, Hu/KBP-8586-2024; Xu,
   Yaohao/LCS-8924-2024; lu, yuting/IIS-2826-2023
OI Xu, Yao-hao/0000-0003-2406-2938; Rao, Yong/0000-0002-2559-6248
FU Bureau for Foreign Experts [SYSUPCS2014]; Local Innovative and Research
   Teams Project of Guangdong Pearl River Talents Program [2017BT01Y093];
   Guangdong Provincial Key Laboratory of Construction Foundation
   [2017B030314030]; 111 Project [B16047]; Natural Science Foundation of
   Guangdong Province [2017A030308003]; Science and Technology Program of
   Guangzhou [201704020104]; Special Fund for Science and Technology
   Development in Guangdong Province [2016A020217004]; National Natural
   Science Foundation of China [81703336, 21672265]
FX Bureau for Foreign Experts, Grant/Award Number: SYSUPCS2014; Local
   Innovative and Research Teams Project of Guangdong Pearl River Talents
   Program, Grant/Award Number: 2017BT01Y093; Guangdong Provincial Key
   Laboratory of Construction Foundation, Grant/Award Number:
   2017B030314030; 111 Project, Grant/Award Number: B16047; Natural Science
   Foundation of Guangdong Province, Grant/Award Number: 2017A030308003;
   Science and Technology Program of Guangzhou, Grant/Award Number:
   201704020104; Special Fund for Science and Technology Development in
   Guangdong Province, Grant/Award Number: 2016A020217004; National Natural
   Science Foundation of China, Grant/Award Numbers: 81703336 and 21672265
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NR 42
TC 29
Z9 29
U1 3
U2 53
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0007-1188
EI 1476-5381
J9 BRIT J PHARMACOL
JI Br. J. Pharmacol.
PD AUG
PY 2019
VL 176
IS 16
BP 2877
EP 2893
DI 10.1111/bph.14713
EA JUL 2019
PG 17
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA IJ3PN
UT WOS:000474125100001
PM 31113010
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Cristani, M
   Speciale, A
   Saija, A
   Gangemi, S
   Minciullo, PL
   Cimino, F
AF Cristani, Mariateresa
   Speciale, Antonio
   Saija, Antonella
   Gangemi, Sebastiano
   Minciullo, Paola Lucia
   Cimino, Francesco
TI Circulating Advanced Oxidation Protein Products as Oxidative Stress
   Biomarkers and Progression Mediators in Pathological Conditions Related
   to Inflammation and Immune Dysregulation
SO CURRENT MEDICINAL CHEMISTRY
LA English
DT Review
DE Advanced oxidation protein products; Biomarkers; Clinical studies;
   Oxidative stress; Myeloperoxidase; Inflammation; Immune dysregulation
ID GLYCATION END-PRODUCTS; S-NITROSYLATED PROTEINS; MULTIPLE-SCLEROSIS;
   ANTIOXIDANT STATUS; METABOLIC SYNDROME; RISK-FACTORS; CELL-DEATH;
   ALZHEIMERS-DISEASE; INSULIN-RESISTANCE; REDOX REGULATION
AB Evidence came out showing that oxidative stress has a pivotal role in development and maintenance of inflammation and aberrant immune responses. Biomarkers of oxidative stress may define the proportion of oxidative damage underlying pathological conditions, and also foresee and monitor the possible efficacy of therapeutic strategies designed to control these pathologies. New compounds, which can be used as biomarkers, have been identified, and among them advanced oxidation protein products (AOPPs), formed mainly by chlorinated oxidants resulting from activity of myeloperoxidase. Our paper is aimed to review clinical evidences concerning the valuable potential of AOPPs as biomarkers of oxidative injury in development and progression of diseases and chronic conditions related to inflammatory status and immune dysregulation. These pathologies include metabolic syndrome, obesity, immune-mediated inflammatory diseases, neurodegenerative diseases, and cancer. Due to the heterogeneity of pathologies reported to be characterized by AOPP accumulation, it is evident that AOPPs are not merely a marker of neutrophil activation, but at the same time AOPPs cannot always be disease determinants. The data reported in this review corroborate the opinion that AOPPs can be successfully used to in vitro confirm the diagnosis of inflammatory and immune-mediated diseases, but at the same time evidence is that, very likely due to the way through which AOPPs are formed as well as the effect they can contribute to induce, AOPP values cannot be clearly reflective of their involvement in the pathogenesis and in the evolution of a specific disease.
C1 [Cristani, Mariateresa; Speciale, Antonio; Saija, Antonella; Cimino, Francesco] Univ Messina, Dept Chem Biol Pharmaceut & Environm Sci, Messina, Italy.
   [Gangemi, Sebastiano; Minciullo, Paola Lucia] Univ Messina, Sch & Div Allergy & Clin Immunol, Dept Clin & Expt Med, Messina, Italy.
   [Gangemi, Sebastiano] Inst Appl Sci & Intelligent Syst ISASI, Messina Unit, Messina, Italy.
C3 University of Messina; University of Messina; Consiglio Nazionale delle
   Ricerche (CNR); Istituto di Scienze Applicate e Sistemi Intelligenti
   "Eduardo Caianiello" (ISASI-CNR)
RP Minciullo, PL (corresponding author), Univ Messina, Sch & Div Allergy & Clin Immunol, Dept Clin & Expt Med, Messina, Italy.
EM pminciullo@unime.it
RI gangemi, sebastiano/GLR-3109-2022; Cimino, Francesco/C-7036-2008;
   Speciale, Antonio/C-2846-2011
OI Speciale, Antonio/0000-0002-6135-3892; Cristani,
   Mariateresa/0000-0003-4689-9616; gangemi, sebastiano/0000-0001-7001-6532
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NR 135
TC 61
Z9 63
U1 0
U2 19
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 0929-8673
EI 1875-533X
J9 CURR MED CHEM
JI Curr. Med. Chem.
PY 2016
VL 23
IS 34
BP 3862
EP 3882
DI 10.2174/0929867323666160902154748
PG 21
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Pharmacology &
   Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
GA EB0DN
UT WOS:000387013700001
PM 27593960
DA 2025-06-11
ER

PT J
AU Hsu, BG
   Lee, CJ
   Chen, YC
   Ho, GJ
   Lin, TY
   Lee, MC
AF Hsu, Bang-Gee
   Lee, Chung-Jen
   Chen, Yen-Cheng
   Ho, Guan-Jin
   Lin, Teng-Yi
   Lee, Ming-Che
TI Low serum-free oxygen radicals defense level is associated with
   peripheral arterial stiffness in kidney transplantation patients
SO INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY
LA English
DT Article
DE Kidney transplantation; free oxygen radicals testing; free oxygen
   radicals defense; arterial stiffness; brachial-ankle pulse wave velocity
ID METABOLIC SYNDROME; VASCULAR STIFFNESS; INSULIN-RESISTANCE; DEFINITION;
   RECIPIENTS; STRESS
AB Oxidative stress is a causative mechanism of vascular alterations resulting in arterial stiffness. The aim of this study was to evaluate the relationship between oxidative stress and arterial stiffness among kidney transplantation (KT) patients. Fasting blood samples were obtained from 70 KT patients. Arterial stiffness was measured by brachial-ankle pulse wave velocity. Oxidative stress was measured by free oxygen radicals testing (FORT) and free oxygen radicals defense (FORD). We found that diabetes (P = 0.005), hypertension (P = 0.001), metabolic syndrome (P = 0.029), age (P = 0.007), KT duration (P = 0.007), waist circumference (P = 0.039), systolic blood pressure (P < 0.001), diastolic blood pressure (P = 0.004), pulse pressure (P = 0.001), triglycerides (P = 0.049), fasting glucose (P = 0.003), insulin (P = 0.011), homeostasis model assessment of insulin resistance (HOMA-IR, P = 0.002), and FORT (P = 0.014) were all higher in the high arterial stiffness group, while HDL-C (P = 0.004) and FORD (P = 0.009) were lower. Multivariate logistic regression analysis of all significant variables showed that FORD level (OR: 0.849, 95% CI: 0.740-0.973, P = 0.019) is inversely associated with arterial stiffness. Logarithmically transformed HOMA-IR (beta = -0.280, P = 0.019) was independently associated with FORD levels in KT patients. Our study showed that KT patients with higher serum FORT level and lower FORD level had high arterial stiffness. Low serum FORD level is an independent predictor of peripheral arterial stiffness in KT patients. Among these KT patients, logarithmically transformed HOMA-IR is negatively associated with serum FORD level.
C1 [Hsu, Bang-Gee] Buddhist Tzu Chi Gen Hosp, Div Nephrol, Hualien, Taiwan.
   [Hsu, Bang-Gee; Chen, Yen-Cheng; Ho, Guan-Jin; Lee, Ming-Che] Tzu Chi Univ, Sch Med, Hualien, Taiwan.
   [Lee, Chung-Jen] Tzu Chi Univ Sci & Technol, Dept Nursing, Hualien, Taiwan.
   [Chen, Yen-Cheng; Ho, Guan-Jin; Lee, Ming-Che] Buddhist Tzu Chi Gen Hosp, Dept Surg, 707,Sect 3,Chung Yang Rd, Hualien, Taiwan.
   [Lin, Teng-Yi] Buddhist Tzu Chi Gen Hosp, Dept Lab Med, Hualien, Taiwan.
C3 Buddhist Tzu Chi General Hospital; Hualien Tzu Chi Hospital; Tzu Chi
   University; Tzu Chi University of Science & Technology; Buddhist Tzu Chi
   General Hospital; Hualien Tzu Chi Hospital; Buddhist Tzu Chi General
   Hospital; Hualien Tzu Chi Hospital
RP Lee, MC (corresponding author), Buddhist Tzu Chi Gen Hosp, Dept Surg, 707,Sect 3,Chung Yang Rd, Hualien, Taiwan.
EM mingche1229@gmail.com
RI Hsu, Bang-Gee/AAV-5287-2020; Lee, Ming-che/IQV-4552-2023; Lin,
   Tao/B-7256-2009
OI Lee, Chung Jen/0000-0003-1418-224X
FU Buddhist Tzu Chi General Hospital, Hualien, Taiwan [TCRD102-26]
FX This study was supported by a grant from the Buddhist Tzu Chi General
   Hospital, Hualien, Taiwan (TCRD102-26).
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NR 37
TC 0
Z9 0
U1 0
U2 2
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 1936-2625
J9 INT J CLIN EXP PATHO
JI Int. J. Clin. Exp. Pathol.
PY 2016
VL 9
IS 10
BP 10698
EP 10706
PG 9
WC Oncology; Pathology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Pathology
GA EF5WJ
UT WOS:000390400000114
DA 2025-06-11
ER

PT J
AU Soardo, G
   Donnini, D
   Domenis, L
   Catena, C
   De Silvestri, D
   Cappello, D
   Dibenedetto, A
   Carnelutti, A
   Bonasia, V
   Pagano, C
   Sechi, LA
AF Soardo, Giorgio
   Donnini, Debora
   Domenis, Liana
   Catena, Cristiana
   De Silvestri, Daniele
   Cappello, Dario
   Dibenedetto, Alessia
   Carnelutti, Alessia
   Bonasia, Vincenzo
   Pagano, Claudio
   Sechi, Leonardo A.
TI Oxidative Stress Is Activated by Free Fatty Acids in Cultured Human
   Hepatocytes
SO METABOLIC SYNDROME AND RELATED DISORDERS
LA English
DT Article
ID NONALCOHOLIC STEATOHEPATITIS; CAROTID ATHEROSCLEROSIS; PLASMA
   ADIPONECTIN; LIVER-DISEASE; VITAMIN-E; RISK; ANTIOXIDANTS; REDOX; MODEL
AB Background: Nonalcoholic fatty liver disease (NAFLD) is strongly associated to oxidative stress, metabolic syndrome, and cardiovascular risk. Hepatocytes overloaded with fatty acids (FA) could generate substances that interfere with endothelial function, providing a potential explanation for this association. We have investigated the response of cultured human hepatoblastoma cells (Hep-G2) that were exposed to FA by measuring markers of oxidative stress and thrombosis and expression of the insulin receptor.
   Methods: Hep-G2 cells were conditioned with a mixture of FA with or without N-acetyl-L-cysteine (NAC), glutathione (GSH), or adiponectin (ADN). After 7 days, we measured intracellular GSH (iGSH), nitric oxide (NO), malondialdehyde (MDA), and tissue plasminogen inhibitor-1 (PAI-1). Real-time polymerase chain reaction (PCR) was used to determine gene expression of inducible nitric oxide synthase (iNOS) and insulin receptor (INS-R).
   Results: Exposure to FA decreased iGSH and NO levels in Hep-G2 cells and increased MDA and PAI-1 production. Gene expression of iNOS and INS-R in Hep-G2 cells was decreased by exposure to FA. Co-incubation with NAC and GSH prevented the change of iNOS mRNA levels, but not of INS-R; co-incubation with ADN restored the gene expression of INS-R, but not of i-NOS. ADN prevented also the FA-induced increase in MDA in cultured human endothelial cells.
   Conclusion: Exposure to FA activates oxidative stress and production of prothrombotic markers and decreases expression of insulin receptors in cultured human hepatocytes. These effects of FA are partially prevented by ADN and might contribute to the increased cardiovascular risk in patients with NAFLD and metabolic syndrome.
C1 [Soardo, Giorgio; Donnini, Debora; Domenis, Liana; Catena, Cristiana; De Silvestri, Daniele; Cappello, Dario; Dibenedetto, Alessia; Carnelutti, Alessia; Bonasia, Vincenzo; Sechi, Leonardo A.] Univ Udine, Liver & Hypertens Unit, Dept Pathol & Expt & Clin Med, I-33100 Udine, Italy.
   [Pagano, Claudio] Univ Padua, Endocrine Metab Lab, Dept Med & Surg Sci, Padua, Italy.
C3 University of Udine; University of Padua
RP Soardo, G (corresponding author), Univ Udine, Dept Pathol & Expt & Clin Med, Liver Unit, Piazzale SM Misericordia 1, I-33100 Udine, Italy.
EM soardo.giorgio.@aoud.sanita.fvg.it
RI Sechi, Leonardo/Y-3109-2018; Pagano, Claudio/O-1873-2013
OI PAGANO, CLAUDIO/0000-0002-4335-8411; Catena,
   Cristiana/0000-0001-5039-435X
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Z9 54
U1 0
U2 14
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-4196
EI 1557-8518
J9 METAB SYNDR RELAT D
JI Metab. Syndr. Relat. Disord.
PD OCT
PY 2011
VL 9
IS 5
BP 397
EP 401
DI 10.1089/met.2010.0140
PG 5
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 827AN
UT WOS:000295397200010
PM 21561340
DA 2025-06-11
ER

PT J
AU Rakha, A
   Ramzan, Z
   Umar, N
   Rasheed, H
   Fatima, A
   Ahmed, Z
   Kieliszek, M
   Aadil, RM
AF Rakha, Allah
   Ramzan, Zunaira
   Umar, Nehal
   Rasheed, Hina
   Fatima, Aneela
   Ahmed, Zahoor
   Kieliszek, Marek
   Aadil, Rana Muhammad
TI The Role of Ashwagandha in Metabolic Syndrome: A Review of Traditional
   Knowledge and Recent Research Findings
SO JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
LA English
DT Review
DE Withania somnifera; Ashwagandha; withanolides; cardiovascular disorders;
   diabetes; metabolic syndrome
ID WITHANIA-SOMNIFERA ROOT; INSULIN-RESISTANCE; DIABETES-MELLITUS;
   OXIDATIVE STRESS; HYPERLIPIDEMIA; WITHANOLIDES; DYSFUNCTION; INSIGHTS
AB Metabolic syndrome (MetS) is a multifactorial disorder characterized by insulin resistance, dyslipidemia, central obesity, and hypertension, leading to an increased risk of cardiovascular diseases and type-2 diabetes. Although conventional drugs have been used to treat MetS and its associated complications, they are often linked with undesirable side effects. Consequently, there is a growing interest in herbal remedies as potential alternatives. Among these remedies is Withania somnifera, commonly known as Ashwagandha, a revered medicinal herb in traditional Chinese medicine and Ayurveda due to its numerous healthpromoting properties. Withanolides, such as withaferin-A and withanolid-D, are the primary active compounds in W. somnifera and suggested to play a pivotal role in managing MetS. Moreover, Ashwagandha exhibits hypotensive, anti-obesity, anti-diabetic, and anti-hyperlipidemic properties, influencing multiple molecular and cellular pathways associated with MetS. W. somnifera has been demonstrated its potential to considerably reduce atherosclerotic plaque formation, as well as lower levels of very low-density lipoprotein (VLDL), triglycerides (TG), and low-density lipoproteins (LDL). This comprehensive review provides valuable insights into the latest research findings on the preventive potential of W. somnifera against MetS. Furthermore, recent studies on Ashwagandha highlight the need for additional clinical trials to evaluate its optimal dosage, safety profile, efficacy, and precise mechanisms of action.
C1 [Rakha, Allah; Ramzan, Zunaira; Umar, Nehal; Rasheed, Hina; Aadil, Rana Muhammad] Univ Agr Faisalabad, Natl Inst Food Sci & Technol, Faisalabad 38000, Pakistan.
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C3 University of Agriculture Faisalabad; PCSIR Laboratories Complex;
   Jiangsu University; Warsaw University of Life Sciences
RP Aadil, RM (corresponding author), Univ Agr Faisalabad, Natl Inst Food Sci & Technol, Faisalabad 38000, Pakistan.
EM muhammad.aadil@uaf.edu.pk
RI Aadil, Rana Muhammad/GRY-2404-2022; Ahmad, Zahoor/AAB-3522-2021;
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OI Kieliszek, Marek/0000-0002-5836-4865
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NR 103
TC 6
Z9 6
U1 2
U2 9
PU Asia Pacific Acad Science Pte. Ltd.
PI SINGAPORE
PA 16 COLLYER QUAY #12-01 INCOME AT RAFFLES SINGAPORE, SINGAPORE, SINGAPORE
SN 0393-974X
EI 1724-6083
J9 J BIOL REG HOMEOS AG
JI J. Biol. Regul. Homeost. Agents
PD SEP
PY 2023
VL 37
IS 10
BP 5091
EP 5103
DI 10.23812/j.biol.regul.homeost.agents.20233710.494
PG 13
WC Endocrinology & Metabolism; Immunology; Medicine, Research &
   Experimental; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Immunology; Research & Experimental
   Medicine; Physiology
GA X4BK6
UT WOS:001097921100001
DA 2025-06-11
ER

PT J
AU Xu, J
   Peng, Y
   Zeng, Y
   Hua, YQ
   Xu, XL
AF Xu, Jin
   Peng, Yi
   Zeng, Yi
   Hua, Yi-qiao
   Xu, Xiao-le
TI 2, 3, 4′, 5-tetrahydroxystilbene-2-0-β-d Glycoside Attenuates Age- and
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   Receptor Knockout Mice and Its Possible Mechanisms
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE nonalcoholic steatohepatitis; atherosclerosis; metabolic syndrome
ID TETRAHYDROXYSTILBENE GLUCOSIDE; HEPATIC STEATOSIS; CHOLESTEROL;
   PATHOGENESIS; METHIONINE; MODEL
AB The compound, 2,3,5,4 '-tetrahydroxystilbene-2-O-beta-d-glucoside (TSG), a primary bioactive polyphenolic component of Polygonum multiflorum exerts numerous pharmacological activities. However, its protective effect against non-alcoholic steatohepatitis (NASH), in the context of metabolic syndrome, remains poorly understood. The aim of the present study is to evaluate the effects of TSG treatment on middle-aged (12-mo-old) male LDLr-/- mice, which were fed a high fat diet for 12 weeks to induce metabolic syndrome and NASH. At the end of the experiment, the blood samples of mice were collected for determination of metabolic parameters. Liver and aorta tissues were collected for analysis, such as histology, immunofluorescence, hepatic lipid content, real-time PCR, and western blot. Our data show that TSG treatment improved the different aspects of NASH (steatosis, inflammation, and fibrosis) and atherosclerosis, as well as some of the metabolic basal characteristics. These modulatory effects of TSG are mediated, at least in part, through regulating key regulators of lipid metabolism (SREBP1c, PPAR alpha and their target genes, ABCG5 and CYP7A1), inflammation (CD68, TNF-alpha, IL-6 and ICAM), fibrosis (alpha-SMA and TNF beta) and oxidative stress (NADPH-oxidase 2/4, CYP2E1 and antioxidant enzymes). These results suggest that TSG may be a promising candidate for preventing and treating the progression of NASH.
C1 [Xu, Jin; Peng, Yi; Zeng, Yi; Hua, Yi-qiao; Xu, Xiao-le] Nantong Univ, Pharm Coll, Dept Pharmacol, Nantong 226001, Peoples R China.
C3 Nantong University
RP Xu, XL (corresponding author), Nantong Univ, Pharm Coll, Dept Pharmacol, Nantong 226001, Peoples R China.
EM xjntu2603@126.com; bennym@163.com; yizeng668@aliyun.com;
   hyq971112@163.com; xiaolexu@ntu.edu.cn
FU National Science Foundation of China [81770446]; Six Talents Peak
   Project of Jiangsu Province [SWYY-022]; Nantong University Cooperative
   Innovation Program of Small Molecular Compound RD [NTU2016-1]
FX The research was supported by the National Science Foundation of China
   (Grant No. 81770446), the Six Talents Peak Project of Jiangsu Province
   (No. SWYY-022) and the Nantong University Cooperative Innovation Program
   of Small Molecular Compound R&D (NTU2016-1).
CR [Anonymous], ADV HEPATOL
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Z9 29
U1 1
U2 8
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD APR 1
PY 2019
VL 20
IS 7
AR 1617
DI 10.3390/ijms20071617
PG 14
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA HU0TP
UT WOS:000464984500008
PM 30939745
OA Green Submitted, gold, Green Published
DA 2025-06-11
ER

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TI Metabolic syndrome, inflammation and lower urinary tract symptoms:
   possible translational links
SO PROSTATE CANCER AND PROSTATIC DISEASES
LA English
DT Review
ID BENIGN PROSTATIC HYPERPLASIA; C-REACTIVE PROTEIN; OVERACTIVE BLADDER;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; VAGINAL TRAUMA; INTERLEUKIN-8;
   OBESITY; INCONTINENCE; PREVALENCE
AB BACKGROUND: Epidemiological data suggest that lower urinary tract symptoms (LUTSs) may be associated with metabolic syndrome (MetS). Inflammation has been proposed as a candidate mechanism at the crossroad between these two clinical entities. The aim of this review article is to evaluate the role of MetS-induced inflammation in the pathogenesis and progression of LUTS.
   METHODS: A systematic review was conducted using the keywords 'metabolic syndrome and lower urinary tract symptoms' within the title search engines including PubMed, Web of Science and the Cochrane Library for relevant research work published between 2000 and January 2015. The obtained literature was reviewed by the primary author (QH) and was assessed for eligibility and standard level of evidence.
   RESULTS: Total of 52 articles met the eligibility criteria. On the basis of database search during the past 15 years and our systematic review of prospective and retrospective cohorts, case-control trials, observational studies and animal data identified a possible link between MetS-induced inflammation and LUTS including BPH, bladder outlet obstruction, overactive bladder, urinary incontinence and other possible urinary tract abnormalities.
   CONCLUSIONS: There is convincing evidence to suggest that MetS and inflammation could be important contributors to LUTS in men, particularly in the development of BPH. However, the role of MetS-induced inflammation remains unclear in overactive bladder, urinary incontinence and etiology of LUTS progression.
C1 [He, Q.; Gupta, S.] Case Western Reserve Univ, Dept Urol, 10900 Euclid Ave, Cleveland, OH 44106 USA.
   [He, Q.; MacLennan, G. T.; Gupta, S.] Univ Hosp, Case Med Ctr, 10900 Euclid Ave, Cleveland, OH 44106 USA.
   [He, Q.; Wang, Z.] Lanzhou Univ, Dept Urol, Key Lab Dis Urol Syst, Gansu Nephrourol Clin Ctr,Hosp 2, Lanzhou 730000, Gansu, Peoples R China.
   [Liu, G.; Daneshgari, F.] Case Western Reserve Univ, Dept Surg, MetroHealth Med Ctr, Cleveland, OH 44106 USA.
   [MacLennan, G. T.] Case Western Reserve Univ, Dept Pathol, Cleveland, OH 44106 USA.
C3 University System of Ohio; Case Western Reserve University; University
   System of Ohio; Case Western Reserve University; University Hospitals of
   Cleveland; Lanzhou University; University System of Ohio; Case Western
   Reserve University; MetroHealth System; University System of Ohio; Case
   Western Reserve University
RP Gupta, S (corresponding author), Case Western Reserve Univ, Dept Urol, 10900 Euclid Ave, Cleveland, OH 44106 USA.; Gupta, S (corresponding author), Univ Hosp, Case Med Ctr, 10900 Euclid Ave, Cleveland, OH 44106 USA.
EM sanjay.gupta@case.edu
RI Liu, Guiming/AAM-2688-2020
OI MacLennan, Gregory T./0000-0003-0089-449X; Gupta,
   Sanjay/0000-0002-9492-3249
FU United States Public Health Services [P20DK090871]; China Scholarship
   Council [201306180078]
FX We apologize to those investigators whose original work could not be
   cited owing to the space limitation. The original work cited in this
   review was supported by grants from United States Public Health Services
   P20DK090871 and 201306180078 from China Scholarship Council.
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NR 81
TC 64
Z9 71
U1 2
U2 18
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 1365-7852
EI 1476-5608
J9 PROSTATE CANCER P D
JI Prostate Cancer Prostatic Dis.
PD MAR
PY 2016
VL 19
IS 1
BP 7
EP 13
DI 10.1038/pcan.2015.43
PG 7
WC Oncology; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Urology & Nephrology
GA DD3IT
UT WOS:000369816300002
PM 26391088
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Mohsenpour, MA
   Mohammadi, F
   Razmjooei, N
   Eftekhari, MH
   Hejazi, N
AF Mohsenpour, Mohammad Ali
   Mohammadi, Farzaneh
   Razmjooei, Nadia
   Eftekhari, Mohammad Hassan
   Hejazi, Najmeh
TI Milk kefir drink may not reduce depression in patients with
   non-alcoholic fatty liver disease: secondary outcome analysis of a
   randomized, single-blinded, controlled clinical trial
SO BMC NUTRITION
LA English
DT Article
DE Non-alcoholic fatty liver disease; Depression; Depressive disorder;
   Milk; Kefir
ID METABOLIC SYNDROME; ASSOCIATIONS; CONSUMPTION; DISORDER; YOGURT
AB BackgroundDepression is prevalent among individuals with non-alcoholic fatty liver disease (NAFLD) and can cause poor health outcomes. Moreover, a solid bilateral association between NAFLD and depression has been shown, which may alleviate by kefir consumption. Thus, we aimed to investigate the effect of milk kefir drinks on the depression status of individuals with NAFLD.MethodsIn a secondary outcome analysis of a randomized, single-blinded, controlled clinical trial, 80 adults with grades 1 to 3 of NAFLD were included in an 8-week intervention. Participants were randomly assigned to Diet or Diet + kefir groups to either follow a low-calorie diet or a low-calorie diet along with a 500 cc milk kefir drink daily. The participants' demographic, anthropometric, dietary, and physical data were recorded before and after the study. Depression status was assessed using the Persian format of the second version of the Beck Depression Inventory (BDI-II-Persian) at the baseline and after 8 weeks of intervention.ResultsOverall, 80 participants aged 42.87 & PLUSMN; 10.67 years were included in the analysis. The data on the baseline demographic, dietary, and physical activity of the groups were not significantly different. During the study, participants in Diet + Kefir group had a significantly decreased energy (P = 0.02), carbohydrate (P = 0.4), and fat consumption (P = 0.4). However, during the study, the depression score was not significantly reduced in the Diet group, the Diet + Kefir group showed a significant reduction in depression (P = 0.02). However, between-group analyses for changes in depression were not significant (P = 0.59).ConclusionConsumption of milk kefir drink for 8 weeks may not reduce depression symptoms in adults with NAFLD.
C1 [Mohsenpour, Mohammad Ali; Mohammadi, Farzaneh] Shiraz Univ Med Sci, Student Res Comm, Shiraz, Iran.
   [Mohsenpour, Mohammad Ali; Mohammadi, Farzaneh; Razmjooei, Nadia; Eftekhari, Mohammad Hassan; Hejazi, Najmeh] Shiraz Univ Med Sci, Sch Nutr & Food Sci, Dept Clin Nutr, Shiraz, Iran.
C3 Shiraz University of Medical Science; Shiraz University of Medical
   Science
RP Hejazi, N (corresponding author), Shiraz Univ Med Sci, Sch Nutr & Food Sci, Dept Clin Nutr, Shiraz, Iran.
EM najmehhejazi@gmail.com
RI Mohsenpour, Mohammad Ali/GYA-4997-2022; Hejazi, Najmeh/R-4345-2017;
   Mohammadi, Farzaneh/IYJ-7537-2023
OI Mohsenpour, Mohammad Ali/0000-0001-6885-1993; Mohammadi,
   Farzaneh/0000-0002-0088-4729
FU Shiraz University of Medical Sciences
FX The Authors send warm regards to the participants of the study. The
   research team would like to thank the staff of Motahari Clinic for their
   cooperation and the vice-chancellor for research of Shiraz University of
   Medical Sciences for financial support of the study. The authors would
   like to thank Shiraz University of Medical Sciences, Shiraz, Iran and
   also Center for Development of Clinical Research of Nemazee Hospital and
   Dr. Nasrin Shokrpour for editorial assistance.
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NR 43
TC 5
Z9 5
U1 0
U2 5
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 2055-0928
J9 BMC NUTR
JI BMC Nutr.
PD JUN 29
PY 2023
VL 9
IS 1
AR 80
DI 10.1186/s40795-023-00732-x
PG 9
WC Nutrition & Dietetics
WE Emerging Sources Citation Index (ESCI)
SC Nutrition & Dietetics
GA L1RQ0
UT WOS:001021102200002
PM 37386551
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Stranahan, AM
   Mattson, MP
AF Stranahan, Alexis M.
   Mattson, Mark P.
TI Recruiting adaptive cellular stress responses for successful brain
   ageing
SO NATURE REVIEWS NEUROSCIENCE
LA English
DT Review
ID BODY-MASS INDEX; HIPPOCAMPAL OXIDATIVE STRESS; HIGH-FAT DIET;
   NEUROTROPHIC FACTOR; COGNITIVE DECLINE; SYNAPTIC PLASTICITY; BEHAVIORAL
   DEFICITS; LIPID-PEROXIDATION; METABOLIC SYNDROME; IMPROVES MEMORY
AB Successful ageing is determined in part by genetic background, but also by experiential factors associated with lifestyle and culture. Dietary, behavioural and pharmacological interventions have been identified as potential means to slow brain ageing and forestall neurodegenerative disease. Many of these interventions recruit adaptive cellular stress responses to strengthen neuronal networks and enhance plasticity. In this Science and Society article, we describe several determinants of healthy and pathological brain ageing, with insights into how these processes are accelerated or prevented. We also describe the mechanisms underlying the neuroprotective actions of exercise and nutritional interventions, with the goal of recruiting these molecular targets for the treatment and prevention of neurodegenerative disease.
C1 [Mattson, Mark P.] NIH, Neurosci Lab, Natl Inst Ageing Intramural Res Program, Baltimore, MD 21224 USA.
   [Stranahan, Alexis M.] Georgia Hlth Sci Univ, Dept Physiol, Augusta, GA 30912 USA.
C3 National Institutes of Health (NIH) - USA; NIH National Institute on
   Aging (NIA); University System of Georgia; Augusta University
RP Mattson, MP (corresponding author), NIH, Neurosci Lab, Natl Inst Ageing Intramural Res Program, Baltimore, MD 21224 USA.
EM mattsonm@grc.nia.nih.gov
RI Stranahan, Alexis/AAF-3559-2020; Mattson, Mark/F-6038-2012
FU National Institute on Aging
FX This work was supported by the Intramural Research Program of the
   National Institute on Aging.
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NR 95
TC 124
Z9 145
U1 0
U2 39
PU NATURE RESEARCH
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 1471-003X
EI 1471-0048
J9 NAT REV NEUROSCI
JI Nat. Rev. Neurosci.
PD MAR
PY 2012
VL 13
IS 3
BP 209
EP 216
DI 10.1038/nrn3151
PG 8
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 897GR
UT WOS:000300636500014
PM 22251954
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Lin, Y
   Ni, XY
   Zhu, L
   Lin, YL
   Peng, C
   Lei, Z
   Wang, YH
   Wang, H
   You, X
   Li, J
   Shen, HQ
   Wei, J
AF Lin, Yi
   Ni, Xiuye
   Zhu, Lin
   Lin, Yilong
   Peng, Cai
   Lei, Zhao
   Wang, Yihui
   Wang, Huan
   You, Xiang
   Li, Juan
   Shen, Heqing
   Wei, Jie
TI Multi-miRNAs-Mediated Hepatic Lepr Axis Suppression: A Pparg-Dicer1
   Pathway-Driven Mechanism in Spermatogenesis for the Intergenerational
   Transmission of Paternal Metabolic Syndrome
SO ADVANCED SCIENCE
LA English
DT Article
DE bisphenol A; intergenerational transmission; leptin resistance;
   metabolic syndrome; microRNAs
ID NONALCOHOLIC FATTY LIVER; PPAR-GAMMA; BISPHENOL-A; PERINATAL EXPOSURE;
   SPERM; EXPRESSION; REPROGRAMS; STRESS; INHERITANCE; DISORDERS
AB Bisphenol A (BPA) is an "environmental obesogen" and this study aims to investigate the intergenerational impacts of BPA-induced metabolic syndrome (MetS), specifically focusing on unraveling mechanisms. Exposure to BPA induces metabolic disorders in the paternal mice, which are then transmitted to offspring, leading to late-onset MetS. Mechanistically, BPA upregulates Srebf1, which in turn promotes the Pparg-dependent transcription of Dicer1 in spermatocytes, increasing the levels of multiple sperm microRNAs (miRNAs). Several of these miRNAs are highly expressed in a synchronized manner in liver of the offspring. miR149-5p, miR150-5p, and miR700-5p target a specific region in the Lepr 3 ' UTR, termed "SMITE" ("Several MiRNAs Targeting Elements"), to negatively regulate Lepr. These inherited anti-Lepr miRNAs, also referred to inherited anti-Lepr miRNAs (IAL-miRs), modulate hepatic steatosis, and insulin signaling through the Lepr regulatory Igfbp2, Egfr, and Ampk. Furthermore, IAL-miRs inhibit Ccnd1 not only via binding to "SMITE" but also via Lepr-Igfbp2 axis, which contribute to hepatocyte senescence. These pathological processes interact in a self-reinforcing cycle, worsening MetS in the paternal BPA-exposed offspring. The findings reveal mechanism wherein lipid metabolism reprogramming in spermatocytes-induced perturbations of sperm miRNAs, triggered by BPA, leads to intergenerational inheritance of paternal MetS through suppression of the hepatic Lepr axis in the offspring.
C1 [Lin, Yi; Ni, Xiuye; Zhu, Lin; Lei, Zhao; Wang, Yihui; Wang, Huan; Shen, Heqing] Xiamen Univ, Sch Publ Hlth, State Key Lab Vaccines Infect Dis, Xiang Biomed Lab,Natl Innovat Platform Ind Educ In, Xiamen 361102, Peoples R China.
   [Lin, Yi] Xiamen Univ, Sch Med, Dept Basic Med Sci, Xiamen 361102, Peoples R China.
   [Lin, Yilong; Peng, Cai; You, Xiang; Li, Juan; Wei, Jie] Xiamen Univ, Fujian Key Lab Coastal Pollut Prevent & Control, Xiamen 361102, Peoples R China.
C3 Xiamen University; Xiamen University; Xiamen University
RP Lin, Y; Shen, HQ (corresponding author), Xiamen Univ, Sch Publ Hlth, State Key Lab Vaccines Infect Dis, Xiang Biomed Lab,Natl Innovat Platform Ind Educ In, Xiamen 361102, Peoples R China.; Wei, J (corresponding author), Xiamen Univ, Fujian Key Lab Coastal Pollut Prevent & Control, Xiamen 361102, Peoples R China.
EM tjlinyi@xmu.edu.cn; hqshen@xmu.edu.cn; jiewei@xmu.edu.cn
RI Wang, Yihui/GQY-8908-2022
FU National Natural Science Foundation of China; Natural Science Foundation
   of Fujian [2023J01039, 2021J01012]; Scientific Research Support Program
   for Young Teachers of School of Medicine, Xiamen University; 
   [82073505];  [81502782];  [21677140];  [22076158]
FX Y.L., X.N., L.Z., and Y.L. contributed equally to this work. This work
   was supported by the National Natural Science Foundation of China
   (82073505, 81502782, 21677140, and 22076158), the Natural Science
   Foundation of Fujian (2023J01039 and 2021J01012), and the Scientific
   Research Support Program for Young Teachers of School of Medicine,
   Xiamen University. The authors thank Luming Yao and Caiming Wu in the
   School of Life Sciences, Xiamen University for their assistance in the
   preparation and imaging of the electron microscopy sample, and thank
   Jingru Huang in the School of Medicine, Xiamen University for her
   assistance in the confocal microscopy analyses.
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NR 95
TC 0
Z9 0
U1 5
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
EI 2198-3844
J9 ADV SCI
JI Adv. Sci.
PD MAR
PY 2025
VL 12
IS 9
DI 10.1002/advs.202410831
EA JAN 2025
PG 22
WC Chemistry, Multidisciplinary; Nanoscience & Nanotechnology; Materials
   Science, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Science & Technology - Other Topics; Materials Science
GA Z6U3T
UT WOS:001393597700001
PM 39792613
OA gold
DA 2025-06-11
ER

PT J
AU LaHue, SC
   Comella, CL
   Tanner, CM
AF LaHue, Sara C.
   Comella, Cynthia L.
   Tanner, Caroline M.
TI The best medicine? The influence of physical activity and inactivity on
   Parkinson's disease
SO MOVEMENT DISORDERS
LA English
DT Review
DE Parkinson's disease; exercise; metabolic syndrome; physical activity;
   disease modification
ID BODY-MASS INDEX; 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE-LESIONED
   MOUSE MODEL; RANDOMIZED CONTROLLED-TRIAL; TREADMILL EXERCISE;
   ECONOMIC-EVALUATION; METABOLIC SYNDROME; COGNITIVE DECLINE;
   SUBSTANTIA-NIGRA; REDUCED RISK; FUTURE RISK
AB The incidence of Parkinson's disease (PD) is expected to increase as our population ages and will likely strain the projected capacity of our health care system. Despite being the most common movement disorder, there have been few noninvasive therapeutic advances for people with PD since the first levodopa clinical trial in 1961. The study of PD pathogenesis, combined with an appreciation for the biochemical mechanisms by which physical activity and exercise may impact physiology, has resulted in emerging hypotheses for new modifiable risk factors for PD. Physical activity and exercise as a means of preventing PD, or maintaining the functionality of people with PD, are a promising area of investigation. Conversely, physical inactivity is implicated in many disease states, some of which are also correlated with the development of PD, such as metabolic syndrome. The primary relationship between these diseases is likely rooted in heightened inflammation and oxidative stress at the cellular level. Physical activity and exercise as a means of attenuating inflammation have led to increased interest in related potential therapeutic targets for PD. Ultimately, these findings may translate into low-cost, universally available therapies for PD disease modification or prevention. (c) 2016 International Parkinson and Movement Disorder Society
C1 [LaHue, Sara C.] Kaiser Permanente San Francisco Med Ctr, San Francisco, CA USA.
   [Comella, Cynthia L.] Rush Presbyterian St Lukes Med Ctr, Neurol Sci, Chicago, IL USA.
   [Tanner, Caroline M.] San Francisco VA Med Ctr, San Francisco, CA USA.
   [Tanner, Caroline M.] Univ Calif San Francisco, Dept Neurol, San Francisco, CA USA.
C3 Kaiser Permanente; Rush University; US Department of Veterans Affairs;
   Veterans Health Administration (VHA); San Francisco VA Medical Center;
   University of California System; University of California San Francisco
RP Tanner, CM (corresponding author), Univ Calif San Francisco, Dept Neurol, Movement Disorders & Neuromodulat Ctr, 1635 Divisadero St,Suite 515, San Francisco, CA 94115 USA.
EM caroline.tanner@ucsf.edu
FU NIH [R01NS074343, U54NS065701]; Dystonia Medical Research Foundation;
   Allergan Inc.; Impax Pharmaceuticals; Ipsen Biopharmaceuticals, Inc;
   Medtronic Inc.; Merz Pharmaceuticals; US World Meds; Acadia
   Pharmaceuticals; Teva Neurosciences; Parkinson's Disease Foundation;
   Michael J. Fox Foundation; Department of Defense; National Institutes of
   Health
FX Dr. LaHue has no disclosures. Dr. Comella serves on the editorial board
   of Clinical Neuropharmacology, Sleep Medicine, and Continuum. She
   receives research support from the NIH R01NS074343, U54NS065701,
   Dystonia Medical Research Foundation, Allergan Inc., Ipsen
   Biopharmaceuticals, Inc, and Merz Pharmaceutical. She receives
   compensation/honoraria for services as a consultant or an advisory
   committee member from Allergan, Inc, Impax Pharmaceuticals, Ipsen
   Biopharmaceuticals, Inc, Medtronic Inc., Merz Pharmaceuticals, US World
   Meds, Acadia Pharmaceuticals, and Teva Neurosciences. She receives
   royalties from Cambridge, Humana Press, and Wolters Kluwer. She receives
   research support from the Parkinson's Disease Foundation. Dr. Tanner,
   serves on the editorial boards of the Annals of Neurology, Journal of
   Parkinson's Disease, Parkinsonism and Related Disorders, and NPJ
   Parkinson's Disease. She serves on the Scientific Advisory Boards of the
   Michael J. Fox Foundation and the National Spasmodic Dysphonia
   Association as a voluntary consultant and has provided paid consulting
   services to Ultragenyx Pharmaceuticals, Neurocrine Biosciences,
   Cynapsus, and Adamas. She has received compensation for serving on Data
   Monitoring Committees from Biotie Therapeutics, Voyager Therapeutics,
   and Intec Pharma. She receives grant support from the Michael J. Fox
   Foundation, the Parkinson's Disease Foundation, the Department of
   Defense, and the National Institutes of Health.
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NR 118
TC 89
Z9 99
U1 3
U2 40
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0885-3185
EI 1531-8257
J9 MOVEMENT DISORD
JI Mov. Disord.
PD OCT
PY 2016
VL 31
IS 10
BP 1444
EP 1454
DI 10.1002/mds.26728
PG 11
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA DZ7MG
UT WOS:000386049400003
PM 27477046
OA Green Submitted, Green Accepted
DA 2025-06-11
ER

PT J
AU Martinelli, N
   Girelli, D
   Olivieri, O
   Cavallari, U
   Biscuola, M
   Trabetti, E
   Friso, S
   Pizzolo, F
   Tenuti, I
   Bozzini, C
   Villa, G
   Ceradini, B
   Sandri, M
   Cheng, S
   Grow, MA
   Pignatti, PF
   Corrocher, R
AF Martinelli, N
   Girelli, D
   Olivieri, O
   Cavallari, U
   Biscuola, M
   Trabetti, E
   Friso, S
   Pizzolo, F
   Tenuti, I
   Bozzini, C
   Villa, G
   Ceradini, B
   Sandri, M
   Cheng, S
   Grow, MA
   Pignatti, PF
   Corrocher, R
TI Interaction between metabolic syndrome and PON1 polymorphisms as a
   determinant of the risk of coronary artery disease
SO CLINICAL AND EXPERIMENTAL MEDICINE
LA English
DT Article
DE PON1 polymorphisms; metabolic syndrome; coronary artery disease
ID HUMAN PARAOXONASE GENE; LOW-DENSITY-LIPOPROTEIN; HOMEOSTASIS MODEL
   ASSESSMENT; SERUM PARAOXONASE; MYOCARDIAL-INFARCTION; HEART-DISEASE;
   GLN-ARG192 POLYMORPHISM; CARDIOVASCULAR-DISEASE; OXIDATIVE MODIFICATION;
   HUMPONA GENE
AB The enzyme serum paraoxonase plays an important role in antioxidant defences and prevention of atherosclerosis. Metabolic syndrome (MS) is a clinical condition associated with increased oxidant stress and cardiovascular mortality. Two common polymorphisms of serum paraoxonase, PON1 Leu(55)Met and Gln(192)Arg, have been postulated to modulate the cardiovascular risk. We studied 915 subjects with angiographic documentation: 642 subjects with coronary atherosclerosis and 273 with normal coronary arteries. Two hundred and twenty-four subjects met the diagnostic criteria of MS. We found a significant interaction between MS and both the PON1 polymorphisms in determining the risk of coronary artery disease (P < 0.05 by likelihood-ratio test). The 55Leu and the 192Arg alleles, associated with reduced protection against lipid peroxidation, were associated with coronary artery disease only in the MS subgroup. Subjects with MS and both 55Leu and 192Arg alleles had significantly increased risk (OR=9.38 with 95% CI=3.02-29.13 after adjustment by multiple logistic regression) as compared to subjects without MS and with 55Met/Met-192Gln/Gln genotype. No increased risk was found for subjects with MS and the 55Met/Met-192Gln/Gln genotype. This study highlights a potential example of genetic (paraoxonase polymorphisms)-clinical (MS) interaction influencing cardiovascular risk.
C1 Univ Verona, Dept Clin & Expt Med, Policlin GB Rossi, I-37134 Verona, Italy.
   Univ Verona, Dept Mother & Child & Biol Genet, Sect Biol & Genet, I-37100 Verona, Italy.
   Roche Mol Syst Inc, Dept Human Genet, Alameda, CA USA.
C3 University of Verona; Azienda Ospedaliera Universitaria Integrata
   Verona; University of Verona; Roche Holding; Roche Holding USA
RP Univ Verona, Dept Clin & Expt Med, Policlin GB Rossi, I-37134 Verona, Italy.
EM roberto.corrocher@univr.it
RI Girelli, Domenico/B-1183-2008; Friso, Simonetta/K-4715-2016; Vicente,
   Jose/C-1123-2011; Pizzolo, Francesca/AAF-6581-2020; Olivieri,
   Oliviero/A-9126-2008; Sandri, Marco/L-2875-2013; Martinelli,
   Nicola/J-5622-2016
OI Cavallari, Ugo/0000-0002-3395-4033; Sandri, Marco/0000-0002-1422-5695;
   GIRELLI, Domenico/0000-0001-9684-1899; Martinelli,
   Nicola/0000-0001-6465-5119; olivieri, oliviero/0000-0001-8209-9056
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NR 69
TC 29
Z9 31
U1 0
U2 2
PU SPRINGER-VERLAG ITALIA SRL
PI MILAN
PA VIA DECEMBRIO, 28, MILAN, 20137, ITALY
SN 1591-8890
EI 1591-9528
J9 CLIN EXP MED
JI Clin. Exper. Med.
PD MAY
PY 2005
VL 5
IS 1
BP 20
EP 30
DI 10.1007/s10238-005-0060-9
PG 11
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 931UO
UT WOS:000229511200003
PM 15928879
DA 2025-06-11
ER

PT J
AU Ciocca, G
   Carosa, E
   Stornelli, M
   Limoncin, E
   Gravina, GL
   Iannarelli, R
   Sperandio, A
   Di Sante, S
   Lenzi, A
   Lauro, D
   Jannini, EA
AF Ciocca, Giacomo
   Carosa, Eleonora
   Stornelli, Maria
   Limoncin, Erika
   Gravina, Giovanni L.
   Iannarelli, Rossella
   Sperandio, Alessandra
   Di Sante, Stefania
   Lenzi, Andrea
   Lauro, Davide
   Jannini, Emmanuele A.
TI Post-traumatic stress disorder, coping strategies and type 2 diabetes:
   psychometric assessment after L'Aquila earthquake
SO ACTA DIABETOLOGICA
LA English
DT Article
DE PTSD; Coping strategies; Type 2 diabetes; Earthquake; Psychometric
   assessment
ID DSM-IV-TR; METABOLIC SYNDROME; BRIEF COPE; DEPRESSIVE SYMPTOMS; PTSD
   PREVALENCE; MENTAL-HEALTH; SURVIVORS; VULNERABILITY; VETERANS; ILLNESS
AB After natural and collective catastrophes, many behavioral phenomena can occur through psychobiological responses that involve also the diabetic condition.The aim of this study was to investigate post-traumatic stress disorder (PTSD) and coping strategies in type 2 diabetic patients after L'Aquila earthquake, with a particular attention to the newly diagnosed patients and to the gender differences.
   Among the local diabetic population, we recruited 100 diabetic patients (46 women and 54 men). Sixty of these had diabetes before the earthquake (pre-quake patients), and other 40 received diabetes diagnosis after the earthquake (post-quake patients). A psychometric protocol composed by Davidson Trauma Scale for PTSD and Brief-COPE for coping strategies was administered.
   We found significant differences in the levels of PTSD when comparing both post-quake with pre-quake patients (post-quake = 51.72 +/- A 26.05 vs. pre-quake = 31.65 +/- A 22.59; p < 0.05) and the female patients with males (women = 53.50 +/- A 27.01 vs. men = 31.65 +/- A 23.06; p < 0.05) and also in the prevalence [post-quake = 27/40 (67.5 %) vs. pre-quake = 20/60 (33.3 %); p < 0.05], [women = 27/46 (58.69 %) vs. men = 16/54 (29.62 %); p < 0.05]. Moreover, maladaptive coping was a predictive factor for PTSD in the post-quake group only (OR 1.682; 95 % CI 1.155-2.450; p = 0.006).
   Our results revealed that PTSD may be considered an important comorbidity factor in newly diagnosed patients and in diabetic women. Hence, a psychological support seems particularly important in these patients after a collective traumatic event to help them react to both PTSD and diabetes and to help them improve their coping skills.
C1 [Ciocca, Giacomo; Carosa, Eleonora; Stornelli, Maria; Limoncin, Erika; Gravina, Giovanni L.] Univ Aquila, Dept Biotechnol & Appl Clin Sci, I-67100 Laquila, Italy.
   [Iannarelli, Rossella; Sperandio, Alessandra] San Salvatore Hosp, Unit Diabetol & Metab Dis, Laquila, Italy.
   [Di Sante, Stefania; Lenzi, Andrea] Univ Roma La Sapienza, Dept Expt Med, I-00185 Rome, Italy.
   [Lauro, Davide; Jannini, Emmanuele A.] Univ Roma Tor Vergata, Dept Syst Med, I-00131 Rome, Italy.
C3 University of L'Aquila; Sapienza University Rome; University of Rome Tor
   Vergata
RP Jannini, EA (corresponding author), Univ Roma Tor Vergata, Dept Syst Med, Via Montpellier 1, I-00131 Rome, Italy.
EM eajannini@gmail.com
RI Limoncin, Erika/IQX-0012-2023; Lenzi, Andrea/I-7711-2015
OI CAROSA, Eleonora/0000-0002-6593-6833; Lauro, Davide/0000-0002-8597-4415;
   Lenzi, Andrea/0000-0002-7711-0465; Gravina, Giovanni
   Luca/0000-0002-6797-8324; Jannini, Emmanuele A./0000-0002-5874-039X
FU Italian Ministry of University (MIUR-PRIN Grant); Italian Ministry of
   University (MIUR-FIRB Grant)
FX Authors receive the fund from Italian Ministry of University (MIUR-PRIN
   and FIRB Grants).
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NR 49
TC 23
Z9 24
U1 0
U2 3
PU SPRINGER-VERLAG ITALIA SRL
PI MILAN
PA VIA DECEMBRIO, 28, MILAN, 20137, ITALY
SN 0940-5429
EI 1432-5233
J9 ACTA DIABETOL
JI Acta Diabetol.
PD JUN
PY 2015
VL 52
IS 3
BP 513
EP 521
DI 10.1007/s00592-014-0686-8
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism
GA CJ1HB
UT WOS:000355233500011
PM 25408297
DA 2025-06-11
ER

PT J
AU Mallah, MA
   Soomro, T
   Noreen, S
   Ali, M
   Kafle, A
   Khatoon, N
   Naveed, M
AF Mallah, Manthar Ali
   Soomro, Tahmina
   Noreen, Sobia
   Ali, Mukhtiar
   Kafle, Akriti
   Khatoon, Nafeesa
   Naveed, Muhammad
TI Association of obesity and cardiovascular disease and progress in
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SO INTERNATIONAL JOURNAL OF REHABILITATION RESEARCH
LA English
DT Review
DE BMI; cardiovascular diseases; depression; hypertension; lipids; obesity;
   obesity paradox
ID BODY-MASS INDEX; CORONARY-ARTERY-DISEASE; ALL-CAUSE MORTALITY;
   DENSITY-LIPOPROTEIN CHOLESTEROL; DIETARY ENERGY DENSITY;
   LEFT-VENTRICULAR MASS; C-REACTIVE PROTEIN; ATRIAL-FIBRILLATION;
   ADIPOSE-TISSUE; METABOLIC SYNDROME
AB Obesity has recently emerged as one of the most severe health concerns. Obesity is a key autonomous risk factor for heart failure and contributes to cardiovascular disease (CVD) risk factors such as hypertension, type 2 diabetes, and metabolic abnormalities. Obesity is caused by a metabolic imbalance, which occurs when calories burnt are fewer than the number of calories consumed. There are several pathways accountable for the adverse impacts of obesity on the cardiovascular system. Inflammatory cell infiltration develops in the adipose tissue, the pancreas, and other issues similar to the progression of obesity. Inflammation is triggered by immune cells that invade dysfunctional adipose tissue. The atherosclerotic inflammation phase, related to obesity, induces coronary calcification. Obesity is linked to elevated levels of leptin and high blood pressure. Leptin causes systemic vasoconstriction, sodium retention, and increased blood pressure by influencing the synthesis of nitric oxide and activating the sympathetic nervous system. Obesity is a well-known risk factor for CVD and is one of the leading causes of the greater risk of diseases, including dyslipidemia, hypertension, depression, metabolic syndrome, atrial fibrillation, and heart failure in adults and children. When used with dietary improvements, antiobesity drugs improve the probability of experiencing clinically healthy (5%) weight loss. This review aimed to address the consequences of obesity on cardiac structure and function, risk factors, the impact of the obesity paradox, pharmacological treatment strategies for managing and recommended exercise and diet.
C1 [Mallah, Manthar Ali; Khatoon, Nafeesa] Zhengzhou Univ, Coll Publ Hlth, Zhengzhou, Peoples R China.
   [Soomro, Tahmina] Shah Abdul Latif Univ, Dept Sociol, Khairpur, Pakistan.
   [Noreen, Sobia] Islamia Univ Bahawalpur, Fac Pharm, Dept Pharmaceut, Bahawalpur, Pakistan.
   [Ali, Mukhtiar] Quaid Eawam Univ Engn Sci & Technol, Dept Chem Engn, Nawabshah, Pakistan.
   [Kafle, Akriti] Zhengzhou Univ, Coll Publ Hlth, Nursing Sch, Zhengzhou, Peoples R China.
   [Naveed, Muhammad] Nanjing Med Univ, Sch Pharm, Dept Clin Pharm, Nanjing, Peoples R China.
   [Mallah, Manthar Ali] Zhengzhou Univ, Coll Publ Hlth, Zhengzhou 450001, Peoples R China.
C3 Zhengzhou University; Shah Abdul Latif University; Islamia University of
   Bahawalpur; Zhengzhou University; Nanjing Medical University; Zhengzhou
   University
RP Mallah, MA (corresponding author), Zhengzhou Univ, Coll Publ Hlth, Zhengzhou 450001, Peoples R China.
EM mantharmallah@gmail.com
RI Noreen, Sobia/AAT-8296-2021; Naveed, Muhammad/Y-3856-2018; Mallah,
   Manthar Ali/G-6292-2019
OI Naveed, Muhammad/0000-0002-2193-9266; Noreen, Sobia/0000-0002-4407-6002;
   Mallah, Manthar Ali/0000-0003-1037-9440; Khatoon,
   Nafeesa/0009-0006-1892-4537
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NR 141
TC 5
Z9 5
U1 2
U2 13
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0342-5282
EI 1473-5660
J9 INT J REHABIL RES
JI Int. J. Rehabil. Res.
PD MAR
PY 2023
VL 46
IS 1
BP 14
EP 25
DI 10.1097/MRR.0000000000000565
PG 12
WC Rehabilitation
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Rehabilitation
GA 9J8TR
UT WOS:000940452700002
PM 36727942
DA 2025-06-11
ER

PT J
AU Bialkowska, A
   Górnicka, M
   Zielinska-Pukos, MA
   Hallmann, E
   Hamulka, J
AF Bialkowska, Agnieszka
   Gornicka, Magdalena
   Zielinska-Pukos, Monika A.
   Hallmann, Ewelina
   Hamulka, Jadwiga
TI Plasma Carotenoids and Polyphenols and Their Association with MetS: The
   Need for Nutritional Interventions
SO ANTIOXIDANTS
LA English
DT Article
DE metabolic disorders; MetS severity; carotenoids; polyphenols; lipids
   profile; glucose; inflammation; adults
ID METABOLIC SYNDROME; CARDIOVASCULAR-DISEASE; OXIDATIVE STRESS;
   CHOLESTEROL; CONSUMPTION; FLAVONOIDS; MARKERS; OBESITY; FOODS; JUICE
AB Metabolic syndrome (MetS) is characterized by increased pro-oxidative stress and a chronic inflammation state and their consequent alterations. Several studies have highlighted the protective effect of carotenoids and polyphenols in MetS patients. This study aimed to evaluate the plasma level of selected carotenoids and polyphenols and to determine their relationship with MetS severity, MetS components, and inflammatory markers in Polish adults with metabolic disorders. It was designed as a cross-sectional study. The final study group comprised 275 adults, including 158 women and 117 men. Data were collected on the frequency of consumption of selected food groups. Anthropometric measurements and blood samples were taken to determine the concentration of carotenoids, polyphenols, and indicators (parameters) of metabolic disorders. Plasma concentrations of selected carotenoids and polyphenols were low in adults with MetS. The highest concentrations of carotenoids and polyphenols in the blood were observed for lutein and phenolic acids (including gallic and p-coumaric acids). Nevertheless, a correlation was found between the individual bioactive compounds and MetS components. In terms of the lipid profile, our study showed that the plasma of the selected carotenoids and polyphenols positively correlated with HDL cholesterol (zeaxanthin; total carotenoids), LDL cholesterol (chlorogenic acid), triglycerides (lycopene), and the total cholesterol (kaempferol). We found that the level of CRP as a marker of inflammation negatively correlated with the concentration of zeaxanthin. In our study group, no relationship was found between the dietary antioxidant intensity and the variables studied, which may be attributed to the low frequency of consumption of the sources of bioactive compounds, such as carotenoids and polyphenols, but also to the metabolic disorders. Further research is needed to determine whether these associations are causally related to the metabolic syndrome or are a result of the pathologies of the syndrome or improper diet with a low intake of vegetables and fruit.
C1 [Bialkowska, Agnieszka; Gornicka, Magdalena; Zielinska-Pukos, Monika A.; Hamulka, Jadwiga] Warsaw Univ Life Sci SGGW WULS, Inst Human Nutr Sci, Dept Human Nutr, PL-02787 Warsaw, Poland.
   [Hallmann, Ewelina] Warsaw Univ Life Sci SGGW WULS, Inst Human Nutr Sci, Dept Funct & Organ Food, PL-02787 Warsaw, Poland.
C3 Warsaw University of Life Sciences; Warsaw University of Life Sciences
RP Hamulka, J (corresponding author), Warsaw Univ Life Sci SGGW WULS, Inst Human Nutr Sci, Dept Human Nutr, PL-02787 Warsaw, Poland.
EM agnieszka_bialkowska@sggw.edu.pl; magdalena_gornicka@sggw.edu.pl;
   monika_zielinska_pukos@sggw.edu.pl; ewelina_hallmann@sggw.edu.pl;
   jadwiga_hamulka@sggw.edu.pl
RI Hamulka, Jadwiga/AAC-3436-2021; Górnicka, Magdalena/AAA-6820-2019;
   Hallmann, Ewelina/AAF-7809-2020; Hamulka, Jadwiga/B-1223-2018;
   Zielinska-Pukos, Monika/AAC-7113-2019
OI Magdalena, Gornicka/0000-0002-8805-186X; Hamulka,
   Jadwiga/0000-0003-4933-9016; Zielinska-Pukos,
   Monika/0000-0001-8894-6746; Hallmann, Ewelina/0000-0002-4855-7057
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NR 73
TC 8
Z9 8
U1 2
U2 6
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD JUL
PY 2023
VL 12
IS 7
AR 1336
DI 10.3390/antiox12071336
PG 18
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA N1SO8
UT WOS:001034896300001
PM 37507876
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Singh, VP
   Aggarwal, R
   Singh, S
   Banik, A
   Ahmad, T
   Patnaik, BR
   Nappanveettil, G
   Singh, KP
   Aggarwal, ML
   Ghosh, B
   Agrawal, A
AF Singh, Vijay Pal
   Aggarwal, Rangoli
   Singh, Suchita
   Banik, Arpita
   Ahmad, Tanveer
   Patnaik, Bijay Ranjan
   Nappanveettil, Giridharan
   Singh, Kunal Pratap
   Aggarwal, Madan Lal
   Ghosh, Balaram
   Agrawal, Anurag
TI Metabolic Syndrome Is Associated with Increased Oxo-Nitrative Stress and
   Asthma-Like Changes in Lungs
SO PLOS ONE
LA English
DT Article
ID EXHALED NITRIC-OXIDE; BODY-MASS INDEX; AIRWAY INFLAMMATION;
   INSULIN-RESISTANCE; OBESE SUBJECTS; SYMPTOMS; DEFINITION; PREVALENCE;
   PREDICTOR; IMPACT
AB Epidemiological studies have shown an increased obesity-related risk of asthma. In support, obese mice develop airway hyperresponsiveness (AHR). However, it remains unclear whether the increased risk is a consequence of obesity, adipogenic diet, or the metabolic syndrome (MetS). Altered L-arginine and nitric oxide (NO) metabolism is a common feature between asthma and metabolic syndrome that appears independent of body mass. Increased asthma risk resulting from such metabolic changes would have important consequences in global health. Since high-sugar diets can induce MetS, without necessarily causing obesity, studies of their effect on arginine/NO metabolism and airway function could clarify this aspect. We investigated whether normal-weight mice with MetS, due to high-fructose diet, had dysfunctional arginine/NO metabolism and features of asthma. Mice were fed chow-diet, high-fat-diet, or high-fructose-diet for 18 weeks. Only the high-fat-diet group developed obesity or adiposity. Hyperinsulinemia, hyperglycaemia, and hyperlipidaemia were common to both high-fat-diet and high-fructose-diet groups and the high-fructose-diet group additionally developed hypertension. At 18 weeks, airway hyperresponsiveness (AHR) could be seen in obese high-fat-diet mice as well as non-obese high-fructose-diet mice, when compared to standard chow-diet mice. No inflammatory cell infiltrate or goblet cell metaplasia was seen in either high-fat-diet or high-fructose-diet mice. Exhaled NO was reduced in both these groups. This reduction in exhaled NO correlated with reduced arginine bioavailability in lungs. In summary, mice with normal weight but metabolic obesity show reduced arginine bioavailability, reduced NO production, and asthma-like features. Reduced NO related bronchodilation and increased oxo-nitrosative stress may contribute to the pathogenesis.
C1 [Singh, Vijay Pal; Aggarwal, Rangoli; Singh, Suchita; Banik, Arpita; Ahmad, Tanveer; Patnaik, Bijay Ranjan; Singh, Kunal Pratap; Ghosh, Balaram; Agrawal, Anurag] CSIR Inst Genom & Integrat Biol, Ctr Excellence Translat Res Asthma & Lung Dis, Delhi, India.
   [Nappanveettil, Giridharan] Natl Inst Nutr, Natl Ctr Lab Anim Sci, Hyderabad 500007, Andhra Pradesh, India.
   [Aggarwal, Madan Lal] Shriram Inst Ind Res, Delhi, India.
C3 Council of Scientific & Industrial Research (CSIR) - India; CSIR -
   Institute of Genomics & Integrative Biology (IGIB); Indian Council of
   Medical Research (ICMR); ICMR - National Institute of Nutrition (NIN);
   ICMR - National Animal Resource Facility for Biomedical Research
   (NARFBR)
RP Singh, VP (corresponding author), CSIR Inst Genom & Integrat Biol, Ctr Excellence Translat Res Asthma & Lung Dis, Delhi, India.
EM vp.singh@igib.res.in
RI Singh, Prahat/HZH-4129-2023; Agrawal, Anurag/GZL-5821-2022; Pratap,
   Kunal/E-9042-2017
OI Ahmad, Tanveer/0000-0002-8384-5273; Singh, Vijay
   Pal/0000-0003-0547-3336; Pratap, Kunal/0000-0002-3888-2577; Agrawal,
   Anurag/0000-0002-0340-5252
FU Lady Tata Memorial Trust; CSIR (Council of Scientific and Industrial
   Research) MLP (Mega Laboratory Project) [5502]; CSIR (Council of
   Scientific and Industrial Research) BSC (Biological Science Cluster)
   project [0403]; DST (Department of Science and Technology); ICMR (Indian
   Council of Medical Research)
FX Funding was provided by the Lady Tata Memorial Trust, CSIR (Council of
   Scientific and Industrial Research) MLP (Mega Laboratory Project) 5502 &
   BSC (Biological Science Cluster) 0403 projects, the DST (Department of
   Science and Technology) Swarnjayanti awards for the financial support
   and ICMR (Indian Council of Medical Research) for scholarship of Suchita
   Singh. The funders had no role in study design, data collection and
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NR 46
TC 56
Z9 60
U1 2
U2 8
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JUN 22
PY 2015
VL 10
IS 6
AR e0129850
DI 10.1371/journal.pone.0129850
PG 15
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA CL3FM
UT WOS:000356835800043
PM 26098111
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Boulos, M
   Mousa, RS
   Jeries, N
   Simaan, E
   Alam, K
   Bulus, B
   Assy, N
AF Boulos, Mariana
   Mousa, Rabia S.
   Jeries, Nizar
   Simaan, Elias
   Alam, Klode
   Bulus, Bulus
   Assy, Nimer
TI Hidden in the Fat: Unpacking the Metabolic Tango Between Metabolic
   Dysfunction-Associated Steatotic Liver Disease and Metabolic Syndrome
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE metabolic syndrome; MASLD mechanisms; future directions
ID COA CARBOXYLASE INHIBITION; FECAL MICROBIOTA TRANSPLANTATION; GAMMA
   AGONIST PIOGLITAZONE; ACTIVATED-RECEPTOR-GAMMA; PLACEBO-CONTROLLED
   TRIAL; IRRITABLE-BOWEL-SYNDROME; LIFE-STYLE MODIFICATION; NONALCOHOLIC
   STEATOHEPATITIS; INSULIN-RESISTANCE; OBETICHOLIC ACID
AB Metabolic syndrome (MetS) and metabolic dysfunction-associated steatotic liver disease (MASLD) are closely related, with rapidly increasing prevalence globally, driving significant public health concerns. Both conditions share common pathophysiological mechanisms such as insulin resistance (IR), adipose tissue dysfunction, oxidative stress, and gut microbiota dysbiosis, which contribute to their co-occurrence and progression. While the clinical implications of this overlap, including increased cardiovascular, renal, and hepatic risk, are well recognized, current diagnostic and therapeutic approaches remain insufficient due to the clinical and individuals' heterogeneity and complexity of these diseases. This review aims to provide an in-depth exploration of the molecular mechanisms linking MetS and MASLD, identify critical gaps in our understanding, and highlight existing challenges in early detection and treatment. Despite advancements in biomarkers and therapeutic interventions, the need for a comprehensive, integrated approach remains. The review also discusses emerging therapies targeting specific pathways, the potential of precision medicine, and the growing role of artificial intelligence in enhancing research and clinical management. Future research is urgently needed to combine multi-omics data, precision medicine, and novel biomarkers to better understand the complex interactions between MetS and MASLD. Collaborative, multidisciplinary efforts are essential to develop more effective diagnostic tools and therapies to address these diseases on a global scale.
C1 [Boulos, Mariana; Mousa, Rabia S.; Jeries, Nizar; Simaan, Elias; Alam, Klode; Bulus, Bulus; Assy, Nimer] Galilee Med Ctr, Internal Med Dept, IL-221001 Nahariyya, Israel.
   [Boulos, Mariana; Assy, Nimer] Bar Ilan Univ, Azrieli Fac Med, IL-1311502 Safed, Israel.
C3 Western Galilee Hospital; Bar Ilan University
RP Boulos, M (corresponding author), Galilee Med Ctr, Internal Med Dept, IL-221001 Nahariyya, Israel.; Boulos, M (corresponding author), Bar Ilan Univ, Azrieli Fac Med, IL-1311502 Safed, Israel.
EM marianab@gmc.gov.il; rabia.mousa@gmail.com; nizar_j_93@hotmail.com;
   eliasol937@gmail.com; klod_alam@hotmail.com; bulus.91@gmail.com;
   nimera@gmc.gov.il
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NR 329
TC 1
Z9 1
U1 1
U2 1
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD APR 7
PY 2025
VL 26
IS 7
AR 3448
DI 10.3390/ijms26073448
PG 44
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 1FR1Q
UT WOS:001463911000001
PM 40244398
DA 2025-06-11
ER

PT J
AU Reddy, P
   Lent-Schochet, D
   Ramakrishnan, N
   McLaughlin, M
   Jialal, I
AF Reddy, Priya
   Lent-Schochet, Daniella
   Ramakrishnan, Neeraj
   McLaughlin, Matthew
   Jialal, Ishwarlal
TI Metabolic syndrome is an inflammatory disorder: A conspiracy between
   adipose tissue and phagocytes
SO CLINICA CHIMICA ACTA
LA English
DT Review
DE Inflammation; Adipokines; Metabolic syndrome; C-reactive protein;
   Fibrinogen; Macrophages; Chemokines; Metabolomics
ID C-REACTIVE PROTEIN; NEUTROPHIL-LYMPHOCYTE RATIO;
   LIPOPOLYSACCHARIDE-BINDING PROTEIN; TUMOR-NECROSIS-FACTOR;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; ENDOTHELIAL-CELLS;
   PLASMA-FIBRINOGEN; OBESITY; RISK
AB Metabolic syndrome (MetS) describes a cluster of cardio-metabolic factors that predispose to type 2 diabetes mellitus (T2DM) and atherosclerotic cardiovascular disease (ASCVD). While 35% of Americans suffer from this disorder, the specific pathways related to this disease are largely underexplored. The prevailing consensus is that inflammatory pathways contribute to the pathogenesis of this disease, and therefore new research has uncovered how inflammation plays a critical role in the development and progression of MetS. The purpose of this review is to understand the role of major inflammatory mechanisms and their role in MetS. Our review identifies that adipose tissue (AT) contributes to the inflammatory pathways through the release of pro-inflammatory adipokines such as leptin and chemerin and dysregulation of anti-inflammatory adiponectin. Chemokines and cytokines deriving from monocytes are also altered and promote inflammation and insulin resistance. Circulating inflammatory biomarkers including C-reactive protein (CRP), fibrinogen, Serum amyloid A (SAA), cytokines, and chemokines have also been linked to the pathogenesis of MetS. Researchers have identified the significance of CRP levels in predicting future sequelae of MetS such as ASCVD. Mast cells in subcutaneous adipose tissue (SAT) promote both inflammation and fibrosis. Thus, both AT and phagocyte activity define MetS as an inflammatory disorder.
C1 [Reddy, Priya; Lent-Schochet, Daniella; Ramakrishnan, Neeraj; McLaughlin, Matthew; Jialal, Ishwarlal] Calif Northstate Univ, Coll Med, Elk Grove, CA 95757 USA.
   [Jialal, Ishwarlal] VA Med Ctr, Mather, CA 95757 USA.
RP Jialal, I (corresponding author), VA Med Ctr, Sect Clin Chem, 9700 West Taron Dr, Elk Grove, CA 95757 USA.; Jialal, I (corresponding author), Calif North State Univ, Coll Med, Res, 9700 West Taron Dr, Elk Grove, CA 95757 USA.
EM ishwarlal.jialal@cnsu.edu
RI Jialal, Ishwarlal/AAG-6218-2019
FU California Northstate University minigrant
FX California Northstate University minigrant.
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NR 88
TC 199
Z9 214
U1 3
U2 55
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0009-8981
EI 1873-3492
J9 CLIN CHIM ACTA
JI Clin. Chim. Acta
PD SEP
PY 2019
VL 496
BP 35
EP 44
DI 10.1016/j.cca.2019.06.019
PG 10
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA IQ3RX
UT WOS:000480669900006
PM 31229566
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Kasbi-Chadli, F
   Coué, M
   Aguesse, A
   Grit, I
   Souque, T
   Ferchaud-Roucher, V
   Ouguerram, K
AF Kasbi-Chadli, Fatima
   Coue, Marine
   Aguesse, Audrey
   Grit, Isabelle
   Souque, Thomas
   Ferchaud-Roucher, Veronique
   Ouguerram, Khadija
TI Spirulina liquid extract prevents metabolic disturbances and improves
   liver sphingolipids profile in hamster fed a high-fat diet
SO EUROPEAN JOURNAL OF NUTRITION
LA English
DT Article
DE Spirulina liquid extract; Glycemia; Dyslipidemia; Oxidative stress;
   Hamster
ID INDUCED INSULIN-RESISTANCE; SKELETAL-MUSCLE; C-PHYCOCYANIN; PLATENSIS
   SUPPLEMENTATION; APOLIPOPROTEIN-B; CERAMIDE; ANTIOXIDANT; OBESITY; ACID;
   DEFICIENCY
AB Purpose Metabolic syndrome is characterized by hyperglycemia, hyperlipemia and exacerbated oxidative stress. The aim of the study was to determine whether Spirulysat(R), a Spirulina liquid extract (SLE) enriched in phycocyanin, would prevent metabolic abnormalities induced by high-fat diet. Methods The effect of acute SLE supplementation on postprandial lipemia and on triton-induced hyperlipidemia was studied in hamster fed control diet (C). The effect of chronic SLE supplementation on lipid content in plasma, liver and aorta, and on glycemia and oxidative stress was studied in hamster fed control (C) or high-fat diet (HF) for two weeks and then treated with SLE for two weeks (CSp and HFSp) or not (C and HF). Results The acute SLE supplementation lowered plasma cholesterol and non-esterified fatty acid concentrations after olive oil gavage (P < 0.05) in CSp, while no effect was observed on triglyceridemia. HFD increased plasma MDA, basal glycemia, triglyceridemia, total plasma cholesterol, VLDL, LDL and HDL cholesterol, ceramide, sphingomyelin and glucosylceramide content in liver in HF compared to C (P < 0.05). SLE did not affect SOD and GPx activities nor total antioxidant status in HFSp group but lowered glycemia, glucoceramide and cholesterol in liver and cholesterol in aorta compared to HF (P < 0.05). SLE also decreased HMGCoA and TGF-beta 1 gene expression in liver (P < 0.05) and tended to lower G6Pase (P = 0.068) gene expression in HFSp compared to HF. Conclusion Although 2-week SLE supplementation did not affect oxidative stress, it protected from hyperglycemia and lipid accumulation in liver and aorta suggesting a protective effect against metabolic syndrome.
C1 [Kasbi-Chadli, Fatima; Coue, Marine; Aguesse, Audrey; Grit, Isabelle; Souque, Thomas; Ferchaud-Roucher, Veronique; Ouguerram, Khadija] Univ Nantes, INRAe UMR1280 PhAN, Physiopathol Nutr Adaptat, CHU Hotel Dieu,IMAD,CRNH Ouest, 1 Pl Alexis Ricordeau, F-44093 Nantes 01, France.
C3 Nantes Universite; CHU de Nantes; INRAE
RP Kasbi-Chadli, F (corresponding author), Univ Nantes, INRAe UMR1280 PhAN, Physiopathol Nutr Adaptat, CHU Hotel Dieu,IMAD,CRNH Ouest, 1 Pl Alexis Ricordeau, F-44093 Nantes 01, France.
EM fatima.chadli-kasbi@univ-nantes.fr; marine.coue@univ-nantes.fr;
   audrey.aguesse@univ-nantes.fr; isabelle.grit@univ-nantes.fr;
   thomas.souquet@etu.univ-nantes.fr;
   veronique.ferchaud-roucher@univ-nantes.fr;
   khadija.ouguerram@univ-nantes.fr
RI Coué, Marine/AAL-3942-2021
OI FERCHAUD-ROUCHER, Veronique/0000-0001-6809-1488; Coue,
   Marine/0000-0001-8435-7143
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NR 51
TC 6
Z9 6
U1 1
U2 12
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1436-6207
EI 1436-6215
J9 EUR J NUTR
JI Eur. J. Nutr.
PD DEC
PY 2021
VL 60
IS 8
BP 4483
EP 4494
DI 10.1007/s00394-021-02589-x
EA JUN 2021
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA WS2TS
UT WOS:000659819600001
PM 34110469
DA 2025-06-11
ER

PT J
AU Martínez-Hernández, A
   Córdova, EJ
   Rosillo-Salazar, O
   García-Ortíz, H
   Contreras-Cubas, C
   Islas-Andrade, S
   Revilla-Monsalve, C
   Salas-Labadía, C
   Orozco, L
AF Martinez-Hernandez, Angelica
   Cordova, Emilio J.
   Rosillo-Salazar, Oscar
   Garcia-Ortiz, Humberto
   Contreras-Cubas, Cecilia
   Islas-Andrade, Sergio
   Revilla-Monsalve, Cristina
   Salas-Labadia, Consuelo
   Orozco, Lorena
TI Association of HMOX1 and NQO1 Polymorphisms with Metabolic
   Syndrome Components
SO PLOS ONE
LA English
DT Article
ID HEME OXYGENASE-1 GENE; OXIDATIVE STRESS; CARBON-MONOXIDE;
   NAD(P)H-QUINONE OXIDOREDUCTASE-1; ENDOTHELIAL DYSFUNCTION;
   MICROSATELLITE REPEATS; C609T POLYMORPHISM; NATIONAL-HEALTH; IRON
   STATUS; PROMOTER
AB Metabolic syndrome (MetS) is among the most important public health problems worldwide, and is recognized as a major risk factor for various illnesses, including type 2 diabetes mellitus, obesity, and cardiovascular diseases. Recently, oxidative stress has been suggested as part of MetS aetiology. The heme oxygenase 1 (HMOX1) and NADH: quinone oxidoreductase 1 (NQO1) genes are crucial mediators of cellular defence against oxidative stress. In the present study, we analysed the associations of HMOX1 (GT)n and NQO1 C609T polymorphisms with MetS and its components. Our study population comprised 735 Mexican Mestizos unrelated volunteers recruited from different tertiary health institutions from Mexico City. In order to know the HMOX1 (GT) n and NQO1 C609T allele frequencies in Amerindians, we included a population of 241 Amerindian native speakers. Their clinical and demographic data were recorded. The HMOX1 (GT) n polymorphism was genotyped using PCR and fluorescence technology. NQO1 C609T polymorphism genotyping was performed using TaqMan probes. Short allele (<25 GT repeats) of the HMOX1 polymorphism was associated with high systolic and diastolic blood pressure, and the T allele of the NQO1 C609T polymorphism was associated with increased triglyceride levels and decreased HDL-c levels, but only in individuals with MetS. This is the first study to analyse the association between MetS and genes involved in oxidative stress among Mexican Mestizos. Our data suggest that polymorphisms of HMOX1 and NQO1 genes are associated with a high risk of metabolic disorders, including high systolic and diastolic blood pressure, hypertriglyceridemia, and low HDL-c levels in Mexican Mestizo individuals.
C1 [Martinez-Hernandez, Angelica; Cordova, Emilio J.; Rosillo-Salazar, Oscar; Garcia-Ortiz, Humberto; Contreras-Cubas, Cecilia; Orozco, Lorena] Inst Nacl Med Genom, SS, Immunogen & Metab Dis Lab, Mexico City, DF, Mexico.
   [Islas-Andrade, Sergio; Revilla-Monsalve, Cristina] IMSS, Ctr Med Nacl Siglo 21, Med Res Unit Metab Dis, Mexico City, DF, Mexico.
   [Salas-Labadia, Consuelo] Inst Nacl Pediat, SS, Dept Human Genet, Tissue Culture Lab, Mexico City, DF, Mexico.
C3 Instituto Nacional de Medicina Genomica; Instituto Mexicano del Seguro
   Social
RP Orozco, L (corresponding author), Inst Nacl Med Genom, SS, Immunogen & Metab Dis Lab, Mexico City, DF, Mexico.
EM lorozco@inmegen.gob.mx
RI Revilla-Monsalve, Cristina/ABG-6663-2021
OI Rosillo Salazar, Oscar Daniel/0000-0002-6393-2409; Orozco,
   Lorena/0000-0002-5801-9180; Revilla Monsalve, Maria
   Cristina/0000-0002-6202-1160; Garcia-Ortiz,
   Humberto/0000-0002-0453-980X; Martinez-H, Angelica/0000-0001-9883-2988;
   salas, consuelo/0000-0002-3301-7357
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NR 44
TC 23
Z9 26
U1 0
U2 1
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAY 1
PY 2015
VL 10
IS 5
AR e0123313
DI 10.1371/journal.pone.0123313
PG 12
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA CH2XA
UT WOS:000353887100019
PM 25933176
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Hackett, G
   Cole, N
   Bhartia, M
   Kennedy, D
   Raju, J
   Wilkinson, P
AF Hackett, Geoffrey
   Cole, Nigel
   Bhartia, Mithun
   Kennedy, David
   Raju, Jessie
   Wilkinson, Peter
TI Testosterone Replacement Therapy with Long-Acting Testosterone
   Undecanoate Improves Sexual Function and Quality-of-Life Parameters vs.
   Placebo in a Population of Men with Type 2 Diabetes
SO JOURNAL OF SEXUAL MEDICINE
LA English
DT Article
DE AMSAgeing Male Symptom Score; IIEFInternational Index of Erectile
   Function; HADSHospital Anxiety and Depression Scale; TDStestosterone
   deficiency syndrome; TRTtestosterone replacement therapy; LOHlate-onset
   hypogonadism; T2Dtype 2 diabetes; TUTestosterone Undecanoate;
   NICENational Institute for Health and Clinical Excellence; QoFquality
   outcome framework
ID RANDOMIZED CONTROLLED-TRIAL; LATE-ONSET HYPOGONADISM; LOW SERUM
   TESTOSTERONE; ERECTILE DYSFUNCTION; AGING MEN; OLDER MEN; METABOLIC
   SYNDROME; DEPRESSION; METAANALYSIS; SUPPLEMENTATION
AB Introduction Sexual dysfunction, particularly erectile dysfunction (ED), is common in men with type 2 diabetes, occurring in up to 75% of cases. The prevalence of hypogonadism is also high in men with diabetes and low testosterone is associated with both sexual dysfunction and a reduced response to oral therapy for ED. Aim This study aimed to determine the effect of testosterone replacement with long-acting Testosterone Undecanoate (TU) on sexual function, mood and quality of life vs. placebo over a treatment period of 30 weeks followed by 52 weeks of open-label medication. The study was conducted in a primary care population of men with type 2 diabetes attending their primary care physician for routine visits. Methods The male diabetic populations of seven general practices were screened at routine diabetes visits to detect symptomatic men with total testosterone levels of 12nmol/L or less or with free testosterones of 250pmol/L or less. Two hundred eleven men were screened. A double-blind placebo-controlled study was conducted in 199 men with type 2 diabetes and hypogonadism treated for 30 weeks with either 1,000mg of TU or matching placebo followed by 52-week open-label follow on. Main Outcome Measures The primary outcome measure, International Index of Erectile Function (IIEF), was used to evaluate sexual dysfunction, and the Ageing Male Symptom (AMS), Hospital Anxiety and Depression Scale, and Global Efficacy Question were used as secondary outcome measures to assess mood and self-reported quality of life. Results Testosterone replacement therapy with long-acting TU improved all domains of sexual function at 30 weeks (erectile function [EF], P=0.005; intercourse satisfaction, P=0.015; sexual desire, P=0.001; overall satisfaction, P=0.05; and orgasm, P=0.04), with benefit as early as 6 weeks. Improvements in AMS score were significant in men without depression (P=0.02) and the presence of depression at baseline was associated with marked reduction in response to both sexual function and psychological scores. All responses in sexual function continued to improve significantly up to 18 months with an improvement in EF score of 4.31 from baseline. In a small cohort of 35 men taking phosphodiesterase type 5 inhibitors, there was no change during the double-blind phase but a nine-point improvement in EF domain during 52-week open-label treatment. After 30 weeks, 46% vs. 17% of patients on active therapy vs. placebo felt that the treatment had improved their health, reaching 70% after open-label therapy. Less obese and older patients responded better to testosterone therapy. There were no significant adverse events. Conclusion TU significantly improved all domains of the IIEF and patient reported quality of life at 30 weeks and more significantly after 52-week open-label extension. Improvement was most marked in less obese patient and those without coexisting depression. In men with type 2 diabetes, trials of therapy may need to be given for much longer than 3-6 months suggested in current guidelines.
C1 [Hackett, Geoffrey; Bhartia, Mithun; Kennedy, David; Raju, Jessie] Good Hope Hosp, Sutton Coldfield B75 7RR, England.
   [Cole, Nigel] Cloisters Practice, Lichfield, England.
   [Wilkinson, Peter] Wilkinson Associates, Radnor, Herts, England.
C3 Heart of England NHS Foundation Trust; Good Hope Hospital
RP Hackett, G (corresponding author), Good Hope Hosp, Sutton Coldfield B75 7RR, England.
EM Geoff.hackett@virgin.net
FU Bayer
FX This was an investigator-initiated and sponsored study with no influence
   on the intellectual content. Bayer supplied medication and financial
   support for investigator costs.
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NR 52
TC 131
Z9 140
U1 0
U2 18
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1743-6095
EI 1743-6109
J9 J SEX MED
JI J. Sex. Med.
PD JUN
PY 2013
VL 10
IS 6
BP 1612
EP 1627
DI 10.1111/jsm.12146
PG 16
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 157DZ
UT WOS:000319877400019
PM 23551886
DA 2025-06-11
ER

PT J
AU Aisya, RW
   Nugroho, HSKH
   Widyastiti, NS
   Tjahjono, K
   Afifah, DN
AF Aisya, Rizki Widyan
   Nugroho, H. S. K. Heri
   Widyastiti, Nyoman Suci
   Tjahjono, Kusmiyati
   Afifah, Diana Nur
TI The Effectiveness of Aloe-based Drink in Reducing Glycated Albumin and
   Insulin Resistance of Metabolic Syndrome: A Randomized Clinical Trial
SO CURRENT RESEARCH IN NUTRITION AND FOOD SCIENCE
LA English
DT Article
DE Aloe-Based Drink; Glycated Albumin; Insulin Resistance; Metabolic
   Syndrome
ID OXIDATIVE STRESS; ANTIOXIDANT; DISEASE
AB Insulin resistance (IR) has an important role in the pathology that forms the metabolic syndrome (MetS). Glycated Albumin (GA) has a role as an index of glycemic control associated with MetS. Aloe vera (Aloe barbadensis Miller) is a plant that has anti-diabetic and anti-hypercholesterolemic function. This study aims to investigate the effect of Aloe-based drink on GA and IR in MetS. This study was a true experimental using pre-post randomized control group design. Thirty-eight MetS subjects were divided into two groups: treatment group (n=19) which was provided by 165 g/d of Aloe-based drink for 4 weeks; and the control group (n=19). Both groups were given education regarding of management of MetS. GA was measured by using an ELISA method and IR calculated by HOMA-IR of both groups and statistically analyzed at baseline and the end of treatment. The data were analyzed using paired t-test and independent t-test. At the end of the study, the treatment group showed reduction of GA and HOMA-IR statistically significant (GA=-4.32.35%;p<0.001; HOMA-IR=-1.6 1.87; p=0.001). Compared to control group, the change of GA and HOMA-IR in intervention group were also significantly different (p<0.001; p<0.001). Aloe-based drink was proven to reduce GA and IR in the MetS.
C1 [Aisya, Rizki Widyan; Afifah, Diana Nur] Diponegoro Univ, Dept Nutr Sci, Fac Med, Semarang, Indonesia.
   [Nugroho, H. S. K. Heri] Diponegoro Univ, Dept Internal Med, Fac Med, Semarang, Indonesia.
   [Widyastiti, Nyoman Suci] Diponegoro Univ, Dept Clin Pathol, Fac Med, Semarang, Indonesia.
   [Tjahjono, Kusmiyati] Diponegoro Univ, Dept Biochem, Fac Med, Semarang, Indonesia.
C3 Diponegoro University; Diponegoro University; Diponegoro University;
   Diponegoro University
RP Afifah, DN (corresponding author), Diponegoro Univ, Dept Nutr Sci, Fac Med, Semarang, Indonesia.
EM d.nurafifah.dna@fk.undip.ac.id
RI Afifah, Diana Nur/AAK-7171-2020; Widyastiti, Nyoman Suci/GQO-8245-2022
OI Nugroho, Heri/0000-0001-7875-6973
CR Aydin S, 2014, NUTRITION, V30, P1, DOI 10.1016/j.nut.2013.05.013
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NR 27
TC 1
Z9 1
U1 0
U2 1
PU ENVIRO RESEARCH PUBLISHERS
PI BHOPAL
PA 14 GREEN HOUSE, PRINCE COLONY, SHAHJAHANABAD, BHOPAL, MADHYA PRADESH 462
   001, INDIA
SN 2347-467X
EI 2322-0007
J9 CURR RES NUTR FOOD S
JI Curr. Res. Nutr. Food Sci.
PD AUG
PY 2022
VL 10
IS 2
BP 566
EP 574
DI 10.12944/CRNFSJ.10.2.13
PG 9
WC Food Science & Technology
WE Emerging Sources Citation Index (ESCI)
SC Food Science & Technology
GA 6G0SA
UT WOS:000884469700011
OA gold
DA 2025-06-11
ER

PT J
AU Archontogeorgis, K
   Voulgaris, A
   Papanas, N
   Nena, E
   Xanthoudaki, M
   Pataka, A
   Schiza, SE
   Rizzo, M
   Froudarakis, ME
   Steiropoulos, P
AF Archontogeorgis, Kostas
   Voulgaris, Athanasios
   Papanas, Nikolaos
   Nena, Evangelia
   Xanthoudaki, Maria
   Pataka, Athanasia
   Schiza, Sophia E.
   Rizzo, Manfredi
   Froudarakis, Marios E.
   Steiropoulos, Paschalis
TI Metabolic Syndrome in Patients with Coexistent Obstructive Sleep Apnea
   Syndrome and Chronic Obstructive Pulmonary Disease (Overlap Syndrome)
SO METABOLIC SYNDROME AND RELATED DISORDERS
LA English
DT Article
DE chronic obstructive pulmonary disease; metabolic syndrome; obstructive
   sleep apnea syndrome; overlap syndrome; obesity
ID OXIDATIVE STRESS; COMORBIDITIES; ASSOCIATION; COPD; CONSEQUENCES;
   PREVALENCE; PREDICTORS; COMPONENTS; OBESITY; LUNG
AB Background: Evidence suggests that metabolic syndrome (MetS) is highly prevalent in patients with obstructive sleep apnea syndrome (OSAS) and chronic obstructive pulmonary disease (COPD). However, data on the prevalence of MetS in patients having both OSAS and COPD, or overlap syndrome (OS), are scarce. The aim of this study was to evaluate the prevalence and identify predictors of MetS in patients with OS.
   Methods: MetS was evaluated in consecutive patients who were diagnosed with OS by polysomnography and pulmonary function testing.
   Results: A total of 163 subjects (138 males and 25 females) were included. MetS was present in 38% of OS patients. Patients were divided into group A (OS without MetS group: 101 patients) and group B (OS with MetS group: 62 patients). Groups were similar in terms of pulmonary function and sleep parameters. In group B, abdominal obesity was the most prevalent component of MetS (100%), followed by hypertension (82.3%), hypertriglyceridemia (72.6%), and hyperglycemia (51.6%). Age (P = 0.009) and body mass index (P = 0.029) were independent predictors of MetS in patients with OS.
   Conclusions: An increased prevalence of MetS was observed in a group of patients with OS. Early identification and treatment of MetS may play a significant role in prevention of complications related to OS.
C1 [Archontogeorgis, Kostas; Voulgaris, Athanasios; Steiropoulos, Paschalis] Democritus Univ Thrace, MSc Program Sleep Med, Med Sch, Alexandroupolis, Greece.
   [Voulgaris, Athanasios; Xanthoudaki, Maria; Froudarakis, Marios E.; Steiropoulos, Paschalis] Democritus Univ Thrace, Dept Pneumonol, Med Sch, Alexandroupolis 68100, Greece.
   [Papanas, Nikolaos] Democritus Univ Thrace, Dept Internal Med 2, Med Sch, Alexandroupolis, Greece.
   [Nena, Evangelia] Democritus Univ Thrace, Lab Hyg & Environm Protect, Med Sch, Alexandroupolis, Greece.
   [Pataka, Athanasia] Aristotle Univ Thessaloniki, G Papanikolaou Gen Hosp, Resp Failure Unit, Thessaloniki, Greece.
   [Schiza, Sophia E.] Univ Crete, Med Sch, Dept Resp Med, Sleep Disorders Unit, Iraklion, Greece.
   [Rizzo, Manfredi] Univ Palermo, Biomed Dept Internal Med & Med Specialties, Sch Med, Palermo, Italy.
   [Rizzo, Manfredi] Univ South Carolina, Div Endocrinol Diabet & Metab, Sch Med Columbia, Columbia, SC 29208 USA.
C3 Democritus University of Thrace; Democritus University of Thrace;
   Democritus University of Thrace; Democritus University of Thrace;
   Aristotle University of Thessaloniki; George Papanikolaou General
   Hospital of Thessaloniki; University of Crete; University of Palermo;
   University of South Carolina System; University of South Carolina
   Columbia
RP Voulgaris, A (corresponding author), Democritus Univ Thrace, Dept Pneumonol, Med Sch, Alexandroupolis 68100, Greece.
EM thanasisvoul@hotmail.com
RI RIZZO, MANFREDI/GZL-0551-2022; Voulgaris, Athanasios/IUM-9495-2023;
   Nena, Evangelia/AAD-9385-2019; Steiropoulos, Paschalis/AAH-6905-2021
OI Nena, Evangelia/0000-0003-0381-4715
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NR 40
TC 7
Z9 7
U1 0
U2 4
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-4196
EI 1557-8518
J9 METAB SYNDR RELAT D
JI Metab. Syndr. Relat. Disord.
PD AUG 1
PY 2020
VL 18
IS 6
BP 296
EP 301
DI 10.1089/met.2019.0126
EA MAY 2020
PG 6
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA MR7KE
UT WOS:000533203300001
PM 32379990
DA 2025-06-11
ER

PT J
AU Matsumori, R
   Miyazaki, T
   Shimada, K
   Kume, A
   Kitamura, Y
   Oshida, K
   Yanagisawa, N
   Kiyanagi, T
   Hiki, M
   Fukao, K
   Hirose, K
   Ohsaka, H
   Mokuno, H
   Daida, H
AF Matsumori, Rie
   Miyazaki, Tetsuro
   Shimada, Kazunori
   Kume, Atsumi
   Kitamura, Yohei
   Oshida, Kyoichi
   Yanagisawa, Naotake
   Kiyanagi, Takashi
   Hiki, Makoto
   Fukao, Kosuke
   Hirose, Kuniaki
   Ohsaka, Hiromichi
   Mokuno, Hiroshi
   Daida, Hiroyuki
TI High levels of very long-chain saturated fatty acid in erythrocytes
   correlates with atherogenic lipoprotein profiles in subjects with
   metabolic syndrome
SO DIABETES RESEARCH AND CLINICAL PRACTICE
LA English
DT Article
DE Atherogenic lipoproteins; Inflammation; Metabolic syndrome; Peroxisomal
   dysfunction; Saturated very long-chain fatty acid
ID RED-BLOOD-CELLS; OXIDATIVE STRESS; CHOLESTEROL; SERUM; LDL; MORTALITY;
   CYTOKINES; MEMBRANES; PLASMA; RISK
AB Aim: Very long chain saturated fatty acid (VLCFA) levels in erythrocytes are associated with metabolic syndrome (MS). However, the relationship between levels of the VLCFA ligonoceric acid (C24:0) in erythrocytes and the atherogenic lipoprotein profiles and inflammatory state in MS remain unclear.
   Methods: Based on the International Diabetes Federation (IDF) definition of MS, 195 apparently healthy males were assigned to either an MS group (n = 38) or a non-MS group (n = 157). Fatty acid composition of erythrocytes was determined by gas liquid chromatography.
   Results: Erythrocytes from the MS group had a significantly higher level of C24: 0 than cells from the non-MS group (4.06 +/- 0.48% versus 3.88 +/- 0.34%; p = 0.03). C24: 0 levels were significantly correlated with several components of MS. The C24: 0 levels showed a significant negative correlation with LDL and HDL particle size. Multivariate linear regression analysis showed that C24: 0 levels were independently correlated with LDL particle size after adjusting for age and each MS criterion. C24: 0 levels were also positively correlated with log-transformed high-sensitivity CRP levels (p = 0.04).
   Conclusion: C24: 0 levels in erythrocytes are associated with specific atherogenic lipoprotein profiles and inflammation status in subjects with MS. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
C1 [Matsumori, Rie; Miyazaki, Tetsuro; Shimada, Kazunori; Kume, Atsumi; Kiyanagi, Takashi; Hiki, Makoto; Fukao, Kosuke; Hirose, Kuniaki; Ohsaka, Hiromichi; Mokuno, Hiroshi; Daida, Hiroyuki] Juntendo Univ, Dept Cardiovasc Med, Sch Med, Tokyo 1138421, Japan.
   [Kitamura, Yohei; Yanagisawa, Naotake] Morinaga Milk Ind Co Ltd, Nutr Res Dept, Nutr Sci Inst, Zama, Kanagawa, Japan.
   [Oshida, Kyoichi] Kemin Japan KK, Tokyo, Japan.
C3 Juntendo University; Morinaga Milk Industry Company, Ltd
RP Miyazaki, T (corresponding author), Juntendo Univ, Dept Cardiovasc Med, Sch Med, 2-1-1 Hongo Bunkyo Ku, Tokyo 1138421, Japan.
EM tetsuro@juntendo.ac.jp
RI ohsaka, hiromichi/AAQ-4712-2020
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NR 35
TC 25
Z9 25
U1 3
U2 20
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0168-8227
EI 1872-8227
J9 DIABETES RES CLIN PR
JI Diabetes Res. Clin. Pract.
PD JAN
PY 2013
VL 99
IS 1
BP 12
EP 18
DI 10.1016/j.diabres.2012.10.025
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 055DS
UT WOS:000312396000008
PM 23146370
DA 2025-06-11
ER

PT J
AU Cha, JC
   Ivanov, V
   Roomi, MW
   Kalinovsky, T
   Niedzwiecki, A
   Rath, M
AF Cha, J. C.
   Ivanov, V.
   Roomi, M. W.
   Kalinovsky, T.
   Niedzwiecki, A.
   Rath, M.
TI Nutritional improvement of metabolic syndrome parameters in immature
   fructose-fed wild-type mice
SO MOLECULAR MEDICINE REPORTS
LA English
DT Article
DE diabetes nutrient mix; metformin; C57/BL6 J wild-type mice; fructose
   diet; metabolic syndrome parameters; fructosamine; lipid profile;
   systolic blood pressure
ID DIABETES-MELLITUS; INSULIN SENSITIVITY; OXIDATIVE STRESS; RATS; ACID;
   GLYCATION; COLLAGEN; GLUCOSE; DIET; MECHANISM
AB The incidence of type 2 diabetes mellitus is on the increase worldwide, with both environmental and genetic factors implicated in its development. Diabetes is often preceded by metabolic syndrome (MS) and may develop in normal adults ingesting a high fructose diet. The effect of high fructose intake on the development of MS in children and adolescents is less clear. Our objective was to study the effects of a nutrient mixture and metformin (MET), a widely used oral diabetic medication, in modulating the physiological and biochemical parameters of a high fructose diet in immature mice. C57BL/6J wild-type mice aged 7 weeks were administered 12% fructose in their water and MET in distilled water or a diabetic nutrient mix (DNM) over 7 weeks. DNM-fed mice showed a decrease in systolic blood pressure, total cholesterol and fructosamine compared to the fructose-fed only group (p<0.05). A discordant result was observed in the MET group, with a decrease in blood pressure but increases in total cholesterol and fructosamine (p<0.05). Serum glucose did not change significantly among the groups. Thus, symptoms of fructose-induced MS in young mice could be countered nutritionally. Additionally, MET may improve certain biochemical markers while worsening others.
C1 [Cha, J. C.; Ivanov, V.; Roomi, M. W.; Kalinovsky, T.; Niedzwiecki, A.; Rath, M.] Dr Rath Res Inst, Santa Clara, CA 95050 USA.
RP Niedzwiecki, A (corresponding author), Dr Rath Res Inst, 1260 Memorex Dr, Santa Clara, CA 95050 USA.
EM author@drrath.com
OI Cha, John/0000-0003-2710-7476
FU Dr Rath Health Foundation (Plantation, FL, USA)
FX This study was funded by the Dr Rath Health Foundation (Plantation, FL,
   USA), a non-profit organization.
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NR 34
TC 1
Z9 2
U1 0
U2 4
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1791-2997
J9 MOL MED REP
JI Mol. Med. Rep.
PD NOV-DEC
PY 2011
VL 4
IS 6
BP 1053
EP 1059
DI 10.3892/mmr.2011.562
PG 7
WC Oncology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Research & Experimental Medicine
GA 826XR
UT WOS:000295389400003
PM 21874237
OA Bronze
DA 2025-06-11
ER

PT J
AU Maksyutynska, K
   Stogios, N
   Prasad, F
   Gill, J
   Hamza, Z
   De, R
   Smith, E
   Horta, A
   Goldstein, BI
   Korczak, D
   Graff-Guerrero, A
   Hahn, MK
   Agarwal, SM
AF Maksyutynska, Kateryna
   Stogios, Nicolette
   Prasad, Femin
   Gill, Jashan
   Hamza, Zaineb
   De, Riddhita
   Smith, Emily
   Horta, Angelina
   Goldstein, Benjamin I.
   Korczak, Daphne
   Graff-Guerrero, Ariel
   Hahn, Margaret K.
   Agarwal, Sri Mahavir
TI Neurocognitive correlates of metabolic dysregulation in individuals with
   mood disorders: a systematic review and meta-analysis
SO PSYCHOLOGICAL MEDICINE
LA English
DT Review
DE attention; bipolar disorder; cognition; diabetes; executive function;
   insulin resistance; major depressive disorder; memory; metabolic
   syndrome; mood disorders; obesity; processing speed
ID MAJOR DEPRESSIVE DISORDER; LATE-LIFE DEPRESSION; BIPOLAR I DISORDER;
   BODY-MASS INDEX; COGNITIVE IMPAIRMENT; INSULIN-RESISTANCE; EXECUTIVE
   FUNCTION; DIABETES-MELLITUS; OLDER-ADULTS; ASSOCIATION
AB Individuals with mood disorders are predisposed to metabolic dysfunction, while those with metabolic dysregulation such as diabetes and obesity experience more severe depressive symptoms. Both metabolic dysfunction and mood disorders are independently associated with cognitive deficits. Therefore, given their close association, this study aimed to explore the association between metabolic dysfunction in individuals with mood disorders in relation to cognitive outcomes. A comprehensive search comprised of these three domains was carried out; a random-effects meta-analysis pooling mean cognitive outcomes was conducted (PROSPERO ID: CRD42022295765). Sixty-three studies were included in this review; 26 were synthesized in a quantitative meta-analysis. Comorbid metabolic dysregulation was associated with significantly lower global cognition among individuals with mood disorders. These trends were significant within each mood disorder subgroup, including major depressive disorder, bipolar disorder, and self-report depression/depressive symptoms. Type 2 diabetes was associated with the lowest cognitive performance in individuals with mood disorders, followed by peripheral insulin resistance, body mass index 25 kg/m(2), and metabolic syndrome. Significant reduction in scores was also observed among individual cognitive domains (in descending order) of working memory, attention, executive function, processing speed, verbal memory, and visual memory. These findings demonstrate the detrimental effects of comorbid metabolic dysfunction in individuals with mood disorders. Further research is required to understand the underlying mechanisms connecting mood disorders, metabolism, and cognition.
C1 [Maksyutynska, Kateryna; Stogios, Nicolette; Prasad, Femin; Gill, Jashan; Hamza, Zaineb; De, Riddhita; Smith, Emily; Horta, Angelina; Goldstein, Benjamin I.; Korczak, Daphne; Graff-Guerrero, Ariel; Hahn, Margaret K.; Agarwal, Sri Mahavir] Univ Toronto, Inst Med Sci, Toronto, ON, Canada.
   [Maksyutynska, Kateryna; Stogios, Nicolette; Prasad, Femin; De, Riddhita; Smith, Emily; Hahn, Margaret K.; Agarwal, Sri Mahavir] Ctr Addict & Mental Hlth, Schizophrenia Div, Toronto, ON, Canada.
   [Gill, Jashan] McMaster Univ, Fac Sci, Hamilton, ON, Canada.
   [Hamza, Zaineb; Horta, Angelina] McMaster Univ, Fac Hlth Sci, Hamilton, ON, Canada.
   [Goldstein, Benjamin I.; Korczak, Daphne; Graff-Guerrero, Ariel; Hahn, Margaret K.; Agarwal, Sri Mahavir] Univ Toronto, Dept Psychiat, Fac Med, Toronto, ON, Canada.
   [Goldstein, Benjamin I.] Ctr Addict & Mental Hlth, Ctr Youth Bipolar Disorder, Toronto, ON, Canada.
   [Goldstein, Benjamin I.] Univ Toronto, Dept Pharmacol & Toxicol, Toronto, ON, Canada.
   [Korczak, Daphne] Hosp Sick Children, Dept Psychiat, Toronto, ON, Canada.
   [Graff-Guerrero, Ariel] Res Imaging Ctr, Ctr Addict & Mental Hlth, Toronto, ON, Canada.
C3 University of Toronto; University of Toronto; Centre for Addiction &
   Mental Health - Canada; McMaster University; McMaster University;
   University of Toronto; University of Toronto; Centre for Addiction &
   Mental Health - Canada; University of Toronto; University of Toronto;
   Hospital for Sick Children (SickKids); University of Toronto; Centre for
   Addiction & Mental Health - Canada
RP Agarwal, SM (corresponding author), Univ Toronto, Inst Med Sci, Toronto, ON, Canada.; Agarwal, SM (corresponding author), Ctr Addict & Mental Hlth, Schizophrenia Div, Toronto, ON, Canada.; Agarwal, SM (corresponding author), Univ Toronto, Dept Psychiat, Fac Med, Toronto, ON, Canada.
EM Mahavir.Agarwal@camh.ca
RI Agarwal, Mahavir/ITV-3244-2023; Goldstein, Benjamin/ADR-2374-2022
OI De, Riddhita/0000-0002-8953-4716; Stogios, Nicolette/0000-0001-9136-4923
FU Department of Psychiatry, University of Toronto; CAMH Discovery Fund
FX The authors would like to thank Dr Van Rheenen et al., Dr Hubenak et
   al., and Dr Geraets et al. for providing additional information to
   synthesize in this review. S. M. A. is supported by in part by an
   Academic Scholars Award from the Department of Psychiatry, University of
   Toronto and the CAMH Discovery Fund. B. I. G. acknowledges his position
   as RBC Investments Chair in Children's Mental Health and Developmental
   Psychopathology at CAMH, a joint Hospital-University Chair between the
   University of Toronto, CAMH, and the CAMH Foundation.
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NR 92
TC 7
Z9 7
U1 6
U2 21
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0033-2917
EI 1469-8978
J9 PSYCHOL MED
JI Psychol. Med.
PD MAY
PY 2024
VL 54
IS 7
BP 1245
EP 1271
DI 10.1017/S0033291724000345
PG 27
WC Psychology, Clinical; Psychiatry; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA 2XY2K
UT WOS:001493962600001
PM 38450447
OA hybrid
DA 2025-06-11
ER

PT J
AU Gallagher, D
   Kiss, A
   Lanctot, K
   Herrmann, N
AF Gallagher, Damien
   Kiss, Alex
   Lanctot, Krista
   Herrmann, Nathan
TI Depressive symptoms and cognitive decline: A longitudinal analysis of
   potentially modifiable risk factors in community dwelling older adults
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Depression; Older age; Inflammation; Cognition; Physical activity;
   Vascular risk factors
ID ALZHEIMERS-DISEASE; NEUROTROPHIC FACTOR; METABOLIC SYNDROME;
   PHYSICAL-ACTIVITY; DEMENTIA; INFLAMMATION; METAANALYSIS; IMPAIRMENT;
   EXERCISE; INCREASE
AB Background: Depressive symptoms have been associated with increased risk of cognitive decline in later life. There are no interventions proven to reduce risk of cognitive decline in older adults with depression, and it is unclear how these effects are mediated. We aim to determine what mediates the relationship between depressive symptoms and cognitive decline in later life.
   Methods: Seven thousand six hundred and sixty six community dwelling older adults (age >= 50) from the English Longitudinal study of Ageing (ELSA) underwent clinical assessment. Inflammation was assessed with C Reactive Protein and depressive symptoms were assessed with the 8-item version of the Center for Epidemiologic Studies (CESD) scale.
   Results: Five thousand, five hundred and ninety (73.5%) had a follow-up cognitive assessment after a median of 47 months. Depressive symptoms were independently associated with cognitive decline (B=0.09, p < 0.001). Low physical activity, inflammation, metabolic syndrome and vascular risk factors were associated with elevated depressive symptoms. Low physical activity (z=2.16, p=0.03) and inflammation (z=2.3, p=0.02) mediated the relationship between depressive symptoms and cognitive decline while hypertension, diabetes and smoking also contributed.
   Limitations: This is an observational study with a limited duration of follow up. Not all variables related to cognitive decline were accounted for in this analysis.
   Conclusions: The relationship between depressive symptoms and cognitive decline in later life appears to be mediated by low physical activity, increased inflammation and vascular risk factors that may be amenable to modification. (C) 2015 Published by Elsevier B.V.
C1 [Gallagher, Damien; Herrmann, Nathan] Sunnybrook Hlth Sci Ctr, Div Geriatr Psychiat, Toronto, ON M4N 3M5, Canada.
   [Gallagher, Damien; Herrmann, Nathan] Univ Toronto, Toronto, ON M5S 1A1, Canada.
   [Kiss, Alex; Lanctot, Krista] Univ Toronto, Sunnybrook Res Inst, Toronto, ON M5S 1A1, Canada.
   [Kiss, Alex] Univ Toronto, Dept Hlth Policy Management & Evaluat, Toronto, ON M5S 1A1, Canada.
   [Lanctot, Krista] Univ Toronto, Dept Psychiat, Toronto, ON M5S 1A1, Canada.
   [Lanctot, Krista] Univ Toronto, Dept Pharmacol, Toronto, ON M5S 1A1, Canada.
   [Lanctot, Krista] Univ Toronto, Dept Toxicol, Toronto, ON M5S 1A1, Canada.
C3 University of Toronto; Sunnybrook Health Science Center; Sunnybrook
   Research Institute; University of Toronto; University of Toronto;
   Sunnybrook Health Science Center; Sunnybrook Research Institute;
   University of Toronto; University of Toronto; University of Toronto;
   University of Toronto
RP Gallagher, D (corresponding author), Sunnybrook Hlth Sci Ctr, 2075 Bayview Ave, Toronto, ON M4N 3M5, Canada.
EM Damien.gallagher@sunnybrook.ca
RI Lanctot, Krista/AAY-4820-2020
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NR 48
TC 62
Z9 69
U1 3
U2 36
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD JAN 15
PY 2016
VL 190
BP 235
EP 240
DI 10.1016/j.jad.2015.09.046
PG 6
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA CY5QT
UT WOS:000366463000035
PM 26521086
DA 2025-06-11
ER

PT J
AU Di Franco, A
   Lanza, GA
   Di Monaco, A
   Sestito, A
   Lamendola, P
   Nerla, R
   Tarzia, P
   Virdis, D
   Vollono, C
   Valeriani, M
   Crea, F
AF Di Franco, Antonino
   Lanza, Gaetano A.
   Di Monaco, Antonio
   Sestito, Alfonso
   Lamendola, Priscilla
   Nerla, Roberto
   Tarzia, Pierpaolo
   Virdis, Daniela
   Vollono, Catello
   Valeriani, Massimiliano
   Crea, Filippo
TI Coronary Microvascular Function and Cortical Pain Processing in Patients
   With Silent Positive Exercise Testing and Normal Coronary Arteries
SO AMERICAN JOURNAL OF CARDIOLOGY
LA English
DT Article
ID CARDIAC SYNDROME-X; ANGINA-PECTORIS; CHEST-PAIN; MYOCARDIAL-ISCHEMIA;
   HEART-DISEASE; DYSFUNCTION; ANGIOGRAMS; SCINTIGRAPHY; SENSITIVITY;
   MORTALITY
AB ST-segment depression during exercise stress testing in asymptomatic subjects showing normal coronary arteries is considered a "false-positive" result. Coronary microvascular dysfunction, however, might be a possible cause of ST-segment depression in these cases. We assessed the coronary blood flow response to adenosine and to cold pressor test in the left anterior descending artery, using transthoracic Doppler echocardiography in 14 asymptomatic subjects with exercise-induced ST-segment depression and normal coronary arteries (group 1), 14 patients with microvascular angina (group 2), and 14 healthy subjects (group 3). Flow-mediated dilation was assessed in the brachial artery. Central pain processing was assessed using cortical laser evoked potentials during chest and right hand stimulation with 3 sequences of painful stimuli. The coronary blood flow response to adenosine was 1.8 +/- 0.4, 1.9 +/- 0.5, and 3.1 +/- 0.9 in groups 1, 2, and 3, respectively (p <0.001). The corresponding coronary blood flow responses to the cold pressor test were 1.74 +/- 0.4, 1.53 +/- 0.3, and 2.3 +/- 0.6 (p <0.001). The flow-mediated dilation was 5.5 +/- 2.3%, 4.6 +/- 2.4%, and 9.8 +/- 1.2% in the 3 groups, respectively (p <0.001). The laser evoked potential N2/P2 wave amplitude decreased throughout the 3 sequences of stimulation in groups 1 and 3 but not in group 2 (chest, -19 +/- 22%, +11 +/- 42% and -36 +/- 12%, p <0.001; right hand, -22 +/- 25%, +12 +/- 43% and -30 +/- 20%, p = 0.009; in groups 1, 2, and 3). In conclusion, exercise stress test-induced ST-segment depression in asymptomatic subjects with normal coronary arteries cannot be considered as a simple false-positive result, because it can be related to coronary microvascular dysfunction. The different symptomatic state compared to patients with microvascular angina can, at least in part, be explained by differences in cortical processing of neural pain stimuli. (C) 2012 Elsevier Inc. All rights reserved. (Am J Cardiol 2012;109:1705-1710)
C1 [Di Franco, Antonino; Lanza, Gaetano A.; Di Monaco, Antonio; Sestito, Alfonso; Lamendola, Priscilla; Nerla, Roberto; Tarzia, Pierpaolo; Crea, Filippo] Univ Cattolica Sacro Cuore, Inst Cardiol, Rome, Italy.
   [Virdis, Daniela; Vollono, Catello; Valeriani, Massimiliano] Univ Cattolica Sacro Cuore, Inst Neurol, Rome, Italy.
C3 Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli;
   Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli
RP Lanza, GA (corresponding author), Univ Cattolica Sacro Cuore, Inst Cardiol, Rome, Italy.
EM g.a.lanza@rm.unicatt.it
RI Tarzia, Pierpaolo/AAC-1593-2019; Vollono, Catello/AAU-7072-2021; Nerla,
   Roberto/AAL-1534-2020; Crea, Filippo/AAC-9754-2022; Valeriani,
   Massimiliano/AAA-4459-2020; Lanza, Gaetano/AAC-2660-2019; Valeriani,
   Massimiliano/K-5736-2016; Di monaco, Antonio/AAR-8825-2021
OI Vollono, Catello/0000-0001-9371-8035; Valeriani,
   Massimiliano/0000-0001-6602-103X; Di monaco,
   Antonio/0000-0002-1297-2056; Nerla, Roberto/0000-0002-9065-3261
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NR 30
TC 14
Z9 14
U1 0
U2 2
PU EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
PI BRIDGEWATER
PA 685 ROUTE 202-206 STE 3, BRIDGEWATER, NJ 08807 USA
SN 0002-9149
EI 1879-1913
J9 AM J CARDIOL
JI Am. J. Cardiol.
PD JUN 15
PY 2012
VL 109
IS 12
BP 1705
EP 1710
DI 10.1016/j.amjcard.2012.02.012
PG 6
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 964XE
UT WOS:000305729200004
PM 22459303
DA 2025-06-11
ER

PT J
AU Prinsloo, GE
   Rauch, HGL
   Derman, WE
AF Prinsloo, Gabriell E.
   Rauch, H. G. Laurie
   Derman, Wayne E.
TI A Brief Review and Clinical Application of Heart Rate Variability
   Biofeedback in Sports, Exercise, and Rehabilitation Medicine
SO PHYSICIAN AND SPORTSMEDICINE
LA English
DT Review
DE noncommunicable disease; psychosocial stress; heart rate variability;
   biofeedback
ID RESPIRATORY-SINUS-ARRHYTHMIA; POWER SPECTRAL-ANALYSIS; INDUCED
   MYOCARDIAL-ISCHEMIA; FREQUENCY-DOMAIN ANALYSIS; PSYCHOSOCIAL
   RISK-FACTORS; METABOLIC-SYNDROME; BLOOD-PRESSURE; BAROREFLEX
   SENSITIVITY; MENTAL STRESS; JOB STRAIN
AB Context: An important component of the effective management of chronic noncommunicable disease is the assessment and management of psychosocial stress. The measurement and modulation of heart rate variability (HRV) may be valuable in this regard. Objective: To describe the measurement and physiological control of HRV; to describe the impact of psychosocial stress on cardiovascular disease, metabolic syndrome, and chronic respiratory disease, and the relationship between these diseases and changes in HRV; and to describe the influence of biofeedback and exercise on HRV and the use of HRV biofeedback in the management of chronic disease. Data Sources and Study Selection: The PubMed, Medline, and Embase databases were searched (up to August 2013). Additional articles were obtained from the reference lists of relevant articles and reviews. Articles were individually selected for further review based on the quality and focus of the study, and the population studied. Results: Heart rate variability is reduced in stress and in many chronic diseases, and may even predict the development and prognosis of some diseases. Heart rate variability can be increased with both exercise and biofeedback. Although the research on the effect of exercise is conflicting, there is evidence that aerobic training may increase HRV and cardiac vagal tone both in healthy individuals and in patients with disease. Heart rate variability biofeedback is also an effective method of increasing HRV and cardiac vagal tone, and has been shown to decrease stress and reduce the morbidity and mortality of disease. Conclusion: The assessment and management of psychosocial stress is a challenging but important component of effective comprehensive lifestyle interventions for the management of noncommunicable disease. It is, therefore, important for the sports and exercise physician to have an understanding of the therapeutic use of HRV modulation, both in the reduction of stress and in the management of chronic disease.
C1 [Prinsloo, Gabriell E.; Rauch, H. G. Laurie; Derman, Wayne E.] Univ Cape Town, MRC, UCT Res Unit Exercise Sci & Sports Med, ZA-7725 Cape Town, South Africa.
   [Prinsloo, Gabriell E.; Derman, Wayne E.] IOC Res Ctr, Cape Town, South Africa.
C3 University of Cape Town
RP Prinsloo, GE (corresponding author), Univ Cape Town, Fac Hlth Sci, Dept Human Biol, MRC UCT Res Unit Exercise Sci & Sports Med, POB 115, ZA-7725 Cape Town, South Africa.
EM gabriellprinsloo@gmail.com
RI Derman, Wayne/ABD-6557-2020; Rauch, HG Laurie/HCI-8272-2022
OI Rauch, HG Laurie/0000-0002-7709-3407
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NR 164
TC 72
Z9 87
U1 2
U2 84
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0091-3847
EI 2326-3660
J9 PHYSICIAN SPORTSMED
JI Physician Sportsmed.
PD MAY
PY 2014
VL 42
IS 2
BP 88
EP 99
DI 10.3810/psm.2014.05.2061
PG 12
WC Primary Health Care; Orthopedics; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine; Orthopedics; Sport Sciences
GA AR2FM
UT WOS:000343399000009
PM 24875976
DA 2025-06-11
ER

PT J
AU Chueakula, N
   Jaikumkao, K
   Arjinajarn, P
   Pongchaidecha, A
   Chatsudthipong, V
   Chattipakorn, N
   Lungkaphin, A
AF Chueakula, Nuttawud
   Jaikumkao, Krit
   Arjinajarn, Phatchawan
   Pongchaidecha, Anchalee
   Chatsudthipong, Varanuj
   Chattipakorn, Nipon
   Lungkaphin, Anusorn
TI Diacerein alleviates kidney injury through attenuating inflammation and
   oxidative stress in obese insulin-resistant rats
SO FREE RADICAL BIOLOGY AND MEDICINE
LA English
DT Article
DE Diacerein; Inflammation; Insulin resistance; Kidney function; Oxidative
   stress
ID ORGANIC ION TRANSPORTERS; HIGH-FAT DIET; METABOLIC SYNDROME;
   ADIPOSE-TISSUE; HYDROGEN-PEROXIDE; ANGIOTENSIN-II; RENAL-FUNCTION;
   DISEASE; EXPRESSION; DIACERHEIN
AB A link between inflammation with obesity and metabolic syndrome has been found in patients with chronic kidney disease (CKD). Diacerein is an anthraquinone used to treat osteoarthritis that exerts anti-inflammatory action by inhibiting the synthesis and activity of proinflammatory cytokines. This study aimed to investigate the protective effect of diacerein on renal function and renal organic anion transporter 3 (Oat3) function in obese insulin-resistant condition. Obese insulin-resistant rats were induced by feeding a high-fat diet in male Wistar rats for 16 weeks. Diacerein or metformin (positive control) (30 mg/kg/day) was administered orally for 4 weeks after insulin resistance had been confirmed. Obese insulin-resistant rats showed an impaired renal function as indicated by the increased serum creatinine and microalbuminuria along with the decreased renal Oat3 function and expression. Importantly, diacerein treatment not only improved insulin resistance but also restored renal function. The decreased renal malondialdehyde level, expressions of PKC alpha, angiotensin 1 receptor (AT1R), Nrf2, and HO-1, and increased expression of SOD2 were observed in diacerein treatment group, indicating the attenuation of renal oxidative stress condition. Moreover, renal inflammation and renal damage were also alleviated in diacerein-treated rats. Our results demonstrated for the first time that diacerein was effective to improve renal function and renal Oat3 function in obese insulin-resistance condition mediated by suppressing renal oxidative stress and inflammation. These findings suggest that anti-inflammatory agents can be used therapeutically to improve metabolic disorder and prevent organ dysfunctions in pre-diabetic condition.
C1 [Chueakula, Nuttawud; Jaikumkao, Krit; Pongchaidecha, Anchalee; Chattipakorn, Nipon; Lungkaphin, Anusorn] Chiang Mai Univ, Dept Physiol, Fac Med, Chiang Mai 50200, Thailand.
   [Arjinajarn, Phatchawan] Chiang Mai Univ, Dept Biol, Fac Sci, Chiang Mai, Thailand.
   [Chatsudthipong, Varanuj] Mahidol Univ, Dept Physiol, Fac Sci, Bangkok, Thailand.
   [Chattipakorn, Nipon] Chiang Mai Univ, Cardiac Electrophysiol Res & Training Ctr, Fac Med, Chiang Mai, Thailand.
C3 Chiang Mai University; Chiang Mai University; Mahidol University; Chiang
   Mai University
RP Lungkaphin, A (corresponding author), Chiang Mai Univ, Dept Physiol, Fac Med, Chiang Mai 50200, Thailand.
EM onanusorn@yahoo.com
RI Jaikumkao, Krit/IUN-9587-2023; ARJINAJARN, PHATCHAWAN/GNM-8700-2022;
   Chattipakorn, Nipon/AAJ-4049-2021
OI Chattipakorn, Nipon/0000-0003-3026-718X
FU Thailand Research Fund [RSA6080015]; Faculty of Medicine Research Fund,
   Chiang Mai University [041-2561]; Center for Research and Development of
   Natural Products for Health; NSTDA Research Chair grant from the
   National Science and Technology Development Agency of Thailand
FX This work was supported by the Thailand Research Fund (RSA6080015) (AL),
   the Faculty of Medicine Research Fund, Chiang Mai University (041-2561)
   (AL and AP), Center for Research and Development of Natural Products for
   Health, and the NSTDA Research Chair grant from the National Science and
   Technology Development Agency of Thailand (NC).
CR [Anonymous], COCHRANE DATABASE SY
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NR 67
TC 45
Z9 46
U1 0
U2 28
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0891-5849
EI 1873-4596
J9 FREE RADICAL BIO MED
JI Free Radic. Biol. Med.
PD FEB 1
PY 2018
VL 115
BP 146
EP 155
DI 10.1016/j.freeradbiomed.2017.11.021
PG 10
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA FS3UN
UT WOS:000419709200014
PM 29195834
DA 2025-06-11
ER

PT J
AU Al-Hawary, SIS
   Alzahrani, AA
   Maabreh, HG
   Jawad, MA
   Alsaadi, SB
   Jabber, NK
   Alawadi, A
   Alsalamy, A
   Alizadeh, F
AF Al-Hawary, Sulieman Ibraheem Shelash
   Alzahrani, Abdullah Ali
   Maabreh, Hatem Ghaleb
   Jawad, Mohammed Abed
   Alsaadi, Salim B.
   Jabber, Noura Kareem
   Alawadi, Ahmed
   Alsalamy, Ali
   Alizadeh, Farideh
TI The association of metabolic syndrome with telomere length as a marker
   of cellular aging: a systematic review and meta-analysis
SO FRONTIERS IN GENETICS
LA English
DT Review
DE metabolic syndrome; telomere length; telomerase; aging; meta-analysis
ID PHYSICAL-ACTIVITY; OXIDATIVE STRESS; COMPONENTS; DISEASE; OBESITY; RISK
AB Background: It has been suggested that metabolic syndrome (MetS) accelerates the aging process, potentially contributing to the development of age-related complications. Available studies examining the relation of MetS to telomere length (TL), a putative biological marker of aging, have yielded inconclusive findings. This meta-analysis was performed to investigate the association between MetS and TL. Methods: A comprehensive systematic search was conducted in PubMed and Scopus databases to identify relevant literature published up to February 2024. Standard mean difference (SMD) and standardized beta coefficient (beta) with their 95% confidence intervals (CI) were used as effect sizes to measure the associations using the random effects model. Results: A total of nine studies, comprising a total sample size of 8,606 participants, were eligible for the meta-analysis. No significant difference in mean TL was found between patients with and without MetS (SMD = -0.03, 95%CI = -0.17 to 0.10), with a significant heterogeneity across the studies (I-2 = 89.7.0%, p <= 0.001). In contrast, it was revealed that MetS is negatively related to TL (beta = -0.08, 95%CI = -0.15 to -0.004). In the subgroup analysis, this finding was supported by the International Diabetes Federation (IDF) definition of MetS. Conclusion: This meta-analysis highlighted that MetS may be linked to a shorter TL. Additional studies are required to confirm this finding.
C1 [Al-Hawary, Sulieman Ibraheem Shelash] Al Al Bayt Univ, Business Sch, Dept Business Adm, Mafraq, Jordan.
   [Alzahrani, Abdullah Ali] Taif Univ, Dept Surg, Taif, Saudi Arabia.
   [Maabreh, Hatem Ghaleb] RUDN Univ, Patrice Lumumba Peoples Friendship Univ Russia, Dept Dermatovenerol Foreign Languages, Moscow, Russia.
   [Jawad, Mohammed Abed] Al Nisour Univ Coll, Dept Pharmaceut, Baghdad, Iraq.
   [Alsaadi, Salim B.] Al Hadi Univ Coll, Dept Pharmaceut, Baghdad, Iraq.
   [Jabber, Noura Kareem] Al Ayen Univ, Coll Hlth & Med Technol, Nasiriyah, Iraq.
   [Alawadi, Ahmed] Islamic Univ, Coll Tech Engn, Najaf, Iraq.
   [Alawadi, Ahmed] Islamic Univ Al Diwaniyah, Coll Tech Engn, Al Diwaniyah, Iraq.
   [Alawadi, Ahmed] Islamic Univ Babylon, Coll Tech Engn, Babylon, Iraq.
   [Alsalamy, Ali] Imam Jaafar Al Sadiq Univ, Coll Tech Engn, Samawah, Iraq.
   [Alizadeh, Farideh] Univ Tehran Med Sci, Dept Med, Tehran, Iran.
C3 Al al-Bayt University; Taif University; Peoples Friendship University of
   Russia; Al-Nisour University College; Al-Ayen University; Islamic
   University College; University of Babylon; Imam Jaa'far al-Sadiq
   University; Tehran University of Medical Sciences
RP Alizadeh, F (corresponding author), Univ Tehran Med Sci, Dept Med, Tehran, Iran.
EM farabora2022@gmail.com
RI Al-Hawary, Sulieman/B-3115-2013
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NR 55
TC 1
Z9 1
U1 0
U2 3
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1664-8021
J9 FRONT GENET
JI Front. Genet.
PD JUL 9
PY 2024
VL 15
AR 1390198
DI 10.3389/fgene.2024.1390198
PG 11
WC Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Genetics & Heredity
GA ZH3V1
UT WOS:001274375100001
PM 39045323
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Montoya-Alatriste, CA
   Alarcon-Aguilar, FJ
AF Ali Montoya-Alatriste, Claudia
   Javier Alarcon-Aguilar, Francisco
TI Cannabis and cannabinoids as an alternative remedy in metabolic
   syndrome
SO BRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCES
LA English
DT Article
DE Cannabis; Cannabinoids; Metabolic syndrome; CB1 antagonists;
   Cannabidiol; Diabetes mellitus
ID ENDOCANNABINOID SYSTEM; DIABETES-MELLITUS; OXIDATIVE STRESS; MARIJUANA
   USE; RECEPTOR; INSULIN; GLUCOSE; CB1; EXPRESSION; SECRETION
AB Metabolic syndrome (MetS), an epidemic defined as a group of interconnected physiological, biochemistry, clinical, and metabolic factors, directly increases the risk of cardiovascular disease, atherosclerosis, type 2 diabetes, and death. MetS therapy includes diet, physical exercise, and a poly-pharmacological intervention. Cannabis is mainly recognized for its recreational uses and has several medical applications for neurological diseases, due to its hypnotic, anxiolytic, antinociceptive, anti-inflammatory, and anticonvulsant activities. Although several clinical observations in Cannabis smokers suggest metabolic effects, its utility in metabolic disorders is unclear. This review aims to determine under what conditions Cannabis might be useful in the treatment of MetS. Cannabis contains 120 phytocannabinoids, of which Delta(9)-THC mediates its psychoactive effects. Cannabinoids exert biological effects through interactions with the endocannabinoid system, which modulates several physiologic and metabolic pathways through cannabinoid receptors (CB1/CB2). Signaling through both receptors inhibits neurotransmitter release. In general, endocannabinoid system stimulation in Cannabis smokers and Delta(9)-THC signaling through CB1 have been implicated in MetS development, obesity, and type 2 diabetes. In contrast, CB1 antagonists and non-psychotropic phytocannabinoids like cannabidiol reduce these effects through interactions with both cannabinoid and non-cannabinoid receptors. These pharmacological approaches represent a source of new therapeutic agents for MetS. However, more studies are necessary to support the therapeutic potential of Cannabis and cannabinoids in metabolic abnormalities.
C1 [Ali Montoya-Alatriste, Claudia; Javier Alarcon-Aguilar, Francisco] Univ Autonoma Metropolitana Iztapalapa, Lab Farmacol, Dept Ciencias Salud, Div Ciencias Biol Salud, Ciudad De Mexico, Mexico.
C3 Universidad Autonoma Metropolitana - Mexico
RP Alarcon-Aguilar, FJ (corresponding author), Dept Ciencias Salud, Lab Farmacol, Div Ciencias Biol Salud, Linidad Iztapalapa, Av San Rafael Atlixco 186,Ap Postal 55-535, Cdmx 09340, Mexico.
EM aaasj2@prodigy.net.mx
FU National Council for Science and Technology (CONACYT) [17057];
   PRODEP-SEP
FX This study was supported by the National Council for Science and
   Technology (CONACYT) under Grant 17057 (CAMA) and PRODEP-SEP.
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NR 106
TC 5
Z9 5
U1 2
U2 8
PU UNIV SAO PAULO, CONJUNTO QUIMICAS
PI SAO PAULO
PA SERVICO PUBLICACOES E CIRCULACAO, CAIXA POSTAL 66083, SAO PAULO, 00000,
   BRAZIL
SN 1984-8250
EI 2175-9790
J9 BRAZ J PHARM SCI
JI Braz. J. Pharm. Sci.
PY 2022
VL 58
AR e20161
DI 10.1590/s2175-97902022e20161
PG 23
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 6E7RS
UT WOS:000883573800001
OA gold
DA 2025-06-11
ER

PT J
AU Mendez, L
   Dasilva, G
   Taltavull, NR
   Romeu, M
   Medina, I
AF Mendez, Lucia
   Dasilva, Gabriel
   Taltavull, Nuria
   Romeu, Marta
   Medina, Isabel
TI Marine Lipids on Cardiovascular Diseases and Other Chronic Diseases
   Induced by Diet: An Insight Provided by Proteomics and Lipidomics
SO MARINE DRUGS
LA English
DT Review
DE marine lipids; EPA; DHA; proteomics; lipidomics; metabolic syndrome;
   cardiovascular disease; type 2 diabetes
ID N-3 FATTY-ACID; FISH-OIL SUPPLEMENTATION; METABOLIC SYNDROME; OXIDATIVE
   STRESS; ADIPOSE-TISSUE; DOCOSAHEXAENOIC ACID; INSULIN-RESISTANCE;
   OMEGA-3 PUFAS; OMEGA-3-FATTY-ACID SUPPLEMENTATION; EICOSAPENTAENOIC ACID
AB Marine lipids, especially omega-3 polyunsaturated fatty acids (PUFAs) eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), have largely been linked to prevention of diet-induced diseases. The anti-inflammatory and hypolipidemic properties of EPA and DHA supplementation have been well-described. However, there is still a significant lack of information about their particular mechanism of action. Furthermore, repeated meta-analyses have not shown conclusive results in support of their beneficial health effects. Modern "omics" approaches, namely proteomics and lipidomics, have made it possible to identify some of the mechanisms behind the benefits of marine lipids in the metabolic syndrome and related diseases, i.e., cardiovascular diseases and type 2 diabetes. Although until now their use has been scarce, these "omics" have brought new insights in this area of nutrition research. The purpose of the present review is to comprehensively show the research articles currently available in the literature which have specifically applied proteomics, lipidomics or both approaches to investigate the role of marine lipids intake in the prevention or palliation of these chronic pathologies related to diet. The methodology adopted, the class of marine lipids examined, the diet-related disease studied, and the main findings obtained in each investigation will be reviewed.
C1 [Mendez, Lucia; Dasilva, Gabriel; Medina, Isabel] Inst Invest Marinas IIM CSIC, Eduardo Cabello 6, E-36208 Vigo, Spain.
   [Taltavull, Nuria; Romeu, Marta] Univ Rovira & Virgili, Fac Med & Ciencies Salut, Unitat Farmacol, St Llorenc 21, E-43201 Reus, Spain.
C3 Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Instituto
   de Investigaciones Marinas (IIM); Universitat Rovira i Virgili
RP Mendez, L (corresponding author), Inst Invest Marinas IIM CSIC, Eduardo Cabello 6, E-36208 Vigo, Spain.
EM luciamendez@iim.csic.es; gabrielsilva@iim.csic.es;
   nuria.taltavull@urv.cat; marta.romeu@urv.cat; medina@iim.csic.es
RI ROMEU, MARTA/O-7129-2019; MEDINA, ISABEL/AAL-4012-2021; Mendez,
   Lucia/T-7016-2017; ROMEU, MARTA/A-8468-2014
OI Mendez, Lucia/0000-0002-9711-2994; MEDINA, ISABEL/0000-0002-1854-3359;
   ROMEU, MARTA/0000-0002-2131-1858
FU Spanish Ministry of Science and Innovation [AGL2013-49079-C2-1-R];
   Consejo Superior de Investigaciones Cientificas (CSIC); University of
   Santiago de Compostela (USC)
FX Spanish Ministry of Science and Innovation is acknowledged for grant
   AGL2013-49079-C2-1-R. The Consejo Superior de Investigaciones
   Cientificas (CSIC) and the University of Santiago de Compostela (USC)
   are gratefully acknowledged for the doctoral fellowship to G.D. Language
   revision by Hannelore Lott is appreciated.
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NR 81
TC 17
Z9 19
U1 3
U2 28
PU MDPI AG
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1660-3397
J9 MAR DRUGS
JI Mar. Drugs
PD AUG
PY 2017
VL 15
IS 8
AR 258
DI 10.3390/md15080258
PG 29
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA FF2YT
UT WOS:000408763400023
PM 28820493
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Oliveira, PS
   Chaves, VC
   Bona, NP
   Soares, MSP
   Cardoso, JD
   Vasconcellos, FA
   Tavares, RG
   Vizzotto, M
   da Silva, LMC
   Grecco, FB
   Gamaro, GD
   Spanevello, RM
   Lencina, CL
   Reginatto, FH
   Stefanello, FM
AF Oliveira, Pathise Souto
   Chaves, Vitor Clasen
   Bona, Natalia Pontes
   Pereira Soares, Mayara Sandrielly
   Cardoso, Juliane de Souza
   Vasconcellos, Flavia Aleixo
   Tavares, Rejane Giacomelli
   Vizzotto, Marcia
   Cerqueira da Silva, Luisa Mariano
   Grecco, Fabiane Borelli
   Gamaro, Giovana Duzzo
   Spanevello, Roselia Maria
   Lencina, Claiton Leoneti
   Reginatto, Flavio Henrique
   Stefanello, Francieli Moro
TI Eugenia uniflora fruit (red type) standardized extract: a
   potential pharmacological tool to diet-induced metabolic syndrome damage
   management
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Article
DE Metabolic syndrome; Eugenia uniflora; Phenolic compounds;
   Pharmacological management
ID OXIDATIVE STRESS; ANTIINFLAMMATORY PROPERTIES; INSULIN-RESISTANCE;
   RAT-BRAIN; ACETYLCHOLINESTERASE; HIPPOCAMPUS; POLYPHENOLS; EXPRESSION;
   LEAVES; MODEL
AB The aim of this study was to investigate the effect of Eugenia uniflora fruit (red type) extract on metabolic status, as well as on neurochemical and behavioral parameters in an animal model of metabolic syndrome induced by a highly palatable diet (HPD). Rats were treated for 150 days and divided into 4 experimental groups: standard chow (SC) and water orally, SC and E. uniflora extract (200 mg/kg daily, p. o), HPD and water orally, HPD and extract. Our data showed that HPD caused glucose intolerance, increased visceral fat, weight gain, as well as serum glucose, triacylglycerol, total cholesterol and LDL cholesterol; however, E. uniflora prevented these alterations. The extract decreased lipid peroxidation and prevented the reduction of superoxide dismutase and catalase activities in the prefrontal cortex, hippocampus and striatum of animals submitted to HPD. We observed a HPD-induced reduction of thiol content in these cerebral structures. The extract prevented increased acetylcholinesterase activity in the prefrontal cortex caused by HPD and the increase in immobility time observed in the forced swim test. Regarding chemical composition, LC/MS analysis showed the presence of nine anthocyanins as the major compounds. In conclusion, E. uniflora extract showed benefits against metabolic alterations caused by HPD, as well as exhibited antioxidant and antidepressant-like effects. (C) 2017 Published by Elsevier Masson SAS.
C1 [Oliveira, Pathise Souto; Bona, Natalia Pontes; Cardoso, Juliane de Souza; Tavares, Rejane Giacomelli; Lencina, Claiton Leoneti; Stefanello, Francieli Moro] Univ Fed Pelotas, Ctr Ciencias Quim Farmaceut & Alimentos, Lab Biomarcadores, Campus Univ S-N, Pelotas, RS, Brazil.
   [Chaves, Vitor Clasen; Reginatto, Flavio Henrique] Univ Fed Santa Catarina, Programa Posgrad Biotecnol & Biociencias, Lab Farmacognosia, Florianopolis, SC, Brazil.
   [Pereira Soares, Mayara Sandrielly; Gamaro, Giovana Duzzo; Spanevello, Roselia Maria] Univ Fed Pelotas, Ctr Ciencias Quim Farmaceut & Alimentos, Lab Neuroquim Inflamacao & Canc, Campus Univ S-N, Pelotas, RS, Brazil.
   [Vasconcellos, Flavia Aleixo] Univ Fed Pelotas, Ctr Ciencias Quim Farmaceut & Alimentos, Lab Quim Aplicada Bioat, Campus Univ S-N, Pelotas, RS, Brazil.
   [Vizzotto, Marcia] Empresa Brasileira Pesquisa Agr, Ctr Pesquisa Agr Clima Temp, Pelotas, RS, Brazil.
   [Cerqueira da Silva, Luisa Mariano; Grecco, Fabiane Borelli] Univ Fed Pelotas, Programa Posgrad Vet, Lab Patol Anim, Campus Univ S-N, Pelotas, RS, Brazil.
C3 Universidade Federal de Pelotas; Universidade Federal de Santa Catarina
   (UFSC); Universidade Federal de Pelotas; Universidade Federal de
   Pelotas; Empresa Brasileira de Pesquisa Agropecuaria (EMBRAPA);
   Universidade Federal de Pelotas
RP Stefanello, FM (corresponding author), Univ Fed Pelotas, Campus Univ S-N, BR-96160000 Capao Do Leao, RS, Brazil.; Reginatto, FH (corresponding author), Univ Fed Santa Catarina, Florianopolis, SC, Brazil.
EM flavio.reginatto@ufsc.br; francieli.stefanelo@ufpel.edu.br
RI Vasconcellos, F/E-4773-2016; Oliveira, Ronaldo/X-1597-2019; Spanevello,
   Roselia/H-1610-2018; Tavares, Rejane/C-1307-2010; Gamaro,
   Giovana/G-8868-2018
OI Gamaro, Giovana/0000-0002-1674-1693; Giacomelli Tavares,
   Rejane/0000-0002-9806-1893; VIERA OLIVEIRA,
   PATRICIA/0000-0003-2155-6262; REGINATTO, FLAVIO/0000-0002-4710-8540;
   Cardoso, Juliane/0000-0002-2726-4159; Spanevello,
   Roselia/0000-0002-5117-2000
FU FAPERGS; CAPES; CNPq
FX The Brazilian research funding agencies FAPERGS, CAPES and CNPq
   supported this study. The authors thank Hedy Hofmann for the English
   review.
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NR 47
TC 28
Z9 29
U1 1
U2 25
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD AUG
PY 2017
VL 92
BP 935
EP 941
DI 10.1016/j.biopha.2017.05.131
PG 7
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA FE0MY
UT WOS:000407915600105
PM 28618655
OA Green Published
DA 2025-06-11
ER

PT J
AU Won, JC
   Park, CY
   Oh, SW
   Lee, ES
   Youn, BS
   Kim, MS
AF Won, Jong Chul
   Park, Cheol-Young
   Oh, Sang Woo
   Lee, Eon Sook
   Youn, Byung-Soo
   Kim, Min-Seon
TI Plasma Clusterin (ApoJ) Levels Are Associated with Adiposity and
   Systemic Inflammation
SO PLOS ONE
LA English
DT Article
ID CORONARY-HEART-DISEASE; GENOME-WIDE ASSOCIATION; C-REACTIVE PROTEIN;
   APOLIPOPROTEIN-J; INSULIN-RESISTANCE; ALZHEIMERS-DISEASE;
   CLUSTERIN/APOLIPOPROTEIN-J; IDENTIFIES VARIANTS; METABOLIC SYNDROME;
   OXIDATIVE STRESS
AB Obesity and insulin resistance are hallmarks of the metabolic syndrome, which is associated with low-grade chronic inflammation. Clusterin/apolipoprotein J is an abundant plasma chaperone protein that has recently been suggested as a potential biomarker that reflects the inflammatory process in Alzheimer's disease. In the present study, we investigated anthropometric and clinical factors affecting the plasma levels of clusterin in healthy Korean subjects. We measured fasting plasma clusterin levels in healthy Korean adults (111 men and 93 women) using ELISA kit. We analyzed the relationship between plasma clusterin concentrations and anthropometric and clinical parameters. Fasting plasma clusterin concentrations were higher in overweight and obese subjects than in lean subjects. Correlation analysis revealed that the plasma clusterin levels were positively associated with indices of obesity such as body mass index (BMI), waist circumference and waist-hip ratio and markers of systemic inflammation such as high sensitivity C-reactive protein (hsCRP), uric acid, ferritin and retinol binding protein-4. Multiple linear regression analysis showed that sex, BMI and hsCRP were independent determinants of plasma clusterin levels. Furthermore, plasma clusterin levels showed an upward trend with increasing numbers of metabolic syndrome components. These findings suggest that fasting plasma clusterin levels correlate with the parameters of adiposity and systemic inflammation in healthy adults. Therefore, the circulating clusterin level may be a surrogate marker for obesity-associated systemic inflammation.
C1 [Won, Jong Chul] Inje Univ, Sanggye Paik Hosp, Coll Med, Dept Internal Med,Cardiovasc & Metab Dis Ctr, Seoul, South Korea.
   [Park, Cheol-Young] Sungkyunkwan Univ, Kangbuk Samsung Hosp, Sch Med, Dept Internal Med, Seoul, South Korea.
   [Oh, Sang Woo] Dongguk Univ, Ilsan Hosp, Dept Family Med, Ilsan, South Korea.
   [Lee, Eon Sook] Inje Univ, Ilsan Paik Hosp, Coll Med, Dept Family Med,Ctr Hlth Promot, Ilsan, South Korea.
   [Youn, Byung-Soo] Wonkang Univ, Sch Med, Dept Anat, Iksan, Jeonbuk, South Korea.
   [Kim, Min-Seon] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Internal Med, Seoul, South Korea.
C3 Inje University; Sungkyunkwan University (SKKU); Samsung Medical Center;
   NHIS Ilsan Hospital; Dongguk University; Inje University; Wonkwang
   University; University of Ulsan; Asan Medical Center
RP Youn, BS (corresponding author), Wonkang Univ, Sch Med, Dept Anat, Iksan, Jeonbuk, South Korea.
EM byung4jc@gmail.com; mskim@amc.seoul.kr
RI Park, Cheol-Young/C-6690-2018
OI Park, Cheol-Young/0000-0002-9415-9965; Lee, Eon
   Sook/0000-0002-6148-2512; Won, Jong Chul/0000-0002-2219-4083; Oh, Sang
   Woo/0000-0002-5623-6720
FU National Research Foundation of Korea [2013M3C7A1056024]; Asan Institute
   for Life Science [11similar to326]; Priority Research Centers Program
   through the National Research Foundation of Korea (NRF) - Ministry of
   Education, Science and Technology [2010-0020224]
FX This study was supported by grants from the National Research Foundation
   of Korea (2013M3C7A1056024), and the Asan Institute for Life Science (11
   similar to 326). This study was also supported by a Priority Research
   Centers Program through the National Research Foundation of Korea (NRF)
   funded by the Ministry of Education, Science and Technology
   (2010-0020224). The funders had no role in study design, data collection
   and analysis, decision to publish, or preparation of the manuscript.
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NR 37
TC 73
Z9 77
U1 0
U2 7
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JUL 30
PY 2014
VL 9
IS 7
AR e103351
DI 10.1371/journal.pone.0103351
PG 7
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA AM7EZ
UT WOS:000340028800040
PM 25076422
OA Green Submitted, gold, Green Published
DA 2025-06-11
ER

PT J
AU Leisegang, K
   Udodong, A
   Bouic, PJD
   Henkel, RR
AF Leisegang, K.
   Udodong, A.
   Bouic, P. J. D.
   Henkel, R. R.
TI Effect of the metabolic syndrome on male reproductive function: a
   case-controlled pilot study
SO ANDROLOGIA
LA English
DT Article
DE male infertility; metabolic syndrome; obesity; progesterone;
   testosterone
ID BODY-MASS INDEX; SEMEN QUALITY; SPERM FUNCTION; MALE OBESITY;
   MALE-INFERTILITY; TNF-ALPHA; MEN; TESTOSTERONE; HORMONES; IMPACT
AB The metabolic syndrome (MetS) is a constellation of various risk factors. This study aimed to investigate the effect of MetS on testosterone and progesterone, and semen parameters, in a case-controlled pilot study. Male patients (n=54) had body mass index, waist-to-hip ratio (WHR) and blood pressure recorded. Blood was analysed for HDL cholesterol, triglycerides and glucose. Saliva was assayed for free testosterone and free progesterone. Ejaculates were analysed for volume, sperm concentration, total sperm count, motility, vitality, mitochondrial membrane potential (MMP), DNA fragmentation and leucocyte concentration. Participants were divided into the control group (n=28) and the MetS group (n=26). Differences were found between the groups for body mass index, WHR, blood pressure, high-density lipoprotein (HDL), triglycerides and glucose. The MetS group showed significant reductions in sperm concentration (P=0.0026), total sperm count (P=0.0034), total motility (P=0.0291), sperm vitality (P=0.002), MMP (P=0.0039), free testosterone (P=0.0093) and free progesterone (P=0.0130), while values for DNA fragmentation increased (P=0.0287). Results indicate that patients with MetS have compromised sperm parameters in the absence of leucocytospermia. A reduction in free progesterone suggests that steroidogenesis cascades may be compromised. It is hypothesised that a systemic pro-inflammatory state with oxidative stress associated with MetS may provide a novel explanation.
C1 [Leisegang, K.; Udodong, A.; Henkel, R. R.] Univ Western Cape, Dept Med Biosci, ZA-7535 Bellville, South Africa.
   [Leisegang, K.] Univ Western Cape, Sch Nat Med, ZA-7535 Bellville, South Africa.
   [Bouic, P. J. D.] Univ Stellenbosch, Div Med Microbiol, Dept Pathol, ZA-7505 Tygerberg, South Africa.
   [Bouic, P. J. D.] Tygerberg Acad Hosp, Tygerberg, South Africa.
C3 University of the Western Cape; University of the Western Cape;
   Stellenbosch University
RP Henkel, RR (corresponding author), Univ Western Cape, Dept Med Biosci, Private Bag X17, ZA-7535 Bellville, South Africa.
EM rhenkel@uwc.ac.za
RI Leisegang, Kristian/AAS-3925-2021
OI Leisegang, Kristian/0000-0002-3003-8048; Henkel,
   Ralf/0000-0003-1128-2982
FU South African Medical Research Council, Parow, South Africa
FX The authors wish to thank the South African Medical Research Council,
   Parow, South Africa, for funding this study.
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NR 57
TC 49
Z9 50
U1 0
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0303-4569
EI 1439-0272
J9 ANDROLOGIA
JI Andrologia
PD MAR
PY 2014
VL 46
IS 2
BP 167
EP 176
DI 10.1111/and.12060
PG 10
WC Andrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA AA7KH
UT WOS:000331275800014
PM 23278477
OA gold
DA 2025-06-11
ER

PT J
AU Higuchi, Y
   Maeda, T
   Guan, JZ
   Oyama, J
   Sugano, M
   Makino, N
AF Higuchi, Yoshihiro
   Maeda, Toyoki
   Guan, Jing-Zhi
   Oyama, Junichi
   Sugano, Masahiro
   Makino, Naoki
TI Diagonal Earlobe Crease are Associated With Shorter Telomere in Male
   Japanese Patients With Metabolic Syndrome-A Pilot Study-
SO CIRCULATION JOURNAL
LA English
DT Article
DE Aging; Atherosclerosis; Earlobe crease; Metabolic syndrome; Telomere
   length
ID CORONARY-ARTERY-DISEASE; EAR-LOBE CREASE; OXIDATIVE STRESS; LENGTH;
   RISK; ATHEROSCLEROSIS; SIGN; STIFFNESS; BIOLOGY; MARKER
AB Background Diagonal earlobe crease (ELC) have been proposed as a marker of generalized atherosclerosis, so in the present study it was investigated whether individuals with ELC have a shortened telomere, which correlates with an accelerated cell turnover and premature aging, leading to atherosclerosis.
   Methods and Results The mean terminal restriction fragment (TRF) was determined by Southern blot hybridization in the peripheral blood cells of 34 male Japanese patients with metabolic syndrome (MetS) who were under 70 years of age with (n=17) and without (n=17) bilateral ELC, and assessed the relationship of ELC to atherosclerotic cardiovascular disease (AVD). The results showed that the TRF was shorter in the MetS patients with ELC in comparison to age- and risk-factor-matched MetS patients without ELC (7.6 +/- 1.1 kbp vs 8.6 +/- 1.2 kbp; P<0.05). ELC were present in 13 patients in the AVD group (n=18), but only 4 patients in the non-AVD group (n=16) had ELC (72.2% and 25% respectively; P<0.05).
   Conclusions These findings suggest that ELC is a useful dermatological indicator of an accelerated aging process, as suggested by excessive telomere loss, and might be a useful indirect marker of high-risk patients. (Circ J 2009; 73: 274-279)
C1 [Higuchi, Yoshihiro; Maeda, Toyoki; Guan, Jing-Zhi; Oyama, Junichi; Sugano, Masahiro; Makino, Naoki] Kyushu Univ, Med Inst Bioregulat, Dept Mol & Cellular Biol, Div Mol & Clin Gerontol, Beppu, Oita 8740838, Japan.
C3 Kyushu University
RP Higuchi, Y (corresponding author), Kyushu Univ, Med Inst Bioregulat, Dept Mol & Cellular Biol, Div Mol & Clin Gerontol, 4586 Tsurumihara, Beppu, Oita 8740838, Japan.
EM yhiguchi@beppu.kyushu-u.ac.jp
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NR 36
TC 47
Z9 49
U1 0
U2 2
PU JAPANESE CIRCULATION SOC
PI TOYKO
PA 18TH FLOOR IMPERIAL HOTEL TOWER, 1-1-1 UCHISAIWAI-CHO CHIYODA-KU, TOYKO,
   100-0011, JAPAN
SN 1346-9843
EI 1347-4820
J9 CIRC J
JI Circ. J.
PD FEB
PY 2009
VL 73
IS 2
BP 274
EP 279
DI 10.1253/circj.CJ-08-0267
PG 6
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 399TN
UT WOS:000262822300015
PM 19060421
OA Bronze
DA 2025-06-11
ER

PT J
AU Hollman, G
   Kristenson, M
AF Hollman, Gunilla
   Kristenson, Margareta
TI The prevalence of the metabolic syndrome and its risk factors in a
   middle-aged Swedish population - Mainly a function of overweight?
SO EUROPEAN JOURNAL OF CARDIOVASCULAR NURSING
LA English
DT Article
DE Metabolic syndrome; Prevalence; Population
ID LOW-DENSITY-LIPOPROTEIN; HEALTH; TRENDS; PREDICTION; DISEASE; OBESITY;
   STRESS; WOMEN; MEN
AB Background: The prevalence of obesity, one risk factor for developing the metabolic syndrome (MS), has increased during the last decades. It has therefore been assumed that the prevalence of MS would also increase.
   Aims: The aim was to analyse the prevalence of MS and its risk factors in a middle-aged Swedish population.
   Methods: Data were obtained between 2003 and 2004 from a random population based sample of 502 men and 505 women, 45-69 years old. Measures of plasma glucose, serum lipids, blood pressure, weight, height, waist circumference and self-reported data concerning presence of disease, medication and lifestyle were obtained.
   Results: The prevalence of MS was 14.8% among men and 15.3% among women, with an increase by age among women only, 10% to 25% (p=0.029). Among individuals with MS the most frequent risk factor was large waist circumference, present in 85% of men and 99% of women, followed by high blood pressure, high triglycerides, high glucose and HDL cholesterol (38% and 47% respectively).
   Conclusion: The prevalence of MS was 15%, increasing with age only among women. Overweight was a dominant characteristic, and only half of the individuals with MS had glucose/HDL cholesterol levels beyond defined cut points of the syndrome. (C) 2007 European Society of Cardiology. Published by Elsevier B.V. All rights reserved.
C1 [Hollman, Gunilla] Linkoping Univ, Fac Hlth Sci, Div Nursing Sci, Dept Med & Care, S-58185 Linkoping, Sweden.
   [Kristenson, Margareta] Linkoping Univ, Fac Hlth Sci, Div Prevent & Social Med, Dept Hlth & Soc, S-58185 Linkoping, Sweden.
C3 Linkoping University; Linkoping University
RP Hollman, G (corresponding author), Linkoping Univ, Fac Hlth Sci, Div Nursing Sci, Dept Med & Care, S-58185 Linkoping, Sweden.
EM gunho@imv.liu.se
FU Swedish Heart and Lung Foundation [2004-1881]; Swedish Research Council
   [20040530]; Faculty of Health and Sciences, Linkoping University
FX We thank professor, Anders G Olsson, for introducing us into this field
   and for constructive criticism. We also thank the LSH study group for
   supportive discussions.We also thank the Swedish Heart and Lung
   Foundation (2004-1881), the Swedish Research Council (20040530) and the
   Faculty of Health and Sciences, Linkoping University for financial
   support.
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NR 33
TC 43
Z9 50
U1 0
U2 3
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1474-5151
EI 1873-1953
J9 EUR J CARDIOVASC NUR
JI Eur. J. Cardiovasc. Nurs.
PD MAR
PY 2008
VL 7
IS 1
BP 21
EP 26
DI 10.1016/j.ejcnurse.2007.05.003
PG 6
WC Cardiac & Cardiovascular Systems; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Cardiovascular System & Cardiology; Nursing
GA 368NG
UT WOS:000260627300006
PM 17586094
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Thomas, MS
   DiBella, M
   Blesso, CN
   Malysheva, O
   Caudill, M
   Sholola, M
   Cooperstone, JL
   Fernandez, ML
AF Thomas, Minu S.
   DiBella, Marissa
   Blesso, Christopher N.
   Malysheva, Olga
   Caudill, Marie
   Sholola, Maria
   Cooperstone, Jessica L.
   Fernandez, Maria Luz
TI Comparison between Egg Intake versus Choline Supplementation on Gut
   Microbiota and Plasma Carotenoids in Subjects with Metabolic Syndrome
SO NUTRIENTS
LA English
DT Article
DE metabolic syndrome; gut microbiota; choline; TMAO; lutein; zeaxanthin
ID TRIMETHYLAMINE-N-OXIDE; OXIDATIVE STRESS; ANTIOXIDANT CONCENTRATIONS;
   ZEAXANTHIN CONCENTRATIONS; CARDIOVASCULAR-DISEASE; LOWER PREVALENCE;
   DIETARY CHOLINE; TMAO LEVELS; BETAINE; HOMOCYSTEINE
AB We previously demonstrated that intake of three eggs/d for 4 weeks increased plasma choline and decreased inflammation in subjects with metabolic syndrome (MetS). The purpose of the current study was to further explore the effects of phosphatidylcholine (PC) provided by eggs versus a choline bitartrate (CB) supplement on the gut microbiota, trimethylamine N-oxide (TMAO) formation, and plasma carotenoids lutein and zeaxanthin in MetS. This randomized, controlled crossover clinical trial included 23 subjects with MetS. Following a washout period of 2 weeks without consuming any choline-containing foods, subjects were randomly allocated to consume either three eggs/d or a CB supplement for 4 weeks (both diets had a choline equivalent of 400 mg/day). DNA was extracted from stool samples to sequence the 16S rRNA gene region for community analysis. Operational taxonomic units (OTUs) and the alpha-diversity of the community were determined using QIIME software. Plasma TMAO, methionine, betaine, and dimethylglycine (DMG) were quantified by stable isotope dilution liquid chromatography with tandem mass spectrometry. Plasma carotenoids, lutein, and zeaxanthin were measured using reversed-phase high-performance liquid chromatography. There were significant increases in plasma lutein and zeaxanthin after egg intake compared to the baseline or intake of CB supplement (p < 0.01). In contrast, TMAO was not different between treatments compared to the baseline (p > 0.05). Additionally, while diet intervention had no effects on microbiota diversity measures or relative taxa abundances, a correlation between bacterial biodiversity and HDL was observed. Following egg intake, the observed increases in plasma lutein and zeaxanthin may suggest additional protection against oxidative stress, a common condition in MetS.
C1 [Thomas, Minu S.; DiBella, Marissa; Blesso, Christopher N.; Fernandez, Maria Luz] Univ Connecticut, Dept Nutr Sci, Storrs, CT 06269 USA.
   [Malysheva, Olga; Caudill, Marie] Cornell Univ, Dept Human Nutr, Div Nutr Sciecnces, Ithaca, NY 14860 USA.
   [Sholola, Maria; Cooperstone, Jessica L.] Ohio State Univ, Dept Food Sci & Technol, Columbus, OH 43210 USA.
   [Cooperstone, Jessica L.] Ohio State Univ, Dept Hort & Crop Sci, Columbus, OH 43210 USA.
C3 University of Connecticut; Cornell University; University System of
   Ohio; Ohio State University; University System of Ohio; Ohio State
   University
RP Fernandez, ML (corresponding author), Univ Connecticut, Dept Nutr Sci, Storrs, CT 06269 USA.
EM minu.thomas@uconn.edu; marissa.dibella@uconn.edu;
   christopher.blesso@uconn.edu; ovm4@cornell.edu; mac279@cornell.edu;
   sholola.1@osu.edu; cooperstone.1@osu.edu; maria-luz.fernandez@uconn.edu
RI Blesso, Christopher/N-9495-2014; Thomas, Minu Sara/GOH-1463-2022
OI Fernandez, Maria-Luz/0000-0002-1835-0792; Caudill,
   Marie/0000-0002-7192-5743; Blesso, Christopher/0000-0002-4434-4839;
   Thomas, Minu Sara/0000-0002-1639-3086
FU Egg Nutrition Center
FX This study was funded by the Egg Nutrition Center.
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NR 84
TC 13
Z9 14
U1 0
U2 4
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD MAR
PY 2022
VL 14
IS 6
AR 1179
DI 10.3390/nu14061179
PG 15
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 0E1HK
UT WOS:000776434600001
PM 35334836
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Simao, TNC
   Lozovoy, MAB
   Simao, ANC
   Oliveira, SR
   Venturini, D
   Morimoto, HK
   Miglioranza, LHS
   Dichi, I
AF Colado Simao, Tathiana Name
   Batisti Lozovoy, Marcell Alysson
   Colado Simao, Andrea Name
   Oliveira, Sayonara Rangel
   Venturini, Danielle
   Morimoto, Helena Kaminami
   Silva Miglioranza, Lucia Helena
   Dichi, Isaias
TI Reduced-energy cranberry juice increases folic acid and adiponectin and
   reduces homocysteine and oxidative stress in patients with the metabolic
   syndrome
SO BRITISH JOURNAL OF NUTRITION
LA English
DT Article
DE Metabolic syndrome; Cranberry juice; Folic acid; Adiponectin;
   Homocysteine
ID PLASMA ANTIOXIDANT CAPACITY; ADIPOSE-SPECIFIC PROTEIN;
   CORONARY-HEART-DISEASE; C-REACTIVE PROTEIN; CARDIOVASCULAR-DISEASE;
   INSULIN-RESISTANCE; GRAPE JUICE; VITAMIN INTERVENTION; ISCHEMIC-STROKE;
   RISK-FACTORS
AB The metabolic syndrome (MetS) comprises pathological conditions that include insulin resistance, arterial hypertension, visceral adiposity and dyslipidaemia, which favour the development of CVD. Some reports have shown that cranberry ingestion reduces cardiovascular risk factors. However, few studies have evaluated the effect of this fruit in subjects with the MetS. The objective of the present study was to assess the effect of reduced-energy cranberry juice consumption on metabolic and inflammatory biomarkers in patients with the MetS, and to verify the effects of cranberry juice concomitantly on homocysteine and adiponectin levels in patients with the MetS. For this purpose, fifty-six individuals with the MetS were selected and divided into two groups: control group (n 36) and cranberry-treated group (n 20). After consuming reduced-energy cranberry juice (0.7 litres/d) containing 0.4mg folic acid for 60 d, the cranberry-treated group showed an increase in adiponectin (P=0.010) and folic acid (P=0.033) and a decrease in homocysteine (P<0.001) in relation to baseline values and also in comparison with the controls (P<0.05). There was no significant change in the pro-inflammatory cytokines TNF-alpha, IL-1 and IL-6. In relation to oxidative stress measurements, decreased (P<0.05) lipoperoxidation and protein oxidation levels assessed by advanced oxidation protein products were found in the cranberry-treated group when compared with the control group. In conclusion, the consumption of cranberry juice for 60 d was able to improve some cardiovascular risk factors. The present data reinforce the importance of the inverse association between homocysteine and adiponectin and the need for more specifically designed studies on MetS patients.
C1 [Colado Simao, Tathiana Name] Philadelphia Univ Ctr UNIFIL Londrina, Dept Nutr, Londrina, Parana, Brazil.
   [Batisti Lozovoy, Marcell Alysson] Univ North Parana UNOPAR, Dept Clin Anal, Londrina, Parana, Brazil.
   [Colado Simao, Andrea Name; Oliveira, Sayonara Rangel; Venturini, Danielle; Morimoto, Helena Kaminami] Univ Londrina, Dept Pathol Clin Anal & Toxicol, BR-86038440 Londrina, Parana, Brazil.
   [Silva Miglioranza, Lucia Helena] Univ Londrina, Dept Food Sci & Technol, BR-86038440 Londrina, Parana, Brazil.
   [Dichi, Isaias] Univ Londrina, Dept Internal Med, BR-86038440 Londrina, Parana, Brazil.
C3 University Norte Parana
RP Dichi, I (corresponding author), Univ Londrina, Dept Internal Med, Robert Koch Ave 60, BR-86038440 Londrina, Parana, Brazil.
EM dichi@sercomtel.com.br
RI Simão, Andrea/AAM-4892-2021; Venturini, Danielle/HPH-1330-2023;
   Miglioranza, Lucia/H-1656-2012; Lozovoy, Marcell/AAM-4897-2021
FU National Council of Brazilian Research - CNPq
FX The present study was supported by the National Council of Brazilian
   Research - CNPq. Juxx Company supplied the cranberry juice. The authors'
   contributions are as follows: T. N. C. S., A. N. C. S. and I. D.
   designed the research; T. N. C. S., A. N. C. S., M. A. B. L., D. V., L.
   H. S. M. and H. K. M. conducted the research; T. N. C. S., A. N. C. S.
   and I. D. analysed the data; T. N. C. S., A. N. C. S. and I. D. wrote
   the paper; I. D. had primary responsibility for the final content. All
   authors read and approved the final manuscript. None of the authors had
   any conflict of interest in relation to the present study.
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NR 83
TC 52
Z9 54
U1 0
U2 22
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1145
EI 1475-2662
J9 BRIT J NUTR
JI Br. J. Nutr.
PD NOV 28
PY 2013
VL 110
IS 10
BP 1885
EP 1894
DI 10.1017/S0007114513001207
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 250VF
UT WOS:000326883600016
PM 23750500
OA Bronze
DA 2025-06-11
ER

PT J
AU Zhao, XJ
   Chen, L
   Zhao, Y
   Pan, Y
   Yang, YZ
   Sun, Y
   Jiao, RQ
   Kong, LD
AF Zhao, Xiao-Juan
   Chen, Li
   Zhao, Yue
   Pan, Ying
   Yang, Yan-Zi
   Sun, Yang
   Jiao, Rui-Qing
   Kong, Ling-Dong
TI Polygonum cuspidatum extract attenuates fructose-induced liver
   lipid accumulation through inhibiting Keap1 and activating Nrf2
   antioxidant pathway
SO PHYTOMEDICINE
LA English
DT Article
DE Polygonum cuspidatum extract; Fructose; Liver lipid accumulation;
   Keap1/Nrf2 pathway
ID INDUCED HEPATIC STEATOSIS; NLRP3 INFLAMMASOME; OXIDATIVE STRESS;
   METABOLIC SYNDROME; ACID; MICE; EXPRESSION; INJURY
AB Background: Polygonum cuspidatum has been used in traditional Chinese medicine to treat liver disorders associated with oxidative stress, inflammation and lipid accumulation for centuries in patients.
   Purpose: The aim of this study was to examine whether P. cuspidatum extract (PCE) prevented against fructose-induced liver lipid accumulation via regulating Kelch-like ECH-associated protein 1 (Keap1)/nuclear factor erythroid 2-related factor 2 (Nrf2) pathway.
   Method: PCE was administered orally to male Sprague-Dawley rats given 10% fructose drinking water for 6 weeks at 80 and 160 mg/kg once daily for 11 weeks.
   Results: PCE significantly alleviated liver lipid accumulation in fructose-fed rats with metabolic syndrome. It also inhibited Keap1, activated Nrf2 antioxidant pathway, resulting in the suppression of oxidative stress, evidenced by reducing hydrogen peroxide (H2O2), malondialdehyde (MDA) and hydroxy radical (OH center dot) levels, and increasing glutathione (GSH)/oxidized glutathione (GSSG) ratio as well as superoxidase dismutase (SOD) and catalase (CAT) activity in the liver of fructose-fed rats. Additionally, PCE up-regulated peroxisome proliferator activated receptor-alpha (PPAR-alpha), and down-regulated sterol regulatory element binging protein 1 (SREBP-1), fatty acid synthetase (FAS) and stearoyl-CoA desaturase-1 (SCD-1) in this animal model, being consistent with its reduction of triglyceride (TG) levels.
   Conclusion: These results demonstrate that PCE reduces oxidative stress, and prevent lipid accumulation in the liver of fructose-fed rats possibly by targeting the Keap1/Nrf2 pathway. PCE may be a promising therapeutic strategy for fructose-associated liver lipid accumulation.
C1 [Zhao, Xiao-Juan; Chen, Li; Zhao, Yue; Pan, Ying; Yang, Yan-Zi; Sun, Yang; Jiao, Rui-Qing; Kong, Ling-Dong] Nanjing Univ, Sch Life Sci, State Key Lab Pharmaceut Biotechnol, Nanjing 210023, Jiangsu, Peoples R China.
C3 Nanjing University
RP Kong, LD (corresponding author), Nanjing Univ, Sch Life Sci, State Key Lab Pharmaceut Biotechnol, Nanjing 210023, Jiangsu, Peoples R China.
EM kongld@nju.edu.cn
FU National Natural Science Foundation of China [81573667, 81730105]
FX This work was supported by Grant from National Natural Science
   Foundation of China (Nos. 81573667 and 81730105) to Ling-Dong Kong.
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NR 40
TC 26
Z9 28
U1 6
U2 39
PU ELSEVIER GMBH
PI MUNICH
PA HACKERBRUCKE 6, 80335 MUNICH, GERMANY
SN 0944-7113
EI 1618-095X
J9 PHYTOMEDICINE
JI Phytomedicine
PD OCT
PY 2019
VL 63
AR 152986
DI 10.1016/j.phymed.2019.152986
PG 9
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA JR5YD
UT WOS:000499699300005
PM 31310912
DA 2025-06-11
ER

PT J
AU Feng, SD
   Zeng, YK
   Song, FM
   Shen, MX
   Yang, F
AF Feng, Shuidong
   Zeng, Yuke
   Song, Fengmei
   Shen, Minxue
   Yang, Fei
TI Microcystins Exposure and the Risk of Metabolic Syndrome: A
   Cross-Sectional Study in Central China
SO TOXINS
LA English
DT Article
DE microcystins; metabolic syndrome; mediation; cross-sectional study
ID OXIDATIVE STRESS; UNITED-STATES; RAT-LIVER; MC-LR; DISEASE;
   INFLAMMATION; OBESITY; TRENDS; COUNT
AB A growing body of evidence indicates that microcystins (MCs) exposure may cause metabolic diseases. However, studies exploring the effects of MCs exposure on the risk of metabolic syndrome (MetS) in humans are currently lacking, and the underlying mechanisms remain unclear. Here, we conducted a cross-sectional study in central China to explore the effect of serum MCs on MetS, and assessed the mediation effects of the inflammation biomarker, white blood cell (WBC) level, in this relationship. The relationships among MCs and WBC level and risk of MetS were assessed using binary logistic and linear regression. Mediation analysis was used to explore possible mechanisms underlying those associations by employing R software (version 4.3.1). Compared to the lowest quartile of MCs, the highest quartile had an increased risk of MetS (odds ratio [OR] = 2.10, 95% confidence interval [CI]: 1.19, 3.70), with a dose-response relationship (p for trend < 0.05). WBCs mediated 11.14% of the association between serum MCs and triglyceride (TG) levels, but did not mediate the association of MCs exposure with MetS. This study firstly reveals that MCs exposure is an independent risk factor for MetS in a dose-response manner, and suggests that WBC level could partially mediate the association of MCs exposure with TG levels.
C1 [Feng, Shuidong; Zeng, Yuke; Song, Fengmei; Yang, Fei] Univ South China, Sch Publ Hlth, Hengyang Med Sch, Dept Epidemiol & Hlth Stat,Key Lab Typ Environm Po, Hengyang 421001, Peoples R China.
   [Shen, Minxue] Cent South Univ, Xiangya Sch Publ Hlth, Dept Social Med & Hlth Management, Hunan Prov Key Lab Clin Epidemiol, Changsha 410000, Peoples R China.
C3 University of South China; Central South University
RP Yang, F (corresponding author), Univ South China, Sch Publ Hlth, Hengyang Med Sch, Dept Epidemiol & Hlth Stat,Key Lab Typ Environm Po, Hengyang 421001, Peoples R China.; Shen, MX (corresponding author), Cent South Univ, Xiangya Sch Publ Hlth, Dept Social Med & Hlth Management, Hunan Prov Key Lab Clin Epidemiol, Changsha 410000, Peoples R China.
EM shuidong_f@hotmail.com; yukezeng09@gmail.com; songfengmei2020@163.com;
   shenmx1988@csu.edu.cn; yangfeilong@126.com
RI Yang, Fei/H-7058-2019; Shen, Minxue/P-5140-2019
OI Yang, Fei/0000-0001-5687-0556; Shen, Minxue/0000-0003-0441-9303
FU Key Research and Development Projects in Hunan Province;  [2022SK2089]
FX This research was funded by the Key Research and Development Projects in
   Hunan Province (2022SK2089).
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NR 61
TC 1
Z9 1
U1 2
U2 2
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6651
J9 TOXINS
JI Toxins
PD DEC
PY 2024
VL 16
IS 12
AR 542
DI 10.3390/toxins16120542
PG 12
WC Food Science & Technology; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Toxicology
GA Q5X2B
UT WOS:001385396900001
PM 39728800
OA gold
DA 2025-06-11
ER

PT J
AU Johari, SM
   Shahar, S
AF Johari, Sa'ida Munira
   Shahar, Suzana
TI Metabolic syndrome: The association of obesity and unhealthy lifestyle
   among Malaysian elderly people
SO ARCHIVES OF GERONTOLOGY AND GERIATRICS
LA English
DT Article
DE Metabolic syndrome; Risk factors; Elderly; Malaysia
ID TIME PHYSICAL-ACTIVITY; C-REACTIVE PROTEIN; CARDIOVASCULAR-DISEASE;
   PREVALENCE; MORTALITY; RISK; POPULATION; ATHEROSCLEROSIS; QUESTIONNAIRE;
   INFLAMMATION
AB The aim of this study is to investigate the prevalence of metabolic syndrome (MetS) and its predictors among Malaysian elderly. A total of 343 elderly aged >= 60 years residing low cost flats in an urban area in the central of Malaysia were invited to participate in health screening in community centers. Subjects were interviewed to obtain socio demography, health status and behavior data. Anthropometric measurements were also measured. A total of 30 ml fasting blood was taken to determine fasting serum lipid, glucose level and oxidative stress. MetS was classified according to The International Diabetes Federation (IDF) criteria. The prevalence of MetS was 43.4%. More women (48.1%) were affected than men (36.3%) (p < 0.05). Being obese or overweight was the strongest predictor for MetS in men and women (p < 0.05, both gender). High carbohydrate intake increased risk of MetS in men by 2.8 folds. In women, higher fat free mass index, physical inactivity and good appetite increased risk of MetS by 3.9, 2.1 and 2.3 folds respectively. MetS affected almost half of Malaysian elderly being investigated, especially women, and is associated with obesity and unhealthy lifestyle. It is essential to develop preventive and intervention strategies to curb undesirable consequences associated with MetS. (C) 2014 Published by Elsevier Ireland Ltd.
C1 [Johari, Sa'ida Munira; Shahar, Suzana] Univ Kebangsaan Malaysia, Fac Hlth Sci, Sch Healthcare Sci, Kuala Lumpur 50300, Malaysia.
C3 Universiti Kebangsaan Malaysia
RP Shahar, S (corresponding author), Univ Kebangsaan Malaysia, Fac Hlth Sci, Sch Healthcare Sci, Kuala Lumpur 50300, Malaysia.
EM suzana.shahar@gmail.com
FU Universiti Kebangsaan Malaysia [UKM-GUP-SK-07-21-041]; Ministry of
   Science, Technology and Innovation [06-01-02-SF0551]
FX This project was partly funded by research grants from Universiti
   Kebangsaan Malaysia (UKM-GUP-SK-07-21-041) and Ministry of Science,
   Technology and Innovation (06-01-02-SF0551). The authors would like to
   acknowledge the contribution of the co-researchers and fieldworkers
   involved in this study. Many thanks are extended to the participants and
   staff at the community centers.
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NR 56
TC 17
Z9 17
U1 1
U2 23
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0167-4943
EI 1872-6976
J9 ARCH GERONTOL GERIAT
JI Arch. Gerontol. Geriatr.
PD SEP-OCT
PY 2014
VL 59
IS 2
BP 360
EP 366
DI 10.1016/j.archger.2014.04.003
PG 7
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA AO0RE
UT WOS:000341018300023
PM 24882592
DA 2025-06-11
ER

PT J
AU Mortimer, KRH
   Katshu, MZU
   Chakrabarti, L
AF Mortimer, Katherine R. H.
   Katshu, Mohammed Zia Ul Haq
   Chakrabarti, Lisa
TI Second-generation antipsychotics and metabolic syndrome: a role for
   mitochondria
SO FRONTIERS IN PSYCHIATRY
LA English
DT Review
DE antipsychotics; psychosis; mitochondria; energy metabolism; metabolic
   syndrome
ID ENERGY-METABOLISM; OXIDATIVE STRESS; OLANZAPINE; SCHIZOPHRENIA;
   CLOZAPINE; DRUGS; AMPK; AGRANULOCYTOSIS; DYSREGULATION; ASSOCIATION
AB Psychosis is a known risk factor for developing metabolic syndrome (MetS). The risk is even greater in patients who are taking second-generation antipsychotics (SGAs). SGAs exacerbate metabolic abnormalities and lead to a 3-fold increased risk of severe weight gain, type 2 diabetes, and cardiovascular disease in patients. Mitochondrial dysfunction is a hallmark of MetS. Mitochondria process glucose and fatty acids into ATP. If these processes are impaired, it can result in dyslipidaemia, hyperglycaemia and an imbalance between nutrient input and energy output. This leads to increased adiposity, insulin resistance and atherosclerosis. It is unclear how SGAs induce MetS and how mitochondria might be involved in this process. It has been found that SGAs impair cellular glucose uptake in liver, dysregulating glucose and fatty acid metabolism which leads to an accumulation of glucose and/or lipids and an increase reactive oxygen species (ROS) which target mitochondrial proteins. This affects complexes of the electron transport chain (ETC) to reduce mitochondrial respiration. While there is a suggestion that SGAs may interact with a variety of processes that disrupt mitochondrial function, some of the results are conflicting, and a clear picture of how SGAs interact with mitochondria in different cell types has not yet emerged. Here, we outline the current evidence showing how SGAs may trigger mitochondrial dysfunction and lead to the development of MetS.
C1 [Mortimer, Katherine R. H.; Chakrabarti, Lisa] Univ Nottingham, Sch Vet Med & Sci, Nottingham, England.
   [Katshu, Mohammed Zia Ul Haq] Univ Nottingham, Sch Med, Inst Mental Hlth, Nottingham, England.
   [Katshu, Mohammed Zia Ul Haq] Nottinghamshire Healthcare NHS Fdn Trust, Nottingham, England.
C3 University of Nottingham; University of Nottingham
RP Chakrabarti, L (corresponding author), Univ Nottingham, Sch Vet Med & Sci, Nottingham, England.
EM Lisa.Chakrabarti@nottingham.ac.uk
RI Chakrabarti, Lisa/G-4236-2011
OI Katshu, Mohammad Zia Ul Haq/0000-0002-1301-3359; Mortimer,
   Katherine/0000-0001-8788-2306
FU Biotechnology and Biological Sciences Research Council [BB/J014508/1]
FX The author(s) declare financial support was received for the research,
   authorship, and/or publication of this article. KM is funded by the
   Biotechnology and Biological Sciences Research Council (grant number
   BB/J014508/1).
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NR 67
TC 7
Z9 7
U1 1
U2 9
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-0640
J9 FRONT PSYCHIATRY
JI Front. Psychiatry
PD NOV 24
PY 2023
VL 14
AR 1257460
DI 10.3389/fpsyt.2023.1257460
PG 7
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA AA3D0
UT WOS:001115682000001
PM 38076704
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Ahn, BI
   Kim, MJ
   Koo, HS
   Seo, N
   Joo, NS
   Kim, YS
AF Ahn, Bang-In
   Kim, Moon Jong
   Koo, Hyung Suk
   Seo, Namkyung
   Joo, Nam-Seok
   Kim, Young-Sang
TI Serum Zinc Concentration Is Inversely Associated with Insulin Resistance
   but Not Related with Metabolic Syndrome in Nondiabetic Korean Adults
SO BIOLOGICAL TRACE ELEMENT RESEARCH
LA English
DT Article
DE Zinc; Serum zinc concentration; Insulin resistance; Metabolic syndrome;
   Korean
ID DENSITY-LIPOPROTEIN-CHOLESTEROL; OXIDATIVE STRESS; SUPPLEMENTATION;
   RISK; COMPONENTS
AB Although zinc was known to be associated with insulin metabolism and diabetes, the relationship of serum zinc concentration with insulin resistance (IR) and metabolic syndrome (MetS) was not well investigated in general population. The aim of this study is to evaluate the relationships of serum zinc concentration with IR and MetS in a nondiabetic adult population. This cross-sectional study included 656 men and 825 women who were nondiabetic adults from the fifth Korea National Health and Nutrition Examination Survey conducted in 2010. Serum zinc concentration and metabolic parameters were measured. IR was estimated by homeostatic model assessment (HOMA2). MetS was defined according to the National Cholesterol Education Program Adult Treatment Panel III criteria. Serum zinc concentration was negatively correlated with homeostasis model assessment for insulin resistance (HOMA2-IR) in men (r = -0.104, P = 0.008), but not in women. After adjusting for conventional cardiovascular risk factors, the inverse correlation was significant in both men and women (B = -0.262, SE = 0.060 for men, and B = -0.129, SE = 0.052 for women). However, serum zinc concentration was not different between the groups with and without MetS (P = 0.752 for men and P = 0.371 for women). In conclusion, serum zinc concentration was inversely associated with IR but not related to MetS in nondiabetic adult population.
C1 [Ahn, Bang-In; Kim, Moon Jong; Koo, Hyung Suk; Seo, Namkyung; Kim, Young-Sang] CHA Med Univ, Dept Family Med, CHA Bundang Med Ctr, Songnam 463712, Gyeonggi Do, South Korea.
   [Joo, Nam-Seok] Ajou Univ, Sch Med, Dept Family Med, Gyeonggi Do, South Korea.
C3 Ajou University
RP Kim, YS (corresponding author), CHA Med Univ, Dept Family Med, CHA Bundang Med Ctr, 59 Yatap Ro, Songnam 463712, Gyeonggi Do, South Korea.
EM zeroup@cha.ac.kr
RI Kim, Mark/HZH-8733-2023
OI Kim, Young-Sang/0000-0002-7397-5410
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NR 37
TC 42
Z9 45
U1 0
U2 3
PU HUMANA PRESS INC
PI TOTOWA
PA 999 RIVERVIEW DRIVE SUITE 208, TOTOWA, NJ 07512 USA
SN 0163-4984
EI 1559-0720
J9 BIOL TRACE ELEM RES
JI Biol. Trace Elem. Res.
PD AUG
PY 2014
VL 160
IS 2
BP 169
EP 175
DI 10.1007/s12011-014-0045-1
PG 7
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA AL7VC
UT WOS:000339343300003
PM 24943234
DA 2025-06-11
ER

PT J
AU Yuyama, K
   Mitsutake, S
   Igarashi, Y
AF Yuyama, Kohei
   Mitsutake, Susumu
   Igarashi, Yasuyuki
TI Pathological roles of ceramide and its metabolites in metabolic syndrome
   and Alzheimer's disease
SO BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
LA English
DT Review
DE Sphingolipid; Glycosphingolipid; Ceramide; Sphingomyelin; Metabolic
   syndrome; Alzheimer's disease
ID AMYLOID-BETA-PEPTIDE; INDUCED INSULIN-RESISTANCE; MILD COGNITIVE
   IMPAIRMENT; PRECURSOR PROTEIN; SPHINGOLIPID METABOLISM; GAMMA-SECRETASE;
   OXIDATIVE STRESS; LIPID MICRODOMAINS; IN-VIVO; CHOLESTEROL
AB The public health burden of metabolic syndrome (MetS), a multiplex risk factor that arises from insulin resistance accompanying abnormal adipose conditions, and Alzheimer's disease (AD), the most common form of dementia, continues to expand. Current available therapies for these disorders are of limited effectiveness. Recent findings have indicated that alternations in sphingolipid metabolism contribute to the development of these pathologies. Sphingolipids are major constituents of the plasma membrane, where they are known to form several types of microdomains, and are potent regulators for a variety of physiological processes. Many groups, including ours, have demonstrated that membrane sphingolipids, especially ceramide and its metabolites such as ceramide 1-phosphate, have roles in arteriosclerosis, obesity, diabetes, and inflammation associated with MetS. Aberrant sphingolipid profiles have been observed in human AD brains, and accumulated evidence has demonstrated that changes in membrane properties induced by defective sphingolipid metabolism impair generation and degradation of amyloid-beta peptide (A beta), a pathogenic agent of AD. In this review, we summarize current knowledge and pathophysiological implications of the roles of SLs in MetS and AD, to provide insight into the SL metabolic pathways as potential targets for therapy of these diseases. This article is part of a Special Issue entitled New Frontiers in Sphingolipid Biology. (C) 2013 Elsevier B.V. All rights reserved.
C1 [Yuyama, Kohei; Mitsutake, Susumu; Igarashi, Yasuyuki] Hokkaido Univ, Grad Sch Adv Life Sci, Frontier Res Ctr Postgenome Sci & Technol, Lab Biomembrane & Biofunct Chem, Sapporo, Hokkaido 0010021, Japan.
C3 Hokkaido University
RP Mitsutake, S (corresponding author), Hokkaido Univ, Fac Adv Life Sci, Kita Ku, Kita 21,Nishi 11, Sapporo, Hokkaido 0010021, Japan.
EM susumu-m@pharm.hokudai.ac.jp
RI Mitsutake, Susumu/A-4082-2012
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NR 82
TC 58
Z9 66
U1 1
U2 45
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1388-1981
EI 0006-3002
J9 BBA-MOL CELL BIOL L
JI Biochim. Biophys. Acta Mol. Cell Biol. Lipids
PD MAY
PY 2014
VL 1841
IS 5
SI SI
BP 793
EP 798
DI 10.1016/j.bbalip.2013.08.002
PG 6
WC Biochemistry & Molecular Biology; Biophysics; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Cell Biology
GA AG8ZC
UT WOS:000335706400017
PM 23948264
DA 2025-06-11
ER

PT J
AU Boullu-Ciocca, S
   Dutour, A
   Guillaume, V
   Achard, V
   Oliver, C
   Grino, M
AF Boullu-Ciocca, S
   Dutour, A
   Guillaume, V
   Achard, V
   Oliver, C
   Grino, M
TI Postnatal diet-induced obesity in rats upregulates systemic and adipose
   tissue glucocorticoid metabolism during development and in adulthood -
   Its relationship with the metabolic syndrome
SO DIABETES
LA English
DT Article
ID 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1; PARAVENTRICULAR
   HYPOTHALAMIC NUCLEUS; BRAIN CORTICOSTEROID RECEPTORS;
   PITUITARY-ADRENAL-FUNCTION; OVERFED WEANLING RATS; IN-SITU
   HYBRIDIZATION; MESSENGER-RNA; SELECTIVE-INHIBITION; HYPERGLYCEMIC MICE;
   INSULIN-RESISTANCE
AB In humans, a hyperactivity of glucocorticoid metabolism was postulated to be involved in the intrauterine programming of the metabolic syndrome in adulthood. We studied in rats the effects of overfeeding, obtained by reducing the size of the litter in the immediate postnatal period, a time crucial for neuroendocrine maturation such as late gestation in humans. Overfeeding induced early-onset obesity and accelerated the maturation of the hypothalamo-pituitary-adrenal (HPA) axis together with an upregulation of adipose tissue glucocorticoid receptor (GR) mRNA. In adulthood, neonatally overfed rats presented with moderate increases in basal and stress-induced corticosterone secretion and striking changes in visceral adipose tissue glucocorticoid signaling, that is, enhanced GR and 11beta-hydroxysteroid dehydrogenate type 1 mRNA levels. The above-mentioned alterations in the endocrine status of overfed rats were accompanied by a moderate overweight status and significant metabolic disturbances comparable to those described in the metabolic syndrome. Our data demonstrate for the first time that postnatal overfeeding accelerates the maturation of the HPA axis and leads to permanent upregulation of the HPA axis and increased adipose tissue glucocorticoid sensitivity. Thus, the experimental paradigm of postnatal overfeeding is a powerful tool to understand the pathophysiology of glucocorticoid-induced programming of metabolic axes.
C1 Univ Mediterranee, Fac Med, INSERM, UMR 626,Hematol Lab, F-13385 Marseille 5, France.
   N Hosp, Endocrinol & Nutr Unit, Marseille, France.
C3 Institut National de la Sante et de la Recherche Medicale (Inserm);
   Aix-Marseille Universite; Aix-Marseille Universite; Assistance
   Publique-Hopitaux de Marseille
RP Univ Mediterranee, Fac Med, INSERM, UMR 626,Hematol Lab, 27 Bd Jean Moulin, F-13385 Marseille 5, France.
EM michel.grino@medecine.univ-mrs.fr
RI Grino, Michel/O-5361-2017; Dutour, Anne/AAK-4460-2020
OI Dutour, Anne/0000-0002-5844-5884
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NR 46
TC 157
Z9 173
U1 0
U2 9
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0012-1797
EI 1939-327X
J9 DIABETES
JI Diabetes
PD JAN
PY 2005
VL 54
IS 1
BP 197
EP 203
DI 10.2337/diabetes.54.1.197
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 886SA
UT WOS:000226247500026
PM 15616029
OA Bronze
DA 2025-06-11
ER

PT J
AU Chen, LR
   Chen, Y
   Wang, B
   Yang, ZC
   Cai, ZY
   Wang, XK
   Sun, LD
   Li, Z
   Wang, GJ
AF Chen, Lianru
   Chen, Ya
   Wang, Bin
   Yang, Zhongcheng
   Cai, Zongyu
   Wang, Xuekun
   Sun, Lidan
   Li, Zheng
   Wang, Guangji
TI Design, synthesis, and biological evaluation of deuterated
   indolepropionic acid derivatives as novel long-acting pan PPARα/γ/δ
   agonists
SO BIOORGANIC & MEDICINAL CHEMISTRY
LA English
DT Article
DE Deuteration; Metabolic syndrome; PPAR pan-agonist; Hyperlipidemia; NASH
ID LIVER; GAMMA; PATHOGENESIS; ACTIVATION; DISCOVERY; LIGANDS; MODELS;
   POTENT; ALPHA
AB Metabolic syndrome is a complex disease with diverse symptoms, but current pharmacological interventions have limited efficacy. Indeglitazar, a pan-agonist targeting the three-peroxisome proliferator activated receptors (PPAR), exhibits significant therapeutic effects on both diabetic and fatty liver animal models. However, its short half-life limits the in vivo efficacy, which might be attributed to the beta-oxidation of indolepropionic acid at Indeglitazar. To overcome this metabolic instability, two deuterium atoms were introduced to the alpha-position of indolepropionic acid to block the beta-oxidation. In this study, several deuterated derivatives were found to sustain PPARs activity and extend the half-life of liver microsomes. In oral glucose tolerance tests, I-1 exhibited the strongest glucose-lowering effect on ob/ob mice in this series. In db/db mice, I-1 reduced lipid levels, liver steatosis and promoted UCP1 expression in white adipose tissue. Mechanistic studies further revealed that I-1 exerts stronger effects than Indeglitazar on the regulation of genes related to lipid metabolism, mitochondrial function, and oxidative stress. Furthermore, I-1 significantly reduced liver steatosis, hepatocellular ballooning, inflammation, and fibrosis in NASH model induced by HFD + CCl4, and even exerted better therapeutic effect than that of Indeglitazar. With the above attractive efficacy, deuterated derivative I-1 is considered as a promising treatment for metabolic syndrome.
C1 [Chen, Lianru; Chen, Ya; Wang, Bin; Yang, Zhongcheng; Cai, Zongyu; Li, Zheng; Wang, Guangji] Guangdong Pharmaceut Univ, Sch Pharm, Guangzhou 510006, Peoples R China.
   [Sun, Lidan] Jiaxing Univ, Coll Med, Dept Pharmaceut, Jiaxing Key Lab Photonanomedicine & Expt Therapeut, Jiaxing, Zhejiang, Peoples R China.
   [Chen, Lianru; Yang, Zhongcheng; Li, Zheng] Guangdong Pharmaceut Univ, Key Specialty Clin Pharm, Affiliated Hosp 1, Guangzhou 510006, Peoples R China.
   [Chen, Ya; Wang, Bin] Guangdong Pharmaceut Univ, Ctr Drug Res & Dev, Guangzhou 510006, Peoples R China.
   [Chen, Ya; Wang, Bin; Li, Zheng] Guangdong Pharmaceut Univ, Guangdong Prov Educ Dept, Key Lab New Drug Discovery & Evaluat, Guangzhou 510006, Peoples R China.
   [Cai, Zongyu; Li, Zheng] Guangdong Pharmaceut Univ, Guangzhou Key Lab Construct & Applicat New Drug Sc, Guangzhou 510006, Peoples R China.
   [Wang, Xuekun] Liaocheng Univ, Sch Pharmaceut Sci, Liaocheng 252059, Shandong, Peoples R China.
   [Li, Zheng] Guangdong Prov Key Lab New Drug Design & Evaluat, Guangzhou 510006, Peoples R China.
C3 Guangdong Pharmaceutical University; Jiaxing University; Guangdong
   Pharmaceutical University; Guangdong Pharmaceutical University;
   Guangdong Pharmaceutical University; Guangdong Pharmaceutical
   University; Liaocheng University
RP Li, Z; Wang, GJ (corresponding author), Guangdong Pharmaceut Univ, Sch Pharm, Guangzhou 510006, Peoples R China.; Sun, LD (corresponding author), Jiaxing Univ, Coll Med, Dept Pharmaceut, Jiaxing Key Lab Photonanomedicine & Expt Therapeut, Jiaxing, Zhejiang, Peoples R China.
EM slidan89@mail.zjxu.edu.cn; lizhengdrug@gdpu.edu.cn; gjwang@cpu.edu.cn
RI Zhang, Yi/KHW-2039-2024; bin, wang/X-9166-2019
FU Basic and Applied Basic Research of Guangzhou [202201010436]; National
   Key Clinical Specialty Construction Project (Clinical Pharmacy);
   Guangdong Provincial Key Laboratory of Construction Foundation
   [2020B1212060034]; Beijing Key Laboratory of Metabolic Disorder Related
   Cardiovascular Disease [DXWL-202304]; High-Level Clinical Key Specialty
   (Clinical Pharmacy) in Guangdong Province
FX This study was supported by Basic and Applied Basic Research of
   Guangzhou (202201010436) , National Key Clinical Specialty Construction
   Project (Clinical Pharmacy) , and High-Level Clinical Key Specialty
   (Clinical Pharmacy) in Guangdong Province, Guangdong Provincial Key
   Laboratory of Construction Foundation (2020B1212060034) , Beijing Key
   Laboratory of Metabolic Disorder Related Cardiovascular Disease
   (DXWL-202304) .
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NR 43
TC 0
Z9 0
U1 3
U2 10
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0968-0896
EI 1464-3391
J9 BIOORGAN MED CHEM
JI Bioorg. Med. Chem.
PD DEC 15
PY 2023
VL 96
AR 117533
DI 10.1016/j.bmc.2023.117533
EA NOV 2023
PG 12
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Chemistry,
   Organic
WE Science Citation Index Expanded (SCI-EXPANDED); Index Chemicus (IC)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Chemistry
GA Z7FL8
UT WOS:001113693800001
PM 37976807
DA 2025-06-11
ER

PT J
AU Souza, APD
   Barros, WMA
   Silva, JML
   Silva, MRM
   Silva, ABJ
   Fernandes, MSD
   dos Santos, MERA
   da Silva, ML
   do Carmo, TS
   Silva, RKP
   da Silva, KG
   de Souza, SL
   Souza, VDN
AF Souza, Ana Patricia da Silva
   Barros, Waleska Maria Almeida
   Silva, Jose Mauricio Lucas
   Silva, Mariluce Rodrigues Marques
   Silva, Ana Beatriz Januario
   Fernandes, Matheus Santos de Sousa
   dos Santos, Maria Eduarda Rodrigues Alves
   da Silva, Mayara Luclecia
   do Carmo, Taciane Silva
   Silva, Roberta Karlize Pereira
   da Silva, Karollainy Gomes
   de Souza, Sandra Lopes
   Souza, Viviane de Oliveira Nogueira
TI Effect of Metabolic Syndrome on Parkinson's Disease: A Systematic Review
SO CLINICS
LA English
DT Review
DE Metabolic Syndrome; Parkinson Disease; Vascular Risk Factors
ID GAMMA-GLUTAMYL-TRANSFERASE; RISK-FACTORS; ASSOCIATION; COMPONENTS;
   FALLS; MEN
AB Evidence shows that metabolic syndrome (MS) is associated with a greater risk of developing Parkinson's disease (PD) because of the increase in oxidative stress levels along with other factors such as neuroinflammation and mitochondrial dysfunction. However, because some studies have reported that MS is associated with a lower risk of PD, the relationship between MS and PD should be investigated. This study aimed to investigate the effect of MS on PD. Two authors searched five electronic databases, namely, MEDLINE, PubMed, Scopus, PsycINFO, Web of Science, and Science Direct, for relevant articles between September and October 2020. After screening the title and abstract of all articles, 34 articles were selected for full-text review. Finally, 11 articles meeting the eligibility criteria were included in the study. The quality of articles was critically evaluated using the Joanna Briggs Institute. Overall, we evaluated data from 23,586,349 individuals (including healthy individuals, with MS and PD) aged 30 years or more. In cohort studies, the follow-up period varied between 2 and 30 years. MS contributed considerably to the increase in the incidence of PD. In addition, obesity, a component of MS, alone can increase the probability of developing neurodegenerative diseases. However, despite few studies on MS and PD, changes in cognitive function and more rapid progression of PD disease has been documented in patients with MS using methods commonly used in research.
C1 [Souza, Ana Patricia da Silva; Barros, Waleska Maria Almeida; Silva, Mariluce Rodrigues Marques; Silva, Ana Beatriz Januario; Fernandes, Matheus Santos de Sousa; de Souza, Sandra Lopes] Univ Fed Pernambuco, Ctr Ciencias Saude, Programa Posgrad Neuropsiquiatria & Ciencias Comp, Recife, PE, Brazil.
   [Barros, Waleska Maria Almeida; Silva, Jose Mauricio Lucas; dos Santos, Maria Eduarda Rodrigues Alves; da Silva, Mayara Luclecia; do Carmo, Taciane Silva] Ctr Univ Osman Lins UNIFACOL, Ctr Ciencias Saude, Dept Fisioterapia, Vitoria De Santo Antao, PE, Brazil.
   [Barros, Waleska Maria Almeida; Silva, Roberta Karlize Pereira; da Silva, Karollainy Gomes] Ctr Univ Osman Lins UNIFACOL, Ctr Integrado Tecnol Neurociencia CITENC, Vitoria De Santo Antao, PE, Brazil.
   [Souza, Viviane de Oliveira Nogueira] Univ Fed Pernambuco, Ctr Acad Vitoria CAV, Nucl Nutr, Vitoria De Santo Antao, PE, Brazil.
C3 Universidade Federal de Pernambuco; Universidade Federal de Pernambuco
RP Souza, APD (corresponding author), Univ Fed Pernambuco, Ctr Ciencias Saude, Programa Posgrad Neuropsiquiatria & Ciencias Comp, Recife, PE, Brazil.
EM patricia-asb@hotmail.com
RI Souza, Ana/KFB-3039-2024; Fernandes, Matheus/AAI-4950-2020; souza,
   sandra/ABC-4504-2021; Barros, Waleska/AAP-6244-2021
OI Luclecia, Mayara/0000-0002-0686-2635; Silva,
   Roberta/0000-0002-8662-6324; Rodrigues alves dos Santos, Maria
   Eduarda/0000-0001-8546-7280; Mauricio, Jose/0000-0002-4508-3589; Santos
   de Sousa Fernandes, Matheus/0000-0002-1066-9176; , Ana
   Beatriz/0000-0001-7919-647X; Lopes de souza, sandra/0000-0003-4562-6042
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NR 32
TC 5
Z9 5
U1 0
U2 5
PU ELSEVIER ESPANA
PI MADRID
PA CALLE DE ZURBANO, 76-4TH FLR LEFT, MADRID, 28010, SPAIN
SN 1807-5932
EI 1980-5322
J9 CLINICS
JI Clinics
PY 2021
VL 76
AR e3379
DI 10.6061/clinics/2021/e3379
PG 10
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA YI9ZI
UT WOS:000744198700002
PM 34909941
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Tkachenko, OY
   Shayakhmetova, GM
   Matvienko, AV
   Kovalenko, VM
AF Tkachenko, Oleksandr Y.
   Shayakhmetova, Ganna M.
   Matvienko, Anatoliy, V
   Kovalenko, Valentina M.
TI Reproductive disorders in male rats induced by high-fructose consumption
   from juvenile age to puberty
SO ARHIV ZA HIGIJENU RADA I TOKSIKOLOGIJU-ARCHIVES OF INDUSTRIAL HYGIENE
   AND TOXICOLOGY
LA English
DT Article
DE epididymis; fertility; FSH; LH; male reproductive function; metabolic
   syndrome; MetS; sperm count; testes; testosterone
ID INSULIN-RESISTANCE; METABOLIC SYNDROME; OXIDATIVE STRESS; ADOLESCENTS;
   INFERTILITY; OBESITY
AB There is compelling evidence that a hypercaloric, high-fructose diet can cause metabolic syndrome (MetS) and a whole range of other metabolic changes. In the context of androgen deficiency, MetS in boys merits special attention, but the effects of fructose-rich diet in youth on future male reproductive function are still poorly evidenced. The aim of this study was to address this issue and analyse the effects of high-fructose intake starting from weaning to puberty (postnatal day 23 up to 83) on the reproductive function of male rats. For this purpose juvenile male Wistar rats were divided in two groups: control and the group receiving 10 % fructose solution instead of drinking water. Reproductive function was evaluated in terms of fertility, sperm count, testes/epididymis morphology, and serum sex hormones. The fructose-treated group showed a decrease in testosterone and twofold increase in luteinising and follicle-stimulating hormone levels in the serum. This was accompanied with lower testis/epididymis weights, sperm count, and changed testis/epididymis morphology. Their fertility remained unchanged, but the fertility of females mating with these males diminished. In addition, pre-implantation and post-implantation embryonic death rate rose in these females. Our results have confirmed that high fructose consumption from early age until puberty can impair the reproductive function of male rats, and call for further animal and epidemiological investigation.
C1 [Tkachenko, Oleksandr Y.; Shayakhmetova, Ganna M.; Matvienko, Anatoliy, V; Kovalenko, Valentina M.] NAMS Ukraine, Inst Pharmacol & Toxicol, Toxicol Dept, Kiev, Ukraine.
C3 National Academy of Medical Sciences of Ukraine; Institute of
   Pharmacology & Toxicology of the National Academy of Medical Sciences of
   Ukraine
RP Shayakhmetova, GM (corresponding author), NAMS Ukraine, Inst Pharmacol & Toxicol, Toxicol Dept, Kiev, Ukraine.
EM anna_shayakhmetova@yahoo.com
RI Shayakhmetova, Ganna/AAU-2814-2020
OI Tkachenko, Oleksandr/0000-0003-0622-5617; Shayakhmetova,
   Ganna/0000-0002-6504-7067
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NR 44
TC 5
Z9 5
U1 0
U2 6
PU INST MEDICAL RESEARCH & OCCUPATIONAL HEALTH
PI ZAGREB
PA 2 KSAVERSKA ST P O BOX 291, ZAGREB, 00000, CROATIA
SN 0004-1254
EI 1848-6312
J9 ARH HIG RADA TOKSIKO
JI Arh. Hig. Rada. Toksikol.
PD MAR
PY 2020
VL 71
IS 1
BP 78
EP 86
DI 10.2478/aiht-2020-71-3303
PG 9
WC Public, Environmental & Occupational Health; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health; Toxicology
GA LC5DT
UT WOS:000525345900009
PM 32597133
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Bautista, RJH
   Mahmoud, AM
   Königsberg, M
   Guerrero, NELD
AF Hernandez Bautista, Rene J.
   Mahmoud, Ayman M.
   Konigsberg, Mina
   Diaz Guerrero, Norma E. Lopez
TI Obesity: Pathophysiology, monosodium glutamate-induced model and
   anti-obesity medicinal plants
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Review
DE Obesity; Monosodium glutamate; Oxidative stress; Inflammation; Arcuate
   nucleous; Medicinal plants
ID PANCREATIC BETA-CELLS; FREE FATTY-ACIDS; INSULIN-RESISTANCE; OXIDATIVE
   STRESS; METABOLIC SYNDROME; ADIPOSE-TISSUE; MOUSE MODEL; PPAR-GAMMA;
   NONALCOHOLIC STEATOHEPATITIS; INFLAMMATORY CYTOKINES
AB Obesity and overweight have increased at an alarming rate in the world during the last three decades. Obesity is a crucial factor in the development of metabolic abnormalities, including glucose intolerance, insulin resistance, metabolic syndrome, low-grade inflammation and oxidative stress. A similar scinario occurs during the aging process where alterations of the energetic metabolism homeostasis and a chronic systematic low-grade inflammation have been observed. Oxidative stress and poor physical performance can increase the risk of metabolic disease. Despite the diverse studies on the pathophysiological effects of obesity, its impact related to gender and through life, particularly during aging, hasn't received a reasonable attention. The purpose of this review is to outline the pathophysiological mechanisms and metabolic alterations associated with obesity, with an emphasis on the monosodium glutamate (MSG)-induced obese model. MSG-induced obesity associated inflammation and declined adiponectin were more obvious in male mice, while glucose tolerance, insulin sensitivity and the redox balance were altered with increased age of both male and female mice. These findings indicate that the metabolic alterations in MSG-induced obesity are associated with the gender as well as aging. Therefore, the MSG obesity model is of a resonable value to underlie the relationship between gender, aging and metabolic alterations in obesity. In addition, we reviewed the medicinal plants and their active constituents which have been used to treat MSG-induced obesity. Given the significat value of this model, studies are needed to scrutinize the benificial effects and underlying mechanisms of medicinal plants with proven anti-obesity activity.
C1 [Hernandez Bautista, Rene J.; Konigsberg, Mina; Diaz Guerrero, Norma E. Lopez] Metropolitan Autonomous Univ, Div Hlth & Biol Sci, Dept Hlth Sci, Lab Bioenerget & Cellular Aging, Prol Canal Miramontes 3855, Mexico City 14387, Cdmx, Mexico.
   [Mahmoud, Ayman M.] Beni Suef Univ, Physiol Div, Dept Zool, Fac Sci, Bani Suwayf, Egypt.
C3 Universidad Autonoma Metropolitana - Mexico; Egyptian Knowledge Bank
   (EKB); Beni Suef University
RP Bautista, RJH (corresponding author), Metropolitan Autonomous Univ, Div Hlth & Biol Sci, Dept Hlth Sci, Lab Bioenerget & Cellular Aging, Prol Canal Miramontes 3855, Mexico City 14387, Cdmx, Mexico.
EM rjhb11@xanum.uam.mx
RI Lopez-Diazguerrero, Norma/MSW-7061-2025; Mahmoud, Ayman/S-2613-2016
OI Hernandez Bautista, Rene Javier/0000-0001-7065-2862; LOPEZ DIAZ
   GUERRERO, NORMA EDITH/0000-0001-7470-9360; Mahmoud,
   Ayman/0000-0003-0279-6500
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NR 233
TC 84
Z9 90
U1 0
U2 32
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD MAR
PY 2019
VL 111
BP 503
EP 516
DI 10.1016/j.biopha.2018.12.108
PG 14
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA HL5AK
UT WOS:000458737800056
PM 30597304
OA gold
DA 2025-06-11
ER

PT J
AU Sud, N
   Rutledge, AC
   Pan, KC
   Su, QZ
AF Sud, Neetu
   Rutledge, Angela C.
   Pan, Kaichao
   Su, Qiaozhu
TI Activation of the dsRNA-Activated Protein Kinase PKR in Mitochondrial
   Dysfunction and Inflammatory Stress in Metabolic Syndrome
SO CURRENT PHARMACEUTICAL DESIGN
LA English
DT Article
DE dsRNA-Activated Protein Kinase PKR; Mitochondrial dysfunction; ER
   stress; Metaflammation; Metabolic diseases
ID DOUBLE-STRANDED-RNA; ENDOPLASMIC-RETICULUM STRESS; NF-KAPPA-B; LIPOTOXIC
   CELL-DEATH; I IGF-I; TYROSINE PHOSPHORYLATION; INSULIN-RESISTANCE;
   SUBSTRATE RECOGNITION; TRANSLATIONAL CONTROL; DIMERIZATION DOMAINS
AB Background: The double stranded RNA (dsRNA)-activated protein kinase PKR is a well-established protein kinase that is activated by dsRNA during viral infection, and it inhibits global protein synthesis by phosphorylating the alpha subunit of eukaryotic initiation factor 2 alpha (eIF2 alpha). Recent studies have greatly broadened the recognized physiological activities of PKR by demonstrating its fundamental role in inflammatory signaling, particularly in chronic, low-grade inflammation induced by metabolic disorders, known as metaflammation. Metaflammation is initiated by the activation of the NOD-like receptor (NLR), leucine-rich repeat, pyrin domaincontaining 3 (NLRP3) gene by mitochondrial reactive oxygen species (ROS). A protein complex defined as the metaflammasome is assembled in the course of metaflammation. This complex integrates nutritional signaling with cellular stress, inflammatory components, and insulin action and is essential in maintaining metabolic homeostasis. PKR is a key constituent of the metaflammasome and interacts directly with several inflammatory kinases, such as inhibitor kappa B (I kappa B) kinase (IKK) and c-Jun N-terminal kinase (JNK), insulin receptor substrate 1 (IRS1), and component of the translational machinery such as eIF2 alpha. Conclusion: This review highlights recent findings in PKR-mediated metaflammation and its association with the onset of metabolic syndrome in both human and animal models, with a focus on the molecular and biochemical pathways that underlie the progression of obesity, insulin resistance, and type-2 diabetes.
C1 [Sud, Neetu; Pan, Kaichao; Su, Qiaozhu] Univ Nebraska, Dept Nutr & Hlth Sci, Lincoln, NE 68583 USA.
   [Rutledge, Angela C.] London Hlth Sci Ctr, Dept Pathol & Lab Med, London, ON, Canada.
C3 University of Nebraska System; University of Nebraska Lincoln; London
   Health Sciences Centre
RP Su, QZ (corresponding author), Univ Nebraska, 316F Leverton Hall, Lincoln, NE 68583 USA.
EM qsu2@unl.edu
OI Su, Qiaozhu/0000-0001-8434-1408; Rutledge, Angela/0000-0001-9106-316X
FU NIH [P20 GM104320-01A1]
FX This work was supported by a P20 GM104320-01A1 grant award from NIH to
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NR 102
TC 26
Z9 29
U1 1
U2 12
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1381-6128
EI 1873-4286
J9 CURR PHARM DESIGN
JI Curr. Pharm. Design
PY 2016
VL 22
IS 18
BP 2697
EP 2703
DI 10.2174/1381612822666160202141845
PG 7
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA DM6HP
UT WOS:000376452500010
PM 26831644
DA 2025-06-11
ER

PT J
AU Kishina, M
   Koda, M
   Kato, J
   Tokunaga, S
   Matono, T
   Sugihara, T
   Ueki, M
   Murawaki, Y
AF Kishina, Manabu
   Koda, Masahiko
   Kato, Jun
   Tokunaga, Shiho
   Matono, Tomomitsu
   Sugihara, Takaaki
   Ueki, Masaru
   Murawaki, Yoshikazu
TI Therapeutic effects of the direct renin inhibitor, aliskiren, on
   non-alcoholic steatohepatitis in fatty liver Shionogi
   ob/ob male mice
SO HEPATOLOGY RESEARCH
LA English
DT Article
DE direct renin inhibitors; liver fibrosis; liver steatosis; non-alcoholic
   steatohepatitis; oxidative stress
ID TYPE-1 RECEPTOR BLOCKER; BILE-DUCT LIGATION; ANGIOTENSIN SYSTEM;
   HEPATIC-FIBROSIS; INSULIN-RESISTANCE; OXIDATIVE STRESS; INFLAMMATION;
   MOUSE; STEATOSIS; OBESITY
AB Aim: Non-alcoholic steatohepatitis (NASH) is a manifestation of metabolic syndrome in the liver that is characterized by hepatic fat accumulation, inflammation and varying degrees of fibrosis. The renin-angiotensin system (RAS) appears to play important roles in NASH. Direct renin inhibitors (DRI) reduce plasma renin activity (PRA) through interaction with the active site of the enzyme and reduce the formation of angiotensin-II (AT-II). Therefore, the DRI aliskiren may further suppress the RAS. This study examined the effects of aliskiren on NASH in fatty liver Shionogi (FLS)-ob/ob male mice that are the closest animal model of metabolic syndrome-related NASH in humans.
   Methods: Aliskiren (100 mg/kg per day, aliskiren group) or a placebo (control group) was p.o. administrated to eight FLS-ob/ob mice each for 16 weeks and factors including steatosis, fibrosis, inflammation and oxidative stress were compared between the two groups.
   Results: Amounts of hepatic fibrosis were significantly lower in the aliskiren group than in the control group. Areas of alpha-smooth muscle actin positivity, the numbers of F4/80 positive, 8-hydroxy-2-deoxyguanosine positive cells and immunohistochemical staining of 4-hydroxynonenal were also significantly decreased in the aliskiren group. Levels of RNA expression for transforming growth factor-beta 1, connective tissue growth factor and monocyte chemoattractant protein-1 were significantly lower in the aliskiren group.
   Conclusion: Aliskiren attenuated the progression of hepatic fibrosis by inhibiting the activation of hepatic stellate and Kupffer cells and by reducing oxidative stress.
C1 [Kishina, Manabu; Koda, Masahiko; Kato, Jun; Tokunaga, Shiho; Matono, Tomomitsu; Sugihara, Takaaki; Ueki, Masaru; Murawaki, Yoshikazu] Tottori Univ, Fac Med, Dept Multidisciplinary Internal Med, Div Med & Clin Sci, Yonago, Tottori 683, Japan.
C3 Tottori University
RP Koda, M (corresponding author), 36-1 Nishi Machi, Yonago, Tottori 6838504, Japan.
EM masakoda@med.tottori-u.ac.jp
RI Kato, Junya/O-6144-2015
CR Aihara Y, 2013, HEPATOL RES
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NR 26
TC 14
Z9 16
U1 0
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1386-6346
EI 1872-034X
J9 HEPATOL RES
JI Hepatol. Res.
PD AUG
PY 2014
VL 44
IS 8
BP 888
EP 896
DI 10.1111/hepr.12186
PG 9
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA AM6DD
UT WOS:000339951200009
PM 23777387
DA 2025-06-11
ER

PT J
AU Martín-Cordero, L
   García, JJ
   Hinchado, MD
   Bote, E
   Ortega, E
AF Martin-Cordero, L.
   Garcia, J. J.
   Hinchado, M. D.
   Bote, E.
   Ortega, E.
TI Influence of exercise on NA- and Hsp72-induced release of IFNγ by the
   peritoneal suspension of macrophages and lymphocytes from genetically
   obese Zucker rats
SO JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
LA English
DT Article
DE Exercise; Hsp72; IFN gamma; Macrophages; Metabolic syndrome; NA
ID METABOLIC SYNDROME; INDUCED STIMULATION; MURINE MACROPHAGES;
   PHYSICAL-ACTIVITY; INTERFERON-GAMMA; IMMUNE-RESPONSE; DANGER SIGNAL;
   STRESS; NORADRENALINE; INFLAMMATION
AB Regular physical exercise is recognized as a nonpharmacological therapeutic strategy in the treatment of metabolic syndrome, and has been proposed for improving obesity, diabetic status, insulin resistance, and immune response. The aim of the present study was to evaluate the effect of a regular exercise program (treadmill running, 5 days/week for 14 weeks at 35 cm/s for 35 min in the last month) on the release of the pro-inflammatory cytokine interferon gamma (IFN gamma) by peritoneal cells (macrophages and lymphocytes) from obese Zucker rats (fa/fa) in response to noradrenaline (NA) and heat shock proteins of 72 kDa (Hsp72), and the possible adaptation due to training for a bout acute exercise (a single session of 25-35 min at 35 cm/s). In healthy (lean Fa/fa) and obese animals, peritoneal cells released greater concentrations of IFN gamma in response to Hsp72 and lower concentrations in response to NA. The regular exercise training protocol, evaluated in the obese animals, produced a clear change in the regulation of the release of IFN gamma. Peritoneal immune cells from trained animals released more IFN gamma in response to NA, but there was a reduction in the release of IFN gamma in response to Hsp72. In the obese animals, regular exercise caused a change in the inhibitory effect of NA (which now becomes stimulatory) and the stimulatory effect of Hsp72e (which now becomes inhibitory) in relation to the release of IFN gamma. This reflects that Hsp72, induced by the prior release of NA following exercise-induced stress, plays a role in the homeostatic balance of release of IFN gamma by peritoneal immune cells in obese animals during exercise.
C1 [Martin-Cordero, L.; Garcia, J. J.; Hinchado, M. D.; Bote, E.; Ortega, E.] Univ Extremadura, Fac Sci, Dept Physiol, Immunophysiol Res Grp, E-06071 Badajoz, Spain.
   [Ortega, E.] Univ Extremadura, Fac Sci, Dept Physiol, E-06071 Badajoz, Spain.
C3 Universidad de Extremadura; Universidad de Extremadura
RP Ortega, E (corresponding author), Univ Extremadura, Fac Sci, Dept Physiol, E-06071 Badajoz, Spain.
EM orincon@unex.es
RI Ortega, Eduardo/H-9891-2016; Garcia, Juan/C-7383-2013; Martin-Cordero,
   Leticia/H-9711-2015
OI Ortega, Eduardo/0000-0002-7007-7615; Bote, Maria
   Elena/0000-0002-3112-9259; HINCHADO SANCHEZ-MORO, MARIA
   DOLORES/0000-0002-9709-4714; Garcia, Juan/0000-0002-8222-4213;
   Martin-Cordero, Leticia/0000-0002-3651-2265
FU Ministry of Science and Innovation [DEP2006-56187-C04-03]; Junta de
   Extremadura [GRU10020]; FEDER; RETICEF; Fundacion Valhondo de
   Extremadura, Spain
FX This work was partially supported by grants from the Ministry of Science
   and Innovation (DEP2006-56187-C04-03), Junta de Extremadura (GRU10020),
   FEDER, RETICEF, and Fundacion Valhondo de Extremadura, Spain.
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NR 36
TC 8
Z9 9
U1 0
U2 8
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1138-7548
EI 1877-8755
J9 J PHYSIOL BIOCHEM
JI J. Physiol. Biochem.
PD MAR
PY 2013
VL 69
IS 1
BP 125
EP 131
DI 10.1007/s13105-012-0196-5
PG 7
WC Biochemistry & Molecular Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Physiology
GA 088NP
UT WOS:000314842100013
PM 22798210
DA 2025-06-11
ER

PT J
AU Mohebbi, I
   Saadat, S
   Aghassi, M
   Shekari, M
   Matinkhah, M
   Sehat, S
AF Mohebbi, Iraj
   Saadat, Soheil
   Aghassi, Mohammadreza
   Shekari, Mahsa
   Matinkhah, Maghsuod
   Sehat, Shadi
TI Prevalence of Metabolic Syndrome in Iranian Professional Drivers:
   Results from a Population Based Study of 12,138 Men
SO PLOS ONE
LA English
DT Article
ID CORONARY-HEART-DISEASE; CARDIOVASCULAR-DISEASE; RISK-FACTORS; WAIST
   CIRCUMFERENCE; CIGARETTE-SMOKING; UNITED-STATES; MORTALITY; HEALTH;
   IMPACT; EAST
AB Background: It is evident that professional driving is associated with substantial changes in lifestyle habits. Professional drivers are prone to metabolic syndrome (MetS) and its complications because their working environment is characterized by numerous stress factors such as lack of physical activity due to working in a fixed position, disruption in diet, and irregular sleep habits. The aim of the present study was to estimate the prevalence of MetS among long distance drivers residing in West Azerbaijan province in Iran.
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   Results: Among 12138 participants, 3697 subjects found to be MetS. The crude and age-adjusted rates of MetS were 30.5% and 32.4% respectively. Based on Body mass index (BMI), 5027 subjects (41.4%) were overweight (BMI >= 25.01-30 kg/m2), and 2592 (21.3%) were obese (BMI >= 30.01 kg/m2). The presence of central obesity was more common than other components. The associations of MetS with BMI, pack-year smoking, age, weekly driving duration and driving experiences were significant in the logistic regression. By increasing BMI, pack-year smoking, age, weekly driving duration and driving experiences, odds ratio of MetS was increased.
   Conclusion: The study suggests that MetS has become a noteworthy health problem among Iranian long distance drivers. This might be due to the following facts: sitting in a fixed position for long hours while working, cigarette smoking, job stress, unhealthy diet and lack of physical activity. Educational programs should be established for promoting healthy lifestyle and also for early detection and appropriate interventions
C1 [Mohebbi, Iraj; Shekari, Mahsa; Matinkhah, Maghsuod; Sehat, Shadi] Urmia Univ Med Sci, Occupat Med Ctr, Orumiyeh, Iran.
   [Saadat, Soheil] Med Sci Univ Tehran, Sina Hosp, Sina Trauma Res Ctr, Tehran, Iran.
   [Aghassi, Mohammadreza] Urmia Univ Med Sci, Dept Endocrinol, Orumiyeh, Iran.
C3 Urmia University of Medical Sciences; Tehran University of Medical
   Sciences; Urmia University of Medical Sciences
RP Mohebbi, I (corresponding author), Urmia Univ Med Sci, Occupat Med Ctr, Orumiyeh, Iran.
EM irajmohebbi@umsu.ac.ir
RI Mohebbi, Iraj/G-1494-2017; Saadat, Soheil/J-1595-2014
OI Mohebbi, Iraj/0000-0001-9158-5742
CR Ahmad OB, 2001, WHO DISCUSSION PAPER
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NR 34
TC 35
Z9 40
U1 1
U2 10
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD FEB 22
PY 2012
VL 7
IS 2
AR e31790
DI 10.1371/journal.pone.0031790
PG 5
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 926ZZ
UT WOS:000302875500041
PM 22384075
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Cho, Y
   Lim, TH
   Kang, H
   Lee, Y
   Lee, H
   Kim, H
AF Cho, Yongil
   Lim, Tae Ho
   Kang, Hyunggoo
   Lee, Yoonje
   Lee, Heekyung
   Kim, Hongjung
TI Socioeconomic status and depression as combined risk factors for acute
   myocardial infarction and stroke: A population-based study of 2.7
   million Korean adults
SO JOURNAL OF PSYCHOSOMATIC RESEARCH
LA English
DT Article
DE Socioeconomic status; Depression; Acute myocardial infarction; Stroke
ID CORONARY-HEART-DISEASE; CAUSE-SPECIFIC MORTALITY; INTIMA-MEDIA
   THICKNESS; CARDIOVASCULAR-DISEASE; PSYCHOLOGICAL DISTRESS; COMBINED
   ASSOCIATION; METABOLIC SYNDROME; PUBLIC SERVANTS; ALL-CAUSE; SYMPTOMS
AB Objectives: To evaluate the separate and combined associations of socioeconomic status (SES) and depression with the incidences of acute myocardial infarction (AMI) and stroke.
   Methods: We conducted a population-based cohort study using nationwide health insurance claims data collected from 2002 to 2016 in South Korea. A total of 2,705,090 subjects aged 20 years or older for whom had health screening data were collected between 2004 and 2005 were analyzed. The hazard ratios (HRs) for the incidences of AMI and stroke were calculated using Cox proportional regression analyses.
   Results: After adjusting for cardiovascular risk factors, a low SES was associated with increased risks of AMI (HR, 1.16; 95% confidence interval (CI), 1.14-1.19) and stroke (HR, 1.13; 95% CI, 1.11-1.14) incidence. Depression was also associated with an increased incidence of AMI (HR, 1.26; 95% CI, 1.21-1.31) and stroke (HR, 1.24; 95% CI, 1.21-1.27). Patients with depression who had a low SES exhibited significantly increased risks of AMI (HR, 1.47; 95% CI, 1.36-1.60) and stroke (HR, 1.37; 95% CI, 1.30-1.44) compared to patients with a high SES who were not diagnosed with depression. Depression showed a positive effect modification of low and medium SES compared to high SES on the association with AMI but not with stroke.
   Conclusions: Subjects with both a low SES and depression displayed the highest risk. Both SES and depression should be considered in cardiovascular risk assessments, particularly in individuals with depression who have a low SES.
C1 [Cho, Yongil; Lim, Tae Ho; Kang, Hyunggoo; Lee, Yoonje; Lee, Heekyung; Kim, Hongjung] Hanyang Univ, Coll Med, Dept Emergency Med, 222 Wangsimni Ro St, Seoul 04763, South Korea.
C3 Hanyang University
RP Lim, TH (corresponding author), Hanyang Univ, Coll Med, Dept Emergency Med, 222 Wangsimni Ro St, Seoul 04763, South Korea.
EM erthim@gmail.com
RI Cho, Yongil/LZF-3835-2025; Cho, Yongil/R-7828-2016; LEE,
   YOONJE/R-7311-2016
OI Lim, Tae Ho/0000-0003-1045-413X; Cho, Yongil/0000-0001-5027-6345; LEE,
   YOONJE/0000-0001-6478-7568; Kim, Hongjung/0000-0003-4003-8612
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NR 41
TC 23
Z9 27
U1 0
U2 13
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-3999
EI 1879-1360
J9 J PSYCHOSOM RES
JI J. Psychosomat. Res.
PD JUN
PY 2019
VL 121
BP 14
EP 23
DI 10.1016/j.jpsychores.2019.01.016
PG 10
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA IB1RF
UT WOS:000470041600005
PM 30712815
DA 2025-06-11
ER

PT J
AU Kamari, Y
   Grossman, E
   Oron-Herman, M
   Peleg, E
   Shabtay, Z
   Shamiss, A
   Sharabi, Y
AF Kamari, Y.
   Grossman, E.
   Oron-Herman, M.
   Peleg, E.
   Shabtay, Z.
   Shamiss, A.
   Sharabi, Y.
TI Metabolic stress with a high carbohydrate diet increases adiponectin
   levels
SO HORMONE AND METABOLIC RESEARCH
LA English
DT Article
DE adiponectin; metabolic syndrome; carbohydrates; diet
ID INDUCED INSULIN-RESISTANCE; ADIPOSE-SPECIFIC PROTEIN; LOW-CALORIE DIET;
   CIRCULATING ADIPONECTIN; GENE-EXPRESSION; BLOOD-PRESSURE; OBESE WOMEN;
   ASSOCIATION; RECEPTOR; SUCROSE
AB Background: Adiponectin is an adipose tissue-specific protein, which possesses anti-atherogenic and antidiabetic properties, yet its plasma levels are decreased in subjects with metabolic syndrome. Although high fat diet has been linked to hypoadiponectinemia, the effect of high-carbohydrate diet on adiponectin levels is not known. Therefore, we studied the effect of high-carbohydrate diet on adiponectin levels in the rat models of hypertension and insulin resistance.
   Methods: Rats were randomly assigned to the high carbohydrate diet [Sprague-Dawley rats with fructose enriched diet (SDR-F) and spontaneously hypertensive rats with sucrose enriched diet (SHR-S model)] or chow diet (Control group). Rats were followed for 6 weeks (SDR-F model) and 8 weeks (SHR-S model). Body weight, systolic blood pressure, plasma levels of glucose, insulin, triglycerides and adiponectin, were recorded.
   Results: Both models were associated with features of the metabolic syndrome, namely, high insulin levels, increased blood pressure and triglyceride levels. Plasma adiponectin levels did not change in the control groups. In contrast, adiponectin levels increased by 39 and 30% compared to baseline following four and six weeks of fructose enriched diet in SDR (from 3.3 +/- 0.2 to 4.5 +/- 0.4 and 4.3 +/- 0.2 mu g/ml, respectively, p < 0.05). Likewise, five and eight weeks of sucrose enriched diet in SHR, induced a 54 and 81% increase in adiponectin levels compared to baseline (from 4.2 +/- 0.3 to 6.3 +/- 0.3 and 7.3 +/- 0.5 mu g/ml, respectively, p < 0.01).
   Conclusion: Metabolic stress with a high-carbohydrate diet increases plasma levels of adiponectin. Further studies will elucidate whether this is a transitory compensatory mechanism or a sign of target organ resistance to adiponectin.
C1 Chaim Sheba Med Ctr, Hypertens Unit, IL-52621 Tel Hashomer, Israel.
   Tel Aviv Univ, Sackler Fac Med, IL-69978 Tel Aviv, Israel.
   NINDS, NIH, Bethesda, MD 20892 USA.
C3 Chaim Sheba Medical Center; Tel Aviv University; Sackler Faculty of
   Medicine; National Institutes of Health (NIH) - USA; NIH National
   Institute of Neurological Disorders & Stroke (NINDS)
RP Kamari, Y (corresponding author), Chaim Sheba Med Ctr, Hypertens Unit, IL-52621 Tel Hashomer, Israel.
EM yehuda.kamari@sheba.health.gov.il
OI Grossman, Ehud/0000-0001-8353-0661
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NR 46
TC 38
Z9 43
U1 0
U2 10
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0018-5043
EI 1439-4286
J9 HORM METAB RES
JI Horm. Metab. Res.
PD MAY
PY 2007
VL 39
IS 5
BP 384
EP 388
DI 10.1055/s-2007-976534
PG 5
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 179CX
UT WOS:000247268000012
PM 17533582
DA 2025-06-11
ER

PT J
AU Gulley, LD
   Shomaker, LB
   Kelly, NR
   Chen, KY
   Olsen, CH
   Tanofsky-Kraff, M
   Yanovski, JA
AF Gulley, Lauren D.
   Shomaker, Lauren B.
   Kelly, Nichole R.
   Chen, Kong Y.
   Olsen, Cara H.
   Tanofsky-Kraff, Marian
   Yanovski, Jack A.
TI Examining cognitive-behavioral therapy change mechanisms for decreasing
   depression, weight, and insulin resistance in adolescent girls at risk
   for type 2 diabetes
SO JOURNAL OF PSYCHOSOMATIC RESEARCH
LA English
DT Article
DE Adolescent psychotherapy; Depression (emotion); Metabolic syndrome;
   Obesity; Randomized controlled trials
ID PREVENTION PROGRAM; SYMPTOMS; ACTIVATION; TRIAL; POPULATION; VALIDATION;
   PARAMETERS; CHILDREN; GLUCOSE; OBESITY
AB Objective: Depression in adolescence is linked to risk for type 2 diabetes (T2D). In this secondary data analysis of a randomized controlled trial comparing cognitive-behavioral therapy (CBT) to a control program to ameliorate insulin resistance via reducing depression symptoms, we examine which CBT change mechanisms (e.g., behavioral activation, cognitive restructuring) contributed to decreased depression and subsequent improvements in body mass index (BMI), percent body fat, and insulin resistance. Methods: Girls 12-17y with overweight/obesity and family history of T2D were randomized to six-week group CBT (n = 61) or health education (HealthEd; n = 58). At baseline and post-treatment, adolescents completed questionnaires assessing activities, thoughts, and depression symptoms. At baseline, post-treatment, and one-year, BMI was calculated and insulin outcomes were derived from two-hour oral glucose tolerance testing. At baseline and one-year, percent body fat was assessed with dual-energy x-ray absorptiometry. Indirect effects of CBT components were tested on one-year changes in BMI, percent body fat, and insulin indices through decreases in depression symptoms during treatment. Intervention was tested as a moderator. Results: In CBT, but not HealthEd, there was an indirect effect of increased physical activity during treatment on decreased one-year BMI via reductions in depression symptoms during treatment. Also, there were conditional indirect effects in CBT of increased pleasantness of physical and social activity during treatment on decreased one-year BMI via decreased depression symptoms during treatment. Conclusion: Behavioral activation may be a useful intervention to decrease depression and reduce excess weight gain in the targeted prevention of T2D in at-risk adolescent girls. NCT01425905, clinicaltrials.gov
C1 [Gulley, Lauren D.; Shomaker, Lauren B.] Colorado State Univ, Human Dev & Family Studies, Campus Delivery 1570, Ft Collins, CO 80523 USA.
   [Gulley, Lauren D.; Shomaker, Lauren B.] Univ Colorado, Childrens Hosp Colorado, Pediat, Sect Endocrinol, Anschutz Med Campus,13123 E 16th Ave,B265, Aurora, CO 80045 USA.
   [Shomaker, Lauren B.; Kelly, Nichole R.; Tanofsky-Kraff, Marian; Yanovski, Jack A.] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Sect Growth & Obes, Div Intramural Res, NIH, 10 Ctr Dr, Bethesda, MD 20892 USA.
   [Kelly, Nichole R.] Univ Oregon, Coll Educ, Counseling Psychol & Human Serv & Prevent Sci Ins, 1215 Univ Oregon, Eugene, OR 97403 USA.
   [Chen, Kong Y.] NIDDK, Diabet Endocrinol & Obes Branch, NIH, 10 Ctr Dr, Bethesda, MD 20892 USA.
   [Olsen, Cara H.] Uniformed Serv Univ Hlth Sci, Preventat Med & Biometr, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA.
   [Tanofsky-Kraff, Marian] Uniformed Serv Univ Hlth Sci, Med & Clin Psychol, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA.
C3 Colorado State University System; Colorado State University Fort
   Collins; Children's Hospital Colorado; University of Colorado System;
   University of Colorado Anschutz Medical Campus; National Institutes of
   Health (NIH) - USA; Division of Intramural Research (DIR); NIH Eunice
   Kennedy Shriver National Institute of Child Health & Human Development
   (NICHD); University of Oregon; National Institutes of Health (NIH) -
   USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases
   (NIDDK); Uniformed Services University of the Health Sciences - USA;
   Uniformed Services University of the Health Sciences - USA
RP Gulley, LD (corresponding author), 1570 Campus Delivery, Ft Collins, CO 80523 USA.
EM lauren.gulley@colostate.edu
RI Chen, Kong/L-6972-2017
OI Yanovski, Jack/0000-0001-8542-1637; Kelly, Nichole/0000-0003-0812-4182
FU Eunice Kennedy Shriver National Institute of Child Health and Human
   Development (NICHD) [K99HD069516, R00HD069516]; National Institute of
   Health (NIH) Intramural Research Program Grant from NICHD
   [1ZIAHD000641]; NIH Bench to Bedside Program; Office of Behavioral &
   Social Sciences Research; NIH Office of Disease Prevention
FX This work was supported by the Eunice Kennedy Shriver National Institute
   of Child Health and Human Development (NICHD) (Grant #K99HD069516 and
   R00HD069516) ; the National Institute of Health (NIH) Intramural
   Research Program Grant from NICHD (Grant #1ZIAHD000641) to JAY, with
   supplemental funding from the NIH Bench to Bedside Program to LBS, MT-K,
   and JAY; Office of Behavioral & Social Sciences Research to JAY; and NIH
   Office of Disease Prevention to JAY.
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NR 49
TC 8
Z9 9
U1 1
U2 11
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-3999
EI 1879-1360
J9 J PSYCHOSOM RES
JI J. Psychosomat. Res.
PD JUN
PY 2022
VL 157
AR 110781
DI 10.1016/j.jpsychores.2022.110781
EA MAR 2022
PG 10
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 1C6UW
UT WOS:000793252500006
PM 35367918
OA Bronze, Green Accepted
DA 2025-06-11
ER

PT J
AU Lucka, A
   Arabska, J
   Fife, E
   Kroc, L
   Soltysik, BK
   Kloszewska, I
   Sobów, T
   Kostka, T
   Wysokinski, A
AF Lucka, Anna
   Arabska, Jasmina
   Fife, Elizaveta
   Kroc, Lukasz
   Soltysik, Bartlomiej Konrad
   Kloszewska, Iwona
   Sobow, Tomasz
   Kostka, Tomasz
   Wysokinski, Adam
TI Atherogenic Indices Are Increased in Elderly Patients with Unipolar
   Depression-Case-Control Analysis
SO METABOLIC SYNDROME AND RELATED DISORDERS
LA English
DT Article
DE lipids; cholesterol; triglycerides; atherogenic indices; depression; old
   age psychiatry
ID LATE-LIFE DEPRESSION; MAJOR DEPRESSION; LIPID-LEVELS;
   DENSITY-LIPOPROTEIN; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   SERUM-CHOLESTEROL; MOOD DISORDERS; SYMPTOMS; ASSOCIATION
AB Background: Blood lipids are widely used in monitoring the risk of cardiovascular diseases; however, atherogenic indices are more precise markers. The aim of the study was to determine differences in atherogenic indices in elderly patients with unipolar depression (DEP) compared with nondepressed elderly patients (nonDEP) using case-control analysis.
   Methods: Fasting serum lipid profiles were measured in 564 (depressed: n = 282, nondepressed: n = 282, 83.7% (n = 236) women in both groups) Caucasian inpatients aged >= 60, with mean age 76.9 years. Patients from both groups were matched for age and sex. Atherogenic index of plasma (AIP) was calculated as log(10)(triglycerides/ HDL cholesterol). Castelli atherogenic indices were calculated as follows: AILDL/HDL is the ratio of low-density lipoprotein (LDL) cholesterol to high-density lipoprotein (HDL) cholesterol and AI(TC/HDL) is the ratio of total cholesterol to HDL cholesterol.
   Results: HDL levels were significantly decreased in depressed patients (48.2 +/- 14.4mg/dL vs. 54.5 +/- 17.7mg/dL). No other differences in lipid profile were found. We found that all three analyzed atherogenic indices were increased in depressed patients (AIP: 0.41 +/- 0.28 vs. 0.33 +/- 0.27, AI(LDL/HDL): 2.90 +/- 1.41 vs. 2.42 +/- 1.07, AI(TC/HDL): 4.51 +/- 1.84 vs. 3.79 +/- 1.21). We found associations between depression severity and reduced level of HDL (beta=-0.02) or increased AIP (beta = 1.66).
   Conclusions: All three atherogenic indices were increased in elderly patients with depression. Since depression and age are associated with elevated risk of cardiovascular events, elderly patients with depression should be carefully monitored for abnormal lipid status to reduce their cardiovascular risk. The role of lipid abnormalities in the pathogenesis of depression requires further studies.
C1 [Lucka, Anna; Arabska, Jasmina; Kloszewska, Iwona; Wysokinski, Adam] Med Univ Lodz, Dept Old Age Psychiat & Psychot Disorders, Czechoslowacka 8-10, PL-92216 Lodz, Poland.
   [Fife, Elizaveta; Kroc, Lukasz; Soltysik, Bartlomiej Konrad; Kostka, Tomasz] Med Univ Lodz, Dept Geriatr, Lodz, Poland.
   [Sobow, Tomasz] Med Univ Lodz, Dept Med Psychol, Lodz, Poland.
C3 Medical University Lodz; Medical University Lodz; Medical University
   Lodz
RP Wysokinski, A (corresponding author), Med Univ Lodz, Dept Old Age Psychiat & Psychot Disorders, Czechoslowacka 8-10, PL-92216 Lodz, Poland.
EM adam.wysokinski@umed.lodz.pl
RI Wysokinski, Adam/S-9294-2016; Wysokinski, Adam/G-8174-2014; Soltysik,
   Bartlomiej K./S-9839-2016
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NR 42
TC 8
Z9 8
U1 1
U2 8
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-4196
EI 1557-8518
J9 METAB SYNDR RELAT D
JI Metab. Syndr. Relat. Disord.
PD AUG
PY 2017
VL 15
IS 6
BP 291
EP 295
DI 10.1089/met.2017.0008
PG 5
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Research & Experimental Medicine
GA FB9MU
UT WOS:000406464000007
PM 28402173
DA 2025-06-11
ER

PT J
AU Hanefeld, M
   Pistrosch, F
   Bornstein, SR
   Birkenfeld, AL
AF Hanefeld, Markolf
   Pistrosch, Frank
   Bornstein, Stefan R.
   Birkenfeld, Andreas L.
TI The metabolic vascular syndrome - guide to an individualized treatment
SO REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
LA English
DT Review
DE Metabolic syndrome; Type 2 diabetes; Treatment; OAD
ID TYPE-2 DIABETES-MELLITUS; CARDIOVASCULAR RISK-FACTORS; HEPATIC
   INSULIN-RESISTANCE; BARIATRIC SURGERY; ADIPOSE-TISSUE; DOUBLE-BLIND;
   ENDOTHELIAL DYSFUNCTION; MYOCARDIAL-INFARCTION; NATRIURETIC PEPTIDES;
   SECONDARY PREVENTION
AB In ancient Greek medicine the concept of a distinct syndrome (going together) was used to label 'a group of signs and symptoms' that occur together and 'characterize a particular abnormality and condition'. The (dys)metabolic syndrome is a common cluster of five pre-morbid metabolic-vascular risk factors or diseases associated with increased cardiovascular morbidity, fatty liver disease and risk of cancer. The risk for major complications such as cardiovascular diseases, NASH and some cancers develops along a continuum of risk factors into clinical diseases. Therefore we still include hyperglycemia, visceral obesity, dyslipidemia and hypertension as diagnostic traits in the definition according to the term 'deadly quartet'. From the beginning elevated blood pressure and hyperglycemia were core traits of the metabolic syndrome associated with endothelial dysfunction and increased risk of cardiovascular disease. Thus metabolic and vascular abnormalities are in extricable linked. Therefore it seems reasonable to extend the term to metabolic-vascular syndrome (MVS) to signal the clinical relevance and related risk of multimorbidity. This has important implications for integrated diagnostics and therapeutic approach. According to the definition of a syndrome the rapid global rise in the prevalence of all traits and comorbidities of the MVS is mainly caused by rapid changes in life-style and sociocultural transition resp. with over- and malnutrition, low physical activity and social stress as a common soil.
C1 [Hanefeld, Markolf; Pistrosch, Frank; Birkenfeld, Andreas L.] GWT TU Dresden GmbH, Fiedlerstr 34, D-01307 Dresden, Germany.
   [Hanefeld, Markolf; Pistrosch, Frank; Bornstein, Stefan R.; Birkenfeld, Andreas L.] Univ Klinikum Carl Gustav Carus, Med Klin 3, Fetscherstr 74, D-01307 Dresden, Germany.
   [Bornstein, Stefan R.; Birkenfeld, Andreas L.] Kings Coll London, Rayne Inst, Sect Diabet & Nutr Sci, Denmark Hill Campus, London, England.
   [Bornstein, Stefan R.; Birkenfeld, Andreas L.] Tech Univ Dresden, Univ Hosp, Paul Langerhans Inst Dresden, Helmholtz Ctr Munich, Dresden, Germany.
   [Bornstein, Stefan R.; Birkenfeld, Andreas L.] Tech Univ Dresden, Fac Med, Dresden, Germany.
   [Bornstein, Stefan R.; Birkenfeld, Andreas L.] German Ctr Diabet Res DZD eV, Neuherberg, Germany.
C3 Technische Universitat Dresden; Technische Universitat Dresden; Carl
   Gustav Carus University Hospital; University of London; King's College
   London; Technische Universitat Dresden; Carl Gustav Carus University
   Hospital; Helmholtz Association; Helmholtz-Center Munich - German
   Research Center for Environmental Health; Technische Universitat
   Dresden; German Center for Diabetes Research (DZD)
RP Birkenfeld, AL (corresponding author), GWT TU Dresden GmbH, Fiedlerstr 34, D-01307 Dresden, Germany.; Birkenfeld, AL (corresponding author), Univ Klinikum Carl Gustav Carus, Med Klin 3, Fetscherstr 74, D-01307 Dresden, Germany.; Birkenfeld, AL (corresponding author), Kings Coll London, Rayne Inst, Sect Diabet & Nutr Sci, Denmark Hill Campus, London, England.; Birkenfeld, AL (corresponding author), Tech Univ Dresden, Univ Hosp, Paul Langerhans Inst Dresden, Helmholtz Ctr Munich, Dresden, Germany.; Birkenfeld, AL (corresponding author), Tech Univ Dresden, Fac Med, Dresden, Germany.; Birkenfeld, AL (corresponding author), German Ctr Diabet Res DZD eV, Neuherberg, Germany.
EM andreas.birkenfeld@uniklinikum-dresden.de
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NR 151
TC 30
Z9 31
U1 0
U2 6
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1389-9155
EI 1573-2606
J9 REV ENDOCR METAB DIS
JI Rev. Endocr. Metab. Disord.
PD MAR
PY 2016
VL 17
IS 1
BP 5
EP 17
DI 10.1007/s11154-016-9345-4
PG 13
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA DN2IR
UT WOS:000376887800002
PM 26956847
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Caimi, G
   Hopps, E
   Montana, M
   Carollo, C
   Calandrino, V
   Gallà, E
   Canino, B
   Lo Presti, R
AF Caimi, Gregorio
   Hopps, Eugenia
   Montana, Maria
   Carollo, Caterina
   Calandrino, Vincenzo
   Galla, Eleonora
   Canino, Baldassare
   Lo Presti, Rosalia
TI Behaviour of carbonyl groups in several clinical conditions: Analysis of
   our survey
SO CLINICAL HEMORHEOLOGY AND MICROCIRCULATION
LA English
DT Article
DE Oxidative stress; arterial hypertension; metabolic syndrome; juvenile
   myocardial infarction; chronic kidney failure
ID OXIDATION PROTEIN PRODUCTS; OBSTRUCTIVE SLEEP-APNEA; TOTAL ANTIOXIDANT
   STATUS; LIPID-PEROXIDATION; METABOLIC SYNDROME; END-PRODUCTS;
   CARDIOVASCULAR-DISEASE; MYOCARDIAL-INFARCTION; STRESS BIOMARKERS;
   PHYSICAL-ACTIVITY
AB Protein carbonylation is a marker of oxidative protein damage, that is likely involved in the pathogenesis of several diseases. The aim of this study was to evaluate the protein carbonyl (PC) groups in different clinical conditions. It included different groups of subjects: 81 trained subjects; 23 subjects with mild essential hypertension; 31 middle-aged subjects with metabolic syndrome (MS); 106 subjects with MS not selected for age (subdivided into two subgroups, with and without diabetes mellitus); 91 obese adults subdivided in two subgroups (BMI 30-35 Kg/m(2) and BMI > 35 kg/m(2)); 48 subjects with obstructive sleep apnea syndrome (OSAS) subdivided in accordance with the apnea/hypopnea index (AHI); 27 subjects with chronic kidney disease (CKD) on conservative therapy; 31 subjects with CKD on haemodialysis treatment; and 50 subjects with juvenile myocardial infarction. PC groups were reduced in trained subjects in comparison with sedentary controls, while no variation was observed in mild essential hypertension. PC groups were increased in MS subjects and in adult obese subjects. In MS subjects the PC groups were not influenced by the presence of diabetes mellitus and in adult obese subjects were not influenced by the obesity degree. In OSAS subjects only those with AHI > 30 showed an increase of PC groups. PC groups increased in CKD subjects undergoing conservative treatment and haemodialysis therapy. In dialyzed subjects, after a standard dialysis session, there was a marked increase in PC groups. In juvenile myocardial infarction PC groups were higher than in controls; there was no difference between STEMI and NSTEMI and their concentration was unaffected by the number of cardiovascular risk factors or stenosed coronary vessels.
C1 [Caimi, Gregorio; Hopps, Eugenia; Montana, Maria; Carollo, Caterina; Calandrino, Vincenzo; Galla, Eleonora; Canino, Baldassare] Univ Palermo, Dept Hlth Promot Mother & Child Care, Internal Med & Med Specialties, Via Vespro 129, I-90100 Palermo, Italy.
   [Lo Presti, Rosalia] Univ Palermo, Dept Psychol Educ Sci & Human Movement, Palermo, Italy.
C3 University of Palermo; University of Palermo
RP Caimi, G (corresponding author), Univ Palermo, Dept Hlth Promot Mother & Child Care, Internal Med & Med Specialties, Via Vespro 129, I-90100 Palermo, Italy.
EM gregorio.caimi@unipa.it
RI Carollo, Caterina/AAT-3063-2021; Montaña, Fernanda/ADG-6031-2022;
   Presti, Rosalia/J-5394-2016
OI CAROLLO, Caterina/0000-0002-6767-8823
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NR 96
TC 5
Z9 6
U1 0
U2 2
PU IOS PRESS
PI AMSTERDAM
PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS
SN 1386-0291
EI 1875-8622
J9 CLIN HEMORHEOL MICRO
JI Clin. Hemorheol. Microcirc.
PY 2020
VL 74
IS 3
BP 299
EP 313
DI 10.3233/CH-190689
PG 15
WC Hematology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Hematology; Cardiovascular System & Cardiology
GA OR2EC
UT WOS:000589286900008
PM 31683469
OA Green Published
DA 2025-06-11
ER

PT J
AU Godala, MM
   Materek-Kusmierkiewicz, I
   Moczulski, D
   Rutkowski, M
   Szatko, F
   Gaszynska, E
   Tokarski, S
   Kowalski, J
AF Godala, Malgorzata M.
   Materek-Kusmierkiewicz, Izabela
   Moczulski, Dariusz
   Rutkowski, Maciej
   Szatko, Franciszek
   Gaszynska, Ewelina
   Tokarski, Slawomir
   Kowalski, Jan
TI Lower Plasma Levels of Antioxidant Vitamins in Patients with Metabolic
   Syndrome: A Case Control Study
SO ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE
LA English
DT Article
DE metabolic syndrome; diet; oxidative stress; antioxidant vitamins
ID SERUM ALPHA-TOCOPHEROL; OXIDATIVE STRESS; BETA-CAROTENE;
   ALCOHOL-CONSUMPTION; RISK; DIET; DETERMINANTS; PREVALENCE; DISEASE;
   SMOKING
AB Background. Metabolic syndrome (MS) is a coexistence of metabolic risk factors affecting the development of cardiovascular diseases. Reactive oxygen species, which are excessively produced in MS, participate in its pathogenesis. Vitamins A, C and E are an important part of the non-enzymatic antioxidative barrier in humans.
   Objectives. The aim of the study was to estimate plasma vitamin A, C and E levels and the intake of these vitamins from the diet in patients with MS.
   Material and Methods. The study included 182 patients with MS, 94 men and 88 women, aged 30-65 years (mean 57.31 +/- 8.28 years). The control group was comprised of 91 subjects, 56 men and 35 women, aged 41-65 years (mean 57.75 +/- 5.84 years). The MS diagnosis was based on IDF criteria. The determination of the serum level of vitamin A, C and E was performed using the spectrophotometric method. The food intake was assessed by 24-h dietary recall.
   Results. The mean plasma vitamin A, C and E levels were significantly lower in MS patients than in the controls (p = 0.05). No correlation was found between vitamin A, C and E intake from the diet and their plasma concentrations in MS patients. Plasma vitamin A, C and E deficiency was observed significantly more often in MS patients than in the control group (15.38% vs. 2.19%, 79.12% vs. 8.79% and 60.45% vs. 5.49%, p < 0.0001, respectively). BMI was the one factor significantly affecting the mean value of vitamin A, C and E levels in MS patients.
   Conclusions. MS patients demonstrated significantly lower plasma levels of vitamin A, C and E compared to the healthy subjects. Lower plasma levels of antioxidant vitamins with their high intake from the diet indicate antioxidant barrier impairment in MS patients
C1 [Godala, Malgorzata M.] Med Univ Lodz, Chair Hyg & Epidemiol, Dept Nutr & Epidemiol, Lodz, Poland.
   [Materek-Kusmierkiewicz, Izabela; Moczulski, Dariusz] Med Univ Lodz, Chair Internal Dis & Cardiol, Dept Internal Med & Nephrodiabetol, Lodz, Poland.
   [Rutkowski, Maciej] Med Univ Lodz, Dept Mil Toxicol & Radiol Protect, Lodz, Poland.
   [Szatko, Franciszek; Gaszynska, Ewelina] Med Univ Lodz, Chair Hyg & Epidemiol, Dept Hyg & Hlth Promot, Lodz, Poland.
   [Tokarski, Slawomir] Univ Rzeszow, Fac Med, Rzeszow, Poland.
   [Kowalski, Jan] Med Univ Lodz, Dept Internal & Infect Dis, Lodz, Poland.
C3 Medical University Lodz; Medical University Lodz; Medical University
   Lodz; Medical University Lodz; University of Rzeszow; Medical University
   Lodz
RP Godala, MM (corresponding author), Med Univ Lodz, Dept Nutr & Epidemiol, Ul Romanowska 55H-6, PL-91174 Lodz, Poland.
EM malgorzata.godala@umed.lodz.pl
RI Rutkowski, Maciej/S-9910-2016; Kowalski, Jan/HDM-3504-2022; Gaszynska,
   Ewelina/S-9946-2016; Godala, Malgorzata/S-9597-2016
OI Tokarski, Slawomir/0000-0003-1153-0667; Gaszynska,
   Ewelina/0000-0001-7568-3502; Materek-Kusmierkiewicz,
   Izabela/0000-0001-5912-4516; Moczulski, Dariusz/0000-0002-0926-9909;
   Godala, Malgorzata/0000-0003-3579-8537
FU Medical University in Lodz [502-03/6-024-02/502-64-050]
FX The study was financed by the Medical University in Lodz (research task
   No: 502-03/6-024-02/502-64-050).
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NR 47
TC 29
Z9 29
U1 0
U2 3
PU WROCLAW MEDICAL UNIV
PI WROCLAW
PA UL K MARCINKOWSKIEGO 2-6, WROCLAW, 50-368, POLAND
SN 1899-5276
EI 2451-2680
J9 ADV CLIN EXP MED
JI Adv. Clin. Exp. Med.
PD JUL-AUG
PY 2016
VL 25
IS 4
BP 689
EP 700
DI 10.17219/acem/41049
PG 12
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA DY0XX
UT WOS:000384820600012
PM 27629843
OA Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Kolodkin, A
   Sahin, N
   Phillips, A
   Hood, SR
   Bruggeman, FJ
   Westerhoff, HV
   Plant, N
AF Kolodkin, Alexey
   Sahin, Nilgun
   Phillips, Anna
   Hood, Steve R.
   Bruggeman, Frank J.
   Westerhoff, Hans V.
   Plant, Nick
TI Optimization of stress response through the nuclear receptor-mediated
   cortisol signalling network
SO NATURE COMMUNICATIONS
LA English
DT Article
ID PREGNANE-X RECEPTOR; GLUCOCORTICOID-RECEPTOR; TRANSCRIPTIONAL
   REGULATION; METABOLIC SYNDROME; DOWN-REGULATION; CYP3A4; GENE; ALPHA;
   PXR; IDENTIFICATION
AB It is an accepted paradigm that extended stress predisposes an individual to pathophysiology. However, the biological adaptations to minimize this risk are poorly understood. Using a computational model based upon realistic kinetic parameters we are able to reproduce the interaction of the stress hormone cortisol with its two nuclear receptors, the high-affinity glucocorticoid receptor and the low-affinity pregnane X-receptor. We demonstrate that regulatory signals between these two nuclear receptors are necessary to optimize the body's response to stress episodes, attenuating both the magnitude and duration of the biological response. In addition, we predict that the activation of pregnane X-receptor by multiple, lowaffinity endobiotic ligands is necessary for the significant pregnane X-receptor-mediated transcriptional response observed following stress episodes. This integration allows responses mediated through both the high and low-affinity nuclear receptors, which we predict is an important strategy to minimize the risk of disease from chronic stress.
C1 [Kolodkin, Alexey] Univ Luxembourg, Luxembourg Ctr Syst Biomed, L-4362 Esch Sur Alzette, Luxembourg.
   [Sahin, Nilgun; Bruggeman, Frank J.; Westerhoff, Hans V.] Vrije Univ Amsterdam, Netherlands Inst Syst Biol, NL-1081 HV Amsterdam, Netherlands.
   [Phillips, Anna; Plant, Nick] Univ Surrey, Fac Hlth & Med Sci, Ctr Toxicol, Guildford GU2 7XH, Surrey, England.
   [Hood, Steve R.] GlaxoSmithKline, GOLD, Ware SG12 0DP, Herts, England.
   [Bruggeman, Frank J.] Netherlands Inst Syst Biol, Regulatory Networks Grp, NL-1081 HV Amsterdam, Netherlands.
   [Bruggeman, Frank J.] CWI, Ctr Math & Comp Sci, NL-1098 XG Amsterdam, Netherlands.
   [Westerhoff, Hans V.] Univ Manchester, Manchester Ctr Integrat Syst Biol, Manchester Interdisciplinary Bioctr, Manchester M1 7DN, Lancs, England.
   [Westerhoff, Hans V.] Univ Amsterdam, Swammerdam Inst Life Sci, Netherlands Inst Syst Biol, NL-1098 XH Amsterdam, Netherlands.
C3 University of Luxembourg; Vrije Universiteit Amsterdam; University of
   Surrey; GlaxoSmithKline; Glaxosmithkline United Kingdom; Centrum
   Wiskunde & Informatica (CWI); University of Manchester; University of
   Amsterdam
RP Plant, N (corresponding author), Univ Surrey, Fac Hlth & Med Sci, Ctr Toxicol, Guildford GU2 7XH, Surrey, England.
EM N.Plant@Surrey.ac.uk
RI Whittaker, Anna/A-3577-2013; Bruggeman, Frank/AAS-8371-2020; Plant,
   Nick/E-4510-2011; Kolodkin, Alexey/AFL-8732-2022; Bruggeman,
   Frank/C-4356-2015; Westerhoff, Hans/I-5762-2012
OI Plant, Nick/0000-0003-4332-8308; Kolodkin, Alexey/0000-0002-7466-5027;
   Bruggeman, Frank/0000-0002-0255-4766; Westerhoff,
   Hans/0000-0002-0443-6114
FU European Commission [MRTN-CT-2005-019496]; Nederlandse organisatie voor
   internationalisering in het hoger onderwijs (NUFFIC); Biotechnology and
   Biosciences Research Council UK (BBSRC); GlaxoSmithKline
FX This work was supported by the European Commission
   (MRTN-CT-2005-019496), Nederlandse organisatie voor internationalisering
   in het hoger onderwijs (NUFFIC), Biotechnology and Biosciences Research
   Council UK (BBSRC) and GlaxoSmithKline.
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NR 40
TC 22
Z9 24
U1 0
U2 15
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 2041-1723
J9 NAT COMMUN
JI Nat. Commun.
PD APR
PY 2013
VL 4
AR 1792
DI 10.1038/ncomms2799
PG 8
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 143MR
UT WOS:000318872100149
PM 23653204
OA Green Published, Green Submitted, hybrid
DA 2025-06-11
ER

PT J
AU Khalil, M
   Shanmugam, H
   Abdallah, H
   Britto, JSJ
   Galerati, I
   Gómez-Ambrosi, J
   Frühbeck, G
   Portincasa, P
AF Khalil, Mohamad
   Shanmugam, Harshitha
   Abdallah, Hala
   Britto, Jerlin Stephy John
   Galerati, Ilaria
   Gomez-Ambrosi, Javier
   Fruhbeck, Gema
   Portincasa, Piero
TI The Potential of the Mediterranean Diet to Improve Mitochondrial
   Function in Experimental Models of Obesity and Metabolic Syndrome
SO NUTRIENTS
LA English
DT Review
DE obesity; mitochondria; Mediterranean diet; metabolic syndrome;
   plant-based foods; polyphenols; polyunsaturated fatty acids
ID FATTY LIVER-DISEASE; CORONARY-HEART-DISEASE; BODY-MASS INDEX; ACTIVATED
   PROTEIN-KINASE; ENERGY SENSING NETWORK; HUMAN SKELETAL-MUSCLE;
   CARDIOVASCULAR-DISEASE; OXIDATIVE STRESS; ADIPOSE-TISSUE; SARCOPENIC
   OBESITY
AB The abnormal expansion of body fat paves the way for several metabolic abnormalities including overweight, obesity, and diabetes, which ultimately cluster under the umbrella of metabolic syndrome (MetS). Patients with MetS are at an increased risk of cardiovascular disease, morbidity, and mortality. The coexistence of distinct metabolic abnormalities is associated with the release of pro-inflammatory adipocytokines, as components of low-to-medium grade systemic inflammation and increased oxidative stress. Adopting healthy lifestyles, by using appropriate dietary regimens, contributes to the prevention and treatment of MetS. Metabolic abnormalities can influence the function and energetic capacity of mitochondria, as observed in many obesity-related cardio-metabolic disorders. There are preclinical studies both in cellular and animal models, as well as clinical studies, dealing with distinct nutrients of the Mediterranean diet (MD) and dysfunctional mitochondria in obesity and MetS. The term "Mitochondria nutrients" has been adopted in recent years, and it depicts the adequate nutrients to keep proper mitochondrial function. Different experimental models show that components of the MD, including polyphenols, plant-derived compounds, and polyunsaturated fatty acids, can improve mitochondrial metabolism, biogenesis, and antioxidant capacity. Such effects are valuable to counteract the mitochondrial dysfunction associated with obesity-related abnormalities and can represent the beneficial feature of polyphenols-enriched olive oil, vegetables, nuts, fish, and plant-based foods, as the main components of the MD. Thus, developing mitochondria-targeting nutrients and natural agents for MetS treatment and/or prevention is a logical strategy to decrease the burden of disease and medications at a later stage. In this comprehensive review, we discuss the effects of the MD and its bioactive components on improving mitochondrial structure and activity.
C1 [Khalil, Mohamad; Shanmugam, Harshitha; Abdallah, Hala; Britto, Jerlin Stephy John; Galerati, Ilaria; Portincasa, Piero] Univ Bari, Dept Biomed Sci & Human Oncol, Clin Med A Murri, Med Sch, Piazza Giulio Cesare 11, I-70124 Bari, Italy.
   [Khalil, Mohamad] Univ Bari Aldo Moro, Dept Soil Plant & Food Sci, Via Amendola 165-A, I-70126 Bari, Italy.
   [Gomez-Ambrosi, Javier; Fruhbeck, Gema] Clin Univ Navarra, Metab Res Lab, Pamplona 31008, Spain.
   [Gomez-Ambrosi, Javier; Fruhbeck, Gema] ISCIII, CIBER Fisiopatol Obesidad & Nutr CIBEROBN, Pamplona 28029, Spain.
   [Gomez-Ambrosi, Javier; Fruhbeck, Gema] Inst Invest Sanitaria Navarra IdiSNA, Obes & Adipobiol Grp, Pamplona 31008, Spain.
   [Fruhbeck, Gema] Clin Univ Navarra, Dept Endocrinol & Nutr, Pamplona 31008, Spain.
C3 Universita degli Studi di Bari Aldo Moro; Universita degli Studi di Bari
   Aldo Moro; University of Navarra; Instituto de Salud Carlos III; CIBER -
   Centro de Investigacion Biomedica en Red; CIBEROBN; University of
   Navarra
RP Portincasa, P (corresponding author), Univ Bari, Dept Biomed Sci & Human Oncol, Clin Med A Murri, Med Sch, Piazza Giulio Cesare 11, I-70124 Bari, Italy.
EM mohamad.khalil@uniba.it; harshitha.shanmugam@uniba.it;
   hala.abdallah@uniba.it; jerlin.johnbritto@uniba.it;
   ilariagalerati@live.it; jagomez@unay.es; gfruhbeck@unay.es;
   piero.portincasa@uniba.it
RI Shanmugam, Harshitha/LCE-0958-2024; Khalil, Mohamad/ISA-5550-2023;
   portincasa, piero/J-7245-2018; Gomez-Ambrosi, Javier/D-2984-2017
OI Fruhbeck, Gema/0000-0002-8305-7154; Gomez-Ambrosi,
   Javier/0000-0001-5601-1604; portincasa, piero/0000-0001-5359-1471
FU European Union's Horizon 2020 Research and Innovation program under the
   Marie Sklodowska-Curie Grant [722619, 734719]; Grant Regione Puglia [CUP
   H99C20000340002]; Grant EUROSEEDS Uniba-S56-By-Products Sustainable
   Recovery 4 Health (BSR-4H): University of Bari Aldo Moro, 2022
FX This paper has been partly supported by funding from the European
   Union's Horizon 2020 Research and Innovation program under the Marie
   Sklodowska-Curie Grant Agreement No. 722619 (FOIE GRAS), Grant Agreement
   No. 734719 (mtFOIE GRAS), Grant Regione Puglia, CUP H99C20000340002
   (Fever Apulia), and Grant EUROSEEDS Uniba-S56-By-Products Sustainable
   Recovery 4 Health (BSR-4H): University of Bari Aldo Moro, 2022.
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NR 278
TC 36
Z9 36
U1 3
U2 28
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD AUG
PY 2022
VL 14
IS 15
AR 3112
DI 10.3390/nu14153112
PG 31
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 3S9OS
UT WOS:000839917100001
PM 35956289
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Romero-García, T
   Landa-Galvan, HV
   Pavón, N
   Mercado-Morales, M
   Valdivia, HH
   Rueda, A
AF Romero-Garcia, Tatiana
   Landa-Galvan, Huguet, V
   Pavon, Natalia
   Mercado-Morales, Martha
   Valdivia, Hector H.
   Rueda, Angelica
TI Autonomous activation of CaMKII exacerbates diastolic calcium leak
   during beta-adrenergic stimulation in cardiomyocytes of metabolic
   syndrome rats
SO CELL CALCIUM
LA English
DT Article
DE Ca2+/calmodulin-dependent protein kinase type II; Diastolic Ca(2+)leak;
   Cardiac ryanodine receptor phosphorylation; beta-adrenergic stimulation;
   Metabolic syndrome; High sucrose diet
ID RYANODINE RECEPTOR PHOSPHORYLATION; CARDIAC SARCOPLASMIC-RETICULUM;
   KINASE-II; RYR2 PHOSPHORYLATION; OXIDATIVE STRESS; CA2+ SPARKS; HEART;
   DYSFUNCTION; RELEASE; CONTRIBUTES
AB Autonomous Ca2+/calmodulin-dependent protein kinase II (CaMKII) activation induces abnormal diastolic Ca2+ leak, which leads to triggered arrhythmias in a wide range of cardiovascular diseases, including diabetic cardiomyopathy. In hyperglycemia, Ca2+ handling alterations can be aggravated under stress conditions via the beta-adrenergic signaling pathway, which also involves CaMKII activation. However, little is known about intracellular Ca2+ handling disturbances under beta-adrenergic stimulation in cardiomyocytes of the prediabetic metabolic syndrome (MetS) model with obesity, and the participation of CaMKII in these alterations.
   MetS was induced in male Wistar rats by administering 30 % sucrose in drinking water for 16 weeks. Fluo 3-loaded MetS cardiomyocytes exhibited augmented diastolic Ca2+ leak (in the form of spontaneous Ca2+ waves) under basal conditions and that Ca2+ leakage was exacerbated by isoproterenol (ISO, 100 nM). At the molecular level, [H-3]-ryanodine binding and basal phosphorylation of cardiac ryanodine receptor (RyR2) at Ser2814, a CaMKII site, were increased in heart homogenates of MetS rats with no changes in RyR2 expression. These alterations were not further augmented by Isoproterenol. SERCA pump activity was augmented 48 % in MetS hearts before beta-adrenergic stimuli, which is associated to augmented PLN phosphorylation at T17, a target of CaMKII. In MetS hearts. CaMKII auto-phosphorylation (T287) was increased by 80 %. The augmented diastolic Ca2+ leak was prevented by CaMKII inhibition with AIP. In conclusion, CaMKII autonomous activation in cardiomyocytes of MetS rats with central obesity significantly contributes to abnormal diastolic Ca2+ leak, increasing the propensity for beta-adrenergic receptor-driven lethal arrhythmias.
C1 [Romero-Garcia, Tatiana; Landa-Galvan, Huguet, V; Mercado-Morales, Martha; Rueda, Angelica] IPN, Cinvestav, Ctr Invest & Estudios Avanzados IPN, Dept Biochem, Mexico City 07300, DF, Mexico.
   [Pavon, Natalia] Inst Nacl Cardiol Ignacio Chavez, Dept Pharmacol, Mexico City, DF, Mexico.
   [Valdivia, Hector H.] Univ Wisconsin, Sch Med & Publ Hlth, Dept Med, Div Cardiovasc Med, Madison, WI 53705 USA.
C3 CINVESTAV - Centro de Investigacion y de Estudios Avanzados del
   Instituto Politecnico Nacional; Instituto Politecnico Nacional - Mexico;
   National Institute of Cardiology - Mexico; University of Wisconsin
   System; University of Wisconsin Madison
RP Rueda, A (corresponding author), IPN, Cinvestav, Dept Biochem, Av IPN 2508, Mexico City 07360, DF, Mexico.
EM arueda@cinvestav.mx
RI Rueda, Angelica/G-4055-2012
OI Rueda, Angelica/0000-0001-8749-8494; Pavon, Natalia/0000-0002-8520-5077;
   Romero-Garcia, Tatiana/0000-0003-4316-2248; VALDIVIA,
   HECTOR/0000-0003-1231-6267
FU Fundacion Miguel Aleman A. C.; Fondo SEP-Cinvestav approved project
   [601410 FIDSC 2018/2]; Fondo SEP-Conacyt Ciencia Basica [A1-S-9082];
   PRODEP-SEP grant [28915/2018]; NIH [R01-HL055438, R01-HL134344]
FX This work was partially supported by Fundacion Miguel Aleman A. C., and
   Fondo SEP-Cinvestav approved project #601410 FIDSC 2018/2 to R, A; Fondo
   SEP-Conacyt Ciencia Basica A1-S-9082 to R, A; by a PRODEP-SEP grant to
   the Academic Group CINVESTAV-CA-10, ID 28915/2018 and by NIH grants
   R01-HL055438 and R01-HL134344 to V, HH. R, A was a COMEXUS-Fulbright
   Fellow to perform a research stay at Hector H. Valdivia laboratory
   (Center for Arrhythmia Research, University of Michigan Ann Arbor, MI,
   USA); R-G, T and L-G, H were CONACYT Ph.D. fellows.
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NR 61
TC 5
Z9 6
U1 0
U2 5
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0143-4160
EI 1532-1991
J9 CELL CALCIUM
JI Cell Calcium
PD NOV
PY 2020
VL 91
AR 102267
DI 10.1016/j.ceca.2020.102267
PG 13
WC Cell Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Physiology
GA SW8UO
UT WOS:000664790900014
PM 32920522
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Chis, BA
   Chis, AF
   Muresan, A
   Fodor, D
AF Chis, Bogdan Augustin
   Chis, Ana Florica
   Muresan, Adriana
   Fodor, Daniela
TI Q10 Coenzyme Supplementation can Improve Oxidative Stress Response to
   Exercise in Metabolic Syndrome in Rats
SO INTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCH
LA English
DT Article
DE Metabolic syndrome; Q10 coenzyme; malondialdehyde; thiol groups; chronic
   exercise
ID LIPID-PEROXIDATION; INSULIN-RESISTANCE; CARBOHYDRATE; DISEASE; MARKERS;
   PROTEIN; DIETS; Q(10)
AB Background: The metabolic syndrome leads to high morbidity and mortality. Almost all pathological states are associated with oxidative stress (OS) disorders. This study evaluates the effects of Coenzyme Q10 (CoQ10) supplementation on different lifestyles, in relation to serum and tissue OS parameters. Materials and methods: Twelve Wistar rat groups (10 rats/group) were equally divided in three types of diets: standard (St), high fat (HF), high sugar (HS); within each diet group there was one sedentary group with CoQ10 supplementation (100 mg/kg body weight), one sedentary without CoQ10, one trained group with CoQ10 and one trained group without CoQ10 supplementation. After 28 days blood samples were collected as follows: after 12 hours of fasting (TO), 1 hour postprandial (T1) and after 1 hour of exercise (T2) or sedentary postprandial time (T3). Thiol groups (SH) and malondialdehyde (MDA) were determined from serum and liver homogenate. Results: Significant changes were observed in fasting MDA for HF (p = 0.024 for training, 0.028 for CoQ10). Postprandial, OS status altered, with highest MDA in HF sedentary non-CoQ10 group (3.92 +/- 0.37 vs 2.67 +/- 0.41 nmol/ml in St trained CoQ10). At T2 the untrained and non-Coal 0 groups had the highest MDA levels (up to 22.3% vs T1, p < 0.001 in HF) as SH dropped (34.4% decrease vs T1, p < 0.001 in HF). At T3 high MDA levels were observed, correlated with low SH (Pearson r = -0.423 overall), irrespective of the CoQ10 supplementation. CoQ10 improved the liver OS status (MDA and SH decreased), but not the exercise, in all diets. Conclusions: CoQ10 supplementation accompanied by chronic exercise improved the OS serum profile, irrespective of the daily diet. CoQ10 lowered liver MDA and SH concentrations.
C1 [Chis, Bogdan Augustin; Fodor, Daniela] Iuliu Hatieganu Univ Med & Pharm, Dept Internal Med 2, Cluj Napoca, Romania.
   [Chis, Ana Florica] Iuliu Hatieganu Univ Med & Pharm, Dept Pulmonol, Cluj Napoca, Romania.
   [Muresan, Adriana] Iuliu Hatieganu Univ Med & Pharm, Physiol Dept, Cluj Napoca, Romania.
C3 Iuliu Hatieganu University of Medicine & Pharmacy; Iuliu Hatieganu
   University of Medicine & Pharmacy; Iuliu Hatieganu University of
   Medicine & Pharmacy
RP Chis, BA (corresponding author), Iuliu Hatieganu Univ Med & Pharm, Internal Med Dept 2, Cluj Cty Emergency Hosp, Clin 2-4 St, Cluj Napoca 400006, Romania.
EM bogdan_a_chis@yahoo.com
RI Chis, Bogdan/AAE-5898-2022; Chis, Ana/HJH-7780-2023
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NR 40
TC 5
Z9 5
U1 1
U2 5
PU VERLAG HANS HUBER
PI BERN 9
PA LANGGASS-STRASSE 76, CH-3000 BERN 9, SWITZERLAND
SN 0300-9831
EI 1664-2821
J9 INT J VITAM NUTR RES
JI Int. J. Vitam. Nutr. Res.
PD JAN
PY 2020
VL 90
IS 1-2
BP 33
EP 41
DI 10.1024/0300-9831/a000301
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA KH7XA
UT WOS:000510862200005
PM 30887903
DA 2025-06-11
ER

PT J
AU Cepelova, M
   Kruseova, J
   Luks, A
   Capek, V
   Cepela, P
   Potockova, J
   Kraml, P
AF Cepelova, M.
   Kruseova, J.
   Luks, A.
   Capek, V.
   Cepela, P.
   Potockova, J.
   Kraml, P.
TI Accelerated atherosclerosis, hyperlipoproteinemia and insulin resistance
   in long-term survivors of Hodgkin lymphoma during childhood and
   adolescence
SO NEOPLASMA
LA English
DT Article
DE Hodgkin lymphoma; long-term survivors; hyperlipoproteinemia; insulin
   resistance; metabolic syndrome; intima-media thickness
ID INTIMA-MEDIA THICKNESS; ACUTE LYMPHOBLASTIC-LEUKEMIA; YOUNG-ADULT
   SURVIVORS; METABOLIC SYNDROME; CARDIOVASCULAR-DISEASE; 5-YEAR SURVIVORS;
   SCIENTIFIC STATEMENT; CAROTID ULTRASOUND; DIABETES-MELLITUS; OXIDATIVE
   STRESS
AB Long-term survivors of Hodgkin lymphoma during childhood or adolescence (HL survivors) are at high risk of developing treatment-related late cardiovascular sequelae. In our study we evaluated the presence of modifiable cardiovascular risk factors (hypertension, hyperlipoproteinemia, hyperinsulinemia, obesity), endothelial and inflammatory markers (E-selectin, PAI-1, hs-CRP) and atherosclerotic changes in the common carotid arteries. Assessment was performed in 80 young adult Hodgkin lymphoma long-term survivors at more than 10 years after the potentially cardiovascular toxic anticancer treatment (median age at evaluation 34.7 years; range 24.1-40.9 years). The HL survivors were compared with 83 age- and gender-matched healthy volunteers. The HL survivors showed unfavorable lipid profiles compared to those of healthy controls: triglycerides (p=0.01), total cholesterol (p=0.0004), low density lipoprotein cholesterol (p=0.005). In HL survivors, we found a higher prevalence of hypertension (p=0.004) and insulin resistance - HOMA-IR (p=0.0002). Ultrasonographic examination of both common carotid arteries revealed a higher prevalence of atherosclerotic plaques (p=0.0009) and higher carotid intima-media thickness (p<0.0001) in HL survivors. Markers of oxidative stress (advanced oxidation protein products, oxidized low-density lipoprotein), inflammation (hs-CRP) and endothelial dysfunction (E-selectin, PAI-1) were also higher in HL survivors (p<0.0001, p=0.0002, p=0.0031, p=0.0087, p=0.004, respectively). Adult survivors of Hodgkin lymphoma during childhood and adolescence need closer follow-up with screening of metabolic syndrome components, unfavorable lifestyle factors and early management of these risk factors.
C1 [Cepelova, M.; Kruseova, J.; Luks, A.; Capek, V.] Charles Univ Prague, Med Fac 2, Dept Pediat Hematol & Oncol, Prague, Czech Republic.
   [Cepelova, M.; Kruseova, J.; Luks, A.; Capek, V.] Univ Hosp Motol, Prague, Czech Republic.
   [Cepela, P.; Potockova, J.; Kraml, P.] Charles Univ Prague, Med Fac 3, Internal Clin 2, Prague, Czech Republic.
   [Cepela, P.; Potockova, J.; Kraml, P.] Kralovske Vinohrady Univ Hosp, Prague, Czech Republic.
C3 Charles University Prague; Motol University Hospital; Charles University
   Prague; University Hospital Vinohrady
RP Cepelova, M (corresponding author), Charles Univ Prague, Med Fac 2, Dept Pediat Hematol & Oncol, Prague, Czech Republic.; Cepelova, M (corresponding author), Univ Hosp Motol, Prague, Czech Republic.
EM michaela.cepelova@fnmotol.cz
RI Luks, Ales/G-7201-2015; Cepelova, Michaela/AAM-7116-2021; Kruseova,
   Jarmila/AAS-1036-2021; Capek, Vaclav/D-8555-2016
OI Capek, Vaclav/0000-0002-8574-7001
FU Ministry of Health of the Czech Republic [NV15-30494A]
FX This study was supported by grant NV15-30494A from the Ministry of
   Health of the Czech Republic. The authors would like to thank the HL
   survivors and healthy volunteers for their kind cooperation in this
   study, Dirk Hasenclever, Institute for Medical Informatics, Statistics
   and Epidemiology - IMISE, Leipzig University, Germany, for valuable
   advice.
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NR 56
TC 11
Z9 11
U1 0
U2 6
PU AEPRESS SRO
PI BRATISLAVA
PA BAJZOVA 7, BRATISLAVA, 821 08, SLOVAKIA
SN 0028-2685
EI 1338-4317
J9 NEOPLASMA
JI Neoplasma
PY 2019
VL 66
IS 6
BP 978
EP 987
DI 10.4149/neo_2019_190115N45
PG 10
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA JR5EW
UT WOS:000499649200013
PM 31305124
OA Bronze
DA 2025-06-11
ER

PT J
AU van Tienhoven-Wind, LJN
   Gruppen, EG
   James, RW
   Bakker, SJL
   Gans, ROB
   Dullaart, RPF
AF van Tienhoven-Wind, Lynnda J. N.
   Gruppen, Eke G.
   James, Richard W.
   Bakker, Stephan J. L.
   Gans, Rijk O. B.
   Dullaart, Robin P. F.
TI Serum paraoxonase-1 activity is inversely related to free thyroxine in
   euthyroid subjects: The PREVEND Cohort Study
SO EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
LA English
DT Article
DE free thyroxine; high-density lipoproteins; metabolic syndrome;
   paraoxonase-1; thyroid function
ID LOW-DENSITY-LIPOPROTEIN; INTIMA-MEDIA THICKNESS; C-REACTIVE PROTEIN;
   OXIDATIVE STRESS; METABOLIC SYNDROME; THYROID-FUNCTION; ANTIOXIDATIVE
   FUNCTIONALITY; CARDIOVASCULAR-DISEASE; I ACTIVITY; HYPOTHYROIDISM
AB BackgroundLow-normal thyroid function within the euthyroid range has been suggested to enhance atherosclerosis susceptibility. Paraoxonase-1 (PON-1) may protect against atherosclerotic cardiovascular disease development by attenuating oxidative stress. We evaluated relationships of PON-1 with thyroid stimulating hormone (TSH), free T-4, free T-3, lipids and apolipoprotein (apo)A-I in euthyroid subjects, and assessed whether such relationships are modified in the context of the metabolic syndrome (MetS).
   Materials and methodsSerum PON-1 activity (arylesterase activity), TSH, free T-4, free T-3, lipids and apoA-I was measured in 2206 euthyroid subjects (aged 28-75years; 1138 men (age 4913years) and 1068 women (age 4612years), recruited from the general population (PREVEND cohort).
   ResultsIn age- and sex-adjusted analysis, PON-1 activity (divided into tertiles) was positively related to TSH (=-0.045, P=.036) and inversely to free T-4 (=-0.042, P=.050) but not to free T-3 (=-0.027, P=.20). PON-1 activity was positively related to total cholesterol, non-HDL cholesterol and triglycerides, as well as to HDL cholesterol and apoA-I (P<.01 to <.001). The inverse relationship of PON-1 activity with free T-4 remained present after adjustment for lipids and other potential confounders (=-0.066, P=.002), but the positive relationship with TSH lost significance (=0.034, P=.11). The inverse relationship of PON-1 activity with free T-4 was not different in subjects with vs without MetS (P=.94), nor modified by the presence of its individual components (P.22 for each).
   ConclusionsSerum PON-1 activity is inversely associated with free T-4 in euthyroid subjects, suggesting that low-normal thyroid function may affect PON-1 regulation.
C1 [van Tienhoven-Wind, Lynnda J. N.; Gruppen, Eke G.; Bakker, Stephan J. L.; Gans, Rijk O. B.; Dullaart, Robin P. F.] Univ Med Ctr Groningen, Dept Internal Med, Groningen, Netherlands.
   [van Tienhoven-Wind, Lynnda J. N.; Gruppen, Eke G.; Bakker, Stephan J. L.; Gans, Rijk O. B.; Dullaart, Robin P. F.] Univ Groningen, Groningen, Netherlands.
   [James, Richard W.] Univ Geneva, Fac Med, Dept Internal Med, Geneva, Switzerland.
C3 University of Groningen; University of Groningen; University of Geneva
RP van Tienhoven-Wind, LJN (corresponding author), Univ Med Ctr Groningen, Dept Nephrol AA53, Groningen, Netherlands.
EM L.J.N.van.Tienhoven-Wind@umcg.nl
RI ; Bakker, Stephan/J-4023-2015
OI Gans, Reinold/0000-0001-5481-2387; Bakker, Stephan/0000-0003-3356-6791
FU Dutch Kidney Foundation [E.033]; Dade Behring; Ausam; Roche; Abbott;
   Dutch Heart Foundation
FX The Dutch Kidney Foundation supported the infrastructure of the PREVEND
   program from 1997 to 2003 (Grant E.033). The Groningen University
   Medical Center supported the infrastructure from 2003 to 2006. Dade
   Behring, Ausam, Roche and Abbott, financed laboratory equipment and
   reagents by which various laboratory determinations could be performed.
   Richard W. James conducted the assays for paraoxonase-1 activity in
   PREVEND. The Dutch Heart Foundation supported studies on lipid
   metabolism (2001-2005).
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NR 60
TC 1
Z9 1
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0014-2972
EI 1365-2362
J9 EUR J CLIN INVEST
JI Eur. J. Clin. Invest.
PD JAN
PY 2018
VL 48
IS 1
AR e12860
DI 10.1111/eci.12860
PG 10
WC Medicine, General & Internal; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Research & Experimental Medicine
GA FR1ZO
UT WOS:000418866800006
PM 29171874
OA Green Published
DA 2025-06-11
ER

PT J
AU Rabie, EM
   Heeba, GH
   Abouzied, MM
   Khalifa, MMA
AF Rabie, Esraa M.
   Heeba, Gehan H.
   Abouzied, Mekky M.
   Khalifa, Mohamed M. A.
TI Comparative effects of Aliskiren and Telmisartan in high fructose
   diet-induced metabolic syndrome in rats
SO EUROPEAN JOURNAL OF PHARMACOLOGY
LA English
DT Article
DE Metabolic syndrome; Insulin resistance; Fructose; Telmisartan; Aliskiren
ID RENIN-ANGIOTENSIN SYSTEM; TYPE-1 RECEPTOR BLOCKER; FACTOR-KAPPA-B;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; NONALCOHOLIC STEATOHEPATITIS;
   ADIPOSE-TISSUE; DIABETIC-RATS; LIVER-INJURY; WEIGHT-GAIN
AB Fructose is a commonly used sweetener associated with diets that increase the prevalence of metabolic syndrome (MS). Inhibition of the Fenin-angiotensin system (RAS) has been consistently demonstrated to reduce MS. However, there has been 110 direct comparison among different pharmacological modes of inhibiting the RAS concerning their effects on MS. This study investigated the effect of aliskiren, a direct renin inhibitor, versus telmisailan, an angiotensin If-receptor blocked, in the treatment of fructose-induced MS in rats. MS was induced by high fructose (FRC) diet feeding for 12 weeks. Oral administrations of telmisartan (TEL, 5 mg/kg), aliskiren (ALS, 30 mg/kg) or vehicle were started in the last 4 weeks. Results showed that administration of either TEL or ALS with FRC diet equally ameliorated the metabolic parameters (glucose level, oral glucose tolerance test, insulin resistance and serum lipids profile), systolic blood pressure and oxidative stress markers (malondialdehyde, nitric oxide, reduced ! glutathione levels and catalase activity). Additionally, the effects of TEL and ALS were associated with a decrease in body composition index and attenuation of liver index, serum liver enzyme activities and hepatic expressions of inflammatory and fibrotic markers (tumor necrosis factor-a, nuclear factor kappaB and transforming growth factor-beta) with a significant increase in hepatic glucose transporter-2 and peroxisome proliferator-activated receptors-alpha and gamma expressions. The results suggested that, at indicated dosage, ALS has ameliorative effect equal to that of TEL against FRC-induced metabolic and hepatic disorders; implying that drugs which inhibit the RAS, by different mode of inhibition, profoundly affect fructose-induced MS in rats. (C) 2015 Elsevier B.V. All rights reserved.
C1 [Rabie, Esraa M.; Heeba, Gehan H.; Khalifa, Mohamed M. A.] Menia Univ, Fac Pharm, Dept Pharmacol & Toxicol, El Minia 61111, Egypt.
   [Abouzied, Mekky M.] Menia Univ, Fac Pharm, Dept Biochem, El Minia 61111, Egypt.
C3 Egyptian Knowledge Bank (EKB); Minia University; Egyptian Knowledge Bank
   (EKB); Minia University
RP Heeba, GH (corresponding author), Menia Univ, Fac Pharm, Dept Pharmacol & Toxicol, El Minia 61111, Egypt.
EM ghhh70@yahoo.com
RI Khalifa, Mohamed/HGE-8087-2022; Heeba, Gehan/H-7245-2019
OI Abouzied, mekky/0000-0001-5309-3552; Heeba, Gehan H./0000-0002-6907-4441
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NR 54
TC 28
Z9 28
U1 0
U2 16
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0014-2999
EI 1879-0712
J9 EUR J PHARMACOL
JI Eur. J. Pharmacol.
PD AUG 5
PY 2015
VL 760
BP 145
EP 153
DI 10.1016/j.ejphar.2015.04.019
PG 9
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA CJ7HB
UT WOS:000355664200018
PM 25917321
OA Bronze
DA 2025-06-11
ER

PT J
AU Najjar, S
   Pahlajani, S
   De Sanctis, V
   Stern, JNH
   Najjar, A
   Chong, D
AF Najjar, Souhel
   Pahlajani, Silky
   De Sanctis, Virginia
   Stern, Joel N. H.
   Najjar, Amanda
   Chong, Derek
TI Neurovascular Unit Dysfunction and Blood-Brain Barrier Hyperpermeability
   Contribute to Schizophrenia Neurobiology: A Theoretical integration of
   Clinical and experimental evidence
SO FRONTIERS IN PSYCHIATRY
LA English
DT Review
DE schizophrenia; blood-brain barrier; neurovascular unit; endothelial
   cell; neuroinflammation; oxidative stress; nitric oxide synthase;
   endothelial nitric oxide synthase
ID NITRIC-OXIDE SYNTHASE; ASTROCYTE-ENDOTHELIAL INTERACTIONS;
   CONVERTING-ENZYME-ACTIVITY; CELL-ADHESION MOLECULE-1; OXIDATIVE STRESS;
   METABOLIC SYNDROME; WHITE-MATTER; ATYPICAL ANTIPSYCHOTICS; UNMEDICATED
   PATIENTS; ONSET SCHIZOPHRENIA
AB Schizophrenia is a psychotic disorder characterized by delusions, hallucinations, negative symptoms, as well as behavioral and cognitive dysfunction. It is a pathoetiologically heterogeneous disorder involving complex interrelated mechanisms that include oxidative stress and neuroinflammation. Neurovascular endothelial dysfunction and blood- brain barrier (BBB) hyperpermeability are established mechanisms in neurological disorders with comorbid psychiatric symptoms such as epilepsy, traumatic brain injury, and Alzheimer's disease. Schizophrenia is frequently comorbid with medical conditions associated with peripheral vascular endothelial dysfunction, such as metabolic syndrome, cardiovascular disease, and diabetes mellitus. However, the existence and etiological relevance of neurovascular endothelial dysfunction and BBB hyperpermeability in schizophrenia are still not well recognized. Here, we review the growing clinical and experimental evidence, indicating that neurovascular endotheliopathy and BBB hyperpermeability occur in schizophrenia patients. We present a theoretical integration of human and animal data linking oxidative stress and neuroinflammation to neurovascular endotheliopathy and BBB breakdown in schizophrenia. These abnormalities may contribute to the cognitive and behavioral symptoms of schizophrenia via several mechanisms involving reduced cerebral perfusion and impaired homeostatic processes of cerebral microenvironment. Furthermore, BBB disruption can facilitate interactions between brain innate and peripheral adaptive immunity, thereby perpetuating harmful neuroimmune signals and toxic neuroinflammatory responses, which can also contribute to the symptoms of schizophrenia. Taken together, these findings support the "mild encephalitis" hypothesis of schizophrenia. If neurovascular abnormalities prove to be etiologically relevant to the neurobiology of schizophrenia, then targeting these abnormalities may represent a promising therapeutic strategy.
C1 [Najjar, Souhel; Stern, Joel N. H.; Chong, Derek] Hofstra Northwell Sch Med, Dept Neurol, New York, NY USA.
   [Najjar, Souhel; Pahlajani, Silky; De Sanctis, Virginia; Stern, Joel N. H.] Lenox Hill Hosp, Dept Neurol, Neuroinflammat Div, New York, NY 10021 USA.
   [Najjar, Amanda] Vanderbilt Univ, Peabody Coll, Dept Psychol & Human Dev, Nashville, TN 37203 USA.
C3 Northwell Health; Northwell Health; Vanderbilt University; Vanderbilt
   University Peabody College
RP Najjar, S (corresponding author), Hofstra Northwell Sch Med, Dept Neurol, New York, NY USA.; Najjar, S (corresponding author), Lenox Hill Hosp, Dept Neurol, Neuroinflammat Div, New York, NY 10021 USA.
EM mna1024231@aol.com
OI Stern, Joel N.H./0000-0002-1259-2256
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NR 103
TC 147
Z9 152
U1 1
U2 19
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-0640
J9 FRONT PSYCHIATRY
JI Front. Psychiatry
PD MAY 23
PY 2017
VL 8
AR 83
DI 10.3389/fpsyt.2017.00083
PG 11
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA EW2BN
UT WOS:000402301600001
PM 28588507
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Thompson, JA
   Webb, RC
AF Thompson, Jennifer A.
   Webb, R. Clinton
TI Potential role of Toll-like receptors in programming of vascular
   dysfunction
SO CLINICAL SCIENCE
LA English
DT Article
DE developmental programming; metabolic syndrome; oxidative stress;
   pro-inflammation; Toll-like receptor
ID INTRAUTERINE GROWTH RESTRICTION; INSULIN-RESISTANCE; OXIDATIVE STRESS;
   ADULT HYPERTENSION; BIRTH-WEIGHT; MOUSE MODEL; INNATE; INFLAMMATION;
   TOLL-LIKE-RECEPTOR-4; INHIBITION
AB The developmental origins of the metabolic syndrome have been established through the consistent observation that small-for-gestational age and large-for-gestational age fetuses have an increased risk for hypertension and related metabolic disorders later in life. These phenotypes have been reproduced in various species subjected to a range of intrauterine insults and ongoing research is directed towards understanding the underlying molecular mechanisms. Current evidence suggests that the creation of a pro-inflammatory and pro-oxidant intrauterine milieu is a common thread among prenatal factors that have an impact upon fetal size. Furthermore, studies demonstrate that a shift in fetal redox status consequent to environmental cues persists after birth and drives the progression of vascular dysfunction and hypertension in postnatal life. TLR (Toll-like receptor) signalling has emerged as a key link between inflammation and oxidative stress and a pathogenic contributor to hypertension, insulin resistance and obesity, in both human patients and animal models of disease. Thus TLR activation and dysregulation of its signalling components represent potential molecular underpinnings of programmed hypertension and related disorders in those subjected to suboptimal intrauterine conditions, yet their contributions to developmental programming remain unexplored. We propose that danger signals mobilized by the placenta or fetal tissues during complicated pregnancy activate the fetal innate immune system through TLRs and thereby potentiate the generation of ROS (reactive oxygen species) and orchestrate fetal adaptive responses, including changes in gene expression, which later translate to vascular dysfunction. Furthermore, we suggest that, after birth, continual activation of TLR signalling propagates vascular oxidative stress and thereby accelerates the advancement of hypertension and heart failure.
C1 [Thompson, Jennifer A.; Webb, R. Clinton] Georgia Regents Univ, MCG Dept Physiol, Augusta, GA 30912 USA.
C3 University System of Georgia; Augusta University
RP Thompson, JA (corresponding author), Georgia Regents Univ, MCG Dept Physiol, 1120 15th St, Augusta, GA 30912 USA.
EM jthompson2@gru.edu
OI Thompson, Jennifer/0000-0003-0421-3719
FU National Institutes of Health [DK-83685]; Society for Women's Health
   Research
FX Our own work was supported by the National Institutes of Health [grant
   number DK-83685] and the Society for Women's Health Research
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NR 50
TC 21
Z9 31
U1 0
U2 14
PU PORTLAND PRESS LTD
PI LONDON
PA CHARLES DARWIN HOUSE, 12 ROGER STREET, LONDON WC1N 2JU, ENGLAND
SN 0143-5221
EI 1470-8736
J9 CLIN SCI
JI Clin. Sci.
PD JUL
PY 2013
VL 125
IS 1-2
BP 19
EP 25
DI 10.1042/CS20120673
PG 7
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 154YE
UT WOS:000319711800002
PM 23485061
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Sakamuri, A
   Sakamuri, SSVP
   Kona, SR
   Jeyapal, S
   Ibrahim, A
AF Sakamuri, Anil
   Sakamuri, Siva S. V. P.
   Kona, Suryam Reddy
   Jeyapal, Sugeedha
   Ibrahim, Ahamed
TI Diets with low n-6:n-3 PUFA ratio protects rats from fructose-induced
   dyslipidemia and associated hepatic changes: Comparison between 18:3 n-3
   and long-chain n-3 PUFA
SO PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
LA English
DT Article
DE n-6:n-3 pufa ratio; High-fructose diet; Metabolic syndrome;
   Dyslipidemia; Hepatic tissue inflammation; Oxidative stress;
   Alpha-linolenic acid; Long-chain n-3 PUFA
ID POLYUNSATURATED FATTY-ACIDS; 11-BETA-HYDROXYSTEROID DEHYDROGENASE
   TYPE-1; INSULIN-RESISTANCE; METABOLIC SYNDROME; OXIDATIVE STRESS;
   PARTIAL REPLACEMENT; BETA-OXIDATION; LINOLEIC-ACID; LIVER; INFLAMMATION
AB In the present study, we investigated the impact of substituting alpha-linolenic acid (ALA) or long-chain n-3 PUFA (eicosapentaenoic acid and docosahexaenoic acid) for linoleic acid and hence decreasing n-6:n-3 PUFA ratio on high-fructose diet-induced hypertriglyceridemia and associated hepatic changes. Weanling male Wistar rats were divided into four groups and fed with starch-diet (n-6:n-3 PUFA ratio 215:1) and high-fructose diets with different n-6:n-3 PUFA ratio (215:1, 2:1 with ALA and 5:1 with long-chain n-3 PUFA) for twenty-four weeks. Substitution of linoleic acid with ALA (n-6:n-3 PUFA ratio of 2) or long-chain n-3 PUFA (n-6:n-3 PUFA ratio of 5) protected the rats from fructose-induced dyslipidemia, hepatic oxidative stress and corrected lipogenic and proinflammatory gene expression. Both ALA and long-chain n-3 PUFA supplementation also reversed the fructose-induced upregulation of 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1) gene, which is involved in the generation of active glucocorticoids in tissues. Although both ALA and LC n-3 PUFA prevented fructose-induced dyslipidemia to a similar extent, compared to ALA, LC n-3 PUFA is more effective in preventing hepatic oxidative stress and inflammation.
C1 [Sakamuri, Anil; Sakamuri, Siva S. V. P.; Kona, Suryam Reddy; Jeyapal, Sugeedha; Ibrahim, Ahamed] Natl Inst Nutr, Dept Lipid Chem, Hyderabad, India.
   [Sakamuri, Siva S. V. P.] Tulane Univ, Sch Med, Dept Pharmacol, New Orleans, LA 70112 USA.
C3 Indian Council of Medical Research (ICMR); ICMR - National Institute of
   Nutrition (NIN); Tulane University
RP Ibrahim, A (corresponding author), Natl Inst Nutr, Dept Lipid Chem, Hyderabad, India.
EM ahamed65@yahoo.co.in
OI Sakamuri, Siva Sankara Vara Prasad/0000-0003-3569-9985
FU Department of Biotechnology, Government of India
   [BT/PR6181/FNS/20/568/2012]; Council of Scientific and Industrial
   Research, Government of India
FX This study was supported by grants in aid (BT/PR6181/FNS/20/568/2012,
   25/02/2013) from the Department of Biotechnology, Government of India,
   to AI. AS was supported by a fellowship from the Council of Scientific
   and Industrial Research, Government of India.
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NR 74
TC 5
Z9 6
U1 0
U2 14
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0952-3278
EI 1532-2823
J9 PROSTAG LEUKOTR ESS
JI Prostaglandins Leukot. Essent. Fatty Acids
PD APR
PY 2020
VL 155
AR 102082
DI 10.1016/j.plefa.2020.102082
PG 11
WC Biochemistry & Molecular Biology; Cell Biology; Endocrinology &
   Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology; Endocrinology &
   Metabolism
GA LC4TS
UT WOS:000525319100005
PM 32169807
DA 2025-06-11
ER

PT J
AU Poudel, A
   Zhou, JY
   Mekala, N
   Welchko, R
   Rosca, MG
   Li, LX
AF Poudel, Anil
   Zhou, Joseph Yi
   Mekala, Naveen
   Welchko, Ryan
   Rosca, Mariana Georgeta
   Li, Lixin
TI Berberine hydrochloride protects against cytokine-induced inflammation
   through multiple pathways in undifferentiated C2C12 myoblast cells
SO CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
LA English
DT Article
DE berberine; cytokine; insulin resistance; inflammation
ID INDUCED INSULIN-RESISTANCE; KAPPA-B ACTIVATION; SKELETAL-MUSCLE;
   OXIDATIVE STRESS; KINASE; MECHANISM; DYSFUNCTION; EXPRESSION; INDUCTION;
   OBESITY
AB Obesity is associated with skeletal muscle insulin resistance and the development of metabolic syndrome. Undifferentiated skeletal muscle cells are sensitive to oxidative stress. Berberine hydrochloride (BBR) improves insulin resistance and exhibits anti-inflammatory properties. However, the underlying mechanism and the cell signaling pathways involved remain largely elusive. We therefore investigated the anti-inflammatory effects of BBR and the signaling pathways using skeletal C2C12 myoblast cells. Undifferentiated C2C12 myoblast cells were treated with interleukin-1 beta alone or in combination with tumor necrosis factor-alpha in the presence or absence of BBR. We found that BBR reduced the cytokine-induced expression of inducible nitric oxide synthase and stress-related kinases including p-38 mitogen-activated protein kinase, nuclear factor kappa B (NF-kappa B), and stress-activated protein kinases/Jun amino-terminal kinases (SAPK/JNK) in C2C12 myoblast cells. Furthermore, BBR reversed cytokine-mediated suppression of AMP-activated protein kinase (AMPK alpha), sirtuin-1 (SIRT-1), and PPAR-gamma coactivator-1 alpha (PGC-1 alpha). In addition, cytokine-induced reduction of mitochondrial marker proteins and function were rescued after BBR treatment. Catalase, an antioxidant enzyme, was elevated after BBR treatment. Our results demonstrate that BBR ameliorates cytokine-induced inflammation. The anti-inflammatory effect of BBR in skeletal progenitor cells is mediated through pathways including activation of the AMPK alpha-SIRT-1-PGC-1 alpha, inhibition of the mitogen-activated protein kinase 4 (MKK4)-SAPK/JNK-C-JUN, as well as protection of mitochondrial bioenergetics. BBR may be a potential medication for metabolic syndrome.
C1 [Poudel, Anil; Welchko, Ryan; Li, Lixin] Cent Michigan Univ, Phys Assistant Program, Coll Hlth Profess, Mt Pleasant, MI 48859 USA.
   [Zhou, Joseph Yi; Mekala, Naveen; Rosca, Mariana Georgeta] Cent Michigan Univ, Coll Med, Mt Pleasant, MI 48859 USA.
C3 Central Michigan University; Central Michigan University
RP Li, LX (corresponding author), Cent Michigan Univ, Phys Assistant Program, Coll Hlth Profess, Mt Pleasant, MI 48859 USA.
EM li6l@cmich.edu
RI LI, LIXIN/KFS-0074-2024; Rosca, Mariana/ABH-7847-2020; Mekala,
   Naveen/AGN-0107-2022
OI Rosca, Mariana/0000-0003-3605-9787
FU Central Michigan University
FX L.L. is supported by the faculty start-up fund from Central Michigan
   University. The authors thank Darren Story for editing of English
   grammar for the paper and Cassandra Ann Keinath for technical support.
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NR 53
TC 12
Z9 15
U1 1
U2 13
PU CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS
PI OTTAWA
PA 65 AURIGA DR, SUITE 203, OTTAWA, ON K2E 7W6, CANADA
SN 0008-4212
EI 1205-7541
J9 CAN J PHYSIOL PHARM
JI Can. J. Physiol. Pharmacol.
PD AUG
PY 2019
VL 97
IS 8
BP 699
EP 707
DI 10.1139/cjpp-2018-0653
PG 9
WC Pharmacology & Pharmacy; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Physiology
GA IL9OG
UT WOS:000477613400002
PM 31026403
DA 2025-06-11
ER

PT J
AU Dong, SF
   Yasui, N
   Negishi, H
   Kishimoto, A
   Sun, JN
   Ikeda, K
AF Dong, Shi-fen
   Yasui, Naomi
   Negishi, Hiroko
   Kishimoto, Aya
   Sun, Jian-ning
   Ikeda, Katsumi
TI Increased Oxidative Stress in Cultured 3T3-L1 Cells was Attenuated by
   Berberine Treatment
SO NATURAL PRODUCT COMMUNICATIONS
LA English
DT Article
DE Berberine; 3T3-L1 cells; Oxidative stress
ID METABOLIC SYNDROME; DIFFERENTIATION; EXPRESSION; ADIPOCYTE; OBESITY;
   INSULIN
AB The 3T3-L1 cell line is one of the most well-characterized and reliable models for studying adipocytes. Increased oxidative stress in accumulated fat was found in 3T3-L1 cells. Berberine, an isoquinoline alkaloid, could suppress fat deposition in 3T3-L1 cells; however, whether berberine suppresses increased oxidative stress is not well known. In this study, we observed the effect of berberine on increased oxidative stress in 3T3-L1 cells. 3T3-L1 cells were cultured and treated with berberine (5-20 mu M) from day 3 to day 8. We confirmed that berberine markedly inhibited fat accumulation and lipid droplets in 3T3-L1 adipocytes and decreased triglyceride content Berberine inhibited increased oxidative stress in 3T3-L1 cells by suppressing reactive oxygen species (ROS) production, and increased glutathione peroxidase (GPx) gene expression and GPx activity. Berberine also markedly reduced adipokines secreted by adipocytes, including leptin and resistin.
C1 [Dong, Shi-fen; Sun, Jian-ning] Beijing Univ Chinese Med, Sch Chinese Mat Med, Dept Pharmacol, Beijing 100029, Peoples R China.
   [Yasui, Naomi; Negishi, Hiroko; Kishimoto, Aya; Ikeda, Katsumi] Mukogawa Womens Univ, Sch Pharm & Pharmaceut Sci, Nishinomiya, Hyogo 6638179, Japan.
C3 Beijing University of Chinese Medicine; Mukogawa Women's University
RP Dong, SF (corresponding author), Beijing Univ Chinese Med, Sch Chinese Mat Med, Dept Pharmacol, Beijing 100029, Peoples R China.
EM ikeda@mukogawa-u.ac.jp
RI Dong, Shifen/AAS-9769-2021
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NR 14
TC 15
Z9 17
U1 0
U2 12
PU NATURAL PRODUCTS INC
PI WESTERVILLE
PA 7963 ANDERSON PARK LN, WESTERVILLE, OH 43081 USA
SN 1934-578X
EI 1555-9475
J9 NAT PROD COMMUN
JI Nat. Prod. Commun.
PD JUN
PY 2015
VL 10
IS 6
BP 895
EP 897
PG 3
WC Chemistry, Medicinal; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Food Science & Technology
GA CK9NB
UT WOS:000356565700024
PM 26197511
DA 2025-06-11
ER

PT J
AU Walker, L
   Smith, N
   Delon, C
AF Walker, Louise
   Smith, Natalie
   Delon, Christine
TI Weight loss, hypertension and mental well-being improvements during
   COVID-19 with a multicomponent health promotion programme on Zoom: a
   service evaluation in primary care
SO BMJ NUTRITION, PREVENTION & HEALTH
LA English
DT Article
DE weight management; blood pressure lowering; dietary patterns; mental
   health; metabolic syndrome
ID LOW-CARBOHYDRATE-DIET; MANAGEMENT; ADULTS; APPETITE; INSULIN; STRESS;
   IMPACT; SLEEP; TIME
AB BackgroundObesity is a risk factor for complications from SARS-CoV-2 infection, increasing the need for effective weight management measures in primary care. However, in the UK, COVID-19 restrictions have hampered primary care weight management referral and delivery, and COVID-19 related weight gain has been reported. The present study evaluated outcomes from a multicomponent weight loss and health promotion programme in UK primary care, delivered remotely due to COVID-19 restrictions.MethodPatients with obesity, type 2 diabetes or pre-diabetes attended six 90 min sessions over 10 weeks on Zoom. The dietary component comprised a low-carbohydrate 'real food' approach, augmented with education on physical activity, intermittent fasting, gut health, stress management, sleep and behaviour change. Anthropometric and cardiometabolic data were self-reported. Mental well-being was assessed with the Warwick Edinburgh Mental Wellbeing Scale. Subjective outcomes and participant feedback about the programme were collected with an anonymous online survey.ResultsTwenty participants completed the programme. Weight loss and improvements in body mass index, waist circumference, systolic and diastolic blood pressure and mental well-being achieved statistical and clinical significance. Mean weight loss (5.8 kg) represented a 6.5% weight loss. Participants' subjective outcomes included weight loss without hunger (67%) and increased confidence in their ability to improve health (83%). All participants reported the usage of Zoom to access the programme as acceptable with 83% reporting it worked well.ConclusionA multicomponent weight loss and health promotion programme with a low-carbohydrate dietary component, clinically and statistically significantly improved health outcomes including weight status, blood pressure and mental well-being in a group of primary care patients when delivered remotely. Further research is warranted.
C1 [Walker, Louise; Smith, Natalie] Bentley Village Surg, Farnham GU10 5LP, England.
RP Walker, L (corresponding author), Bentley Village Surg, Farnham GU10 5LP, England.
EM lou@louwalker.com
OI Delon, Christine/0000-0001-5163-1716
FU A31 Group Primary Care Network
FX The authors would like to thank the participating patients, and staff
   and partners of the A31 Group Primary Care Network. We are grateful to
   Dr Campbell Murdoch, Dr Jen Unwin and Dr David Unwin for reviewing
   drafts of the manuscript, and to Sam Feltham for his help throughout the
   project. Finally, our thanks go to the Public Health Collaboration
   ambassadors who facilitated the group sessions and online support
   groups.
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NR 66
TC 6
Z9 6
U1 0
U2 0
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
EI 2516-5542
J9 BMJ NUTR PREV HLTH
JI BMJ Nutr. Prev. Health
PD JUN
PY 2021
VL 4
IS 1
BP 102
EP 110
DI 10.1136/bmjnph-2020-000219
PG 9
WC Nutrition & Dietetics
WE Emerging Sources Citation Index (ESCI)
SC Nutrition & Dietetics
GA CH5Z1
UT WOS:001124388600032
PM 34308117
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Zheng, L
   Cui, CC
   Yue, SQ
   Yan, H
   Zhang, T
   Ding, M
   Sun, QC
   He, CY
   Ren, H
AF Zheng, Lan
   Cui, Cancan
   Yue, Siqi
   Yan, Han
   Zhang, Te
   Ding, Meng
   Sun, Qichao
   He, Chengyan
   Ren, Hui
TI Longitudinal association between triglyceride glucose index and
   depression progression in middle-aged and elder adults: A national
   retrospective cohort study
SO NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
LA English
DT Article
DE Triglyceride glucose index; Insulin resistance; Depression; Cohort study
ID INSULIN-RESISTANCE; CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME;
   ADIPOSE-TISSUE; RISK-FACTORS; POPULATION; PREVALENCE; OBESITY;
   ATHEROSCLEROSIS; OVERWEIGHT
AB Background and aims: Psychological symptoms are prevalent among individuals with non-communicable diseases, while the longitudinal association between triglyceride glucose (TyG) index, an indicator of metabolic health, and depression progression remains unclear yet. This study aims to investigate the association of baseline TyG index and depression progression in middle-aged and elder adults. Methods and results: This retrospective cohort study enrolled 8287 participants aged 45 years or above from national China Health and Retirement Longitudinal Study in visit 1 (2011-2012), which were biennially followed for depression score until visit 4 (2017-2018). Multivariateadjusted regression models were used to evaluate the association of baseline TyG index with the individual level change rate and slope of depression score. The mean age (+/- SD) of participants was 58.25 +/- 9.10 years, and 3806 (45.9%) were men. There was no significant difference of depression score at baseline across TyG quartile groups (P Z 0.228). Participants in the highest quartile of TyG index had a 0.124 (95% CI: 0.018-0.230) higher change rate of depression score, and a 0.127 (95% CI: 0.019-0.235) higher change slope, compared to those in the lowest. The observed associations were consistent in multiple sensitivity analyses, and stable in men, the elder, and overweight people. Conclusion: TyG index is positively associated with depression progression especially in men, the elder and overweight people, which provides new insights for the primary prevention of depression disorder. (c) 2022 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.
C1 [Zheng, Lan; Cui, Cancan; Yue, Siqi; He, Chengyan] Jilin Univ, China Japan Union Hosp, Dept Lab Med, Changchun, Peoples R China.
   [Zheng, Lan] Jilin Univ, Hosp Stomatol, Dept Lab Med, Changchun, Peoples R China.
   [Yan, Han] Jilin Univ, China Japan Union Hosp, Dept Endocrinol & Metab, Changchun, Peoples R China.
   [Zhang, Te] Jilin Univ, China Japan Union Hosp, Dept Anesthesiol, Changchun, Peoples R China.
   [Ding, Meng] Jilin Univ, China Japan Union Hosp, Endoscopy Ctr, Changchun, Peoples R China.
   [Sun, Qichao] Jilin Univ, China Japan Union Hosp, Imaging & Nucl Med, Changchun, Peoples R China.
   [Ren, Hui] Jilin Univ, China Japan Union Hosp, Dept Gen Surg, Changchun, Peoples R China.
   [He, Chengyan] Jilin Univ, China Japan Union Hosp, Dept Lab Med, Changchun 130000, Peoples R China.
   [Ren, Hui] Jilin Univ, China Japan Union Hosp, Dept Gen Surg, Changchun 130000, Peoples R China.
C3 Jilin University; Jilin University; Jilin University; Jilin University;
   Jilin University; Jilin University; Jilin University; Jilin University;
   Jilin University
RP He, CY (corresponding author), Jilin Univ, China Japan Union Hosp, Dept Lab Med, Changchun 130000, Peoples R China.; Ren, H (corresponding author), Jilin Univ, China Japan Union Hosp, Dept Gen Surg, Changchun 130000, Peoples R China.
EM lanzheng@jlu.edu.cn; cccui19@mails.jlu.edu.cn; yuesq21@mails.jlu.edu.cn;
   yanhan@jlu.edu.cn; zhangte19@mails.jlu.edu.cn; dingmeng@jlu.edu.cn;
   sunqc18@mails.jlu.edu.cn; lanzheng@jlu.edu.cn; hren@jlu.edu.cn
RI Cui, Cancan/HNC-4267-2023
FU National Institute on Aging (NIA); World Bank; National Natural Science
   Foundation of China
FX This current study uses data from the CHARLS dataset and Codebook. The
   development of the CHARLS was funded by the National Institute on Aging
   (NIA), World Bank and National Natural Science Foundation of China. We
   are grateful for the staff of CHARLS and all the participants.
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NR 56
TC 16
Z9 17
U1 10
U2 28
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 0939-4753
EI 1590-3729
J9 NUTR METAB CARDIOVAS
JI Nutr. Metab. Carbiovasc. Dis.
PD MAR
PY 2023
VL 33
IS 3
BP 507
EP 515
DI 10.1016/j.numecd.2022.11.015
EA FEB 2023
PG 9
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism; Nutrition
   & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism;
   Nutrition & Dietetics
GA G6LT7
UT WOS:000990257600001
PM 36642610
OA Bronze
DA 2025-06-11
ER

PT J
AU Dai, MY
   Zhang, YY
   Chen, Y
   Wang, L
   Tian, YH
AF Dai, Mengyao
   Zhang, Yuyang
   Chen, Yang
   Wang, Long
   Tian, Yanghua
TI The association between lipid accumulation products and depression in US
   adults: A cross-sectional study from NHANES 2005-2018
SO INTERNATIONAL JOURNAL OF PSYCHIATRY IN MEDICINE
LA English
DT Article
DE depression; insulin resistance; lipid accumulation product; National
   Health and Nutrition Examination Survey; patient health questionnaire-9
ID INSULIN-RESISTANCE; METABOLIC SYNDROME; ABDOMINAL OBESITY; DISORDERS;
   POPULATION; MECHANISMS; ADIPOSITY; INDEX
AB Objective To investigate the potential correlation between lipid accumulation products (LAP) and depression in adults in the United States.Methods We analyzed data from 13,051 participants from the NHANES 2005-2018 cycle. The LAP index was calculated using the waist circumference (WC) and serum triglyceride (TG) levels, which reflect lipid toxicity. Participants who scored >= 10 on the patient health questionnaire-9 (PHQ-9) were considered depressed. Multivariate logistic regression analyses were conducted to explore the association between the LAP index and depression. Furthermore, we conducted subgroup analysis to identify potentially sensitive populations. Smoothed curve fitting and generalized additive model (GAM) regression were performed to verify the association between the LAP index and depression.Results A total of 13,051 participants were eligible for analysis. After adjusting for all potential confounders, the risk of depression tended to increase with an increasing LAP index (odds ratio [OR]: 1.0011, 95% confidence interval [CI]: 1.0001, 1.0021). Compared to participants with LAP quartile 1, participants with LAP quartile 3 exhibited the highest risk of depression (OR: 1.43, 95%CI: 1.03, 1.99). Subgroup analysis demonstrated a strong association between the LAP index and depression in men (OR: 1.002, 95%CI: 1.001, 1.004) or those with hypertension (OR: 1.002, 95%CI: 1.000, 1.003). Additionally, smoothed curve fitting and GAM regression demonstrated a positive linear correlation between the LAP index and depression.Conclusions Our findings suggest that individuals with a higher LAP index may be at higher risk of depression, particularly men or those with hypertension. However, further studies are required to confirm these findings.
C1 [Dai, Mengyao; Tian, Yanghua] Anhui Med Univ, Affiliated Hosp 1, Dept Neurol, 218 Jixi Rd, Hefei 230031, Anhui, Peoples R China.
   [Zhang, Yuyang] Anhui Med Univ, Affiliated Hosp 1, Dept Urol, Hefei, Peoples R China.
   [Chen, Yang; Wang, Long] Anhui Mental Hlth Ctr, Dept Psychiat, Hefei, Peoples R China.
   [Chen, Yang; Wang, Long] Fourth Peoples Hosp Hefei, Dept Psychiat, Hefei, Peoples R China.
   [Chen, Yang; Wang, Long] Anhui Med Univ, Affiliated Psychol Hosp, Dept Psychiat, Hefei, Peoples R China.
   [Tian, Yanghua] Anhui Med Univ, Coll Mental Hlth & Psychol Sci, Hefei, Peoples R China.
   [Tian, Yanghua] Collaborat Innovat Ctr Neuropsychiat Disorders &, Hefei 230032, Peoples R China.
C3 Anhui Medical University; Anhui Medical University; Anhui Medical
   University; Anhui Medical University
RP Tian, YH (corresponding author), Anhui Med Univ, Affiliated Hosp 1, Dept Neurol, 218 Jixi Rd, Hefei 230031, Anhui, Peoples R China.
EM ayfytyh@126.com
FU National Natural Science Foundation of China [32071054]; Anhui
   Provincial Science Fund for Distinguished Young Scholars [1808085J23]
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: This work
   was supported by the National Natural Science Foundation of China (No.
   32071054) and Anhui Provincial Science Fund for Distinguished Young
   Scholars (1808085J23).
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NR 46
TC 0
Z9 0
U1 3
U2 8
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0091-2174
EI 1541-3527
J9 INT J PSYCHIAT MED
JI Int. J. Psychiatr. Med.
PD NOV
PY 2024
VL 59
IS 6
BP 685
EP 701
DI 10.1177/00912174241265559
EA JUL 2024
PG 17
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA H8Z9B
UT WOS:001275140000001
PM 39044344
DA 2025-06-11
ER

PT J
AU Heinonen, I
   Rinne, P
   Ruohonen, ST
   Ruohonen, S
   Ahotupa, M
   Savontaus, E
AF Heinonen, I.
   Rinne, P.
   Ruohonen, S. T.
   Ruohonen, S.
   Ahotupa, M.
   Savontaus, E.
TI The effects of equal caloric high fat and western diet on metabolic
   syndrome, oxidative stress and vascular endothelial function in mice
SO ACTA PHYSIOLOGICA
LA English
DT Article
DE adiposity; high fat and Western diets; metabolism; oxidative stress;
   vascular function
ID LIVER-DISEASE; INSULIN-RESISTANCE; WEIGHT-GAIN; DYSFUNCTION; OBESITY;
   INDEX; MECHANISMS; EXPRESSION; RECEPTOR; MODEL
AB Aim Nutrition contributes to increased adiposity, but it remains to be determined whether high fat rather than Western diet exacerbates the development of obesity and other characteristics of metabolic syndrome and vascular function. Methods We studied the effects of high fat (45% kcal) diet (HFD) and equal caloric Western diet (WD) high in fat, sucrose and cholesterol for 8weeks in male C57B1/6N mice. Results Mice fed with HFD and WD showed substantially higher body adiposity (body fat %) compared with control mice receiving low fat (10%) diet (LFD). However, total body weight was higher only in HFD mice compared with other groups. The amount of liver triglycerides, cholesterol and oxidative damage was higher in WD mice compared with mice on LFD. There were no significant differences in fasting blood glucose or serum insulin, serum or muscle triglycerides, glucose tolerance or systolic blood pressure between the groups, but serum free fatty acids were increased in HFD mice compared with LFD. Increased levels of tissue and serum diene conjugation as a marker of oxidative stress were evident especially in WD mice. The endothelium-dependent relaxations were significantly impaired in the small mesenteric arteries of HFD mice, but not in the aorta. Maximal relaxations correlated negatively with body adiposity in WD but not in HFD mice. Conclusions The major finding in the present study is that without changing body weight, Western diet induces marked whole-body oxidative stress and elevates body adiposity, which associates with the endothelial function of resistance arteries.
C1 [Heinonen, I.; Rinne, P.; Ruohonen, S. T.; Ruohonen, S.; Savontaus, E.] Univ Turku, Dept Pharmacol Drug Dev & Therapeut, FIN-20521 Turku, Finland.
   [Heinonen, I.; Rinne, P.; Ruohonen, S. T.; Ruohonen, S.; Savontaus, E.] Univ Turku, Turku Ctr Dis Modeling, FIN-20521 Turku, Finland.
   [Heinonen, I.] Univ Turku, Turku PET Ctr, FIN-20521 Turku, Finland.
   [Heinonen, I.; Ruohonen, S. T.; Ahotupa, M.] Turku Univ Hosp, FIN-20520 Turku, Finland.
   [Heinonen, I.] Univ Turku, Res Ctr Appl & Prevent Cardiovasc Med, FIN-20521 Turku, Finland.
   [Ahotupa, M.] Univ Turku, Dept Physiol, MCA Res Lab, FIN-20521 Turku, Finland.
   [Savontaus, E.] Turku Univ Hosp, Clin Pharmacol Unit, FIN-20520 Turku, Finland.
C3 University of Turku; University of Turku; University of Turku;
   University of Turku; University of Turku; University of Turku;
   University of Turku
RP Heinonen, I (corresponding author), Univ Turku, Turku PET Ctr, POB 52, FIN-20521 Turku, Finland.
EM ilkka.heinonen@utu.fi
RI Ruohonen, Saku/MFI-3214-2025; Rinne, Petteri/N-7099-2019
OI Savontaus, Eriika/0000-0003-3421-0367
FU Finnish Funding Agency for Technology and Innovation; Academy of Finland
FX The study was supported by a grant from the Finnish Funding Agency for
   Technology and Innovation and the Academy of Finland. Ms. Raija
   Kaartosalmi and Ms. Suvi Parkkali are acknowledged for the work and
   skilful technical assistance with the laboratory assays.
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NR 45
TC 61
Z9 70
U1 0
U2 24
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1748-1708
EI 1748-1716
J9 ACTA PHYSIOL
JI Acta Physiol.
PD JUL
PY 2014
VL 211
IS 3
BP 515
EP 527
DI 10.1111/apha.12253
PG 13
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA AJ4CA
UT WOS:000337616500008
PM 24621461
DA 2025-06-11
ER

PT J
AU Tabur, S
   Torun, AN
   Sabuncu, T
   Turan, MN
   Celik, H
   Ocak, AR
   Aksoy, N
AF Tabur, Suzan
   Torun, Ayse Nur
   Sabuncu, Tevfik
   Turan, Mehmet Nuri
   Celik, Hakim
   Ocak, Ali Riza
   Aksoy, Nurten
TI Non-diabetic metabolic syndrome and obesity do not affect serum
   paraoxonase and arylesterase activities but do affect oxidative stress
   and inflammation
SO EUROPEAN JOURNAL OF ENDOCRINOLOGY
LA English
DT Article
ID DENSITY-LIPOPROTEIN; AUTOMATED-METHOD; LIVER-DISEASE; ASSOCIATION
AB Objective: Paraoxonase-1 (PON-1), which has PON and arylesterase activities, is a high-density lipoprotein (HDL)-bound antioxidant enzyme that inhibits atherosclerosis. Diabetes has been shown to have an impact on oxidative stress. The effect of metabolic syndrome (MetS) on oxidative stress and PON-1 has been shown before, and PON-1 has been found to be related with accelerated atherogenesis. This study aimed to determine the oxidative state and PON and arylesterase activities in non-diabetic MetS and non-MetS obese patients.
   Design: Thirty obese patients (3 M and 27 F) without MetS, 40 non-diabetic obese patients (3 M and 37 F) with MetS, and 30 controls (2 M and 28 F) were enrolled.
   Methods: A 75 g glucose tolerance test was performed. PON-1, PON, arylesterase, total antioxidant status (TAS), high-sensitive C-reactive protein (hsCRP), and metabolic parameters were analyzed.
   Results: PON and arylesterase activities were similar between the groups, while TAS was low in both MetS and obese groups compared to controls (P<0.01 and P<0.05 respectively). CRP was higher in the MetS group compared with the obese and control groups (P<0.01 and P<0.001 respectively). In both the obese and MetS groups, CRP showed a positive correlation with body mass index (BMI). TAS was negatively correlated with BMI, waist circumference, triglyceride levels, and systolic and diastolic blood pressures (P<0.001).
   Conclusions: Oxidative stress is altered in non-diabetic MetS and non-MetS obese patients, but PON and arylesterase activities seem not to be affected. This result may be due to the absence of diabetes, the most severe form of altered carbohydrate metabolism.
C1 [Tabur, Suzan; Torun, Ayse Nur; Sabuncu, Tevfik] Harran Univ, Sch Med, Dept Endocrinol & Metab Dis, TR-63300 Sanliurfa, Turkey.
   [Turan, Mehmet Nuri] Harran Univ, Sch Med, Dept Internal Med, TR-63300 Sanliurfa, Turkey.
   [Celik, Hakim; Ocak, Ali Riza; Aksoy, Nurten] Harran Univ, Sch Med, Dept Clin Biochem, TR-63300 Sanliurfa, Turkey.
C3 Harran University; Harran University; Harran University
RP Torun, AN (corresponding author), Harran Univ, Sch Med, Dept Endocrinol & Metab Dis, TR-63300 Sanliurfa, Turkey.
EM aysenurizol@yahoo.com
RI celik, hakim/A-1789-2016; Sabuncu, Tevfik/ABF-5291-2020; Inan,
   Nurten/AAA-8197-2021
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NR 32
TC 45
Z9 45
U1 0
U2 4
PU BIOSCIENTIFICA LTD
PI BRISTOL
PA EURO HOUSE, 22 APEX COURT WOODLANDS, BRADLEY STOKE, BRISTOL BS32 4JT,
   ENGLAND
SN 0804-4643
EI 1479-683X
J9 EUR J ENDOCRINOL
JI Eur. J. Endocrinol.
PD MAR
PY 2010
VL 162
IS 3
BP 535
EP 541
DI 10.1530/EJE-09-0732
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 582QF
UT WOS:000276612100011
PM 20022940
DA 2025-06-11
ER

PT J
AU Tooke, JE
AF Tooke, JE
TI Possible pathophysiological mechanisms for diabetic angiopathy in type 2
   diabetes
SO JOURNAL OF DIABETES AND ITS COMPLICATIONS
LA English
DT Article
DE pathophysiological mechanisms; diabetic angiopathy; type 2 diabetes;
   oxidative stress; endothelial function; insulin resistance
ID INSULIN-RESISTANCE; MELLITUS; ENDOTHELIUM; NIDDM; DYSFUNCTION; RISK
AB The expression of large and small vessel disease in type 2 diabetes differs from that observed in type 1, with a higher prevalence of atherosclerosis and hypertension, maculopathy rather than proliferative retinopathy, and nephropathy of a more complex nature. Such differences are mirrored by differences in vascular pathophysiology with an early impairment of microvascular vasodilatory reserve being a prominent feature. The defect appears to be endothelium dependent and in conjunction with evidence of endothelium activation suggests that the endothelium plays a crucial role in the pathogenesis of vascular disease in type 2 diabetes and may even be an intrinsic feature or common antecedent of the insulin resistance syndrome. Several cellular mechanisms may be proposed linking insulin resistance and endothelial dysfunction including (i) abnormalities of common signal transduction mechanisms, (ii) alterations in cell membrane fluidity altering the expression and/or presentation of a wide range of receptors, or (iii) changes in oxidative stress. It is intuitively unlikely that the alteration of a single signal transduction mechanism could be a common cause, particularly as aspects of endothelial dysfunction implicate different mechanisms. Accordingly, changes in oxidative stress, either stemming from glucose-mediated increased free-radical generation and/or reduction of antioxidant capacity, are strong contender mechanisms. Not only may increased oxidative stress result in the quenching of nitric oxide, neutralizing its many protective functions, but it may also damage DNA, protein structure, and membrane properties. Elucidating the links between oxidative stress, endothelial function, and insulin resistance has important implications for the prevention of diabetic angiopathy and perhaps for the prevention of diabetes itself. (C) 2000 Elsevier Science Inc. All rights reserved.
C1 Univ Exeter, Sch Postgrad Med & Vasc Hlth Sci, Dept Diabet & Vasc Med, Exeter EX2 5AX, Devon, England.
C3 University of Exeter
RP Univ Exeter, Sch Postgrad Med & Vasc Hlth Sci, Dept Diabet & Vasc Med, Barrack Rd, Exeter EX2 5AX, Devon, England.
EM j.e.tooke@exeter.ac.uk
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NR 24
TC 73
Z9 82
U1 0
U2 5
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1056-8727
EI 1873-460X
J9 J DIABETES COMPLICAT
JI J. Diabetes Complications
PD JUL-AUG
PY 2000
VL 14
IS 4
BP 197
EP 200
DI 10.1016/S1056-8727(00)00083-0
PG 4
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 356XW
UT WOS:000089470300005
PM 11004428
DA 2025-06-11
ER

PT J
AU Quinn, LM
   Hadjiconstantinou, M
   Brady, EM
   Bodicoat, DH
   Henson, JJ
   Hall, AP
   Davies, MJ
AF Quinn, Lauren M.
   Hadjiconstantinou, Michelle
   Brady, Emer M.
   Bodicoat, Danielle H.
   Henson, Joseph J.
   Hall, Andrew P.
   Davies, Melanie J.
TI Chronotype and well-being in adults with established type 2 diabetes: A
   cross-sectional study
SO DIABETIC MEDICINE
LA English
DT Article
DE chronotype; depression; diabetes-related distress; self-compassion; type
   2 diabetes; well-being
ID SOCIAL JETLAG; DEPRESSION; DISTRESS; SLEEP; ASSOCIATIONS; POPULATION;
   PREVALENCE; MELLITUS
AB Aims 'Chronotype' describes an individual's sleep-wake schedule, and can be classified into morning, intermediate or evening types. Evening chronotype has been widely associated with increased cardiometabolic risk and mortality in people with type 2 diabetes. We explored associations between chronotype and markers of well-being in people with type 2 diabetes. Methods Participants of the 'Chronotype of Patients with Type 2 Diabetes and Effect on Glycaemic Control' (CODEC) observational study completed questionnaires to determine chronotype (Morningness-Eveningness Questionnaire, MEQ) and concurrent measures of well-being (Diabetes-related Distress scale, Patient Health Questionnaire-9 to measure depression, and Self-Compassion Scale), as a secondary endpoint of the study. Adjusted generalised linear models were used to compare well-being between chronotype subgroups in this cohort. Results Of the 808 individuals included in the CODEC study, from convenience sampling, 476 individuals completed the psychosocial questionnaire substudy. Of these, 67% (n = 321) were male, and 86% (n = 408) were white European. From the MEQ, 24% (n = 114) were morning chronotype, 24% (n = 113) were evening and 52% (n = 249) were intermediate chronotype. Diabetes-related distress was significantly higher in evening chronotypes (exponentiated adjusted coefficient = 1.18 (CI: 1.05-1.32)), compared to morning (p(adjusted) = 0.005) and intermediate chronotypes (p(adjusted) = 0.039). Similarly, depression was significantly higher in evening chronotypes (exponentiated adjusted coefficient = 1.84 (CI: 1.28-2.65)) compared to morning (p(adjusted) = 0.001) and intermediate chronotypes (p(adjusted) = 0.016). Discussion Evening chronotype in people with type 2 diabetes may be associated with higher levels of diabetes-related distress and depression. These findings warrant further investigation to establish causality and evidence-based interventions that negate the effects of evening chronotype in people with type 2 diabetes.
C1 [Quinn, Lauren M.; Brady, Emer M.; Henson, Joseph J.; Hall, Andrew P.; Davies, Melanie J.] Univ Hosp Leicester NHS Trust, Leicester Diabet Ctr, Leicester, Leics, England.
   [Hadjiconstantinou, Michelle; Davies, Melanie J.] Univ Leicester, Coll Life Sci, Diabet Res Ctr, Leicester, Leics, England.
C3 University of Leicester; University Hospitals of Leicester NHS Trust;
   University of Leicester
RP Hadjiconstantinou, M (corresponding author), Univ Leicester, Diabet Res Ctr, Leicester, Leics, England.
EM mh333@leicester.ac.uk
RI Davies, Melanie/AFA-4210-2022
OI Davies, Melanie/0000-0002-9987-9371; Henson, Joseph/0000-0002-3898-7053;
   Bodicoat, Danielle/0000-0002-2184-4865
FU Lifestyle theme of the National Institute of Health Research (NIHR)
   Leicester Biomedical Research Centre (BRC)
FX The CODEC study was supported by the Lifestyle theme of the National
   Institute of Health Research (NIHR) Leicester Biomedical Research Centre
   (BRC).
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NR 30
TC 8
Z9 8
U1 2
U2 11
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0742-3071
EI 1464-5491
J9 DIABETIC MED
JI Diabetic Med.
PD MAR
PY 2022
VL 39
IS 3
AR e14690
DI 10.1111/dme.14690
EA SEP 2021
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA YY5TT
UT WOS:000700949100001
PM 34529279
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Mokhtari-Ardekani, A
   Fayyazishishavan, E
   Akhavanfar, R
   Abbasalizad-Farhangi, M
AF Mokhtari-Ardekani, Abnoos
   Fayyazishishavan, Ehsan
   Akhavanfar, Roozbeh
   Abbasalizad-Farhangi, Mahdieh
TI Circulating Advanced Oxidation Protein Products (AOPPs) increases the
   risk of metabolic syndrome among adults: A systematic review and
   meta-analysis
SO INTERNATIONAL JOURNAL OF DIABETES IN DEVELOPING COUNTRIES
LA English
DT Review
DE Advanced oxidation protein products; Obesity; Adult population;
   Metabolic syndrome
ID GLYCATION END-PRODUCTS; STRESS MARKERS; INFLAMMATION; ASSOCIATION;
   BIOMARKERS; OBESITY; HEALTH
AB BackgroundSeveral studies have highlighted the possible role of advanced oxidation protein products (AOPPs) in promotion of metabolic syndrome (MetS). However, due to inconsistencies in this field, we aimed to quantitatively summarize the results of studies that evaluated the association between AOPPs, with MetS indices among adult population.MethodsIn a systematic search from PubMed, Embase, and Scopus electronic databases until 15 August 2022 without language restriction, a total of 1225 articles were obtained. Finally, after duplicate removal of 632 articles and removing of 537 articles according to title/abstract, seven article was included in final meta-analysis. These articles all had observational design, were performed in adults aged more than 18 years old, and evaluated the association between circulating AOPPs and MetS.ResultsIn our meta-analysis, circulating AOPPs was 17.51 mu mol/L higher in individuals with MetS versus individuals without MetS (WMD: 17.512; CI: 12.084, 22.939; p = 0.001). Gender, age, and sample size were recognized as possible heterogeneity sources in subgrouping and meta-regression. No evidence of publication bias was reported.ConclusionAccording to the results of the current meta-analysis, higher circulating AOPPs concentrations might be associated with MetS risk among adults. Further longitudinal studies are needed to better identify the causal associations between these variables.
C1 [Mokhtari-Ardekani, Abnoos] Kerman Univ Med Sci, Inst Basic & Clin Physiol Sci & Physiol, Endocrinol & Metab Res Ctr, Res Ctr, Kerman, Iran.
   [Fayyazishishavan, Ehsan] Univ Texas Hlth Sci Ctr Houston UTHealth, Sch Publ Hlth, Dept Biostat & Data Sci, Houston, TX 77030 USA.
   [Akhavanfar, Roozbeh] Isfahan Univ Med Sci, Sch Med, Esfahan, Iran.
   [Abbasalizad-Farhangi, Mahdieh] Tabriz Univ Med Sci, Tabriz Hlth Serv Management Res Ctr, Attar Nishabouri St, Tabriz 5166614711, Iran.
C3 Kerman University of Medical Sciences; University of Texas System;
   University of Texas Health Science Center Houston; University of Texas
   School Public Health; Isfahan University of Medical Sciences; Tabriz
   University of Medical Science
RP Abbasalizad-Farhangi, M (corresponding author), Tabriz Univ Med Sci, Tabriz Hlth Serv Management Res Ctr, Attar Nishabouri St, Tabriz 5166614711, Iran.
EM abbasalizad_m@yahoo.com
RI Farhangi, Mahdieh/AAC-6758-2019; Fayyazishishavan, Ehsan/GRY-2545-2022
OI Fayyazishishavan, Ehsan/0000-0002-9548-6028
FU Research Undersecretary of Tabriz University of Medical Sciences [71887]
FX AcknowledgementsThe work was supported by a grant from Research
   Undersecretary of Tabriz University of Medical Sciences (Grant number:
   71887).
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NR 39
TC 0
Z9 0
U1 1
U2 9
PU SPRINGER INDIA
PI NEW DELHI
PA 7TH FLOOR, VIJAYA BUILDING, 17, BARAKHAMBA ROAD, NEW DELHI, 110 001,
   INDIA
SN 0973-3930
EI 1998-3832
J9 INT J DIABETES DEV C
JI Int. Diabetes Dev. Ctries.
PD DEC
PY 2023
VL 43
IS 6
BP 847
EP 855
DI 10.1007/s13410-023-01178-4
EA MAR 2023
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA U7TH6
UT WOS:000959322200001
DA 2025-06-11
ER

PT J
AU Wang, XL
   Zhang, L
   Youker, K
   Zhang, MX
   Wang, J
   LeMaire, SA
   Coselli, JS
   Shen, YH
AF Wang, Xing Li
   Zhang, Lin
   Youker, Keith
   Zhang, Ming-Xiang
   Wang, Jian
   LeMaire, Scott A.
   Coselli, Joseph S.
   Shen, Ying H.
TI Free fatty acids inhibit insulin signaling-stimulated endothelial nitric
   oxide synthase activation through upregulating PTEN or inhibiting Akt
   kinase
SO DIABETES
LA English
DT Article
ID RECEPTOR SUBSTRATE-1; SKELETAL-MUSCLE; RISK-FACTOR; IKK-BETA; KAPPA-B;
   RESISTANCE; PHOSPHORYLATION; OBESITY; P38; PATHWAY
AB In metabolic syndrome, a systemic deregulation of the insulin pathway leads to a combined deregulation of insulin-regulated metabolism and cardiovascular functions. Free fatty acids (FFAs), which are increased in metabolic syndrome, inhibit insulin signaling and induce metabolic insulin resistance. This study was designed to examine FFAs' effects on vascular insulin signaling and endothelial nitric oxide (NO) synthase (eNOS) activation in endothelial cells. We showed that FFAs inhibited insulin signaling and eNOS activation through different mechanisms. While linoleic acid inhibited Akt-mediated eNOS phosphorylation, palmitic acid appeared to affect the upstream signaling. Upregulation of PTEN (phosphatase and tensin homolog deleted on chromosome 10) activity and transcription by palmitic acid mediated the inhibitory effects on insulin signaling. We further found that activated stress signaling p38, but not Jun NH2-terminal kinase, was involved in PTEN upregulation. The p38 target transcriptional factor activating transcription factor (ATF)-2 bound to the PTEN promoter, which was increased by palmitic acid treatment. In summary, both palmitic acid and linoleic acid exert inhibitory effect on insulin signaling and eNOS activation in endothelial cells. Palmitic acid inhibits insulin signaling by promoting PTEN activity and its transcription through p38 and its downstream transcription factor ATF-2. Our findings suggest that FFA-mediated inhibition of vascular insulin signaling and eNOS activation may contribute to cardiovascular diseases in metabolic syndrome.
C1 Baylor Coll Med, Michael E DeBakey Dept Surg, Houston, TX 77030 USA.
C3 Baylor College of Medicine
RP Shen, YH (corresponding author), Baylor Coll Med, Michael E DeBakey Dept Surg, MS NAB 2010,1 Baylor Plaza, Houston, TX 77030 USA.
EM xlwang@bcm.edu; hyshen@bcm.edu
RI wang, xingli/MHR-1399-2025; shen, ying/HHS-5635-2022
OI LeMaire, Scott/0000-0002-8736-4266; Youker, Keith/0000-0003-2535-7973
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NR 50
TC 187
Z9 223
U1 0
U2 9
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0012-1797
EI 1939-327X
J9 DIABETES
JI Diabetes
PD AUG
PY 2006
VL 55
IS 8
BP 2301
EP 2310
DI 10.2337/db05-1574
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 069SK
UT WOS:000239468300017
PM 16873694
OA hybrid
DA 2025-06-11
ER

PT J
AU Kravchenko, LS
   Appelhans, OL
   Poliakov, AE
   Borysiuk, IY
   Ivanova, YI
   Neskoromna, NV
   Rosumenko, MV
AF Kravchenko, L. S.
   Appelhans, O. L.
   Poliakov, A. E.
   Borysiuk, I. Yu.
   Ivanova, Y. I.
   Neskoromna, N. V.
   Rosumenko, M. V.
TI QUERCETIN EFFECTIVENESS IN THE COMPLEX HYPOLIPIDEMIC THERAPY OF PATIENTS
   WITH NONALCOHOLIC FATTY LIVER DISEASE WITH METABOLIC SYNDROME
SO WORLD OF MEDICINE AND BIOLOGY
LA English
DT Article
DE metabolic syndrome; nonalcoholic fatty liver disease; hypolipidemic
   therapy; quercetin; inflammation
AB 86 patients with metabolic syndrome and comorbid nonalcoholic fatty liver disease were carried out general clinical and laboratory-instrumental examinations. After registration of the initial data, the patients were divided into 2 groups: 41 patients with the use of rosuvastatin were added quercetin 40 mg 3 times a day for 3 months to the basic therapy (group 1). The basic therapy with rosuvastatin only was carried out in 45 patients (group 2). After the treatment on the 90th day, positive changes in lipid metabolism were registered in all the patients. The group 2 patients had a decrease in the level of low-density lipoproteins by 21.2 % (p<0.05), an increase in high-density lipoproteins by 43.3 % (p<0.05). The liver transaminase activity was lower by 15.0 %, concentration of proinflammatory interleukin-6 and cytokeratin-18 - by 10.0 % (p>0.05). In patients of the group 1 the level of low-density lipoproteins decreased by 39.5 % (p<0.05), the triglycerides - twice, activity of transaminase - by 30.0 % (p<he high-density lipoproteins level increased by 72.0 % (p<0.05). Interleukins and cytokeratin-18 concentration reliably decreased by 23.0 % (p<0.05) (p=0.001). It was found that the comorbid course of the nonalcoholic fatty liver disease is accompanied by an increase in the oxidative stress intensity, which is determined by increased level in the blood of the end products of lipid peroxidation - malondialdehyde - on average 3.8 times (p<0.05). The use of quercetin in the complex therapy of the nonalcoholic fatty liver disease contributes to a reliable reduction in the oxidative stress intensity, an increase in the antioxidant protection activity (superoxide dismutase), the consequence of which is a significant reduction in the hepatocytes apoptosis process (decrease in cytokeratine-18 level 1.27 times as much).
C1 [Kravchenko, L. S.; Appelhans, O. L.; Poliakov, A. E.; Borysiuk, I. Yu.; Ivanova, Y. I.; Neskoromna, N. V.; Rosumenko, M. V.] Odessa Natl Med Univ, Odessa, Ukraine.
C3 Odessa National Medical University
RP Kravchenko, LS (corresponding author), Odessa Natl Med Univ, Odessa, Ukraine.
EM lyudmila.kravchenko.52@gmail.com
RI Borysiuk, Iryna/AAV-8038-2021; Appel'hans, Olena/HTO-4206-2023
OI Appel'hans, Olena/0000-0002-2344-6502
FU  [0121U00263]
FX The study is a fragment of the research project "Comorbid conditions in
   patients with metabolic syndrome: familial hypercholesterolemia, fatty
   hepatosis, periodontopathies (pathogenesis, diagnosis, correction)",
   state registration number 0121U00263
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NR 15
TC 1
Z9 1
U1 0
U2 1
PU SCIENTIFIC SOC ANATOMISTS HISTOLOGISTS & EMBRYOLOGISTS UKRAINE
PI POLTAVA
PA VUL SHEVCHENKA 23, POLTAVA, 36024, UKRAINE
SN 2079-8334
J9 WORLD MED BIOL
JI World Med. Biol.
PY 2022
VL 81
IS 3
BP 76
EP 82
DI 10.26724/2079-8334-2022-3-81-76-82
PG 7
WC Medicine, Research & Experimental
WE Emerging Sources Citation Index (ESCI)
SC Research & Experimental Medicine
GA J9XU2
UT WOS:001013090600015
DA 2025-06-11
ER

PT J
AU Fariña, JP
   García, ME
   Alzamendi, A
   Giovambattista, A
   Marra, CA
   Spinedi, E
   Gagliardino, JJ
AF Pablo Farina, Juan
   Elisa Garcia, Maria
   Alzamendi, Ana
   Giovambattista, Andres
   Alberto Marra, Carlos
   Spinedi, Eduardo
   Jose Gagliardino, Juan
TI Antioxidant treatment prevents the development of fructose-induced
   abdominal adipose tissue dysfunction
SO CLINICAL SCIENCE
LA English
DT Article
DE abdominal adipocyte; adipokine; fructose-rich diet; insulin signalling;
   lipid metabolism; metabolic syndrome
ID SUGAR-SWEETENED BEVERAGES; NADPH OXIDASE ACTIVATION; SUCROSE-RICH DIET;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; METABOLIC-SYNDROME;
   GLUCOSE-METABOLISM; PANCREATIC-ISLETS; NAD(P)H OXIDASE; FEMALE RATS
AB In the present study, we tested the effect of OS (oxidative stress) inhibition in rats fed on an FRD [fructose-rich diet; 10% (w/v) in drinking water] for 3 weeks. Normal adult male rats received a standard CD (commercial diet) or an FRD without or with an inhibitor of NADPH oxidase, APO (apocynin; 5 mM in drinking water; CD-APO and FRD-APO). We thereafter measured plasma OS and metabolic-endocrine markers, AAT (abdominal adipose tissue) mass and cell size, FA (fatty acid) composition (content and release), OS status, LEP (leptin) and IRS (insulin receptor substrate)-1/IRS-2 mRNAs, ROS (reactive oxygen species) production, NADPH oxidase activity and LEP release by isolated AAT adipocytes. FRD-fed rats had larger AAT mass without changes in body weight, and higher plasma levels of TAG (triacylglycerol), FAs, TBARS (thiobarbituric acid-reactive substance) and LEP Although no significant changes in glucose and insulin plasma levels were observed in these animals, their HOMA-IR (homoeostasis model assessment of insulin resistance) values were significantly higher than those of CD. The AAT from FRD-fed rats had larger adipocytes, higher saturated FA content, higher NADPH oxidase activity, greater ROS production, a distorted FA content/release pattern, lower insulin sensitivity together with higher and lower mRNA content of LEP and IRS-1-/2 respectively, and released a larger amount of LEP The development of all the clinical, OS, metabolic, endocrine and molecular changes induced by the FRD were significantly prevented by APO co-administration. The fact that APO treatment prevented both changes in NADPH oxidase activity and the development of all the FRD-induced AAT dysfunctions in normal rats strongly suggests that OS plays an important role in the FRD-induced MS (metabolic syndrome) phenotype.
C1 [Pablo Farina, Juan; Elisa Garcia, Maria; Jose Gagliardino, Juan] Natl Univ La Plata, Sch Med, PAHO WHO Collaborating Ctr Diabet, UNLP CONICET LA PLATA,CENEXA, La Plata, Buenos Aires, Argentina.
   [Alzamendi, Ana; Giovambattista, Andres; Spinedi, Eduardo] CONICET LA PLATA, CICPBA, IMBICE, Neuroendocrine Unit, La Plata, Buenos Aires, Argentina.
   [Alberto Marra, Carlos] Natl Univ La Plata, Sch Med, INIBIOLP, UNLP CONICET LA PLATA, La Plata, Buenos Aires, Argentina.
C3 Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET);
   National University of La Plata; Consejo Nacional de Investigaciones
   Cientificas y Tecnicas (CONICET); National University of La Plata;
   Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET)
RP Gagliardino, JJ (corresponding author), Natl Univ La Plata, Sch Med, PAHO WHO Collaborating Ctr Diabet, UNLP CONICET LA PLATA,CENEXA, La Plata, Buenos Aires, Argentina.
EM direccion@cenexa.org
RI Spinedi, Eduardo/F-2455-2016
OI Alzamendi, Ana/0000-0003-4126-1103
FU Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET)
   [PIP2009-0704, PIP2009-5020, 2010-0697]; Fondation pour la Recherche en
   Endocrinologie, Diabetologie et Metabolisme (FPREDM) [2011/2012]; Fondo
   para la Investigacion Cientifica y Tecnologica (FONCyT) [PICT 2001-1051]
FX This study was supported by the Consejo Nacional de Investigaciones
   Cientificas y Tecnicas (CONICET) [grant numbers PIP2009-0704 (to E.S.),
   PIP2009-5020 (to J.J.G.) and 2010-0697 (to C.A.M.)], the Fondation pour
   la Recherche en Endocrinologie, Diabetologie et Metabolisme (FPREDM)
   [grant number 2011/2012 (to E.S.)] and the Fondo para la Investigacion
   Cientifica y Tecnologica (FONCyT) [grant number PICT 2001-1051 (to
   E.S)].
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NR 52
TC 31
Z9 32
U1 0
U2 20
PU PORTLAND PRESS LTD
PI LONDON
PA THIRD FLOOR, EAGLE HOUSE, 16 PROCTER STREET, LONDON WC1V 6 NX, ENGLAND
SN 0143-5221
J9 CLIN SCI
JI Clin. Sci.
PD JUL
PY 2013
VL 125
IS 1-2
BP 87
EP 97
DI 10.1042/CS20120470
PG 11
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 154YE
UT WOS:000319711800011
PM 23384123
OA Green Published
DA 2025-06-11
ER

PT J
AU Olgar, Y
   Tuncay, E
   Billur, D
   Turan, B
AF Olgar, Yusuf
   Tuncay, Erkan
   Billur, Deniz
   Turan, Belma
TI Bimodal Effects of P2Y12 Antagonism on Matrix
   Metalloproteinase-Associated Contractile Dysfunction in
   Insulin-Resistant Mammalian Heart
SO BIOLOGICAL TRACE ELEMENT RESEARCH
LA English
DT Article
DE Metabolic syndrome; Heart dysfunction; Ticagrelor; Matrix
   metalloproteinase; Zinc
ID METABOLIC-SYNDROME; EXTRACELLULAR-MATRIX; DIETARY SELENIUM; VITAMIN-E;
   TICAGRELOR; STRESS; GLUCOSE; ZINC
AB The matrix metalloproteinases (MMPs) contribute to matrix remodeling in diabetes via tissue degradation; however, their contributions can be different depending on the pathology. For instance, MMPs are elevated in acute stress hyperglycemia, whereas they can be degraded in chronic hyperglycemia. Since studies emphasize the possible cardioprotective effect of ticagrelor (Tica) beyond its antiplatelet action, we aimed to examine whether Tica treatment can reverse the depressed heart function of metabolic syndrome (MetS) rats via affecting the expression levels of MMPs. Tica treatment of high-carbohydrate-induced MetS rats could not affect significantly the depressed contractile activity of Langendorff-perfused heart preparations. On the other hand, the Tica treatment provided a significant recovery in the reduced relaxation activity of the aortic preparations from the same animals. Histological examination of the hearts demonstrated marked damages in Mets rats, such as increases in the number of foamy cells and accumulation of collagen fiber and increases in the elastic lamellar irregularity of tunica media, while Tica treatment provided a slight improvement in the structure of left ventricle tissue. We also could not obtain a significant reverse in the high cytosolic labile Zn2+ ([Zn2+](i)) with the treatment of cardiomyocytes with Tica. Furthermore, Tica treatment of MetS rats could not significantly reverse the degraded protein levels of MMP-2 and MMP-9 in the heart, as well. Overall, we demonstrated that Tica treatment of MetS rats has no significant benefits on the depressed heart function, although provide a significant beneficial impact on vascular relaxation. This action of Tica may be through its lack of action on both MMP degradation and high [Zn2+](i), which can further precipitate in cleavage of extracellular matrix in the heart.
C1 [Olgar, Yusuf; Tuncay, Erkan; Turan, Belma] Ankara Univ, Fac Med, Dept Biophys, Ankara, Turkey.
   [Billur, Deniz] Ankara Univ, Fac Med, Dept Histol & Embryol, Ankara, Turkey.
   [Turan, Belma] Lokman Hekim Univ, Fac Med, Dept Biophys, Ankara, Turkey.
C3 Ankara University; Ankara University; Lokman Hekim University
RP Turan, B (corresponding author), Ankara Univ, Fac Med, Dept Biophys, Ankara, Turkey.; Turan, B (corresponding author), Lokman Hekim Univ, Fac Med, Dept Biophys, Ankara, Turkey.
EM belma.turan@medicine.ankara.edu.tr
RI TURAN, Belma/AAG-8084-2020; olğar, yusuf/I-8960-2016; Billur,
   Deniz/N-4933-2018; TUNCAY, ERKAN/AAG-8065-2020
FU Scientific and Technological Research Council of Turkey [SGAB-216S979]
FX This work was supported by grants (No. SGAB-216S979) from The Scientific
   and Technological Research Council of Turkey.
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NR 53
TC 1
Z9 1
U1 0
U2 10
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0163-4984
EI 1559-0720
J9 BIOL TRACE ELEM RES
JI Biol. Trace Elem. Res.
PD MAY
PY 2022
VL 200
IS 5
BP 2195
EP 2204
DI 10.1007/s12011-021-02816-w
EA JUL 2021
PG 10
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 0Q2UC
UT WOS:000673885100001
PM 34268701
DA 2025-06-11
ER

PT J
AU Onaolapo, AY
   Adebisi, EO
   Adeleye, AE
   Olofinnade, AT
   Onaolapo, OJ
AF Onaolapo, Adejoke Yetunde
   Adebisi, Ebenezer Oladimeji
   Adeleye, Adegbayi Emmanuel
   Olofinnade, Anthony Tope
   Onaolapo, Olakunle James
TI Dietary Melatonin Protects Against Behavioural, Metabolic, Oxidative,
   and Organ Morphological Changes in Mice that are Fed High-Fat,
   High-Sugar Diet
SO ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS
LA English
DT Article
DE Brain; dysmetabolism; diet; neurobehaviour; melatonergic; glucose
ID BODY-WEIGHT GAIN; LIPID-PEROXIDATION; INSULIN-RESISTANCE; DAYTIME
   MELATONIN; STRESS; BRAIN; MODEL; PATHOPHYSIOLOGY; PINEALECTOMY;
   ADIPONECTIN
AB Background: Metabolic syndrome is a complex pattern of disorders that occur jointly and is associated with an increased risk of cardiovascular and cerebrovascular disease. Therefore the need for more-efficient options of treatment has become imperative.
   Objective: This study examined the effect of dietary-melatonin in the management of behavioural, metabolic, antioxidant, and organ changes due to high-fat/high-sugar (HFHS) diet-induced metabolic syndrome in mice.
   Methods: Mice were randomly assigned into five groups of ten animals each. Groups were normal control [fed standard diet (SD)], HFHS control, and 3 groups of mclatonin incorporated into HFHS at 2.5, 5, and 10 mg/kg of feed. Mice were fed for seven weeks, and body weight was assessed weekly. Open-field behaviours, radial-arm, and Y-maze spatial memory were scored at the end of the experimental period. Twenty-four hours after the last behavioural test, blood was taken for estimation of blood glucose levels after an overnight fast. Animals were then euthanised, and blood was taken for estimation of plasma insulin, leptin, and adiponectin levels, and serum lipid profile. The liver, kidneys, and brain were excised and processed for general histology, while homogenates of the liver and whole brain were used to assess oxidative stress parameters.
   Results: Results showed that dietary melatonin (compared to HFHS diet) was associated with a decrease in body weight, food intake, and novelty-induced behaviours; and an increase in spatial-working memory scores. A decrease in glucose, insulin, leptin, and malondialdehyde levels; and an increase in adiponectin levels and superoxide dismutase activity were also observed. Histomorphological/histomorphometric examination revealed evidence of organ injury with HFHS diet, and varying degrees of amelioration with melatonin-supplemented diet.
   Conclusion: In conclusion, dietary melatonin supplementation may have beneficial effects in the management of the metabolic syndrome.
C1 [Onaolapo, Adejoke Yetunde] Ladoke Akintola Univ Technol, Dept Anat, Behav Neurosci & Neurobiol Unit, Ogbomosho, Oyo State, Nigeria.
   [Onaolapo, Adejoke Yetunde; Adebisi, Ebenezer Oladimeji; Adeleye, Adegbayi Emmanuel] Ladoke Akintola Univ Technol, Dept Anat, Ogbomosho, Oyo State, Nigeria.
   [Olofinnade, Anthony Tope] Lagos State Univ, Coll Med, Fac Basic Clin Sci, Dept Pharmacol Therapeut & Toxicol, Ikeja, Lagos State, Nigeria.
   [Onaolapo, Olakunle James] Ladoke Akintola Univ Technol, Behav Neurosci & Neuropharmacol Unit, Pharmacol & Therapeut, Osogbo, Osun State, Nigeria.
C3 Lagos State University
RP Onaolapo, OJ (corresponding author), Ladoke Akintola Univ Technol, Behav Neurosci & Neuropharmacol Unit, Dept Behav Neurosci & Neuropharmacol Unit, Pharmacol & Therapeut,Fac Basic Med Sci, PMB 4400, Osogbo, Osun State, Nigeria.
EM olakunleonaolapo@yahoo.co.uk
RI Adebisi, Ebenezer/HRC-6393-2023; Onaolapo, Adejoke/HRC-4273-2023
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NR 60
TC 9
Z9 15
U1 0
U2 7
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1871-5303
EI 2212-3873
J9 ENDOCR METAB IMMUNE
JI Endocr. Metab. Immune Disord.-Drug Targets
PY 2020
VL 20
IS 4
BP 570
EP 583
DI 10.2174/1871530319666191009161228
PG 14
WC Endocrinology & Metabolism; Immunology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Immunology; Pharmacology & Pharmacy
GA LR3SG
UT WOS:000535612500008
PM 32138638
DA 2025-06-11
ER

PT J
AU Garg, S
   Mehndiratta, M
   Kar, R
   Malik, P
AF Garg, Seema
   Mehndiratta, Mohit
   Kar, Rajarshi
   Malik, Pranav
TI Interrelationship between nuclear factor-erythroid-2-related factor 2,
   NADPH quinone oxidoreductase and lipoprotein-associated phospholipase A2
   expression in young patients of metabolic syndrome
SO INTERNATIONAL JOURNAL OF DIABETES IN DEVELOPING COUNTRIES
LA English
DT Article
DE Metabolic syndrome; Lipoprotein-associated phospholipase A2; Nuclear
   factor E2-related factor 2; NAD(P)H quinone oxidoreductase 1
ID ABDOMINAL OBESITY; CELLULAR DEFENSE; NRF2; PATHWAY; ACTIVATION; RISK;
   A(2); DISEASE
AB Metabolic syndrome (MS) is associated with inflammation and oxidative stress (OS). Keap1/Nrf2/ARE is a cytoprotective pathway induced by OS and inflammation. This study aims to evaluate the expression of nuclear factor-erythroid-2-related factor 2 (Nrf2) and its downstream target gene NADPH quinone oxidoreductase-1 (NQO-1) in MS. Since lipoprotein-associated phospholipase A2(LpPLA2) is an important inflammatory marker believed to have a role in complications of MS, the association of its expression with that of Nrf2 and NQO-1 was also studied. Medical students (n=26) were categorised in two groups according to NCEP ATP III criteria with WHO criteria for obesity for South Asian region: patients of MS (n=13) and controls (n=13). mRNA expression of Nrf2, NQO-1 and LpPLA2 genes was evaluated by qPCR in blood using specific primers. Fold change was calculated by 2(-cT) method keeping -actin as internal control. Expression of NQO-1 and LpPLA2 was found to be higher in MS. However, Nrf2 expression was low in patients who had hypertriglyceridemia when compared with patients with normal triglyceride levels. A significant correlation was observed in expression of LpPLA2, with Nrf2 and NQO-1. Our data suggests that there may be compensatory activation of antioxidant defence mechanism in young patients of MS. Further evidence is provided by higher expression of LpPLA2 and its correlation with Nrf2 and NQO-1 in MS which suggests that inflammatory stress may induce expression of genes of cytoprotective pathways. Additionally, this study, for the first time, indicates that Nrf2 may have some role in regulating triglyceride (TG) concentration.
C1 [Garg, Seema; Mehndiratta, Mohit; Kar, Rajarshi] Univ Delhi, Univ Coll Med Sci, Dept Biochem, Delhi 110095, India.
   [Garg, Seema; Mehndiratta, Mohit; Kar, Rajarshi; Malik, Pranav] Univ Delhi, GTB Hosp, Delhi 110095, India.
   [Malik, Pranav] Univ Delhi, Univ Coll Med Sci, Delhi, India.
C3 University of Delhi; University College of Medical Sciences; University
   of Delhi; University College of Medical Sciences; University of Delhi;
   University College of Medical Sciences
RP Garg, S (corresponding author), Univ Delhi, Univ Coll Med Sci, Dept Biochem, Delhi 110095, India.; Garg, S (corresponding author), Univ Delhi, GTB Hosp, Delhi 110095, India.
EM seegarg@yahoo.com
FU Indian Council of Medical Research, New Delhi [2014-04698]
FX The study was conducted under the Short Term Studentship program
   (reference ID: 2014-04698) of Indian Council of Medical Research, New
   Delhi.
CR [Anonymous], 2000, ASIA PACIFIC PERSPEC
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NR 34
TC 0
Z9 0
U1 0
U2 4
PU SPRINGER INDIA
PI NEW DELHI
PA 7TH FLOOR, VIJAYA BUILDING, 17, BARAKHAMBA ROAD, NEW DELHI, 110 001,
   INDIA
SN 0973-3930
EI 1998-3832
J9 INT J DIABETES DEV C
JI Int. Diabetes Dev. Ctries.
PD JAN
PY 2019
VL 39
IS 1
BP 74
EP 81
DI 10.1007/s13410-018-0653-y
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA HQ8CO
UT WOS:000462651700012
DA 2025-06-11
ER

PT J
AU Meegaswatte, H
   Speer, K
   Mckune, AJ
   Naumovski, N
AF Meegaswatte, Harshini
   Speer, Kathryn
   Mckune, Andrew J.
   Naumovski, Nenad
TI Functional Foods and Nutraceuticals for the Management of Cardiovascular
   Disease Risk in Postmenopausal Women
SO REVIEWS IN CARDIOVASCULAR MEDICINE
LA English
DT Review
DE cardiovascular disease; menopause; postmenopausal women; metabolic
   syndrome; vascular health; functional foods; nutraceuticals
ID VASCULAR ENDOTHELIAL FUNCTION; N-ACETYLCYSTEINE; OXIDATIVE STRESS;
   L-THEANINE; ARTERIAL STIFFNESS; BODY-COMPOSITION; INSULIN SENSITIVITY;
   METABOLIC SYNDROME; DOUBLE-BLIND; PHYTOESTROGEN SUPPLEMENTATION
AB Cardiovascular disease (CVD) is a leading cause of death in women and risk of development is greatly increased following menopause. Menopause occurs over several years and is associated with hormonal changes, including a reduction in estradiol and an increase in follicle-stimulating hormone. This hormonal shift may result in an increased risk of developing abdominal adiposity, insulin resistance, dyslipidemia, vascular dysfunction, hypertension, type 2 diabetes mellitus (T2DM), metabolic dysfunction-associated fatty liver disease (MAFLD), and metabolic syndrome (MetS). Furthermore, with the onset of menopause, there is an increase in oxidative stress that is associated with impaired vascular function, inflammation, and thrombosis, further increasing the risk of CVD development. Despite the harmful consequences of the menopause transition being well known, women in premenopausal, perimenopausal, and postmenopausal stages are unlikely to be enrolled in research studies. Therefore, investigations on the prevention and treatment of cardiovascular and metabolic disease in middle-aged women are still relatively limited. Whilst lifestyle interventions are associated with reduced CVD risk in this population sample, the evidence still remains inconclusive. Therefore, it is important to explore the effectiveness of early intervention and potential therapeutic approaches to maintain cellular redox balance, preserve endothelium, and reduce inflammation. Glycine, N-acetylcysteine, and L-theanine are amino acids with potential antioxidant and anti-inflammatory activity and are identified as therapeutic interventions in the management of age-related and metabolic diseases. The benefits of the intake of these amino acids for improving factors associated with cardiovascular health are discussed in this review. Future studies using these amino acids are warranted to investigate their effect on maintaining the vascular health and cardiovascular outcomes of postmenopausal women.
C1 [Meegaswatte, Harshini; Speer, Kathryn; Mckune, Andrew J.; Naumovski, Nenad] Univ Canberra, Fac Hlth, Canberra, ACT 2617, Australia.
   [Meegaswatte, Harshini; Speer, Kathryn; Mckune, Andrew J.; Naumovski, Nenad] Univ Canberra, Funct Foods & Nutr Res FFNR Lab, Canberra, ACT 2617, Australia.
   [Meegaswatte, Harshini; Speer, Kathryn; Mckune, Andrew J.; Naumovski, Nenad] Univ Canberra, Univ Canberra Res Inst Sport & Exercise UCRISE, Canberra, ACT 2617, Australia.
   [Mckune, Andrew J.] Univ KwaZulu Natal, Sch Hlth Sci, Discipline Biokinet Exercise & Leisure Sci, ZA-4041 Durban, South Africa.
   [Naumovski, Nenad] Harokopio Univ, Sch Hlth Sci & Educ, Dept Nutr & Dietet, Athens 17676, Greece.
C3 University of Canberra; University of Canberra; University of Canberra;
   University of Kwazulu Natal; Harokopio University Athens
RP Naumovski, N (corresponding author), Univ Canberra, Fac Hlth, Canberra, ACT 2617, Australia.; Naumovski, N (corresponding author), Univ Canberra, Funct Foods & Nutr Res FFNR Lab, Canberra, ACT 2617, Australia.; Naumovski, N (corresponding author), Univ Canberra, Univ Canberra Res Inst Sport & Exercise UCRISE, Canberra, ACT 2617, Australia.; Naumovski, N (corresponding author), Harokopio Univ, Sch Hlth Sci & Educ, Dept Nutr & Dietet, Athens 17676, Greece.
EM nenad.naumovski@canberra.edu.au
RI McKune, Andrew/AAM-3086-2020; Naumovski, Nenad/O-5617-2015
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NR 153
TC 1
Z9 1
U1 4
U2 4
PU IMR PRESS
PI ROBINSON
PA 112 ROBINSON RD, ROBINSON, SINGAPORE
SN 1530-6550
EI 2153-8174
J9 REV CARDIOVASC MED
JI Rev. Cardiovasc. Med.
PD DEC 25
PY 2024
VL 25
IS 12
AR 460
DI 10.31083/j.rcm2512460
PG 15
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA Q6Y7N
UT WOS:001386114000001
PM 39742223
OA gold
DA 2025-06-11
ER

PT J
AU Georgoulis, M
   Kontogianni, MD
   Kechribari, I
   Tenta, R
   Fragopoulou, E
   Lamprou, K
   Perraki, E
   Vagiakis, E
   Yiannakouris, N
AF Georgoulis, Michael
   Kontogianni, Meropi D.
   Kechribari, Ioanna
   Tenta, Roxane
   Fragopoulou, Elizabeth
   Lamprou, Kallirroi
   Perraki, Eleni
   Vagiakis, Emmanouil
   Yiannakouris, Nikos
TI Associations between serum vitamin D status and the cardiometabolic
   profile of patients with obstructive sleep apnea
SO HORMONES-INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM
LA English
DT Article
DE Sleep apnea; 25-Hydroxyvitamin D; Vitamin D deficiency; Metabolic
   syndrome; Obesity; Insulin resistance; Inflammation; Oxidative stress
ID METABOLIC SYNDROME; D SUPPLEMENTATION; D DEFICIENCY; ADULTS; PREVALENCE;
   ACCURACY; GLUCOSE; PLASMA
AB Purpose Obstructive sleep apnea (OSA) and the metabolic syndrome (MetS) frequently coexist. Low serum vitamin D has been positively associated with OSA presence and severity; however, data on its link to cardiometabolic features in patients with OSA remain scarce. We aimed to assess serum 25-hydroxyvitamin D [25(OH)D] and explore its association with cardiometabolic parameters in OSA.
   Methods This was a cross-sectional study among 262 patients (49 +/- 9 years old, 73% men) with polysomnography-diagnosed OSA. Participants were evaluated in terms of anthropometric indices, lifestyle habits, blood pressure, biochemical, plasma inflammatory and urinary oxidative stress markers, and the presence of MetS. Serum 25(OH)D was assessed by chemiluminescence, and vitamin D deficiency (VDD) was defined as 25(OH)D < 20 ng/mL.
   Results Median (1(st), 3(rd) quartile) serum 25(OH)D levels were 17.7 (13.4, 22.9) ng/mL and 63% of participants had VDD. Serum 25(OH)D correlated negatively with body mass index (BMI), homeostasis model of assessment of insulin resistance (HOMA-IR), total cholesterol, low-density lipoprotein cholesterol, triglycerides, high-sensitivity C-reactive protein (hsCRP), and urinary oxidized guanine species (oxG), and positively with high-density lipoprotein cholesterol (all P < 0.050). In logistic regression analysis, serum 25(OH)D was associated with lower odds of MetS [odds ratio (95% confidence interval): 0.94 (0.90-0.98)], after adjustment for age, sex, season of blood sampling, Mediterranean diet score, physical activity, smoking, apnea-hypopnea index, HOMA-IR, hsCRP, and oxG. In the same multivariate model, VDD was associated with similar to two fold greater odds of MetS [2.39 (1.15, 4.97)].
   Conclusion VDD is highly prevalent and is associated with a detrimental cardiometabolic profile among patients with OSA.
C1 [Georgoulis, Michael; Kontogianni, Meropi D.; Kechribari, Ioanna; Tenta, Roxane; Fragopoulou, Elizabeth; Yiannakouris, Nikos] Harokopio Univ Athens, Sch Hlth Sci & Educ, Dept Nutr & Dietet, 70 El Venizelou Str, Athens 17676, Greece.
   [Lamprou, Kallirroi; Perraki, Eleni; Vagiakis, Emmanouil] Natl & Kapodistrian Univ Athens, Evangelismos Gen Hosp, Ctr Sleep Disorders, Dept Crit Care & Pulm Serv 1,Med Sch, Athens 10676, Greece.
C3 Harokopio University Athens; National & Kapodistrian University of
   Athens; Evangelismos Hospital
RP Yiannakouris, N (corresponding author), Harokopio Univ Athens, Sch Hlth Sci & Educ, Dept Nutr & Dietet, 70 El Venizelou Str, Athens 17676, Greece.
EM nyiannak@hua.gr
RI Kontogianni, Meropi/AAN-6530-2021; YIANNAKOURIS, NIKOS/AAL-7123-2021;
   Tenta, Roxane/AAM-9669-2021; Georgoulis, Michael/AAO-2167-2021
OI Yiannakouris, Nikos/0000-0003-3269-4919; Georgoulis,
   Michael/0000-0003-4619-2100
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NR 55
TC 6
Z9 6
U1 0
U2 6
PU SPRINGER INT PUBL AG
PI CHAM
PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND
SN 1109-3099
EI 2520-8721
J9 HORM-INT J ENDOCRINO
JI Horm.-Int. J. Endocrinol. Metab.
PD SEP
PY 2023
VL 22
IS 3
BP 477
EP 490
DI 10.1007/s42000-023-00456-4
EA JUN 2023
PG 14
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA HY2Q3
UT WOS:001007770500001
PM 37322405
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Mitjavila, MT
   Fandos, M
   Salas-Salvadó, J
   Covas, MI
   Borrego, S
   Estruch, R
   Lamuela-Raventós, R
   Corella, D
   Martínez-Gonzalez, MA
   Sánchez, JM
   Bulló, M
   Fitó, M
   Tormos, C
   Cerdá, C
   Casillas, R
   Moreno, JJ
   Iradi, A
   Zaragoza, C
   Chaves, J
   Sáez, GT
AF Teresa Mitjavila, Maria
   Fandos, Marta
   Salas-Salvado, Jordi
   Covas, Maria-Isabel
   Borrego, Silvia
   Estruch, Ramon
   Lamuela-Raventos, Rosa
   Corella, Dolores
   Angel Martinez-Gonzalez, Miguel
   Sanchez, Julia M.
   Bullo, Monica
   Fito, Montserrat
   Tormos, Carmen
   Cerda, Concha
   Casillas, Rosario
   Jose Moreno, Juan
   Iradi, Antonio
   Zaragoza, Cristobal
   Chaves, Javier
   Saez, Guillermo T.
CA PREDIMED Study Investigators
TI The Mediterranean diet improves the systemic lipid and DNA oxidative
   damage in metabolic syndrome individuals. A randomized, controlled,
   trial
SO CLINICAL NUTRITION
LA English
DT Article
DE Mediterranean diet; Oxidative stress; Metabolic syndrome; DNA damage;
   F2-isoprostanes; PREDIMED
ID OLIVE OILS; PHENOLIC-COMPOUNDS; OXIDIZED LDL; STRESS; METAANALYSIS;
   PREVALENCE; NUTRITION; ADHERENCE; HUMANS; PLASMA
AB Background Ea aims: Metabolic syndrome (MetS), in which a non-classic feature is an increase in systemic oxidative biomarkers, presents a high risk of diabetes and cardiovascular disease (CVD). Adherence to the Mediterranean Diet (MedDiet) is associated with a reduced risk of MetS. However, the effect of the MedDiet on biomarkers for oxidative damage has not been assessed in MetS individuals. We have investigated the effect of the MedDiet on systemic oxidative biomarkers in MetS individuals.
   Methods: Randomized, controlled, parallel clinical trial in which 110 female With MetS, aged 55-80, were recruited into a large trial (PREDIMED Study) to test the efficacy of the traditional MedDiet on the primary prevention of CVD. Participants were assigned to a low-fat diet or two traditional MedDiets (MedDiet + virgin olive oil or MedDiet + nuts). Both MedDiet group participants received nutritional education and either free extra virgin olive oil for all the family (1 L/week), or free nuts (30 g/day). Diets were ad libitum. Changes in urine levels of F2-lsoprostane (F2-IP) and the DNA damage base 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxo-dG) were evaluated at 1-year trial.
   Results: After 1-year urinary F2-IP decreased in all groups, the decrease in MedDiet groups reaching a borderline significance versus that of the Control group. Urinary 8-oxo-dG was also reduced in all groups, with a higher decrease in both MedDiet groups versus the Control one (P < 0.001).
   Conclusions: MedDiet reduces oxidative damage to lipids and DNA in MetS individuals. Data from this study provide evidence to recommend the traditional MedDiet as a useful tool in the MetS management. Registered under Clinical Trials.gov Identifier no. NCT00123456. (C) 2012 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.
C1 [Teresa Mitjavila, Maria; Casillas, Rosario; Jose Moreno, Juan] Univ Barcelona, Dept Physiol, INSA, E-08007 Barcelona, Spain.
   [Fandos, Marta; Borrego, Silvia; Sanchez, Julia M.; Tormos, Carmen; Zaragoza, Cristobal; Saez, Guillermo T.] Univ Valencia, Dept Biochem & Mol Biol, Fac Med, INCLIVA, Valencia 46010, Spain.
   [Salas-Salvado, Jordi; Bullo, Monica] Univ Rovira & Virgili, Human Nutr Unit, IISPV, E-43201 Reus, Spain.
   [Salas-Salvado, Jordi; Bullo, Monica] Univ Rovira & Virgili, CIBER Physiopathol Obes & Nutr CIBEROBN, E-43201 Reus, Spain.
   [Covas, Maria-Isabel] IMIM Inst Recerca Hosp del Mar, Cardiovasc Risk & Nutr Res Grp, CIBER Physiopathol Obes & Nutr CIBEROBN, Barcelona, Spain.
   [Estruch, Ramon] Univ Barcelona, Dept Internal Med, IDIBABS, Hosp Clin, E-08007 Barcelona, Spain.
   [Lamuela-Raventos, Rosa] Univ Barcelona, Nutr & Food Sci Dept XaRTA, INSA, E-08007 Barcelona, Spain.
   [Corella, Dolores; Fito, Montserrat] Univ Valencia, Dept Prevent Med, Valencia 46010, Spain.
   [Angel Martinez-Gonzalez, Miguel] Univ Navarra, Dept Prevent Med & Publ Hlth, E-31080 Pamplona, Spain.
   [Cerda, Concha; Saez, Guillermo T.] CDB Gen Univ Hosp, Serv Clin Anal, Valencia, Spain.
   [Iradi, Antonio] Univ Valencia, Dept Physiol, Fac Med, Valencia 46010, Spain.
   [Chaves, Javier] Valencia Clin Hosp Res Fdn INCLIVA, Lab Genet Studies, Valencia, Spain.
C3 University of Barcelona; University of Valencia; Universitat Rovira i
   Virgili; Institut d'Investigacio Sanitaria Pere Virgili (IISPV); CIBER -
   Centro de Investigacion Biomedica en Red; CIBEROBN; Universitat Rovira i
   Virgili; CIBER - Centro de Investigacion Biomedica en Red; CIBEROBN;
   Hospital del Mar Research Institute; University of Barcelona; Hospital
   Clinic de Barcelona; University of Barcelona; University of Valencia;
   University of Navarra; University of Valencia
RP Sáez, GT (corresponding author), Univ Valencia, Dept Biochem & Mol Biol, Fac Med, Avda Blasco lbanez 15, Valencia 46010, Spain.
EM guillermo.saez@uv.es
RI Martinez-Gonzalez, Miguel/AAE-7669-2019; Tormo, Julia/JCD-8161-2023;
   Moreno, Juan/AAA-1312-2019; CHAVES, FELIPE/ABC-3294-2021; Corella,
   Dolores/L-9888-2014; Estruch, Ramon/AAZ-3723-2020; Salas-Salvado,
   Jordi/C-7229-2017; Mitjavila, Maria Teresa/D-7474-2014; Fito Colomer,
   Montse/C-1822-2012; Lamuela-Raventos, Rosa M/F-3986-2016; Bullo,
   Monica/F-2925-2016
OI Martinez-Gonzalez, Miguel A./0000-0002-3917-9808; Sanchez Tormo, Julia
   Maria/0000-0001-9341-8737; Salas-Salvado, Jordi/0000-0003-2700-7459;
   Mitjavila, Maria Teresa/0000-0002-1550-6253; Casillas,
   Rosario/0000-0002-6758-6734; Fito Colomer, Montse/0000-0002-1817-483X;
   Lamuela-Raventos, Rosa M/0000-0002-1287-4560; Bullo,
   Monica/0000-0002-0218-7046; Saez, Guillermo/0000-0002-8164-4048; CHAVES,
   FELIPE J/0000-0001-8009-3689
FU Spanish Ministry of Health Instituto de Salud Carlos III [PI1001407, FIS
   PI10/0082, G03/140, RD06/0045]; FEDER (Fondo Europeo de Desarrollo
   Regional); Public Health Division of the Department of Health of the
   Autonomous Government of Catalonia and Caixa Tarragona [10-1343]
FX This study was funded by the Spanish Ministry of Health Instituto de
   Salud Carlos III (PI1001407, FIS PI10/0082, G03/140, RD06/0045), FEDER
   (Fondo Europeo de Desarrollo Regional), the Public Health Division of
   the Department of Health of the Autonomous Government of Catalonia and
   Caixa Tarragona (10-1343). The Fundacion Patrimonio Comunal Olivarero
   and Hojiblanca SA (Malaga, Spain), California Walnut Commission
   (Sacramento, CA), Borges SA (Reus, Spain) and Morella Nuts SA (Reus,
   Spain) donated the olive oil, walnuts, almonds and hazelnuts,
   respectively, used in the PREDIMED study. None of the funding sources
   played a role in the design, collection, analysis or interpretation of
   the data or in the decision to submit the manuscript for publication.
   CIBER de Obesidad y Nutricion is an initiative of the Instituto de Salud
   Carlos III. The authors thank the participants for their enthusiastic
   collaboration, the PREDIMED personnel for excellent assistance and the
   personnel of all affiliated primary care centers.
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NR 44
TC 154
Z9 159
U1 0
U2 58
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0261-5614
EI 1532-1983
J9 CLIN NUTR
JI Clin. Nutr.
PD APR
PY 2013
VL 32
IS 2
BP 172
EP 178
DI 10.1016/j.clnu.2012.08.002
PG 7
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 115UV
UT WOS:000316838300003
PM 22999065
DA 2025-06-11
ER

PT J
AU Bo, S
   Gambino, R
   Durazzo, M
   Ghione, F
   Musso, G
   Gentile, L
   Cassader, M
   Cavallo-Perin, P
   Pagano, G
AF Bo, S.
   Gambino, R.
   Durazzo, M.
   Ghione, F.
   Musso, G.
   Gentile, L.
   Cassader, M.
   Cavallo-Perin, P.
   Pagano, G.
TI Associations between serum uric acid and adipokines, markers of
   inflammation, and endothelial dysfunction
SO JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
LA English
DT Article
DE uric acid; adipokines; inflammation; oxidative stress; endothelial
   dysfunction
ID C-REACTIVE PROTEIN; CORONARY-HEART-DISEASE; CARDIOVASCULAR-DISEASE;
   METABOLIC SYNDROME; ADHESION MOLECULES; CAROTID ATHEROSCLEROSIS;
   CELL-PROLIFERATION; INSULIN-RESISTANCE; LEPTIN; RISK
AB Aim: Serum uric acid is associated with the metabolic syndrome and its components, while its relationship with cardiovascular disease is controversial. The aim of the study was to evaluate the association between uric acid and adipokines, markers of inflammation, oxidative stress, and endothelial dysfunction, which are all linked to cardiovascular disease. Methods: The associations between uric acid and adiponectin, resistin, leptin, high-sensitivity-C-reactive protein (hs-CRP), interleukin-6, tumor necrosis factor-alpha, nitrotyrosine, Total Antioxidant Status (TAS), E-selectin, vascular adhesion molecule-1 (VCAM-1), and intercellular adhesion molecule-1 (ICAM-1) were cross-sectionally evaluated in a randomly collected sample of 100 men from a population-based cohort. Results: Subjects within the highest uric acid quartile showed a worse metabolic pattern and a higher prevalence of the metabolic syndrome [odds ratio (OR)=3.6; 95% confidence interval (CI) 1.6-8.2; p < 0.001 for each 50 mu mol/l uric acid increment in a logistic regression model after multiple adjustments]. Nitrotyrosine and adiponectin were significantly lower, while TAS, hs-CRP, E-selectin, ICAM-1, and VCAM-1 were higher in the groups with increased uric acid levels. In a multiple regression model, after adjustments for multiple con-founders, uric acid levels were inversely associated with nitrotyrosine (p < 0.001) and adiponectin (p=0.02), and directly with TAS (p < 0.001), and E-selectin (p=0.006). Conclusion: Serum uric acid showed opposite relationships, being associated with both beneficial (inverse association with nitrotyrosine, direct association with TAS) and detrimental (inverse association with adiponectin, direct association with E-selectin) markers, thus providing a possible explanation for the previously reported controversial and not linear association between uric acid and cardiovascular disease.
C1 [Bo, S.; Gambino, R.; Durazzo, M.; Ghione, F.; Musso, G.; Cassader, M.; Cavallo-Perin, P.; Pagano, G.] Univ Turin, Dept Internal Med, I-10126 Turin, Italy.
   [Gentile, L.] Hosp Asti, Diabet Clin, Asti, Italy.
C3 University of Turin
RP Bo, S (corresponding author), Univ Turin, Dept Internal Med, Corso Dogliotti 14, I-10126 Turin, Italy.
EM sbo@molinette.piemonte.it
RI GAMBINO, Roberto/AAC-7517-2022; Bo, Simona/AAC-1110-2019
OI Bo, Simona/0000-0001-6862-8628; DURAZZO, Marilena/0000-0003-2450-5911
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NR 43
TC 35
Z9 43
U1 0
U2 4
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0391-4097
EI 1720-8386
J9 J ENDOCRINOL INVEST
JI J. Endocrinol. Invest.
PD JUN
PY 2008
VL 31
IS 6
BP 499
EP 504
DI 10.1007/BF03346397
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 327HP
UT WOS:000257720500003
PM 18591880
DA 2025-06-11
ER

PT J
AU Hemingway, H
   Shipley, M
   Brunner, E
   Britton, A
   Malik, M
   Marmot, M
AF Hemingway, H
   Shipley, M
   Brunner, E
   Britton, A
   Malik, M
   Marmot, M
TI Does autonomic function link social position to coronary risk? The
   Whitehall II study
SO CIRCULATION
LA English
DT Article
DE disparities; metabolism; psychosocial factors; social factors; stress
ID HEART-RATE-VARIABILITY; SUDDEN CARDIAC DEATH; ALL-CAUSE MORTALITY;
   ATHEROSCLEROSIS RISK; METABOLIC SYNDROME; CARDIOVASCULAR MORTALITY;
   PSYCHOSOCIAL FACTORS; JOB CONTROL; DISEASE; STRESS
AB Background - Laboratory and clinical studies suggest that the autonomic nervous system responds to chronic behavioral and psychosocial stressors with adverse metabolic consequences and that this may explain the relation between low social position and high coronary risk. We sought to test this hypothesis in a healthy occupational cohort.
   Methods and Results - This study comprised 2197 male civil servants 45 to 68 years of age in the Whitehall II study who were undergoing standardized assessments of social position ( employment grade) and the psychosocial, behavioral, and metabolic risk factors for coronary disease previously found to be associated with low social position. Five-minute recordings of heart rate variability (HRV) were used to assess cardiac parasympathetic function (SD of N-N intervals and high-frequency power [0.15 to 0.40 Hz]) and the influence of sympathetic and parasympathetic function (low-frequency power [0.04 to 0.15 Hz]). Low employment grade was associated with low HRV (age-adjusted trend for each modality, P <= 0.02). Adverse behavioral factors ( smoking, exercise, alcohol, and diet) and psychosocial factors ( job control) showed age-adjusted associations with low HRV (P < 0.03). The age-adjusted mean low-frequency power was 319 ms(2) among those participants in the bottom tertile of job control compared with 379 ms2 in the other participants (P = 0.004). HRV showed strong (P < 0.001) linear associations with components of the metabolic syndrome ( waist circumference, systolic blood pressure, HDL cholesterol, triglycerides, and fasting and 2-hour postload glucose). The social gradient in prevalence of metabolic syndrome was explained statistically by adjustment for low-frequency power, behavioral factors, and job control.
   Conclusions - Chronically impaired autonomic function may link social position to different components of coronary risk in the general population.
C1 UCL, Dept Epidemiol & Publ Hlth, Int Ctr Hlth & Soc, Sch Med, London WC1E 6BT, England.
   St George Hosp, Sch Med, London, England.
C3 University of London; University College London; UCL Medical School;
   City St Georges, University of London
RP UCL, Dept Epidemiol & Publ Hlth, Int Ctr Hlth & Soc, Sch Med, 1-19 Torrington Pl, London WC1E 6BT, England.
EM h.hemingway@ucl.ac.uk
RI Malik, Marek/KCY-3775-2024; Brunner, Eric/H-2114-2011; Marmot,
   Michael/Y-3920-2019; Hemingway, Harry/C-1219-2009
OI Marmot, Michael/0000-0002-2431-6419; Malik, Marek/0000-0002-3792-1407;
   Hemingway, Harry/0000-0003-2279-0624; Brunner, Eric/0000-0002-0595-4474
FU AHRQ HHS [5 R01 HS06516] Funding Source: Medline; Medical Research
   Council [G0100222, G19/35, G8802774] Funding Source: Medline; NHLBI NIH
   HHS [2R01 HL-36310] Funding Source: Medline; NIA NIH HHS [R01
   AG13196-02] Funding Source: Medline
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NR 51
TC 166
Z9 182
U1 0
U2 15
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0009-7322
EI 1524-4539
J9 CIRCULATION
JI Circulation
PD JUN 14
PY 2005
VL 111
IS 23
BP 3071
EP 3077
DI 10.1161/CIRCULATIONAHA.104.497347
PG 7
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 935IF
UT WOS:000229773500010
PM 15939818
OA Bronze
DA 2025-06-11
ER

PT J
AU Aladdin, N
   Ghareib, SA
AF Aladdin, Noha
   Ghareib, Salah A.
TI Vitamin D3 Exerts a Neuroprotective Effect in Metabolic Syndrome Rats:
   Role of BDNF/TRKB/Akt/GS3Kβ Pathway
SO JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
LA English
DT Article
DE brain-derived neurotrophic factor (BDNF); cognitive dysfunction;
   metabolic syndrome; neuropathic pain; VitD3
ID CENTRAL-NERVOUS-SYSTEM; INSULIN-RESISTANCE; NEUROTROPHIC FACTOR;
   ALZHEIMERS-DISEASE; AMYLOID-BETA; D DEFICIENCY; HIGH-FAT; RECEPTOR;
   TRKB; BDNF
AB Metabolic syndrome (MetS) is usually associated with cognitive impairment, neuropathic pain, and reduced brain-derived neurotrophic factor (BDNF) levels. BDNF via tropomyosin receptor kinase B (TrkB) exerts neuroprotection by activating protein kinase B (Akt) to inhibit glycogen synthase kinase-3 beta (GSK3 beta). Although Vitamin D3 (VitD3) has demonstrated favorable metabolic and neuronal outcomes in MetS, the precise molecular mechanisms underlying its neuroprotective effects remain poorly elucidated. We aimed to test the hypothesis that VitD3 mitigates MetS-induced cognition deficits and neuropathic pain via modulating the BDNF/TRKB/Akt/GS3K beta signaling pathway. MetS was induced in male rats by 10% fructose-supplemented water and 3% salt-enriched diet. After 6 weeks, normal and MetS rats received either vehicle or VitD3 (10 mu g/kg/day) for an additional 6 weeks. Glycemic status, lipid profile, and behavioral changes were assessed. The advanced glycation end products (AGEs), and markers of inflammation (TNF-alpha and NF-kappa B), oxidative stress (malondialdehyde), and apoptosis (caspase3), as well as BDNF, TrkB, PI3K, Akt, GSK3 beta, phosphorylated tau, and amyloid beta (A beta) were assessed in the cerebral cortex. MetS rats had deteriorated glycemic and lipid profiles, higher AGEs, reduced levels of BDNF, TrkB, PI3K, and active Akt, along with increased GSK3 beta levels, inflammation, oxidative stress, and apoptosis. These changes were associated with higher levels of cognitive impairment markers phosphorylated tau and A beta, as well as behavioral changes indicative of cognitive impairment and neuropathic pain. VitD3 improved the cognitive and behavioral alterations, while mitigating the associated molecular derangements. Our results indicate that VitD3 may exert neuroprotective effects by modulating the BDNF/TrkB/PI3K/Akt/GSK3 beta signaling pathway.
C1 [Aladdin, Noha; Ghareib, Salah A.] Zagazig Univ, Fac Pharm, Dept Pharmacol & Toxicol, Zagazig, Egypt.
C3 Egyptian Knowledge Bank (EKB); Zagazig University
RP Aladdin, N (corresponding author), Zagazig Univ, Fac Pharm, Dept Pharmacol & Toxicol, Zagazig, Egypt.
EM rme2991@yahoo.com
RI Atteiah, salah/I-1537-2012
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NR 118
TC 0
Z9 0
U1 2
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1095-6670
EI 1099-0461
J9 J BIOCHEM MOL TOXIC
JI J. Biochem. Mol. Toxicol.
PD DEC
PY 2024
VL 38
IS 12
AR e70082
DI 10.1002/jbt.70082
PG 15
WC Biochemistry & Molecular Biology; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Toxicology
GA O6T1C
UT WOS:001372415900001
PM 39651608
DA 2025-06-11
ER

PT J
AU di Maio, G
   Monda, V
   Messina, A
   Polito, R
   Monda, M
   Tartaglia, N
   Ambrosio, A
   Pisanelli, D
   Asmundo, A
   di Nunno, N
   Ametta, A
   Villano, I
   Francavilla, VC
AF di Maio, Girolamo
   Monda, Vincenzo
   Messina, Antonietta
   Polito, Rita
   Monda, Marcellino
   Tartaglia, Nicola
   Ambrosio, Antonio
   Pisanelli, Daniela
   Asmundo, Alessio
   di Nunno, Nunzio
   Ametta, Alberto
   Villano, Ines
   Francavilla, Vincenzo Cristian
TI PHYSICAL ACTIVITY AND MODIFICATION OF LIFESTYLE INDUCE BENEFITS ON THE
   HEALTH STATUS
SO ACTA MEDICA MEDITERRANEA
LA English
DT Article
DE Metabolic syndrome (MS); obesity; cardiovascular diseases; diabetes;
   physical exercise; healthy lifestyle
ID METABOLIC SYNDROME; ABDOMINAL OBESITY; SKELETAL-MUSCLE; RISK-FACTORS;
   WEIGHT-LOSS; EXERCISE; INSULIN; MICROPARTICLES; INTERVENTION; POPULATION
AB Introduction: Metabolic syndrome (MS) includes a various factors such as hyperglycemia, high blood pressure and hypercholesterolemia that predispose individuals to the development of cardiovascular disease and diabetes. Furthermore, MS is strongly associated with obesity, indeed, it is well know that abdominal and/or visceral adipose tissue accumulation is a contributory cause of MS development. These diseases are associated with multiple metabolic toxicities resulting from the oxidative stress, which are the product of reactive oxygen species. In this scenario, a corrected nutrition and adequate physical activity are important measures against MS, obesity, aging and prevention of cardiovascular disease and cancer. In this regards, the healthy lifestyle, and in particular correct physical activity, represents one the epigenetic strategies against MS, having beneficial and anti-inflammatory effects, reducing the production of free radicals and the risk to development cardiovascular diseases and diabetes. The aim of this review is to discuss on physical activity and its role in modification of lyfestile inducing beneficial effect on health status.
   Material and method: We performed a data literature analysis from PubMed. We analyze data from multiple studies reporting that physical activity decreases body adiposity and the physical exercise reduces the far mass in a dose dependent. Physical activity decreases abdominal visceral and subcutaneous fat indipendently of changes in dietary energy intake in healthy, overweight and obese man and women, suggesting that training is critical in the treatment, or prevention, of MS. Also, it induces the expression of a many genes involved in the repair of cellular damage and reduces the expression of genes involved in the mechanisms of oxidative stress and inflammation, activating numerous metabolic pathways and down-regulating the production of mediators of inflammation and ROS production.
   Conclusion: the physical activity can be an efficient therapeutic approach in MS, promoting weight loss in obesity and reducing cardiovascular disease and diabetes risks.
C1 [di Maio, Girolamo; Monda, Vincenzo; Messina, Antonietta; Monda, Marcellino; Villano, Ines] Univ Campania Luigi Vanvitelli, Sect Human Physiol, Dept Expt Med, Naples, Italy.
   [di Maio, Girolamo; Monda, Vincenzo; Messina, Antonietta; Monda, Marcellino; Villano, Ines] Univ Campania Luigi Vanvitelli, Unit Dietet & Sport Med, Naples, Italy.
   [Polito, Rita] Univ Foggia, Dept Clin & Expt Med, Foggia, Italy.
   [Tartaglia, Nicola; Ambrosio, Antonio] Univ Foggia, Dept Med & Surg Sci, Foggia, Italy.
   [Pisanelli, Daniela] Riuniti Hosp, Foggia, Italy.
   [Asmundo, Alessio] Univ Messina, Sect Legal Med, Dept Biomed & Dent Sci & Morphol & Funct Images, Messina, Italy.
   [di Nunno, Nunzio] Univ Salento, Lecce, Italy.
   [Ametta, Alberto] Univ Foggia, Dept Econ, Foggia, Italy.
   [Francavilla, Vincenzo Cristian] Kore Univ Enna, Sch Engn Architecture & Motor Sci, Enna, Italy.
C3 Universita della Campania Vanvitelli; Universita della Campania
   Vanvitelli; University of Foggia; University of Foggia; University of
   Messina; University of Salento; University of Foggia; Universita Kore di
   ENNA
RP Polito, R (corresponding author), Univ Foggia, Dept Clin & Expt Med, Foggia, Italy.
EM rita.polito@unifg.it
RI Villano, Ines/ABU-5527-2022; Di Maio, Girolamo/HJI-6834-2023; MESSINA,
   ANTONIETTA/K-9366-2016; Di Nunno, Nunzio/L-6907-2015; Tartaglia,
   Nicola/AAD-7321-2019
OI Di Nunno, Nunzio/0000-0001-9409-1369; Di Maio,
   Girolamo/0000-0001-6305-2092; Francavilla, Vincenzo
   Cristian/0000-0002-7337-392X; VILLANO, INES/0000-0002-1755-358X;
   Tartaglia, Nicola/0000-0001-6845-7080; Monda,
   Marcellino/0000-0002-7184-218X
CR [Anonymous], 2013, CURR TOP TOXICOL
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NR 79
TC 9
Z9 9
U1 0
U2 6
PU CARBONE EDITORE
PI PALERMO
PA VIA QUINTINO SELLA, 68, PALERMO, 90139, ITALY
SN 0393-6384
EI 2283-9720
J9 ACTA MEDICA MEDITERR
JI Acta Medica Mediterr.
PY 2020
VL 36
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BP 1913
EP 1919
DI 10.19193/0393-6384_2020_3_299
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA LR5QL
UT WOS:000535749300101
DA 2025-06-11
ER

PT J
AU Alwahsh, SM
   Gebhardt, R
AF Alwahsh, Salamah Mohammad
   Gebhardt, Rolf
TI Dietary fructose as a risk factor for non-alcoholic fatty liver disease
   (NAFLD)
SO ARCHIVES OF TOXICOLOGY
LA English
DT Review
DE Insulin resistance; Inflammation; Metabolic syndrome (MetS); Gut
   microbiota; Herbal medicine; Biomarkers; The brain; Ethanol; Humans;
   Oxidative stress; Liver regeneration; ATP
ID INDUCED INSULIN-RESISTANCE; INDUCED HEPATIC STEATOSIS;
   PLASMINOGEN-ACTIVATOR INHIBITOR-1; NECROSIS-FACTOR-ALPHA; CONDITIONED
   FLAVOR PREFERENCES; URIC-ACID; OXIDATIVE STRESS; METABOLIC SYNDROME;
   SWEETENED BEVERAGES; LIPID-ACCUMULATION
AB Glucose is a major energy source for the entire body, while fructose metabolism occurs mainly in the liver. Fructose consumption has increased over the last decade globally and is suspected to contribute to the increased incidence of non-alcoholic fatty liver disease (NAFLD). NAFLD is a manifestation of metabolic syndrome affecting about one-third of the population worldwide and has progressive pathological potential for liver cirrhosis and cancer through non-alcoholic steatohepatitis (NASH). Here we have reviewed the possible contribution of fructose to the pathophysiology of NAFLD. We critically summarize the current findings about several regulators, and their potential mechanisms, that have been studied in humans and animal models in response to fructose exposure. A novel hypothesis on fructose-dependent perturbation of liver regeneration and metabolism is advanced. Fructose intake could affect inflammatory and metabolic processes, liver function, gut microbiota, and portal endotoxin influx. The role of the brain in controlling fructose ingestion and the subsequent development of NAFLD is highlighted. Although the importance for fructose (over)consumption for NAFLD in humans is still debated and comprehensive intervention studies are invited, understanding of how fructose intake can favor these pathological processes is crucial for the development of appropriate noninvasive diagnostic and therapeutic approaches to detect and treat these metabolic effects. Still, lifestyle modification, to lessen the consumption of fructose-containing products, and physical exercise are major measures against NAFLD. Finally, promising drugs against fructose-induced insulin resistance and hepatic dysfunction that are emerging from studies in rodents are reviewed, but need further validation in human patients.
C1 [Alwahsh, Salamah Mohammad; Gebhardt, Rolf] Univ Leipzig, Inst Biochem, Fac Med, Johannisallee 30, D-04103 Leipzig, Germany.
   [Alwahsh, Salamah Mohammad] Univ Edinburgh, MCR Ctr Regenerat Med, 5 Little France Dr, Edinburgh EH16 4UU, Midlothian, Scotland.
C3 Leipzig University; University of Edinburgh
RP Alwahsh, SM; Gebhardt, R (corresponding author), Univ Leipzig, Inst Biochem, Fac Med, Johannisallee 30, D-04103 Leipzig, Germany.; Alwahsh, SM (corresponding author), Univ Edinburgh, MCR Ctr Regenerat Med, 5 Little France Dr, Edinburgh EH16 4UU, Midlothian, Scotland.
EM alwahsh.salamah@gmail.com; Rolf.Gebhardt@medizin.uni-leipzig.de
FU Bundesministerium fur Forschung und Technologie (BMBF) [0315735]
FX This study was supported by grants from the Bundesministerium fur
   Forschung und Technologie (BMBF) in the framework of the Systems Biology
   initiative "Virtual Liver Network" to RG (Grant: 0315735).
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NR 166
TC 106
Z9 115
U1 5
U2 91
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0340-5761
EI 1432-0738
J9 ARCH TOXICOL
JI Arch. Toxicol.
PD APR
PY 2017
VL 91
IS 4
BP 1545
EP 1563
DI 10.1007/s00204-016-1892-7
PG 19
WC Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Toxicology
GA ER5CO
UT WOS:000398819200002
PM 27995280
DA 2025-06-11
ER

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   Gallini, C
   Costanzo, E
   Gensini, GF
AF Conti, Alberto
   Vanni, Simone
   Sammicheli, Lucia
   Raveggi, Serena
   Camaiti, Alberto
   Pieralli, Filippo
   Nozzoli, Carlo
   Gallini, Chiara
   Costanzo, Egidio
   Gensini, Gian Franco
TI Yield of nuclear scan strategy in chest pain unit evaluation of special
   populations
SO NUCLEAR MEDICINE COMMUNICATIONS
LA English
DT Article
DE chest pain; chest pain unit; coronary artery disease; diabetes mellitus;
   exercise stress testing; metabolic syndrome; myocardial perfusion
   imaging
ID EMISSION COMPUTED-TOMOGRAPHY; AMERICAN-HEART-ASSOCIATION;
   CORONARY-ARTERY-DISEASE; ST-SEGMENT ELEVATION; METABOLIC SYNDROME;
   EMERGENCY-ROOM; STRESS ECHOCARDIOGRAPHY; MYOCARDIAL-INFARCTION;
   CLINICAL-CARDIOLOGY; PROGNOSTIC VALUE
AB Background Patients with chest pain (CP) and nondiagnostic ECG represent heterogeneous population in whom the evaluation of coronary risk factors including metabolic syndrome (MetS) and diabetes mellitus (DM) might improve risk stratification.
   Methods We enrolled 798 consecutive CP patients; 14% presented with MetS and 10% with DM; the remaining 76% presented with other coronary risk profiles (others). All patients underwent maximal exercise tolerance test (ETT) and myocardial perfusion imaging (exercise-MPI). Those with positive testing underwent angiography, whereas the remaining patients were discharged and later followed up. Primary end-point was a composite of coronary stenoses greater than or equal to 50% documented by angiography or coronary events at follow-up.
   Results Patients with MetS or DM had significantly lower survival free from end-point than those patients without (P < 0.001). Exercise-MPI showed high negative predictive value in MetS, DM, and others (> 96%); however, positive predictive value was 69, 74, and 52%, respectively (P < 0.05). ETT alone showed negative predictive value (88%) which was significantly lower than exercise-MPI (98%), (MetS vs. others: P < 0.001, and DM vs. others: P=0.05). The area under the receiver-operating characteristic curves obtained from the multivariate model includes clinical data alone, clinical data and ETT results, or clinical data and exercise-MPI results increase progressively.
   Conclusion A nuclear scan strategy in special populations, including CP patients with MetS or DM, is a valuable tool for risk stratification and adds incremental prognostic value over clinical and ETT values. Nucl Med Commun 29:1106-1112 (c) 2008 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
C1 [Conti, Alberto; Vanni, Simone; Sammicheli, Lucia; Raveggi, Serena; Camaiti, Alberto; Pieralli, Filippo; Nozzoli, Carlo] Careggi Univ Hosp, Emergency Med & Chest Pain Unit, Florence, Italy.
C3 University of Florence; Azienda Ospedaliero Universitaria Careggi
RP Conti, A (corresponding author), Viale Matteotti 21, I-50121 Florence, Italy.
EM aaaconti@hotmail.com
RI Vanni, Simone/GLR-6148-2022; Pieralli, Filippo/HJH-9760-2023
OI Vanni, Simone/0000-0002-1201-5715; Pieralli, Filippo/0000-0002-1016-7432
CR Alexander CM, 2003, DIABETES, V52, P1210, DOI 10.2337/diabetes.52.5.1210
   Bholasingh R, 2003, J AM COLL CARDIOL, V41, P596, DOI 10.1016/S0735-1097(02)02897-8
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NR 25
TC 8
Z9 8
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0143-3636
EI 1473-5628
J9 NUCL MED COMMUN
JI Nucl. Med. Commun.
PD DEC
PY 2008
VL 29
IS 12
BP 1106
EP 1112
DI 10.1097/MNM.0b013e328310b361
PG 7
WC Radiology, Nuclear Medicine & Medical Imaging
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Radiology, Nuclear Medicine & Medical Imaging
GA 376DU
UT WOS:000261164200013
PM 18987533
DA 2025-06-11
ER

PT J
AU Shoier, NO
   Ghareib, SA
   Kothayer, H
   Alsemeh, AE
   El-Sayed, SS
AF Shoier, Nourhan O.
   Ghareib, Salah A.
   Kothayer, Hend
   Alsemeh, Amira Ebrahim
   El-Sayed, Shaimaa S.
TI Vitamin D3 mitigates myopathy and metabolic dysfunction in rats with
   metabolic syndrome: the potential role of dipeptidyl peptidase-4
SO NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
LA English
DT Article
DE Vitamin D3; Metabolic syndrome; Myopathy; DPP-4 inhibitors;
   Vildagliptin; Skeletal muscles
ID GLYCATION END-PRODUCTS; SKELETAL-MUSCLE; INSULIN-RESISTANCE; OXIDATIVE
   STRESS; D SUPPLEMENTATION; BLOOD-PRESSURE; HIGHLY POTENT; FRUCTOSE;
   VILDAGLIPTIN; ASSOCIATION
AB Metabolic syndrome is associated with vitamin D3 deficiency. This work aims to examine the efficacy of vitamin D3 in inhibiting MetS-induced myopathy and to determine whether the beneficial effects of vitamin D3 are mediated by the inhibition of dipeptidyl peptidase-4 (DPP-4). An in silico study investigated the potential effectiveness of vitamin D3 on the inhibition of the DPP-4 enzyme. An in vitro assay of the DPP-4 inhibitory effect of vitamin D3 was performed. In vivo and over 12 weeks, both diet (with 3% salt) and drinking water (with 10% fructose) were utilized to induce MetS. In the seventh week, rats received either vitamin D3, vildagliptin, a combination of both, or vehicles. Serum lipids, adipokines, glycemic indices, and glucagon-like peptide-1 (GLP-1), muscular glucose transporter type-4 (GLUT-4) content, DPP-4, adenosine monophosphate kinase (AMPK) activities, and Sudan Black B-stained lipids were assessed. Muscular reactive oxygen species (ROS), caspase-3, and desmin immunostaining were used to determine myopathy. MetS-induced metabolic dysfunction was ameliorated by vitamin D3, which also reduced intramuscular glycogen and lipid accumulation. This is demonstrated by the attenuation of MetS-induced myopathy by vitamin D3, decreased oxidative stress, increased desmin immuno-expression, and caspase-3 activity. Our in silico data demonstrated that vitamin D3 is capable of inhibiting DPP-4, which is further supported by biochemical findings. Vitamin D3 increased serum GLP-1, muscular AMPK activity, and GLUT-4 content, whereas the levels of muscular ROS were decreased in MetS. Vildagliptin and its combination with vitamin D3 yielded comparable results. It is suggested that the DPP-4 inhibitory potential of vitamin D3 is responsible for the amelioration of MetS-induced metabolic changes and myopathy.
C1 [Shoier, Nourhan O.; Ghareib, Salah A.; El-Sayed, Shaimaa S.] Zagazig Univ, Fac Pharm, Pharmacol & Toxicol Dept, Zagazig 44519, Egypt.
   [Kothayer, Hend] Zagazig Univ, Fac Pharm, Med Chem Dept, Zagazig, Egypt.
   [Alsemeh, Amira Ebrahim] Zagazig Univ, Fac Med, Human Anat & Embryol Dept, Zagazig, Egypt.
C3 Egyptian Knowledge Bank (EKB); Zagazig University; Egyptian Knowledge
   Bank (EKB); Zagazig University; Egyptian Knowledge Bank (EKB); Zagazig
   University
RP El-Sayed, SS (corresponding author), Zagazig Univ, Fac Pharm, Pharmacol & Toxicol Dept, Zagazig 44519, Egypt.
EM n.omoustafa22@pharmacy.zu.edu.eg; salahatteiah@pharmacy.zu.edu.eg;
   Hendo1311@hotmail.com; Aialsemeh@zu.edu.eg; ssothman@pharmacy.zu.edu.eg
RI El-Sayed, Shaimaa/HJB-0866-2022; Atteiah, salah/I-1537-2012; Kothayer,
   Hend/GRJ-5827-2022; Alsemeh, Amira/LWH-9728-2024
OI O.Shoier, Nourhan/0000-0002-4562-2191; El-Sayed,
   Shaimaa/0000-0003-2314-6144
FU Zagazig University
FX Acknowledgement We thank Dr. Marwa Abolfotouh for assissting with
   proofreading.
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NR 89
TC 0
Z9 0
U1 1
U2 3
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0028-1298
EI 1432-1912
J9 N-S ARCH PHARMACOL
JI Naunyn-Schmiedebergs Arch. Pharmacol.
PD APR
PY 2025
VL 398
IS 4
BP 3697
EP 3715
DI 10.1007/s00210-024-03439-3
EA OCT 2024
PG 19
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 1DD9W
UT WOS:001326987700005
PM 39356321
OA hybrid
DA 2025-06-11
ER

PT J
AU Incel-Uysal, P
   Akdogan, N
   Alli, N
   Oktem, A
   Candar, T
   Topcuoglu, C
   Turhan, T
AF Incel-Uysal, Pinar
   Akdogan, Nesthan
   Alli, Nuran
   Oktem, Ayse
   Candar, Tuba
   Topcuoglu, Canan
   Turhan, Turan
TI Assessment of Metabolic Profile and Ischemia-modified Albumin Level in
   Patients with Alopecia Areata: A Case-Control Study
SO INDIAN JOURNAL OF DERMATOLOGY
LA English
DT Article
DE Alopecia areata; ischemia-modified albumin; metabolic parameters; small
   dense low-density lipoprotein; visfatin
ID OXIDATIVE STRESS; COMORBIDITY PROFILES; VISFATIN; INFLAMMATION;
   BIOMARKER; ONSET
AB Background: Alopecia areata (AA) is an autoimmune-mediated hair follicle disorder. In the literature, there is no study evaluating metabolic syndrome and levels of ischemia-modified albumin (IMA) which is proposed as an oxidative stress biomarker in patients with AA. Aims: The aim was to investigate the presence of metabolic syndrome and the levels of IMA, small dense low-density lipoprotein (sd-LDL), and visfatin levels in AA patients. Settings and Design: A hospital-based cross-sectional study was undertaken among AA patients and controls. Subjects and Methods: Thirty-five patients with AA and 35 sex-, age-, and body mass index-matched healthy controls were enrolled. Clinical and laboratory parameters of metabolic syndrome were examined in all participants. Furthermore, IMA, sd-LDL, and visfatin levels were assessed and analyzed with regard to disease pattern, severity and extent, severity of alopecia tool score, duration, and recurrence. Results: The median IMA and adjusted IMA levels were significantly increased compared with controls (P<0.05 and P=0.002, respectively). Patients with pull test positivity displayed higher levels of adjusted IMA levels (P<0.05). In AA group, there was a positive correlation between adjusted IMA and waist circumference (r=0.443, P=0.008), adjusted IMA and triglyceride levels (r=0.535, P=0.001), and adjusted IMA and sd-LDL levels (r=0.46, P<0.05). We observed no statistically significant difference in fasting blood glucose and lipid profile, sd-LDL, and visfatin levels of the patients and healthy controls. Conclusions: AA patients and controls have similar metabolic profile. Raised levels of adjusted IMA levels may be associated with antioxidant/oxidant imbalance and with risk of cardiovascular disease.
C1 [Incel-Uysal, Pinar; Akdogan, Nesthan; Alli, Nuran; Oktem, Ayse] Ankara Numune Training & Res Hosp, Dept Dermatol, Ankara, Turkey.
   [Topcuoglu, Canan; Turhan, Turan] Ankara Numune Training & Res Hosp, Dept Med Biochem, Ankara, Turkey.
   [Candar, Tuba] Ufuk Univ, Dept Med Biochem, Fac Med, Ankara, Turkey.
C3 Ankara Numune Training & Research Hospital; Ankara Numune Training &
   Research Hospital; Ufuk University
RP Incel-Uysal, P (corresponding author), Ankara Numune Training & Res Hosp, Dept Dermatol, Ankara, Turkey.
EM pinarincel@hotmail.com
RI Incel Uysal, Pınar/C-6148-2019; öktem, ayşe/AIC-3378-2022; turhan,
   turan/CAH-5850-2022
OI Akdogan, Neslihan/0000-0002-1137-5399; Incel uysal,
   Pinar/0000-0002-4540-6560
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NR 35
TC 17
Z9 17
U1 0
U2 1
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, 400059, INDIA
SN 0019-5154
EI 1998-3611
J9 INDIAN J DERMATOL
JI Indian J. Dermatol.
PD JAN-FEB
PY 2019
VL 64
IS 1
BP 12
EP 18
DI 10.4103/ijd.IJD_238_18
PG 7
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA HH5MR
UT WOS:000455771700003
PM 30745629
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Fortuño, A
   Bidegain, J
   San José, G
   Robador, PA
   Landecho, MF
   Beloqui, O
   Díez, J
   Zalba, G
AF Fortuno, Ana
   Bidegain, Julen
   San Jose, Gorka
   Robador, Pablo A.
   Landecho, Manuel F.
   Beloqui, Oscar
   Diez, Javier
   Zalba, Guillermo
TI Insulin resistance determines phagocytic nicotinamide adenine
   dinucleotide phosphate oxidase overactivation in metabolic syndrome
   patients
SO JOURNAL OF HYPERTENSION
LA English
DT Article
DE insulin resistance; metabolic syndrome; monocyte/macrophage;
   nicotinamide adenine dinucleotide phosphate oxidase; superoxide
ID DEPENDENT SUPEROXIDE-PRODUCTION; OXIDATIVE STRESS; NAD(P)H OXIDASE;
   HUMAN ATHEROSCLEROSIS; SUBUNIT P22(PHOX); NADPH OXIDASES; NOX FAMILY;
   HYPERTENSION; EXPRESSION; OBESITY
AB Objective Metabolic syndrome (MetS) is associated with insulin resistance and increases the cardiovascular risk. Oxidative stress constitutes a potential mechanism that links insulin resistance and cardiovascular disease. The aim of this study was to analyze the relationship of NADPH oxidase activation with insulin resistance, and the effect of this interaction on the cardiovascular risk in MetS patients.
   Methods NADPH oxidase-dependent superoxide production and expression was evaluated by luminescence and western blot, respectively, in peripheral blood mononuclear cells obtained from 125 patients with MetS. Insulin resistance was defined by the homeostasis model assessment index. Matrix metalloproteinase-9 was quantified by enzyme-linked immunosorbent assay in plasma samples. To ascertain the mechanisms involved in vivo, we performed in-vitro experiments in cultured macrophages.
   Results Fifty- six percent of patients with MetS showed insulin resistance. Plasma matrix metalloproteinase-9 levels were higher (P < 0.05) in insulin-resistant patients than in patients with insulin sensitivity. NADPH oxidase-dependent superoxide production was augmented (P < 0.05) in insulin-resistant patients with respect to insulin-sensitive patients. The interaction between insulin resistance and abnormally high NADPH oxidase-mediated superoxide production was associated with the highest matrix metalloproteinase- 9 values. Increased NADPH oxidase-dependent superoxide production was significantly associated with higher NADPH oxidase p22(phox) expression in insulin-resistant than in insulin-sensitive patients. Interestingly, insulin upregulated p22(phox) in peripheral blood mononuclear cells and in murine macrophages.
   Conclusion Insulin resistance is associated with phagocytic NADPH oxidase activation. This association results in the highest cardiovascular risk in MetS patients. J Hypertens 27:1420-1430 (C) 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins.
C1 [Fortuno, Ana; Bidegain, Julen; San Jose, Gorka; Robador, Pablo A.; Diez, Javier; Zalba, Guillermo] Univ Navarra, Ctr Appl Med Res, Div Cardiovasc Sci, Pamplona 31008, Spain.
   [Landecho, Manuel F.; Beloqui, Oscar] Univ Navarra, Dept Internal Med, Pamplona 31008, Spain.
   [Diez, Javier] Univ Navarra, Dept Cardiol & Cardiovasc Surg, Univ Clin, Pamplona 31008, Spain.
C3 University of Navarra; University of Navarra; University of Navarra
RP Zalba, G (corresponding author), Univ Navarra, Ctr Appl Med Res, Div Cardiovasc Sci, Av Pio 12 55, Pamplona 31008, Spain.
EM gzalba@unav.es
RI Landecho, Manuel/D-9227-2013; ZALBA, GUILLERMO/AAB-6231-2019; Diez
   Martinez, Domingo Francisco Javier/D-7014-2017; Fortuno,
   Ana/C-6921-2017; San Jose, Gorka/K-7501-2017
OI Diez Martinez, Domingo Francisco Javier/0000-0002-3414-6919; Landecho,
   Manuel F/0000-0003-3234-8805; Beloqui Ruiz, Oscar/0000-0001-9542-3687;
   ZALBA, GUILLERMO/0000-0003-4616-1523; Fortuno, Ana/0000-0002-0796-4879;
   San Jose, Gorka/0000-0001-5878-1741
FU Foundation for Applied Medical Research (FIMA); Instituto de Salud
   Carlos III, Ministry of Health [RD06/0014/0008]; European Union
   [LSHMCT-2006- 037093]; Foundation MMA; Department of Health of
   Government of Navarra [25/2005]; Ministry of Science and Education
   [SAF2004-07910]; Ministry of Science and Culture [SAF2007-62533]
FX This study was funded through the agreement between the Foundation for
   Applied Medical Research (FIMA) and 'UTE project CIMA', by the red
   Tematica de Investigacion Cooperativa en Enfermedades Cardiovasculares
   (RECAVA) from the Instituto de Salud Carlos III, Ministry of Health
   (grant RD06/0014/0008), by the European Union (InGenious HyperCare,
   grant LSHMCT-2006- 037093), by the Foundation MMA, by the Department of
   Health of Government of Navarra (grant 25/2005), by the Ministry of
   Science and Education (grant SAF2004-07910) and by the Ministry of
   Science and Culture (grant SAF2007-62533), Spain.
CR Avogaro A, 2003, J CLIN ENDOCR METAB, V88, P1753, DOI 10.1210/jc.2002-021025
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   Ceolotto G, 2004, DIABETES, V53, P1344, DOI 10.2337/diabetes.53.5.1344
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   Delbosc S, 2005, ATHEROSCLEROSIS, V179, P43, DOI 10.1016/j.atherosclerosis.2004.10.018
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NR 31
TC 12
Z9 13
U1 0
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0263-6352
EI 1473-5598
J9 J HYPERTENS
JI J. Hypertens.
PD JUL
PY 2009
VL 27
IS 7
BP 1420
EP 1430
DI 10.1097/HJH.0b013e32832b1e8f
PG 11
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 467ZW
UT WOS:000267783800015
PM 19357530
DA 2025-06-11
ER

PT J
AU Vazquez-Prieto, MA
   Renna, NF
   Diez, ER
   Cacciamani, V
   Lembo, C
   Miatello, RM
AF Vazquez-Prieto, Marcela A.
   Renna, Nicolas F.
   Diez, Emiliano R.
   Cacciamani, Valeria
   Lembo, Carina
   Miatello, Roberto M.
TI Effect of Red Wine on Adipocytokine Expression and Vascular Alterations
   in Fructose-Fed Rats
SO AMERICAN JOURNAL OF HYPERTENSION
LA English
DT Article
DE adipocytokines; blood pressure; hypertension; metabolic syndrome;
   resistin; adiponectin; red wine
ID METABOLIC SYNDROME; INSULIN-RESISTANCE; EXPERIMENTAL-MODEL; OXIDATIVE
   STRESS; ANGIOTENSIN-II; ADIPOSE-TISSUE; DEFICIENT MICE; CELL-FUNCTION;
   ADIPONECTIN; ALCOHOL
AB BACKGROUND
   Imbalance in adipocytokines secretion is related to the development of metabolic syndrome (MS). In addition, moderate consumption of red wine (RW) decreases the risk of cardiovascular disease. The aim of this study was to evaluate the effects of moderate consumption of RW or ethanol (E) on adiponectin and resistin expression, and vascular alterations in fructose-fed rats (FFRs) as an experimental model of MS.
   METHODS
   Thirty-day-old male Wistar rats were assigned to control (C), F (10% fructose in drinking water), F+E (4.5 ml/kg), and F+RW (35 ml/kg of Malbec RW containing 4.5 ml/kg E). E and RW were administered during the last 4 weeks of a 10-week period.
   RESULTS
   RW administration to F rats was able to significantly decrease insulin resistance, mesenteric adipose tissue weight, and systolic blood pressure (SBP) compared to F group. F+E only reduced the SBP (P<0.05 vs. F). F+RW also reduced aortic NAD(P)H-oxidase activity, NAD(P)H subunits Nox4 expression in mesenteric tissue, plasma thiobarbituric acid reactive substances (TBARS), and recovered plasma total antioxidant activity (TAA) compared to F and F+E groups (P<0.05). Adiponectin expression decreased, whereas resistin, vascular cell adhesion molecules-1 (VCAM-1), and nuclear factor-kB (NF-kB) expression and vascular remodeling in mesenteric arteries were higher in F than in C group (P<0.05). Only RW was able to partially reverse the aforementioned alterations.
   CONCLUSION
   In this study, Malbec RW, but not alcohol alone, improved the balance of adipocytokines and attenuated the oxidative stress and vascular inflammation in a model of MS, suggesting that nonalcohol components of RW are responsible for the beneficial effects.
C1 [Vazquez-Prieto, Marcela A.; Renna, Nicolas F.; Diez, Emiliano R.; Cacciamani, Valeria; Lembo, Carina; Miatello, Roberto M.] Natl Univ Cuyo, Sch Med, Dept Pathol, Mendoza, Argentina.
   [Vazquez-Prieto, Marcela A.; Renna, Nicolas F.; Diez, Emiliano R.; Lembo, Carina; Miatello, Roberto M.] Consejo Nacl Invest Cient & Tecn, Natl Res Council, Inst Expt Med & Biol Res IMBECU, Lab Cardiovasc Pathophysiol, Mendoza, Argentina.
C3 University Nacional Cuyo Mendoza; Consejo Nacional de Investigaciones
   Cientificas y Tecnicas (CONICET)
RP Miatello, RM (corresponding author), Natl Univ Cuyo, Sch Med, Dept Pathol, Mendoza, Argentina.
EM rmiatell@fcm.uncu.edu.ar
RI Prieto, Marcela/W-4291-2019; Diez, Emiliano/KIB-2439-2024
OI Diez, Emiliano/0000-0001-5163-3703
FU National Council of Research [PIP 5192]; National University of Cuyo
FX This work was supported by a Grant from National Council of Research
   (PIP 5192) and Program I+D from the National University of Cuyo. The
   authors thank Susana Gonzalez and Cristina Lama for their technical
   assistance.
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NR 41
TC 20
Z9 21
U1 0
U2 4
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0895-7061
EI 1941-7225
J9 AM J HYPERTENS
JI Am. J. Hypertens.
PD FEB
PY 2011
VL 24
IS 2
BP 234
EP 240
DI 10.1038/ajh.2010.214
PG 7
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 709PC
UT WOS:000286451600017
PM 20885371
OA Bronze
DA 2025-06-11
ER

PT J
AU Vazquez-Prieto, MA
   Renna, NF
   Lembo, C
   Diez, ER
   Miatello, RM
AF Alejandra Vazquez-Prieto, Marcela
   Federico Renna, Nicolas
   Lembo, Carina
   Raul Diez, Emiliano
   Miguel Miatello, Roberto
TI Dealcoholized red wine reverse vascular remodeling in an experimental
   model of metabolic syndrome: role of NAD(P)H oxidase and eNOS activity
SO FOOD & FUNCTION
LA English
DT Article
ID PREVENTS ENDOTHELIAL DYSFUNCTION; SMOOTH-MUSCLE-CELLS; FRUCTOSE-FED
   RATS; NADPH OXIDASE; INSULIN-RESISTANCE; ANGIOTENSIN-II; DIETARY
   POLYPHENOLS; FRENCH PARADOX; NITRIC-OXIDE; HYPERTENSION
AB The present study examines the effect of chronic administration of dealcoholized red wine Malbec (DRW) on vascular remodeling and NAD(P)H oxidase and endothelial nitric oxide synthase activity (eNOS) in an experimental model of metabolic syndrome induced by fructose administration. Thirty-day old male Wistar rats were fed a normal rat diet (control) or the same diet plus 10% fructose in drinking water (FFR). During the last 4 weeks of a 10-week period of the corresponding diet, a subgroup of control and FFR (a = 8 each) received DRW in their drinking water. Systolic blood pressure (SBP), a homeostasis model assessment of insulin resistance (HOMA-IR), aortic NAD(P)H oxidase and eNOS activity in the heart and vascular tissue were evaluated. Vascular remodeling was evaluated in the left carotid artery (CA) and interlobar, arcuate and interlobular renal arteries (RA) through lumen to media (L/M) ratio determination. At the end of the study FFR increased the SBP (p < 0.001), HOMA-IR (p < 0.001), and aortic NAD(P)H oxidase activity (p < 0,05) but reduced cardiac and vascular eNOS activity (p < 0.01), L/M ratio in CA (p < 0.001) and RA (p < 0.01) compared with the C group. DRW reduced SBP (p < 0.05), aortic NAD(P)H oxidase (p < 0.05), and recovered eNOS activity (p < 0.001) and L/M in CA (p < 0.001) and RA (p < 0.001) compared with FFR. This study provides new data about the beneficial effect of DRW on oxidative stress and vascular remodeling in the experimental model of metabolic syndrome. Data suggest the participation of mechanisms involving oxidative stress in FFR alterations and the usefulness of natural antioxidant substances present in red wine in the reversion of these changes.
C1 [Alejandra Vazquez-Prieto, Marcela; Federico Renna, Nicolas; Lembo, Carina; Raul Diez, Emiliano; Miguel Miatello, Roberto] Univ Nacl Cuyo, Sch Med, Dept Pathol, RA-5500 Mendoza, Argentina.
   [Alejandra Vazquez-Prieto, Marcela; Federico Renna, Nicolas; Lembo, Carina; Raul Diez, Emiliano; Miguel Miatello, Roberto] Natl Council Res CONICET, Inst Expt Med & Biol Cuyo IMBECU, Mendoza, Argentina.
C3 University Nacional Cuyo Mendoza; Consejo Nacional de Investigaciones
   Cientificas y Tecnicas (CONICET); Instituto de Medicina y BiologIa
   Experimental de Cuyo (IMBECU)
RP Vazquez-Prieto, MA (corresponding author), Natl Council Res CONICET, Inst Expt Med & Biol Cuyo IMBECU, Mendoza, Argentina.
EM rmiatell@fcm.uncu.edu.ar
RI Diez, Emiliano/KIB-2439-2024; Prieto, Marcela/W-4291-2019
OI Diez, Emiliano/0000-0001-5163-3703
FU Universidad Nacional de Cuyo [06/P01]; CONICET [PIP-5192]
FX We thank Susana Gonzalez and Cristina Lama for their technical
   assistance. This work was supported by grants from Program 06/P01 SECTyP
   Universidad Nacional de Cuyo, and PIP-5192 CONICET.
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NR 30
TC 8
Z9 9
U1 0
U2 5
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PD OCT
PY 2010
VL 1
IS 1
BP 124
EP 129
DI 10.1039/c0fo00077a
PG 6
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA 758DG
UT WOS:000290140200010
PM 21776463
DA 2025-06-11
ER

PT J
AU Tápias, FS
   Otani, VHO
   Vasques, DAC
   Otani, TZS
   Uchida, RR
AF Tapias, Felipe Saia
   Oyamada Otani, Victor Henrique
   Correa Vasques, Daniel Augusto
   Santos Otani, Thais Zelia
   Uchida, Ricardo Riyoiti
TI Costs associated with depression and obesity among cardiovascular
   patients: medical expenditure panel survey analysis
SO BMC HEALTH SERVICES RESEARCH
LA English
DT Article
DE Depression; Cost; Cardiovascular conditions; Obesity
ID HEALTH-CARE COSTS; MAJOR DEPRESSION; ECONOMIC BURDEN; UNITED-STATES;
   PREVALENCE; DISEASE; OVERWEIGHT; OUTCOMES; PARADOX; ADULTS
AB Background There is a lack of information on the cost of depression associated with metabolic syndrome and cardiovascular diseases in the literature. Methods We evaluated the synergistic effects of depression and obesity on total expenditures for cardiovascular conditions using data from the Medical Expenditure Panel Survey (MEPS) database. We analyzed MEPS data from 1996 to 2017 comprising adult cardiovascular subjects. We categorized individuals following a combination of International Classification of Diseases ICD-9-CM and ICD-10 codes, and depression symptoms as evaluated using the Patient Health Questionnaire-2 (PHQ-2) depression screening tool. Our sample comprised cardiovascular patients aged 18 years and older, with a body mass index (BMI) between 18.5 and 60. Our study comprised unweighted sample of 96,697 (weighted sample of 938,835,031) adults, a US-nationwide representative sample of cardiovascular disease patients. The four response categories were: no depression; unrecognized depression; asymptomatic depression; and symptomatic depression. Our evaluated outcomes were total annual healthcare expenditures, including dental, emergency room, hospital outpatient, hospital inpatient, office-based, prescription, and home health care expenses. Results Asymptomatic and symptomatic depression was more frequent among obese individuals than in individuals with a normal BMI (p < 0.001). Total expenditure was highest among symptomatic depression individuals (17,536) and obese (9871) with cardiovascular disease. All the expenditure outcomes were significantly higher among symptomatic depression individuals than those without depression (p < 0.001), except for dental costs. All healthcare expenditures associated with obesity were higher compared to individuals with normal BMI with p < 0.001, except for emergency and home healthcare costs. Most importantly, among obese individuals, all healthcare expenditures were significantly higher (p < 0.001) in those with symptomatic depression than those without depression, except for dental costs, where the difference was not significant (0.899). Therefore, obesity and depression entail increased expenses in patients with cardiovascular disease. Conclusions We found incremental expenditures among unrecognized, asymptomatic, and symptomatic depressed individuals with obesity compared to non-depressed, non-obese subjects. However, these are preliminary results that should be further validated using different methodologies.
C1 [Tapias, Felipe Saia; Oyamada Otani, Victor Henrique; Correa Vasques, Daniel Augusto; Santos Otani, Thais Zelia; Uchida, Ricardo Riyoiti] Univ Med Sci Santa Casa Sao Paulo, Dr Cesario Motta Jr St 61, BR-01221020 Sao Paulo, SP, Brazil.
RP Tápias, FS (corresponding author), Univ Med Sci Santa Casa Sao Paulo, Dr Cesario Motta Jr St 61, BR-01221020 Sao Paulo, SP, Brazil.
EM felipetapias89@gmail.com
OI Otani, Victor/0000-0001-6337-6388
FU CAPES Brazil Coordination for the Improvement of Higher Education
   Personnel
FX The first author was granted a masters scholarship from CAPES Brazil
   Coordination for the Improvement of Higher Education Personnel over the
   course of this study. The funding body had no role in the design of the
   study, collection, analysis, and interpretation of data or the writing
   of this manuscript.
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NR 65
TC 6
Z9 8
U1 1
U2 10
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1472-6963
J9 BMC HEALTH SERV RES
JI BMC Health Serv. Res.
PD MAY 6
PY 2021
VL 21
IS 1
AR 433
DI 10.1186/s12913-021-06428-x
PG 14
WC Health Care Sciences & Services
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services
GA SK4ZK
UT WOS:000656225300003
PM 33957919
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Fernández-Abascal, B
   Suárez-Pinilla, P
   Cobo-Corrales, C
   Crespo-Facorro, B
   Suárez-Pinilla, M
AF Fernandez-Abascal, Blanca
   Suarez-Pinilla, Paula
   Cobo-Corrales, Carlos
   Crespo-Facorro, Benedicto
   Suarez-Pinilla, Marta
TI In- and outpatient lifestyle interventions on diet and exercise and
   their effect on physical and psychological health: a systematic review
   and meta-analysis of randomised controlled trials in patients with
   schizophrenia spectrum disorders and first episode of psychosis
SO NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
LA English
DT Review
DE non-affective psychosis; schizophrenia; non-pharmacological
   interventions; physical activity; exercise; psychoeducation; health
   promotion; cardiometabolic risk; quality of life; meta-analysis
ID INDUCED WEIGHT-GAIN; QUALITY-OF-LIFE; SINGLE-BLIND; YOGA THERAPY;
   METABOLIC ABNORMALITIES; MANAGEMENT PROGRAM; AEROBIC EXERCISE; TAI-CHI;
   NEUROCOGNITION; INDIVIDUALS
AB Patients with non-affective psychosis often lead unhealthy lifestyles. We performed a systematic review and meta-analysis on non-pharmacological RCTs for improvement of diet and physical activity in non-affective psychosis patients, including first-episode psychosis. A variety of outcomes was analysed, including metabolic, psychopathology, cognitive, functional and quality of life outcomes. Fifty-nine studies were included. An improvement in anthropometric measurements (BMI, weight, waist circumference) was observed postintervention, persisting after follow-up. Post-intervention benefit was found also for psychotic symptoms severity (also persisting after follow-up), many cognitive domains and physical and global functioning and quality of life. Conversely, no effect was observed in relation to most blood metabolites, blood pressure and nonpsychotic psychopathology and spontaneous physical activity. Improvement was generally larger for interventions including exercise, especially moderate/vigorous aerobic exercise, but follow-up maintenance was greater for psychotherapy interventions. Sensitivity analyses limited to chronic stages of psychosis and low risk of bias studies produced comparable results. Further studies are needed to design optimized interventions in this vulnerable population.
C1 [Fernandez-Abascal, Blanca; Suarez-Pinilla, Paula] Univ Hosp Marques Valdecilla, Dept Psychiat, IDIVAL, Santander 39011, Spain.
   [Suarez-Pinilla, Marta] UCL, Inst Neurol, Dept Neurodegenerat Dis, London WC1N 3AX, England.
   [Cobo-Corrales, Carlos] Univ Cantabria, Sch Educ, Santander 39005, Spain.
   [Crespo-Facorro, Benedicto] Univ Hosp Virgen del Rocio IBiS, Sch Med, Dept Psychiat, Seville 41013, Spain.
   [Suarez-Pinilla, Paula; Crespo-Facorro, Benedicto] Inst Salud Carlos III, Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid 28029, Spain.
C3 Hospital Universitario Marques de Valdecilla (HUMV); University of
   London; University College London; Universidad de Cantabria; Consejo
   Superior de Investigaciones Cientificas (CSIC); University of Sevilla;
   CSIC-JA-USE - Instituto de Biomedicina de Sevilla (IBIS); Virgen del
   Rocio University Hospital; CIBER - Centro de Investigacion Biomedica en
   Red; CIBERSAM; Instituto de Salud Carlos III
RP Fernández-Abascal, B; Suárez-Pinilla, P (corresponding author), Univ Hosp Marques Valdecilla, Dept Psychiat, IDIVAL, Santander 39011, Spain.; Suárez-Pinilla, M (corresponding author), UCL, Inst Neurol, Dept Neurodegenerat Dis, London WC1N 3AX, England.; Suárez-Pinilla, P (corresponding author), Inst Salud Carlos III, Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid 28029, Spain.; Fernández-Abascal, B (corresponding author), Univ Hosp Marques Valdecilla, Dept Psychiat, Avda Valdecilla S-N, Santander 39008, Spain.
EM blancafap@hotmail.com; p.suarez.pinilla@gmail.com
RI Crespo-Facorro, BENEDICTO/AAY-2238-2021; Suárez Pinilla,
   Marta/JHU-6581-2023
OI Suarez-Pinilla, Marta/0000-0002-6437-3741; Crespo-Facorro,
   Benedicto/0000-0003-0033-7132
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NR 136
TC 61
Z9 64
U1 3
U2 28
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0149-7634
EI 1873-7528
J9 NEUROSCI BIOBEHAV R
JI Neurosci. Biobehav. Rev.
PD JUN
PY 2021
VL 125
BP 535
EP 568
DI 10.1016/j.neubiorev.2021.01.005
EA MAR 2021
PG 34
WC Behavioral Sciences; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Behavioral Sciences; Neurosciences & Neurology
GA RW8DA
UT WOS:000646748800007
PM 33503476
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Cantuária, VL
   Rodrigues, CM
   Dias, IR
   Ottone, VD
   Costa, BO
   Godinho, LF
   Silva, G
   Schetino, MAA
   Rocha-Vieira, E
   Dias-Peixoto, MF
   Honorato-Sampaio, K
AF Cantuaria, Vinicius Lopes
   Rodrigues, Cintia Maria
   Dias, Isabella Rocha
   Ottone, Vinicius de Oliveira
   Costa, Bruna Oliveira
   Godinho, Lourdes Fernanda
   Silva, Gabriela
   Schetino, Marco Antonio Alves
   Rocha-Vieira, Etel
   Dias-Peixoto, Marco Fabricio
   Honorato-Sampaio, Kinulpe
TI Intense Caloric Restriction from Birth Protects the Heart Against
   Ischemia/Reperfusion Injury and Reduces Reactive Oxygen Species in
   Ovariectomized Rats
SO ANTIOXIDANTS
LA English
DT Article
DE menopause; diet; mitochondria; oxidative stress
ID ISCHEMIA-REPERFUSION INJURY; TERM DIETARY RESTRICTION; INDUCED OXIDATIVE
   STRESS; RESVERATROL SUPPLEMENTATION; MYOCARDIAL PROTECTION; ESTROGEN
   REPLACEMENT; INSULIN SENSITIVITY; GENE-EXPRESSION; BLOOD-PRESSURE; AGE
AB This study investigates the cardioprotective effects of intense caloric restriction (ICR) from birth in ovariectomized rats, a model of estrogen deficiency mimicking menopause. Our findings demonstrate that ICR significantly improved both basal and post-ischemic cardiac function, even in the absence of estrogens. The restricted animals exhibited enhanced cardiac contractility and relaxation, particularly after ischemia/reperfusion (I/R) injury, with superior functional recovery compared to control groups. Notably, ICR reduced key cardiometabolic risk factors, including blood pressure, heart rate, and adiposity, while improving glucose tolerance and insulin sensitivity. Additionally, while mitochondrial biogenesis remained unaffected, ICR preserved mitochondrial integrity by reducing the number of damaged mitochondria. This was linked to a reduction in oxidative stress, as evidenced by lower reactive oxygen species (ROS) production in the hearts of restricted animals. These results suggest that ICR offers a protective effect against cardiovascular dysfunction induced by estrogen depletion, potentially through enhanced antioxidant defenses and mitochondrial protection.
C1 [Cantuaria, Vinicius Lopes; Ottone, Vinicius de Oliveira; Schetino, Marco Antonio Alves; Rocha-Vieira, Etel; Honorato-Sampaio, Kinulpe] Univ Fed Vales Jequitinhonha & Mucuri, Fac Med, BR-39100000 Diamantina, MG, Brazil.
   [Cantuaria, Vinicius Lopes; Costa, Bruna Oliveira; Godinho, Lourdes Fernanda; Silva, Gabriela; Rocha-Vieira, Etel; Dias-Peixoto, Marco Fabricio; Honorato-Sampaio, Kinulpe] Univ Fed Vales Jequitinhonha & Mucuri, Programa Posgrad Ciencias Saude, BR-39100000 Diamantina, MG, Brazil.
   [Rodrigues, Cintia Maria; Dias, Isabella Rocha; Dias-Peixoto, Marco Fabricio] Univ Fed Vales Jequitinhonha & Mucuri, Fac Ciencias Biol & Saude, BR-39100000 Diamantina, MG, Brazil.
C3 Universidade Federal dos Vales do Jequitinhonha e Mucuri (UFVJM);
   Universidade Federal dos Vales do Jequitinhonha e Mucuri (UFVJM);
   Universidade Federal dos Vales do Jequitinhonha e Mucuri (UFVJM)
RP Honorato-Sampaio, K (corresponding author), Univ Fed Vales Jequitinhonha & Mucuri, Fac Med, BR-39100000 Diamantina, MG, Brazil.; Honorato-Sampaio, K (corresponding author), Univ Fed Vales Jequitinhonha & Mucuri, Programa Posgrad Ciencias Saude, BR-39100000 Diamantina, MG, Brazil.
EM vinicius.cantuaria@ufvjm.edu.br; cintia.rodrigues@ufvjm.edu.br;
   isabella.dias@ufvjm.edu.br; vinicius.ottone@ufvjm.edu.br;
   bruna.costa@ufvjm.edu.br; lourdes.godinho@ufvjm.edu.br;
   gabriela.silva@ufvjm.edu.br; marco.schetino@ufvjm.edu.br;
   etel.vieira@ufvjm.edu.br; marcofabri@ufvjm.edu.br; kinulpe@ufvjm.edu.br
RI Rodrigues, Cíntia/AIE-8410-2022; Honorato-Sampaio,
   Kinulpe/ACC-5742-2022; DIAS PEIXOTO, MARCO FABRICIO/AAC-7943-2022;
   Silva, Gabriela/MTA-5091-2025; Rocha-Vieira, Etel/A-2524-2017
OI Rocha-Vieira, Etel/0000-0001-6908-7237; Godinho,
   Lourdes/0000-0001-7068-2025; Honorato Sampaio,
   Kinulpe/0000-0002-8154-9606
FU FAPEMIG [APQ-01049-21, APQ-02363-22, APQ-04955-23]; Kinulpe Honorato
   Sampaio is a recipient of Conselho Nacional de Desenvolvimento
   Cientifico e Tecnologico (CNPq) [303206/2022-5]
FX This study was supported by (FAPEMIG) (APQ-01049-21; APQ-02363-22;
   APQ-04955-23), and Kinulpe Honorato Sampaio is a recipient of Conselho
   Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
   (303206/2022-5).
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U2 1
PU MDPI
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J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD FEB
PY 2025
VL 14
IS 2
AR 169
DI 10.3390/antiox14020169
PG 20
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA Y1P2M
UT WOS:001429925800001
PM 40002357
OA gold
DA 2025-06-11
ER

PT S
AU Yazici, D
   Sezer, H
AF Yazici, Dilek
   Sezer, Havva
BE Engin, AB
   Engin, A
TI Insulin Resistance, Obesity and Lipotoxicity
SO OBESITY AND LIPOTOXICITY
SE Advances in Experimental Medicine and Biology
LA English
DT Article; Book Chapter
DE Lipotoxicity; Insulin resistance; Type 2 diabetes mellitus; Obesity;
   Fatty acids; Diacylglycerol; Ceramides; Cytokines; Endoplasmic reticulum
   stress
ID TUMOR-NECROSIS-FACTOR; PROTEIN-KINASE-C; ENDOPLASMIC-RETICULUM STRESS;
   HUMAN SKELETAL-MUSCLE; NF-KAPPA-B; FREE FATTY-ACIDS; DEPENDENT
   DIABETES-MELLITUS; ADIPOSE TRIGLYCERIDE LIPASE; JUN NH2-TERMINAL KINASE;
   DIET-INDUCED OBESITY
AB Lipotoxicity, originally used to describe the destructive effects of excess fat accumulation on glucose metabolism, causes functional impairments in several metabolic pathways, both in adipose tissue and peripheral organs, like liver, heart, pancreas and muscle. Lipotoxicity has roles in insulin resistance and pancreatic beta cell dysfunction. Increased circulating levels of lipids and the metabolic alterations in fatty acid utilization and intracellular signaling, have been related to insulin resistance in muscle and liver. Different pathways, like novel protein kinase c pathways and the JNK-1 pathway are involved as the mechanisms of how lipotoxicity leads to insulin resistance in nonadipose tissue organs, such as liver and muscle. Mitochondrial dysfunction plays a role in the pathogenesis of insulin resistance. Endoplasmic reticulum stress, through mainly increased oxidative stress, also plays important role in the etiology of insulin resistance, especially seen in non-alcoholic fatty liver disease. Visceral adiposity and insulin resistance both increase the cardiometabolic risk and lipotoxicity seems to play a crucial role in the pathophysiology of these associations.
C1 [Yazici, Dilek] Koc Univ, Div Endocrinol & Metab, Fac Med, Davutpasa Cad 4, TR-34010 Istanbul, Turkey.
   [Sezer, Havva] Koc Univ, Div Endocrinol & Metab, Fac Med, Istanbul, Turkey.
C3 Koc University; Koc University
RP Yazici, D (corresponding author), Koc Univ, Div Endocrinol & Metab, Fac Med, Davutpasa Cad 4, TR-34010 Istanbul, Turkey.
EM dyazici@ku.edu.tr
RI Sezer, Havva/HNQ-3249-2023
OI Sezer, Havva/0000-0002-2730-7307
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SN 0065-2598
EI 2214-8019
BN 978-3-319-48382-5; 978-3-319-48380-1
J9 ADV EXP MED BIOL
JI Adv.Exp.Med.Biol.
PY 2017
VL 960
BP 277
EP 304
DI 10.1007/978-3-319-48382-5_12
D2 10.1007/978-3-319-48382-5
PG 28
WC Endocrinology & Metabolism; Medicine, Research & Experimental;
   Physiology
WE Book Citation Index – Science (BKCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Research & Experimental Medicine; Physiology
GA BS6WL
UT WOS:000753914500013
PM 28585204
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Sohi, G
   Revesz, A
   Hardy, DB
AF Sohi, Gurjeev
   Revesz, Andrew
   Hardy, Daniel B.
TI Nutritional mismatch in postnatal life of low birth weight rat offspring
   leads to increased phosphorylation of hepatic eukaryotic initiation
   factor 2 α in adulthood
SO METABOLISM-CLINICAL AND EXPERIMENTAL
LA English
DT Article
DE Fetal programming; Thrifty phenotype; Low protein diet; Metabolic
   syndrome; Protein translation; Growth; Endoplasmic reticulum stress;
   Predictive adaptive response hypothesis
ID ENDOPLASMIC-RETICULUM STRESS; XBP1 MESSENGER-RNA; INSULIN-RESISTANCE;
   METABOLIC SYNDROME; EARLY ORIGINS; EARLY GROWTH; PROTEIN; EXPRESSION;
   PRETERM; ADIPOSE
AB Objective. Epidemiological studies have established that low birth weight offspring, when faced with a nutritional mismatch in postnatal life, have an increased risk of developing the metabolic syndrome. Our laboratory and others have demonstrated that maternal protein restriction (MPR) leads to high cholesterol and insulin resistance in the offspring due to impaired liver function, though the underlying molecular mechanisms remain elusive. Recent in vitro studies have associated decreased phosphorylation of Akt1 (Serine 473), a marker of insulin sensitivity, with increased phosphorylation of eukaryotic initiation factor (eIF)-2 alpha (Serine 51), a key regulator of protein translation attenuation. The main aim of the study was to determine whether nutritional mismatch in MPR offspring leads to elevated phospho-eIF2 alpha (Ser51) levels in the liver.
   Materials/Methods. To investigate if this occurs long-term in MPR offspring, pregnant Wistar rats were fed a control (20%) protein diet (control) or a low (8%) protein diet during pregnancy and postnatal life (LP1), or during pregnancy and lactation (LP2).
   Results. At postnatal day 130, LP2 offspring exhibited increases in hepatic phosphorylation of eIF2 alpha (Ser51) concomitant with decreases in the phosphorylation of Akt1 (Ser473), while LP1 offspring exhibited the converse relationship. Interestingly, in embryonic day 19 livers derived from control or MPR pregnancy, no changes in eIF2 alpha (Ser51) or Ak1 (Ser473) phosphorylation were observed.
   Conclusion. Collectively, our data provide robust evidence that phosphorylation of eIF2 alpha (Ser51) is inversely correlated with phosphorylated Akt1 (Ser473) in vivo. Moreover, this study demonstrates that this inverse relationship is adversely influenced in these MPR offspring by a mismatch in the postnatal nutritional environment. (c) 2013 Elsevier Inc. All rights reserved.
C1 Univ Western Ontario, Childrens Hlth Res Inst, London, ON N6A 5C1, Canada.
   Univ Western Ontario, Lawson Hlth Res Inst, Dept Obstet & Gynecol & Physiol & Pharmacol, London, ON N6A 5C1, Canada.
C3 Western University (University of Western Ontario); Western University
   (University of Western Ontario); University Western Ontario Hospital
RP Hardy, DB (corresponding author), Univ Western Ontario, Dept Physiol & Pharmacol, London, ON N6A 5C1, Canada.
EM Daniel.Hardy@schulich.uwo.ca
RI Hardy, Daniel/GYU-8976-2022
OI Hardy, Daniel/0000-0001-5445-273X
FU CIHR Operating Grant [MOP 111001]; Natural Sciences and Engineering
   Research Council of Canada
FX Supported by: CIHR Operating Grant (MOP 111001) and Natural Sciences and
   Engineering Research Council of Canada.
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NR 41
TC 16
Z9 18
U1 0
U2 7
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0026-0495
EI 1532-8600
J9 METABOLISM
JI Metab.-Clin. Exp.
PD OCT
PY 2013
VL 62
IS 10
BP 1367
EP 1374
DI 10.1016/j.metabol.2013.05.002
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 226LJ
UT WOS:000325037400004
PM 23768545
DA 2025-06-11
ER

PT J
AU Vlajinac, H
   Marinkovic, J
   Maksimovic, M
   Kocev, N
   Vasiljevic, N
   Backovic, D
   Radak, D
AF Vlajinac, Hristina
   Marinkovic, Jelena
   Maksimovic, Milos
   Kocev, Nikola
   Vasiljevic, Nadja
   Backovic, Dusan
   Radak, Djordje
TI Health-related quality of life among patients with symptomatic carotid
   disease
SO POSTGRADUATE MEDICAL JOURNAL
LA English
DT Article
ID TRANSIENT ISCHEMIC ATTACK; STROKE PATIENTS; DEPRESSION; ENDARTERECTOMY;
   POPULATION; SURVIVORS; OUTCOMES; IMPACT; ADULTS; SF-36
AB Objectives To evaluate health-related quality of life (HRQoL) in patients with symptomatic carotid disease (amaurosis fugax, transient ischaemic attack, stroke); to compare it with that of the general population; to explore whether HRQoL depends on the severity of the disease and to investigate the possible association between some demographic and clinical characteristics of patients and HRQoL.
   Methods This cross-sectional study involved 175 patients with symptomatic carotid atherosclerotic disease who were referred for endarterectomy between January 2011 and December 2011. HRQoL was measured using Medical Outcome Survey Short Form 36 (SF-36).
   Results In comparison to both referent populations, patients with carotid disease had significantly lower mean SF-36 scores for role-physical (41.6 vs. 61.5 and 67.8), social functioning (65.4 vs. 73.8 and 80.0), role-emotional (48.2 vs. 68.6 and 80.5) and mental health (51.5 vs. 61.9 and 66.0). The SF-36 scores were significantly lower in female patients with carotid disease than in men (for role-physical 32.3 vs. 46.5; for bodily pain 57.0 vs. 73.0; for general health 55.6 vs. 61.5; for vitality 55.4 vs. 60.1; for social functioning 57.1 vs. 69.8 and for role-emotional 37.2 vs. 54.1). Significantly lower SF-36 scores were also found in patient with comorbidity (for physical functioning 68.1 vs. 77.7; for role-physical 35.1 vs. 52.3; for bodily pain 62.6 vs. 75.4; for general health 56.8 vs. 63.8; for social functioning 61.9 vs. 71.0, for role-emotional 41.6 vs. 59.1 and for mental health 52.5 vs 49.8). In a multivariable analysis, education, occupation, body mass index, metabolic syndrome and severity of the disease had a weak influence on patients' HRQoL, while age, marital status, smoking, alcohol consumption, physical activity and the degree of carotid stenosis had no effect on patients' HRQoL. The SF-36 scores did not substantially change after adjustment for confounding variables.
   Conclusions Patients with symptomatic carotid disease had poorer HRQoL, especially its mental components, than the general population. The severity of the disease was significantly associated only with the SF-36 role-physical subscale. HRQoL in patients with symptomatic carotid disease was poorer in women than in men, and was not affected by age and other demographic and clinical characteristics of patients.
C1 [Vlajinac, Hristina] Univ Belgrade, Fac Med, Inst Epidemiol, Belgrade 11000, Serbia.
   [Marinkovic, Jelena; Kocev, Nikola] Univ Belgrade, Fac Med, Inst Med Stat & Informat, Belgrade 11000, Serbia.
   [Maksimovic, Milos; Vasiljevic, Nadja; Backovic, Dusan] Univ Belgrade, Fac Med, Inst Hyg & Med Ecol, Belgrade 11000, Serbia.
   [Radak, Djordje] Univ Belgrade, Fac Med, Dept Vasc Surg, Dedinje Cardiovasc Inst, Belgrade 11000, Serbia.
C3 University of Belgrade; University of Belgrade; University of Belgrade;
   University of Belgrade
RP Vlajinac, H (corresponding author), Univ Belgrade, Fac Med, Inst Epidemiol, Visegradska 26, Belgrade 11000, Serbia.
EM kristiv@eunet.rs
RI Maksimović, Miloš/ABF-7728-2021
OI Vlajinac, Hristina/0000-0002-8239-2989; Maksimovic,
   Milos/0000-0002-6346-3171; Backovic, Dusan/0000-0002-3373-3628
FU Ministry of Education and Science, Serbia [III41002]
FX This work was supported by the Ministry of Education and Science,
   Serbia, through contract No III41002 (2011-2014).
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NR 36
TC 11
Z9 11
U1 0
U2 9
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 0032-5473
EI 1469-0756
J9 POSTGRAD MED J
JI Postgrad. Med. J.
PD JAN
PY 2013
VL 89
IS 1047
BP 8
EP 13
DI 10.1136/postgradmedj-2012-131005
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 057KI
UT WOS:000312561700003
PM 23043129
DA 2025-06-11
ER

PT J
AU Qiu, LJ
   Gao, CY
   Wang, HA
   Ren, Y
   Li, JX
   Li, MJ
   Du, XL
   Li, WJ
   Zhang, J
AF Qiu, Linjie
   Gao, Chunyang
   Wang, Haonan
   Ren, Yan
   Li, Jixin
   Li, Meijie
   Du, Xinlei
   Li, Wenjie
   Zhang, Jin
TI Effects of dietary polyphenol curcumin supplementation on metabolic,
   inflammatory, and oxidative stress indices in patients with metabolic
   syndrome: a systematic review and meta-analysis of randomized controlled
   trials
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Review
DE curcumin; turmeric; metabolic syndrome; inflammation; meta-analysis
ID DOUBLE-BLIND; WEIGHT-LOSS; OBESITY
AB Objective: The aim was to conduct a systematic review and meta-analysis for assessing the effectiveness and safety of dietary polyphenol curcumin supplement on metabolic, inflammatory, and oxidative stress indices in patients with metabolic syndrome (MetS).
   Methods: A comprehensive search for clinical trials was conducted in the following scientific databases: PubMed, SCOPUS, Cochrane Library, EMBASE, Web of Science, and China Biological Medicine. Randomized controlled trials (RCTs) evaluating the efficacy and safety of curcumin supplement for MetS were identified. A random-effects meta-analysis was performed using inverse variance, and efficacy was expressed as mean difference (MD) with 95% confidence interval (CI). The metabolic syndrome markers that were evaluated in the present study included waist circumference (WC), fasting blood sugar (FBS), systolic blood pressure (SBP), diastolic blood pressure (DBP), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), tumor necrosis factor-a (TNF-a), interleukin 6 (IL-6), C-reactive protein (CRP), ultrasensitive c-reactive protein (hsCRP), and malondialdehyde (MDA). By employing the Cochrane tool, RCTs were assessed for bias risk.
   Results: A total of 785 participants from 13 RCTs were included, with intervention durations ranging from 4 to 12 weeks. Compared with the control group, the curcumin group had positive effects on WC (MD = -2.16, 95% CI: -3.78 to -0.54, p = 0.009, seven studies), FBS (MD = -8.6, 95% CI: -15.45 to -1.75, p = 0.01, nine studies), DBP (MD = -2.8, 95% CI: -4.53 to - 1.06, p = 0.002, five studies), HDL-C (MD = 4.98, 95% CI: 2.58 to 7.38, p < 0.0001, eight studies), TNF-a (MD = -12.97, 95% CI: -18.37 to -7.57, p < 0.00001, two studies), CRP (MD = - 1.24, 95% CI: -1.71 to -0.77, p < 0.00001, two studies), and MDA (MD = -2.35, 95% CI: -4.47 to -0.24, p = 0.03, three studies). These improvements were statistically significant. Meanwhile, there was no significant improvement in SBP (MD = -4.82, 95% CI: -9.98 to 0.35, p = 0.07, six studies), TG (MD = 1.28, 95% CI: -3.75 to 6.30, p = 0.62, eight studies), IL-6 (MD = -1.5, 95% CI: -3.97 to 0.97, p = 0.23, two studies), or hsCRP (MD = -1.10, 95% CI: -4.35 to 2.16, p < 0.51, two studies). FBS, SBP, HDL-C, IL-6, CRP, hsCRP, and MDA had a relatively high heterogeneity.
   Conclusion: Curcumin exhibited promising potential in enhancing markers associated with metabolic syndrome, including inflammation. However, additional studies are required to confirm such findings since the included evidence is limited and has a relatively high heterogeneity.
C1 [Qiu, Linjie; Wang, Haonan; Ren, Yan; Li, Jixin; Li, Meijie; Du, Xinlei; Li, Wenjie; Zhang, Jin] China Acad Chinese Med Sci, Xiyuan Hosp, Beijing, Peoples R China.
   [Gao, Chunyang] Peking Univ, Dept Special Needs Int Med, Int Hosp, Beijing, Peoples R China.
C3 Xiyuan Hospital, CACMS; China Academy of Chinese Medical Sciences;
   Peking University
RP Zhang, J (corresponding author), China Acad Chinese Med Sci, Xiyuan Hosp, Beijing, Peoples R China.
EM zjmzy2000@hotmail.com
RI Li, Jixin/GSN-5182-2022; Li, Wenjie/ABB-7358-2021; LI,
   Meijie/ABA-9381-2021
FU Science and Technology Innovation Project of the Chinese Academy of
   Traditional Chinese Medicine [CI2021A03005]
FX Funding This study was funded by the Science and Technology Innovation
   Project of the Chinese Academy of Traditional Chinese Medicine
   (CI2021A03005).
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NR 60
TC 23
Z9 24
U1 1
U2 7
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD JUL 14
PY 2023
VL 14
AR 1216708
DI 10.3389/fendo.2023.1216708
PG 13
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA N4QY9
UT WOS:001036889400001
PM 37522129
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Pouwer, F
   Nijpels, G
   Beekman, AT
   Dekker, JM
   van Dam, RM
   Heine, RJ
   Snoek, FJ
AF Pouwer, F
   Nijpels, G
   Beekman, AT
   Dekker, JM
   van Dam, RM
   Heine, RJ
   Snoek, FJ
TI Fat food for a bad mood.: Could we treat and prevent depression in type
   2 diabetes by means of ω-3 polyunsaturated fatty acids?: A review of the
   evidence
SO DIABETIC MEDICINE
LA English
DT Article
DE diabetes; depression; omega-3 polyunsaturated fatty acids;
   phospholipids; metabolic syndrome
ID PRELIMINARY DOUBLE-BLIND; IMPAIRED GLUCOSE-TOLERANCE; FISH-OIL
   SUPPLEMENTATION; PLACEBO-CONTROLLED TRIAL; CORONARY-ARTERY-DISEASE;
   BLOOD-CELL MEMBRANES; MAJOR DEPRESSION; CARDIOVASCULAR-DISEASE;
   DIETARY-FAT; OMEGA-3-FATTY-ACID LEVELS
AB Aims Evidence strongly suggests that depression is a common complication of Type 2 diabetes mellitus. However, there is considerable room to improve the effectiveness of pharmacological antidepressant agents, as in only 50-60% of the depressed subjects with diabetes does pharmacotherapy lead to remission of depression. The aim of the present paper was to review whether polyunsaturated fatty acids (PUFA) of the omega-3 family could be used for the prevention and treatment of depression in Type 2 diabetes.
   Methods MEDLINE database and published reference lists were used to identify studies that examined the associations between omega-3 PUFA and depression. To examine potential side-effects, such as on glycaemic control, studies regarding the use of omega-3 supplements in Type 2 diabetes were also reviewed.
   Results Epidemiological and clinical studies suggest that a high intake of omega-3 PUFA protects against the development of depression. There is also some evidence that a low intake of omega-3 is associated with an increased risk of Type 2 diabetes, but the results are less conclusive. Results from randomized controlled trials in non-diabetic subjects with major depression show that eicosapentaenoic acid is an effective adjunct treatment of depression in diabetes, while docosahexanoic acid is not. Moreover, consumption of omega-3 PUFA reduces the risk of cardiovascular disease and may therefore indirectly decrease depression in Type 2 diabetes, via the reduction of cardiovascular complications.
   Conclusions Supplementation with omega-3 PUFA, in particular eicosapentaenoic acid, may be a safe and helpful tool to reduce the incidence of depression and to treat depression in Type 2 diabetes. Further studies are now justified to test these hypotheses in patients with Type 2 diabetes.
C1 Vrije Univ Amsterdam, Med Ctr, EMGO Inst, Amsterdam, Netherlands.
   Vrije Univ Amsterdam, Med Ctr, Dept Med Psychol, Amsterdam, Netherlands.
   Vrije Univ Amsterdam, Med Ctr, Fac Earth & Life Sci, Dept Nutr & Hlth, Amsterdam, Netherlands.
C3 Vrije Universiteit Amsterdam; Vrije Universiteit Amsterdam; Vrije
   Universiteit Amsterdam
RP Pouwer, F (corresponding author), Vrije Univ Amsterdam, Med Ctr, EMGO Inst, Amsterdam, Netherlands.
EM pouwer@vumc.nl
RI Beekman, Aartjan T./LUZ-6919-2024; van Dam, Rob/F-9674-2010; van Dam,
   Rob/A-6693-2009
OI Pouwer, Frans/0000-0002-8172-9818; Snoek, Frank/0000-0001-9563-6762; van
   Dam, Rob/0000-0002-7354-8734
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NR 73
TC 18
Z9 23
U1 0
U2 21
PU BLACKWELL PUBLISHING
PI OXFORD
PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND
SN 0742-3071
J9 DIABETIC MED
JI Diabetic Med.
PD NOV
PY 2005
VL 22
IS 11
BP 1465
EP 1475
DI 10.1111/j.1464-5491.2005.01661.x
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 976ZL
UT WOS:000232772100002
PM 16241908
DA 2025-06-11
ER

PT J
AU Hao, XZ
   Yuan, J
   Dong, HX
AF Hao, Xiuzhen
   Yuan, Jie
   Dong, Huixiao
TI Salidroside prevents diabetes-induced cognitive impairment via
   regulating the Rho pathway
SO MOLECULAR MEDICINE REPORTS
LA English
DT Article
DE salidroside; diabetes; cognitive impairment; Rho; nuclear factor-B
ID CARDIOMETABOLIC RISK; GLYCEMIC CONTROL; DEFICITS; INTERVENTION;
   INFLAMMATION; DYSFUNCTION; ACTIVATION; EXERCISE; STRESS; ADULTS
AB In previous years, it has been found that Rhodiola has a wide range of pharmacological effects in diseases of the cardiovascular system, as it can remove superoxide anions and hydroxyl radicals in chemical reactions. Behavioral assessment was used to measure cognitive impairment. Inflammation, oxidative stress and caspase-3 activity were measured using commercial kits. Western blot analysis was used to measure Rho/Rho-associated kinase (ROCK)/sirtuin 1 (SIRT1)/nuclear factor (NF)-B protein expression. The objective of the present study was to investigate the protective effect of salidroside on diabetes and diabetes-induced cognitive impairment. The results of the study demonstrated that salidroside prevented cognitive impairment, decreased serum blood glucose levels and increased body weight, reduced fasting blood glucose levels and blood lipid levels, and inhibited oxidative stress, inflammation and nerve cell apoptosis in the diabetic rat model. Salidroside suppressed ROCK/ SIRT1 NF-B pathway and protein expression in the diabetic rats. These data showed that salidroside prevented diabetes-induced cognitive impairment by regulating the Rho/ROCK/SIRT1/NF-B pathway.
C1 [Hao, Xiuzhen; Dong, Huixiao] Jining 1 Peoples Hosp, Dept Neurosurg, 6 Jiankang Rd, Jining 272000, Shandong, Peoples R China.
   [Yuan, Jie] North China Univ Sci & Technol, Inst Mental Hlth, Tangshan 063009, Hebei, Peoples R China.
C3 North China University of Science & Technology
RP Dong, HX (corresponding author), Jining 1 Peoples Hosp, Dept Neurosurg, 6 Jiankang Rd, Jining 272000, Shandong, Peoples R China.
EM dovlbm13964@126.com
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NR 31
TC 19
Z9 19
U1 1
U2 26
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1791-2997
EI 1791-3004
J9 MOL MED REP
JI Mol. Med. Rep.
PD JAN
PY 2019
VL 19
IS 1
BP 678
EP 684
DI 10.3892/mmr.2018.9621
PG 7
WC Oncology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Research & Experimental Medicine
GA HF7PE
UT WOS:000454431000074
PM 30387819
OA Bronze
DA 2025-06-11
ER

PT J
AU Piegza, M
   Pudlo, R
   Badura-Brzoza, K
   Piegza, J
   Szygula-Jurkiewicz, B
   Gorczyca, P
   Polonski, L
AF Piegza, Magdalena
   Pudlo, Robert
   Badura-Brzoza, Karina
   Piegza, Jacek
   Szygula-Jurkiewicz, Bozena
   Gorczyca, Piotr
   Polonski, Lech
TI Dynamics of anxiety in women undergoing coronary angiography
SO KARDIOLOGIA POLSKA
LA English
DT Article
DE anxiety; coronary artery disease; coronary angiography; somatoform
   disorders; cardiac syndrome X
ID HEART-DISEASE; PHOBIC ANXIETY; CHEST-PAIN; RISK; ARTERIOGRAPHY;
   REVASCULARIZATION; SYMPTOMS; FEARS; MEN
AB Background: Anxiety is a common and serious problem in ischaemic heart disease. Anxiety-associated somatisation disorders may imitate symptoms of coronary artery disease or coexist with ischaemic heart disease. Despite multiple visits to various specialists, patients with somatisation are frequently misdiagnosed and therefore mistreated. Identification of patients with anxiety disorders among patients complaining of chest pain is a prerequisite for appropriate management. By its nature, coronary angiography is a diagnostic test that can give rise to anxiety. However, dynamics of anxiety in this setting may be variable depending on coexisting mental disorders.
   Aim: The purpose of this study was to determine whether the presence of significant atherosclerotic lesions in coronary arteries affects anxiety level changes following coronary angiography.
   Methods: A group of 90 female patients who underwent coronary angiography was divided into two groups: the first one included 48 patients without significant coronary stenoses, and the other one included 42 patients with confirmed significant atherosclerotic lesions. Dynamics of anxiety level changes from the hospital admission, through the post-examination period, until 6 to 9 months after coronary angiography was evaluated with three-time measurement of anxiety using the Spielberger's State-Trait Anxiety Inventory. In addition, intensity of anxiety as a trait was measured twice (at the first and the third examination).
   Results: The highest intensity of anxiety as a state was noted in both groups at the first measurement. A significant reduction in anxiety was observed at the second measurement, more pronounced in the group without significant coronary lesions. At the third measurement, women with confirmed significant coronary lesions showed the lowest level of anxiety, while the level of anxiety increased compared to the second measurement in the group of patients without significant coronary lesions. At the third measurement, women without significant coronary lesions showed a significantly higher level of anxiety compared to the group with significant coronary lesions. Intensity of anxiety as a trait was significantly lower at the final measurement in the group of patients with confirmed significant coronary stenoses.
   Conclusions: In women demonstrating no significant atherosclerotic lesions in coronary angiography, anxiety does not resolve permanently but reappears after several months. In this group, is seems justified to consider a diagnosis of an anxiety disorder in the form of a somatoform disorder. Those patients should be offered psychiatric therapy.
C1 [Piegza, Magdalena; Pudlo, Robert; Badura-Brzoza, Karina; Gorczyca, Piotr] Med Univ Silesia, Div Dent Zabrze, Sch Med, Chair & Clin Dept Psychiat Tarnowskie Gory, Katowice, Poland.
   [Piegza, Jacek; Szygula-Jurkiewicz, Bozena; Polonski, Lech] Med Univ Silesia, Sch Med, Div Dent Zabrze, Chair & Clin Dept Cardiol 3, Katowice, Poland.
C3 Medical University of Silesia; Medical University of Silesia
RP Pudlo, R (corresponding author), Chair & Clin Dept Psychiat Tarnowskie Gory, Ul Pyskowicka 49, PL-42612 Tarnowskie Gory, Poland.
EM rpudlo@sum.edu.pl
RI Pudlo, Robert/HKF-1660-2023
OI Piegza, Magdalena/0000-0001-7228-5349; Piegza,
   Magdalena/0000-0002-8009-7118; Badura-Brzoza,
   Karina/0000-0002-1810-9018; Pudlo, Robert/0000-0002-5748-0063; Piegza,
   Jacek/0000-0002-7356-4769; Gorczyca, Piotr/0000-0002-9419-7988
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NR 22
TC 6
Z9 6
U1 0
U2 8
PU VIA MEDICA
PI GDANSK
PA UL SWIETOKRZYSKA 73, 80-180 GDANSK, POLAND
SN 0022-9032
EI 1897-4279
J9 KARDIOL POL
JI Kardiol. Pol.
PY 2014
VL 72
IS 2
BP 175
EP 180
DI 10.5603/KP.a2013.0214
PG 6
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA AC7PB
UT WOS:000332721700010
PM 23990234
OA hybrid
DA 2025-06-11
ER

EF﻿FN Clarivate Analytics Web of Science
VR 1.0
PT J
AU van Beers, M
   Janssen, DJA
   Gosker, HR
   Schols, AMWJ
AF van Beers, Martijn
   Janssen, Daisy J. A.
   Gosker, Harry R.
   Schols, Annemie M. W. J.
TI Cognitive impairment in chronic obstructive pulmonary disease: disease
   burden, determinants and possible future interventions
SO EXPERT REVIEW OF RESPIRATORY MEDICINE
LA English
DT Review
DE COPD; cognitive impairment; pathology
ID METABOLIC SYNDROME; SELF-MANAGEMENT; DIETARY PATTERNS; BODY-COMPOSITION;
   COPD PATIENTS; EXECUTIVE FUNCTION; ACUTE EXACERBATION;
   SMOKING-CESSATION; CHRONIC STRESS; OLDER-ADULTS
AB Introduction: Cognitive impairment (CI) is an important but an under-recognized extra-pulmonary feature of chronic obstructive pulmonary disease (COPD). It is related to the burden of disability, worse health outcomes, and impaired self-management. Areas covered: CI includes deterioration of a wide range of cognitive functions, such as memory and various executive functions. Risk of hospitalization might be higher in patients with COPD compared to those without, with CI negatively impacting the wellbeing of patients with COPD. Disease-specific factors such as hypoxemia and inflammation, lifestyle factors such as dietary insufficiencies and lack of physical activity, and comorbidities such as obstructive sleep apnea and depression are likely to synergistically contribute to the development of CI in COPD. Tailored interventions can possibly improve CI in COPD, but this needs further investigation. Expert commentary: Further research is warranted involving the optimization of neuropsychological testing for screening and outcome assessment, longitudinal studies to investigate the development of CI in COPD over time, and randomized clinical trials to test the feasibility and efficacy of promising interventions.
C1 [van Beers, Martijn; Gosker, Harry R.; Schols, Annemie M. W. J.] Maastricht Univ, NUTRIM Sch Nutr & Translat Res Metab, Dept Resp Med, Med Ctr, Maastricht, Netherlands.
   [Janssen, Daisy J. A.] Ctr Expertise Chron Organ Failure, Dept Res & Educ, CIRO, Horn, Netherlands.
   [Janssen, Daisy J. A.] Maastricht Univ, Ctr Expertise Palliat Care, Med Ctr, Maastricht, Netherlands.
C3 Maastricht University; Maastricht University Medical Centre (MUMC);
   Maastricht University
RP van Beers, M (corresponding author), Maastricht Univ, Dept Resp Med, Med Ctr, POB 5800, NL-6202 AZ Maastricht, Netherlands.
EM martijn.vanbeers@maastrichtuniversity.nl
RI Janssen, Daisy/AAW-2248-2021
OI Janssen, Daisy/0000-0002-1827-9869; van Beers,
   Martijn/0000-0001-6193-3160; Gosker, Harry/0000-0002-7659-0225
FU Netherlands Lung Foundation [3.4.09.003]; ZonMW (JPI-HDHL 'Ambrosiac'
   grant)
FX This study was supported by grants from the Netherlands Lung Foundation
   (grant 3.4.09.003) and ZonMW (JPI-HDHL 'Ambrosiac' grant).
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NR 146
TC 33
Z9 34
U1 2
U2 31
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1747-6348
EI 1747-6356
J9 EXPERT REV RESP MED
JI Expert Rev. Respir. Med.
PD DEC 2
PY 2018
VL 12
IS 12
BP 1061
EP 1074
DI 10.1080/17476348.2018.1533405
PG 14
WC Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Respiratory System
GA HC7RP
UT WOS:000451999500009
PM 30296384
OA Green Published
DA 2025-06-11
ER

PT J
AU Balog, M
   Miljanovic, M
   Blazetic, S
   Labak, I
   Ivic, V
   Viljetic, B
   Borbely, A
   Papp, Z
   Blazekovic, R
   Vari, SG
   Fagyas, M
   Heffer, M
AF Balog, Marta
   Miljanovic, Milan
   Blazetic, Senka
   Labak, Irena
   Ivic, Vedrana
   Viljetic, Barbara
   Borbely, Attila
   Papp, Zoltan
   Blazekovic, Robert
   Vari, Sandor G.
   Fagyas, Miklos
   Heffer, Marija
TI Sex-specific chronic stress response at the level of adrenal gland
   modified sexual hormone and leptin receptors
SO CROATIAN MEDICAL JOURNAL
LA English
DT Article
ID PSYCHOSOCIAL STRESS; ANDROGEN RECEPTORS; ESTROGEN-RECEPTORS;
   BODY-WEIGHT; RATS; EXPRESSION; AXIS; IMMUNOREACTIVITY; PROGESTERONE;
   TESTOSTERONE
AB Aim To compare cardiometabolic risk-related biochemical markers and sexual hormone and leptin receptors in the adrenal gland of rat males, non-ovariectomized females (NON-OVX), and ovariectomized females (OVX) under chronic stress.
   Methods Forty six 16-week-old Sprague-Dawley rats were divided into male, NON-OVX, and OVX group and exposed to chronic stress or kept as controls. Weight, glucose tolerance test (GTT), serum concentration of glucose, and cholesterol were measured. Adrenal glands were collected at the age of 28 weeks and immunohistochemical staining against estrogen beta (ER beta), progesterone (PR), testosterone (AR), and leptin (Ob-R) receptors was performed.
   Results Body weight, GTT, serum cholesterol, and glucose changed in response to stress as expected and validated the applied stress protocol. Stressed males had significantly higher number of ER beta receptors in comparison to control group (P = 0.028). Stressed NON-OVX group had significantly decreased AR in comparison to control group (P = 0.007). The levels of PR did not change in any consistent pattern. The levels of Ob-R increased upon stress in all groups, but the significant difference was reached only in the case of stressed OVX group compared to control (P = 0.033).
   Conclusion Chronic stress response was sex specific. OVX females had similar biochemical parameters as males. Changes upon chronic stress in adrenal gland were related to an increase in testosterone receptor in females and decrease in estrogen receptor in males.
C1 [Balog, Marta; Miljanovic, Milan; Ivic, Vedrana; Viljetic, Barbara; Heffer, Marija] JJ Strossmayer Univ Osijek, Fac Med Osijek, Osijek 31000, Croatia.
   [Blazetic, Senka; Labak, Irena] JJ Strossmayer Univ Osijek, Dept Biol Osijek, Osijek 31000, Croatia.
   [Borbely, Attila; Papp, Zoltan; Fagyas, Miklos] Univ Debrecen, Fac Med, Inst Cardiol, Debrecen, Hungary.
   [Blazekovic, Robert] Univ Hosp Dubrava, Dept Cardiac & Transplantat Surg, Zagreb, Croatia.
   [Vari, Sandor G.] Univ Calif Los Angeles, Cedars Sinai Med Ctr, Int Res & Innovat Management Program, Los Angeles, CA 90048 USA.
C3 University of JJ Strossmayer Osijek; University of JJ Strossmayer
   Osijek; University of Debrecen; University of California System;
   University of California Los Angeles; Cedars Sinai Medical Center
RP Heffer, M (corresponding author), JJ Strossmayer Univ Osijek, Fac Med Osijek, Dept Med Biol & Genet, Josipa Huttlera 4, Osijek 31000, Croatia.
EM mheffer@mefos.hr
RI Blažeković, Robert/HGD-3467-2022; Papp, Zoltán/HDO-3347-2022; Viljetic,
   Barbara/MIT-6402-2025; Fagyas, Miklós/AAQ-1013-2020; Ivić,
   Vedrana/GRS-4202-2022; Heffer, Marija/ABA-4694-2020
OI Ivic, Vedrana/0000-0002-8185-1960; Heffer, Marija/0000-0001-6770-7359;
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FU J. J. Strossmayer University of Osijek
FX Internal grant from J. J. Strossmayer University of Osijek.
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NR 47
TC 11
Z9 11
U1 0
U2 19
PU MEDICINSKA NAKLADA
PI ZAGREB
PA VLASKA 69, HR-10000 ZAGREB, CROATIA
SN 0353-9504
EI 1332-8166
J9 CROAT MED J
JI Croat. Med. J.
PD APR
PY 2015
VL 56
IS 2
BP 104
EP 113
DI 10.3325/cmj.2015.56.104
PG 10
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA CI7LI
UT WOS:000354944500005
PM 25891869
OA Green Submitted, gold, Green Published
DA 2025-06-11
ER

PT J
AU Liu, FG
   Zhang, X
   Zhao, BT
   Tan, XT
   Wang, LF
   Liu, XB
AF Liu, Fuguo
   Zhang, Xin
   Zhao, Beita
   Tan, Xintong
   Wang, Luanfeng
   Liu, Xuebo
TI Role of Food Phytochemicals in the Modulation of Circadian Clocks
SO JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
LA English
DT Article
DE phytochemicals; circadian clocks; oxidative stress; inflammation
   response; metabolic disorder
ID METABOLIC SYNDROME; IMPAIRMENT; PATHWAY
AB The circadian clock is an intrinsic mechanism of biological adaptation to the cyclical changes of the environment. The circadian rhythm disorders affect the life activities of organisms. A variety of phytochemicals (e.g., polyphenols, flavonoids, alkaloids, and melatonin) reportedly can regulate the expression and rhythm of circadian clock genes and stabilize the internal environment. This perspective focuses on the relationship of circadian clock genes with oxidative stress, inflammatory response, and metabolic disorders and emphasizes the regulation of phytochemicals on the circadian clock. Potential mechanisms and applications of supplemental phytochemicals to improve metabolic disorders and circadian rhythm disorders are also discussed.
C1 [Liu, Fuguo; Zhang, Xin; Zhao, Beita; Tan, Xintong; Wang, Luanfeng; Liu, Xuebo] Northwest A&F Univ, Coll Food Sci & Engn, Yangling 712100, Shaanxi, Peoples R China.
C3 Northwest A&F University - China
RP Liu, XB (corresponding author), Northwest A&F Univ, Coll Food Sci & Engn, Yangling 712100, Shaanxi, Peoples R China.
EM xueboliu@aliyun.com
RI Zhao, Beita/AAF-7526-2021; ZHANG, XIN/AAQ-2934-2021; LIU,
   Fuguo/U-2396-2019
OI LIU, Fuguo/0000-0002-1645-0976
FU State Key Research and Development Plan "Modern Food Processing and Food
   Storage and Transportation Technology and Equipment" [2017YFD0400200];
   Chinese Universities Scientific Fund [Z109021714]
FX This work was supported by the State Key Research and Development Plan
   "Modern Food Processing and Food Storage and Transportation Technology
   and Equipment" (2017YFD0400200) and Chinese Universities Scientific Fund
   (Z109021714).
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NR 26
TC 41
Z9 43
U1 10
U2 76
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0021-8561
EI 1520-5118
J9 J AGR FOOD CHEM
JI J. Agric. Food Chem.
PD AUG 14
PY 2019
VL 67
IS 32
BP 8735
EP 8739
DI 10.1021/acs.jafc.9b02263
PG 5
WC Agriculture, Multidisciplinary; Chemistry, Applied; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture; Chemistry; Food Science & Technology
GA IR6QK
UT WOS:000481563600003
PM 31244204
DA 2025-06-11
ER

PT J
AU Lanza, GA
   Parrinello, R
   Figliozzi, S
AF Lanza, Gaetano A.
   Parrinello, Rossella
   Figliozzi, Stefano
TI Management of Microvascular Angina Pectoris
SO AMERICAN JOURNAL OF CARDIOVASCULAR DRUGS
LA English
DT Article
ID CARDIAC SYNDROME-X; NORMAL CORONARY ANGIOGRAMS; SPINAL-CORD STIMULATION;
   CONVERTING ENZYME-INHIBITION; ST-SEGMENT DEPRESSION; TERM-FOLLOW-UP;
   ENHANCED EXTERNAL COUNTERPULSATION; ISCHEMIA SYNDROME EVALUATION;
   EXERCISE-INDUCED ANGINA; CHEST-PAIN
AB Microvascular angina (MVA) is defined as angina pectoris caused by abnormalities of small coronary arteries. In its most typical presentation, MVA is characterized by angina attacks mainly caused by effort, evidence of myocardial ischemia on non-invasive stress tests, but normal coronary arteries at angiography. Patients with stable MVA have excellent long-term prognoses, but often present with persistent and/or worsening of angina symptoms. Treatment of MVA is initially based on standard anti-ischemic drugs (beta-blockers, calcium antagonists, and nitrates), but control of symptoms is often insufficient. In these cases, several additional drugs, with different potential anti-ischemic effects, have been proposed, including ranolazine, ivabradine, angiotensin-converting enzyme (ACE) inhibitors, xanthine derivatives, nicorandil, statins, alpha-blockers and, in perimenopausal women, estrogens. In patients with 'refractory MVA', some further alternative therapies (e.g., spinal cord stimulation, pain-inhibiting substances such as imipramine, rehabilitation programs) have shown favorable results.
C1 [Lanza, Gaetano A.; Parrinello, Rossella; Figliozzi, Stefano] Univ Cattolica Sacro Cuore, Ist Cardiol, Dept Cardiovasc Sci, I-00168 Rome, Italy.
C3 Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli
RP Lanza, GA (corresponding author), Univ Cattolica Sacro Cuore, Ist Cardiol, Dept Cardiovasc Sci, Largo A Gemelli 8, I-00168 Rome, Italy.
EM galanza@alice.it
RI Lanza, Gaetano/AAC-2660-2019; Figliozzi, Stefano/AAU-2182-2020
OI Figliozzi, Stefano/0000-0003-2991-1548
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NR 83
TC 28
Z9 35
U1 0
U2 12
PU ADIS INT LTD
PI NORTHCOTE
PA 5 THE WAREHOUSE WAY, NORTHCOTE 0627, AUCKLAND, NEW ZEALAND
SN 1175-3277
EI 1179-187X
J9 AM J CARDIOVASC DRUG
JI Am. J. Cardiovasc. Drugs
PD FEB
PY 2014
VL 14
IS 1
BP 31
EP 40
DI 10.1007/s40256-013-0052-1
PG 10
WC Cardiac & Cardiovascular Systems; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Pharmacology & Pharmacy
GA 302EW
UT WOS:000330585900003
PM 24174173
DA 2025-06-11
ER

PT J
AU Walia, HK
AF Walia, Harneet K.
TI Beyond heart health: Consequences of obstructive sleep apnea
SO CLEVELAND CLINIC JOURNAL OF MEDICINE
LA English
DT Article
ID POSITIVE AIRWAY PRESSURE; DISORDERED BREATHING TREATMENT;
   BLOOD-PRESSURE; METABOLIC SYNDROME; RESISTANT HYPERTENSION;
   ALZHEIMERS-DISEASE; INSULIN-RESISTANCE; OBESE-PATIENTS; WEIGHT-LOSS;
   RISK-FACTOR
AB Obstructive sleep apnea (OSA) is a serious condition associated with impaired quality of life, depression, drowsy driving and motor vehicle accidents, metabolic disease, and cognitive decline. The mechanisms accounting for OSA and metabolic disease include hypoxia, sleep fragmentation, and systemic inflammation. OSA appears to advance cognitive decline, and the relationship between the 2 conditions may be bidirectional. Treatment of patients with continuous positive air pressure therapy improves many of the impaired outcomes associated with OSA. Greater awareness, screening, and treatment of patients with OSA can reduce the negative consequences associated with OSA.
C1 [Walia, Harneet K.] Case Western Reserve Univ, Cleveland Clin Lerner Coll Med, Med, Cleveland, OH 44106 USA.
   [Walia, Harneet K.] Cleveland Clin, Neurol Inst, Sleep Disorders Ctr, S73,9500 Euclid Ave, Cleveland, OH 44195 USA.
C3 University System of Ohio; Case Western Reserve University; Cleveland
   Clinic Foundation; Cleveland Clinic Foundation
RP Walia, HK (corresponding author), Cleveland Clin, Neurol Inst, Sleep Disorders Ctr, S73,9500 Euclid Ave, Cleveland, OH 44195 USA.
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NR 72
TC 10
Z9 11
U1 0
U2 4
PU CLEVELAND CLINIC
PI CLEVELAND
PA 9500 EUCLID AVE, CLEVELAND, OH 44106 USA
SN 0891-1150
EI 1939-2869
J9 CLEV CLIN J MED
JI Clevel. Clin. J. Med.
PD SEP
PY 2019
VL 86
SU 1
BP 19
EP 25
DI 10.3949/ccjm.86.s1.04
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA IY5VS
UT WOS:000486462800004
PM 31509500
OA gold
DA 2025-06-11
ER

PT J
AU Ziberna, L
   Jenko-Praznikar, Z
   Petelin, A
AF Ziberna, Lovro
   Jenko-Praznikar, Zala
   Petelin, Ana
TI Serum Bilirubin Levels in Overweight and Obese Individuals: The
   Importance of Anti-Inflammatory and Antioxidant Responses
SO ANTIOXIDANTS
LA English
DT Review
DE adipokines; antioxidant; anti-inflammatory; bilirubin; obesity;
   overweight
ID NECROSIS-FACTOR-ALPHA; CONSTITUTIVE ANDROSTANE RECEPTOR;
   PROLIFERATOR-ACTIVATED RECEPTOR; IMPROVES INSULIN SENSITIVITY; HUMAN
   FAT-CELLS; ADIPOSE-TISSUE; OXIDATIVE STRESS; METABOLIC SYNDROME; HEME
   OXYGENASE; CHRONIC INFLAMMATION
AB Obesity is a chronic condition involving low-grade inflammation and increased oxidative stress; thus, obese and overweight people have lower values of serum bilirubin. Essentially, bilirubin is a potent endogenous antioxidant molecule with anti-inflammatory, immunomodulatory, antithrombotic, and endocrine properties. This review paper presents the interplay between obesity-related pathological processes and bilirubin, with a focus on adipose tissue and adipokines. We discuss potential strategies to mildly increase serum bilirubin levels in obese patients as an adjunctive therapeutic approach.
C1 [Ziberna, Lovro] Univ Ljubljana, Fac Med, Inst Pharmacol & Expt Toxicol, SI-1000 Ljubljana, Slovenia.
   [Jenko-Praznikar, Zala; Petelin, Ana] Univ Primorska, Fac Hlth Sci, SI-6310 Izola, Slovenia.
C3 University of Ljubljana; University of Primorska
RP Petelin, A (corresponding author), Univ Primorska, Fac Hlth Sci, SI-6310 Izola, Slovenia.
EM lovro.ziberna@mf.uni-lj.si; zala.praznikar@upr.si; ana.petelin@upr.si
RI Ziberna, Lovro/A-1107-2010; Petelin, Ana/GLV-1610-2022; Jenko Praznikar,
   Zala/KVX-9901-2024
OI Ziberna, Lovro/0000-0002-2840-5208; Petelin, Ana/0000-0002-5557-5974;
   Jenko Praznikar, Zala/0000-0002-5217-8754
FU Slovenian Research Agency [J3 8209, P1 0386, P3 0067]; University of
   Primorska, Faculty of Health Sciences
FX The authors acknowledge that this work was financially supported by the
   Slovenian Research Agency under research project J3 8209 (Bilirubin as a
   Protective Factor Against Chronic Degenerative Disease: Biomarker and
   Potential for Pharmacological Modulation) and research programs P1 0386
   and P3 0067. Additionally, we were financially supported by the
   University of Primorska, Faculty of Health Sciences, for the project
   entitled A Multidisciplinary Approach in the Treatment of Obesity.
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   Zuperl S, 2011, ANAL CHIM ACTA, V705, P322, DOI 10.1016/j.aca.2011.07.004
NR 132
TC 30
Z9 30
U1 1
U2 21
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD SEP
PY 2021
VL 10
IS 9
AR 1352
DI 10.3390/antiox10091352
PG 16
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA UV2PM
UT WOS:000699327300001
PM 34572984
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Hadziabdic, MO
   Bozikov, V
   Pavic, E
   Romic, Z
AF Hadziabdic, Maja Ortner
   Bozikov, Velimir
   Pavic, Eva
   Romic, Zeljko
TI The Antioxidative Protecting Role of the Mediterranean Diet
SO COLLEGIUM ANTROPOLOGICUM
LA English
DT Article
DE Mediterranean diet (MD); oxidative stress (OS); antioxidative property;
   oxidative stress biomarkers
ID CORONARY-HEART-DISEASE; DENSITY-LIPOPROTEIN OXIDATION; VIRGIN OLIVE OIL;
   ENDOTHELIAL FUNCTION; PHENOLIC-COMPOUNDS; RISK-FACTORS; METABOLIC
   SYNDROME; DNA-DAMAGE; STRESS; CAPACITY
AB Recent meta-analysis shows that adherence to a Mediterranean diet (MD) can significantly decrease the risk of overall mortality, mortality from cardiovascular diseases, as well as incidence of mortality from cancer, and incidence of Parkinson's and Alzheimer's disease. All of these diseases could be linked to oxidative stress (OS) as antioxidative effect of MD is getting more attention nowadays. Although a lot of research has been done in this area and it suggests antioxidative protective role of MD, the presented evidence is still inconclusive. The aim of this paper is to review studies investigating the effect of MD on OS, as well as to identify the areas for further research.
C1 [Hadziabdic, Maja Ortner] Univ Zagreb, Fac Pharm & Biochem, Ctr Appl Pharm, Zagreb 10000, Croatia.
   [Bozikov, Velimir] Univ Zagreb, Dubrava Univ Hosp, Dept Endocrinol Diabet & Metab Disorders, Zagreb 10000, Croatia.
   [Pavic, Eva] Univ Zagreb, Zagreb Univ Hosp Ctr, Dept Nutr, Zagreb 10000, Croatia.
   [Romic, Zeljko] Univ Zagreb, Dubrava Univ Hosp, Clin Dept Lab Diagnost, Zagreb 10000, Croatia.
C3 University of Zagreb; University of Zagreb; University of Zagreb;
   UNIVERSITY ZAGREB HOSPITAL; University of Zagreb
RP Hadziabdic, MO (corresponding author), Univ Zagreb, Fac Pharm & Biochem, Ctr Appl Pharm, Ante Kovacica 1, Zagreb 10000, Croatia.
EM mortner@pharma.hr
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NR 68
TC 16
Z9 20
U1 2
U2 35
PU COLLEGIUM ANTROPOLOGICUM
PI ZAGREB
PA INST ANTHROPOLOGICAL RESEARCH, GAJEVA 32, PO BOX 290, HR-10000 ZAGREB,
   CROATIA
SN 0350-6134
J9 COLLEGIUM ANTROPOL
JI Coll. Anthropol.
PD DEC
PY 2012
VL 36
IS 4
BP 1427
EP 1434
PG 8
WC Anthropology
WE Social Science Citation Index (SSCI)
SC Anthropology
GA 076ZY
UT WOS:000313998900050
PM 23390845
DA 2025-06-11
ER

PT J
AU Kawamoto, R
   Imamura, T
   Kawabata, K
   Date, H
   Ishikawa, T
   Maeno, M
   Nagoshi, T
   Fujiura, Y
   Matsuyama, A
   Matsuo, T
   Koiwaya, Y
   Eto, T
AF Kawamoto, R
   Imamura, T
   Kawabata, K
   Date, H
   Ishikawa, T
   Maeno, M
   Nagoshi, T
   Fujiura, Y
   Matsuyama, A
   Matsuo, T
   Koiwaya, Y
   Eto, T
TI Microvascular angina in a patient with aortic stenosis
SO JAPANESE CIRCULATION JOURNAL-ENGLISH EDITION
LA English
DT Article
DE aortic stenosis; coronary flow reserve; Doppler flow wire; microvascular
   angina; papaverine
ID NORMAL CORONARY-ARTERIES; VENTRICULAR-FUNCTION; CHEST PAIN; SYNDROME-X;
   RESERVE; PECTORIS; MECHANISMS; HYPERTROPHY; PAPAVERINE; METABOLISM
AB A 39-year-old woman had exercise-induced ST segment depression associated with chest pain. Cardiac evaluation revealed moderate aortic stenosis (AS), related to the bicuspid valves, with an aortic mean pressure gradient of 22 mmHg, a calculated aortic valve area of 1.3 cm(2) and normal left ventricular (LV) peak systolic and end-diastolic pressures, but no LV hypertrophy, resulting in normal LV wall stress. Although the coronary arteries were angiographically normal, rapid atrial pacing and an intracoronary papaverine injection revealed a significantly decreased coronary flow reserve (CFR), which may have played an important role in the pathogenesis of angina pectoris in this patient. Though the CFR is usually decreased in patients with AS, as well as in microvascular angina, in this particular case, it appeared to have decreased as a consequence of microvascular dysfunction rather than of AS-related mechanisms.
C1 Miyazaki Med Coll, Dept Internal Med 1, Miyazaki 8891692, Japan.
C3 University of Miyazaki
RP Miyazaki Med Coll, Dept Internal Med 1, 5200 Kihara, Miyazaki 8891692, Japan.
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NR 22
TC 9
Z9 10
U1 0
U2 0
PU BLACKWELL PUBLISHING ASIA
PI CARLTON
PA 54 UNIVERSITY ST, P O BOX 378, CARLTON, VICTORIA 3053, AUSTRALIA
SN 0047-1828
J9 JPN CIRC J
JI Jpn. Circ. J.-Engl. Ed.
PD SEP
PY 2001
VL 65
IS 9
BP 839
EP 841
DI 10.1253/jcj.65.839
PG 3
WC History & Philosophy Of Science; Social Sciences, Biomedical; Peripheral
   Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC History & Philosophy of Science; Biomedical Social Sciences;
   Cardiovascular System & Cardiology
GA 467DC
UT WOS:000170684400016
PM 11548887
OA Bronze
DA 2025-06-11
ER

PT J
AU Girijala, RL
   Sohrabji, F
   Bush, RL
AF Girijala, Raghavendra L.
   Sohrabji, Farida
   Bush, Ruth L.
TI Sex differences in stroke: Review of current knowledge and evidence
SO VASCULAR MEDICINE
LA English
DT Review
DE sex differences; stroke; women
ID TISSUE-PLASMINOGEN ACTIVATOR; UNITED-STATES REGISTRY; ACUTE
   ISCHEMIC-STROKE; FIBROMUSCULAR DYSPLASIA; METABOLIC SYNDROME;
   CARDIOVASCULAR-DISEASE; POSTSTROKE DEPRESSION; CLINICAL PRESENTATION;
   GENDER-DIFFERENCES; MEDICAL-CARE
AB Stroke is a leading cause of death among women in the United States, and women are more affected by stroke than men. With women living longer than men, women experience not only a higher incidence of stroke but also more negative outcomes. Despite its lethal impact and high morbidity rate, the road from innovative bench research to improved clinical outcomes has been slow. This review explores the differential physiology, epidemiology, and clinical presentation of stroke between men and women, as well as the current status of laboratory and clinical data.
C1 [Girijala, Raghavendra L.; Sohrabji, Farida] Texas A&M Univ, Coll Med, College Stn, TX 77843 USA.
   [Bush, Ruth L.] Baylor Coll Med, Houston, TX 77030 USA.
C3 Texas A&M University System; Texas A&M University College Station;
   Baylor College of Medicine
RP Bush, RL (corresponding author), Baylor Coll Med, Ctr Innovat Qual Effectiveness & Safety IQuESt, Michael E DeBakey Vet Affairs Med Ctr, 2002 Holcombe Blvd 152, Houston, TX 77030 USA.
EM rbush@bcm.edu
OI Sohrabji, Farida/0000-0002-6960-3411
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NR 110
TC 102
Z9 112
U1 0
U2 12
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1358-863X
EI 1477-0377
J9 VASC MED
JI Vasc. Med.
PD APR
PY 2017
VL 22
IS 2
BP 135
EP 145
DI 10.1177/1358863X16668263
PG 11
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA ET2QJ
UT WOS:000400118900009
PM 27815349
DA 2025-06-11
ER

PT J
AU Derme, M
   Briante, M
   Ceccanti, M
   Giannini, G
   Vitali, M
   Messina, MP
   Piccioni, MG
   Mattia, A
   Nicotera, S
   Crognale, A
AF Derme, Martina
   Briante, Martina
   Ceccanti, Mauro
   Giannini, Giuseppe
   Vitali, Mario
   Messina, Marisa Patrizia
   Piccioni, Maria Grazia
   Mattia, Alessandro
   Nicotera, Simona
   Crognale, Alba
TI Prenatal Alcohol Exposure and Metabolic Disorders in Pediatrics: The
   Role of the Oxidative Stress-A Review of the Literature
SO CHILDREN-BASEL
LA English
DT Review
DE fetal alcohol spectrum disorder (FASD); prenatal alcohol exposure (PAE);
   oxidative stress; metabolic disorders
ID CONGENITAL HEART-DISEASE; SPECTRUM DISORDERS; MEDITERRANEAN DIET; GROWTH
   RESTRICTION; ETHYL GLUCURONIDE; ANIMAL-MODELS; LIVER-DISEASE; HUMAN
   BRAIN; ETHANOL; CHILDREN
AB Prenatal alcohol exposure is responsible for increasing chronic disease risk in later life, including obesity and metabolic syndrome. Alcohol drinking may compromise endogenous antioxidant capacity, causing an increase in free radicals and reactive oxygen species in the newborn. Excessive reactive oxygen species could attack the cellular proteins, lipids, and nucleic acids, leading to cellular dysfunction. Moreover, oxidative stress could play a crucial role in the altered synthesis and release of neurotrophins and progressive mitochondrial modifications with uncontrolled apoptosis. This narrative review aims to underline the important role of alcohol abuse in oxidative stress events and consequent metabolic and neurocognitive impairments in children exposed to alcohol during gestational life.
C1 [Derme, Martina; Briante, Martina; Messina, Marisa Patrizia; Piccioni, Maria Grazia; Crognale, Alba] Sapienza Univ Rome, Dept Maternal Infantile & Urol Sci, Viale Policlin 155, I-00161 Rome, Italy.
   [Ceccanti, Mauro] Italian Soc Treatment Alcoholism & Its Complicat S, I-00185 Rome, Italy.
   [Giannini, Giuseppe] Sapienza Univ Rome, Dept Mol Med, Viale Regina Elena 291, I-00161 Rome, Italy.
   [Vitali, Mario] ASUR Marche, AV4, I-60122 Ancona, Italy.
   [Mattia, Alessandro; Nicotera, Simona] Minist Interno, Dipartimento Pubbl Sicurezza, Ctr di Ric & Lab Tossicol Forense, Direzione Cent Sanita, I-00185 Rome, Italy.
C3 Sapienza University Rome; Sapienza University Rome
RP Ceccanti, M (corresponding author), Italian Soc Treatment Alcoholism & Its Complicat S, I-00185 Rome, Italy.
EM martina.derme@uniroma1.it; mauro.ceccanti@uniroma1.it;
   mariagrazia.piccioni@uniroma1.it; alba.crognale@uniroma1.it
RI Derme, Martina/IRZ-4288-2023; Ceccanti, Mauro/MVW-1162-2025; Porpora,
   Maria Grazia/F-6745-2011; Messina, Marisa/O-6808-2018
OI Mattia, Alessandro/0000-0002-9051-4018; DERME,
   MARTINA/0000-0003-2500-4166; Crognale, Alba/0009-0007-4860-251X
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NR 130
TC 4
Z9 4
U1 1
U2 1
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2227-9067
J9 CHILDREN-BASEL
JI Children-Basel
PD MAR
PY 2024
VL 11
IS 3
AR 269
DI 10.3390/children11030269
PG 14
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA MC9Y7
UT WOS:001191557600001
PM 38539304
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Lee, MS
AF Lee, Myung-Shik
TI Role of islet β cell autophagy in the pathogenesis of diabetes
SO TRENDS IN ENDOCRINOLOGY AND METABOLISM
LA English
DT Review
DE beta cell; autophagy; obesity; ER stress; islet amyloid
ID ENDOPLASMIC-RETICULUM STRESS; AMYLOID POLYPEPTIDE TOXICITY; REGULATED
   AUTOPHAGY; NLRP3 INFLAMMASOME; OXIDATIVE STRESS; PROTECTIVE ROLE; ER
   STRESS; RAT-LIVER; INSULIN; ACTIVATION
AB While the role of autophagy in the physiology of endocrine organs and the development of metabolic disorders or diabetes has been investigated, the relationship between the pancreatic islet and autophagy has not been explored extensively. In this review, studies on the possible involvement of dysregulated autophagy in the pathogenesis of metabolic syndrome and diabetes will be summarized with an emphasis on the autophagic process in pancreatic islet cells. Novel findings regarding the role of autophagy in human beta cell pathology and the development of type 2 diabetes (T2D) characterized by islet amyloid deposition will be discussed. Careful design of agents enhancing autophagic activity in beta cells might serve as a novel approach towards therapeutics for the treatment of diabetes.
C1 Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Med, Seoul 135710, South Korea.
C3 Sungkyunkwan University (SKKU); Samsung Medical Center
RP Lee, MS (corresponding author), Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Med, Seoul 135710, South Korea.
EM mslee0923@skku.edu
RI Lee, Myung/C-9606-2011
FU Global Research Laboratory Grant from the National Research Foundation
   of Korea [2010-00347]; National Research Foundation of Korea
   [2014M3A9D8034459]
FX This study was supported by a Global Research Laboratory Grant
   (2010-00347) from the National Research Foundation of Korea. M.S.L. is
   the recipient of the BioDevelopment Grant (2014M3A9D8034459) from the
   National Research Foundation of Korea.
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NR 98
TC 78
Z9 85
U1 1
U2 35
PU ELSEVIER SCIENCE LONDON
PI LONDON
PA 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND
SN 1043-2760
EI 1879-3061
J9 TRENDS ENDOCRIN MET
JI Trends Endocrinol. Metab.
PD DEC
PY 2014
VL 25
IS 12
BP 620
EP 627
DI 10.1016/j.tem.2014.08.005
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA AX8DL
UT WOS:000347140500002
PM 25242548
DA 2025-06-11
ER

PT J
AU Ron, D
   Harding, HP
AF Ron, David
   Harding, Heather P.
TI Protein-Folding Homeostasis in the Endoplasmic Reticulum and Nutritional
   Regulation
SO COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY
LA English
DT Article
ID INTEGRATED STRESS-RESPONSE; INDUCED GENE-EXPRESSION; BETA-CELL
   DYSFUNCTION; ER STRESS; SELECTIVE-INHIBITION; EIF2-ALPHA
   DEPHOSPHORYLATION; TRANSLATIONAL REGULATION; GLUCOSE-HOMEOSTASIS;
   MESSENGER-RNAS; ALPHA-SUBUNIT
AB The flux of newly synthesized proteins entering the endoplasmic reticulum (ER) is under negative regulation by the ER-localized PKR-like ER kinase (PERK). PERK is activated by unfolded protein stress in the ER lumen and inhibits new protein synthesis by the phosphorylation of translation initiation factor eIF2 alpha. This homeostatic mechanism, shared by all animal cells, has proven to be especially important to the well-being of professional secretory cells, notably the endocrine pancreas. PERK, its downstream effectors, and the allied branches of the unfolded protein response intersect broadly with signaling pathways that regulate nutrient assimilation, and ER stress and the response to it have been implicated in the development of the metabolic syndrome accompanying obesity in mammals. Here we review our current understanding of the cell biology underlying these relationships.
C1 [Ron, David] Univ Cambridge, Metab Res Labs, Cambridge CB2 0QQ, England.
   Addenbrookes Hosp, NIHR Cambridge Biomed Res Ctr, Cambridge CB2 0QQ, England.
C3 University of Cambridge; Cambridge University Hospitals NHS Foundation
   Trust; Addenbrooke's Hospital; University of Cambridge
RP Ron, D (corresponding author), Univ Cambridge, Metab Res Labs, Cambridge CB2 0QQ, England.
EM dr360@medschl.cam.ac.uk
OI Harding, Heather P/0000-0002-7359-7974; Ron, David/0000-0002-3014-5636
FU Wellcome Trust; EU [277713]; NIH [DK47119]
FX This work is supported by a Wellcome Trust Principal Research Fellowship
   to D.R. and by EU FP7 BetaBat grant 277713 and by NIH grant DK47119.
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NR 81
TC 78
Z9 85
U1 0
U2 28
PU COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
PI COLD SPRING HARBOR
PA 1 BUNGTOWN RD, COLD SPRING HARBOR, NY 11724 USA
SN 1943-0264
J9 CSH PERSPECT BIOL
JI Cold Spring Harbor Perspect. Biol.
PD DEC
PY 2012
VL 4
IS 12
AR a013177
DI 10.1101/cshperspect.a013177
PG 13
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA 054SL
UT WOS:000312363400017
PM 23209157
OA Green Published, Bronze
DA 2025-06-11
ER

PT S
AU Qi, L
   Yang, L
   Chen, H
AF Qi, Ling
   Yang, Liu
   Chen, Hui
BE Conn, PM
TI DETECTING AND QUANTITATING PHYSIOLOGICAL ENDOPLASMIC RETICULUM STRESS
SO METHODS IN ENZYMOLOGY: UNFOLDED PROTEIN RESPONSE AND CELLULAR STRESS,
   VOL 490, PT B
SE Methods in Enzymology
LA English
DT Review; Book Chapter
ID UNFOLDED PROTEIN RESPONSE; GLUCOSE-HOMEOSTASIS; TRANSLATIONAL CONTROL;
   TRANSCRIPTION FACTOR; BETA-CELLS; PHOSPHORYLATION; PATHWAY;
   OLIGOMERIZATION; MAINTAINS; DISTINCT
AB Unfolded protein response (UPR) is a key cellular defense mechanism associated with many human "conformational" diseases, including heart diseases, neurodegeneration, and metabolic syndrome. One of the major obstacles that have hindered our further understanding of physiological UPR and its future therapeutic potential is our inability to detect and quantitate ER stress and UPR activation under physiological and pathological conditions, where ER stress is perceivably very mild. Here, we describe a Phos-tag-based Western blot approach that allows for direct visualization and quantitative assessment of mild ER stress and UPR signaling, directly at the levels of UPR sensors, in various in vivo conditions. This method will likely pave the foundation for future studies on physiological UPR, aid in the diagnosis of ER-associated diseases, and facilitate therapeutic strategies targeting UPR in vivo.
C1 [Qi, Ling; Chen, Hui] Cornell Univ, Div Nutr Sci, Ithaca, NY 14853 USA.
   [Qi, Ling; Yang, Liu] Cornell Univ, Grad Program Biochem Mol & Cell Biol, Ithaca, NY USA.
C3 Cornell University; Cornell University
RP Qi, L (corresponding author), Cornell Univ, Div Nutr Sci, Ithaca, NY 14853 USA.
RI Qi, Ling/KHE-3068-2024
OI Qi, Ling/0000-0001-8229-0184
FU NIDDK NIH HHS [R01 DK082582, R01DK082582] Funding Source: Medline
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NR 24
TC 36
Z9 43
U1 0
U2 4
PU ELSEVIER ACADEMIC PRESS INC
PI SAN DIEGO
PA 525 B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0076-6879
BN 978-0-12-385114-7
J9 METHOD ENZYMOL
JI Methods Enzymol.
PY 2011
VL 490
BP 137
EP 146
DI 10.1016/B978-0-12-385114-7.00008-8
PG 10
WC Biochemical Research Methods; Biochemistry & Molecular Biology
WE Book Citation Index – Science (BKCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA BTP02
UT WOS:000287674900008
PM 21266248
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Manhem, K
   Ahlm, H
   Dellborg, M
   Milsom, I
AF Manhem, K
   Ahlm, H
   Dellborg, M
   Milsom, I
TI Acute effects of transdermal estrogen in postmenopausal women with
   coronary artery disease - Using a clinically relevant estrogen dose and
   concurrent antianginal therapy
SO CARDIOLOGY
LA English
DT Article
DE coronary heart disease; postmenopausal women; estrogen
ID DENSITY-LIPOPROTEIN OXIDATION; REPLACEMENT THERAPY; HORMONE REPLACEMENT;
   MYOCARDIAL-ISCHEMIA; SYNDROME-X; ANGINA; PERFORMANCE; ESTRADIOL;
   CHANNELS
AB In the present study the acute anti-ischemic effect of clinically relevant doses of transdermal estradiol during concurrent antianginal therapy was investigated in 14 postmenopausal women with stable coronary artery disease, Plasma estradiol was significantly increased, but no significant effects on time to angina, time to 1 mm S-T depression, total exercise time, maximum rate-pressure product, maximum S-T depression or maximum workload were found, However, resting diastolic blood pressure was significantly decreased due to estrogen, Copyright (C) 2001 S. Karger AG, Basel .
C1 Sahlgrens Univ Hosp, Dept Med, Clin Expt Res Lab, Univ Gothenburg, S-41685 Gothenburg, Sweden.
   Sahlgrens Univ Hosp, Dept Obstet & Gynecol, Univ Gothenburg, S-41345 Gothenburg, Sweden.
C3 Sahlgrenska University Hospital; University of Gothenburg; University of
   Gothenburg; Sahlgrenska University Hospital
RP Manhem, K (corresponding author), Sahlgrens Univ Hosp, Dept Med, Clin Expt Res Lab, Univ Gothenburg, S-41685 Gothenburg, Sweden.
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NR 31
TC 0
Z9 0
U1 0
U2 0
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0008-6312
J9 CARDIOLOGY
JI Cardiology
PY 2000
VL 94
IS 2
BP 86
EP 90
DI 10.1159/000047297
PG 5
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 395EU
UT WOS:000166567600003
PM 11173778
DA 2025-06-11
ER

PT J
AU Patel, S
   Pangarkar, A
   Mahajan, S
   Majumdar, A
AF Patel, Shivangi
   Pangarkar, Arnika
   Mahajan, Sakshi
   Majumdar, Anuradha
TI Therapeutic potential of endoplasmic reticulum stress inhibitors in the
   treatment of diabetic peripheral neuropathy
SO METABOLIC BRAIN DISEASE
LA English
DT Review
DE Unfolded Protein Response; Diabetic peripheral neuropathy (DPN);
   Hyperalgesia; Allodynia; ER stress inhibitors
ID PROTECTS PC12 CELLS; ER STRESS; CALCIUM HOMEOSTASIS; OXIDATIVE STRESS;
   MOUSE MODEL; BETA-CELLS; APOPTOSIS; INSULIN; DEATH; 4-PHENYLBUTYRATE
AB Endoplasmic stress response, the unfolded protein response (UPR), is a homeostatic signaling pathway comprising transmembrane sensors that get activated upon alterations in ER luminal environment. Studies suggest a relation between activated UPR pathways and several disease states such as Parkinson, Alzheimer, inflammatory bowel disease, tumor growth, and metabolic syndrome. Diabetic peripheral neuropathy (DPN), a common microvascular complication of diabetes-related chronic hyperglycemia, causes chronic pain, loss of sensation, foot ulcers, amputations, allodynia, hyperalgesia, paresthesia, and spontaneous pain. Factors like disrupted calcium signaling, dyslipidemia, hyperglycemia, inflammation, insulin signaling, and oxidative stress disturb the UPR sensor levels manifesting as DPN. We discuss new effective therapeutic alternatives for DPN that can be developed by targeting UPR pathways like synthetic ER stress inhibitors like 4-PhenylButyric acid (4-PBA), Sephin 1, Salubrinal and natural ER stress inhibitors like Tauroursodeoxycholic acid (TUDCA), Cordycepin, Proanthocyanidins, Crocin, Purple Rice extract and cyanidin and Caffeic Acid Phenethyl Ester (CAPE).
C1 [Patel, Shivangi; Pangarkar, Arnika; Mahajan, Sakshi; Majumdar, Anuradha] Bombay Coll Pharm, Dept Pharmacol, Mumbai 400098, India.
RP Majumdar, A (corresponding author), Bombay Coll Pharm, Dept Pharmacol, Mumbai 400098, India.
EM anuradha.majumdar@gmail.com
OI Patel, Shivangi/0009-0006-8529-6155; Mahajan, Sakshi/0009-0000-6179-2564
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NR 91
TC 19
Z9 20
U1 3
U2 23
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0885-7490
EI 1573-7365
J9 METAB BRAIN DIS
JI Metab. Brain Dis.
PD AUG
PY 2023
VL 38
IS 6
BP 1841
EP 1856
DI 10.1007/s11011-023-01239-x
EA JUN 2023
PG 16
WC Endocrinology & Metabolism; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology
GA L6GJ0
UT WOS:001003198800001
PM 37289403
DA 2025-06-11
ER

PT J
AU Shimosawa, T
   Fujita, T
AF Shimosawa, T
   Fujita, T
TI Adrenomedullin as a potent antioxidative and antiatherosclerotic
   substance
SO DRUG NEWS & PERSPECTIVES
LA English
DT Article
ID NEWLY IDENTIFIED PEPTIDE; INSULIN-RESISTANCE; MICE LACKING; SECRETION;
   STRESS; GENE; ABNORMALITIES; RECEPTORS; PRESSURE; INJURY
AB Adrenomedullin was originally discovered as a vasodilative peptide, but recent studies have revealed its pleiotropic effects. Among these studies, the antioxidative properties of adrenomedullin were observed in adrenomedullin knockout mice. Through its antioxidative. effect, adrenomedullin can protect organs from damage induced by high blood pressure, ischemia and aging. This indicates that antioxidants that can inhibit reactive oxygen species production but do not have a scavenging effect could be a new effective therapeutic target for organ protection in hypertension as well as metabolic syndrome, in which higher oxidative stress plays a pivotal role. (c) 2005 Prous Science. All rights reserved.
C1 Univ Tokyo, Fac Med, Dept Internal Med, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1138655, Japan.
C3 University of Tokyo
RP Univ Tokyo, Fac Med, Dept Internal Med, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1138655, Japan.
EM fujita-dis@h.u-tokyo.ac.jp
RI Shimosawa, Tatsuo/A-2920-2015
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NR 54
TC 18
Z9 21
U1 0
U2 1
PU PROUS SCIENCE, SAU-THOMSON REUTERS
PI BARCELONA
PA 398 PROVENCA, 08025 BARCELONA, SPAIN
SN 0214-0934
EI 2013-0139
J9 DRUG NEWS PERSPECT
JI Drug News Perspect.
PD APR
PY 2005
VL 18
IS 3
BP 185
EP 189
DI 10.1358/dnp.2005.18.3.892764
PG 5
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 928AQ
UT WOS:000229243900006
PM 15915220
DA 2025-06-11
ER

PT J
AU Jeon, SW
   Chang, Y
   Lim, SW
   Cho, J
   Kim, HN
   Kim, KB
   Kim, J
   Kim, YH
   Shin, DW
   Oh, KS
   Shin, YC
   Ryu, S
AF Jeon, Sang Won
   Chang, Yoosoo
   Lim, Se-Won
   Cho, Juhee
   Kim, Han-Na
   Kim, Kyoung-Beom
   Kim, Jinseok
   Kim, Young Hwan
   Shin, Dong-Won
   Oh, Kang-Seob
   Shin, Young-Chul
   Ryu, Seungho
TI Bidirectional association between blood pressure and depressive symptoms
   in young and middle-age adults: A cohort study
SO EPIDEMIOLOGY AND PSYCHIATRIC SCIENCES
LA English
DT Article
DE Bidirectional association; blood pressure; cohort study; depression;
   depressive symptoms; hypertension; hypotension
ID EPIDEMIOLOGIC CATCHMENT-AREA; CES-D SCALE; METABOLIC SYNDROME;
   NEUROPEPTIDE-Y; HYPERTENSION INCIDENCE; ANXIETY; RISK; PATHOPHYSIOLOGY;
   METAANALYSIS; HYPOTHESIS
AB Aims To evaluate the bidirectional relationship between blood pressure (BP) and depressive symptoms using a large prospective cohort study. Methods Prospective cohort study was performed in 276 244 adults who participated in a regular health check-up and were followed annually or biennially for up to 5.9 years. BP levels were categorised according to the 2017 American College of Cardiology and American Heart Association hypertension guidelines. Depressive symptoms were assessed using Centre for Epidemiologic Studies-Depression (CESD) questionnaire and a cut-off score of >= 25 was regarded as case-level depressive symptoms. Results During 672 603.3 person-years of follow-up, 5222 participants developed case-level depressive symptoms. The multivariable-adjusted hazard ratios (HRs) [95% confidence interval (CI)] for incident case-level depressive symptoms comparing hypotension, elevated BP, hypertension stage 1 and hypertension stage 2 to normal BP were 1.07 (0.99-1.16), 0.93 (0.82-1.05), 0.89 (0.81-0.97) and 0.81 (0.62-1.06), respectively (pfor trend <0.001). During 583 615.3 person-years of follow-up, 27 787 participants developed hypertension. The multivariable-adjusted HRs (95% CI) for incident hypertension comparing CESD 16-24 and > 25 to CESD < 16 were 1.05 (1.01-1.11) and 1.12 (1.03-1.20), respectively (pfor trend <0.001) and in the time-dependent models, corresponding HRs (95% CI) were 1.12 (1.02-1.24) and 1.29 (1.10-1.50), respectively (pfor trend <0.001). Conclusions In this large cohort study of young and middle-aged individuals, higher BP levels were independently associated with a decreased risk for developing case-level depressive symptoms and depressive symptoms were also associated with incident hypertension. Further studies are required to elucidate the mechanisms underlying the bidirectional association between BP levels and incident depression.
C1 [Jeon, Sang Won; Lim, Se-Won; Shin, Dong-Won; Oh, Kang-Seob; Shin, Young-Chul] Sungkyunkwan Univ, Kangbuk Samsung Hosp, Dept Psychiat, Sch Med, Seoul, South Korea.
   [Chang, Yoosoo; Cho, Juhee; Kim, Kyoung-Beom; Ryu, Seungho] Kangbuk Samsung Hosp, Ctr Cohort Study, Total Healthcare Ctr, Seoul, South Korea.
   [Chang, Yoosoo; Ryu, Seungho] Sungkyunkwan Univ, Kangbuk Samsung Hosp, Dept Occupat & Environm Med, Sch Med, Seoul, South Korea.
   [Chang, Yoosoo; Cho, Juhee; Kim, Han-Na; Ryu, Seungho] Sungkyunkwan Univ, Dept Clin Res Design & Evaluat, SAIHST, Seoul, South Korea.
   [Lim, Se-Won; Shin, Young-Chul] Kangbuk Samsung Hosp, Workpl Mental Hlth Inst, Seoul, South Korea.
   [Kim, Han-Na] Sungkyunkwan Univ, Kangbuk Samsung Hosp, Med Res Inst, Sch Med, Seoul, South Korea.
   [Kim, Jinseok] Seoul Womens Univ, Dept Social Welf, Seoul, South Korea.
   [Kim, Young Hwan] Sungkyunkwan Univ, Kangbuk Samsung Hosp, Dept Nucl Med, Sch Med, Seoul, South Korea.
C3 Sungkyunkwan University (SKKU); Samsung Medical Center; Sungkyunkwan
   University (SKKU); Samsung Medical Center; Sungkyunkwan University
   (SKKU); Samsung Medical Center; Sungkyunkwan University (SKKU);
   Sungkyunkwan University (SKKU); Samsung Medical Center; Sungkyunkwan
   University (SKKU); Samsung Medical Center; Seoul Women's University;
   Sungkyunkwan University (SKKU); Samsung Medical Center
RP Ryu, S (corresponding author), Kangbuk Samsung Hosp, Ctr Cohort Study, Total Healthcare Ctr, Seoul, South Korea.; Ryu, S (corresponding author), Sungkyunkwan Univ, Kangbuk Samsung Hosp, Dept Occupat & Environm Med, Sch Med, Seoul, South Korea.; Ryu, S (corresponding author), Sungkyunkwan Univ, Dept Clin Res Design & Evaluat, SAIHST, Seoul, South Korea.
EM sh703.yoo@gmail.com
RI Kim, Kisook/GQB-2543-2022; Kim, Sunuk/KJM-5211-2024; Shin,
   Dong/F-5366-2010; Cho, Juhee/ABD-2280-2021
OI Chang, Yoosoo/0000-0002-6945-9050; Ryu, Seungho/0000-0002-3927-8646
FU Byung-yoon Lee Scholarship Association
FX We dedicate this paper to the spirit of the departed, Professor Se-Won
   Lim. This research was supported by the Byung-yoon Lee Scholarship
   Association.
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NR 51
TC 25
Z9 27
U1 0
U2 3
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 2045-7960
EI 2045-7979
J9 EPIDEMIOL PSYCH SCI
JI Epidemiol. Psychiatr. Sci.
PY 2020
VL 29
AR e142
DI 10.1017/S2045796020000542
PG 9
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA MK1HQ
UT WOS:000548537800001
PM 32665058
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Stankovic, Z
   Jasovic-Gasic, M
   Zamaklar, M
AF Stankovic, Zana
   Jasovic-Gasic, Miroslava
   Zamaklar, Miroslava
TI PSYCHO-SOCIAL AND CLINICAL VARIABLES ASSOCIATED WITH DEPRESSION IN
   PATIENTS WITH TYPE 2 DIABETES
SO PSYCHIATRIA DANUBINA
LA English
DT Article
DE depression; type 2 diabetes; comorbidity; risk factors; neuropathy;
   diabetes related distress
ID QUALITY-OF-LIFE; CO-MORBID DEPRESSION; GLYCEMIC CONTROL; METABOLIC
   SYNDROME; EUROPEAN DEPRESSION; COMORBID DEPRESSION; SYMPTOMS;
   PREVALENCE; DISORDERS; RISK
AB Background: Type 2 diabetes (T2DM,) doubles the odds of comorbid depression. Depression is a strong predictor of developing T2DM The aim of the study was to compare depressed patients with T2DM to non-depressed ones with respect to demographic, psycho-social, clinical, anthropometric and metabolic characteristics; to examine the relationship between glycemic control and depression severity in depressed patients; to estimate the risk factors of depression.
   Subjects and Methods: A group of depressed diabetic patients comprising those with a Major depressive episode, first or repeated (ICD-10; 1992) and endocrinologist-diagnosed T2DM, duration >= 5 years on oral, insulin therapy or both (N=46) and non-depressed ones (N=44) (90 in total) of both genders (< 65 years) were included in this cross-sectional study. Laboratory and non-laboratory measures were performed.. The patient Health Questionnaire (PHQ-9) and a structured interview (MINI) were used to establish diagnosis, while the Beck Depression Inventory (BDI; cut off >= 16) was used to assess the severity of depression. Scaling of Life Events (SLE) for self-assessment of life events and Problem in Areas in Diabetes (PAID) for self-assessment of diabetes distress were also performed.
   Results: Statistically significant higher rates of psychiatric heredity, neuropathy, higher level of diabetes related distress and a greater number of life events in depressed patients compared to non-depressed ones were found There was a statistically significant positive correlation between BDI somatic subscore and the HbAlc level (r=0.343; p=0.020). The level of diabetes related distress (OR=1.084; p=0.000), total number of life events (OR=4.528; p=0.001) and neuropathy (OR=8.699; p=0.039) were statistically significant predictors of depression using logistic regression.
   Conclusions: The results obtained showed that depression in diabetic patients was predicted by both psychological (diabetes related distress, life events) and disease-specific variables (neuropathy). The severity of self-reported somatic depressive symptoms significantly correlated with the HbAlc level in depressed diabetic patients.
C1 [Stankovic, Zana; Jasovic-Gasic, Miroslava] Univ Belgrade, Psychiat Clin, Clin Ctr Serbia, Belgrade 11000, Serbia.
   [Zamaklar, Miroslava] Univ Belgrade, Inst Endocrinol Diabet & Dis Metab, Belgrade 11000, Serbia.
   [Jasovic-Gasic, Miroslava; Zamaklar, Miroslava] Univ Belgrade, Sch Med, Belgrade 11000, Serbia.
C3 University of Belgrade; Clinical Centre of Serbia; University of
   Belgrade; University of Belgrade
RP Stankovic, Z (corresponding author), Univ Belgrade, Psychiat Clin, Clin Ctr Serbia, Pasterova 2, Belgrade 11000, Serbia.
EM stankovic.zana@gmail.com
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U1 0
U2 8
PU MEDICINSKA NAKLADA
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PA VLASKA 69, HR-10000 ZAGREB, CROATIA
SN 0353-5053
J9 PSYCHIAT DANUB
JI Psychiatr. Danub.
PD MAR
PY 2011
VL 23
IS 1
BP 34
EP 44
PG 11
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 752OT
UT WOS:000289702700005
PM 21448095
DA 2025-06-11
ER

PT J
AU Speer, KE
   Naumovski, N
   McKune, A
AF Speer, Kathryn E.
   Naumovski, Nenad
   McKune, Andrew
TI Heart rate variability to track autonomic nervous system health in young
   children: Effects of physical activity and cardiometabolic risk factors
SO PHYSIOLOGY & BEHAVIOR
LA English
DT Article
DE Autonomic nervous system or ANS; Heart rate variability or HRV; Physical
   activity; Children; Cardiometabolic disease
ID CARDIORESPIRATORY FITNESS; VAGAL REGULATION; INFANT DIET; EXERCISE;
   STRESS; INTERVENTION; BIOFEEDBACK; OVERWEIGHT; ADOLESCENT; ADIPOSITY
AB Evidence for a key role of dysregulated autonomic nervous system (ANS) activity in maladaptive stress response/recovery and non-communicable disease development is extensive. Monitoring ANS activity via regular heart rate variability (HRV) measurement is growing in popularity in adult populations given that low HRV has been associated with ANS dysregulation, poor stress response/reactivity, increased cardiometabolic disease risk and early mortality. Although cardiometabolic disease may originate in early life, regular HRV measurement for assessing ANS activity in childhood populations, especially those consisting of children < 6 years of age, remains largely unpractised. A greater understanding of ANS activity modifiers in early life may improve analysis and interpretation of HRV measurements, thereby optimising its usefulness. Taking into consideration that HRV and ANS activity can be improved via daily engagement in physical activity (PA), this review will discuss the ANS and HRV, ANS activity modifiers, cardiometabolic disease risk factors and PA as they relate to childhood/adolescent populations (<= 18 years old).
C1 [Speer, Kathryn E.; Naumovski, Nenad; McKune, Andrew] Univ Canberra, Fac Hlth, 11 Kirinari St, Bruce, ACT 2617, Australia.
   [Speer, Kathryn E.; Naumovski, Nenad; McKune, Andrew] Univ Canberra, Funct Foods & Nutr Res FFNR Lab, 11 Kirinari St, Bruce, ACT 2617, Australia.
   [Speer, Kathryn E.; Naumovski, Nenad; McKune, Andrew] Univ Canberra, Res Inst Sport & Exercise, 11 Kirinari St, Bruce 2617, Australia.
   [McKune, Andrew] Univ KwaZulu Natal, Sch Hlth Sci, Discipline Biokinet Exercise & Leisure Sci, ZA-4000 Durban, Kwazulu Natal, South Africa.
   [Naumovski, Nenad] Harokopio Univ, Sch Hlth Sci & Educ, Dept Nutr & Dietet, Athens 17671, Greece.
   [Speer, Kathryn E.] 11 Kirinari St, Bruce 2617, Australia.
C3 University of Canberra; University of Canberra; University of Canberra;
   University of Kwazulu Natal; Harokopio University Athens
RP Speer, KE (corresponding author), 11 Kirinari St, Bruce 2617, Australia.
EM katie.speer@canberra.edu.au
RI McKune, Andrew/AAM-3086-2020; Naumovski, Nenad/O-5617-2015
FU Hospital Research Foundation [2019/054-83100]
FX This article did not receive any specific grant from funding agencies in
   the public, commercial, or not -for-profit sectors. AJM's and NN's
   research on children and the autonomic nervous system is funded by The
   Hospital Research Foundation, Grant ID: 2019/054-83100.
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NR 86
TC 3
Z9 3
U1 2
U2 9
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0031-9384
EI 1873-507X
J9 PHYSIOL BEHAV
JI Physiol. Behav.
PD JUL 1
PY 2024
VL 281
AR 114576
DI 10.1016/j.physbeh.2024.114576
EA MAY 2024
PG 6
WC Psychology, Biological; Behavioral Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Behavioral Sciences
GA TB1E1
UT WOS:001238697500001
PM 38692385
DA 2025-06-11
ER

PT J
AU Capellini, VK
   Celotto, AC
   Baldo, CF
   Olivon, VC
   Viaro, F
   Rodrigues, AJ
   Evora, PRB
AF Capellini, Verena K.
   Celotto, Andrea C.
   Baldo, Caroline F.
   Olivon, Vania C.
   Viaro, Fernanda
   Rodrigues, Alfredo J.
   Evora, Paulo R. B.
TI Diabetes and Vascular Disease: Basic Concepts of Nitric Oxide
   Physiology, Endothelial Dysfunction, Oxidative Stress and Therapeutic
   Possibilities
SO CURRENT VASCULAR PHARMACOLOGY
LA English
DT Article
DE Endothelium; nitric oxide; diabetes; vascular dysfunction; oxidative
   stress; antioxidants; advanced glycation end-products
ID GLYCATION END-PRODUCTS; ALPHA-LIPOIC ACID; PROTEIN-KINASE-C;
   LOW-DENSITY-LIPOPROTEIN; INTIMA-MEDIA THICKNESS; VITAMIN-E
   SUPPLEMENTATION; SMOOTH-MUSCLE RELAXATION; 3RD NATIONAL-HEALTH; ERECTILE
   DYSFUNCTION; METABOLIC SYNDROME
AB The vascular manifestations associated with diabetes mellitus (DM) result from the dysfunction of several vascular physiology components mainly involving the endothelium, vascular smooth muscle and platelets. It is also known that hyperglycemia-induced oxidative stress plays a role in the development of this dysfunction. This review considers the basic physiology of the endothelium, especially related to the synthesis and function of nitric oxide. We also discuss the pathophysiology of vascular disease associated with DM. This includes the role of hyperglycemia in the induction of oxidative stress and the role of advanced glycation end-products. We also consider therapeutic strategies.
C1 [Capellini, Verena K.; Celotto, Andrea C.; Baldo, Caroline F.; Olivon, Vania C.; Viaro, Fernanda; Rodrigues, Alfredo J.; Evora, Paulo R. B.] Univ Sao Paulo, Dept Cirurgia & Anat, Fac Med Ribeirao Preto, BR-14048900 Ribeirao Preto, SP, Brazil.
C3 Universidade de Sao Paulo
RP Capellini, VK (corresponding author), Univ Sao Paulo, Dept Cirurgia & Anat, Fac Med Ribeirao Preto, 9 Andar HC,Av Bandeirantes 3900, BR-14048900 Ribeirao Preto, SP, Brazil.
EM verenacapellini@yahoo.com.br
RI Olivon, Vania Claudia/GNH-1889-2022; Rodrigues, Alfredo/C-3426-2013;
   Evora, Paulo/C-3351-2013; Celotto, Andrea/G-2370-2012
OI Celotto, Andrea/0000-0003-0037-7468; Olivon, Vania/0000-0001-6689-0972;
   Rodrigues, Alfredo J/0000-0002-0654-2893
FU CAPES (Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior);
   FAPESP (Fundacao de Amparo a Pesquisa do Estado de Sao Paulo); FAEPA
   (Fundacao de Apoio ao Ensino, Pesquisa e Assistencia do Hospital das
   Clinicas da Faculdade de Medicina de Ribeirao Preto da Universidade de
   Sao Paulo), Brazil
FX The work in the authors' laboratory is supported by CAPES (Coordenacao
   de Aperfeicoamento de Pessoal de Nivel Superior), FAPESP (Fundacao de
   Amparo a Pesquisa do Estado de Sao Paulo) and FAEPA (Fundacao de Apoio
   ao Ensino, Pesquisa e Assistencia do Hospital das Clinicas da Faculdade
   de Medicina de Ribeirao Preto da Universidade de Sao Paulo), Brazil.
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NR 242
TC 46
Z9 49
U1 1
U2 9
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1570-1611
EI 1875-6212
J9 CURR VASC PHARMACOL
JI Current Vascular Pharmacology
PD JUL
PY 2010
VL 8
IS 4
BP 526
EP 544
PG 19
WC Pharmacology & Pharmacy; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Cardiovascular System & Cardiology
GA 628LZ
UT WOS:000280122900009
PM 19485895
DA 2025-06-11
ER

PT J
AU Karaca, M
   Coban, E
   Felek, R
   Unal, M
AF Karaca, Mustafa
   Coban, Erkan
   Felek, Rasih
   Unal, Mustafa
TI The Association of Oxidative Stress with Hypertensive Retinopathy
SO CLINICAL AND EXPERIMENTAL HYPERTENSION
LA English
DT Article
DE gamma-glutamyl transferase; oxidative stress; hypertension; hypertensive
   retinopathy
ID GAMMA-GLUTAMYL-TRANSFERASE; METABOLIC SYNDROME; CARDIOVASCULAR-DISEASE;
   RISK; DETERMINANTS; PLASMA; LEVEL
AB This study was designed to answer the following questions: (i) Do levels of serum gamma-glutamyl transferase (GGT), a marker of oxidative stress, change in hypertensive retinopathy (HR)? (ii) Is there any relation between degree of HR and GGT levels? This study included 80 hypertensive patients with HR. Group 1 comprised 40 patients with grade I HR, and group 2 comprised 40 patients with grade II HR. We selected 40 healthy subjects for the control group. Level of GGT in group 2 was significantly higher than in group 1 (P = 0.005) and control group (P = 0.001); it was also higher in group 1 than in control group (P = 0.025). Our study suggests that oxidative stress, mechanisms known to be involved in vascular lesions, may promote the development of HR.
C1 [Karaca, Mustafa; Coban, Erkan] Akdeniz Univ, Dept Internal Med, Fac Med, TR-07070 Antalya, Turkey.
   [Felek, Rasih] Akdeniz Univ, Cent Lab, Fac Med, TR-07070 Antalya, Turkey.
   [Unal, Mustafa] Akdeniz Univ, Dept Ophthalmol, Fac Med, TR-07070 Antalya, Turkey.
C3 Akdeniz University; Akdeniz University; Akdeniz University
RP Coban, E (corresponding author), Akdeniz Univ, Dept Internal Med, Fac Med, TR-07070 Antalya, Turkey.
EM ecoban@akdeniz.edu.tr
RI Coban, Erkan/AAA-7821-2021; Felek, Rasih/I-8896-2017; ÜNAL,
   MUSTAFA/C-7426-2016
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NR 29
TC 9
Z9 10
U1 0
U2 7
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1064-1963
EI 1525-6006
J9 CLIN EXP HYPERTENS
JI Clin. Exp. Hypertens.
PY 2013
VL 35
IS 1
BP 16
EP 19
DI 10.3109/10641963.2012.685535
PG 4
WC Pharmacology & Pharmacy; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Cardiovascular System & Cardiology
GA 061SY
UT WOS:000312869700004
PM 22571627
DA 2025-06-11
ER

PT J
AU Palomer, X
   Pizarro-Delgado, J
   Vázquez-Carrera, M
AF Palomer, Xavier
   Pizarro-Delgado, Javier
   Vazquez-Carrera, Manuel
TI Emerging Actors in Diabetic Cardiomyopathy: Heartbreaker Biomarkers or
   Therapeutic Targets?
SO TRENDS IN PHARMACOLOGICAL SCIENCES
LA English
DT Review
ID ENDOPLASMIC-RETICULUM STRESS; HEART-FAILURE; INSULIN-RESISTANCE;
   DIASTOLIC DYSFUNCTION; PHARMACOLOGICAL INHIBITION; TRANSCRIPTIONAL
   REGULATION; METABOLIC SYNDROME; OXIDATIVE STRESS; PPAR-BETA/DELTA;
   DOWN-REGULATION
AB The diabetic heart is characterized by metabolic disturbances that are often accompanied by local inflammation, oxidative stress, myocardial fibrosis, and cardiomyocyte apoptosis. Overall changes result in contractile dysfunction, concentric left ventricular (LV) hypertrophy, and dilated cardiomyopathy, that together affect cardiac output and eventually lead to heart failure, the foremost cause of death in diabetic patients. There are currently several validated biomarkers for the diagnosis and risk assessment of cardiac diseases, but none is capable of discriminating patients with diabetic cardiomyopathy (DCM). In this review we point to several novel candidate biomarkers from new activated molecular pathways (including microRNAs) with the potential to detect or prevent DCM in its early stages, or even to treat it once established. The prospective use of selected biomarkers that integrate inflammation, oxidative stress, fibrosis, and metabolic dysregulation is widely discussed.
C1 [Palomer, Xavier; Pizarro-Delgado, Javier; Vazquez-Carrera, Manuel] IBUB, Dept Pharmacol Toxicol & Therapeut Chem, Barcelona, Spain.
   [Palomer, Xavier; Pizarro-Delgado, Javier; Vazquez-Carrera, Manuel] Hosp St Joan de Deu, Res Inst, Barcelona, Spain.
   [Palomer, Xavier; Pizarro-Delgado, Javier; Vazquez-Carrera, Manuel] Univ Barcelona, Fac Pharm & Food Sci, Ctr Invest Biomed Red CIBER Diabet & Enfermedades, Barcelona, Spain.
C3 University of Barcelona; University of Barcelona; CIBER - Centro de
   Investigacion Biomedica en Red; CIBEREHD; University of Barcelona
RP Vázquez-Carrera, M (corresponding author), IBUB, Dept Pharmacol Toxicol & Therapeut Chem, Barcelona, Spain.; Vázquez-Carrera, M (corresponding author), Hosp St Joan de Deu, Res Inst, Barcelona, Spain.; Vázquez-Carrera, M (corresponding author), Univ Barcelona, Fac Pharm & Food Sci, Ctr Invest Biomed Red CIBER Diabet & Enfermedades, Barcelona, Spain.
EM mvazquezcarrera@ub.edu
RI PIZARRO-DELGADO, JAVIER/E-7268-2012; Vazquez-Carrera, Manuel/H-2612-2015
OI PIZARRO-DELGADO, JAVIER/0000-0002-3735-844X; Vazquez-Carrera,
   Manuel/0000-0001-7138-8207; Palomer, Xavier/0000-0001-7647-9984
FU Spanish Ministry of Economy and Competitiveness [SAF2015-64146-R];
   Fundacio La Marato de TV3; CIBER de Diabetes y Enfermedades Metabolicas
   Asociadas (CIBERDEM)
FX We apologize to contributors to the field whose work could not be cited
   here owing to space restrictions. We thank the University of Barcelona
   Language Advisory Service for their assistance. Funding for the authors
   is from the Spanish Ministry of Economy and Competitiveness
   (SAF2015-64146-R), the Fundacio La Marato de TV3, and CIBER de Diabetes
   y Enfermedades Metabolicas Asociadas (CIBERDEM). CIBERDEM is an
   initiative of the Instituto de Salud Carlos III (ISCIII), Spanish
   Ministry of Economy and Competitiveness.
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NR 109
TC 76
Z9 79
U1 0
U2 22
PU ELSEVIER SCIENCE LONDON
PI LONDON
PA 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND
SN 0165-6147
EI 1873-3735
J9 TRENDS PHARMACOL SCI
JI Trends Pharmacol. Sci.
PD MAY
PY 2018
VL 39
IS 5
BP 452
EP 467
DI 10.1016/j.tips.2018.02.010
PG 16
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA GD5QY
UT WOS:000430562900003
PM 29605388
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Morgan, VA
   Waterreus, A
   Carr, V
   Castle, D
   Cohen, M
   Harvey, C
   Galletly, C
   Mackinnon, A
   McGorry, P
   McGrath, JJ
   Neil, AL
   Saw, S
   Badcock, JC
   Foley, DL
   Waghorn, G
   Coker, S
   Jablensky, A
AF Morgan, Vera A.
   Waterreus, Anna
   Carr, Vaughan
   Castle, David
   Cohen, Martin
   Harvey, Carol
   Galletly, Cherrie
   Mackinnon, Andrew
   McGorry, Patrick
   McGrath, John J.
   Neil, Amanda L.
   Saw, Suzy
   Badcock, Johanna C.
   Foley, Debra L.
   Waghorn, Geoff
   Coker, Sarah
   Jablensky, Assen
TI Responding to challenges for people with psychotic illness: Updated
   evidence from the Survey of High Impact Psychosis
SO AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
LA English
DT Review
DE Employment; social isolation; physical health; victimisation;
   schizophrenia
ID AUSTRALIAN NATIONAL-SURVEY; CARDIOMETABOLIC RISK-FACTORS; SERIOUS
   MENTAL-ILLNESS; VIOLENT VICTIMIZATION; DISORDERS DATA; SCHIZOPHRENIA;
   EMPLOYMENT; ADULTS; PREVALENCE; HEALTH
AB Objective: The objective is to summarise recent findings from the 2010 Australian Survey of High Impact Psychosis (SHIP) and examine their implications for future policy and planning to improve mental health, physical health and other circumstances of people with a psychotic disorder.
   Methods: Survey of High Impact Psychosis collected nationally representative data on 1825 people with psychotic illness. Over 60 papers have been published covering key challenges reported by participants: financial problems, loneliness and social isolation, unemployment, poor physical health, uncontrolled symptoms of mental illness, and lack of stable, suitable housing. Findings are summarised under the rubric of participant-ranked top challenges.
   Results: The main income source for the majority (85%) of participants was a government benefit. Only one-third was employed, and the most appropriate employment services for this group were under-utilised. High rates of loneliness and social isolation impacted mental and physical health. The rate of cardiometabolic disease was well above the general population rate, and associated risk factors were present from a very young age. Childhood abuse (30.6%), adult violent victimisation (16.4%) and alcohol and substance abuse/dependence (lifetime rates of 50.5% and 54.5%, respectively) complicated the clinical profile. Treatment with medication was suboptimal, with physical health conditions undertreated, a high rate of psychotropic polypharmacy and underutilisation of clozapine in chronic persistent psychotic illness. Only 38.6% received evidence-based psychosocial therapies. In the previous year, 27.4% had changed housing and 12.8% had been homeless, on average for 155days.
   Conclusion: Money, social engagement and employment are the most important challenges for people with psychotic illness, as well as good physical and mental health. An integrated approach to recovery is needed to optimise service delivery and augment evidence-based clinical practice with measures to improve physical health and social circumstances. Meeting these challenges has the potential to reduce costs to government and society, as well as promote recovery.
C1 [Morgan, Vera A.; Waterreus, Anna] Univ Western Australia, Sch Psychiat & Clin Neurosci, Neuropsychiat Epidemiol Res Unit, Crawley, WA, Australia.
   [Morgan, Vera A.; Badcock, Johanna C.; Jablensky, Assen] Univ Western Australia, Sch Psychiat & Clin Neurosci, Ctr Clin Res Neuropsychiat, Crawley, WA, Australia.
   [Carr, Vaughan] Univ New South Wales, Sch Psychiat, Res Unit Schizophrenia Epidemiol, Sydney, NSW, Australia.
   [Carr, Vaughan] Schizophrenia Res Inst, Sydney, NSW, Australia.
   [Carr, Vaughan] Neurosci Res Australia, Sydney, NSW, Australia.
   [Carr, Vaughan] Monash Univ, Sch Clin Sci, Dept Psychiat, Melbourne, Vic, Australia.
   [Castle, David] St Vincents Hosp, Melbourne, Vic, Australia.
   [Castle, David; Harvey, Carol] Univ Melbourne, Dept Psychiat, Melbourne, Vic, Australia.
   [Cohen, Martin] Hunter New England Mental Hlth, Newcastle, NSW, Australia.
   [Cohen, Martin] Univ Newcastle, Newcastle, NSW, Australia.
   [Galletly, Cherrie] Univ Adelaide, Sch Med, Discipline Psychiat, Adelaide, SA, Australia.
   [Galletly, Cherrie] Ramsay Hlth Care, Mental Hlth Serv, Adelaide, SA, Australia.
   [Galletly, Cherrie] Northern Adelaide Local Hlth Network, Adelaide, SA, Australia.
   [Mackinnon, Andrew] Black Dog Inst, Sydney, NSW, Australia.
   [Mackinnon, Andrew] Univ New South Wales, Sydney, NSW, Australia.
   [Mackinnon, Andrew] Univ Melbourne, Melbourne Sch Populat & Global Hlth, Ctr Mental Hlth, Melbourne, Vic, Australia.
   [McGorry, Patrick] Orygen Youth Hlth Res Ctr, Melbourne, Vic, Australia.
   [McGrath, John J.] Univ Queensland, Queensland Brain Inst, Brisbane, Qld, Australia.
   [McGrath, John J.; Waghorn, Geoff] Queensland Ctr Mental Hlth Res, Brisbane, Qld, Australia.
   [Neil, Amanda L.] Univ Tasmania, Inst Med Res, Hobart, Tas, Australia.
   [Saw, Suzy] Hlth Data Anal Pty Ltd, Canberra, ACT, Australia.
   [Badcock, Johanna C.; Jablensky, Assen] Cooperat Res Ctr Mental Hlth, Carlton, Vic, Australia.
   [Foley, Debra L.] Univ Melbourne, Melbourne Sch Populat & Global Hlth, Ctr Epidemiol & Biostat, Fac Med Dent & Hlth Sci, Melbourne, Vic, Australia.
   [Coker, Sarah] SANE Australia, Melbourne, Vic, Australia.
C3 University of Western Australia; University of Western Australia;
   University of New South Wales Sydney; Schizophrenia Research Institute;
   Neuroscience Research Australia; Monash University; St Vincent's Health;
   St Vincent's Hospital Melbourne; NSW Health; St Vincents Hospital
   Sydney; University of Melbourne; University of Newcastle; University of
   Adelaide; Ramsay Health Care Limited; Black Dog Institute; University of
   New South Wales Sydney; University of Melbourne; Orygen, The National
   Centre of Excellence in Youth Mental Health; University of Queensland;
   Queensland Centre for Mental Health Research; University of Sydney;
   Westmead Institute for Medical Research; University of Tasmania;
   Cooperative Research Centre for Mental Health; University of Melbourne
RP Morgan, VA (corresponding author), Univ Western Australia, Sch Psychiat & Clin Neurosci, Neuropsychiat Epidemiol Res Unit, M571,35 Stirling Highway, Crawley, WA 6009, Australia.
EM vera.morgan@uwa.edu.au
RI McGorry, Patrick/O-4115-2019; Sponheim, Scott/J-3857-2017; Badcock,
   Johanna/C-3682-2013; Morgan, Vera/U-4851-2019; Mackinnon,
   Andrew/A-4901-2008; Harvey, Carol/KHB-1944-2024; Neil,
   Amanda/L-9052-2013; McGrath, John/G-5493-2010
OI Castle, David/0000-0002-3075-1580; McGorry, Patrick/0000-0002-3789-6168;
   Neil, Amanda/0000-0002-1344-6672; McGrath, John/0000-0002-4792-6068;
   Waterreus, Anna/0000-0002-1648-7701
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NR 95
TC 86
Z9 92
U1 0
U2 21
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0004-8674
EI 1440-1614
J9 AUST NZ J PSYCHIAT
JI Aust. N. Z. J. Psych.
PD FEB
PY 2017
VL 51
IS 2
BP 124
EP 140
DI 10.1177/0004867416679738
PG 17
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA EL5PB
UT WOS:000394672000005
PM 27913580
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Aliyazicioglu, R
   Deger, O
   Kural, BV
   Hocaoglu, Ç
   Çolak, M
   Yücesan, FB
AF Aliyazicioglu, Rezzan
   Deger, Orhan
   Kural, Birgul Vanizor
   Hocaoglu, Cicek
   Colak, Meltem
   Yucesan, Fulya Balaban
TI The Relationship Between the Peroxisome Proliferator-Activated Receptor
   Gamma 2 Gene Polymorphism, Lipids and Adipokines in Patients with Major
   Depression
SO TURKIYE KLINIKLERI TIP BILIMLERI DERGISI
LA English
DT Article
DE Adipokines; lipids; major depressive disorder; single nucleotide
   polymorphisms; PPAR gamma
ID INSULIN-RESISTANCE; PRO12ALA POLYMORPHISM; METABOLIC SYNDROME;
   DIABETES-MELLITUS; BODY-MASS; EXPRESSION; OBESITY; ADIPONECTIN;
   PPAR-GAMMA-2; LEPTIN
AB Objective: Peroxisome proliferator-activated receptor gamma (PPAR gamma), lipids, lipoproteins, and adipokines have recently been shown to be associated with psychiatric diseases. Our major aim is to investigate the contribution of the PPAR gamma gene polymorphism, adipokines, lipids, and lipoproteins to the development of major depression. Material and Methods: The frequency of Pro12Ala in exon 2 and C478T in exon 6 of the PPAR gamma gene, lipids and adipokines in major depression (n = 78) and control subjects (n = 64) were analyzed. Genotypes of PPAR gamma gene polymorphisms were examined. Serum leptin, adiponectin, and resistin were studied by enzyme-linked immunosorbent assay (ELISA). Serum apo A1, apo B, and Lp(a) levels were determined by immunonephelometry. Serum total cholesterol, triglyceride, HDL-cholesterol and LDL-cholesterol levels were analyzed by enzymatic methods. Results: The genotypes of exon 2 and exon 6 distribution did not differ between the control subjects and patients with major depression. Frequencies of genotypes of Pro12Ala, and Ala12Ala in exon 2 in overweight and obese patients with major depression were higher than those of overweight and obese controls. C478T polymorphism was highest in overweight and obese patients with major depression. Pro12Ala and Ala12Ala genotypes in exon 2 of PPAR gamma gene in patients were found to be associated with triglyceride and HDL-cholesterol. There were significant differences regarding glucose, total cholesterol, LDL-cholesterol, apo B, Lp(a), adiponectin and resistin levels between patient and control subjects. Conclusion: PPAR gamma exon gene polymorphisms, alterations in lipid profile and adipokines may be associated with the development of major depression.
C1 [Deger, Orhan; Kural, Birgul Vanizor; Yucesan, Fulya Balaban] Karadeniz Tech Univ, Fac Med, Dept Biochem, Trabzon, Turkey.
   [Aliyazicioglu, Rezzan] Karadeniz Tech Univ, Fac Pharm, Dept Biochem, Trabzon, Turkey.
   [Hocaoglu, Cicek] Rize Univ, Fac Med, Dept Psychiat, Rize, Turkey.
   [Colak, Meltem] Gumushane Univ, High Sch Hlth, Dept Nursing, Gumushane, Turkey.
C3 Karadeniz Technical University; Karadeniz Technical University; Recep
   Tayyip Erdogan University; Ministry of National Education - Turkey;
   Gumushane University
RP Deger, O (corresponding author), Karadeniz Tech Univ, Fac Med, Dept Biochem, Trabzon, Turkey.
EM orhandeger@hotmail.com
RI Hocaoglu, Cicek/B-2543-2014; YÜCESAN, Fulya/AAR-5398-2020; Deger,
   Orhan/ABF-9220-2020; ALİYAZICIOĞLU, REZZAN/AAK-2965-2021
OI VANIZOR KURAL, Birgul/0000-0003-0730-9660
FU Karadeniz Technical University [2006. 101. 0014. 1]
FX The authors thank Karadeniz Technical University Resarch Fund (Project
   no: 2006. 101. 0014. 1) for supplying financial support.
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NR 33
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Z9 9
U1 0
U2 9
PU ORTADOGU AD PRES & PUBL CO
PI ANKARA
PA TURKOCAGI CAD NO 30, BALGAT, ANKARA, 06520, TURKEY
SN 1300-0292
J9 TURK KLIN TIP BILIM
JI Turk. Klin. Tip Bilim. Derg.
PD OCT
PY 2011
VL 31
IS 5
BP 1065
EP 1072
DI 10.5336/medsci.2010-20010
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 853OD
UT WOS:000297434700003
OA hybrid
DA 2025-06-11
ER

PT J
AU Wang, YL
   Zhou, X
   Li, DL
   Ye, JM
AF Wang, Ya-lin
   Zhou, Xiu
   Li, Dong-li
   Ye, Ji-ming
TI Role of the mTOR-autophagy-ER stress pathway in high fructose-induced
   metabolic-associated fatty liver disease
SO ACTA PHARMACOLOGICA SINICA
LA English
DT Review
DE mTOR; autophagy; ER stress; MAFLD; metabolic syndrome; high-fructose
   diet
ID ENDOPLASMIC-RETICULUM STRESS; INSULIN SIGNALING TRANSDUCTION; HEPATIC
   STEATOSIS; RAT-LIVER; ZEBRAFISH; COMPLEX; TARGET; DIET; INFLAMMATION;
   DIAGNOSIS
AB Metabolic-associated fatty liver disease (MAFLD) is the most common metabolic disease with a global prevalence of 25%. While MAFLD is serious and incurable at the later stage, it can be controlled or reversed at the early stage of hepatosteatosis originating from unhealthy diets. Recent laboratory evidence implicates a critical role of the mammalian target of rapamycin (mTOR)-autophagy signaling pathway in the pathogenesis of MAFLD induced by a high-fructose diet mimicking the overconsumption of sugar in humans. This review discusses the possible molecular mechanisms of mTOR-autophagy-endoplasmic reticulum (ER) stress in MAFLD. Based on careful analysis of recent studies, we suggest possible new therapeutic concepts or targets that can be explored for the discovery of new anti-MAFLD drugs.
C1 [Wang, Ya-lin; Zhou, Xiu; Li, Dong-li; Ye, Ji-ming] Wuyi Univ, Biotechnol & Hlth Sci, Jiangmen 529020, Peoples R China.
   [Zhou, Xiu; Ye, Ji-ming] RMIT Univ, Sch Hlth & Biomed Sci, Melbourne, Vic, Australia.
C3 Wuyi University; Royal Melbourne Institute of Technology (RMIT)
RP Ye, JM (corresponding author), Wuyi Univ, Biotechnol & Hlth Sci, Jiangmen 529020, Peoples R China.
EM jiming.ye@rmit.edu.au
FU National Natural Science Foundation of China [81870608]; Jiangmen
   Innovation Research Team Project Fund [2018630100180019806]
FX The authors would like to acknowledge Prof Li-hong Hu and Prof Hua-liang
   Jiang (Shanghai Institute of Materia Medica, China) for collaborative
   research on matrine. We would also like to thank Dr. Hao Wang (RMIT
   University, Australia), who significantly contributed to our initial
   study on the relationship among mTOR, autophagy and ER stress in high
   fructose-induced hepatosteatosis. This review was supported in part by
   the National Natural Science Foundation of China (81870608) and Jiangmen
   Innovation Research Team Project Fund (2018630100180019806).
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NR 60
TC 26
Z9 28
U1 3
U2 32
PU NATURE PUBL GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1671-4083
EI 1745-7254
J9 ACTA PHARMACOL SIN
JI Acta Pharmacol. Sin.
PD JAN
PY 2022
VL 43
IS 1
BP 10
EP 14
DI 10.1038/s41401-021-00629-0
EA MAR 2021
PG 5
WC Chemistry, Multidisciplinary; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Pharmacology & Pharmacy
GA YA0WH
UT WOS:000629887300001
PM 33731774
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Pompili, M
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   Seretti, Maria E.
   Montebovi, Franco
   Lamis, Dorian A.
   Serafini, Gianluca
   Amore, Mario
   Girardi, Paolo
TI Do Stroke Patients have an Increased Risk of Developing Suicidal
   Ideation or Dying by Suicide? An Overview of the Current Literature
SO CNS NEUROSCIENCE & THERAPEUTICS
LA English
DT Review
DE Intervention; Poststroke depression; Prevention; Stroke; Suicide
ID BIPOLAR-DISORDER; METABOLIC SYNDROME; MAJOR DEPRESSION; MEDICAL ILLNESS;
   POPULATION; ASSOCIATION; DISEASE; SCHIZOPHRENIA; HYPERTENSION;
   PREVALENCE
AB Stroke is a leading cause of death that affects 15 million people worldwide each year. Increasing evidence suggests that stroke confers substantial risk for suicide and following a stroke, patients frequently develop poststroke depression, which is a well-established risk factor for suicide. In this overview of the current literature, we examined the association between suffering a stroke and subsequent risk for suicide and suicidal ideation. We performed a careful MedLine, Excerpta Medica, PsycLit, PsycInfo, and Index Medicus search to identify all articles and book chapters in English. We initially selected 31 articles published between 1990 and 2011; however, only 16 studies were included in this review. All articles identified stroke as a significant risk factor for suicide, especially among depressed patients, providing further support for poststroke depression and suicidality. The results also indicated that there were differences between patients who developed acute-onset suicidal plans and those who reported delayed-onset plans, which occurred more frequently. Many of the stroke patients who died by suicide suffered from depression prior to their death, suggesting that being diagnosed with a mood disorder contributes to an increased risk of suicide in this population. Suffering from a stroke increases the risk of dying by suicide and developing suicidal ideation, particularly in young adults and women. The factors found to confer the most risk for suicidality were depression, previous mood disorder, prior history of stroke, and cognitive impairment.
C1 [Pompili, Maurizio; Seretti, Maria E.; Serafini, Gianluca; Girardi, Paolo] Univ Roma La Sapienza, St Andrea Hosp, Suicide Prevent Ctr, Dept Neurosci Mental Hlth & Sensory Organs, I-00189 Rome, Italy.
   [Pompili, Maurizio] Harvard Univ, McLean Hosp, Sch Med, Belmont, MA USA.
   [Venturini, Paola; Campi, Sandra; Montebovi, Franco] Univ Roma La Sapienza, Fac Med & Psychol, Psychiat Residency Program, I-00189 Rome, Italy.
   [Lamis, Dorian A.] Emory Univ, Sch Med, Dept Psychiat & Behav Sci, Atlanta, GA USA.
   [Amore, Mario] Univ Parma, Sect Psychiat, Dept Neurosci, I-43100 Parma, Italy.
C3 Sapienza University Rome; Azienda Ospedaliera Sant'Andrea; Harvard
   University; Harvard University Medical Affiliates; McLean Hospital;
   Sapienza University Rome; Emory University; University of Parma
RP Pompili, M (corresponding author), Univ Roma La Sapienza, St Andrea Hosp, Suicide Prevent Ctr, Dept Neurosci Mental Hlth & Sensory Organs, 1035-1039 Via Grottarossa, I-00189 Rome, Italy.
EM maurizio.pompili@uniroma1.it
RI Altamura, Mario/IQS-2773-2023; Lamis, Dorian/AAM-3651-2020; Pompili,
   Maurizio/AAC-1011-2019; Serafini, Gianluca/K-6603-2016
OI Lamis, Dorian/0000-0001-5405-0239; Pompili,
   Maurizio/0000-0003-1886-4977; Serafini, Gianluca/0000-0002-6631-856X
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NR 55
TC 84
Z9 89
U1 1
U2 16
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1755-5930
J9 CNS NEUROSCI THER
JI CNS Neurosci. Ther.
PY 2012
VL 18
IS 9
BP 711
EP 721
DI 10.1111/j.1755-5949.2012.00364.x
PG 11
WC Neurosciences; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Pharmacology & Pharmacy
GA 999CU
UT WOS:000308287500001
PM 22943140
OA Green Published
DA 2025-06-11
ER

PT J
AU Boyle, SH
   Jackson, WG
   Suarez, EC
AF Boyle, Stephen H.
   Jackson, William G.
   Suarez, Edward C.
TI Hostility, anger, and depression predict increases in C3 over a 10-year
   period
SO BRAIN BEHAVIOR AND IMMUNITY
LA English
DT Article
DE complement; hostility; anger; depression; men
ID ADRENERGIC-RECEPTOR RESPONSIVENESS; ACUTE MYOCARDIAL-INFARCTION;
   CORONARY-HEART-DISEASE; COMPLEMENT C3; REACTIVE PROTEIN; PLASMA
   INTERLEUKIN-6; INSULIN-RESISTANCE; METABOLIC SYNDROME; BLOOD MONOCYTES;
   RISK-FACTORS
AB We examined the relation of hostility, anger, and depression to 10-year changes in the third (C3), and fourth (C4) complement in 313, apparently healthy male participants enrolled in the Air Force Health Study (AFHS), a 20-year study designed to evaluate the health co sequences of dioxin exposure. Hostility, depression, and anger were assessed using subscales from the Minnesota Multiphasic Personality Inventory (MMPI), which was administered in 1985. Given the high intercorrelations among these psychological scales, we used a principal component analysis to generate a composite score representing the linear combination of the hostility, anger, and depression scales. The dependent variables, C3 and C4 levels, were determined from samples collected in 1992, 1997, and 2002. Regression analyses controlling for age, race, alcohol use, body mass index, and cigarette use as well as onset of disease, and use of lipid lowering and blood pressure medications during follow-up revealed a significant time x composite score interaction for C3 complement (p <.0003), but not C4. Post-hoc analyses revealed that high composite scores were associated with larger 10-year increases in C3. These observations suggest that men who are hostile and are prone to experience frequent and intense feelings of anger, and depression show activation of the complement system, and specifically increases in C3, that may contribute to the development of coronary heart disease. (C) 2007 Elsevier Inc. All rights reserved.
C1 Duke Univ, Med Ctr, Dept Psychiat & Behav Sci, Durham, NC 27710 USA.
   USAF, Res Lab, Brooks City Base, TX USA.
C3 Duke University; United States Department of Defense; United States Air
   Force
RP Boyle, SH (corresponding author), Duke Univ, Med Ctr, Dept Psychiat & Behav Sci, POB 3328, Durham, NC 27710 USA.
EM boyle020@mc.duke.edu; suare001@mc.duke.edu
RI Suarez, Edward/HPE-3092-2023
OI Suarez, Edward/0000-0003-3069-5846
FU NHLBI NIH HHS [HL67459, R01 HL067459] Funding Source: Medline
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NR 61
TC 37
Z9 48
U1 0
U2 7
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0889-1591
EI 1090-2139
J9 BRAIN BEHAV IMMUN
JI Brain Behav. Immun.
PD AUG
PY 2007
VL 21
IS 6
BP 816
EP 823
DI 10.1016/j.bbi.2007.01.008
PG 8
WC Immunology; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Neurosciences & Neurology; Psychiatry
GA 196SG
UT WOS:000248501700012
PM 17321106
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Locke, B
   Lu, R
AF Locke, Briana
   Lu, Ray
TI Establishment of immortalized porcine intramuscular preadipocytes for
   the study of lipid metabolism
SO BIOCHEMISTRY AND CELL BIOLOGY
LA English
DT Article
DE intramuscular preadipocytes; adipogenesis; lipid metabolism; endoplasmic
   reticulum stress; CREB3
ID UNFOLDED PROTEIN RESPONSE; STRESS-RESPONSE; ADIPOSE-TISSUE; GOLGI
   STRESS; FAT; DIFFERENTIATION; TRANSCRIPTION; ADIPOGENESIS; STEATOSIS;
   PATHWAY
AB Intramuscular adipose tissue is associated with an increased risk for the development of metabolic syndrome. A cellular model of adipogenesis in muscular tissues would be an invaluable tool for studying regulatory factors in this important process. Cellular stress can impact the homeostasis of various metabolic pathways, including lipid metabolism. In this study, a porcine intramuscular preadipocyte cell line was established, which displayed mature adipocyte attributes such as lipid accumulation and increased expression of adipogenic gene markers. Since it is well established that endoplasmic reticulum (ER) and Golgi stress impact adipogenesis, we sought to investigate the effects of ER/Golgi stress and an associated protein, CREB3, in this cell line model. We found that this novel model maintains robust adipogenic capabilities, and that ER stress can negatively affect adipogenic markers. Overall, these findings demonstrate the strength of the new cell model for studying adipogenesis, and highlight the impact of ER stress on lipid metabolism.
C1 [Locke, Briana; Lu, Ray] Univ Guelph, Dept Mol & Cellular Biol, Guelph, ON, Canada.
C3 University of Guelph
RP Lu, R (corresponding author), Univ Guelph, Dept Mol & Cellular Biol, Guelph, ON, Canada.
EM ray.lu@uoguelph.ca
FU Mitacs Accelerate Program; Ontario Genomics; Agricultural Adaptation
   Council; Genome Canada [ON-RP3]
FX This work was supported by the Mitacs Accelerate Program, and Ontario
   Genomics, the Agricultural Adaptation Council, and Genome Canada under
   the Ontario Regional Priorities Partnership Program (ON-RP3) .
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NR 45
TC 0
Z9 0
U1 0
U2 0
PU CANADIAN SCIENCE PUBLISHING
PI OTTAWA
PA 123 Slater Street, Suite 610, OTTAWA, ON K1P 5H2, CANADA
SN 0829-8211
EI 1208-6002
J9 BIOCHEM CELL BIOL
JI Biochem. Cell Biol.
PY 2025
VL 103
AR 0174
DI 10.1139/bcb-2024-0174
PG 11
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA 1PM2J
UT WOS:001470558500001
PM 40127467
DA 2025-06-11
ER

PT J
AU Lanza, GA
   Filice, M
   De Vita, A
   Villano, A
   Manfredonia, L
   Lamendola, P
   Crea, F
AF Lanza, Gaetano A.
   Filice, Monica
   De Vita, Antonio
   Villano, Angelo
   Manfredonia, Laura
   Lamendola, Priscilla
   Crea, Filippo
TI Microvascular Angina - Long-Term Exercise Stress Test Follow-up
SO CIRCULATION JOURNAL
LA English
DT Article
DE Clinical outcome; Exercise stress test; Follow-up; Microvascular angina
ID CARDIAC SYNDROME-X; CHEST-PAIN; CLINICAL CHARACTERISTICS; SENSITIVITY;
   DYSFUNCTION
AB Background: A sizeable proportion of patients with primary stable microvascular angina (MVA; exercise-induced angina, positive exercise stress test [ EST], normal coronary arteries) have recurrent symptoms during follow-up. There have been no previous studies, however, on the long-term results of EST and their correlation with symptom outcome.
   Methods and Results: Follow-up EST was performed in 71 MVA patients at an average of 16.2 years (range, 5-25 years) from the first EST. Angina status was assessed on weekly frequency of angina episodes and nitroglycerin consumption and by whether symptoms had worsened, improved, or remained unchanged over time. At follow-up EST, 41 patients (group 1) had exercise-induced ischemia, whereas 30 patients (group 2) had negative EST. Compared to group 2, group 1 patients more frequently had exercise-induced dyspnea, and had a greater maximum ST-segment depression and a lower coronary blood flow response to adenosine and cold pressor test, but group 2 patients had a more frequent history of rest angina. No differences between the 2 groups were found at follow-up in angina status or change in symptom status during follow-up.
   Conclusions: Electrocardiogram results improve significantly in a sizeable proportion of patients with MVA. Changes in EST results, however, were not associated with clinical outcome.
C1 [Lanza, Gaetano A.; Filice, Monica; De Vita, Antonio; Villano, Angelo; Manfredonia, Laura; Lamendola, Priscilla; Crea, Filippo] Univ Cattolica Sacro Cuore, Univ Hosp Policlin A Gemelli Fdn, Inst Cardiol, Rome, Italy.
C3 Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli
RP Lanza, GA (corresponding author), Univ Cattolica Sacro Cuore, Ist Cardiol, Largo A Gemelli 8, I-00168 Rome, Italy.
EM gaetanoantonio.lanza@unicatt.it
RI De Vita, Antonio/LRC-4736-2024; Crea, Filippo/AAC-9754-2022; Filice,
   Monica/GZM-7376-2022; Villano, Angelo/AAC-7245-2022; Lanza,
   Gaetano/AAC-2660-2019
OI Villano, Angelo/0000-0003-1651-1369; De Vita,
   Antonio/0000-0001-8725-7447
CR CANNON RO, 1990, J AM COLL CARDIOL, V16, P1359, DOI 10.1016/0735-1097(90)90377-2
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NR 13
TC 3
Z9 3
U1 0
U2 0
PU JAPANESE CIRCULATION SOC
PI TOYKO
PA 18TH FLOOR IMPERIAL HOTEL TOWER, 1-1-1 UCHISAIWAI-CHO CHIYODA-KU, TOYKO,
   100-0011, JAPAN
SN 1346-9843
EI 1347-4820
J9 CIRC J
JI Circ. J.
PD APR
PY 2018
VL 82
IS 4
BP 1070
EP 1075
DI 10.1253/circj.CJ-17-0657
PG 6
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA GA1MB
UT WOS:000428079000020
PM 28890527
OA gold
DA 2025-06-11
ER

PT J
AU Weber-Hamann, B
   Hentschel, F
   Kniest, A
   Deuschle, M
   Colla, M
   Lederbogen, F
   Heuser, I
AF Weber-Hamann, B
   Hentschel, F
   Kniest, A
   Deuschle, M
   Colla, M
   Lederbogen, F
   Heuser, I
TI Hypercortisolemic depression is associated with increased
   intra-abdominal fat
SO PSYCHOSOMATIC MEDICINE
LA English
DT Article
DE major depression; hypercortisolemia; visceral fat; insulin resistance
ID MAJOR DEPRESSION; OBESITY; TESTOSTERONE; CORTISOL; DISEASE
AB Objective: Similar to patients with a metabolic syndrome, patients with major depression are at increased risk of developing cardiovascular disorders. Interestingly, both disorders share a specific endocrine syndrome that promotes the accumulation of visceral fat, which again is considered a marker of increased cardiovascular morbidity and mortality. Methods: Intra-abdominal fat was measured in 22 postmenopausal depressed women and 23 age-matched healthy women by computer tomography at the level of lumbar vertebrae 1 (L1) and 4 (L4). Saliva was taken in patients and control subjects at 08:00 hours over a period of 7 drug-free days for the measurement of free cortisol. In patients only we performed an oral glucose tolerance test. Results: Compared with control subjects, depressed patients with elevated free cortisol concentrations showed similar visceral fat depots at L1 (113.0 +/- 41.6 vs. 94.3 +/- 53.2 cm(2)). Hypercortisolemic depressed patients also showed greater fat depots in this area (74.5 +/- 55.5 cm(2), p =.04) than the normocortisolemic patients. However, a comparison of all patients with control subjects revealed no difference in fat accumulation at either L1 or L4. Finally, glucose concentrations during the glucose tolerance test were higher in hypercortisolemic than in normocortisolemic patients, whereas their insulin levels showed only a tendency toward being increased. Conclusions: Hvpercortisolemic depressed patients suffer from resistance to insulin and increased visceral fat. The fact that hypercortisolemia reverses depression-related fat loss, particularly in the visceral area, might partially explain why major depression can be considered a risk factor for cardiovascular disorders.
C1 Free Univ Berlin, Univ Hosp Benjamin Franklin, Dept Psychiat, D-14050 Berlin, Germany.
   Cent Inst Mental Hlth, D-6800 Mannheim, Germany.
C3 Berlin Institute of Health; Free University of Berlin; Humboldt
   University of Berlin; Charite Universitatsmedizin Berlin; Central
   Institute of Mental Health
RP Heuser, I (corresponding author), Free Univ Berlin, Univ Hosp Benjamin Franklin, Dept Psychiat, Eschenallee 3, D-14050 Berlin, Germany.
RI Deuschle, Michael/E-4638-2012; Colla, Michael/G-1458-2010
OI Heuser, Isabella/0000-0001-7075-1158
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NR 20
TC 162
Z9 184
U1 1
U2 7
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0033-3174
J9 PSYCHOSOM MED
JI Psychosom. Med.
PD MAR-APR
PY 2002
VL 64
IS 2
BP 274
EP 277
DI 10.1097/00006842-200203000-00010
PG 4
WC Psychiatry; Psychology; Psychology, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry; Psychology
GA 533VU
UT WOS:000174551600010
PM 11914443
DA 2025-06-11
ER

PT J
AU Becarevic, M
   Burgic, E
AF Becarevic, Munevera
   Burgic, Esad
TI Cardiovascular risk factors in Banovici coal mine miners
SO HEALTHMED
LA English
DT Article
DE cardiovascular risk; arterial hypertension; metabolical syndrome;
   depression; miners
ID HIGH-DENSITY-LIPOPROTEINS; METABOLIC SYNDROME; WAIST CIRCUMFERENCE;
   UNITED-STATES; NATIONAL-HEALTH; BLOOD-PRESSURE; GLOBAL BURDEN;
   PREVALENCE; DEPRESSION; DISEASE
AB Global cardiovascular risk is probability to suffer heart attack or stroke in certain period of life and it depends on risk factors (RF) such as metabolical factors (total cholesterol, HDL cholesterol, glucoses metabolism disturbance), some biological factors (blood pressure) and some life style factors (smoking, physical activity).
   The aim of this research is to determine the presence and tendency of certain cardio vascular (CV) risk factors (RF) as well as determination of hypertension prevalence, metabolical syndrome and depression among coal-miners in Banovici black coal mine.
   Materials and methods: epidemiological study was conducted on 492 miners actively involved in working in mine pits. The analasys covered the following values: blood pressure, height and weight, BMI, waist, concentrations of total cholesterol, HDL and LDL cholesterol, triglycerides, blood sugar, determination of smoking status along with depression score based on Beks' scale.
   According to NCEP ATP III criteria MS is defined. The results are as follows: 43.9% out of 492 testers have high blood pressure, 34,34% are with depression, 42,88% are with MS. The most frequent risk factors are high BMI (75,40%), high values of LDL-H (70,32%). The most of hypertensive miners had six (23,61%), and normotensive three (21,73%) risk factors.
   Conclusion: there is high prevalence of diagnosing from hypertension, metabolical syndrome and depression with expressed tendency of risk factors grouping with high BMI as the most frequent one along with the high values of LDL cholesterol.
C1 [Becarevic, Munevera] Publ Hlth Ctr Banovici, Dept Occupat Med, Banovici, Bosnia & Herceg.
   [Burgic, Esad] Publ Hlth Ctr Lukavac, Dept Lab Diagnost, Biochem Hematol Lab, Clin Internal Dis, Lukavac, Bosnia & Herceg.
RP Becarevic, M (corresponding author), Publ Hlth Ctr Banovici, Dept Occupat Med, Banovici, Bosnia & Herceg.
EM munevera.b@gmail.com
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NR 44
TC 0
Z9 1
U1 1
U2 2
PU DRUNPP-SARAJEVO
PI SARAJEVO
PA BOLNICKA BB, SARAJEVO, 71000, BOSNIA & HERCEG
SN 1840-2291
EI 1986-8103
J9 HEALTHMED
JI HealthMED
PY 2012
VL 6
IS 3
BP 1067
EP 1075
PG 9
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 926GK
UT WOS:000302819100053
DA 2025-06-11
ER

PT J
AU Park, SK
   Chung, Y
   Chang, YS
   Oh, CM
   Ryoo, JH
   Jung, JY
AF Park, Sung Keun
   Chung, Yeongu
   Chang, Yoosoo
   Oh, Chang-Mo
   Ryoo, Jae-Hong
   Jung, Ju Young
TI Longitudinal analysis for the risk of depression according to the
   consumption of sugar-sweetened carbonated beverage in non-diabetic and
   diabetic population
SO SCIENTIFIC REPORTS
LA English
DT Article
ID SOFT DRINK CONSUMPTION; METABOLIC SYNDROME; INDEX; QUESTIONNAIRE;
   METAANALYSIS; ASSOCIATION; FRUCTOSE; GLUCOSE; OBESITY; ADULTS
AB Studies have presented that high intake of sugar-sweetened carbonated beverage (SSCB) was more associated with the prevalence of depression. However, longitudinal evidence is still insufficient to identify whether the effect of SSCB on incident depression is independent of metabolic factors. Therefore, to evaluate the effect of SSCB consumption on the risk of depression, we analyzed the risk of depression according to the consumption of SSCB in 87,115 working aged Koreans who responded to Center for Epidemiologic Studies Depression (CES-D) scale. They were categorized into 5 groups by SSCB consumption based on one serving dose (200 ml) with never/almost never, < 1 serving/week, 1 <= serving/week < 3, 3 <= serving/week < 5, and 5 <= serving/week. During follow-up, CES-D >= 16 was determined as incident depressive symptom. Cox proportional hazards model was used to calculate the multivariable-adjusted hazard ratio (HR) and 95% confidence intervals (CI) for depressive symptom. In analysis for all study participants, the risk of depressive symptom significantly increased proportionally to SSCB consumption (never/ almost never: reference, < 1 serving/week: 1.12 [1.07-1.17], 1 <= similar to < 3 serving/week: 1.26 [1.19-1.33], 3 <= similar to < 5 serving/week: 1.32 [1.23-1.42], and >= 5 serving/week: 1.45 [1.33-1.59]). This association was identically observed in men, women, normal glycemic subgroup and prediabetes subgroup.
C1 [Park, Sung Keun; Chang, Yoosoo] Sungkyunkwan Univ, Kangbuk Samsung Hosp, Ctr Cohort Studies, Total Healthcare Ctr,Sch Med, Seoul, South Korea.
   [Chung, Yeongu] Sungkyunkwan Univ, Kangbuk Samsung Hosp, Dept Neurosurg, Sch Med, Seoul, South Korea.
   [Oh, Chang-Mo] Kyung Hee Univ, Sch Med, Dept Prevent Med, Seoul, South Korea.
   [Ryoo, Jae-Hong] Kyung Hee Univ, Sch Med, Dept Occupat & Environm Med, Seoul, South Korea.
   [Jung, Ju Young] Sungkyunkwan Univ, Kangbuk Samsung Hosp, Total Healthcare Ctr, Sch Med, 67 Sejong Daero, Seoul 04514, South Korea.
C3 Sungkyunkwan University (SKKU); Samsung Medical Center; Sungkyunkwan
   University (SKKU); Samsung Medical Center; Kyung Hee University; Kyung
   Hee University; Sungkyunkwan University (SKKU)
RP Jung, JY (corresponding author), Sungkyunkwan Univ, Kangbuk Samsung Hosp, Total Healthcare Ctr, Sch Med, 67 Sejong Daero, Seoul 04514, South Korea.
EM jjy0501@naver.com
RI Jung, Ju/L-1569-2019
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   Shi ZM, 2010, PUBLIC HEALTH NUTR, V13, P1073, DOI 10.1017/S1368980009993132
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NR 34
TC 1
Z9 1
U1 1
U2 2
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD AUG 9
PY 2023
VL 13
IS 1
AR 12901
DI 10.1038/s41598-023-40194-6
PG 8
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA O7LF4
UT WOS:001045574100012
PM 37558774
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Shin, D
   Pregenzer, G
   Gardin, JM
AF Shin, David
   Pregenzer, Gerard, Jr.
   Gardin, Julius M.
TI Erectile Dysfunction A Disease Marker for Cardiovascular Disease
SO CARDIOLOGY IN REVIEW
LA English
DT Review
DE erectile dysfunction; cardiovascular disease; coronary artery disease
ID CORONARY-ARTERY-DISEASE; RISK-FACTORS; SEXUAL DYSFUNCTION; METABOLIC
   SYNDROME; HEART-DISEASE; INTERNATIONAL INDEX; CARDIAC RISK; PREVALENCE;
   POPULATION; CALCIUM
AB Previous studies have shown an increased incidence of erectile dysfunction (ED) among patients diagnosed with cardiovascular disease (CVD). Both conditions, which may be a consequence of underlying endothelial dysfunction, share many risk factors such as hypertension, dyslipidemia, diabetes, depression, obesity, and cigarette smoking. Because vascular disturbance of the penile endothelium leads to ED, the possibility arises that ED may be an early indicator for systemic endothelial dysfunction and subsequent CVD. Recognizing ED as a disease marker for CVD may help to identify individuals at risk for having a premature cardiovascular event.
C1 [Shin, David] Hackensack Univ, Med Ctr, Dept Urol, Hackensack, NJ 07601 USA.
   [Pregenzer, Gerard, Jr.] Univ Med & Dent New Jersey, Newark, NJ 07103 USA.
   [Gardin, Julius M.] Hackensack Univ, Med Ctr, Dept Internal Med, Hackensack, NJ USA.
C3 Hackensack University Medical Center; Rutgers University System; Rutgers
   University New Brunswick; Rutgers University Biomedical & Health
   Sciences; Hackensack University Medical Center
RP Shin, D (corresponding author), Hackensack Univ, Med Ctr, Dept Urol, 360 Essex St,Ste 403, Hackensack, NJ 07601 USA.
EM dshin@humed.com
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NR 68
TC 58
Z9 66
U1 0
U2 7
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1061-5377
EI 1538-4683
J9 CARDIOL REV
JI Cardiol. Rev.
PD JAN-FEB
PY 2011
VL 19
IS 1
BP 5
EP 11
DI 10.1097/CRD.0b013e3181fb7eb8
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 690YB
UT WOS:000285045100002
PM 21135596
DA 2025-06-11
ER

PT J
AU De Fruyt, J
   Deschepper, E
   Audenaert, K
   Constant, E
   Floris, M
   Pitchot, W
   Sienaert, P
   Souery, D
   Claes, S
AF De Fruyt, Juergen
   Deschepper, Ellen
   Audenaert, Kurt
   Constant, Eric
   Floris, Michel
   Pitchot, William
   Sienaert, Pascal
   Souery, Daniel
   Claes, Stephan
TI Second generation antipsychotics in the treatment of bipolar depression:
   a systematic review and meta-analysis
SO JOURNAL OF PSYCHOPHARMACOLOGY
LA English
DT Review
DE Bipolar disorder; meta-analysis; depressive episode; placebo; second
   generation antipsychotics
ID OLANZAPINE-FLUOXETINE COMBINATION; WEEKLY SYMPTOMATIC STATUS;
   DOUBLE-BLIND; II DEPRESSION; OLANZAPINE/FLUOXETINE COMBINATION;
   QUETIAPINE MONOTHERAPY; METABOLIC SYNDROME; NATURAL-HISTORY; DISORDER;
   EFFICACY
AB Depressive symptoms and episodes dominate the course of bipolar disorder. However, the therapeutic armamentarium for bipolar depression is limited. Recent evidence points to the efficacy of second generation antipsychotics (SGAs) for the treatment of bipolar depression. We conducted a systematic review and meta-analysis of the efficacy and safety of SGAs (randomized, double-blind, placebo-controlled trials; used in monotherapy) in the treatment of adult patients with bipolar depression. Publication bias was corrected for by performing similar searches using the clinical trials register of the respective pharmaceutical companies, the Cochrane Database and ClinicalTrials.gov. Seven published papers were identified on the use of aripiprazole, olanzapine and quetiapine. Internal validity of the trials was fairly good, external validity only moderate. Different outcome measures of efficacy and safety were assessed. When the individual trials were looked at, quetiapine and to a lesser extent olanzapine demonstrated significant improvement in MADRS (Montgomery-Asberg Depression Rating Scale) total scores. This was not demonstrated for aripiprazole. Efficacy was hampered by adverse events, such as weight gain, akathisia and somnolence/sedation. Both clinical heterogeneity of the included trials and statistical heterogeneity of the meta-analytic data were considerable. The number of quetiapine trials was disproportionate to the number of trials of aripiprazole and olanzapine. Further research is needed to assess differential efficacy of the different SGAs and their use in clinical practice.
C1 [De Fruyt, Juergen] Gen Hosp Sint Jan Brugge Oostende AV, Dept Psychiat, B-8000 Brugge, Belgium.
   [De Fruyt, Juergen; Claes, Stephan] Catholic Univ Louvain, Univ Psychiat Ctr, B-3000 Louvain, Belgium.
   [Deschepper, Ellen] Univ Ghent, Belgium Biostat Unit, B-9000 Ghent, Belgium.
   [Deschepper, Ellen] Univ Ghent, Dept Appl Math Biometr & Proc Control, B-9000 Ghent, Belgium.
   [Deschepper, Ellen; Audenaert, Kurt] Univ Ghent, Dept Psychiat & Med Psychol, B-9000 Ghent, Belgium.
   [Constant, Eric] Catholic Univ Louvain, Dept Psychiat, Woluwe St Lambert, Belgium.
   [Floris, Michel] Hop Notre Dame de Bon Secours, Dept Psychiat, Tournai, Belgium.
   [Pitchot, William] Univ Liege, Dept Psychiat, CHU Liege, Liege, Belgium.
   [Sienaert, Pascal] Katholieke Univ Leuven, Univ Psychiat Ctr, Kortenberg, Belgium.
   [Souery, Daniel] Univ Libre Bruxelles, Lab Psychol Med, Brussels, Belgium.
   [Souery, Daniel] Psy Pluriel European Ctr Psychol Med, Uccle, Belgium.
C3 Universite Catholique Louvain; Ghent University; Ghent University; Ghent
   University; Universite Catholique Louvain; University of Liege; KU
   Leuven; Universite Libre de Bruxelles
RP De Fruyt, J (corresponding author), Gen Hosp Sint Jan Brugge Oostende AV, Dept Psychiat & Psychosomat, Ruddershove 10, B-8000 Brugge, Belgium.
EM jurgendefruyt@skynet.be
RI Sienaert, Pascal/K-1838-2012
OI Claes, Stephan/0000-0002-1175-492X; Sienaert, Pascal/0000-0002-0650-415X
FU AstraZeneca Belgium; AstraZeneca; Boehringer Ingelheim; BristolMyers
   Squibb; Eli Lilly and Company; GlaxoSmithKline; JanssenCilag; Lundbeck;
   Pfizer; Servier; Wyeth; Nycomed; Solvay; Novartis; Fonds de la Recherche
   Scientifique; European Commission; Johnson Johnson
FX Funding for this meta-analysis was provided by AstraZeneca
   Belgium.Jurgen De Fruyt has been a consultant for, received honoraria or
   scientific/educational grant from, or conducted clinical research
   supported by the following: AstraZeneca, Boehringer Ingelheim,
   BristolMyers Squibb, Eli Lilly and Company, GlaxoSmithKline,
   JanssenCilag, Lundbeck, Pfizer, Servier and Wyeth.Michel Floris has been
   a consultant for, received honoraria or scientific/educational grant
   from, or conducted clinical research supported by the following:
   AstraZeneca, Eli Lilly and Company, Janssen-Cilag, Lundbeck and
   Nycomed.William Pitchot has been a consultant for, received honoraria or
   scientific/educational grant from, or conducted clinical research
   supported by the following: AstraZeneca, Bristol-Myers Squibb, Eli Lilly
   and Company, GlaxoSmithKline, Janssen-Cilag, Lundbeck, Novartis, Pfizer,
   Servier, Solvay and Wyeth.Daniel Souery has been a consultant for,
   received honoraria or scientific/educational grant from, or conducted
   clinical research supported by the following: AstraZeneca, Bristol-Myers
   Squibb, Janssen-Cilag, Lundbeck, Fonds de la Recherche Scientifique and
   European Commission.Stephan Claes has been a consultant for, received
   honoraria or scientific/educational grant from, or conducted clinical
   research supported by the following: AstraZeneca, Bristol-Myers Squibb,
   Eli Lilly and Company, Johnson & Johnson, GlaxoSmithKline and Wyeth.
   Stephan Claes is a Senior Clinical Investigator of the Fund for
   Scientific Research - Flanders (FWO - Vlaanderen).
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NR 48
TC 72
Z9 77
U1 0
U2 18
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0269-8811
EI 1461-7285
J9 J PSYCHOPHARMACOL
JI J. Psychopharmacol.
PD MAY
PY 2012
VL 26
IS 5
BP 603
EP 617
DI 10.1177/0269881111408461
PG 15
WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA 950PZ
UT WOS:000304662500002
PM 21940761
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Jahrami, H
   Saif, Z
   AlHaddad, M
   Faris, MA
   Hammad, L
   Ali, B
AF Jahrami, Haitham
   Saif, Zahra
   AlHaddad, Muntadher
   Faris, Mo'ez Al-Islam
   Hammad, Laila
   Ali, Batool
TI Assessing dietary and lifestyle risk behaviours and their associations
   with disease comorbidities among patients with depression: A case
   -control study from Bahrain
SO HELIYON
LA English
DT Article
DE Biological sciences; Health sciences; Cardiovascular disease;
   Depression; Dietary habits; Lifestyle behaviors; Physical activity;
   Smoking
ID INFLAMMATORY INDEX; SEDENTARY BEHAVIOR; BIPOLAR DISORDER; METABOLIC
   SYNDROME; MENTAL-ILLNESS; METAANALYSIS; SYMPTOMS; PEOPLE; PREVALENCE;
   SCHIZOPHRENIA
AB Objectives: In Western populations, patients with depression die 10 -25 years prematurely compared to controls, mainly due to lifestyle -related diseases. Tobacco smoking, excessive alcohol intake, poor diets and physical inactivity are among the major contributors to disease comorbidities. The objective of this research is to assess the dietary and lifestyle behaviours for Bahraini patients with depression and to determine their associations with different medical comorbidities. Methods: A case -control study was conducted from March to December 2019. A sample of 96 diagnosed patients with depression was recruited from the Psychiatric Hospital/Bahrain, and 96 age- and sex -matched controls were recruited from primary health centres. Assessment of anthropometrics, dietary and alcohol intakes, tobacco smoking and physical activity levels were undertaken for both cases and controls. National electronic medical records were reviewed retrospectively for medical comorbidities for the recruited cases. Logistic regression analysis was used to identify associations between lifestyle behaviours and medical comorbidities after controlling for confounding factors. Results: Patients with depression reported higher intakes of energy and energy -yielding macronutrients (e.g., carbohydrates, protein, and fat); three -fold higher rates of tobacco smoking; and signi ficantly lower levels of physical activity. Cases appeared to be at a doubled risk for developing obesity, diabetes type 2, hypertension, and musculoskeletal disorders. The risk for cardiovascular problems was similar for cases and controls. Conclusions: Poor dietary intakes, increased prevalence of smoking, and low levels of physical activity were evident in patients with depression in Bahrain; these factors were associated with some medical comorbidities.
C1 [Jahrami, Haitham; Saif, Zahra; AlHaddad, Muntadher; Hammad, Laila; Ali, Batool] Minist Hlth, Manama, Bahrain.
   [Jahrami, Haitham] Arabian Gulf Univ, Coll Med & Med Sci, Manama, Bahrain.
   [Faris, Mo'ez Al-Islam] Univ Sharjah, Res Inst Med & Hlth Sci RIMHS, Dept Clin Nutr & Dietet, Coll Hlth Sci, Sharjah, U Arab Emirates.
C3 Ministry of Health - Bahrain; Arabian Gulf University; University of
   Sharjah
RP Jahrami, H (corresponding author), Minist Hlth, Manama, Bahrain.; Jahrami, H (corresponding author), Arabian Gulf Univ, Coll Med & Med Sci, Manama, Bahrain.
EM hjahrami@health.gov.bh
RI Jahrami, Haitham/JVO-6632-2024; Faris, MoezAlIslam/M-9682-2017
OI Faris, MoezAlIslam/0000-0002-7970-2616; Jahrami,
   Haitham/0000-0001-8990-1320
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NR 62
TC 7
Z9 7
U1 0
U2 9
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
EI 2405-8440
J9 HELIYON
JI Heliyon
PD JUN
PY 2020
VL 6
IS 6
AR e04323
DI 10.1016/j.heliyon.2020.e04323
PG 11
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA MG1KU
UT WOS:000545792600037
PM 32637706
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Miller, LJ
   Ghadiali, NY
   Larusso, EM
   Wahlen, KJ
   Avni-Barron, O
   Mittal, L
   Greene, JA
AF Miller, Laura J.
   Ghadiali, Nafisa Y.
   Larusso, Elizabeth M.
   Wahlen, Kelly J.
   Avni-Barron, Orit
   Mittal, Leena
   Greene, Judy A.
TI Bipolar Disorder in Women
SO HEALTH CARE FOR WOMEN INTERNATIONAL
LA English
DT Article
ID MENSTRUAL-CYCLE PHASE; NATIONAL EPIDEMIOLOGIC SURVEY; MAJOR DEPRESSIVE
   DISORDER; GENDER-DIFFERENCES; SEX-DIFFERENCES; POSTPARTUM PSYCHOSIS;
   LITHIUM MAINTENANCE; UNIPOLAR DEPRESSION; INCREASED FREQUENCY;
   COMORBIDITY SURVEY
AB This article summarizes research pertinent to the clinical care of women with bipolar disorder. With bipolar disorder, female gender correlates with more depressive symptoms and different comorbidities. There is a high risk of symptom recurrence postpartum and possibly during perimenopause. Women with bipolar disorder have increased risk of sexually transmitted diseases, unplanned pregnancies, excessive weight gain, metabolic syndrome, and cardiovascular disease. Mood stabilizing medications, specific psychotherapies, and lifestyle changes can stabilize mood and improve functioning. Pharmacologic considerations include understanding interactions between mood stabilizing medications and contraceptive agents and risks and benefits of mood stabilizing medication during pregnancy and lactation.
C1 [Miller, Laura J.; Ghadiali, Nafisa Y.] Edward Hines Jr VA Hosp, Loyola Stritch Sch Med, Dept Psychiat, Hines, IL 60141 USA.
   [Larusso, Elizabeth M.] Abbott NW Hosp, Allina Mental Hlth, Minneapolis, MN 55407 USA.
   [Wahlen, Kelly J.] Milwaukee Cty Behav Hlth Div, Milwaukee, WI USA.
   [Avni-Barron, Orit; Mittal, Leena] Harvard Univ, Sch Med, Dept Psychiat, Boston, MA 02115 USA.
   [Mittal, Leena] Brigham & Womens Hosp, Dept Psychiat, Brookline, MA USA.
   [Greene, Judy A.] Bellevue Hosp Ctr, Div Psychiat, Womens Mental Hlth, New York, NY 10016 USA.
C3 US Department of Veterans Affairs; Veterans Health Administration (VHA);
   Edward Hines Jr. VA Hospital; Loyola University Chicago; Harvard
   University; Harvard Medical School; Harvard University; Harvard
   University Medical Affiliates; Brigham & Women's Hospital; Bellevue
   Hospital Center
RP Miller, LJ (corresponding author), Edward Hines Jr VA Hosp, Loyola Stritch Sch Med, Dept Psychiat, 5000 S 5th Ave,Bldg 228,Room 1016, Hines, IL 60141 USA.
EM Laura.Miller8@va.gov
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NR 112
TC 20
Z9 21
U1 1
U2 22
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 0739-9332
EI 1096-4665
J9 HEALTH CARE WOMEN IN
JI Health Care Women Int.
PD APR 3
PY 2015
VL 36
IS 4
BP 475
EP 498
DI 10.1080/07399332.2014.962138
PG 24
WC Public, Environmental & Occupational Health; Women's Studies
WE Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; Women's Studies
GA CF1QO
UT WOS:000352322900009
PM 25315819
DA 2025-06-11
ER

PT J
AU Shahanoor, Z
   Sultana, R
   Baker, MR
   Romeo, RD
AF Shahanoor, Ziasmin
   Sultana, Razia
   Baker, Madelyn R.
   Romeo, Russell D.
TI Neuroendocrine stress reactivity of male C57BL/6N mice following chronic
   oral corticosterone exposure during adulthood or adolescence
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE Adolescence; Oral-corticosterone; Paraventricular nucleus; Plasma
   corticosterone
ID METABOLIC SYNDROME; STEROID-HORMONES; FEMALE RATS; PUBERTY; BRAIN;
   RESPONSES; AXIS
AB Adolescence is associated with the maturation of the hypothalamic-pituitary-adrenal (HPA) axis, the major neuroendocrine axis mediating the hormonal stress response. Adolescence is also a period in development marked by a variety of stress-related vulnerabilities, including psychological and physiological dysfunctions. Many of these vulnerabilities are accompanied by a disrupted HPA axis. In adult mice, a model of disrupted HPA function has been developed using oral chronic corticosterone administration via the drinking water, which results in various physiological and neurobehavioral abnormalities, including changes in stress reactivity and anxiety-like behaviors. In an effort to further complement and extend this model, we tested the impact of HPA disruption in adolescent mice. We also examined whether this disruption led to different outcomes depending on whether the treatment happened during adolescence or adulthood. In the current set of experiments, we exposed adult (70 days of age) or adolescent (30 days of age) male C57BL/6N mice to 4 weeks of either 0 or 25 mu g/m1 oral corticosterone via their drinking water. We measured body weight during treatment and plasma corticosterone levels and activation of the paraventricular nucleus (PVN), as indexed by FOS immunohistochemistry, before and after a 30 min session of restraint stress. Our data indicate that adolescent animals exposed to chronic corticosterone showed weight loss during treatment, an effect not observed in adults. Further, we found stress failed to elevate plasma corticosterone levels in treated mice, regardless of whether exposure occurred in adulthood or adolescence. Despite this reduced hormonal responsiveness, we found significant neural activation in the PVN of both adult- and adolescent-treated mice, indicating a dissociation between stress-induced peripheral and central stress responses following chronic corticosterone exposure. Moreover, stress-induced neural activation in the PVN was unaffected by chronic corticosterone treatment in adult animals, but led to a hyper responsive PVN in the corticosterone-treated adolescent animals, suggesting an age-specific effect of corticosterone treatment on later PVN stress reactivity. Together, these experiments highlight the influence of developmental stage on somatic and neuroendocrine outcomes following chronic HPA disruption by noninvasive, oral corticosterone treatment. Given the substantial vulnerabilities to HPA dysfunctions during adolescence this model may prove useful in better understanding these vulnerabilities.
C1 [Romeo, Russell D.] Columbia Univ, Dept Psychol, Barnard Coll, New York, NY 10027 USA.
   Columbia Univ, Barnard Coll, Neurosci & Behav Program, New York, NY 10027 USA.
C3 Columbia University; Barnard College; Columbia University; Barnard
   College
RP Romeo, RD (corresponding author), Columbia Univ, Dept Psychol, Barnard Coll, New York, NY 10027 USA.
EM rromeo@barnard.edu
OI Baker, Madelyn/0000-0002-4231-1857
FU Faculty Research Grant from Barnard College
FX We would like to thank Page Buchanan for excellent animal care. This
   work was supported in part by a Faculty Research Grant from Barnard
   College.
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NR 31
TC 18
Z9 22
U1 0
U2 7
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD DEC
PY 2017
VL 86
BP 218
EP 224
DI 10.1016/j.psyneuen.2017.10.001
PG 7
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA FN1WG
UT WOS:000415781300026
PM 29020649
DA 2025-06-11
ER

PT J
AU Bernert, RA
   Luckenbaugh, DA
   Duncan, WC
   Iwata, NG
   Ballard, ED
   Zarate, CA
AF Bernert, Rebecca A.
   Luckenbaugh, David A.
   Duncan, Wallace C.
   Iwata, Naomi G.
   Ballard, Elizabeth D.
   Zarate, Carlos A.
TI Sleep architecture parameters as a putative biomarker of suicidal
   ideation in treatment-resistant depression
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Sleep architecture; Suicide risk; Depression; Bipolar disorder;
   Treatment-resistance
ID COGNITIVE-BEHAVIORAL THERAPY; BIPOLAR DISORDER; METABOLIC SYNDROME;
   MENTAL-DISORDERS; INSOMNIA; RISK; DISTURBANCE; HOPELESSNESS; SYMPTOMS;
   KETAMINE
AB Background: Disturbed sleep may confer risk for suicidal behaviors. Polysomnographic (PSG) sleep parameters have not been systematically evaluated in association with suicidal ideation (SI) among individuals with treatment-resistant depression (TRD).
   Methods: This secondary data analysis included 54 TRD individuals (N=30 with major depressive disorder (MDD) and N=24 with bipolar depression (BD)). PSG sleep parameters included Sleep Efficiency (SE), Total Sleep Time (TST), Wakefulness After Sleep Onset (WASO), REM percent/latency, and non-REM (NREM) Sleep Stages 1-4. The Hamilton Depression Rating Scale (HAM-D) was used to group participants according to presence or absence of SI. Sleep abnormalities were hypothesized among those with current SI. ANOVA analyses were conducted before (Model 1) and after adjusting for depression (Model 2) and diagnostic variables (Model 3).
   Results: Significant differences in PSG parameters were observed in Model 1; those with SI had less NREM Stage 4 sleep (p <.05). After adjusting for central covariates, Models 2 and 3 revealed significantly less NREM Stage 4 sleep, lower SE (P <.05), and higher WASO (P <.05) among those with SI. BD participants with SI also had less NREM Stage 4 and more NREM Stage 1 sleep.
   Limitations: 1) a predominantly white sample; 2) exclusion of imminent suicide risk; 3) concomitant mood stabilizer use among BD patients; and 4) single-item SI assessment.
   Conclusions: Independent of depression severity, SI was associated with less NREM Stage 4 sleep, and higher nocturnal wakefulness across diagnostic groups. Sleep may warrant further investigation in the pathogenesis of suicide risk, particularly in TRD, where risk may be heightened.
C1 [Bernert, Rebecca A.; Iwata, Naomi G.] Stanford Univ, Sch Med, Dept Psychiat & Behav Sci, Suicide Prevent Res Lab, Stanford, CA 94305 USA.
   [Luckenbaugh, David A.; Duncan, Wallace C.; Ballard, Elizabeth D.; Zarate, Carlos A.] NIMH, Expt Therapeut & Pathophysiol Branch, Intramural Res Program, NIH, Bethesda, MD 20892 USA.
C3 Stanford University; National Institutes of Health (NIH) - USA; NIH
   National Institute of Mental Health (NIMH)
RP Bernert, RA (corresponding author), Stanford Univ, Sch Med, Dept Psychiat & Behav Sci, Suicide Prevent Res Lab, Stanford, CA 94305 USA.
EM rbernert@stanford.edu
RI Zarate, Carlos/ABD-6843-2021; Ballard, Elizabeth/O-6856-2017
OI Ballard, Elizabeth/0000-0001-5304-0127
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NR 72
TC 56
Z9 59
U1 0
U2 26
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD JAN 15
PY 2017
VL 208
BP 309
EP 315
DI 10.1016/j.jad.2016.08.050
PG 7
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA EG0OR
UT WOS:000390732600045
PM 27810712
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Glass, DC
   Contrada, RJ
AF Glass, David C.
   Contrada, Richard J.
TI Bipolar disorder, Type A behaviour and coronary disease
SO HEALTH PSYCHOLOGY REVIEW
LA English
DT Article
DE bipolar disorder; Type A behaviour; depression; coronary heart disease
ID CARDIOVASCULAR RISK-FACTORS; HEART-DISEASE; LIFE EVENTS; METABOLIC
   SYNDROME; ARTERY-DISEASE; I-DISORDER; FOLLOW-UP; EPIDEMIOLOGIC EVIDENCE;
   DEPRESSIVE SYMPTOMS; GENERAL-POPULATION
AB This paper presents a model for integrating two psychological constructs - bipolar disorder and the Type A behaviour pattern - each of which has been associated with enhanced risk of coronary heart disease (CHD). It describes similarities between manic/hypomanic behaviours associated with bipolarity and the behaviours observed in Type A individuals. The proposed model highlights the importance of alternating patterns of coping with challenging and stressful life events. Thus, initial coping efforts are manifested as behavioural hyper-reactivity (i.e., Type A behaviours and mania/hypomania), but this gives way to hypo-reactivity (including helplessness and depression) after repeated failure to assert control and/or attain relevant goals. This alternation of what originally were regarded as Type A coping patterns resembles the affective and behavioural transitions often seen in bipolar patients. Future research on psychological, epidemiological and pathophysiological issues concerning CHD should document areas of commonality and independence between bipolarity and Type A behaviour. Such studies would benefit from consideration of a model that identifies psychosocial dimensions common to Type A, mania/hypomania and depression.
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C3 Rutgers University System; Rutgers University New Brunswick; State
   University of New York (SUNY) System; Stony Brook University
RP Contrada, RJ (corresponding author), Rutgers State Univ, Dept Psychol, 53 Ave E,Tillett Hall,Livingston Campus, Piscataway, NJ 08854 USA.
EM contrada@rci.rutgers.edu
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NR 84
TC 3
Z9 3
U1 0
U2 20
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND
SN 1743-7199
J9 HEALTH PSYCHOL REV
JI Health Psychol. Rev.
PY 2012
VL 6
IS 2
BP 180
EP 196
DI 10.1080/17437199.2010.531568
PG 17
WC Psychology, Clinical
WE Social Science Citation Index (SSCI)
SC Psychology
GA 975SA
UT WOS:000306530100004
DA 2025-06-11
ER

PT J
AU Gonçalves, RA
   Wijesekara, N
   Fraser, PE
   De Felice, FG
AF Goncalves, Rafaella Araujo
   Wijesekara, Nadeeja
   Fraser, Paul E.
   De Felice, Fernanda G.
TI Behavioral Abnormalities in Knockout and Humanized Tau Mice
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Article
DE Alzheimer's disease; MAPT; Tau protein; insulin; anxiety; metabolism;
   memory
ID MICROTUBULE-ASSOCIATED PROTEIN; MILD COGNITIVE IMPAIRMENT;
   DEPRESSIVE-LIKE BEHAVIOR; AMYLOID-BETA OLIGOMERS; INSULIN-RESISTANCE;
   ALZHEIMERS-DISEASE; METABOLIC SYNDROME; DEFICITS; RISK; SYMPTOMS
AB Microtubule-associated protein tau assists in stabilizing microtubules and has been particularly implicated in Alzheimer's disease (AD). Given the importance of tau to AD pathogenesis and therapies, it is important to understand non-classic physiological functions for this protein inside and outside the central nervous system (CNS). Our group has previously shown that tau ablation triggers glucose intolerance and pancreatic dysfunction in mice, suggesting that tau plays a role in peripheral metabolic regulation. Little is known about the role of tau in anxiety. Moreover, inconsistent results have been generated regarding the effects of tau deletion in memory. Here, we characterize systemic insulin resistance, anxiety-related behavior and memory in 15 to 20 weeks old Wild-Type (WT), Tau knockout (TauKO) and a distinct hTau mouse model consisting of tau knockout expressing the longest isoform (2N4R) of a non-mutant WT human Tau protein under the prion promoter (hTau). Our findings demonstrate that tau deletion leads to anxiety-related behavior, impaired contextual and cued fear memory. The presence of a human Tau transgene did not ameliorate the phenotypes observed in animals lacking the mouse tau protein and it elicited impairments in learning, memory, and peripheral insulin sensitivity. Our results suggest that tau protein plays a role in memory and anxiety-related behavior. Our findings also indicate that previously unrecognized functions for tau protein may be a complicating factor in using animal models on the TauKO background. Understanding the link between tau pathophysiology and cognitive and metabolic alterations is of great importance to establish the complete contribution of tau protein to AD pathogenesis.
C1 [Goncalves, Rafaella Araujo; De Felice, Fernanda G.] Queens Univ, Ctr Neurosci Studies, Kingston, ON, Canada.
   [Goncalves, Rafaella Araujo; Wijesekara, Nadeeja; Fraser, Paul E.] Univ Toronto, Tanz Ctr Res Neurodegenerat Dis, Toronto, ON, Canada.
   [Fraser, Paul E.] Univ Toronto, Dept Med Biophys, Toronto, ON, Canada.
   [De Felice, Fernanda G.] Queens Univ, Dept Psychiat, Kingston, ON, Canada.
   [De Felice, Fernanda G.] Univ Fed Rio de Janeiro, Inst Med Biochem Leopoldo de Meis, Rio De Janeiro, Brazil.
C3 Queens University - Canada; University of Toronto; University of
   Toronto; Queens University - Canada; Universidade Federal do Rio de
   Janeiro
RP De Felice, FG (corresponding author), Queens Univ, Ctr Neurosci Studies, Kingston, ON, Canada.; Fraser, PE (corresponding author), Univ Toronto, Tanz Ctr Res Neurodegenerat Dis, Toronto, ON, Canada.; Fraser, PE (corresponding author), Univ Toronto, Dept Med Biophys, Toronto, ON, Canada.; De Felice, FG (corresponding author), Queens Univ, Dept Psychiat, Kingston, ON, Canada.; De Felice, FG (corresponding author), Univ Fed Rio de Janeiro, Inst Med Biochem Leopoldo de Meis, Rio De Janeiro, Brazil.
EM paul.fraser@utoronto.ca; felice@bioqmed.ufrj.br
RI Wijesekara, Nadeeja/AAW-7230-2021; De Felice, Fernanda/M-1074-2017
OI WIJESEKARA, NADEEJA/0000-0001-5298-9779; Araujo Goncalves,
   Rafaella/0000-0001-5334-0816
FU Canadian Institutes of Health Research (CIHR) [MOP-115056]; Alzheimer
   Society of Ontario; Alzheimer's Society Canada; Weston Brain Institute,
   National Institute for Translational Neuroscience (INNT/Brazil)
   [465346/2014-6]; Conselho Nacional de Desenvolvimento Cientifico e
   Tecnologico (CNPq) [473324/2013-0]; Fundacao de Amparo a Pesquisa do
   Estado do Rio de Janeiro (FAPERJ) [202.944/2015]; Diabetes Canada
FX Work from PF laboratory was supported by grants from Canadian Institutes
   of Health Research (CIHR) (MOP-115056) and the Alzheimer Society of
   Ontario. Work from FD laboratory was supported by grants from
   Alzheimer's Society Canada and the Weston Brain Institute, National
   Institute for Translational Neuroscience (INNT/Brazil) (465346/2014-6),
   and the Brazilian funding agencies Conselho Nacional de Desenvolvimento
   Cientifico e Tecnologico (CNPq) (473324/2013-0) and Fundacao de Amparo a
   Pesquisa do Estado do Rio de Janeiro (FAPERJ) (202.944/2015). NW was
   supported by a postdoctoral fellowship from Diabetes Canada.
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NR 79
TC 31
Z9 34
U1 0
U2 3
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD MAR 12
PY 2020
VL 11
AR 124
DI 10.3389/fendo.2020.00124
PG 13
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA LD0CZ
UT WOS:000525702500001
PM 32226410
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU He, ZB
   Yin, GC
   Li, QQ
   Zeng, QF
   Duan, JL
AF He, Zubin
   Yin, Guochao
   Li, Qingdi Quentin
   Zeng, Qiongfang
   Duan, Jinliang
TI Diabetes Mellitus Causes Male Reproductive Dysfunction: A Review of the
   Evidence and Mechanisms
SO IN VIVO
LA English
DT Review
DE Diabetes mellitus; male fertility; male sexual dysfunction; male
   reproductive dysfunction; influencing mechanism; review
ID INSULIN-RESISTANCE; TESTOSTERONE; THERAPY; DAMAGE; GIRLS; RISK; GNRH;
   MEN
AB The metabolic disorders caused by diabetes can lead to various complications, including dysfunction of the male reproductive system. In patients with diabetes, long-term hyperglycemia results in diabetic vascular neuropathy, oxidative stress injury, abnormal zinc metabolism, and insulin resistance syndrome. In addition, insulin deficiency and resistance in diabetes can damage the hypothalamus, pituitary gland, gonads, and perigonads. This can reduce the secretion of sex hormones including gonadotropin-releasing hormone, follicle stimulating hormone, luteinizing hormone, and testosterone, and can lead to testicular atrophy, stromal cell atrophy, seminiferous tubule damage, spermatogenic cell damage, and other structural injuries of the male reproductive organs. These actions can affect male fertility and reproductive health. Herein, we review studies that report a causative role of diabetes in male reproductive function. We also discuss the evidence-based mechanisms involved in the processes of diabetes-related male sexual and reproductive dysfunction as well as the progress in treatment.
C1 [He, Zubin; Zeng, Qiongfang; Duan, Jinliang] 924 Hosp PLA Joint Logist Support Force, 1 Xinqiaoyuan Rd, Guilin 541002, Peoples R China.
   [Yin, Guochao] Guilin Rehabil & Recuperat Ctr, Guilin, Peoples R China.
   [Li, Qingdi Quentin] NIEHS, Sci Review Branch, Div Extramural Res & Training, NIH, Durham, NC USA.
C3 National Institutes of Health (NIH) - USA; NIH National Institute of
   Environmental Health Sciences (NIEHS)
RP Duan, JL (corresponding author), 924 Hosp PLA Joint Logist Support Force, 1 Xinqiaoyuan Rd, Guilin 541002, Peoples R China.
EM dj16342@21can.com
FU Guilin Scientific Research and Technology Development Plan [17js008]; 
   [20180106-4-7]
FX This work was supported by a grant for Omics evaluation and high
   precision genetic screening of embryo implantation potential in officers
   and soldiers of the PLA (No. 17js008) and a grant by Guilin Scientific
   Research and Technology Development Plan (No. 20180106-4-7). The Authors
   would also like to thank Diane Cooper, NIH Library, for reviewing the
   article.
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NR 46
TC 56
Z9 62
U1 0
U2 29
PU INT INST ANTICANCER RESEARCH
PI ATHENS
PA EDITORIAL OFFICE 1ST KM KAPANDRITIOU-KALAMOU RD KAPANDRITI, PO BOX 22,
   ATHENS 19014, GREECE
SN 0258-851X
EI 1791-7549
J9 IN VIVO
JI In Vivo
PD SEP-OCT
PY 2021
VL 35
IS 5
BP 2503
EP 2511
DI 10.21873/invivo.12531
PG 9
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA UC8AR
UT WOS:000686745300001
PM 34410936
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Yu, ZQ
   Bai, XY
   Ruan, GC
   Han, W
   Yang, H
AF Yu, Ziqing
   Bai, Xiaoyin
   Ruan, Gechong
   Han, Wei
   Yang, Hong
TI Association between generalized anxiety disorder and live microbes
   intake in the United States general population
SO CURRENT PSYCHOLOGY
LA English
DT Article
DE Generalized anxiety disorder; Live microbes; Anxiety; Dietary
ID METABOLIC SYNDROME; PROBIOTICS; PREBIOTICS
AB Generalized Anxiety Disorder (GAD) is the most common anxiety disorder in primary care, affecting approximately 7% of US adults. Probiotics have been found to alleviate symptoms in GAD, but the relationship between dietary live microbes and GAD remains unclear. Our aim is to determine the relationship between the dietary live microbe consumption and GAD. We included 54 GAD patients from the National Health and Nutrition Examination Survey and selected controls using a 1:4 propensity score matching. The diagnosis of GAD was based on the fourth edition of the American Psychiatric Association's Diagnostic and Statistical Manual of Mental Disorders. The live microbe intake was calculated based on expert-specified estimates of food [low (Lo), < 104 CFU/g; medium (Med), 104-107 CFU/g; or high (Hi), > 107 CFU/g].We observed a significant reduction in Med foods intake among GAD patients compared with controls (OR: 0.44, CI: 0.21-0.92, p = 0.03), also lower household income. Additionally, higher intake of Med foods correlated with a lower risk of GAD in males (OR: 0.26, CI: 0.08-0.84, p = 0.03), individuals with <= High school education (OR: 0.37, CI: 0.14-0.95, p = 0.04), non-hypertensive participants (OR: 0.37, CI: 0.16-0.87, p = 0.02), and drinkers (OR: 0.41, CI: 0.19-0.89, p = 0.03). Consuming more Med foods like fruits and vegetables may be a protective factor for GAD and could aid in future dietary management. Additionally, GAD patients require more financial and social support.
C1 [Yu, Ziqing; Bai, Xiaoyin; Ruan, Gechong; Yang, Hong] Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Gastroenterol, Beijing 100730, Peoples R China.
   [Han, Wei] Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Epidemiol & Biostat, Beijing 100730, Peoples R China.
C3 Chinese Academy of Medical Sciences - Peking Union Medical College;
   Peking Union Medical College Hospital; Peking Union Medical College;
   Chinese Academy of Medical Sciences - Peking Union Medical College;
   Peking Union Medical College; Peking Union Medical College Hospital
RP Yang, H (corresponding author), Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Gastroenterol, Beijing 100730, Peoples R China.
EM yangh@pumch.cn
RI Yu, Ziqing/JZD-6300-2024
FU Capital Health Research and Development of Special Foundation
FX No Statement Available
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NR 41
TC 0
Z9 0
U1 0
U2 3
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1046-1310
EI 1936-4733
J9 CURR PSYCHOL
JI Curr. Psychol.
PD SEP
PY 2024
VL 43
IS 35
BP 28342
EP 28351
DI 10.1007/s12144-024-06514-3
EA AUG 2024
PG 10
WC Psychology, Multidisciplinary
WE Social Science Citation Index (SSCI)
SC Psychology
GA G8M9E
UT WOS:001295795900002
DA 2025-06-11
ER

PT J
AU Shaffer, C
   Westlin, C
   Quigley, KS
   Whitfield-Gabrieli, S
   Barrett, LF
AF Shaffer, Clare
   Westlin, Christiana
   Quigley, Karen S.
   Whitfield-Gabrieli, Susan
   Barrett, Lisa Feldman
TI Allostasis, Action, and Affect in Depression: Insights from the Theory
   of Constructed Emotion
SO ANNUAL REVIEW OF CLINICAL PSYCHOLOGY
LA English
DT Article
DE metabolism; affect; emotion; interoception; predictive processing;
   allostasis; depression
ID FUNCTIONAL CONNECTIVITY; SIGNALING MECHANISMS; INSULIN-RESISTANCE;
   METABOLIC SYNDROME; NERVOUS-SYSTEM; RHESUS-MONKEY; BRAIN; MODEL; CORTEX;
   PERCEPTION
AB The theory of constructed emotion is a systems neuroscience approach to understanding the nature of emotion. It is also a general theoretical framework to guide hypothesis generation for how actions and experiences are constructed as the brain continually anticipates metabolic needs and attempts to meet those needs before they arise (termed allostasis). In this review, we introduce this framework and hypothesize that allostatic dysregulation is a trans-disorder vulnerability for mental and physical illness. We then review published findings consistent with the hypothesis that several symptoms in major depressive disorder (MDD), such as fatigue, distress, context insensitivity, reward insensitivity, and motor retardation, are associated with persistent problems in energy regulation. Our approach transforms the current understanding of MDD as resulting from enhanced emotional reactivity combined with reduced cognitive control and, in doing so, offers novel hypotheses regarding the development, progression, treatment, and prevention of MDD.
C1 [Shaffer, Clare; Westlin, Christiana; Quigley, Karen S.; Whitfield-Gabrieli, Susan; Barrett, Lisa Feldman] Northeastern Univ, Dept Psychol, Boston, MA 02115 USA.
   [Whitfield-Gabrieli, Susan] MIT, Dept Brain & Cognit Sci, E25-618, Cambridge, MA 02139 USA.
   [Barrett, Lisa Feldman] Massachusetts Gen Hosp, Dept Psychiat, Charlestown, MA USA.
   [Barrett, Lisa Feldman] Massachusetts Gen Hosp, Athinoula A Martinos Ctr Biomed Imaging, Charlestown, MA USA.
   [Barrett, Lisa Feldman] Harvard Med Sch, Charlestown, MA USA.
   [Quigley, Karen S.] VA Bedford Healthcare Syst, Bedford, MA USA.
C3 Northeastern University; Massachusetts Institute of Technology (MIT);
   Harvard University; Harvard University Medical Affiliates; Massachusetts
   General Hospital; Harvard University; Harvard University Medical
   Affiliates; Massachusetts General Hospital
RP Shaffer, C (corresponding author), Northeastern Univ, Dept Psychol, Boston, MA 02115 USA.
EM shaffer.c@northeastern.edu; l.barrett@northeastern.edu
RI Westlin, Christiana/LKO-3951-2024; Quigley, Karen/B-9003-2013; Barrett,
   Lisa/ABC-8157-2020
OI Westlin, Christiana/0000-0001-9127-0847; Shaffer,
   Clare/0000-0002-3977-6151; Barrett, Lisa/0000-0003-4478-2051
FU National Cancer Institute [U01CA193632]; National Institute of Mental
   Health [R01MH113234, R01MH109464]; National Institute on Aging
   [R56AG058745]; National Science Foundation [BCS1947972]; Elizabeth R.
   Koch Foundation; US Army Research Institute for the Behavioral and
   Social Sciences [W911NF-16-1-019]; National Institute of Mental Health
   [R01MH113234, R01MH109464] Funding Source: NIH RePORTER
FX The authors thank Nate McLaughlin and Francesca Morfini for their
   assistance in summarizing the neuroimaging and biomarker literature on
   depression. The writing of this review was supported by funding from the
   National Cancer Institute (U01CA193632), the National Institute of
   Mental Health (R01MH113234, R01MH109464), the National Institute on
   Aging (R56AG058745), the National Science Foundation (BCS1947972), and
   the Elizabeth R. Koch Foundation (through its Unlikely Collaborators
   Fund) to L.F.B. and by the US Army Research Institute for the Behavioral
   and Social Sciences (W911NF-16-1-019) to K.S.Q.
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NR 161
TC 40
Z9 43
U1 9
U2 51
PU ANNUAL REVIEWS
PI PALO ALTO
PA 4139 EL CAMINO WAY, PO BOX 10139, PALO ALTO, CA 94303-0139 USA
SN 1548-5943
EI 1548-5951
J9 ANNU REV CLIN PSYCHO
JI Annu. Rev. Clin. Psychol.
PY 2022
VL 18
BP 553
EP 580
DI 10.1146/annurev-clinpsy-081219-115627
PG 28
WC Psychology, Clinical; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology
GA 1L3PS
UT WOS:000799204400021
PM 35534123
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Hill, L
   Lee, KC
AF Hill, Lucas
   Lee, Kelly C.
TI Pharmacotherapy Considerations in Patients with HIV and Psychiatric
   Disorders: Focus on Antidepressants and Antipsychotics
SO ANNALS OF PHARMACOTHERAPY
LA English
DT Article
ID PLACEBO-CONTROLLED TRIAL; ANTIRETROVIRAL THERAPY; INFECTED PATIENTS;
   PHARMACOKINETIC INTERACTION; EXTRAPYRAMIDAL SYMPTOMS; NONMAJOR
   DEPRESSION; HEALTHY-VOLUNTEERS; POSITIVE PATIENTS; MAJOR DEPRESSION;
   AIDS PATIENTS
AB OBJECTIVE: To review the evidence for the efficacy and safety of pharmacologic agents for the treatment of depressive and psychotic disorders in patients with HIV infection and to provide clinical considerations for the treatment of depression and psychosis in these patients.
   DATA SOURCES: PubMed was searched for articles published between 1966 and August 1, 2012, using the search terms antiretrovirals, HIV, AIDS, depression, psychosis, schizophrenia, antidepressant, antipsychotic, and individual drug names (fluoxetine, sertraline, paroxetine, citalopram, escitalopram, venlafaxine, duloxetine, mirtazapine, bupropion, haloperidol, perphenazine, fluphenazine, aripiprazole, asenapine, clozapine, iloperidone, lurasidone, olanzapine, paliperidone, quetiapine, risperidone, ziprasidone).
   STUDY SELECTION AND DATA EXTRACTION: For the purposes of evaluating efficacy data, we limited our selection to randomized placebo-controlled or active comparator-controlled trials for agents that have been used for depression and psychosis in HIV-infected patients.
   DATA SYNTHESIS: We found 11 studies for depression treatment and 1 study for psychosis treatment that met our inclusion and exclusion criteria. Selective serotonin reuptake inhibitors (SSRIs; especially fluoxetine) and tricyclic antidepressants appear to be effective in treating depressive symptoms in patients with HIV infection without affecting immune status. Testosterone, stimulants, and dehydroepiandrosterone may also be effective in subsyndromal depression; however, studies on these agents in general were limited by small sample size. There are limited data for antipsychotics, with the only controlled study found for haloperidol and chlorpromazine used for AIDS delirium. Drug-drug interactions and potentiation of metabolic syndrome are concerns for the combined use of antidepressants and antipsychotics with antiretrovirals.
   CONCLUSIONS: Larger controlled studies are needed to validate the current findings as well as expand knowledge for non-SSRI antidepressants and second-generation antipsychotics for use in HIV-infected patients.
C1 [Hill, Lucas] Univ Calif San Diego, Med Ctr, La Jolla, CA 92093 USA.
   [Lee, Kelly C.] Univ Calif San Diego, Skaggs Sch Pharm & Pharmaceut Sci, La Jolla, CA 92093 USA.
C3 University of California System; University of California San Diego;
   University of California System; University of California San Diego
RP Lee, KC (corresponding author), Univ Calif San Diego, Skaggs Sch Pharm & Pharmaceut Sci, La Jolla, CA 92093 USA.
EM kellylee@ucsd.edu
RI Lee, Kelly/Q-9073-2018
OI Lee, Kelly/0000-0002-1674-4210
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NR 65
TC 42
Z9 47
U1 1
U2 25
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1060-0280
EI 1542-6270
J9 ANN PHARMACOTHER
JI Ann. Pharmacother.
PD JAN
PY 2013
VL 47
IS 1
BP 75
EP 89
DI 10.1345/aph.1R343
PG 15
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 225RX
UT WOS:000324981100016
PM 23341158
DA 2025-06-11
ER

PT J
AU Wagner, JA
   Tennen, H
   Mansoor, GA
   Abbott, G
AF Wagner, JA
   Tennen, H
   Mansoor, GA
   Abbott, G
TI History of major depressive disorder and endothelial function in
   postmenopausal women
SO PSYCHOSOMATIC MEDICINE
LA English
DT Article
DE depression; measurement; endothelial function; coronary heart disease;
   women; postmenopausal
ID FLOW-MEDIATED VASODILATION; R PSYCHIATRIC-DISORDERS; STRESSFUL LIFE
   EVENTS; C-REACTIVE PROTEIN; BRACHIAL-ARTERY; CORONARY; HEALTH; SYMPTOMS;
   VALIDITY; DISEASE
AB Objective: To determine whether history of depression is associated with endothelium-dependent flow-mediated dilation (FMD) in postmenopausal women. Methods: Thirty-nine postmenopausal women with no known or suspected cardiovascular disease participated. Nineteen had a positive lifetime history of major depressive disorder, and 20 were never depressed. None were currently depressed, and all had been free of major depressive disorder and antidepressant medications for >= 1 year. History of depression was assessed with the Structured Clinical Interview for DSM-IV, enhanced by a modified version of the timeline follow-back method. Current depressive symptoms were measured with the Center for Epidemiological Studies Depression scale (CES-D). Brachial artery FMD was measured with ultrasound and calculated as percent dilation from baseline. Results: After controlling for current subclinical depressive symptoms, ethnicity, hormone replacement therapy, and presence of the metabolic syndrome, previously depressed women showed significantly and clinically meaningful lower FMD than never depressed women. Controlling the same covariates, there was a dose-response relationship between number of depressive episodes and FMD. Examination of FMD means showed a significant negative correlation between number of depressive episodes and FMD. Conclusion: In postmenopausal women, depression continues to show a negative relationship to endothelial functioning even after years of remission. This relationship is not accounted for by residual depressive symptoms. Implications pertain to exclusion of previously depressed persons from control groups in research exploring the relationship between depression and cardiovascular disease. Key words: depression, measurement, endothelial function, coronary heart disease, women, postmenopausal.
C1 Univ Connecticut, Ctr Hlth, Dept Behav Sci & Community Hlth MC3910, Farmington, CT 06410 USA.
   Univ Connecticut, Ctr Hlth, Dept Community Hlth, Farmington, CT 06410 USA.
   Univ Connecticut, Ctr Hlth, Dept Med, Sect Hypertens, Farmington, CT 06410 USA.
C3 University of Connecticut; University of Connecticut; University of
   Connecticut
RP Univ Connecticut, Ctr Hlth, Dept Behav Sci & Community Hlth MC3910, 263 Farmington Ave, Farmington, CT 06410 USA.
EM juwagner@uchc.edu
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NR 68
TC 43
Z9 53
U1 0
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0033-3174
EI 1534-7796
J9 PSYCHOSOM MED
JI Psychosom. Med.
PD JAN-FEB
PY 2006
VL 68
IS 1
BP 80
EP 86
DI 10.1097/01.psy.0000195868.68122.9e
PG 7
WC Psychiatry; Psychology; Psychology, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry; Psychology
GA 006ZL
UT WOS:000234936500012
PM 16449415
DA 2025-06-11
ER

PT J
AU Bengtsson, I
   Lissner, L
   Ljung, T
   Rosengren, A
   Thelle, D
   Währborg, P
AF Bengtsson, Inger
   Lissner, Lauren
   Ljung, Thomas
   Rosengren, Annika
   Thelle, Dag
   Wahrborg, Peter
TI The cortisol awakening response and the metabolic syndrome in a
   population-based sample of middle-aged men and women
SO METABOLISM-CLINICAL AND EXPERIMENTAL
LA English
DT Article
ID PITUITARY-ADRENAL AXIS; ABDOMINAL OBESITY; SALIVA CORTISOL;
   SEX-DIFFERENCES; STRESS; WAKING; DEPRESSION; SECRETION; GENDER;
   INDIVIDUALS
AB The objective was to explore the relationship between the cortisol awakening response (CAR) and the metabolic syndrome (MetS) as defined by the National Cholesterol Education Program criteria. The final study sample consisted of 91 women (14 with MetS) and 84 men (15 with MetS), aged 45 to 70 years, from a general population sample. The only exclusion criteria were no consent, pregnancy, or insufficient cortisol testing. On the day of measurement (weekday), salivary cortisol was sampled at awakening and 15 minutes after awakening. Relative CAR (CAR%) and the MetS were the main variables studied. Results showed that, in women with the MetS, cortisol at awakening was significantly lower (mean, 8.92 vs 12.33 nmol/L; P = .05) and the CAR was significantly higher (91.4% vs 36.5%, P < .001) than in women without the syndrome. Significant difference in the relative CAR was also present between men and women with MetS (38.5% and 91.4%, respectively; P = .02). No difference was seen in the awakening response comparing men with and without the MetS. In a regression model, the response to awakening was dependent on the MetS in women (F-1,F-89 = 13.19, P < .001); but the model was not significant in men. Furthermore, the awakening response was associated with more depressive symptoms in women (F-1,F-80 = 8.12, P = .01) and with weekday/weekend cortisol sampling in men (F-1,F-82 = 4.63, P = .03). The association between the relative CAR and the MetS remained significant but somewhat attenuated after adjusting for depressive symptoms (P = .01). Results indicate a sex difference in the CAR% in the presence of the MetS independent of depressive symptoms, a known correlate of the MetS. (C) 2010 Elsevier Inc. All rights reserved.
C1 [Bengtsson, Inger] Univ Gothenburg, Dept Mol & Clin Med, Sahlgrenska Sch Publ Hlth & Community Med, Sahlgrenska Acad,Publ Hlth Epidemiol Unit EPI, Gothenburg, Sweden.
   Univ Gavle, Gavle, Sweden.
   Sahlgrens Univ Hosp, Dept Med, Gothenburg, Sweden.
   Univ Oslo, Inst Basic Med Sci, Dept Biostat, Oslo, Norway.
C3 University of Gothenburg; University of Gavle; Sahlgrenska University
   Hospital; University of Oslo
RP Bengtsson, I (corresponding author), Univ Gothenburg, Dept Mol & Clin Med, Sahlgrenska Sch Publ Hlth & Community Med, Sahlgrenska Acad,Publ Hlth Epidemiol Unit EPI, Gothenburg, Sweden.
EM ibengtsson@telia.com
RI Thelle, Dag/ABD-1867-2020
OI Thelle, Dag Steinar/0000-0002-4417-5967
FU Institute of Stress Medicine in Goteborg; Goteborg Medical Society;
   Local Research and Development Council of Goteborg and Southern
   Bohuslan; Swedish Heart and Lung Foundation; Swedish Council on Working
   Life and Social Research
FX This study was financially supported by grants from the Institute of
   Stress Medicine in Goteborg, the Goteborg Medical Society, the Local
   Research and Development Council of Goteborg and Southern Bohuslan, the
   Swedish Heart and Lung Foundation, and the Swedish Council on Working
   Life and Social Research.
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NR 45
TC 16
Z9 16
U1 0
U2 11
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0026-0495
EI 1532-8600
J9 METABOLISM
JI Metab.-Clin. Exp.
PD JUL
PY 2010
VL 59
IS 7
BP 1012
EP 1019
DI 10.1016/j.metabol.2009.10.024
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism
GA 611WH
UT WOS:000278854400012
PM 20045155
DA 2025-06-11
ER

PT J
AU Tsai, SF
   Hsu, PL
   Chen, YW
   Hossain, MS
   Chen, PC
   Tzeng, SF
   Chen, PS
   Kuo, YM
AF Tsai, Sheng-Feng
   Hsu, Pei-Ling
   Chen, Yun-Wen
   Hossain, Mohammad Shahadat
   Chen, Pei-Chun
   Tzeng, Shun-Fen
   Chen, Po-See
   Kuo, Yu-Min
TI High-fat diet induces depression-like phenotype via astrocyte-mediated
   hyperactivation of ventral hippocampal glutamatergic afferents to the
   nucleus accumbens
SO MOLECULAR PSYCHIATRY
LA English
DT Article
ID PROTEIN (GFAP)-IMMUNOREACTIVE ASTROCYTES; INDUCED UP-REGULATION;
   OPEN-LABEL TRIAL; METABOLIC SYNDROME; SOCIAL DEFEAT; DOUBLE-BLIND;
   DOPAMINE NEURONS; REWARD CIRCUIT; RAT-BRAIN; RILUZOLE
AB Comorbidity exists between metabolic disorders and depressive syndrome with unclear mechanisms. To characterize the causal relationship, we adopted a 12-week high-fat diet (HFD) to induce metabolic disorder and depressive phenotypes in mice. Initially, we identified an enhanced glutamatergic input in the nucleus accumbens of HFD mice. Retrograde tracing and chemogenetic inhibition showed that the hyperactive ventral hippocampal glutamatergic afferents to the nucleus accumbens determined the exhibition of depression-like behavior in HFD mice. Using lentiviral knockdown and overexpression approaches, we proved that HFD-induced downregulation of glial glutamate transporters, GLAST and GLT-1, contributed to the observed circuit maladaptations and subsequent depression-like behaviors. Finally, we identified a potential therapeutic agent, riluzole, which could mitigate the HFD-induced behavioral deficits by normalizing the expressions of GLAST and GLT-1 and ventral hippocampal glutamatergic afferents to the nucleus accumbens. Overall, astrocyte-mediated disturbance in glutamatergic transmission underlies the metabolic disorder-related depressive syndrome and represents a therapeutic target for this subtype of depressive mood disorders.
C1 [Tsai, Sheng-Feng; Hsu, Pei-Ling; Chen, Yun-Wen; Chen, Pei-Chun; Tzeng, Shun-Fen; Kuo, Yu-Min] Natl Cheng Kung Univ, Coll Med, Inst Basic Med Sci, Tainan 70101, Taiwan.
   [Tsai, Sheng-Feng; Hossain, Mohammad Shahadat; Kuo, Yu-Min] Natl Cheng Kung Univ, Coll Med, Dept Cell Biol & Anat, Tainan 70101, Taiwan.
   [Hsu, Pei-Ling; Chen, Pei-Chun] Natl Cheng Kung Univ, Coll Med, Dept Physiol, Tainan 70101, Taiwan.
   [Hsu, Pei-Ling] Kaohsiung Med Univ, Coll Med, Sch Med, Dept Anat, Kaohsiung 80708, Taiwan.
   [Chen, Yun-Wen] Natl Cheng Kung Univ, Coll Med, Dept Pharmacol, Tainan 70101, Taiwan.
   [Hossain, Mohammad Shahadat] Natl Cheng Kung Univ, Acad Sinica, Taiwan Int Grad Program, Interdisciplinary Neurosci, Tainan 70101, Taiwan.
   [Tzeng, Shun-Fen] Natl Cheng Kung Univ, Coll Biosci & Biotechnol, Dept Life Sci, Tainan 70101, Taiwan.
   [Chen, Po-See] Natl Cheng Kung Univ, Coll Med, Dept Psychiat, Tainan 70101, Taiwan.
   [Chen, Po-See] Natl Cheng Kung Univ, Natl Cheng Kung Univ Hosp, Addict Res Ctr, Tainan 70403, Taiwan.
C3 National Cheng Kung University; National Cheng Kung University; National
   Cheng Kung University; Kaohsiung Medical University; National Cheng Kung
   University; Academia Sinica - Taiwan; National Cheng Kung University;
   National Cheng Kung University; National Cheng Kung University; National
   Cheng Kung University; National Cheng Kung University Hospital
RP Kuo, YM (corresponding author), Natl Cheng Kung Univ, Coll Med, Inst Basic Med Sci, Tainan 70101, Taiwan.; Kuo, YM (corresponding author), Natl Cheng Kung Univ, Coll Med, Dept Cell Biol & Anat, Tainan 70101, Taiwan.
EM kuoym@mail.ncku.edu.tw
RI Hsu, Pei-Ling/HPH-5474-2023; Chen, Po/AAA-6492-2021; Sheng Feng,
   Tsai/HZM-0540-2023; Chen, Pei-Chun/K-8439-2019; Kuo, Yu-Min/A-9050-2013
OI Tsai, Sheng-Feng/0000-0001-5800-4280; Hsu, Pei-Ling/0000-0003-2035-8344;
   Kuo, Yu-Min/0000-0003-4867-2482; Hossain, Mohammad
   Shahadat/0000-0003-2660-8527
FU Ministry of Science and Technology, Taiwan [106-2320-B-006-049,
   107-2320-B-006-013, 108-2320-B-006-001, 109-2320-B-006-043-MY3,
   110-2320-B-006-021, 107-2811-B-006-532, 108-2811-B-006-533,
   109-2811-B-006-520, 110-2811-B-006-546]; Laboratory Animal Center,
   College of Medicine, National Cheng Kung University, Taiwan; Bioimaging
   Core Facility of the National Core Facility for Biopharmaceuticals,
   Ministry of Science and Technology, Taiwan; National Laboratory Animal
   Center, NARLabs, Taiwan; National RNAi Core Facility at Academia Sinica,
   Taiwan
FX We are grateful for the support and services from 1) Laboratory Animal
   Center, College of Medicine, National Cheng Kung University, Taiwan, 2)
   Bioimaging Core Facility of the National Core Facility for
   Biopharmaceuticals, Ministry of Science and Technology, Taiwan, 3)
   National Laboratory Animal Center, NARLabs, Taiwan, 4) National RNAi
   Core Facility at Academia Sinica, Taiwan. This project was funded by
   Ministry of Science and Technology, Taiwan (Grant #: 106-2320-B-006-049,
   107-2320-B-006-013, 108-2320-B-006-001, 109-2320-B-006-043-MY3,
   110-2320-B-006-021, 107-2811-B-006-532, 108-2811-B-006-533,
   109-2811-B-006-520, and 110-2811-B-006-546).
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NR 92
TC 28
Z9 28
U1 2
U2 28
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 1359-4184
EI 1476-5578
J9 MOL PSYCHIATR
JI Mol. Psychiatr.
PD NOV
PY 2022
VL 27
IS 11
BP 4372
EP 4384
DI 10.1038/s41380-022-01787-1
EA SEP 2022
PG 13
WC Biochemistry & Molecular Biology; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Neurosciences & Neurology; Psychiatry
GA 9B2MM
UT WOS:000862189700001
PM 36180573
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Ouanes, S
   Hashem, LA
   Makki, I
   Khan, F
   Mahgoub, O
   Wafer, A
   Dulaimy, O
   Amro, R
   Ghuloum, S
AF Ouanes, Sami
   Hashem, Lien Abou
   Makki, Ibrahim
   Khan, Faisal
   Mahgoub, Omer
   Wafer, Ahmed
   Dulaimy, Omer
   Amro, Raed
   Ghuloum, Suhaila
TI Mortality in Qatari individuals with mental illness: a retrospective
   cohort study
SO ANNALS OF GENERAL PSYCHIATRY
LA English
DT Article
DE Mortality; Mental illness; Death; Morbidity; Retrospective cohort
ID QUALITY-OF-CARE; CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME;
   PSYCHIATRIC-DISORDERS; DEPRESSIVE DISORDER; ANXIETY; PEOPLE; RISK;
   METAANALYSIS; PREVALENCE
AB Introduction There is substantial evidence that people with mental illness have higher mortality rates than the general population. However, most of the studies were from Western countries, and it is not clear whether this finding also applies to Arab countries like Qatar. Objectives We aimed to explore whether mortality in patients with mental illness in Qatar, is different from those without. Methods We conducted a retrospective cohort study, including all Qatari nationals deceased in 2017 and 2018, using the list of registered deaths from Hamad Medical Corporation (HMC) Mortuary. We divided the cohort of deceased people into two groups: with and without mental illness. For each of the groups, we collected the age at death, the reported cause of death as well as sociodemographic and clinical data. Results There were 602 registered deaths in 2017 and 589 deaths in 2018. The prevalence of mental illness was 20.4%. Compared to subjects without mental illness, subjects with mental illness surprisingly had higher age at death (median +/- IQR = 76.5 +/- 22.1 years vs. 62.7 +/- 32.9 years; p < .001). This difference persisted even after we controlled for covariates. Individuals with mental illness were more likely to die of an infection (OR = 1.98[1.44;2.71]), or of chronic respiratory disease (OR = 3.53 [1.66;7.52]) but less likely to die because of accidental (OR = 0.21[0.09;0.49]) or congenital causes (OR = 0.18[0.04;0.77]). Conclusion Contrary to most previous studies, we did not find that mortality was higher in Qatari individuals with mental illness. Sociocultural factors, free and easy-to-access healthcare, and an enhanced role of mental health professionals in detecting medical comorbidities may explain this finding.
C1 [Ouanes, Sami; Hashem, Lien Abou; Makki, Ibrahim; Khan, Faisal; Mahgoub, Omer; Wafer, Ahmed; Dulaimy, Omer; Amro, Raed; Ghuloum, Suhaila] Hamad Med Corp, Dept Psychiat, POB 3050, Doha, Qatar.
C3 Hamad Medical Corporation
RP Ghuloum, S (corresponding author), Hamad Med Corp, Dept Psychiat, POB 3050, Doha, Qatar.
EM sghuloum@hamad.qa
OI Makki, Ibrahim/0000-0001-8460-7616
FU Hamad Medical Corporation
FX We thank Dr. Hassan Hashem Elamin for his contribution to the data
   collection for this research project.
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NR 66
TC 0
Z9 0
U1 1
U2 1
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1744-859X
J9 ANN GEN PSYCHIATR
JI Ann. Gen. Psychiatr.
PD APR 18
PY 2024
VL 23
IS 1
AR 14
DI 10.1186/s12991-024-00499-w
PG 12
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA OE1O8
UT WOS:001205496300002
PM 38637811
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Andreu, Y
   Chiarugi, F
   Colantonio, S
   Giannakakis, G
   Giorgi, D
   Henriquez, P
   Kazantzaki, E
   Manousos, D
   Marias, K
   Matuszewski, BJ
   Pascali, MA
   Pediaditis, M
   Raccichini, G
   Tsiknakis, M
AF Andreu, Yasmina
   Chiarugi, Franco
   Colantonio, Sara
   Giannakakis, Giorgos
   Giorgi, Daniela
   Henriquez, Pedro
   Kazantzaki, Eleni
   Manousos, Dimitris
   Marias, Kostas
   Matuszewski, Bogdan J.
   Pascali, Maria Antonietta
   Pediaditis, Matthew
   Raccichini, Giovanni
   Tsiknakis, Manolis
TI Wize Mirror - a smart, multisensory cardio-metabolic risk monitoring
   system
SO COMPUTER VISION AND IMAGE UNDERSTANDING
LA English
DT Article
DE Unobtrusive health monitoring; 3D face detection; Tracking and
   reconstruction; 3D morphometric analysis; Psycho-somatic status
   recognition; Multimodal data integration
ID HEAD POSE ESTIMATION; FACE; ANXIETY; RECOGNITION; STRESS; ADULTS; SHAPE
AB In the recent years personal health monitoring systems have been gaining popularity, both as a result of the pull from the general population, keen to improve well-being and early detection of possibly serious health conditions and the push from the industry eager to translate the current significant progress in computer vision and machine learning into commercial products. One of such systems is the Wize Mirror, built as a result of the FP7 funded SEMEOTICONS (SEMEiotic Oriented Technology for Individuals CardiOmetabolic risk self-assessmeNt and Self-monitoring) project. The project aims to translate the semeiotic code of the human face into computational descriptors and measures, automatically extracted from videos, multispectral images, and 3D scans of the face. The multisensory platform, being developed as the result of that project, in the form of a smart mirror, looks for signs related to cardio-metabolic risks. The goal is to enable users to self-monitor their well-being status over time and improve their life-style via tailored user guidance. This paper is focused on the description of the part of that system. utilising computer vision and machine learning techniques to perform 3D morphological analysis of the face and recognition of psycho-somatic status both linked with cardio-metabolic risks. The paper describes the concepts, methods and the developed implementations as well as reports on the results obtained on both real and synthetic datasets. (C) 2016 The Authors. Published by Elsevier Inc.
C1 [Andreu, Yasmina; Henriquez, Pedro; Matuszewski, Bogdan J.] Univ Cent Lancashire, Sch Comp Engn & Phys Sci, Robot & Comp Vis Res Lab, Preston PR1 2HE, Lancs, England.
   [Colantonio, Sara; Giorgi, Daniela; Pascali, Maria Antonietta; Raccichini, Giovanni] Natl Res Council Italy, Inst Informat Sci & Technol, Via G Moruzzi 1, I-56124 Pisa, Italy.
   [Chiarugi, Franco; Giannakakis, Giorgos; Kazantzaki, Eleni; Manousos, Dimitris; Marias, Kostas; Pediaditis, Matthew; Tsiknakis, Manolis] Fdn Res & Technol Hellas FORTH, Inst Comp Sci, N Plastira 100, GR-70013 Iraklion, Crete, Greece.
   [Tsiknakis, Manolis] Technol Educ Inst Crete, Biomed Informat & eHlth Lab, GR-71004 Iraklion, Crete, Greece.
C3 University of Central Lancashire; Consiglio Nazionale delle Ricerche
   (CNR); Istituto di Scienza e Tecnologie dell'Informazione "Alessandro
   Faedo" (ISTI-CNR); Hellenic Mediterranean University
RP Colantonio, S (corresponding author), Natl Res Council Italy, Inst Informat Sci & Technol, Via G Moruzzi 1, I-56124 Pisa, Italy.
EM yasmina.andreu@gmail.com; sara.colantonio@isti.cnr.it
RI Giannakakis, Giorgos/V-5626-2019; Tsiknakis, Manolis/Z-2114-2019;
   Marias, Kostas/AAM-2330-2021; Pascali, Maria/AAU-5020-2020; Colantonio,
   Sara/AFL-2051-2022; GIORGI, DANIELA/B-3998-2017
OI GIORGI, DANIELA/0000-0002-6752-6918; Pascali, Maria
   Antonietta/0000-0001-7742-8126; Pediaditis, Matthew/0000-0003-2263-3020;
   COLANTONIO, SARA/0000-0003-2022-0804; Henriquez,
   Pedro/0000-0001-6582-5351; Tsiknakis, Manolis/0000-0001-8454-1450;
   Giannakakis, Giorgos/0000-0002-0958-5346; Marias,
   Kostas/0000-0003-3783-5223
FU European Community [611516]
FX This work has been supported by the European Community's Seventh
   Framework Programme (FP7/2013-2016) under the grant agreement number
   611516 (SEMEOTICONS). Thanks to the team from The Institute of Clinical
   Physiology of the National Research Council of Italy, namely Dr. Eng.
   Giuseppe Coppini, MD Paolo Marraccini and MD Maria-Aurora Morales, for
   their valuable collaboration in this work.
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NR 66
TC 30
Z9 41
U1 0
U2 18
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 1077-3142
EI 1090-235X
J9 COMPUT VIS IMAGE UND
JI Comput. Vis. Image Underst.
PD JUL
PY 2016
VL 148
BP 3
EP 22
DI 10.1016/j.cviu.2016.03.018
PG 20
WC Computer Science, Artificial Intelligence; Engineering, Electrical &
   Electronic
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Computer Science; Engineering
GA DP4GS
UT WOS:000378455000002
OA hybrid, Green Accepted
DA 2025-06-11
ER

PT J
AU Scannell, N
   Villani, A
   Moran, L
   Mantzioris, E
AF Scannell, Nicole
   Villani, Anthony
   Moran, Lisa
   Mantzioris, Evangeline
TI The potential role of the Mediterranean diet for the treatment and
   management of polycystic ovary syndrome: a review of the
   pathophysiological mechanisms and clinical evidence
SO PROCEEDINGS OF THE NUTRITION SOCIETY
LA English
DT Review; Early Access
DE Polycystic ovary syndrome; Mediterranean diet; Insulin resistance;
   Cardiometabolic; Reproductive; Psychological; Anti-inflammatory
ID POLYUNSATURATED FATTY-ACIDS; INSULIN-RESISTANCE; CARDIOVASCULAR-DISEASE;
   INFLAMMATORY PROCESSES; METABOLIC SYNDROME; DIABETES-MELLITUS; ANXIETY
   SYMPTOMS; CENTRAL OBESITY; MENTAL-HEALTH; SYNDROME PCOS
AB Polycystic ovary syndrome (PCOS) is a common endocrine disorder amongst reproductive-aged women associated with cardiometabolic, reproductive and psychological abnormalities. Lifestyle modification, including a healthy diet, is considered first-line treatment for management of clinical symptoms. However, there is limited high-quality evidence to support one superior therapeutic dietary intervention for PCOS management that is beyond general population-based dietary guidelines. Adherence to a Mediterranean diet (MedDiet) has been shown to decrease cardiometabolic disease risk and attenuate depressive symptoms, particularly in patients with metabolic perturbations. This narrative review summarises the proposed biological mechanisms underpinning the potential therapeutic benefits of a MedDiet for the management of cardiometabolic, reproductive and psychological features related to PCOS. Observational evidence suggests an inverse relationship between MedDiet adherence and PCOS features, particularly insulin resistance and hyperandrogenemia. Although the exact mechanisms are complex and multifaceted, they are likely related to the anti-inflammatory potential of the dietary pattern. These mechanisms are underpinned by anti-inflammatory bioactive constituents present in the MedDiet, including carotenoids, polyphenols and n-3 polyunsaturated fatty acids (PUFAs). Synthesis of the available literature suggests the MedDiet could be a promising therapeutic dietary intervention to attenuate short and long-term symptoms associated with PCOS and may aid in reducing the longer-term risks associated with cardiometabolic diseases and reproductive and psychological dysfunction. Nevertheless, current evidence remains insufficient to inform clinical practice and well-designed clinical trials are needed. As such, we provide recommendations for the design and delivery of future MedDiet interventions in women with PCOS, including exploring the acceptability, and feasibility to enhance adherence.
C1 [Scannell, Nicole; Villani, Anthony] Univ Sunshine Coast, Sch Hlth, Sippy Downs, Qld, Australia.
   [Moran, Lisa] Monash Univ, Monash Ctr Hlth Res & Implementat MCHRI, Sch Publ Hlth & Prevent Med, Melbourne, Vic, Australia.
   [Mantzioris, Evangeline] Univ South Australia, UniSA Clin & Hlth Sci, Alliance Res Exercise Nutr & Act ARENA, Adelaide, SA, Australia.
C3 University of the Sunshine Coast; Monash University; University of South
   Australia
RP Mantzioris, E (corresponding author), Univ South Australia, UniSA Clin & Hlth Sci, Alliance Res Exercise Nutr & Act ARENA, Adelaide, SA, Australia.
EM evangeline.mantzioris@unisa.edu.au
RI Moran, Lisa/E-9850-2015; Scannell, Nicole/ITU-5871-2023; Mantzioris,
   Evangeline/G-8681-2011
OI Mantzioris, Evangeline/0000-0002-1480-9869; Scannell,
   Nicole/0000-0002-2097-7631
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NR 184
TC 1
Z9 1
U1 3
U2 3
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0029-6651
EI 1475-2719
J9 P NUTR SOC
JI Proc. Nutr. Soc.
PD 2024 NOV 19
PY 2024
DI 10.1017/S0029665124007584
EA NOV 2024
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA O8G8P
UT WOS:001373454100001
PM 39558903
OA Bronze
DA 2025-06-11
ER

PT J
AU Stiglic, N
   Viner, RM
AF Stiglic, Neza
   Viner, Russell M.
TI Effects of screentime on the health and well-being of children and
   adolescents: a systematic review of reviews
SO BMJ OPEN
LA English
DT Review
ID SCHOOL-AGED CHILDREN; SEDENTARY BEHAVIOR; INDICATORS; VIOLENCE
AB Objectives To systematically examine the evidence of harms and benefits relating to time spent on screens for children and young people's (CYP) health and well-being, to inform policy.
   Methods Systematic review of reviews undertaken to answer the question 'What is the evidence for health and well-being effects of screentime in children and adolescents (CYP)?' Electronic databases were searched for systematic reviews in February 2018. Eligible reviews reported associations between time on screens (screentime; any type) and any health/well-being outcome in CYP. Quality of reviews was assessed and strength of evidence across reviews evaluated.
   Results 13 reviews were identified (1 high quality, 9 medium and 3 low quality). 6 addressed body composition; 3 diet/energy intake; 7 mental health; 4 cardiovascular risk; 4 for fitness; 3 for sleep; 1 pain; 1 asthma. We found moderately strong evidence for associations between screentime and greater obesity/adiposity and higher depressive symptoms; moderate evidence for an association between screentime and higher energy intake, less healthy diet quality and poorer quality of life. There was weak evidence for associations of screentime with behaviour problems, anxiety, hyperactivity and inattention, poorer self-esteem, poorer well-being and poorer psychosocial health, metabolic syndrome, poorer cardiorespiratory fitness, poorer cognitive development and lower educational attainments and poor sleep outcomes. There was no or insufficient evidence for an association of screentime with eating disorders or suicidal ideation, individual cardiovascular risk factors, asthma prevalence or pain. Evidence for threshold effects was weak. We found weak evidence that small amounts of daily screen use is not harmful and may have some benefits.
   Conclusions There is evidence that higher levels of screentime is associated with a variety of health harms for CYP, with evidence strongest for adiposity, unhealthy diet, depressive symptoms and quality of life. Evidence to guide policy on safe CYP screentime exposure is limited.
C1 [Stiglic, Neza; Viner, Russell M.] UCL Inst Child Hlth, Populat Policy & Practice Res Programme, London, England.
C3 University of London; University College London
RP Viner, RM (corresponding author), UCL Inst Child Hlth, Populat Policy & Practice Res Programme, London, England.
EM r.viner@ucl.ac.uk
RI Viner, Russell/A-1441-2009
OI Viner, Russell/0000-0003-3047-2247
CR [Anonymous], 2013, INT J BEHAV NUTR PHY, DOI DOI 10.1186/1479-5868-10-102
   [Anonymous], EVIDENCE POLICY
   [Anonymous], J PAEDIAT CHILD HLTH
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NR 27
TC 612
Z9 661
U1 36
U2 405
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2044-6055
J9 BMJ OPEN
JI BMJ Open
PD JUN
PY 2019
VL 9
IS 1
AR e023191
DI 10.1136/bmjopen-2018-023191
PG 15
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA IC6XU
UT WOS:000471116800085
PM 30606703
OA Green Published, gold
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Guo, YR
   Hsu, YH
   Liang, A
   Lu, WJ
   Wu, CH
   Lee, HC
   Huang, SY
AF Guo, Yu-Ru
   Hsu, Yi-Hao
   Liang, An
   Lu, Wan-Jung
   Wu, Chi-Hao
   Lee, Hsiu-Chuan
   Huang, Shih-Yi
TI n-3 Polyunsaturated fatty acids ameliorate cognitive age-related
   impairments and depressive behaviour in unchallenged aged prediabetic
   rats
SO JOURNAL OF FUNCTIONAL FOODS
LA English
DT Article
DE Fatty acid; Cognitive impairment; Depression
ID METABOLIC SYNDROME; DOCOSAHEXAENOIC ACID; INSULIN-RESISTANCE;
   DOUBLE-BLIND; RISK-FACTOR; OLD-AGE; BRAIN; OMEGA-3-FATTY-ACIDS;
   EXPRESSION; MEMORY
AB Epidemiological studies have reported that nutritional deficit of n-3 polyunsaturated fatty acids (PUFAs) is closely related to depression and cognitive impairment in middle and later life. This study investigated the preventive effects of n-3 PUFA-rich oils on the behavioural impairment of unchallenged aged prediabetic rats by using a Morris water maze (MWM) test and forced swimming test (FST). Twenty 102-wk-old male SD male rats received a 35% sucrose solution and were fed with fish oil or flaxseed oil diets for 8 wk. Both treatments reduced the production of IL-6 and non-esterified fatty acids significantly. Both treatments demonstrated significantly quicker MWM acquisition, shorter FST immobility time and higher levels of nerve growth factor than did the control group. Thus, n-3 PUFA-rich oil might produce protective effects by improving fasting blood sugar levels and reducing proinflammatory cytokine levels, thus preventing cognitive age-related impairments and depression-like behaviour in aged prediabetic rats. (C) 2015 Elsevier Ltd. All rights reserved.
C1 [Guo, Yu-Ru; Hsu, Yi-Hao; Liang, An; Lu, Wan-Jung; Wu, Chi-Hao; Lee, Hsiu-Chuan; Huang, Shih-Yi] Taipei Med Univ, Sch Nutr & Hlth Sci, Taipei 110, Taiwan.
C3 Taipei Medical University
RP Lee, HC (corresponding author), Taipei Med Univ, Sch Nutr & Hlth Sci, 250 Wu Xing St, Taipei 110, Taiwan.
EM joycelee@tmu.edu.tw; sihuang@tmu.edu.tw
RI Huang, Shih-Yi/R-3495-2018; Wu, chihao/G-3512-2011
OI Guo, Yu-Ru/0000-0003-0093-8368; Huang, Shih-Yi/0000-0003-2914-5513
FU Ministry of Science and Technology, Taiwan [NSC101-2320-B-038-020-MY2,
   NSC101-2811-B-038-006, NSC102-2313-B-038-003-MY2,
   MOST103-2320-B-038-012-MY3]
FX This study was partially supported by grants (NSC101-2320-B-038-020-MY2,
   NSC101-2811-B-038-006, NSC102-2313-B-038-003-MY2, and
   MOST103-2320-B-038-012-MY3) from the Ministry of Science and Technology,
   Taiwan.
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NR 91
TC 3
Z9 3
U1 1
U2 13
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1756-4646
EI 2214-9414
J9 J FUNCT FOODS
JI J. Funct. Food.
PD DEC
PY 2015
VL 19
BP 522
EP 536
DI 10.1016/j.jff.2015.09.050
PN A
PG 15
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA CX3XZ
UT WOS:000365634100049
OA hybrid
DA 2025-06-11
ER

PT J
AU Ramanathan, V
   Raj, DA
   Thekkumalai, M
AF Ramanathan, Veerappan
   Raj, Dominic Amal
   Thekkumalai, Malarvili
TI Macrotyloma uniflorum (Lam.) Verdc. improves glucose metabolism
   and proinflammatory parameters in high fructose fed rats
SO INDIAN JOURNAL OF EXPERIMENTAL BIOLOGY
LA English
DT Article
DE Adiponectin; Fructose diet; Glucocorticoid; Horsegram; Insulin
   resistance; Leptin; Mitochondrial enzymes
ID INSULIN-RESISTANCE SYNDROME; ADIPONECTIN; ANTIOXIDANT; EXPRESSION;
   AUTOPHAGY; ETIOLOGY; LEPTIN
AB Diabetes mellitus (DM) is the most common chronic metabolic disease and its complications constitute major health problems in heart, kidneys, eyes and nerves. The high fructose fed diet (HFFD) induces insulin resistance (IR), hyperinsulinaemia, hyperglycemia, alterations in lipid metabolism, and oxidative stress which plays a vital role in pathology associated with insulin resistance. Here, we explored the possible role of common pulse, horsegram (Macrotyloma uniflorum) as a therapeutic adjunct in a metabolic state of insulin resistance. Male adult Wistar strain albino rats (160-180 g) were divided into four groups of six rats in each. It is observed that the levels of Corticosterone (GC) and protein-bound sugars were higher and activities of liver mitochondrial enzymes were altered in HFFD rats, as compared to control animals. With the administered with M. uniflorum as adjunct in treatment of IR treatment which are functioned by increased GC in liver and adipose tissue and by stimulated liver mitochondrial enzymes activities and IR with reduce fructose.
C1 [Ramanathan, Veerappan] Enathi Rajappa Arts & Sci Coll, Dept Biochem, Pattukkottai, Tamil Nadu, India.
   [Raj, Dominic Amal] Adavan Arts & Sci Coll, Dept Biochem, Tiruchirappalli, Tamil Nadu, India.
   [Thekkumalai, Malarvili] Bharathidasan Univ, Constituents Coll, Thanjavur, Tamil Nadu, India.
C3 Bharathidasan University
RP Thekkumalai, M (corresponding author), Bharathidasan Univ, Constituents Coll, Thanjavur, Tamil Nadu, India.
EM drrmveera@gmail.com
RI Thekkumalai, Malarvili/CAJ-1151-2022
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NR 42
TC 1
Z9 1
U1 0
U2 0
PU NATL INST SCIENCE COMMUNICATION-NISCAIR
PI NEW DELHI
PA DR K S KRISHNAN MARG, PUSA CAMPUS, NEW DELHI 110 012, INDIA
SN 0019-5189
EI 0975-1009
J9 INDIAN J EXP BIOL
JI Indian J. Exp. Biol.
PD AUG
PY 2019
VL 57
IS 8
BP 594
EP 601
PG 8
WC Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics
GA JF8WU
UT WOS:000491665600005
DA 2025-06-11
ER

PT J
AU Abaj, F
   Esmaeily, Z
   Naeini, Z
   Rafiee, M
   Koohdani, F
AF Abaj, Faezeh
   Esmaeily, Zahra
   Naeini, Zeinab
   Rafiee, Masoumeh
   Koohdani, Fariba
TI Dietary acid load modifies the effects of ApoA2-265 T > C polymorphism
   on lipid profile and serum leptin and ghrelin levels among type 2
   diabetic patients
SO BMC ENDOCRINE DISORDERS
LA English
DT Article
DE APOA2-265 T > C polymorphism; T2DM; Nutrigenetic; Dietary acid load
ID APOLIPOPROTEIN-A-II; BODY-MASS INDEX; CARDIOMETABOLIC RISK-FACTORS;
   METABOLIC SYNDROME; REACTIVE PROTEIN; OXIDATIVE STRESS; FATTY-ACIDS;
   TRANSGENIC MICE; FOOD-INTAKE; BASE LOAD
AB This investigation with aimed the effect of APOA2-265 T > C polymorphism and dietary acid load (DAL) as either potential renal acid load (PRAL) and net endogenous acid production (NEAP) intake interaction on metabolic markers in type 2 diabetes mellitus (T2DM). In present cross-sectional study, 737 patients with T2DM (290 men and 447 women) were enlisted from diabetes centers in Tehran. The dietary intakes of all participants during the last year was acquired by a validated semi-quantitative food frequency (FFQ) questionnaire. Polymerase chain reaction (PCR) was used for genotyping the APOA2-265 T > C. Biochemical indises containing leptin, ghrelin, total cholesterol (Bailey et al., J Clin Invest 97:1147-1453, 1996), low-density lipoprotein cholestrol (LDL-C), high-density lipoprotein cholestrol (HDL-C), triglyceride (TG), superoxide dismutase (SOD), high sensitivy C-reactive protein (hs-CRP), total antioxidant capacity (TAC), pentraxin-3 (PTX3), prostaglandin F2 alpha (PGF2 alpha) and interleukin 18 (IL18) were measured by standard method. Atherogenic indices (AIP, AC, CR-I, CR-II) were calculated. The gene-diet interactions were evaluated using an GLM. The frequency overall prevalence of rs5082 genotypes was 63.82 and 36.17% for T-allele and C-allele respectively. TG, Ghrelin, and hs-CRP concentrations were significantly higher among carriers with C allele than TT homozygotes. However, TC/CC genotypes have lower PTX3 than TT homozygotes (P < 0.05). C-allele carriers had highest mean of BMI (P(NEAP=)0.04, P-PRAL = 0.006), WC (P(NEAP=)0.04, P-PRAL = 0.04), TC (P(NEAP=)0.03, P-PRAL = 0.01), ghrelin (P(NEAP=)0.01, P-PRAL = 0.04), and leptin (P(NEAP=)0.04, P-PRAL = 0.03) when placed in top tertiles of NEAP and PRAL.BMI, WC, TC, ghrelin, and leptin levels may be modified in C carriers by decreasing DAL, though, further investigations are required to confirm these findings.
C1 [Abaj, Faezeh; Esmaeily, Zahra] Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Community Nutr, Tehran, Iran.
   [Naeini, Zeinab; Koohdani, Fariba] Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Cellular & Mol Nutr, POB 141556117, Tehran, Iran.
   [Rafiee, Masoumeh] Isfahan Univ Med Sci, Sch Nutr & Food Sci, Dept Clin Nutr, Esfahan, Iran.
C3 Tehran University of Medical Sciences; Tehran University of Medical
   Sciences; Isfahan University of Medical Sciences
RP Koohdani, F (corresponding author), Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Cellular & Mol Nutr, POB 141556117, Tehran, Iran.; Rafiee, M (corresponding author), Isfahan Univ Med Sci, Sch Nutr & Food Sci, Dept Clin Nutr, Esfahan, Iran.
EM masomeh.rafiei@gmail.com; fkoohdan@tums.ac.ir
RI Abaj, Faezeh/ABA-8101-2021; Koohdani, Fariba/D-1298-2018; Rafiee,
   Masoumeh/AAC-8806-2019
OI Esmaeily, Zahra/0000-0003-0353-4457; Abaj, Faezeh/0000-0002-7841-2000
FU Tehran University of Medical Sciences [15061]
FX This work was supported by the Tehran University of Medical Sciences
   [grant number 15061].
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NR 96
TC 4
Z9 4
U1 0
U2 1
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1472-6823
J9 BMC ENDOCR DISORD
JI BMC Endocr. Disord.
PD JUL 26
PY 2022
VL 22
IS 1
AR 190
DI 10.1186/s12902-022-01083-7
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 3F5PP
UT WOS:000830721400001
PM 35883173
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Miedlich, SU
   Lamberti, JS
AF Miedlich, Susanne U.
   Lamberti, J. Steven
TI Connecting the dots: Understanding and addressing the metabolic impact
   of antipsychotic and antidepressant medications
SO ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
LA English
DT Review
DE antidepressant medications; antipsychotic medications; diabetes
   mellitus; effectiveness; mechanism of action; metabolic side effects;
   metabolic syndrome; obesity; psychotropic medications
ID MAJOR DEPRESSIVE DISORDER; LIFE-STYLE INTERVENTIONS; INDUCED
   WEIGHT-GAIN; SERIOUS MENTAL-ILLNESS; SCHIZOPHRENIA SPECTRUM DISORDERS;
   DIABETES-MELLITUS; BIPOLAR DISORDER; DOUBLE-BLIND; GLUCOSE-HOMEOSTASIS;
   SMOKING-CESSATION
AB Serious mental disorders such as schizophrenia and major depression are associated with considerable morbidity and mortality, resulting in much shorter life expectancies in those affected. The discovery of antipsychotic medications ushered in improved health outcomes for people with serious mental disorders but also brought about increased morbidity due to their metabolic side effects, including obesity and diabetes mellitus. Antidepressant medications have a more favorable metabolic side effect profile, but some can still cause weight gain and hyperglycemia. In this narrative review, we discuss antipsychotic and antidepressant medications' mechanisms of action, their respective effectiveness in treating psychosis and depression, and their metabolic side effects. In addition, we present therapeutic strategies for minimizing cardiometabolic health risks in patients treated with these medications by applying a comprehensive, biopsychosocial approach.
C1 [Miedlich, Susanne U.] Univ Rochester, Div Endocrinol, Med Ctr, Dept Med, Rochester, NY 14642 USA.
   [Lamberti, J. Steven] Univ Rochester, Med Ctr, Dept Psychiat, Rochester, NY USA.
C3 University of Rochester; University of Rochester
RP Miedlich, SU (corresponding author), Univ Rochester, Div Endocrinol, Med Ctr, Dept Med, Rochester, NY 14642 USA.
EM susanne_miedlich@urmc.rochester.edu
FU University of Rochester Medical Center; Department of Medicine of the
   University of Rochester Medical Center
FX S.U.M. has been supported by an award from the Department of Medicine of
   the University of Rochester Medical Center.
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NR 243
TC 0
Z9 0
U1 4
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0077-8923
EI 1749-6632
J9 ANN NY ACAD SCI
JI Ann. N.Y. Acad. Sci.
PD APR
PY 2025
VL 1546
IS 1
BP 35
EP 57
DI 10.1111/nyas.15301
EA MAR 2025
PG 23
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 1KK9X
UT WOS:001442466500001
PM 40072935
DA 2025-06-11
ER

PT J
AU Marcate-Chénard, A
   Deshayes, TA
   Ghachem, A
   Brochu, M
AF Marcate-Chenard, Alexis
   Deshayes, Thomas A.
   Ghachem, Ahmed
   Brochu, Martin
TI Prevalence of the metabolic syndrome between 1999 and 2014 in the United
   States adult population and the impact of the 2007-2008 recession: an
   NHANES study
SO APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
LA English
DT Article
DE metabolic syndrome; waist circumference; dietary intake; recession;
   hypertension; dyslipidemia
ID NUTRITION EXAMINATION SURVEY; 3RD NATIONAL-HEALTH; US ADULTS; ABDOMINAL
   OBESITY; PHYSICAL-ACTIVITY; CARDIOVASCULAR-DISEASE; TRENDS; RISK;
   GLUCOSE; ANXIETY
AB To document changes in prevalence of the metabolic syndrome (MetS) in the United States adult population between 1999 and 2014 and to explore how variations in the dietary intakes explain changes in MetS prevalence and its components over time. A total of 38 541 individuals (aged 20-85 years; National Health and Nutrition Examination Survey 1999-2014) were studied. Outcome variables were MetS, waist circumference (WC), plasma high-density lipoprotein cholesterol (HDL-c), triglycerides, fasting glucose (FG) levels, resting systolic and diastolic blood pressure, dietary intakes (total daily energy, carbohydrates, proteins, fats, sodium, and alcohol intakes), the poverty income ratio (PIR) and sociodemographic data (age, sex, ethnicity). Overall, the prevalence of the MetS significantly increased between 1999 and 2014 (27.9% to 31.5%). High plasma FG levels and high WC increased between 1999 and 2014, while the prevalence of the other components of MetS decreased or remained stable. Interestingly, a significant peak in MetS prevalence was observed in 2007-2008 compared with 1999-2006 (34.4% vs 27.6%), accompanied by a concomitant increase in WC and plasma FG levels, as well as a decrease in plasma HDL-c. Finally, significant decreases were observed for the PIR, total daily energy intake, sodium, and all macronutrient intakes in 2007-2008 compared with 1999-2006 (all P < 0.01). Results showed that the MetS prevalence significantly increased between 1999 and 2014 in the United States adult population, with a peak in 2007-2008. Interestingly, the 2007-2008 peak in MetS prevalence was accompanied by decreases in the PIR, total daily energy, and macronutrients intakes, suggesting potential impact of the 2007-2008 recession.
C1 [Marcate-Chenard, Alexis; Deshayes, Thomas A.; Ghachem, Ahmed; Brochu, Martin] Univ Sherbrooke, Fac Phys Act Sci, Sherbrooke, PQ J1K 2R1, Canada.
   [Marcate-Chenard, Alexis; Deshayes, Thomas A.; Ghachem, Ahmed; Brochu, Martin] Univ Inst Geriatr Sherbrooke, Social Serv & Hlth Ctr, Res Ctr Aging, Sherbrooke, PQ J1H 4C4, Canada.
C3 University of Sherbrooke; University of Sherbrooke
RP Brochu, M (corresponding author), Univ Sherbrooke, Fac Phys Act Sci, Sherbrooke, PQ J1K 2R1, Canada.; Brochu, M (corresponding author), Univ Inst Geriatr Sherbrooke, Social Serv & Hlth Ctr, Res Ctr Aging, Sherbrooke, PQ J1H 4C4, Canada.
EM Martin.brochu@usherbrooke.ca
RI Deshayes, Thomas/HKO-7594-2023
OI Deshayes, Thomas/0000-0002-7620-1939
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NR 43
TC 26
Z9 27
U1 0
U2 1
PU CANADIAN SCIENCE PUBLISHING
PI OTTAWA
PA 65 AURIGA DR, SUITE 203, OTTAWA, ON K2E 7W6, CANADA
SN 1715-5312
EI 1715-5320
J9 APPL PHYSIOL NUTR ME
JI Appl. Physiol. Nutr. Metab.
PD AUG
PY 2019
VL 44
IS 8
BP 861
EP 868
DI 10.1139/apnm-2018-0648
PG 8
WC Nutrition & Dietetics; Physiology; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics; Physiology; Sport Sciences
GA IM4CX
UT WOS:000477943400009
PM 30640516
DA 2025-06-11
ER

PT J
AU Xu, DR
   Gao, X
   Zhao, LB
   Liu, SD
   Tang, G
   Zhou, CJ
   Chen, Y
AF Xu, Di-Ru
   Gao, Xi
   Zhao, Li-Bo
   Liu, Shu-Dong
   Tang, Ge
   Zhou, Chan-Juan
   Chen, Yu
TI Association between triglyceride and depression: A systematic review and
   meta-analysis
SO PLOS ONE
LA English
DT Review
ID SERUM-LIPID CONCENTRATIONS; MAJOR DEPRESSION; CARDIOVASCULAR RISK;
   METABOLIC SYNDROME; CHOLESTEROL; DISORDER; WOMEN; PREVALENCE; MARKERS;
   HEALTH
AB Depression is accompanied by dyslipidemia, which may increase the risk of stroke and coronary heart disease. This study sought to quantitatively summarize the clinical data comparing peripheral blood triglyceride (TG) concentrations between patients with major depressive disorder (MDD) and healthy controls (HCs). Studies were searched in PubMed, EMBASE, PsycINFO, and Cochrane Databases up to March 2023. We also reviewed the reference lists of obtained articles. Mean (+/- SD) for TG concentrations were extracted, combined quantitatively using random-effects meta-analysis, and summarized as a standardized mean difference (SMD). Subgroup analysis and meta-regression was performed to explore the resource of heterogeneity. Thirty-eight studies measuring the concentrations of peripheral blood TG in 2604 patients with MDD and 3272 HCs were included. Meta-analysis results indicated that TG levels were significant higher in patients with MDD than in HCs (SMD = 0.31, 95% confidence interval [CI]: 0.16 to 0.46, Z(46) = 4.05, p < 0.01). Heterogeneity was detected (chi(2) = 269.97, p < 0.01, I-2 = 85%). Subgroup analysis demonstrated significant differences in TG levels between patients with MDD and HCs depended on age, body mass index and drug use (p < 0.05), but no differences between groups. Meta-regression also found no significant variables. TG level was significantly elevated in depression, which may explain the increased risk of cardiovascular and cerebrovascular events in depression.
C1 [Xu, Di-Ru; Gao, Xi] Chongqing Med Univ, Univ Town Hosp, Dept Dermatol, Chongqing, Peoples R China.
   [Zhao, Li-Bo; Liu, Shu-Dong; Tang, Ge] Chongqing Med Univ, Yongchuan Hosp, Dept Neurol, Chongqing, Peoples R China.
   [Zhao, Li-Bo; Liu, Shu-Dong; Tang, Ge; Zhou, Chan-Juan; Chen, Yu] Chongqing Key Lab Cerebrovasc Dis Res, Chongqing, Peoples R China.
   [Chen, Yu] Chongqing Med Univ, Dept Neurol, Bishan Hosp, Chongqing, Peoples R China.
C3 Chongqing Medical University; Chongqing Medical University; Chongqing
   Medical University
RP Chen, Y (corresponding author), Chongqing Key Lab Cerebrovasc Dis Res, Chongqing, Peoples R China.; Chen, Y (corresponding author), Chongqing Med Univ, Dept Neurol, Bishan Hosp, Chongqing, Peoples R China.
EM cheny@hospital.cqmu.edu.cn
RI Zhao, Libo/G-2421-2010
OI Chen, Yu/0000-0002-9682-4922
FU National Natural Science Foundation of China [81601207]
FX National Natural Science Foundation of China (Grant No. 81601207)/. The
   funder of <EM><STRONG> </STRONG></EM>Professor Li Bo Zhao had proofread
   the manuscript.
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NR 59
TC 2
Z9 2
U1 8
U2 11
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD OCT 4
PY 2024
VL 19
IS 10
AR e0311625
DI 10.1371/journal.pone.0311625
PG 15
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA I3N6T
UT WOS:001329362000042
PM 39365811
OA gold
DA 2025-06-11
ER

PT J
AU Oldenburg, J
AF Oldenburg, Jan
TI Hypogonadism and fertility issues following primary treatment or
   testicular cancer
SO UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
LA English
DT Review
DE Hypogonadism; Testosterone; Infertility; Testicular cancer;
   Subfertility; Cryopreservation; Accelerated ageing
ID LONG-TERM SURVIVORS; METABOLIC SYNDROME; SEXUAL FUNCTION;
   HORMONE-LEVELS; MEN; SPERMATOGENESIS; ORCHIECTOMY; INFERTILITY;
   POPULATION; RISK
AB Background: The majority of testicular cancer (TC) patients are cured and expected to live for decades after treatment, such that knowledge about hypogonadism and fertility issues is particularly important for the group of testicular cancer survivors (TCSs). Hypogonadism and fertility issues are related to treatment intensity.
   Methods: In order to give an overview about hypogonadism in testicular cancer survivors (TCSs) the literature was reviewed. Testicular dysfunction was defined as inadequate spemiatogenesis, as reflected by increased levels of Follicle Stimulating Hormone (FSH) and reduced fertility and/with or without insufficient testosterone (T) production with or without compensatory increased Luteinizing Hormone (LH) levels.
   Findings: Hypogonadism may lead to reduced sexual functioning and well-being, fertility problems, muscle weakness, loss of energy, and depression. Furthermore, hypogonadism also increases the risk of osteoporosis and is associated with the metabolic syndrome and cardiovascular disease (CVD). The hypothesized "Testicular Dysgenesis Syndrome" comprising low sperm counts, hypospadias, cryptorchidism, and finally TC, probably contributes to hypogonadism independent of applied TC treatment. Recently, an increased risk of accelerated hormonal ageing has been reported in TCSs in the very long term, i.e. 20 years after TC treatment. (C) 2015 Elsevier Inc. All rights reserved.
C1 Hgsk Buskerud & Vestfold, Hlth Sci, Kongsberg, Norway.
RP Oldenburg, J (corresponding author), Hgsk Buskerud & Vestfold, Hlth Sci, Kongsberg, Norway.
EM jan.oldenburg@medisin.uio.no
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NR 26
TC 15
Z9 15
U1 0
U2 11
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1078-1439
EI 1873-2496
J9 UROL ONCOL-SEMIN ORI
JI Urol. Oncol.-Semin. Orig. Investig.
PD SEP
PY 2015
VL 33
IS 9
BP 407
EP 412
DI 10.1016/j.urolonc.2015.01.014
PG 6
WC Oncology; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Urology & Nephrology
GA CR0TV
UT WOS:000361037000026
PM 25736189
DA 2025-06-11
ER

PT J
AU Schmitz, N
   Deschênes, SS
   Burns, RJ
   Danna, SM
   Franco, OH
   Ikram, MA
   Kivimäki, M
   Singh-Manoux, A
   Tiemeier, H
AF Schmitz, Norbert
   Deschenes, Sonya S.
   Burns, Rachel J.
   Danna, Sofia M.
   Franco, Oscar H.
   Ikram, M. Arfan
   Kivimaki, Mika
   Singh-Manoux, Archana
   Tiemeier, Henning
TI Cardiometabolic dysregulation and cognitive decline: potential role of
   depressive symptoms
SO BRITISH JOURNAL OF PSYCHIATRY
LA English
DT Article
ID INCREASED RISK; METABOLIC SYNDROME; DEMENTIA; DISEASE; ASSOCIATION;
   DISORDERS; METAANALYSIS; COMPONENTS; AGE
AB Background
   Previous studies have examined associations of cardiometabolic factors with depression and cognition separately.
   Aims
   To determine if depressive symptoms mediate the association between cardiometabolic factors and cognitive decline in two community studies.
   Method
   Data for the analyses were drawn from the Rotterdam Study, the Netherlands (n = 2940) and the Whitehall II study, UK (n = 4469).
   Results
   Mediation analyses suggested a direct association between cardiometabolic factors and cognitive decline and an indirect association through depression: poorer cardiometabolic status at time 1 was associated with a higher level of depressive symptoms at time 2 (standardised regression coefficient 0.07 and 0.06, respectively), which, in turn, was associated with greater cognitive decline between time 2 and time 3 (standardised regression coefficient of -0.15 and -0.41, respectively).
   Conclusions
   Evidence from two independent cohort studies suggest an association between cardiometabolic dysregulation and cognitive decline and that depressive symptoms tend to precede this decline.
C1 [Schmitz, Norbert; Deschenes, Sonya S.; Burns, Rachel J.] McGill Univ, Dept Psychiat, Montreal, PQ, Canada.
   [Schmitz, Norbert; Deschenes, Sonya S.; Burns, Rachel J.] Douglas Mental Hlth Univ Inst, Montreal, PQ, Canada.
   [Schmitz, Norbert] Montreal Diabet Res Ctr, Montreal, PQ, Canada.
   [Danna, Sofia M.] McGill Univ, Dept Epidemiol & Biostat, Montreal, PQ, Canada.
   [Franco, Oscar H.; Ikram, M. Arfan] Erasmus MC, Univ Med Ctr Rotterdam, Dept Epidemiol, Rotterdam, Netherlands.
   [Kivimaki, Mika; Singh-Manoux, Archana] UCL, Dept Epidemiol & Publ Hlth, London, England.
   [Singh-Manoux, Archana] Hop Paul Brousse, INSERM, Ctr Res Epidemiol & Populat Hlth, U1018, Villejuif, France.
   [Tiemeier, Henning] Erasmus MC, Univ Med Ctr Rotterdam, Dept Psychiat, Dept Epidemiol, Rotterdam, Netherlands.
   [Tiemeier, Henning] Erasmus MC, Univ Med Ctr Rotterdam, Dept Child & Adolescent Psychiat, Rotterdam, Netherlands.
C3 McGill University; Universite de Montreal; McGill University; Erasmus
   University Rotterdam; Erasmus MC; University of London; University
   College London; Universite Paris Saclay; Institut National de la Sante
   et de la Recherche Medicale (Inserm); Assistance Publique Hopitaux Paris
   (APHP); Hopital Universitaire Paul-Brousse - APHP; Erasmus University
   Rotterdam; Erasmus MC; Erasmus University Rotterdam; Erasmus MC
RP Schmitz, N (corresponding author), McGill Univ, Douglas Mental Hlth Univ Inst, 6875 LaSalle Blvd, Montreal, PQ H4H 1R3, Canada.
EM norbert.schmitz@mcgill.ca
RI Franco, Óscar/ABE-2305-2020; Tiemeier, Henning/H-6534-2019; Ikram,
   M./AAM-5225-2021; Kivimaki, Mika/B-3607-2012; Schmitz,
   Norbert/AAH-3624-2020; Deschenes, Sonya/G-6341-2017; Danna,
   Sofia/AFR-2563-2022; Singh-Manoux, Archana/F-6804-2013; Schmitz,
   Norbert/A-5177-2010
OI Danna, Sofia/0000-0003-4861-8400; Franco, Oscar/0000-0002-4606-4929;
   Singh-Manoux, Archana/0000-0002-1244-5037; Kivimaki,
   Mika/0000-0002-4699-5627; Deschenes, Sonya/0000-0002-9258-0895; Schmitz,
   Norbert/0000-0001-7777-6323
FU Erasmus Medical Center, Rotterdam; Netherlands Organization for the
   Health Research and Development (ZonMw); Research Institute for Diseases
   in the Elderly (RIDE); Ministry of Education, Culture and Science;
   Ministry for Health, Welfare and Sports; European Commission (DG XII);
   Municipality of Rotterdam; Medical Research Council [K013351]; National
   Institute on Aging [AG13196]; National Heart Lung and Blood Institute
   [HL36310]; British Heart Foundation; Erasmus University, Rotterdam; ESRC
   [ES/J023299/1] Funding Source: UKRI; MRC [MR/K013351/1] Funding Source:
   UKRI
FX The Rotterdam Study is funded by the Erasmus Medical Center and Erasmus
   University, Rotterdam, the Netherlands Organization for the Health
   Research and Development (ZonMw), the Research Institute for Diseases in
   the Elderly (RIDE), the Ministry of Education, Culture and Science, the
   Ministry for Health, Welfare and Sports, the European Commission (DG
   XII), and the Municipality of Rotterdam. Continuing data collection on
   the Whitehall II study is funded by the Medical Research Council
   (K013351), National Institute on Aging (AG13196), National Heart Lung
   and Blood Institute (HL36310) and the British Heart Foundation. No
   funding was received to complete the analysis and interpretation of data
   for this paper. The funding agencies had no role in the design or
   conduct of the study, in the collection, management, analysis, or
   interpretation of the data, or in the preparation, review, or approval
   of the manuscript.
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NR 44
TC 27
Z9 33
U1 1
U2 11
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1250
EI 1472-1465
J9 BRIT J PSYCHIAT
JI Br. J. Psychiatry
PD FEB
PY 2018
VL 212
IS 2
BP 96
EP 102
DI 10.1192/bjp.2017.26
PG 7
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA FU7IA
UT WOS:000424024500007
PM 29436332
OA Bronze, Green Submitted
DA 2025-06-11
ER

PT J
AU Floege, J
AF Floege, Juergen
TI Magnesium in CKD: more than a calcification inhibitor?
SO JOURNAL OF NEPHROLOGY
LA English
DT Review
DE Magnesium; Chronic kidney disease; Cardiovascular disease; Diabetes;
   Depression
ID CHRONIC KIDNEY-DISEASE; ISCHEMIC-HEART-DISEASE; VASCULAR SMOOTH-MUSCLE;
   CALCIUM ACETATE/MAGNESIUM CARBONATE; FIBROBLAST GROWTH FACTOR-23;
   INTIMA-MEDIA THICKNESS; STAGE RENAL-DISEASE; DIETARY MAGNESIUM; SERUM
   MAGNESIUM; CARDIOVASCULAR-DISEASE
AB Magnesium fulfils important roles in multiple physiological processes. Accordingly, a tight regulation of magnesium homeostasis is essential. Dysregulated magnesium serum levels, in particular hypomagnesaemia, are common in patients with chronic kidney disease (CKD) and have been associated with poor clinical outcomes. In cell culture studies as well as in clinical situations magnesium levels were associated with vascular calcification, cardiovascular disease and altered bone-mineral metabolism. Magnesium has also been linked to diseases such as metabolic syndrome, diabetes, hypertension, fatigue and depression, all of which are common in CKD. The present review summarizes and discusses the latest clinical data on the impact of magnesium and possible effects of higher levels on the health status of patients with CKD, including an outlook on the use of magnesium-based phosphate-binding agents in this context.
C1 Rhein Westfal TH Aachen, Div Nephrol & Clin Immunol, D-52057 Aachen, Germany.
C3 RWTH Aachen University
RP Floege, J (corresponding author), Rhein Westfal TH Aachen, Div Nephrol & Clin Immunol, Pauwelsstr 30, D-52057 Aachen, Germany.
EM juergen.floege@rwth-aachen.de
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NR 86
TC 37
Z9 38
U1 0
U2 21
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1121-8428
EI 1724-6059
J9 J NEPHROL
JI J. Nephrol.
PD JUN
PY 2015
VL 28
IS 3
BP 269
EP 277
DI 10.1007/s40620-014-0140-6
PG 9
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA CI6SW
UT WOS:000354892900002
PM 25227765
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Chen, C
   Chang, Z
   Kuja-Halkola, R
   D'Onofrio, BM
   Larsson, H
   Andell, P
   Lichtenstein, P
   Pettersson, E
AF Chen, Cen
   Chang, Zheng
   Kuja-Halkola, Ralf
   D'Onofrio, Brian M.
   Larsson, Henrik
   Andell, Pontus
   Lichtenstein, Paul
   Pettersson, Erik
TI Associations Between General and Specific Mental Health Conditions in
   Young Adulthood and Cardiometabolic Complications in Middle Adulthood: A
   40-Year Longitudinal Familial Coaggregation Study of 672,823 Swedish
   Individuals
SO AMERICAN JOURNAL OF PSYCHIATRY
LA English
DT Article
ID MAJOR DEPRESSIVE DISORDER; METABOLIC SYNDROME; CARDIOVASCULAR MORTALITY;
   BIPOLAR DISORDER; RISK; ANXIETY; LIFE; PSYCHOPATHOLOGY; SCHIZOPHRENIA;
   COMPONENTS
AB Objective: Most mental disorders, when examined individually, are associated with an increased risk of cardiometabolic complications. However, these associations might be attributed to a general liability to psychopathology or confounded by unmeasured familial factors. The authors investigated the association between psychiatric conditions in young adulthood and the risk of cardiometabolic complications in middle adulthood, up to 40 years later. Methods: This cohort study (N=672,823) identified all individuals and their siblings born in Sweden between 1955 and 1962 and followed the cohort through 2013. Logistic regression models were used to estimate the bivariate associations between 10 psychiatric conditions or criminal convictions and five cardiometabolic complications in individuals. A general factor model was used to identify general, internalizing, externalizing, and psychotic factors based on the comorbidity among psychiatric conditions and criminal convictions. The cardiometabolic complications were then regressed on the latent general factor and three uncorrelated specific factors within a structural equation modeling framework in individuals and across sibling pairs. Results: Each psychiatric condition significantly increased the risk of cardiometabolic complications. These associations appeared nonspecific, as multivariate models indicated that most were attributable to the general factor of psychopathology, rather than to specific psychiatric conditions. There were no or only small associations between individuals' general psychopathology and their siblings' cardiometabolic complications. The same pattern was evident for the specific internalizing and psychotic factors. Conclusions: Associations between mental disorders in early life and later long-term risk of cardiometabolic complications appeared to be attributable to a general liability to psychopathology. Familial coaggregation analyses suggested that the elevated risk could not be attributed to confounders shared within families. One possibility is that lifestyle-based interventions may reduce the risk of later cardiometabolic complications for patients with several mental disorders.
C1 [Chen, Cen; Chang, Zheng; Kuja-Halkola, Ralf; D'Onofrio, Brian M.; Larsson, Henrik; Lichtenstein, Paul; Pettersson, Erik] Karolinska Inst, Dept Med Epidemiol & Biostat, Solna, Sweden.
   [D'Onofrio, Brian M.] Indiana Univ, Dept Psychol & Brain Sci, Bloomington, IN USA.
   [Larsson, Henrik] Orebro Univ, Sch Med Sci, Orebro, Sweden.
   [Andell, Pontus] Karolinska Inst, Dept Med, Unit Cardiol, Stockholm, Sweden.
   [Andell, Pontus] Karolinska Univ Hosp, Heart & Vasc Div, Stockholm, Sweden.
C3 Karolinska Institutet; Indiana University System; Indiana University
   Bloomington; Orebro University; Karolinska Institutet; Karolinska
   Institutet; Karolinska University Hospital
RP Chen, C (corresponding author), Karolinska Inst, Dept Med Epidemiol & Biostat, Solna, Sweden.
EM cen.chen@ki.se
RI Kuja-Halkola, Ralf/ABA-5061-2020; Pettersson, Erik/AAH-2531-2020;
   Larsson, Henrik/GYD-5161-2022; Chang, Zheng/LBH-0831-2024; Andell,
   Pontus/ITU-4503-2023; Andell, Pontus/N-9979-2014
OI Andell, Pontus/0000-0002-2759-1379; Kuja-Halkola,
   Ralf/0000-0002-3765-2067
FU Swedish Research Council for Health [2017-01358]; Stockholm Region
   [20190712]; China Scholarship Council; Swedish Research Council
   [2017-01358] Funding Source: Swedish Research Council
FX Supported by the Swedish Research Council for Health (grant 2017-01358)
   , ALF Funding from the Stockholm Region (grant 20190712) , and the China
   Scholarship Council.
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NR 46
TC 3
Z9 3
U1 0
U2 10
PU AMER PSYCHIATRIC PUBLISHING, INC
PI WASHINGTON
PA 800 MAINE AVE SW, SUITE 900, WASHINGTON, DC 20024 USA
SN 0002-953X
EI 1535-7228
J9 AM J PSYCHIAT
JI Am. J. Psychiat.
PD JUL
PY 2024
VL 181
IS 7
BP 651
EP 657
DI 10.1176/appi.ajp.20220951
PG 7
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA A2G7A
UT WOS:001280771400016
PM 38263878
DA 2025-06-11
ER

PT J
AU Poggiogalle, E
   Di Lazzaro, L
   Pinto, A
   Migliaccio, S
   Lenzi, A
   Donini, LM
AF Poggiogalle, Eleonora
   Di Lazzaro, Luca
   Pinto, Alessandro
   Migliaccio, Silvia
   Lenzi, Andrea
   Donini, Lorenzo M.
TI Health-Related Quality of Life and Quality of Sexual Life in Obese
   Subjects
SO INTERNATIONAL JOURNAL OF ENDOCRINOLOGY
LA English
DT Article
ID BIOELECTRICAL-IMPEDANCE ANALYSIS; BODY-MASS INDEX; METABOLIC SYNDROME;
   EXTREME OBESITY; DYSFUNCTION; OVERWEIGHT; SATISFACTION; WEIGHT;
   ASSOCIATION; PREVALENCE
AB The increased prevalence of obesity represents, currently, one of the major public health issues, due to its consequences on physical and psychological health status as well as on the psychosocial functioning. As defined by the World Health Organization, sexual health is "a state of physical, emotional, mental, and social well-being in relation to sexuality." The aim of the present study was to explore the relationship between sexual life in obese subjects and quality of life, psychological status, and disability. Methods. 95 obese subjects were recruited from June 2012 to February 2013 and underwent physical examination and measures for the assessment of quality of life, sexual life, psychological status, and disability. Results. In obese subjects sexual life was related to gender, age, psychological status, disability, and quality of life. Conclusion. As obesity is a multifactorial disease, and is accompanied by multiple comorbidities, it is difficult to identify a single causative factor responsible for the impairment of sexual life in obese subjects; thus, a thorough, multidimensional evaluation including sexual function assessment should be performed in obese people.
C1 [Poggiogalle, Eleonora; Di Lazzaro, Luca; Pinto, Alessandro; Lenzi, Andrea; Donini, Lorenzo M.] Univ Roma La Sapienza, Dept Expt Med, Med Pathophysiol Food Sci & Endocrinol Sect, I-00185 Rome, Italy.
   [Migliaccio, Silvia] Univ Rome Foro Italico, Dept Movement Human & Hlth Sci, I-00195 Rome, Italy.
C3 Sapienza University Rome; Foro Italico University of Rome
RP Poggiogalle, E (corresponding author), Univ Roma La Sapienza, Dept Expt Med, Med Pathophysiol Food Sci & Endocrinol Sect, Piazzale Aldo Moro 5, I-00185 Rome, Italy.
EM eleonora.poggiogalle@gmail.com
RI Donini, Lorenzo/AAS-3873-2020; Poggiogalle, Eleonora/AAB-9338-2019;
   Lenzi, Andrea/I-7711-2015
OI Migliaccio, Silvia/0000-0002-4563-6630; Poggiogalle,
   Eleonora/0000-0003-0862-5892; Pinto, Alessandro/0000-0002-4864-2294;
   Donini, Lorenzo/0000-0003-4692-4754; Lenzi, Andrea/0000-0002-7711-0465
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NR 43
TC 21
Z9 25
U1 0
U2 12
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1687-8337
EI 1687-8345
J9 INT J ENDOCRINOL
JI Int. J. Endocrinol.
PY 2014
VL 2014
AR 847871
DI 10.1155/2014/847871
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism
GA AC6QU
UT WOS:000332650100001
PM 24707290
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU O'Sullivan, TA
   Schmidt, KA
   Kratz, M
AF O'Sullivan, Therese A.
   Schmidt, Kelsey A.
   Kratz, Mario
TI Whole-Fat or Reduced-Fat Dairy Product Intake, Adiposity, and
   Cardiometabolic Health in Children: A Systematic Review
SO ADVANCES IN NUTRITION
LA English
DT Review
DE dairy; low-Mt; regular-fat; skim milk; whole milk; children; pediatric;
   overweight; cholesterol
ID BODY-MASS INDEX; APOB/APOA-I RATIO; METABOLIC SYNDROME; MILK
   CONSUMPTION; CARDIOVASCULAR-DISEASE; MYOCARDIAL-INFARCTION; INVERSE
   ASSOCIATION; BEVERAGE PATTERNS; HDL-CHOLESTEROL; SATURATED FAT
AB Dietary guidelines commonly recommend that children aged >2 y consume reduced-fat dairy products rather than regular- or whole-Mt dairy. In adults, most studies have not found the consumption of whole-fat dairy products to be associated with increased cardiometabolic or adiposity risk. Associations in children could differ due to growth and development. We systematically reviewed the literature in indexed, peer-reviewed journals to summarize pediatric studies (children aged from 2 to 18 y) assessing associations between whole- and reduced-Mt dairy intake and measures of adiposity as well as biomarkers of cardiometabolic disease risk, including the serum lipid profile, blood pressure, low-grade chronic inflammation, oxidative stress, and measures of glucose homeostasis. For the purposes of this review, a "whole-fat" dairy product was defined as a product with the natural fat content, whereas a 'reduced-far dairy product was defined as a product with some or all of the fat removed (including "low-far and "skim" versions). A total of 29 journal articles met our criteria for inclusion. The majority were conducted in the United States and were prospective or cross-sectional observational studies, with only 1 randomized controlled trial. Studies were consistent in reporting that whole-fat dairy products were not associated with increased measures of weight gain or adiposity. Most evidence indicated that consumption of whole-Mt dairy was not associated with increased cardiometabolic risk, although a change from whole-Mt to reduced-Mt dairy improved outcomes for some risk factors in 1 study.Taken as a whole, the limited literature in this field is not consistent with dietary guidelines recommending that children consume preferably reduced-fat dairy products. High-quality randomized controlled trials in children that directly compare the effects of whole-fat compared with reduced-fat dairy intake on measures of adiposity or biomarkers of cardiometabolic disease risk are needed to provide better quality evidence in this area.
C1 [O'Sullivan, Therese A.] Edith Cowan Univ, Sch Med & Hlth Sci, Joondalup, WA, Australia.
   [Schmidt, Kelsey A.; Kratz, Mario] Fred Hutchinson Res Ctr, Div Publ Hlth Sci, Canc Prevent Program, Seattle, WA USA.
   [Kratz, Mario] Univ Washington, Dept Med, Div Metab Endocrinol & Nutr, Seattle, WA USA.
   [Kratz, Mario] Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA.
C3 Edith Cowan University; Fred Hutchinson Cancer Center; University of
   Washington; University of Washington Seattle; University of Washington;
   University of Washington Seattle
RP O'Sullivan, TA (corresponding author), Edith Cowan Univ, Sch Med & Hlth Sci, Joondalup, WA, Australia.
EM t.osullivan@ecu.edu.au
RI O'Sullivan, Therese/D-1723-2016
OI O'Sullivan, Therese/0000-0003-1003-854X; Kratz,
   Mario/0000-0003-2660-8033
FU NIH [T32 CA094880]; MRC [MC_PC_19009] Funding Source: UKRI
FX KAS was supported by grant number T32 CA094880 from the NIH.
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NR 98
TC 34
Z9 36
U1 2
U2 21
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 2161-8313
EI 2156-5376
J9 ADV NUTR
JI Adv. Nutr.
PD JUL
PY 2020
VL 11
IS 4
BP 928
EP 950
DI 10.1093/advances/nmaa011
PG 23
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA OX1PF
UT WOS:000593344900012
PM 32119732
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Watson, NA
   Dyer, KA
   Buckley, JD
   Brinkworth, GD
   Coates, AM
   Parfitt, G
   Howe, PRC
   Noakes, M
   Dye, L
   Chadwick, H
   Murphy, KJ
AF Watson, Nerylee Ann
   Dyer, Kathryn Ann
   Buckley, Jonathan David
   Brinkworth, Grant David
   Coates, Alison Mary
   Parfitt, Gaynor
   Howe, Peter Ranald Charles
   Noakes, Manny
   Dye, Louise
   Chadwick, Helen
   Murphy, Karen Joy
TI A randomised trial comparing low-fat diets differing in carbohydrate and
   protein ratio, combined with regular moderate intensity exercise, on
   glycaemic control, cardiometabolic risk factors, food cravings,
   cognitive function and psychological wellbeing in adults with type 2
   diabetes: Study protocol
SO CONTEMPORARY CLINICAL TRIALS
LA English
DT Article
DE Diabetes; Glycemic; Cardiometabolic; Cognitive; Psychological; Protocol
ID IMPAIRED GLUCOSE-TOLERANCE; QUALITY-OF-LIFE; EMOTIONAL DISTRESS; LOAD
   BREAKFAST; PROBLEM AREAS; WEIGHT-LOSS; MELLITUS; VALIDATION; HEALTH;
   QUESTIONNAIRE
AB Background: Hypocaloric low-fat diets, high in protein with moderate carbohydrate (HP) can enhance weight loss, improve glycaemic control and improve cardiometabolic health risk factors in type 2 diabetes mellitus (T2DM). However, it is unclear whether the metabolic benefits observed during weight loss are sustained during energy-balance and weight maintenance. Furthermore, there is a lack of evidence regarding the effect of HP diets on food cravings, cognitive function and psychological wellbeing in T2DM, despite carbohydrate food cravings, cognitive impairment and depression being associated with hyperglycaemia.
   Methods/design: Overweight/obese adults with T2DM were randomised to consume either a HP diet (n = 32, similar to 32% protein, 33% carbohydrate, 30% fat) or a higher-carbohydrate diet (HC, n = 29, similar to 22% protein, 51% carbohydrate, 22% fat) for 24 weeks with 30 min of moderate intensity exercise five days/week for the study duration. There were 2 phases: a 12 week weight loss phase followed by a 12 week weight maintenance phase. Primary outcome was glycaemic control (glycosylated haemoglobin; HbA1c). Secondary outcomes were cardiometabolic risk factors (body composition, fasting blood pressure, blood lipids, glucose, insulin and C-reactive protein), food cravings, cognitive function (memory; psychomotor and executive function and psychological well-being. Outcomes were measured at baseline and the end of each 12-week intervention phase. Data will be analysed as intention-to-treat using linear mixed effects models.
   Conclusion: This study will examine the effects of two dietary interventions on health outcomes in T2DM during weight loss and notably following weight maintenance where there is a paucity of evidence. (C) 2015 Published by Elsevier Inc.
C1 [Watson, Nerylee Ann; Dyer, Kathryn Ann; Buckley, Jonathan David; Coates, Alison Mary; Parfitt, Gaynor; Murphy, Karen Joy] Univ S Australia, Sansom Inst Hlth Res, Alliance Res Exercise Nutr & Act, Adelaide, SA 5001, Australia.
   [Brinkworth, Grant David; Noakes, Manny] Commonwealth Sci & Ind Res Org, Food & Nutr, Adelaide, SA 5000, Australia.
   [Howe, Peter Ranald Charles] Univ Newcastle, Sch Biomed Sci & Pharm, Clin Nutr Res Ctr, Callaghan, NSW 2308, Australia.
   [Dye, Louise; Chadwick, Helen] Univ Leeds, Sch Psychol, Leeds LS2 9JT, W Yorkshire, England.
C3 University of South Australia; Commonwealth Scientific & Industrial
   Research Organisation (CSIRO); University of Newcastle; University of
   Leeds
RP Murphy, KJ (corresponding author), Univ S Australia, Sansom Inst Hlth Res, Alliance Res Exercise Nutr & Act, GPO Box 2471, Adelaide, SA 5001, Australia.
EM nerylee.watson@mymail.unisa.edu.au; Kate.Dyer@unisa.edu.au;
   jon.Bucldey@unisa.edu.au; grant.brinkworth@csiro.au;
   Alison.Coates@unisa.edu.au; Gaynor.Parfitt@unisa.edu.au;
   Peter.Howe@newcastle.edu.au; manny.noalces@csiro.au; LDye@leeds.ac.uk;
   H.KChadwick@leeds.ac.uk; Karen.Murphy@unisa.edu.au
RI noakes, manny/H-2813-2013; Brinkworth, Grant/H-2815-2013; Chadwick,
   Helen/HSH-3884-2023; Buckley, Jonathan/B-7830-2009; Howe,
   Peter/A-5006-2008; Murphy, Karen/B-5163-2009; Parfitt,
   Gaynor/G-7640-2012; Coates, Alison/A-3988-2009
OI Chadwick, Helen/0000-0002-8022-5490; Parfitt,
   Gaynor/0000-0002-5547-5797; Murphy, Karen/0000-0002-2589-1319; Howe,
   Peter/0000-0001-6546-7742; Brinkworth, Grant/0000-0001-9017-8395;
   Buckley, Jonathan/0000-0003-0298-2186; Coates,
   Alison/0000-0003-1031-2545
FU Pork Co-operative Research Centre (Pork CRC), an Australian Government
   funding initiative
FX The authors thank the participants for taking part in this trial. Also
   thank you to Professor Graham Giles of the Cancer Epidemiology Centre of
   The Cancer Council Victoria, for permission to use the Dietary
   Questionnaire for Epidemiological Studies (Version 2), Melbourne: The
   Cancer Council Victoria, 1996. We gratefully acknowledge the following
   people for their assistance: Prof Adrian Esterman for assistance with
   statistical design, Sarah Biermann for assisting with volunteer
   screening and data entry, Dr. Simon Spedding for the medical management
   of trial recruitment, Paul Foster, Janna Lutze and Pennie Taylor for
   assisting in planning the diets and Julia Weaver and Louise Massie for
   trial assistance. Finally, we would like to acknowledge the following
   organisations for their generous donations of study foods including:
   Australian Health and Nutrition Association Ltd. (Sanitarium) for
   Weet-Bix (TM) breakfast cereal, Bega Cheese Limited for reduced-fat
   cheese and The Almond Board of Australia for almonds. This study was
   funded by a grant from the Pork Co-operative Research Centre (Pork CRC),
   an Australian Government funding initiative. No sponsor or funding
   source had a role in any aspect of the design or conduct of this study.
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NR 51
TC 12
Z9 12
U1 0
U2 54
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1551-7144
EI 1559-2030
J9 CONTEMP CLIN TRIALS
JI Contemp. Clin. Trials
PD NOV
PY 2015
VL 45
BP 217
EP 225
DI 10.1016/j.cct.2015.11.001
PN B
PG 9
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA DA4FJ
UT WOS:000367755200012
PM 26546883
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Rakel, RE
AF Rakel, Robert E.
TI Clinical and Societal Consequences of Obstructive Sleep Apnea and
   Excessive Daytime Sleepiness
SO POSTGRADUATE MEDICINE
LA English
DT Article
DE excessive daytime sleepiness; obstructive sleep apnea; primary care;
   quality of life; comorbidities
ID POSITIVE AIRWAY PRESSURE; QUALITY-OF-LIFE; GENERAL-POPULATION SAMPLE;
   BLOOD-PRESSURE; CARDIOVASCULAR-DISEASE; INSULIN-RESISTANCE; DEPRESSIVE
   SYMPTOMS; DRIVING SIMULATOR; MEDICAL THERAPY; RISK-FACTOR
AB Obstructive sleep apnea (OSA) is the most common sleep-related breathing disorder. Although frequently undiagnosed, OSA is highly prevalent and presents most often with excessive daytime sleepiness (EDS). While obesity is the major predisposing factor, patients with OSA and EDS are at increased risk of other conditions, including cardiovascular disease, type 2 diabetes, cognitive impairment. and depression. Significant consequences include morbidity and mortality from the associated conditions in addition to personal and societal consequences of cognitive impairment, such as driving and workplace accidents. Primary care physicians are ideally placed to screen for OSA and EDS in patients who present with commonly comorbid conditions such as obesity, cardiovascular disease, metabolic syndrome, and depression. Conversely, treatment of OSA and associated EDS might help alleviate significant comorbidities and their clinical and societal consequences.
C1 Baylor Coll Med, Dept Family & Community Med, Houston, TX 77098 USA.
C3 Baylor College of Medicine
RP Rakel, RE (corresponding author), Baylor Coll Med, Dept Family & Community Med, Mail Stop BCM700,3701 Kirby Dr,Suite 600, Houston, TX 77098 USA.
EM rrakel@bcm.edu
FU Anthemis Consulting Ltd.; Cephalon Inc., Frazer, PA
FX The author thanks Daniel I. Loube, MD, Providence Physician Division,
   Beaverton, OR, for useful discussions. Editorial support was provided by
   Anthemis Consulting Ltd. and was funded by Cephalon Inc., Frazer, PA.
   who provided a medical accuracy review. The author was not compensated
   and retained full editorial control over the content of the paper.
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NR 100
TC 59
Z9 68
U1 0
U2 11
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0032-5481
EI 1941-9260
J9 POSTGRAD MED
JI Postgrad. Med.
PD JAN
PY 2009
VL 121
IS 1
BP 86
EP 95
DI 10.3810/pgm.2009.01.1957
PG 10
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 399ML
UT WOS:000262803900008
PM 19179816
DA 2025-06-11
ER

PT J
AU Kasak, M
   Ceylan, MF
   Hesapcioglu, ST
   Senat, A
   Erel, Ö
AF Kasak, Meryem
   Ceylan, Mehmet Fatih
   Hesapcioglu, Selma Tural
   Senat, Almila
   Erel, Ozcan
TI Peroxisome Proliferator-Activated Receptor Gamma (PPARγ) Levels in
   Adolescent with Bipolar Disorder and Their Relationship with Metabolic
   Parameters
SO JOURNAL OF MOLECULAR NEUROSCIENCE
LA English
DT Article
DE Bipolar disorder; Etiology; Inflammation; Metabolic syndrome; PPAR
   gamma; Adolescence
ID MOOD DISORDERS; SCHIZOPHRENIA; PIOGLITAZONE; INFLAMMATION; RELIABILITY;
   PREVALENCE; DEPRESSION; CHILDREN; VALIDITY; EPISODE
AB Peroxisome proliferator-activated receptor gamma (PPAR gamma) is one of the immune and metabolic regulatory agents. This study examined the serum PPAR gamma levels and metabolic syndrome (MetS) parameters in pediatric bipolar disorder (PBD) adolescents and compared them with healthy subjects. Serum PPAR gamma levels, fasting blood glucose (FBG), high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), and fasting insulin levels of 39 PBD-type I (age range: 14-18) and 36 age- and sex-matched healthy control subjects were compared. The anthropometric measurements were also analyzed, including body weight, height, body mass index (BMI), waist circumference (WC), and blood pressure measurements. The PPAR gamma levels were significantly lower, and the MetS prevalence was significantly higher in the PBD group than in the control group. The mean BMI, WC, serum TG, and FBG values of the PBD group were statistically higher than the healthy control group. There was no significant relationship between the PPAR gamma levels and metabolic parameters except fasting glucose. Lower PPAR gamma activity and higher MetS prevalence in PBD indicate dysregulation of immune and metabolic regulatory parameters. These results may shed light on developing new PBD medications.
C1 [Kasak, Meryem] Ankara City Hosp, Dept Child & Adolescent Psychiat, Ankara, Turkey.
   [Ceylan, Mehmet Fatih; Hesapcioglu, Selma Tural] Ankara Yildirim Beyazit Univ, Fac Med, Dept Child & Adolescent Psychiat, Ankara, Turkey.
   [Senat, Almila] Taksim Training & Res Hosp, Dept Biochem, Istanbul, Turkey.
   [Erel, Ozcan] Ankara City Hosp, Dept Biochem, Ankara, Turkey.
C3 City Hospital Ankara; Ankara Yildirim Beyazit University; Istanbul
   Gaziosmanpasa Taksim Training & Research Hospital; City Hospital Ankara
RP Kasak, M (corresponding author), Ankara City Hosp, Dept Child & Adolescent Psychiat, Ankara, Turkey.
EM meryemkasak90@gmail.com
RI Şenat, Almila/ACJ-4022-2022; Kaşak, Meryem/HGF-0390-2022; EREL,
   Ozcan/U-1008-2019; Tural Hesapcioglu, Selma/V-9119-2017
OI kasak, meryem/0000-0003-0176-868X; SENAT, Almila/0000-0002-5806-562X;
   Tural Hesapcioglu, Selma/0000-0002-4816-0228
CR American Psychiatric Association, 2013, Diagnostic and statistical manual of mental disorders, V5th ed, DOI DOI 10.1176/APPI.BOOKS.9780890425596
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NR 51
TC 3
Z9 3
U1 0
U2 3
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0895-8696
EI 1559-1166
J9 J MOL NEUROSCI
JI J. Mol. Neurosci.
PD JUN
PY 2022
VL 72
IS 6
BP 1313
EP 1321
DI 10.1007/s12031-022-02000-2
EA MAR 2022
PG 9
WC Biochemistry & Molecular Biology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Neurosciences & Neurology
GA 1W5WY
UT WOS:000771845600001
PM 35318563
DA 2025-06-11
ER

PT J
AU Weiner, M
   Warren, L
   Fiedorowicz, JG
AF Weiner, Miriam
   Warren, Lois
   Fiedorowicz, Jess G.
TI Cardiovascular morbidity and mortality in bipolar disorder
SO ANNALS OF CLINICAL PSYCHIATRY
LA English
DT Article
DE bipolar disorder; cardiovascular disease; mortality; metabolic syndrome;
   obesity; hypertension
ID MANIC-DEPRESSIVE PATIENTS; CIVIL STATE HOSPITALS; METABOLIC SYNDROME;
   DIABETES-MELLITUS; RISK-FACTORS; WEIGHT-GAIN; ATYPICAL ANTIPSYCHOTICS;
   PSYCHIATRIC-PATIENTS; 1ST ADMISSIONS; SCHIZOAFFECTIVE DISORDER
AB BACKGROUND: There has been considerable interest in the elevated risk of cardiovascular disease associated with serious mental illness. Although the contemporary literature has paid much attention to major depression and schizophrenia, focus on the risk of cardiovascular mortality for patients with bipolar disorder has been more limited, despite some interest in the historical literature.
   METHODS: We reviewed the historical and contemporary literature related to cardiovascular morbidity and mortality in bipolar disorder.
   RESULTS: In studies that specifically assess cardiovascular mortality, bipolar disorder has been associated with a near doubling of risk when compared with general population estimates. This may be explained by the elevated burden of cardiovascular risk factors found in this population. These findings predate modern treatments for bipolar disorder, which may further influence cardiovascular risk.
   CONCLUSIONS: Given the substantial risk of cardiovascular disease, rigorous assessment of cardiovascular risk is warranted for patients with bipolar disorder. Modifiable risk factors should be treated when identified. Further research is warranted to study mechanisms by which this elevated risk for cardiovascular disease are mediated and to identify systems for effective delivery of integrated medical and psychiatric care for individuals with bipolar disorder.
C1 [Fiedorowicz, Jess G.] Univ Iowa, Coll Publ Hlth, Dept Epidemiol, Dept Psychiat,Carver Coll Med, Iowa City, IA 52242 USA.
C3 University of Iowa
RP Fiedorowicz, JG (corresponding author), Univ Iowa, Coll Publ Hlth, Dept Epidemiol, Dept Psychiat,Carver Coll Med, 200 Hawkins Dr,W278GH, Iowa City, IA 52242 USA.
EM jess-fiedorowicz@uiowa.edu
RI Fiedorowicz, Jess/I-2512-2019
OI Fiedorowicz, Jess/0000-0003-2057-4071
FU National Institute of Mental Health [1K23MH083695-01A210]; Nellie Ball
   Trust; NARSAD; Institute for Clinical and Translational Science at the
   University of Iowa [3 UL1 RR024979-03S4]; Eli Lilly and Company
FX Dr. Fiedorowicz is supported by the National Institute of Mental Health
   (1K23MH083695-01A210), the Nellie Ball Trust Research Fund, and a NARSAD
   Young Investigator Award, and the Institute for Clinical and
   Translational Science at the University of Iowa (3 UL1 RR024979-03S4).
   Dr. Fiedorowicz currently serves on colleagues' studies with
   Neurosearch, Vitalin/Enzymatic Therapy, and the National Center for
   Complementary and Alternative Medicine/Food and Drug Administration
   Orphan Products division. He also has received research support for
   participating in a colleague's investigator-initiated study with Eli
   Lilly and Company. Ms. Weiner and Ms. Warren report no financial
   relationship with any company whose products are mentioned in this
   article, or with manufacturers of competing products.
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NR 75
TC 177
Z9 189
U1 1
U2 18
PU QUADRANT HEALTHCOM INC
PI PARSIPPANY
PA 7 CENTURY DRIVE, STE 302, PARSIPPANY, NJ 07054-4603 USA
SN 1040-1237
EI 1547-3325
J9 ANN CLIN PSYCHIATRY
JI Ann. Clin. Psychiatry
PD FEB
PY 2011
VL 23
IS 1
BP 40
EP 47
PG 8
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 725AB
UT WOS:000287616500007
PM 21318195
DA 2025-06-11
ER

PT J
AU Grandner, MA
   Winkelman, JW
AF Grandner, Michael A.
   Winkelman, John W.
TI Nocturnal leg cramps: Prevalence and associations with demographics,
   sleep disturbance symptoms, medical conditions, and cardiometabolic risk
   factors
SO PLOS ONE
LA English
DT Article
ID MUSCLE CRAMPS
AB Background
   Nocturnal leg cramps (NLC) are common and poorly understood.
   Objective
   To determine the prevalence of NLC and associations with cardiometabolic, sleep, and behavioral risk factors in the US population.
   Design
   Cross-sectional epidemiology.
   Participants
   National Health and Nutrition Examination Survey, 2005-2006 and 2007-2008 waves.
   Main outcome(s) and measure(s)
   NLC were assessed with, "In the past month, how often did you have leg cramps while trying to sleep?" Responses were categorized as None, Mild, or Moderate-Severe. Demographics, medical history, sleep disturbances, and cardiometabolic risk factors were evaluated using the 2005-2006 dataset. Variables that demonstrated significant relationships to NLC after adjusting for age, sex, education, and BMI were assessed in the 2007-2008 dataset. Variables that were still significant were entered into a forward stepwise regression model combining both waves, to determine which variables best explained the variance in NLC.
   Results
   Prevalence was 24-25% reporting mild and 6% reporting moderate-severe NLC. NLC increased with age, lower education, unemployment, shorter sleep duration, all assessed sleep symptoms (nocturnal "leg jerks", snoring, snorting/gasping, difficulty falling asleep, difficulty maintaining sleep, non-restorative sleep, sleepiness, use of sleep medications), higher BMI, smoking, medical history (hypertension, heart failure, angina, stroke, arthritis, respiratory disease, and cancer), depression symptoms, and biomarkers (CRP, HbA1c, calcium, cadmium, red blood cells). Stepwise analysis showed that moderate-severe nocturnal leg cramps were associated with (in decreasing order of partial R-2): leg jerks, poor overall health, arthritis, difficulty falling asleep, age, nonrestorative sleep, red blood cell count, lower education, angina, and difficulty maintaining sleep.
   Conclusions and relevance
   Based on this first large, representative study, NLC occurring >5x per month are reported by 6% of the adult US population. Sleep disturbance symptoms and health conditions are associated with higher frequency of NLC, suggesting that NLC is a marker, and possibly contributor, to poor sleep and general health.
C1 [Grandner, Michael A.] Univ Arizona, Dept Psychiat, Tucson, AZ USA.
   [Winkelman, John W.] Harvard Med Sch, Massachusetts Gen Hosp, Dept Psychiat, Boston, MA 02115 USA.
   [Winkelman, John W.] Harvard Med Sch, Massachusetts Gen Hosp, Dept Neurol, Boston, MA 02115 USA.
C3 University of Arizona; Harvard University; Harvard Medical School;
   Harvard University Medical Affiliates; Massachusetts General Hospital;
   Harvard University; Harvard University Medical Affiliates; Massachusetts
   General Hospital; Harvard Medical School
RP Winkelman, JW (corresponding author), Harvard Med Sch, Massachusetts Gen Hosp, Dept Psychiat, Boston, MA 02115 USA.; Winkelman, JW (corresponding author), Harvard Med Sch, Massachusetts Gen Hosp, Dept Neurol, Boston, MA 02115 USA.
EM jwwinkelman@partners.org
OI Grandner, Michael/0000-0002-4626-754X
FU National Heart, Lung, and Blood Institute [K23HL110216]; Luitpold
   Pharmaceuticals; Xenoport; UCB Pharma; NeuroMetrix; NIMH
FX This work received support from the National Heart, Lung, and Blood
   Institute, Grant number: K23HL110216, URL: https://www.nhlbi.nih.gov/.
   Author who received funding: MG. The funder had no role in study design,
   data collection and analysis, decision to publish, or preparation of the
   manuscript.The authors wish to thank Dr. Susan Redline for her
   contributions to editing the manuscript, as well as Nicholas Jackson for
   input on statistical models. Dr. Winkelman is a consultant for Merck and
   Flex Pharma, has provided expert testimony for Cantor Colburn, receives
   royalties from UpToDate, and has received research grants from Luitpold
   Pharmaceuticals, Xenoport, UCB Pharma, NeuroMetrix, and NIMH. Dr.
   Grandner is a consultant for FitBit and is on the Scientific Advisory
   Board for CurAegis Technologies. He has provided expert testimony for
   Morrison Foerster. This abstract was presented at the 2016 APSS SLEEP
   meeting.
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NR 19
TC 21
Z9 25
U1 0
U2 6
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JUN 6
PY 2017
VL 12
IS 6
AR e0178465
DI 10.1371/journal.pone.0178465
PG 15
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA EW9YQ
UT WOS:000402875700013
PM 28586374
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Peng, L
   Di, XP
   He, SX
   Zeng, X
   Shen, H
   Zhu, HL
   Luo, DY
AF Peng, Liao
   Di, Xing-peng
   He, Shi-xin
   Zeng, Xiao
   Shen, Hong
   Zhu, Hui-li
   Luo, De-yi
TI Metabolic syndrome in women with and without interstitial
   cystitis/bladder pain syndrome
SO INTERNATIONAL UROGYNECOLOGY JOURNAL
LA English
DT Article
DE Metabolic syndrome; Obesity; Body mass index; Interstitial cystitis;
   bladder pain syndrome
ID URINARY-TRACT SYMPTOMS; SYNDROME/INTERSTITIAL CYSTITIS;
   DIABETES-MELLITUS; BLADDER PAIN; INCONTINENCE; RISK; CHOLESTEROL;
   PREVALENCE; INSULIN; IMPACT
AB Introduction and hypothesis The aim of this study was to compare the frequency of metabolic syndrome (MetS) in patients with and without interstitial cystitis/bladder pain syndrome (IC/BPS). Methods This case-control study evaluated the indicators of MetS in 287 females with IC/BPS and in 287 females without IC/BPS in West China Hospital between January 2010 and January 2020. Then, the number of voids per day, frequency of night urination, O'Leary-Sant Interstitial Cystitis Symptom/Problem Index, and visual analog scale were examined in the two groups. Results Based on both the National Cholesterol Education Program Adult Treatment Panel III recommendations and the International Diabetes Federation criteria, the distribution of MetS was statistically higher in patients with IC/BPS than in the control group, with 34.8% vs 17.8% (P < 0.0001) and 34.2% vs 20.9% (P = 0.0005), respectively. Regarding symptom scores, the IC/BPS group demonstrated significantly higher scores than the control group in all aspects (P < 0.0001). More patients with anxiety (P < 0.0001), insomnia (P < 0.0001), hypertension (P = 0.0001), and diabetes mellitus (P = 0.017) were observed in the IC/BPS group. Moreover, the findings indicated that patients with IC/BPS had a higher BMI (P = 0.0001) and larger waist circumference (P = 0.0001). Blood tests presented a significantly higher level of fasting glycemia, serum cystatin-C, and triglycerides in patients with IC/BPS. Furthermore, higher ORs for the occurrence of MetS among cases were observed, although this was not statistically significant. Conclusions MetS frequency was relatively high in patients with IC/BPS. Further research is needed to understand the common pathophysiologic mechanism of IC/BPS and MetS.
C1 [Peng, Liao; Di, Xing-peng; Zeng, Xiao; Shen, Hong; Luo, De-yi] Sichuan Univ, West China Hosp, Inst Urol, Dept Urol, 37 Guo Xue Xiang, Chengdu 610041, Sichuan, Peoples R China.
   [He, Shi-xin] Chengdu Med Coll, Affiliated Hosp 1, Dept Dermatol, Xindu, Sichuan, Peoples R China.
   [Zhu, Hui-li] Sichuan Univ, West China Univ Hosp 2, Dept Obstet & Gynecol, 20,Sect 3,Renmin Nan Lu, Chengdu 610041, Sichuan, Peoples R China.
C3 Sichuan University; Chengdu Medical College; Sichuan University
RP Luo, DY (corresponding author), Sichuan Univ, West China Hosp, Inst Urol, Dept Urol, 37 Guo Xue Xiang, Chengdu 610041, Sichuan, Peoples R China.; Zhu, HL (corresponding author), Sichuan Univ, West China Univ Hosp 2, Dept Obstet & Gynecol, 20,Sect 3,Renmin Nan Lu, Chengdu 610041, Sichuan, Peoples R China.
EM 13551287548@163.com; luodeyi1985@163.com
RI Zeng, Xiao/ABG-5938-2021; Di, Xingpeng/HKN-5814-2023
OI Di, Xingpeng/0000-0002-1921-5509
FU National Natural Science Fund of China [81770673]; 1.3.5 Project for
   Disciplines of Excellence, West China Hospital, Sichuan University
   [ZY2017310]; Project of Science and Technology Department of Sichuan
   Province [2018SZ0177, 2018SZ0055]; Foundation of Science and Technology
   Department of Sichuan Province [2019YFS0281]
FX This study was funded by the National Natural Science Fund of China
   (grant no. 81770673), 1.3.5 Project for Disciplines of Excellence, West
   China Hospital, Sichuan University (grant no. ZY2017310), Project of
   Science and Technology Department of Sichuan Province (2018SZ0177,
   2018SZ0055), and Foundation of Science and Technology Department of
   Sichuan Province (2019YFS0281).
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NR 36
TC 6
Z9 6
U1 0
U2 4
PU SPRINGER LONDON LTD
PI LONDON
PA 236 GRAYS INN RD, 6TH FLOOR, LONDON WC1X 8HL, ENGLAND
SN 0937-3462
EI 1433-3023
J9 INT UROGYNECOL J
JI Int. Urogynecol. J.
PD MAY
PY 2021
VL 32
IS 5
BP 1299
EP 1306
DI 10.1007/s00192-020-04605-w
EA NOV 2020
PG 8
WC Obstetrics & Gynecology; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology; Urology & Nephrology
GA SF9XU
UT WOS:000590948100001
PM 33215272
DA 2025-06-11
ER

PT J
AU Susic, D
   Varagic, J
AF Susic, Dinko
   Varagic, Jasmina
TI Obesity A Perspective from Hypertension
SO MEDICAL CLINICS OF NORTH AMERICA
LA English
DT Article
DE Obesity; Hypertension; Sodium; Sympathetic nervous system;
   Renin-angiotensin-aldosterone system; Insulin resistance; Adipokines
ID BODY-MASS-INDEX; SYMPATHETIC-NERVOUS-SYSTEM; CARDIOMETABOLIC
   RISK-FACTORS; SELECTIVE LEPTIN RESISTANCE; TYPE-2 DIABETES-MELLITUS;
   INTIMA-MEDIA THICKNESS; BLOOD-PRESSURE CONTROL; CHRONIC KIDNEY-DISEASE;
   ADIPOSE-TISSUE MASS; WEIGHT-LOSS
AB The prevalence of obesity-related hypertension is high worldwide and has become a major health issue. The mechanisms by which obesity relates to hypertensive disease are still under intense research scrutiny, and include altered hemodynamics, impaired sodium homeostasis, renal dysfunction, autonomic nervous system imbalance, endocrine alterations, oxidative stress and inflammation, and vascular injury. Most of these contributing factors interact with each other at multiple levels. Thus, as a multifactorial and complex disease, obesity-related hypertension should be recognized as a distinctive form of hypertension, and specific considerations should apply in planning therapeutic approaches to treat obese individuals with high blood pressure.
C1 [Susic, Dinko] Ochsner Clin Fdn, Hypertens Res Lab, 1514 Jefferson Highway, New Orleans, LA 70121 USA.
   [Varagic, Jasmina] Wake Forest Sch Med, Hypertens & Vasc Res, Dept Surg, Med Ctr Blvd, Winston Salem, NC 27157 USA.
   [Varagic, Jasmina] Wake Forest Sch Med, Dept Physiol & Pharmacol, Med Ctr Blvd, Winston Salem, NC 27157 USA.
C3 Ochsner Health System; Wake Forest University; Wake Forest University
RP Varagic, J (corresponding author), Wake Forest Sch Med, Hypertens & Vasc Res, Dept Surg, Med Ctr Blvd, Winston Salem, NC 27157 USA.
EM jvaragic@wakehealth.edu
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NR 186
TC 35
Z9 42
U1 0
U2 8
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0025-7125
EI 1557-9859
J9 MED CLIN N AM
JI Med. Clin. N. Am.
PD JAN
PY 2017
VL 101
IS 1
BP 139
EP +
DI 10.1016/j.mcna.2016.08.008
PG 20
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA EG3UQ
UT WOS:000390970600014
PM 27884225
DA 2025-06-11
ER

PT J
AU Benson, J
   DeVries, M
   McLaurin-Jiang, S
   Garner, CD
AF Benson, Jessie
   DeVries, Matthew
   McLaurin-Jiang, Skye
   Garner, Christine D.
TI Experiences accessing nutritious foods and perceptions of nutritional
   support needs among pregnant and post-partum mothers with low income in
   the United States
SO MATERNAL AND CHILD NUTRITION
LA English
DT Article
DE food assistance; maternal nutrition; meal programme; post-partum period;
   pregnancy; qualitative; social determinants
ID WEIGHT RETENTION; INSECURITY; KNOWLEDGE
AB Access to nutritious foods, a social determinant of health, contributes to disparities in maternal and infant health outcomes such as mental health, breastfeeding intensity and cardiometabolic risk. This study explored perceived nutrition access and intake among pregnant or post-partum women eligible for Medicaid. Qualitative, semistructured interviews were conducted with 18 women who were either currently pregnant (n = 4) or up to 12 months post-partum (n = 14) in 2021-2022. Mothers spoke English (n = 11) or Spanish (n = 7) and lived in the Texas Panhandle. Interviews were audio-recorded, transcribed, translated (Spanish to English) and verified. Two or more researchers coded each interview until consensus was reached using thematic analysis with ATLAS.ti software. The study revealed five drivers for nutrition access. (1) Social factors influenced nutrition; those with less support expressed limited ability to eat healthfully. (2) The Women, Infants and Children program was perceived as a helpful resource for some, while others faced challenges obtaining it. (3) Stress was bidirectionally related to unhealthy food choices, with food sometimes used as a coping mechanism. (4) Mothers prioritized their babies and others and had limited ability and time to prepare healthy meals. (5) Most participants felt they received inadequate nutrition guidance from their healthcare providers. Participants provided positive responses to a proposed nutritious home-delivered meal intervention. Low-income women may experience nutritional challenges specific to this life stage. Interventions that reduce stress and burden of household tasks (e.g. cooking) and improve education and access to nutritious foods may improve mothers' ability to consume nutritious foods.
   Social support, stress, prioritization of others and lack of professional guidance influenced access to and consumption of nutritious foods during and after pregnancy. image
   Pregnant and post-partum women desire to eat nutritious foods for their own health and that of their infants. More support is needed for women in the post-partum period as prioritization of others and the stressful transition of caring for a newborn hinder women from maintaining healthy eating habits. Pregnant and post-partum women want focused nutritional guidance from their healthcare providers. A home-delivered, nutritious meal programme may be an acceptable intervention to help alleviate the nutritional barriers that are faced by pregnant and post-partum women.
C1 [Benson, Jessie; DeVries, Matthew] Texas Tech Univ Hlth Sci Ctr, Sch Med, Amarillo, TX 79106 USA.
   [DeVries, Matthew] Phoenix Childrens Hosp, Phoenix, AZ USA.
   [McLaurin-Jiang, Skye] Texas Tech Univ Hlth Sci Ctr, Dept Pediat, Amarillo, TX USA.
   [Garner, Christine D.] Texas Tech Univ Hlth Sci Ctr, InfantRisk Ctr, Amarillo, TX USA.
   [Garner, Christine D.] Texas Tech Univ Hlth Sci Ctr, Dept Obstet & Gynecol, Amarillo, TX USA.
C3 Texas Tech University System; Texas Tech University Health Sciences
   Center Amarillo; Texas Tech University Health Sciences Center Lubbock;
   Phoenix Children's Hospital; Texas Tech University System; Texas Tech
   University Health Sciences Center Amarillo; Texas Tech University Health
   Sciences Center Lubbock; Texas Tech University System; Texas Tech
   University Health Sciences Center Amarillo; Texas Tech University Health
   Sciences Center Lubbock; Texas Tech University System; Texas Tech
   University Health Sciences Center Amarillo; Texas Tech University Health
   Sciences Center Lubbock
RP Benson, J (corresponding author), Texas Tech Univ Hlth Sci Ctr, Sch Med, Amarillo, TX 79106 USA.
EM jessiebenson720@gmail.com
OI Benson, Jessie/0000-0002-5103-3959; McLaurin-Jiang,
   Skyler/0000-0001-7160-5128
FU Laura W. Bush Institute for Women's Health
FX The authors thank Ashley Allcorn, MA, LCSW, and Ilean McCarthy, LCSW,
   for assistance with the development of the interview guide and conduct
   of the interviews and focus groups; Teresa Baker, MD, and Maury Roman,
   MBA for assistance with participant recruitment; and Brenda Garcia, MS,
   RD, manager of health and wellness for United Supermarkets stores, for
   assistance with design and selection of prepared nutritious meals. This
   study was supported by funding from the Laura W. Bush Institute for
   Women's Health.
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NR 44
TC 2
Z9 2
U1 2
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1740-8695
EI 1740-8709
J9 MATERN CHILD NUTR
JI Matern. Child Nutr.
PD OCT
PY 2024
VL 20
IS 4
DI 10.1111/mcn.13660
EA MAY 2024
PG 11
WC Nutrition & Dietetics; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics; Pediatrics
GA M7F3B
UT WOS:001234293200001
PM 38812121
OA Green Published
DA 2025-06-11
ER

PT J
AU Sieminska, L
   Sieminska, K
   Ditffeld, A
   Kotecka-Blicharz, A
AF Sieminska, Lucyna
   Sieminska, Katarzyna
   Ditffeld, Anna
   Kotecka-Blicharz, Agnieszka
TI Fibroblast growth factor 21 in patients with mild autonomic cortisol
   secretion and non-functioning adrenal incidentalomas
SO ENDOKRYNOLOGIA POLSKA
LA English
DT Article
DE FGF21; adrenal incidentaloma; mild autonomic cortisol secretion; adrenal
   adenoma size; cardiometabolic index; lipid accumulation product; obesity
ID METABOLIC SYNDROME; CELL-PROLIFERATION; INSULIN-RESISTANCE; FGF21;
   EXPRESSION; GLUCOSE; OBESITY; LIVER
AB Introduction: Epidemiological studies have reported a link between adrenocortical adenomas (ACA), obesity, and cardiometabolic risk. Fibroblast growth factor 21 (FGF21) is a stress-induced protein synthesised predominantly in the liver, which regulates metabolism. The aim of the current study was to evaluate the concentration of FGF21 in patients with ACA and its relationship with hypothalamic-pituitary-adrenal function, obesity, markers of cardiometabolic health, and adenoma size. Material and methods: A total of 197 patients with ACA were included in the analysis, 82 diagnosed with mild autonomous cortisol secretion (MACS) and 115 with non-functioning adrenal adenoma incidentaloma (NFAI). MACS was defined as serum cortisol concentration post 1 mg dexamethasone test (DST) >= 1.8 mu g/dL. In each patient weight, height, and waist circumference were measured, and body mass index (BMI) was calculated. Serum concentrations of FGF21, cortisol, dehydroepiandrosterone sulphate, adrenocorticotropic hormone (ACTH), total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglycerides, glucose, and insulin were measured. The cortisol-to-ACTH ratio, homeostatic model assessment for insulin resistance index (HOMA-IR), lipid accumulation product (LAP), and cardiometabolic index (CMI) were calculated. Adrenal tumour size was evaluated from imaging procedures. Results: Serum FGF21 concentrations were significantly higher in patients with MACS than in NFAI, which was independent of BMI. There were no differences between MACS and NFAI groups regarding HOMA-IR, LAP, and CMI. We observed a positive correlation between serum FGF21 concentration and cortisol level after DST, as well as the cortisol-to-ACTH ratio. FGF21 was negatively correlated with dehydroepiandrosterone sulphate (DHEAS). There were no significant correlations between serum FGF21 concentration and BMI, waist circumference, and HOMA-IR, but serum FGF21 levels were positively correlated with TG, LAP, and CMI. Positive relationships between adenoma size and serum FGF21 concentration were found. Conclusions: Higher levels of FGF21 in adrenal tumours with MACS when compared with NFAI represent another pathophysiological link related to chronic glucocorticoid excess. (Endokrynol Pol 2024; 75 (6): 672-683)
C1 [Sieminska, Lucyna] Med Univ Silesia, Fac Med Sci Zabrze, Dept Pathophysiol & Endocrinol, Pathophysiol Div, Katowice, Poland.
   [Sieminska, Katarzyna] Med Univ Silesia, Dept Pathophysiol & Endocrinol, Pathophysiol Div, Sci Students Assoc,Fac Med Sci Zabrze, Katowice, Poland.
   [Ditffeld, Anna] Cty Hosp, Endocrinol Ambulatory, Piekary Slaskie, Poland.
   [Kotecka-Blicharz, Agnieszka] Maria Sklodowska Curie Natl Res Inst Oncology, Dept Nucl Med & Endocrine Oncol, Gliwice, Silesia, Poland.
C3 Medical University of Silesia; Medical University of Silesia
RP Sieminska, L (corresponding author), Med Univ Silesia, Fac Med Sci Zabrze, Dept Pathophysiol & Endocrinol, Pathophysiol Div, Katowice, Poland.
EM LSieminska@sum.edu.pl
OI Kotecka-Blicharz, Agnieszka/0000-0002-8086-7346
FU Medical University of Silesia [PCN-1-140-N-0/K, PCN-1-081/K/1/K]
FX Funding This work was funded by the Medical University of Silesia, grant
   Nos. PCN-1-140-N-0/K and PCN-1-081/K/1/K
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NR 67
TC 0
Z9 0
U1 0
U2 0
PU VIA MEDICA
PI GDANSK
PA UL SWIETOKRZYSKA 73, 80-180 GDANSK, POLAND
SN 0423-104X
J9 ENDOKRYNOL POL
JI Endokrynol. Pol.
PY 2024
VL 75
IS 6
BP 672
EP 683
DI 10.5603/ep.102598
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA Q7N9Z
UT WOS:001386511500001
PM 40091329
OA gold
DA 2025-06-11
ER

PT J
AU Dixon, JB
   Hayden, MJ
   Lambert, GW
   Dawood, T
   Anderson, ML
   Dixon, ME
   O'Brien, PE
AF Dixon, John B.
   Hayden, Melissa J.
   Lambert, Gavin W.
   Dawood, Tye
   Anderson, Margaret L.
   Dixon, Maureen E.
   O'Brien, Paul E.
TI Raised CRP levels in obese patients: Symptoms of depression have an
   independent positive association
SO OBESITY
LA English
DT Article
ID C-REACTIVE PROTEIN; ACUTE MYOCARDIAL-INFARCTION; PSYCHOSOCIAL
   RISK-FACTORS; WEIGHT-LOSS; SYSTEMIC INFLAMMATION; CARDIOVASCULAR RISK;
   MAJOR DEPRESSION; HEART-DISEASE; MARKERS; INTERLEUKIN-6
AB Background: Depression and obesity, the two common ailments of modern society, are associated with increased risk of coronary artery disease and raised C-reactive protein (CRP) levels. Are the effects of depression and obesity related or do they influence CRP levels independently?
   Objective: In 493 consecutive patients presenting for obesity surgery, we explored the relationship between symptoms of depression and raised CRP levels after controlling for confounding factors.
   Methods and Procedures: Depression was measured using the Beck Depression Inventory (BDI). Confounding variables were age, gender, BMI, waist and hip measures, smoking and alcohol habits, medications, biochemical measures of the metabolic syndrome, and indirect measures of insulin resistance. General linear regression sought variables independently associated with CRP levels.
   Results: These patients had a BMI range from 31 to 91 kg/m(2), participants age ranged from 14 to 71 years, and 76% were women. The median CRP concentration was 7.7 mg/l (interquartile range: 3.9-14), 40% had an abnormally raised concentration (>10 mg/l). The mean BDI score was 17.0 +/- 9.0, indicating symptoms of moderate depression. We found five independent factors associated with raised CRP levels. In order of strength of association, these were: higher BMI (beta = 0.36, P < 0.001), female gender (beta = -0.19, P < 0.001), estrogen therapy (beta = 0.18, P < 0.001), higher BDI score (beta = 0.11, P = 0.01), and insulin resistance index (beta = 0.11, P = 0.01), and with a combined R-2 = 0.24, (P < 0.001).
   Discussion: In obese patients, symptoms of depression were associated with raised CRP levels after controlling for confounding variables. Obese women on estrogen therapy are at risk of high CRP levels.
C1 [Dixon, John B.; Hayden, Melissa J.; Anderson, Margaret L.; Dixon, Maureen E.; O'Brien, Paul E.] Monash Univ, Alfred Hosp, Ctr Obes Res & Educ, Melbourne, Vic 3181, Australia.
   [Dixon, John B.; Lambert, Gavin W.; Dawood, Tye] Alfred Hosp, Baker Heart Res Inst, Melbourne, Vic, Australia.
C3 Monash University; Florey Institute of Neuroscience & Mental Health;
   Howard Florey Institute Affiliates; Florey Institute of Neuroscience &
   Mental Health; Howard Florey Institute Affiliates; Baker Heart and
   Diabetes Institute
RP Dixon, JB (corresponding author), Monash Univ, Alfred Hosp, Ctr Obes Res & Educ, Melbourne, Vic 3181, Australia.
EM john.dixon@med.monash.edu.au
RI Dixon, John/A-5318-2011; Lambert, Gavin/E-7384-2010; Dawood,
   Tye/A-8826-2011
OI Hayden, Melissa/0000-0002-4837-5894; Dixon, John/0000-0001-6399-7010;
   Lambert, Gavin/0000-0003-0315-645X
CR Alesci S, 2005, J CLIN ENDOCR METAB, V90, P2522, DOI 10.1210/jc.2004-1667
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NR 31
TC 34
Z9 40
U1 0
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1930-7381
EI 1930-739X
J9 OBESITY
JI Obesity
PD SEP
PY 2008
VL 16
IS 9
BP 2010
EP 2015
DI 10.1038/oby.2008.271
PG 6
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 345KP
UT WOS:000258996000005
PM 18497736
OA Bronze
DA 2025-06-11
ER

PT J
AU Karimzadeh, L
   Behrouz, V
   Sohrab, G
   Razavion, T
   Haji-Maghsoudi, S
AF Karimzadeh, Laleh
   Behrouz, Vahideh
   Sohrab, Golbon
   Razavion, Taraneh
   Haji-Maghsoudi, Saiedeh
TI The association between dietary nitrate, nitrite and total antioxidant
   capacity with cardiometabolic risk factors: a cross-sectional study
   among patients with type 2 diabetes
SO INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION
LA English
DT Article
DE Nitrate; nitrite; DTAC; diabetes; glycemic indices; lipid profile
ID BLOOD-PRESSURE; INORGANIC NITRATE; CARDIOVASCULAR HEALTH; ENDOTHELIAL
   FUNCTION; INSULIN-RESISTANCE; METABOLIC SYNDROME; GLUCOSE-TOLERANCE;
   OXIDATIVE STRESS; SODIUM-NITRITE; LIPID PROFILE
AB Diabetes is a common, chronic, and complex disorder that leads to several disabilities and serious complications. Certain nutrients can be effective in the management of diabetes mellitus. In the present study, we aimed to investigate the effects of dietary nitrate, nitrite, dietary total antioxidant capacity (DTAC), and nitric oxide (NO) index on some cardiometabolic parameters in patients with diabetes. This cross-sectional study was conducted on 100 participants with type 2 diabetes. A validated, semi-quantitative, food frequency questionnaire was collected to evaluate dietary intakes. Anthropometric parameters, blood pressure, and biochemical parameters, including glycemic indices, lipid profile, high-sensitive C-reactive protein (hs-CRP), and serum NO were measured using standard methods. Higher intakes of nitrate and nitrite in our study were primarily attributed to drinking water, vegetables, grains (for nitrate), dairy products, and legumes (for nitrite) rather than higher meat intakes. After adjustment for total energy, MET, BMI, and age, higher intake of nitrate was related to lower HbA1C (p = 0.001) and hs-CRP (p = 0.0.23), and greater HDL-C (p < 0.001) and serum NO (p = 0.008). Moreover, a greater nitrite intake was associated with lower DBP (p = 0.017), HbA1C (p = 0.040), FPG (p = 0.011), and higher serum NO values (p = 0.001). Higher amounts of DTAC and NO index were also related to greater DBP (p < 0.001, and p = 0.004, respectively) and lower hs-CRP (p = 0.004, and p = 0.009, respectively). High intakes of dietary nitrate and nitrite, in the context of high DTAC, are significantly associated with the improvement of some cardiometabolic parameters in patients with diabetes. HIGHLIGHTS center dot A higher intake of nitrite is related to improving glycemic indices. center dot A higher intake of nitrate is related to increasing HDL-C and decreasing hs-CRP. center dot A higher intake of nitrate and nitrite, with a high DTAC index, is related to reduced cardiometabolic parameters.
C1 [Karimzadeh, Laleh; Sohrab, Golbon] Shahid Beheshti Univ Med Sci, Natl Nutr & Food Technol Res Inst, Fac Nutr & Food Technol, Dept Clin Nutr & Dietet, Tehran, Iran.
   [Behrouz, Vahideh] Kerman Univ Med Sci, Fac Publ Hlth, Dept Nutr, Kerman, Iran.
   [Razavion, Taraneh] Univ Tehran Med Sci, Dept Med Parasitol & Mycol Publ Hlth, Tehran, Iran.
   [Haji-Maghsoudi, Saiedeh] Kerman Univ Med Sci, Inst Futures Studies Hlth, Modeling Hlth Res Ctr, Kerman, Iran.
C3 Shahid Beheshti University Medical Sciences; Kerman University of
   Medical Sciences; Tehran University of Medical Sciences; Kerman
   University of Medical Sciences
RP Behrouz, V (corresponding author), Kerman Univ Med Sci, Fac Publ Hlth, Dept Nutr, Kerman, Iran.; Sohrab, G (corresponding author), Natl Nutr & Food Technol Res Inst, Fac Nutr Sci & Food Technol, Dept Clin Nutr & Dietet, Tehran, Iran.
EM golbonsohrab@yahoo.com
RI behrouz, vahideh/AAL-5105-2020; Sohrab, Golbon/AHE-4922-2022
FU Shahid Beheshti University of Medical Sciences [1401-0.23]
FX This study is supported by Shahid Beheshti University of Medical
   Sciences (grant number: 1401-0.23).
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NR 65
TC 1
Z9 1
U1 1
U2 2
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0963-7486
EI 1465-3478
J9 INT J FOOD SCI NUTR
JI Int. J. Food Sci. Nutr.
PD OCT 2
PY 2024
VL 75
IS 7
BP 695
EP 706
DI 10.1080/09637486.2024.2395817
EA AUG 2024
PG 12
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA I4N3R
UT WOS:001300545000001
PM 39192837
DA 2025-06-11
ER

PT J
AU Mangge, H
   Zelzer, S
   Puerstner, P
   Schnedl, WJ
   Reeves, G
   Postolache, TT
   Weghuber, D
AF Mangge, Harald
   Zelzer, Sieglinde
   Puerstner, Peter
   Schnedl, Wolfgang J.
   Reeves, Gloria
   Postolache, Teodor T.
   Weghuber, Daniel
TI Uric Acid Best Predicts Metabolically Unhealthy Obesity With Increased
   Cardiovascular Risk in Youth and Adults
SO OBESITY
LA English
DT Article
ID SUBCUTANEOUS ADIPOSE-TISSUE; MUSCLE-CELL-PROLIFERATION; CARDIOMETABOLIC
   RISK; OXIDATIVE STRESS; ATHEROSCLEROSIS; CIRCUMFERENCE; DEFINITION;
   THICKNESS; DISEASE; BODY
AB Objective: The obesity prevalence is growing worldwide and largely responsible for cardiovascular disease, the most common cause of death in the western world. The rationale of this study was to distinguish metabolically healthy from unhealthy overweight/obese young and adult patients as compared to healthy normal weight age matched controls by an extensive anthropometric, laboratory, and sonographic vascular assessment.
   Design and Methods: Three hundred fifty five young [8 to <= 18 years, 299 overweight/obese(ow/ob), 56 normal weight (nw)] and 354 adult [>18-60 years, 175 (ow/ob), 179 nw)] participants of the STYJOBS/EDECTA (STYrian Juvenile Obesity Study/Early DEteCTion of Atherosclerosis) cohort were analyzed. STYJOBS/EDECTA (NCT00482924) is a crossectional study to investigate metabolic/cardiovascular risk profiles in normal and ow/ob people free of disease except metabolic syndrome (MetS).
   Results: From 299 young ow/ob subjects (8-<= 18 years), 108 (36%), and from 175 adult ow/ob subjects (>18-60 years), 79 (45%) had positive criteria for MetS. In both age groups, prevalence of MetS was greater among males. Overweight/obese subjects were divided into "healthy" (no MetS criterion except anthropometry fulfilled) and "unhealthy" (MetS positive). Although percentage body fat did not differ between "healthy" and "unhealthy" ow/ob, nuchal and visceral fat were significantly greater in the "unhealthy" group which had also significantly higher values of carotid intima media thickness (IMT). With MetS as the dependent variable, two logistic regressions including juveniles <= 18 years or adults >18 years were performed. The potential predictor variables selected with the exception of age and gender by t test comparisons included IMT, ultrasensitive c-reactive protein (US-CRP), IL-6, malondialdehyde (MDA), oxidized LDL, leptin, adiponectin, uric acid (UA), aldosterone, cortisol, transaminases, fibrinogen. In both groups, uric acid and in adults only, leptin and adiponectin, turned out as the best predictor.
   Conclusion: Serum levels of UA are a significant predictor of unhealthy obesity in juveniles and adults.
C1 [Mangge, Harald; Zelzer, Sieglinde] Med Univ Graz, Clin Inst Med & Chem Lab Diagnost, Graz, Austria.
   [Puerstner, Peter] Med Univ Graz, Dept Obstet & Gynecol, Endocrine Lab, Graz, Austria.
   [Reeves, Gloria] Univ Maryland, Sch Med, Dept Psychiat, Child & Adolescent Psychiat Div, Baltimore, MD 21201 USA.
   [Postolache, Teodor T.] Univ Maryland, Sch Med, Dept Psychiat, Mood & Anxiety Program, Baltimore, MD 21201 USA.
   [Weghuber, Daniel] Paracelsus Med Sch Salzburg, Dept Pediat, Salzburg, Austria.
C3 Medical University of Graz; Medical University of Graz; University
   System of Maryland; University of Maryland Baltimore; University System
   of Maryland; University of Maryland Baltimore; Paracelsus Private
   Medical University
RP Mangge, H (corresponding author), Med Univ Graz, Clin Inst Med & Chem Lab Diagnost, Graz, Austria.
EM harald.mangge@klinikum-graz.at
RI Weghuber, Daniel/AAN-1422-2020
OI Weghuber, Daniel/0000-0002-4389-0379; Schnedl,
   Wolfgang/0000-0002-5212-5230; Mangge, Harald/0000-0003-4067-247X;
   Postolache, Teodor/0000-0001-6056-4244
FU "Zukunftsfond Steiermark" Project "STYJOBS-Extension''; Austrian
   Nano-Initiative as part of the Nano-Health project [0200]; Austrian FWF
   (Fonds zur Forderung der Wissenschaftlichen Forschung) [N212-NAN];
   STYJOBS EDECTA Cohort
FX This work was funded by the "Zukunftsfond Steiermark" Project
   "STYJOBS-Extension''. Furthermore, the Austrian Nano-Initiative
   co-financed this work as part of the Nano-Health project (no. 0200), the
   sub-project NANO-PLAQUE being financed by the Austrian FWF (Fonds zur
   Forderung der Wissenschaftlichen Forschung, Project no. N212-NAN).
   Financial support of a technician and consumables associated with the
   set up of the STYJOBS EDECTA Cohort.
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NR 31
TC 103
Z9 103
U1 1
U2 14
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1930-7381
EI 1930-739X
J9 OBESITY
JI Obesity
PD JAN
PY 2013
VL 21
IS 1
BP E71
EP E77
DI 10.1002/oby.20061
PG 7
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 187AE
UT WOS:000322086900010
PM 23401248
OA Bronze
DA 2025-06-11
ER

PT J
AU Canz, MJ
   Baguña-Torres, J
   Huerta, J
   Isla-Magrané, H
   Zufiaurre-Seijo, M
   Salas, A
   Hernandez, C
   Simó, R
   García-Arumí, J
   Herance, JR
   Bogdanov, P
   Duarri, A
AF Canz, Maria Jose
   Baguna-Torres, Julia
   Huerta, Jordi
   Isla-Magrane, Helena
   Zufiaurre-Seijo, Maddalen
   Salas, Anna
   Hernandez, Cristina
   Simo, Rafael
   Garcia-Arumi, Jose
   Herance, Jose Raul
   Bogdanov, Patricia
   Duarri, Anna
TI Diabetic retinopathy features in lund MetS rats
SO EXPERIMENTAL EYE RESEARCH
LA English
DT Article
DE Diabetic retinopathy; Neurodegeneration; Neurovascular unit; Metabolic
   syndrome; Retina
ID OXIDATIVE STRESS; ADHESION MOLECULE-1; MACULAR EDEMA; COLOR-VISION;
   CELL; DYSFUNCTION; RETINA; MODELS; GENE
AB The Lund MetS rat (BBDR.cg-Leprdb/db.cp/LundRj) is a novel animal model that has a congenic leptin receptor deficiency (LepR-/-) and males exhibit a variety of metabolic abnormalities mimicking the human metabolic syndrome, including hyperglycemia, dyslipidemia, severe obesity, and a type 2 diabetes-like condition from weeks of age. However, whether Lund MetS rats (LM rats) develop diabetic retinopathy is still unknown. The purpose is to investigate the features of diabetic retinopathy in this model. In this study, male LM rats aged 15 and 30 weeks were analyzed for pathological retinal changes, including vasculopathy, inflammation, reactive gliosis, oxidative stress, and neurodegeneration features on the retinas by histological, immunohistochemical, and gene and protein expression analysis. Compared with the non-diabetic LM rats, diabetic LM rats, mainly 30 weeks of age, had a decrease in retinal thickness and loss of retinal ganglion cells and photoreceptors, indicating retinal neurodegeneration. They also presented an increase in VEGF-A expression, Endra, Icam-1, Vcam-1, and Endrb vascular genes, and albumin suggesting neurovascular unit dysfunction. Furthermore, retinas presented reactive gliosis and infiltration of microglia, TNF-alpha-positive vessels and expressed elevated levels of inflammatory genes Tnf-alpha, IL-18 and IL-6, and oxidative stress markers Sod2 and 8-hydroxy-2-deoxyguanosine (8-OHdG). Our results suggest that diabetic LM rats reproduce the early neurodegenerative and altered neurovascular features that also occur in the human diabetic eye.
C1 [Canz, Maria Jose; Isla-Magrane, Helena; Zufiaurre-Seijo, Maddalen; Salas, Anna; Garcia-Arumi, Jose; Duarri, Anna] Vall dHebron Res Inst, Ophthalmol Res Grp, Barcelona 08035, Spain.
   [Baguna-Torres, Julia; Herance, Jose Raul; Bogdanov, Patricia] Vall dHebron Res Inst, Med Mol Imaging Res Grp, Barcelona 08035, Spain.
   [Huerta, Jordi; Hernandez, Cristina; Simo, Rafael; Bogdanov, Patricia] Vall dHebron Res Inst, Diabet & Metab Res Unit, Barcelona 08035, Spain.
   [Hernandez, Cristina; Simo, Rafael; Bogdanov, Patricia] Inst Salud Carlos III ISCIII, Ctr Invest Biomed Red Diabet & Enfermedades Metab, Madrid 28029, Spain.
   [Garcia-Arumi, Jose] Univ Autonoma Barcelona, Dept Med & Ophthalmol, Bellaterra 08193, Spain.
   [Herance, Jose Raul] Inst Salud Carlos III ISCIII, CIBER BBN ISCIII, Madrid 28040, Spain.
C3 Autonomous University of Barcelona; Hospital Universitari Vall d'Hebron;
   Vall d'Hebron Institut de Recerca (VHIR); Autonomous University of
   Barcelona; Hospital Universitari Vall d'Hebron; Vall d'Hebron Institut
   de Recerca (VHIR); Autonomous University of Barcelona; Hospital
   Universitari Vall d'Hebron; Vall d'Hebron Institut de Recerca (VHIR);
   CIBER - Centro de Investigacion Biomedica en Red; CIBERDEM; Autonomous
   University of Barcelona; CIBER - Centro de Investigacion Biomedica en
   Red; CIBERBBN
RP Duarri, A (corresponding author), Vall dHebron Res Inst, Ophthalmol Res Grp, Barcelona 08035, Spain.; Bogdanov, P (corresponding author), Vall dHebron Res Inst, Diabet & Metab Res Unit, Barcelona 08035, Spain.
EM patricia.bogdanov@vhir.org; anna.duarri@vhir.org
RI Camacho, José/Q-3416-2016; Bogdanov, Patricia/AAF-7831-2021; Torres,
   Julia/JHT-7843-2023; Isla, Helena/HNJ-5145-2023; Duarri,
   Anna/K-2811-2017
OI Bogdanov, Patricia/0000-0003-0669-4958; Herance, Jose
   Raul/0000-0001-7178-3290; Baguna Torres, Julia/0000-0001-8621-3549
FU Instituto de Salud Carlos III [PI20/01588, PI22/01747]; Agencia Gestio
   Ajuts Universitaris i de Recerca [2017SGR1303]; Ministerio de Ciencia
   Innovacion, Gobierno de Espana [PID2022-138544OB-100,
   PID2021-122807OB-C32]
FX This research project was funded by grants from Instituto de Salud
   Carlos III (PI20/01588 and PI22/01747), Agencia Gestio Ajuts
   Universitaris i de Recerca (2017SGR1303), and Ministerio de Ciencia
   Innovacion, Gobierno de Espana (PID2022-138544OB-100 and
   PID2021-122807OB-C32).
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NR 86
TC 1
Z9 1
U1 4
U2 4
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 0014-4835
EI 1096-0007
J9 EXP EYE RES
JI Exp. Eye Res.
PD MAR
PY 2025
VL 252
AR 110274
DI 10.1016/j.exer.2025.110274
EA FEB 2025
PG 13
WC Ophthalmology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Ophthalmology
GA X8F2C
UT WOS:001427630400001
PM 39923911
OA hybrid
DA 2025-06-11
ER

PT J
AU ON'Kin, JBKL
   Longo-Mbenza, B
   Tchokonte-Nana, V
   Okwe, AN
   Kabangu, NK
AF ON'Kin, Jean Bosco Kasiam Lasi
   Longo-Mbenza, Benjamin
   Tchokonte-Nana, Venant
   Okwe, Augustin Nge
   Kabangu, Nelly Kangola
TI Hyperbolic relation between beta-cell function and insulin sensitivity
   for type 2 diabetes mellitus, malaria, influenza, Helicobacter
   pylori, Chlamydia pneumoniae, and hepatitis C virus
   infection-induced inflammation/oxidative stress and temporary insulin
   resistance in Central Africans
SO TURKISH JOURNAL OF MEDICAL SCIENCES
LA English
DT Article
DE Insulin resistance; type 2 diabetes; inflammation; sub-Saharan Africa;
   homeostatic model assessment
ID HOMEOSTASIS MODEL ASSESSMENT; METABOLIC SYNDROME; GLUCOSE-TOLERANCE;
   HEART-DISEASE; RISK-FACTORS; PREVALENCE; STROKE; ATHEROSCLEROSIS;
   PHENOTYPE; FREQUENCY
AB Background/aim: We calculated the homeostatic model assessment (HOMA) for estimating insulin sensitivity and beta-cell function in normal, healthy nondiabetics with infections (malaria, influenza, HIV, Helicobacter pylori, Chlamydia pneumoniae, and hepatitis C virus), type 2 diabetic black patients, and healthy controls from Kinshasa, DR Congo.
   Materials and methods: A case-control study was carried out between 2006 and 2007 for black Central African participants managed for HOMA.
   Results: In total, 219 patients and 110 healthy controls were matched for sex and age. The hyperbolic product for 85 infected patients occupied an intermediate position between the hyperbolic product for 110 controls and that of 134 type 2 diabetics. Inflammation/oxidative stress was present in all infected patients, as well as in the type 2 diabetics. Of the patients, 39.3% and 49.8% had insulin resistance and metabolic syndrome, respectively. Insulin resistance was more prevalent in nondiabetics with inflammation/oxidative stress (47.1%; P = 0.041) than in type 2 diabetics (34.3%). Type 2 diabetics had higher insulin sensitivity and lower beta-cell function but a similar HOMA-IR score.
   Conclusion: We recommend the assessment of insulin resistance in Central African patients with severe infections and type 2 diabetes.
C1 [ON'Kin, Jean Bosco Kasiam Lasi; Longo-Mbenza, Benjamin] Univ Kinshasa, Dept Internal Med, Kinshasa, DEM REP CONGO.
   [Longo-Mbenza, Benjamin] Univ President Kasa Vubu, Boma, DEM REP CONGO.
   [Longo-Mbenza, Benjamin; Okwe, Augustin Nge; Kabangu, Nelly Kangola] LOMO Med Ctr, Biostat Unit, Kinshasa, DEM REP CONGO.
   [Longo-Mbenza, Benjamin; Okwe, Augustin Nge; Kabangu, Nelly Kangola] Heart Africa Ctr Cardiol, Kinshasa, DEM REP CONGO.
   [Tchokonte-Nana, Venant] Stellenbosch Univ, Fac Med & Hlth Sci, Islet & MSK Res Grp, Tygerberg, South Africa.
C3 Universite de Kinshasa; Stellenbosch University
RP Tchokonte-Nana, V (corresponding author), Stellenbosch Univ, Fac Med & Hlth Sci, Islet & MSK Res Grp, Tygerberg, South Africa.
EM venant.tnana@gmail.com
RI Tchokonte-Nana, Venant/L-3364-2016
OI Tchokonte-Nana, Venant/0000-0003-2240-3735
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NR 45
TC 5
Z9 5
U1 0
U2 3
PU Tubitak Scientific & Technological Research Council Turkey
PI ANKARA
PA ATATURK BULVARI NO 221, KAVAKLIDERE, TR-06100 ANKARA, TURKIYE
SN 1300-0144
EI 1303-6165
J9 TURK J MED SCI
JI Turk. J. Med. Sci.
PY 2017
VL 47
IS 6
BP 1834
EP 1841
DI 10.3906/sag-1608-48
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA FR2GD
UT WOS:000418884300025
PM 29306246
OA Bronze
DA 2025-06-11
ER

PT J
AU Di Marzo, V
AF Di Marzo, Vincenzo
TI Targeting the endocannabinoid system: to enhance or reduce?
SO NATURE REVIEWS DRUG DISCOVERY
LA English
DT Review
ID ACID AMIDE HYDROLASE; CB1 RECEPTOR ANTAGONIST; TRANSPORT INHIBITOR
   AM404; ENDOGENOUS LIGAND 2-ARACHIDONOYLGLYCEROL; PERIPHERAL CANNABINOID
   RECEPTOR; CARDIOMETABOLIC RISK-FACTORS; ALLERGIC CONTACT-DERMATITIS;
   STRESS-INDUCED ACTIVATION; ANANDAMIDE-TRANSPORT; IN-VIVO
AB As our understanding of the endocannabinoids improves, so does the awareness of their complexity. During pathological states, the levels of these mediators in tissues change, and their effects vary from those of protective endogenous compounds to those of dysregulated signals. These observations led to the discovery of compounds that either prolong the lifespan of endocannabinoids or tone down their action for the potential future treatment of pain, affective and neurodegenerative disorders, gastrointestinal inflammation, obesity and metabolic dysfunctions, cardiovascular conditions and liver diseases. When moving to the clinic, however, the pleiotropic nature of endocannabinoid functions will require careful judgement in the choice of patients and stage of the disorder for treatment.
C1 CNR, Inst Biomol Chem, Endocannabinoid Res Grp, I-80078 Naples, Italy.
C3 Consiglio Nazionale delle Ricerche (CNR)
RP Di Marzo, V (corresponding author), CNR, Inst Biomol Chem, Endocannabinoid Res Grp, Via Campi,Flegrei 34, I-80078 Naples, Italy.
EM vdimarzo@icmib.na.cnr.it
RI Di Marzo, Vincenzo/AAD-7742-2019
OI Di Marzo, Vincenzo/0000-0002-1490-3070
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NR 211
TC 663
Z9 722
U1 2
U2 89
PU NATURE RESEARCH
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 1474-1776
EI 1474-1784
J9 NAT REV DRUG DISCOV
JI Nat. Rev. Drug Discov.
PD MAY
PY 2008
VL 7
IS 5
BP 438
EP 455
DI 10.1038/nrd2553
PG 18
WC Biotechnology & Applied Microbiology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Pharmacology & Pharmacy
GA 294QF
UT WOS:000255419900017
PM 18446159
DA 2025-06-11
ER

PT J
AU Diaz, A
   Muñoz-Arenas, G
   Caporal-Hernandez, K
   Vazquez-Roque, R
   Lopez-Lopez, G
   Kozina, A
   Espinosa, B
   Flores, G
   Treviño, S
   Guevara, J
AF Diaz, Alfonso
   Munoz-Arenas, Guadalupe
   Caporal-Hernandez, Karen
   Vazquez-Roque, Ruben
   Lopez-Lopez, Gustavo
   Kozina, Anna
   Espinosa, Blanca
   Flores, Gonzalo
   Trevino, Samuel
   Guevara, Jorge
TI Gallic acid improves recognition memory and decreases
   oxidative-inflammatory damage in the rat hippocampus with metabolic
   syndrome
SO SYNAPSE
LA English
DT Article
DE dendritic spines; Golgi-Cox stain; interleukins; novel objects;
   polyphenols; reactive oxygen species
ID STRESS; STREPTOZOTOCIN; GLUCOSE; NEUROTROPHINS; ASSOCIATION;
   IMPAIRMENTS; ACTIVATION; PLASTICITY; EXPOSURE; DEFICITS
AB Metabolic syndrome (MS) results from excessive consumption of high-calorie foods and sedentary lifestyles. Clinically, insulin resistance, abdominal obesity, hyperglycemia, dyslipidemia, and hypertension are observed. MS has been considered a risk factor in the development of dementia. In the brain, a metabolically impaired environment generates oxidative stress and excessive production of pro-inflammatory cytokines that deteriorate the morphology and neuronal function in the hippocampus, leading to cognitive impairment. Therapeutic alternatives suggest that phenolic compounds can be part of the treatment for neuropathies and metabolic diseases. In recent years, the use of Gallic Acid (GA) has demonstrated antioxidant and anti-inflammatory effects that contribute to neuroprotection and memory improvement in animal models. However, the effect of GA on hippocampal neurodegeneration and memory impairment under MS conditions is still unclear. In this work, we administered GA (20 mg/kg) for 60 days to rats with MS. The results show that GA treatment improved zoometric and biochemical parameters, as well as the recognition memory, in animals with MS. Additionally, GA administration increased hippocampal dendritic spines and decreased oxidative stress and inflammation. Our results show that GA treatment improves metabolism: reducing the oxidative and inflammatory environment that facilitates the recovery of the neuronal morphology in the hippocampus of rats with MS. Consequently, the recognition of objects by these animals, suggesting that GA could be used therapeutically in metabolic disorders that cause dementia.
C1 [Diaz, Alfonso; Munoz-Arenas, Guadalupe; Caporal-Hernandez, Karen; Lopez-Lopez, Gustavo; Trevino, Samuel] Benemerita Univ Autonoma Puebla, Fac Ciencias Quim, Puebla, Mexico.
   [Vazquez-Roque, Ruben; Flores, Gonzalo] Benemerita Univ Autonoma Puebla, Inst Fisiol, Lab Neuropsiquiatria, Puebla, Mexico.
   [Kozina, Anna] Univ Nacl Autonoma Mexico, Inst Quim, Ciudad De Mexico, Mexico.
   [Espinosa, Blanca] ICV, Dept Bioquim, Inst Nacl Enfermedades Resp, Ciudad De Mexico, Mexico.
   [Guevara, Jorge] Univ Nacl Autonoma Mexico, Fac Med, Dept Bioquim, Ciudad De Mexico, Mexico.
C3 Benemerita Universidad Autonoma de Puebla; Benemerita Universidad
   Autonoma de Puebla; Universidad Nacional Autonoma de Mexico; Universidad
   Nacional Autonoma de Mexico
RP Guevara, J (corresponding author), Univ Nacl Autonoma Mexico, Fac Med, Dept Bioquim, Ciudad De Mexico, Mexico.
EM jorge.guevara@comunidad.unam.mx
RI Vazquez Roque, Ruben/L-5757-2013; Flores, Gonzalo/B-1807-2014
OI Guevara, Jorge/0000-0003-3428-3179; Diaz, Alfonso/0000-0003-4092-6636;
   Flores, Gonzalo/0000-0002-4100-2104; Munoz-Arenas,
   Guadalupe/0000-0002-7622-5308; Vazquez Roque, Ruben/0000-0002-2712-5714;
   Kozina, Anna/0000-0002-4287-2953
FU VIEP-BUAP grant [DIFA-NAT18-G, TEMS-NAT18-I]; PAPIIT-UNAM [IN214117]
FX Funding for this study was provided by grants from VIEP-BUAP grant (No.
   DIFA-NAT18-G) to AD, (No. TEMS-NAT18-I) to ST and PAPIIT-UNAM (IN214117)
   to GJ. None of the funding institutions had any further role in the
   study design, the collection of data, analyses, and interpretation of
   data, writing of the report or in the interpretation of data, and the
   decision to submit the paper for publication
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NR 87
TC 34
Z9 35
U1 0
U2 10
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0887-4476
EI 1098-2396
J9 SYNAPSE
JI Synapse
PD FEB
PY 2021
VL 75
IS 2
AR e22186
DI 10.1002/syn.22186
EA SEP 2020
PG 17
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA PC9OG
UT WOS:000564511200001
PM 32780904
DA 2025-06-11
ER

PT J
AU Miller, KG
   Gianaros, PJ
   Kamarck, TW
   Anderson, BA
   Muldoon, MF
   Manuck, SB
AF Miller, Karissa G.
   Gianaros, Peter J.
   Kamarck, Thomas W.
   Anderson, Barbara A.
   Muldoon, Matthew F.
   Manuck, Stephen B.
TI Cortisol activity partially accounts for a relationship between
   community socioeconomic position and atherosclerosis
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE Cortisol; HPA; Community socioeconomic position; SES; Atherosclerosis;
   IMT
ID INTIMA-MEDIA THICKNESS; CORONARY-ARTERY-DISEASE; DIURNAL CORTISOL;
   METABOLIC SYNDROME; SALIVARY CORTISOL; NEIGHBORHOOD DISADVANTAGE;
   HEART-DISEASE; ASSOCIATION; STRESS; RISK
AB Compared to others, individuals living in communities of socioeconomic disadvantage experience more atherosclerotic cardiovascular disease (CVD) and a greater extent of preclinical atherosclerosis. Although the mechanisms underlying these associations remain unclear, it is widely hypothesized that alterations in normative cortisol release from the Hypothalamic Pituitary Adrenal (HPA) axis may play a role in linking lower community socioeconomic position (C-SEP) to CVD risk. The current study examined this hypothesis in relation to a marker of preclinical atherosclerosis among 488 healthy midlife adults (30-54 years, Mean age= 43, 52% Female, 81% White). All participants were employed and without clinical CVD. C-SEP was estimated from census tract data, and atherosclerosis was measured as intima-medial thickness of the carotid arteries (cIMT) by duplex ultrasonography. Four indicators of HPA activity [cortisol at awakening and the cortisol awakening response (CAR), rate of diurnal decline in cortisol (diurnal slope), and total output expressed as area under the curve (AUC)] were derived from salivary cortisol measurements obtained from 5 samples on each of 3 working days. Path analyses were used to examine associations of C-SEP with cIMT and HPA activity and to test whether individual differences in HPA activity could account for any association of C-SEP with cIMT using bootstrapping (5000 iterations). All models were adjusted for age, sex, race, and composite measures of both individual-level socioeconomic position (income, education, occupation), and cardiometabolic risk (systolic and diastolic blood pressure, waist circumference, fasting lipids and glucose). Lower C-SEP was related to both greater cIMT (b = -0.004, p = .021) and a flatter diurnal slope of cortisol (b = -0.001, p = .039). An indirect effect showed attenuated diurnal slope to partially mediate the relationship between C-SEP and cIMT (95% CI = -0.0018 to -0.0001), and a residual direct effect of C-SEP on cIMT remained significant (95% CI = -0.0097 to -0.004). These results suggest that low C-SEP associations with preclinical atherosclerosis may be due in part to correlated variation in adrenocortical activity.
C1 [Miller, Karissa G.] Calif State Univ Long Beach, Dept Psychol, 1250 Bellflower Blvd, Long Beach, CA 90808 USA.
   [Gianaros, Peter J.; Kamarck, Thomas W.; Anderson, Barbara A.; Manuck, Stephen B.] Univ Pittsburgh, Dept Psychol, Pittsburgh, PA 15260 USA.
   [Muldoon, Matthew F.] Univ Pittsburgh, Sch Med, Div Cardiol, Pittsburgh, PA 15261 USA.
C3 California State University System; California State University Long
   Beach; Pennsylvania Commonwealth System of Higher Education (PCSHE);
   University of Pittsburgh; Pennsylvania Commonwealth System of Higher
   Education (PCSHE); University of Pittsburgh
RP Miller, KG (corresponding author), Calif State Univ Long Beach, Dept Psychol, 1250 Bellflower Blvd, Long Beach, CA 90808 USA.
EM karissa.miller@csulb.edu; gianaros@pitt.edu; tkam@pitt.edu;
   baa1@pitt.edu; mfm10@pitt.edu; manuck@pitt.edu
FU NIH [P01 HL040962, RO1 AG056043]; National Heart Lung and Blood
   Institute [P01HL040962] Funding Source: NIH RePORTER
FX We wish to acknowledge the collaboration of Dr. Clemens Kirschbaum in
   the analysis of salivary cortisol samples collected for this studyThis
   research was supported by NIH Grant P01 HL040962 and RO1 AG056043.
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NR 62
TC 3
Z9 3
U1 0
U2 9
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
EI 1873-3360
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD SEP
PY 2021
VL 131
AR 105292
DI 10.1016/j.psyneuen.2021.105292
EA JUN 2021
PG 9
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA UJ3YJ
UT WOS:000691224600018
PM 34144404
OA hybrid
DA 2025-06-11
ER

PT J
AU Marycz, K
   Michalak, I
   Kocherova, I
   Maredziak, M
   Weiss, C
AF Marycz, Krzysztof
   Michalak, Izabela
   Kocherova, Ievgeniia
   Maredziak, Monika
   Weiss, Christine
TI The Cladophora glomerata Enriched by Biosorption Process in
   Cr(III) Improves Viability, and Reduces Oxidative Stress and Apoptosis
   in Equine Metabolic Syndrome Derived Adipose Mesenchymal Stromal Stem
   Cells (ASCs) and Their Extracellular Vesicles (MV's)
SO MARINE DRUGS
LA English
DT Article
DE algae extract; Cladophora glomerata; biosorption; trivalent chromium;
   EMS; ASCs
ID TNF-ALPHA; TISSUE; DIFFERENTIATION; TOLERANCE; CHROMIUM; GLUCOSE;
   HORSES; PONIES; BLOOD; ALGAE
AB This study investigated in vitro effects of freshwater alga Cladophora glomerata water extract enriched during a biosorption process in Cr(III) trivalent chromium and chromium picolinate on adipose-derived mesenchymal stromal stem cells (ASCs) and extracellular microvesicles (MVs) in equine metabolic syndrome-affected horses. Chemical characterisation of natural Cladophora glomerata was performed with special emphasis on: vitamin C, vitamin E, total phenols, fatty acids, free and protein-bound amino acids as well as measured Cr in algal biomass. To examine the influence of Cladophora glomerata water extracts, in vitro viability, oxidative stress factor accumulation, apoptosis, inflammatory response, biogenesis of mitochondria, autophagy in ASCs of EMS and secretory activity manifested by MV release were investigated. For this purpose, various methods of molecular biology and microscopic observations (i.e., immunofluorescence staining, SEM, TEM, FIB observations, mRNA and microRNA expression by RT-qPCR) were applied. The extract of Cladophora glomerata enriched with Cr(III) ions reduced apoptosis and inflammation in ASCs of EMS horses through improvement of mitochondrial dynamics, decreasing of PDK4 expression and reduction of endoplastic reticulum stress. Moreover, it was found, that Cladophora glomerata and Cr(III) induce antioxidative protection coming from enhanced SOD activity Therefore, Cladophora glomerata enriched with Cr(III) ions might become an interesting future therapeutic agent in the pharmacological treatment of EMS horses.
C1 [Marycz, Krzysztof; Kocherova, Ievgeniia; Maredziak, Monika] Wroclaw Univ Environm & Life Sci, Dept Expt Biol, Chelmonskiego 38 C, PL-50630 Wroclaw, Poland.
   [Marycz, Krzysztof] Wroclawskie Ctr Badan EIT, Stablowicka 147 St, PL-54066 Wroclaw, Poland.
   [Michalak, Izabela] Wroclaw Univ Sci & Technol, Dept Adv Mat Technol, Fac Chem, Smoluchowskiego 25 St, PL-50372 Wroclaw, Poland.
   [Weiss, Christine] PferdePraxis Dr Med Vet Daniel Weiss, Postmatte 14, CH-8807 Freienbach, Switzerland.
C3 Wroclaw University of Environmental & Life Sciences; Wroclaw University
   of Science & Technology
RP Marycz, K (corresponding author), Wroclaw Univ Environm & Life Sci, Dept Expt Biol, Chelmonskiego 38 C, PL-50630 Wroclaw, Poland.; Marycz, K (corresponding author), Wroclawskie Ctr Badan EIT, Stablowicka 147 St, PL-54066 Wroclaw, Poland.
EM krzysztof.marycz@upwr.edu.pl; izabela.michalak@pwr.edu.pl;
   kocherova.evgenia@gmail.com; monika.maredziak@upwr.edu.pl;
   d.weiss@horsedoc.ch
RI Kocherova, Ievgeniia/AAJ-2569-2020; Michalak, Izabela/P-3770-2015
OI Kocherova, Ievgeniia/0000-0003-2561-9750; Michalak,
   Izabela/0000-0001-8084-9642
FU National Science Centre in Poland [2015/18/E/NZ9/00607]; Wroclaw Centre
   of Biotechnology, Leading National Research Centre (KNOW, Krajowy
   Naukowy Osrodek Wiodacy) program
FX This project is financed in the framework of grant entitled "The effect
   of bioactive algae enriched by biosorption on the certain minerals such
   as Cr(III), Mg(II) and Mn(II) on the status of glucose in the course of
   metabolic syndrome horses. Evaluation in vitro and in vivo"
   (2015/18/E/NZ9/00607) attributed by The National Science Centre in
   Poland. Additionally, we acknowledge the Wroclaw Centre of
   Biotechnology, Leading National Research Centre (KNOW, Krajowy Naukowy
   Osrodek Wiodacy) program for years 2014-2018 for covering the
   publication fee.
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NR 42
TC 35
Z9 36
U1 2
U2 16
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1660-3397
J9 MAR DRUGS
JI Mar. Drugs
PD DEC
PY 2017
VL 15
IS 12
AR 385
DI 10.3390/md15120385
PG 18
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA FR6ZR
UT WOS:000419216500022
PM 29292726
OA gold, Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Aslanidi, OV
   Clayton, RH
   Lambert, JL
   Holden, AV
AF Aslanidi, OV
   Clayton, RH
   Lambert, JL
   Holden, AV
TI Dynamical and cellular electrophysiological mechanisms of ECG changes
   during ischaemia
SO JOURNAL OF THEORETICAL BIOLOGY
LA English
DT Article
DE Luo-Rudy model; transmural propagation; ECG; ischaemia; ST depression
ID ACTION-POTENTIAL DURATION; VENTRICULAR-FIBRILLATION; REGIONAL
   DIFFERENCES; MYOCARDIAL-ISCHEMIA; M-CELLS; SUBENDOCARDIAL ISCHEMIA;
   CARDIAC FIBRILLATION; COMPUTATIONAL MODEL; SYNDROME-X; PIG-HEART
AB The interpretation of normal and pathological electrocardiographic (ECG) patterns in terms of the underlying cellular and tissue electrophysiology is rudimentary, as the existing theories rely on geometrical aspects. We relate effects of sub-endocardial ischaemia on the ST-segment depression in ECG to patterns of transmural action potential propagation in a one-dimensional virtual ventricular wall. Our computational study exposes two electrophysiological mechanisms of ST depression: dynamic-predominantly positive spatial gradients in the membrane potential during abnormal repolarization of the wall, produced by action potential duration changes in the ischaemic region; and static-a negative spatial gradient of the resting membrane potential between the normal and ischaemic regions. Hyperkalaemia is the major contributor to both these mechanisms at the cellular level. These results complement simulations of the effects of cardiac geometry on the ECG, and dissect spatio-temporal and cellular electrophysiological mechanisms of ST depression seen in sub-endocardial ischaemia. (c) 2005 Elsevier Ltd. All rights reserved.
C1 Univ Leeds, Sch Biomed Sci, Leeds LS2 9JT, W Yorkshire, England.
   Univ Sheffield, Dept Comp Sci, Sheffield S1 4DP, S Yorkshire, England.
   Univ Leeds, Sch Med, Leeds LS2 9JT, W Yorkshire, England.
C3 University of Leeds; University of Sheffield; University of Leeds
RP Univ Leeds, Sch Biomed Sci, Leeds LS2 9JT, W Yorkshire, England.
EM arun@cbiol.leeds.ac.uk
RI Clayton, Richard/CAF-3400-2022
OI Aslanidi, Oleg/0000-0003-4813-7682; Clayton, Richard/0000-0002-8438-7518
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NR 46
TC 26
Z9 30
U1 0
U2 5
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 0022-5193
EI 1095-8541
J9 J THEOR BIOL
JI J. Theor. Biol.
PD DEC 21
PY 2005
VL 237
IS 4
BP 369
EP 381
DI 10.1016/j.jtbi.2005.04.022
PG 13
WC Biology; Mathematical & Computational Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics; Mathematical & Computational
   Biology
GA 989JE
UT WOS:000233667900004
PM 15979649
DA 2025-06-11
ER

PT J
AU Tien, N
   Wu, TY
   Lai, JN
   Lin, CL
   Hsiao, YC
   Khaw, JY
   Lim, YP
AF Tien, Ni
   Wu, Tien-Yuan
   Lai, Jung-Nien
   Lin, Cheng-Li
   Hsiao, Yu-Chi
   Khaw, Jie-Yee
   Lim, Yun-Ping
TI Influences of antidepressant medications on the risk of developing
   hyperlipidemia in patients with depression by a population-based cohort
   study and on in vitro hepatic lipogenic-related gene expression
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Depression; Antidepressant medications; Hyperlipidemia; Cohort study;
   Lipogenesis
ID SEROTONIN REUPTAKE INHIBITORS; DENSITY-LIPOPROTEIN CHOLESTEROL;
   CORONARY-HEART-DISEASE; METABOLIC SYNDROME; CEREBROVASCULAR EVENTS;
   SERUM CONCENTRATIONS; STROKE; ASSOCIATION; DISORDER; METAANALYSIS
AB Background: Depression increases the risk of cardiovascular disease (CVD). The association between antidepressant medications (ADMs) and CVD remains controversial. Hyperlipidemia is a risk factor for CVD. We conducted a nationwide population-based retrospective cohort study to examine depression and ADM use on the risk of developing hyperlipidemia. The effects of ADMs on the expression of lipogenesis-related hepatic genes were also evaluated.
   Methods: We obtained data from the Longitudinal Health Insurance Database of Taiwan on patients with new-onset depression and a comparison cohort without depression. A Cox proportional hazards regression model was used to analyze the differences in the risk of developing hyperlipidemia between these two cohorts. We also examined the influence of ADMs on the expression of lipogenesis-related hepatic genes.
   Results: After adjustment for comorbidities and confounding factors, the case group (N = 38,322) had a higher risk for hyperlipidemia than that of the control cohort (N = 38,322) [adjusted hazards ratio (aHR)=1.16]. Patients with depression who did not receive ADM therapy exhibited a significantly higher risk of hyperlipidemia (aHR = 1.61). However, in patients with depression treated with ADMs, the risk of developing hyperlipidemia was significantly lowered compared to the patients without ADMs (all aHR < 0.81). Gene expression analysis indicated that ADMs downregulated the expression of lipogenesis-related hepatic genes.
   Limitations: Unmeasured confounding risk factors for hyperlipidemia might not have been included in the study.
   Conclusions: ADMs reduced hyperlipidemia risk in patients with depression, partly by downregulating the expression of lipogenesis-related genes and improving the patients' lipid profiles. Early diagnosis and management of hyperlipidemia would further facilitate the prevention of CVD.
C1 [Tien, Ni] China Med Univ Hosp, Dept Lab Med, Taichung, Taiwan.
   [Tien, Ni] China Med Univ, Dept Med Lab Sci & Biotechnol, Taichung, Taiwan.
   [Wu, Tien-Yuan] Buddhist Tzu Chi Med Fdn, Taichung Tzu Chi Hosp, Dept Pharm, Taichung, Taiwan.
   [Wu, Tien-Yuan] Tzu Chi Univ, Sch Med, Dept Pharmacol, Hualien, Taiwan.
   [Lai, Jung-Nien] China Med Univ Hosp, Dept Chinese Med, Taichung, Taiwan.
   [Lai, Jung-Nien] China Med Univ, Coll Chinese Med, Sch Chinese Med, Taichung, Taiwan.
   [Lin, Cheng-Li] China Med Univ Hosp, Management Off Hlth Data, Taichung, Taiwan.
   [Hsiao, Yu-Chi; Khaw, Jie-Yee; Lim, Yun-Ping] China Med Univ, Coll Pharm, Dept Pharm, 100,Sec 1,Jingmao Rd, Taichung 406040, Taiwan.
   [Lim, Yun-Ping] China Med Univ Hosp, Dept Internal Med, Taichung, Taiwan.
   [Lim, Yun-Ping] China Med Univ Hosp, Dept Med Res, Taichung, Taiwan.
C3 China Medical University Taiwan; China Medical University Hospital -
   Taiwan; China Medical University Taiwan; Buddhist Tzu Chi General
   Hospital; Taichung Tzu Chi Hospital; Tzu Chi University; China Medical
   University Taiwan; China Medical University Hospital - Taiwan; China
   Medical University Taiwan; China Medical University Taiwan; China
   Medical University Hospital - Taiwan; China Medical University Taiwan;
   China Medical University Taiwan; China Medical University Hospital -
   Taiwan; China Medical University Taiwan; China Medical University
   Hospital - Taiwan
RP Wu, TY (corresponding author), Buddhist Tzu Chi Med Fdn, Taichung Tzu Chi Hosp, Dept Pharm, Taichung, Taiwan.; Wu, TY (corresponding author), Tzu Chi Univ, Sch Med, Dept Pharmacol, Hualien, Taiwan.; Lim, YP (corresponding author), China Med Univ, Coll Pharm, Dept Pharm, 100,Sec 1,Jingmao Rd, Taichung 406040, Taiwan.
EM limyp@mail2000.com.tw
RI Wu, Tien-Yuan/AAV-6964-2020; Liao, Yu-Chi/AAT-1357-2021
OI Lin, Cheng-Li/0000-0001-9926-3668
FU Ministry of Science and Technology, Taiwan, R.O.C.
   [MOST110-2320-B-039-016-MY3]; China Medical University Hospital,
   Taichung, Taiwan [DMR-107-109]; China Medical University, Taichung,
   Taiwan [CMU110-MF-29]; Buddhist Tzu Chi Medical Foundation
   [TTCRD110-28]; Taiwan Ministry of Health and Welfare Clinical Trial
   Center [MOHW110-TDU-B-212-124,004]; MOST Clinical Trial Consortium for
   Stroke [MOST109-2321-B-039-002]; China Medical University Hospital
   [DMR-109-231]; Tseng-Lien Lin Foundation, Taichung, Taiwan
FX This study was supported by the Ministry of Science and Technology,
   Taiwan, R.O.C. (MOST110-2320-B-039-016-MY3); China Medical University
   Hospital, Taichung, Taiwan (DMR-107-109); China Medical University,
   Taichung, Taiwan (CMU110-MF-29); Taichung Tzu Chi Hospital, Buddhist Tzu
   Chi Medical Foundation (TTCRD110-28); and in part by Taiwan Ministry of
   Health and Welfare Clinical Trial Center (MOHW110-TDU-B-212-124,004);
   MOST Clinical Trial Consortium for Stroke (MOST109-2321-B-039-002);
   China Medical University Hospital (DMR-109-231); and Tseng-Lien Lin
   Foundation, Taichung, Taiwan.
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NR 64
TC 4
Z9 4
U1 0
U2 12
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD DEC 1
PY 2021
VL 295
BP 271
EP 283
DI 10.1016/j.jad.2021.08.041
EA SEP 2021
PG 13
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA YE7XT
UT WOS:000741334700036
PM 34482059
OA hybrid
DA 2025-06-11
ER

PT J
AU Garcez, A
   Leite, HM
   Weiderpass, E
   Paniz, VMV
   Watte, G
   Canuto, R
   Olinto, MTA
AF Garcez, Anderson
   Leite, Heloisa Marquardt
   Weiderpass, Elisabete
   Vieira Paniz, Vera Maria
   Watte, Guilherme
   Canuto, Raquel
   Anselmo Olinto, Maria Teresa
TI Basal cortisol levels and metabolic syndrome: A systematic review and
   meta analysis of observational studies
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Review
DE Cortisol; Metabolic syndrome; Observational studies; Systematic review;
   Meta-analysis
ID PITUITARY-ADRENAL AXIS; SALIVARY CORTISOL; CARDIOVASCULAR RISK;
   ASSOCIATION; OBESITY; STRESS; METAANALYSIS; PREVALENCE; LIFE; DEPRESSION
AB Objective: To perform a qualitative synthesis (systematic review) and quantitative analysis (meta-analysis) to summarize the evidence regarding the relationship between basal cortisol levels and metabolic syndrome (MetS) in adults.
   Methods: A systematic search was performed in the PubMed, Embase, and PsycINFO databases for observational studies on the association between basal cortisol levels and MetS. The quality of individual studies was assessed by the Newcastle-Ottawa score. A random effects model was used to report pooled quantitative results and the I-2 statistic was used to assess heterogeneity. Egger's and Begg's tests were used to evaluate publication bias.
   Results: Twenty-six studies (19 cross-sectional and seven case-control) met the inclusion criteria for the systematic review. The majority was classified as having a low risk of bias and used established criteria for the diagnosis of MetS. Twenty-one studies provided data on basal cortisol levels as continuous values and were included in the meta-analysis; they comprised 35 analyses and 11,808 subjects. Pooled results showed no significant difference in basal cortisol levels between subjects with and without MetS (standardized mean difference [SMD] = 0.02, 95% confidence interval [CI] = -0.11 to 0.14). There was high heterogeneity between the studies when all comparisons were considered (I-2 = 83.1%;p < 0.001). Paradoxically, meta-analysis of studies evaluating saliva samples showed no significantly lower basal cortisol levels among subjects with MetS (SMD = -0.18, 95% CI = -0.37 to 0.01), whereas those studies that evaluated serum samples (SMD = 0.11, 95% CI = -0.02 to 0.24) and urine samples (SMD = 0.73, 95% CI = -0.40 to 1.86) showed no significantly higher basal cortisol levels among subjects with MetS. In the subgroup and meta-regression analyses, a significant difference in basal cortisol levels was observed according to study design, population base, age, gender, cortisol level assessment method, and study quality.
   Conclusion: This systematic review and meta-analysis does not reveal any association between basal cortisol levels and MetS based on results of observational studies. The results of a random-effect meta-analysis showed no significant difference in basal cortisol levels between subjects with and without MetS. The present findings should be considered in order to help future studies.
C1 [Garcez, Anderson; Leite, Heloisa Marquardt; Vieira Paniz, Vera Maria; Anselmo Olinto, Maria Teresa] Univ Vale Rio Sinos UNISINOS, Postgrad Program Collect Hlth, Sao Leopoldo, RS, Brazil.
   [Weiderpass, Elisabete] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.
   [Weiderpass, Elisabete] Canc Registry Norway, Inst Populat Based Canc Res, Dept Res, Oslo, Norway.
   [Weiderpass, Elisabete] Univ Tromso, Dept Community Med, Fac Hlth Sci, Tromso, Norway.
   [Weiderpass, Elisabete] Arctic Univ Norway, Univ Tromso, Tromso, Norway.
   [Weiderpass, Elisabete] Folkhalsan Res Ctr, Genet Epidemiol Grp, Helsinki, Finland.
   [Watte, Guilherme] Pavilhao Pereira Filho, Irmandade Santa Casa Misericordia Porto Alegre, Dept Resp Med & Thorac Surg, Porto Alegre, RS, Brazil.
   [Canuto, Raquel] Fed Univ Rio Grande do Sul State UFRGS, Dept Nutr, Porto Alegre, RS, Brazil.
   [Anselmo Olinto, Maria Teresa] Fed Univ Hlth Sci Porto Alegre UFCSPA, Dept Nutr, Porto Alegre, RS, Brazil.
C3 Universidade do Vale do Rio dos Sinos (Unisinos); Karolinska Institutet;
   University of Oslo; UiT The Arctic University of Tromso; UiT The Arctic
   University of Tromso; Folkhalsan Research Center; Universidade Federal
   do Rio Grande do Sul; Universidade Federal de Ciencias da Saude de Porto
   Alegre
RP Olinto, MTA (corresponding author), Univ Vale Rio dos Sinos, Av Unisinos 950,CP 275, BR-93022000 Sao Leopoldo, RS, Brazil.
EM mtolinto@gmail.com
RI Canuto, Raquel/AAV-8688-2020; Garcez, Anderson/AAH-5877-2021; Olinto,
   Maria/AAH-5897-2021; Leite, Heloisa/LFL-2582-2024; Watte,
   G./ABC-7864-2020; Paniz, Vera/AAJ-8450-2020; Weiderpass,
   Elisabete/M-4029-2016
OI Watte, Guilherme/0000-0002-6948-3982; Weiderpass,
   Elisabete/0000-0003-2237-0128; Marquardt Leite,
   Heloisa/0000-0002-5955-2294
FU National Council of Technological and Scientific Development (Conselho
   Nacional de Desenvolvimento Cientifico e Tecnologic - CNPq - Brazilian
   Government) [307257/2013-4]; National Council of Technological and
   Scientific Development - CNPq (Brazilian Government) [207314/2015-2]
FX MTAO was supported by the National Council of Technological and
   Scientific Development (Conselho Nacional de Desenvolvimento Cientifico
   e Tecnologic - CNPq - Brazilian Government) through research
   productivity fellowship under grant agreement number 307257/2013-4. AG
   was supported by the National Council of Technological and Scientific
   Development - CNPq (Brazilian Government) through sandwich doctorate
   fellowship at the Department of Medical Epidemiology and Biostatistics,
   Karolinska Institutet, Stockholm, Sweden under grant number
   207314/2015-2. The funders had no role in the study design, data
   collection and analysis, decision to publish and preparation or approval
   of the manuscript.
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NR 57
TC 14
Z9 14
U1 0
U2 18
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD SEP
PY 2018
VL 95
BP 50
EP 62
DI 10.1016/j.psyneuen.2018.05.023
PG 13
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA GU9YO
UT WOS:000445713400007
PM 29800780
DA 2025-06-11
ER

PT J
AU Ozku, F
   Turkon, H
   Cakir, DU
   Eroglu, M
   Tutunculer, FK
   Faydaci, U
   Ukinç, K
   Asik, M
AF Ozku, Faruk
   Turkon, Hakan
   Cakir, Dilek Ulker
   Eroglu, Mustafa
   Tutunculer, Funda Kirtay
   Faydaci, Umut
   Ukinc, Kubilay
   Asik, Mehmet
TI SERUM ISCHEMIA MODIFIED ALBUMIN LEVELS IN SUBCLINICAL CUSHING'S SYNDROME
SO ACTA MEDICA MEDITERRANEA
LA English
DT Article
DE Ischemia-modified albumin; adrenal incidentaloma; subclinical Cushing's
   syndrome; oxidative stress
ID ADRENAL INCIDENTALOMA
AB Introduction: Subclinical Cushing's syndrome (SCS) is defined as biochemical overt cortisol excess in the absence of the classical signs and symptoms of Cushing's disease. The prevalence of SCS is reported as between approximately 5% and 24% in patients with adrenal incidentalomas (AI). SCS has increased cardiovascular and metabolic risk factors, and metabolic syndrome. Recently some studies demonstrated oxidative stress enhancement in Cushing's disease. Ischemia-modified albumin (IMA) is a marker of ischemia and oxidative stress and is increased in different clinical conditions such as cardiovascular diseases and metabolic syndrome. However, it has not been investigated in the patients with SCS. We aimed to evaluate serum IMA levels in the patients with SCS.
   Materials and methods: A total of 128 patients with AI were included in this study (17 patients with SCS and 111 patients with non-functional adenomas (NFA)). All patients were evaluated for the presence of adrenal masses using adrenal computed tomography (CT) scans. Serum IMA levels were measured by using a calorimetric method.
   Results: Serum IMA levels were significantly higher in SCS patients than in NFA patients (p < 0.05). Serum IMA was significantly correlated with waist circumference, low-density lipoprotein (LDL) levels and SCS. Furthermore, regression analysis revealed that serum IMA levels are independent and positively associated only with SCS.
   Conclusion: We concluded that elevated serum IMA levels might be accepted as a useful marker in patients with SCS. In order to reveal the pathological role of IMA levels in patients with SCS more studies are required.
C1 [Ozku, Faruk] Canakkale Onsekiz Mart Univ, Fac Med, Dept Gen Surg, TR-17100 Canakkale, Turkey.
   [Turkon, Hakan; Cakir, Dilek Ulker; Tutunculer, Funda Kirtay] Canakkale Onsekiz Mart Univ, Fac Med, Dept Med Biochem, TR-17100 Canakkale, Turkey.
   [Eroglu, Mustafa; Ukinc, Kubilay; Asik, Mehmet] Canakkale Onsekiz Mart Univ, Fac Med, Dept Endocrinol, TR-17100 Canakkale, Turkey.
   [Eroglu, Mustafa; Ukinc, Kubilay; Asik, Mehmet] Canakkale Onsekiz Mart Univ, Fac Med, Dept Metab, TR-17100 Canakkale, Turkey.
   [Faydaci, Umut] Near East Univ, Fac Med, Dept Gen Surg, Nicosia, Cyprus.
C3 Canakkale Onsekiz Mart University; Canakkale Onsekiz Mart University;
   Canakkale Onsekiz Mart University; Canakkale Onsekiz Mart University;
   Near East University
RP Turkon, H (corresponding author), Canakkale Onsekiz Mart Univ, Fac Med, Dept Med Biochem, TR-17100 Canakkale, Turkey.
RI Eren, Mehmet/LBI-2705-2024; Eroğlu, Mustafa/AAC-1081-2020; Ukinc,
   KUBILAY/E-7111-2018
OI Ukinc, KUBILAY/0000-0002-4727-7432
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NR 17
TC 0
Z9 0
U1 0
U2 2
PU CARBONE EDITORE
PI PALERMO
PA VIA QUINTINO SELLA, 68, PALERMO, 90139, ITALY
SN 0393-6384
EI 2283-9720
J9 ACTA MEDICA MEDITERR
JI Acta Medica Mediterr.
PY 2016
VL 32
IS 2
BP 463
EP 467
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA DL0QQ
UT WOS:000375338000031
DA 2025-06-11
ER

PT J
AU Milaneschi, Y
   Simonsick, EM
   Vogelzangs, N
   Strotmeyer, ES
   Yaffe, K
   Harris, TB
   Tolea, MI
   Ferrucci, L
   Penninx, BWJH
AF Milaneschi, Yuri
   Simonsick, Eleanor M.
   Vogelzangs, Nicole
   Strotmeyer, Elsa S.
   Yaffe, Kristine
   Harris, Tamara B.
   Tolea, Magdalena I.
   Ferrucci, Luigi
   Penninx, Brenda W. J. H.
CA Hlth Aging Body Composition Study
TI Leptin, Abdominal Obesity, and Onset of Depression in Older Men and
   Women
SO JOURNAL OF CLINICAL PSYCHIATRY
LA English
DT Article
ID BODY-FAT DISTRIBUTION; C-REACTIVE PROTEIN; PLASMA LEPTIN;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; DIABETES-MELLITUS; MAJOR
   DEPRESSION; SEX-DIFFERENCES; ADIPOSE-TISSUE; SERUM LEPTIN
AB Objective: The mechanisms that underlie the association between abdominal obesity and depression risk in older persons are not well known, but the "leptin hypothesis" of depression suggests that leptin resistance may be involved in mood regulation. We tested whether high circulatory concentration of leptin, alone and in combination with visceral adiposity, is associated with onset of depression in a sample of older persons.
   Method: Participants were 1,220 men and 1,282 women aged 70-79 years and enrolled in the Health, Aging, and Body Composition study. Serum concentration of leptin and abdominal visceral fat, ascertained by computed tomography, were assessed at baseline (April 1997-June 1998). Onset of depression, the primary outcome measure, was defined as a Center for Epidemiologic Studies-Depression Scale 10-item score >= 10 and/or new antidepressant medication use at any annual visit over a 5-year follow-up.
   Results: Higher leptin level was associated with the risk of depression onset in men with high levels of visceral fat (hazard ratio [HR] =1.25; 95% CI, 1.06-1.46; P = .01) but not in those with normal visceral fat (HR = 0.98; 95% CI, 0.80-1.19; P = .80) (leptin-by-visceral fat, P = .04). No interaction between leptin and visceral fat was detected in the analysis focusing on women (P = .90).
   Conclusions: In older men, high leptin level was associated with an increased onset of depressive symptoms, especially in the presence of abdominal obesity, suggesting that underlying leptin resistance may play a role in this link. Differences in visceral fat levels and metabolic consequences may explain the absence of this association in women. These findings suggest a potential biological link between depression, obesity, and their joint association with negative health outcomes. J Clin Psychiatry 2012;73(9):1205-1211 (c) Copyright 2012 Physicians Postgraduate Press, Inc.
C1 [Milaneschi, Yuri; Vogelzangs, Nicole; Penninx, Brenda W. J. H.] Vrije Univ Amsterdam Med Ctr, GGZ InGeest, Dept Psychiat, NL-1081 HL Amsterdam, Netherlands.
   [Milaneschi, Yuri; Simonsick, Eleanor M.; Tolea, Magdalena I.; Ferrucci, Luigi] NIA, Longitudinal Studies Sect, Clin Res Branch, Baltimore, MD 21224 USA.
   [Harris, Tamara B.] NIA, Lab Epidemiol Demog & Biometry, Bethesda, MD 20892 USA.
   [Strotmeyer, Elsa S.] Univ Pittsburgh, Grad Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA USA.
   [Yaffe, Kristine] Univ Calif San Francisco, Dept Psychiat, San Francisco, CA USA.
C3 Vrije Universiteit Amsterdam; VU UNIVERSITY MEDICAL CENTER; National
   Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA);
   National Institutes of Health (NIH) - USA; NIH National Institute on
   Aging (NIA); Pennsylvania Commonwealth System of Higher Education
   (PCSHE); University of Pittsburgh; University of California System;
   University of California San Francisco
RP Milaneschi, Y (corresponding author), Vrije Univ Amsterdam Med Ctr, GGZ InGeest, Dept Psychiat, AJ Ernststr 1187, NL-1081 HL Amsterdam, Netherlands.
EM y.milaneschi@ggzingeest.nl
RI Strotmeyer, Elsa/F-3015-2014; Simonsick, Eleanor/W-6864-2019; Ferrucci,
   Luigi/AED-9724-2022; Yaffe, Kristine/LLL-8209-2024; Penninx,
   Brenda/S-7627-2017
OI Strotmeyer, Elsa/0000-0002-4093-6036; Milaneschi,
   Yuri/0000-0002-3697-6617; Ferrucci, Luigi/0000-0002-6273-1613
FU National Institute on Aging [N01-AG-6-2101, N01-AG-6-2103,
   N01-AG-6-2106]; Intramural Research Program of the National Institutes
   of Health-National Institute on Aging
FX The Health, Aging, and Body Composition (Health ABC) study is supported
   by the National Institute on Aging (N01-AG-6-2101, N01-AG-6-2103, and
   N01-AG-6-2106) and partly by the Intramural Research Program of the
   National Institutes of Health-National Institute on Aging.
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NR 46
TC 67
Z9 75
U1 0
U2 21
PU PHYSICIANS POSTGRADUATE PRESS
PI MEMPHIS
PA P O BOX 752870, MEMPHIS, TN 38175-2870 USA
SN 0160-6689
J9 J CLIN PSYCHIAT
JI J. Clin. Psychiatry
PD SEP
PY 2012
VL 73
IS 9
BP 1205
EP 1211
DI 10.4088/JCP.11m07552
PG 7
WC Psychology, Clinical; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA 090SN
UT WOS:000315000400005
PM 22687702
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Tancic-Gajic, M
   Vukcevic, M
   Ivovic, M
   Marina, LV
   Arizanovic, Z
   Soldatovic, I
   Stojanovic, M
   Dogo, A
   Kendereski, A
   Vujovic, S
AF Tancic-Gajic, Milina
   Vukcevic, Miodrag
   Ivovic, Miomira
   Marina, Ljiljana V.
   Arizanovic, Zorana
   Soldatovic, Ivan
   Stojanovic, Milos
   Dogo, Aleksandar
   Kendereski, Aleksandra
   Vujovic, Svetlana
TI Obstructive Sleep Apnea Is Associated With Low Testosterone Levels in
   Severely Obese Men
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Article
DE obesity; metabolic syndrome; sleep apnea; testosterone; male
ID POSITIVE AIRWAY PRESSURE; METABOLIC SYNDROME; ERECTILE DYSFUNCTION;
   OXYGEN DESATURATION; BODY-WEIGHT; HYPOXIA; DEPRESSION; ENDOCRINE;
   IMPOTENCE; EFFICACY
AB Background Disrupted sleep affects cardio-metabolic and reproductive health. Obstructive sleep apnea syndrome represents a major complication of obesity and has been associated with gonadal axis activity changes and lower serum testosterone concentration in men. However, there is no consistent opinion on the effect of obstructive sleep apnea on testosterone levels in men. Objective The aim of this study was to determine the influence of obstructive sleep apnea on total and free testosterone levels in severely obese men. Materials and methods The study included 104 severely obese (Body Mass Index (BMI) >= 35 kg/m(2)) men, aged 20 to 60, who underwent anthropometric, blood pressure, fasting plasma glucose, lipid profile, and sex hormone measurements. All participants were subjected to polysomnography. According to apnea-hypopnea index (AHI) patients were divided into 3 groups: <15 (n = 20), 15 - 29.9 (n = 17) and >= 30 (n = 67). Results There was a significant difference between AHI groups in age (29.1 +/- 7.2, 43.2 +/- 13.2, 45.2 +/- 10.2 years; p < 0.001), BMI (42.8 +/- 5.9, 43.2 +/- 5.9, 47.1 +/- 7.8 kg/m(2); p = 0.023), the prevalence of metabolic syndrome (MetS) (55%, 82.4%, 83.6%, p = 0.017), continuous metabolic syndrome score (siMS) (4.01 +/- 1.21, 3.42 +/- 0.80, 3.94 +/- 1.81, 4.20 +/- 1.07; p = 0.038), total testosterone (TT) (16.6 +/- 6.1, 15.2 +/- 5.3, 11.3 +/- 4.44 nmol/l; p < 0.001) and free testosterone (FT) levels (440.4 +/- 160.8, 389.6 +/- 162.5, 294.5 +/- 107.0 pmol/l; p < 0.001). TT level was in a significant negative correlation with AHI, oxygen desaturation index (ODI), BMI, MetS and siMS. Also, FT was in a significant negative correlation with AHI, ODI, BMI, age, MetS and siMS. The multiple regression analysis revealed that both AHI and ODI were in significant correlation with TT and FT after adjustment for age, BMI, siMS score and MetS components. Conclusion Obstructive sleep apnea is associated with low TT and FT levels in severely obese men.
C1 [Tancic-Gajic, Milina; Ivovic, Miomira; Marina, Ljiljana V.; Arizanovic, Zorana; Stojanovic, Milos; Kendereski, Aleksandra; Vujovic, Svetlana] Univ Belgrade, Fac Med, Clin Endocrinol Diabet & Metab Dis, Univ Clin Ctr Serbia,Dept Obes Reprod & Metab Dis, Belgrade, Serbia.
   [Vukcevic, Miodrag] Univ Belgrade, Dept Pulmonol, Clin Hosp Ctr Zemun, Fac Med, Belgrade, Serbia.
   [Soldatovic, Ivan] Univ Belgrade, Fac Med, Inst Med Stat & Informat, Belgrade, Serbia.
   [Dogo, Aleksandar] Clin Ctr Montenegro, Dept Endocrinol, Podgorica, Montenegro.
C3 University of Belgrade; Clinical Centre of Serbia; University of
   Belgrade; University of Belgrade
RP Marina, LV (corresponding author), Univ Belgrade, Fac Med, Clin Endocrinol Diabet & Metab Dis, Univ Clin Ctr Serbia,Dept Obes Reprod & Metab Dis, Belgrade, Serbia.
EM ljilja.marina@gmail.com
RI Ivovic, Miomira/ABE-8298-2021; Marina, Ljiljana/AAH-1185-2019
OI Marina, Ljiljana/0000-0003-2664-3664; Vukcevic,
   Miodrag/0000-0002-6218-3848; Tancic-Gajic, Milina/0000-0001-7290-5181
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NR 54
TC 5
Z9 5
U1 0
U2 5
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD JUL 26
PY 2021
VL 12
AR 622496
DI 10.3389/fendo.2021.622496
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA TX2FL
UT WOS:000682905800001
PM 34381420
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Hewlings, SJ
   Kalman, DS
AF Hewlings, Susan J.
   Kalman, Douglas S.
TI Curcumin: A Review of Its Effects on Human Health
SO FOODS
LA English
DT Review
DE curcumin; turmeric; antioxidant; anti-inflammatory; polyphenol
ID METABOLIC SYNDROME; ANTIINFLAMMATORY PROPERTIES; PIPERINE COMBINATION;
   KNEE OSTEOARTHRITIS; OBESE INDIVIDUALS; DELIVERY-SYSTEM; MUSCLE DAMAGE;
   DOUBLE-BLIND; ANTIOXIDANT; EFFICACY
AB Turmeric, a spice that has long been recognized for its medicinal properties, has received interest from both the medical/scientific world and from culinary enthusiasts, as it is the major source of the polyphenol curcumin. It aids in the management of oxidative and inflammatory conditions, metabolic syndrome, arthritis, anxiety, and hyperlipidemia. It may also help in the management of exercise-induced inflammation and muscle soreness, thus enhancing recovery and performance in active people. In addition, a relatively low dose of the complex can provide health benefits for people that do not have diagnosed health conditions. Most of these benefits can be attributed to its antioxidant and anti-inflammatory effects. Ingesting curcumin by itself does not lead to the associated health benefits due to its poor bioavailability, which appears to be primarily due to poor absorption, rapid metabolism, and rapid elimination. There are several components that can increase bioavailability. For example, piperine is the major active component of black pepper and, when combined in a complex with curcumin, has been shown to increase bioavailability by 2000%. Curcumin combined with enhancing agents provides multiple health benefits. The purpose of this review is to provide a brief overview of the plethora of research regarding the health benefits of curcumin.
C1 [Hewlings, Susan J.] Cent Michigan Univ, Dept Nutr, Mt Pleasant, MI 48859 USA.
   [Hewlings, Susan J.] Substantiat Sci, Weston, FL 33332 USA.
   [Kalman, Douglas S.] Nova Southeastern Univ, Hlth & Human Performance, Ft Lauderdale, FL 33314 USA.
   [Kalman, Douglas S.] QPS, Nutr Res Div, Miami, FL 33143 USA.
C3 Central Michigan University; Nova Southeastern University
RP Hewlings, SJ (corresponding author), Cent Michigan Univ, Dept Nutr, Mt Pleasant, MI 48859 USA.; Hewlings, SJ (corresponding author), Substantiat Sci, Weston, FL 33332 USA.
EM sue.hewlings@gmail.com; dougkalman@gmail.com
OI Hewlings, Susan/0000-0001-8540-2591
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NR 66
TC 1610
Z9 1699
U1 36
U2 331
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2304-8158
J9 FOODS
JI Foods
PD OCT
PY 2017
VL 6
IS 10
AR 92
DI 10.3390/foods6100092
PG 11
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA FL9PZ
UT WOS:000414590300009
PM 29065496
OA Green Published, gold, Green Submitted
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Li, SP
   Zeng, XY
   Zhou, X
   Wang, H
   Ja, EJ
   Robinson, SR
   Xu, AM
   Ye, JM
AF Li, Songpei
   Zeng, Xiao-Yi
   Zhou, Xiu
   Wang, Hao
   Ja, Eunjung
   Robinson, Stephen R.
   Xu, Aimin
   Ye, Ji-Ming
TI Dietary cholesterol induces hepatic inflammation and blunts
   mitochondrial function in the liver of high-fat-fed mice
SO JOURNAL OF NUTRITIONAL BIOCHEMISTRY
LA English
DT Article
DE Dietary cholesterol; High fat diet; Inflammation; Mitochondrial
   function; Nonalcoholic fatty liver disease
ID INDUCED INSULIN-RESISTANCE; NONALCOHOLIC-STEATOHEPATITIS; OXIDATIVE
   STRESS; DIABETIC-RETINOPATHY; METABOLIC SYNDROME; SKELETAL-MUSCLE;
   PROTEIN-KINASE; FED RATS; DISEASE; OBESITY
AB The present study investigated the role of dietary cholesterol and fat in the development of nonalcoholic fatty liver disease, a common liver disease in metabolic disorders. Mice were fed a diet of regular chow (CH), chow supplemented with 0.2% w/w cholesterol (CHC), high fat (HF, 45 kcal%) or HF with cholesterol (HFC) for 17 weeks. While both HF and HFC groups displayed hepatic steatosis and metabolic syndrome, only HFC group developed the phenotype of liver injury, as indicated by an increase in plasma level of alanine transaminase (ALT, by 50-80%). There were similar to 2-fold increases in mRNA expression of tumor necrosis factor et, interleukin 113 and monocyte chemotactic protein 1 in the liver of HFC-fed mice (vs. HF) but no endoplasmic reticulum stress or oxidative stress was observed. Furthermore, cholesterol suppressed HF-induced increase of peroxisome proliferator-activated receptor gamma coactivator lot and mitochondrial transcription factor A expression and blunted fatty acid oxidation. Interestingly, after switching HFC to HF diet for 5 weeks, the increases in plasma ALT and liver inflammatory markers were abolished but the blunted of mitochondrial function remained. These findings suggest that cholesterol plays a critical role in the conversion of a simple fatty liver toward nonalcoholic steatohepatitis possibly by activation of inflammatory pathways together with retarded mitochondria( function. (C) 2015 Elsevier Inc. All rights reserved.
C1 [Li, Songpei; Zeng, Xiao-Yi; Zhou, Xiu; Wang, Hao; Ja, Eunjung; Robinson, Stephen R.; Ye, Ji-Ming] RMIT Univ, Hlth Innovat Res Inst, Melbourne, Vic 3083, Australia.
   [Li, Songpei; Zeng, Xiao-Yi; Zhou, Xiu; Wang, Hao; Ja, Eunjung; Robinson, Stephen R.; Ye, Ji-Ming] RMIT Univ, Sch Hlth Sci, Melbourne, Vic 3083, Australia.
   [Xu, Aimin] Univ Hong Kong, State Key Lab Pharmaceut Biotechnol, Hong Kong, Hong Kong, Peoples R China.
   [Xu, Aimin] Univ Hong Kong, Dept Med, Hong Kong, Hong Kong, Peoples R China.
C3 Royal Melbourne Institute of Technology (RMIT); Royal Melbourne
   Institute of Technology (RMIT); University of Hong Kong; University of
   Hong Kong
RP Ye, JM (corresponding author), RMIT Univ, Lipid Biol & Metab Dis, Hlth Innovat Res Inst, Bldg 202,Level 4,POB 71, Melbourne, Vic 3083, Australia.
EM jiming.ye@rmit.edu.au
RI Robinson, Stephen/AAU-3219-2021; xu, aimin/K-4332-2019; ZHOU,
   XIU/AAX-5312-2020; Wang, Hao/AFK-7816-2022
OI Wang, Hao/0000-0002-0901-5183; Robinson, Stephen/0000-0002-0987-0075
FU National Health and Medical Research Council of Australia [535921]
FX The authors would like to acknowledge Dr. Suzanne Rogers (RMIT
   University) for her critique of this manuscript. This study was
   supported by the National Health and Medical Research Council of
   Australia Program Grant 535921 (allocation to JMY).
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NR 57
TC 26
Z9 26
U1 1
U2 23
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0955-2863
EI 1873-4847
J9 J NUTR BIOCHEM
JI J. Nutr. Biochem.
PD JAN
PY 2016
VL 27
BP 96
EP 103
DI 10.1016/j.jnutbio.2015.08.021
PG 8
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA CZ9HX
UT WOS:000367409800011
PM 26391864
DA 2025-06-11
ER

PT J
AU Selenius, JS
   Wasenius, NS
   Kautiainen, H
   Salonen, M
   von Bonsdorff, M
   Eriksson, JG
AF Selenius, Jannica S.
   Wasenius, Niko S.
   Kautiainen, Hannu
   Salonen, Minna
   von Bonsdorff, Mikaela
   Eriksson, Johan G.
TI Impaired glucose regulation, depressive symptoms, and health-related
   quality of life
SO BMJ OPEN DIABETES RESEARCH & CARE
LA English
DT Article
ID METABOLIC SYNDROME; DIABETES-MELLITUS; PSYCHOMETRIC PROPERTIES;
   INVENTORY-II; POPULATION; PREVALENCE; RISK; COMPLICATIONS; ASSOCIATION
AB Introduction This study aims to investigate whether the associations between impaired glucose regulation and health-related quality of life are modified by severity or type of depressive symptoms.
   Research design and methods For this cross-sectional study, we included 1939 individuals (mean age 61.5 years) from the Helsinki Birth Cohort Study. Between 2001 and 2004, a standard 2-hour 75 g oral glucose tolerance test was applied to define normoglycemia, pre-diabetes, and newly diagnosed diabetes. Information on previously diagnosed diabetes was collected from national registers and questionnaires. Pre-diabetes was defined as having either impaired fasting glucose or impaired glucose tolerance. The Mental and Physical Component Scores of health-related quality of life were assessed with Short Form-36. Beck's Depression Inventory was employed to investigate the severity of depressive symptoms and to define minimal (depression score <10), non-melancholic, and melancholic types of depression. We analyzed data with general linear models adjusted for sex, age, lifestyle factors, comorbidities, and body mass index.
   Results Glucose regulation subgroups, especially previously known diabetes, were associated with lower Physical Component Score (p=0.001) and higher depression score (p=0.015), but not with the Mental Component Score (p=0.189). Non-melancholic depression was associated with lower Physical and Mental Component Scores compared with those with depression score <10 and melancholic depression (p<0.001), independently of glucose regulation status (p for glucose regulation status by depression type interaction >0.54).
   Conclusions Non-melancholic type of depression and previously known diabetes are independently associated with lower health-related quality of life. This should be appraised in long-term treatment of diabetes and when treating non-melancholic depressive symptoms to maintain a higher health-related quality of life.
C1 [Selenius, Jannica S.; Wasenius, Niko S.; Kautiainen, Hannu; Eriksson, Johan G.] Univ Helsinki, Dept Gen Practice & Primary Hlth Care, Helsinki, Finland.
   [Selenius, Jannica S.; Wasenius, Niko S.; Salonen, Minna; von Bonsdorff, Mikaela; Eriksson, Johan G.] Folkhalsan Res Ctr, Publ Hlth Res Porgramme, Helsinki, Finland.
   [Salonen, Minna] Natl Publ Hlth Inst, Dept Epidemiol & Hlth Promot, Helsinki, Finland.
   [von Bonsdorff, Mikaela] Univ Jyvaskyla, Gerontol Res Ctr, Jyvaskyla, Finland.
   [von Bonsdorff, Mikaela] Univ Jyvaskyla, Fac Sport & Hlth Sci, Jyvaskyla, Finland.
   [Eriksson, Johan G.] ASTAR, Singapore Inst Clin Sci SICS, Singapore, Singapore.
   [Eriksson, Johan G.] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Obstet & Gynecol, Singapore, Singapore.
C3 University of Helsinki; Folkhalsan Research Center; Finland National
   Institute for Health & Welfare; University of Jyvaskyla; University of
   Jyvaskyla; Agency for Science Technology & Research (A*STAR); A*STAR -
   Singapore Institute for Clinical Sciences (SICS); National University of
   Singapore
RP Selenius, JS (corresponding author), Univ Helsinki, Dept Gen Practice & Primary Hlth Care, Helsinki, Finland.; Selenius, JS (corresponding author), Folkhalsan Res Ctr, Publ Hlth Res Porgramme, Helsinki, Finland.
EM jannica.selenius@helsinki.fi
RI Gibbs, J. Raphael/A-3984-2010; Wasenius, Niko/AAE-8927-2020; von
   Bonsdorff, Mikaela/A-5218-2015
OI Wasenius, Niko/0000-0002-9007-6660; Eriksson, Johan/0000-0002-2516-2060;
   Selenius, Jannica/0000-0002-4336-8580; von Bonsdorff,
   Mikaela/0000-0001-8530-5230
FU Finnish Foundation for Cardiovascular Research; Finnish Foundation for
   Diabetes Research; Juho Vainio Foundation; Academy of Finland; Novo
   Nordisk Foundation; Signe and Ane Gyllenberg Foundation; Samfundet
   Folkhalsan; Finska Lakaresallskapet; Liv och Halsa; European Commission
   FP7 (DORIAN) [278 603]; EU H2020-PHC2014-DynaHealth [633 595]; EU
   Horizon 2020 Award [733 206 LIFECYCLE]
FX HBCS was supported by Finnish Foundation for Cardiovascular Research,
   Finnish Foundation for Diabetes Research, Juho Vainio Foundation,
   Academy of Finland, Novo Nordisk Foundation, Signe and Ane Gyllenberg
   Foundation, Samfundet Folkhalsan, Finska Lakaresallskapet, Liv och
   Halsa, European Commission FP7 (DORIAN) Grant Agreement No 278 603 and
   EU H2020-PHC2014-DynaHealth Grant No 633 595 and EU Horizon 2020 Award
   733 206 LIFECYCLE.
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   World Health Organization, 2006, DEF DIAGN DIAB MELL
NR 42
TC 8
Z9 8
U1 0
U2 3
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
EI 2052-4897
J9 BMJ OPEN DIAB RES CA
JI BMJ Open Diab. Res. Care
PY 2020
VL 8
IS 1
AR e001568
DI 10.1136/bmjdrc-2020-001568
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism
GA OL2XJ
UT WOS:000585205100004
PM 33077474
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Chan, RNC
   Huang, CG
   Ng, NYH
   Tam, HCH
   Tam, CHT
   Cheng, FF
   Wong, KK
   Shi, M
   Ng, ACW
   Tsang, AYT
   Wang, CC
   Cheung, LP
   Tam, WH
   Joglekar, MV
   Hardikar, AA
   Jenkins, AJ
   Chan, JCN
   Lim, CKP
   Ma, RCW
AF Chan, Raymond N. C.
   Huang, Chuiguo
   Ng, Noel Y. H.
   Tam, Henry C. H.
   Tam, Claudia H. T.
   Cheng, Feifei
   Wong, Kwun Kiu
   Shi, Mai
   Ng, Alex C. W.
   Tsang, Atta Y. T.
   Wang, Chi Chiu
   Cheung, Lai Ping
   Tam, Wing Hung
   Joglekar, Mugdha V.
   Hardikar, Anandwardhan A.
   Jenkins, Alicia J.
   Chan, Juliana C. N.
   Lim, Cadmon K. P.
   Ma, Ronald C. W.
TI Shortened Relative Leukocyte Telomere Length Is Associated With
   Polycystic Ovary Syndrome and Metabolic Traits
SO ENDOCRINOLOGY DIABETES & METABOLISM
LA English
DT Article
DE dysglycemia; dyslipidemia; leukocyte telomere length; polycystic ovary
   syndrome
ID OXIDATIVE STRESS; CARDIOMETABOLIC RISK; INSULIN-RESISTANCE; CHINESE
   WOMEN; SYNDROME PCOS; PROGRESSION; PREVALENCE; DISEASE
AB Background: Polycystic ovary syndrome (PCOS) is one of the commonest gyneco-endocrine disorders amongst women of reproductive age. Whether PCOS and cardiometabolic traits in PCOS patients are associated with shortened telomere length (TL) or relative leukocyte telomere length (rLTL) remains unclear. Methods: 214 women with PCOS and 214 age-matched women were recruited. rLTL was measured with an updated quantitative real-time PCR protocol and reported as Delta Delta Ct between telomere and a single-copy gene encoding beta-globin relative to a normalisation control. A two-way Mendelian randomization analysis using the UK Biobank Resource was performed to assess the causal relationship between rLTL and PCOS. Results: Women with PCOS had significantly shortened rLTL (PCOS: 0.5 +/- 0.7; control: 0.8 +/- 0.6; p < 0.001). Longer rLTL was associated with a lower risk of PCOS after adjusting for age, history of smoking and other cardiometabolic traits (OR: 0.503; 95% CI: 0.342-0.730; p < 0.001). Longer rLTL was associated with reduced risk of dyslidpidemia (OR: 0.563; 95% CI: 0.450-0.968; p = 0.042) in PCOS patients. PCOS subjects with rLTL shorter than mean of the rLTL of control subjects had an elevated risk of dysglycemia (OR: 2.09; 95% CI: 1.04-4.29; p = 0.040). No causal relationships were found between rLTL and PCOS in the Mendelian randomization study. Conclusions: Women with PCOS have significantly reduced rLTL and shorter LTL may be associated with cardiometabolic risk factors in PCOS subjects. There are no causal relationship between genetically determined PCOS and TL or vice versa.
C1 [Chan, Raymond N. C.; Huang, Chuiguo; Ng, Noel Y. H.; Tam, Henry C. H.; Tam, Claudia H. T.; Cheng, Feifei; Wong, Kwun Kiu; Shi, Mai; Ng, Alex C. W.; Tsang, Atta Y. T.; Jenkins, Alicia J.; Chan, Juliana C. N.; Lim, Cadmon K. P.; Ma, Ronald C. W.] Chinese Univ Hong Kong, Prince Wales Hosp, Dept Med & Therapeut, Hong Kong, Peoples R China.
   [Wang, Chi Chiu; Cheung, Lai Ping; Tam, Wing Hung] Chinese Univ Hong Kong, Prince Wales Hosp, Dept Obstet & Gynaecol, Hong Kong, Peoples R China.
   [Wang, Chi Chiu; Chan, Juliana C. N.; Lim, Cadmon K. P.; Ma, Ronald C. W.] Chinese Univ Hong Kong, Li Ka Shing Inst Hlth Sci, Hong Kong, Peoples R China.
   [Joglekar, Mugdha V.; Hardikar, Anandwardhan A.] Western Sydney Univ, Sch Med, Diabet & Islet Biol Grp, Sydney, NSW, Australia.
   [Jenkins, Alicia J.] Baker Heart & Diabet Inst, Melbourne, Vic, Australia.
   [Jenkins, Alicia J.] Univ Sydney, Fac Med & Hlth, NHMRC Clin Trial Ctr, Sydney, NSW, Australia.
   [Chan, Juliana C. N.; Ma, Ronald C. W.] Chinese Univ Hong Kong, Hong Kong Inst Diabet & Obes, Hong Kong, Peoples R China.
   [Chan, Juliana C. N.; Ma, Ronald C. W.] Chinese Univ Hong Kong, Shanghai Jiao Tong Univ Joint Res Ctr Diabet Genom, Hong Kong, Peoples R China.
C3 Chinese University of Hong Kong; Prince of Wales Hospital; Chinese
   University of Hong Kong; Prince of Wales Hospital; Chinese University of
   Hong Kong; Western Sydney University; Baker Heart and Diabetes
   Institute; University of Sydney; Chinese University of Hong Kong;
   Chinese University of Hong Kong
RP Ma, RCW (corresponding author), Chinese Univ Hong Kong, Prince Wales Hosp, Dept Med & Therapeut, Hong Kong, Peoples R China.; Ma, RCW (corresponding author), Chinese Univ Hong Kong, Li Ka Shing Inst Hlth Sci, Hong Kong, Peoples R China.; Ma, RCW (corresponding author), Chinese Univ Hong Kong, Hong Kong Inst Diabet & Obes, Hong Kong, Peoples R China.; Ma, RCW (corresponding author), Chinese Univ Hong Kong, Shanghai Jiao Tong Univ Joint Res Ctr Diabet Genom, Hong Kong, Peoples R China.
EM rcwma@cuhk.edu.hk
RI Wang, Ronald/C-6541-2014; Joglekar, Mugdha/AFP-0659-2022; chuiguo,
   huang/ADV-5549-2022; Tam, Hung/AAE-3628-2020; Chan, Raymond Ngai
   Chiu/GPC-8320-2022; Ma, Ronald/C-2788-2009
OI Ma, Ronald/0000-0002-1227-803X; Chan, Raymond Ngai
   Chiu/0000-0002-1678-9128
FU University Grants Committee Research Grants Matching Scheme; Chinese
   University of Hong Kong Direct Grant; Research Grants Council Research
   Impact Fund [R4012-18]; Croucher Foundation Senior Medical Research
   Fellowship; RGC General Research Fund [14110415, 14102719, CUHK473408,
   CUHK471713]
FX This project was supported by a Chinese University of Hong Kong Direct
   Grant and the University Grants Committee Research Grants Matching
   Scheme. RCWM acknowledge partial support from the Research Grants
   Council Research Impact Fund (R4012-18), and a Croucher Foundation
   Senior Medical Research Fellowship. The recruitment and follow-up of
   PCOS subjects and control subjects were previously supported by the RGC
   General Research Fund (ref. 14110415, 14102719, CUHK473408 and
   CUHK471713). The authors acknowledge Dr. Andrzej Januszewski and Dr.
   Luke Carroll (University of Sydney) for providing assistance for the DNA
   QC material.
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NR 47
TC 0
Z9 0
U1 1
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
EI 2398-9238
J9 ENDOCRIN DIAB METAB
JI Endocrinol. Diabetes Metab.
PD MAR
PY 2025
VL 8
IS 2
AR e70030
DI 10.1002/edm2.70030
PG 12
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA X3F1Y
UT WOS:001424241400001
PM 39963020
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Emiliano, AF
   de Cavalho, LCRM
   Cordeiro, VDC
   da Costa, CA
   de Oliveira, PBR
   Queiroz, EF
   Moreira, DD
   Boaventura, GT
   de Moura, RS
   Resende, AC
AF Emiliano, Andrea Fernandes
   Reis Marins de Cavalho, Lenize Costa
   Cristino Cordeiro, Viviane da Silva
   da Costa, Cristiane Aguiar
   Raquel de Oliveira, Paola Braz
   Queiroz, Emerson Ferreira
   Moreira, Daniele Dal Col
   Boaventura, Gilson Teles
   de Moura, Roberto Soares
   Resende, Angela Castro
TI Metabolic Disorders and Oxidative Stress Programming in Offspring of
   Rats Fed a High-fat Diet During Lactation: Effects of a Vinifera
   Grape Skin (ACH09) Extract
SO JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
LA English
DT Article
DE grape skin extract; hypertension; insulin resistance; oxidative stress;
   developmental programming
ID SPONTANEOUSLY HYPERTENSIVE-RATS; INSULIN-RESISTANCE; INDUCED OBESITY;
   BLOOD-PRESSURE; NITRIC-OXIDE; RICH DIET; ANTIOXIDANTS; MECHANISM;
   ANTHOCYANINS; VASODILATION
AB This study examined the effect of Vitis vinifera grape skin ACH09 extract (ACH09) on metabolic disorders and oxidative stress in adult offspring of rats fed a high-fat diet (HF) during lactation. Four groups of female rats were fed: control diet (7% fat); ACH09 (7% fat + 200 mg.kg(-1.)d(-1) ACH09 orally); HF (24% fat); HF+ ACH09 (24% fat + 200 mg.kg(-1.)d(-1) ACH09 orally) during lactation. From weaning onward, all female offspring were fed a control diet and killed when they were 90 or 180 days old. Systolic blood pressure was increased in adult offspring of HF-fed dams, and ACH09 prevented hypertension. Increased adiposity, plasma triglyceride, glucose levels, and insulin resistance were observed in offspring from both ages, and these changes were reversed by ACH09. The plasma oxidative damage assessed by malondialdehyde levels was increased, and nitrite levels decreased in the HF group of both ages, which were reversed by ACH09. In addition, ACH09 restored the decreased plasma and mesenteric artery antioxidant activities of superoxide dismutase, catalase, and glutathione peroxidase in the HF group. In conclusion, ACH09 protected normally fed offspring of HF-fed dams during lactation from phenotypic and metabolic characteristics of metabolic syndrome providing an alternative nutritional resource for the prevention of metabolic syndrome.
C1 [Emiliano, Andrea Fernandes; Reis Marins de Cavalho, Lenize Costa; Cristino Cordeiro, Viviane da Silva; da Costa, Cristiane Aguiar; Raquel de Oliveira, Paola Braz; de Moura, Roberto Soares; Resende, Angela Castro] Univ Estado Rio De Janeiro, Dept Pharmacol, Inst Biol, Rio De Janeiro, RJ, Brazil.
   [Queiroz, Emerson Ferreira; Moreira, Daniele Dal Col] Ache Labs SA, Dept Res Dev & Innovat, Guarulhos, Brazil.
   [Boaventura, Gilson Teles] Univ Fed Fluminense, Dept Expt Nutr, BR-24220000 Niteroi, RJ, Brazil.
C3 Universidade do Estado do Rio de Janeiro; Universidade Federal
   Fluminense
RP Resende, AC (corresponding author), Univ Estado Rio de Janeiro, Dept Farmacol & Psicobiol, Inst Biol, Av 28 Setembro,87, BR-20551030 Rio De Janeiro, Brazil.
EM angelacr@uerj.br
RI Resende, Angela/M-8632-2017; Costa, Cristiane/AAF-8475-2021; Queiroz,
   Emerson/AAU-6235-2020; Boaventura, Gilson/D-6317-2014
OI Aguiar da Costa, Cristiane/0000-0003-1927-1794; Boaventura, Gilson
   Teles/0000-0001-8376-330X; Ferreira Queiroz, Emerson/0000-0001-9567-1664
FU National Council of Scientific and Technological Development (CNPq); Rio
   de Janeiro State Research Agency (FAPERJ)
FX Supported by grants from the National Council of Scientific and
   Technological Development (CNPq) and Rio de Janeiro State Research
   Agency (FAPERJ).
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NR 55
TC 22
Z9 22
U1 0
U2 8
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0160-2446
EI 1533-4023
J9 J CARDIOVASC PHARM
JI J. Cardiovasc. Pharmacol.
PD SEP
PY 2011
VL 58
IS 3
BP 319
EP 328
DI 10.1097/FJC.0b013e3182244a51
PG 10
WC Cardiac & Cardiovascular Systems; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Pharmacology & Pharmacy
GA 816KW
UT WOS:000294599400011
PM 21697730
DA 2025-06-11
ER

PT J
AU Bain, J
AF Bain, Jerald
TI Testosterone and the aging male: To treat or not to treat?
SO MATURITAS
LA English
DT Review
DE Aging male; Testosterone; Hypogonadism; Cardiovascular disease; Prostate
   cancer; Metabolic syndrome
ID ANDROGEN-DEPRIVATION THERAPY; CLINICAL-RESEARCH CENTER; LEAN BODY-MASS;
   PROSTATE-CANCER; OLDER MEN; REPLACEMENT THERAPY; METABOLIC SYNDROME;
   HYPOGONADAL MEN; INSULIN-RESISTANCE; ELDERLY-MEN
AB It is well-established that total testosterone (TT) in men decreases with age and that bioavailable testosterone (bio-T) falls to an even greater extent. The clinical relevance of declining androgens in the aging male and use of testosterone replacement therapy (TRT) in this situation is controversial. Most studies have been short term and there are no large randomized placebo-controlled trials. Testosterone has many physiological actions in: muscles, bones, hematopoietic system, brain, reproductive and sexual organs, adipose tissue. Within these areas it stimulates: muscle growth and maintenance, bone development while inhibiting bone resorption, the production of red blood cells to increase hemoglobin, libido, enhanced mood and cognition, erectile function and lipolysis. Anabolic deficits in aging men can induce: frailty, sarcopenia, poor muscle quality, muscle weakness, hypertrophy of adipose tissue and impaired neurotransmission. The aging male with reduced testosterone availability may present with a wide variety of symptoms which in addition to frailty and weakness include: fatigue, decreased energy, decreased motivation, cognitive impairment, decreased self-confidence, depression, irritability, osteoporotic pain and the lethargy of anemia. In addition, testosterone deficiency is also associated with type-2 diabetes, the metabolic syndrome, coronary artery disease, stroke and transient ischemic attacks, and cardiovascular disease in general. Furthermore, there are early studies to suggest that TRT in men with low testosterone levels may improve metabolic status by: lowering blood sugar and HbA1C in men with type-2 diabetes, reducing abdominal girth, ameliorating features of the metabolic syndrome, all of which may be protective of the cardiovascular system. The major safety issue is prostate cancer but there is no evidence that supports the idea that testosterone causes the development of a de novo cancer. So on balance in a man with symptoms of hygonadism and low or lowish levels of testosterone with no evidence of prostate cancer such as a normal PSA a therapeutic (4-6 months) trial of TRT is justified. Treatment and monitoring of this duration will determine whether the patient is responsive. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
C1 [Bain, Jerald] Mt Sinai Hosp, Div Endocrinol & Metab, Toronto, ON M5G 1X5, Canada.
   [Bain, Jerald] Univ Toronto, Dept Med, Toronto, ON M5S 1A1, Canada.
   [Bain, Jerald] Univ Toronto, Dept Obstet & Gynecol, Toronto, ON M5S 1A1, Canada.
C3 University of Toronto; Sinai Health System Toronto; Lunenfeld Tanenbaum
   Research Institute; University of Toronto; University of Toronto
RP Bain, J (corresponding author), Mt Sinai Hosp, Div Endocrinol & Metab, Suite 1501,600 Univ Ave, Toronto, ON M5G 1X5, Canada.
EM j.bain@utoronto.ca
FU former Organon Canada; Solvay Pharma; Schering-Plough and Paladin Labs
   Inc
FX The author has given lectures sponsored by the former Organon Canada and
   Solvay Pharma and has served on advisory boards of these companies. He
   has also given lectures sponsored by Schering-Plough and Paladin Labs
   Inc.
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NR 74
TC 62
Z9 71
U1 0
U2 18
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0378-5122
EI 1873-4111
J9 MATURITAS
JI Maturitas
PD MAY
PY 2010
VL 66
IS 1
BP 16
EP 22
DI 10.1016/j.maturitas.2010.01.009
PG 7
WC Geriatrics & Gerontology; Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology; Obstetrics & Gynecology
GA 599ZN
UT WOS:000277953200004
PM 20153946
DA 2025-06-11
ER

PT J
AU Victoria-Montesinos, D
   Ballester, P
   Barcina-Pérez, P
   García-Muñoz, AM
AF Victoria-Montesinos, Desiree
   Ballester, Pura
   Barcina-Perez, Pablo
   Garcia-Munoz, Ana Maria
TI Systematic Review and Meta-Analysis of Sclerocarya birrea on
   Metabolic Disorders: Evidence from Preclinical Studies
SO METABOLITES
LA English
DT Article
DE Sclerocarya birrea; metabolic disorders;
   antihyperglycemic; cardiometabolic risk; nutraceuticals; polyphenols
ID BETA-CELL DYSFUNCTION; BARK AQUEOUS EXTRACT; INSULIN-RESISTANCE;
   GLUCOSE-TOLERANCE; NITRIC-OXIDE; ALPHA; PATHOGENESIS; AMYLASE; HOCHST;
   RISK
AB Background/Objectives: Metabolic disorders, including diabetes, obesity, and cardiovascular diseases, are significant global health issues. Nutraceuticals, such as Sclerocarya birrea (SB), known for its high polyphenol content, are increasingly explored for managing these conditions. This study aims to evaluate the antihyperglycemic, hypolipidemic, and antihypertensive effects of SB in animal models to understand its potential as a natural intervention for metabolic diseases. Methods: A systematic review and meta-analysis were conducted according to PRISMA guidelines. Searches across databases like PubMed, Web of Science, Embase, and Scopus identified studies using SB in animal models of metabolic disorders. Inclusion criteria were studies with SB intervention, control groups, and quantitative measures of metabolic parameters. The study was registered with INPLASY (INPLASY2024100031). Results: The meta-analysis revealed that SB significantly reduces blood glucose levels in diabetic animal models. Acute administration of SB showed a pooled standardized mean difference (SMD) of -7.13 (95% CI: -11.44 to -2.83) at 1 h and -9.75 (95% CI: -15.92 to -3.59) at 2-4 h post-administration. Chronic administration indicated a non-significant reduction in glucose levels (SMD: -5.69, 95% CI: -16.38 to 5.01). Conclusions: SB appears to have the potential for reducing blood glucose levels and may offer benefits for other cardiometabolic risk factors, including lipid profiles and oxidative stress. However, variability in the results underscores the need for further research, including standardized animal studies and clinical trials, to confirm these effects and clarify the mechanisms by which SB may impact metabolic disorders.
C1 [Victoria-Montesinos, Desiree; Ballester, Pura; Barcina-Perez, Pablo; Garcia-Munoz, Ana Maria] UCAM Univ Catolica Murcia, Fac Pharm & Nutr, Murcia 30107, Spain.
C3 Universidad Catolica de Murcia
RP Ballester, P (corresponding author), UCAM Univ Catolica Murcia, Fac Pharm & Nutr, Murcia 30107, Spain.
EM dvictoria@ucam.edu; pballester@ucam.edu; pbarcina@ucam.edu;
   amgarcia13@ucam.edu
RI Ballester, Pura/AAD-2635-2022; Victoria-Montesinos, Desirée/S-2566-2018;
   García Muñoz, Ana María/AAU-9143-2020
OI Garcia-Munoz/0000-0002-1021-5385; Ballester, Pura/0000-0002-7345-448X;
   Victoria-Montesinos, Desiree/0000-0003-3968-9477
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NR 78
TC 0
Z9 0
U1 0
U2 0
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2218-1989
J9 METABOLITES
JI Metabolites
PD NOV
PY 2024
VL 14
IS 11
AR 615
DI 10.3390/metabo14110615
PG 24
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA N6O5I
UT WOS:001365509800001
PM 39590851
OA gold
DA 2025-06-11
ER

PT J
AU Petersson, H
   Risérus, U
   McMonagle, J
   Gulseth, HL
   Tierney, AC
   Morange, S
   Helal, O
   Shaw, DI
   Ruano, JA
   López-Miranda, J
   Kiec-Wilk, B
   Golabek, I
   Blaak, EE
   Saris, WHM
   Drevon, CA
   Lovegrove, JA
   Roche, HM
   Basu, S
AF Petersson, Helena
   Riserus, Ulf
   McMonagle, Jolene
   Gulseth, Hanne L.
   Tierney, Audrey C.
   Morange, Sophie
   Helal, Olfa
   Shaw, Danielle I.
   Ruano, Juan A.
   Lopez-Miranda, Jose
   Kiec-Wilk, Beata
   Golabek, Iwona
   Blaak, Ellen E.
   Saris, Wim H. M.
   Drevon, Christian A.
   Lovegrove, Julie A.
   Roche, Helen M.
   Basu, Samar
TI Effects of dietary fat modification on oxidative stress and inflammatory
   markers in the LIPGENE study
SO BRITISH JOURNAL OF NUTRITION
LA English
DT Article
DE Dietary fat; Oxidative stress; Inflammation; Metabolic syndrome; LIPGENE
   study
ID CATALYZED LIPID-PEROXIDATION; ACID; HUMANS; PROSTAGLANDIN-F2-ALPHA;
   RADIOIMMUNOASSAY; F-2-ISOPROSTANES; ASSOCIATION; BIOMARKERS; PRODUCTS;
   F2-ALPHA
AB Subjects with the metabolic syndrome (MetS) have enhanced oxidative stress and inflammation. Dietary fat quality has been proposed to be implicated in these conditions. We investigated the impact of four diets distinct in fat quantity and quality on 8-iso-PGF(2 alpha) (a major F(2)-isoprostane and oxidative stress indicator), 15-keto-13,14-dihydro-PGF(2 alpha) (15-keto-dihydro-PGF(2 alpha), a major PGF(2 alpha) metabolite and marker of cyclooxygenase-mediated inflammation) and C-reactive protein (CRP). In a 12-week parallel multicentre dietary intervention study (LIPGENE), 417 volunteers with the MetS were randomly assigned to one of the four diets: two high-fat diets (38% energy (% E)) rich in SFA or MUFA and two low-fat high-complex carbohydrate diets (28 % E) with (LFHCC n-3) or without (LFHCC) 1.24 g/d of very long chain n-3 fatty acid supplementation. Urinary levels of 8-iso-PGF(2 alpha) and 15-keto-dihydro-PGF(2 alpha) were determined by RIA and adjusted for urinary creatinine levels. Serum concentration of CRP was measured by ELISA. Neither concentrations of 8-iso-PGF(2 alpha) and 15-keto-dihydro-PGF(2 alpha) nor those of CRP differed between diet groups at baseline (P>0.07) or at the end of the study (P>0.44). Also, no differences in changes of the markers were observed between the diet groups (8-iso-PGF(2 alpha), P=0.83; 15-keto-dihydro-PGF(2 alpha), P=0.45; and CRP, P=0.97). In conclusion, a 12-week dietary fat modification did not affect the investigated markers of oxidative stress and inflammation among subjects with the MetS in the LIPGENE study.
C1 [Petersson, Helena; Riserus, Ulf; Basu, Samar] Uppsala Univ, Dept Publ Hlth & Caring Sci Clin Nutr & Metab, S-75185 Uppsala, Sweden.
   [McMonagle, Jolene; Tierney, Audrey C.; Roche, Helen M.] Univ Coll Dublin, Sch Publ Hlth & Populat Sci, UCD Conway Inst, Nutrigenom Res Grp, Dublin 4, Ireland.
   [Gulseth, Hanne L.] Univ Oslo, Oslo Univ Hosp Aker, Dept Endocrinol, Hormone Lab, Oslo, Norway.
   [Gulseth, Hanne L.; Drevon, Christian A.] Univ Oslo, Fac Med, Inst Basic Med Sci, Dept Nutr, Oslo, Norway.
   [Morange, Sophie] Aix Marseille Univ, Hop Concept, APH M, Ctr Invest Clin, Marseille, France.
   [Helal, Olfa] INSERM, Nutr Humaine & Lipides U476, F-13385 Marseille, France.
   [Helal, Olfa] INRA, Nutriments Lipid & Prevent Malad Metab UMR1260, F-13385 Marseille, France.
   [Helal, Olfa] Univ Aix Marseille 2, Fac Med, F-13385 Marseille, France.
   [Shaw, Danielle I.; Lovegrove, Julie A.] Univ Reading, Dept Food & Nutr Sci, Reading, Berks, England.
   [Ruano, Juan A.; Lopez-Miranda, Jose] Univ Cordoba, Lipids & Atherosclerosis Res Unit, Reina Sofia Univ Hosp,Inst Salud Carlos III, Maimonides Inst Biomed Res Cordoba IMIBIC, Cordoba, Spain.
   [Golabek, Iwona] Jagiellonian Univ, Coll Med, Dept Clin Biochem, Krakow, Poland.
   [Blaak, Ellen E.; Saris, Wim H. M.] Maastricht Univ, Sch Metab Toxicol & Nutr, NUTRIM, Dept Human Biol, Maastricht, Netherlands.
   [Lovegrove, Julie A.] Univ Reading, ICMR, Reading, Berks, England.
C3 Uppsala University; University College Dublin; University of Oslo;
   University of Oslo; Institut National de la Sante et de la Recherche
   Medicale (Inserm); Aix-Marseille Universite; Assistance
   Publique-Hopitaux de Marseille; Institut National de la Sante et de la
   Recherche Medicale (Inserm); INRAE; Aix-Marseille Universite; University
   of Reading; Hospital Universitario Reina Sofia - Cordoba; Instituto de
   Salud Carlos III; Universidad de Cordoba; Jagiellonian University;
   Collegium Medicum Jagiellonian University; Maastricht University;
   University of Reading
RP Risérus, U (corresponding author), Uppsala Univ, Dept Publ Hlth & Caring Sci Clin Nutr & Metab, Uppsala Sci Pk, S-75185 Uppsala, Sweden.
EM ulf.riserus@pubcare.uu.se
RI Drevon, Christian/F-6012-2010; Ruano, Juan/T-1991-2018; Tierney,
   Audrey/AAB-7068-2022; Lovegrove, Julie/LRV-2592-2024; Lopez-Miranda,
   Jose/Y-8306-2019; Shaw, Danielle/HGA-4994-2022; Blaak, Ellen/E-3459-2015
OI Tierney, Audrey/0000-0001-8562-2877; Blaak, Ellen/0000-0002-2496-3464;
   Lopez-Miranda, Jose/0000-0002-8844-0718; Roche,
   Helen/0000-0002-0628-3318; Ruano, Juan/0000-0002-0286-4107
FU LIPGENE - an European Union [FOOD-CT-2003-505944]; NordForsk (Nordic
   Centre of Excellence in Food, Nutrition and Health (SYSDIET)); Swedish
   Nutrition Foundation; Norwegian Foundation for Health and Rehabilitation
FX We would like to thank all the persons involved in the LIPGENE project
   at all the clinical centres. J. M., H. L. G., A. C. T., S. M., O. H., D.
   I. S., J. A. R., J. L.-M., B. K.-W., I. G., E. E. B., W. H. M. S., C. A.
   D., J. A. L. and H. M. R. designed and organised the original LIPGENE
   study and data collection. U. R. and H. P. conceived the present
   substudy and drafted the manuscript. H. P. performed the statistical
   analyses, and S. B. analysed the oxidative stress markers. All the
   authors contributed to critical revision of the manuscript. The work was
   supported by LIPGENE - an European Union 6th Framework Program
   Integrated Project (FOOD-CT-2003-505944), NordForsk (Nordic Centre of
   Excellence in Food, Nutrition and Health (SYSDIET)), Swedish Nutrition
   Foundation and the Norwegian Foundation for Health and Rehabilitation.
   None of the authors has any conflicts of interest.
CR Basu S, 1998, PROSTAG LEUKOTR ESS, V58, P319, DOI 10.1016/S0952-3278(98)90042-4
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NR 18
TC 29
Z9 32
U1 0
U2 6
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1145
J9 BRIT J NUTR
JI Br. J. Nutr.
PD NOV
PY 2010
VL 104
IS 9
BP 1357
EP 1362
DI 10.1017/S000711451000228X
PG 6
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 677TS
UT WOS:000284015300012
PM 20569506
OA Bronze
DA 2025-06-11
ER

PT J
AU Wan, ST
   Wu, WB
   Zhang, Y
   He, J
   Wang, XP
   An, P
   Luo, JJ
   Zhu, YH
   Luo, YT
AF Wan, Sitong
   Wu, Wenbin
   Zhang, Yan
   He, Jian
   Wang, Xiaoping
   An, Peng
   Luo, Junjie
   Zhu, Yinhua
   Luo, Yongting
TI Antioxidant Lipid Supplement on Cardiovascular Risk Factors: A
   Systematic Review and Meta-Analysis
SO NUTRIENTS
LA English
DT Review
DE antioxidant functional lipids; cardiovascular disease; meta-analysis
ID BETA-CAROTENE; MODERATELY OVERWEIGHT; SCIENTIFIC STATEMENT; OXIDATIVE
   STRESS; NITRIC-OXIDE; DOUBLE-BLIND; VITAMIN-E; DISEASE; ASTAXANTHIN;
   HYPERTENSION
AB The efficacy of functional lipids with antioxidant properties in reducing cardiovascular risk has not been consistent. Randomized controlled trials (RCTs) reporting estimates for the effects of antioxidant functional lipid supplementations on cardiometabolic risk factors were searched up to 1 May 2024. Overall, antioxidant lipid supplementations, compared with placebo, had favorable effects on systolic blood pressure (lycopene: -1.95 [-3.54, -0.36] mmHg), low-density lipoprotein cholesterol (n6 fatty acid: -0.39 [-0.71, -0.06] mmol/L; astaxanthin: -0.11 [-0.21, -0.01] mmol/L), high-density lipoprotein cholesterol (n3 fatty acid: 0.20 [0.13, 0.27] mmol/L; n6 fatty acid: 0.08 [0.01, 0.14] mmol/L; astaxanthin: 0.13 [0.05, 0.21] mmol/L), total cholesterol (n6 fatty acid: -0.24 [-0.37, -0.11] mmol/L; astaxanthin: -0.22 [-0.32, -0.12] mmol/L; beta-carotene: -0.13 [-0.23, -0.04] mmol/L), triglyceride (n3 fatty acid: -0.37 [-0.47, -0.28] mmol/L; astaxanthin: -0.46 [-0.83, -0.10] mmol/L), and fasting blood insulin (astaxanthin: -2.66 [-3.98, -1.34] pmol/L). The benefits of antioxidant lipid supplementations appeared to be most evident in blood pressure and blood lipids in participants with different cardiometabolic health statuses. Notably, n9 fatty acid increased triglyceride and hemoglobin A1C in the total population, which increases CVD risk. Antioxidant lipid supplementations ameliorate cardiometabolic risk factors, while their effect may depend on type and cardiometabolic health status. Long-term RCTs are needed to corroborate risk-benefit ratios across different antioxidant functional lipid supplementation settings.
C1 [Wan, Sitong; Zhang, Yan; Luo, Yongting] Gansu Agr Univ, Coll Food Sci & Engn, Lanzhou 730070, Peoples R China.
   [Wan, Sitong; Wu, Wenbin; An, Peng; Luo, Yongting] China Agr Univ, Dept Nutr & Hlth, Key Lab Precis Nutr & Food Qual, Beijing 100193, Peoples R China.
   [He, Jian] Natl Ctr Technol Innovat Dairy, Hohhot 010110, Peoples R China.
   [Wang, Xiaoping] Zhejiang Med Co Ltd, Shaoxing 312366, Peoples R China.
   [Luo, Junjie] Food Lab Zhongyuan, Luohe 462300, Peoples R China.
   [Zhu, Yinhua] China Acad Chinese Med Sci, Artemisinin Res Ctr, State Key Lab Qual Ensurance & Sustainable Use Dao, Beijing 100700, Peoples R China.
   [Zhu, Yinhua] China Acad Chinese Med Sci, Inst Chinese Mat Med, Beijing 100700, Peoples R China.
C3 Gansu Agricultural University; China Agricultural University; China
   Academy of Chinese Medical Sciences; China Academy of Chinese Medical
   Sciences; Institute of Chinese Materia Medica, CACMS
RP Luo, YT (corresponding author), Gansu Agr Univ, Coll Food Sci & Engn, Lanzhou 730070, Peoples R China.; Luo, YT (corresponding author), China Agr Univ, Dept Nutr & Hlth, Key Lab Precis Nutr & Food Qual, Beijing 100193, Peoples R China.; Luo, JJ (corresponding author), Food Lab Zhongyuan, Luohe 462300, Peoples R China.; Zhu, YH (corresponding author), China Acad Chinese Med Sci, Artemisinin Res Ctr, State Key Lab Qual Ensurance & Sustainable Use Dao, Beijing 100700, Peoples R China.; Zhu, YH (corresponding author), China Acad Chinese Med Sci, Inst Chinese Mat Med, Beijing 100700, Peoples R China.
EM adeline7wan@163.com; wwb091828@163.com; zhangyan@gsau.edu.cn;
   hejian@yili.com; wangxiaoping@zmc.top; an-peng@cau.edu.cn;
   luojj@cau.edu.cn; zhuyinhua@cau.edu.cn; luo.yongting@cau.edu.cn
RI xiaoping, wang/GRX-3807-2022; Zhu, Yinhua/JHU-9736-2023; An,
   Peng/GWZ-9176-2022; Luo, Junjie/HPD-1151-2023
OI Luo, Yongting/0000-0001-7834-8742; Luo, Junjie/0000-0002-8987-0533; Wu,
   Wenbin/0009-0007-2290-4333; An, Peng/0000-0002-0421-0035
FU National Key R&D Program of China [2023YFF1103501]
FX This work was supported by the National Key R&D Program of China
   (2023YFF1103501).
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NR 57
TC 1
Z9 1
U1 4
U2 9
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JUL
PY 2024
VL 16
IS 14
AR 2213
DI 10.3390/nu16142213
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA ZU0K1
UT WOS:001277682100001
PM 39064656
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Park, S
   Kim, M
   Paik, JK
   Jang, YJ
   Lee, SH
   Lee, JH
AF Park, Seonmin
   Kim, Minjoo
   Paik, Jean Kyung
   Jang, Yoon-Jung
   Lee, Sang-Hyun
   Lee, Jong Ho
TI Oxidative stress is associated with C-reactive protein in nondiabetic
   postmenopausal women, independent of obesity and insulin resistance
SO CLINICAL ENDOCRINOLOGY
LA English
DT Article
ID LOW-DENSITY-LIPOPROTEIN; CORONARY-HEART-DISEASE; LIPID-PEROXIDATION;
   METABOLIC SYNDROME; HEALTHY-MEN; CARDIOVASCULAR-DISEASE; IN-VIVO;
   INFLAMMATION; MARKERS; RISK
AB Objective Oxidative stress is associated with obesity, metabolic syndrome and inflammation, suggesting it could be an early event in the pathology of chronic diseases. We tested the hypothesis that elevated levels of oxidative stress markers are associated with increased C-reactive protein (CRP) and that this is independent of obesity and insulin resistance. Research design and methods This study was cross-sectional designed and nondiabetic postmenopausal women (n=1821) with CRP levels 10mg/l was enrolled. The CRP levels were categorized into quartiles from the lowest to the highest concentrations (Q1-Q4). The degree of insulin resistance was determined using the homoeostasis model assessment of insulin resistance (HOMA-IR). We measured oxidative stress using urinary 8-epi-prostaglandin F2 (8-epi-PGF2) and plasma oxidized low-density lipoprotein (ox-LDL). Results After adjustments for age and lifestyle habits, including smoking and drinking, we found higher body mass index (BMI) and HOMA-IR scores in Q2 and Q3 vs Q1. The Q4 BMI and HOMA-IR scores were higher than all other quartiles. The plasma ox-LDL was higher in Q4 than in Q1. Urinary 8-epi-PGF2 was higher in Q3 and Q4 than in Q1 or Q2. Urinary 8-epi-PGF2 positively correlated with CRP (r=0 center dot 235, P<0 center dot 001), whereas no correlation was found between ox-LDL and CRP. Multiple linear regression analyses of BMI and HOMA-IR showed that the association between urinary 8-epi-PGF2 and CRP levels remained significant (P<0 center dot 001). Conclusions Oxidative stress measured by increased concentration of urine 8-epi-PGF2 is strongly associated with CRP levels. This finding was independent of obesity and insulin resistance in nondiabetic postmenopausal women.
C1 [Park, Seonmin; Jang, Yoon-Jung; Lee, Jong Ho] Yonsei Univ, Interdisciplinary Course Sci Aging, Seoul 120749, South Korea.
   [Kim, Minjoo; Lee, Jong Ho] Yonsei Univ, Coll Human Ecol, Dept Food & Nutr, Natl Leading Res Lab Clin Nutrigenet Nutrigen, Seoul 120749, South Korea.
   [Kim, Minjoo; Lee, Jong Ho] Yonsei Univ, Coll Human Ecol, Dept Food & Nutr, Brain Korea Project 21, Seoul 120749, South Korea.
   [Paik, Jean Kyung] Eulji Univ, Dept Food & Nutr, Gyeonggi Do, South Korea.
   [Lee, Sang-Hyun] Natl Hlth Insurance Corp Ilsan Hosp, Dept Family Practice, Goyang Si, South Korea.
C3 Yonsei University; Yonsei University; Yonsei University; Eulji
   University
RP Lee, JH (corresponding author), Yonsei Univ, Coll Human Ecol, Dept Food & Nutr, 134 Shinchon Dong, Seoul 120749, South Korea.
EM jhleeb@yonsei.ac.kr
RI Kim, Minjoo/AEN-5516-2022
FU National Research Foundation, Ministry of Education, Science and
   Technology, Republic of Korea [2012-0005604]; Kyungil University,
   Republic of Korea
FX This study was supported by National Research Foundation, Ministry of
   Education, Science and Technology (Mid-career Researcher Program:
   2012-0005604), Republic of Korea and the Kyungil University Grant,
   Republic of Korea.
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NR 35
TC 16
Z9 16
U1 0
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0300-0664
EI 1365-2265
J9 CLIN ENDOCRINOL
JI Clin. Endocrinol.
PD JUL
PY 2013
VL 79
IS 1
BP 65
EP 70
DI 10.1111/j.1365-2265.2012.04512.x
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 158SP
UT WOS:000319993500010
PM 22816656
DA 2025-06-11
ER

PT J
AU Morvaridzadeh, M
   Qorbani, M
   Eshkiki, ZS
   Estêvao, MD
   Ganjaroudi, NM
   Toupchian, O
   Abdollahi, S
   Pizarro, AB
   Abu-Zaid, A
   Zadro, JR
   Heshmati, J
   Ziaei, S
AF Morvaridzadeh, Mojgan
   Qorbani, Mostafa
   Eshkiki, Zahra Shokati
   Estevao, M. Dulce
   Ganjaroudi, Negar Mohammadi
   Toupchian, Omid
   Abdollahi, Shima
   Beatriz Pizarro, Ana
   Abu-Zaid, Ahmed
   Zadro, Joshua R.
   Heshmati, Javad
   Ziaei, Somayeh
TI The effect of almond intake on cardiometabolic risk factors,
   inflammatory markers, and liver enzymes: A systematic review and
   meta-analysis
SO PHYTOTHERAPY RESEARCH
LA English
DT Review
DE almond; blood lipids; cardiometabolic; glycemic control; hepatic
   enzymes; inflammation
ID TYPE-2 DIABETES-MELLITUS; LIPID PROFILE; BLOOD-PRESSURE; DOSE-RESPONSE;
   CARDIOVASCULAR-DISEASE; NUT PHYTOCHEMICALS; OXIDATIVE STRESS;
   BODY-COMPOSITION; TREE NUTS; VITAMIN-E
AB Almond intake may be correlated with improvements in several cardiometabolic parameters, but its effects are controversial in the published literature, and it needs to be comprehensively summarized. We conducted a systematic search in several international electronic databases, including MEDLINE, EMBASE, Scopus, Web of Science, Cochrane Central Register of Controlled Trials, and until April 2021 to identify randomized controlled trials that examined the effects of almond consumption on cardiometabolic risk factors, inflammatory markers, and liver enzymes. Data were pooled using the random-effects model method and presented as standardized mean differences (SMDs) with 95% confidence intervals (CIs). Twenty-six eligible trials were analyzed (n = 1750 participants). Almond intake significantly decreased diastolic blood pressure, total cholesterol, triglyceride, low-density lipoprotein (LDL), non-high-density lipoprotein (HDL), and very LDL (p < 0.05). The effects of almond intake on systolic blood pressure, fasting blood glucose, insulin, hemoglobin A1c, homeostatic model assessment of insulin resistance, C-peptide, alanine aminotransferase, aspartate aminotransferase, gamma-glutamyl transferase, C-reactive protein (CRP), hs-CRP (high sensitivity C-reactive protein), interleukin 6, tumor necrosis factor-alpha, ICAM (Intercellular Adhesion Molecule), VCAM (Vascular Cell Adhesion Molecule), homocysteine, HDL, ox-LDL, ApoA1, ApoB, and lipoprotien-a were not statistically significant (p > .05). The current body of evidence supports the ingestion of almonds for their beneficial lipid-lowering and antihypertensive effects. However, the effects of almonds on antiinflammatory markers, glycemic control, and hepatic enzymes should be further evaluated via performing more extensive randomized trials.
C1 [Morvaridzadeh, Mojgan; Heshmati, Javad] Kermanshah Univ Med Sci, Songhor Healthcare Ctr, Kermanshah, Iran.
   [Qorbani, Mostafa] Alborz Univ Med Sci, Noncommunicable Dis Res Ctr, Karaj, Iran.
   [Qorbani, Mostafa] Univ Tehran Med Sci, Chron Dis Res Ctr, Endocrinol & Metab Populat Sci Inst, Tehran, Iran.
   [Eshkiki, Zahra Shokati] Ahvaz Jundishapur Univ Med Sci, Alimentary Tract Res Ctr, Clin Sci Reseaech Inst, Ahvaz, Iran.
   [Estevao, M. Dulce] Univ Algarve, Escola Super Saude, Faro, Portugal.
   [Ganjaroudi, Negar Mohammadi] Shahid Beheshti Univ Med Sci, Sch Med, Tehran, Iran.
   [Toupchian, Omid; Abdollahi, Shima] North Khorasan Univ Med Sci, Sch Hlth, Dept Nutr & Publ Hlth, Bojnurd, Iran.
   [Beatriz Pizarro, Ana] Fdnn Valle Lili, Clin Res Ctr, Cali, Colombia.
   [Abu-Zaid, Ahmed] Univ Tennessee, Coll Grad Hlth Sci, Dept Pharmacol, Hlth Sci Ctr, Memphis, TN USA.
   [Zadro, Joshua R.] Univ Sydney, Fac Med & Hlth, Sydney Sch Publ Hlth, Camperdown, NSW, Australia.
   [Ziaei, Somayeh] Kermanshah Univ Med Sci, Emam Reza Hosp, ICU Dept, Kermanshah, Iran.
C3 Kermanshah University of Medical Sciences; Alborz University of Medical
   Sciences; Tehran University of Medical Sciences; Ahvaz Jundishapur
   University of Medical Sciences (AJUMS); Universidade do Algarve; Shahid
   Beheshti University Medical Sciences; North Khorasan University of
   Medical Sciences; University of Tennessee System; University of
   Tennessee Health Science Center; University of Sydney; Kermanshah
   University of Medical Sciences
RP Heshmati, J (corresponding author), Kermanshah Univ Med Sci, Songhor Healthcare Ctr, Kermanshah, Iran.; Qorbani, M (corresponding author), Alborz Univ Med Sci, Noncommunicable Dis Res Ctr, Karaj, Iran.; Ziaei, S (corresponding author), Kermanshah Univ Med Sci, Emam Reza Hosp, ICU Dept, Kermanshah, Iran.
EM mqorbani1379@yahoo.com; javad.heshmati@gmail.com;
   somaye.ziaie@kums.ac.ir
RI Eshkiki, Zahra/ABD-6918-2020; Qorbani, Mostafa/M-8171-2017; Ahmed,
   Ahmed/JHS-7565-2023; heshmati, javad/H-6812-2019; Morvaridzadeh,
   Mojgan/GLU-6418-2022; Zadro, Joshua/AAD-5961-2019; Toupchian,
   Omid/ACR-6829-2022; Pizarro, Ana/AAC-8021-2022; Abdollahi,
   Shima/AAA-8999-2020; Estevao, Dulce/I-4695-2014
OI Pizarro, Ana Beatriz/0000-0003-4089-454X; Abu-Zaid,
   Ahmed/0000-0003-2286-2181; Abdollahi, Shima/0000-0002-2638-7448;
   Estevao, Dulce/0000-0002-7151-8363
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NR 67
TC 8
Z9 8
U1 2
U2 10
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0951-418X
EI 1099-1573
J9 PHYTOTHER RES
JI Phytother. Res.
PD DEC
PY 2022
VL 36
IS 12
BP 4325
EP 4344
DI 10.1002/ptr.7622
EA NOV 2022
PG 20
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 6W1BK
UT WOS:000878605700001
PM 36331011
OA Green Published
DA 2025-06-11
ER

PT J
AU Drake, C
   Lian, T
   Trogdon, JG
   Edelman, D
   Eisenson, H
   Weinberger, M
   Reiter, K
   Shea, CM
AF Drake, Connor
   Lian, Tyler
   Trogdon, Justin G.
   Edelman, David
   Eisenson, Howard
   Weinberger, Morris
   Reiter, Kristin
   Shea, Christopher M.
TI Evaluating the association of social needs assessment data with
   cardiometabolic health status in a federally qualified community health
   center patient population
SO BMC CARDIOVASCULAR DISORDERS
LA English
DT Article
DE Social determinants of health; Social needs; Primary care; Predictive
   analytics; Electronic health record
ID DETERMINANTS; RISK; MEDICARE; TOOLS
AB Background Health systems are increasingly using standardized social needs screening and response protocols including the Protocol for Responding to and Assessing Patients' Risks, Assets, and Experiences (PRAPARE) to improve population health and equity; despite established relationships between the social determinants of health and health outcomes, little is known about the associations between standardized social needs assessment information and patients' clinical condition. Methods In this cross-sectional study, we examined the relationship between social needs screening assessment data and measures of cardiometabolic clinical health from electronic health records data using two modelling approaches: a backward stepwise logistic regression and a least absolute selection and shrinkage operation (LASSO) logistic regression. Primary outcomes were dichotomized cardiometabolic measures related to obesity, hypertension, and atherosclerotic cardiovascular disease (ASCVD) 10-year risk. Nested models were built to evaluate the utility of social needs assessment data from PRAPARE for risk prediction, stratification, and population health management. Results Social needs related to lack of housing, unemployment, stress, access to medicine or health care, and inability to afford phone service were consistently associated with cardiometabolic risk across models. Model fit, as measured by the c-statistic, was poor for predicting obesity (logistic = 0.586; LASSO = 0.587), moderate for stage 1 hypertension (logistic = 0.703; LASSO = 0.688), and high for borderline ASCVD risk (logistic = 0.954; LASSO = 0.950). Conclusions Associations between social needs assessment data and clinical outcomes vary by cardiometabolic condition. Social needs assessment data may be useful for prospectively identifying patients at heightened cardiometabolic risk; however, there are limits to the utility of social needs data for improving predictive performance.
C1 [Drake, Connor; Lian, Tyler] Duke Univ, Dept Populat Hlth Sci, Sch Med, 215 Morris St, Durham, NC 27701 USA.
   [Drake, Connor; Trogdon, Justin G.; Weinberger, Morris; Reiter, Kristin; Shea, Christopher M.] Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Hlth Policy & Management, 135 Dauer Dr, Chapel Hill, NC 27519 USA.
   [Edelman, David] Duke Univ, Sch Med, Dept Med, 2301 Erwin Rd, Durham, NC 27705 USA.
   [Edelman, David] Durham VA Healthcare Syst, 508 Fulton St, Durham, NC 27705 USA.
   [Eisenson, Howard] Lincoln Community Hlth Ctr, 1301 Fayetteville St, Durham, NC 27707 USA.
   [Eisenson, Howard] Duke Univ, Sch Med, Dept Family Med & Community Hlth, DUMC 2914, Durham, NC 27710 USA.
C3 Duke University; University of North Carolina; University of North
   Carolina Chapel Hill; Duke University; Duke University
RP Drake, C (corresponding author), Duke Univ, Dept Populat Hlth Sci, Sch Med, 215 Morris St, Durham, NC 27701 USA.
EM connor.drake@duke.edu
OI Edelman, David/0000-0001-7112-6151; Drake, Connor/0000-0002-5393-6246
FU BlueCross BlueShield of North Carolina Foundation; National Heart, Lung,
   And Blood Institute of the National Institutes of Health [K12HL138030];
   National Heart Lung and Blood Institute [K12HL138030] Funding Source:
   NIH RePORTER
FX This study was supported in part by the BlueCross BlueShield of North
   Carolina Foundation and by the National Heart, Lung, And Blood Institute
   of the National Institutes of Health under Award Number K12HL138030.
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NR 48
TC 11
Z9 11
U1 0
U2 8
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1471-2261
J9 BMC CARDIOVASC DISOR
JI BMC Cardiovasc. Disord.
PD JUL 14
PY 2021
VL 21
IS 1
AR 342
DI 10.1186/s12872-021-02149-5
PG 10
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Cardiovascular System & Cardiology
GA TM2KW
UT WOS:000675381400002
PM 34261446
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Burgueño, AL
   Juárez, YR
   Genaro, AM
   Tellechea, ML
AF Burgueno, Adriana L.
   Juarez, Yamila R.
   Genaro, Ana M.
   Tellechea, Mariana L.
TI Prenatal stress and later metabolic consequences: Systematic review and
   meta-analysis in rodents
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Review
DE Low birth weight; Maternal stress; Corticosteroids; Metabolic syndrome;
   Systolic blood pressure
ID FAT-SUCROSE DIET; LOW-BIRTH-WEIGHT; PSYCHOSOCIAL STRESS;
   SEXUAL-BEHAVIOR; BLOOD-PRESSURE; ADULT HEALTH; DISEASE RISK; OUTCOMES;
   CHILDHOOD; EXPOSURE
AB Background: Numerous rodent studies have evaluated the effects of maternal stress (MS) on later in life susceptibility to Metabolic Syndrome (MetS) intermediate phenotypes with varying results. The aim of this study was to quantitatively synthesize the available data on the effects of MS on offspring obesity, estimated indirectly by body mass (BM), body fat (BF) and plasma leptin; systolic blood pressure (SBP); plasma glucose (and insulin) and blood lipid concentrations.
   Methods: Literature was screened and summary estimates of the effect of MS outcomes were calculated by using random-effects models. Data on the effects of exogenous corticosteroid administration (or inhibition of 11 beta-HSD2) during pregnancy in rodents was analysed separately to characterize the direct phenotypic effects of prenatal corticosteroid excess (PCE).
   Results: We conducted 14 separate meta-analyses and synthesized relevant data on outcomes scarcely reported in literature. Both MS and PCE were associated with low birth weight without rapid catch-up growth resulting in decreased body mass later in life. Our analysis also revealed significant and contradictory effects on offspring adiposity. Little evidence was found for effects on glucose metabolism and blood lipids. We identified increased SBP in offspring exposed to PCE; however, there is not enough data to draw any conclusion about effects of MS on SBP.
   Conclusions: Neonatal weight proved to be decreased in offspring prenatally exposed to stress or corticosteroids, but laboratory rodents in the absence of a challenging environment did not show catch-up growth. The available evidence is inconclusive regarding the effect on adiposity revealing clear methodological and knowledge gaps. This meta-analysis also confirmed a significant positive association between PCE and SBP. Nevertheless, additional studies should address the association with MS.
C1 [Burgueno, Adriana L.; Juarez, Yamila R.; Genaro, Ana M.] Pontificia Univ Catolica Argentina, Inst Invest Biomed, CONICET, Alicia Moreau de Justo 1600,C1107AFF, Buenos Aires, DF, Argentina.
   [Tellechea, Mariana L.] Hosp Ninos Dr Ricardo Gutierrez, Div Endocrinol, Fdn Endocrinol Infanta, Ctr Invest Endocrinol Dr Cesar Bergad,Consejo Nac, Gallo 1330,C1425EFD, Buenos Aires, DF, Argentina.
C3 Pontificia Universidad Catolica Argentina; Consejo Nacional de
   Investigaciones Cientificas y Tecnicas (CONICET); Hospital de Ninos
   Doctor Ricardo Gutierrez; University of Buenos Aires; University of
   Buenos Aires Hospital
RP Tellechea, ML (corresponding author), Hosp Ninos Dr Ricardo Gutierrez, Div Endocrinol, Fdn Endocrinol Infanta, Ctr Invest Endocrinol Dr Cesar Bergad,Consejo Nac, Gallo 1330,C1425EFD, Buenos Aires, DF, Argentina.
EM alburgueno@conicet.gov.ar; yamila_juarez@uca.edu.ar;
   ana_genaro@uca.edu.ar; mtellechea@cedie.org.ar
RI TELLECHEA, MARIANA/AAM-6673-2021
OI TELLECHEA, MARIANA LORENA/0000-0002-1194-8433; Burgueno, Adriana
   L./0000-0001-7584-7044; Genaro, Ana/0000-0003-0027-3503
FU ANPCyT [PICT-2015-1567, PICT-2016-2727]; CONICET [PIP-2015-No0163]
FX This study was partially supported by ANPCyT (grants PICT-2015-1567,
   PICT-2016-2727) and CONICET (grant PIP-2015-No0163). ALB, AMG, and MLT
   are members of CONICET.
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NR 52
TC 20
Z9 23
U1 0
U2 6
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
EI 1873-3360
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD MAR
PY 2020
VL 113
AR 104560
DI 10.1016/j.psyneuen.2019.104560
PG 8
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA LD3MV
UT WOS:000525937600022
PM 31884321
OA Green Published
DA 2025-06-11
ER

PT J
AU Flores-Fuentes, N
   Hernandez-Cruz, C
   Bermeo, K
   Barajas-Martinez, A
   Hernandez-Serratos, VN
   Aceves-Rodriguez, EM
   Martinez-Alonso, E
   Castro, H
   Martinez-Huerta, MI
   Elias-Viñas, D
   Salazar-Anguiano, J
   Arenas, I
   Garcia, DE
AF Flores-Fuentes, Nayely
   Hernandez-Cruz, Carolina
   Bermeo, Karina
   Barajas-Martinez, Antonio
   Nayely Hernandez-Serratos, Valeria
   Mauricio Aceves-Rodriguez, Erick
   Martinez-Alonso, Eduardo
   Castro, Hector
   Irel Martinez-Huerta, Maricela
   Elias-Vinas, David
   Salazar-Anguiano, Jeny
   Arenas, Isabel
   Garcia, David E.
TI Motor learning impairment in rats under a high sucrose diet
SO PHYSIOLOGY & BEHAVIOR
LA English
DT Article
DE Rotarod; Open field test; Elevated plus-maze; Anxiety-like behavior;
   TNF-alpha
ID METABOLIC SYNDROME; MEMORY-SYSTEMS; BRAIN; BEHAVIOR; COORDINATION;
   LESIONS; SKILL; ACQUISITION; OBESITY; STRESS
AB Motor learning skills are reliable indicators of behavioral acquisition and cognitive disorders. The ease with which learning skills are measured disparities the complexity of the interpretation concerning neural plasticity. Conversely, a wealth of information regarding metabolic derangements has long been reported with direct connection to high sucrose diets. However, the impact of excessive sucrose consumption on undergoing cognitive processes has been only scarcely addressed up to now. Therefore, the goal of this work was to describe the associative relationship between high sucrose consumption and changes in motor learning skills acquisition. Motor learning impairments conditioned by central alterations are hypothesized. Rotarod, elevated plus-maze and open field trials, along with metabolic and pro-inflammatory biomarkers tests in Wistar rats under a high sucrose treatment, were performed. Motor learning impairment in high sucrose diet-treated rats was found while spontaneous locomotor activity remained unchanged. Even though, no anxiety-like behavior under high sucrose diet-treatment was observed. Consistently, the worst outcome in the glucose tolerance test was developed, the worst motor learning performance was observed. Furthermore, insulin resistance correlated positively with a pro-inflammatory state and a decreased latency to fall in the rotarod test. Indeed, C-reactive protein and tumor necrosis factor-alpha serum levels, along with the homeostasis model assessment of insulin resistance (HOMA-IR), significantly increased in motor learning impairment. Together, these results support behavioral, metabolic and pro-inflammatory changes associated with deleterious changes in central nervous system likely involving crucial motor learning structures. Underlying pro-inflammatory-triggered processes may explain cognitive disorders in advanced states of metabolic derangements.
C1 [Flores-Fuentes, Nayely; Hernandez-Cruz, Carolina; Bermeo, Karina; Barajas-Martinez, Antonio; Nayely Hernandez-Serratos, Valeria; Mauricio Aceves-Rodriguez, Erick; Martinez-Alonso, Eduardo; Castro, Hector; Irel Martinez-Huerta, Maricela; Arenas, Isabel; Garcia, David E.] Univ Nacl Autonoma Mexico, Sch Med, Dept Physiol, POB 70250, Mexico City 04510, DF, Mexico.
   [Elias-Vinas, David; Salazar-Anguiano, Jeny] Inst Politecn Nacl, Dept Elect Engn, Sect Bioelect, Ctr Invest & Estudios Avanzados, POB 14740, Mexico City 07000, DF, Mexico.
C3 Universidad Nacional Autonoma de Mexico; CINVESTAV - Centro de
   Investigacion y de Estudios Avanzados del Instituto Politecnico
   Nacional; Instituto Politecnico Nacional - Mexico
RP Garcia, DE (corresponding author), Univ Nacl Autonoma Mexico, Sch Med, Dept Physiol, POB 70250, Mexico City 04510, DF, Mexico.
EM erasmo@unam.mx
RI Arenas, Isabel/A-7622-2008; Bermeo, Karina/MFH-2144-2025; Garcia,
   David/AAE-8176-2020; Barajas-Martinez, Antonio/GLR-1196-2022
OI Flores-Fuentes, Nayely/0000-0002-0354-9715; Bermeo,
   Karina/0000-0003-3274-1412; Barajas-Martinez,
   Antonio/0000-0002-5299-0259
FU Alexander von Humboldt Stiftung, Germany [IN216119]; Consejo Nacional de
   Ciencia y Tecnologia (CONACyT) [255635]; Academy of Finland (AKA)
   [255635] Funding Source: Academy of Finland (AKA)
FX This work was supported by the Alexander von Humboldt Stiftung, Germany
   to DEG, UNAM-DGAPA-PAPIIT [grant number IN216119], and Consejo Nacional
   de Ciencia y Tecnologia (CONACyT) [grant number 255635]. We thank Ing.
   Esteban Ruiz Hernandez for electronic support. Dr. Maria De La Luz
   Navarro from the Department of Physiology, School of Medicine, UNAM, for
   providing one of the rotarod equipment.
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NR 57
TC 8
Z9 8
U1 0
U2 6
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0031-9384
EI 1873-507X
J9 PHYSIOL BEHAV
JI Physiol. Behav.
PD MAY 15
PY 2021
VL 234
AR 113384
DI 10.1016/j.physbeh.2021.113384
EA MAR 2021
PG 9
WC Psychology, Biological; Behavioral Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Behavioral Sciences
GA RN2MU
UT WOS:000640186900010
PM 33676960
DA 2025-06-11
ER

PT J
AU Wu, Q
   Hua, YY
   Ma, QH
   Xu, Y
   Chen, X
   Pan, CW
AF Wu, Qian
   Hua, Yi-Ying
   Ma, Qing-Hua
   Xu, Yong
   Chen, Xing
   Pan, Chen-Wei
TI Depressive symptoms and 5-year incident metabolic syndrome among older
   adults
SO SCIENTIFIC REPORTS
LA English
DT Article
ID BLOOD-PRESSURE; ASSOCIATION; ANXIETY; RISK; HEALTH; TEA; HYPERTENSION;
   METAANALYSIS; PREVALENCE; DISEASE
AB Little is known regarding the association between depressive symptoms and metabolic syndrome (MetS) among older Chinese adults. This study aimed to examine the association of depressive symptoms with MetS and its components among Chinese elderly. Based on whether they showed depressive symptoms at baseline, 262 age-gender-matched participants from a community-based cohort study were included. The presence of depressive symptoms was measured using the nine-item Patient Health Questionnaire (PHQ-9). MetS was defined according to the Adult Treatment Panel III of the National Cholesterol Education Program. Linear regression and logistic regression analyses were performed to assess associations of depressive symptoms with MetS and its components. The incidence of MetS among the participants with depressive symptoms at baseline was 15.27% (20/131). The association of the presence of depressive symptoms with MetS was significant (odds ratio [OR] = 2.53, 95% confidence intervals [CI] = 1.07, 5.95). There was a negative association between depressive symptoms and hypertension (OR = 0.04, 95% CI = 0.002, 0.98). The change in mean arterial pressure varies approximately 1.03 mmHg with a 1-point change in PHQ-9 score. In this study, baseline depressive symptoms were associated with subsequent MetS. The presence of depressive symptoms was negatively associated with elevated mean arterial pressure.
C1 [Wu, Qian; Hua, Yi-Ying; Xu, Yong; Pan, Chen-Wei] Soochow Univ, Sch Publ Hlth, Med Coll, 199 Ren Ai Rd, Suzhou 215123, Peoples R China.
   [Ma, Qing-Hua] 3rd Peoples Hosp Xiangcheng Dist, Suzhou, Peoples R China.
   [Chen, Xing] Nanjing Med Univ, Affiliated Suzhou Hosp, Dept Children Hlth Care, 26 Dao Qian Rd, Suzhou 215000, Peoples R China.
C3 Soochow University - China; Nanjing Medical University
RP Pan, CW (corresponding author), Soochow Univ, Sch Publ Hlth, Med Coll, 199 Ren Ai Rd, Suzhou 215123, Peoples R China.; Chen, X (corresponding author), Nanjing Med Univ, Affiliated Suzhou Hosp, Dept Children Hlth Care, 26 Dao Qian Rd, Suzhou 215000, Peoples R China.
EM cx1708@126.com; pcwonly@gmail.com
RI Ma, Qinghua/KPA-8692-2024; Pan, Chen-Wei/L-7174-2019; xing,
   chen/AFQ-8607-2022
FU Science and Technology Bureau of Xiangcheng District in Suzhou, China
   [XJ201706, GSWS2019090]
FX This study was supported by the Science and Technology Bureau of
   Xiangcheng District in Suzhou, China under Grant nos. XJ201706 and
   GSWS2019090.
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NR 55
TC 6
Z9 6
U1 1
U2 9
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD JUL 21
PY 2021
VL 11
IS 1
AR 14842
DI 10.1038/s41598-021-94503-y
PG 8
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Science & Technology - Other Topics
GA UD6MB
UT WOS:000687318300001
PM 34290362
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Méndez, L
   Pazos, M
   Giralt, M
   Nogués, MR
   Pérez-Jiménez, J
   Torres, JL
   Gallardo, JM
   Medina, I
AF Mendez, Lucia
   Pazos, Manuel
   Giralt, Montserrat
   Nogues, M. Rosa
   Perez-Jimenez, Jara
   Torres, Josep L.
   Gallardo, J. M.
   Medina, Isabel
TI Targets of protein carbonylation in spontaneously hypertensive obese
   Koletsky rats and healthy Wistar counterparts: A potential role on
   metabolic disorders
SO JOURNAL OF PROTEOMICS
LA English
DT Article
DE Metabolic syndrome; SHROB model; Wistar rat; Oxidative stress; Redox
   proteomics; Protein carbonylation
ID OXIDATIVE STRESS; INSULIN-RESISTANCE; GRAPE SEED; GENERATION; TISSUE;
   HYPERTRIGLYCERIDEMIA; IDENTIFICATION; CARBOHYDRATE; DYSFUNCTION;
   PROTEOMICS
AB The study innovatively pinpoints target proteins of carbonylation, a key PTM induced by oxidative stress, in the SHROB (genetically obese spontaneously hypertensive) rat model of metabolic syndrome (MetS). Protein carbonylation was assessed by a fluorescence-labeling proteomics approach, and complemented with biometric and biochemical. markers of MetS. SHROB and healthy Wistar rats were fed two diets, soybean and linseed oil supplementations, in order to distinguish intrinsic carbonylation of SHROB animals from diet-modulated carbonylation unrelated to MetS. First exploratory data showed similar carbonylation patterns and metabolic conditions in SHROB rats fed soybean and linseed, but different from Wistar animals. A total of 18 carbonylated spots in liver, and 12 in skeletal tissue, related to pathways of lipid (29.6%), carbohydrate (25.9%) and amino acid (18.5%) metabolisms, were identified. In particular, SHROB animals present higher carbonylation in four liver proteins belonging to lipid metabolism, redox regulation and chaperone activity (ALDH2, PDI, PDIA3, PECR), and in the skeletal muscle ALDOA that is involved in muscle dysfunction. Conversely, SHROB rats display lower carbonylation in liver albumin, AKR1C9, ADH1 and catalase. This investigation provides a novel perspective of carbonylation in the context of metabolic disorders, and maybe a starting point to characterize new redox pathways exacerbating MetS.
   Biological significance
   Oxidative stress is a concomitant factor in the pathogenesis of MetS that induces oxidative PTM as carbonylation. Through the use of a redox proteomics approach, we have thoroughly mapped the occurrence of protein targets of carbonylation in the genetically-induced MetS model SHROB rat. The present research brings anew insight of MetS pathogenesis and it may provide valuable information to understand the biological impact of oxidative stress in patients with MetS. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Mendez, Lucia; Pazos, Manuel; Gallardo, J. M.; Medina, Isabel] CSIC, IIM, E-36208 Vigo, Spain.
   [Perez-Jimenez, Jara; Torres, Josep L.] CSIC, IQAC, E-08034 Barcelona, Spain.
   [Giralt, Montserrat; Nogues, M. Rosa] Univ Rovira & Virgili, Fac Med & Ciencias Salud, Unidad Farmacol, E-43201 Reus, Spain.
C3 Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Instituto
   de Investigaciones Marinas (IIM); Consejo Superior de Investigaciones
   Cientificas (CSIC); CSIC - Centro de Investigacion y Desarrollo Pascual
   Vila (CID-CSIC); CSIC - Instituto de Quimica Avanzada de Cataluna
   (IQAC); Universitat Rovira i Virgili
RP Pazos, M (corresponding author), CSIC, IIM, Eduardo Cabello 6, E-36208 Vigo, Spain.
EM mpazos@iim.csic.es
RI MEDINA, ISABEL/AAL-4012-2021; Nogués, M./ABH-5645-2020; Perez-Jimenez,
   Jara/B-3989-2009; Torres, Josep/N-7256-2013; Pazos, Manuel/N-5007-2014;
   Mendez, Lucia/T-7016-2017; Montserrat, Giralt/I-3905-2015
OI MEDINA, ISABEL/0000-0002-1854-3359; Torres, Josep/0000-0002-5072-8265;
   Pazos, Manuel/0000-0003-1571-5730; Mendez, Lucia/0000-0002-9711-2994;
   Montserrat, Giralt/0000-0002-7073-577X; Perez-Jimenez,
   Jara/0000-0002-2811-4558
FU Spanish Ministry of Science and Innovation [AGL2009-12374-C03-01, -02,
   -03]; Spanish Ministry of Science and Innovation; USC (Spain);
   postdoctoral "Isidro Parga Pondal"; Instituto de Salud Carlos III
   [CD09/00068]
FX This investigation has been supported by the Spanish Ministry of Science
   and Innovation (Grant AGL2009-12374-C03-01, -02 and -03). The Spanish
   Ministry of Science and Innovation is gratefully acknowledged for the
   doctoral fellowship to L.M. L.M. also thanks the USC (Spain) for its
   doctoral program. Xunta de Galicia and European Social Fund are
   thankfully recognized by the financial support of the postdoctoral
   "Isidro Parga Pondal" contract to M.P. J.P.-J. thanks the Spanish
   Ministry of Science and Innovation and the Instituto de Salud Carlos III
   for granting her a Sara Borrell postdoctoral contract (CD09/00068). The
   authors thank Mrs. Lorena Barros for her excellent technical assistance.
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NR 48
TC 14
Z9 14
U1 0
U2 20
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1874-3919
EI 1876-7737
J9 J PROTEOMICS
JI J. Proteomics
PD JUN 25
PY 2014
VL 106
BP 246
EP 259
DI 10.1016/j.jprot.2014.04.036
PG 14
WC Biochemical Research Methods
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA AK7QB
UT WOS:000338621700019
PM 24793432
DA 2025-06-11
ER

PT J
AU Weiss, C
   Kornicka-Grabowska, K
   Mularczyk, M
   Siwinska, N
   Marycz, K
AF Weiss, C.
   Kornicka-Grabowska, K.
   Mularczyk, M.
   Siwinska, N.
   Marycz, K.
TI Extracellular Microvesicles (MV's) Isolated from
   5-Azacytidine-and-Resveratrol-Treated Cells Improve Viability and
   Ameliorate Endoplasmic Reticulum Stress in Metabolic Syndrome Derived
   Mesenchymal Stem Cells
SO STEM CELL REVIEWS AND REPORTS
LA English
DT Article
DE Stem cells; Extracellular vesicles; Rejuvenation
ID AUTOPHAGY; DEATH; REGENERATION; MECHANISM; PROTECT; TISSUE
AB Extracellular vesicles (EVs), a spherical membrane fragments including exosomes, are released from several cell types, including mesenchymal stromal cells (MSCs), constitutively or under stimulation. As MVs cargo include DNA, RNA, miRNA, lipids and proteins their have gain special attention in the field of regenerative medicine. Depending on the type of transferred molecules, MVs may exert wide range of biological effects in recipient cells including pro-inflammatory and anti-apoptotic action. In presented paper, we isolated MVs form adipose derived mesenchymal stem cells (ASC) which underwent stimulation with 5-azacytydine and resveratrol (AZA/RES) in order to improve their therapeutic potential. Then, isolated MVs were applied to ASC with impaired cytophysiological properties, isolated from equine metabolic syndrome diagnosed animals. Using RT-PCR, immunofluorescence, ELISA, confocal microscopy and western blot, we have evaluated the effects of MVs on recipient cells. We have found, that MVs derived from AZA/RES treated ASC ameliorates apoptosis, senescence and endoplasmic reticulum (ER) stress in deteriorated cells, restoring their proper functions. The work indicates, that cells treated with AZA/RES through their paracrine action can rejuvenate recipient cells. However, further research needs to be performed in order to fully understand the molecular mechanisms of these bioactive factors action.
C1 [Weiss, C.] PferdePraxis Dr Med Vet Daniel Weiss, Postmatte 14, CH-8807 Freienbach, Switzerland.
   [Kornicka-Grabowska, K.; Mularczyk, M.; Marycz, K.] Wroclaw Univ Environm & Life Sci, Dept Expt Biol, Norwida 27B St,A7 Bldg, PL-50375 Wroclaw, Poland.
   [Kornicka-Grabowska, K.; Mularczyk, M.; Marycz, K.] Int Inst Translat Med, Jesionowa 11, PL-55114 Wisznia Mala, Poland.
   [Siwinska, N.] Wroclaw Univ Environm & Life Sci, Fac Vet Med, Dept Internal Med & Clin Dis Horses Dogs & Cats, Pl Grunwaldzki 47, PL-50366 Wroclaw, Poland.
   [Marycz, K.] Justus Liebig Univ, Fac Vet Med, Equine Clin Equine Surg, D-35392 Giessen, Germany.
C3 Wroclaw University of Environmental & Life Sciences; Wroclaw University
   of Environmental & Life Sciences; Justus Liebig University Giessen
RP Marycz, K (corresponding author), Wroclaw Univ Environm & Life Sci, Dept Expt Biol, Norwida 27B St,A7 Bldg, PL-50375 Wroclaw, Poland.; Marycz, K (corresponding author), Int Inst Translat Med, Jesionowa 11, PL-55114 Wisznia Mala, Poland.; Marycz, K (corresponding author), Justus Liebig Univ, Fac Vet Med, Equine Clin Equine Surg, D-35392 Giessen, Germany.
EM krzysztofmarycz@interia.pl
FU grant "Modulation mitochondrial metabolism and dynamics and targeting
   DNA methylation of adipose derived mesenchymal stromal stem cell (ASC)
   using resveratrol and 5-azacytydin as a therapeutic strategy in the
   course of Equine metabolic syndrome (EMS)" by T [2016/21/B/NZ7/01111];
   grant "Inhibition of tyrosine phosphatase as a strategy to enhance
   insulin sensitivity through activation of chaperone mediated autophagy
   and amelioration of inflammation and cellular stress in the liver of
   equinemetabolic syndrome (EMS) horses" by The Nat [2018/29/B/NZ7/02662]
FX This project was financed within the framework of a grants entitled
   "Modulation mitochondrial metabolism and dynamics and targeting DNA
   methylation of adipose derived mesenchymal stromal stem cell (ASC) using
   resveratrol and 5-azacytydin as a therapeutic strategy in the course of
   Equine metabolic syndrome (EMS)." (grant no. 2016/21/B/NZ7/01111) and
   "Inhibition of tyrosine phosphatase as a strategy to enhance insulin
   sensitivity through activation of chaperone mediated autophagy and
   amelioration of inflammation and cellular stress in the liver of
   equinemetabolic syndrome (EMS) horses." (grant no. 2018/29/B/NZ7/02662)
   financed by The National Science Centre in Poland.
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NR 47
TC 15
Z9 15
U1 0
U2 13
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 2629-3269
EI 2629-3277
J9 STEM CELL REV REP
JI Stem Cell Rev. Rep.
PD DEC
PY 2020
VL 16
IS 6
BP 1343
EP 1355
DI 10.1007/s12015-020-10035-4
EA SEP 2020
PG 13
WC Cell & Tissue Engineering; Cell Biology; Medicine, Research &
   Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Research & Experimental Medicine
GA OR7EN
UT WOS:000565828800002
PM 32880856
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Peleli, M
   Ferreira, DMS
   Tarnawski, L
   Haworth, SM
   Xuechen, L
   Zhuge, Z
   Newton, PT
   Massart, J
   Chagin, AS
   Olofsson, PS
   Ruas, JL
   Weitzberg, E
   Lundberg, JO
   Carlström, M
AF Peleli, M.
   Ferreira, D. M. S.
   Tarnawski, L.
   Haworth, S. McCann
   Xuechen, L.
   Zhuge, Z.
   Newton, P. T.
   Massart, J.
   Chagin, A. S.
   Olofsson, P. S.
   Ruas, J. L.
   Weitzberg, E.
   Lundberg, J. O.
   Carlstrom, M.
TI Dietary nitrate attenuates high-fat diet-induced obesity via mechanisms
   involving higher adipocyte respiration and alterations in inflammatory
   status
SO REDOX BIOLOGY
LA English
DT Article
DE Inorganic nitrate; Metabolic syndrome; Mitochondria; Visceral fat;
   Inflammation; Thermogenesis
ID INORGANIC NITRATE; NITRIC-OXIDE; ADIPOSE-TISSUE; ACTIVATED MACROPHAGES;
   OXIDATIVE STRESS; MICE; THERMOGENESIS; MODULATION; REDUCTION
AB Emerging evidence indicates that dietary nitrate can reverse several features of the metabolic syndrome, but the underlying molecular mechanisms still remain elusive. The aim of the present study was to explore mechanisms involved in the effects of dietary nitrate on the metabolic dysfunctions induced by high-fat diet (HFD) in mice. Four weeks old C57BL/6 male mice, exposed to HFD for ten weeks, were characterised by increased body weight, fat content, increased fasting glucose and impaired glucose clearance. All these metabolic abnormalities were significantly attenuated by dietary nitrate. Mechanistically, subcutaneous primary mouse adipocytes exposed to palmitate (PA) and treated with nitrite exhibited higher mitochondrial respiration, increased protein expression of total mitochondrial complexes and elevated gene expression of the thermogenesis gene UCP-1, as well as of the creatine transporter SLC6A8. Finally, dietary nitrate increased the expression of anti-inflammatory markers in visceral fat, plasma and bone marrow-derived macrophages (Arginase-1, Egr-2, IL-10), which was associated with reduction of NADPH oxidase-derived superoxide production in macrophages. In conclusion, dietary nitrate may have therapeutic utility against obesity and associated metabolic complications possibly by increasing adipocyte mitochondrial respiration and by dampening inflammation and oxidative stress.
C1 [Peleli, M.; Ferreira, D. M. S.; Haworth, S. McCann; Xuechen, L.; Zhuge, Z.; Newton, P. T.; Chagin, A. S.; Ruas, J. L.; Weitzberg, E.; Lundberg, J. O.; Carlstrom, M.] Karolinska Inst, Dept Physiol & Pharmacol, Stockholm, Sweden.
   [Tarnawski, L.; Olofsson, P. S.] Karolinska Inst, Ctr Mol Med, Dept Med, Stockholm, Sweden.
   [Tarnawski, L.; Olofsson, P. S.] Karolinska Univ Hosp, Stockholm, Sweden.
   [Massart, J.] Karolinska Inst, Dept Mol Med & Surg Integrat Physiol, S-17177 Stockholm, Sweden.
   [Chagin, A. S.] Sechenov Univ, Inst Regenerat Med, Moscow, Russia.
   [Weitzberg, E.] Karolinska Inst, Dept Womens & Childrens Hlth, Stockholm, Sweden.
C3 Karolinska Institutet; Karolinska Institutet; Karolinska Institutet;
   Karolinska University Hospital; Karolinska Institutet; Sechenov First
   Moscow State Medical University; Karolinska Institutet
RP Carlström, M (corresponding author), Karolinska Inst, Biomedicum, Dept Physiol & Pharmacol, 5B,Solnavagen 9, S-17165 Solna, Sweden.
EM mattias.carlstrom@ki.se
RI Massart, Julie/AAA-3077-2019; Peleli, Maria/AAQ-2326-2021; Tarnawski,
   Laura/ABB-1979-2020; Chagin, Andrei/F-4080-2014; Sacramento Ferreira,
   Duarte Miguel/E-4270-2012; Carlstrom, Mattias/E-7350-2015; Ruas,
   Jorge/T-3040-2017
OI Chagin, Andrei/0000-0002-2696-5850; Tarnawski,
   Laura/0000-0001-7993-0232; Newton, Phillip/0000-0003-2142-1798; McCann
   Haworth, Sarah/0000-0002-4299-5486; Lundberg, Jon/0000-0002-0174-5210;
   Sacramento Ferreira, Duarte Miguel/0000-0001-5940-7102; Carlstrom,
   Mattias/0000-0001-9923-8729; Massart, Julie/0000-0001-8213-5459; Ruas,
   Jorge/0000-0002-1110-2606
FU Swedish Research Council [2016-01381, 2016-00785]; Swedish Heart and
   Lung Foundation [20140448, 20170124]; Novo Nordisk [0055026]; EFSD/Lilly
   European Diabetes Research Programme [97012]; Karolinska Institutet,
   Stockholm, Sweden [2-560/2015]; KID funding from the Karolinska
   Institutet, Stockholm, Sweden [2-3707/2013, 2-1930/2016]; Swedish
   Research Council [2016-00785] Funding Source: Swedish Research Council
FX We thank Carina Nihlen, Annika Olsson, Margareta Stensdotter (Karolinska
   Institutet, Stockholm, Sweden) for their technical assistance. Marie
   Bjornholm, Anna Krook and the Animal metabolic research facility at the
   Strategic Research Programme in Diabetes at Karolinska Institutet for
   scientific input and help with the metabolism cages. This work was
   supported by grants from the Swedish Research Council (2016-01381 and
   2016-00785), the Swedish Heart and Lung Foundation (20140448 &
   20170124), Novo Nordisk (2019#0055026), and by EFSD/Lilly European
   Diabetes Research Programme (2018#97012), as well as Research Funds
   (2-560/2015) and KID funding (2-3707/2013 & 2-1930/2016) from the
   Karolinska Institutet, Stockholm, Sweden.
CR [Anonymous], FREE RADIC BIOL M S1
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NR 45
TC 35
Z9 38
U1 0
U2 11
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2213-2317
J9 REDOX BIOL
JI Redox Biol.
PD JAN
PY 2020
VL 28
AR 101387
DI 10.1016/j.redox.2019.101387
PG 8
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA JU2FG
UT WOS:000501490700027
PM 31765889
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Goudarzi, R
   Sedaghat, M
   Hedayati, M
   Hekmatdoost, A
   Sohrab, G
AF Goudarzi, Razieh
   Sedaghat, Meghdad
   Hedayati, Mehdi
   Hekmatdoost, Azita
   Sohrab, Golbon
TI Low advanced Glycation end product diet improves the central obesity,
   insulin resistance and inflammatory profiles in Iranian patients with
   metabolic syndrome: a randomized clinical trial
SO JOURNAL OF DIABETES AND METABOLIC DISORDERS
LA English
DT Article
DE Metabolic syndrome; Obesity; Advanced glycation end products;
   Inflammation; Insulin resistance; Fasting blood glucose
ID DIABETES-MELLITUS; OXIDATIVE STRESS; AGE RESTRICTION; RISK; HEALTHY;
   FOODS; ENDPRODUCTS; GLYCOTOXINS; ACTIVATION
AB The study aimed to investigate the effects of 8-weeks AGEs restricted diet on glycemic control as well as lipid profile, inflammatory and oxidative stress biomarkers and IR in overweight patients with Mets. In this randomized, controlled clinical trial 40 clients were randomly assigned to take either a low AGE (L-AGE) or a regular AGE (Reg-AGE) diet. Also, both groups were advised to follow an energy-restricted diet. At baseline and after 8-weeks of intervention, anthropometric parameters, dietary intake, plasma concentrations of malondialdehyde, carboxymethyllysine, TNF-alpha, hs-CRP and levels of serum glucose, lipid and insulin were assessed. AGEs restriction resulted in significant changes in mean differences levels of CML (p < 0.004), FBG (p < 0.01), HOMA-IR (p < 0.04), TNF-alpha (p < 0.01) and MDA (p < 0.02) in comparison to Reg-AGE. Moreover, weight (p < 0.0001) and WC (p < 0.001) significantly declined in the intervention group. Our results indicate that dAGEs restriction plus a low-calorie diet is superior to a low-calorie diet in amelioration of central obesity and IR at least partially through reduction of OS and inflammation in Mets subjects.
C1 [Goudarzi, Razieh; Hekmatdoost, Azita; Sohrab, Golbon] Shahid Beheshti Univ Med Sci, Dept Clin Nutr & Dietet, Fac Nutr Sci & Food Technol, Natl Nutr & Food Technol Res Inst, 46 Hafezi St,Farahzadi Blvd,POB 19395-4741, Tehran, Iran.
   [Sedaghat, Meghdad] Shahid Beheshti Univ Med Sci, Dept Internal Med, Imam Hossein Hosp, Tehran, Iran.
   [Hedayati, Mehdi] Shahid Beheshti Univ Med Sci, Cellular & Mol Endocrine Res Ctr, Res Inst Endocrine Sci, Tehran, Iran.
C3 Shahid Beheshti University Medical Sciences; Shahid Beheshti University
   Medical Sciences; Shahid Beheshti University Medical Sciences
RP Sohrab, G (corresponding author), Shahid Beheshti Univ Med Sci, Dept Clin Nutr & Dietet, Fac Nutr Sci & Food Technol, Natl Nutr & Food Technol Res Inst, 46 Hafezi St,Farahzadi Blvd,POB 19395-4741, Tehran, Iran.
EM golbonsohrab@yahoo.com
RI Sohrab, Golbon/AHE-4922-2022; Hedayati, Mehdi/AAG-3006-2019;
   Hekmatdoost, Azita/AGM-6497-2022; goudarzi, razieh/J-1328-2017
OI Hekmatdoost, Azita/0000-0002-1944-0052; goudarzi,
   razieh/0000-0003-1091-7552
CR Ahima R. S, 2016, METABOLIC SYNDROME C, P3, DOI DOI 10.1007/978-3-319-11251-0_1
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NR 38
TC 16
Z9 16
U1 0
U2 7
PU SPRINGER INT PUBL AG
PI CHAM
PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND
EI 2251-6581
J9 J DIABETES METAB DIS
JI J. Diabetes Metab. Disord.
PD DEC
PY 2020
VL 19
IS 2
BP 1129
EP 1138
DI 10.1007/s40200-020-00614-0
EA AUG 2020
PG 10
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA QC8UX
UT WOS:000567565000001
PM 33520830
OA Green Published
DA 2025-06-11
ER

PT J
AU Whaley-Connell, A
   McCullough, PA
   Sowers, JR
AF Whaley-Connell, Adam
   McCullough, Peter A.
   Sowers, James R.
TI The Role of Oxidative Stress in the Metabolic Syndrome
SO REVIEWS IN CARDIOVASCULAR MEDICINE
LA English
DT Review
DE Metabolic syndrome; Oxidative stress; Labile iron; Neutrophil-associated
   lipocalin; Galectin-3
ID ANGIOTENSIN-ALDOSTERONE SYSTEM; CORONARY-HEART-DISEASE; NITRIC-OXIDE
   SYNTHASE; INSULIN-RESISTANCE; CARDIOVASCULAR-DISEASE; NAD(P)H OXIDASE;
   CLINICAL-IMPLICATIONS; INDUCED HYPERTENSION; KIDNEY-DISEASE; NADPH
   OXIDASES
AB Loss of reduction-oxidation (redox) homeostasis and generation of excess free oxygen radicals play an important role in the pathogenesis of diabetes, hypertension, and consequent cardiovascular disease. Reactive oxygen species are integral in routine in physiologic mechanisms. However, loss of redox homeostasis contributes to proinflammatory and pro fibrotic pathways that promote impairments in insulin metabolic signaling, reduced endothelial-mediated vasorelaxation, and associated cardiovascular and renal structural and functional abnormalities. Redox control of metabolic function is a dynamic process with reversible pro- and anti-free radical processes. Labile iron is necessary for the catalysis of superoxide anion, hydrogen peroxide, and the generation of the damaging hydroxyl radical. Acute hypoxia and cellular damage in cardiovascular tissue liberate larger amounts of cytosolic and extracellular iron that is poorly liganded; thus, large increases in the generation of oxygen free radicals are possible, causing tissue damage. The understanding of iron and the imbalance of redox homeostasis within the vasculature is integral in hypertension and progression of metabolic dysregulation that contributes to insulin resistance, endothelial dysfunction, and cardiovascular and kidney disease. [Rev Cardiovasc Med. 2011;12(1):21-29 doi: 10.3909/ricm0555] (C) 2011 MedReviews (R), LLC
C1 [Whaley-Connell, Adam; Sowers, James R.] Harry S Truman VA Med Ctr, Diabet & Cardiovasc Ctr, Columbia, MO 65201 USA.
   [Whaley-Connell, Adam; Sowers, James R.] Univ Missouri, Sch Med, Columbia, MO USA.
   [McCullough, Peter A.] Providence Pk Hosp, St John Providence Hlth Syst, Dept Med, Cardiol Sect, Novi, MI USA.
C3 University of Missouri System; University of Missouri Columbia; US
   Department of Veterans Affairs; Veterans Health Administration (VHA);
   Harry S. Truman Memorial Veterans' Hospital; University of Missouri
   System; University of Missouri Columbia; St. John Hospital & Medical
   Center
RP Whaley-Connell, A (corresponding author), Harry S Truman VA Med Ctr, Diabet & Cardiovasc Ctr, Columbia, MO 65201 USA.
OI Whaley-Connell, Adam/0000-0001-8955-5560
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NR 81
TC 99
Z9 115
U1 0
U2 11
PU IMR PRESS
PI WAN CHAI
PA RM 19C, LOCKHART CTR, 301-307 LOCKHART RD, WAN CHAI, 00000, HONG KONG
SN 1530-6550
EI 2153-8174
J9 REV CARDIOVASC MED
JI Rev. Cardiovasc. Med.
PY 2011
VL 12
IS 1
BP 21
EP 29
DI 10.3909/ricm0555
PG 9
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 746SM
UT WOS:000289267500003
PM 21546885
OA Bronze
DA 2025-06-11
ER

PT J
AU Nunn, AV
   Guy, GW
   Brodie, JS
   Bell, JD
AF Nunn, Alistair V.
   Guy, Geoffrey W.
   Brodie, James S.
   Bell, Jimmy D.
TI Inflammatory modulation of exercise salience: using hormesis to return
   to a healthy lifestyle
SO NUTRITION & METABOLISM
LA English
DT Article
ID SPONTANEOUS PHYSICAL-ACTIVITY; DIET-INDUCED OBESITY; C-REACTIVE PROTEIN;
   METABOLIC SYNDROME; ADIPOSE-TISSUE; VISCERAL FAT; MITOCHONDRIAL
   BIOGENESIS; CALORIE RESTRICTION; VOLUNTARY EXERCISE; SICKNESS BEHAVIOR
AB Most of the human population in the western world has access to unlimited calories and leads an increasingly sedentary lifestyle. The propensity to undertake voluntary exercise or indulge in spontaneous physical exercise, which might be termed "exercise salience", is drawing increased scientific attention. Despite its genetic aspects, this complex behaviour is clearly modulated by the environment and influenced by physiological states. Inflammation is often overlooked as one of these conditions even though it is known to induce a state of reduced mobility. Chronic subclinical inflammation is associated with the metabolic syndrome; a largely lifestyle-induced disease which can lead to decreased exercise salience. The result is a vicious cycle that increases oxidative stress and reduces metabolic flexibility and perpetuates the disease state. In contrast, hormetic stimuli can induce an anti-inflammatory phenotype, thereby enhancing exercise salience, leading to greater biological fitness and improved functional longevity. One general consequence of hormesis is upregulation of mitochondrial function and resistance to oxidative stress. Examples of hormetic factors include calorie restriction, extreme environmental temperatures, physical activity and polyphenols. The hormetic modulation of inflammation, and thus, exercise salience, may help to explain the highly heterogeneous expression of voluntary exercise behaviour and therefore body composition phenotypes of humans living in similar obesogenic environments.
C1 [Nunn, Alistair V.; Bell, Jimmy D.] Univ London Imperial Coll Sci Technol & Med, Hammersmith Hosp, MRC Clin Sci Ctr, Metab & Mol Imaging Grp, London W12 OHS, England.
   [Guy, Geoffrey W.; Brodie, James S.] GW Pharmaceut, Salisbury SP4 0JQ, Wilts, England.
C3 Imperial College London
RP Nunn, AV (corresponding author), Univ London Imperial Coll Sci Technol & Med, Hammersmith Hosp, MRC Clin Sci Ctr, Metab & Mol Imaging Grp, Du Cane Rd, London W12 OHS, England.
EM alistair.nunn@btconnect.com
RI Nunn, Alistair/ABE-2462-2020
OI Bell, Jimmy/0000-0003-3804-1281
FU GW pharmaceuticals; MRC [MC_U120061305] Funding Source: UKRI
FX To GW pharmaceuticals for financial support that enabled the development
   of the original hypothesis and the writing of the manuscript. We would
   also like to thank Andrea Nunn for help in clarifying the central ideas
   through informal discussion and Marcos Esteban Qui ones Lembach por
   inspiratio.
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NR 98
TC 27
Z9 28
U1 0
U2 9
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1743-7075
J9 NUTR METAB
JI Nutr. Metab.
PD DEC 9
PY 2010
VL 7
AR 87
DI 10.1186/1743-7075-7-87
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 698UV
UT WOS:000285619600001
PM 21143891
OA gold, Green Published, Green Accepted
DA 2025-06-11
ER

PT J
AU Camps, J
   Marsillach, J
   Joven, J
AF Camps, Jordi
   Marsillach, Judit
   Joven, Jorge
TI The paraoxonases: role in human diseases and methodological difficulties
   in measurement
SO CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES
LA English
DT Review
DE Apolipoproteins; arteriosclerosis; diabetes; high density lipoprotein;
   lactonase; lipid peroxidation; lipoproteins; liver disease; metabolic
   syndrome; method evaluation; oxidative stress; paraoxonase-1;
   paraoxonase-2; paraoxonase-3
ID HIGH-DENSITY-LIPOPROTEIN; HUMAN-SERUM PARAOXONASE; APOLIPOPROTEIN-A-I;
   CORONARY-HEART-DISEASE; ADENOVIRUS-MEDIATED EXPRESSION; REVERSE
   CHOLESTEROL TRANSPORT; PLATELET-ACTIVATING-FACTOR; ONSET
   ALZHEIMERS-DISEASE; PON1 GENE POLYMORPHISMS; OXIDATIVE STRESS
AB Research into the paraoxonase (PON) gene family has flourished over the past few years. In the 1970s and 1980s, only PON1 was known, and the investigations were conducted, essentially, by toxicologists focusing on protection against organophosphate poisoning. Since then, two new members of the family, PON2 and PON3, have been identified, both being shown to play antioxidant and anti-inflammatory roles. Evidence exists indicating that the PON family is central to a wide variety of human illnesses such as cardiovascular disease, diabetes mellitus, metabolic syndrome, obesity, non-alcoholic steatohepatitis, and several mental disorders. However, research is hampered considerably by the methods currently available to measure the activity of these enzymes. In this review, we summarize the state of knowledge on PON biochemistry and function, the influence of genetic variations, and the involvement of PON in several diseases. The problems associated with PON measurement, such as sample acquisition, lack of reference methods, and variety of substrates, will be presented. Also, we cover some of the present lines of research and propose some others for future progress in this field.
C1 [Camps, Jordi; Marsillach, Judit; Joven, Jorge] Univ Rovira & Virgili, Hosp Univ St Joan, Ctr Rec Biomed, Inst Invest Sanitaria Pere Virgili, Reus 43201, Spain.
C3 Universitat Rovira i Virgili; Institut d'Investigacio Sanitaria Pere
   Virgili (IISPV)
RP Camps, J (corresponding author), Univ Rovira & Virgili, Hosp Univ St Joan, Ctr Rec Biomed, Inst Invest Sanitaria Pere Virgili, C St Joan S-N, Reus 43201, Spain.
EM jcamps@grupsagessa.cat
RI Camps, Jordi/AAG-3080-2020; Marsillach, Judit/I-1329-2015; Joven,
   Jorge/B-3360-2016
OI Joven, Jorge/0000-0003-2749-4541
FU Instituto de Salud Carlos III [FIS 02/0430, 04/1752, 05/1607, RCMN
   C03/08, RD06]; Ministerio de Sanidad, Madrid, Spain; Generalitat de
   Catalunya [FI 05/00068]
FX The authors of this manuscript belong to the Working Group on Markers of
   Oxidative Stress and Inflammation of the Spanish Society of Clinical
   Chemistry and Molecular Pathology. Some studies described in this
   article have been funded by grants from the Instituto de Salud Carlos
   III (FIS 02/0430, 04/1752, 05/1607, RCMN C03/08, and RD06), Ministerio
   de Sanidad, Madrid, Spain. J. M. is the recipient of a post-graduate
   fellowship from the Generalitat de Catalunya (FI 05/00068).
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NR 255
TC 221
Z9 236
U1 0
U2 20
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1040-8363
EI 1549-781X
J9 CRIT REV CL LAB SCI
JI Crit. Rev. Clin. Lab. Sci.
PY 2009
VL 46
IS 2
BP 83
EP 106
AR PII 909183322
DI 10.1080/10408360802610878
PG 24
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA 413TC
UT WOS:000263814400002
PM 19255916
DA 2025-06-11
ER

PT J
AU Liao, D
   Mo, L
   Chen, M
AF Liao, Diying
   Mo, Lili
   Chen, Maowei
TI The Effectiveness of Dance Interventions on Health-Related Outcomes in
   Perimenopausal, Menopausal, and Postmenopausal Women: A Systematic
   Review and Meta-Analysis
SO HEALTHCARE
LA English
DT Review
DE dance intervention; health-related outcomes; meta-analysis; menopausal
   symptoms; systematic review; women
ID METABOLIC SYNDROME; THERAPY; BENEFITS; BIAS
AB Background/Objectives: Dance intervention, as a non-pharmacological therapy, has shown promising potential in alleviating menopausal symptoms among perimenopausal, menopausal, and postmenopausal women. However, a systematic evaluation of its overall effectiveness based on existing trials remains unavailable. This study aims to investigate the effectiveness of dance intervention on health-related outcomes in perimenopausal, menopausal, and postmenopausal women through a systematic review and meta-analysis. Methods: This study systematically searched the relevant databases on 18 October 2024. The risk of bias was assessed using the Cochrane RoB 2 and ROBINS-I tools. Meta-analysis was performed using Review Manager version 5.4. software. For results unsuitable for meta-analysis, narrative synthesis was conducted. The study was registered in PROSPERO (number: CRD42024613134). Results: Meta-analysis demonstrated significant positive effects of dance intervention on psychological symptoms, including depression (I-2 = 87%, p < 0.001), anxiety (I-2 = 90%, p = 0.01), vitality (I-2 = 0%, p = 0.03), interpersonal relationships (I-2 = 0%, p < 0.001), and somatization (I-2 = 85%, p = 0.01), in menopausal women, but no significant impact was observed on psychotic symptoms (I-2 = 89%, p = 0.33). However, the high heterogeneity suggests the presence of potential confounding factors among studies. Sensitivity analysis indicated that the flexibility of the intervention protocol and intra-group differences among participants may have been the main sources of heterogeneity. Further subgroup analysis revealed that interventions conducted less than three times per week had significant effects on depressive symptoms (SMD = -1.93), while a total intervention duration of <= 1800 min significantly improved anxiety symptoms (SMD = -2.15). Conclusions: Dance interventions have significant positive effects on health-related outcomes in perimenopausal, menopausal, and postmenopausal women, except for psychotic symptoms, offering a promising intervention option for clinical practice.
C1 [Liao, Diying; Mo, Lili] Kangwon Natl Univ, Grad Sch Global Convergence, Chunchon 24341, South Korea.
   [Chen, Maowei] Kangwon Natl Univ, Dept Global Convergence, Chunchon 24341, South Korea.
C3 Kangwon National University; Kangwon National University
RP Chen, M (corresponding author), Kangwon Natl Univ, Dept Global Convergence, Chunchon 24341, South Korea.
EM ldy9074532748@163.com; m17307149375@163.com; muwi@kangwon.ac.kr
RI Chen, Maowei/IXW-6804-2023
OI Mo, Lili/0009-0007-7718-2948; Chen, Maowei/0000-0002-7398-4368
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NR 60
TC 0
Z9 0
U1 2
U2 2
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2227-9032
J9 HEALTHCARE-BASEL
JI Healthcare
PD APR 11
PY 2025
VL 13
IS 8
AR 881
DI 10.3390/healthcare13080881
PG 22
WC Health Care Sciences & Services; Health Policy & Services
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services
GA 1XP0R
UT WOS:001476051100001
PM 40281829
DA 2025-06-11
ER

PT J
AU Vargas, EA
   Patel, RB
   Medina-Lezama, J
   Chirinos, DA
AF Vargas, Emily A.
   Patel, Ravi B.
   Medina-Lezama, Josefina
   Chirinos, Diana A.
TI Depressive Symptoms Are Associated with Reduced Cardiac Function Among
   Hispanics: Results from the PREVENCION Study
SO INTERNATIONAL JOURNAL OF BEHAVIORAL MEDICINE
LA English
DT Article
DE Depressive symptoms; Cardiac function; Impedance cardiography; Heart
   failure; South American Hispanics
ID PERUVIAN ANDEAN HISPANICS; HEART-FAILURE PATIENTS; METABOLIC SYNDROME;
   HOSPITAL ANXIETY; HEALTH-STATUS; RISK; PREVALENCE; HYPERTENSION;
   DYSFUNCTION; PREDICTORS
AB Background Depressive symptoms are common among patients with heart failure and are often associated with adverse outcomes, including re-hospitalization and mortality. However, little is known about the association between depressive symptoms and subclinical markers of heart failure and cardiac function in community-based samples and little research has focused on South American Hispanics. The current study examined the cross-sectional association between depressive symptoms and cardiac function in South American Hispanic community-based adults. Methods Participants included 527 adults enrolled in the Peruvian Study of Cardiovascular Disease (PREVENCION). Depressive symptoms were assessed with the Hospital Anxiety and Depression Scale (HADS). Markers of cardiac function were assessed by impedance cardiography and included cardiac output, cardiac index, stroke volume, and stroke volume index. Several multiple regression analyses were used to examine the association between depressive symptoms and markers of cardiac function. Results In adjusted analyses, depressive symptoms were associated with reduced cardiac output, cardiac index, stroke volume, and stroke volume index. These associations remained significant between depressive symptoms and cardiac output (beta = - 0.106, p = 0.014), cardiac index (beta = - 0.099, p = 0.029), and stroke volume (beta = - 0.095, p = 0.022), and a trend was still observed between depressive symptoms and stroke index (beta = - 0.083, p = 0.061), even after having controlled for demographic factors (age, gender, education), cardiovascular risk factors (smoking status, body mass index, low- and high-density lipoprotein cholesterol, triglycerides, fasting glucose, serum creatinine), and comorbidities (diabetes mellitus, hypertension, hypercholesterolemia). Conclusions In the PREVENCION sample tested, depressive symptoms were independently associated with cardiac function among Hispanic adults, even above and beyond pertinent factors such as demographic factors, cardiovascular risk factors, and comorbidities. Future studies should determine whether depressive symptoms are prospectively associated with systolic dysfunction, and examine the bio-behavioral pathways of this association.
C1 [Vargas, Emily A.; Patel, Ravi B.; Chirinos, Diana A.] Northwestern Univ, Feinberg Sch Med, Dept Prevent Med, 680 Lake Shore Dr, Chicago, IL 60611 USA.
   [Medina-Lezama, Josefina] Santa Maria Catholic Univ, Res Inst, Arequipa, Peru.
C3 Northwestern University; Feinberg School of Medicine; Universidad
   Catolica de Santa Maria
RP Vargas, EA (corresponding author), Northwestern Univ, Feinberg Sch Med, Dept Prevent Med, 680 Lake Shore Dr, Chicago, IL 60611 USA.
EM emily.vargas1@northwestern.edu
RI Patel, Ravi/LCE-3709-2024
OI , Dr. Ravi Patel/0009-0007-6033-2671
FU T32 Research Training Program in Cardiovascular Disease Epidemiology and
   Prevention at Northwestern University, Department of Preventive Medicine
FX EAV and RBP are funded by the T32 Research Training Program in
   Cardiovascular Disease Epidemiology and Prevention at Northwestern
   University, Department of Preventive Medicine.
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NR 48
TC 1
Z9 1
U1 0
U2 6
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1070-5503
EI 1532-7558
J9 INT J BEHAV MED
JI Int. J. Behav. Med.
PD OCT
PY 2021
VL 28
IS 5
BP 531
EP 539
DI 10.1007/s12529-020-09941-1
EA NOV 2020
PG 9
WC Psychology, Clinical
WE Social Science Citation Index (SSCI)
SC Psychology
GA UE6IW
UT WOS:000588232300004
PM 33170471
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Desai, P
   Donovan, L
   Janowitz, E
   Kim, JY
AF Desai, Priya
   Donovan, Lorin
   Janowitz, Elizabeth
   Kim, Joon Young
TI The Clinical Utility of Salivary Biomarkers in the Identification of
   Type 2 Diabetes Risk and Metabolic Syndrome
SO DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
LA English
DT Review
DE saliva; inflammation; type 2 diabetes; biomarkers; metabolic syndrome;
   oxidative stress
ID C-REACTIVE PROTEIN; SERUM 1,5-ANHYDROGLUCITOL CONCENTRATIONS; 1,5
   ANHYDROGLUCITOL LEVELS; ADIPOSE-SPECIFIC PROTEIN; NECROSIS-FACTOR-ALPHA;
   INSULIN-RESISTANCE; PLASMA ADIPONECTIN; OXIDATIVE STRESS; GLYCEMIC
   CONTROL; LEPTIN LEVELS
AB Type 2 diabetes is traditionally diagnosed by the use of an oral glucose tolerance test and/or HbA1c, both of which require serum collection. Various biomarkers, which are measurable biological substances that provide clinical insight on disease state, have also been effective in the early identification and risk prediction of inflammatory diseases. Measuring biomarker concentrations has traditionally been obtained through serum collection as well. However, numerous biomarkers are detectable in saliva. Salivary analysis has more recently been introduced into research as a potential non-invasive, cost-effective diagnostic for the early identification of type 2 diabetes risk in adults and youth. Therefore, the purpose of this review was to compare 6 established inflammatory biomarkers of type 2 diabetes, in serum and saliva, and determine if similar diagnostic effectiveness is seen in saliva. A lack of standardized salivary analysis, processing, and collection accounts for errors and inconsistencies in conclusive data amongst studies. Proposing a national standardization in salivary analysis, coupled with increased data and research on the utility of saliva as a diagnostic, poses the potential for salivary analysis to be used in diagnostic settings.
C1 [Desai, Priya; Donovan, Lorin; Janowitz, Elizabeth; Kim, Joon Young] Syracuse Univ, Dept Exercise Sci, Womens Bldg 204E,820 Comstock Ave, Syracuse, NY 13244 USA.
C3 Syracuse University
RP Kim, JY (corresponding author), Syracuse Univ, Dept Exercise Sci, Womens Bldg 204E,820 Comstock Ave, Syracuse, NY 13244 USA.
EM jkim291@syr.edu
RI Kim, Joon/I-9690-2016
OI Desai, Priya/0000-0002-0562-2242; Kim, Joon Young/0000-0003-0448-1684
FU Department of Exercise Science at Syracuse University
FX This work was supported by the Department of Exercise Science at
   Syracuse University.
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NR 99
TC 12
Z9 12
U1 0
U2 16
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-7007
J9 DIABET METAB SYND OB
JI Diabetes Metab. Syndr. Obes.
PY 2020
VL 13
BP 3587
EP 3599
DI 10.2147/DMSO.S265879
PG 13
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA OD3QF
UT WOS:000579766700002
PM 33116710
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Guimbaud, JB
   Siskos, AP
   Sakhi, AK
   Heude, B
   Sabidó, E
   Borràs, E
   Keun, H
   Wright, J
   Julvez, J
   Urquiza, J
   Gützkow, KB
   Chatzi, L
   Casas, M
   Bustamante, M
   Nieuwenhuijsen, M
   Vrijheid, M
   López-Vicente, M
   Pascual, MD
   Stratakis, N
   Robinson, O
   Grazuleviciene, R
   Slama, R
   Alemany, S
   Basagaña, X
   Plantevit, M
   Cazabet, R
   Maitre, L
AF Guimbaud, Jean-Baptiste
   Siskos, Alexandros P.
   Sakhi, Amrit Kaur
   Heude, Barbara
   Sabido, Eduard
   Borras, Eva
   Keun, Hector
   Wright, John
   Julvez, Jordi
   Urquiza, Jose
   Gutzkow, Kristine Bjerve
   Chatzi, Leda
   Casas, Maribel
   Bustamante, Mariona
   Nieuwenhuijsen, Mark
   Vrijheid, Martine
   Lopez-Vicente, Monica
   Pascual, Montserrat de Castro
   Stratakis, Nikos
   Robinson, Oliver
   Grazuleviciene, Regina
   Slama, Remy
   Alemany, Silvia
   Basagana, Xavier
   Plantevit, Marc
   Cazabet, Remy
   Maitre, Lea
TI Machine learning-based health environmental-clinical risk scores in
   European children
SO COMMUNICATIONS MEDICINE
LA English
DT Article
ID COHORT PROFILE; MENTAL-HEALTH; CHILDHOOD; EXPOSURE; OBESITY; EXPOSOME;
   OUTCOMES; DISEASE; MOTHER; GENOME
AB Background Early life environmental stressors play an important role in the development of multiple chronic disorders. Previous studies that used environmental risk scores (ERS) to assess the cumulative impact of environmental exposures on health are limited by the diversity of exposures included, especially for early life determinants. We used machine learning methods to build early life exposome risk scores for three health outcomes using environmental, molecular, and clinical data.Methods In this study, we analyzed data from 1622 mother-child pairs from the HELIX European birth cohorts, using over 300 environmental, 100 child peripheral, and 18 mother-child clinical markers to compute environmental-clinical risk scores (ECRS) for child behavioral difficulties, metabolic syndrome, and lung function. ECRS were computed using LASSO, Random Forest and XGBoost. XGBoost ECRS were selected to extract local feature contributions using Shapley values and derive feature importance and interactions.Results ECRS captured 13%, 50% and 4% of the variance in mental, cardiometabolic, and respiratory health, respectively. We observed no significant differences in predictive performances between the above-mentioned methods.The most important predictive features were maternal stress, noise, and lifestyle exposures for mental health; proteome (mainly IL1B) and metabolome features for cardiometabolic health; child BMI and urine metabolites for respiratory health.Conclusions Besides their usefulness for epidemiological research, our risk scores show great potential to capture holistic individual level non-hereditary risk associations that can inform practitioners about actionable factors of high-risk children. As in the post-genetic era personalized prevention medicine will focus more and more on modifiable factors, we believe that such integrative approaches will be instrumental in shaping future healthcare paradigms.
   Growing up in different environments can greatly affect children's health later in life. This research looked at how living in cities, being exposed to chemicals, and other experiences before birth and during childhood, work together to influence children's mental, cardiovascular and respiratory health. We used advanced computer programs to help us understand these effects and estimate health risk scores. These scores are simple numerical measures that help us quantify the likelihood of children developing health issues based on their environmental exposures. Using those scores, the study identified key factors impacting children's health, in particular psycho-social, perceived environmental and prenatal pollutant exposures for mental health. It also revealed complex patterns and interactions between environmental factors. The results highlighted the potential of such risk scores to support the identification of actionable factors in high-risk children, informing tailored prevention measures in healthcare.
   Guimbaud et al. use machine learning in a dataset of 1600 European mother-child pairs to link early-life environmental exposures with children's health. Through the computation of environmental-clinical risk scores, they unveil complex interactions and nonlinear patterns among these factors, underscoring their intricate role in children's health.
C1 [Guimbaud, Jean-Baptiste; Julvez, Jordi; Urquiza, Jose; Casas, Maribel; Bustamante, Mariona; Nieuwenhuijsen, Mark; Vrijheid, Martine; Lopez-Vicente, Monica; Pascual, Montserrat de Castro; Basagana, Xavier; Maitre, Lea] ISGlobal, Barcelona, Spain.
   [Guimbaud, Jean-Baptiste; Cazabet, Remy] Univ Lyon, CNRS, INSA Lyon, UCBL,LIRIS,UMR5205, F-69622 Villeurbanne, France.
   [Guimbaud, Jean-Baptiste; Sabido, Eduard; Borras, Eva; Urquiza, Jose; Casas, Maribel; Bustamante, Mariona; Vrijheid, Martine; Lopez-Vicente, Monica; Pascual, Montserrat de Castro; Basagana, Xavier; Maitre, Lea] Univ Pompeu Fabra UPF, Barcelona, Spain.
   [Guimbaud, Jean-Baptiste] Meersens, Lyon, France.
   [Siskos, Alexandros P.; Keun, Hector] Imperial Coll London, Dept Surg & Canc, Div Canc, Canc Metab & Syst Toxicol Grp, London, England.
   [Sakhi, Amrit Kaur; Gutzkow, Kristine Bjerve] Norwegian Inst Publ Hlth, Oslo, Norway.
   [Heude, Barbara] Univ Paris Cite, Ctr Res Epidemiol & Stat CRESS, Inserm, INRAE, Paris, France.
   [Sabido, Eduard; Borras, Eva] Barcelona Inst Sci & Technol BIST, Ctr Regulacio Genom, Barcelona, Spain.
   [Wright, John] Bradford Inst Hlth Res, Bradford, England.
   [Wright, John] Bradford Teaching Hosp NHS Fdn Trust, Bradford, England.
   [Julvez, Jordi; Urquiza, Jose; Casas, Maribel; Bustamante, Mariona; Vrijheid, Martine; Lopez-Vicente, Monica; Pascual, Montserrat de Castro; Basagana, Xavier; Maitre, Lea] CIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain.
   [Julvez, Jordi] Hosp Univ St Joan Reus, Inst Invest Sanitaria Pere Virgili, Reus, Spain.
   [Chatzi, Leda; Stratakis, Nikos] Univ Southern Calif, Dept Prevent Med, Los Angeles, CA USA.
   [Robinson, Oliver] Imperial Coll London, Ctr Environm & Hlth, Sch Publ Hlth, ed Res Council, London, England.
   [Robinson, Oliver] Imperial Coll London, Mohn Ctr Childrens Hlth & Well being, Sch Publ Hlth, London, England.
   [Grazuleviciene, Regina] Vytautas Magnus Univ, Dept Environm Sci, Kaunas, Lithuania.
   [Slama, Remy] Univ Grenoble Alpes, Inst Adv Biosci, CHU Grenoble Alpes, Inserm,CNRS,Team Environm Epidemiol, Grenoble, France.
   [Alemany, Silvia] Univ Autonoma Barcelona, Vall dHebron Res Inst VHIR, Psychiat Genet Unit, Grp Psychiat Mental Hlth & Addict, Barcelona, Spain.
   [Alemany, Silvia] Hosp Univ Vall dHebron, Dept Mental Hlth, Barcelona, Spain.
   [Alemany, Silvia] Biomed Network Res Ctr Mental Hlth CIBERSAM, Inst Salud Carlos III, Madrid, Spain.
   [Plantevit, Marc] EPITA Res Lab LRE, Le Kremlin Bicetre, France.
C3 ISGlobal; Centre National de la Recherche Scientifique (CNRS); CNRS -
   Institute for Information Sciences & Technologies (INS2I); Institut
   National des Sciences Appliquees de Lyon - INSA Lyon; Universite Claude
   Bernard Lyon 1; Pompeu Fabra University; Imperial College London;
   Norwegian Institute of Public Health (NIPH); Institut National de la
   Sante et de la Recherche Medicale (Inserm); INRAE; Universite Paris
   Cite; Barcelona Institute of Science & Technology; Pompeu Fabra
   University; Centre de Regulacio Genomica (CRG); CIBER - Centro de
   Investigacion Biomedica en Red; CIBERESP; Universitat Rovira i Virgili;
   Institut d'Investigacio Sanitaria Pere Virgili (IISPV); University of
   Southern California; Imperial College London; Imperial College London;
   Vytautas Magnus University; CHU Grenoble Alpes; Centre National de la
   Recherche Scientifique (CNRS); Communaute Universite Grenoble Alpes;
   Universite Grenoble Alpes (UGA); Institut National de la Sante et de la
   Recherche Medicale (Inserm); Autonomous University of Barcelona;
   Hospital Universitari Vall d'Hebron; Vall d'Hebron Institut de Recerca
   (VHIR); Hospital Universitari Vall d'Hebron; CIBER - Centro de
   Investigacion Biomedica en Red; CIBERSAM; Instituto de Salud Carlos III
RP Maitre, L (corresponding author), ISGlobal, Barcelona, Spain.; Maitre, L (corresponding author), Univ Pompeu Fabra UPF, Barcelona, Spain.; Maitre, L (corresponding author), CIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain.
EM lea.maitre@isglobal.org
RI Heude, Barbara/G-3095-2016; Casas, Maribel/T-5643-2017; Vrijheid,
   Martine/H-2702-2014; Bustamante, Mariona/ABB-9142-2021; Cazabet,
   Remy/T-7028-2019; Grazuleviciene, Regina/AAR-4539-2021; Sabidó,
   Eduard/F-7914-2015; de Castro, Montserrat/ABF-8902-2020; Basagaña,
   Xavier/C-3901-2017; Stratakis, Nikos/AFV-3674-2022; Maitre,
   Léa/Y-1726-2019; Alemany, Silvia/J-7419-2013; Julvez, Jordi/R-4531-2017;
   Urquiza Ortiz, Jose Miguel/E-2446-2018; Wright, John/H-1624-2012
OI Alemany, Silvia/0000-0002-7925-6767; Stratakis, Nikolaos
   (Nikos)/0000-0003-4613-0989; Julvez, Jordi/0000-0003-0818-4003; Urquiza
   Ortiz, Jose Miguel/0000-0003-2220-607X; Guimbaud,
   Jean-Baptiste/0000-0003-3748-1453; Wright, John/0000-0001-9572-7293
FU Norwegian Ministry of Health and Care Services; Ministry of Education
   and Research; Spanish Ministry of Science and Innovation to the EMBL;
   Centro de Excelencia Severo Ochoa; CERCA Programme / Generalitat de
   Catalunya [ICTS OmicsTech]; Secretaria d'Universitats i Recerca del
   Departament d'Economia i Coneixement de la Generalitat de Catalunya
   [2021SGR01225, 2021SGR01563, H2020-EU.3.1.2, 874583]; CIFRE PhD
   fellowship [2020/1297]; Juan de la Cierva-Incorporacin fellowship
   [IJC2020-045355-I, MCIN/AEI/10.13039/501100011033]; Spanish Ministerio
   de Economa, Industria y Competitividad; Spanish Ministry of Science and
   Innovation through the "Centro de Excelencia Severo Ochoa [2019-2023,
   CEX2018-000806-S]; Generalitat de Catalunya through the CERCA Program;
   Catalan program PERIS [SLT017/20/000119]; Departament de Salut de la
   Generalitat de Catalunya (Spain) - UK Research and Innovation Future
   Leaders Fellowship [MR/S03532X/1, CP22/00026]; Instituto de Salud Carlos
   III - European Union Found: Fondo Social Europeo Plus; European
   Community;  [308333]
FX The authors would like to thank all the participating children, parents,
   practitioners, and researchers in the six countries who took part in
   this study. The Norwegian Mother, Father and Child Cohort Study is
   supported by the Norwegian Ministry of Health and Care Services and the
   Ministry of Education and Research. We also acknowledge the support of
   the Spanish Ministry of Science and Innovation to the EMBL partnership,
   the Centro de Excelencia Severo Ochoa, and the CERCA Programme /
   Generalitat de Catalunya. The CRG/UPF Proteomics Unit is part of the
   Spanish Infrastructure for Omics Technologies (ICTS OmicsTech) and it is
   supported by "Secretaria d'Universitats i Recerca del Departament
   d'Economia i Coneixement de la Generalitat de Catalunya" (2021SGR01225
   and 2021SGR01563). This project was funded by the
   H2020-EU.3.1.2.-Preventing Disease Programme under grant agreement no
   874583 (ATHLETE project). JB Guimbaud was supported by a CIFRE PhD
   fellowship (#2020/1297). Lea Maitre is funded by a Juan de la
   Cierva-Incorporacion fellowship (IJC2018-035394-I) awarded by the
   Spanish Ministerio de Economia, Industria y Competitividad. ISGlobal and
   the Exposome hub acknowledges support from the Spanish Ministry of
   Science and Innovation through the "Centro de Excelencia Severo Ochoa
   2019-2023" Program (CEX2018-000806-S), and support from the Generalitat
   de Catalunya through the CERCA Program. Jose Urquiza is supported by
   Catalan program PERIS (Ref.: SLT017/20/000119), granted by Departament
   de Salut de la Generalitat de Catalunya (Spain). Oliver Robinson was
   funded by the UK Research and Innovation Future Leaders Fellowship
   (MR/S03532X/1). Silvia Alemany holds a Miquel Servet-I contract
   (CP22/00026) awarded by the Instituto de Salud Carlos III co-funded by
   the European Union Found: Fondo Social Europeo Plus, FSE + . Monica
   Lopez-Vicente is funded by a Juan de la Cierva-Incorporacion fellowship
   (project IJC2020-045355-I, funded by MCIN/AEI/10.13039/501100011033 and
   for the European Union NextGenerationEU/PRTR). The data of the cohorts
   (BiB, EDEN, INMA, KANC, MoBa and RHEA) provided to this research leading
   to these results has received funding from the European Community's
   Seventh Framework Programme (FP7/2007-2013) under grant agreement no
   308333-the HELIX project. Fig. 2 was created with BioRender.com.
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NR 75
TC 4
Z9 5
U1 2
U2 15
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 2730-664X
J9 COMMUN MED-LONDON
JI Communications Med.
PD MAY 23
PY 2024
VL 4
IS 1
AR 98
DI 10.1038/s43856-024-00513-y
PG 14
WC Medicine, Research & Experimental
WE Emerging Sources Citation Index (ESCI)
SC Research & Experimental Medicine
GA RU6T4
UT WOS:001230220700002
PM 38783062
OA gold
DA 2025-06-11
ER

PT J
AU Song, IS
   Ki, EY
   Han, K
   Ryu, JJ
   Park, JB
AF Song, In-Seok
   Ki, Eun Young
   Han, Kyungdo
   Ryu, Jae-Jun
   Park, Jun-Beom
TI Evaluation of the Association between Menstrual Cycle Irregularity and
   Dental Pain or Chewing Discomfort in Women before Menopause
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Article
DE epidemiology; mastication; menstrual cycle; nutrition surveys; oral
   health; toothache
ID METABOLIC SYNDROME; NATIONAL-HEALTH; ORAL-HEALTH; OBESITY; STRESS;
   TESTOSTERONE; VALIDITY; CARIES; RISK; DHEA
AB This study was performed to assess the relationship between menstrual irregularity and dental pain or chewing discomfort in women before menopause, using nationally representative data. This study analyzed 4595 participants who were 19 years or older, and did not have missing values for outcome variables from the Korean National Health and Nutrition Examination Survey. Tooth pain was considered present if the participant felt throbbing discomfort, pain, or sensitivity when eating hot or cold food or drinking hot or cold beverages. Self-reported oral chewing discomfort was obtained. Adjusted odds ratios and their 95% confidence intervals for tooth pain in the individuals with menstrual cycle irregularity were 1.30 (1.05, 1.62) after adjustment for age, body mass index, drinking, smoking, income, exercise, stress, metabolic syndrome, and the frequency of tooth brushing. Adjusted odds ratios and their 95% confidence intervals for chewing discomfort in the individuals with menstrual cycle irregularity were 1.33 (1.03, 1.72) after adjustment. The association between menstrual irregularity and dental pain or chewing discomfort in women before menopause was provenafter adjusting for confounding factorsby multiple logistic regression analyses. Menstrual cycle irregularity may be considered a potential risk indicator for dental pain or chewing discomfort in Korean women before menopause.
C1 [Song, In-Seok] Korea Univ, Anam Hosp, Dept Oral & Maxillofacial Surg, Seoul 02841, South Korea.
   [Ki, Eun Young] Catholic Univ Korea, Coll Med, Dept Obstet & Gynecol, Seoul 06591, South Korea.
   [Han, Kyungdo] Catholic Univ Korea, Coll Med, Dept Biostat, Seoul 06591, South Korea.
   [Ryu, Jae-Jun] Korea Univ, Anam Hosp, Dept Prosthodont, Seoul 02841, South Korea.
   [Park, Jun-Beom] Catholic Univ Korea, Coll Med, Dept Periodont, Seoul 06591, South Korea.
C3 Korea University; Korea University Medicine (KU Medicine); Catholic
   University of Korea; Catholic University of Korea; Korea University;
   Korea University Medicine (KU Medicine); Catholic University of Korea
RP Park, JB (corresponding author), Catholic Univ Korea, Coll Med, Dept Periodont, Seoul 06591, South Korea.
EM sis80@naver.com; mdkey@catholic.ac.kr; hkd917@naver.com;
   koprosth@gmail.com; jbassoonis@yahoo.co.kr
RI Park, Jun-Beom/I-8201-2019; Ryu, Jae-Jun/AAL-6362-2020; Song,
   In-Seok/T-7903-2017
OI Song, In-Seok/0000-0002-0763-8838; Park, Jun-Beom/0000-0002-8915-1555
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NR 36
TC 3
Z9 3
U1 1
U2 18
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD APR
PY 2019
VL 8
IS 4
AR 454
DI 10.3390/jcm8040454
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA HX6FT
UT WOS:000467500200039
PM 30987369
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Marek, G
   Pannu, V
   Shanmugham, P
   Pancione, B
   Mascia, D
   Crosson, S
   Ishimoto, T
   Sautin, YY
AF Marek, George
   Pannu, Varinderpal
   Shanmugham, Prashanth
   Pancione, Brianna
   Mascia, Dominic
   Crosson, Sean
   Ishimoto, Takuji
   Sautin, Yuri Y.
TI Adiponectin Resistance and Proinflammatory Changes in the Visceral
   Adipose Tissue Induced by Fructose Consumption via
   Ketohexokinase-Dependent Pathway
SO DIABETES
LA English
DT Article
ID ENDOPLASMIC-RETICULUM STRESS; ACTIVATED PROTEIN-KINASE; METABOLIC
   SYNDROME; INSULIN-RESISTANCE; DIETARY FRUCTOSE; URIC-ACID; OBESITY;
   GLUCOSE; INFLAMMATION; BEVERAGES
AB An epidemic of obesity and type 2 diabetes is linked with the increase in consumption of fructose-containing sugars, such as sucrose and high-fructose corn syrup. In mammalian cells, fructose is metabolized predominantly via phosphorylation to fructose-1 phosphate by ketohexokinase (KHK) or by alternative pathways. Here we demonstrate that a KHK-dependent pathway mediates insulin resistance and inflammatory changes in the visceral fat in response to high fructose. We used mice (males, C57BL/6 background) including littermate wildtype control and mice lacking both isoforms of KHK (KHK-null). Fructose diet induced metabolic syndrome, including visceral obesity, insulin resistance, proinflammatory changes in the visceral fat (production of proinflammatory adipokines and macrophage infiltration), the endoplasmic reticulum stress signaling, and decrease of the high-molecular weight adiponectin followed by decrease in the downstream signaling. KHK-KO mice consuming the same high-fructose diet remained lean, with normal insulin sensitivity and healthy visceral adipose tissue with normal adiponectin function not distinguishable from the control by any of the tested parameters. This study demonstrates that blocking KHK and redirecting fructose metabolism to alternative pathways is an effective way to prevent visceral obesity and insulin resistance induced by high fructose, a widespread component of Western diets.
C1 [Marek, George; Pannu, Varinderpal; Shanmugham, Prashanth; Pancione, Brianna; Mascia, Dominic; Crosson, Sean; Sautin, Yuri Y.] Univ Florida, Dept Med, Gainesville, FL 32611 USA.
   [Ishimoto, Takuji] Univ Colorado, Dept Med, Denver, CO USA.
C3 State University System of Florida; University of Florida; University of
   Colorado System; University of Colorado Denver; University of Colorado
   Anschutz Medical Campus
RP Sautin, YY (corresponding author), Univ Florida, Dept Med, Gainesville, FL 32611 USA.
EM yuri.sautin@medicine.ufl.edu
RI Ishimoto, Takuji/M-4873-2014
OI Ishimoto, Takuji/0000-0002-9861-5331; Sautin, Yuri/0000-0003-3618-5134
FU American Diabetes Association [7-12-BS-162]; Gatorade Funds
FX This work was supported by the American Diabetes Association grant
   7-12-BS-162 (to Y.Y.S.) and by Gatorade Funds.
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NR 46
TC 43
Z9 46
U1 0
U2 21
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0012-1797
EI 1939-327X
J9 DIABETES
JI Diabetes
PD FEB
PY 2015
VL 64
IS 2
BP 508
EP 518
DI 10.2337/db14-0411
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA CA3ST
UT WOS:000348827100021
PM 25187370
OA Bronze
DA 2025-06-11
ER

PT J
AU Geiker, NRW
   Astrup, A
   Hjorth, MF
   Sjödin, A
   Pijls, L
   Markus, CR
AF Geiker, N. R. W.
   Astrup, A.
   Hjorth, M. F.
   Sjodin, A.
   Pijls, L.
   Markus, C. Rob
TI Does stress influence sleep patterns, food intake, weight gain,
   abdominal obesity and weight loss interventions and vice versa?
SO OBESITY REVIEWS
LA English
DT Review
DE Cortisol; cravings; sleep; visceral obesity
ID PITUITARY-ADRENAL AXIS; TERM CORTISOL-LEVELS; BODY-MASS INDEX; LIFE
   EVENTS; PSYCHOSOCIAL STRESS; COGNITIVE PERFORMANCE; WAIST CIRCUMFERENCE;
   METABOLIC SYNDROME; 5-HTTLPR GENOTYPE; CIRCADIAN-RHYTHM
AB Decades of research have reported only weak associations between the intakes of specific foods or drinks and weight gain and obesity. Randomized controlled dietary intervention trials have only shown very modest effects of changes in nutrient intake and diet composition on body weight in obese subjects. This review summarizes the scientific evidence on the role mental stress (either in or not in association with impaired sleep) may play in poor sleep, enhanced appetite, cravings and decreased motivation for physical activity. All these factors contribute to weight gain and obesity, possibly via decreasing the efficacy of weight loss interventions. We also review evidence for the role that lifestyle and stress management may play in achieving weight loss in stress-vulnerable individuals with overweight.
C1 [Geiker, N. R. W.] Copenhagen Univ Hosp Herlev & Gentofte, Clin Nutr Res Unit, Kildegardsvej 28, DK-2900 Hellerup, Denmark.
   [Astrup, A.; Hjorth, M. F.; Sjodin, A.] Univ Copenhagen, Fac Sci, Dept Nutr Exercise & Sports, Copenhagen, Denmark.
   [Pijls, L.] Loekintofood Gcv Scs, Brussels, Belgium.
   [Markus, C. Rob] Maastricht Univ, Fac Psychol & Neurosci, Neuropsychol & Psychopharmacol, Maastricht, Netherlands.
C3 University of Copenhagen; Maastricht University
RP Geiker, NRW (corresponding author), Copenhagen Univ Hosp Herlev & Gentofte, Clin Nutr Res Unit, Kildegardsvej 28, DK-2900 Hellerup, Denmark.
EM nina.rica.wium.geiker@regionh.dk
RI Geiker, Nina/GLR-2718-2022; Hjorth, Mads/A-1760-2015; Astrup,
   Arne/HZL-1679-2023; Sjödin, Anders/B-6975-2015
OI Geiker, Nina Rica Wium/0000-0001-8063-5820
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NR 130
TC 170
Z9 184
U1 1
U2 56
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1467-7881
EI 1467-789X
J9 OBES REV
JI Obes. Rev.
PD JAN
PY 2018
VL 19
IS 1
BP 81
EP 97
DI 10.1111/obr.12603
PG 17
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism
GA FO8HO
UT WOS:000417126400007
PM 28849612
DA 2025-06-11
ER

PT J
AU Hamer, M
   Boutcher, YN
   Boutcher, SH
AF Hamer, Mark
   Boutcher, Yati N.
   Boutcher, Stephen H.
TI Fatness is related to blunted vascular stress responsivity, independent
   of cardiorespiratory fitness in normal and overweight men
SO INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY
LA English
DT Article
DE psychosocial stress; vascular function; cardiovascular risk;
   cardiorespiratory fitness; obesity
ID SYMPATHETIC-NERVE ACTIVITY; CORONARY-HEART-DISEASE; BODY-MASS INDEX;
   PHYSICAL-ACTIVITY; CARDIOVASCULAR-DISEASE; FAT DISTRIBUTION; AEROBIC
   FITNESS; ARTERIAL STIFFNESS; METABOLIC SYNDROME; BLOOD-PRESSURE
AB Obesity is associated with disturbed cardiovascular responsivity to mental stress, which may mediate psychosocial disease pathways. Whether being aerobically fit is protective against psychophysiological dysfunction in the presence of overweight or obesity is undetermined. Peripheral blood flow, blood pressure, and cardiac responses were measured during a 2-min mental stress task in 48 healthy men (aged 18-32 years). Mental stress-evoked increases in mean arterial pressure and heart rate, forearm vasodilatation, and cardiac parasympathetic withdrawal. Multiple linear regression analyses adjusted for age, peak oxygen uptake, and baseline forearm vascular resistance, revealed that greater fatness was related to a blunted vasodilatation response to mental stress (beta = -.31, p <.05). There were no interactive effects of fitness and fatness. Fitness does not appear to moderate the association between fatness and impaired vascular stress responsivity in normal and overweight men. (c) 2006 Elsevier B.V. All rights reserved.
C1 UCL, Dept Epidemiol & Publ Hlth, Psychobiol Grp, London WC1E 6BT, England.
   Univ New S Wales, Fac Med, Sch Med Sci, Sydney, NSW, Australia.
C3 University of London; University College London; University of New South
   Wales Sydney
RP Hamer, M (corresponding author), UCL, Dept Epidemiol & Publ Hlth, Psychobiol Grp, 1-19 Torrington Pl, London WC1E 6BT, England.
EM m.hamer@ucl.ac.uk
RI Hamer, Mark/C-1602-2008
OI Hamer, Mark/0000-0002-8726-7992
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NR 46
TC 18
Z9 18
U1 0
U2 5
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0167-8760
EI 1872-7697
J9 INT J PSYCHOPHYSIOL
JI Int. J. Psychophysiol.
PD MAR
PY 2007
VL 63
IS 3
BP 251
EP 257
DI 10.1016/j.ijpsycho.2006.11.002
PG 7
WC Psychology, Biological; Neurosciences; Physiology; Psychology;
   Psychology, Experimental
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Neurosciences & Neurology; Physiology
GA 149SP
UT WOS:000245167200004
PM 17196278
DA 2025-06-11
ER

PT J
AU Heyman, A
   Lavalle, JB
   Hawkins, EB
   Edwards, L
AF Heyman, Andrew
   Lavalle, James B.
   Hawkins, Ernest B.
   Edwards, Lena
TI An integrative medicine approach to managing nutrient depletions in the
   cardiometabolic patient
SO JOURNAL OF MENS HEALTH
LA English
DT Article
DE Cardiometabolic disease; Nutritient depletion
ID TYPE-2 DIABETES-MELLITUS; VITAMIN-D DEFICIENCY; COENZYME Q(10); SERUM
   25-HYDROXYVITAMIN-D; CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; DIETARY
   MAGNESIUM; MYOCARDIAL-INFARCTION; INSULIN-RESISTANCE; CLINICAL MEDICINE
AB This article presents a further exploration of the risk factors underlying cardiometabolic (CM) disease and their identification and management within an integrative medicine framework as illustrated by the case of a 30-year-old obese African American male who presented for a follow-up visit with regard to his metabolic syndrome (MeS)
   This article reviews in detail the pathophysiology of common nutrient depletions and their contribution to CM disease risk as well as drug-induced nutrient depletions incurred curing treatment for CM disease and the MeS The review also includes a detailed discussion on the evaluation and treatment of nutrient deficiencies
   The article concludes with a detailed discussion of the case resolution Following an extensive metabolic evaluation a program of specific nutrient repletion was instituted alongside testosterone replacement therapy in addition to instituting stress reduction techniques and herbal supplements to improve his physiologic stress response The patient returned to clinic after 3 months to review progress and laboratory results He had lost 15 pounds reported increased energy levels and complete elimination of joint aches He was scheduled to return to the clinic after a further 3 months for re-evaluation (C) 2010 WPMH GmbH Published by Elsevier Ireland Ltd
C1 [Heyman, Andrew] Univ Michigan, Sch Med, Dept Family Med, Ann Arbor, MI 48109 USA.
   [Lavalle, James B.] Univ Cincinnati, Coll Pharm, Cincinnati, OH 45267 USA.
   [Hawkins, Ernest B.] Integrat Hlth Resources, Asheville, NC USA.
   [Edwards, Lena] Balance Hlth & Wellness Ctr, Lexington, KY USA.
C3 University of Michigan System; University of Michigan; University System
   of Ohio; University of Cincinnati
RP Heyman, A (corresponding author), Univ Michigan, Sch Med, Dept Family Med, Ann Arbor, MI 48109 USA.
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NR 81
TC 0
Z9 0
U1 0
U2 0
PU DOUGMAR PUBLISHING GROUP INC
PI HAMILTON
PA 1 HUNTER ST E STE G-100, HAMILTON, ONTARIO L8N-3W1, CANADA
SN 1875-6859
J9 J MENS HEALTH
JI J. Mens Health
PD JUN
PY 2010
VL 7
IS 2
BP 145
EP 158
DI 10.1016/j.jomh.2010.01.002
PG 14
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA 687WO
UT WOS:000284809100005
DA 2025-06-11
ER

PT J
AU Devaraj, S
   Wang-Polagruto, J
   Polagruto, J
   Keen, CL
   Jialal, I
AF Devaraj, Sridevi
   Wang-Polagruto, Janice
   Polagruto, John
   Keen, Carl L.
   Jialal, Ishwarlal
TI High-fat, energy-dense, fast-food-style breakfast results in an increase
   in oxidative stress in metabolic syndrome
SO METABOLISM-CLINICAL AND EXPERIMENTAL
LA English
DT Article
ID ENDOTHELIAL FUNCTION; DIET
AB The metabolic syndrome (MetS) is associated with an increased incidence of diabetes and coronary heart disease. Postprandial lipemia is a prominent feature of dyslipidemia in both type 2 diabetes mellitus and MetS and is also associated with coronary heart disease. Oxidative stress and inflammation are pivotal in all stages of atherosclerosis; however, there is a paucity of data on postprandial oxidative stress, and inflammation in subjects with MetS. Thus, the primary aim of this study was to compare the postprandial effects of an energy-dense, high-fat, fast-food-style (FFS) meal with an American Heart Association (AHA)-recommended heart-healthy meal on biomarkers of oxidative stress and inflammation in subjects with MetS. A total of 11 subjects with MetS completed the study. Glucose levels were significantly increased 2 hours after both FFS and AHA diets (P<.0001), and high-density lipoprotein cholesterol levels significantly decreased in FFS diet but not in the AHA diet (P for interaction<.05). Total triglyceride levels significantly increased postprandially only in the FFS meal but not in the AHA meal (P for interaction=.03). Plasma thiobarbituric acid reactive substances and malondialdehyde + hydroxynonenal increased significantly with time in both dietary groups, and the postprandial increase was greater in the FFS diet compared to the AHA diet (P<.0005). Serum high-sensitivity C-reactive protein, interleukin 6, and tumor necrosis factor levels did not change with time or dietary treatment. The postprandial increase in interleukin 1b was significantly higher with the FFS meal, thus resulting in significant differences between both treatments (P for interaction=.03). Thus, in subjects with MetS, consumption of an energy-dense, fatty meal (FFS breakfast) results in increased postprandial oxidative stress compared to a heart-healthy meal (AHA). (C) 2008 Elsevier Inc. All rights reserved.
C1 [Devaraj, Sridevi; Jialal, Ishwarlal] Univ Calif Davis, Med Ctr, Lab Atherosclerosis & Metab Res, Sacramento, CA 95817 USA.
   [Wang-Polagruto, Janice; Polagruto, John; Keen, Carl L.] Univ Calif Davis, Med Ctr, Dep Pathol & Nutr, Sacramento, CA 95817 USA.
   [Jialal, Ishwarlal] VANCHS, Mather, CA 95655 USA.
C3 University of California System; University of California Davis;
   University of California System; University of California Davis
RP Jialal, I (corresponding author), Univ Calif Davis, Med Ctr, Lab Atherosclerosis & Metab Res, Sacramento, CA 95817 USA.
EM ishwarlal.jialal@ucdm.ucdavis.edu
RI Jialal, Ishwarlal/AAG-6218-2019
FU NCCIH NIH HHS [K24 AT000596, K24 AT 00596] Funding Source: Medline
CR Burdge GC, 2005, BRIT J NUTR, V93, P3, DOI 10.1079/BJN20041282
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NR 18
TC 120
Z9 135
U1 0
U2 11
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0026-0495
EI 1532-8600
J9 METABOLISM
JI Metab.-Clin. Exp.
PD JUN
PY 2008
VL 57
IS 6
BP 867
EP 870
DI 10.1016/j.metabol.2008.02.016
PG 4
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 312BF
UT WOS:000256643400020
PM 18502272
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Cisternas, P
   Gherardelli, C
   Gutierrez, J
   Salazar, P
   Mendez-Orellana, C
   Wong, GW
   Inestrosa, NC
AF Cisternas, Pedro
   Gherardelli, Camila
   Gutierrez, Joel
   Salazar, Paulina
   Mendez-Orellana, Carolina
   Wong, G. William
   Inestrosa, Nibaldo C.
TI Adiponectin and resistin modulate the progression of Alzheimer's disease
   in a metabolic syndrome model
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Article
DE adiponectin; resistin; obesity; Alzheimer ' s disease; glucose
   metabolism
ID CEREBRAL GLUCOSE-UPTAKE; HIGH-FAT DIET; INSULIN-RESISTANCE; MOUSE MODEL;
   OXIDATIVE STRESS; COGNITIVE IMPAIRMENT; AMYLOID-BETA; NITRIC-OXIDE;
   IN-VIVO; A-BETA
AB Metabolic syndrome (MetS), a cluster of metabolic conditions that include obesity, hyperlipidemia, and insulin resistance, increases the risk of several aging-related brain diseases, including Alzheimer's disease (AD). However, the underlying mechanism explaining the link between MetS and brain function is poorly understood. Among the possible mediators are several adipose-derived secreted molecules called adipokines, including adiponectin (ApN) and resistin, which have been shown to regulate brain function by modulating several metabolic processes. To investigate the impact of adipokines on MetS, we employed a diet-induced model to induce the various complications associated with MetS. For this purpose, we administered a high-fat diet (HFD) to both WT and APP/PSN1 mice at a pre-symptomatic disease stage. Our data showed that MetS causes a fast decline in cognitive performance and stimulates A beta(42) production in the brain. Interestingly, ApN treatment restored glucose metabolism and improved cognitive functions by 50% while decreasing the A beta(42/40) ratio by approximately 65%. In contrast, resistin exacerbated Ab pathology, increased oxidative stress, and strongly reduced glucose metabolism. Together, our data demonstrate that ApN and resistin alterations could further contribute to AD pathology.
C1 [Cisternas, Pedro] Univ Ohiggins, Inst Ciencias Salud, Rancagua, Chile.
   [Gherardelli, Camila; Gutierrez, Joel; Salazar, Paulina; Inestrosa, Nibaldo C.] Pontificia Univ Catolica Chile, Fac Ciencias Biol, Ctr Envejecimiento & Regenerac CARE UC, Dept Biol Celular & Mol, Santiago, Chile.
   [Mendez-Orellana, Carolina] Pontificia Univ Catolica Chile, Fac Med, Dept Ciencias Salud, Carrera Fonoaudiol, Santiago, Chile.
   [Wong, G. William] Johns Hopkins Univ, Sch Med, Dept Physiol, Baltimore, MD USA.
   [Wong, G. William] Johns Hopkins Univ, Sch Med, Ctr Metab & Obes Res, Baltimore, MD USA.
   [Inestrosa, Nibaldo C.] Univ Magallanes, Ctr Excelencia Biomed Magallanes CEBIMA, Punta Arenas, Chile.
C3 Universidad de O'Higgins; Pontificia Universidad Catolica de Chile;
   Pontificia Universidad Catolica de Chile; Johns Hopkins University;
   Johns Hopkins University; Universidad de Magallanes
RP Cisternas, P (corresponding author), Univ Ohiggins, Inst Ciencias Salud, Rancagua, Chile.; Inestrosa, NC (corresponding author), Pontificia Univ Catolica Chile, Fac Ciencias Biol, Ctr Envejecimiento & Regenerac CARE UC, Dept Biol Celular & Mol, Santiago, Chile.; Inestrosa, NC (corresponding author), Univ Magallanes, Ctr Excelencia Biomed Magallanes CEBIMA, Punta Arenas, Chile.
EM pedro.cisternas@uoh.cl; ninestrosa@bio.puc.cl
FU Basal Center of Excellence in Aging and Regeneration [CONICYT-AFB
   170005]; FONDECYT [11160651]
FX This work was supported by grants from the Basal Center of Excellence in
   Aging and Regeneration (CONICYT-AFB 170005) to NI, FONDECYT (no.
   11160651) to PC. We also thank the Sociedad Quimica y Minera de Chile
   (SQM) for the special grants "The Role of K+ on Hypertension and
   Cognition", "The Role of Lithiumin Human Health and Disease", and "Fondo
   interdisciplina del departamento Ciencias de la salud, P. Universidad
   Catolica de Chile" to CM-O, and the Puente Fund of the Universidad de
   O'Higgins.
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NR 117
TC 10
Z9 10
U1 0
U2 4
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD SEP 4
PY 2023
VL 14
AR 1237796
DI 10.3389/fendo.2023.1237796
PG 16
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA S1CB4
UT WOS:001068605300001
PM 37732123
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU DeLeve, LD
   Wang, XD
   Kanel, GC
   Atkinson, RD
   McCuskey, RS
AF DeLeve, Laurie D.
   Wang, Xiangdong
   Kanel, Gary C.
   Atkinson, Roscoe D.
   McCuskey, Robert S.
TI Prevention of hepatic fibrosis in a murine model of metabolic syndrome
   with nonalcoholic steatohepatitis
SO AMERICAN JOURNAL OF PATHOLOGY
LA English
DT Article
ID EXTRACELLULAR-MATRIX; INSULIN-RESISTANCE; GENE-EXPRESSION; RECEPTOR;
   LEPTIN; PLASMA; ATHEROSCLEROSIS; LIPOPROTEIN; ACTIVATION; STEATOSIS
AB The endocannabinoid pathway plays an important role in the regulation of appetite and body weight, hepatic lipid metabolism, and fibrosis. Blockade of the endocannabinoid receptor CBI with SR141716 promotes weight loss, reduces hepatocyte fatty acid synthesis, and is antifibrotic. D-4F, an apolipoprotein A-1 mimetic with antioxidant properties, is currently in clinical trials for the treatment of atherosclerosis. C57BL/6J mice were fed a high-fat diet for 7 months, followed by a 2.5-month treatment with either SR141716 or D-417. SR141716 markedly improved body weight, liver weight, serum transaminases, insulin resistance, hyperglycemia, hypercholesterolemia, hyerleptinemia, and oxidative stress, accompanied by the significant prevention of fibrosis progression. D-4F improved hypercholesterolemia and hyperleptinemia without improvement in body weight, steatohepatitis, insulin resistance, or oxidative stress, and yet, there was significant prevention of fibrosis. D-4F prevented culture-induced activation of stellate cells in vitro. In summary, C57BL/6J mice given a high-fat diet developed features of metabolic syndrome with nonalcoholic steatohepatitis and fibrosis. Both SR141716 and D-417 prevented progression of fibrosis after onset of steatohepatitis, ie, a situation comparable to a common clinical scenario, with D-4F seeming to have a more general antifibrotic effect. Either compound therefore has the potential to be of clinical benefit.
C1 [DeLeve, Laurie D.; Wang, Xiangdong] Univ So Calif, Keck Sch Med, Div Gastrointestinal & Liver Dis, Los Angeles, CA 90033 USA.
   [DeLeve, Laurie D.; Wang, Xiangdong] Univ So Calif, Keck Sch Med, Res Ctr Liver Dis, Los Angeles, CA 90033 USA.
   [McCuskey, Robert S.] Univ Arizona, Dept Cell Biol & Anat, Tucson, AZ USA.
   [Kanel, Gary C.; Atkinson, Roscoe D.] Univ So Calif, Keck Sch Med, Dept Pathol, Los Angeles, CA 90033 USA.
C3 University of Southern California; University of Southern California;
   University of Arizona; University of Southern California
RP DeLeve, LD (corresponding author), Univ So Calif, Keck Sch Med, Div GI Liver Dis, 2011 Zonal Ave,HMR603, Los Angeles, CA 90033 USA.
EM deleve@usc.edu
RI DeLeve, Laurie/F-3549-2012
FU National Institutes of Health [DK66423]; Morphology Core of the
   University of Southern California Research Center for Liver Diseases;
   Nonparerchymal Liver Cell Core of the Southern California Research
   Center for Alcoholic Liver and Pancreatic Diseases and Cirrhosis
FX Supported by the National Institutes of Health (grant DK66423), the
   Morphology Core of the University of Southern California Research Center
   for Liver Diseases, and the Nonparerchymal Liver Cell Core of the
   Southern California Research Center for Alcoholic Liver and Pancreatic
   Diseases and Cirrhosis.
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NR 28
TC 85
Z9 96
U1 0
U2 7
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0002-9440
EI 1525-2191
J9 AM J PATHOL
JI Am. J. Pathol.
PD OCT
PY 2008
VL 173
IS 4
BP 993
EP 1001
DI 10.2353/ajpath.2008.070720
PG 9
WC Pathology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pathology
GA 354OD
UT WOS:000259648000009
PM 18772330
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Kahl, KG
   Utanir, F
   Schweiger, U
   Krüger, TH
   Frieling, H
   Bleich, S
   Gutberlet, M
   Hartung, D
AF Kahl, Kai G.
   Utanir, Ferdi
   Schweiger, Ulrich
   Krueger, Tillmann H.
   Frieling, Helge
   Bleich, Stefan
   Gutberlet, Marcel
   Hartung, Dagmar
TI Reduced muscle mass in middle-aged depressed patients is associated with
   male gender and chronicity
SO PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
LA English
DT Article
DE Depression; Physical health; Neuroendocrinology; Internal medicine;
   Magnetic resonance imaging
ID PERICARDIAL ADIPOSE-TISSUE; SKELETAL-MUSCLE; METABOLIC SYNDROME;
   SARCOPENIA ORIGINS; PHYSICAL-ACTIVITY; BIPOLAR DISORDER;
   NATIONAL-HEALTH; OLDER MEN; EXERCISE; TESTOSTERONE
AB Objective: Reduced muscle mass is a characteristic finding in sarcopenia, the central element of physical frailty syndrome, and a major cause of physical function decay, morbidity and mortality in the elderly. Studies so far demonstrated reduced muscle mass in depressed patients with an average age over 60 years. An open question is whether muscle mass reduction is already observed earlier. Therefore, muscle mass was assessed in middle-aged male and female depressive patients, and the findings were related to indicators of hypothalamus pituitary adrenal axis activation, lifestyle factors, endocrine and immune measures.
   Methods: Sixty-seven depressed patients (mean age 38.6y; 582% female) and 26 healthy volunteers (mean age 40.5y; 61.5% female) were included. Muscle mass, adrenal gland volume, and intra-abdominal adipose tissue were assessed by magnetic resonance tomography. Laboratory parameters included fasting cortisol, pro inflammatory cytokines, factors constituting the metabolic syndrome, and relative insulin resistance according to the homeostasis model assessment (HOMA-IR).
   Results: We found significant effects of depression (F = 42; P = 0.043) and gender (F = 182; P<0.001) on muscle mass. Muscle mass was reduced in depressed men compared to healthy men (F = 3.4; P = 0.044), particularly in those with chronic depression. In contrast, no such association was observed in depressed females. Adrenal gland volume and intra-abdominal fat was increased in depressed men and women, although not significantly. Correlations were observed for muscle mass with the amount of self-reported exercise and depression severity, and for depression severity with self-reported exercise. Further findings comprised lower self reported activity and higher cortisol concentrations in depressed male and female compared to healthy pro bands.
   Conclusions: Muscle mass is reduced in middle-aged depressed men, particularly those with chronic disease course. This association is not observed in depressed females, possibly pointing to the role of female sex steroids in maintaining muscle mass. The increase of adrenal gland volume in depressed patients may point to the role of a dysregulated hypothalamus-pituitary-adrenal system. The inverse association of exercise with muscle mass demonstrates the importance of physical activity. Looking at the long term consequences of reduced muscle mass, interventions to preserve and rebuild muscle mass in depression-such as structured exercise interventions -should be recommended.
   Significant outcomes: Muscle mass is decreased in male patients with major depressive disorder, particular those with chronic disease course. This difference was not observed in female depressed patients. The extent of muscle mass reduction is correlated to depression severity and inversely to physical activity, pointing to the role of depression associated inactivity. Low muscle mass is a risk factor for physical frailty, therefore interventions aiming at improving physical fitness may be recommended. Limitations: Sex steroids were not assessed in the study groups. (C) 2017 Elsevier Inc. All rights reserved.
C1 [Kahl, Kai G.; Utanir, Ferdi; Krueger, Tillmann H.; Frieling, Helge; Bleich, Stefan] Hannover Med Sch, Dept Psychiat Social Psychiat & Psychotherapy, Carl Neuberg Str 1, D-30625 Hannover, Germany.
   [Gutberlet, Marcel; Hartung, Dagmar] Hannover Med Sch, Dep Diagnost & Intervent Radiol, Hannover, Germany.
   [Schweiger, Ulrich] Univ Lubeck, Dep Psychiat & Psychotherapy, Lubeck, Germany.
C3 Hannover Medical School; Hannover Medical School; University of Lubeck
RP Kahl, KG (corresponding author), Hannover Med Sch, Dept Psychiat Social Psychiat & Psychotherapy, Carl Neuberg Str 1, D-30625 Hannover, Germany.
EM kahl.kai@mh-hannover.de
RI Bleich, Stefan/ABC-1796-2020; Kruger, Tillmann/F-3493-2012; Gutberlet,
   Matthias/AAL-2699-2021; Frieling, Helge/C-5299-2015
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NR 81
TC 10
Z9 10
U1 0
U2 15
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0278-5846
EI 1878-4216
J9 PROG NEURO-PSYCHOPH
JI Prog. Neuro-Psychopharmacol. Biol. Psychiatry
PD JUN 2
PY 2017
VL 76
BP 58
EP 64
DI 10.1016/j.pnpbp.2017.01.009
PG 7
WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA EY9LR
UT WOS:000404320600007
PM 28132777
DA 2025-06-11
ER

PT J
AU Schrier, AC
   Ujcic-Voortman, JK
   de Wit, MAS
   Verhoeff, AP
   Kupka, R
   Dekker, J
   Beekman, ATF
AF Schrier, Agnes C.
   Ujcic-Voortman, Joanne K.
   de Wit, Matty A. S.
   Verhoeff, Arnoud P.
   Kupka, Ralph
   Dekker, Jack
   Beekman, Aartjan T. F.
TI Ethnic differences in the association between cardiovascular risk
   factors and psychological distress in a population study in the
   Netherlands
SO BMC PUBLIC HEALTH
LA English
DT Article
DE Obesity; Cardiovascular; Depression; Ethnicity; Epidemiology
ID MAJOR DEPRESSIVE DISORDER; METABOLIC SYNDROME; SCREENING SCALES; NATIVE
   DUTCH; FOLLOW-UP; OBESITY; ANXIETY; SYMPTOMS; TURKISH; HEALTH
AB Background: There is growing body of evidence of an association between cardiovascular risk factors and depressive and anxiety symptoms. The purpose of this study was to investigate whether these associations are similar in ethnic minority groups.
   Methods: A random urban population sample, aged 18+, stratified by ethnicity (484 native Dutch subjects, 383 Turkish-Dutch subjects, and 316 Moroccan-Dutch subjects), in Amsterdam, the Netherlands, was interviewed with the Kessler Psychological Distress scale (K10) in combination with measurements of several cardiovascular risk factors. The association of psychological distress (defined as a K10 score above cut-off of 20) with cardiovascular risk factors (obesity, abdominal obesity, hypertension, hypercholesterolemia, low HDL cholesterol levels or diabetes), ethnicity and their interaction was analyzed using logistic regression analyses, stratified by gender and adjusted for age.
   Results: Cardiovascular risk factors were not significantly associated with psychological distress in any of the gender/ethnic groups, with the exception of a positive association of obesity and hypertension with psychological distress in native Dutch women and a negative association of hypertension and psychological distress in Turkish men. Interaction terms of cardiovascular risk factors and ethnicity were approaching significance only in the association of obesity with the K10 in women.
   Conclusion: In this cross-sectional multi-ethnic adult population sample the majority of the investigated cardiovascular risk factors were not associated with psychological distress. The association of obesity with psychological distress varies by gender and ethnicity. Our findings indicate that the prevention of obesity and psychological distress calls for an integrated approach in native Dutch women, but not necessarily in Turkish-Dutch and Moroccan-Dutch women, in whom these problems may be targeted separately.
C1 [Schrier, Agnes C.; Kupka, Ralph] Altrecht Inst Mental Hlth Care, Utrecht, Netherlands.
   [Ujcic-Voortman, Joanne K.; de Wit, Matty A. S.; Verhoeff, Arnoud P.] Publ Hlth Serv Amsterdam, Dept Epidemiol, Amsterdam, Netherlands.
   [Verhoeff, Arnoud P.] Univ Amsterdam, Dept Sociol & Anthropol, Amsterdam, Netherlands.
   [Kupka, Ralph; Beekman, Aartjan T. F.] Vrije Univ Amsterdam, Med Ctr, Dept Psychiat, Amsterdam, Netherlands.
   [Dekker, Jack] Vrije Univ Amsterdam, Med Ctr, Dept Clin Psychol, Amsterdam, Netherlands.
   [Dekker, Jack; Beekman, Aartjan T. F.] Vrije Univ Amsterdam, Med Ctr, EMGO Inst Hlth & Care Res, Amsterdam, Netherlands.
C3 Public Health Service Amsterdam; University of Amsterdam; Vrije
   Universiteit Amsterdam; Vrije Universiteit Amsterdam; Vrije Universiteit
   Amsterdam
RP Schrier, AC (corresponding author), Altrecht Inst Mental Hlth Care, Utrecht, Netherlands.
EM a.schrier@altrecht.nl
RI Beekman, Aartjan T./LUZ-6919-2024; Verhoeff, Arnoud/F-7924-2013; Kupka,
   Ralph/HDM-4184-2022
OI Kupka, Ralph/0000-0002-1662-7436
FU Municipality of Amsterdam; National Institute of Public Health;
   Environment in the Netherlands; Public Health Service Amsterdam;
   Altrecht Institute for Mental Health
FX The data collection of the study was financed by the Municipality of
   Amsterdam and the National Institute of Public Health and the
   Environment in the Netherlands. The data analyses built on the work of
   Mrs. Joanne Ujcic-Voortman, who is financed by the Public Health Service
   Amsterdam. Mrs. A. C. Schrier was supported by Altrecht Institute for
   Mental Health during data analysis and writing of the manuscript.
CR Agyemang C, 2006, J HYPERTENS, V24, P2169, DOI 10.1097/01.hjh.0000249693.73618.c9
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   World Health Organization, 2000, 903 WHO
NR 41
TC 2
Z9 3
U1 1
U2 12
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2458
J9 BMC PUBLIC HEALTH
JI BMC Public Health
PD DEC 18
PY 2012
VL 12
AR 1090
DI 10.1186/1471-2458-12-1090
PG 7
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA 077OB
UT WOS:000314035900001
PM 23249268
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Burgueño, AL
   Juarez, YR
   Genaro, AM
   Tellechea, ML
AF Burgueno, Adriana L.
   Juarez, Yamila R.
   Genaro, Ana M.
   Tellechea, Mariana L.
TI Systematic review and meta-analysis on the relationship between prenatal
   stress and metabolic syndrome intermediate phenotypes
SO INTERNATIONAL JOURNAL OF OBESITY
LA English
DT Review
ID BODY-MASS INDEX; PARENTAL PSYCHOLOGICAL DISTRESS; MATERNAL STRESS;
   WEIGHT-GAIN; DEHYDROGENASE TYPE-2; PSYCHOSOCIAL STRESS; PERINATAL
   OUTCOMES; BLOOD-PRESSURE; TRAFFIC NOISE; EARLY GROWTH
AB Background Metabolic Syndrome (MetS) can be considered as a consequence of a complex interplay between genetic and environmental factors and can be influenced by changes in the environment early in life. Prenatal stress (PS) exposure likely represents an important adverse intrauterine environment that may impact the biology of the developing organism. The aim of this study was to quantitatively synthesize the available data on the effects of PS on offspring's obesity, estimated indirectly by body mass index (BMI) and body fat; blood pressure, plasma glucose and blood lipid concentrations (triglycerides and high-density lipoprotein cholesterol). Methods Literature searches for eligible studies on PubMed were conducted until October 8, 2018. Full text review yielded 24 publications for inclusion into the systematic review. Meta-analyses were performed for the outcomes BMI and body fat. 62 effect sizes from 19 studies together with relevant moderators were collected. Summary estimates were calculated by using random-effects model. Results The combined standardized mean difference (d) for the relation between BMI and PS indicated that despite significant heterogeneity, stress exposure of expectant mothers was associated with increased BMI of their offspring [d (95% CI) = 0.268 (0.191; 0.345)]. Both objective and subjective stress have been linked to increased overweight. Preliminary results of the relationship between PS and body fat suggested that the contribution of PS to body fat should be at least further considered [d (95% CI) = 0.167 (0.016; 0.317)]. Evidence from a limited number of published studies do not sustains an effect on blood pressure, glucose metabolism or circulating lipids, however these outcomes have only been scarcely investigated. Conclusions A direct association between PS and BMI was found and further studies are needed to confirm the relationship between maternal stress during gestation and body fat. Overall, findings suggest that PS could contribute to alterations to the post-natal offspring phenotype.
C1 [Burgueno, Adriana L.; Juarez, Yamila R.; Genaro, Ana M.] Pontificia Univ Catolica Argentina, Consejo Nacl Invest Cient & Tecn CONICET, Inst Invest Biomed, Alicia Moreau de Justo 1600,C1107AFF, Buenos Aires, DF, Argentina.
   [Tellechea, Mariana L.] Hosp Ninos Dr Ricardo Gutierrez, Consejo Nacl Invest Cient & Tecn, Ctr Invest Endocrinol Dr Cesar Bergada, Fdn Endocrinol Infantil,Div Endocrinol, Gallo 1330,C1425EFD, Buenos Aires, DF, Argentina.
C3 Pontificia Universidad Catolica Argentina; Consejo Nacional de
   Investigaciones Cientificas y Tecnicas (CONICET); University of Buenos
   Aires; University of Buenos Aires Hospital; Consejo Nacional de
   Investigaciones Cientificas y Tecnicas (CONICET); Hospital de Ninos
   Doctor Ricardo Gutierrez
RP Tellechea, ML (corresponding author), Hosp Ninos Dr Ricardo Gutierrez, Consejo Nacl Invest Cient & Tecn, Ctr Invest Endocrinol Dr Cesar Bergada, Fdn Endocrinol Infantil,Div Endocrinol, Gallo 1330,C1425EFD, Buenos Aires, DF, Argentina.
EM mtellechea@cedie.org.ar
RI TELLECHEA, MARIANA/AAM-6673-2021
OI Genaro, Ana/0000-0003-0027-3503; TELLECHEA, MARIANA
   LORENA/0000-0002-1194-8433; Burgueno, Adriana L./0000-0001-7584-7044
FU Agencia Nacional de Promocion Cientifica Tecnologica [PICT-2015-1567,
   PICT 2016-2727]; PIP 2015-2017 (Consejo Nacional de Investigaciones
   Cientificas y Tecnicas) [11220150100163]
FX This study was partially supported by grants PICT-2015-1567, PICT
   2016-2727 (Agencia Nacional de Promocion Cientifica Tecnologica) and PIP
   2015-2017 No. 11220150100163 (Consejo Nacional de Investigaciones
   Cientificas y Tecnicas). ALB, AMG, and MLT are members of Consejo
   Nacional de Investigaciones Cientificas y Tecnicas.
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NR 68
TC 17
Z9 17
U1 0
U2 8
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0307-0565
EI 1476-5497
J9 INT J OBESITY
JI Int. J. Obes.
PD JAN
PY 2020
VL 44
IS 1
BP 1
EP 12
DI 10.1038/s41366-019-0423-z
PG 12
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA KH0JR
UT WOS:000510334700001
PM 31332277
DA 2025-06-11
ER

PT J
AU Rani, R
   Nain, S
   Paliwal, S
AF Rani, Rashmi
   Nain, Sumitra
   Paliwal, Sarvesh
TI A Review on Pharmacological Potential of Medicago sativa Linn.
SO CURRENT TRADITIONAL MEDICINE
LA English
DT Review
DE Medicago sativa; alfalfa; extract; medicinal plant; chemical
   constituents; pharmacological uses; diseases
ID ANTIOXIDANT ACTIVITY; AQUEOUS EXTRACT; IN-VITRO; ALFALFA; L.;
   CYTOTOXICITY; SEEDS
AB Background: Medicago sativa Linn. in Hindi, is called lasunghas, and in English, it is called alfalfa. It is a well-known crop of the Fabaceae family. Anyone can eat its sprouts as a salad vegetable. This plant has a wide range of uses as a feed crop and is tolerant to climate change. Objective: In this review, the authors discussed the active chemical constituents and pharmacological uses of Medicago sativa Linn. in various diseases. Methods: To compile this review, information is collected the research papers from different databases like Taylor & Francis, ResearchGate, Elsevier, PubMed, Wiley Online Library, and PMC. Results Alfalfa has been shown to be an important origin of phytochemicals like amino acids, coumarins, alkaloids, carotenes, flavonoids, organic acids, digestive enzymes, phytosterols, saponins, phytoestrogens, phenolic compounds, polyamines, and a few other volatile organic compounds like ketones, terpenes, alcohols and furanoids. This plant is useful in CNS disorders, anxiety, oxidative stress, hepatotoxicity, inflammation, cancer, atherosclerosis, diabetes, burn wounds, vitiligo, reproductive system, myocardial infraction, bacteria, xanthine oxidase and metabolic syndrome. Conclusion: This review may be helpful in knowing of Medicago sativa Linn. with greater therapeutic potential for treatment of various diseases.
C1 [Rani, Rashmi; Nain, Sumitra; Paliwal, Sarvesh] Banasthali Vidyapith, Dept Pharm, Newai, Rajasthan, India.
C3 Banasthali Vidyapith
RP Nain, S (corresponding author), Banasthali Vidyapith, Dept Pharm, Newai, Rajasthan, India.
EM nainsumitra@gmail.com
RI Nain, Sumitra/R-8987-2019
OI Nain, Dr. Sumitra/0000-0001-8238-3145
FX The authors are thankful to the Honorable Vice-Chancellor of Banasthali
   Vidyapith Rajasthan for providing the essential facilities.
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NR 46
TC 1
Z9 1
U1 4
U2 5
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 2215-0838
EI 2215-0846
J9 CURR TRADIT MED
JI Curr. Tradit. Med.
PY 2024
VL 10
IS 7
AR e070923220781
DI 10.2174/2215083810666230907093431
PG 7
WC Integrative & Complementary Medicine
WE Emerging Sources Citation Index (ESCI)
SC Integrative & Complementary Medicine
GA E9S5Q
UT WOS:001306328500006
DA 2025-06-11
ER

PT J
AU Yu, BN
   Cook, C
   Santanam, N
AF Yu, Bangning
   Cook, Carla
   Santanam, Nalini
TI The Aporphine Alkaloid Boldine Induces Adiponectin Expression and
   Regulation in 3T3-L1 Cells
SO JOURNAL OF MEDICINAL FOOD
LA English
DT Article
DE adipogenesis; antioxidant; oxidative stress; peroxisome
   proliferator-activated receptors
ID OXIDATIVE STRESS; OXIDATIVE/NITRATIVE STRESS; ADIPOCYTE DIFFERENTIATION;
   INSULIN SENSITIVITY; GENE-TRANSCRIPTION; LIPID-PEROXIDATION; METABOLIC
   SYNDROME; SIGNALING PATHWAY; ADIPOSE-TISSUE; DIABETIC-RATS
AB Adiponectin is an adipokine secreted by differentiated adipocytes. Clinical studies suggest a negative correlation between oxidative stress and adiponectin levels in patients with metabolic syndrome or cardiovascular disease. Natural compounds that can prevent oxidative stress mediated inhibition of adiponectin may be potentially therapeutic. Boldine, an aporphine alkaloid abundant in the medicinal plant Peumus boldus, is a powerful antioxidant. The current study demonstrates the effects of boldine on the expression of adiponectin and its regulators, CCAAT/enhancer binding protein-alpha (C/EBP Chi) and peroxisome proliferator-activated receptor (PPAR)-gamma, in 3T3-L1 cells. Differentiated 3T3-L1 adipocytes were exposed to either hydrogen peroxide (H2O2) (100 mu M) or tumor necrosis factor-alpha (TNF alpha) (1 ng/mL) for 24 hours in the presence or absence of increasing concentrations of boldine (5-100 mu M). Quantitative polymerase chain reaction showed that both the oxidants decreased the mRNA levels of adiponectin, PPAR gamma, and C/EBP alpha to half of the control levels. Boldine, at all concentrations, counteracted the inhibitory effect of H2O2 or TNFa and increased the expression of adiponectin and its regulators. The effect of boldine on adiponectin expression was biphasic, with the lower concentrations (5-25 mu M) having a larger inductive effect compared to higher concentrations (50-100 mu M). Boldine treatment alone in the absence of H2O2 or TNF alpha was also able to induce adiponectin at the inductive phase of adipogenesis. Peroxisome proliferator response element-luciferase promoter transactivity analysis showed that boldine interacts with the PPAR response element and could potentially modulate PPAR responsive genes. Our results indicate that boldine is able to modulate the expression of adiponectin and its regulators in 3T3-L1 cells and has the potential to be beneficial in obesity-related cardiovascular disease.
C1 [Cook, Carla; Santanam, Nalini] Marshall Univ, Dept Pharmacol Physiol & Toxicol, Joan C Edwards Sch Med, Huntington, WV 25755 USA.
   [Yu, Bangning] Louisiana State Univ, Hlth Sci Ctr, Dept Pharmacol, New Orleans, LA USA.
C3 Marshall University; Louisiana State University System; Louisiana State
   University Health Sciences Center New Orleans
RP Santanam, N (corresponding author), Marshall Univ, Dept Pharmacol Physiol & Toxicol, Joan C Edwards Sch Med, 1 John Marshall Dr, Huntington, WV 25755 USA.
EM santanam@marshall.edu
OI Santanam, Nalini/0000-0003-3343-6081
FU National Institutes of Health [HL074239, 5P20RR016477]
FX The authors acknowledge support from grants HL074239 (to N.S.) and
   5P20RR016477 from the National Institutes of Health. The authors thank
   Dr. Gary Rankin, Ms. Amy Deborde, and Dr. Elsa Mangiarua for their help
   with proofreading our manuscript.
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NR 67
TC 16
Z9 18
U1 0
U2 17
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1096-620X
EI 1557-7600
J9 J MED FOOD
JI J. Med. Food
PD OCT
PY 2009
VL 12
IS 5
BP 1074
EP 1083
DI 10.1089/jmf.2008.0230
PG 10
WC Chemistry, Medicinal; Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Food Science & Technology; Nutrition &
   Dietetics
GA 511EE
UT WOS:000271145900020
PM 19857072
OA Green Published
DA 2025-06-11
ER

PT J
AU Kim, YK
   Song, J
AF Kim, Young-Kook
   Song, Juhyun
TI Metabolic imbalance and brain tumors: The interlinking metabolic
   pathways and therapeutic actions of antidiabetic drugs
SO PHARMACOLOGICAL RESEARCH
LA English
DT Article
DE Brain tumor; Metabolic syndrome; Antidiabetic drugs; Diabetes; Obesity
ID TYPE-2 DIABETES-MELLITUS; OXIDATIVE STRESS; ADIPOSE-TISSUE; CANCER-RISK;
   GLIOBLASTOMA; RECEPTOR; TEMOZOLOMIDE; METFORMIN; OBESITY; LEPTIN
AB Brain tumors are complex, heterogeneous malignancies, often associated with significant morbidity and mortality. Emerging evidence suggests the important role of metabolic syndrome, such as that observed in diabetes mellitus, in the progression of brain tumors. Several studies indicated that hyperglycemia, insulin resistance, oxidative stress, and altered adipokine profiles influence tumor growth, proliferation, and treatment resistance. Intriguingly, antidiabetic drugs (e.g., metformin, sulfonylureas, dipeptidyl peptidase-4 (DPP-4) inhibitors, glucagon-like peptide-1 (GLP-1) receptor agonists, and thiazolidinediones) have shown promise as adjunctive or repurposed agents in managing brain tumors. Metformin can impair tumor cell proliferation, enhance treatment sensitivity, and modify the tumor microenvironment by activating AMP-activated protein kinase (AMPK) and inhibiting mammalian target of rapamycin (mTOR) signaling pathways. DPP-4 inhibitors and GLP-1 receptor agonists can target both metabolic and inflammatory aspects of brain tumors, while thiazolidinediones may induce apoptosis in tumor cells and synergize with other therapeutics. Consequently, further studies and clinical trials are needed to confirm the efficacy, safety, and utility of metabolic interventions in treating brain tumors. Here, we review the evidence for the metabolic interconnections between metabolic diseases and brain tumors and multiple actions of anti-diabetes drugs in brain tumors.
C1 [Kim, Young-Kook] Chonnam Natl Univ, Med Sch, Dept Biochem, Hwasun 58128, Jeollanam Do, South Korea.
   [Song, Juhyun] Chonnam Natl Univ, Dept Anat, Med Sch, Hwasun 58128, Jeollanam Do, South Korea.
C3 Chonnam National University; Chonnam National University
RP Kim, YK (corresponding author), Chonnam Natl Univ, Med Sch, Dept Biochem, Hwasun 58128, Jeollanam Do, South Korea.; Song, J (corresponding author), Chonnam Natl Univ, Dept Anat, Med Sch, Hwasun 58128, Jeollanam Do, South Korea.
EM ykk@jnu.ac.kr; juhyunsong@chonnam.ac.kr
RI Song, Juhyun/AAH-3162-2020
FU National Research Foundation of Korea (NRF) , Republic of Korea
   [RS-2022-NR069292, RS-2024-00333553, RS-2024-00398786]
FX This study was supported by grants RS-2022-NR069292 (Juhyun Song) ,
   RS-2024-00333553 (Young-Kook Kim) , and RS-2024-00398786 (Young-Kook
   Kim) from the National Research Foundation of Korea (NRF) , Republic of
   Korea.
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NR 113
TC 0
Z9 0
U1 4
U2 4
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 1043-6618
EI 1096-1186
J9 PHARMACOL RES
JI Pharmacol. Res.
PD MAY
PY 2025
VL 215
AR 107719
DI 10.1016/j.phrs.2025.107719
EA APR 2025
PG 9
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 1BC5Y
UT WOS:001460811100001
PM 40174814
DA 2025-06-11
ER

PT J
AU Wu, Y
   Zhou, H
   Wu, K
   Lee, S
   Li, RJ
   Liu, X
AF Wu, Yong
   Zhou, Hillary
   Wu, Ke
   Lee, Sangkyu
   Li, Ruijin
   Liu, Xuan
TI PTEN Phosphorylation and Nuclear Export Mediate Free Fatty Acid-Induced
   Oxidative Stress
SO ANTIOXIDANTS & REDOX SIGNALING
LA English
DT Article
ID ACTIVATED PROTEIN-KINASE; NITRIC-OXIDE SYNTHASE; GLUTATHIONE-PEROXIDASE
   DEFICIENCY; TUMOR-SUPPRESSOR; P53 ACETYLATION; REACTIVE OXYGEN;
   ATHEROSCLEROSIS SUSCEPTIBILITY; ENDOTHELIAL DYSFUNCTION;
   SUPEROXIDE-DISMUTASE; METABOLIC SYNDROME
AB Aim: Oxidative stress induced by free fatty acids (FFA) contributes to metabolic syndrome-associated development of cardiovascular diseases, yet molecular mechanisms remain poorly understood. This study aimed at establishing whether phosphatase and tensin homolog deleted on chromosome 10 (PTEN) and its subcellular location play a role in FFA-induced endothelial oxidative stress. Results: Exposing human endothelial cells (ECs) with FFA activated mammalian target of rapamycin (mTOR)/S6K pathway, and upon activation, S6K directly phosphorylated PTEN at S380. Phosphorylation of PTEN increased its interaction with its deubiquitinase USP7 in the nucleus, leading to PTEN deubiquitination and nuclear export. The reduction of PTEN in the nucleus, in turn, decreased p53 acetylation and transcription, reduced the expression of the p53 target gene glutathione peroxidase-1 (GPX1), resulting in reactive oxygen species (ROS) accumulation and endothelial damage. Finally, C57BL/6J mice fed with high-fat atherogenic diet (HFAD) showed PTEN nuclear export, decreased p53 and GPX1 protein expressions, elevated levels of ROS, and significant lesions in aortas. Importantly, inhibition of mTOR or S6K effectively blocked these effects, suggesting that mTOR/S6K pathway mediates HFAD-induced oxidative stress and vascular damage via PTEN/p53/GPX1 inhibition in vivo. Innovation: Our study demonstrated for the first time that S6K directly phosphorylated PTEN at S380 under high FFA conditions, and this phosphorylation mediated FFA-induced endothelial oxidative stress. Furthermore, we showed that S380 phosphorylation affected PTEN monoubiquitination and nuclear localization, providing the first example of coordinated regulation of PTEN nuclear localization via phosphorylation and ubiquitination. Conclusion: Our studies provide a novel mechanism by which hyperlipidemia causes vascular oxidative damage through the phosphorylation of PTEN, blocking of PTEN nuclear function, and inhibition of p53/GPX1 activity. Antioxid. Redox Signal. 20, 1382-1395.
C1 [Wu, Yong; Zhou, Hillary; Lee, Sangkyu; Li, Ruijin; Liu, Xuan] Univ Calif Riverside, Dept Biochem, Riverside, CA 92521 USA.
   [Wu, Ke] Wuhan Univ, Med Res Ctr, ABSL Lab 3, Ctr Expt Anim, Hubei, Peoples R China.
C3 University of California System; University of California Riverside;
   Wuhan University
RP Liu, X (corresponding author), Univ Calif Riverside, Dept Biochem, Riverside, CA 92521 USA.
EM xuan.liu@ucr.edu
RI wu, ke/AHE-3113-2022
OI Wu, Yong/0000-0002-1698-0897; wu, ke/0000-0002-7195-9601
FU NIH [CA075180]; American Heart Association [POST3530033]
FX We are grateful to Dr. John Shyy for valuable suggestions and helpful
   discussion. We thank all members of our laboratory for discussions. This
   work was supported by NIH Grant CA075180 to X.L. and by American Heart
   Association Award POST3530033 to Y.W.
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NR 59
TC 38
Z9 42
U1 0
U2 23
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1523-0864
EI 1557-7716
J9 ANTIOXID REDOX SIGN
JI Antioxid. Redox Signal.
PD MAR 20
PY 2014
VL 20
IS 9
BP 1382
EP 1395
DI 10.1089/ars.2013.5498
PG 14
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA AB8BE
UT WOS:000332014300002
PM 24063548
OA Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Patel, PJ
   Weidenfeller, C
   Jones, AP
   Nilsson, J
   Hsu, J
AF Patel, Preeya J.
   Weidenfeller, Christian
   Jones, Andrew P.
   Nilsson, Jens
   Hsu, Jay
TI Long-Term Assessment of Lurasidone in Schizophrenia: Post Hoc Analysis
   of a 12-Month, Double Blind, Active-Controlled Trial and 6-Month
   Open-Label Extension Study
SO NEUROLOGY AND THERAPY
LA English
DT Article
DE Atypical antipsychotic; Cardiometabolic; Lurasidone; Metabolic syndrome;
   Prolactin; Risperidone; Schizophrenia; Switch
ID SCHIZOAFFECTIVE DISORDER; CONFIDENCE-INTERVALS; METABOLIC SYNDROME;
   SCALE; ANTIPSYCHOTICS; METAANALYSIS; PREVALENCE; MORTALITY; DISEASE;
   RISK
AB Introduction A post hoc analysis of a double-blind (DB) active control trial and an open-label extension (OLE) study was conducted to evaluate the long-term effects of lurasidone in patients with schizophrenia. Methods In the DB trial, patients were randomised to receive lurasidone or risperidone for 12 months. In OLE, all patients received lurasidone for an additional 6 months. Treatment-emergent adverse events (TEAEs) were evaluated. Efficacy assessments included relapse rate (DB trial only), and Positive and Negative Syndrome Scale, Clinical Global Impression-Severity scale, and Montgomery-angstrom sberg Depression Rating Scale. Results In the DB trial, patients with schizophrenia were randomised to lurasidone (n = 399) and risperidone (n = 190), of whom 129 and 84 continued into OLE, respectively. During the DB trial, incidence of TEAEs was similar for lurasidone (84.1%) and risperidone (84.2%). Lurasidone was associated with minimal changes in metabolic variables and prolactin levels, whereas risperidone was associated with clinically significant increases in prolactin and fasting glucose levels. The proportion of patients with metabolic syndrome was significantly lower in patients treated with lurasidone versus risperidone at the end of the DB trial (25.5% vs 40.4%; p = 0.0177). During OLE, patients switching from risperidone to lurasidone experienced a reduction in weight and prolactin levels; those continuing treatment with lurasidone experienced minimal changes in metabolic variables and prolactin. At the end of OLE, the proportion of patients with metabolic syndrome was no longer significantly different between groups (23.5% vs 31.5%; p = not significant). Efficacy outcomes were generally similar between groups during the DB trial, and were maintained during OLE. Conclusion Lurasidone was generally well tolerated and effective in clinically stable schizophrenia patients over the long term. Lurasidone was also generally well tolerated and maintained effectiveness over 6 months in patients switching from risperidone. Patients switching from risperidone experienced improvements in metabolic parameters and prolactin levels. These findings confirm lurasidone's long-term effectiveness and favourable metabolic profile in patients with schizophrenia.
C1 [Patel, Preeya J.; Weidenfeller, Christian; Jones, Andrew P.; Nilsson, Jens] Sunov Pharmaceut Europe Ltd, London, England.
   [Hsu, Jay] Sunov Pharmaceut Inc, Ft Lee, NJ USA.
C3 Dainippon Sumitomo Pharmaceutical Company; Sunovion Pharmaceuticals
   Inc.; Dainippon Sumitomo Pharmaceutical Company; Sunovion
   Pharmaceuticals Inc.
RP Patel, PJ (corresponding author), Sunov Pharmaceut Europe Ltd, London, England.
EM Preeya.Patel@sunovion.com
RI Rajagopalan, Krithika/AAZ-7034-2021; Jones, Andy/ABB-9742-2021
FU Sunovion Pharmaceuticals Europe Ltd.
FX The study was funded by Sunovion Pharmaceuticals Europe Ltd. The
   journal's Rapid Service Fees were also funded by Sunovion
   Pharmaceuticals Europe Ltd.
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NR 37
TC 5
Z9 6
U1 1
U2 4
PU SPRINGER LONDON LTD
PI LONDON
PA 236 GRAYS INN RD, 6TH FLOOR, LONDON WC1X 8HL, ENGLAND
SN 2193-8253
EI 2193-6536
J9 NEUROL THER
JI Neurol. Ther.
PD JUN
PY 2021
VL 10
IS 1
BP 121
EP 147
DI 10.1007/s40120-020-00221-4
EA OCT 2020
PG 27
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA SF9AL
UT WOS:000582312300001
PM 33098548
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Vona, R
   Gambardella, L
   Cittadini, C
   Straface, E
   Pietraforte, D
AF Vona, Rosa
   Gambardella, Lucrezia
   Cittadini, Camilla
   Straface, Elisabetta
   Pietraforte, Donatella
TI Biomarkers of Oxidative Stress in Metabolic Syndrome and Associated
   Diseases
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Review
ID INSULIN-RESISTANCE; NADPH OXIDASE; FRUCTOSE; OBESITY
AB Metabolic syndrome (MS) represents worldwide public health issue characterized by a set of cardiovascular risk factors including obesity, diabetes, dyslipidemia, hypertension, and impaired glucose tolerance. The link between the MS and the associated diseases is represented by oxidative stress (OS) and by the intracellular redox imbalance, both caused by the persistence of chronic inflammatory conditions that characterize MS. The increase in oxidizing species formation in MS has been accepted as a major underlying mechanism for mitochondrial dysfunction, accumulation of protein and lipid oxidation products, and impairment of the antioxidant systems. These oxidative modifications are recognized as relevant OS biomarkers potentially able to (i) clarify the role of reactive oxygen and nitrogen species in the etiology of the MS, (ii) contribute to the diagnosis/evaluation of the disease's severity, and (iii) evaluate the utility of possible therapeutic strategies based on natural antioxidants. The antioxidant therapies indeed could be able to (i) counteract systemic as well as mitochondrial-derived OS, (ii) enhance the endogenous antioxidant defenses, (iii) alleviate MS symptoms, and (iv) prevent the complications linked to MS-derived cardiovascular diseases. The focus of this review is to summarize the current knowledge about the role of OS in the development of metabolic alterations characterizing MS, with particular regard to the occurrence of OS-correlated biomarkers, as well as to the use of therapeutic strategies based on natural antioxidants.
C1 [Vona, Rosa; Gambardella, Lucrezia; Cittadini, Camilla; Straface, Elisabetta] Ist Super Sanita, Ctr Gender Specif Med, Biomarkers Unit, Rome, Italy.
   [Pietraforte, Donatella] Ist Super Sanita, Core Facil, Rome, Italy.
C3 Istituto Superiore di Sanita (ISS); Istituto Superiore di Sanita (ISS)
RP Straface, E (corresponding author), Ist Super Sanita, Ctr Gender Specif Med, Biomarkers Unit, Rome, Italy.
EM rosa.vona@iss.it; lucrezia.gambardella@iss.it;
   camilla.cittadini@virgilio.it; elisabetta.straface@iss.it;
   donatella.pietraforte@iss.it
RI Pietraforte, Donatella/G-1816-2011; Vona, Rosa/AAL-4747-2021; Cittadini,
   Camilla/HSC-1541-2023
OI Gambardella, Lucrezia/0000-0003-3899-5958; Cittadini,
   Camilla/0000-0002-1403-6608; Vona, Rosa/0000-0003-4501-8661
FU Ministry of Health [RF-2013-02358715]
FX This study was supported in part by a grant from the Ministry of Health
   (RF-2013-02358715) awarded to E.S. The authors thank Ms. Carlotta
   Catalano for the linguistic revision of the manuscript.
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NR 175
TC 232
Z9 246
U1 1
U2 28
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PY 2019
VL 2019
AR 8267234
DI 10.1155/2019/8267234
PG 19
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA HZ0YC
UT WOS:000468571200001
PM 31191805
OA Green Published, hybrid, Green Submitted
DA 2025-06-11
ER

PT J
AU Hong, Q
   Wang, LY
   Huang, ZY
   Feng, Z
   Cui, SY
   Fu, B
   Cai, GY
   Chen, XM
   Wu, D
AF Hong, Quan
   Wang, Liyuan
   Huang, Zhiyong
   Feng, Zhe
   Cui, Shaoyuan
   Fu, Bo
   Cai, Guangyan
   Chen, Xiangmei
   Wu, Di
TI High Concentrations of Uric Acid and Angiotensin II Act Additively to
   Produce Endothelial Injury
SO MEDIATORS OF INFLAMMATION
LA English
DT Article
ID OXIDATIVE STRESS; SUPEROXIDE-PRODUCTION; METABOLIC SYNDROME; CELL
   DYSFUNCTION; NITRIC-OXIDE; HYPERURICEMIA; HYPERTENSION; ACTIVATION;
   INCREASES; PATHWAY
AB Renin angiotensin (Ang) system (RAS) activation in metabolic syndrome (MS) patients is associated with elevated uric acid (UA) levels, resulting in endothelial system dysfunction. Our previous study demonstrated that excessive UA could cause endothelial injury through the aldose reductase (AR) pathway. This study is the first to show that a high concentration of Ang II in human umbilical vein endothelial cells (HUVECs) increases reactive oxygen species (ROS) components, including O-2 and H2O2, and further aggravates endothelial system injury induced by high UA (HUA). In a MS/hyperuricemia model, nitric oxide (NO) production was decreased, followed by a decrease in total antioxidant capacity (TAC), and the concentration of the endothelial injury marker von Willebrand factor (vWF) in the serum was increased. Treatment with catalase and polyethylene glycol covalently linked to superoxide dismutase (PEG-SOD) to individually remove H2O2 and O-2 or treatment with the AR inhibitor epalrestat decreased ROS and H2O2, increased NO levels and TAC, and reduced vWF release. Taken together, these data indicate that HUA and Ang II act additively to cause endothelial dysfunction via oxidative stress, and specific elimination of O-2 and H2O2 improves endothelial function. We provide theoretical evidence to prevent or delay endothelial injury caused by metabolic diseases.
C1 [Hong, Quan; Wang, Liyuan; Huang, Zhiyong; Feng, Zhe; Cui, Shaoyuan; Fu, Bo; Cai, Guangyan; Chen, Xiangmei; Wu, Di] Chinese Peoples Liberat Army Gen Hosp, Natl Clin Res Ctr Kidney Dis, State Key Lab Kidney Dis, Dept Nephrol,Chinese PLA Inst Nephrol, Beijing 100853, Peoples R China.
   [Wang, Liyuan] Halison Int Peace Hosp, Kidney Dept, Hengshui City 053000, Peoples R China.
   [Huang, Zhiyong] PLA, Hosp 175, Dept Nephrol, Zhangzhou 036300, Fujian, Peoples R China.
C3 Chinese People's Liberation Army General Hospital
RP Wu, D (corresponding author), Chinese Peoples Liberat Army Gen Hosp, Natl Clin Res Ctr Kidney Dis, State Key Lab Kidney Dis, Dept Nephrol,Chinese PLA Inst Nephrol, Beijing 100853, Peoples R China.
EM redhq@163.com; liyuanwang1986@163.com; hzyonghzy@163.com;
   zhezh_4025@126.com; cshaoyuan@hotmail.com; 824918563@qq.com;
   caiguangyan@sina.com; xmchen301@126.com; wudi@301hospital.com.cn
OI Hong, Quan/0000-0002-6839-7695; Cai, Guang-Yan/0000-0001-8586-6353
FU Chinese National Natural Science Foundation [81870491, 81670694];
   Fostering Fund of Chinese PLA General Hospital for National
   Distinguished Young Scholar Science Fund [2019-JQPY-002]; National Key
   Research and Development Project [2018YFE0126600]; Science and
   Technology Project of Beijing, China [Z191100006619001]
FX This work was supported by the Chinese National Natural Science
   Foundation (Nos. 81870491 and 81670694), the Fostering Fund of Chinese
   PLA General Hospital for National Distinguished Young Scholar Science
   Fund (2019-JQPY-002), the National Key Research and Development Project
   (2018YFE0126600), and the Science and Technology Project of Beijing,
   China (Z191100006619001).
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NR 45
TC 14
Z9 16
U1 2
U2 10
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 0962-9351
EI 1466-1861
J9 MEDIAT INFLAMM
JI Mediat. Inflamm.
PD MAY 22
PY 2020
VL 2020
AR 8387654
DI 10.1155/2020/8387654
PG 11
WC Cell Biology; Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Immunology
GA LU7SE
UT WOS:000537949800001
PM 32565731
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Hu, LF
   Feng, J
   Dai, XL
   Sun, Y
   Xiong, MX
   Lai, LL
   Zhong, SY
   Yi, C
   Chen, G
   Li, HH
   Yang, QF
   Kuang, Q
   Long, TT
   Zhan, JX
   Tang, TT
   Ge, CX
   Tan, J
   Xu, MX
AF Hu, Lin-Feng
   Feng, Jing
   Dai, Xianling
   Sun, Yan
   Xiong, Mingxin
   Lai, Lili
   Zhong, Shaoyu
   Yi, Chao
   Chen, Geng
   Li, Huanhuan
   Yang, Qiufeng
   Kuang, Qin
   Long, Tingting
   Zhan, Jianxia
   Tang, Tingting
   Ge, Chenxu
   Tan, Jun
   Xu, Minxuan
TI Oral flavonoid fisetin treatment protects against prolonged
   high-fat-diet-induced cardiac dysfunction by regulation of multicombined
   signaling
SO JOURNAL OF NUTRITIONAL BIOCHEMISTRY
LA English
DT Article
DE Metabolic syndrome; Fisetin; Insulin resistance and dyslipidemia;
   Tnfr-1/Traf-2; Tgf-beta 1/Smads/Erk1/2
ID NF-KAPPA-B; INSULIN-RESISTANCE; OXIDATIVE STRESS; MATRIX
   METALLOPROTEINASES; CARDIOVASCULAR-DISEASE; HEART-FAILURE; IKK-BETA;
   ACTIVATION; OBESITY; INFLAMMATION
AB Excess high-fat diet (HFD) intake predisposes the occurrence of obesity-associated heart injury, but the mechanism is elusive. Fisetin (FIS), as a natural flavonoid, has potential activities to alleviate obesity-induced metabolic syndrome. However, the underlying molecular mechanisms of FIS against HFD-induced cardiac injury remain unclear. The present study was to explore the protective effects of FIS on cardiac dysfunction in HFD-fed mice. We found that FIS alleviated HFD-triggered metabolic disorder by reducing body weight, fasting blood glucose and insulin levels, and insulin resistance. Moreover, FIS supplements significantly alleviated dyslipidemia in both mouse hearts and cardiomyocytes stimulated by metabolic stress. FIS treatment abolished HFD-induced inflammatory response in heart tissues through suppressing TNF receptor-1/TNF receptor-associated factor-2 (Tnfr-1/Traf-2) signaling. Furthermore, FIS induced a strong reduction in the expression of fibrosis-related genes, contributing to the inhibition of fibrosis by inactivating transforming growth factor (Tgf)-beta 1 / Smads/Erk1/2 signaling. Collectively, these results demonstrated that FIS could be a promising therapeutic strategy for the treatment of obesity-associated cardiac injury. (C) 2019 Elsevier Inc. All rights reserved.
C1 [Hu, Lin-Feng; Feng, Jing; Dai, Xianling; Sun, Yan; Xiong, Mingxin; Lai, Lili; Zhong, Shaoyu; Yi, Chao; Chen, Geng; Li, Huanhuan; Yang, Qiufeng; Kuang, Qin; Long, Tingting; Zhan, Jianxia; Tang, Tingting; Ge, Chenxu; Tan, Jun; Xu, Minxuan] Chongqing Univ Educ, Sch Biol & Chem Engn, Chongqing Key Lab Med Resources Three Gorges Rese, Chongqing 400067, Peoples R China.
   [Hu, Lin-Feng; Feng, Jing; Dai, Xianling; Sun, Yan; Xiong, Mingxin; Lai, Lili; Zhong, Shaoyu; Yi, Chao; Chen, Geng; Li, Huanhuan; Yang, Qiufeng; Kuang, Qin; Long, Tingting; Zhan, Jianxia; Tang, Tingting] Chongqing Univ Educ, Res Ctr Brain Intellectual Promot & Dev Children, Chongqing 400067, Peoples R China.
C3 Chongqing University of Education; Chongqing University of Education
RP Ge, CX; Tan, J; Xu, MX (corresponding author), Chongqing Univ Educ, Sch Biol & Chem Engn, Chongqing Key Lab Med Resources Three Gorges Rese, Chongqing 400067, Peoples R China.
EM gecxsharon@foxmail.com; tanjunmail@126.com; minxuanxu@foxmail.com
RI hu, linfeng/C-6491-2014; Zhong, shaoyu/HNQ-9557-2023; Kuang,
   Q/G-3956-2010
OI Xu, Minxuan/0000-0002-0742-4717; , Xianling/0009-0006-9685-3834
FU National Natural Science Foundation of China (NSFC) [81703527];
   Chongqing Research Program of Basic Research and Frontier Technology
   [cstc2017jcyjAX0356, cstc2018jcyjA3686, cstc2018jcyjAX0784,
   cstc2018jcyjA1472, cstc2018jcyjAX0811, cstc2018jcyjA3533,
   KJZD-M201801601]; School-level Research Program of Chongqing University
   of Education [KY201710B, 17GZKP01]; Advanced Programs of Post-doctor of
   Chongqing [2017LY39]; Science and Technology Research Program of
   Chongqing Education Commission of China [KJQN201901608, KJQN201901615,
   KJ1601402]; Children's Research Institute of National Center for
   Schooling Development Programme [CSDP19FSO1108]; Chongqing University of
   Education [CSDP19FSO1108]
FX This work was jointly supported by (1) National Natural Science
   Foundation of China (NSFC Grant No.: 81703527); (2) Chongqing Research
   Program of Basic Research and Frontier Technology (Grant No.:
   cstc2017jcyjAX0356, cstc2018jcyjA3686, cstc2018jcyjAX0784,
   cstc2018jcyjA1472, cstc2018jcyjAX0811, cstc2018jcyjA3533 and
   KJZD-M201801601); (3) School-level Research Program of Chongqing
   University of Education (Grant No.: KY201710B and 17GZKP01); (4)
   Advanced Programs of Post-doctor of Chongqing (Grant No.: 2017LY39); (5)
   Science and Technology Research Program of Chongqing Education
   Commission of China (Grant No.: KJQN201901608, KJQN201901615, KJ1601402)
   and (6) Children's Research Institute of National Center for Schooling
   Development Programme and Chongqing University of Education (Grant No.:
   CSDP19FSO1108).
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NR 94
TC 19
Z9 19
U1 0
U2 24
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0955-2863
EI 1873-4847
J9 J NUTR BIOCHEM
JI J. Nutr. Biochem.
PD MAR
PY 2020
VL 77
AR 108253
DI 10.1016/j.jnutbio.2019.108253
PG 15
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA KQ4GN
UT WOS:000516883200007
PM 31835147
DA 2025-06-11
ER

PT J
AU Hosoi, T
   Ozawa, K
AF Hosoi, Toru
   Ozawa, Koichiro
TI Possible Pharmacological Approach Targeting Endoplasmic Reticulum Stress
   to Ameliorate Leptin Resistance in Obesity
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Review
DE endoplasmic reticulum stress; obesity; leptin; leptin resistance; STAT3
ID VASCULAR ENDOTHELIAL-CELLS; UNFOLDED PROTEIN RESPONSE;
   TYROSINE-PHOSPHATASE 1B; BLOOD-BRAIN-BARRIER; CONNECTS ER STRESS;
   ENERGY-BALANCE; RECEPTOR; EXPRESSION; NEURONS; MICE
AB Obesity is associated with metabolic syndrome, such as diabetes, hypertension, and hyperlipidemia. Therefore, drug development for the treatment of obesity is needed. Leptin is an anti-obesity hormone that inhibits food intake and increases energy metabolism, and, as such, treatments involving leptin were expected to be beneficial for obesity; however, since most obese patients are in a state of leptin resistance, these treatments may not be useful. Therefore, the amelioration of leptin resistance has recently been attracting interest as a treatment for obesity. The mechanisms underlying the development of leptin resistance need to be elucidated in more detail. Endoplasmic reticulum (ER) stress was recently suggested to be involved in the pathogenesis of leptin resistance. The molecular mechanisms responsible for leptin resistance and possible pharmacological treatments for obesity have been discussed herein, with a focus on ER stress.
C1 [Hosoi, Toru; Ozawa, Koichiro] Hiroshima Univ, Grad Sch Biomed & Hlth Sci, Dept Pharmacotherapy, Hiroshima, Japan.
C3 Hiroshima University
RP Hosoi, T; Ozawa, K (corresponding author), Hiroshima Univ, Grad Sch Biomed & Hlth Sci, Dept Pharmacotherapy, Hiroshima, Japan.
EM toruh@hiroshima-u.ac.jp; ozawak@hiroshima-u.ac.jp
RI Hosoi, Toru/A-7954-2018
FU Ministry of Education, Science, Sports and Culture, Japan; Takeda
   Science Foundation; Grants-in-Aid for Scientific Research [16K08271,
   15K08025] Funding Source: KAKEN
FX This study was supported by a Grant-in-Aid for Scientific Research from
   the Ministry of Education, Science, Sports and Culture, Japan and the
   Takeda Science Foundation.
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NR 47
TC 12
Z9 13
U1 0
U2 14
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA PO BOX 110, EPFL INNOVATION PARK, BUILDING I, LAUSANNE, 1015,
   SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD JUN 8
PY 2016
VL 7
AR 59
DI 10.3389/fendo.2016.00059
PG 4
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA DP5CE
UT WOS:000378512800001
PM 27375555
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Wang, Y
   Fouret, G
   Bonafos, B
   Blachnio-Zabielska, A
   Leroy, T
   Crouzier, D
   Barea, B
   Gaillet, S
   Moro, C
   Lecomte, J
   Coudray, C
   Feillet-Coudray, C
AF Wang, Yang
   Fouret, Gilles
   Bonafos, Beatrice
   Blachnio-Zabielska, Agnieszka
   Leroy, Thibault
   Crouzier, David
   Barea, Bruno
   Gaillet, Sylvie
   Moro, Cedric
   Lecomte, Jerome
   Coudray, Charles
   Feillet-Coudray, Christine
TI Long-term follow-up of muscle lipid accumulation, mitochondrial activity
   and oxidative stress and their relationship with impaired glucose
   homeostasis in high fat high fructose diet-fed rats
SO JOURNAL OF NUTRITIONAL BIOCHEMISTRY
LA English
DT Article
DE Free radicals; High fat/high fructose diet; Impaired glucose
   homeostasis; Mitochondrial function; Muscle lipid composition; Muscle
   metabolism; Oxidative stress
ID STEAROYL-COA DESATURASE; INSULIN-RESISTANCE; SKELETAL-MUSCLE; METABOLIC
   SYNDROME; RESPIRATORY-CHAIN; ACID-COMPOSITION; INDUCED OBESITY;
   SENSITIVITY; LIVER; PHOSPHATIDYLCHOLINE
AB Metabolic syndrome components, including obesity, dyslipidemia and impaired glucose homeostasis, become a major public health issue. Muscles play a predominant role in insulin-mediated glucose uptake, and high fat diets may negatively affect muscle function and homeostasis. This work aimed to study the time-course of muscle lipid accumulation, oxidative stress and mitochondrial dysfunction and their association to impaired glucose homeostasis in rats fed an obesogenic diet. Male Wistar rats were fed with a standard or a high fat/high fructose (HFHFr) diet and sacrificed on 4, 8, 12, 16, 20 weeks. Rats fed the HFHFr diet developed mild overweight, increased liver and adipose tissue weights and glucose intolerance. The impaired glucose homeostasis increased gradually with the HFHFr diet to become significant on the 12th and 16th weeks of diet. In parallel, the muscle lipid composition showed an increase in the saturated fatty acids and the monounsaturated fatty acids with a marked decrease in the polyunsaturated fatty acids. The HFHFr diet also increased muscle contents of both diacylglycerols and Ceramides. Surprisingly, HFHFr diet did not induce major muscle mitochondrial dysfunction or oxidative stress. These results indicate that muscle lipid alterations, as well as impaired glucose homeostasis occur as early as the 8th week of HFHFr diet, increase to reach a plateau around the 12th-16th weeks of diet, and then attenuate towards the end of study. At these diet treatment durations, muscle mitochondrial activity and oxidative stress remained unchanged and do not seem to have a major role in the observed impaired glucose homeostasis. (C) 2018 Elsevier Inc. All rights reserved.
C1 [Wang, Yang; Fouret, Gilles; Bonafos, Beatrice; Gaillet, Sylvie; Coudray, Charles; Feillet-Coudray, Christine] Univ Montpellier, DMEM, INRA, Montpellier, France.
   [Wang, Yang] Zhejiang Univ, Coll Anim Sci, Hangzhou, Zhejiang, Peoples R China.
   [Blachnio-Zabielska, Agnieszka] Med Univ Bialystok, Dept Physiol, Bialystok, Poland.
   [Blachnio-Zabielska, Agnieszka] Med Univ Bialystok, Hyg Epidemiol Metab Disorders Dept, Bialystok, Poland.
   [Leroy, Thibault; Moro, Cedric] INSERM, UMR1048, Inst Metab & Cardiovasc Dis, Toulouse, France.
   [Crouzier, David] Inst Rech Biomed Armees, Paris, France.
   [Barea, Bruno; Lecomte, Jerome] CIRAD, IATE, Montpellier, France.
C3 INRAE; Universite de Montpellier; Zhejiang University; Medical
   University of Bialystok; Medical University of Bialystok; Universite de
   Toulouse; Universite Toulouse III - Paul Sabatier; Institut National de
   la Sante et de la Recherche Medicale (Inserm); CIRAD; Universite de
   Montpellier
RP Feillet-Coudray, C (corresponding author), INRA UMR 866, F-34060 Montpellier, France.
EM christine.coudray@inra.fr
RI Moro, Cedric/N-5754-2017; Blachnio-Zabielsk, Agnieszka/A-4879-2018;
   COUDRAY, Charles/AGG-4757-2022
OI Blachnio-Zabielska, Agnieszka/0000-0002-8055-0576; Moro,
   Cedric/0000-0003-4294-0597
FU PhD program of the China Scholarship Council
FX Yang Wang thanks for the support from PhD program of the China
   Scholarship Council.
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NR 65
TC 9
Z9 10
U1 0
U2 17
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0955-2863
EI 1873-4847
J9 J NUTR BIOCHEM
JI J. Nutr. Biochem.
PD FEB
PY 2019
VL 64
BP 182
EP 197
DI 10.1016/j.jnutbio.2018.10.021
PG 16
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA HL9RZ
UT WOS:000459081600019
PM 30530258
OA Green Published, Bronze, Green Accepted
DA 2025-06-11
ER

PT J
AU Manolagas, SC
   Almeida, M
AF Manolagas, Stavros C.
   Almeida, Maria
TI Gone with the Wnts:: β-catenin, T-cell factor, forkhead box O, and
   oxidative stress in age-dependent diseases of bone, lipid, and glucose
   metabolism
SO MOLECULAR ENDOCRINOLOGY
LA English
DT Review
ID RECEPTOR-RELATED PROTEIN-5; TRANSCRIPTION FACTOR FOXO3A; BODY-MASS
   INDEX; WNT/BETA-CATENIN; MINERAL DENSITY; DIFFERENTIATED OSTEOBLASTS;
   NEGATIVE REGULATOR; DIABETES-MELLITUS; REDOX REGULATION; FRACTURE RISK
AB The Wnt/beta-catenin signaling pathway affects several biological processes ranging from embryonic development, patterning, and postembryonic stem cell fate, to bone formation and insulin secretion in adulthood. beta-Catenin mediates canonical Wnt signaling by binding to and activating members of the T-cell factor ( TCF) transcription factor family. Similar to the Wnt/beta-catenin pathway, oxidative stress influences fundamental cellular processes including stem cell fate and has been linked to aging and the development of age-related diseases. However, the molecular details of the pathogenetic effects of oxidative stress on the homeostasis of many different tissues remain unclear. beta-Catenin has been recently implicated as a pivotal molecule in defense against oxidative stress by serving as a cofactor of the forkhead box O ( FOXO) transcription factors. In addition, it has been shown that oxidative stress is a pivotal pathogenetic factor of age-related bone loss and strength in mice, leading to, among other changes, a decrease in osteoblast number and bone formation. These particular cellular changes evidently result from diversion of the limited pool of beta-catenin from TCF- to FOXO-mediated transcription in osteoblastic cells. Fascinatingly, attenuation of Wnt-mediated transcription, resulting from an autosomal-dominant missense mutation in LRP6, a coreceptor for the Wnt-signaling pathway, has been linked recently genetically not only to premature osteoporosis, but also to coronary artery disease as well as several features of the metabolic syndrome including hyperlipidemia, hypertension, and diabetes, but not obesity. In this minireview, we highlight evidence linking the age-associated oxidative stress with FOXOs, Wnt/beta-catenin signaling, osteoblastogenesis, adipogenesis, osteoporosis, and several features of the metabolic syndrome. We hypothesize that antagonism of Wnt signaling by oxidative stress with increasing age may be a common molecular mechanism contributing to the development not only of involutional osteoporosis, but several pathologies such as atherosclerosis, insulin resistance, and hyperlipidemia, all of which become more prevalent with advancing age.
C1 Univ Arkansas Med Sci, Div Endocrinol & Metab, Little Rock, AR 72205 USA.
   Univ Arkansas Med Sci, Ctr Osteoporosis & Metab Bone Dis, Dept Med, Little Rock, AR 72205 USA.
   Cent Arkansas Vet Hlth Care Syst, Little Rock, AR 72205 USA.
C3 University of Arkansas System; University of Arkansas Medical Sciences;
   University of Arkansas System; University of Arkansas Medical Sciences;
   US Department of Veterans Affairs; Veterans Health Administration (VHA);
   Central Arkansas Veterans Healthcare System
RP Manolagas, SC (corresponding author), 4301 W Markham 587, Little Rock, AR 72205 USA.
EM manolagasstavros@uams.edu
OI Almeida, Maria/0000-0002-6722-9200
FU NIAMS NIH HHS [R01AR51187] Funding Source: Medline; NIA NIH HHS
   [P01AG13918] Funding Source: Medline
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NR 98
TC 278
Z9 318
U1 2
U2 44
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0888-8809
EI 1944-9917
J9 MOL ENDOCRINOL
JI Mol. Endocrinol.
PD NOV
PY 2007
VL 21
IS 11
BP 2605
EP 2614
DI 10.1210/me.2007-0259
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 224JV
UT WOS:000250444200001
PM 17622581
OA Bronze
DA 2025-06-11
ER

PT J
AU Wu, KLH
   Chao, YM
   Tsay, SJ
   Chen, CH
   Chan, SHH
   Dovinova, I
   Chan, JYH
AF Wu, Kay L. H.
   Chao, Yung-Mei
   Tsay, Shiow-Jen
   Chen, Chen Hsiu
   Chan, Samuel H. H.
   Dovinova, Ima
   Chan, Julie Y. H.
TI Role of Nitric Oxide Synthase Uncoupling at Rostral Ventrolateral
   Medulla in Redox-Sensitive Hypertension Associated With Metabolic
   Syndrome
SO HYPERTENSION
LA English
DT Article
DE hypertension; metabolic cardiovascular syndrome; nitric oxide; reactive
   oxygen species; sympathetic nervous system
ID SYMPATHETIC-NERVE ACTIVITY; OXIDATIVE STRESS; AUTONOMIC FUNCTION;
   PROTEIN INHIBITOR; ARCUATE NUCLEUS; UP-REGULATION; ENDOTHELIAL FUNCTION;
   INSULIN-RESISTANCE; ARTERIAL-PRESSURE; NO SYNTHASE
AB Metabolic syndrome (MetS), which is rapidly becoming prevalent worldwide, is long known to be associated with hypertension and recently with oxidative stress. Of note is that oxidative stress in the rostral ventrolateral medulla (RVLM), where sympathetic premotor neurons reside, contributes to sympathoexcitation and hypertension. This study sought to identify the source of tissue oxidative stress in RVLM and their roles in neural mechanism of hypertension associated with MetS. Adult normotensive rats subjected to a high-fructose diet for 8 weeks developed metabolic traits of MetS, alongside increases in sympathetic vasomotor activity and blood pressure. In RVLM of these MetS rats, the tissue level of reactive oxygen species was increased, nitric oxide (NO) was decreased, and mitochondrial electron transport capacity was reduced. Whereas the protein expression of neuronal NO synthase (nNOS) or protein inhibitor of nNOS was increased, the ratio of nNOS dimer/monomer was significantly decreased. Oral intake of pioglitazone or intracisternal infusion of tempol or coenzyme Q(10) significantly abrogated all those molecular events in high-fructose diet-fed rats and ameliorated sympathoexcitation and hypertension. Gene silencing of protein inhibitor of nNOS mRNA in RVLM using lentivirus carrying small hairpin RNA inhibited protein inhibitor of nNOS expression, increased the ratio of nNOS dimer/monomer, restored NO content, and alleviated oxidative stress in RVLM of high-fructose diet-fed rats, alongside significantly reduced sympathoexcitation and hypertension. These results suggest that redox-sensitive and protein inhibitor of nNOS-mediated nNOS uncoupling is engaged in a vicious cycle that sustains the production of reactive oxygen species in RVLM, resulting in sympathoexcitation and hypertension associated with MetS.
C1 [Wu, Kay L. H.; Chao, Yung-Mei; Chan, Samuel H. H.; Chan, Julie Y. H.] Kaohsiung Chang Gung Mem Hosp, Ctr Translat Res Biomed Sci, Kaohsiung 83301, Taiwan.
   [Tsay, Shiow-Jen] Natl Sun Yat Sen Univ, Inst Biol Sci, Kaohsiung 80424, Taiwan.
   [Chen, Chen Hsiu] Kaohsiung Vet Gen Hosp, Dept Anesthesiol, Kaohsiung, Taiwan.
   [Dovinova, Ima] Slovak Acad Sci, Inst Normal & Pathol Physiol, Bratislava, Slovakia.
C3 Chang Gung Memorial Hospital; National Sun Yat Sen University; Kaohsiung
   Veterans General Hospital; Slovak Academy of Sciences; Institute of
   Normal & Pathological Physiology, SAS
RP Chan, JYH (corresponding author), Kaohsiung Chang Gung Mem Hosp, Ctr Translat Res Biomed Sci, Kaohsiung 83301, Taiwan.
EM Ima.Dovinova@savba.sk; jchan@adm.cgmh.org.tw
RI Dovinova, Ima/F-2449-2018; Wu, Kay/ACD-1767-2022; Chan,
   Julie/X-5253-2019
OI DOVINOVA, IMA/0000-0001-9840-1950; Wu, Kay L.H./0000-0002-7297-6788
FU National Science Council [NSC100-2923-B-182A-001-MY3,
   NSC102-2321-B-182A-003]; Chang Gung Medical Foundation, Taiwan; Slovak
   Academy of Sciences, Slovakia [SAS-NSC JRP 2010/1]
FX This work was supported in part by research grants
   NSC100-2923-B-182A-001-MY3 and NSC102-2321-B-182A-003 (J.Y.H. Chan) from
   the National Science Council, CMRPG8C0051 (J.Y.H. Chan) from the Chang
   Gung Medical Foundation, Taiwan, and SAS-NSC JRP 2010/1 (I. Dovinova)
   from the Slovak Academy of Sciences, Slovakia.
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NR 65
TC 32
Z9 38
U1 0
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0194-911X
EI 1524-4563
J9 HYPERTENSION
JI Hypertension
PD OCT
PY 2014
VL 64
IS 4
BP 815
EP +
DI 10.1161/HYPERTENSIONAHA.114.03777
PG 26
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA AP3PB
UT WOS:000341988000021
PM 24958506
DA 2025-06-11
ER

PT J
AU Medford, HM
   Chatham, JC
   Marsh, SA
AF Medford, H. M.
   Chatham, J. C.
   Marsh, S. A.
TI Chronic ingestion of a Western diet increases
   O-linked-β-N-acetylglucosamine (O-GlcNAc) protein modification in the
   rat heart
SO LIFE SCIENCES
LA English
DT Article
DE Western diet; saturated fat; O-GlcNAc; cardiac metabolism
ID HIGH-FAT DIET; IMPROVES CONTRACTILE FUNCTION; METABOLIC SYNDROME;
   CARDIOMYOCYTE DYSFUNCTION; CARDIAC-HYPERTROPHY; OBESITY; GLCNACYLATION;
   ACTIVATION; CONTRIBUTES; PREVALENCE
AB Aims: Protein O-GlcNAcylation is both a nutrient sensing and cellular stress response that mediates signal transduction in the heart. Chronically elevated O-GlcNAc has been associated with the development of cardiac dysfunction at both the cellular and organ levels in obesity, insulin resistance and diabetes. Development of these pathologies is often attributed to diets high in saturated fat and sugar (a "Western" diet; WES) but a role for O-GlcNAc in diet-induced cardiac dysfunction has not been established. The aims of this study were to examine the effect of chronic consumption of WES on cardiac O-GlcNAcylation and investigate associations of O-GlcNAc with cardiac function and markers of cellular stress.
   Main methods: Young male rats received either a control diet (CON; n = 9) or WES (n = 8) diet for 52 weeks.
   Key findings: There was no evidence of cardiac dysfunction, advanced glycation endproduct (AGE) accumulation, pathological cardiac hypertrophy, calcium handling impairment, fibrosis or endoplasmic reticulum stress in WES hearts. However, cardiac O-GlcNAc protein, particularly in the higher molecular weight range, was significantly higher in WES hearts compared to CON (P<0.05). Protein levels of the enzymes that regulate O-GlcNAc attachment were not different between groups; thus, the increased O-GlcNAcylation in WES hearts appears to be due to increased nutrient availability rather than enzymatic regulation of cellular stress.
   Significance: These data suggest that diets high in saturated fat and sugar may contribute to the adverse effects of metabolic syndrome and diabetes by an O-GlcNAc-mediated process and that this may occur in the absence of overt cellular stress. (c) 2012 Elsevier Inc. All rights reserved.
C1 [Marsh, S. A.] Washington State Univ, Coll Pharm, Program Nutr & Exercise Physiol, Spokane, WA 99210 USA.
   [Medford, H. M.] Washington State Univ, Coll Pharm, Grad Program Nutr & Exercise Physiol, Spokane, WA 99210 USA.
   [Chatham, J. C.] Univ Alabama Birmingham, Dept Pathol, Div Mol & Cellular Pathol, Birmingham, AL USA.
C3 Washington State University; Washington State University; University of
   Alabama System; University of Alabama Birmingham
RP Marsh, SA (corresponding author), Washington State Univ, Coll Pharm, Program Nutr & Exercise Physiol, POB 1495, Spokane, WA 99210 USA.
EM samarsh@wsu.edu
RI Marsh, Sue/J-3711-2014
OI Chatham, John/0000-0001-7180-9948
FU National Institute of Health [HL-104549, HL-77100, HL-67464, HL-101192];
   WSU College of Pharmacy
FX This work was supported by National Institute of Health grants
   (HL-104549 to SAM and HL-77100, HL-67464, HL-101192 to JCC) and the WSU
   College of Pharmacy (SAM). We are grateful for the technical support
   provided by Charlye A. Brocks, W. Eddie Bradley and Dr. Karen Porter.
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NR 33
TC 38
Z9 43
U1 0
U2 10
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0024-3205
EI 1879-0631
J9 LIFE SCI
JI Life Sci.
PD JUN 14
PY 2012
VL 90
IS 23-24
BP 883
EP 888
DI 10.1016/j.lfs.2012.04.030
PG 6
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA 962LO
UT WOS:000305546800001
PM 22575823
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Colldén, G
   Tschöp, MH
   Müller, TD
AF Collden, Gustav
   Tschoep, Matthias H.
   Mueller, Timo D.
TI Therapeutic Potential of Targeting the Ghrelin Pathway
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE ghrelin; therapy; pathology; inflammation; anorexia
ID DES-ACYL GHRELIN; ACUTE LUNG INJURY; HORMONE SECRETAGOGUE RECEPTOR;
   DIET-INDUCED OBESITY; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; INDUCED
   PULMONARY-HYPERTENSION; ANOREXIA-CACHEXIA SYNDROME; SPINAL-CORD
   MOTONEURONS; VENTRAL TEGMENTAL AREA; STIMULATES FOOD-INTAKE
AB Ghrelin was discovered in 1999 as the endogenous ligand of the growth-hormone secretagogue receptor 1a (GHSR1a). Since then, ghrelin has been found to exert a plethora of physiological effects that go far beyond its initial characterization as a growth hormone (GH) secretagogue. Among the numerous well-established effects of ghrelin are the stimulation of appetite and lipid accumulation, the modulation of immunity and inflammation, the stimulation of gastric motility, the improvement of cardiac performance, the modulation of stress, anxiety, taste sensation and reward-seeking behavior, as well as the regulation of glucose metabolism and thermogenesis. Due to a variety of beneficial effects on systems' metabolism, pharmacological targeting of the endogenous ghrelin system is widely considered a valuable approach to treat metabolic complications, such as chronic inflammation, gastroparesis or cancer-associated anorexia and cachexia. The aim of this review is to discuss and highlight the broad pharmacological potential of ghrelin pathway modulation for the treatment of anorexia, cachexia, sarcopenia, cardiopathy, neurodegenerative disorders, renal and pulmonary disease, gastrointestinal (GI) disorders, inflammatory disorders and metabolic syndrome.
C1 [Collden, Gustav; Tschoep, Matthias H.; Mueller, Timo D.] German Res Ctr Environm Hlth GmbH, Helmholtz Zentrum Munchen, Inst Diabet & Obes, D-85764 Neuherberg, Germany.
   [Collden, Gustav; Tschoep, Matthias H.; Mueller, Timo D.] German Res Ctr Environm Hlth GmbH, Helmholtz Zentrum Munchen, Helmholtz Diabet Ctr, D-85764 Neuherberg, Germany.
   [Tschoep, Matthias H.] Tech Univ Munich, Div Metab Dis, Dept Med, D-80333 Munich, Germany.
   [Mueller, Timo D.] Inst Diabet & Obes, Business Campus Garching Hochbruck,Parkring 13, D-85748 Garching, Germany.
C3 Helmholtz Association; Helmholtz-Center Munich - German Research Center
   for Environmental Health; Helmholtz Association; Helmholtz-Center Munich
   - German Research Center for Environmental Health; Technical University
   of Munich
RP Müller, TD (corresponding author), German Res Ctr Environm Hlth GmbH, Helmholtz Zentrum Munchen, Inst Diabet & Obes, D-85764 Neuherberg, Germany.; Müller, TD (corresponding author), German Res Ctr Environm Hlth GmbH, Helmholtz Zentrum Munchen, Helmholtz Diabet Ctr, D-85764 Neuherberg, Germany.; Müller, TD (corresponding author), Inst Diabet & Obes, Business Campus Garching Hochbruck,Parkring 13, D-85748 Garching, Germany.
EM gustav.collden@helmholtz-muenchen.de;
   matthias.tschoep@helmholtz-muenchen.de;
   timo.mueller@helmholtz-muenchen.de
RI Müller, Timo/AAZ-4445-2020; Tschoep, Matthias/I-5443-2014
OI Muller, Timo/0000-0002-0624-9339
FU Alexander von Humboldt Foundation; Helmholtz Alliance Imaging and Curing
   Environmental Metabolic Diseases (ICEMED); Helmholtz Initiative on
   Personalized Medicine iMed by the Helmholtz Association; Helmholtz
   cross-program topic "Metabolic Dysfunction"; German Research Foundation
   [DFG-TS226/1-1, DFG-TS226/3-1, SFB1123]; European Research Council ERC
   AdG HypoFlam [695054]
FX This work was supported in part by funding from the Alexander von
   Humboldt Foundation, the Helmholtz Alliance Imaging and Curing
   Environmental Metabolic Diseases (ICEMED) and the Helmholtz Initiative
   on Personalized Medicine iMed by the Helmholtz Association and the
   Helmholtz cross-program topic "Metabolic Dysfunction". This work was
   further supported by grants from the German Research Foundation
   DFG-TS226/1-1, DFG-TS226/3-1, SFB1123, and the European Research Council
   ERC AdG HypoFlam No. 695054. The figures were made by using material
   from Servier Medical Art (Servier) under consideration of a Creative
   Commons Attribution 3.0 Unported License, as well as material from
   Wikimedia Commons. Timo D. Muller and Gustav Collden have no conflicts
   of interest, financial or otherwise. Matthias H. Tschop is a scientific
   advisor for Novo Nordisk, Bionorica SE and Erx Biotech.
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NR 300
TC 113
Z9 125
U1 2
U2 36
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD APR
PY 2017
VL 18
IS 4
AR 798
DI 10.3390/ijms18040798
PG 29
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA EW6SA
UT WOS:000402639400122
PM 28398233
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Luciano, TF
   de Souza, CT
   de Oliveira, J
   Müller, AP
AF Luciano, Thais Fernandes
   Teodoro de Souza, Claudio
   de Oliveira, Jade
   Mueller, Alexandre Pastoris
TI Reversal of high-fat diet-induced cognitive impairment and oxidative
   stress in the brain through Zingiber officinale supplementation
SO METABOLIC BRAIN DISEASE
LA English
DT Article
DE Zingiber officinale; Learning and memory; Obesity; Brain metabolism
ID INDUCED NEUROINFLAMMATION; METABOLIC SYNDROME; GINGER; OBESITY; EXTRACT;
   ANXIETY; IMPACT; MICE
AB Obesity is a significant health concern that is correlated with various adverse health outcomes. Diet-induced obesity (DIO) is associated with impaired cognitive function. Pharmacological treatments for obesity are limited and may have serious adverse effects. Zingiber officinale (ZO) has anti-inflammatory and antioxidant effects, in addition to metabolic effects. This study aimed to assess the effects of Zingiber officinale supplementation on cognitive function, anxiety levels, neurotrophin levels, and the inflammatory and oxidative status in the cortex following DIO in mice. Two-month-old male Swiss mice were fed DIO or standard chow for 4 months and subsequently subdivided into the following groups (n = 10 mice/group): (i) control - vehicle (CNT + vehicle); (ii) CNT supplemented with ZO (CNT + ZO); (iii) obese mice (DIO + vehicle); and (iv) obese mice supplemented with ZO (DIO + ZO) (n = 10). Zingiber officinale extract (400 mg/kg/day) was administered for 35 days via oral gavage. The DIO + vehicle group exhibited impaired recognition memory. The CNT + ZO group presented a greater number of crossings in the open field. No difference between the groups was observed in the plus maze test. DIO + vehicle increased the DCFH and carbonylation levels in the cortex. The DIO + vehicle group presented a reduction in catalase activity. The expression of inflammatory or neurotrophin markers in the cerebral cortex was not different. In conclusion, our findings indicate that supplementation with ZO reverses the cognitive impairment in DIO mice and enhances the antioxidant status of the cerebral cortex.
C1 [Luciano, Thais Fernandes] Univ Extremo Catarinense UNESC, Postgrad Program Hlth Sci, Criciuma, SC, Brazil.
   [Teodoro de Souza, Claudio] Fed Univ Juiz Fora UFJF, Med Sch, Dept Internal Med, Postgrad Program Hlth, Juiz De Fora, MG, Brazil.
   [de Oliveira, Jade] Univ Fed Rio Grande UFRGS, Dept Bioquim, Programa Pos Grad Ciencias Biologicas: Bioquim, Inst Ciencias Bas Saude ICBS, Porto Alegre, RS, Brazil.
   [Mueller, Alexandre Pastoris] Fed Univ Santa Catarina UFSC, Dept Biochem, Postgrad Program Biochem, Florianopolis, SC, Brazil.
   [Mueller, Alexandre Pastoris] Fed Univ Santa Catarina UFSC, Postgrad Program Pharmacol, Florianopolis, SC, Brazil.
C3 Universidade Federal de Juiz de Fora; Universidade Federal do Rio Grande
   do Sul; Universidade Federal de Santa Catarina (UFSC); Universidade
   Federal de Santa Catarina (UFSC)
RP Müller, AP (corresponding author), Fed Univ Santa Catarina UFSC, Dept Biochem, Postgrad Program Biochem, Florianopolis, SC, Brazil.
EM bionutrithais@gmail.com; claudio.t.desouza@gmail.com;
   deoliveirajade10@gmail.com; alexandrep.muller@gmail.com
RI de Oliveira, Jade/AAJ-6849-2020
OI Muller, alexandre/0000-0002-9961-8614
FU Conselho Nacional de Desenvolvimento Cientfico e Tecnolgico
FX No Statement Available
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NR 51
TC 1
Z9 1
U1 3
U2 5
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0885-7490
EI 1573-7365
J9 METAB BRAIN DIS
JI Metab. Brain Dis.
PD DEC
PY 2024
VL 39
IS 8
BP 1495
EP 1503
DI 10.1007/s11011-024-01406-8
EA AUG 2024
PG 9
WC Endocrinology & Metabolism; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology
GA L1N6T
UT WOS:001288063700001
PM 39120852
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Koenig, G
   Seneff, S
AF Koenig, Gerald
   Seneff, Stephanie
TI Gamma-Glutamyltransferase: A Predictive Biomarker of Cellular
   Antioxidant Inadequacy and Disease Risk
SO DISEASE MARKERS
LA English
DT Review
ID CHRONIC KIDNEY-DISEASE; SERUM FERRITIN LEVELS; FATTY LIVER-DISEASE;
   YOUNG-ADULTS; METABOLIC SYNDROME; OXIDATIVE-STRESS;
   CARDIOVASCULAR-DISEASE; KOREAN MEN; INSULIN-RESISTANCE; CANCER INCIDENCE
AB Gamma-glutamyltransferase (GGT) is a well-established serum marker for alcohol-related liver disease. However, GGT's predictive utility applies well beyond liver disease: elevated GGT is linked to increased risk to a multitude of diseases and conditions, including cardiovascular disease, diabetes, metabolic syndrome (MetS), and all-cause mortality. The literature from multiple population groups worldwide consistently shows strong predictive power for GGT, even across different gender and ethnic categories. Here, we examine the relationship of GGT to other serum markers such as serum ferritin (SF) levels, and we suggest a link to exposure to environmental and endogenous toxins, resulting in oxidative and nitrosative stress. We observe a general upward trend in population levels of GGT over time, particularly in the US and Korea. Since the late 1970s, both GGT and incident MetS and its related disorders have risen in virtual lockstep. GGT is an early predictive marker for atherosclerosis, heart failure, arterial stiffness and plaque, gestational diabetes, and various liver diseases, including viral hepatitis, other infectious diseases, and several life-threatening cancers. We review literature both from the medical sciences and from life insurance industries demonstrating that serum GGT is a superior marker for future disease risk, when compared against multiple other known mortality risk factors.
C1 [Koenig, Gerald] Hlth E Iron LLC, Austin, TX 78746 USA.
   [Koenig, Gerald] Iron Disorders Inst, Greenville, SC 29615 USA.
   [Seneff, Stephanie] MIT, Comp Sci & Artificial Intelligence Lab, Cambridge, MA 02139 USA.
C3 Massachusetts Institute of Technology (MIT)
RP Koenig, G (corresponding author), Hlth E Iron LLC, 2800 Waymaker Way 12, Austin, TX 78746 USA.
EM gerrykoenigtx@aol.com
OI Seneff, Stephanie/0000-0001-8191-1049
FU Quanta Computers, Taipei, Taiwan, under the auspices of the Qmulus
   Project
FX This research was funded in part by Quanta Computers, Taipei, Taiwan,
   under the auspices of the Qmulus Project.
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NR 103
TC 228
Z9 243
U1 2
U2 30
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 0278-0240
EI 1875-8630
J9 DIS MARKERS
JI Dis. Markers
PY 2015
VL 2015
BP 1
EP 18
AR 818570
DI 10.1155/2015/818570
PG 18
WC Biotechnology & Applied Microbiology; Genetics & Heredity; Medicine,
   Research & Experimental; Pathology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Genetics & Heredity; Research &
   Experimental Medicine; Pathology
GA CU5UA
UT WOS:000363596300001
PM 26543300
OA Green Published, hybrid, Green Submitted
DA 2025-06-11
ER

PT J
AU Coccurello, R
   D'Amato, FR
   Moles, A
AF Coccurello, Roberto
   D'Amato, Francesca R.
   Moles, Anna
TI Chronic social stress, hedonism and vulnerability to obesity: Lessons
   from Rodents
SO NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
LA English
DT Review
DE Social stress; Food intake; Reward; CART; Obesity; Rodents
ID AMPHETAMINE-REGULATED TRANSCRIPT; CORTICOTROPIN-RELEASING-FACTOR;
   11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1; PITUITARY-ADRENAL AXIS;
   INDUCED BEHAVIORAL SENSITIZATION; NEONATAL MATERNAL SEPARATION; HEPATIC
   INSULIN SENSITIVITY; COCAINE-SEEKING BEHAVIOR; NUCLEUS-ACCUMBENS SHELL;
   LONG-EVANS RATS
AB Obesity is a current health pandemia. Determinants of this pathology are rather complex and include genetic, developmental and environmental factors only partially disclosed. Stress related neuroendocrine dysregulation and overconsumption of high palatable high caloric food and are likely to contribute to this modern health threats. Despite the evidence that psychosocial stress is one of the main sources of stress in humans and may play an important role in the development of the stress disorders, including obesity and metabolic syndrome, animal models focusing on the relationship between chronic stress and energy homeostasis are scattered and most of them encompasses physical rather than psychosocial stress. Aim of the present paper is to review rodent studies on the effect of psychosocial stress throughout life on body weight and food intake regulation. In the second part of the review special focus will be given on the mechanisms linking stress and the reward system. (C) 2008 Elsevier Ltd. All rights reserved.
C1 [Coccurello, Roberto; D'Amato, Francesca R.; Moles, Anna] CNR, Inst Neurosci, I-00143 Rome, Italy.
C3 Consiglio Nazionale delle Ricerche (CNR)
RP Moles, A (corresponding author), CNR, Inst Neurosci, Via Fosso di Fiorano 64-65, I-00143 Rome, Italy.
EM anna.moles@ipsifar.rm.cnr.it
RI Coccurello, Roberto/F-8460-2015
OI Moles, Anna/0000-0002-5805-5763; D'Amato, Francesca/0000-0002-4577-4574;
   COCCURELLO, ROBERTO/0000-0001-7059-7015
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NR 216
TC 63
Z9 73
U1 0
U2 20
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0149-7634
EI 1873-7528
J9 NEUROSCI BIOBEHAV R
JI Neurosci. Biobehav. Rev.
PD APR
PY 2009
VL 33
IS 4
SI SI
BP 537
EP 550
DI 10.1016/j.neubiorev.2008.05.018
PG 14
WC Behavioral Sciences; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Behavioral Sciences; Neurosciences & Neurology
GA 431ST
UT WOS:000265084700006
PM 18585781
DA 2025-06-11
ER

PT J
AU Fandos, M
   Corella, D
   Guillén, M
   Portolés, O
   Carrasco, P
   Iradi, A
   Martínez-González, MA
   Estruch, R
   Covas, MI
   Lamuela-Raventós, RM
   Michavilla, MT
   Cerdá, C
   Torregrosa, R
   Redón, J
   Chaves, FF
   Tormos, MC
   Ocete, D
   Sáez, GT
AF Fandos, Marta
   Corella, Dolores
   Guillen, Marisa
   Portoles, Olga
   Carrasco, Paula
   Iradi, Antonio
   Martinez-Gonzalez, Miguel A.
   Estruch, Ramon
   Covas, Maria I.
   Maria Lamuela-Raventos, Rosa
   Teresa Michavilla, Maria
   Cerda, Concha
   Torregrosa, Rafael
   Redon, Josep
   Felipe Chaves, Francisco
   Carmen Tormos, M.
   Ocete, Dolores
   Saez, Guillermo T.
CA Predimed Grp
TI Impact of cardiovascular risk factors on oxidative stress and DNA damage
   in a high risk Mediterranean population
SO FREE RADICAL RESEARCH
LA English
DT Article
DE Oxidative stress; 8-oxo-dG; cardiovascular risk factors; hypertension;
   primary prevention
ID CORONARY-HEART-DISEASE; METABOLIC SYNDROME; ANTIOXIDANT ACTIVITIES;
   PLASMA-LEVELS; BY-PRODUCTS; DIET; ATHEROSCLEROSIS; GLUTATHIONE;
   EXPRESSION; RESISTANCE
AB The impact of classic cardiovascular risk factors on oxidative stress status in a high-risk cardiovascular Mediterranean population of 527 subjects was estimated. Oxidative stress markers (malondialdehyde, 8-oxo-7'8'-dihydro-2'-deoxyguanosine, oxidized/reduced glutathione ratio) together with the activity of antioxidant enzyme triad (superoxide dismutase, catalase, glutathione peroxidase) were analysed in circulating mononuclear blood cells. Malondialdehyde, oxidized glutathione and the ratio of oxidized to reduced glutathione were significantly higher while catalase and glutathione peroxidase activities were significantly lower in high cardiovascular risk participants than in controls. Statistically significant differences were obtained after additional multivariate control for sex, age, obesity, diabetes, lipids and medications. Among the main cardiovascular risk factors, hypertension was the strongest determinant of oxidative stress in high risk subjects studied at a primary prevention stage.
C1 [Fandos, Marta; Carmen Tormos, M.; Saez, Guillermo T.] Univ Valencia, Fac Med, Dept Biochem & Mol Biol, Avda Blasco Ibanez 15, Valencia, Spain.
   [Corella, Dolores; Guillen, Marisa; Portoles, Olga; Carrasco, Paula] Univ Valencia, Sch Med, Dept Prevent Med, Valencia, Spain.
   [Corella, Dolores; Estruch, Ramon; Covas, Maria I.] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr, Madrid, Spain.
   [Iradi, Antonio] Univ Valencia, Fac Med, Dept Physiol, Valencia, Spain.
   [Martinez-Gonzalez, Miguel A.] Univ Navarra, Dept Prevent Med & Publ Hlth, Navarra, Spain.
   [Estruch, Ramon] Hosp Clin Barcelona, Dept Internal Med, Barcelona, Spain.
   [Covas, Maria I.] Municipal Inst Med Res IMIM, Cardiovasc Epidemiol Unit, Barcelona, Spain.
   [Maria Lamuela-Raventos, Rosa] Sch Pharm, Dept Nutr & Bromatol, Barcelona, Spain.
   [Teresa Michavilla, Maria] Univ Barcelona, Dept Physiol, Diagonal, Spain.
   [Cerda, Concha; Torregrosa, Rafael] Gen Univ Hosp, Clin Anal Serv, Patras, Greece.
   [Redon, Josep] Univ Valencia, Hypertens Unit, Serv Internal Med, Clin Univ Hosp, Valencia, Spain.
   [Felipe Chaves, Francisco] Clin Univ Hosp Valencia, Fdn Res, Valencia, Spain.
   [Ocete, Dolores] Univ Valencia, Microbiol Unit C, Valencia, Spain.
   [Saez, Guillermo T.] Univ Valencia, Gen Univ Hosp, Fac Med, Dept Biochem & Mol Biol, Valencia, Spain.
C3 University of Valencia; University of Valencia; CIBER - Centro de
   Investigacion Biomedica en Red; CIBEROBN; Instituto de Salud Carlos III;
   University of Valencia; University of Navarra; University of Barcelona;
   Hospital Clinic de Barcelona; Hospital del Mar Research Institute;
   University of Barcelona; University of Valencia; University of Valencia;
   University of Valencia
RP Sáez, GT (corresponding author), Univ Valencia, Fac Med, Dept Biochem & Mol Biol, Avda Blasco Ibanez 15, Valencia, Spain.
EM guillermo.saez@uv.es
RI Corella, Dolores/L-9888-2014; Martinez-Gonzalez, Miguel/AAE-7669-2019;
   CHAVES, FELIPE/ABC-3294-2021; Estruch, Ramon/AAZ-3723-2020; Redon,
   Josep/L-5997-2019; Marisa, Guillén/AAJ-8250-2020; Lamuela-Raventos, Rosa
   M/F-3986-2016; Carrasco, Paula/D-7864-2019
OI Lamuela-Raventos, Rosa M/0000-0002-1287-4560; Carrasco,
   Paula/0000-0002-7170-4318; CHAVES, FELIPE J/0000-0001-8009-3689; Saez,
   Guillermo/0000-0002-8164-4048; Redon, Josep/0000-0001-8777-6773;
   Martinez-Gonzalez, Miguel A./0000-0002-3917-9808; Marisa,
   Guillen/0000-0001-5802-6316
FU Instituto de Salud Carlos III [FIS PI070240, PI052368, PI051458,
   PI042234, RD06/0045/0006, CIBER06/03]; Conselleria de Sanitat Valencia
   [GRUPOS 03/101, GRUPOS2004-43, ACOMP06109]
FX Sources of Funding: Instituto de Salud Carlos III (FIS PI070240,
   PI052368, PI051458, PI042234, RD06/0045/0006 and CIBER06/03);
   Conselleria de Sanitat Valencia (GRUPOS 03/101, GRUPOS2004-43 and
   ACOMP06109).
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NR 44
TC 16
Z9 16
U1 0
U2 5
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1071-5762
EI 1029-2470
J9 FREE RADICAL RES
JI Free Radic. Res.
PY 2009
VL 43
IS 12
BP 1179
EP 1186
DI 10.3109/10715760903247231
PG 8
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 532MP
UT WOS:000272753100004
PM 19905980
DA 2025-06-11
ER

PT J
AU Chen, R
   Qi, QL
   Wang, MT
   Li, QY
AF Chen, Rui
   Qi, Qiao-Ling
   Wang, Meng-Ting
   Li, Qi-Yan
TI Therapeutic potential of naringin: an overview
SO PHARMACEUTICAL BIOLOGY
LA English
DT Article
DE Pharmacological action; bone regeneration; anti-inflammatory;
   anti-cancer; extraction technology; controlled release formulations
ID MITOCHONDRIA-MEDIATED APOPTOSIS; NF-KAPPA-B; OXIDATIVE STRESS;
   TOXICOLOGICAL EVALUATION; INDUCED OSTEOPOROSIS; METABOLIC SYNDROME;
   CITRUS FLAVONOIDS; FRUCTUS AURANTII; BONE-RESORPTION; RAT PLASMA
AB Context: Naringin is a natural flavanone glycoside that is found in the Chinese herbal medicines and citrus fruits. Studies have demonstrated that naringin possesses numerous biological and pharmacological properties, but few reviews of these studies have been performed.
   Objective: The present review gathers the fragmented information available in the literature describing the extraction of naringin, its pharmacology and its controlled release formulations. Current research progress and the therapeutic potential of naringin are also discussed.
   Methods: A literature survey for relevant information regarding the biological and pharmacological properties of naringin was conducted using Pubmed, Sciencedirect, MEDLINE, Springerlink and Google Scholar electronic databases from the year 2007-2015.
   Results: Naringin modulates signalling pathways and interacts with signalling molecules and thus has a wide range of pharmacological activities, including anti-inflammatory, anti-cancer activities, as well as effects on bone regeneration, metabolic syndrome, oxidative stress, genetic damage and central nervous system (CNS) diseases. Information was gathered that showed the extraction of naringin can be improved using several modifications. There has been some progress in the development of controlled release formulations of naringin.
   Conclusion: Naringin is a promising candidate for further in vivo studies and clinical use. More detailed studies regarding its mechanism of action are required.
C1 [Chen, Rui; Wang, Meng-Ting; Li, Qi-Yan] Kunming Univ Sci & Technol, Fac Med, Kunming, Yunnan, Peoples R China.
   [Chen, Rui; Wang, Meng-Ting; Li, Qi-Yan] First Peoples Hosp Yunnan Prov, Kunming 650032, Yunnan, Peoples R China.
   [Chen, Rui; Wang, Meng-Ting; Li, Qi-Yan] Univ Sci & Technol Kunming, Affiliated Hosp Ctr, Kunming, Yunnan, Peoples R China.
   [Qi, Qiao-Ling] Dali Univ, Yunnan Prov Key Lab Entomol Biopharmaceut R, Dali, Yunnan, Peoples R China.
C3 Kunming University of Science & Technology; Kunming University of
   Science & Technology; Dali University
RP Li, QY (corresponding author), Kunming Univ Sci & Technol, Fac Med, Kunming, Yunnan, Peoples R China.; Li, QY (corresponding author), First Peoples Hosp Yunnan Prov, Kunming 650032, Yunnan, Peoples R China.; Li, QY (corresponding author), Univ Sci & Technol Kunming, Affiliated Hosp Ctr, Kunming, Yunnan, Peoples R China.
EM ynliqiyan@aliyun.com
FU National Scientific Foundation of China under the National Scientific
   Grant [81160134]; Yunnan Provincial Science and Technology Department
   under the Grant Talent Reserve of Young Academic and Technical Leaders
   of Yunnan Province [2012HB027]; Yunnan Provincial Bureau of Health under
   the Grant Medical Academic Leaders of Yunnan Province [D-201232]
FX This work was supported by the National Scientific Foundation of China
   under the National Scientific Grant [grant number 81160134]; by the
   Yunnan Provincial Science and Technology Department under the Grant
   Talent Reserve of Young Academic and Technical Leaders of Yunnan
   Province [grant number 2012HB027]; and by the Yunnan Provincial Bureau
   of Health under the Grant Medical Academic Leaders of Yunnan Province
   [grant number D-201232].
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NR 69
TC 285
Z9 306
U1 14
U2 162
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1388-0209
EI 1744-5116
J9 PHARM BIOL
JI Pharm. Biol.
PD DEC
PY 2016
VL 54
IS 12
BP 3203
EP 3210
DI 10.1080/13880209.2016.1216131
PG 8
WC Plant Sciences; Medical Laboratory Technology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Medical Laboratory Technology; Pharmacology & Pharmacy
GA EE2VN
UT WOS:000389443300053
PM 27564838
OA Bronze
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Lubrano, C
   Valacchi, G
   Specchia, P
   Gnessi, L
   Rubanenko, EP
   Shuginina, EA
   Trukhanov, AI
   Korkina, LG
   De Luca, C
AF Lubrano, Carla
   Valacchi, Giuseppe
   Specchia, Palma
   Gnessi, Lucio
   Rubanenko, Elizaveta P.
   Shuginina, Elena A.
   Trukhanov, Arseny I.
   Korkina, Liudmila G.
   De Luca, Chiara
TI Integrated Haematological Profiles of Redox Status, Lipid, and
   Inflammatory Protein Biomarkers in Benign Obesity and Unhealthy Obesity
   with Metabolic Syndrome
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Article
ID LOW-GRADE INFLAMMATION; ADIPOSE-TISSUE EXPRESSION;
   NECROSIS-FACTOR-ALPHA; FATTY LIVER-DISEASE; OXIDATIVE STRESS; VITAMIN-E;
   SIGNALING PATHWAYS; LINKING OBESITY; WEIGHT-LOSS; GLUTATHIONE
AB The pathogenesis of obesity (OB) and metabolic syndrome (MetS) implies free radical-, oxidized lipid- (LOOH-), and inflammatory cytokine-mediated altered pathways in target organs. Key elements of the transition from benign OB to unhealthy OB+MetS remain unclear. Here, we measured a panel of redox, antioxidant, and inflammation markers in the groups of OB patients (67 with, 45 without MetS) and 90 controls. Both OB groups displayed elevated levels of adipokines and heavy oxidative stress (OS) evidenced by reduced levels of glutathione, downregulated glutathione-S-transferase, increased 4-hydroxynonenal-protein adducts, reactive oxygen species, and membrane-bound monounsaturated fatty acids (MUFA). Exclusively in OB+MetS, higher-than-normal glutathione peroxidase activity, tumor necrosis factor-alpha, and other proinflammatory cytokines/chemokines/growth factors were observed; a combination of high adipokine plasminogen activator inhibitor-1 and MUFA was consistent with increased cardiovascular risk. The uncomplicated OB group showed features of adaptation to OS such as decreased levels of vitamin E, activated superoxide dismutase, and inhibited catalase, suggesting H2O2 hyperproduction. Proinflammatory cytokine pattern was normal, except few markers like RANTES, a suitable candidate for therapeutic approaches to prevent a setting of MetS by inhibition of LOOH-primed leukocyte chemotaxis/recruitment to target tissues.
C1 [Lubrano, Carla; Specchia, Palma; Gnessi, Lucio] Univ Roma La Sapienza, Policlin Umberto 1, Dept Expt Med, Sect Med Pathophysiol Endocrinol & Food Sci, I-00161 Rome, Italy.
   [Valacchi, Giuseppe] Univ Ferrara, Dept Life Sci & Biotechnol, I-44100 Ferrara, Italy.
   [Valacchi, Giuseppe] Kyung Hee Univ, Dept Food & Nutr, Seoul 130701, South Korea.
   [Rubanenko, Elizaveta P.; Shuginina, Elena A.; Trukhanov, Arseny I.; Korkina, Liudmila G.] Act Longev Clin, Inst Krasoty Arbate, Moscow 119002, Russia.
   [Korkina, Liudmila G.; De Luca, Chiara] Cibi NanoLab, Ctr Innovat Biotechnol Invest, Moscow 119571, Russia.
C3 Sapienza University Rome; University Hospital Sapienza Rome; University
   of Ferrara; Kyung Hee University
RP De Luca, C (corresponding author), Cibi NanoLab, Ctr Innovat Biotechnol Invest, 197 Vernadskogo Prospekt, Moscow 119571, Russia.
EM deluca@cibi-nanolab.com
RI Gnessi, Lucio/K-8025-2016; Shuginina, Elena/AAH-6995-2019; Trukhanov,
   Arseniy/AAV-6037-2020
OI Gnessi, Lucio/0000-0001-8217-2372
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NR 99
TC 10
Z9 10
U1 0
U2 3
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PY 2015
VL 2015
AR 490613
DI 10.1155/2015/490613
PG 14
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA CK5TF
UT WOS:000356287900001
PM 26090072
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU So, JS
   Chung, KM
   Seo, J
   Kim, B
   Chun, H
   Han, SN
   Chung, IM
AF So, Jisun
   Chung, Kyong-Mee
   Seo, Jihyeon
   Kim, Byungmi
   Chun, Hyejin
   Han, Sung Nim
   Chung, Ick-Mo
TI High intake of sweet foods and low life satisfaction can act as risk
   factors for acute coronary syndrome through synergistic interaction
SO FRONTIERS IN NUTRITION
LA English
DT Article
DE coronary artery disease; sweets; life satisfaction; diet; psychology
ID SOFT DRINK CONSUMPTION; METABOLIC SYNDROME; CARDIOVASCULAR-DISEASE;
   BEVERAGE CONSUMPTION; COFFEE CONSUMPTION; NATIONAL-HEALTH; MORTALITY;
   REHABILITATION; ASSOCIATION; DEPRESSION
AB PurposeDietary and psychological status contributes to the development of coronary artery disease. However, these lifestyle factors may vary depending on ethnic and environmental background, and secondary prevention programs dealing with these factors in a specific population are not well-established. We aimed to assess dietary and psychological characteristics in Korean patients with acute coronary syndrome (ACS) and analyze their interactions as independent risk factors for ACS. MethodsNinety-two patients with ACS (29 acute myocardial infarction and 63 unstable angina) and 69 controls were subjected to dietary and psychological analyses. Dietary intake was assessed by a food frequency questionnaire. Psychological depression and perceived stress were assessed using the Patient Health Questionnaire-9 and the Perceived Stress Scale, respectively. Eight domains of life satisfaction (marital/love relationship, leisure, standard of living, job, health, family life, sex life, and self) were assessed using the Domain Satisfaction Questionnaire (DSQ). ResultsThe ACS group had a higher consumption of sweets and fish/seafood, as well as higher levels of depressive symptoms. Additionally, they had lower DSQ scores in total, and all eight individual domains compared with the control group. In multivariate logistic regression analysis, sweet intake (OR 4.57, 95% CI: 1.94-11.40) and total DSQ scores (OR 0.34, 95% CI: 0.14-0.81) were identified as independent risk factors for ACS. Furthermore, these factors, which displayed a significant inverse correlation (& rho; = -0.23, p = 0.01), were determined as having a synergistic contribution to the development of ACS. ConclusionHigh sweet food intake and low life satisfaction can act as risk factors for ACS through a synergistic interaction, which emphasizes a demand for a more comprehensive approach to secondary prevention of ACS. In addition, these data highlight the role of positive psychological wellbeing factors in cardiovascular health.
C1 [So, Jisun; Han, Sung Nim] Seoul Natl Univ, Coll Human Ecol, Dept Food & Nutr, Seoul, South Korea.
   [Chung, Kyong-Mee; Seo, Jihyeon] Yonsei Univ, Dept Psychol, Seoul, South Korea.
   [Kim, Byungmi] Natl Canc Ctr, Natl Canc Control Inst, Div Canc Prevent, Goyang Si, South Korea.
   [Chun, Hyejin] Ewha Womans Univ, Mokdong Hosp, Dept Family Med, Sch Med, Seoul, South Korea.
   [Han, Sung Nim] Seoul Natl Univ, Res Inst Human Ecol, Seoul, South Korea.
   [Chung, Ick-Mo] Ewha Womans Univ, Mokdong Hosp, Div Cardiol, Sch Med, Seoul, South Korea.
C3 Seoul National University (SNU); Yonsei University; National Cancer
   Center - Korea (NCC); Ewha Womans University; Seoul National University
   (SNU); Ewha Womans University
RP Han, SN (corresponding author), Seoul Natl Univ, Coll Human Ecol, Dept Food & Nutr, Seoul, South Korea.; Han, SN (corresponding author), Seoul Natl Univ, Res Inst Human Ecol, Seoul, South Korea.; Chung, IM (corresponding author), Ewha Womans Univ, Mokdong Hosp, Div Cardiol, Sch Med, Seoul, South Korea.
EM snhan@snu.ac.kr; ickmo@ewha.ac.kr
OI Chung, Il-Moon/0000-0003-0163-7305
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NR 57
TC 1
Z9 1
U1 0
U2 0
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD AUG 7
PY 2023
VL 10
AR 1221916
DI 10.3389/fnut.2023.1221916
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA P4WV7
UT WOS:001050691100001
PM 37609484
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Mak, KK
   Kong, WY
   Mak, A
   Sharma, VK
   Ho, RCM
AF Mak, Kwok Kei
   Kong, Wan Yee
   Mak, Anselm
   Sharma, Vijay Kumar
   Ho, Roger C. M.
TI Polymorphisms of the serotonin transporter gene and post-stroke
   depression: a meta-analysis
SO JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
LA English
DT Article
ID PROMOTER POLYMORPHISM; PROLACTIN RESPONSE; METABOLIC SYNDROME;
   LIFE-STRESS; 5-HTTLPR; ASSOCIATION; REGION; DISORDERS; RECEPTORS
AB Background Polymorphisms of the gene encoding the serotonin transporter-specifically, length variation in the serotonin-transporter-linked polymorphic region (5-HTTLPR), a single-nucleotide polymorphism in the 5-HTTLPR (rs25531), and variable number of tandem repeats (VNTR) in the second intron 2 (STin2)-have been implicated in the development of post-stroke depression (PSD).
   Objective To evaluate the association between polymorphisms of the serotonin transporter gene and PSD in the medical literature.
   Methods Random-effects meta-analyses were conducted on cross-sectional, case-control and cohort studies examining relations between polymorphisms of the gene encoding the serotonin transporter and the risk of developing PSD.
   Results Four studies comprising 260 stroke patients with PSD and 381 without were included. Our analyses showed a significant and positive association between the homozygous short variation (S) allele genotype of the 5-HTTLPR (SS) and PSD (random-effects pooled OR 2.05, 95% CI 1.41 to 2.98, z=3.79, p<0.001). Our analyses also showed a significant and negative association between the homozygous long variation (L) allele genotype of the 5-HTTLPR (LL) and PSD (random-effects OR 0.52, 95% CI 0.27 to 0.97, z=-2.07, p=0.039). No statistically significant association of PSD with heterozygous S and L allele genotype for 5-HTTLPR or other polymorphisms with rs25531 and STin2 VNTR was found. Heterogeneity and publication bias were not statistically significant. The major limitation of this meta-analysis is that we could not assess the interaction between stroke, environmental stress and PSD.
   Conclusions The 5-HTTLPR SS genotype may be a risk factor for PSD. The 5-HTTLPR LL genotype showed a significant negative association with PSD. Further research to assess the sensitivity and specificity of predicting the risk of developing PSD by screening for the 5-HTTLPR genotype in stroke patients is required.
C1 [Mak, Kwok Kei] Univ Hong Kong, Dept Community Med, Hong Kong, Hong Kong, Peoples R China.
   [Mak, Kwok Kei] Univ Hong Kong, Sch Publ Hlth, Hong Kong, Hong Kong, Peoples R China.
   [Kong, Wan Yee; Ho, Roger C. M.] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Psychol Med, Singapore 119228, Singapore.
   [Mak, Anselm; Sharma, Vijay Kumar] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Med, Singapore 119228, Singapore.
C3 University of Hong Kong; University of Hong Kong; National University of
   Singapore; National University of Singapore
RP Ho, RCM (corresponding author), Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Psychol Med, Level 9 NUHS Tower Block,1E Kent Ridge Rd, Singapore 119228, Singapore.
EM pcmrhcm@nus.edu.sg
RI Ho, Roger/ABD-9061-2021; sharma, Vijay/A-6733-2009
OI sharma, Vijay/0000-0002-8976-5696
CR Anguelova M, 2003, MOL PSYCHIATR, V8, P646, DOI 10.1038/sj.mp.4001336
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NR 40
TC 60
Z9 66
U1 0
U2 25
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 0022-3050
EI 1468-330X
J9 J NEUROL NEUROSUR PS
JI J. Neurol. Neurosurg. Psychiatry
PD MAR
PY 2013
VL 84
IS 3
BP 322
EP 328
DI 10.1136/jnnp-2012-303791
PG 7
WC Clinical Neurology; Psychiatry; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Psychiatry; Surgery
GA 091HY
UT WOS:000315041400019
PM 23236014
DA 2025-06-11
ER

PT J
AU Martin, FPJ
   Montoliu, I
   Collino, S
   Scherer, M
   Guy, P
   Tavazzi, I
   Thorimbert, A
   Moco, S
   Rothney, MP
   Ergun, DL
   Beaumont, M
   Ginty, F
   Qanadli, SD
   Favre, L
   Giusti, V
   Rezzi, S
AF Martin, Francois-Pierre J.
   Montoliu, Ivan
   Collino, Sebastiano
   Scherer, Max
   Guy, Philippe
   Tavazzi, Isabelle
   Thorimbert, Anita
   Moco, Sofia
   Rothney, Megan P.
   Ergun, David L.
   Beaumont, Maurice
   Ginty, Fiona
   Qanadli, Salah D.
   Favre, Lucie
   Giusti, Vittorio
   Rezzi, Serge
TI Topographical Body Fat Distribution Links to Amino Acid and Lipid
   Metabolism in Healthy Non-Obese Women
SO PLOS ONE
LA English
DT Article
ID ADIPOSE-TISSUE; CARDIOVASCULAR-DISEASE; CARDIOMETABOLIC RISK; PLATELET
   ACTIVATION; INSULIN-RESISTANCE; OXIDATIVE STRESS; CENTRAL OBESITY;
   ABDOMINAL FAT; PLASMALOGENS; POPULATION
AB Visceral adiposity is increasingly recognized as a key condition for the development of obesity related disorders, with the ratio between visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) reported as the best correlate of cardiometabolic risk. In this study, using a cohort of 40 obese females (age: 25-45 y, BMI: 28-40 kg/m(2)) under healthy clinical conditions and monitored over a 2 weeks period we examined the relationships between different body composition parameters, estimates of visceral adiposity and blood/urine metabolic profiles. Metabonomics and lipidomics analysis of blood plasma and urine were employed in combination with in vivo quantitation of body composition and abdominal fat distribution using iDXA and computerized tomography. Of the various visceral fat estimates, VAT/SAT and VAT/total abdominal fat ratios exhibited significant associations with regio-specific body lean and fat composition. The integration of these visceral fat estimates with metabolic profiles of blood and urine described a distinct amino acid, diacyl and ether phospholipid phenotype in women with higher visceral fat. Metabolites important in predicting visceral fat adiposity as assessed by Random forest analysis highlighted 7 most robust markers, including tyrosine, glutamine, PC-O 44: 6, PC-O 44: 4, PC-O 42: 4, PC-O 40: 4, and PC-O 40: 3 lipid species. Unexpectedly, the visceral fat associated inflammatory profiles were shown to be highly influenced by inter-days and between-subject variations. Nevertheless, the visceral fat associated amino acid and lipid signature is proposed to be further validated for future patient stratification and cardiometabolic health diagnostics.
C1 [Martin, Francois-Pierre J.; Collino, Sebastiano; Scherer, Max; Guy, Philippe; Tavazzi, Isabelle; Thorimbert, Anita; Moco, Sofia; Rezzi, Serge] Nestec Ltd, Nestle Res Ctr, Metabol & Biomarkers, CH-1000 Lausanne, Switzerland.
   [Montoliu, Ivan] Nestec Ltd, Nestle Res Ctr, Appl Math, CH-1000 Lausanne, Switzerland.
   [Rothney, Megan P.] GE Global Res Ctr, Diagnost & Biomed Technol Org, Niskayuna, NY USA.
   [Ergun, David L.; Ginty, Fiona] GE Healthcare, Madison, WI USA.
   [Beaumont, Maurice] Nestec Ltd, Nestle Res Ctr, Clin Dev Unit, CH-1000 Lausanne, Switzerland.
   [Qanadli, Salah D.] Univ Lausanne Hosp, Dept Radiol, Cardiothorac & Vasc Unit, Lausanne, Switzerland.
   [Favre, Lucie; Giusti, Vittorio] Univ Lausanne Hosp, Dept Med, Serv Endocrinol Diabetol & Metab, Lausanne, Switzerland.
C3 Nestle SA; Nestle Research Center; Nestle SA; Nestle Research Center;
   General Electric; General Electric; Nestle SA; Nestle Research Center;
   University of Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV);
   University of Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV)
RP Martin, FPJ (corresponding author), Nestle Inst Hlth Sci SA, Mol Biomarkers, Lausanne, Switzerland.
EM francois-pierre.martin@rd.nestle.com; serge.rezzi@rd.nestle.com
RI Moco, Sofia/AAN-7187-2021
OI Guy, philippe/0000-0002-2968-8625; QANADLI, Salah
   Dine/0000-0003-1330-660X; Martin, Francois-Pierre/0000-0003-1373-5367;
   Moco, Sofia/0000-0001-8170-8876; Ginty, Fiona/0000-0001-6638-683X;
   Rezzi, Serge/0000-0002-0691-2153
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NR 63
TC 38
Z9 40
U1 1
U2 16
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD SEP 11
PY 2013
VL 8
IS 9
AR e73445
DI 10.1371/journal.pone.0073445
PG 14
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 248VW
UT WOS:000326734500032
PM 24039943
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Gunduz, G
   Beler, M
   Unal, I
   Cansiz, D
   Emekli-Alturfan, E
   Kose, KN
AF Gunduz, Gizem
   Beler, Merih
   Unal, Ismail
   Cansiz, Derya
   Emekli-Alturfan, Ebru
   Kose, Kemal Naci
TI Gingipain Injection Affects Intestinal Oxidant- Antioxidant Status and
   Alkaline Phosphatase in Overfed Zebrafish
SO EXPERIMED
LA English
DT Article
DE Gingipain; zebrafish; oxidative stress
ID PORPHYROMONAS-GINGIVALIS; LIPID-PEROXIDATION; METABOLIC SYNDROME;
   OXIDATIVE STRESS; PERIODONTITIS
AB Objective: Porphyromonas gingivalis ( P. gingivalis), ), a major periodontopathogen, is associated with overfeeding disorders, including metabolic syndrome. Gingipains are one of the most powerful endotoxins of P. gingivalis. . Our aim was to reveal the effects of gingipain injections on the intestinal oxidant-antioxidant status and alkaline phosphatase (ALP) activity in overfed zebrafish. Materials and Methods: Four groups of healthy adult zebrafish were placed in random tanks as C: Control (n=15); GP: Gingipain (n=15); OF: Overfeeding (n=15); and OF+GP: Overfeeding+Gingipain (n=15) groups. At the end of the experiment, levels of intestinal lipid peroxidation (LPO) and ALP, glutathione S-transferase (GST), and catalase (CAT) activities were evaluated. Results: Intestinal LPO was significantly lower in the GP and OF groups compared to C. Gingipain injection in OF (OF+GP) significantly elevated LPO when compared to C, GP, and OF groups. ALP activities decreased significantly in the GP, OF, and OF+GP compared to C. GST activities increased significantly in the GP when compared to C. Decreased GST activities were observed in the OF and OF+GP. This decrease was less in OF+GP. CAT activities significantly decreased in all groups when compared to C. Conclusion: Our findings demonstrate that gingipain injection alters the ALP activity and intestinal oxidant-antioxidant status in overfed zebrafish.
C1 [Gunduz, Gizem] Marmara Univ, Inst Hlth Sci, Dept Periodontol, Istanbul, Turkiye.
   [Beler, Merih; Unal, Ismail] Marmara Univ, Inst Hlth Sci, Dept Biochem, Istanbul, Turkiye.
   [Cansiz, Derya] Istanbul Medipol Univ, Fac Med, Dept Biochem, Istanbul, Turkiye.
   [Emekli-Alturfan, Ebru] Marmara Univ, Fac Dent, Dept Biochem, Nisantasi, Turkiye.
   [Kose, Kemal Naci] Marmara Univ, Fac Dent, Dept Periodontol, Istanbul, Turkiye.
C3 Marmara University; Marmara University; Istanbul Medipol University;
   Marmara University; Marmara University
RP Kose, KN (corresponding author), Marmara Univ, Fac Dent, Dept Periodontol, Istanbul, Turkiye.
EM kemkose@superonline.com
RI CANSIZ, Derya/ABF-7508-2020; Emekli-Alturfan, Ebru/X-2758-2019; Kose,
   Kemal/AAA-1941-2019; Ünal, İsmail/GPG-1965-2022
FU Marmara University Scientific Research and Project Commission
   [TDK-2021-10420]
FX This project was supported by Marmara University Scientific Research and
   Project Commission, Project No: TDK-2021-10420.
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NR 28
TC 2
Z9 2
U1 0
U2 1
PU ISTANBUL UNIV
PI ISTANBUL
PA Rektorlugu, Beyazit, Fatih, ISTANBUL, 34452, Turkiye
EI 2667-5846
J9 EXPERIMED
JI Experimed
PY 2023
VL 13
IS 2
BP 80
EP 85
DI 10.26650/experimed.1268503
PG 6
WC Medicine, Research & Experimental
WE Emerging Sources Citation Index (ESCI)
SC Research & Experimental Medicine
GA H2Y5X
UT WOS:001322146800002
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Chang, YT
   Lin, HC
   Chang, WN
   Tsai, NW
   Huang, CC
   Wang, HC
   Kung, CT
   Su, YJ
   Lin, WC
   Cheng, BC
   Su, CM
   Chen, TY
   Chiang, YF
   Lu, CH
AF Chang, Ya-Ting
   Lin, Hsin-Ching
   Chang, Wen-Neng
   Tsai, Nai-Wen
   Huang, Chih-Cheng
   Wang, Hung-Chen
   Kung, Chia-Te
   Su, Yu-Jih
   Lin, Wei-Che
   Cheng, Ben-Chung
   Su, Chih-Min
   Chen, Ting-Yao
   Chiang, Yi-Fang
   Lu, Cheng-Hsien
TI Impact of inflammation and oxidative stress on carotid intima-media
   thickness in obstructive sleep apnea patients without metabolic syndrome
SO JOURNAL OF SLEEP RESEARCH
LA English
DT Article
DE atherosclerotic disease; endothelium; inflammatory; polysomnography;
   sleep disorder
ID INTERCELLULAR-ADHESION MOLECULE-1; ARTERY INTIMA; INTERMITTENT HYPOXIA;
   PRACTICE PARAMETERS; P-SELECTIN; ATHEROSCLEROSIS; SEVERITY; DISEASE;
   MARKERS; STROKE
AB Obstructive sleep apnea (OSA) increases the risk of cardiovascular diseases, and carotid intima-media thickness (IMT) is a good indicator of the severity of atherosclerotic disease. This study tested the hypothesis that inflammation and oxidative stress determined carotid IMT in patients with OSA. The carotid IMT, mean systolic and diastolic pressure (night and morning) were significantly higher and the level of thiols and highdensity lipoprotein were significantly lower in our 121 OSA patients than in 27 controls (P < 0.05). The apnea/hypopnea index was correlated positively with E-selectin (r = 0.222, P = 0.014), total cholesterol (r = 0.185, P = 0.042), low-density lipoprotein (r = 0.264, P = 0.003) and HbA1c levels (r = 0.304, P = 0.001), but inversely with high-density lipoprotein level (r = -0.203, P = 0.025) in the 121 patients with OSA. In OSA subjects, multiple linear regression analysis revealed that age, systolic blood pressure and intercellular cell adhesion molecule-1 level associated independently with carotid IMT. Besides both age and systolic blood pressure, our study demonstrated that intercellular cell adhesion molecule-1 level was associated significantly with carotid IMT in those patients who had OSA but without metabolic syndrome.
C1 [Chang, Ya-Ting; Chang, Wen-Neng; Tsai, Nai-Wen; Huang, Chih-Cheng; Chen, Ting-Yao; Lu, Cheng-Hsien] Chang Gung Univ Coll Med, Kaohsiung Med Ctr, Chang Gung Mem Hosp, Dept Neurol, Kaohsiung, Taiwan.
   [Chang, Ya-Ting; Chiang, Yi-Fang] Pingtung Christian Hosp, Neurol Sect, Dept Med, Pingtung, Taiwan.
   [Lin, Hsin-Ching] Chang Gung Univ Coll Med, Kaohsiung Med Ctr, Chang Gung Mem Hosp, Dept Otolaryngol, Kaohsiung, Taiwan.
   [Lin, Hsin-Ching] Chang Gung Univ Coll Med, Kaohsiung Med Ctr, Chang Gung Mem Hosp, Sleep Ctr, Kaohsiung, Taiwan.
   [Wang, Hung-Chen] Chang Gung Univ Coll Med, Kaohsiung Med Ctr, Chang Gung Mem Hosp, Dept Neurosurg, Kaohsiung, Taiwan.
   [Kung, Chia-Te; Su, Chih-Min] Chang Gung Univ Coll Med, Kaohsiung Med Ctr, Chang Gung Mem Hosp, Dept Emergency Med, Kaohsiung, Taiwan.
   [Su, Yu-Jih; Cheng, Ben-Chung] Chang Gung Univ Coll Med, Kaohsiung Med Ctr, Chang Gung Mem Hosp, Dept Med, Kaohsiung, Taiwan.
   [Lin, Wei-Che] Chang Gung Univ Coll Med, Kaohsiung Med Ctr, Chang Gung Mem Hosp, Dept Radiol, Kaohsiung, Taiwan.
   [Cheng, Ben-Chung; Lu, Cheng-Hsien] Natl Sun Yat Sen Univ, Dept Biol Sci, Kaohsiung, Taiwan.
   [Lu, Cheng-Hsien] Xiamen Chang Gung Mem Hosp, Dept Neurol, Xiamen, Peoples R China.
C3 Chang Gung University; Chang Gung Memorial Hospital; Chang Gung
   University; Chang Gung Memorial Hospital; Chang Gung Memorial Hospital;
   Chang Gung University; Chang Gung University; Chang Gung Memorial
   Hospital; Chang Gung Memorial Hospital; Chang Gung University; Chang
   Gung Memorial Hospital; Chang Gung University; Chang Gung Memorial
   Hospital; Chang Gung University; National Sun Yat Sen University
RP Lu, CH (corresponding author), Chang Gung Mem Hosp, Dept Neurol, 123 Ta Pei Rd, Kaohsiung, Taiwan.
EM chlu99@ms44.url.com.tw
RI Huang, Chien-Lung/O-2028-2013; Chang, Ya-Ting/E-1761-2012; wang,
   yichun/IXW-7812-2023; Chaou, Chung-Hsien/AAZ-7344-2020; Su,
   Yu-Jih/AGJ-4763-2022
OI Su, Yu-Jih/0000-0002-7274-3458
FU National Research Program for Biopharmaceuticals
   [101-2314-B-182A-084-MY3, 104-2314-B-182A-028-MY2]
FX This study was supported by grants from the National Research Program
   for Biopharmaceuticals (101-2314-B-182A-084-MY3,
   104-2314-B-182A-028-MY2).
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NR 39
TC 13
Z9 16
U1 0
U2 9
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0962-1105
EI 1365-2869
J9 J SLEEP RES
JI J. Sleep Res.
PD APR
PY 2017
VL 26
IS 2
BP 151
EP 158
DI 10.1111/jsr.12477
PG 8
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA EQ4ZO
UT WOS:000398090400006
PM 27896929
DA 2025-06-11
ER

PT J
AU Hopps, E
   Lo Presti, R
   Montana, M
   Canino, B
   Averna, MR
   Caimi, G
AF Hopps, E.
   Lo Presti, R.
   Montana, M.
   Canino, B.
   Averna, M. R.
   Caimi, G.
TI Study of the Correlations among Some Parameters of the Oxidative Status,
   Gelatinases, and Their Inhibitors in a Group of Subjects with Metabolic
   Syndrome
SO MEDIATORS OF INFLAMMATION
LA English
DT Article
ID MATRIX-METALLOPROTEINASE EXPRESSION; NITRIC-OXIDE; TISSUE INHIBITOR;
   INSULIN-RESISTANCE; PROTEIN OXIDATION; HIGH GLUCOSE;
   MATRIX-METALLOPROTEINASE-9; STRESS; HYPERTENSION; PEROXYNITRITE
AB Our aim was to examine some parameters of oxidative status, gelatinases, and their inhibitors and to evaluate their interrelationships in subjects with metabolic syndrome (MS). We enrolled 65 MS subjects, subdivided according to the presence or not of diabetes mellitus. We examined lipid peroxidation (expressed as thiobarbituric acid reacting substances, TBARS), protein oxidation (expressed as carbonyl groups), nitric oxide metabolites (NOx), total antioxidant status (TAS), MMP-2, MMP-9, TIMP-1, and TIMP-2. We found that MS subjects, diabetics and nondiabetics, showed an increase in TBARS, PC, and NOx. A significant decrease in TAS was observed only in nondiabetic MS subjects in comparison with diabetic MS subjects. We observed increased concentrations of MMP-2, MMP-9, TIMP-1, and TIMP-2, higher in diabetic subjects. Our data showed a positive correlation between TAS and MMP-2, TAS and MMP-9, and TAS and MMP-9/TIMP-1 and a negative correlation between TBARS and MMP-2 in diabetic MS subjects in the entire group. In MS subjects a prooxidant status and increased levels of gelatinases and their inhibitors are evident although the correlations between oxidative stress and MMPs or TIMPs are controversial and need further investigation.
C1 [Hopps, E.; Lo Presti, R.; Montana, M.; Canino, B.; Averna, M. R.; Caimi, G.] Univ Palermo, Dipartimento Biomed Med Interna & Specialist, I-90100 Palermo, Italy.
C3 University of Palermo
RP Hopps, E (corresponding author), Univ Palermo, Dipartimento Biomed Med Interna & Specialist, Via Vespro 129, I-90100 Palermo, Italy.
EM eugenia.hopps@unipa.it
RI Montaña, Fernanda/ADG-6031-2022; Averna, Maurizio/U-9527-2017; LO
   PRESTI, Rosalia/J-5394-2016
OI Averna, Maurizio/0000-0003-3558-9209; LO PRESTI,
   Rosalia/0000-0002-7491-568X; canino, baldassare/0000-0001-6024-331X;
   Caimi, Gregorio/0000-0001-8964-255X
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NR 60
TC 8
Z9 8
U1 0
U2 2
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 0962-9351
EI 1466-1861
J9 MEDIAT INFLAMM
JI Mediat. Inflamm.
PY 2014
VL 2014
AR 510619
DI 10.1155/2014/510619
PG 7
WC Cell Biology; Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Immunology
GA AL5ZY
UT WOS:000339213100001
PM 25114377
OA gold, Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Stellato, D
   Morrone, LF
   Di Giorgio, C
   Gesualdo, L
AF Stellato, Davide
   Morrone, Luigi Francesco
   Di Giorgio, Chiara
   Gesualdo, Loreto
TI Uric acid: a starring role in the intricate scenario of metabolic
   syndrome with cardio-renal damage?
SO INTERNAL AND EMERGENCY MEDICINE
LA English
DT Review
DE Uric acid; Oxidative stress; Endothelial disfunction; Inflammatory
   response
ID CHRONIC KIDNEY-DISEASE; BLOOD-PRESSURE; RISK-FACTOR; HYPERURICEMIA;
   HYPERTENSION; OBESITY
AB Elevated uric acid levels are a common finding in patients with metabolic syndrome and in those with cardiovascular and renal disease, but the meaning of this elevation is still unclear. In patients with chronic kidney diseases, it could merely reflect the reduction in glomerular filtration rate: but uric acid levels are known to be elevated in people, also in younger ones, prior to the development of hypertension or renal disease, independently of several risk factors. Multiple potential mechanisms suggest a causative role for uric acid in vascular disease. Uric acid has been shown to be involved in metabolic pathways that lead to oxidative stress, endothelial disfunction, and to a vascular and systemic inflammatory response. Moreover, the elevation in uric acid levels observed after fructose ingestion, with a consequent reduction in nitric oxide, may lead to a reduced glucose uptake in the skeletal muscle, hyperinsulinemia, and insulin resistance. Besides these bench research data, also clinical studies showed the beneficial effects of lowering uric acid therapies on several markers of cardiovascular and renal disease. To date, however, there is no evidence indicating that such therapies, that are not free of risk, may reduce cardiovascular events; so that to manage our prescriptions, we need larger, prospective, interventional data.
C1 [Di Giorgio, Chiara; Gesualdo, Loreto] Azienda Osped Univ OO RR, Foggia, Italy.
   [Stellato, Davide; Morrone, Luigi Francesco] Azienda Osped Rummo, Benevento, Italy.
RP Gesualdo, L (corresponding author), Azienda Osped Univ OO RR, Foggia, Italy.
EM l.gesualdo@altanet.it
RI MORRONE, Luigi Francesco Pio/ACH-0379-2022; Gesualdo, Loreto/K-7751-2016
OI MORRONE, Luigi Francesco Pio/0000-0002-1126-0719; Gesualdo,
   Loreto/0000-0002-4861-0911
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NR 36
TC 18
Z9 18
U1 0
U2 10
PU SPRINGER-VERLAG ITALIA SRL
PI MILAN
PA VIA DECEMBRIO, 28, MILAN, 20137, ITALY
SN 1828-0447
EI 1970-9366
J9 INTERN EMERG MED
JI Intern. Emerg. Med.
PD FEB
PY 2012
VL 7
IS 1
BP 5
EP 8
DI 10.1007/s11739-011-0642-3
PG 4
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 881WO
UT WOS:000299522300003
PM 21842242
DA 2025-06-11
ER

PT J
AU Chellappan, D
   Joseph, J
   Shabi, MM
   Krishnamoorthy, G
   Ravindhran, D
   Uthrapathy, S
   Rajamanickam, VG
   Dubey, GP
AF Chellappan, Davidraj
   Joseph, Jipnomon
   Shabi, Mohamed M.
   Krishnamoorthy, Gayathri
   Ravindhran, Dhevi
   Uthrapathy, Subashini
   Rajamanickam, Victor G.
   Dubey, Govindha P.
TI Psycho-emotional stress - A cause of coronary artery disease
SO ACTA SCIENTIAE VETERINARIAE
LA English
DT Article
DE Lipid Profile; Oxidative Stress; Hung Stress; Rabbit; Lipid Peroxidation
ID LOW-DENSITY-LIPOPROTEIN; LIPID-PEROXIDATION; GLUTATHIONE-PEROXIDASE;
   CELL-DAMAGE; RESTRAINT; PLASMA; ASSAY
AB Psycho-emotional stress is one of the risk factors for metabolic syndrome and related diseases. Hence, this study has designed to the effect of psycho-emotional stress in the form of immobilization stress in rabbits. In this study, we used 12 male New Zealand White rabbits (2.5-3 kg body weight), Six animals for hanging fixation and another six as control. Blood samples were taken before hanging (0 minute) and at 60, 120 minutes. Serum was separated and used for the estimation of various biochemical parameters. Hanging fixation appears to produce significant increase in malondialdehyde and lipid profile levels. The non-enzymatic antioxidants like reduced glutathione, vitamin E and ceruloplasmin were found to be decrease and the level of enzymatic antioxidant like glutathione peroxidase was increased significantly. The results reveal that the hanging fixation may develop coronary artery disease. This is the area, which should be evaluated further by carrying out chronic studies in hung stress and by histopathological studies.
C1 [Chellappan, Davidraj; Joseph, Jipnomon; Shabi, Mohamed M.; Krishnamoorthy, Gayathri; Ravindhran, Dhevi; Uthrapathy, Subashini; Rajamanickam, Victor G.; Dubey, Govindha P.] SASTRA Univ, Ctr Adv Res Indian Syst Med, Thanjavur, India.
C3 Shanmugha Arts, Science, Technology & Research Academy (SASTRA)
RP Rajamanickam, VG (corresponding author), SASTRA Univ, Ctr Adv Res Indian Syst Med, Thanjavur, India.
EM vrajamanickam@yahoo.com
RI Chellappan, David/AAN-1373-2020; Uthirapathy, Subasini/L-6097-2017
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NR 30
TC 1
Z9 1
U1 0
U2 0
PU UNIV FED RIO GRANDE DO SUL
PI PORTO ALEGRE RS
PA FAC VET, CAIXA POSTAL 15017, PORTO ALEGRE RS, 91501-570, BRAZIL
SN 1678-0345
EI 1679-9216
J9 ACTA SCI VET
JI Acta Sci. Vet.
PY 2008
VL 36
IS 2
BP 133
EP 139
PG 7
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA 470ZV
UT WOS:000268022100007
DA 2025-06-11
ER

PT J
AU Sodhi, K
   Srikanthan, K
   Goguet-Rubio, P
   Nichols, A
   Nawab, A
   Shah, PT
   Chaudhry, M
   El-Hamdani, M
   Xie, ZJ
   Shapiro, JI
AF Sodhi, Komal
   Srikanthan, Krithika
   Goguet-Rubio, Perrine
   Nichols, Alexandra
   Nawab, Athar
   Shah, Preeya T.
   Chaudhry, Muhammad
   El-Hamdani, Mehiar
   Xie, Zijian
   Shapiro, Joseph I.
TI Inhibition of Na/K-ATPase signaling attenuates steatohepatitis and
   atherosclerosis in mice fed a western diet
SO CELLULAR AND MOLECULAR BIOLOGY
LA English
DT Article
DE Na; K-ATPase signaling; obesity; oxidative stress; inflammation;
   steatohepatitis; atherosclerosis
ID FATTY LIVER-DISEASE; OXIDATIVE STRESS; METABOLIC SYNDROME; HEPATIC
   STEATOSIS; GENE-EXPRESSION; NA+/K+-ATPASE; PATHOGENESIS; IDENTIFICATION;
   INVOLVEMENT; FIBROSIS
AB We have previously reported that the alpha 1 subunit of sodium-potassium adenosine triphosphatase (Na/K-ATPase), acts as a receptor and an amplifier for reactive oxygen species, in addition to its distinct pumping function. On this background, we speculated that the blockade of Na/K-ATPase-induced ROS amplification with a specific peptide, pNaKtide, might attenuate the development of steatohepatitis. To test this hypothesis, pNaKtide was administered to a murine model of NASH: the C57Bl6 mouse fed a "western" diet containing high amounts of fat and fructose. The administration of pNaKtide reduced obesity as well as hepatic steatosis, inflammation and fibrosis. Of interest, we also noted a marked improvement in mitochondrial fatty acid oxidation, insulin sensitivity, dyslipidemia and aortic streaking in this mouse model. To further elucidate the effects of pNaKtide on atherosclerosis, similar studies were performed in ApoE knockout mice also exposed to the western diet. In these mice, pNaKtide not only improved steatohepatitis, dyslipidemia, and insulin sensitivity but also ameliorated significant aortic atherosclerosis. Collectively, this study demonstrates that the Na/K-ATPase/ROS amplification loop contributes significantly to the development and progression of steatohepatitis and atherosclerosis. Furthermore, this study presents a potential treatment, the pNaKtide, for the metabolic syndrome phenotype.
C1 [Sodhi, Komal; Srikanthan, Krithika; Goguet-Rubio, Perrine; Nichols, Alexandra; Nawab, Athar; Shah, Preeya T.; Chaudhry, Muhammad; El-Hamdani, Mehiar; Xie, Zijian; Shapiro, Joseph I.] Marshall Univ, Joan C Edwards Sch Med, Dept Med Surg & Cardiol, Huntington, WV 25755 USA.
C3 Marshall University
RP Sodhi, K (corresponding author), Marshall Univ, Joan C Edwards Sch Med, Dept Med Surg & Cardiol, Huntington, WV 25755 USA.
EM sodhi@marshall.edu
FU National Institutes of Health [HL109015, HL071556, HL105649]; Brick
   street Foundation; Huntington Foundation, Inc.
FX Acknowledgements This work was supported by National Institutes of
   Health Grants HL109015 (to J.I.S. and Z.X.) , HL071556 and HL105649 (to
   J.I.S.) , by the Brick street Foundation (to J.I.S.) and by the
   Huntington Foundation, Inc.
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NR 45
TC 0
Z9 0
U1 1
U2 2
PU C M B  ASSOC
PI POITIERS
PA 34 BOULEVARD SOLFERINO, 86000 POITIERS, FRANCE
SN 0145-5680
EI 1165-158X
J9 CELL MOL BIOL
JI Cell. Mol. Biol.
PY 2023
VL 69
IS 2
BP 162
EP 171
DI 10.14715/cmb/2023.69.2.27
PG 10
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA J6IB5
UT WOS:001010619600027
PM 37224028
OA hybrid
DA 2025-06-11
ER

PT J
AU Zapata, RC
   Nasamran, CA
   Chilin-Fuentes, DR
   Dulawa, SC
   Osborn, O
AF Zapata, Rizaldy C. C.
   Nasamran, Chanond A. A.
   Chilin-Fuentes, Daisy R. R.
   Dulawa, Stephanie C. C.
   Osborn, Olivia
TI Identification of adipose tissue transcriptomic memory of anorexia
   nervosa
SO MOLECULAR MEDICINE
LA English
DT Article
DE Anorexia nervosa; Undernutrition; Transcriptomic memory; Adipose tissue;
   Calm2; Vps13d
ID EXPERIMENTAL WEIGHT PERTURBATION; MUSCLE WORK EFFICIENCY;
   SKELETAL-MUSCLE; INSULIN-RESISTANCE; METABOLIC SYNDROME; LEPTIN LEVELS;
   FOOD-INTAKE; OBESITY; ENERGY; GAIN
AB BackgroundAnorexia nervosa (AN) is a complex debilitating disease characterized by intense fear of weight gain and excessive exercise. It is the deadliest of any psychiatric disorder with a high rate of recidivism, yet its pathophysiology is unclear. The Activity-Based Anorexia (ABA) paradigm is a widely accepted mouse model of AN that recapitulates hypophagia and hyperactivity despite reduced body weight, however, not the chronicity.MethodsHere, we modified the prototypical ABA paradigm to increase the time to lose 25% of baseline body weight from less than 7 days to more than 2 weeks. We used this paradigm to identify persistently altered genes after weight restoration that represent a transcriptomic memory of under-nutrition and may contribute to AN relapse using RNA sequencing. We focused on adipose tissue as it was identified as a major location of transcriptomic memory of over-nutririon.ResultsWe identified 300 dysregulated genes that were refractory to weight restroration after ABA, including Calm2 and Vps13d, which could be potential global regulators of transcriptomic memory in both chronic over- and under-nutrition.ConclusionWe demonstrated the presence of peristent changes in the adipose tissue transcriptome in the ABA mice after weight restoration. Despite being on the opposite spectrum of weight perturbations, majority of the transcriptomic memory genes of under- and over-nutrition did not overlap, suggestive of the different mechanisms involved in these extreme nutritional statuses.
C1 [Zapata, Rizaldy C. C.; Osborn, Olivia] Univ Calif San Diego, Sch Med, Div Endocrinol & Metab, San Diego, CA 92093 USA.
   [Nasamran, Chanond A. A.; Chilin-Fuentes, Daisy R. R.] Univ Calif San Diego, Ctr Computat Biol & Bioinformat, Sch Med, San Diego, CA USA.
   [Dulawa, Stephanie C. C.] Univ Calif San Diego, Sch Med, Dept Psychiat, San Diego, CA 92093 USA.
C3 University of California System; University of California San Diego;
   University of California System; University of California San Diego;
   University of California System; University of California San Diego
RP Zapata, RC (corresponding author), Univ Calif San Diego, Sch Med, Div Endocrinol & Metab, San Diego, CA 92093 USA.
EM rczapata@health.ucsd.edu
RI osborn, olivia/R-1460-2018
OI Zapata, Rizaldy/0000-0003-4745-8513
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NR 71
TC 4
Z9 4
U1 0
U2 3
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1076-1551
EI 1528-3658
J9 MOL MED
JI Mol. Med.
PD AUG 15
PY 2023
VL 29
IS 1
AR 109
DI 10.1186/s10020-023-00705-7
PG 12
WC Biochemistry & Molecular Biology; Cell Biology; Medicine, Research &
   Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology; Research & Experimental
   Medicine
GA P1LR6
UT WOS:001048330300002
PM 37582711
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Oliva, ME
   Degrave, V
   Ingaramo, P
   Collins, P
   D'Alessandro, ME
AF Oliva, Maria Eugenia
   Degrave, Valentina
   Ingaramo, Paola
   Collins, Pablo
   D'Alessandro, Maria Eugenia
TI Effects of astaxanthin on the mechanisms involved in skeletal muscle
   lipid metabolism and oxidative stress in an experimental model of
   metabolic syndrome
SO FOOD & FUNCTION
LA English
DT Article; Early Access
ID INSULIN; LIPOGENESIS
AB This study aimed to evaluate the mechanisms involved in skeletal muscle lipotoxicity, impaired lipid metabolism, and oxidative stress induced by a sucrose-rich diet (SRD) that mimics human Metabolic Syndrome (MS), and to assess the preventive effects and molecular mechanisms of astaxanthin (AXT) extracted from freshwater crabs (Dilocarcinus pagei) on these alterations. Male Wistar rats received a reference diet (RD), RD + AXT, SRD, or SRD + AXT (10 mg kg-1 day-1 orally) for 90 days. Serum glucose, triglycerides, and cholesterol were measured. In skeletal muscle, triglyceride content, activities of lipogenic enzymes [fatty acid synthase (FAS), acetyl-CoA carboxylase (ACC), malic enzyme (ME), glucose-6-phosphate dehydrogenase (G-6-PDH)] and mitochondrial beta-oxidation enzyme [carnitine palmitoyltransferase-1 (CPT-1)] were assessed, along with the expression of transcription factors sterol regulatory element binding protein-1c (SREBP-1c) and peroxisome proliferator-activated receptor-alpha (PPAR alpha) by qPCR. Oxidative stress was evaluated by reactive oxygen species (ROS), glutathione (GSH), and antioxidant enzymes (CAT, GPx, GR), as well as pNF kappa B p65 and NrF2 protein levels. SRD feeding induced dyslipidemia, intramuscular triglyceride accumulation, increased de novo lipogenesis and SREBP-1c expression, and reduced CPT-1 activity and PPAR alpha expression in skeletal muscle. Oxidative stress was evidenced by elevated ROS and decreased GSH and antioxidant enzyme activities, with reduced NrF2 and increased pNF kappa B p65 levels. AXT supplementation attenuated these alterations by downregulating lipogenic enzymes and SREBP-1c, enhancing CPT-1 and PPAR alpha expression, and modulating NrF2 and pNF kappa B p65, thus improving lipid metabolism and redox balance in skeletal muscle. This study revealed new aspects of skeletal muscle lipid accumulation, lipid metabolism, and oxidative stress in SRD-fed rats. We demonstrated the novel properties and molecular mechanisms of AXT extracted from freshwater crabs on these parameters in the skeletal muscle of an experimental model of MS.
C1 [Oliva, Maria Eugenia; Degrave, Valentina; D'Alessandro, Maria Eugenia] Univ Nacl Litoral, Fac Bioquim & Ciencias Biol, Lab Estudio Enfermedades Metab Relacionadas Nutr, Ciudad Univ,cc242, RA-3000 Santa Fe, Argentina.
   [Oliva, Maria Eugenia; D'Alessandro, Maria Eugenia] Consejo Nacl Invest Cient & Tecn CONICET, Santa Fe, Argentina.
   [Ingaramo, Paola] Consejo Nacl Invest Cient & Tecn CONICET, Inst Salud & Ambiente Litoral ISAL, Fac Bioquim & Ciencias Biol, Santa Fe, Argentina.
   [Collins, Pablo] FBCB UNL, Catedra Limnol, COE INTA Angel Gallardo EEA, Rafaela, Argentina.
C3 National University of the Littoral; Consejo Nacional de Investigaciones
   Cientificas y Tecnicas (CONICET); Consejo Nacional de Investigaciones
   Cientificas y Tecnicas (CONICET)
RP D'Alessandro, ME (corresponding author), Univ Nacl Litoral, Fac Bioquim & Ciencias Biol, Lab Estudio Enfermedades Metab Relacionadas Nutr, Ciudad Univ,cc242, RA-3000 Santa Fe, Argentina.; D'Alessandro, ME (corresponding author), Consejo Nacl Invest Cient & Tecn CONICET, Santa Fe, Argentina.
EM medaless@fbcb.unl.edu.ar
RI Oliva, Maria/IUM-4089-2023
OI Oliva, Maria Eugenia/0000-0002-4368-4102
FU Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET),
   Argentina [PIP 2021-2023 GI 11220200101185CO]
FX This work was supported by Consejo Nacional de Investigaciones
   Cientificas y Tecnicas (CONICET), Argentina [PIP 2021-2023 GI
   #11220200101185CO]. The authors would like to thank Candelaria Mauti for
   their skillful technical assistance.
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NR 48
TC 0
Z9 0
U1 1
U2 1
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PD 2025 MAY 20
PY 2025
DI 10.1039/d5fo02156a
EA MAY 2025
PG 11
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA 2WW3U
UT WOS:001493237400001
PM 40407785
DA 2025-06-11
ER

PT J
AU Aiello, A
   Di Bona, D
   Candore, G
   Carru, C
   Zinellu, A
   Di Miceli, G
   Nicosia, A
   Gambino, CM
   Ruisi, P
   Caruso, C
   Vasto, S
   Accardi, G
AF Aiello, Anna
   Di Bona, Danilo
   Candore, Giuseppina
   Carru, Ciriaco
   Zinellu, Angelo
   Di Miceli, Giuseppe
   Nicosia, Aldo
   Gambino, Caterina Maria
   Ruisi, Paolo
   Caruso, Calogero
   Vasto, Sonya
   Accardi, Giulia
TI Targeting Aging with Functional Food: Pasta with Opuntia
   Single-Arm Pilot Study
SO REJUVENATION RESEARCH
LA English
DT Article
DE age-related diseases; Mediterranean diet; nutrition; Opuntia Ficus
   Indica; oxidative stress
ID FICUS-INDICA; URIC-ACID; METABOLIC SYNDROME; OXIDATIVE STRESS;
   RISK-FACTORS; BODY-WEIGHT; CACTUS; ANTIOXIDANT; CLADODES; BLOOD
AB Interventions to extend life span represent the new perspective in aging investigation. Healthy dietary habits are important modifiable factors that can favor a healthy aging phenotype. Many studies have demonstrated benefits for metabolic syndrome and type 2 diabetes mellitus resulting from the traditional Mediterranean foods. Opuntia Ficus Indica (OFI), widespread in the Mediterranean basin, belongs to the Cactaceae family. It is known for its antioxidant and anti-inflammatory properties. Moreover, products containing extracts from OFI fruits or cladodes have been used to control obesity and other metabolic parameters, such as glycemia and lipid profile. The aim of this study was to analyze the antioxidant and anti-inflammatory effect of pasta with 3% of OFI cladode extracts added to show its beneficial effect in human health. We performed a single arm longitudinal intervention study in 42 healthy volunteers, administrating 500g/week of this functional pasta for 30 days. Our pasta had antioxidant and anti-inflammatory properties with putative effect on the aging process and related metabolic diseases. We also demonstrated a hypoglycemic effect. The results are preliminary, but it is possible to speculate that our pasta could be considered an effective food for the prevention of age-related metabolic disorders.
C1 [Aiello, Anna; Candore, Giuseppina; Gambino, Caterina Maria; Caruso, Calogero; Accardi, Giulia] Univ Palermo, Dept Pathobiol & Med Biotechnol, Corso Tukory 211, I-90134 Palermo, Italy.
   [Di Bona, Danilo] Univ Bari Aldo Moro, Dept Emergency & Organ Transplants, Bari, Italy.
   [Carru, Ciriaco; Zinellu, Angelo] Univ Sassari, Dept Biomed Sci, Sassari, Italy.
   [Di Miceli, Giuseppe; Ruisi, Paolo] Univ Palermo, Dept Agr & Forest Sci, Palermo, Italy.
   [Nicosia, Aldo] CNR, Lab Mol Ecol & Biotechnol, Inst Marine & Coastal Environm IAMC CNR, Detached Unit Capo Granitola, Trapani, Italy.
   [Vasto, Sonya] Univ Palermo, Dept Biol Chem & Pharmaceut Sci & Technol, Palermo, Italy.
C3 University of Palermo; Universita degli Studi di Bari Aldo Moro;
   University of Sassari; University of Palermo; Consiglio Nazionale delle
   Ricerche (CNR); L'Istituto per l'Ambiente Marino Costiero (IAMC-CNR);
   University of Palermo
RP Caruso, C (corresponding author), Univ Palermo, Dept Pathobiol & Med Biotechnol, Corso Tukory 211, I-90134 Palermo, Italy.
EM calogero.caruso@unipa.it
RI GAMBINO, CATERINA/AAC-2871-2019; Carru, Ciriaco/AAI-9996-2021; accardi,
   giulia/K-3835-2018; Candore, Giuseppina/K-9496-2016; Di Miceli,
   Giuseppe/HZK-3174-2023; Nicosia, Aldo/R-4462-2017; Vasto,
   Sonya/I-4771-2013
OI Candore, Giuseppina/0000-0002-9966-934X; Accardi,
   Giulia/0000-0003-3565-9529; Nicosia, Aldo/0000-0002-1013-2862; Zinellu,
   Angelo/0000-0002-8396-0968; Vasto, Sonya/0000-0002-6033-4745; DI MICELI,
   Giuseppe/0000-0002-8076-5972; Carru, Ciriaco/0000-0002-6985-4907;
   Gambino, Caterina Maria/0000-0003-2937-3428
FU PON DI.ME.SA. (Programma Operativo Nazionale Ricerca e Competitivita)
   [PON02_00451_3361785]
FX The original work was supported by PON DI.ME.SA. (Programma Operativo
   Nazionale Ricerca e Competitivita) 2007/2013 - Progetto 'DI.ME.SA.'
   PON02_00451_3361785 (Valorization of Typical Products of the
   Mediterranean Diet and Their Nutraceutical Use to Improve Health) given
   to C.C. and G.C. The Institutional Ethics Committee (Policlinico Paolo
   Giaccone, University Hospital) approved the study protocol. The authors
   thank Antonella Plaia for her contribution to statistical analysis, and
   Marcello Tagliavia and Angela Cuttitta for their contribution to data
   collection.
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NR 62
TC 15
Z9 15
U1 0
U2 18
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1549-1684
EI 1557-8577
J9 REJUV RES
JI Rejuv. Res.
PD JUN
PY 2018
VL 21
IS 3
BP 249
EP 256
DI 10.1089/rej.2017.1992
PG 8
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA GJ4DA
UT WOS:000435329000007
PM 28851251
DA 2025-06-11
ER

PT J
AU Lim, S
   Oh, TJ
   Koh, KK
AF Lim, Soo
   Oh, Tae Jung
   Koh, Kwang Kon
TI Mechanistic link between nonalcoholic fatty liver disease and
   cardiometabolic disorders
SO INTERNATIONAL JOURNAL OF CARDIOLOGY
LA English
DT Review
DE Non-alcoholic fatty liver disease; Insulin resistance; Inflammation;
   Oxidative stress; Gut microbiota; Cardiovascular disease;
   Atherosclerosis
ID GLYCATION END-PRODUCTS; INTESTINAL BACTERIAL OVERGROWTH; HEPATIC
   INSULIN-RESISTANCE; GAMMA-GLUTAMYL-TRANSFERASE; ACTIVATED
   PROTEIN-KINASE; C-REACTIVE PROTEIN; TERM-FOLLOW-UP; METABOLIC SYNDROME;
   ALANINE AMINOTRANSFERASE; CARDIOVASCULAR-DISEASE
AB Nonalcoholic fatty liver disease (NAFLD) is a chronic condition characterized by fat accumulation combined with low-grade inflammation in the liver. A large body of clinical and experimental data shows that increased flux of free fatty acids from increased visceral adipose tissue can lead to NAFLD related with insulin resistance. Thus, individuals with obesity, insulin resistance, and dyslipidemia are at the greatest risk of developing NAFLD. Conversely, NAFLD is one of the phenotypes of insulin resistance or metabolic syndrome. Many researchers have discovered a close association between NAFLD and insulin resistance, and focused on the role of NAFLD in the development of type 2 diabetes. Further, substantial evidence has suggested the association between NAFLD and cardiovascular disease (CVD). In the current review, we provide a plausible mechanistic link between NAFLD and CVD and the potential of the former as a therapeutic target based on pathophysiology. We also discuss in detail about the role of insulin resistance, oxidative stress, low-grade inflammation, abnormal lipid metabolism, gut microbiota, changes of biomarkers, and genetic predisposition in the pathological linking between NAFLD and cardiometabolic disorders. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
C1 [Lim, Soo; Oh, Tae Jung] Seoul Natl Univ, Coll Med, Dept Internal Med, Songnam 463070, South Korea.
   [Lim, Soo; Oh, Tae Jung] Seoul Natl Univ, Bundang Hosp, Songnam 463070, South Korea.
   [Koh, Kwang Kon] Gachon Univ, Gil Med Ctr, Dept Cardiol, Inchon, South Korea.
   [Koh, Kwang Kon] Gachon Cardiovasc Res Inst, Inchon, South Korea.
C3 Seoul National University (SNU); Seoul National University (SNU); Gachon
   University; Gachon University
RP Lim, S (corresponding author), Seoul Natl Univ, Coll Med, Dept Internal Med, 300 Gumi Dong, Songnam 463070, South Korea.
EM limsoo@snu.ac.kr; kwangk@gilhospital.com
RI Lim, Soo/AAU-8107-2020; Oh, Tae Jung/K-8863-2018
OI Lim, Soo/0000-0002-4137-1671; Oh, Tae Jung/0000-0002-5078-6123
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NR 101
TC 56
Z9 60
U1 0
U2 50
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0167-5273
EI 1874-1754
J9 INT J CARDIOL
JI Int. J. Cardiol.
PD DEC 15
PY 2015
VL 201
BP 408
EP 414
DI 10.1016/j.ijcard.2015.08.107
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA CY1CL
UT WOS:000366144200120
PM 26310987
DA 2025-06-11
ER

PT J
AU Nascimento-Carvalho, B
   Dos-Santos, A
   Da Costa-Santos, N
   Carvalho, SL
   de Moraes, OA
   Santos, CP
   De Angelis, K
   Caperuto, EC
   Irigoyen, MC
   Scapini, KB
   Sanches, IC
AF Nascimento-Carvalho, Bruno
   Dos-Santos, Adriano
   Da Costa-Santos, Nicolas
   Carvalho, Sabrina L.
   de Moraes, Oscar A.
   Santos, Camila P.
   De Angelis, Katia
   Caperuto, Erico C.
   Irigoyen, Maria-Claudia
   Scapini, Katia B.
   Sanches, Iris C.
TI Food readjustment plus exercise training improves cardiovascular
   autonomic control and baroreflex sensitivity in high-fat diet-fed
   ovariectomized mice
SO PHYSIOLOGICAL REPORTS
LA English
DT Article
DE autonomic nervous system; food adjustment; inflammation; menopause;
   physical training
ID OXIDATIVE STRESS; BLOOD-PRESSURE; HEART-RATE; ESTROGEN; MODEL;
   ASSOCIATION; VARIABILITY; RESISTANCE; IMPACT
AB Despite consensus on the benefits of food readjustment and/or moderate-intensity continuous exercise in the treatment of cardiometabolic risk factors, there is little evidence of the association between these two cardiovascular risk management strategies after menopause. Thus, the objective of this study was to evaluate the effects of food readjustment and/or exercise training on metabolic, hemodynamic, autonomic, and inflammatory parameters in a model of loss of ovarian function with diet-induced obesity. Forty C57BL/6J ovariectomized mice were divided into the following groups: high-fat diet-fed - 60% lipids throughout the protocol (HF), food readjustment - 60% lipids for 5 weeks, readjusted to 10% for the next 5 weeks (FR), high-fat diet-fed undergoing moderate-intensity exercise training (HFT), and food readjustment associated with moderate-intensity exercise training (FRT). Blood glucose evaluations and oral glucose tolerance tests were performed. Blood pressure was assessed by direct intra-arterial measurement. Baroreflex sensitivity was tested using heart rate phenylephrine and sodium nitroprusside induced blood pressure changes. Cardiovascular autonomic modulation was evaluated in time and frequency domains. Inflammatory profile was evaluated by IL-6, IL-10 cytokines, and TNF-alpha measurements. Only the exercise training associated with food readjustment strategy induced improved functional capacity, body composition, metabolic parameters, inflammatory profile, and resting bradycardia, while positively changing cardiovascular autonomic modulation and increasing baroreflex sensitivity. Our findings demonstrate that the association of these strategies seems to be effective in the management of cardiometabolic risk in a model of loss of ovarian function with diet-induced obesity.
C1 [Nascimento-Carvalho, Bruno; de Moraes, Oscar A.; Irigoyen, Maria-Claudia] Univ Sao Paulo InCor HCFMUSP, Hosp Clin, Fac Med, Unidade Hipertensao, Sao Paulo, Brazil.
   [Nascimento-Carvalho, Bruno; Dos-Santos, Adriano; Da Costa-Santos, Nicolas; Carvalho, Sabrina L.; Caperuto, Erico C.; Scapini, Katia B.] Sao Judas Tadeu Univ USJT, Human Movement Lab, Sao Paulo, Brazil.
   [Santos, Camila P.; De Angelis, Katia] Fed Univ Sao Paulo Unifesp, Dept Med, Sao Paulo, Brazil.
   [Irigoyen, Maria-Claudia] Univ Sao Paulo InCor HCFMUSP, Hosp Clin, Fac Med, Unidade Hipertensao,Inst Coracao, Ave Dr Eneas Carvalho de Aguiar 44, BR-05403900 Sao Paulo, SP, Brazil.
C3 Universidade de Sao Paulo; Universidade Sao Judas Tadeu; Universidade
   Federal de Sao Paulo (UNIFESP)
RP Irigoyen, MC (corresponding author), Univ Sao Paulo InCor HCFMUSP, Hosp Clin, Fac Med, Unidade Hipertensao,Inst Coracao, Ave Dr Eneas Carvalho de Aguiar 44, BR-05403900 Sao Paulo, SP, Brazil.
EM hipirigoyen@gmail.com
RI IRIGOYEN, MARIA/N-6880-2014; Nascimento-Carvalho, Bruno/HLX-3548-2023;
   Caperuto, Erico/I-3605-2014; DE ANGELIS, KATIA/I-6098-2016; Santos,
   Adriano/ABH-6885-2020; Sanches, Iris Callado/D-5079-2013
OI Sanches, Iris Callado/0000-0001-6195-4340; do Nascimento Carvalho,
   Bruno/0000-0002-0283-7432
FU Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior- Brazil
   (CAPES) [001?]; Conselho Nacional de Desenvolvimento Cientifico e
   Tecnologico (PQ -CNPq) [307138/2015-1, 435123/2018-1]; ANIMA
   INSTITUTE-AI
FX This study was financed in part by the Coordenacao de Aperfeicoamento de
   Pessoal de Nivel Superior- Brazil (CAPES)- Finance Code 001?; Conselho
   Nacional de Desenvolvimento Cientifico e Tecnologico (PQ -CNPq -process
   307138/2015-1 and process 435123/2018-1); and ANIMA INSTITUTE-AI. CAPES
   provided support for personal demands of the main author; CNPq provided
   support for laboratory demands of research. ANIMA provided support for
   Human Movement Lab, Sao Judas University.
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NR 35
TC 2
Z9 2
U1 0
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2051-817X
J9 PHYSIOL REP
JI PHYSIOL. REP.
PD MAR
PY 2023
VL 11
IS 5
AR e15609
DI 10.14814/phy2.15609
PG 10
WC Physiology
WE Emerging Sources Citation Index (ESCI)
SC Physiology
GA 9S8LO
UT WOS:000946588200001
PM 36898722
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Gong, ZT
   Zhang, LS
   Shi, YL
AF Gong, Zhentao
   Zhang, Lingshan
   Shi, Yingli
TI The potential role of uric acid in women with polycystic ovary syndrome
SO GYNECOLOGICAL ENDOCRINOLOGY
LA English
DT Review
DE Polycystic ovary syndrome; uric acid; hyperandrogenism; metabolic
   syndrome; oxidative stress; insulin resistance
ID HORMONE REPLACEMENT THERAPY; INSULIN-RESISTANCE; RISK-FACTORS; METABOLIC
   SYNDROME; OXIDATIVE STRESS; SERUM URATE; BARIATRIC SURGERY;
   BLOOD-PRESSURE; WEIGHT-LOSS; ANTIOXIDANT DEFENSE
AB Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder among women of reproductive age and is associated with a variety of multi-system complications. The prevailing treatment strategy for PCOS is to individualize the interventions based on individual symptoms and patient complaints. However, optimal efficacy in treatment necessitates a focus on addressing the underlying pathogenic mechanisms. Uric acid (UA), the end product of purine metabolism, has been suggested to be involved in the development of several diseases, including PCOS. However, the precise mechanisms by which UA may affect PCOS remain incompletely understood. This literature review aims to investigate the correlation between UA and the various clinical presentations of PCOS, such as hyperandrogenism, insulin resistance (IR), ovulation disorders, obesity, and other related manifestations, through the analysis of epidemiological and clinical studies. The purpose of this study is to improve our comprehension of how UA contributes to each aspect of PCOS and their interrelationship, thus identifying the potential role of UA as a facilitator of PCOS. Furthermore, we explore potential pathways linking UA and PCOS, and propose therapeutic interventions based on these findings to optimize the management of this condition.
C1 [Gong, Zhentao; Zhang, Lingshan; Shi, Yingli] Fudan Univ, Obstet & Gynecol Hosp, Shanghai, Peoples R China.
   [Gong, Zhentao; Shi, Yingli] Fudan Univ, Shanghai Med Coll, Shanghai, Peoples R China.
   [Shi, Yingli] Shanghai Key Lab Female Reprod Endocrine Related D, Shanghai, Peoples R China.
   [Shi, Yingli] 128 Shenyang Rd, Shanghai, Peoples R China.
C3 Fudan University; Fudan University
RP Shi, YL (corresponding author), 128 Shenyang Rd, Shanghai, Peoples R China.
EM shiyingli@fudan.edu.cn
RI Gong, Zhentao/KDO-2143-2024
OI Gong, Zhentao/0000-0002-1664-3612; Shi, Yingli/0000-0002-7595-6678
FU Natural Science Foundation of Shanghai [19ZR1406700]
FX This research was sponsored by Natural Science Foundation of Shanghai
   [No. 19ZR1406700 to Yingli Shi].
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NR 142
TC 1
Z9 1
U1 5
U2 14
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0951-3590
EI 1473-0766
J9 GYNECOL ENDOCRINOL
JI Gynecol. Endocrinol.
PD DEC 31
PY 2024
VL 40
IS 1
AR 2323725
DI 10.1080/09513590.2024.2323725
PG 10
WC Endocrinology & Metabolism; Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Obstetrics & Gynecology
GA KD7W8
UT WOS:001178096700001
PM 39718393
OA gold
DA 2025-06-11
ER

PT J
AU Hata, J
   Harigane, Y
   Matsuoka, K
   Akaihata, H
   Yaginuma, K
   Meguro, S
   Hoshi, S
   Sato, Y
   Ogawa, S
   Uemura, M
   Kojima, Y
AF Hata, Junya
   Harigane, Yuki
   Matsuoka, Kanako
   Akaihata, Hidenori
   Yaginuma, Kei
   Meguro, Satoru
   Hoshi, Seiji
   Sato, Yuichi
   Ogawa, Soichiro
   Uemura, Motohide
   Kojima, Yoshiyuki
TI Mechanism of Androgen-Independent Stromal Proliferation in Benign
   Prostatic Hyperplasia
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE benign prostatic hyperplasia; stromal proliferation; androgen
   independent; autoimmune reaction
ID OXIDATIVE STRESS; REACTIVE STROMA; GROWTH-FACTOR; EPITHELIAL
   INTERACTIONS; TRICHOMONAS-VAGINALIS; METABOLIC SYNDROME; STEM-CELLS;
   T-CELLS; INFLAMMATION; PROGRESSION
AB Benign prostatic hyperplasia (BPH) is a chronic proliferative disease showing stromal-dominant proliferation. However, the detailed proliferation mechanism has remained unclear. Although aging and androgen have been reported as definitive risk factors for BPH, recent studies have focused on the involvement of androgen-independent factors. Androgen-independent factors include ischemia, oxidative stress, metabolic syndrome, infection, autoimmune reactions, and inflammation, with inflammation in BPH tissues playing a central role in the BPH proliferative process. Inflammation in BPH tissues by various factors finally leads to tissue remodeling and stromal proliferation through the wound healing process of the prostate. To elucidate the proliferative mechanism of BPH, a study using whole-genome gene expression analysis in a stromal-dominant BPH rat model was performed and showed that immune response-related pathways and complement classical pathways are activated. Furthermore, expression analysis using this BPH rat model showed that the autoimmune reaction triggered complement pathway activation in the proliferative process of BPH. BPH is a multifactorial disease, and understanding the role of androgen-independent factors including immune responses contributes to elucidating the pathogenesis of BPH. Androgen-independent factors may lead to new therapeutic targets for BPH, and further development of this research is expected.
C1 [Hata, Junya; Harigane, Yuki; Matsuoka, Kanako; Akaihata, Hidenori; Yaginuma, Kei; Meguro, Satoru; Hoshi, Seiji; Sato, Yuichi; Ogawa, Soichiro; Uemura, Motohide; Kojima, Yoshiyuki] Fukushima Med Univ, Dept Urol, Sch Med, 1 Hikarigaoka, Fukushima 9601295, Japan.
C3 Fukushima Medical University
RP Hata, J (corresponding author), Fukushima Med Univ, Dept Urol, Sch Med, 1 Hikarigaoka, Fukushima 9601295, Japan.
EM akju826@fmu.ac.jp; uroharry@fmu.ac.jp; kanaco@fmu.ac.jp;
   hakai@fmu.ac.jp; uro-yagi@fmu.ac.jp; s-meguro@fmu.ac.jp;
   uro-hoshi@fmu.ac.jp; ysato@fmu.ac.jp; soh@fmu.ac.jp; muemura@fmu.ac.jp;
   ykojima@fmu.ac.jp
RI hoshi, seiji/L-7385-2017
OI Matsuoka, Kanako/0000-0002-0731-4577; Yaginuma, Kei/0009-0004-1616-3266;
   Harigane, Yuki/0009-0001-8696-9853; Meguro, Satoru/0000-0003-2179-5028;
   Hata, Junya/0000-0002-7912-5468
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NR 118
TC 16
Z9 17
U1 0
U2 17
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD JUL
PY 2023
VL 24
IS 14
AR 11634
DI 10.3390/ijms241411634
PG 15
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA N3GW5
UT WOS:001035948300001
PM 37511400
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Derrick, SA
   Kristo, AS
   Reaves, SK
   Sikalidis, AK
AF Derrick, Stefani A.
   Kristo, Aleksandra S.
   Reaves, Scott K.
   Sikalidis, Angelos K.
TI Effects of Dietary Red Raspberry Consumption on Pre-Diabetes and Type 2
   Diabetes Mellitus Parameters
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Review
DE red raspberries; western diet; type 2 diabetes mellitus; pre-diabetes;
   metabolic syndrome
ID GUT MICROBIOTA; HEALTH; STRESS; BIOMARKERS; BERRIES; KETONE; LIVER;
   FRUIT; RISK
AB Type 2 diabetes mellitus (T2DM) is a chronic metabolic condition characterized by glucose clearance abnormalities and insufficient insulin response. Left uncontrolled, T2DM can result in serious complications and death. With no cure available currently and the prevalence of major risk factors such as pre-diabetes and the metabolic syndrome continuously increasing, there is an urgent need for effective treatments with limited or no side effects. Red raspberries (RR) contain various phytonutrients with potential for modulating insulin function, glucose, and lipid metabolism. The objective of this literature review was to investigate the potential metabolic benefits of dietary RR in individuals with T2DM and pre-diabetes. A search of major scientific databases was employed to identify peer-reviewed, in vivo, or human studies that utilized whole RR or its functional constituents as treatment. The studies examined provide evidence that RR may offer clinically beneficial effects for the prevention and management of chronic diseases through improvements in glucose handling and insulin sensitivity, adiposity, lipid profiles, ectopic lipid accumulation, inflammation, oxidative stress, and cardiac health. More human trials and in vivo studies are needed to confirm the benefits of dietary RR in T2DM and pre-diabetes and to explore the dose-dependent relationships, optimal duration, and treatment modality.
C1 [Derrick, Stefani A.; Kristo, Aleksandra S.; Reaves, Scott K.; Sikalidis, Angelos K.] Calif Polytech State Univ San Luis Obispo, Dept Food Sci & Nutr, 1 Grand Ave, San Luis Obispo, CA 93407 USA.
C3 California State University System; California Polytechnic State
   University San Luis Obispo
RP Sikalidis, AK (corresponding author), Calif Polytech State Univ San Luis Obispo, Dept Food Sci & Nutr, 1 Grand Ave, San Luis Obispo, CA 93407 USA.
EM sderrick@calpoly.edu; akristo@calpoly.edu; sreaves@calpoly.edu;
   asikalid@calpoly.edu
RI Kristo, Aleksandra/AHC-3770-2022; Sikalidis, Angelos/L-4690-2019
OI Kristo, Aleksandra S./0000-0002-0733-4041; Derrick,
   Stefani/0000-0001-5792-8385; Sikalidis, Angelos/0000-0003-3487-4120
FU California State University Agriculture Research Institute (ARI)
   [20-03-120]
FX Partial funding for this project has been made available by the
   California State University Agriculture Research Institute (ARI).
   Funding was through ARI seed grant #20-03-120, awarded to Angelos K.
   Sikalidis.
CR American Diabetes Association (ADA), BURD DIAB CAL
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NR 60
TC 23
Z9 25
U1 3
U2 43
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD SEP
PY 2021
VL 18
IS 17
AR 9364
DI 10.3390/ijerph18179364
PG 20
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA UN5LL
UT WOS:000694057900001
PM 34501954
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Lucchetti, BFC
   Boaretto, N
   Lopes, FNC
   Malvezi, AD
   Lovo-Martins, MI
   Tatakihara, VLH
   Fattori, V
   Pereira, RS
   Verri, WA
   Araujo, EJD
   Pinge, P
   Martins-Pinge, MC
AF Cruz Lucchetti, Bruno Fernando
   Boaretto, Natalia
   Cortegoso Lopes, Fernanda Novi
   Malvezi, Aparecida Donizette
   Lovo-Martins, Maria Isabel
   Hideko Tatakihara, Vera Lucia
   Fattori, Victor
   Pereira, Rito Santo
   Verri, Waldiceu Aparecido, Jr.
   de Almeida Araujo, Eduardo Jose
   Pinge-Filho, Phileno
   Martins-Pinge, Marli Cardoso
TI Metabolic syndrome agravates cardiovascular, oxidative and inflammatory
   dysfunction during the acute phase of Trypanosoma cruzi infection
   in mice
SO SCIENTIFIC REPORTS
LA English
DT Article
ID ADIPOSE-TISSUE; CHAGAS-DISEASE; NITRIC-OXIDE; INSULIN-RESISTANCE;
   INTRAVENOUS GLUCOSE; CYTOKINE PRODUCTION; BLOOD-GLUCOSE; OBESITY;
   STRESS; EXPRESSION
AB We evaluated the influence of metabolic syndrome (MS) on acute Trypanosoma cruzi infection. Obese Swiss mice, 70 days of age, were subjected to intraperitoneal infection with 5 x 10(2) trypomastigotes of the Y strain. Cardiovascular, oxidative, inflammatory, and metabolic parameters were evaluated in infected and non-infected mice. We observed higher parasitaemia in the infected obese group (IOG) than in the infected control group (ICG) 13 and 15 days post-infection. All IOG animals died by 19 days post-infection (dpi), whereas 87.5% of the ICG survived to 30 days. Increased plasma nitrite levels in adipose tissue and the aorta were observed in the IOG. Higher INF-(gamma) and MCP-1 concentrations and lower IL-10 concentrations were observed in the IOG compared to those in the ICG. Decreased insulin sensitivity was observed in obese animals, which was accentuated after infection. Higher parasitic loads were found in adipose and hepatic tissue, and increases in oxidative stress in cardiac, hepatic, and adipose tissues were characteristics of the IOG group. Thus, MS exacerbates experimental Chagas disease, resulting in greater damage and decreased survival in infected animals, and might be a warning sign that MS can influence other pathologies.
C1 [Cruz Lucchetti, Bruno Fernando; Boaretto, Natalia; Cortegoso Lopes, Fernanda Novi; Martins-Pinge, Marli Cardoso] Univ Estadual Londrina, Ctr Biol Sci, Dept Physiol Sci, Londrina, PR, Brazil.
   [Malvezi, Aparecida Donizette; Lovo-Martins, Maria Isabel; Hideko Tatakihara, Vera Lucia; Fattori, Victor; Pereira, Rito Santo; Verri, Waldiceu Aparecido, Jr.; Pinge-Filho, Phileno] Univ Estadual Londrina, Ctr Biol Sci, Dept Pathol Sci, Londrina, PR, Brazil.
   [de Almeida Araujo, Eduardo Jose] Univ Estadual Londrina, Ctr Biol Sci, Dept Histol, Londrina, PR, Brazil.
   [Cruz Lucchetti, Bruno Fernando] Univ Ctr Araguaia Valley, Dept Physiotherapy, Barra Do Garcas, MT, Brazil.
C3 Universidade Estadual de Londrina; Universidade Estadual de Londrina;
   Universidade Estadual de Londrina
RP Martins-Pinge, MC (corresponding author), Univ Estadual Londrina, Ctr Biol Sci, Dept Physiol Sci, Londrina, PR, Brazil.
EM martinspinge@uel.br
RI Pinge-Filho, Phileno/G-2844-2012; Fattori, Victor/C-2745-2016; Pereira,
   Rito/KIC-7669-2024; Verri, Waldiceu/I-1330-2013; de Almeida Araujo,
   Eduardo Jose/D-2397-2010; Martins-Pinge, Marli Cardoso/C-4417-2014
OI Pereira, Rito/0000-0002-3963-2019; Verri, Waldiceu/0000-0003-2756-9283;
   Boaretto, Natalia/0000-0003-2472-0582; de Almeida Araujo, Eduardo
   Jose/0000-0002-8609-5041; Martins-Pinge, Marli
   Cardoso/0000-0002-9444-1530
FU CAPES (Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior);
   CNPq (Conselho Nacional de Desenvolvimento Cientifico e Tecnologico)
FX This study was supported by CAPES (Coordenacao de Aperfeicoamento de
   Pessoal de Nivel Superior), for B.F.C.L., F.N.C.L. fellowship; CNPq
   (Conselho Nacional de Desenvolvimento Cientifico e Tecnologico) for the
   research fellows for W.A.V.J., P.P.F. and M.C.M.P. This research did not
   receive any specific grant from funding agencies in the public,
   commercial, or not-for-profit sectors.
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NR 95
TC 16
Z9 17
U1 0
U2 1
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD DEC 11
PY 2019
VL 9
AR 18885
DI 10.1038/s41598-019-55363-9
PG 16
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA JV8TB
UT WOS:000502632400001
PM 31827186
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Yen, CH
   Yang, NC
   Lee, BJ
   Lin, JY
   Hsia, S
   Lin, PT
AF Yen, Chi-Hua
   Yang, Nae-Cherng
   Lee, Bor-Jen
   Lin, Jui-Yuan
   Hsia, Simon
   Lin, Ping-Ting
TI The Antioxidant Status and Concentrations of Coenzyme Q10 and Vitamin E
   in Metabolic Syndrome
SO SCIENTIFIC WORLD JOURNAL
LA English
DT Article
ID 3RD NATIONAL-HEALTH; OXIDATIVE STRESS; DIABETES-MELLITUS; NUTRITION;
   SUPPLEMENTATION; HYPERTENSION; ASSOCIATION; POPULATION; PREVALENCE;
   PLASMA
AB The purpose of this study was to investigate the levels of coenzyme Q10 and vitamin E and the antioxidant status in subjects with metabolic syndrome (MS). Subjects with MS (n = 72) were included according to the criteria for MS. The non-MS group (n = 105) was comprised of healthy individuals with normal blood biochemical values. The plasma coenzyme Q10, vitamin E concentrations, lipid profiles, and antioxidant enzymes levels (catalase, superoxide dismutase, and glutathione peroxidase) were measured. The subjects with MS had significantly higher concentrations of plasma coenzyme Q10 and vitamin E than those in the non-MS group, but these differences were not significant after being normalized for triglyceride level. The levels of antioxidant enzymes were significantly lower in the MS group than in the non-MS group. The subjects with the higher antioxidant enzymes activities had significant reductions in the risk of MS (P < 0.01) after being adjusted for coenzyme Q10 and vitamin E. In conclusion, the subjects with MS might be under higher oxidative stress resulting in low levels of antioxidant enzyme activities. A higher level of antioxidant enzymes activities was significantly associated with a reduction in the risk of MS independent of the levels of coenzyme Q10 and vitamin E.
C1 [Yen, Chi-Hua] Chung Shan Med Univ Hosp, Dept Family & Community Med, Taichung 40201, Taiwan.
   [Yen, Chi-Hua] Chung Shan Med Univ, Sch Med, Taichung 40201, Taiwan.
   [Yen, Chi-Hua] Chung Shan Med Univ, Ctr Educ & Res Geriatr & Gerontol, Taichung 40201, Taiwan.
   [Yang, Nae-Cherng; Lin, Jui-Yuan; Lin, Ping-Ting] Chung Shan Med Univ, Sch Nutr, Taichung 40201, Taiwan.
   [Yang, Nae-Cherng; Lin, Ping-Ting] Chung Shan Med Univ Hosp, Dept Nutr, Taichung 40201, Taiwan.
   [Lee, Bor-Jen] Taichung Vet Gen Hosp, Intens Care Unit, Taichung 40705, Taiwan.
   [Hsia, Simon] Hungkuang Univ, Dept Nutr, Taichung 43346, Taiwan.
   [Hsia, Simon] Hungkuang Univ, Inst Biomed Nutr, Taichung 43346, Taiwan.
C3 Chung Shan Medical University; Chung Shan Medical University Hospital;
   Chung Shan Medical University; Chung Shan Medical University; Chung Shan
   Medical University; Chung Shan Medical University; Chung Shan Medical
   University Hospital; Taichung Veterans General Hospital; Hungkuang
   University; Hungkuang University
RP Lin, PT (corresponding author), Chung Shan Med Univ, Sch Nutr, Taichung 40201, Taiwan.
EM apt810@csmu.edu.tw
RI Yang, Nae-Cherng/ADE-3580-2022; Stefanadis, Christodoulos/ABH-2232-2020
OI Stefanadis, Christodoulos/0000-0001-5974-6454
FU National Science Council, Taiwan [NSC 99-2320-B-040-011]
FX This study was supported by a grant from the National Science Council
   (NSC 99-2320-B-040-011), Taiwan. The authors would like to express their
   sincere appreciation to the subjects for their participation. They thank
   the nurses at the Chung Shan Medical University Hospital for providing
   expert assistance in blood sample collection and data analysis.
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NR 33
TC 9
Z9 10
U1 0
U2 6
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1537-744X
J9 SCI WORLD J
JI Sci. World J.
PY 2013
AR 767968
DI 10.1155/2013/767968
PG 7
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 218GL
UT WOS:000324420700001
PM 24082857
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Cannizzo, B
   Luján, A
   Estrella, N
   Lembo, C
   Cruzado, M
   Castro, C
AF Cannizzo, Beatriz
   Lujan, Agustin
   Estrella, Natalia
   Lembo, Carina
   Cruzado, Montserrat
   Castro, Claudia
TI Insulin Resistance Promotes Early Atherosclerosis via Increased
   Proinflammatory Proteins and Oxidative Stress in Fructose-Fed ApoE-KO
   Mice
SO EXPERIMENTAL DIABETES RESEARCH
LA English
DT Article
ID RENIN-ANGIOTENSIN SYSTEM; MATRIX METALLOPROTEINASES;
   CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; NADPH OXIDASE; INFLAMMATION;
   ACTIVATION; EXPRESSION; VCAM-1; MODEL
AB High fructose intake induces an insulin resistance state associated with metabolic syndrome (MS). The effect of vascular inflammation in this model is not completely addressed. The aim of this study was to evaluate vascular remodeling, inflammatory and oxidative stress markers, and atheroma development in high-fructose diet-induced insulin resistance of ApoE-deficient mice (ApoE-KO). Mice were fed with either a normal chow or a 10% w/v fructose (HF) in drinking water over a period of 8 weeks. Thereafter, plasma metabolic parameters, vascular remodeling, atheroma lesion size, inflammatory markers, and NAD(P) H oxidase activity in the arteries were determined. HF diet induced a marked increase in plasma glucose, insulin, and triglycerides in ApoE-KO mice, provoked vascular remodeling, enhanced expression of vascular cell-adhesion molecule-1 (VCAM-1) and matrix metalloprotease 9 (MMP-9) and enlarged atherosclerotic lesion in aortic and carotid arteries. NAD(P) H oxidase activity was enhanced by fructose intake, and this effect was attenuated by tempol, a superoxide dismutase mimetic, and losartan, an Angiotensin II receptor antagonist. Our study results show that high-fructose-induced insulin resistance promotes a proinflammatory and prooxidant state which accelerates atherosclerotic plaque formation in ApoE-KO mice.
C1 [Cannizzo, Beatriz; Lujan, Agustin; Estrella, Natalia; Cruzado, Montserrat; Castro, Claudia] Univ Nacl Cuyo, Lab Vasc Biol, Fac Med Sci, Inst Med & Expt Biol Cuyo IMBECU CONICET, RA-5500 Mendoza, Argentina.
   [Lembo, Carina] Univ Nacl Cuyo, Lab Cardiovasc Pathophysiol, Fac Med Sci, Inst Med & Expt Biol Cuyo IMBECU CONICET, RA-5500 Mendoza, Argentina.
C3 University Nacional Cuyo Mendoza; Consejo Nacional de Investigaciones
   Cientificas y Tecnicas (CONICET); Consejo Nacional de Investigaciones
   Cientificas y Tecnicas (CONICET); University Nacional Cuyo Mendoza
RP Castro, C (corresponding author), Univ Nacl Cuyo, Lab Vasc Biol, Fac Med Sci, Inst Med & Expt Biol Cuyo IMBECU CONICET, RA-5500 Mendoza, Argentina.
EM ccastro@fcm.uncu.edu.ar
RI Lujan, Agustín Leonardo/KII-7379-2024
OI Castro, Claudia/0000-0002-8428-2484; Lujan, Agustin
   Leonardo/0000-0003-4906-6951
FU Secretaria de Ciencia y Tecnica, Universidad Nacional de Cuyo [06/J246];
   CONICET; National Agency of Scientific and Technological Promotion
FX This work was supported by Grant 06/J246 (to M. Cruzado), 2007-2009 from
   Secretaria de Ciencia y Tecnica, Universidad Nacional de Cuyo. B.
   cannizzo is a recipient of a doctoral fellowship from CONICET, and C.
   Lembo is a recipient of a doctoral fellowship from National Agency of
   Scientific and Technological Promotion. The authors gratefully
   acknowledge the technical assistance of Mrs. Miriam Garcia and Miss.
   Analia Redondo.
CR Berg G, 2011, CLIN CHIM ACTA, V412, P1731, DOI 10.1016/j.cca.2011.06.013
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NR 26
TC 24
Z9 30
U1 0
U2 17
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1687-5214
EI 1687-5303
J9 EXP DIABETES RES
JI Exp. Diabetes Res.
PY 2012
AR 941304
DI 10.1155/2012/941304
PG 8
WC Endocrinology & Metabolism; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Research & Experimental Medicine
GA 924GQ
UT WOS:000302680200001
PM 22474431
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Krone, RE
   Ewer, AK
   Barrett, TG
   Moy, RJ
   Bakour, S
   Maher, ER
   Thangaratinam, S
   Cox, P
   Martin, B
   Khan, KS
   Zeegers, MP
AF Krone, Ruth E.
   Ewer, Andrew K.
   Barrett, Timothy G.
   Moy, Robert J.
   Bakour, Shagaf
   Maher, Eamonn R.
   Thangaratinam, Shakila
   Cox, Philip
   Martin, Bill
   Khan, Khalid S.
   Zeegers, Maurice P.
TI The Birmingham Registry for Twin and Heritability Studies (BiRTHS)
SO TWIN RESEARCH AND HUMAN GENETICS
LA English
DT Article
ID CORONARY-ARTERY-DISEASE; POSTNATAL DEPRESSION; INSULIN-RESISTANCE;
   DIABETES-MELLITUS; POSTPARTUM DEPRESSION; CARDIOVASCULAR RISK; METABOLIC
   SYNDROME; MATERNAL OBESITY; PREVALENCE; WEIGHT
AB In this article we present the protocol of the Birmingham Registry for Twin Heritability Studies (BiRTHS), which aims to establish a long-term prospective twin registry with twins identified from the antenatal period and subjected to detailed follow-up. We plan to investigate the concordance in anthropometrics and early childhood phenotypes between 66 monozygotic and 154 dizygotic twin pairs in the first 2 years of recruitment. In this project we plan to determine the relative contributions of heritability and environment to fetal growth, birth size, growth in infancy and development up to 2 years of age in an ethnically mixed population. Twins will be assessed with the Griffitth's Mental Development Scales, which will enable us to obtain detailed information on development. As maternal depression may have an effect on the twins' neurodevelopment, the Edinburgh Postnatal Depression Scale will be used at various stages during pregnancy and after delivery to assess maternal depressive symptoms. The increasing prevalence of obesity in both adults and children has raised concerns about the effect of maternal obesity in pregnancy on fetal growth. The prospective study design gives us the opportunity to obtain data on maternal nutrition (reflected by body mass index) and ante- and postnatal growth and development of twins.
C1 Univ Birmingham, Dept Epidemiol & Publ Hlth, Unit Genet Epidemiol, Birmingham B15 2TT, W Midlands, England.
   Birmingham Womens Hosp, Neonatal Unit, Birmingham, W Midlands, England.
   Univ Birmingham, Inst Child Hlth, Birmingham B15 2TT, W Midlands, England.
   City Hosp, Dept Obstet & Gynaecol, Birmingham, W Midlands, England.
   Univ Birmingham, Sch Med, Dept Paediat & Child Hlth, Sect Med & Mol Genet, Birmingham, W Midlands, England.
   Birmingham Womens Hosp, Dept Obstet, Birmingham, W Midlands, England.
   Univ Birmingham, Dept Obstet & Gynecol, Birmingham, W Midlands, England.
C3 University of Birmingham; Birmingham Women's Hospital; University of
   Birmingham; University of Birmingham; University of Birmingham;
   Birmingham Women's Hospital; University of Birmingham
RP Zeegers, MP (corresponding author), Univ Birmingham, Dept Epidemiol & Publ Hlth, Unit Genet Epidemiol, Birmingham B15 2TT, W Midlands, England.
EM m.p.zeegers@bham.ac.uk
RI Ewer, Andrew/B-1050-2013; Thangaratinam, Shakila/AAP-3724-2021; Barrett,
   Timothy/F-1682-2010; Khan, Khalid Saeed/AAT-8824-2020
OI Ewer, Andrew/0000-0002-3825-4781; Cox, Phillip/0000-0002-4636-5668;
   Barrett, Timothy/0000-0002-6873-0750; Khan, Khalid
   Saeed/0000-0001-5084-7312; Thangaratinam, Shakila/0000-0002-4254-460X
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NR 34
TC 1
Z9 1
U1 0
U2 10
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 1832-4274
EI 1839-2628
J9 TWIN RES HUM GENET
JI Twin Res. Hum. Genet.
PD DEC
PY 2006
VL 9
IS 6
BP 907
EP 912
PG 6
WC Genetics & Heredity; Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Genetics & Heredity; Obstetrics & Gynecology
GA 122HO
UT WOS:000243216600036
PM 17254429
DA 2025-06-11
ER

PT J
AU Camp, OG
   Moussa, DN
   Hsu, R
   Awonuga, AO
   Abu-Soud, HM
AF Camp, Olivia G.
   Moussa, Daniel N.
   Hsu, Richard
   Awonuga, Awoniyi O.
   Abu-Soud, Husam M.
TI The interplay between oxidative stress, zinc, and metabolic dysfunction
   in polycystic ovarian syndrome
SO MOLECULAR AND CELLULAR BIOCHEMISTRY
LA English
DT Review
DE Polycystic Ovary Syndrome/PCOS; Oxidative stress; Zinc; Metabolic
   syndrome; Insulin resistance
ID TRACE-ELEMENT CONCENTRATIONS; INSULIN-RESISTANCE; SUPEROXIDE-DISMUTASE;
   SKELETAL-MUSCLE; DOUBLE-BLIND; WOMEN; SUPPLEMENTATION; MITOCHONDRIA;
   TRANSPORTERS; INFLAMMATION
AB Polycystic ovarian syndrome (PCOS) is a functional endocrine disorder characterized by hyperandrogenism, ovulatory dysfunction, and polycystic ovarian morphology that has been associated with chronic disease and comorbidities including adverse metabolic and cardiac disorders. This review aims to evaluate the role of oxidative stress and zinc in the metabolic dysfunction observed in PCOS, with a focus on insulin resistance. Recent studies indicate that oxidative stress markers are elevated in PCOS and correlate with hyperandrogenemia, obesity, and insulin resistance. Zinc, an essential trace element, is crucial for metabolic processes, particularly in the pancreas for beta-cell function and glucagon secretion. Insufficient zinc levels have been linked to diabetes, obesity, and lipid metabolism disorders. This review aims to highlight the interplay between oxidative stress, zinc, and metabolic dysfunction in PCOS, suggesting that zinc supplementation could mitigate some metabolic and endocrine manifestations of PCOS.
C1 [Camp, Olivia G.; Moussa, Daniel N.; Hsu, Richard; Awonuga, Awoniyi O.; Abu-Soud, Husam M.] Wayne State Univ, Sch Med, CS Mott Ctr Human Growth & Dev, Dept Obstet & Gynecol, Detroit, MI 48201 USA.
   [Abu-Soud, Husam M.] Wayne State Univ, Sch Med, Dept Physiol, Detroit, MI 48201 USA.
   [Abu-Soud, Husam M.] Wayne State Univ, Sch Med, Dept Microbiol Immunol & Biochem, Detroit, MI 48201 USA.
C3 Wayne State University; Wayne State University; Wayne State University
RP Abu-Soud, HM (corresponding author), Wayne State Univ, Sch Med, CS Mott Ctr Human Growth & Dev, Dept Obstet & Gynecol, Detroit, MI 48201 USA.; Abu-Soud, HM (corresponding author), Wayne State Univ, Sch Med, Dept Physiol, Detroit, MI 48201 USA.; Abu-Soud, HM (corresponding author), Wayne State Univ, Sch Med, Dept Microbiol Immunol & Biochem, Detroit, MI 48201 USA.
EM habusoud@med.wayne.edu
OI Camp, Olivia/0000-0002-7015-4895
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NR 77
TC 1
Z9 1
U1 2
U2 4
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0300-8177
EI 1573-4919
J9 MOL CELL BIOCHEM
JI Mol. Cell. Biochem.
PD APR
PY 2025
VL 480
IS 4
BP 2015
EP 2023
DI 10.1007/s11010-024-05113-x
EA SEP 2024
PG 9
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA 0VY8Z
UT WOS:001310620200001
PM 39266804
DA 2025-06-11
ER

PT J
AU Alexandru, N
   Popov, D
   Georgescu, A
AF Alexandru, Nicoleta
   Popov, Doina
   Georgescu, Adriana
TI Intraplatelet Oxidative/Nitrative Stress: Inductors, Consequences, and
   Control
SO TRENDS IN CARDIOVASCULAR MEDICINE
LA English
DT Review
AB This article provides an overview of the current knowledge on intraplatelet oxidative/nitrative stress, an abnormality associated with platelet activation and hyper-reactivity. The first issue discussed is related to induction of platelet endogenous stress by the molecules present within the circulating (extracellular) milieu that bathes these cells. The second issue concerns the intra platelet oxidative/nitrative stress associated with specific pathologies or clinical procedures and action of particular molecules and platelet agonists as well as of the specialized intraplatelet milieu and its redox system; the biomarkers of endogenous oxidative/nitrative stress are also briefly outlined. Next, the association between intraplatelet oxidative/nitrative stress and the risk factors of the metabolic syndrome is presented. Then, the most recent strategies aimed at the control/regulation of platelet endogenous oxidative/nitrative stress, such as exploitation of circulating extracellular reactive oxygen species scavengers, manipulation of platelet molecules, and the use of antioxidants, are discussed. Finally, the results of studies on platelet-dependent redox mechanisms, which deserve immediate attention for potential clinical exploitation, are illustrated. (Trends Cardiovasc Med 2010;20:232-238) (C) 2010 Elsevier Inc. All rights reserved.
C1 [Alexandru, Nicoleta; Georgescu, Adriana] Romanian Acad, Inst Cellular Biol & Pathol Nicolae Simionescu, Dept Cellular Physiol & Pharmacol, Bucharest 050568, Romania.
   [Alexandru, Nicoleta; Georgescu, Adriana] Petru Poni Inst Macromol Chem, Iasi 700487, Romania.
C3 Romanian Academy; Nicolae Simionescu Institute of Cellular Biology &
   Pathology; Romanian Academy; Petru Poni Institute of Macromolecular
   Chemistry
RP Alexandru, N (corresponding author), Romanian Acad, Inst Cellular Biol & Pathol Nicolae Simionescu, Dept Cellular Physiol & Pharmacol, 8,BP Hasdeu St,POB 35-14, Bucharest 050568, Romania.
EM nicoleta.alexandru@icbp.ro; adriana.georgescu@icbp.ro
RI L, Popov/AAY-5640-2020; Georgescu, Adriana/B-9185-2011; Alexandru-Moise,
   Nicoleta/E-5689-2011
OI Georgescu, Adriana/0000-0003-4945-1745
FU Romanian Ministry of Education, Research Youth and Sport; National
   Program for Research-Development and Innovation; National Authority for
   Scientific Research [1159/19.01.2009, 1043/2008]; National Centre for
   Programs' Management (CNMP) [42138/1.10.2008, 3334/2008]; European
   Social Fund [ID POSDRU/89/1.5/S/55216]; Romanian Academy
FX The authors' research is supported by grants from the Romanian Ministry
   of Education, Research Youth and Sport, including National Program for
   Research-Development and Innovation 2 (PNCDI-2); The National Authority
   for Scientific Research, Idea Program 1-Funding Application for
   Exploratory Research Projects (grant 1159/19.01.2009, PNII-IDEI code
   1043/2008); PNCDI-2, National Centre for Programs' Management (CNMP),
   Partnerships Program 4, Direction 4-Health (grant 42138/1.10.2008, code
   3334/2008); the European Social Fund-"Cristofor I. Simionescu"
   Postdoctoral Fellowship Program (ID POSDRU/89/1.5/S/55216); Sectoral
   Operational Program Human Resources Development 2007-2013; and by the
   Romanian Academy.
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NR 62
TC 9
Z9 9
U1 1
U2 4
PU ELSEVIER SCIENCE LONDON
PI LONDON
PA 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND
SN 1050-1738
J9 TRENDS CARDIOVAS MED
JI Trends Cardiovasc. Med.
PD OCT
PY 2010
VL 20
IS 7
BP 232
EP 238
AR PII S1050-1738(11)00086-7
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA V21PR
UT WOS:000208220000005
PM 22293024
DA 2025-06-11
ER

PT J
AU Keane, KN
   Cruzat, VF
   Carlessi, R
   de Bittencourt, PIH
   Newsholme, P
AF Keane, Kevin Noel
   Cruzat, Vinicius Fernandes
   Carlessi, Rodrigo
   Homem de Bittencourt, Paulo Ivo, Jr.
   Newsholme, Philip
TI Molecular Events Linking Oxidative Stress and Inflammation to Insulin
   Resistance and β-Cell Dysfunction
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Review
ID ENDOPLASMIC-RETICULUM STRESS; NF-KAPPA-B; SUPEROXIDE-DISMUTASE
   EXPRESSION; ISLET-ASSOCIATED MACROPHAGES; UNFOLDED PROTEIN RESPONSE;
   CULTURED RAT ADIPOCYTES; LOW-DENSITY-LIPOPROTEIN; REACTIVE OXYGEN; ER
   STRESS; NUTRIENT REGULATION
AB The prevalence of diabetes mellitus (DM) is increasing worldwide, a consequence of the alarming rise in obesity and metabolic syndrome (MetS). Oxidative stress and inflammation are key physiological and pathological events linking obesity, insulin resistance, and the progression of type 2 DM (T2DM). Unresolved inflammation alongside a "glucolipotoxic" environment of the pancreatic islets, in insulin resistant pathologies, enhances the infiltration of immune cells which through secretory activity cause dysfunction of insulin-secreting beta-cells and ultimately cell death. Recent molecular investigations have revealed that mechanisms responsible for insulin resistance associated with T2DM are detected in conditions such as obesity and MetS, including impaired insulin receptor (IR) signalling in insulin responsive tissues, oxidative stress, and endoplasmic reticulum (ER) stress. The aim of the present review is to describe the evidence linking oxidative stress and inflammation with impairment of insulin secretion and action, which result in the progression of T2DM and other conditions associated with metabolic dysregulation.
C1 [Keane, Kevin Noel; Cruzat, Vinicius Fernandes; Carlessi, Rodrigo; Newsholme, Philip] Curtin Univ, Sch Biomed Sci, Curtin Hlth Innovat Res Inst, Biosci, Perth, WA 6102, Australia.
   [Cruzat, Vinicius Fernandes] Univ Sao Paulo, Dept Physiol & Biophys, Inst Biomed Sci, Sao Paulo, SP, Brazil.
   [Carlessi, Rodrigo] Univ Fed Rio Grande do Sul, Postgrad Program Med Sci Endocrinol, BR-90035003 Porto Alegre, RS, Brazil.
   [Homem de Bittencourt, Paulo Ivo, Jr.] Univ Fed Rio Grande do Sul, Inst Basic Hlth Sci, Dept Physiol, BR-90050170 Porto Alegre, RS, Brazil.
C3 Curtin University; Universidade de Sao Paulo; Institute Biomed Science,
   University Sao Paulo; Universidade Federal do Rio Grande do Sul;
   Universidade Federal do Rio Grande do Sul
RP Cruzat, VF (corresponding author), Curtin Univ, Sch Biomed Sci, Curtin Hlth Innovat Res Inst, Biosci, Perth, WA 6102, Australia.
EM vinifc@usp.br
RI Cruzat, Vinicius/HOF-1622-2023; Carlessi, Rodrigo/JCE-0678-2023; Homem
   de Bittencourt Jr., Paulo Ivo/D-1156-2011; Newsholme,
   Philip/D-4939-2016; Cruzat, Vinicius/I-6920-2013; Keane, Kevin
   N./M-3149-2017
OI Homem de Bittencourt Jr., Paulo Ivo/0000-0003-1907-3341; Carlessi,
   Rodrigo/0000-0003-0038-7391; Newsholme, Philip/0000-0002-0500-6984;
   Cruzat, Vinicius/0000-0001-9879-4985; Keane, Kevin
   N./0000-0001-6248-7705
FU Brazilian National Council for Scientific and Technological Development
   (CNPq) [402626/2012-5, 245562/2012-5, 150454/2015-5, 200164/2014-7]
FX The authors thank Curtin University School of Biomedical Sciences for
   research support. This work was partially supported by grants from the
   Brazilian National Council for Scientific and Technological Development
   (CNPq) Science without Borders Programme: Special Visiting Scientist
   Fellowship to Philip Newsholme (no. 402626/2012-5), Postdoctoral
   Fellowship to Vinicius Fernandes Cruzat (nos. 245562/2012-5 and
   150454/2015-5), and Ph.D. Scholarship to Rodrigo Carlessi (no.
   200164/2014-7).
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NR 139
TC 289
Z9 313
U1 4
U2 34
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PY 2015
VL 2015
AR 181643
DI 10.1155/2015/181643
PG 15
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA CN6DI
UT WOS:000358523400001
PM 26257839
OA Green Published, Green Submitted, hybrid
DA 2025-06-11
ER

PT J
AU Aydos, LR
   do Amaral, LA
   Jacobowski, AC
   de Souza, RS
   Parisotto, EB
   de Menezes, MB
   Bittencourt, FF
   Fernandes, ES
   Silva, IS
   Portugal, LC
   Oliveira, CG
   Masuko, GTS
   Cavalheiro, LF
   Nazário, CED
   dos Santos, EF
   Macedo, MLR
AF Aydos, Leonardo Recena
   do Amaral, Luane Aparecida
   Jacobowski, Ana Cristina
   de Souza, Roberta Serafim
   Parisotto, Eduardo Benedetti
   de Menezes, Mariana Biava
   Bittencourt Junior, Felipe Francisco
   Fernandes, Emely Schuindt
   Silva, Iandara Schettert
   Portugal, Luciane Candeloro
   Oliveira, Claudio Goncalves
   Senra Masuko, Gustavo Tsuyoshi
   Cavalheiro, Leandro Fontoura
   Domingues Nazario, Carlos Eduardo
   dos Santos, Elisvania Freitas
   Rodrigues Macedo, Maria Ligia
TI Buriti pulp oil did not improve high-fat diet-induced metabolic
   disorders in c57bl/6 mice
SO JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION
LA English
DT Article
DE high&#8208; fat diet; metabolic syndrome; obesity
ID MAURITIA-FLEXUOSA L.; OXIDATIVE STRESS; LIVER-DISEASE; INFLAMMATION;
   DEPOSITION
AB Metabolic syndrome (MetS) and obesity are growing in many parts of the world, becoming public health problems. It is proposed that foods with functional properties can assist in the treatment of these diseases. Crude buriti pulp oil (BPO) is a food traditionally consumed by residents in the Pantanal, Cerrado and Brazilian Amazon. It is rich in oleic acid, tocopherols and carotenoids, emerging as a potential functional food. Thus, this study aimed to evaluate the effect of the supplementation of BPO on metabolic disorders caused by a high-fat diet. Four groups of C57BL6 mice were used, a lean group with AIN-93M diet and control oil supplementation, an obese group with a high-fat diet and control oil supplementation, and two obese groups with a high-fat diet and BPO supplementation in the amounts of 50 and 100 mg/kg. BPO worsened the metabolic state caused by the high-fat diet, worsening risk factors associated with MetS, as the abdominal circumference and retroperitoneal fat, serum levels of total cholesterol, uric acid, alanine transaminase, glucose and triglycerides, and renal fat, in addition to changes in glycaemic control and oxidative stress markers. C57BL/6 mice fed with a high-fat diet and supplemented with BPO presented a worsening in metabolic risk factors associated with MetS.
C1 [Aydos, Leonardo Recena; do Amaral, Luane Aparecida; de Souza, Roberta Serafim] Fed Univ Mato Grosso do Sul UFMS, Fac Med FAMED, Postgrad Program Hlth & Dev Midwest Reg, Campo Grande, MS, Brazil.
   [Aydos, Leonardo Recena; Jacobowski, Ana Cristina; de Souza, Roberta Serafim; Rodrigues Macedo, Maria Ligia] Fed Univ Mato Grosso do Sul UFMS, Prot Purificat Lab & Its Biol Funct LPPFB, Campo Grande, MS, Brazil.
   [Aydos, Leonardo Recena; do Amaral, Luane Aparecida; de Souza, Roberta Serafim; Silva, Iandara Schettert; Senra Masuko, Gustavo Tsuyoshi] Fed Univ Mato Grosso do Sul UFMS, Fac Med, Campo Grande, MS, Brazil.
   [Jacobowski, Ana Cristina; Parisotto, Eduardo Benedetti; de Menezes, Mariana Biava; dos Santos, Elisvania Freitas; Rodrigues Macedo, Maria Ligia] Fed Univ Mato Grosso do Sul UFMS, Fac Pharmaceut Sci Food & Nutr FACFAN, Campo Grande, MS, Brazil.
   [Bittencourt Junior, Felipe Francisco; Fernandes, Emely Schuindt] Univ Ctr Grande Dourados UNIGRAN, Fac Biol & Hlth Sci, Dourados, MS, Brazil.
   [Bittencourt Junior, Felipe Francisco; Fernandes, Emely Schuindt] Univ Ctr Grande Dourados UNIGRAN, Clin Anal Lab, Dourados, MS, Brazil.
   [Silva, Iandara Schettert] Fed Univ Mato Grosso do Sul UFMS, Lab Expt Dis Models, Campo Grande, MS, Brazil.
   [Portugal, Luciane Candeloro; Oliveira, Claudio Goncalves] Fed Univ Mato Grosso do Sul UFMS, Biosci Inst INBIO, Campo Grande, MS, Brazil.
   [Cavalheiro, Leandro Fontoura; Domingues Nazario, Carlos Eduardo] Fed Univ Mato Grosso do Sul UFMS, Inst Chem INQUI, Campo Grande, MS, Brazil.
C3 Universidade Federal de Mato Grosso do Sul; Universidade Federal de Mato
   Grosso do Sul; Universidade Federal de Mato Grosso do Sul; Universidade
   Federal de Mato Grosso do Sul; Universidade Federal de Mato Grosso do
   Sul; Universidade Federal de Mato Grosso do Sul; Universidade Federal de
   Mato Grosso do Sul
RP Aydos, LR (corresponding author), Fed Univ Mato Grosso do Sul UFMS, Fac Med FAMED, Postgrad Program Hlth & Dev Midwest Reg, Campo Grande, MS, Brazil.
EM leonardoaydos@gmail.com
RI Santos, Elisvania/AFV-3300-2022; Nazario, Carlos/G-9525-2012; Parisotto,
   Eduardo/V-5979-2019; Jacobowski, Ana Cristina/O-5045-2016; do Amaral,
   Luane Aparecida/K-4539-2018; Schettert Silva, Iandara/L-8525-2018
OI Jacobowski, Ana Cristina/0000-0001-8233-0713; Biava de Menezes,
   Mariana/0000-0001-5871-5285; Souza, Roberta/0000-0003-2538-6707; do
   Amaral, Luane Aparecida/0000-0002-1448-2472; Bittencourt Junior, Felipe
   Francisco/0000-0001-8801-9934; candeloro, luciane/0000-0001-9619-0010;
   Nazario, Carlos Eduardo Domingues/0000-0001-5097-3298; Schettert Silva,
   Iandara/0000-0001-9431-098X
FU Fundacao de Apoio ao Desenvolvimento do Ensino, Ciencia e Tecnologia do
   Estado de Mato Grosso do Sul; Coordenacao de Aperfeicoamento de Pessoal
   de Nivel Superior; Conselho Nacional de Desenvolvimento Cientifico e
   Tecnologico
FX Fundacao de Apoio ao Desenvolvimento do Ensino, Ciencia e Tecnologia do
   Estado de Mato Grosso do Sul; Coordenacao de Aperfeicoamento de Pessoal
   de Nivel Superior; Conselho Nacional de Desenvolvimento Cientifico e
   Tecnologico
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NR 49
TC 4
Z9 4
U1 0
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0931-2439
EI 1439-0396
J9 J ANIM PHYSIOL AN N
JI J. Anim. Physiol. Anim. Nutr.
PD MAR
PY 2021
VL 105
IS 2
BP 364
EP 375
DI 10.1111/jpn.13473
EA NOV 2020
PG 12
WC Agriculture, Dairy & Animal Science; Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture; Veterinary Sciences
GA QR0XN
UT WOS:000591399900001
PM 33226712
DA 2025-06-11
ER

PT J
AU Barazzoni, R
   Cappellari, GG
   Ragni, M
   Nisoli, E
AF Barazzoni, Rocco
   Cappellari, Gianluca Gortan
   Ragni, Maurizio
   Nisoli, Enzo
TI Insulin resistance in obesity: an overview of fundamental alterations
SO EATING AND WEIGHT DISORDERS-STUDIES ON ANOREXIA BULIMIA AND OBESITY
LA English
DT Review
DE Obesity; Insulin resistance; Inflammation; Oxidative stress
ID BROWN ADIPOSE-TISSUE; MUSCLE OXIDATIVE CAPACITY; HUMAN SKELETAL-MUSCLE;
   TUMOR-NECROSIS-FACTOR; HIGH-FAT DIET; MITOCHONDRIAL DYSFUNCTION; GUT
   MICROBIOTA; ADIPONECTIN EXPRESSION; MOLECULAR-MECHANISMS; METABOLIC
   SYNDROME
AB Obesity is a major health risk factor, and obesity-induced morbidity and complications account for huge costs for affected individuals, families, healthcare systems, and society at large. In particular, obesity is strongly associated with the development of insulin resistance, which in turn plays a key role in the pathogenesis of obesity-associated cardiometabolic complications, including metabolic syndrome components, type 2 diabetes, and cardiovascular diseases. Insulin sensitive tissues, including adipose tissue, skeletal muscle, and liver, are profoundly affected by obesity both at biomolecular and functional levels. Altered adipose organ function may play a fundamental pathogenetic role once fat accumulation has ensued. Modulation of insulin sensitivity appears to be, at least in part, related to changes in redox balance and oxidative stress as well as inflammation, with a relevant underlying role for mitochondrial dysfunction that may exacerbate these alterations. Nutrients and substrates as well as systems involved in host-nutrient interactions, including gut microbiota, have been also identified as modulators of metabolic pathways controlling insulin action. This review aims at providing an overview of these concepts and their potential inter-relationships in the development of insulin resistance, with particular regard to changes in adipose organ and skeletal muscle.
C1 [Barazzoni, Rocco; Cappellari, Gianluca Gortan] Univ Trieste, Dept Med Surg & Hlth Sci, Str Fiume 447, I-34149 Trieste, Italy.
   [Barazzoni, Rocco; Cappellari, Gianluca Gortan] Azienda Sanit Univ Integrata Trieste ASUITS, Trieste, Italy.
   [Ragni, Maurizio; Nisoli, Enzo] Univ Milan, Ctr Study & Res Obes, Dept Med Biotechnol & Translat Med, Via Vanvitelli 32, I-20129 Milan, Italy.
C3 University of Trieste; University of Trieste; University Trieste
   Hospital; University of Milan
RP Barazzoni, R (corresponding author), Univ Trieste, Dept Med Surg & Hlth Sci, Str Fiume 447, I-34149 Trieste, Italy.; Barazzoni, R (corresponding author), Azienda Sanit Univ Integrata Trieste ASUITS, Trieste, Italy.; Nisoli, E (corresponding author), Univ Milan, Ctr Study & Res Obes, Dept Med Biotechnol & Translat Med, Via Vanvitelli 32, I-20129 Milan, Italy.
EM barazzon@units.it; enzo.nisoli@unimi.it
RI Nisoli, Enzo/D-6526-2014; Cappellari, Gianluca/B-7132-2013; Ragni,
   Maurizio/AAB-1527-2020
OI Gortan Cappellari, Gianluca/0000-0002-0438-5003; Ragni,
   Maurizio/0000-0001-6548-741X
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NR 97
TC 247
Z9 271
U1 9
U2 110
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1124-4909
EI 1590-1262
J9 EAT WEIGHT DISORD-ST
JI Eat. Weight Disord.-Stud. Anorex.
PD APR
PY 2018
VL 23
IS 2
BP 149
EP 157
DI 10.1007/s40519-018-0481-6
PG 9
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychiatry
GA GA1NG
UT WOS:000428082700002
PM 29397563
OA Green Submitted
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Bulló, M
   Lamuela-Raventós, R
   Salas-Salvadó, J
AF Bullo, Monica
   Lamuela-Raventos, Rosa
   Salas-Salvado, Jordi
TI Mediterranean Diet and Oxidation: Nuts and Olive Oil as Important
   Sources of Fat and Antioxidants
SO CURRENT TOPICS IN MEDICINAL CHEMISTRY
LA English
DT Review
DE Nuts; virgin olive oil; oxidative stress; antioxidants; mediterranean
   diet
ID LOW-DENSITY-LIPOPROTEIN; CORONARY-HEART-DISEASE; MINOR-POLAR-COMPOUNDS;
   FACTOR-KAPPA-B; PLATELET-AGGREGATION; PHENOLIC-COMPOUNDS; DNA-DAMAGE;
   ENDOTHELIAL FUNCTION; ALPHA-TOCOPHEROL; LIPID PROFILE
AB Oxidative stress has been involved in the aetiology of hypertension, insulin resistance, the metabolic syndrome, cardiovascular disease and other chronic conditions. Several epidemiological studies suggest that a diet rich in natural antioxidants is associated with protective effects against major diseases, especially cardiovascular disease. The Mediterranean diet is rich in fat and foods with important antioxidant properties, such as fruits and vegetables, olive oil, and nuts. In this review we focus on epidemiological evidence and clinical trials that relate the Mediterranean diet with oxidative stress markers. We focus our review on two important Mediterranean vegetable sources of potentially oxidized fat-olive oil and nuts.
C1 [Bullo, Monica; Salas-Salvado, Jordi] Univ Rovira & Virgili, Hosp Univ St Joan, Dept Bioquim & Biotecnol, Unitat Nutr Humana,IISPV, E-43201 Reus, Spain.
   [Lamuela-Raventos, Rosa] Univ Barcelona, Fac Farm, Dept Nutr & Bromatol, E-08028 Barcelona, Spain.
   [Bullo, Monica; Lamuela-Raventos, Rosa; Salas-Salvado, Jordi] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr CB06 03, Madrid, Spain.
C3 Universitat Rovira i Virgili; Institut d'Investigacio Sanitaria Pere
   Virgili (IISPV); University of Barcelona; Instituto de Salud Carlos III;
   CIBER - Centro de Investigacion Biomedica en Red; CIBEROBN
RP Salas-Salvadó, J (corresponding author), Univ Rovira & Virgili, Human Nutr Unit, Fac Med, C St Llorenc 21, E-43201 Reus, Spain.
EM jordi.salas@urv.cat
RI Bullo, Monica/F-2925-2016; Salas-Salvado, Jordi/C-7229-2017;
   Lamuela-Raventos, Rosa M/F-3986-2016
OI Bullo, Monica/0000-0002-0218-7046; Salas-Salvado,
   Jordi/0000-0003-2700-7459; Lamuela-Raventos, Rosa M/0000-0002-1287-4560
FU Spanish Ministry of Health (Instituto de Salud Carlos III) [G03/140,
   RD06/0045]; Centre Catala de la Nutricio (CCNIEC), Institut d'Estudis
   Catalans, Barcelona, Spain; Spanish Ministry of Health (Instituto de
   Salud Carlos III, Fondo de Investigaciones Sanitarias) [G03/140,
   RD06/0045, PI051839, CB06/03]
FX This study was funded, in part, by the Spanish Ministry of Health
   (Instituto de Salud Carlos III), G03/140, and RD06/0045, and the Centre
   Catala de la Nutricio (CCNIEC), Institut d'Estudis Catalans, Barcelona,
   Spain. This study was partly funded by the Spanish Ministry of Health
   (Instituto de Salud Carlos III, Fondo de Investigaciones Sanitarias)
   under projects PI051839, G03/140, RD06/0045 and CB06/03. CIBERobn is an
   Instituto de Salud Carlos III initiative.
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NR 157
TC 131
Z9 141
U1 1
U2 56
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1568-0266
EI 1873-5294
J9 CURR TOP MED CHEM
JI Curr. Top. Med. Chem.
PD JUL
PY 2011
VL 11
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BP 1797
EP 1810
DI 10.2174/156802611796235062
PG 14
WC Chemistry, Medicinal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 792PO
UT WOS:000292759700005
PM 21506929
DA 2025-06-11
ER

PT J
AU Mollace, R
   Macrì, R
   Tavernese, A
   Gliozzi, M
   Musolino, V
   Carresi, C
   Maiuolo, J
   Fini, M
   Volterrani, M
   Mollace, V
AF Mollace, Rocco
   Macri, Roberta
   Tavernese, Annamaria
   Gliozzi, Micaela
   Musolino, Vincenzo
   Carresi, Cristina
   Maiuolo, Jessica
   Fini, Massimo
   Volterrani, Maurizio
   Mollace, Vincenzo
TI Comparative Effect of Bergamot Polyphenolic Fraction and Red Yeast Rice
   Extract in Rats Fed a Hyperlipidemic Diet: Role of Antioxidant
   Properties and PCSK9 Expression
SO NUTRIENTS
LA English
DT Article
DE hypercholesterolemia; red yeast rice (RYR); bergamot polyphenolic
   fraction (BPF); malondialdehyde (MDA); oxidative stress; proprotein
   convertase subtilisin; kexin type 9 (PCSK9)
ID LDL-CHOLESTEROL; ENDOTHELIAL DYSFUNCTION; CLINICAL-EFFICACY; OXIDATIVE
   STRESS; SAFETY; INFLAMMATION; METAANALYSIS; ASSOCIATION; PREVENTION;
   STATINS
AB Elevated serum cholesterol levels, either associated or not with increased triglycerides, represent a risk of developing vascular injury, mostly leading to atherothrombosis-related diseases including myocardial infarction and stroke. Natural products have been investigated in the last few decades as they are seen to offer an alternative solution to counteract cardiometabolic risk, due to the occurrence of side effects with the use of statins, the leading drugs for treating hyperlipidemias. Red yeast rice (RYR), a monacolin K-rich natural extract, has been found to be effective in counteracting high cholesterol, being its use accompanied by consistent warnings by regulatory authorities based on the potential detrimental responses accompanying its statin-like chemical charcateristics. Here we compared the effects of RYR with those produced by bergamot polyphenolic fraction (BPF), a well-known natural extract proven to be effective in lowering both serum cholesterol and triglycerides in animals fed a hyperlipidemic diet. In particular, BPF at doses of 10 mg/Kg given orally for 30 consecutive days, counteracted the elevation of both serum LDL cholesterol (LDL-C) and triglycerides induced by the hyperlipidemic diet, an effect which was accompanied by significant reductions of malondialdehyde (MDA) and glutathione peroxidase serum levels, two biomarkers of oxidative stress. Furthermore, the activity of BPF was associated to increased HDL cholesterol (HDL-C) levels and to strong reduction of Proprotein convertase subtilisin/kexin type 9 (PCSK9) levels which were found increased in hyperlipidemic rats. In contrast, RYR at doses of 1 and 3 mg/Kg, produced only significant reduction of LDL-C with very poor effects on triglycerides, HDL-C, glutathione peroxidase, MDA and PCSK9 expression. This indicates that while BPF and RYR both produce serum cholesterol-lowering benefits, BPF produces additional effects on triglycerides and HDL cholesterol compared to RYR at the doses used throughout the study. These additional effects of BPF appear to be related to the reduction of PCSK9 expression and to the antioxidant properties of this extract compared to RYR, thereby suggesting a more complete protection from cardiometabolic risk.
C1 [Mollace, Rocco; Macri, Roberta; Tavernese, Annamaria; Gliozzi, Micaela; Musolino, Vincenzo; Carresi, Cristina; Maiuolo, Jessica; Fini, Massimo; Volterrani, Maurizio; Mollace, Vincenzo] Magna Graecia Univ Catanzaro, Dept Hlth Sci, Inst Res Food Safety & Hlth IRC FSH, I-88100 Catanzaro, Italy.
   [Mollace, Rocco; Fini, Massimo; Volterrani, Maurizio; Mollace, Vincenzo] IRCCS San Raffaele Pisana, Via Valcannuta, I-88163 Rome, Italy.
C3 Magna Graecia University of Catanzaro; IRCCS San Raffaele Pisana
RP Mollace, V (corresponding author), Magna Graecia Univ Catanzaro, Dept Hlth Sci, Inst Res Food Safety & Hlth IRC FSH, I-88100 Catanzaro, Italy.; Mollace, V (corresponding author), IRCCS San Raffaele Pisana, Via Valcannuta, I-88163 Rome, Italy.
EM rocco.mollace@gmail.com; robertamacri85@gmail.com;
   an.tavernese@gmail.com; micaela.gliozzi@gmail.com; xabaras3@hotmail.com;
   carresi@unicz.it; jessicamaiuolo@virgilio.it;
   massimo.fini@sanraffaele.it; maurizio.volterrani@sanraffaele.it;
   mollace@libero.it
RI MACRI', Roberta/AAC-5967-2022; Musolino, Vincenzo/AAC-6429-2022;
   Maiuolo, Jessica/AAU-2482-2020; Gliozzi, Micaela/D-4405-2015; carresi,
   cristina/AAC-6354-2022; Mollace, Rocco/ABH-5643-2020; volterrani,
   maurizio/K-5919-2016
OI Mollace, Rocco/0000-0002-7106-5595; volterrani,
   maurizio/0000-0002-2624-9213; MACRI', Roberta/0000-0002-2345-6751;
   Musolino, Vincenzo/0000-0002-4763-2211; tavernese,
   annamaria/0000-0002-2940-3482; mollace, vincenzo/0000-0002-0392-7173
FU Italian Ministry of Research [PON-MIUR 03PE000_78_1, PON-MIUR
   03PE000_78_2]
FX The work was supported by the public resources from the Italian Ministry
   of Research: PON-MIUR 03PE000_78_1 and PONMIUR 03PE000_78_2. POR
   Calabria FESR FSE 2014-2020 Asse 12-Azioni 10.5.6 e 10.5.12.
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NR 45
TC 14
Z9 14
U1 0
U2 12
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD FEB
PY 2022
VL 14
IS 3
AR 477
DI 10.3390/nu14030477
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA ZC3OL
UT WOS:000757433400001
PM 35276836
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Wolf, EJ
   Morrison, FG
AF Wolf, Erika J.
   Morrison, Filomene G.
TI Traumatic Stress and Accelerated Cellular Aging: From Epigenetics to
   Cardiometabolic Disease
SO CURRENT PSYCHIATRY REPORTS
LA English
DT Review
DE Traumatic stress; PTSD; Accelerated aging; Epigenetic clock;
   Inflamm-aging; Immunosenescence
ID LEUKOCYTE TELOMERE LENGTH; DNA METHYLATION AGE; ALL-CAUSE MORTALITY;
   METABOLIC SYNDROME; DISORDER SYMPTOMS; OXIDATIVE STRESS;
   PSYCHIATRIC-DISORDERS; ALZHEIMERS-DISEASE; CORTICAL THICKNESS; CLOCK
   ANALYSIS
AB Purpose of Review The aim of this paper is to review the recent literature on traumatic stress-related accelerated aging, including a focus on cellular mechanisms and biomarkers of cellular aging and on the clinical manifestations of accelerated biological aging.
   Recent Findings Multiple lines of research converge to suggest that PTSD is associated with accelerated aging in the epigenome, and the immune and inflammation systems, and this may be reflected in premature onset of cardiometabolic and cardiovascular disease.
   Summary The current state of research paves the way for future work focused on identifying the peripheral and central biological mechanisms linking traumatic stress to accelerated biological aging and medical morbidity, with an emphasis on processes involved in inflammation, immune functioning, oxidative stress, autonomic arousal, and stress response. Ultimately, such work could help reduce the pace of biological aging and improve health and wellness.
C1 [Wolf, Erika J.] VA Boston Healthcare Syst, Natl Ctr PTSD, 116B-2,150 South Huntington Ave, Boston, MA 02130 USA.
   [Wolf, Erika J.] Boston Univ, Sch Med, Dept Psychiat, Boston, MA 02118 USA.
   [Morrison, Filomene G.] Harvard Med Sch, McLean Hosp, Belmont, MA USA.
C3 Harvard University; Harvard University Medical Affiliates; US Department
   of Veterans Affairs; Veterans Health Administration (VHA); VA Boston
   Healthcare System; Boston University; Harvard University; Harvard
   University Medical Affiliates; McLean Hospital
RP Wolf, EJ (corresponding author), VA Boston Healthcare Syst, Natl Ctr PTSD, 116B-2,150 South Huntington Ave, Boston, MA 02130 USA.; Wolf, EJ (corresponding author), Boston Univ, Sch Med, Dept Psychiat, Boston, MA 02118 USA.
EM erika.wolf@va.gov
OI Wolf, Erika/0000-0003-2666-2435
FU National Institute on Aging of the National Institutes of Health
   [R03AG051877]; Merit Review Award from the US Department of Veterans
   Affairs (VA) Clinical Sciences Research and Development (CSRD) Service
   [I01 CX-001276-01]; Presidential Early Career Award for Scientists and
   Engineers [PECASE 2013A]
FX This work was supported in part by the National Institute on Aging of
   the National Institutes of Health award R03AG051877 to EJW and by Merit
   Review Award Number I01 CX-001276-01 to EJW from the US Department of
   Veterans Affairs (VA) Clinical Sciences Research and Development (CSRD)
   Service. This work was also supported by a Presidential Early Career
   Award for Scientists and Engineers (PECASE 2013A) to EJW as administered
   by the US Department of VA Office of Research and Development.
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NR 106
TC 59
Z9 61
U1 2
U2 28
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1523-3812
EI 1535-1645
J9 CURR PSYCHIAT REP
JI Curr. Psychiatry Rep.
PD OCT
PY 2017
VL 19
IS 10
AR 75
DI 10.1007/s11920-017-0823-5
PG 12
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA FH4WJ
UT WOS:000411162700010
PM 28852965
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Tyagi, A
   Pugazhenthi, S
AF Tyagi, Alpna
   Pugazhenthi, Subbiah
TI A Promising Strategy to Treat Neurodegenerative Diseases by SIRT3
   Activation
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE SIRT3; longevity; mitochondria; metabolism; oxidative stress;
   neurodegeneration; metabolic syndrome; Alzheimer's disease
ID INSULIN-DEGRADING ENZYME; MITOCHONDRIAL SIRT3; ALZHEIMERS-DISEASE;
   SKELETAL-MUSCLE; CALORIE RESTRICTION; OXIDATIVE STRESS; COGNITIVE
   IMPAIRMENT; ENERGY-METABOLISM; DEACETYLASE SIRT3; PROTECTS
AB SIRT3, the primary mitochondrial deacetylase, regulates the functions of mitochondrial proteins including metabolic enzymes and respiratory chain components. Although SIRT3's functions in peripheral tissues are well established, the significance of its downregulation in neurodegenerative diseases is beginning to emerge. SIRT3 plays a key role in brain energy metabolism and provides substrate flexibility to neurons. It also facilitates metabolic coupling between fuel substrate-producing tissues and fuel-consuming tissues. SIRT3 mediates the health benefits of lifestyle-based modifications such as calorie restriction and exercise. SIRT3 deficiency is associated with metabolic syndrome (MetS), a precondition for diseases including obesity, diabetes, and cardiovascular disease. The pure form of Alzheimer's disease (AD) is rare, and it has been reported to coexist with these diseases in aging populations. SIRT3 downregulation leads to mitochondrial dysfunction, neuroinflammation, and inflammation, potentially triggering factors of AD pathogenesis. Recent studies have also suggested that SIRT3 may act through multiple pathways to reduce plaque formation in the AD brain. In this review, we give an overview of SIRT3's roles in brain physiology and pathology and discuss several activators of SIRT3 that can be considered potential therapeutic agents for the treatment of dementia.
C1 [Tyagi, Alpna; Pugazhenthi, Subbiah] Rocky Mt Reg VA Med Ctr, Aurora, CO 80045 USA.
   [Tyagi, Alpna; Pugazhenthi, Subbiah] Univ Colorado Anschutz Med Campus, Dept Med, Aurora, CO 80045 USA.
C3 University of Colorado System; University of Colorado Anschutz Medical
   Campus
RP Pugazhenthi, S (corresponding author), Rocky Mt Reg VA Med Ctr, Aurora, CO 80045 USA.; Pugazhenthi, S (corresponding author), Univ Colorado Anschutz Med Campus, Dept Med, Aurora, CO 80045 USA.
EM subbiah.pugazhenthi@cuanschutz.edu
FU Veterans Administration [NURD-016-18F BX004480]
FX This study was supported by a Merit Review grant NURD-016-18F BX004480
   from the Veterans Administration (to S.P.).
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NR 190
TC 15
Z9 18
U1 3
U2 20
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD JAN
PY 2023
VL 24
IS 2
AR 1615
DI 10.3390/ijms24021615
PG 25
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 8C9GO
UT WOS:000917909100001
PM 36675125
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Çevikelli-Yakut, ZA
   Özçelik, R
   Çevik, Ö
   Sener, TE
   Sener, G
AF Cevikelli-Yakut, Zatiye Ayca
   Ozcelik, Reyhan
   Cevik, Ozge
   Sener, Tarik Emre
   Sener, Goksel
TI Exercise and caloric restriction improve cardiovascular and erectile
   function in rats with metabolic syndrome
SO INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH
LA English
DT Article
ID ENDOTHELIAL DYSFUNCTION; INSULIN-RESISTANCE; ORGAN DAMAGE; NITRIC-OXIDE;
   MELATONIN; PREVENTION; STRESS; MODEL
AB The aim of this study is to examine the possible benefits of exercise and caloric restriction (CR) on cardiovascular hemodynamics, erectile function, and antioxidant system in metabolic syndrome (MS). Sixty male Spraque-Dawley rats were divided into five groups; control, MS, MS + CR, MS + exercise (EXC), and MS + CR + EXC. To induce MS, 10% fructose solution was applied for 3 months. Thereafter, in CR groups calorie was restricted 40% and in EXC groups swimming was performed for 6 weeks. Body weight, blood glucose, and blood pressure (BP) levels were measured before and after MS induction and at the end of the experiment. After decapitation, tumor necrosis factor (TNF)-alpha, adiponectin (ADP), and plasminogen activator inhibitor (PAI)-1 levels were investigated in blood, oxidative stress parameters were examined in heart, aorta, and corpus cavernosum (CC) tissues. Isometric contraction in isolated tissue bath was studied in aorta and CC tissues. Animals subjected to exercise and CR had decreased BP and blood glucose levels. Impaired contraction-relaxation responses in MS group were improved with exercise and CR. MS-induced increase in TNF-alpha, PAI-1, malondialdehyde (MDA), and decrease in ADP, glutathione (GSH), and superoxide dismutase (SOD) were normalized with exercise and CR. Exercise and CR may be beneficial against changes in cardiovascular hemodynamics caused by MS.
C1 [Cevikelli-Yakut, Zatiye Ayca; Ozcelik, Reyhan; Sener, Goksel] Marmara Univ, Sch Pharm, Dept Pharmacol, Istanbul, Turkey.
   [Cevikelli-Yakut, Zatiye Ayca] Trakya Univ, Sch Pharm, Dept Pharmacognosy, Edirne, Turkey.
   [Cevik, Ozge] Adnan Menderes Univ, Sch Med, Dept Biochem, Aydin, Turkey.
   [Sener, Tarik Emre] Marmara Univ, Sch Med, Dept Urol, Istanbul, Turkey.
C3 Marmara University; Trakya University; Adnan Menderes University;
   Marmara University
RP Sener, G (corresponding author), Marmara Univ, Sch Pharm, Dept Pharmacol, Istanbul, Turkey.
EM gsener@marmara.edu.tr
RI Şener, Göksel/AAN-4461-2021; Yakut, Zatiye/AAF-7800-2021; Sener,
   Tarik/K-2501-2016; University, Aydin Adnan/Z-2790-2019
OI Sener, Goksel/0000-0001-7444-6193
FU Marmara University Scientific Research Projects Committee
   [SAG-C-YLP-090113-0002]
FX This study was supported by Marmara University Scientific Research
   Projects Committee with the grant number: SAG-C-YLP-090113-0002.
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NR 48
TC 8
Z9 10
U1 0
U2 13
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0955-9930
EI 1476-5489
J9 INT J IMPOT RES
JI Int. J. Impot. Res.
PD DEC
PY 2021
VL 33
IS 8
BP 844
EP 853
DI 10.1038/s41443-020-00356-w
EA OCT 2020
PG 10
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA YP9AK
UT WOS:000574730800002
PM 33009496
OA Bronze
DA 2025-06-11
ER

PT J
AU Zhang, L
   Bruce-Keller, AJ
   Dasuri, K
   Nguyen, A
   Liu, Y
   Keller, JN
AF Zhang, Le
   Bruce-Keller, Annadora J.
   Dasuri, Kalavathi
   Nguyen, AnhThao
   Liu, Ying
   Keller, Jeffrey N.
TI Diet-induced metabolic disturbances as modulators of brain homeostasis
SO BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
LA English
DT Review
DE Aging; Brain; Diabetes; Metabolic syndrome; Neuron; Oxidative stress
ID INCREASED OXIDATIVE STRESS; TYPE-2 DIABETES-MELLITUS;
   INSULIN-RESISTANCE; ALZHEIMERS-DISEASE; MITOCHONDRIAL BIOGENESIS;
   LIPID-PEROXIDATION; COGNITIVE DECLINE; INDUCED OBESITY; RISK-FACTORS;
   DYSFUNCTION
AB A number of metabolic disturbances occur in response to the consumption of a high fat western diet. Such metabolic disturbances can include the progressive development of hyperglycemia, hyperinsulemia, obesity, metabolic syndrome, and diabetes. Cumulatively, diet-induced disturbances in metabolism are known to promote increased morbidity and negatively impact life expectancy through a variety of mechanisms. While the impact of metabolic disturbances on the hepatic, endocrine, and cardiovascular systems is well established there remains a noticeable void in understanding the basis by which the central nervous system (CNS) becomes altered in response to diet-induced metabolic dysfunction. In particular, it remains to be fully elucidated which established features of diet-induced pathogenesis (observed in non-CNS tissues) are recapitulated in the brain, and identification as to whether the observed changes in the brain are a direct or indirect effect of peripheral metabolic disturbances. This review will focus on each of these key issues and identify some critical experimental questions which remain to be elucidated experimentally, as well as provide an outline of our current understanding for how diet-induced alterations in metabolism may impact the brain during aging and age-related diseases of the nervous system. (C) 2008 Published by Elsevier B.V.
C1 [Zhang, Le; Bruce-Keller, Annadora J.; Dasuri, Kalavathi; Nguyen, AnhThao; Liu, Ying; Keller, Jeffrey N.] Louisiana State Univ Syst, Pennington Biomed Res Ctr, Baton Rouge, LA 70808 USA.
C3 Louisiana State University System; Louisiana State University;
   Pennington Biomedical Research Center
RP Keller, JN (corresponding author), Louisiana State Univ Syst, Pennington Biomed Res Ctr, 6400 Perkins Rd, Baton Rouge, LA 70808 USA.
EM jeffrey.keller@pbrc.edu
RI DASURI, KALAVATHI/E-7381-2012; Keller, Jeffrey/N-1975-2017;
   Bruce-Keller, Annadora/N-1954-2017
OI keller, jeffrey/0000-0002-9892-7423; Zhang, Le/0000-0001-7730-9266
FU NIA [AG029885, AG025771, AG005119]; Hibernia National Bank/Edward G.
   Schlieder Endowed Chair for Research; Alzhiemer's Association
FX This work was supported by grants to J.N. K. from the NIA (AG029885,
   AG025771, AG005119), the Hibernia National Bank/Edward G. Schlieder
   Endowed Chair for Research, and the Alzhiemer's Association.
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NR 71
TC 39
Z9 46
U1 1
U2 6
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0925-4439
EI 1879-260X
J9 BBA-MOL BASIS DIS
JI Biochim. Biophys. Acta-Mol. Basis Dis.
PD MAY
PY 2009
VL 1792
IS 5
SI SI
BP 417
EP 422
DI 10.1016/j.bbadis.2008.09.006
PG 6
WC Biochemistry & Molecular Biology; Biophysics; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Cell Biology
GA 444CC
UT WOS:000265956700005
PM 18926905
OA Green Submitted, Green Accepted
DA 2025-06-11
ER

PT B
AU Pasquali, R
AF Pasquali, Renato
BE Cizza, G
   Rother, KI
TI The hypothalamic-pituitary-adrenal axis and sex hormones in chronic
   stress and obesity: pathophysiological and clinical aspects
SO BRAIN AND OBESITY
SE Annals of the New York Academy of Sciences-Series
LA English
DT Article; Book Chapter
DE cortisol; androgens; stress; obesity
ID PLASMA-CORTISOL LEVELS; BODY-FAT DISTRIBUTION; 11-BETA-HYDROXYSTEROID
   DEHYDROGENASE TYPE-1; CORTICOTROPIN-RELEASING-FACTOR; METABOLIC
   SYNDROME; ABDOMINAL OBESITY; ALLOSTATIC LOAD; ARGININE-VASOPRESSIN;
   INSULIN-RESISTANCE; ADIPOSE-TISSUE
AB Obesity, particularly the abdominal phenotype, has been ascribed to an individual maladaptation to chronic environmental stress exposure mediated by a dysregulation of related neuroendocrine axes. Alterations in the control and action of the hypothalamic-pituitary-adrenal axis play a major role in this context, with the participation of the sympathetic nervous system. The ability to adapt to chronic stress may differ according to sex, with specific pathophysiological events leading to the development of stress-related chronic diseases. This seems to be influenced by the regulatory effects of sex hormones, particularly androgens. Stress may also disrupt the control of feeding, with some differences according to sex. Finally, the amount of experimental data in both animals and humans may help to shed more light on specific phenotypes of obesity, strictly related to the chronic exposure to stress. This challenge may potentially imply a different pathophysiological perspective and, possibly, a specific treatment.
C1 Univ Alma Mater Studiorum Bologna, Div Endocrinol, Dept Clin Med, S Orsola Malpighi Hosp, I-40138 Bologna, Italy.
C3 University of Bologna; IRCCS Azienda Ospedaliero-Universitaria di
   Bologna
RP Pasquali, R (corresponding author), Univ Alma Mater Studiorum Bologna, Div Endocrinol, Dept Clin Med, S Orsola Malpighi Hosp, Via Massarenti 9, I-40138 Bologna, Italy.
EM renato.pasquali@unibo.it
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NR 140
TC 95
Z9 99
U1 1
U2 21
PU BLACKWELL SCIENCE PUBL
PI OXFORD
PA OSNEY MEAD, OXFORD OX2 0EL, ENGLAND
BN 978-1-57331-860-0
J9 ANN NY ACAD SCI
JI Ann.NY Acad.Sci.
PY 2012
VL 1264
BP 20
EP 35
DI 10.1111/j.1749-6632.2012.06569.x
PG 16
WC Endocrinology & Metabolism; Multidisciplinary Sciences; Neurosciences
WE Book Citation Index – Science (BKCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Science & Technology - Other Topics;
   Neurosciences & Neurology
GA BDB65
UT WOS:000312490600004
PM 22612409
OA Green Published
DA 2025-06-11
ER

PT J
AU Marik, PE
   Raghavan, M
AF Marik, PE
   Raghavan, M
TI Stress-hyperglycemia, insulin and immunomodulation in sepsis
SO INTENSIVE CARE MEDICINE
LA English
DT Review
DE insulin; glucose; sepsis; sepsis syndrome; critical illness; insulin
   resistance; hyperglycemia
ID FACTOR-KAPPA-B; ACUTE MYOCARDIAL-INFARCTION; TYROSINE KINASE-ACTIVITY;
   ADMISSION PLASMA-GLUCOSE; INDEPENDENT RISK-FACTOR; CRITICALLY-ILL
   PATIENTS; MONONUCLEAR-CELLS MNC; NITRIC-OXIDE SYNTHASE;
   DIABETES-MELLITUS; SUBSTRATE UTILIZATION
AB Stress-hyperglycemia and insulin resistance are exceedingly common in critically ill patients, particularly those with sepsis. Multiple pathogenetic mechanisms are responsible for this metabolic syndrome; however, increased release of pro-inflammatory mediators and counter-regulatory hormones may play a pivotal role. Recent data suggests that hyperglycemia may potentiate the pro-inflammatory response while insulin has the opposite effect. Furthermore, emerging evidence suggests that tight glycemic control will improve the outcome of critically ill patients. This paper reviews the pathophysiology of stress hyperglycemia in the critically ill septic patient and outlines a treatment strategy for the management of this disorder.
C1 Univ Pittsburgh, Med Ctr, Dept Crit Care Med, Pittsburgh, PA 15261 USA.
   Conemaugh Mem Med Ctr, Johnstown, PA USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE); University
   of Pittsburgh
RP Univ Pittsburgh, Med Ctr, Dept Crit Care Med, 640A Scaife Hall,3550 Terrace St, Pittsburgh, PA 15261 USA.
EM maripe@ccm.upmc.edu
RI Marik, Paul/U-9733-2019
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NR 115
TC 281
Z9 322
U1 1
U2 32
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0342-4642
EI 1432-1238
J9 INTENS CARE MED
JI Intensive Care Med.
PD MAY
PY 2004
VL 30
IS 5
BP 748
EP 756
DI 10.1007/s00134-004-2167-y
PG 9
WC Critical Care Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 817BW
UT WOS:000221154000006
PM 14991101
DA 2025-06-11
ER

PT J
AU Ellison, PT
AF Ellison, Peter T.
TI Fetal Programming and Fetal Psychology
SO INFANT AND CHILD DEVELOPMENT
LA English
DT Article
DE fetal programming hypothesis; evolutionary biology
ID CONGENITAL ADRENAL-HYPERPLASIA; PREDICTIVE ADAPTIVE RESPONSE;
   CORONARY-HEART-DISEASE; METABOLIC SYNDROME; BIRTH-WEIGHT; MATERNAL-CARE;
   BREAST-CANCER; DEVELOPMENTAL PLASTICITY; INSULIN-RESISTANCE; PRENATAL
   STRESS
AB The introduction of the 'fetal programming hypothesis', first in epidemiology, subsequently in a broad range of disciplines concerned with developmental biology, has generated new interest in phenotypic plasticity, the mechanisms that govern it, and its place in evolutionary biology. A number of epidemiological studies link small size at birth, assumed to be a consequence of constrained prenatal energy availability, with adverse effects on the risk of chronic diseases later in life. The cluster of chronic diseases associated with the metabolic syndrome and alterations of glucose metabolism are particularly implicated. Recent evidence suggests that epigenetic modification of gene expression affecting the hypothalamic-pituitary-adrenal (HPA) axis may be involved in these effects. In animal studies epigenetic alteration of HPA axis activity and responsiveness is associated with changes in adult behaviour and stress responsiveness. The potential for similar effects to contribute to psychological and psychiatric outcomes in humans has been explored in a number of contexts, including famine exposure, observed covariance with birth weight, and prenatal dexamethasone treatment of fetuses at risk of congenital adrenal hyperplasia. While fetal programming effects have now been widely demonstrated across species and human populations, the adaptive significance of these effects is still a matter of debate. Copyright (C) 2010 John Wiley & Sons, Ltd.
C1 Harvard Univ, Dept Human Evolutionary Biol, Peabody Museum, Cambridge, MA 02138 USA.
C3 Harvard University
RP Ellison, PT (corresponding author), Harvard Univ, Dept Human Evolutionary Biol, Peabody Museum, Cambridge, MA 02138 USA.
EM pellison@fas.harvard.edu
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NR 108
TC 16
Z9 23
U1 0
U2 18
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1522-7227
EI 1522-7219
J9 INFANT CHILD DEV
JI Infant Child Dev.
PD JAN-FEB
PY 2010
VL 19
IS 1
SI SI
BP 6
EP 20
DI 10.1002/icd.649
PG 15
WC Psychology, Developmental
WE Social Science Citation Index (SSCI)
SC Psychology
GA 562SN
UT WOS:000275075100002
OA Green Submitted, Bronze
DA 2025-06-11
ER

PT J
AU Nader, N
   Chrousos, GP
   Kino, T
AF Nader, Nancy
   Chrousos, George P.
   Kino, Tomoshige
TI Interactions of the circadian CLOCK system and the HPA axis
SO TRENDS IN ENDOCRINOLOGY AND METABOLISM
LA English
DT Review
ID REV-ERB-ALPHA; METABOLIC SYNDROME; PERIPHERAL-TISSUES; GENE-EXPRESSION;
   TRANSCRIPTION FACTOR; STRIA TERMINALIS; CENTRAL NUCLEUS; ADRENAL-GLAND;
   OVAL NUCLEUS; SHIFT WORK
AB Organisms have developed concurrent behavioral and physiological adaptations to the strong influence of day/night cycles, as well as to unforeseen, random stress stimuli. These circadian and stress-related responses are achieved by two highly conserved and interrelated regulatory networks, the circadian CLOCK and stress systems, which respectively consist of oscillating molecular pacemakers, the Clock/Bmal1 transcription factors, and the hypothalamic-pituitary-adrenal (HPA) axis and its end-effector, the glucocorticoid receptor. These systems communicate with one another at different signaling levels and dysregulation of either system can lead to development of pathologic conditions. In this review, we summarize the mutual physiologic interactions between the circadian CLOCK system and the HPA axis, and discuss their clinical implications.
C1 [Nader, Nancy; Kino, Tomoshige] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Unit Mol Hormone Act, Program Reprod & Adult Endocrinol, NIH, Bethesda, MD 20892 USA.
   [Chrousos, George P.] Univ Athens, Sch Med, Dept Pediat 1, GR-11527 Athens, Greece.
C3 National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver
   National Institute of Child Health & Human Development (NICHD); Athens
   Medical School; National & Kapodistrian University of Athens
RP Kino, T (corresponding author), Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Unit Mol Hormone Act, Program Reprod & Adult Endocrinol, NIH, Bethesda, MD 20892 USA.
EM kinot@mail.nih.gov
RI Chrousos, George/G-8702-2011; Nader, Nader/E-6358-2014
OI Nader, Nader/0000-0002-5744-7319
FU Eunice Kennedy Shriver National Institute of Child Health and Human
   Development, National Institutes of Health, Bethesda, MD
FX Literary work of this article was funded partly by the Intramural
   Research Program of the Eunice Kennedy Shriver National Institute of
   Child Health and Human Development, National Institutes of Health,
   Bethesda, MD.
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NR 64
TC 311
Z9 352
U1 1
U2 45
PU ELSEVIER SCIENCE LONDON
PI LONDON
PA 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND
SN 1043-2760
EI 1879-3061
J9 TRENDS ENDOCRIN MET
JI Trends Endocrinol. Metab.
PD MAY
PY 2010
VL 21
IS 5
BP 277
EP 286
DI 10.1016/j.tem.2009.12.011
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 609RK
UT WOS:000278674600003
PM 20106676
OA Green Accepted, Green Submitted
DA 2025-06-11
ER

PT J
AU Jaeschke, A
   Davis, RJ
AF Jaeschke, Anja
   Davis, Roger J.
TI Metabolic stress signaling mediated by mixed-lineage kinases
SO MOLECULAR CELL
LA English
DT Article
ID INDUCED INSULIN-RESISTANCE; FREE FATTY-ACIDS; RECEPTOR SUBSTRATE-1;
   TRANSDUCTION PATHWAY; MUSCLE-CELLS; MAP KINASES; IN-VIVO; B-RAF; JNK;
   ACTIVATION
AB Saturated free fatty acid (FFA) is a major source of metabolic stress that activates the c-Jun NH2-terminal kinase (JINK). This FFA-stimulated JNK pathway is relevant to hallmarks of metabolic syndrome, including insulin resistance. Here we used gene ablation studies in mice to demonstrate a central role for mixed-lineage protein kinases (MLK) in this signaling pathway. Saturated FFA causes protein kinase C (PKC)dependent activation of MLK3 that subsequently causes increased JNK activity by a mechanism that requires the MAP kinase kinases MKK4 and MKK7. Loss of PKC, MLK3, MKK4, or MKK7 expression prevents FIFA-stimulated JNK activation. Together, these data establish a signaling pathway that mediates effects of metabolic stress on insulin resistance.
C1 Univ Massachusetts, Sch Med, Howard Hughes Med Inst, Worcester, MA 01605 USA.
   Univ Massachusetts, Sch Med, Program Mol Med, Worcester, MA 01605 USA.
C3 Howard Hughes Medical Institute; University of Massachusetts System;
   University of Massachusetts Worcester; University of Massachusetts
   System; University of Massachusetts Worcester
RP Davis, RJ (corresponding author), Univ Massachusetts, Sch Med, Howard Hughes Med Inst, Worcester, MA 01605 USA.
EM roger.davis@umassmed.edu
OI Davis, Roger/0000-0002-0130-1652
FU NCI NIH HHS [R01 CA065861] Funding Source: Medline; NIDDK NIH HHS [R01
   DK063368] Funding Source: Medline
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NR 59
TC 116
Z9 126
U1 0
U2 4
PU CELL PRESS
PI CAMBRIDGE
PA 1100 MASSACHUSETTS AVE, CAMBRIDGE, MA 02138 USA
SN 1097-2765
J9 MOL CELL
JI Mol. Cell
PD AUG 3
PY 2007
VL 27
IS 3
BP 498
EP 508
DI 10.1016/j.molcel.2007.07.008
PG 11
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA 201HZ
UT WOS:000248823400013
PM 17679097
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Elovainio, M
   Kivimäki, M
   Viikari, J
   Raitakari, OT
   Keltikangas-Järvinen, L
   Pulkki-Råback, L
   Jokela, M
   Telama, R
AF Elovainio, Marko
   Kivimaki, Mika
   Viikari, Jorma
   Raitakari, Olli T.
   Keltikangas-Jarvinen, Liisa
   Pulkki-Raback, Laura
   Jokela, Markus
   Telama, Risto
TI Lipid Trajectories as Predictors of Depressive Symptoms: The Young Finns
   Study
SO HEALTH PSYCHOLOGY
LA English
DT Article
DE depression; CHD; psychosocial factors; lipids
ID LOW SERUM-CHOLESTEROL; LATE-LIFE DEPRESSION; LOW HDL CHOLESTEROL;
   C-REACTIVE PROTEIN; MAJOR DEPRESSION; CARDIOVASCULAR RISK; METABOLIC
   SYNDROME; ASSOCIATION; CHILDHOOD; HYPOCHOLESTEROLEMIA
AB Objective: The aim of this study was to identify common trajectories of lipid levels across childhood and early adulthood life span. Design: The sample was a subpopulation of 824 young adults (3 to 9 years of age at baseline in 1980) of the ongoing population-based prospective Cardiovascular Risk in Young Finns Study. Lipid levels were determined in 1980, 1983, 1986, and 2001. Main Outcome Measures: Depressive symptoms were assessed using a modified version of Beck's Depression Inventory (Beck, 1967) in 1992 and 2001. Results: The 2 triglycerides trajectories (steeply vs. moderately increasing) were differently related to depressive symptoms in adulthood. The trajectory showing steep increase over time was associated with higher level of depressive symptoms (M 2.18, 95% Cl [2.08, 2.28] vs. 1.99, [1.95, 2.04]). This relationship persisted after adjustments for various risk factors. These triglycerides trajectories accounted for part of the association between high body mass index and depressive symptoms. Conclusion: A pattern of steeply increasing triglyceride levels throughout childhood and adulthood may be associated with increased the risk of depressive symptoms in adulthood. This pattern may also be one link between obesity and depressive symptoms.
C1 [Elovainio, Marko] Natl Inst Hlth & Welf, Helsinki 00271, Finland.
   [Elovainio, Marko; Keltikangas-Jarvinen, Liisa; Pulkki-Raback, Laura; Jokela, Markus] Univ Helsinki, Dept Psychol, FIN-00014 Helsinki, Finland.
   [Kivimaki, Mika] Univ Coll London, Dept Epidemiol & Publ Hlth, Helsinki, Finland.
   [Kivimaki, Mika] Finnish Inst Occupat Hlth, Helsinki, Finland.
   [Viikari, Jorma; Raitakari, Olli T.; Keltikangas-Jarvinen, Liisa] Univ Turku, Res Ctr Appl & Prevent Cardiovasc Med, SF-20500 Turku, Finland.
   [Viikari, Jorma; Raitakari, Olli T.] Univ Turku, Dept Clin Physiol, SF-20500 Turku, Finland.
   [Telama, Risto] Univ Jyvaskyla, LIKES, SF-40351 Jyvaskyla, Finland.
C3 Finland National Institute for Health & Welfare; University of Helsinki;
   Finnish Institute of Occupational Health; University of Turku;
   University of Turku; University of Jyvaskyla
RP Elovainio, M (corresponding author), Natl Inst Hlth & Welf, POB 30, Helsinki 00271, Finland.
EM marko.elovainio@thl.fi
RI Kivimaki, Mika/B-3607-2012; Raitakari, Olli/AAQ-7389-2021; Jokela,
   Markus/A-4669-2009
OI Elovainio, Marko/0000-0002-1401-1910; Kivimaki,
   Mika/0000-0002-4699-5627; Jokela, Markus/0000-0003-0117-0012
FU Signe and Ane Gyllenberg's Foundation; Academy of Finland [111056,
   209514, 123399, 123621, 117604, 7784, 210283, 128002]; Emil Aaltonen
   Foundation; Tampere University Hospital Medical Fund; Yrjo Jahnsson
   Foundation and Turku University; National Heart, Lung, and Blood
   Institute [R01HL036310-20A2]; National Institute on Aging
   [R01AG034454-01]; U.S. National Institutes of Health; Academy of
   Finland; BUPA Foundation, United Kingdom
FX This study was financially supported by the Signe and Ane Gyllenberg's
   Foundation (Liisa Keltikangas-Jarvinen), the Academy of Finland Grants
   111056, 209514, 123399 (Liisa Keltikangas-Jarvinen), 123621 (Laura
   Pulkki-Raback) and 117604 (Mika Kivimaki) and 7784 and 210283 (Olli T.
   Raitakari), Emil Aaltonen Foundation (Risto Telma), Tampere University
   Hospital Medical Fund (Risto Telma), the Yrjo Jahnsson Foundation and
   Turku University Hospital Medical Funds (Olli T. Raitakari and Jorma
   Viikari). Marko Elovainio was supported by the Work Environment Fund and
   Academy of Finland (128002). Mika Kivimaki was supported by the National
   Heart, Lung, and Blood Institute (R01HL036310-20A2) and the National
   Institute on Aging (R01AG034454-01) of the U.S. National Institutes of
   Health; by the Academy of Finland; and by the BUPA Foundation, United
   Kingdom.
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NR 49
TC 24
Z9 24
U1 0
U2 9
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 0278-6133
EI 1930-7810
J9 HEALTH PSYCHOL
JI Health Psychol.
PD MAY
PY 2010
VL 29
IS 3
BP 237
EP 245
DI 10.1037/a0018875
PG 9
WC Psychology, Clinical; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology
GA 604TS
UT WOS:000278302000001
PM 20496976
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Iraj, B
   Taheri, N
   Amini, M
   Amini, P
   Aminorroaya, A
AF Iraj, Bijan
   Taheri, Nader
   Amini, Massoud
   Amini, Payvand
   Aminorroaya, Ashraf
TI Should the first degree relatives of type 2 diabetic patients with
   isolated impaired fasting glucose be considered for a diabetes primary
   prevention program?
SO JOURNAL OF RESEARCH IN MEDICAL SCIENCES
LA English
DT Article
DE Prediabetic States Diabetes Mellitus; Type II; Oral Glucose Tolerance
   Test; Primary Prevention; Dyslipidemia; Risk Factor; Iran
ID OXIDATIVE STRESS; GLUTATHIONE-PEROXIDASE; SUPEROXIDE-DISMUTASE;
   ANTIOXIDANT ENZYMES; BY-PRODUCTS; HYPERTENSION; CATALASE; AGE;
   EXPRESSION; DISEASE
AB BACKGROUND The aim of this study is to investigate the need for diabetes primary prevention program in isolated impaired fasting glucose (i-IFG) of the first degree relatives of type 2 diabetics
   METHODS In a cross sectional study, 793 individuals with prediabetes [543 with i-IFG and 250 with isolated impaired glucose tolerance (i-IGT)] who were the first degree relatives of type 2 diabetic patients were enrolled Isolated IFG was considered as fasting plasma glucose between 100-125 mg/dl and 2 hour plasma glucose < 140 mg/dl and isolated JOT as FPG < 100 mg/dl and 2 hour plasma glucose between 140-199 mg/dl during an overnight fasting 75 g oral glucose tolerance test Mean of the age, weight, waist circumference, body mass index systolic and diastolic blood pressure, plasma glucose, HbA1C, and lipid profile were compared between two groups (i-IFG and i-IGT) The prevalence of cardiometabolic risk factors (BMI >= 25 kg/m2 hypertension cholesterol >= 200 mg/dl LDL-C >= 100 mg/dl HDL-C <= 40 mg/dl, and triglyceride >= 150 mg/dl) adjusted by age, sex and BMI were compared
   RESULTS The prevalence of cardiometabolic risk factors is higher in i-IFG group than i-IGT The mean level of LDL-C is significantly higher in i-IFG than i-IGT group
   CONCLUSIONS First degree relatives of T2DM with isolated impaired fasting glucose should probably be included in the primary preventive program for diabetes However, longitudinal cohort study is required to show high progression of i-IFG to T2DM
C1 [Iraj, Bijan; Taheri, Nader; Amini, Massoud; Amini, Payvand; Aminorroaya, Ashraf] Isfahan Univ Med Sci, Isfahan Endocrine & Metab Res Ctr, Esfahan, Iran.
C3 Isfahan University of Medical Sciences
RP Aminorroaya, A (corresponding author), Isfahan Univ Med Sci, Isfahan Endocrine & Metab Res Ctr, Esfahan, Iran.
RI Janghorbani, Mohsen/A-2330-2010; Amini, Massoud/C-5340-2013;
   Aminorroaya, Ashraf/B-9240-2013; iraj, bijan/E-6662-2012
OI Aminorroaya, Ashraf/0000-0002-7550-1198; Amini,
   Massoud/0000-0003-4134-0960; iraj, bijan/0000-0003-0561-408X
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NR 31
TC 7
Z9 8
U1 0
U2 1
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, Maharashtra, INDIA
SN 1735-1995
EI 1735-7136
J9 J RES MED SCI
JI J. Res. Med. Sci.
PD SEP-OCT
PY 2010
VL 15
IS 5
BP 264
EP 278
PG 15
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 688QQ
UT WOS:000284866900004
PM 21526094
DA 2025-06-11
ER

PT J
AU Shrestha, S
   Irvin, MR
   Grunfeld, C
   Arnett, DK
AF Shrestha, Sadeep
   Irvin, Marguerite R.
   Grunfeld, Carl
   Arnett, Donna K.
TI HIV, Inflammation, and Calcium in Atherosclerosis
SO ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
LA English
DT Review
DE atherosclerosis; calcium; endoplasmic reticulum stress; HIV;
   inflammation
ID TOLL-LIKE RECEPTORS; ENDOPLASMIC-RETICULUM STRESS; CARDIOVASCULAR
   RISK-FACTORS; REGIONAL ADIPOSE-TISSUE; CORONARY-HEART-DISEASE;
   ANTIRETROVIRAL THERAPY; PROTEASE INHIBITORS; ADHESION MOLECULES;
   LIPOPROTEIN LEVELS; METABOLIC SYNDROME
AB Atherosclerosis is consistently higher among the HIV-positive patients, with or without treatment, than among the HIV-negative population. Risk factors linked to atherosclerotic cardiovascular disease in HIV infection are both traditional and HIV specific although the underlying mechanisms are not fully delineated. Three key sequential biological processes are postulated to accelerate progression of atherosclerosis in the context of HIV: (1) inflammation, (2) transformation of monocytes to macrophages and then foam cells, and (3) apoptosis of foam cells leading to plaque development through Ca2+-dependent endoplasmic reticulum stress. These proatherogenic mechanisms are further affected when HIV interacts with the genes involved in various phases within this network.
C1 [Shrestha, Sadeep; Irvin, Marguerite R.; Arnett, Donna K.] Univ Alabama Birmingham, Dept Epidemiol, Sch Publ Hlth, Birmingham, AL 35294 USA.
   [Grunfeld, Carl] Univ Calif San Francisco, Div Endocrinol & Metab, San Francisco, CA 94143 USA.
   [Grunfeld, Carl] Vet Affairs Med Ctr, San Francisco, CA 94121 USA.
C3 University of Alabama System; University of Alabama Birmingham;
   University of California System; University of California San Francisco;
   US Department of Veterans Affairs; Veterans Health Administration (VHA)
RP Shrestha, S (corresponding author), Univ Alabama Birmingham, Dept Epidemiol, 1665 Univ Blvd,RPHB Room 217L, Birmingham, AL 35294 USA.
EM sshrestha@uab.edu
OI Arnett, Donna/0000-0003-2219-657X
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NR 100
TC 52
Z9 59
U1 0
U2 9
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1079-5642
EI 1524-4636
J9 ARTERIOSCL THROM VAS
JI Arterioscler. Thromb. Vasc. Biol.
PD FEB
PY 2014
VL 34
IS 2
BP 244
EP 250
DI 10.1161/ATVBAHA.113.302191
PG 7
WC Hematology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Hematology; Cardiovascular System & Cardiology
GA AG7OL
UT WOS:000335607300008
PM 24265418
OA Bronze
DA 2025-06-11
ER

PT J
AU Sparic, R
   Andjic, M
   Vergara, D
   Morciano, A
   D'Oria, O
   Baldini, GM
   Malvasi, A
   Tinelli, A
AF Sparic, Radmila
   Andjic, Mladen
   Vergara, Daniele
   Morciano, Andrea
   D'Oria, Ottavia
   Baldini, Giorgio Maria
   Malvasi, Antonio
   Tinelli, Andrea
TI PCOS and vitamin D: a clinical appraisal
SO ARCHIVES OF GYNECOLOGY AND OBSTETRICS
LA English
DT Review
DE PCOS; Vitamin D; Metabolic syndrome; Endocrine disorders; Insulin
   resistance
AB PurposePolycystic ovary syndrome (PCOS) is the most common endocrine-reproductive disease linked not just to infertility but also to serious comorbidities. There is a reported association between low vitamin D levels and multiple health conditions including PCOS. This narrative review aims to analyze the role of vitamin D in PCOS development, use of the vitamin D in the treatment of PCOS, and the molecular basis of these observations.MethodsA Medline and PubMed research was performed, during the years 1990-2023, using a combination of keywords on such topic. According to the author's evaluation and target, papers were identified and included for a narrative review.ResultsThere are associations between lower levels of vitamin D and PCOS, as well as with insulin resistance, metabolic syndrome, hyperandrogenemia, metabolic and endocrine disorders as well as the onset of oxidative stress and pro-inflammatory milieu, in PCOS women.ConclusionVitamin D has a role in pathologic changes linked to PCOS. Molecular and clinical investigations which give new information about the role of vitamin D in the development of PCOS and related endocrine and metabolic disturbance are further needed.
C1 [Sparic, Radmila; Andjic, Mladen] Univ Clin Ctr Serbia, Clin Gynecol & Obstet, Belgrade 11000, Serbia.
   [Sparic, Radmila] Univ Belgrade, Fac Med, Belgrade 11000, Serbia.
   [Vergara, Daniele] Univ Salento, Dept Biol & Environm Sci & Technol DiSTeBA, Str Prov Lecce Monteroni, I-73100 Lecce, Italy.
   [Morciano, Andrea] Pia Fdn Card G Panico, Dept Gynecol & Obstet, Lecce, Italy.
   [D'Oria, Ottavia] Dept Med & Surg Sci & Translat Med, Translat Med & Oncol, Rome, Italy.
   [D'Oria, Ottavia] Sapienza Univ, Dept Gynecol Obstetr & Urol Sci, Rome, Italy.
   [Baldini, Giorgio Maria] MOMO Ferti LIFE IVF Ctr, Bisceglie, Italy.
   [Malvasi, Antonio] Univ Bari, Dept Biomed Sci & Human Oncol, I-70121 Bari, Italy.
   [Tinelli, Andrea] Veris delli Ponti Hosp, Dept Obstet & Gynecol, Via Giuseppina delli Ponti, I-73020 Lecce, Italy.
   [Tinelli, Andrea] Veris delli Ponti Hosp, CERICSAL Ctr Ric Clin SALentino, Via Giuseppina delli Ponti, I-73020 Lecce, Italy.
C3 Clinical Centre of Serbia; University of Belgrade; University of
   Salento; Sapienza University Rome; Universita degli Studi di Bari Aldo
   Moro
RP Tinelli, A (corresponding author), Veris delli Ponti Hosp, Dept Obstet & Gynecol, Via Giuseppina delli Ponti, I-73020 Lecce, Italy.; Tinelli, A (corresponding author), Veris delli Ponti Hosp, CERICSAL Ctr Ric Clin SALentino, Via Giuseppina delli Ponti, I-73020 Lecce, Italy.
EM andreatinelli@gmail.com
RI D'Oria, Ottavia/HJY-0040-2023; Morciano, Andrea/GPS-9104-2022; Vergara,
   Daniele/K-3831-2014; Tinelli, Andrea/B-6811-2014
OI Vergara, Daniele/0000-0002-2396-7674; Morciano,
   Andrea/0000-0001-5420-4277; Tinelli, Andrea/0000-0001-8426-8490;
   Malvasi, Antonio/0000-0001-6940-7608; Andic, Mladen/0000-0002-6312-5404;
   Baldini, Giorgio Maria/0000-0002-5061-8007; D'Oria,
   Ottavia/0000-0002-3482-1523
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NR 66
TC 1
Z9 1
U1 1
U2 6
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0932-0067
EI 1432-0711
J9 ARCH GYNECOL OBSTET
JI Arch. Gynecol. Obstet.
PD MAR
PY 2024
VL 309
IS 3
BP 907
EP 915
DI 10.1007/s00404-023-07227-x
EA SEP 2023
PG 9
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA HT9M2
UT WOS:001071601400001
PM 37747553
DA 2025-06-11
ER

PT J
AU Ojeda, ML
   Carreras, O
   del Valle, PM
   Murillo, ML
   Nogales, F
AF Luisa Ojeda, M.
   Carreras, Olimpia
   Munoz del Valle, Paulina
   Luisa Murillo, M.
   Nogales, Fatima
TI Fructose exposure during gestation and lactation altered hepatic
   selenoprotein expression, oxidative balance and metabolic profile in
   female rat pups
SO JOURNAL OF FUNCTIONAL FOODS
LA English
DT Article
DE Metabolic syndrome; Selenoprotein; Early nutrition; High fructose diet
ID GLUTATHIONE PEROXIDASES; INSULIN-RESISTANCE; ADULT MALE; SELENIUM;
   PREGNANCY; STRESS; DAMAGE; LIVER; GENE; HEPATOCYTES
AB Fructose-rich diets, an experimental model of induced metabolic syndrome (MS), affects pregnant and lactating rat dams, and moreover, it leads to an imbalance in their offspring's metabolic profile. Selenium (Se) homeostasis and body distribution is also altered. Selenoproteins: Glutathione peroxidase (GPx) and selenoprotein P (SelP) appear to play a role in MS. To evaluate selenoproteins' implication in the transmission of this pathology to the progeny, hepatic Se deposits, GPx activity, biomolecular oxidation and selenoproteins and AMPK expression were measured in the offspring of dams exposed to a fructose-rich diet (65%). Se intake and liver selenoproteins are affected by fructose exposition during early nutrition. Female fructose pups show a repletion of Se and oxidation in liver, higher GPx activity and expression of hepatic GPx1 and Se1P, related to a lower activation of AMPK and serum insulin levels. Fructose exposure during early nutrition negatively alters selenoproteins, oxidation and metabolism in female pups.
C1 [Luisa Ojeda, M.; Carreras, Olimpia; Munoz del Valle, Paulina; Luisa Murillo, M.; Nogales, Fatima] Univ Seville, Fac Pharm, Dept Physiol, C Prof Garcia Gonzalez 2, E-41012 Seville, Spain.
C3 University of Sevilla
RP Nogales, F (corresponding author), Univ Seville, Fac Pharm, Dept Physiol, C Prof Garcia Gonzalez 2, E-41012 Seville, Spain.
EM fnogales@us.es
RI Ojeda, Luisa/B-8571-2019; Carreras, olimpia/P-9078-2019; Nogales,
   F/B-8562-2019
OI Maria Luisa, Ojeda Murillo/0000-0002-9160-2749; Nogales,
   Fatima/0000-0003-4844-2740; Carreras, Olimpia/0000-0002-3858-0165
FU Andalusian Regional Government [CTS-193]
FX This work was supported by the Andalusian Regional Government (Support
   to CTS-193 research group).
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NR 43
TC 5
Z9 5
U1 0
U2 4
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1756-4646
J9 J FUNCT FOODS
JI J. Funct. Food.
PD APR
PY 2018
VL 43
BP 77
EP 83
DI 10.1016/j.jff.2018.01.026
PG 7
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA GC4MG
UT WOS:000429758000010
DA 2025-06-11
ER

PT J
AU Cignarelli, M
   Lamacchia, O
AF Cignarelli, Mauro
   Lamacchia, Olga
TI Obesity and kidney disease
SO NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
LA English
DT Review
DE obesity; kidney; metabolic syndrome; remodeling; oxidative stress
ID BODY-MASS INDEX; FOCAL SEGMENTAL GLOMERULOSCLEROSIS; MEDIATED GLOMERULAR
   INJURY; INDEPENDENT RISK-FACTOR; WEIGHT-LOSS; METABOLIC SYNDROME;
   OVERWEIGHT PATIENTS; PROGRESSIVE NATURE; DIABETES-MELLITUS;
   BLOOD-PRESSURE
AB The prevalence of obesity worldwide has increased dramatically. Besides, an approximately two-fold higher rate of increase in mean BMI among the incident ESRD has been reported in the US population from 1995-2002. Chronic kidney disease (CKD) prevalence increases from 2.9% among adults with an ideal BMI to 4.5% among obese adults. The development of CKD is usually the culminating result of the interaction of multiple risk factors. Obesity represents one example of a multitoxicity state and given the background of genetic susceptibility and/or reduced nephron number, overweight may initiate renal remodeling and/or accelerate kidney failure. Obesity may be the number one preventable risk factor for CKD. Weight toss has indeed been shown to improve glomerular hemodynamics and reduce urine albumin excretion. Thus, obese patients with CKD should be counseled on the benefits of weight toss. (c) 2007 Elsevier B.V. All rights reserved.
C1 [Cignarelli, Mauro; Lamacchia, Olga] Univ Foggia, Dept Med Sci, Unit Endocrinol & Metab Dis, I-71100 Foggia, Italy.
C3 University of Foggia
RP Cignarelli, M (corresponding author), Univ Foggia, Dept Med Sci, Unit Endocrinol & Metab Dis, Via Luigi Pinto 1, I-71100 Foggia, Italy.
EM m.cignarelli@unifg.it
RI Lamacchia, Olga/AEY-9588-2022
OI Lamacchia, Olga/0000-0002-9175-489X
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TC 53
Z9 60
U1 0
U2 5
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0939-4753
EI 1590-3729
J9 NUTR METAB CARDIOVAS
JI Nutr. Metab. Carbiovasc. Dis.
PD DEC
PY 2007
VL 17
IS 10
BP 757
EP 762
DI 10.1016/j.numecd.2007.03.003
PG 6
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism; Nutrition
   & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism;
   Nutrition & Dietetics
GA 252QI
UT WOS:000252460900009
PM 17606365
DA 2025-06-11
ER

PT J
AU Lang, F
   Gawaz, M
   Borst, O
AF Lang, F.
   Gawaz, M.
   Borst, O.
TI The serum- & glucocorticoid-inducible kinase in the regulation of
   platelet function
SO ACTA PHYSIOLOGICA
LA English
DT Review
DE Ca2+; metabolic syndrome; Orai1; platelets; SGK1; thrombus formation
ID CA2+ CHANNEL ORAI1; PATHOGENIC T(H)17 CELLS; THROMBUS FORMATION;
   KAPPA-B; PROCOAGULANT RESPONSE; CALCIUM-CONCENTRATION; ARTERIAL
   THROMBOSIS; DIABETES-MELLITUS; TISSUE FACTOR; UP-REGULATION
AB The serum- and glucocorticoid-inducible kinase 1 (SGK1) is expressed in megakaryocytes and circulating platelets. In megakaryocytes, SGK1 activates transcription factor nuclear factor kappa-B (NF-B), which in turn stimulates expression of Orai1, a Ca2+ channel protein accomplishing store-operated Ca2+ enrty (SOCE). SGK1 enhances SOCE and several Ca2+-sensitive platelet functions, including degranulation, integrin (IIb3) activation, phosphatidylserine exposure, aggregation and thrombus formation. As shown in other cell types, stimulators of SGK1 expression include ischaemia, oxidative stress, hyperglycaemia, advanced glycation end products (AGEs) and a variety of hormones such as glucocorticoids, mineralocorticoids, transforming growth factor beta (TGF), interleukin 6 (IL-6), platelet-derived growth factor (PDGF), thrombin and endothelin. Thus, SGK1-sensitive Ca2+ signalling may contribute to altered platelet function in several clinical conditions including inflammation, metabolic syndrome, diabetes mellitus and chronic renal failure. Nevertheless, further studies are needed defining the contribution of altered SGK1 expression and activity to physiology and pathophysiology of platelets.
C1 [Lang, F.; Borst, O.] Univ Tubingen, Dept Physiol, Gmelinstr 5, D-72076 Tubingen, Germany.
   [Gawaz, M.; Borst, O.] Univ Tubingen, Dept Cardiol & Cardiovasc Med, D-72076 Tubingen, Germany.
C3 Eberhard Karls University of Tubingen; Eberhard Karls University of
   Tubingen
RP Lang, F (corresponding author), Univ Tubingen, Dept Physiol, Gmelinstr 5, D-72076 Tubingen, Germany.
EM florian.lang@uni-tuebingen.de
OI Borst, Oliver/0000-0003-4002-4085
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NR 96
TC 19
Z9 21
U1 0
U2 11
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1748-1708
EI 1748-1716
J9 ACTA PHYSIOL
JI Acta Physiol.
PD JAN
PY 2015
VL 213
IS 1
BP 181
EP 190
DI 10.1111/apha.12334
PG 10
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA AW7XN
UT WOS:000346475000013
PM 24947805
DA 2025-06-11
ER

PT J
AU Norberto, S
   Silva, S
   Meireles, M
   Faria, A
   Pintado, M
   Calhau, C
AF Norberto, Sonia
   Silva, Sara
   Meireles, Manuela
   Faria, Ana
   Pintado, Manuela
   Calhau, Conceicao
TI Blueberry anthocyanins in health promotion: A metabolic overview
SO JOURNAL OF FUNCTIONAL FOODS
LA English
DT Review
DE Anthocyanin; Bioavailability; Blueberry; Metabolic syndrome; Obesity
ID BILBERRY VACCINIUM-MYRTILLUS; ANTIOXIDANT ACTIVITY; PHENOLIC-COMPOUNDS;
   CYANIDIN 3-O-BETA-D-GLUCOSIDE; BERRY ANTHOCYANINS; INTESTINAL UPTAKE;
   OXIDATIVE STRESS; GENE-EXPRESSION; WHOLE BERRIES; ELDERLY WOMEN
AB Diet has gained scientific community attention due to the crucial role in health maintenance, but also in disease treatment, and essential in disease prevention. Several food and food components, particularly phenolic rich foods, have been investigated as they present themselves as putative functional foods. In the past decades, obesity has reached epidemic proportions and consequently, metabolic syndrome (a set of disorders as impaired glucose tolerance, insulin resistance, abdominal obesity, dyslipidemia and high blood pressure, which increase the risk of cardiovascular disease and diabetes) incidence is increasing worldwide at an alarming rate and this phenolic rich foods, specially berries have been investigated to their potential beneficial effect in this disorders.
   In the present work the chemistry of blueberries (BB) (fruits of some Vaccinium species) was summarised as well as the knowledge about bioavailability and biokinetic of anthocyanins from blueberries with particular emphasis on its implications in metabolic disorders. (C) 2013 Elsevier Ltd. All rights reserved.
C1 [Norberto, Sonia; Meireles, Manuela; Faria, Ana; Calhau, Conceicao] Univ Porto, Fac Med, Dept Biochem, P-4200319 Porto, Portugal.
   [Silva, Sara; Pintado, Manuela] Univ Catolica Portuguesa, CBQF Escola Super Biotecnol, Porto, Portugal.
   [Faria, Ana] Univ Porto, Fac Sci, Chem Invest Ctr CIQ, P-4200319 Porto, Portugal.
   [Faria, Ana] Univ Porto, Fac Nutr & Food Sci, P-4200319 Porto, Portugal.
   [Calhau, Conceicao] CINTESIS Ctr Invest Tecnol & Sistemas Informacao, Porto, Portugal.
C3 Universidade do Porto; Universidade Catolica Portuguesa; Universidade do
   Porto; Universidade do Porto
RP Calhau, C (corresponding author), Univ Porto, Fac Med, Dept Biochem, P-4200319 Porto, Portugal.
EM ccalhau@med.up.pt
RI Silva, Sara/GXM-8709-2022; Faria, Ana/A-5176-2013; Meireles,
   Manuela/L-2472-2018; Pintado, Maria Manuela/AAW-6709-2021; Calhau,
   Conceição/L-8041-2013; Pintado, Maria Manuela/F-5696-2013
OI Silva, Sara/0000-0001-8268-2137; Silva, Sara/0000-0002-0896-9946;
   Pintado, Maria Manuela/0000-0002-0760-3184; Norberto,
   Sonia/0000-0002-5388-3682; Meireles, Manuela/0000-0003-3703-0011; Faria,
   Ana/0000-0002-5165-9513; Calhau, Conceicao/0000-0001-9567-3379
FU Fundacao para a Ciencia e Tecnologia (FCT) - Fundo Social Europeu,
   Programa Operacional Potencial Humano da EU (POPH) [SFRH/BPD/75294/2010,
   SFRH/BD/78367/2011, SFRH/BD/90867/2012]; QREN - SI I&DT: MYRTILLUS -
   Mirtilos corn inovacao [13736]; Fundação para a Ciência e a Tecnologia
   [SFRH/BD/78367/2011, SFRH/BD/90867/2012] Funding Source: FCT
FX Financial support from Fundacao para a Ciencia e Tecnologia (FCT) -
   Fundo Social Europeu, Programa Operacional Potencial Humano da EU
   (POPH), SFRH/BPD/75294/2010, SFRH/BD/78367/2011 and SFRH/BD/90867/2012
   is gratefully acknowledged. Supported by 13736 QREN - SI I&DT: MYRTILLUS
   - Mirtilos corn inovacao.
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NR 105
TC 181
Z9 206
U1 1
U2 205
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1756-4646
EI 2214-9414
J9 J FUNCT FOODS
JI J. Funct. Food.
PD OCT
PY 2013
VL 5
IS 4
BP 1518
EP 1528
DI 10.1016/j.jff.2013.08.015
PG 11
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA AN6VS
UT WOS:000340737100002
DA 2025-06-11
ER

PT J
AU Singleton, JR
   Smith, AG
   Marcus, RL
AF Singleton, J. Robinson
   Smith, A. Gordon
   Marcus, Robin L.
TI Exercise as Therapy for Diabetic and Prediabetic Neuropathy
SO CURRENT DIABETES REPORTS
LA English
DT Review
DE Diabetic neuropathy; Exercise; Metabolic syndrome; Human trials;
   Sedentary behavior; Actigraphy
ID LIFE-STYLE INTERVENTION; ALDOSE REDUCTASE INHIBITOR; ALPHA-LIPOIC ACID;
   PERIPHERAL NEUROPATHY; METABOLIC SYNDROME; PHYSICAL-ACTIVITY; PAINFUL
   NEUROPATHY; ENERGY-EXPENDITURE; GLYCEMIC CONTROL; ACE-INHIBITOR
AB Length-dependent neuropathy is the most common and costly complication of diabetes and frequently causes injury primarily to small-diameter cutaneous nociceptive fibers. Not only persistent hyperglycemia but also metabolic, endocrine, and inflammatory effects of obesity and dyslipidemia appear to play an important role in the development of diabetic neuropathy. Rational therapies aimed at direct control of glucose or its increased entry into the polyol pathway, oxidative or nitrosative stress, advanced glycation end product formation or signaling, microvascular ischemia, or adipocyte-derived toxicity have each failed in human trials of diabetic neuropathy. Aerobic exercise produces salutary effects in many of these pathogenic pathways simultaneously and, in both animal models and human trials, has been shown to improve symptoms of neuropathy and promote re-growth of cutaneous small-diameter fibers. Behavioral reduction in periods of seated, awake inactivity produces multimodal metabolic benefits similar to exercise, and the two strategies when combined may offer sustained benefit to peripheral nerve function.
C1 [Singleton, J. Robinson; Smith, A. Gordon] Univ Utah, Dept Neurol, Salt Lake City, UT 84112 USA.
   [Marcus, Robin L.] Univ Utah, Dept Phys Therapy, Salt Lake City, UT USA.
C3 Utah System of Higher Education; University of Utah; Utah System of
   Higher Education; University of Utah
RP Singleton, JR (corresponding author), Univ Utah, Dept Neurol, Salt Lake City, UT 84112 USA.
EM rob.singleton@hsc.utah.edu
OI Marcus, Robin/0000-0003-1298-0141; , Tushar/0000-0002-8527-8719
FU NIH [NIH R01 DK064814]
FX All authors of this paper have funding from NIH that is supporting this
   work (NIH R01 DK064814).
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NR 99
TC 40
Z9 45
U1 1
U2 20
PU CURRENT MEDICINE GROUP
PI PHILADELPHIA
PA 400 MARKET STREET, STE 700, PHILADELPHIA, PA 19106 USA
SN 1534-4827
EI 1539-0829
J9 CURR DIABETES REP
JI Curr. Diabetes Rep.
PD DEC
PY 2015
VL 15
IS 12
AR 120
DI 10.1007/s11892-015-0682-6
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA CZ0OY
UT WOS:000366806700018
PM 26538074
DA 2025-06-11
ER

PT J
AU Malnick, SDH
   Alin, P
   Somin, M
   Neuman, MG
AF Malnick, Stephen D. H.
   Alin, Pavel
   Somin, Marina
   Neuman, Manuela G.
TI Fatty Liver Disease-Alcoholic and Non-Alcoholic: Similar but Different
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE alcoholic steatohepatitis; nonalcoholic steatohepatitis; cytokines;
   microbiome
ID HEDGEHOG PATHWAY ACTIVATION; NECROSIS-FACTOR-ALPHA; INSULIN-RESISTANCE;
   HEPATIC STEATOSIS; OXIDATIVE STRESS; UNITED-STATES; INTESTINAL
   PERMEABILITY; CARDIOVASCULAR-DISEASE; BACTERIAL OVERGROWTH; HISTOLOGIC
   FEATURES
AB In alcohol-induced liver disease (ALD) and in non-alcoholic fatty liver disease (NAFLD), there are abnormal accumulations of fat in the liver. This phenomenon may be related to excessive alcohol consumption, as well as the combination of alcohol consumption and medications. There is an evolution from simple steatosis to steatohepatitis, fibrosis and cirrhosis leading to hepatocellular carcinoma (HCC). Hepatic pathology is very similar regarding non-alcoholic fatty liver disease (NAFLD) and ALD. Initially, there is lipid accumulation in parenchyma and progression to lobular inflammation. The morphological changes in the liver mitochondria, perivenular and perisinusoidal fibrosis, and hepatocellular ballooning, apoptosis and necrosis and accumulation of fibrosis may lead to the development of cirrhosis and HCC. Medical history of ethanol consumption, laboratory markers of chronic ethanol intake, AST/ALT ratio on the one hand and features of the metabolic syndrome on the other hand, may help in estimating the contribution of alcohol intake and the metabolic syndrome, respectively, to liver steatosis.
C1 [Malnick, Stephen D. H.; Alin, Pavel; Somin, Marina] Affiliated Hebrew Univ, Kaplan Med Ctr, Dept Internal Med, IL-76100 Rehovot, Israel.
   [Neuman, Manuela G.] Univ Toronto, Temer Fac Med, Dept Pharmacol & Toxicol, Vitro Drug Safety & Biotechnol, M5G OA3, Toronto, ON, Canada.
C3 Hebrew University of Jerusalem; Kaplan Medical Center; University of
   Toronto
RP Malnick, SDH (corresponding author), Affiliated Hebrew Univ, Kaplan Med Ctr, Dept Internal Med, IL-76100 Rehovot, Israel.; Neuman, MG (corresponding author), Univ Toronto, Temer Fac Med, Dept Pharmacol & Toxicol, Vitro Drug Safety & Biotechnol, M5G OA3, Toronto, ON, Canada.
EM steve@stevemalnickmd.com; m_neuman@rogers.com
OI Malnick, Stephen/0000-0003-1865-8313
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NR 215
TC 40
Z9 42
U1 3
U2 20
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD DEC
PY 2022
VL 23
IS 24
AR 16226
DI 10.3390/ijms232416226
PG 25
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 7E6TN
UT WOS:000901297800001
PM 36555867
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Chiriac, S
   Stanciu, C
   Girleanu, I
   Cojocariu, C
   Sfarti, C
   Singeap, AM
   Cuciureanu, T
   Huiban, L
   Muzica, CM
   Zenovia, S
   Nastasa, R
   Trifan, A
AF Chiriac, Stefan
   Stanciu, Carol
   Girleanu, Irina
   Cojocariu, Camelia
   Sfarti, Catalin
   Singeap, Ana-Maria
   Cuciureanu, Tudor
   Huiban, Laura
   Muzica, Cristina Maria
   Zenovia, Sebastian
   Nastasa, Robert
   Trifan, Anca
TI Nonalcoholic Fatty Liver Disease and Cardiovascular Diseases: The Heart
   of the Matter
SO CANADIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
LA English
DT Review
ID GAMMA-GLUTAMYL-TRANSFERASE; INSULIN-RESISTANCE; LONG-TERM; SUBCLINICAL
   ATHEROSCLEROSIS; ADIPOSE-TISSUE; BLOOD-PRESSURE; FOLLOW-UP; ASSOCIATION;
   INCIDENT; RISK
AB Nonalcoholic fatty liver disease (NAFLD) has emerged as the most frequent cause of liver disease worldwide, comprising a plethora of conditions, ranging from steatosis to end-stage liver disease. Cardiovascular disease (CVD) has been associated with NAFLD and CVD-related events represent the main cause of death in patients with NAFLD, surpassing liver-related mortality. This association is not surprising as NAFLD has been considered a part of the metabolic syndrome and has been related to numerous CVD risk factors, namely, insulin resistance, abdominal obesity, dyslipidemia, hyperuricemia, chronic kidney disease, and type 2 diabetes. Moreover, both NAFLD and CVD present similar pathophysiological mechanisms, such as increased visceral adiposity, altered lipid metabolism, increased oxidative stress, and systemic inflammation that could explain their association. Whether NAFLD increases the risk for CVD or these diagnostic entities represent distinct manifestations of the metabolic syndrome has not yet been clarified. This review focuses on the relation between NAFLD and the spectrum of CVD, considering the pathophysiological mechanisms, risk factors, current evidence, and future directions.
C1 [Chiriac, Stefan; Girleanu, Irina; Cojocariu, Camelia; Sfarti, Catalin; Singeap, Ana-Maria; Cuciureanu, Tudor; Huiban, Laura; Muzica, Cristina Maria; Zenovia, Sebastian; Nastasa, Robert; Trifan, Anca] Grigore T Popa Univ Med & Pharm, Dept Gastroenterol, Iasi 700115, Romania.
   [Chiriac, Stefan; Stanciu, Carol; Girleanu, Irina; Cojocariu, Camelia; Sfarti, Catalin; Singeap, Ana-Maria; Trifan, Anca] St Spiridon Emergency Hosp, Inst Gastroenterol & Hepatol, Iasi 700111, Romania.
C3 Grigore T Popa University of Medicine & Pharmacy; Grigore T Popa
   University of Medicine & Pharmacy
RP Girleanu, I (corresponding author), Grigore T Popa Univ Med & Pharm, Dept Gastroenterol, Iasi 700115, Romania.; Girleanu, I (corresponding author), St Spiridon Emergency Hosp, Inst Gastroenterol & Hepatol, Iasi 700111, Romania.
EM stefannchiriac@yahoo.com; stanciucarol@yahoo.com; gilda_iri25@yahoo.com;
   cameliacojocariu@yahoo.com; cvsfarti@gmail.com;
   anamaria.singeap@yahoo.com; drcuciureanutudor@gmail.com;
   huiban.laura@yahoo.com; lungu.christina@yahoo.com;
   sebastianzenovia20@gmail.com; nastasa.robert@yahoo.com;
   ancatrifan@yahoo.com
RI Girleanu, Irina/MTF-8711-2025; Muzica, Cristina/AAF-6801-2019;
   Sebastian, Zenovia/AAS-7256-2020; Cuciureanu, Tudor/MTF-6908-2025;
   Chiriac, Stefan/MTF-7600-2025; Trifan, Anca/MTF-7993-2025; Nastasa,
   Robert/AAR-6930-2021
OI Cojocariu, Camelia/0000-0001-6395-335X; Sebastian,
   Zenovia/0000-0003-0441-3980; Girleanu, Irina/0000-0001-5925-1232;
   Nastasa, Robert/0000-0002-8678-0663; Cristina-Maria,
   Muzica/0000-0003-0891-5961; Cuciureanu, Tudor/0000-0003-1550-8870;
   Trifan, Anca/0000-0001-9144-5520; Singeap,
   Ana-Maria/0000-0001-5621-548X; Chiriac, Stefan/0000-0003-2497-9236
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NR 111
TC 26
Z9 26
U1 0
U2 13
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2291-2789
EI 2291-2797
J9 CAN J GASTROENTEROL
JI Can. J. Gastroenterol. Hepatol.
PD JAN 12
PY 2021
VL 2021
AR 6696857
DI 10.1155/2021/6696857
PG 11
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA PZ9EE
UT WOS:000613049700002
PM 33505944
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Striegel, RH
   Bedrosian, R
   Wang, C
   Schwartz, S
AF Striegel, Ruth H.
   Bedrosian, Richard
   Wang, Chun
   Schwartz, Steven
TI Why Men Should Be Included in Research on Binge Eating: Results from a
   Comparison of Psychosocial Impairment in Men and Women
SO INTERNATIONAL JOURNAL OF EATING DISORDERS
LA English
DT Article
DE eating disorders; binge eating; obesity; metabolic syndrome; work
   productivity impairment; psychosocial impairment
ID GUIDED SELF-HELP; DISORDER SYMPTOMS; COMMUNITY SAMPLE; YOUNG-ADULTS;
   COMORBIDITY; PREVALENCE; VALIDITY; REPLICATION; DEPRESSION; OVERWEIGHT
AB Objective: Prevalence of binge eating has been shown to be as common in men as in women, yet few studies have included men. Men are especially underrepresented in treatment studies, raising the question of whether men who binge eat experience less distress or impairment than women. This study compared demographic and clinical correlates of binge eating in a large employee sample of men and women.
   Method: Cross-sectional data from 21,743 men and 24,608 women who participated in a health risk self assessment screening were used. Group differences in obesity, hypertension, dyslipidemia, Type 2 diabetes, depression, stress, sleep, sick days, work impairment, and non-work activity impairment were tested using chi-square tests (categorical variables) and independent sample t-tests (continuous variables).
   Results: Effect size estimates indicate that men (n = 1,630) and women (n = 2,754) who binge eat experience comparable levels of clinical impairment. They also report substantially greater impairment when compared with men and women who do not binge eat.
   Discussion: The underrepresentation of men in treatment-seeking samples does not appear to reflect lower levels of impairment in men versus women. Efforts are needed to raise awareness of the clinical significance of binge eating in men so that this group can receive appropriate screening and treatment services. (C) 2011 by Wiley Periodicals, Inc.
C1 [Striegel, Ruth H.] Wesleyan Univ, Dept Psychol, Middletown, CT 06459 USA.
   [Bedrosian, Richard; Wang, Chun; Schwartz, Steven] HealthMedia Inc, Ann Arbor, MI USA.
C3 Wesleyan University
RP Striegel, RH (corresponding author), Wesleyan Univ, Dept Psychol, 207 High St, Middletown, CT 06459 USA.
EM rstriegel@wesleyan.edu
OI Weissman, Ruth Striegel/0000-0001-6121-4641
FU HealthMedia, Inc.
FX Dr. Striegel-Moore was compensated by HealthMedia, Inc. for her work on
   this study. Drs. Bedrosian, Wang, and Schwartz are employees of
   HealthMedia, Inc.
CR Bedrosian RC, 2011, INT J EAT DISORDER, V44, P639, DOI 10.1002/eat.20844
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NR 27
TC 129
Z9 151
U1 0
U2 32
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0276-3478
J9 INT J EAT DISORDER
JI Int. J. Eating Disord.
PD MAR
PY 2012
VL 45
IS 2
BP 233
EP 240
DI 10.1002/eat.20962
PG 8
WC Psychology, Clinical; Nutrition & Dietetics; Psychiatry; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Nutrition & Dietetics; Psychiatry
GA 904WB
UT WOS:000301228500009
PM 22031213
DA 2025-06-11
ER

PT J
AU Chaabene, H
   Ramirez-Campillo, R
   Moran, J
   Schega, L
   Prieske, O
   Sandau, I
   Negra, Y
   Behrens, M
AF Chaabene, Helmi
   Ramirez-Campillo, Rodrigo
   Moran, Jason
   Schega, Lutz
   Prieske, Olaf
   Sandau, Ingo
   Negra, Yassine
   Behrens, Martin
TI The Era of Resistance Training as a Primary Form of Physical Activity
   for Physical Fitness and Health in Youth Has Come
SO SPORTS MEDICINE
LA English
DT Article; Early Access
ID BONE-MINERAL DENSITY; SKELETAL-MUSCLE HYPERTROPHY; RISK BEHAVIOR
   SURVEILLANCE; SPORTS-RELATED INJURIES; POSITION STATEMENT; AEROBIC
   EXERCISE; MUSCULAR FITNESS; BODY-COMPOSITION; CARDIORESPIRATORY FITNESS;
   CARDIOMETABOLIC RISK
AB Resistance training (RT) is widely regarded as the gold standard approach for enhancing muscular fitness (i.e., muscle strength, power, and muscular endurance) in youth while also providing health and physical fitness benefits traditionally associated with aerobic training (e.g., enhanced cardiorespiratory fitness, reduced body fat, improved insulin sensitivity). Additionally, while bone health can be improved following RT (particularly after plyometric jump training), aerobic training may result in a lesser or even neutral impact on bone mineral density enhancement (e.g., swimming). Regarding mental health and cognition, while aerobic training has well-established positive effects, preliminary evidence in obese youth suggests that RT may offer greater benefits in certain aspects compared to aerobic training. Additionally, RT can reduce the risk and incidence of injuries in youth. Overall, we argue in this Current Opinion article that the current consideration of RT as an additional, rather than essential (possibly even the most essential), aspect of physical activity in current national and international guidelines needs to be reconsidered. Overall, there is an urgent need to inform relevant stakeholders that, while aerobic activities remain essential, the next generation of physical activity guidelines should place greater emphasis on the particular importance of RT, providing more comprehensive guidance on its implementation for youth.
C1 [Chaabene, Helmi; Schega, Lutz] Otto von Guericke Univ, Chair Hlth & Phys Act, Dept Sport Sci, Magdeburg, Germany.
   [Chaabene, Helmi] Univ Jendouba, Inst Super Sport & Educ Phys Kef, Le Kef 7100, Tunisia.
   [Ramirez-Campillo, Rodrigo] Univ Andres Bello, Exercise & Rehabil Sci Inst, Fac Rehabil Sci, Sch Phys Therapy, Santiago 7591538, Chile.
   [Ramirez-Campillo, Rodrigo] Univ Tarapaca, Sport Sci & Human Performance Labs, Inst Alta Invest, Arica, Chile.
   [Moran, Jason] Univ Essex, Sch Sport Rehabil & Exercise Sci, Colchester, Essex, England.
   [Prieske, Olaf; Behrens, Martin] Univ Appl Sci Sport & Management Potsdam, Olymp Weg 7, D-14471 Potsdam, Germany.
   [Sandau, Ingo] Inst Appl Training Sci, Dept Strength Power & Tech Sports, Leipzig, Germany.
   [Negra, Yassine] Univ Manouba, Higher Inst Sport & Phys Educ Ksar Said, Res Unit UR17JS01 Sports Performance Hlth & Soc, La Manouba 2010, Tunisia.
   [Behrens, Martin] Rostock Univ, Med Ctr, Dept Orthopaed, Rostock, Germany.
C3 Otto von Guericke University; Universite de Jendouba; Universidad Andres
   Bello; Universidad de Tarapaca; University of Essex; Universite de la
   Manouba; University of Rostock
RP Chaabene, H (corresponding author), Otto von Guericke Univ, Chair Hlth & Phys Act, Dept Sport Sci, Magdeburg, Germany.; Chaabene, H (corresponding author), Univ Jendouba, Inst Super Sport & Educ Phys Kef, Le Kef 7100, Tunisia.
EM helmi.chaabane@ovgu.de
RI Negra, yassine/AAR-4942-2020; Ramirez-Campillo, Rodrigo/M-1258-2016;
   Prieske, Olaf/J-5221-2019; Behrens, Martin/H-8443-2019; Sandau,
   Ingo/LCD-9102-2024; Chaabene, Helmi/I-7317-2019
FU Projekt DEAL
FX Open Access funding enabled and organized by Projekt DEAL.
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NR 233
TC 0
Z9 0
U1 2
U2 2
PU ADIS INT LTD
PI NORTHCOTE
PA 5 THE WAREHOUSE WAY, NORTHCOTE 0627, AUCKLAND, NEW ZEALAND
SN 0112-1642
EI 1179-2035
J9 SPORTS MED
JI Sports Med.
PD 2025 MAY 26
PY 2025
DI 10.1007/s40279-025-02240-3
EA MAY 2025
PG 18
WC Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Sport Sciences
GA 2ZF7A
UT WOS:001494837800001
PM 40418528
DA 2025-06-11
ER

PT J
AU Eriksson, MD
   Eriksson, JG
   Korhonen, P
   Koponen, H
   Salonen, MK
   Mikkola, TM
   Kajantie, E
   Wasenius, NS
   von Bonsdorff, M
   Kautiainen, H
   Laine, MK
AF Eriksson, Mia D.
   Eriksson, Johan G.
   Korhonen, Paivi
   Koponen, Hannu
   Salonen, Minna K.
   Mikkola, Tuija M.
   Kajantie, Eero
   Wasenius, Niko S.
   von Bonsdorff, Mikaela
   Kautiainen, Hannu
   Laine, Merja K.
TI Depressive symptoms and mortality-findings from Helsinki birth cohort
   study
SO ACTA PSYCHIATRICA SCANDINAVICA
LA English
DT Article
DE cohort studies; comorbidity; depression; depressive disorder; mortality
ID ALL-CAUSE MORTALITY; METABOLIC SYNDROME; EXCESS MORTALITY; RISK-FACTOR;
   INTERVENTION; METAANALYSIS; ASSOCIATION; INVENTORY; DISEASE; HEALTH
AB Background Individuals with depression and depressive symptoms have a higher mortality rate than non-depressed individuals. The increased comorbidity and mortality associated with depression has remained largely unexplained. The underlying pathophysiological differences between depressive subtypes, melancholic and non-melancholic, may provide some explanation to this phenomenon. Methods One thousand nine hundred and ninety five participants (mean age 61 years) from the Helsinki Birth Cohort Study were recruited for this prospective study and followed up for a mean of 14.1 years. Information regarding medical history, lifestyle, and biochemical parameters were obtained. Depressive symptoms were assessed using the Beck Depression Inventory. Standardized mortality ratios were calculated. Results Participants were followed up for a total of 28,044 person-years. The melancholic depressive group had an increased adjusted risk of mortality [HR 1.49 (95% CI: 1.02-2.20)] when compared to the non-depressive group. Comparing mortality to the whole population of Finland using standardized mortality ratios (SMR) both the non-melancholic [1.11 (95% CI: 0.85-1.44)] and melancholic depressive [1.26 (95% CI: 0.87-1.81)] groups had higher mortality than the non-depressive group [0.82 (95% CI: 0.73-0.93)]. Conclusions Melancholic depressive symptoms are most strongly related to a higher mortality risk.
C1 [Eriksson, Mia D.; Eriksson, Johan G.; Wasenius, Niko S.; Laine, Merja K.] Univ Helsinki, Dept Gen Practice & Primary Hlth Care, Helsinki, Finland.
   [Eriksson, Mia D.; Eriksson, Johan G.; Koponen, Hannu; Wasenius, Niko S.; Laine, Merja K.] Helsinki Univ Hosp, Helsinki, Finland.
   [Eriksson, Mia D.; Eriksson, Johan G.; Salonen, Minna K.; Mikkola, Tuija M.; Wasenius, Niko S.; von Bonsdorff, Mikaela; Kautiainen, Hannu; Laine, Merja K.] Folkhalsan Res Ctr, Helsinki, Finland.
   [Eriksson, Mia D.] Univ Helsinki, Fac Med, Doctoral Programme Populat Hlth, Helsinki, Finland.
   [Eriksson, Johan G.] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Obstet & Gynecol, Singapore, Singapore.
   [Eriksson, Johan G.] Natl Univ Singapore, Yong Loo Lin Sch Med, Human Potential Translat Res Programme, Singapore, Singapore.
   [Eriksson, Johan G.] ASTAR, Singapore Inst Clin Sci SICS, Singapore, Singapore.
   [Korhonen, Paivi] Turku Univ Hosp, Turku, Finland.
   [Korhonen, Paivi] Univ Turku, Turku, Finland.
   [Koponen, Hannu] Univ Helsinki, Dept Psychiat, Helsinki, Finland.
   [Salonen, Minna K.; Kajantie, Eero] Finnish Inst Hlth & Welf, Dept Publ Hlth Solut, Publ Hlth Promot Unit, Helsinki, Finland.
   [Mikkola, Tuija M.] Univ Helsinki, Fac Med, Clinicum, Helsinki, Finland.
   [Kajantie, Eero] Oulu Univ Hosp, PEDEGO Res Unit, MRC Oulu, Oulu, Finland.
   [Kajantie, Eero] Univ Oulu, Oulu, Finland.
   [Kajantie, Eero] Norwegian Univ Sci & Technol, Dept Clin & Mol Med, Trondheim, Norway.
   [von Bonsdorff, Mikaela] Univ Jyvaskyla, Gerontol Res Ctr, Jyvaskyla, Finland.
   [von Bonsdorff, Mikaela] Univ Jyvaskyla, Fac Sport & Hlth Sci, Jyvaskyla, Finland.
   [Kautiainen, Hannu] Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland.
C3 University of Helsinki; University of Helsinki; Helsinki University
   Central Hospital; Folkhalsan Research Center; University of Helsinki;
   National University of Singapore; National University of Singapore;
   Agency for Science Technology & Research (A*STAR); A*STAR - Singapore
   Institute for Clinical Sciences (SICS); University of Turku; University
   of Turku; University of Helsinki; University of Helsinki; University of
   Oulu; University of Oulu; Norwegian University of Science & Technology
   (NTNU); University of Jyvaskyla; University of Jyvaskyla; University of
   Eastern Finland
RP Eriksson, MD (corresponding author), Univ Helsinki, Dept Gen Practice & Primary Hlth Care, Helsinki, Finland.; Eriksson, MD (corresponding author), Helsinki Univ Hosp, Helsinki, Finland.
EM mia.eriksson@helsinki.fi
RI Gibbs, J. Raphael/A-3984-2010; Wasenius, Niko/AAE-8927-2020; von
   Bonsdorff, Mikaela/A-5218-2015; /H-8100-2016; Mikkola, Tuija/L-2835-2014
OI Eriksson, Johan/0000-0002-2516-2060; von Bonsdorff,
   Mikaela/0000-0001-8530-5230; Koponen, Hannu/0000-0002-7368-1869;
   /0000-0002-1848-1514; Mikkola, Tuija/0000-0003-0885-2788; Eriksson,
   Mia/0000-0001-8968-8304; Wasenius, Niko/0000-0002-9007-6660
FU Academy of Finland; EU; European Commission; Finnish Special
   Governmental Subsidy for Health Sciences; Finska Lakaresallskapet;
   Foundation for Cardiovascular Research; Foundation for Diabetes
   Research; Foundation for Pediatric Research; Horizon2020; Medicinska
   Understodsforeningen Liv och Halsa; Novo Nordisk Foundation; Samfundet
   Folkhalsan; Signe ja Ane Gyllenbergin Saatio
FX Academy of Finland; EU; European Commission; Finnish Special
   Governmental Subsidy for Health Sciences; Finska Lakaresallskapet;
   Foundation for Cardiovascular Research; Foundation for Diabetes
   Research; Foundation for Pediatric Research; Horizon2020; Medicinska
   Understodsforeningen Liv och Halsa; Novo Nordisk Foundation; Samfundet
   Folkhalsan; Signe ja Ane Gyllenbergin Saatio
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NR 38
TC 8
Z9 8
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0001-690X
EI 1600-0447
J9 ACTA PSYCHIAT SCAND
JI Acta Psychiatr. Scand.
PD FEB
PY 2023
VL 147
IS 2
BP 175
EP 185
DI 10.1111/acps.13512
EA NOV 2022
PG 11
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 8D1PF
UT WOS:000877733700001
PM 36263580
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Chantler, PD
   Frisbee, JC
AF Chantler, Paul D.
   Frisbee, Jefferson C.
TI Arterial Function in Cardio-Metabolic Diseases: From the
   Microcirculation to the Large Conduits
SO PROGRESS IN CARDIOVASCULAR DISEASES
LA English
DT Review
DE Vascular disease; Metabolic syndrome; Obesity; Insulin resistance; Blood
   flow
ID TYPE-2 DIABETES-MELLITUS; INTIMA-MEDIA THICKNESS; INSULIN-RESISTANCE;
   RISK-FACTORS; MICROVASCULAR RAREFACTION; ENDOTHELIAL DYSFUNCTION;
   CARDIOVASCULAR EVENTS; INFLAMMATORY MARKERS; VASCULAR REACTIVITY;
   ANGIOTENSIN-II
AB The metabolic syndrome (MetS) is characterized as a constellation of metabolic risk factors such as obesity, hypertension, dyslipidemia, and hyperglycemia that co-occur within a given individual. This consultation of risk factors exposes MetS to a 3-fold increased risk of cardiovascular disease and an even higher risk of developing type 2 diabetes compared to healthy individuals. The pathophysiological mechanisms underlying this increased cardiovascular risk are incompletely understood but likely include alterations to macro- and micro-vasculature. The vasculature plays an important role not only in delivery and adjusting the quantity of blood delivered to the tissues, but the dynamic changes in structure and compliance significantly alter the hemodynamic stress imposed on the heart and end-organs. This review will give an overview of the pathophysiological changes to the vasculature that accompany MetS in both human and animal models, as well as the possible mechanistic pathways. (C) 2014 Elsevier Inc. All rights reserved.
C1 [Chantler, Paul D.] W Virginia Univ, Sch Med, Div Exercise Physiol, Morgantown, WV 26505 USA.
   [Chantler, Paul D.; Frisbee, Jefferson C.] W Virginia Univ, Sch Med, Ctr Cardiovasc & Resp Sci, Morgantown, WV 26505 USA.
   [Frisbee, Jefferson C.] W Virginia Univ, Sch Med, Dept Physiol & Pharmacol, Morgantown, WV 26505 USA.
C3 West Virginia University; West Virginia University; West Virginia
   University
RP Frisbee, JC (corresponding author), W Virginia Univ, POB 9229, Morgantown, WV 26505 USA.
EM jefrisbee@hsc.wvu.edu
OI Frisbee, Jefferson/0000-0003-2751-0599
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NR 87
TC 18
Z9 27
U1 0
U2 9
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0033-0620
EI 1873-1740
J9 PROG CARDIOVASC DIS
JI Prog. Cardiovasc. Dis.
PD MAR-APR
PY 2015
VL 57
IS 5
BP 489
EP 496
DI 10.1016/j.pcad.2014.09.005
PG 8
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA CE4NP
UT WOS:000351807600010
PM 25220256
DA 2025-06-11
ER

PT J
AU Sironi, AM
   Sicari, R
   Folli, F
   Gastaldelli, A
AF Sironi, Anna Maria
   Sicari, Rosa
   Folli, Franco
   Gastaldelli, Amalia
TI Ectopic Fat Storage, Insulin Resistance, and Hypertension
SO CURRENT PHARMACEUTICAL DESIGN
LA English
DT Review
DE Visceral fat; epicardial fat; hepatic fat; perivascular fat; pancreatic
   fat; metabolic syndrome; blood pressure
ID RENIN-ANGIOTENSIN SYSTEM; SYSTOLIC BLOOD-PRESSURE; BODY-MASS-INDEX;
   ADIPOSE-TISSUE; VISCERAL FAT; ARTERIAL-HYPERTENSION; ACUTE
   HYPERGLYCEMIA; ALDOSTERONE LEVELS; GENE-EXPRESSION; WEIGHT-LOSS
AB Obesity, insulin resistance, glucose intolerance/type 2 diabetes and hypertension are clustered in the metabolic syndrome representing critical risk factors for increased incidence cardio-cerebro-vascular diseases, kidney failure and cancer. Ectopic fat accumulation, i.e., accumulation in the mediastinum, liver and the abdomen, as well as generalized fat accumulation are associated with arterial hypertension, either systolic or diastolic. Several mechanisms including insulin resistance, sub-inflammatory state, increased Renin-Angiotensin-Aldosterone System (RAAS) system activity, oxidative stress, autonomic dysregulation as well as mechanical compression on the kidneys are all activated by obesity. Interestingly angiotensin-converting enzyme (ACE) inhibitors and angiotensin II (ATII) receptor blockers, while correcting arterial hypertension, also have a positive effect on glucose metabolism and diabetes prevention, in high risk patients. The implementation of dietary, medical and surgical strategies to prevent and treat obesity, are cornerstones for the primary prevention as well as treatment of arterial hypertension.
C1 [Sironi, Anna Maria; Sicari, Rosa; Gastaldelli, Amalia] CNR, Inst Clin Physiol, Pisa, Italy.
   [Folli, Franco; Gastaldelli, Amalia] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA.
C3 Consiglio Nazionale delle Ricerche (CNR); Istituto di Fisiologia Clinica
   (IFC-CNR); University of Texas System; University of Texas Health
   Science Center at San Antonio
RP Gastaldelli, A (corresponding author), CNR, Inst Clin Physiol, Pisa, Italy.
EM amalia.gastaldelli@ifc.cnr.it
RI folli, franco/J-2795-2018; Gastaldelli, Amalia/H-3319-2014
OI folli, franco/0000-0001-9824-5222; Gastaldelli,
   Amalia/0000-0003-2594-1651
FU Consiglio Nazionale delle Ricerche(CNR); European Foundation for the
   Study of Diabetes (EFSD)
FX This work was supported by funds of the Consiglio Nazionale delle
   Ricerche(CNR) and by a grant of the European Foundation for the Study of
   Diabetes (EFSD).
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NR 79
TC 20
Z9 25
U1 2
U2 13
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1381-6128
EI 1873-4286
J9 CURR PHARM DESIGN
JI Curr. Pharm. Design
PD SEP
PY 2011
VL 17
IS 28
BP 3074
EP 3080
PG 7
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 883KP
UT WOS:000299633200011
PM 21861830
DA 2025-06-11
ER

PT J
AU Prachayasittikul, V
   Prachayasittikul, S
   Ruchirawat, S
   Prachayasittikul, V
AF Prachayasittikul, Veda
   Prachayasittikul, Supaluk
   Ruchirawat, Somsak
   Prachayasittikul, Virapong
TI Coriander (Coriandrum sativum): A promising functional food
   toward the well-being
SO FOOD RESEARCH INTERNATIONAL
LA English
DT Review
DE Coriandrum sativum; Functional food; Linalool; Antioxidant;
   Neuroprotective; Metabolic syndrome
ID ESSENTIAL OIL COMPOSITION; L. ESSENTIAL OIL; PENTYLENETETRAZOLE-INDUCED
   SEIZURES; FATTY-ACID-COMPOSITION; IN-VITRO; ANTIOXIDANT ACTIVITY;
   SPILANTHES-ACMELLA; OXIDATIVE STRESS; BLOOD-PRESSURE; ASCORBIC-ACID
AB Coriandrum sativum (C. sativum) or coriander is one of the most popularly used spices in culinary worldwide, and its medicinal values has been recognized since ancient time. C. sativum contains bioactive phytochemicals that are accounted for a wide range of biological activities including antioxidant, anticancer, neuroprotective, anxiolytic, anticonvulsant, analgesic, migraine-relieving, hypolipidemic, hypoglycemic, hypotensive, antimicrobial, and antiinflammatory activities. The major compound, linalool, abundantly found in seeds is remarked for its abilities to modulate many key pathogenesis pathways of diseases. Apart from the modulating effects, the potent antioxidant property of the C. sativum provides a key mechanism behind its protective effects against neurodegenerative diseases, cancer, and metabolic syndrome. This review shed light on comprehensive aspects regarding the therapeutic values of the C. sativum, which indicate its significance of being a promising functional food for promoting the well-being in the era of aging and lifestyle-related diseases.
C1 [Prachayasittikul, Veda; Prachayasittikul, Supaluk] Mahidol Univ, Fac Med Technol, Ctr Data Min & Biomed Informat, Bangkok 10700, Thailand.
   [Ruchirawat, Somsak] Chulabhorn Res Inst, Lab Med Chem, Bangkok 10210, Thailand.
   [Ruchirawat, Somsak] Chulabhorn Grad Inst, Program Chem Biol, Bangkok 10210, Thailand.
   [Ruchirawat, Somsak] Minist Educ, Commiss Higher Educ, Ctr Excellence Environm Hlth & Toxicol, Bangkok, Thailand.
   [Prachayasittikul, Virapong] Mahidol Univ, Fac Med Technol, Dept Clin Microbiol & Appl Technol, Bangkok 10700, Thailand.
C3 Mahidol University; Chulabhorn Research Institute; Chulabhorn Graduate
   Institute; Mahidol University
RP Prachayasittikul, V (corresponding author), Mahidol Univ, Fac Med Technol, Ctr Data Min & Biomed Informat, Bangkok 10700, Thailand.
EM veda.pra@mahidol.ac.th
RI Prachayasittikul, Veda/J-2384-2019; Prachayasittikul,
   Supaluk/AAO-5375-2020
OI Prachayasittikul, Virapong/0000-0001-7942-1083; Prachayasittikul,
   Veda/0000-0001-6338-3721
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NR 293
TC 102
Z9 105
U1 4
U2 84
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0963-9969
EI 1873-7145
J9 FOOD RES INT
JI Food Res. Int.
PD MAR
PY 2018
VL 105
BP 305
EP 323
DI 10.1016/j.foodres.2017.11.019
PG 19
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA FW8GJ
UT WOS:000425567900032
PM 29433220
DA 2025-06-11
ER

PT J
AU Shibata, S
   Fujita, T
AF Shibata, Shigeru
   Fujita, Toshiro
TI The Kidneys and Aldosterone/Mineralocorticoid Receptor System in
   Salt-Sensitive Hypertension
SO CURRENT HYPERTENSION REPORTS
LA English
DT Article
DE Aldosterone; Mineralocorticoid receptor; Alternative pathway; Rac1;
   Salt-sensitive hypertension; Metabolic syndrome
ID EPITHELIAL SODIUM-CHANNEL; BLOOD-PRESSURE; MINERALOCORTICOID RECEPTOR;
   PRIMARY ALDOSTERONISM; OXIDATIVE STRESS; NA+ CHANNEL; ACTIVATION; SGK1;
   KINASE; RATS
AB Strong evidence supports the ability of the aldosterone/mineralocorticoid receptor (MR) system to dominate long-term blood pressure control. It is also increasingly recognized as an important mediator of cardiovascular and renal diseases, particularly in the presence of excessive salt intake. In a subgroup of individuals with metabolic syndrome, adipocyte-derived aldosterone-releasing factors cause inappropriate secretion of aldosterone in the adrenal glands during salt loading, resulting in the development of salt-induced hypertension and cardiac and renal damage. On the other hand, emerging data reveal that aldosterone is not a sole regulator of MR activity. We have identified the signaling crosstalk between MR and small GTPase Rac1 as a novel pathway to facilitate MR signaling. Such a local control system for MR can also be relevant to the pathogenesis of salt-sensitive hypertension, and future studies will clarify the detailed mechanism for the intricate regulation of the aldosterone/MR cascade.
C1 [Shibata, Shigeru; Fujita, Toshiro] Univ Tokyo, Grad Sch Med, Dept Nephrol & Endocrinol, Bunkyo Ku, Tokyo 1138655, Japan.
C3 University of Tokyo
RP Fujita, T (corresponding author), Univ Tokyo, Grad Sch Med, Dept Nephrol & Endocrinol, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1138655, Japan.
EM ssiba-tky@umin.ac.jp; fujita-dis@h.u-tokyo.ac.jp
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Z9 25
U1 0
U2 2
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1522-6417
EI 1534-3111
J9 CURR HYPERTENS REP
JI Curr. Hypertens. Rep.
PD APR
PY 2011
VL 13
IS 2
BP 109
EP 115
DI 10.1007/s11906-010-0175-6
PG 7
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 729CM
UT WOS:000287925700004
PM 21207253
OA Green Published, hybrid
DA 2025-06-11
ER

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   Yeung, EW
   Luecken, LJ
   Zautra, AJ
   Irwin, MR
AF Davis, Mary C.
   Lemery-Chalfant, Kathryn
   Yeung, Ellen WanHeung
   Luecken, Linda J.
   Zautra, Alex J.
   Irwin, Michael R.
TI Interleukin-6 and Depressive Mood Symptoms: Mediators of the Association
   Between Childhood Abuse and Cognitive Performance in Middle-Aged Adults
SO ANNALS OF BEHAVIORAL MEDICINE
LA English
DT Article
DE Childhood abuse; Depression; Metabolic risk; Inflammation;
   Interleukin-6; Cognitive function
ID EARLY-LIFE ADVERSITY; C-REACTIVE PROTEIN; METABOLIC SYNDROME;
   PHYSICAL-ACTIVITY; INFLAMMATION; DECLINE; STRESS; MARKERS; HEALTH; RISK
AB Background Childhood abuse is a risk factor for the development of cognitive deficits in adulthood, a relation that is likely mediated by stress-sensitive psychological and physiological indicators.
   Purpose To evaluate whether the link between exposure to childhood abuse and cognitive function in middle adulthood is mediated by interleukin-6 (IL-6), metabolic risk, and depressive mood symptoms.
   Methods Participants were 770 adults aged 40-65 recruited from the community, who completed the following: (i) a questionnaire assessing exposure to abuse prior to age 18, (ii) a phone interview assessing current depressive mood symptoms, and (iii) a home visit that included blood sampling for evaluation of IL-6 and assessment of metabolic risk indices. A follow-up telephone assessment evaluating cognitive function was completed by 555 of the participants. Structural equation modeling was used to test study hypotheses.
   Results Childhood abuse predicted higher levels of IL-6, depressive mood symptoms, and metabolic risk scores (p < .05). The relation between childhood abuse and poorer cognitive performance was mediated by IL-6 (p = .046) and depressive mood symptoms (p = .023), but not metabolic risk. IL-6 and depressive mood symptoms significantly mediated the relation between childhood abuse and adult cognitive function.
   Conclusions Exposure to early abuse conveys enduring physiological and psychological effects, which may contribute to cognitive deficits that are evident by middle adulthood. Increased vulnerability for cognitive decline among adults with a history of early trauma and the mediating roles of IL-6 and depressive mood symptoms point to the potential value of interventions that address inflammation or depression, singly or together, to prevent cognitive decline in this at-risk population.
C1 [Davis, Mary C.; Lemery-Chalfant, Kathryn; Luecken, Linda J.; Zautra, Alex J.] Arizona State Univ, Dept Psychol, Box 871104, Tempe, AZ 85287 USA.
   [Yeung, Ellen WanHeung] Univ Missouri, Dept Psychol Sci, Columbia, MO USA.
   [Irwin, Michael R.] Univ Calif Los Angeles, Cousins Ctr Psychoneuroimmunol, Los Angeles, CA USA.
   [Irwin, Michael R.] Univ Calif Los Angeles, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90024 USA.
C3 Arizona State University; Arizona State University-Tempe; University of
   Missouri System; University of Missouri Columbia; University of
   California System; University of California Los Angeles; University of
   California System; University of California Los Angeles
RP Davis, MC (corresponding author), Arizona State Univ, Dept Psychol, Box 871104, Tempe, AZ 85287 USA.
EM mary.davis@asu.edu
RI Luecken, Linda/K-6891-2013; Irwin, Michael/H-4870-2013
OI Irwin, Michael/0000-0002-1502-8431; Luecken, Linda/0000-0001-9383-1986;
   Lemery-Chalfant, Kathryn/0000-0003-4511-6501
FU National Institute on Aging [R01AG026006]; Eunice K. Shriver National
   Institute of Child Health and Human Development [R01HD086085]; National
   Institute on Alcohol Abuse and Alcoholism [T32AA013526]
FX This work was supported by funding from the National Institute on Aging
   (R01AG026006), the Eunice K. Shriver National Institute of Child Health
   and Human Development (R01HD086085), and the National Institute on
   Alcohol Abuse and Alcoholism (T32AA013526).
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NR 57
TC 23
Z9 25
U1 0
U2 11
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0883-6612
EI 1532-4796
J9 ANN BEHAV MED
JI Ann. Behav. Med.
PD JAN
PY 2019
VL 53
IS 1
BP 29
EP 38
DI 10.1093/abm/kay014
PG 10
WC Psychology, Multidisciplinary
WE Social Science Citation Index (SSCI)
SC Psychology
GA IQ5NE
UT WOS:000480798700003
PM 29562248
OA Green Published
DA 2025-06-11
ER

PT J
AU Vesoulis, ZA
   Diggs, S
   Brackett, C
   Sullivan, B
AF Vesoulis, Zachary A.
   Diggs, Stephanie
   Brackett, Cherise
   Sullivan, Brynne
TI Racial and geographic disparities in neonatal brain care
SO SEMINARS IN PERINATOLOGY
LA English
DT Review
DE Neonatal; Brain injury; IVH; Cerebral palsy; Racial disparities;
   Outcomes
ID ARTERIAL BLOOD-PRESSURE; INTRAVENTRICULAR HEMORRHAGE; PRETERM BIRTH;
   METABOLIC SYNDROME; PREMATURE-INFANTS; CEREBRAL-PALSY; UNITED-STATES;
   RISK-FACTORS; ETHNIC DISPARITIES; MATERNAL EDUCATION
AB In this review, we explore race-based disparities in neonatology and their impact on brain injury and neurodevelopmental outcomes. We discuss the historical context of healthcare discrimination, focusing on the postCivil War era and the segregation of healthcare facilities. We highlight the increasing disparity in infant mortality rates between Black and White infants, with premature birth being a major contributing factor, and emphasize the role of prenatal factors such as metabolic syndrome and toxic stress in affecting neonatal health. Furthermore, we examine the geographic and historical aspects of racial disparities, including the consequences of redlining and limited access to healthcare facilities or nutritious food options in Black communities. Finally, we delve into the higher incidence of brain injuries in Black neonates, as well as disparities in adverse neurodevelopmental outcome. This evidence underscores the need for comprehensive efforts to address systemic racism and provide equitable access to healthcare resources.
C1 [Vesoulis, Zachary A.; Diggs, Stephanie] Washington Univ, Sch Med, Dept Pediat, Div Newborn Med, St Louis, MO USA.
   [Brackett, Cherise; Sullivan, Brynne] Univ Virginia, Dept Pediat, Div Neonatol, Charlottesville, VA USA.
C3 Washington University (WUSTL); University of Virginia
RP Vesoulis, ZA (corresponding author), 660 S Euclid Ave,Campus Box 8116, St Louis, MO 63110 USA.
EM vesoulis_z@wustl.edu
RI Vesoulis, Zachary/J-1879-2019; Sullivan, Brynne/MIT-9690-2025
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NR 147
TC 0
Z9 0
U1 0
U2 1
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0146-0005
EI 1558-075X
J9 SEMIN PERINATOL
JI Semin. Perinatol.
PD AUG
PY 2024
VL 48
IS 5
AR 151925
DI 10.1016/j.semperi.2024.151925
EA AUG 2024
PG 8
WC Obstetrics & Gynecology; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology; Pediatrics
GA C4J1O
UT WOS:001289028900001
PM 38897830
OA hybrid
DA 2025-06-11
ER

PT J
AU McMullen, S
   Langley-Evans, SC
   Gambling, L
   Lang, C
   Swali, A
   McArdle, HJ
AF McMullen, S.
   Langley-Evans, S. C.
   Gambling, L.
   Lang, C.
   Swali, A.
   McArdle, H. J.
TI A common cause for a common phenotype: The gatekeeper hypothesis in
   fetal programming
SO MEDICAL HYPOTHESES
LA English
DT Article
ID LOW-PROTEIN-DIET; RENIN-ANGIOTENSIN SYSTEM; INTRAUTERINE
   GROWTH-RETARDATION; PITUITARY-ADRENAL AXIS; HIGH BLOOD-PRESSURE; JUNK
   FOOD DIET; DEVELOPMENTAL ORIGINS; RAT PREGNANCY; EPIGENETIC
   MODIFICATION; METABOLIC SYNDROME
AB Sub-optimal nutrition during pregnancy has been shown to have long-term effects on the health of offspring in both humans and animals. The most common outcomes of such programming are hypertension, obesity, dyslipidaemia and insulin resistance. This spectrum of disorders, collectively known as metabolic syndrome, appears to be the consequence of nutritional insult during early development, irrespective of the nutritional stress experienced. For example, diets low in protein diet, high in fat, or deficient in iron are all associated with programming of cardiovascular and metabolic disorders when fed during rat pregnancy. In this paper, we hypothesise that the nutritional stresses act on genes or gene pathways common to all of the insults. We have termed these genes and/or gene pathways the "gatekeepers" and hence developed the "gatekeeper hypothesis". In this paper, we examine the background to the hypothesis and postulate some possible mechanisms or pathways that may constitute programming gatekeepers. (C) 2011 Elsevier Ltd. All rights reserved.
C1 [Gambling, L.; Lang, C.; McArdle, H. J.] Univ Aberdeen, Rowett Inst Nutr & Hlth, Aberdeen AB21 9SB, Scotland.
   [McMullen, S.; Langley-Evans, S. C.; Swali, A.] Univ Nottingham, Sch Biosci, Loughborough LE12 5RD, Leics, England.
C3 University of Aberdeen; University of Nottingham
RP McArdle, HJ (corresponding author), Univ Aberdeen, Rowett Inst Nutr & Hlth, Greenburn Rd, Aberdeen AB21 9SB, Scotland.
EM h.mcardle@abdn.ac.uk
RI Langley-Evans, Simon/AAR-4181-2020; McMullen, Sarah/H-8652-2012
OI Langley-Evans, Simon/0000-0002-1969-8416; Swali,
   Angelina/0000-0002-6428-6373
FU BBSRC; Rural and Environmental Analytical Service (RERAS) of Scottish
   Government; BBSRC [BB/F005245/1] Funding Source: UKRI
FX SLE and SM, in collaboration with HJM and LG, hold funding with the
   BBSRC for a project testing the gatekeeper hypothesis. AS was funded by
   the BBSRC. HJM, LG and CL are supported by Rural and Environmental
   Analytical Service (RERAS) of Scottish Government.
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NR 86
TC 55
Z9 61
U1 0
U2 13
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0306-9877
J9 MED HYPOTHESES
JI Med. Hypotheses
PD JAN
PY 2012
VL 78
IS 1
BP 88
EP 94
DI 10.1016/j.mehy.2011.09.047
PG 7
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 881AZ
UT WOS:000299453000022
PM 22047985
OA hybrid, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Han, E
   Lee, YH
AF Han, Eugene
   Lee, Yong-ho
TI Non-Alcoholic Fatty Liver Disease: The Emerging Burden in
   Cardiometabolic and Renal Diseases
SO DIABETES & METABOLISM JOURNAL
LA English
DT Review
DE Arrhythmias; cardiac; Atherosclerosis; Diabetes mellitus; Hypertension;
   Insulin resistance; Metabolism; Non-alcoholic fatty liver disease;
   Obesity; Renal insufficiency; Stroke
ID TYPE-2 DIABETES-MELLITUS; INSULIN-RESISTANCE; CARDIOVASCULAR-DISEASE;
   FOLLOW-UP; METABOLIC SYNDROME; RISK-FACTOR; NAFLD; ASSOCIATION; OBESITY;
   DYSLIPIDEMIA
AB As the number of individuals with non-alcoholic fatty liver disease (NAFLD) has increased, the influence of NAFLD on other metabolic diseases has been highlighted. Accumulating epidemiologic evidence indicates that NAFLD not only affects the liver but also increases the risk of extra-hepatic diseases such as type 2 diabetes mellitus, metabolic syndrome, dyslipidemia, hypertension, cardiovascular or cerebrovascular diseases, and chronic kidney disease. Non-alcoholic steatohepatitis, an advanced type of NAFLD, can aggravate these inter-organ relationships and lead to poorer outcomes. NAFLD induces insulin resistance and exacerbates systemic chronic inflammation and oxidative stress, which leads to organ dysfunction in extra-hepatic tissues. Although more research is needed to identify the pathophysiological mechanisms and causal relationship between NAFLD and cardiometabolic and renal diseases, screening for heart, brain, and kidney diseases, risk assessment for diabetes, and a multidisciplinary approach for managing these patients should be highly encouraged.
C1 [Han, Eugene] Keimyung Univ, Div Endocrinol & Metab, Dept Internal Med, Sch Med, Daegu, South Korea.
   [Han, Eugene; Lee, Yong-ho] Yonsei Univ, Grad Sch, Coll Med, Seoul, South Korea.
   [Lee, Yong-ho] Yonsei Univ, Div Endocrinol & Metab, Dept Internal Med, Coll Med, 50-1 Yonsei Ro, Seoul 03722, South Korea.
C3 Keimyung University; Yonsei University; Yonsei University Health System;
   Yonsei University; Yonsei University Health System
RP Lee, YH (corresponding author), Yonsei Univ, Div Endocrinol & Metab, Dept Internal Med, Coll Med, 50-1 Yonsei Ro, Seoul 03722, South Korea.
EM yholee@yuhs.ac
RI Lee, Yong-ho/AAT-4106-2020
OI Lee, Yong-ho/0000-0002-6219-4942
FU Korea Healthcare Technology R&D Project, Ministry of Health and Welfare,
   Republic of Korea [HI17C0913]
FX This research was supported by the grant from the Korea Healthcare
   Technology R&D Project, Ministry of Health and Welfare, Republic of
   Korea (HI17C0913).
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NR 60
TC 61
Z9 65
U1 0
U2 5
PU KOREAN DIABETES ASSOC
PI SEOUL
PA 101-2104, LOTTE CASTLE PRES, 109 MAPO-DAERO, MAPO-GU, SEOUL, 04146,
   SOUTH KOREA
SN 2233-6079
EI 2233-6087
J9 DIABETES METAB J
JI Diabetes Metab. J.
PD DEC
PY 2017
VL 41
IS 6
BP 430
EP 437
DI 10.4093/dmj.2017.41.6.430
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA FR0PP
UT WOS:000418765500002
PM 29199410
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Murphy, AJ
   Kraakman, MJ
   Kammoun, HL
   Dragoljevic, D
   Lee, MKS
   Lawlor, KE
   Wentworth, JM
   Vasanthakumar, A
   Gerlic, M
   Whitehead, LW
   DiRago, L
   Cengia, L
   Lane, RM
   Metcalf, D
   Vince, JE
   Harrison, LC
   Kallies, A
   Kile, BT
   Croker, BA
   Febbraio, MA
   Masters, SL
AF Murphy, Andrew J.
   Kraakman, Michael J.
   Kammoun, Helene L.
   Dragoljevic, Dragana
   Lee, Man K. S.
   Lawlor, Kate E.
   Wentworth, John M.
   Vasanthakumar, Ajithkumar
   Gerlic, Motti
   Whitehead, Lachlan W.
   DiRago, Ladina
   Cengia, Louise
   Lane, Rachael M.
   Metcalf, Donald
   Vince, James E.
   Harrison, Leonard C.
   Kallies, Axel
   Kile, Benjamin T.
   Croker, Ben A.
   Febbraio, Mark A.
   Masters, Seth L.
TI IL-18 Production from the NLRP1 Inflammasome Prevents Obesity and
   Metabolic Syndrome
SO CELL METABOLISM
LA English
DT Article
ID TYPE-2 DIABETES-MELLITUS; INSULIN-RESISTANCE; WEIGHT-LOSS;
   ADIPOSE-TISSUE; INTERLEUKIN-18; ACTIVATION; MICE; ADIPONECTIN; CELLS
AB Interleukin-18 (IL-18) is activated by Caspase-1 in inflammasome complexes and has anti-obesity effects; however, it is not known which inflammasome regulates this process. We found that mice lacking the NLRP1 inflammasome phenocopy mice lacking IL-18, with spontaneous obesity due to intrinsic lipid accumulation. This is exacerbated when the mice are fed a high-fat diet (HFD) or a high-protein diet, but not when mice are fed a HFD with low energy density (high fiber). Furthermore, mice with an activating mutation in NLRP1, and hence increased IL-18, have decreased adiposity and are resistant to diet-induced metabolic dysfunction. Feeding these mice a HFD further increased plasma IL-18 concentrations and strikingly resulted in loss of adipose tissue mass and fatal cachexia, which could be prevented by genetic deletion of IL-18. Thus, NLRP1 is an innate immune sensor that functions in the context of metabolic stress to produce IL-18, preventing obesity and metabolic syndrome.
C1 [Murphy, Andrew J.; Kraakman, Michael J.; Kammoun, Helene L.; Dragoljevic, Dragana; Lee, Man K. S.] Baker IDI Heart & Diabet Inst, Haematopoiesis & Leukocyte Biol, Melbourne, Vic 3004, Australia.
   [Kammoun, Helene L.; Febbraio, Mark A.] Baker IDI Heart & Diabet Inst, Cellular & Mol Metab Lab, Melbourne, Vic 3004, Australia.
   [Murphy, Andrew J.; Dragoljevic, Dragana; Lee, Man K. S.] Monash Univ, Dept Immunol, Melbourne, Vic 3004, Australia.
   [Lawlor, Kate E.; Vince, James E.; Masters, Seth L.] Walter & Eliza Hall Inst Med Res, Div Inflammat, Parkville, Vic 3052, Australia.
   [Wentworth, John M.; Harrison, Leonard C.] Walter & Eliza Hall Inst Med Res, Div Mol Med, Parkville, Vic 3052, Australia.
   [Vasanthakumar, Ajithkumar; Kallies, Axel] Walter & Eliza Hall Inst Med Res, Div Immunol, Parkville, Vic 3052, Australia.
   [Lane, Rachael M.; Kile, Benjamin T.] Walter & Eliza Hall Inst Med Res, Div ACRF Chem Biol, Parkville, Vic 3052, Australia.
   [DiRago, Ladina; Cengia, Louise; Metcalf, Donald] Walter & Eliza Hall Inst Med Res, Div Canc & Hematol, Parkville, Vic 3052, Australia.
   [Whitehead, Lachlan W.] Walter & Eliza Hall Inst Med Res, Div Syst Biol & Personalised Med, Parkville, Vic 3052, Australia.
   [Lawlor, Kate E.; Wentworth, John M.; Vasanthakumar, Ajithkumar; Metcalf, Donald; Vince, James E.; Harrison, Leonard C.; Kallies, Axel; Kile, Benjamin T.; Masters, Seth L.] Univ Melbourne, Dept Med Biol, Parkville, Vic 3010, Australia.
   [Gerlic, Motti] Tel Aviv Univ, Sackler Fac Med, Dept Clin Microbiol & Immunol, IL-69978 Tel Aviv, Israel.
   [Croker, Ben A.] Harvard Univ, Sch Med, Boston Childrens Hosp, Div Hematol Oncol, Boston, MA 02115 USA.
   [Febbraio, Mark A.] St Vincents Hosp, Garvan Inst Med Res, Div Diabet & Metab, Darlinghurst, NSW 2010, Australia.
C3 Baker Heart and Diabetes Institute; Baker Heart and Diabetes Institute;
   Monash University; Walter & Eliza Hall Institute; Walter & Eliza Hall
   Institute; Walter & Eliza Hall Institute; Walter & Eliza Hall Institute;
   Walter & Eliza Hall Institute; Walter & Eliza Hall Institute; University
   of Melbourne; Tel Aviv University; Sackler Faculty of Medicine; Harvard
   University; Harvard University Medical Affiliates; Boston Children's
   Hospital; Harvard Medical School; Garvan Institute of Medical Research;
   NSW Health; St Vincents Hospital Sydney
RP Masters, SL (corresponding author), Walter & Eliza Hall Inst Med Res, Div Inflammat, Parkville, Vic 3052, Australia.; Masters, SL (corresponding author), Univ Melbourne, Dept Med Biol, Parkville, Vic 3010, Australia.
EM masters@wehi.edu.au
RI Febbraio, Mark/AAE-9632-2019; Dragoljevic, Dragana/JFK-2013-2023;
   Masters, Seth/LXA-3881-2024; Kile, Benjamin/F-6593-2011; gerlic,
   mordechay/U-3484-2017; masters, seth/N-2886-2013
OI Kile, Benjamin/0000-0002-8836-8947; gerlic,
   mordechay/0000-0001-9518-1833; masters, seth/0000-0003-4763-576X;
   Lawlor, Kate/0000-0003-0471-6842; Murphy, Andrew/0000-0001-7039-7777;
   VASANTHAKUMAR, AJITHKUMAR/0000-0002-1620-7781; Kallies,
   Axel/0000-0002-6312-6968; Febbraio, Mark/0000-0002-9296-4418; Kraakman,
   Michael/0000-0002-5755-0447; Wentworth, John/0000-0002-5197-3529;
   Croker, Ben/0000-0002-0885-3599
FU Australian National Health and Medical Research Council (NHMRC)
   [361646]; Australian Phenomics Network; Australian Cancer Research
   Foundation; Victorian State Government Operational Infrastructure
   Support Grant; National Heart Foundation; Diabetes Australia Research
   Trust Australia;  [637367];  [1002426];  [1051210];  [1057815]; 
   [461219];  [363652];  [1016647]
FX We thank L. Scott, R. Crawley, and K. Hay for outstanding animal
   husbandry. We also thank Prof A. Roberts (The Walter and Eliza Hall
   Institute) for assistance with mouse studies. This work was supported by
   Project Grants (637367, 1002426, 1051210, 1057815), Program Grants
   (461219, 363652, 1016647), Fellowships (S.L.M., B.T.K., M.A.F., A.J.M.,
   J.E.V.), and an Independent Research Institutes Infrastructure Support
   Scheme Grant (361646) from the Australian National Health and Medical
   Research Council (NHMRC); the Australian Phenomics Network, the
   Australian Cancer Research Foundation, and a Victorian State Government
   Operational Infrastructure Support Grant. A.J.M was also supported by a
   future leader fellowship from the National Heart Foundation, and a
   Viertel award from Diabetes Australia Research Trust Australia.
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NR 28
TC 143
Z9 150
U1 0
U2 16
PU CELL PRESS
PI CAMBRIDGE
PA 50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA
SN 1550-4131
EI 1932-7420
J9 CELL METAB
JI Cell Metab.
PD JAN 12
PY 2016
VL 23
IS 1
BP 155
EP 164
DI 10.1016/j.cmet.2015.09.024
PG 10
WC Cell Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Endocrinology & Metabolism
GA DI6MO
UT WOS:000373613400017
PM 26603191
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Kelsall, HL
   McKenzie, DP
   Sim, MR
   Leder, K
   Forbes, AB
   Dwyer, T
AF Kelsall, Helen L.
   McKenzie, Dean P.
   Sim, Malcolm R.
   Leder, Karin
   Forbes, Andrew B.
   Dwyer, Terence
TI Physical, Psychological, and Functional Comorbidities of Multisymptom
   Illness in Australian Male Veterans of the 1991 Gulf War
SO AMERICAN JOURNAL OF EPIDEMIOLOGY
LA English
DT Article
DE comorbidity; fatigue; Gulf War; psychology; quality of life; veterans
ID POSTTRAUMATIC-STRESS-DISORDER; METABOLIC SYNDROME; HEALTH-STATUS;
   SYMPTOMS; RISK; ASSOCIATION; DISTRESS
AB Multisymptom illness is more prevalent in 1991 Gulf War veterans than in military comparison groups; less is known about comorbidities. The authors compared physical, psychological, and functional comorbidities in Australian male Gulf War I veterans with those in actively (non-Gulf) deployed and nondeployed military personnel by using a questionnaire and medical assessment in 2000-2002. Multisymptom illness was more common in male Gulf War veterans than in the comparison group (odds ratio (OR) = 1.80, 95% confidence interval (CI): 1.48, 2.19). Stratifying by deployment status in the comparison group made little difference in this association. Gulf War veterans with multisymptom illness had increased psychiatric disorders, including major depression (OR = 6.31, 95% CI: 4.19, 9.52) and posttraumatic stress disorder (OR = 9.77, 95% CI: 5.39, 18.59); increased unexplained chronic fatigue (OR = 13.32, 95% CI: 7.70, 23.05); and more reported functional impairment and poorer quality of life, but objective physical and laboratory outcomes were similar to those for veterans without multisymptom illness. Similar patterns were found in the comparison groups; differences across the 3 groups were statistically significant for only hospitalization, obstructive liver disease, and Epstein-Barr virus exposure. Multisymptom illness is more prevalent in Gulf War I veterans, but the pattern of comorbidities is similar for actively deployed and nondeployed military personnel.
C1 [Kelsall, Helen L.; McKenzie, Dean P.; Sim, Malcolm R.; Leder, Karin; Forbes, Andrew B.] Monash Univ, Dept Epidemiol & Prevent Med, Melbourne, Vic 3004, Australia.
   [Kelsall, Helen L.] Canc Council Victoria, Canc Epidemiol Ctr, Carlton, Vic, Australia.
   [Dwyer, Terence] Royal Childrens Hosp, Murdoch Childrens Res Inst, Parkville, Vic 3052, Australia.
C3 Monash University; Cancer Council Victoria; Royal Children's Hospital
   Melbourne; Murdoch Children's Research Institute
RP Kelsall, HL (corresponding author), Monash Univ, Alfred Hosp, Monash Ctr Occupat & Environm Hlth, Dept Epidemiol & Prevent Med, Melbourne, Vic 3004, Australia.
EM helen.kelsall@med.monash.edu.au
RI Leder, Karin/AAD-2388-2019; Sim, Malcolm/I-2761-2014
OI Kelsall, Helen/0000-0003-0664-3376; Leder, Karin/0000-0003-1368-1039;
   Sim, Malcolm/0000-0003-4739-2817; Forbes, Andrew/0000-0003-4269-914X
FU National Health and Medical Research Foundation Public Health
   Postdoctoral Fellowship [384354, 465363]; Australian Government
   Department of Veterans' Affairs
FX This work was supported by a National Health and Medical Research
   Foundation Public Health Postdoctoral Fellowship (grant 384354 to H. K.)
   and a PhD scholarship (grant 465363 to D. M). The Australian Gulf War
   Veterans' Health Study was supported by the Australian Government
   Department of Veterans' Affairs.
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NR 50
TC 34
Z9 37
U1 0
U2 4
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0002-9262
EI 1476-6256
J9 AM J EPIDEMIOL
JI Am. J. Epidemiol.
PD OCT 15
PY 2009
VL 170
IS 8
BP 1048
EP 1056
DI 10.1093/aje/kwp238
PG 9
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA 502GT
UT WOS:000270445300015
PM 19762370
DA 2025-06-11
ER

PT J
AU Jamshed, H
   Beyl, RA
   Della Manna, DL
   Yang, ES
   Ravussin, E
   Peterson, CM
AF Jamshed, Humaira
   Beyl, Robbie A.
   Della Manna, Deborah L.
   Yang, Eddy S.
   Ravussin, Eric
   Peterson, Courtney M.
TI Early Time-Restricted Feeding Improves 24-Hour Glucose Levels and
   Affects Markers of the Circadian Clock, Aging, and Autophagy in Humans
SO NUTRIENTS
LA English
DT Article
DE intermittent fasting; time-restricted feeding; meal timing; circadian
   rhythms; circadian system
ID INTERMITTENT FASTING MODULATION; REDUCED MEAL FREQUENCY; WEIGHT-LOSS;
   CALORIC-INTAKE; INSULIN-RESISTANCE; DIABETIC SYNDROME; GENE-EXPRESSION;
   ACTIVE PHASE; BODY-FAT; HEALTHY
AB Time-restricted feeding (TRF) is a form of intermittent fasting that involves having a longer daily fasting period. Preliminary studies report that TRF improves cardiometabolic health in rodents and humans. Here, we performed the first study to determine how TRF affects gene expression, circulating hormones, and diurnal patterns in cardiometabolic risk factors in humans. Eleven overweight adults participated in a 4-day randomized crossover study where they ate between 8 am and 2 pm (early TRF (eTRF)) and between 8 am and 8 pm (control schedule). Participants underwent continuous glucose monitoring, and blood was drawn to assess cardiometabolic risk factors, hormones, and gene expression in whole blood cells. Relative to the control schedule, eTRF decreased mean 24-hour glucose levels by 4 +/- 1 mg/dl (p = 0.0003) and glycemic excursions by 12 +/- 3 mg/dl (p = 0.001). In the morning before breakfast, eTRF increased ketones, cholesterol, and the expression of the stress response and aging gene SIRT1 and the autophagy gene LC3A (all p < 0.04), while in the evening, it tended to increase brain-derived neurotropic factor (BNDF; p = 0.10) and also increased the expression of MTOR (p = 0.007), a major nutrient-sensing protein that regulates cell growth. eTRF also altered the diurnal patterns in cortisol and the expression of several circadian clock genes (p < 0.05). eTRF improves 24-hour glucose levels, alters lipid metabolism and circadian clock gene expression, and may also increase autophagy and have anti-aging effects in humans.
C1 [Jamshed, Humaira; Peterson, Courtney M.] Univ Alabama Birmingham, Dept Nutr Sci, Birmingham, AL 35294 USA.
   [Beyl, Robbie A.] Pennington Biomed Res Ctr, Biostat & Anal Lab, 6400 Perkins Rd, Baton Rouge, LA 70808 USA.
   [Della Manna, Deborah L.; Yang, Eddy S.] Univ Alabama Birmingham, Dept Radiat Oncol, Birmingham, AL 35294 USA.
   [Ravussin, Eric] Pennington Biomed Res Ctr, Translat Physiol Lab, 6400 Perkins Rd, Baton Rouge, LA 70808 USA.
C3 University of Alabama System; University of Alabama Birmingham;
   Louisiana State University System; Louisiana State University;
   Pennington Biomedical Research Center; University of Alabama System;
   University of Alabama Birmingham; Louisiana State University System;
   Louisiana State University; Pennington Biomedical Research Center
RP Peterson, CM (corresponding author), Univ Alabama Birmingham, Dept Nutr Sci, Birmingham, AL 35294 USA.
EM humaira.jphd@gmail.com; robbie.beyl@pbrc.edu; dellaman@uab.edu;
   eyang@uab.edu; eric.ravussin@pbrc.edu; cpeterso@uab.edu
RI Jamshed, Humaira/I-4739-2019; Beyl, Robbie/N-1951-2017; Ravussin,
   Eric/N-1985-2017
OI Ravussin, Eric/0000-0003-2129-547X; Jamshed, Humaira/0000-0002-3386-3748
FU Early Career Research Grant from The Obesity Society; NIH's National
   Center for Advancing Translational Sciences [KL2 TR001419]; NIH's
   National Institute of General Medical Sciences [U54 GM104940]; NORC
   Center Grant [P30 DK072476]
FX This research was funded by an Early Career Research Grant from The
   Obesity Society (C.M.P.); career development grants (to C.M.P.) under
   center grants KL2 TR001419 from the NIH's National Center for Advancing
   Translational Sciences and U54 GM104940 from NIH's National Institute of
   General Medical Sciences, which supports the Louisiana Clinical and
   Translational Science Center (LA CaTS); and a NORC Center Grant P30
   DK072476 entitled "Nutritional Programming: Environmental and Molecular
   Interactions" (E.R.). The content is solely the responsibility of the
   authors and does not necessarily represent the official views of the
   National Institutes of Health.
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NR 69
TC 430
Z9 470
U1 14
U2 194
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JUN
PY 2019
VL 11
IS 6
AR 1234
DI 10.3390/nu11061234
PG 16
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA II1AJ
UT WOS:000474936700040
PM 31151228
OA gold, Green Published, Green Submitted
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Ha, JH
   Park, S
   Yoon, D
   Kim, B
AF Ha, Jee Hyun
   Park, Soyeon
   Yoon, Daehyun
   Kim, Byungsu
TI Short-term heart rate variability in older patients with newly diagnosed
   depression
SO PSYCHIATRY RESEARCH
LA English
DT Article
DE Depression; Heart rate variability; HRV; Autonomic nervous system; Old
   age
ID MAJOR DEPRESSION; METABOLIC SYNDROME; NERVOUS-SYSTEM; DISEASE; RISK;
   MECHANISMS; MORTALITY; DISORDER
AB Dysfunction of the autonomic nervous system has been considered to be a risk factor for major depressive disorder (MDD) and cardiovascular disease (CVD). The aim of this study was to evaluate short-term heart rate variability (HRV) in elderly patients with newly diagnosed MDD. Thirty MDD patients over 60 years old newly diagnosed by a structured interview were enrolled, free from antidepressants. Socio-demographic data, blood tests, and heart rate variability (HRV) obtained from 5-min ECG were gathered. The MDD group showed significantly lower very low frequency power, low frequency power, high frequency power, and total power in frequency domain. In time domain analysis, the MDD group showed a significantly smaller standard deviation of the NN, root mean square of the differences of the successive NN, and NN50/total number of all NNs. These findings demonstrated a lower HRV in older patients who were newly diagnosed with depression without a history of CVD and antidepressants effect, compared with the control subjects. Low HRV may be an important predictor of both MDD and CVD in elderly. The use of HRV in elderly depressive patients could be a meaningful screening method for risk of CVD. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
C1 [Ha, Jee Hyun] Konkuk Univ, Sch Med, Dept Psychiat, Seoul, South Korea.
   [Park, Soyeon; Kim, Byungsu] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Psychiat, Seoul 136736, South Korea.
   [Yoon, Daehyun] Seoul Natl Univ Hosp, Dept Psychiat, Healthcare Syst Gangnam Ctr, Seoul 110744, South Korea.
   [Kim, Byungsu] Asan Med Ctr, Stress Clin, Hlth Promot Ctr, Seoul, South Korea.
C3 Konkuk University; Konkuk University Medical Center; University of
   Ulsan; Asan Medical Center; Seoul National University (SNU); Seoul
   National University Hospital; University of Ulsan; Asan Medical Center
RP Kim, B (corresponding author), Univ Ulsan, Coll Med, Asan Med Ctr, Dept Psychiat, 88 Olymp Ro 43 Gil, Seoul 136736, South Korea.
EM j993601@gmail.com
RI Kim, Byungsu/JNE-3151-2023
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NR 41
TC 29
Z9 33
U1 1
U2 25
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0165-1781
EI 1872-7123
J9 PSYCHIAT RES
JI Psychiatry Res.
PD APR
PY 2015
VL 226
IS 2-3
BP 484
EP 488
DI 10.1016/j.psychres.2015.02.005
PG 5
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA CG2HM
UT WOS:000353095500011
PM 25747680
DA 2025-06-11
ER

PT J
AU Chaudhary, K
   Buddineni, JP
   Nistala, R
   Whaley-Connell, A
AF Chaudhary, Kunal
   Buddineni, J. P.
   Nistala, Ravi
   Whaley-Connell, Adam
TI Resistant Hypertension in the High-Risk Metabolic Patient
SO CURRENT DIABETES REPORTS
LA English
DT Article
DE Resistant hypertension; Metabolic syndrome; Adiponectin
ID ANGIOTENSIN-ALDOSTERONE SYSTEM; NITRIC-OXIDE SYNTHASE;
   SMOOTH-MUSCLE-CELLS; II RECEPTOR BLOCKER; INSULIN-RESISTANCE;
   BLOOD-PRESSURE; ADIPOSE-TISSUE; MINERALOCORTICOID RECEPTOR;
   CARDIOMETABOLIC SYNDROME; VASCULAR INFLAMMATION
AB The metabolic syndrome is a constellation of metabolic and vascular abnormalities that include insulin resistance with compensatory hyperinsulinemia, central or visceral obesity, hypertension, dyslipidemia, microalbuminuria, and oxidative stress as well as prothrombotic and inflammatory abnormalities that contribute to a hypercoagulable state and systemic endothelial dysfunction. Visceral adipose tissue is now known to secrete into the circulation a number of protein and nonprotein factors that regulate glucose metabolism in traditional insulin-sensitive tissue as well as nontraditional insulin-sensitive tissue including cardiovascular tissue. Collectively, this constellation of factors that lead to metabolic dysregulation contributes to a substantial risk for adverse cardiovascular and renal outcomes. The development of a particularly resistant form of hypertension in these individuals can be attributed to a number of factors including vasoconstriction from increased sympathetic activation, proinflammatory cytokines, and inappropriate activation of the renin-angiotensin-aldosterone system. The management of hypertension in such patients can be challenging and generally requires nonpharmacologic as well as pharmacologic interventions.
C1 [Chaudhary, Kunal] Univ Missouri, Hlth Sci Ctr, Harry S Truman Hosp, Columbia, MO 65201 USA.
   [Buddineni, J. P.; Nistala, Ravi; Whaley-Connell, Adam] Univ Missouri, Sch Med, Columbia, MO 65201 USA.
   [Whaley-Connell, Adam] Harry S Truman VA Med Ctr, Columbia, MO USA.
C3 University of Missouri System; University of Missouri Columbia;
   University of Missouri System; University of Missouri Columbia; US
   Department of Veterans Affairs; Veterans Health Administration (VHA);
   Harry S. Truman Memorial Veterans' Hospital
RP Chaudhary, K (corresponding author), Univ Missouri, Hlth Sci Ctr, Harry S Truman Hosp, 800 Hosp Dr, Columbia, MO 65201 USA.
EM chaudharyk@health.missouri.edu
OI Whaley-Connell, Adam/0000-0001-8955-5560
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NR 63
TC 17
Z9 18
U1 0
U2 0
PU CURRENT MEDICINE GROUP
PI PHILADELPHIA
PA 400 MARKET STREET, STE 700, PHILADELPHIA, PA 19106 USA
SN 1534-4827
J9 CURR DIABETES REP
JI Curr. Diabetes Rep.
PD FEB
PY 2011
VL 11
IS 1
BP 41
EP 46
DI 10.1007/s11892-010-0155-x
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 729GA
UT WOS:000287935500006
PM 20941645
DA 2025-06-11
ER

PT S
AU Winer, N
   Sowers, JR
AF Winer, Nathaniel
   Sowers, James R.
BE Safar, ME
   Frohlich, ED
TI Diabetes and arterial stiffening
SO ATHEROSCLEROSIS, LARGE ARTERIES AND CARDIOVASCULAR RISK
SE Advances in Cardiology
LA English
DT Article
ID METABOLIC SYNDROME; CAROTID-ARTERY; STIFFNESS; GLUCOSE; INCREASES;
   DISEASE
AB Type 2 diabetes (DM-2) has become a major global health problem that has been fueled mainly by increasing obesity and aging of the population. Most studies show that arterial stiffening occurs across all age groups in both type I diabetes and DM-2, and among those with impaired fasting glucose, impaired glucose tolerance, and the metabolic syndrome. Arterial stiffening in DM-2 results, in part, from the clustering of hyperglycemia, dyslipidernia and hypertension, all of which may promote insulin resistance, oxidative stress, endothelial dysfunction, and the formation of pro-inflammatory cytokines and advanced glycosylation end-products. Likewise, aging may increase arterial stiffening by altering the proportions of elastin and collagen in the aorta. The consequences of arterial stiffening are increased pulse pressure, hypertension, and a greater risk of cardiovascular disease. Treatment strategies to reduce or prevent arterial stiffening include pharmacologic agents that block the renin-angiotensin-aldosterone system, relax vascular smooth muscle, enhance release of nitric oxide from endothelial cells, and break glycosylation end-product cross-links, and fish oil supplementation. Copyright (c) 2007 S. Karger AG, Basel.
C1 Suny Downstate Med Ctr, Div Endocrinol Diabet & Hypertens, New York, NY USA.
   Univ Missouri, Sch Med, Columbia, MO USA.
   Univ Missouri, Harry S Truman Vet Affairs Med Ctr, Columbia, MO USA.
C3 State University of New York (SUNY) System; SUNY Downstate Health
   Sciences University; University of Missouri System; University of
   Missouri Columbia; US Department of Veterans Affairs; Veterans Health
   Administration (VHA); Harry S. Truman Memorial Veterans' Hospital;
   University of Missouri System; University of Missouri Columbia
RP Winer, N (corresponding author), Suny Downstate Med Ctr, Div Endocrinol Diabet & Hypertens, Box 1205,450 Clarkson Ave, Brooklyn, NY 11203 USA.
EM nwiner@downstate.edu
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NR 28
TC 16
Z9 18
U1 0
U2 5
PU KARGER
PI BASEL
PA POSTFACH, CH-4009 BASEL, SWITZERLAND
SN 0065-2326
EI 1662-2839
BN 978-3-8055-8176-9
J9 ADV CARDIOL
JI Adv.Cardiol.
PY 2007
VL 44
BP 245
EP 251
PG 7
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA BFP84
UT WOS:000243670800018
PM 17075213
DA 2025-06-11
ER

PT J
AU Gallo, LC
   Carlson, JA
   Sotres-Alvarez, D
   Sallis, JF
   Jankowska, MM
   Roesch, SC
   Gonzalez, F
   Geremia, CM
   Talavera, GA
   Rodriguez, TM
   Castañeda, SF
   Allison, MA
AF Gallo, Linda C.
   Carlson, Jordan A.
   Sotres-Alvarez, Daniela
   Sallis, James F.
   Jankowska, Marta M.
   Roesch, Scott C.
   Gonzalez, Franklyn, II
   Geremia, Carrie M.
   Talavera, Gregory A.
   Rodriguez, Tasi M.
   Castaneda, Sheila F.
   Allison, Matthew A.
TI The Hispanic Community Health Study/Study of Latinos Community and
   Surrounding Areas Study: sample, design, and procedures
SO ANNALS OF EPIDEMIOLOGY
LA English
DT Article
DE Cardiovascular; Depression; Environment; Hispanic; Latino; Neighborhood;
   Physical activity; Risk factors
ID GEOGRAPHIC LIFE ENVIRONMENTS; PHYSICAL-ACTIVITY; BUILT ENVIRONMENT;
   METABOLIC SYNDROME; RISK-FACTORS; DIVERSE BACKGROUNDS; MICROSCALE AUDIT;
   HISPANICS/LATINOS; PREVALENCE; ASSOCIATIONS
AB Purpose: We describe the sample, design, and procedures for the Community and Surrounding Areas Study (CASAS), an ancillary to the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). The aim of SOL CASAS was to test an ecological model of macro- and micro-neighborhood environment factors, intermediate behavioral (physical activity) and psychosocial (e.g., depression and stress) mechanisms, and changes in cardiometabolic health in Hispanics/Latinos.
   Methods: Between 2015 and 2017, approximately 6 years after the HCHS/SOL baseline (2008-2011), 1776 San Diego HCHS/SOL participants enrolled in SOL CASAS and completed a repeat physical activity assessment. Participants' residential addresses were geoprocessed, and macroenvironmental features of the home were derived from publicly available data concurrent with the HCHS/SOL baseline and Visit 2 (2014-2017). Microscale environmental attributes were coded for 943 unique routes for 1684 participants, with a validated observational tool, concurrent with Visit 2, for SOL CASAS participants only.
   Results: Of 2520 HCHS/SOL participants approached, 70.5% enrolled (mean age 55.3 years; 94% Mexican; 67.5% female). Accelerometer adherence (three or more days with at least 10 hours wear time) was outstanding (94%).
   Conclusions: With its more comprehensive ecological model and well-characterized Hispanic/Latino population, SOL CASAS will advance the science concerning the contribution of neighborhood factors to cardiometabolic health. (C) 2018 Elsevier Inc. All rights reserved.
C1 [Gallo, Linda C.; Roesch, Scott C.] San Diego State Univ, Dept Psychol, San Diego, CA 92182 USA.
   [Carlson, Jordan A.] Childrens Mercy, Dept Pediat, Kansas City, MO USA.
   [Sotres-Alvarez, Daniela; Gonzalez, Franklyn, II] Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Biostat, Collaborat Studies Coordinating Ctr, Chapel Hill, NC 27515 USA.
   [Sallis, James F.; Geremia, Carrie M.; Allison, Matthew A.] Univ Calif San Diego, Sch Med, Dept Family Med & Publ Hlth, San Diego, CA 92103 USA.
   [Jankowska, Marta M.] Univ Calif San Diego, Qualcomm Inst, Calit2, San Diego, CA 92103 USA.
   [Talavera, Gregory A.; Castaneda, Sheila F.] San Diego State Univ, Sch Publ Hlth, San Diego, CA 92182 USA.
   [Rodriguez, Tasi M.] San Diego State Univ, Res Fdn, San Diego, CA 92182 USA.
C3 California State University System; San Diego State University;
   Children's Mercy Hospital; University of North Carolina; University of
   North Carolina Chapel Hill; University of California System; University
   of California San Diego; University of California System; University of
   California San Diego; California State University System; San Diego
   State University; California State University System; San Diego State
   University
RP Gallo, LC (corresponding author), San Diego State Univ, South Bay Latino Res Ctr, Dept Psychol, 780 Bay Blvd, Chula Vista, CA 91910 USA.
EM lgallo@sdsu.edu
RI Sotres-Alvarez, Daniela/O-9085-2016; Sallis, James/D-3001-2014;
   Castaneda, Sheila/AAK-3025-2020; Castaneda, Sheila/I-4132-2014
OI Geremia, Carrie/0000-0001-9159-8172; Castaneda,
   Sheila/0000-0002-1975-0544
FU National Heart, Lung, and Blood Institute
   [HHSN268201300001I/N01-HC-65233, HHSN268201300004I/N01-HC-65234,
   HHSN268201300002I/N01-HC-65235, HHSN268201300003I/N01-HC-65236,
   HHSN26820130000500I-HC-65237]; National Institutes of Health/National
   Institute of Diabetes and Digestive and Kidney Diseases [5 R01 DK106209]
FX The Hispanic Community Health Study/Study of Latinos is a collaborative
   study supported by contracts from the National Heart, Lung, and Blood
   Institute to the University of North Carolina
   (HHSN268201300001I/N01-HC-65233), University of Miami
   (HHSN268201300004I/N01-HC-65234), Albert Einstein College of Medicine
   (HHSN268201300002I/N01-HC-65235), University of Illinois at Chicago
   (HHSN268201300003I/N01-HC-65236 Northwestern University), and San Diego
   State University (HHSN26820130000500I-HC-65237). The following
   institutes/centers/offices have contributed to the HCHS/SOL through a
   transfer of funds to the NHLBI: National Institute on Minority Health
   and Health Disparities, National Institute on Deafness and Other
   Communication Disorders, National Institute of Dental and Craniofacial
   Research, National Institute of Diabetes and Digestive and Kidney
   Diseases, National Institute of Neurological Disorders and Stroke,
   Office of Dietary Supplements. SOL CASAS is supported by the National
   Institutes of Health/National Institute of Diabetes and Digestive and
   Kidney Diseases (5 R01 DK106209; Allison/Gallo mPls). The authors thank
   the staff and participants of HCHS/SOL and SOL CASAS for their important
   contributions.
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NR 54
TC 16
Z9 19
U1 1
U2 4
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1047-2797
EI 1873-2585
J9 ANN EPIDEMIOL
JI Ann. Epidemiol.
PD FEB
PY 2019
VL 30
BP 57
EP 65
DI 10.1016/j.annepidem.2018.11.002
PG 9
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA HM1RK
UT WOS:000459230100008
PM 30551973
OA Green Submitted, Green Accepted
DA 2025-06-11
ER

PT J
AU Ras, J
   Grace, J
AF Ras, Jaron
   Grace, Jeanne
TI Association Between Metabolic Syndrome and Physical Fitness in
   Firefighters in Cape Town, South Africa
SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
LA English
DT Article
DE aerobic capacity; cardiometabolic; endurance; fitness; hyperglycemia;
   hypertension; obesity; strength
ID CARDIORESPIRATORY FITNESS; MUSCULOSKELETAL HEALTH; PREVALENCE;
   PREDICTORS; STRENGTH; STRESS; RISK; MEN
AB Objective: To assess the relationship between metabolic syndrome (MetS) and physical fitness in firefighters. Methods: Firefighters (n = 309) were systematically recruited to participate in this study. A questionnaire and physical measures were used to collect data on firefighters' cardiometabolic health and physical fitness levels. Data were analyzed using binary and multinomial logistic regressions. Results: The prevalence of MetS was 23.0%, which was most prevalent in station and platoon commanders. Multivariable analysis showed that age (P < 0.001), lean body mass (P < 0.001), absolute aerobic capacity (P < 0.001), and leg strength (P < 0.001) was significantly associated with MetS. In addition, relative aerobic capacity (P < 0.001), push-ups (P = 0.016), and sit-ups (P < 0.001) were inversely associated with MetS. Conclusions: Firefighters with MetS had a higher absolute aerobic capacity and strength, and healthier fighters had a higher relative aerobic capacity, muscular endurance capacity, and flexibility.
C1 [Ras, Jaron; Grace, Jeanne] Univ Kwazulu Natal, Coll Hlth Sci, Discipline Biokinet Exercise & Leisure Sci, 238 Mazisi Kunene Rd, ZA-4041 Durban, South Africa.
C3 University of Kwazulu Natal
RP Ras, J (corresponding author), Univ Kwazulu Natal, Coll Hlth Sci, Discipline Biokinet Exercise & Leisure Sci, 238 Mazisi Kunene Rd, ZA-4041 Durban, South Africa.
EM rasj1@ukzn.ac.za; gracej@ukzn.ac.za
RI Ras, Jaron/KIX-7482-2024; Ras, Jaron/AAJ-9901-2021
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NR 58
TC 0
Z9 0
U1 1
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1076-2752
EI 1536-5948
J9 J OCCUP ENVIRON MED
JI J. Occup. Environ. Med.
PD DEC
PY 2024
VL 66
IS 12
BP e646
EP e652
DI 10.1097/JOM.0000000000003250
PG 7
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA O1L5I
UT WOS:001368827800008
PM 39621962
DA 2025-06-11
ER

PT J
AU Chambers, TJG
   Anderson, RA
AF Chambers, Thomas J. G.
   Anderson, Richard A.
TI The impact of obesity on male fertility
SO HORMONES-INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM
LA English
DT Review
DE Fertility; Hypogonadism; Infertility; Metabolic syndrome; Overweight;
   Paternal; Sperm
ID BODY-MASS INDEX; ASSISTED REPRODUCTIVE TECHNOLOGY; SEMEN QUALITY;
   METABOLIC SYNDROME; BARIATRIC SURGERY; PATERNAL OBESITY; OXIDATIVE
   STRESS; OLDER MEN; DIET; HYPOGONADISM
AB Obesity in men of reproductive age is globally on the increase. There is clear evidence from epidemiological studies that obesity impacts negatively on male fertility; it is associated with hypogonadism, although it is less consistently linked to impaired spermatogenesis and tests of sperm function, including DNA fragmentation. Sperm from obese men used for in vitro fertilisation/intra cytoplasmic sperm injection is associated with a greater number of pregnancy losses and is less likely to result in live births. There are also increasing data from animal studies that paternal obesity may impact negatively on the reproductive and metabolic health of offspring and grand-offspring. It has been suggested that high-fat dietary exposures could affect the epigenetic content of sperm or the endocrine content of seminal fluid and thus impact early fetal development. Experimental and epidemiological data show that male fertility, and offspring health, can be improved by weight loss in obese and overweight males.
C1 [Chambers, Thomas J. G.; Anderson, Richard A.] Univ Edinburgh, Queens Med Res Inst, MRC Ctr Reprod Hlth, 47 Little France Crescent, Edinburgh EH16 4TJ, Midlothian, Scotland.
C3 University of Edinburgh
RP Anderson, RA (corresponding author), Univ Edinburgh, Queens Med Res Inst, MRC Ctr Reprod Hlth, 47 Little France Crescent, Edinburgh EH16 4TJ, Midlothian, Scotland.
EM richard.anderson@ed.ac.uk
RI Chambers, Tom/AAJ-7880-2020
OI Chambers, Thomas/0000-0001-6823-6915
FU MRC [MR/K500938/1, G1002033] Funding Source: UKRI; Medical Research
   Council [G1002033, MR/K500938/1] Funding Source: Medline
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NR 54
TC 50
Z9 56
U1 1
U2 23
PU HELLENIC ENDOCRINE SOC
PI ATHENS
PA 14 ALEXANDRAS AVE, ATHENS, 106 82, GREECE
SN 1109-3099
J9 HORM-INT J ENDOCRINO
JI Horm.-Int. J. Endocrinol. Metab.
PD OCT-DEC
PY 2015
VL 14
IS 4
BP 563
EP 568
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA DD9KG
UT WOS:000370243500008
PM 26732149
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Robles-Almazan, M
   Pulido-Moran, M
   Moreno-Fernandez, J
   Ramirez-Tortosa, C
   Rodriguez-Garcia, C
   Quiles, JL
   Ramirez-Tortosa, M
AF Robles-Almazan, Maria
   Pulido-Moran, Mario
   Moreno-Fernandez, Jorge
   Ramirez-Tortosa, Cesar
   Rodriguez-Garcia, Carmen
   Quiles, Jose L.
   Ramirez-Tortosa, MCarmen
TI Hydroxytyrosol: Bioavailability, toxicity, and clinical applications
SO FOOD RESEARCH INTERNATIONAL
LA English
DT Review
DE Hydroxytyrosol; Olive oil; Chronic diseases; Inflammation; Reactive
   oxygen species (ROS); Cancer
ID VIRGIN OLIVE OIL; FATTY-ACID SYNTHASE; REDUCES OXIDATIVE STRESS; HUMAN
   HEPATOMA HEPG2; WASTE-WATER EXTRACT; INDUCED DNA-DAMAGE;
   PHENOLIC-COMPOUNDS; OLEA-EUROPAEA; IN-VITRO; METABOLIC SYNDROME
AB Many beneficial properties have been attributed to the Mediterranean diet. Over the years, researchers have attempted to learn which foods and which food components are responsible for good health. One of these components is hydroxytyrosol, an important phenolic compound present in olive oil.
   Hydroxytyrosol is a molecule of high interest to the pharmaceutical industry due to its anti-inflammatory and antimicrobial qualities its role against cardiovascular diseases and metabolic syndrome and for its neuroprotection, antitumour, and chemo modulation effects. The interest in this molecule has led to wide research on its biological activities, its beneficial effects in humans and how to synthetize new molecules from hydroxytyrosol.
   This review describes the vast range of information about hydroxytyrosol, focusing on its involvement in biological mechanisms and modulation effects on different pathologies. This review also serves to highlight the role of hydroxytyrosol as a nutraceutical and as a potential therapeutic agent.
C1 [Robles-Almazan, Maria; Ramirez-Tortosa, Cesar] Hosp Complex Jaen, Dept Pathol Anat, Ave Ejercito Espanol 10, Jaen 23007, Spain.
   [Pulido-Moran, Mario; Rodriguez-Garcia, Carmen; Ramirez-Tortosa, MCarmen] Univ Granada, Fac Pharm, Dept Biochem & Mol Biol 2, Univ Campus Cartuja, E-18071 Granada, Spain.
   [Moreno-Fernandez, Jorge] Univ Granada, Fac Pharm, Dept Physiol, Univ Campus Cartuja, E-18071 Granada, Spain.
   [Pulido-Moran, Mario; Moreno-Fernandez, Jorge; Rodriguez-Garcia, Carmen; Quiles, Jose L.; Ramirez-Tortosa, MCarmen] Univ Granada, Biomed Res Ctr, Inst Nutr & Food Technol Jose Mataix, Ave Conocimiento, Granada 18016, Spain.
C3 University of Granada; University of Granada; University of Granada
RP Ramirez-Tortosa, M (corresponding author), Univ Granada, Biomed Res Ctr, Inst Nutr & Food Technol Jose Mataix, Dept Biochem & Mol Biol 2, Granada 18016, Spain.
EM mramirez@ugr.es
RI Moreno-Fernandez, Jorge/L-2793-2017; RoblesAlmazan, Maria/LIC-6578-2024;
   Rodriguez Garcia, Carmen/ACH-8755-2022; Ramírez-Tortosa,
   César/F-2055-2016; Quiles, Jose L./C-6911-2013
OI Quiles, Jose L./0000-0002-9048-9086; Moreno-Fernandez,
   Jorge/0000-0001-9690-7851; Rodriguez Garcia, Carmen/0000-0002-4531-3188
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NR 179
TC 236
Z9 246
U1 12
U2 179
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0963-9969
EI 1873-7145
J9 FOOD RES INT
JI Food Res. Int.
PD MAR
PY 2018
VL 105
BP 654
EP 667
DI 10.1016/j.foodres.2017.11.053
PG 14
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA FW8GJ
UT WOS:000425567900068
PM 29433260
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Tana, C
   Tafuri, E
   Tana, M
   Martelletti, P
   Negro, A
   Affaitati, G
   Fabrizio, A
   Costantini, R
   Mezzetti, A
   Giamberardino, MA
AF Tana, Claudio
   Tafuri, Emmanuele
   Tana, Marco
   Martelletti, Paolo
   Negro, Andrea
   Affaitati, Giannapia
   Fabrizio, Alessandra
   Costantini, Raffaele
   Mezzetti, Andrea
   Giamberardino, Maria Adele
TI New insights into the cardiovascular risk of migraine and the role of
   white matter hyperintensities: is gold all that glitters?
SO JOURNAL OF HEADACHE AND PAIN
LA English
DT Review
DE Migraine; Cardiovascular events; Risk factors
ID ENDOTHELIAL PROGENITOR CELLS; TENSION-TYPE HEADACHE; SMALL VESSEL
   DISEASE; N-ACETYL-ASPARTATE; OXIDATIVE STRESS; ISCHEMIC-STROKE;
   METABOLIC SYNDROME; BRAIN-LESIONS; YOUNG-WOMEN; MRI
AB The role of migraine as an independent risk factor for cardiovascular events has been debated for several years, while it is more established for ischemic stroke. Recently, new studies have examined the likelihood of migraine to determine cardiovascular events, supporting the hypothesis of a predominant role in patients with migraine with aura, the risk including both sexes. In the literature, multiple pathophysiological mechanisms are described to explain this association, and are here discussed. Furthermore, the emerging evidence that a higher headache frequency and long-term migraine may worsen the cardio-metabolic profile in migraineurs (e. g. with a higher Framingham risk score and risk of developing atherosclerosis, insulin resistance and metabolic syndrome) makes it increasingly necessary to reduce the number and severity of attacks, not only to alleviate the painful symptoms, but also to improve the prognosis in these patients.
C1 [Tana, Claudio; Tafuri, Emmanuele; Tana, Marco; Affaitati, Giannapia; Fabrizio, Alessandra; Mezzetti, Andrea; Giamberardino, Maria Adele] Univ G dAnnunzio, Dept Med, Chieti, Italy.
   [Tana, Claudio; Tafuri, Emmanuele; Tana, Marco; Affaitati, Giannapia; Fabrizio, Alessandra; Mezzetti, Andrea; Giamberardino, Maria Adele] Univ G dAnnunzio, Ctr Excellence Aging, Chieti, Italy.
   [Tana, Claudio; Tafuri, Emmanuele; Fabrizio, Alessandra; Giamberardino, Maria Adele] SS Annunziata Hosp, Ctr Excellence Headache, Chieti, Italy.
   [Martelletti, Paolo; Negro, Andrea] Univ Roma La Sapienza, St Andrea Hosp, Reg Referral Headache Ctr, Dept Clin & Mol Med, Rome, Italy.
   [Costantini, Raffaele] Univ G DAnnunzio, Inst Surg Pathol, Chieti, Italy.
C3 G d'Annunzio University of Chieti-Pescara; G d'Annunzio University of
   Chieti-Pescara; Sapienza University Rome; Azienda Ospedaliera
   Sant'Andrea; G d'Annunzio University of Chieti-Pescara
RP Giamberardino, MA (corresponding author), Via Carlo de Tocco 3, I-66100 Chieti, Italy.
EM mag@unich.it
RI Tana, Marco/LOR-6880-2024; Tana, Claudio/L-5576-2019
OI Tana, Claudio/0000-0002-9162-7866; Martelletti,
   Paolo/0000-0002-6556-4128; Tana, Marco/0000-0002-0899-9870; Negro,
   Andrea/0000-0003-3590-298X
FU "G. D'Annunzio" University Funds
FX This study was supported by "G. D'Annunzio" University Funds for
   research to Maria Adele Giamberardino.
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NR 75
TC 49
Z9 49
U1 0
U2 31
PU SPRINGEROPEN
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 1129-2369
EI 1129-2377
J9 J HEADACHE PAIN
JI J. Headache Pain
PY 2013
VL 14
AR 9
DI 10.1186/1129-2377-14-9
PG 9
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 130MD
UT WOS:000317920400009
PM 23565964
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Cheung, O
   Sanyal, AJ
AF Cheung, Onpan
   Sanyal, Arun J.
TI Abnormalities of Lipid Metabolism in Nonalcoholic Fatty Liver Disease
SO SEMINARS IN LIVER DISEASE
LA English
DT Review
DE Nonalcoholic steatohepatitis; metabolic syndrome; insulin resistance; de
   novo lipogenesis; hepatic steatosis
ID ACTIVATED-RECEPTOR-ALPHA; ELEMENT-BINDING-PROTEIN; TRIGLYCERIDE TRANSFER
   PROTEIN; ENDOPLASMIC-RETICULUM STRESS; IMPROVES HEPATIC STEATOSIS;
   GENE-EXPRESSION; INSULIN-RESISTANCE; MITOCHONDRIAL DYSFUNCTION;
   BETA-OXIDATION; PPAR-GAMMA
AB Nonalcoholic fatty liver disease (NAFLD) is the most common liver abnormality in the United States and is strongly associated with the metabolic syndrome. Although many of the risk factors are well defined, the pathogenesis of NAFLD remains poorly understood. Recent studies have implicated several important cellular processes and signaling pathways that are affected by abnormal lipid metabolism, resulting in specific biochemical, histological, and clinical changes associated with NAFLD. Pharmacotherapy for NAFLD is limited and treatments are mainly to minimize risk factors. Understanding the disease pathogenesis is therefore important in identifying individuals with increased susceptibility for disease progression so lifestyle and risk modifications can be initiated early on. In this review, recent advances in the study of abnormal lipid metabolism and its impacts on histology and dysregulation of various cellular processes implicated in the genesis of NAFLD will be discussed.
C1 [Cheung, Onpan; Sanyal, Arun J.] Virginia Commonwealth Univ, Dept Internal Med, Div Gastroenterol Hepatol & Nutr, Med Ctr, Richmond, VA USA.
C3 Virginia Commonwealth University
RP Sanyal, AJ (corresponding author), MCV Box 980341, Richmond, VA 23298 USA.
EM ajsanyal@hsc.vcu.edu
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NR 95
TC 87
Z9 101
U1 2
U2 24
PU THIEME MEDICAL PUBL INC
PI NEW YORK
PA 333 SEVENTH AVE, NEW YORK, NY 10001 USA
SN 0272-8087
EI 1098-8971
J9 SEMIN LIVER DIS
JI Semin. Liver Dis.
PD NOV
PY 2008
VL 28
IS 4
BP 351
EP 359
DI 10.1055/s-0028-1091979
PG 9
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 370RG
UT WOS:000260779800003
PM 18956291
DA 2025-06-11
ER

PT J
AU Puttonen, S
   Härmä, M
   Hublin, C
AF Puttonen, Sampsa
   Harma, Mikko
   Hublin, Christer
TI Shift work and cardiovascular disease - pathways from circadian stress
   to morbidity
SO SCANDINAVIAN JOURNAL OF WORK ENVIRONMENT & HEALTH
LA English
DT Review
DE CHD; coronary heart disease; CHD; CVD; literature review; working hour
ID CORONARY-HEART-DISEASE; MALE JAPANESE WORKERS; AMBULATORY
   BLOOD-PRESSURE; MALE FACTORY-WORKERS; BODY-MASS INDEX; METABOLIC
   SYNDROME; SLEEP DURATION; RISK-FACTORS; FOLLOW-UP; RATE-VARIABILITY
AB In order to establish a causal relation between shift work and cardiovascular disease (CVD), we need to verify the pathways front the former to the latter. This paper aims to review the Current knowledge of the mechanisms between shift work and CVD. Shift work can increase the risk of CVD by several interrelated psychosocial, behavioral, and physiological mechanisms. The psychosocial mechanisms relate to difficulties in controlling working hours, decreased work life balance, and poor recovery following work. The most probable behavioral changes are weight gain and smoking. The plausible physiological and biological mechanisms are related to the activation of the autonomic nervous System, inflammation, changed lipid and glucose metabolism, and related changes in the risk for atherosclerosis, metabolic syndrome, and type 11 diabetes. The data provide evidence for possible disease mechanisms between shift work and CVD, but compelling evidence on any specific mechanism is missing.
C1 [Puttonen, Sampsa] Finnish Inst Occupat Hlth, Ctr Expertise Human Factors Work, FI-00250 Helsinki, Finland.
C3 Finnish Institute of Occupational Health
RP Puttonen, S (corresponding author), Finnish Inst Occupat Hlth, Ctr Expertise Human Factors Work, Topeliuksenkatu 41A A, FI-00250 Helsinki, Finland.
EM sampsa.puttonen@ttl.fi
RI Hublin, Christer/AAM-7105-2021
OI Puttonen, Sampsa/0000-0002-7796-6941
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NR 129
TC 387
Z9 430
U1 0
U2 58
PU SCANDINAVIAN JOURNAL WORK ENVIRONMENT & HEALTH
PI HELSINKI
PA TOPELIUKSENKATU 41A, SF-00250 HELSINKI, FINLAND
SN 0355-3140
EI 1795-990X
J9 SCAND J WORK ENV HEA
JI Scand. J. Work Environ. Health
PD MAR
PY 2010
VL 36
IS 2
SI SI
BP 96
EP 108
DI 10.5271/sjweh.2894
PG 13
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA 562TW
UT WOS:000275078800003
PM 20087536
OA hybrid
DA 2025-06-11
ER

PT J
AU Sevim, BC
   Chela, H
   Ertugrul, H
   Malik, LS
   Malik, S
   Basar, O
   Daglilar, E
   Samiullah, S
   Gaballah, AH
   Tahan, V
AF Sevim, Burak C. C.
   Chela, Harleen
   Ertugrul, Hamza
   Malik, Lyiba S. S.
   Malik, Suha
   Basar, Omer
   Daglilar, Ebubekir
   Samiullah, Sami
   Gaballah, Ayman H. H.
   Tahan, Veysel
TI Non-Alcoholic Fatty Pancreas Disease: The Unsung Disease
SO ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS
LA English
DT Review
DE Pancreatic cancer; fatty; pancreas; NAFPD; steatopancreatitis; obesity;
   non-alcoholic fatty liver disease
ID BETA-CELL FUNCTION; INSULIN-RESISTANCE; OXIDATIVE STRESS;
   ADIPOSE-TISSUE; LIVER-DISEASE; ECTOPIC FAT; HYPERECHOGENIC PANCREAS;
   DIAMOND-SYNDROME; RISK-FACTOR; STEATOSIS
AB Non-alcoholic fatty pancreas disease (NAFPD) is a relatively new and emerging disease that is increasingly diagnosed yearly, like non-alcoholic fatty liver disease (NAFLD). It is associated especially with metabolic syndrome and obesity. As awareness of pancreatic steatosis and its clinical implications increase, it is diagnosed more frequently. The researchers have explained the clinical importance of NAFPD and the diseases it causes, such as pancreatitis, pancreatic insufficiency, and pancreatic cancer. Although the definitive treatment is not yet established, the primary treatment approach is weight loss since NAFPD is associated with metabolic syndrome as well as obesity. Although pharmacological agents, such as oral hypoglycemic agents, have been investigated in animal experiments, studies on humans have not been conducted. Since the research on NAFPD is still insufficient, it is a subject that needs to be investigated, and further studies are needed to explore its pathophysiology, clinical impact, and its management.
C1 [Sevim, Burak C. C.; Gaballah, Ayman H. H.] Univ Missouri, Dept Radiol, Columbia, MO 65212 USA.
   [Chela, Harleen; Daglilar, Ebubekir] West Virginia Univ, Dept Internal Med, Div Gastroenterol, Charleston Campus, Charleston, WV USA.
   [Ertugrul, Hamza; Malik, Lyiba S. S.; Malik, Suha; Tahan, Veysel] Univ Missouri, Dept Internal Med, Div Gastroenterol & Hepatol, Columbia, MO 65212 USA.
   [Malik, Lyiba S. S.; Malik, Suha] Univ Wisconsin, Milwaukee Coll Letters & Sci, Milwaukee, WI USA.
   [Basar, Omer; Samiullah, Sami] Summa Hlth Syst, Dept Internal Med, Div Gastroenterol, Akron, OH USA.
   [Basar, Omer; Samiullah, Sami] Northeast Ohio Med Univ, Akron, OH USA.
   [Tahan, Veysel] Univ Missouri, Div Gastroenterol & Hepatol, Hosp Dr CE405, Columbia, MO 65212 USA.
C3 University of Missouri System; University of Missouri Columbia;
   University of Missouri System; University of Missouri Columbia;
   University of Wisconsin System; University of Wisconsin Milwaukee; Summa
   Health System; University System of Ohio; Northeast Ohio Medical
   University (NEOMED); University of Missouri System; University of
   Missouri Columbia
RP Tahan, V (corresponding author), Univ Missouri, Div Gastroenterol & Hepatol, Hosp Dr CE405, Columbia, MO 65212 USA.
EM tahanv@health.missouri.edu
RI Chela, Harleen/LYO-1450-2024; Tahan, Veysel/K-4806-2019
OI Tahan, Veysel/0000-0001-6796-9359
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NR 95
TC 2
Z9 2
U1 2
U2 8
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1871-5303
EI 2212-3873
J9 ENDOCR METAB IMMUNE
JI Endocr. Metab. Immune Disord.-Drug Targets
PY 2023
VL 23
IS 4
BP 485
EP 493
DI 10.2174/1871530322666220929142905
PG 9
WC Endocrinology & Metabolism; Immunology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Immunology; Pharmacology & Pharmacy
GA I8WD8
UT WOS:001005522900008
PM 36177623
DA 2025-06-11
ER

PT J
AU Giussani, DA
   Davidge, ST
AF Giussani, D. A.
   Davidge, S. T.
TI Developmental programming of cardiovascular disease by prenatal hypoxia
SO JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE
LA English
DT Review
DE cardiovascular dysfunction; fetal hypoxia; interventions; metabolic
   syndrome; treatment
ID INTRAUTERINE GROWTH RESTRICTION; PKC-EPSILON GENE; CHRONIC MODERATE
   HYPOXIA; INTIMA-MEDIA THICKNESS; HIGH-ALTITUDE HYPOXIA;
   LOW-BIRTH-WEIGHT; HIGH-FAT DIET; LONG-TERM; FETAL-GROWTH; ADULT MALE
AB It is now recognized that the quality of the fetal environment during early development is important in programming cardiovascular health and disease in later life. Fetal hypoxia is one of the most common consequences of complicated pregnancies worldwide. However, in contrast to the extensive research effort on pregnancy affected by maternal nutrition or maternal stress, the contribution of pregnancy affected by fetal chronic hypoxia to developmental programming is only recently becoming delineated and established. This review discusses the increasing body of evidence supporting the programming of cardiac susceptibility to ischaemia and reperfusion (I/R) injury, of endothelial dysfunction in peripheral resistance circulations, and of indices of the metabolic syndrome in adult offspring of hypoxic pregnancy. An additional focus of the review is the identification of plausible mechanisms and the implementation of maternal and early life interventions to protect against adverse programming.
C1 [Giussani, D. A.] Univ Cambridge, Dept Physiol Dev & Neurosci, Cambridge CB2 3EG, England.
   [Davidge, S. T.] Univ Alberta, Women & Childrens Hlth Res Inst, Dept Obstet & Gynecol, Edmonton, AB, Canada.
   [Davidge, S. T.] Univ Alberta, Women & Childrens Hlth Res Inst, Dept Physiol, Edmonton, AB, Canada.
C3 University of Cambridge; University of Alberta; University of Alberta
RP Giussani, DA (corresponding author), Univ Cambridge, Dept Physiol Dev & Neurosci, Downing St, Cambridge CB2 3EG, England.
EM dag26@cam.ac.uk
OI Giussani, Dino/0000-0002-1308-1204; Davidge, Sandra/0000-0002-5559-4905
FU British Heart Foundation; Biotechnology and Biological Sciences Research
   Council; Isaac Newton Trust; Canadian Institutes of Health Research
   (CIHR); Heart and Stroke Foundation of Canada; Women and Children's
   Health Research Institute of the University of Alberta; BBSRC
   [BB/E002668/1] Funding Source: UKRI
FX D.G. is supported by The British Heart Foundation, The Biotechnology and
   Biological Sciences Research Council and the Isaac Newton Trust. S. D.
   is supported by the Canadian Institutes of Health Research (CIHR), Heart
   and Stroke Foundation of Canada and the Women and Children's Health
   Research Institute of the University of Alberta.
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NR 127
TC 152
Z9 162
U1 0
U2 35
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 2040-1744
EI 2040-1752
J9 J DEV ORIG HLTH DIS
JI J. Dev. Orig. Health Dis.
PD OCT
PY 2013
VL 4
IS 5
BP 328
EP 337
DI 10.1017/S204017441300010X
PG 10
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA 210QQ
UT WOS:000323849900002
PM 24970726
OA Bronze
DA 2025-06-11
ER

PT J
AU Garbarino, J
   Sturley, SL
AF Garbarino, Jeanne
   Sturley, Stephen L.
TI Saturated with fat: new parspectives on lipotoxicity
SO CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE
LA English
DT Article
DE acyltransferases; fatty acids; insulin resistance; lipotoxicity;
   metabolic syndrome; neutral lipids
ID PANCREATIC BETA-CELL; ENDOPLASMIC-RETICULUM STRESS; YEAST
   SACCHAROMYCES-CEREVISIAE; PALMITATE-INDUCED APOPTOSIS; LONG-TERM
   EXPOSURE; FACTOR-KAPPA-B; MALONYL-COA; DIABETES-MELLITUS;
   ENDOTHELIAL-CELLS; ADIPOSE-TISSUE
AB Purpose of review
   To present current perspectives on the mediators and mechanisms of cyto-lipotoxic events and their relevance to human health.
   Recent findings
   The relatively recent isolation of lipid acyltransferase genes from yeast to mice and humans has resulted in a paradigm shift that now establishes all fatty acids as toxic, albeit in tissue specific patterns and by different mechanisms. Furthermore, the dysregulation of glucose homeostasis in combination with excess fatty acids provides a synergistic effect leading to glucolipotoxicity and cell death. These findings are relevant to the development of disease states associated with the pathogenesis of the metabolic syndrome.
   Summary
   In an era when an astounding number of people are diagnosed with metabolic disorders, it is imperative that we understand the consequences of a chronic metabolic surplus. Excessive fat, saturated or otherwise, has to be accommodated. Multiple aspects of this homeostasis are emerging, some of which are described here.
C1 [Sturley, Stephen L.] Columbia Univ, Med Ctr, Dept Pediat, New York, NY 10032 USA.
   [Garbarino, Jeanne; Sturley, Stephen L.] Columbia Univ, Med Ctr, Inst Human Nutr, New York, NY 10032 USA.
C3 Columbia University; Columbia University
RP Sturley, SL (corresponding author), Columbia Univ, Med Ctr, Dept Pediat, 630 W168th St, New York, NY 10032 USA.
EM sls37@columbia.edu
FU NIH [T32 DK007647]; American Diabetes Association; American Heart
   Association
FX This work was supported by the NIH, the American Diabetes Association
   and the American Heart Association (to SLS). JG received an NIH
   precloctoral fellowship in Nutrition (T32 DK007647).
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NR 81
TC 107
Z9 119
U1 0
U2 13
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1363-1950
EI 1473-6519
J9 CURR OPIN CLIN NUTR
JI Curr. Opin. Clin. Nutr. Metab. Care
PD MAR
PY 2009
VL 12
IS 2
BP 110
EP 116
DI 10.1097/MCO.0b013e32832182ee
PG 7
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 420DK
UT WOS:000264268500002
PM 19202381
DA 2025-06-11
ER

PT J
AU Luo, QY
   Wei, Y
   Lv, XZ
   Chen, W
   Yang, DM
   Tuo, Q
AF Luo, Quanye
   Wei, Yu
   Lv, Xuzhen
   Chen, Wen
   Yang, Dongmei
   Tuo, Qinhui
TI The Effect and Mechanism of Oleanolic Acid in the Treatment of Metabolic
   Syndrome and Related Cardiovascular Diseases
SO MOLECULES
LA English
DT Review
DE oleanolic acid; metabolic syndrome; cardiovascular diseases
ID ORUJO OLIVE OIL; NF-KAPPA-B; INSULIN-RESISTANCE; OXIDATIVE STRESS;
   HIGH-FAT; DIABETIC-NEPHROPATHY; ENDOTHELIAL FUNCTION;
   MYOCARDIAL-ISCHEMIA; IN-VIVO; ANTIOXIDANT
AB Metabolic syndromes (MetS) and related cardiovascular diseases (CVDs) pose a serious threat to human health. MetS are metabolic disorders characterized by obesity, dyslipidemia, and hypertension, which increase the risk of CVDs' initiation and development. Although there are many availabile drugs for treating MetS and related CVDs, some side effects also occur. Considering the low-level side effects, many natural products have been tried to treat MetS and CVDs. A five-cyclic triterpenoid natural product, oleanolic acid (OA), has been reported to have many pharmacologic actions such as anti-hypertension, anti-hyperlipidemia, and liver protection. OA has specific advantages in the treatment of MetS and CVDs. OA achieves therapeutic effects through a variety of pathways, attracting great interest and playing a vital role in the treatment of MetS and CVDs. Consequently, in this article, we aim to review the pharmacological actions and potential mechanisms of OA in treating MetS and related CVDs.
C1 [Luo, Quanye; Wei, Yu; Chen, Wen; Yang, Dongmei; Tuo, Qinhui] Hunan Univ Chinese Med, Med Sch, Key Lab Vasc Biol & Translat Med, Changsha 410208, Peoples R China.
   [Lv, Xuzhen] Hunan Univ Chinese Med, Sch Pharm, Key Lab Qual Evaluat Bulk Herbs Hunan Prov, Changsha 410208, Peoples R China.
C3 Hunan University of Chinese Medicine; Hunan University of Chinese
   Medicine
RP Yang, DM; Tuo, Q (corresponding author), Hunan Univ Chinese Med, Med Sch, Key Lab Vasc Biol & Translat Med, Changsha 410208, Peoples R China.
EM 20223777@stu.hnucm.edu.cn; 20223776@stu.hnucm.edu.cn;
   20232054@stu.hnucm.edu.cn; chenwen@biochen.org; dongmeiy@hnucm.edu.cn;
   qinhuituo@hnucm.edu.cn
OI Chen, Wen/0000-0002-9522-4036; Luo, Quanye/0009-0008-5640-799X
FU Key Research and Development Projects of the Hunan Provincial Science
   and Technology Department
FX No Statement Available
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NR 168
TC 8
Z9 8
U1 4
U2 15
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1420-3049
J9 MOLECULES
JI Molecules
PD FEB
PY 2024
VL 29
IS 4
AR 758
DI 10.3390/molecules29040758
PG 23
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA JI9R4
UT WOS:001172658900001
PM 38398510
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Gillies, NA
   Franzke, B
   Wessner, B
   Schober-Halper, B
   Hofmann, M
   Oesen, S
   Tosevska, A
   Strasser, EM
   Roy, NC
   Milan, AM
   Cameron-Smith, D
   Wagner, KH
AF Gillies, Nicola A.
   Franzke, Bernhard
   Wessner, Barbara
   Schober-Halper, Barbara
   Hofmann, Marlene
   Oesen, Stefan
   Tosevska, Anela
   Strasser, Eva-Maria
   Roy, Nicole C.
   Milan, Amber M.
   Cameron-Smith, David
   Wagner, Karl-Heinz
TI Nutritional supplementation alters associations between one-carbon
   metabolites and cardiometabolic risk profiles in older adults: a
   secondary analysis of the Vienna Active Ageing Study
SO EUROPEAN JOURNAL OF NUTRITION
LA English
DT Article
DE Choline; Homocysteine; Nutritional supplement; Older adults; One-carbon
   metabolism
ID PLASMA HOMOCYSTEINE; PHYSICAL-ACTIVITY; CARDIOVASCULAR-DISEASE;
   RESISTANCE EXERCISE; CHOLINE METABOLITES; OXIDATIVE STRESS;
   UNITED-STATES; ELDERLY-MEN; BETAINE; FOLATE
AB Purpose Cardiovascular diseases and cognitive decline, predominant in ageing populations, share common features of dysregulated one-carbon (1C) and cardiometabolic homeostasis. However, few studies have addressed the impact of multifaceted lifestyle interventions in older adults that combine both nutritional supplementation and resistance training on the co-regulation of 1C metabolites and cardiometabolic markers. Methods 95 institutionalised older adults (83 +/- 6 years, 88.4% female) were randomised to receive resistance training with or without nutritional supplementation (Fortifit), or cognitive training (control for socialisation) for 6 months. Fasting plasma 1C metabolite concentrations, analysed by liquid chromatography coupled with mass spectrometry, and cardiometabolic parameters were measured at baseline and the 3- and 6-month follow-ups. Results Regardless of the intervention group, choline was elevated after 3 months, while cysteine and methionine remained elevated after 6 months (mixed model time effects, p < 0.05). Elevated dimethylglycine and lower betaine concentrations were correlated with an unfavourable cardiometabolic profile at baseline (spearman correlations, p < 0.05). However, increasing choline and dimethylglycine concentrations were associated with improvements in lipid metabolism in those receiving supplementation (regression model interaction, p < 0.05). Conclusion Choline metabolites, including choline, betaine and dimethylglycine, were central to the co-regulation of 1C metabolism and cardiometabolic health in older adults. Metabolites that indicate upregulated betaine-dependent homocysteine remethylation were elevated in those with the greatest cardiometabolic risk at baseline, but associated with improvements in lipid parameters following resistance training with nutritional supplementation. The relevance of how 1C metabolite status might be optimised to protect against cardiometabolic dysregulation requires further attention.
C1 [Gillies, Nicola A.; Roy, Nicole C.; Milan, Amber M.; Cameron-Smith, David] Univ Auckland, Liggins Inst, Auckland, New Zealand.
   [Gillies, Nicola A.; Roy, Nicole C.; Cameron-Smith, David] Riddet Inst, Palmerston North, New Zealand.
   [Franzke, Bernhard; Wessner, Barbara; Schober-Halper, Barbara; Hofmann, Marlene; Oesen, Stefan; Tosevska, Anela; Wagner, Karl-Heinz] Univ Vienna, Res Platform Act Ageing, Althanstr 14, A-1090 Vienna, Austria.
   [Wessner, Barbara] Univ Vienna, Dept Sports Med Exercise Physiol & Prevent, Vienna, Austria.
   [Tosevska, Anela] Med Univ Vienna, Div Rheumatol, Internal Med 3, Vienna, Austria.
   [Strasser, Eva-Maria] Kaiser Franz Josef Hosp, Social Med Ctr South, Inst Phys Med & Rehabil, Vienna, Austria.
   [Roy, Nicole C.; Milan, Amber M.] AgResearch, Food Nutr & Hlth, Hamilton, New Zealand.
   [Roy, Nicole C.; Milan, Amber M.] High Value Nutr Natl Sci Challenge, Auckland, New Zealand.
   [Roy, Nicole C.] Univ Otago, Dept Human Nutr, Dunedin, New Zealand.
   [Cameron-Smith, David] Agcy Sci Technol & Res, Singapore Inst Clin Sci, Singapore, Singapore.
   [Wagner, Karl-Heinz] Univ Vienna, Dept Nutr Sci, Vienna, Austria.
C3 University of Auckland; University of Vienna; University of Vienna;
   Medical University of Vienna; Kaiser-Franz-Josef Hospital; AgResearch -
   New Zealand; University of Otago; Agency for Science Technology &
   Research (A*STAR); A*STAR - Singapore Institute for Clinical Sciences
   (SICS); University of Vienna
RP Wagner, KH (corresponding author), Univ Vienna, Res Platform Act Ageing, Althanstr 14, A-1090 Vienna, Austria.; Wagner, KH (corresponding author), Univ Vienna, Dept Nutr Sci, Vienna, Austria.
EM karl-heinz.wagner@univie.ac.at
RI Roy, Nicole/AAP-5016-2020; Milan, Amber/I-5680-2019; Franzke,
   Bernhard/AEJ-8037-2022; Wagner, Karl-Heinz/B-9098-2013; Wessner,
   Barbara/J-8244-2012
OI Tosevska, Anela/0000-0002-0892-7068; Gillies,
   Nicola/0000-0002-1280-5725; Cameron-Smith, David/0000-0002-0144-5816;
   Franzke, Bernhard/0000-0001-6762-2777; Wagner,
   Karl-Heinz/0000-0002-1683-7265; Wessner, Barbara/0000-0002-9061-7914
FU University of Auckland; Hope Foundation
FX We thank the Curatorship of Viennese Retirement Homes and its residents
   for taking part in the study. We thank Dr Matthew Barnett for the
   coordination of the AgResearch Ltd Strategic Science Investment Fund.
   Nicola Gillies thanks Professor Clare Wall and Professor Richard Mithen
   for PhD supervision, and the University of Auckland and the Hope
   Foundation for scholarship support.
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NR 66
TC 5
Z9 5
U1 0
U2 7
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1436-6207
EI 1436-6215
J9 EUR J NUTR
JI Eur. J. Nutr.
PD FEB
PY 2022
VL 61
IS 1
BP 169
EP 182
DI 10.1007/s00394-021-02607-y
EA JUL 2021
PG 14
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA YL0UA
UT WOS:000670863900001
PM 34240265
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Takemori, K
   Yoshimoto, K
   Aoki, K
   Matsuo, T
   Kometani, T
AF Takemori, Kumiko
   Yoshimoto, Kaito
   Aoki, Kana
   Matsuo, Takuya
   Kometani, Takashi
TI Development of pups born to rats established as a model of underweight
   Japanese women and the onset of impaired glucose tolerance
SO BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
LA English
DT Article
DE Developmental Origins of Health and Disease; intrauterine environment;
   metabolic syndrome; rat model; undernutrition
ID PROTEIN RESTRICTION; UNDERNUTRITION; MUSCLE; PREGNANCY; GROWTH; FOXO1
AB An increasing number of Japanese women of childbearing age are underweight (BMI <18.5), but the association between this and the increased number of low-birth-weight babies born remains unclear. Here, a rat model was established to mimic the undernutrition (85% of the energy required for those with normal activity levels) experienced by such women and to evaluate the associated impaired glucose tolerance. The undernourished Wistar rat group showed increased serum corticosterone level reflecting stress, and greater adrenal weight and size. It also showed greater insulin resistance, higher expression of FOXO-1, a transcription factor related to muscle atrophy, and lower expression of p-Akt, an insulin-dependent signaling factor. Overall, this work shows the key role of undernutrition during pregnancy as a cause of impaired glucose tolerance and increased diabetes risk in offspring. The findings of this study may inform preemptive measures to prevent the development of metabolic syndrome in offspring of undernourished mothers.
C1 [Takemori, Kumiko; Kometani, Takashi] Kindai Univ, Fac Agr, Dept Food Sci & Nutr, Nara, Japan.
   [Takemori, Kumiko; Yoshimoto, Kaito; Aoki, Kana; Kometani, Takashi] Kindai Univ, Grad Sch Agr Sci, Dept Appl Biol Chem, Nara, Japan.
   [Matsuo, Takuya] Kindai Univ, Fac Med, Dept Arts & Sci, Osaka, Japan.
   [Kometani, Takashi] Pharma Foods Int Co Ltd, Kyoto, Japan.
C3 Kindai University (Kinki University); Kindai University (Kinki
   University); Kindai University (Kinki University)
RP Takemori, K (corresponding author), Kindai Univ, Fac Agr, Dept Food Sci & Nutr, Nara, Japan.; Takemori, K (corresponding author), Kindai Univ, Grad Sch Agr Sci, Dept Appl Biol Chem, Nara, Japan.
EM kuriman@nara.kindai.ac.jp
CR [Anonymous], About Us
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NR 25
TC 0
Z9 0
U1 1
U2 7
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0916-8451
EI 1347-6947
J9 BIOSCI BIOTECH BIOCH
JI Biosci. Biotechnol. Biochem.
PD JUN 25
PY 2022
VL 86
IS 7
BP 875
EP 883
DI 10.1093/bbb/zbac053
EA APR 2022
PG 9
WC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
   Chemistry, Applied; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
   Chemistry; Food Science & Technology
GA 2J3CD
UT WOS:000808213200001
PM 35404447
OA Bronze
DA 2025-06-11
ER

PT J
AU Lteif, C
   Ataya, A
   Duarte, JD
AF Lteif, Christelle
   Ataya, Ali
   Duarte, Julio D.
TI Therapeutic Challenges and Emerging Treatment Targets for Pulmonary
   Hypertension in Left Heart Disease
SO JOURNAL OF THE AMERICAN HEART ASSOCIATION
LA English
DT Review
DE heart failure; mechanisms; pathophysiology; pulmonary hypertension;
   treatment
ID PRESERVED EJECTION FRACTION; SOLUBLE GUANYLATE-CYCLASE; LOOP-HELIX
   PROTEINS; ENDOTHELIN RECEPTOR ANTAGONISM; CAPILLARY WEDGE PRESSURE;
   DOUBLE-BLIND; ARTERIAL-HYPERTENSION; NITRIC-OXIDE; SEROTONIN
   TRANSPORTER; METABOLIC SYNDROME
AB Pulmonary hypertension (PH) attributable to left heart disease (LHD) is believed to be the most common form of PH and is strongly associated with increased mortality and morbidity in this patient population. Specific therapies for PH-LHD have not yet been identified and the use of pulmonary artery hypertension-targeted therapies in PH-LHD are not recommended. Endothelin receptor antagonists, phosphodiesterase-5 inhibitors, guanylate cyclase stimulators, and prostacyclins have all been studied in PH-LHD with conflicting results. Understanding the mechanisms underlying PH-LHD could potentially provide novel therapeutic targets. Fibrosis, oxidative stress, and metabolic syndrome have been proposed as pathophysiological components of PH-LHD. Genetic associations have also been identified, offering additional mechanisms with biological plausibility. This review summarizes the evidence and challenges for treatment of PH-LHD and focuses on underlying mechanisms on the horizon that could develop into potential therapeutic targets for this disease.
C1 [Lteif, Christelle; Duarte, Julio D.] Univ Florida, Coll Pharm, Dept Pharmacotherapy & Translat Res, Ctr Pharmacogen & Precis Med, Gainesville, FL USA.
   [Ataya, Ali] Univ Florida, Coll Med, Div Pulm Crit Care & Sleep Med, Gainesville, FL USA.
C3 State University System of Florida; University of Florida; State
   University System of Florida; University of Florida
RP Duarte, JD (corresponding author), Univ Florida, Coll Pharm, HSC POB 100486,1600 SW Archer Rd, Gainesville, FL 32610 USA.
EM juliod@cop.ufl.edu
OI Duarte, Julio/0000-0001-9766-4038; Lteif,
   Christelle/0000-0002-0468-8936; Ataya, Ali/0000-0001-8505-1680
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NR 146
TC 17
Z9 17
U1 0
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
EI 2047-9980
J9 J AM HEART ASSOC
JI J. Am. Heart Assoc.
PD JUN 1
PY 2021
VL 10
IS 11
AR e020633
DI 10.1161/JAHA.120.020633
PG 19
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA SK8OB
UT WOS:000656475800016
PM 34032129
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Barrera, M
   Hiriart, M
   Cocho, G
   Villarreal, C
AF Barrera, M.
   Hiriart, M.
   Cocho, G.
   Villarreal, C.
TI Type 2 diabetes progression: A regulatory network approach
SO CHAOS
LA English
DT Article
ID THIOREDOXIN-INTERACTING PROTEIN; BETA-CELL FAILURE; INSULIN-RESISTANCE;
   METABOLIC SYNDROME; MATHEMATICAL-MODEL; SIGNALING PATHWAYS; IONIC
   CHANNELS; CA2+ IONS; GLUCOSE; INFLAMMATION
AB In order to elucidate central elements underlying type 2 diabetes, we constructed a regulatory network model involving 37 components (molecules, receptors, processes, etc.) associated to signaling pathways of pancreatic beta-cells. In a first approximation, the network topology was described by Boolean rules whose interacting dynamics predicted stationary patterns broadly classified as health, metabolic syndrome, and diabetes stages. A subsequent approximation based on a continuous logic analysis allowed us to characterize the progression of the disease as transitions between these states associated to alterations of cell homeostasis due to exhaustion or exacerbation of specific regulatory signals. The method allowed the identification of key transcription factors involved in metabolic stress as essential for the progression of the disease. Integration of the present analysis with existent mathematical models designed to yield accurate account of experimental data in human or animal essays leads to reliable predictions for beta-cell mass, insulinemia, glycemia, and glycosylated hemoglobin in diabetic fatty rats.
C1 [Barrera, M.] Univ Nacl Autonoma Mexico, Inst Ecol, Mexico City 04510, DF, Mexico.
   [Hiriart, M.] Univ Nacl Autonoma Mexico, Inst Fisiol Celular, Mexico City 04510, DF, Mexico.
   [Cocho, G.; Villarreal, C.] Univ Nacl Autonoma Mexico, Inst Fis, Mexico City 04510, DF, Mexico.
   [Hiriart, M.; Cocho, G.; Villarreal, C.] Univ Nacl Autonoma Mexico, Ctr Ciencias Complejidad, Mexico City 04510, DF, Mexico.
C3 Universidad Nacional Autonoma de Mexico; Universidad Nacional Autonoma
   de Mexico; Universidad Nacional Autonoma de Mexico; Universidad Nacional
   Autonoma de Mexico
RP Villarreal, C (corresponding author), Univ Nacl Autonoma Mexico, Inst Fis, Mexico City 04510, DF, Mexico.
EM carlos@fisica.unam.mx
RI Villarreal, Carlos/D-7530-2016; Hiriart, Marcia/A-3988-2008
OI Villarreal, Carlos/0000-0003-3569-2820; Barrera,
   Maria/0000-0002-4232-6258; Hiriart, Marcia/0000-0001-5711-8868
FU CONACYT [379165]; Project CONACYT [180381]; Centro de Ciencias de la
   Complejidad, UNAM
FX M.B., M.H., and C.V. acknowledge the enormous intellectual influence and
   teachings of G. Cocho, co-author of this paper, who passed away during
   the elaboration of this work. We also acknowledge valuable comments of
   C. F. Bunge. M.B. is a Ph.D. student from Programa de Doctorado en
   Ciencias Biomedicas, Universidad Nacional Autonoma de Mexico (UNAM) and
   received Fellowship (No. 379165) from CONACYT. C.V. acknowledges
   financial support from Project CONACYT (No. 180381). All authors
   acknowledge support from Centro de Ciencias de la Complejidad, UNAM.
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NR 90
TC 3
Z9 3
U1 1
U2 5
PU AMER INST PHYSICS
PI MELVILLE
PA 1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USA
SN 1054-1500
EI 1089-7682
J9 CHAOS
JI Chaos
PD SEP
PY 2020
VL 30
IS 9
AR 093132
DI 10.1063/5.0011125
PG 13
WC Mathematics, Applied; Physics, Mathematical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Mathematics; Physics
GA NU8ZQ
UT WOS:000573926300005
PM 33003944
DA 2025-06-11
ER

PT J
AU Kolka, CM
   Bergman, RN
AF Kolka, Cathryn M.
   Bergman, Richard N.
TI The endothelium in diabetes: Its role in insulin access and diabetic
   complications
SO REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
LA English
DT Article
DE Diabetes; Endothelium; Insulin; Interstitium; Muscle; Vascular
ID ACTIVATED RECEPTOR-GAMMA; SKELETAL-MUSCLE; IN-VIVO; ADIPOSE-TISSUE;
   NITRIC-OXIDE; PHYSIOLOGICAL HYPERINSULINEMIA; GLOMERULAR ENDOTHELIUM;
   METABOLIC SYNDROME; OXIDATIVE STRESS; GLUCOSE-UPTAKE
AB The vascular endothelium has been identified as an important component in diabetes-associated complications, which include many cardiovascular disorders such as atherosclerosis, hypertension and peripheral neuropathy. Additionally, insulin's actions on the endothelium are now seen as a major factor in the metabolic effects of the hormone by increasing access to insulin sensitive tissues. Endothelial function is impaired in diabetes, obesity, and the metabolic syndrome, which could reduce insulin access to the tissue, and thus reduce insulin sensitivity independently of direct effects at the muscle cell. As such, the endothelium is a valid target for treatment of both the impaired glucose metabolism in diabetes, as well as the vascular based complications of diabetes. Here we review the basics of the endothelium in insulin action, with a focus on the skeletal muscle as insulin's major metabolic organ, and how this is affected by diabetes. We will focus on the most recent developments in the field, including current treatment possibilities.
C1 [Kolka, Cathryn M.; Bergman, Richard N.] Cedars Sinai Med Ctr, Dept Biomed Sci, Diabet & Obes Res Inst, Los Angeles, CA 90048 USA.
C3 Cedars Sinai Medical Center
RP Kolka, CM (corresponding author), Cedars Sinai Med Ctr, Dept Biomed Sci, Diabet & Obes Res Inst, 8700 Beverly Blvd,THAL E104, Los Angeles, CA 90048 USA.
EM Cathryn.Kolka@cshs.org
RI Bergman, Richard/B-9894-2013; Kolka, Cathryn/B-1526-2015
OI Kolka, Cathryn/0000-0002-6636-7062; Bergman, Richard/0000-0003-1539-4471
FU National Institutes of Health [DK27619, DK29867]
FX This work was supported by two National Institutes of Health grants,
   DK27619 and DK29867.
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TC 45
Z9 51
U1 0
U2 24
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1389-9155
EI 1573-2606
J9 REV ENDOCR METAB DIS
JI Rev. Endocr. Metab. Disord.
PD MAR
PY 2013
VL 14
IS 1
BP 13
EP 19
DI 10.1007/s11154-012-9233-5
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 098SC
UT WOS:000315568000003
PM 23306780
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Moreto, F
   de Oliveira, EP
   Manda, RM
   Burini, RC
AF Moreto, Fernando
   de Oliveira, Erick P.
   Manda, Rodrigo M.
   Burini, Roberto C.
TI The Higher Plasma Malondialdehyde Concentrations Are Determined by
   Metabolic Syndrome-Related Glucolipotoxicity
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Article
ID GAMMA-GLUTAMYL-TRANSFERASE; SUGAR-SWEETENED BEVERAGES;
   CARDIOVASCULAR-DISEASE; LIPID-PEROXIDATION; OXIDATIVE STRESS;
   ADIPOSE-TISSUE; OBESITY; BIOCHEMISTRY; CHEMISTRY; RISK
AB This study aimed to elucidate the determinants of higher plasma malondialdehyde (MDA) in free-living adults. In a cross-sectional study we evaluated 148 free-living subjects (54 +/- 11 years, 78% women) at high risk for or with metabolic syndrome (MetS). They were assessed by anthropometry and body composition, dietary intake, and clinical and laboratorial analysis. The analysis of plasma MDA was performed by HPLC, and concentration values were used to provide four groups according to percentile distribution. Subjects with higher plasma MDA showed higher prevalence of MetS and higher values of waist circumference (WC), glucose, triglycerides (TG), gamma-glutamyltransferase (gamma-GT), and higher energy intake. Multiadjusted logistic regression analysis identified as determinants of higher plasma MDA the altered values of WC and gamma-GT followed by hypertriglyceridemia, hyperglycemia, insulin resistance, higher dietary sugar-intake, and presence of MetS. In conclusion, the glucolipotoxic state predisposed by the presence of MetS seems to be the major determinant of higher plasma MDA concentrations.
C1 [Moreto, Fernando; de Oliveira, Erick P.; Manda, Rodrigo M.; Burini, Roberto C.] Sao Paulo State Univ, Botucatu Sch Med, Ctr Nutr & Exercise Metab CeMENutri, Botucatu, SP, Brazil.
   [de Oliveira, Erick P.] Univ Fed Uberlandia, Sch Med, BR-38400 Uberlandia, MG, Brazil.
C3 Universidade Estadual Paulista; Universidade Federal de Uberlandia
RP Moreto, F (corresponding author), Sao Paulo State Univ, Botucatu Sch Med, Ctr Nutr & Exercise Metab CeMENutri, Botucatu, SP, Brazil.
EM fer_moreto@yahoo.com.br
RI de Oliveira, Erick/D-1138-2011; Moreto, Fernando/I-7690-2013
OI Moreto, Fernando/0000-0002-4028-0014; P. de Oliveira,
   Erick/0000-0001-8989-8344
FU CAPES; CNPq
FX The authors thank CAPES and CNPq for the financial support.
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NR 34
TC 32
Z9 34
U1 0
U2 3
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PY 2014
VL 2014
AR 505368
DI 10.1155/2014/505368
PG 7
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA AK6QF
UT WOS:000338551500001
PM 25089170
OA Green Published, hybrid, Green Submitted
DA 2025-06-11
ER

PT J
AU Walvoord, EC
AF Walvoord, Emily C.
TI The Timing of Puberty: Is It Changing? Does It Matter?
SO JOURNAL OF ADOLESCENT HEALTH
LA English
DT Review
DE Puberty; Endocrine disrupting chemicals; Obesity; Secular trend;
   Menarche; breast cancer; Metabolic syndrome; Pubertal onset; Testicular
   cancer; Children; Age of puberty
ID BODY-MASS INDEX; SECONDARY SEX CHARACTERISTICS;
   HEALTH-EXAMINATION-SURVEY; OVARIAN-CANCER RISK; UNITED-STATES;
   BREAST-CANCER; TESTICULAR CANCER; MENARCHEAL AGE; SECULAR TRENDS;
   BOGALUSA HEART
AB Whether the secular trend of a decreasing age of puberty has continued over the past 50 years remains controversial. Data that had been classically used to address this issue are reviewed and large epidemiologic studies, which had not previously been included, are now considered to challenge the conclusions of prior debates of this topic. The effect and timing of excessive weight gain are discussed in detail and recent observations about the opposing effects of obesity on the pubertal timing of girls versus boys are considered. The second half of the review examines both the causes and the long-term health consequences of early puberty, touching on the possible effect of stress and endocrine-disrupting chemicals along with the risks of reproductive cancers, metabolic syndrome, and psychosocial consequences during adolescence and beyond. (C) 2010 Society for Adolescent Health and Medicine. All rights reserved.
C1 Indiana Univ Sch Med, Dept Pediat, Sect Endocrinol & Diabetol, Indianapolis, IN 46202 USA.
C3 Indiana University System; Indiana University Bloomington
RP Walvoord, EC (corresponding author), Indiana Univ Sch Med, Dept Pediat, Sect Endocrinol & Diabetol, 702 Barnhill Dr,Room 5960, Indianapolis, IN 46202 USA.
EM ewalvoor@iupui.edu
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NR 89
TC 149
Z9 170
U1 1
U2 36
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1054-139X
J9 J ADOLESCENT HEALTH
JI J. Adolesc. Health
PD NOV
PY 2010
VL 47
IS 5
BP 433
EP 439
DI 10.1016/j.jadohealth.2010.05.018
PG 7
WC Psychology, Developmental; Public, Environmental & Occupational Health;
   Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Public, Environmental & Occupational Health; Pediatrics
GA 668IY
UT WOS:000283263100004
PM 20970077
DA 2025-06-11
ER

PT J
AU Mikkelsen, ACD
   Kjærgaard, K
   Mookerjee, RP
   Vilstrup, H
   Wegener, G
   Bay-Richter, C
   Thomsen, KL
AF Mikkelsen, Anne Catrine Daugaard
   Kjaergaard, Kristoffer
   Mookerjee, Rajeshwar Prosad
   Vilstrup, Hendrik
   Wegener, Gregers
   Bay-Richter, Cecilie
   Thomsen, Karen Louise
TI Non-alcoholic Fatty Liver Disease: Also a Disease of the Brain? A
   Systematic Review of the Preclinical Evidence
SO NEUROCHEMICAL RESEARCH
LA English
DT Review
DE Non-alcoholic fatty liver disease; Neuroinflammation; Neurodegeneration;
   Neurotransmitters; Oxidative stress; Synaptic density
ID MILD COGNITIVE IMPAIRMENT; MIDDLE-AGED ADULTS; TLR4 UP-REGULATION;
   METABOLIC SYNDROME; ALZHEIMERS-DISEASE; INSULIN-RESISTANCE; GUT
   MICROBIOTA; INFLAMMATION; DEPRESSION; ASSOCIATION
AB Non-alcoholic fatty liver disease (NAFLD) currently affects 25% of the global adult population. Cognitive impairment is a recently recognised comorbidity impeding memory, attention, and concentration, affecting the patients' activities of daily living and reducing their quality of life. This systematic review provides an overview of the evidence for, and potential pathophysiological mechanisms behind brain dysfunction at a neurobiological level, in preclinical NAFLD. We performed a systematic literature search for animal models of NAFLD studying intracerebral conditions using PubMed, Embase and Scopus. We included studies that reported data on neurobiology in rodent and pig models with evidence of steatosis or steatohepatitis assessed by liver histology. 534 unique studies were identified, and 30 studies met the selection criteria, and were included. Findings of neurobiological changes were divided into five key areas: (1) neuroinflammation, (2) neurodegeneration, (3) neurotransmitter alterations, (4) oxidative stress, and (5) changes in proteins and synaptic density. Despite significant heterogeneity in the study designs, all but one study of preclinical NAFLD reported changes in one or more of the above key areas when compared to control animals. In conclusion, this systematic review supports an association between all stages of NAFLD (from simple steatosis to non-alcoholic steatohepatitis (NASH)) and neurobiological changes in preclinical models.
C1 [Mikkelsen, Anne Catrine Daugaard; Kjaergaard, Kristoffer; Mookerjee, Rajeshwar Prosad; Vilstrup, Hendrik; Thomsen, Karen Louise] Aarhus Univ Hosp, Dept Hepatol & Gastroenterol, Aarhus N, Denmark.
   [Mookerjee, Rajeshwar Prosad; Thomsen, Karen Louise] UCL, UCL Inst Liver & Digest Hlth, London, England.
   [Wegener, Gregers; Bay-Richter, Cecilie] Aarhus Univ, Dept Clin Med, Translat Neuropsychiat Unit, Aarhus C, Denmark.
C3 Aarhus University; University of London; University College London;
   Aarhus University
RP Mikkelsen, ACD (corresponding author), Aarhus Univ Hosp, Dept Hepatol & Gastroenterol, Aarhus N, Denmark.
EM ancami@clin.au.dk
RI Bay-Richter, Cecilie/AAX-2712-2020; KjÃ¦rgaard,
   Kristoffer/ADU-5541-2022; Wegener, Gregers/A-1019-2011
OI Bay-Richter, Cecilie/0000-0002-2254-4020; Daugaard Mikkelsen, Anne
   Catrine/0000-0002-7882-1816; Kjaergaard, Kristoffer/0000-0002-6440-2784;
   Thomsen, Karen Louise/0000-0002-8118-4643; Mookerjee, Rajeshwar
   Prosad/0000-0002-6275-9384; Wegener, Gregers/0000-0002-0081-0068
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NR 89
TC 9
Z9 9
U1 1
U2 37
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0364-3190
EI 1573-6903
J9 NEUROCHEM RES
JI Neurochem. Res.
PD JUN
PY 2024
VL 49
IS 6
SI SI
BP 1468
EP 1488
DI 10.1007/s11064-022-03551-x
EA MAR 2022
PG 21
WC Biochemistry & Molecular Biology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Neurosciences & Neurology
GA RM0T7
UT WOS:000762891100002
PM 35230646
DA 2025-06-11
ER

PT J
AU Suetani, S
   Mamun, A
   Williams, GM
   Najman, JM
   McGrath, JJ
   Scott, JG
AF Suetani, S.
   Mamun, A.
   Williams, G. M.
   Najman, J. M.
   McGrath, J. J.
   Scott, J. G.
TI The association between adolescent psychopathology and subsequent
   physical activity in young adulthood: a 21-year birth cohort study
SO PSYCHOLOGICAL MEDICINE
LA English
DT Article
DE Longitudinal study; physical activity; psychopathology
ID CARDIOMETABOLIC RISK-FACTORS; MAJOR DEPRESSIVE DISORDER; MENTAL-HEALTH
   SURVEY; AGE-OF-ONSET; CARDIORESPIRATORY FITNESS; MATER-UNIVERSITY; LIFE
   EXPECTANCY; PREGNANCY MUSP; METAANALYSIS; EXERCISE
AB Background. The beneficial effects of physical activity (PA) for both physical and mental wellbeing are well established. Given that adolescence presents a critical developmental period during which life-long patterns of PA become established, the exploration of the longitudinal impact of adolescent psychopathology on adult PA status is of interest.
   Methods. We analysed prospective data from 3663 young adults who participated in the Mater-University of Queensland Study of Pregnancy. Psychopathology was measured using the Youth Self-Report (YSR) at age 14. Participants' engagement in three types of PA (vigorous exercise, moderate exercise and walking) at age 21 were dichotomised into either 'none' or 'any'. For our main analysis, we examined the association between the YSR score and subsequent PA engagement using logistic regression. We also conducted sensitivity analyses of longitudinal associations between the YSR internalising and externalising symptoms score at age 14 and PA engagement at age 21.
   Results. We found no longitudinal association between the total YSR score at age 14 and PA engagement at age 21. In addition, there was no longitudinal association between the YSR internalising or externalising symptoms and PA engagement.
   Conclusion. Our findings suggest that there is no longitudinal association between adolescent psychopathology and PA in young adulthood.
C1 [Suetani, S.; McGrath, J. J.; Scott, J. G.] Pk Ctr Mental Hlth, Queensland Ctr Mental Hlth Res, Wacol, Qld 4076, Australia.
   [Suetani, S.; McGrath, J. J.] Univ Queensland, Queensland Brain Inst, St Lucia, Qld, Australia.
   [Suetani, S.] Metro South Addict & Mental Hlth Serv, Brisbane, Qld, Australia.
   [Mamun, A.] Univ Queensland, Inst Social Sci Res, Indooroopilly, Qld, Australia.
   [Williams, G. M.; Najman, J. M.] Univ Queensland, Sch Populat Hlth, Herston, Qld, Australia.
   [Najman, J. M.] Univ Queensland, Sch Social Sci, St Lucia, Qld, Australia.
   [McGrath, J. J.] Aarhus Univ, Natl Ctr Register Based Res, Aarhus C, Denmark.
   [Scott, J. G.] Univ Queensland, Ctr Clin Res, Herston, Qld, Australia.
   [Scott, J. G.] Royal Brisbane & Womens Hosp, Metro North Mental Hlth, Herston, Qld, Australia.
C3 Queensland Centre for Mental Health Research; University of Queensland;
   University of Queensland; University of Queensland; University of
   Queensland; Aarhus University; University of Queensland; Royal Brisbane
   & Women's Hospital
RP Suetani, S (corresponding author), Pk Ctr Mental Hlth, Queensland Ctr Mental Hlth Res, Wacol, Qld 4076, Australia.
EM shuichi.suetani@health.qld.gov.au
RI Williams, Gail/S-8833-2019; Mamun, Abdullah/HHM-9898-2022; Najman,
   Jackob/B-1527-2008; McGrath, John/G-5493-2010; Scott, James/D-5900-2012;
   Mamun, Abdullah/A-4673-2011
OI Najman, Jackob/0000-0001-7079-2080; McGrath, John/0000-0002-4792-6068;
   Scott, James/0000-0002-0744-0688; Williams, Gail/0000-0002-4822-5263;
   Suetani, Shuichi/0000-0002-2487-5691; Mamun,
   Abdullah/0000-0002-1535-8086
FU National Health and Medical Research Council (NHMRC) [1009460]; National
   Health and Medical Research Council Practitioner Fellowship [1105807];
   National Health and Medical Research Council [APP1056929]
FX The MUSP is funded by the National Health and Medical Research Council
   (NHMRC grant no. 1009460). J. G Scott is supported by a National Health
   and Medical Research Council Practitioner Fellowship Grant no. 1105807.
   J. J. McGrath received John Cade Fellowship APP1056929 from the National
   Health and Medical Research Council.
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NR 45
TC 7
Z9 7
U1 0
U2 10
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
SN 0033-2917
EI 1469-8978
J9 PSYCHOL MED
JI Psychol. Med.
PD JAN
PY 2018
VL 48
IS 2
BP 269
EP 278
DI 10.1017/S0033291717001660
PG 10
WC Psychology, Clinical; Psychiatry; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA FR0GV
UT WOS:000418740300009
PM 28625171
DA 2025-06-11
ER

PT J
AU Maneschi, E
   Cellai, I
   Aversa, A
   Mello, T
   Filippi, S
   Comeglio, P
   Bani, D
   Guasti, D
   Sarchielli, E
   Salvatore, G
   Morelli, A
   Mazzanti, B
   Corcetto, F
   Corno, C
   Francomano, D
   Galli, A
   Vannelli, GB
   Lenzi, A
   Mannucci, E
   Maggi, M
   Vignozzi, L
AF Maneschi, Elena
   Cellai, Ilaria
   Aversa, Antonio
   Mello, Tommaso
   Filippi, Sandra
   Comeglio, Paolo
   Bani, Daniele
   Guasti, Daniele
   Sarchielli, Erica
   Salvatore, Giulia
   Morelli, Annamaria
   Mazzanti, Benedetta
   Corcetto, Francesca
   Corno, Chiara
   Francomano, Davide
   Galli, Andrea
   Vannelli, Gabriella Barbara
   Lenzi, Andrea
   Mannucci, Edoardo
   Maggi, Mario
   Vignozzi, Linda
TI Tadalafil reduces visceral adipose tissue accumulation by promoting
   preadipocytes differentiation towards a metabolically healthy phenotype:
   Studies in rabbits
SO MOLECULAR AND CELLULAR ENDOCRINOLOGY
LA English
DT Article
DE Metabolic syndrome; Tadalafil; PDE5; Insulin-resistance
ID INDUCED ERECTILE DYSFUNCTION; BROWN-FAT; SKELETAL-MUSCLE; MITOCHONDRIAL
   DYSFUNCTION; PROSTATE ALTERATIONS; THERMOGENIC PROGRAM; BLADDER
   ALTERATIONS; OXIDATIVE STRESS; GENE-EXPRESSION; PDE5 INHIBITORS
AB Development of metabolically healthy adipocytes within dysfunctional adipose tissue may represent an attractive way to counteract metabolic syndrome (MetS). In an experimental animal model of high fat diet (HFD)-induced MetS, in vivo, long- and short-term tadalafil treatments were able to reduce visceral adipose tissue (VAT) accumulation and hypertriglyceridemia, and to induce the expression in VAT of the brown fat-specific marker, uncoupling protein 1 (UCP1). VAT preadipocytes (PAD), isolated from the tadalafil-treated HFD rabbits, showed: i) a multilocular morphology; ii) an increased expression of brown fat-specific genes (such as UCP1 and CIDEA); iii) improved mitochondrial structure and dynamic and reduced superoxide production; iv) improved insulin sensitivity. Similar effects were obtained after in vitro tadalafil treatment in HFD rPAD. In conclusion, tadalafil counteracted HFD-associated VAT alterations, by restoring insulin-sensitivity and prompting preadipocytes differentiation towards a metabolically healthy phenotype. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
C1 [Maneschi, Elena; Cellai, Ilaria; Comeglio, Paolo; Salvatore, Giulia; Corcetto, Francesca; Corno, Chiara; Maggi, Mario; Vignozzi, Linda] Univ Florence, Dept Expt & Clin Biomed Sci, Sexual Med & Androl Unit, Viale Morgagni 50, I-50134 Florence, Italy.
   [Aversa, Antonio; Francomano, Davide; Lenzi, Andrea] Univ Roma La Sapienza, Food Sci & Endocrinol Sect, Med Pathophysiol, Dept Expt Med, Viale Regina Elena 324, I-00161 Rome, Italy.
   [Mello, Tommaso; Galli, Andrea] Univ Florence, Dept Expt & Clin Biomed Sci, Gastroenterol Unit, I-50134 Florence, Italy.
   [Filippi, Sandra] Univ Florence, Dept Neurosci Drug Res & Child Care, Interdept Lab Funct & Cellular Pharmacol Reprod, Pieraccini 6, I-50139 Florence, Italy.
   [Bani, Daniele; Guasti, Daniele; Sarchielli, Erica; Morelli, Annamaria; Mazzanti, Benedetta; Vannelli, Gabriella Barbara] Univ Florence, Dept Expt & Clin Med, Largo Brambilla 3, I-50134 Florence, Italy.
   [Mannucci, Edoardo] Careggi Hosp, Dept Crit Care, Diabet Sect Geriatr Unit, Largo Brambilla 3, I-50134 Florence, Italy.
C3 University of Florence; Sapienza University Rome; University of
   Florence; University of Florence; University of Florence; University of
   Florence; Azienda Ospedaliero Universitaria Careggi
RP Vignozzi, L (corresponding author), Univ Florence, Gynaecol Endocrinol Unit, Dept Expt & Clin Biomed Sci, Viale Pieraccini 6, I-50139 Florence, Italy.
EM linda.vignozzi@unifi.it
RI Aversa, Antonio/O-3151-2019; Morelli, Annamaria/AAS-4244-2020; Maggi,
   Mario/AAB-8284-2019; Galli, Andrea/AAC-1623-2019; Bani,
   Daniele/AAC-7234-2021; Mello, Tommaso/I-4715-2012; Mannucci,
   Edoardo/K-6749-2016
OI MAGGI, Mario/0000-0003-3267-4221; Vignozzi, Linda/0000-0003-0907-0630;
   DANIELE, GUASTI/0000-0002-2856-6829; Mello, Tommaso/0000-0002-6192-6902;
   Salvatore, Giulia/0000-0003-3573-9254; CORNO,
   CHIARA/0000-0002-0012-6522; Mannucci, Edoardo/0000-0001-9759-9408;
   Galli, Andrea/0000-0001-5416-6290
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NR 73
TC 22
Z9 23
U1 0
U2 8
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0303-7207
J9 MOL CELL ENDOCRINOL
JI Mol. Cell. Endocrinol.
PD MAR 15
PY 2016
VL 424
IS C
BP 50
EP 70
DI 10.1016/j.mce.2016.01.015
PG 21
WC Cell Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Endocrinology & Metabolism
GA DH3GJ
UT WOS:000372675200006
PM 26805634
DA 2025-06-11
ER

PT J
AU Marotta, F
   Kumari, A
   Catanzaro, R
   Solimene, U
   Jain, S
   Minelli, E
   Harada, M
AF Marotta, Francesco
   Kumari, Archana
   Catanzaro, Roberto
   Solimene, Umberto
   Jain, Shalini
   Minelli, Emilio
   Harada, Masatoshi
TI A Phytochemical Approach to Experimental Metabolic Syndrome-Associated
   Renal Damage and Oxidative Stress
SO REJUVENATION RESEARCH
LA English
DT Article
ID CARDIOVASCULAR-DISEASE; KIDNEY-DISEASE; FRUCTOSE; HYPERTENSION;
   NOTOGINSENG; MORTALITY; EXTRACTS
AB The aim of this study was to evaluate the effect of DTS-phytocompound on oxidant-antioxidant balance and protein damage in the kidneys of rats administered high doses of fructose. Adult male Wistar rats were divided into four groups. Group A received a control diet, whereas groups B and C were fed a high-fructose diet (60 g/100 g), the latter with additional DTS (50 mg/kg per day) for 60 days. Lipo-and nitro-peroxidation together with alpha-smooth muscle actin (alpha-SMA) expression in the glomerular and interstitial tissue of the kidneys were measured after 60 days. Fructose-fed rats showed significantly higher lipoperoxidation, 2,4-dinitrophenol and 3-nitrotyrosine protein adducts, and upregulation of alpha-SMA in the kidney. DTS significantly decreased such redox unbalance in renal tissue, while partially downregulating alpha-SMA (p < 0.01). These data suggest the potential clinical benefit of DTS in protecting the kidneys from metabolic syndrome-associated changes; gender-related analysis is under way.
C1 [Marotta, Francesco] ReGenera Res Grp Aging Intervent, I-20154 Milan, Italy.
   [Kumari, Archana] Univ Quebec, Inst Natl Rech Sci, Ctr Eau Terre & Environm, Quebec City, PQ, Canada.
   [Catanzaro, Roberto] Univ Catania, Dept Internal Med, Gastroenterol Unit, Catania, Italy.
   [Solimene, Umberto; Minelli, Emilio] Univ Milan, WHO Ctr Biotechnol & Tradit Med, Milan, Italy.
   [Jain, Shalini] NIDDK, NIH, Bethesda, MD USA.
   [Harada, Masatoshi] MCH Hosp, Saitama, Japan.
C3 University of Quebec; Institut national de la recherche scientifique
   (INRS); University of Catania; University of Milan; National Institutes
   of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive &
   Kidney Diseases (NIDDK)
RP Marotta, F (corresponding author), ReGenera Res Grp Aging Intervent, Piazza Firenze 12, I-20154 Milan, Italy.
EM fmarchimede@libero.it
RI Marotta, Francesco/ABI-1960-2020; CATANZARO, Roberto/ABE-8085-2020
OI CATANZARO, Roberto/0000-0003-4852-9125; Marotta,
   Francesco/0000-0002-6016-1864
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NR 21
TC 1
Z9 1
U1 0
U2 4
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1549-1684
EI 1557-8577
J9 REJUV RES
JI Rejuv. Res.
PD APR
PY 2012
VL 15
IS 2
BP 153
EP 156
DI 10.1089/rej.2011.1266
PG 4
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA 933SS
UT WOS:000303383600010
PM 22533421
DA 2025-06-11
ER

PT J
AU Szczepanska, E
   Janota, B
   Wlazlo, M
   Gacal, M
AF Szczepanska, Elzbieta
   Janota, Barbara
   Wlazlo, Marika
   Gacal, Magdalena
TI Can Daily Dietary Choices Have a Cardioprotective Effect? Food Compounds
   in the Prevention and Treatment of Cardiometabolic Diseases
SO METABOLITES
LA English
DT Review
DE metabolic syndrome; cardiovascular disease; diet; nutrients; food
ID POLYUNSATURATED FATTY-ACIDS; CARDIOVASCULAR-DISEASE; BLOOD-PRESSURE;
   FIBER INTAKE; VITAMIN-C; HEALTH; SUPPLEMENTATION; STRESS; IMPACT
AB Cardiovascular diseases accompanying metabolic syndrome comprise one of the leading causes of death worldwide. The medical community undertakes attempts to improve treatment options and minimize cardiovascular diseases' numerous consequences and exacerbations. In parallel with pharmacotherapies provided by physicians, nutritionists are developing strategies for diet therapy and prevention based on lifestyle changes, with high success rates. Consumption of specified food compounds included in various products with proven protective properties can be helpful in this regard. Due to the wide possibilities of diet in metabolic health promotion, it seems necessary to systematize information about the metabolically protective and cardioprotective properties of fiber, probiotic bacteria, plant sterols, folic acid, vitamins B12, C, and E, PUFAs, lycopene, polyphenols, arginine, CoQ10, and allicin. The aim of this review was to present the food compounds with potential use in cardiometabolic prevention and diet therapy based on the latest available literature.
C1 [Szczepanska, Elzbieta] Med Univ Silesia, Fac Publ Hlth Bytom, Dept Human Nutr, Dept Dietet, Jordana 19 St, PL-41808 Zabrze, Poland.
   [Janota, Barbara] Med Univ Silesia, Fac Publ Hlth Bytom, Doctoral Sch, Dept Basic Med Sci, Piekarska 18 St, PL-41902 Bytom, Poland.
   [Wlazlo, Marika; Gacal, Magdalena] Med Univ Silesia, Fac Publ Hlth Bytom, Doctoral Sch, Piekarska 18 St, PL-41902 Bytom, Poland.
C3 Medical University of Silesia; Medical University of Silesia; Medical
   University of Silesia
RP Janota, B (corresponding author), Med Univ Silesia, Fac Publ Hlth Bytom, Doctoral Sch, Dept Basic Med Sci, Piekarska 18 St, PL-41902 Bytom, Poland.
EM d201083@365.sum.edu.pl
OI Wlazlo, Marika/0000-0003-0476-3585; Szczepanska,
   Elzbieta/0000-0001-9683-8999
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NR 113
TC 0
Z9 0
U1 2
U2 3
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2218-1989
J9 METABOLITES
JI Metabolites
PD JUN
PY 2024
VL 14
IS 6
AR 296
DI 10.3390/metabo14060296
PG 16
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA WR8X0
UT WOS:001256703100001
PM 38921431
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Sharma, P
   Mittal, P
   Arya, GC
AF Sharma, Priyanshu
   Mittal, Payal
   Arya, Girish Chandra
TI Unraveling the Mysteries of PCOS: A Comprehensive Investigation into
   Causes, Mechanisms, and Molecular Docking Analysis with Dolichos
   biflorus Linn.
SO CURRENT ANALYTICAL CHEMISTRY
LA English
DT Review; Early Access
DE PCOS; hyperinsulinemia; hyperandrogenism; genetic factors; etiology;
   molecular docking; binding energy
ID POLYCYSTIC-OVARY-SYNDROME; METABOLIC SYNDROME; HYPERANDROGENISM;
   DYSLIPIDEMIA; OBESITY; GROWTH; WOMEN; PATHOGENESIS; PREVALENCE;
   MANAGEMENT
AB Polycystic ovary syndrome (PCOS) presents as a complex endocrine and metabolic disorder characterized by anovulation, infertility, obesity, insulin resistance, and polycystic ovaries. Various factors contribute to PCOS risk, including lifestyle choices, diet, environmental pollutants, genetics, gut dysbiosis, neuroendocrine changes, and obesity. These factors can impact hyperinsulinemia, oxidative stress, hyperandrogenism, decreased folliculogenesis, and irregular menstrual cycles, ultimately contributing to metabolic syndrome. Conventional treatments for PCOS often carry significant side effects, prompting exploration into Ayurvedic alternatives. This review concentrates on molecular docking studies of phytochemicals sourced from Dolichos Biflorus Linn. against key proteins implicated in PCOS pathogenesis. Identification, modeling, and evaluation of target proteins were conducted, followed by the assessment of their interactions with selected phytochemicals and additional ADMET analysis. Molecular docking studies utilizing Auto Dock Vina software were then performed to forecast the binding affinities of these phytochemicals to the active sites of the specified targets.
C1 [Sharma, Priyanshu; Mittal, Payal; Arya, Girish Chandra] Chandigarh Univ, Dept Pharm, Mohali, India.
C3 Chandigarh University
RP Mittal, P (corresponding author), Chandigarh Univ, Dept Pharm, Mohali, India.
EM Payal.talk2@gmail.com
RI Arya, Girish chandra/ITV-3531-2023
OI Sharma, Priyanshu/0000-0001-6576-4544
FX The encouragement and inspiration to write the review that Chandigarh
   University gave the authors is greatly appreciated.
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NR 100
TC 0
Z9 0
U1 2
U2 7
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1573-4110
EI 1875-6727
J9 CURR ANAL CHEM
JI Curr. Anal. Chem.
PD 2024 SEP 12
PY 2024
DI 10.2174/0115734110312022240903060337
EA SEP 2024
PG 28
WC Chemistry, Analytical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry
GA F9C7B
UT WOS:001312715000001
DA 2025-06-11
ER

PT J
AU Nna, VU
   McGrowder, D
   Nwokocha, C
AF Nna, Victor Udo
   McGrowder, Donovan
   Nwokocha, Chukwuemeka
TI Nutraceutical management of metabolic syndrome as a palliative and a
   therapeutic to coronavirus disease (COVID) crisis
SO ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
LA English
DT Review
DE Metabolic syndrome; coronavirus; obesity; hypertension; diabetes
ID TYPE-2 DIABETES-MELLITUS; VERNONIA-AMYGDALINA; DOUBLE-BLIND; PROPOLIS
   EXTRACT; AQUEOUS EXTRACTS; GONGRONEMA LATIFOLIUM; CHEMICAL-COMPOSITION;
   ETHANOLIC EXTRACT; OXIDATIVE STRESS; ALOE-VERA
AB The global market for medicinal plants and herbs is on the increase due to their desirability, efficacy, and less adverse effects as complementary and alternative medications to the orthodox pharmaceuticals, perhaps due to their natural components and qualities. Metabolic syndromes are managed with changes in diet, exercise, lifestyle modifications and the use of pharmacological agents. Plants are now known to have potent antioxidant and cholinergic activities which are relevant to the management of several metabolic syndromes, which are unfortunately, co-morbidity factors in the coronavirus disease crisis. This review will focus on the biological activities of some plant products used as complementary and alternative medicines in the management of metabolic syndromes, and on their reported antiviral, antithrombotic, angiotensin-converting enzyme inhibitory properties, which are integral to their usage in the management of viral infections and may give an avenue for prophylactic and therapeutics especially in the absence of vaccines/formulated antiviral therapies.
C1 [Nna, Victor Udo] Univ Calabar, Coll Med Sci, Dept Physiol, PMB 1115, Calabar, Cross River Sta, Nigeria.
   [McGrowder, Donovan] Univ West Indies, Dept Pathol, Mona, Jamaica.
   [Nwokocha, Chukwuemeka] Univ West Indies, Physiol Sect, Dept Basic Med Sci, Kingston 7, Mona, Jamaica.
C3 University of Calabar; University West Indies Mona Jamaica; University
   West Indies Mona Jamaica
RP Nna, VU (corresponding author), Univ Calabar, Coll Med Sci, Dept Physiol, PMB 1115, Calabar, Cross River Sta, Nigeria.; Nwokocha, C (corresponding author), Univ West Indies, Physiol Sect, Dept Basic Med Sci, Kingston 7, Mona, Jamaica.
EM victorudon@unical.edu.ng; chukwuemeka.nwokocha@uwimona.edu.jm
RI McGrowder, Donovan/AAT-1538-2021; Nna, Victor/D-8197-2015
OI Nna, Victor/0000-0001-7616-9468; Nwokocha,
   Chukwuemeka/0000-0001-7092-9382
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NR 226
TC 7
Z9 7
U1 1
U2 8
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1381-3455
EI 1744-4160
J9 ARCH PHYSIOL BIOCHEM
JI Arch. Physiol. Biochem.
PD SEP 3
PY 2023
VL 129
IS 5
BP 1123
EP 1142
DI 10.1080/13813455.2021.1903041
EA MAR 2021
PG 20
WC Biochemistry & Molecular Biology; Biophysics; Endocrinology &
   Metabolism; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Endocrinology &
   Metabolism; Physiology
GA S1DT2
UT WOS:000633235500001
PM 33770443
DA 2025-06-11
ER

PT J
AU Zhang, ZG
   Zhou, SS
   Jiang, X
   Wang, YH
   Li, FS
   Wang, YG
   Zheng, Y
   Cai, L
AF Zhang, Zhiguo
   Zhou, Shanshan
   Jiang, Xin
   Wang, Yue-Hui
   Li, Fengsheng
   Wang, Yong-Gang
   Zheng, Yang
   Cai, Lu
TI The role of the Nrf2/Keap1 pathway in obesity and metabolic syndrome
SO REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
LA English
DT Article
DE Nrf2/Keap1; Metabolic homeostasis; Obesity; Insulin resistance; Reactive
   oxygen species
ID DEPENDENT HEPATIC LIPOGENESIS; DIET-INDUCED OBESITY; GROWTH-FACTOR 21;
   OXIDATIVE STRESS; INSULIN-RESISTANCE; LIPID-ACCUMULATION;
   ADIPOSE-TISSUE; MITOCHONDRIAL-FUNCTION; MOLECULAR-MECHANISMS; NRF2
   DEFICIENCY
AB Nuclear factor erythroid 2 related factor 2 (Nrf2) is a key regulator of antioxidant signaling that may prevent the development of metabolic syndrome and related cardiovascular diseases. However, emerging evidence shows that lack of Nrf2 could ameliorate insulin resistance, adipogenesis and adipocyte differentiation. Consistent with this, overexpression of Nrf2 gene could also cause insulin resistance under certain conditions. Furthermore, an increasing number of studies indicate that redox balance can be a critical element that contributes to the contradictory effects of Nrf2 on insulin sensitivity and resistance. Reactive oxygen species can promote normal insulin-mediated signal transduction under physiological conditions but also induce insulin resistance under certain pathological conditions. Therefore, the contradictory effects of Nrf2 on insulin signaling pathways may be related to its regulation of redox homeostasis. This review attempts to summarize the latest developments in our understanding of the mechanisms of Nrf2-mediated signaling and its role in the modulation of metabolic homeostasis.
C1 [Zhang, Zhiguo; Zhou, Shanshan; Jiang, Xin; Wang, Yue-Hui; Wang, Yong-Gang; Zheng, Yang] Jilin Univ, Hosp 1, Dept Cardiovasc Disorders, Changchun 130021, Peoples R China.
   [Zhang, Zhiguo; Zhou, Shanshan; Jiang, Xin; Wang, Yue-Hui; Wang, Yong-Gang; Zheng, Yang] Jilin Univ, Hosp 1, Dept Gerontol, Changchun 130021, Peoples R China.
   [Zhang, Zhiguo; Zhou, Shanshan; Jiang, Xin; Wang, Yue-Hui; Wang, Yong-Gang; Zheng, Yang] Jilin Univ, Hosp 1, Dept Radiat Oncol, Changchun 130021, Peoples R China.
   [Zhang, Zhiguo; Zhou, Shanshan; Jiang, Xin; Li, Fengsheng; Wang, Yong-Gang; Cai, Lu] Univ Louisville, Dept Pediat, Kosair Children Hosp Res Inst, Louisville, KY 40202 USA.
   [Li, Fengsheng] Second Artillery Gen Hosp, Beijing 100088, Peoples R China.
C3 Jilin University; Jilin University; Jilin University; University of
   Louisville
RP Zheng, Y (corresponding author), Jilin Univ, Hosp 1, Dept Cardiovasc Disorders, Changchun 130021, Peoples R China.
EM zhengyang@jlu.edu.cn; l0cai001@louisville.edu
RI Cai, Lu/AAG-9920-2019; Jiang, Xin/AHA-9454-2022
OI Jiang, Xin/0000-0002-4613-7438
FU National Natural Science Foundation of China [81370318, 81270293,
   81400281]; American Diabetes Association [1-11-BA-17, 7-14-BS-18]
FX Cited studies from the authors' laboratories were supported in part by
   the grants from the National Natural Science Foundation of China (No.
   81370318, to ZY; No. 81270293, to YHW; No. 81400281, to S.Z) and the
   American Diabetes Association (1-11-BA-17 & 7-14-BS-18, to LC).
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NR 91
TC 93
Z9 101
U1 1
U2 39
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1389-9155
EI 1573-2606
J9 REV ENDOCR METAB DIS
JI Rev. Endocr. Metab. Disord.
PD MAR
PY 2015
VL 16
IS 1
BP 35
EP 45
DI 10.1007/s11154-014-9305-9
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA CC6RD
UT WOS:000350493800004
PM 25540093
DA 2025-06-11
ER

PT J
AU Afrin, S
   Gasparrini, M
   Forbes-Hernandez, TY
   Reboredo-Rodriguez, P
   Mezzetti, B
   Varela-López, A
   Giampieri, F
   Battino, M
AF Afrin, Sadia
   Gasparrini, Massimiliano
   Forbes-Hernandez, Tamara Y.
   Reboredo-Rodriguez, Patricia
   Mezzetti, Bruno
   Varela-Lopez, Alfonso
   Giampieri, Francesca
   Battino, Maurizio
TI Promising Health Benefits of the Strawberry: A Focus on Clinical Studies
SO JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
LA English
DT Review
DE strawberry; phenolic compounds; anti-inflammation; cardioprotection;
   antimetabolic syndrome; antiobesity; antidiabetes; anticancer;
   neuroprotection
ID FRAGARIA-X-ANANASSA; TOTAL ANTIOXIDANT CAPACITY; C-REACTIVE PROTEIN;
   METABOLIC SYNDROME; PHENOLIC-COMPOUNDS; BIOACTIVE COMPOUNDS; VEGETABLE
   INTAKE; CARDIOVASCULAR-DISEASE; NUTRITIONAL QUALITY; DIETARY PATTERNS
AB The potential health benefits associated with dietary intake of fruits have attracted increasing interest. Among berries, the strawberry is a rich source of several nutritive and non-nutritive bioactive compounds, which are implicated in various health-promoting and disease preventive effects. A plethora of studies have examined the benefits of strawberry consumption, such as prevention of inflammation disorders and oxidative stress; reduction of obesity related disorders and heart disease risk, and protection against various types of cancer. This review provides an overview of their nutritional and non-nutritional bioactive compounds and which factors affect their content in strawberries. In addition, the bioavailability and metabolism of major strawberry phytochemicals as well as their actions in combating many pathologies, including cancer, metabolic syndrome, cardiovascular disease, obesity, diabetes, neurodegeneration, along with microbial pathogenesis have been reviewed, with a particular attention to human studies.
C1 [Afrin, Sadia; Gasparrini, Massimiliano; Forbes-Hernandez, Tamara Y.; Reboredo-Rodriguez, Patricia; Giampieri, Francesca; Battino, Maurizio] Univ Politecn Marche, Fac Med, Dipartimento Sci Clin Specialist & Odontostomatol, Sez Biochim, I-60131 Ancona, Italy.
   [Forbes-Hernandez, Tamara Y.] Univ Int Iberoamer UNINI, Area Nutr & Salud, Campeche 24040, Mexico.
   [Reboredo-Rodriguez, Patricia] Univ Vigo, Fac Food Sci & Technol, Analyt & Food Chem Dept, E-32004 Orense, Spain.
   [Mezzetti, Bruno] Univ Politecn Marche, Dipartirnento Sci Agr Alimentari & Ambientali, Via Ranieri 65, I-60131 Ancona, Italy.
   [Varela-Lopez, Alfonso] Univ Granada, Biomed Res Ctr, Inst Nutr & Food Technol Jose Mataix, Dept Physiol, E-18071 Granada, Spain.
   [Battino, Maurizio] Univ Europea Atlantico UEA, Ctr Nutr & Hlth, Santander 39011, Spain.
C3 Marche Polytechnic University; Universidade de Vigo; Marche Polytechnic
   University; University of Granada
RP Giampieri, F; Battino, M (corresponding author), Univ Politecn Marche, Fac Med, Dipartimento Sci Clin Specialist & Odontostomatol, Sez Biochim, I-60131 Ancona, Italy.; Battino, M (corresponding author), Univ Europea Atlantico UEA, Ctr Nutr & Hlth, Santander 39011, Spain.
EM f.giampieri@univpm.it; m.a.battino@univpm.it
RI Reboredo-Rodríguez, Patricia/AAH-2388-2019; Mezzetti,
   Bruno/AAB-8500-2019; Battino, Maurizio/E-6103-2012; Afrin,
   Sadia/AAQ-5030-2020; Varela-Lopez, Alfonso/F-8055-2016; Giampieri,
   Francesca/I-1911-2015; Forbes Hernandez, Tamara/AAB-1872-2021
OI Afrin, Sadia/0000-0001-5063-9900; Varela-Lopez,
   Alfonso/0000-0002-0504-5086; Mezzetti, Bruno/0000-0001-9307-812X;
   Giampieri, Francesca/0000-0002-8151-9132; Forbes Hernandez,
   Tamara/0000-0001-7021-9276; Reboredo Rodriguez,
   Patricia/0000-0001-8440-6347
FU Fondazione Umberto Veronesi Fellowship
FX Dr. F. Giampieri was supported by a Fondazione Umberto Veronesi
   Fellowship.
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NR 139
TC 211
Z9 230
U1 8
U2 222
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0021-8561
EI 1520-5118
J9 J AGR FOOD CHEM
JI J. Agric. Food Chem.
PD JUN 8
PY 2016
VL 64
IS 22
BP 4435
EP 4449
DI 10.1021/acs.jafc.6b00857
PG 15
WC Agriculture, Multidisciplinary; Chemistry, Applied; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture; Chemistry; Food Science & Technology
GA DO2XB
UT WOS:000377643200001
PM 27172913
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Gupta, V
   Mah, XJ
   Garcia, MC
   Antonypillai, C
   van der Poorten, D
AF Gupta, Vikas
   Mah, Xian-Jun
   Garcia, Maria Carmela
   Antonypillai, Christina
   van der Poorten, David
TI Oily fish, coffee and walnuts: Dietary treatment for nonalcoholic fatty
   liver disease
SO WORLD JOURNAL OF GASTROENTEROLOGY
LA English
DT Review
DE Non-alcoholic fatty liver disease; Non-alcoholic steatohepatitis; Diet;
   Coffee; Tea; Olive oil; Nuts; Walnuts; Fish; Fish oils; Red wine
ID RED WINE POLYPHENOLS; CORONARY-HEART-DISEASE; OLIVE OIL; NUT
   CONSUMPTION; CARDIOVASCULAR-DISEASE; GREEN TEA; INSULIN-RESISTANCE;
   METABOLIC SYNDROME; OXIDATIVE STRESS; RISK-FACTORS
AB Rates of non-alcoholic fatty liver disease (NAFLD) are increasing worldwide in tandem with the metabolic syndrome, with the progressive form of disease, nonalcoholic steatohepatitis (NASH) likely to become the most common cause of end stage liver disease in the not too distant future. Lifestyle modification and weight loss remain the main focus of management in NAFLD and NASH, however, there has been growing interest in the benefit of specific foods and dietary components on disease progression, with some foods showing protective properties. This article provides an overview of the foods that show the most promise and their potential benefits in NAFLD/NASH, specifically; oily fish/fish oil, coffee, nuts, tea, red wine, avocado and olive oil. Furthermore, it summarises results from animal and human trials and highlights potential areas for future research.
C1 [Gupta, Vikas; Mah, Xian-Jun; Garcia, Maria Carmela; Antonypillai, Christina; van der Poorten, David] Univ Sydney, Westmead Hosp, Dept Gastroenterol & Hepatol, Div Med, Westmead, NSW 2145, Australia.
C3 NSW Health; Westmead Hospital; University of Sydney
RP van der Poorten, D (corresponding author), Univ Sydney, Westmead Hosp, Dept Gastroenterol & Hepatol, Div Med, Hawkesbury Rd Westmead, Westmead, NSW 2145, Australia.
EM david.vanderpoorten@sydney.edu.au
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NR 142
TC 33
Z9 36
U1 1
U2 46
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 7041 Koll Center Parkway, Suite 160, PLEASANTON, CA, UNITED STATES
SN 1007-9327
EI 2219-2840
J9 WORLD J GASTROENTERO
JI World J. Gastroenterol.
PD OCT 7
PY 2015
VL 21
IS 37
BP 10621
EP 10635
DI 10.3748/wjg.v21.i37.10621
PG 15
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA CS5LC
UT WOS:000362118500014
PM 26457022
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Muniyappa, R
   Sowers, JR
AF Muniyappa, Ranganath
   Sowers, James R.
TI Role of insulin resistance in endothelial dysfunction
SO REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
LA English
DT Article
DE Nitric oxide; Insulin resistance; Endothelial dysfunction; Metabolic
   syndrome
ID NITRIC-OXIDE SYNTHASE; DEPENDENT DIABETES-MELLITUS;
   POLYCYSTIC-OVARY-SYNDROME; CORONARY-ARTERY-DISEASE; ORAL VITAMIN-C;
   METABOLIC SYNDROME; CARDIOVASCULAR-DISEASE; ESSENTIAL-HYPERTENSION;
   OXIDATIVE STRESS; BLOOD-PRESSURE
AB Insulin resistance is frequently associated with endothelial dysfunction and has been proposed to play a major role in cardiovascular diseases. Insulin exerts pro- and anti-atherogenic actions on the vasculature. The balance between nitric oxide (NO)-dependent vasodilator actions and endothelin-1- dependent vasoconstrictor actions of insulin is regulated by phosphatidylinositol 3-kinase-dependent (PI3K) - and mitogen-activated protein kinase (MAPK)-dependent signaling in vascular endothelium, respectively. During insulin-resistant conditions, pathway-specific impairment in PI3K-dependent signaling may cause imbalance between production of NO and secretion of endothelin-1 and lead to endothelial dysfunction. Insulin sensitizers that target pathway-selective impairment in insulin signaling are known to improve endothelial dysfunction. In this review, we discuss the cellular mechanisms in the endothelium underlying vascular actions of insulin, the role of insulin resistance in mediating endothelial dysfunction, and the effect of insulin sensitizers in restoring the balance in pro- and anti-atherogenic actions of insulin.
C1 [Muniyappa, Ranganath] NIDDK, Clin Endocrine Sect, Diabet Endocrinol & Obes Branch, NIH, Bethesda, MD USA.
   [Sowers, James R.] Univ Missouri, Sch Med, Dept Internal Med, Columbia, MO 65212 USA.
   [Sowers, James R.] Univ Missouri, Sch Med, Dept Med Pharmacol & Physiol, Columbia, MO 65212 USA.
   [Sowers, James R.] Harry S Truman Mem Vet Hosp, Columbia, MO 65201 USA.
C3 National Institutes of Health (NIH) - USA; NIH National Institute of
   Diabetes & Digestive & Kidney Diseases (NIDDK); University of Missouri
   System; University of Missouri Columbia; University of Missouri System;
   University of Missouri Columbia; US Department of Veterans Affairs;
   Veterans Health Administration (VHA); Harry S. Truman Memorial Veterans'
   Hospital
RP Sowers, JR (corresponding author), Univ Missouri, Sch Med, Dept Internal Med, 1 Hosp Dr, Columbia, MO 65212 USA.
EM sowersj@health.missouri.edu
FU Intramural Research Program of National Institute of Diabetes and
   Digestive and Kidney Diseases, National Institutes of Health (NIH); NIH
   [R01 HL73101-08, R01 HL107910-03]; Veterans Affairs Merit System [0018]
FX This work was supported by the Intramural Research Program of National
   Institute of Diabetes and Digestive and Kidney Diseases, National
   Institutes of Health (NIH). The research of J.R.S. is supported by NIH
   (R01 HL73101-08 and R01 HL107910-03) and Veterans Affairs Merit System
   0018.
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NR 78
TC 367
Z9 400
U1 0
U2 62
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1389-9155
J9 REV ENDOCR METAB DIS
JI Rev. Endocr. Metab. Disord.
PD MAR
PY 2013
VL 14
IS 1
BP 5
EP 12
DI 10.1007/s11154-012-9229-1
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 098SC
UT WOS:000315568000002
PM 23306778
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Kino, T
AF Kino, Tomoshige
TI Circadian Rhythms of Glucocorticoid Hormone Actions in Target Tissues:
   Potential Clinical Implications
SO SCIENCE SIGNALING
LA English
DT Article
ID STRESS SYSTEM; CLOCK; RECEPTOR; EXPRESSION; DEPRESSION; DISORDERS;
   MECHANISM; COMPLEX
AB Organisms face unforeseen short- and long-term changes in the environment (stressors). To defend against these changes, organisms have developed a stress system that includes the hypothalamic-pituitary-adrenal (HPA) axis, which employs glucocorticoids and the glucocorticoid receptor (GR) for signal transduction. In addition, organisms live under the strong influence of day-night cycles and, hence, have also developed a highly conserved circadian clock system for adjusting their activities to recurring environmental changes. This regulatory system creates and maintains internal circadian rhythmicity by employing a self-oscillating molecular pacemaker composed of the Clock-Bmal1 heterodimer and other transcription factors. The circadian clock consists of a central master clock in the suprachiasmatic nucleus of the brain hypothalamus and peripheral slave clocks in virtually all organs and tissues. The HPA axis and the circadian clock system communicate with each other at multiple levels. The central clock controls the HPA axis, creating the diurnal oscillation of circulating adrenocorticotropic hormone and cortisol, and the HPA axis adjusts the circadian rhythmicity of the peripheral clocks in response to various stressors through the GR. Further, Clock-Bmal1 regulates the response to glucocorticoids in peripheral tissues through acetylation of the GR, possibly antagonizing the biologic actions of diurnally fluctuating circulating cortisol. Importantly, dysregulation in the clock system and the HPA axis may cause similar pathologic manifestations-including obesity, metabolic syndrome, and cardiovascular disease-by uncoupling circulating cortisol concentrations from tissue sensitivity to glucocorticoids.
C1 Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Program Reprod & Adult Endocrinol, NIH, Bethesda, MD 20892 USA.
C3 National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver
   National Institute of Child Health & Human Development (NICHD)
RP Kino, T (corresponding author), Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Program Reprod & Adult Endocrinol, NIH, Bethesda, MD 20892 USA.
EM kinot@mail.nih.gov
FU Intramural Research Program of NICHD, NIH; Athens University Medical
   School
FX The studies presented were funded by the Intramural Research Program of
   NICHD, NIH, and the Athens University Medical School.
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NR 34
TC 30
Z9 35
U1 0
U2 18
PU AMER ASSOC ADVANCEMENT SCIENCE
PI WASHINGTON
PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA
SN 1945-0877
EI 1937-9145
J9 SCI SIGNAL
JI Sci. Signal.
PD OCT 2
PY 2012
VL 5
IS 244
AR pt4
DI 10.1126/scisignal.2003333
PG 5
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA 022JI
UT WOS:000309954100006
PM 23033538
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Schläfli, P
   Borter, E
   Spielmann, P
   Wenger, RH
AF Schlafli, P.
   Borter, E.
   Spielmann, P.
   Wenger, R. H.
TI The PAS-domain kinase PASKIN: a new sensor in energy homeostasis
SO CELLULAR AND MOLECULAR LIFE SCIENCES
LA English
DT Review
DE Diabetes mellitus; glucose tolerance; glycogen synthesis; insulin;
   metabolic syndrome; nitrogen fixation; protein translation; respiration
ID SERINE/THREONINE KINASE; OXYGEN; EXPRESSION; TRANSCRIPTION; TRANSLATION;
   DEFICIENT; HYPOXIA; CLONING
AB The PAS domain kinase PASKIN, also termed PAS kinase or PASK, is an evolutionarily conserved potential sensor kinase related to the heme-based oxygen sensors of nitrogen-fixing bacteria. In yeast, the two PASKIN homologs link energy flux and protein synthesis following specific stress conditions. In mammals, PASKIN may regulate glycogen synthesis and protein translation. Paskin knock-out mice do not show any phenotype under standard animal husbandry conditions. Interestingly, these mice seem to be protected from the symptoms of the metabolic syndrome when fed a high-fat diet. Energy turnover might be increased in specific PASKIN-deficient cell types under distinct environmental conditions. According to the current model, binding of a putative ligand to the PAS domain disinhibits the kinase domain and activates PASKIN auto- and target phosphorylation. Future research needs to be conducted to elucidate the nature of the putative ligand and the molecular mechanisms of downstream signalling by PASKIN.
C1 [Schlafli, P.; Borter, E.; Spielmann, P.; Wenger, R. H.] Univ Zurich, Inst Physiol & Zurich, Ctr Integrat Human Physiol, Winterthurerstr 190, CH-8057 Zurich, Switzerland.
C3 University of Zurich; Zurich Center Integrative Human Physiology (ZIHP)
RP Wenger, RH (corresponding author), Univ Zurich, Inst Physiol & Zurich, Ctr Integrat Human Physiol, Winterthurerstr 190, CH-8057 Zurich, Switzerland.
EM roland.wenger@access.uzh.ch
RI ; Wenger, Roland H./B-7953-2009
OI Spielmann, Patrick/0000-0001-7056-0351; Wenger, Roland
   H./0000-0001-7592-4839
FU Wolfermann-Nageli-Stiftung; Baugarten Stiftung/Stiftung fur
   Wissenschaftliche Forschung an der Universitat Zurich; Swiss National
   Science Foundation (SNF ) [3100AO-116047/1]
FX Our work is supported by grants obtained from the
   Wolfermann-Nageli-Stiftung, Baugarten Stiftung/Stiftung fur
   Wissenschaftliche Forschung an der Universitat Zurich and the Swiss
   National Science Foundation (SNF 3100AO-116047/1). The authors wish to
   thank C. Aerni, P. Wielinga, B. Alder, C. Loewenstein, T. Lutz, I.
   Tobler, J. Lopez-Barneo, M. Donath, W. Langhans and J. Hillebrand for
   analysis of Paskin knock-out mice and sharing their unpublished data.
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NR 36
TC 25
Z9 31
U1 0
U2 10
PU SPRINGER BASEL AG
PI BASEL
PA PICASSOPLATZ 4, BASEL, 4052, SWITZERLAND
SN 1420-682X
EI 1420-9071
J9 CELL MOL LIFE SCI
JI Cell. Mol. Life Sci.
PD MAR
PY 2009
VL 66
IS 5
BP 876
EP 883
DI 10.1007/s00018-009-8699-0
PG 8
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA 413XP
UT WOS:000263826400010
PM 19189049
OA Green Published
DA 2025-06-11
ER

PT J
AU Saiah, E
AF Saiah, Eddine
TI The role of 11beta-hydroxysteroid dehydrogenase in metabolic disease and
   therapeutic potential of 11beta-HSD1 inhibitors
SO CURRENT MEDICINAL CHEMISTRY
LA English
DT Review
DE 11beta-HSD1; glucocorticoid; metabolic syndrome; diabetes; obesity
ID BETA-KETO SULFONES; SELECTIVE INHIBITORS; 11-BETA-HSD1; DISCOVERY;
   TYPE-1; HYPERGLYCEMIA; RECEPTOR; OBESITY; TARGET
AB Glucocorticoids play an essential role in the regulation of multiple physiological processes, including energy metabolism, maintenance of blood pressure and stress responses, as well as cognitive functions. On a tissue-specific level, glucocorticoid action is controlled by 11beta-hydroxysteroid dehydrogenase enzymes. The type 1 enzyme (11beta-HSD1) is a NADP(H)-dependent bidirectional enzyme in vitro and reduces cortisone to active cortisol in vivo. 11beta-HSD1 is expressed in many tissues including the liver, adipose and skeletal muscles. Chronically elevated local glucocorticoid action as a result of increased 11beta-HSD1 activity has been associated with the metabolic syndrome, which is characterized by obesity, insulin resistance, type 2 diabetes and cardiovascular complications. Recent studies indicate that the inhibition of 11beta-HSD1 mitigates the adverse effects of excessive glucocorticoid levels on metabolic parameters and provides promising opportunities for the development of therapeutic interventions. This review discusses recently disclosed 11beta-HSD1 inhibitors and their potential for the treatment of metabolic disorders.
C1 Wyeth Res, Cambridge, MA 02140 USA.
C3 Pfizer; Wyeth; Pfizer USA
RP Saiah, E (corresponding author), Wyeth Res, 200 Cambridge Pk Dr, Cambridge, MA 02140 USA.
EM esaiah@wyeth.com
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NR 34
TC 40
Z9 50
U1 1
U2 8
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 0929-8673
EI 1875-533X
J9 CURR MED CHEM
JI Curr. Med. Chem.
PD MAR
PY 2008
VL 15
IS 7
BP 642
EP 649
DI 10.2174/092986708783885264
PG 8
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Pharmacology &
   Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
GA 274GU
UT WOS:000253990600002
PM 18336279
DA 2025-06-11
ER

PT J
AU Tóth, ME
   Sárközy, M
   Szucs, G
   Dukay, B
   Hajdu, P
   Zvara, A
   Puskás, LG
   Szebeni, GJ
   Ruppert, Z
   Csonka, C
   Kovács, F
   Kriston, A
   Horváth, P
   Kovári, B
   Cserni, G
   Csont, T
   Sántha, M
AF Toth, Melinda E.
   Sarkozy, Marta
   Szucs, Gergo
   Dukay, Brigitta
   Hajdu, Petra
   Zvara, Agnes
   Puskas, Laszlo G.
   Szebeni, Gabor J.
   Ruppert, Zsofia
   Csonka, Csaba
   Kovacs, Ferenc
   Kriston, Andras
   Horvath, Peter
   Kovari, Bence
   Cserni, Gabor
   Csont, Tamas
   Santha, Miklos
TI Exercise training worsens cardiac performance in males but does not
   change ejection fraction and improves hypertrophy in females in a mouse
   model of metabolic syndrome
SO BIOLOGY OF SEX DIFFERENCES
LA English
DT Article
DE Metabolic syndrome; Hyperlipidemia; Obesity; Endoplasmic reticulum
   stress; Sex-based differences; Endurance training; Cardio-metabolic
   disease; Heart failure; Left ventricular hypertrophy; Diastolic function
ID HUMAN APOLIPOPROTEIN-B; HEAT-SHOCK PROTEINS; SEX-DIFFERENCES; FAILURE;
   LEPTIN; STRESS; GENDER; RAT; NEURODEGENERATION; OVEREXPRESSION
AB Background Metabolic syndrome (MetS) refers to a cluster of co-existing cardio-metabolic risk factors, including visceral obesity, dyslipidemia, hyperglycemia with insulin resistance, and hypertension. As there is a close link between MetS and cardiovascular diseases, we aimed to investigate the sex-based differences in MetS-associated heart failure (HF) and cardiovascular response to regular exercise training (ET). Methods High-fat diet-fed male and female APOB-100 transgenic (HFD/APOB-100, 3 months) mice were used as MetS models, and age- and sex-matched C57BL/6 wild-type mice on standard diet served as healthy controls (SD/WT). Both the SD/WT and HFD/APOB-100 mice were divided into sedentary and ET groups, the latter running on a treadmill (0.9 km/h) for 45 min 5 times per week for 7 months. At month 9, transthoracic echocardiography was performed to monitor cardiac function and morphology. At the termination of the experiment at month 10, blood was collected for serum low-density lipoprotein (LDL)- and high-density lipoprotein (HDL)-cholesterol measurements and homeostatic assessment model for insulin resistance (HOMA-IR) calculation. Cardiomyocyte hypertrophy and fibrosis were assessed by histology. Left ventricular expressions of selected genes associated with metabolism, inflammation, and stress response were investigated by qPCR. Results Both HFD/APOB-100 males and females developed obesity and hypercholesterolemia; however, only males showed insulin resistance. ET did not change these metabolic parameters. HFD/APOB-100 males showed echocardiographic signs of mild HF with dilated ventricles and thinner walls, whereas females presented the beginning of left ventricular hypertrophy. In response to ET, SD/WT males developed increased left ventricular volumes, whereas females responded with physiologic hypertrophy. Exercise-trained HFD/APOB-100 males presented worsening HF with reduced ejection fraction; however, ET did not change the ejection fraction and reversed the echocardiographic signs of left ventricular hypertrophy in HFD/APOB-100 females. The left ventricular expression of the leptin receptor was higher in females than males in the SD/WT groups. Left ventricular expression levels of stress response-related genes were higher in the exercise-trained HFD/APOB-100 males and exercise-trained SD/WT females than exercise-trained SD/WT males. Conclusions HFD/APOB-100 mice showed sex-specific cardiovascular responses to MetS and ET; however, left ventricular gene expressions were similar between the groups except for leptin receptor and several stress response-related genes.
C1 [Toth, Melinda E.; Dukay, Brigitta; Hajdu, Petra; Ruppert, Zsofia; Santha, Miklos] Eotvos Lorand Res Network, Lab Anim Genet & Mol Neurobiol, Biol Res Ctr, Inst Biochem, Temesvari Krt 62, H-6726 Szeged, Hungary.
   [Sarkozy, Marta; Szucs, Gergo; Csonka, Csaba; Csont, Tamas] Univ Szeged, Albert Szent Gyorgyi Med Sch, Dept Biochem, MED Res Grp, Dom Ter 9, H-6720 Szeged, Hungary.
   [Sarkozy, Marta; Szucs, Gergo; Csonka, Csaba; Csont, Tamas] Univ Szeged, Interdisciplinary Ctr Excellence, Dugon Ter 13, H-6720 Szeged, Hungary.
   [Zvara, Agnes; Puskas, Laszlo G.; Szebeni, Gabor J.] Eotvos Lorand Res Network, Biol Res Ctr, Lab Funct Genom, Temesvari Krt 62, H-6726 Szeged, Hungary.
   [Ruppert, Zsofia] Univ Szeged, Doctoral Sch Biol, Szeged, Hungary.
   [Kovacs, Ferenc; Kriston, Andras; Horvath, Peter] Eotvos Lorand Res Network, Inst Biochem, Biol Res Ctr, Synthet & Syst Biol Unit, Temesvari Krt 62, H-6726 Szeged, Hungary.
   [Kovacs, Ferenc; Kriston, Andras; Horvath, Peter] Single Cell Technol Ltd, Temesvari Krt 62, H-6726 Szeged, Hungary.
   [Horvath, Peter] Univ Helsinki, Inst Mol Med Finland FIMM, Helsinki 00014, Finland.
   [Kovari, Bence; Cserni, Gabor] Univ Szeged, Albert Szent Gyorgyi Med Sch, Dept Pathol, Allomas Utca 1, H-6720 Szeged, Hungary.
C3 HUN-REN; HUN-REN Biological Research Center; Institute of Biochemistry -
   HAS; Szeged University; Szeged University; HUN-REN; HUN-REN Biological
   Research Center; Szeged University; HUN-REN; HUN-REN Biological Research
   Center; Institute of Biochemistry - HAS; University of Helsinki; Szeged
   University
RP Tóth, ME (corresponding author), Eotvos Lorand Res Network, Lab Anim Genet & Mol Neurobiol, Biol Res Ctr, Inst Biochem, Temesvari Krt 62, H-6726 Szeged, Hungary.; Sárközy, M (corresponding author), Univ Szeged, Albert Szent Gyorgyi Med Sch, Dept Biochem, MED Res Grp, Dom Ter 9, H-6720 Szeged, Hungary.; Sárközy, M (corresponding author), Univ Szeged, Interdisciplinary Ctr Excellence, Dugon Ter 13, H-6720 Szeged, Hungary.
EM toth.erzsebetmelinda@brc.hu; sarkozy.marta@med.u-szeged.hu
RI Kovari, Bence/AAA-3346-2021; Szűcs, Gergő/O-8732-2019; Kovács,
   Ferenc/ABB-1658-2021; Cserni, Gabor/JCN-6784-2023; Sarkozy,
   Marta/G-1657-2016
OI Toth, Melinda/0000-0002-5529-6967; Szebeni, Gabor
   J./0000-0002-6998-5632; Szucs, Gergo/0000-0003-1874-2718; Sarkozy,
   Marta/0000-0002-5929-2146
FU New National Excellence Program of the Ministry of Human Capacities
   [UNKP-20-5-SZTE-166, UNKP-19-4-SZTE-89]; Janos Bolyai Research
   Fellowship of the Hungarian Academy of Sciences; Ministry for Innovation
   and Technology [UNKP-21-4-SZTE-483];  [GINOP-2.3.2-152016-00040]; 
   [GINOP-2.3.2-15-2016-00060];  [NKFIH K115990];  [NKFIH FK129094]; 
   [NKFIH FK138390];  [TKP2021-EGA-32];  [20391-3/2018/FEKUSTRAT]
FX This research and publication were funded by the projects
   GINOP-2.3.2-152016-00040, GINOP-2.3.2-15-2016-00060, NKFIH K115990,
   NKFIH FK129094, NKFIH FK138390, TKP2021-EGA-32 and
   20391-3/2018/FEKUSTRAT. MS (Marta Sarkozy) is supported by the New
   National Excellence Program of the Ministry of Human Capacities
   (UNKP-20-5-SZTE-166, UNKP-19-4-SZTE-89) and the Janos Bolyai Research
   Fellowship of the Hungarian Academy of Sciences. BD is supported by the
   UNKP-21-4-SZTE-483 New National Excellence Program of the Ministry for
   Innovation and Technology.
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NR 58
TC 10
Z9 10
U1 1
U2 9
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 2042-6410
J9 BIOL SEX DIFFER
JI Biol. Sex Differ.
PD JAN 31
PY 2022
VL 13
IS 1
AR 5
DI 10.1186/s13293-022-00414-6
PG 19
WC Endocrinology & Metabolism; Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Genetics & Heredity
GA YS2KU
UT WOS:000750512300001
PM 35101146
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Lundström, S
   Jormfeldt, H
   Ahlström, BH
   Skärsäter, I
AF Lundstrom, Sofie
   Jormfeldt, Henrika
   Ahlstrom, Britt Hedman
   Skarsater, Ingela
TI Health-related lifestyle and perceived health among people with severe
   mental illness: Gender differences and degree of sense of coherence
SO ARCHIVES OF PSYCHIATRIC NURSING
LA English
DT Article
DE Health; Lifestyle; Sense of Coherence; Severe mental illness; Quality of
   Life
ID QUALITY-OF-LIFE; ANTONOVSKYS SENSE; SEDENTARY BEHAVIOR; METABOLIC
   SYNDROME; PHYSICAL-ACTIVITY; BIPOLAR DISORDER; OBESE ADULTS;
   SCHIZOPHRENIA; MORTALITY; SYMPTOMS
AB People with severe mental illness (SMI) experience an increased risk of physical ill health and premature death, which appears to be partly related to unhealthy lifestyle habits. The aim of this study was to describe the distribution of health-related lifestyle habits and perceived health among people with severe mental illness. A further aim was to explore if there were any gender differences or differences based on degree of sense of coherence. The study adopted a cross-sectional design based on data from 65 people with SMI. The results show that degree of Sense of Coherence (SOC) does have relevance for perceived health and for dimensions of Quality of Life (QOL). Furthermore, among the participants with strong SOC, there were less daily smokers and they seemed to have less sedentary leisure time than those with low SOC. Men reported more anxiety/depression than women and women ate fruit more often than men, otherwise there were no gender differences. In comparison with the general population, people with SMI show a higher Body Mass Index are more sedentary, more often daily smokers, have lower SOC and perceive a lower QOL. This emphasizes the importance of health-promotion support that focuses on lifestyle changes, and support for strengthening SOC and QOL for people with SMI.
C1 [Lundstrom, Sofie; Jormfeldt, Henrika; Skarsater, Ingela] Halmstad Univ, Sch Hlth & Welf, Kristians IV S Vag 3, S-30118 Halmstad, Sweden.
   [Ahlstrom, Britt Hedman] Univ West, Dept Hlth Sci, Trollhattan, Sweden.
C3 Halmstad University; University West - Sweden
RP Lundström, S (corresponding author), Halmstad Univ, Sch Hlth & Welf, Kristians IV S Vag 3, S-30118 Halmstad, Sweden.
EM sofie.lundstrom@hh.se
RI Ahlström, Britt/Y-8217-2019
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NR 66
TC 10
Z9 10
U1 2
U2 14
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0883-9417
EI 1532-8228
J9 ARCH PSYCHIAT NURS
JI Arch. Psychiatr. Nurs.
PD APR
PY 2019
VL 33
IS 2
BP 182
EP 188
DI 10.1016/j.apnu.2018.12.002
PG 7
WC Nursing; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Psychiatry
GA HW6XH
UT WOS:000466833600008
PM 30927988
DA 2025-06-11
ER

PT J
AU Misiak, B
   Kiejna, A
   Frydecka, D
AF Misiak, Blazej
   Kiejna, Andrzej
   Frydecka, Dorota
TI The history of childhood trauma is associated with lipid disturbances
   and blood pressure in adult first-episode schizophrenia patients
SO GENERAL HOSPITAL PSYCHIATRY
LA English
DT Article
DE First-episode schizophrenia; Blood pressure; Lipids; Childhood trauma;
   Early life stress
ID POSTTRAUMATIC-STRESS-DISORDER; ONE-CARBON METABOLISM; CYTOKINE
   ALTERATIONS; METAANALYSIS; PSYCHOSIS; VETERANS; DEPRESSION; EXERCISE;
   ABUSE
AB Objective: It has repeatedly been found that early-life traumatic events may contribute to metabolic dysregulation. Therefore, the aim of this study was to investigate the association between the history of childhood trauma and cardiovascular risk factors in first-episode schizophrenia (FES) patients.
   Method: The history of childhood traumawas assessed using the Early Trauma Inventory Self Report-Short Form (ETISR-SF) in 83 FES patients. Based on the ETISR-SF, patients were divided into those with positive and negative history of childhood trauma: FES(+) and FES(-) patients. Serum levels of fasting glucose lipids, homocysteine, vitamin B12 and folate, as well as anthropometric parameters and resting systolic and diastolic blood pressure (SBP and DBP) were measured.
   Results: The history of childhood trauma was associated with higher low-density lipoprotein (LDL) levels, SBP and DBP after covarying for age, gender, body mass index, education and chlorpromazine equivalent. There were significant correlations between scores of distinct ETISR-SF subscales and LDL, high-density lipoprotein, SBP, DBP and the number of metabolic syndrome criteria.
   Conclusions: Results of this study indicate that traumatic events during childhood might be related to higher resting blood pressure and higher LDL levels in adult FES patients. (C) 2015 Elsevier Inc. All rights reserved.
C1 [Misiak, Blazej; Kiejna, Andrzej; Frydecka, Dorota] Wroclaw Med Univ, Dept Psychiat, PL-50367 Wroclaw, Poland.
   [Misiak, Blazej] Wroclaw Med Univ, Dept Genet, PL-50368 Wroclaw, Poland.
C3 Wroclaw Medical University; Wroclaw Medical University
RP Misiak, B (corresponding author), Wroclaw Med Univ, Dept Psychiat, 10 Pasteur St, PL-50367 Wroclaw, Poland.
EM mblazej@interia.eu
RI Frydecka, Dorota/ABD-8176-2021; Misiak, Błażej/ABA-2657-2021
OI Misiak, Blazej/0000-0002-5392-6398; Frydecka, Dorota/0000-0001-8582-9958
FU National Science Center [DEC-2011/03/N/NZ5/00248]; START scholarship by
   Foundation for Polish Science
FX We are deeply grateful to all patients participating in this study. This
   work was supported by the research grant awarded by National Science
   Center (decision number: DEC-2011/03/N/NZ5/00248). Blazej Misiak is
   supported by the START scholarship provided by the Foundation for Polish
   Science.
CR [Anonymous], NEUROSCI BIOBEHAV RE
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NR 34
TC 24
Z9 28
U1 1
U2 14
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0163-8343
EI 1873-7714
J9 GEN HOSP PSYCHIAT
JI Gen. Hosp. Psych.
PD JUL-AUG
PY 2015
VL 37
IS 4
BP 365
EP 367
DI 10.1016/j.genhosppsych.2015.03.017
PG 3
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA CJ5UG
UT WOS:000355555800017
PM 25881769
DA 2025-06-11
ER

PT J
AU Fan, WX
   Huang, YL
   Zheng, H
   Li, SQ
   Li, ZH
   Yuan, L
   Cheng, X
   He, CS
   Sun, JF
AF Fan, Wenxiang
   Huang, Yongliang
   Zheng, Hui
   Li, Shuiqin
   Li, Zhuohong
   Yuan, Li
   Cheng, Xi
   He, Chengshi
   Sun, Jianfeng
TI Ginsenosides for the treatment of metabolic syndrome and cardiovascular
   diseases: Pharmacology and mechanisms
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Review
DE Metabolic syndrome; Cardiovascular diseases; Ginsenosides; Signaling
   pathways; Mechanism
ID ACTIVATED PROTEIN-KINASE; NF-KAPPA-B; PANAX-NOTOGINSENG SAPONINS; ACUTE
   ISCHEMIC-STROKE; INSULIN-RESISTANCE; COMPOUND K; HYPOXIA/REOXYGENATION
   INJURY; GLUCOCORTICOID-RECEPTOR; OXIDATIVE STRESS; ADIPOSE-TISSUE
AB Epidemiological studies showed that the metabolic syndromes (MetS) and cardiovascular diseases (CVDs) are responsible for a serious threat to human health worldwide. MetS is a syndromes characterized by fat metabolism disorder, obesity, diabetes, insulin resistance and other risk factors, which increases the risk of CVDs initiation and development. Although certain drugs play a role in lowering blood sugar and lipid, some side effects also occur. Considering the multiple pathogenesis, a great deal of natural products have been attempted to treat metabolic syndromes. Ginsenosides, as the active components isolated from Panax ginseng C.A.Mey, have been reported to have therapeutic effects on MetS and CVDs, of which pharmacological mechanisms were further studied as well. This review aims to systematically summarize current pharmacological effects of ginsenosides on MetS and CVDs, potential mechanisms and clinic trials, which will greatly contribute to the development of potential agents for related disease treatment.
C1 [Fan, Wenxiang] Shanghai Univ Tradit Chinese Med, Inst Chinese Mat Med, Shanghai 201203, Peoples R China.
   [Huang, Yongliang; Zheng, Hui; Li, Shuiqin; Li, Zhuohong; Yuan, Li; Cheng, Xi; He, Chengshi; Sun, Jianfeng] Hosp Chengdu Univ Tradit Chinese Med, 39 Shierqiao Rd, Chengdu 610072, Peoples R China.
C3 Shanghai University of Traditional Chinese Medicine; Chengdu University
   of Traditional Chinese Medicine
RP He, CS; Sun, JF (corresponding author), Hosp Chengdu Univ Tradit Chinese Med, 39 Shierqiao Rd, Chengdu 610072, Peoples R China.
EM hechengshicdutcm@163.com; sunjianfeng731@163.com
FU National Natural Science Foundation of China [81503254]; Research
   Promotion Plan for Xinglin Scholars in Chengdu University of Traditional
   Chinese Medicine [QNXZ2019018]; Science and technology development fund
   project of Hospital of Chengdu University of traditional Chinese
   Medicine [Y2019128, Y2018006, Y2019114]
FX This research was funded by National Natural Science Foundation of China
   (no.81503254); Research Promotion Plan for Xinglin Scholars in Chengdu
   University of Traditional Chinese Medicine (no. QNXZ2019018); Science
   and technology development fund project of Hospital of Chengdu
   University of traditional Chinese Medicine (no. Y2019128); Science and
   technology development fund project of Hospital of Chengdu University of
   traditional Chinese Medicine (no. Y2018006); Science and technology
   development fund project of Hospital of Chengdu University of
   traditional Chinese Medicine (no. Y2019114).
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NR 202
TC 132
Z9 143
U1 10
U2 99
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD DEC
PY 2020
VL 132
AR 110915
DI 10.1016/j.biopha.2020.110915
PG 19
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA OX6WU
UT WOS:000593703200006
PM 33254433
OA gold
DA 2025-06-11
ER

PT J
AU Kachur, S
   Morera, R
   De Schutter, A
   Lavie, CJ
AF Kachur, Sergey
   Morera, Rebecca
   De Schutter, Alban
   Lavie, Carl J.
TI Cardiovascular Risk in Patients with Prehypertension and the Metabolic
   Syndrome
SO CURRENT HYPERTENSION REPORTS
LA English
DT Review
DE Metabolic syndrome; Obesity; Prehypertension; Heart failure; Insulin
   resistance
ID CIRCULATING OXIDIZED LDL; BODY-MASS INDEX; ENDOTHELIAL DYSFUNCTION;
   INSULIN-RESISTANCE; LONG-TERM; DIABETES-MELLITUS; OXIDATIVE STRESS;
   BLOOD-PRESSURE; HEART-FAILURE; WEIGHT-LOSS
AB Prehypertension (pHTN) andmetabolic syndrome (MetS) are both lifestyle diseases that are potentiated by increased adiposity, as both disease processes are closely related to weight. In the case of pHTN, increased adiposity causes dysregulation of the renin-angiotensin-aldosterone-system (RAAS) as well as adipokine-and leptin-associated increases in adrenergic tone. In MetS, excess weight potentiates hyperglycemia and insulin resistance which causes positive feedback into the RAAS system, activates an inflammatory cascade that potentiates atherosclerosis, and causes lipid dysregulation which together contribute to cardiovascular disease, especially coronary heart disease (CHD) and heart failure (HF). The relationship with all-cause mortality is not as clear-cut in part because of some protective effects associated with the obesity paradox in chronic diseases such as CHD and HF. However, in healthy populations, the absence of excess weight and its associated effects on prehypertension and MetS are associated with a longer absolute and disease-free lifespan.
C1 [Kachur, Sergey; Morera, Rebecca] Ocala Reg Med Ctr, Dept Grad Med Educ, 1431 SW 1st Ave, Ocala, FL 34471 USA.
   [De Schutter, Alban] NYU, Sch Med, New York, NY USA.
   [Lavie, Carl J.] Univ Queensland, Sch Med, Dept Cardiovasc Dis, Ochsner Clin Sch,John Ochsner Heart & Vasc Inst, New Orleans, LA USA.
C3 New York University; University of Queensland; Ochsner Health System
RP Kachur, S (corresponding author), Ocala Reg Med Ctr, Dept Grad Med Educ, 1431 SW 1st Ave, Ocala, FL 34471 USA.
EM Sergey.kachur@gmail.com
RI Lavie, Carl/A-6014-2011
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NR 79
TC 30
Z9 38
U1 0
U2 13
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1522-6417
EI 1534-3111
J9 CURR HYPERTENS REP
JI Curr. Hypertens. Rep.
PD FEB
PY 2018
VL 20
IS 2
AR 15
DI 10.1007/s11906-018-0801-2
PG 9
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA GA5SC
UT WOS:000428392900007
PM 29511907
DA 2025-06-11
ER

PT J
AU Tessari, P
   Coracina, A
   Cosma, A
   Tiengo, A
AF Tessari, P.
   Coracina, A.
   Cosma, A.
   Tiengo, A.
TI Hepatic lipid metabolism and non-alcoholic fatty liver disease
SO NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
LA English
DT Review
DE Fatty liver; Insulin; Metabolic syndrome; Hepatic lipid; metabolism;
   Microsome; Peroxidation; Gene expression; Lipoprotein export; Metformin;
   Apoptosis
ID ACTIVATED PROTEIN-KINASE; LOW-DENSITY LIPOPROTEIN; ACETYL-COA
   CARBOXYLASE; DE-NOVO LIPOGENESIS; INSULIN-RESISTANCE; SKELETAL-MUSCLE;
   IN-VIVO; ACID OXIDATION; TRANSCRIPTION FACTOR; GENE-EXPRESSION
AB Non-alcoholic fatty liver disease (NAFLD) is an increasingly recognized pathology with a high prevalence and a possible evolution to its inflammatory counterpart (non-alcoholic steatohepatitis, or NASH). The pathophysiology of NAFLD and NASH has many links with the metabolic syndrome, sharing a causative factor in insulin resistance. According to a two-hit hypothesis, increased intrahepatic triglyceride accumulation (due to increased synthesis, decreased export, or both) is followed by a second step (or "hit"), which may lead to NASH. The tatter likely involves oxidative stress, cytochrome P450 activation, lipid peroxidation, increased inflammatory cytokine production, activation of hepatic stellate cells and apoptosis. However, both "hits" may be caused by the same factors. The aim of this article is to overview the biochemical steps of fat regulation in the liver and the alterations occurring in the pathogenesis of NAFLD and NASH. (c) 2009 Elsevier B.V. All rights reserved.
C1 [Tessari, P.; Coracina, A.; Cosma, A.; Tiengo, A.] Univ Padua, Chair Metab, Dept Clin & Expt Med, I-35100 Padua, Italy.
C3 University of Padua
RP Tessari, P (corresponding author), Univ Padua Polyclin, Chair Metab, Dept Clin & Expt Med, Via Giustiniani 2, I-35128 Padua, Italy.
EM paolo.tessari@unipd.it
OI Tessari, Paolo/0000-0002-4570-9238
FU University of Padova; PhD program of "Fondazione Cassa di Risparmio di
   Padova e Rovigo", Italy
FX Grants: This study was supported by Research Grants of the University of
   Padova (years 2006-2007) and from a PhD program of "Fondazione Cassa di
   Risparmio di Padova e Rovigo", Italy.
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NR 127
TC 255
Z9 299
U1 3
U2 55
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0939-4753
EI 1590-3729
J9 NUTR METAB CARDIOVAS
JI Nutr. Metab. Carbiovasc. Dis.
PD MAY
PY 2009
VL 19
IS 4
BP 291
EP 302
DI 10.1016/j.numecd.2008.12.015
PG 12
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism; Nutrition
   & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism;
   Nutrition & Dietetics
GA 459WA
UT WOS:000267141800010
PM 19359149
DA 2025-06-11
ER

PT J
AU Fava, A
   Plastino, M
   Cristiano, D
   Spanò, A
   Cristofaro, S
   Opipari, C
   Chillà, A
   Casalinuovo, F
   Colica, C
   De Bartolo, M
   Pirritano, D
   Bosco, D
AF Fava, Antonietta
   Plastino, Massimiliano
   Cristiano, Dario
   Spano, Antonio
   Cristofaro, Stefano
   Opipari, Carlo
   Chilla, Antonio
   Casalinuovo, Fatima
   Colica, Carmen
   De Bartolo, Matteo
   Pirritano, Domenico
   Bosco, Domenico
TI Insulin resistance possible risk factor for cognitive impairment in
   fibromialgic patients
SO METABOLIC BRAIN DISEASE
LA English
DT Article
DE Cognitive deficits; Dementia; Diabetes mellitus; Pain syndrome; Insulin
   resistance
ID METABOLIC SYNDROME; PRIMARY FIBROMYALGIA; GLUCOSE-METABOLISM;
   DIABETES-MELLITUS; MEMORY; DEPRESSION; CRITERIA; NOREPINEPHRINE;
   DEMENTIA; OBESITY
AB To evaluate glucose metabolism and/or insulin resistance (IR) in 96 patients with Fibromyalgia (FM), associated or not to cognitive impairment. We investigated glucose metabolism in 96 FM patients. Enrolled patients were divided into two groups: 48 patients with memory deficit (group A) and 48 without memory deficit (control group). We evaluated glucose and insulin levels after a 2 h-Oral-Glucose-Tolerance-Test (2 h-OGTT) and insulin resistance (IR) by the homeostasis model assessment formula (HOMA). Body Mass Index (BMI), waist-to-hip-ratio (WHR), anxiety level, fasting plasma insulin and Non-Steroidal Anti-Inflammatory agents use were higher in patients with FM with memory impairment; while age, sex, waist circumference, education level, fasting plasma glucose, glycate hemoglobin, triglycerides, blood lipid profile, C- Reactivity-Protein (CRP), blood pressure and smoking habits were similar in both groups. Following OGTT the prevalence of glucose metabolism abnormalities was significantly higher in group A. IR was present in 79 % patients, of whom 23 % had also impaired glucose tolerance, 4 % newly diagnosed diabetes mellitus and 52 % IR only. Obesity and overweight prevailed in group A. IR, but not BMI or WHR was associated to an increased risk of memory impairment (OR = 2,6; 95 % CI: 1,22-3,7). The results of this study suggest that IR may represent a risk factor for memory impairment in fibromialgic patients.
C1 [Fava, Antonietta] Fdn UALSI, I-88100 Catanzaro, Italy.
   [Plastino, Massimiliano; Cristiano, Dario; Spano, Antonio; Cristofaro, Stefano; Opipari, Carlo; Casalinuovo, Fatima; Pirritano, Domenico; Bosco, Domenico] S Giovanni di Dio Hosp, Dept Neurosci, I-88900 Largo Bologna, Crotone, Italy.
   [Chilla, Antonio] S Giovanni di Dio Hosp, Dept Psychiat, I-88900 Crotone, Italy.
   [Colica, Carmen] CNR, I-88100 Catanzaro, Italy.
   [De Bartolo, Matteo] Hosp Rossano, Neurophysiol Unit, I-80068 Rossano, Italy.
C3 Consiglio Nazionale delle Ricerche (CNR)
RP Bosco, D (corresponding author), S Giovanni di Dio Hosp, Dept Neurosci, I-88900 Largo Bologna, Crotone, Italy.
EM nico_bosco@libero.it
RI Bosco, Domenico/K-6806-2016; Colica, Carmela/AAY-4131-2020; pirritano,
   domenico/AAD-1971-2022
OI Bosco, Domenico/0000-0003-3453-9613
CR [Anonymous], DIABETES CARE S1
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NR 51
TC 26
Z9 27
U1 0
U2 9
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0885-7490
EI 1573-7365
J9 METAB BRAIN DIS
JI Metab. Brain Dis.
PD DEC
PY 2013
VL 28
IS 4
BP 619
EP 627
DI 10.1007/s11011-013-9421-3
PG 9
WC Endocrinology & Metabolism; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology
GA 240OJ
UT WOS:000326106200010
PM 23892884
DA 2025-06-11
ER

PT J
AU Ertelt, A
   Barton, AK
   Schmitz, RR
   Gehlen, H
AF Ertelt, Antonia
   Barton, Ann-Kristin
   Schmitz, Robert R.
   Gehlen, Heidrun
TI Metabolic syndrome: is equine disease comparable to what we know in
   humans?
SO ENDOCRINE CONNECTIONS
LA English
DT Review
DE metabolism; obesity; diabetes; cardiovascular; inflammation
ID VISCERAL ADIPOSE-TISSUE; NECROSIS-FACTOR-ALPHA; INSULIN-RESISTANCE;
   ENDOTHELIAL DYSFUNCTION; DENSITY-LIPOPROTEIN; OXIDATIVE STRESS; BODY
   CONDITION; RISK-FACTORS; RECEPTOR; FAT
AB This review summarizes similarities and differences between the metabolic syndromes in humans and equines, concerning the anatomy, symptoms, and pathophysiological mechanisms. In particular, it discusses the structure and distribution of adipose tissue and its specific metabolic pathways. Furthermore, this article provides insights and focuses on issues concerning laminitis in horses and cardiovascular diseases in humans, as well as their overlap.
C1 [Ertelt, Antonia; Barton, Ann-Kristin; Schmitz, Robert R.; Gehlen, Heidrun] Free Univ Berlin, Equine Clin, Berlin, Germany.
C3 Free University of Berlin
RP Ertelt, A (corresponding author), Free Univ Berlin, Equine Clin, Berlin, Germany.
EM antonia.ertelt@fu-berlin.de
RI Barton, Ann Kristin/LPP-4522-2024
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NR 128
TC 27
Z9 32
U1 0
U2 19
PU BIOSCIENTIFICA LTD
PI BRISTOL
PA EURO HOUSE, 22 APEX COURT WOODLANDS, BRADLEY STOKE, BRISTOL BS32 4JT,
   ENGLAND
SN 2049-3614
J9 ENDOCR CONNECT
JI Endocr. Connect.
PD SEP 1
PY 2014
VL 3
IS 3
BP R81
EP R93
DI 10.1530/EC-14-0038
PG 13
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA V44UN
UT WOS:000209774000001
PM 24894908
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Syk, M
   Isaksson, J
   Rasmusson, AJ
   Ekselius, L
   Cunningham, JL
AF Syk, Mikaela
   Isaksson, Johan
   Rasmusson, Annica J.
   Ekselius, Lisa
   Cunningham, Janet L.
TI Neuroticism is positively associated with leptin/adiponectin ratio,
   leptin and IL-6 in young adults
SO SCIENTIFIC REPORTS
LA English
DT Article
ID SWEDISH UNIVERSITIES SCALES; PERSONALITY-TRAITS; CARDIOVASCULAR-DISEASE;
   INFLAMMATORY BIOMARKERS; METABOLIC SYNDROME; LIFE-STYLE; 5-FACTOR MODEL;
   UK HEALTH; RISK; DEPRESSION
AB High neuroticism is related to cardiovascular morbidity. Early detection of metabolic and cardiovascular risk is important in high-risk groups to enable preventive measures. The aim of this study was therefore to explore if neuroticism is associated with early biomarkers for cardiovascular and metabolic disease in young adults from a psychiatry cohort. Blood samples and self-ratings on neuroticism with the Swedish universities Scales of Personality (SSP) questionnaire were collected from 172 psychiatric outpatients and 46 healthy controls. The blood samples were analysed for plasma leptin, adiponectin, CRP, IL-6 and TNF-alpha. Associations between neuroticism and biomarkers were assessed using Spearman's correlation coefficients and generalized linear models adjusting for confounders. In the adjusted generalized linear models, neuroticism predicted the leptin/adiponectin ratio (p = 0.003), leptin (p = 0.004) and IL-6 (p = 0.001). These associations were not better explained by current major depressive disorder and/or anxiety disorder. Adiponectin, CRP and TNF-alpha were not associated with neuroticism. In conclusion, the findings suggest that high neuroticism is related to elevated levels of plasma leptin/adiponectin ratio, leptin and IL-6 in young adults. Young adults with high neuroticism may therefore benefit from preventive interventions to decrease the risk for future metabolic and cardiovascular morbidity, but more research is required to test this hypothesis.
C1 [Syk, Mikaela; Rasmusson, Annica J.; Ekselius, Lisa; Cunningham, Janet L.] Uppsala Univ, Akad Sjukhuset, Dept Neurosci, Psychiat, S-75185 Uppsala, Sweden.
   [Isaksson, Johan] Uppsala Univ, Dept Neurosci Child & Adolescent Psychiat, Uppsala, Sweden.
C3 Uppsala University; Uppsala University Hospital; Uppsala University
RP Syk, M (corresponding author), Uppsala Univ, Akad Sjukhuset, Dept Neurosci, Psychiat, S-75185 Uppsala, Sweden.
EM Mikaela.syk@neuro.uu.se
RI Cunningham, Janet/C-4719-2013
OI Isaksson, Johan/0000-0003-1033-2618; Cunningham,
   Janet/0000-0001-7876-7779
FU Marta och Nicke Nasvells stiftelse; Ekhaga foundation; Fredrik och
   Ingrid Thurings stiftelse; Stiftelsen Soderstrom-Konigska sjukhemmet;
   Uppsala University Hospital Research Fund (ALF); Bissen Brainwalk
FX This research was funded by grants from Marta och Nicke Nasvells
   stiftelse; Bissen Brainwalk; Ekhaga foundation, Fredrik och Ingrid
   Thurings stiftelse; Stiftelsen Soderstrom-Konigska sjukhemmet; Uppsala
   University Hospital Research Fund (ALF).
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NR 74
TC 11
Z9 12
U1 0
U2 7
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD MAY 7
PY 2021
VL 11
IS 1
AR 9690
DI 10.1038/s41598-021-89251-y
PG 10
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Science & Technology - Other Topics
GA SK8JJ
UT WOS:000656462600001
PM 33963214
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Warreman, EB
   Nooteboom, LA
   Leenen, PJM
   Geurts, HM
   Terry, MB
   Bos, JHJ
   Hak, E
   Hoek, HW
   van Rossum, EFC
   Vermeiren, RRJM
   Ester, WA
AF Warreman, E. B.
   Nooteboom, L. A.
   Leenen, P. J. M.
   Geurts, H. M.
   Terry, M. B.
   Bos, J. H. J.
   Hak, E.
   Hoek, H. W.
   van Rossum, E. F. C.
   Vermeiren, R. R. J. M.
   Ester, W. A.
TI Metabolic syndrome in adults with autistic traits: associated
   psychological, behavioral, and biological factors in females and males -
   a PharmLines initiative
SO FRONTIERS IN PSYCHIATRY
LA English
DT Article
DE autism; autistic traits; cardiovascular risk; metabolic syndrome; adults
ID MYOCARDIAL-INFARCTION; SPECTRUM QUOTIENT; DATABASE IADB.NL;
   RISK-FACTORS; 52 COUNTRIES; HEALTH; STRESS; ADOLESCENTS; COMORBIDITY;
   INTERHEART
AB Background : While cardiovascular diseases is highly prevalent and an important cause of mortality in autistic adults, knowledge on their increased cardiovascular risk is limited. Hence, this study aimed to investigate psychological, behavioral, and physical factors associated with metabolic syndrome (MetS) in adults with autistic traits.Methods : In total, 17,705 adults from the Lifelines Cohort were included and categorized using Autism Spectrum Quotient-10 sum-scores. The quartiles with highest (HQ-traits-group females: n = 2,635; males: n = 1803) and lowest levels of autistic traits (LQ-traits-group, n = idem) were analyzed. Using multivariable logistic regression, the associations between MetS and (self-reported and interviewed) psychological, behavioral, and physically measured factors in these stratified groups were investigated.Results : Among females, MetS was more common in the HQ-traits-group than in the LQ-traits-group (10.0% versus 7.5%, p < 0.01), while this was not the case among males (HQ-traits-group 13.8% versus LQ-traits-group 13.1%, p = 0.52). In both the female and male HQ-traits-group, the presence of MetS was associated with poorer self-reported health, less daily physical activity, and altered leukocyte counts.Conclusion These findings underline the relevance of adequate cardiovascular prevention in adults with higher levels of autistic traits. Future research could gain more insight into the relationship between cardiovascular risk and autistic traits in females, and into tailored cardiovascular prevention.
C1 [Warreman, E. B.; Nooteboom, L. A.; Vermeiren, R. R. J. M.; Ester, W. A.] Leiden Univ, Med Ctr, LUMC Curium, Dept Child & Adolescent Psychiat, Oegstgeest, Netherlands.
   [Leenen, P. J. M.] Univ Med Ctr Rotterdam, Dept Immunol, Erasmus MC, Rotterdam, Netherlands.
   [Geurts, H. M.] Univ Amsterdam, Dutch Autism & ADHD Res Ctr, Dept Psychol, Amsterdam, Netherlands.
   [Geurts, H. M.] Dr Leo Kannerhuis Youz Parnassia Grp, Amsterdam, Netherlands.
   [Terry, M. B.; Hoek, H. W.] Columbia Univ, Mailman Sch Publ Hlth, Dept Epidemiol, New York, NY USA.
   [Bos, J. H. J.; Hak, E.] Univ Groningen, Groningen Res Inst Pharm Pharmacotherapy Epidemiol, Groningen, Netherlands.
   [Hoek, H. W.] Univ Med Ctr Groningen, Dept Psychiat, Groningen, Netherlands.
   [Hoek, H. W.; Vermeiren, R. R. J. M.; Ester, W. A.] Parnassia Grp, The Hague, Netherlands.
   [van Rossum, E. F. C.] Univ Med Ctr Rotterdam, Dept Internal Med, Div Endocrinol, Erasmus MC, Rotterdam, Netherlands.
   [van Rossum, E. F. C.] Univ Med Ctr Rotterdam, Obes Ctr CGG, Erasmus MC, Rotterdam, Netherlands.
   [Ester, W. A.] Parnassia Grp, Sarr Autism Rotterdam Youz, Rotterdam, Netherlands.
C3 Leiden University; Leiden University Medical Center (LUMC); Leiden
   University - Excl LUMC; Erasmus University Rotterdam; Erasmus MC;
   University of Amsterdam; Columbia University; University of Groningen;
   University of Groningen; Parnassia Psychiatric Institute; Erasmus
   University Rotterdam; Erasmus MC; Erasmus University Rotterdam; Erasmus
   MC; Parnassia Psychiatric Institute
RP Warreman, EB (corresponding author), Leiden Univ, Med Ctr, LUMC Curium, Dept Child & Adolescent Psychiat, Oegstgeest, Netherlands.
EM E.B.Warreman@lumc.nl
RI Leenen, Pieter/I-5839-2013; Mohamadi, Efat/ABD-8458-2020; Ester,
   Wietske/JZE-1102-2024; van Rossum, Elisabeth/AAP-9388-2020
OI Vermeiren, Robert/0000-0002-8673-2207; van Rossum,
   Elisabeth/0000-0003-0120-4913
FU Ministry of Health10.13039/501100004726
FX We wish to acknowledge the services of the Lifelines Cohort Study, all
   study participants, the contributing research centres delivering data to
   Lifelines, and the participating IADB.nl pharmacies for providing their
   data for research. We also thank the members of Dutch 'Academic
   Workplace for Autism' for contributing to this study by sharing useful
   insights regarding the importance of selected study outcomes for the
   autistic population.
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NR 40
TC 0
Z9 0
U1 1
U2 6
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-0640
J9 FRONT PSYCHIATRY
JI Front. Psychiatry
PD DEC 18
PY 2023
VL 14
AR 1303840
DI 10.3389/fpsyt.2023.1303840
PG 10
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA DT0U4
UT WOS:001134214800001
PM 38193131
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Yang, ZY
   Fang, WH
   Kao, CC
   Chen, WL
AF Yang, Zhe-Yu
   Fang, Wen-Hui
   Kao, Chia-Chun
   Chen, Wei-Liang
TI Examining the association between serum IgG of oral bacteria and
   metabolic syndrome
SO FRONTIERS IN MEDICINE
LA English
DT Article
DE periodontitis; periodontal bacteria; metabolic syndrome;
   EPI-epidemiology; multivariate analysis
ID NECROSIS-FACTOR-ALPHA; PERIODONTAL BACTERIA; OXIDATIVE STRESS; SYSTEMIC
   INFLAMMATION; CYTOKINE PRODUCTION; INSULIN-RESISTANCE; ANTIBODIES;
   DISEASE; MARKERS; INFECTIONS
AB AimThis investigation explored the relationship between oral bacteria and metabolic syndrome (METS). Materials and MethodsThere were 4,882 subjects enrolled in this cross-sectional study from the NHANES III database. The severity of periodontitis was classified into mild, moderate and severe. We measured oral bacterial antibodies. We examined the relationship between serum immunoglobulin G (IgG) antibodies of oral bacteria and METS via performing multivariate regression analysis. Mediation analysis of oral bacteria on the correlation between periodontitis and METS was also executed. ResultsAfter adjusting for covariates, the serum IgG antibodies of P. nigrescens, E. corrodens, and E. nodatum were associated with the presence of METS (p = 0.006, p = 0.014 and p = 0.018, respectively). Furthermore, serum IgG antibodies of P. intermedia, T. forsythia and V. parvula were positively associated with the presence of METS (p = 0.001, p = 0.011, and p = 0.002, respectively) and >= 4 features of METS (p = 0.019, p = 0.025, and p = 0.02, respectively). P. intermedia IgG mediated 11.2% of the relationship between periodontitis and METS. ConclusionSerological markers of oral pathogens were correlated with the presence and the number of METS features after multivariable adjustment. Oral bacteria acted as a mediator of the correlation between periodontitis and METS. Our study provided a biologically plausible explanation for the association between periodontitis and METS, which provides a comprehensive evaluation of periodontitis.
C1 [Yang, Zhe-Yu; Fang, Wen-Hui; Chen, Wei-Liang] Triserv Gen Hosp, Sch Med, Dept Family & Community Med, Div Family Med, Taipei, Taiwan.
   [Yang, Zhe-Yu; Fang, Wen-Hui; Chen, Wei-Liang] Natl Def Med Ctr, Sch Med, Taipei, Taiwan.
   [Fang, Wen-Hui; Chen, Wei-Liang] Triserv Gen Hosp Taipei, Dept Family & Community Med, Div Geriatr Med, Taipei, Taiwan.
   [Kao, Chia-Chun] Taipei Vet Gen Hosp, Dept Med Educ, Taipei, Taiwan.
   [Chen, Wei-Liang] Natl Def Med Ctr, Dept Biochem, Taipei, Taiwan.
C3 Tri-Service General Hospital; National Defense Medical Center; Taipei
   Veterans General Hospital; National Defense Medical Center
RP Chen, WL (corresponding author), Triserv Gen Hosp, Sch Med, Dept Family & Community Med, Div Family Med, Taipei, Taiwan.; Chen, WL (corresponding author), Natl Def Med Ctr, Sch Med, Taipei, Taiwan.; Chen, WL (corresponding author), Triserv Gen Hosp Taipei, Dept Family & Community Med, Div Geriatr Med, Taipei, Taiwan.; Chen, WL (corresponding author), Natl Def Med Ctr, Dept Biochem, Taipei, Taiwan.
EM weiliang0508@gmail.com
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NR 50
TC 0
Z9 0
U1 0
U2 2
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 2296-858X
J9 FRONT MED-LAUSANNE
JI Front. Med.
PD JUL 22
PY 2022
VL 9
AR 899063
DI 10.3389/fmed.2022.899063
PG 11
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 3P0DG
UT WOS:000837205400001
PM 35935796
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Litterio, MC
   Prieto, MAV
   Adamo, AM
   Elesgaray, R
   Oteiza, PI
   Galleano, M
   Fraga, CG
AF Litterio, Maria C.
   Vazquez Prieto, Marcela A.
   Adamo, Ana M.
   Elesgaray, Rosana
   Oteiza, Patricia I.
   Galleano, Monica
   Fraga, Cesar G.
TI (-)-Epicatechin reduces blood pressure increase in high-fructose-fed
   rats: effects on the determinants of nitric oxide bioavailability
SO JOURNAL OF NUTRITIONAL BIOCHEMISTRY
LA English
DT Article
DE Flavonoids; Fructose; Hypertension; Metabolic syndrome; Oxidants;
   Superoxide anion
ID NADPH OXIDASE; OXIDATIVE STRESS; ANGIOTENSIN-II; INSULIN-RESISTANCE;
   ENDOTHELIAL DYSFUNCTION; METABOLIC SYNDROME; VASCULAR-DISEASE;
   PROTEIN-KINASES; ACTIVATION; SYNTHASE
AB This work investigated the blood pressure (BP)-lowering effect of the flavanol (-)-epicatechin in a model of metabolic syndrome. Rats were fed a regular chow diet without (Control) or with 10% (w/v) fructose in the drinking water (high fructose, HF) for 8 weeks. A subgroup of the HF-fed rats was supplemented with (-)-epicatechin 20 mg/kg body weight (HF-EC). Dietary (-)-epicatechin reverted the increase in BP caused by the fructose treatment. In aorta, superoxide anion production and the expression of the NADPH oxidase (NOX) subunits p47(Phox) and p22(Phox) were enhanced in the HF-fed rats. The increase was prevented by (-)-epicatechin. Similar profile was observed for NOX4 expression. The activity of aorta nitric oxide synthase (NOS) was increased in the HF group and was even higher in the HF-EC rats. These effects were paralleled by increased endothelial NOS phosphorylation at the activation site Ser1177. Among the more relevant mitogen-activated protein kinase pathways in vascular tissue, c-Jun-N-terminal kinase was shown to be activated in the aorta of the HF-fed rats, and (-)-epicatechin supplementation mitigated this activation.
   Thus, the results suggest that dietary (-)-epicatechin supplementation prevented hypertension in HF-fed rats, decreasing superoxide anion production and elevating NOS activity, favoring an increase in NO bioavailability. (C) 2015 Elsevier Inc. All rights reserved.
C1 [Litterio, Maria C.; Galleano, Monica; Fraga, Cesar G.] Univ Buenos Aires, CONICET, Sch Pharm & Biochem, Phys Chem,Inst Mol Biochem & Mol Med IBIMOL, RA-1053 Buenos Aires, DF, Argentina.
   [Vazquez Prieto, Marcela A.] Natl Univ Cuyo, Sch Med, Dept Pathol, Mendoza, Argentina.
   [Vazquez Prieto, Marcela A.] Consejo Nacl Invest Cient & Tecn, Inst Med & Expt Biol, Mendoza, Argentina.
   [Adamo, Ana M.] Univ Buenos Aires, CONICET, Sch Pharm & Biochem, Dept Biol Chem IQUIFIB, RA-1053 Buenos Aires, DF, Argentina.
   [Elesgaray, Rosana] Univ Buenos Aires, CONICET, Sch Pharm & Biochem, Physiol Inst Drug Chem & Metab IQUIMEFA, RA-1053 Buenos Aires, DF, Argentina.
   [Oteiza, Patricia I.] Univ Calif Davis, Dept Nutr, Davis, CA 95616 USA.
   [Oteiza, Patricia I.] Univ Calif Davis, Dept Environm Toxicol, Davis, CA 95616 USA.
C3 University of Buenos Aires; Consejo Nacional de Investigaciones
   Cientificas y Tecnicas (CONICET); University Nacional Cuyo Mendoza;
   Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET);
   University of Buenos Aires; Consejo Nacional de Investigaciones
   Cientificas y Tecnicas (CONICET); University of Buenos Aires; Consejo
   Nacional de Investigaciones Cientificas y Tecnicas (CONICET); University
   of California System; University of California Davis; University of
   California System; University of California Davis
RP Galleano, M (corresponding author), Univ Buenos Aires, CONICET, Sch Pharm & Biochem, Phys Chem,Inst Mol Biochem & Mol Med IBIMOL, RA-1053 Buenos Aires, DF, Argentina.
EM mgallean@ffyb.uba.ar
RI Prieto, Marcela/W-4291-2019; Fraga, Cesar/Q-8161-2019; Adamo,
   Ana/U-7961-2019
OI Fraga, Cesar G./0000-0003-4168-9927
FU Universidad de Buenos Aires (UBACyT) [20020130100760BA, 20020120100177,
   20020120100132]; Consejo Nacional de Investigaciones Cientificas y
   Tecnologicas (CONICET) [PIP-0612]; Agencia Nacional de Promocion
   Cientifica y Tecnologica [ANPCyT BID PICT 2012-0765, 2011-1957]
FX This study was supported by grants from the Universidad de Buenos Aires
   (UBACyT 20020130100760BA, 20020120100177, 20020120100132), Consejo
   Nacional de Investigaciones Cientificas y Tecnologicas (CONICET)
   (PIP-0612) and Agencia Nacional de Promocion Cientifica y Tecnologica
   (ANPCyT BID PICT 2012-0765, 2011-1957).
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NR 58
TC 42
Z9 45
U1 0
U2 14
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0955-2863
EI 1873-4847
J9 J NUTR BIOCHEM
JI J. Nutr. Biochem.
PD JUL
PY 2015
VL 26
IS 7
BP 745
EP 751
DI 10.1016/j.jnutbio.2015.02.004
PG 7
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA CK9LM
UT WOS:000356561600008
PM 25943039
OA Green Published
DA 2025-06-11
ER

PT J
AU Meneses, ME
   Camargo, A
   Perez-Martinez, P
   Delgado-Lista, J
   Cruz-Teno, C
   Jimenez-Gomez, Y
   Paniagua, JA
   Gutierrez-Mariscal, FM
   Tinahones, FJ
   Vidal-Puig, A
   Roche, HM
   Perez-Jimenez, F
   Malagon, MM
   Lopez-Miranda, J
AF Meneses, Maria E.
   Camargo, Antonio
   Perez-Martinez, Pablo
   Delgado-Lista, Javier
   Cruz-Teno, Cristina
   Jimenez-Gomez, Yolanda
   Paniagua, Juan A.
   Gutierrez-Mariscal, Francisco M.
   Tinahones, Francisco J.
   Vidal-Puig, Antonio
   Roche, Helen M.
   Perez-Jimenez, Francisco
   Malagon, Maria M.
   Lopez-Miranda, Jose
TI Postprandial inflammatory response in adipose tissue of patients with
   metabolic syndrome after the intake of different dietary models
SO MOLECULAR NUTRITION & FOOD RESEARCH
LA English
DT Article
DE Adipose tissue; Diet; Inflammation; Metabolic syndrome; Postprandial
   state
ID ENDOPLASMIC-RETICULUM STRESS; BLOOD MONONUCLEAR-CELLS; FACTOR-KAPPA-B;
   MACROPHAGE ACCUMULATION; OLIVE OIL; ACTIVATION; ADIPONECTIN; EXPRESSION;
   LEUKOCYTES; LIPEMIA
AB Scope: Dysfunctional adipose tissue may be an important trigger of molecular inflammatory pathways that cause cardiovascular diseases. Our aim was to determine whether the specific quality and quantity of dietary fat produce differential postprandial inflammatory responses in adipose tissue from metabolic syndrome (MetS) patients.
   Methods and results: A randomized, controlled trial conducted within the LIPGENE study assigned MetS patients to 1 of 4 diets: (i) high-saturated fatty acid (HSFA), (ii) high-monounsaturated fatty acid (HMUFA), (iii) low-fat, high-complex carbohydrate diet supplemented with n-3 polyunsaturated fatty acids (PUFA) (LFHCC n-3), and (iv) low-fat, high-complex carbohydrate diet supplemented with placebo (LFHCC), for 12 wk each. A fat challenge reflecting the fatty acid composition as the original diets was conducted post-intervention. We found that p65 gene expression is induced in adipose tissue (p50.003) at the postprandial state. In addition, I kappa Ba (p<0.001), MCP-1 (p<0.001) and IL-1 beta (p<0.001) gene expression was equally induced in the postprandial state, regardless of the quality and quantity of the dietary fat. Notably, IL-6 transcripts were only detected in the postprandial state.
   Conclusions: Our results indicate that individuals with MetS typically exhibit exacerbated adipose tissue postprandial inflammatory responses, which seem to be independent of the quality and quantity of dietary fat.
C1 [Meneses, Maria E.; Camargo, Antonio; Perez-Martinez, Pablo; Delgado-Lista, Javier; Cruz-Teno, Cristina; Paniagua, Juan A.; Perez-Jimenez, Francisco; Lopez-Miranda, Jose] Univ Cordoba, Reina Sofia Univ Hosp, IMIBIC, Lipids & Atherosclerosis Unit, E-14004 Cordoba, Spain.
   [Meneses, Maria E.; Camargo, Antonio; Perez-Martinez, Pablo; Delgado-Lista, Javier; Cruz-Teno, Cristina; Paniagua, Juan A.; Gutierrez-Mariscal, Francisco M.; Tinahones, Francisco J.; Perez-Jimenez, Francisco; Lopez-Miranda, Jose] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr CIBEROBN, Cordoba, Spain.
   [Jimenez-Gomez, Yolanda; Malagon, Maria M.] Univ Cordoba, Dept Cell Biol Physiol & Immunol, E-14004 Cordoba, Spain.
   [Gutierrez-Mariscal, Francisco M.; Tinahones, Francisco J.] Hosp Univ Virgen de la Victoria, Malaga, Spain.
   [Vidal-Puig, Antonio] Univ Cambridge, Inst Metab Sci, Metab Res Labs, Cambridge, England.
   [Roche, Helen M.] Univ Coll Dublin, UCD Conway Inst Biomol & Biomed Res, Sch Publ Hlth, Nutrigen Res Grp, Dublin 2, Ireland.
C3 Universidad de Cordoba; Hospital Universitario Reina Sofia - Cordoba;
   Instituto de Salud Carlos III; CIBER - Centro de Investigacion Biomedica
   en Red; CIBEROBN; Universidad de Cordoba; Hospital Virgen de la
   Victoria; Universidad de Malaga; University of Cambridge; University
   College Dublin
RP Lopez-Miranda, J (corresponding author), Univ Cordoba, Reina Sofia Univ Hosp, IMIBIC, Lipids & Atherosclerosis Unit, Avda Menendez Pidal S-N, E-14004 Cordoba, Spain.
EM jlopezmir@uco.es
RI Jimenez, Francisco/AAJ-9559-2021; Delgado-Lista, Javier/KAM-7412-2024;
   Mariscal, Francisco/AAH-3689-2020; Lopez-Miranda, Jose/Y-8306-2019;
   Tinahones, Francisco/AAB-2882-2020; Jimenez-Gomez, Yolanda/Y-3742-2018;
   Meneses, Maria E./Q-2572-2018; Perez Martinez, Pablo/AEL-6176-2022;
   MALAGON, MARIA M/L-5386-2014; Camargo Garcia, Antonio/G-9720-2015;
   Gutierrez Mariscal, Francisco Miguel/F-9804-2016
OI Jimenez-Gomez, Yolanda/0000-0002-1607-2717; Meneses, Maria
   E./0000-0002-7689-7024; Tinahones, Francisco J/0000-0001-6871-4403;
   Vidal-Puig, Antonio/0000-0003-4220-9577; Delgado Lista, Francisco
   Javier/0000-0002-2982-2716; Perez Jimenez,
   Francisco/0000-0001-9808-1280; Perez Martinez,
   Pablo/0000-0001-7716-8117; Perez-Jimenez, Francisco/0000-0001-7499-7681;
   Roche, Helen/0000-0002-0628-3318; Lopez-Miranda,
   Jose/0000-0002-8844-0718; MALAGON, MARIA M/0000-0002-2419-2727; , Juan
   A. Paniagua/0000-0003-2892-980X; Camargo Garcia,
   Antonio/0000-0002-0415-4184; Gutierrez Mariscal, Francisco
   Miguel/0000-0003-3353-2188
FU European Union (LIPGENE) from the Ministerio de Ciencia e Innovacion
   [505944, AGL2004-07907, AGL2006-01979, AGL2009-12270]; CIBER
   Fisiopatologia de la Obesidad y Nutricion [CB06/03/0047]; Consejeria de
   Innovacion, Ciencia y Empresa, Junta de Andalucia [P06-CTS-01425,
   CTS-03039]; Consejeria de Salud, Junta de Andalucia [06/128, 07/43,
   PI-0193]; Fondo Europeo de Desarrollo Regional (FEDER); Consejo Nacional
   de Ciencia y Tecnologia, Mexico. (CONACYT)
FX This work was supported in part by research grants from the European
   Union (LIPGENE European Integrated Project-505944), from the Ministerio
   de Ciencia e Innovacion (grant numbers AGL2004-07907, AGL2006-01979,
   AGL2009-12270 (to J. L.-M.)); CIBER Fisiopatologia de la Obesidad y
   Nutricion (grant number CB06/03/0047); Consejeria de Innovacion, Ciencia
   y Empresa, Junta de Andalucia (grant number P06-CTS-01425 (to J. L.-M.)
   CTS-03039 (to MMM)); and Consejeria de Salud, Junta de Andalucia (grant
   numbers 06/128, 07/43, PI-0193 (to J. L.-M.)); Fondo Europeo de
   Desarrollo Regional (FEDER). The CIBEROBN is an initiative of the
   Instituto de Salud Carlos III, Madrid, Spain; MEM has a fellowship by
   Consejo Nacional de Ciencia y Tecnologia, Mexico. (CONACYT). We thank to
   M<SUP>a</SUP> Jose Gomez-Luna for technical support.
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NR 43
TC 48
Z9 50
U1 0
U2 20
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1613-4125
EI 1613-4133
J9 MOL NUTR FOOD RES
JI Mol. Nutr. Food Res.
PD DEC
PY 2011
VL 55
IS 12
BP 1759
EP 1770
DI 10.1002/mnfr.201100200
PG 12
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA 855RM
UT WOS:000297581900002
PM 22144044
DA 2025-06-11
ER

PT J
AU Behl, T
   Gupta, A
   Chigurupati, S
   Singh, S
   Sehgal, A
   Badavath, VN
   Alhowail, A
   Mani, V
   Bhatia, S
   Al-Harrasi, A
   Bungau, S
AF Behl, Tapan
   Gupta, Amit
   Chigurupati, Sridevi
   Singh, Sukhbir
   Sehgal, Aayush
   Badavath, Vishnu Nayak
   Alhowail, Ahmad
   Mani, Vasudevan
   Bhatia, Saurabh
   Al-Harrasi, Ahmed
   Bungau, Simona
TI Natural and Synthetic Agents Targeting Reactive Carbonyl Species against
   Metabolic Syndrome
SO MOLECULES
LA English
DT Review
DE reactive carbonyls species; advanced glycation end products;
   sequestering agents; advanced lipo-oxidation end products; metabolism;
   metabolic syndrome
ID GLYCATION END-PRODUCTS; SALT-SENSITIVE HYPERTENSION; VITAMIN-E
   SUPPLEMENTATION; INDUCED OXIDATIVE STRESS; CARDIOVASCULAR-DISEASE;
   L-CARNOSINE; PROTEIN CARBONYLATION; MOLECULAR-MECHANISMS;
   INSULIN-RESISTANCE; DIABETES-MELLITUS
AB Reactive carbonyl species (RCS) may originate from the oxidation of unsaturated fatty acids and sugar in conditions of pathology. They are known to have high reactivity towards DNA as well as nucleophilic sites of proteins, resulting in cellular dysfunction. It has been considered that various pathological conditions are associated with an increased level of RCS and their reaction products. Thus, regulating the levels of RCS may be associated with the mitigation of various metabolic and neurodegenerative disorders. In order to perform a comprehensive review, various literature databases, including MEDLINE, EMBASE, along with Google Scholar, were utilized to obtain relevant articles. The voluminous review concluded that various synthetic and natural agents are available or in pipeline research that hold tremendous potential to be used as a drug of choice in the therapeutic management of metabolic syndrome, including obesity, dyslipidemia, diabetes, and diabetes-associated complications of atherosclerosis, neuropathy, and nephropathy. From the available data, it may be emphasized that various synthetic agents, such as carnosine and simvastatin, and natural agents, such as polyphenols and terpenoids, can become a drug of choice in the therapeutic management for combating metabolic syndromes that involve RCS in their pathophysiology. Since the RCS are known to regulate the biological processes, future research warrants detailed investigations to decipher the precise mechanism.
C1 [Behl, Tapan; Gupta, Amit; Singh, Sukhbir; Sehgal, Aayush; Badavath, Vishnu Nayak] Chitkara Univ, Chitkara Coll Pharm, Rajpura 140401, India.
   [Chigurupati, Sridevi] Qassim Univ, Coll Pharm, Dept Med Chem & Pharmacognosy, Buraydah, Saudi Arabia.
   [Alhowail, Ahmad; Mani, Vasudevan] Qassim Univ, Coll Pharm, Dept Pharmacol & Toxicol, Buraydah 51452, Saudi Arabia.
   [Bhatia, Saurabh; Al-Harrasi, Ahmed] Univ Nizwa, Nat & Med Sci Res Ctr, Nizwa POB 33, Birkat Al Mauz, Oman.
   [Bhatia, Saurabh] Univ Petr & Energy Studies, Sch Hlth Sci, Dehra Dun 248007, Uttarakhand, India.
   [Bungau, Simona] Univ Oradea, Fac Med & Pharm, Dept Pharm, Oradea 410073, Romania.
   [Bungau, Simona] Univ Oradea, Doctoral Sch Biomed Sci, Oradea 410087, Romania.
C3 Chitkara University, Punjab; Qassim University; Qassim University;
   University of Nizwa; University of Petroleum & Energy Studies (UPES);
   University of Oradea; University of Oradea
RP Behl, T (corresponding author), Chitkara Univ, Chitkara Coll Pharm, Rajpura 140401, India.; Bungau, S (corresponding author), Univ Oradea, Fac Med & Pharm, Dept Pharm, Oradea 410073, Romania.; Bungau, S (corresponding author), Univ Oradea, Doctoral Sch Biomed Sci, Oradea 410087, Romania.
EM tapanbehl31@gmail.com; amitgupta2508@gmail.com; s.chigurupati@qu.edu.sa;
   sukhbir.singh@chitkara.edu.in; aayushsehgal00@gmail.com;
   vishnu.badavath@chitkara.edu.in; aalhowail@qu.edu.sa; v.samy@qu.edu.sa;
   sbsaurabhbhatia@gmail.com; aharrasi@unizwa.edu.om;
   simonabungau@gmail.com
RI Singh, Dr. Sukhbir/AAZ-7468-2020; Ul-Hamid, Anwar/B-7297-2015; Bungau,
   Simona Gabriela/C-1831-2015; Mani, Vasudevan/H-6371-2013; Badavath, Dr.
   Vishnu Nayak/H-2671-2016; CHIGURUPATI, SRIDEVI/GRX-8274-2022
OI Gupta, Amit/0000-0002-5447-9980; Mani, Vasudevan/0000-0002-8440-8366;
   Badavath, Dr. Vishnu Nayak/0000-0002-6433-2691; Singh,
   Sukhbir/0000-0003-0692-7002; CHIGURUPATI, SRIDEVI/0000-0002-1081-2964
FU University of Oradea, Oradea, Romania
FX Funding for the publication of this paper is provided by the University
   of Oradea, Oradea, Romania, by an Internal project.
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NR 152
TC 11
Z9 11
U1 1
U2 15
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1420-3049
J9 MOLECULES
JI Molecules
PD MAR
PY 2022
VL 27
IS 5
AR 1583
DI 10.3390/molecules27051583
PG 29
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 0A1IX
UT WOS:000773716300001
PM 35268685
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Rasaee, S
   Alizadeh, M
   Kheirouri, S
   Abdollahzad, H
AF Rasaee, Sama
   Alizadeh, Mohammad
   Kheirouri, Sorayya
   Abdollahzad, Hadi
TI Does total antioxidant capacity affect the features of metabolic
   syndrome? A systematic review
SO NUTRITION & FOOD SCIENCE
LA English
DT Review
DE Blood pressure; Metabolic syndrome; Dietary total antioxidant capacity;
   Dyslipidemia; High-density lipoprotein; Insulin resistance
ID OXIDATIVE STRESS; HEALTH; RISK; DIET; DISEASE; INFLAMMATION; OBESITY
AB Purpose
   There is some evidence that suggest a higher dietary total antioxidant capacity (DTAC) is associated with a lower risk of metabolic syndrome (MetS). Considering the conflicting results in this field, this paper aims to provide a comprehensive summary of studies on the association of DTAC and components of MetS.
   Design/methodology/approach
   A systematic review of articles indexed in PubMed, Scopus and Google Scholar, published from inception to September 2018, with defined keywords, was done. Duplicate or irrelevant reports were screened out and data were extracted through critical analysis. Finally, among the 353 articles, 19 articles met the inclusion criteria.
   Findings
   The included cohort studies revealed that higher DTAC was associated with reduced risk of MetS. Also, the association between DTAC and mortality risk of MetS was insignificant in these studies. The case-control studies showed high DTAC is inversely associated with MetS, its components and complications. The randomized controlled trials found that changes in DTAC were negatively correlated with oxidized low-density lipoprotein cholesterol and there was a positive association between DTAC and subjects' weight and body mass index. Finally, results from the cross-sectional studies were inconsistence in this regard.
   Originality/value
   The assessed relationship between MetS or its components with DTAC is inconsistent in the included studies. Different sample size, dietary assessment tools, DTAC index values and geographical location may justify the observed inconsistencies. It seems that further studies are needed to reveal more confident and reliable findings.
C1 [Rasaee, Sama; Alizadeh, Mohammad; Kheirouri, Sorayya] Tabriz Univ Med Sci, Fac Nutr & Food Sci, Nutr Res Ctr, Tabriz, Iran.
   [Abdollahzad, Hadi] Kermanshah Univ Med Sci, Nutr Res Ctr, Fac Nutr & Food Sci, Kermanshah, Iran.
C3 Tabriz University of Medical Science; Kermanshah University of Medical
   Sciences
RP Alizadeh, M (corresponding author), Tabriz Univ Med Sci, Fac Nutr & Food Sci, Nutr Res Ctr, Tabriz, Iran.
EM sama3319@yahoo.com; Md_alizadeh@yahoo.com; kheirouris@tbzmed.ac.ir;
   hadi_nut@yahoo.com
RI abdollahzad, hadi/J-9093-2017; Alizadeh, Mohammad/M-4703-2017
OI Abdollahzad, Hadi/0000-0003-2367-9573; kheirouri,
   sorayya/0000-0001-6249-4462
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NR 66
TC 7
Z9 7
U1 0
U2 9
PU EMERALD GROUP PUBLISHING LTD
PI Leeds
PA Floor 5, Northspring 21-23 Wellington Street, Leeds, W YORKSHIRE,
   ENGLAND
SN 0034-6659
EI 1758-6917
J9 NUTR FOOD SCI
JI Nutr. Food Sci.
PD JAN 27
PY 2021
VL 51
IS 1
BP 100
EP 113
DI 10.1108/NFS-01-2020-0031
EA MAY 2020
PG 14
WC Food Science & Technology
WE Emerging Sources Citation Index (ESCI)
SC Food Science & Technology
GA PZ9ZR
UT WOS:000532268800001
DA 2025-06-11
ER

PT J
AU Tamtaji, OR
   Milajerdi, A
   Dadgostar, E
   Kolandooz, F
   Chamani, M
   Amirani, E
   Mirzaei, H
   Asemi, Z
AF Tamtaji, Omid R.
   Milajerdi, Alireza
   Dadgostar, Ehsan
   Kolandooz, Fariba
   Chamani, Maryam
   Amirani, Elaheh
   Mirzaei, Hamed
   Asemi, Zatollah
TI The Effects of Quercetin Supplementation on Blood Pressures and
   Endothelial Function Among Patients with Metabolic Syndrome and Related
   Disorders: A Systematic Review and Meta-analysis of Randomized
   Controlled Trials
SO CURRENT PHARMACEUTICAL DESIGN
LA English
DT Review
DE Quercetin; blood pressures; endothelial function; meta-analysis;
   randomized controlled trials; metabolic syndrome
ID ADHESION MOLECULE EXPRESSION; LOW-DENSITY-LIPOPROTEIN; ONION SKIN
   EXTRACT; OXIDATIVE STRESS; CARDIOVASCULAR-DISEASE; DOUBLE-BLIND;
   KAPPA-B; DYSFUNCTION; INHIBITION; MEN
AB Background: This systematic review and meta-analysis of randomized controlled trials (RCTs) were performed to determine the effect of quercetin administration on blood pressures and endothelial function among patients with metabolic syndrome (MetS) and related disorders.
   Methods: We searched systematically online databases including Cochrane Library. EMBASE, MEDLINE, and Web of Science to identify the relevant RCTs until December 2018. Q-test and I-2 statistics were applied to assess heterogeneity among the included studies. Data were pooled using a random-effects model and weighted mean difference (WMD) was considered as the overall effect size.
   Results: Out of 284 citations, 8 RCTs were included in the meta-analysis. We found a significant reduction in systolic blood pressure (SBP) (WMD: -1.69; 95% CI: -3.22, -0.17) following the intake of quercetin supplements. However, quercetin supplementation did not significantly affect diastolic blood pressure (DBP) (WMD: -3.14; 95% CI: -8.24, 1.95), vascular cell adhesion molecule 1 (VCAM-1) (WMD: -24.49; 95% CI: -53.74, 4.77) and intercellular adhesion molecule 1 (ICAM-1) (WMD: -5.78; 95% CI: -12.93, 1.38).
   Conclusion: In summary, the current meta-analysis demonstrated that quercetin supplementation significantly reduced SBP, yet did not affect DBP, VCAM-1 and ICAM-1 among patients with MetS and related disorders.
C1 [Tamtaji, Omid R.; Amirani, Elaheh; Mirzaei, Hamed; Asemi, Zatollah] Kashan Univ Med Sci, Res Ctr Biochem & Nutr Metab Dis, Kashan, Iran.
   [Milajerdi, Alireza] Univ Tehran Med Sci, Students Sci Res Ctr, Tehran, Iran.
   [Milajerdi, Alireza] Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Community Nutr, Tehran, Iran.
   [Dadgostar, Ehsan] FDA, Halal Res Ctr IRI, Tehran, Iran.
   [Kolandooz, Fariba] Univ Alberta, Dept Med, Indigenous & Global Hlth Res, Edmonton, AB, Canada.
   [Chamani, Maryam] Iran Univ Med Sci, Sch Med, Dept Gynecol & Obstet, Tehran, Iran.
C3 Tehran University of Medical Sciences; Tehran University of Medical
   Sciences; University of Alberta; Iran University of Medical Sciences
RP Asemi, Z (corresponding author), Kashan Univ Med Sci, Res Ctr Biochem & Nutr Metab Dis, Kashan, Iran.
EM asemi_r@yahoo.com
RI tamtaji, M/KWU-3655-2024; Milajerdi, Alireza/ABB-1854-2020; Asemi,
   Zatollah/G-7393-2017; Chamani, Maryam/Y-3396-2019
OI Tamtaji, Omid Reza/0000-0003-2492-3996; dadgostar,
   ehsan/0000-0002-4041-7324
FU Kashan University of Medical Sciences (KAUMS) [97201]
FX The research grant (97201) was provided by the Research Deputy of Kashan
   University of Medical Sciences (KAUMS).
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NR 40
TC 25
Z9 25
U1 2
U2 10
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1381-6128
EI 1873-4286
J9 CURR PHARM DESIGN
JI Curr. Pharm. Design
PY 2019
VL 25
IS 12
BP 1372
EP 1384
DI 10.2174/1381612825666190513095352
PG 13
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA IQ0AU
UT WOS:000480413100002
PM 31092175
DA 2025-06-11
ER

PT J
AU Ebrahimi-Mameghani, M
   Asghari-Jafarabadi, M
   Rezazadeh, K
AF Ebrahimi-Mameghani, Mehranghiz
   Asghari-Jafarabadi, Mohammad
   Rezazadeh, Khatereh
TI TCF7L2-rs7903146 polymorphism modulates the effect of artichoke leaf
   extract supplementation on insulin resistance in metabolic syndrome: a
   randomized, double-blind, placebo-controlled trial
SO JOURNAL OF INTEGRATIVE MEDICINE-JIM
LA English
DT Article
DE Metabolic syndrome; Artichoke leaf extract; Transcription factor 7-like
   2; Insulin; Insulin resistance; Alternative and complementary medicine;
   Diabetes
ID CYNARA-SCOLYMUS L.; BETA-CELL FUNCTION; PLASMA-CHOLESTEROL; OXIDATIVE
   STRESS; GENETIC-VARIANTS; CLINICAL-TRIAL; IN-VIVO; TCF7L2; RISK;
   PRETREATMENT
AB Background: Transcription factor 7-like 2 (TCF7L2)-rs7903146 polymorphism is associated with increased risk of type 2 diabetes. The response of insulin and insulin resistance to artichoke leaf extract (ALE) may be affected by TCF7L2-rs7903146 polymorphism.
   Objective: This study examined the effects of ALE supplementation on metabolic parameters of the TCF7L2-rs7903146 polymorphism in patients with metabolic syndrome (MetS).
   Design, setting, participants and interventions: This double-blind clinical trial was conducted on 80 patients with MetS in Sina Clinic, Khoy, Iran. The patients were randomized into ALE or placebo groups to receive either ALE (1800 mg/d as four tablets) or matching placebo for 12 weeks.
   Main outcome measures: Anthropometric indices, blood pressure, glucose and lipid profile levels were measured before and after the study. Moreover, patients were genotyped for TCF7L2 polymorphism.
   Results: ALE supplementation decreased insulin level and the homeostasis model assessment of insulin resistance (HOMA-IR) in patients with the TT genotype of TCF7L2-rs7903146 polymorphism (P < 0.05). There was no significant interaction between blood pressure, glucose and lipid profile response to ALE supplementation.
   Conclusion: The responses of insulin and HOMA-IR to ALE supplementation have shown an interaction with single-nucleotide polymorphism rs7903146 in TCF7L2. (C) 2018 Shanghai Changhai Hospital. Published by Elsevier B.V. All rights reserved.
C1 [Ebrahimi-Mameghani, Mehranghiz; Rezazadeh, Khatereh] Tabriz Univ Med Sci, Sch Nutr & Food Sci, Nutr Res Ctr, Tabriz 5166614711, Iran.
   [Asghari-Jafarabadi, Mohammad] Tabriz Univ Med Sci, Rd Traff Injury Res Ctr, Tabriz 5166614711, Iran.
   [Asghari-Jafarabadi, Mohammad] Tabriz Univ Med Sci, Sch Hlth, Dept Stat & Epidemiol, Tabriz 5166614711, Iran.
   [Rezazadeh, Khatereh] Tabriz Univ Med Sci, Sch Nutr & Food Sci, Student Res Comm, Tabriz, Iran.
C3 Tabriz University of Medical Science; Tabriz University of Medical
   Science; Tabriz University of Medical Science; Tabriz University of
   Medical Science
RP Rezazadeh, K (corresponding author), Tabriz Univ Med Sci, Sch Nutr & Food Sci, Nutr Res Ctr, Tabriz 5166614711, Iran.
EM rezazadekhatere@gmail.com
RI Rezazadeh, Khatereh/N-2488-2019; Asghari Jafarabadi,
   Mohammmad/A-7478-2017
OI Asghari Jafarabadi, Mohammmad/0000-0003-3284-9749; rezazadeh,
   khatereh/0000-0002-9270-7788
FU Research Vice Chancellor, Tabriz University of Medical Sciences, Tabriz,
   Iran [5/97/4653]
FX We are grateful to the subjects who have contributed in this study. We
   also would like to acknowledge Dineh Iran. Co. for preparing of ALE and
   placebo tablets. This study was supported by a Grant from the Research
   Vice Chancellor, Tabriz University of Medical Sciences, Tabriz, Iran
   (grant number: 5/97/4653). The results of this article are derived from
   the Ph.D. thesis of Khatereh Rezazadeh (NO, D/41).
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NR 46
TC 29
Z9 29
U1 1
U2 3
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2095-4964
J9 J INTEGR MED-JIM
JI J. Integr. Med.-JIM
PD SEP
PY 2018
VL 16
IS 5
BP 329
EP 334
DI 10.1016/j.joim.2018.05.006
PG 6
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA GS2BV
UT WOS:000443346100005
PM 30177026
DA 2025-06-11
ER

PT J
AU Chao, PM
   Kuo, YH
   Lin, YS
   Chen, CH
   Chen, SW
   Kuo, YH
AF Chao, Pei-Min
   Kuo, Yueh-Hsiung
   Lin, Yu-Shun
   Chen, Chi-Hua
   Chen, Shiow-Wen
   Kuo, Yao-Haur
TI The Metabolic Benefits of Polygonum hypoleucum Ohwi in HepG2
   Cells and Wistar Rats under Lipogenic Stress
SO JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
LA English
DT Article
DE Acetyl-CoA carboxylase; P. hypoleucum Ohwl; lipogenic condition;
   metabolic syndrome
ID TRIGLYCERIDE TRANSFER PROTEIN; ACETYL-COA CARBOXYLASE; HEPATIC
   INSULIN-RESISTANCE; FATTY-ACID OXIDATION; FRUCTOSE-FED HAMSTER;
   HEPATOCYTE APO-B; GENE-EXPRESSION; FISH-OIL; MICE; SECRETION
AB Inhibition of acetyl-CoA carboxylase (ACC) is one approach used for treating metabolic syndrome. Using partially purified ACC to screen herbs commonly used in Taiwanese folk medicine, we previously showed that an ethanol extract of Polygonum hypoleucum Ohwi (EP) had potent ACC inhibitory activity and partially alleviated metabolic disorders induced by a high fat diet. Since ACC plays a crucial role in de novo lipogenesis, the favorable effects of EP on metabolism were tested under lipogenic conditions in the present study. On incubating high glucose (30 mM)-stimulated HepG2 cells with EP (72.5 or 145 mu g/mL), ACC and fatty acid synthase activity, triacylglycerol content, and microsomal triacylglycerol transfer protein mRNA levels were all significantly reduced (P < 0.05, vs vehicle). When EP was given at low, medium, and high dosages (94, 188, and 470 mg/kg) to sucrose water-treated Wistar rats for four weeks, alleviation of symptoms associated with metabolic syndrome, including obesity, insulin resistance, hypertriglyceridemia, and hypertension, accompanied by hepatic ACC inactivation, was seen in the low dosage group. Four compounds (emodin, emodin-8-O-beta-D-glucopyranoside, (+)-catechin, and (-)-epicatechin) isolated from EP were identified as ACC inhibitors. These results confirm that P. hypoleucum Ohwi, acting partly through ACC inhibition, has favorable effects in alleviating metabolic disturbances occurring under lipogenic conditions.
C1 [Chao, Pei-Min; Lin, Yu-Shun] China Med Univ, Inst Nutr, Taichung 404, Taiwan.
   [Kuo, Yueh-Hsiung] China Med Univ, Tsuzuki Inst Tradit Med, Taichung 404, Taiwan.
   [Kuo, Yueh-Hsiung] Natl Taiwan Univ, Dept Chem, Taipei 106, Taiwan.
   [Kuo, Yueh-Hsiung] Acad Sinica, Taipei 115, Taiwan.
   [Chen, Chi-Hua; Chen, Shiow-Wen] Food Ind Res Dev Inst, Hsinchu 300, Taiwan.
   [Kuo, Yao-Haur] Natl Res Inst Chinese Med, Taipei 112, Taiwan.
C3 China Medical University Taiwan; China Medical University Taiwan;
   National Taiwan University; Academia Sinica - Taiwan; National Research
   Institute of Chinese Medicine
RP Chao, PM (corresponding author), China Med Univ, Inst Nutr, Taichung 404, Taiwan.
EM pmchao@mail.cmu.edu.tw
RI chao, P/GSD-8001-2022
OI Chao, Pei-Min/0000-0002-4846-3245
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NR 39
TC 18
Z9 19
U1 0
U2 9
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0021-8561
J9 J AGR FOOD CHEM
JI J. Agric. Food Chem.
PD APR 28
PY 2010
VL 58
IS 8
BP 5174
EP 5180
DI 10.1021/jf100046h
PG 7
WC Agriculture, Multidisciplinary; Chemistry, Applied; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture; Chemistry; Food Science & Technology
GA 584VR
UT WOS:000276782100091
PM 20230058
DA 2025-06-11
ER

PT J
AU Mondal, S
   Barman, P
   Vignesh, P
AF Mondal, Sanjib
   Barman, Prabal
   Vignesh, Pandiarajan
TI Cardiovascular Abnormalities in Juvenile Dermatomyositis: A Scoping
   Review for the Clinical Rheumatologists
SO FRONTIERS IN MEDICINE
LA English
DT Review
DE dermatomyositis; vasculopathy; cardiac dysfunction; acute; long-term;
   screening; imaging
ID IDIOPATHIC INFLAMMATORY MYOPATHIES; CARDIAC INVOLVEMENT; DIASTOLIC
   DYSFUNCTION; METABOLIC SYNDROME; POLYMYOSITIS; HEART; RISK; DIAGNOSIS;
   CHILDREN; MYOSITIS
AB Juvenile dermatomyositis (JDM) is a common form of inflammatory myositis in children. Vasculopathy and endothelial dysfunction play significant roles in the pathogenesis of JDM. Cardiac involvement in JDM is often underestimated, and it may be a potential indicator of poor prognosis. Cardiac dysfunction in JDM can occur both in the acute and chronic stages of the disease. Amongst the acute complications, acute congestive heart failure (CHF), myocarditis, arrhythmia, and complete heart block are common. However, these remain unrecognized due to a lack of overt clinical manifestations. Increased rates of cardiovascular abnormalities have been noted with anti-SRP and anti-Jo 1 auto-antibody positivity. Long-term follow-up studies in JDM have shown an increased prevalence of hypertension, atherosclerosis, coronary artery disease, and metabolic syndrome in adolescence and adulthood. Monitoring of body-mass index, blood pressure, and laboratory evaluation of fasting glucose and lipid profile may help in identifying metabolic syndrome in children with JDM. Steroid-sparing agents, daily exercise, and a healthy diet may reduce such long-term cardiac morbidities. Current use of multimodality imaging such as stress-echocardiography, contrast-enhanced echocardiography, cardiac magnetic resonance imaging, and positron emission tomography has increased the diagnostic yield of subclinical heart disease during acute and chronic stages of JDM. This review elaborates on different aspects of cardiac dysfunction in JDM. It also emphasizes the importance of cardiac screening in long-term follow-up of children with JDM.
C1 [Mondal, Sanjib; Barman, Prabal; Vignesh, Pandiarajan] Post Grad Inst Med Educ & Res, Adv Pediat Ctr, Dept Pediat, Allergy Immunol Unit, Chandigarh, India.
C3 Post Graduate Institute of Medical Education & Research (PGIMER),
   Chandigarh
RP Vignesh, P (corresponding author), Post Grad Inst Med Educ & Res, Adv Pediat Ctr, Dept Pediat, Allergy Immunol Unit, Chandigarh, India.
EM vigimmc@gmail.com
RI Barman, Prabal/LRU-1928-2024
OI Barman, Prabal/0000-0002-0171-668X
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NR 97
TC 4
Z9 6
U1 0
U2 3
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 2296-858X
J9 FRONT MED-LAUSANNE
JI Front. Med.
PD JUN 24
PY 2022
VL 9
AR 827539
DI 10.3389/fmed.2022.827539
PG 10
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 2S6SE
UT WOS:000821919500001
PM 35814777
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Llévenes, P
   Rodrigues-Díez, R
   Cros-Brunsó, L
   Prieto, MI
   Casaní, L
   Balfagón, G
   Blanco-Rivero, J
AF Llevenes, Pablo
   Rodrigues-Diez, Raquel
   Cros-Brunso, Laia
   Isabel Prieto, Ma
   Casani, Laura
   Balfagon, Gloria
   Blanco-Rivero, Javier
TI Beneficial Effect of a Multistrain Synbiotic Prodefen<SUP>®</SUP>
   Plus on the Systemic and Vascular Alterations Associated with
   Metabolic Syndrome in Rats: The Role of the Neuronal Nitric Oxide
   Synthase and Protein Kinase A
SO NUTRIENTS
LA English
DT Article
DE metabolic syndrome; synbiotic; hypertension; superior mesenteric artery;
   perivascular nitrergic innervation; nitric oxide; neuronal nitric oxide
   synthase; protein kinase a
ID DIET-INDUCED OBESITY; GUT MICROBIOTA; MESENTERIC-ARTERY; OXIDATIVE
   STRESS; INSULIN SENSITIVITY; EXPRESSION; PROBIOTICS; ALTERS;
   INNERVATION; IMPROVEMENT
AB A high fat diet (HFD) intake is crucial for the development and progression of metabolic syndrome (MtS). Increasing evidence links gut dysbiosis with the metabolic and vascular alterations associated with MtS. Here we studied the use of a combination of various probiotic strains together with a prebiotic (synbiotic) in a commercially available Prodefen((R)) Plus. MtS was induced by HFD (45%) in male Wistar rats. Half of the MtS animals received Prodefen((R)) Plus for 4 weeks. At 12 weeks, we observed an increase in body weight, together with the presence of insulin resistance, liver steatosis, hypertriglyceridemia and hypertension in MtS rats. Prodefen((R)) Plus supplementation did not affect the body weight gain but ameliorated all the MtS-related symptoms. Moreover, the hypertension induced by HFD is caused by a diminished both nitric oxide (NO) functional role and release probably due to a diminished neuronal nitric oxide synthase (nNOS) activation by protein kinase A (PKA) pathway. Prodefen((R)) Plus supplementation for 4 weeks recovered the NO function and release and the systolic blood pressure was returned to normotensive values as a result. Overall, supplementation with Prodefen((R)) Plus could be considered an interesting non-pharmacological approach in MtS.
C1 [Llevenes, Pablo; Cros-Brunso, Laia; Balfagon, Gloria; Blanco-Rivero, Javier] Univ Autonoma Madrid, Sch Med, Dept Physiol, Calle Arzobispo Morcillo 4, Madrid 28029, Spain.
   [Rodrigues-Diez, Raquel] Univ Autonoma Madrid, Sch Med, Dept Pharmacol & Therapeut, Calle Arzobispo Morcillo 4, Madrid 28029, Spain.
   [Rodrigues-Diez, Raquel; Balfagon, Gloria; Blanco-Rivero, Javier] Ctr Biomed Res Network CIBER Cardiovasc Dis, Calle Melchor Fernandez Almagro 3, Madrid 28029, Spain.
   [Rodrigues-Diez, Raquel; Isabel Prieto, Ma; Balfagon, Gloria; Blanco-Rivero, Javier] Univ Hosp la Paz IdIPaz, Res Inst, Calle Pedro Rico 6, Madrid 28029, Spain.
   [Isabel Prieto, Ma] Hosp Univ la Paz, Dept Gen & Digest Surg, Paseo Castellana 261, Madrid 28046, Spain.
   [Casani, Laura] Res Inst Santa Creu, Carrer St Quinti 77-79, Barcelona 08041, Spain.
   [Casani, Laura] St Pau Hosp, Carrer St Quinti 77-79, Barcelona 08041, Spain.
C3 Autonomous University of Madrid; Autonomous University of Madrid;
   Hospital Universitario La Paz; Hospital of Santa Creu i Sant Pau
RP Blanco-Rivero, J (corresponding author), Univ Autonoma Madrid, Sch Med, Dept Physiol, Calle Arzobispo Morcillo 4, Madrid 28029, Spain.; Blanco-Rivero, J (corresponding author), Ctr Biomed Res Network CIBER Cardiovasc Dis, Calle Melchor Fernandez Almagro 3, Madrid 28029, Spain.; Blanco-Rivero, J (corresponding author), Univ Hosp la Paz IdIPaz, Res Inst, Calle Pedro Rico 6, Madrid 28029, Spain.
EM pablollevenes@gmail.com; raquel.rodrigues@uam.es; croslaia@gmail.com;
   iprieto@intermic.com; lcasani@santpau.cat; gloria.balfagon@uam.es;
   javier.blanco@uam.es
RI Rivero, Javier/ABE-8749-2020; Díez, Raquel/ABE-9703-2020; Prieto,
   Isabel/U-1061-2017; Casani, Laura/S-2115-2019; Blanco Rivero,
   Javier/J-6118-2014
OI PRIETO-NIETO, MARIA ISABEL/0000-0001-7619-0531; Cros-Brunso,
   Laia/0000-0002-7554-1018; Blanco Rivero, Javier/0000-0001-7232-2314;
   Casani, Laura/0000-0002-0139-4588; Rodrigues Diez,
   Raquel/0000-0002-6348-1505; Llevenes, Pablo/0000-0003-1925-7204
FU Italfarmaco, S.A [L.O.U. 83, 0138/2018]; CiberCV [CB16/11/00286];
   European Regional Development Grant (FEDER) (Comunidad de Madrid)
   [B2017/BMD-3676]; R + D projects for young researchers, Universidad
   Autonoma de Madrid (Comunidad de Madrid) [SI1-PJI-2019-00321]; Juan de
   la Cierva Program [IJCI-2017-31399]
FX This research was funded by Italfarmaco, S.A (L.O.U. 83; 0138/2018),
   CiberCV (Grant number: CB16/11/00286), the European Regional Development
   Grant (FEDER) (Comunidad de Madrid, Grant number B2017/BMD-3676), and R
   + D projects for young researchers, Universidad Autonoma de Madrid
   (Comunidad de Madrid (SI1-PJI-2019-00321). R.R.-D. received a fellowship
   from Juan de la Cierva Program (IJCI-2017-31399).
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NR 71
TC 12
Z9 14
U1 1
U2 8
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JAN
PY 2020
VL 12
IS 1
AR 117
DI 10.3390/nu12010117
PG 18
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA KQ3KN
UT WOS:000516825500117
PM 31906276
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Rocha, NG
   Templeton, DL
   Greiner, JJ
   Stauffer, BL
   DeSouza, CA
AF Rocha, Natalia G.
   Templeton, Danielle L.
   Greiner, Jared J.
   Stauffer, Brian L.
   DeSouza, Christopher A.
TI Metabolic syndrome and endothelin-1 mediated vasoconstrictor tone in
   overweight/obese adults
SO METABOLISM-CLINICAL AND EXPERIMENTAL
LA English
DT Article
DE Metabolic syndrome; Endothelin-1; Blood flow
ID CARDIOVASCULAR-DISEASE; DEPENDENT VASODILATION; OXIDATIVE STRESS;
   VASCULAR-TONE; HEART; DYSFUNCTION; DEFINITION; ANTAGONISM; RESISTANCE;
   RECEPTORS
AB Objective. To determine whether endothelin (ET)-1 vasoconstrictor tone is greater overweight and obese adults with the metabolic syndrome (MetS).
   Materials/Methods. Forty overweight/obese middle-aged and older adults (age: 43-71 years; BMI: 25.1-36.9 kg/m(2)) were studied: 20 without MetS (13 M/7 F) and 20 with MetS (13 M/7 F). MetS was established according to NCEP ATP III guidelines. Forearm blood flow (FBF; plethysmography) responses to intra-arterial infusion of selective ETA receptor blockade (BQ-123; 100 nmol/min; for 60 min) and non-selective ETA/B receptor blockade (BQ-123 + BQ-788 [50 nmol/min for 60 min]) were determined.
   Results. In response to the selective ETA antagonism, there was a significant increase in forearm blood flow from baseline in both groups. However, the increase in forearm blood flow was significantly higher (P = 0.03; similar to 45%) in the overweight/obese group with MetS than the group without MetS. In contrast, there were no significant group differences in FBF responses to nonselective ETA/B receptor blockade. Peak vasodilator responses to nonselective ETA/B blockade were similar to 0% higher than baseline blood flow in the overweight/obese groups without and with MetS.
   Conclusion. MetS is associated with higher ET-1 vasoconstrictor tone in overweight/obese adults. The enhanced ET-1 vasoconstrictor activity with MetS is mediated by the ETA receptor subtype. (c) 2014 Elsevier Inc. All rights reserved.
C1 [Rocha, Natalia G.; Templeton, Danielle L.; Greiner, Jared J.; Stauffer, Brian L.; DeSouza, Christopher A.] Univ Colorado, Dept Integrat Physiol, Integrat Vasc Biol Lab, Boulder, CO 80309 USA.
   [Stauffer, Brian L.; DeSouza, Christopher A.] Univ Colorado, Dept Med, Aurora, CO 80045 USA.
   [Stauffer, Brian L.; DeSouza, Christopher A.] Hlth Sci Ctr, Aurora, CO 80045 USA.
   [Stauffer, Brian L.] Denver Hlth Med Ctr, Denver, CO 80204 USA.
   [Rocha, Natalia G.] Univ Fed Fluminense, Dept Physiol & Pharmacol, BR-24210130 Niteroi, RJ, Brazil.
C3 University of Colorado System; University of Colorado Boulder;
   University of Colorado System; University of Colorado Anschutz Medical
   Campus; Denver Health Medical Center; Universidade Federal Fluminense
RP DeSouza, CA (corresponding author), Univ Colorado, Dept Integrat Physiol, Integrat Vasc Biol Lab, 354 UCB, Boulder, CO 80309 USA.
EM desouzac@colorado.edu
RI Stauffer, Brian/W-8251-2019; Rocha, Natalia Galito/AAN-7903-2020
OI Stauffer, Brian/0000-0003-3418-7750; Rocha, Natalia
   Galito/0000-0002-1990-9834
FU National Institutes of Health [HL077450, HL076434, UL1 TR000154];
   American Heart Association award [0840167N]; American Heart Association
   (AHA) [0840167N] Funding Source: American Heart Association (AHA)
FX This study was supported by National Institutes of Health awards
   HL077450, HL076434, and UL1 TR000154 and American Heart Association
   award 0840167N.
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NR 39
TC 17
Z9 18
U1 0
U2 5
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0026-0495
EI 1532-8600
J9 METABOLISM
JI Metab.-Clin. Exp.
PD JUL
PY 2014
VL 63
IS 7
BP 951
EP 956
DI 10.1016/j.metabol.2014.04.007
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA AJ5ID
UT WOS:000337715000010
PM 24856242
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Martín-Cordero, L
   García, JJ
   Ortega, E
AF Martin-Cordero, Leticia
   Garcia, Juan J.
   Ortega, Eduardo
TI Noradrenaline-mediated Inhibition of Inflammatory Cytokines is Altered
   in Macrophages from Obese Zucker Rats: Effect of Habitual Exercise
SO ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS
LA English
DT Article
DE Inflammation; macrophages; metabolic syndrome; noradrenaline; obesity;
   physical activity
ID NECROSIS-FACTOR-ALPHA; METABOLIC SYNDROME; IN-VIVO; STRESS; RELEASE;
   MODULATION; EXPRESSION; IL-6
AB The obese Zucker rat (fa/fa) (ObZ) is a good animal model for Metabolic Syndrome (MS)-associated neuroendocrine and inflammatory disorders. The aim of the present investigation was to evaluate the effect of noradrenaline (NA) on the release of IL-1 beta, IL-6 and TNF alpha by macrophages from ObZ, as well as the effect of habitual exercise (running, 5days/week for 35 min at 35cm/s for 14week); all of them using lean Zucker rats (Fa/fa) (LZ) as reference values. Cytokines were determined by ELISA in the supernatants of macrophages cultured for 24h (37 degrees C, 5% CO2 and 100% RH) in presence or absence of 10-5M NA. Both the spontaneous and NA-induced release of IL-1 beta and IL-6 were higher in sedentary obese (ObSZ) rats than in healthy LZ rats (a significant lower spontaneous production of TNF alpha was also found in the ObSZ rats). While the NA-induced release of IL-1 beta was higher in the exercised obese (ObTZ) rats, the NA-induced production of IL-6 was lower compared with ObSZ rats. In addition, NA has an inhibitory role on the release of IL-1 beta and TNF alpha (with respect to the spontaneous release) in both lean and obese (sedentary and exercised) rats. However, NA inhibits the IL-6 production by macrophages from lean and exercised obese animals, but promotes IL-6 release in the sedentary obese rats.
C1 [Martin-Cordero, Leticia; Garcia, Juan J.; Ortega, Eduardo] Univ Extremadura, Fac Sci, Dept Physiol, Immunophysiol Res Grp, Badajoz, Spain.
C3 Universidad de Extremadura
RP Ortega, E (corresponding author), Univ Extremadura, Fac Sci, Dept Physiol, Immunophysiol Res Grp, Badajoz, Spain.
EM orincon@unex.es
RI Martin-Cordero, Leticia/H-9711-2015; Ortega, Eduardo/H-9891-2016;
   Garcia, Juan/C-7383-2013
OI Martin-Cordero, Leticia/0000-0002-3651-2265; Ortega,
   Eduardo/0000-0002-7007-7615; Garcia, Juan/0000-0002-8222-4213
FU Ministerio de Ciencia e Innovacion-Fondo Europeo de Desarrollo Regional
   [DEP2006 56187]; Junta de Extremadura-FEDER, Spain [GR10020]
FX This work was supported by Ministerio de Ciencia e Innovacion-Fondo
   Europeo de Desarrollo Regional (DEP2006 56187) and Junta de
   Extremadura-FEDER (GR10020), Spain.
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NR 35
TC 12
Z9 12
U1 0
U2 3
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1871-5303
EI 2212-3873
J9 ENDOCR METAB IMMUNE
JI Endocr. Metab. Immune Disord.-Drug Targets
PD SEP
PY 2013
VL 13
IS 3
BP 234
EP 239
PG 6
WC Endocrinology & Metabolism; Immunology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Immunology; Pharmacology & Pharmacy
GA 242HD
UT WOS:000326228600002
PM 23808809
DA 2025-06-11
ER

PT J
AU Boersma, GJ
   Benthem, L
   van Dijk, G
   Scheurink, AJW
AF Boersma, Gretha J.
   Benthem, Lambertus
   van Dijk, Gertjan
   Scheurink, Anton J. W.
TI Individual variation in the (patho)physiology of energy balance
SO PHYSIOLOGY & BEHAVIOR
LA English
DT Article
DE Coping style; Insulin; Hypertension; Physical activity
ID LOW-AVOIDANCE RATS; ROMAN HIGH-AVOIDANCE; CORTICOTROPIN-RELEASING
   FACTOR; PLASMA-CATECHOLAMINE; CORTICOSTERONE LEVELS;
   CEREBROSPINAL-FLUID; INSULIN-RESISTANCE; METABOLIC SYNDROME; COPING
   STRATEGIES; STRESS RESPONSES
AB There are large individual differences in the susceptibility for metabolic disorders such as obesity, the metabolic syndrome and type 2 diabetes. Unfortunately, most animal studies in this field ignore the importance of individual variation which limits the face validity of these studies for translation to the human situation. We have performed a series of studies that were particularly focused on the individual differences in the (patho)physiology of energy balance. The studies were performed with passive and proactive individuals of two different rat strains: the Roman High and Low Avoidance rats and the Wild type Groningen rat. The data reveal that passive and proactive individuals differ significantly on several parameters, i.e. body composition, Hypothalamic-Pituitary-Adrenal (HPA) axis activity, plasma levels of insulin and leptin, intestinal transit time, systolic blood pressure and meal patterns. We also found that the selection line of the Roman Low Avoidance rat may be considered as a non-obese animal model for the metabolic syndrome, since these rats display, under sedentary conditions, many of the related symptoms such as hypertension, visceral adiposity and insulin resistance during an intravenous glucose tolerance test. These symptoms disappeared when the animals were allowed to exercise voluntarily in a running wheel. We conclude that experiments with passive and proactive individuals are highly relevant for studying the (patho)physiology and behavior of energy balance and the related metabolic disorders. (C) 2011 Elsevier Inc. All rights reserved.
C1 [Boersma, Gretha J.; van Dijk, Gertjan; Scheurink, Anton J. W.] Univ Groningen, Dept Neuroendocrinol, NL-9750 AA Haren, Netherlands.
   [Benthem, Lambertus] AstraZeneca R&D, Biosci Diabet Obes, Molndal, Sweden.
C3 University of Groningen; AstraZeneca
RP Boersma, GJ (corresponding author), Univ Groningen, Dept Neuroendocrinol, POB 14, NL-9750 AA Haren, Netherlands.
EM g.j.boersma@rug.nl
OI van Dijk, Gertjan/0000-0002-6565-4019
FU AstraZeneca
FX These studies were supported by an unrestricted research grant by
   AstraZeneca.
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NR 84
TC 14
Z9 14
U1 0
U2 10
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0031-9384
J9 PHYSIOL BEHAV
JI Physiol. Behav.
PD APR 18
PY 2011
VL 103
IS 1
SI SI
BP 89
EP 97
DI 10.1016/j.physbeh.2010.12.026
PG 9
WC Psychology, Biological; Behavioral Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Behavioral Sciences
GA 749VR
UT WOS:000289499800015
PM 21237186
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Liu, L
   Li, X
   Wu, MY
   Yu, M
   Wang, LM
   Hu, LQ
   Li, YP
   Song, LL
   Wang, YJ
   Mei, SR
AF Liu, Ling
   Li, Xiang
   Wu, Mingyang
   Yu, Meng
   Wang, Limei
   Hu, Liqin
   Li, Yaping
   Song, Lulu
   Wang, Youjie
   Mei, Surong
TI Individual and joint effects of metal exposure on metabolic syndrome
   among Chinese adults
SO CHEMOSPHERE
LA English
DT Article
DE Metals; Metabolic syndrome; Joint effects; Elastic net model; Chinese
   adults
ID OXIDATIVE STRESS; VARIABLE SELECTION; PHYSICAL-ACTIVITY;
   NATIONAL-HEALTH; SELENIUM LEVELS; TRACE-ELEMENTS; SERUM ZINC; US ADULTS;
   ASSOCIATION; RISK
AB Growing evidence suggests that metal exposure contributes to metabolic syndrome (MetS), but little is known about the effects of combined exposure to metal mixtures. This cross-sectional study included 3748 adults who were recruited from the Medical Physical Examination Center of Tongji Hospital, Wuhan, China. The levels of 21 metal(loid)s in urine were measured by inductively coupled plasma mass spectrometry. MetS was diagnosed according to National Cholesterol Education Program's Adult Treatment Panel III recommendations. Multivariate logistic regression model was uesd to explore the effects of single-metal and multi-metal exposures. The elastic net (ENET) regularization with an environmental risk score (ERS) was performed to estimate the joint effects of exposure to metal mixtures. A total of 636 participants (17%) were diagnosed with MetS. In single metal models, MetS was positively associated with zinc (Zn) and negatively associated with nickel (Ni). In multiple metal models, the associations remained significant after adjusting for the other metals. In the joint association analysis, the ENET models selected Zn as the strongest predictor of MetS. Compared to the lowest quartile, the highest quartile of ERS was associated with an elevated risk of MetS (OR = 3.72; 95% CI: 2.77, 5.91;P-trend < 0.001). Overall, we identified that the combined effect of multiple metals was related to an increased MetS risk, with Zn being the major contributor. These findings need further validation in prospective studies.
C1 [Liu, Ling; Li, Xiang; Yu, Meng; Wang, Limei; Hu, Liqin; Li, Yaping; Wang, Youjie; Mei, Surong] Huazhong Univ Sci & Technol, State Key Lab Environm Hlth Incubat,Tongji Med Co, Key Lab Environm & Hlth Wuhan,Minist Environm Pro, Key Lab Environm & Hlth,Minist Educ,Sch Publ Hlth, 13 Hongkong Rd, Wuhan 430030, Hubei, Peoples R China.
   [Wu, Mingyang; Song, Lulu; Wang, Youjie] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Dept Maternal & Child Hlth, Wuhan, Hubei, Peoples R China.
C3 Ministry of Education - China; Huazhong University of Science &
   Technology; Huazhong University of Science & Technology
RP Wang, YJ (corresponding author), Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Dept Maternal & Child Hlth, Wuhan, Hubei, Peoples R China.; Mei, SR (corresponding author), Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, 13 Hangkong Rd, Wuhan 430030, Hubei, Peoples R China.
EM wangyoujie@mails.tjmu.edu.cn; surongmei@hust.edu.cn
RI Li, Xiang/IYT-7014-2023; Li, zhuangzhuang/JAD-1371-2023; Wu,
   Mingyang/JRX-1464-2023; Song, Lulu/X-4115-2019
OI Song, Lulu/0000-0002-9105-2580; Wu, mingyang/0000-0003-3001-1897
FU National Key Research and Development Program of China [2019YFC1605100]
FX We appreciate the hospital and all participants in this study. This work
   was supported by the National Key Research and Development Program of
   China (2019YFC1605100) .
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NR 116
TC 19
Z9 20
U1 0
U2 39
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0045-6535
EI 1879-1298
J9 CHEMOSPHERE
JI Chemosphere
PD JAN
PY 2022
VL 287
AR 132295
DI 10.1016/j.chemosphere.2021.132295
EA SEP 2021
PN 3
PG 10
WC Environmental Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology
GA WD5GN
UT WOS:000704969000004
PM 34563779
DA 2025-06-11
ER

PT J
AU Bordet, S
   Luaces, JP
   Herrera, MI
   Gonzalez, LM
   Kobiec, T
   Perez-Lloret, S
   Otero-Losada, M
   Capani, F
AF Bordet, Sofia
   Luaces, Juan Pablo
   Herrera, Maria Ines
   Gonzalez, Liliana Mirta
   Kobiec, Tamara
   Perez-Lloret, Santiago
   Otero-Losada, Matilde
   Capani, Francisco
TI Neuroprotection from protein misfolding in cerebral hypoperfusion
   concurrent with metabolic syndrome. A translational perspective
SO FRONTIERS IN NEUROSCIENCE
LA English
DT Review
DE metabolic syndrome; type 2 diabetes; chronic cerebral hypoperfusion;
   protein misfolding; neurodegeneration; animal models
ID HIGH-FAT DIET; VASCULAR COGNITIVE IMPAIRMENT; DIABETES-MELLITUS;
   WOLFRAM-SYNDROME; ANIMAL-MODELS; ER STRESS; RODENT MODELS; MOUSE MODEL;
   WFS1 GENE; OBESITY
AB Based on clinical and experimental evidence, metabolic syndrome (MetS) and type 2 diabetes (T2D) are considered risk factors for chronic cerebral hypoperfusion (CCH) and neurodegeneration. Scientific evidence suggests that protein misfolding is a potential mechanism that explains how CCH can lead to either Alzheimer's disease (AD) or vascular cognitive impairment and dementia (VCID). Over the last decade, there has been a significant increase in the number of experimental studies regarding this issue. Using several animal paradigms and different markers of CCH, scientists have discussed the extent to which MetSor T2D causes a decrease in cerebral blood flow (CBF). In addition, different models of CCH have explored how long-term reductions in oxygen and energy supply can trigger AD or VCID via protein misfolding and aggregation. Research that combines two or three animal models could broaden knowledge of the links between these pathological conditions. Recent experimental studies suggest novel neuroprotective properties of protein-remodeling factors. In this review, we present a summarized updated revision of preclinical findings, discussing clinical implications and proposing new experimental approaches from a translational perspective. We are confident that research studies, both clinical and experimental, may find new diagnostic and therapeutic tools to prevent neurodegeneration associated with MetS, diabetes, and any other chronic non-communicable disease (NCD) associated with diet and lifestyle risk factors.
C1 [Bordet, Sofia; Luaces, Juan Pablo; Herrera, Maria Ines; Gonzalez, Liliana Mirta; Kobiec, Tamara; Otero-Losada, Matilde; Capani, Francisco] Univ Abierta Interamer, Ctr Altos Estudios Ciencias Humanas & Salud, Consejo Nacl Invest Cient & Tecn, CAECIHS,UAI CONICET, Buenos Aires, Argentina.
   [Bordet, Sofia; Herrera, Maria Ines; Kobiec, Tamara] Pontificia Univ Catolica Argentina UCA, Fac Psicol & Psicopedag, Ctr Invest Psicol & Psicopedag CIPP, Buenos Aires, Argentina.
   [Perez-Lloret, Santiago] Univ Buenos Aires UBA, Fac Med, Dept Fisiol, Buenos Aires, Argentina.
   [Perez-Lloret, Santiago] Pontificia Univ Catolica Argentina, Consejo Nacl Invest Cient & Tecn, Observ Salud Publ, Buenos Aires, Argentina.
   [Capani, Francisco] Univ Autonoma Chile, Fac Ciencias Salud, Inst Ciencias Biomed, Santiago, Chile.
C3 Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET);
   Pontificia Universidad Catolica Argentina; University of Buenos Aires;
   Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET);
   Pontificia Universidad Catolica Argentina; Universidad Autonoma de Chile
RP Capani, F (corresponding author), Univ Abierta Interamer, Ctr Altos Estudios Ciencias Humanas & Salud, Consejo Nacl Invest Cient & Tecn, CAECIHS,UAI CONICET, Buenos Aires, Argentina.; Capani, F (corresponding author), Univ Autonoma Chile, Fac Ciencias Salud, Inst Ciencias Biomed, Santiago, Chile.
EM franciscocapani@hotmail.com
RI capani, Francisco/D-9781-2016; Luaces, Juan/NDT-5206-2025
FU COFECyT [PF103 2022-262,025, PICT-2020-SERIEA-01926]
FX This work was supported by grants to FC from COFECyT PF103 2022-262,025,
   PS1 UAI 2023-2025, UK 2023-2025, PICT-2020-SERIEA-01926.
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NR 85
TC 1
Z9 1
U1 1
U2 5
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1662-453X
J9 FRONT NEUROSCI-SWITZ
JI Front. Neurosci.
PD AUG 15
PY 2023
VL 17
AR 1215041
DI 10.3389/fnins.2023.1215041
PG 7
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA Q7DD4
UT WOS:001059082400001
PM 37650104
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Caiati, C
   Stanca, A
   Lepera, ME
AF Caiati, Carlo
   Stanca, Alessandro
   Lepera, Mario Erminio
TI Free Radicals and Obesity-Related Chronic Inflammation Contrasted by
   Antioxidants: A New Perspective in Coronary Artery Disease
SO METABOLITES
LA English
DT Review
DE metabolic syndrome; antioxidants; free radicals; coronary
   atherosclerosis; oxidized LDL; toxicity
ID NF-KAPPA-B; ALL-CAUSE MORTALITY; OXIDATIVE STRESS;
   CARDIOVASCULAR-DISEASE; ENDOTHELIAL DYSFUNCTION; CIGARETTE-SMOKING;
   DIETARY ANTIOXIDANTS; INSULIN-RESISTANCE; METABOLIC SYNDROME; AMALGAM
   FILLINGS
AB We are surrounded by factors called free radicals (FR), which attach to the molecules our body is made of, first among them the endothelium. Even though FR are to a certain extent a normal factor, nowadays we face an escalating increase in these biologically aggressive molecules. The escalating formation of FR is linked to the increased usage of man-made chemicals for personal care (toothpaste, shampoo, bubble bath, etc.), domestic laundry and dish-washer detergents, and also an ever wider usage of drugs (both prescription and over the counter), especially if they are to be used long-term (years). In addition, tobacco smoking, processed foods, pesticides, various chronic infectious microbes, nutritional deficiencies, lack of sun exposure, and, finally, with a markedly increasing impact, electromagnetic pollution (a terribly destructive factor), can increase the risk of cancer, as well as endothelial dysfunction, owing to the increased production of FR that they cause. All these factors create endothelial damage, but the organism may be able to repair such damage thanks to the intervention of the immune system supported by antioxidants. However, one other factor can perpetuate the state of inflammation, namely obesity and metabolic syndrome with associated hyperinsulinemia. In this review, the role of FR, with a special emphasis on their origin, and of antioxidants, is explored from the perspective of their role in causing atherosclerosis, in particular at the coronary level.
C1 [Caiati, Carlo; Stanca, Alessandro; Lepera, Mario Erminio] Univ Bari Aldo Moro, Dept Interdisciplinary Med, Unit Cardiovasc Dis, I-70124 Bari, Italy.
C3 Universita degli Studi di Bari Aldo Moro
RP Caiati, C (corresponding author), Univ Bari Aldo Moro, Dept Interdisciplinary Med, Unit Cardiovasc Dis, I-70124 Bari, Italy.
EM carlo.caiati@uniba.it; alessandrostanca@gmail.com;
   marioerminio.lepera@uniba.it
RI caiati, carlo/AAG-3971-2021
OI Caiati, Carlo/0000-0002-7447-575X; Stanca,
   Alessandro/0009-0002-0512-7572
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NR 204
TC 14
Z9 14
U1 0
U2 3
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2218-1989
J9 METABOLITES
JI Metabolites
PD JUN
PY 2023
VL 13
IS 6
AR 712
DI 10.3390/metabo13060712
PG 23
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA K2MF1
UT WOS:001014825000001
PM 37367870
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Wu, YQ
   Zhang, Y
   Jiao, JJ
AF Wu, Yuqi
   Zhang, Yu
   Jiao, Jingjing
TI The relationship between n-3 polyunsaturated fatty acids and telomere: A
   review on proposed nutritional treatment against metabolic syndrome and
   potential signaling pathways
SO CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
LA English
DT Review
DE n-3 polyunsaturated acids; metabolic syndrome; telomere; signaling
   pathway
ID OXIDATIVE STRESS; FISH-OIL; CARDIOVASCULAR-DISEASE; DOCOSAHEXAENOIC
   ACID; DNA-DAMAGE; INSULIN SENSITIVITY; ADIPOSE-TISSUE; UP-REGULATION;
   DOUBLE-BLIND; LENGTH
AB Metabolic syndrome (MetS), a cluster of metabolic abnormalities composed of central obesity, elevated blood pressure, glucose disturbances, hypercholesterolemia and dyslipidaemia, has increasingly become a public health problem in the 21st century worldwide. The dysfunction of telomeres, the repetitive DNA with highly conserved sequences (5 '-TTAGGG-3 '), is remarkably correlated with organismal aging, even suggesting a causal relationship with metabolic disorders. The health benefits of n-3 polyunsaturated fatty acids (PUFAs) in multiple disorders are associated with telomere length in evidence, which have recently drawn wide attention. However, functional targets and pathways for the associations of n-3 PUFAs and telomere with MetS remain scare. Few studies have summarized the role of n-3 PUFAs in DNA damage repair pathways, anti-inflammatory pathways, and redox balance, linking with telomere biology, and other potential telomere-related signaling pathways. This review aims to (i) elucidate how n-3 PUFAs ameliorate telomere attrition in the context of anti-oxidation and anti-inflammation; (ii) unravel the role of n-3 PUFAs in modulating telomere-related neuron dysfunction and regulating the neuro-endocrine-immunological network in MetS; (iii) epidemiologically implicate the associations of metabolic disorders and n-3 PUFAs with telomere length; and (iv) suggest promising biochemical approaches and advancing methodologies to overcome the inter-variation problem helpful for future research.
C1 [Wu, Yuqi; Zhang, Yu] Zhejiang Univ, Coll Biosyst Engn & Food Sci, Fuli Inst Food Sci,Zhejiang Key Lab Agrofood Proc, Natl Engn Lab Intelligent Food Technol & Equipmen, Hangzhou, Zhejiang, Peoples R China.
   [Jiao, Jingjing] Zhejiang Univ, Affiliated Hosp 2, Sch Publ Hlth, Dept Nutr,Dept Clin Nutr,Sch Med, Hangzhou, Zhejiang, Peoples R China.
C3 Zhejiang University; Zhejiang University
RP Jiao, JJ (corresponding author), Zhejiang Univ, Affiliated Hosp 2, Sch Publ Hlth, Dept Nutr,Dept Clin Nutr,Sch Med, Hangzhou, Zhejiang, Peoples R China.
EM jingjingjiao@zju.edu.cn
RI Wu, Yu/AAX-8654-2020
OI Zhang, Yu/0000-0003-1025-906X; Jiao, Jingjing/0000-0003-4167-1567
FU National Natural Science Foundation of Zhejiang Province [LR18C200001]
FX National Natural Science Foundation of Zhejiang Province LR18C200001.
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NR 168
TC 1
Z9 1
U1 2
U2 15
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1040-8398
EI 1549-7852
J9 CRIT REV FOOD SCI
JI Crit. Rev. Food Sci. Nutr.
PD MAY 29
PY 2024
VL 64
IS 14
BP 4457
EP 4476
DI 10.1080/10408398.2022.2142196
EA OCT 2022
PG 20
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA QO3A7
UT WOS:000878903000001
PM 36330807
DA 2025-06-11
ER

PT J
AU Song, GH
   Li, M
   Sang, H
   Zhang, LY
   Li, XH
   Yao, ST
   Yu, Y
   Zong, CL
   Xue, YH
   Qin, SC
AF Song, Guohua
   Li, Min
   Sang, Hui
   Zhang, Liying
   Li, Xiuhong
   Yao, Shutong
   Yu, Yang
   Zong, Chuanlong
   Xue, Yazhuo
   Qin, Shucun
TI Hydrogen-rich water decreases serum LDL-cholesterol levels and improves
   HDL function in patients with potential metabolic syndrome
SO JOURNAL OF LIPID RESEARCH
LA English
DT Article
DE apolipoprotein B; antioxidative property; low density lipoprotein; high
   density lipoprotein
ID LOW-DENSITY-LIPOPROTEIN; TRANSFER PROTEIN; MESSENGER-RNA; INFLAMMATION;
   DYSLIPIDEMIA; ASSOCIATION; RECEPTOR; GENE
AB We have found that hydrogen (dihydrogen; H-2) has beneficial lipid-lowering effects in high-fat diet-fed Syrian golden hamsters. The objective of this study was to characterize the effects of H-2-rich water (0.9-1.0 l/day) on the content, composition, and biological activities of serum lipoproteins on 20 patients with potential metabolic syndrome. Serum analysis showed that consumption of H-2-rich water for 10 weeks resulted in decreased serum total-cholesterol (TC) and LDL-cholesterol (LDL-C) levels. Western blot analysis revealed a marked decrease of apolipoprotein (apo)B100 and apoE in serum. In addition, we found H-2 significantly improved HDL functionality assessed in four independent ways, namely, i) protection against LDL oxidation, ii) inhibition of tumor necrosis factor (TNF)-alpha-induced monocyte adhesion to endothelial cells, iii) stimulation of cholesterol efflux from macrophage foam cells, and iv) protection of endothelial cells from TNF-alpha-induced apoptosis. Further, we found consumption of H-2-rich water resulted in an increase in antioxidant enzyme superoxide dismutase and a decrease in thiobarbituric acid-reactive substances in whole serum and LDL. In conclusion, supplementation with H-2-rich water seems to decrease serum LDL-C and apoB levels, improve dyslipidemia-injured HDL functions, and reduce oxidative stress, and it may have a beneficial role in prevention of potential metabolic syndrome.
C1 [Song, Guohua; Yu, Yang; Zong, Chuanlong; Qin, Shucun] Shandong Univ, Key Lab Atherosclerosis, Jinan, Shandong, Peoples R China.
   [Song, Guohua; Yu, Yang; Zong, Chuanlong; Qin, Shucun] Taishan Med Univ, Inst Atherosclerosis, Tai An, Shandong, Peoples R China.
   [Li, Min; Zhang, Liying; Xue, Yazhuo] Taishan Med Univ, Inst Nursing, Tai An, Shandong, Peoples R China.
   [Sang, Hui; Yao, Shutong] Taishan Med Univ, Inst Basic Med, Tai An, Shandong, Peoples R China.
   [Li, Xiuhong] Taishan Mental Dis Hosp, Tai An, Shandong, Peoples R China.
C3 Shandong University; Taishan University; Shandong First Medical
   University & Shandong Academy of Medical Sciences; Shandong First
   Medical University & Shandong Academy of Medical Sciences; Taishan
   University; Taishan University; Shandong First Medical University &
   Shandong Academy of Medical Sciences
RP Xue, YH (corresponding author), Taishan Med Univ, Inst Nursing, Tai An, Shandong, Peoples R China.
EM yzxue@tsmc.edu.cn; shucunqin@hotmail.com
RI Li, Xiuhong/KHT-5321-2024
FU Taishan Scholars Foundation of Shandong Province [zd056, zd057]; special
   research funding of Taishan Medical University; National Natural Science
   Foundation of China [81200216]; Promotive Research Fund for Excellent
   Young and Middle-aged Scientists of Shandong Province [BS2012YY034]
FX This work was supported by the Taishan Scholars Foundation of Shandong
   Province (zd056, zd057); special research funding of Taishan Medical
   University (2008); National Natural Science Foundation of China
   (81200216), and Promotive Research Fund for Excellent Young and
   Middle-aged Scientists of Shandong Province (BS2012YY034).
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NR 30
TC 105
Z9 117
U1 2
U2 40
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0022-2275
EI 1539-7262
J9 J LIPID RES
JI J. Lipid Res.
PD JUL
PY 2013
VL 54
IS 7
BP 1884
EP 1893
DI 10.1194/jlr.M036640
PG 10
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 162AA
UT WOS:000320235200016
PM 23610159
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Teragawa, H
   Morita, K
   Shishido, H
   Otsuka, N
   Hirokawa, Y
   Chayama, K
   Tamaki, N
   Kihara, Y
AF Teragawa, Hiroki
   Morita, Koichi
   Shishido, Hiroki
   Otsuka, Nobuaki
   Hirokawa, Yutaka
   Chayama, Kazuaki
   Tamaki, Nagara
   Kihara, Yasuki
TI Impaired myocardial blood flow reserve in subjects with metabolic
   syndrome analyzed using positron emission tomography and N-13 labeled
   ammonia
SO EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
LA English
DT Article
DE Metabolic syndrome; Abnormal coronary microvascular response; Insulin
   resistance
ID NITRIC-OXIDE SYNTHASE; ENDOTHELIAL DYSFUNCTION; CARDIOVASCULAR-DISEASE;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; PROGNOSTIC VALUE; CORONARY; RISK;
   HYPERTENSION; MORTALITY
AB Coronary vasomotor response might be impaired in metabolic syndrome (MS); however, the precise abnormality has not been elucidated. The aim of this study was to assess coronary-vasomotor response in MS subjects using N-13 labeled ammonia and positron emission tomography.
   Myocardial blood flow (MBF) was measured at rest and during adenosine infusion in MS subjects (n = 13, MS group) with no definite evidence of heart disease and in subjects without MS (n = 14, non-MS group). Coronary vascular resistance (CVR) was calculated by dividing the mean aortic blood pressure by MBF. Myocardial blood flow reserve (MFR) was calculated as the ratio of the MBF during adenosine infusion to that during rest. Blood chemical parameters were measured to evaluate their relationship with MFR. During adenosine infusion, MBF was lower (p = 0.0085) and CVR higher (p = 0.0128) in the MS group than in the non-MS group and MFR was significantly lower in the MS group than in the non-MS group (2.13 +/- 0.99 vs. 3.38 +/- 0.95, p = 0.0027). Multivariate analysis demonstrated that the homeostasis model assessment-insulin resistance (p < 0.05) and the presence of hypertension (p < 0.05) were independent determinants of MFR.
   The results indicate that MFR was impaired in MS subjects, suggesting that an abnormal coronary microvascular response occurred in these subjects. This abnormality may have been partially due to insulin resistance and hypertension.
C1 [Teragawa, Hiroki; Kihara, Yasuki] Hiroshima Univ, Grad Sch Biomed Sci, Dept Cardiovasc Med, Minami Ku, Hiroshima 7348551, Japan.
   [Morita, Koichi; Tamaki, Nagara] Hokkaido Univ, Grad Sch Med, Dept Nucl Med, Sapporo, Hokkaido, Japan.
   [Shishido, Hiroki; Otsuka, Nobuaki; Hirokawa, Yutaka] Hiroshima Heiwa Clin, Hiroshima, Japan.
   [Chayama, Kazuaki] Hiroshima Univ, Grad Sch Biomed Sci, Dept Mol Sci & Med, Hiroshima 7348551, Japan.
C3 Hiroshima University; Hokkaido University; Hiroshima University
RP Teragawa, H (corresponding author), Hiroshima Univ, Grad Sch Biomed Sci, Dept Cardiovasc Med, Minami Ku, 1-2-3 Kasumi, Hiroshima 7348551, Japan.
EM hteraga@hiroshima-u.ac.jp
RI Teragawa, Hiroki/AAJ-5116-2020; Chayama, Kazuaki/B-2493-2016
OI Chayama, Kazuaki/0000-0002-5530-5341
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NR 39
TC 12
Z9 15
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1619-7070
EI 1619-7089
J9 EUR J NUCL MED MOL I
JI Eur. J. Nucl. Med. Mol. Imaging
PD FEB
PY 2010
VL 37
IS 2
BP 368
EP 376
DI 10.1007/s00259-009-1307-6
PG 9
WC Radiology, Nuclear Medicine & Medical Imaging
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Radiology, Nuclear Medicine & Medical Imaging
GA 552MC
UT WOS:000274293900019
PM 19915835
DA 2025-06-11
ER

PT J
AU Grootaert, MOJ
AF Grootaert, Mandy O. J.
TI Cell senescence in cardiometabolic diseases
SO NPJ AGING
LA English
DT Review
ID SMOOTH-MUSCLE-CELLS; TUBULAR EPITHELIAL-CELLS; SECRETORY PHENOTYPE;
   OXIDATIVE STRESS; DNA-DAMAGE; LIFE-SPAN; MITOCHONDRIAL DYSFUNCTION;
   REPLICATIVE SENESCENCE; PREMATURE SENESCENCE; CARDIOVASCULAR-DISEASE
AB Cellular senescence has been implicated in many age-related pathologies including atherosclerosis, heart failure, age-related cardiac remodeling, diabetic cardiomyopathy and the metabolic syndrome. Here, we will review the characteristics of senescent cells and their endogenous regulators, and summarize the metabolic stressors that induce cell senescence. We will discuss the evidence of cell senescence in the onset and progression of several cardiometabolic diseases and the therapeutic potential of anti-senescence therapies.
C1 [Grootaert, Mandy O. J.] UCLouvain, Endocrinol Diabet & Nutr, Brussels, Belgium.
   [Grootaert, Mandy O. J.] Katholieke Univ Leuven, Ctr Mol & Vasc Biol, Dept Cardiovasc Sci, Leuven, Belgium.
C3 Universite Catholique Louvain; KU Leuven
RP Grootaert, MOJ (corresponding author), UCLouvain, Endocrinol Diabet & Nutr, Brussels, Belgium.; Grootaert, MOJ (corresponding author), Katholieke Univ Leuven, Ctr Mol & Vasc Biol, Dept Cardiovasc Sci, Leuven, Belgium.
EM mandy.grootaert@uclouvain.be
FU IREC (Institut de Recherche Experimentale et Clinique) institute at
   UCLouvain
FX I would like to express my gratitude to the IREC (Institut de Recherche
   Experimentale et Clinique) institute at UCLouvain for their financial
   support for the publication of this article. Figures were created in
   Microsoft PowerPoint using images from Servier Medical Art licensed
   under CC BY 4.0.
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NR 174
TC 3
Z9 3
U1 1
U2 1
PU NATURE PUBL GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 2731-6068
J9 NPJ AGING
JI npj Aging
PD OCT 21
PY 2024
VL 10
IS 1
AR 46
DI 10.1038/s41514-024-00170-4
PG 14
WC Geriatrics & Gerontology
WE Emerging Sources Citation Index (ESCI)
SC Geriatrics & Gerontology
GA J5U9Y
UT WOS:001337727200001
PM 39433786
OA Green Accepted, hybrid
DA 2025-06-11
ER

PT J
AU Vekic, DA
   Frew, J
   Cains, GD
AF Vekic, Dunja Ana
   Frew, John
   Cains, Geoffrey David
TI Hidradenitis suppurativa, a review of pathogenesis, associations and
   management. Part 1
SO AUSTRALASIAN JOURNAL OF DERMATOLOGY
LA English
DT Review
DE autoinflammation; hidradenitis suppurativa
ID PYODERMA-GANGRENOSUM; METABOLIC SYNDROME; BACTERIAL BIOFILM;
   MECHANICAL-STRESS; DOWN-SYNDROME; ACNE INVERSA; PREVALENCE; SKIN;
   DISEASE; LESIONS
AB Hidradenitis suppurativa is a chronic, painful, autoinflammatory condition resulting in nodules, abscesses and sinus tracts. We present an evidence-based review providing new understanding of the pathogenesis of hidradenitis suppurativa and associated comorbidities. By the nature of their speciality, dermatologists are uniquely positioned to investigate and treat patients with this condition. Data collected from a subspecialty hidradenitis suppurativa clinic (N = 106) and experiences thereof are discussed in this review.
C1 [Vekic, Dunja Ana; Cains, Geoffrey David] Ingham Inst Appl Med Res, Sydney, NSW, Australia.
   [Vekic, Dunja Ana; Frew, John] Liverpool Hosp, Dept Dermatol, Sydney, NSW, Australia.
   [Vekic, Dunja Ana; Frew, John; Cains, Geoffrey David] Univ New South Wales, Sydney, NSW, Australia.
C3 Ingham Institute for Applied Medical Research; Liverpool Hospital;
   University of New South Wales Sydney
RP Vekic, DA (corresponding author), Ingham Inst Appl Med Res, Dermatol Res Grp, 1 Campbell St, Liverpool, NSW 2170, Australia.
EM dunja.vekic@health.nsw.gov.au
RI Frew, John/M-8446-2015; Vekic, Dunja/E-4657-2018
OI Frew, John/0000-0001-5042-3632; Vekic, Dunja/0000-0001-9412-1433
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NR 75
TC 34
Z9 35
U1 1
U2 14
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0004-8380
EI 1440-0960
J9 AUSTRALAS J DERMATOL
JI Australas. J. Dermatol.
PD NOV
PY 2018
VL 59
IS 4
BP 267
EP 277
DI 10.1111/ajd.12770
PG 11
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA GZ7TQ
UT WOS:000449686900008
PM 29355905
DA 2025-06-11
ER

PT J
AU Zhou, JL
   Meng, XJ
   Deng, LG
   Liu, N
AF Zhou, Jianli
   Meng, Xiaojing
   Deng, Lugang
   Liu, Nan
TI Non-linear associations between metabolic syndrome and four typical
   heavy metals: Data from NHANES 2011-2018
SO CHEMOSPHERE
LA English
DT Article
DE Heavy metals; Logistic regression; Metabolic syndrome; Restricted cubic
   splines
ID KOREA NATIONAL-HEALTH; OXIDATIVE STRESS; MERCURY LEVEL; US ADULTS; LEAD;
   TOXICITY; EXPOSURE; CADMIUM; BLOOD; MANGANESE
AB Previous studies have found that heavy metals are associated with metabolic syndrome (MetS), although findings are inconsistent. Further, investigations into potential associations that consider age-or gender-specific effects and dose-response associations for metal exposure and MetS are rare. In this study, we explore the associations between blood levels of typical heavy metals [lead (Pb), cadmium (Cd), mercury (Hg) and manganese (Mn)] and MetS among adults using logistic regression analysis and restricted cubic splines (RCS) logistic analysis using data from the US National Health and Nutrition Examination Survey 2011-2018. After adjusting for covariates, higher levels of blood Pb, Cd and Hg were associated with lower risks of MetS in participants overall, and in all subgroup analyses, by logistic regression analysis (all P-values <0.05); in contrast, higher levels of blood Mn had a higher risk of MetS only in the age group of 30-49 years (P-values <0.05). We also found non-linear associations of heavy metal levels in blood with risk of MetS in participants overall, in specific age groups and in both genders, using RCS logistic regressions (all P-values <0.05). In addition, the non-linear associations of Pb and Hg we observed in different subgroups differed. In conclusion, blood levels of four heavy metals were associated with the risk of MetS through a variety of non-linear patterns.
C1 [Zhou, Jianli; Meng, Xiaojing; Liu, Nan] Southern Med Univ, Sch Publ Hlth, Dept Occupat Hlth & Occupat Med, Guangzhou 510515, Peoples R China.
   [Deng, Lugang; Liu, Nan] Shenzhen Univ, South China Hosp, Hlth Sci Ctr, Inst Environm & Hlth, Shenzhen 518116, Peoples R China.
   [Liu, Nan] Henan Univ, Sch Nursing & Hlth, Inst Chron Dis Risks Assessment, Kaifeng 475004, Peoples R China.
   [Liu, Nan] Zhengzhou Univ, Coll Publ Hlth, Zhengzhou 540001, Peoples R China.
C3 Southern Medical University - China; Shenzhen University; Henan
   University; Zhengzhou University
RP Meng, XJ; Liu, N (corresponding author), Southern Med Univ, Sch Publ Hlth, Dept Occupat Hlth & Occupat Med, Guangzhou 510515, Peoples R China.
EM xiaojingmeng@smu.edu.cn; 13688869875@163.com
RI Liu, Nan/W-1842-2019; meng, xiaojing/B-7724-2019
OI Zhou, Jianli/0009-0002-7575-829X; Liu, Nan/0000-0002-8895-3169
FU National Natural Science Foundation of China [81872584, 81273078];
   National 863 Young Scientist Program [2015AA020940]; Natural Science
   Foundation of Guang-dong Province [2016A030313138]; Key Projects of
   Guangzhou Science and Technology Program [201704020056];
   Interdisci-plinary Research for First-class Discipline Construction
   Project of Henan University [2019YLXKJC04]; Scientific Research Project
   for Uni-versity of Education Bureau of Guangzhou [201831841]; Key
   Sci-entific Research Project Plan of Henan Province [21A330001]; Yellow
   River Scholar Fund of Henan University
FX This work was supported by National Natural Science Foundation of China
   (Nos. 81872584 and 81273078) , National 863 Young Scientist Program (No.
   2015AA020940) , Natural Science Foundation of Guang-dong Province (No.
   2016A030313138) , Key Projects of Guangzhou Science and Technology
   Program (No.201704020056) , Interdisci-plinary Research for First-class
   Discipline Construction Project of Henan University (No.2019YLXKJC04) ,
   Scientific Research Project for Uni-versity of Education Bureau of
   Guangzhou (No. 201831841) , Key Sci-entific Research Project Plan of
   Henan Province (No. 21A330001) and Yellow River Scholar Fund of Henan
   University.
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NR 50
TC 43
Z9 44
U1 0
U2 29
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0045-6535
EI 1879-1298
J9 CHEMOSPHERE
JI Chemosphere
PD MAR
PY 2022
VL 291
AR 132953
DI 10.1016/j.chemosphere.2021.132953
EA JAN 2022
PN 2
PG 9
WC Environmental Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology
GA ZD1XP
UT WOS:000757999100004
PM 34800500
DA 2025-06-11
ER

PT J
AU Padhar, BC
   Dave, AR
   Nariya, M
AF Padhar, Bharatkumar C.
   Dave, Alankruta R.
   Nariya, Mukeshkumar
TI Acute toxicity and anti-dyslipidemic activity of Arogyavardhini
   compound in fructose-induced dyslipidemia in albino rats
SO INDIAN JOURNAL OF NATURAL PRODUCTS AND RESOURCES
LA English
DT Article
DE Acute toxicity; Antidyslipidemic activity; Arogyavardhini compound;
   Fructose; Metabolic syndrome
ID EMBLICA-OFFICINALIS; OXIDATIVE STRESS; GALLIC ACID; INSULIN;
   CONSUMPTION; PARAMETERS; GAERTN.; ROXB.
AB Metabolic syndrome is a co-occurrence of obesity, insulin resistance, hypertension, and dyslipidemia caused by improper diet and lifestyle. Arogyavardhini compound (AVC) contains an equal quantity of Arogyavardhini rasa and Lasuna powder. In clinical practice, Arogyavardhini Rasa is well known for its antidyslipidemic and weight lowering effect. Therefore, the present experimental study was designed to evaluate the safety of AVC on acute administration and anti-dyslipidemic activity in albino rats. An acute oral toxicity study for AVC was carried out by following OECD 425 guidelines. The anti-dyslipidemic activity was carried out against fructose-induced dyslipidemia in albino rats. No mortality and toxicity were observed and gross behaviours of all the albino rats were found normal during the experimental period of 14 days in the acute toxicity study. Fructose significantly increased blood sugar, triglycerides, SGPT, and alkaline phosphatase levels in albino rats in comparison to the control group. AVC treated group produced a decrease in serum triglyceride, transaminases, and alkaline phosphatase, which suggest that the drug has potential as anti-dyslipidemic and may be protective for degenerative changes produced by fructose in the liver, kidney, and heart of albino rats. From the present study it is concluded that AVC is safe up to an oral dose of 2000 mg/kg in albino rats and has exhibited a protective role in fructose-induced dyslipidemia in albino rats, hence may be useful in metabolic syndrome.
C1 [Padhar, Bharatkumar C.] Natl Inst Ayurveda, PG Dept Kayachikitsa, Jaipur 302002, Rajasthan, India.
   [Dave, Alankruta R.] Inst Teaching & Res Ayurveda, Dept Kayachikitsa, Jamnagar 361008, Gujarat, India.
   [Nariya, Mukeshkumar] Inst Teaching & Res Ayurveda, Pharmacol Lab, Jamnagar 361008, Gujarat, India.
RP Nariya, M (corresponding author), Inst Teaching & Res Ayurveda, Pharmacol Lab, Jamnagar 361008, Gujarat, India.
EM mukeshnariya@gmail.com
RI Padhar, Dr. Bharatkumar/F-7098-2014
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NR 41
TC 1
Z9 1
U1 0
U2 0
PU NATL INST SCIENCE COMMUNICATION & INFORMATION RESOURCES-NISCAIR
PI NEW DELHI
PA DR K S KRISHNAN MARG, PUSA CAMPUS, NEW DELHI, 110 012, INDIA
SN 0976-0504
EI 0976-0512
J9 INDIAN J NAT PROD RE
JI Indian J. Nat. Prod. Resour.
PD SEP
PY 2021
VL 12
IS 3
BP 384
EP 390
PG 7
WC Plant Sciences
WE Emerging Sources Citation Index (ESCI)
SC Plant Sciences
GA WZ1KM
UT WOS:000719732000006
DA 2025-06-11
ER

PT J
AU Byrne, CD
   Targher, G
AF Byrne, Christopher D.
   Targher, Giovanni
TI NAFLD as a driver of chronic kidney disease
SO JOURNAL OF HEPATOLOGY
LA English
DT Review
DE Non-alcoholic fatty liver disease; Type 2 diabetes; Insulin resistance;
   Metabolic syndrome; Dysbiosis; Adipose tissue; Gut microbiota; CKD
ID FATTY LIVER-DISEASE; GAMMA-GLUTAMYL-TRANSFERASE; OXIDATIVE STRESS;
   CARDIOVASCULAR-DISEASE; ADIPOSE-TISSUE; INSULIN-RESISTANCE;
   GASTROINTESTINAL-TRACT; INTESTINAL MICROBIOTA; ACID CONCENTRATIONS;
   HEPATIC STEATOSIS
AB Non-alcoholic fatty liver disease (NAFLD) and chronic kidney disease (CKD) are worldwide public health problems, affecting up to 25-30% (NAFLD), and up to 10-15% (CKD) of the general population. Recently, it has also been established that there is a strong association between NAFLD and CKD, regardless of the presence of potential confounding diseases such as obesity, hypertension and type 2 diabetes. Since NAFLD and CKD are both common diseases that often occur alongside other metabolic conditions, such as type 2 diabetes or metabolic syndrome, elucidating the relative impact of NAFLD on the risk of incident CKD presents a substantial challenge for investigators working in this research field. A growing body of epidemiological evidence suggests that NAFLD is an independent risk factor for CKD and recent evidence also suggests that associated factors such as metabolic syndrome, dysbiosis, unhealthy diets, platelet activation and processes associated with ageing could also contribute mechanisms linking NAFLD and CKD. This narrative review provides an overview of the literature on: a) the evidence for an association and causal link between NAFLD and CKD and b) the underlying mechanisms by which NAFLD (and factors strongly linked with NAFLD) may increase the risk of developing CKD. (C) 2020 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
C1 [Byrne, Christopher D.] Univ Southampton, Fac Med, Nutr & Metab, Southampton SO16 6YD, Hants, England.
   [Byrne, Christopher D.] Univ Hosp Southampton, Southampton Natl Inst Hlth Res Biomed Res Ctr, Southampton, Hants, England.
   [Targher, Giovanni] Univ Verona, Dept Med, Div Endocrinol Diabet & Metab, Verona, Italy.
   [Targher, Giovanni] Azienda Osped Univ Integrata Verona, Verona, Italy.
C3 University of Southampton; University of Verona; University of Verona;
   Azienda Ospedaliera Universitaria Integrata Verona
RP Byrne, CD (corresponding author), Univ Southampton, Fac Med, Nutr & Metab, Southampton SO16 6YD, Hants, England.; Targher, G (corresponding author), Univ Verona, Dept Med, Div Endocrinol Diabet & Metab, Verona, Italy.; Targher, G (corresponding author), Azienda Osped Univ Integrata Verona, Verona, Italy.
EM cdtb@soton.ac.uk; giovanni.targher@univr.it
RI Targher, Giovanni/AAB-9008-2019
OI Targher, Giovanni/0000-0002-4325-3900; Byrne, Christopher
   D/0000-0001-6322-7753
FU Southampton NIHR Biomedical Research Centre, UK [IS-BRC-20004];
   University School of Medicine of Verona, Verona, Italy
FX C.D.B. is supported in part by the Southampton NIHR Biomedical Research
   Centre (IS-BRC-20004), UK. G.T. is supported in part by grants from the
   University School of Medicine of Verona, Verona, Italy.
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NR 142
TC 292
Z9 301
U1 2
U2 85
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0168-8278
EI 1600-0641
J9 J HEPATOL
JI J. Hepatol.
PD APR
PY 2020
VL 72
IS 4
BP 785
EP 801
DI 10.1016/j.jhep.2020.01.013
PG 17
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA KU9NH
UT WOS:000520050900022
PM 32059982
OA Green Accepted
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Romero-Nava, R
   Zhou, DS
   García, N
   Ruiz-Hernández, A
   Si, YC
   Sánchez-Muñoz, F
   Huang, FY
   Hong, E
   Villafaña, S
AF Romero-Nava, Rodrigo
   Zhou, De-Shan
   Garcia, Noemi
   Ruiz-Hernandez, Armando
   Si, Yin-Chu
   Sanchez-Munoz, Fausto
   Huang, Fengyang
   Hong, Enrique
   Villafana, Santiago
TI Evidence of alterations in the expression of orphan receptors GPR26 and
   GPR39 due to the etiology of the metabolic syndrome
SO JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION
LA English
DT Article
DE Metabolic syndrome; orphan receptors; GPR26; GPR39V1; GPR39V2
ID PROTEIN-COUPLED RECEPTOR; OXIDATIVE STRESS; INSULIN-RESISTANCE;
   ANGIOTENSIN-II; FRUCTOSE; MECHANISMS; GENE; HYPERTENSION; SYSTEM; TYPE-2
AB Aims: Metabolic syndrome (MS) is composed of several metabolic abnormalities that increase the risk of cardiovascular diseases and diabetes. Although there are treatments for the components of MS, this pathology maintains a high mortality, suggesting that there are other mechanisms in which orphan receptors such as GPR26 and GPR39 may be involved. For this reason, the aim of this work was to evaluate the expression of GPR26 and GPR39 orphan receptors in two models of MS (diet and genetics).
   Materials and methods: We used male Wistar rats, which received 70% fructose in drinking water for 9 weeks, and obese Zucker rats. We measured weight, blood pressure, glucose, triglycerides, total cholesterol, HDL cholesterol, LDL cholesterol to determine the MS and the expression of the orphan receptors GPR26 and GPR39 in brain, heart, aorta, liver, and kidney by RT-PCR.
   Results: The analysis of the expression of the orphan receptors GPR26 and GPR39 showed that the receptors are expressed in some tissues, but the expression of the GPR26 tends to decrease in the heart and aorta, whereas in the brain, no changes were observed, this receptor is not expressed in the liver and kidney of both strains. The expression of GPR39 isoforms depends on the tissue and MS model.
   Conclusions: We conclude that the orphan receptors GPR26, GPR39v1, and GPR39v2 are expressed in different tissues and their profile expression is dependent on the etiology of the MS.
C1 [Romero-Nava, Rodrigo; Ruiz-Hernandez, Armando; Villafana, Santiago] Inst Politecn Nacl, Lab Senalizac Intracelular, Escuela Super Med, Secc Posgrad, Mexico City, DF, Mexico.
   [Zhou, De-Shan] Capital Med Univ, Dept Histol & Embryol, Beijing, Peoples R China.
   [Garcia, Noemi] Tecnol Monterrey, Escuela Nacl Med, Monterrey, NL, Mexico.
   [Garcia, Noemi] Hosp Zambrano Hellio, Ctr Invest Basica & Transferencia, Garza Garcia, NL, Mexico.
   [Si, Yin-Chu] Beijing Univ Chinese Med, Dept Anat, Beijing, Peoples R China.
   [Sanchez-Munoz, Fausto] Inst Nacl Cardiol Ignacio Chavez, Dept Inmunol, Mexico City, DF, Mexico.
   [Huang, Fengyang] HIMFG, Dept Farmacol & Toxicol, Mexico City, DF, Mexico.
   [Hong, Enrique] Ctr Invest & Estudios Avanzados, Dept Farmacobiol, Mexico City, DF, Mexico.
C3 Instituto Politecnico Nacional - Mexico; Capital Medical University;
   Tecnologico de Monterrey; Beijing University of Chinese Medicine;
   National Institute of Cardiology - Mexico; CINVESTAV - Centro de
   Investigacion y de Estudios Avanzados del Instituto Politecnico Nacional
RP Villafaña, S (corresponding author), Inst Politecn Nacl, Lab Senalizac Intracelular, Escuela Super Med, Secc Posgrad, Mexico City, DF, Mexico.
EM svillafana@ipn.mx
RI Sanchez-Muñoz, Fausto/KIE-6221-2024; Huang, Fengyang/AAF-8605-2021;
   Garcia, Noemi/T-4688-2019
OI SANCHEZ-MUNOZ, FAUSTO/0000-0001-6556-1632; Ruiz Hernandez,
   Armando/0000-0002-3855-2981; Huang, Fengyang/0000-0002-6503-694X; Noemi,
   Garcia/0000-0002-1137-0117
FU Consejo Nacional de Ciencia y Tecnologia [CONACYT CB-1012-01-183660];
   Secretaria de Investigacion y Posgrado del Instituto Politecnico
   Nacional [SIP-IPN-20161519]; CONACYT scholarship [389327]
FX This work was supported by grants CONACYT CB-1012-01-183660 (Consejo
   Nacional de Ciencia y Tecnologia), project SIP-IPN-20161519 (Secretaria
   de Investigacion y Posgrado del Instituto Politecnico Nacional), and
   CONACYT scholarship to the student Rodrigo Romero Nava (389327).
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NR 78
TC 9
Z9 9
U1 0
U2 8
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1079-9893
EI 1532-4281
J9 J RECEPT SIG TRANSD
JI J. Recept. Signal Transduct.
PY 2017
VL 37
IS 4
BP 422
EP 429
DI 10.1080/10799893.2017.1298133
PG 8
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA EW3OP
UT WOS:000402409400013
PM 28270014
DA 2025-06-11
ER

PT J
AU Venturini, D
   Simao, ANC
   Dichi, I
AF Venturini, Danielle
   Colado Simao, Andrea Name
   Dichi, Isaias
TI Advanced oxidation protein products are more related to metabolic
   syndrome components than biomarkers of lipid peroxidation
SO NUTRITION RESEARCH
LA English
DT Article
DE Metabolic syndrome; Oxidative stress; Protein oxidation; Lipid
   peroxidation; Antioxidant defenses
ID TYPE-2 DIABETES-MELLITUS; C-REACTIVE PROTEIN; INSULIN-RESISTANCE;
   URIC-ACID; WAIST CIRCUMFERENCE; RISK-FACTORS; STRESS; ASSOCIATION;
   MANAGEMENT; STATEMENT
AB Although advanced oxidation protein products (AOPPs) have been reported as the most appropriate parameter for determination of oxidative stress in patients with metabolic syndrome (MetS), a direct comparison between protein and lipid peroxidation has not been performed yet. The aim of this study was to compare protein peroxidation with lipid peroxidation measured by 2 different methodologies (tert-butyl hydroperoxide-initiated chemiluminescence and ferrous oxidation-xylenol orange assay). The hypothesis of this study was that AOPPs would be more related to MetS than to oxidative markers of lipid peroxidation. This cross-sectional study evaluated 76 patients with MetS and 20 healthy subjects. Prooxidant-antioxidant index (PAI) assessed as AOPP/total radical-trapping antioxidant parameter ratio progressively increased (P<.05) according to the number of MetS components, whereas AOPPs and total radical-trapping antioxidant parameter increased (P<.05) when 5 components were compared with 3 components. Spearman test showed a positive correlation between AOPPs and waist circumference (r = 0.318, P<.01), fasting glucose (r = 0.250, P<.05), homeostasis model assessment insulin resistance (r = 0.043, P<.01), triacylglycerol (r = 0.713, P<.0001), highly sensitive C-reactive protein (r = 0.275, P<.05), and uric acid (r = 0.356, P<.01), whereas there was an inverse correlation with high-density lipoprotein cholesterol (r = -0.399, P<.001). Prooxidant-antioxidant index demonstrated a positive correlation with waist circumference (r = 0.386, P<.01), fasting glucose (r = 0.388, P<.01), fasting insulin (r = 0.344, P<.05), homeostasis model assessment insulin resistance (r = 0.519, P<.001), triacylglycerol (r = 0.687, P<.0001), highly sensitive C-reactive protein (r = 0.278, P<.05), and uric acid (r = 0.557, P<.0001), whereas there was an inverse correlation with high-density lipoprotein cholesterol (r = -0.480, P<.0001). In conclusion, protein peroxidation determined by AOPPs, and especially by PAL is more related to MetS components than lipid peroxidation. In addition, PAI progressively increased with the number of MetS components. (C) 2015 Elsevier Inc. All rights reserved.
C1 [Venturini, Danielle; Colado Simao, Andrea Name] Univ Londrina, Dept Pathol Clin Anal & Toxicol, BR-86038440 Londrina, Parana, Brazil.
   [Dichi, Isaias] Univ Londrina, Dept Internal Med, BR-86038440 Londrina, Parana, Brazil.
RP Simao, ANC (corresponding author), Univ Londrina, Dept Clin Pathol, Robert Koch Ave 60 Bairro Cervejaria, BR-86038440 Londrina, Parana, Brazil.
EM deianame@yahoo.com.br
RI Venturini, Danielle/HPH-1330-2023; Simão, Andrea/AAM-4892-2021
FU Research Funds of University of Londrina (FAEPE)
FX This study was financially supported by Research Funds of University of
   Londrina (FAEPE). The authors' responsibilities were as follows: D.V.
   and A.N.C.S. collected the data, designed the study, interpreted the
   results, wrote the manuscript, and performed the statistical analysis.
   I.D. developed the hypothesis tested in the study, designed the study,
   interpreted the results, and wrote the manuscript.
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NR 33
TC 25
Z9 26
U1 0
U2 12
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0271-5317
J9 NUTR RES
JI Nutr. Res.
PD SEP
PY 2015
VL 35
IS 9
BP 759
EP 765
DI 10.1016/j.nutres.2015.06.013
PG 7
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA CR5XE
UT WOS:000361416900002
PM 26255193
OA Bronze
DA 2025-06-11
ER

PT J
AU Han, X
   Wang, ZC
   Wang, J
   Li, YR
   Hu, H
   Hu, YJ
   Zhao, XY
   Zhan, Y
   Yuan, J
   Wei, S
   Liang, Y
   Zhang, XM
   Guo, H
   Yang, HD
   Wu, TC
   Kong, WJ
   He, MA
AF Han, Xu
   Wang, Zhichao
   Wang, Jing
   Li, Yaru
   Hu, Hua
   Hu, Yujuan
   Zhao, Xueyan
   Zhan, Yue
   Yuan, Jing
   Wei, Sheng
   Liang, Yuan
   Zhang, Xiaomin
   Guo, Huan
   Yang, Handong
   Wu, Tangchun
   Kong, Weijia
   He, Meian
TI Metabolic syndrome is associated with hearing loss among a middle-aged
   and older Chinese population: a cross-sectional study
SO ANNALS OF MEDICINE
LA English
DT Article
DE Central obesity; hearing loss; hyperglycemia; metabolic syndrome
ID NUTRITION EXAMINATION SURVEY; PLASMA ADIPONECTIN LEVELS; COCHLEAR
   FUNCTION; OXIDATIVE STRESS; NATIONAL-HEALTH; NITRIC-OXIDE; RISK-FACTORS;
   PREVALENCE; ADULTS; IMPAIRMENT
AB Background: Although the association of metabolic syndrome (MetS) and hearing loss has been evaluated, findings are controversial. This study investigated this association in a Chinese population.Methods: A cross-sectional study including a total of 18,824 middle-aged and older participants from the Dongfeng-Tongji Cohort study was conducted. Hearing loss was defined as the pure-tone average (PTA) of frequencies 0.5, 1.0, 2.0, and 4.0kHz>25 decibels hearing level (dB HL) in the better ear and graded as mild (PTA 26-40dB HL), moderate (PTA>40 to60dB HL), and severe (PTA>60dB HL). MetS was defined according to the International Diabetes Foundation (IDF) criteria of 2005. Association analysis was performed by logistic regression.Results: After adjustment for potential confounders, participants with MetS showed higher OR of hearing loss (OR, 1.11; 95% CI: 1.03-1.19). The MetS components including central obesity (OR, 1.07; 95% CI: 1.01-1.15) and hyperglycemia (OR, 1.12; 95% CI: 1.04-1.20) were also positively associated with hearing loss. Low HDL-C levels were also associated with higher OR of moderate/severe hearing loss (OR, 1.21; 95% CI: 1.07-1.36).Conclusions: The MetS, including its components central obesity, hyperglycemia, and low HDL-C levels were positively associated with hearing loss.
C1 [Han, Xu; Wang, Jing; Li, Yaru; Hu, Hua; Yuan, Jing; Wei, Sheng; Liang, Yuan; Zhang, Xiaomin; Guo, Huan; Wu, Tangchun; He, Meian] Huazhong Univ Sci & Technol, Sch Publ Hlth, Inst Occupat Med, Wuhan, Hubei, Peoples R China.
   [Han, Xu; Wang, Jing; Li, Yaru; Hu, Hua; Yuan, Jing; Wei, Sheng; Liang, Yuan; Zhang, Xiaomin; Guo, Huan; Wu, Tangchun; He, Meian] Huazhong Univ Sci & Technol, Sch Publ Hlth, Minist Educ, Key Lab Environm & Hlth, Wuhan, Hubei, Peoples R China.
   [Wang, Zhichao; Hu, Yujuan; Zhao, Xueyan; Zhan, Yue; Kong, Weijia] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Otorhinolaryngol, Wuhan, Hubei, Peoples R China.
   [Yang, Handong] Dongfeng Motor Corp, Dongfeng Cent Hosp, Shiyan, Hubei, Peoples R China.
   [Yang, Handong] Hubei Univ Med, Shiyan, Hubei, Peoples R China.
C3 Huazhong University of Science & Technology; Ministry of Education -
   China; Huazhong University of Science & Technology; Huazhong University
   of Science & Technology; Dongfeng Motor; Hubei University of Medicine
RP He, MA (corresponding author), Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, MOE Key Lab Environm & Hlth, 13 Hangkong Rd, Wuhan 430030, Hubei, Peoples R China.
EM hemeian@hotmail.com
RI wang, jing/GVT-8700-2022; Wang, Chenwei/HCI-8930-2022; zhao,
   xueyan/I-9434-2012; yu, ye/KVB-7532-2024; wei, sheng/E-9746-2012
OI Wang, Jing/0000-0003-4869-7719
FU National Natural Science Foundation [NSFC-81522040, 81230021, 81473051];
   National Key R&D Program of China [2017YFC0907501]; 111 Project
   [B12004]; Program for Changjiang Scholars; Innovative Research Team in
   University of Ministry of Education of China [IRT1246]; China Medical
   Board [12-113]; Program for HUST Academic Frontier Youth Team
FX This work was supported by the grant from the National Natural Science
   Foundation [Grants NSFC-81522040, 81230021, and 81473051]; National Key
   R&D Program of China [2017YFC0907501], the Program for HUST Academic
   Frontier Youth Team, the 111 Project (No. B12004); the Program for
   Changjiang Scholars; Innovative Research Team in University of Ministry
   of Education of China (No. IRT1246); and China Medical Board (No.
   12-113).
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NR 50
TC 23
Z9 25
U1 0
U2 16
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0785-3890
EI 1365-2060
J9 ANN MED
JI Ann. Med.
PY 2018
VL 50
IS 7
BP 587
EP 595
DI 10.1080/07853890.2018.1469786
PG 9
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA HL2TK
UT WOS:000458559600006
PM 29693425
OA Bronze
DA 2025-06-11
ER

PT J
AU Nagasawa, N
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   Kondo, T
   Toyoshima, H
AF Nagasawa, N
   Tamakoshi, K
   Yatsuya, H
   Hori, Y
   Ishikawa, M
   Murata, C
   Zhang, HM
   Wada, K
   Otsuka, R
   Mabuchi, T
   Kondo, T
   Toyoshima, H
TI Association of white blood cell count and clustered components of
   metabolic syndrome in Japanese men
SO CIRCULATION JOURNAL
LA English
DT Article
DE cardiovascular disease risk factor; Japanese men; low-grade
   inflammation; metabolic syndrome; white blood cell
ID CORONARY-HEART-DISEASE; C-REACTIVE PROTEIN; NECROSIS-FACTOR-ALPHA;
   LEUKOCYTE COUNT; CARDIOVASCULAR-DISEASE; RISK-FACTORS; ATHEROSCLEROSIS
   RISK; INSULIN-RESISTANCE; OXIDATIVE STRESS; INFLAMMATION
AB Background The role of inflammation in the genesis of cardiovascular disease has attracted attention and in the present study the association among metabolic syndrome (MS), white blood cell (WBC) count, and insulin concentration was investigated.
   Methods and Results A cross-sectional study of 3,594 Japanese men aged 34-69 years evaluated the MS components (high blood pressure, hypo-high density lipoprotein (HDL)-cholesterolemia, hypertriglyceridemia, hyperglycemia), as defined by the criteria given in the Third Report of the National Cholesterol Education Program Expert Panel on Detection Evaluation, and Treatment of High Blood Cholesterol in Adults, except for obesity [body mass index (BMI) greater than or equal to25 kg/m(2)]. WBC count had a positive correlation with BMI, blood pressure, triglyceride, glucose and insulin, and a negative correlation with HDL-cholesterol. The multi-adjusted means of WBC count and insulin concentration were significantly higher in MS subjects defined as having 3 or more of the components than in non-MS subjects with no more than 2 components. Both means also increased with the number of MS components (p<0.001 for trend). In the multiple linear regression analysis, BMI, HDL-cholesterol, systolic blood pressure, glucose and triglyceride had a significant and independent association with WBC count, but the insulin concentration did not.
   Conclusions The cluster of MS components based on insulin resistance may cause low-grade inflammation.
C1 Nagoya Univ, Grad Sch Med,Field Social Life Sci, Dept Publ Hlth Hlth Informat Dynam, Program Hlth & Community Med, Nagoya, Aichi 4668550, Japan.
   Nagoya Univ, Sch Hlth Sci, Dept Med Technol, Nagoya, Aichi 4668550, Japan.
C3 Nagoya University; Nagoya University
RP Nagoya Univ, Grad Sch Med, Dept Publ Hlth, Showa Ku, 65 Tsurumai Cho, Nagoya, Aichi 4668550, Japan.
EM toyosima@med.nagoya-u.ac.jp
RI Yatsuya, Hiroshi/L-4213-2016
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NR 38
TC 76
Z9 83
U1 0
U2 6
PU JAPANESE CIRCULATION SOC
PI TOYKO
PA 18TH FLOOR IMPERIAL HOTEL TOWER, 1-1-1 UCHISAIWAI-CHO CHIYODA-KU, TOYKO,
   100-0011, JAPAN
SN 1346-9843
EI 1347-4820
J9 CIRC J
JI Circ. J.
PD OCT
PY 2004
VL 68
IS 10
BP 892
EP 897
DI 10.1253/circj.68.892
PG 6
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 857VH
UT WOS:000224146600002
PM 15459460
OA Bronze
DA 2025-06-11
ER

PT J
AU Vancampfort, D
   De Hert, M
   Skjerven, LH
   Gyllensten, AL
   Parker, A
   Mulders, N
   Nyboe, L
   Spencer, F
   Probst, M
AF Vancampfort, Davy
   De Hert, Marc
   Skjerven, Liv Helvik
   Gyllensten, Amanda Lundvik
   Parker, Anne
   Mulders, Nathalie
   Nyboe, Lene
   Spencer, Felicity
   Probst, Michel
TI International Organization of Physical Therapy in Mental Health
   consensus on physical activity within multidisciplinary rehabilitation
   programmes for minimising cardio-metabolic risk in patients with
   schizophrenia
SO DISABILITY AND REHABILITATION
LA English
DT Review
DE Physical activity; physiotherapy; schizophrenia; guidelines
ID ATYPICAL ANTIPSYCHOTICS; CARDIOMETABOLIC RISK; PSYCHOTIC DISORDERS;
   CARDIOVASCULAR RISK; GUIDELINES; BARRIERS; EXERCISE; ILLNESS; HABITS;
   PEOPLE
AB Purpose: The excess cardiovascular morbidity associated with schizophrenia is attributed to an interplay between behavioural (physical inactivity, unhealthy diet, substance abuse), genetic and illness related factors, as well as the effects of antipsychotic treatment. Patients have limited access to physical healthcare with less opportunity for cardiovascular risk prevention and treatment programmes than the non-psychiatric population. The aim of this paper is to improve physical activity (PA) within rehabilitation programmes for people with schizophrenia. Method: The development process consisted of: a) systematic literature review on PA in schizophrenia in eight databases up to May 2010; b) review on existing national and international guidelines; c) consensus meetings, and d) formulation of the final consensus document. Results: There is insufficient evidence for the relative contribution of PA reducing cardio-metabolic risks in people with schizophrenia. Demographical, biological, psychological, cognitive-behavioural, emotional, social and environmental barriers for PA could be identified. Conclusions: Although PA outcomes on cardio-metabolic parameters are still unknown, the benefits of physical activity as part of a larger lifestyle programme are sufficient for the recommendation that persons with schizophrenia follow the 2008 U. S. Department of Health and Human Services PA Guidelines with specific adaptations based on disease and treatment-related adverse effects.
C1 [Vancampfort, Davy; De Hert, Marc; Probst, Michel] Katholieke Univ Leuven, Univ Psychiat Ctr, Kortenberg, Belgium.
   [Skjerven, Liv Helvik] Bergen Univ Coll, Fac Hlth & Sci, Dept Physiotherapy, Bergen, Norway.
   [Gyllensten, Amanda Lundvik] Lund Univ, Dept Hlth Sci, Div Physiotherapy, Lund, Sweden.
   [Parker, Anne] Royal Edinburgh & Associated Hosp, Edinburgh, Midlothian, Scotland.
   [Nyboe, Lene] Aarhus Univ Hosp, Ctr Psychiat Res, Risskov, Denmark.
   [Spencer, Felicity] Sydney Childrens Hosp, Sydney, NSW, Australia.
C3 KU Leuven; Western Norway University of Applied Sciences; Lund
   University; Royal Infirmary of Edinburgh; Aarhus University; University
   of Sydney; NSW Health; Sydney Childrens Hospitals Network
RP Vancampfort, D (corresponding author), Katholieke Univ Leuven, Univ Psychiat Ctr, Campus Kortenberg, Kortenberg, Belgium.
EM Davy.Vancampfort@uc-kortenberg.be
RI Probst, Michel/ABE-6137-2020; De Hert, Marc/AAH-6090-2021; Vancampfort,
   Davy/AAD-1987-2019
OI De Hert, Marc/0000-0003-4255-5920; Lundvik Gyllensten,
   Amanda/0000-0001-6289-9347; Nyboe, Lene/0000-0001-7131-3010
FU AstraZeneca; Lundbeck JA; Janssen-Cilag; Eli Lilly; Pfizer; Sanofi;
   Bristol-Myers Squibb
FX The Lund IOPTMH conference and Copenhagen board meeting were not
   supported by any sponsor. The organisers specifically excluded
   pharmaceutical industry employees in the conference consensus meeting on
   schizophrenia. In addition, all contributors disclosed potential
   conflicts of interest. Dr. M De Hert has been a consultant for, received
   grant/research support and honoraria from, and been on the
   speakers/advisory boards of AstraZeneca, Lundbeck JA, Janssen-Cilag, Eli
   Lilly, Pfizer, Sanofi and Bristol-Myers Squibb. The other authors
   declare that they have no conflicts of interest. The authors alone are
   responsible for the content and writing of the paper.
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NR 68
TC 111
Z9 118
U1 0
U2 36
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0963-8288
EI 1464-5165
J9 DISABIL REHABIL
JI Disabil. Rehabil.
PY 2012
VL 34
IS 1
BP 1
EP 12
DI 10.3109/09638288.2011.587090
PG 12
WC Rehabilitation
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Rehabilitation
GA 851LV
UT WOS:000297272600001
PM 21957908
DA 2025-06-11
ER

PT J
AU Sun, SJ
   Hu, FT
   Sang, YR
   Wang, S
   Liu, XC
   Shi, JF
   Cao, HJ
   Tao, FB
   Liu, KY
AF Sun, Shujing
   Hu, Fangting
   Sang, Yanru
   Wang, Sheng
   Liu, Xuechun
   Shi, Jiafeng
   Cao, Hongjuan
   Tao, Fangbiao
   Liu, Kaiyong
TI Dysregulated tryptophan metabolism contributes to metabolic syndrome in
   Chinese community-dwelling older adults
SO BMC ENDOCRINE DISORDERS
LA English
DT Article
DE Metabolic syndrome; Tryptophan; Metabolism; Older adults
ID POPULATION; DEFINITION; PREVALENCE; PATHWAY; AGE
AB BackgroundAs the prevalence of metabolic syndrome (MetS) rises among older adults, the associated risks of cardiovascular diseases and diabetes significantly increase, and it is closely linked to various metabolic processes in the body. Dysregulation of tryptophan (TRP) metabolism, particularly alterations in the kynurenine (KYN) and serotonin pathways, has been linked to the onset of chronic inflammation, oxidative stress, and insulin resistance, key contributors to the development of MetS. We aim to investigate the relationship between the TRP metabolites and the risk of MetS in older adults. MethodsUltra-performance liquid chromatography tandem mass spectrometry was used to detect TRP and its seven metabolites in a study involving 986 participants. Physical examination included the following indicators: blood pressure, body mass index, triglyceride levels, and high-density lipoprotein cholesterol (HDL-C) levels. Multiple linear regression, restricted cubic spline curve, binary logistic analysis, and sex-stratified analysis were used to explore the relationship between the metabolites and the risk of MetS in older adults. ResultsThe results indicated that, after adjusting for covariates, higher levels of TRP, KYN, kynurenic acid (KA), and xanthurenic acid (XA) were risk factors for MetS (P for trend < 0.05). By contrast, higher ratios of 5-hydroxytryptamine to TRP and indole-3-propionic acid to TRP were protective factors against MetS (P for trend < 0.05). ConclusionsTRP and its metabolites may serve as potential indicators for assessing and managing MetS in older adults, complementing existing biomarkers. Clinical trial numberNot applicable.
C1 [Sun, Shujing; Hu, Fangting; Sang, Yanru; Shi, Jiafeng; Tao, Fangbiao; Liu, Kaiyong] Anhui Med Univ, Sch Publ Hlth, 81 Meishan Rd, Hefei 230032, Anhui, Peoples R China.
   [Wang, Sheng] Anhui Med Univ, Ctr Sci Res, Hefei 230032, Anhui, Peoples R China.
   [Liu, Xuechun] Anhui Med Univ, Hefei Hosp, Hefei Peoples Hosp 2, Hefei 230011, Anhui, Peoples R China.
   [Cao, Hongjuan] Luan Ctr Dis Control & Prevent, Luan 237000, Anhui, Peoples R China.
   [Tao, Fangbiao; Liu, Kaiyong] Inst Hlth & Med, Ctr Big Data & Populat Hlth, Hefei 230032, Anhui, Peoples R China.
C3 Anhui Medical University; Anhui Medical University; Anhui Medical
   University
RP Liu, KY (corresponding author), Anhui Med Univ, Sch Publ Hlth, 81 Meishan Rd, Hefei 230032, Anhui, Peoples R China.; Liu, KY (corresponding author), Inst Hlth & Med, Ctr Big Data & Populat Hlth, Hefei 230032, Anhui, Peoples R China.
EM liukaiyong163@163.com
RI Sun, Shujing/KHW-1325-2024
FU MOE Key Laboratory of Population Health across Life Cycle
FX The authors would like to thank all the staff and students who
   contributed to the study. They would also like to thank all the study
   participants for their support. In addition, they would like to
   sincerely thank all the members of the experimental center platform of
   Anhui Medical University.
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NR 40
TC 1
Z9 1
U1 2
U2 2
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1472-6823
J9 BMC ENDOCR DISORD
JI BMC Endocr. Disord.
PD JAN 8
PY 2025
VL 25
IS 1
AR 7
DI 10.1186/s12902-024-01826-8
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA R8W0X
UT WOS:001394169900001
PM 39780122
OA gold
DA 2025-06-11
ER

PT J
AU Lancel, S
   Montaigne, D
   Marechal, X
   Marciniak, C
   Hassoun, SM
   Decoster, B
   Ballot, C
   Blazejewski, C
   Corseaux, D
   Lescure, B
   Motterlini, R
   Neviere, R
AF Lancel, Steve
   Montaigne, David
   Marechal, Xavier
   Marciniak, Camille
   Hassoun, Sidi Mohamed
   Decoster, Brigitte
   Ballot, Caroline
   Blazejewski, Caroline
   Corseaux, Delphine
   Lescure, Bernadette
   Motterlini, Roberto
   Neviere, Remi
TI Carbon Monoxide Improves Cardiac Function and Mitochondrial Population
   Quality in a Mouse Model of Metabolic Syndrome
SO PLOS ONE
LA English
DT Article
ID IN-VIVO; OXIDATIVE STRESS; HEME OXYGENASE-1; PROTEIN-KINASE; BIOGENESIS;
   MICE; AUTOPHAGY; EXPRESSION; MOLECULE; RESPIRATION
AB Aims: Metabolic syndrome induces cardiac dysfunction associated with mitochondria abnormalities. As low levels of carbon monoxide (CO) may improve myocardial and mitochondrial activities, we tested whether a CO-releasing molecule (CORM-3) reverses metabolic syndrome-induced cardiac alteration through changes in mitochondrial biogenesis, dynamics and autophagy.
   Methods and Results: Mice were fed with normal diet (ND) or high-fat diet (HFD) for twelve weeks. Then, mice received two intraperitoneal injections of CORM-3 (10 mg.kg(-1)), with the second one given 16 hours after the first. Contractile function in isolated hearts and mitochondrial parameters were evaluated 24 hours after the last injection. Mitochondrial population was explored by electron microscopy. Changes in mitochondrial dynamics, biogenesis and autophagy were assessed by western-blot and RT-qPCR. Left ventricular developed pressure was reduced in HFD hearts. Mitochondria from HFD hearts presented reduced membrane potential and diminished ADP-coupled respiration. CORM-3 restored both cardiac and mitochondrial functions. Size and number of mitochondria increased in the HFD hearts but not in the CORM-3-treated HFD group. CORM-3 modulated HFD-activated mitochondrial fusion and biogenesis signalling. While autophagy was not activated in the HFD group, CORM-3 increased the autophagy marker LC3-II. Finally, ex vivo experiments demonstrated that autophagy inhibition by 3-methyladenine abolished the cardioprotective effects of CORM-3.
   Conclusion: CORM-3 may modulate pathways controlling mitochondrial quality, thus leading to improvements of mitochondrial efficiency and HFD-induced cardiac dysfunction.
C1 [Lancel, Steve; Montaigne, David; Marechal, Xavier; Marciniak, Camille; Hassoun, Sidi Mohamed; Decoster, Brigitte; Ballot, Caroline; Blazejewski, Caroline; Neviere, Remi] Univ Lille 2, EA4484, Dept Physiol, Lille, France.
   [Corseaux, Delphine] Univ Lille 2, EA2693, Lille, France.
   [Lescure, Bernadette] Univ Paris 06, INSERM, IFR65, Irssa, Paris, France.
   [Motterlini, Roberto] Paris Est Univ, INSERM, U955, Fac Med, Creteil, France.
C3 Universite de Lille; Universite de Lille; Institut National de la Sante
   et de la Recherche Medicale (Inserm); Sorbonne Universite; Universite
   Paris-Est-Creteil-Val-de-Marne (UPEC); Institut National de la Sante et
   de la Recherche Medicale (Inserm)
RP Lancel, S (corresponding author), Univ Lille 2, EA4484, Dept Physiol, Lille, France.
EM steve.lancel@univ-lille2.fr
RI Marechal, Xavier/R-5762-2018; LANCEL, Steve/H-9047-2019; Motterlini,
   Roberto/Q-1890-2019; Motterlini, Roberto/G-2489-2013; montaigne,
   david/R-6066-2018; Corseaux, Delphine/R-4360-2018
OI Neviere, Remi/0000-0002-7966-0110; Lancel, Steve/0000-0002-3292-5433;
   Motterlini, Roberto/0000-0003-2684-2612; montaigne,
   david/0000-0002-2346-863X; Corseaux, Delphine/0000-0001-8642-1508
FU Universite Lille 2- Ministere de l'Enseignement Superieur et de la
   Recherche [EA4484]; CPER "cardiodiabete 2008'' - FEDER Region Nord
   Pas-de-Calais [08480265]; Fondation de France [2009002501]; Fondation
   Coeur et Arteres [FCA09T6]
FX This work was supported by EA4484- Universite Lille 2- Ministere de
   l'Enseignement Superieur et de la Recherche; CPER "cardiodiabete 2008''
   - FEDER Region Nord Pas-de-Calais 08480265; Fondation de France
   2009002501 and Fondation Coeur et Arteres FCA09T6. The funders had no
   role in study design, data collection and analysis, decision to publish,
   or preparation of the manuscript.
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NR 32
TC 53
Z9 61
U1 0
U2 8
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD AUG 1
PY 2012
VL 7
IS 8
AR e41836
DI 10.1371/journal.pone.0041836
PG 11
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 984SU
UT WOS:000307212800036
PM 22870253
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU de Oliveira, PRB
   da Costa, CA
   de Bem, GF
   de Cavalho, LCRM
   de Souza, MAV
   Neto, MD
   Sousa, PJD
   de Moura, RS
   Resende, AC
AF Braz de Oliveira, Paola Raquel
   da Costa, Cristiane Aguiar
   de Bem, Graziele Freitas
   Reis Marins de Cavalho, Lenize Costa
   Vieira de Souza, Marcelo Augusto
   de Lemos Neto, Miguel
   da Cunha Sousa, Pergentino Jose
   de Moura, Roberto Soares
   Resende, Angela Castro
TI Effects of an Extract Obtained From Fruits of Euterpe oleracea
   Mart. in the Components of Metabolic Syndrome Induced in C57BL/6J Mice
   Fed a High-fat Diet
SO JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
LA English
DT Article
DE Euterpe oleracea Mart.; Acai; metabolic syndrome; antioxidant; nitric
   oxide
ID INSULIN-RESISTANCE; ENDOTHELIAL DYSFUNCTION; OXIDATIVE STRESS; OBESITY;
   EXPRESSION; ADIPOSE; ANTHOCYANINS; ANTIOXIDANTS; PATHOGENESIS;
   STIMULATION
AB Previously, we have demonstrated that the seed of Euterpe oleracea Mart. (acai) from the Amazon region exerts vasodilator and antihypertensive actions. The aim of our study was to assess the effects of oral chronic treatment with acai seed extract (ASE, 300 mg.kg(-1).d(-1)) on high-fat (HF) diet-induced metabolic syndrome (MS) in C57BL/6J mice. Four groups of C57BL/6 mice were fed with control diet (10% fat), ASE (10% fat), HF (60% fat), and HF + ASE (60% fat plus ASE) for 12 weeks. The vasodilator effects of acetylcholine (ACh) and nitroglycerine (NG) were studied in perfused mesenteric arterial bed. Body weight, plasma total cholesterol, triglyceride, glucose and insulin levels, oral glucose tolerance test, and oxidative damage were determined, and the insulin resistance measured by Homeostatic Model Assessment (HOMA) index. Vasodilator response to ACh but not to NG was reduced in HF mice, and ASE restored the response. Increased plasma malondialdehyde levels, body weight, plasma triglyceride, total cholesterol, glucose levels, and insulin resistance were observed in HF mice and reduced by ASE. Treatment with ASE also reduced glucose intolerance observed by oral glucose tolerance test in HF mice. In conclusion, ASE protected C57BL/6J mice fed HF diet from phenotypic and metabolic characteristics of MS, providing an alternative nutritional resource for prevention of MS.
C1 [Braz de Oliveira, Paola Raquel; da Costa, Cristiane Aguiar; de Bem, Graziele Freitas; Reis Marins de Cavalho, Lenize Costa; Vieira de Souza, Marcelo Augusto; de Lemos Neto, Miguel; de Moura, Roberto Soares; Resende, Angela Castro] Univ Estado Rio de Janeiro, Dept Pharmacol, Inst Biol, BR-20551030 Rio De Janeiro, Brazil.
   [da Cunha Sousa, Pergentino Jose] Fed Univ Para, Dept Pharm, Amapa, Para, Brazil.
C3 Universidade do Estado do Rio de Janeiro; Universidade Federal do Para
RP Resende, AC (corresponding author), Univ Estado Rio de Janeiro, Dept Farmacol & Psicobiol, IB, Ave 28 Setembro,87, BR-20551030 Rio De Janeiro, Brazil.
EM angelacr@uerj.br
RI Resende, Angela/M-8632-2017; Costa, Cristiane/AAF-8475-2021; Souza,
   Marcelo/V-7696-2019; de Bem, Graziele/AAB-6394-2019
OI Aguiar da Costa, Cristiane/0000-0003-1927-1794; de Bem,
   Graziele/0000-0002-9094-1597
FU National Council of Scientific and Technological Development (Conselho
   Nacional de Desenvolvimento Cientifico e Tecnologico); Rio de Janeiro
   State Research Agency (Fundacao de Amparo a Pesquisa do Estado do Rio de
   Janeiro)
FX Sources of Support: This work was conducted with grants from National
   Council of Scientific and Technological Development (Conselho Nacional
   de Desenvolvimento Cientifico e Tecnologico) and Rio de Janeiro State
   Research Agency (Fundacao de Amparo a Pesquisa do Estado do Rio de
   Janeiro).
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NR 46
TC 35
Z9 38
U1 0
U2 16
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0160-2446
EI 1533-4023
J9 J CARDIOVASC PHARM
JI J. Cardiovasc. Pharmacol.
PD DEC
PY 2010
VL 56
IS 6
BP 619
EP 626
DI 10.1097/FJC.0b013e3181f78da4
PG 8
WC Cardiac & Cardiovascular Systems; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Pharmacology & Pharmacy
GA 692FI
UT WOS:000285138000007
PM 20838232
DA 2025-06-11
ER

PT J
AU Scuteri, A
   Najjar, SS
   Orru', M
   Usala, G
   Piras, MG
   Ferrucci, L
   Cao, A
   Schlessinger, D
   Uda, M
   Lakatta, EG
AF Scuteri, Angelo
   Najjar, Samer S.
   Orru', Marco
   Usala, Gianluca
   Piras, Maria Grazia
   Ferrucci, Luigi
   Cao, Antonio
   Schlessinger, David
   Uda, Manuela
   Lakatta, Edward G.
TI The central arterial burden of the metabolic syndrome is similar in men
   and women: the SardiNIA Study
SO EUROPEAN HEART JOURNAL
LA English
DT Article
DE Metabolic syndrome; Ageing; Gender; Arterial stiffness; Carotid IMT
ID EARLY CAROTID ATHEROSCLEROSIS; CARDIOVASCULAR RISK; STIFFNESS; DISEASE;
   ADULTS; AGE
AB We evaluated whether specific clusters of metabolic syndrome (MetS) components differentially impact on arterial structure and function, and whether the impact is similar in men and in women.
   Components of the MetS and arterial properties were assessed in 6148 subjects, aged 14-102 in a cluster of four towns in Sardinia, Italy. MetS was defined in accordance with the ATP III criteria. Age groups were classified as: < 35, 35-49, 50-64, and >= 65 years. Systolic blood pressure (BP), diastolic BP, pulse pressure, common carotid artery (CCA) diameter, intima-media thickness, distensibility, strain, stiffness index, wall stress, and aortic pulse wave velocity were measured. Common carotid artery plaque was defined as focal encroachment of the arterial wall and CCA calcification as acoustic shadowing. In any age group, subjects with MetS presented thicker, stiffer or less distensible, and wider large arteries than controls. The arterial burden of MetS increased as the number of altered MetS components increased. However, not all MetS components were associated with the same changes in arterial properties. In fact, specific clusters of MetS components, i.e. any combination of altered glucose tolerance, elevated BP, and elevated triglycerides (with or without abdominal obesity), dramatically increased age-associated arterial changes. The impact of MetS on arterial function was similar in men and women.
   MetS accelerates age-associated arterial changes, even in older persons. However, not all the clusters of MetS components render the same burden on arterial structure and function.
C1 [Scuteri, Angelo; Najjar, Samer S.; Lakatta, Edward G.] NIA, Cardiovasc Sci Lab, NIH, Baltimore, MD 21224 USA.
   [Scuteri, Angelo; Orru', Marco; Usala, Gianluca; Piras, Maria Grazia; Cao, Antonio; Uda, Manuela] Cittadella Univ Monserrato, CNR, INN, I-09042 Cagliari, Italy.
   [Ferrucci, Luigi] NIA, Longitudinal Study Sect, NIH, Baltimore, MD 21224 USA.
   [Schlessinger, David] NIA, Genet Lab, NIH, Baltimore, MD 21224 USA.
C3 National Institutes of Health (NIH) - USA; NIH National Institute on
   Aging (NIA); Consiglio Nazionale delle Ricerche (CNR); University of
   Cagliari; National Institutes of Health (NIH) - USA; NIH National
   Institute on Aging (NIA); National Institutes of Health (NIH) - USA; NIH
   National Institute on Aging (NIA)
RP Scuteri, A (corresponding author), IRCCS, INRCA, UO Geriatria, Via Cassia 1167, I-00189 Rome, Italy.
EM angeloelefante@interfree.it
RI Ferrucci, Luigi/AED-9724-2022; Lakatta, Edward/AAL-1447-2020; Uda,
   Manuela/AAC-2645-2019; piras, maria grazia/P-2061-2018
OI piras, maria grazia/0000-0001-9004-0900; Ferrucci,
   Luigi/0000-0002-6273-1613; SCUTERI, ANGELO/0000-0003-4784-5441; Lakatta,
   Edward/0000-0002-4772-0035; UDA, MANUELA/0000-0002-4890-6456
FU NIA [NO1-AG-1-2109]
FX The SardiNIA team was supported by Contract NO1-AG-1-2109 from the NIA.
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NR 24
TC 86
Z9 92
U1 1
U2 10
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0195-668X
EI 1522-9645
J9 EUR HEART J
JI Eur. Heart J.
PD MAR
PY 2010
VL 31
IS 5
BP 602
EP 613
DI 10.1093/eurheartj/ehp491
PG 12
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 564UA
UT WOS:000275241900020
PM 19942601
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Wang, YH
   Yang, H
   Meng, P
   Han, YS
AF Wang, Yuhong
   Yang, Hui
   Meng, Pan
   Han, Yuanshan
TI Association between low serum 25-hydroxyvitamin D and depression in a
   large sample of Chinese patients with type 2 diabetes mellitus
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Diabetes; Depression; 25-hydroxyvitamin D
ID VITAMIN-D LEVELS; OLDER-ADULTS; METABOLIC SYNDROME; GLYCEMIC CONTROL;
   RISK-FACTOR; US ADULTS; SYMPTOMS; METAANALYSIS; HEALTH; PREVALENCE
AB Background: Because of the absence of data on the direct association between vitamin D and depression in patients with diabetes, we examined the association between vitamin D state (assessed by 25-hydroxyvitamin D [ 25(OH) D]) and the prevalence of depression in adult patients with type 2 diabetes mellitus(T2DM).
   Method: Cross-sectional data were obtained from 2786 patients with T2DM recruited from a Chinese diabetes registry. Patients' records were reviewed to obtain data pertaining to age, sex, Body Mass Index (BMI), marital status, level of education, smoking status, duration of diabetes mellitus, use of insulin, and presence of additional illnesses. A multiple logistic regression analysis adjusted for potential confounders was used to assess independent associations between serum levels of 25 (OH) D and depression (defined by the Patient Health Questionnaire-9).
   Results: Using the PHQ-9 cutoff value of >= 10, 5.71% (159/2786; 95% CI: 4.85-6.57%) were considered to have depression. The serum 25(OH) D levels were significantly lower in diabetic patients with depression than those patients without depression [10.2(IQR, 7.6-15.2) ng/ml vs. 14.6(IQR, 10.7-19.8)ng/ml, respectively; P < 0.0001]. Multivariate logistic regression analysis considering traditional risk factors and other biomarkers showed an inverse relationship between serum 25 (OH) D levels and depression when serum 25 (OH) D were used as a continuous variable (OR, 0.84; 95% CI, 0.77-0.90; P < 0.001). Compared with the first quartile of serum 25 (OH) D levels, the second quartile OR for depression was 0.83 (95% CI, 0.75-0.92, P=0.012). For the third and fourth quartiles, it was 0.40 (95% CI, 0.33-0.52, P < 0.001) and 0.15 (95% CI, 0.08-0.22; P < 0.001), respectively.
   Conclusions: We observed a significant negative association between serum levels of 25 (OH) D and depression in Chinese patients with T2DM.
C1 [Wang, Yuhong; Meng, Pan] Hunan Univ Chinese Med, State Key Lab Chinese Med Powder & Med Innovat Hu, Xiangzui Rd, Changsha 410208, Hunan, Peoples R China.
   [Yang, Hui; Han, Yuanshan] Hunan Univ Chinese Med, Hosp 1, Cent Lab, Changsha 410007, Hunan, Peoples R China.
C3 Hunan University of Chinese Medicine; Hunan University of Chinese
   Medicine
RP Wang, YH (corresponding author), Hunan Univ Chinese Med, State Key Lab Chinese Med Powder & Med Innovat Hu, Xiangzui Rd, Changsha 410208, Hunan, Peoples R China.
EM washjonyck@163.com
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NR 40
TC 13
Z9 16
U1 0
U2 45
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD DEC 15
PY 2017
VL 224
SI SI
BP 56
EP 60
DI 10.1016/j.jad.2016.10.040
PG 5
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA FK3EL
UT WOS:000413368300008
PM 27816323
DA 2025-06-11
ER

PT J
AU Rubio-Ruiz, ME
   El Hafidi, M
   Pérez-Torres, I
   Baños, G
   Guarner, V
AF Rubio-Ruiz, M. E.
   El Hafidi, M.
   Perez-Torres, I.
   Banos, G.
   Guarner, V.
TI Medicinal Agents and Metabolic Syndrome
SO CURRENT MEDICINAL CHEMISTRY
LA English
DT Article
DE Anti-inflammatory drugs; anti-oxidant drugs; lifestyle changes;
   medicinal plants; metabolic syndrome; pharmacological agents
ID HIGH-FAT DIET; FACTOR-KAPPA-B; INSULIN-RESISTANCE; OXIDATIVE STRESS;
   SKELETAL-MUSCLE; BLOOD-PRESSURE; ANTIOXIDATIVE PROPERTIES; ENDOTHELIAL
   DYSFUNCTION; CARDIOVASCULAR-DISEASE; ESSENTIAL-HYPERTENSION
AB The definition of the Metabolic Syndrome (MS) has encountered difficulty in reaching a universal consensus although there exists an agreement of its main pathologies which are hypertension, obesity, dyslipidemia, insulin resistance, inflammation and renal damage. The prevalent opinion is that three of those alterations may define the syndrome. The incidence of the MS has increased globally, particularly in the last few years, to the point of being regarded as an epidemic. The treatment of the MS can be approached from different angles, since it may be a multifaceted health problem. A healthy lifestyle, which means the practice of regular exercise is suggested to MS patients. Increasing physical activity has anti-inflammatory effects since there is an inverse association of physical activity and inflammatory biomarker concentrations. An adequate diet is recommended, such as the Mediterranean, which contains fish, tomatoes, garlic, red peppers, olive oil and includes red wine, that is, antioxidants and non-saturated oils. There are also the traditional herbal preparations, used in the alternative medicine. Several therapeutic tools can be used; the most common are the pharmaceutical products to deal with obesity, hypertension, dyslipidemias, diabetes and inflammation. In addition several pharmacological therapies such as non steroidal anti-inflammatory drugs are recommended. Recently new mechanisms of action of statins, fibrates, metformin and thiazolidinediones have demonstrated their anti-inflammatory effect and potential use to treat MS.
C1 [Rubio-Ruiz, M. E.; Guarner, V.] Inst Nacl Cardiol Ignacio Chavez, Dept Fisiol, Tlalpan 14080, DF, Mexico.
   [El Hafidi, M.; Banos, G.] Inst Nacl Cardiol Ignacio Chavez, Dept Cardiovasc Biomed, Tlalpan 14080, DF, Mexico.
   [Perez-Torres, I.] Inst Nacl Cardiol Ignacio Chavez, Dept Pathol, Tlalpan 14080, DF, Mexico.
C3 National Institute of Cardiology - Mexico; National Institute of
   Cardiology - Mexico; National Institute of Cardiology - Mexico
RP Guarner, V (corresponding author), Inst Nacl Cardiol Ignacio Chavez, Dept Fisiol, Juan Badiano 1, Tlalpan 14080, DF, Mexico.
EM gualanv@yahoo.com
RI El-Hafidi, Mohammed/AAN-4083-2021; Pérez Torres, Israel/AAE-2579-2022;
   Guarner-Lans, Verónica/AFW-3723-2022
OI Rubio-Ruiz, Maria Esther/0000-0002-8844-2078; Perez-Torres,
   Israel/0000-0001-6510-2954; Guarner-Lans, Veronica/0000-0002-2655-7590
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NR 113
TC 21
Z9 21
U1 0
U2 37
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 0929-8673
EI 1875-533X
J9 CURR MED CHEM
JI Curr. Med. Chem.
PD JUL
PY 2013
VL 20
IS 21
BP 2626
EP 2640
DI 10.2174/0929867311320210002
PG 15
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Pharmacology &
   Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
GA 160ZB
UT WOS:000320158000002
PM 23590715
DA 2025-06-11
ER

PT J
AU Hubar, AO
   Bilai, AI
   Bilai, M
AF Hubar, A. O.
   Bilai, A. I.
   Bilai, M.
TI Modern aspects of comorbidity of urological disease and metabolic
   syndrome
SO ZAPOROZHYE MEDICAL JOURNAL
LA English
DT Review
DE Key urolithiasis; metabolic syndrome; obesity; mellitus diabetes;
   hyperuricemia; oxidative stress
ID EAU GUIDELINES; OBESITY; MANAGEMENT; DIAGNOSIS; RISK
AB Urinary stone disease (USD) is one of the most common urological diseases occurring mainly in people of working age. USD is associated with metabolic disorders, the causes of which include endogenous and exogenous factors. Metabolic syndrome (MS) is a "non-infectious epidemic" that manifests itself in diabetes, hypertension, atherosclerosis, and obesity. The bidirectionality of metabolic processes is an important factor of USD and MS. Aim. The paper aims at reviewing modern literary sources regarding the determination of pathogenetic links between the comorbidity of USD and MS. Results. Nephrolithiasis spreads and recurs simultaneously with obesity. A decrease in urine pH, which is the basis for the formation of urate stones, is associated with the presence of obesity, insulin resistance, and MS. Under such conditions, urine alkalinization is the main treatment for urolithiasis. The risk of stone formation increases when the body mass index is more than 30 kg/m2. Among patients with insulin resistance, nephrolithiasis is more severe, and kidney stones occur more often. The relationship between the hypertensive component of MS and USD has been established. Disorders of lipid metabolism have a negative prognosis, causing physicochemical aberrations in urine and the development of nephrolithiasis. Hyperuricemia is related to both the ability of insulin to reduce uric acid clearance in the proximal renal tubules and insulin resistance. The link between USD and chronic inflammation is based on an increase in the endogenous synthesis of oxalates from endogenous glycogenic amino acids, which leads to the development of hyperoxaluria in patients with MS. Clinical studies show the formation of kidney stones in conditions of oxidative stress, an association between stone formation and the development of MS, coronary heart disease, arterial hypertension, which is the result of common pathogenetic characteristics. Conclusions. The comorbidity of USD and MS is a systemic disorder. Kidney stone formation is associated with a decrease in urine pH against the background of MS. Hyperuricemia is comorbid with insulin resistance, dyslipoproteinemia, arterial hypertension, and abdominal obesity. Systemic chronic inflammation, comorbid with obesity and USD, based on an increase in the endogenous synthesis of oxalates from endogenous glycogenic amino acids. Oxidative stress has a common pathogenetic link between stone formation and insulin resistance, atherosclerosis, hypertension, and obesity.
C1 [Hubar, A. O.] Zaporizhzhia State Med Univ, Dept Urol, Zaporizhia, Ukraine.
   [Bilai, A. I.] Zaporizhzhia State Med Univ, Dept Fac Surg, Zaporizhia, Ukraine.
   [Bilai, M.] Zaporizhzhia State Med Univ, Dept Clin Pharm Pharmacotherapy Pharmacognosy & Ph, Zaporizhia, Ukraine.
C3 Zaporizhzhia State Medical University; Zaporizhzhia State Medical
   University; Zaporizhzhia State Medical University
RP Bilai, M (corresponding author), Zaporizhzhia State Med Univ, Dept Clin Pharm Pharmacotherapy Pharmacognosy & Ph, Zaporizhia, Ukraine.
EM belay250455@gmail.com
RI Bilai, Andrii/AAA-2225-2019
OI Bilai, Andrii/0000-0001-7510-6684
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NR 30
TC 0
Z9 0
U1 0
U2 3
PU ZAPORIZHZHYA STATE MEDICAL UNIV
PI ZAPORIZHZHYA
PA PR-KT MAYAKOVSKOGO, 26, ZAPORIZHZHYA, 69035, UKRAINE
SN 2306-4145
EI 2310-1210
J9 ZAPOROZHYE MED J
JI ZAPOROZHYE MED. J.
PD NOV-DEC
PY 2022
VL 24
IS 6
BP 742
EP 747
DI 10.14739/2310-1210.2022.6.266232
PG 6
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA 7R7LT
UT WOS:000910251900016
OA gold
DA 2025-06-11
ER

PT J
AU Lathigara, D
   Kaushal, D
   Wilson, RB
AF Lathigara, Dhruvi
   Kaushal, Devesh
   Wilson, Robert Beaumont
TI Molecular Mechanisms of Western Diet-Induced Obesity and Obesity-Related
   Carcinogenesis-A Narrative Review
SO METABOLITES
LA English
DT Review
DE bariatric surgery; breast cancer; colorectal carcinoma; crown-like
   structure (CLS); cytokine; exosome; GLP-1; HIF-1 alpha; hypoxia; leptin;
   macrophage polarization; metabolic syndrome; NASH; obesity; senescence
ID BODY-MASS INDEX; ADIPOSE-TISSUE; BREAST-CANCER; BARIATRIC SURGERY;
   HEPATOCELLULAR-CARCINOMA; METABOLIC SYNDROME; DNA METHYLATION;
   WEIGHT-LOSS; RISK; ASSOCIATION
AB The present study aims to provide a narrative review of the molecular mechanisms of Western diet-induced obesity and obesity-related carcinogenesis. A literature search of the Cochrane Library, Embase and Pubmed databases, Google Scholar and the grey literature was conducted. Most of the molecular mechanisms that induce obesity are also involved in the twelve Hallmarks of Cancer, with the fundamental process being the consumption of a highly processed, energy-dense diet and the deposition of fat in white adipose tissue and the liver. The generation of crown-like structures, with macrophages surrounding senescent or necrotic adipocytes or hepatocytes, leads to a perpetual state of chronic inflammation, oxidative stress, hyperinsulinaemia, aromatase activity, activation of oncogenic pathways and loss of normal homeostasis. Metabolic reprogramming, epithelial mesenchymal transition, HIF-1a signalling, angiogenesis and loss of normal host immune-surveillance are particularly important. Obesity-associated carcinogenesis is closely related to metabolic syndrome, hypoxia, visceral adipose tissue dysfunction, oestrogen synthesis and detrimental cytokine, adipokine and exosomal miRNA release. This is particularly important in the pathogenesis of oestrogen-sensitive cancers, including breast, endometrial, ovarian and thyroid cancer, but also 'non-hormonal' obesity-associated cancers such as cardio-oesophageal, colorectal, renal, pancreatic, gallbladder and hepatocellular adenocarcinoma. Effective weight loss interventions may improve the future incidence of overall and obesity-associated cancer.
C1 [Lathigara, Dhruvi; Kaushal, Devesh] UWS, Campbelltown Hosp, Dept Gen Surg, Campbelltown, NSW 2560, Australia.
   [Wilson, Robert Beaumont] UNSW, Liverpool Hosp, Dept Upper Gastrointestinal Surg, Liverpool, NSW 2170, Australia.
C3 NSW Health; Campbelltown Hospital; University of New South Wales Sydney;
   Liverpool Hospital
RP Wilson, RB (corresponding author), UNSW, Liverpool Hosp, Dept Upper Gastrointestinal Surg, Liverpool, NSW 2170, Australia.
EM robert.wilson@unsw.edu.au
OI Wilson, Robert/0000-0002-7408-4695
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NR 228
TC 27
Z9 27
U1 3
U2 16
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2218-1989
J9 METABOLITES
JI Metabolites
PD MAY 21
PY 2023
VL 13
IS 5
AR 675
DI 10.3390/metabo13050675
PG 46
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA H7LR7
UT WOS:000997739800001
PM 37233716
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Chen, JL
   Guo, J
   Lin, CX
   Yang, JD
   Mao, P
   Jiang, S
   He, W
   Lien, K
AF Chen, Jyu-Lin
   Guo, Jia
   Lin, Chen-Xi
   Yang, Jundi
   Mao, Ping
   Jiang, Shan
   He, Wei
   Lien, Kathy
TI Behavior Characteristics and Risk for Metabolic Syndrome Among Women in
   Rural Communities in China
SO JOURNAL OF CARDIOVASCULAR NURSING
LA English
DT Article
DE BMI; menopausal; metabolic syndrome; obesity; rural China
ID ADULTS; ASSOCIATION; PREVALENCE; OBESITY; DURATION; SEX; POPULATION;
   PREVENTION; MENOPAUSE; DISEASE
AB Background Rapid economic growth and lifestyle changes in China have resulted in increased metabolic syndrome (MetS) rates. Few investigators have examined sex-specific risk factors and the role of menopause, stress, and sleep on MetS among women in China. Objective In this study, we aimed to identify the risk factors for MetS among women in rural China. Methods A cross-sectional study design was used, and participants were recruited from rural areas in China. Female participants older than 18 years were eligible to participate. Participants had their weight, height, waist circumference, blood pressure, and fasting blood measured at study sites. They also completed validated questionnaires regarding sociodemographic information and MetS-related health behaviors. Results A total of 646 women were included in this study. The overall prevalence of MetS was 26.2%. The MetS group had a greater number of overweight/obese women than the non-MetS group did. For premenopausal women, a higher income, being overweight/obese, and eating salty/marinated food increased their risk for MetS (odds ratio [OR], 2.56, 4.55, and 3.1, respectively). For postmenopausal women, a low level of education (OR, 0.44) and being overweight/obese (OR, 4.98) increased their risk of MetS. Conclusion Almost half of the women in this study were overweight/obese, and many of them did not meet the national recommendations for a healthy lifestyle, increasing their risk for MetS. Developing cultural and behavioral interventions tailored for overweight/obese women is critical in reducing MetS.
C1 [Chen, Jyu-Lin; Lien, Kathy] Univ Calif San Francisco, Sch Nursing, Dept Family Hlth Care Nursing, San Francisco, CA 94143 USA.
   [Guo, Jia; Yang, Jundi; Jiang, Shan; He, Wei] Cent South Univ, Xiangya Sch Nursing, Changsha, Peoples R China.
   [Lin, Chen-Xi] Univ Calif San Francisco, Sch Nursing, San Francisco, CA 94143 USA.
   [Mao, Ping] Cent South Univ, Xiangya Hosp 3, Nursing Dept, 138 Tongzipo Rd, Changsha 410013, Peoples R China.
   [He, Wei] Cent South Univ, Xiangya Hosp 3, Changsha, Peoples R China.
C3 University of California System; University of California San Francisco;
   Central South University; University of California System; University of
   California San Francisco; Central South University; Central South
   University
RP Mao, P (corresponding author), Cent South Univ, Xiangya Hosp 3, Nursing Dept, 138 Tongzipo Rd, Changsha 410013, Peoples R China.
EM ping.mao@csu.edu.cn
RI He, Wei/C-7426-2015; Mao, Ping/M-1505-2016; Jiang, Shan/AAR-4396-2021
OI Guo, Jia/0000-0002-8304-9947
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NR 67
TC 2
Z9 2
U1 0
U2 10
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0889-4655
EI 1550-5049
J9 J CARDIOVASC NURS
JI J. Cardiovasc. Nurs.
PD SEP-OCT
PY 2022
VL 37
IS 5
BP 490
EP 498
DI 10.1097/JCN.0000000000000836
PG 9
WC Cardiac & Cardiovascular Systems; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Cardiovascular System & Cardiology; Nursing
GA 3R3LP
UT WOS:000838819000021
PM 34321435
DA 2025-06-11
ER

PT J
AU Paavola, T
   Bergmann, U
   Kuusisto, S
   Kakko, S
   Savolainen, MJ
   Salonurmi, T
AF Paavola, Timo
   Bergmann, Ulrich
   Kuusisto, Sanna
   Kakko, Sakari
   Savolainen, Markku J.
   Salonurmi, Tuire
TI Distinct Fatty Acid Compositions of HDL Phospholipids Are Characteristic
   of Metabolic Syndrome and Premature Coronary Heart Disease-Family Study
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE coronary heart disease; metabolic syndrome; HDL subfraction; lipidomics;
   phospholipid; mass spectrometry
ID HIGH-DENSITY-LIPOPROTEIN; OXIDATIVE STRESS; ARTERY-DISEASE; PLASMA;
   INFLAMMATION; CHOLESTEROL; LIPIDOME; SPHINGOMYELIN; MARKERS; SERUM
AB HDL particles can be structurally modified in atherosclerotic disorders associated with low HDL cholesterol level (HDL-C). We studied whether the lipidome of the main phosphatidylcholine (PC), lysophosphatidylcholine (LPC) and sphingomyelin (SM) species of HDL2 and HDL3 subfractions is associated with premature coronary heart disease (CHD) or metabolic syndrome (MetS) in families where common low HDL-C predisposes to premature CHD. The lipidome was analyzed by LC-MS. Lysophosphatidylcholines were depleted of linoleic acid relative to more saturated and shorter-chained acids containing species in MetS compared with non-affected subjects: the ratio of palmitic to linoleic acid was elevated by more than 30%. A minor PC (16:0/16:1) was elevated (28-40%) in MetS. The contents of oleic acid containing PCs were elevated relative to linoleic acid containing PCs in MetS; the ratio of PC (16:0/18:1) to PC (16:0/18:2) was elevated by 11-16%. Certain PC and SM ratios, e.g., PC (18:0/20:3) to PC (16:0/18:2) and a minor SM 36:2 to an abundant SM 34:1, were higher (11-36%) in MetS and CHD. The fatty acid composition of certain LPCs and PCs displayed a characteristic pattern in MetS, enriched with palmitic, palmitoleic or oleic acids relative to linoleic acid. Certain PC and SM ratios related consistently to CHD and MetS.
C1 [Paavola, Timo; Kakko, Sakari; Savolainen, Markku J.; Salonurmi, Tuire] Oulu Univ Hosp, Dept Internal Med, Res Ctr Internal Med, Oulu 90200, Finland.
   [Paavola, Timo; Kakko, Sakari; Savolainen, Markku J.; Salonurmi, Tuire] Univ Oulu, Oulu 90200, Finland.
   [Paavola, Timo; Kakko, Sakari; Savolainen, Markku J.; Salonurmi, Tuire] Oulu Univ Hosp, Med Res Ctr Oulu, Oulu 90200, Finland.
   [Bergmann, Ulrich] Univ Oulu, Bioctr Oulu, Prot Anal Core Facil, Oulu, Finland.
   [Kuusisto, Sanna] Univ Oulu, Bioctr Oulu, Fac Med, Computat Med, Oulu 90570, Finland.
   [Kuusisto, Sanna] Univ Eastern Finland, Sch Pharm, NMR Metabol Lab, Kuopio 70210, Finland.
C3 University of Oulu; University of Oulu; University of Oulu; University
   of Oulu; University of Eastern Finland
RP Salonurmi, T (corresponding author), Oulu Univ Hosp, Dept Internal Med, Res Ctr Internal Med, Oulu 90200, Finland.; Salonurmi, T (corresponding author), Univ Oulu, Oulu 90200, Finland.; Salonurmi, T (corresponding author), Oulu Univ Hosp, Med Res Ctr Oulu, Oulu 90200, Finland.
EM timo.paavola@student.oulu.fi; ulrich.bergmann@oulu.fi;
   sanna.kuusisto@uef.fi; sakari.kakko@oulu.fi; markku.savolainen@oulu.fi;
   tuire.salonurmi@oulu.fi
RI ; Salonurmi, Tuire/L-3637-2018
OI Savolainen, Markku/0000-0002-2557-6423; Kuusisto,
   Sanna/0000-0002-4468-7057; Salonurmi, Tuire/0000-0001-5104-5792
FU Sigrid Juselius Foundation; Laaketieteen lisensiaatti Paavo Ilmari
   Ahvenaisen saatio; Finnish Cultural Foundation; Finnish Foundation for
   Cardiovascular Research; Paavo Nurmi Foundation; Aarne Koskelo
   Foundation; Finnish Medical Foundation
FX This research was funded by Sigrid Juselius Foundation (to M.J.S.),
   Laaketieteen lisensiaatti Paavo Ilmari Ahvenaisen saatio (to T.P.), the
   Finnish Cultural Foundation (to T.P.), the Finnish Foundation for
   Cardiovascular Research (to M.J.S. and to T.P.), Paavo Nurmi Foundation
   (to T.P.), Aarne Koskelo Foundation (to T.P.) and the Finnish Medical
   Foundation (to T.P.).
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NR 54
TC 11
Z9 11
U1 2
U2 11
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD MAY
PY 2021
VL 22
IS 9
AR 4908
DI 10.3390/ijms22094908
PG 17
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA SB9XV
UT WOS:000650338900001
PM 34066314
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Tokgöz, HB
   Altan, F
AF Tokgoz, Hilal Busra
   Altan, Filiz
TI Hypericum perforatum L.: a medicinal plant with potential as a
   curative agent against obesity-associated complications
SO MOLECULAR BIOLOGY REPORTS
LA English
DT Article
DE Hypericum perforatum L; Insulin resistance; Inflammation; Obesity;
   Medicinal plants
ID HIGH-FAT-DIET; TISSUE LIPOPROTEIN-LIPASE; ADIPOSE-TISSUE;
   INSULIN-RESISTANCE; IN-VIVO; ADIPOCYTE DIFFERENTIATION;
   PHENOLIC-COMPOUNDS; GREEN TEA; EXTRACT; GENE
AB Obesity is a low-grade inflammatory disease that is getting increasingly common among adults and children and causes different complications. Insulin resistance, Type II diabetes, atherosclerosis, metabolic syndrome and hypertension are among the major health problems, that are associated with obesity. Some medications are used to treat obese individuals and metabolic surgery is recommended, if appropriate, for individuals with a BMI >= 40. Due to the fact that medications and metabolic surgery are not tolerated by all, researchers focus on alternative therapies. Medicinal plants comprise the most important group of these alternative treatments. Hypericum perforatum L. is the medicinal plant, which we focused on in this study. Hypericum perforatum L. has been recognized as a medicinally valuable plant for over 2000 years. It has been used for generations to treat anxiety, depression, insomnia, gastritis, hemorrhoids, wounds, and burns. Recent studies have indeed shown promising effects for the treatment of obesity. In this study, 3T3-L1 adipocytes were used to mimic the adipocyte differentiation associated with obesity in cellular terms. Lipoprotein lipase (Lpl), Diacylglycerol-O-acyltransferase 1 (Dgat1), Fatty acid synthase (Fasn) markers were used to study the lipid accumulation, and Collagen V (ColV) was used to study cell elasticity to investigate the relationship of the effects of the administration of Hypericum perforatum L. with obesity.
C1 [Tokgoz, Hilal Busra; Altan, Filiz] Mugla Sitki Kocman Univ, Dept Mol Biol & Genet, Fac Sci, TR-48000 Kotekli, Mugla, Turkey.
C3 Mugla Sitki Kocman University
RP Altan, F (corresponding author), Mugla Sitki Kocman Univ, Dept Mol Biol & Genet, Fac Sci, TR-48000 Kotekli, Mugla, Turkey.
EM afiliz@mu.edu.tr
RI Tokgöz, Hilal Büşra/AAX-1427-2021; ALTAN, Filiz/AAX-1445-2021
OI Tokgoz, Hilal Busra/0000-0002-0940-7427; Altan,
   Filiz/0000-0001-6358-2448
FU Scientific Resarch Project (BAP) Grant from the Mula Stk Kocman
   University [AR-GE 17/059]
FX This work was supported by the Scientific Resarch Project (BAP) Grant
   (AR-GE 17/059) from the Mula Stk Kocman University granted to Dr. Filiz
   ALTAN. Authors would like to thank to Dr. Reat uNAL for valuable
   scientific support and critical reading; to Dr. Zekiye Buket YILMAZ for
   critical reading and language editing; to Dr. Guven GoRK and Dr. Olcay
   CEYLAN for providing the plant material and to Dr. Mehmet VAROL for his
   expertise and assistance in technical editing.
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NR 36
TC 12
Z9 13
U1 3
U2 42
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0301-4851
EI 1573-4978
J9 MOL BIOL REP
JI Mol. Biol. Rep.
PD NOV
PY 2020
VL 47
IS 11
BP 8679
EP 8686
DI 10.1007/s11033-020-05912-7
EA OCT 2020
PG 8
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA PB8WL
UT WOS:000581562900002
PM 33090307
DA 2025-06-11
ER

PT J
AU Chalmers, L
   Kaskel, FJ
   Bamgbola, O
AF Chalmers, Laura
   Kaskel, Fredrick J.
   Bamgbola, Oluwatoyin
TI The role of obesity and its bioclinical correlates in the progression of
   chronic kidney disease
SO ADVANCES IN CHRONIC KIDNEY DISEASE
LA English
DT Review
DE obesity; chronic kidney disease; metabolic syndrome; insulin resistance
ID BODY-MASS INDEX; MESSENGER-RNA ABUNDANCE; LOWERS BLOOD-PRESSURE;
   CHRONIC-RENAL-FAILURE; OXIDATIVE STRESS; INSULIN-RESISTANCE;
   WEIGHT-LOSS; METABOLIC SYNDROME; GROWTH-HORMONE; PLASMA LEPTIN
AB In spite of a progressive fall in the incidence of traditional risk factors of cardiovascular morbidity (cigarette smoking, high blood pressure, and hyperlipidemia), there is an upward trend in the prevalence of obesity and chronic kidney disease (CKD). Furthermore, there is a strong correlation between body mass indices and the relative risk of progression of CKD. The close biophysiological interaction between obesity and CKD is evident by a similar occurrence of comorbidities including insulin resistance, hyperlipidermia, endothelial dysfunction, and sleep disorders. Truncal obesity is a primary component of metabolic syndrome; unlike peripheral fat, the visceral adipocytes are more resistant to insulin. In addition, lipolysis results in a release of free fatty acid and TG, whereas hypertriglycedemia is potentiated by uremic activation of fatty acid synthase. Hypertriglycedemia and low HDL cholesterol increase the relative risk of progression of CKD. Furthermore, endothelial inflammation and premature atherosclerosis are promoted by hyperhomocysteinemia and oxidation of LDL, both of which are commonly observed in CKD and obesity. Predominance of oxidative stress in both obesity and azotemia stimulate synthesis of angiotensin 11, which in turn increases TGF-B and plasminogen activator inhibitor-1, thereby propagating glomerular fibrosis. Furthermore, local synthesis of angiotensinogen by adipocytes, leptin activation of sympathetic nervous system, and hyperinsulinemia contribute to the development of hypertension in obesity and CKD. In addition, increased renal tubular expression of Na-K-ATPase and a blunted response to natiuretic hormones in obesity promote salt and water retention. Glomerular hyperfiltration from systemic volume load and hypertension results in mesangial cellular proliferation and progressive renal fibrosis. In addition, maternal nutritional deprivation increases the incidence of obesity, hypertension, and diabetes in adulthood. Reduced fetal protein synthesis contributes to oxidative glomerular injury and impairment of renal morphogenesis. Thus, kidneys are poorly equipped to handle physiologic stress that may result from the rapid body growth and programmed metabolic dysfunction later in life. Finally, in order to minimize morbidity of obesity-related kidney disease, preventive strategy must include optimal maternal health care, promotion of healthy nutrition and routine physical exercise, and early detection of CKD. (c) 2006 by the National Kidney Foundation, Inc.
C1 Univ Oklahoma, Hlth Sci Ctr, Dept Pediat, Oklahoma City, OK 73104 USA.
   Childrens Hosp Montefiore, Albert Einstein Coll Med, Dept Pediat Nephrol, Bronx, NY USA.
C3 University of Oklahoma System; University of Oklahoma Health Sciences
   Center; Montefiore Medical Center; Albert Einstein College of Medicine;
   Childrens Hospital at Montefiore; Yeshiva University
RP Bamgbola, O (corresponding author), Univ Oklahoma, Hlth Sci Ctr, Dept Pediat, 940 NE 13th St,2B2309, Oklahoma City, OK 73104 USA.
EM Oluwatoyin-bamgbola@ouhsc.edu
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NR 115
TC 73
Z9 83
U1 0
U2 16
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 1548-5595
EI 1548-5609
J9 ADV CHRONIC KIDNEY D
JI Adv. Chronic Kidney Dis.
PD OCT
PY 2006
VL 13
IS 4
BP 352
EP 364
DI 10.1053/j.ackd.2006.07.010
PG 13
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 096SH
UT WOS:000241396600005
PM 17045221
DA 2025-06-11
ER

PT J
AU Morrone, D
   Picoi, MEL
   Felice, F
   De Martino, A
   Scatena, C
   Spontoni, P
   Naccarato, AG
   Di Stefano, R
   Bortolotti, U
   Dal Monte, M
   Pini, S
   Abelli, M
   Balbarini, A
AF Morrone, Doralisa
   Picoi, Maria Elena Lucia
   Felice, Francesca
   De Martino, Andrea
   Scatena, Cristian
   Spontoni, Paolo
   Naccarato, Antonio Giuseppe
   Di Stefano, Rossella
   Bortolotti, Uberto
   Dal Monte, Massimo
   Pini, Stefano
   Abelli, Marianna
   Balbarini, Alberto
TI Endothelial Progenitor Cells: An Appraisal of Relevant Data from Bench
   to Bedside
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE EPC; ischemic heart disease; progenitor cells
ID AGE-DEPENDENT IMPAIRMENT; MESENCHYMAL STEM-CELLS; CHRONIC HEART-FAILURE;
   BONE-MARROW; MYOCARDIAL-INFARCTION; METABOLIC-SYNDROME; OXIDATIVE
   STRESS; RISK; ANGIOGENESIS; MOBILIZATION
AB The mobilization of endothelial progenitor cells (EPCs) into circulation from bone marrow is well known to be present in several clinical settings, including acute coronary syndrome, heart failure, diabetes and peripheral vascular disease. The aim of this review was to explore the current literature focusing on the great opportunity that EPCs can have in terms of regenerative medicine.
C1 [Morrone, Doralisa; Picoi, Maria Elena Lucia; Felice, Francesca; Spontoni, Paolo; Di Stefano, Rossella; Balbarini, Alberto] Univ Pisa, Cardiovasc Dis Sect, Dept Surg Med & Mol Pathol & Crit Care Med, I-56100 Pisa, Italy.
   [De Martino, Andrea; Bortolotti, Uberto] Univ Pisa, Surg Sect, Dept Surg Med & Mol Pathol & Crit Care Med, I-56100 Pisa, Italy.
   [Scatena, Cristian; Naccarato, Antonio Giuseppe; Di Stefano, Rossella] Univ Pisa, Dept Translat Res & New Technol Med & Surg, I-56126 Pisa, Italy.
   [Dal Monte, Massimo] Univ Pisa, Dept Biol, I-56100 Pisa, Italy.
   [Pini, Stefano; Abelli, Marianna] Univ Pisa, Dept Clin & Expt Med, I-56100 Pisa, Italy.
C3 University of Pisa; University of Pisa; University of Pisa; University
   of Pisa; University of Pisa
RP Morrone, D; Felice, F (corresponding author), Univ Pisa, Cardiovasc Dis Sect, Dept Surg Med & Mol Pathol & Crit Care Med, I-56100 Pisa, Italy.
EM doralisa.morrone@unipi.it; picoielena@tiscali.it;
   francesca.felice@for.unipi.it; and.demartino@libero.it;
   cristian.scatena@unipi.it; paolo.spontoni@gmail.com;
   giuseppe.naccarato@med.unipi.it; rossella.distefano@unipi.it;
   uberto.bortolotti@med.unipi.it; massimo.dalmonte@unipi.it;
   stefano.pini@unipi.it; m.abelli@libero.it; a.balbarini@med.unipi.it
RI Balbarini, Alberto/G-8753-2011; Morrone, Doralisa/AAB-2223-2019; Felice,
   Francesca/C-3882-2009; De Martino, Andrea/M-6415-2019; Dal Monte,
   Massimo/AAA-9275-2022; De Martino, Andrea/H-1268-2019; SCATENA,
   CRISTIAN/K-3525-2018
OI Felice, Francesca/0000-0001-8968-2228; De Martino,
   Andrea/0000-0003-2889-4918; SCATENA, CRISTIAN/0000-0002-4862-0845;
   NACCARATO, ANTONIO GIUSEPPE/0000-0002-8195-9445
FU Fondazione CARISPEZIA
FX This research was funded by Fondazione CARISPEZIA.
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NR 98
TC 14
Z9 15
U1 2
U2 8
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD DEC
PY 2021
VL 22
IS 23
AR 12874
DI 10.3390/ijms222312874
PG 18
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA XW0KN
UT WOS:000735319200001
PM 34884679
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Chen, SJ
   Zhou, L
   Guo, QQ
   Fang, C
   Wang, MK
   Peng, XB
   Yin, JW
   Li, SZ
   Zhu, YL
   Yang, W
   Zhang, Y
   Shan, ZL
   Chen, XY
   Liu, LG
AF Chen, Sijing
   Zhou, Li
   Guo, Qianqian
   Fang, Can
   Wang, Mengke
   Peng, Xiaobo
   Yin, Jiawei
   Li, Shuzhen
   Zhu, Yalun
   Yang, Wei
   Zhang, Yan
   Shan, Zhilei
   Chen, Xiaoyi
   Liu, Liegang
TI Association of plasma chromium with metabolic syndrome among Chinese
   adults: a case-control study
SO NUTRITION JOURNAL
LA English
DT Article
DE Chromium; Metabolic syndrome; High blood glucose; Lipid
ID PICOLINATE SUPPLEMENTATION; YOUNG-ADULTS; GLUCOSE; OBESE; URINE; SERUM;
   DISEASE; STRESS; BLOOD; ZINC
AB Backgroud Chromium has been suggested playing a role in alleviating diabetes, insulin resistance and lipid anomalies, but the effect on metabolic syndrome (MetS) in humans remains controversial. Methods We conducted a matched case-control study in a Chinese population, involving 2141 MetS cases and 2141 healthy controls, which were 1:1 matched by age (+/- 2 years) and sex. Plasma chromium was measured by inductively coupled plasma mass spectrometry. Results Plasma chromium levels were lower in MetS group than in control group (mean: 4.36 mu g/L and 4.66 mu g/L, respectively,P < 0.001), and progressively decreased with the number of MetS components (Pfor trend < 0.001). After adjustment for potential confounding factors, the odds ratios (95% confidence intervals) for MetS across increasing quartiles of plasma chromium levels were 1 (reference), 0.84 (0.67-1.05), 0.76 (0.61-0.95), and 0.62 (0.49-0.78), respectively (Pfor trend < 0.001). For the components of MetS (high waist circumference, high triglycerides and high blood glucose), the odds ratios (95% confidence intervals) of the highest quartiles were 0.77 (0.61-0.95), 0.67 (0.55-0.80), and 0.53 (0.44-0.64), respectively (Pfor trend < 0.05). Conclusions Our results indicated that plasma chromium levels were inversely associated with MetS in Chinese adults. The association may be explained by the relations between plasma chromium levels and high waist circumference, and the triglycerides and blood glucose levels.
C1 [Chen, Sijing; Zhou, Li; Guo, Qianqian; Fang, Can; Wang, Mengke; Peng, Xiaobo; Yin, Jiawei; Li, Shuzhen; Zhu, Yalun; Yang, Wei; Shan, Zhilei; Liu, Liegang] Huazhong Univ Sci & Technol, Sch Publ Hlth, Dept Nutr & Food Hyg, Tongji Med Coll,Hubei Key Lab Food Nutr & Safety, Wuhan 430030, Hubei, Peoples R China.
   [Chen, Sijing; Zhou, Li; Guo, Qianqian; Fang, Can; Wang, Mengke; Peng, Xiaobo; Yin, Jiawei; Li, Shuzhen; Zhu, Yalun; Yang, Wei; Shan, Zhilei; Liu, Liegang] Huazhong Univ Sci & Technol, Sch Publ Hlth, Tongji Med Coll, Minist Educ,Key Lab Environm & Hlth, Wuhan 430030, Hubei, Peoples R China.
   [Zhang, Yan] Hubei Prov Key Lab Yeast Funct, Yichang 443003, Hubei, Peoples R China.
   [Chen, Xiaoyi] Guangzhou Med Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Guangzhou 511436, Peoples R China.
C3 Huazhong University of Science & Technology; Ministry of Education -
   China; Huazhong University of Science & Technology; Guangzhou Medical
   University
RP Liu, LG (corresponding author), Huazhong Univ Sci & Technol, Sch Publ Hlth, Dept Nutr & Food Hyg, Tongji Med Coll,Hubei Key Lab Food Nutr & Safety, Wuhan 430030, Hubei, Peoples R China.; Chen, XY (corresponding author), Guangzhou Med Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Guangzhou 511436, Peoples R China.
EM wwchenxy1@163.com; lgliu@mails.tjmu.edu.cn
RI Shan, Zhilei/S-5189-2019; Chen, Xiaoyi/AAH-6605-2020; guo,
   Qianqian/MGT-0524-2025; wang, mk/JEP-6109-2023; Yin,
   Jiawei/MGV-1674-2025
FU National Natural Science Foundation of China [81803239]; Major
   International (Regional) Joint Research Project [81820108027];
   Fundamental Research Funds for the Central Universities
   [2019kfyXMBZ050]; Angel Nutrition Research Fund
FX This study was supported by the National Natural Science Foundation of
   China (81803239); the Major International (Regional) Joint Research
   Project (81820108027); the Fundamental Research Funds for the Central
   Universities (2019kfyXMBZ050); and the Angel Nutrition Research Fund.
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NR 39
TC 6
Z9 6
U1 4
U2 14
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1475-2891
J9 NUTR J
JI Nutr. J.
PD SEP 23
PY 2020
VL 19
IS 1
AR 107
DI 10.1186/s12937-020-00625-w
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA NV9JO
UT WOS:000574628400001
PM 32967680
OA Green Submitted, gold, Green Published
DA 2025-06-11
ER

PT J
AU Mohammadi, A
   Sadeghnia, HR
   Saberi-Karimian, M
   Safarian, H
   Ferns, GA
   Ghayour-Mobarhan, M
   Sahebkar, A
AF Mohammadi, Akram
   Sadeghnia, Hamid Reza
   Saberi-Karimian, Maryam
   Safarian, Hamideh
   Ferns, Gordon A.
   Ghayour-Mobarhan, Majid
   Sahebkar, Amirhossein
TI Effects of Curcumin on Serum Vitamin E Concentrations in Individuals
   with Metabolic Syndrome
SO PHYTOTHERAPY RESEARCH
LA English
DT Article
DE metabolic syndrome; vitamin E; curcuminoids; turmeric
ID RANDOMIZED CONTROLLED-TRIAL; CLINICAL-PRACTICE; OBESE INDIVIDUALS;
   OXIDATIVE STRESS; METAANALYSIS; TOCOPHEROL; MORTALITY; OSTEOARTHRITIS;
   THERAPY; MEN
AB Vitamin E is an important lipid-soluble antioxidant. The aim of the present study was to investigate the effect of curcumin on serum vitamin E levels in subjects with metabolic syndrome (MetS). A total of 120 subjects aged 18-65 years old with MetS were recruited in this study according to the International Diabetic Federation Criteria. Included subjects were randomized into three groups: subjects receiving lecithinized curcumin (1 g/day equivalent to 200-mg pure curcumin per day) for a period of 6 weeks) n = 40), patients receiving unformulated curcumin (1 g/day) for a period of 6 weeks) n = 40) and a control group receiving placebo for the same period (n = 40). Vitamin E was determined in all patients before and after the intervention using high-performance liquid chromatography method. Results showed that curcumin has no improving effect on serum levels of vitamin E (p > 0.05). There were significant differences between pre-trial and post-trial levels of vitamin E/low-density lipoprotein cholesterol ratio (p < 0.05), vitamin E/high-density lipoprotein cholesterol ratio (p < 0.05), vitamin E/total cholesterol ratio (p < 0.01) and vitamin E/triglyceride ratio (p < 0.05) between the three groups of the study. Results of the present study did not suggest any improving effect of curcumin supplementation on serum vitamin E concentrations in subjects with MetS. Copyright (C) 2017 John Wiley & Sons, Ltd.
C1 [Mohammadi, Akram] Mashhad Univ Med Sci, Sch Med, Dept Modern Sci & Technol, Mashhad, Iran.
   [Sadeghnia, Hamid Reza] Mashhad Univ Med Sci, Sch Med, Dept Pharmacol, Mashhad, Iran.
   [Saberi-Karimian, Maryam] Mashhad Univ Med Sci, Sch Med, Dept Modern Sci & Technol, Student Res Comm, Mashhad, Iran.
   [Safarian, Hamideh] Mashhad Univ Med Sci, Sch Med, Dept Biochem, Mashhad, Iran.
   [Ferns, Gordon A.] Brighton & Sussex Med Sch, Div Med Educ, Brighton BN1 9PH, Sussex, England.
   [Ghayour-Mobarhan, Majid] Mashhad Univ Med Sci, Sch Med, Biochem & Nutr Res Ctr, Mashhad, Iran.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Biotechnol Res Ctr, Mashhad, Iran.
C3 Mashhad University of Medical Sciences; Mashhad University of Medical
   Sciences; Mashhad University of Medical Sciences; Mashhad University of
   Medical Sciences; University of Sussex; University of Brighton; Mashhad
   University of Medical Sciences; Mashhad University of Medical Sciences
RP Ghayour-Mobarhan, M (corresponding author), Mashhad Univ Med Sci, Sch Med, Biochem & Nutr Res Ctr, Mashhad, Iran.; Sahebkar, A (corresponding author), Mashhad Univ Med Sci ences, Sch Med, Dept Biotechnol, Mashhad, Iran.
EM ghayourm@mums.ac.ir; sahebkara@mums.ac.ir
RI Sadeghnia, Hamid/AAA-9820-2019; Ghayour-Mobarhan, Majid/AAY-5963-2020;
   Sahebkar, Amirhossein/B-5124-2018
OI Sadeghnia, Hamid Reza/0000-0002-3228-6897
FU Mashhad University of Medical Sciences (MUMS)
FX We frankly thank all the patients who volunteered to participate in this
   study. Also, the authors would like to thank Mashhad University of
   Medical Sciences (MUMS) for the financial support. A. M., H. R. S., M.
   G.-M. and A. S. contributed in the conception and design of the study,
   acquisition of data, interpretation of data, revising the draft and
   approval of the final version of the manuscript. M. S.-K. contributed in
   the acquisition of data, analysis and interpretation of data, revising
   the draft and approval of the final version of the manuscript. H. S.
   contributed in the acquisition of data. G. A. F. contributed in the
   interpretation of data, revising the draft and approval of the final
   version of the manuscript.
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NR 36
TC 23
Z9 23
U1 0
U2 12
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0951-418X
EI 1099-1573
J9 PHYTOTHER RES
JI Phytother. Res.
PD APR
PY 2017
VL 31
IS 4
BP 657
EP 662
DI 10.1002/ptr.5779
PG 6
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA ER2DM
UT WOS:000398604300011
PM 28198120
OA Bronze
DA 2025-06-11
ER

PT J
AU Vanni, E
   Marengo, A
   Mezzabotta, L
   Bugianesi, E
AF Vanni, Ester
   Marengo, Andrea
   Mezzabotta, Lavinia
   Bugianesi, Elisabetta
TI Systemic Complications of Nonalcoholic Fatty Liver Disease: When the
   Liver Is Not an Innocent Bystander
SO SEMINARS IN LIVER DISEASE
LA English
DT Review
DE nonalcoholic fatty liver disease; metabolic syndrome; cardiovascular
   disease; type 2 diabetes mellitus; colorectal cancer; chronic kidney
   disease
ID CHRONIC KIDNEY-DISEASE; GAMMA-GLUTAMYL-TRANSFERASE; TYPE-2
   DIABETIC-PATIENTS; LEFT-VENTRICULAR FUNCTION; INDEPENDENT RISK-FACTOR;
   CORONARY-HEART-DISEASE; TERM-FOLLOW-UP; INSULIN-RESISTANCE;
   CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME
AB The top three leading causes of death in patients with nonalcoholic fatty liver disease (NAFLD) in descending order are cardiovascular disease, cancer, and liver disease. It is clear now that the increased risk of metabolic and macro-and microvascular complications in NAFLD stems from the associated features of metabolic syndrome. However, NAFLD itself may contribute to the spectrum of risk factors associated with insulin resistance. The primary focus of this review is to summarize the main systemic associations of NAFLD, as well as to discuss the mechanisms that link them to NAFLD. Hepatic lipid accumulation in NAFLD impairs hepatic glucose and lipid metabolism further increasing the risk of type 2 diabetes mellitus and of cardiovascular disease, independently of established risk factors. The incidence, prevalence, and severity of these complications are proportional to the histological severity of liver damage suggesting that NAFLD, but particularly nonalcoholic steatohepatitis, can also contribute to the low-grade inflammatory state through the systemic release of several markers of inflammation, oxidative stress, and of procoagulant factors. The clinical implication of these findings is that patients with NAFLD require a multidisciplinary evaluation, with a major focus on type 2 diabetes mellitus and cardiovascular disease complications and may benefit from more intensive surveillance and early treatment interventions to decrease the risk for cardiovascular and kidney complications.
C1 [Vanni, Ester; Marengo, Andrea; Mezzabotta, Lavinia; Bugianesi, Elisabetta] Univ Torino, AO Citta Salute & Sci Torino, Dept Med Sci, Div Gastrohepatol, I-10126 Turin, Italy.
C3 University of Turin; A.O.U. Citta della Salute e della Scienza di Torino
RP Bugianesi, E (corresponding author), Univ Torino, AO Citta Salute & Sci Torino, Dept Med Sci, Div Gastroenterol & Hepatol, Corso Bramante 88, I-10126 Turin, Italy.
EM elisabetta.bugianesi@unito.it
RI Bugianesi, Elisabetta/K-8008-2016
FU European Union [634413]
FX The authors are members of the EPoS (Elucidating Pathways of
   Steatohepatitis) consortium funded by the Horizon 2020 Framework Program
   of the European Union under Grant Agreement 634413.
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NR 101
TC 65
Z9 67
U1 1
U2 13
PU THIEME MEDICAL PUBL INC
PI NEW YORK
PA 333 SEVENTH AVE, NEW YORK, NY 10001 USA
SN 0272-8087
EI 1098-8971
J9 SEMIN LIVER DIS
JI Semin. Liver Dis.
PD AUG
PY 2015
VL 35
IS 3
BP 236
EP 249
DI 10.1055/s-0035-1562944
PG 14
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA CR6ZX
UT WOS:000361498200004
PM 26378641
DA 2025-06-11
ER

PT J
AU Cruz-Teno, C
   Pérez-Martínez, P
   Delgado-Lista, J
   Yubero-Serrano, EM
   García-Ríos, A
   Marín, C
   Gómez, P
   Jiménez-Gómez, Y
   Camargo, A
   Rodríguez-Cantalejo, F
   Malagón, MM
   Pérez-Jiménez, F
   Roche, HM
   López-Miranda, J
AF Cruz-Teno, Cristina
   Perez-Martinez, Pablo
   Delgado-Lista, Javier
   Yubero-Serrano, Elena M.
   Garcia-Rios, Antonio
   Marin, Carmen
   Gomez, Purificacion
   Jimenez-Gomez, Yolanda
   Camargo, Antonio
   Rodriguez-Cantalejo, Fernando
   Malagon, Maria M.
   Perez-Jimenez, Francisco
   Roche, Helen M.
   Lopez-Miranda, Jose
TI Dietary fat modifies the postprandial inflammatory state in subjects
   with metabolic syndrome: the LIPGENE study
SO MOLECULAR NUTRITION & FOOD RESEARCH
LA English
DT Article
DE Metabolic syndrome; Inflammation; NF-kB; Postprandial state;
   Monounsaturated fatty acids
ID NF-KAPPA-B; BLOOD MONONUCLEAR-CELLS; NECROSIS-FACTOR-ALPHA;
   ADIPOSE-TISSUE; OXIDATIVE STRESS; WEIGHT-LOSS; ACTIVATION; EXPRESSION;
   OBESE; ENDOTHELIUM
AB Scope: Our aim was to investigate whether the inflammatory state associated to metabolic syndrome (MetS) patients is affected by diets with different fat quality and quantity.
   Methods and results: Seventy-five subjects from LIPGENE cohort were included in this feeding trial and randomly assigned to one of four diets: high saturated fatty acids (HSFA); high monounsaturated fatty acids (HMUFA) and two low-fat, high complex carbohydrate (LFHCC) diets, supplemented with long-chain n-3 polyunsaturated fatty acids (LFHCC n-3) or placebo (LFHCC), for 12 weeks each. A postprandial fat challenge, reflecting the intervention dietary fat composition, was conducted post-intervention. The HMUFA diet significantly reduced postprandial nuclear transcription factor-kappaB (NF-kB) activity and the nuclear p65 protein levels relative to fasting values (p < 0.05). Furthermore, we observed a postprandial decrease in this protein with the HMUFA diet compared with the HSFA and LFHCC diets (p < 0.05). The postprandial response of inhibitory molecule from NF-kB mRNA levels increased with the HMUFA diet compared with the HSFA and LFHCC n-3 diets (p < 0.05). Postprandial tumor necrosis factor-alpha and Metalloproteinase 9 mRNA levels were also reduced after the HMUFA diet compared with the HSFA diet (p < 0.05).
   Conclusion: Our results indicate that the long-term consumption of a healthy diet model with HMUFA attenuates the postprandial inflammatory state associated with MetS.
C1 [Cruz-Teno, Cristina; Perez-Martinez, Pablo; Delgado-Lista, Javier; Yubero-Serrano, Elena M.; Garcia-Rios, Antonio; Marin, Carmen; Gomez, Purificacion; Jimenez-Gomez, Yolanda; Camargo, Antonio; Perez-Jimenez, Francisco; Lopez-Miranda, Jose] Univ Cordoba, Lipids & Atherosclerosis Unit, Reina Sofia Univ Hosp, IMIBIC, E-14004 Cordoba, Spain.
   [Cruz-Teno, Cristina; Perez-Martinez, Pablo; Delgado-Lista, Javier; Yubero-Serrano, Elena M.; Garcia-Rios, Antonio; Marin, Carmen; Gomez, Purificacion; Jimenez-Gomez, Yolanda; Camargo, Antonio; Malagon, Maria M.; Perez-Jimenez, Francisco; Lopez-Miranda, Jose] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr CIBEROBN, Cordoba, Spain.
   [Rodriguez-Cantalejo, Fernando] Reina Sofia Univ Hosp, Clin Anal Serv, Cordoba, Spain.
   [Malagon, Maria M.] Univ Cordoba, Dept Cell Biol Physiol & Immunol, Reina Sofia Univ Hosp, IMIBIC, E-14004 Cordoba, Spain.
   [Roche, Helen M.] Univ Coll Dublin, Nutrigenom Res Grp, UCD Conway Inst, Sch Publ Hlth & Populat Sci, Dublin 2, Ireland.
C3 Universidad de Cordoba; CIBER - Centro de Investigacion Biomedica en
   Red; CIBEROBN; Instituto de Salud Carlos III; Hospital Universitario
   Reina Sofia - Cordoba; Universidad de Cordoba; University College Dublin
RP López-Miranda, J (corresponding author), Univ Cordoba, Lipids & Atherosclerosis Unit, Reina Sofia Univ Hosp, IMIBIC, Avda Menendez Pidal S-N, E-14004 Cordoba, Spain.
EM jlopezmir@uco.es
RI Sureda, Antoni/N-9588-2019; Lopez-Miranda, Jose/Y-8306-2019; Marin
   Hinojosa, Carmen/AFO-1294-2022; Yubero-Serrano, Elena/H-4832-2013;
   Delgado-Lista, Javier/KAM-7412-2024; Jimenez, Francisco/AAJ-9559-2021;
   Jimenez-Gomez, Yolanda/Y-3742-2018; Perez Martinez, Pablo/AEL-6176-2022;
   MALAGON, MARIA M/L-5386-2014; Camargo Garcia, Antonio/G-9720-2015
OI Delgado Lista, Francisco Javier/0000-0002-2982-2716; Roche,
   Helen/0000-0002-0628-3318; Yubero-Serrano, Elena M/0000-0002-2733-5359;
   Lopez-Miranda, Jose/0000-0002-8844-0718; Perez-Jimenez,
   Francisco/0000-0001-7499-7681; Jimenez-Gomez,
   Yolanda/0000-0002-1607-2717; Perez Martinez, Pablo/0000-0001-7716-8117;
   MALAGON, MARIA M/0000-0002-2419-2727; Camargo Garcia,
   Antonio/0000-0002-0415-4184; Perez Jimenez,
   Francisco/0000-0001-9808-1280
FU European community (LIPGENE European Integrated Proyect) [505944];
   Consejeria de Salud [07/43, PI-0193/2009]; Consejeria de Innovacion;
   Proyecto de investigacion de excelencia; Junta de Andalucia
   [P06-CTS-01425]; Spanish Ministry of Education and Science
   [AGL2006-01979/ALI, AGL2009-12270]; Spanish Ministry of Health
   [CB06/03/0047]
FX This study was supported in part by research grants from the European
   community (LIPGENE European Integrated Proyect-505944), Consejeria de
   Salud (07/43, PI-0193/2009), Consejeria de Innovacion, Proyecto de
   investigacion de excelencia, Junta de Andalucia (P06-CTS-01425), the
   Spanish Ministry of Education and Science (AGL2006-01979/ALI and
   AGL2009-12270) and the Spanish Ministry of Health (CB06/03/0047 (CIBER
   Fisiopatologia de la Obesidad y Nutricion is an initiative of ISCIII)).
   Fondo Europeo de Desarrollo Regional (FEDER). We thank to M Jose
   Gomez-Luna for technical support.
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NR 46
TC 76
Z9 79
U1 0
U2 19
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1613-4125
EI 1613-4133
J9 MOL NUTR FOOD RES
JI Mol. Nutr. Food Res.
PD JUN
PY 2012
VL 56
IS 6
BP 854
EP 865
DI 10.1002/mnfr.201200096
PG 12
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA 959OU
UT WOS:000305323100003
PM 22707261
DA 2025-06-11
ER

PT J
AU Ye, L
   Hu, P
   Feng, LP
   Huang, LL
   Wang, Y
   Yan, X
   Xiong, J
   Xia, HL
AF Ye, Lei
   Hu, Pan
   Feng, Li-Ping
   Huang, Li-Lu
   Wang, Yi
   Yan, Xin
   Xiong, Jing
   Xia, Hou-Lin
TI Protective Effects of Ferulic Acid on Metabolic Syndrome: A
   Comprehensive Review
SO MOLECULES
LA English
DT Review
DE ferulic acid; metabolic syndrome; diabetes; hyperlipidemia;
   hypertension; obesity
ID HIGH-FAT-DIET; ENDOTHELIUM-DEPENDENT VASODILATION; COMMERCIAL
   HYPOGLYCEMIC DRUGS; HIGH BLOOD-PRESSURE; OXIDATIVE STRESS; ANTIOXIDANT
   ACTIVITY; INSULIN-RESISTANCE; RAT MODEL; IN-VITRO; SUPPRESSES
   ADIPOGENESIS
AB Metabolic syndrome (MetS) is a complex disease in which protein, fat, carbohydrates and other substances are metabolized in a disorderly way. Ferulic acid (FA) is a phenolic acid found in many vegetables, fruits, cereals and Chinese herbs that has a strong effect on ameliorating MetS. However, no review has summarized the mechanisms of FA in treating MetS. This review collected articles related to the effects of FA on ameliorating the common symptoms of MetS, such as diabetes, hyperlipidemia, hypertension and obesity, from different sources involving Web of Science, PubMed and Google Scholar, etc. This review summarizes the potential mechanisms of FA in improving various metabolic disorders according to the collected articles. FA ameliorates diabetes via the inhibition of the expressions of PEPCK, G6Pase and GP, the upregulation of the expressions of GK and GS, and the activation of the PI3K/Akt/GLUT4 signaling pathway. The decrease of blood pressure is related to the endothelial function of the aortas and RAAS. The improvement of the lipid spectrum is mediated via the suppression of the HMG-Co A reductase, by promoting the ACSL1 expression and by the regulation of the factors associated with lipid metabolism. Furthermore, FA inhibits obesity by upregulating the MEK/ERK pathway, the MAPK pathway and the AMPK signaling pathway and by inhibiting SREBP-1 expression. This review can be helpful for the development of FA as an appreciable agent for MetS treatment.
C1 [Ye, Lei; Feng, Li-Ping; Huang, Li-Lu; Wang, Yi; Xia, Hou-Lin] Chengdu Univ Tradit Chinese Med, Sch Pharm, Chengdu 611137, Peoples R China.
   [Hu, Pan; Yan, Xin; Xiong, Jing] Chengdu Inst Chinese Herbal Med, Chengdu 610016, Peoples R China.
C3 Chengdu University of Traditional Chinese Medicine
RP Xia, HL (corresponding author), Chengdu Univ Tradit Chinese Med, Sch Pharm, Chengdu 611137, Peoples R China.; Hu, P (corresponding author), Chengdu Inst Chinese Herbal Med, Chengdu 610016, Peoples R China.
EM hupan123@126.com; xhl64@163.com
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NR 151
TC 30
Z9 30
U1 4
U2 60
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1420-3049
J9 MOLECULES
JI Molecules
PD JAN
PY 2023
VL 28
IS 1
AR 281
DI 10.3390/molecules28010281
PG 18
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 7P8OE
UT WOS:000908958200001
PM 36615475
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Sánchez-Solís, CN
   Hernández-Fragoso, H
   Aburto-Luna, V
   Olivier, CB
   Diaz, A
   Brambila, E
   Treviño, S
AF Neftaly Sanchez-Solis, Cristhian
   Hernandez-Fragoso, Hugo
   Aburto-Luna, Violeta
   Barbier Olivier, Christophe
   Diaz, Alfonso
   Brambila, Eduardo
   Trevino, Samuel
TI Kidney Adaptations Prevent Loss of Trace Elements in Wistar Rats with
   Early Metabolic Syndrome
SO BIOLOGICAL TRACE ELEMENT RESEARCH
LA English
DT Article
DE Metabolic syndrome; Chronic kidney disease; Hypercaloric diet; Trace
   elements; Micronutrients
ID INSULIN-RESISTANCE; DIABETES-MELLITUS; OXIDATIVE STRESS; PROXIMAL
   TUBULE; NONDIABETIC SUBJECTS; DOUBLE-BLIND; DISEASE; INJURY;
   ADIPONECTIN; ASSOCIATION
AB Metabolic syndrome (MetS) represents a cluster of related metabolic abnormalities, including central obesity, hypertension, dyslipidemia, hyperglycemia, and insulin resistance. These metabolic derangements present significant risk factors for chronic kidney disease that carries to loss of essential micronutrients, which accelerates comorbidity apparition. The work aimed was to evaluate the trace element homeostasis regarding morphological adaptations and renal function in MetS early-onset. Fifty male Wistar rats were divided into two groups: (a) control group and (b) hypercaloric diet group that developed MetS early-onset after 3 months. Classical zoometric parameters do not show changes; however, biochemical modifications were observed such as hyperglycemia, protein glycation, insulin resistance, dyslipidemia, hyperinsulinemia, and hypoadiponectinemia. MetS early-onset group observed renal structural modifications, but no functional changes. The structural modifications observed were minimal glomerular injury, glomerular basement membrane thickening, as well as mesangial and tubular cells that showed growth and proliferation. In serum and kidney (cortex and medulla), the concentrations of Zn, Fe, Cr, Mg, Mn, Cu, Co, and Ni were no differences between the experimental groups, but excretory fractions of these were lower in the hypercaloric diet group. In conclusion, MetS early-onset coexist renal structural modification and a hyperreabsorptive activity of essential trace elements that avoid its loss; thus, the excretory fraction of oligo-elements could be used a biomarker of early renal injury caused by metabolic diseases in the clinical practice.
C1 [Neftaly Sanchez-Solis, Cristhian; Hernandez-Fragoso, Hugo; Aburto-Luna, Violeta; Brambila, Eduardo; Trevino, Samuel] Benemerita Univ Autonoma Puebla, Fac Ciencias Quim, Lab Invest Quim Clin, Puebla, Mexico.
   [Barbier Olivier, Christophe] Inst Politecn Nacl, Dept Toxicol, Ctr Invest & Estudios Avanzados, Mexico City, DF, Mexico.
   [Diaz, Alfonso] Benemerita Univ Autonoma Puebla, Fac Ciencias Quim, Dept Farm, Puebla, Mexico.
   [Trevino, Samuel] Univ Autonoma Puebla, Fac Ciencias Quim, Dept Quim Clin, Lab Invest Quim Clin, 14 Sur FCQ1,Ciudad Univ, Puebla 72560, Mexico.
C3 Benemerita Universidad Autonoma de Puebla; Instituto Politecnico
   Nacional - Mexico; CINVESTAV - Centro de Investigacion y de Estudios
   Avanzados del Instituto Politecnico Nacional; Benemerita Universidad
   Autonoma de Puebla; Benemerita Universidad Autonoma de Puebla
RP Treviño, S (corresponding author), Benemerita Univ Autonoma Puebla, Fac Ciencias Quim, Lab Invest Quim Clin, Puebla, Mexico.; Treviño, S (corresponding author), Univ Autonoma Puebla, Fac Ciencias Quim, Dept Quim Clin, Lab Invest Quim Clin, 14 Sur FCQ1,Ciudad Univ, Puebla 72560, Mexico.
EM samuel_trevino@hotmail.com
RI Barbier, Olivier/AFU-7274-2022
OI Barbier, Olivier Christophe/0000-0002-0378-3675; Diaz,
   Alfonso/0000-0003-4092-6636; Sanchez Solis, Cristhian
   Neftaly/0000-0001-9184-2278; , Hugo/0000-0001-5422-8367; Brambila,
   Eduardo/0000-0003-0377-0943
FU Vicerrectoria de Investigacion y Posgrado [VIEP] [TRMS-NAT19-1, 000536];
   "Sistema Nacional de Investigadores" of Mexico [000536]; CONACyT
   [000536]
FX The Vicerrectoria de Investigacion y Posgrado [VIEP; TRMS-NAT19-1]
   through Ygnacio Martinez Laguna, CONACyT and the "Sistema Nacional de
   Investigadores" of Mexico provided financial support for this research
   project [CNSS, 000536].
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NR 97
TC 4
Z9 4
U1 1
U2 6
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0163-4984
EI 1559-0720
J9 BIOL TRACE ELEM RES
JI Biol. Trace Elem. Res.
PD MAY
PY 2021
VL 199
IS 5
BP 1941
EP 1953
DI 10.1007/s12011-020-02317-2
EA AUG 2020
PG 13
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA RC0CV
UT WOS:000559276900003
PM 32789645
DA 2025-06-11
ER

PT J
AU Sureda, A
   Bibiloni, MD
   Martorell, M
   Buil-Cosiales, P
   Marti, A
   Pons, A
   Tur, JA
   Martinez-Gonzalez, MA
AF Sureda, Antoni
   del Mar Bibiloni, Maria
   Martorell, Miquel
   Buil-Cosiales, Pilar
   Marti, Amelia
   Pons, Antoni
   Tur, Josep A.
   Angel Martinez-Gonzalez, Miguel
CA PREDIMED Study Investigators
TI Mediterranean diets supplemented with virgin olive oil and nuts enhance
   plasmatic antioxidant capabilities and decrease xanthine oxidase
   activity in people with metabolic syndrome: The PREDIMED study
SO MOLECULAR NUTRITION & FOOD RESEARCH
LA English
DT Article
DE Antioxidant enzymes; Nitrosative damage; Oxidative damage; PREDIMED;
   Prooxidant markers
ID SPONTANEOUSLY HYPERTENSIVE-RATS; SUPEROXIDE DISMUTASE ACTIVITY;
   OXIDATIVE STRESS; NITRIC-OXIDE; BLOOD-PRESSURE; FOLLOW-UP;
   CARDIOVASCULAR-DISEASE; LIPOPROTEIN OXIDATION; ADHERENCE; HEALTH
AB Scope: This study assessed plasmatic antioxidant capabilities and xanthine oxidase (XOX) activity in metabolic syndrome patients after 5 years intervention with Mediterranean diet (Me-Diet) supplemented with extra-virgin olive oil or with nuts or with low-fat diet (the PREDIMED [PREvencion con Dieta MEDiterranea] study).
   Methods and results: Seventy-five participants were randomly selected. Daily energy and nutrient intake were assessed with a validated 137-item food frequency questionnaire, and adherence to the MeDiet was assessed using a 14-item questionnaire. Catalase, superoxide dismutase (SOD), myeloperoxidase, XOX activities and protein levels, and protein carbonyl derivatives, nitrotyrosine, nitrite and nitrate levels were determined in overnight fasting venous blood samples. The plasma activity and protein levels of SOD and catalase were significantly higher and XOX activity was lower in MeDiet supplemented with extra-virgin olive oil and MeDiet supplemented with nuts than in the control group. Participants in both MeDiet groups showed higher plasma nitrate levels than in the control group. Adherence to the MeDiet showed a positive correlation with SOD and catalase plasma antioxidant activities.
   Conclusion: A MeDiet enriched with either virgin olive oil or nuts enhances the plasma antioxidant capabilities and decreases XOX activity in patients with the metabolic syndrome but we did not observe changes in myeloperoxidase or markers of oxidative damage.
C1 [Sureda, Antoni; del Mar Bibiloni, Maria; Martorell, Miquel; Pons, Antoni; Tur, Josep A.] Univ Balearic Isl, Res Grp Community Nutr & Oxidat Stress, Palma De Mallorca, Spain.
   [Sureda, Antoni; del Mar Bibiloni, Maria; Buil-Cosiales, Pilar; Marti, Amelia; Pons, Antoni; Tur, Josep A.; Angel Martinez-Gonzalez, Miguel] Inst Salud Carlos III, RD 06 0045, Madrid, Spain.
   [Sureda, Antoni; del Mar Bibiloni, Maria; Buil-Cosiales, Pilar; Marti, Amelia; Pons, Antoni; Tur, Josep A.; Angel Martinez-Gonzalez, Miguel] Inst Salud Carlos III, CIBEROBN Fisiopatol Obesidad & Nutr, Madrid, Spain.
   [Martorell, Miquel] Univ Concepcion, Fac Farm, Dept Nutr & Dietet, Concepcion, Chile.
   [Buil-Cosiales, Pilar; Marti, Amelia; Angel Martinez-Gonzalez, Miguel] Univ Navarra IDISNA, Dept Prevent Med & Publ Hlth, Sch Med, Pamplona, Spain.
C3 Universitat de les Illes Balears; Instituto de Salud Carlos III;
   Instituto de Salud Carlos III; CIBER - Centro de Investigacion Biomedica
   en Red; CIBEROBN; Universidad de Concepcion; University of Navarra
RP Tur, JA (corresponding author), Univ Balearic Isl, Res Grp Community Nutr & Oxidat Stress, Palma De Mallorca, Spain.; Tur, JA (corresponding author), Inst Salud Carlos III, RD 06 0045, Madrid, Spain.; Tur, JA (corresponding author), Inst Salud Carlos III, CIBEROBN Fisiopatol Obesidad & Nutr, Madrid, Spain.
EM pep.tur@uib.es
RI Tur, Josep/AAE-5748-2020; Martinez-Gonzalez, Miguel/AAE-7669-2019;
   Sureda, Antoni/N-9588-2019; del Mar Bibiloni, Maria/M-3123-2014; Pons,
   Antoni/L-4844-2014; Martorell, Miquel/H-8490-2014; Marti del Moral,
   Amelia/H-1192-2017
OI Buil-Cosiales, Pilar/0000-0002-8586-577X; Pons,
   Antoni/0000-0003-2447-3868; Bibiloni Esteva, Maria del
   Mar/0000-0001-8926-9206; Martorell, Miquel/0000-0003-3183-7623;
   Martinez-Gonzalez, Miguel A./0000-0002-3917-9808; Marti del Moral,
   Amelia/0000-0001-9832-7981; , Antoni/0000-0001-8656-6838
FU Spanish Ministry of Health and Consumption Affairs [11/01791, 14/00636,
   Red Predimed-RETIC RD06/0045/1004, CIBEROBN CB12/03/30038]; BI Govnt.
   [35/2011]; EU FEDER funds
FX This study was funded by the Spanish Ministry of Health and Consumption
   Affairs (Projects 11/01791, 14/00636, Red Predimed-RETIC RD06/0045/1004,
   and CIBEROBN CB12/03/30038), Grant of support to research groups no.
   35/2011 (BI Govnt.), and EU FEDER funds.
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NR 63
TC 51
Z9 52
U1 0
U2 14
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1613-4125
EI 1613-4133
J9 MOL NUTR FOOD RES
JI Mol. Nutr. Food Res.
PD DEC
PY 2016
VL 60
IS 12
BP 2654
EP 2664
DI 10.1002/mnfr.201600450
PG 11
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA EJ3ZV
UT WOS:000393156600012
PM 27600061
DA 2025-06-11
ER

PT J
AU Vigil, L
   Condés, E
   Varela, M
   Rodriguez, C
   Colas, A
   Vargas, B
   Lopez, M
   Cirugeda, E
AF Vigil, Luis
   Condes, Emilia
   Varela, Manuel
   Rodriguez, Carmen
   Colas, Ana
   Vargas, Borja
   Lopez, Manuel
   Cirugeda, Eva
TI Glucose series complexity in hypertensive patients
SO JOURNAL OF THE AMERICAN SOCIETY OF HYPERTENSION
LA English
DT Article
DE Detrended fluctuation analysis; diabetes mellitus; metabolic syndrome;
   mean amplitude of glycemic excursions
ID APPROXIMATE ENTROPY; METABOLIC SYNDROME; OXIDATIVE STRESS; GLYCEMIC
   PROFILE; HEART-RATE; DYNAMICS; FLUCTUATIONS; VARIABILITY
AB Nonlinear methods have been applied to the analysis of biological signals. Complexity analysis of glucose time series may be a useful tool for the study of the initial phases of glucoregulatory dysfunction. This observational, cross-sectional study was performed in patients with essential hypertension. Glucose complexity was measured with detrended fluctuation analysis (DFA), and glucose variability was measured by the mean amplitudes of glycemic excursion (MAGE). We included 91 patients with a mean age of 59 10 years. We found significant correlations for the number of metabolic syndrome (MS)-defining criteria with DFA (r = 0.233, P =.026) and MAGE (r = 0.396, P <.0001). DFA differed significantly between patients who complied with MS and those who did not (1.44 vs. 1.39, P =.018). The MAGE (f = 5.3, P =.006), diastolic blood pressures (f = 4.1, P =.018), and homeostasis model assessment indices (f = 4.2, P =.018) differed between the DFA tertiles. Multivariate analysis revealed that the only independent determinants of the DFA values were MAGE (beta coefficient = 0.002, 95% confidence interval: 0.001-0.004, P = .001) and abdominal circumference (beta coefficient = 0.002, 95% confidence interval: 0.000015-0.004, P = .048). In our population, DFA was associated with MS and a number of MS criteria. Complexity analysis seemed to be capable of detecting differences in variables that are arguably related to the risk of the development of type 2 diabetes. (C) 2014 American Society of Hypertension. All rights reserved.
C1 [Vigil, Luis; Varela, Manuel; Rodriguez, Carmen; Colas, Ana; Vargas, Borja; Lopez, Manuel] Univ Hosp Mostoles, Dept Internal Med, Madrid 28935, Spain.
   [Condes, Emilia] Univ Europea Madrid, Madrid, Spain.
   [Cirugeda, Eva] Univ Politecn Valencia, Comp Sci Dept DISCA, Alcoy, Spain.
C3 Hospital Universitario de Mostoles; European University of Madrid;
   Universitat Politecnica de Valencia
RP Vigil, L (corresponding author), Univ Hosp Mostoles, Dept Internal Med, Hypertens Unit, C Rio Jucar S-N, Madrid 28935, Spain.
EM lvigil.hmtl@salud.madrid.org
RI Vargas, Borja/K-4297-2018; Cirugeda, Eva/AAH-2096-2019; Colás,
   Ana/AFP-2489-2022; Lopez Jimenez, Manuel/C-1649-2016; Condes,
   Emilia/E-3582-2016; Vigil, Luis/C-6875-2016; Rodriguez-Castro,
   Carmen/C-5442-2016
OI Lopez Jimenez, Manuel/0000-0002-5205-1630; Vargas,
   Borja/0000-0002-5553-8372; Condes, Emilia/0000-0001-6756-3316; Colas
   Herrera, Ana/0000-0003-2784-4150; Vigil, Luis/0000-0001-7484-2911;
   Cirugeda Roldan, Eva M./0000-0002-0623-3652; Rodriguez-Castro,
   Carmen/0000-0003-4970-9187
FU Fondo de Investigacion Sanitaria, Ministerio de Sanidad y Consumo, Spain
   [11/00811]
FX Grant Support: Supported by Grant 11/00811 of the Fondo de Investigacion
   Sanitaria, Ministerio de Sanidad y Consumo, Spain.
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NR 25
TC 5
Z9 5
U1 0
U2 9
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1933-1711
EI 1878-7436
J9 J AM SOC HYPERTENS
JI J. Am. Soc. Hypertens.
PD SEP
PY 2014
VL 8
IS 9
BP 630
EP 636
DI 10.1016/j.jash.2014.05.008
PG 7
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA AQ1PK
UT WOS:000342553100004
PM 25065679
DA 2025-06-11
ER

PT J
AU Mok, CC
AF Mok, Chi Chiu
TI Metabolic syndrome and systemic lupus erythematosus: the connection
SO EXPERT REVIEW OF CLINICAL IMMUNOLOGY
LA English
DT Review
DE Obesity; cardiovascular; lupus; metabolic syndrome; adipokine
ID INCREASED ARTERIAL STIFFNESS; INSULIN-RESISTANCE; CARDIOVASCULAR RISK;
   ASYMMETRIC DIMETHYLARGININE; RHEUMATOID-ARTHRITIS; OXIDATIVE STRESS;
   LEPTIN LEVELS; ORGAN DAMAGE; ALL-CAUSE; ANTIPHOSPHOLIPID SYNDROME
AB Introduction: The metabolic syndrome (MetS) is now recognized as a chronic proinflammatory and prothrombotic state that aggravates insulin resistance, oxidative injury, and cardiovascular risk. MetS is more prevalent in patients with systemic lupus erythematosus (SLE), a prototype of systemic autoimmune disease associated with premature atherosclerosis that cannot be accounted by traditional vascular risk factors alone. Dysregulation of the cytokines and adipokines is a common feature in both SLE and MetS, suggesting a complex relationship among autoimmunity, obesity, inflammation, and atherosclerosis.Areas covered: This review summarizes the prevalence of MetS and its effect on cardiovascular outcome and organ damage in patients with SLE. The pathophysiology of MetS and its relevance to SLE is also briefly discussed.Expert opinion: Imbalance of adipokine production in MetS contributes to inflammation and atherosclerosis. MetS predisposes SLE patients to new cardiovascular events and vascular mortality, as well as the development of chronic kidney disease and diabetes mellitus. However, conflicting results have been reported in the literature regarding the levels of the proinflammatory leptin and anti-inflammatory adiponectin, and their relationship with disease activity in SLE patients. While lifestyle modifications and targeting dyslipidemia, hypertension and diabetes mellitus is essential, there is little information on the efficacy and safety of metformin and hydroxychloroquine in alleviating insulin resistance in SLE or MetS. Further research on adipokines in SLE and the role of anti-obesity medications and probiotics in MetS is necessary.
C1 [Mok, Chi Chiu] Tuen Mun Hosp, Dept Med, Hong Kong, Peoples R China.
C3 Tuen Mun Hospital
RP Mok, CC (corresponding author), Tuen Mun Hosp, Div Rheumatol, Dept Med, Tsing Chung Koon Rd, Hong Kong, Peoples R China.
EM ccmok2005@yahoo.com
OI Mok, CC/0000-0003-3696-1228
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NR 142
TC 45
Z9 46
U1 1
U2 24
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1744-666X
EI 1744-8409
J9 EXPERT REV CLIN IMMU
JI Expert Rev. Clin. Immunol.
PD JUL 3
PY 2019
VL 15
IS 7
BP 765
EP 775
DI 10.1080/1744666X.2019.1620601
PG 11
WC Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology
GA IG3CH
UT WOS:000473677600008
PM 31094570
DA 2025-06-11
ER

PT J
AU Park, SB
   Kang, JY
   Kim, JM
   Park, SK
   Yoo, SK
   Lee, U
   Kim, DO
   Heo, HJ
AF Park, Su Bin
   Kang, Jin Yong
   Kim, Jong Min
   Park, Seon Kyeong
   Yoo, Seul Ki
   Lee, Uk
   Kim, Dae-Ok
   Heo, Ho Jin
TI Effect of Aruncus dioicus var. kamtschaticus Extract on
   Neurodegeneration Improvement: Ameliorating Role in Cognitive Disorder
   Caused by High-Fat Diet Induced Obesity
SO NUTRIENTS
LA English
DT Article
DE neurodegeneration; metabolic syndrome; insulin resistance; high-fat
   diet; Aruncus dioicus var; kamtschaticus
ID INSULIN-RESISTANCE; TNF-ALPHA; DYSFUNCTION; ACTIVATION; INFLAMMATION;
   SENSITIVITY; DISEASE; BRAIN
AB This study was performed to estimate the possibility of using an ethyl acetate fraction from Aruncus dioicus var. kamtschaticus (EFAD) on metabolic syndrome that is induced by a high-fat diet (HFD). It was demonstrated that EFAD suppresses lipid accumulation and improves insulin resistance (IR) caused by Tumor necrosis factor alpha (TNF-alpha) in in-vitro experiments using the 3T3-L1 cell. In in-vivo tests, C57BL/6 mice were fed EFAD at 20 and 40 mg/kg body weight (BW) for four weeks after the mice were fed HFD for 15 weeks to induce obesity. EFAD significantly suppressed the elevation of BW and improved impaired glucose tolerance in obese mice. Additionally, this study showed that EFAD has an ameliorating effect on obesity-induced cognitive disorder with behavioral tests. The effect of EFAD on peripheral-IR improvement was confirmed by serum analysis and western blotting in peripheral tissues. Additionally, EFAD showed an ameliorating effect on HFD-induced oxidative stress, impaired cholinergic system and mitochondrial dysfunction, which are interrelated symptoms of neurodegeneration, such as Alzheimer's disease and central nervous system (CNS)-IR in brain tissue. Furthermore, we confirmed that EFAD improves CNS-IR by confirming the IR-related factors in brain tissue. Consequently, this study suggests the possibility of using EFAD for the prevention of neurodegeneration by improving metabolic syndrome that is caused by HFD.
C1 [Park, Su Bin; Kang, Jin Yong; Kim, Jong Min; Park, Seon Kyeong; Yoo, Seul Ki; Heo, Ho Jin] Gyeongsang Natl Univ, Div Appl Life Sci BK21 Plus, Inst Agr & Life Sci, Jinju 52828, South Korea.
   [Lee, Uk] Natl Inst Forest Sci, Div Special Forest Prod, Suwon 16631, South Korea.
   [Kim, Dae-Ok] Kyung Hee Univ, Dept Food Sci & Biotechnol, Yongin 17104, South Korea.
C3 Gyeongsang National University; Korea Forest Research Institute (KFRI);
   National Institute of Forest Science (NIFOS), Republic of South Korea;
   Kyung Hee University
RP Heo, HJ (corresponding author), Gyeongsang Natl Univ, Div Appl Life Sci BK21 Plus, Inst Agr & Life Sci, Jinju 52828, South Korea.
EM tbsk5670@naver.com; kangjy2132@naver.com; myrock201@naver.com;
   tjsrud2015@naver.com; ysyk9412@naver.com; rich26@korea.kr;
   dokim05@khu.ac.kr; hjher@gnu.ac.kr
RI Kim, Jinsoo/G-6348-2012; Park, Su-Bin/IVH-9442-2023; Kim,
   Dae-Ok/AAK-7252-2020
OI Kim, Dae-Ok/0000-0001-9262-1354; Kim, Jong Min/0000-0001-7926-4778; heo,
   ho jin/0000-0002-3560-2007
FU Korea Forest Service (Korea Forestry Promotion Institute)
   [2017028A00-1819-BA01]
FX This research was funded by Korea Forest Service (Korea Forestry
   Promotion Institute), grant number Project No. 2017028A00-1819-BA01.
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NR 34
TC 10
Z9 10
U1 1
U2 11
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JUN
PY 2019
VL 11
IS 6
AR 1319
DI 10.3390/nu11061319
PG 21
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA II1AJ
UT WOS:000474936700125
PM 31212845
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Ueba, T
   Nomura, S
   Nishikawa, T
   Kajiwara, M
   Yamashita, K
AF Ueba, Tetsuya
   Nomura, Shosaku
   Nishikawa, Tomofumi
   Kajiwara, Motohiro
   Yamashita, Kohsuke
TI Circulating oxidized LDL, measured with FOH1a/DLH3 antibody, is
   associated with metabolic syndrome and the coronary heart disease risk
   score in healthy Japanese
SO ATHEROSCLEROSIS
LA English
DT Article
DE Atherosclerosis; oxLDL; Metabolic syndrome; Coronary heart disease risk
   score
ID LOW-DENSITY-LIPOPROTEIN; C-REACTIVE PROTEIN; MIDDLE-AGED MEN; OXIDATIVE
   STRESS; INDEPENDENT PREDICTOR; MARKER
AB Background and purpose: The objective of this study was to clarify the relationship between circulating oxidized LDL (oxLDL) and metabolic syndrome (MS) and the coronary heart disease (CHD) risk score.
   Methods: We conducted a cross-sectional study of healthy volunteers who had no signs, symptoms or history of cardiovascular or cerebrovascular disease and took no medications. We studied 382 Japanese volunteers, 190 men and 192 women (median age 41 and 38 years, respectively). We used an ELISA kit and a monoclonal oxLDL antibody, FOH1a/DLH3, to measure circulating oxLDL.
   Results: The odds ratio (OR) for elevated oxLDL in individuals with MS compared to those without MS, adjusted for age and sex, was 1.94 (range 1.00-3.78). In individuals with a predicted Framingham 10-year risk for CHD>5% (corresponding with the highest quartile), compared to those with a predicted 10-year risk <5%, the OR, adjusted for age, sex, smoking, and LDL cholesterol, was 2.51 (1.17-5.36). The age-, sex-, smoking- and LDL cholesterol-adjusted OR for a 10-year CHD risk score > 5% was 1.03 (1.01-1.04) for LDL cholesterol and 11.7 (4.69-29.0) for smoking.
   Conclusions: Elevated oxLDL is associated with the presence of MS and the CHID risk score in healthy people. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
C1 [Ueba, Tetsuya; Nishikawa, Tomofumi; Kajiwara, Motohiro; Yamashita, Kohsuke] Kishiwada City Hosp, Dept Neurosurg, Kishiwada, Osaka 5968501, Japan.
   [Nomura, Shosaku] Kishiwada City Hosp, Dept Hematol, Kishiwada, Osaka 5968501, Japan.
RP Ueba, T (corresponding author), Kishiwada City Hosp, Dept Neurosurg, 1000 Gakuharachou, Kishiwada, Osaka 5968501, Japan.
EM tueba@kuhp.kyoto-u.ac.jp
RI Ueba, Tetsuya/AFL-6434-2022
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NR 30
TC 17
Z9 17
U1 0
U2 1
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0021-9150
EI 1879-1484
J9 ATHEROSCLEROSIS
JI Atherosclerosis
PD MAR
PY 2009
VL 203
IS 1
BP 243
EP 248
DI 10.1016/j.atherosclerosis.2008.05.048
PG 6
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 423QL
UT WOS:000264510700037
PM 18635189
DA 2025-06-11
ER

PT J
AU Rickard, IJ
   Lummaa, V
AF Rickard, Ian J.
   Lummaa, Virpi
TI The predictive adaptive response and metabolic syndrome: challenges for
   the hypothesis
SO TRENDS IN ENDOCRINOLOGY AND METABOLISM
LA English
DT Review
ID CORONARY-HEART-DISEASE; LIFE-HISTORY; PRENATAL EXPOSURE; IN-UTERO;
   GROWTH; EVOLUTION; FETAL; MAINTENANCE; CHILDHOOD; MORTALITY
AB In humans and other mammals, maternal undernutrition or stress during gestation results in small offspring with permanently altered metabolism and tissue composition. It has been suggested that such responses might exist because in utero conditions provide a reliable 'prediction' of the environmental conditions that foetuses will eventually be exposed to during adulthood. Thus, some developmental responses to the early environment might improve an individual's evolutionary success in a similar future environment.
C1 Univ Sheffield, Dept Anim & Plant Sci, Sheffield S10 2TN, S Yorkshire, England.
C3 University of Sheffield
RP Rickard, IJ (corresponding author), Univ Sheffield, Dept Anim & Plant Sci, Sheffield S10 2TN, S Yorkshire, England.
EM i.rickard@sheffield.ac.uk
RI Lummaa, Virpi/AHB-0181-2022
OI Rickard, Ian/0000-0003-0762-1689
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NR 48
TC 70
Z9 83
U1 0
U2 28
PU ELSEVIER SCIENCE LONDON
PI LONDON
PA 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND
SN 1043-2760
EI 1879-3061
J9 TRENDS ENDOCRIN MET
JI Trends Endocrinol. Metab.
PD APR
PY 2007
VL 18
IS 3
BP 94
EP 99
DI 10.1016/j.tem.2007.02.004
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 159AT
UT WOS:000245838500004
PM 17320410
DA 2025-06-11
ER

PT J
AU Matsubara, T
   Naruse, K
   Arakawa, T
   Nakao, M
   Yokoi, K
   Oguri, M
   Marui, N
   Amano, T
   Ichimiya, S
   Ohashi, T
   Imai, K
   Sakai, S
   Sugiyama, S
   Ishii, H
   Murohara, T
AF Matsubara, Tatsuaki
   Naruse, Keiko
   Arakawa, Takemi
   Nakao, Masahide
   Yokoi, Kiyoshi
   Oguri, Mitsutoshi
   Marui, Nobuyuki
   Amano, Tetsuya
   Ichimiya, Satoshi
   Ohashi, Taiki
   Imai, Kenji
   Sakai, Shinichi
   Sugiyama, Satoru
   Ishii, Hideki
   Murohara, Toyoaki
TI Impact of pitavastatin on high-sensitivity C-reactive protein and
   adiponectin in hypercholesterolemic patients with the metabolic
   syndrome: The PREMIUM Study
SO JOURNAL OF CARDIOLOGY
LA English
DT Article
DE Metabolic syndrome; Pitavastatin; Inflammation; Adiponectin;
   High-density lipoprotein cholesterol
ID HIGH-DENSITY-LIPOPROTEIN; CORONARY-ARTERY-DISEASE; JAPANESE PATIENTS;
   CARDIOVASCULAR-DISEASE; INSULIN-RESISTANCE; DIABETES-MELLITUS; OXIDATIVE
   STRESS; EVENTS; MEN; ATHEROSCLEROSIS
AB Background: Inflammatory reactions and oxidative stress, which are important in progression of atherosclerosis, are reported to be increased in individuals with metabolic syndrome (MetS). On the other hand, adiponectin levels are lowered. Since effects of pitavastatin on these parameters have not been reported in hypercholesterolemic patients with MetS, the present study was conducted.
   Purpose: To evaluate the effects of pitavastatin on inflammatory reaction, oxidative stress, and plasma adiponectin levels in hypercholesterolemic MetS patients in a multicenter trial.
   Methods: This open-label, single group study was performed at 7 hospitals in Japan. Pitavastatin (2 mg/day) was administered to 103 consecutive patients with hypercholesterolemia, subdivided into MetS and non-MetS for 12 weeks. Blood samples were collected after overnight fasting at the start of treatment (baseline) and after 12 weeks.
   Results: In the patients with MetS (n = 69), mean values of plasma high-sensitivity C-reactive protein (hs-CRP) were significantly higher and mean values of plasma high-molecular-weight (HMW)-adiponectin significantly lower than in their counterparts without MetS (n = 34). The baseline HMW-adiponectin and high-density lipoprotein cholesterol (HDL-C) values significantly correlated only in the MetS patients (r = 0.318: p = 0.01). In an effectiveness analysis including 94 patients (62 with MetS, 32 without MetS), the level of hs-CRP was significantly decreased in patients with MetS during the drug treatment, whereas HMW-adiponectin did not change. When patients with MetS were divided into two subgroups according to the percent changes in HDL-C, significantly greater increase in HMW-adiponectin by pitavastatin treatment was observed in the HDL-C >= 10% increase subgroup than in the HDL-C < 10% increase subgroup (p = 0.009).
   Conclusion: Twelve weeks administration of pitavastatin, in addition to the antihyperlipidemic effects, may be beneficial as an anti-atherosclerotic therapy in hypercholesterolemic patients with MetS, taking changes in hs-CRP and HMW-adiponectin into consideration. ClinicalTrials.gov identifier: NCT00444717. (c) 2012 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved.
C1 [Matsubara, Tatsuaki] Aichi Gakuin Univ, Sch Dent, Dept Internal Med, Chikusa Ku, Nagoya, Aichi, Japan.
   [Arakawa, Takemi; Nakao, Masahide] Rinko Hosp, Dept Internal Med, Nagoya, Aichi, Japan.
   [Yokoi, Kiyoshi; Oguri, Mitsutoshi] Gifu Prefectural Govt Tajimi Hosp, Dept Cardiol, Tajimi, Japan.
   [Marui, Nobuyuki; Amano, Tetsuya] Chubu Rosai Hosp, Dept Cardiol, Nagoya, Aichi, Japan.
   [Ichimiya, Satoshi; Ohashi, Taiki] Yokkaichi Municipal Hosp, Dept Cardiol, Yokaichi, Japan.
   [Imai, Kenji] Imai Naika Clin, Nagoya, Aichi, Japan.
   [Sakai, Shinichi] Kainan Hosp, Yatomi, Japan.
   [Sugiyama, Satoru] Inst Appl Biochem, Mitake, Tokyo 50501, Japan.
   [Ishii, Hideki; Murohara, Toyoaki] Nagoya Univ, Grad Sch Med, Dept Cardiol, Nagoya, Aichi 4648601, Japan.
C3 Aichi Gakuin University; Nagoya University
RP Matsubara, T (corresponding author), Aichi Gakuin Univ, Sch Dent, Dept Internal Med, Chikusa Ku, 2-11 Suemori Dori, Nagoya, Aichi, Japan.
EM matt@dpc.aichi-gakuin.ac.jp
RI Naruse, Keiko/H-3325-2012; Murohara, Toyoaki/M-4958-2014; Ishii,
   Hideki/M-4871-2014
OI Ishii, Hideki/0000-0003-4348-0123
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NR 42
TC 21
Z9 22
U1 0
U2 5
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0914-5087
J9 J CARDIOL
JI J. Cardiol.
PD NOV-DEC
PY 2012
VL 60
IS 5-6
BP 389
EP 394
DI 10.1016/j.jjcc.2012.07.012
PG 6
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 056HY
UT WOS:000312480200010
PM 22884685
DA 2025-06-11
ER

PT J
AU Ha, MS
   Lee, JH
   Jeong, WM
   Kim, HR
   Son, WH
AF Ha, Min-Seong
   Lee, Jae-Hoon
   Jeong, Woo-Min
   Kim, Hyun Ryun
   Son, Woo Hyeon
TI The Combined Intervention of Aqua Exercise and Burdock Extract
   Synergistically Improved Arterial Stiffness: A Randomized, Double-Blind,
   Controlled Trial
SO METABOLITES
LA English
DT Article
DE aqua exercise; burdock extract; metabolic syndrome; cardiovascular
   disease; vascular endothelial function
ID CORONARY-HEART-DISEASE; METABOLIC SYNDROME; INSULIN-RESISTANCE;
   ENDOTHELIAL DYSFUNCTION; CARDIOVASCULAR-DISEASE; PHYSICAL-ACTIVITY;
   OXIDATIVE STRESS; PROSTAGLANDIN-X; SMOOTH-MUSCLE; NITRIC-OXIDE
AB Metabolic syndrome (MS), characterized by the presence of risk factors for various metabolic disorders, including impaired glucose tolerance, dyslipidemia, hypertension, and insulin resistance, has a high incidence in the Asian population. Among the various approaches used for improving MS, the combination of exercise and nutrition is of increasing importance. In this randomized controlled trial, we evaluated the effects of combined aqua exercise and burdock extract intake on blood pressure, insulin resistance, arterial stiffness, and vascular regulation factors in older women with MS. A total of 42 participants were randomly assigned into one of four groups (control, exercise, burdock, and exercise + burdock) and underwent a 16-week double-blinded intervention. Blood pressure, insulin resistance, arterial stiffness, and vascular regulation factors were evaluated before and after the intervention. The 16-week intervention of aqua exercise decreased the levels of insulin, glucose, homeostasis model assessment of insulin resistance, and thromboxane A2, but increased the levels of the quantitative insulin sensitivity check index and prostaglandin I2. The combined burdock extract intake and aqua exercise intervention had an additional effect, improving the augmentation index, augmentation index at 75 beats per min, and pulse wave velocity. In conclusion, aqua exercise could improve insulin resistance and vascular regulation factors in older women with MS. Furthermore, combined treatment with burdock extract intake could improve arterial stiffness via a synergistic effect.
C1 [Ha, Min-Seong] Dongguk Univ Seoul, Coll Arts, Dept Sports Culture, 30 Pildong Ro 1 Gil, Seoul 04620, South Korea.
   [Lee, Jae-Hoon] Univ Seoul, Dept Sports Sci, 163 Seoulsiripdae Ro, Seoul 02504, South Korea.
   [Jeong, Woo-Min] Wellcare Korea Co Ltd, 26 Wadong Ro, Ansan 15265, South Korea.
   [Kim, Hyun Ryun] Woosuk Univ, Dept Phys Educ, 443 Samnye Ro, Samnye Eup 55338, Wanju Gun, South Korea.
   [Son, Woo Hyeon] Dong A Univ, Inst Convergence Biohlth, 26 Daesingongwon Ro, Busan 49201, South Korea.
C3 Dongguk University; University of Seoul; Woosuk University; Dong A
   University
RP Ha, MS (corresponding author), Dongguk Univ Seoul, Coll Arts, Dept Sports Culture, 30 Pildong Ro 1 Gil, Seoul 04620, South Korea.; Son, WH (corresponding author), Dong A Univ, Inst Convergence Biohlth, 26 Daesingongwon Ro, Busan 49201, South Korea.
EM haminseong@dgu.ac.kr; physical365@gmail.com
RI 손, 우현/JNE-3360-2023
OI Ha, Min-Seong/0000-0003-4852-2038
FU Ministry of Education of the Republic of Korea; National Research
   Foundation of Korea [NRF-2019S1A5B5A07106826]
FX This research was supported by the Ministry of Education of the Republic
   of Korea and the National Research Foundation of Korea
   (NRF-2019S1A5B5A07106826).
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NR 66
TC 3
Z9 3
U1 0
U2 7
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2218-1989
J9 METABOLITES
JI Metabolites
PD OCT
PY 2022
VL 12
IS 10
AR 970
DI 10.3390/metabo12100970
PG 15
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 5P5KQ
UT WOS:000873189900001
PM 36295873
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Domingo, P
   Mateo, MG
   Villarroya, J
   Cereijo, R
   Torres, F
   Domingo, JC
   Campderros, L
   Gallego-Escuredo, JM
   Gutierrez, MD
   Mur, I
   Corbacho, N
   Vidal, F
   Villarroya, F
   Giralt, M
AF Domingo, Pere
   Mateo, Maria Gracia
   Villarroya, Joan
   Cereijo, Ruben
   Torres, Ferran
   Domingo, Joan C.
   Campderros, Laura
   Gallego-Escuredo, Jose M.
   Gutierrez, Maria del Mar
   Mur, Isabel
   Corbacho, Noemi
   Vidal, Francesc
   Villarroya, Francesc
   Giralt, Marta
TI Increased Circulating Levels of Growth Differentiation Factor 15 in
   Association with Metabolic Disorders in People Living with HIV Receiving
   Combined Antiretroviral Therapy
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Article
DE GDF15; cardiovascular risk; Framingham; D; A; insulin resistance;
   metabolic syndrome; HALS
ID CARDIOVASCULAR-DISEASE; RISK PREDICTION; LIPODYSTROPHY; DYSFUNCTION;
   INFECTION; ABACAVIR; PROFILE; EVENTS; STRESS; MARKER
AB Objective: People living with HIV (PLWH) have an increased cardiovascular risk (CVR) owing to dyslipidemia, insulin resistance, metabolic syndrome, and HIV/combination antiretroviral therapy (cART)-associated lipodystrophy (HALS). Atherosclerosis and inflammation are related to growth differentiation factor-15 (GDF15). The relationship between metabolic disturbances, HALS, and CVR with GDF15 in PLWH is not known. Research design and methods: Circulating GDF15 levels in 152 PLWH (with HALS = 60, without HALS = 43, cART-naive = 49) and 34 healthy controls were assessed in a cross-sectional study. Correlations with lipids, glucose homeostasis, fat distribution, and CVR were explored. Results: PLWH had increased circulating GDF15 levels relative to controls. The increase was the largest in cART-treated PLWH. Age, homeostatic model assessment of insulin resistance 1 (HOMA1-IR), HALS, dyslipidemia, C-reactive protein, and CVR estimated with the Framingham score correlated with GDF15 levels. The GDF15-Framingham correlation was lost after age adjustment. No correlation was found between GDF15 and the D:A:D Data Collection on Adverse Effects of Anti-HIV Drugs (D:A:D) score estimated CVR. CVR independent predictors were patient group (naive, HALS-, and HALS+) and cumulated protease inhibitor or nucleoside reverse transcriptase inhibitor exposure. Conclusions: PLWH, especially when cART-treated, has increased GDF15 levels-this increase is associated with dyslipidemia, insulin resistance, metabolic syndrome, HALS, and inflammation-related parameters. GDF15 is unassociated with CVR when age-adjusted.
C1 [Domingo, Pere; Mateo, Maria Gracia; Villarroya, Joan; Cereijo, Ruben; Gallego-Escuredo, Jose M.; Gutierrez, Maria del Mar; Mur, Isabel; Corbacho, Noemi] Inst Recerca Hosp Santa Creu & St Pau, Infect Dis Unit, Barcelona 08041, Spain.
   [Villarroya, Joan; Cereijo, Ruben; Domingo, Joan C.; Campderros, Laura; Gallego-Escuredo, Jose M.; Villarroya, Francesc; Giralt, Marta] Inst Biomed Univ Barcelona IBUB, CIBER Fisiopatol Obesidad & Nutr CIBEROBN, Dept Biochem & Mol Biomed, Barcelona 08028, Spain.
   [Torres, Ferran] Hosp Clin Barcelona, IDIBAPS, Biostat & Data Management Core Facil, Barcelona 08036, Spain.
   [Torres, Ferran] Univ Autonoma Barcelona, Fac Med, Biostat Unit, Barcelona 08193, Spain.
   [Vidal, Francesc] Univ Rovira & Virgili, Hosp Univ Joan XXIII, Dept Internal Med, Infect Dis Unit,IISPV, Tarragona 43003, Spain.
C3 Hospital of Santa Creu i Sant Pau; CIBER - Centro de Investigacion
   Biomedica en Red; CIBEROBN; University of Barcelona; Hospital Clinic de
   Barcelona; IDIBAPS; Autonomous University of Barcelona; University of
   Barcelona; Universitat Rovira i Virgili; Institut d'Investigacio
   Sanitaria Pere Virgili (IISPV)
RP Domingo, P (corresponding author), Inst Recerca Hosp Santa Creu & St Pau, Infect Dis Unit, Barcelona 08041, Spain.
EM pdomingo@santpau.cat; mmateog@santpau.cat; jvillarroya@ub.edu;
   rcereijo@santpau.cat; Ferran.Torres@uab.cat; Ferran.Torres@uab.cat;
   jcdomingo@ub.edu; lcampderros@ub.edu; MGutierrezMa@santpau.cat;
   imur@santpau.cat; ncorbacho@santpau.cat; fvidal@comt.es;
   fvillarroya@ub.edu; mgiralt@ub.edu
RI Campderros, Laura/AAM-4550-2021; Domingo, Pere/CAH-9641-2022;
   Villarroya, Joan/W-4066-2018; Villarroya, Francesc/K-4357-2014; Rodero,
   Félix/Q-7880-2018; Cereijo, Rubén/C-2718-2014; Torres,
   Ferran/D-1296-2011; Cereijo, Ruben/K-3556-2017; Domingo Pedrol, Joan
   Carles/A-4856-2019; Giralt, Marta/A-4756-2013
OI Cereijo, Ruben/0000-0002-1108-230X; Campderros,
   Laura/0000-0003-4377-034X; Domingo Pedrol, Joan
   Carles/0000-0002-6356-0836; Giralt, Marta/0000-0001-7968-4190; Torres,
   Ferran/0000-0002-7355-7913; Domingo, Pere/0000-0003-1138-5770
FU Instituto de Salud Carlos III [PI14/0063, PI14/0700, PI016/0503,
   PI17/0420, PI17/0498, PI20/0106, PI20/0137]; AEI/FEDER, Ministerio de
   Sanidad, Politica Social e Igualdad [EC11-293]; Ministerio de Ciencia e
   Innovacion [IJC2018-037142-I, MCIN/AEI/10.13039/501100011033]; Programa
   de Suport als Grups de Recerca AGAUR [2014-SGR-250, 2017-SGR-948,
   RD012/0017/0014, RD12/0017/0005]; FEDER [GLD 1300168]
FX FundingThis work has been partially funded by Instituto de Salud Carlos
   III (PI14/0063, PI14/0700, PI016/0503, PI17/0420, PI17/0498, PI20/0106
   and PI20/0137) AEI/FEDER, Ministerio de Sanidad, Politica Social e
   Igualdad (EC11-293), Ministerio de Ciencia e Innovacion (grant
   IJC2018-037142-I, funded by the MCIN/AEI/10.13039/501100011033),
   Programa de Suport als Grups de Recerca AGAUR (2014-SGR-250,
   2017-SGR-948), and Red de Investigacion en SIDA RD012/0017/0014,
   RD12/0017/0005 integrated in the National RDI Plan and cofinanced by the
   ISCIII-Subdireccion General de Evaluacion and FEDER; FEDER (Fondo
   Europeo de desarrollo Regional; otra manera de hacer Europa), and by the
   Gilead Fellowship Program (I Convocatoria de Proyectos de Investigacion
   en VIH y Hepatitis 2013, GLD 1300168, and II Convocatoria de Proyectos
   de Investigacion en VIH y Hepatitis GLD 2014/00923. The funding sources
   were not involved in the design of the study, in the collection and
   analysis of data or in writing the report. All authors had access to the
   data used in the analyses and the lead author reviewed the full data
   report. The full study data were available to all authors. The decision
   to submit the paper for publication was made by P.D., M.G.M., F.V. and
   M.G.
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NR 51
TC 5
Z9 5
U1 0
U2 4
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD FEB
PY 2022
VL 11
IS 3
AR 549
DI 10.3390/jcm11030549
PG 13
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA ZF8SS
UT WOS:000759840200001
PM 35160008
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Kim, JS
   Kim, YJ
   Ahn, SH
   Kim, BJ
AF Kim, Jong S.
   Kim, Yeon-Jung
   Ahn, Sung-Ho
   Kim, Bum J.
TI Location of cerebral atherosclerosis: Why is there a difference between
   East and West?
SO INTERNATIONAL JOURNAL OF STROKE
LA English
DT Review
DE Intracranial atherosclerosis; risk factor; metabolic syndrome; gene;
   Asia
ID CLASSIC RISK-FACTORS; METABOLIC SYNDROME; INTRACRANIAL ATHEROSCLEROSIS;
   RACIAL-DIFFERENCES; MOYAMOYA-DISEASE; GENETIC VARIANT;
   CEREBROVASCULAR-DISEASE; GENOMEWIDE ASSOCIATION; ARTERY ATHEROSCLEROSIS;
   EXTRACRANIAL ARTERIES
AB Intracranial atherosclerosis is more prevalent in Asian patients, whereas extracranial atherosclerosis is more common in individuals from western countries. The reasons for this discrepancy remain unknown. We reviewed the relevant literature and discussed the currently available information. Although the study population, diagnostic modality, and risk factor definitions differ between studies, hypercholesterolemia is more correlated with extracranial atherosclerosis than intracranial atherosclerosis. The difference in hypercholesterolemia prevalence is one of the main reasons for racial differences. Intracranial arteries contain higher antioxidant level than extracranial arteries and may be more vulnerable to risk factors for antioxidant depletion (e.g., metabolic syndrome and diabetes mellitus). Intracranial arteries may be vulnerable to factors associated with hemodynamic stress (e.g., advanced, salt-retaining hypertension and arterial tortuosity) because of a smaller diameter, thinner media and adventitia, and fewer elastic medial fibers than extracranial arteries. Additionally, non-atherosclerotic arterial diseases (e.g., moyamoya disease) that commonly occur in the intracranial arteries of East Asians may contaminate the reports of intracranial atherosclerosis cases. Genes, including RNF 213 or those associated with high salt sensitivity, may also explain racial differences in atherosclerotic location. To understand racial differences, further well-designed studies on various risk and genetic factors should be performed in patients with cerebral atherosclerosis. Additionally, improvements in diagnostic accuracy via advancements in imaging technologies and increased genetic data will aid in the differentiation of atherosclerosis from non-atherosclerotic intracranial diseases.
C1 [Kim, Jong S.; Kim, Yeon-Jung; Ahn, Sung-Ho; Kim, Bum J.] Univ Ulsan, Dept Neurol, Asan Med Ctr, Seoul, South Korea.
C3 University of Ulsan; Asan Medical Center
RP Kim, JS (corresponding author), Univ Ulsan, Dept Neurol, Asan Med Ctr, Coll Med, Asanbyeongwon Gil 86, Seoul 138736, South Korea.
EM jongskim@amc.seoul.kr
RI Kim, Bum Joon/S-2156-2017
FU Ministry of Health, Welfare and Family Affairs, Republic of Korea
   [HI14C1985]
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: This study
   was supported by a grant from Ministry of Health, Welfare and Family
   Affairs, Republic of Korea (HI14C1985).
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NR 82
TC 60
Z9 65
U1 1
U2 19
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1747-4930
EI 1747-4949
J9 INT J STROKE
JI Int. J. Stroke
PD JAN
PY 2018
VL 13
IS 1
BP 35
EP 46
DI 10.1177/1747493016647736
PG 12
WC Clinical Neurology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Cardiovascular System & Cardiology
GA FP8CU
UT WOS:000417868600006
PM 27145795
DA 2025-06-11
ER

PT J
AU Waldstein, SR
   Katzel, LI
AF Waldstein, SR
   Katzel, LI
TI Interactive relations of central versus total obesity and blood pressure
   to cognitive function
SO INTERNATIONAL JOURNAL OF OBESITY
LA English
DT Article
DE central obesity; blood pressure; cognitive function; cognition;
   neuropsychology
ID BODY-MASS INDEX; METABOLIC SYNDROME; RISK-FACTORS; STROKE; STRESS;
   ABNORMALITIES; HYPERTENSION; REACTIVITY; MORTALITY; RELEVANCE
AB Objective: To examine the potential interactive relations of central versus total obesity and blood pressure ( BP) to cognitive function.
   Method: In all, 90 healthy, stroke, and dementia-free middle-aged and older adults ( ages 54-81 years; 63% male; 93% White) underwent biomedical and neuropsychological assessment. Relations of central obesity ( assessed by waist circumference (WC)) and systolic or diastolic BP to cognitive function were examined in multiple regression models. Next, body mass index (BMI) was substituted for WC in the models.
   Results: After statistical adjustment for age, education, gender, and other potential confounders including components of the metabolic syndrome (depending on the model), significant interactions of WC and systolic (or diastolic) BP were noted for the Grooved Pegboard-Dominant Hand and Stroop Interference scores, with marginally significant results for Grooved Pegboard Nondominant Hand. In general, individuals with greater WC and higher BP performed most poorly on these measures. Similar results were obtained for BMI.
   Conclusion: Independent of other confounders including facets of the metabolic syndrome, the combination of greater WC (or BMI) and higher (systolic or diastolic) BP was associated with diminished performance on tests of motor speed and manual dexterity, and executive function (i.e. response inhibition) accounting for 3-13% of the variance in these measures. In healthy older adults, there are similar, negative relations of central and total obesity to cognitive function that are potentiated by higher BP levels.
C1 Univ Maryland Baltimore Cty, Dept Psychol, Baltimore, MD 21250 USA.
   Univ Maryland, Sch Med, Div Gerontol, Dept Med, Baltimore, MD 21201 USA.
   Baltimore Vet Affairs Med Ctr, Geriatr Res Educ & Clin Ctr, Baltimore, MD USA.
C3 University System of Maryland; University of Maryland Baltimore County;
   University System of Maryland; University of Maryland Baltimore; US
   Department of Veterans Affairs; Veterans Health Administration (VHA);
   Baltimore VA Medical Center; Geriatric Research Education & Clinical
   Center
RP Univ Maryland Baltimore Cty, Dept Psychol, 1000 Hilltop Circle, Baltimore, MD 21250 USA.
EM waldstei@umbc.edu
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NR 35
TC 150
Z9 174
U1 0
U2 18
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0307-0565
EI 1476-5497
J9 INT J OBESITY
JI Int. J. Obes.
PD JAN
PY 2006
VL 30
IS 1
BP 201
EP 207
DI 10.1038/sj.ijo.0803114
PG 7
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 992SQ
UT WOS:000233904700030
PM 16231030
DA 2025-06-11
ER

PT J
AU Litwin, M
   Feber, J
AF Litwin, Mieczyslaw
   Feber, Janusz
TI Origins of Primary Hypertension in Children Early Vascular or Biological
   Aging?
SO HYPERTENSION
LA English
DT Review
DE adolescent; brachial artery; cardiovascular disease; dilation; metabolic
   syndrome
ID INTIMA-MEDIA THICKNESS; BODY-MASS INDEX; ASSISTED REPRODUCTIVE
   TECHNOLOGIES; CARDIOVASCULAR RISK-FACTORS; ELEVATED BLOOD-PRESSURE;
   PULSE-WAVE VELOCITY; ARTERIAL STIFFNESS; METABOLIC-SYNDROME; OXIDATIVE
   STRESS; PHYSICAL-ACTIVITY
AB Although relatively rare in childhood, primary hypertension (PH) is thought to have originated in childhood and may be even determined perinatally. PH prevalence increases in school-age children and affects 11% of 18-year-old adolescents. Associated with metabolic risk factors, elevated blood pressure in childhood is carried into adulthood. Analysis of the phenotype of hypertensive children has revealed that PH is a complex of anthropometric and neuro-immuno-metabolic abnormalities, typically found in hypertensive adults. Children with elevated blood pressure have shown signs of accelerated biological development, which are closely associated with further development of PH, metabolic syndrome, and cardiovascular disease in adulthood. At the time of diagnosis, hypertensive children were reported to have significant arterial remodelling expressed as significantly increased carotid intima-media thickness, increased stiffness of large arteries, lower area of microcirculation, and decreased endothelial function. These changes indicate that their biological age is 4 to 5 years older than their normotensive peers. All these abnormalities are typical features of early vascular aging described in adults with PH. However, as these early vascular changes in hypertensive children are closely associated with features of accelerated biological development and neuro-immuno-metabolic abnormalities observed in older subjects, it seems that PH in childhood is not only an early vascular aging event, but also an early biological maturation phenomenon.
C1 [Litwin, Mieczyslaw] Childrens Mem Hlth Inst, Dept Nephrol & Arterial Hypertens, Warsaw, Poland.
   [Feber, Janusz] Childrens Mem Hlth Inst, Div Nephrol, Dept Pediat, Warsaw, Poland.
   [Litwin, Mieczyslaw] Ctr Postgrad Med Educ, Chair Pediat Nephrol, Warsaw, Poland.
C3 Children's Memorial Health Institute; Children's Memorial Health
   Institute; Centre of Postgraduate Medical Education - Poland
RP Litwin, M (corresponding author), Childrens Mem Hlth Inst, Dept Nephrol Kidney Transplantat & Arterial Hyper, Aleja Dzieci Polskich 20, PL-04730 Warsaw, Poland.
EM m.litwin@ipczd.pl
RI Feber, Janusz/LTD-8835-2024; Litwin, Mieczyslaw/L-4648-2017
OI Litwin, Mieczyslaw/0000-0002-5241-2483
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NR 130
TC 28
Z9 28
U1 0
U2 13
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0194-911X
EI 1524-4563
J9 HYPERTENSION
JI Hypertension
PD NOV
PY 2020
VL 76
IS 5
BP 1400
EP 1409
DI 10.1161/HYPERTENSIONAHA.120.14586
PG 10
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA NY2RZ
UT WOS:000576244500011
PM 32981361
DA 2025-06-11
ER

PT J
AU Arozal, W
   Louisa, M
   Soetikno, V
AF Arozal, Wawaimuli
   Louisa, Melva
   Soetikno, Vivian
TI Selected Indonesian Medicinal Plants for the Management of Metabolic
   Syndrome: Molecular Basis and Recent Studies
SO FRONTIERS IN CARDIOVASCULAR MEDICINE
LA English
DT Review
DE curcumin; cinnamon; mangosteen; Indonesia; metabolic syndrome
ID HIGH-FAT DIET; ATTENUATES DIABETIC-NEPHROPATHY; TYROSINE-PHOSPHATASE 1B;
   GARCINIA-MANGOSTANA L.; TURMERIC CURCUMA-LONGA; NF-KAPPA-B;
   ALPHA-MANGOSTIN; INSULIN-RESISTANCE; OXIDATIVE STRESS; GUT MICROBIOTA
AB Increased prevalence of metabolic syndrome (MetS) in the world influences quality of health in all respective countries, including Indonesia. Data from Indonesian Family Life Survey reported in 2019 showed that the prevalence of MetS in Indonesia currently is 21.66%, estimated with the provincial incidence ranging up to 50%; additionally, the most common components of MetS discovered in Indonesia were poor high-density lipoprotein (HDL) cholesterol and hypertension. Management treatment of MetS involves a combination of lifestyle changes and pharmacological interventions to decrease cerebrovascular disease. Various natural substances have been shown to govern any cardiovascular or metabolic disorders through different mechanisms, such as triggering anti-inflammation, lipid profile correction, sensitization of insulin reception, or blood glucose control. In Indonesia, the utilization of natural compounds is part of the nation's culture. The community widely uses them; even though in general, their effectiveness and safety have not been thoroughly assessed by rigorous clinical trials. Scientific evidence suggested that cinnamon, mangosteen, and curcumin, as well as their derived components possess a broad spectrum of pharmacological activity. In this review, an enormous potential of cinnamon, mangosteen, and curcumin, which originated and are commonly used in Indonesia, could be treated against MetS, such as diabetes, hyperlipidemia, hypertension, and obesity. The findings suggested that cinnamon, mangosteen, curcumin and their derivatives may reflect areas of promise in the management of MetS.
C1 [Arozal, Wawaimuli; Louisa, Melva; Soetikno, Vivian] Univ Indonesia, Dept Pharmacol & Therapeut, Fac Med, Jakarta, Indonesia.
C3 University of Indonesia
RP Arozal, W (corresponding author), Univ Indonesia, Dept Pharmacol & Therapeut, Fac Med, Jakarta, Indonesia.
EM wawaimuli@gmail.com
RI Louisa, Melva/HNI-7441-2023
FU Direktorat Jendral Pendidikan Tinggi Republic Indonesia
FX We thanked Direktorat Jendral Pendidikan Tinggi Republic Indonesia for
   the funding support. This fund was received for open access publication
   fees.
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NR 162
TC 13
Z9 15
U1 0
U2 15
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2297-055X
J9 FRONT CARDIOVASC MED
JI Front. Cardiovasc. Med.
PD MAY 6
PY 2020
VL 7
AR 82
DI 10.3389/fcvm.2020.00082
PG 16
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA LS8KI
UT WOS:000536629400001
PM 32435657
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Hirata, A
   Kishida, K
   Nakatsuji, H
   Hiuge-Shimizu, A
   Funahashi, T
   Shimomura, I
AF Hirata, Ayumu
   Kishida, Ken
   Nakatsuji, Hideaki
   Hiuge-Shimizu, Aki
   Funahashi, Tohru
   Shimomura, Iichiro
TI High serum S100A8/A9 levels and high cardiovascular complication rate in
   type 2 diabetics with ultrasonographic low carotid plaque density
SO DIABETES RESEARCH AND CLINICAL PRACTICE
LA English
DT Article
DE S100A8/A9 complex; Adiponectin; Vulnerable blood; Vulnerable plaque
ID MYELOID-RELATED PROTEIN-14; NADPH OXIDASE ACTIVATION; ACUTE CORONARY
   SYNDROMES; BIOELECTRICAL-IMPEDANCE; ATHEROSCLEROTIC PLAQUES;
   RHEUMATOID-ARTHRITIS; METABOLIC SYNDROME; OXIDATIVE STRESS;
   ARACHIDONIC-ACID; ARTERY-DISEASE
AB Aims: S100A8/A9 complex is an inflammation-associated biomarker, which binds toll-like receptor 4 and was associated with the receptor for advanced glycation end-products. S100A8 and S100A9 were accumulated in atherosclerotic lesions. High serum levels of S100A8/A9 are associated with acute coronary syndrome and atherosclerosis in type 2 diabetes mellitus (T2DM). However, association between serum S100A8/A9 levels and vulnerable plaque remains unclear. The present study investigated the relation between serum S100A8/A9 levels and relative plaque density (RPD) of the carotid artery determined by ultrasonography in T2DM.
   Methods: The study subjects were 72 consecutive T2DM outpatients (males/females = 42/30), who underwent the carotid artery ultrasonography. RPD in the carotid artery was calculated by the formula; RPD = [density of the carotid plaque/density of vessel lumen]. Serum levels of adiponectin and S100A8/A9 were measured.
   Results: The median RPD was 2.1. Patients with low RPD (<= 2.1) were significantly more likely to have metabolic syndrome, nephropathy, coronary artery disease, and peripheral artery disease, and higher levels of S100A8/A9, S100A8/A9-to-adiponectin ratio, and uric acid, compared to those with high RPD (> 2.1).
   Conclusions: T2DM patients with low RPD had higher prevalence of metabolic syndrome, cardiovascular diseases and higher serum S100A8/A9 levels, compared to those with high RPD. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
C1 [Kishida, Ken; Funahashi, Tohru] Osaka Univ, Grad Sch Med, Dept Metab & Atherosclerosis, Suita, Osaka 5650871, Japan.
   [Hirata, Ayumu; Kishida, Ken; Nakatsuji, Hideaki; Hiuge-Shimizu, Aki; Funahashi, Tohru; Shimomura, Iichiro] Osaka Univ, Grad Sch Med, Dept Metab Med, Suita, Osaka 5650871, Japan.
C3 The University of Osaka; The University of Osaka
RP Kishida, K (corresponding author), Osaka Univ, Grad Sch Med, Dept Metab & Atherosclerosis, 2-2 B-5 Yamada Oka, Suita, Osaka 5650871, Japan.
EM kkishida@imed2.med.osaka-u.ac.jp
FU Kowa Co. Ltd.; (Research in a proposed research area) "Molecular Basis
   and Disorders of Control of Appetite and Fat Accumulation" [22126008];
   Grants-in-Aid for Scientific Research [22126008] Funding Source: KAKEN
FX The authors declare that they have no conflict of interest. Ken Kishida
   and Tohru Funahashi are members of the "Department of Metabolism and
   Atherosclerosis'', a sponsored course endowed by Kowa Co. Ltd. and a
   company researcher is dispatched to the course.We thank all staff at
   "Diabetes & Metabolic Station'' for the excellent medical care, Dr.
   Norikazu Maeda for patient enrolment, and Mrs Yoko Motomura and Miyuki
   Nakamura for the excellent technical assistance. This research was
   supported in part by a Grant-in-Aid for Scientific Research on
   Innovative Areas (Research in a proposed research area) "Molecular Basis
   and Disorders of Control of Appetite and Fat Accumulation" (#22126008,
   to T. F. and K. K., Chiyoda, Tokyo, Japan).
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NR 40
TC 25
Z9 32
U1 0
U2 4
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0168-8227
J9 DIABETES RES CLIN PR
JI Diabetes Res. Clin. Pract.
PD JUL
PY 2012
VL 97
IS 1
BP 82
EP 90
DI 10.1016/j.diabres.2012.01.026
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 977JS
UT WOS:000306655500018
PM 22333479
DA 2025-06-11
ER

PT J
AU Yavorov-Dayliev, D
   Milagro, FI
   Ayo, J
   Oneca, M
   Aranaz, P
AF Yavorov-Dayliev, Deyan
   Milagro, Fermin I.
   Ayo, Josune
   Oneca, Maria
   Aranaz, Paula
TI Pediococcus acidilactici CECT9879 (pA1c) Counteracts the Effect
   of a High-Glucose Exposure in C. elegans by Affecting the Insulin
   Signaling Pathway (IIS)
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE probiotic; diabetes; obesity; Caenorhabditis elegans;
   insulin-signaling-pathway; beta-oxidation; daf-16
ID CAENORHABDITIS-ELEGANS; LIFE-SPAN; FAT ACCUMULATION; OXIDATIVE STRESS;
   GUT MICROBIOTA; OBESITY; RESVERATROL; METABOLISM; DAF-16; MODEL
AB The increasing prevalence of metabolic syndrome-related diseases, including type-2 diabetes and obesity, makes it urgent to develop new alternative therapies, such as probiotics. In this study, we have used Caenorhabditis elegans under a high-glucose condition as a model to examine the potential probiotic activities of Pediococcus acidilactici CECT9879 (pA1c). The supplementation with pA1c reduced C. elegans fat accumulation in a nematode growth medium (NGM) and in a high-glucose (10 mM) NGM medium. Moreover, treatment with pA1c counteracted the effect of the high glucose by reducing reactive oxygen species by 20%, retarding the aging process and extending the nematode median survival (> 2 days in comparison with untreated control worms). Gene expression analyses demonstrated that the probiotic metabolic syndrome-alleviating activities were mediated by modulation of the insulin/IGF-1 signaling pathway (IIS) through the reversion of the glucose-nuclear-localization of daf-16 and the overexpression of ins-6 and daf-16 mediators, increased expression of fatty acid (FA) peroxisomal beta-oxidation genes, and downregulation of FA biosynthesis key genes. Taken together, our data suggest that pA1c could be considered a potential probiotic strain for the prevention of the metabolic syndrome-related disturbances and highlight the use of C. elegans as an appropriate in vivo model for the study of the mechanisms underlying these diseases.
C1 [Yavorov-Dayliev, Deyan; Ayo, Josune; Oneca, Maria] Genbioma Aplicac SL Poligono Ind Noain Esquiroz, Calle S,Nave 4, Esquiroz 31191, Spain.
   [Yavorov-Dayliev, Deyan; Milagro, Fermin I.; Aranaz, Paula] Univ Navarra, Fac Pharm & Nutr, Ctr Nutr Res, Pamplona 31008, Spain.
   [Milagro, Fermin I.; Aranaz, Paula] Navarra Inst Hlth Res IdiSNA, Pamplona 31008, Spain.
   [Milagro, Fermin I.] Inst Salud Carlos III, Ctr Invest Biomed Red Fisiopatol Obes & Nutr CIBE, Madrid 28029, Spain.
C3 University of Navarra; University of Navarra; Instituto de Salud Carlos
   III; CIBER - Centro de Investigacion Biomedica en Red; CIBEROBN
RP Milagro, FI (corresponding author), Univ Navarra, Fac Pharm & Nutr, Ctr Nutr Res, Pamplona 31008, Spain.; Milagro, FI (corresponding author), Navarra Inst Hlth Res IdiSNA, Pamplona 31008, Spain.; Milagro, FI (corresponding author), Inst Salud Carlos III, Ctr Invest Biomed Red Fisiopatol Obes & Nutr CIBE, Madrid 28029, Spain.
EM deyan@genbioma.com; fmilagro@unav.es; josune@genbioma.com;
   maria@genbioma.com; paranaz@unav.es
RI Milagro, Fermin/F-2315-2015
OI Milagro, Fermin I./0000-0002-3228-9916; Yavorov Dayliev,
   Deyan/0000-0002-7901-0695; Ayo, Josune/0000-0002-2379-0442
FU Government of Navarra [0011-1408-2020-000010]; Genbioma Aplicaciones
   S.L.; Spanish Ministry of Science and Innovation (Ayudas para contratos
   Torres Quevedo) [PTQ2019-010384/AEI/10.13039/501100011033]; CIBERobn
   grant [CB12/03/30002]
FX This research was funded by a grant from Government of Navarra (Ayudas
   para la contratacion de doctorandos y doctorandas Doctorados
   industriales 2020) [Reference: 0011-1408-2020-000010]. This study was
   also funded by grants from Genbioma Aplicaciones S.L., M.O. is supported
   by Torres-Quevedo grants from the Spanish Ministry of Science and
   Innovation (Ayudas para contratos Torres Quevedo
   PTQ2019-010384/AEI/10.13039/501100011033). F.I.M. is supported by
   CIBERobn grant (Grant number: CB12/03/30002).
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NR 93
TC 18
Z9 18
U1 9
U2 67
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD MAR
PY 2022
VL 23
IS 5
AR 2689
DI 10.3390/ijms23052689
PG 18
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA ZY9YK
UT WOS:000772934400001
PM 35269839
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Lopez-Legarrea, P
   de la Iglesia, R
   Abete, I
   Navas-Carretero, S
   Martinez, JA
   Zulet, MA
AF Lopez-Legarrea, Patricia
   de la Iglesia, Rocio
   Abete, Itziar
   Navas-Carretero, Santiago
   Alfredo Martinez, J.
   Angeles Zulet, M.
TI The protein type within a hypocaloric diet affects obesity-related
   inflammation: The RESMENA project
SO NUTRITION
LA English
DT Article
DE Cardiovascular diseases; Inflammation markers; Macronutrient
   distribution; Weight loss; Metabolic syndrome
ID C-REACTIVE PROTEIN; WEIGHT-LOSS; ADIPOSE-TISSUE; POSTMENOPAUSAL WOMEN;
   ENDOTHELIAL FUNCTION; METABOLIC SYNDROME; OXIDATIVE STRESS; GLYCEMIC
   INDEX; FATTY-ACIDS; MEAT INTAKE
AB Objectives: The aim of this study was to compare the effect of two energy-restricted, differing with regard to protein content, on the inflammation state of obese individuals with features of metabolic syndrome.
   Methods: Ninety-six participants completed an 8-wk randomized intervention trial that compared the RESMENA diet (-30% energy, with 30% energy from protein) with a control diet (-30% energy, with 15% energy from protein) that was based on American Heart Association criteria.
   Results: The mean body weight losses were 7.09 +/- 0.82 kg and 6.73 +/- 0.71 kg, respectively, with no differences seen between the groups. The endpoint inflammation score which was based on high-sensitivity C-reactive protein, interleukin-6, tumor necrosis factor-alpha, and plasminogen activator inhibitor-1 levels was significantly lower (P = 0.012) in the low-protein group (6.81 +/- 232 versus 7.94 +/- 1.94). The linear regression analyses revealed that total protein intake was positively associated with inflammation (P = 0.007) as well as with animal protein (P = 0.025) and meat protein (P = 0.015), but neither vegetable- nor fish-derived proteins were found to influence inflammatory status.
   Conclusions: Our results suggest that the type of protein consumed (more than the total protein consumed) within an energy-restricted diet influences the inflammation status associated with obesity-related comorbidities. (C) 2014 Elsevier Inc. All rights reserved.
C1 [Lopez-Legarrea, Patricia; de la Iglesia, Rocio; Navas-Carretero, Santiago; Alfredo Martinez, J.; Angeles Zulet, M.] Univ Navarra, Dept Nutr Food Sci & Physiol, E-31080 Pamplona, Spain.
   [Abete, Itziar] Biodonostia Hlth Res Inst, San Sebastian, Spain.
   [Abete, Itziar; Navas-Carretero, Santiago; Alfredo Martinez, J.; Angeles Zulet, M.] CIBERobn, Carlos Hlth Inst 3, Madrid, Spain.
C3 University of Navarra; Instituto de Investigacion Sanitaria Biogipuzkoa;
   CIBER - Centro de Investigacion Biomedica en Red; CIBEROBN
RP Martinez, JA (corresponding author), Univ Navarra, Dept Nutr Food Sci & Physiol, E-31080 Pamplona, Spain.
EM jalfmtz@unav.es
RI de la Iglesia, Rocio/ABC-6189-2020; Abete, Itziar/H-4827-2017; Martinez
   Hernandez, J Alfredo/K-8709-2014; Navas-Carretero, Santiago/L-2918-2015;
   Zulet, M. Angeles/H-1317-2017
OI Abete, Itziar/0000-0002-6475-5387; Martinez Hernandez, J
   Alfredo/0000-0001-5218-6941; Navas-Carretero,
   Santiago/0000-0002-5163-2230; de la Iglesia, Rocio/0000-0002-7472-3565;
   Zulet, M. Angeles/0000-0002-3926-0892
FU Health Department of the Government of Navarra [48/2009]; Linea Especial
   about Nutrition, Obesity and Health (University of Navarra) [LE/97];
   CIBERobn; RETICS; Government of Navarra [233/2009]
FX This work was supported by the Health Department of the Government of
   Navarra (48/2009), the Linea Especial about Nutrition, Obesity and
   Health (University of Navarra LE/97), and CIBERobn and RETICS. The
   Government of Navarra provided a predoctoral research grant to Patricia
   Lopez-Legarrea (Predoctoral no. 233/2009). We acknowledge the
   volunteers, the physician Blanca Martinez de Morentin, the nurse Salome
   Perez, and the technician Veronica Ciaurriz for their excellent
   technical assistance.
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NR 42
TC 55
Z9 61
U1 0
U2 17
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0899-9007
EI 1873-1244
J9 NUTRITION
JI Nutrition
PD APR
PY 2014
VL 30
IS 4
BP 424
EP 429
DI 10.1016/j.nut.2013.09.009
PG 6
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA AD8UZ
UT WOS:000333542500009
PM 24607301
DA 2025-06-11
ER

PT J
AU Jialal, I
   Devaraj, S
   Singh, U
   Huet, BA
AF Jialal, I.
   Devaraj, S.
   Singh, U.
   Huet, B. A.
TI Decreased number and impaired functionality of endothelial progenitor
   cells in subjects with metabolic syndrome: Implications for increased
   cardiovascular risk
SO ATHEROSCLEROSIS
LA English
DT Article
DE CD34+KDR+ cells; EPC functions; CRP; Metabolic Syndrome
ID CORONARY-ARTERY-DISEASE; C-REACTIVE PROTEIN; VASCULAR COMPLICATIONS;
   OXIDATIVE STRESS; DYSFUNCTION; INFLAMMATION; HYPERTENSION; MOBILIZATION;
   ASSOCIATION; PREVALENCE
AB Objective: Metabolic syndrome (MetS) is characterized by low-grade inflammation and confers an increased risk for cardiovascular disease. Endothelial progenitor cells (EPCs) are a measure of vascular health and are decreased in patients with various risk factors for cardiovascular disease (CVD). There is a paucity of data examining the EPC status especially in terms of their functionality in MetS subjects without diabetes or cardiovascular disease. We aimed to enumerate and functionally characterize EPCs in subjects with MetS in comparison to healthy controls.
   Methods: The study was performed at the University of California Davis Medical Center. Healthy controls (n = 31) and MetS (n = 46) subjects were included in the study. EPCs were enumerated in fasting blood by KDR/CD34 dual positivity. Functionality was assessed by the colony forming units (CFU) assay, migration and tubule formation.
   Results: Subjects with MetS had significantly decreased number of EPCs compared to control subjects. Furthermore, EPCs from MetS subjects depicted significantly impaired clonogenic capacity, i.e., decreased colony forming units, and impaired capacity to incorporate into tubular structures suggesting functional impairment of EPCs from MetS subjects.
   Conclusions: We make the novel observation that MetS subjects without diabetes or CVD have decreased EPC number and impaired functionality as compared to control subjects. These. findings could contribute to the increased CV risk in this population. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
C1 [Jialal, I.] UC Davis Med Ctr, Lab Atherosclerosis & Metab Res, Dept Med Pathol & Lab Med, Sacramento, CA 95817 USA.
   VA Med Ctr, Mather, CA USA.
C3 University of California System; University of California Davis
RP Jialal, I (corresponding author), UC Davis Med Ctr, Lab Atherosclerosis & Metab Res, Dept Med Pathol & Lab Med, 4635,2nd Ave,Room 3000,Res Bldg 1, Sacramento, CA 95817 USA.
EM ijialal@ucdavis.edu
RI Jialal, Ishwarlal/AAG-6218-2019
FU ADA; NIH [K24 (AT00596)]; National Center for Research Resources(NCRR),
   National Institutes of Health (NIH) [UL1 RR024146]
FX The study was supported by ADA grant (IJ) and NIH K24 (AT00596, IJ) and
   UL1 RR024146 from the National Center for Research Resources(NCRR), a
   component of the National Institutes of Health (NIH), and to CTSC.
   Authors acknowledge assistance of Long Wang, PhD in assisting with
   subject recruitment and Manpreet Kaur for editorial assistance.
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NR 33
TC 92
Z9 99
U1 0
U2 3
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0021-9150
EI 1879-1484
J9 ATHEROSCLEROSIS
JI Atherosclerosis
PD JUL
PY 2010
VL 211
IS 1
BP 297
EP 302
DI 10.1016/j.atherosclerosis.2010.01.036
PG 6
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 620VV
UT WOS:000279530000054
PM 20171637
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Dai, YQ
   Duan, SY
   Wang, R
   He, P
   Zhang, ZY
   Li, MY
   Shen, ZH
   Chen, Y
   Zhao, Y
   Yang, HF
   Li, XY
   Zhang, R
   Sun, J
AF Dai, Yuqing
   Duan, Siyu
   Wang, Rui
   He, Pei
   Zhang, Zhongyuan
   Li, Meiyan
   Shen, Zhuoheng
   Chen, Yue
   Zhao, Yi
   Yang, Huifang
   Li, Xiaoyu
   Zhang, Rui
   Sun, Jian
TI Associations between multiple urinary metals and metabolic syndrome:
   Exploring the mediating role of liver function in Chinese
   community-dwelling elderly
SO JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
LA English
DT Article
DE Metabolic syndrome; Urinary metals; Liver function; Community-dwelling
   elderly; Mediation
ID OXIDATIVE STRESS; HEAVY-METALS; HUMAN HEALTH; RISK-FACTOR; TOXICITY;
   ZINC; COPPER; TELLURIUM; EXPOSURE
AB Background: Multiple metals exposure has been revealed to be related to metabolic syndrome (MetS). However, the associations and interactions between multiple metals exposure and MetS are remains controversial, and the potential mechanism of the above-mentioned is still unclear. Methods: The associations between urinary metals and the MetS were analyzed by multivariable logistic regression model and restricted cubic spline (RCS). Bayesian kernel machine regression (BKMR) model and quantile-based g-computation (qgcomp) were applied to explore the mixed exposure and interaction effect of metals. Mediation analysis was used to explore the role of liver function. Results: In the single metal model, multiple metals were significantly associated with MetS. RCS analysis further verified the associations between 8 metals and MetS. BKMR model and qgcomp showed that zinc (Zn), iron (Fe), and tellurium (Te) were the main factors affecting the overall effect. In addition, mediation analysis indicated that serum alanine aminotransferase (ALT) mediated 21.54% and 13.29% in the associations of vanadium (V) and Zn with the risk of MetS, respectively. Conclusions: Elevated urinary concentration of Zn, V, Te, copper (Cu), molybdenum (Mo), and thallium (Tl) were related to the increased risk of MetS. Conversely, Fe and selenium (Se) may be protective factors for MetS in mixed exposure. Liver function may play a key role in the association of V and Zn exposure with MetS.
C1 [Dai, Yuqing; Duan, Siyu; Wang, Rui; He, Pei; Zhang, Zhongyuan; Li, Meiyan; Shen, Zhuoheng; Chen, Yue; Zhao, Yi; Yang, Huifang; Li, Xiaoyu; Zhang, Rui; Sun, Jian] Ningxia Med Univ, Sch Publ Hlth, Yinchuan 750004, Ningxia, Peoples R China.
   [Zhao, Yi] Ningxia Med Univ, NHC Key Lab Metab Cardiovasc Dis Res, Yinchuan 750004, Ningxia, Peoples R China.
   [Dai, Yuqing; Duan, Siyu; Wang, Rui; He, Pei; Zhang, Zhongyuan; Li, Meiyan; Shen, Zhuoheng; Chen, Yue; Zhao, Yi; Yang, Huifang; Li, Xiaoyu; Sun, Jian] Key Lab Environm Factors & Chron Dis Control, Yinchuan 750004, Ningxia, Peoples R China.
   [Zhang, Rui] Ningxia Med Univ, Ningxia Key Lab Cerebrocranial Dis, Incubat Base Natl Key Lab, Yinchuan 750004, Ningxia, Peoples R China.
   [Li, Xiaoyu; Zhang, Rui; Sun, Jian] 1160 Shengli St, Yinchuan 750004, Peoples R China.
C3 Ningxia Medical University; Ningxia Medical University; Ningxia Medical
   University
RP Li, XY; Zhang, R; Sun, J (corresponding author), 1160 Shengli St, Yinchuan 750004, Peoples R China.
EM lxyandpp@foxmail.com; z_zhangrui@163.com; 20180016@nxmu.edu.cn
RI Dai, Yuqing/AAC-1565-2022
FU Light of the West Talent Training Plan Project of Chinese Academy of
   Sciences [XAB2022YW18]; National Natural Science Foundation of China
   [82202431]; Natural Science Foundation Project of Ningxia, China
   [2022AAC05024, 2023AAC02032, 2022AAC05028]; Key Research and Development
   Project of Ningxia [2021BEG02026, 2023BEG02028]
FX This work was supported by the "Light of the West" Talent Training Plan
   Project of Chinese Academy of Sciences (XAB2022YW18) , the National
   Natural Science Foundation of China (No.82202431) , the Natural Science
   Foundation Project of Ningxia, China (2022AAC05024, 2023AAC02032 and
   2022AAC05028) , the Key Research and Development Project of Ningxia
   (2021BEG02026) , and the Key Research and Development Project of Ningxia
   (Grant No. 2023BEG02028) .
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NR 57
TC 1
Z9 1
U1 5
U2 12
PU ELSEVIER GMBH
PI MUNICH
PA HACKERBRUCKE 6, 80335 MUNICH, GERMANY
SN 0946-672X
EI 1878-3252
J9 J TRACE ELEM MED BIO
JI J. Trace Elem. Med. Biol.
PD SEP
PY 2024
VL 85
AR 127472
DI 10.1016/j.jtemb.2024.127472
EA MAY 2024
PG 10
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA UO6U6
UT WOS:001249047000001
PM 38823271
DA 2025-06-11
ER

PT J
AU Marycz, K
   Kornicka, K
   Marezdziak, M
   Golonka, P
   Nicpon, J
AF Marycz, Krzysztof
   Kornicka, Katarzyna
   Marezdziak, Monika
   Golonka, Pawel
   Nicpon, Jakub
TI Equine metabolic syndrome impairs adipose stem cells osteogenic
   differentiation by predominance of autophagy over selective mitophagy
SO JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
LA English
DT Article
DE mitochondria; autophagy; mitophagy; mitochondria biogenesis; equine
   metabolic syndrome; adipose derived stem cells
ID INSULIN-RESISTANCE; MULTILINEAGE DIFFERENTIATION; MITOCHONDRIAL
   BIOGENESIS; DIABETES-MELLITUS; DNA METHYLATION; UMBILICAL-CORD;
   IN-VITRO; HORSES; MICROVESICLES; EXPRESSION
AB Adipose-derived mesenchymal stem cells (ASC) hold great promise in the treatment of many disorders including musculoskeletal system, cardiovascular and/or endocrine diseases. However, the cytophysiological condition of cells, used for engraftment seems to be fundamental factor that might determine the effectiveness of clinical therapy. In this study we investigated growth kinetics, senescence, accumulation of oxidative stress factors, mitochondrial biogenesis, autophagy and osteogenic differentiation potential of ASC isolated from horses suffered from equine metabolic syndrome (EMS). We demonstrated that EMS condition impairs multipotency/pluripotency in ASCs causes accumulation of reactive oxygen species and mitochondria deterioration. We found that, cytochrome c is released from mitochondria to the cytoplasm suggesting activation of intrinsic apoptotic pathway in those cells. Moreover, we observed up-regulation of p21 and decreased ratio of Bcl-2/BAX. Deteriorations in mitochondria structure caused alternations in osteogenic differentiation of ASC(EMS) resulting in their decreased proliferation rate and reduced expression of osteogenic markers BMP-2 and collagen type I. During osteogenic differentiation of ASC(EMS), we observed autophagic turnover as probably, an alternative way to generate adenosine triphosphate and amino acids required to increased protein synthesis during differentiation. Downregulation of PGC1 alpha, PARKIN and PDK4 in differentiated ASC(EMS) confirmed impairments in mitochondrial biogenesis and function. Hence, application of ASC(EMS) into endocrinological or ortophedical practice requires further investigation and analysis in the context of safeness of their application.
C1 [Marycz, Krzysztof; Kornicka, Katarzyna] Univ Environm & Life Sci Wroclaw, Fac Biol & Anim Sci, Electron Microscopy Lab, Wroclaw, Poland.
   [Marycz, Krzysztof; Kornicka, Katarzyna] Wroclaw Res Ctr EIT, Wroclaw, Poland.
   [Marezdziak, Monika] Univ Environm & Life Sci Wroclaw, Fac Vet Med, Dept Anim Physiol & Biostruct, Wroclaw, Poland.
   [Golonka, Pawel] Equine Clin Equivet, Gliwice, Poland.
   [Nicpon, Jakub] Univ Environm & Life Sci Wroclaw, Dept Surg, Fac Vet Med, Wroclaw, Poland.
C3 Wroclaw University of Environmental & Life Sciences; Wroclaw University
   of Environmental & Life Sciences; Wroclaw University of Environmental &
   Life Sciences
RP Marycz, K (corresponding author), Univ Environm & Life Sci Wroclaw, Fac Biol & Anim Sci, Electron Microscopy Lab, Wroclaw, Poland.; Marycz, K (corresponding author), Wroclaw Res Ctr EIT, Wroclaw, Poland.
EM krzysztofmarycz@interia.pl
RI Nicpoń, Jakub/A-4955-2017; Marycz, Krzysztof/A-2249-2017
OI Nicpon, Jakub/0000-0002-8168-6301
FU Wroclaw Centre of Biotechnology, programme the Leading National Research
   Centre (KNOW)
FX Publication supported by Wroclaw Centre of Biotechnology, programme the
   Leading National Research Centre (KNOW) for years 2014-2018.
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NR 84
TC 65
Z9 68
U1 0
U2 28
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1582-1838
EI 1582-4934
J9 J CELL MOL MED
JI J. Cell. Mol. Med.
PD DEC
PY 2016
VL 20
IS 12
BP 2384
EP 2404
DI 10.1111/jcmm.12932
PG 21
WC Cell Biology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Research & Experimental Medicine
GA ED8WY
UT WOS:000389152800018
PM 27629697
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Kim, B
   Kang, YT
   Mendelson, FE
   Hayes, JM
   Savelieff, MG
   Nagrath, S
   Feldman, EL
AF Kim, Bhumsoo
   Kang, Yoon-Tae
   Mendelson, Faye E.
   Hayes, John M.
   Savelieff, Masha G.
   Nagrath, Sunitha
   Feldman, Eva L.
TI Palmitate and glucose increase amyloid precursor protein in
   extracellular vesicles: Missing link between metabolic syndrome and
   Alzheimer's disease
SO JOURNAL OF EXTRACELLULAR VESICLES
LA English
DT Article
DE Alzheimer's disease; amyloid precursor protein; diabetes; extracellular
   vesicles; insulin resistance; metabolic syndrome; obesity; tau
ID INSULIN-RECEPTOR SUBSTRATE; A-BETA; TERMINAL FRAGMENTS; FATTY-ACIDS;
   MOUSE MODEL; RESISTANCE; PHOSPHORYLATION; BRAIN; DYSFUNCTION; EXOSOMES
AB The metabolic syndrome (MetS) and Alzheimer's disease share several pathological features, including insulin resistance, abnormal protein processing, mitochondrial dysfunction and elevated inflammation and oxidative stress. The MetS constitutes elevated fasting glucose, obesity, dyslipidaemia and hypertension and increases the risk of developing Alzheimer's disease, but the precise mechanism remains elusive. Insulin resistance, which develops from a diet rich in sugars and saturated fatty acids, such as palmitate, is shared by the MetS and Alzheimer's disease. Extracellular vesicles (EVs) are also a point of convergence, with altered dynamics in both the MetS and Alzheimer's disease. However, the role of palmitate- and glucose-induced insulin resistance in the brain and its potential link through EVs to Alzheimer's disease is unknown. We demonstrate that palmitate and high glucose induce insulin resistance and amyloid precursor protein phosphorylation in primary rat embryonic cortical neurons and human cortical stem cells. Palmitate also triggers insulin resistance in oligodendrocytes, the supportive glia of the brain. Palmitate and glucose enhance amyloid precursor protein secretion from cortical neurons via EVs, which induce tau phosphorylation when added to na & iuml;ve neurons. Additionally, EVs from palmitate-treated oligodendrocytes enhance insulin resistance in recipient neurons. Overall, our findings suggest a novel theory underlying the increased risk of Alzheimer's disease in MetS mediated by EVs, which spread Alzheimer's pathology and insulin resistance.
C1 [Kim, Bhumsoo; Mendelson, Faye E.; Hayes, John M.; Feldman, Eva L.] Univ Michigan, Dept Neurol, Ann Arbor, MI 48109 USA.
   [Kim, Bhumsoo; Mendelson, Faye E.; Hayes, John M.; Savelieff, Masha G.; Feldman, Eva L.] Univ Michigan, NeuroNetwork Emerging Therapies, Ann Arbor, MI 48109 USA.
   [Kang, Yoon-Tae; Nagrath, Sunitha] Univ Michigan, Dept Chem Engn, Ann Arbor, MI 48109 USA.
   [Kang, Yoon-Tae; Nagrath, Sunitha] Univ Michigan, Biointerfaces Inst, Ann Arbor, MI 48109 USA.
C3 University of Michigan System; University of Michigan; University of
   Michigan System; University of Michigan; University of Michigan System;
   University of Michigan; University of Michigan System; University of
   Michigan
RP Feldman, EL (corresponding author), Univ Michigan, Dept Neurol, Ann Arbor, MI 48109 USA.
EM efeldman@umich.edu
RI Kang, Yoon-Tae/AAL-6732-2020
OI Kim, Bhumsoo/0000-0002-2645-1673
FU Sinai Medical Staff Foundation; National Institutes of Health
   [R01DK130913, U24DK115255]; A. Alfred Taubman Medical Research
   Institute; NeuroNetwork for Emerging Therapies; Andrea and Lawrence A.
   Wolfe Brain Health Initiative Fund; Robert E. Nederlander Sr. Program
   for Alzheimer's Research; Michigan Diabetes Research Center for the
   confocal imaging to Michigan Diabetes Research Center for the confocal
   imaging [P30DK02572]; National Institute of Diabetes and Digestive and
   Kidney Diseases [R01DK130913] Funding Source: NIH RePORTER
FX Sinai Medical Staff Foundation; National Institutes of Health,
   Grant/Award Numbers: R01DK130913, U24DK115255; A. Alfred Taubman Medical
   Research Institute; NeuroNetwork for Emerging Therapies; Andrea and
   Lawrence A. Wolfe Brain Health Initiative Fund; Robert E. Nederlander
   Sr. Program for Alzheimer's Research; Michigan Diabetes Research Center
   for the confocal imaging to Michigan Diabetes Research Center for the
   confocal imaging, Grant/Award Number: P30DK02572
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NR 97
TC 9
Z9 9
U1 0
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
EI 2001-3078
J9 J EXTRACELL VESICLES
JI J. Extracell. Vesicles
PD NOV
PY 2023
VL 12
IS 11
AR e12340
DI 10.1002/jev2.12340
PG 16
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA W4ZM1
UT WOS:001091724500001
PM 37898562
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU D'Alonzo, KT
   Garsman, L
AF D'Alonzo, Karen T.
   Garsman, Lisa
TI The Impact of Childhood Growth Stunting and Post-Migration Dysbiosis on
   the Development of Metabolic Syndrome Among Indigenous Immigrant Mexican
   Women
SO BIOLOGICAL RESEARCH FOR NURSING
LA English
DT Article
DE metabolic syndrome; childhood growth stunting; dysbiosis; immigrant
   health
ID RISK-FACTORS; EARLY-LIFE; ENVIRONMENTAL ENTEROPATHY; GUT MICROBIOTA;
   CARDIOVASCULAR-DISEASE; INTESTINAL MICROBIOTA; PREVALENCE; STRESS;
   HEALTH; NUTRITION
AB While weight gain is common following migration to a new country and Mexican Americans have a disparate prevalence of overweight and obesity. In particular, Mexican American women have one of the world's highest rates of Metabolic Syndrome (MetS), characterized by abdominal obesity, insulin resistance, hypertension, and dyslipidemia, all of which increase the risk for atherosclerotic cardiovascular disease (CVD). Although the etiology of this dilemma is not well understood, using the framework of allostatic load (AL), we posit that exposure to multiple physiologic, psychosocial and environmental stressors over the course of the lifespan may contribute to an increased risk of MetS among indigenous Mexican immigrant women. Two such frequently overlooked stressors are: 1) a history of childhood growth stunting (CGS) and 2) dietary changes post migration that result in decreased diversity of the gut microbiome (dysbiosis). To date, little is known about how migration experiences differentially affect the relationship between CGS and MetS in adulthood. The purpose of this theoretical article is to present a proposed model of how early life stressors (ELS), specifically CGS, may interact with insalubrious aspects of the immigration experience to promote an increased risk for MetS among indigenous Mexican immigrant women. This model may be used in a bi-national effort to guide intervention efforts to decrease CGS in Mexico and to prevent, monitor or delay the components of MetS post migration in the US.
C1 [D'Alonzo, Karen T.] Rutgers State Univ, Sch Nursing, Newark, NJ USA.
   [Garsman, Lisa] St Peters Univ, Sch Nursing, Jersey City, NJ USA.
C3 Rutgers University System; Rutgers University Newark; Rutgers University
   New Brunswick
RP D'Alonzo, KT (corresponding author), Rutgers State Univ, Sch Nursing, 110 Paterson St, New Brunswick, NJ 08901 USA.
EM kdalonzo@rutgers.edu
RI D'Alonzo, Karen/GSM-6563-2022
OI Garsman, Lisa/0000-0001-6598-255X
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NR 77
TC 2
Z9 2
U1 2
U2 9
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1099-8004
EI 1552-4175
J9 BIOL RES NURS
JI Biol. Res. Nurs.
PD OCT
PY 2020
VL 22
IS 4
SI SI
BP 552
EP 560
AR 1099800420941599
DI 10.1177/1099800420941599
EA JUL 2020
PG 9
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA NV8BS
UT WOS:000548874500001
PM 32666821
DA 2025-06-11
ER

PT J
AU Patruno, I
   Thompson, D
   Dall'Angelo, S
   Windhorst, AD
   Vugts, DJ
   Poot, AJ
   Mody, N
   Zanda, M
AF Patruno, Ilaria
   Thompson, Dawn
   Dall'Angelo, Sergio
   Windhorst, Albert D.
   Vugts, Danielle J.
   Poot, Alex J.
   Mody, Nimesh
   Zanda, Matteo
TI Design, Synthesis, Radiosynthesis and Biological Evaluation of
   Fenretinide Analogues as Anticancer and Metabolic Syndrome-Preventive
   Agents
SO CHEMMEDCHEM
LA English
DT Article
DE cancer; drug discovery; fenretinide; metabolic syndrome;
   radiopharmaceuticals
ID DIET-INDUCED OBESITY; DIHYDROCERAMIDE DESATURASE; HIGH-FAT; SPHINGOSINE
   KINASE; APOPTOSIS; N-(4-HYDROXYPHENYL)RETINAMIDE; STRESS; PET;
   DIFFERENTIATION; DERIVATIVES
AB Fenretinide (4-HPR) is a synthetic derivative of all-trans-retinoic acid (ATRA) characterised by improved therapeutic properties and toxicological profile relative to ATRA. 4-HPR has been mostly investigated as an anti-cancer agent, but recent studies showed its promising therapeutic potential for preventing metabolic syndrome. Several biological targets are involved in 4-HPR's activity, leading to the potential use of this molecule for treating different pathologies. However, although 4-HPR displays quite well-understood multitarget promiscuity with regards to pharmacology, interpreting its precise physiological role remains challenging. In addition, despite promising resultsin vitro, the clinical efficacy of 4-HPR as a chemotherapeutic agent has not been satisfactory so far. Herein, we describe the preparation of a library of 4-HPR analogues, followed by the biological evaluation of their anti-cancer and anti-obesity/diabetic properties. The click-type analogue3 bshowed good capacity to reduce the amount of lipid accumulation in 3T3-L1 adipocytes during differentiation. Furthermore, it showed an IC(50)of 0.53 +/- 0.8 mu M in cell viability tests on breast cancer cell line MCF-7, together with a good selectivity (SI=121) over noncancerous HEK293 cells. Thus,3 bwas selected as a potential PET tracer to study retinoidsin vivo, and the radiosynthesis of [F-18]3bwas successfully developed. Unfortunately, the stability of [F-18]3bturned out to be insufficient to pursue imaging studies.
C1 [Patruno, Ilaria; Thompson, Dawn; Dall'Angelo, Sergio; Mody, Nimesh; Zanda, Matteo] Univ Aberdeen, Inst Med Sci, Aberdeen AB25 2ZD, Scotland.
   [Windhorst, Albert D.; Vugts, Danielle J.; Poot, Alex J.] Vrije Univ Amsterdam Med Ctr, Canc Ctr Amsterdam, Amsterdam UMC, De Boelelaan 1117, NL-1081 HV Amsterdam, Netherlands.
   [Zanda, Matteo] CNR SCITEC, Via Mancinelli 7, I-20131 Milan, Italy.
   [Zanda, Matteo] Loughborough Univ, Sch Sci, Ctr Sensing & Imaging Sci, Sir David Davies Bldg, Loughborough LE11 3TU, Leics, England.
C3 University of Aberdeen; Vrije Universiteit Amsterdam; VU UNIVERSITY
   MEDICAL CENTER; Consiglio Nazionale delle Ricerche (CNR); Istituto di
   Scienze Tecnologie Chimiche "Giulio Natta" (SCITEC-CNR); Loughborough
   University
RP Mody, N; Zanda, M (corresponding author), Univ Aberdeen, Inst Med Sci, Aberdeen AB25 2ZD, Scotland.; Zanda, M (corresponding author), CNR SCITEC, Via Mancinelli 7, I-20131 Milan, Italy.; Zanda, M (corresponding author), Loughborough Univ, Sch Sci, Ctr Sensing & Imaging Sci, Sir David Davies Bldg, Loughborough LE11 3TU, Leics, England.
EM n.mody@abdn.ac.uk; m.zanda@lboro.ac.uk
RI Vercouillie, Johnny/K-8938-2014; Mody, Nimesh/J-9602-2019; Zanda,
   Matteo/AAC-2391-2022; Dall'Angelo, Sergio/J-5333-2014
OI Mody, Nimesh/0000-0002-2215-7952; Dall'Angelo,
   Sergio/0000-0001-9377-0474; Windhorst, Albert/0000-0002-1250-7656
FU European Union [675417]; British Heart Foundation [PG/16/90/32518];
   Marie Curie Actions (MSCA) [675417] Funding Source: Marie Curie Actions
   (MSCA)
FX We thank the European Union's Horizon 2020 research and innovation
   programme under the Marie Skodowska-Curie grant agreement no. 675417
   (PET3D project) for financial support of the project and the studentship
   of I.P. We also thank the British Heart Foundation for the project grant
   PG/16/90/32518.
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NR 44
TC 2
Z9 2
U1 0
U2 11
PU WILEY-V C H VERLAG GMBH
PI WEINHEIM
PA POSTFACH 101161, 69451 WEINHEIM, GERMANY
SN 1860-7179
EI 1860-7187
J9 CHEMMEDCHEM
JI ChemMedChem
PD AUG 19
PY 2020
VL 15
IS 16
BP 1579
EP 1590
DI 10.1002/cmdc.202000143
EA JUL 2020
PG 12
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED); Index Chemicus (IC)
SC Pharmacology & Pharmacy
GA NC4SI
UT WOS:000546405300001
PM 32497314
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Meikle, PJ
   Wong, G
   Tan, R
   Giral, P
   Robillard, P
   Orsoni, A
   Hounslow, N
   Magliano, DJ
   Shaw, JE
   Curran, JE
   Blangero, J
   Kingwell, BA
   Chapman, MJ
AF Meikle, Peter J.
   Wong, Gerard
   Tan, Ricardo
   Giral, Philippe
   Robillard, Paul
   Orsoni, Alexina
   Hounslow, Neil
   Magliano, Dianna J.
   Shaw, Jonathan E.
   Curran, Joanne E.
   Blangero, John
   Kingwell, Bronwyn A.
   Chapman, M. John
TI Statin action favors normalization of the plasma lipidome in the
   atherogenic mixed dyslipidemia of MetS: potential relevance to
   statin-associated dysglycemia
SO JOURNAL OF LIPID RESEARCH
LA English
DT Article
DE lipidomics; obesity; plasmalogens; cholesterol; omega-3 fatty acids;
   pitavastatin; metabolic syndrome
ID DENSITY-LIPOPROTEIN; INSULIN-RESISTANCE; CARDIOVASCULAR-DISEASE;
   METABOLIC SYNDROME; DIABETES-MELLITUS; OXIDATIVE STRESS;
   CLINICAL-TRIALS; RISK-FACTORS; CHOLESTEROL; THERAPY
AB The impact of statin treatment on the abnormal plasma lipidome of mixed dyslipidemic patients with metabolic syndrome (MetS), a group at increased risk of developing diabetes, was evaluated. Insulin-resistant hypertriglyceridemic hypertensive obese males (n = 12) displaying MetS were treated with pitavastatin (4 mg/day) for 180 days; healthy normolipidemic age-matched nonobese males (n = 12) acted as controls. Statin treatment substantially normalized triglyceride (-41%), remnant cholesterol (-55%), and LDL-cholesterol (-39%), with minor effect on HDL-cholesterol (+4%). Lipidomic analysis, normalized to nonHDL-cholesterol in order to probe statin-induced differences in molecular composition independently of reduction in plasma cholesterol, revealed increment in 132 of 138 lipid species that were subnormal at baseline and significantly shifted toward the control group on statin treatment. Increment in alkyl- and alkenylphospholipids (plasmalogens) was prominent, and consistent with significant statin-induced increase in plasma polyunsaturated fatty acid levels. Comparison of the statin-mediated lipidomic changes in MetS with the abnormal plasma lipidomic profile characteristic of prediabetes and T2D in the Australian Diabetes, Obesity, and Lifestyle Study and San Antonio Family Heart Study cohorts by hypergeometric analysis revealed a significant shift toward the lipid profile of controls, indicative of a marked trend toward a normolipidemic phenotype. Pitavastatin attenuated the abnormal plasma lipidome of MetS patients typical of prediabetes and T2D.
C1 [Meikle, Peter J.; Wong, Gerard; Tan, Ricardo; Magliano, Dianna J.; Shaw, Jonathan E.; Kingwell, Bronwyn A.] Baker IDI Heart & Diabet Inst, Melbourne, Vic, Australia.
   [Giral, Philippe; Robillard, Paul; Orsoni, Alexina; Chapman, M. John] Pitie Salpetriere Univ Hosp, Dyslipidemia & Atherosclerosis Res Unit, INSERM UMR S939, Paris, France.
   [Giral, Philippe; Robillard, Paul; Orsoni, Alexina; Chapman, M. John] Univ Paris 06, Pitie Salpetriere Univ Hosp, Paris, France.
   [Hounslow, Neil] Kowa Res Europe Ltd, Wokingham, Berks, England.
   [Curran, Joanne E.; Blangero, John] Univ Texas Hlth Sci Ctr San Antonio, South Texas Diabet & Obes Inst, Harlingen, TX USA.
C3 Baker Heart and Diabetes Institute; Institut National de la Sante et de
   la Recherche Medicale (Inserm); Sorbonne Universite; Assistance Publique
   Hopitaux Paris (APHP); Hopital Universitaire Pitie-Salpetriere - APHP;
   Assistance Publique Hopitaux Paris (APHP); Hopital Universitaire
   Pitie-Salpetriere - APHP; Sorbonne Universite; University of Texas
   System; University of Texas Health Science Center at San Antonio
RP Meikle, PJ (corresponding author), Baker IDI Heart & Diabet Inst, Melbourne, Vic, Australia.
EM peter.meikle@bakeridi.edu.au
RI Blangero, John/ABA-7175-2021; Hounslow, Neil/GQA-9028-2022; Meikle,
   Peter/B-4023-2009; chapman, john/Y-2742-2019; Kingwell,
   Bronwyn/B-1183-2009; ORSONI, Alexina/C-6740-2009
OI ORSONI, Alexina/0000-0003-4250-6280; Kingwell,
   Bronwyn/0000-0002-2162-0458; Hounslow, Neil/0000-0002-9821-4941; Curran,
   Joanne/0000-0002-6898-155X; Magliano, Dianna/0000-0002-9507-6096;
   Meikle, Peter/0000-0002-2593-4665; Blangero, John/0000-0001-6250-5723
FU Kowa Research Europe; INSERM; Nouvelle Societe Francaise
   d'Atherosclerose (NSFA); Association for Research on Lipoproteins and
   Atherogenesis (ARLA); National Health and Medical Research Council of
   Australia; OIS Program of the Victorian Government, Australia; National
   Institute of Diabetes and Digestive and Kidney Diseases, National
   Institutes of Health, Bethesda, MD [1R01DK088972-01]; NHMRC Senior
   Research Fellowships; NHMRC Senior Principal Research Fellowship
FX The authors are indebted to Kowa Research Europe for the award of a
   clinical research grant to support all aspects of the CAPITAIN study and
   lipidomic analyses (ClinicalTrials.gov: NCT01595828), and to INSERM, the
   Nouvelle Societe Francaise d'Atherosclerose (NSFA), and the Association
   for Research on Lipoproteins and Atherogenesis (ARLA) for additional
   support. This work was equally supported by funding from the National
   Health and Medical Research Council of Australia, the OIS Program of the
   Victorian Government, Australia, and by award number 1R01DK088972-01
   from the National Institute of Diabetes and Digestive and Kidney
   Diseases, National Institutes of Health, Bethesda, MD. P.J.M. and J.E.S.
   are supported by NHMRC Senior Research Fellowships and B.A.K. by a NHMRC
   Senior Principal Research Fellowship. The content of this work is solely
   the responsibility of the authors and does not necessarily represent the
   official views of the aforementioned funding bodies. The authors take
   full responsibility for the content of this manuscript.
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NR 41
TC 46
Z9 48
U1 1
U2 14
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0022-2275
EI 1539-7262
J9 J LIPID RES
JI J. Lipid Res.
PD DEC
PY 2015
VL 56
IS 12
BP 2381
EP 2392
DI 10.1194/jlr.P061143
PG 12
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA CX6XA
UT WOS:000365843800014
PM 26486974
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Siqueira, FJWS
   Rodrigues, FAP
   Ribeiro, SA
   Veras, HN
   Ferreira, FCS
   Siqueira, RCL
   dos Santos, AA
   Havt, A
   Lima, AAM
AF Siqueira, F. J. W. S.
   Rodrigues, F. A. P.
   Ribeiro, S. A.
   Veras, H. N.
   Ferreira, F. C. S.
   Siqueira, R. C. L.
   dos Santos, A. A.
   Havt, A.
   Lima, A. A. M.
TI Induced acute hyperglycemia modifies the barrier function of the
   intestinal epithelium by tissue inflammation and tight junction
   disruption resulting in hydroelectrolytic secretion in an animal model
SO BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
LA English
DT Article
DE Diabetic metabolic syndrome; Intestinal epithelium barrier function;
   Tight junctions; Oxidative damage; Ion and; water intestinal transports
ID METABOLIC SYNDROME; TRANSPORT; CHILDREN
AB Diabetic-metabolic syndrome (MetS-D) has a high prevalence worldwide, in which an association with the rupture of the intestinal epithelium barrier function (IEBF) has been pointed out, but the functional and morphological properties are still not well understood. This study aimed to evaluate the impact of acute hyperglycemia diabetes on intestinal tight junction proteins, metabolic failure, intestinal ion and water transports, and IEBF parameters. Diabetes was induced in male Rattus norvegicus (200-310 g) with 0.5 mL of streptozotocin (70 mg/kg). Glycemic and clinical parameters were evaluated every 7 days, and intestinal parameters were evaluated on the 14th day. The MetS-D animals showed a clinical pattern of hyperglycemia, with increases in the area of villi and crypts, lactulose:mannitol ratio, myeloperoxidase (MPO) activity, and intestinal tissue concentrations of malondialdehyde (MDA), but showed a reduction in reduced glutathione (GSH) when these parameters were compared to the control. The MetS-D group had increased secretion of Na+, K+, Cl-, and water compared to the control group in ileal tissue. Furthermore, we observed a reduction in mRNA transcript of claudin-2, claudin-15, and NHE3 and increases of SGLT-1 and ZO-1 in the MetS-D group. These results showed that MetS-D triggered intestinal tissue inflammation, oxidative stress, complex alterations in gene regulatory protein transcriptions of intestinal transporters and tight junctions, damaging the IEBF and causing hydroelectrolyte secretion.
C1 [Siqueira, F. J. W. S.; Veras, H. N.; Ferreira, F. C. S.; Siqueira, R. C. L.; dos Santos, A. A.; Havt, A.; Lima, A. A. M.] Univ Fed Ceara, Fac Med, Dept Fisiol & Farmacol, Fortaleza, CE, Brazil.
   [Rodrigues, F. A. P.] Inst Fed Educ Ciencia & Tecnol Ceara, Dept Educ Fis & Esporte, Fortaleza, CE, Brazil.
   [Ribeiro, S. A.] Univ Fed Ceara, Fac Med, Dept Patol & Med Legal, Programa Posgrad Ciencias Med, Fortaleza, CE, Brazil.
C3 Universidade Federal do Ceara; Instituto Federal do Ceara (IFCE);
   Universidade Federal do Ceara
RP Lima, AAM (corresponding author), Univ Fed Ceara, Fac Med, Dept Fisiol & Farmacol, Fortaleza, CE, Brazil.
EM alima@ufc.br
RI de Paulo Rodrigues, Francisco/ABI-3860-2020; Havt,
   Alexandre/AAM-8585-2020; LIMA, ALDO/D-8251-2018
OI Havt, Alexandre/0000-0002-4546-2976; Rodrigues, Francisco Adelvane de
   Paulo/0000-0001-9890-4232; LIMA, ALDO/0000-0002-0299-1747; Silva
   Ferreira, Francisco Cleber/0000-0002-9501-870X; Aguiar dos Santos,
   Armenio/0000-0003-0912-3720; SIQUEIRA, ROMMULO CELLY
   LIMA/0000-0003-0533-9305
FU National Council for Scientific and Technological Development (CNPq);
   Coordination for the Improvement of Higher Education Personnel (CAPES);
   Cearense Foundation for Scientific and Technological Development
   (FUNCAp) [03041300/2021]
FX We thank the funding agencies National Council for Scientific and
   Technological Development (CNPq) , Coordination for the Improvement of
   Higher Education Personnel (CAPES) , and Cearense Foundation for
   Scientific and Technological Development (FUNCAp, No. 03041300/2021) .
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NR 40
TC 2
Z9 2
U1 3
U2 3
PU ASSOC BRAS DIVULG CIENTIFICA
PI RIBEIRAO PRETO
PA FACULDADE MEDICINA, CASA 10, 14049 RIBEIRAO PRETO, RIBEIRAO PRETO, SP
   14049, BRAZIL
SN 0100-879X
EI 1414-431X
J9 BRAZ J MED BIOL RES
JI Brazilian J. Med. Biol. Res.
PY 2024
VL 57
AR e13309
DI 10.1590/1414-431X2024e13309
PG 13
WC Biology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics; Research & Experimental
   Medicine
GA PZ3V8
UT WOS:001217870200001
PM 38656073
OA gold
DA 2025-06-11
ER

PT J
AU Mahjoub, SK
   Ahmad, MAAS
   Kamel, FO
   Alseini, M
   Khan, LM
AF Mahjoub, S. K.
   Ahmad, M. A. A. Sattar
   Kamel, F. O.
   Alseini, M.
   Khan, L. M.
TI Preclinical study of vitamin D deficiency in the pathogenesis of
   metabolic syndrome in rats
SO EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
LA English
DT Article
DE Vitamin D deficiency; Metabolic syndrome; Interleuk-ine; Homeostasis
   model assessment for insulin resistance index; Nuclear factor kappa beta
ID CARDIOVASCULAR-DISEASE; INSULIN-RESISTANCE; INDUCED HYPERTENSION;
   OXIDATIVE STRESS; RISK; ASSOCIATION; CALCIUM; GLUCOSE; OBESITY; ALPHA
AB OBJECTIVE: To explore the im-pact of vitamin D deficiency (VD-) in the patho-genesis of metabolic syndrome (MetS). MATERIALS AND METHODS: Models of (VD-) and (MetS) were induced in male Wister rats by dividing into four groups, group-I for the develop-ment of (VD-) by intraperitoneal injection of pari-calcitol for 3 weeks, group II for (MetS) model by adding 10% fructose to their drinking water for 8 weeks, the group III for induction of combined (VD-+ MetS) and group-IV as a control. Ultimately, the parameters of (VD-) and (MetS) were assessed at zero time and after 8 weeks. RESULTS: Both (VD-) and (MetS) groups alone displayed a remarkable enhancement of blood pressure, glucose and insulin levels, tri-glycerides, cholesterol, and low-density lipopro-teins with a reduction of high-density lipopro-teins. Additionally, all distinguishing features of obesity were substantially increased. Neverthe-less, the combined group (VD-+MetS) demon-strated an expeditious and substantial increase in all the aforesaid parameters compared to the (VD-) and (MetS) groups alone. CONCLUSIONS: The hallmark of this study, reinforces a new frontier of awareness of the deleterious effect of (VD-) on each component of (MetS). Eventually, supplementation of vita-min D can circumvent the elements of (MetS) and needs further validation by determination of (VD-) molecular pathway on the parameters of (MetS).
C1 [Mahjoub, S. K.] King Fahad Gen Hosp, Minist Hlth, Jeddah, Saudi Arabia.
   [Ahmad, M. A. A. Sattar; Kamel, F. O.; Alseini, M.; Khan, L. M.] King Abdulaziz Univ, Fac Med, Dept Pharmacol, Jeddah, Saudi Arabia.
C3 Ministry of Health - Saudi Arabia; King Fahd Hospital Jeddah; King
   Abdulaziz University
RP Khan, LM (corresponding author), King Abdulaziz Univ, Fac Med, Dept Pharmacol, Jeddah, Saudi Arabia.
EM lmkhan@kau.edu.sa
RI Kamel, Fatemah/HLH-3014-2023; Khan, Lateef/J-7827-2012
OI Khan, Lateef/0000-0002-3728-7717
FU King Abdulaziz City for Science and Technology [IT-1979-38]
FX Thanks to King Abdulaziz City for Science and Technology for its
   financial support for the project of the research number (IT-1979-38).
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NR 58
TC 1
Z9 1
U1 0
U2 1
PU VERDUCI PUBLISHER
PI ROME
PA VIA GREGORIO VII, ROME, 186-00165, ITALY
SN 1128-3602
J9 EUR REV MED PHARMACO
JI Eur. Rev. Med. Pharmacol. Sci.
PY 2022
VL 26
IS 23
BP 9001
EP 9014
PG 14
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 9M9VM
UT WOS:000942569200014
PM 36524519
DA 2025-06-11
ER

PT J
AU Anand, C
   Singh, R
   Narayana, S
AF Anand, Chandrika
   Singh, Rakhi
   Narayana, S.
TI Assessment of metabolic risk among the Rotterdam's polycystic ovary
   syndrome phenotypes in Bangalore
SO JOURNAL OF KRISHNA INSTITUTE OF MEDICAL SCIENCES UNIVERSITY
LA English
DT Article
DE Polycystic Ovary Syndrome; Phenotypes; Metabolic syndrome;
   Hyperandrogenism; Irregular; menstruation
ID WOMEN; PROFILE
AB Background: Polycystic Ovary Syndrome (PCOS) is characterized by a variety of complex manifestations with an unclear underlying cause. This condition is consistently linked to an increased cardio-metabolic risk. It is essential to evaluate this risk at the phenotype level to identify the most vulnerable subgroup within the PCOS population. Aim and Objectives: To phenotype the PCOS patients as per the standard Rotterdam's criteria and to assess the metabolic syndrome markers in those phenotypes. Material and Methods: A total of seven hundred participants (n=700) were assessed and categorized based on the Rotterdam criteria. Clinical, radiological, and biochemical assessments were conducted and analyzed statistically. Chi-square and two-way ANOVA tests were conducted using SPSS version 19 statistical software. The results indicated that phenotype A was the most prevalent, comprising 83.2% (583) of the cases, followed by phenotype C at 8% (56), phenotype D at 5.55% (39), and phenotype B at 3.1% (22). Notably, phenotype B, while being the least prevalent, exhibited the highest metabolic risk. This phenotype was significantly associated with increased levels of hirsutism, postprandial hyperinsulinemia, impaired glucose tolerance, and hormonal imbalances. Additionally, although not statistically significant, there was a higher occurrence of family history of metabolic syndrome, elevated waist circumference (greater than 35 inches), obesity, stress, and dyslipidemia associated with this phenotype. Conclusion: The highest metabolic risk was observed in phenotype B, which was characterized by a combination of hyperandrogenism and irregular menstruation in the absence of polycystic ovaries.
C1 [Anand, Chandrika] PCOS Ctr, Dept Gynecol & Obstet, Saraswathi Special Clin, Bangalore 560072, Karnataka, India.
   [Singh, Rakhi] Abalone Clin, Dept Gynecol & Obstet, Matern & Fertil Ctr, Noida 201301, Uttar Pradesh, India.
   [Narayana, S.] Padmashree Inst Med Lab Technol, Dept Biochem, Bangalore 560060, Karnataka, India.
RP Narayana, S (corresponding author), Padmashree Inst Med Lab Technol, Dept Biochem, Bangalore 560060, Karnataka, India.
EM narayan.s201991@gmail.com
CR AbdulAzeez IM, 2018, J KRISHNA INST MED S, V7, P62
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NR 30
TC 0
Z9 0
U1 0
U2 0
PU KRISHNA INST MEDICAL SCIENCES UNIV
PI MAHARASHTRA
PA MALKAPUR, KARAD, MAHARASHTRA, 415 539, INDIA
SN 2231-4261
J9 J KRISHNA INST MED S
JI J. Krishna Inst. Med. Sci. Univ.
PD OCT-DEC
PY 2024
VL 13
IS 4
BP 159
EP 167
PG 9
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA 1ID0Z
UT WOS:001465574100016
DA 2025-06-11
ER

PT J
AU Grzesiak, K
   Ryl, A
   Stachowska, E
   Slojewski, M
   Rotter, I
   Ratajczak, W
   Sipak, O
   Piasecka, M
   Dolegowska, B
   Laszczynska, M
AF Grzesiak, Katarzyna
   Ryl, Aleksandra
   Stachowska, Ewa
   Slojewski, Marcin
   Rotter, Iwona
   Ratajczak, Weronika
   Sipak, Olimpia
   Piasecka, Malgorzata
   Dolegowska, Barbara
   Laszczynska, Maria
TI The Relationship between Eicosanoid Levels and Serum Levels of Metabolic
   and Hormonal Parameters Depending on the Presence of Metabolic Syndrome
   in Patients with Benign Prostatic Hyperplasia
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Article
DE metabolic syndrome; benign prostatic hyperplasia; fatty acids
ID ARACHIDONIC-ACID; HYDROXYOCTADECADIENOIC ACIDS; OXIDATIVE STRESS;
   ADIPOSE-TISSUE; LINOLEIC-ACID; FATTY-ACIDS; CANCER; ASSOCIATION;
   EXPRESSION; 12-LIPOXYGENASE
AB Background: The purpose of our investigation was to analyze the relationship between the serum levels of inflammatory mediators (HETE, HODE) and the levels of selected metabolic and hormonal parameters in patients with benign prostatic hyperplasia (BPH) with regard to concomitant metabolic syndrome (MetS). Methods: The study involved 151 men with BPH. Blood samples were taken for laboratory analysis of the serum levels of metabolic and hormonal parameters. Gas chromatography was performed using an Agilent Technologies 7890A GC System. Results: We found that waist circumference was the only parameter related to the levels of fatty acids, namely: 13(S)-HODE, 9(S)-HODE, 15(S)-HETE, 12(S)-HETE, and 5-HETE. In the patients with BPH and MetS, triglycerides correlated with 9(S)-HODE, 15(S)-HETE, 12(S)-HETE, and 5-HETE, which was not observed in the patients without MetS. Similarly, total cholesterol correlated with 9(S)-HODE, and 15(S)-HETE in the patients with BPH and MetS, but not in those without MetS. In the group of BPH patients with MetS, total testosterone positively correlated with 13(S)-HODE, and free testosterone with 9(S)-HODE. Conclusions: Based on this study, it can be concluded that lipid mediators of inflammation can influence the levels of biochemical and hormonal parameters, depending on the presence of MetS in BPH patients.
C1 [Grzesiak, Katarzyna; Ratajczak, Weronika; Piasecka, Malgorzata; Laszczynska, Maria] Pomeranian Med Univ, Dept Histol & Dev Biol, Zolnierska 48, PL-71210 Szczecin, Poland.
   [Ryl, Aleksandra; Rotter, Iwona] Pomeranian Med Univ, Dept Med Rehabil & Clin Physiotherapy, Zolnierska 48, PL-71210 Szczecin, Poland.
   [Stachowska, Ewa] Pomeranian Med Univ, Dept Biochem & Human Nutr, Broniewskiego 24, PL-71460 Szczecin, Poland.
   [Slojewski, Marcin] Pomeranian Med Univ, Dept Urol & Urol Oncol, Powstancow Wlkp 72, PL-70111 Szczecin, Poland.
   [Sipak, Olimpia] Pomeranian Med Univ, Dept Obstet & Pathol Pregnancy, Zolnierska 48, PL-71210 Szczecin, Poland.
   [Dolegowska, Barbara] Pomeranian Med Univ, Dept Microbiol Immunol & Lab Med, Powstancow Wlkp 72, PL-70111 Szczecin, Poland.
C3 Pomeranian Medical University; Pomeranian Medical University; Pomeranian
   Medical University; Pomeranian Medical University; Pomeranian Medical
   University; Pomeranian Medical University
RP Ryl, A (corresponding author), Pomeranian Med Univ, Dept Med Rehabil & Clin Physiotherapy, Zolnierska 48, PL-71210 Szczecin, Poland.
EM kasia.grzesiak302@gmail.com; aleksandra.ryl@pum.edu.pl;
   ewast@pum.edu.pl; mslojewski@gmail.com; iwrot@wp.pl;
   veronica.ratajczak@gmail.com; olimpiasipak-szmigiel@wp.pl;
   mpiasecka@ipartner.com.pl; barbara.dolegowska@pum.edu.pl;
   maria@laszczynska.pl
RI Sipak-Szmigiel, Olimpia/A-5562-2016; Slojewski, Marcin/P-6992-2014;
   Stachowska, Ewa/G-9521-2017; Dolegowska, Barbara/O-4851-2014; Ratajczak,
   Weronika/K-5821-2018; Rotter, Iwona/O-6539-2014; Ryl,
   Aleksandra/L-6760-2015; Laszczynska, Maria/O-7371-2014; Piasecka,
   Malgorzata/A-9894-2015
OI Stachowska, Ewa/0000-0002-4009-1977; Dolegowska,
   Barbara/0000-0003-3138-1013; Ratajczak, Weronika/0000-0002-8397-9757;
   Rotter, Iwona/0000-0002-4337-6476; Ryl, Aleksandra/0000-0002-5954-4489;
   Grzesiak, Katarzyna/0000-0003-2246-5549; Laszczynska,
   Maria/0000-0002-1580-1885; Sipak-Szmigiel, Olimpia/0000-0002-3410-1809;
   Slojewski, Marcin/0000-0003-3679-7325; Piasecka,
   Malgorzata/0000-0002-5914-2121
FU Pomeranian Medical University [WNoZ-322-02/S/17/2018]
FX The research was financed by Pomeranian Medical University grant number
   WNoZ-322-02/S/17/2018.
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NR 47
TC 3
Z9 3
U1 1
U2 11
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-7827
EI 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD MAR 2
PY 2019
VL 16
IS 6
AR 1006
DI 10.3390/ijerph16061006
PG 11
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA HU3GB
UT WOS:000465159500106
PM 30897712
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Teng, CF
   Hsieh, WC
   Yang, CW
   Su, HM
   Tsai, TF
   Sung, WC
   Huang, WY
   Su, IJ
AF Teng, Chiao-Fang
   Hsieh, Wen-Chuan
   Yang, Ching-Wen
   Su, Hui-Min
   Tsai, Ting-Fen
   Sung, Wang-Chou
   Huang, Wenya
   Su, Ih-Jen
TI A Biphasic Response Pattern of Lipid Metabolomics in the Stage
   Progression of Hepatitis B Virus X Tumorigenesis
SO MOLECULAR CARCINOGENESIS
LA English
DT Article
DE metabolic syndrome; hepatocellular carcinoma; triglycerides;
   cholesterol; fatty acids
ID GROUND-GLASS HEPATOCYTES; PROTEIN TRANSGENIC MICE; PRIMARY LIVER-CANCER;
   HEPATOCELLULAR-CARCINOMA; FATTY LIVER; MOUSE MODEL; PATHOGENESIS;
   METABOLISM; EXPRESSION; MTOR
AB Metabolic syndrome has closely linked to the development of human hepatocellular carcinoma (HCC). By using the hepatitis B virus (HBV) X (HBx) transgenic mouse model, we studied the dynamic evolution of serum and liver profiles of lipids and global cDNA expression at different stages of HBx tumorigenesis. We observed that the lipid (triglycerides, cholesterol, and fatty acids) profiles revealed a biphasic response pattern during the progression of HBx tumorigenesis: a small peak at early phase and a large peak or terminal switch at the tumor phase. By analyzing cDNA microarray data, the early peak correlated to the oxidative stress and pro-inflammatory response, which then resolved at the middle phase and were followed by the terminal metabolic switch in the tumor tissues. Five lipid metabolism-related genes, the arachidonate 5-lipoxygenase, lipoprotein lipase, fatty acid binding protein 4, 1-acylglycerol-3-phosphate O-acyltransferase 9, and apolipoprotein A-IV were identified to be significantly activated in HBx transgenic HCCs and further validated in human HBV-related HCCs. Inhibition of these lipid genes could reverse the effect of HBx on lipid biosynthesis and suppress HBx-induced cell proliferation in vitro. Our results support the concept that metabolic syndrome plays an important role in HBV tumorigenesis. The dysregulation of lipid metabolic genes may predict the disease progression to HCC in chronic hepatitis B patients. (C) 2015 Wiley Periodicals, Inc.
C1 [Teng, Chiao-Fang; Hsieh, Wen-Chuan; Sung, Wang-Chou; Su, Ih-Jen] Natl Hlth Res Inst, Natl Inst Infect Dis & Vaccinol, 367 Sheng Li Rd, Tainan 704, Taiwan.
   [Yang, Ching-Wen; Su, Ih-Jen] Natl Cheng Kung Univ, Coll Med, Inst Basic Med Res, Tainan 70101, Taiwan.
   [Su, Hui-Min] Natl Taiwan Univ, Coll Med, Dept Physiol, Taipei 10764, Taiwan.
   [Tsai, Ting-Fen] Natl Yang Ming Univ, Dept Life Sci, Taipei 112, Taiwan.
   [Tsai, Ting-Fen] Natl Yang Ming Univ, Inst Genome Sci, Taipei 112, Taiwan.
   [Tsai, Ting-Fen] Natl Hlth Res Inst, Inst Mol & Genom Med, Zhunan, Taiwan.
   [Huang, Wenya] Natl Cheng Kung Univ, Coll Med, Dept Med Lab Sci & Biotechnol, Tainan 70101, Taiwan.
C3 National Health Research Institutes - Taiwan; National Cheng Kung
   University; National Taiwan University; National Yang Ming Chiao Tung
   University; National Yang Ming Chiao Tung University; National Health
   Research Institutes - Taiwan; National Cheng Kung University
RP Su, IJ (corresponding author), Natl Hlth Res Inst, 367 Sheng Li Rd, Tainan 704, Taiwan.
RI Su, Ih-Jen/B-2655-2010; Travassos, Leonardo/G-1925-2012; Teng,
   Chiao-Fang/L-6679-2013
OI Teng, Chiao-Fang/0000-0002-5218-0571; SU, HUI-MIN/0000-0002-9970-4459
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NR 36
TC 27
Z9 28
U1 0
U2 10
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0899-1987
EI 1098-2744
J9 MOL CARCINOGEN
JI Mol. Carcinog.
PD JAN
PY 2016
VL 55
IS 1
BP 105
EP 114
DI 10.1002/mc.22266
PG 10
WC Biochemistry & Molecular Biology; Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Oncology
GA DB9BE
UT WOS:000368810100010
PM 25594851
DA 2025-06-11
ER

PT J
AU Woods-Giscombe, CL
   Gaylord, S
   Bradford, A
   Vines, S
   Eason, K
   Smith, R
   Addo-Mensah, D
   Lackey, C
   Dsouza, V
   Sheffield-Abdullah, K
   Day, T
   Green-Scott, K
   Chilcoat, A
   Peace-Coard, A
   Chalmers, L
   Evenson, KR
   Samuel-Hodge, C
   Lewis, TT
   Crandell, J
   Corbie, G
   Faurot, K
AF Woods-Giscombe, Cheryl L.
   Gaylord, Susan
   Bradford, Andrew
   Vines, Sierra
   Eason, Kelly
   Smith, Raven
   Addo-Mensah, Dorothy
   Lackey, Charity
   Dsouza, Vinisha
   Sheffield-Abdullah, Karen
   Day, Tomeka
   Green-Scott, Kerri
   Chilcoat, Aisha
   Peace-Coard, Angela
   Chalmers, LaTonia
   Evenson, Kelly R.
   Samuel-Hodge, Carmen
   Lewis, Tene T.
   Crandell, Jamie
   Corbie, Giselle
   Faurot, Keturah
TI Protocol of the HARMONY study: A culturally relevant,
   randomized-controlled, stress management intervention to reduce
   cardiometabolic risk in African American women
SO CONTEMPORARY CLINICAL TRIALS
LA English
DT Article
DE African American; Women; Cardiometabolic disease; Stress management;
   Superwoman schema
ID WEIGHT-LOSS; PHYSICAL-ACTIVITY; HEALTH BEHAVIORS; MINDFULNESS;
   RECOMMENDATIONS; WHITE; QUESTIONNAIRE; METAANALYSIS; VALIDATION;
   STRENGTH
AB Background: African American Women (AAW) are at high risk for stress-related cardiometabolic (CM) conditions including obesity, heart disease, and diabetes. Prior interventions lack attention to culturally-nuanced stress phenomena (Superwoman Schema [SWS], contextualized stress, and network stress), which are positively and significantly associated with unhealthy eating and sedentary behavior. Purpose: The HARMONY Study is designed to test a culturally tailored mindfulness-based stress management intervention to address SWS, contextualized stress, and network stress as potential barriers to adherence to healthy exercise and eating goals. The study will help AAW build on their strengths to promote cardiometabolic health by enhancing positive reappraisal, self-regulation, and self-efficacy as protective factors against chronic stress-inducing biobehavioral morbidity and mortality risk. Methods: This two-arm, randomized-controlled trial will test the effects of two group-based, online interventions. HARMONY 1 includes culturally-tailored exercise and nutrition education. HARMONY 2 includes mindfulnessbased stress reduction, exercise, and nutrition education. We aim to recruit 200 AAW >= 18 years old with CM risk. Results: Primary outcomes (actigraphy and carotenoid levels) and secondary outcomes (body composition, inflammatory markers, glucose metabolism, and stress) are being collected at baseline and 4-, 8-, and 12-months post-intervention. Intent-to-treat, data analytic approaches will be used to test group differences for the primary outcomes. Discussion: This study is the first to address culturally-nuanced stress phenomena in AAW (SWS, network stress, and contextualized stress) using culturally-tailored stress management, exercise, and nutrition educational approaches to reduce biobehavioral CM risk among AAW. Quantitative and qualitative results will inform the development of scalable and sustainable CM risk-reduction programming for AAW.
C1 [Woods-Giscombe, Cheryl L.; Bradford, Andrew; Vines, Sierra; Smith, Raven; Addo-Mensah, Dorothy; Lackey, Charity; Dsouza, Vinisha; Sheffield-Abdullah, Karen; Day, Tomeka; Green-Scott, Kerri; Peace-Coard, Angela; Chalmers, LaTonia; Crandell, Jamie] Univ N Carolina, Sch Nursing, Chapel Hill, NC 27599 USA.
   [Gaylord, Susan] Univ N Carolina, Sch Med, Program Integrated Med, Chapel Hill, NC USA.
   [Eason, Kelly; Chilcoat, Aisha; Faurot, Keturah] Univ N Carolina, Sch Med, Phys Med Rehab, Chapel Hill, NC USA.
   [Evenson, Kelly R.; Samuel-Hodge, Carmen] Univ N Carolina, Gillings Sch Global Publ Hlth, Chapel Hill, NC USA.
   [Lewis, Tene T.] Emory Univ, Rollins Sch Publ Hlth, Atlanta, GA USA.
   [Corbie, Giselle] Univ N Carolina, Sch Med, Dept Social Med, Chapel Hill, NC USA.
C3 University of North Carolina; University of North Carolina Chapel Hill;
   University of North Carolina School of Medicine; University of North
   Carolina; University of North Carolina Chapel Hill; University of North
   Carolina School of Medicine; University of North Carolina; University of
   North Carolina Chapel Hill; University of North Carolina; University of
   North Carolina Chapel Hill; Emory University; Rollins School Public
   Health; University of North Carolina School of Medicine; University of
   North Carolina; University of North Carolina Chapel Hill
RP Woods-Giscombe, CL (corresponding author), Univ N Carolina, Sch Nursing, Chapel Hill, NC 27599 USA.
EM cheryl.giscombe@unc.edu
RI Evenson, Kelly/ABU-8365-2022; Lewis, Tene/JBS-7332-2023; GISCOMBE,
   CHERYL/AAG-5815-2020; Crandell, Jamie/KCX-8061-2024
OI Addo-Mensah, Dorothy/0000-0002-2867-618X; Wright-Smith,
   Raven/0000-0002-8750-5073; Dsouza, Vinisha Flavia/0000-0002-4046-9802
FU National Institutes of Health (NIH) : National Institute on Minority
   Health and Health Disparities [1R01MDO15388-04]; National Institute of
   Complementary and Integrative Health [2T32AT003378-16]; National Center
   for Advancing Translational Sciences [UM1TR004406]
FX This work was supported by the National Institutes of Health (NIH) :
   National Institute on Minority Health and Health Disparities (Grant #:
   1R01MDO15388-04) , the National Institute of Complementary and
   Integrative Health (Grant #: 2T32AT003378-16) , and the National Center
   for Advancing Translational Sciences (Grant #: UM1TR004406) .
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NR 71
TC 0
Z9 0
U1 3
U2 5
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1551-7144
EI 1559-2030
J9 CONTEMP CLIN TRIALS
JI Contemp. Clin. Trials
PD NOV
PY 2024
VL 146
AR 107604
DI 10.1016/j.cct.2024.107604
EA SEP 2024
PG 8
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA H1I5C
UT WOS:001321046200001
PM 38866096
DA 2025-06-11
ER

PT J
AU Wang, DQ
   Wang, XH
   Han, J
   You, CP
   Liu, ZM
   Wu, ZJ
AF Wang, Danqi
   Wang, Xiaohua
   Han, Jin
   You, Chunping
   Liu, Zhenmin
   Wu, Zhengjun
TI Effect of Lacticaseibacillus casei LC2W Supplementation on
   Glucose Metabolism and Gut Microbiota in Subjects at High Risk of
   Metabolic Syndrome: A Randomized, Double-blinded, Placebo-controlled
   Clinical Trial
SO PROBIOTICS AND ANTIMICROBIAL PROTEINS
LA English
DT Article; Early Access
DE Lacticaseibacillus casei LC2W; Metabolic syndrome; Glucose;
   Inflammation; Gut microbiome
ID MUCOSA; WOMEN; DIET
AB Metabolic syndrome (MetS) is a global epidemic complex and will cause serious metabolic comorbidities without treatment. A prevention strategy for MetS development has been proposed to modulate gut microbiota by probiotic administration to improve intestinal dysbiosis and benefit the host. Lacticaseibacillus casei LC2W has exhibited positive effects in preventing colitis and anti-hypertension in vivo. However, the effect of L. casei LC2W on subjects at high risk of MetS is unknown. Here, a randomized, double-blinded, placebo-controlled study was conducted on 60 subjects with high risk of MetS, and the hypoglycemic and hypolipidemic activity and possible pathways of L. casei LC2W were inferred from the correlation analysis with gut microbiome composition, function, and clinical phenotypic indicators. The results showed that oral administration of L. casei LC2W could exert significant benefits on weight control, glucose and lipid metabolism, inflammatory and oxidative stress parameters, and SCFA production, as well as modulate the composition of gut microbiota. The relative abundance of Lacticaseibacillus, Bifidobacterium, Dorea, and Blautia was enriched, and their interaction with other gut microbes was strengthened by oral administration of L. casei LC2W, which was beneficial in ameliorating gut inflammation, promoting glucose and lipids degradation pathways, thus alleviated MetS. The present study confirmed the prevention effects of L. casei LC2W towards MetS from aspects of clinical outcomes and microflora modulation, providing an alternative strategy for people at high risk of MetS.
C1 [Wang, Danqi; Wang, Xiaohua; Han, Jin; You, Chunping; Liu, Zhenmin; Wu, Zhengjun] Bright Dairy & Food Co Ltd, Shanghai Engn Res Ctr Dairy Biotechnol, Dairy Res Inst, State Key Lab Dairy Biotechnol, Shanghai 200436, Peoples R China.
C3 Bright Dairy & Food Co Ltd
RP Wu, ZJ (corresponding author), Bright Dairy & Food Co Ltd, Shanghai Engn Res Ctr Dairy Biotechnol, Dairy Res Inst, State Key Lab Dairy Biotechnol, Shanghai 200436, Peoples R China.
EM wuzhengjun@brightdairy.com
RI liu, zhenmin/LUY-2605-2024
FU Natural Science Foundation of Shanghai [23ZR1414400]; National Key
   Research and Development Program of China [2022YFD2100704]; Shanghai
   State-owned Assets Supervision and Administration Commission Enterprise
   Innovation Development and Capacity Enhancement Program [2022013]
FX The Natural Science Foundation of Shanghai, 23ZR1414400, 23ZR1414400,
   23ZR1414400, 23ZR1414400, National Key Research and Development Program
   of China, 2022YFD2100704, 2022YFD2100704, The Shanghai State-owned
   Assets Supervision and Administration Commission Enterprise Innovation
   Development and Capacity Enhancement Program, No. 2022013.
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NR 53
TC 0
Z9 0
U1 1
U2 5
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1867-1306
EI 1867-1314
J9 PROBIOTICS ANTIMICRO
JI Probiotics Antimicrob. Proteins
PD 2024 JUL 2
PY 2024
DI 10.1007/s12602-024-10312-5
EA JUL 2024
PG 15
WC Biotechnology & Applied Microbiology; Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Microbiology
GA XJ0I7
UT WOS:001261195400001
PM 38954305
OA hybrid
DA 2025-06-11
ER

PT J
AU D'Amico, R
   Siracusa, R
   Cordaro, M
   Fusco, R
   Arangia, A
   Interdonato, L
   Marino, Y
   Franco, GA
   Cuzzocrea, S
   Di Paola, R
   Impellizzeri, D
AF D'Amico, Ramona
   Siracusa, Rosalba
   Cordaro, Marika
   Fusco, Roberta
   Arangia, Alessia
   Interdonato, Livia
   Marino, Ylenia
   Franco, Gianluca Antonio
   Cuzzocrea, Salvatore
   Di Paola, Rosanna
   Impellizzeri, Daniela
TI Osteopontin as a Biomarker for Early Diagnosis of Renal Damage during
   Experimental Metabolic Syndrome
SO JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
LA English
DT Article
DE metabolic syndrome; fructose; osteopontin; kidney injury; biomarker
ID TUBULOINTERSTITIAL INJURY; INTERSTITIAL FIBROSIS; DIETARY FRUCTOSE;
   OXIDATIVE STRESS; KIDNEY ISCHEMIA; DISEASE; PALMITOYLETHANOLAMIDE;
   INFLAMMATION; NEUROINFLAMMATION; STRATIFICATION
AB Background: Excess consumption of fructose is a significant factor in the development of metabolic syndrome (MetS). It may also play a role in the progress of chronic kidney disease (CKD). Osteopontin (OPN) is a pleiotropic, multi-phosphorylated glycoprotein which plays important roles in diseases as well as in a wide range of biological activities. Based on these findings, the aim of this study was to evaluate OPN as a biomarker for the early detection of renal injury during an experimental model of fructose associated MetS in mice.Methods: Male CD1 mice aged 8-10 weeks were used. Fructose mice were given 30% fructose solution in drinking water, while control mice were given normal drinking water for 56 days. At sacrifice, kidneys, blood and urine of mice were collected. Bio-chemical, histological (hematoxylin and eosin and Masson's trichrome), immunohistochemical and molecular analyses (western blot, real-time quantitative polymerase chain reaction (RT-qPCR)) were performed.Results: Compared to controls, Fructose mice showed increased levels of glucose, total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL), alanine aminotransferase (ALT), and aspartate aminotransferase (AST), as well as creatinine and blood urea nitrogen (BUN). In addition, significant histological kidney injury and fibrosis were observed in Fructose mice. These alterations were associated with increased levels of plasma and renal tissue OPN. Conclusions: Thus, new biomarkers such as OPN can be clinically useful to help predict kidney damage in MetS.
C1 [D'Amico, Ramona; Siracusa, Rosalba; Fusco, Roberta; Arangia, Alessia; Interdonato, Livia; Marino, Ylenia; Cuzzocrea, Salvatore; Impellizzeri, Daniela] Univ Messina, Dept ChemBiol Pharmaceut & Environm Sci, I-98166 Messina, Italy.
   [Cordaro, Marika] Univ Messina, Dept Biomed Dent & Morphol & Funct Imaging, I-98125 Messina, Italy.
   [Franco, Gianluca Antonio; Di Paola, Rosanna] Univ Messina, Dept Vet Sci, I-98168 Messina, Italy.
C3 University of Messina; University of Messina; University of Messina
RP Di Paola, R (corresponding author), Univ Messina, Dept Vet Sci, I-98168 Messina, Italy.
EM dipaolar@unime.it
RI FUSCO, Roberta/AAC-1745-2019; Impellizzeri, Daniela/K-6087-2016;
   Cuzzocrea, Salvatore/K-4734-2016; Siracusa, Rosalba/AAC-3110-2022;
   Cordaro, Marika/K-7329-2016; D'Amico, Ramona/AAC-9061-2019
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NR 54
TC 1
Z9 1
U1 1
U2 4
PU BIOLIFE SAS
PI SILVA MARINA (TE)
PA VIA S STEFANO 39 BIS, 64029 SILVA MARINA (TE), ITALY
SN 0393-974X
EI 1724-6083
J9 J BIOL REG HOMEOS AG
JI J. Biol. Regul. Homeost. Agents
PD DEC
PY 2023
VL 37
IS 12
BP 6501
EP 6510
DI 10.23812/j.biol.regul.homeost.agents.20233712.615
PG 10
WC Endocrinology & Metabolism; Immunology; Medicine, Research &
   Experimental; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Immunology; Research & Experimental
   Medicine; Physiology
GA DX1X3
UT WOS:001135300400001
DA 2025-06-11
ER

PT J
AU Kountouras, J
   Kazakos, E
   Kyrailidi, F
   Polyzos, SA
   Zavos, C
   Arapoglou, S
   Boziki, M
   Mouratidou, MC
   Tzitiridou-Chatzopoulou, M
   Chatzopoulos, D
   Doulberis, M
   Papaefthymiou, A
   Vardaka, E
AF Kountouras, Jannis
   Kazakos, Evangelos
   Kyrailidi, Foteini
   Polyzos, Stergios A.
   Zavos, Christos
   Arapoglou, Stergios
   Boziki, Marina
   Mouratidou, Maria C.
   Tzitiridou-Chatzopoulou, Maria
   Chatzopoulos, Dimitrios
   Doulberis, Michael
   Papaefthymiou, Apostolis
   Vardaka, Elisabeth
TI Innate immunity and nonalcoholic fatty liver disease
SO ANNALS OF GASTROENTEROLOGY
LA English
DT Review
DE Innate immune response; nonalcoholic fatty liver disease;
   metabolic-associated fatty liver disease; liver fibrosis; metabolic
   syndrome
ID NATURAL-KILLER-CELLS; INTESTINAL MICROBIOTA; COMPLEMENT-SYSTEM; HEPATIC
   STEATOSIS; T-CELLS; STEATOHEPATITIS; ACTIVATION; FIBROSIS; INFLAMMATION;
   PROGRESSION
AB Nonalcoholic fatty liver disease (NAFLD), recently renamed as metabolic (dysfunction)-associated fatty liver disease (MAFLD), is a complex, multifactorial disease that progresses via nonalcoholic steatohepatitis (NASH) towards severe liver complications. MAFLD/NAFLD affects up to a third of the global population. It is connected with metabolic syndrome parameters and has been increasing in parallel with the rates of metabolic syndrome parameters worldwide. This disease entity exhibits a strong immune-inflammatory dimension. In MAFLD/NAFLD/NASH, a vast network of innate immune cells is mobilized that can provoke liver damage, leading to advanced fibrosis, cirrhosis and its complications, including hepatocellular carcinoma. However, our understanding of the inflammatory signals that drive the onset and progression of MAFLD/NAFLD/NASH is fragmented. Thus, further investigation is required to better understand the role of specific innate immune cell subsets in the disease, and to aid the design of innovative therapeutic agents to target MAFLD/NAFLD/NASH. In this review, we discuss current concepts regarding the role of innate immune system involvement in MAFLD/NAFLD/NASH onset and progression, along with presenting potential stress signals affecting immune tolerance that may trigger aberrant immune responses. A comprehensive understanding of the innate immune mechanisms involved in MAFLD/NAFLD/NASH pathophysiology will help the discovery of early interventions to prevent the disease, and lead to potential innovative therapeutic strategies that may limit its worldwide burden.
C1 [Kountouras, Jannis; Kazakos, Evangelos; Kyrailidi, Foteini; Zavos, Christos; Arapoglou, Stergios; Mouratidou, Maria C.; Chatzopoulos, Dimitrios; Doulberis, Michael; Papaefthymiou, Apostolis; Vardaka, Elisabeth] Aristotle Univ Thessaloniki, Sch Med, Ippokrat Hosp, Med Clin 2, Macedonia, Greece.
   [Kazakos, Evangelos] Univ West Macedonia, Midwifery Dept, Sch Healthcare Sci, Kozani, Macedonia, Greece.
   [Polyzos, Stergios A.; Doulberis, Michael; Papaefthymiou, Apostolis] Aristotle Univ Thessaloniki, Sch Med, Lab Pharmacol 1, Thessaloniki, Macedonia, Greece.
   [Arapoglou, Stergios] Aristotle Univ Thessaloniki, Med Sch, Ippokrat Hosp, Surg Dept 5, Thessaloniki, Macedonia, Greece.
   [Boziki, Marina] Aristotle Univ Thessaloniki, Sch Med, AHEPA Hosp, Neurol Dept 2,Fac Hlth Sci, Thessaloniki, Macedonia, Greece.
   [Tzitiridou-Chatzopoulou, Maria] Univ West Macedonia, Midwifery Dept, Sch Healthcare Sci, Kozani, Macedonia, Greece.
   [Doulberis, Michael] Univ Zurich, Dept Gastroenterol & Hepatol, Zurich, Switzerland.
   [Papaefthymiou, Apostolis] Univ Coll London Hosp UCLH, Pancreaticobiliary Med Unit, London, England.
   [Vardaka, Elisabeth] Int Hellen Univ, Sch Hlth Sci, Dept Nutr Sci & Dietet, Alexander Campus, Thessaloniki, Macedonia, Greece.
C3 Aristotle University of Thessaloniki; Aristotle University of
   Thessaloniki; Aristotle University of Thessaloniki; Aristotle University
   of Thessaloniki; Ahepa University Hospital; University of Zurich;
   University College London Hospitals NHS Foundation Trust; International
   Hellenic University
RP Kountouras, J (corresponding author), Med, 8 Fanariou St,Byzantio, Thessaloniki 55133, Macedonia, Greece.
EM jannis@auth.gr
RI Boziki, Marina/ACF-8768-2022; VARDAKA, Elisabeth/ABD-1341-2020; Polyzos,
   Stergios/H-2844-2019; Doulberis, Michael/Y-5118-2018; Tzitiridou, Dr.
   Maria/KHW-8314-2024; Papaefthymiou, Apostolis/HPH-4021-2023; Zavos,
   Christos/N-8618-2015
OI Doulberis, Michael/0000-0002-0396-5081; Tzitiridou, Dr.
   Maria/0000-0001-6051-0860; Papaefthymiou, Apostolis/0000-0002-3563-4973;
   Kazakos, Evangelos/0000-0002-3045-720X; Zavos,
   Christos/0000-0002-3443-7791
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NR 100
TC 14
Z9 14
U1 4
U2 12
PU HELLENIC SOC GASTROENTEROLOGY
PI ATHENS
PA DEMOKRATIAS AVE 67, ATHENS, 15451, GREECE
SN 1108-7471
EI 1792-7463
J9 ANN GASTROENTEROL
JI Ann. Gastroenterol.
PY 2023
VL 36
IS 3
BP 244
EP 256
DI 10.20524/aog.2023.0793
PG 13
WC Gastroenterology & Hepatology
WE Emerging Sources Citation Index (ESCI)
SC Gastroenterology & Hepatology
GA H4QX2
UT WOS:000995836800002
PM 37144011
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Sao, R
   Aronow, WS
AF Sao, Rahul
   Aronow, Wilbert S.
TI Association of non-alcoholic fatty liver disease with cardiovascular
   disease and subclinical atherosclerosis
SO ARCHIVES OF MEDICAL SCIENCE
LA English
DT Article
DE non-alcoholic fatty liver disease; coronary artery disease;
   atherosclerotic cardiovascular disease
ID CORONARY-ARTERY-DISEASE; ANKLE VASCULAR INDEX; INTIMA-MEDIA THICKNESS;
   HEPATIC INSULIN-RESISTANCE; TYPE-2 DIABETES-MELLITUS; METABOLIC
   SYNDROME; BARIATRIC SURGERY; CAROTID ATHEROSCLEROSIS; COLLATERAL
   CIRCULATION; SYSTEMIC INFLAMMATION
AB Non-alcoholic fatty liver disease (NAFLD) refers to fatty infiltration of liver in the absence of significant alcohol intake, use of steatogenic medication, or hereditary disorders. It is a common cause of chronic liver disease with a worldwide estimated prevalence ranging from 6.3% to 33%. The NAFLD is considered a hepatic manifestation of the metabolic syndrome. Insulin resistance and increased oxidative stress are central to pathogenesis of NAFLD, and risk factors include metabolic syndrome, diabetes mellitus, obesity, lack of physical activity, smoking, and high fat diet. NAFLD is associated with higher mortality as compared to the general population with cardiovascular disease being the most common cause of death. The NAFLD is associated with a higher prevalence of subclinical atherosclerosis as evidenced by odds of higher coronary artery calcification, higher average and maximum carotid intima-media thickness. It is also associated with stiff arteries as evidenced by higher cardio-ankle vascular index and higher brachial-ankle pulse wave velocity. Increasing evidence has linked NAFLD with atherosclerotic cardiovascular diseases. The NAFLD is associated with a higher prevalence of coronary artery disease (CAD), more severe CAD, poor coronary collateral development, and higher incidence of coronary events. The NAFLD is also associated with ischemic stroke. Studies have shown that the association between NAFLD and atherosclerotic cardiovascular diseases is independent of shared risk factors.
C1 [Sao, Rahul; Aronow, Wilbert S.] New York Med Coll, Westchester Med Ctr, Dept Med, Cardiol Div, Valhalla, NY 10595 USA.
C3 Westchester Medical Center; New York Medical College
RP Aronow, WS (corresponding author), New York Med Coll, Cardiol Div, Macy Pavil,Room 141, Valhalla, NY 10595 USA.
EM wsaronow@aol.com
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NR 113
TC 38
Z9 43
U1 0
U2 7
PU TERMEDIA PUBLISHING HOUSE LTD
PI POZNAN
PA KLEEBERGA ST 2, POZNAN, 61-615, POLAND
SN 1734-1922
EI 1896-9151
J9 ARCH MED SCI
JI Arch. Med. Sci.
PD OCT
PY 2018
VL 14
IS 6
BP 1233
EP 1244
DI 10.5114/aoms.2017.68821
PG 12
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA GX8NY
UT WOS:000448045000004
PM 30393477
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Ferramosca, A
   Conte, A
   Moscatelli, N
   Zara, V
AF Ferramosca, A.
   Conte, A.
   Moscatelli, N.
   Zara, V.
TI A high-fat diet negatively affects rat sperm mitochondrial respiration
SO ANDROLOGY
LA English
DT Article
DE High-fat diet; male infertility; metabolic syndrome; sperm mitochondria
ID METABOLIC SYNDROME; OXIDATIVE STRESS; GLYCOLYSIS PLAYS; HORMONE-LEVELS;
   SEMEN QUALITY; INFERTILITY; DEHYDROGENASES; SPERMATOZOA; FERTILITY;
   FLAGELLUM
AB Recent evidences have linked abdominal obesity, insulin resistance, and dyslipidemia to male infertility. Since a defective energy metabolism may play an important role in the impairment of sperm quality, the aim of this study is to investigate the sperm energetic metabolism in rats fed with a high-fat diet, an animal model associated with metabolic syndrome development. Sexually mature male Sprague-Dawley rats were divided into two groups and fed for 4weeks a standard diet (control group) or a diet enriched in 35% of fat (high fat group). Liver and adipose tissue weight, plasma glucose, insulin, and lipid concentrations were determined. Activities of enzymes involved in sperm energetic metabolism were evaluated by spectrophotometric assays. Sperm mitochondrial respiratory activity was evaluated with a polarographic assay of oxygen consumption. The administration of a high-fat diet caused a significant increase in body weight of rats and provoked hyperglycemia, hyperinsulinemia, and dyslipidemia. In these animals, we also observed a reduction in sperm concentration and motility. The investigation of sperm energetic metabolism in animals fed a high-fat diet revealed an impairment in the activity of pyruvate and lactate dehydrogenase, citrate synthase, and respiratory chain complexes. A parallel reduction in the cellular levels of adenosine triphosphate (ATP) and an increase in oxidative damage were also observed. A defective energy metabolism may play an important role in the impairment of sperm quality in the high-fat diet fed rats.
C1 [Ferramosca, A.; Conte, A.; Moscatelli, N.; Zara, V.] Univ Salento, Dipartimento Sci & Tecnol Biol Ambientali, Via Prov Lecce Monteroni, I-73100 Lecce, Italy.
C3 University of Salento
RP Ferramosca, A (corresponding author), Univ Salento, Dipartimento Sci & Tecnol Biol Ambientali, Via Prov Lecce Monteroni, I-73100 Lecce, Italy.
EM alessandra.ferramosca@unisalento.it
RI Zara, Vincenzo/AAC-2900-2019; Ferramosca, Alessandra/B-8801-2015
OI MOSCATELLI, NATALINA/0000-0002-9291-9588; Zara,
   Vincenzo/0000-0001-6592-4501; Ferramosca, Alessandra/0000-0002-8251-9652
FU Fondazione Cassa di Risparmio di Puglia
FX This research was financially supported by Fondazione Cassa di Risparmio
   di Puglia, regarding the project 'Obesita e infertilita maschile: ruolo
   degli acidi grassi nella modulazione del metabolismo energetico degli
   spermatozoi'.
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NR 37
TC 49
Z9 52
U1 0
U2 29
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2047-2919
EI 2047-2927
J9 ANDROLOGY-US
JI Andrology
PD MAY
PY 2016
VL 4
IS 3
BP 520
EP 525
DI 10.1111/andr.12182
PG 6
WC Andrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA DL8HG
UT WOS:000375881200021
PM 27062222
OA Bronze
DA 2025-06-11
ER

PT J
AU Berkovic, MC
   Virovic-Jukic, L
   Bilic-Curcic, I
   Mrzljak, A
AF Cigrovski Berkovic, Maja
   Virovic-Jukic, Lucija
   Bilic-Curcic, Ines
   Mrzljak, Anna
TI Post-transplant diabetes mellitus and preexisting liver disease-a
   bidirectional relationship affecting treatment and management
SO WORLD JOURNAL OF GASTROENTEROLOGY
LA English
DT Review
DE Diabetes mellitus; Liver transplantation; Non-alcoholic fatty liver
   disease; Metabolic syndrome; Insulin-resistance; Glucagon-like peptide-1
   receptor agonists; Sodium-glucose cotransporter 2 inhibitors
ID HEPATITIS-C VIRUS; SERUM URIC-ACID; LAPAROSCOPIC SLEEVE GASTRECTOMY;
   RENAL-TRANSPLANT RECIPIENTS; PEPTIDE-1 RECEPTOR AGONISTS; CHRONIC
   KIDNEY-DISEASE; INSULIN-RESISTANCE; NONALCOHOLIC STEATOHEPATITIS;
   CARDIOVASCULAR-DISEASE; RISK-FACTORS
AB Liver cirrhosis and diabetes mellitus (DM) are both common conditions with significant socioeconomic burden and impact on morbidity and mortality. A bidirectional relationship exists between DM and liver cirrhosis regarding both etiology and disease-related complications. Type 2 DM (T2DM) is a well-recognized risk factor for chronic liver disease and vice-versa, DM may develop as a complication of cirrhosis, irrespective of its etiology. Liver transplantation (LT) represents an important treatment option for patients with end-stage liver disease due to non-alcoholic fatty liver disease (NAFLD), which represents a hepatic manifestation of metabolic syndrome and a common complication of T2DM. The metabolic risk factors including immunosuppressive drugs, can contribute to persistent orde novodevelopment of DM and NAFLD after LT. T2DM, obesity, cardiovascular morbidities and renal impairment, frequently associated with metabolic syndrome and NAFLD, may have negative impact on short and long-term outcomes following LT. The treatment of DM in the context of chronic liver disease and post-transplant is challenging, but new emerging therapies such as glucagon-like peptide-1 receptor agonists (GLP-1RAs) and sodium-glucose cotransporter 2 inhibitors (SGLT2i) targeting multiple mechanisms in the shared pathophysiology of disorders such as oxidative stress and chronic inflammation are a promising tool in future patient management.
C1 [Cigrovski Berkovic, Maja] Univ Zagreb, Fac Kinesiol, Dept Kinesiol Anthropol & Methodol, Zagreb 10000, Croatia.
   [Cigrovski Berkovic, Maja] Clin Hosp Dubrava, Zagreb 10000, Croatia.
   [Cigrovski Berkovic, Maja; Bilic-Curcic, Ines] Univ JJ Strossmayer Osijek, Fac Med, Dept Pharmacol, Osijek 31000, Croatia.
   [Virovic-Jukic, Lucija; Bilic-Curcic, Ines; Mrzljak, Anna] Univ Zagreb, Sch Med, Salata 3b, Zagreb 10000, Croatia.
   [Virovic-Jukic, Lucija] Sisters Char Univ Hosp, Dept Med, Div Gastroenterol & Hepatol, Zagreb 10000, Croatia.
   [Bilic-Curcic, Ines] Clin Hosp Ctr Osijek, Osijek 31000, Croatia.
   [Mrzljak, Anna] Merkur Univ Hosp, Dept Med, Zagreb 10000, Croatia.
C3 University of Zagreb; University of Zagreb, Faculty of Kinesiology;
   University of Zagreb; University of JJ Strossmayer Osijek; University of
   Zagreb
RP Mrzljak, A (corresponding author), Univ Zagreb, Sch Med, Salata 3b, Zagreb 10000, Croatia.
EM anna.mrzljak@mef.hr
RI Cigrovski Berkovic, Maja/AAB-7735-2019; Mrzljak, Anna/J-7465-2017;
   Curcic, Ines/R-6013-2018
OI Cigrovski Berkovic, Maja/0000-0003-0750-9785
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NR 164
TC 11
Z9 11
U1 0
U2 3
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 7041 Koll Center Parkway, Suite 160, PLEASANTON, CA, UNITED STATES
SN 1007-9327
EI 2219-2840
J9 WORLD J GASTROENTERO
JI World J. Gastroenterol.
PD JUN 7
PY 2020
VL 26
IS 21
BP 2740
EP 2757
DI 10.3748/wjg.v26.i21.2740
PG 18
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA LZ3WB
UT WOS:000541157700006
PM 32550751
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Moreira, ALG
   Silva, PHF
   Salvador, SL
   Ishikawa, KH
   Ferreira, GC
   Tanus-Santos, JE
   Mayer, MPA
   de Souza, SLS
   Furlaneto, FAC
   Messora, MR
AF Moreira, Andre L. G.
   Silva, Pedro H. F.
   Salvador, Sergio L.
   Ishikawa, Karin H.
   Ferreira, Graziele C.
   Tanus-Santos, Jose E.
   Mayer, Marcia P. A.
   de Souza, Sergio L. S.
   Furlaneto, Flavia A. C.
   Messora, Michel R.
TI Effects of probiotics in rats with experimental metabolic syndrome and
   periodontitis: An investigation of the intestine-adipose tissue axis
SO JOURNAL OF PERIODONTOLOGY
LA English
DT Article
DE metabolic syndrome; periodontitis; probiotics
ID FATTY LIVER-DISEASE; OXIDATIVE STRESS; ASSOCIATION; LACTIS;
   INFLAMMATION; EXPRESSION; THERAPY; LIPIDS; MODEL
AB BackgroundThis study evaluated the systemic (intestine and adipose tissue) and local (periodontal tissues) impact of probiotic therapy in rats with metabolic syndrome (MS) associated or not with periodontitis (PE). MethodsForty-eight rats received a high-fat diet for induction of MS for 16 weeks. They were subdivided into groups with (+) and without (-) PE, receiving (*) or not (**) receiving probiotics (PROB): MS (-**), MSP (-*), MSPE (+**), and MSPEP (+*). PROB administration (Bifidobacterium animalis subsp. lactis HN019) started on the 8th week of the study and PE was induced on the 14th week by placing ligature on the animals' lower first molars. Euthanasia occurred in the 16th week. Biomolecular, immunoenzymatic assays, and histomorphometric analyses were performed. The data obtained were statistically analyzed (ANOVA, Tukey, p < 0.05). ResultsThe MSPEP group exhibited reduced alveolar bone loss when compared with the MSPE group, as well as lower levels of hepatic steatosis and proteinuria (p < 0.05). In the intestinal environment, the MSPE group exhibited significantly lower villus height and crypt depth, as well as a greater increase in Bacillota when compared with the MSPEP group (p < 0.05). The MSPEP group showed lower adipokine gene expression (LEPR, NAMPT, and FABP4) in adipose tissue than the MSPE group (p < 0.05). ConclusionThe probiotic B. lactis HN019 reduced the severity of experimental periodontitis and modulated the expression of lipogenic genes and intestinal morphological and microbiological parameters in rats with MS.
C1 [Moreira, Andre L. G.; Silva, Pedro H. F.; de Souza, Sergio L. S.; Furlaneto, Flavia A. C.; Messora, Michel R.] Univ Sao Paulo, Sch Dent Ribeirao Preto, Dept Oral & Maxillofacial Surg & Periodontol, Ribeirao Preto, SP, Brazil.
   [Salvador, Sergio L.] Univ Sao Paulo, Sch Pharmaceut Sci Ribeirao Preto, Dept Clin Anal, Ribeirao Preto, SP, Brazil.
   [Ishikawa, Karin H.; Mayer, Marcia P. A.] Univ Sao Paulo, Inst Biomed Sci, Dept Microbiol, Sao Paulo, Brazil.
   [Ferreira, Graziele C.; Tanus-Santos, Jose E.] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Pharmacol, Ribeirao Preto, SP, Brazil.
   [Furlaneto, Flavia A. C.] Univ Sao Paulo, Sch Dent Ribeirao Preto, Dept Oral & Maxillofacial Surg & Periodontol, Ave Cafe s-n Ribeirao Preto-SP14020 150, Ribeirao Preto, SP, Brazil.
C3 Universidade de Sao Paulo; Universidade de Sao Paulo; Universidade de
   Sao Paulo; Institute Biomed Science, University Sao Paulo; Universidade
   de Sao Paulo; Universidade de Sao Paulo
RP Furlaneto, FAC (corresponding author), Univ Sao Paulo, Sch Dent Ribeirao Preto, Dept Oral & Maxillofacial Surg & Periodontol, Ave Cafe s-n Ribeirao Preto-SP14020 150, Ribeirao Preto, SP, Brazil.
EM flafurlaneto@usp.br
RI Ferreira, Graziele/D-9011-2018; Furlaneto, Flavia/C-4171-2013; Salvador,
   Sergio/G-1015-2019; de Souza, Sergio/F-8803-2014; Messora,
   Michel/F-3480-2012; Felix Silva, Pedro Henrique/S-2286-2019; Mayer,
   Marcia/D-4645-2012
OI Salvador, Sergio Luiz/0000-0002-4867-7294; ISHIKAWA,
   KARIN/0000-0003-3926-3572; Felix Silva, Pedro
   Henrique/0000-0002-7583-7046; Mayer, Marcia/0000-0002-5910-8433
FU Sao Paulo Research Foundation [2017/26257-9, 2018/16009-0]
FX Sao Paulo Research Foundation,Grant/Award Numbers: FAPESP -Funding
   2017/26257-9, 2018/16009-0
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NR 68
TC 1
Z9 1
U1 2
U2 12
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-3492
EI 1943-3670
J9 J PERIODONTOL
JI J. Periodont.
PD NOV
PY 2023
VL 94
IS 11
BP 1363
EP 1375
DI 10.1002/JPER.22-0721
EA MAY 2023
PG 13
WC Dentistry, Oral Surgery & Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dentistry, Oral Surgery & Medicine
GA Y2SH2
UT WOS:000991868700001
PM 37057371
DA 2025-06-11
ER

PT J
AU McPherson, KC
   Shields, CA
   Poudel, B
   Fizer, B
   Pennington, A
   Szabo-Johnson, A
   Thompson, WL
   Cornelius, DC
   Williams, JM
AF McPherson, Kasi C.
   Shields, Corbin A.
   Poudel, Bibek
   Fizer, Brianca
   Pennington, Alyssa
   Szabo-Johnson, Ashley
   Thompson, Willie L.
   Cornelius, Denise C.
   Williams, Jan M.
TI Impact of obesity as an independent risk factor for the development of
   renal injury: implications from rat models of obesity
SO AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
LA English
DT Review
DE high-fat diet; leptin; metabolic syndrome; obesity; renal disease
ID DIET-INDUCED OBESITY; CHRONIC KIDNEY-DISEASE; SPONTANEOUSLY
   HYPERTENSIVE-RATS; INITIATED METABOLIC SYNDROME; SYMPATHETIC-NERVE
   ACTIVITY; SALT-SENSITIVE RATS; BODY-MASS INDEX; HIGH-FAT; OXIDATIVE
   STRESS; BLOOD-PRESSURE
AB Diabetes and hypertension are the major causes of chronic kidney disease (CKD). Epidemiological studies within the last few decades have revealed that obesity-associated renal disease is an emerging epidemic and that the increasing prevalence of obesity parallels the increased rate of CKD. This has led to the inclusion of obesity as an independent risk factor for CKD. A major complication when studying the relationship between obesity and renal injury is that cardiovascular and metabolic disorders that may result from obesity including hyperglycemia, hypertension, and dyslipidemia, or the cluster of these disorders [defined as the metabolic syndrome, (MetS)] also contribute to the development and progression of renal disease. The associations between hyperglycemia and hypertension with renal disease have been reported extensively in patients suffering from obesity. Currently, there are several obese rodent models (high-fat diet-induced obesity and leptin signaling dysfunction) that exhibit characteristics of MetS. However, the available obese rodent models currently have not been used to investigate the impact of obesity alone on the development of renal injury before hypertension and/ or hyperglycemia. Therefore, the aim of this review is to describe the incidence and severity of renal disease in these rodent models of obesity and determine which models are suitable to study the independent effects obesity on the development and progression of renal disease.
C1 [McPherson, Kasi C.; Shields, Corbin A.; Poudel, Bibek; Fizer, Brianca; Pennington, Alyssa; Szabo-Johnson, Ashley; Thompson, Willie L.; Cornelius, Denise C.; Williams, Jan M.] Univ Mississippi, Med Ctr, Dept Pharmacol & Toxicol, 2500 North State St, Jackson, MS 39219 USA.
   [Cornelius, Denise C.] Univ Mississippi, Med Ctr, Dept Emergency Med, Jackson, MS 39216 USA.
C3 University of Mississippi Medical Center; University of Mississippi;
   University of Mississippi Medical Center; University of Mississippi
RP Williams, JM (corresponding author), Univ Mississippi, Med Ctr, Dept Pharmacol & Toxicol, 2500 North State St, Jackson, MS 39219 USA.
EM jmwilliams5@umc.edu
OI Cornelius, Denise/0000-0002-6730-6499; Poudel, Dr.
   Bibek/0000-0003-1353-7002
FU National Institute of Diabetes and Digestive and Kidney Diseases
   [1F31-DK-109571, DK-109133]; National Heart, Lung, and Blood Institute
   [HL-130456]; National Institute of General Medical Sciences (Obesity,
   Cardiorenal and Metabolic Diseases-COBRE) [P20-GM-104357, GM-115428]
FX This work was financially supported by the National Institute of
   Diabetes and Digestive and Kidney Diseases Grants 1F31-DK-109571 (to K.
   C. McPherson) and DK-109133 (to J. M. Williams) and National Heart,
   Lung, and Blood Institute Grant HL-130456 and National Institute of
   General Medical Sciences (Obesity, Cardiorenal and Metabolic
   Diseases-COBRE) Grants P20-GM-104357 (to D. C. Cornelius) and GM-115428
   supported summer undergraduate students (to A. Pennington and B. Fizer)
   and P20-GM-104357 (to J. M. Williams).
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NR 154
TC 26
Z9 31
U1 0
U2 5
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 1931-857X
EI 1522-1466
J9 AM J PHYSIOL-RENAL
JI Am. J. Physiol.-Renal Physiol.
PD FEB
PY 2019
VL 316
IS 2
BP F316
EP F327
DI 10.1152/ajprenal.00162.2018
PG 12
WC Physiology; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology; Urology & Nephrology
GA HL3PE
UT WOS:000458627200011
PM 30539649
OA Green Published
DA 2025-06-11
ER

PT J
AU Pham, TAV
AF Pham, T. A. V.
TI The association between periodontal disease severity and metabolic
   syndrome in Vietnamese patients
SO INTERNATIONAL JOURNAL OF DENTAL HYGIENE
LA English
DT Article
DE metabolic syndrome; periodontal disease; Vietnamese
ID OXIDATIVE STRESS; ENDOTHELIAL DYSFUNCTION; DIABETES-MELLITUS; US
   POPULATION; RISK-FACTORS; INFECTION; JAPANESE; MARKERS; HEALTH;
   INFLAMMATION
AB Objective: To investigate the association between periodontal disease severity and metabolic syndrome (MetS) in a group of Vietnamese patients.
   Methods: A total of 412 participants (114 males, 298 females, average age 57.8 +/- 5.7years) including 206 patients with MetS and 206 participants without MetS were selected for this study. Information on sociodemographic characteristics, dental behaviours and smoking status was collected from a self-administrated questionnaire. Periodontal status including plaque index (PI), gingival index (GI) pocket depth (PD) and clinical attachment level (CAL) was recorded. Logistic regression analyses were used to evaluate the association between severity of periodontal disease and MetS with adjustments for related confounders.
   Results: The prevalence of moderate and severe periodontitis assessed by GI, PD and CAL was all significantly higher in the MetS group than in the control group and was significantly increased by a number of MetS components. Logistic regression, adjusted for confounders, showed that people with mean PI >= 2.51 or GI >= 1.01 or number of teeth with bleeding on probing of 20 teeth or PD 3.66 or CAL 3.66 showed a significant association with greater OR for MetS compared to counterparts (P < .05). The OR for MetS was 4.06 (95% CI 2.11-7.84) in severe periodontitis patients compared to non-periodontitis participants (P < .001).
   Conclusion: Much severe and extensive periodontal disease was found in MetS participants and increased with number of MetS components. Participants with higher periodontal parameters had a higher risk of MetS.
C1 [Pham, T. A. V.] Univ Med & Pharm, Fac Odontostomatol, Dept Periodontol, Ho Chi Minh City, Vietnam.
C3 Hochiminh City University of Medicine & Pharmacy
RP Pham, TAV (corresponding author), Univ Med & Pharm, Fac Odontostomatol, Dept Periodontol, Ho Chi Minh City, Vietnam.
EM pavthuy@ump.edu.vn
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NR 41
TC 19
Z9 21
U1 1
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1601-5029
EI 1601-5037
J9 INT J DENT HYG
JI Int. J. Dent. Hyg.
PD NOV
PY 2018
VL 16
IS 4
BP 484
EP 491
DI 10.1111/idh.12350
PG 8
WC Dentistry, Oral Surgery & Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dentistry, Oral Surgery & Medicine
GA GW9GP
UT WOS:000447291600008
PM 29900658
DA 2025-06-11
ER

PT J
AU Aksu, AEK
   Saraçoglu, ZN
   Metintas, S
   Sabuncu, I
   Çetin, Y
AF Aksu, Ayse Esra Koku
   Saracoglu, Zeynep Nurhan
   Metintas, Selma
   Sabuncu, Ilham
   Cetin, Yildiz
TI Age and gender differences in Framingham risk score and metabolic
   syndrome in psoriasis patients: A cross-sectional study in the Turkish
   population
SO ANATOLIAN JOURNAL OF CARDIOLOGY
LA English
DT Article
DE Framingham risk score; metabolic syndrome; psoriasis
ID CORONARY-HEART-DISEASE; OBESE-PATIENTS; PREVALENCE; DIAGNOSIS; MODERATE;
   THERAPY; ASSOCIATION; PREDICTION; STRESS
AB Objective: Psoriasis is associated with an increased frequency of cardiovascular risk factors. Metabolic syndrome ( MS) and the Framingham risk score (FRS) are two different algorithms for evaluating cardiovascular risk. They include different features: waist circumference measurement is included in the MS criteria, whereas smoking, age, and gender are questioned in FRS. This study aimed to evaluate the frequency of MS and FRS in psoriasis patients compared with a control group and investigate the differences between MS and FRS.
   Methods: This was a cross-sectional study involving 300 psoriasis patients and 177 controls. MS, FRS, and disease severity were evaluated.
   Results: The frequency of MS was higher in females with psoriasis than in those in the control group (p=0.019). Females in the psoriasis group were more obese than those in the control group (p=0.036). FRS significantly differed between the patients and controls of age >60 years (p=0.006). The risk of hypertension in current and past smokers was higher in the psoriasis patients (OR=2.07 and 2.32-2.48, respectively) than in the control group. There was no statistically significant relationship among MS, FRS, and psoriasis severity (p>0.05).
   Conclusion: The results of this study support the evaluation of cardiovascular risk assessment in female psoriasis patients with MS and in male and elderly psoriasis patients with FRS.
C1 [Aksu, Ayse Esra Koku; Saracoglu, Zeynep Nurhan; Sabuncu, Ilham] Eskisehir Osmangazi Univ, Dept Dermatol, Eskisehir, Turkey.
   [Metintas, Selma] Eskisehir Osmangazi Univ, Dept Publ Hlth, Eskisehir, Turkey.
   [Cetin, Yildiz] Kent Hosp, Dept Dermatol, Kutahya, Turkey.
C3 Eskisehir Osmangazi University; Eskisehir Osmangazi University; Kent
   Hospital
RP Aksu, AEK (corresponding author), Istanbul Egitim & Arastirma Hastanesi, Cildiye Bolumu, Kasap Ilyas Mah,Org Abdurrahman Nafiz Gurman Cd, TR-34098 Istanbul, Turkey.
EM esraaksu@gmail.com
RI Koku Aksu, Ayse/ADK-4325-2022
OI Metintas, Selma/0000-0002-5002-5041; Koku Aksu, Ayse
   Esra/0000-0002-3457-1958
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NR 45
TC 11
Z9 12
U1 0
U2 3
PU AVES
PI SISLI
PA BUYUKDERE CAD 105-9, MECIDIYEKOY, SISLI, ISTANBUL 34394, TURKEY
SN 2149-2263
EI 2149-2271
J9 ANATOL J CARDIOL
JI Anat. J. Cardiol.
PD JAN
PY 2017
VL 17
IS 1
BP 66
EP 72
DI 10.14744/AnatolJCardiol.2016.6679
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA EK4JJ
UT WOS:000393892600014
PM 27271475
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Fuller, S
   Stephens, JM
AF Fuller, Scott
   Stephens, Jacqueline M.
TI Diosgenin, 4-Hydroxyisoleucine, and Fiber from Fenugreek: Mechanisms of
   Actions and Potential Effects on Metabolic Syndrome
SO ADVANCES IN NUTRITION
LA English
DT Review
DE fat cells; insulin action; botanicals; fenugreek; diosgenin;
   4-hydroxyisoleucine
ID TRIGONELLA-FOENUM-GRAECUM; FATTY LIVER-DISEASE; RENAL-FAILURE RATS;
   UNUSUAL AMINO-ACID; INSULIN-RESISTANCE; DIETARY FIBER; DIABETIC-RATS;
   ECTOPIC FAT; OXIDATIVE STRESS; CARDIOVASCULAR-DISEASE
AB Metabolic syndrome and its complications continue to rise in prevalence and show no signs of abating in the immediate future. Therefore, the search for effective treatments is a high priority in biomedical research. Products derived from botanicals have a time-honored history of use in the treatment of metabolic diseases including type 2 diabetes. Trigonella foenum-graecum, commonly known as fenugreek, is an annual herbaceous plant that has been a staple of traditional herbal medicine in many cultures. Although fenugreek has been studied in both clinical and basic research settings, questions remain about its efficacy and biologic mechanisms of action. Diosgenin, 4-hydroxyisoleucine, and the fiber component of the plant are the most intensively studied bioactive constituents present in fenugreek. These compounds have been demonstrated to exert beneficial effects on several physiologic markers including glucose tolerance, inflammation, insulin action, liver function, blood lipids, and cardiovascular health. Although insights into the molecular mechanisms underlying the favorable effects of fenugreek have been gained, we still do not have definitive evidence establishing its role as a therapeutic agent in metabolic disease. This review aims to summarize the currently available evidence on the physiologic effects of the 3 best-characterized bioactive compounds of fenugreek, with particular emphasis on biologic mechanisms of action relevant in the context of metabolic syndrome.
C1 [Fuller, Scott; Stephens, Jacqueline M.] Pennington Biomed Res Ctr, Baton Rouge, LA 70808 USA.
   [Stephens, Jacqueline M.] Louisiana State Univ, Dept Biol Sci, Baton Rouge, LA 70803 USA.
C3 Louisiana State University System; Louisiana State University;
   Pennington Biomedical Research Center; Louisiana State University
   System; Louisiana State University
RP Stephens, JM (corresponding author), Pennington Biomed Res Ctr, 6400 Perkins Rd, Baton Rouge, LA 70808 USA.
RI Fuller, Scott/GWM-5641-2022; Stephens, Jacqueline/R-5217-2018
FU postdoctoral training fellowship [T32 AT004094]
FX Supported by a postdoctoral training fellowship T32 AT004094 (to SF)
   awarded to Pennington Biomedical Research Center.
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NR 93
TC 90
Z9 99
U1 1
U2 39
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 2161-8313
EI 2156-5376
J9 ADV NUTR
JI Adv. Nutr.
PD MAR
PY 2015
VL 6
IS 2
BP 189
EP 197
DI 10.3945/an.114.007807
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA CE0GU
UT WOS:000351483300005
PM 25770257
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Barghchi, H
   Milkarizi, N
   Belyani, S
   Ostad, AN
   Askari, VR
   Rajabzadeh, F
   Goshayeshi, L
   Kheyrabadi, SYG
   Razavidarmian, M
   Dehnavi, Z
   Sobhani, SR
   Nematy, M
AF Barghchi, Hanieh
   Milkarizi, Narges
   Belyani, Saba
   Norouzian Ostad, Andisheh
   Askari, Vahid Reza
   Rajabzadeh, Farnood
   Goshayeshi, Ladan
   Ghelichi Kheyrabadi, Seyede Yegane
   Razavidarmian, Maryam
   Dehnavi, Zahra
   Sobhani, Seyyed Reza
   Nematy, Mohsen
TI Pomegranate (Punica granatum L.) peel extract ameliorates
   metabolic syndrome risk factors in patients with non-alcoholic fatty
   liver disease: a randomized double-blind clinical trial
SO NUTRITION JOURNAL
LA English
DT Article
DE Pomegranate Peel; Metabolic syndrome; Fatty liver; Dyslipidemia;
   Hypertension
ID OXIDATIVE STRESS; OBESE WOMEN; SUPPLEMENTATION; DIET; INFLAMMATION;
   POLYPHENOLS; ACCUMULATION; CELLS; NAFLD
AB IntroductionNon-alcoholic fatty liver disease (NAFLD) is a metabolic syndrome (MS)-related liver disorder that has an increasing prevalence. Thus, the aim of our study is to evaluate the effects of pomegranate peel extract (PP) supplementation on hepatic status and metabolic syndrome risk factors.MethodsIn phase one, the hydro-alcoholic extraction of the peel of 750 kg of pomegranate (Punica granatum L.) was performed by the soaking method. Then, in phase two, NAFLD patients received 1500 mg of placebo (n = 37) or pomegranate peel capsules (n = 39) with a 500-kcal deficit diet for 8 weeks. Gastrointestinal intolerance, dietary intake, lipid and glycemic profiles, systolic and diastolic blood pressure, body composition, insulin resistance indexes, and elastography-evaluated NAFLD changes were followed.ResultsThe mean age of participants was 43.1 & PLUSMN; 8.6 years (51.3% female). Following the intervention, the mean body weight (mean changes: -5.10 & PLUSMN; 2.30 kg), waist circumference (-7.57 & PLUSMN; 2.97 cm), body mass index (-1.82 & PLUSMN; 0.85 kg/m(2)), body fat index (-1.49 & PLUSMN; 0.86), and trunk fat (- 3.93 & PLUSMN; 3.07%), systolic (-0.63 & PLUSMN; 0.29 cmHg) and diastolic (-0.39 & PLUSMN; 0.19 cmHg) blood pressure, total cholesterol (-10.51 & PLUSMN; 0.77 mg/dl), triglyceride (-16.02 & PLUSMN; 1.7 mg/dl), low-density lipoprotein cholesterol (-9.33 & PLUSMN; 6.66 mg/dl; all P < 0.001), fat free mass (- 0.92 & PLUSMN; 0.90 kg; P < 0.003), and fasting blood sugar (-5.28 & PLUSMN; 1.36 mg/dl; P = 0.02) decreased significantly in PP in contrast to the placebo group in the raw model and when adjusted for confounders. Also, high-density lipoprotein cholesterol (5.10 & PLUSMN; 0.36 mg/dl), liver steatosis and stiffness (- 0.30 & PLUSMN; 0.17 and - 0.72 & PLUSMN; 0.35 kPa, respectively, all P < 0.001) improved in the PP group. However, fasting insulin (P = 0.81) and homeostatic model assessment for insulin resistance (HOMA-IR) (P = 0.93) were not significantly different when comparing two groups during the study in the raw and even adjusted models.ConclusionIn conclusion, 1500 mg pomegranate peel extract along with a weight-loss diet improved metabolic syndrome risk factors and reduced hepatic steatosis in patients with NAFLD after 8 weeks.
C1 [Barghchi, Hanieh; Norouzian Ostad, Andisheh; Ghelichi Kheyrabadi, Seyede Yegane; Dehnavi, Zahra; Sobhani, Seyyed Reza; Nematy, Mohsen] Mashhad Univ Med Sci, Fac Med, Dept Nutr, Mashhad, Iran.
   [Barghchi, Hanieh; Dehnavi, Zahra] Mashhad Univ Med Sci, Student Res Comm, Mashhad, Iran.
   [Milkarizi, Narges; Nematy, Mohsen] Mashhad Univ Med Sci, Metab Syndrome Res Ctr, Sch Med, Dept Nutr, Mashhad, Iran.
   [Belyani, Saba] North Khorasan Univ Med Sci, Student Res Comm, Bojnourd, Iran.
   [Askari, Vahid Reza] Mashhad Univ Med Sci, Pharmacol Res Ctr Med Plants, Mashhad, Iran.
   [Askari, Vahid Reza] Mashhad Univ Med Sci, Neurogenic Inflammat Res Ctr, Mashhad, Iran.
   [Rajabzadeh, Farnood] Islamic Azad Univ, Dept Radiol, Mashhad Med Sci Branch, Mashhad, Iran.
   [Goshayeshi, Ladan] Mashhad Univ Med Sci, Fac Med, Dept Gastroenterol & Hepatol, Mashhad, Iran.
   [Goshayeshi, Ladan] Mashhad Univ Med Sci, Gastroenterol & Hepatol Res Ctr, Mashhad, Iran.
   [Razavidarmian, Maryam] Varastegan Inst Med Sci, Dept Nutr Sci, Mashhad, Iran.
C3 Mashhad University of Medical Sciences; Mashhad University of Medical
   Sciences; Mashhad University of Medical Sciences; North Khorasan
   University of Medical Sciences; Mashhad University of Medical Sciences;
   Mashhad University of Medical Sciences; Islamic Azad University; Mashhad
   University of Medical Sciences; Mashhad University of Medical Sciences;
   Mashhad University of Medical Sciences
RP Nematy, M (corresponding author), Mashhad Univ Med Sci, Fac Med, Dept Nutr, Mashhad, Iran.; Nematy, M (corresponding author), Mashhad Univ Med Sci, Metab Syndrome Res Ctr, Sch Med, Dept Nutr, Mashhad, Iran.
EM nematym@mums.ac.ir
RI dehnavi, zahra/AAO-4256-2021; goshayeshi, ladan/AAQ-2715-2020; Sobhani,
   Seyyed/AAZ-8324-2020; rajabzadeh, farnood/ABA-8747-2021; Askari, Vahid
   Reza/ABB-8991-2020
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NR 84
TC 18
Z9 18
U1 0
U2 5
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1475-2891
J9 NUTR J
JI Nutr. J.
PD AUG 22
PY 2023
VL 22
IS 1
AR 40
DI 10.1186/s12937-023-00869-2
PG 17
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA P6ZS3
UT WOS:001052142900001
PM 37605174
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU El-Mehi, AE
   Faried, MA
AF El-Mehi, A. E.
   Faried, M. A.
TI Effect of high-fructose diet-induced metabolic syndrome on the
   pituitary-gonadal axis from adolescence through adulthood in male albino
   rats and the possible protective role of ginger extract. A biochemical,
   histological and immunohistochemical study
SO FOLIA MORPHOLOGICA
LA English
DT Article
DE high fructose; metabolic syndrome; ginger; pituitary; testis; oxidative
   stress; histopathology; immunohistochemistry
ID INDUCED REPRODUCTIVE TOXICITY; ZINGIBER-OFFICINALE; OXIDATIVE STRESS;
   ADIPOSE-TISSUE; CELL FUNCTION; DNA-DAMAGE; ANTIOXIDANT; AUTOPHAGY; MEN;
   SPERMATOGENESIS
AB Background: This work was designed to clarify, for the first time up to our knowledge, the effects of high-fructose diet (HFrD)-induced metabolic syndrome (MetS) on the pituitary-gonadal axis of adolescent male rats continuing through adulthood period and to evaluate the possible role of ginger extract in ameliorating these effects.
   Materials and methods: Forty 4-week-old male albino rats, treated for 8 weeks, were randomly divided into four equal groups; control (fed standard diet), ginger extract-treated (500 mg/kg once daily orally by gavage), HFrD-induced MetS (fed a diet containing 60% fructose), HFrD and ginger groups. The assessment methods included biochemical, histological and immunohistochemical studies.
   Results: High-fructose diet-fed rats exhibited a picture similar to MetS in the form of increased body weight and serum levels of glucose and insulin with an elevated HOMA-IR reflecting insulin resistance as well as dyslipidaemia. Lipid peroxidation (increased malondialdehyde) and oxidative stress (decreased superoxide dismutase) were implicated in this syndrome. This group exhibited a significant decrease in testicular weight and the levels of reproductive hormones (LH, FSH and testosterone). The pituitary gonadotrophs showed electron dense nuclei, large cytoplasmic vacuoles, destructed organelles in addition to decreased number of secretory granules. Furthermore, testicular specimens presented marked alterations. There were disorganised shrunken tubules with irregular basement membranes, reduced germinal epithelial thickness, vacuolations and degenerated mitochondria in the spermatogenic cells. Beclin 1 and proliferating cell nuclear antigen immunoexpressions were significantly downregulated with HFrD-induced MetS. Ginger extract supplementation proved to be a potent protective agent against these harmful effects through its antioxidant, hypoglycaemic, insulinotropic, androgenic and hypolipidaemic effects in addition to its ability to induce testicular autophagy.
   Conclusions: Consumption of HFrD induced MetS and proved to have harmful effects on the pituitary-testicular axis. Moreover, this work provided a new insight into the possible use of ginger extract to alleviate the main features of MetS and protect the pituitary-gonadal axis from the damaging effects of HFrD-induced MetS.
C1 [El-Mehi, A. E.; Faried, M. A.] Menoufia Univ, Fac Med, Anat & Embryol Dept, Al Minufya, Egypt.
C3 Egyptian Knowledge Bank (EKB); Menofia University
RP Faried, MA (corresponding author), Menoufia Univ, Fac Med, Anat & Embryol Dept, Al Minufya, Egypt.
EM manarfaried@med.menofia.edu.eg
RI El-Mehi, Abeer/AAG-6547-2021; Faried, Manar/AAY-3280-2021
OI El- Mehi, Abeer/0000-0002-3549-3162
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NR 91
TC 10
Z9 10
U1 0
U2 5
PU VIA MEDICA
PI GDANSK
PA UL SWIETOKRZYSKA 73, 80-180 GDANSK, POLAND
SN 0015-5659
EI 1644-3284
J9 FOLIA MORPHOL
JI Folia Morphol.
PY 2020
VL 79
IS 4
BP 690
EP 708
DI 10.5603/FM.a2019.0139
PG 19
WC Anatomy & Morphology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Anatomy & Morphology
GA PA9DW
UT WOS:000595928900004
PM 31886878
OA gold
DA 2025-06-11
ER

PT J
AU Padiya, R
   Khatua, TN
   Bagul, PK
   Kuncha, M
   Banerjee, SK
AF Padiya, Raju
   Khatua, Tarak N.
   Bagul, Pankaj K.
   Kuncha, Madhusudana
   Banerjee, Sanjay K.
TI Garlic improves insulin sensitivity and associated metabolic syndromes
   in fructose fed rats
SO NUTRITION & METABOLISM
LA English
DT Article
DE Allium sativum L.; garlic; Fructose; Diabetes; Metabolic syndrome;
   Nitric oxide; Hydrogen sulphide; oxidative stress
ID HYDROGEN-SULFIDE; WEIGHT-GAIN; RESISTANCE; HYPERTENSION; ANTIOXIDANTS;
   EPIDEMIC; ALLICIN; OXIDE; OIL
AB Background: Type 2 diabetes mellitus, characterized by peripheral insulin resistance, is a major lifestyle disorder of the 21(st) Century. Raw garlic homogenate has been reported to reduce plasma glucose levels in animal models of type 1 diabetes mellitus. However, no specific studies have been conducted to evaluate the effect of raw garlic on insulin resistance or type 2 diabetes mellitus. This study was designed to investigate the effect of raw garlic on fructose induced insulin resistance, associated metabolic syndrome and oxidative stress in diabetic rats.
   Methods: Male Sprague Dawley rats weighing 200-250 gm body weight were divided into 3 groups (n = 7 per group) and fed diet containing 65% cornstarch (Control group) and 65% fructose (Diabetic group) for 8 weeks. The third group (Dia+Garl group) was fed both 65% fructose and raw garlic homogenate (250 mg/kg/day) for 8 weeks. Whole garlic cloves were homogenized with water to make a fresh paste each day.
   Results: At the end of 8 weeks, serum glucose, insulin, triglyceride and uric acid levels, as well as insulin resistance, as measured by glucose tolerance test, were significantly (p < 0.01) increased in fructose fed rats (Diabetic group) when compared to the cornstarch fed (Control) rats. Administration of raw garlic to fructose fed rats (Dia+Garl group) significantly (p < 0.05) reduced serum glucose, insulin, triglyceride and uric acid levels, as well as insulin resistance when compared with fructose fed rats. Garlic also normalised the increased serum levels of nitric oxide (NO) and decreased levels of hydrogen sulphide (H2S) after fructose feeding. Although body weight gain and serum glycated haemoglobin levels of fructose fed rats (Diabetic group) were not significantly different from control rats, significant (p < 0.05) reduction of these parameters was observed in fructose fed rats after garlic administration (Dia+Garl group). Significant (p < 0.05) increase in TBARS and decrease in GSH was observed in diabetic liver. Catalase was not significantly affected in any of the groups. Administration of raw garlic homogenate normalised both hepatic TBARS and GSH levels.
   Conclusions: Our study demonstrates that raw garlic homogenate is effective in improving insulin sensitivity while attenuating metabolic syndrome and oxidative stress in fructose-fed rats.
C1 [Padiya, Raju; Khatua, Tarak N.; Bagul, Pankaj K.; Kuncha, Madhusudana; Banerjee, Sanjay K.] Indian Inst Chem Technol, Div Pharmacol & Chem Biol, Hyderabad 500607, Andhra Pradesh, India.
C3 Council of Scientific & Industrial Research (CSIR) - India; CSIR -
   Indian Institute of Chemical Technology (IICT)
RP Banerjee, SK (corresponding author), Indian Inst Chem Technol, Div Pharmacol & Chem Biol, Hyderabad 500607, Andhra Pradesh, India.
EM skbanerjee@iict.res.in
RI Dr. Pankaj K. Bagul, M.S/I-3867-2012
OI , Raju Padiya/0000-0002-9772-9118; Banerjee, Sanjay/0000-0002-0008-0480;
   , Tarak Nath Khatua/0009-0002-0797-5137; Banerjee, Sanjay
   k/0000-0002-0044-0984
FU Department of Biotechnology (DBT); Indian Council of Medical Research
   (ICMR); Council of Scientific and Industrial Research (CSIR), Govt. of
   India; IICT institute
FX Financial support was provided by Ramalingaswami Fellowship fund (SKB)
   from Department of Biotechnology (DBT), Junior Research Fellowship (RP)
   from Indian Council of Medical Research (ICMR), and Senior Research
   Fellowship (TNK) from Council of Scientific and Industrial Research
   (CSIR), Govt. of India and IICT institute fund. We wish to thank Dr J S
   Yadav, Director, IICT, Hyderabad for providing all kind of support for
   this work and gratefully acknowledge Dr Mohua Maulik for her suggestions
   and critical review of the manuscript.
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NR 43
TC 108
Z9 116
U1 0
U2 29
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1743-7075
J9 NUTR METAB
JI Nutr. Metab.
PD JUL 27
PY 2011
VL 8
AR 53
DI 10.1186/1743-7075-8-53
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 816ML
UT WOS:000294605000001
PM 21794123
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Konikowska, K
   Bombala, W
   Szuba, A
   Rózanska, D
   Regulska-Ilow, B
AF Konikowska, Klaudia
   Bombala, Wojciech
   Szuba, Andrzej
   Rozanska, Dorota
   Regulska-Ilow, Bozena
TI Metabolic Syndrome Is Associated with Low Diet Quality Assessed by the
   Healthy Eating Index-2015 (HEI-2015) and Low Concentrations of
   High-Density Lipoprotein Cholesterol
SO BIOMEDICINES
LA English
DT Article
DE metabolic syndrome; diet; diet quality; nutrition; HEI-2015
ID CARDIOVASCULAR RISK-FACTORS; CORONARY-HEART-DISEASE; FATTY-ACIDS;
   WEIGHT-LOSS; METAANALYSIS; MANAGEMENT; PROTEIN; STRESS; IMPACT; ADULTS
AB Presenting diet quality of patients with metabolic syndrome (MetS), using a holistic approach is more useful than investigating dietary individual components, but there is still a small amount of research in this area. The aim of this study assessed the diet quality, as measured by the HEI-2015, of MetS patients compared to healthy individuals. The study and control group consisted of 215 patients with MetS and 320 people without MetS, respectively. A nutritional analysis using a semi-quantitative food frequency questionnaire was used to evaluate the nutritional habits in the study and control group. Total HEI-2015 scores were significantly lower in MetS subjects than in those in the control group (65.04 +/- 9.71 vs. 66.75 +/- 8.88) and the quality of women's diets was better than the quality of men's diet (66.83 +/- 8.99 vs. 64.75 +/- 9.57). We also observed that low HDL-c concentration increased the risk of MetS in the general population the most. Across the population, there was a weak positive correlation between HDL-c concentrations and total HEI-2015 scores and a weak negative correlation between mean waist circumference values and total HEI-2015 scores. HDL-c concentrations may be a key factor in the prevention of MetS and appropriate therapeutic management to increase HDL-c levels may be of key importance in patients diagnosed with MetS.
C1 [Konikowska, Klaudia; Rozanska, Dorota; Regulska-Ilow, Bozena] Wroclaw Med Univ, Dept Dietet, Borowska St 211, PL-50556 Wroclaw, Poland.
   [Bombala, Wojciech] Wroclaw Med Univ, Stat Anal Ctr, Marcinkowski St 2-6, PL-50368 Wroclaw, Poland.
   [Szuba, Andrzej] Wroclaw Med Univ, Dept Angiol Hypertens & Diabetol, Borowska St 213, PL-50556 Wroclaw, Poland.
C3 Wroclaw Medical University; Wroclaw Medical University; Wroclaw Medical
   University
RP Konikowska, K (corresponding author), Wroclaw Med Univ, Dept Dietet, Borowska St 211, PL-50556 Wroclaw, Poland.
EM klaudia.konikowska@umw.edu.pl
RI Różańska, Dorota/ABD-3220-2021; Szuba, Andrzej/AAY-1162-2020;
   Regulska-Ilow, Bożena/ABD-3301-2021; Rozanska, Dorota/S-5239-2018;
   Konikowska, Klaudia/AAZ-1828-2021
OI Regulska-Ilow, Bozena/0000-0002-5941-1715; Szuba,
   Andrzej/0000-0002-7555-6201; Rozanska, Dorota/0000-0002-0561-2749;
   Konikowska, Klaudia/0000-0003-0111-7617
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NR 73
TC 15
Z9 16
U1 0
U2 11
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2227-9059
J9 BIOMEDICINES
JI Biomedicines
PD OCT
PY 2022
VL 10
IS 10
AR 2487
DI 10.3390/biomedicines10102487
PG 17
WC Biochemistry & Molecular Biology; Medicine, Research & Experimental;
   Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Research & Experimental Medicine;
   Pharmacology & Pharmacy
GA 5O3RW
UT WOS:000872395800001
PM 36289749
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Peng, XM
   Huang, JJ
   Xia, SS
   Yang, Y
   Dong, K
AF Peng, Xuemin
   Huang, Jiaojiao
   Xia, Sanshan
   Yang, Yan
   Dong, Kun
TI Association of leukocyte telomere length with metabolic syndrome in type
   2 diabetes mellitus
SO JOURNAL OF RESEARCH IN MEDICAL SCIENCES
LA English
DT Article
DE Metabolic syndrome; telomere; type 2 diabetes mellitus
ID OXIDATIVE STRESS; PREVALENCE; RISK; MARKERS; OBESITY; DISEASE
AB Background: Leukocyte telomere length (LTL) has been revealed to be associated with aging-related diseases such as metabolic syndrome (MetS) and Type 2 diabetes mellitus (T2DM). We aimed to investigate the correlation of LTL with MetS and its components in T2DM patients in this cross-sectional study. Materials and Methods: A total of 344 T2DM patients were enrolled into this study. LTL was measured by Southern blot-based terminal restriction fragment length analysis. MetS was clinically defined by 2007 Chinese Guidelines on Prevention and Treatment of Dyslipidemia in Adults. Results: Of 344 T2DM patients, 53% had MetS. T2DM patients with MetS had significantly longer LTL than those without MetS (6451.95 +/- 51.10 base pairs vs. 6076.13 +/- 55.13 base pairs, P < 0.001), especially when T2DM patients had poor glycemic control (hemoglobin A1c >= 7%). Meanwhile, the trend of longer LTL was associated with the increased components of MetS in T2DM patient. Finally, LTL had a significant association with MetS (odds ratio [OR]: 2.096, 95% confidence interval [CI] 1.337-3.285, P = 0.001), low levels of high-density lipoprotein-cholesterol (HDL-C) (OR: 2.412, 95% CI 1.350-4.308, P = 0.003) in T2DM patients. Conclusion: T2DM patients with MetS had a significantly longer LTL than those without MetS. The longer LTL was especially evident in T2DM patients with poor glycemic control. Longer LTL was positively associated with MetS, particularly low levels of HDL-C in T2DM patients.
C1 [Peng, Xuemin; Huang, Jiaojiao; Xia, Sanshan; Yang, Yan; Dong, Kun] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Endocrinol, Wuhan, Hubei, Peoples R China.
C3 Huazhong University of Science & Technology
RP Dong, K (corresponding author), 1095 Jiefang Ave, Wuhan 430030, Hubei, Peoples R China.
EM kundong2019@hotmail.com
FU National Natural Science Foundation of China [81670754, 81600661]
FX This study was financially supported by grants from the National Natural
   Science Foundation of China (Nos. 81670754 and 81600661).
CR Anonymous, 2007, Zhonghua Xinxueguanbing Zazhi, V35, P390
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NR 32
TC 6
Z9 7
U1 0
U2 11
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, Maharashtra, INDIA
SN 1735-1995
EI 1735-7136
J9 J RES MED SCI
JI J. Res. Med. Sci.
PD JAN-DEC
PY 2021
VL 26
IS 1
DI 10.4103/jrms.JRMS_793_20
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA TX6UH
UT WOS:000683224600001
PM 34484375
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Guo, XX
   Wang, O
   Wang, Y
   Wang, K
   Ji, BP
   Zhou, F
AF Guo, Xiaoxuan
   Wang, Ou
   Wang, Yong
   Wang, Kai
   Ji, Baoping
   Zhou, Feng
TI Phenolic acids alleviate high-fat and high-fructose diet-induced
   metabolic disorders in rats
SO JOURNAL OF FOOD BIOCHEMISTRY
LA English
DT Article
DE high-fructose and high-fat diet; metabolic syndrome; phenolic acids
ID HEPATIC STEATOSIS; CAFFEIC ACID; MITOCHONDRIAL DYSFUNCTION; ANTIOXIDANT
   PROPERTIES; PROTOCATECHUIC ACID; LIPID-ACCUMULATION; INSULIN-RESISTANCE;
   OXIDATIVE STRESS; CHLOROGENIC ACID; SKELETAL-MUSCLE
AB Phenolic acids are naturally occurring compounds with meritorious physiological activities. The purpose of this study was to compare the ameliorative effects of six common phenolic acids on diet-induced metabolic syndrome (MS) in rats. SD rats were fed with high-fat and high-fructose diet supplemented with equimolar concentration of individual phenolic acids for 13 weeks. Results showed that different phenolic acids ameliorated MS through different ways. Compared with other phenolic acids, caffeic acid exerted more comprehensive effect in alleviating MS, with significant effects in attenuating hyperlipidemia, elevating glucose tolerance, improving antioxidant status, and normalizing hepatic functions. Ellagic acid exhibited good performance in hypolipidemia, anti-inflammation, and reducing visceral fat. Gallic acid and -coumaric acid showed marked effects in regulating liver steatosis, while chlorogenic acid exhibited potential hepatic protective and anti-inflammatory abilities. These results will benefit the application of these phenolic acids in the development of functional food for MS population.
   Practical applicationsThe high morbidity of metabolic syndrome (MS) has driven people to seek for natural and safe compounds to maintain optimal health. Different phenolic acids were shown to ameliorate MS through different ways, which provides experimental basis for developing combinations or formulas of phenolic acids with more comprehensive effects. Conversely, caffeic acid showed relatively better effects in attenuating features of metabolic disorders, and was suggested for the future development of functional foods for the population with MS.
C1 [Guo, Xiaoxuan; Ji, Baoping; Zhou, Feng] China Agr Univ, Beijing Key Lab Funct Food Plant Resources, Coll Food Sci & Nutr Engn, Beijing 100083, Peoples R China.
   [Wang, Ou] Chinese Ctr Dis Control & Prevent, Natl Inst Nutr & Hlth, Beijing 100050, Peoples R China.
   [Wang, Yong] Acad State Adm Grain, Beijing 100037, Peoples R China.
   [Wang, Kai] Chinese Acad Agr Sci, Inst Apicultural Res, Beijing 100093, Peoples R China.
C3 China Agricultural University; Chinese Center for Disease Control &
   Prevention; Institute of Apicultural Research, CAAS; Chinese Academy of
   Agricultural Sciences
RP Zhou, F (corresponding author), China Agr Univ, POB 294,17 Tsinghua East Rd, Beijing 100083, Peoples R China.
EM zf@cau.edu.cn
RI Wang, Ou/AAE-1806-2022; Wang, Kai/Q-6434-2018
OI Wang, Kai/0000-0003-0553-5293
FU National Natural Science Foundation of China [31571831]
FX National Natural Science Foundation of China, Grant/Award Number:
   31571831
CR [Anonymous], CAN J PHYSL PHARM
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   Zimmet P, 2001, NATURE, V414, P782, DOI 10.1038/414782a
NR 47
TC 12
Z9 12
U1 3
U2 51
PU WILEY-HINDAWI
PI LONDON
PA ADAM HOUSE, 3RD FL, 1 FITZROY SQ, LONDON, WIT 5HE, ENGLAND
SN 0145-8884
EI 1745-4514
J9 J FOOD BIOCHEM
JI J. Food Biochem.
PD DEC
PY 2017
VL 41
IS 6
AR e12419
DI 10.1111/jfbc.12419
PG 10
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA FO8FS
UT WOS:000417120500018
OA gold
DA 2025-06-11
ER

PT J
AU Gómez-Díaz, RA
   García-Bello, JA
   Mondragón-González, R
   Díaz-Flores, M
   Valladares-Salgado, A
   Gallardo, JM
   Talavera, JO
   Wacher, NH
AF Gomez-Diaz, Rita A.
   Antonio Garcia-Bello, Juan
   Mondragon-Gonzalez, Rafael
   Diaz-Flores, Margarita
   Valladares-Salgado, Adan
   Manuel Gallardo, Juan
   Talavera, Juan O.
   Wacher, Niels H.
TI Metabolic Syndrome in Children with Chronic Kidney Disease: PON1 and
   Treatment Modality
SO ARCHIVES OF MEDICAL RESEARCH
LA English
DT Article
DE Paraoxonase-1; SOD; PON1/HDL-cholesterol; Metabolic syndrome in
   children; CKD treatment modality
ID CHRONIC-RENAL-FAILURE; OXIDATIVE STRESS; PARAOXONASE-1 ACTIVITY;
   RISK-FACTORS; ADOLESCENTS; MORTALITY; OBESITY; HYPERLIPIDEMIA;
   INTERLEUKIN-6; POPULATION
AB Background and Aims. We undertook this study to evaluate the relationship between PON1, SOD and metabolic syndrome (MetS) in pediatric patients undergoing peritoneal dialysis, hemodialysis and patients in early stages of CKD.
   Methods. We carried out an analytical cross-sectional study of 134 children 6-17 years old. We registered anthropometric variables, vital signs, basic biochemical parameters, intact PTH (iPTH), high sensitivity CRP (hs-CRP), paraoxonase-1; SOD; PON1/HDL-cholesterol and homocysteine. For statistical analyses we used t test, Mann Whitney U test, x(2), Fisher exact test, linear or logistic regression models, using SPSS v.16.0. p values <0.05 were considered as significant.
   Results. There were 66 (49.3%) females; 39 (29.1%) had CKD stages 2-4 (predialysis), 42 (31.3%) on hemodialysis (HD) and 53 (39.6%) on automated peritoneal dialysis (PD). Time from diagnosis was 26 months. Significant differences were observed in mean, systolic and diastolic blood pressure, C-peptide, triglycerides, and HDL-cholesterol as well as PON1/HDL-cholesterol ratio and SOD.
   Conclusions. This study demonstrates that PON1 and SOD may be predictors for the presence of MetS in pediatric patients under treatment with peritoneal dialysis. The positive correlation observed in PON1/HDL-cholesterol ratio may reflect the protector effect of HDL-cholesterol in patients with CKD according with the modality of treatment. (C) 2013 IMSS. Published by Elsevier Inc.
C1 [Gomez-Diaz, Rita A.; Mondragon-Gonzalez, Rafael; Talavera, Juan O.; Wacher, Niels H.] UMAE Specialty Hosp, Ctr Med Nacl Siglo 21, IMSS, Med Res Unit Clin Epidemiol, Mexico City 06725, DF, Mexico.
   [Antonio Garcia-Bello, Juan] UMAE Gen Hosp Med Ctr La Raza, Nephrol Servis, IMSS, Mexico City, DF, Mexico.
   [Diaz-Flores, Margarita; Valladares-Salgado, Adan] UMAE Specialty Hosp, Ctr Med Nacl Siglo 21, IMSS, Med Res Unit Biochem, Mexico City 06725, DF, Mexico.
   [Manuel Gallardo, Juan] UMAE Specialty Hosp, Ctr Med Nacl Siglo 21, IMSS, Dis Res Unit Nephrol, Mexico City 06725, DF, Mexico.
C3 Instituto Mexicano del Seguro Social; Instituto Mexicano del Seguro
   Social; Instituto Mexicano del Seguro Social; Instituto Mexicano del
   Seguro Social
RP Gómez-Díaz, RA (corresponding author), UMAE Specialty Hosp, Ctr Med Nacl Siglo 21, IMSS, Med Res Unit Clin Epidemiol, Av Cuauhtemoc 330, Mexico City 06725, DF, Mexico.
EM ritagomezdiaz@netscape.net
RI Mondragon, Rafael/AAD-8567-2020; GALLARDO, Juan/HGF-1360-2022;
   gomez-diaz, rita/AAS-4030-2021; García, Antonio/HTO-1996-2023
OI Mondragon, Rafael/0000-0002-5673-3540; wacher,
   niels/0000-0002-7717-6704; DIAZ-FLORES, MARGARITA/0000-0001-9764-2701;
   GALLARDO, Juan Manuel/0000-0001-8833-4651; gomez-diaz,
   rita/0000-0002-2191-4931
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NR 35
TC 4
Z9 4
U1 0
U2 8
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0188-4409
EI 1873-5487
J9 ARCH MED RES
JI Arch. Med. Res.
PD NOV
PY 2013
VL 44
IS 8
SI SI
BP 645
EP 649
DI 10.1016/j.arcmed.2013.10.014
PG 5
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 281DM
UT WOS:000329080100012
PM 24211756
DA 2025-06-11
ER

PT J
AU Palmieri, VO
   Coppola, B
   Grattagliano, I
   Casieri, V
   Cardinale, G
   Portincasa, P
   Palasciano, G
   Di Serio, F
AF Palmieri, Vincenzo O.
   Coppola, Brigida
   Grattagliano, Ignazio
   Casieri, Valentina
   Cardinale, Giovanna
   Portincasa, Piero
   Palasciano, Giuseppe
   Di Serio, Francesca
TI Oxidized LDL Receptor 1 gene polymorphism in patients with Metabolic
   Syndrome
SO EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
LA English
DT Article
DE Insulin resistance; LOX-1 polymorphism; Metabolic Syndrome;
   microalbuminuria; Thiobarbituric acid; Thioredoxin
ID LOW-DENSITY-LIPOPROTEIN; ACUTE MYOCARDIAL-INFARCTION;
   CORONARY-ARTERY-DISEASE; LECTIN-LIKE; LOX-1 EXPRESSION; OLR1 GENE;
   MONOCYTE ADHESION; ENDOTHELIAL-CELLS; ATHEROSCLEROSIS; RISK
AB Aims The lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1), encoded by the OLR1 gene, has been implicated in the pathogenesis of atherosclerosis. We therefore evaluated the genotyping of OLR1 gene in a sample of 55 patients with
   Metabolic Syndrome, a clinical condition characterized by a high cardiovascular risk. Methods and Patients The genotyping of the LOX-1 was performed by polymerase chain reaction (PCR) analysis of the IVS4-14 A > G OLR1 polymorphism embedded within the OLR1 Linkage Disequilibrium block. Patients were assessed for routine serum parameters, microalbuminuria, insulin resistance (HOMA) and oxidative stress (thiobarbituric acid reactive substances, TBARs and thioredoxin).
   Results The allele or genotype distribution of the OLR1 IVS4-14 A > G was not statistically different between MS and controls subjects. A positive association was found between IVS4-14 GG genotype, microalbuminuria and fasting glycaemia as well as a higher frequency of type 2 diabetes, elevated microalbuminuria, fasting serum glucose and HOMA index in the same subjects. Thioredoxin values were higher in patients with MS but did not differ in relation to OLR1 IVS4-14 A > G genotype. The TBARs/Cholesterol ratio was higher in MS both in IVS4-14 GG and in IVS4-14 AG.
   Conclusion IVS4-14 GG genotype seems to be related to glucose metabolism disturbance, elevated insulin level and lipid peroxidation in patients with MS.
C1 [Palmieri, Vincenzo O.; Grattagliano, Ignazio; Cardinale, Giovanna; Portincasa, Piero; Palasciano, Giuseppe] Univ Bari, Clin Med A Murri, Dept Biomed Sci & Human Oncol, Bari, Italy.
   [Coppola, Brigida; Casieri, Valentina; Di Serio, Francesca] Policlin Univ Hosp, Dept Clin Pathol 1, Bari, Italy.
C3 Universita degli Studi di Bari Aldo Moro; Universita degli Studi di Bari
   Aldo Moro
RP Palmieri, VO (corresponding author), Univ Bari Policlin, Clin Med A Murri, Dept Biomed Sci & Human Oncol, I-70124 Bari, Italy.
EM v.o.palmieri@gmail.com
RI portincasa, piero/J-7245-2018
OI Palasciano, Giuseppe/0000-0002-0396-488X; palmieri, vincenzo
   ostilio/0000-0002-7649-6028; portincasa, piero/0000-0001-5359-1471
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NR 33
TC 14
Z9 15
U1 0
U2 5
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0014-2972
J9 EUR J CLIN INVEST
JI Eur. J. Clin. Invest.
PD JAN
PY 2013
VL 43
IS 1
BP 41
EP 48
DI 10.1111/eci.12013
PG 8
WC Medicine, General & Internal; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Research & Experimental Medicine
GA 074MK
UT WOS:000313816400006
PM 23134583
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Yesilova, Y
   Turan, E
   Ucmak, D
   Selek, S
   Yavuz, BH
   Tanrikulu, O
AF Yesilova, Yavuz
   Turan, Enver
   Ucmak, Derya
   Selek, Sahabettin
   Yavuz, Brahim Halil
   Tanrikulu, Osman
TI Reduced serum paraoxonase-1 levels in vitiligo: further evidence of
   oxidative stress
SO REDOX REPORT
LA English
DT Article
DE Vitiligo; Paraoxonase 1; Oxidative stress index
ID GLUTATHIONE-PEROXIDASE ACTIVITIES; TOTAL ANTIOXIDANT RESPONSE;
   QUALITY-OF-LIFE; LIPID-PEROXIDATION; ACTIVE VITILIGO;
   SUPEROXIDE-DISMUTASE; METABOLIC SYNDROME; BEHCETS-DISEASE; SELENIUM
   LEVELS; TISSUE-LEVEL
AB Vitiligo is a common disorder that results in depigmented areas of the skin. The pathogenesis of the disease remains unclear, but oxidative stress is one suggested cause. Oxidative stress may be induced by increasing the generation of reactive oxygen species and other free radicals. The generation of reactive oxygen species is known to be associated with a decrease in antioxidant levels. This study examined oxidative stress index in active lesions of generalized vitiligo patients. We analysed serum levels of paraoxonase 1, arylesterase, catalase, ceruloplasmin, total antioxidant capacity, and oxidative stress index in patients with active lesions of generalized vitiligo, as well as in matched, healthy controls. Serum oxidants and oxidative stress indexes were higher, and serum antioxidants were lower, in vitiligo patients compared with healthy controls. Our findings suggest that oxidative stress may play an important role in the pathogenesis of vitiligo. Paraoxonase 1 can be used as an indicator in determining oxidative stress existent in the pathogenesis of vitiligo diseases.
C1 [Yesilova, Yavuz; Turan, Enver; Tanrikulu, Osman] Harran Univ, Dept Dermatol, Fac Med, TR-63200 Sanliurfa, Turkey.
   [Ucmak, Derya] Dicle Univ, Sch Med, Dept Dermatol, Diyarbakir, Turkey.
   [Selek, Sahabettin] Harran Univ, Dept Biochem, Fac Med, TR-63200 Sanliurfa, Turkey.
   [Yavuz, Brahim Halil] Sivas Numune Hosp, Dermatol Clin, Sivas, Turkey.
C3 Harran University; Dicle University; Harran University; Sivas Numune
   Hospital
RP Yesilova, Y (corresponding author), Harran Univ, Dept Dermatol, Fac Med, TR-63200 Sanliurfa, Turkey.
EM yavuzyesilova@gmail.com
RI Turan, Eylem/IQW-5912-2023; Yeşilova, Abdullah/AAX-2682-2020; SELEK,
   Sahabettin/N-9323-2019
OI SELEK, Sahabettin/0000-0003-1235-3957; yavuz, ibrahim
   halil/0000-0003-0819-2871
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NR 40
TC 13
Z9 13
U1 0
U2 14
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1351-0002
EI 1743-2928
J9 REDOX REP
JI Redox Rep.
PD SEP
PY 2012
VL 17
IS 5
BP 214
EP 218
DI 10.1179/1351000212Y.0000000025
PG 5
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 022PL
UT WOS:000309971800006
PM 23068968
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Malarvizhi, R
   Mani, S
   Sali, VK
   Bhardwaj, M
   Vasanthi, HR
AF R., Malarvizhi
   Mani, Sugumar
   Sali, Veeresh K.
   Bhardwaj, Meenakshi
   Vasanthi, Hannah R.
TI Macrotyloma uniflorum a plant food alleviates the metabolic
   syndrome through modulation of adipokines and PPARs
SO JOURNAL OF FOOD BIOCHEMISTRY
LA English
DT Article
DE AMPK; brown fat; M; uniflorum; metabolic syndrome; PPAR
ID DIET-INDUCED OBESITY; HORSE GRAM; FATTY-ACID; RAT MODEL; PHYTOCHEMICALS;
   HYPERTENSION; ADIPONECTIN; EXTRACTION; DISEASE; PROTEIN
AB A sedentary lifestyle combined with the intake of high-calorie diet has been the paramount cause of metabolic syndrome (MS) which is now a serious concern of public health worldwide as it involves the coexistence of hypertension, hyperlipidemia, glucose intolerance, and obesity. Hence, identifying a suitable strategy to overcome the worldwide menace of MS is imperative. Macrotyloma uniflorum a lesser known legume is highly nutritious and notable for its ethano-medicinal potential. Herein, the influence of M. uniflorum in high-fat dietinduced metabolic changes in a rodent model of metabolic syndrome was evaluated. Serum levels of glucose, total cholesterol, triglycerides, VLDL-c, and bodyweight were decreased, whereas HDL-c was increased in M. uniflorum-treated MS rats. The protein expression (AMPK-alpha, PPAR-alpha, and PPAR-gamma) and gene expression (leptin, adiponectin, resistin, UCP2, NF-kappa B, and IL-6) results are impressive to highlight that M. uniflorum modulates the pathological conditions of MS and proves to be cardioprotective. Furthermore, the histopathological analysis confirmed the pathological changes and substantiates the influence of M. uniflorum to overcome MS. The HPLC and GC (MS) profiling reveals the presence of an array of polyphenols such as rutin (694.61 mu g/g), catechin (500.12 mu g/g), epicatechin (158.10 mu g/g), gallic acid (17.98 mu g/g), ferulic acid (10.911 mu g/g), daidzein (6.51 mu g/g), and PUFA, respectively, which probably exhibits the therapeutic effect on MS and associated complications by modulating lipid metabolism and adipogenesis.
   Practical applications Metabolic disorders like CVD and diabetes are leading cause of mortality and morbidity worldwide. With emerging issues on adverse effects of modern drugs, the emphasis on "Food is Medicine and Medicine as Food" has taken dramatic dimensions in the healthcare sector. Therefore, nutraceuticals are in great demand in the developed world off late. Legumes, are potent elements in a balanced diet next to cereals. Exploring the medicinal properties of legumes could bring a revolution in public health and nutraceutical industries. This study scientifically validated the phytochemicals in M. uniflorum for its functional potential in the management of Metabolic Syndrome (MS). This study would help the nutraceutical industries to develop functional foods using M. uniflorum seeds to make porridges and soups or nutraceutical supplements with the bioflavonoids isolated from M. uniflorum for the management of metabolic disorders by mitigating hyperlipidemia, oxidative stress, and inflammation.
C1 [R., Malarvizhi; Mani, Sugumar; Sali, Veeresh K.; Bhardwaj, Meenakshi; Vasanthi, Hannah R.] Pondicherry Univ, Sch Life Sci, Dept Biotechnol, Nat Prod Res Lab, Pondicherry, India.
C3 Pondicherry University
RP Vasanthi, HR (corresponding author), Pondicherry Univ, Sch Life Sci, Dept Biotechnol, Pondicherry 605014, India.
EM hrvasanthi@gmail.com
RI VASANTHI, HANNAH/JPA-2689-2023
OI Bhardwaj, Meenakshi/0000-0003-4771-5145; Vasanthi, Hannah
   Rachel/0000-0001-6804-8332
FU DST-FIST grant; UGC-SAP grant; UGC fellowship from Pondicherry
   University
FX The authors acknowledge the DST-FIST and UGC-SAP grants for developing
   infrastructural facilities in the Department of Biotechnology,
   Pondicherry University for executing the present study, and the UGC
   fellowship from Pondicherry University to the first author. The
   histopathological and microphotographs prepared in CIDRF of Mahatma
   Gandhi Medical College and Research Institute, Puducherry are
   acknowledged with a special mention.
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NR 53
TC 6
Z9 6
U1 2
U2 10
PU WILEY-HINDAWI
PI LONDON
PA ADAM HOUSE, 3RD FL, 1 FITZROY SQ, LONDON, WIT 5HE, ENGLAND
SN 0145-8884
EI 1745-4514
J9 J FOOD BIOCHEM
JI J. Food Biochem.
PD FEB
PY 2021
VL 45
IS 2
AR e13595
DI 10.1111/jfbc.13595
EA DEC 2020
PG 14
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA QL9IC
UT WOS:000601091200001
PM 33368458
OA gold
DA 2025-06-11
ER

PT J
AU Kharouf, F
   Gladman, DD
AF Kharouf, Fadi
   Gladman, Dafna D.
TI Advances in the management of psoriatic arthritis in adults
SO BMJ-BRITISH MEDICAL JOURNAL
LA English
DT Review
ID PLACEBO-CONTROLLED TRIAL; BIOLOGIC-NAIVE PATIENTS; DOUBLE-BLIND;
   MONOCLONAL-ANTIBODY; INADEQUATE RESPONSE; DISEASE-ACTIVITY; PHASE-III;
   PERIPHERAL ARTHRITIS; CLINICAL ENTHESITIS; EXERCISE PROGRAM
AB Psoriatic arthritis is an inflammatory arthritis that affects around 30% of patients with psoriasis. The disease spectrum includes peripheral arthritis, enthesitis, tenosynovitis, dactylitis, axial involvement, and skin and nail psoriasis in most patients. In addition to the cutaneous and musculoskeletal manifestations, several comorbidities can complicate the disease course, including cardiovascular disease, diabetes mellitus, metabolic syndrome, gout, anxiety, and depression. The management of patients with psoriatic arthritis begins with a careful assessment of the skin and joints and screening for comorbidities. This review describes the assessment tools and outcome measures used in the evaluation of patients with psoriatic arthritis. It summarizes the approach to therapy, including non-medicinal interventions such as education, lifestyle changes, physiotherapy, and occupational therapy. It discusses the evidence on pharmacologic treatments, including drugs used for symptomatic relief such as non-steroidal anti-inflammatory drugs, and those used to control the disease process; this last group comprises conventional synthetic disease modifying anti-rheumatic drugs (DMARDs), including methotrexate, leflunomide, and sulfasalazine, and biologic and targeted DMARDs, including anti-tumor necrosis factor (TNF alpha), anti-interleukin-17 (IL-17), anti-IL-12/23, and anti-IL-23 agents, as well as Janus kinase (JAK) inhibitors and phosphodiesterase 4 (PDE4) antagonists. Although these drugs are usually tailored to the clinical profile of the patient, biomarkers predictive of response to therapy are needed so that a more personalized approach can be followed.
C1 [Kharouf, Fadi; Gladman, Dafna D.] Univ Toronto, Univ Hlth Network, Toronto Western Hosp, Psoriat Arthrit Program, Toronto, ON, Canada.
   [Kharouf, Fadi; Gladman, Dafna D.] Toronto Western Hosp, Gladman Krembil Psoriat Dis Program, Toronto, ON, Canada.
C3 University of Toronto; University Health Network Toronto; University of
   Toronto; University Health Network Toronto
RP Gladman, DD (corresponding author), Univ Toronto, Univ Hlth Network, Toronto Western Hosp, Psoriat Arthrit Program, Toronto, ON, Canada.; Gladman, DD (corresponding author), Toronto Western Hosp, Gladman Krembil Psoriat Dis Program, Toronto, ON, Canada.
EM dafna.gladman@utoronto.ca
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NR 138
TC 3
Z9 3
U1 3
U2 3
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 0959-535X
EI 1756-1833
J9 BMJ-BRIT MED J
JI BMJ-British Medical Journal
PD NOV 21
PY 2024
VL 387
AR e081860
DI 10.1136/bmj-2024-081860
PG 15
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA N7N6Q
UT WOS:001366163200010
PM 39572047
OA Bronze
DA 2025-06-11
ER

PT J
AU Bashir, A
   Duseja, A
   De, AR
   Mehta, M
   Tiwari, P
AF Bashir, Aamir
   Duseja, Ajay
   De, Arka
   Mehta, Manu
   Tiwari, Pramil
TI Non-alcoholic fatty liver disease development: A multifactorial
   pathogenic phenomena
SO LIVER RESEARCH
LA English
DT Review
DE Metabolic syndrome (MS); Non-alcoholic fatty liver disease (NAFLD);
   Non-alcoholic steatohepatitis (NASH); Fatty liver; Steatohepatitis;
   Insulin resistance (IR); Lysosomal acid lipase (LAL)
ID INSULIN-RESISTANCE; METABOLIC SYNDROME; OXIDATIVE STRESS; GUT
   MICROBIOME; POSITION PAPER; NAFLD; NASH; ASSOCIATION; ADIPOKINES;
   PROGRESSION
AB Non-alcoholic fatty liver disease (NAFLD), characterized by the accumulation of excessive intrahepatic fat, is a leading metabolic disorder also considered as the hepatic manifestation of metabolic syndrome (MS). Though more commonly observed in obese individuals and those with metabolic risk factors, it also develops in a considerable number of non-obese individuals as well as participants without having any component of MS. The basic mechanism involved in the development of fatty liver is the imbalance between lipid uptake, synthesis, and metabolism in the liver, normally controlled by several mechanisms to maintain lipid homeostasis. As a complex progressive liver disorder, the NAFLD pathogenesis is multifactorial, and several new pathogenic phenomena were discovered over time. The available liter-ature suggests the role of both genetic and environmental factors and associated metabolic factors; however, the mechanism of progression is not completely understood. In this review, we discuss different pathogenic mechanisms and their interplay to provide an elaborate idea regarding NAFLD development and progression. Better understanding of pathogenic mechanisms will be useful in finding new treatment for patients with NAFLD.& COPY; 2022 The Third Affiliated Hospital of Sun Yat-sen University. Publishing services by Elsevier B. V. on behalf of KeAi Communications Co., Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
C1 [Bashir, Aamir; Tiwari, Pramil] Natl Inst Pharmaceut Educ & Res, Dept Pharm Practice, Mohali, Punjab, India.
   [Duseja, Ajay; De, Arka; Mehta, Manu] Post Grad Inst Med Educ & Res, Dept Hepatol, Chandigarh, India.
C3 National Institute of Pharmaceutical Education & Research, S.A.S. Nagar
   (Mohali); Post Graduate Institute of Medical Education & Research
   (PGIMER), Chandigarh
RP Tiwari, P (corresponding author), Natl Inst Pharmaceut Educ & Res, Dept Pharm Practice, Mohali, Punjab, India.
EM ptiwari@niper.ac.in
RI ; De, Arka/AAK-7972-2021
OI Tiwari, Pramil/0000-0003-0442-7880; De, Arka/0000-0002-8567-1676
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NR 130
TC 18
Z9 18
U1 1
U2 9
PU KEAI PUBLISHING LTD
PI BEIJING
PA 16 DONGHUANGCHENGGEN NORTH ST, Building 5, Room 411, BEIJING, DONGCHENG
   DISTRICT 100009, PEOPLES R CHINA
SN 2096-2878
EI 2542-5684
J9 LIVER RES-PRC
JI Liver Res.
PD JUN
PY 2022
VL 6
IS 2
BP 72
EP 83
DI 10.1016/j.livres.2022.05.002
PG 12
WC Gastroenterology & Hepatology
WE Emerging Sources Citation Index (ESCI)
SC Gastroenterology & Hepatology
GA Q2LU7
UT WOS:001055891100001
PM 39958625
OA gold
DA 2025-06-11
ER

PT J
AU Del Rio, R
   Quintanilla, RA
   Orellana, JA
   Retamal, MA
AF Del Rio, Rodrigo
   Quintanilla, Rodrigo A.
   Orellana, Juan A.
   Retamal, Mauricio A.
TI Neuron-Glia Crosstalk in the Autonomic Nervous System and Its Possible
   Role in the Progression of Metabolic Syndrome: A New Hypothesis
SO FRONTIERS IN PHYSIOLOGY
LA English
DT Article
DE glia; connexins; metabolic syndrome; mitochondria; tripartite synapse;
   hemichannels
ID ACTIVATED PROTEIN-KINASE; GAP-JUNCTION HEMICHANNELS; PRO-INFLAMMATORY
   CYTOKINES; NITRIC-OXIDE SYNTHASE; GLUTAMATE RELEASE; ATP RELEASE;
   OXIDATIVE STRESS; PANNEXIN 1; MITOCHONDRIAL DYSFUNCTION; CONNEXIN-43
   HEMICHANNELS
AB Metabolic syndrome (MS) is characterized by the following physiological alterations: increase in abdominal fat, insulin resistance, high concentration of triglycerides, low levels of HDL, high blood pressure, and a generalized inflammatory state. One of the pathophysiological hallmarks of this syndrome is the presence of neurohumoral activation, which involve autonomic imbalance associated to hyperactivation of the sympathetic nervous system. Indeed, enhanced sympathetic drive has been linked to the development of endothelial dysfunction, hypertension, stroke, myocardial infarct, and obstructive sleep apnea. Glial cells, the most abundant cells in the central nervous system, control synaptic transmission, and regulate neuronal function by releasing bioactive molecules called gliotransmitters. Recently, a new family of plasma membrane channels called hemichannels has been described to allow the release of gliotransmitters and modulate neuronal firing rate. Moreover, a growing amount of evidence indicates that uncontrolled hemichannel opening could impair glial cell functions, affecting synaptic transmission and neuronal survival. Given that glial cell functions are disturbed in various metabolic diseases, we hypothesize that progression of MS may relies on hemichannel-dependent impairment of glial-to-neuron communication by a mechanism related to dysfunction of inflammatory response and mitochondrial metabolism of glial cells. In this manuscript, we discuss how glial cells may contribute to the enhanced sympathetic drive observed in MS, and shed light about the possible role of hemichannels in this process.
C1 [Del Rio, Rodrigo; Quintanilla, Rodrigo A.] Univ Autonoma Chile, Ctr Invest Biomed, Santiago, Chile.
   [Del Rio, Rodrigo] Univ Cient Sur, Direcc Invest, Lima, Peru.
   [Orellana, Juan A.] Pontificia Univ Catolica Chile, Escuela Med, Dept Neurol, Santiago, Chile.
   [Retamal, Mauricio A.] Univ Desarrollo, Clin Alemana, Fac Med, Ctr Fisiol Celular & Integrat, Santiago, Chile.
C3 Universidad Autonoma de Chile; Universidad Cientifica del Sur
   (CIENTIFICA); Pontificia Universidad Catolica de Chile; Clinica Alemana;
   Universidad del Desarrollo
RP Quintanilla, RA (corresponding author), Univ Autonoma Chile, Ctr Invest Biomed, Santiago, Chile.
EM rodrigo.quintanilla@uautonoma.cl; mretamal@udd.cl
RI Retamal, Mauricio/AAS-3621-2020; QUINTANILLA, RODRIGO/ABG-8829-2021;
   Orellana, Juan/F-6148-2012; Del Rio, Rodrigo/AAF-8763-2020
OI Orellana, Juan Andres/0000-0003-4076-207X; Retamal, Mauricio
   A./0000-0003-2562-6686; Quintanilla, Rodrigo/0000-0002-9582-6379
FU FONDECYT [1140275, 1140968, 11121133, 1120214]; International Society
   for Neurochemistry; Comision Nacional de investigacion Cientifica y
   Tecnologica [ACT 1104, ACT 1411]
FX This work was financed by FONDECYT 1140275 (to RDR), 1140968 (to RAQ),
   11121133 (to JAO) and 1120214 (to MAR). The Committee for Aid and
   Education in Neurochemistry from the International Society for
   Neurochemistry (to JAO), and Comision Nacional de investigacion
   Cientifica y Tecnologica ACT 1104 (to MAR) and ACT 1411 (to RQ and JAO).
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NR 180
TC 12
Z9 13
U1 0
U2 0
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-042X
J9 FRONT PHYSIOL
JI Front. Physiol.
PD DEC 1
PY 2015
VL 6
AR 350
DI 10.3389/fphys.2015.00350
PG 13
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA VF7RT
UT WOS:000443545400001
PM 26648871
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Kajioka, T
   Miura, K
   Kitahara, Y
   Yamagishi, S
AF Kajioka, T.
   Miura, K.
   Kitahara, Y.
   Yamagishi, S.
TI Potential utility of combination therapy with nateglinide and
   telmisartan for metabolic derangements in Zucker Fatty rats
SO HORMONE AND METABOLIC RESEARCH
LA English
DT Article
DE insulin resistance; metabolic syndrome; postprandial hyperglycemia;
   telmisartan
ID OXIDATIVE STRESS; COMPLICATIONS; HYPERGLYCEMIA
AB The metabolic syndrome is strongly associated with insulin resistance and has been recognized as a cluster of risk factors for cardiovascular disease. Insulin resistance and/or impaired early-phase insulin secretion are major determinants of postprandial hyperglycemia. In this study, we investigated the potential utility of combination therapy with telmisartan, an angiotensin 11 receptor blocker and nateglinide, a rapid-onset/short-duration insulinotropic agent, for the treatment of postprandial hyperglycemia and metabolic derangements in Zucker Fatty (ZF) rats. ZF rats fed twice daily were given vehicle, 50 mg/kg of nateglinide, 5 mg/kg of telmisartan, or both for 6 weeks. Combination therapy with nateglinide and telmisartan for 2 weeks ameliorated postprandial hyperglycemia in ZF rats fed twice daily. Further-more, 6-week treatment with nateglinide and telmisartan not only decreased fasting plasma insulin, triglycerides, and free fatty acid levels, but also improved the responses of blood glucose to insulin and subsequently reduced the decremental glucose areas under the curve in the ZF rats. Combination therapy also restored the decrease of plasma adiponectin levels in the ZF rats. Monotherapy with nateglinide or telmisartan alone did not significantly improve these metabolic parameters. These observations demonstrate that combination therapy with nateglinide and telmisartan may improve the metabolic derangements by ameliorating early phase of insulin secretion as well as insulin resistance in ZF rats fed twice daily. Our present findings suggest that the combination therapy with nateglinide and telmisartan could be a promising therapeutic strategy for the treatment of the metabolic syndrome.
C1 [Yamagishi, S.] Kurume Univ, Sch Med, Div Cardiovasc Med, Dept Med, Kurume, Fukuoka 8300011, Japan.
   [Kajioka, T.; Miura, K.; Kitahara, Y.] Pharmaceut Res Labs, Kawasaki, Kanagawa, Japan.
C3 Kurume University
RP Yamagishi, S (corresponding author), Kurume Univ, Sch Med, Div Cardiovasc Med, Dept Med, 67 Asahi Machi, Kurume, Fukuoka 8300011, Japan.
EM shoichi@med.kurume-u.ac.jp
OI KAJIOKA, TOSHIFUMI/0009-0004-3520-852X
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NR 17
TC 7
Z9 7
U1 0
U2 0
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0018-5043
EI 1439-4286
J9 HORM METAB RES
JI Horm. Metab. Res.
PD DEC
PY 2007
VL 39
IS 12
BP 889
EP 893
DI 10.1055/s-2007-992798
PG 5
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 251GL
UT WOS:000252360500008
PM 17987547
DA 2025-06-11
ER

PT J
AU Bellien, J
   Bozec, E
   Bounoure, F
   Khettab, H
   Malloizel-Delaunay, J
   Skiba, M
   Iacob, M
   Donnadieu, N
   Coquard, A
   Morio, B
   Laillet, B
   Rigaudière, JP
   Chardigny, JM
   Monteil, C
   Vendeville, C
   Mercier, A
   Cailleux, AF
   Blanchard, A
   Amar, J
   Fezeu, LK
   Pannier, B
   Bura-Rivière, A
   Boutouyrie, P
   Joannidès, R
AF Bellien, Jeremy
   Bozec, Erwan
   Bounoure, Frederic
   Khettab, Hakim
   Malloizel-Delaunay, Julie
   Skiba, Mohamed
   Iacob, Michele
   Donnadieu, Nathalie
   Coquard, Aude
   Morio, Beatrice
   Laillet, Brigitte
   Rigaudiere, Jean-Paul
   Chardigny, Jean-Michel
   Monteil, Christelle
   Vendeville, Cathy
   Mercier, Alain
   Cailleux, Anne-Francoise
   Blanchard, Anne
   Amar, Jacques
   Fezeu, Leopold K.
   Pannier, Bruno
   Bura-Riviere, Alessandra
   Boutouyrie, Pierre
   Joannides, Robinson
TI The effect of camelina oil on vascular function in essential
   hypertensive patients with metabolic syndrome: a randomized,
   placebo-controlled, double-blind study
SO AMERICAN JOURNAL OF CLINICAL NUTRITION
LA English
DT Article
DE camelina oil; alpha-linolenic acid; vascular function; essential
   hypertension; metabolic syndrome
ID ALPHA-LINOLENIC ACID; N-3 FATTY-ACIDS; ARTERIAL STIFFNESS;
   BLOOD-PRESSURE; EICOSAPENTAENOIC ACID; DOCOSAHEXAENOIC ACID; ENDOTHELIAL
   FUNCTION; RISK-FACTORS; METAANALYSIS; OMEGA-3-FATTY-ACIDS
AB Background: The effects of a dietary supplementation with the vegetable omega-3 alpha-linolenic acid (ALA) on cardiovascular homeostasis are unclear. In this context. it would be interesting to assess the effects of camelina oil.
   Objective: This study aimed to assess the cardiovascular and metabolic effects of camelina oil in hypertensive patients with metabolic syndrome.
   Methods: In a double-blind, placebo-controlled randomized study, treated essential hypertensive patients with metabolic syndrome received, during 6 mo, either cyclodextrin-complexed camelina oil containing approximate to 1.5 g ALA/d (n = 40) or an isocaloric placebo (n = 41), consisting of the same quantity of cyclodextrins and wheat starch. Anthropometric data, plasma lipids. glycemia, insulinemia. creatininemia. TBARs, high-sensitivity C-reactive protein, and n-3, n-6, and n-9 fatty acids in erythrocyte membranes were measured. Peripheral and central blood pressures, arterial stiffness, carotid intima-media thickness, and brachial artery endothelium-dependent flow-mediated dilatation (FMD) and endothelium-independent dilatation were assessed.
   Results: Compared with placebo. camelina oil increased ALA (mean +/- SD: 0 +/- 0.04 compared with 0.08 +/- 0.06%. P <0.001), its elongation product EPA (0 +/- 0.5 compared with 0.16 +/- 0.65%, P <0.05), and the n-9 gondoic acid (GA; 0 f 0.04 compared with 0.08 +/- 0.04%, P <0.001). No between-group difference was observed for cardiovascular parameters. Ilowever, changes in FMD were associated with the magnitude of changes in EPA (r = 0.26, P = 0.03). Compared with placebo. camelina oil increased fasting glycemia (-0.2 +/- 0.6 compared with 0.3 +/- 0.5 mmol/L. P <0.001) and HOMA-IR index (-0.8 +/- 25 compared with 0.5 +/- 0.9. P <0.01). without affecting plasma lipids, or inflammatory and oxidative stress markers. Changes in HOMA-IR index were correlated with the magnitude of changes in GA (r = 0.32, P <0.01). Nutritional intake remained similar between groups.
   Conclusion: ALA supplementation with camelina oil did not improve vascular function but adversely affected glucose metabolism in hypertensive patients with metabolic syndrome. Whether this adverse effect on insulin sensitivity is related to GA enrichment, remains to be elucidated.
C1 [Bellien, Jeremy; Iacob, Michele; Joannides, Robinson] Rouen Univ Hosp, Dept Pharmacol, Rouen, France.
   [Bellien, Jeremy; Iacob, Michele; Joannides, Robinson] Normandie Univ, Rouen Normandy Univ UNIROUEN, Inst Natl Santa & Rech Med INSERM, Federat Hosp Univ CArdiac Res Network Aort VAlve, Rouen, France.
   [Bellien, Jeremy; Cailleux, Anne-Francoise; Joannides, Robinson] Rouen Univ Hosp, Ctr Invest Clin CIC INSERM 1404, Rouen, France.
   [Bozec, Erwan; Khettab, Hakim; Boutouyrie, Pierre] Univ Paris, Serv Pharmacol, INSERM U970, Equipe 7, Paris, France.
   [Bozec, Erwan] Univ Lorraine, Ctr Invest Clin Plurithemat, Nancy, France.
   [Bozec, Erwan] CHRU Nancy, INSERM 1433, Nancy, France.
   [Bozec, Erwan] Inserm DCAC, Nancy, France.
   [Bozec, Erwan] F CRIN INI CRCT Cardiovasc & Renal Clin Trialists, Nancy, France.
   [Bounoure, Frederic] Normandie Univ, UNIROUEN, Pharm Galen, INSERM U1239, Rouen, France.
   [Khettab, Hakim; Skiba, Mohamed; Boutouyrie, Pierre] HEGP, AP HP, Serv Pharmacol, Paris, France.
   [Malloizel-Delaunay, Julie; Bura-Riviere, Alessandra] Univ Hosp Toulouse, Dept Vasc Med, Toulouse, France.
   [Donnadieu, Nathalie; Coquard, Aude] Rouen Univ Hosp, Dept Pharm, Rouen, France.
   [Morio, Beatrice; Laillet, Brigitte; Rigaudiere, Jean-Paul; Chardigny, Jean-Michel] Univ Clermont Auvergne, Inst Natl Rech Agr Alimentat & Environm INRAE, Unite Nutr Humaine UNH, CRNH Auvergne, Clermont Ferrand, France.
   [Monteil, Christelle; Vendeville, Cathy] Normandie Univ, ABTE, UNICAEN, UNIROUEN, Rouen, France.
   [Mercier, Alain] Univ Paris 13, SMBH, Dept Gen Practice, Bobigny, France.
   [Blanchard, Anne] Hop Europeen Georges Pompidou, AP HP, Ctr Invest Clin INSERM CIC 1418, Paris, France.
   [Amar, Jacques] Toulouse Univ III, Dept Arterial Hypertens, Toulouse, France.
   [Fezeu, Leopold K.] Univ Paris CRESS, Sorbonne Paris Nord Univ, INSERM U1153, INRAE U1125,CNAM,Nutr Epidemiol Res Team EREN,Epi, Bobigny, France.
   [Pannier, Bruno] Ctr Hosp FH Manhes, Dept Nephrol, Fleury Merogis, France.
C3 Universite de Rouen Normandie; CHU de Rouen; Universite de Rouen
   Normandie; Universite de Rouen Normandie; CHU de Rouen; Universite Paris
   Cite; Institut National de la Sante et de la Recherche Medicale
   (Inserm); Institut National de la Sante et de la Recherche Medicale
   (Inserm); Universite de Lorraine; CHU de Nancy; Institut National de la
   Sante et de la Recherche Medicale (Inserm); Institut National de la
   Sante et de la Recherche Medicale (Inserm); Universite de Rouen
   Normandie; Institut National de la Sante et de la Recherche Medicale
   (Inserm); Assistance Publique Hopitaux Paris (APHP); Universite Paris
   Cite; Hopital Universitaire Europeen Georges-Pompidou - APHP; CHU de
   Toulouse; Universite de Toulouse; Universite Toulouse III - Paul
   Sabatier; Universite de Rouen Normandie; CHU de Rouen; INRAE; Universite
   Clermont Auvergne (UCA); Universite de Rouen Normandie; Universite de
   Caen Normandie; Universite Paris 13; Assistance Publique Hopitaux Paris
   (APHP); Universite Paris Cite; Hopital Universitaire Europeen
   Georges-Pompidou - APHP; Institut National de la Sante et de la
   Recherche Medicale (Inserm); Universite Paris Cite; heSam Universite;
   Conservatoire National Arts & Metiers (CNAM); INRAE
RP Bellien, J (corresponding author), Rouen Univ Hosp, Dept Pharmacol, Rouen, France.; Bellien, J (corresponding author), Normandie Univ, Rouen Normandy Univ UNIROUEN, Inst Natl Santa & Rech Med INSERM, Federat Hosp Univ CArdiac Res Network Aort VAlve, Rouen, France.; Bellien, J (corresponding author), Rouen Univ Hosp, Ctr Invest Clin CIC INSERM 1404, Rouen, France.
EM jeremy.bellien@chu-rouen.fr
RI Monteil, Christelle/ABF-3312-2022; khettab, hakim/AAQ-5819-2021;
   boutouyrie, pierre/HGT-8201-2022; Morio, Béatrice/JCD-6492-2023;
   Boutouyrie, Pierre/J-8592-2015; Morio, Beatrice/G-3571-2018
OI Boutouyrie, Pierre/0000-0002-4375-3569; Lab, Carmen/0000-0002-5935-3236;
   Morio, Beatrice/0000-0002-2418-1438; Monteil,
   Christelle/0000-0002-4981-0800; Jeremy, Bellien/0000-0002-0383-2342;
   khettab, hakim/0000-0001-8351-3845
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NR 52
TC 4
Z9 5
U1 0
U2 4
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0002-9165
EI 1938-3207
J9 AM J CLIN NUTR
JI Am. J. Clin. Nutr.
PD MAR 4
PY 2022
VL 115
IS 3
BP 694
EP 704
DI 10.1093/ajcn/nqab374
EA JAN 2022
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA ZM3LU
UT WOS:000764264200012
PM 34791007
OA Green Submitted, Bronze
DA 2025-06-11
ER

PT J
AU Varalda, M
   Venetucci, J
   Nikaj, H
   Kankara, CR
   Garro, G
   Keivan, N
   Bettio, V
   Marzullo, P
   Antona, A
   Valente, G
   Gentilli, S
   Capello, D
AF Varalda, Marco
   Venetucci, Jacopo
   Nikaj, Herald
   Kankara, Chaitanya Reddy
   Garro, Giulia
   Keivan, Nazanin
   Bettio, Valentina
   Marzullo, Paolo
   Antona, Annamaria
   Valente, Guido
   Gentilli, Sergio
   Capello, Daniela
TI Second-Generation Antipsychotics Induce Metabolic Disruption in Adipose
   Tissue-Derived Mesenchymal Stem Cells Through an aPKC-Dependent Pathway
SO CELLS
LA English
DT Article
DE second-generation antipsychotics; insulin resistance; adipose tissue;
   adipose-derived mesenchymal stem cells; insulin signaling; endocytosis;
   lysosomes; PKC zeta
ID PROTEIN-KINASE-C; INSULIN-RECEPTOR SUBSTRATE-1; PHOSPHATIDIC-ACID;
   PHOSPHOLIPASE-D; IN-VITRO; OBESITY; PHOSPHORYLATION; ENDOCYTOSIS;
   AUTOPHAGY; ZETA
AB Metabolic syndrome (MetS) is a cluster of metabolic abnormalities, including visceral obesity, dyslipidemia, and insulin resistance. In this regard, visceral white adipose tissue (vWAT) plays a critical role, influencing energy metabolism, immunomodulation, and oxidative stress. Adipose-derived stem cells (ADSCs) are key players in these processes within vWAT. While second-generation antipsychotics (SGAs) have significantly improved treatments for mental health disorders, their chronic use is associated with an increased risk of MetS. In this study, we explored the impact of SGAs on ADSCs to better understand their role in MetS and identify potential therapeutic targets. Our findings reveal that olanzapine disrupts lipid droplet formation during adipogenic differentiation, impairing insulin receptor endocytosis, turnover, and signaling. SGAs also alter the endolysosomal compartment, leading to acidic vesicle accumulation and increased lysosomal biogenesis through TFEB activation. PKC zeta is crucial for the SGA-induced nuclear translocation of TFEB and acidic vesicle formation. Notably, inhibiting PKC zeta restored insulin receptor tyrosine phosphorylation, normalized receptor turnover, and improved downstream signaling following olanzapine treatment. This activation of PKC zeta by olanzapine is driven by increased phosphatidic acid synthesis via phospholipase D (PLD), following G protein-coupled receptor (GPCR) signaling activation. Overall, olanzapine and clozapine disrupt endolysosomal homeostasis and insulin signaling in a PKC zeta-dependent manner. These findings highlight SGAs as valuable tools for uncovering cellular dysfunction in vWAT during MetS and may guide the development of new therapeutic strategies to mitigate the metabolic side effects of these drugs.
C1 [Varalda, Marco; Venetucci, Jacopo; Kankara, Chaitanya Reddy; Garro, Giulia; Keivan, Nazanin; Bettio, Valentina; Marzullo, Paolo; Antona, Annamaria; Valente, Guido; Gentilli, Sergio; Capello, Daniela] Univ Piemonte Orientale, Ctr Excellence Aging Sci, Dept Translat Med, I-28100 Novara, Italy.
   [Varalda, Marco; Venetucci, Jacopo; Garro, Giulia; Bettio, Valentina; Capello, Daniela] Univ Piemonte Orientale, UPO Biobank, I-28100 Novara, Italy.
   [Nikaj, Herald; Gentilli, Sergio] Univ Piemonte Orientale, Gen Surg Div, AOU Maggiore Car, I-28100 Novara, Italy.
   [Valente, Guido] Osped St Andrea, Pathol Unity, I-13100 Vercelli, Italy.
   [Gentilli, Sergio] Univ Piemonte Orientale, Dept Hlth Sci, I-28100 Novara, Italy.
C3 University of Eastern Piedmont Amedeo Avogadro; University of Eastern
   Piedmont Amedeo Avogadro; University of Eastern Piedmont Amedeo
   Avogadro; University of Eastern Piedmont Amedeo Avogadro
RP Varalda, M (corresponding author), Univ Piemonte Orientale, Ctr Excellence Aging Sci, Dept Translat Med, I-28100 Novara, Italy.; Varalda, M (corresponding author), Univ Piemonte Orientale, UPO Biobank, I-28100 Novara, Italy.
EM marco.varalda@uniupo.it; jacopo.venetucci@uniupo.it;
   20027483@studenti.uniupo.it; 20041555@studenti.uniupo.it;
   giulia.garro@uniupo.it; 20047723@studenti.uniupo.it;
   valentina.bettio@med.uniupo.it; paolo.marzullo@med.uniupo.it;
   annamaria.antona@uniupo.it; guido.valente@med.uniupo.it;
   sergio.gentilli@med.uniupo.it; daniela.capello@med.uniupo.it
RI Bettio, Valentina/AFT-9834-2022; Antona, Annamaria/ISS-2899-2023;
   Marzullo, Paolo/K-6371-2016; Capello, Daniela/J-4110-2012
OI Varalda, Marco/0009-0001-8319-2057; Marzullo, Paolo/0000-0003-3215-5747;
   Venetucci, Jacopo/0009-0006-0191-1959; KANKARA, CHAITANYA
   REDDY/0009-0001-9820-8250; Capello, Daniela/0000-0001-9157-8753; Garro,
   Giulia/0009-0002-2611-5327
FU MUR-M4C2 1.3 of PNRR [MUR-M4C2 1.3, PE0000015]; Italian Ministry of
   University and Research (MUR) program [2023-2027, P2022E3BTH-CUP
   C53D23007600001]
FX This research was funded by the project AGE-IT, which received funding
   from the MUR-M4C2 1.3 of PNRR under grant agreement no. PE0000015. This
   study was (partially) funded by the Italian Ministry of University and
   Research (MUR) program, "Departments of Excellence 2023-2027", the AGING
   Project-Department of Translational Medicine, University of Piemonte
   Orientale, and is part of the project, P2022E3BTH-CUP C53D23007600001,
   which received funding from NextGeneration EU-MUR M4C2-PRIN 2022 PNRR.
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NR 144
TC 0
Z9 0
U1 0
U2 0
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2073-4409
J9 CELLS-BASEL
JI Cells
PD DEC
PY 2024
VL 13
IS 24
AR 2084
DI 10.3390/cells13242084
PG 30
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA Q3P8F
UT WOS:001383852700001
PM 39768174
OA gold
DA 2025-06-11
ER

PT J
AU Solís, CB
   Fantin, R
   Kelly-Irving, M
   Delpierre, C
AF Solis, Cristina Barboza
   Fantin, Romain
   Kelly-Irving, Michelle
   Delpierre, Cyrille
TI Physiological wear-and-tear and later subjective health in mid-life:
   Findings from the 1958 British birth cohort
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE Allostatic load; Subjective health; Embodiment; Biomarkers; Social
   gradient; Birth cohort
ID QUALITY-OF-LIFE; BODY-MASS INDEX; ALLOSTATIC LOAD; SOCIOECONOMIC
   POSITION; METABOLIC SYNDROME; BIOLOGICAL RISK; MORTALITY; PREDICTOR;
   MACARTHUR; OBESITY
AB Objective: Our body adapts continuously to environmental challenges and stressful conditions. Allostatic load (AL) is a concept that aims to capture the overall physiological wear-and-tear of the body triggered by the repeated activation of compensatory physiological mechanisms as a response to chronic stress. Growing evidence has shown a link between AL and later health decline, morbidity and mortality. However, due to the global physiological effect captured by the AL concept, it is particularly pertinent to examine its association with subsequent health by taking a broad definition of the latter. We examined the association between AL at 44 years and general health as measured by a latent multidimensional measure of subjective health at 50 years integrating sleep patterns, physical and mental health.
   Methods: AL was constructed using 14 biomarkers representing four physiological systems on 7573 members of the 1958 British birth cohort. Health status was captured using self-reported information about subjective health and summarized using a principal component analysis including: seven dimensions of the SF-36 questionnaire of health-related quality of life, the sleep subscale of the Medical Outcomes Study characterizing quality of sleep patterns, and a malaise inventory score detecting depressive symptoms.
   Results: Higher AL score was gradually associated with worse subjective health, after taking into account classic confounders.
   Conclusions: Using a physiological index to grasp how the environment can "get under the skin" leading to poor health is of great interest, permitting a better understanding of life course origins of disease and social gradients in health. (C) 2016 The Authors. Published by Elsevier Ltd.
C1 [Solis, Cristina Barboza; Fantin, Romain; Kelly-Irving, Michelle; Delpierre, Cyrille] Univ Toulouse III Paul Sabatier, INSERM, LEASP, UMR 1027, Toulouse, France.
   [Solis, Cristina Barboza] Univ Costa Rica, San Jose 2060, Costa Rica.
C3 Universite de Toulouse; Universite Toulouse III - Paul Sabatier;
   Institut National de la Sante et de la Recherche Medicale (Inserm);
   Universidad Costa Rica
RP Solís, CB (corresponding author), Univ Paul Sabatier, INSERM, UMR 1027, Fac Med, 37 Allees Jules Guesde, F-31000 Toulouse, France.
EM cristina.barboza-solis@inserm.fr
RI Fantin, Romain/AAJ-2500-2020; Kelly-Irving, Michelle/G-3151-2010;
   Barboza Solis, Cristina/AAB-9922-2020
OI Fantin, Romain/0000-0003-2906-3438; delpierre,
   cyrille/0000-0002-0831-080X; Kelly-Irving, Michelle/0000-0001-5749-4791;
   Barboza Solis, Cristina/0000-0002-7208-7374
FU ESRC [ES/M001660/1] Funding Source: UKRI
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NR 62
TC 28
Z9 32
U1 0
U2 11
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD DEC
PY 2016
VL 74
BP 24
EP 33
DI 10.1016/j.psyneuen.2016.08.018
PG 10
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA EB6VW
UT WOS:000387524700004
PM 27567118
OA hybrid
DA 2025-06-11
ER

PT J
AU Froogh, G
   Kandhi, S
   Duvvi, R
   Le, YC
   Weng, Z
   Alruwaili, N
   Ashe, JO
   Sun, D
   Huang, A
AF Froogh, Ghezal
   Kandhi, Sharath
   Duvvi, Roopa
   Le, Yicong
   Weng, Zan
   Alruwaili, Norah
   Ashe, Jonathan O.
   Sun, Dong
   Huang, An
TI The contribution of chymase-dependent formation of ANG II to cardiac
   dysfunction in metabolic syndrome of young rats: roles of fructose and
   EETs
SO AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
LA English
DT Article
DE angiotensin II; chymase; high fructose; metabolic syndrome; soluble
   epoxide hydrolase
ID SOLUBLE EPOXIDE HYDROLASE; ANGIOTENSIN-CONVERTING ENZYME-2; DIETARY
   FRUCTOSE; NADPH OXIDASE; INHIBITION; MEDIATORS; PREVENTS; SYSTEM;
   MUSCLE; ACID
AB The roles of ACE-independent ANG II production via chymase and therapeutic potential of epoxyeicosatrienoic acids (EETs) in fructose-induced metabolic syndrome (MetS) in the adolescent population remain elusive. Thus we tested the hypothesis that a high-fructose diet (HFD) in young rats elicits chymase-dependent increases in ANG II production and oxidative stress, responses that are reversible by 1-trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl) urea (TPPU), an inhibitor of soluble epoxide hydrolase (sEH) that metabolizes EETs. Three groups of weanling rats (21-day-old) were fed a normal diet, 60% HFD, and HFD with TPPU, respectively, for 30 days. HFD rats developed MetS, characterized by hyperglycemia, hyperinsulinemia, and hypertension and associated with decreases in cardiac output and stroke volume and loss of nitric oxide (NO) modulation of myocardial oxygen consumption; all impairments were normalized by TPPU that significantly elevated circulating 11,12-EET, a major cardiac EET isoform. In the presence of comparable cardiac angiotensin-converting enzyme (ACE) expression/activity among the three groups, HFD rats exhibited significantly greater chymase-dependent ANG II formation in hearts, as indicated by an augmented cardiac chymase content as a function of enhanced mast cell degranulation. The enhanced chymase-dependent ANG II production was paralleled with increases in ANG II type 1 receptor (AT1R) expression and NADPH oxidase (Nox)-induced superoxide, alterations that were significantly reversed by TPPU. Conversely, HFD-induced downregulation of cardiac ACE2, followed by a lower Ang-(1-7) level displayed in an TPPU-irreversible manner. In conclusion, HFD-driven adverse chymase/ANG II/Nox/superoxide signaling in young rats was prevented by inhibition of sEH via, at least in part, an EET-mediated stabilization of mast cells, highlighting chymase and sEH as therapeutic targets during treatment of MetS.
   NEW & NOTEWORTHY As the highest fructose consumers, the adolescent population is highly susceptible to the metabolic syndrome, where increases in mast cell chymase-dependent formation of ANG II, ensued by cardiometabolic dysfunction, are reversible in response to inhibition of soluble epoxide hydrolase (sEH). This study highlights chymase and sEH as therapeutic targets and unravels novel avenues for the development of optimal strategies for young patients with fructose-induced metabolic syndrome.
C1 [Froogh, Ghezal; Kandhi, Sharath; Duvvi, Roopa; Le, Yicong; Weng, Zan; Alruwaili, Norah; Ashe, Jonathan O.; Sun, Dong; Huang, An] New York Med Coll, Dept Physiol, Valhalla, NY 10595 USA.
C3 New York Medical College
RP Huang, A (corresponding author), New York Med Coll, Dept Physiol, Valhalla, NY 10595 USA.
EM an_huang@nymc.edu
RI Le, Yi/JUF-6980-2023
FU National Heart, Lung, and Blood Institute [HL-070653, HL-129797,
   HL-144528]
FX This work was supported by National Heart, Lung, and Blood Institute
   Grants HL-070653, HL-129797, and HL-144528.
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NR 49
TC 12
Z9 12
U1 0
U2 0
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0363-6135
EI 1522-1539
J9 AM J PHYSIOL-HEART C
JI Am. J. Physiol.-Heart Circul. Physiol.
PD APR
PY 2020
VL 318
IS 4
BP H985
EP H993
DI 10.1152/ajpheart.00633.2019
PG 9
WC Cardiac & Cardiovascular Systems; Physiology; Peripheral Vascular
   Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Physiology
GA LC4VH
UT WOS:000525323400015
PM 32167781
OA Green Published
DA 2025-06-11
ER

PT J
AU Vara-García, C
   Romero-Moreno, R
   Barrera-Caballero, S
   Pedroso-Chaparro, MD
   Jiménez-Gonzalo, L
   Olazarán, J
   Mausbach, B
   von Känel, R
   Losada-Baltar, A
AF Vara-Garcia, Carlos
   Romero-Moreno, Rosa
   Barrera-Caballero, Samara
   Pedroso-Chaparro, Maria del Sequeros
   Jimenez-Gonzalo, Lucia
   Olazaran, Javier
   Mausbach, Brent
   von Kanel, Roland
   Losada-Baltar, Andres
TI Associations Between Dysfunctional Thoughts, Leisure Activities, and
   IL-6 in Caregivers of Family Members With Dementia
SO PSYCHOSOMATIC MEDICINE
LA English
DT Article
DE caregivers; dementia; dysfunctional thoughts; inflammation; leisure; BMI
   = body mass index; BPSD = behavioral and psychological symptoms of
   dementia; HDL = high-density lipoprotein; IL-6=interleukin 6
ID CORONARY-HEART-DISEASE; CONFIRMATORY FACTOR-ANALYSIS; INSOMNIA SEVERITY
   INDEX; DEPRESSIVE SYMPTOMS; CHRONIC STRESS; ALZHEIMERS-DISEASE; PHYSICAL
   HEALTH; BLOOD-PRESSURE; INFLAMMATORY CYTOKINES; METABOLIC SYNDROME
AB ObjectiveDementia caregiving is associated with negative physical health consequences, including inflammation processes. The objective of this study was to analyze the associations between dysfunctional thoughts, frequency of leisure activities, and interleukin 6 (IL-6) in a sample of dementia family caregivers.MethodsOne hundred forty dementia caregivers participated in this cross-sectional study. The relationships among caregivers' dysfunctional thoughts, leisure activities, and IL-6 were adjusted for demographic characteristics, stressors, and physical and mental health indicators in a linear regression analysis.ResultsHigher levels of dysfunctional thoughts (t = -2.02, p = .045) were significantly associated with lower frequency of leisure activities. In turn, lower frequency of leisure activities was significantly associated with higher levels of IL-6 (t = -2.03, p = .045). Dysfunctional thoughts were no longer significantly associated with IL-6 levels when both dysfunctional thoughts and leisure activities were included in the same model (t = 1.78, p = .076). A significant indirect effect was found for the association between higher levels of dysfunctional thoughts and higher levels of IL-6 (standardized indirect effect = 0.036, bootstrap standard error = 0.026, 95% confidence interval = 0.0001-0.1000) through its association with fewer leisure activities.ConclusionsOur findings suggest that the direct effect of caregivers' dysfunctional thoughts on IL-6 may be mediated by the impact on caregivers' frequency of leisure activities. Results suggest that training caregivers in reducing dysfunctional thoughts to thereby increase leisure activities may be useful in reducing inflammation.
C1 [Vara-Garcia, Carlos; Romero-Moreno, Rosa; Barrera-Caballero, Samara; Jimenez-Gonzalo, Lucia; Losada-Baltar, Andres] Univ Rey Juan Carlos, Dept Psychol, Alcorcon, Spain.
   [Pedroso-Chaparro, Maria del Sequeros] Univ Autonoma Madrid, Dept Biol & Hlth Psychol, Madrid, Spain.
   [Olazaran, Javier] Hosp Gen Univ Gregorio Maranon, Dept Neurol, Madrid, Spain.
   [Mausbach, Brent] Univ Calif San Diego, Dept Psychiat, San Diego, CA USA.
   [von Kanel, Roland] Univ Zurich, Univ Hosp Zurich, Dept Consultat Liaison Psychiat & Psychosomat Med, Zurich, Switzerland.
C3 Universidad Rey Juan Carlos; Autonomous University of Madrid; General
   University Gregorio Maranon Hospital; University of California System;
   University of California San Diego; University of Zurich; University
   Zurich Hospital
RP Vara-García, C (corresponding author), Univ Rey Juan Carlos, Dept Psicol, Campus Alcorcon,Ave Atenas s-n, Madrid 28822, Spain.
EM carlos.vara@urjc.es; rosa.romero@urjc.es; samara.barrera@urjc.es;
   maria.pedroso@uam.es; lucia.jimenez@urjc.es; javier@mariawolff.es;
   bmausbach@health.ucsd.edu; Roland.VonKaenel@usz.ch;
   andres.losada@urjc.es
RI del Sequeros Pedroso-Chaparro, María/ACK-9895-2022; Jiménez Gonzalo,
   Lucía/GLV-3720-2022; Losada, Andres/C-8920-2011; von Kanel,
   Roland/B-1811-2019; Vara Garcia, Carlos/S-7534-2018; Romero Moreno,
   Rosa/G-3479-2011
OI Losada, Andres/0000-0002-3134-7133; Barrera Caballero,
   Samara/0000-0002-0987-3188; von Kanel, Roland/0000-0002-8929-5129;
   Olazaran, Javier/0000-0002-7320-128X; Jimenez-Gonzalo,
   Lucia/0000-0002-2305-3362; Vara Garcia, Carlos/0000-0002-5379-5770;
   Romero Moreno, Rosa/0000-0001-5454-3586; Pedroso-Chaparro, Maria del
   Sequeros/0000-0002-5224-9137
FU Spanish Ministry of Science and Innovation [PSI2015-65152-C2-1-R,
   PDI2019-106714RB-C21]; FPU grant from the Spanish Ministry of Education;
   Universidad Autonoma de Madrid; Universidad Rey Juan Carlos; US National
   Institutes of Health;  [R01 AG061941]
FX The preparation of this article was supported in part by grants from the
   Spanish Ministry of Science and Innovation under grants
   PSI2015-65152-C2-1-R and PDI2019-106714RB-C21. S.B.-C. was supported by
   an FPU grant FPU17/02548 from the Spanish Ministry of Education.
   M.d.S.P.-C. was supported by a predoctoral grant from the Universidad
   Autonoma de Madrid. L.J.-G. was supported by a predoctoral grant from
   the Universidad Rey Juan Carlos. B.M. was supported by the US National
   Institutes of Health via grant number R01 AG061941. The authors declare
   no conflict of interest.
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NR 70
TC 1
Z9 1
U1 2
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0033-3174
EI 1534-7796
J9 PSYCHOSOM MED
JI Psychosom. Med.
PD FEB-MAR
PY 2023
VL 85
IS 2
BP 175
EP 181
DI 10.1097/PSY.0000000000001158
PG 7
WC Psychiatry; Psychology; Psychology, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry; Psychology
GA 9K9QQ
UT WOS:000941194800008
PM 36516289
DA 2025-06-11
ER

PT J
AU Joung, KE
   Park, KH
   Zaichenko, L
   Sahin-Efe, A
   Thakkar, B
   Brinkoetter, M
   Usher, N
   Warner, D
   Davis, CR
   Crowell, JA
   Mantzoros, CS
AF Joung, Kyoung Eun
   Park, Kyung-Hee
   Zaichenko, Lesya
   Sahin-Efe, Ayse
   Thakkar, Bindiya
   Brinkoetter, Mary
   Usher, Nicole
   Warner, Dorothy
   Davis, Cynthia R.
   Crowell, Judith A.
   Mantzoros, Christos S.
TI Early Life Adversity Is Associated With Elevated Levels of Circulating
   Leptin, Irisin, and Decreased Levels of Adiponectin in Midlife Adults
SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Article
ID STRESS; PLASMA; EXPRESSION; CHILDHOOD; EXERCISE; OBESITY; FNDC5; ABUSE;
   WOMEN; RISK
AB Context: Early-life adversity, defined as physical, emotional, or sexual abuse and neglect before 18 years of age, is associated with metabolic syndrome, obesity, and type 2 diabetes mellitus in adult life. However, the underlying mechanism is not fully understood, and whether adipomyokines are associated with early-life adversity independent of other factors such as body mass index, psychosocial risks, and health behaviors is not known.
   Objectives: The objective of the study was to evaluate the association between early-life adversity and circulating the levels of the adipomyokines such as leptin, adiponectin, and irisin and the inflammatory marker, C-reactive protein (CRP).
   Design/Subjects/Setting: This study was a cross-sectional study of 95 adults at a university-based research center. We collected venous blood from participants and analyzed serum for leptin, adiponectin, irisin, and CRP.
   Results: Circulating leptin, irisin, and CRP levels were significantly higher in the highest adversity tertile group compared with low and middle tertile groups (P < .001 for leptin, P = .01 for irisin, and P = .02 for CRP). Adiponectin levels were lower in the highest tertile group compared with the low and middle tertile groups (P = .03). After adjusting for demographic variables, physical activity, diet, current mental health, and body mass index, the associations between early-life adversity leptin, irisin, and did not change. However, adiponectin and CRP levels were no longer significantly related to early life adversity.
   Conclusion: Early-life adversity is directly associated with elevated circulating leptin and irisin, and indirectly associated with elevated CRP and decreased adiponectin. These findings suggest that these adipomyokines may play a role in the pathogenesis of metabolic abnormality in a population with significant early life adversity.
C1 [Joung, Kyoung Eun] Boston Childrens Hosp, Div Newborn Med, Boston, MA USA.
   [Joung, Kyoung Eun; Park, Kyung-Hee; Zaichenko, Lesya; Sahin-Efe, Ayse; Thakkar, Bindiya; Brinkoetter, Mary; Mantzoros, Christos S.] Beth Israel Deaconess Med Ctr, Div Endocrinol & Metab, Boston, MA 02215 USA.
   [Joung, Kyoung Eun; Mantzoros, Christos S.] Harvard Univ, Sch Med, Boston, MA 02215 USA.
   [Park, Kyung-Hee] Hallym Univ, Sacred Heart Hosp, Dept Family Med, Gyeonggi Do 431070, South Korea.
   [Zaichenko, Lesya; Sahin-Efe, Ayse; Thakkar, Bindiya; Brinkoetter, Mary; Mantzoros, Christos S.] Boston Vet Affairs Healthcare Syst, Div Endocrinol, Endocrinol Sect, Jamaica Plain, MA 02130 USA.
   [Sahin-Efe, Ayse; Thakkar, Bindiya; Mantzoros, Christos S.] Boston Univ, Sch Med, Boston Med Ctr, Sect Endocrinol Diabet & Nutr, Boston, MA 02118 USA.
   [Usher, Nicole; Warner, Dorothy; Davis, Cynthia R.; Crowell, Judith A.] Judge Baker Childrens Ctr, Boston, MA 02120 USA.
   [Crowell, Judith A.] SUNY Stony Brook, Dept Psychiat & Behav Sci, Stony Brook, NY 11794 USA.
C3 Harvard University; Harvard University Medical Affiliates; Boston
   Children's Hospital; Harvard University; Harvard University Medical
   Affiliates; Beth Israel Deaconess Medical Center; Harvard University;
   Harvard Medical School; Hallym University; Boston University; Boston
   Medical Center; Harvard University; Harvard University Medical
   Affiliates; Judge Baker's Children's Center; State University of New
   York (SUNY) System; Stony Brook University
RP Mantzoros, CS (corresponding author), Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Div Endocrinol & Metab, FD 876,330 Brookline Ave, Boston, MA 02215 USA.
EM cmantzor@bidmc.harvard.edu
RI Park, Kyung/AAU-7867-2020; Mantzoros, Christos/Y-2902-2019
OI Joung, Kyoung Eun/0000-0002-5942-4241; Park, Kyung
   Hee/0000-0001-9806-0076; Zaichenko, Lesya/0000-0001-8489-3886
FU National Institute of Aging Grant [RO1-AG032030]; National Institute of
   Diabetes and Digestive and Kidney Diseases Grant [81913]; Harvard
   Clinical and Translational Science Center Grant from the National Center
   for Research Resources [UL1 RR025758]
FX This study was supported by the National Institute of Aging Grant
   RO1-AG032030 and National Institute of Diabetes and Digestive and Kidney
   Diseases Grant 81913. The project was also supported by Harvard Clinical
   and Translational Science Center Grant UL1 RR025758 from the National
   Center for Research Resources.
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NR 20
TC 53
Z9 59
U1 0
U2 9
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0021-972X
EI 1945-7197
J9 J CLIN ENDOCR METAB
JI J. Clin. Endocrinol. Metab.
PD JUN
PY 2014
VL 99
IS 6
BP E1055
EP E1060
DI 10.1210/jc.2013-3669
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA AP8PI
UT WOS:000342340500017
PM 24650014
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Moran, LJ
   March, WA
   Whitrow, MJ
   Giles, LC
   Davies, MJ
   Moore, VM
AF Moran, L. J.
   March, W. A.
   Whitrow, M. J.
   Giles, L. C.
   Davies, M. J.
   Moore, V. M.
TI Sleep disturbances in a community-based sample of women with polycystic
   ovary syndrome
SO HUMAN REPRODUCTION
LA English
DT Article
DE polycystic ovary syndrome; sleep disturbances; depression; obesity
ID BODY-MASS INDEX; INSULIN-RESISTANCE; GLUCOSE-TOLERANCE;
   DIAGNOSTIC-CRITERIA; DAYTIME SLEEPINESS; METABOLIC SYNDROME;
   RISK-FACTOR; APNEA; METAANALYSIS; DEPRESSION
AB STUDY QUESTION: Is there an excess of sleep disturbances in women with polycystic ovary syndrome(PCOS) in a community-based sample?
   STUDY ANSWER: Sleep disturbances are almost twice as common in women with PCOS compared with women of similar age without PCOS, with the association slightly accounted for by body weight and, to a greater extent, by depressive symptoms.
   WHAT IS KNOWN ALREADY: There is an excess of sleep-disordered breathing in clinical samples of women with PCOS, after accounting for their profile of body weight. Poor sleep patterns increase insulin resistance and thus may exacerbate PCOS symptoms and longer-term risk of metabolic disease.
   STUDY DESIGN, SIZE, DURATION: Across-sectional study of 724 women, comprising 74% of a cohort study established retrospectively when women were around age 30 years.
   PARTICIPANTS/MATERIALS, SETTING, METHODS: Comparisons were made between 87 women with PCOS, diagnosed using the Rotterdam criteria, and 637 women without this diagnosis in Adelaide, South Australia. Differences in sleep disturbances, assessed using a modified version of the Jenkins questionnaire, were investigated using ordered logistic regression.
   MAIN RESULTS AND THE ROLE OF CHANCE: Sleep disturbances were twice as common in women with PCOS compared with those without. Specifically, PCOS was associated with increasing occurrence of difficulty falling asleep (odds ratio (OR) 1.94, 95% confidence interval (CI) 1.28-2.95); this association was attenuated but still statistically significant after accounting for BMI and depressive symptoms. Increasing occurrence of difficulty maintaining sleep (OR 1.92 95% CI 1.12-3.31) was mediated by obesity and depressive symptoms, together. Other factors did not change these findings.
   LIMITATIONS, REASONS FOR CAUTION: The cross-sectional nature of the study means that the direction of associations between PCOS and sleep disturbances is unclear, although bi-directionality for the mediators is likely based on data in the wider literature.
   WIDER IMPLICATIONS OF THE FINDINGS: Our results indicate that assessment and management of both sleep and mental health problems in women with PCOS should be undertaken. Longitudinal data would be valuable to see how poor sleep affects longer-term health profiles.
C1 [Moran, L. J.; March, W. A.; Whitrow, M. J.; Giles, L. C.; Davies, M. J.; Moore, V. M.] Univ Adelaide, Robinson Res Inst, Adelaide, SA, Australia.
   [Moran, L. J.; March, W. A.; Whitrow, M. J.; Davies, M. J.] Univ Adelaide, Sch Paediat & Reprod Hlth, Adelaide, SA, Australia.
   [Whitrow, M. J.; Giles, L. C.; Moore, V. M.] Univ Adelaide, Sch Populat Hlth, Adelaide, SA, Australia.
   [Moore, V. M.] Univ Adelaide, Fay Gale Ctr Res Gender, Adelaide, SA, Australia.
C3 Robinson Research Institute; University of Adelaide; University of
   Adelaide; University of Adelaide; University of Adelaide
RP Moran, LJ (corresponding author), Univ Adelaide, Robinson Res Inst, Adelaide, SA, Australia.
EM lisa.moran@adelaide.edu.au
RI Giles, Lynne/C-8789-2009; Whitrow, Melissa/J-4013-2012; Moran,
   Lisa/E-9850-2015; davies, michael/Y-3542-2018
OI Giles, Lynne/0000-0001-9054-9088; davies, michael/0000-0003-1526-0801;
   Moran, Lisa/0000-0001-5772-6484; Whitrow, Melissa/0009-0006-0069-0031
FU Australian National Health and Medical Research Council [465455, 627033,
   349548]; Australian Research Council [FT100101018]; South Australian
   Cardiovascular Research Development Program (SACVRDP) Fellowship
   [ACI1S374]; National Heart Foundation of Australia; South Australian
   Department of Health; South Australian Health and Medical Research
   Institute; Australian Research Council [FT100101018] Funding Source:
   Australian Research Council
FX This study was supported by Australian National Health and Medical
   Research Council (Strategic Award 465455, Public Health Training
   Fellowship 627033 to L.C.G., Career Development Award in Population
   Health 349548 to M.J.D.) and the Australian Research Council (Future
   Fellowship FT100101018 to M.J.D.). L.J.M. was supported by a South
   Australian Cardiovascular Research Development Program (SACVRDP)
   Fellowship (ACI1S374); a program collaboratively funded by the National
   Heart Foundation of Australia, the South Australian Department of Health
   and the South Australian Health and Medical Research Institute.
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NR 39
TC 70
Z9 72
U1 1
U2 10
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0268-1161
EI 1460-2350
J9 HUM REPROD
JI Hum. Reprod.
PD FEB
PY 2015
VL 30
IS 2
BP 466
EP 472
DI 10.1093/humrep/deu318
PG 7
WC Obstetrics & Gynecology; Reproductive Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology; Reproductive Biology
GA CC2AK
UT WOS:000350146600024
PM 25432918
OA Bronze
DA 2025-06-11
ER

PT J
AU Stuebe, A
AF Stuebe, Alison
TI Associations Among Lactation, Maternal Carbohydrate Metabolism, and
   Cardiovascular Health
SO CLINICAL OBSTETRICS AND GYNECOLOGY
LA English
DT Article
DE lactation; hypertension; diabetes; metabolic syndrome; myocardial
   infarction
ID BODY-MASS INDEX; FEEDING INTERVENTION TRIAL; LONG-TERM DECREASE;
   BLOOD-PRESSURE; PSYCHOSOCIAL STRESS; DIABETES-MELLITUS;
   LIPID-METABOLISM; RISK-FACTORS; OBESE WOMEN; WEIGHT-LOSS
AB In mammalian reproductive physiology, lactation follows pregnancy; growing evidence suggests that disruption of this physiology affects a woman's lifetime risk of metabolic disease. These differences may reflect lactation-induced mobilization of fat stores and modulation of maternal stress reactivity. In addition, confounders may play a role: women who breastfeed for long durations are more likely to engage in other healthy behaviors, and obesity and insulin resistance may interfere with breastfeeding physiology. These findings underscore the importance of evidenced-based care to enable women to achieve their infant feeding goals.
C1 [Stuebe, Alison] Univ N Carolina, Sch Med, Maternal Fetal Med, Chapel Hill, NC 27599 USA.
   [Stuebe, Alison] Gillings Sch Global Publ Hlth, Carolina Global Breastfeeding Inst, Maternal & Child Hlth, Chapel Hill, NC USA.
C3 University of North Carolina School of Medicine; University of North
   Carolina; University of North Carolina Chapel Hill
RP Stuebe, A (corresponding author), Univ N Carolina, Sch Med, Maternal Fetal Med, 3010 Old Clin Bldg,CB 7516, Chapel Hill, NC 27599 USA.
EM astuebe@med.unc.edu
FU Lactation Effects on Postnatal Endothelial Function and Vascular
   Inflammation [R01HL109216-01A1]
FX Supported in part by R01HL109216-01A1, Lactation Effects on Postnatal
   Endothelial Function and Vascular Inflammation. The content is solely
   the responsibility of the author and does not necessarily represent the
   official views of the National Institutes of Health.
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NR 83
TC 33
Z9 36
U1 0
U2 28
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0009-9201
EI 1532-5520
J9 CLIN OBSTET GYNECOL
JI Clin. Obstet. Gynecol.
PD DEC
PY 2015
VL 58
IS 4
BP 827
EP 839
DI 10.1097/GRF.0000000000000155
PG 13
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA CV3KO
UT WOS:000364158300012
PM 26457850
OA Green Accepted, Green Submitted
DA 2025-06-11
ER

PT J
AU Lindley, KJ
   Barker, C
   Mahmoud, Z
   Raghuraman, N
   Lenzen, P
   Meyers, R
   Osmundson, S
   Huang, S
   Shah, RV
   Davila-Roman, VG
AF Lindley, Kathryn J.
   Barker, Claire
   Mahmoud, Zainab
   Raghuraman, Nandini
   Lenzen, Patricia
   Meyers, Rachel
   Osmundson, Sarah
   Huang, Shi
   Shah, Ravi V.
   Davila-Roman, Victor G.
TI Decreased postpartum exercise capacity after a diagnosis of
   pre-eclampsia: Implications for CVD risk prediction
SO AMERICAN HEART JOURNAL
LA English
DT Article
ID VENTRICULAR DIASTOLIC FUNCTION; RECOMMENDATIONS; PREGNANCY; DISEASE
AB Background Hypertensive disorders of pregnancy (HDP) are associated with increased long-term risk for cardiometabolic risk factors (chronic hypertension [HTN], obesity, diabetes) and heart failure. Exercise capacity is a known predictor of heart failure in patients with normal resting cardiac filling pressures. In this prospective observational cohort study, we sought to identify predictors of reduced postpartum exercise capacity in participants with normotensive vs preeclamptic pregnancies. Methods Preeclampsia (PreE) and normotensive subjects were enrolled to undergo bedside echocardiography within 48 hours of delivery, and rest/exercise echocardiography 12 weeks postpartum. Results Recruited subjects (n = 68) were grouped according to their blood pressure as: a) normotensive pregnancy n = 15; b) PreE with normotensive postpartum (PreE-Resolved, n = 36); c) PreE with persistent postpartum HTN (PreE-HTN, n = 17). At enrollment, a significantly higher percentage of subjects in the PreE-HTN group were Black. Compared to normotensive and PreE-Resolved subjects, those with PreE-HTN demonstrated higher resting systolic blood pressure (SBP, 112 [normotensive] vs 112 [PreE-Resolved] vs 134 [PreE-HTN], P < .001) and diastolic blood pressure (DBP, 70.0 vs 72.5 vs 85.0, P < .001), and significantly less postpartum weight loss (9.6% vs 13.6% vs 3.8%, P < .001). Following Bruce protocol stress testing, PreE-HTN subjects demonstrated achieved significantly lower exercise duration (10.4 vs 10.2 vs 7.9 minutes, P = .001). Subjects with PreE-HTN also demonstrated evidence of exercise-induced diastolic dysfunction as assessed by peak exercise lateral e' (18.0 vs 18.0 vs 13.5, P = .045) and peak exercise tricuspid regurgitation velocity (TR Vm, 2.4 vs 3.0 vs 3.1, P = 0.045). Exercise duration was negatively associated with gravidity (R = -0.27, P = .029) and postpartum LV mass index (R = -0.45, P < .001), resting average E/e' (R = -0.51, P < .001), BMI (R = -0.6, P < .001) and resting SBP (R = -0.51, P < .001). Conclusions Postpartum exercise stress testing capacity is related to readily available clinical markers including pregnancy factors, echocardiographic parameters and unresolved cardiometabolic risk factors.
C1 [Lindley, Kathryn J.; Huang, Shi; Shah, Ravi V.] Vanderbilt Univ, Med Ctr, Dept Med, Cardiovasc Div, Nashville, TN 37232 USA.
   [Lindley, Kathryn J.; Osmundson, Sarah] Vanderbilt Univ, Med Ctr, Dept Obstet & Gynecol, Nashville, TN 37232 USA.
   [Barker, Claire] Univ Toledo, Coll Med & Life Sci, Toledo, OH USA.
   [Mahmoud, Zainab; Lenzen, Patricia; Meyers, Rachel; Davila-Roman, Victor G.] Washington Univ, Dept Med, Cardiovasc Div, St Louis, MO USA.
   [Raghuraman, Nandini] Washington Univ, Dept Obstet & Gynecol, St Louis, MO USA.
C3 Vanderbilt University; Vanderbilt University; University System of Ohio;
   University of Toledo; Washington University (WUSTL); Washington
   University (WUSTL)
RP Lindley, KJ (corresponding author), Vanderbilt Univ, Sch Med, Cardiovasc Div, 1215 21st Ave South,Suite 5209, Nashville, TN 37232 USA.
EM Kathryn.lindley@vumc.org
RI Osmundson, Sarah/AGX-8036-2022; Lindley, Kathryn/MFH-6654-2025; Shah,
   Ravi/KLD-0068-2024
OI Lindley, Kathryn/0000-0002-8504-0006
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NR 26
TC 0
Z9 0
U1 2
U2 2
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0002-8703
EI 1097-6744
J9 AM HEART J
JI Am. Heart J.
PD SEP
PY 2024
VL 275
BP 192
EP 199
DI 10.1016/j.ahj.2024.06.002
EA AUG 2024
PG 8
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA C3R1Z
UT WOS:001288553000001
PM 38944263
OA hybrid
DA 2025-06-11
ER

PT J
AU Babic, D
   Martinac, M
   Bjelanovic, V
   Babic, R
   Sutovic, A
   Sinanovic, O
AF Babic, Dragan
   Martinac, Marko
   Bjelanovic, Vedran
   Babic, Romana
   Sutovic, Alija
   Sinanovic, Osman
TI Aggression in War Veterans Suffering from Posttraumatic Stress Disorder
   with Co-morbid Alcoholism
SO COLLEGIUM ANTROPOLOGICUM
LA English
DT Article
DE aggression; posttraumatic stress disorder; alcoholism
ID COMBAT VETERANS; METABOLIC SYNDROME; DEPENDENCE; SYMPTOMS; BEHAVIOR;
   VIOLENCE; VIETNAM; PTSD; ASSOCIATION; DEPRESSION
AB For thousands of years it has been known that aggression as a symptom appears in numerous psychiatric disorders and diseases. During the last decade the appearance of the aggressive behavior related to the posttraumatic stress disorder (PTSD) has been frequently investigated, often associated with war trauma. The goal of this study is to analyze the impact of alcoholism on a way war veterans suffering from chronic PTSD express and control aggression. The sample included 240 war veterans with chronic PTSD. The subjects were divided in two groups. PTSD group (n=147) and controlled group composed of those suffering from alcoholism in addition to PTSD (n=93). In this study, the following psychological instruments were used: The Harvard trauma questionnaire for PTSD diagnosis (HTQ); the questionnaire for self-evaluation of aggression (S TAXI); The Profile Index Emotion (PIE); questionnaire for auto-diagnosis of alcoholism (CAGE). The obtained results indicate that subjects who have PTSD with co-morbid alcoholism are more deprived, aggressive (p<0.001) and oppositional (p<0.05) in comparison to subjects whose PTSD is not combined with alcoholism (PIE). The aggression is statistically more expressed in subjects with PTSD who have also been diagnosed with alcoholism on all subscales in comparison to subjects with PTDS who have not been diagnosed with alcoholism: the current state of aggression, the general state of aggression, aggression towards an unfair treatment, aggression directed inwards and outwards (p<0.001); aggression towards nonspecific provocation and a general way of expressing aggression (p<0.05) (STAXI). Subjects that had PTSD combined with alcoholism show a higher degree of aggression in comparison to subjects with PTDS who are not diagnosed with alcoholism.
C1 [Babic, Dragan] Univ Hosp Mostar, Dept Psychiat, Mostar 88000, Bosnia & Herceg.
   [Martinac, Marko] Univ Mostar, Fac Med, Ctr Prevent & Outpatient Treatment Addict Mostar, Mostar, Bosnia & Herceg.
   [Bjelanovic, Vedran] Univ Hosp Mostar, Dept Gynecol, Mostar 88000, Bosnia & Herceg.
   [Babic, Romana] Univ Mostar, Fac Med, Mostar, Bosnia & Herceg.
   [Sutovic, Alija] Univ Tuzla, Fac Med, Inst Publ Hlth, Dept Psychiat, Tuzla, Bosnia & Herceg.
   [Sinanovic, Osman] Univ Tuzla, Fac Med, Publ Hlth Inst Tuzla, Dept Neurol, Tuzla, Bosnia & Herceg.
C3 University of Mostar; University of Mostar; University of Mostar;
   University of Mostar; University of Tuzla; University of Tuzla
RP Babic, D (corresponding author), Univ Hosp Mostar, Dept Psychiat, Mostar 88000, Bosnia & Herceg.
EM dragan.babic@tel.net.ba
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NR 34
TC 7
Z9 7
U1 0
U2 5
PU COLLEGIUM ANTROPOLOGICUM
PI ZAGREB
PA INST ANTHROPOLOGICAL RES, P O BOX 290, ULICA GRADA VUKOVARA 72/IV, 10000
   ZAGREB, CROATIA
SN 0350-6134
J9 COLLEGIUM ANTROPOL
JI Coll. Anthropol.
PD MAR
PY 2010
VL 34
SU 1
BP 23
EP 28
PG 6
WC Anthropology
WE Social Science Citation Index (SSCI)
SC Anthropology
GA 577OB
UT WOS:000276232100005
PM 20402291
DA 2025-06-11
ER

PT J
AU Uchio, R
   Muroyama, K
   Okuda-Hanafusa, C
   Kawasaki, K
   Yamamoto, Y
   Murosaki, S
AF Uchio, Ryusei
   Muroyama, Koutarou
   Okuda-Hanafusa, Chinatsu
   Kawasaki, Kengo
   Yamamoto, Yoshihiro
   Murosaki, Shinji
TI Hot Water Extract of Curcuma longa L. Improves Serum Inflammatory
   Markers and General Health in Subjects with Overweight or
   Prehypertension/Mild Hypertension: A Randomized, Double-Blind,
   Placebo-Controlled Trial
SO NUTRIENTS
LA English
DT Article
DE turmeric (Curcuma longa L.); bisacurone; turmeronol; chronic
   inflammation; C-reactive protein; glucose; hemoglobin A1c; high-density
   cholesterol; short-form 36-item health survey; profile of mood states
ID C-REACTIVE PROTEIN; LOW-GRADE INFLAMMATION; QUALITY-OF-LIFE; METABOLIC
   SYNDROME; INHIBITS ADHESION; ENDOTHELIAL-CELLS; OXIDATIVE STRESS;
   HEART-DISEASE; JAPANESE; RISK
AB To investigate the effect of a hot water extract of C. longa L. (WEC) containing anti-inflammatory agents, bisacurone, and turmeronol on chronic inflammation, a randomized double-blind placebo-controlled study was conducted in middle-aged and elderly subjects aged 50-69 years with overweight or prehypertension/mild hypertension. The subjects consumed 900 mg WEC tablets, containing 400 mu g bisacurone, 80 mu g turmeronol A and 20 mu g turmeronol B (WEC group: n = 45), or placebo tablets without WEC (placebo group: n = 45) daily for 12 weeks. Serum inflammatory and metabolic markers were measured. The subjects also completed the MOS 36-item short-form health survey (SF-36) and the Profile of Mood States scale (POMS). In the WEC group, the serum levels of C-reactive protein, tumor necrosis factor-alpha, interleukin-6, and soluble vascular cell adhesion molecule-1 decreased significantly. Compared with the placebo group, the WEC group had significantly lower serum levels of glucose, hemoglobin A1c, and triglycerides, as well as higher serum levels of high-density lipoprotein cholesterol. The WEC group also showed significant improvement of SF-36 scores (for general health, vitality, mental health, and mental summary component) and POMS scores for positive mood states (vigor-activity and friendliness). In conclusion, WEC may ameliorate chronic low-grade inflammation, thus contributing to the improvement of associated metabolic disorders and general health.
C1 [Uchio, Ryusei; Muroyama, Koutarou; Okuda-Hanafusa, Chinatsu; Kawasaki, Kengo; Yamamoto, Yoshihiro; Murosaki, Shinji] House Wellness Foods Corp, Res & Dev Inst, 3-20 Imoji, Itami, Hyogo 6640011, Japan.
RP Uchio, R (corresponding author), House Wellness Foods Corp, Res & Dev Inst, 3-20 Imoji, Itami, Hyogo 6640011, Japan.
EM uchio_ryusei@house-wf.co.jp
RI Uchio, Ryusei/X-2624-2019
OI Uchio, Ryusei/0000-0001-5924-4534
FU CRO company (CPCC Co., Ltd., Tokyo, Japan)
FX This study received no external funding and was conducted by a CRO
   company (CPCC Co., Ltd., Tokyo, Japan) under financial support from
   HouseWellness Foods Corp.
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NR 79
TC 26
Z9 27
U1 0
U2 14
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD AUG
PY 2019
VL 11
IS 8
AR 1822
DI 10.3390/nu11081822
PG 17
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nutrition & Dietetics
GA IV8HH
UT WOS:000484506000126
PM 31394768
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Asih, PR
   Tegg, ML
   Sohrabi, H
   Carruthers, M
   Gandy, SE
   Saad, F
   Verdile, G
   Ittner, LM
   Martins, RN
AF Asih, Prita R.
   Tegg, Michelle L.
   Sohrabi, Hamid
   Carruthers, Malcolm
   Gandy, Samuel E.
   Saad, Farid
   Verdile, Giuseppe
   Ittner, Lars M.
   Martins, Ralph N.
TI Multiple Mechanisms Linking Type 2 Diabetes and Alzheimer's Disease:
   Testosterone as a Modifier
SO JOURNAL OF ALZHEIMERS DISEASE
LA English
DT Review
DE Alzheimer's disease; men; testosterone; type-2 diabetes; women
ID C-REACTIVE PROTEIN; INSULIN-DEGRADING ENZYME; ANDROGEN-DEPRIVATION
   THERAPY; SEX STEROID-HORMONES; APOLIPOPROTEIN-E GENOTYPE;
   GROWTH-FACTOR-I; METABOLIC SYNDROME; OXIDATIVE STRESS; NEUROTROPHIC
   FACTOR; REPLACEMENT THERAPY
AB Evidence in support of links between type-2 diabetes mellitus (T2DM) and Alzheimer's disease (AD) has increased considerably in recent years. AD pathological hallmarks include the accumulation of extracellular amyloid-beta(A beta) and intracellular hyperphosphorylated tau in the brain, which are hypothesized to promote inflammation, oxidative stress, and neuronal loss. T2DM exhibits many AD pathological features, including reduced brain insulin uptake, lipid dysregulation, inflammation, oxidative stress, and depression; T2DM has also been shown to increase AD risk, and with increasing age, the prevalence of both conditions increases. In addition, amylin deposition in the pancreas is more common in AD than in normal aging, and although there is no significant increase in cerebral A beta deposition in T2DM, the extent of A beta accumulation in AD correlates withT2DMduration. Given these similarities and correlations, there may be common underlying mechanism(s) that predispose to both T2DM and AD. In other studies, an age-related gradual loss of testosterone and an increase in testosterone resistance has been shown in men; low testosterone levels can also occur in women. In this review, we focus on the evidence for low testosterone levels contributing to an increased risk of T2DM and AD, and the potential of testosterone treatment in reducing this risk in both men and women. However, such testosterone treatment may need to be long-term, and would need regular monitoring to maintain testosterone at physiological levels. It is possible that a combination of testosterone therapy together with a healthy lifestyle approach, including improved diet and exercise, may significantly reduce AD risk.
C1 [Asih, Prita R.; Ittner, Lars M.] Univ New South Wales, Sch Med Sci, Dementia Res Unit, Dept Anat, Sydney, NSW, Australia.
   [Asih, Prita R.; Martins, Ralph N.] KaRa Inst Neurol Dis, Sydney, NSW, Australia.
   [Tegg, Michelle L.; Sohrabi, Hamid; Martins, Ralph N.] Edith Cowan Univ, Sch Med & Hlth Sci, Perth, WA, Australia.
   [Sohrabi, Hamid; Verdile, Giuseppe; Martins, Ralph N.] Australian Alzheimers Res Fdn, Perth, WA, Australia.
   [Sohrabi, Hamid; Martins, Ralph N.] Macquarie Univ, Dept Biomed Sci, Sydney, NSW, Australia.
   [Sohrabi, Hamid; Martins, Ralph N.] Univ Western Australia, Sch Psychiat & Clin Neurosci, Perth, WA, Australia.
   [Carruthers, Malcolm] Ctr Mens Hlth, London, England.
   [Gandy, Samuel E.] Icahn Sch Med Mt Sinai, Dept Neurol, One Gustave L Levy Pl, New York, NY 10029 USA.
   [Gandy, Samuel E.] Icahn Sch Med Mt Sinai, Dept Psychiat, One Gustave L Levy Pl, New York, NY 10029 USA.
   [Gandy, Samuel E.] Icahn Sch Med Mt Sinai, Alzheimers Dis Res Ctr, One Gustave L Levy Pl, New York, NY 10029 USA.
   [Saad, Farid] Bayer Pharma AG, Global Med Affairs Androl, Berlin, Germany.
   [Saad, Farid] Gulf Med Univ, Sch Med, Ajman, U Arab Emirates.
   [Verdile, Giuseppe] Curtin Univ Technol, Sch Biomed Sci, Bentley, WA, Australia.
   [Ittner, Lars M.] Neurosci Res Australia, Sydney, NSW, Australia.
C3 University of New South Wales Sydney; KaRa Minds; Edith Cowan
   University; Macquarie University; University of Western Australia; Icahn
   School of Medicine at Mount Sinai; Icahn School of Medicine at Mount
   Sinai; Icahn School of Medicine at Mount Sinai; Bayer AG; Bayer
   Healthcare Pharmaceuticals; Curtin University; Neuroscience Research
   Australia
RP Martins, RN (corresponding author), Edith Cowan Univ, Ctr Excellence Alzheimers Dis Res & Care, Sch Med Sci, Joondalup, Australia.
EM r.martins@ecu.edu.au
RI Saad, Farid/AAW-2694-2020; Asih, Prita/ABE-6951-2020; Sohrabi, Hamid
   Reza/D-2744-2013
OI Ittner, Lars/0000-0001-6738-3825; Martins, Ralph/0000-0002-4828-9363;
   Verdile, Giuseppe/0000-0003-2475-0124; Sohrabi, Hamid
   Reza/0000-0001-8017-8682; Tegg, Michelle/0000-0003-4086-4156; Asih,
   Prita Riana/0000-0002-1973-9628
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NR 250
TC 27
Z9 30
U1 1
U2 21
PU IOS PRESS
PI AMSTERDAM
PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS
SN 1387-2877
EI 1875-8908
J9 J ALZHEIMERS DIS
JI J. Alzheimers Dis.
PY 2017
VL 59
IS 2
BP 445
EP 466
DI 10.3233/JAD-161259
PG 22
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology
GA FA9ZT
UT WOS:000405805400007
PM 28655134
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Thomson, EM
   Pal, S
   Guénette, J
   Wade, MG
   Atlas, E
   Holloway, AC
   Williams, A
   Vincent, R
AF Thomson, Errol M.
   Pal, Shinjini
   Guenette, Josee
   Wade, Michael G.
   Atlas, Ella
   Holloway, Alison C.
   Williams, Andrew
   Vincent, Renaud
TI Ozone Inhalation Provokes Glucocorticoid-Dependent and -Independent
   Effects on Inflammatory and Metabolic Pathways
SO TOXICOLOGICAL SCIENCES
LA English
DT Article
DE air pollution; ozone; glucocorticoid; stress response;
   hypothalamic-pituitary-adrenal (HPA) axis; systemic effects;
   inflammation; metabolic effects
ID EMERGENCY-DEPARTMENT VISITS; INHALED PARTICULATE MATTER; AMBIENT
   AIR-POLLUTION; LONG-TERM EXPOSURE; INSULIN-RESISTANCE; LUNG INJURY;
   STRESS; GENE; YOUNG; RESPONSIVENESS
AB Growing evidence implicates air pollutants in adverse health effects beyond respiratory and cardiovascular disease, including metabolic impacts (diabetes, metabolic syndrome, obesity) and neurological/neurobehavioral outcomes (neurodegenerative disease, cognitive decline, perceived stress, depression, suicide). We have shown that inhalation of particulate matter or ozone activates the hypothalamic-pituitary-adrenal axis in rats and increases plasma levels of the glucocorticoid corticosterone. To investigate the role of corticosterone in mediating inflammatory and metabolic effects of pollutant exposure, in this study male Fischer-344 rats were administered the 11 beta-hydroxylase inhibitor metyrapone (0, 50, 150 mg/kg body weight) and exposed by nose-only inhalation for 4h to air or 0.8ppm ozone. Ozone inhalation provoked a 2-fold increase in plasma corticosterone, an effect blocked by metyrapone, but did not alter epinephrine levels. Inhibition of corticosterone production was associated with increased inflammatory signaling in the lungs and plasma in response to ozone, consistent with a role for glucocorticoids in limiting local and systemic inflammatory responses. Effects of ozone on insulin and glucagon, but not ghrelin or plasminogen activator inhibitor-1, were modified by metyrapone, revealing glucocorticoid-dependent and - independent effects on circulating metabolic and hemostatic factors. Several immunosuppressive and metabolic impacts of ozone in the lungs, heart, liver, kidney, and spleen were blocked by metyrapone and reproduced through exogenous administration of corticosterone (10 mg/kg body weight), demonstrating glucocorticoid-dependent effects in target tissues. Our results support involvement of endogenous glucocorticoids in ozone-induced inflammatory and metabolic effects, providing insight into potential biological mechanisms underlying health impacts and susceptibility.
C1 [Thomson, Errol M.; Pal, Shinjini; Guenette, Josee; Wade, Michael G.; Atlas, Ella; Williams, Andrew; Vincent, Renaud] Hlth Canada, Environm Hlth Sci & Res Bur, Ottawa, ON K1A 0K9, Canada.
   [Holloway, Alison C.] McMaster Univ, Dept Obstet & Gynecol, Hamilton, ON L8N 3Z5, Canada.
C3 Health Canada; McMaster University
RP Thomson, EM (corresponding author), Hlth Canada, Hazard Identificat Div, Inhalat Toxicol Lab, Environm Hlth Sci & Res Bur, 0802B Tunneys Pasture, Ottawa, ON K1A 0K9, Canada.
EM errol.thomson@hc-sc.gc.ca
RI williams, anthony/HPE-7348-2023
OI Wade, Michael/0000-0002-7331-3839; Thomson, Errol/0000-0003-1295-5384;
   Williams, Andrew/0000-0002-7637-7686
FU Health Canada (Clean Air Regulatory Agenda) [810504]
FX This work was supported by Health Canada (Clean Air Regulatory Agenda,
   project 810504).
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NR 75
TC 61
Z9 64
U1 2
U2 24
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1096-6080
EI 1096-0929
J9 TOXICOL SCI
JI Toxicol. Sci.
PD JUL
PY 2016
VL 152
IS 1
BP 17
EP 28
DI 10.1093/toxsci/kfw061
PG 12
WC Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Toxicology
GA DT2AA
UT WOS:000381282000003
PM 27037194
OA Bronze
DA 2025-06-11
ER

PT J
AU Tu, WJ
   Qiu, HC
   Liu, Q
   Li, XM
   Zhao, JZ
   Zeng, XW
AF Tu, Wen-Jun
   Qiu, Han-Cheng
   Liu, Qiang
   Li, Xuemei
   Zhao, Ji-Zong
   Zeng, Xianwei
TI Decreased level of irisin, a skeletal muscle cell-derived myokine, is
   associated with post-stroke depression in the ischemic stroke population
SO JOURNAL OF NEUROINFLAMMATION
LA English
DT Article
DE Irisin; Depression; Acute ischemic stroke; Chinese
ID IMPROVES ENDOTHELIAL FUNCTION; CIRCULATING IRISIN; INSULIN-RESISTANCE;
   METABOLIC SYNDROME; ENERGY-METABOLISM; ADIPOSE-TISSUE; SERUM; EXERCISE;
   AMPK; ACTIVATION
AB Background: Depression is a frequent mood disorder in stroke patient. Our aim was to determine irisin levels in serum and investigate their associations with post-stroke depression (PSD) in a 6-month follow-up study in Chinese patients with first-ever acute ischemic stroke (AIS).
   Methods: The subjects were first-ever AIS patients who were hospitalized at three stroke centers during the period from January 2015 to December 2016. Neurological and neuropsychological evaluations were conducted at the 6-month follow-up. Serum irisin concentrations were measured by enzyme-linked immunosorbent assay (ELISA).
   Results: During the study period, 1205 patients were included in the analysis. There were 370 patients (30.7%) classified as depression. The depression distribution across the irisin quartiles ranged between 49.8% (first quartile) and 9.9% (fourth quartile). In the patients with depression, serum irisin levels were lower compared with those in patients without depression (P < 0.001). In a multivariate model using the first (Q1) quartile of irisin vs. Q2-4 together with the clinical variables, the marker displayed predictive information and increased risk of PSD by 75% (odds ratio [OR] for Q1, 1.75 [95% confidence interval [CI], 1.15-2.65]). In addition, a model containing known risk factors plus irisin compared with a model containing known risk factors without irisin showed a greater discriminatory ability; the area under the curve (AUC) increased from 0.77 to 0.81 (95% CI, 0.76-0.86).
   Conclusions: The data suggested that reduced serum levels of irisin were powerful biological markers of risk of developing PSD even after adjustment by variables. Further studies are necessary to confirm this association, which may open the way to the proposal of new therapeutic options.
C1 [Tu, Wen-Jun; Liu, Qiang] China Acad Med Sci, Inst Radiat Med, Tianjin, Peoples R China.
   [Tu, Wen-Jun; Liu, Qiang] Peking Union Med Coll, Tianjin, Peoples R China.
   [Tu, Wen-Jun; Qiu, Han-Cheng; Zhao, Ji-Zong] Capital Med Univ, Dept Neurosurg, Beijing Tiantan Hosp, Beijing, Peoples R China.
   [Tu, Wen-Jun; Li, Xuemei; Zeng, Xianwei] Weifang Med Univ, Inst Stroke, Ctr Translat Med, Weifang, Peoples R China.
C3 Chinese Academy of Medical Sciences - Peking Union Medical College;
   Institute of Radiation Medicine - CAMS; Chinese Academy of Medical
   Sciences - Peking Union Medical College; Peking Union Medical College;
   Capital Medical University; Shandong Second Medical University
RP Liu, Q (corresponding author), China Acad Med Sci, Inst Radiat Med, Tianjin, Peoples R China.; Liu, Q (corresponding author), Peking Union Med Coll, Tianjin, Peoples R China.; Zhao, JZ (corresponding author), Capital Med Univ, Dept Neurosurg, Beijing Tiantan Hosp, Beijing, Peoples R China.
EM liuqiang_cams@163.com; zhaojztj205@163.com
RI Tu, Wen-Jun/AAC-5696-2019; Liu, Qiang/AFK-6590-2022
OI Liu, Qiang/0000-0002-7668-6868
FU Shandong Province Science and Technology Development Plan Project
   [2015GGB14296]; Shandong Province Key Research and Development Projects
   [2016GSF201229]; National Natural Science Foundation of China
   [81671175]; CAMS Innovation Fund for Medical Science [2017-I2M-1-016]
FX This study was supported by grants from Shandong Province Science and
   Technology Development Plan Project (No. 2015GGB14296), Shandong
   Province Key Research and Development Projects (No. 2016GSF201229),
   National Natural Science Foundation of China (No. 81671175), and CAMS
   Innovation Fund for Medical Science (No. 2017-I2M-1-016).
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NR 54
TC 59
Z9 59
U1 0
U2 24
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1742-2094
J9 J NEUROINFLAMM
JI J. Neuroinflamm.
PD MAY 2
PY 2018
VL 15
AR 133
DI 10.1186/s12974-018-1177-6
PG 10
WC Immunology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Neurosciences & Neurology
GA GE9OB
UT WOS:000431557900004
PM 29720216
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Bai, YM
   Chiou, WF
   Su, TP
   Li, CT
   Chen, MH
AF Bai, Ya-Mei
   Chiou, Wen-Fei
   Su, Tung-Ping
   Li, Cheng-Ta
   Chen, Mu-Hong
TI Pro-inflammatory cytokine associated with somatic and pain symptoms in
   depression
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Pro-inflammatory cytokines; Somatic and pain symptoms; Depression
ID C-REACTIVE PROTEIN; ALPHA TNF-ALPHA; QUALITY-OF-LIFE; PLATELET
   ACTIVATION; PHYSICAL SYMPTOMS; P-SELECTIN; SOLUBLE
   INTERLEUKIN-2-RECEPTOR; PSYCHIATRIC OUTPATIENTS; METABOLIC SYNDROME;
   CHINESE PATIENTS
AB Background: More than two-thirds of depressed patients complain of somatic and pain symptoms, which are frequently regarded as a psychological reaction. Although there is a growing body of evidence showing that depression is related to immune abnormalities, few studies have investigated the association between inflammatory cytokines and somatic/pain symptoms.
   Method: Patients with depressive disorder but without any medical disorders, and age/gender/body mass index (BMI)-matched healthy subjects were enrolled. All the subjects completed the self-rating scales of the Beck Depression Inventory-II and the Depression and Somatic Symptoms Scale, which was comprised of depressive, somatic, and pain subscales. Pro-inflammatory cytokines, including C-reactive protein (CRP), interleukin-2 receptor (sIL-2R), soluble interleukin 6 receptor (sIL-6R), soluble TNF-receptors (sTNF-R), soluble P-selectin (sP-selectin), monocyte chemotactic protein-1 (MCP-1), and adiponectin, were assessed by enzyme linked immunosorbent assays.
   Results: In all, 109 patients with depressive disorder and 126 normal controls were enrolled. The patients with depressive disorder had significantly more severe depression, somatic and pain symptoms (all p <0.001), and higher levels of sIL-2R (p <0.0001), sTNF-R (p <0,001), and sP-selectin (p=0.005) than the normal control group. Using multivariate regression analysis with controlling of age, gender, BMI, and other pro inflammatory cytokines, sIL-2R was the most significant predictor for depressive symptoms (p <0.0001); with further controlling of severity of depressive symptom, sP-selectin was the only predictor for somatic (p=0.002) and pain (p=0.059) symptoms.
   Conclusion: The elevated sP-selectin associated with somatic symptoms in depression, may indicate early micro vascular changes occur subtly, and provide neurobiological evidence for somatic and pain symptom in depression. (C) 2013 Elsevier B.V. All rights reserved
C1 [Bai, Ya-Mei; Su, Tung-Ping; Li, Cheng-Ta; Chen, Mu-Hong] Taipei Vet Gen Hosp, Dept Psychiat, Taipei 11217, Taiwan.
   [Bai, Ya-Mei; Su, Tung-Ping; Li, Cheng-Ta] Natl Yang Ming Univ, Coll Med, Dept Psychiat, Taipei 112, Taiwan.
   [Chiou, Wen-Fei] Natl Res Inst Chinese Med, Taipei, Taiwan.
   [Chiou, Wen-Fei] Natl Taitung Univ, Inst Life Sci, Taitung, Taiwan.
   [Chiou, Wen-Fei] Natl Yang Ming Univ, Sch Med, Inst Tradit Med, Taipei 112, Taiwan.
C3 Taipei Veterans General Hospital; National Yang Ming Chiao Tung
   University; National Research Institute of Chinese Medicine; National
   Yang Ming Chiao Tung University
RP Bai, YM (corresponding author), Taipei Vet Gen Hosp, Dept Psychiat, 201 Shih Pai Rd,Sect 2, Taipei 11217, Taiwan.
EM ymbi@mail2000.com.tw
RI Li, Cheng-Ta/AAI-5759-2021; Chen, MuHong/ACJ-6131-2022
OI Li, Cheng-Ta/0000-0002-0670-1153
FU Taiwan National Science Council [NSC 99-2628-B-075-004-MY3, NSC
   102-2628-B-075-005-MY2]; Taipei Veterans General Hospital [V101C-063,
   V102C-057]
FX The study was supported by grants from Taiwan National Science Council
   (NSC 99-2628-B-075-004-MY3; NSC 102-2628-B-075-005-MY2), and Taipei
   Veterans General Hospital (V101C-063; V102C-057).
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NR 73
TC 65
Z9 70
U1 0
U2 22
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD FEB
PY 2014
VL 155
BP 28
EP 34
DI 10.1016/j.jad.2013.10.019
PG 7
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA 287XB
UT WOS:000329574500004
PM 24176538
DA 2025-06-11
ER

PT J
AU Keller, J
   Gomez, R
   Williams, G
   Lembke, A
   Lazzeroni, L
   Urphy, GM
   Schatzberg, AF
AF Keller, J.
   Gomez, R.
   Williams, G.
   Lembke, A.
   Lazzeroni, L.
   urphy, G. M., Jr.
   Schatzberg, A. F.
TI HPA axis in major depression: cortisol, clinical symptomatology and
   genetic variation predict cognition
SO MOLECULAR PSYCHIATRY
LA English
DT Article
ID MESSENGER-RNA EXPRESSION; MINERALOCORTICOID RECEPTOR;
   GLUCOCORTICOID-RECEPTOR; NEUROCOGNITIVE FUNCTION; MEMORY IMPAIRMENTS;
   METABOLIC SYNDROME; WORKING-MEMORY; ASSOCIATION; CORTICOSTEROIDS;
   POLYMORPHISMS
AB The hypothalamic-pituitary-adrenal (HPA) axis has been implicated in the pathophysiology of a variety of mood and cognitive disorders. Neuroendocrine studies have demonstrated HPA axis overactivity in major depression, a relationship of HPA axis activity to cognitive performance and a potential role of HPA axis genetic variation in cognition. The present study investigated the simultaneous roles HPA axis activity, clinical symptomatology and HPA genetic variation play in cognitive performance. Patients with major depression with psychotic major depression (PMD) and with nonpsychotic major depression (NPMD) and healthy controls (HC) were studied. All participants underwent a diagnostic interview and psychiatric ratings, a comprehensive neuropsychological battery, overnight hourly blood sampling for cortisol and genetic assessment. Cognitive performance differed as a function of depression subtype. Across all subjects, cognitive performance was negatively correlated with higher cortisol, and PMD patients had higher cortisol than did NPMDs and HCs. Cortisol, clinical symptoms and variation in genes, NR3C1 (glucocorticoid receptor; GR) and NR3C2 (mineralocorticoid receptor; MR) that encode for GRs and MRs, predicted cognitive performance. Beyond the effects of cortisol, demographics and clinical symptoms, NR3C1 variation predicted attention and working memory, whereas NR3C2 polymorphisms predicted memory performance. These findings parallel the distribution of GR and MR in primate brain and their putative roles in specific cognitive tasks. HPA axis genetic variation and activity were important predictors of cognition across the entire sample of depressed subjects and HR. GR and MR genetic variation predicted unique cognitive functions, beyond the influence of cortisol and clinical symptoms. GR genetic variation was implicated in attention and working memory, whereas MR was implicated in verbal memory.
C1 [Keller, J.; Gomez, R.; Lembke, A.; Lazzeroni, L.; urphy, G. M., Jr.; Schatzberg, A. F.] Stanford Univ, Sch Med, Dept Psychiat & Behav Sci, Stanford, CA USA.
   [Gomez, R.] Palo Alto Univ, Boston, MA USA.
   [Williams, G.] Brigham & Womens Hosp, Harvard Med Sch, Boston, MA USA.
C3 Stanford University; Harvard University; Harvard Medical School; Harvard
   University Medical Affiliates; Brigham & Women's Hospital
RP Keller, J (corresponding author), Stanford Univ, Sch Med, Dept Psychiat & Behav Sci, 401 Quarry Rd,Rm 2143, Stanford, CA 94305 USA.
EM jkeller@stanford.edu
RI Lazzeroni, Laura/F-2903-2010
OI Lazzeroni, Laura/0000-0002-1846-6920
FU Pritzker Foundation; NIH [MH50604, MH19938]; NIH/NCRR CTSA award [UL1
   RR025744]
FX Aspects of this study were supported by grants from the Pritzker
   Foundation, NIH MH50604 to Alan Schatzberg, NIH MH19938 to Alan
   Schatzberg, and NIH/NCRR CTSA award number UL1 RR025744. The clinical
   trial registration number was NCT00576095.
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NR 59
TC 586
Z9 656
U1 17
U2 227
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1359-4184
EI 1476-5578
J9 MOL PSYCHIATR
JI Mol. Psychiatr.
PD APR
PY 2017
VL 22
IS 4
BP 527
EP 536
DI 10.1038/mp.2016.120
PG 10
WC Biochemistry & Molecular Biology; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Biochemistry & Molecular Biology; Neurosciences & Neurology; Psychiatry
GA EP0TP
UT WOS:000397099900006
PM 27528460
OA Green Accepted
HC Y
HP N
DA 2025-06-11
ER

PT J
AU De Stefano, A
   Mannucci, L
   Tamburi, F
   Cardillo, C
   Schinzari, F
   Rovellas, V
   Nisticò, S
   Bennardo, L
   Di Daniele, N
   Tesauro, M
AF De Stefano, Alessandro
   Mannucci, Liliana
   Tamburi, Federica
   Cardillo, Carmine
   Schinzari, Francesca
   Rovellas, Valentina
   Nistico, Steven
   Bennardo, Luigi
   Di Daniele, Nicola
   Tesauro, Manfredi
TI Lp-PLA2, a new biomarker of vascular disorders in metabolic
   diseases
SO INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY
LA English
DT Article
DE biomarker; Lp-PLA(2); vascular inflammation
ID IMPROVES
AB Metabolic diseases are chronic disorders correlated to a greater risk of cardiovascular event and death. Recently, many data have sustained the biological link between microvascular dysfunction, oxidative stress, vascular inflammation, and metabolic diseases. The determination of new and specific blood biomarkers of vascular inflammation associated with obesity-related metabolic syndrome (MetS) and diabetes such as lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) could be useful to identify subject with high risk of cardiovascular events. Lp-PLA(2) participates by a crucial role in microvascular dysfunction and oxidative stress showing positive association with metabolic disorders. In this review, we will argue the evolving role of Lp-PLA(2) in predicting cardiovascular events in metabolic disease patients.
C1 [De Stefano, Alessandro; Rovellas, Valentina; Di Daniele, Nicola; Tesauro, Manfredi] Univ Roma Tor Vergata, Dept Syst Med, Rome, Italy.
   [Mannucci, Liliana] Univ Roma Tor Vergata, Dept Biomed & Prevent, Rome, Italy.
   [Tamburi, Federica; Cardillo, Carmine; Schinzari, Francesca] Univ Cattolica Sacro Cuore, Dept Internal Med, Rome, Italy.
   [Nistico, Steven; Bennardo, Luigi] Magna Graecia Univ Catanzaro, Dept Hlth Sci, Viale Europa, I-88100 Catanzaro, Italy.
C3 University of Rome Tor Vergata; University of Rome Tor Vergata; Catholic
   University of the Sacred Heart; IRCCS Policlinico Gemelli; Magna Graecia
   University of Catanzaro
RP Nisticò, S (corresponding author), Magna Graecia Univ Catanzaro, Dept Hlth Sci, Viale Europa, I-88100 Catanzaro, Italy.
EM steven.nistico@gmail.com
RI schinzari, francesca/AAB-9982-2019; Bennardo, Luigi/ABA-6474-2020
OI Mannucci, Liliana/0000-0003-2729-9957; Cardillo,
   Carmine/0000-0001-5182-3005; Nistico, Steven/0000-0002-3828-0883
CR Acevedo M, 2015, INT J ENDOCRINOL, V2015, DOI 10.1155/2015/934681
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NR 12
TC 35
Z9 36
U1 2
U2 8
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0394-6320
EI 2058-7384
J9 INT J IMMUNOPATH PH
JI Int. J. Immunopathol. Pharmacol.
PD FEB 1
PY 2019
VL 33
AR 2058738419827154
DI 10.1177/2058738419827154
PG 4
WC Immunology; Pathology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Pathology; Pharmacology & Pharmacy
GA HM6FT
UT WOS:000459570200001
PM 30706739
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Burke, A
   Lucey, MR
AF Burke, A
   Lucey, MR
TI Non-alcoholic fatty liver disease, non-alcoholic steatohepatitis and
   orthotopic liver transplantation
SO AMERICAN JOURNAL OF TRANSPLANTATION
LA English
DT Review
DE fatty liver disease; insulin resistance; liver transplantation; obesity;
   oxidative stress
ID OXIDATIVE STRESS; INSULIN-RESISTANCE; HEPATIC STEATOSIS;
   NATURAL-HISTORY; CRYPTOGENIC CIRRHOSIS; UNCOUPLING PROTEIN-2; PRIMARY
   NONFUNCTION; LIPID-PEROXIDATION; RISK-FACTORS; DONOR LIVER
AB Obesity, non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are becoming increasingly common medical problems in the developed world, often in the setting of the metabolic or insulin resistance syndrome (IRS). It is predicted that by the year 2025 > 25 million Americans may have NASH-related liver disease. NASH and NAFLD also affect the donor population. The use of steatotic donor livers for liver transplantation (LT) is associated with an increased risk of primary nonfunction (PNF) in the allograft. There is particular reluctance to use steatotic livers for living donor LT. There is indirect evidence to suggest that patients undergoing LT for cirrhosis resulting from NASH may have poorer outcome, despite careful selection of LT candidates. Indeed it is likely that many potential LT candidates with NASH are excluded from LT due to co-morbid conditions related to IRS. The post-LT patient is at risk of several components of IRS, such as diabetes mellitus, hypertension, hyperlipidaemia and obesity and there is increasing recognition of de novo and recurrent NAFLD and NASH after LT. Thus NAFLD and NASH affect all aspects of LT including donors, patients in evaluation and the LT recipient.
C1 Univ Wisconsin, Sch Med, Sect Gastroenterol & Hepatol, Madison, WI 53792 USA.
   Univ Penn, Sch Med, Div Gastroenterol, Philadelphia, PA 19104 USA.
C3 University of Wisconsin System; University of Wisconsin Madison;
   University of Pennsylvania
RP Univ Wisconsin, Sch Med, Sect Gastroenterol & Hepatol, Madison, WI 53792 USA.
EM mrl@medicine.wisc.edu
RI Lucey, Michael/AAR-4571-2020
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NR 78
TC 144
Z9 157
U1 0
U2 10
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1600-6135
EI 1600-6143
J9 AM J TRANSPLANT
JI Am. J. Transplant.
PD MAY
PY 2004
VL 4
IS 5
BP 686
EP 693
DI 10.1111/j.1600-6143.2004.00432.x
PG 8
WC Surgery; Transplantation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery; Transplantation
GA 818CT
UT WOS:000221223900005
PM 15084161
DA 2025-06-11
ER

PT J
AU Cazzola, M
   Bettoncelli, G
   Sessa, E
   Cricelli, C
   Biscione, G
AF Cazzola, Mario
   Bettoncelli, Germano
   Sessa, Emiliano
   Cricelli, Claudio
   Biscione, Gianluca
TI Prevalence of Comorbidities in Patients with Chronic Obstructive
   Pulmonary Disease
SO RESPIRATION
LA English
DT Article
DE Cardiovascular events; Chronic obstructive pulmonary disease;
   Depression; Osteoporosis
ID BONE-MINERAL DENSITY; CARDIOVASCULAR-DISEASE; SYSTEMIC INFLAMMATION;
   ARTERIAL STIFFNESS; METABOLIC SYNDROME; COPD; RISK; OSTEOPOROSIS;
   DEPRESSION; ANXIETY
AB Background: Chronic obstructive pulmonary disease (COPD) is associated with many comorbidities, but the percentage of COPD patients who develop comorbidities has not been clearly defined.
   Objectives: We aimed to examine the relationship between COPD and comorbidities using information obtained from the Health Search Database (HSD) owned by the Italian College of General Practitioners (SIMG), which stores information on about 1.5% of the total Italian population served by general practitioners.
   Methods: We conducted a population-based retrospective study using information obtained from the HSD. The software system used codes all the diagnostic records using the 9th Revision of the International Classification of Diseases.
   Results: Compared to the non-COPD people, COPD patients were at increased risk for cardiovascular events [ischemic heart disease (6.9% in the general population vs. 13.6% in COPD patients), cardiac arrhythmia (6.6% in the general population vs. 15.9% in COPD patients), heart failure (2.0% in the general population vs. 7.9% in COPD patients), and other forms of heart disease (10.7% in the general population vs. 23.1% in COPD patients); with a higher impact of COPD in the elderly]; non-psychotic mental disorders, including depressive disorders (29.1% in the general population vs. 41.6% in COPD patients; with a higher impact of COPD on women aged < 75 years); diabetes mellitus (10.5% in the general population vs. 18.7% in COPD patients); osteoporosis (10.8% in the general population vs. 14.8% in COPD patients), with a higher impact of COPD on women aged < 75 years, and malignant pulmonary neoplasms (0.4% in the general population vs. 1.9% in COPD patients).
   Conclusions: Our results indicate that COPD is a risk factor for these comorbid conditions. Copyright (C) 2010 S. Karger AG, Basel
C1 [Cazzola, Mario] Univ Roma Tor Vergata, Dipartimento Med Interna, Cattedra Malattie Resp, Div Resp Dis, IT-00133 Rome, Italy.
   [Cazzola, Mario] San Raffaele Pisana Hosp, Pulm Rehabil Grp, Rome, Italy.
   [Bettoncelli, Germano; Sessa, Emiliano; Cricelli, Claudio] Italian Coll Gen Practitioners, Hlth Search Inst, Florence, Italy.
   [Biscione, Gianluca] Hosp San Raffaele, Div Pulm Rehabil, Velletri, Italy.
C3 University of Rome Tor Vergata; Vita-Salute San Raffaele University;
   IRCCS Ospedale San Raffaele; Vita-Salute San Raffaele University; IRCCS
   Ospedale San Raffaele
RP Cazzola, M (corresponding author), Univ Roma Tor Vergata, Dipartimento Med Interna, Cattedra Malattie Resp, Div Resp Dis, Via Montpellier 1, IT-00133 Rome, Italy.
EM mario.cazzola@uniroma2.it
RI Cazzola, Mario/G-9397-2012; CRICELLI, Claudio/E-7607-2010
OI CRICELLI, Claudio/0000-0002-9607-5802
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NR 47
TC 163
Z9 168
U1 0
U2 10
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0025-7931
EI 1423-0356
J9 RESPIRATION
JI Respiration
PY 2010
VL 80
IS 2
BP 112
EP 119
DI 10.1159/000281880
PG 8
WC Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Respiratory System
GA 621OX
UT WOS:000279591100005
PM 20134148
OA Bronze
DA 2025-06-11
ER

PT J
AU Sánchez-Villegas, A
   Martínez-González, MA
   Estruch, R
   Salas-Salvadó, J
   Corella, D
   Covas, MI
   Arós, F
   Romaguera, D
   Gómez-Gracia, E
   Lapetra, J
   Pintó, X
   Martínez, JA
   Lamuela-Raventós, RM
   Ros, E
   Gea, A
   Wärnberg, J
   Serra-Majem, L
AF Sanchez-Villegas, Almudena
   Angel Martinez-Gonzalez, Miguel
   Estruch, Ramon
   Salas-Salvado, Jordi
   Corella, Dolores
   Isabel Covas, Maria
   Aros, Fernando
   Romaguera, Dora
   Gomez-Gracia, Enrique
   Lapetra, Jose
   Pinto, Xavier
   Alfredo Martinez, Jose
   Maria Lamuela-Raventos, Rosa
   Ros, Emilio
   Gea, Alfredo
   Waernberg, Julia
   Serra-Majem, Lluis
TI Mediterranean dietary pattern and depression: the PREDIMED randomized
   trial
SO BMC MEDICINE
LA English
DT Article
DE Mediterranean diet; Depression; Trial; Primary prevention; Nuts; Olive
   oil; Low-fat; Diabetes
ID BODY-MASS INDEX; METABOLIC SYNDROME; ENDOTHELIAL DYSFUNCTION;
   INSULIN-RESISTANCE; RISK-FACTORS; ASSOCIATION; SYMPTOMS; LEPTIN; WOMEN;
   METAANALYSIS
AB Background: A few observational studies have found an inverse association between adherence to a Mediterranean diet and the risk of depression. Randomized trials with an intervention based on this dietary pattern could provide the most definitive answer to the findings reported by observational studies. The aim of this study was to compare in a randomized trial the effects of two Mediterranean diets versus a low-fat diet on depression risk after at least 3 years of intervention.
   Methods: This was a multicenter, randomized, primary prevention field trial of cardiovascular disease (Prevencion con Dieta Mediterranea (PREDIMED Study)) based on community-dwelling men aged 55 to 80 years and women aged 60 to 80 years at high risk of cardiovascular disease (51% of them had type 2 diabetes; DM2) attending primary care centers affiliated with 11 Spanish teaching hospitals. Primary analyses were performed on an intention-to-treat basis. Cox regression models were used to assess the relationship between the nutritional intervention groups and the incidence of depression.
   Results: We identified 224 new cases of depression during follow-up. There was an inverse association with depression for participants assigned to a Mediterranean diet supplemented with nuts (multivariate hazard ratio (HR) 0.78; 95% confidence interval (CI) 0.55 to 1.10) compared with participants assigned to the control group, although this was not significant. However, when the analysis was restricted to participants with DM2, the magnitude of the effect of the intervention with the Mediterranean diet supplemented with nuts did reach statistical significance (multivariate HR = 0.59; 95% CI 0.36 to 0.98).
   Conclusions: The result suggest that a Mediterranean diet supplemented with nuts could exert a beneficial effect on the risk of depression in patients with DM2.
   Trial registration: This trial has been registered in the Current Controlled Trials with the number ISRCTN 35739639
C1 [Sanchez-Villegas, Almudena; Angel Martinez-Gonzalez, Miguel; Estruch, Ramon; Salas-Salvado, Jordi; Corella, Dolores; Isabel Covas, Maria; Aros, Fernando; Romaguera, Dora; Gomez-Gracia, Enrique; Lapetra, Jose; Pinto, Xavier; Alfredo Martinez, Jose; Maria Lamuela-Raventos, Rosa; Ros, Emilio; Gea, Alfredo; Waernberg, Julia; Serra-Majem, Lluis] Biomed Res Ctr Network Obes & Nutr CIBERobn Physi, Inst Hlth Carlos 3, Madrid, Spain.
   [Sanchez-Villegas, Almudena; Serra-Majem, Lluis] Univ Las Palmas Gran Canaria, Dept Clin Sci, Las Palmas Gran Canaria 35080, Spain.
   [Angel Martinez-Gonzalez, Miguel; Gea, Alfredo] Univ Navarra, Dept Prevent Med & Publ Hlth, E-31080 Pamplona, Spain.
   [Estruch, Ramon] Univ Barcelona, Hosp Clin, Inst Invest Biomed August Pi Sunyer IDIBAP, Dept Internal Med, Barcelona, Spain.
   [Salas-Salvado, Jordi] Univ Rovira & Virgili, IISPV, Human Nutr Unit, E-43201 Reus, Spain.
   [Corella, Dolores] Univ Valencia, Dept Prevent Med, Valencia, Spain.
   [Isabel Covas, Maria] IMIM, Lipids & Cardiovasc Epidemiol Res Unit, Barcelona, Spain.
   [Aros, Fernando] Univ Hosp Txagorritxu, Dept Cardiol, Vitoria, Spain.
   [Romaguera, Dora] Univ Hosp Son Espases, Res Unit, Palma de Mallorca, Spain.
   [Romaguera, Dora] Univ London Imperial Coll Sci Technol & Med, Sch Publ Hlth, London, England.
   [Gomez-Gracia, Enrique; Waernberg, Julia] Univ Malaga, Dept Prevent Med, E-29071 Malaga, Spain.
   [Lapetra, Jose] Ctr Salud San Pablo, Dept Family Med, Primary Care Div Sevilla, Seville, Spain.
   [Pinto, Xavier] Hosp Univ Bellvitge, Hosp Llobregat, Lipids & Vasc Risk Unit, Barcelona, Spain.
   [Alfredo Martinez, Jose] Univ Navarra, Dept Nutr & Food Sci Physiol & Toxicol, E-31080 Pamplona, Spain.
   [Maria Lamuela-Raventos, Rosa] Univ Barcelona, INSA, Nutr & Food Sci Dept XaRTA, Barcelona, Spain.
   [Ros, Emilio] Hosp Clin Barcelona, Lipid Clin, Dept Endocrinol & Nutr, Barcelona, Spain.
   [Ros, Emilio] Hosp Clin Barcelona, Inst Invest Biomed August Pi Sunyer IDIBAPS, Barcelona, Spain.
C3 CIBER - Centro de Investigacion Biomedica en Red; CIBEROBN; Universidad
   de Las Palmas de Gran Canaria; University of Navarra; University of
   Barcelona; Hospital Clinic de Barcelona; IDIBAPS; Universitat Rovira i
   Virgili; Institut d'Investigacio Sanitaria Pere Virgili (IISPV);
   University of Valencia; Hospital del Mar Research Institute; University
   Hospital of Araba; Hospital Universitari Son Espases; Imperial College
   London; Universidad de Malaga; Institut d'Investigacio Biomedica de
   Bellvitge (IDIBELL); Bellvitge University Hospital; University of
   Navarra; University of Barcelona; University of Barcelona; Hospital
   Clinic de Barcelona; University of Barcelona; Hospital Clinic de
   Barcelona; IDIBAPS
RP Sánchez-Villegas, A (corresponding author), Biomed Res Ctr Network Obes & Nutr CIBERobn Physi, Inst Hlth Carlos 3, Madrid, Spain.
EM asanchez@dcc.ulpgc.es
RI Romaguera, Dora/AAB-2852-2020; Sanchez-Villegas, Almudena/T-6733-2019;
   Warnberg, Julia/G-1390-2011; Salas-Salvado, Jordi/C-7229-2017; Raventos,
   Rosa/F-3986-2016; Corella, Dolores/L-9888-2014; Pintó,
   Xavier/AGI-4297-2022; Abad-Gurumeta, Alfredo/M-2337-2019;
   Martinez-Gonzalez, Miguel/AAE-7669-2019; Serra-Majem, Lluis/I-6708-2019;
   Lapetra, Jose/F-2552-2015; Estruch, Ramon/AAZ-3723-2020
FU official funding agency for biomedical research of the Spanish
   government, Instituto de Salud Carlos III (ISCIII) [RTIC G03/140, RTIC
   RD 06/0045]; Centro Nacional de Investigaciones Cardiovasculares [CNIC
   06/2007]; Fondo de Investigacion Sanitaria-Fondo Europeo de Desarrollo
   Regional [PI04-2239, PI 05/2584, CP06/00100, PI07/0240, PI07/1138,
   PI07/0954, PI 07/0473, PI10/01407, PI10/02658, PI11/01647, P11/02505];
   Ministerio de Ciencia e Innovacion [AGL-2009-13906-C02,
   AGL2010-22319-C03]; Fundacion Mapfre; Consejeria de Salud de la Junta de
   Andalucia [PI0105/2007]; Public Health Division of the Department of
   Health of the Autonomous Government of Catalonia; Generalitat Valenciana
   [ACOMP06109, GVACOMP2010-181, GVACOMP2011-151, CS2010- AP-111,
   CS2011-AP-042]; Regional Government of Navarra [P27/2011]; Spanish
   Government; official funding agency for biomedical research of the
   Spanish government, Instituto de Salud Carlos III (ISCIII), through
   Centro de Investigacion Biomedica en Red de Fisiopatologia de la
   Obesidad y Nutricion (CIBERobn)
FX This study was supported by the official funding agency for biomedical
   research of the Spanish government, Instituto de Salud Carlos III
   (ISCIII), through grants provided to research networks specifically
   developed for the trial (RTIC G03/140 to RE, RTIC RD 06/0045 to MAMG,
   and through Centro de Investigacion Biomedica en Red de Fisiopatologia
   de la Obesidad y Nutricion (CIBERobn), and by grants from Centro
   Nacional de Investigaciones Cardiovasculares (CNIC 06/2007), Fondo de
   Investigacion Sanitaria-Fondo Europeo de Desarrollo Regional (PI04-2239,
   PI 05/2584, CP06/00100, PI07/0240, PI07/1138, PI07/0954, PI 07/0473,
   PI10/01407, PI10/02658, PI11/01647, and P11/02505), Ministerio de
   Ciencia e Innovacion (AGL-2009-13906-C02 and AGL2010-22319-C03),
   Fundacion Mapfre 2010, Consejeria de Salud de la Junta de Andalucia
   (PI0105/2007), Public Health Division of the Department of Health of the
   Autonomous Government of Catalonia, Generalitat Valenciana (ACOMP06109,
   GVACOMP2010-181, GVACOMP2011-151, CS2010- AP-111, and CS2011-AP-042),
   and Regional Government of Navarra (P27/2011). AG is supported by an FPU
   fellowship from the Spanish Government.
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NR 57
TC 168
Z9 169
U1 2
U2 86
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1741-7015
J9 BMC MED
JI BMC Med.
PD SEP 20
PY 2013
VL 11
AR 208
DI 10.1186/1741-7015-11-208
PG 11
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 221HQ
UT WOS:000324649100001
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Hammer, T
   Kotolová, H
   Procházka, J
   Karpísek, M
AF Hammer, Tomas
   Kotolova, Hana
   Prochazka, Jiri
   Karpisek, Michal
TI Disruption of Lipid Profile, Glucose Metabolism, and Leptin Levels
   following Citalopram Administration and High-Carbohydrate and
   High-Cholesterol Diet in Mice
SO PHARMACOLOGY
LA English
DT Article
DE Adipokines; Citalopram; Dyslipidemia; Leptin; Metabolic syndrome; Mouse
ID SEROTONIN REUPTAKE INHIBITORS; PREMATURE EJACULATION; ESTROUS-CYCLE;
   DEPRESSION; ANXIETY; WEIGHT; ADIPONECTIN; EXPRESSION; SYMPTOMS; OBESITY
AB Introduction: Depression therapy has been linked to negative effects on energy metabolism, which can be attributed to various factors, including an ongoing inflammatory process commonly seen in metabolic disorders. Unhealthy lifestyle choices of patients and the impact of antidepressants on body weight and lipid and glucose metabolism also contribute to these metabolic side effects. Although not as pronounced as other psychopharmaceuticals, the increasing use of antidepressants raises concerns about their potential impact on public health. The study aimed to evaluate the short- and long-term effects of the antidepressant citalopram and its long-term combination with a special diet on metabolic parameters in mice. Methods: Animals were randomly divided into 5 groups - control, control + special diet, citalopram (10 mg/kg for 35 days), citalopram + special diet (10 mg/kg for 35 days), and citalopram (10 mg/kg for 7 days). After a described time of administration, animals were anesthetized, blood and fat and liver tissues were collected. Biochemical parameters of lipid metabolism (total cholesterol, HDL cholesterol, LDL cholesterol, triglycerides) and glucose were analyzed using spectrophotometry and relevant adipokines and cytokines were evaluated by ELISA. Results: After a week of application of citalopram, we observed dyslipidemia that persisted even at the end of the 5-week experiment. Furthermore, after 5 weeks of citalopram administration, we observed a significant decrease in body weight gain and decreased leptin levels. Changes in lipid metabolism, higher levels of adipokines leptin and PAI-1 were observed due to the special diet after 5 weeks. Conclusions: Our research suggests that the effects of citalopram and a diet on the metabolism of mice can be significant, both in the short term (1 week) and in the long term (5 weeks).
C1 [Hammer, Tomas; Kotolova, Hana; Prochazka, Jiri; Karpisek, Michal] Masaryk Univ, Fac Pharm, Dept Pharmacol & Toxicol, Brno, Czech Republic.
   [Hammer, Tomas; Kotolova, Hana; Prochazka, Jiri; Karpisek, Michal] Univ Vet & Pharmaceut Sci Brno, Fac Pharm, Dept Human Pharmacol & Toxicol, Brno, Czech Republic.
   [Karpisek, Michal] BioVendor Laboratorni Med A s, Res & Diagnost Prod Div, Brno, Czech Republic.
C3 Masaryk University Brno; University of Veterinary Sciences Brno
RP Hammer, T (corresponding author), Masaryk Univ, Fac Pharm, Dept Pharmacol & Toxicol, Brno, Czech Republic.; Hammer, T (corresponding author), Univ Vet & Pharmaceut Sci Brno, Fac Pharm, Dept Human Pharmacol & Toxicol, Brno, Czech Republic.
EM hammert@pharm.muni.cz
FU University of Veterinary and Pharmaceutical Sciences Brno [IGA
   316/2017/FAF]
FX This research was supported by project IGA 316/2017/FAF of the
   University of Veterinary and Pharmaceutical Sciences Brno.
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   Zemdegs J, 2016, BRIT J PHARMACOL, V173, P2095, DOI 10.1111/bph.13343
NR 42
TC 1
Z9 1
U1 1
U2 5
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0031-7012
EI 1423-0313
J9 PHARMACOLOGY
JI Pharmacology
PD APR
PY 2025
VL 110
IS 2
BP 87
EP 97
DI 10.1159/000541229
EA SEP 2024
PG 11
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 1QB2M
UT WOS:001324929200001
PM 39236683
OA hybrid
DA 2025-06-11
ER

PT J
AU Talbot, LS
   Neylan, TC
   Metzler, TJ
   Cohen, BE
AF Talbot, Lisa S.
   Neylan, Thomas C.
   Metzler, Thomas J.
   Cohen, Beth E.
TI The Mediating Effect of Sleep Quality on the Relationship between PTSD
   and Physical Activity
SO JOURNAL OF CLINICAL SLEEP MEDICINE
LA English
DT Article
DE posttraumatic stress disorder; sleep quality; physical activity
ID POSTTRAUMATIC-STRESS-DISORDER; CORONARY-HEART-DISEASE; NATIONALLY
   REPRESENTATIVE SAMPLE; METABOLIC SYNDROME; HEALTH BEHAVIORS;
   GENERAL-POPULATION; VIETNAM VETERANS; WEIGHT-GAIN; RISK; ASSOCIATION
AB Study Objectives: Physical inactivity is linked to health outcomes such as obesity, diabetes, and psychiatric disorders. Sleep disturbance has been linked to the same adverse outcomes. We examine the influence of sleep on physical activity as a novel approach to understand these relationships. Specifically, our objective was to determine whether low sleep quality predicts low physical activity in posttraumatic stress disorder (PTSD), a disorder associated with sleep disturbance, physical inactivity, and poor health outcomes.
   Methods: We used data from the Mind Your Heart Study, a prospective cohort study of 736 outpatients recruited from two Department of Veterans Affairs (VA) medical centers. We assessed PTSD with the Clinician Administered PTSD Scale, sleep quality using an item from the Pittsburgh Sleep Quality Index, and physical activity by self-report at baseline and again one year later. Hierarchical multiple regression models and structural equation modeling were used to examine the relationships among PTSD, sleep, and physical activity.
   Results: Sleep quality but not PTSD status was prospectively associated with lower physical activity in a model adjusting for age, sex, apnea probability, depression, body mass index, and baseline physical activity (beta = 0.129, SE = 0.072, p < 0.01). Structural equation modeling indicated that the results were consistent with sleep quality statistically mediating the relationship between PTSD status at baseline and physical activity one year later.
   Conclusions: Worse sleep quality predicts lower physical activity in PTSD, providing possible evidence for a behavioral pathway from disturbed sleep to poor physical health outcomes.
C1 [Talbot, Lisa S.; Neylan, Thomas C.; Metzler, Thomas J.; Cohen, Beth E.] San Francisco VA Med Ctr, San Francisco, CA USA.
   [Talbot, Lisa S.; Neylan, Thomas C.] Univ Calif San Francisco, Dept Psychiat, San Francisco, CA USA.
   [Cohen, Beth E.] Univ Calif San Francisco, Dept Med, San Francisco, CA USA.
C3 US Department of Veterans Affairs; Veterans Health Administration (VHA);
   San Francisco VA Medical Center; University of California System;
   University of California San Francisco; University of California System;
   University of California San Francisco
RP Talbot, LS (corresponding author), San Francisco VA Med Ctr 116H, 4150 Clement St, San Francisco, CA 94121 USA.
EM lisa.talbot@gmail.com
FU National Heart, Lung, and Blood Institute [K23 HL 094765]; Irene
   Perstein Foundation; Mental Illness Research and Education Clinical
   Center of the US Veterans Health Administration
FX This was not an industry supported study. This research was supported by
   grants from the National Heart, Lung, and Blood Institute (BEC: K23 HL
   094765), the Irene Perstein Foundation, and the Mental Illness Research
   and Education Clinical Center of the US Veterans Health Administration.
   The authors have indicated no financial conflicts of interest.
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NR 50
TC 43
Z9 49
U1 6
U2 34
PU AMER ACAD SLEEP MEDICINE
PI DARIEN
PA 2510 N FRONTAGE RD, DARIEN, IL 60561 USA
SN 1550-9389
EI 1550-9397
J9 J CLIN SLEEP MED
JI J. Clin. Sleep Med.
PY 2014
VL 10
IS 7
BP 795
EP 801
DI 10.5664/jcsm.3878
PG 7
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology
GA AO2GN
UT WOS:000341136100014
PM 25024659
OA Bronze, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Krogh, J
   Speyer, H
   Norgaard, HCB
   Moltke, A
   Nordentoft, M
AF Krogh, Jesper
   Speyer, Helene
   Norgaard, Hans Christian Brix
   Moltke, Ane
   Nordentoft, Merete
TI Can exercise increase fitness and reduce weight in patients with
   schizophrenia and depression?
SO FRONTIERS IN PSYCHIATRY
LA English
DT Article
DE exercise therapy; schizophrenia; depression; randomised controlled
   trials; weight loss
AB Background: Psychiatric patients have a reduced life expectancy of 15-20?years compared with the general population. Most years of lost life are due to the excess mortality from somatic diseases. Sedentary lifestyle and medication is partly responsible for the high frequency of metabolic syndrome in this patient group and low levels of physical activity is associated with increased risk of cardiovascular disease, diabetes, and all-cause mortality. This study aimed to review trials allocating patients with either schizophrenia or depression to exercise interventions for effect on cardiovascular fitness, strength, and weight.
   Methods: We searched PubMed, Embase, and PsycINFO including randomized clinical trial allocating patients with either schizophrenia or depression to isolated exercise interventions.
   Results: We identified five trials including patients with schizophrenia (n = 94) and found little evidence that exercise could increase cardiovascular fitness or decrease weight. Nine exercise trials for patients with depression (n = 892) were identified increasing cardiovascular fitness by 11-30% and strength by 33-37%. No evidence in favor of exercise for weight reduction was found.
   Conclusion: Based on the current evidence isolated exercise interventions are unlikely to improve cardiovascular fitness or induce weight loss in patients with schizophrenia. In patients with depression, exercise interventions are likely to induce clinically relevant short term effects, however, due to lack of reporting, little is known about the effect on weight reduction and cardiovascular fitness. Future exercise trials regarding patients with mental illness should preferably measure changes in cardiovascular strength, repetition maximum, and anthropometric outcomes. Ideally, participants should be assessed beyond the intervention to identify long lasting effects.
C1 [Krogh, Jesper; Speyer, Helene; Moltke, Ane; Nordentoft, Merete] Univ Copenhagen, Fac Hlth Sci, Mental Hlth Ctr Copenhagen, Copenhagen, Denmark.
   [Krogh, Jesper] Herlev Univ Hosp, Dept Endocrinol, Copenhagen, Denmark.
   [Norgaard, Hans Christian Brix] Aarhus Univ Hosp, Res Unit Dept P, Risskov, Denmark.
   [Moltke, Ane] Univ Roskilde, Res Ctr Hlth Promot, Roskilde, Denmark.
C3 University of Copenhagen; University of Copenhagen; Copenhagen
   University Hospital; Herlev & Gentofte Hospital; Aarhus University;
   Roskilde University
RP Nordentoft, M (corresponding author), Univ Copenhagen, Fac Hlth Sci, Mental Hlth Ctr Copenhagen, Copenhagen, Denmark.; Nordentoft, M (corresponding author), Bispebjerg Bakke 23, Copenhagen, Denmark.
EM mn@dadlnet.dk
RI speyer, helene/KGM-0671-2024; Nordentoft, Merete/AAH-3253-2019; Krogh,
   Jesper/C-6876-2013
OI Krogh, Jesper/0000-0003-4834-6724; Nordentoft,
   Merete/0000-0003-4895-7023; Brix Norgaard, Hans
   Christian/0000-0001-9985-1259
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NR 36
TC 23
Z9 24
U1 0
U2 10
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-0640
J9 FRONT PSYCHIATRY
JI Front. Psychiatry
PD JUL 28
PY 2014
VL 5
AR 89
DI 10.3389/fpsyt.2014.00089
PG 6
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA V46UD
UT WOS:000209908200001
PM 25120495
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Smith, JD
   Berkel, C
   Jordan, N
   Atkins, DC
   Narayanan, SS
   Gallo, C
   Grimm, KJ
   Dishion, TJ
   Mauricio, AM
   Rudo-Stern, J
   Meachum, MK
   Winslow, E
   Bruening, MM
AF Smith, Justin D.
   Berkel, Cady
   Jordan, Neil
   Atkins, David C.
   Narayanan, Shrikanth S.
   Gallo, Carlos
   Grimm, Kevin J.
   Dishion, Thomas J.
   Mauricio, Anne M.
   Rudo-Stern, Jenna
   Meachum, Mariah K.
   Winslow, Emily
   Bruening, Meg M.
TI An individually tailored family-centered intervention for pediatric
   obesity in primary care: study protocol of a randomized type II hybrid
   effectiveness-implementation trial (Raising Healthy Children study)
SO IMPLEMENTATION SCIENCE
LA English
DT Article
DE Family Check-Up 4 Health; Primary care; Hybrid
   effectiveness-implementation trial; Pediatric obesity; Integrated care;
   Coordinated care
ID BODY-MASS INDEX; CHILDHOOD-OBESITY; CHECK-UP; PHYSICAL-ACTIVITY;
   UNITED-STATES; BEHAVIORAL INTERVENTIONS; INSULIN-RESISTANCE;
   EARLY-ADOLESCENCE; MENTAL-HEALTH; RISK
AB Background: Pediatric obesity is a multi-faceted public health concern that can lead to cardiovascular diseases, cancers, and early mortality. Small changes in diet, physical activity, or BMI can significantly reduce the possibility of developing cardiometabolic risk factors. Family-based behavioral interventions are an underutilized, evidence-based approach that have been found to significantly prevent excess weight gain and obesity in children and adolescents. Poor program availability, low participation rates, and non-adherence are noted barriers to positive outcomes. Effective interventions for pediatric obesity in primary care are hampered by low family functioning, motivation, and adherence to recommendations.
   Methods: This (type II) hybrid effectiveness-implementation randomized trial tests the Family Check-Up 4 Health (FCU4Health) program, which was designed to target health behavior change in children by improving family management practices and parenting skills, with the goal of preventing obesity and excess weight gain. The FCU4Health is assessment driven to tailor services and increase parent motivation. A sample of 350 families with children aged 6 to 12 years who are identified as overweight or obese (BMI >= 85th percentile for age and gender) will be enrolled at three primary care clinics [two Federally Qualified Healthcare Centers (FQHCs) and a children's hospital]. All clinics serve predominantly Medicaid patients and a large ethnic minority population, including Latinos, African Americans, and American Indians who face disparities in obesity, cardiometabolic risk, and access to care. The FCU4Health will be coordinated with usual care, using two different delivery strategies: an embedded approach for the two FQHCs and a referral model for the hospital-based clinic. To assess program effectiveness (BMI, body composition, child health behaviors, parenting, and utilization of support services) and implementation outcomes (such outcomes as acceptability, adoption, feasibility, appropriateness, fidelity, and cost), we use a multi-method and multi-informant assessment strategy including electronic health record data, behavioral observation, questionnaires, interviews, and cost capture methods.
   Discussion: This study has the potential to prevent excess weight gain, obesity, and health disparities in children by establishing the effectiveness of the FCU4Health and collecting information critical for healthcare decision makers to support sustainable implementation of family-based programs in primary care.
C1 [Smith, Justin D.; Jordan, Neil; Gallo, Carlos; Meachum, Mariah K.] Northwestern Univ, Feinberg Sch Med, Dept Psychiat & Behav Sci, Chicago, IL 60611 USA.
   [Smith, Justin D.] Northwestern Univ, Feinberg Sch Med, Dept Prevent Med, Chicago, IL 60611 USA.
   [Smith, Justin D.] Northwestern Univ, Dept Pediat, Feinberg Sch Med, Chicago, IL 60611 USA.
   [Berkel, Cady; Grimm, Kevin J.; Dishion, Thomas J.; Mauricio, Anne M.; Rudo-Stern, Jenna; Winslow, Emily] Arizona State Univ, Dept Psychol, REACH Inst, Tempe, AZ 85287 USA.
   [Atkins, David C.] Univ Washington, Sch Med, Dept Psychiat & Behav Sci, Seattle, WA 98195 USA.
   [Narayanan, Shrikanth S.] Univ Southern Calif, Dept Elect Engn & Comp Sci, Los Angeles, CA USA.
   [Bruening, Meg M.] Arizona State Univ, Dept Nutr, Tempe, AZ USA.
C3 Northwestern University; Feinberg School of Medicine; Northwestern
   University; Feinberg School of Medicine; Northwestern University;
   Feinberg School of Medicine; Arizona State University; Arizona State
   University-Tempe; University of Washington; University of Washington
   Seattle; University of Southern California; Arizona State University;
   Arizona State University-Tempe
RP Smith, JD (corresponding author), Northwestern Univ, Feinberg Sch Med, Dept Psychiat & Behav Sci, Chicago, IL 60611 USA.; Smith, JD (corresponding author), Northwestern Univ, Feinberg Sch Med, Dept Prevent Med, Chicago, IL 60611 USA.
EM jd.smith@northwestern.edu
RI Rudo-Stern, Jenna/JXY-5835-2024; Mauricio, Anne Marie/LIF-2653-2024;
   Narayanan, Shrikanth/D-5676-2012; Berkel, Cady/A-1372-2010
OI Rudo-Stern, Jenna/0000-0002-6763-6308; Bruening,
   Meg/0000-0002-8301-8040; Atkins, David/0000-0002-5781-9880; Berkel,
   Cady/0000-0001-9664-9485
FU National Center for Chronic Disease Prevention and Health Promotion of
   the Centers of Disease Control and Prevention, under the Childhood
   Obesity Research Demonstration Project 2.0 (CORD) [U18 DP006255];
   National Institute on Drug Abuse [DA027828]; Implementation Research
   Institute (IRI) at the George Warren Brown School of Social Work,
   Washington University in St. Louis, through National Institute of Mental
   Health [R25 MH080916]; Implementation Research Institute (IRI) at the
   George Warren Brown School; College of Liberal Arts and Sciences at the
   Arizona State University
FX This study is supported by grant U18 DP006255 from the National Center
   for Chronic Disease Prevention and Health Promotion of the Centers of
   Disease Control and Prevention, under the Childhood Obesity Research
   Demonstration Project 2.0 (CORD), awarded to Cady Berkel and Justin
   Smith. Additional support was provided by grant DA027828 from the
   National Institute on Drug Abuse, awarded to C. Hendricks Brown, and by
   the Implementation Research Institute (IRI) at the George Warren Brown
   School of Social Work, Washington University in St. Louis, through grant
   R25 MH080916 from the National Institute of Mental Health and the
   Department of Veterans Affairs, Health Services Research and Development
   Service, Quality Enhancement Research Initiative (QUERI). The opinions
   expressed herein are the views of the authors and do not necessarily
   reflect the official policy or position of the Centers for Disease
   Control and Prevention, the Department of Veterans Affairs, the National
   Institute on Drug Abuse, the National Institute of Mental Health, or any
   other part of the US Department of Health and Human Services. The
   development work for this study was supported by a research grant from
   the College of Liberal Arts and Sciences at the Arizona State
   University, awarded to Thomas Dishion.
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NR 131
TC 41
Z9 45
U1 4
U2 38
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1748-5908
J9 IMPLEMENT SCI
JI Implement. Sci.
PD JAN 15
PY 2018
VL 13
AR 11
DI 10.1186/s13012-017-0697-2
PG 15
WC Health Care Sciences & Services; Health Policy & Services
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services
GA FS6JE
UT WOS:000419902900001
PM 29334983
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Ibrahim, HA
   El-Meligi, AA
   Abdel-Hamid, M
   Elhendy, A
AF Ibrahim, HA
   El-Meligi, AA
   Abdel-Hamid, M
   Elhendy, A
TI Relations between von Willebrand factor, markers of oxidative stress and
   microalbuminuria in patients with type 2 diabetes mellitus
SO MEDICAL SCIENCE MONITOR
LA English
DT Article
DE diabetes mellitus; oxidative stress; microalbuminurea; von Willebrand
   factor; coronary artery disease
ID INSULIN-RESISTANCE SYNDROME; INCREASED PLASMA-LEVELS; ENDOTHELIAL
   DYSFUNCTION; ALBUMIN EXCRETION; NIDDM PATIENTS; VITAMIN-C; DISEASE;
   RISK; MECHANISMS; MORTALITY
AB Background: To assess the relations among plasma levels of von Willebrand factor (vWf), microalbuminuria and markers of oxidative stress in patients with type 2 diabetes mellitus.
   Material/Methods: We studied 10 healthy subjects without microalbuminuria or history of coronary artery disease (CAD) and 30 patients with type 2 diabetes mellitus who were classified into three groups, each including 10 patients of matched age and sex; group 1: patients without microalbuminuria or history of CAD; group 2: patients with microalbuminuria and no history of CAD, and group 3: patients with microalbuminuria and history of CAD. All subjects underwent laboratory measurements of vWf, albumin excretion rate (AER), malondialdehyde, vitamin C, reduced glutathione and C peptide.
   Results: vWf was elevated in patients with type 2 diabetes mellitus compared with control subjects. However, levels were higher in patients with than without microalbuminuria and in patients with than without a history of CAD (96 +/- 12, 124 +/- 7, 149 +/- 9, 175 +/- 7 in the control subjects and the diabetic patients' groups respectively). There was a positive correlation between vWf and AER, MDA and C- peptide (r = 0.91, 0.98, 0.96, p < 0.0001) and a negative correlation between vWf and both vitamin C and reduced glutathione (r = -0.59 and -0.62 respectively, p < 0.001).
   Conclusions: vWf levels are elevated in patients with type 2 diabetes mellitus, particularly in the presence of microalbuminuria and history of CAD. vWf levels are associated with markers of increased oxidative stress and therefore reflect the severity of biochemical abnormalities, which contribute to diabetic vascular disease.
C1 Univ Nebraska, Med Ctr, Dept Internal Med, Omaha, NE 68198 USA.
   Cairo Univ Hosp, Dept Internal Med, Cairo, Egypt.
   Cairo Univ Hosp, Dept Cardiol, Cairo, Egypt.
C3 University of Nebraska System; University of Nebraska Medical Center;
   Egyptian Knowledge Bank (EKB); Cairo University; Cairo University
   Hospital; Egyptian Knowledge Bank (EKB); Cairo University; Cairo
   University Hospital
RP Univ Nebraska, Med Ctr, Dept Internal Med, 982055, Omaha, NE 68198 USA.
EM aelhendy@unmc.edu
RI ElMeligi, Dr Amin/LMP-0828-2024
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NR 29
TC 18
Z9 19
U1 0
U2 0
PU INT SCIENTIFIC INFORMATION, INC
PI MELVILLE
PA 150 BROADHOLLOW RD, STE 114, MELVILLE, NY 11747 USA
SN 1643-3750
J9 MED SCI MONITOR
JI Med. Sci. Monitor
PD MAR
PY 2004
VL 10
IS 3
BP CR85
EP CR89
PG 5
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 867HC
UT WOS:000224832100006
PM 14976459
DA 2025-06-11
ER

PT J
AU Panting, JR
   Gatehouse, PD
   Yang, GZ
   Grothues, F
   Firmin, DN
   Collins, P
   Pennell, DJ
AF Panting, JR
   Gatehouse, PD
   Yang, GZ
   Grothues, F
   Firmin, DN
   Collins, P
   Pennell, DJ
TI Abnormal subendocardial perfusion in cardiac syndrome X detected by
   cardiovascular magnetic resonance imaging
SO NEW ENGLAND JOURNAL OF MEDICINE
LA English
DT Article
ID NORMAL CORONARY ARTERIOGRAMS; LEFT-VENTRICULAR FUNCTION; MYOCARDIAL
   BLOOD-FLOW; ANGINA-PECTORIS; CHEST-PAIN; ARTERY-DISEASE; VASODILATOR
   RESERVE; LACTATE PRODUCTION; ISCHEMIA; DYSFUNCTION
AB Background: In cardiac syndrome X (a syndrome characterized by typical angina, abnormal exercise-test results, and normal coronary arteries), conventional investigations have not found that chest pain is due to myocardial ischemia. Magnetic resonance techniques have higher resolution and therefore may be more sensitive.
   Methods: We performed myocardial-perfusion cardiovascular magnetic resonance imaging in 20 patients with syndrome X and 10 matched controls, both at rest and during an infusion of adenosine. Quantitative perfusion analysis was performed by using the normalized upslope of myocardial signal enhancement to derive the myocardial perfusion index and the myocardial-perfusion reserve index (defined as the ratio of the myocardial perfusion index during stress to the index at rest).
   Results: In the controls, the myocardial perfusion index increased in both myocardial layers with adenosine (in the subendocardium, from a mean [+/-SD] of 0.12+/-0.03 to 0.16+/-0.03 [P=0.02]; in the subepicardium, from 0.11+/-0.02 to 0.17+/-0.05 [P=0.002]); in patients with syndrome X, the myocardial perfusion index did not change significantly in the subendocardium (0.13+/-0.02 vs. 0.14+/-0.03, P=0.11; P=0.09 as compared with controls) but increased in the subepicardium (from 0.11+/-0.02 to 0.20+/-0.04, P<0.001; P=0.11 for the comparison with controls). Adenosine provoked chest pain in 95 percent of patients with syndrome X and 40 percent of controls (P<0.001).
   Conclusions: In patients with syndrome X, cardiovascular magnetic resonance imaging demonstrates subendocardial hypoperfusion during the intravenous administration of adenosine, which is associated with intense chest pain. These data support the notion that the chest pain may have an ischemic cause.
C1 Royal Brompton Hosp, Cardiovasc Magnet Resonance Unit, London SW3 6NP, England.
   Royal Brompton Hosp, Dept Cardiovasc Med, London SW3 6NP, England.
   Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, London, England.
   Univ London Imperial Coll Sci Technol & Med, Dept Comp, London, England.
C3 Royal Brompton Hospital; Royal Brompton Hospital; Imperial College
   London; Imperial College London
RP Royal Brompton Hosp, Cardiovasc Magnet Resonance Unit, Sydney St, London SW3 6NP, England.
OI Pennell, Dudley/0000-0001-5523-1314; Firmin, David/0000-0003-3894-7489;
   Gatehouse, Peter/0000-0002-0260-4719
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TC 569
Z9 603
U1 1
U2 11
PU MASSACHUSETTS MEDICAL SOC
PI WALTHAM
PA WALTHAM WOODS CENTER, 860 WINTER ST,, WALTHAM, MA 02451-1413 USA
SN 0028-4793
EI 1533-4406
J9 NEW ENGL J MED
JI N. Engl. J. Med.
PD JUN 20
PY 2002
VL 346
IS 25
BP 1948
EP 1953
DI 10.1056/NEJMoa012369
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 563QC
UT WOS:000176266200003
PM 12075055
OA Bronze
DA 2025-06-11
ER

PT J
AU Chirinos, DA
   Kershaw, KN
   Allen, NB
   Carroll, AJ
   Lewis, TT
   Schreiner, PJ
   Lewis, CE
   Kiefe, CI
   Mezuk, B
   Carnethon, MR
AF Chirinos, Diana A.
   Kershaw, Kiarri N.
   Allen, Norrina B.
   Carroll, Allison J.
   Lewis, Tene T.
   Schreiner, Pamela J.
   Lewis, Cora E.
   Kiefe, Catarina I.
   Mezuk, Briana
   Carnethon, Mercedes R.
TI Depressive Symptom Subgroups and Their Association with Prevalent and
   Incident Cardiovascular Risk Factors in the Coronary Artery Risk
   Development in Young Adults (CARDIA) Study
SO INTERNATIONAL JOURNAL OF BEHAVIORAL MEDICINE
LA English
DT Article
DE Depression; Cardiovascular risk factors; Obesity; Diabetes;
   Hypertension; Cardiovascular disease
ID RANDOMIZED CONTROLLED-TRIAL; PROBLEM-SOLVING THERAPY; WEIGHT-LOSS
   TREATMENT; METABOLIC SYNDROME; COMORBID OBESITY; POSITIVE AFFECT;
   OLDER-ADULTS; ANXIETY; HYPERTENSION; WOMEN
AB Background We sought to identify depressive symptom subgroups in a community sample of young adults, investigate their stability over time, and determine their association with prevalent and incident cardiovascular disease (CVD) risk factors. Method Participants were 3377 adults from the Coronary Artery Risk Development in Young Adults study. Using latent class and latent transition analysis, we derived subgroups based on items of the 20-item version of the Center for Epidemiologic Studies Depression Scale in 1990, and examined patterns of change over a 10-year period (1990-2000). Cox regression models were used to examine associations between subgroup membership and prevalent (2000) and incident (2000 to 2016) obesity, hypertension, and diabetes. Results Three baseline subgroups were identified and labeled: "No Symptoms" (63.5%), "Lack of Positive Affect" (PA, 25.6%), and "Depressed Mood" (10.9%). At 10-year follow-up, individuals in "No Symptoms" subgroup had the highest probability (0.84) of being classified within the same subgroup. Participants classified as "Lack of PA" were likely (0.46) to remain in the same subgroup or be classified as "No Symptoms." Participants in the "Depressed Mood" were most likely to transition to the "Lack of PA" subgroup (0.38). Overall, 30.5% of participants transitioned between subgroups, with 11.4% classified as "Worsening" and 19.1% as "Improving." Relative to the "No Symptoms Stable," other subgroups ("Depressed Stable," "Worsening," and "Improving") were associated with prevalent obesity and hypertension. Conclusion We identified distinct depressive symptom subgroups that are variably stable over time, and their change patterns were differentially associated with CVD risk factor prevalence.
C1 [Chirinos, Diana A.; Kershaw, Kiarri N.; Allen, Norrina B.; Carnethon, Mercedes R.] Northwestern Univ, Dept Prevent Med, Feinberg Sch Med, 680 N Lakeshore Dr,Suite 1400, Chicago, IL 60611 USA.
   [Carroll, Allison J.] Northwestern Univ, Dept Cardiac Surg, Feinberg Sch Med, Chicago, IL USA.
   [Lewis, Tene T.] Emory Univ, Rollins Sch Publ Hlth, Dept Epidemiol, Atlanta, GA USA.
   [Schreiner, Pamela J.] Univ Minnesota, Div Epidemiol & Community Hlth, Minneapolis, MN USA.
   [Lewis, Cora E.] Univ Alabama Birmingham, Dept Epidemiol, Birmingham, AL USA.
   [Kiefe, Catarina I.] Univ Massachusetts, Dept Populat & Quantitat Hlth Sci, Med Sch, Worcester, MA USA.
   [Mezuk, Briana] Univ Michigan, Dept Epidemiol, Ann Arbor, MI USA.
C3 Northwestern University; Feinberg School of Medicine; Northwestern
   University; Feinberg School of Medicine; Emory University; Rollins
   School Public Health; University of Minnesota System; University of
   Minnesota Twin Cities; University of Alabama System; University of
   Alabama Birmingham; University of Massachusetts System; University of
   Massachusetts Worcester; University of Michigan System; University of
   Michigan
RP Chirinos, DA (corresponding author), Northwestern Univ, Dept Prevent Med, Feinberg Sch Med, 680 N Lakeshore Dr,Suite 1400, Chicago, IL 60611 USA.
EM diana.chirinos@northwestern.edu
RI Lewis, Tene/JBS-7332-2023; Mezuk, Briana/AAY-5321-2020; Carroll,
   Allison/JOK-2424-2023
OI Schreiner, Pamela/0000-0002-9920-6257
FU National Heart, Lung, and Blood Institute (NHLBI) [HHSN268201800003I,
   HHSN268201800004I, HHSN268201800005I, HHSN268201800006I,
   HHSN268201800007I]; NHLBI [1K01HL149987-01A1]
FX The Coronary Artery Risk Development in Young Adults Study (CARDIA) is
   supported by contracts HHSN268201800003I, HHSN268201800004I,
   HHSN268201800005I, HHSN268201800006I, and HHSN268201800007I from the
   National Heart, Lung, and Blood Institute (NHLBI). DC is supported by
   1K01HL149987-01A1 from the NHLBI.
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NR 56
TC 4
Z9 4
U1 0
U2 7
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1070-5503
EI 1532-7558
J9 INT J BEHAV MED
JI Int. J. Behav. Med.
PD DEC
PY 2023
VL 30
IS 6
BP 891
EP 903
DI 10.1007/s12529-022-10144-z
EA JAN 2023
PG 13
WC Psychology, Clinical
WE Social Science Citation Index (SSCI)
SC Psychology
GA AZ2S3
UT WOS:000917920500001
PM 36670342
DA 2025-06-11
ER

PT J
AU Demirci, OO
   Fistikci, N
   Sagaltici, E
   Karamustafalioglu, N
   Yildirim, A
   Ilnem, MC
AF Demirci, Onur Okan
   Fistikci, Nurhan
   Sagaltici, Eser
   Karamustafalioglu, Nesrin
   Yildirim, Abdullah
   Ilnem, Mehmet Cem
TI Metabolic parameters in patients with major depression treated with
   escitalopram
SO ANADOLU PSIKIYATRI DERGISI-ANATOLIAN JOURNAL OF PSYCHIATRY
LA English
DT Article
DE major depression; metabolic syndrome; metabolic parameters; selective
   serotonin reuptake inhibitors; escitalopram
ID ANTIDEPRESSANT MEDICATION USE; WEIGHT-GAIN; BODY-WEIGHT; RISK
AB Objective: The aim of this study is to determine the change in metabolic parameters of patients with major depression treated with escitalopram. Methods: The height, body weight, waist circumference, blood pressure, lipid profile (total cholesterol, low density lipoprotein [LDL], high density lipoprotein [HDL], triglycerides [TG]), fasting blood glucose (FBG), thyroid stimulating hormone (TSH) and Hamilton Depression Scale (HamD) of 41 consecutively selected patients with major depression were measured before treatment and in the third month of treatment, for whom a decision to start treatment with escitalopram was decided. The relationship between treatment and changes in these metabolic parameters were evaluated at the end of this period. Results: The mean age of patients was 30.24 +/- 9.96 (18-62) years. Eleven (27%) patients were male and 30 (73%) were female. Twelve (29.3%) patients were treated with 10 mg/day escitalopram, and 29 patients (70.7%) 20 mg/day. Significant increases were detected in body weight, body mass index, waist circumference and systolic blood pressures of all patients from initiation of treatment to three months. A significant increase was found in the waist circumference of male patients (n= 11) after three months of treatment. Body weight, body mass index, waist circumference, triglycerides, systolic blood pressure were found to be significantly increased after three months of treatment in female patients (n= 30) who were treated with escitalopram. HamD scores were found to be significantly decreased after three months in patients treated with escitalopram. Conclusion: Escitalopram caused an increase in especially body weight and waist circumference in patients with major depression.
C1 [Demirci, Onur Okan] Tatvan State Hosp, Tatvan, Bitlis, Turkey.
   [Fistikci, Nurhan; Karamustafalioglu, Nesrin; Ilnem, Mehmet Cem] Bakirkoy Res & Training Hosp Psychiat Neurol & Ne, Dept Psychiat, Istanbul, Turkey.
   [Sagaltici, Eser] Bitlis State Hosp, Bitlis, Turkey.
   [Yildirim, Abdullah] Van Yuzuncu Yil Univ, Med Ctr, Dept Psychiat, Van, Turkey.
C3 Tatvan State Hospital; Istanbul Bakirkoy Mental Health & Neurology
   Training & Research Hospital; Bitlis State Hospital; Yuzuncu Yil
   University
RP Demirci, OO (corresponding author), Tatvan Devlet Hastanesi, Psikiyatri Poliklin, Tatvan Bitlis, Turkey.
EM oo_demirci@yahoo.com
RI Yıldırım, Abdullah/C-4921-2019; ilnem, mehmet/AAL-1920-2020; Demirci,
   Onur/V-4438-2017; Sağaltıcı, Eser/AAT-3056-2020
OI Ilnem, Mehmet Cem/0000-0003-1614-9056; Sagaltici,
   Eser/0000-0002-4217-2658
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NR 18
TC 1
Z9 2
U1 0
U2 7
PU CUMHURIYET UNIV TIP FAK PSIKIYATRI ANABILIM DALI
PI SIVAS
PA CUMHURIYET UNIV TIP FAK PSIKIYATRI ABD, SIVAS, 58140, TURKEY
SN 1302-6631
J9 ANADOLU PSIKIYATR DE
JI Anadolu Psikiyatr. Derg.
PD DEC
PY 2016
VL 17
IS 6
BP 482
EP 488
DI 10.5455/apd.214058
PG 7
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychiatry
GA EH2AC
UT WOS:000391568600008
DA 2025-06-11
ER

PT J
AU Oxenkrug, G
AF Oxenkrug, Gregory
TI Interferon-gamma - Inducible Inflammation: Contribution to Aging and
   Aging-Associated Psychiatric Disorders
SO AGING AND DISEASE
LA English
DT Review
DE Interferon-gamma; Aging; Inflammation; Neopterin; Kynurenines;
   Depression; Insulin resistance; Obesity; Metabolic syndrome
ID INDOLEAMINE 2,3-DIOXYGENASE ACTIVITY; SINGLE NUCLEOTIDE POLYMORPHISM;
   N-ACETYLSEROTONIN; TRYPTOPHAN-METABOLISM; DEPRESSIVE DISORDER;
   KYNURENINE PATHWAY; CIRCADIAN-RHYTHMS; IMMUNE ACTIVATION;
   GENE-EXPRESSION; MESSENGER-RNA
AB Aging is associated with the chronic, low grade, Th-1 type inflammation. The key Th-1 type, pro-inflammatory cytokine, interferon-gamma (IFNG), transcriptionally induces the rate-limiting enzyme of tryptophan (TRY) - kynurenine (KYN) pathway, indoleamine 2,3-dioxygenase (IDO). Activation of IDO shunts TRY metabolism from production of serotonin (substrate of antidepressant effect) and its derivatives: N-acetylserotonin (an agonist to the receptors of brain derived neurotropic factor), and melatonin (regulator of sleep and other circadian rhythms), towards production of KYN and its derivatives (anxiogenic, neurotoxic and pro-oxidant factors). Some of kynurenines up-regulate nitric oxide synthase (NOS). Concurrently with activation of IDO, IFNG induces guanosine triphosphate cyclohydrolase I (GTPCH), the rate limiting enzyme of GTP conversion into BH2 (and increases formation of a stable derivative of BH2, neopterin, at the expense of production of BH4, the mandatory co-factor of NOS). Combination of increased NOS activity (by kynurenines) with decreased formation of BH4 leads to the uncoupling of NOS with consequent shift of arginine metabolism from biosynthesis of NO to formation of superoxide anion and other free radicals, and exacerbation of depression, anxiety and cognitive impairment caused by kynurenines. Polymorphism of IFNG (+874) T/A gene, that encodes production of IFNG protein, impacts the IDO and GTPCH activity that might be assessed in humans by KYN/TRY ratio and neopterin concentrations in biological fluids (e. g., blood, urine and spinal fluid). The hypothesis of IFNG inducible IDO/GTPCH inflammation cascade helps to understand the increased association between aging, inflammation and aging-associated psychiatric and medical (insulin resistance, obesity) disorders. Evaluation of markers of IFNG-inducible inflammation cascade might be used to assess the severity of corresponding behavioral and cognitive changes and the efficacy of pharmacological interventions (e. g., IDO inhibitors).
C1 [Oxenkrug, Gregory] Tufts Univ, Sch Med, Psychiat & Inflammat Program, Dept Psychiat,Tufts Med Ctr, Boston, MA 02111 USA.
C3 Tufts University; Tufts Medical Center
RP Oxenkrug, G (corresponding author), Tufts Univ, Sch Med, Psychiat & Inflammat Program, Tufts Med Ctr, Boston, MA 02111 USA.
EM goxenkrug@tuftsmedicalcenter.org
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NR 110
TC 49
Z9 51
U1 1
U2 10
PU INT SOC AGING & DISEASE
PI FORT WORTH
PA EDITORIAL OFF, 3400 CAMP BOWIE BLVD, FORT WORTH, TX 76106 USA
SN 2152-5250
J9 AGING DIS
JI Aging Dis.
PD DEC
PY 2011
VL 2
IS 6
BP 474
EP 486
PG 13
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA V32KS
UT WOS:000208950700005
PM 22396896
DA 2025-06-11
ER

PT J
AU Hall, JA
   Dominy, JE
   Lee, Y
   Puigserver, P
AF Hall, Jessica A.
   Dominy, John E.
   Lee, Yoonjin
   Puigserver, Pere
TI The sirtuin family's role in aging and age-associated pathologies
SO JOURNAL OF CLINICAL INVESTIGATION
LA English
DT Review
ID FATTY-ACID OXIDATION; CALORIE RESTRICTION; GENE-EXPRESSION; HISTONE H3;
   IN-VIVO; SIRT3-MEDIATED DEACETYLATION; MITOCHONDRIAL-FUNCTION;
   ENERGY-EXPENDITURE; TUMOR-SUPPRESSOR; MAMMALIAN SIR2
AB The 7 mammalian sirtuin proteins compose a protective cavalry of enzymes that can be invoked by cells to aid in the defense against a vast array of stressors. The pathologies associated with aging, such as metabolic syndrome, neurodegeneration, and cancer, are either caused by or exacerbated by a lifetime of chronic stress. As such, the activation of sirtuin proteins could provide a therapeutic approach to buffer against chronic stress and ameliorate age-related decline. Here we review experimental evidence both for and against this proposal, as well as the implications that isoform-specific sirtuin activation may have for healthy aging in humans.
C1 Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02215 USA.
   Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA USA.
C3 Harvard University; Harvard University Medical Affiliates; Dana-Farber
   Cancer Institute; Harvard University; Harvard Medical School
RP Puigserver, P (corresponding author), Dana Farber Canc Inst, 450 Brookline Ave,CLSB 11144, Boston, MA 02215 USA.
EM pere_puigserver@dfci.harvard.edu
FU American Heart Association predoctoral fellowship; NIH National Research
   Service Award Kirschstein fellowship; Ewha Womans University;
   Dana-Farber Cancer Institute; American Diabetes Association; Department
   of Defense; NIH/NIDDK [RO1069966]
FX J.A. Hall is supported by an American Heart Association predoctoral
   fellowship. J.E. Dominy is supported in part by an NIH National Research
   Service Award Kirschstein fellowship. Y. Lee is funded by a scholarship
   from Ewha Womans University. P. Puigserver has received support from the
   Dana-Farber Cancer Institute, American Diabetes Association, Department
   of Defense, and NIH/NIDDK (grant RO1069966).
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NR 124
TC 186
Z9 195
U1 2
U2 50
PU AMER SOC CLINICAL INVESTIGATION INC
PI ANN ARBOR
PA 2015 MANCHESTER RD, ANN ARBOR, MI 48104 USA
SN 0021-9738
EI 1558-8238
J9 J CLIN INVEST
JI J. Clin. Invest.
PD MAR
PY 2013
VL 123
IS 3
BP 973
EP 979
DI 10.1172/JCI64094
PG 7
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 101BE
UT WOS:000315749400008
PM 23454760
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Simcox, JA
   McClain, DA
AF Simcox, Judith A.
   McClain, Donald A.
TI Iron and Diabetes Risk
SO CELL METABOLISM
LA English
DT Review
ID INSULIN SECRETORY CAPACITY; HEPATIC GLUCOSE-PRODUCTION; INDUCED
   OXIDATIVE STRESS; DRUG TARGET MITONEET; BETA-CELL FUNCTION; SERUM
   FERRITIN; METABOLIC SYNDROME; LIPID-METABOLISM; BLOOD-PRESSURE;
   ADIPOSE-TISSUE
AB Iron overload is a risk factor for diabetes. The link between iron and diabetes was first recognized in pathologic conditions-hereditary hemochromatosis and thalassemia-but high levels of dietary iron also impart diabetes risk. Iron plays a direct and causal role in diabetes pathogenesis mediated both by beta cell failure and insulin resistance. Iron also regulates metabolism in most tissues involved in fuel homeostasis, with the adipocyte in particular serving an iron-sensing role. The underlying molecular mechanisms mediating these effects are numerous and incompletely understood but include oxidant stress and modulation of adipokines and intracellular signal transduction pathways.
C1 [Simcox, Judith A.; McClain, Donald A.] Univ Utah, Sch Med, Dept Med, Salt Lake City, UT 84132 USA.
   [Simcox, Judith A.; McClain, Donald A.] Univ Utah, Sch Med, Dept Biochem, Salt Lake City, UT 84132 USA.
   [McClain, Donald A.] VA Med Ctr, Res Serv, Salt Lake City, UT 84132 USA.
C3 Utah System of Higher Education; University of Utah; Utah System of
   Higher Education; University of Utah
RP McClain, DA (corresponding author), Univ Utah, Sch Med, Dept Med, Salt Lake City, UT 84132 USA.
EM donald.mcclain@hsc.utah.edu
OI Simcox, Judith/0000-0001-7350-6342; McClain, Don/0000-0002-3310-2359
FU NIH [DK081842, T32DK091317]; Research Service of the Veterans
   Administration; Marilyn Jane Robinson Foundation
FX This work was supported by the NIH (DK081842 to D. M. and T32DK091317 to
   J.S.), the Research Service of the Veterans Administration, and the
   Marilyn Jane Robinson Foundation. The authors would like to acknowledge
   the assistance of Amnon Schlegel for assistance in reviewing the
   manuscript.
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NR 161
TC 403
Z9 440
U1 2
U2 51
PU CELL PRESS
PI CAMBRIDGE
PA 50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA
SN 1550-4131
EI 1932-7420
J9 CELL METAB
JI Cell Metab.
PD MAR 5
PY 2013
VL 17
IS 3
BP 329
EP 341
DI 10.1016/j.cmet.2013.02.007
PG 13
WC Cell Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Endocrinology & Metabolism
GA 242TP
UT WOS:000326265400006
PM 23473030
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Tabas, I
   Tall, A
   Accili, D
AF Tabas, Ira
   Tall, Alan
   Accili, Domenico
TI The Impact of Macrophage Insulin Resistance on Advanced Atherosclerotic
   Plaque Progression
SO CIRCULATION RESEARCH
LA English
DT Review
DE atherosclerosis; insulin resistance; diabetes; macrophages; apoptosis
ID ENDOPLASMIC-RETICULUM STRESS; CARDIOVASCULAR RISK-FACTORS; UNFOLDED
   PROTEIN RESPONSE; FOAM CELL-FORMATION; APOPTOTIC CELLS;
   DIABETES-MELLITUS; NECROTIC CORE; FATTY-ACIDS; LIPID CORE; CHOLESTEROL
AB Atherothrombotic vascular disease is the major cause of death and disability in obese and diabetic subjects with insulin resistance. Although increased systemic risk factors in the setting of insulin resistance contribute to this problem, it is likely exacerbated by direct effects of insulin resistance on the arterial wall cells that participate in atherosclerosis. A critical process in the progression of subclinical atherosclerotic lesions to clinically relevant lesions is necrotic breakdown of plaques. Plaque necrosis, which is particularly prominent in the lesions of diabetics, is caused by the combination of macrophage apoptosis and defective phagocytic clearance, or efferocytosis, of the apoptotic macrophages. One cause of macrophage apoptosis in advanced plaques is activation of a proapoptotic branch of the unfolded protein response, which is an endoplasmic reticulum stress pathway. Macrophages have a functional insulin receptor signaling pathway, and downregulation of this pathway in the setting insulin resistance enhances unfolded protein response-induced apoptosis. Moreover, other aspects of the obesity/insulin-resistance syndrome may adversely affect efferocytosis. These processes may therefore provide an important mechanistic link among insulin resistance, plaque necrosis, and atherothrombotic vascular disease and suggest novel therapeutic approaches to this expanding health problem. (Circ Res. 2010;106:58-67.)
C1 [Tabas, Ira; Tall, Alan; Accili, Domenico] Columbia Univ, Dept Med, New York, NY 10032 USA.
   [Tabas, Ira; Tall, Alan] Columbia Univ, Dept Physiol & Cellular Biophys, New York, NY 10032 USA.
   [Tabas, Ira] Columbia Univ, Dept Pathol & Cell Biol, New York, NY 10032 USA.
C3 Columbia University; Columbia University; Columbia University
RP Tabas, I (corresponding author), Columbia Univ, Dept Med, 630 W 168th St, New York, NY 10032 USA.
EM iat1@columbia.edu
RI Tall, Alan/AAT-8528-2021; Stefanadis, Christodoulos/ABH-2232-2020
OI Stefanadis, Christodoulos/0000-0001-5974-6454; Tabas,
   Ira/0000-0003-3429-1515
FU NIH [HL087123, HL075662, HL054591]; US Army Medical Research and
   Materiel Command (USAMRMC) [W81XWH-06-1-0212]
FX This work was supported by NIH grants HL087123, HL075662, and HL054591
   and US Army Medical Research and Materiel Command (USAMRMC) grant
   W81XWH-06-1-0212.
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NR 107
TC 96
Z9 104
U1 0
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0009-7330
EI 1524-4571
J9 CIRC RES
JI Circ.Res.
PD JAN 8
PY 2010
VL 106
IS 1
BP 58
EP 67
DI 10.1161/CIRCRESAHA.109.208488
PG 10
WC Cardiac & Cardiovascular Systems; Hematology; Peripheral Vascular
   Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Hematology
GA 541GP
UT WOS:000273403600013
PM 20056946
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Singh, MK
   Leslie, SM
   Packer, MM
   Zaiko, YV
   Phillips, OR
   Weisman, EF
   Wall, DM
   Jo, B
   Rasgon, N
AF Singh, Manpreet K.
   Leslie, Sara M.
   Packer, Mary Melissa
   Zaiko, Yevgeniya V.
   Phillips, Owen R.
   Weisman, Elizabeth F.
   Wall, Danielle M.
   Jo, Booil
   Rasgon, Natalie
TI Brain and behavioral correlates of insulin resistance in youth with
   depression and obesity
SO HORMONES AND BEHAVIOR
LA English
DT Article
DE Pediatric depression; Obesity; Insulin resistance; Resting state
   functional connectivity; Neural structure
ID STATE FUNCTIONAL CONNECTIVITY; 3-FACTOR EATING QUESTIONNAIRE; METABOLIC
   SYNDROME; CONSTRUCT-VALIDITY; PHYSICAL-ACTIVITY; MAJOR DEPRESSION;
   CEREBRAL-CORTEX; GRAY-MATTER; REWARD; ADOLESCENTS
AB Depression, together with insulin resistance, is increasingly prevalent among youth. These conditions have traditionally been compartmentalized, but recent evidence suggests that a shared brain motivational network underlies their co-occurrence. We posit that, in the context of depressive symptoms, insulin resistance is associated with aberrant structure and functional connectivity in the Anterior Cingulate Cortex (ACC) and hippocampus. This motivational neural circuit underlies dysfunctional behavioral responses and increased sensitivity to rewarding aspects of ingesting high calorie food that lead to disinhibition of eating even when satiated. To investigate this shared mechanism, we evaluated a sample of forty-two depressed and overweight (BMI > 85th %) youth aged 9 to 17. Using ACC and hippocampus structural and seed-based regions of interest, we investigated associations between insulin resistance, depression, structure (ACC thickness, and ACC and hippocampal area), and resting-state functional connectivity (RSFC). We predicted that aberrant associations among these neural and behavioral characteristics would be stronger in insulin resistant compared to insulin sensitive youth. We found that youth with greater insulin resistance had higher levels of anhedonia and more food seeking behaviors, reduced hippocampal and ACC volumes, and greater levels of ACC and hippocampal dysconnectivity to fronto-limbic reward networks at rest. For youth with high levels of insulin resistance, thinner ACC and smaller hippocampal volumes were associated with more severe depressive symptoms, whereas the opposite was true for youth with low levels of insulin resistance. The ACC-hippocampal motivational network that subserves depression and insulin resistance separately, may represent a critical neural interaction that link these syndromes together.
C1 [Singh, Manpreet K.; Leslie, Sara M.; Packer, Mary Melissa; Zaiko, Yevgeniya V.; Phillips, Owen R.; Weisman, Elizabeth F.; Wall, Danielle M.; Jo, Booil; Rasgon, Natalie] Stanford Univ, Sch Med, Dept Psychiat & Behav Sci, Stanford, CA 94305 USA.
C3 Stanford University
RP Singh, MK (corresponding author), Stanford Univ, Dept Psychiat & Behav Sci, Stanford, CA 94305 USA.
EM mksingh@stanford.edu
RI Rasgon, Natalie/ABH-9813-2020; phillips, owen/J-3651-2017; Singh,
   Manpreet/L-1068-2014
OI Leslie, Sara/0000-0002-5557-4293; Singh, Manpreet/0000-0002-4373-3293;
   Packer West, Melissa/0000-0001-7161-5860
FU National Institute of Mental Health [R01MH106581]
FX This work was supported by the National Institute of Mental Health
   (R01MH106581). We would like to express appreciation to our research
   participants and families and members of our Pediatric Emotion And
   Resilience Lab (PEARL) for their contributions to this work.
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NR 118
TC 50
Z9 51
U1 1
U2 29
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0018-506X
EI 1095-6867
J9 HORM BEHAV
JI Horm. Behav.
PD FEB
PY 2019
VL 108
BP 73
EP 83
DI 10.1016/j.yhbeh.2018.03.009
PG 11
WC Behavioral Sciences; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Behavioral Sciences; Endocrinology & Metabolism
GA HN4YH
UT WOS:000460189100008
PM 29596854
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Khassawneh, AH
   Alzoubi, A
   Khasawneh, AG
   Abdo, N
   Abu-Naser, D
   Al-Mistarehi, AH
   Albattah, MF
   Kheirallah, KA
AF Khassawneh, Adi H.
   Alzoubi, Abdallah
   Khasawneh, Aws G.
   Abdo, Nour
   Abu-Naser, Dania
   Al-Mistarehi, Abdel-Hameed
   Albattah, Malak F.
   Kheirallah, Khalid A.
TI The relationship between depression and metabolic control parameters in
   type 2 diabetic patients: A cross-sectional and feasibility
   interventional study
SO INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
LA English
DT Article
ID COMORBID DEPRESSION; AFRICAN-AMERICANS; PREVALENCE; HEALTH; SYMPTOMS;
   MELLITUS; ADULTS; METAANALYSIS; INDIVIDUALS; RISK
AB Background Substantial evidence supports a bidirectional relationship between diabetes and clinical depression. However, little is known about the effect of treating one condition on the control of the other. Thus, this study aimed to determine the prevalence of depression among Type II diabetes mellitus (T2DM) patients and to assess the efficacy and feasibility of escitalopram treatment of depression on their metabolic control parameters.
   Methods T2DM patients attending primary care clinics in the North of Jordan were enrolled in a cross-sectional study during the period from February to December 2019 (n = 157). Depressive symptoms were screened utilising the patient health questionnaire-9 (PHQ-9) tool. Metabolic control was assessed by measurement of glycated haemoglobin (HbA1c), triglycerides, cholesterol, low-density lipoprotein (LDL) and high-density lipoprotein (HDL). Patients with moderate to severe depressive symptoms by PHQ-9 (n = 58) were interviewed by a psychiatrist to confirm a clinical diagnosis of depression. Eligible depressed patients were administered escitalopram 10 mg orally once daily for 3 months (n = 12). Thereafter, depressive symptoms and metabolic control measures were reassessed.
   Results The prevalence of moderate to severe depressive symptoms among T2DM patients, according to PHQ-9, was 36.94%, while the prevalence of clinical depression based on interview was 7.64%. Baseline PHQ-9 scores correlated significantly with baseline levels of HbA1c, HDL, cholesterol and triglycerides. Escitalopram treatment intervention resulted in significant improvement of PHQ-9 scores without significantly improving any of the metabolic control measures.
   Conclusion The relationship between depression and T2DM in the context of metabolic syndrome is plausible. However, our results show that escitalopram treatment may not be associated with significant improvement in metabolic control parameters among these patients. Our study has laid the groundwork for future randomised clinical trials with larger sample size and longer follow-up.
C1 [Khassawneh, Adi H.; Abdo, Nour; Al-Mistarehi, Abdel-Hameed; Kheirallah, Khalid A.] Jordan Univ Sci & Technol, Dept Publ Hlth & Family Med, Fac Med, POB 3030, Irbid 22110, Jordan.
   [Alzoubi, Abdallah] Jordan Univ Sci & Technol, Dept Pharmacol, Fac Med, Irbid, Jordan.
   [Alzoubi, Abdallah] Ajman Univ, Coll Med, Ajman, U Arab Emirates.
   [Khasawneh, Aws G.; Albattah, Malak F.] Jordan Univ Sci & Technol, Dept Neurosci, Fac Med, Irbid, Jordan.
   [Abu-Naser, Dania] Al Balqa Appl Univ, Irbid Univ Coll, Dept Appl Sci, Irbid, Jordan.
C3 Jordan University of Science & Technology; Jordan University of Science
   & Technology; Ajman University; Jordan University of Science &
   Technology; Al-Balqa Applied University
RP Khassawneh, AH; Al-Mistarehi, AH (corresponding author), Jordan Univ Sci & Technol, Dept Publ Hlth & Family Med, Fac Med, POB 3030, Irbid 22110, Jordan.
EM ohkhasawneh@just.edu.jo; awalmistarehi18@med.just.edu.jo
RI Kheirallah, Khalid/HJH-7391-2023; Alzoubi, Abdallah/LFU-9102-2024;
   Al-Mistarehi, Abdel-Hameed/ABA-1722-2020; Alrawashdeh, Ahmad/N-3562-2017
OI Khassawneh, Adi/0000-0002-3245-8847; Abu-Naser,
   Dania/0000-0002-8817-4990; Kheirallah, Khalid/0000-0003-4504-4472;
   Al-Mistarehi, Abdel-Hameed/0000-0003-4713-8536; Alrawashdeh,
   Ahmad/0000-0003-2458-8200; Alzoubi, Abdallah/0000-0002-0467-8420
FU Deanship of Research at Jordan University of Science and Technology
   [232/2015]
FX This study was funded by the Deanship of Research at Jordan University
   of Science and Technology (grant #232/2015)
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NR 68
TC 8
Z9 8
U1 0
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1368-5031
EI 1742-1241
J9 INT J CLIN PRACT
JI Int. J. Clin. Pract.
PD APR
PY 2021
VL 75
IS 4
AR e13777
DI 10.1111/ijcp.13777
EA NOV 2020
PG 11
WC Medicine, General & Internal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine; Pharmacology & Pharmacy
GA RC8GK
UT WOS:000588832300001
PM 33098211
OA gold
DA 2025-06-11
ER

PT J
AU Eggers, AE
AF Eggers, Arnold E.
TI Redrawing Papez' circuit: A theory about how acute stress becomes
   chronic and causes disease
SO MEDICAL HYPOTHESES
LA English
DT Article
ID CORTEX LAYER-II; HIPPOCAMPAL-FORMATION; CUSHINGS-SYNDROME; NEURONS;
   STROKE; IDENTIFICATION; NEUROGENESIS; HYPERTENSION; DEPRESSION; MIGRAINE
AB The diseases of chronic stress include migraine, essential hypertension, depression, and the metabolic syndrome. A theory is presented to explain how acute stress becomes chronic and causes these inter-related conditions. The theory is based on a new "circuit of emotion", which is derived from Papez' famous theory of emotion. The hypothesis is as follows: There is a basic circuit of emotion which runs from the hippocampus (defined as the dentate gyrus plus the CA regions), where emotion arises, to the amygdala and from there to serotonergic pacemaker cells in the dorsal raphe nucleus (DRN). The DRN projects back to the dentate gyrus in two ways: a direct route without a stop and an indirect route via pacemaker cells in the entorhinat cortex. The purpose of the direct route is to promote neurogenesis in the subgranular zone of the dentate; the indirect route has two purposes: to imprint ongoing moments of consciousness onto new dentate cells for retention as memory and to provide a negative feedback loop for regulation of the whole process. The hippocampus, the amygdala, and the DRN all project to the hypothalamus, which are branches off the basic Loop that subserve the autonomic expression of emotion.
   Pathologic overdrive of the DRN causes overdrive of the entorhinal cortex, which leads to excitotoxic cell death of neurons in the hippocampus involved in the negative feedback loop. The disinhibited amygdala and DRN are then free to orchestrate the syndromes of chronic stress. Recovery from chronic stress requires repopulation of the dentate gyrus and restoration of the feedback loop. Excitotoxic cell death in the hippocampus results from either extraordinary acute stress or increased susceptibility to DRN overdrive, as might be caused, for example, by genetic factors, age, high cortisol levels, or incomplete recovery from previous damage.
   Three goals for therapeutic intervention are identified: inhibition of pacemaker cells in the DRN (which can be targeted by ethosuximide and other drugs that block serotonergic pacemaker currents), inhibition of pacemaker cells in the entorhinal cortex (which can be targeted by anti-epileptic drugs that block pacemaker currents in the entorhinat cortex, e.g. phenytoin), and restoration of serotonin levels in the dentate gyrus (which can be accomplished with antidepressants). It is logical to use drugs from all three categories, either atone on in combination, to treat any of the four diseases of chronic stress. This leads to novel therapeutic recommendations, e.g. the use of ethosuximide, mood-stabilizers, and anti-depressants in synergy to treat essential hypertension. (c) 2007 Elsevier Ltd. All rights reserved.
C1 Suny Downstate Med Ctr, Dept Neurol, Brooklyn, NY 11203 USA.
C3 State University of New York (SUNY) System; SUNY Downstate Health
   Sciences University
RP Eggers, AE (corresponding author), Suny Downstate Med Ctr, Dept Neurol, 450 Clarkson Ave,Box 1213, Brooklyn, NY 11203 USA.
EM eggersa@aol.com
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NR 23
TC 32
Z9 41
U1 0
U2 14
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0306-9877
J9 MED HYPOTHESES
JI Med. Hypotheses
PY 2007
VL 69
IS 4
BP 852
EP 857
DI 10.1016/j.mehy.2007.01.074
PG 6
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 210TH
UT WOS:000249478000025
PM 17376605
DA 2025-06-11
ER

PT J
AU Kemp, DE
AF Kemp, David E.
TI Managing the side effects associated with commonly used treatments for
   bipolar depression
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Review
DE Bipolar disorder; Depression; Pharmacotherapy; Side effects
ID OLANZAPINE-FLUOXETINE COMBINATION; CARDIOVASCULAR RISK-FACTORS;
   OPEN-LABEL EXTENSION; DOUBLE-BLIND; METABOLIC SYNDROME; I-DISORDER;
   MAINTENANCE TREATMENT; ATYPICAL ANTIPSYCHOTICS; MOOD STABILIZER;
   WEIGHT-GAIN
AB Background: The most commonly used pharmacologic therapies for bipolar depression are mood stabilizers, atypical antipsychotics, and antidepressants. This paper reviews common side effects associated with these medications and provides recommendations for managing adverse medication effects in clinical practice.
   Methods: Narrative review based on literature searches of Medline and evidence-based treatment guidelines for agents that have been approved by the US Food and Drug Administration and/or are commonly used to treat bipolar depression.
   Results: Side effects of bipolar depression pharmacotherapies are common and vary by medication, with weight gain, metabolic dysregulation, sedation/somnolence, and akathisia among those observed most frequently. These adverse events (weight gain and sedation/somnolence, in particular) negatively affect treatment adherence in patients with bipolar disorder. Furthermore, endocrine and metabolic comorbidities, weight gain, and obesity may reduce the likelihood of positive clinical responses to pharmacologic therapies. Clinicians may consider switching patients to bipolar depression medication(s) with a lower propensity for sedation or adverse metabolic effects. Lifestyle modification (e.g., dietary changes, exercise) is an important component in the treatment of weight gain/obesity, dyslipidemia, hypertension, and hyperglycemia; in addition, a wide range of medications are available as therapeutic options for patients in whom non-pharmacologic management strategies are insufficient. The use of adjunctive medication may also reduce treatment-related sedation and somnolence.
   Limitations: The selection of relevant studies from the literature search relied primarily on the author's expertise in the area of bipolar depression and knowledge of the issues addressed.
   Conclusions: Successful treatment of bipolar depression extends beyond managing mood symptoms to also monitoring adverse medication events and managing associated medical disorders. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Kemp, David E.] Case Western Reserve Univ, Univ Hosp Case Med Ctr, Dept Psychiat, Cleveland, OH 44106 USA.
C3 University System of Ohio; Case Western Reserve University; Case Western
   Reserve University Hospital
RP Kemp, DE (corresponding author), Case Western Reserve Univ, 10524 Euclid Ave,12th Floor, Cleveland, OH 44106 USA.
EM kemp.david@gmail.com
FU Teva Pharmaceuticals, North Wales, PA; Sunovion Pharmaceuticals,
   Marlborough, MA
FX Funding for technical editorial and medical writing support was provided
   by Teva Pharmaceuticals, North Wales, PA. Publication of the manuscript
   was supported by an independent medical education grant from Sunovion
   Pharmaceuticals, Marlborough, MA.
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NR 127
TC 50
Z9 53
U1 0
U2 19
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD DEC
PY 2014
VL 169
SU 1
BP S34
EP S44
DI 10.1016/S0165-0327(14)70007-2
PG 11
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA CP6OT
UT WOS:000360007700006
PM 25533913
OA hybrid
DA 2025-06-11
ER

PT J
AU Valentine, RJ
   McAuley, E
   Vieira, VJ
   Baynard, T
   Hu, L
   Evans, EM
   Woods, JA
AF Valentine, Rudy J.
   McAuley, Edward
   Vieira, Victoria J.
   Baynard, Tracy
   Hu, Liang
   Evans, Ellen M.
   Woods, Jeffrey A.
TI Sex differences in the relationship between obesity, C-reactive protein,
   physical activity, depression, sleep quality and fatigue in older adults
SO BRAIN BEHAVIOR AND IMMUNITY
LA English
DT Article
DE Fatigue; Adiposity; Inflammation; Sex differences; Depression; Fitness;
   Physical activity
ID EXCESSIVE DAYTIME SLEEPINESS; BODY-MASS INDEX; REPORTED FUNCTIONAL
   LIMITATION; SELF-PERCEIVED FATIGUE; INSULIN-RESISTANCE; FAT MASS;
   CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; ADIPOSE-TISSUE;
   UNITED-STATES
AB Fatigue is a serious health concern in the elderly. Sex differences exist in adiposity, systemic inflammation, physical activity/fitness and fatigue; however, the relations among these variables remain inadequately characterized impeding the development of fatigue prevention strategies. Measures of adiposity, C-reactive protein, physical activity, aerobic fitness, fatigue, sleep quality and depression were obtained from 127 community-dwelling older adults. Although similar in age (70 y) and BMI (28.0 kg/m(2)) women (n = 80) reported 63% greater fatigue than men (p = 0.04). Adiposity (r = 0.44), CRP (r = 0.29), physical activity (r = -0.26) and fitness (r = -0.41) were related to fatigue in women (all p < 0.05), but not in men. Depression was also related to fatigue in women (r = 0.37), and was the only variable related to fatigue in men (r = 0.42). In women, fatigue was independently explained (all p < 0.05) by CRP (6.6%), depression (6.3%), physical activity (5.8%), and adiposity (3.9%); however, in men, only depression explained variance in fatigue (12.0%). CRP was 40% higher and adiposity 12% higher in women reporting fatigue compared to those with no fatigue; no such differences existed in men. Obese women perceived a greater degree of fatigue than non-obese women, but this was not the case in men. Women report more fatigue than men which was independently associated with inflammation, depression, physical activity and adiposity, whereas in men the only independent predictor was depression. Strategies to prevent fatigue may differ in older women and men, especially with regard to inflammation, physical activity and adiposity. (C) 2008 Elsevier Inc. All rights reserved.
C1 [Valentine, Rudy J.; McAuley, Edward; Baynard, Tracy; Evans, Ellen M.; Woods, Jeffrey A.] Univ Illinois, Dept Kinesiol & Community Hlth, Urbana, IL 61801 USA.
   [Vieira, Victoria J.; Evans, Ellen M.; Woods, Jeffrey A.] Univ Illinois, Div Nutr Sci, Urbana, IL 61801 USA.
   [Vieira, Victoria J.; Woods, Jeffrey A.] Univ Illinois, Integrat Immunol & Behav Program, Urbana, IL 61801 USA.
   [Hu, Liang] Tianjin Univ Sport, Tianjin, Peoples R China.
C3 University of Illinois System; University of Illinois Urbana-Champaign;
   University of Illinois System; University of Illinois Urbana-Champaign;
   University of Illinois System; University of Illinois Urbana-Champaign;
   Tianjin University of Sport
RP Woods, JA (corresponding author), Univ Illinois, Dept Kinesiol & Community Hlth, 906 S Goodwin Ave, Urbana, IL 61801 USA.
EM woods1@illinois.edu
RI Baynard, Tracy/AAN-8711-2021; McAuley, Edward/A-9508-2008
OI Baynard, Tracy/0000-0002-5150-4095; Vieira-Potter,
   Victoria/0000-0001-7563-0806
FU NIA NIH HHS [R01 AG-18861] Funding Source: Medline
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NR 66
TC 62
Z9 78
U1 0
U2 30
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0889-1591
EI 1090-2139
J9 BRAIN BEHAV IMMUN
JI Brain Behav. Immun.
PD JUL
PY 2009
VL 23
IS 5
SI SI
BP 643
EP 648
DI 10.1016/j.bbi.2008.12.003
PG 6
WC Immunology; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Immunology; Neurosciences & Neurology; Psychiatry
GA 461NL
UT WOS:000267274000011
PM 19133324
DA 2025-06-11
ER

PT J
AU Fond, GB
   Lagier, JC
   Honore, S
   Lancon, C
   Korchia, T
   De Verville, PLS
   Llorca, PM
   Auquier, P
   Guedj, E
   Boyer, L
AF Fond, Guillaume B.
   Lagier, Jean-Christophe
   Honore, Stephane
   Lancon, Christophe
   Korchia, Theo
   De Verville, Pierre-Louis Sunhary
   Llorca, Pierre-Michel
   Auquier, Pascal
   Guedj, Eric
   Boyer, Laurent
TI Microbiota-Orientated Treatments for Major Depression and Schizophrenia
SO NUTRIENTS
LA English
DT Review
DE psychiatry; schizophrenia; depression; microbiota; transplantation
ID CLOSTRIDIUM-DIFFICILE INFECTION; IRRITABLE-BOWEL-SYNDROME; C-REACTIVE
   PROTEIN; QUALITY-OF-LIFE; FECAL MICROBIOTA; GUT MICROBIOTA;
   ULCERATIVE-COLITIS; METABOLIC SYNDROME; TRANSPLANTATION; SYMPTOMS
AB Background and significance. There is a need to develop new hypothesis-driven treatment for both both major depression (MD) and schizophrenia in which the risk of depression is 5 times higher than the general population. Major depression has been also associated with poor illness outcomes including pain, metabolic disturbances, and less adherence. Conventional antidepressants are partly effective, and 44% of the subjects remain unremitted under treatment. Improving MD treatment efficacy is thus needed to improve the SZ prognosis. Microbiota-orientated treatments are currently one of the most promising tracks. Method. This work is a systematic review synthetizing data of arguments to develop microbiota-orientated treatments (including fecal microbiota transplantation (FMT)) in major depression and schizophrenia. Results. The effectiveness of probiotic administration in MD constitutes a strong evidence for developing microbiota-orientated treatments. Probiotics have yielded medium-to-large significant effects on depressive symptoms, but it is still unclear if the effect is maintained following probiotic discontinuation. Several factors may limit MD improvement when using probiotics, including the small number of bacterial strains administered in probiotic complementary agents, as well as the presence of a disturbed gut microbiota that probably limits the probiotics' impact. FMT is a safe technique enabling to improve microbiota in several gut disorders. The benefit/risk ratio of FMT has been discussed and has been recently improved by capsule administration. Conclusion. Cleaning up the gut microbiota by transplanting a totally new human gut microbiota in one shot, which is referred to as FMT, is likely to strongly improve the efficacy of microbiota-orientated treatments in MD and schizophrenia and maintain the effect over time. This hypothesis should be tested in future clinical trials.
C1 [Fond, Guillaume B.; Honore, Stephane; Lancon, Christophe; Korchia, Theo; De Verville, Pierre-Louis Sunhary; Auquier, Pascal; Boyer, Laurent] Aix Marseille Univ, Hop Univ Marseille, CEReSS Hlth Serv Res & Qual Life Ctr, Dept Psychiatrie Univ,EA 3279, 27 Blvd Jean Moulin, F-13005 Marseille, France.
   [Lagier, Jean-Christophe] Aix Marseille Univ, Inst Hosp Univ Mediterranee Infect, AP HP, Inst Rech Dev Microbes Evolut Phylogeny & Infect, F-13005 Marseille, France.
   [Llorca, Pierre-Michel] CHU Clermont Ferrand, F-63000 Cllermont Ferrand, France.
   [Guedj, Eric] Aix Marseille Univ, Ecole Cent Marseille, Inst Fresnel, Dept Med Nucl,CERIMED,CNRS,UMR 7249, F-13005 Marseille, France.
C3 Aix-Marseille Universite; Assistance Publique-Hopitaux de Marseille;
   Assistance Publique Hopitaux Paris (APHP); Aix-Marseille Universite;
   Universite Clermont Auvergne (UCA); CHU Clermont Ferrand; Centre
   National de la Recherche Scientifique (CNRS); CNRS - Institute for
   Engineering & Systems Sciences (INSIS); Aix-Marseille Universite
RP Fond, GB (corresponding author), Aix Marseille Univ, Hop Univ Marseille, CEReSS Hlth Serv Res & Qual Life Ctr, Dept Psychiatrie Univ,EA 3279, 27 Blvd Jean Moulin, F-13005 Marseille, France.
EM guillaume.fond@gmail.com; JeanChristophe.LAGIER@ap-hm.fr;
   stephane.honore@ap-hm.fr; christophe.lancon@ap-hm.fr;
   theo.korchia@ap-hm.fr; deverville.pierrelouis@gmail.com;
   pmllorca@chu-clermontferrand.fr; pascal.auquier@univ-amu.fr;
   eric.guedj@ap-hm.fr; laurent.boyer@ap-hm.fr
RI Fond, Guillaume/D-7646-2011; Guedj, Eric/AAK-1589-2020; Boyer,
   Laurent/E-5728-2016; Lagier, Jean-Christophe/AAY-3837-2021
OI Boyer, Laurent/0000-0003-1229-6622; Lagier,
   Jean-Christophe/0000-0003-0771-8245; Korchia, Theo/0000-0002-6392-9322;
   Llorca, Pierre michel/0000-0001-7438-8990
FU Hopitaux Universitaires de Marseille (HUM) [AORC-2018]
FX This work was funded by Hopitaux Universitaires de Marseille (HUM),
   grant number AORC-2018.
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NR 68
TC 40
Z9 43
U1 3
U2 52
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD APR
PY 2020
VL 12
IS 4
AR 1024
DI 10.3390/nu12041024
PG 15
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nutrition & Dietetics
GA LL8VE
UT WOS:000531831300144
PM 32276499
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Psaltopoulou, T
   Sergentanis, TN
   Panagiotakos, DB
   Sergentanis, IN
   Kosti, R
   Scarmeas, N
AF Psaltopoulou, Theodora
   Sergentanis, Theodoros N.
   Panagiotakos, Demosthenes B.
   Sergentanis, Ioannis N.
   Kosti, Rena
   Scarmeas, Nikolaos
TI Mediterranean Diet, Stroke, Cognitive Impairment, and Depression: A
   Meta-Analysis
SO ANNALS OF NEUROLOGY
LA English
DT Article
ID CARDIOVASCULAR-DISEASE RISK; PHYSICAL-ACTIVITY; MYOCARDIAL-INFARCTION;
   ALZHEIMERS-DISEASE; METABOLIC SYNDROME; STYLE DIET; ADHERENCE;
   INFLAMMATION; PATTERNS; SYMPTOMS
AB ObjectiveThis meta-analysis aims to quantitatively synthesize all studies that examine the association between adherence to a Mediterranean diet and risk of stroke, depression, cognitive impairment, and Parkinson disease.
   MethodsPotentially eligible publications were those providing effect estimates of relative risk (RR) for the association between Mediterranean diet and the aforementioned outcomes. Studies were sought in PubMed up to October 31, 2012. Maximally adjusted effect estimates were extracted; separate analyses were performed for high and moderate adherence.
   ResultsTwenty-two eligible studies were included (11 covered stroke, 9 covered depression, and 8 covered cognitive impairment; only 1 pertained to Parkinson's disease). High adherence to Mediterranean diet was consistently associated with reduced risk for stroke (RR=0.71, 95% confidence interval [CI]=0.57-0.89), depression (RR=0.68, 95% CI=0.54-0.86), and cognitive impairment (RR=0.60, 95% CI=0.43-0.83). Moderate adherence was similarly associated with reduced risk for depression and cognitive impairment, whereas the protective trend concerning stroke was only marginal. Subgroup analyses highlighted the protective actions of high adherence in terms of reduced risk for ischemic stroke, mild cognitive impairment, dementia, and particularly Alzheimer disease. Meta-regression analysis indicated that the protective effects of Mediterranean diet in stroke prevention seemed more sizeable among males. Concerning depression, the protective effects of high adherence seemed independent of age, whereas the favorable actions of moderate adherence seemed to fade away with more advanced age.
   InterpretationAdherence to a Mediterranean diet may contribute to the prevention of a series of brain diseases; this may be of special value given the aging of Western societies. Ann Neurol 2013;74:580-591
C1 [Psaltopoulou, Theodora; Sergentanis, Theodoros N.; Sergentanis, Ioannis N.; Kosti, Rena] Univ Athens, Sch Med, Dept Hyg Epidemiol & Med Stat, GR-11527 Athens, Greece.
   [Panagiotakos, Demosthenes B.] Harokopio Univ, Dept Nutr & Dietet, Athens, Greece.
   [Sergentanis, Ioannis N.] Univ Hosp Geneva, Hosp Psychiat, Geneva, Switzerland.
   [Scarmeas, Nikolaos] Univ Athens, Sch Med, Dept Neurol, GR-11527 Athens, Greece.
   [Scarmeas, Nikolaos] Columbia Univ, Dept Neurol, New York, NY USA.
C3 National & Kapodistrian University of Athens; Athens Medical School;
   Harokopio University Athens; University of Geneva; Athens Medical
   School; National & Kapodistrian University of Athens; Columbia
   University
RP Psaltopoulou, T (corresponding author), Univ Athens, Sch Med, Dept Hyg Epidemiol & Med Stat, 75 M Asias Str, GR-11527 Athens, Greece.
EM tpsaltop@med.uoa.gr
RI Psaltopoulou, Theodora/AAA-6878-2020; Scarmeas, Nikolaos/AAD-2512-2020;
   Sergentanis, Theodoros/AAD-8303-2019; Panagiotakos,
   Demosthenes/K-8294-2019
OI Sergentanis, Theodoros N./0000-0002-9355-5528; Psaltopoulou,
   Theodora/0000-0002-1404-9716; Kosti, Rena/0000-0001-7915-6064
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NR 62
TC 593
Z9 643
U1 5
U2 161
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0364-5134
EI 1531-8249
J9 ANN NEUROL
JI Ann. Neurol.
PD OCT
PY 2013
VL 74
IS 4
BP 580
EP 591
DI 10.1002/ana.23944
PG 12
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 257FN
UT WOS:000327369100012
PM 23720230
DA 2025-06-11
ER

PT J
AU Iozzo, P
   Holmes, M
   Schmidt, MV
   Cirulli, F
   Guzzardi, MA
   Berry, A
   Balsevich, G
   Andreassi, MG
   Wesselink, JJ
   Liistro, T
   Gómez-Puertas, P
   Eriksson, JG
   Seckl, J
AF Iozzo, Patricia
   Holmes, Megan
   Schmidt, Mathias V.
   Cirulli, Francesca
   Guzzardi, Maria Angela
   Berry, Alessandra
   Balsevich, Georgia
   Andreassi, Maria Grazia
   Wesselink, Jan-Jaap
   Liistro, Tiziana
   Gomez-Puertas, Paulino
   Eriksson, Johan G.
   Seckl, Jonathan
TI Developmental ORIgins of Healthy and Unhealthy AgeiNg: The Role of
   Maternal Obesity - Introduction to DORIAN
SO OBESITY FACTS
LA English
DT Article
DE Pregnancy; Foetal programming; Obesity; Diabetes; Cardiovascular
   disease; Stress; Oxidative damage; Insulin resistance; HSD2; p66
ID HIGH-FAT DIET; ANXIETY-LIKE BEHAVIOR; TYPE-2 11-BETA-HYDROXYSTEROID
   DEHYDROGENASE; BETA-HYDROXYSTEROID DEHYDROGENASE; PRENATAL DEXAMETHASONE
   EXPOSURE; PITUITARY-ADRENAL-AXIS; LOW-CARBOHYDRATE DIET; METABOLIC
   SYNDROME; INSULIN-RESISTANCE; TELOMERE LENGTH
AB Europe has the highest proportion of elderly people in the world. Cardiovascular disease, type 2 diabetes, sarcopenia and cognitive decline frequently coexist in the same aged individual, sharing common early risk factors and being mutually reinforcing. Among conditions which may contribute to establish early risk factors, this review focuses on maternal obesity, since the epidemic of obesity involves an ever growing number of women of reproductive age and children, calling for appropriate studies to understand the consequences of maternal obesity on the offspring's health and for developing effective measures and policies to improve people's health before their conception and birth. Though the current knowledge suggests that the long-term impact of maternal obesity on the offspring's health may be substantial, the outcomes of maternal obesity over the lifespan have not been quantified, and the molecular changes induced by maternal obesity remain poorly characterized. We hypothesize that maternal insulin resistance and reduced placental glucocorticoid catabolism, leading to oxidative stress, may damage the DNA, either in its structure (telomere shortening) or in its function (via epigenetic changes), resulting in altered gene expression/repair, disease during life, and pathological ageing. This review illustrates the background to the EU-FP7-HEALTH-DORIAN project. (C) 2014 S. Karger GmbH, Freiburg
C1 [Iozzo, Patricia; Guzzardi, Maria Angela; Andreassi, Maria Grazia; Liistro, Tiziana] CNR, Inst Clin Physiol, I-56124 Pisa, Italy.
   [Cirulli, Francesca; Berry, Alessandra] Ist Super Sanita, I-00161 Rome, Italy.
   [Holmes, Megan; Seckl, Jonathan] Univ Edinburgh, Ctr Cardiovasc Sci, Endocrinol Unit, Edinburgh, Midlothian, Scotland.
   [Schmidt, Mathias V.; Balsevich, Georgia] Max Planck Inst Psychiat MPG, Munich, Germany.
   [Wesselink, Jan-Jaap; Gomez-Puertas, Paulino] Biomol Informat SL, Madrid, Spain.
   [Eriksson, Johan G.] Samfundet Folkhalsan Svenska Finland Rf Folkhalsa, Helsinki, Finland.
   [Eriksson, Johan G.] Univ Helsinki, Dept Gen Practice & Primary Hlth Care, Helsinki, Finland.
C3 Consiglio Nazionale delle Ricerche (CNR); Istituto di Fisiologia Clinica
   (IFC-CNR); Istituto Superiore di Sanita (ISS); University of Edinburgh;
   Samfundet Folkhalsan; University of Helsinki
RP Iozzo, P (corresponding author), CNR, Inst Clin Physiol, Via Moruzzi 1, I-56124 Pisa, Italy.
EM patricia.iozzo@ifc.cnr.it
RI Cirulli, Francesca/H-5992-2019; Berry, Alessandra/N-9280-2017; Gibbs, J.
   Raphael/A-3984-2010; Gomez-Puertas, Paulino/G-8821-2014; Iozzo,
   Patricia/O-2893-2015; GUZZARDI, MARIAANGELA/K-1389-2016
OI Balsevich, Georgia/0000-0002-7839-018X; Berry,
   Alessandra/0000-0001-6562-9043; Eriksson, Johan/0000-0002-2516-2060;
   Andreassi, Maria Grazia/0000-0002-2163-0816; Schmidt,
   Mathias/0000-0002-3788-2268; CIRULLI, Francesca/0000-0001-9440-1873;
   Gomez-Puertas, Paulino/0000-0003-3131-729X; Iozzo,
   Patricia/0000-0001-6443-7074; GUZZARDI, MARIAANGELA/0000-0001-9574-5088
FU EU (FP7); Italian Ministry of Health (Italia-Usa Project) [11US/14/1];
   European Foundation for the Study of Diabetes (EFSD) [2009];  [278603]
FX Funding for the project is provided by EU (FP7) Project 'Developmental
   Origin of Healthy and Unhealthy Ageing: the Role of Maternal Obesity'
   (DORIAN) (grant n. 278603). Additional support was received by the
   Italian Ministry of Health (Italia-Usa Project), Fasc. 11US/14/1 (to
   FC), and the European Foundation for the Study of Diabetes (EFSD/Roche
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NR 200
TC 23
Z9 25
U1 0
U2 32
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1662-4025
EI 1662-4033
J9 OBESITY FACTS
JI Obes. Facts
PD APR
PY 2014
VL 7
IS 2
BP 130
EP 151
DI 10.1159/000362656
PG 22
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA AH2NF
UT WOS:000335957500007
PM 24801105
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Parto, P
   Lavie, CJ
AF Parto, Parham
   Lavie, Carl J.
TI Obesity and Cardiovascular Diseases
SO CURRENT PROBLEMS IN CARDIOLOGY
LA English
DT Review
ID BODY-MASS INDEX; CORONARY-ARTERY-DISEASE; ALL-CAUSE MORTALITY;
   DENSITY-LIPOPROTEIN CHOLESTEROL; LEFT-VENTRICULAR MASS;
   CARDIORESPIRATORY FITNESS; ATRIAL-FIBRILLATION; RISK-FACTORS; METABOLIC
   SYNDROME; HEART-FAILURE
AB Obesity has reached epidemic proportions both in the United States and worldwide. There are numerous adverse effects on cardiac structure, hemodynamics, and cellular abnormalities, as well as increases in cardiovascular disease (CVD) risk factors such as hypertension, coronary heart disease, dyslipidemia, atrial fibrillation, and depression. Despite these overwhelming findings, large amounts of evidence support the presence of an "obesity paradox," where obese patients with CVD have a better prognosis than do lean or normal weight in patients with CVD. This review discusses the role of obesity in CVD risk factors and the implications of the obesity paradox in this subset of patients.
RI Lavie, Carl/A-6014-2011
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NR 100
TC 41
Z9 45
U1 1
U2 29
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0146-2806
EI 1535-6280
J9 CURR PROB CARDIOLOGY
JI Curr. Probl. Cardiol.
PD NOV
PY 2017
VL 42
IS 11
BP 376
EP 394
DI 10.1016/j.cpcardio1.2017.04.004
PG 19
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA FJ5KH
UT WOS:000412789900002
PM 28965561
DA 2025-06-11
ER

PT J
AU Aouira, N
   Khan, S
   Heussler, H
   Haywood, A
   Karaksha, A
   Bor, W
AF Aouira, Nisreen
   Khan, Sohil
   Heussler, Helen
   Haywood, Alison
   Karaksha, Abdullah
   Bor, William
TI Understanding the Perspective of Youths on Undergoing Metabolic
   Monitoring While on Second-Generation Antipsychotics: Challenges,
   Insight, and Implications
SO JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY
LA English
DT Article
DE youths; perspective; antipsychotics; barriers; suggestions; health
ID PSYCHOTROPIC MEDICATION; PHYSICAL-ACTIVITY; EXPERIENCE; BARRIERS;
   DEPRESSION; ADOLESCENTS; CHILDREN; CARE; PARTICIPATION; PERCEPTIONS
AB Introduction: Prescription of second-generation antipsychotics (SGAs) in youths is rapidly increasing globally, despite the potential for significant adverse effects and long-term health consequences. A known adverse reaction resulting from SGAs is metabolic syndrome (MS). Youths exposed to antipsychotics are at higher risk than adults for adverse drug reactions, including adverse events such as MS (with weight gain as the most significant adverse outcome) and other long-term endocrinological abnormalities. This study aimed to explore the experiences of young patients on factors impacting barriers to metabolic monitoring of SGAs and the strategies to address those barriers thereby providing further guidance on policy and service delivery.Methods: Semi-structured interviews were conducted with patients (youths who were prescribed SGAs) who attended Child and Youth Mental Health Services. The interviews focused on barriers to monitoring and strategies to enhance rates of monitoring that could be customized across study sites.Results: Young patients revealed that none of them had any concerns or objections to receiving anthropometric metabolic measurements. However, they seemed concerned to undergo blood tests as part of the metabolic monitoring process. Specifically, youths cited their fear of the needles as barrier to undergo the required blood tests. Youths have also reported that their dislike to healthy foods and exercise being the most common challenge they face while trying to engage in a healthy lifestyle to manage the SGAs resulted weight gain.Conclusion: Prescribers are recommended to actively engage young patients about the expected SGAs-induced adverse effects, the importance of conducting metabolic monitoring, and how to prevent and minimize the expected adverse effects from the start of initiating SGAs. This could be a vital step toward a successful treatment as the insight of youths into the details of the chosen treatment can play a significant role into treatment adherence and recovery.
C1 [Aouira, Nisreen; Khan, Sohil; Haywood, Alison; Karaksha, Abdullah] Griffith Univ, Menzies Hlth Inst Queensland, Sch Pharm & Med Sci, Gold Coast, Australia.
   [Khan, Sohil; Heussler, Helen; Haywood, Alison; Bor, William] Univ Queensland, Mater Res Inst, Brisbane, Australia.
   [Khan, Sohil] Prasanna Inst Publ Hlth, Manipal, India.
   [Khan, Sohil] Manipal Acad Higher Educ, Manipal Coll Pharmaceut Sci, Manipal, India.
   [Heussler, Helen; Bor, William] Childrens Hlth Queensland Hosp & Hlth Serv, Brisbane, Australia.
   [Bor, William] Queensland Hlth, Ctr Childrens Hlth Res, Child & Youth Mental Hlth Serv, Brisbane, Australia.
   [Aouira, Nisreen] Griffith Univ, Menzies Hlth Inst Queensland, Sch Pharm & Med Sci, Gold Coast 4222, Australia.
C3 Menzies Health Institute Queensland; Griffith University; Griffith
   University - Gold Coast Campus; University of Queensland; Mater
   Research; Manipal Academy of Higher Education (MAHE); Childrens Health
   Queensland Hospital & Health Service; Queensland Health; Menzies Health
   Institute Queensland; Griffith University; Griffith University - Gold
   Coast Campus
RP Aouira, N (corresponding author), Griffith Univ, Menzies Hlth Inst Queensland, Sch Pharm & Med Sci, Gold Coast 4222, Australia.
EM n.aouira@griffith.edu.au
RI Bor, William/J-2215-2015
OI Haywood, Alison/0000-0002-5354-8868; Aouira, Nisreen/0000-0001-9297-6737
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NR 49
TC 1
Z9 1
U1 0
U2 1
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1044-5463
EI 1557-8992
J9 J CHILD ADOL PSYCHOP
JI J. Child Adolesc. Psychopharmacol.
PD SEP 1
PY 2023
VL 33
IS 7
BP 279
EP 286
DI 10.1089/cap.2023.0016
EA JUL 2023
PG 8
WC Pediatrics; Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics; Pharmacology & Pharmacy; Psychiatry
GA S3GE8
UT WOS:001037832600001
PM 37504897
DA 2025-06-11
ER

PT J
AU Tarar, BI
   Knox, A
   Dean, CA
   Brown, EC
AF Tarar, Bilal Ihsan
   Knox, Allan
   Dean, Caress Alithia
   Brown, Elise Catherine
TI Resistance training responses across race and ethnicity: a narrative
   review
SO ETHNICITY & HEALTH
LA English
DT Review
DE Resistance exercise; cardiometabolic risk factors; muscle strength;
   vascular endothelial growth factors; cholesterol; LDL; HDL; blood
   pressure; vascular stiffness; body mass index; waist circumference;
   insulin resistance; glucose; inflammation; c-reactive protein
ID YOUNG AFRICAN-AMERICAN; C-REACTIVE PROTEIN; RACIAL-DIFFERENCES; DIABETES
   MORTALITY; ENERGY-EXPENDITURE; OXIDATIVE STRESS; WEIGHT-LOSS; EXERCISE;
   MASS; STRENGTH
AB ObjectivesAlthough the physiological mechanisms are not fully understood, race/ethnicity differences vary across cardiometabolic disease risk factors. Resistance training (RT) is an effective therapy for improving these risk factors in addition to body composition and physical performance. Thus, the purpose of this study was to determine the effects of RT over time on different racial and ethnic populations across cardiometabolic, body composition, and physical performance outcomes.DesignElectronic databases Scopus and PubMed were searched for studies that compared different racial/ethnic responses to RT across cardiometabolic, body composition, and physical performance parameters. Inclusion criteria for the studies were as follows: (1) published in the English language; (2) compared races or ethnicities across cardiometabolic risk factors, body composition, or physical performance variables following a RT intervention; (3) included adults 18 years or older, and (4) included an isolated RT intervention group.ResultsNine studies were found that met the inclusion criteria. The identified studies involved cohorts of White American (WA), South Asian, European Chilean, Mapuche Chilean, White Scottish, and African American (AA) males and females. Race/ethnicity differences following a RT intervention were found for fat-free mass preservation and changes in blood pressure, endothelial function, brachial artery stiffness, cardiac autonomic function, inflammatory and oxidative stress markers, insulin sensitivity, body mass index, waist circumference, % body fat, and muscular strength. With the exception of changes in systolic blood pressure and brachial artery stiffness, AAs consistently showed more beneficial adaptations compared to WAs to RT across studies.ConclusionRace and ethnicity play a role in how adults adapt to chronic RT. These data may aid in better understanding the social, biological, and environmental factors that likely influenced these racial/ethnic differences in response to RT, assist in creating tailored exercise prescriptions for various racial/ethnic populations, and inform policies for determining resource allocations to address health inequities.
C1 [Tarar, Bilal Ihsan] Oakland Univ, Sch Hlth Sci, Dept Interdisciplinary Hlth Sci, Rochester, MI USA.
   [Knox, Allan] Calif Lutheran Univ, Coll Arts & Sci, Dept Exercise Sci, Thousand Oaks, CA USA.
   [Dean, Caress Alithia; Brown, Elise Catherine] Oakland Univ, Sch Hlth Sci, Dept Publ & Environm Wellness, Rochester, MI USA.
   [Brown, Elise Catherine] Oakland Univ, Sch Hlth Sci, Dept Publ & Environm Wellness, 433 Meadow Brook Rd, Rochester, MI 48309 USA.
   [Tarar, Bilal Ihsan] Oakland Univ, William Beaumont Sch Med, Rochester, MI USA.
C3 Oakland University; California Lutheran University; Oakland University;
   Oakland University; Oakland University
RP Brown, EC (corresponding author), Oakland Univ, Sch Hlth Sci, Dept Publ & Environm Wellness, 433 Meadow Brook Rd, Rochester, MI 48309 USA.
EM elisebrown@oakland.edu
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NR 50
TC 1
Z9 1
U1 0
U2 2
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 1355-7858
EI 1465-3419
J9 ETHNIC HEALTH
JI Ethn. Health
PD NOV 17
PY 2023
VL 28
IS 8
BP 1221
EP 1237
DI 10.1080/13557858.2023.2212147
EA MAY 2023
PG 17
WC Ethnic Studies; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Ethnic Studies; Public, Environmental & Occupational Health
GA X7CT8
UT WOS:000987109500001
PM 37183720
DA 2025-06-11
ER

PT J
AU Amara-Leffad, LO
   Ramdane, H
   Nekhoul, K
   Ouznadji, A
   Koceir, EA
AF Amara-Leffad, Lydia Ould
   Ramdane, Houria
   Nekhoul, Khaoula
   Ouznadji, Amira
   Koceir, Elhadj Ahmed
TI Spirulina effect on modulation of toxins provided by food, impact
   on hepatic and renal functions
SO ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
LA English
DT Article
DE Oxidative stress; inflammatory status; hepatic steatosis; renal
   insufficiency; oxidised oil; Spirulina; metabolic syndrome
ID FATTY LIVER-DISEASE; OXIDATIVE STRESS; FUSIFORMIS; KIDNEY
AB Spirulina platensis, is an alga rich in phycocyanin (potent antioxidant), is effective in regulating the balance of oxidative stress. The objective of this study is to observe the impact of ingestion of a highly oxidised vegetable oil, by rats of Wistar strain. Finally, we observe the effect of Spirulina used as an antioxidant treatment, on rats having ingested a diet rich in highly oxidised oil. Physiological, biochemical and histological studies have been carried out; the oxidative stress parameters evaluated and a dosing of Cytochrome P450 2E1 was finally carried out. Following the introduction of highly oxidised vegetable oil, rats showed deterioration in their metabolic state, an imbalance in the balance of oxidative stress, an increase in serum concentrations of Cytochrome P450 2E1 and significant hepatic lesions. The administration of a daily dose of Spirulina reduces the deleterious effect of oxidative stress induced by a diet enriched with lipid peroxides.
C1 [Amara-Leffad, Lydia Ould; Ramdane, Houria; Koceir, Elhadj Ahmed] USTHB, Bioenerget & Intermediary Metab Lab, Dept Biol Sci & Physiol, Algiers, Algeria.
   [Nekhoul, Khaoula] Algiers Univ 1, Lab Pharmacol, Algiers, Algeria.
   [Ouznadji, Amira] Algiers Univ 1, Lab Biochem, Algiers, Algeria.
C3 University Science & Technology Houari Boumediene
RP Amara-Leffad, LO (corresponding author), USTHB, Bioenerget & Metab Intermediaire, LBPO, FSB, Algiers, Algeria.
EM ouldamaralydia@gmail.com
OI KOCEIR, Elhadj-Ahmed/0000-0003-1345-2535
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NR 53
TC 6
Z9 6
U1 0
U2 10
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1381-3455
EI 1744-4160
J9 ARCH PHYSIOL BIOCHEM
JI Arch. Physiol. Biochem.
PD MAR 15
PY 2019
VL 125
IS 2
BP 184
EP 194
DI 10.1080/13813455.2018.1444059
PG 11
WC Biochemistry & Molecular Biology; Biophysics; Endocrinology &
   Metabolism; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Endocrinology &
   Metabolism; Physiology
GA HQ4FY
UT WOS:000462366900012
PM 29484960
DA 2025-06-11
ER

PT J
AU Liu, YQ
   Fan, Y
   Liu, JB
   Liu, XY
   Li, XY
   Hu, JQ
AF Liu, Yuqiao
   Fan, Yue
   Liu, Jibin
   Liu, Xiyang
   Li, Xiuyan
   Hu, Jingqing
TI Application and mechanism of Chinese herb medicine in the treatment of
   non-alcoholic fatty liver disease
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Review
DE non-alcoholic fatty liver disease (NAFLD); Chinese herb medicine (CHM);
   insulin resistance; lipid metabolism disorder; mitochondrial
   dysfunction; oxidative stress; endoplasmic reticulum stress
ID ENDOPLASMIC-RETICULUM STRESS; DE-NOVO LIPOGENESIS; HEPATIC STEATOSIS;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; VITAMIN-E; MITOCHONDRIAL
   DYSFUNCTION; SIGNALING PATHWAY; TANSHINONE IIA; X-RECEPTOR
AB Non-alcoholic fatty liver disease (NAFLD) is a chronic liver condition closely associated with metabolic syndrome, with its incidence rate continuously rising globally. Recent studies have shown that the development of NAFLD is associated with insulin resistance, lipid metabolism disorder, oxidative stress and endoplasmic reticulum stress. Therapeutic strategies for NAFLD include lifestyle modifications, pharmacological treatments, and emerging biological therapies; however, there is currently no specific drug to treat NAFLD. However Chinese herb medicine (CHM) has shown potential in the treatment of NAFLD due to its unique therapeutic concepts and methods for centuries in China. This review aims to summarize the pathogenesis of NAFLD and some CHMs that have been shown to have therapeutic effects on NAFLD, thus enriching the scientific connotation of TCM theories and facilitating the exploration of TCM in the treatment of NAFLD.
C1 [Liu, Yuqiao; Fan, Yue; Liu, Jibin; Liu, Xiyang; Li, Xiuyan; Hu, Jingqing] Chengdu Univ Tradit Chinese Med, Coll Basic Med Sci, Chengdu, Peoples R China.
   [Hu, Jingqing] Xin Huangpu Joint Innovat Inst Chinese Med, Guangzhou, Peoples R China.
C3 Chengdu University of Traditional Chinese Medicine
RP Hu, JQ (corresponding author), Chengdu Univ Tradit Chinese Med, Coll Basic Med Sci, Chengdu, Peoples R China.; Hu, JQ (corresponding author), Xin Huangpu Joint Innovat Inst Chinese Med, Guangzhou, Peoples R China.
EM gcp306@126.com
RI Liu, Jibin/NGC-2812-2025
FU National Natural Science Foundation of China [82074316]; Sichuan Science
   and Technology Program [2024NSFSC1829]
FX The author(s) declare that financial support was received for the
   research, authorship, and/or publication of this article. This study was
   funded by the National Natural Science Foundation of China (No.
   82074316) and Sichuan Science and Technology Program (No.
   2024NSFSC1829).
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NR 182
TC 3
Z9 3
U1 18
U2 18
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD NOV 13
PY 2024
VL 15
AR 1499602
DI 10.3389/fphar.2024.1499602
PG 23
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA N3D5Y
UT WOS:001363186900001
PM 39605910
OA gold
DA 2025-06-11
ER

PT J
AU Terenzi, DC
   Trac, JZ
   Teoh, H
   Gerstein, HC
   Bhatt, DL
   Al-Omran, M
   Verma, S
   Hess, DA
AF Terenzi, Danielle C.
   Trac, Justin Z.
   Teoh, Hwee
   Gerstein, Hertzel C.
   Bhatt, Deepak L.
   Al-Omran, Mohammed
   Verma, Subodh
   Hess, David A.
TI Vascular Regenerative Cell Exhaustion in Diabetes: Translational
   Opportunities to Mitigate Cardiometabolic Risk
SO TRENDS IN MOLECULAR MEDICINE
LA English
DT Review
ID ENDOTHELIAL PROGENITOR CELLS; BONE-MARROW MICROENVIRONMENT; INTENSIVE
   MEDICAL THERAPY; STEM-CELLS; SELF-RENEWAL; BARIATRIC SURGERY;
   CARDIOVASCULAR OUTCOMES; EXTRACELLULAR VESICLES; SIGNALING PATHWAYS;
   CRITICAL COMPONENT
AB Ischemic cardiovascular complications remain a major cause of mortality in people with type 2 diabetes (T2D). Individuals with T2D may have a reduced ability to revascularize ischemic, tissues due to abnormal production of circulating provascular progenitor cells. This 'regenerative cell exhaustion' process is intensified by increasing oxidative stress and inflammation and during T2D progression. Chronic exhaustion may be mediated by changes in the bone marrow microenvironment that dysregulate the wingless related integration site network, a central pathway maintaining the progenitor cell pool. Restoration of vascular regenerative cell production by reducing glucotoxicity with contemporary antihyperglycemic agents, by reducing systemic inflammation postbariatric surgery, or by modulating progenitor cell provascular functions using exosomal manipulation, may provide unique approaches for mitigating ischemic disease.
C1 [Terenzi, Danielle C.; Trac, Justin Z.; Teoh, Hwee; Verma, Subodh] St Michaels Hosp, Div Cardiac Surg, Toronto, ON M5B 1W8, Canada.
   [Terenzi, Danielle C.; Trac, Justin Z.; Teoh, Hwee; Al-Omran, Mohammed; Verma, Subodh] St Michaels Hosp, Keenan Res Ctr Biomed Sci, Toronto, ON M5B 1T8, Canada.
   [Terenzi, Danielle C.; Trac, Justin Z.; Teoh, Hwee; Al-Omran, Mohammed; Verma, Subodh] St Michaels Hosp, Li Ka Shing Knowledge Inst, Toronto, ON M5B 1T8, Canada.
   [Terenzi, Danielle C.; Al-Omran, Mohammed; Verma, Subodh] Univ Toronto, Inst Med Sci, Toronto, ON M5S 1A1, Canada.
   [Trac, Justin Z.; Al-Omran, Mohammed; Verma, Subodh; Hess, David A.] Univ Toronto, Dept Pharmacol & Toxicol, Toronto, ON M5S 1A8, Canada.
   [Teoh, Hwee] St Michaels Hosp, Div Endocrinol & Metab, Med Ctr, Toronto, ON M5C 2T2, Canada.
   [Gerstein, Hertzel C.] McMaster Univ & Hamilton Hlth Sci, Populat Hlth Res Inst, Div Endocrinol & Metab, Hamilton, ON L8S 4K1, Canada.
   [Bhatt, Deepak L.] Harvard Med Sch, Brigham & Womens Hosp, Heart & Vasc Ctr, Boston, MA 02115 USA.
   [Al-Omran, Mohammed; Hess, David A.] St Michaels Hosp, Div Vasc Surg, Toronto, ON M5B 1W8, Canada.
   [Al-Omran, Mohammed; Verma, Subodh] Univ Toronto, Dept Surg, Toronto, ON M5T 1P5, Canada.
   [Al-Omran, Mohammed] King Saud Univ, Dept Surg, Riyadh 11451, Saudi Arabia.
   [Hess, David A.] Western Univ, Dept Physiol & Pharmacol, London, ON N6A 5C1, Canada.
   [Hess, David A.] Western Univ, Robarts Res Inst, London, ON N6A 5B7, Canada.
C3 University of Toronto; Saint Michaels Hospital Toronto; University of
   Toronto; Saint Michaels Hospital Toronto; University of Toronto; Saint
   Michaels Hospital Toronto; Li Ka Shing Knowledge Institute; University
   of Toronto; University of Toronto; University of Toronto; Saint Michaels
   Hospital Toronto; Population Health Research Institute; McMaster
   University; McMaster University Hospital; Harvard University; Harvard
   University Medical Affiliates; Brigham & Women's Hospital; Harvard
   Medical School; University of Toronto; Saint Michaels Hospital Toronto;
   University of Toronto; King Saud University; Western University
   (University of Western Ontario); Western University (University of
   Western Ontario); University Western Ontario Hospital
RP Hess, DA (corresponding author), Univ Toronto, Dept Pharmacol & Toxicol, Toronto, ON M5S 1A8, Canada.; Hess, DA (corresponding author), St Michaels Hosp, Div Vasc Surg, Toronto, ON M5B 1W8, Canada.; Hess, DA (corresponding author), Western Univ, Dept Physiol & Pharmacol, London, ON N6A 5C1, Canada.; Hess, DA (corresponding author), Western Univ, Robarts Res Inst, London, ON N6A 5B7, Canada.
EM dhess@robarts.ca
RI Teoh, Hwee/F-2498-2018; Gerstein, Hertzel/B-1235-2013; Verma,
   Subodh/HCH-3619-2022; Hess, David/M-2828-2013; Al-Omran,
   Mohammed/IXX-0542-2023; Bhatt, Deepak L./Y-3070-2019
OI Hess, David/0000-0003-2186-3166; Bhatt, Deepak L./0000-0002-1278-6245;
   Gerstein, Hertzel/0000-0001-8072-2836
FU Canadian Institutes of Health Research; Heart and Stroke Foundation;
   Canadian Institutes of Health Research (MOP) [378189]
FX Dr Verma holds a Canada Research Chair in Cardiovascular Surgery and has
   received grants from the Canadian Institutes of Health Research and the
   Heart and Stroke Foundation. Dr Hess has received a grant from the
   Canadian Institutes of Health Research (MOP#378189).
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NR 94
TC 21
Z9 24
U1 0
U2 8
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1471-4914
EI 1471-499X
J9 TRENDS MOL MED
JI Trends Mol. Med
PD JUL
PY 2019
VL 25
IS 7
BP 640
EP 655
DI 10.1016/j.molmed.2019.03.006
PG 16
WC Biochemistry & Molecular Biology; Cell Biology; Medicine, Research &
   Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology; Research & Experimental
   Medicine
GA IH2YQ
UT WOS:000474360900008
PM 31053416
DA 2025-06-11
ER

PT J
AU Rutledge, T
   Linke, SE
   Johnson, BD
   Bittner, V
   Krantz, DS
   Cornell, CE
   Vaccarino, V
   Pepine, CJ
   Handberg, EM
   Eteiba, W
   Shaw, LJ
   Parashar, S
   Eastwood, JA
   Vido, DA
   Merz, CNB
AF Rutledge, Thomas
   Linke, Sarah E.
   Johnson, B. Delia
   Bittner, Vera
   Krantz, David S.
   Cornell, Carol E.
   Vaccarino, Viola
   Pepine, Carl J.
   Handberg, Eileen M.
   Eteiba, Wafia
   Shaw, Leslee J.
   Parashar, Susmita
   Eastwood, Jo-Ann
   Vido, Diane A.
   Merz, C. Noel Bairey
TI Relationships Between Cardiovascular Disease Risk Factors and Depressive
   Symptoms as Predictors of Cardiovascular Disease Events in Women
SO JOURNAL OF WOMENS HEALTH
LA English
DT Article
ID CORONARY-HEART-DISEASE; SYNDROME EVALUATION WISE; MYOCARDIAL-INFARCTION;
   52 COUNTRIES; POSTMENOPAUSAL WOMEN; METABOLIC SYNDROME;
   DIABETES-MELLITUS; OLDER-ADULTS; NHANES-I; ASSOCIATION
AB Background: Modifiable risk factors for cardiovascular disease (CVD) account for much of the variability in CVD outcomes and are also related to psychosocial variables. There is evidence that depression can undermine the treatment and advance the progression of CVD risk factors, suggesting that CVD risk factor relationships with CVD events may differ among those with depression.
   Methods: This study tracked CVD events and mortality over a median of 5.9 years among a prospective cohort of 620 women (mean age 59.6 years [11.6]) completing a diagnostic protocol including coronary angiography and CVD risk factor assessment. Depressive symptoms were assessed using the Beck Depression Inventory (BDI). The study outcome was combined cardiovascular mortality and events.
   Results: Over the follow-up interval, 16.1% of the sample experienced one or more of the cardiovascular outcomes. In separate Cox regression models adjusting for age, education history, ethnicity, and coronary angiogram scores, we observed statistically significant CVD risk factor x BDI score interactions for diabetes, smoking, and waist-hip ratio factors. Simple effect analyses indicated that diabetes and smoking status were more strongly associated with cardiovascular outcomes among participants with lower BDI scores, whereas waist-hip ratio values predicted outcomes only among those with higher BDI scores.
   Conclusions: These results suggest that the relationship between modifiable CVD risk factors and CVD outcomes may vary with depression status in clinical samples of women. This evidence augments prior research by demonstrating that depression may influence CVD risk jointly with or independent of CVD risk factors. It also provides further support for the inclusion of depression assessment in cardiovascular clinic settings.
C1 [Rutledge, Thomas] VA San Diego Healthcare Syst, Psychol Serv 116B, Med Ctr, San Diego, CA 92161 USA.
   [Rutledge, Thomas] Univ Calif San Diego, Dept Psychiat, San Diego, CA 92103 USA.
   [Linke, Sarah E.] Univ Calif San Diego, San Diego State Univ, San Diego Joint Doctoral Program Clin Psychol, San Diego, CA 92103 USA.
   [Johnson, B. Delia; Eteiba, Wafia] Univ Pittsburgh, Grad Sch Publ Hlth, Pittsburgh, PA USA.
   [Bittner, Vera] Univ Alabama, Dept Med, Birmingham, AL 35294 USA.
   [Krantz, David S.] Uniformed Serv Univ Hlth Sci, Dept Med & Clin Psychol, Bethesda, MD 20814 USA.
   [Cornell, Carol E.] Univ Arkansas Med Sci, Dept Hlth Behav & Hlth Educ, Little Rock, AR 72205 USA.
   [Vaccarino, Viola; Parashar, Susmita] Emory Univ, Rollins Sch Publ Hlth, Dept Epidemiol, Atlanta, GA 30322 USA.
   [Pepine, Carl J.; Handberg, Eileen M.] Univ Florida, Gainesville, FL USA.
   [Shaw, Leslee J.] Univ Arkansas Med Sci, Dept Med, Little Rock, AR 72205 USA.
   [Eastwood, Jo-Ann] Univ Calif Los Angeles, Sch Nursing, Los Angeles, CA 90024 USA.
   [Vido, Diane A.] Allegheny Gen Hosp, Pittsburgh, PA 15212 USA.
   [Merz, C. Noel Bairey] Cedars Sinai Heart Inst, Womens Heart Ctr, Los Angeles, CA USA.
C3 US Department of Veterans Affairs; Veterans Health Administration (VHA);
   VA San Diego Healthcare System; University of California System;
   University of California San Diego; University of California System;
   University of California San Diego; California State University System;
   San Diego State University; Pennsylvania Commonwealth System of Higher
   Education (PCSHE); University of Pittsburgh; University of Alabama
   System; University of Alabama Birmingham; Uniformed Services University
   of the Health Sciences - USA; University of Arkansas System; University
   of Arkansas Medical Sciences; Emory University; Rollins School Public
   Health; State University System of Florida; University of Florida;
   University of Arkansas System; University of Arkansas Medical Sciences;
   University of California System; University of California Los Angeles;
   Allegheny Health Network; Allegheny General Hospital; Cedars Sinai
   Medical Center
RP Rutledge, T (corresponding author), VA San Diego Healthcare Syst, Psychol Serv 116B, Med Ctr, 3350 La Jolla Village Dr, San Diego, CA 92161 USA.
EM thomas.rutledge@va.gov
RI Krantz, David/L-5364-2015; Vaccarino, Viola/AAW-5600-2020; Parashar,
   Susmita/GYJ-3885-2022; Shaw, Leslee/ABG-4621-2022
OI Krantz, David/0000-0002-1671-1355; Bittner, Vera/0000-0001-9456-850X;
   Handberg, Eileen/0000-0002-7805-9577; Vaccarino, Laura
   Viola/0000-0002-9054-0654
FU National Heart, Lung and Blood Institutes [N01-HV-68161, N01-HV-68162,
   N01-HV-68163, N01-HV-68164, U0164829, U01 HL649141, U01 HL649241];
   National Center for Research Resources [MO1-RR00425]; Gustavus and Louis
   Pfeiffer Research Foundation, Denville, New Jersey; Women's Guild of
   Cedars-Sinai Medical Center, Los Angeles, California; Ladies Hospital
   Aid Society of Western Pennsylvania, Pittsburgh, Pennsylvania; Edythe
   Broad Endowment for Women's Heart Research, Los Angeles, California
FX This work was supported by contracts from the National Heart, Lung and
   Blood Institutes (N01-HV-68161, N01-HV-68162, N01-HV-68163,
   N01-HV-68164) and grants (U0164829, U01 HL649141, U01 HL649241), a
   General Clinical Research Center grant (MO1-RR00425) from the National
   Center for Research Resources, and grants from the Gustavus and Louis
   Pfeiffer Research Foundation, Denville, New Jersey; The Women's Guild of
   Cedars-Sinai Medical Center, Los Angeles, California; The Ladies
   Hospital Aid Society of Western Pennsylvania, Pittsburgh, Pennsylvania;
   and The Edythe Broad Endowment for Women's Heart Research, Los Angeles,
   California. The first author takes full responsibility for the accuracy
   of the statistical results and all authors had access to the WISE data.
   All authors contributed to the development of this manuscript in
   important ways, including study design, data collection, participating
   in multiple internal drafts for editorial purposes, group discussion of
   findings, and data analysis. The article received approval for
   publication by the WISE P&P committee and the participating authors.
CR [Anonymous], DEPRESSION INVENTORY
   [Anonymous], AM J PUBLIC HEALTH
   [Anonymous], JAMA
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NR 40
TC 29
Z9 34
U1 0
U2 8
PU MARY ANN LIEBERT INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-9996
J9 J WOMENS HEALTH
JI J. Womens Health
PD FEB
PY 2012
VL 21
IS 2
BP 133
EP 139
DI 10.1089/jwh.2011.2787
PG 7
WC Public, Environmental & Occupational Health; Medicine, General &
   Internal; Obstetrics & Gynecology; Women's Studies
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; General & Internal
   Medicine; Obstetrics & Gynecology; Women's Studies
GA 891TV
UT WOS:000300240400005
PM 21988550
OA Green Published, Green Accepted
DA 2025-06-11
ER

PT J
AU Giusti, L
   Bianchini, V
   Aggio, A
   Mammarella, S
   Salza, A
   Necozione, S
   Alunno, A
   Ferri, C
   Casacchia, M
   Roncone, R
AF Giusti, Laura
   Bianchini, Valeria
   Aggio, Annalisa
   Mammarella, Silvia
   Salza, Anna
   Necozione, Stefano
   Alunno, Alessia
   Ferri, Claudio
   Casacchia, Massimo
   Roncone, Rita
TI Twelve-month outcomes in overweight/obese users with mental disorders
   following a multi-element treatment including diet, physical activity,
   and positive thinking: The real-world "An Apple a Day" controlled trial
SO FRONTIERS IN PSYCHIATRY
LA English
DT Article
DE diet protocol; physical activity; metacognitive group intervention;
   cardiovascular risk; mental disorders; obesity; metabolic syndrome;
   psychopharmacological treatment
ID MAJOR DEPRESSIVE DISORDER; INDUCED WEIGHT-GAIN; QUALITY-OF-LIFE;
   RISK-FACTORS; CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME;
   SCHIZOAFFECTIVE DISORDER; BIPOLAR DISORDER; BODY-WEIGHT; HEALTH
AB The present study aimed to evaluate the 12-month effectiveness of a real-world weight loss transdiagnostic intervention in overweight/obese participants affected by mental disorders under psychopharmacological treatment. We conducted a real-world, controlled, pragmatic outpatient trial. We allocated 58 overweight/obese adults under psychopharmacological treatment from a mental health outpatient unit and 48 overweight/obese adults from a cardiovascular prevention outpatient unit, and assigned them to an intervention or treatment usual as condition (TAU) enriched by life-style advice. Participants in both intervention groups took part in a diet programme (the modified OMNIHeart dietary protocol) and monitoring of regular aerobic activity. A brief group programme ("An Apple a Day" Metacognitive Training, Apple-MCT) was added in the intervention group of participants affected by mental disorders. The primary outcome was weight loss. Secondary outcomes included anthropometric, clinical, and metabolic variables. Psychopathology and health-related quality of life were also evaluated in the psychiatric sample. At 12 months, both intervention groups showed a more marked mean decrease in weight (6.7 kg, SD: 3.57) than the TAU group (0.32 kg, SD: 1.96), and a statistically significant improvement in metabolic variables compared with the control groups. Furthermore, the participants affected by mental disorders included in the intervention group reported improved health-related quality of life. Our findings suggest the need to implement integrated interventions based on a dietary protocol, physical activity, and modification of cognitive style in overweight/obese users with mental disorders.
C1 [Giusti, Laura; Bianchini, Valeria; Aggio, Annalisa; Mammarella, Silvia; Salza, Anna; Necozione, Stefano; Casacchia, Massimo] Univ LAquila, Dept Life Hlth & Environm Sci, LAquila, Italy.
   [Alunno, Alessia; Ferri, Claudio] Univ LAquila, San Salvatore Hosp, Sch Internal Med, Dept Life, LAquila, Italy.
   [Roncone, Rita] Univ LAquila, San Salvatore Hosp, Univ Unit Rehabil Treatment, Dept Life Hlth & Environm Sci,Early Intervent Ment, LAquila, Italy.
C3 University of L'Aquila; University of L'Aquila; University of L'Aquila
RP Roncone, R (corresponding author), Univ LAquila, San Salvatore Hosp, Univ Unit Rehabil Treatment, Dept Life Hlth & Environm Sci,Early Intervent Ment, LAquila, Italy.
EM rita.roncone@univaq.it
RI Giusti, Laura/AGF-0849-2022; Roncone, Rita/H-3095-2012; Alunno,
   Alessia/AAC-8842-2022; Salza, Anna/IQR-9478-2023; Mammarella,
   Silvia/IQR-9276-2023
OI Mammarella, Silvia/0009-0008-2045-5981; Alunno,
   Alessia/0000-0003-1105-5640; Casacchia, Massimo/0000-0003-1015-3919
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   ,, 2010, Global recommendations on physical activity for health
NR 106
TC 4
Z9 4
U1 1
U2 11
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-0640
J9 FRONT PSYCHIATRY
JI Front. Psychiatry
PD AUG 23
PY 2022
VL 13
AR 903759
DI 10.3389/fpsyt.2022.903759
PG 20
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 5O6LV
UT WOS:000872583200001
PM 36081460
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Centorrino, F
   Mark, TL
   Talamo, A
   Oh, K
   Chang, J
AF Centorrino, Franca
   Mark, Tami L.
   Talamo, Alessandra
   Oh, Kelly
   Chang, Jane
TI Health and Economic Burden of Metabolic Comorbidity Among Individuals
   With Bipolar Disorder
SO JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
LA English
DT Article
DE bipolar disorder; diabetes; angina; dyslipidemia; hypertension;
   metabolic syndrome; metabolic comorbidity; medical comorbidity; burden
ID MAJOR DEPRESSION; MEDICAL BURDEN; I DISORDER; POPULATION; PREVALENCE;
   OVERWEIGHT; MORTALITY; ILLNESS; OBESITY; COSTS
AB Objectives: To compare the prevalence and health care costs of metabolic conditions in patients with bipolar disorder to age- and sex-matched control patients using a large insurance claims database.
   Methods: A retrospective analysis of medical service and prescription claims from the Thomson Reuters (Healthcare) MarketScan Commercial Database (which includes claims information on >12 million employees with employer-based insurance and their dependents in the United States) was conducted. Claims data for 28,53 1 patients with bipolar disorder were compared for 1 year with data for 85,593 age- and sex-matched control patients with no mental health disorders and no psychotropic medication use.
   Results: Patients with bipolar disorder had a significantly higher prevalence of metabolic comorbidities than the general population (37% vs 30%, P < 0.0001), and annual medical service treatment costs for metabolic conditions were twice that of the control cohort ($531 vs $233, P < 0.0001). The bipolar cohort had significantly higher overall medical service and prescription drug costs than those of the control cohort ($12,764 vs $3,140, P < 0.0001). Prescription medication cost's for metabolic conditions were higher as well, with bipolar cohort per-patient costs of $571 versus $301 for the control cohort (P < 0.0001).
   Conclusions: Patients with bipolar disorder have significantly more metabolic comorbidities and higher medical costs than age- and sex-matched controls. Studies that link claims data with medical records or primary data collection pertaining to metabolic conditions may overcome limitations in the diagnostic information and Outcome predictors. To reduce the medical and economic burden of bipolar disorder, strategies should be identified to prevent the development of metabolic comorbidities and improve medication adherence.
C1 [Centorrino, Franca; Talamo, Alessandra] Harvard Univ, Sch Med, Dept Psychiat, Boston, MA 02115 USA.
   [Centorrino, Franca; Talamo, Alessandra] McLean Hosp, Schizophrenia Bipolar Disorder Program, Belmont, MA 02178 USA.
   [Centorrino, Franca; Talamo, Alessandra] McLean Hosp, Psychopharmacol Program, Belmont, MA 02178 USA.
   [Mark, Tami L.; Oh, Kelly] Thomson Healthcare, Washington, DC USA.
   [Chang, Jane] Novartis Pharmaceut, E Hanover, NJ USA.
C3 Harvard University; Harvard Medical School; Harvard University; Harvard
   University Medical Affiliates; McLean Hospital; Harvard University;
   Harvard University Medical Affiliates; McLean Hospital; Novartis;
   Novartis USA
RP Centorrino, F (corresponding author), Massachusetts Gen Hosp, McLean Div, Schizophrenia Bipolar Disorder Program, Belmont, MA 02478 USA.
EM fcentorrino@mclean.harvard.edu
RI Talamo, Alessandra/GRN-8346-2022
OI Talamo, Alessandra/0000-0001-7321-9247
FU Thomson Healthcare; Novartis Pharmaceuticals Corporation
FX This study was supported in part by access to MarketScan data provided
   by Thomson Healthcare, 4301 Connecticut Ave NW, Suite 330, Washington,
   DC 20008. Funding for this article was provided by Novartis
   Pharmaceuticals Corporation, One Health Plaza, East Hanover. NJ 07936.
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NR 28
TC 42
Z9 43
U1 0
U2 10
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0271-0749
J9 J CLIN PSYCHOPHARM
JI J. Clin. Psychopharmacol.
PD DEC
PY 2009
VL 29
IS 6
BP 595
EP 600
DI 10.1097/JCP.0b013e3181bef8a6
PG 6
WC Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Psychiatry
GA 522NG
UT WOS:000272004300014
PM 19910727
DA 2025-06-11
ER

PT J
AU Sheikh, MA
AF Sheikh, Mashhood Ahmed
TI Child maltreatment, psychopathological symptoms, and onset of diabetes
   mellitus, hypothyroidism and COPD in adulthood
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Diabetes mellitus; Hypothyroidism; Low metabolism; Chronic bronchitis;
   Emphysema; COPD; Childhood maltreatment; Social epidemiology; Social
   causation; Life course
ID EARLY-LIFE ADVERSITY; PSYCHOLOGICAL DISTRESS; MYOCARDIAL-INFARCTION;
   INFLAMMATORY MARKERS; METABOLIC SYNDROME; ALLOSTATIC LOAD; RISK-FACTOR;
   ABUSE; DEPRESSION; HEALTH
AB Background: The aim of this study was to assess the associations between child maltreatment (CM), psychopathological symptoms, and onset of diabetes mellitus, hypothyroidism (i.e., low metabolism), and chronic bronchitis/emphysema/COPD in adulthood.
   Methods: The present analysis used cross-sectional data collected in 2007-2008 within the Troms phi Study, Norway (N = 12,981). CM was measured with a single item, and self-reported information on psychopathological symptoms and physical health outcomes was used. The associations between CM, psychopathological symptoms, and physical health outcomes were assessed with linear and Poisson regression models. Mediation was assessed with difference-in-coefficients method.
   Results: In the fully-adjusted models, CM was associated with higher levels of anxiety and depression, psychological distress, difficulty in sleeping, insomnia, and use of sleeping pills and antidepressants in adulthood (p < 0.05). Moreover, CM was associated with a more than two-folds increased risk of consultation with psychiatrist (p < 0.001), a 26% increased risk of forgetfulness (p < 0.001), a 15% increased risk of decline in memory (p < 0.001), and a 96% increased risk of psychiatric problems (p < 0.001) over the course of life. In the fully-adjusted models, CM was associated with a 27-82% increased risk of physical health outcomes in adulthood (p < 0.05). Indicators of psychopathological symptoms significantly (p < 0.05) mediate the associations between CM and physical health outcomes.
   Limitations: The design of this study is cross-sectional, and all measures are self-reported.
   Conclusion: The associations between retrospectively-reported CM and physical health outcomes in adulthood are partially driven by psychopathological symptoms in adulthood.
C1 [Sheikh, Mashhood Ahmed] Univ Tromso, Dept Community Med, N-9037 Tromso, Norway.
C3 UiT The Arctic University of Tromso
RP Sheikh, MA (corresponding author), Univ Tromso, Dept Community Med, N-9037 Tromso, Norway.
EM mashhood.a.sheikh@uit.no
RI Sheikh, Mashhood Ahmed/D-8599-2018
OI Sheikh, Mashhood Ahmed/0000-0002-3212-592X
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NR 63
TC 11
Z9 14
U1 0
U2 116
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD DEC 1
PY 2018
VL 241
BP 80
EP 85
DI 10.1016/j.jad.2018.07.085
PG 6
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA GS6OK
UT WOS:000443816800011
PM 30099267
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Liu, HY
   Wang, GQ
   Zhao, J
   Hu, J
   Mu, YM
   Gu, WJ
AF Liu, Hongyan
   Wang, Guoqi
   Zhao, Jian
   Hu, Jia
   Mu, Yiming
   Gu, Weijun
TI Association of skin autofluorescence with depressive symptoms and the
   severity of depressive symptoms: The prospective REACTION study
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE Advanced glycation end-products(AGEs); Depressive symptom; Skin
   autofluorescence (SAF)
ID GLYCATION END-PRODUCTS; ENDOGENOUS SECRETORY RECEPTOR; METABOLIC
   SYNDROME; RISK; INDIVIDUALS; DURATION; DISEASE; GLUCOSE; STRESS; LEVEL
AB Aim: Millions of people are afflicted by depression, a highly prevalent mental illness with increased morbidity and mortality. Advanced glycation end-products (AGEs) are potential risk factors for depression. We aimed to investigate the correlation of AGEs with depressive symptoms and the severity of depressive symptoms. Methods: This study was nested in the prospective REACTION (Risk Evaluation of cAncers in Chinese diabeTic Individuals) study and included 4420 eligible participants. skin autofluorescence (SAF) was used to measure skin AGEs. Depressive symptoms were evaluated by the Self-Rating Depression Scale (SDS). Multiple logistic regression analysis was used to assess the association of AGEs with depressive symptoms and the severity of depressive symptoms. Results: Logistic analysis showed a significantly positive relationship between quartiles of SAF-AGEs and the risk of depressive symptoms with the OR [95% confidence interval (CI), p value] of 1.24 (95% CI: 1.03-1.50, p = 0.022), 1.39 (95% CI: 1.15-1.68, p = 0.001) and 1.57 (95% CI: 1.28-1.91, p < 0.001) for multivariable-adjusted model respectively. And SAF-AGEs were associated with the severity of depressive symptoms with the multivariable-adjusted OR (95% CI, p value) of 1.06 (95% CI:0.79-1.43, p = 0.681), 1.47 (95% CI: 1.08-1.99, p = 0.014), and 1.54 (95% CI: 1.12-2.11, p = 0.008) respectively. Stratified analyses showed that SAF-AGEs were significantly associated with the severity of depressive symptoms only in females, overweight people, individuals with hypertension, and those without diabetes and insomnia. Conclusions: The present study showed that a higher SAF-AGEs level was associated with depressive symptoms and the severity of depressive symptoms.
C1 [Liu, Hongyan; Zhao, Jian; Hu, Jia; Mu, Yiming; Gu, Weijun] Chinese Peoples Liberat Army Gen Hosp, Med Ctr 1, Dept Endocrinol, Beijing 100853, Peoples R China.
   [Wang, Guoqi] Chinese Peoples Liberat Army Gen Hosp, Med Ctr 1, Dept Pediat, Beijing 100853, Peoples R China.
   [Mu, Yiming; Gu, Weijun] 28 Fuxing Rd, Beijing 100853, Peoples R China.
C3 Chinese People's Liberation Army General Hospital; Chinese People's
   Liberation Army General Hospital
RP Mu, YM; Gu, WJ (corresponding author), 28 Fuxing Rd, Beijing 100853, Peoples R China.
EM muyiming@301hospital.com; guweijun301@163.com
RI Jian, Zhao/AAJ-8262-2021
FU Beijing Science and Technology Commission of China [Z201100005520014]
FX This study was supported by the Beijing Science and Technology
   Commission of China (project number Z201100005520014) .
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NR 62
TC 0
Z9 0
U1 0
U2 3
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
EI 1873-3360
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD AUG
PY 2023
VL 154
AR 106285
DI 10.1016/j.psyneuen.2023.106285
EA MAY 2023
PG 8
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA I6FQ2
UT WOS:001003726500001
PM 37148715
OA hybrid
DA 2025-06-11
ER

PT J
AU Kolbe, I
   Dumbell, R
   Oster, H
AF Kolbe, Isa
   Dumbell, Rebecca
   Oster, Henrik
TI Circadian Clocks and the Interaction between Stress Axis and Adipose
   Function
SO INTERNATIONAL JOURNAL OF ENDOCRINOLOGY
LA English
DT Review
ID PITUITARY-ADRENAL AXIS; HIGH-FAT DIET; GLUCOCORTICOID REPLACEMENT
   THERAPY; CORTICOTROPIN-RELEASING HORMONE; GENE-EXPRESSION;
   PERIPHERAL-TISSUES; LEPTIN LEVELS; INSULIN-RESISTANCE; METABOLIC
   SYNDROME; DIURNAL RHYTHM
AB Many physiological processes and most endocrine functions show fluctuations over the course of the day. These so-called circadian rhythms are governed by an endogenous network of cellular clocks and serve as an adaptation to daily and, thus, predictable changes in the organism's environment. Circadian clocks have been described in several tissues of the stress axis and in adipose cells where they regulate the rhythmic and stimulated release of stress hormones, such as glucocorticoids, and various adipokine factors. Recent work suggests that both adipose and stress axis clock systems reciprocally influence each other and adrenal-adipose rhythms may be key players in the development and therapy of metabolic disorders. In this review, we summarize our current understanding of adrenal and adipose tissue rhythms and clocks and how they might interact to regulate energy homoeostasis and stress responses under physiological conditions. Potential chronotherapeutic strategies for the treatment of metabolic and stress disorders are discussed.
C1 [Kolbe, Isa; Dumbell, Rebecca; Oster, Henrik] Univ Lubeck, Chronophysiol Grp, Dept Med 1, D-23538 Lubeck, Germany.
C3 University of Lubeck
RP Oster, H (corresponding author), Univ Lubeck, Chronophysiol Grp, Dept Med 1, D-23538 Lubeck, Germany.
EM henrik.oster@uksh.de
RI Dumbell, Rebecca/AES-7678-2022; Oster, Henrik/O-4426-2019; Oster,
   Henrik/D-2335-2013
OI Dumbell, Rebecca/0000-0002-8805-3777; Oster, Henrik/0000-0002-1414-7068
FU German Research Foundation (DFG) [GRK1957]
FX This work is supported by a Grant of the German Research Foundation
   (DFG) to Henrik Oster (GRK1957). Henrik Oster is a Lichtenberg Fellow of
   the Volkswagen Foundation.
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NR 168
TC 21
Z9 27
U1 0
U2 13
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1687-8337
EI 1687-8345
J9 INT J ENDOCRINOL
JI Int. J. Endocrinol.
PY 2015
VL 2015
AR 693204
DI 10.1155/2015/693204
PG 13
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA CH9MR
UT WOS:000354360200001
PM 26000016
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Shelton, RC
   Falola, M
   Li, L
   Zajecka, J
   Fava, M
   Papakostas, GI
AF Shelton, Richard C.
   Falola, Michael
   Li, Li
   Zajecka, John
   Fava, Maurizio
   Papakostas, George I.
TI The pro-inflammatory profile of depressed patients is (partly) related
   to obesity
SO JOURNAL OF PSYCHIATRIC RESEARCH
LA English
DT Article
DE Depression; Inflammation; Cytokine; C-reactive protein; Leptin;
   Adiponectin
ID MAJOR DEPRESSION; TREATMENT RESPONSE; METABOLIC SYNDROME; RISK-FACTOR;
   OLDER MEN; SYMPTOMS; CYTOKINES; STRESS; ADULTS; IL-6
AB Many people with major depressive disorder (MDD) show evidence of systemic inflammation, including elevations in inflammatory factors, but the cause is unclear. The purpose of this analysis was to determine if obesity might contribute to the pro-inflammatory state in MDD patients. Blood was obtained from 135 MDD patients and 50 controls. Serum was extracted and assayed for interleukin (IL) - 1 beta, IL-2, IL-5, IL-6, IL-8, IL-10, IL-12p70, IL-17, interferon-gamma (IFN gamma), tumor necrosis factor alpha (TNF alpha), C-reactive protein (CRP), leptin, and adiponectin using single- or multi-plex human immunoassay kits. The primary analysis contrasted IL-6, TNF alpha, and CRP between MDD and control groups with body mass index (BMI) as a covariate. The other analytes were compared in an exploratory fashion. IL-6 (but not TNF alpha or CRP) showed significant differences between MDD and controls even after covarying for BMI. Obese controls and obese MDD groups were significantly higher in IL-6 than both lean groups, but the two obese groups did not differ from each other. In the exploratory analyses, the IL-2 level showed robust and significant differences between MDD and controls even after covarying for BMI. Both lean and obese MDD were higher than lean and obese controls. Adiponectin levels were also lower in the MDD sample than controls. Prior findings of higher IL-6, and CRP in MDD patients may be explained, at least in part, based on obesity. High IL-2, however, was associated with depression and not obesity. The results have significant implications for the understanding of pathophysiology and, potentially treatment of MDD. (C) 2015 Elsevier Ltd. All rights reserved.
C1 [Shelton, Richard C.; Falola, Michael; Li, Li] Univ Alabama Birmingham, Dept Psychiat, Birmingham, AL 35294 USA.
   [Zajecka, John] Rush Presbyterian St Lukes Med Ctr, Dept Psychiat, Chicago, IL 60612 USA.
   [Fava, Maurizio; Papakostas, George I.] Massachusetts Gen Hosp, Dept Psychiat, Boston, MA 02114 USA.
   [Fava, Maurizio; Papakostas, George I.] Massachusetts Gen Hosp, CTNI, Boston, MA 02114 USA.
C3 University of Alabama System; University of Alabama Birmingham; Rush
   University; Harvard University; Harvard University Medical Affiliates;
   Massachusetts General Hospital; Harvard University; Harvard University
   Medical Affiliates; Massachusetts General Hospital
RP Shelton, RC (corresponding author), Univ Alabama Birmingham, SC 1060,1720 2nd Ave South, Birmingham, AL 35294 USA.
EM rshelton@uab.edu
RI Li, Li/M-3237-2016; Shelton, Richard/AAC-4137-2022; Fava,
   Maurizio/AAH-3548-2020; Papakostas, George/AAF-7461-2021
OI Shelton, Richard/0000-0002-3806-4208
FU NIH National Center for Research Resources [5UL1RR025777-03,
   5KL2RR025776-03, 5TL1RR025775-03]; Brain & Behavior Research Foundation
   and Pamlab, Inc.
FX Support for the sample collection and analysis was provided by the Brain
   & Behavior Research Foundation and Pamlab, Inc. Funding for the REDCAP
   database was provided by the NIH National Center for Research Resources
   as part of its Clinical and Translational Science Award Program
   (5UL1RR025777-03, 5KL2RR025776-03, 5TL1RR025775-03)
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NR 55
TC 50
Z9 52
U1 0
U2 21
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-3956
EI 1879-1379
J9 J PSYCHIATR RES
JI J. Psychiatr. Res.
PD NOV
PY 2015
VL 70
BP 91
EP 97
DI 10.1016/j.jpsychires.2015.09.001
PG 7
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA CU8XG
UT WOS:000363826800011
PM 26424427
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Chandradasa, M
   Champika, L
   de Silva, S
   Kuruppuarachchi, KALA
AF Chandradasa, Miyuru
   Champika, Layani
   de Silva, Silumini
   Kuruppuarachchi, K. A. L. A.
TI Topiramate's effectiveness on weight reduction in overweight/obese
   persons with schizophrenia: study protocol for a randomized controlled
   trial
SO TRIALS
LA English
DT Article
DE Schizophrenia; Antipsychotic agents; Weight loss; Body weight;
   Anticonvulsants; Randomized trial; Protocol; Sri Lanka; Asia
ID METABOLIC SYNDROME; DOUBLE-BLIND; METAANALYSIS; PREVALENCE; DISORDERS;
   MORTALITY; EFFICACY; SAFETY
AB Background: Schizophrenia is a psychiatric disorder with a higher mortality than that of the general population. Most of the deaths are due to cardiovascular causes and are related to metabolic risks. This risk is due not only to antipsychotics but also to inherent factors of the disorder. Studies in the West have shown topiramate to be effective in schizophrenia to reduce weight gain and for symptomatic control. Whether this is effective for South Asians is not known. It is important because South Asians have a higher risk of metabolic syndrome. We aim to conduct a double-blind, randomized controlled trial comparing topiramate add-on therapy with treatment as usual with antipsychotics in patients with schizophrenia in an outpatient setting in Sri Lanka.
   Methods/design: Ninety patients with schizophrenia presenting to the Colombo North Teaching Hospital will be randomized to intervention and control groups equally using permuted block randomization. Patients with comorbid metabolic disorders and taking prescribed weight-controlling medications will be excluded. The intervention group will be prescribed topiramate in addition to their antipsychotics in a predefined dosing regimen targeting a dose of 100 mg per day. The control subjects are to receive a placebo. As the primary outcome, anthropometric measurements including weight, waist circumference, skinfold thickness, and body mass index will be recorded at baseline and monthly during the study period of 3 months. The secondary outcome is the change in symptoms according to the clinician-administered Brief Psychiatric Rating Scale. Assessment of capacity will be performed and informed consent obtained from all subjects. Ethics approval has been obtained from the ethical review committee of the Faculty of Medicine, University of Kelaniya, and the trial has been registered in the Sri Lanka Clinical Trials Registry.
   Discussion: In this double-blind, randomized controlled trial, we will attempt to assess the effectiveness of topiramate as an add-on therapy compared with treatment as usual for weight control in patients with schizophrenia. To our knowledge, this is the first such study in South Asia, where metabolic risks are found to be higher than in the West and could have unique ethnic factors related to weight gain in schizophrenia.
C1 [Chandradasa, Miyuru; Kuruppuarachchi, K. A. L. A.] Univ Kelaniya, Dept Psychiat, Fac Med, Kelaniya, Sri Lanka.
   [Chandradasa, Miyuru; Champika, Layani; de Silva, Silumini; Kuruppuarachchi, K. A. L. A.] Colombo North Teaching Hosp, Ragama, Sri Lanka.
C3 University Kelaniya; University of Colombo; Colombo North Teaching
   Hospital
RP Chandradasa, M (corresponding author), Univ Kelaniya, Dept Psychiat, Fac Med, Kelaniya, Sri Lanka.; Chandradasa, M (corresponding author), Colombo North Teaching Hosp, Ragama, Sri Lanka.
EM miyuruc@kln.ac.lk
RI De Berardis, Domenico/F-9343-2018; De Silva, Silumini/HMV-9858-2023;
   Chandradasa, Miyuru/R-2045-2016
OI Kuruppuarachchi, Lalith/0000-0002-8380-2329; Rathnayake,
   Layani/0000-0003-0536-9272; Chandradasa, Miyuru/0000-0002-1873-8228
CR Afshar H, 2009, J PSYCHOPHARMACOL, V23, P157, DOI 10.1177/0269881108089816
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NR 33
TC 3
Z9 4
U1 0
U2 2
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1745-6215
J9 TRIALS
JI Trials
PD SEP 20
PY 2017
VL 18
AR 435
DI 10.1186/s13063-017-2162-6
PG 8
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Research & Experimental Medicine
GA FH7HJ
UT WOS:000411355400002
PM 28931411
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Higashibata, T
   Wakai, K
   Okada, R
   Nakagawa, H
   Hamajima, N
AF Higashibata, Takahiro
   Wakai, Kenji
   Okada, Rieko
   Nakagawa, Hiroko
   Hamajima, Nobuyuki
TI Associations of smoking status with other lifestyle behaviors are
   modified by sex and occupational category among urban civil servants in
   Japan
SO ENVIRONMENTAL HEALTH AND PREVENTIVE MEDICINE
LA English
DT Article
DE Employee; Food habits; Health behavior; Lifestyle; Smoking
ID COLLABORATIVE COHORT JACC; POPULATION-BASED COHORT; LARGE-SCALE COHORT;
   CIGARETTE-SMOKING; MENTAL-HEALTH; ALCOHOL-CONSUMPTION; SLEEP
   ARCHITECTURE; METABOLIC SYNDROME; PHYSICAL-ACTIVITY; POOLED ANALYSIS
AB The aim of the present study was to examine the associations of current smoking with five other unhealthy lifestyle behaviors among urban civil servants in Japan according to sex and occupational category.
   The study included 10,232 urban civil servants in Japan who presented for a health check-up in 2011. We analyzed data on anthropometric measurements and self-reported lifestyle factors.
   Current smokers had a higher BMI than never smokers in white-collar workers, but not in blue-collar workers of both sexes. There were strong associations of current smoking with irregular breakfasting regardless of sex and occupational category. In males, current smokers were less likely to take exercise than ex-smokers in both occupational categories.
   The associations of current smoking with other unhealthy behaviors were modified by sex and occupational category. These results are useful for understanding the health risks among smokers according to sex and occupational category.
C1 [Higashibata, Takahiro; Wakai, Kenji; Okada, Rieko; Nakagawa, Hiroko] Nagoya Univ, Grad Sch Med, Dept Prevent Med, Showa Ku, 65 Tsurumai Cho, Nagoya, Aichi 4668550, Japan.
   [Nakagawa, Hiroko] Aichi Canc Ctr, Res Inst, Div Epidemiol & Prevent, Nagoya, Aichi, Japan.
   [Hamajima, Nobuyuki] Nagoya Univ, Grad Sch Med, Dept Healthcare Adm, Nagoya, Aichi, Japan.
C3 Nagoya University; Aichi Cancer Center; Nagoya University
RP Higashibata, T (corresponding author), Nagoya Univ, Grad Sch Med, Dept Prevent Med, Showa Ku, 65 Tsurumai Cho, Nagoya, Aichi 4668550, Japan.
EM hgsbata@gmail.com
RI Wakai, Kenji/I-7248-2014; Hamajima, Nobuyuki/I-7237-2014; Okada,
   Rieko/M-4989-2014
OI Okada, Rieko/0000-0002-6206-2501
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NR 39
TC 4
Z9 4
U1 0
U2 9
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1342-078X
EI 1347-4715
J9 ENVIRON HEALTH PREV
JI Environ. Health Prev.
PD NOV
PY 2016
VL 21
IS 6
BP 539
EP 546
DI 10.1007/s12199-016-0577-4
PG 8
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA EC4OO
UT WOS:000388112700018
PM 27699695
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Friedman, EM
   Montez, JK
   Sheehan, CM
   Guenewald, TL
   Seeman, TE
AF Friedman, Esther M.
   Montez, Jennifer Karas
   Sheehan, Connor McDevitt
   Guenewald, Tara L.
   Seeman, Teresa E.
TI Childhood Adversities and Adult Cardiometabolic Health: Does the
   Quantity, Timing, and Type of Adversity Matter?
SO JOURNAL OF AGING AND HEALTH
LA English
DT Article
DE life course; childhood; midlife; gender; obesity; heart disease;
   diabetes
ID EARLY-LIFE ADVERSITY; SOCIOECONOMIC-STATUS; CHRONIC-DISEASE;
   MENTAL-HEALTH; EDUCATIONAL-ATTAINMENT; RETROSPECTIVE REPORTS;
   CARDIOVASCULAR RISK; METABOLIC SYNDROME; PERSONAL CONTROL; EXPERIENCES
AB Objective: Adverse events in childhood can indelibly influence adult health. While evidence for this association has mounted, a fundamental set of questions about how to operationalize adverse events has been understudied. Method: We used data from the National Survey of Midlife Development in the United States to examine how quantity, timing, and types of adverse events in childhood are associated with adult cardiometabolic health. Results: The best-fitting specification of quantity of events was a linear measure reflecting a dose-response relationship. Timing of event mattered less than repeated exposure to events. Regarding the type of event, academic interruptions and sexual/physical abuse were most important. Adverse childhood events elevated the risk of diabetes and obesity similarly for men and women but had a greater impact on women's risk of heart disease. Discussion: Findings demonstrate the insights that can be gleaned about the early-life origins of adult health by examining operationalization of childhood exposures.
C1 [Friedman, Esther M.] RAND Corp, Santa Monica, CA 90401 USA.
   [Montez, Jennifer Karas] Syracuse Univ, Syracuse, NY USA.
   [Sheehan, Connor McDevitt] Univ Texas Austin, Austin, TX 78712 USA.
   [Guenewald, Tara L.] Univ So Calif, Los Angeles, CA USA.
   [Seeman, Teresa E.] Univ Calif Los Angeles, Los Angeles, CA USA.
C3 RAND Corporation; Syracuse University; University of Texas System;
   University of Texas Austin; University of Southern California;
   University of California System; University of California Los Angeles
RP Friedman, EM (corresponding author), RAND Corp, 1776 Main St, Santa Monica, CA 90401 USA.
EM friedman@rand.org
FU National Institute on Aging [P01-AG020166]; John D. and Catherine T.
   MacArthur Foundation Research Network on Successful Midlife Development;
   Robert Wood Johnson Foundation Health & Society Scholars Program at
   Harvard University; Eunice Kennedy Shriver National Institute of Child
   Health and Human Development [5 R24 HD042849]; UCLA CTRC grant from the
   National Institute of Health [M01-RR000865]; Older Americans
   Independence Center from the National Institute of Health [P30-AG028748]
FX The authors disclosed receipt of the following financial support for the
   research, authorship, and/or publication of this article: This research
   was supported by a grant from the National Institute on Aging
   (P01-AG020166) to conduct a longitudinal follow-up of the MIDUS (Midlife
   in the U.S.) investigation. The original study was supported by the John
   D. and Catherine T. MacArthur Foundation Research Network on Successful
   Midlife Development. Friedman and Montez were funded in part by the
   Robert Wood Johnson Foundation Health & Society Scholars Program at
   Harvard University. Sheehan was funded in part by grant 5 R24 HD042849
   (PI: Mark D. Hayward) awarded to the Population Research Center at the
   University of Texas at Austin by the Eunice Kennedy Shriver National
   Institute of Child Health and Human Development. This work was also
   funded by grants M01-RR000865 (UCLA CTRC grant, supported MIDUS data
   collection), and P30-AG028748 (Older Americans Independence Center;
   supported MIDUS data collection) from the National Institute of Health.
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NR 66
TC 122
Z9 143
U1 0
U2 28
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0898-2643
EI 1552-6887
J9 J AGING HEALTH
JI J. Aging Health
PD DEC
PY 2015
VL 27
IS 8
BP 1311
EP 1338
DI 10.1177/0898264315580122
PG 28
WC Gerontology; Health Policy & Services
WE Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Health Care Sciences & Services
GA CV6HD
UT WOS:000364370400001
PM 25903978
OA Green Submitted, Green Accepted
DA 2025-06-11
ER

PT J
AU Niknam, M
   Olazadeh, K
   Azami, M
   Boroumandieh, S
   Yari-Boroujeni, R
   Izadi, N
   Azizi, F
   Amiri, P
AF Niknam, Mahdieh
   Olazadeh, Keyvan
   Azami, Mobin
   Boroumandieh, Saeedeh
   Yari-Boroujeni, Reza
   Izadi, Neda
   Azizi, Fereidoun
   Amiri, Parisa
TI Health-related quality of life in adults with metabolic syndrome: a
   multi-level analysis of family and individual level variation
SO BMJ OPEN
LA English
DT Article
DE Quality of Life; DIABETES & ENDOCRINOLOGY; MENTAL HEALTH; PUBLIC HEALTH
ID PHYSICAL-ACTIVITY; SOCIAL SUPPORT; RISK-FACTORS; EXERCISE; ASSOCIATION;
   COMMUNITIES; DIFFERENCE; GENDER; TIME
AB Purpose The current study aimed to investigate the associations between metabolic syndrome (MetS) with health-related quality of life (HRQoL) using multilevel analysis among the Iranian adult population. Methods This cross-sectional study was conducted in the framework of the Tehran Lipid and Glucose Study (TLGS). Participants were 6113 participants (3318 women and 2795 men) aged >= 20 years of the TLGS seventh phase who had completed data on HRQoL and MetS. HRQoL was assessed using the short-form 12-item health survey V.2 and MetS defined based on the guidelines outlined in the Joint Interim Statement. The two-level model was fitted to assess the association between MetS and HRQoL. Results The prevalence of MetS and its components was higher in men, and regardless of metabolic status, men exhibited higher HRQoL values. The deleterious impact of MetS on HRQoL was more pronounced in women, while the detrimental effects of MetS on men's HRQoL were confined to specific subscales. These results were obtained through multilevel analysis, considering both familial and individual variation levels. Moreover, our investigation highlighted the positive influence of leisure-time physical activity on both the physical and mental component summaries (PCS and MCS, respectively), regardless of gender. Education had a greater positive impact on PCS in both sexes. Additionally, a history of cardiovascular diseases was associated with a decline in mental and physical HRQoL, while age was linked to a decline in PCS and MCS, and smoking was associated with a decline in MCS. Conclusion This study revealed the significant influence of gender, as well as the unique characteristics and circumstances of individuals, on the relationship between MetS and HRQoL in a general population with low/middle income.
C1 [Niknam, Mahdieh; Olazadeh, Keyvan; Yari-Boroujeni, Reza; Izadi, Neda; Amiri, Parisa] Shahid Beheshti Univ Med Sci, Res Inst Endocrine Sci, Res Ctr Social Determinants Hlth, Tehran, Iran.
   [Olazadeh, Keyvan] Shahid Beheshti Univ Med Sci, Sch Allied Med Sci, Dept Biostat, Tehran, Iran.
   [Azami, Mobin] Kurdistan Univ Med Sci, Student Res Comm, Sanandaj, Iran.
   [Boroumandieh, Saeedeh] Islamic Azad Univ, Fac Adv Sci & Technol, Dept Biotechnol, Tehran Med Sci, Tehran, Iran.
   [Azizi, Fereidoun] Shahid Beheshti Univ Med Sci, Res Inst Endocrine Sci, Endocrine Res Ctr, Tehran, Iran.
C3 Shahid Beheshti University Medical Sciences; Shahid Beheshti University
   Medical Sciences; Kurdistan University of Medical Sciences; Islamic Azad
   University; Shahid Beheshti University Medical Sciences
RP Amiri, P (corresponding author), Shahid Beheshti Univ Med Sci, Res Inst Endocrine Sci, Res Ctr Social Determinants Hlth, Tehran, Iran.
EM ma_niknam@sbmu.ac.ir; k1.olazadeh@gmail.com; mobinaz98@yahoo.com;
   saboroumand88@gmail.com; rezayari.sbmu@yahoo.com; neda.izady@yahoo.com;
   azizi@endocrine.ac.ir; amiri@endocrine.ac.ir
RI Azizi, Fereidoun/ABD-4136-2021; amiri, parisa/K-1575-2017; Azami,
   Mobin/AAE-5195-2022; Izadi, Neda/AIB-6552-2022
OI Amiri, Parisa/0000-0002-3198-4941; Niknam, Mahdieh/0000-0001-6694-204X
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NR 76
TC 1
Z9 1
U1 1
U2 1
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2044-6055
J9 BMJ OPEN
JI BMJ Open
PD NOV 18
PY 2024
VL 14
IS 11
AR e087870
DI 10.1136/bmjopen-2024-087870
PG 13
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA M8S4P
UT WOS:001360173600001
PM 39557558
OA gold
DA 2025-06-11
ER

PT J
AU Xu, H
   Yang, ZY
   Liu, DH
   Yu, CJ
   Zhao, Y
   Yang, JX
   Su, YZ
   Jiang, YH
   Lu, QA
AF Xu, Honglv
   Yang, Zhaoyu
   Liu, Dehui
   Yu, Chunjie
   Zhao, Yun
   Yang, Jiaxing
   Su, Yingzhen
   Jiang, Yinghong
   Lu, Qiuan
TI Mediating effect of physical sub-health in the association of
   sugar-sweetened beverages consumption with depressive symptoms in
   Chinese college students: A structural equation model
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Adolescents; Sugar-sweetened beverages; Depressive symptoms; Physical
   sub-health; Mediating effect
ID JUNK FOOD-CONSUMPTION; METABOLIC SYNDROME; MENTAL-HEALTH; PSYCHOLOGICAL
   SYMPTOMS; MAJOR DEPRESSION; SCHOOL-STUDENTS; DIET QUALITY; ADOLESCENTS;
   SAMPLE; RISK
AB Background: Although previous findings with small samples indicated that sugar-sweetened beverages (SSB) consumption was associated with depressive symptoms in adolescents, the mediating effect of physical subhealth in the association is unknown. Methods: A survey was conducted among freshmen from 11 provinces in China. A food frequency questionnaire was used to collect dietary behavior, and patient health questionnaire-9 items was used to assess depressive symptoms. A generalized linear model was used to analyze the association between SSB consumption, physical sub-health and depressive symptoms. The structural equation model was used to analyze the mediating effect of physical sub-health. Results: Of the 31,856 participants, 36.5 % had positive depressive symptoms. After adjusting for variables, carbonate beverages (8 = 0.11; 95%CI: 0.07-0.15; P = 0.000) and milk tea (8 = 0.07; 95%CI: 0.01-0.13; P = 0.021) consumption was associated with depressive symptoms in boys. Carbonate beverages (8 = 0.09; 95%CI: 0.05-0.13; P = 0.000), tea beverages (8 = 0.09; 95%CI: 0.04-0.13; P = 0.000), and milk tea (8 = 0.08; 95%CI: 0.04-0.11; P = 0.000) consumption was associated with depressive symptoms in girls. The mediating effect of physical sub-health accounted for 81.3 % of the total effect in the mediating model of SSB associated with depressive symptoms. Limitations: Retrospective survey has certain information bias. Association observed in the cross-sectional study is uncertain. Conclusions: The present study suggests that the consumption of SSB associated with depressive symptoms in Chinese college students, and physical sub-health plays a complete mediating role in the association.
C1 [Xu, Honglv; Yang, Zhaoyu; Yang, Jiaxing; Su, Yingzhen; Jiang, Yinghong; Lu, Qiuan] Kunming Univ, Sch Med, Puxin Rd 2, Kunming 650214, Yunnan, Peoples R China.
   [Xu, Honglv; Yang, Jiaxing; Su, Yingzhen; Jiang, Yinghong; Lu, Qiuan] Kunming Univ, Community Nursing Res Team, Kunming 650214, Yunnan, Peoples R China.
   [Yang, Zhaoyu; Liu, Dehui] Kunming Univ, Campus Hosp, Kunming 650214, Yunnan, Peoples R China.
   [Yu, Chunjie] First Peoples Hosp Kunming, Dept Pharm, Kunming 650100, Yunnan, Peoples R China.
   [Zhao, Yun] Yanan Hosp Kunming City, Dept Infect Control, Kunming 650051, Peoples R China.
C3 Kunming University; Kunming University; Kunming University
RP Xu, H (corresponding author), Kunming Univ, Sch Med, Puxin Rd 2, Kunming 650214, Yunnan, Peoples R China.; Xu, H (corresponding author), Kunming Univ, Community Nursing Res Team, Kunming 650214, Yunnan, Peoples R China.
EM x___hl@126.com
RI Li, Yuqing/AAR-9383-2021; Yang, Jiaxing/HMO-6544-2023
FU National Natural Science Foundation of China [82160622]; Introduced
   talents scientific research project of Kunming University [YJL2103]
FX This work was supported by the National Natural Science Foundation of
   China (82160622) and Introduced talents scientific research project of
   Kunming University (YJL2103) .
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NR 67
TC 5
Z9 5
U1 5
U2 40
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD DEC 1
PY 2023
VL 342
BP 157
EP 165
DI 10.1016/j.jad.2023.09.020
EA SEP 2023
PG 9
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA T7CA0
UT WOS:001079511500001
PM 37730148
DA 2025-06-11
ER

PT J
AU Tang, MM
   Cheng, SQ
   Wang, L
   Tang, H
   Liu, T
   Zhao, TY
   Dang, RL
AF Tang, Mimi
   Cheng, Shuqiao
   Wang, Lu
   Tang, Hui
   Liu, Ting
   Zhao, Tingyu
   Dang, Ruili
TI Decreased FGF19 and FGF21: possible underlying common pathogenic
   mechanism of metabolic and cognitive dysregulation in depression
SO FRONTIERS IN NEUROSCIENCE
LA English
DT Article
DE FGF19; FGF21; metabolic dysregulation; cognitive dysregulation;
   depression
ID HUMAN-MEMORY; BDNF; DISORDER; INSIGHTS; BIOLOGY; STRESS; RISK
AB BackgroundAccumulating studies suggested that major depressive disorder (MDD) was closely related to metabolic syndrome (MetS). Important endogenous regulators fibroblast growth factors (FGFs) 19 and 21 were also reported to participate in psychiatric disorders. This study aimed to investigate the role of FGF19 and FGF21 in MDD and to explore the possible pathogenic mechanism of metabolic and cognitive dysregulation in depression. MethodsA total of 59 MDD patients and 55 healthy control participants were recruited. The serum levels of FGF19 and FGF21 and lipid profiles were measured by means of enzymatic methods. Cognitive function was measured by repeatable battery for the assessment of neuropsychological status (RBANS) scores. The gene expression of PGC-1 alpha and FNDC5 was determined by quantitative polymerase chain reaction (PCR). ResultsWe found that plasma FGF19 and FGF21 levels were significantly decreased in patients with MDD. Meanwhile, triglyceride (TG) was significantly elevated and PGC-1 alpha was significantly downregulated in MDD patients. Correlation analyses showed negative associations between TG and FGF19 levels. As for cognitive performance, both FGF19 and FGF21 levels were positively correlated with immediate memory. However, FGF19 levels were negatively correlated with language, and FGF21 levels were also negatively correlated with attention and delayed memory. Additionally, negative associations were found between FGF19 levels and PGC-1 alpha. FGF21 levels were positively associated with PGC-1 alpha and negatively associated with FNDC5. ConclusionThis study elucidated the role of FGF19 and FGF21 in MDD. MDD patients were confirmed to have metabolic and cognitive dysregulation, and this abnormality was linked to the decreased concentrations of FGF19 and FGF21 through the PGC-1 alpha/FNDC5 pathway. Our results showed that the alterations of FGF19 and FGF21 levels may be a common pathogenic mechanism of metabolic and cognitive disturbances in patients with MDD.
C1 [Tang, Mimi; Cheng, Shuqiao; Liu, Ting; Zhao, Tingyu] Cent South Univ, Xiangya Hosp, Dept Pharm, Changsha, Peoples R China.
   [Tang, Mimi; Cheng, Shuqiao; Liu, Ting; Zhao, Tingyu] Cent South Univ, Xiangya Hosp, Inst Rat & Safe Medicat Pract, Natl Clin Res Ctr Geriatr Disorders, Changsha, Peoples R China.
   [Wang, Lu; Tang, Hui] Cent South Univ, Xiangya Hosp 2, Mental Hlth Inst, Changsha, Peoples R China.
   [Dang, Ruili] Jining Med Univ, Jining Peoples Hosp 1, Translat Pharmaceut Lab, Jining, Peoples R China.
C3 Central South University; Central South University; Central South
   University; Jining Medical University
RP Dang, RL (corresponding author), Jining Med Univ, Jining Peoples Hosp 1, Translat Pharmaceut Lab, Jining, Peoples R China.
EM ruilidang@mail.jnmc.edu.cn
RI Liu, Ting/JTV-4688-2023; Zhao, Tingyu/KAM-5354-2024
OI Zhao, Tingyu/0009-0000-5673-8328
FU National Natural Science Foundation of China [81803233, 81703625]; China
   Postdoctoral Science Foundation [2021M693561]; Natural Science
   Foundation of Hunan Province [2018JJ3834]; Science Foundation of Xiangya
   Hospital for Young Scholar [2017Q13]
FX This study was supported by the National Natural Science Foundation of
   China (No. 81803233 and 81703625), the fellowship of China Postdoctoral
   Science Foundation (2021M693561), the Natural Science Foundation of
   Hunan Province (No. 2018JJ3834), and the Science Foundation of Xiangya
   Hospital for Young Scholar (No. 2017Q13).
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NR 38
TC 3
Z9 3
U1 0
U2 14
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1662-453X
J9 FRONT NEUROSCI-SWITZ
JI Front. Neurosci.
PD MAY 17
PY 2023
VL 17
AR 1165443
DI 10.3389/fnins.2023.1165443
PG 8
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA H7PD9
UT WOS:000997830000001
PM 37266540
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Bai, YM
   Li, CT
   Tsai, SJ
   Tu, PC
   Chen, MH
   Su, TP
AF Bai, Ya-Mei
   Li, Cheng-Ta
   Tsai, Shih-Jen
   Tu, Pei-Chi
   Chen, Mu-Hong
   Su, Tung-Ping
TI Metabolic syndrome and adverse clinical outcomes in patients with
   bipolar disorder
SO BMC PSYCHIATRY
LA English
DT Article
DE Metabolic syndrome; Bipolar disorder; Clinical outcome
ID ADJUNCTIVE TOPIRAMATE; INSULIN-RESISTANCE; COGNITIVE FUNCTION;
   WEIGHT-GAIN; I DISORDER; OPEN-LABEL; OBESITY; BURDEN; ANTIPSYCHOTICS;
   TOLERABILITY
AB Background: Metabolic syndrome (MetS) is highly prevalent among patients with bipolar disorder. MetS may cause complications in the brain, but studies investigating MetS-associated clinical psychiatric outcomes remain scant.
   Methods: We enrolled clinically stable outpatients with bipolar disorder aged 18-65 years and performed anthropometric and fasting biochemical assessments to investigate MetS prevalence. We then performed clinical assessments by using the Young Mania Rating Scale for manic symptoms, the Montgomery-Osberg Depression Rating Scale for depressive symptoms, the Positive and Negative Symptom Scale for psychotic symptoms, the Involuntary Movement Scale for tardive dyskinesia, the Barnes Akathisia Rating Scale for akathisia, the Udvalg for Kliniske Undersogelser for general side effects, the Schedule for Assessment of Insight for insight, the Global Assessment of Functioning scale for global functioning, and the Wisconsin Card Sorting Test (WCST) for cognitive executive function.
   Results: In total, 143 patients were enrolled and had a MetS prevalence of 29.4%. The patients treated with atypical antipsychotics plus mood stabilizers (36.3%) and atypical antipsychotics alone (36.0%) had a significantly higher prevalence of MetS than did those treated with mood stabilizers alone (10.5%; p = 0.012). According to multivariate regression analyses adjusted for age, sex, smoking status, bipolar disorder subtype (I or II), pharmacological treatment duration, and psychiatric medication, compared with patients without MetS, those with MetS had significantly more previous hospitalizations (p = 0.036), severer tardive dyskinesia (p = 0.030), poorer insight (p = 0.036), poorer global function (p = 0.046), and more impaired executive function (conceptual level response on the WCST; p = 0.042).
   Conclusions: Our results indicated that patients with comorbid bipolar disorder and MetS have more adverse clinical outcomes than those without, with more hospitalizations, severer tardive dyskinesia, poorer insight, poorer global function, and more impaired executive function. Monitoring MetS is crucial for assessing not only physical burden, but also psychiatric outcomes.
C1 [Bai, Ya-Mei; Li, Cheng-Ta; Tsai, Shih-Jen; Tu, Pei-Chi; Chen, Mu-Hong; Su, Tung-Ping] Taipei Vet Gen Hosp, Dept Psychiat, Taipei, Taiwan.
   [Bai, Ya-Mei; Li, Cheng-Ta; Tsai, Shih-Jen; Tu, Pei-Chi; Chen, Mu-Hong; Su, Tung-Ping] Natl Yang Ming Univ, Dept Psychiat, Coll Med, Taipei, Taiwan.
C3 Taipei Veterans General Hospital; National Yang Ming Chiao Tung
   University
RP Bai, YM (corresponding author), Taipei Vet Gen Hosp, Dept Psychiat, Taipei, Taiwan.; Bai, YM (corresponding author), Natl Yang Ming Univ, Dept Psychiat, Coll Med, Taipei, Taiwan.
EM ymbi@mail2000.com.tw
RI Chen, MuHong/ACJ-6131-2022; Li, Cheng-Ta/AAI-5759-2021; Tsai,
   Shih-Jen/AAK-7944-2020
OI Li, Cheng-Ta/0000-0002-0670-1153
FU Taiwan Ministry of Science and Technology [MOST 104-2314-B-075-017];
   Taipei Veterans General Hospital [V103E9-005, V103E3-006]
FX The study was supported by grants from the Taiwan Ministry of Science
   and Technology (MOST 104-2314-B-075-017), and Taipei Veterans General
   Hospital (V103E9-005, V103E3-006). These funding resources are
   independent of the study.
CR [Anonymous], FAT CHANCE SLIM NONE
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NR 49
TC 38
Z9 41
U1 0
U2 8
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-244X
J9 BMC PSYCHIATRY
JI BMC Psychiatry
PD DEC 15
PY 2016
VL 16
AR 448
DI 10.1186/s12888-016-1143-8
PG 9
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA EF5TE
UT WOS:000390391700001
PM 27978821
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Grienke, U
   Kaserer, T
   Pfluger, F
   Mair, CE
   Langer, T
   Schuster, D
   Rollinger, JM
AF Grienke, Ulrike
   Kaserer, Teresa
   Pfluger, Florian
   Mair, Christina E.
   Langer, Thierry
   Schuster, Daniela
   Rollinger, Judith M.
TI Accessing biological actions of Ganoderma secondary metabolites
   by in silico profiling
SO PHYTOCHEMISTRY
LA English
DT Article
DE Ganoderma lucidum; Ganodermataceae; Pharmacophore profiling; Virtual
   screening; Triterpenes; Antiviral targets; Metabolic syndrome
ID PHARMACOPHORE-BASED DISCOVERY; ALDOSE REDUCTASE; FRUITING BODIES;
   MINERALOCORTICOID RECEPTOR; ADIPOCYTE DIFFERENTIATION; CONFORMER
   GENERATION; INHIBITORY-ACTIVITY; OXIDATIVE STRESS; HIGH-THROUGHPUT;
   LUCIDUM
AB The species complex around the medicinal fungus Ganoderma lucidum Karst. (Ganodermataceae) is widely known in traditional medicines, as well as in modern applications such as functional food or nutraceuticals. A considerable number of publications reflects its abundance and variety in biological actions either provoked by primary metabolites, such as polysaccharides, or secondary metabolites, such as lanostane-type triterpenes. However, due to this remarkable amount of information, a rationalization of the individual Ganoderma constituents to biological actions on a molecular level is quite challenging. To overcome this issue, a database was generated containing meta-information, i.e., chemical structures and biological actions of hitherto identified Ganoderma constituents (279). This was followed by a computational approach subjecting this 3D multi-conformational molecular dataset to in silica parallel screening against an in-house collection of validated structure- and ligand-based 3D pharmacophore models. The predictive power of the evaluated in silica tools and hints from traditional application fields served as criteria for the model selection. Thus, the focus was laid on representative druggable targets in the field of viral infections (5) and diseases related to the metabolic syndrome (22). The results obtained from this in silico approach were compared to bioactivity data available from the literature. 89 and 197 Ganoderma compounds were predicted as ligands of at least one of the selected pharmacological targets in the antiviral and the metabolic syndrome screening, respectively. Among them only a minority of individual compounds (around 10%) has ever been investigated on these targets or for the associated biological activity. Accordingly, this study discloses putative ligand target interactions for a plethora of Ganoderma constituents in the empirically manifested field of viral diseases and metabolic syndrome which serve as a basis for future applications to access yet undiscovered biological actions of Ganoderma secondary metabolites on a molecular level. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Grienke, Ulrike; Mair, Christina E.; Rollinger, Judith M.] Univ Innsbruck, Inst Pharm Pharmacognosy, A-6020 Innsbruck, Austria.
   [Grienke, Ulrike; Mair, Christina E.; Rollinger, Judith M.] Univ Innsbruck, Ctr Mol Biosci Innsbruck, A-6020 Innsbruck, Austria.
   [Kaserer, Teresa; Pfluger, Florian; Schuster, Daniela] Univ Innsbruck, Inst Pharm Pharmacognosy Chem, Comp Aided Mol Design Grp, Ctr Mol Biosci Innsbruck, A-6020 Innsbruck, Austria.
   [Langer, Thierry] Univ Vienna, Fac Life Sci, Dept Pharmaceut Chem, A-1090 Vienna, Austria.
   [Rollinger, Judith M.] Univ Vienna, Fac Life Sci, Dept Pharmacognosy, A-1090 Vienna, Austria.
C3 University of Innsbruck; University of Innsbruck; University of
   Innsbruck; University of Vienna; University of Vienna
RP Grienke, U (corresponding author), Univ Innsbruck, Inst Pharm Pharmacognosy, Innrain 80-82, A-6020 Innsbruck, Austria.
EM ulrike.grienke@uibk.ac.at
RI Rollinger, Judith/Q-5996-2019; Grienke, Ulrike/H-2585-2017; Schuster,
   Daniela/C-1024-2014; Langer, Thierry/U-8621-2017
OI Kaserer, Teresa/0000-0003-0372-1885; Grienke,
   Ulrike/0000-0003-0305-9270; Rollinger, Judith/0000-0001-6581-0774;
   Schuster, Daniela/0000-0002-9933-8938; Langer,
   Thierry/0000-0002-5242-1240
FU Austrian Science Fund [FWF: P24587]; foundation "Verein zur Forderung
   der wissenschaftlichen Ausbildung und Tatigkeit von Sudtirolern an der
   Landesuniversitat Innsbruck"; Austrian Science Fund (FWF) [P24587]
   Funding Source: Austrian Science Fund (FWF)
FX U.G. and C.E.M. are grateful for their positions funded by the Austrian
   Science Fund (FWF: P24587). T.K. was supported by the foundation "Verein
   zur Forderung der wissenschaftlichen Ausbildung und Tatigkeit von
   Sudtirolern an der Landesuniversitat Innsbruck". D.S. thanks the
   University for her position within the Erika Cremer Habilitation
   Program. We thank OpenEye and Inte:Ligand for providing their software
   under special academic Grant agreements free of charge.
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NR 94
TC 30
Z9 32
U1 0
U2 34
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0031-9422
J9 PHYTOCHEMISTRY
JI Phytochemistry
PD JUN
PY 2015
VL 114
SI SI
BP 114
EP 124
DI 10.1016/j.phytochem.2014.10.010
PG 11
WC Biochemistry & Molecular Biology; Plant Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Plant Sciences
GA CK9HS
UT WOS:000356551800010
PM 25457486
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Rosenson, RS
   Huskin, AL
   Wolff, DA
   Helenowski, IB
   Rademaker, AW
AF Rosenson, Robert S.
   Huskin, Anna L.
   Wolff, David A.
   Helenowski, Irene B.
   Rademaker, Alfred W.
TI Fenofibrate reduces fasting and postprandial inflammatory responses
   among hypertriglyceridemia patients with the metabolic syndrome
SO ATHEROSCLEROSIS
LA English
DT Article
DE cytokines; oxidative stress; very low-density lipoprotein;
   hypertriglyceridemia; metabolic syndrome
ID PPAR-ALPHA ACTIVATORS; C-REACTIVE PROTEIN; KAPPA-B; COMBINED
   HYPERLIPIDEMIA; LIPID-PEROXIDATION; RISK; MARKERS; LIPOPROTEINS;
   DENSITY; SUSCEPTIBILITY
AB Objective: To examine the effects of fenofibrate ( 160 mg/d) therapy on fasting and postprandial cytokine production in subjects with metabolic syndrome and hypertriglyceridemia.
   Research design and methods: Randomized, double-blind, controlled trial that compared the effects of 3-month therapy with placebo and fenolibrate on fasting and postprandial cytokine production in 55 subjects with metabolic syndrome and elevated fasting triglycerides (>= 1.7 and <6.78 mmol/L).
   Results: Fenofibrate treatment reduced concentrations of monohydroxy fatty acids (OH-FA) by 15.5% (p = 0.001), lipopolysaccharide activated monocyte chemotactic protein-1 (MCP-1/CCL2) production in fasting blood samples by 3.4% (p=0.01 vs. placebo), macrophage inflammatory protein-1 alpha (MIP-1 alpha/CCU) by 3.5% (p=0.01), and interleukin-1 beta (IL-1 beta) by 2.5% (p=0.04). After a standardized fat load (50kg/m(2)), OH-FA were reduced by 31.0% (p <0.0001), MCP-1/CCL2 was reduced by 5.2% (p=0.002), MIP-1 alpha/CCL3 by 3.9% (p=0.007), and IL-I beta by 3.4% (p=0.02). Reductions in MCP-1/CCL2, MIP-1 alpha/CCL3, and IL-1 beta production correlated with changes in fasting and postprandial large very low-density lipoprotein (VLDL) (all p < 0.005) and small low-density lipoprotein (LDL) particles (all p < 0.05). In stepwise regression models that included age, gender, weight change, and drug assignment, large VLDL particles were associated with reductions in postprandial MCP-1/CCL2 (p = 0.042), MIP-1 alpha/CCL3 (p = 0.003), and IL-1 beta (p = 0.02).
   Conclusions: This study reports that fenofibrate reduces whole blood production of inflammatory cytokines and hepatic-synthesized inflammatory proteins, and the anti-inflammatory effects of fenofibrate therapy involve VLDL- and LDL-mediated pathways. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
C1 [Rosenson, Robert S.] Univ Michigan, Div Cardiovasc Med, Ann Arbor, MI 48106 USA.
   [Huskin, Anna L.; Wolff, David A.] Northwestern Univ, Feinberg Sch Med, Div Cardiol, Lipoprotein & Hemorheol Res Facil, Chicago, IL 60611 USA.
   [Helenowski, Irene B.; Rademaker, Alfred W.] Northwestern Univ, Feinberg Sch Med, Dept Prevent Med, Chicago, IL 60611 USA.
C3 University of Michigan System; University of Michigan; Northwestern
   University; Feinberg School of Medicine; Northwestern University;
   Feinberg School of Medicine
RP Rosenson, RS (corresponding author), Univ Michigan, Div Cardiovasc Med, 24 Frank Lloyd Wright Drive, Ann Arbor, MI 48106 USA.
EM rrosenso@umich.edu
RI Rosenson, Robert/MDS-6957-2025
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NR 28
TC 27
Z9 28
U1 0
U2 3
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0021-9150
EI 1879-1484
J9 ATHEROSCLEROSIS
JI Atherosclerosis
PD JUN
PY 2008
VL 198
IS 2
BP 381
EP 388
DI 10.1016/j.atherosclerosis.2007.12.007
PG 8
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 319AH
UT WOS:000257133600019
PM 18242616
DA 2025-06-11
ER

PT J
AU Bedi, N
   Dwivedi, D
   Kaur, N
   Chamola, S
   Tripathi, S
   Abrol, P
AF Bedi, Nidhi
   Dwivedi, Deepti
   Kaur, Nimarpreet
   Chamola, Sunil
   Tripathi, Saurabh
   Abrol, Pankaj
TI Effect of Educational Intervention as Cognitive Behavioural Therapy for
   Intake of Junk Food, Sugar-sweetened Beverages and Energy Drinks among
   Medical Students from India: A Prospective Interventional Study
SO JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH
LA English
DT Article
DE Communicable disease; Health education; Metabolic syndrome
ID METABOLIC SYNDROME; OBESITY; GUIDELINES; OVERWEIGHT; IMPACT
AB Introduction: Junk food intake has increased many folds in the last two decades. India is still struggling with communicable diseases, though the incidence of non communicable diseases, including metabolic syndrome, has increased several times in the younger age group. There is a scarcity of data and a limited number of international studies on decreasing junk food intake, especially in India. Aim: To assess eating habits, nutritional status, and the effect of behavioural therapy on junk food intake in medical undergraduate students. Materials and Methods: A prospective interventional study was conducted in medical students of a tertiary care hospital in Northern India (Faculty of Medicine and Health Sciences, SGT University, Haryana, India) over a duration of six months, from October 2021 to March 2022. All students were given a pretest in the form of an electronic questionnaire. Students then received four educational sessions based on Cognitive Behavioural Therapy (CBT), one session per week, each lasting 30 minutes. At the end of the four sessions, all students were assessed through a post-test following the same protocol as the pretest. Statistical analysis was conducted using Statistical Packages for Social Sciences (SPSS) version 28.0 The Wilcoxon's signed-rank test was applied for comparison within pre and post-interventions. Results: Most of the students, 302 (68%), included in the study were less than 20 years of age, with a minimum age of 17 years and a maximum age of 25 years. A total of 443 students were included in the study. Of these, 178 out of 443 had a Body Mass Index (BMI)>25 kg/m(2) , classifying them as overweight (40.18%). The majority of students were not aware of the major side effects of junk food intake, but a significant improvement was noted in the post-test conducted four weeks later. A significant change (p<0.0001) was observed in the frequency of intake of junk food, sugar -sweetened beverages, and energy drinks, decreasing significantly after the four educational sessions. Conclusion: Short educational intervention programs, as part of cognitive -behavioural theory, have a significant impact on improving awareness and reducing the intake of junk food. More studies of longer duration and involving other components of CBT should be conducted to assess their impact on physical and mental health.
C1 [Bedi, Nidhi; Abrol, Pankaj] Fac Med & Hlth Sci, Dept Paediat, Gurugram, Haryana, India.
   [Dwivedi, Deepti; Kaur, Nimarpreet] Fac Med & Hlth Sci, Dept Physiol, Gurugram, Haryana, India.
   [Chamola, Sunil; Tripathi, Saurabh] Fac Med & Hlth Sci, Dept Community Med, Gurugram, Haryana, India.
RP Dwivedi, D (corresponding author), A2-301 Unitech Residences,Sect 33, Gurugram 122001, Haryana, India.
EM deeptidwd86@gmail.com
RI Abrol, Pankaj/AAK-6376-2021
CR Ashakiran, 2012, J KRISHNA INST MED S, V1, P7
   Bairwa Mohan, 2013, Indian J Community Med, V38, P185, DOI 10.4103/0970-0218.116358
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   Bhushan C., 2017, Burden of packaged food on schoolchildren: Based on the CSE survey know your diet
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NR 19
TC 0
Z9 0
U1 2
U2 5
PU PREMCHAND SHANTIDEVI RESEARCH FOUNDATION
PI DELHI
PA 71 JAIN COLONY, VEER NAGAR, DELHI, 110 007, INDIA
SN 2249-782X
EI 0973-709X
J9 J CLIN DIAGN RES
JI J. Clin. Diagn. Res.
PD MAY
PY 2024
VL 18
IS 5
BP OC1
EP OC6
DI 10.7860/JCDR/2024/66955.19342
PG 6
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA QS4W8
UT WOS:001222857200054
OA gold
DA 2025-06-11
ER

PT J
AU Polovina, M
   Dikic, D
   Vlajkovic, A
   Viotijevic, M
   Milinkovic, I
   Asanin, M
   Ostojic, M
   Coats, AJS
   Seferovic, PM
AF Polovina, Marija
   Dikic, Dijana
   Vlajkovic, Ana
   Viotijevic, Matej
   Milinkovic, Ivan
   Asanin, Milika
   Ostojic, Miodrag
   Coats, Andrew J. S.
   Seferovic, Petar M.
TI Adverse cardiovascular outcomes in atrial fibrillation: Validation of
   the new 2MACE risk score
SO INTERNATIONAL JOURNAL OF CARDIOLOGY
LA English
DT Article
DE Atrial fibrillation; Major adverse cardiovascular event; Risk score;
   Metabolic syndrome; Myocardial infarction; Cardiac death
ID ACUTE MYOCARDIAL-INFARCTION; HEART-FAILURE; HYPERTENSIVE PATIENTS;
   ATHEROSCLEROSIS RISK; METABOLIC SYNDROME; CLINICAL-FEATURES; CORONARY;
   PREVALENCE; MANAGEMENT; MORTALITY
AB Background: In addition to thromboembolism, atrial fibrillation (AF) may also predispose to major adverse cardiovascular events (MACE) attributable to coronary artery disease (CAD), including myocardial infarction (MI). The 2MACE score (2 points -Metabolic syndrome and Age >= 75 years, 1 point - MI/revascularization, Congestive heart failure/ejection-fraction <40%, and thrombo-Embolism) was recently proposed to help identify AF patients at risk of MACE. We assessed the predictive validity of the 2MACE score for MACE occurrence in AF patients free of CAD at baseline.
   Methods: Non-valvular AF patients (n = 794) without CAD (mean-age, 62.5 +/- 12.1 years, metabolic syndrome, 34.0%; heart failure/ejection-fraction <40%, 25.7%; thromboembolism, 9.7%) were prospectively followed for 5 years, or until MACE (composite of non-fatal/fatal MI, revascularization and cardiovascular death). At inclusion, CAD was excluded by medical history, exercise-stress testing and/or coronary angiography. Also, the 2MACE score was determined.
   Results: At follow-up, 112 patients experienced MACE (2.8%/year). The 2MACE score demonstrated adequate discrimination (C-statistic, 0.699; 95% confidence interval [CI], 0.648-0.750; P < 0.001) and calibration (Hosmer-Lemeshow P = 0.79) for MACE. The score was significantly associated with MACE, with the adjusted Hazard Ratio (aHR) of 1.56 (95% CI, 1.35-1.73; P < 0.001). As for individual outcomes, the score predicted MI (n = 46; aHR, 1.49; 95% CI 1.23-1.80), revascularization (n = 32; aHR, 1.41; 95% CI, 1.11-1.80) and cardiovascular death (n = 34; aHR, 1.43; 95% CI, 1.14-1.81), all P < 0.001.
   Conclusions: The 2MACE score successfully predicts future MACE, including incident MI, coronary revascularization and cardiovascular death in AF patients free of CAD at baseline. It may have a role in risk-stratification and primary prevention of MACE in AF patients. (C) 2017 Elsevier B.V. All rights reserved.
C1 [Polovina, Marija; Dikic, Dijana; Milinkovic, Ivan; Asanin, Milika; Seferovic, Petar M.] Clin Ctr Serbia, Dept Cardiol, 26 Visegradska, Belgrade 11000, Serbia.
   [Polovina, Marija; Vlajkovic, Ana; Viotijevic, Matej; Asanin, Milika; Ostojic, Miodrag; Seferovic, Petar M.] Univ Belgrade, Sch Med, 8 Doktora Subotica, Belgrade 11000, Serbia.
   [Coats, Andrew J. S.] San Raffaele Pisana Sci Inst, Via Pisana 235, I-00163 Rome, Italy.
C3 Clinical Centre of Serbia; University of Belgrade; IRCCS San Raffaele
   Pisana
RP Seferovic, PM (corresponding author), Clin Ctr Serbia, Dept Cardiol, 26 Visegradska, Belgrade 11000, Serbia.
EM seferovic.petar@gmail.com
RI Povzun, Anton/Q-1460-2016; Coats, Andrew/E-4451-2012
OI Polovina, Marija/0000-0001-9589-0023
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NR 49
TC 22
Z9 22
U1 0
U2 12
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0167-5273
EI 1874-1754
J9 INT J CARDIOL
JI Int. J. Cardiol.
PD DEC 15
PY 2017
VL 249
BP 191
EP 197
DI 10.1016/j.ijcard.2017.09.154
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA FL5ZZ
UT WOS:000414326300039
PM 28986061
DA 2025-06-11
ER

PT J
AU Madani, Z
   Louchami, K
   Sener, A
   Malaisse, WJ
   Yahia, DA
AF Madani, Zohra
   Louchami, Karim
   Sener, Abdullah
   Malaisse, Willy J.
   Yahia, Dalila Ait
TI Dietary sardine protein lowers insulin resistance, leptin and TNF-α and
   beneficially affects adipose tissue oxidative stress in rats with
   fructose-induced metabolic syndrome
SO INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
LA English
DT Article
DE metabolic syndrome; fructose; sardine protein; rats
ID C-REACTIVE PROTEIN; NECROSIS-FACTOR-ALPHA; FREE FATTY-ACIDS; COD
   PROTEIN; SKELETAL-MUSCLE; FISH CONSUMPTION; GLUCOSE; RISK; MEN;
   SENSITIVITY
AB The present study aims at exploring the effects of sardine protein on insulin resistance, plasma lipid profile, as well as oxidative and inflammatory status in rats with fructose-induced metabolic syndrome. Rats were fed sardine protein (S) or casein (C) diets supplemented or not with high-fructose (HF) for 2 months. Rats fed the HF diets had greater body weight and adiposity and lower food intake as compared to control rats. Increased plasma glucose, insulin, HbA1C, triacylglycerols, free fatty acids and impaired glucose tolerance and insulin resistance was observed in HF-fed rats. Moreover, a decline in adipose tissues antioxidant status and a rise in lipid peroxidation and plasma TNF-alpha and fibrinogen were noted. Rats fed sardine protein diets exhibited lower food intake and fat mass than those fed casein diets. Sardine protein diets diminished plasma insulin and insulin resistance. Plasma triacylglyeerol and free fatty acids were also lower, while those of a-tocopherol, taurine and calcium were enhanced as compared to casein diets. Moreover, S-HF diet significantly decreased plasma glucose and HbA1C. Sardine protein consumption lowered hydroperoxide levels in pen renal and brown adipose tissues. The S-HF diet, as compared to C-HF diet decreased epididymal hydroperoxides. Feeding sardine protein diets decreased brown adipose tissue carbonyls and increased glutathione peroxidase activity. Perirenal and epididymal superoxide dismutase and catalase activities and brown catalase activity were significantly greater in S-HF group than in C-HF group. Sardine protein diets also prevented hyperleptinemia and reduced inflammatory status in comparison with rats fed casein diets. Taken together, these results support the beneficial effect of sardine protein in fructose-induced metabolic syndrome on such variables as hyperglycemia, insulin resistance, hyperlipidemia and oxidative and inflammatory status, suggesting the possible use of sardine protein as a protective strategy against insulin resistance and related situations.
C1 [Louchami, Karim; Sener, Abdullah; Malaisse, Willy J.] Univ Libre Bruxelles, Lab Expt Hormonol, B-1070 Brussels, Belgium.
   [Madani, Zohra; Yahia, Dalila Ait] Es Senia Univ, Dept Biol, Oran, Algeria.
C3 Universite Libre de Bruxelles; Universite d'Oran
RP Malaisse, WJ (corresponding author), Univ Libre Bruxelles, Lab Expt Hormonol, 808 Route Lennik, B-1070 Brussels, Belgium.
EM malaisse@ulb.ac.be
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NR 48
TC 65
Z9 73
U1 0
U2 15
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1107-3756
EI 1791-244X
J9 INT J MOL MED
JI Int. J. Mol. Med.
PD FEB
PY 2012
VL 29
IS 2
BP 311
EP 318
PG 8
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 872QQ
UT WOS:000298824800027
PM 22085913
OA Bronze
DA 2025-06-11
ER

PT J
AU Papazoglou, K
   Tuttle, BM
AF Papazoglou, Konstantinos
   Tuttle, Brooke McQuerrey
TI Fighting Police Trauma: Practical Approaches to Addressing Psychological
   Needs of Officers
SO SAGE OPEN
LA English
DT Article
DE police trauma; police stress; psychological support; clinical
   intervention; police health promotion; police psychological well-being;
   police job performance
ID HOME-VISIT INTERVENTION; LAW-ENFORCEMENT; POSTTRAUMATIC-STRESS;
   OCCUPATIONAL STRESS; METABOLIC SYNDROME; JOB STRESS; WORK; RESILIENCE;
   STRATEGIES; INCIDENTS
AB Stress and trauma experienced by police officers in the line of duty can have negative impacts on officers' health and well-being. Psychological support is imperative to help officers maintain psychological well-being and to perform their duties efficiently. However, officers are often skeptical to seek psychological support. The reasons behind such skepticism vary. Specifically, officers may believe that clinicians do not understand police work. In addition, inquiries by clinicians into personal and early life experiences may be interpreted as attempts to patronize officers; as a result, police officers' identities as those who serve and protect may be disparaged in the context of therapy. This article recommends a number of evidence and practice-based actions that clinicians may employ to approach police culture and develop effective clinical support for officers who suffer from the debilitating effects of police-related stress and trauma. Recommendations for empirical research and clinical practice are discussed.
C1 [Papazoglou, Konstantinos] Ontario Minist Community Safety & Correct Serv, Justice Sect, 109 McLaughlin Rd S, Brampton, ON L6Y 2C8, Canada.
   [Papazoglou, Konstantinos] Univ Toronto, Dept Psychol, Mississauga Campus, Mississauga, ON, Canada.
   [Tuttle, Brooke McQuerrey] Oklahoma State Univ, Ctr Family Resilience, Tulsa, OK USA.
C3 University of Toronto; University Toronto Mississauga
RP Papazoglou, K (corresponding author), Ontario Minist Community Safety & Correct Serv, Justice Sect, 109 McLaughlin Rd S, Brampton, ON L6Y 2C8, Canada.
EM konstantinos.papazoglou@ontario.ca
RI Papazoglou, Konstantinos/Y-3587-2019
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NR 76
TC 39
Z9 75
U1 1
U2 19
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 2158-2440
J9 SAGE OPEN
JI SAGE Open
PD AUG 22
PY 2018
VL 8
IS 3
AR 2158244018794794
DI 10.1177/2158244018794794
PG 11
WC Social Sciences, Interdisciplinary
WE Social Science Citation Index (SSCI)
SC Social Sciences - Other Topics
GA GR3WD
UT WOS:000442527000001
OA gold
DA 2025-06-11
ER

PT J
AU Naz, MSG
   Noroozzadeh, M
   Ardebili, SN
   Mousavi, M
   Azizi, F
   Tehrani, FR
AF Naz, Marzieh Saei Ghare
   Noroozzadeh, Mahsa
   Ardebili, Shahla Noori
   Mousavi, Maryam
   Azizi, Fereidoun
   Tehrani, Fahimeh Ramezani
TI Cardio-Metabolic Risk Profile of Women With Endometriosis: A
   Population-Based Study
SO ENDOCRINOLOGY DIABETES & METABOLISM
LA English
DT Article
DE diabetes; endometriosis; hypertension; metabolic syndrome; Tehran Lipid
   and Glucose Study
ID CORONARY-HEART-DISEASE; PERITONEAL-FLUID; CHOLESTEROL; INFLAMMATION;
   SERUM; EPIDEMIOLOGY; PREDICTION; PROTEINS; MARKERS; STRESS
AB Aims: Endometriosis (EM) and metabolic disorders are frequent health problems among reproductive-aged women worldwide. Cardio-metabolic risk profile of women with EM is not well understood. We aimed to investigate the cardio-metabolic risk profile of Iranian reproductive-aged women with EM. Methods: This study included 976 female participants aged 20-45 years of Tehran Lipid and Glucose Study. Endometriosis was diagnosed based on the participants' self-reported previous diagnosis of EM, which was confirmed by reviewing the relevant medical documentation. All biochemical measures (low-density lipoprotein cholesterol [LDL], high-density lipoprotein cholesterol [HDL], triglycerides [TG], and fasting blood glucose concentrations [FBG]) and measurement of systolic blood pressure (SBP) and diastolic blood pressure (DBP) and anthropometric parameters were performed according to the standard protocol of TLGS. Logistic regression analysis was performed to estimate the odds ratio of cardio-metabolic disease. Results: Of the 976 study participants, 161 individuals (16.5%) had a confirmed diagnosis of endometriosis. There were no significant differences in the median of metabolic parameters among women with and without endometriosis (p > 0.05). The prevalence of metabolic syndrome was significantly higher in women with EM group compared to the non-EM group (21.9% vs. 14.9%). The presence of endometriosis was associated with an increased odds of metabolic syndrome (adjusted odds ratio 1.99 [95% CI 1.20-3.30]; p = 0.007). And endometriosis significantly increased odds of low HDL by 2.07 (1.02-4.20); after adjustment, it still remained significant (p = 0.03). Endometriosis also increased odds of high waist circumstance significantly (1.58 [1.06-2.37]; p = 0.02). Conclusions: Women with endometriosis may be at an increased risk of developing metabolic syndrome, high waist circumstance and low HDL compared to their counterparts without the condition. Given the potential cardio-metabolic implications, healthcare providers should consider assessing the metabolic profile of women diagnosed with endometriosis.
C1 [Naz, Marzieh Saei Ghare; Noroozzadeh, Mahsa; Ardebili, Shahla Noori; Mousavi, Maryam; Tehrani, Fahimeh Ramezani] Shahid Beheshti Univ Med Sci, Res Inst Endocrine Sci, Reprod Endocrinol Res Ctr, Tehran, Iran.
   [Azizi, Fereidoun] Shahid Beheshti Univ Med Sci, Res Inst Endocrine Sci, Endocrine Res Ctr, Tehran, Iran.
   [Tehrani, Fahimeh Ramezani] Fdn Res & Educ Excellence, Vestavia Hills, AL 35266 USA.
C3 Shahid Beheshti University Medical Sciences; Shahid Beheshti University
   Medical Sciences
RP Tehrani, FR (corresponding author), Shahid Beheshti Univ Med Sci, Res Inst Endocrine Sci, Reprod Endocrinol Res Ctr, Tehran, Iran.; Tehrani, FR (corresponding author), Fdn Res & Educ Excellence, Vestavia Hills, AL 35266 USA.
EM fah.tehrani@gmail.com
RI Azizi, Fereidoun/ABD-4136-2021; Noroozzadeh, Mahsa/K-4765-2017; Mousavi,
   Maryam/ACO-9731-2022; Tehrani, Fahimeh/H-6133-2017; Naz,
   Marzieh/K-8811-2019
OI Ramezani Tehrani, Fahimeh/0000-0002-4609-065X; Saei Ghare Naz,
   Marzieh/0000-0002-1259-2459
FU Research Institute for Endocrine Sciences, Shahid Beheshti University of
   Medical Sciences, Tehran, Iran [6-43011614]
FX This study funded by the Research Institute for Endocrine Sciences,
   Shahid Beheshti University of Medical Sciences, Tehran, Iran (Grant
   number: 6-43011614)
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NR 69
TC 1
Z9 1
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
EI 2398-9238
J9 ENDOCRIN DIAB METAB
JI Endocrinol. Diabetes Metab.
PD NOV
PY 2024
VL 7
IS 6
AR e70008
DI 10.1002/edm2.70008
PG 8
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA J0K3N
UT WOS:001334043800001
PM 39400459
OA gold
DA 2025-06-11
ER

PT J
AU Lejman-Larysz, K
   Golara, A
   Baranowska, M
   Kozlowski, M
   Guzik, P
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   Sowinska-Przepiera, E
   Cymbaluk-Ploska, A
   Brodowska, A
AF Lejman-Larysz, Katarzyna
   Golara, Anna
   Baranowska, Marta
   Kozlowski, Mateusz
   Guzik, Pawel
   Szydlowska, Iwona
   Nawrocka-Rutkowska, Jolanta
   Sowinska-Przepiera, Elzbieta
   Cymbaluk-Ploska, Aneta
   Brodowska, Agnieszka
TI Influence of Vitamin D on the Incidence of Metabolic Syndrome and
   Hormonal Balance in Patients with Polycystic Ovary Syndrome
SO NUTRIENTS
LA English
DT Article
DE vitamin D; polycystic ovary syndrome; metabolic syndrome;
   sex-hormone-binding globulin; prolactin; thyroid-stimulating hormone;
   androstendione; dehydroepiandrosterone sulfate; follicle-stimulating
   hormone; luteinizing hormone
ID 25-HYDROXYVITAMIN D LEVEL; D SUPPLEMENTATION; OXIDATIVE STRESS;
   INSULIN-RESISTANCE; HYPOVITAMINOSIS D; WOMEN; METAANALYSIS;
   INFLAMMATION; SENSITIVITY; ASSOCIATION
AB Polycystic ovary syndrome (PCOS) is a heterogeneous endocrine disorder that affects 8-13% of women of reproductive age. It is one of the most common causes of infertility and is associated with hyperandrogenism in the form of hirsutism and acne, non-ovulatory cycles, and characteristic ovarian morphology. The available research on serum vitamin D deficiency in patients with PCOS and the appropriateness of vitamin D supplementation in this group of women is inconclusive, so we decided to investigate the influence of vitamin D on the incidence of metabolic syndrome and hormonal balance in patients with polycystic ovary syndrome. The study comprised 120 women aged between 18 and 42 years, who were divided into two groups: a group with diagnosed polycystic ovary syndrome (PCOS) and a group of regularly menstruating women without features of androgenisation, in whom polycystic ovary syndrome was excluded. Each patient underwent a history and physical examination, including a gynecological examination, anthropometric measurements were taken, including height, weight, waist, and hip circumference, and blood pressure was measured using the Korotkow method. In the female patients, the following parameters were also determined from the blood: follicle-stimulating hormone (FSH), luteinizing hormone (LH), oestradiol, TSH, ft4, prolactin (PRL), total testosterone, DHEASO4, 17-hydroxyprogesterone (17-OHP), sex-hormone-binding globulin (SHBG), androstendione, 25(OH) vitamin D3 metabolite. The majority of the patients with polycystic ovary syndrome were found to have deficient or suboptimal serum vitamin D levels, and the effects of vitamin D on the SHBG levels and free-androgen indices in these patients was examined. The effects of vitamin D on the incidence of metabolic syndrome and BMI, waist-to-hip ratio, waist circumference, and blood pressure in patients with polycystic ovary syndrome were also found.
C1 [Lejman-Larysz, Katarzyna; Szydlowska, Iwona; Nawrocka-Rutkowska, Jolanta; Brodowska, Agnieszka] Pomeranian Med Univ, Dept Gynecol Endocrinol & Gynecol Oncol, Unii Lubelskiej 1, PL-71252 Szczecin, Poland.
   [Golara, Anna; Baranowska, Marta; Kozlowski, Mateusz; Cymbaluk-Ploska, Aneta] Pomeranian Med Univ, Dept Reconstruct Surg & Gynecol Oncol, Al Powstancow Wielkopolskich 72, PL-70111 Szczecin, Poland.
   [Guzik, Pawel] City Hosp, Clin Dept Gynecol & Obstet, PL-35241 Rzeszow, Poland.
   [Sowinska-Przepiera, Elzbieta] Pomeranian Med Univ, Dept Endocrinol Metab & Internal Dis, Unii Lubelskiej 1, PL-71252 Szczecin, Poland.
C3 Pomeranian Medical University; Pomeranian Medical University; Pomeranian
   Medical University
RP Golara, A (corresponding author), Pomeranian Med Univ, Dept Reconstruct Surg & Gynecol Oncol, Al Powstancow Wielkopolskich 72, PL-70111 Szczecin, Poland.
EM kmlejman@gmail.com; anka39143@gmail.com; marciabaranowska2211@gmail.com;
   mtkoozo@gmail.com; pawelguzik@gmail.com; iwonaszyd@wp.pl;
   jolanaw@poczta.onet.pl; elzbieta.sowinska.przepiera@pum.edu.pl;
   aneta.cymbaluk@gmail.com; agabrod@wp.pl
RI Kozłowski, Mateusz/GLN-7723-2022; Agnieszka, Brodowska/B-1622-2018;
   Szydłowska, Iwona/AAA-6713-2022; Sowinska-Przepiera,
   Elzbieta/A-3367-2015
OI Nawrocka-Rutkowska, Jolanta/0000-0002-1631-152X; Golara,
   Anna/0000-0003-4300-4557; Brodowska, Agnieszka/0000-0002-6425-1648;
   Sowinska-Przepiera, Elzbieta/0000-0001-6693-9465; Kozlowski,
   Mateusz/0000-0002-1176-2153; Szydlowska, Iwona/0000-0003-1518-8838
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NR 26
TC 8
Z9 8
U1 3
U2 10
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JUL
PY 2023
VL 15
IS 13
AR 2952
DI 10.3390/nu15132952
PG 13
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA M2FA8
UT WOS:001028379700001
PM 37447279
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Hristova, M
   Aloe, L
AF Hristova, M
   Aloe, L
TI Metabolic syndrome - Neurotrophic hypothesis
SO MEDICAL HYPOTHESES
LA English
DT Article
ID NERVE GROWTH-FACTOR; PITUITARY-ADRENAL AXIS; INSULIN-RESISTANCE;
   BLOOD-PRESSURE; BRAIN; BEHAVIOR; OBESITY; LEPTIN; GLAND
AB An increasing number of researchers of the metabolic syndrome assume that many mechanisms are involved in its complex pathophysiology such as an increased sympathetic activity, disorders of the hypothalamo-pituitary-adrenal axis, the action of chronic subclinical infections, proinflammatory cytokines, and the effect of adipocytokines or psychoemotional stress. An increasing body of scientific research in this field confirms the role of the neurotrophins and mastocytes in the pathogenesis of inflammatory and immune diseases. Recently it has been proved that neurotrophins and mastocytes have metabotrophic effects and take part in the carbohydrate and lipid metabolism.
   In the early stage of the metabolic syndrome we established a statistically significant increase in the plasma levels of the nerve growth factor. In the generalized stage the plasma levels of the neutrophines were statistically decreased in comparison to those in the healthy controls.
   We consider that the neurotrophin deficit is likely to play a significant pathogenic rote in the development of the metabolic anthropometric and vascular manifestations of the generalized stage of MetSyn.
   We suggest a hypothesis for the etiopathogenesis of the metabolic syndrome based on the neuro-immuno-endocrine interactions.
   The specific pathogenic pathways of MetSyn development include: (1) increased tissue and plasma levels of proinflammatory cytokines Interleukin-1 (IL-1), Interleukin-6 (IL-6) and tumor necrosis factor - alpha (TNF-alpha) caused by inflammatory and/or emotional distress; (2) increased plasma levels of neurotrophin - nerve growth factor (NGF) caused by the high IL-1, IL-6 and TNF alpha levels; (3) high plasma levels of NGF which enhance activation of: the autonomous nerve system - vegetodystonia (disbalance of neurotransmitters); Neuropeptide Y (NPY) - enhanced feeding, obesity and increased leptin plasma levels; hypothalamo-pituitary-adrenal axis - increased corticotropin-releasing hormone (CRH) and cortisol (hormonal disbalance); immune cells - increased number and degranulation of mastocytes (MC) - immunological disbalance; (4) as a result of 1-3 insulin resistance is exhibited leading to diabetes mellitus.
   The hypothesis is confirmed by results obtained after 6-month nonsteroid anti-inflammatory treatment of patients with MetSyn. These results are reported in a separate publication. (c) 2005 Elsevier Ltd. All rights reserved.
C1 Varna Univ Med, Dept Endocrinol, BG-9003 Varna, Bulgaria.
   Inst Neurobiol & Mol Med, Rome, Italy.
C3 Medical University Varna
RP Varna Univ Med, Dept Endocrinol, 17 Mur St,Entr 2, BG-9003 Varna, Bulgaria.
EM library@io-bas.bg
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NR 31
TC 73
Z9 80
U1 0
U2 5
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0306-9877
EI 1532-2777
J9 MED HYPOTHESES
JI Med. Hypotheses
PY 2006
VL 66
IS 3
BP 545
EP 549
DI 10.1016/j.mehy.2005.08.055
PG 5
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 026EF
UT WOS:000236319200018
PM 16298496
DA 2025-06-11
ER

PT J
AU Çakit, O
   Gümüstepe, A
   Çakit, BD
   Vural, SP
   Özgün, T
   Genç, H
AF Cakit, Onat
   Gumustepe, Alper
   Cakit, Burcu Duyur
   Vural, Secil Pervane
   Ozgun, Tuba
   Genc, Hakan
TI Coexistence of fibromyalgia and metabolic syndrome in females: The
   effects on fatigue, clinical features, pain sensitivity, urinary
   cortisol and norepinephrine levels: A cross-sectional study
SO ARCHIVES OF RHEUMATOLOGY
LA English
DT Article
DE Fibromyalgia; metabolic syndrome; obesity; pain pressure threshold
ID INSULIN-RESISTANCE; HYPOTHALAMIC-PITUITARY; RISK-FACTORS; HEART-RATE;
   POPULATION; OBESITY; CATECHOLAMINES; ASSOCIATION; PREVALENCE; PLASMA
AB Objectives: This study aims to evaluate the coexistence of metabolic syndrome (MetS) and fibromyalgia syndrome (FMS) and determine the effects of this coexistence on neuroendocrine levels and clinical features of FMS.
   Patients and methods: One-hundred female FMS patients (mean age: 40.1 +/- 7.8 years; range, 24 to 58 years) and 38 healthy females (mean age: 40.4 +/- 5.8 years; range, 30 to 55 years) were included in this cross-sectional study. MetS was identified by using the criteria from the Adult Treatment Panel III. Widespread pain index, symptom severity score and number of tender points were determined. Visual analog scale, Fibromyalgia Impact Questionnaire, Fatigue Severity Scale, Beck Depression Inventory, and pain pressure threshold were used as the outcome measures. The severity of FMS was assessed with total myalgic score (TMS) and control point score.
   Results: Twenty-four (24%) of the 100 FMS patients and three (7.9%) of the 38 control patients fulfilled the MetS criteria (p=0.047). The coexistence of FMS and MetS was associated with higher symptom severity score (p=0.004), widespread pain index (p=0.001), number of tender points (p=0.039), and lower total myalgic score (p=0.029) values. There was a significant association between the occurrence of FMS and MetS (odds ratio=3.76; 95% confidence interval: 1.04-13.4; p=0.043).
   Conclusion: We found that patients with FMS had a nearly four times higher risk for MetS and the coexisting MetS may increase the severity of FMS. In clinical practice, when evaluating a patient with FMS, metabolic characteristics should also be evaluated.
C1 [Cakit, Onat] Univ Hlth Sci, Ankara Training & Res Hosp, Dept Family Med, Ankara, Turkey.
   [Gumustepe, Alper] Kahramankazan Goverment Hosp, Dept Phys Med & Rehabil, Ankara, Turkey.
   [Cakit, Burcu Duyur; Vural, Secil Pervane; Genc, Hakan] Univ Hlth Sci, Ankara Training & Res Hosp, Dept Phys Med & Rehabil, Ankara, Turkey.
   [Ozgun, Tuba] Univ Hlth Sci, Ankara Training & Res Hosp, Dept Biochem, Ankara, Turkey.
C3 Ankara Training & Research Hospital; University of Health Sciences
   Turkey; University of Health Sciences Turkey; Ankara Training & Research
   Hospital; University of Health Sciences Turkey; Ankara Training &
   Research Hospital
RP Vural, SP (corresponding author), Ankara Egitim Arastirma Hastanesi, Fiz Tedavi Rehabil Klin, TR-06230 Ankara, Turkey.
EM secilvural@hotmail.com
RI duyur cakit, burcu/HJA-0112-2022; Cakit, Mehmet Onat/HNQ-2984-2023;
   Genc, Hakan/CAA-4799-2022
OI Cakit, Mehmet Onat/0000-0002-6880-4633; Genc, Hakan/0000-0003-2573-4564
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NR 45
TC 11
Z9 11
U1 0
U2 6
PU TURKISH LEAGUE AGAINST RHEUMATISM
PI ANKARA
PA TALATPASA BULVARI DUMLUPINAR CAD 40 3 CEBECI DORTYOL, ANKARA, 06100,
   TURKEY
EI 2618-6500
J9 ARCH RHEUMATOL
JI Arch. Rheumatol.
PD MAR
PY 2021
VL 36
IS 1
BP 26
EP 37
DI 10.46497/ArchRheumatol.2021.7534
PG 12
WC Rheumatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Rheumatology
GA QP0KO
UT WOS:000623526400004
PM 34046566
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Li, QK
   Yin, WD
   Cai, MB
   Liu, Y
   Hou, HJ
   Shen, QY
   Zhang, C
   Xiao, JX
   Hu, XB
   Wu, QSS
   Funaki, M
   Nakaya, Y
AF Li, Qinkai
   Yin, Weidong
   Cai, Manbo
   Liu, Yi
   Hou, Hongjie
   Shen, Qingyun
   Zhang, Chi
   Xiao, Junxia
   Hu, Xiaobo
   Wu, Qishisan
   Funaki, Makoto
   Nakaya, Yutaka
TI NO-1886 suppresses diet-induced insulin resistance and cholesterol
   accumulation through STAT5-dependent upregulation of IGF1 and CYP7A1
SO JOURNAL OF ENDOCRINOLOGY
LA English
DT Article
ID GROWTH-FACTOR-I; DENSITY-LIPOPROTEIN CHOLESTEROL; ACTIVATED
   RECEPTOR-ALPHA; BILE-ACID SYNTHESIS; GENE-TRANSCRIPTION;
   7-ALPHA-HYDROXYLASE GENE; METABOLIC-SYNDROME; DIABETES-MELLITUS; NUCLEAR
   RECEPTORS; LIPASE ACTIVITY
AB Insulin resistance and dyslipidemia are both considered to be risk factors for metabolic syndrome. Low levels of IGF1 are associated with insulin resistance. Elevation of low-density lipoprotein cholesterol (LDL-C) concomitant with depression of high-density lipoprotein cholesterol (HDL-C) increase the risk of obesity and type 2 diabetes mellitus (T2DM). Liver secretes IGF1 and catabolizes cholesterol regulated by the rate-limiting enzyme of bile acid synthesis from cholesterol 7 alpha-hydroxylase (CYP7A1). NO-1886, a chemically synthesized lipoprotein lipase activator, suppresses diet-induced insulin resistance with the improvement of HDL-C. The goal of the present study is to evaluate whether NO-1886 upregulates IGF1 and CYP7A1 to benefit glucose and cholesterol metabolism. By using human hepatoma cell lines (HepG2 cells) as an in vitro model, we found that NO-1886 promoted IGF1 secretion and CYP7A1 expression through the activation of signal transducer and activator of transcription 5 (STAT5). Pretreatment of cells with AG 490, the inhibitor of STAT pathway, completely abolished NO1886-induced IGF1 secretion and CYP7A1 expression. Studies performed in Chinese Bama minipigs pointed out an augmentation of plasma IGF1 elicited by a single dose administration of NO-1886. Long-term supplementation with NO-1886 recovered hyperinsulinemia and low plasma levels of IGF1 suppressed LDL-C and facilitated reverse cholesterol transport by decreasing hepatic cholesterol accumulation through increasing CYP7A1 expression in high-fat/high-sucrose/high-cholesterol diet minipigs. These findings indicate that NO-1886 upregulates IGF1 secretion and CYP7A1 expression to improve insulin resistance and hepatic cholesterol accumulation, which may represent an alternative therapeutic avenue of NO-1886 for T2DM and metabolic syndrome. Journal of Endocrinology (2010) 204, 47-56
C1 [Li, Qinkai; Yin, Weidong; Cai, Manbo; Liu, Yi; Hou, Hongjie; Shen, Qingyun; Zhang, Chi; Xiao, Junxia; Hu, Xiaobo] Univ S China, Life Sci Res Ctr, Inst Cardiovasc Res, Key Lab Atherosclerol Hunan Prov, Hengyang 421001, Hunan, Peoples R China.
   [Li, Qinkai; Wu, Qishisan; Nakaya, Yutaka] Univ Tokushima, Grad Sch, Inst Hlth Biosci, Dept Nutr & Metab, Tokushima 7708503, Japan.
   [Li, Qinkai; Funaki, Makoto] Tokushima Univ Hosp, Clin Res Ctr Diabet, Tokushima 7708503, Japan.
C3 University of South China; Tokushima University; Tokushima University
RP Yin, WD (corresponding author), Univ S China, Life Sci Res Ctr, Inst Cardiovasc Res, Key Lab Atherosclerol Hunan Prov, Hengyang 421001, Hunan, Peoples R China.
EM wdy20042004@126.com
RI Hu, xiaobo/LVR-4333-2024
FU Project 973 of China [G2000056905]; National Natural Sciences Foundation
   of China [30370675, 30470720]
FX The research was supported in part from Project 973 of China G2000056905
   and the National Natural Sciences Foundation of China (project 30370675
   and 30470720).
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NR 52
TC 15
Z9 18
U1 0
U2 9
PU BIOSCIENTIFICA LTD
PI BRISTOL
PA EURO HOUSE, 22 APEX COURT WOODLANDS, BRADLEY STOKE, BRISTOL BS32 4JT,
   ENGLAND
SN 0022-0795
EI 1479-6805
J9 J ENDOCRINOL
JI J. Endocrinol.
PD JAN
PY 2010
VL 204
IS 1
BP 47
EP 56
DI 10.1677/JOE-09-0278
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 568MW
UT WOS:000275527500006
PM 19815588
OA Bronze
DA 2025-06-11
ER

PT J
AU Franklin, C
   Stoffels-Weindorf, M
   Hillen, U
   Dissemond, J
AF Franklin, Cindy
   Stoffels-Weindorf, Maren
   Hillen, Uwe
   Dissemond, Joachim
TI Ulcerated necrobiosis lipoidica as a rare cause for chronic leg ulcers:
   case report series of ten patients
SO INTERNATIONAL WOUND JOURNAL
LA English
DT Article
DE Chronic wound; Diabetes mellitus; Leg ulcer; Metabolic syndrome;
   Necrobiosis lipoidica
ID SQUAMOUS-CELL CARCINOMA; FUMARIC-ACID ESTERS; SIGNIFICANT IMPROVEMENT;
   INFLAMMATORY DISEASES; VENOUS INSUFFICIENCY; DIMETHYLFUMARATE;
   DIABETICORUM; MULTICENTER; THERAPY
AB Necrobiosis lipoidica is a rare granulomatous disorder of the skin. In up to 30% of the affected patients it can lead to ulcerations, which can impair the quality of life and are also very difficult to treat. Its pathogenesis is not fully understood. Only few studies focussing on necrobiosis lipoidica can be found, but none of them focus on ulcerated necrobiosis lipoidica. Therefore, we collected demographic data and comorbidities and assessed treatment options for patients with ulcerated necrobiosis lipoidica. Data of patients who were treated in the wound care centre of the University Hospital of Essen for ulcerated necrobiosis lipoidica over the past 10 years were retrospectively analysed. Hence, data of altogether ten patients (nine women and one man) with ulcerated necrobiosis lipoidica were collected. Of these, 70% of the patients had diabetes mellitus of which 30% had type I diabetes and 40% had type II diabetes; 60% of the patients suffered from arterial hypertension, obesity and hypercholesterolaemia; 40% of the patients suffered from psychiatric disorders such as depression and borderline disorder. Our clinical data demonstrate an association of ulcerated necrobiosis lipoidica and aspects of metabolic syndrome. This leads to a conclusion that ulcerating necrobiosis lipoidica can be seen as part of a generalised inflammatory reaction similar to the inflammatory reaction already known in the pathophysiology of rheumatoid diseases or psoriasis. In patients with clinical atypical painful ulcerations, necrobiosis lipoidica should be considered as a possible differential diagnosis. Therapists should be aware of associated aspects in patients with ulcerated necrobiosis lipoidica who besides diabetes often suffer from other aspects of a metabolic syndrome with increased cardiovascular risk factors. Therefore, these related comorbidities should also be diagnosed and treated.
C1 [Franklin, Cindy; Stoffels-Weindorf, Maren; Hillen, Uwe; Dissemond, Joachim] Univ Duisburg Essen, Dept Dermatol Venereol & Allergol, Univ Hosp Essen, D-45177 Essen, Germany.
C3 University of Duisburg Essen
RP Dissemond, J (corresponding author), Univ Essen Gesamthsch, Dept Dermatol Venereol & Allergol, Hufelandstr 55, D-45177 Essen, Germany.
EM joachim.dissemond@uk-essen.de
RI Franklin, Cindy/AAU-4915-2021; Dissemond, Joachim/AFG-0691-2022
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NR 43
TC 18
Z9 19
U1 0
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-4801
EI 1742-481X
J9 INT WOUND J
JI Int. Wound J.
PD OCT
PY 2015
VL 12
IS 5
BP 548
EP 554
DI 10.1111/iwj.12159
PG 7
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA CU8RL
UT WOS:000363810700010
PM 24119190
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Carroll, S
   Borkoles, E
   Polman, R
AF Carroll, Sean
   Borkoles, Erika
   Polman, Remco
TI Short-term effects of a non-dieting lifestyle intervention program on
   weight management, fitness, metabolic risk, and psychological wellbeing
   in obese premenopausal females with the metabolic syndrome
SO APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
LA English
DT Article
DE metabolic syndrome; lifestyle intervention; "Health at Every Size";
   psychological well-being; obesity; cardiorespiratory fitness;
   non-dieting approach; self-determination
ID QUALITY-OF-LIFE; 3RD NATIONAL-HEALTH; PHYSICAL-ACTIVITY;
   INSULIN-RESISTANCE; DEPRESSION SYMPTOMS; DIABETES-MELLITUS;
   BLOOD-PRESSURE; EXERCISE; PREVENTION; WOMEN
AB Lifestyle modification has been widely acknowledged as the primary treatment for the metabolic syndrome (MetS). We examined the short-term effects of a non-dieting lifestyle intervention program, within the theoretical psychological framework of self-determination theory (SDT), on metabolic fitness and psychological well-being among premenopausal, clinically obese women. A secondary analysis of a randomized, controlled, 3 month, intensive, community-based lifestyle intervention study was performed on 31 pre-menopausal obese women with the MetS (56.4% of original study sample). These participants had been randomly allocated to a non-dieting lifestyle intervention group (n = 17) or waiting list control (n = 14). Among participants who completed repeat anthropometric and cardiorespiratory fitness measurements after 3 months intervention, the lifestyle intervention group showed a significant improvement in VO2 (mL.kg(-1).min(-1)) compared with control (test for interaction, p = 0.003). No significant difference was found for body mass. Metabolic improvements were evident for diastolic blood pressure and high-density lipoprotein cholesterol in both groups. The lifestyle intervention group also showed significantly improved general psychological well-being compared with the control group (test for interaction, p = 0.0005). All of the psychological well-being subscales showed significant favourable changes in the intervention group as compared with controls. This short-term, non-dieting lifestyle intervention, consistent with the "Health at Every Size" (HAES) obesity treatment paradigm, significantly improved cardiorespiratory fitness and psychological well-being. Metabolic risk tended to improve after 3 months intervention with no significant difference in the resolution of the MetS between intervention and control participants.
C1 Univ Hull, Dept Sport Hlth & Exercise Sci, Kingston Upon Hull HU6 7RX, N Humberside, England.
   Leeds Metropolitan Univ, Carnegie Fac Sport & Educ, Leeds LS1 3HE, W Yorkshire, England.
C3 University of Hull; Leeds Beckett University
RP Carroll, S (corresponding author), Univ Hull, Dept Sport Hlth & Exercise Sci, Cottingham Rd, Kingston Upon Hull HU6 7RX, N Humberside, England.
EM s.carroll@hull.ac.uk
RI Borkoles, Erika/M-8802-2019; Polman, Remco/D-1877-2013; Borkoles,
   Erika/N-1950-2013
OI Polman, Remco/0000-0003-2951-0904; Borkoles, Erika/0000-0002-7807-8890
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NR 92
TC 46
Z9 61
U1 1
U2 35
PU CANADIAN SCIENCE PUBLISHING
PI OTTAWA
PA 65 AURIGA DR, SUITE 203, OTTAWA, ON K2E 7W6, CANADA
SN 1715-5312
EI 1715-5320
J9 APPL PHYSIOL NUTR ME
JI Appl. Physiol. Nutr. Metab.
PD FEB
PY 2007
VL 32
IS 1
BP 125
EP 142
DI 10.1139/H06-093
PG 18
WC Nutrition & Dietetics; Physiology; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nutrition & Dietetics; Physiology; Sport Sciences
GA 144ZY
UT WOS:000244836300011
PM 17332789
DA 2025-06-11
ER

PT J
AU Gottlieb, AB
   Armstrong, AW
AF Gottlieb, Alice B.
   Armstrong, April W.
TI Psoriasis Outcome Measures: A Report from the GRAPPA 2012 Annual Meeting
SO JOURNAL OF RHEUMATOLOGY
LA English
DT Article
DE PSORIATIC DISEASE; PSORIASIS; OMERACT; NATIONAL PSORIASIS FOUNDATION;
   COMORBIDITIES
ID QUALITY-OF-LIFE; SELF-ADMINISTERED PSORIASIS; SICKNESS IMPACT PROFILE;
   SHORT GENERIC VERSION; SEVERITY INDEX PASI; GLOBAL ASSESSMENT;
   INTRARATER RELIABILITY; EXAMINING INTERRATER; DISEASE SEVERITY; NAIL
   PSORIASIS
AB Psoriasis is a multisystem disease. The cutaneous and musculoskeletal manifestations (psoriatic arthritis) are well recognized. However, the other manifestations of psoriatic disease including metabolic syndrome, atherosclerotic cardiovascular disease, depression, poor self-esteem, and self-destructive habits including obesity, smoking and excess alcohol consumption are underappreciated. At the 2012 annual meeting of the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA), members addressed the need to develop uniform, validated, standardized outcome measures for psoriatic disease, measures that are useful to all stakeholders including patients, physicians, regulators, and payers.
C1 [Gottlieb, Alice B.] Tufts Med Ctr, Dept Dermatol, Boston, MA 02111 USA.
   [Armstrong, April W.] Univ Calif Davis, Dept Dermatol, Sacramento, CA 95817 USA.
C3 Tufts Medical Center; University of California System; University of
   California Davis
RP Gottlieb, AB (corresponding author), Tufts Med Ctr, 800 Washington St,Box 114, Boston, MA 02111 USA.
EM agottlieb@tuftsmedicalcenter.org
FU Advancing Innovation in Dermatology Foundation
FX Supported in part by a grant from the Advancing Innovation in
   Dermatology Foundation.
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NR 64
TC 24
Z9 24
U1 0
U2 6
PU J RHEUMATOL PUBL CO
PI TORONTO
PA 365 BLOOR ST E, STE 901, TORONTO, ONTARIO M4W 3L4, CANADA
SN 0315-162X
EI 1499-2752
J9 J RHEUMATOL
JI J. Rheumatol.
PD AUG
PY 2013
VL 40
IS 8
BP 1428
EP 1433
DI 10.3899/jrheum.130456
PG 6
WC Rheumatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Rheumatology
GA 202CY
UT WOS:000323192300034
PM 23908539
OA Bronze
DA 2025-06-11
ER

PT J
AU Bambhroliya, Z
   Sandrugu, J
   Lowe, M
   Okunlola, O
   Raza, S
   Osasan, S
   Sethia, S
   Batool, T
   Hamid, P
AF Bambhroliya, Zarna
   Sandrugu, Joel
   Lowe, Michael
   Okunlola, Oluwasemilore
   Raza, Shafaat
   Osasan, Stephen
   Sethia, Sudiksha
   Batool, Tayyaba
   Hamid, Pousette
TI Diabetes, Polycystic Ovarian Syndrome, Obstructive Sleep Apnea, and
   Obesity: A Systematic Review and Important Emerging Themes
SO CUREUS JOURNAL OF MEDICAL SCIENCE
LA English
DT Review
DE visceral adiposity; metabolic syndrome; diabetes type 2; metabolic
   dysfunction; obesity; hyperandrogenism; polycystic ovary syndrome;
   obstructive sleep apnea; insulin resistance
ID QUALITY-OF-LIFE; METABOLIC SYNDROME; DIAGNOSTIC-CRITERIA; NECK
   CIRCUMFERENCE; BLOOD-PRESSURE; WOMEN; MANAGEMENT; INSULIN; METAANALYSIS;
   ALDOSTERONE
AB Type 2 diabetes mellitus (DM), polycystic ovarian syndrome (PCOS), obstructive sleep apnea (OSA), and obesity represent four large and growing patient populations. A great deal of scientific and clinical knowledge has been developed for them individually, and significant advancements made. Taken as a group, however, the interrelationships are not as well understood. The purpose of this systematic review is to identify the body of existing research that ties them together and then to identify and discuss the prevailing themes, particularly for cause-and-effect mechanisms. PubMed, Google Scholar, and ScienceDirect were used to identify systematic reviews and meta-analysis articles to establish the broadest reach. Initially, 434 articles were carefully screened, out of which 22 most relevant studies were reviewed. Five important themes were distilled from these papers based on continued and consistent emphasis in the literature. These themes include topics such as the importance of considering visceral obesity rather than Body Mass Index (BMI), the most effective treatment approaches, including mounting support for melatonin and circadian rhythm management, the results of OSA in its feed-forward contribution to hormone imbalance, the role of non-obesity-related risk factors to PCOS and OSA such as age and genetic predisposition, and growing evidence to suggest the importance of mental health as a comorbidity in addition to the more traditional ones such as cardiovascular pathology. A new framework for investigating the interaction across these four disorders is offered that includes a revised perspective on the specific role of PCOS, perhaps being further upstream relative to the others. There currently exists a lack of well-designed randomized controlled trials in this particular area of medicine, an endeavor we believe could result in significant value, particularly as it relates to treatment approaches.
C1 [Bambhroliya, Zarna; Sandrugu, Joel; Lowe, Michael; Okunlola, Oluwasemilore; Raza, Shafaat; Osasan, Stephen; Sethia, Sudiksha; Batool, Tayyaba] Calif Inst Behav Neurosci & Psychol, Res, Fairfield, CT USA.
   [Hamid, Pousette] Calif Inst Behav Neurosci & Psychol, Neurol, Fairfield, CT USA.
RP Bambhroliya, Z (corresponding author), Calif Inst Behav Neurosci & Psychol, Res, Fairfield, CT USA.
EM zarna5060@gmail.com
RI Raza, Shafaat/ABQ-4353-2022
OI raza, Dr.shafaat/0000-0002-3186-4587; Okunlola,
   Oluwasemilore/0000-0003-2031-5766
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NR 66
TC 12
Z9 13
U1 0
U2 3
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
EI 2168-8184
J9 CUREUS J MED SCIENCE
JI Cureus J Med Sci
PD JUN 25
PY 2022
VL 14
IS 6
AR e26325
DI 10.7759/cureus.26325
PG 11
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA 3N7JM
UT WOS:000836321900021
PM 35911341
DA 2025-06-11
ER

PT J
AU Heo, IR
   Kim, TH
   Jeong, JH
   Heo, M
   Ju, SM
   Yoo, JW
   Lee, SJ
   Cho, YJ
   Jeong, YY
   Lee, JD
   Kim, HC
AF Heo, I. Re
   Kim, Tae Hoon
   Jeong, Jong Hwan
   Heo, Manbong
   Ju, Sun Mi
   Yoo, Jung-Wan
   Lee, Seung Jun
   Cho, Yu Ji
   Jeong, Yi Yeong
   Lee, Jong Deog
   Kim, Ho Cheol
TI Impact of Alcohol Consumption on Quality of Life, Depressive Mood and
   Metabolic Syndrome in Obstructive Lung Disease Patients: Analysis of
   Data from Korean National Health and Nutrition Examination Survey from
   2014 and 2016
SO TUBERCULOSIS AND RESPIRATORY DISEASES
LA English
DT Article
DE Alcohol; Quality of Life; Obstructive Lung Disease; Depression
ID PULMONARY-DISEASE; COPD; EXACERBATIONS; PREVALENCE; HOSPITALIZATIONS;
   MANAGEMENT; DIAGNOSIS
AB Background: The objective of this study was to investigate whether alcohol consump- tion might affect the quality of life (QOL), depressive mood, and metabolic syndrome in patients with obstructive lung disease (OLD).Methods: Data were obtained from the Korean National Health and Nutrition Examina-tion Survey from 2014 and 2016. OLD was defined as spirometry of forced expiratory volume in 1 second/forced vital capacity <0.7 in those aged more than 40 years. QOL was evaluated using the European Quality of Life Questionnaire-5D (EQ-5D) index. Patient Health Questionnaire-9 (PHQ-9) was used to assess the severity of depressive mood. Alcohol consumption was based on a history of alcohol ingestion during the pre-vious month.Results: A total of 984 participants with OLD (695 males, 289 females, age 65.8 +/- 9.7 years) were enrolled. The EQ-5D index was significantly higher in alcohol drinkers (n=525) than in non-alcohol drinkers (n=459) (0.94 +/- 0.11 vs. 0.91 +/- 0.13, p=0.002). PHQ-9 scores were considerably lower in alcohol drinkers than in non-alcohol drinkers (2.15 +/- 3. 57 vs. 2.78 +/- 4.13, p=0.013). However, multiple logistic regression analysis showed that alcohol consumption was not associated with EQ-5D index or PHQ-9 score. Body mass index >= 25 kg/m2, triglyceride >= 150 mg/dL, high-density lipoprotein <40 mg/dL in men and <50 mg/dL in women, and blood pressure >= 130/85 mm Hg were significantly more common in alcohol drinkers than in non-alcohol drinkers (all p<0.05).Conclusion: Alcohol consumption did not change the QOL or depressive mood of OLD patients. However, metabolic syndrome-related factors were more common in alcohol drinkers than in non-alcohol drinkers.
C1 [Heo, I. Re; Kim, Tae Hoon; Kim, Ho Cheol] Gyeongsang Natl Univ, Coll Med, Dept Internal Med, Changwon Hosp, Chang Won, South Korea.
   [Jeong, Jong Hwan; Heo, Manbong; Ju, Sun Mi; Yoo, Jung-Wan; Lee, Seung Jun; Cho, Yu Ji; Jeong, Yi Yeong; Lee, Jong Deog] Gyeongsang Natl Univ, Gyeongsang Natl Univ Hosp, Dept Internal Med, Coll Med, Jinju, South Korea.
   [Kim, Ho Cheol] Gyeongsang Natl Univ, Coll Med, Dept Internal Med, Changwon Hosp, 11 Samjeongja Ro, Chang Won 51472, South Korea.
C3 Gyeongsang National University; Gyeongsang National University;
   Gyeongsang National University Hospital; Gyeongsang National University
RP Kim, HC (corresponding author), Gyeongsang Natl Univ, Coll Med, Dept Internal Med, Changwon Hosp, 11 Samjeongja Ro, Chang Won 51472, South Korea.
EM hochkim@gnu.ac.kr
RI Kim, Cheol-Hee/F-6278-2013
OI Heo, I Re/0000-0002-5832-5233
CR Agustí AGN, 2003, EUR RESPIR J, V21, P347, DOI 10.1183/09031936.03.00405703
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NR 29
TC 4
Z9 4
U1 0
U2 2
PU TAEHAN KYORHAEK HYOPHOE-KOREAN ACAD TUBERCULOSIS & RESPIRATORY DISEASES
PI SEOUL
PA 101-605 SEOCHO ART XI 1583-10 SEOCHO 3-DONG, SEOCHO-GU, SEOUL, 137-875,
   SOUTH KOREA
SN 1738-3536
EI 2005-6184
J9 TUBERC RESPIR DIS
JI Tuberc. Respir. Dis.
PD APR
PY 2023
VL 86
IS 2
BP 111
EP 119
DI 10.4046/trd.2022.0107
PG 9
WC Respiratory System
WE Emerging Sources Citation Index (ESCI)
SC Respiratory System
GA D6BR1
UT WOS:000969569600005
PM 37005091
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Ek, C
   Hebert, JR
   Friedman, DB
   Porter, DE
AF Ek, Christina
   Hebert, James R.
   Friedman, Daniela B.
   Porter, Dwayne E.
TI Climate Change, Racism, and Food Insecurity: Cyclical Impacts of
   Stressors Exacerbate Health Disparities
SO JOURNAL OF RACIAL AND ETHNIC HEALTH DISPARITIES
LA English
DT Review; Early Access
DE Climate change; Racism; Dietary Inflammatory Index; Allostatic load;
   Chronic disease; Health disparities
ID METABOLIC SYNDROME; JOHN HENRYISM; NUTRITION; MALNUTRITION; ETHNICITY;
   DYNAMICS; COVID-19; OBESITY; RISK
AB IntroductionDisadvantaged populations have higher rates of chronic disease, including heart disease, cancer, and diabetes. Race, ethnicity, lower socioeconomic status, and poverty all contribute to these disproportionate rates. Other factors, including systemic racism, climate change, poor diet, lack of food access, and epigenetic influences, that are distributed and experienced differently across vulnerable populations also play a significant role in the development of chronic diseases. This comprehensive review of contributors to chronic diseases emphasizes a unique focus on these identified emerging factors.MethodsAn ad hoc literature review using OVID Medline and Web of Science was conducted.ResultsFindings from prior studies indicate that multiple stressors, both in isolation and in combination, and their negative impacts on both physical and mental health of minorities are exacerbated by climate change.DiscussionVarious stressors dramatically increase chronic disease risk in minority groups. Recommendations for future research to elucidate the impacts of climatic, racial, and dietary adversity with minority populations are presented. Further study in this area is critical for achieving the UN Sustainable Development Goals and improving public health outcomes.
C1 [Ek, Christina; Porter, Dwayne E.] Univ South Carolina, Arnold Sch Publ Hlth, Dept Environm Hlth Sci, Columbia, SC 29208 USA.
   [Hebert, James R.] Univ South Carolina, Dept Epidemiol & Biostat, Columbia, SC USA.
   [Hebert, James R.] Univ South Carolina, Canc Prevent & Control Program, Columbia, SC USA.
   [Friedman, Daniela B.] Univ South Carolina, Arnold Sch Publ Hlth, Dept Hlth Promot Educ & Behav, Columbia, SC USA.
C3 University of South Carolina System; University of South Carolina
   Columbia; University of South Carolina System; University of South
   Carolina Columbia; University of South Carolina System; University of
   South Carolina Columbia; University of South Carolina System; University
   of South Carolina Columbia
RP Ek, C (corresponding author), Univ South Carolina, Arnold Sch Publ Hlth, Dept Environm Hlth Sci, Columbia, SC 29208 USA.
EM ekl@email.sc.edu
RI Hebert, James/IUO-5628-2023; Friedman, Daniela/IAR-1058-2023
FU Carolinas Consortium
FX Open access funding provided by the Carolinas Consortium.
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NR 82
TC 0
Z9 0
U1 3
U2 4
PU SPRINGER INT PUBL AG
PI CHAM
PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND
SN 2197-3792
EI 2196-8837
J9 J RACIAL ETHN HEALTH
JI J. Racial Ethn. Health Disparities
PD 2024 OCT 16
PY 2024
DI 10.1007/s40615-024-02202-x
EA OCT 2024
PG 12
WC Public, Environmental & Occupational Health
WE Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA I9M0X
UT WOS:001333410100001
PM 39412743
OA hybrid
DA 2025-06-11
ER

PT J
AU Wärdig, R
   Bachrach-Lindström, M
   Hultsjö, S
   Lindström, T
   Foldemo, A
AF Wardig, Rikard
   Bachrach-Lindstrom, Margareta
   Hultsjo, Sally
   Lindstrom, Torbjorn
   Foldemo, Anniqa
TI Persons with psychosis perceptions of participating in a lifestyle
   intervention
SO JOURNAL OF CLINICAL NURSING
LA English
DT Article
DE lifestyle intervention; metabolic syndrome; nursing; perceptions;
   psychosis; qualitative method
ID MENTAL-HEALTH-SERVICES; SELF-CARE; PHYSICAL-ACTIVITY; SCHIZOPHRENIA;
   INDIVIDUALS; ILLNESS; PHENOMENOGRAPHY
AB Aims and objectivesTo describe how persons with psychosis perceive participation in a lifestyle intervention, and use these perceptions to present factors to for consideration in future interventions.
   BackgroundMetabolic syndrome is common in persons with psychosis. A healthy lifestyle is the primary option for preventing and treating metabolic syndrome, which is why the importance of lifestyle interventions has come into focus among health care professionals. Identifying perceptions of participation in a lifestyle intervention can increase the understanding of how to design future interventions.
   DesignA qualitative, phenomenographic approach was selected, using semi-structured interviews.
   MethodsThe sample consisted of 40 participants with a psychotic disorder, who had undergone a lifestyle intervention focusing on theoretical education in healthy eating and physical activities. The interviews were conducted in 2011 and 2012, six to seven months after the intervention had been completed.
   ResultsThe findings comprise three categories that emphasise the need for a moderate intervention level that facilitates participation and thereby social interactions among group members. The experience of success in the intervention supported the perception of oneself as a capable individual. However, it could also be the opposite, another experience of failure.
   ConclusionContent in moderation can facilitate participation, and participants can thereby achieve health benefits and find social contacts. In addition to physical activity and lifestyle habits, interventions should have a social focus and be continuous. Professional support is a prerequisite and should facilitate the participants' ability to mirror themselves against healthy people in society by introducing activities that ordinary people do.
   Relevance for clinical practiceIdentifying perceptions of participation in a lifestyle intervention can increase the understanding of how to design and manage future interventions. This is also an aspect that is important to consider in everyday clinical practice.
C1 [Wardig, Rikard; Bachrach-Lindstrom, Margareta; Lindstrom, Torbjorn; Foldemo, Anniqa] Linkoping Univ, Dept Med & Hlth Sci, S-58183 Linkoping, Sweden.
   [Hultsjo, Sally] Ryhov Cty Hosp, Psychiat Clin, Jonkoping, Sweden.
C3 Linkoping University
RP Wärdig, R (corresponding author), Linkoping Univ, Dept Med & Hlth Sci, S-58183 Linkoping, Sweden.
EM rikard.wardig@liu.se
FU County Council of Ostergotland; Linkoping University; Psychiatric
   Clinic, county Hospital, Ryhov, Jonkoping, Sweden
FX This study was financially supported by the County Council of
   Ostergotland and Linkoping University and the Psychiatric Clinic, county
   Hospital, Ryhov, Jonkoping, Sweden.
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   Wärdig RE, 2013, ISSUES MENT HEALTH N, V34, P602, DOI 10.3109/01612840.2013.790525
NR 34
TC 12
Z9 13
U1 0
U2 10
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0962-1067
EI 1365-2702
J9 J CLIN NURS
JI J. Clin. Nurs.
PD JUL
PY 2015
VL 24
IS 13-14
BP 1815
EP 1824
DI 10.1111/jocn.12782
PG 10
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA CL3TG
UT WOS:000356872900007
PM 25664402
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Park, H
   Choi, S
   Kim, KH
   Kang, E
   Ko, A
   Park, SM
AF Park, Hyeah
   Choi, Seulggie
   Kim, Kyae Hyung
   Kang, EunKyo
   Ko, Ahryoung
   Park, Sang Min
TI Association between Social Trust and Metabolic Syndrome in a Previously
   Healthy Population-A Longitudinal Cohort Study in South Korea
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Article
DE social trust; metabolic syndrome
ID DEPRESSION; OVERWEIGHT; MORTALITY; COHESION; OBESITY; DISEASE; IMPACT;
   WOMEN; RISK; MEN
AB Background:Social trust, assessed by the trustworthiness of one another in a community, is known to have beneficial effects on health outcomes. However, the impact of social trust on metabolic syndrome (MetS) is unclear.Methods:The study subjects were extracted from the Korean National Health Insurance Service, and social trust was obtained from the Korean Community Health Survey (KCHS). Previously healthy participants were followed up from 1 January 2010 to 31 December 2011, and again from 1 January 2012 to 31 December 2013 for waist circumference, blood pressure, fasting blood glucose, triglycerides and high-density lipoprotein cholesterol (HDL-C). Multivariate logistic regression was used to calculate the adjusted odds ratios (aORs) with 95% confidence intervals (CIs) for newly developed MetS according to social trust quintiles. Stratified analyses were performed to determine the relationship between lifestyle behaviors and social trust.Results:Compared to the participants within the first quintile of social trust, those in the remaining quintiles had lower risks of developing MetS. The aOR with the 95% CI was 0.88 (0.79-0.98) in the 5th quintile group of social trust. Among the diagnostic criteria for MetS, waist circumference and HDL-C were statistically significant with aORs of 0.91 (0.84-0.99) and 0.88 (0.80-0.95) in the 5th quintile group. The stratified analyses showed protective effects of positive lifestyle behaviors. The aORs with 95% CIs were 0.85 (0.74-0.99) in never smokers, 0.82 (0.70-0.95) in non-drinkers and 0.87 (0.76-1.00) in the physically active in the highest level of social trust.Conclusions: Higher social trust was associated with a lower incidence of MetS. Therefore, building community with psychosocial support may be helpful in improving public health.
C1 [Park, Hyeah; Kim, Kyae Hyung; Kang, EunKyo; Park, Sang Min] Seoul Natl Univ Hosp, Dept Family Med, Seoul 03080, South Korea.
   [Choi, Seulggie; Park, Sang Min] Seoul Natl Univ, Dept Biomed Sci, Grad Sch, Seoul 03080, South Korea.
   [Kim, Kyae Hyung; Kang, EunKyo; Ko, Ahryoung] Seoul Natl Univ Hosp, Inst Publ Hlth & Med Serv, Seoul 03080, South Korea.
C3 Seoul National University (SNU); Seoul National University Hospital;
   Seoul National University (SNU); Seoul National University (SNU); Seoul
   National University Hospital
RP Park, SM (corresponding author), Seoul Natl Univ Hosp, Dept Family Med, Seoul 03080, South Korea.; Park, SM (corresponding author), Seoul Natl Univ, Dept Biomed Sci, Grad Sch, Seoul 03080, South Korea.
EM hyeahp@snu.ac.kr; seulggie@gmail.com; truwhat@gmail.com;
   ekherb@naver.com; ahryoungko@gmail.com; smpark.snuh@gmail.com
RI Kim, Sang/J-5399-2012; Park, Sang/V-9194-2019
OI Kim, Kyae Hyung/0000-0001-9954-6422; Kang, EunKyo/0000-0001-5844-5625;
   Park, Sang Min/0000-0002-7498-4829; Ko, Ahryoung/0000-0001-8381-5595
FU Korean Centers for Disease Control and Prevention [2018P330400];
   BK21-Plus Education Program from the National Research Foundation of
   Korea
FX This research was supported by the Korean Centers for Disease Control
   and Prevention (grant number: 2018P330400). S. Choi received grants from
   the BK21-Plus Education Program from the National Research Foundation of
   Korea.
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NR 31
TC 5
Z9 5
U1 0
U2 4
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD AUG
PY 2020
VL 17
IS 16
AR 5629
DI 10.3390/ijerph17165629
PG 12
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA NI5HA
UT WOS:000565381400001
PM 32764218
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Rubenfire, M
   Mollo, L
   Krishnan, S
   Finkel, S
   Weintraub, M
   Gracik, T
   Kohn, D
   Oral, EA
AF Rubenfire, Melvyn
   Mollo, Lynette
   Krishnan, Sangeetha
   Finkel, Sandra
   Weintraub, Martha
   Gracik, Theresa
   Kohn, Daniel
   Oral, Elif A.
TI The Metabolic Fitness Program LIFESTYLE MODIFICATION FOR THE METABOLIC
   SYNDROME USING THE RESOURCES OF CARDIAC REHABILITATION
SO JOURNAL OF CARDIOPULMONARY REHABILITATION AND PREVENTION
LA English
DT Article
DE cardiac rehabilitation; lifestyle; modification; medical fitness
   program; metabolic syndrome
ID 3RD NATIONAL-HEALTH; WEIGHT-LOSS; SCIENTIFIC STATEMENT; CARDIOVASCULAR
   RISK; MEDITERRANEAN DIET; EXERCISE; INTERVENTION; PREVALENCE; NUTRITION;
   PREVENTION
AB PURPOSE: To describe and assess the effectiveness of a lifestyle intervention program (Met Fit) designed to treat the metabolic syndrome (MetSyn) in a cardiac rehabilitation setting.
   METHODS: Met Fit is a physician referred and patient pay ($350) program consisting of 12 weekly sessions of 45 minutes of exercise and 45 minutes of education with target exercise recommendations of 150 to 200 minutes weekly and 5% loss in body weight using a Mediterranean-style diet. Primary outcomes are compliance with program recommendations and secondary outcomes effecting MetSyn components.
   RESULTS: Patients (N = 126) were enrolled between June 2005 and July 2009 averaging 9 per class. Mean (SD) age was 51(12) years, body mass index 38(6.9) kg/m(2), high density lipoprotein-cholesterol for men 37(9.4) mg/dL and women 46(10) mg/dL, glucose 121(39) mg/dL, and homeostatic model assessment of insulin resistance 7.2(6.1). For the 93 (73.8%) patients for whom there was complete data, mean weight loss was 6.2(6.9) kg, 63.4% lost at least 4 kg, and 19.4% lost more than 5% of weight. Significant reductions were observed in the waist circumference and body fat, and systolic and diastolic blood pressure. Triglycerides decreased significantly in both diabetics and nondiabetics but glucose decreased significantly only in diabetics. At baseline, 51% had evidence of depression, which decreased to 24.7% at 12 weeks. At program completion, 18 patients (19.4%) no longer had the MetSyn and 39 (41.9%) lost at least 1 criterion (P < .0001).
   CONCLUSIONS: A 12-week patient-pay lifestyle interventional program conducted in a cardiac rehabilitation setting can result in a highly significant benefit to patients with the MetSyn.
C1 [Rubenfire, Melvyn; Mollo, Lynette; Krishnan, Sangeetha; Finkel, Sandra; Weintraub, Martha; Gracik, Theresa; Kohn, Daniel; Oral, Elif A.] Univ Michigan, Sch Med, Div Cardiovasc Med, Ann Arbor, MI USA.
C3 University of Michigan System; University of Michigan
RP Rubenfire, M (corresponding author), 24 Frank Lloyd Wright Dr,Lobby A,Ste 3700, Ann Arbor, MI 48106 USA.
EM mrubenfi@umich.edu
OI Oral, Elif/0000-0002-9171-1144
FU Cardiovascular Medicine Preventive Cardiology Research Fund
FX Funding: Cardiovascular Medicine Preventive Cardiology Research Fund.
   The authors declare no conflict of interest.
CR [Anonymous], JAMA
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NR 37
TC 22
Z9 23
U1 2
U2 17
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1932-7501
EI 1932-751X
J9 J CARDIOPULM REHABIL
JI J. Cardiopulm. Rehabil. Prev.
PD SEP-OCT
PY 2011
VL 31
IS 5
BP 282
EP 289
DI 10.1097/HCR.0b013e318220a7eb
PG 8
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 818OX
UT WOS:000294764000003
PM 21734589
OA Bronze
DA 2025-06-11
ER

PT J
AU Dushkin, M
   Khrapova, M
   Kovshik, G
   Chasovskikh, M
   Menshchikova, E
   Trufakin, V
   Shurlygina, A
   Vereschagin, E
AF Dushkin, Michael
   Khrapova, Marina
   Kovshik, Gennadiy
   Chasovskikh, Marina
   Menshchikova, Elena
   Trufakin, Valeriy
   Shurlygina, Anna
   Vereschagin, Evgeniy
TI Effects of rhaponticum carthamoides versus glycyrrhiza glabra and punica
   granatum extracts on metabolic syndrome signs in rats
SO BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Article
DE Rhaponticum carthamoides; Metabolic syndrome; Corticosterone;
   Inflammatory cytokines
ID HIGH-FAT DIET; LEUZEA-CARTHAMOIDES; STATIN COMBINATION; CITRUS-SINENSIS;
   MICE; INSULIN; 20-HYDROXYECDYSONE; POMEGRANATE; LEVEL; FRUIT
AB Background: Rhaponticum cathamoides (RC) is an endemic wild Siberian herb with marked medicinal properties that are still poorly understood. The aim of this study is to investigate the therapeutic potential of RC extract (ERC) compared to the effects of Glycyrrhiza glabra (EGG) and Punica granatum extracts (EPG) in a rat model with high-fat diet-(HFD)-induced signs of metabolic syndrome; therefore, this study addresses a significant global public health problem.
   Methods: Six-month-old male Wistar Albino Glaxo rats were subjected to eight weeks of a standard diet (SD), HFD, or HFD in which ERC, EGG, or EPG powders were incorporated at 300 mg/kg/day. The serum lipid profile, corticosterone and cytokine concentrations, glucose tolerance, systolic blood pressure, triacylglycerol accumulation, and PPAR alpha DNA-binding activities in the liver samples were determined.
   Results: In contrast to EGG and EPG, an ERC supplement significantly reduced the weight of epididymal tissue (19.0%, p < 0.01) and basal serum glucose level (19.4%, p < 0.05). ERC improved glucose intolerance as well as dyslipidemia more efficiently than EGG and EPG. EGG but not ERC or EPG supplementation decreased systolic blood pressure by 12.0% (p < 0.05). All of the tested extracts reduced serum IL6 and corticosterone levels induced by HFD. However, the lowering effects of ERC consumption on the serum TNF-alpha level and its restoring effect on the adrenal corticosterone level significantly exceeded the improvements induced by EGG and EPG. ERC intake also reduced triacylglycerol accumulation and increased the PPAR alpha DNA-binding activity in the liver more significantly than EGG and EPG.
   Conclusions: ERC powder supplementation improved glucose and lipid metabolism more significantly than EGG and EPG in rats fed on HFD, supporting the strategy of R. carthamoides use for safe relief of metabolic syndrome and its related disturbances such as inflammation, stress, and hepatic steatosis.
C1 [Dushkin, Michael; Khrapova, Marina; Chasovskikh, Marina; Vereschagin, Evgeniy] Russian Acad Med Sci, Inst Internal Med, Siberian Branch, Lab Mol & Cellular Mech Therapeut Dis, Novosibirsk, Russia.
   [Dushkin, Michael; Kovshik, Gennadiy; Trufakin, Valeriy; Shurlygina, Anna] Russian Acad Med Sci, Siberian Branch, Inst Physiol & Fundamental Med, Novosibirsk, Russia.
   [Menshchikova, Elena] Russian Acad Med Sci, Siberian Branch, Ctr Clin & Expt Med, Novosibirsk, Russia.
C3 Russian Academy of Medical Sciences; Russian Academy of Sciences;
   Siberian Branch of the Russian Academy of Sciences; Russian Academy of
   Sciences; Siberian Branch of the Russian Academy of Sciences; Russian
   Academy of Medical Sciences; Research Institute for Neurosciences &
   Medicine; Russian Academy of Medical Sciences; Russian Academy of
   Sciences; Siberian Branch of the Russian Academy of Sciences
RP Dushkin, M (corresponding author), Russian Acad Med Sci, Inst Internal Med, Siberian Branch, Lab Mol & Cellular Mech Therapeut Dis, Novosibirsk, Russia.
EM midushkin@soramn.ru
RI Khrapova, Marina/U-5456-2019; Menshchikova, Elena/N-2062-2015
OI Menshchikova, Elena/0000-0003-2367-0114; Khrapova,
   Marina/0000-0003-3397-8067; Trufakin, Valeriy/0000-0002-8059-1108
FU Russian Foundation for Basic Research [11-04-00555a]
FX This study was supported by the Russian Foundation for Basic Research
   (11-04-00555a). The authors wish to thank Prof. Vera Selyatitskaya for
   corticosterone measurement assistance.
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NR 41
TC 17
Z9 18
U1 0
U2 21
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1472-6882
J9 BMC COMPLEM ALTERN M
JI BMC Complement. Altern. Med.
PD JAN 20
PY 2014
VL 14
AR 33
DI 10.1186/1472-6882-14-33
PG 9
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA AA5FY
UT WOS:000331122700001
PM 24444255
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU McInerney, M
   Winecoff, R
   Ayyagari, P
   Simon, K
   Bundorf, MK
AF McInerney, Melissa
   Winecoff, Ruth
   Ayyagari, Padmaja
   Simon, Kosali
   Bundorf, M. Kate
TI ACA Medicaid Expansion Associated With Increased Medicaid Participation
   and Improved Health Among Near-Elderly: Evidence From the Health and
   Retirement Study
SO INQUIRY-THE JOURNAL OF HEALTH CARE ORGANIZATION PROVISION AND FINANCING
LA English
DT Article
DE Patient Protection and Affordable Care Act; Medicaid; insurance
   coverage; health status; crowd-out; near-elderly adults;
   difference-in-differences
ID AFFORDABLE CARE ACT; 1ST 2 YEARS; INSURANCE-COVERAGE; CHILDLESS ADULTS;
   MENTAL-HEALTH; ACCESS; BEHAVIORS; DECLINE; IMPACT; DEATH
AB The Affordable Care Act (ACA) dramatically expanded health insurance, but questions remain regarding its effects on health. We focus on older adults for whom health insurance has greater potential to improve health and well-being because of their greater health care needs relative to younger adults. We further focus on low-income adults who were the target of the Medicaid expansion. We believe our study provides the first evidence of the health-related effects of ACA Medicaid expansion using the Health and Retirement Study (HRS). Using geo-coded data from 2010 to 2016, we estimate difference-in-differences models, comparing changes in outcomes before and after the Medicaid expansion in treatment and control states among a sample of over 3,000 unique adults aged 50 to 64 with income below 100% of the federal poverty level. The HRS allows us to examine morbidity outcomes not available in administrative data, providing evidence of the mechanisms underlying emerging evidence of mortality reductions due to expanded insurance coverage among the near-elderly. We find that the Medicaid expansion was associated with a 15 percentage point increase in Medicaid coverage which was largely offset by declines in other types of insurance. We find improvements in several measures of health including a 12% reduction in metabolic syndrome; a 32% reduction in complications from metabolic syndrome; an 18% reduction in the likelihood of gross motor skills difficulties; and a 34% reduction in compromised activities of daily living (ADLs). Our results thus suggest that the Medicaid expansion led to improved physical health for low-income, older adults.
C1 [McInerney, Melissa] Tufts Univ, Dept Econ, Medford, MA 02155 USA.
   [Winecoff, Ruth; Simon, Kosali] Indiana Univ, Bloomington, IN USA.
   [Ayyagari, Padmaja] Univ S Florida, Tampa, FL 33620 USA.
   [Bundorf, M. Kate] Stanford Univ, Stanford, CA 94305 USA.
C3 Tufts University; Indiana University System; Indiana University
   Bloomington; State University System of Florida; University of South
   Florida; Stanford University
RP McInerney, M (corresponding author), Tufts Univ, Braker Hall,8 Upper Campus Rd, Medford, MA 02155 USA.
EM melissa.mcinerney@tufts.edu
OI McInerney, Melissa/0000-0002-3064-8313; simon,
   kosali/0000-0002-3231-1466; Bundorf, M. Kate/0000-0002-9824-4868
FU National Institute on Aging [R03 AG059110]
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: This
   research was supported by R03 AG059110 from the National Institute on
   Aging.
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NR 50
TC 16
Z9 19
U1 1
U2 14
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0046-9580
EI 1945-7243
J9 INQUIRY-J HEALTH CAR
JI Inquiry-J. Health Care Organ. Provis. Financ.
PD JUL
PY 2020
VL 57
AR 0046958020935229
DI 10.1177/0046958020935229
PG 10
WC Health Care Sciences & Services; Health Policy & Services
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services
GA MV8WW
UT WOS:000556632000001
PM 32720837
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Korac, B
   Kalezic, A
   Pekovic-Vaughan, V
   Korac, A
   Jankovic, A
AF Korac, Bato
   Kalezic, Andjelika
   Pekovic-Vaughan, Vanja
   Korac, Aleksandra
   Jankovic, Aleksandra
TI Redox changes in obesity, metabolic syndrome, and diabetes
SO REDOX BIOLOGY
LA English
DT Article
DE Redox biomarkers; Obesity; Metabolic syndrome; Diabetes; Lipofuscin;
   NRF2; Circadian rhythms; Cancer
ID DIET-INDUCED OBESITY; FREE FATTY-ACIDS; BODY-MASS INDEX; SYSTEMIC
   OXIDATIVE STRESS; PROTEIN CARBONYL LEVELS; GLYCATION END-PRODUCT;
   BREAST-CANCER RISK; ADIPOSE-TISSUE; INSULIN-RESISTANCE; NITRIC-OXIDE
AB "Life is an instantaneous encounter of circulating matter and flowing energy" (Jean Giaja, Serbian physiologist), is one of the most elegant definitions not only of life but the relationship of redox biology and metabolism. Their evolutionary liaison has created inseparable yet dynamic homeostasis in health, which, when disrupted, leads to disease. This interconnection is even more pertinent today, in an era of increasing metabolic diseases of epidemic proportions such as obesity, metabolic syndrome, and diabetes. Despite great advances in understanding the molecular mechanisms of redox and metabolic regulation, we face significant challenges in preventing, diagnosing, and treating metabolic diseases. The etiological association and temporal overlap of these syndromes present significant challenges for the discrimination of appropriate clinical biomarkers for diagnosis, treatment, and outcome prediction. These multifactorial, multiorgan metabolic syndromes with complex etiopathogenic mechanisms are accompanied by disturbed redox equilibrium in target tissues and circulation. Free radicals and reactive species are considered both a causal factor and a consequence of disease status. Thus, determining the subtypes and levels of free radicals and reactive species, oxidatively damaged biomolecules (lipids, proteins, and nucleic acids) and antioxidant defense components as well as redox-sensitive transcription factors and fluxes of redox-dependent metabolic pathways will help define existing and establish novel redox biomarkers for stratifying metabolic diseases. This review aims to discuss diverse redox/metabolic aspects in obesity, metabolic syndrome, and diabetes, with the imperative to help establish a platform for emerging and future redoxmetabolic biomarkers research in precision medicine. Future research warrants detailed investigations into the status of redox biomarkers in healthy subjects and patients, including the use of emerging 'omic' profiling technologies (e.g., redox proteomes, lipidomes, metabolomes, and transcriptomes), taking into account the influence of lifestyle (diet, physical activity, sleep, work patterns) as well as circadian similar to 24h fluctuations in circulatory factors and metabolites.
C1 [Korac, Bato; Kalezic, Andjelika; Jankovic, Aleksandra] Univ Belgrade, Inst Biol Res Sinisa Stankovic, Dept Physiol, Natl Inst Republ Serbia, Belgrade 11000, Serbia.
   [Korac, Bato; Korac, Aleksandra] Univ Belgrade, Fac Biol, Ctr Electron Microscopy, Belgrade 11000, Serbia.
   [Pekovic-Vaughan, Vanja] Univ Liverpool, Fac Hlth & Life Sci, Inst Life Course & Med Sci, William Henry Duncan Bldg, Liverpool L7 8TX, England.
C3 University of Belgrade; University of Belgrade; University of Liverpool
RP Korac, B; Jankovic, A (corresponding author), Univ Belgrade, Natl Inst Republ Serbia, Inst Biol Res Sinisa Stankovic, Bulevar Despota Stefana 142, Belgrade 11000, Serbia.
EM koracb@ibiss.bg.ac.rs; aleksandra.jankovic@ibiss.bg.ac.rs
RI Korac, Bato/AAH-8206-2021; Kalezic, Andjelika/AAX-9082-2021; Jankovic,
   Aleksandra/ACV-5778-2022
OI Kalezic, Andjelika/0000-0002-2066-9137; Pekovic-Vaughan,
   Vanja/0000-0002-7876-652X; Jankovic, Aleksandra/0000-0002-6945-927X;
   Korac, Bato/0000-0001-5272-579X
FU Ministry of Education, Science and Technological Development of the
   Republic of Serbia [451-03-68/2020-14/200007, 451-03-68/202014/200178];
   Science Fund of the Republic of Serbia, PROMIS [6066747]; MRC New
   Investigator Research Grant; Medical Research Council (MRC) Versus
   Arthritis Centre for Integrated Research on Musculoskeletal Ageing;
   Rosetrees Trust; Wellcome Trust Institutional Strategic Fund Fellowship;
   BBSRC [BB/W010801/1] Funding Source: UKRI; MRC [MR/P003311/1,
   MR/P020941/1] Funding Source: UKRI
FX The authors are grateful for the support from the Ministry of Education,
   Science and Technological Development of the Republic of Serbia [grant
   numbers 451-03-68/2020-14/200007 and 451-03-68/202014/200178] and the
   Science Fund of the Republic of Serbia, PROMIS [grant number 6066747] as
   well as from the MRC New Investigator Research Grant, the Medical
   Research Council (MRC) Versus Arthritis Centre for Integrated Research
   on Musculoskeletal Ageing, The Rosetrees Trust and Wellcome Trust
   Institutional Strategic Fund Fellowship (VPV) .
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NR 239
TC 95
Z9 102
U1 3
U2 41
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2213-2317
J9 REDOX BIOL
JI Redox Biol.
PD JUN
PY 2021
VL 42
AR 101887
DI 10.1016/j.redox.2021.101887
EA APR 2021
PG 17
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA RY2BK
UT WOS:000647722300010
PM 33579666
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU MacAulay, RK
   Halpin, A
   Cohen, AS
   Calamia, M
   Boeve, A
   Zhang, L
   Brouillette, RM
   Foil, HC
   Bruce-Keller, A
   Keller, JN
AF MacAulay, Rebecca K.
   Halpin, Amy
   Cohen, Alex S.
   Calamia, Matthew
   Boeve, Angelica
   Zhang, Le
   Brouillette, Robert M.
   Foil, Heather C.
   Bruce-Keller, Annadora
   Keller, Jeffrey N.
TI Predictors of Heterogeneity in Cognitive Function: APOE-e4, Sex,
   Education, Depression, and Vascular Risk
SO ARCHIVES OF CLINICAL NEUROPSYCHOLOGY
LA English
DT Article
DE Cognitive decline; Modifiable risk factors; Cognitive reserve; Mild
   cognitive impairment; Alzheimer's disease
ID APOLIPOPROTEIN-E GENOTYPE; ALZHEIMER-DISEASE; METABOLIC SYNDROME;
   FOLLOW-UP; IMPAIRMENT; DEMENTIA; ASSOCIATION; SYMPTOMS; DECLINE; LIFE
AB Objective: Mild cognitive impairment and dementia are clinically heterogeneous disorders influenced by diverse risk factors. Improved characterization of the effect of multiple risk factors influence on specific cognitive functions may improve understanding of mechanisms in early cognitive change and lead to more effective interventions.
   Methods: Structural equation modeling (SEM) simultaneously examined the effects of modifiable (education, depression, and metabolic/vascular risk) and nonmodifiable risk factors (age, sex, and apolipoprotein E-epsilon 4 allele [APOE-e4] status) on specific cognitive domains in 461 cognitively normal older adults.
   Results: The hypothesized model(s) provided an adequate fit for the data. Sex differences in cognition, depression, and vascular risk were found. On average, men were higher in vascular risk with generally lower cognitive performance than women; women were more likely to have depression. APOE-e4 associated with depression but not age, sex, or metabolic/vascular risk. Depression associated with lower executive attention, memory, and language performance, whereas metabolic/vascular risk associated with lower executive attention, memory, and working memory. Older age and lower education are associated with worse performance across the cognitive domains. The combined risk factors accounted for 16%-47% of the variance in the cognitive domains.
   Conclusions: Results highlight the combined effect of risk factors on cognitive function. Future research is needed to determine whether the multifactorial risk effects on cognition vary by sex. Precision medicine approaches that integrate neuropsychological services may improve diagnostic accuracy and earlier identification of those at risk of cognitive decline.
C1 [MacAulay, Rebecca K.; Halpin, Amy; Boeve, Angelica] Univ Maine, Dept Psychol, 301 Little Hall, Orono, ME 04469 USA.
   [Cohen, Alex S.; Calamia, Matthew] Louisiana State Univ, Dept Psychol, Baton Rouge, LA 70803 USA.
   [Zhang, Le; Brouillette, Robert M.; Foil, Heather C.; Bruce-Keller, Annadora; Keller, Jeffrey N.] Inst Dementia Res & Prevent LSU, Pennington Biomed Res Ctr, Baton Rouge, LA 70808 USA.
   [Zhang, Le] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Inst Aging,Dept Geriatr, Wuhan, Peoples R China.
C3 University of Maine System; University of Maine Orono; Louisiana State
   University System; Louisiana State University; Louisiana State
   University System; Louisiana State University; Pennington Biomedical
   Research Center; Huazhong University of Science & Technology
RP MacAulay, RK (corresponding author), Univ Maine, Dept Psychol, 301 Little Hall, Orono, ME 04469 USA.
EM Rebecca.macaulay@maine.edu
RI Calamia, Matthew/AFN-8305-2022
OI MacAulay, Rebecca/0000-0002-7985-998X; Calamia,
   Matthew/0000-0002-7252-7181
FU Hibernia National Bank/Edward G. Schlieder Chair
FX This work was supported by Hibernia National Bank/Edward G. Schlieder
   Chair and private community supporters. The funders had no role in the
   study design, data collection and analysis, decision to publish, or
   preparation of the manuscript.
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NR 66
TC 15
Z9 15
U1 0
U2 17
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0887-6177
EI 1873-5843
J9 ARCH CLIN NEUROPSYCH
JI Arch. Clin. Neuropsychol.
PD SEP
PY 2020
VL 35
IS 6
BP 660
EP 670
DI 10.1093/arclin/acaa014
PG 11
WC Psychology, Clinical; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology
GA OW5NS
UT WOS:000592933700002
PM 32129455
OA Bronze
DA 2025-06-11
ER

PT J
AU Fichna, M
   Krzysko-Pieczka, I
   Zurawek, M
   Skowronska, B
   Januszkiewicz-Lewandowska, D
   Fichna, P
AF Fichna, Marta
   Krzysko-Pieczka, Izabela
   Zurawek, Magdalena
   Skowronska, Bogda
   Januszkiewicz-Lewandowska, Danuta
   Fichna, Piotr
TI &ITFKBP5&IT polymorphism is associated with insulin resistance in
   children and adolescents with obesity
SO OBESITY RESEARCH & CLINICAL PRACTICE
LA English
DT Article
DE Childhood obesity; FKBP5 gene; Polymorphism; Insulin resistance;
   Metabolic syndrome
ID BODY-MASS INDEX; ORAL GLUCOSE-TOLERANCE; SENSITIVITY INDEXES; METABOLIC
   SYNDROME; GLUCOCORTICOID-RECEPTOR; MAJOR DEPRESSION; PUBERTAL CHANGES;
   MESSENGER-RNA; FKBP5; CORTISOL
AB Objective: Since metabolic syndrome shares several clinical features with hypercortisolism, it was hypothesised that genes altering individual glucocorticoid (GC) sensitivity might be implicated in pathogenesis of obesity and its adverse outcomes. FKBP5 gene encodes a chaperon protein in the GC receptor (GR) complex, which modulates steroid action upon target genes. Its functional variant, rs1360780, may enhance FKBP5 gene transcription, affect GR signalling and thereby influence the hypothalamo-pituitary-adrenal axis. We investigated the association of rs1360780 with obesity and metabolic characteristics in 250 obese children and adolescents (mean age 12.3 +/- 3.6 years, BMI >= 95th percentile).& para;& para;Methods: Anthropometric measurements, body composition, biochemical and hormonal results were analysed. Genotyping of rs1360780 was compared with 568 lean controls.& para;& para;Results: Impaired fasting glucose was present in 8.8%, glucose intolerance in 10.4%, diabetes in 2.8% and dyslipidemia in 28.8% obese individuals. Hypertension was diagnosed in 34 out of 143 patients. No difference was found in FKBP5 polymorphism distribution between subjects with obesity and controls (p > 0.05). Stratification by rs1360780 revealed no differences in body mass and composition. However, carriers of the minor allele displayed enhanced insulin resistance (p = 0.009) and elevated serum triglyceride (p = 0.006), whereas cholesterol, HbA1c, and oral glucose challenge results were similar for all genotypes. Morning ACTH and cortisol did not differ but evening cortisol was higher in minor allele carriers (p=0.039), although this association was lost in logistic regression analysis.& para;& para;Conclusion: This study does not support the association of FKBP5 with obesity but demonstrates plausible implication of its variant in susceptibility to obesity-related insulin resistance and hypertriglyceridemia. (C) 2016 Published by Elsevier Ltd on behalf of Asia Oceania Association for the Study of Obesity.
C1 [Fichna, Marta] Poznan Univ Med Sci, Dept Endocrinol Metab & Internal Med, 49 Przybyszewskiego, PL-60355 Poznan, Poland.
   [Fichna, Marta; Zurawek, Magdalena; Januszkiewicz-Lewandowska, Danuta] Polish Acad Sci, Inst Human Genet, 32 Strzeszynska, PL-60479 Poznan, Poland.
   [Krzysko-Pieczka, Izabela; Skowronska, Bogda; Fichna, Piotr] Poznan Univ Med Sci, Dept Paediat Diabet & Obes, 27-33 Szpitalna, PL-60572 Poznan, Poland.
   [Januszkiewicz-Lewandowska, Danuta] Poznan Univ Med Sci, Dept Oncol Hematol & Bone Marrow Transplantat, 27-33 Szpitalna, PL-60572 Poznan, Poland.
C3 Poznan University of Medical Sciences; Polish Academy of Sciences;
   Institute of Human Genetics of the Polish Academy of Sciences; Poznan
   University of Medical Sciences; Poznan University of Medical Sciences
RP Fichna, M (corresponding author), Poznan Univ Med Sci, Dept Endocrinol Metab & Internal Med, 49 Przybyszewskiego, PL-60355 Poznan, Poland.
EM mfichna@man.poznan.pl
RI Januszkiewicz-Lewandowska, Danuta/AAE-2542-2020
OI Zurawek, Magdalena/0000-0002-0345-4054; Fichna,
   Marta/0000-0003-2865-7074; Skowronska, Bogda/0000-0002-5598-4858
FU Polish Diabetes Association
FX The study was supported by a research grant from the Polish Diabetes
   Association (awarded to M.F., 2013). We are grateful to the authorities
   and employees of the Regional Blood Transfusion Centre in Poznan for
   their invaluable help with control sample collection.
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NR 47
TC 16
Z9 16
U1 0
U2 4
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1871-403X
EI 1878-0318
J9 OBES RES CLIN PRACT
JI Obes. Res. Clin. Pract.
PD JAN-FEB
PY 2018
VL 12
IS 1
SU 1
BP 62
EP 70
DI 10.1016/j.orcp.2016.11.007
PG 9
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA GB6KC
UT WOS:000429177000007
PM 28007534
DA 2025-06-11
ER

PT J
AU Feng, L
   Chong, MS
   Lim, WS
   Lee, TS
   Collinson, SL
   Yap, P
   Ng, TP
AF Feng, Liang
   Chong, Mei Sian
   Lim, Wee Shiong
   Lee, Tih Shih
   Collinson, Simon L.
   Yap, Philip
   Tze Pin Ng
TI Metabolic Syndrome and Amnestic Mild Cognitive Impairment: Singapore
   Longitudinal Ageing Study-2 Findings
SO JOURNAL OF ALZHEIMERS DISEASE
LA English
DT Article
DE Amnestic mild cognitive impairment; APOE-epsilon 4; cognition; metabolic
   syndrome
ID CHINESE OLDER-ADULTS; BODY-MASS INDEX; RISK-FACTORS; APOLIPOPROTEIN-E;
   ALZHEIMERS-DISEASE; VASCULAR DEMENTIA; INSULIN-RESISTANCE; FOLLOW-UP;
   DECLINE; OBESITY
AB Metabolic syndrome (MetS) is reported to be associated with cognitive decline and dementia, in particular vascular dementia. However, the evidence linking MetS to Alzheimer's disease (AD) and amnestic mild cognitive impairment (aMCI), a precursor of AD, is inconsistent and limited. This study examined the association of MetS and its components with aMCI and how APOE-epsilon e4 and younger age influenced this association. Participants with aMCI (n = 98) and cognitively normal controls (n = 802) were identified from baseline data in a second wave cohort of older subjects aged 55 and over in the Singapore Longitudinal Ageing Study-2 (SLAS-2) in 2009/2010. The associations of MetS and its individual components with aMCI were analyzed using logistic regression controlling for age, gender, education, current smoking, alcohol drink, leisure time activities score, Geriatric Depression Scale score, APOE-epsilon 4, and heart disease or stroke. The analysis was repeated for associations stratified by age and APOE-epsilon 4 status. In multivariate analysis, MetS was associated with an elevated risk of aMCI (OR = 1.79; 95% CI 1.15-2.77). Among MetS components, central obesity showed a significant association with aMCI (OR = 1.77; 95% CI 1.11-2.82). The association between MetS and aMCI remained significant on repeated analysis among subjects free of heart disease and stroke. This association was particularly stronger among participants with APOE-epsilon 4 allele (OR = 3.35; 95% CI, 1.03-10.85) and younger (< 65 years) participants with APOE-epsilon 4 (OR = 6.57; 95% CI, 1.03-41.74). MetS was found to be associated with aMCI, especially in individuals with APOE-epsilon 4 at younger age in this middle-aged and older cohort.
C1 [Feng, Liang; Chong, Mei Sian; Lim, Wee Shiong; Lee, Tih Shih; Yap, Philip; Tze Pin Ng] Natl Univ Singapore, Yong Loo Lin Sch Med, Gerontol Res Programme, Singapore 119228, Singapore.
   [Feng, Liang; Tze Pin Ng] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Psychol Med, Singapore 119228, Singapore.
   [Chong, Mei Sian; Lim, Wee Shiong] Tan Tock Seng Hosp, Dept Geriatr Med, Singapore, Singapore.
   [Lee, Tih Shih] Duke NUS Grad Med Sch, Neurosci Program, Singapore, Singapore.
   [Collinson, Simon L.] Natl Univ Singapore, Dept Psychol, Singapore 119228, Singapore.
   [Yap, Philip] Alexandra Hosp, Dept Geriatr Med, Singapore, Singapore.
C3 National University of Singapore; National University of Singapore; Tan
   Tock Seng Hospital; National University of Singapore; National
   University of Singapore
RP Ng, TP (corresponding author), Natl Univ Singapore, Natl Univ Hosp, Dept Psychol Med, Gerontol Res Programme, NUHS Tower Block,9th Floor,1E Kent Ridge Rd, Singapore 119228, Singapore.
EM pcmngtp@nus.edu.sg
RI Collinson, Simon/HHZ-6965-2022; Chong, Mei Sian/A-4978-2013
OI Lim, Wee Shiong/0000-0003-3975-7230; Collinson, Simon
   Lowes/0000-0001-9232-9732; Chong, Mei Sian/0000-0001-9324-5901
FU Biomedical Research Council, Agency for Science, Technology and Research
   (A*STAR) [03/1/21/17/214]; Geylang East Home for the Aged; Presbyterian
   Community Services; Thye Hua Kwan Moral Society (Moral Neighbourhood
   Links); Yuhua Neighbourhood Link; Henderson Senior Citizens' Home; NTUC
   Eldercare Co-op Ltd; Thong Kheng Seniors Activity Centre (Queenstown
   Centre); Redhill Moral Seniors Activity Centre
FX The study is supported by a research grant (No. 03/1/21/17/214) from the
   Biomedical Research Council, Agency for Science, Technology and Research
   (A*STAR). We thank the following voluntary welfare organizations for
   their support of the Singapore Longitudinal Ageing Studies: Geylang East
   Home for the Aged, Presbyterian Community Services, Thye Hua Kwan Moral
   Society (Moral Neighbourhood Links), Yuhua Neighbourhood Link, Henderson
   Senior Citizens' Home, NTUC Eldercare Co-op Ltd, Thong Kheng Seniors
   Activity Centre (Queenstown Centre) and Redhill Moral Seniors Activity
   Centre.
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NR 69
TC 50
Z9 54
U1 1
U2 12
PU IOS PRESS
PI AMSTERDAM
PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS
SN 1387-2877
EI 1875-8908
J9 J ALZHEIMERS DIS
JI J. Alzheimers Dis.
PY 2013
VL 34
IS 3
BP 649
EP 657
DI 10.3233/JAD-121885
PG 9
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology
GA 104KK
UT WOS:000315991500008
PM 23246920
DA 2025-06-11
ER

PT J
AU Teasdale, S
   Mörkl, S
   Müller-Stierlin, AS
AF Teasdale, Scott
   Moerkl, Sabrina
   Mueller-Stierlin, Annabel Sandra
TI Nutritional psychiatry in the treatment of psychotic disorders: Current
   hypotheses and research challenges
SO BRAIN BEHAVIOR & IMMUNITY-HEALTH
LA English
DT Article
DE Nutritional psychiatry; Diet; Mental health; Gut -brain axis; Research
   challenges; Psychosis
ID SEVERE MENTAL-ILLNESS; GUT MICROBIOTA; VITAMIN-D; METABOLIC SYNDROME;
   BIPOLAR DISORDER; FOLATE LEVELS; SCHIZOPHRENIA; METAANALYSIS;
   INFLAMMATION; DIET
AB Current treatment for schizophrenia-spectrum disorders focusses primarily on psychotropic medication to treat symptoms, though their efficacy varies between patients and psychotropic medication is often accompanied by severe side effects. Nutritional interventions to prevent and treat mental illness have received considerable attention over recent years. However, evidence for nutritional interventions in schizophrenia-spectrum disorders remains limited in quantity and quality. Pathways currently in focus include: i) nutritional deficits and impairments in glucose metabolism, ii) inflammation and immune dysregulation (also known from the mild encephalitis hypothesis), and iii) altered gut microbiota. All of which appear to be interconnected. Key limiting factors for advancing research in this field are research challenges associated with assessing and interpreting inflammatory profiles, microbiota and subjective nutritional assessments, which is further complicated by illness characteristics. This review describes the state of evidence for key hypotheses, including underlying mechanisms, implicated in schizophrenia-spectrum disorders, the challenges in nutritional psychiatry research and the current state of nutrition interventions in mental healthcare.
C1 [Teasdale, Scott] Univ New South Wales Sydney, Sch Psychiat, Sydney, Australia.
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   [Mueller-Stierlin, Annabel Sandra] Univ Klinikum Ulm, Klin Psychiat & Psychotherapie 2, Ulm, Germany.
C3 University of New South Wales Sydney; Medical University of Graz; Ulm
   University
RP Müller-Stierlin, AS (corresponding author), Univ Ulm, Dept Psychiat 2, Ludwig Heilmeyer Str 2, D-89312 Gunzburg, Germany.
EM scott.teasdale@unswalumni.com; sabrina.moerkl@medunigraz.at;
   annabel.mueller-stierlin@uni-ulm.de
RI Teasdale, Scott/AFP-0676-2022; Mueller-Stierlin, Annabel/AAC-1241-2022
OI Mueller-Stierlin, Annabel Sandra/0000-0003-2812-5115; Teasdale,
   Scott/0000-0001-6769-8421
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NR 122
TC 28
Z9 30
U1 4
U2 7
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2666-3546
J9 BRAIN BEHAV IMMUN-HL
JI Brain Behav. Immun.-Health
PD MAY
PY 2020
VL 5
AR 100070
DI 10.1016/j.bbih.2020.100070
PG 9
WC Immunology; Neurosciences; Psychiatry
WE Emerging Sources Citation Index (ESCI)
SC Immunology; Neurosciences & Neurology; Psychiatry
GA R0LC8
UT WOS:001061332800003
PM 34589852
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Tang, WF
   Zhan, WQ
   Chen, Q
AF Tang, Weifeng
   Zhan, Wenqiang
   Chen, Qian
TI The mediating role of telomere length in multi-pollutant exposure
   associated with metabolic syndrome in adults
SO ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
LA English
DT Article
DE Multi-pollutant; Telomere length; Metabolic syndrome; Mediating effect
ID POLYCYCLIC AROMATIC-HYDROCARBONS; OXIDATIVE STRESS; DNA ADDUCTS;
   METHYLATION; ADIPOCYTES; PREVALENCE; MECHANISM; CHEMICALS; DAMAGE; CELLS
AB Metabolic syndrome is a chronic and complex disease characterized by environmental and genetic factors. However, the underlying mechanisms remain unclear. This study assessed the relationship between exposure to a mixture of environmental chemicals and metabolic syndrome (MetS) and further examined whether telomere length (TL) moderated these relationships. A total of 1265 adults aged > 20 years participated in the study. Data on multiple pollutants (polycyclic aromatic hydrocarbons, phthalates, and metals), MetS, leukocyte telomere length (LTL), and confounders were provided in the 2001-2002 National Health and Nutrition Examination Survey. The correlations between multi-pollutant exposure, TL, and MetS in the males and females were separately assessed using principal component analysis (PCA), logistic and extended linear regression models, Bayesian kernel machine regression (BKMR), and mediation analysis. Four factors were generated in PCA that accounted for 76.2% and 77.5% of the total environmental pollutants in males and females, respectively. The highest quantiles of PC2 and PC4 were associated with the risk of TL shortening (P < 0.05). We observed that the relationship between PC2, PC4, and MetS risk was significant in the participants with median TL levels (P for trend = 0.04 for PC2, and P for trend = 0.01 for PC4). Furthermore, mediation analysis revealed that TL could explain 26.1% and 17.1% of the effects of PC2 and PC4 associated with MetS in males, respectively. The results of BKMR model revealed that these associations were mainly driven by 1-PYE (cPIP = 0.65) and Cd (cPIP = 0.29) in PC2. Meanwhile, TL could explain 17.7% of the mediation effects of PC2 associated with MetS in the females. However, the relationships between pollutants and MetS were sparse and inconsistent in the females. Our findings suggest that the effects of the risk of MetS associated with mixed exposure to multiple pollutants are mediated by TL, and this mediating effect in the males is more pronounced than that in the females.
C1 [Tang, Weifeng; Zhan, Wenqiang; Chen, Qian] Shanghai Jiao Tong Univ, Xinhua Hosp, Shanghai Key Lab Childrens Environm Hlth, Minist Educ,Sch Med, Shanghai, Peoples R China.
   [Zhan, Wenqiang] Shanghai Jiao Tong Univ, Sch Publ Hlth, Sch Med, Shanghai, Peoples R China.
C3 Ministry of Education - China; Shanghai Jiao Tong University; Shanghai
   Jiao Tong University
RP Chen, Q (corresponding author), Shanghai Jiao Tong Univ, Xinhua Hosp, Shanghai Key Lab Childrens Environm Hlth, Minist Educ,Sch Med, Shanghai, Peoples R China.
EM chenqian01@xinhuamed.com.cn
FU National Natural Science Foundation of China [81803244]
FX This study was partially funded by the National Natural Science
   Foundation of China (81803244).
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NR 90
TC 0
Z9 0
U1 2
U2 15
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0944-1344
EI 1614-7499
J9 ENVIRON SCI POLLUT R
JI Environ. Sci. Pollut. Res.
PD JUL
PY 2023
VL 30
IS 34
BP 82068
EP 82082
DI 10.1007/s11356-023-28017-7
EA JUN 2023
PG 15
WC Environmental Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology
GA T9KN2
UT WOS:001011289600006
PM 37322399
DA 2025-06-11
ER

PT J
AU Goh, AMY
   Westphal, A
   Daws, T
   Gascoigne-Cohen, S
   Hamilton, B
   Lautenschlager, NT
AF Goh, Anita M. Y.
   Westphal, Alissa
   Daws, Teresa
   Gascoigne-Cohen, Sophie
   Hamilton, Bridget
   Lautenschlager, Nicola T.
TI A retrospective study of medical comorbidities in psychogeriatric
   patients
SO PSYCHOGERIATRICS
LA English
DT Article
DE ageing; comorbidities; medical illness; mental illness; psychogeriatric
ID CATIE SCHIZOPHRENIA TRIAL; SERIOUS MENTAL-ILLNESS;
   PSYCHIATRIC-INPATIENTS; METABOLIC SYNDROME; PHYSICAL ILLNESS; HEALTH;
   PREVALENCE; OBESITY; COMPLICATIONS; INDIVIDUALS
AB Background: This study contributes further research into the assessment and treatment of older psychiatric patients with medical comorbidities.
   Methods: A retrospective file audit was conducted at the acute inpatient psychogeriatric unit of St Vincent's Aged Mental Health Service, Melbourne, in order to determine the prevalence of certain medical comorbidities and the nature of medical interventions provided for psychogeriatric inpatients.
   Results: This study, investigating 165 admissions into an acute inpatient psychogeriatric unit, highlights that psychiatric and medical comorbidities are routine in this population: the vast majority (91.5%) of all inpatients had at least one medical comorbidity.
   Conclusions: As the population ages, psychogeriatric wards are likely to see more of the oldest-olds, who are likely to have comorbid medical illnesses. Currently, appropriate detection, investigation, and management of these illnesses are often suboptimal and can affect quality of life, increase mortality, and complicate treatment. This paper adds to the literature about the need for integrating medical and psychiatric care to create a more comprehensive strategy for treating the older person with psychiatric illness.
C1 [Goh, Anita M. Y.; Westphal, Alissa; Lautenschlager, Nicola T.] Univ Melbourne, Dept Psychiat, Acad Unit Psychiat Old Age, Melbourne, Vic, Australia.
   [Daws, Teresa; Hamilton, Bridget] Univ Melbourne, Dept Nursing, Melbourne, Vic, Australia.
   [Goh, Anita M. Y.; Gascoigne-Cohen, Sophie; Hamilton, Bridget; Lautenschlager, Nicola T.] St Vincents Hosp, St Vincents Aged Mental Hlth Serv, Melbourne, Vic, Australia.
   [Goh, Anita M. Y.] Royal Melbourne Hosp, Melbourne Neuropsychiat Ctr, Neuropsychiat Unit, Melbourne, Vic, Australia.
   [Lautenschlager, Nicola T.] Univ Western Australia, WA Ctr Hlth & Ageing, Sch Psychiat & Clin Neurosci, Perth, WA 6009, Australia.
C3 University of Melbourne; University of Melbourne; St Vincent's Health;
   St Vincent's Hospital Melbourne; NSW Health; St Vincents Hospital
   Sydney; Melbourne Health; Royal Melbourne Hospital; University of
   Western Australia
RP Goh, AMY (corresponding author), St George Hosp, Acad Unit Psychiat Old Age, Normanby Unit, 283 Cotham Rd, Kew, Vic 3101, Australia.
EM goha@unimelb.edu.au
RI Hamilton, Bridget/C-2788-2013; Goh, Anita/AAA-7278-2022
OI Lautenschlager, Nicola/0000-0003-4850-7794; Hamilton,
   Bridget/0000-0001-8711-7559; Goh, Anita/0000-0003-0159-5926
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NR 30
TC 10
Z9 10
U1 0
U2 12
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1346-3500
EI 1479-8301
J9 PSYCHOGERIATRICS
JI Psychogeriatrics
PD JAN
PY 2016
VL 16
IS 1
BP 12
EP 19
DI 10.1111/psyg.12111
PG 8
WC Geriatrics & Gerontology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology; Psychiatry
GA DH7ES
UT WOS:000372955400002
PM 25737391
DA 2025-06-11
ER

PT J
AU Shigehara, K
   Izumi, K
   Mizokami, A
   Namiki, M
AF Shigehara, Kazuyoshi
   Izumi, Koji
   Mizokami, Atsushi
   Namiki, Mikio
TI Testosterone Deficiency and Nocturia: A Review
SO WORLD JOURNAL OF MENS HEALTH
LA English
DT Review
DE Hypogonadism; Lower urinary tract symptoms; Nocturia; Testosterone
ID LOWER URINARY-TRACT; LATE-ONSET HYPOGONADISM; REPLACEMENT THERAPY; SERUM
   TESTOSTERONE; METABOLIC SYNDROME; SEX-HORMONES; MEN; SLEEP; SYMPTOMS;
   PROSTATE
AB Nocturia causes lack of sleep and excessive daytime somnolence, reducing overall well-being, vitality, productivity, and mental health. Nocturia is significantly associated with testosterone deficiency, lower urinary tract symptoms (LUTS), and sleep disorders. The development of LUTS is commonly associated with testosterone deficiency in elderly men, and recent studies have suggested that testosterone has an ameliorative effect on nocturia. In hypogonadal men with nocturia, a negative feedback cycle can arise, in which testosterone deficiency leads to the development of nocturia, and nocturia contributes to the decline in testosterone levels. Therefore, patients with nocturia should receive appropriate treatment in order to improve their quality of life. Nocturia is generally treated by restricting nighttime water intake, as well as by the administration of medications, such as alpha-1 blockers, anticholinergic drugs, and desmopressin. Testosterone replacement therapy (TRT) is used worldwide as a treatment for many hypogonadal conditions. TRT represents an alternative treatment option for nocturia in hypogonadal men. However, limited information is currently available regarding the effects of TRT on nocturia in hypogonadal men, and further studies are required to reach more definitive conclusions.
C1 [Shigehara, Kazuyoshi; Izumi, Koji; Mizokami, Atsushi; Namiki, Mikio] Kanazawa Univ, Grad Sch Med Sci, Dept Integrat Canc Therapy & Urol, 13-1 Takaramachi, Kanazawa, Ishikawa 9208641, Japan.
   [Namiki, Mikio] Hasegawa Hosp, Dept Urol, Toyama, Japan.
C3 Kanazawa University
RP Shigehara, K (corresponding author), Kanazawa Univ, Grad Sch Med Sci, Dept Integrat Canc Therapy & Urol, 13-1 Takaramachi, Kanazawa, Ishikawa 9208641, Japan.
EM kshigehara0415@yahoo.co.jp
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NR 47
TC 22
Z9 22
U1 0
U2 4
PU KOREAN SOC SEXUAL MEDICINE & ANDROLOGY
PI GWANGJU
PA DEPT UROLOGY, CHONNAM NATL UNIV MEDICAL SCH, 671 JEBONG-RO, DONG-GU,
   GWANGJU, 501-757, SOUTH KOREA
SN 2287-4208
EI 2287-4690
J9 WORLD J MENS HEALTH
JI World J. Mens Health
PD APR
PY 2017
VL 35
IS 1
BP 14
EP 21
DI 10.5534/wjmh.2017.35.1.14
PG 8
WC Andrology; Health Care Sciences & Services; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Health Care Sciences & Services; Urology &
   Nephrology
GA FJ8ID
UT WOS:000413007700002
PM 28459143
OA gold, Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Alonso, HRF
   Heimer, MV
   Calado, RV
   Silva, JVFD
   Lins, RML
   Romao, DA
   Pugliesi, DMC
   dos Santos, VE Jr
AF Alonso, Herculano Ramirez Floro
   Heimer, Monica Vilela
   Calado, Rafael Vrijdags
   Silva, Joao Victor Farias da
   Lins, Renata Matos Lamenha
   Romao, Dayse Andrade
   Pugliesi, Daniela Maria Carvalho
   dos Santos Junior, Valdeci Elias
TI Sedation and its Potential Risks in Children with Autism Spectrum Due to
   Drug Overlaps: A Critical Review
SO PESQUISA BRASILEIRA EM ODONTOPEDIATRIA E CLINICA INTEGRADA
LA English
DT Review
DE Mental Health; Autistic Disorder; Child Development; Pharmacology; Child
ID INDUCED QT PROLONGATION; TORSADE-DE-POINTES; SEROTONIN SYNDROME;
   RECEPTORS
AB Objective: To analyse pharmacological overlap in patients with autism spectrum disorder (ASD) under conscious sedation in a dental office environment, identifying any potential risks and complications. Material and Methods: A critical review was conducted by selecting articles from online databases (Pubmed and Lilacs), using a search algorithm and eligibility criteria. The Medscape (R) platform was used to verify interactions between drugs commonly used by patients with ASD and medications used for sedation in paediatric dentistry. Results: Due to their polydrug use, children with ASD are at risk of complications, namely Serotonin Syndrome (SS), Neuroleptic Malignant Syndrome (NMS), increase or decrease of the QT interval (QTi) and Torsade de Pointes (TdP), due to pre-existence of metabolic syndrome, deepening the sedation level or even leading to a decrease in the sedative capacity of the drugs used. Conclusion: It is essential to assess better drug interaction in ASD patients submitted to sedation. The severity of the disorder and the need for sedation for dental treatment are directly proportional. However, increases in sedative doses tend to increase risks and complications in children with ASD.
C1 [Alonso, Herculano Ramirez Floro; Calado, Rafael Vrijdags; Lins, Renata Matos Lamenha; Romao, Dayse Andrade; Pugliesi, Daniela Maria Carvalho; dos Santos Junior, Valdeci Elias] Univ Fed Alagoas, Sch Dent, Dept Pediat Dent, Maceio, AL, Brazil.
   [Heimer, Monica Vilela] Univ Pernambuco, Sch Dent, Dept Pediat Dent, Camaragibe, PE, Brazil.
   [Silva, Joao Victor Farias da] Univ Fed Sergipe, Dept Med, Aracaju, SE, Brazil.
C3 Universidade Federal de Alagoas; Universidade de Pernambuco (UPE);
   Universidade Federal de Sergipe
RP dos Santos, VE Jr (corresponding author), Univ Fed Alagoas, Sch Dent, Dept Pediat Dent, Maceio, AL, Brazil.
RI Lamenha-Lins, Renata/AAA-5920-2022; Heimer, Mônica/P-1135-2019
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NR 51
TC 0
Z9 0
U1 2
U2 3
PU ASSOC APOIO PESQUISA & SAUDE BUCAL-APESB
PI JOAO PESSOA
PA AGENCIA CIDADE UNIV, UNIV FEDERAL PARAIBA, CAMPUS I, JOAO PESSOA, PB
   58051-970, BRAZIL
SN 1519-0501
EI 1983-4632
J9 PESQUI BRAS ODONTOPE
JI Pesqui. Bras. Odontopediatria Clin. Integr.
PY 2024
VL 24
AR e220170
DI 10.1590/pboci.2024.053
PG 12
WC Dentistry, Oral Surgery & Medicine
WE Emerging Sources Citation Index (ESCI)
SC Dentistry, Oral Surgery & Medicine
GA PR8K4
UT WOS:001215899400001
DA 2025-06-11
ER

PT J
AU Argano, C
   Mirarchi, L
   Amodeo, S
   Orlando, V
   Torres, A
   Corrao, S
AF Argano, Christiano
   Mirarchi, Luigi
   Amodeo, Simona
   Orlando, Valentina
   Torres, Alessandra
   Corrao, Salvatore
TI The Role of Vitamin D and Its Molecular Bases in Insulin Resistance,
   Diabetes, Metabolic Syndrome, and Cardiovascular Disease: State of the
   Art
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE vitamin D; insulin resistance; metabolic syndrome; type 1 and 2
   diabetes; gestational diabetes; cardiovascular diseases and metabolism
ID RENIN-ANGIOTENSIN SYSTEM; 25-HYDROXYVITAMIN D LEVELS; BETA-CELL
   FUNCTION; D DEFICIENCY; D SUPPLEMENTATION; OXIDATIVE STRESS;
   1,25-DIHYDROXYVITAMIN D-3; GLYCEMIC CONTROL; BLOOD-PRESSURE; D-RECEPTOR
AB In the last decade, an increasing awareness was directed to the role of Vitamin D in non-skeletal and preventive roles for chronic diseases. Vitamin D is an essential hormone in regulating calcium/phosphorous balance and in the pathogenesis of inflammation, insulin resistance, and obesity. The main forms of vitamin D, Cholecalciferol (Vitamin D3) and Ergocalciferol (Vitamin D2) are converted into the active form (1,25-dihydroxyvitamin D) thanks to two hydroxylations in the liver, kidney, pancreas, and immune cells. Some anti-inflammatory cytokines are produced at higher levels by vitamin D, while some pro-inflammatory cytokines are released at lower levels. Toll-Like Receptor (TLR) expression is increased, and a pro-inflammatory state is also linked to low levels of vitamin D. Regardless of how it affects inflammation, various pathways suggest that vitamin D directly improves insulin sensitivity and secretion. The level of vitamin D in the body may change the ratio of pro- to anti-inflammatory cytokines, which would impact insulin action, lipid metabolism, and the development and function of adipose tissue. Many studies have demonstrated an inverse relationship between vitamin D concentrations and pro-inflammatory markers, insulin resistance, glucose intolerance, metabolic syndrome, obesity, and cardiovascular disease. It is interesting to note that several long-term studies also revealed an inverse correlation between vitamin D levels and the occurrence of diabetes mellitus. Vitamin D supplementation in people has controversial effects. While some studies demonstrated improvements in insulin sensitivity, glucose, and lipid metabolism, others revealed no significant effect on glycemic homeostasis and inflammation. This review aims to provide insight into the molecular basis of the relationship between vitamin D, insulin resistance, metabolic syndrome, type 1 and 2 diabetes, gestational diabetes, and cardiovascular diseases.
C1 [Argano, Christiano; Mirarchi, Luigi; Amodeo, Simona; Orlando, Valentina; Torres, Alessandra; Corrao, Salvatore] Natl Relevance & High Specializat Hosp Trust ARNAS, Dept Internal Med, I-90127 Palermo, Italy.
   [Corrao, Salvatore] Univ Palermo, Dept Hlth Promot Sci, Internal Med & Med Specialties, Maternal & Infant Care,PROMISE, I-90127 Palermo, Italy.
C3 University of Palermo
RP Argano, C (corresponding author), Natl Relevance & High Specializat Hosp Trust ARNAS, Dept Internal Med, I-90127 Palermo, Italy.
EM christiano.argano@arnascivico.it; luigi.mirarchi@arnascivico.it;
   simona.amodeo@arnascivico.it; valentina.orlando03@community.unipa.it;
   alessandra.torres1993@gmail.com; salvatore.corrao@unipa.it
RI Corrao, Salvatore/AAQ-5768-2020; Corrao, Salvatore/K-3504-2018
OI Corrao, Salvatore/0000-0001-5621-1374; Argano,
   Christiano/0000-0003-2662-8931
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NR 226
TC 55
Z9 58
U1 4
U2 15
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD OCT
PY 2023
VL 24
IS 20
AR 15485
DI 10.3390/ijms242015485
PG 26
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA X0EN7
UT WOS:001095271600001
PM 37895163
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Meyer, JA
AF Meyer, Jonathan M.
TI Strategies for the long-term treatment of schizophrenia: Real-world
   lessons from the CATIE trial
SO JOURNAL OF CLINICAL PSYCHIATRY
LA English
DT Article; Proceedings Paper
CT Teleconference on Evaluating the Evidence - Clinical Antipsychotic
   Trials of Intervention Effectiveness (CATIE)
CY MAY 10, 2006
CL ELECTR NETWORK
ID CLINICAL ANTIPSYCHOTIC TRIALS; METABOLIC SYNDROME; SUBSTANCE-ABUSE;
   HEPATITIS-B; DRUG-ABUSE; PREVALENCE; PEOPLE; HEALTH; REHABILITATION;
   RISK
AB Patients with schizophrenia have a chronic illness necessitating a biopsychosocial model of care that addresses the multiple dimensions of the disease, including coordinated primary care. Current research, including the lessons learned from the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) study, shows that in addition to education, adherence, and minimizing adverse effects of psychopharmacologic agents, multimodal long-term treatment strategies are needed to address medical comorbidities, substance abuse, and both cognitive and social deficits. Health care professionals have the responsibility to monitor and help prevent adverse medical outcomes related to treatment with antipsychotics, in light of evidence that patients with schizophrenia are at risk for metabolic disorders and are undertreated for highly prevalent cardiovascular risk factors. These medical problems are particularly challenging in this population due to the chronicity of symptoms, cognitive limitations, social and financial challenges, and compliance issues with recommended medication treatment and therapeutic lifestyle changes. Mental health providers in the United States are now studying models that support the integration of psychiatric and nonpsychiatric medical treatment to address the complexity of multimodal schizophrenia care.
C1 Univ Calif San Diego, Dept Psychiat, San Diego, CA 92161 USA.
C3 University of California System; University of California San Diego
RP Meyer, JA (corresponding author), Univ Calif San Diego, Dept Psychiat, 3350 La Jolla Village Dr 116A, San Diego, CA 92161 USA.
EM jmmeyer@ucsd.edu
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NR 49
TC 18
Z9 21
U1 0
U2 17
PU PHYSICIANS POSTGRADUATE PRESS
PI MEMPHIS
PA P O BOX 752870, MEMPHIS, TN 38175-2870 USA
SN 0160-6689
EI 1555-2101
J9 J CLIN PSYCHIAT
JI J. Clin. Psychiatry
PY 2007
VL 68
SU 1
BP 28
EP 33
PG 6
WC Psychology, Clinical; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI); Conference Proceedings Citation Index - Science (CPCI-S); Conference Proceedings Citation Index - Social Science &amp; Humanities (CPCI-SSH)
SC Psychology; Psychiatry
GA 134HR
UT WOS:000244074600005
PM 17286525
DA 2025-06-11
ER

PT J
AU Oh, SS
   Jang, JE
   Lee, DW
   Park, EC
   Jang, SI
AF Oh, Sarah Soyeon
   Jang, Ji-Eun
   Lee, Doo-Woong
   Park, Eun-Cheol
   Jang, Sung-In
TI Cigarette type or smoking history: Which has a greater impact on the
   metabolic syndrome and its components?
SO SCIENTIFIC REPORTS
LA English
DT Article
ID BLOOD-PRESSURE; RISK; ASSOCIATION; DEPRESSION; ADULTS
AB Few studies have researched the gender-specific effects of electronic nicotine delivery systems on the metabolic syndrome (MetS) and/or its risk factors (central obesity, raised triglycerides, decreased HDL cholesterol, raised blood pressure, raised fasting plasma glucose). Thus, this study investigated the association between smoking behavior (cigarette type, smoking history) and MetS in a nationally representative sample of Korean men and women. Our study employed data for 5,462 cases of MetS and 12,194 controls from the Korea National Health and Nutritional Examination Survey (KNHANES) for the years 2014 to 2017. Logistic regression analysis was employed to determine the association between type of cigarette (non-smoker, ex-smoker, and current smoker-conventional only, current smoker-conventional and electronic) and the prevalence of metabolic syndrome and its risk factors. Smoking history was clinically quantified by pack-year. No association between cigarette type and MetS was found for men. For women, relative to non-smokers, smokers of conventional cigarettes (OR 1.80, 95% CI 1.02-3.18) and both conventional and electronic cigarettes (OR 4.02, 95% CI 1.48-10.93) had increased odds of MetS. While there was no association between smoking history and MetS for women, for men, conventional smoking history was associated with MetS for individuals with a smoking history of>25 pack-years (>25 to <= 37.5 OR 1.45, 95% CI 1.04-2.02;>37.5 to <= 50 OR 1.53, 95% CI 1.08-2.18;>50 OR 1.56, 95% CI 1.07-2.27). Sex differences were found in the association between smoking behavior and MetS. Such findings reveal sociodemographic differences that should be considered for interventions regarding conventional and/or e-cigarette users at risk of metabolic complications.
C1 [Oh, Sarah Soyeon; Jang, Ji-Eun; Lee, Doo-Woong; Park, Eun-Cheol; Jang, Sung-In] Yonsei Univ, Coll Med, Inst Hlth Serv Res, Seoul, South Korea.
   [Oh, Sarah Soyeon; Lee, Doo-Woong] Yonsei Univ, Coll Med, Dept Publ Hlth, Grad Sch, Seoul, South Korea.
   [Park, Eun-Cheol; Jang, Sung-In] Yonsei Univ, Coll Med, Dept Prevent Med, Seoul, South Korea.
   [Jang, Ji-Eun] Ajou Univ, Coll Med, Dept Publ Hlth, Grad Sch, Seoul, South Korea.
C3 Yonsei University; Yonsei University Health System; Yonsei University;
   Yonsei University Health System; Yonsei University; Yonsei University
   Health System; Ajou University
RP Jang, SI (corresponding author), Yonsei Univ, Coll Med, Inst Hlth Serv Res, Seoul, South Korea.; Jang, SI (corresponding author), Yonsei Univ, Coll Med, Dept Prevent Med, Seoul, South Korea.
EM JANGSI@yuhs.ac
RI Park, Eun-Cheol/O-5644-2019; Lee, Doo Woong/IAL-9314-2023
OI Park, Eun-Cheol/0000-0002-2306-5398; Oh, Sarah/0000-0001-5709-2311;
   Jang, Sung-in/0000-0002-0760-2878; LEE, DOO WOONG/0000-0002-8843-2099
FU Yonsei University College of Medicine [6-2018-0174, 6-2017-0157]
FX This study was supported by a faculty research grant of Yonsei
   University College of Medicine (6-2018-0174 and 6-2017-0157).
CR [Anonymous], 2015, ELECT CIGARETTE USE
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NR 31
TC 30
Z9 31
U1 0
U2 1
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD JUN 26
PY 2020
VL 10
IS 1
AR 10467
DI 10.1038/s41598-020-67524-2
PG 8
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Science & Technology - Other Topics
GA MG3XQ
UT WOS:000545967200064
PM 32591636
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Howell, S
   Yarovova, E
   Khwanda, A
   Rosen, SD
AF Howell, Sandra
   Yarovova, Ekaterina
   Khwanda, Ahmad
   Rosen, Stuart D.
TI Cardiovascular effects of psychotic illnesses and antipsychotic therapy
SO HEART
LA English
DT Review
ID CLOZAPINE-INDUCED MYOCARDITIS; SEVERE MENTAL-ILLNESS; QTC-INTERVAL;
   RISK; SCHIZOPHRENIA; MORTALITY; DEATH; METAANALYSIS; DRUG;
   CARDIOMYOPATHY
AB Mortality from cardiovascular disease is increased in people with mental health disorders in general and schizophrenia in particular. The causes are multifactorial, but it is known that antipsychotic medication can cause cardiac side-effects beyond the traditional coronary risk factors. Schizophrenia itself is a contributor to an increased risk of cardiovascular mortality via cardiac autonomic dysfunction and a higher prevalence of metabolic syndrome, both contributing to a reduced life expectancy. The pro-arrhythmic impact of traditional antipsychotics, especially via the hERG-potassium channel, has been known for several years. Newer antipsychotics have a reduced pro-arrhythmic profile but might contribute to higher cardiac death rates by worsening the metabolic profile. Clozapine-induced cardiomyopathy, which is dose independent, is a further concern and continuous monitoring of these patients is required. Prophylaxis with angiotensin-converting enzyme inhibitors is currently under review. Overall, management of cardiovascular risk within this population group must be multifaceted and nuanced to allow the most effective treatment of serious mental illness to be conducted within acceptable parameters of cardiovascular risk; some practical measures are presented for the clinical cardiologist.
C1 [Howell, Sandra; Yarovova, Ekaterina; Rosen, Stuart D.] London North West Univ Healthcare NHS Trust, Ealing Hosp, Cardiol, London, Middx, England.
   [Yarovova, Ekaterina] Imperial Coll London, Fac Med, London, England.
   [Khwanda, Ahmad] Kings Coll Hosp NHS Fdn Trust, Cardiol, London, England.
   [Rosen, Stuart D.] Imperial Coll, Natl Heart & Lung Inst, Div Cardiovasc Sci, London SW7 2AZ, England.
C3 Imperial College London; King's College Hospital NHS Foundation Trust;
   Imperial College London
RP Rosen, SD (corresponding author), Imperial Coll, Natl Heart & Lung Inst, Div Cardiovasc Sci, London SW7 2AZ, England.
EM stuart.rosen@imperial.ac.uk
RI Rosen, Stuart/AAE-4649-2020
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NR 49
TC 52
Z9 55
U1 1
U2 11
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 1355-6037
EI 1468-201X
J9 HEART
JI Heart
PD DEC
PY 2019
VL 105
IS 24
BP 1852
EP 1859
DI 10.1136/heartjnl-2017-312107
PG 8
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Cardiovascular System & Cardiology
GA JX5UQ
UT WOS:000503800100005
PM 31439658
DA 2025-06-11
ER

PT J
AU Nishida, T
   Tsuneyama, K
   Fujimoto, M
   Nomoto, K
   Hayashi, S
   Miwa, S
   Nakajima, T
   Nakanishi, Y
   Sasaki, Y
   Suzuki, W
   Iizuka, S
   Nagata, M
   Shimada, T
   Aburada, M
   Shimada, Y
   Imura, J
AF Nishida, Takeshi
   Tsuneyama, Koichi
   Fujimoto, Makoto
   Nomoto, Kazuhiro
   Hayashi, Shinichi
   Miwa, Shigeharu
   Nakajima, Takahiko
   Nakanishi, Yuko
   Sasaki, Yoshiyuki
   Suzuki, Wataru
   Iizuka, Seiichi
   Nagata, Mitsunobu
   Shimada, Tsutomu
   Aburada, Masaki
   Shimada, Yutaka
   Imura, Johji
TI Spontaneous onset of nonalcoholic steatohepatitis and hepatocellular
   carcinoma in a mouse model of metabolic syndrome
SO LABORATORY INVESTIGATION
LA English
DT Article
DE animal model; hepatocellular carcinoma; inflammation; nonalcoholic
   steatohepatitis; obesity; oxidative stress; type-2 diabetes
ID FATTY LIVER-DISEASE; OBESE-DIABETIC MOUSE; ADIPOSE-TISSUE;
   GLUTAMINE-SYNTHETASE; INSULIN-RESISTANCE; ANIMAL-MODEL; PPAR-GAMMA;
   EXPRESSION; PIOGLITAZONE; INFLAMMATION
AB Metabolic syndrome is a worldwide healthcare issue and a dominant risk factor for the development of incurable diseases that affect the entire body. The hepatic manifestations of this syndrome include nonalcoholic fatty liver disease (NAFLD) and its progressive variant nonalcoholic steatohepatitis (NASH). The basic pathogenesis of NAFLD/NASH remains controversial because it is difficult to clarify the disease process of NASH on the basis of metabolic syndrome alone. To determine the pathogenesis and effective treatment, an excellent animal model of NASH is required. Tsumura Suzuki obese diabetes (TSOD) male mice spontaneously develop diabetes mellitus, obesity, glucosuria, hyperglycemia, and hyperinsulinemia without any special treatments such as gene manipulation. In this study, we examined the histopathological characteristics of visceral fat and liver of 56 male TSOD mice aged 4-17 months and 9 male Tsumura Suzuki non-obesity (control) mice aged 6-12 months. In the visceral fat, enlargement of adipocytes and perivascular and pericapsular CD8-positive lymphoid aggregation were observed in 4-month-old mice. Abnormal expression of tumor necrosis factor-a, interleukin-6, and lipid peroxidation endo products was observed in macrophages. In the liver, microvesicular steatosis, hepatocellular ballooning, and Mallory bodies were observed in 4-month-old mice, with severity worsening with increasing time. These pathological findings in the liver mimic those seen in patients with NASH. Interestingly, small liver nodules with high cellularity and absence of portal tracts were frequently observed after 12 months. Most of them showed nuclear and structural atypia, and mimicked human hepatocellular carcinoma. The degree of steatosis in the non-tumor portions of the liver improved when the liver nodules developed. These findings were not observed in control mice. Here, we report that TSOD male mice spontaneously developed NAFLD without any special treatment, and that these mice are a valuable model for assessing NASH and NASH carcinogenesis owing to metabolic syndrome. Laboratory Investigation (2013) 93, 230-241; doi:10.1038/labinvest.2012.155; published online 19 November 2012
C1 [Nishida, Takeshi; Tsuneyama, Koichi; Nomoto, Kazuhiro; Hayashi, Shinichi; Miwa, Shigeharu; Nakajima, Takahiko; Nakanishi, Yuko; Imura, Johji] Toyama Univ, Dept Diagnost Pathol, Grad Sch Med & Pharmaceut Sci, Toyama 9300194, Japan.
   [Fujimoto, Makoto; Shimada, Yutaka] Toyama Univ, Dept Japanese Oriental Med, Grad Sch Med & Pharmaceut Sci, Toyama 9300194, Japan.
   [Sasaki, Yoshiyuki; Suzuki, Wataru; Iizuka, Seiichi; Nagata, Mitsunobu; Shimada, Tsutomu; Aburada, Masaki] Musashino Univ, Pharmaceut Sci Res Inst, Fac Pharm, Tokyo, Japan.
   [Sasaki, Yoshiyuki] Inst Anim Reprod, Kasumigaura, Japan.
C3 University of Toyama; University of Toyama
RP Tsuneyama, K (corresponding author), Toyama Univ, Dept Diagnost Pathol, Grad Sch Med & Pharmaceut Sci, 2630 Sugitani, Toyama 9300194, Japan.
EM ktsune@med.u-toyama.ac.jp
OI Tsuneyama, Koichi/0000-0002-0670-9868
FU Japan Society for the Promotion Science [24390181, 21590433]; Takeda
   Science Foundation, Japan; TSOD Mouse Research Fund; Grants-in-Aid for
   Scientific Research [21590433, 24390181, 25460413] Funding Source: KAKEN
FX We thank Tokimasa Kumada, Hideki Hatta, and Chieko Kiya for their help
   and technical assistance in the experiments. We would also like to thank
   Yukari Inoue for her support during the preparation of this manuscript.
   We would like to express our appreciation to Dr Ulrich Deuschle (Phenex
   Pharmaceuticals AG, Germany) for his valuable advice. The project was
   supported in part by Grant-in Aid-for Scientific Research (B and C),
   Japan Society for the Promotion Science (24390181 and 21590433), Takeda
   Science Foundation, Japan (2010), and TSOD Mouse Research Fund.
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NR 43
TC 51
Z9 54
U1 0
U2 18
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 0023-6837
EI 1530-0307
J9 LAB INVEST
JI Lab. Invest.
PD FEB
PY 2013
VL 93
IS 2
BP 230
EP 241
DI 10.1038/labinvest.2012.155
PG 12
WC Medicine, Research & Experimental; Pathology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pathology
GA 084SF
UT WOS:000314558700009
PM 23212097
OA Bronze
DA 2025-06-11
ER

PT J
AU Zhang, RW
   Peng, L
   Cai, Q
   Xu, Y
   Liu, ZX
   Liu, YM
AF Zhang, Renwei
   Peng, Li
   Cai, Qi
   Xu, Yao
   Liu, Zhenxing
   Liu, Yumin
TI Development and validation of a predictive model for white matter
   lesions in young- and middle-aged people
SO FRONTIERS IN NEUROLOGY
LA English
DT Article
DE white matter lesions; carotid plaque score; diastolic blood pressure;
   metabolic syndrome; nomogram
ID SMALL VESSEL DISEASE; BLOOD-PRESSURE; RISK; HYPERINTENSITY; BRAIN;
   LEUKOARAIOSIS; ASSOCIATIONS; PREVALENCE; DEPRESSION; OBESITY
AB Background White matter lesion (WML) is an age-related disorder associated with stroke and cognitive impairment. This study aimed to investigate the risk factors and build a predictive model of WML in young- and middle-aged people.Methods We performed a second analysis of the data from the Dryad Digital Repository. We selected those people who are <60 years old and randomly divided them into the training group and the validation group. We investigated the risk factors of WML in the training group with logistic regression analysis and built a prediction nomogram based on multivariate logistic regression analysis; finally, the performance of the prediction nomogram was evaluated for discrimination, accuracy, and clinical utility.Results There were 308 people in the training group and 723 people in the validation group. Multivariate regression analysis showed that the age (OR = 1.49, 95% CI: 1.31-1.70), diastolic blood pressure (OR = 1.02, 95% CI: 1.00-1.03), carotid plaque score (OR = 1.31, 95% CI: 1.14-1.50), female gender (OR = 2.27, 95% CI: 1.56-3.30), and metabolic syndrome (OR = 2.12, 95% CI: 1.22-3.70) were significantly associated with white matter lesions. The area under the curve value (AUC) of the receiver operating curve (ROC) was 0.734 for the training group and 0.642 for the validation group. The calibration curve and clinical impact curve showed that the prediction nomogram has good accuracy and clinical application value.Conclusion Age, diastolic blood pressure, carotid plaque score, female gender, and metabolic syndrome were risk factors in young- and middle-aged people <60 years old with WML, and the nomogram based on these risk factors showed good discrimination, accuracy, and clinical utility.
C1 [Zhang, Renwei; Cai, Qi; Xu, Yao; Liu, Yumin] Wuhan Univ, Dept Neurol, Zhongnan Hosp, Wuhan, Peoples R China.
   [Peng, Li] Wuhan Univ, Zhongnan Hosp, Dept Cardiol, Wuhan, Peoples R China.
   [Liu, Zhenxing] Yiling Hosp Yichang, Dept Neurol, Yichang, Peoples R China.
C3 Wuhan University; Wuhan University
RP Liu, YM (corresponding author), Wuhan Univ, Dept Neurol, Zhongnan Hosp, Wuhan, Peoples R China.; Liu, ZX (corresponding author), Yiling Hosp Yichang, Dept Neurol, Yichang, Peoples R China.
EM 200432180216@whu.edu.cn; liuyumin9381@126.com
RI Liu, Zhenxing/GXH-9193-2022
FU The author(s) declare that no financial support was received for the
   research, authorship, and/or publication of this article.
FX The author(s) declare that no financial support was received for the
   research, authorship, and/or publication of this article.
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NR 38
TC 0
Z9 0
U1 1
U2 1
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2295
J9 FRONT NEUROL
JI Front. Neurol.
PD OCT 19
PY 2023
VL 14
AR 1257795
DI 10.3389/fneur.2023.1257795
PG 13
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA X1QX1
UT WOS:001096274700001
PM 37928162
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Das, A
   Nairn, S
AF Das, Aniruddha
   Nairn, Stephanie
TI Religious Attendance and Physiological Problems in Late Life
SO JOURNALS OF GERONTOLOGY SERIES B-PSYCHOLOGICAL SCIENCES AND SOCIAL
   SCIENCES
LA English
DT Article
DE Inflammation; Late life; Physiology; Religious attendance; Spousal loss;
   Weathering
ID CORONARY-HEART-DISEASE; C-REACTIVE PROTEIN; MENTAL-HEALTH; OLDER-ADULTS;
   PSYCHOLOGICAL DISTRESS; GENDER DIFFERENCES; MODERATED REGRESSION;
   DEPRESSIVE SYMPTOMS; ETHNIC-DIFFERENCES; METABOLIC SYNDROME
AB Objectives: This study queried linkages of older adults' religious attendance with their physiological health.
   Method: Data were from the 2005-2006 National Social Life, Health, and Aging Project, nationally representative of U.S. adults aged 57-85 years. Analyses examined associations of religious attendance with biological states, potential gender variations in these linkages, and attenuation by this factor of health effects of spousal loss.
   Results: Religious attendance was negatively associated with a system of physiological issues, consistent with mitigation of multisystemic "weathering." Linkages were relatively uniform with inflammatory and cardiovascular but not metabolic states and were not significantly different for women than men. Effects of spousal loss on the 2 former subsystems were attenuated by regular religious attendance-in combined-gender analysis and among women, but not men.
   Discussion: Religious attendance may buffer older adults from physiological problems and the health effects of life events such as spousal loss. More intensive analysis is needed to explain differential linkages with specific biological subsystems.
C1 [Das, Aniruddha; Nairn, Stephanie] McGill Univ, Dept Sociol, Room 712,Leacock Bldg,855 Sherbrooke St West, Montreal, PQ H3A 2T7, Canada.
   [Das, Aniruddha] McGill Univ, Ctr Populat Dynam, Montreal, PQ H3A 2T7, Canada.
C3 McGill University; McGill University
RP Das, A (corresponding author), McGill Univ, Dept Sociol, Room 712,Leacock Bldg,855 Sherbrooke St West, Montreal, PQ H3A 2T7, Canada.
EM aniruddha.das@mcgill.ca
RI Nairn, Stephanie/JQW-4646-2023
OI Nairn, Stephanie/0000-0002-6273-0290
CR Agresti A., 2007, INTRO CATEGORICAL DA
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NR 113
TC 19
Z9 20
U1 0
U2 4
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1079-5014
EI 1758-5368
J9 J GERONTOL B-PSYCHOL
JI J. Gerontol. Ser. B-Psychol. Sci. Soc. Sci.
PD MAR
PY 2016
VL 71
IS 2
BP 291
EP 308
DI 10.1093/geronb/gbu089
PG 18
WC Geriatrics & Gerontology; Gerontology; Psychology; Psychology,
   Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Psychology
GA DP0FD
UT WOS:000378163200010
PM 25098525
OA Bronze
DA 2025-06-11
ER

PT J
AU Bensenor, IM
AF Bensenor, I. M.
TI Thyroid disorders in Brazil: the contribution of the Brazilian
   Longitudinal Study of Adult Health (ELSA-Brasil)
SO BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
LA English
DT Article
DE Subclinical thyroid diseases; Hyperthyroidism; Hypothyroidism;
   Subclinical atherosclerosis; Cardiovascular diseases; Mental health
ID INTIMA-MEDIA THICKNESS; CORONARY-ARTERY CALCIFICATION; PULSE-WAVE
   VELOCITY; C-REACTIVE PROTEIN; CROSS-SECTIONAL ANALYSIS;
   HEART-RATE-VARIABILITY; GLOMERULAR-FILTRATION-RATE; CHRONIC
   KIDNEY-DISEASE; SERUM TSH LEVEL; SUBCLINICAL HYPOTHYROIDISM
AB Thyroid disorders are common diseases, both in Brazil and worldwide. The Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) is a prospective cohort study that investigates cardiovascular diseases, diabetes, and associated factors, including non-classical cardiovascular risk factors such as thyroid function. Thyroid function was classified according to thyrotropin stimulating hormone (TSH), free thyroxine (FT4), and use of medication to treat thyroid disorders, after excluding participants who reported use of any medication that could alter the results of the TSH and FT4 tests. All analyses included in this review are crosssectional using baseline data (2008 to 2010). The results showed an association of subclinical thyroid disorders with biomarkers of subclinical atherosclerosis, measured by carotid intima-media thickness and coronary artery calcium, insulin resistance, metabolic syndrome, and some psychiatric disorders. No association was found with the biomarker of inflammation high-sensitivity C-reactive protein, or changes in pulse wave velocity or heart rate variability.
C1 [Bensenor, I. M.] Univ Sao Paulo, Hosp Univ, Ctr Pesquisa Clin & Epidemiol, Sao Paulo, SP, Brazil.
   [Bensenor, I. M.] Univ Sao Paulo, Fac Med, Dept Clin Med, Sao Paulo, SP, Brazil.
C3 Universidade de Sao Paulo; Universidade de Sao Paulo
RP Bensenor, IM (corresponding author), Univ Sao Paulo, Hosp Univ, Ctr Pesquisa Clin & Epidemiol, Sao Paulo, SP, Brazil.; Bensenor, IM (corresponding author), Univ Sao Paulo, Fac Med, Dept Clin Med, Sao Paulo, SP, Brazil.
EM isabensenor@gmail.com
RI Bensenor, Isabela/L-3306-2017
OI Bensenor, Isabela/0000-0002-6723-5678
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NR 81
TC 2
Z9 2
U1 1
U2 7
PU ASSOC BRAS DIVULG CIENTIFICA
PI RIBEIRAO PRETO
PA FACULDADE MEDICINA, CASA 10, 14049 RIBEIRAO PRETO, RIBEIRAO PRETO, SP
   14049, BRAZIL
SN 0100-879X
EI 1678-4510
J9 BRAZ J MED BIOL RES
JI Brazilian J. Med. Biol. Res.
PY 2019
VL 52
IS 2
AR e8417
DI 10.1590/1414-431X20198417
PG 11
WC Biology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Life Sciences & Biomedicine - Other Topics; Research & Experimental
   Medicine
GA HM2DO
UT WOS:000459267400001
PM 30785482
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

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   older women
SO GERIATRIC NURSING
LA English
DT Article
DE Physical activity; Sedentary behavior; Mental health; Fear of falling;
   Community-dwelling older women
ID METABOLIC SYNDROME; RISK-FACTORS; PEOPLE; ADULTS; HEALTH; PERFORMANCE;
   INTENSITY; MORTALITY; MODERATE; OUTCOMES
AB This cross-sectional study aimed to examine the associations of objectively-measured physical activity (PA) and sedentary behavior (SB) patterns with fear of falling (FOF) in Chinese community-dwelling older women. Data from Physical Activity and Health in Older Women Study were analyzed for 1101 older women aged 60 to 70. Variables were demographics, objectively-measured PA, SB and FOF. Logistic regressions were conducted. All SB variables, light-intensity PA variable and bouted moderate-to-vigorous intensity PA (MVPA) were not associated with FOF. Total MVPA, sporadic MVPA and steps were independently associated with FOF. Multivariable-adjusted ORs in fully-adjusted models were 0.61, 0.59; 0.73, 0.62; 0.72, 0.59 for increasing tertiles of total MVPA time, sporadic MVPA time, and steps per day, respectively. The current finding which enables encourages PA in older women group could be complemented to maximize the overall level of potential public healthcare gains especially in community dwelling older population. (C) 2022 Elsevier Inc. All rights reserved.
C1 [Du, Litao; Zhang, Xianliang; He, Qiang; Li, Ting; Pan, Yang] Shandong Univ, Sch Phys Educ, 17922 Jingshi Rd, Jinan 250061, Shandong, Peoples R China.
   [Wang, Wenbo] Zaozhuang Vocat Coll Sci & Technol, Zaozhuang, Peoples R China.
   [Chen, Si] Shandong Univ, Cheeloo Coll Med, Sch Nursing & Rehabil, 44 West Wenhua Rd, Jinan 250102, Shandong, Peoples R China.
C3 Shandong University; Shandong University
RP Pan, Y (corresponding author), Shandong Univ, Sch Phys Educ, 17922 Jingshi Rd, Jinan 250061, Shandong, Peoples R China.; Chen, S (corresponding author), Shandong Univ, Cheeloo Coll Med, Sch Nursing & Rehabil, 44 West Wenhua Rd, Jinan 250102, Shandong, Peoples R China.
EM chensi@sdu.edu.cn; panyang@sdu.edu.cn
RI Du, Litao/IVU-6818-2023; Zhang, Xianliang/HTQ-1709-2023; Chen,
   Si/MGB-0660-2025
OI Chen, Si/0000-0002-6041-1528; Du, Litao/0000-0001-7296-7411; He,
   Qiang/0000-0002-7281-0200
FU Ministry of Education of Humanities and Social Science Project of China
   [19YJCZH255]; Fundamental Research Funds of Shandong University
   [2020GN064, 2020HW034]
FX This work was supported by the Ministry of Education of Humanities and
   Social Science Project of China under Grant 19YJCZH255; Fundamental
   Research Funds of Shandong University under Grant 2020GN064 and
   2020HW034.
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   World Health Organizatin, 2020, WHO guidelines on physical activity and sedentary behaviour
NR 44
TC 7
Z9 8
U1 8
U2 55
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0197-4572
EI 1528-3984
J9 GERIATR NURS
JI Geriatr. Nurs.
PD JUL-AUG
PY 2022
VL 46
BP 80
EP 85
DI 10.1016/j.gerinurse.2022.05.001
EA MAY 2022
PG 6
WC Geriatrics & Gerontology; Gerontology; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Nursing
GA 3F8EU
UT WOS:000830896300012
PM 35613487
DA 2025-06-11
ER

PT J
AU Puchau, B
   Zulet, MA
   de Echávarri, AG
   Navarro-Blasco, I
   Martínez, JA
AF Puchau, B.
   Zulet, M. A.
   Gonzalez de Echavarri, A.
   Navarro-Blasco, I.
   Martinez, J. A.
TI Selenium intake reduces serum C3, an early marker of metabolic syndrome
   manifestations, in healthy young adults
SO EUROPEAN JOURNAL OF CLINICAL NUTRITION
LA English
DT Article
DE inflammation; complement factor 3; oxidative stress; antioxidant;
   selenium; metabolic syndrome
ID ACYLATION-STIMULATING PROTEIN; POPULATION-BASED COHORT; TO-HEIGHT RATIO;
   INSULIN-RESISTANCE; COMPLEMENT C3; RISK-FACTOR; REACTIVE PROTEIN;
   ADIPOSE-TISSUE; PLASMA-LEVELS; MEN
AB Objectives: To evaluate the associations between serum complement factor 3 (C3) and several anthropometrical, biochemical and lifestyle features in healthy young adults, emphasizing on the putative effect of selenium intake on C3 concentrations.
   Methods: This study enrolled 100 healthy young adults aged 18-34 years. Anthropometric and blood pressure measurements and lifestyle features were analyzed. Fasting blood samples were collected for the measurement of glucose, total cholesterol, HDL-cholesterol, LDL-cholesterol, triacylglycerols and C3 concentrations. Nail samples were collected for the analysis of selenium concentrations.
   Results: Values of BMI (P = 0.034), sum of skinfold thicknesses (STs) (P = 0.021), body fat mass (BFM) (P = 0.023), percentage of overweight subjects (P = 0.007), serum triacylglycerols (P = 0.012) and nail selenium (P = 0.001) were significantly different between subjects above and below the median of serum C3 concentrations. The following correlations with serum C3 were identified tricipital ST (P = 0.033), sum of STs (P = 0.012), BMI (P = 0.008), BFM (P = 0.018), waist-to-height ratio (P = 0.016), serum glucose (P = 0.045), serum triacylglycerols (P = 0.001) and nail selenium (P = 0.006). Circulating C3 showed a positive association with several adiposity markers such as BMI (P = 0.001), waist circumference (P = 0.006), waist-to-height ratio (P = 0.002), BFM (P = 0.025), as well as serum glucose (P = 0.027) and triacylglycerols (P < 0.001), whereas nail selenium was a statistically significant negative predictor of C3 concentrations (P = 0.018).
   Conclusions: C3 seems to be related with selenium status and several anthropometrical and biochemical measurements linked to metabolic syndrome in apparently healthy young adults. These findings suggest a possible role for selenium intake in the modulation of C3, whose assessment may be an early marker of metabolic syndrome manifestations. European Journal of Clinical Nutrition (2009) 63, 858-864; doi:10.1038/ejcn.2008.48; published online 5 November 2008
C1 [Puchau, B.; Zulet, M. A.; Gonzalez de Echavarri, A.; Martinez, J. A.] Univ Navarra, Dept Nutr & Food Sci Physiol & Toxicol, Pamplona 31008, Spain.
   [Navarro-Blasco, I.] Univ Navarra, Dept Chem & Soil Sci, Pamplona 31008, Spain.
C3 University of Navarra; University of Navarra
RP Martínez, JA (corresponding author), Univ Navarra, Dept Nutr & Food Sci Physiol & Toxicol, Calle Irunlarrea 1, Pamplona 31008, Spain.
EM jalfmtz@unav.es
RI Martinez Hernandez, J Alfredo/K-8709-2014; Navarro-Blasco,
   Inigo/D-8148-2012; Zulet, M. Angeles/H-1317-2017
OI Martinez Hernandez, J Alfredo/0000-0001-5218-6941; Navarro-Blasco,
   Inigo/0000-0003-1863-0580; Zulet, M. Angeles/0000-0002-3926-0892
FU Linea Especial about Nutrition; Obesity and Health (LE/97); Health
   Department of the Government of Navarra(22/2007); University of Navarra
FX This study is supported by the Linea Especial about Nutrition, Obesity
   and Health (LE/97), the Health Department of the Government of
   Navarra(22/2007) and the ADA fellowships scheme of the University of
   Navarra. We thank Veronica Ciaurriz and Ana Lorente for technical
   assistance, Blanca Martinez de Morentin and Salome Perez for assistance
   with the data collection and all those who volunteered to participate in
   the study.
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NR 41
TC 44
Z9 46
U1 0
U2 3
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0954-3007
EI 1476-5640
J9 EUR J CLIN NUTR
JI Eur. J. Clin. Nutr.
PD JUL
PY 2009
VL 63
IS 7
BP 858
EP 864
DI 10.1038/ejcn.2008.48
PG 7
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 464MX
UT WOS:000267510300007
PM 18985060
DA 2025-06-11
ER

PT J
AU Sugawara, N
   Yasui-Furukori, N
   Yamazaki, M
   Shimoda, K
   Mori, T
   Sugai, T
   Matsuda, H
   Suzuki, Y
   Ozeki, Y
   Okamoto, K
   Sagae, T
   Someya, T
AF Sugawara, Norio
   Yasui-Furukori, Norio
   Yamazaki, Manabu
   Shimoda, Kazutaka
   Mori, Takao
   Sugai, Takuro
   Matsuda, Hiroshi
   Suzuki, Yutaro
   Ozeki, Yuji
   Okamoto, Kurefu
   Sagae, Toyoaki
   Someya, Toshiyuki
TI Predictive Utility of Body Mass Index for Metabolic Syndrome Among
   Patients with Schizophrenia in Japan
SO NEUROPSYCHIATRIC DISEASE AND TREATMENT
LA English
DT Article
DE body mass index; metabolic syndrome; schizoaffective disorder;
   schizophrenia
ID WAIST CIRCUMFERENCE; LIKELIHOOD RATIOS; MORTALITY; ABNORMALITIES;
   PREVALENCE; ANTIPSYCHOTICS; DYSREGULATION; DEPRESSION; NATIONWIDE;
   DISEASE
AB Background: Reliable and easy screening for metabolic syndrome (MetS) is important for patients with schizophrenia. The aim of this study was to assess the predictive utility of body mass index (BMI) for MetS among patients with schizophrenia in Japan.
   Methods: In total, 8468 patients (4705 males, 3763 females) with schizophrenia or schizoaffective disorders based on the Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM-IV), or the International Classification of Diseases, tenth revision (ICD-10), were assessed for MetS using the criteria of the National Cholesterol Education Program Adult Treatment Panel III (ATP III-A). We applied a stratum-specific likelihood ratio (SSLR) analysis, which is independent of the prevalence of the target disease.
   Results: The mean (+/- standard deviation) age of these patients was 57.4 +/- 13.5 years. The prevalence of MetS was 20.4%. Among males, the SSLRs predicting MetS were 0.03 (95% CI 0.02-0.06), 0.54 (95% CI 0.48-0.60), 2.77 (95% CI 2.44-3.14) and 8.75 (95% CI 7.40-10.36) for BMI <20 kg/m(2), 20 kg/m(2) <= BMI < 25 kg/m(2), 25 kg/m(2)<= BMI < 28 kg/ m(2), and 28 kg/m(2), and 28 kg/m(2)<= BMI, respectively. For females, the SSLRs predicting MetS were 0.08 (95% CI 0.05-0.12), 0.73 (95% CI 0.66-0.82), 2.50 (95% CI 2.16-2.90) and 4.83 (95% CI 4.12-5.67) for the same BMI categories, respectively.
   Conclusion: The predictive utility of BMI is confirmed, and BMI has more predictive value in males than in females. Patients with a BMI of 28 kg/m(2) or greater had a significantly higher SSLR than those with a BMI less than 28 kg/m(2).
C1 [Sugawara, Norio; Yasui-Furukori, Norio; Shimoda, Kazutaka] Dokkyo Med Univ, Dept Psychiat, Sch Med, 880 Kitakobayashi, Mibu, Tochigi 3210293, Japan.
   [Sugawara, Norio; Yasui-Furukori, Norio; Shimoda, Kazutaka; Sugai, Takuro; Suzuki, Yutaro; Ozeki, Yuji; Someya, Toshiyuki] Japanese Soc Clin Neuropsychopharmacol, Chiyoda Ku, Tokyo 1010003, Japan.
   [Yamazaki, Manabu; Mori, Takao; Matsuda, Hiroshi; Okamoto, Kurefu; Sagae, Toyoaki] Japan Psychiat Hosp Assoc, Minato Ku, Tokyo 1088554, Japan.
   [Sugai, Takuro; Suzuki, Yutaro; Someya, Toshiyuki] Niigata Univ, Grad Sch Med & Dent Sci, Dept Psychiat, Chuo Ku, Niigata 9518510, Japan.
   [Ozeki, Yuji] Shiga Univ Med Sci, Dept Psychiat, Otsu, Shiga 5202134, Japan.
   [Sagae, Toyoaki] Yamagata Prefectural Yonezawa Univ Nutr Sci, Dept Hlth & Nutr, Yonezawa, Yamagata 9920025, Japan.
C3 Dokkyo Medical University; Niigata University; Shiga University of
   Medical Science
RP Sugawara, N (corresponding author), Dokkyo Med Univ, Dept Psychiat, Sch Med, 880 Kitakobayashi, Mibu, Tochigi 3210293, Japan.
EM nsuga3@dokkyomed.ac.jp
RI Someya, Toshiyuki/ABD-1878-2021
OI Sugawara, Norio/0000-0001-7058-664X
FU Eisai Co., Ltd.; Yoshitomi Pharmaceutical Industries; Dainippon Sumitomo
   Pharma Co., Ltd.; Astellas Pharma Inc.; Meiji Seika Pharma Co., Ltd.;
   Eli Lilly Japan K.K.; Otsuka Pharmaceutical Co., Ltd.; GlaxoSmithKline
   K.K.; Janssen Pharmaceutical K.K.; MSD K.K.; Shionogi Co., Ltd.; Ono
   Pharmaceutical Co., Ltd.; Tsumura Co.; Asahi Kasei Pharma Corp.;
   Novartis Pharma Co., Ltd.; Takeda Pharmaceutical Co., Ltd.;
   Grants-in-Aid for Scientific Research [20H03597] Funding Source: KAKEN
FX This work was partially supported by Eisai Co., Ltd.; Yoshitomi
   Pharmaceutical Industries; Dainippon Sumitomo Pharma Co., Ltd.; Astellas
   Pharma Inc.; Meiji Seika Pharma Co., Ltd.; Eli Lilly Japan K.K.; Otsuka
   Pharmaceutical Co., Ltd.; GlaxoSmithKline K.K.; Janssen Pharmaceutical
   K.K.; MSD K.K.; Shionogi & Co., Ltd.; Asahi Kasei Pharma Corp.; Novartis
   Pharma Co., Ltd.; Takeda Pharmaceutical Co., Ltd.; Ono Pharmaceutical
   Co., Ltd.; and Tsumura & Co. The funders had no role in the study
   design, data collection and analysis, decision to publish, or
   preparation of the manuscript.
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NR 40
TC 7
Z9 7
U1 0
U2 2
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
EI 1178-2021
J9 NEUROPSYCH DIS TREAT
JI Neuropsychiatr. Dis. Treat.
PY 2020
VL 16
BP 2229
EP 2236
DI 10.2147/NDT.S269619
PG 8
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA NY8ZT
UT WOS:000576673900002
PM 33061393
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Shaw, J
   Anderson, T
AF Shaw, Jeffrey
   Anderson, Todd
TI Coronary endothelial dysfunction in non-obstructive coronary artery
   disease: Risk, pathogenesis, diagnosis and therapy
SO VASCULAR MEDICINE
LA English
DT Review
DE Cardiac syndrome X; chest pain syndromes; coronary artery disease;
   endothelial dysfunction; microvascular angina; NoCAD
ID CARDIAC SYNDROME-X; ISCHEMIA SYNDROME EVALUATION; SYNDROME EVALUATION
   WISE; CONVERTING ENZYME-INHIBITION; STABLE ANGINA-PECTORIS;
   CARDIOVASCULAR MAGNETIC-RESONANCE; INDUCED MYOCARDIAL-ISCHEMIA;
   LEFT-VENTRICULAR FUNCTION; EXERCISE-INDUCED ANGINA; ST SEGMENT
   DEPRESSION
AB Up to half of patients with signs and symptoms of stable ischemic heart disease have non-obstructive coronary artery disease (NoCAD). Recent evidence demonstrates that two-thirds of patients with NoCAD have demonstrable coronary endothelial dysfunction represented by microvascular or diffuse epicardial spasm following acetylcholine challenge. Patients with coronary endothelial dysfunction are recognized to have significant health services use and morbidity as well as increased risk of developing flow-limiting coronary artery disease and myocardial events, including death. Currently, there are few centers that test for this etiology owing to lack of knowledge, limited evidence for treatment options and invasive diagnostic strategies. This article reviews the pathophysiology, epidemiology, diagnosis and treatment of coronary endothelial dysfunction as a subgroup of NoCAD.
C1 [Shaw, Jeffrey; Anderson, Todd] Univ Calgary, Fac Med, Hlth Sci Ctr, Dept Cardiac Sci, 3330 Hosp Dr NW, Calgary, AB T2N 4N1, Canada.
C3 University of Calgary; University Calgary Hospital
RP Shaw, J (corresponding author), Univ Calgary, Fac Med, Hlth Sci Ctr, Dept Cardiac Sci, 3330 Hosp Dr NW, Calgary, AB T2N 4N1, Canada.
EM jashaw@ucalgary.ca
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NR 111
TC 37
Z9 40
U1 0
U2 15
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1358-863X
EI 1477-0377
J9 VASC MED
JI Vasc. Med.
PD APR
PY 2016
VL 21
IS 2
BP 146
EP 155
DI 10.1177/1358863X15618268
PG 10
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA DH6LB
UT WOS:000372901000009
PM 26675331
OA Bronze
DA 2025-06-11
ER

PT J
AU Yadav, D
   Mishra, M
   Joseph, AZ
   Subramani, SK
   Mahajan, S
   Singh, N
   Bisen, PS
   Prasad, GBKS
AF Yadav, Dhananjay
   Mishra, Meerambika
   Joseph, Anish Zacharia
   Subramani, Senthil Kumar
   Mahajan, Sunil
   Singh, Nita
   Bisen, Prakash Singh
   Prasad, G. B. K. S.
TI Status of antioxidant and lipid peroxidation in type 2 diabetic human
   subjects diagnosed with and without metabolic syndrome by using
   NCEP-ATPIII, IDF and WHO criteria
SO OBESITY RESEARCH & CLINICAL PRACTICE
LA English
DT Article
DE Metabolic syndrome; Catalase; Superoxide dismutase; Glutathione; Lipid
   peroxidation
ID OXIDATIVE STRESS; CARDIOVASCULAR-DISEASE; MELLITUS; COMPLICATIONS;
   PREDICTORS; ENZYME; ASSAY
AB Background: Antioxidants play a very crucial role in terms of disease incidence and its complications. Type 2 diabetes and metabolic syndrome (MetS) are now more prevalent than any other disorder. In this regard this study focuses on type 2 diabetic subjects with MetS having highest incidence of cardiovascular disease. Hence the aim of the study was to reveal the level of antioxidants and lipid peroxidation in MetS and non-MetS groups of type 2 diabetic subjects characterized by three different criteria.
   Methods: Present study was based on 70 type 2 diabetic subjects and 20 healthy controls. The metabolic syndrome criteria were defined by National Cholesterol Education Program (NCEP)-Adult Treatment Panel III (ATPIII), International Diabetes Federation (IDF), and World Health Organization (WHO). The selected subjects were of similar age group. The participants were selected from a diabetic camp being run in the University Campus. The antioxidant enzymes estimated were reduced glutathione (GSH), catalase (CAT), superoxide dismutase (SOD) while Thiobarbituric acid reactive substances (TBARS) measured as a marker of lipid peroxidation.
   Results: The level of GSH, CAT, SOD decreases in non-MetS and MetS subjects as compared to normal. When comparison was made for GSH & SOD in the mentioned groups resulted a significant differences in non-MetS and MetS compared with normal subjects. TBARS levels was increased in non-MetS and MetS group of subjects. The results indicate reduction in antioxidant enzymes and elevation of lipid peroxidation in type 2 diabetic subjects with or without MetS defined by using any of the International criteria.
   Conclusions: The study revealed that absolute reduction of antioxidant and involvement of lipid peroxidation in MetS group may lead to progressive intensification of cardiovascular disease in type 2 diabetic subjects irrespective of using any criteria. (C) 2014 Asian Oceanian Association for the Study of Obesity. Published by Elsevier Ltd. All rights reserved.
C1 [Yadav, Dhananjay] Yonsei Univ, Wonju Coll Med, Dept Internal Med, Wonju, South Korea.
   [Mishra, Meerambika] Sambalpur Univ, Sch Life Sci, Burla, Odisha, India.
   [Yadav, Dhananjay; Joseph, Anish Zacharia; Subramani, Senthil Kumar; Mahajan, Sunil; Singh, Nita; Bisen, Prakash Singh; Prasad, G. B. K. S.] Jiwaji Univ, SOS Biochem, Gwalior, Madhya Pradesh, India.
C3 Yonsei University; Sambalpur University; Jiwaji University Gwalior
RP Yadav, D (corresponding author), Yonsei Univ, Wonju Coll Med, Dept Internal Med, Wonju, South Korea.
EM dhanyadav16481@gmail.com
RI Mishra, Meerambika/AAH-6380-2020; KUMAR, SUNIL/ABG-7529-2022; Bisen,
   Prakash/H-3392-2019; Yadav, Dhananjay/AAZ-9435-2021
OI subramani, senthilkumar/0000-0001-5603-3002; Mishra,
   Meerambika/0000-0001-7124-7367; JOSEPH, ANISH
   ZACHARIA/0000-0003-0258-3820
CR [Anonymous], 2002, CIRCULATION
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NR 26
TC 11
Z9 12
U1 0
U2 9
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1871-403X
EI 1878-0318
J9 OBES RES CLIN PRACT
JI Obes. Res. Clin. Pract.
PD MAR-APR
PY 2015
VL 9
IS 2
BP 158
EP 167
DI 10.1016/j.orcp.2014.03.004
PG 10
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA CG1XJ
UT WOS:000353068500007
PM 25890429
DA 2025-06-11
ER

PT J
AU Taormina, JM
   Iwamoto, SJ
AF Taormina, John Michael
   Iwamoto, Sean J.
TI Filling a gap in care: addressing obesity in transgender and gender
   diverse patients
SO INTERNATIONAL JOURNAL OF OBESITY
LA English
DT Article
ID DISPARITIES
AB Transgender and gender diverse (TGD) adults are more likely to have obesity compared to cisgender peers. Based on surveys, the TGD population experiences disparities in healthy lifestyle behaviors (e.g., physical activity, screen time) compared to reference groups. They also face significant socioeconomic and healthcare barriers to accessing affirming care and gender minority stress, potentially contributing to increased weight. Gender-affirming hormone therapy is associated with changes in body composition and increased weight, which may impact cardiometabolic risk trajectory. Obesity can also be a barrier to gender-affirming surgeries, and affirming weight management services tailored to TGD patients are an important gap in healthcare to address. This Perspective briefly reviews current literature on the unique barriers experienced by TGD people and their identified needs regarding weight management interventions. It also suggests areas for future research to best fill this gap in healthcare and research while supporting the provision of lifesaving gender-affirming care.
C1 [Taormina, John Michael; Iwamoto, Sean J.] Univ Colorado, Sch Med, Anschutz Hlth & Wellness Ctr, Anschutz Med Campus, Aurora, CO 80045 USA.
   [Taormina, John Michael; Iwamoto, Sean J.] Univ Colorado, Sch Med, Dept Med, Div Endocrinol Metab & Diabet, Anschutz Med Campus, Aurora, CO 80045 USA.
   [Taormina, John Michael; Iwamoto, Sean J.] UCHlth Integrated Transgender Program, Aurora, CO 80045 USA.
   [Iwamoto, Sean J.] Eastern Colorado Hlth Care Syst, Rocky Mt Reg Vet Adm Med Ctr, Endocrinol Serv, Med Serv, Aurora, CO USA.
C3 University of Colorado System; University of Colorado Anschutz Medical
   Campus; University of Colorado System; University of Colorado Anschutz
   Medical Campus
RP Taormina, JM (corresponding author), Univ Colorado, Sch Med, Anschutz Hlth & Wellness Ctr, Anschutz Med Campus, Aurora, CO 80045 USA.; Taormina, JM (corresponding author), Univ Colorado, Sch Med, Dept Med, Div Endocrinol Metab & Diabet, Anschutz Med Campus, Aurora, CO 80045 USA.; Taormina, JM (corresponding author), UCHlth Integrated Transgender Program, Aurora, CO 80045 USA.
EM john.taormina@cuanschutz.edu
RI Taormina, John/LFT-4962-2024
OI Taormina, John/0009-0008-7060-3735; Iwamoto, Sean/0000-0002-7316-8256
FU Eunice Kennedy Shriver National Institute of Child Health amp; Human
   Development grant (The Colorado Building Interdisciplinary Research
   Careers in Women's Health [BIRCWH] Program) [5K12HD057022]
FX JMT has no financial disclosures. SJI receives funding & nbsp;&
   nbsp;through a Eunice Kennedy Shriver National Institute of Child Health
   & Human Development grant (The Colorado Building Interdisciplinary
   Research Careers in Women's Health [BIRCWH] Program; supported by
   5K12HD057022, PIs: Regensteiner JG and Santoro NF).
CR Bigarella LG, 2022, AESTHET SURG J, V42, P795, DOI 10.1093/asj/sjab397
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NR 17
TC 6
Z9 7
U1 0
U2 1
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0307-0565
EI 1476-5497
J9 INT J OBESITY
JI Int. J. Obes.
PD SEP
PY 2023
VL 47
IS 9
BP 761
EP 763
DI 10.1038/s41366-023-01334-0
EA JUL 2023
PG 3
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA P2AA8
UT WOS:001023393300001
PM 37414875
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Yang, SW
   Yang, HF
   Chen, YY
   Chen, WL
AF Yang, Shih-Wei
   Yang, Hui-Fang
   Chen, Yuan-Yuei
   Chen, Wei-Liang
TI Unraveling the link between metabolic syndrome and abdominal aortic
   calcification
SO NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
LA English
DT Article
DE Metabolic syndrome; Abdominal aortic; calcification; Atherosclerosis
ID CORONARY-HEART-DISEASE; OXIDATIVE STRESS; UNITED-STATES;
   ATHEROSCLEROSIS; MORBIDITY; MORTALITY; OBESITY; SCORE; RISK; SEX
AB Background & aims: Over the last few decades, the prevalence of metabolic syndrome (MetS) has gradually increased. As we know, many prior studies have connected MetS with diabetes, coronary heart disease, and cardiovascular disease. Abdominal aortic calcification (AAC) is a good marker of morbidity and mortality of vascular disease, as its degree may be associated with the severity of coronary artery calcification and disease. The aim of this article is to investigate the connection between MetS and AAC.
   Methods and results: This retrospective observational study included 2731 participants aged 58 years from the National Health and Nutrition Examination Survey (NHANES) (2013-2014). We used Dual-Energy X-ray Absorptiometry to define the degree of AAC. We defined MetS according to the National Cholesterol Education Program Adult Treatment Panel III definition.
   A total of 2731 participants with complete data were included for data analysis. In the fully adjusted model, an increase in the severity of AAC with the number of MetS components was still significant with beta values of AAC Total 24 Score 0.498 (95% confidence interval (CI): 0.018,0.978), 1.016 (95% CI: 0.514,1.519) and 1.426 (95% CI: 0.916,1.937) respectively in 2, 3 and >= 4 components. Additionally, associations were observed between MetS components, including blood pressure, HDL and glucose with beta values of AAC Total 24 Score 0.332(95% CI: 0.069, 0.595), 0.652(95% CI: 0.380, 0.925) and 0.534 (95% CI: 0.285, 0.783) after fully adjusted, respectively.
   Conclusion: The results indicated that, in the US adult population, a greater number of components of MetS were significantly associated with AAC. Among the components of metabolic syndrome, the blood pressure, HDL and blood sugar were observed apparent association with AAC. (C) 2020 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.
C1 [Yang, Shih-Wei] Triserv Gen Hosp, Dept Orthoped, Taipei, Taiwan.
   [Yang, Shih-Wei; Yang, Hui-Fang; Chen, Yuan-Yuei; Chen, Wei-Liang] Natl Def Med Ctr, Sch Med, Taipei, Taiwan.
   [Yang, Shih-Wei; Yang, Hui-Fang; Chen, Yuan-Yuei; Chen, Wei-Liang] Triserv Gen Hosp, Dept Family & Community Med, Div Family Med, Taipei, Taiwan.
   [Yang, Hui-Fang; Chen, Wei-Liang] Triserv Gen Hosp, Dept Family & Community Med, Div Geriatr Med, Taipei, Taiwan.
   [Chen, Yuan-Yuei] Triserv Gen Hosp, Dept Pathol, Songshan Branch, Taipei, Taiwan.
C3 Tri-Service General Hospital; National Defense Medical Center;
   Tri-Service General Hospital; Tri-Service General Hospital; Tri-Service
   General Hospital
RP Chen, WL (corresponding author), Triserv Gen Hosp, Natl Def Med Ctr, Dept Family Med, Div Geriatr Med, 325 Sect 2,Chang Gong Rd, Taipei 114, Taiwan.
EM weiliang0508@gmail.com
OI Yang, Hui-Fang/0000-0001-6400-0462
CR Azumi H, 2002, ARTERIOSCL THROM VAS, V22, P1838, DOI 10.1161/01.ATV.0000037101.40667.62
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NR 29
TC 26
Z9 27
U1 0
U2 9
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0939-4753
EI 1590-3729
J9 NUTR METAB CARDIOVAS
JI Nutr. Metab. Carbiovasc. Dis.
PD FEB 8
PY 2021
VL 31
IS 2
BP 464
EP 471
DI 10.1016/j.numecd.2020.10.003
EA FEB 2021
PG 8
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism; Nutrition
   & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism;
   Nutrition & Dietetics
GA QI3IN
UT WOS:000618872600013
PM 33223398
DA 2025-06-11
ER

PT J
AU Dupas, J
   Feray, A
   Guernec, A
   Pengam, M
   Inizan, M
   Guerrero, F
   Mansourati, J
   Goanvec, C
AF Dupas, Julie
   Feray, Annie
   Guernec, Anthony
   Pengam, Morgane
   Inizan, Manon
   Guerrero, Francois
   Mansourati, Jacques
   Goanvec, Christelle
TI Effect of personalized moderate exercise training on Wistar rats fed
   with a fructose enriched water
SO NUTRITION & METABOLISM
LA English
DT Article
DE Metabolic syndrome; Fructose enriched water rat model; Aerobic training
ID ADIPONECTIN-LEPTIN RATIO; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   MITOCHONDRIAL-FUNCTION; GLUCOSE-TOLERANCE; OXIDATIVE STRESS; RICH DIET;
   HEART; EXPRESSION; MUSCLE
AB Background: Metabolic Syndrom has become a public health problem. It mainly results from the increased consumption of fat and sugar. In this context, the benefits of personalized moderate exercise training were investigated on a metabolic syndrome male wistar rat model food with fructose drinking water (20-25% w/v). Different markers including body weight, metabolic measurements, blood biochemistry related to metabolic syndrome complications have been evaluated.
   Methods: Male Wistar rats were randomly allocated to 4 groups: control (sedentary (C, n = 8) and exercise trained (Ex, n = 8)), fructose fed (sedentary (FF, n = 8) and exercise trained fructose fed rats (ExFF, n = 10)). ExFF and Ex rats were trained at moderate intensity during the last 6 weeks of the 12 weeks-long protocol of fructose enriched water. Metabolic control was determined by measuring body weight, fasting blood glucose, HOMA 2-IR, HIRI, MISI, leptin, adiponectin, triglyceridemia and hepatic dysfunction.
   Results: After 12 weeks of fructose enriched diet, rats displayed on elevated fasting glycaemia and insulin resistance. A reduced food intake, as well as increased body weight, total calorie intake and heart weight were also observed in FF group. Concerning biochemical markers, theoretical creatinine clearance, TG levels and ASAT/ALAT ratio were also affected, without hepatic steatosis. Six weeks of 300 min/week of moderate exercise training have significantly improved overweight, fasting glycaemia, HOMA 2-IR, MISI without modify HIRI. Exercise also decreased the plasma levels of leptin, adiponectin and the ratio leptin/adiponectin. Regarding liver function and dyslipidemia, the results were less clear as the effects of exercise and fructose-enriched water interact together, and, sometimes counteract each other.
   Conclusion: Our results indicated that positive health effects were achieved through a personalized moderate training of 300 min per week (1 h/day and 5 days/week) for 6 weeks. Therefore, regular practice of aerobic physical exercise is an essential triggering factor to attenuate MetS disorders induced by excessive fructose consumption.
C1 [Dupas, Julie; Feray, Annie; Guernec, Anthony; Pengam, Morgane; Inizan, Manon; Guerrero, Francois; Mansourati, Jacques; Goanvec, Christelle] Univ Bretagne Occidentale, EA Optimisat Regulat Physiol 4324, 6 Ave Le Gorgeu, F-29238 Brest 3, France.
   [Inizan, Manon; Goanvec, Christelle] Univ Bretagne Occidentale, UFR Sci & Tech, 6 Ave Le Gorgeu, F-29237 Brest 3, France.
   [Feray, Annie; Guernec, Anthony; Guerrero, Francois] Univ Bretagne Occidentale, UFR Sci Sport & Educ, 20 Ave Le Gorgeu, F-29238 Brest 3, France.
   [Mansourati, Jacques] CHU Brest, Dept Cardiol, Blvd Tanguy Prigent, F-29200 Brest, France.
   [Feray, Annie; Guernec, Anthony; Pengam, Morgane; Inizan, Manon; Guerrero, Francois; Mansourati, Jacques; Goanvec, Christelle] IBSAM, UFR Med, Ave Camille Desmoulin, F-29200 Brest, France.
C3 Universite de Bretagne Occidentale; Universite de Bretagne Occidentale;
   Universite de Bretagne Occidentale; CHU Brest; Universite de Bretagne
   Occidentale
RP Goanvec, C (corresponding author), Univ Bretagne Occidentale, EA Optimisat Regulat Physiol 4324, 6 Ave Le Gorgeu, F-29238 Brest 3, France.; Goanvec, C (corresponding author), Univ Bretagne Occidentale, UFR Sci & Tech, 6 Ave Le Gorgeu, F-29237 Brest 3, France.
EM christelle.goanvec@univ-brest.fr
RI Mansourati, Jacques/HLQ-5147-2023
OI goanvec, christelle/0000-0002-1764-6778; Guerrero,
   Francois/0000-0002-0283-3503
FU Federation Francaise de Cardiologie
FX This study was partially funded by a research grant from the Federation
   Francaise de Cardiologie. Authors wish to acknowledge Nathalie
   GUEGUENIAT<SUP>1</SUP>, Jean L'HEGARET<SUP>1</SUP>, Stephane
   VIELLEDENT<SUP>3</SUP> and Charlene ALAIN<SUP>1</SUP> for the help they
   gave us in this project.
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NR 70
TC 8
Z9 8
U1 0
U2 2
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1743-7075
J9 NUTR METAB
JI Nutr. Metab.
PD OCT 3
PY 2018
VL 15
AR 69
DI 10.1186/s12986-018-0307-6
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA GV9VW
UT WOS:000446510800001
PM 30305835
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Coutinho, AE
   Campbell, JE
   Fediuc, S
   Riddell, MC
AF Coutinho, AE
   Campbell, JE
   Fediuc, S
   Riddell, MC
TI Effect of voluntary exercise on peripheral tissue glucocorticoid
   receptor content and the expression and activity of 11β-HSD1 in the
   Syrian hamster
SO JOURNAL OF APPLIED PHYSIOLOGY
LA English
DT Article
DE voluntary wheel running; corticosterone; metabolism; visceral fat; 11
   beta-hydroxysteroid dehydrogenase type 1
ID 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1; METABOLIC SYNDROME;
   CUSHINGS-DISEASE; SKELETAL-MUSCLE; OBESITY; STRESS; FAT; CORTICOSTERONE;
   HEPATOCYTES; CONTRIBUTE
AB Recent findings indicate that elevated levels of glucocorticoids (GC), governed by the expression of 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1) and GC receptors (GR), in visceral adipose tissue and skeletal muscle lead to increased insulin resistance and the metabolic syndrome. Paradoxically, evidence indicates that aerobic exercise attenuates the development of the metabolic syndrome even though it stimulates acute increases in circulating GC levels. To investigate the hypothesis that training alters peripheral GC action to maintain insulin sensitivity, young male hamsters were randomly divided into sedentary (S) and trained (T) groups (n = 8 in each). The T group had 24-h access to running wheels over 4 wk of study. In muscle, T hamsters had lower 11 beta-HSD1 protein expression (19.2 +/- 1.40 vs. 22.2 +/- 0.96 optical density, P < 0.05), similar 11 beta-HSD1 enzyme activity (0.9 +/- 0.27% vs. 1.1 +/- 0.26), and lower GR protein expression (9.7 +/- 1.86 vs. 15.1 +/- 1.78 optical density, P < 0.01) than S hamsters. In liver, 11 beta-HSD1 protein expression tended to be lower in T compared with S (19.2 +/- 0.56 vs. 21.4 +/- 1.05, P = 0.07), whereas both enzyme activity and GR protein expression were similar. In contrast, visceral adipose tissue contained similar to 2.7-fold higher 11 beta-HSD1 enzyme activity in T compared with S (12.9 +/- 3.3 vs. 4.8 +/- 1.5% conversion, P < 0.05) but was considerably smaller in mass (0.24 +/- 0.02 vs. 0.71 +/- 0.06 g). Thus the intracellular adaptation of GC regulators to exercise is tissue specific, resulting in decreases in GC action in skeletal muscle and increases in GC action in visceral fat. These adaptations may have important implications in explaining the protective effects of aerobic exercise on insulin resistance and other symptoms of the metabolic syndrome.
C1 York Univ, Dept Kinesiol & Hlth Sci, Toronto, ON M3J 2R7, Canada.
C3 York University - Canada
RP 347 Bethune Coll,4700 Keele St, Toronto, ON M3J 1P3, Canada.
EM mriddell@yorku.ca
OI Campbell, Jonathan/0000-0001-8223-1600
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NR 26
TC 37
Z9 44
U1 0
U2 1
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 8750-7587
EI 1522-1601
J9 J APPL PHYSIOL
JI J. Appl. Physiol.
PD MAY
PY 2006
VL 100
IS 5
BP 1483
EP 1488
DI 10.1152/japplphysiol.01236.2005
PG 6
WC Physiology; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology; Sport Sciences
GA 040DE
UT WOS:000237358400010
PM 16357069
DA 2025-06-11
ER

PT J
AU da Costa, RM
   da Silva, JF
   Alves, JV
   Dias, TB
   Rassi, DM
   Garcia, LV
   Lobato, ND
   Tostes, RC
AF da Costa, Rafael M.
   da Silva, Josiane F.
   Alves, Juliano V.
   Dias, Thiago B.
   Rassi, Diane M.
   Garcia, Luis V.
   Lobato, Nubia de Souza
   Tostes, Rita C.
TI Increased O-GlcNAcylation of Endothelial Nitric Oxide Synthase
   Compromises the Anti-contractile Properties of Perivascular Adipose
   Tissue in Metabolic Syndrome
SO FRONTIERS IN PHYSIOLOGY
LA English
DT Article
DE PVAT; O-GlcNAc; high-sugar diet; eNOS; vascular function
ID BETA-N-ACETYLGLUCOSAMINE; VASCULAR DYSFUNCTION; INSULIN-RESISTANCE;
   DIABETIC COMPLICATIONS; CARDIOVASCULAR-SYSTEM; LINKED GLYCOSYLATION;
   OXIDATIVE STRESS; OBESE MICE; ACTIVATION; PROTEINS
AB Under physiological conditions, the perivascular adipose tissue (PVAT) negatively modulates vascular contractility. This property is lost in experimental and human obesity and in the metabolic syndrome, indicating that changes in PVAT function may contribute to vascular dysfunction associated with increased body weight and hyperglycemia. The O-linked beta-N-acetylglucosamine (O-GlcNAc) modification of proteins (O-GlcNAcylation) is a unique posttranslational process that integrates glucose metabolism with intracellular protein activity. Increased flux of glucose through the hexosamine biosynthetic pathway and the consequent increase in tissue-specific O-GlcNAc modification of proteins have been linked to multiple facets of vascular dysfunction in diabetes and other pathological conditions. We hypothesized that chronic consumption of glucose, a condition that progresses tometabolic syndrome, leads to increased O-GlcNAcmodification of proteins in the PVAT, decreasing its anti-contractile effects. Therefore, the current study was devised to determine whether a high-sugar diet increases O-GlcNAcylation in the PVAT and how increased O-GlcNAc interferes with PVAT vasorelaxant function. To assess molecular mechanisms by which O-GlcNAc contributes to PVAT dysfunction, thoracic aortas surrounded by PVAT were isolated from Wistar rats fed either a control or high sugar diet, for 10 and 12 weeks. Rats chronically fed a high sugar diet exhibited metabolic syndrome features, increased O-GlcNAcylated-proteins in the PVAT and loss of PVAT anti-contractile effect. PVAT from high sugar diet-fed rats for 12 weeks exhibited decreased NO formation, reduced expression of endothelial nitric oxide synthase (eNOS) and increased O-GlcNAcylation of eNOS. High sugar diet also decreased OGA activity and increased superoxide anion generation in the PVAT. Visceral adipose tissue samples from hyperglycemic patients showed increased levels of O-GlcNAc-modified proteins, increased ROS generation and decreased OGA activity. These data indicate that O-GlcNAcylation contributes to metabolic syndrome-induced PVAT dysfunction and that O-GlcNAcylation of eNOS may be targeted in the development of novel therapies for vascular dysfunction in conditions associated with hyperglycemia.
C1 [da Costa, Rafael M.; da Silva, Josiane F.; Alves, Juliano V.; Dias, Thiago B.; Rassi, Diane M.; Tostes, Rita C.] Univ Sao Paulo, Dept Pharmacol, Ribeirao Preto Med Sch, Ribeirao Preto, Brazil.
   [Garcia, Luis V.] Univ Sao Paulo, Dept Biomech Med & Locomot Apparat Rehabil, Ribeirao Preto Med Sch, Ribeirao Preto, Brazil.
   [Lobato, Nubia de Souza] Univ Fed Goias, Inst Hlth Sci, Dept Physiol, Jatai, Brazil.
C3 Universidade de Sao Paulo; Universidade de Sao Paulo; Universidade
   Federal de Goias
RP da Costa, RM (corresponding author), Univ Sao Paulo, Dept Pharmacol, Ribeirao Preto Med Sch, Ribeirao Preto, Brazil.
EM rafael.menezess@yahoo.com.br
RI Silva, Josiane/AAM-9261-2020; Costa, Rafael/K-4606-2017; Garcia,
   Luis/L-4295-2014; Alves, Juliano/AAE-3541-2020; Tostes, Rita/C-1025-2012
OI Alves, Juliano Vilela/0000-0002-6555-5547; Menezes da Costa,
   Rafael/0000-0002-5174-5710; Silva, Josiane/0000-0002-6623-7946
FU Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP-CRID)
   [2013/08216-2]; Coordenacao de Aperfeicoamento de Pessoal de Nivel
   Superior (CAPES); Conselho Nacional de Desenvolvimento Cientifico e
   Tecnologico (CNPq), Brazil
FX This work was supported by grants from Fundacao de Amparo a Pesquisa do
   Estado de Sao Paulo (FAPESP-CRID 2013/08216-2 to RT), Coordenacao de
   Aperfeicoamento de Pessoal de Nivel Superior (CAPES), Conselho Nacional
   de Desenvolvimento Cientifico e Tecnologico (CNPq), Brazil.
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NR 42
TC 28
Z9 29
U1 1
U2 4
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-042X
J9 FRONT PHYSIOL
JI Front. Physiol.
PD APR 6
PY 2018
VL 9
AR 341
DI 10.3389/fphys.2018.00341
PG 16
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA GB9BV
UT WOS:000429369900001
PM 29681862
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Toblli, JE
   Cao, G
   Angerosa, M
   Rivero, M
AF Toblli, J. E.
   Cao, G.
   Angerosa, M.
   Rivero, M.
TI Long-term phosphodiesterase 5 inhibitor administration reduces
   inflammatory markers and heat-shock proteins in cavernous tissue of
   Zucker diabetic fatty rat (ZDF/fa/fa)
SO INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH
LA English
DT Article
ID ERECTILE DYSFUNCTION; METABOLIC SYNDROME; OXIDATIVE STRESS;
   CARDIOVASCULAR-DISEASE; NITRIC-OXIDE; ENDOTHELIAL FUNCTION;
   INSULIN-RESISTANCE; CORPORA CAVERNOSA; HYPERTENSIVE-RATS; ACE-INHIBITION
AB Oxidative Stress and nitrosative stress present in type 2 diabetes Mellitus (T2DM) and metabolic syndrome (MS) induce inflammatory response in diverse tissues including cavernous tissue (CT): Heat-Shock proteins (HSPs) have an important role in Modulating and repairing tissue injury, although their participation in CT in T2DM is unclear. Beyond the specific action of phosphodiesterase type 5 inhibitors (PDE5i) on erectile function, it has been proposed that chronic administration of these agents Improves endothelial function and ameliorates fibrotic changes. The aim of this study was to determine in CT of Zucker Diabetic Fatty (ZDF) rat, an experimental model of T2DM and MS: (1) the degree of oxidative stress and nitrosative stress; (2) the magnitude of inflammatory markers such as tumor necrosis factor-alpha (INF alpha) and interleukin 6 (IL6); (3) innmunoexpression of HSP70 and HSP27; (4) how a long-term PDE5i administration may modify these variables, For 6 Months,: (1) untreated ZDF; (2) ZDF+Sildenafil (Sil) and (3) control Lean Zucker Rat (LZR) received no treatment, were studied. Penises were processed for functional 'in vitro' studies, oxidative and nitrosative stress evaluation and Immunohistochemistry in CT using INF alpha; IL6; nitrotyrosine, HSP70 and HSP27 antibodies. ZDF+Sil presented better relaxation in Corporal strips versus untreated ZDF: Furthermore, ZDF+Sil presented less lipoperoxidation in CT versus untreated ZDF. The activity of antioxidant enzymes CuZn superoxide dismutase (CuZnSOD) and, glutathione peroxidase (GPx) was also reduced in untreated ZDF in CT along with a decrease in glutathione versus untreated ZDF. Nittotyrosine expression Was increased in untreated-ZDF rats versus ZDF+Sil and LZR. TNF alpha and IL6 were decreased in CT in ZDF+Sil versus Untreated ZDF. Additionally, the expression of HSP70 and HSP27 was reduced in CT in ZDP+Sil versus untreated ZDF. In Conclusion, this study provides substantial evidence stipporting a protective role a a long-term therapy With Sil on CT in a: recognized animal model of T2DM and MS.
C1 [Toblli, J. E.; Cao, G.; Angerosa, M.; Rivero, M.] Univ Buenos Aires, Expt Med Lab, Hosp Aleman, Sch Med, RA-1118 Buenos Aires, DF, Argentina.
C3 University of Buenos Aires; University of Buenos Aires Hospital;
   Hospital Aleman
RP Toblli, JE (corresponding author), Univ Buenos Aires, Expt Med Lab, Hosp Aleman, Sch Med, Ave Pueyrredon, RA-1118 Buenos Aires, DF, Argentina.
EM jorgetoblli@fibertel.com.ar
RI Cao, Gabriel/LJL-8755-2024
FU University of Buenos Aires (UBA); SLAMS grant
FX JET is a career investigator from Consejo Nacional de Investigaciones
   Cientificas y Tecnologicas of Argentina (CONICET) and received grant
   support from the University of Buenos Aires (UBA). We would like to
   thank to Ana Uceda and Mariana Feldman for their valuable technical
   support in the experiments, and Ms Jaquelina Mastantuono, who gently
   reviewed the style of this manuscript. This study was partially
   supported by the SLAMS grant for basic research.
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NR 59
TC 8
Z9 8
U1 1
U2 7
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0955-9930
EI 1476-5489
J9 INT J IMPOT RES
JI Int. J. Impot. Res.
PD SEP-OCT
PY 2015
VL 27
IS 5
BP 182
EP 190
DI 10.1038/ijir.2015.13
PG 9
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA CR1IU
UT WOS:000361079200005
PM 26202338
DA 2025-06-11
ER

PT J
AU Kim, JH
   Park, HY
   Bae, S
   Lim, YH
   Hong, YC
AF Kim, Jin Hee
   Park, Hye Yin
   Bae, Sanghyuk
   Lim, Youn-Hee
   Hong, Yun-Chul
TI Diethylhexyl Phthalates Is Associated with Insulin Resistance via
   Oxidative Stress in the Elderly: A Panel Study
SO PLOS ONE
LA English
DT Article
ID IN-UTERO EXPOSURE; DI(2-ETHYLHEXYL) PHTHALATE; TEMPORAL VARIABILITY;
   METABOLIC SYNDROME; NATIONAL-HEALTH; URINE SAMPLES; MISSING DATA; INDOOR
   AIR; MALE RATS; GLUCOSE
AB Background: Insulin resistance (IR) is believed to be the underlying mechanism of metabolic syndrome and type 2 diabetes mellitus (DM). Recently, a few studies have demonstrated that phthalates could cause oxidative stress which would contribute to the development of IR. Therefore, we evaluated whether exposure to phthalates affects IR, and oxidative stress is involved in the phthalates-IR pathway.
   Methods: We recruited 560 elderly participants, and obtained blood and urine samples during repeated medical examinations. For the determination of phthalate exposure, we measured urinary levels of mono-(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP) and mono-(2-ethyl-5-oxohexyl) phthalate (MEOHP) as metabolites of diethylhexyl phthalates (DEHP), and mono-n-butyl phthalate (MnBP) as a metabolite of di-butyl phthalate (DBP). Malondialdehyde (MDA), an oxidative stress biomarker, was also measured in urine samples. We measured serum levels of fasting glucose and insulin, and derived the homeostatic model assessment (HOMA) index to assess IR. A mixed-effect model and penalized regression spline were used to estimate the associations among phthalate metabolites, MDA, and IR.
   Results: The molar sum of MEHHP and MEOHP (Sigma DEHP) were significantly associated with HOMA (beta = 0.26, P = 0.040), and the association was apparent among participants with a history of DM (beta = 0.88, P = 0.037) and among females (beta = 0.30, P = 0.022). However, the relation between MnBP and HOMA was not found. When we evaluated whether oxidative stress is involved in increases of HOMA by Sigma DEHP, MDA levels were significantly associated with increases of Sigma DEHP (beta = 0.11, P < 0.001) and HOMA (beta = 0.49, P = 0.049).
   Conclusions: Our study results suggest that exposure to DEHP in the elderly population increases IR, which is related with oxidative stress, and that participants with a history of DM and females are more susceptible to DEHP exposure.
C1 [Kim, Jin Hee; Hong, Yun-Chul] Seoul Natl Univ, Inst Environm Med, Med Res Ctr, Seoul, South Korea.
   [Kim, Jin Hee; Bae, Sanghyuk; Hong, Yun-Chul] Seoul Natl Univ, Coll Med, Ctr Environm Hlth, Seoul, South Korea.
   [Park, Hye Yin; Bae, Sanghyuk; Hong, Yun-Chul] Seoul Natl Univ, Coll Med, Dept Prevent Med, Seoul, South Korea.
   [Lim, Youn-Hee] Seoul Natl Univ, Dept Epidemiol & Biostat, Sch Publ Hlth, Seoul, South Korea.
C3 Seoul National University (SNU); Seoul National University (SNU); Seoul
   National University (SNU); Seoul National University (SNU)
RP Hong, YC (corresponding author), Seoul Natl Univ, Inst Environm Med, Med Res Ctr, Seoul, South Korea.
EM ychong1@snu.ac.kr
RI Bae, Sanghyuk/AAQ-6635-2020; kim, jm/O-5935-2014; Hong,
   Yun-Chul/J-5725-2012
OI KIM, JIN HEE/0000-0003-1204-7079; Lim, Youn-Hee/0000-0002-1290-5814;
   Bae, Sanghyuk/0000-0002-4995-6543
FU Ministry of Environment, Republic of Korea
FX This study was supported by the Susceptible Population Research Program
   (2008-2010) of the Ministry of Environment, Republic of Korea. The
   funders had no role in study design, data collection and analysis,
   decision to publish, or preparation of the manuscript.
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NR 56
TC 102
Z9 113
U1 3
U2 43
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD AUG 19
PY 2013
VL 8
IS 8
AR e71392
DI 10.1371/journal.pone.0071392
PG 8
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 205ER
UT WOS:000323425700045
PM 23977034
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Green, KM
   Choi, JJ
   Ramchandran, RS
   Silverstein, SM
AF Green, Kyle M.
   Choi, Joy J.
   Ramchandran, Rajeev S.
   Silverstein, Steven M.
TI OCT and OCT Angiography Offer New Insights and Opportunities in
   Schizophrenia Research and Treatment
SO FRONTIERS IN DIGITAL HEALTH
LA English
DT Article
DE schizophrenia; OCT; angiography; retina; biomarker
ID NERVE-FIBER LAYER; CARDIOMETABOLIC RISK; THICKNESS; TRAJECTORIES;
   NEUROMOTOR; DISORDERS; STRESS
AB The human retina and retinal imaging technologies continue to increasingly gain the attention of schizophrenia researchers. With the same embryologic origin as the brain, the retina offers a window into neurovascular changes that may underlie disease. Recently, two technologies that have already revolutionized the field of ophthalmology, optical coherence tomography (OCT), and a functional extension of this, optical coherence tomography angiography (OCTA), have gained traction. Together, these non-invasive technologies allow for microscopic imaging of both structural and vascular features of the retina. With ease of use and no side effects, these devices are likely to prove powerful digital health tools in the study and treatment of schizophrenia. They may also prove key to discovering disease relevant biomarkers that underly neurodevelopmental and neurodegenerative aspects of conditions such as schizophrenia.
C1 [Green, Kyle M.; Ramchandran, Rajeev S.; Silverstein, Steven M.] Univ Rochester, Dept Ophthalmol, Med Ctr, Rochester, NY 14642 USA.
   [Choi, Joy J.; Silverstein, Steven M.] Univ Rochester, Dept Psychiat, Med Ctr, Rochester, NY 14642 USA.
   [Ramchandran, Rajeev S.] Univ Rochester, Dept Publ Hlth Sci, Med Ctr, Rochester, NY USA.
   [Silverstein, Steven M.] Univ Rochester, Dept Neurosci, Med Ctr, Rochester, NY 14642 USA.
   [Silverstein, Steven M.] Univ Rochester, Ctr Visual Sci, Rochester, NY 14642 USA.
C3 University of Rochester; University of Rochester; University of
   Rochester; University of Rochester; University of Rochester
RP Silverstein, SM (corresponding author), Univ Rochester, Dept Ophthalmol, Med Ctr, Rochester, NY 14642 USA.; Silverstein, SM (corresponding author), Univ Rochester, Dept Psychiat, Med Ctr, Rochester, NY 14642 USA.; Silverstein, SM (corresponding author), Univ Rochester, Dept Neurosci, Med Ctr, Rochester, NY 14642 USA.; Silverstein, SM (corresponding author), Univ Rochester, Ctr Visual Sci, Rochester, NY 14642 USA.
EM Steven_Silverstein@URMC.rochester.edu
OI Choi, Joy/0000-0003-4343-1356
FU New York Fund for Innovation in Research and Scientific Talent
   (NYFIRST), Center for Eye and Brain Health; Research to Prevent
   Blindness
FX Work on this paper was supported by a grant from the New York Fund for
   Innovation in Research and Scientific Talent (NYFIRST), Center for Eye
   and Brain Health to author SS, as well as an unrestricted grant from
   Research to Prevent Blindness to RR.
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NR 58
TC 6
Z9 8
U1 0
U2 3
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 2673-253X
J9 FRONT DIGIT HEALTH
JI Front. Digit. Health
PD FEB 18
PY 2022
VL 4
AR 836851
DI 10.3389/fdgth.2022.836851
PG 7
WC Health Care Sciences & Services; Medical Informatics
WE Emerging Sources Citation Index (ESCI)
SC Health Care Sciences & Services; Medical Informatics
GA M9FN0
UT WOS:001033199000001
PM 35252961
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Vogel, M
   Braungardt, T
   Meyer, W
   Schneider, W
AF Vogel, Matthias
   Braungardt, Tanja
   Meyer, Wolfgang
   Schneider, Wolfgang
TI The effects of shift work on physical and mental health
SO JOURNAL OF NEURAL TRANSMISSION
LA English
DT Review
DE Shift work; Desynchronization of circadian rhythms; Melatonin;
   Psychosocial implications of the working schedule
ID ISCHEMIC-HEART-DISEASE; PROSPECTIVE COHORT; METABOLIC SYNDROME; JOB
   DEMANDS; GASTROINTESTINAL DISORDERS; EXOGENOUS MELATONIN;
   DIABETES-MELLITUS; DECISION LATITUDE; EMPLOYMENT STATUS; SLEEP DISORDERS
AB Occupational engagement is a pre-requisite for continuous income opportunities. Among the changing social circumstances work-related conditions play an increasingly eminent role in psychological and mental well-being. The public discusses the question of a possible association between the demands of modern work life and the increases of psychological, psychosomatic and cardiovascular disorders. Given the socioeconomic implications of psychiatric and psychosomatic suffering in the general population, there is a need to further elucidate the causes of their increasing incidence. From a medical point of view, any organization of work disrupting the phased circadian rhythms for bio-psycho-social processes and functioning of the individual are interesting against the background of clock genes and certain biological functions that are organized in a circadian fashion. The authors review the influence of shift work as a form of systematic desynchronization of inner clock systems on the endocrine, the physical, and the mental level. The significance of the findings in the field is discussed along with future directions of conclusive research.
C1 [Vogel, Matthias; Braungardt, Tanja; Meyer, Wolfgang; Schneider, Wolfgang] Univ Rostock, Dept Psychosomat Med & Psychotherapy, D-18147 Rostock, Germany.
C3 University of Rostock
RP Schneider, W (corresponding author), Univ Rostock, Dept Psychosomat Med & Psychotherapy, Gehlsheimer Str 20, D-18147 Rostock, Germany.
EM wolfgang.schneider@med.uni-rostock.de
RI Vogel, Matthias/AAG-2529-2019
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NR 117
TC 128
Z9 149
U1 0
U2 81
PU SPRINGER WIEN
PI WIEN
PA SACHSENPLATZ 4-6, PO BOX 89, A-1201 WIEN, AUSTRIA
SN 0300-9564
EI 1435-1463
J9 J NEURAL TRANSM
JI J. Neural Transm.
PD OCT
PY 2012
VL 119
IS 10
SI SI
BP 1121
EP 1132
DI 10.1007/s00702-012-0800-4
PG 12
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 011RS
UT WOS:000309183200008
PM 22488445
DA 2025-06-11
ER

PT J
AU Rotenberg, S
   McGrath, JJ
AF Rotenberg, Sivan
   McGrath, Jennifer J.
TI Inter-relation between autonomic and HPA axis activity in children and
   adolescents
SO BIOLOGICAL PSYCHOLOGY
LA English
DT Article
DE Autonomic nervous system; Heart rate variability;
   Hypothalamic-pituitary-adrenal axis; Diurnal cortisol profile; Children;
   Adolescents; Perceived stress
ID HEART-RATE-VARIABILITY; CORTICOTROPIN-RELEASING HORMONE; SALIVARY
   CORTISOL; NEUROVISCERAL INTEGRATION; METHODOLOGICAL ISSUES; METABOLIC
   SYNDROME; IMMUNE-RESPONSES; FREQUENCY-DOMAIN; ALPHA-AMYLASE; VAGAL TONE
AB Stress research in youth typically considers either the autonomic nervous system or HPA axis. However, these systems are highly coordinated and physically interconnected. We examined whether the interrelation between cardio-autonomic and HPA axis measures was better associated with perceived stress than their singular associations. Children and adolescents (N=201) collected saliva samples to measure cortisol (AUC(AG), AUC(I), maximum), wore an electrocardiogram monitor for 24 h to derive heart rate variability (HRV; LF, HF, LF/HF ratio), and completed the Perceived Stress Scale. The interaction between sympathovagal modulation (LF, LF/HF ratio) and cortisol awakening response (AUC(AG), AUC(I), maximum) explained significantly greater variance in perceived stress than either stress system alone. Higher sympathovagal modulation combined with higher cortisol awakening response was associated with greater perceived stress. Findings suggest that the inter-relation between cardio-autonomic and HPA axis activity may advance our understanding of how stress impacts health. (C) 2016 Elsevier B.V. All rights reserved.
C1 [Rotenberg, Sivan; McGrath, Jennifer J.] Concordia Univ, Montreal, PQ H4B 1R6, Canada.
C3 Concordia University - Canada
RP McGrath, JJ (corresponding author), Concordia Univ, Pediat Publ Hlth Psychol Lab, Dept Psychol, 7141 Sherbrooke St West, Montreal, PQ H4B 1R6, Canada.
EM jennifer.mcgrath@concordia.ca
OI McGrath, Jennifer/0000-0003-1999-5047
FU Canadian Institutes of Health Research (CIHR) [MOP89886, OCO79897]; New
   Investigator Award [MSH95353]; Canada Graduate Scholarships Master's
   Award; Health Professional Student Research Award
FX We thank the participants and their families of the Healthy Heart
   Project, the teachers and principals of the Montreal English School
   Board, and the research assistants and study coordinators of the
   Pediatric Public Health Psychology Laboratory at Concordia University.
   Special thanks to Natasha Hunt, Sabrina Giovanniello, and Neressa Noel
   for their continued dedication. This work was made possible through
   funding support from the Canadian Institutes of Health Research (CIHR)
   Operating Grants (MOP89886 and OCO79897), New Investigator Award (J.J.
   McGrath MSH95353), Canada Graduate Scholarships Master's Award (S.
   Rotenberg), and Health Professional Student Research Award (S.
   Rotenberg).
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NR 97
TC 90
Z9 116
U1 0
U2 19
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0301-0511
EI 1873-6246
J9 BIOL PSYCHOL
JI Biol. Psychol.
PD MAY
PY 2016
VL 117
BP 16
EP 25
DI 10.1016/j.biopsycho.2016.01.015
PG 10
WC Psychology, Biological; Behavioral Sciences; Psychology; Psychology,
   Experimental
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Behavioral Sciences
GA DL5CE
UT WOS:000375654000003
PM 26835595
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Olgar, Y
   Turan, B
AF Olgar, Yusuf
   Turan, Belma
TI A sodium-glucose cotransporter 2 (SGLT2) inhibitor dapagliflozin
   comparison with insulin shows important effects on
   Zn<SUP>2+</SUP>-transporters in cardiomyocytes from insulin-resistant
   metabolic syndrome rats through inhibition of oxidative stress
SO CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
LA English
DT Article; Proceedings Paper
CT 6th Annual Meeting of the North-American-Section of the
   International-Academy-of-Cardiovascular-Sciences (Cardiology)
CY JUN 05-08, 2018
CL Havana, CUBA
SP Int Acad Cardiovascular Sci, N Amer Sect
DE diabetes; SGLT2 inhibitors; heart function; oxidative stress; matrix
   metalloproteins; heart
ID MATRIX METALLOPROTEINASES; EMPAGLIFLOZIN IMPROVES; EXPRESSION LEVELS;
   RETICULUM STRESS; HEART; DYSFUNCTION; OBESITY; HOMEOSTASIS; INDUCTION;
   INCREASE
AB Sodium-glucose cotransporter 2 (SGLT2) inhibitors showed significant effects in patients with diabetes or metabolic syndrome (MetS) with high cardiovascular risk. Although the increased intracellular Zn2+ level ([Zn2+](i)), oxidative stress, and altered cardiac matrix metalloproteinases (MMPs) in diabetic cardiomyopathy can intersect with different signaling pathways, the exact mechanisms are not known yet. Since either MMPs or SGLT2 have important roles in cardiac-fibrosis under hyperglycemia, we aimed to examine the role of SGLT2 inhibitor dapagliflozin (DAP) on cardiac Zn2+-transporters responsible for [Zn2+](i)-regulation, comparison to insulin (INS), together with MMP levels and systemic oxidative stress status in MetS-rats. High-carbohydrated diet-induced MetS-rats received DAP or INS for 2 weeks. DAP but not INS in MetS-rats significantly decreased high blood-glucose levels, while both treatments exerted benefits on increased total oxidative status and decreased total antioxidant status in MetS-rat plasma as well as in heart tissue. Protein levels of Zn2+-transporters, responsible for Zn2+-influx into cytosol, ZIP7 and ZIP14 were increased with significant decrease in ZIP8 of MetS-rat cardiomyoctes, while Zn2+-transporters, responsible for cytosolic Zn2+-efflux, ZnT7 was decreased with no change in ZnT8. Both treatments induced significant beneficial effects on altered ZIP14, ZIP8, and ZnT7 levels. Furthermore, both treatments exerted benefits on depressed gelatin-zymography and protein expression levels of MMP-2 and MMP-9 in MetS-rat ventricular cardiomyocytes. The direct effect of DAP on heart was also confirmed with measurements of left ventricular developed pressure. Overall, we showed that DAP has important antioxidant-like cardio-protective effects in MetS-rats, similar to INS-effect, affecting Zn2+-regulation via Zn2+-transporters, MMPs, and oxidative stress. Therefore one can suggest that SGLT2 inhibitors can be new therapeutic agents for cardio-protection not only in hyperglycemia but also in failing heart.
C1 [Olgar, Yusuf; Turan, Belma] Ankara Univ, Fac Med, Dept Biophys, Ankara, Turkey.
   [Olgar, Yusuf; Turan, Belma] Ankara Univ, Fac Med, Dept Internal Med, Ankara, Turkey.
C3 Ankara University; Ankara University
RP Turan, B (corresponding author), Ankara Univ, Fac Med, Dept Biophys, Ankara, Turkey.; Turan, B (corresponding author), Ankara Univ, Fac Med, Dept Internal Med, Ankara, Turkey.
EM belma.turan@medicine.ankara.edu.tr
RI olğar, yusuf/I-8960-2016; TURAN, Belma/AAG-8084-2020
OI TURAN, Belma/0000-0003-2583-9294; OLGAR, YUSUF/0000-0002-3226-7450
FU TUBITAK [SBAG-214S254]
FX The authors thank Erkan Tuncay and Sinan Degirmenci for their technical
   contribution to the study and Aysegul Durak for her help in caring for
   the experimental animals. This study was supported by TUBITAK
   SBAG-214S254 to BT.
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NR 47
TC 27
Z9 28
U1 0
U2 16
PU CANADIAN SCIENCE PUBLISHING
PI OTTAWA
PA 65 AURIGA DR, SUITE 203, OTTAWA, ON K2E 7W6, CANADA
SN 0008-4212
EI 1205-7541
J9 CAN J PHYSIOL PHARM
JI Can. J. Physiol. Pharmacol.
PD JUN
PY 2019
VL 97
IS 6
BP 528
EP 535
DI 10.1139/cjpp-2018-0466
PG 8
WC Pharmacology & Pharmacy; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Pharmacology & Pharmacy; Physiology
GA HZ9YH
UT WOS:000469213300011
PM 30444646
DA 2025-06-11
ER

PT J
AU Gliozzi, M
   Macri, R
   Coppoletta, AR
   Musolino, V
   Carresi, C
   Scicchitano, M
   Bosco, F
   Guarnieri, L
   Cardamone, A
   Ruga, S
   Scarano, F
   Nucera, S
   Mollace, R
   Bava, I
   Caminiti, R
   Serra, M
   Maiuolo, J
   Palma, E
   Mollace, V
AF Gliozzi, Micaela
   Macri, Roberta
   Coppoletta, Anna Rita
   Musolino, Vincenzo
   Carresi, Cristina
   Scicchitano, Miriam
   Bosco, Francesca
   Guarnieri, Lorenza
   Cardamone, Antonio
   Ruga, Stefano
   Scarano, Federica
   Nucera, Saverio
   Mollace, Rocco
   Bava, Irene
   Caminiti, Rosamaria
   Serra, Maria
   Maiuolo, Jessica
   Palma, Ernesto
   Mollace, Vincenzo
TI From Diabetes Care to Heart Failure Management: A Potential Therapeutic
   Approach Combining SGLT2 Inhibitors and Plant Extracts
SO NUTRIENTS
LA English
DT Review
DE diabetes; insulin resistance; lipid accumulation; inflammation; reactive
   oxygen species (ROS); SGLT2 inhibitors; nutraceutical supplementation;
   cardiovascular risk
ID INSULIN-RESISTANCE; ANTIOXIDANT STATUS; BERBERIS-VULGARIS; OXIDATIVE
   STRESS; M2 MACROPHAGES; PPAR-GAMMA; RATS; INFLAMMATION; MELLITUS;
   METAANALYSIS
AB Diabetes is a complex chronic disease, and among the affected patients, cardiovascular disease (CVD)is the most common cause of death. Consequently, the evidence for the cardiovascular benefit of glycaemic control may reduce long-term CVD rates. Over the years, multiple pharmacological approaches aimed at controlling blood glucose levels were unable to significantly reduce diabetes-related cardiovascular events. In this view, a therapeutic strategy combining SGLT2 inhibitors and plant extracts might represent a promising solution. Indeed, countering the main cardiometabolic risk factor using plant extracts could potentiate the cardioprotective action of SGLT2 inhibitors. This review highlights the main molecular mechanisms underlying these beneficial effects that could contribute to the better management of diabetic patients.
C1 [Gliozzi, Micaela; Macri, Roberta; Coppoletta, Anna Rita; Scicchitano, Miriam; Bosco, Francesca; Guarnieri, Lorenza; Cardamone, Antonio; Ruga, Stefano; Scarano, Federica; Nucera, Saverio; Mollace, Rocco; Bava, Irene; Caminiti, Rosamaria; Serra, Maria; Mollace, Vincenzo] Magna Graecia Univ Catanzaro, Dept Hlth Sci, Pharmacol Lab, Inst Res Food Safety & Hlth IRC FSH, I-88100 Catanzaro, Italy.
   [Musolino, Vincenzo; Maiuolo, Jessica] Magna Graecia Univ Catanzaro, Inst Res Food Safety & Hlth IRC FSH, Dept Hlth Sci, Pharmaceut Biol Lab, I-88100 Catanzaro, Italy.
   [Carresi, Cristina; Palma, Ernesto] Magna Graecia Univ Catanzaro, Inst Res Food Safety & Hlth IRC FSH, Dept Hlth Sci, Vet Pharmacol Lab, I-88100 Catanzaro, Italy.
   [Mollace, Vincenzo] Renato Dulbecco Inst, I-88046 Catanzaro, Italy.
C3 Magna Graecia University of Catanzaro; Magna Graecia University of
   Catanzaro; Magna Graecia University of Catanzaro
RP Musolino, V (corresponding author), Magna Graecia Univ Catanzaro, Inst Res Food Safety & Hlth IRC FSH, Dept Hlth Sci, Pharmaceut Biol Lab, I-88100 Catanzaro, Italy.; Carresi, C (corresponding author), Magna Graecia Univ Catanzaro, Inst Res Food Safety & Hlth IRC FSH, Dept Hlth Sci, Vet Pharmacol Lab, I-88100 Catanzaro, Italy.
EM v.musolino@unicz.it; carresi@unicz.it
RI Musolino, Vincenzo/AAC-6429-2022; MACRI', Roberta/AAC-5967-2022;
   Coppoletta, Annarita/LSK-7367-2024; Gliozzi, Micaela/D-4405-2015; serra,
   maria/LSJ-0107-2024; SCARANO, FEDERICA/HNC-2414-2023; Cardamone,
   Antonio/HGA-5612-2022; carresi, cristina/AAC-6354-2022; Mollace,
   Rocco/ABH-5643-2020; nucera, saverio/AAC-6570-2022; Maiuolo,
   Jessica/AAU-2482-2020; Ruga, Stefano/JUV-6384-2023; Palma,
   ERNESTO/KRP-9299-2024
OI Mollace, Rocco/0000-0002-7106-5595; mollace,
   vincenzo/0000-0002-0392-7173; Guarnieri, Lorenza/0009-0007-5865-8779;
   Bosco, Francesca/0009-0004-4766-9710; Ruga, Stefano/0009-0008-0401-4027;
   SCARANO, FEDERICA/0000-0002-9838-9469; Musolino,
   Vincenzo/0000-0002-4763-2211; carresi, cristina/0000-0002-3509-5930;
   PALMA, Ernesto/0000-0003-4199-207X; serra, maria/0009-0005-7736-2207;
   Coppoletta, Anna Rita/0009-0000-5576-1139; MACRI',
   Roberta/0000-0002-2345-6751; Cardamone, Antonio/0000-0002-9091-1806
FU Italian Ministry of Research; POR Calabria FESR 2014-2020-PON-MIUR
   [03PE000_78_1]; PONMIUR [03PE000_78_2]; PRIR Calabria Asse 1/Azione
   1.5.1/FESR (Progetto AgrInfra Calabria)
FX The work was supported by public resources from the Italian Ministry of
   Research and POR Calabria FESR 2014-2020-PON-MIUR 03PE000_78_1 and
   PONMIUR 03PE000_78_2. PRIR Calabria Asse 1/Azione 1.5.1/FESR (Progetto
   AgrInfra Calabria).
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NR 110
TC 10
Z9 10
U1 1
U2 2
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD SEP
PY 2022
VL 14
IS 18
AR 3737
DI 10.3390/nu14183737
PG 16
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 4U6VK
UT WOS:000858928900001
PM 36145112
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Haghighi, M
   Barikani, R
   Jahangard, L
   Ahmadpanah, M
   Bajoghli, H
   Bahmani, DS
   Holsboer-Trachsler, E
   Brand, S
AF Haghighi, Mohammad
   Barikani, Reza
   Jahangard, Leila
   Ahmadpanah, Mohammad
   Bajoghli, Hafez
   Bahmani, Dena Sadeghi
   Holsboer-Trachsler, Edith
   Brand, Serge
TI Levels of mania and cognitive performance two years after ECT in
   patients with bipolar I disorder - results from a follow-up study
SO COMPREHENSIVE PSYCHIATRY
LA English
DT Article
ID ELECTROCONVULSIVE-THERAPY; METABOLIC SYNDROME; SUICIDAL-BEHAVIOR; MAJOR
   DEPRESSION; SODIUM VALPROATE; HCL-32; ADOLESCENTS; IMPAIRMENT;
   CONSORTIUM; INVENTORY
AB Background: There is limited evidence on the long-term outcomes for patients with bipolar I disorder (BP-I-D) and treated with ECT. Therefore, we asked whether mania scores and cognitive performance at the end of ECT treatment (baseline/BL) predicted mania scores, cognitive performance, recurrence, treatment adherence, and mood (depression; hypomania) two years later (follow-up/FU).
   Method: 38 patients with BP-I-D undergoing ECT at baseline were followed up two years later. A brief psychiatric and cognitive assessment (Mini Mental State Examination; short-term verbal memory test) was performed; patients completed questionnaires covering recurrence, treatment adherence, and mood (depression; hypomania).
   Results: High cognitive performance at BL predicted high cognitive performance at FU; low mania scores at BL predicted low mania scores at FU. By FU, cognitive performance had increased and mania scores decreased. Mania scores and cognitive performance at BL did not predict recurrence, or adherence to medication, or mood (depression; hypomania).
   Conclusions: The pattern of results suggests that after two years of successful treatment of acute mania with ECT, cognitive impairment, measured by MMSE and a short-term verbal memory test, is not impaired and mood symptom recurrence seems to be improved. Mania scores and cognitive performance at the end of ECT treatment predicted neither mood (depression; hypomania), nor recurrence, or adherence to medication two years later. (C) 2016 Elsevier Inc. All rights reserved.
C1 [Haghighi, Mohammad; Barikani, Reza; Jahangard, Leila; Ahmadpanah, Mohammad] Hamadan Univ Medial Sci, Res Ctr Behav Disorders & Subst Abuse, Hamadan, Iran.
   [Bajoghli, Hafez] Tehran Univ Medial Sci, Iranian Inst Reduct High Risk Behav, Iranian Natl Ctr Addict Studies INCAS, Tehran, Iran.
   [Bahmani, Dena Sadeghi; Holsboer-Trachsler, Edith; Brand, Serge] Univ Basel, Psychiat Clin, Ctr Affect Stress & Sleep Disorders, Wilhelm Klein Str 27, CH-4012 Basel, Switzerland.
   [Brand, Serge] Univ Basel, Dept Sport Exercise & Hlth, Basel, Switzerland.
C3 University of Basel; University of Basel; Swiss School of Public Health
   (SSPH+)
RP Brand, S (corresponding author), Univ Basel, Psychiat Clin, Ctr Affect Stress & Sleep Disorders, Wilhelm Klein Str 27, CH-4012 Basel, Switzerland.
EM serge.brand@upkbs.ch
RI Bahmani, Dena/H-8271-2019; Brand, Serge/H-7159-2019; ahmadpanah,
   mohammad/U-6860-2017; Jahangard, Leila/R-4159-2017; Haghighi,
   Mohammad/R-3453-2017
OI ahmadpanah, mohammad/0000-0003-2908-2460; Jahangard,
   Leila/0000-0002-2834-4644; Brand, Serge/0000-0003-2175-2765; Haghighi,
   Mohammad/0000-0002-4875-1036
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NR 37
TC 9
Z9 12
U1 0
U2 13
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0010-440X
EI 1532-8384
J9 COMPR PSYCHIAT
JI Compr. Psychiat.
PD AUG
PY 2016
VL 69
BP 71
EP 77
DI 10.1016/j.comppsych.2016.05.009
PG 7
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA DS1WS
UT WOS:000380416400009
PM 27423347
DA 2025-06-11
ER

PT J
AU Lakhani, HV
   Zehra, M
   Pillai, SS
   Puri, N
   Shapiro, JI
   Abraham, NG
   Sodhi, K
AF Lakhani, Hari Vishal
   Zehra, Mishghan
   Pillai, Sneha S.
   Puri, Nitin
   Shapiro, Joseph I.
   Abraham, Nader G.
   Sodhi, Komal
TI RETRACTED: Beneficial Role of HO-1-SIRT1 Axis in Attenuating Angiotensin
   II-Induced Adipocyte Dysfunction (Retracted article. See vol. 22, 2021)
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article; Retracted Publication
DE angiotensin II; mineralocorticoid receptor; heme oxygenase 1; sirtuin 1;
   adipocytes; oxidative stress
ID IMPROVES INSULIN SENSITIVITY; HEME OXYGENASE; ADIPOSE-TISSUE;
   MINERALOCORTICOID RECEPTOR; METABOLIC SYNDROME; VASCULAR DYSFUNCTION;
   OBESITY; ADIPONECTIN; ACTIVATION; DECREASE
AB Background: Angiotensin II (Ang II), released by the renin-angiotensin-aldosterone system (RAAS), contributes to the modulatory role of the RAAS in adipose tissue dysfunction. Investigators have shown that inhibition of AngII improved adipose tissue function and insulin resistance in mice with metabolic syndrome. Heme Oxygenase-1 (HO-1), a potent antioxidant, has been demonstrated to improve oxidative stress and adipocyte phenotype. Molecular effects of high oxidative stress include suppression of sirtuin-1 (SIRT1), which is amenable to redox manipulations. The mechanisms involved, however, in these metabolic effects of the RAAS remain incompletely understood. Hypothesis: We hypothesize that AngII-induced oxidative stress has the potential to suppress adipocyte SIRT1 via down regulation of HO-1. This effect of AngII will, in turn, upregulate mineralocorticoid receptor (MR). The induction of HO-1 will rescue SIRT1, hence improving oxidative stress and adipocyte phenotype. Methods and Results: We examined the effect of AngII on lipid accumulation, oxidative stress, and inflammatory cytokines in mouse pre-adipocytes in the presence and absence of cobalt protoporphyrin (CoPP), HO-1 inducer, tin mesoporphyrin (SnMP), and HO-1 inhibitor. Our results show that treatment of mouse pre-adipocytes with AngII increased lipid accumulation, superoxide levels, inflammatory cytokine levels, interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF alpha), and adiponectin levels. This effect was attenuated by HO-1 induction, which was further reversed by SnMP, suggesting HO-1 mediated improvement in adipocyte phenotype. AngII-treated pre-adipocytes also showed upregulated levels of MR and suppressed SIRT1 that was rescued by HO-1. Subsequent treatment with CoPP and SIRT1 siRNA in mouse pre-adipocytes increased lipid accumulation and fatty acid synthase (FAS) levels, suggesting that beneficial effects of HO-1 are mediated via SIRT1. Conclusion: Our study demonstrates for the first time that HO-1 has the ability to restore cellular redox, rescue SIRT1, and prevent AngII-induced impaired effects on adipocytes and the systemic metabolic profile.
C1 [Lakhani, Hari Vishal; Zehra, Mishghan; Pillai, Sneha S.; Puri, Nitin; Shapiro, Joseph I.; Sodhi, Komal] Marshall Univ, Joan C Edwards Sch Med, Dept Surg Internal Med & Biomed Sci, Huntington, WV 25701 USA.
   [Abraham, Nader G.] New York Med Coll, Dept Pharmacol, Valhalla, NY 10595 USA.
C3 Marshall University; New York Medical College
RP Sodhi, K (corresponding author), Marshall Univ, Joan C Edwards Sch Med, Dept Surg Internal Med & Biomed Sci, Huntington, WV 25701 USA.
EM sodhi@marshall.edu
FU National Institutes of Health [HL109015, HL105649, HL071556];
   Brickstreet Foundation
FX This work was supported by National Institutes of Health Grants to JIS
   (HL109015, HL105649 and HL071556), and by the Brickstreet Foundation
   (J.I.S.).
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NR 50
TC 12
Z9 13
U1 0
U2 6
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD JUL 1
PY 2019
VL 20
IS 13
AR 3205
DI 10.3390/ijms20133205
PG 13
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA IL1EG
UT WOS:000477041100093
PM 31261892
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU De Oliveira, CM
   De Oliveira, C
   Scarabelot, VL
   Ströher, R
   Macedo, IC
   Souza, A
   Lopes, BC
   Caumo, W
   Torres, ILS
AF De Oliveira, Cleverson Moraes
   De Oliveira, Carla
   Scarabelot, Vanesssa Leal
   Stroher, Roberta
   Macedo, Isabel Cristina
   Souza, Andressa
   Lopes, Bettega Costa
   Caumo, Wolnei
   Silva Torres, Iraci Lucena
TI Hypercaloric diet and chronic stress desynchronizes the temporal pattern
   of rats' insulin release
SO BIOLOGICAL RHYTHM RESEARCH
LA English
DT Article
DE Circadian rhythms; metabolic disorders; high-fat foods; environmental
   factors; hormonal biomarkers
ID HIGH-FAT DIET; SUPRACHIASMATIC NUCLEUS CONTROLS; CLOCK MUTANT MICE;
   METABOLIC SYNDROME; CIRCADIAN-RHYTHMS; DIABETES-MELLITUS;
   FEEDING-BEHAVIOR; INDUCED OBESITY; ENERGY-BALANCE; BODY-WEIGHT
AB This study evaluated the effects of the association between obesity and chronic stress on the temporal pattern of serum levels of biochemical and hormonal markers. Obesity model was achieved by hypercaloric diet exposure. Wistar rats were divided into four groups: standard chow (C), hypercaloric diet (HD), stress + standard chow (S), and stress + hypercaloric diet (SHD) and analysed at three time points: ZTO, ZT12 and ZT18. Chronic stress was performed 1 h/per day, 5 days/per week, during 80 days. The presence of temporal pattern in naive animals' insulin release was accomplished. Hypercaloric diet induced obesity, increasing rats' insulin and glucose levels; while chronic stress reduced insulin levels. There were interactions between chronic stress and obesity in serum insulin and glucose levels; and between time points and obesity in insulin levels. In conclusion, long exposure to hypercaloric diet and chronic stress were able to desynchronize temporal pattern of insulin release, contributing to the pathophysiology of obesity and its complications.
C1 [De Oliveira, Cleverson Moraes; De Oliveira, Carla; Souza, Andressa; Caumo, Wolnei; Silva Torres, Iraci Lucena] Univ Fed Rio Grande do Sul, Programa Posgrad Ciencias Med, Porto Alegre, Brazil.
   [De Oliveira, Cleverson Moraes; De Oliveira, Carla; Scarabelot, Vanesssa Leal; Stroher, Roberta; Macedo, Isabel Cristina; Souza, Andressa; Lopes, Bettega Costa; Silva Torres, Iraci Lucena] Univ Fed Rio Grande do Sul, Dept Farmacol ICBS, Lab Farmacol Dor & Neuromodulacao Invest Preclin, Porto Alegre, RS, Brazil.
   [De Oliveira, Cleverson Moraes; De Oliveira, Carla; Scarabelot, Vanesssa Leal; Stroher, Roberta; Souza, Andressa; Lopes, Bettega Costa; Silva Torres, Iraci Lucena] Univ Fed Rio Grande do Sul, Hosp Clin Porto Alegre, Unidade Expt Anim, Porto Alegre, RS, Brazil.
   [De Oliveira, Cleverson Moraes; De Oliveira, Carla; Scarabelot, Vanesssa Leal; Stroher, Roberta; Souza, Andressa; Lopes, Bettega Costa; Silva Torres, Iraci Lucena] Univ Fed Rio Grande do Sul, Hosp Clin Porto Alegre, Grp Pesquisa & Posgrad, Porto Alegre, RS, Brazil.
   [Scarabelot, Vanesssa Leal] Univ Oeste Parana UNIOESTE, CCBS, Cascavel, Brazil.
   [Stroher, Roberta; Silva Torres, Iraci Lucena] Univ Fed Rio Grande do Sul, ICBS, Programa Posgrad Ciencias Biol Farmacol & Terapeu, Porto Alegre, RS, Brazil.
   [Macedo, Isabel Cristina] Univ Fed Pampa, Dept Ciencias Biol, Sao Gabriel, Brazil.
C3 Universidade Federal do Rio Grande do Sul; Universidade Federal do Rio
   Grande do Sul; Hospital de Clinicas de Porto Alegre; Universidade
   Federal do Rio Grande do Sul; Universidade Federal do Rio Grande do Sul;
   Hospital de Clinicas de Porto Alegre; Universidade Estadual do Oeste do
   Parana; Universidade Federal do Rio Grande do Sul; Universidade Federal
   do Pampa
RP De Oliveira, C; Torres, ILS (corresponding author), Univ Fed Rio Grande do Sul, Programa Posgrad Ciencias Med, Porto Alegre, Brazil.; De Oliveira, C; Torres, ILS (corresponding author), Univ Fed Rio Grande do Sul, Dept Farmacol ICBS, Lab Farmacol Dor & Neuromodulacao Invest Preclin, Porto Alegre, RS, Brazil.; De Oliveira, C; Torres, ILS (corresponding author), Univ Fed Rio Grande do Sul, Hosp Clin Porto Alegre, Unidade Expt Anim, Porto Alegre, RS, Brazil.; De Oliveira, C; Torres, ILS (corresponding author), Univ Fed Rio Grande do Sul, Hosp Clin Porto Alegre, Grp Pesquisa & Posgrad, Porto Alegre, RS, Brazil.; Torres, ILS (corresponding author), Univ Fed Rio Grande do Sul, ICBS, Programa Posgrad Ciencias Biol Farmacol & Terapeu, Porto Alegre, RS, Brazil.
EM carla.doliveira@yahoo.com.br; iltorres@hcpa.edu.br
RI IC, Macedo/B-3151-2015; Costa Lopes, Bettega/AAG-5974-2020; Oliveira,
   Carla/F-6351-2015; caumo, wolnei/Q-8728-2016; de Souza,
   Andressa/Q-2446-2016; Oliveira, Cleverson/HPE-1938-2023; Torres, Iraci
   LS/G-6693-2012
OI Caumo, Wolnei/0000-0002-5083-4658; Costa Lopes,
   Bettega/0000-0002-8090-0273; Oliveira, Cleverson/0000-0003-0861-6136;
   Torres, Iraci LS/0000-0002-3081-115X
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NR 60
TC 0
Z9 0
U1 0
U2 0
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0929-1016
EI 1744-4179
J9 BIOL RHYTHM RES
JI Biol. Rhythm Res.
PY 2018
VL 49
IS 4
BP 643
EP 653
DI 10.1080/09291016.2017.1395528
PG 11
WC Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics; Physiology
GA GE0VG
UT WOS:000430934200012
DA 2025-06-11
ER

PT J
AU Rangel-Zuñiga, OA
   Haro, C
   Perez-Martinez, P
   Delgado-Lista, J
   Marin, C
   Quintana-Navarro, GM
   Tinahones, FJ
   Malagón, MM
   Lopez-Segura, F
   Lopez-Miranda, J
   Perez-Jimenez, F
   Camargo, A
AF Rangel-Zuniga, Oriol A.
   Haro, Carmen
   Perez-Martinez, Pablo
   Delgado-Lista, Javier
   Marin, Carmen
   Quintana-Navarro, Gracia M.
   Tinahones, Francisco J.
   Malagon, Maria M.
   Lopez-Segura, Fernando
   Lopez-Miranda, Jose
   Perez-Jimenez, Francisco
   Camargo, Antonio
TI Effect of frying oils on the postprandial endoplasmic reticulum stress
   in obese people
SO MOLECULAR NUTRITION & FOOD RESEARCH
LA English
DT Article
DE ER stress; Frying oil; Mononuclear cells; Phenolic compounds;
   Postprandial state
ID METABOLIC SYNDROME; OLIVE; ANTIOXIDANTS; CELLS
AB The addition of antioxidants to frying oil reduces postprandial oxidative stress and the inflammatory response. ER stress may trigger both inflammation and oxidative stress processes. We aimed to determine the biological effects of the intake of four models of frying oils on postprandial ER stress in peripheral blood mononuclear cells. Twenty obese people received four breakfasts following a randomized crossover design, consisting of muffins made with different oils (virgin olive oil (VOO), sunflower oil (SFO), and a mixture of seed oils (SFO/canola oil) with either dimethylpolysiloxane (SOD) or natural antioxidants from olives (SOP) added), which were previously subjected to 20 heating cycles. ER stress was assessed by measuring the mRNA levels of sXBP1, BiP, CRT, and CNX in peripheral blood mononuclear cells. Our study showed that the intake of the muffins made with SFO induced the postprandial increase of the mRNA levels of the ER stress-sensor sXBP1, and the ER stress related chaperones BiP and CRT (all p-values <0.05). The harmful effects associated with the use of SFO as frying oil, in terms of inflammatory response and postprandial oxidative stress, may be partially mediated by the induction of postprandial ER stress.
C1 [Rangel-Zuniga, Oriol A.; Haro, Carmen; Perez-Martinez, Pablo; Delgado-Lista, Javier; Marin, Carmen; Quintana-Navarro, Gracia M.; Lopez-Segura, Fernando; Lopez-Miranda, Jose; Perez-Jimenez, Francisco; Camargo, Antonio] Univ Cordoba, Lipids & Atherosclerosis Unit, IMIBIC, Reina Sofia Univ Hosp, E-14004 Cordoba, Spain.
   [Rangel-Zuniga, Oriol A.; Haro, Carmen; Perez-Martinez, Pablo; Delgado-Lista, Javier; Marin, Carmen; Quintana-Navarro, Gracia M.; Tinahones, Francisco J.; Malagon, Maria M.; Lopez-Segura, Fernando; Lopez-Miranda, Jose; Perez-Jimenez, Francisco; Camargo, Antonio] Inst Salud Carlos III, CIBER Fisiopatol Obes & Nutr CIBEROBN, Cordoba, Spain.
   [Tinahones, Francisco J.] Hosp Virgen Victoria, Endocrinol & Nutr Serv, Malaga, Spain.
   [Malagon, Maria M.] Univ Cordoba, Dept Cell Biol Physiol & Immunol, IMIBIC, Reina Sofia Univ Hosp, E-14004 Cordoba, Spain.
C3 Universidad de Cordoba; CIBER - Centro de Investigacion Biomedica en
   Red; CIBEROBN; Instituto de Salud Carlos III; Universidad de Cordoba
RP Camargo, A (corresponding author), Univ Cordoba, Lipids & Atherosclerosis Unit, IMIBIC, Reina Sofia Univ Hosp, Ave Menendez Pidal S-N, E-14004 Cordoba, Spain.
EM b92cagaa@uco.es
RI Lopez-Miranda, Jose/Y-8306-2019; Marin Hinojosa, Carmen/AFO-1294-2022;
   Tinahones, Francisco/AAB-2882-2020; Delgado-Lista, Javier/KAM-7412-2024;
   Jimenez, Francisco/AAJ-9559-2021; MALAGON, MARIA M/L-5386-2014; Camargo
   Garcia, Antonio/G-9720-2015; Perez Martinez, Pablo/AEL-6176-2022; HARO,
   CARMEN/P-3104-2016
OI MALAGON, MARIA M/0000-0002-2419-2727; Rangel-Zuniga, Oriol
   Alberto/0000-0003-3495-5705; QUINTANA-NAVARRO, GRACIA
   MARIA/0000-0003-4413-4062; Lopez-Miranda, Jose/0000-0002-8844-0718;
   Camargo Garcia, Antonio/0000-0002-0415-4184; Perez Jimenez,
   Francisco/0000-0001-9808-1280; Perez Martinez,
   Pablo/0000-0001-7716-8117; Delgado Lista, Francisco
   Javier/0000-0002-2982-2716; Tinahones, Francisco J/0000-0001-6871-4403;
   HARO, CARMEN/0000-0002-1355-8359; Perez-Jimenez,
   Francisco/0000-0001-7499-7681
FU Spanish Ministry of Science and Innovation [AGL 2004-07907, AGL
   2006-01979, AGL 2009-12270, SAF07-62005, FIS PI10/01041, PI10/02412];
   Consejeria de Economia, Innovacion y Ciencia, Proyectos de Investigacion
   de Excelencia, Junta de Andalucia [P06-CTS-01425, CTS5015, AGR922];
   Consejeria de Salud, Junta de Andalucia [06/128, 07/43, PI0193/09,
   06/129, 06/127, PI-0252/09, PI-0058/10]; Fondo Europeo de Desarrollo
   Regional (FEDER)
FX The CIBEROBN is an initiative of the Instituto de Salud Carlos III,
   Madrid, Spain. This study was supported in part by research grants from
   the Spanish Ministry of Science and Innovation (AGL 2004-07907, AGL
   2006-01979, and AGL 2009-12270 to J. L.-M., SAF07-62005 to F. P.-J., and
   FIS PI10/01041 to P. P.-M., PI10/02412 to F. P.-J.); Consejeria de
   Economia, Innovacion y Ciencia, Proyectos de Investigacion de
   Excelencia, Junta de Andalucia (P06-CTS-01425 to J. L.-M., CTS5015 and
   AGR922 to F. P.-J.); Consejeria de Salud, Junta de Andalucia (06/128,
   07/43, and PI0193/09 to J. L.-M, 06/129 to F. P.-J., 06/127 to C. M.-H.,
   PI-0252/09 to J. D.-L., and PI-0058/10 to P. P.-M.); Fondo Europeo de
   Desarrollo Regional (FEDER). We would also like to thank Jose Linares
   from DEOLEO, S.A., for providing the SFO used in this research, and the
   Catering School of Bodegas Campos in Cordoba, Spain, for cooperating in
   the standardized heating process of the four oils used in the present
   study.
CR Ansorena D, 2010, J FOOD SCI, V75, pH62, DOI 10.1111/j.1750-3841.2009.01472.x
   Biden TJ, 2014, TRENDS ENDOCRIN MET, V25, P389, DOI 10.1016/j.tem.2014.02.003
   Burczynski ME, 2006, PHARMACOGENOMICS, V7, P187, DOI 10.2217/14622416.7.2.187
   Camargo A, 2013, MOL NUTR FOOD RES, V57, P2166, DOI 10.1002/mnfr.201300036
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   Marchetti P, 2007, DIABETOLOGIA, V50, P2486, DOI 10.1007/s00125-007-0816-8
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   Perez-Herrera A, 2012, MOL NUTR FOOD RES, V56, P510, DOI 10.1002/mnfr.201100533
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NR 21
TC 10
Z9 11
U1 0
U2 10
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1613-4125
EI 1613-4133
J9 MOL NUTR FOOD RES
JI Mol. Nutr. Food Res.
PD NOV
PY 2014
VL 58
IS 11
BP 2239
EP 2242
DI 10.1002/mnfr.201400401
PG 4
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA AT8XK
UT WOS:000345212200015
PM 25164487
DA 2025-06-11
ER

PT J
AU Perez-Cornago, A
   Sanchez-Villegas, A
   Bes-Rastrollo, M
   Gea, A
   Molero, P
   Lahortiga-Ramos, F
   Martínez-González, MA
AF Perez-Cornago, Aurora
   Sanchez-Villegas, Almudena
   Bes-Rastrollo, Maira
   Gea, Alfredo
   Molero, Patricio
   Lahortiga-Ramos, Francisca
   Angel Martinez-Gonzalez, Miguel
TI Intake of High-Fat Yogurt, but Not of Low-Fat Yogurt or Prebiotics, Is
   Related to Lower Risk of Depression in Women of the SUN Cohort Study
SO JOURNAL OF NUTRITION
LA English
DT Article
DE depression; yogurt; prebiotics; fiber; probiotics
ID METABOLIC SYNDROME; SEGUIMIENTO-UNIVERSIDAD; DAIRY-PRODUCTS; GUT
   MICROBIOTA; BRAIN AXIS; PROBIOTICS; CONSUMPTION; HEALTH; DIET;
   ASSOCIATION
AB Background: Yogurt and prebiotic consumption has been linked to better health. However, to our knowledge, no longitudinal study has assessed the association of yogurt and prebiotic consumption with depression risk.
   Objective: We longitudinally evaluated the association of yogurt and prebiotic consumption with depression risk in a Mediterranean cohort.
   Methods: The SUN (Seguimiento Universidad de Navarra) Project is a dynamic, prospective cohort of Spanish university graduates. A total of 14,539 men and women (mean age: 37 y) initially free of depression were assessed during a median follow-up period of 9.3 y. Validated food-frequency questionnaires at baseline and after a 10-y follow-up were used to assess prebiotic (fructans and galacto-oligosaccharide) intake and yogurt consumption (<0.5, >= 0.5 to <3, >= 3 to <7, and >= 7 servings/wk). Participants were classified as incident cases of depression when they reported a new clinical diagnosis of depression by a physician (previously validated). Multivariable Cox proportional hazards models were used to calculate HRs and 95% Cls.
   Results: We identified 727 incident cases of depression during follow-up. Whole-fat yogurt intake was associated with reduced depression risk: HR for the highest [>= 7 servings/wk (1 serving = 125 g)] compared with the lowest (<0.5 servings/wk) consumption: 0.78 (95% CI: 0.63, 0.98; P-trend = 0.020). When stratified by sex, this association was significant only in women (HR: 0.66; 95% CI: 0.50, 0.87; P-trend = 0.004). Low-fat yogurt consumption was associated with a higher incidence of depression (HR: 1.32; 95% CI: 1.06, 1.65; P-trend = 0.001), although this association lost significance after the exclusion of early incident cases, suggesting possible reverse causation bias. Prebiotic consumption was not significantly associated with depression risk.
   Conclusions: Our study suggests that high consumption of whole-fat yogurt was related to a lower risk of depression in women of the SUN cohort. No association was observed for prebiotics. Further studies are needed to clarify why the yogurt-depression association may differ by fat content of the yogurt.
C1 [Perez-Cornago, Aurora; Bes-Rastrollo, Maira; Gea, Alfredo; Angel Martinez-Gonzalez, Miguel] Univ Navarra, Dept Prevent Med & Publ Hlth, Pamplona, Spain.
   [Perez-Cornago, Aurora] Univ Oxford, Nuffield Dept Populat Hlth, Canc Epidemiol Unit, Oxford, England.
   [Sanchez-Villegas, Almudena] Univ Las Palmas Gran Canaria, Res Inst Biomed & Hlth Sci, Nutr Res Grp, Las Palmas Gran Canaria, Spain.
   [Sanchez-Villegas, Almudena; Bes-Rastrollo, Maira; Gea, Alfredo; Angel Martinez-Gonzalez, Miguel] Inst Hlth Carlos III, Biomed Res Ctr Network Obes & Nutr CIBERobn Physi, Madrid, Spain.
   [Bes-Rastrollo, Maira; Gea, Alfredo; Molero, Patricio; Lahortiga-Ramos, Francisca; Angel Martinez-Gonzalez, Miguel] Navarra Inst Hlth Res IdiSNA Pamplona, Pamplona, Spain.
   [Molero, Patricio; Lahortiga-Ramos, Francisca] Univ Navarra Clin, Dept Psychiat & Med Psychol, Pamplona, Spain.
C3 University of Navarra; University of Oxford; Universidad de Las Palmas
   de Gran Canaria; CIBER - Centro de Investigacion Biomedica en Red;
   CIBEROBN; University of Navarra
RP Martínez-González, MA (corresponding author), Univ Navarra, Dept Prevent Med & Publ Hlth, Pamplona, Spain.; Martínez-González, MA (corresponding author), Inst Hlth Carlos III, Biomed Res Ctr Network Obes & Nutr CIBERobn Physi, Madrid, Spain.; Martínez-González, MA (corresponding author), Navarra Inst Hlth Res IdiSNA Pamplona, Pamplona, Spain.
EM mamartinez@unav.es
RI Sanchez-Villegas, Almudena/T-6733-2019; Martínez-González,
   Marina/R-6165-2016; Abad-Gurumeta, Alfredo/M-2337-2019;
   Martinez-Gonzalez, Miguel/AAE-7669-2019; Perez-Cornago,
   Aurora/C-1097-2016; BES-RASTROLLO, MAIRA/A-1329-2009; Molero,
   Patricio/K-8834-2013; Lahortiga-Ramos, Francisca/H-9363-2017
OI Perez-Cornago, Aurora/0000-0002-5652-356X; BES-RASTROLLO,
   MAIRA/0000-0002-9139-4206; Martinez-Gonzalez, Miguel
   A./0000-0002-3917-9808; Molero, Patricio/0000-0002-9287-9635;
   Lahortiga-Ramos, Francisca/0000-0001-7624-6902; Gea,
   Alfredo/0000-0002-2229-4690; Sanchez Villegas,
   Almudena/0000-0001-7733-9238
FU Spanish Government-Instituto de Salud Carlos III [PI01/0619, PI030678,
   PI040233, PI042241, PI050976, PI070240, PI070312, PI081943, PI080819,
   PI1002658, PI1002293, RD06/0045, 2010/087, G03/140]; Navarra Regional
   Government [36/2001, 43/2002, 41/2005, 36/2008, 45/2011]; Formacion de
   Profesorado Universitario FPU fellowship of the Ministerio de Educacion,
   Cultura y Deporte, Spanish Government
FX The SUN Project has received funding from the Spanish
   Government-Instituto de Salud Carlos III (grants PI01/0619, PI030678,
   PI040233, PI042241, PI050976, PI070240, PI070312, PI081943, PI080819,
   PI1002658, PI1002293, RD06/0045, 2010/087, and G03/140), the Navarra
   Regional Government (36/2001, 43/2002, 41/2005, 36/2008, and 45/2011),
   and the University of Navarra AG is supported by an Formacion de
   Profesorado Universitario FPU fellowship of the Ministerio de Educacion,
   Cultura y Deporte, Spanish Government.
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NR 56
TC 29
Z9 33
U1 0
U2 46
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0022-3166
EI 1541-6100
J9 J NUTR
JI J. Nutr.
PD SEP
PY 2016
VL 146
IS 9
BP 1731
EP 1739
DI 10.3945/jn.116.233858
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA DU7VN
UT WOS:000382422800015
PM 27466606
OA Green Submitted, Bronze
DA 2025-06-11
ER

PT J
AU Igna, CV
   Julkunen, J
   Vanhanen, H
   Keskivaara, P
   Verkasalo, M
AF Igna, Cornel Victor
   Julkunen, Juhani
   Vanhanen, Hannu
   Keskivaara, Pertti
   Verkasalo, Markku
TI Depressive Symptoms and Serum Lipid Fractions in Middle-Aged Men:
   Physiologic and Health Behavior Links
SO PSYCHOSOMATIC MEDICINE
LA English
DT Article
DE depression; cholesterol; HDL; LDL; cardiovascular diseases; health
   behavior
ID CORONARY-HEART-DISEASE; LIFE-STYLE FACTORS; DENSITY-LIPOPROTEIN
   CHOLESTEROL; RISK-FACTOR; CARDIOVASCULAR-DISEASE; MARITAL TRANSITIONS;
   SMOKING-BEHAVIOR; SUICIDE RISK; FOLLOW-UP; OVERWEIGHT
AB Objective: To investigate alternative hypothetical models that could clarify the relationship between depressive symptoms and serum cholesterol fractions, i.e., high-density lipoprotein (HDL) and low-density lipoprotein (LDL). It was hypothesized that the impact of the depressive symptoms on cholesterol fractions is mediated through health behavior and body mass index, and at the same time there would be a direct link from depression to cholesterol. Methods: The study sample consisted of 893 middle-age men who participated in a trial aimed at preventing the metabolic syndrome, Type 2 diabetes and cardiovascular diseases. Serum cholesterol was measured by the enzymatic method. Participants completed self-report questionnaires assessing health behavior and depressive symptoms. Results: Depressive symptoms consistently correlated statistically significantly with adverse lifestyle factors and, as hypothesized, positively with HDL. Path analyses supported the parallel existence of two main pathways: from depression through adverse health behavior to unfavorable cholesterol fraction balance, and a direct physiological link indicative of beneficial effect of depression on cholesterol levels. Conclusions: It is concluded that, among a sample of men, depressive symptoms are linked to cholesterol fractions through two different pathways. An adverse relationship of depression with serum lipids HDL-LDL balance is partly mediated through harmful health behaviors. At the same time, the results indicate a direct, physiological link between depressive symptoms and cholesterol that has a beneficial influence on the HDL-LDL balance.
C1 [Igna, Cornel Victor; Julkunen, Juhani; Keskivaara, Pertti; Verkasalo, Markku] Univ Helsinki, Dept Psychol, SF-00100 Helsinki, Finland.
   [Vanhanen, Hannu] Finnish Heart Assoc, Helsinki, Finland.
C3 University of Helsinki
RP Julkunen, J (corresponding author), Univ Helsinki, Dept Psychol, Fabianinkatu 28, SF-00100 Helsinki, Finland.
EM juhani.julkunen@helsinki.fi
OI Verkasalo, Markku/0000-0002-4356-9649
FU Finnish Slot Machine Corporation
FX The main study was funded by the Finnish Slot Machine Corporation.
   Received for publication December 10, 2007; revision received June 12,
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NR 61
TC 20
Z9 26
U1 0
U2 13
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0033-3174
EI 1534-7796
J9 PSYCHOSOM MED
JI Psychosom. Med.
PD NOV-DEC
PY 2008
VL 70
IS 9
BP 960
EP 966
DI 10.1097/PSY.0b013e318189a942
PG 7
WC Psychiatry; Psychology; Psychology, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry; Psychology
GA 375RE
UT WOS:000261130200002
PM 18981271
DA 2025-06-11
ER

PT J
AU Iob, E
   Steptoe, A
AF Iob, Eleonora
   Steptoe, Andrew
TI Cardiovascular Disease and Hair Cortisol: a Novel Biomarker of Chronic
   Stress
SO CURRENT CARDIOLOGY REPORTS
LA English
DT Review
DE Chronic stress; Hair cortisol; Cardiovascular disease; Cardiometabolic
   markers
ID CORONARY-HEART-DISEASE; ADRENAL-AXIS DYSREGULATION; QUALITY-OF-LIFE;
   RISK-FACTORS; SALIVARY CORTISOL; MYOCARDIAL-INFARCTION;
   DIABETES-MELLITUS; URINARY CORTISOL; BLOOD-PRESSURE; ALL-CAUSE
AB Purpose of Review This review focuses on the concentration of cortisol in human hair as a biomarker of chronic stress in cardiovascular disease (CVD). We outline the cardiovascular consequences of cortisol excess and provide a comprehensive overview of recent studies investigating the relationship of hair cortisol with CVD. In addition, clinical implications and limitations of the evidence are discussed, together with directions for future research. Recent Findings Hair cortisol may be a reliable biomarker of chronic stress since it provides quantification of total cortisol secreted into hair over several weeks. A growing body of evidence suggests that elevated hair cortisol levels are associated with both the incidence of CVD and poorer recovery and treatment outcomes. Moreover, increased hair cortisol concentration has been linked with established cardiometabolic risk factors for CVD including high blood pressure, diabetes, and adiposity. Hair cortisol is a promising biomarker of chronic cortisol excess which may contribute to both the pathogenesis and prognosis of CVD. However, the current evidence relies on small-scale cross-sectional studies. Further research adopting longitudinal designs across larger samples of CVD patients and healthy participants is required to inform the development of novel evidence-based interventions.
C1 [Iob, Eleonora; Steptoe, Andrew] UCL, Dept Behav Sci & Hlth, Gower St, London WC1E 6BT, England.
C3 University of London; University College London
RP Iob, E (corresponding author), UCL, Dept Behav Sci & Hlth, Gower St, London WC1E 6BT, England.
EM eleonora.iob.17@ucl.ac.uk; a.steptoe@ucl.ac.uk
RI Iob, Eleonora/AAF-1224-2021; Steptoe, Andrew/Y-2440-2019
OI Iob, Eleonora/0000-0003-3617-0266
FU ESRC-BBSRC Soc-B Centre for Doctoral Training [ES/P000347/1]; ESRC
   [1907703] Funding Source: UKRI
FX E. Iob is supported by the ESRC-BBSRC Soc-B Centre for Doctoral Training
   (ES/P000347/1).
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NR 112
TC 124
Z9 143
U1 2
U2 60
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1523-3782
EI 1534-3170
J9 CURR CARDIOL REP
JI Curr. Cardiol. Rep.
PD OCT
PY 2019
VL 21
IS 10
AR 116
DI 10.1007/s11886-019-1208-7
PG 11
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Cardiovascular System & Cardiology
GA IU8RQ
UT WOS:000483849600005
PM 31471749
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Barbosa-Leiker, C
   Roper, V
   McPherson, S
   Lei, M
   Wright, B
   Hoekstra, T
   Kostick, M
AF Barbosa-Leiker, Celestina
   Roper, Virginia
   McPherson, Sterling
   Lei, Ming
   Wright, Bruce
   Hoekstra, Trynke
   Kostick, Marylynne
TI Cross-sectional and Longitudinal Relationships between Perceived Stress
   and C-reactive Protein in Men and Women
SO STRESS AND HEALTH
LA English
DT Article
DE C-reactive protein; inflammation; perceived stress
ID CARDIOVASCULAR RISK-FACTORS; CYTOKINE PRODUCTION; METABOLIC SYNDROME;
   SEX-DIFFERENCES; OLDER-ADULTS; INFLAMMATION; DISEASE; SENSITIVITY;
   EVENTS; HEALTH
AB To date, an examination of the longitudinal relationship between perceived stress and C-reactive protein (CRP) is limited. We explored the relationship between perceived stress and CRP concurrently and across 2 and 4 years in 383 men and women. Multiple linear regressions examined the cross-sectional and longitudinal relationships between baseline stress and counter-stress scores with CRP at baseline, 2 years after baseline and 4 years after baseline, while controlling for covariates (age, smoking status, anti-inflammatory use, oral contraceptive use, physical activity, menopausal status, years since onset of menopause, post-menopausal hormone use and body mass index). Results indicate that stress and counter-stress were not related to CRP in either men or women at study baseline or 2 years later. Across a 4-year time frame, higher stress values were related to higher CRP values in women, but not men. Counter-stress was not related to CRP values in men or women across the 4 years. This study highlights the importance of examining the cross-sectional and longitudinal relationship between perceived stress and inflammation separately in men and women. Copyright (C) 2013 John Wiley & Sons, Ltd.
C1 [Barbosa-Leiker, Celestina; McPherson, Sterling] Washington State Univ, Coll Nursing, Spokane, WA 99210 USA.
   [Barbosa-Leiker, Celestina; McPherson, Sterling] Washington State Univ, Dept Psychol, Pullman, WA 99164 USA.
   [Roper, Virginia] SUNY Upstate Med Univ, Syracuse, NY 13210 USA.
   [Lei, Ming] Washington State Univ, Edward R Murrow Coll Commun, Pullman, WA 99164 USA.
   [Wright, Bruce] Washington State Univ, Pullman, WA 99164 USA.
   [Hoekstra, Trynke] Vrije Univ Amsterdam, Dept Hlth Sci, Amsterdam, Netherlands.
   [Hoekstra, Trynke] Vrije Univ Amsterdam, EMGO Inst Hlth & Care Res, Amsterdam, Netherlands.
   [Hoekstra, Trynke] Vrije Univ Amsterdam, Med Ctr, Dept Epidemiol & Biostat, Amsterdam, Netherlands.
   [Hoekstra, Trynke] Vrije Univ Amsterdam, Med Ctr, EMGO Inst Hlth & Care Res, Amsterdam, Netherlands.
   [Kostick, Marylynne] Univ Alaska Anchorage, Dept Hlth Sci, Anchorage, AK USA.
C3 Washington State University; Washington State University; State
   University of New York (SUNY) System; State University of New York
   (SUNY) Upstate Medical Center; Washington State University; Washington
   State University; Vrije Universiteit Amsterdam; Vrije Universiteit
   Amsterdam; Vrije Universiteit Amsterdam; Vrije Universiteit Amsterdam;
   University of Alaska System; University of Alaska Anchorage
RP Barbosa-Leiker, C (corresponding author), Washington State Univ, Coll Nursing, POB 1495, Spokane, WA 99210 USA.
EM celestina@wsu.edu
RI Wright, Bruce/R-6107-2019; Hoekstra, Trynke/AAG-5901-2020
OI Hoekstra, Trynke/0000-0002-0535-0056
FU E. L. Wiegand Foundation; Washington State University; Providence
   Medical Research Center; Sacred Heart Medical Center
FX The authors would like to thank C. Harold Mielke, MD, J. Paul Shields,
   MD, Dennis Dyck, PhD, and all other members of the Spokane Heart Study
   Steering Committee. Funding sources for the Spokane Heart Study have
   included the E. L. Wiegand Foundation, Washington State University,
   Providence Medical Research Center and Sacred Heart Medical Center.
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NR 50
TC 10
Z9 11
U1 0
U2 19
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1532-3005
EI 1532-2998
J9 STRESS HEALTH
JI Stress Health
PD APR
PY 2014
VL 30
IS 2
BP 158
EP 165
DI 10.1002/smi.2507
PG 8
WC Psychology, Applied; Psychiatry; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA AJ2JO
UT WOS:000337482100009
PM 23818431
DA 2025-06-11
ER

PT J
AU Dehghan, P
   Pourmoradian, S
   Mahdavi, AM
   Sarmadi, B
   Mehralizadeh, S
AF Dehghan, Parvin
   Pourmoradian, Samira
   Mahdavi, Aida Malek
   Sarmadi, Bahareh
   Mehralizadeh, Sajjad
TI RELATIONSHIP BETWEEN PERCEIVED STRESS AND DIETARY INTAKES IN TYPE 2
   DIABETIC PATIENTS
SO CURRENT TOPICS IN NUTRACEUTICAL RESEARCH
LA English
DT Article
DE Diet; Micronutrients; Perceived stress; Type 2 diabetes.
ID FOOD-INTAKE; EATING BEHAVIOR; HEALTH BEHAVIORS; METABOLIC SYNDROME;
   COLLEGE-STUDENTS; CONTROLLED-TRIAL; DOUBLE-BLIND; ADULT MALES; MOOD;
   WOMEN
AB As the major aspect of lifestyle, dietary patterns are concerned with health issues in all conditions including stress. Studies on the association between stress and food choices have resulted conflicting outcomes. This cross-sectional study was conducted on a sample of type 2 diabetic patients (n = 200) who met the inclusion criteria. A 14-item questionnaire was used to measure the perceived stress. Food recall was recorded by a trained dietitian for 24 hours over 2 regular days and 1 holiday. Liner regression results indicated that negative perceived stress had association with carbohydrate intake (B=0.246, P=0.04) which for the Positive perceived stress it was directly associated with mean protein (B=0.14, P=0.04) and fiber intakes (B=0.46, P=0.001). Based on the finding, there was a relationship between micronutrient intake and positive perceived stress. Positive perceived stress leads to healthy food choices while negative perceived stress leads to the unhealthy dietary patterns. A diet with adequate vitamin B complex, vitamin E and antioxidant minerals (selenium, zinc, copper, magnesium) may have positive effects in coping with stress and help positive interpretation of stressful events.
C1 [Dehghan, Parvin] Tabriz Univ Med Sci, Fac Nutr, Nutr Res Ctr, Student Res Comm, Tabriz, Iran.
   [Pourmoradian, Samira] Shahid Beheshti Univ Med Sci & Hlth Serv, Fac Nutr & Food Technol, Dept Community Nutr, Tehran, Iran.
   [Mahdavi, Aida Malek] Tabriz Univ Med Sci, Connect Tissue Dis Res Ctr, Tabriz, Iran.
   [Sarmadi, Bahareh] Dept Nutr & Dietet, Putrajaya, Selangor, Malaysia.
   [Mehralizadeh, Sajjad] Tabriz Univ Med Sci, Tabriz, Iran.
C3 Tabriz University of Medical Science; Shahid Beheshti University Medical
   Sciences; Tabriz University of Medical Science; Tabriz University of
   Medical Science
RP Pourmoradian, S (corresponding author), Shahid Beheshti Univ Med Sci & Hlth Serv, Fac Nutr & Food Technol, Dept Community Nutr, Tehran, Iran.
EM samira.pourmoradian@gmail.com
RI pourmoradian, samira/ABC-8141-2021; Mahdavi, Aida/N-3109-2017; Sarmadi,
   Bahareh/G-1773-2017; Dehghan, Parvin/G-3885-2015
OI Dehghan, Parvin/0000-0001-8929-3302
FU Nutrition Research center; Tabriz University of Medical Sciences
FX The authors are grateful for the financial support of the Nutrition
   Research center, Tabriz University of Medical Sciences. The authors also
   are deeply indebted to all the patients who participated in this study.
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NR 62
TC 2
Z9 2
U1 1
U2 9
PU NEW CENTURY HEALTH PUBLISHERS, LLC
PI COPPELL
PA PO BOX 175, COPPELL, TX 75019 USA
SN 1540-7535
J9 CURR TOP NUTRACEUT R
JI Curr. Top. Nutraceutical Res.
PD AUG
PY 2016
VL 14
IS 3
BP 199
EP 205
PG 7
WC Nutrition & Dietetics; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nutrition & Dietetics; Pharmacology & Pharmacy
GA DY2SS
UT WOS:000384942900003
DA 2025-06-11
ER

PT J
AU Kühnel, A
   Hagenberg, J
   Knauer-Arloth, J
   Ködel, M
   Czisch, M
   Sämann, PG
   Binder, EB
   Kroemer, NB
AF Kuehnel, Anne
   Hagenberg, Jonas
   Knauer-Arloth, Janine
   Koedel, Maik
   Czisch, Michael
   Saemann, Philipp G.
   Binder, Elisabeth B.
   Kroemer, Nils B.
CA BeCOME Working Grp
TI Stress-induced brain responses are associated with BMI in women
SO COMMUNICATIONS BIOLOGY
LA English
DT Article
ID ACUTE PSYCHOSOCIAL STRESS; BODY-MASS INDEX; SEX-DIFFERENCES; FUNCTIONAL
   CONNECTIVITY; GENDER-DIFFERENCES; METABOLIC-SYNDROME; LIMBIC SYSTEM;
   HPA-AXIS; OBESITY; CORTISOL
AB Overweight and obesity are associated with altered stress reactivity and increased inflammation. However, it is not known whether stress-induced changes in brain function scale with BMI and if such associations are driven by peripheral cytokines. Here, we investigate multimodal stress responses in a large transdiagnostic sample using predictive modeling based on spatio-temporal profiles of stress-induced changes in activation and functional connectivity. BMI is associated with increased brain responses as well as greater negative affect after stress and individual response profiles are associated with BMI in females (p(perm)<0.001), but not males. Although stress-induced changes reflecting BMI are associated with baseline cortisol, there is no robust association with peripheral cytokines. To conclude, alterations in body weight and energy metabolism might scale acute brain responses to stress more strongly in females compared to males, echoing observational studies. Our findings highlight sex-dependent associations of stress with differences in endocrine markers, largely independent of peripheral inflammation.
   In humans, brain responses to stress are associated with their body mass index, driven mostly by females. Predictive modeling showed that this link was better explained by changes in endocrine instead of immune systems.
C1 [Kuehnel, Anne; Kroemer, Nils B.] Univ Bonn, Sect Med Psychol, Dept Psychiat & Psychotherapy, Fac Med, Bonn, Germany.
   [Kuehnel, Anne; Hagenberg, Jonas; Knauer-Arloth, Janine; Koedel, Maik; Binder, Elisabeth B.] Max Planck Inst Psychiat, Dept Translat Res Psychiat, Munich, Germany.
   [Kuehnel, Anne; Hagenberg, Jonas] Int Max Planck Res Sch Translat Psychiat IMPRS TP, Munich, Germany.
   [Hagenberg, Jonas; Knauer-Arloth, Janine] Helmholtz Zentrum Munich, Inst Comp Biol, Neuherberg, Germany.
   [Czisch, Michael] Max Planck Inst Psychiat, Munich, Germany.
   [Binder, Elisabeth B.; Kroemer, Nils B.] German Ctr Mental Hlth, Tubingen, Germany.
   [Kroemer, Nils B.] Univ Tubingen, Dept Psychiat & Psychotherapy, Tubingen Ctr Mental Hlth TuCMH, Tubingen, Germany.
C3 University of Bonn; Max Planck Society; Helmholtz Association;
   Helmholtz-Center Munich - German Research Center for Environmental
   Health; Max Planck Society; Eberhard Karls University of Tubingen
RP Kühnel, A (corresponding author), Univ Bonn, Sect Med Psychol, Dept Psychiat & Psychotherapy, Fac Med, Bonn, Germany.; Kühnel, A; Binder, EB (corresponding author), Max Planck Inst Psychiat, Dept Translat Res Psychiat, Munich, Germany.; Kühnel, A (corresponding author), Int Max Planck Res Sch Translat Psychiat IMPRS TP, Munich, Germany.; Binder, EB (corresponding author), German Ctr Mental Hlth, Tubingen, Germany.
EM akuehnel@uni-bonn.de; binder@psych.mpg.de
RI Kroemer, Nils/H-8309-2019; Kuehnel, Anne/NBX-3544-2025
OI Kuhnel, Anne/0000-0003-3066-3801; Knauer-Arloth,
   Janine/0000-0003-3825-4279; Hagenberg, Jonas/0000-0002-1849-1106
FU Deutsche Forschungsgemeinschaft (DFG) [KR 4555/7-1, KR 4555/9-1, IRTG
   2804]; Brain Behaviour Research Foundation (NARSAD Young Investigator
   Grant) [28063]
FX We thank Anna Hetzel and Ines Eidner for their help with data
   acquisition, Manfred Uhr and the team of the Max Planck Institute of
   Psychiatry Biobank for sample processing. N.B.K. received support from
   the Deutsche Forschungsgemeinschaft (DFG) grants KR 4555/7-1, KR
   4555/9-1, and IRTG 2804. V.I.S. has received income from consultations
   and advisory services for Roche. J.K.-A. was supported by the Brain
   Behaviour Research Foundation (NARSAD Young Investigator Grant, #28063).
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NR 128
TC 4
Z9 4
U1 2
U2 9
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
EI 2399-3642
J9 COMMUN BIOL
JI Commun. Biol.
PD OCT 11
PY 2023
VL 6
IS 1
AR 1031
DI 10.1038/s42003-023-05396-8
PG 15
WC Biology; Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics; Science & Technology - Other
   Topics
GA AB2O6
UT WOS:001115932000001
PM 37821711
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Marcovecchio, ML
   Chiarelli, F
AF Marcovecchio, M. Loredana
   Chiarelli, Francesco
TI ENDOCRINOLOGY The Effects of Acute and Chronic Stress on Diabetes
   Control
SO SCIENCE SIGNALING
LA English
DT Article
ID RANDOMIZED CONTROLLED-TRIALS; IMPROVE GLYCEMIC CONTROL; PSYCHOLOGICAL
   INTERVENTIONS; METAANALYSIS
AB Stress is an important contributor to pathological conditions in humans. Hormonal changes that occur during acute and chronic stress situations can affect glucose homeostasis in both healthy people and in those with diabetes. Several studies have reported a negative effect of acute stress on maintenance of blood glucose concentrations in patients with type 1 and type 2 diabetes. The effect of stress on glycemic control in people with diabetes may be related to a direct effect of stress hormones on blood glucose levels and an indirect effect of stress on patient behaviors related to diabetes treatment and monitoring and meal and exercise plans. In contrast, there is no clear evidence that stressful life events promote the development of diabetes in children or in adults. Stress hyperglycemia, the development of hyperglycemia during acute illness, represents another interesting connection between the stress system and glucose homeostasis. A large body of evidence supports an association between stress hyperglycemia and increased morbidity and mortality in critically ill patients. Interestingly, there is some evidence supporting a beneficial effect of insulin in reducing morbidity and mortality in patients admitted to intensive care units. Finally, stress can influence the development of type 2 diabetes indirectly by promoting obesity and metabolic syndrome.
C1 [Marcovecchio, M. Loredana; Chiarelli, Francesco] Univ G dAnnunzio, Dept Paediat, I-66013 Chieti, Italy.
C3 G d'Annunzio University of Chieti-Pescara
RP Chiarelli, F (corresponding author), Univ G dAnnunzio, Dept Paediat, I-66013 Chieti, Italy.
EM chiarelli@unich.it
OI Maria Loredana, Marcovecchio/0000-0002-4415-316X
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NR 17
TC 52
Z9 60
U1 0
U2 39
PU AMER ASSOC ADVANCEMENT SCIENCE
PI WASHINGTON
PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA
SN 1945-0877
EI 1937-9145
J9 SCI SIGNAL
JI Sci. Signal.
PD OCT 23
PY 2012
VL 5
IS 247
AR pt10
DI 10.1126/scisignal.2003508
PG 3
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA 028VH
UT WOS:000310451800002
PM 23092890
DA 2025-06-11
ER

PT J
AU Reynolds, RM
AF Reynolds, Rebecca M.
TI Glucocorticoid excess and the developmental origin of disease: Two
   decades of testing the hypothesis-2012 Curt Richter Award Winner
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Review
DE Glucocorticoids; Hypothalami- pituitary-adrenal axis; Birthweight;
   Programming; Metabolic syndrome; Cognitive decline
ID CORTICOTROPIN-RELEASING HORMONE; PITUITARY-ADRENAL AXIS;
   LOW-BIRTH-WEIGHT; PLASMA-CORTISOL CONCENTRATIONS; CARDIOVASCULAR
   RISK-FACTORS; 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-2; MESSENGER-RNA
   EXPRESSION; RECEPTOR GENE-EXPRESSION; CORONARY-ARTERY-DISEASE; HEALTHY
   ELDERLY-MEN
AB Low birthweight, a marker of an adverse in utero environment, is associated with cardiometabolic disease and brain disorders in adulthood. The adaptive changes made by the fetus in response to the intra-uterine environment result in permanent changes in physiology, structure and metabolism, a phenomenon termed early life programming. One of the key hypotheses to explain programming, namely over exposure of the developing fetus to glucocorticoids, was proposed nearly two decades ago, following the observation that the fetus was protected from high glucocorticoid levels in the mother by the actions of the placental barrier enzyme, 11 beta-hydroxysteroid dehydrogenase, which converts active glucocorticoids into inactive products. Numerous mechanistic studies in animal models have been carried out to test this hypothesis using manipulations to increase maternal glucocorticoids. Overall, these have resulted in offspring of lower birthweight, with an activated hypothalamic-pituitary-adrenal (HPA) axis and an adverse metabolic profile and behavioural phenotype in adulthood.
   Altered glucocorticoid activity or action is a good candidate mechanism in humans to link low birthweight with cardiometabolic and brain disorders. We have carried out detailed studies in men and women showing that high levels of endogenous glucocorticoids, or treatment with exogenous glucocorticoids, is associated with an adverse metabolic profile, increased cardiovascular disease and altered mood and cognitive decline. Our laboratory carried out the first translational studies in humans to test the glucocorticoid hypothesis, firstly demonstrating in studies of adult men and women, that low birthweight was associated with high fasting cortisol levels. We went on to dissect the mechanisms underlying the high fasting cortisol, demonstrating activation of the HPA axis, with increased cortisol responses to stimulation with exogenous adrenocorticotrophin hormone, lack of habituation to the stress of venepuncture, and increased cortisol responses to psychosocial stress. We have developed new dynamic tests to dissect the mechanisms regulating HPA axis central negative feedback sensitivity in humans, and demonstrated that this may be altered in obesity, one component of the metabolic syndrome.
   There are now studies in humans demonstrating that high circulating levels of maternal cortisol during pregnancy correlate negatively with birthweight, suggesting that excess glucocorticoids can by-pass the placental barrier. Deficiencies in the barrier enzyme, potentially increasing fetal glucocorticoid exposure, can also arise in association with maternal stress, malnutrition and disease, and can be inhibited by consumption of liquorice, which contains glycyrrhizin, an HSD inhibitor. Importantly, studies in humans have now demonstrated that high maternal cortisol in pregnancy and/or inhibition of HSD2 are associated with programmed outcomes in childhood including higher blood pressure, behavioural disorders as well as altered brain structure. We are investigating this further, using novel magnetic resonance imaging techniques to study the developing fetal brain in utero.
   The translational studies in support of the glucocorticoid hypothesis, and demonstrating that glucocorticoids are both mediators and targets of programming, are exciting and raise the question of whether this information can be used to identify those individuals most at risk of later life disease. In a recent study we showed that alterations in DNA rnethylation at genes important in regulating cortisol levels, tissue glucocorticoid action, blood pressure and fetal growth, are present in adulthood in association with both early life parameters and cardiometabolic risk factors. These preliminary data add to the limited literature in humans indicating a persisting epigenetic link between early life events and subsequent disease risk. Such findings open novel avenues for further exploration of the contribution of glucocorticoids to later life disease. (C) 2012 Elsevier Ltd. All rights reserved.
C1 Univ BHF Ctr Cardiovasc Sci, Endocrinol Unit, Queens Med Res Inst, Edinburgh EH16 4TJ, Midlothian, Scotland.
C3 University of Edinburgh
RP Reynolds, RM (corresponding author), Univ BHF Ctr Cardiovasc Sci, Endocrinol Unit, Queens Med Res Inst, 47 Little France Crescent, Edinburgh EH16 4TJ, Midlothian, Scotland.
EM R.Reynolds@ed.ac.uk
RI Reynolds, Rebecca M/C-3044-2008
OI Reynolds, Rebecca M/0000-0001-6226-8270
FU Wellcome Trust; Medical Research Council; British Heart Foundation;
   Chief Scientist Office, Scotland
FX The studies reported in this manuscript were supported in part by grants
   from the Wellcome Trust, the Medical Research Council, the British Heart
   Foundation and the Chief Scientist Office, Scotland.
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PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD JAN
PY 2013
VL 38
IS 1
BP 1
EP 11
DI 10.1016/j.psyneuen.2012.08.012
PG 11
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA 073RU
UT WOS:000313761000001
PM 22998948
DA 2025-06-11
ER

PT J
AU Bourebaba, N
   Sikora, M
   Qasem, B
   Bourebaba, L
   Marycz, K
AF Bourebaba, Nabila
   Sikora, Mateusz
   Qasem, Badr
   Bourebaba, Lynda
   Marycz, Krzysztof
TI Sex hormone-binding globulin (SHBG) mitigates ER stress and improves
   viability and insulin sensitivity in adipose-derived mesenchymal stem
   cells (ASC) of equine metabolic syndrome (EMS)-affected horses
SO CELL COMMUNICATION AND SIGNALING
LA English
DT Article
DE EMS; ASC; SHBG; ER Stress; Apoptosis; PDIA3; Insulin resistance
ID OXIDATIVE STRESS; DIABETES-MELLITUS; PROTEIN; WOMEN; RESISTANCE;
   KINASES; PATHWAY; RISK
AB BackgroundEquine metabolic syndrome (EMS), which encompasses insulin resistance, low-grade inflammation and predisposition to laminitis is a critical endocrine disorder among the most prevalent conditions affecting horses from different breeds. According to the most recent research, low human sex hormone-binding globulin (SHBG) serum levels correlate with an increased risk of obesity, insulin resistance and diabetes, and may contribute to overall metabolic dysregulations. This study aimed to test whether exogenous SHBG could protect EMS affected adipose-derived stromal stem cells (EqASCEMS) from apoptosis, oxidative stress, ER stress and thus improve insulin sensitivity.MethodsEqASCEMS wells were treated with two different concentrations (50 and 100 nM) of exogenous SHBG, whose biocompatibility was tested after 24, 48 and 72 h of incubation. Several parameters including cell viability, apoptosis, cell cycle, reactive oxygen species levels, ER stress, Pi3K/MAPK activation and insulin transducers expression were analysed.ResultsObtained data demonstrated that exogenous SHBG treatment significantly promoted ASCs cells proliferation, cell cycle and survival with reduced expression of p53 and p21 pro-apoptotic mediators. Furthermore, SHBG alleviated the oxidative stress caused by EMS and reduced the overaccumulation of intracellular ROS, by reducing ROS + cell percentage and regulating gene expression of endogenous antioxidant enzymes (Sod 1, Cat, GPx), SHBG treatment exhibited antioxidant activity by modulating total nitric oxide (NO) levels in EMS cells as well. SHBG treatment dampened the activation of ER stress sensors and effectors in EqASCEMS cells via the upregulation of MiR-7a-5p, the decrease in the expression levels of ATF-6, CHOP and eiF2A and the restoration of PDIA3 chaperone protein levels. As a consequence, SHBG application substantially improved insulin sensitivity through the modulation of Pi3K/Akt/Glut4 insulin signalling cascades.ConclusionOur results suggest that the SHBG is endowed with crucial beneficial effects on ASCs metabolic activities and could serve as a valuable therapeutic target for the development of efficient EMS treatment protocols.1CMnBWH6nCsmkUsG-EU1vwVideo AbstractConclusionOur results suggest that the SHBG is endowed with crucial beneficial effects on ASCs metabolic activities and could serve as a valuable therapeutic target for the development of efficient EMS treatment protocols.1CMnBWH6nCsmkUsG-EU1vwVideo Abstract
C1 [Bourebaba, Nabila; Sikora, Mateusz; Qasem, Badr; Bourebaba, Lynda] Wroclaw Univ Environm & Life Sci, Fac Biol & Anim Sci, Dept Expt Biol, Norwida 27B, PL-50375 Wroclaw, Poland.
   [Marycz, Krzysztof] Univ Calif Davis, Dept Med & Epidemiol, Sch Vet Med, Davis, CA 95616 USA.
   [Marycz, Krzysztof] Univ Calif Davis, Vet Inst Regenerat Cures, Sch Vet Med, Dept Vet Med & Epidemiol, Davis, CA 95616 USA.
C3 Wroclaw University of Environmental & Life Sciences; University of
   California System; University of California Davis; University of
   California System; University of California Davis
RP Marycz, K (corresponding author), Univ Calif Davis, Dept Med & Epidemiol, Sch Vet Med, Davis, CA 95616 USA.; Marycz, K (corresponding author), Univ Calif Davis, Vet Inst Regenerat Cures, Sch Vet Med, Dept Vet Med & Epidemiol, Davis, CA 95616 USA.
EM kmmarycz@ucdavis.edu
RI Bourebaba, Nabila/JRY-9553-2023; Marycz, Krzysztof/A-2249-2017; Qasem,
   Badr/AAF-4418-2019; Bourebaba, Lynda/AAX-7613-2020
OI Qasem, Badr/0000-0001-7085-0287
FU Not Applicable.
FX Not Applicable.
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U1 3
U2 10
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1478-811X
J9 CELL COMMUN SIGNAL
JI Cell Commun. Signal.
PD SEP 11
PY 2023
VL 21
IS 1
AR 230
DI 10.1186/s12964-023-01254-6
PG 19
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA S3IP3
UT WOS:001070141900001
PM 37697311
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Mafra, D
   Borges, NA
   Alvarenga, L
   Ribeiro, M
   Fonseca, L
   Leal, VO
   Shiels, PG
   Stenvinkel, P
AF Mafra, D.
   Borges, N. A.
   Alvarenga, L.
   Ribeiro, M.
   Fonseca, L.
   Leal, V. O.
   Shiels, P. G.
   Stenvinkel, P.
TI Fermented food: Should patients with cardiometabolic diseases go back to
   an early neolithic diet?
SO CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
LA English
DT Review
DE Fermented food; gut microbiota; inflammation; oxidative stress;
   cardiometabolic diseases
ID LACTIC-ACID BACTERIA; DOSE-RESPONSE METAANALYSIS; RED WINE POLYPHENOLS;
   DOUBLE-BLIND; LOW-FAT; METABOLIC SYNDROME; OXIDATIVE STRESS; PROBIOTIC
   YOGURT; GUT-MICROBIOTA; LIPID PROFILE
AB Fermentation has been used since the Early Neolithic period to preserve foods. It has inherent organoleptic and nutritive properties that bestow health benefits, including reducing inflammation and oxidative stress, supporting the growth of salutogenic microbiota, enhancing intestinal mucosal protection and promoting beneficial immunometabolic health effects. The fermentation of food with specific microbiota increases the production salutogenic bioactive compounds that can activate Nrf2 mediated cytoprotective responses and mitigate the effects of the 'diseasome of aging' and its associated inflammageing, which presents as a prominent feature of obesity, type-2 diabetes, cardiovascular and chronic kidney disease. This review discusses the importance of fermented food in improving health span, with special reference to cardiometabolic diseases.
C1 [Mafra, D.; Alvarenga, L.; Fonseca, L.] Fed Fluminense Univ, Post Grad Program Med Sci, Niteroi, RJ, Brazil.
   [Mafra, D.; Ribeiro, M.] Fed Univ Rio de Janeiro UFRJ, Physiol, Grad Program Biol Sci, Rio De Janeiro, Brazil.
   [Borges, N. A.] Univ Estado Rio De Janeiro, Inst Nutr, Rio De Janeiro, Brazil.
   [Leal, V. O.] Univ Estado Rio De Janeiro, Pedro Ernesto Univ Hosp, Div Nutr, Rio De Janeiro, Brazil.
   [Shiels, P. G.] Univ Glasgow, Wolfson Wohl Translat Res Ctr, Glasgow, Lanark, Scotland.
   [Stenvinkel, P.] Karolinska Inst, Dept Clin Sci Technol & Intervent, Div Renal Med, Stockholm, Sweden.
C3 Universidade Federal Fluminense; Universidade Federal do Rio de Janeiro;
   Universidade do Estado do Rio de Janeiro; Universidade do Estado do Rio
   de Janeiro; University of Glasgow; Karolinska Institutet
RP Mafra, D (corresponding author), Fed Fluminense Univ, Post Grad Program Med Sci, Niteroi, RJ, Brazil.; Mafra, D (corresponding author), Fed Univ Rio de Janeiro UFRJ, Physiol, Grad Program Biol Sci, Rio De Janeiro, Brazil.
EM dmafra30@gmail.com
RI Borges, Natália/AFU-8397-2022; Leal, Viviane/MZR-0995-2025; Mafra,
   Denise/D-4923-2015
OI ALVARENGA, LIVIA/0000-0002-9347-8139; Fonseca,
   Larissa/0000-0002-9318-080X; Alvarenga Borges,
   Natalia/0000-0003-0898-5118; Shiels, Paul/0000-0002-7577-9843;
   Stenvinkel, Peter/0000-0002-8785-4820; Ferreira Ribeiro, Marcia
   Maria/0000-0002-4957-3630; Mafra, Denise/0000-0001-6752-6056
FU Conselho Nacional de Pesquisa (CNPq) [200162/2020-9]; Fundacao de Amparo
   a Pesquisa do Estado do Rio de Janeiro (FAPERJ) [E-26/202.524/2019]
FX This study was supported by Conselho Nacional de Pesquisa (CNPq) number
   200162/2020-9, and Fundacao de Amparo a Pesquisa do Estado do Rio de
   Janeiro (FAPERJ) number E-26/202.524/2019.
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NR 207
TC 5
Z9 5
U1 5
U2 65
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1040-8398
EI 1549-7852
J9 CRIT REV FOOD SCI
JI Crit. Rev. Food Sci. Nutr.
PD NOV 17
PY 2023
VL 63
IS 29
BP 10173
EP 10196
DI 10.1080/10408398.2022.2077300
EA MAY 2022
PG 24
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA HN6E5
UT WOS:000798134100001
PM 35593230
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Linta, AV
   Lolescu, BM
   Ilie, CA
   Vlad, M
   Blidisel, A
   Sturza, A
   Borza, C
   Muntean, DM
   Cretu, OM
AF Linta, Adina V.
   Lolescu, Bogdan M.
   Ilie, Cosmin A.
   Vlad, Mihaela
   Blidisel, Alexandru
   Sturza, Adrian
   Borza, Claudia
   Muntean, Danina M.
   Cretu, Octavian M.
TI Liver and Pancreatic Toxicity of Endocrine-Disruptive Chemicals: Focus
   on Mitochondrial Dysfunction and Oxidative Stress
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE endocrine disruptors; metabolism-disrupting chemicals; liver; pancreas;
   mitochondrial dysfunction; oxidative stress
ID BETA-CELL FUNCTION; BISPHENOL-A; PERINATAL EXPOSURE; FATTY LIVER;
   OBESITY; HEALTH; DAMAGE; RATS; METABOLISM; ATRAZINE
AB In recent years, the worldwide epidemic of metabolic diseases, namely obesity, metabolic syndrome, diabetes and metabolic-associated fatty liver disease (MAFLD) has been strongly associated with constant exposure to endocrine-disruptive chemicals (EDCs), in particular, the ones able to disrupt various metabolic pathways. EDCs have a negative impact on several human tissues/systems, including metabolically active organs, such as the liver and pancreas. Among their deleterious effects, EDCs induce mitochondrial dysfunction and oxidative stress, which are also the major pathophysiological mechanisms underlying metabolic diseases. In this narrative review, we delve into the current literature on EDC toxicity effects on the liver and pancreatic tissues in terms of impaired mitochondrial function and redox homeostasis.
C1 [Linta, Adina V.; Sturza, Adrian; Borza, Claudia; Muntean, Danina M.] Victor Babes Univ Med & Pharm Timisoara, Dept Funct Sci, Chair Pathophysiol, E Murgu Sq 2, Timisoara 300041, Romania.
   [Linta, Adina V.; Lolescu, Bogdan M.; Ilie, Cosmin A.; Sturza, Adrian; Borza, Claudia; Muntean, Danina M.] Victor Babes Univ Med & Pharm Timisoara, Ctr Translat Res & Syst Med, E Murgu Sq 2, Timisoara 300041, Romania.
   [Linta, Adina V.; Lolescu, Bogdan M.] Victor Babes Univ Med & Pharm Timisoara, Doctoral Sch Med Pharm, E Murgu Sq 2, Timisoara 300041, Romania.
   [Ilie, Cosmin A.] Victor Babes Univ Med & Pharm Timisoara, Chair Publ Hlth & Sanit Management, Dept Funct Sci, E Murgu Sq 2, Timisoara 300041, Romania.
   [Vlad, Mihaela] Victor Babes Univ Med & Pharm Timisoara, Chair Endocrinol, Dept Internal Med 2, E Murgu Sq 2, Timisoara 300041, Romania.
   [Blidisel, Alexandru; Cretu, Octavian M.] Victor Babes Univ Med & Pharm Timisoara, Chair Surg Semiot & Thorac Surg, Dept Surg 1, E Murgu Sq 2, Timisoara 300041, Romania.
   [Blidisel, Alexandru; Cretu, Octavian M.] Victor Babes Univ Med & Pharm Timisoara, Ctr Hepatobiliary & Pancreat Surg, E Murgu Sq 2, Timisoara 300041, Romania.
C3 Victor Babes University of Medicine & Pharmacy, Timisoara; Victor Babes
   University of Medicine & Pharmacy, Timisoara; Victor Babes University of
   Medicine & Pharmacy, Timisoara; Victor Babes University of Medicine &
   Pharmacy, Timisoara; Victor Babes University of Medicine & Pharmacy,
   Timisoara; Victor Babes University of Medicine & Pharmacy, Timisoara;
   Victor Babes University of Medicine & Pharmacy, Timisoara
RP Muntean, DM (corresponding author), Victor Babes Univ Med & Pharm Timisoara, Dept Funct Sci, Chair Pathophysiol, E Murgu Sq 2, Timisoara 300041, Romania.; Muntean, DM (corresponding author), Victor Babes Univ Med & Pharm Timisoara, Ctr Translat Res & Syst Med, E Murgu Sq 2, Timisoara 300041, Romania.
EM adina.linta@umft.ro; bogdan.lolescu@umft.ro; ilie.adrian@umft.ro;
   vlad.mihaela@umft.ro; blidy@umft.ro; sturza.adrian@umft.ro;
   borza.claudia@umft.ro; daninamuntean@umft.ro; octavian.cretu@umft.ro
RI Cretu, Octavian/LWH-8125-2024; Vlad, Mihaela/JAN-8553-2023; Sturza,
   Adrian/AAL-8869-2020; Muntean, Danina Mirela/G-3138-2016; Furdui'Linta,
   Adina/LSL-0957-2024; claudia, Borza/ABH-5975-2020
OI Blidisel, Alexandru/0000-0001-6528-7733; Vlad,
   Mihaela/0000-0002-0276-1650
FU The "Victor Babes," University of Medicine and Pharmacy of Timisoara
FX We would like to acknowledge the support of "Victor Babes," University
   of Medicine and Pharmacy of Timisoara, in covering the costs of
   publication for this paper.
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NR 120
TC 4
Z9 4
U1 10
U2 22
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD JUL
PY 2024
VL 25
IS 13
AR 7420
DI 10.3390/ijms25137420
PG 25
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA YP4G9
UT WOS:001269670300001
PM 39000526
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Deng, YW
   Liu, F
   Yang, XL
   Xia, YL
AF Deng, Yawen
   Liu, Fei
   Yang, Xiaolei
   Xia, Yunlong
TI The Key Role of Uric Acid in Oxidative Stress, Inflammation, Fibrosis,
   Apoptosis, and Immunity in the Pathogenesis of Atrial Fibrillation
SO FRONTIERS IN CARDIOVASCULAR MEDICINE
LA English
DT Review
DE uric acid; atrial fibrillation; mechanisms; oxidative stress;
   inflammation
ID MUSCLE-CELL-PROLIFERATION; C-REACTIVE PROTEIN; METABOLIC SYNDROME;
   XANTHINE-OXIDASE; CARDIOVASCULAR-DISEASE; INCREASED PREVALENCE;
   NITRIC-OXIDE; HYPERURICEMIA; ASSOCIATION; PATHOPHYSIOLOGY
AB Atrial fibrillation (AF) is a highly prevalent cardiac arrhythmia that leads to numerous adverse outcomes including stroke, heart failure, and death. Hyperuricemia is an important risk factor that contributes to atrium injury and AF, but the underlying molecular mechanism remains to be elucidated. In this review, we discussed the scientific evidence for clarifying the role of hyperuricemia in the pathogenesis of AF. Experimental and Clinical evidence endorse hyperuricemia as an independent risk factor for the incidence of AF. Various in vivo and in vitro investigations showed that hyperuricemia might play a critical role in the pathogenesis of AF at different UA concentrations through the activation of oxidative stress, inflammation, fibrosis, apoptosis, and immunity.
C1 [Deng, Yawen; Liu, Fei; Yang, Xiaolei; Xia, Yunlong] Dalian Med Univ, Affiliated Hosp 1, Dept Cardiol, Dalian, Peoples R China.
C3 Dalian Medical University
RP Yang, XL; Xia, YL (corresponding author), Dalian Med Univ, Affiliated Hosp 1, Dept Cardiol, Dalian, Peoples R China.
EM 15942456079@yeah.net; yunlong_xia@126.com
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NR 92
TC 51
Z9 55
U1 3
U2 37
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2297-055X
J9 FRONT CARDIOVASC MED
JI Front. Cardiovasc. Med.
PD FEB 26
PY 2021
VL 8
AR 641136
DI 10.3389/fcvm.2021.641136
PG 10
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA QU9CQ
UT WOS:000627578200001
PM 33718459
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Sarkar, P
   Basak, P
   Ghosh, S
   Kundu, M
   Sil, PC
AF Sarkar, Poulami
   Basak, Priyanka
   Ghosh, Sumit
   Kundu, Mousumi
   Sil, Parames C.
TI Prophylactic role of taurine and its derivatives against diabetes
   mellitus and its related complications
SO FOOD AND CHEMICAL TOXICOLOGY
LA English
DT Review
DE Taurine; Diabetes mellitus; Oxidative stress; Diabetic complications;
   Antioxidant; Hypoglycemic effect
ID GLYCATION END-PRODUCTS; NF-KAPPA-B; ENDOPLASMIC-RETICULUM STRESS;
   ATTENUATES OXIDATIVE STRESS; INDUCED HYPERTROPHIC GROWTH; INDUCED
   INSULIN-SECRETION; HIGH-GLUCOSE; TAUROURSODEOXYCHOLIC ACID;
   NITRIC-OXIDE; BILE-ACID
AB Taurine is a conditionally essential amino acid present in the body in free form. Mammalian taurine is synthesized in the pancreas via the cysteine sulfinic acid pathway. Anti-oxidation and anti-inflammation are two main properties through which it exerts its therapeutic effects. Many studies have shown its excellent therapeutic potential against diabetes mellitus and related complications like diabetic neuropathy, retinopathy, nephropathy, hematological dysfunctions, reproductive dysfunctions, liver and pancreas related complications etc. Not only taurine, a number of its derivatives have also been reported to be important in ameliorating diabetic complications. The present review has been aimed to describe the importance of taurine and its derivatives against diabetic metabolic syndrome and related complications.
C1 [Sarkar, Poulami; Basak, Priyanka; Ghosh, Sumit; Kundu, Mousumi; Sil, Parames C.] Bose Inst, Div Mol Med, P-1-12,CIT Scheme 7 M, Kolkata 700054, W Bengal, India.
C3 Department of Science & Technology (India); Bose Institute
RP Sil, PC (corresponding author), Bose Inst, Div Mol Med, P-1-12,CIT Scheme 7 M, Kolkata 700054, W Bengal, India.
EM parames@jcbose.ac.in
RI Sarkar, Poulami/KIC-9599-2024; Das, Joydeep/AAE-3501-2021; Ghosh,
   Sumit/MIQ-3051-2025
OI Ghosh, Sumit/0000-0002-9199-5941; Sarkar, Poulami/0009-0001-2874-0575
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NR 197
TC 51
Z9 52
U1 0
U2 23
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0278-6915
EI 1873-6351
J9 FOOD CHEM TOXICOL
JI Food Chem. Toxicol.
PD DEC
PY 2017
VL 110
BP 109
EP 121
DI 10.1016/j.fct.2017.10.022
PG 13
WC Food Science & Technology; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Toxicology
GA FQ2TU
UT WOS:000418211700011
PM 29050977
DA 2025-06-11
ER

PT J
AU Serafini, M
   Peluso, I
AF Serafini, Mauro
   Peluso, Ilaria
TI Functional Foods for Health: The Interrelated Antioxidant and
   Anti-Inflammatory Role of Fruits, Vegetables, Herbs, Spices and Cocoa in
   Humans
SO CURRENT PHARMACEUTICAL DESIGN
LA English
DT Review
DE Antioxidants; human; functional foods; inflammation; oxidative stress;
   plant foods
ID C-REACTIVE PROTEIN; GREEN TEA EXTRACT; NF-KAPPA-B; CARDIOVASCULAR
   RISK-FACTORS; RANDOMIZED CONTROLLED-TRIAL; TYPE-2 DIABETES-MELLITUS;
   PLACEBO-CONTROLLED TRIAL; GRAPE SEED EXTRACT; OXIDATIVE STRESS;
   METABOLIC SYNDROME
AB The health benefits of plant food-based diets could be related to both integrated antioxidant and antiinflammatory mechanisms exerted by a wide array of phytochemicals present in fruit, vegetables, herbs and spices. Therefore, there is mounting interest in identifying foods, food extracts and phytochemical formulations from plant sources which are able to efficiently modulate oxidative and inflammatory stress to prevent diet-related diseases. This paper reviews available evidence about the effect of supplementation with selected fruits, vegetables, herbs, spices and their extracts or galenic formulation on combined markers of redox and inflammatory status in humans.
C1 [Serafini, Mauro; Peluso, Ilaria] Council Agr Res & Econ, Ctr Food & Nutr, Funct Foods & Metab Stress Prevent Lab, Via Ardeatina 546, I-00176 Rome, Italy.
C3 Consiglio per la Ricerca in Agricoltura e L'analisi Dell'economia
   Agraria (CREA)
RP Serafini, M (corresponding author), Council Agr Res & Econ, Ctr Food & Nutr, Funct Foods & Metab Stress Prevent Lab, Via Ardeatina 546, I-00176 Rome, Italy.
EM serafini_mauro@yahoo.it
RI Peluso, Ilaria/ABE-3399-2021; Serafini, Mauro/K-6498-2018; Peluso,
   Ilaria/A-8023-2018
OI Serafini, Mauro/0000-0003-0913-936X; Peluso, Ilaria/0000-0002-6210-5241
FU PGT Healthcare
FX Editorial assistance was provided by Luca Giacomelli, PhD, on behalf of
   Content Ed Net; this assistance was funded by PGT Healthcare.
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NR 120
TC 150
Z9 156
U1 4
U2 78
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1381-6128
EI 1873-4286
J9 CURR PHARM DESIGN
JI Curr. Pharm. Design
PY 2016
VL 22
IS 44
BP 6701
EP 6715
DI 10.2174/1381612823666161123094235
PG 15
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA EI9TK
UT WOS:000392851800009
PM 27881064
OA Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Adekunle, OA
   Wang, YS
   Yunusa, I
   Fleming, ML
   Seoane-Vazquez, E
   Brown, LM
AF Adekunle, Olajide A.
   Wang, Yun S.
   Yunusa, Ismaeel
   Fleming, Marc L.
   Seoane-Vazquez, Enrique
   Brown, Lawrence M.
TI Predisposing, enabling, and need factors influencing health-related
   quality of life among people with metabolic syndrome
SO JOURNAL OF THE AMERICAN PHARMACISTS ASSOCIATION
LA English
DT Article
ID NUTRITION EXAMINATION SURVEY; TYPE-2 DIABETIC-PATIENTS; NATIONAL-HEALTH;
   UNITED-STATES; BEHAVIORAL-MODEL; PREVALENCE; OBESITY; IMPACT; ADULTS;
   LEVEL
AB Background: Metabolic syndrome (MetS) continues to impact the health-related quality of life (HRQoL) of patients despite various available therapeutic interventions. There is a dearth of information on how patient-centered factors holistically predict HRQoL to provide more insights on addressing MetS. Objective: To predict the HRQoL of patients with MetS in the Southern states, using the predisposing, enabling, and need factors. Methods: The study adopted a cross-sectional approach in collecting 706 complete surveys on HRQoL assessment using the EQ-5D-5L survey and demographic characteristics based on the predisposing, enabling, and need factors of Andersen's Behavioral model. The study focused on people with MetS in the southern states of the United States. Multinomial logistic regression was conducted to investigate the relationship between the number of comorbidities and each HRQoL dimension. Ordinal regression was used to explore factors predicting HRQoL. Sensitivity analysis was conducted using bootstrapping analysis to evaluate the regression's robustness. Results: Over 70% were females and 30% had at least a bachelor's degree, while 47% were married. Most respondents (71.1%) had no problem with self-care. However, 20.0% had severe problems with pain, while the highest proportion (8.6%) was observed for extreme problems with anxiety or depression. A unit increase in comorbidities resulted in higher odds of having extreme problems with mobility (odds ratio [OR] = 1.95), usual activities (OR = 1.73), and pain (OR = 1.70). Only 40.8% of the respondents had good HRQoL, compared to 26.2% with poor HRQoL. Age, race, geographical area, marital status, household income, number of prescription drugs, comorbidities, and body mass index were predictors of HRQoL. Conclusion: An increase in comorbidities significantly increased the odds of having challenges with the HRQoL dimensions. Demographic, socioeconomic, and health-related factors significantly predicted HRQoL. Therefore, health care providers must consider these factors as a component of patient-centered care to address health disparities and promote optimal health outcomes among people with MetS. (c) 2024 American Pharmacists Association (R). Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
C1 [Brown, Lawrence M.] Chapman Univ, Sch Pharm, Dept Pharmaceut Econ & Policy, Undergraduate Pharm Programs & Partnerships, 9401 Jeronimo Rd, Irvine, CA 92618 USA.
   [Wang, Yun S.] Chapman Univ, Sch Pharm, Dept Biomed & Pharmaceut Sci, Irvine, CA USA.
   [Yunusa, Ismaeel] Univ South Carolina, Coll Pharm, Clin Pharm & Outcomes Sci CPOS, Columbia, SC USA.
   [Fleming, Marc L.] Chapman Univ, Sch Pharm, Dept Pharmaceut Econ & Policy, Irvine, CA USA.
   [Seoane-Vazquez, Enrique] Chapman Univ, Sch Pharm, Dept Pharmaceut Econ & Policy, Irvine, CA USA.
C3 Chapman University System; Chapman University; Chapman University
   System; Chapman University; University of South Carolina System;
   University of South Carolina Columbia; Chapman University System;
   Chapman University; Chapman University System; Chapman University
RP Brown, LM (corresponding author), Chapman Univ, Sch Pharm, Dept Pharmaceut Econ & Policy, Undergraduate Pharm Programs & Partnerships, 9401 Jeronimo Rd, Irvine, CA 92618 USA.
EM lbbrown@chapman.edu
RI YUN, WANG/AEQ-2146-2022; Yunusa, Ismaeel/X-2390-2019
OI Adekunle, Olajide/0000-0003-2627-300X; WANG, YUN/0000-0001-9438-5586;
   Yunusa, Ismaeel/0000-0002-9107-8561
FU Chapman University
FX The study was supported by Chapman University.
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NR 75
TC 0
Z9 0
U1 0
U2 1
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1544-3191
EI 1544-3450
J9 J AM PHARM ASSOC
JI J. Am. Pharm. Assoc.
PD JAN-FEB
PY 2025
VL 65
IS 1
AR 102255
DI 10.1016/j.japh.2024.102255
EA NOV 2024
PG 10
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA L4S1W
UT WOS:001350623400001
PM 39384038
DA 2025-06-11
ER

PT J
AU Siqueira, JS
   Palacio, TLN
   Vieira, TA
   Nakandakare-Maia, ET
   Grandini, NA
   Ferron, AJT
   Francisqueti-Ferron, FV
   Correa, CR
AF Siqueira, Juliana Silva
   Palacio, Thiago Luiz Novaga
   Vieira, Taynara Aparecida
   Nakandakare-Maia, Erika Tiemi
   Grandini, Nubia Alves
   Ferron, Artur Junio Togneri
   Francisqueti-Ferron, Fabiane Valentini
   Correa, Camila Renata
TI An overview of the complex interaction between obesity and target organ
   dysfunction: focus on redox-inflammatory state
SO NUTRIRE
LA English
DT Review
DE Inflammation; Oxidative stress; Adipokines
ID NONALCOHOLIC FATTY LIVER; NECROSIS-FACTOR-ALPHA; BROWN ADIPOSE-TISSUE;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; HEART-FAILURE; METABOLIC SYNDROME;
   DISEASE; LEPTIN; MECHANISMS
AB The high consumption of simple carbohydrates and saturated fat is associated with a positive energy balance and fat accumulation. This scenario has been contributing to increase obesity rates in the world population in the last decades. Adipose tissue dysfunction has been associated with early stages of obesity-associated comorbidities due to several direct and indirect mechanisms, such as unregulated adipokine secretion, macrophage infiltration, inflammation, reduced antioxidant defense, and oxidative stress. These conditions can result in several metabolic disorders, among them, hypertension, dyslipidemia, insulin resistance besides with tissue and organ dysfunction. Thus, the better understanding of the processes involved in the pathophysiology of obesity and adipose tissue dysfunction can help in preventive and treatment studies in order to reduce obesity consequences.
C1 [Siqueira, Juliana Silva; Palacio, Thiago Luiz Novaga; Vieira, Taynara Aparecida; Nakandakare-Maia, Erika Tiemi; Grandini, Nubia Alves; Correa, Camila Renata] Sao Paulo State Univ UNESP, Botucatu Med Sch, Prof Montenegro Ave, BR-18618687 Botucatu, Brazil.
   [Ferron, Artur Junio Togneri] Integrated Coll Bauru FIB, Dept Phys Educ, BR-17056100 Bauru, Brazil.
   [Francisqueti-Ferron, Fabiane Valentini] Integrated Coll Bauru FIB, Dept Nutr, BR-17056100 Bauru, Brazil.
C3 Universidade Estadual Paulista
RP Siqueira, JS (corresponding author), Sao Paulo State Univ UNESP, Botucatu Med Sch, Prof Montenegro Ave, BR-18618687 Botucatu, Brazil.
EM juliana.siqueira@unesp.br
RI Correa, Camila/Q-2071-2019; Siqueira, Juliana/AAR-7994-2021; Alves
   Grandini, Nubia/HHZ-5975-2022; Francisqueti- Ferron,
   Fabiane/M-4919-2017; Novaga Palacio, Thiago Luiz/AGP-5802-2022;
   Aparecida Vieira, Taynara/JFK-7958-2023; Ferron, Artur Junio/M-5194-2017
OI Alves Grandini, Nubia/0000-0002-1696-4993; Correa, Camila
   Renata/0000-0001-8493-5329; Francisqueti- Ferron,
   Fabiane/0000-0003-2910-4308; Nakandakare Maia, Erika
   Tiemi/0000-0003-1253-001X; Novaga Palacio, Thiago
   Luiz/0000-0001-9568-7156; Aparecida Vieira, Taynara/0000-0002-5312-0060;
   Ferron, Artur Junio/0000-0001-7089-3033; Silva Siqueira,
   Juliana/0000-0003-3172-2199
FU Sao Paulo Research Foundation (FAPESP) [2021/07282-8]
FX This work is supported by the Sao Paulo Research Foundation (FAPESP),
   grant #2021/07282-8.
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NR 113
TC 4
Z9 4
U1 2
U2 3
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
EI 2316-7874
J9 NUTRIRE
JI Nutrire
PD APR 10
PY 2023
VL 48
IS 1
AR 21
DI 10.1186/s41110-023-00206-x
PG 13
WC Food Science & Technology; Nutrition & Dietetics
WE Emerging Sources Citation Index (ESCI)
SC Food Science & Technology; Nutrition & Dietetics
GA XA2E8
UT WOS:001258886600001
DA 2025-06-11
ER

PT J
AU Shi, SB
   Li, L
   Song, LN
   Wang, XR
AF Shi, Shaobo
   Li, Lu
   Song, Lina
   Wang, Xinrui
TI Effect of lamotrigine on cognitive function and serum inflammatory
   factors in patients with depression of recurrent bipolar disorder
SO PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES
LA English
DT Article
DE Bipolar disorder; lamotrigine; cognitive function; inflammatory factors
ID METABOLIC SYNDROME; RISK
AB In the present study, an effort was made to investigate the effect of lamotrigine on cognitive function and serum inflammatory factors in patients with depression of recurrent bipolar disorder and to explore its possible mechanism.140 patients with depression of recurrent bipolar disorder, admitted from June 2015 to April 2017, were selected as the research subjects, followed by random division into the research group and the control group with 70 cases (n=70) in each group. The control group was treated with sodium valproate and the research group was treated with lamotrigine. After 2 months of treatment, comparison was made between the two groups for the emotional state, cognitive function and serum inflammatory factors. Results showed that the Hamilton Depression Scale (HAMD) score and Bech-Rafaelsen Mania Rating Scale BRMS score in the research group were significantly lower than in the control group (P<0.05). The time of Trail Making Test-A(TMT-A) and Trail Making Test-B(TMT-B) in the research group was significantly shorter than that of the control group, with a statistically significant difference (P<0.05). The serum levels of MIF, IL-1 beta and IL-6 in the research group were significantly lower than those in the control group and the difference was statistically significant (P<0.05). Research concluded that lamotrigine may help alleviate the clinical symptoms and improve cognitive function in patients with depression of recurrent bipolar disorder.
C1 [Shi, Shaobo; Li, Lu; Song, Lina; Wang, Xinrui] Mental Hlth Ctr Qingdao, Dept Psychiat, Qingdao, Peoples R China.
RP Shi, SB (corresponding author), Mental Hlth Ctr Qingdao, Dept Psychiat, Qingdao, Peoples R China.
EM sci477@aliyun.com
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Z9 8
U1 1
U2 4
PU UNIV KARACHI
PI KARACHI
PA UNIV CAMPUS, FAC PHARMACY, KARACHI, 75270, PAKISTAN
SN 1011-601X
J9 PAK J PHARM SCI
JI Pak. J. Pharm. Sci.
PD NOV
PY 2018
VL 31
IS 6
SI SI
BP 2775
EP 2778
PG 4
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA HI5KY
UT WOS:000456492100003
PM 30630782
DA 2025-06-11
ER

PT J
AU Reljic, D
   Koller, A
   Herrmann, HJ
   Ekici, AB
   Neurath, MF
   Zopf, Y
AF Reljic, Dejan
   Koller, Adriana
   Herrmann, Hans J.
   Ekici, Arif B.
   Neurath, Markus F.
   Zopf, Yurdagul
TI Differential Effects of Very-Low-Volume Exercise Modalities on Telomere
   Length, Inflammation, and Cardiometabolic Health in Obese Metabolic
   Syndrome Patients: A Subanalysis from Two Randomized Controlled Trials
SO ANTIOXIDANTS
LA English
DT Article
DE telomeres; cellular age; high-intensity interval training; resistance
   training; electromyostimulation; metabolic diseases; oxidative stress;
   inflammatory markers; anti-aging
ID C-REACTIVE PROTEIN; PHYSICAL-ACTIVITY; OXIDATIVE STRESS; PERCEIVED
   EXERTION; GENDER-DIFFERENCES; RISK-FACTORS; WEIGHT-LOSS; INTENSITY;
   ASSOCIATION; ADULTS
AB Oxidative stress (OS) and inflammation are features of metabolic syndrome (MetS) that can contribute to the shortening of telomere length (TL), a marker of cellular ageing. Research indicates that exercise can positively influence MetS-associated conditions and TL. However, the effects of low-volume exercise types on TL are still unknown. We investigated the impact of very-low-volume high-intensity interval training (LV-HIIT), one-set resistance training (1-RT), and whole-body electromyostimulation (WB-EMS) on TL, inflammation, and cardiometabolic indices in 167 MetS patients. Data were derived from two randomized controlled trials where patients were allocated to an exercise group (2 sessions/week, for 12 weeks) or a control group. All groups received standard-care nutritional weight loss counselling. TL was determined as the T/S ratio (telomere to single-copy gene amount). All groups significantly reduced body weight (p < 0.05), but the T/S-ratio (p < 0.001) only increased with LV-HIIT. OS-related inflammatory markers (C-reactive protein, interleukin-6, and lipopolysaccharide-binding protein) only decreased (p < 0.05) following LV-HIIT. The MetS severity z-score improved with LV-HIIT (p < 0.001) and 1-RT (p = 0.014) but not with WB-EMS. In conclusion, very-low-volume exercise modalities have differential effects on telomeres, inflammation, and cardiometabolic health. Only LV-HIIT but not strength-based low-volume exercise increased TL in MetS patients, presumably due to superior effects on OS-related inflammatory markers.
C1 [Reljic, Dejan; Herrmann, Hans J.; Neurath, Markus F.; Zopf, Yurdagul] Friedrich Alexander Univ Erlangen Nurnberg, Univ Hosp Erlangen, Dept Med 1, D-91054 Erlangen, Germany.
   [Reljic, Dejan; Herrmann, Hans J.; Zopf, Yurdagul] Friedrich Alexander Univ Erlangen Nurnberg, Univ Hosp Erlangen, Hector Ctr Nutr Exercise & Sports, Dept Med 1, D-91054 Erlangen, Germany.
   [Reljic, Dejan; Herrmann, Hans J.; Neurath, Markus F.; Zopf, Yurdagul] Friedrich Alexander Univ Erlangen Nurnberg, Univ Hosp Erlangen, German Ctr Immunotherapy DZI, D-91054 Erlangen, Germany.
   [Koller, Adriana] Med Univ Innsbruck, Inst Genet Epidemiol, A-6020 Innsbruck, Austria.
   [Ekici, Arif B.] Friedrich Alexander Univ Erlangen Nurnberg, Univ Hosp Erlangen, Inst Human Genet, D-91054 Erlangen, Germany.
C3 University of Erlangen Nuremberg; University of Erlangen Nuremberg;
   University of Erlangen Nuremberg; Medical University of Innsbruck;
   University of Erlangen Nuremberg
RP Reljic, D (corresponding author), Friedrich Alexander Univ Erlangen Nurnberg, Univ Hosp Erlangen, Dept Med 1, D-91054 Erlangen, Germany.; Reljic, D (corresponding author), Friedrich Alexander Univ Erlangen Nurnberg, Univ Hosp Erlangen, Hector Ctr Nutr Exercise & Sports, Dept Med 1, D-91054 Erlangen, Germany.; Reljic, D (corresponding author), Friedrich Alexander Univ Erlangen Nurnberg, Univ Hosp Erlangen, German Ctr Immunotherapy DZI, D-91054 Erlangen, Germany.
EM dejan.reljic@uk-erlangen.de; adriana.koller@i-med.ac.at;
   hans.herrmann@uk-erlangen.de; arif.ekici@uk-erlangen.de;
   yurdaguel.zopf@uk-erlangen.de
RI Reljic, Dejan/CAG-1377-2022; Ekici, Arif/C-3971-2013
OI Reljic, Dejan/0000-0001-8049-1775; Zopf, Yurdagul/0000-0002-3432-7488;
   Koller, Adriana/0000-0002-5595-4376; Herrmann, Hans
   Joachim/0000-0002-3021-8022; Ekici, Arif/0000-0001-6099-7066
FU The authors greatly appreciate the valuable support of the following
   persons who contributed to the implementation of this study: Walburga
   Dieterich for setting up and supervising the measurements of the
   inflammatory biomarkers; Alisia Gerl, Melanie Klaus
FX The authors greatly appreciate the valuable support of the following
   persons who contributed to the implementation of this study: Walburga
   Dieterich for setting up and supervising the measurements of the
   inflammatory biomarkers; Alisia Gerl, Melanie Klau ss ner, Maike
   Tobschall, and Kerstin Weidlich for supervising and instructing the
   exercise sessions; and Kathinka Faustka and Julia Kratzer for their
   assistance in data collection. We especially thank all patients for
   their willingness to participate in this investigation.
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NR 136
TC 3
Z9 3
U1 0
U2 6
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD OCT
PY 2023
VL 12
IS 10
AR 1847
DI 10.3390/antiox12101847
PG 22
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA X4PY3
UT WOS:001098299300001
PM 37891926
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Schinzari, F
   Tesauro, M
   Rovella, V
   Galli, A
   Mores, N
   Porzio, O
   Lauro, D
   Cardillo, C
AF Schinzari, Francesca
   Tesauro, Manfredi
   Rovella, Valentina
   Galli, Angelica
   Mores, Nadia
   Porzio, Ottavia
   lauro, DaviDe
   Cardillo, Carmine
TI Generalized impairment of vasodilator reactivity during hyperinsulinemia
   in patients with obesity-related metabolic syndrome
SO AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
LA English
DT Article
DE insulin; oxidative stress; vasodilation
ID TUMOR-NECROSIS-FACTOR; SMOOTH-MUSCLE-CELLS; INSULIN-RESISTANCE;
   PERIVASCULAR FAT; NITRIC-OXIDE; FACTOR-ALPHA; DYSFUNCTION; EXPRESSION;
   HUMANS; HYPERTENSION
AB Defective insulin-dependent vasodilation might contribute importantly to metabolic and vascular abnormalities of the metabolic syndrome (MetS). However, despite extensive investigation, the precise mechanisms involved in insulin's vasoactive effects have not been fully elucidated. Therefore, this study sought to better characterize insulin's physiological actions on vascular reactivity and their potential derangement in the MetS. Forearm blood flow responses to graded doses of acetylcholine, sodium nitroprusside, and verapamil were assessed by strain-gauge plethysmography in patients with obesity-related MetS (n = 20) and in matched controls (n = 18) before and after intra-arterial infusion of insulin (0.2 mU.kg(-1).min(-1)). Possible involvement of increased oxidative stress in the impaired insulin-stimulated vasodilator responsiveness of patients with MetS (n = 12) was also investigated using vitamin C (25 mg/min). In control subjects, significant potentiation of the vasodilator responses to acetylcholine, nitroprusside, and verapamil was observed after insulin infusion (all P < 0.05). However, no significant change in vasodilator reactivity to either of these drugs was observed following hyperinsulinemia in patients with MetS (all P > 0.05). Interestingly, administration of vitamin C to patients with MetS during hyperinsulinemia significantly enhanced the vasodilator responsiveness to acetylcholine, nitroprusside, and verapamil (all P < 0.05 vs. hyperinsulinemia alone). In conclusion, insulin exerts a generalized facilitatory action on vasodilator reactivity, and this effect is impaired in patients with MetS likely because of increased oxidative stress. Given the importance of vasodilator reactivity in affecting glucose disposal and vascular homeostasis, this defect may then contribute to the development of metabolic and vascular complications in insulin-resistant states.
C1 [Schinzari, Francesca; Cardillo, Carmine] Univ Cattolica Sacro Cuore, Sch Med, Dept Internal Med, Rome, Italy.
   [Mores, Nadia] Univ Cattolica Sacro Cuore, Sch Med, Dept Pharmacol, Rome, Italy.
   [Tesauro, Manfredi; Rovella, Valentina; Galli, Angelica; lauro, DaviDe] Univ Roma Tor Vergata, Dept Internal Med, Rome, Italy.
   [Porzio, Ottavia] Univ Roma Tor Vergata, Dept Biochem, Rome, Italy.
C3 Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli;
   Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli;
   University of Rome Tor Vergata; University of Rome Tor Vergata
RP Cardillo, C (corresponding author), Univ Cattolica Sacro Cuore, Ist Patol Speciale Med & Semeiot Med, Largo Gemelli 8, I-00168 Rome, Italy.
EM carmine.cardillo@rm.unicatt.it
RI schinzari, francesca/AAB-9982-2019; Rovella, Valentina/AAB-9727-2019
OI MORES, Nadia/0000-0002-4197-0914; PORZIO, OTTAVIA/0000-0001-5931-8679;
   Lauro, Davide/0000-0002-8597-4415; Rovella,
   Valentina/0000-0002-3311-486X; Cardillo, Carmine/0000-0001-5182-3005
FU Universita Cattolica del Sacro Cuore; Italian Ministero dell'Istruzione
FX This work was partially supported by Fondi d'Ateneo grants from the
   Universita Cattolica del Sacro Cuore and by a PRIN 2007 grant from the
   Italian Ministero dell'Istruzione to C. Cardillo.
CR BARON AD, 1995, J CLIN INVEST, V96, P786, DOI 10.1172/JCI118124
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NR 27
TC 49
Z9 50
U1 0
U2 1
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0193-1849
EI 1522-1555
J9 AM J PHYSIOL-ENDOC M
JI Am. J. Physiol.-Endocrinol. Metab.
PD DEC
PY 2010
VL 299
IS 6
BP E947
EP E952
DI 10.1152/ajpendo.00426.2010
PG 6
WC Endocrinology & Metabolism; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Physiology
GA 700CN
UT WOS:000285710400010
PM 20923961
DA 2025-06-11
ER

PT J
AU Mohamed, SM
   Shalaby, MA
   El-Shiekh, RA
   Bakr, AF
   Kamel, S
   Emam, SR
   El-Banna, HA
AF Mohamed, Salma Mostafa
   Shalaby, Mostafa Abbas
   El-Shiekh, Riham A.
   Bakr, Alaa F.
   Kamel, Shaimaa
   Emam, Shimaa R.
   El-Banna, Hossny A.
TI Maca roots: A potential therapeutic in the management of metabolic
   disorders through the modulation of metabolic biochemical markers in
   rats fed high-fat high-carbohydrate diet
SO JOURNAL OF ETHNOPHARMACOLOGY
LA English
DT Article
DE Maca roots; Metabolic syndrome; Insulin resistance; Lipid profile; Blood
   glucose; HFCD/STZ rat model
ID EXTRACT
AB Ethnopharmacological relevance: Maca root (Lepidium meyenii Walp.) is a Peruvian plant of the Brassicaceae family. Maca roots are popular food supplements used to treat a variety of ailments described traditionally as enhancing metabolic and health conditions. Aim of the study: Metabolic syndrome (MetS) has been the real scourge globally, affecting more than one-fourth of the global population. MetS causes the development of multi-organ illnesses, including altered blood cholesterol and sugar levels, oxidative stress, and hypertension. This study evaluated maca root total methanolic extract (MTE) as a potential nutraceutical to manage the complications of MetS. Materials and methods: After the first 4 weeks of a high-fat high-carbohydrate diet (HFCD), streptozotocin (STZ) was injected in Wistar rats to induce the MetS model. Animals were treated orally with MTE at 100 mg/kg and 300 mg/kg for 4 weeks compared to metformin at 200 mg/kg after confirmation of diabetes. Results: One month of MTE supplementation in HFCD-fed rats remarkably decreased the elevation of blood glucose and lipids, improved liver function and insulin resistance, additionally it successfully restored the state of inflammatory and oxidative stress. The extract was standardized to contain total phenolics equal to 24.45 +/- 0.96 mu g Gallic acid/mg extract. Conclusions: Our findings suggest that MTE improves MetS by reducing hyperglycemia, hyperlipidemia, inflammation, and oxidative stress. While also improving beta cell secretory functions, implying that MTE could be used as a balancing drug in the prevention and treatment of metabolic abnormalities linked to type 2 diabetes.
C1 [Mohamed, Salma Mostafa; Shalaby, Mostafa Abbas; Emam, Shimaa R.; El-Banna, Hossny A.] Cairo Univ, Fac Vet Med, Dept Pharmacol, 12211 Giza, Egypt.
   [El-Shiekh, Riham A.] Cairo Univ, Fac Pharm, Dept Pharmacognosy, Cairo 11562, Egypt.
   [Bakr, Alaa F.] Cairo Univ, Fac Vet Med, Dept Pathol, Cairo, Egypt.
   [Kamel, Shaimaa] Cairo Univ, Fac Vet Med, Dept Biochem & Mol Biol, Giza 12211, Egypt.
C3 Egyptian Knowledge Bank (EKB); Cairo University; Egyptian Knowledge Bank
   (EKB); Cairo University; Egyptian Knowledge Bank (EKB); Cairo
   University; Egyptian Knowledge Bank (EKB); Cairo University
RP El-Shiekh, RA (corresponding author), Cairo Univ, Fac Pharm, Dept Pharmacognosy, Cairo 11562, Egypt.
EM Salmamostafa14@hotmail.com; m_shalaby_1@outlook.com;
   riham.adel@pharma.cu.edu.eg; alaa.fouad1991@gmail.com;
   shaimaa.kamel@cu.edu.eg; shimaaramadan@cu.edu.eg; drelbanna3@cu.edu.eg
RI Shalaby, Drmostafa/S-9823-2019; R Emam, Shimaa/LQK-0944-2024; El Banna,
   Hossny/AAV-5079-2020; Kamel, Shaimaa/T-6308-2019
OI Ramadan, Shimaa/0000-0003-3860-3571; , Shaimaa/0000-0002-7414-3034;
   ElBanna, Hossny/0000-0003-4476-7775
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NR 60
TC 6
Z9 6
U1 1
U2 5
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0378-8741
EI 1872-7573
J9 J ETHNOPHARMACOL
JI J. Ethnopharmacol.
PD MAR 1
PY 2024
VL 321
AR 117533
DI 10.1016/j.jep.2023.117533
EA DEC 2023
PG 14
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA DP2Q7
UT WOS:001133198600001
PM 38056538
DA 2025-06-11
ER

PT J
AU Zhu, Y
   Huang, YB
   Santos, HO
   de Oliveira, CVC
   Zhou, H
   Tang, NI
AF Zhu, Ying
   Huang, Yubing
   Santos, Heitor O.
   de Oliveira, Caio V. C.
   Zhou, Hui
   Tang, Nie
TI Effects of purslane supplementation on C-reactive protein levels and
   biomarkers of oxidative stress as marks for metabolic syndrome: A
   systematic review and meta-analysis of randomized controlled trials
SO PHYTOTHERAPY RESEARCH
LA English
DT Review
DE C-reactive protein; endocrine syndrome; meta-analysis; oxidative stress;
   Portulaca oleracea; purslane
ID PORTULACA-OLERACEA L.; TYPE-2 DIABETES-MELLITUS; SEEDS
AB The antioxidant and antiinflammatory properties of purslane (Portulaca oleracea L.) are known in preclinical studies but further examination is needed to expand their potential into the clinical scenario. A systematic review and meta-analysis of randomized controlled trials were performed to elucidate the effects of purslane supplementation on C-reactive protein (CRP) levels and biomarkers of oxidative stress in metabolic syndrome, its related complications, and other diseases. PubMed/MEDLINE, Web of Science, SCOPUS, and Embase were the databases searched. Heterogeneity was examined using the I-squared (I-2) statistic, in which the source of heterogeneity was determined if the I-2-value was >50%. After all the screening processes, 10 studies met the eligibility criteria and were analyzed. Following purslane supplementation, CRP levels decreased significantly (weighted mean difference [WMD]: -0.33 mg/dl, 95% confidence interval [CI]: -0.66, -0.004, p = .047) but with significant heterogeneity (I-2 = 87.4%, p = .001). Purslane supplementation did not significantly change serum levels of malondialdehyde (MDA) (WMD: -0.353 mu m/L; 95% CI: -0.920, 0.213; I-2 = 50.7%), total antioxidant capacity (TAC) (WMD: 0.090 mm/L, 95% CI: -0.081, 0.262; I-2 = 47.1%), and superoxide dismutase (SOD) (WMD: 6.54 U/ml, 95% CI: -22.150, 35.236; I-2 = 70.7%). Thus, this meta-analysis showed a positive effect of purslane supplementation as a tool to decrease CRP levels, but not to MDA, TAC, and SOD levels.
C1 [Zhu, Ying; Zhou, Hui; Tang, Nie] Univ Elect Sci & Technol China, Chinese Acad Sci, Sichuan Translat Med Res Hosp, Sichuan Prov Peoples Hosp,Dept Endocrinol, Chengdu 610072, Peoples R China.
   [Huang, Yubing] Hainan Med Univ, Hainan Affiliated Hosp, Hainan Gen Hosp, Dept Cardiol, Haikou, Hainan, Peoples R China.
   [Santos, Heitor O.] Fed Univ Uberlandia UFU, Sch Med, Uberlandia, MG, Brazil.
   [de Oliveira, Caio V. C.] Ctr Univ Facisa Unifacisa, Campina Grande, Paraiba, Brazil.
C3 Sichuan Provincial People's Hospital; Chinese Academy of Sciences;
   University of Electronic Science & Technology of China; Hainan Medical
   University; Universidade Federal de Uberlandia
RP Zhou, H; Tang, NI (corresponding author), Univ Elect Sci & Technol China, Chinese Acad Sci, Sichuan Translat Med Res Hosp, Sichuan Prov Peoples Hosp,Dept Endocrinol, Chengdu 610072, Peoples R China.
EM fpxzzhou@163.com; 39tangdawn@sina.com
FU Sichuan Provincial Science and Technology Department [2017FZ0039];
   Sichuan Academy of Medical Sciences/Sichuan Provincial People's Hospital
   [2021QN1]
FX This study was supported by Sichuan Provincial Science and Technology
   Department (No. 2017FZ0039), and Sichuan Academy of Medical
   Sciences/Sichuan Provincial People's Hospital (No. 2021QN1).
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NR 52
TC 14
Z9 14
U1 0
U2 10
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0951-418X
EI 1099-1573
J9 PHYTOTHER RES
JI Phytother. Res.
PD OCT
PY 2021
VL 35
IS 10
BP 5477
EP 5486
DI 10.1002/ptr.7182
EA JUN 2021
PG 10
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA WL6EZ
UT WOS:000659375700001
PM 34109686
DA 2025-06-11
ER

PT J
AU Jialal, I
   Devaraj, S
   Adams-Huet, B
   Chen, XP
   Kaur, H
AF Jialal, Ishwarlal
   Devaraj, Sridevi
   Adams-Huet, Beverley
   Chen, Xinpu
   Kaur, Harmeet
TI Increased Cellular and Circulating Biomarkers of Oxidative Stress in
   Nascent Metabolic Syndrome
SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Article
ID LOW-DENSITY-LIPOPROTEIN; INSULIN-RESISTANCE; DIABETIC-PATIENTS; OBESITY;
   COMPLICATIONS; NITROTYROSINE; MITOCHONDRIA; INFLAMMATION; ASSOCIATION;
   ACTIVATION
AB Context: Metabolic syndrome (MetS) confers a greater risk for both cardiovascular disease (CVD) and diabetes. Oxidative stress (OS) could contribute to this excess risk. However, there are few data examining both cellular and circulating biomarkers of OS in MetS uncomplicated by diabetes and CVD.
   Objective: The aim of the study was to evaluate both cellular and circulating biomarkers of OS in MetS uncomplicated by diabetes or CVD.
   Design and Setting: At an academic medical center, we compared MetS (n = 43) vs. control subjects (n = 33). Fasting blood was collected for monocyte isolation and assay of OS biomarkers.
   Main Outcome: Monocyte nicotinamide adenine dinucleotide phosphate oxidase activity (p22 phox and p47), superoxide anion release, oxidized-low-density lipoprotein (Ox-LDL), nitrotyrosine, and nuclear factor erythroid 2-related factor were measured.
   Results: There was significantly increased release of superoxide from the monocytes (basal and after activation) of MetS compared with controls adjusted for body mass index. Body mass index-adjusted plasma levels of Ox-LDL and nitrotyrosine were significantly increased in MetS. There was a linear trend between biomarkers of oxidative stress and increasing number of features of MetS. Also, there was a significant increase in nicotinamide adenine dinucleotide phosphate oxidase membrane expression of p22 phox and p47 phox in MetS. The major cellular antioxidant defense, nuclear factor erythroid 2-related factor was significantly decreased. There were significant correlations between homeostasis model assessment insulin resistance index and both Ox-LDL and nitrotyrosine and superoxide and Ox-LDL.
   Conclusions: Collectively, nascent MetS is associated with increased OS as evidenced by both circulating and cellular biomarkers, and this could contribute to the risk for both diabetes and CVD. (J Clin Endocrinol Metab 97: E1844-E1850, 2012)
C1 [Jialal, Ishwarlal] Univ Calif Davis, Med Ctr, Lab Atherosclerosis & Metab Res, Dept Pathol & Lab Med, Sacramento, CA 95817 USA.
   [Jialal, Ishwarlal] Vet Affairs Med Ctr, Mather, CA 95655 USA.
   [Devaraj, Sridevi; Chen, Xinpu] Texas Childrens Hosp, Dept Pathol, Houston, TX 77030 USA.
   Baylor Coll Med, Houston, TX 77030 USA.
   [Adams-Huet, Beverley] Univ Texas SW Med Ctr Dallas, Dept Biostat, Dallas, TX 75390 USA.
C3 University of California System; University of California Davis; US
   Department of Veterans Affairs; Veterans Health Administration (VHA);
   Baylor College of Medicine; Baylor College Medical Hospital; Baylor
   College of Medicine; University of Texas System; University of Texas
   Southwestern Medical Center Dallas
RP Jialal, I (corresponding author), Univ Calif Davis, Med Ctr, Lab Atherosclerosis & Metab Res, Dept Pathol & Lab Med, 4635 2nd Ave,Res 1 Bldg,Room 3000, Sacramento, CA 95817 USA.
EM ijialal@ucdavis.edu
RI Jialal, Ishwarlal/AAG-6218-2019; KAUR, HARMEET/C-7765-2012
FU American Diabetes Association
FX This work was supported by a grant from the American Diabetes
   Association (to I. J.).
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NR 38
TC 80
Z9 85
U1 0
U2 4
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0021-972X
EI 1945-7197
J9 J CLIN ENDOCR METAB
JI J. Clin. Endocrinol. Metab.
PD OCT 1
PY 2012
VL 97
IS 10
BP E1844
EP E1850
DI 10.1210/jc.2012-2498
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 018MH
UT WOS:000309664400003
PM 22872691
OA Bronze
DA 2025-06-11
ER

PT J
AU Sandstedt, M
   Bergfeldt, L
   Sandstedt, J
   Lundqvist, A
   Fryk, E
   Jansson, PA
   Bergström, G
   Hultén, LM
AF Sandstedt, Mikael
   Bergfeldt, Lennart
   Sandstedt, Joakim
   Lundqvist, Annika
   Fryk, Emanuel
   Jansson, Per-Anders
   Bergstrom, Goran
   Hulten, Lillemor Mattsson
TI Wide QRS-T angles are associated with markers of increased inflammatory
   activity independently of hypertension and diabetes
SO ANNALS OF NONINVASIVE ELECTROCARDIOLOGY
LA English
DT Article
DE cytokines; inflammation; QRS-T angles; sudden cardiac death;
   vectorcardiography; white blood cells
ID SUDDEN CARDIAC DEATH; C-REACTIVE PROTEIN; HEART-FAILURE;
   MYOCARDIAL-INFARCTION; ESTIMATING EQUATION; MYOCYTES; RISK;
   OVEREXPRESSION; PREDICTORS; CELLS
AB Background Wide QRS-T angles and inflammatory activity are markers of future cardiovascular events including sudden cardiac death (SCD). The association between wide QRS-T angles and inflammatory activation is however not fully understood. Methods 1,094 study participants of both sexes, 50-64 years old, were included from a randomly selected population-based cohort as a part of the Swedish CArdioPulmonary bioImage Study (SCAPIS) pilot study. Serum samples were analyzed for markers of inflammation, cardiac wall stress/injury, and the metabolic syndrome. Wide QRS-T angles were defined using Frank vectorcardiography. Variables were analyzed through unsupervised principal component analysis (PCA) as well as Orthogonal Projections to Latent Structures (OPLS) modeling. In addition, a subset of study participants was analyzed in a post hoc matched group design. Results Wide QRS-T angles correlated positively with markers of inflammation, cardiac wall stress/injury, the metabolic syndrome, and male sex in both PCA and OPLS models. In the matched post hoc analysis, participants with wide QRS-T angles had significantly higher counts of white blood cells (WBC) and neutrophils in comparison with matched controls. WBC as well as the number of neutrophils, monocytes, basophils, eosinophils and levels of C-reactive protein, IL-1, IL-4, IL-6, TNF-alpha, and NT-pro-BNP were also significantly higher in comparison with healthy controls. Conclusions Markers of inflammatory activation and cardiac injury/wall stress were significantly higher in the presence of wide QRS-T angles. These results corroborate an association between abnormal electrophysiological function and inflammatory activation and may have implications for the prediction of SCD.
C1 [Sandstedt, Mikael; Sandstedt, Joakim; Hulten, Lillemor Mattsson] Sahlgrens Univ Hosp, Dept Clin Chem, Reg Vastra Gotaland, Gothenburg, Sweden.
   [Sandstedt, Mikael; Sandstedt, Joakim] Univ Gothenburg, Sahlgrenska Acad, Inst Biomed, Dept Lab Med, Bruna Straket 16, S-41345 Gothenburg, Sweden.
   [Bergfeldt, Lennart] Sahlgrens Univ Hosp, Dept Cardiol, Reg Vastra Gotaland, Gothenburg, Sweden.
   [Bergfeldt, Lennart; Lundqvist, Annika; Fryk, Emanuel; Jansson, Per-Anders; Bergstrom, Goran; Hulten, Lillemor Mattsson] Univ Gothenburg, Sahlgrenska Acad, Inst Med, Dept Mol & Clin Med, Gothenburg, Sweden.
   [Jansson, Per-Anders] Sahlgrens Univ Hosp, Gothia Forum, Reg Vastra Gotaland, Gothenburg, Sweden.
C3 Sahlgrenska University Hospital; University of Gothenburg; Sahlgrenska
   University Hospital; University of Gothenburg; Sahlgrenska University
   Hospital
RP Sandstedt, M (corresponding author), Sahlgrens Univ Hosp, Dept Clin Chem, Reg Vastra Gotaland, Gothenburg, Sweden.; Sandstedt, M (corresponding author), Univ Gothenburg, Sahlgrenska Acad, Inst Biomed, Dept Lab Med, Bruna Straket 16, S-41345 Gothenburg, Sweden.
EM mikael.sandstedt@gu.se
RI Sandstedt, Mikael/GRO-7230-2022
OI Bergstrom, Goran/0000-0003-4289-5722
FU Hjart-Lungfonden [20130314, 20190214]; VINNOVA; Knut och Alice
   Wallenbergs Stiftelse; Swedish government [ALFGBG-722431, ALFGBG-74560,
   ALFGBG-813211]; Vetenskapsradet
FX Hjart-Lungfonden, Grant/Award Number: 20130314 and 20190214; VINNOVA;
   Knut och Alice Wallenbergs Stiftelse; Swedish state under the agreement
   between the Swedish government and the county councils, the
   ALF-agreement, Grant/Award Number: ALFGBG-722431, ALFGBG-74560 and
   ALFGBG-813211; Vetenskapsradet
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NR 38
TC 5
Z9 5
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1082-720X
EI 1542-474X
J9 ANN NONINVAS ELECTRO
JI Ann. Noninvasive Electrocardiol.
PD NOV
PY 2020
VL 25
IS 6
AR e12781
DI 10.1111/anec.12781
EA JUL 2020
PG 14
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA PA5DZ
UT WOS:000546680100001
PM 32638456
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Fernandes, IA
   Sales, ARK
   Rocha, NG
   Silva, BM
   Vianna, LC
   da Nóbrega, ACL
AF Fernandes, Igor A.
   Sales, Allan R. K.
   Rocha, Natalia G.
   Silva, Bruno M.
   Vianna, Lauro C.
   da Nobrega, Antonio C. L.
TI Preserved flow-mediated dilation but delayed time-to-peak diameter in
   individuals with metabolic syndrome
SO CLINICAL PHYSIOLOGY AND FUNCTIONAL IMAGING
LA English
DT Article
DE doppler; endothelial function; hyperaemia; shear stress; vascular
   reactivity
ID INCIDENT CARDIOVASCULAR EVENTS; ENDOTHELIAL FUNCTION; BRACHIAL-ARTERY;
   SHEAR-STRESS; DYSFUNCTION; RISK; ATHEROSCLEROSIS; DILATATION; HUMANS;
   POPULATION
AB Introduction: Inconsistent evidences of the metabolic syndrome (MetS) impact on vascular reactivity raise questions on flow-mediated dilation (FMD) discriminatory power for disturbances induced by this clustering of risk factors. Previous reports, however, suggest that covariates such as the follow-up of the artery diameter changes, the arterial size and shear stress affect FMD responses and consequently its discriminatory power for distinctive clinical profiles.
   Objective: To determine the impact of MetS on traditional, arterial size-and shear-rate-adjusted FMD, the follow-up-derived time-to-peak diameter (TP), as well as their power for discriminating subjects with this clustering of risk factors from a sample of healthy individuals.
   Methods: Twenty-one MetS and ten healthy subjects underwent an assessment of endothelial function via FMD.
   Results: Traditional and allometrically scaled FMD did not differ between groups (P>0.05) as well as the approach in which the covariate was the peak diameter shear rate. In the existence of MetS, TP was longer (67.7 +/- 16.4 s versus healthy 42.1 +/- 16.3 s, P = 0.001). ROC curve analysis indicated that TP (AUC = 0.871 [95% CI, 0.718-1.000]) had greater power of discrimination for MetS than FMD approaches. In addition, TP presented a moderate and significant association with sE-selectin (r = 0.458, P = 0.048).
   Conclusion: Time-to-peak diameter (TP) rather than FMD distinguished MetS from a healthy profile. Therefore, at least in subjects with MetS, TP may provide insights into the impact of this clustering of risk factors on the vascular phenotype.
C1 [Fernandes, Igor A.; Sales, Allan R. K.; Rocha, Natalia G.; Vianna, Lauro C.; da Nobrega, Antonio C. L.] Univ Fed Fluminense, Lab Exercise Sci, Dept Physiol & Pharmacol, BR-24210130 Niteroi, RJ, Brazil.
   [Silva, Bruno M.] Univ Fed Sao Paulo, Exercise Physiol Sect, Dept Physiol, Sao Paulo, Brazil.
C3 Universidade Federal Fluminense; Universidade Federal de Sao Paulo
   (UNIFESP)
RP da Nóbrega, ACL (corresponding author), Univ Fed Fluminense, Lab Exercise Sci, Dept Physiol & Pharmacol, Rua Prof Hernani Pires de Melo,106,Sala 101, BR-24210130 Niteroi, RJ, Brazil.
EM anobrega@id.uff.br
RI da Nobrega, Antonio/O-5107-2019; Sales, Allan/ABA-8691-2021; Vianna,
   Lauro/A-8188-2008; Silva, Bruno/F-7781-2010; Fernandes, Igor
   Alexandre/G-9589-2012; Rocha, Natalia Galito/AAN-7903-2020
OI Vianna, Lauro/0000-0002-5747-0295; Silva, Bruno/0000-0003-0473-3706;
   Fernandes, Igor Alexandre/0000-0003-3873-2656; Fernandes, Igor
   Alexandre/0000-0002-0206-6316; Rocha, Natalia Galito/0000-0002-1990-9834
FU Coordination for the Improvement of Higher Education Personnel (CAPES);
   Brazilian National Council for Scientific and Technological Development
   - CNPq; Foundation for Research Support of the State of Rio de Janeiro
   (FAPERJ); Brazilian Financing Agency of Studies and Projects (FINEP)
FX This study was supported by the Coordination for the Improvement of
   Higher Education Personnel (CAPES), Brazilian National Council for
   Scientific and Technological Development - CNPq, Foundation for Research
   Support of the State of Rio de Janeiro (FAPERJ) and the Brazilian
   Financing Agency of Studies and Projects (FINEP).
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NR 27
TC 25
Z9 28
U1 0
U2 7
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1475-0961
EI 1475-097X
J9 CLIN PHYSIOL FUNCT I
JI Clin. Physiol. Funct. Imaging
PD JUL
PY 2014
VL 34
IS 4
BP 270
EP 276
DI 10.1111/cpf.12092
PG 7
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA AN4PH
UT WOS:000340569600004
PM 24119214
DA 2025-06-11
ER

PT J
AU Schumacher, L
   Abbott, LC
AF Schumacher, Lauren
   Abbott, Louise C.
TI Effects of methyl mercury exposure on pancreatic beta cell development
   and function
SO JOURNAL OF APPLIED TOXICOLOGY
LA English
DT Review
DE Methyl mercury; pancreas; oxidative stress; pancreatic beta cells; type
   2 diabetes; metabolic syndrome; insulin resistance; antioxidants
ID ENDOPLASMIC-RETICULUM STRESS; PERSISTENT ORGANIC POLLUTANTS; CHRONIC
   OXIDATIVE STRESS; METABOLIC SYNDROME; GLUCOSE TOXICITY; GENE-EXPRESSION;
   HEAVY-METALS; VEGF-A; METHYLMERCURY; CHLORIDE
AB Methyl mercury is an environmental contaminant of worldwide concern. Since the discovery of methyl mercury exposure due to eating contaminated fish as the underlying cause of the Minamata disaster, the scientific community has known about the sensitivity of the developing central nervous system to mercury toxicity. Warnings are given to pregnant women and young children to limit consumption of foods containing methyl mercury to protect the embryonic, fetal and postnatally developing central nervous system. However, evidence also suggests that exposure to methyl mercury or various forms of inorganic mercury may also affect development and function of other organs. Numerous reports indicate a worldwide increase in diabetes, particularly type 2 diabetes. Quite recently, methyl mercury has been shown to have adverse effects on pancreatic beta () cell development and function, resulting in insulin resistance and hyperglycemia and may even lead to the development of diabetes. This review discusses possible mechanisms by which methyl mercury exposure may adversely affect pancreatic cell development and function, and the role that methyl mercury exposure may have in the reported worldwide increase in diabetes, particularly type 2 diabetes. While additional information is needed regarding associations between mercury exposure and specific mechanisms of the pathogenesis of diabetes in the human population, methyl mercury's adverse effects on the body's natural sources of antioxidants suggest that one possible therapeutic strategy could involve supplementation with antioxidants. Thus, it is important that additional investigation be undertaken into the role of methyl mercury exposure and reduced pancreatic cell function. Copyright (c) 2016 John Wiley & Sons, Ltd.
C1 [Schumacher, Lauren; Abbott, Louise C.] Texas A&M Univ, Coll Vet Med, Dept Vet Integrat Biosci, 4458 TAMU, College Stn, TX 77843 USA.
C3 Texas A&M University System; Texas A&M University College Station
RP Abbott, LC (corresponding author), Texas A&M Univ, Coll Vet Med, Dept Vet Integrat Biosci, 4458 TAMU, College Stn, TX 77843 USA.
EM labbott@cvm.tamu.edu
RI Abbott, Louise/AAC-4392-2022
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NR 117
TC 31
Z9 34
U1 4
U2 41
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0260-437X
EI 1099-1263
J9 J APPL TOXICOL
JI J. Appl. Toxicol.
PD JAN
PY 2017
VL 37
IS 1
BP 4
EP 12
DI 10.1002/jat.3381
PG 9
WC Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Toxicology
GA EC7DF
UT WOS:000388295300001
PM 27594070
DA 2025-06-11
ER

PT J
AU Kim, HJ
   Norton, CE
   Zawieja, SD
   Castorena-Gonzalez, JA
   Davis, MJ
AF Kim, Hae Jin
   Norton, Charles E.
   Zawieja, Scott D.
   Castorena-Gonzalez, Jorge A.
   Davis, Michael J.
TI Acute Metabolic Stress Induces Lymphatic Dysfunction Through
   KATP Channel Activation
SO FUNCTION
LA English
DT Article
DE contractile dysfunction; lymph pump; metabolic syndrome; reactive oxygen
   species; action potential; mitochondrial electron transport chain
ID OXYGEN-FREE RADICALS; REACTIVE OXYGEN; CA2+ CHANNEL; POTASSIUM CHANNELS;
   5-HYDROXYDECANOATE; CONTRACTILITY; MITOCHONDRIA; MECHANISMS; HEART; FLOW
AB Lymphatic dysfunction is an underlying component of multiple metabolic diseases, including diabetes, obesity, and metabolic syndrome. We investigated the roles of KATP channels in lymphatic contractile dysfunction in response to acute metabolic stress induced by inhibition of the mitochondrial electron transport chain. Ex vivo popliteal lymphatic vessels from mice were exposed to the electron transport chain inhibitors antimycin A and rotenone, or the oxidative phosphorylation inhibitor/protonophore, CCCP. Each inhibitor led to a significant reduction in the frequency of spontaneous lymphatic contractions and calculated pump flow, without a significant change in contraction amplitude. Contraction frequency was restored by the K-ATP channel inhibitor, glibenclamide. Lymphatic vessels from mice with global Kir6.1 deficiency or expressing a smooth muscle-specific dominant negative Kir6.1 channel were resistant to inhibition. Antimycin A inhibited the spontaneous action potentials generated in lymphatic muscle and this effect was reversed by glibenclamide, confirming the role of KATP channels. Antimycin A, but not rotenone or CCCP, increased dihydrorhodamine fluorescence in lymphatic muscle, indicating ROS production. Pretreatment with tiron or catalase prevented the effect of antimycin A on wild-type lymphatic vessels, consistent with its action being mediated by ROS. Our results support the conclusion that KATP channels in lymphatic muscle can be directly activated by reduced mitochondrial ATP production or ROS generation, consequent to acute metabolic stress, leading to contractile dysfunction through inhibition of the ionic pacemaker controlling spontaneous lymphatic contractions. We propose that a similar activation of K-ATP channels contributes to lymphatic dysfunction in metabolic disease.
C1 [Kim, Hae Jin; Norton, Charles E.; Zawieja, Scott D.; Davis, Michael J.] Univ Missouri, Dept Med Pharmacol & Physiol, Columbia, MO 65212 USA.
   [Castorena-Gonzalez, Jorge A.] Tulane Univ, Sch Med, Dept Pharmacol, New Orleans, LA 70112 USA.
C3 University of Missouri System; University of Missouri Columbia; Tulane
   University
RP Davis, MJ (corresponding author), Univ Missouri, Dept Med Pharmacol & Physiol, Columbia, MO 65212 USA.
EM davismj@health.missouri.edu
RI Norton, Charles/ABF-5088-2022
FU National Institutes of Health [R01HL-141107, HL-122578, R01 HL-168568,
   R00 HL-143198]; National Research Foundation of Korea
   [NRF-2020R1A6A3A03037151]
FX This research was supported by the National Institutes of Health grants
   R01HL-141107 and HL-122578 to M.J.D., R01 HL-168568 to J.A.C.-G., and
   R00 HL-143198 to S.D.Z.; H.J.K. was supported in part by the National
   Research Foundation of Korea grant NRF-2020R1A6A3A03037151.
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NR 80
TC 1
Z9 1
U1 0
U2 1
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
EI 2633-8823
J9 FUNCTION
JI Function
PD SEP 10
PY 2024
VL 5
IS 5
AR zqae033
DI 10.1093/function/zqae033
PG 16
WC Cell Biology; Physiology
WE Emerging Sources Citation Index (ESCI)
SC Cell Biology; Physiology
GA F4L2H
UT WOS:001309542500007
PM 39075985
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Zeid, AAA
   Raafat, IR
   Ahmed, AG
AF Abo Zeid, Abeer A.
   Rowida Raafat, Ibrahim
   Ahmed, Abeer G.
TI Berberine alleviates monosodium glutamate induced postnatal metabolic
   disorders associated vascular endothelial dysfunction in newborn rats:
   possible role of matrix metalloproteinase-1
SO ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
LA English
DT Article
DE Monosodium glutamate; metabolic syndrome; endothelin-1; matrix
   metalloproteinase; vascular disorder; berberine
ID LOW-DENSITY-LIPOPROTEIN; SMOOTH-MUSCLE-CELLS; INSULIN-RESISTANCE;
   OXIDATIVE STRESS; PROTEIN-KINASE; DIET; EXPRESSION; OBESITY;
   ANTIOXIDANT; MODULATION
AB Excessive food additives Monosodium glutamate (MSG) results in metabolic disorders with increased Cardiovascular diseases CVD. We aimed to emphasise berberine (BBR) effect on MSG induced metabolic syndrome (MetS) and its associated endothelial dysfunction. Newborn rats were divided into control group, MSG group (4 mg/g) each other day for the first 14 days of life and MSG + BBR group that was given MSG then BBR in dose 150 mg/kg/day for 6 weeks. Body weight, food intake, systolic blood pressure, biochemical metabolic and oxidative stress markers were evaluated. Aortic tissue homogenate Endothelin -1 (ET-1) and matrix metalloproteinase -1 (MMP-1) assessment, in addition to histological and EM examination were done. Newborn rats MSG exposure results in typical adult life MetS and oxidative stress with significant increase in ET-1 and MMP-1with aortic vasculopathy. BBR significantly improved all the disturbed parameters; suppress increased body weight (BW), food intake (FI) and partly improved the aortic vasculopathy lesions, holding a promise for BBR as a defending agent against MSG metabolic and vascular disorders.HIGH LIGHT MSG MSG is frequently consumed as a flavour enhancer especially between children and adolescent Excessive utilisation MSG is associated MS with vascular endothelial dysfunction MMP-1 may be involved in atherosclerotic plaque formation BBR has beneficial outcome for metabolic disorders induced by MSG among newly born rats BBR has a role in management vascular inflammation and remodelling
C1 [Abo Zeid, Abeer A.] Tanta Univ, Dept Physiol, Fac Med, Tanta, Egypt.
   [Rowida Raafat, Ibrahim] Tanta Univ, Fac Med, Dept Med Biochem & Mol Biol, El Geesh St, Tanta 31511, Egypt.
   [Ahmed, Abeer G.] Alexandria Univ, Fac Med, Dept Anat, Alexandria, Egypt.
C3 Egyptian Knowledge Bank (EKB); Tanta University; Egyptian Knowledge Bank
   (EKB); Tanta University; Egyptian Knowledge Bank (EKB); Alexandria
   University
RP Raafat, IR (corresponding author), Tanta Univ, Fac Med, Dept Med Biochem & Mol Biol, El Geesh St, Tanta 31511, Egypt.
EM rowaida.yousef@med.tanta.edu.eg
RI Ibrahim, Rowida/AAD-4234-2021
OI Raafat, Rowida/0000-0002-6500-8156
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NR 65
TC 5
Z9 5
U1 0
U2 6
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1381-3455
EI 1744-4160
J9 ARCH PHYSIOL BIOCHEM
JI Arch. Physiol. Biochem.
PD MAY 4
PY 2022
VL 128
IS 3
BP 818
EP 829
DI 10.1080/13813455.2020.1729815
EA FEB 2020
PG 12
WC Biochemistry & Molecular Biology; Biophysics; Endocrinology &
   Metabolism; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Endocrinology &
   Metabolism; Physiology
GA 1U8AJ
UT WOS:000514890600001
PM 32072839
DA 2025-06-11
ER

EF﻿FN Clarivate Analytics Web of Science
VR 1.0
PT J
AU Shukla, P
   Mukherjee, S
AF Shukla, Pallavi
   Mukherjee, Srabani
TI Mitochondrial dysfunction: An emerging link in the pathophysiology of
   polycystic ovary syndrome
SO MITOCHONDRION
LA English
DT Review
DE Polycystic Ovary syndrome; Mitochondrion; Mitochondrial dysfunction;
   Oxidative stress; Subfertility
ID ENDOPLASMIC-RETICULUM STRESS; NUCLEAR RESPIRATORY FACTORS; TRANSFER-RNA
   GENES; DNA COPY NUMBER; INSULIN-RESISTANCE; OXIDATIVE STRESS;
   SKELETAL-MUSCLE; METABOLIC SYNDROME; MOUSE MODEL; ESSENTIAL-HYPERTENSION
AB Polycystic ovary syndrome (PCOS) is a common endocrine disorder characterized by irregular menstrual cycles, hyperandrogenism and subfertility. Due to its complex manifestation, the pathogenic mechanism of PCOS is not well defined. Cumulative effect of altered genetic and epigenetic factors along with environmental factors may play a role in the manifestation of PCOS leading to systemic malfunction. With failure of genome-wide association study (GWAS) and other studies performed on nuclear genome to provide any clue for precise mechanism of PCOS pathogenesis, attention has been diverted to mitochondria. Mitochondrion plays an important role in cellular metabolic functions and is linked to Insulin Resistance (IR). Recently, increasing reports suggest that mitochondrial dysfunction may be a contributing factor in the pathogenesis of PCOS. Hence, in this review, we have discussed mitochondrial biology in brief and emphasizes on genetic and epigenetic aspects of mitochondrial dysfunction studied in PCOS women and PCOS-like animal models. We also highlight underlying mechanism behind mitochondrial dysfunction contributing to PCOS and its related complications such as obesity, diabetes, cardiovascular diseases, metabolic syndrome, non-alcoholic fatty liver disease (NAFLD) and cancer. Furthermore, contrasting remarks against involvement of mitochondrial dysfunction in PCOS pathophysiology have also been presented. This review enhances our understanding in relation to mitochondrial dysfunction in the etiology of PCOS and stimulates further research to explore a clear link between mitochondrial dysfunction and PCOS pathogenesis and progression. Understanding pathogenic mechanisms underlying PCOS will open new windows to develop promising therapeutic strategies against PCOS.
C1 [Shukla, Pallavi; Mukherjee, Srabani] ICMR Natl Inst Res Reprod Hlth NIRRH, Dept Mol Endocrinol, Mumbai, Maharashtra, India.
C3 Indian Council of Medical Research (ICMR); ICMR - National Institute for
   Research in Reproductive & Child Health (NIRRCH)
RP Shukla, P (corresponding author), ICMR Natl Inst Res Reprod Hlth NIRRH, Dept Mol Endocrinol, Mumbai, Maharashtra, India.
EM shuklap@nirrh.res.in
RI Mukherjee, Srabani/AGZ-9170-2022
OI Shukla, Pallavi/0000-0001-7979-6651
FU National Institute for Research in Reproductive Health and Indian
   Council of Medical Research (ICMR) [REV/797/09-2019]
FX The authors acknowledge the National Institute for Research in
   Reproductive Health and Indian Council of Medical Research (ICMR) for
   providing necessary support (REV/797/09-2019).
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NR 153
TC 51
Z9 56
U1 0
U2 16
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1567-7249
EI 1872-8278
J9 MITOCHONDRION
JI Mitochondrion
PD MAY
PY 2020
VL 52
BP 24
EP 39
DI 10.1016/j.mito.2020.02.006
PG 16
WC Cell Biology; Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Genetics & Heredity
GA LJ5UC
UT WOS:000530229300004
PM 32081727
DA 2025-06-11
ER

PT J
AU El-Shinnawi, U
   Soory, M
AF El-Shinnawi, U.
   Soory, M.
TI Actions of Adjunctive Nutritional Antioxidants in Periodontitis and
   Prevalent Systemic Inflammatory Diseases
SO ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS
LA English
DT Article
DE Chronic inflammatory diseases; mechanisms of action; metabolic syndrome;
   nutritional antioxidants; oxidative stress; periodontitis; therapeutic
   adjuncts
ID VIRGIN OLIVE OIL; IMPROVES ENDOTHELIAL FUNCTION; C-REACTIVE PROTEIN;
   OXIDATIVE STRESS; MEDITERRANEAN DIET; BLOOD-PRESSURE; DOCOSAHEXAENOIC
   ACID; VITAMIN-D; ANTIINFLAMMATORY ACTIVITY; CARDIOVASCULAR-DISEASE
AB Common risk markers for periodontitis and prevalent systemic comorbidities indicate similarities in their progression and molecular mechanisms involved. Resultant pro-oxidant disease profiles provide scope for attenuating their pathogeneses with appropriate adjunctive antioxidants. Levels of oxidative stress markers 8-hydroxy-deoxguanosine (8-HOdG) and malondialdehyde (MDA) are significantly higher in periodontitis and other chronic inflammatory conditions. There is a clear link between periodontitis and diseases associated with significant systemic inflammatory loading, such as metabolic syndrome. Micro-and macro-nutrients have proven to be effective in curbing molecular mechanisms that generate reactive oxygen and nitrogen species. A Mediterranean diet rich in fruits, vegetables, legumes, whole grain, nuts, fish, olive oil and red wine in moderation, could be attributed to the lower occurrence of cardiovascular disease, insulin resistance and other inflammatory diseases in this region. A significant number of naturally occurring flavonoids have been identified in these products. Flavonoids comprising flavonols, flavones and isoflavones are potent free radical scavengers, effective in inhibiting lipid peroxidation, with anti-atherosclerotic and antihypertensive effects. The phenolic compound oleocanthal isolated in virgin olive oil has similar anti-inflammatory actions to that of ibuprofen. The anti-atherogenic effects of MUFA and PUFA in nuts, enhance endothelial function by reducing total cholesterol, oxidized LDL, hs-CRP, sVCAM-1 levels, lipids, lipoproteins and inflammatory markers. Epigenetics influenced by environmental factors and interactions between genes and nutrients, are important considerations in influencing these effects. Using antioxidants as therapeutic adjuncts could enhance the antioxidant capacity of an inherent glutathione system and overcome oxidative effects, thereby mitigating therapeutic side-effects.
C1 [El-Shinnawi, U.] Mansoura Univ, Fac Dent, Periodontol & Oral Med, Mansoura, Egypt.
   [Soory, M.] Kings Coll London, Inst Dent, Periodontol, London SE5 9RW, England.
C3 Egyptian Knowledge Bank (EKB); Mansoura University; University of
   London; King's College London
RP Soory, M (corresponding author), Kings Coll London, Inst Dent, Periodontol, Denmark Hill, London SE5 9RW, England.
EM mena.soory@kcl.ac.uk
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NR 134
TC 9
Z9 9
U1 1
U2 10
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1871-5303
EI 2212-3873
J9 ENDOCR METAB IMMUNE
JI Endocr. Metab. Immune Disord.-Drug Targets
PY 2015
VL 15
IS 4
BP 261
EP 276
DI 10.2174/1871530315666150429125041
PG 16
WC Endocrinology & Metabolism; Immunology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Immunology; Pharmacology & Pharmacy
GA CY8NW
UT WOS:000366666500002
PM 25922082
DA 2025-06-11
ER

PT J
AU Kong, ASY
   Lai, KS
   Hee, CW
   Loh, JY
   Lim, SHE
   Sathiya, M
AF Kong, Amanda Shen-Yee
   Lai, Kok Song
   Hee, Cheng-Wan
   Loh, Jiun Yan
   Lim, Swee Hua Erin
   Sathiya, Maran
TI Oxidative Stress Parameters as Biomarkers of Cardiovascular Disease
   towards the Development and Progression
SO ANTIOXIDANTS
LA English
DT Review
DE reactive oxygen species; oxidative stress; oxidant; cardiovascular;
   biomarkers
ID SPIN-RESONANCE SPECTROSCOPY; ASYMMETRIC DIMETHYLARGININE; METABOLIC
   SYNDROME; INFLAMMATION; MYELOPEROXIDASE; DYSFUNCTION; CHILDREN; HEART;
   DAMAGE; ANTIOXIDANTS
AB Cardiovascular disease (CVD) remains the leading cause of death globally, with unhealthy lifestyles today greatly increasing the risk. Over the decades, scientific investigation has been carried out on reactive oxygen species (ROS) and their resultant oxidative stress based on their changes made on biological targets such as lipids, proteins, and DNA. Since the existing clinical studies with antioxidants failed to provide relevant findings on CVD prediction, the focus has shifted towards recognition of oxidised targets as biomarkers to predict prognosis and response to accurate treatment. The identification of redox markers could help clinicians in providing risk stratification for CVD events beyond the traditional prognostic and diagnostic targets. This review will focus on how oxidant-related parameters can be applied as biomarkers for CVD based on recent clinical evidence.
C1 [Kong, Amanda Shen-Yee; Sathiya, Maran] Monash Univ Malaysia, Sch Pharm, Jalan Lagoon Selatan, Bandar Sunway 47500, Subang Jaya, Malaysia.
   [Lai, Kok Song; Lim, Swee Hua Erin] Abu Dhabi Womens Coll, Higher Coll Technol, Hlth Sci Div, Abu Dhabi 41012, U Arab Emirates.
   [Hee, Cheng-Wan] INTI Int Univ, Fac Hlth & Life Sci, Putra Nilai 71800, Nilai, Malaysia.
   [Loh, Jiun Yan] UCSI Univ, Ctr Res Adv Aquaculture CORAA, Kuala Lumpur 56000, Malaysia.
C3 Monash University; Monash University Malaysia; Higher Colleges of
   Technology - United Arab Emirates; INTI International University; UCSI
   University
RP Sathiya, M (corresponding author), Monash Univ Malaysia, Sch Pharm, Jalan Lagoon Selatan, Bandar Sunway 47500, Subang Jaya, Malaysia.
EM kong.amanda0811@gmail.com; lkoksong@hct.ac.ae;
   wanhee.cheng@newinti.edu.my; lohjy@ucsiuniversity.edu.my;
   lerin@hct.ac.ae; sathiya.maran@monash.edu
RI Loh, Jiun/AAI-9818-2020; Lai, Kok/AAR-8772-2020; Kong, Amanda
   Shen-Yee/GOV-5527-2022
OI Kong, Amanda Shen-Yee/0000-0002-6967-6928; Loh, Jiun
   Yan/0000-0003-2857-9184; Maran, Sathiya/0000-0001-5617-901X
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NR 79
TC 21
Z9 22
U1 2
U2 15
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD JUN
PY 2022
VL 11
IS 6
AR 1175
DI 10.3390/antiox11061175
PG 13
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA 2K1AN
UT WOS:000816076300001
PM 35740071
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Vo, T
   Hardy, DB
AF Vo, Thin
   Hardy, Daniel B.
TI Molecular mechanisms underlying the fetal programming of adult disease
SO JOURNAL OF CELL COMMUNICATION AND SIGNALING
LA English
DT Review
DE Fetal Programming; Epigenetics; microRNA; Posttranslational Histone
   Modifications; DNA Methylation; ER Stress; Nuclear Receptors
ID ENDOPLASMIC-RETICULUM STRESS; ACTIVATED-RECEPTOR-GAMMA; LOW-PROTEIN
   DIET; INTRAUTERINE GROWTH RESTRICTION; HEPATIC PHOSPHOENOLPYRUVATE
   CARBOXYKINASE; FOLIC-ACID SUPPLEMENTATION; SYSTOLIC BLOOD-PRESSURE;
   ISCHEMIC-HEART-DISEASE; ENZYME GENE-EXPRESSION; GLUCOCORTICOID-RECEPTOR
AB Adverse events in utero can be critical in determining quality of life and overall health. It is estimated that up to 50 % of metabolic syndrome diseases can be linked to an adverse fetal environment. However, the mechanisms linking impaired fetal development to these adult diseases remain elusive. This review uncovers some of the molecular mechanisms underlying how normal physiology may be impaired in fetal and postnatal life due to maternal insults in pregnancy. By understanding the mechanisms, which include epigenetic, transcriptional, endoplasmic reticulum (ER) stress, and reactive oxygen species (ROS), we also highlight how intervention in fetal and neonatal life may be able to prevent these diseases long-term.
C1 [Vo, Thin; Hardy, Daniel B.] Univ Western Ontario, Dept Physiol & Pharmacol, London, ON N6A 5C1, Canada.
   [Vo, Thin; Hardy, Daniel B.] Univ Western Ontario, Dept Obstet & Gynecol, London, ON N6A 5C1, Canada.
   [Vo, Thin; Hardy, Daniel B.] Childrens Hlth Res Inst, London, ON N6C 2V5, Canada.
   [Vo, Thin; Hardy, Daniel B.] Lawson Hlth Res Inst, London, ON N6A 4V2, Canada.
C3 Western University (University of Western Ontario); Western University
   (University of Western Ontario); Western University (University of
   Western Ontario); University Western Ontario Hospital
RP Hardy, DB (corresponding author), Univ Western Ontario, Dept Physiol & Pharmacol, London, ON N6A 5C1, Canada.
EM daniel.hardy@schulich.uwo.ca
RI Hardy, Daniel/GYU-8976-2022
OI Hardy, Daniel/0000-0001-5445-273X; Vo, Thin Xuan/0000-0002-2131-5701
FU CIHR Operating Grant; Natural Sciences and Engineering Research Council
   of Canada
FX Supported by: CIHR Operating Grant and Natural Sciences and Engineering
   Research Council of Canada
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NR 169
TC 36
Z9 48
U1 0
U2 5
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1873-9601
EI 1873-961X
J9 J CELL COMMUN SIGNAL
JI J. Cell Commun. Signal
PD AUG
PY 2012
VL 6
IS 3
BP 139
EP 153
DI 10.1007/s12079-012-0165-3
PG 15
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA V39ON
UT WOS:000209420400003
PM 22623025
OA Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Rizzo, M
   Kotur-Stevuljevic, J
   Berneis, K
   Spinas, G
   Rini, GB
   Jelic-Ivanovic, Z
   Spasojevic-Kalimanovska, V
   Vekic, J
AF Rizzo, Manfredi
   Kotur-Stevuljevic, Jelena
   Berneis, Kaspar
   Spinas, Giatgen
   Rini, Giovam Battista
   Jelic-Ivanovic, Zorana
   Spasojevic-Kalimanovska, Vesna
   Vekic, Jelena
TI Atherogenic dyslipidemia and oxidative stress: a new look
SO TRANSLATIONAL RESEARCH
LA English
DT Review
ID LOW-DENSITY-LIPOPROTEIN; CORONARY-ARTERY-DISEASE; INTIMA-MEDIA
   THICKNESS; NITRIC-OXIDE SYNTHASE; LDL PARTICLE-SIZE; LIPID-PEROXIDATION;
   METABOLIC SYNDROME; HEART-DISEASE; OXIDIZED LDL; CLINICAL-SIGNIFICANCE
AB Although results from in vitro studies and clinical trials demonstrate strong associations between oxidative stress and cardiovascular risk, to date still no convincing data are available to suggest that treatment with antioxidants might reduce vascular events. Oxidative modifications of low-density lipoproteins (LDL) represent an early stage of atherosclerosis, and small, dense LDL are more susceptible to oxidation than larger, more buoyant particles. Oxidized LDL are independent predictors of subclinical and clinical atherosclerosis. Recent studies suggested that novel therapeutic strategies may take into account the removal of such particles from circulation. Future research is required to explore the potential synergistic impact of markers of oxidative stress and atherogenic dyslipidemia, particularly small dense LDL, on cardiovascular risk. (Translational Research 2009; 153:217-223)
C1 Univ Palermo, Dept Internal Med & Emerging Dis, I-90127 Palermo, Italy.
   Fac Pharm, Inst Med Biochem, Belgrade, Serbia.
   Univ Zurich Hosp, Div Endocrinol Diabet & Clin Nutr, CH-8091 Zurich, Switzerland.
C3 University of Palermo; University of Belgrade; University of Zurich;
   University Zurich Hospital
RP Rizzo, M (corresponding author), Univ Palermo, Dipartimento Med Clin & Patol Emergenti, Via Vespro 141, I-90127 Palermo, Italy.
EM mrizzo@unipa.it
RI RIZZO, MANFREDI/GZL-0551-2022
OI RIZZO, Manfredi/0000-0002-9549-8504; Vekic, Jelena/0000-0001-7445-0504
FU Ministry of Science and Environmental Protection, Republic of Serbia
   [145036B]
FX Jelena Kotur-Stevuljevic, Zorana Jelic-Ivanovic, Vesna
   Spasojevic-Kalimanovska, and Jelena Vekic are supported by a grant from
   the Ministry of Science and Environmental Protection, Republic of Serbia
   (Project No. 145036B).
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NR 93
TC 109
Z9 118
U1 2
U2 6
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1931-5244
EI 1878-1810
J9 TRANSL RES
JI Transl. Res.
PD MAY
PY 2009
VL 153
IS 5
BP 217
EP 223
DI 10.1016/j.trsl.2009.01.008
PG 7
WC Medical Laboratory Technology; Medicine, General & Internal; Medicine,
   Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology; General & Internal Medicine; Research &
   Experimental Medicine
GA 441GF
UT WOS:000265756600002
PM 19375682
DA 2025-06-11
ER

PT J
AU Kim, M
   Shin, D
AF Kim, Minyeong
   Shin, Dayeon
TI Effects of the Interaction Between Oxidative Balance Score and Polygenic
   Risk Scores on Incidence of Metabolic Syndrome in Middle-Aged Korean
   Adults
SO ANTIOXIDANTS
LA English
DT Article
DE metabolic syndrome; oxidative balance score; polygenic risk score
ID INSULIN-RESISTANCE; NATIONAL-HEALTH; STRESS STATUS; ASSOCIATION;
   POPULATION; PREVALENCE; VARIANTS; DISEASE; DIETARY; ATHEROSCLEROSIS
AB Oxidative stress is implicated in insulin resistance, obesity, and metabolic syndromes (MetSs). However, the interplay between oxidative stress and genetic predisposition during the development of MetS remains unclear. In this study, we aimed to investigate the effects of the interaction between oxidative balance score (OBS) and polygenic risk score (PRS) on the incidence of MetS in middle-aged Korean adults. We analyzed data from 25,879 participants aged >= 40 years from the Health Examinees Cohort of the Korean Genome and Epidemiology Study. The OBS was calculated using 11 antioxidant and five pro-oxidant factors. A genome-wide association study and clumping analysis identified 16 independent single-nucleotide polymorphisms associated with MetS that were used to calculate individual PRSs. Multivariable Cox proportional hazard models adjusted for confounding variables were used to assess the impact of OBS and PRS on the incidence of MetS. During a mean follow-up period of 4.3 years, we recorded 3153 cases of MetS. In both men and women, the group with the lowest OBS and a high PRS had a 1.50-fold (hazard ratio [HR] 1.50, 95% confidence interval [CI] 1.07-2.11) and 1.89-fold (HR 1.89, 95% CI 1.40-2.56) higher incidence, respectively, of MetS compared to those with the highest OBS and a low PRS. Among women with a high PRS, the HRs decreased significantly across OBS quintiles 1 through 5 (p for trend = 0.009). These findings suggest that managing the oxidative balance may be particularly crucial for individuals with a high genetic risk for MetS.
C1 [Kim, Minyeong; Shin, Dayeon] Inha Univ, Dept Food & Nutr, 100 Inha Ro, Incheon 22212, South Korea.
C3 Inha University
RP Shin, D (corresponding author), Inha Univ, Dept Food & Nutr, 100 Inha Ro, Incheon 22212, South Korea.
EM kmy000923@naver.com; dyshin@inha.ac.kr
OI Kim, Minyeong/0009-0000-4445-3827
FU National Research Foundation of Korea grant funded by the Korean
   Government (MSIT) [RS-2024-00340086]; National Research Foundation of
   Korea - Korean Government (MSIT)
FX This work was supported by a National Research Foundation of Korea grant
   funded by the Korean Government (MSIT) (RS-2024-00340086).
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NR 86
TC 0
Z9 0
U1 2
U2 2
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD DEC
PY 2024
VL 13
IS 12
AR 1556
DI 10.3390/antiox13121556
PG 21
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA Q4D6M
UT WOS:001384212200001
PM 39765884
OA gold
DA 2025-06-11
ER

PT J
AU Leclercq, IA
   Morais, ADS
   Schroyen, B
   Van Hul, N
   Geerts, A
AF Leclercq, Isabelle A.
   Morais, Alain Da Silva
   Schroyen, Ben
   Van Hul, Noml
   Geerts, Albert
TI Insulin resistance in hepatocytes and sinusoidal liver cells: Mechanisms
   and consequences
SO JOURNAL OF HEPATOLOGY
LA English
DT Review
ID HEPATIC STELLATE CELLS; GLYCATION END-PRODUCTS; NONALCOHOLIC FATTY
   LIVER; NECROSIS-FACTOR-ALPHA; TISSUE GROWTH-FACTOR; ADIPOSE-TISSUE;
   METABOLIC SYNDROME; OXIDATIVE STRESS; SIGNALING PATHWAYS;
   LIPID-METABOLISM
AB Hepatic insulin resistance is an important underlying cause of the metabolic syndrome that manifests itself in diseases such as diabetes type II, atherosclerosis or non-alcoholic fatty liver disease (NAFLD). In this paper, we summarize comprehensively the current state of knowledge pertaining to the molecular mechanisms that lead to insulin resistance in hepatocytes and sinusoidal liver cells.
   In hepatocytes, the insulin resistant state is brought about by at least one, but more likely by a combination, of the following pathological alterations: hyperglycaemia and hyperinsulinaemia, formation of advanced glycation end-products, increased free fatty acids and their metabolites, oxidative stress and altered profiles of adipocytokines. Insulin resistance in hepatocytes distorts directly glucose metabolism, especially the control over glucose output into the circulation and interferes with cell survival and proliferation, while hepatic fatty acid synthesis remains stimulated by compensatory hyperinsulinaemia, resulting in steatosis.
   Very few studies have addressed insulin resistance in sinusoidal liver cells. These cells are not simply bystanders and passive witnesses of the changes affecting the hepatocytes. They are target cells that will respond to the pathological alterations occurring in the insulin resistant state. They are also effector cells that may exacerbate insulin resistance in hepatocytes by increasing oxidative stress and by secreting cytokines such as TNF and IL-6. Moreover, activation of sinusoidal endothelial cells, Kupffer cells and stellate cells will lead to chemo-attraction of inflammatory cells. Finally, activation of stellate cells will set in motion a fibrogenic response that paves the way to cirrhosis. (c) 2007 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
C1 Catholic Univ Louvain, Fac Med, Gastrointestinal Lab, B-1200 Brussels, Belgium.
   Vrije Univ Brussel, Dept Cell Biol, Brussels, Belgium.
C3 Universite Catholique Louvain; Vrije Universiteit Brussel
RP Leclercq, IA (corresponding author), Catholic Univ Louvain, Fac Med, Gastrointestinal Lab, GAEN 53-79,Ave Mounier 53, B-1200 Brussels, Belgium.
EM isabelle.leclercq@uclouvain.be
RI Van Hul, Noemi/AAB-7985-2020; da Silva Morais, Alain/M-5574-2013
OI da Silva Morais, Alain/0000-0001-5057-0819; Van Hul,
   Noemi/0000-0003-1410-8808
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NR 124
TC 271
Z9 313
U1 2
U2 30
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0168-8278
EI 1600-0641
J9 J HEPATOL
JI J. Hepatol.
PD JUL
PY 2007
VL 47
IS 1
BP 142
EP 156
DI 10.1016/j.jhep.2007.04.002
PG 15
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 185JG
UT WOS:000247706700021
PM 17512085
OA Bronze
DA 2025-06-11
ER

PT J
AU Lee, WS
   Ham, W
   Kim, J
AF Lee, Wang-Soo
   Ham, Woojin
   Kim, Jaetaek
TI Roles of NAD(P)H:quinone Oxidoreductase 1 in Diverse Diseases
SO LIFE-BASEL
LA English
DT Article
DE NAD(P)H; quinone oxidoreductase 1; oxidative stress; human diseases
ID MEMBRANE REDOX SYSTEM; INDUCED DNA-DAMAGE; HIGH-FAT DIET; DT-DIAPHORASE;
   OXIDATIVE STRESS; NAD(P)H-QUINONE OXIDOREDUCTASE; QUINONE
   OXIDOREDUCTASE; BETA-LAPACHONE; PROTEASOMAL DEGRADATION;
   CRYSTAL-STRUCTURE
AB NAD(P)H:quinone oxidoreductase (NQO) is an antioxidant flavoprotein that catalyzes the reduction of highly reactive quinone metabolites by employing NAD(P)H as an electron donor. There are two NQO enzymes-NQO1 and NQO2-in mammalian systems. In particular, NQO1 exerts many biological activities, including antioxidant activities, anti-inflammatory effects, and interactions with tumor suppressors. Moreover, several recent studies have revealed the promising roles of NQO1 in protecting against cardiovascular damage and related diseases, such as dyslipidemia, atherosclerosis, insulin resistance, and metabolic syndrome. In this review, we discuss recent developments in the molecular regulation and biochemical properties of NQO1, and describe the potential beneficial roles of NQO1 in diseases associated with oxidative stress.
C1 [Lee, Wang-Soo] Chung Ang Univ, Div Cardiol, Dept Internal Med, Coll Med, Seoul 06974, South Korea.
   [Ham, Woojin; Kim, Jaetaek] Chung Ang Univ, Div Endocrinol & Metab, Dept Internal Med, Coll Med, Seoul 06974, South Korea.
C3 Chung Ang University; Chung Ang University Hospital; Chung Ang
   University; Chung Ang University Hospital
RP Lee, WS (corresponding author), Chung Ang Univ, Div Cardiol, Dept Internal Med, Coll Med, Seoul 06974, South Korea.; Kim, J (corresponding author), Chung Ang Univ, Div Endocrinol & Metab, Dept Internal Med, Coll Med, Seoul 06974, South Korea.
EM wslee1227@cau.ac.kr; dglyue5@cau.ac.kr; jtkim@cau.ac.kr
RI Lee, Wang-Soo/AAS-1477-2021
OI Lee, Wang-Soo/0000-0002-8264-0866
FU Chung-Ang University Research Scholarship Grants 2020; Basic Science
   Research Program through the National Research Foundation of Korea
   [2020R1A2C1009647]
FX This study was supported by Chung-Ang University Research Scholarship
   Grants 2020 to W.H., and by the Basic Science Research Program through
   the National Research Foundation of Korea to W.-S.L. (2020R1A2C1009647).
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NR 175
TC 32
Z9 33
U1 1
U2 18
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2075-1729
J9 LIFE-BASEL
JI Life-Basel
PD DEC
PY 2021
VL 11
IS 12
AR 1301
DI 10.3390/life11121301
PG 20
WC Biology; Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics; Microbiology
GA YA3SI
UT WOS:000738256800001
PM 34947831
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Mohamed, AI
   Erukainure, OL
   Salau, VF
   Islam, MS
AF Mohamed, Almahi I.
   Erukainure, Ochuko L.
   Salau, Veronica F.
   Islam, Md Shahidul
TI Impact of coffee and its bioactive compounds on the risks of type 2
   diabetes and its complications: A comprehensive review
SO DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS
LA English
DT Review
DE Coffee; Diabetes; Hyperglycemia; Obesity; Oxidative stress
ID DNA STRAND BREAKS; OXIDATIVE STRESS; METABOLIC SYNDROME;
   CARDIOVASCULAR-DISEASE; CHLOROGENIC ACID; ENDOTHELIAL DYSFUNCTION;
   ANTIOXIDANT ACTIVITY; INSULIN-RESISTANCE; CLIMATE-CHANGE; HEART-FAILURE
AB Background: Coffee beans have a long history of use as traditional medicine by various indigenous people. Recent focus has been given to the health benefits of coffee beans and its bioactive compounds. Research on the bioactivities, applications, and effects of processing methods on coffee beans' phytochemical composition and activities has been conducted extensively. The current review attempts to provide an update on the biological effects of coffee on type 2 diabetes (T2D) and its comorbidities. Methods: Comprehensive literature search was carried out on peer-reviewed published data on biological activities of coffee on in vitro, in vivo and epidemiological research results published from January 2015 to December 2022, using online databases such as PubMed, Google Scholar and ScienceDirect for our searches. Results: The main findings were: firstly, coffee may contribute to the prevention of oxidative stress and T2Drelated illnesses such as cardiovascular disease, retinopathy, obesity, and metabolic syndrome; secondly, consuming up to 400 mg/day (1-4 cups per day) of coffee is associated with lower risks of T2D; thirdly, caffeine consumed between 0.5 and 4 h before a meal may inhibit acute metabolic rate; and finally, both caffeinated and decaffeinated coffee are associated with reducing the risks of T2D. Conclusion: Available evidence indicates that long-term consumption of coffee is associated with decreased risk of T2D and its complications as well as decreased body weight. This has been attributed to the consumption of coffee with the abundance of bioactive chemicals.
C1 [Mohamed, Almahi I.; Erukainure, Ochuko L.; Salau, Veronica F.; Islam, Md Shahidul] Univ KwaZulu Natal, Dept Biochem, Westville Campus, ZA-4000 Durban, South Africa.
   [Erukainure, Ochuko L.] Univ KwaZulu Natal, Dept Microbiol, Westville Campus, ZA-4000 Durban, South Africa.
   [Salau, Veronica F.] Univ Free State, Dept Pharmacol, ZA-9300 Bloemfontein, South Africa.
C3 University of Kwazulu Natal; University of Kwazulu Natal; University of
   the Free State
RP Islam, MS (corresponding author), Univ KwaZulu Natal, Dept Biochem, Westville Campus, ZA-4000 Durban, South Africa.
EM islamd@ukzn.ac.za
RI Islam, Shahidul/N-5897-2013; Erukainure, Ochuko/G-9888-2014; Salau,
   Veronica/GQZ-7764-2022
OI Erukainure, Ochuko/0000-0003-0489-338X
FU National Research Foundation (NRF), Pretoria; University of
   KwaZulu-Natal, Durban, South Africa
FX This work was supported by a Incentive Grant for Rated Researchers from
   the National Research Foundation (NRF), Pretoria; and Research Rewards
   from the University of KwaZulu-Natal, Durban, South Africa.
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NR 289
TC 4
Z9 4
U1 5
U2 12
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 1871-4021
EI 1878-0334
J9 DIAB MET SYND CLIN R
JI DIABET. METAB. SYNDR. CLIN. RES. REV.
PD JUL
PY 2024
VL 18
IS 7
AR 103075
DI 10.1016/j.dsx.2024.103075
EA JUL 2024
PG 17
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA A6K2Q
UT WOS:001283597900001
PM 39067326
OA hybrid
DA 2025-06-11
ER

PT J
AU Soto-Angona, O
   Anmella, G
   Valdés-Florido, MJ
   De Uribe-Viloria, N
   Carvalho, AF
   Penninx, BWJH
   Berk, M
AF Soto-Angona, Oscar
   Anmella, Gerard
   Valdes-Florido, Maria Jose
   De Uribe-Viloria, Nieves
   Carvalho, Andre F.
   Penninx, Brenda W. J. H.
   Berk, Michael
TI Non-alcoholic fatty liver disease (NAFLD) as a neglected metabolic
   companion of psychiatric disorders: common pathways and future
   approaches
SO BMC MEDICINE
LA English
DT Review
DE Non-alcoholic fatty liver disease; Metabolic syndrome; Mental disorders;
   Psychiatry; Non-alcoholic steatohepatitis; Non-communicable disorders;
   Lifestyle; Inflammation; Oxidative stress; Mitochondrial
ID BIPOLAR DISORDER; OXIDATIVE STRESS; MENTAL-DISORDERS; RISK-FACTORS;
   HISTOLOGICAL SEVERITY; GLOBAL EPIDEMIOLOGY; PSYCHOTIC DISORDERS;
   GENDER-DIFFERENCES; PHYSICAL-ACTIVITY; GUT-MICROBIOTA
AB Background Non-alcoholic fatty liver disease (NAFLD) is characterized by hepatic steatosis in over 5% of the parenchyma in the absence of excessive alcohol consumption. It is more prevalent in patients with diverse mental disorders, being part of the comorbidity driving loss of life expectancy and quality of life, yet remains a neglected entity. NAFLD can progress to non-alcoholic steatohepatitis (NASH) and increases the risk for cirrhosis and hepatic carcinoma. Both NAFLD and mental disorders share pathophysiological pathways, and also present a complex, bidirectional relationship with the metabolic syndrome (MetS) and related cardiometabolic diseases. Main text This review compares the demographic data on NAFLD and NASH among the global population and the psychiatric population, finding differences that suggest a higher incidence of this disease among the latter. It also analyzes the link between NAFLD and psychiatric disorders, looking into common pathophysiological pathways, such as metabolic, genetic, and lifestyle factors. Finally, possible treatments, tailored approaches, and future research directions are suggested. Conclusion NAFLD is part of a complex system of mental and non-communicable somatic disorders with a common pathogenesis, based on shared lifestyle and environmental risks, mediated by dysregulation of inflammation, oxidative stress pathways, and mitochondrial function. The recognition of the prevalent comorbidity between NAFLD and mental disorders is required to inform clinical practice and develop novel interventions to prevent and treat these complex and interacting disorders.
C1 [Soto-Angona, Oscar] Vall dHebron Univ Hosp, Dept Psychiat, Passeig Vall dHebron,119-129, Barcelona 08035, Catalonia, Spain.
   [Soto-Angona, Oscar; Anmella, Gerard; De Uribe-Viloria, Nieves; Carvalho, Andre F.; Berk, Michael] Deakin Univ, Inst Mental & Phys Hlth & Clin Translat, Sch Med, IMPACT,Barwon Hlth, Geelong, Vic, Australia.
   [Anmella, Gerard] Univ Barcelona, Bipolar & Depress Disorders Unit, Inst Neurosci, Hosp Clin,IDIBAPS,CIBERSAM, 170 Villarroel St,12-0, Barcelona 08036, Catalonia, Spain.
   [Valdes-Florido, Maria Jose] Hosp Univ Virgen Macarena, UGC Salud Mental, Seville, Spain.
   [De Uribe-Viloria, Nieves] Hosp Clin Univ Valladolid, Dept Psychiat, Valladolid, Castilla & Leon, Spain.
   [Carvalho, Andre F.] Univ Toronto, Dept Psychiat, Toronto, ON, Canada.
   [Carvalho, Andre F.] Ctr Addict & Mental Hlth CAMH, Toronto, ON, Canada.
   [Penninx, Brenda W. J. H.] Vrije Univ, Amsterdam Univ, Dept Psychiat, Amsterdam Publ Hlth,Med Ctr, Amsterdam, Netherlands.
   [Penninx, Brenda W. J. H.] Vrije Univ, Amsterdam Univ, Med Ctr, Amsterdam Neurosci, Amsterdam, Netherlands.
   [Berk, Michael] GGZinGeest, Amsterdam, Netherlands.
   [Berk, Michael] Univ Melbourne, Natl Ctr Excellence Youth Mental Hlth, Dept Psychiat, Orygen, Parkville, Vic, Australia.
   [Berk, Michael] Univ Melbourne, Florey Inst Neurosci & Mental Hlth, Parkville, Vic, Australia.
C3 Hospital Universitari Vall d'Hebron; Barwon Health; Deakin University;
   CIBER - Centro de Investigacion Biomedica en Red; CIBERSAM; University
   of Barcelona; Hospital Clinic de Barcelona; IDIBAPS; Hospital
   Universitario Virgen Macarena; Universidad de Valladolid; University
   Hospital of Valladolid; University of Toronto; University of Toronto;
   Centre for Addiction & Mental Health - Canada; University of Amsterdam;
   Vrije Universiteit Amsterdam; Vrije Universiteit Amsterdam; University
   of Amsterdam; Orygen, The National Centre of Excellence in Youth Mental
   Health; University of Melbourne; Florey Institute of Neuroscience &
   Mental Health; University of Melbourne
RP Soto-Angona, O (corresponding author), Vall dHebron Univ Hosp, Dept Psychiat, Passeig Vall dHebron,119-129, Barcelona 08035, Catalonia, Spain.; Soto-Angona, O (corresponding author), Deakin Univ, Inst Mental & Phys Hlth & Clin Translat, Sch Med, IMPACT,Barwon Hlth, Geelong, Vic, Australia.
EM osoto@vhebron.net
RI Berk, Michael/AGH-9427-2022; Diaz, Gerard/AAB-7311-2021; Carvalho,
   Andre/AEZ-4001-2022; Berk, Michael/M-7891-2013; Penninx, Brenda
   WJH/S-7627-2017
OI Berk, Michael/0000-0002-5554-6946; Penninx, Brenda
   WJH/0000-0001-7779-9672; Valdes-Florido, Maria Jose/0000-0001-6036-842X;
   Soto-Angona, Oscar/0000-0003-0234-4280
FU NHMRC Senior Principal Research Fellowship [1156072]
FX MB is supported by a NHMRC Senior Principal Research Fellowship
   (1156072).
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NR 117
TC 75
Z9 77
U1 3
U2 13
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1741-7015
J9 BMC MED
JI BMC Med.
PD OCT 1
PY 2020
VL 18
IS 1
AR 261
DI 10.1186/s12916-020-01713-8
PG 14
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA NZ2PR
UT WOS:000576939100001
PM 32998725
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Eirin, A
   Woollard, JR
   Ferguson, CM
   Jordan, KL
   Tang, H
   Textor, SC
   Lerman, A
   Lerman, LO
AF Eirin, Alfonso
   Woollard, John R.
   Ferguson, Christopher M.
   Jordan, Kyra L.
   Tang, Hui
   Textor, Stephen C.
   Lerman, Amir
   Lerman, Lilach O.
TI The metabolic syndrome induces early changes in the swine renal
   medullary mitochondria
SO TRANSLATIONAL RESEARCH
LA English
DT Article
ID GLOMERULAR-FILTRATION-RATE; OXYGEN SPECIES GENERATION; OXIDATIVE STRESS;
   KIDNEY-DISEASE; BOLD MRI; REVASCULARIZATION; HYPERFILTRATION; APOPTOSIS;
   HEMODYNAMICS; PROTECTION
AB The metabolic syndrome (MetS) is associated with nutrient surplus and kidney hyperfiltration, accelerating chronic renal failure. Mitochondria can be overwhelmed by substrate excess, leading to inefficient energy production and thereby tissue hypoxia. Mitochondrial dysfunction is emerging as an important determinant of renal damage, but whether it contributes to MetS-induced renal injury remains unknown. We hypothesized that early MetS induces kidney mitochondrial abnormalities and dysfunction, which would be notable in the vulnerable renal medulla. Pigs were studied after 16 weeks of diet-induced MetS, MetS treated for the last 4 weeks with the mitochondria-targeted peptide elami-pretide (0.1 mg/kg SC q.d), and Lean controls (n = 7 each). Single-kidney renal blood flow, glomerular filtration rate, and oxygenation were measured in-vivo, whereas cortical and medullary mitochondrial structure and function and renal injurious pathways were studied ex-vivo. Blood pressure was slightly elevated in MetS pigs, and their renal blood flow and glomerular filtration rate were elevated. Blood oxygen level-dependent magnetic resonance imaging demonstrated that this was associated with medullary hypoxia, whereas cortical oxygenation remained intact. MetS decreased renal content of the inner mitochondrial membrane cardiolipin, particularly the tetra-linoleoyl (C18:2) cardiolipin species, and altered mitochondrial morphology and function, particularly in the medullary thick ascending limb. MetS also increased renal cytochrome-c-induced apoptosis, oxidative stress, and tubular injury. Chronic mitoprotection restored mitochondrial structure, ATP synthesis, and antioxidant defenses and decreased mitochondrial oxidative stress, medullary hypoxia, and renal injury. These findings implicate medullary mitochondrial damage in renal injury in experimental MetS, and position the mitochondria as a therapeutic target.
C1 [Lerman, Lilach O.] Mayo Clin, Div Nephrol & Hypertens, 200 First St SW, Rochester, MN 55905 USA.
   Mayo Clin, Cardiovasc Dis, Rochester, MN USA.
C3 Mayo Clinic; Mayo Clinic
RP Lerman, LO (corresponding author), Mayo Clin, Div Nephrol & Hypertens, 200 First St SW, Rochester, MN 55905 USA.
EM Lerman.Lilach@Mayo.Edu
RI Lerman, Lilach/M-4962-2017; Eirin, Alfonso/N-9873-2013
OI Eirin, Alfonso/0000-0002-3864-9644
FU Stealth Biotherapeutics, Inc; NIH [DK73608, DK106427, DK104273,
   HL123160, DK102325]
FX This work was supported by a research grant from Stealth
   Biotherapeutics, Inc, and from the NIH (DK73608, DK106427, DK104273,
   HL123160, and DK102325).
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NR 49
TC 30
Z9 33
U1 0
U2 6
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1931-5244
EI 1878-1810
J9 TRANSL RES
JI Transl. Res.
PD JUN
PY 2017
VL 184
BP 45
EP 56
DI 10.1016/j.trsl.2017.03.002
PG 12
WC Medical Laboratory Technology; Medicine, General & Internal; Medicine,
   Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology; General & Internal Medicine; Research &
   Experimental Medicine
GA EW1BH
UT WOS:000402224400005
PM 28363084
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Nair, AR
   Elks, CM
   Vila, J
   Del Piero, F
   Paulsen, DB
   Francis, J
AF Nair, Anand R.
   Elks, Carrie M.
   Vila, Jorge
   Del Piero, Fabio
   Paulsen, Daniel B.
   Francis, Joseph
TI A Blueberry-Enriched Diet Improves Renal Function and Reduces Oxidative
   Stress in Metabolic Syndrome Animals: Potential Mechanism of TLR4-MAPK
   Signaling Pathway
SO PLOS ONE
LA English
DT Article
ID CHRONIC KIDNEY-DISEASE; NF-KAPPA-B; MESSENGER-RNA EXPRESSION;
   TUBULOINTERSTITIAL INJURY; INSULIN-RESISTANCE; HYPERTENSIVE-RATS;
   ANGIOTENSIN-II; IN-VIVO; PROTEIN; OBESITY
AB Background: Metabolic syndrome (MetS) is characterized by a cluster of health factors that indicate a higher risk for cardiorenal diseases. Recent evidence indicates that antioxidants from berries are alternative to attenuate oxidative stress and inflammation. We tested the hypothesis that inflammation-induced renal damage is triggered by the activation of TLR4, and subsequent modulation of redox-sensitive molecules and mitogen-activated protein kinase (MAPK) pathway.
   Methods: Five-week old lean and obese Zucker rats (LZR and OZR) were fed a blueberry-enriched diet or an isocaloric control diet for 15 weeks. A glucose tolerance test and acute renal clearance experiments were performed. Gene and protein expression levels for TLR4, cytokines and phosphorylation of ERK and p38MAPK were measured. Kidney redox status and urinary albumin levels were quantified. Renal pathology was evaluated histologically.
   Results: Control OZR exhibited lower glucose tolerance; exacerbated renal function parameters; increased oxidative stress. Gene and protein expression levels of TLR4 were higher and this was accompanied by increased renal pathology with extensive albuminuria and deterioration in antioxidant levels in OZR. In addition, OZR had increased phosphorylation of ERK and p38MAPK. Blueberry-fed OZR exhibited significant improvements in all these parameters compared to OZR.
   Conclusion: TLR4-MAPK signaling pathway is a key to the renal structural injury and dysfunction in MetS and blueberry (BB) protect against this damage by inhibiting TLR4.
   Significance: This is the first study to put forth a potential mechanism of TLR4-induced kidney damage in a model of MetS and to elucidate a downstream mechanism by which blueberry exert their reno-protective effects.
C1 [Nair, Anand R.; Elks, Carrie M.; Vila, Jorge; Del Piero, Fabio; Paulsen, Daniel B.; Francis, Joseph] Louisiana State Univ, Sch Vet Med, Baton Rouge, LA 70803 USA.
   [Elks, Carrie M.] Pennington Biomed Res Ctr, Adipocyte Biol Lab, Baton Rouge, LA 70808 USA.
C3 Louisiana State University School of Veterinary Medicine; Louisiana
   State University System; Louisiana State University; Louisiana State
   University System; Louisiana State University; Pennington Biomedical
   Research Center
RP Francis, J (corresponding author), Louisiana State Univ, Sch Vet Med, Baton Rouge, LA 70803 USA.
EM jfrancis@vetmed.lsu.edu
RI Elks, Carrie/N-1961-2017; Francis, Joseph/I-4984-2012
OI Francis, Joseph/0000-0002-9502-4579
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NR 61
TC 38
Z9 40
U1 0
U2 16
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD NOV 5
PY 2014
VL 9
IS 11
AR e111976
DI 10.1371/journal.pone.0111976
PG 12
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA AS9IQ
UT WOS:000344556900099
PM 25372283
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Monserrat-Mesquida, M
   Quetglas-Llabrés, M
   Bouzas, C
   Montemayor, S
   Mascaró, CM
   Casares, M
   Llompart, I
   Gámez, JM
   Tejada, S
   Martínez, JA
   Tur, JA
   Sureda, A
AF Monserrat-Mesquida, Margalida
   Quetglas-Llabres, Magdalena
   Bouzas, Cristina
   Montemayor, Sofia
   Mascaro, Catalina M.
   Casares, Miguel
   Llompart, Isabel
   Gamez, Jose M.
   Tejada, Silvia
   Alfredo Martinez, J.
   Tur, Josep A.
   Sureda, Antoni
TI A Greater Improvement of Intrahepatic Fat Contents after 6 Months of
   Lifestyle Intervention Is Related to a Better Oxidative Stress and
   Inflammatory Status in Non-Alcoholic Fatty Liver Disease
SO ANTIOXIDANTS
LA English
DT Article
DE NAFLD; IFC; aerobic capacity; oxidative stress; inflammation; biomarkers
ID METABOLIC SYNDROME; WEIGHT-LOSS; LONG-TERM; MEDITERRANEAN DIET; HEPATIC
   STEATOSIS; PHYSICAL-ACTIVITY; NAFLD; PATHOGENESIS; PROGRESSION;
   STEATOHEPATITIS
AB Non-alcoholic fatty liver disease (NAFLD) is a disorder characterized by the excessive accumulation of lipids in the liver parenchyma. To date, there is no effective pharmacological treatment against NAFLD. Objective: To assess the relationship between the improvement of the intrahepatic fat content (IFC) in patients with NAFLD and metabolic syndrome and biomarkers of oxidative stress and inflammation after 6 months of lifestyle intervention. Patients diagnosed with NAFLD (n = 60 adults; 40-60 years old) residing in the Balearic Islands, Spain, were distributed in tertiles attending the improvement of IFC calculated by magnetic resonance imaging (MRI). Anthropometrics, blood pressure, maximal oxygen uptake, and pro/antioxidant and inflammatory biomarkers were determined in plasma before and after the lifestyle intervention. The improvement in IFC levels was higher in tertile 3 with respect to tertiles 2 and 1. The greatest improvement in IFC is related to cardiorespiratory fitness and adherence to the Mediterranean diet (ADM). Higher reductions in weight, body mass index (BMI), and alanine aminotransferase (ALT) were observed in tertile 3 with respect to tertile 1 after 6 months of intervention. The improvement in catalase, irisin, and cytokeratin 18 plasma levels were higher in tertile 3, whereas no differences were observed in superoxide dismutase activity. Malondialdehyde and protein carbonyl levels, as biomarkers of oxidative damage, remained unchanged in all groups. The present data show that the reduction of IFC is associated with an improvement in pro/antioxidant and pro-inflammatory status and a better cardiorespiratory fitness in NAFLD patients.
C1 [Monserrat-Mesquida, Margalida; Quetglas-Llabres, Magdalena; Bouzas, Cristina; Montemayor, Sofia; Mascaro, Catalina M.; Llompart, Isabel; Gamez, Jose M.; Tejada, Silvia; Tur, Josep A.; Sureda, Antoni] Univ Balearic Isl IUNICS, Res Grp Community Nutr & Oxidat Stress, Palma De Mallorca 07122, Spain.
   [Monserrat-Mesquida, Margalida; Quetglas-Llabres, Magdalena; Bouzas, Cristina; Llompart, Isabel; Gamez, Jose M.; Tejada, Silvia; Tur, Josep A.; Sureda, Antoni] Hlth Res Inst Balearic Isl IdISBa, Palma De Mallorca 07120, Spain.
   [Monserrat-Mesquida, Margalida; Bouzas, Cristina; Montemayor, Sofia; Mascaro, Catalina M.; Llompart, Isabel; Tejada, Silvia; Tur, Josep A.; Sureda, Antoni] Inst Salud Carlos III ISCIII, CIBER Fisiopatol Obesidad & Nutr CIBEROBN, Madrid 28029, Spain.
   [Casares, Miguel] Red Asistencial Juaneda, Radiodiag Serv, Palma De Mallorca 07011, Spain.
   [Llompart, Isabel] Univ Hosp Son Espases, Clin Anal Serv, Palma De Mallorca 07198, Spain.
   [Gamez, Jose M.] Univ Hosp Son Llatzer, Cardiol Serv, Palma De Mallorca 07010, Spain.
   [Tejada, Silvia] Univ Balearic Isl, Dept Biol, Lab Neurophysiol, Palma De Mallorca 07122, Spain.
   [Alfredo Martinez, J.] Inst Madrileno Estudios Avanzados Alimentac IMDEA, Cardiomet Precis Nutr Program, Madrid 28049, Spain.
C3 Institut Investigacio Sanitaria Illes Balears (IdISBa); CIBER - Centro
   de Investigacion Biomedica en Red; CIBEROBN; Hospital Universitari Son
   Espases; Hospital Universitari Son Llatzer; Universitat de les Illes
   Balears
RP Tur, JA (corresponding author), Univ Balearic Isl IUNICS, Res Grp Community Nutr & Oxidat Stress, Palma De Mallorca 07122, Spain.; Tur, JA (corresponding author), Hlth Res Inst Balearic Isl IdISBa, Palma De Mallorca 07120, Spain.; Tur, JA (corresponding author), Inst Salud Carlos III ISCIII, CIBER Fisiopatol Obesidad & Nutr CIBEROBN, Madrid 28029, Spain.
EM margalida.monserrat@uib.es; m.quetglas@uib.es; cristinabouzas@uib.es;
   sofiamf16@gmail.com; c.mascaro@uib.es; casaresmiguel@gmail.com;
   isabel.llompart@ssib.es; jmgamez@hsll.es; silvia.tejada@uib.es;
   jalfredo.martinez@imdea.org; pep.tur@uib.es; antoni.sureda@uib.es
RI Tur, Josep/AAE-5748-2020; Martínez, J./K-8709-2014; Sureda,
   Antoni/N-9588-2019; Mesquida, Margalida/AAB-4773-2019; Quetglas Llabrés,
   Maria/AAA-4412-2019; Tejada, Silvia/L-7297-2014; Bouzas,
   Cristina/AAE-2069-2019; Tur, Josep/F-5576-2014
OI , Antoni/0000-0001-8656-6838; Monserrat Mesquida,
   Margalida/0000-0002-8856-135X; Tur, Josep/0000-0002-6940-0761;
   Montemayor, Sofia/0000-0001-7833-2118; Bouzas Velasco,
   Cristina/0000-0002-1407-8461
FU Fundacio La Marato TV3 (Spain) [201630.10]; Instituto de Salud Carlos
   III through the Fondo de Investigacion para la Salud [CIBEROBN
   CB12/03/30038, CIBER OBN18PI03]; European Regional Development Fund;
   EU-COST Action [CA16112]; IDISBA Grant (FOLIUM); Spanish Ministry of
   Education; IDISBA grant; IDISBA Grant (PRIMUS); IDISBA Grant (SYNERGIA);
   IDISBA Grant (LIBERI)
FX Fundacio La Marato TV3 (Spain) project ref. 201630.10. Instituto de
   Salud Carlos III through the Fondo de Investigacion para la Salud
   (CIBEROBN CB12/03/30038 and Proyecto Intramural CIBER OBN18PI03), which
   are co-funded by the European Regional Development Fund. Other funding
   received: EU-COST Action CA16112 and IDISBA Grants (FOLIUM, PRIMUS,
   SYNERGIA, and LIBERI). M.Q.-L. was granted by IDISBA grant. C.M.M.
   received an FPU Ph.D. Grant from the Spanish Ministry of Education. The
   funding sponsors had no role in the design of the study, in the
   collection, analyses, or interpretation of the data; in the writing of
   the manuscript, or in the decision to publish the results.
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NR 70
TC 9
Z9 9
U1 0
U2 7
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD JUL
PY 2022
VL 11
IS 7
AR 1266
DI 10.3390/antiox11071266
PG 16
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA 3L0KV
UT WOS:000834460700001
PM 35883758
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Dludla, PV
   Nkambule, BB
   Nyambuya, TM
   Ziqubu, K
   Mabhida, SE
   Mxinwa, V
   Mokgalaboni, K
   Ndevahoma, F
   Hanser, S
   Mazibuko-Mbeje, SE
   Basson, AK
   Sabbatinelli, J
   Tiano, L
AF Dludla, Phiwayinkosi V. V.
   Nkambule, Bongani B. B.
   Nyambuya, Tawanda M. M.
   Ziqubu, Khanyisani
   Mabhida, Sihle E. E.
   Mxinwa, Vuyolwethu
   Mokgalaboni, Kabelo
   Ndevahoma, Fransina
   Hanser, Sidney
   Mazibuko-Mbeje, Sithandiwe E. E.
   Basson, Albertus K. K.
   Sabbatinelli, Jacopo
   Tiano, Luca
TI Vitamin C intake potentially lowers total cholesterol to improve
   endothelial function in diabetic patients at increased risk of
   cardiovascular disease: A systematic review of randomized controlled
   trials
SO FRONTIERS IN NUTRITION
LA English
DT Article
DE vitamin C; dietary supplements; antioxidants; diabetes mellitus;
   metabolic syndrome; cardiovascular diseases
ID OXIDATIVE STRESS; ASCORBIC-ACID; DIETARY-SUPPLEMENTS; GLYCEMIC CONTROL;
   BLOOD-PRESSURE; INSULIN SENSITIVITY; MELLITUS; METAANALYSIS; EXERCISE;
   HEALTH
AB Background: Vitamin C is one of the most consumed dietary compounds and contains abundant antioxidant properties that could be essential in improving metabolic function. Thus, the current systematic review analyzed evidence on the beneficial effects of vitamin C intake on cardiovascular disease (CVD)-related outcomes in patients with diabetes or metabolic syndrome. Methods: To identify relevant randomized control trials (RCTs), a systematic search was run using prominent search engines like PubMed and Google Scholar, from beginning up to March 2022. The modified Black and Downs checklist was used to assess the quality of evidence. Results: Findings summarized in the current review favor the beneficial effects of vitamin C intake on improving basic metabolic parameters and lowering total cholesterol levels to reduce CVD-risk in subjects with type 2 diabetes or related metabolic diseases. Moreover, vitamin C intake could also reduce the predominant markers of inflammation and oxidative stress like C-reactive protein, interleukin-6, and malondialdehyde. Importantly, these positive outcomes were consistent with improved endothelial function or increased blood flow in these subjects. Predominantly effective doses were 1,000 mg/daily for 4 weeks up to 12 months. The included RCTs presented with the high quality of evidence. Conclusion: Clinical evidence on the beneficial effects of vitamin C intake or its impact on improving prominent markers of inflammation and oxidative stress in patients with diabetes is still limited. Thus, more RCTs are required to solidify these findings, which is essential to better manage diabetic patients at increased risk of developing CVD.
C1 [Dludla, Phiwayinkosi V. V.; Mabhida, Sihle E. E.] South African Med Res Council, Biomed Res & Innovat Platform, Tygerberg, South Africa.
   [Dludla, Phiwayinkosi V. V.; Basson, Albertus K. K.] Univ Zululand, Dept Biochem & Microbiol, Kwa Dlangezwa, South Africa.
   [Nkambule, Bongani B. B.; Mxinwa, Vuyolwethu; Mokgalaboni, Kabelo] Univ KwaZulu Natal, Sch Lab Med & Med Sci, Durban, South Africa.
   [Nyambuya, Tawanda M. M.; Ndevahoma, Fransina] Namibia Univ Sci & Technol, Dept Hlth Sci, Windhoek, Namibia.
   [Ziqubu, Khanyisani; Mazibuko-Mbeje, Sithandiwe E. E.] North West Univ, Dept Biochem, Mmabatho, South Africa.
   [Mokgalaboni, Kabelo] Univ South Africa, Dept Life & Consumer Sci, Florida Campus, Roodepoort, South Africa.
   [Hanser, Sidney] Univ Limpopo, Dept Physiol & Environm Hlth, Sovenga, South Africa.
   [Sabbatinelli, Jacopo] Polytech Univ Marche, Dept Clin & Mol Sci, Ancona, Italy.
   [Tiano, Luca] Polytech Univ Marche, Dept Life & Environm Sci, Ancona, Italy.
C3 South African Medical Research Council; University of Zululand;
   University of Kwazulu Natal; Namibia University of Science & Technology;
   North West University - South Africa; University of South Africa;
   University of Limpopo; Marche Polytechnic University; Marche Polytechnic
   University
RP Dludla, PV (corresponding author), South African Med Res Council, Biomed Res & Innovat Platform, Tygerberg, South Africa.; Dludla, PV (corresponding author), Univ Zululand, Dept Biochem & Microbiol, Kwa Dlangezwa, South Africa.
EM pdludla@mrc.ac.za
RI Nyambuya, Tawanda Maurice/GLU-4124-2022; Nkambule,
   Bongani/ABD-7943-2022; Mazibuko-Mbeje, Sithandiwe/HPG-1119-2023;
   Mokgalaboni, Kabelo/ACZ-1282-2022; Tiano, Luca/ABC-2341-2020;
   Sabbatinelli, Jacopo/U-1851-2018
OI Mokgalaboni, Kabelo/0000-0002-3224-7433; Sabbatinelli,
   Jacopo/0000-0001-9947-6778; Mabhida, Sihle/0000-0002-8388-132X;
   Nyambuya, Tawanda Maurice/0000-0002-3288-9524; Nkambule,
   Bongani/0000-0001-8846-1992
FU South African Medical Research Council (SAMRC); National Research
   Foundation [117829];  [141929]
FX This work was supported in part by baseline funding from the Biomedical
   Research and Innovation Platform of the South African Medical Research
   Council (SAMRC) and the National Research Foundation (Grant numbers:
   141929 and 117829).
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NR 78
TC 20
Z9 20
U1 3
U2 11
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD OCT 31
PY 2022
VL 9
AR 1011002
DI 10.3389/fnut.2022.1011002
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 6H4BS
UT WOS:000885387900001
PM 36386907
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Xu, ZQ
   Elrashidy, RA
   Li, B
   Liu, GM
AF Xu, Zhenqun
   Elrashidy, Rania A.
   Li, Bo
   Liu, Guiming
TI Oxidative Stress: A Putative Link Between Lower Urinary Tract Symptoms
   and Aging and Major Chronic Diseases
SO FRONTIERS IN MEDICINE
LA English
DT Review
DE lower urinary tract symptoms (LUTS); oxidative stress; aging; chronic
   diseases; bladder
ID BENIGN PROSTATIC HYPERPLASIA; BLADDER OUTLET OBSTRUCTION;
   QUALITY-OF-LIFE; METABOLIC SYNDROME; OVERACTIVE BLADDER;
   PARKINSONS-DISEASE; SLEEP-APNEA; ANTIOXIDANT ENZYMES; URETHRAL
   SPHINCTER; ALZHEIMERS-DISEASE
AB Aging and major chronic diseases are risk factors for lower urinary tract symptoms (LUTS). On the other hand, oxidative stress (OS) is one of the fundamental mechanisms of aging and the development of chronic diseases. Therefore, OS might be a candidate mechanism linking these two clinical entities. This article aims to summarize the studies on the prevalence of LUTS, the role of OS in aging and chronic diseases, and the potential mechanisms supporting the putative link. A comprehensive literature search was performed to identify recent reports investigating LUTS and OS in major chronic diseases. In addition, studies on the impact of OS on the lower urinary tract, including bladder, urethra, and prostate, were collected and summarized. Many studies showed LUTS are prevalent in aging and major chronic diseases, including obesity, metabolic syndrome, diabetes, cardiovascular disease, hypertension, obstructive sleep apnea, autoimmune diseases, Alzheimer's disease, and Parkinson's disease. At the same time, OS is a key component in the pathogenesis of those chronic diseases and conditions. Recent studies also provided evidence that exacerbated OS can cause functional and/or structural changes in the bladder, urethra, and prostate, leading to LUTS. The reviewed data support the concept that OS is involved in multiple risk factors-associated LUTS, although further studies are needed to confirm the causative relationship. The specific ROS/RNS and corresponding reactions/pathways involved in chronic diseases and associated LUTS should be identified in the future and could serve as therapeutic targets.
C1 [Xu, Zhenqun; Li, Bo; Liu, Guiming] Case Western Reserve Univ, Dept Surg, MetroHlth Med Ctr, Cleveland, OH 44106 USA.
   [Xu, Zhenqun; Li, Bo] China Med Univ, Shengjing Hosp, Dept Urol, Shenyang, Peoples R China.
   [Elrashidy, Rania A.] Zagazig Univ, Fac Pharm, Dept Biochem, Zagazig, Egypt.
C3 University System of Ohio; Case Western Reserve University; MetroHealth
   System; China Medical University; Egyptian Knowledge Bank (EKB); Zagazig
   University
RP Liu, GM (corresponding author), Case Western Reserve Univ, Dept Surg, MetroHlth Med Ctr, Cleveland, OH 44106 USA.
EM guiming.liu@case.edu
RI Elrashidy, Rania/HLW-2856-2023
OI Elrashidy, Rania/0000-0001-8383-8383
FU National Institutes of Health (NIH) NIDDK [R01-DK110567]
FX Funding GL was supported by the National Institutes of Health (NIH)
   NIDDK grant R01-DK110567.
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NR 213
TC 20
Z9 20
U1 1
U2 15
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 2296-858X
J9 FRONT MED-LAUSANNE
JI Front. Med.
PD MAR 10
PY 2022
VL 9
AR 812967
DI 10.3389/fmed.2022.812967
PG 15
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 0F4GV
UT WOS:000777320300001
PM 35360727
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Sanchez-Lozada, LG
   Andres-Hernando, A
   Garcia-Arroyo, FE
   Cicerchi, C
   Li, NX
   Kuwabara, M
   Roncal-Jimenez, CA
   Johnson, RJ
   Lanaspa, MA
AF Sanchez-Lozada, Laura G.
   Andres-Hernando, Ana
   Garcia-Arroyo, Fernando E.
   Cicerchi, Christina
   Li, Nanxing
   Kuwabara, Masanari
   Roncal-Jimenez, Carlos A.
   Johnson, Richard J.
   Lanaspa, Miguel A.
TI Uric acid activates aldose reductase and the polyol pathway for
   endogenous fructose and fat production causing development of fatty
   liver in rats
SO JOURNAL OF BIOLOGICAL CHEMISTRY
LA English
DT Article
DE fructose; uric acid; metabolic syndrome; liver metabolism; fatty acid;
   aldose reductase; polyol pathway; sorbitol
ID TRANSCRIPTIONAL ACTIVATOR; CELL-PROLIFERATION; METABOLIC SYNDROME;
   HYPERTONIC STRESS; DIETARY FRUCTOSE; OXIDATIVE STRESS; EXPRESSION;
   DISEASE; CONSUMPTION; CHILDREN
AB Dietary, fructose-containing sugars have been strongly associated with the development of nonalcoholic fatty liver disease (NAFLD). Recent studies suggest that fructose also can be produced via the polyol pathway in the liver, where it may induce hepatic fat accumulation. Moreover, fructose metabolism yields uric acid, which is highly associated with NAFLD. Here, using biochemical assays, reporter gene expression, and confocal fluorescence microscopy, we investigated whether uric acid regulates aldose reductase, a key enzyme in the polyol pathway. We evaluated whether soluble uric acid regulates aldose reductase expression both in cultured hepatocytes (HepG2 cells) and in the liver of hyperuricemic rats and whether this stimulation is associated with endogenous fructose production and fat accumulation. Uric acid dose-dependently stimulated aldose reductase expression in the HepG2 cells, and this stimulation was associated with endogenous fructose production and triglyceride accumulation. This stimulatory mechanism was mediated by uric acid-induced oxidative stress and stimulation of the transcription factor nuclear factor of activated T cells 5 (NFAT5). Uric acid also amplified the effects of elevated glucose levels to stimulate hepatocyte triglyceride accumulation. Hyperuricemic rats exhibited elevated hepatic aldose reductase expression, endogenous fructose accumulation, and fat buildup that was significantly reduced by co-administration of the xanthine oxidase inhibitor allopurinol. These results suggest that uric acid generated during fructose metabolism may act as a positive feedback mechanism that stimulates endogenous fructose production by stimulating aldose reductase in the polyol pathway. Our findings suggest an amplifying mechanism whereby soft drinks rich in glucose and fructose can induce NAFLD.
C1 [Sanchez-Lozada, Laura G.; Garcia-Arroyo, Fernando E.] Inst Nacl Cardiol Ignacio Chavez, Lab Renal Physiopathol, Mexico City 14080, DF, Mexico.
   [Andres-Hernando, Ana; Cicerchi, Christina; Li, Nanxing; Kuwabara, Masanari; Roncal-Jimenez, Carlos A.; Johnson, Richard J.; Lanaspa, Miguel A.] Univ Colorado, Sch Med, Div Renal Dis & Hypertens, Aurora, CO 80045 USA.
C3 National Institute of Cardiology - Mexico; University of Colorado
   System; University of Colorado Anschutz Medical Campus
RP Lanaspa, MA (corresponding author), Univ Colorado, Sch Med, Div Renal Dis & Hypertens, Aurora, CO 80045 USA.
EM miguel.lanaspagarcia@ucdenver.edu
RI Sanchez-Lozada, Laura/AAS-2104-2021; Lanaspa, Miguel/AAO-4971-2020;
   Kuwabara, Masanari/O-9844-2017
OI Kuwabara, Masanari/0000-0002-6601-4347; Garcia Arroyo, Fernando
   Enrique/0000-0003-1545-9765; Sanchez-Lozada,
   Laura-Gabriela/0000-0003-0348-9617; Andres-Hernando,
   Ana/0000-0002-0676-0188; Lanaspa, Miguel/0000-0002-1163-1831
FU National Institutes of Health [NIDDK 1R01DK109408-01A1, NIDDK R01
   DK108859-01]
FX This work was supported by National Institutes of Health Grants NIDDK
   1R01DK109408-01A1 and NIDDK R01 DK108859-01. Some of the authors are
   members of Colorado Research Partners LLC, a start-up company developing
   inhibitors of fructose metabolism (M. A. L., A. A.-H., C. A. R.-J., R.
   J. J., and L. G. S.-L.). Dr. Johnson also has equity with a start-up
   company (XORT Therapeutics) developing novel xanthine oxidase
   inhibitors. The content is solely the responsibility of the authors and
   does not necessarily represent the official views of the National
   Institutes of Health.
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NR 63
TC 83
Z9 93
U1 2
U2 44
PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
PI ROCKVILLE
PA 11200 ROCKVILLE PIKE, SUITE 302, ROCKVILLE, MD, UNITED STATES
SN 0021-9258
EI 1083-351X
J9 J BIOL CHEM
JI J. Biol. Chem.
PD MAR 15
PY 2019
VL 294
IS 11
BP 4272
EP 4281
DI 10.1074/jbc.RA118.006158
PG 10
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA HP7FZ
UT WOS:000461854400036
PM 30651350
OA Green Published
DA 2025-06-11
ER

PT J
AU Papaccio, F
   Ottaviani, M
   Truglio, M
   D'Arino, A
   Caputo, S
   Pacifico, A
   Iacovelli, P
   Di Nardo, A
   Picardo, M
   Bellei, B
AF Papaccio, Federica
   Ottaviani, Monica
   Truglio, Mauro
   D'Arino, Andrea
   Caputo, Silvia
   Pacifico, Alessia
   Iacovelli, Paolo
   Di Nardo, Anna
   Picardo, Mauro
   Bellei, Barbara
TI Markers of Metabolic Abnormalities in Vitiligo Patients
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE vitiligo; comorbidities; metabolic syndrome; inflammation
ID POLYUNSATURATED FATTY-ACIDS; OXIDATIVE STRESS; SUPEROXIDE-DISMUTASE;
   INSULIN-RESISTANCE; SERUM; PATHOGENESIS; ASSOCIATION; PLASMA; IL-17;
   HOMOCYSTEINE
AB While vitiligo is primarily caused by melanocyte deficiency or dysfunction, recent studies have revealed a notable prevalence of metabolic syndrome (MetS) among patients with vitiligo. This suggests shared pathogenic features between the two conditions. Individuals with vitiligo often exhibit variations in triglyceride levels, cholesterol, and blood pressure, which are also affected in MetS. Given the similarities in their underlying mechanisms, genetic factors, pro-inflammatory signalling pathways, and increased oxidative stress, this study aims to highlight the common traits between vitiligo and metabolic systemic disorders. Serum analyses confirmed increased low-density lipoprotein (LDL) levels in patients with vitiligo, compared to physiological values. In addition, we reported significant decreases in folate and vitamin D (Vit D) levels. Oxidative stress is one of the underlying causes of the development of metabolic syndromes and is related to the advancement of skin diseases. This study found high levels of inflammatory cytokines, such as interleukin-6 (IL-6) and chemokine 10 (CXCL10), which are markers of inflammation and disease progression. The accumulation of insulin growth factor binding proteins 5 (IGFBP5) and advanced glycation end products (AGEs) entailed in atherosclerosis and diabetes onset, respectively, were also disclosed in vitiligo. In addition, the blood-associated activity of the antioxidant enzymes catalase (Cat) and superoxide dismutase (SOD) was impaired. Moreover, the plasma fatty acid (FAs) profile analysis showed an alteration in composition and specific estimated activities of FAs biosynthetic enzymes resembling MetS development, resulting in an imbalance towards pro-inflammatory n6-series FAs. These results revealed a systemic metabolic alteration in vitiligo patients that could be considered a new target for developing a more effective therapeutic approach.
C1 [Papaccio, Federica; Ottaviani, Monica; Caputo, Silvia; Di Nardo, Anna; Bellei, Barbara] IRCCS, Lab Cutaneous Physiopathol, I-00144 Rome, Italy.
   [Papaccio, Federica; Ottaviani, Monica; Caputo, Silvia; Di Nardo, Anna; Bellei, Barbara] IRCCS, San Gallicano Dermatol Inst, Integrated Ctr Metabol Res, I-00144 Rome, Italy.
   [Truglio, Mauro] IRCCS, San Gallicano Dermatol Inst, Microbiol & Virol, I-00144 Rome, Italy.
   [D'Arino, Andrea] IRCCS, San Gallicano Dermatol Inst, Oncol & Preventat Dermatol, I-00144 Rome, Italy.
   [Pacifico, Alessia; Iacovelli, Paolo] IRCCS, San Gallicano Dermatol Inst, Phototherapy Unit, Clin Dermatol, I-00144 Rome, Italy.
   [Picardo, Mauro] IDI IRCCS, Ist Dermopat Immacolata, I-00167 Rome, Italy.
C3 IRCCS Istituti Fisioterapici Ospitalieri (IFO); IRCCS San Gallicano
   Dermatological Institute (ISG); IRCCS Istituti Fisioterapici Ospitalieri
   (IFO); IRCCS San Gallicano Dermatological Institute (ISG); IRCCS
   Istituti Fisioterapici Ospitalieri (IFO); IRCCS San Gallicano
   Dermatological Institute (ISG); IRCCS Istituti Fisioterapici Ospitalieri
   (IFO); IRCCS San Gallicano Dermatological Institute (ISG); IRCCS
   Istituto Dermopatico dell'Immacolata (IDI)
RP Papaccio, F (corresponding author), IRCCS, Lab Cutaneous Physiopathol, I-00144 Rome, Italy.; Papaccio, F (corresponding author), IRCCS, San Gallicano Dermatol Inst, Integrated Ctr Metabol Res, I-00144 Rome, Italy.
EM federica.papaccio@ifo.it; monica.ottaviani@ifo.it
RI Papaccio, Federica/M-4127-2018; Truglio, Mauro/GWC-0198-2022; di nardo,
   anna/AAI-1629-2020; D'Arino, Andrea/AAB-2065-2021; Caputo,
   Silvia/Y-7341-2018; Ottaviani, Monica/J-3183-2016; Bellei,
   Barbara/K-5288-2016
OI D'Arino, Andrea/0000-0002-0669-1442; Di Nardo, Anna/0000-0002-5575-9968;
   Ottaviani, Monica/0000-0002-6613-2570; Truglio,
   Mauro/0000-0003-3046-3922; Bellei, Barbara/0000-0002-3883-5500
FU Italian Ministry of Health (Ricerca Corrente 2024) [2024]; Italian
   Ministry of Health
FX This research was supported by a grant from the Italian Ministry of
   Health (Ricerca Corrente 2024).
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NR 89
TC 6
Z9 6
U1 0
U2 1
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD SEP
PY 2024
VL 25
IS 18
AR 10201
DI 10.3390/ijms251810201
PG 13
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA H5E7Y
UT WOS:001323679100001
PM 39337683
OA gold
DA 2025-06-11
ER

PT J
AU Patel, TP
   Rawal, K
   Bagchi, AK
   Akolkar, G
   Bernardes, N
   Dias, DD
   Gupta, S
   Singal, PK
AF Patel, Tushar P.
   Rawal, Komal
   Bagchi, Ashim K.
   Akolkar, Gauri
   Bernardes, Nathalia
   Dias, Danielle da Silva
   Gupta, Sarita
   Singal, Pawan K.
TI Insulin resistance: an additional risk factor in the pathogenesis of
   cardiovascular disease in type 2 diabetes
SO HEART FAILURE REVIEWS
LA English
DT Article
DE Insulin resistance; CVD; Dyslipidemia; Metabolic syndrome; Oxidative
   stress; Inflammation
ID PLASMINOGEN-ACTIVATOR INHIBITOR-1; MITOCHONDRIAL SUPEROXIDE-PRODUCTION;
   CARDIAC AUTONOMIC NEUROPATHY; NITRIC-OXIDE SYNTHASE; OXIDATIVE STRESS;
   ENDOTHELIAL DYSFUNCTION; ADIPOSE-TISSUE; ANGIOTENSIN-II; POTENTIAL ROLE;
   GENE-EXPRESSION
AB Sedentary life style and high calorie dietary habits are prominent leading cause of metabolic syndrome in modern world. Obesity plays a central role in occurrence of various diseases like hyperinsulinemia, hyperglycemia and hyperlipidemia, which lead to insulin resistance and metabolic derangements like cardiovascular diseases (CVDs) mediated by oxidative stress. The mortality rate due to CVDs is on the rise in developing countries. Insulin resistance (IR) leads to micro or macro angiopathy, peripheral arterial dysfunction, hampered blood flow, hypertension, as well as the cardiomyocyte and the endothelial cell dysfunctions, thus increasing risk factors for coronary artery blockage, stroke and heart failure suggesting that there is a strong association between IR and CVDs. The plausible linkages between these two pathophysiological conditions are altered levels of insulin signaling proteins such as IR-beta, IRS-1, PI3K, Akt, Glut4 and PGC-1 alpha that hamper insulin-mediated glucose uptake as well as other functions of insulin in the cardiomyocytes and the endothelial cells of the heart. Reduced AMPK, PFK-2 and elevated levels of NADP(H)-dependent oxidases produced by activated M1 macrophages of the adipose tissue and elevated levels of circulating angiotensin are also cause of CVD in diabetes mellitus condition. Insulin sensitizers, angiotensin blockers, superoxide scavengers are used as therapeutics in the amelioration of CVD. It evidently becomes important to unravel the mechanisms of the association between IR and CVDs in order to formulate novel efficient drugs to treat patients suffering from insulin resistance-mediated cardiovascular diseases. The possible associations between insulin resistance and cardiovascular diseases are reviewed here.
C1 [Patel, Tushar P.; Rawal, Komal; Gupta, Sarita] Maharaja Sayajirao Univ Baroda, Fac Sci, Dept Biochem, Mol Endocrinol & Stem Cell Res Lab, Vadodara 390002, Gujarat, India.
   [Bagchi, Ashim K.; Akolkar, Gauri; Bernardes, Nathalia; Dias, Danielle da Silva; Singal, Pawan K.] Univ Manitoba, Inst Cardiovasc Sci, St Boniface Res Ctr, Dept Physiol & Pathophysiol,Fac Hlth Sci, Winnipeg, MB R2H 2A6, Canada.
C3 Maharaja Sayajirao University Baroda; University of Manitoba; Saint
   Boniface Hospital; Children's Hospital Research Institute of Manitoba
RP Gupta, S (corresponding author), Maharaja Sayajirao Univ Baroda, Fac Sci, Dept Biochem, Mol Endocrinol & Stem Cell Res Lab, Vadodara 390002, Gujarat, India.
EM sglmescrl@gmail.com
RI da Silva Dias, Danielle/AAN-7618-2020; Patel, Tushar/AFL-3979-2022;
   Bagchi, Ashim/AAY-8074-2020; Bernardes, Nathalia/L-7460-2015; Patel,
   Tushar P/G-4006-2013
OI Patel, Tushar P/0000-0002-7823-2579
FU St. Boniface Hospital and Research Foundation
FX Prof. Sarita Gupta was a visiting scientist in Institute of
   Cardiovascular Sciences. Nathalia Bernardes and Danielle da Silva Dias
   were exchange students, under the Canada-Brazil Training program. Dr.
   Pawan Singal is the holder of the Dr. Naranjan S. Dhalla Chair in
   Cardiovascular Research supported by St. Boniface Hospital and Research
   Foundation.
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NR 117
TC 178
Z9 198
U1 0
U2 40
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1382-4147
EI 1573-7322
J9 HEART FAIL REV
JI Heart Fail. Rev.
PD JAN
PY 2016
VL 21
IS 1
BP 11
EP 23
DI 10.1007/s10741-015-9515-6
PG 13
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA DB0FH
UT WOS:000368183500002
PM 26542377
DA 2025-06-11
ER

PT J
AU Zhang, YM
   Zhang, ZY
   Wang, RX
AF Zhang, Yu-Min
   Zhang, Zhen-Ye
   Wang, Ru-Xing
TI Protective Mechanisms of Quercetin Against Myocardial Ischemia
   Reperfusion Injury
SO FRONTIERS IN PHYSIOLOGY
LA English
DT Review
DE quercetin; ischemia; reperfusion injury; oxidative stress;
   vasodilatation; calcium overload
ID OXIDATIVE STRESS; NITRIC-OXIDE; NADPH OXIDASES; ETB RECEPTORS;
   CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; CORONARY-ARTERIES;
   UP-REGULATION; IN-VITRO; APOPTOSIS
AB Quercetin has attracted more attention in recent years due to its protective role against ischemia/reperfusion injury. Quercetin can alleviate oxidative stress injury through the inhibition of NADPH oxidase and xanthine oxidase, blockage of the Fenton reaction, and scavenging of reactive oxygen species. Quercetin can also exert anti-inflammatory and anti-apoptotic effects by reducing the response to inflammatory factors and inhibiting cell apoptosis. Moreover, it can induce vasodilation effects through the inhibition of endothelin-1 receptors, the enhancement of NO stimulation and the activation of the large-conductance calcium-activated potassium channels. Finally, Quercetin can also antagonize the calcium overload. These multifaceted activities of Quercetin make it a potential therapeutic alternative for the treatment of ischemia/reperfusion injury.
C1 [Zhang, Yu-Min; Zhang, Zhen-Ye; Wang, Ru-Xing] Nanjing Med Univ, Wuxi Peoples Hosp, Dept Cardiol, Wuxi, Jiangsu, Peoples R China.
C3 Nanjing Medical University; Jiangnan University
RP Wang, RX (corresponding author), Nanjing Med Univ, Wuxi Peoples Hosp, Dept Cardiol, Wuxi, Jiangsu, Peoples R China.
EM ruxingw@aliyun.com
RI Zhang, Zhenye/AAC-6226-2022
FU National Natural Science Foundation of China [81770331]; Natural Science
   Foundation of Jiangsu Province [BK20151110]
FX This study was supported in part by grants from the National Natural
   Science Foundation of China (81770331) and the Natural Science
   Foundation of Jiangsu Province (BK20151110).
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NR 99
TC 70
Z9 76
U1 0
U2 15
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-042X
J9 FRONT PHYSIOL
JI Front. Physiol.
PD JUL 31
PY 2020
VL 11
AR 956
DI 10.3389/fphys.2020.00956
PG 12
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA ND1KH
UT WOS:000561664400001
PM 32848878
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Ma, SL
   Ju, PJ
   Xia, QR
   Pan, ZD
   Gao, JL
   Zhang, LF
   Gao, H
   Yan, JW
   Zhang, J
   Wang, KM
   Li, C
   Xie, W
   Zhu, CZ
AF Ma, Shenglan
   Ju, Peijun
   Xia, Qingrong
   Pan, Zhongde
   Gao, Jianliang
   Zhang, Loufeng
   Gao, Hua
   Yan, Junwei
   Zhang, Jie
   Wang, Keming
   Li, Chao
   Xie, Wen
   Zhu, Cuizhen
TI Automatic Thoughts, Self-Stigma, and Resilience Among Schizophrenia
   Patients with Metabolic Syndrome: A Cross-Sectional Study
SO NEUROPSYCHIATRIC DISEASE AND TREATMENT
LA English
DT Article
DE years of education; negative symptoms; waist circumstance
ID QUALITY-OF-LIFE; INTERNALIZED STIGMA; DRUG-NAIVE; PEOPLE; PSYCHOSIS;
   ILLNESS; SCALE
AB Purpose: The study aims to clarify the negative psychological state and resilience impairments of schizophrenia (SCZ) with metabolic syndrome (MetS) while evaluating their potential as risk factors.Patients and Methods: We recruited 143 individuals and divided them into three groups. Participants were evaluated using the Positive and Negative Syndrome Scale (PANSS), Hamilton Depression Rating Scale (HAMD)-24, Hamilton Anxiety Rating Scale (HAMA)-14, Automatic Thoughts Questionnaire (ATQ), Stigma of Mental Illness scale and Connor-Davidson Resilience Scale (CDRISC). Serum biochemical parameters were measured by automatic biochemistry analyzer.Results: The score of ATQ was highest in the MetS group (F = 14.5, p < 0.001), and the total score of CD-RISC, subscale tenacity score and subscale strength score of CD-RISC were lowest in the MetS group (F = 8.54, p < 0.001; F = 5.79, p = 0.004; F = 10.9, p < 0.001). A stepwise regression analysis demonstrated that a negative correlation was observed among the ATQ with employment status, high-density lipoprotein (HDL-C), and CD-RISC (13=-0.190, t=-2.297, p = 0.023; 13=-0.278, t=-3.437, p = 0.001; 13=-0.238, t= -2.904, p = 0.004). A positive correlation was observed among the ATQ with waist, TG, WBC, and stigma (13=0.271, t = 3.340, p = 0.001; 13=0.283, t = 3.509, p = 0.001; 13=0.231, t = 2.815, p = 0.006; 13=0.251, t=-2.504, p = 0.014). The area under the receiveroperating characteristic curve analysis showed that among all independent predictors of ATQ, the TG, waist, HDL-C, CD-RISC, and stigma presented excellent specificity at 0.918, 0.852, 0.759, 0.633, and 0.605, respectively.Conclusion: Results suggested that the non-MetS and MetS groups had grievous sense of stigma, particularly, high degree of ATQ and resilience impairment was shown by the MetS group. The TG, waist, HDL-C of metabolic parameters, CD-RISC, and stigma presented excellent specificity to predict ATQ, and the waist showed excellent specificity to predict low resilience level.
C1 [Ma, Shenglan; Xia, Qingrong; Gao, Jianliang; Zhang, Loufeng; Gao, Hua; Yan, Junwei; Zhang, Jie; Wang, Keming; Li, Chao; Xie, Wen; Zhu, Cuizhen] Anhui Med Univ, Affiliated Psychol Hosp, 316 Huangshan Rd, Hefei 230022, Anhui, Peoples R China.
   [Ma, Shenglan; Xia, Qingrong; Gao, Jianliang; Zhang, Loufeng; Gao, Hua; Yan, Junwei; Zhang, Jie; Wang, Keming; Li, Chao; Xie, Wen; Zhu, Cuizhen] Hefei Fourth Peoples Hosp, Clin Ctr Psychiat & Mental Hlth, Hefei 230022, Peoples R China.
   [Ma, Shenglan; Xia, Qingrong; Gao, Jianliang; Zhang, Loufeng; Gao, Hua; Yan, Junwei; Zhang, Jie; Wang, Keming; Li, Chao; Xie, Wen; Zhu, Cuizhen] Anhui Mental Hlth Ctr, Hefei, Peoples R China.
   [Ju, Peijun] Shanghai Jiao Tong Univ, Shanghai Inst Tradit Chinese Med Mental Hlth, Sch Med, Shanghai Mental Hlth Ctr, Shanghai, Peoples R China.
   [Pan, Zhongde] Acad Forens Sci, Shanghai Key Lab Forens Med, Shanghai, Peoples R China.
C3 Anhui Medical University; Shanghai Jiao Tong University
RP Xie, W; Zhu, CZ (corresponding author), Anhui Med Univ, Affiliated Psychol Hosp, 316 Huangshan Rd, Hefei 230022, Anhui, Peoples R China.
EM xiewen0808@sina.com; zhucuizhen88@126.com
RI Wang, Keming/AAY-8013-2021
FU central public welfare research institutes [GY2020G-3]; Applied medicine
   research project of Hefei Health Committee [Hwk2020zd0016]; Applied
   medicine research project of Anhui Health Committee [AHWJ2021a036]; Key
   research and development plan projects in Anhui Province [2022e07020002]
FX Acknowledgments This study was supported by funding of central public
   welfare research institutes (grant number: GY2020G-3) , Applied medicine
   research project of Hefei Health Committee (grant number: Hwk2020zd0016)
   and Applied medicine research project of Anhui Health Committee (grant
   number: AHWJ2021a036) and Key research and development plan projects in
   Anhui Province (grant number: 2022e07020002) . The funding sources had
   no involvement in study design, collection, analysis, writing of this
   paper and publication.
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   Zhang XY, 2022, NEUROPSYCH DIS TREAT, V18, P1087, DOI 10.2147/NDT.S367392
NR 51
TC 3
Z9 3
U1 4
U2 12
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
EI 1178-2021
J9 NEUROPSYCH DIS TREAT
JI Neuropsychiatr. Dis. Treat.
PY 2023
VL 19
BP 1195
EP 1206
DI 10.2147/NDT.S407662
PG 12
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Psychiatry
GA H2KX0
UT WOS:000994316200001
PM 37220563
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Bitzer, J
   Platano, G
   Tschudin, S
   Alder, J
AF Bitzer, Johannes
   Platano, Giacomo
   Tschudin, S.
   Alder, Judith
TI Sexual counseling for women in the context of physical diseases - A
   teaching model for physicians
SO JOURNAL OF SEXUAL MEDICINE
LA English
DT Article
DE sexual dysfunction; physical diseases; pathogenetic model; diagnostic
   workup; training module
ID BREAST-CANCER SURVIVORS; QUALITY-OF-LIFE; RADICAL HYSTERECTOMY;
   BODY-IMAGE; DYSFUNCTION; POPULATION; ADJUSTMENT; DESIRE; ASSOCIATION;
   PREVALENCE
AB Introduction. Chronic medical conditions are frequently associated with sexual difficulties and problems, which are often underreported and underdiagnosed. Patients may feel that sexual problems in the context of disease are not important enough to be mentioned to their physicians, and physicians may feel uncomfortable and sometimes incompetent. Furthermore, the diagnostic criteria of Diagnostic and Statistical Manual of Mental Disorders-IV and International Classification of Diseases-10 are focused on the phenomenology of the sexual response without any specificity regarding diseases.
   Aim. To facilitate access for patients and physicians, we wanted to develop a tool for assessment and discussion of sexual problems in the context of disease. This tool should be broadly applicable, easy to use and learn for nonmental health professionals.
   Main Outcome Measures. Content analysis with respect to the integration of general sexological and disease-specific dimensions. Formulation of a diagnostic and therapeutic algorithm that can be used as a teaching tool.
   Methods. Based on our experience as a liaison-consultation sexological division of the university hospital of Basel, we analyzed the sexological diagnostic workup performed with the following group of female patients: women with benign gynecologic conditions; women with incontinence; oncological patients (mammary carcinoma, genital carcinoma); neurological patients (multiple sclerosis, spine injury, Parkinson's); patients with metabolic and endocrine disorders (diabetes, metabolic syndrome, polycystic ovarian syndrome); and patients with mental health disorders (depression, anxiety disorder, schizophrenia). We extracted the commonly used steps in the workup to construct a tool with easy-to-remember elements, which would help the physician to evaluate patients' sexual problems and plan for referral or therapy.
   Results. We could differentiate three diagnostic dimensions. The first were person-related preexisting factors, such as sexual satisfaction and function, age, body image, and general well-being. The second were the disease-specific implications, which could be summarized under the 8 Ds: Danger, Destruction, Disfigurement, Disability and pain, Dysfunction, Dysregulation, Disease load, and Drugs. The third was the patient's and partner's general response to the disease determined by affective response, coping style, body image impact, and changes in relationship dynamics.
   Conclusion. Sexual problems are frequent in many clinical conditions, but are not yet a routine part of diagnostic workup and therapeutic planning. We have developed a tool to help physicians in different clinical settings to evaluate sexual problems of the female patients with specific clinical conditions in order to facilitate access to recognition and possible treatment.
C1 Univ Basel Hosp, Dept Obstet & Gynecol, CH-4031 Basel, Switzerland.
   Univ Basel Hosp, Dept Gynecol Social Med & Psychosomat, CH-4031 Basel, Switzerland.
   Univ Basel Hosp, Dept Clin Psychol & Psychotherapy, CH-4031 Basel, Switzerland.
C3 University of Basel; University of Basel; University of Basel
RP Bitzer, J (corresponding author), Univ Basel Hosp, Dept Obstet & Gynecol, Spitalstr 21, CH-4031 Basel, Switzerland.
EM jbitzer@uhbs.ch
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NR 51
TC 55
Z9 63
U1 0
U2 20
PU BLACKWELL PUBLISHING
PI OXFORD
PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND
SN 1743-6095
J9 J SEX MED
JI J. Sex. Med.
PD JAN
PY 2007
VL 4
IS 1
BP 29
EP 37
DI 10.1111/j.1743-6109.2006.00395.x
PG 9
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Urology & Nephrology
GA 119PI
UT WOS:000243023900004
PM 17233774
DA 2025-06-11
ER

PT J
AU Shaaban, HH
   Alzaim, I
   El-Mallah, A
   Aly, RG
   El-Yazbi, AF
   Wahid, A
AF Shaaban, Hager H.
   Alzaim, Ibrahim
   El-Mallah, Ahmed
   Aly, Rania G.
   El-Yazbi, Ahmed F.
   Wahid, Ahmed
TI Metformin, pioglitazone, dapagliflozin and their combinations ameliorate
   manifestations associated with NAFLD in rats via anti-inflammatory,
   anti-fibrotic, anti-oxidant and anti-apoptotic mechanisms
SO LIFE SCIENCES
LA English
DT Article
DE NAFLD; Metabolic syndrome; Metformin; Pioglitazone; Dapagliflozin
ID NONALCOHOLIC FATTY LIVER; SELECTIVE INHIBITOR IPRAGLIFLOZIN; HEPATIC
   INSULIN-RESISTANCE; TYPE-2 DIABETES-MELLITUS; ACTIVATED PROTEIN-KINASE;
   TUMOR-NECROSIS-FACTOR; OXIDATIVE STRESS; GENE-EXPRESSION; VITAMIN-E;
   ENDOPLASMIC-RETICULUM
AB Non-alcoholic fatty liver disease (NAFLD) is an important health threat that is strongly linked to components of metabolic syndrome, particularly the low-grade inflammatory changes. Significantly, several of the available anti-diabetic drug classes demonstrate a considerable anti-inflammatory effect, and hence might be of benefit for NAFLD patients. In this study, we used a rat model of diet-induced NAFLD to examine the potential effect of metformin, pioglitazone, dapagliflozin and their combinations on NAFLD manifestations. Rats were fed an atherogenic diet containing 1.25 % cholesterol, 0.5 % cholic acid and 60 % cocoa butter for 6 weeks causing a number of metabolic and hepatic alterations including insulin resistance, dyslipidemia, systemic inflammation, increased hepatic oxidative stress and lipid peroxidation, hepatic steatosis, lobular inflammation, as well as increased markers of liver inflammation and hepatocyte apoptosis. Drug treatment, which started at the third week of NAFLD induction and continued for three weeks, not only ameliorated the observed metabolic impairment, but also functional and structural manifestations of NAFLD. Specifically, anti-diabetic drug treatment reversed markers of systemic and hepatic inflammation, oxidative stress, hepatic fibrosis, and hepatocyte apoptosis. Our findings propose that anti-diabetic drugs with a potential anti-inflammatory effect can ameliorate the manifestations of NAFLD, and thus may provide a therapeutic option for such a condition that is closely associated with metabolic diseases. The detailed pharmacology of these classes in aspects linked to the observed impact on NAFLD requires to be further investigated and translated into clinical studies for tailored therapy specifically targeting NAFLD.
C1 [Shaaban, Hager H.; El-Mallah, Ahmed; El-Yazbi, Ahmed F.] Alexandria Univ, Dept Pharmacol & Toxicol, Fac Pharm, Alexandria, Egypt.
   [Alzaim, Ibrahim] Amer Univ Beirut, Dept Biochem & Mol Genet, Fac Med, Beirut, Lebanon.
   [Alzaim, Ibrahim] Amer Univ Beirut, Dept Pharmacol & Toxicol, Fac Med, Beirut, Lebanon.
   [Aly, Rania G.] Alexandria Univ, Dept Pathol, Fac Med, Alexandria, Egypt.
   [El-Yazbi, Ahmed F.] Al Alamein Int Univ, Fac Pharm, Alamein, Egypt.
   [Wahid, Ahmed] Alexandria Univ, Dept Pharmaceut Biochem, Fac Pharm, Alexandria, Egypt.
C3 Egyptian Knowledge Bank (EKB); Alexandria University; American
   University of Beirut; American University of Beirut; Egyptian Knowledge
   Bank (EKB); Alexandria University; Alamein International University
   (AIU); Egyptian Knowledge Bank (EKB); Alexandria University
RP Shaaban, HH (corresponding author), Alexandria Univ, Dept Pharmacol & Toxicol, Fac Pharm, Alexandria, Egypt.; El-Yazbi, AF (corresponding author), Al Alamein Int Univ, Fac Pharm, Alamein, Egypt.; Wahid, A (corresponding author), Alexandria Univ, Dept Pharmaceut Biochem, Fac Pharm, Alexandria, Egypt.
EM hager.h.shaaban@alexu.edu.eg; Ahmed.fawzy.aly@alexu.edu.eg;
   ahmed.wahid@alexu.edu.eg
RI El-Yazbi, Ahmed/AAT-6837-2021; Gaber Aly, Rania/HGD-5586-2022; AlZaim,
   Ibrahim/IXD-6084-2023
OI El-Yazbi, Ahmed/0000-0003-3432-3038; Gaber, Rania/0000-0003-1227-6357;
   AlZaim, Ibrahim/0000-0001-6677-4365
FU Academic Thesis Research Fund (ATRF), Faculty of Pharmacy, Alexandria
   University
FX The research was funded by the Academic Thesis Research Fund (ATRF),
   Faculty of Pharmacy, Alexandria University
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NR 113
TC 22
Z9 23
U1 3
U2 20
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0024-3205
EI 1879-0631
J9 LIFE SCI
JI Life Sci.
PD NOV 1
PY 2022
VL 308
AR 120956
DI 10.1016/j.lfs.2022.120956
PG 14
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA 7Q6WX
UT WOS:000909530600001
PM 36103959
DA 2025-06-11
ER

PT J
AU Waye, MMY
AF Waye, Mary Miu Yee
TI New insights into how adenovirus might lead to obesity: An oxidative
   stress theory
SO FREE RADICAL RESEARCH
LA English
DT Review
DE Adenovirus 36; oxidation; metabolic syndrome; anti-oxidant; infection
ID SKELETAL-MUSCLE CELLS; IGF-I ACTIVITY; HELICOBACTER-PYLORI; GENE
   POLYMORPHISMS; GLUCOSE-UPTAKE; ASSOCIATION; INFECTION; RESVERATROL;
   ANTIOXIDANT; ADIPOSITY
AB Obesity has become a worldwide epidemic that leads to many serious weight-related disorders. Recently, infection by viruses has been proposed as a possible cause of the obesity epidemic. Of the many viruses screened, adenovirus 36 has been found to be a strong candidate virus that is associated with obesity, based on evidence in various model systems as well as clinical data. The mechanism of how the adenovirus could lead to obesity is not known and this paper proposes some new insights into how oxidative stress could be a possible mechanism of how adenovirus might lead to obesity. This paper reviews the relevant literature of both the effect of adenovirus on cells' anti-oxidant response and the link between obesity and oxidative stress.
C1 Chinese Univ Hong Kong, Croucher Lab Human Genom, Sch Biomed Sci, Shatin, Hong Kong, Peoples R China.
C3 Chinese University of Hong Kong
RP Waye, MMY (corresponding author), Chinese Univ Hong Kong, Croucher Lab Human Genom, Sch Biomed Sci, MMW Bldg,Rm 608, Shatin, Hong Kong, Peoples R China.
EM mary-waye@cuhk.edu.hk
RI 韋妙宜教授, Mary/A-9674-2008
OI Waye, Mary Miu Yee/0000-0002-2582-4917
FU Food and Health Bureau; Research Fund for the Control of Infectious
   Diseases of Hong Kong
FX The author wishes to thank the Food and Health Bureau and the Research
   Fund for the Control of Infectious Diseases of Hong Kong for financial
   Support. The author reports no conflicts of interest. The author alone
   is responsible for the content and writing of the paper.
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NR 70
TC 7
Z9 7
U1 1
U2 6
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1071-5762
EI 1029-2470
J9 FREE RADICAL RES
JI Free Radic. Res.
PD AUG
PY 2011
VL 45
IS 8
BP 880
EP 887
DI 10.3109/10715762.2011.571684
PG 8
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 790CJ
UT WOS:000292565800003
PM 21615271
DA 2025-06-11
ER

PT J
AU Kampoli, AM
   Tousoulis, D
   Briasoulis, A
   Latsios, G
   Papageorgiou, N
   Stefanadis, C
AF Kampoli, Anna-Maria
   Tousoulis, Dimitris
   Briasoulis, Alexandros
   Latsios, George
   Papageorgiou, Nikolaos
   Stefanadis, Christodoulos
TI Potential Pathogenic Inflammatory Mechanisms of Endothelial Dysfunction
   Induced by Type 2 Diabetes Mellitus
SO CURRENT PHARMACEUTICAL DESIGN
LA English
DT Review
DE Inflammation; diabetes mellitus; atherosclerosis
ID NITRIC-OXIDE SYNTHASE; C-REACTIVE PROTEIN; NECROSIS-FACTOR-ALPHA;
   ENDOPLASMIC-RETICULUM STRESS; INSULIN-RESISTANCE; MYOCARDIAL-INFARCTION;
   METABOLIC SYNDROME; OXIDATIVE STRESS; PROGENITOR CELLS; VITAMIN-C
AB Insulin resistance and the vascular complications of diabetes include activation of the inflammation cascade, endothelial dysfunction, and oxidative stress. The comorbidities of diabetes, namely obesity, insulin resistance, hyperglycemia, hypertension and dyslipidemia collectively aggravate these processes while antihyperglycemic interventions tend to correct them. Increased C-reactive protein, interleukin 6, tumor necrosis factor alpha and especially interstitial cellular adhesion molecule-1, vascular cellular adhesion molecule-1, and E-selectin are associated with cardiovascular and non-cardiovascular complications of both type 1 and type 2 diabetes. We sought to review the clinical implications of the inflammation theory, including the relevance of inflammation markers as predictors of type 2 diabetes in clinical studies, and the potential treatments of diabetes, inferred from the pathophysiology.
C1 [Kampoli, Anna-Maria; Tousoulis, Dimitris; Briasoulis, Alexandros; Latsios, George; Papageorgiou, Nikolaos; Stefanadis, Christodoulos] Univ Athens, Sch Med, Cardiol Unit 1, Hippokrat Hosp, GR-11527 Athens, Greece.
C3 National & Kapodistrian University of Athens; Hippokration General
   Hospital; Athens Medical School
RP Kampoli, AM (corresponding author), Univ Athens, Sch Med, Cardiol Unit 1, Hippokrat Hosp, GR-11527 Athens, Greece.
EM kampoliannamaria@yahoo.gr
RI PAPAGEORGIOU MD PhD, NIKOLAOS/AFV-3660-2022; Briasoulis,
   Alexandros/AAD-3965-2019; Stefanadis, Christodoulos/ABH-2232-2020
OI Briasoulis, Alexandros/0000-0002-5740-9670; Stefanadis,
   Christodoulos/0000-0001-5974-6454; Papageorgiou,
   Nikolaos/0000-0002-2063-2510
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NR 136
TC 67
Z9 72
U1 0
U2 9
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1381-6128
EI 1873-4286
J9 CURR PHARM DESIGN
JI Curr. Pharm. Design
PD DEC
PY 2011
VL 17
IS 37
BP 4147
EP 4158
DI 10.2174/138161211798764825
PG 12
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 941AX
UT WOS:000303935300006
PM 22204375
DA 2025-06-11
ER

PT J
AU Dube, L
   Spahis, S
   Lachaine, K
   Lemieux, A
   Monhem, H
   Poulin, SM
   Randoll, C
   Travaillaud, E
   Ould-Chikh, NE
   Marcil, V
   Delvin, E
   Levy, E
AF Dube, Laurent
   Spahis, Schohraya
   Lachaine, Karelle
   Lemieux, Andreanne
   Monhem, Hanine
   Poulin, Sarah-Maude
   Randoll, Carolane
   Travaillaud, Eva
   Ould-Chikh, Nour-El-Houda
   Marcil, Valerie
   Delvin, Edgard
   Levy, Emile
TI Specialized Pro-Resolving Mediators Derived from N-3 Polyunsaturated
   Fatty Acids: Role in Metabolic Syndrome and Related Complications
SO ANTIOXIDANTS & REDOX SIGNALING
LA English
DT Review
DE pro-resolving lipid mediators; fatty acids; metabolism; oxidative
   stress; inflammation; microbiota
ID INTESTINAL ALKALINE-PHOSPHATASE; ASPIRIN-TRIGGERED LIPOXINS; INDUCED
   INSULIN-RESISTANCE; CORD SYNAPTIC PLASTICITY; EICOSAPENTAENOIC ACID;
   LIPID MEDIATORS; MARESIN 1; DOCOSAHEXAENOIC ACID; OXIDATIVE STRESS;
   ANTIINFLAMMATORY ACTIONS
AB Significance: Metabolic syndrome (MetS) prevalence continues to grow and represents a serious public health issue worldwide. This multifactorial condition carries the risk of hastening the development of type 2 diabetes (T2D), non-alcoholic fatty liver disease (NAFLD), and cardiovascular diseases (CVD). Another troubling aspect of MetS is the requirement of poly-pharmacological therapy not devoid of side effects. Therefore, there is an urgent need for prospecting alternative nutraceuticals as effective therapeutic agents for MetS.Recent Advances: Currently, there is an increased interest in understanding the regulation of metabolic derangements by specialized pro-resolving lipid mediators (SPMs), especially those derived from the long chain n-3 polyunsaturated fatty acids.Critical Issues: The SPMs are recognized as efficient modulators that are capable of inhibiting the production of pro-inflammatory cytokines, blocking neutrophil activation/recruitment, and inducing non-phlogistic (anti-inflammatory) activation of macrophage engulfment and removal of apoptotic inflammatory cells and debris. The aim of the present review is precisely to first underline key concepts relative to SPM functions before focusing on their status and actions on MetS components (e.g., obesity, glucose dysmetabolism, hyperlipidemia, hypertension) and complications such as T2D, NAFLD, and CVD.Future Directions: Valuable data from preclinical and clinical investigations have emphasized the SPM functions and influence on oxidative stress- and inflammation-related MetS. Despite these promising findings obtained without compromising host defense, additional efforts are needed to evaluate their potential therapeutic applications and further develop practical tools to monitor their bioavailability to cope with cardiometabolic disorders. Antioxid. Redox Signal. 37, 54-83.
C1 [Dube, Laurent; Spahis, Schohraya; Ould-Chikh, Nour-El-Houda; Marcil, Valerie; Delvin, Edgard; Levy, Emile] Univ Montreal, St Justine Hosp, Res Ctr, Montreal, PQ, Canada.
   [Dube, Laurent; Spahis, Schohraya; Lachaine, Karelle; Lemieux, Andreanne; Monhem, Hanine; Poulin, Sarah-Maude; Randoll, Carolane; Travaillaud, Eva; Marcil, Valerie; Levy, Emile] Univ Montreal, Dept Nutr, Montreal, PQ, Canada.
   [Spahis, Schohraya; Marcil, Valerie; Levy, Emile] Laval Univ, Inst Nutr & Funct Foods, Quebec City, PQ, Canada.
   [Delvin, Edgard] Univ Montreal, Dept Biochem, Montreal, PQ, Canada.
   [Levy, Emile] Univ Montreal, Dept Pediat, Gastroenterol & Hepatol Unit, Montreal, PQ, Canada.
   [Levy, Emile] Univ Montreal, St Justine Hosp, Res Ctr, 3175 Ste Catherine Rd,4-17-005, Montreal, PQ H3T 1C5, Canada.
C3 Universite de Montreal; Centre Hospitalier Universitaire Sainte-Justine;
   Universite de Montreal; Laval University; Universite de Montreal;
   Universite de Montreal; Universite de Montreal; Centre Hospitalier
   Universitaire Sainte-Justine
RP Levy, E (corresponding author), Univ Montreal, St Justine Hosp, Res Ctr, 3175 Ste Catherine Rd,4-17-005, Montreal, PQ H3T 1C5, Canada.
EM emile.levy.hsj@ssss.gouv.qc.ca
OI Spahis, Schohraya/0000-0003-4130-4994
FU J. A. DeSe`ve Research Chair in Nutrition
FX This study was supported by the J. A. DeSe`ve Research Chair in
   Nutrition.
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NR 214
TC 7
Z9 7
U1 3
U2 11
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1523-0864
EI 1557-7716
J9 ANTIOXID REDOX SIGN
JI Antioxid. Redox Signal.
PD JUL 1
PY 2022
VL 37
IS 1-3
BP 54
EP 83
DI 10.1089/ars.2021.0156
PG 30
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 2U1SW
UT WOS:000822943600004
PM 35072542
DA 2025-06-11
ER

PT J
AU Cahova, M
   Chrastina, P
   Hansikova, H
   Drahota, Z
   Trnovska, J
   Skop, V
   Spacilova, J
   Malinska, H
   Oliyarnyk, O
   Papackova, Z
   Palenickova, E
   Kazdova, L
AF Cahova, Monika
   Chrastina, Petr
   Hansikova, Hana
   Drahota, Zdenek
   Trnovska, Jaroslava
   Skop, Vojtech
   Spacilova, Jana
   Malinska, Hana
   Oliyarnyk, Olena
   Papackova, Zuzana
   Palenickova, Eliska
   Kazdova, Ludmila
TI Carnitine supplementation alleviates lipid metabolism derangements and
   protects against oxidative stress in non-obese hereditary
   hypertriglyceridemic rats
SO APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
LA English
DT Article
DE metabolic syndrome; insulin resistance; antioxidant; liver steatosis;
   mass spectrometry
ID INSULIN SENSITIVITY; ANTIOXIDANT; RESISTANCE; PRODUCTS; PROFILE; WEIGHT
AB The aim of this study was to estimate the effect of carnitine supplementation on lipid disorders and peripheral tissue insulin sensitivity in a non-obese animal model of insulin resistance, the hereditary hypertriglyceridemic (HHTg) rat. Male HHTg rats were fed a standard diet, and half of them received daily doses of carnitine (500 mg.kg(-1) body weight) for 8 weeks. Rats of the original Wistar strain were used for comparison. HHTg rats exhibited increased urinary excretion of free carnitine and reduced carnitine content in the liver and blood. Carnitine supplementation compensated for this shortage and promoted urinary excretion of acetylcarnitine without any signs of (acyl) carnitine accumulation in skeletal muscle. Compared with their untreated littermates, carnitine-treated HHTg rats exhibited lower weight gain, reduced liver steatosis, lower fasting triglyceridemia, and greater reduction of serum free fatty acid content after glucose load. Carnitine treatment was associated with increased mitochondrial biogenesis and oxidative capacity for fatty acids, amelioration of oxidative stress, and restored substrate switching in the liver. In skeletal muscle (diaphragm), carnitine supplementation was associated with significantly higher palmitate oxidation and a more favorable complete to incomplete oxidation products ratio. Carnitine supplementation further enhanced insulin sensitivity ex vivo. No effects on whole-body glucose tolerance were observed. Our data suggest that some metabolic syndrome-related disorders, particularly fatty acid oxidation, steatosis, and oxidative stress in the liver, could be attenuated by carnitine supplementation. The effect of carnitine could be explained, at least partly, by enhanced substrate oxidation and increased fatty acid transport from tissues in the form of short-chain acylcarnitines.
C1 [Cahova, Monika; Trnovska, Jaroslava; Skop, Vojtech; Malinska, Hana; Oliyarnyk, Olena; Papackova, Zuzana; Palenickova, Eliska; Kazdova, Ludmila] Inst Clin & Expt Med, Ctr Med Expt, Videnska 1958-9, Prague 4, Czech Republic.
   [Chrastina, Petr] Charles Univ Prague, Fac Med 1, Inst Inherited Metab Disorders, Prague 2, Czech Republic.
   [Chrastina, Petr; Hansikova, Hana; Trnovska, Jaroslava] Gen Univ Hosp Prague, Prague 2, Czech Republic.
   [Hansikova, Hana; Spacilova, Jana] Charles Univ Prague, Fac Med 1, Dept Pediat & Adolescent Med, Prague, Czech Republic.
   [Drahota, Zdenek] Acad Sci Czech Republ, Inst Physiol, Prague 4, Czech Republic.
   [Skop, Vojtech] Inst Chem Technol, Dept Biochem & Microbiol, CR-16628 Prague, Czech Republic.
   [Palenickova, Eliska] Charles Univ Prague, Fac Sci, Dept Cell Biol, Prague 2, Czech Republic.
C3 Institute for Clinical & Experimental Medicine (IKEM); Charles
   University Prague; General University Hospital Prague; Charles
   University Prague; Czech Academy of Sciences; Institute of Physiology of
   the Czech Academy of Sciences; University of Chemistry & Technology,
   Prague; Charles University Prague
RP Cahova, M (corresponding author), Inst Clin & Expt Med, Ctr Med Expt, Videnska 1958-9, Prague 4, Czech Republic.
EM monika.cahova@ikem.cz
RI Oliyarnyk, Olena/Q-6380-2019; Cahova, Monika/Z-1568-2018; Drahota,
   Zdenek/F-8296-2014; Krizova, Jana/E-8721-2017; Chrastina,
   Petr/K-8981-2017; Hansikova, Hana/E-9350-2017; Skop,
   Vojtech/LBI-2231-2024
OI Drahota, Zdenek/0000-0003-2117-6809; Cahova, Monika/0000-0003-2640-5084;
   Trnovska, Jaroslava/0000-0001-6468-8244; Krizova,
   Jana/0000-0003-1841-7341; Chrastina, Petr/0000-0003-4404-6513;
   Hansikova, Hana/0000-0002-2734-225X; Skop, Vojtech/0000-0002-4685-4429;
   Oliyarnyk, Olena/0000-0002-4912-6187
FU MH CR-DRO ("Institute for Clinical and Experimental Medicine - IKEM) [IN
   00023001]; MH CZ-DRO VFN [64165]; ERC CZ program [LL 1204]; Grant Agency
   of the Czech Republic [14-36804G]
FX This study was supported by MH CR-DRO ("Institute for Clinical and
   Experimental Medicine - IKEM, IN 00023001"), MH CZ-DRO VFN 64165, grant
   No. LL 1204 (within the ERC CZ program), and project 14-36804G from the
   Grant Agency of the Czech Republic.
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NR 40
TC 16
Z9 19
U1 1
U2 23
PU CANADIAN SCIENCE PUBLISHING
PI OTTAWA
PA 65 AURIGA DR, SUITE 203, OTTAWA, ON K2E 7W6, CANADA
SN 1715-5312
EI 1715-5320
J9 APPL PHYSIOL NUTR ME
JI Appl. Physiol. Nutr. Metab.
PD MAR
PY 2015
VL 40
IS 3
BP 280
EP 291
DI 10.1139/apnm-2014-0163
PG 12
WC Nutrition & Dietetics; Physiology; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics; Physiology; Sport Sciences
GA CE6LX
UT WOS:000351949000011
PM 25723909
DA 2025-06-11
ER

PT J
AU Sun, J
   Jin, XL
   Li, YL
AF Sun, Jing
   Jin, Xiuli
   Li, Yiling
TI Current strategies for nonalcoholic fatty liver disease treatment
   (Review)
SO INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
LA English
DT Review
DE NAFLD; NASH; insulin resistance; oxidative stress; inflammation; lipid
   accumulation
ID ENDOPLASMIC-RETICULUM STRESS; HEPATIC LIPID-ACCUMULATION; VITAMIN-D;
   METABOLIC SYNDROME; DOUBLE-BLIND; INSULIN-RESISTANCE; OXIDATIVE STRESS;
   GUT MICROBIOTA; UP-REGULATION; SYNBIOTIC SUPPLEMENTATION
AB Nonalcoholic fatty liver disease (NAFLD), the most common chronic hepatic disease, has become a leading health problem worldwide. The present review summarized the methods and mechanisms to treat NAFLD, including the Mediterranean diet, physical activity and exercise, bariatric surgery and specific therapeutic agents, including statins, peroxisome proliferator-activated receptor agonists, cenicriviroc and farnesoid X receptor agonists. Biologically active substances, such as peptides, alkaloids, polyphenolic compounds, silymarin, antibiotics, fatty acids, vitamins, probiotics, synbiotics and lamiaceae have also demonstrated actions that combat NAFLD. Considering their different mechanisms of action, combining some of them may prove an efficacious treatment for NAFLD. In this light, the present review describes recent progress and future prospects in treating NAFLD.
C1 [Sun, Jing; Jin, Xiuli; Li, Yiling] China Med Univ, Dept Gastroenterol, Hosp 1, 155 Nanjing North St, Shenyang 110002, Liaoning, Peoples R China.
C3 China Medical University
RP Li, YL (corresponding author), China Med Univ, Dept Gastroenterol, Hosp 1, 155 Nanjing North St, Shenyang 110002, Liaoning, Peoples R China.
EM lyl-72@163.com
RI Li, Yiling/HGF-0094-2022
FU General Program of Educational Department of Liaoning Province
FX Not applicable.
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NR 231
TC 4
Z9 4
U1 8
U2 21
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1107-3756
EI 1791-244X
J9 INT J MOL MED
JI Int. J. Mol. Med.
PD OCT
PY 2024
VL 54
IS 4
AR 88
DI 10.3892/ijmm.2024.5412
PG 15
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA D3X1E
UT WOS:001295538200001
PM 39129305
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Remels, AH
   Gosker, HR
   Schrauwen, P
   Langen, RC
   Schols, AM
AF Remels, A. H.
   Gosker, H. R.
   Schrauwen, P.
   Langen, R. C.
   Schols, A. M.
TI Peroxisome proliferator-activated receptors: a therapeutic target in
   COPD?
SO EUROPEAN RESPIRATORY JOURNAL
LA English
DT Article
DE chronic obstructive pulmonary disease; inflammation; oxidative stress;
   peroxisome proliferator-activated receptors; skeletal muscle
ID OBSTRUCTIVE PULMONARY-DISEASE; NF-KAPPA-B; FATTY-ACID CATABOLISM; DELTA
   PPAR-DELTA; SKELETAL-MUSCLE; NITRIC-OXIDE; OXIDATIVE STRESS; METABOLIC
   SYNDROME; INFLAMMATORY RESPONSES; ALPHA ACTIVATION
AB Extrapulmonary pathology significantly impairs clinical outcome in chronic obstructive pulmonary disease (COPD).
   The peroxisome proliferator-activated receptors (PPARs) are implicated in the regulation of several hallmarks of systemic COPD pathology, including cachexia, decreased oxidative muscle metabolism, oxidative stress and systemic inflammation.
   Recently, expression of PPARs and related cofactors was shown to be reduced in peripheral skeletal muscle of patients with moderate-to-severe COPD and muscle weakness.
   The current authors hypothesise that impaired peroxisome proliferator-activated receptor signalling may underlie some of the muscular disturbances in chronic obstructive pulmonary disease. Proposed mechanisms will be outlined in the present article, as well as the therapeutic potential of peroxisome proliferator-activated receptor modulation in the treatment of skeletal muscle dysfunction.
C1 [Remels, A. H.; Gosker, H. R.; Langen, R. C.; Schols, A. M.] Univ Maastricht, Dept Resp Med, NUTRIM Sch Nutr Toxicol & Metab, NL-6202 AZ Maastricht, Netherlands.
   [Schrauwen, P.] Univ Maastricht, Dept Human Biol, NUTRIM Sch Nutr Toxicol & Metab, NL-6202 AZ Maastricht, Netherlands.
C3 Maastricht University; Maastricht University Medical Centre (MUMC);
   Maastricht University; Maastricht University Medical Centre (MUMC)
RP Remels, AH (corresponding author), Univ Maastricht, Dept Resp Med, NUTRIM Sch Nutr Toxicol & Metab, POB 5800, NL-6202 AZ Maastricht, Netherlands.
EM a.remels@pul.unimaas.nl
RI Remels, Alexander/NBX-8148-2025; schrauwen, patrick/KRR-1274-2024
OI Gosker, Harry/0000-0002-7659-0225; schrauwen,
   patrick/0000-0002-0973-847X
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NR 78
TC 34
Z9 38
U1 0
U2 7
PU EUROPEAN RESPIRATORY SOC JOURNALS LTD
PI SHEFFIELD
PA 442 GLOSSOP RD, SHEFFIELD S10 2PX, ENGLAND
SN 0903-1936
EI 1399-3003
J9 EUR RESPIR J
JI Eur. Resp. J.
PD MAR
PY 2008
VL 31
IS 3
BP 502
EP 508
DI 10.1183/09031936.00068207
PG 7
WC Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Respiratory System
GA 272RA
UT WOS:000253876000005
PM 18310397
OA Bronze, Green Submitted
DA 2025-06-11
ER

PT J
AU Mahmoud, AAA
   Elshazly, SM
AF Mahmoud, Amr A. A.
   Elshazly, Shimaa M.
TI Ursodeoxycholic Acid Ameliorates Fructose-Induced Metabolic Syndrome in
   Rats
SO PLOS ONE
LA English
DT Article
ID IMPROVES INSULIN SENSITIVITY; CORONARY-HEART-DISEASE; FATTY
   LIVER-DISEASE; ENDOTHELIAL DYSFUNCTION; NITRIC-OXIDE; HYPERTENSIVE-RATS;
   DIETARY FRUCTOSE; OXIDATIVE STRESS; RESISTANCE; FENOFIBRATE
AB The metabolic syndrome (MS) is characterized by insulin resistance, dyslipidemia and hypertension. It is associated with increased risk of cardiovascular diseases and type-2 diabetes. Consumption of fructose is linked to increased prevalence of MS. Ursodeoxycholic acid (UDCA) is a steroid bile acid with antioxidant, anti-inflammatory activities and has been shown to improve insulin resistance. The current study aims to investigate the effect of UDCA (150 mg/kg) on MS induced in rats by fructose administration (10%) in drinking water for 12 weeks. The effects of UDCA were compared to fenofibrate (100 mg/kg), an agonist of PPAR-a receptors. Treatment with UDCA or fenofibrate started from the 6 th week after fructose administration once daily. Fructose administration resulted in significant increase in body weight, elevations of blood glucose, serum insulin, cholesterol, triglycerides, advanced glycation end products (AGEs), uric acid levels, insulin resistance index and blood pressure compared to control rats. Moreover, fructose increased oxidative stress in aortic tissues indicated by significant increases of malondialdehyde (MDA), expression of iNOS and reduction of reduced glutathione (GSH) content. These disturbances were associated with decreased eNOS expression, increased infiltration of leukocytes and loss of aortic vascular elasticity. Treatment with UDCA successfully ameliorated the deleterious effects of fructose. The protective effect of UDCA could be attributed to its ability to decrease uric acid level, improve insulin resistance and diminish oxidative stress in vascular tissues. These results might support possible clinical application of UDCA in MS patients especially those present with liver diseases, taking into account its tolerability and safety. However, further investigations on human subjects are needed before the clinical application of UDCA for this indication.
C1 [Mahmoud, Amr A. A.; Elshazly, Shimaa M.] Zagazig Univ, Fac Pharm, Dept Pharmacol, Zagazig, Egypt.
C3 Egyptian Knowledge Bank (EKB); Zagazig University
RP Elshazly, SM (corresponding author), Zagazig Univ, Fac Pharm, Dept Pharmacol, Zagazig, Egypt.
EM shimaa_elshazly@yahoo.com
RI Mahmoud, Amr/Y-7062-2019
OI Mahmoud, Amr/0000-0003-2959-0692
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TC 55
Z9 58
U1 0
U2 7
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD SEP 9
PY 2014
VL 9
IS 9
AR e106993
DI 10.1371/journal.pone.0106993
PG 8
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA AQ3IF
UT WOS:000342684500059
PM 25202970
OA Green Published, Green Submitted, gold, Green Accepted
DA 2025-06-11
ER

PT J
AU Bourebaba, L
   Bedjou, F
   Röcken, M
   Marycz, K
AF Bourebaba, Lynda
   Bedjou, Fatiha
   Roecken, Michael
   Marycz, Krzysztof
TI Nortropane alkaloids as pharmacological chaperones in the rescue of
   equine adipose-derived mesenchymal stromal stem cells affected by
   metabolic syndrome through mitochondrial potentiation, endoplasmic
   reticulum stress mitigation and insulin resistance alleviation
SO STEM CELL RESEARCH & THERAPY
LA English
DT Article
DE EMS; ASCs; Hyoscyamus albus; Calystegines; Iminosugars; Insulin
   resistance
ID OXIDATIVE STRESS; GENE-EXPRESSION; CALYSTEGINES; APOPTOSIS; AUTOPHAGY;
   DIFFERENTIATION; DYSFUNCTION; IMINOSUGARS; INHIBITION; MECHANISMS
AB ObjectivesEquine metabolic syndrome (EMS) refers to a cluster of associated abnormalities and metabolic disorders, including insulin resistance and adiposity. The numerous biological properties of mesenchymal stem cells (MSCs), including self-renewal and multipotency, have been the subject of many in-depth studies, for the management of EMS; however, it has been shown that this cell type may be affected by the condition, impairing thus seriously their therapeutic potential. Therefore, an attempt to rescue EMS adipose-derived stem cells (ASCs) with calystegines (polyhydroxylated alkaloids) that are endowed with strong antioxidant and antidiabetic abilities was performed.MethodsASCs isolated from EMS horses were subsequently treated with various concentrations of total calystegines. Different parameters were then assessed using flow cytometry, confocal as well as SE microscopy, and RT-qPCR.ResultsOur results clearly demonstrated that calystegines could improve EqASC viability and proliferation and significantly reduce apoptosis, via improvement of mitochondrial potentiation and functionality, regulation of pro- and anti-apoptotic pathways, and suppression of ER stress. Furthermore, nortropanes positively upregulated GLUT4 and IRS transcripts, indicating a possible sensitizing or mimetic effect to insulin. Most interesting finding in this investigation lies in the modulatory effect of autophagy, a process that allows the maintenance of cellular homeostasis; calystegines acted as pharmacological chaperones to promote cell survival.ConclusionObtained data open new perspectives in the development of new drugs, which may improve the metabolic dynamics of cells challenged by MS.
C1 [Bourebaba, Lynda; Marycz, Krzysztof] Wroclaw Univ Environm & Life Sci, Fac Biol & Anim Sci, Dept Expt Biol, Norwida 27B, PL-50375 Wroclaw, Poland.
   [Roecken, Michael; Marycz, Krzysztof] Justus Liebig Univ, Equine Clin Equine Surg, Fac Vet Med, D-35392 Giessen, Germany.
   [Bedjou, Fatiha] Univ Bejaia, Fac Sci Nat & Vie, Lab Biotechnol Vegetales & Ethnobot, Bejaia, Algeria.
   [Bourebaba, Lynda; Marycz, Krzysztof] Int Inst Translat Med, Jesionowa 11, PL-55114 Malin, Wisznia Mala, Poland.
C3 Wroclaw University of Environmental & Life Sciences; Justus Liebig
   University Giessen; Universite de Bejaia
RP Bourebaba, L; Marycz, K (corresponding author), Wroclaw Univ Environm & Life Sci, Fac Biol & Anim Sci, Dept Expt Biol, Norwida 27B, PL-50375 Wroclaw, Poland.; Marycz, K (corresponding author), Justus Liebig Univ, Equine Clin Equine Surg, Fac Vet Med, D-35392 Giessen, Germany.; Bourebaba, L; Marycz, K (corresponding author), Int Inst Translat Med, Jesionowa 11, PL-55114 Malin, Wisznia Mala, Poland.
EM lynda.bourebaba@upwr.edu.pl; krzysztof.marycz@upwr.edu.pl
RI Bourebaba, Lynda/AAX-7613-2020
FU National Science Centre in Poland [2016/21/B/NZ7/01111]
FX This project is financed in the framework of the grant entitled
   "Modulation mitochondrial metabolism and dynamics and targeting DNA
   methylation of adipose-derived mesenchymal stromal stem cell (ASC) using
   RES and 5-azacytydin as a therapeutic strategy in the course of EMS"
   (grant no. 2016/21/B/NZ7/01111) attributed by The National Science
   Centre in Poland.
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NR 66
TC 12
Z9 13
U1 0
U2 5
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1757-6512
J9 STEM CELL RES THER
JI Stem Cell Res. Ther.
PD JUN 18
PY 2019
VL 10
AR 178
DI 10.1186/s13287-019-1292-z
PG 20
WC Cell & Tissue Engineering; Cell Biology; Medicine, Research &
   Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Research & Experimental Medicine
GA IE0YP
UT WOS:000472113100003
PM 31215461
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Merhi, Z
   Kandaraki, EA
   Diamanti-Kandarakis, E
AF Merhi, Zaher
   Kandaraki, Eleni A.
   Diamanti-Kandarakis, Evanthia
TI Implications and Future Perspectives of AGEs in PCOS Pathophysiology
SO TRENDS IN ENDOCRINOLOGY AND METABOLISM
LA English
DT Review
ID GLYCATION END-PRODUCTS; POLYCYSTIC-OVARY-SYNDROME; ANTI-MULLERIAN
   HORMONE; DIETARY GLYCOTOXINS; CARDIOVASCULAR-DISEASE; OXIDATIVE STRESS;
   GRANULOSA-CELLS; METABOLIC SYNDROME; FOLLICULAR-FLUID; RECEPTOR
AB Human, animal, and in vitro studies provide evidence that advanced glycation end-products (AGEs) may contribute to the pathogenesis of polycystic ovary syndrome (PCOS) and its metabolic and reproductive consequences. AGEs are able to induce, via activation of key intracellular signaling pathways, the generation of oxidative stress and proinflammatory cytokines, thus contributing to the adverse health impact of PCOS. This review presents the implications of AGEs in several disease pathophysiologies, including PCOS, as well as the cellular and systemic effects of AGEs on insulin resistance (IR), hyperandrogenemia, endoplasmic reticulum (ER) stress, hypoxia, and ovarian function. The gaps in our knowledge will serve as launching pad for future developments ranging from dietary and lifestyle changes to pharmaceutical interventions aiming at potential applications in women with PCOS.
C1 [Merhi, Zaher] NYU, Dept Obstet & Gynecol, Sch Med, New York, NY 10016 USA.
   [Merhi, Zaher] Albert Einstein Coll Med, Dept Biochem, Bronx, NY 10467 USA.
   [Kandaraki, Eleni A.] St Bartholomews Hosp, Dept Endocrinol, London EC1A 7BE, England.
   [Diamanti-Kandarakis, Evanthia] Univ Athens, Sch Med, GR-11527 Athens, Greece.
   [Diamanti-Kandarakis, Evanthia] Hygeia Hosp, Endocrinol & Diabet Dept, Athens 15123, Greece.
C3 New York University; Montefiore Medical Center; Albert Einstein College
   of Medicine; Yeshiva University; University of London; Queen Mary
   University London; Athens Medical School; National & Kapodistrian
   University of Athens; Hygeia Hospital
RP Merhi, Z (corresponding author), NYU, Dept Obstet & Gynecol, Sch Med, New York, NY 10016 USA.; Merhi, Z (corresponding author), Albert Einstein Coll Med, Dept Biochem, Bronx, NY 10467 USA.
EM zom00@hotmail.com
FU American Society for Reproductive Medicine (ASRM)
FX This work was funded by a grant from the American Society for
   Reproductive Medicine (ASRM) to Z.M.
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NR 97
TC 47
Z9 49
U1 0
U2 33
PU ELSEVIER SCIENCE LONDON
PI LONDON
PA 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND
SN 1043-2760
EI 1879-3061
J9 TRENDS ENDOCRIN MET
JI Trends Endocrinol. Metab.
PD MAR
PY 2019
VL 30
IS 3
BP 150
EP 162
DI 10.1016/j.tem.2019.01.005
PG 13
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA HM0HR
UT WOS:000459128600003
PM 30712978
DA 2025-06-11
ER

PT J
AU Ndrepepa, G
   Colleran, R
   Kastrati, A
AF Ndrepepa, Gjin
   Colleran, Roisin
   Kastrati, Adnan
TI Gamma-glutamyl transferase and the risk of atherosclerosis and coronary
   heart disease
SO CLINICA CHIMICA ACTA
LA English
DT Review
DE Atherosclerosis; Coronary heart disease; Gamma-glutamyl transferase;
   Mortality
ID FATTY LIVER-DISEASE; CHRONIC KIDNEY-DISEASE; ELEVATION
   MYOCARDIAL-INFARCTION; HEPATIC INSULIN-RESISTANCE; YOUNG-ADULTS CARDIA;
   CARDIOVASCULAR-DISEASE; ALCOHOL-CONSUMPTION; OXIDATIVE STRESS; ARTERY
   CALCIFICATION; METABOLIC SYNDROME
AB Gamma-glutamyl transferase (GGT) is a ubiquitous cell surface enzyme that cleaves extracellular glutathione (G-SH) or other gamma-glutamyl compounds. GGT serves to increase the availability of amino acids, primarily cysteine, for intracellular G-SH synthesis and plays a crucial role in maintaining G-SH homeostasis and defense against oxidative stress in organisms. Measurement of circulating GGT activity is widely used for the diagnosis of liver and obstructive biliary diseases and as an indicator of alcohol consumption. Epidemiological studies suggest an association between elevated GGT activity level and a risk of incident coronary heart disease (CHD) or CHD-related mortality. Elevated GGT activity level is associated with a plethora of cardio-metabolic risk factors, including traditional cardiovascular risk factors, metabolic syndrome, systemic inflammation, oxidative stress burden and various comorbidities that incur a negative impact on patient risk profile and prognosis. Experimental studies and studies of human atherosclerotic plaques have revealed not only the presence of catalytically active GGT in atherosclerotic plaques, but also a correlation between GGT activity and indices of plaque instability, suggesting direct involvement in the pathophysiology of atherosclerosis and related clinical events via promotion of pro-oxidant reactions by the enzyme. However, it remains unknown whether GGT plays a direct role in the pathophysiology of atherosclerosis and CHD or is merely a correlate of coexisting cardiovascular risk factors. The exact molecular mechanisms of GGT participation in atherosclerosis or CHD and assessment of GGT-lowering therapies, as well as their impact on clinical outcomes, remain to be investigated in longitudinal studies.
C1 [Ndrepepa, Gjin; Colleran, Roisin; Kastrati, Adnan] Tech Univ Munich, Deutsch Herzzentrum Munchen, Dept Adult Cardiol, Munich, Germany.
   [Kastrati, Adnan] DZHK German Ctr Cardiovasc Res, Partner Site Munich Heart Alliance, Munich, Germany.
C3 Technical University of Munich; German Heart Centre Munich; German
   Centre for Cardiovascular Research; Munich Heart Alliance
RP Ndrepepa, G (corresponding author), Deutsch Herzzentrum Munich, Lazarettstr 36, D-80636 Munich, Germany.
EM ndrepepa@dhm.mhn.de
RI , Kastrati/Y-2389-2019
OI Colleran, Roisin/0000-0002-9603-9502
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NR 127
TC 124
Z9 130
U1 1
U2 27
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0009-8981
EI 1873-3492
J9 CLIN CHIM ACTA
JI Clin. Chim. Acta
PD JAN
PY 2018
VL 476
BP 130
EP 138
DI 10.1016/j.cca.2017.11.026
PG 9
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA FT2WN
UT WOS:000423006800021
PM 29175647
DA 2025-06-11
ER

PT J
AU Palanisamy, N
   Viswanathan, P
   Ravichandran, MK
   Anuradha, CV
AF Palanisamy, Nallasamy
   Viswanathan, Periyasamy
   Ravichandran, Mambakkam Katchapeswaran
   Anuradha, Carani Venkataraman
TI Renoprotective and blood pressure-lowering effect of dietary soy protein
   via protein kinase C βII inhibition in a rat model of metabolic syndrome
SO CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
LA English
DT Article
DE blood pressure; casein; protein kinase C beta II; fructose; soy protein;
   kinins; nitric oxide
ID ANGIOTENSIN-CONVERTING-ENZYME; FRUCTOSE-INDUCED HYPERTENSION; URINARY
   ALBUMIN EXCRETION; INSULIN-RESISTANCE; NITRIC-OXIDE;
   DIABETIC-NEPHROPATHY; GLOMERULAR INJURY; OXIDATIVE STRESS; LIPID
   PROFILE; L-CARNITINE
AB We studied whether substitution of soy protein for casein (an improve insulin sensitivity, lower blood pressure (BP), and inhibit protein kinase C beta II (PKC beta II) activation in kidney in an acquired model of metabolic syndrome. Adult male rats were fed 4 different diets: (i) starch (60%) and casein (200/v) (CCD), (ii) fructose (60%) and casein (20%) (FCD), (iii) fructose (60%) and soy protein (20%) (FSD), and (iv) starch (60%) and soy protein (20%) (CSD). Renal function parameters, BP, pressor mechanisms, PKC beta II expression, oxidative stress, and renal histology were evaluated after 60 days. FCD rats displayed insulin resistance and significant changes in body weight, kidney weight, urine volume, plasma and urine electrolytes accompanied by significant changes in renal function parameters compared with CCD rats. Elevated BP, plasma angiotensin-converting enzyme (ACE) activity, renal oxidative stress, and reduced nitrite (NO) and kallikrein activity were observed. Western blot analysis revealed enhanced renal expression of membrane-associated PKC beta II in the FCD group. Histology showed fatty infiltration and thickening of glomeruli while urinary protein profile revealed a 5-fold increase in albumin. Substitution of soy protein for casein improved insulin sensitivity, lowered BP and PKC beta II activation and restored renal function. Antioxidant action, inhibitory effect on ACE and PKC beta II activation, and increased availability of kinins and NO could be contributing mechanisms for the benefits of dietary soy protein.
C1 [Palanisamy, Nallasamy; Anuradha, Carani Venkataraman] Annamalai Univ, Fac Sci, Dept Biochem & Biotechnol, Annamalainagar 608002, Tamil Nadu, India.
   [Viswanathan, Periyasamy] Annamalai Univ, Dept Pathol, Fac Med, Rajah Muthaih Med Coll, Annamalainagar 608002, Tamil Nadu, India.
   [Ravichandran, Mambakkam Katchapeswaran] Annamalai Univ, Fac Sci, Dept Stat, Annamalainagar 608002, Tamil Nadu, India.
C3 Annamalai University; Annamalai University; Annamalai University
RP Anuradha, CV (corresponding author), Annamalai Univ, Fac Sci, Dept Biochem & Biotechnol, Annamalainagar 608002, Tamil Nadu, India.
EM cvaradha@hotmail.com
RI Venkatraman, Anuradha/U-8717-2019; Nallasamy, Palanisamy/AAH-7727-2021
OI NALLASAMY, PALANISAMY/0000-0001-8962-2487
FU Indian Council of Medical Research (ICMR), New Delhi
FX The financial support in the form of a Senior Research Fellowship to Mr.
   N. Palanisamy from the Indian Council of Medical Research (ICMR), New
   Delhi, is gratefully acknowledged. The authors thank Mr. M. Manikam,
   Managing Director, Sakthi Suvars Pvt. Ltd., a division of Sakthi Soya
   Pvt. Ltd., Coimbatore, India, for providing soy protein concentrate.
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NR 49
TC 13
Z9 16
U1 0
U2 6
PU CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS
PI OTTAWA
PA 65 AURIGA DR, SUITE 203, OTTAWA, ON K2E 7W6, CANADA
SN 0008-4212
EI 1205-7541
J9 CAN J PHYSIOL PHARM
JI Can. J. Physiol. Pharmacol.
PD JAN
PY 2010
VL 88
IS 1
BP 28
EP 37
DI 10.1139/Y09-110
PG 10
WC Pharmacology & Pharmacy; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Physiology
GA 565FE
UT WOS:000275273800005
PM 20130736
DA 2025-06-11
ER

PT J
AU Sharkey, D
   Gardner, DS
   Fainberg, HP
   Sébert, S
   Bos, P
   Wilson, V
   Bell, R
   Symonds, ME
   Budge, H
AF Sharkey, Don
   Gardner, David S.
   Fainberg, Hernan P.
   Sebert, Sylvain
   Bos, Petra
   Wilson, Vicky
   Bell, Rhonda
   Symonds, Michael E.
   Budge, Helen
TI Maternal nutrient restriction during pregnancy differentially alters the
   unfolded protein response in adipose and renal tissue of obese juvenile
   offspring
SO FASEB JOURNAL
LA English
DT Article
DE endoplasmic reticulum; inflammation; fetus; metabolic syndrome
ID ENDOPLASMIC-RETICULUM STRESS; METABOLIC SYNDROME; DEVELOPMENTAL ORIGINS;
   MACROPHAGE INFILTRATION; GLUCOSE-HOMEOSTASIS; ADIPOCYTE DEATH;
   KIDNEY-DISEASE; ER STRESS; EXPRESSION; DIET
AB Maternal diet during pregnancy can program an offspring's risk of disease in later life. Obesity adversely alters renal and adipose tissue function, resulting in chronic kidney disease and insulin resistance, respectively, the latter associated with dysregulation of the unfolded protein response (UPR). In view of the current obesity epidemic, we explored the combined effects of in utero early-to midgestational nutrient restriction and postnatal obesity on the UPR in ovine juvenile offspring. Nutrient restriction was coincident with fetal kidney development but prior to exponential adipose tissue deposition. Nutrient restricted (NR) and normal diet (control) offspring were exposed to an obesogenic environment throughout adolescence, resulting in similar degrees of juvenile obesity. NR offspring showed enhanced adipose tissue dysregulation characterized by activation of the UPR, perturbed insulin signaling, and marked inflammation, as demonstrated by increased abundance of crownlike structures and proinflammatory genes. Conversely, in renal tissue NR offspring had marked attenuation of cellular stress and inflammation evident as reduced activation of the UPR, down-regulation of proinflammatory genes, and less histological damage. In conclusion, obesity-related activation of the UPR can be determined by the in utero nutritional environment, demonstrating organ-specific effects dependent on the developmental phase targeted within the fetus.-Sharkey, D., Gardner, D. S., Fainberg, H. P., Sebert, S., Bos, P., Wilson, V., Bell, R., Symonds, M. E., Budge, H. Maternal nutrient restriction during pregnancy differentially alters the unfolded protein response in adipose and renal tissue of obese juvenile offspring. FASEB J. 23, 1314-1324 (2009)
C1 [Sharkey, Don; Fainberg, Hernan P.; Sebert, Sylvain; Bos, Petra; Wilson, Vicky; Symonds, Michael E.; Budge, Helen] Univ Nottingham, Inst Clin Res, Ctr Reprod & Early Life, Nottingham NG7 2RD, England.
   [Gardner, David S.] Univ Nottingham, Sch Vet Med & Sci, Loughborough, England.
   [Bell, Rhonda] Univ Alberta, Alberta Inst Human Nutr, Edmonton, AB, Canada.
C3 University of Nottingham; University of Nottingham; University of
   Alberta
RP Symonds, ME (corresponding author), Univ Hosp, Sch Clin Sci, Div Human Dev, E Floor E Block,Derby Rd, Nottingham NG7 2UH, England.
EM michael.symonds@nottingham.ac.uk
RI Fainberg, Hernan/A-2449-2012; Gardner, David S/A-7484-2010
OI Fainberg, Hernan Pablo/0000-0001-9330-9047; Fainberg,
   Hernan/0000-0003-3742-3165; Symonds, Michael/0000-0001-9649-8963;
   Sebert, Sylvain/0000-0001-6681-6983; Bell, Rhonda
   C./0000-0002-4298-9641; Sharkey, Don/0000-0002-4989-8697; Gardner, David
   S/0000-0002-6490-2412
FU British Heart Foundation [FS/05/098/19942, BS/03/01]; European Union
   Sixth Framework for Research and Technical Development of the European
   Community [FOOD-CT-2005-007036]
FX This work was support by a British Heart Foundation clinical fellowship
   (D. S., FS/05/098/19942) and lectureship (D. S. G., BS/03/01) and the
   European Union Sixth Framework for Research and Technical Development of
   the European Community, the Early Nutrition Programming Project
   (FOOD-CT-2005-007036).
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NR 49
TC 38
Z9 42
U1 0
U2 7
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
EI 1530-6860
J9 FASEB J
JI Faseb J.
PD MAY
PY 2009
VL 23
IS 5
BP 1314
EP 1324
DI 10.1096/fj.08-114330
PG 11
WC Biochemistry & Molecular Biology; Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 453ZP
UT WOS:000266651700008
PM 19103646
DA 2025-06-11
ER

PT J
AU Ebenezer, PJ
   Mariappan, N
   Elks, CM
   Haque, M
   Soltani, Z
   Reisin, E
   Francis, J
AF Ebenezer, Philip J.
   Mariappan, Nithya
   Elks, Carrie M.
   Haque, Masudul
   Soltani, Zohreh
   Reisin, Efrain
   Francis, Joseph
TI Effects of pyrrolidine dithiocarbamate on high-fat diet-induced
   metabolic and renal alterations in rats
SO LIFE SCIENCES
LA English
DT Article
DE Metabolic syndrome; Oxidative stress; Kidney; Diet
ID FACTOR-KAPPA-B; MITOCHONDRIAL OXIDATIVE STRESS; OBESE ZUCKER RAT;
   DIABETIC-NEPHROPATHY; INSULIN SENSITIVITY; HEART-FAILURE;
   PARAVENTRICULAR NUCLEUS; PROTEIN; ALPHA; HYPERTENSION
AB Aims: We investigated the effects of the nuclear factor kappa B (NF kappa B) blocker pyrrolidine dithiocarbamate (PDTC) on high-fat diet (HFD)-induced metabolic and renal alterations in obese and lean Zucker rats (OZR and LZR, respectively).
   Main methods: Rats were fed a HFD resembling the typical "Western" diet or a regular diet (RD) and allowed free access to tap water or tap water containing PDTC (150 mg/kg body weight) for 10 weeks: rats were then sacrificed. Total ROS production rates were measured using electron paramagnetic resonance spectroscopy, and superoxide production was measured with lucigenin assay. Blood, plasma, and urine were analyzed. Semi-quantitative reverse transcriptase-polymerase chain reaction and electrophoretic mobility shift assay were conducted to assess NF kappa B mRNA levels and DNA binding activities, respectively: immunofluorescence was performed to assess protein levels.
   Key findings: OZR-HFD rats exhibited significantly higher levels of total renal cortical reactive oxygen species production, plasma lipids, insulin, C-reactive protein, blood urea nitrogen, creatinine, and urinary albumin excretion than all other groups (p < 0.05); these changes were accompanied by a significant decrease in plasma high density lipoprotein levels (p < 0.05). Gene expression levels of desmin, cytokine and oxidative stress genes were significantly higher in the renal cortical tissues of OZR-HFD; NF kappa B p65 DNA binding activity was also significantly higher in these animals. PDTC attenuated these changes.
   Significance: Our data suggest that NF kappa B blockade may prove beneficial in treating the nephropathy often associated with metabolic syndrome. (C) 2009 Elsevier Inc. All rights reserved.
C1 [Ebenezer, Philip J.; Mariappan, Nithya; Elks, Carrie M.; Haque, Masudul; Francis, Joseph] Louisiana State Univ, Sch Vet Med, Dept Comparat Biomed Sci, Baton Rouge, LA 70803 USA.
   [Soltani, Zohreh; Reisin, Efrain] Louisiana State Univ, Hlth Sci Ctr, Sect Nephrol & Hypertens, New Orleans, LA 70112 USA.
C3 Louisiana State University System; Louisiana State University; Louisiana
   State University School of Veterinary Medicine; Louisiana State
   University System; Louisiana State University Health Sciences Center New
   Orleans
RP Francis, J (corresponding author), Louisiana State Univ, Sch Vet Med, Dept Comparat Biomed Sci, Baton Rouge, LA 70803 USA.
EM jfrancis@lsu.edu
RI Francis, Joseph/I-4984-2012; Elks, Carrie/N-1961-2017
OI Francis, Joseph/0000-0002-9502-4579
FU National Heart Lung and Blood Institute [RO1 HL080544-01]
FX These studies were supported by a grant from the National Heart Lung and
   Blood Institute (RO1 HL080544-01) for Dr. Joseph Francis. We sincerely
   thank Dr. Olga Borkhsenious for conducting TEM studies, and Ms. Sherry
   Ring for her assistance with tissue sectioning.
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NR 48
TC 22
Z9 26
U1 0
U2 5
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0024-3205
EI 1879-0631
J9 LIFE SCI
JI Life Sci.
PD AUG 26
PY 2009
VL 85
IS 9-10
BP 357
EP 364
DI 10.1016/j.lfs.2009.06.019
PG 8
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA 491RI
UT WOS:000269596500003
PM 19631668
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Behl, T
   Sehgal, A
   Bala, R
   Chadha, S
AF Behl, Tapan
   Sehgal, Aayush
   Bala, Rajni
   Chadha, Swati
TI Understanding the molecular mechanisms and role of autophagy in obesity
SO MOLECULAR BIOLOGY REPORTS
LA English
DT Review
DE Obesity; Autophagy; Metabolic syndrome; Cardiac autophagy; Insulin
   resistance
ID ADIPOSE-TISSUE AUTOPHAGY; ENDOPLASMIC-RETICULUM STRESS;
   INSULIN-RESISTANCE; BECLIN 1; CARDIAC-HYPERTROPHY; CELL-DEATH; ER
   STRESS; HEALTH; FAT; ACTIVATION
AB Vital for growth, proliferation, subsistence, and thermogenesis, autophagy is the biological cascade, which confers defence against aging and various pathologies. Current research has demonstrated de novo activity of autophagy in stimulation of biological events. There exists a significant association between autophagy activation and obesity, encompassing expansion of adipocytes which facilitates beta cell activity. The main objective of the manuscript is to enumerate intrinsic role of autophagy in obesity and associated complications. The peer review articles published till date were searched using medical databases like PubMed and MEDLINE for research, primarily in English language. Obesity is characterized by adipocytic hypertrophy and hyperplasia, which leads to imbalance of lipid absorption, free fatty acid release, and mitochondrial activity. Detailed evaluation of obesity progression is necessary for its treatment and related comorbidities. Data collected in regard to etiological sustaining of obesity, has revealed hypothesized energy misbalance and neuro-humoral dysfunction, which is stimulated by autophagy. Autophagy regulates chief salvaging events for protein clustering, excessive triglycerides, and impaired mitochondria which is accompanied by oxidative and genotoxic stress in mammals. Autophagy is a homeostatic event, which regulates biological process by eliminating lethal cells and reprocessing physiological constituents, comprising of proteins and fat. Unquestionably, autophagy impairment is involved in metabolic syndromes, like obesity. According to an individual's metabolic outline, autophagy activation is essential for metabolism and activity of the adipose tissue and to retard metabolic syndrome i.e. obesity. The manuscript summarizes the perception of current knowledge on autophagy stimulation and its effect on the obesity.
C1 [Behl, Tapan; Sehgal, Aayush; Bala, Rajni; Chadha, Swati] Chitkara Univ, Chitkara Coll Pharm, Chandigarh, Punjab, India.
C3 Chitkara University, Punjab
RP Behl, T (corresponding author), Chitkara Univ, Chitkara Coll Pharm, Chandigarh, Punjab, India.
EM tapanbehl31@gmail.com
RI Behl, Tapan/W-3523-2019
OI bala, rajni/0000-0002-6960-3403
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NR 114
TC 9
Z9 9
U1 0
U2 10
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0301-4851
EI 1573-4978
J9 MOL BIOL REP
JI Mol. Biol. Rep.
PD MAR
PY 2021
VL 48
IS 3
BP 2881
EP 2895
DI 10.1007/s11033-021-06298-w
EA APR 2021
PG 15
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA RQ2VW
UT WOS:000636166700002
PM 33797660
DA 2025-06-11
ER

PT J
AU Vesterdal, LK
   Danielsen, PH
   Folkmann, JK
   Jespersen, LF
   Aguilar-Pelaez, K
   Roursgaard, M
   Loft, S
   Moller, P
AF Vesterdal, Lise K.
   Danielsen, Pernille H.
   Folkmann, Janne K.
   Jespersen, Line F.
   Aguilar-Pelaez, Karin
   Roursgaard, Martin
   Loft, Steffen
   Moller, Peter
TI Accumulation of lipids and oxidatively damaged DNA in hepatocytes
   exposed to particles
SO TOXICOLOGY AND APPLIED PHARMACOLOGY
LA English
DT Article
DE Comet assay; DNA damage; Inflammation; Nanoparticles; Oxidative stress;
   Steatosis
ID FATTY LIVER-DISEASE; ADHESION MOLECULE EXPRESSION; INSOLUBLE IRIDIUM
   PARTICLES; DIESEL EXHAUST PARTICLES; INSULIN-RESISTANCE; CARBON-BLACK;
   HEPATIC STEATOSIS; AMBIENT AIR; WOOD SMOKE; IN-VITRO
AB Exposure to particles has been suggested to generate hepatosteatosis by oxidative stress mechanisms. We investigated lipid accumulation in cultured human hepatocytes (HepG2) and rat liver after exposure to four different carbon-based particles. HepG2 cells were exposed to particles for 3 h and subsequently incubated for another 18 h to manifest lipid accumulation. In an animal model of metabolic syndrome we investigated the association between intake of carbon black (CB, 14 nm) particles and hepatic lipid accumulation, inflammation and gene expression of Srebp-1, Fasn and Scd-1 involved in lipid synthesis. There was a concentration-dependent increase in intracellular lipid content after exposure to CB in HepG2 cells, which was only observed after co-exposure to oleic/palmitic acid. Similar results were observed in HepG2 cells after exposure to diesel exhaust particles, fullerenes C-60 or pristine single-walled carbon nanotubes. All four types of particles also generated oxidatively damaged DNA, assessed as formamidopyrimidine DNA glycosylase (FPG) sensitive sites, in HepG2 cells after 3 h exposure. The animal model of metabolic syndrome showed increased lipid load in the liver after one oral exposure to 6.4 mg/kg of CB in lean Zucker rats. This was not associated with increased iNOS staining in the liver, indicating that the oral CB exposure was associated with hepatic steatosis rather than steatohepatitis. The lipid accumulation did not seem to be related to increased lipogenesis because there were unaltered gene expression levels in both the HepG2 cells and rat livers. Collectively, exposure to particles is associated with oxidative stress and steatosis in hepatocytes. (C) 2013 Published by Elsevier Inc.
C1 [Vesterdal, Lise K.; Danielsen, Pernille H.; Folkmann, Janne K.; Jespersen, Line F.; Aguilar-Pelaez, Karin; Roursgaard, Martin; Loft, Steffen; Moller, Peter] Univ Copenhagen, Environm Hlth Sect, Dept Publ Hlth, DK-1014 Copenhagen K, Denmark.
C3 University of Copenhagen
RP Moller, P (corresponding author), Univ Copenhagen, Environm Hlth Sect, Dept Publ Hlth, Oster Farimagsgade 5A, DK-1014 Copenhagen K, Denmark.
EM pemo@sund.ku.dk
RI Vesterdal, Lars/D-5227-2011; Roursgaard, Martin/D-7320-2016
OI Roursgaard, Martin/0000-0002-7206-0032; Loft,
   Steffen/0000-0001-9552-8518; Danielsen, Pernille
   Hogh/0000-0001-7212-7818
FU Center for Pharmaceutical Nanomedicine and Nanotoxicology; Lundbeck
   Foundation 'Center for Biomembranes in Nanomedicine'
FX The study was funded by grants from the Center for Pharmaceutical
   Nanomedicine and Nanotoxicology and the Lundbeck Foundation 'Center for
   Biomembranes in Nanomedicine'.
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NR 61
TC 59
Z9 62
U1 1
U2 43
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0041-008X
EI 1096-0333
J9 TOXICOL APPL PHARM
JI Toxicol. Appl. Pharmacol.
PD JAN 15
PY 2014
VL 274
IS 2
BP 350
EP 360
DI 10.1016/j.taap.2013.10.001
PG 11
WC Pharmacology & Pharmacy; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Toxicology
GA 298OE
UT WOS:000330333000018
PM 24121055
DA 2025-06-11
ER

PT J
AU Geetha, R
   Yogalakshmi, B
   Sreeja, S
   Bhavani, K
   Anuradha, CV
AF Geetha, Rajagopalan
   Yogalakshmi, Baskaran
   Sreeja, S.
   Bhavani, K.
   Anuradha, Carani Venkatraman
TI Troxerutin suppresses lipid abnormalities in the heart of
   high-fat-high-fructose diet-fed mice
SO MOLECULAR AND CELLULAR BIOCHEMISTRY
LA English
DT Article
DE High-fat-high-fructose diet; Heart lipids; Oxidative stress; Troxerutin
ID INSULIN SENSITIVITY; METABOLIC SYNDROME; OXIDATIVE STRESS; INDUCED
   HYPERTENSION; ACID; ALPHA; EXPRESSION; LIVER; RATS; TRANSPORTERS
AB The reversal effect of troxerutin (TX) on obesity, insulin resistance, lipid accumulation, oxidative damage, and hypertension induced in the high-fat-high-fructose diet (HFFD)-fed mice model of metabolic syndrome was investigated. Adult male Mus musculus mice of body weight 25-30 g were fed either control diet or HFFD. Each group was divided into two and treated or untreated with TX (150 mg/kg bw, p.o.) from the 16th day. Assays were done in plasma and heart after 30 and 60 days of the experimental period. Significant increase in the levels of glucose and insulin, blood pressure (BP), and oxidative stress were observed after 30 days of HFFD feeding as compared to control. Animals fed HFFD for 60 days developed more severe changes in the above parameters compared to those fed for 30 days. Hearts of HFFD-fed mice registered downregulation of peroxisome proliferator-activated receptor-alpha and peroxisome proliferator-activated receptor gamma coactivator-1 alpha, carnitine palmitoyl transferse-1b and AMP-activated protein kinase; and upregulation of cluster of differentiation 36, fatty acid-binding protein-1, and sterol regulatory element-binding protein-1c after 60 days. TX administration restricted obesity (as seen by Lee's index); improved whole body insulin sensitivity; reduced BP, lipid accumulation, and oxidative damage; upregulated fatty acid (FA) oxidation; and downregulated FA transport and lipogenesis. Histology of heart revealed that TX diminishes inflammatory cell infiltration and fatty degeneration in HFFD-fed mice. The antioxidant property of TX and its ability to influence lipid regulatory genes could be the underlying mechanisms for its beneficial effects.
C1 [Geetha, Rajagopalan; Yogalakshmi, Baskaran; Sreeja, S.; Anuradha, Carani Venkatraman] Annamalai Univ, Dept Biochem & Biotechnol, Annamalainagar 608002, Tamil Nadu, India.
   [Bhavani, K.] Mahatma Gandhi Med Coll & Res Inst, Dept Pathol, Pondicherry, India.
C3 Annamalai University; Mahatma Gandhi Medical College & Research
   Institute
RP Anuradha, CV (corresponding author), Annamalai Univ, Dept Biochem & Biotechnol, Annamalainagar 608002, Tamil Nadu, India.
EM cvaradha@hotmail.com
RI Venkatraman, Anuradha/U-8717-2019; S, SREEJA/KIK-7275-2024
OI Carani Venkatraman, Anuradha/0000-0001-9924-2533; S,
   SREEJA/0000-0002-1667-7492
FU Indian Council of Medical Research, New Delhi, India
FX The first author Mrs. Rajagopalan Geetha is a recipient of Senior
   Research Fellowship from the Indian Council of Medical Research, New
   Delhi, India.
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NR 60
TC 38
Z9 38
U1 0
U2 18
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0300-8177
EI 1573-4919
J9 MOL CELL BIOCHEM
JI Mol. Cell. Biochem.
PD FEB
PY 2014
VL 387
IS 1-2
BP 123
EP 134
DI 10.1007/s11010-013-1877-2
PG 12
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA AA1AN
UT WOS:000330828600013
PM 24173620
DA 2025-06-11
ER

PT J
AU Page, GLJ
   Laight, D
   Cummings, MH
AF Page, G. L. J.
   Laight, D.
   Cummings, M. H.
TI Thiamine deficiency in diabetes mellitus and the impact of thiamine
   replacement on glucose metabolism and vascular disease
SO INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
LA English
DT Review
ID HIGH-DOSE THIAMINE; GLYCATION END-PRODUCTS; ENDOTHELIAL DYSFUNCTION;
   DOUBLE-BLIND; INTESTINAL TRANSPORT; OXIDATIVE STRESS; PHOSPHATE-ESTERS;
   WHOLE-BLOOD; BENFOTIAMINE; CELLS
AB P>Despite the targeting of traditional risk factors for cardiovascular disease, disease burden has not been completely eliminated. Thiamine is an essential cofactor in carbohydrate metabolism and individuals with diabetes are thiamine deficient. The pathophysiology of recognised complications of thiamine deficiency is similar to that underlying atherosclerosis and the metabolic syndrome, namely oxidative stress, inflammation and endothelial dysfunction. This review examines the mechanisms by which thiamine deficiency occurs in individuals with diabetes, how this deficiency leads to hyperglycaemic-induced damage, and the effect of thiamine replacement on vascular disease, endothelial function and oxidative stress. Thiamine administration can prevent the formation of harmful by-products of glucose metabolism, reduce oxidative stress and improve endothelial function. The potential benefit of long-term replacement in those with diabetes is not yet known but may reduce cardiovascular risk and angiopathic complications.
C1 [Page, G. L. J.; Cummings, M. H.] Queen Alexandra Hosp, Acad Dept Diabet & Endocrinol, Portsmouth, Hants, England.
   [Laight, D.] Univ Portsmouth, Sch Pharm & Biomed Sci, Portsmouth, Hants, England.
C3 Portsmouth Hospitals NHS Trust; Queen Alexandra Hospital; University of
   Portsmouth
RP Page, GLJ (corresponding author), Queen Alexandra Hosp, Acad Dept Diabet & Endocrinol, Southwick Hill Rd, Portsmouth, Hants, England.
EM georgina.page@porthosp.nhs.uk
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NR 51
TC 102
Z9 113
U1 0
U2 10
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1368-5031
J9 INT J CLIN PRACT
JI Int. J. Clin. Pract.
PD JUN
PY 2011
VL 65
IS 6
BP 684
EP 690
DI 10.1111/j.1742-1241.2011.02680.x
PG 7
WC Medicine, General & Internal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Pharmacology & Pharmacy
GA 762OF
UT WOS:000290488600013
PM 21564442
OA gold, Green Submitted
DA 2025-06-11
ER

PT J
AU D'Angelo, S
AF D'Angelo, Stefania
TI Diet and Aging: The Role of Polyphenol-Rich Diets in Slow Down the
   Shortening of Telomeres: A Review
SO ANTIOXIDANTS
LA English
DT Review
DE Mediterranean diet; oxidative stress; antioxidant; telomere length;
   polyphenol; aging; nutrition; longevity
ID MEDITERRANEAN DIET; LIFE-STYLE; METABOLIC SYNDROME; OXIDATIVE STRESS;
   TEA CONSUMPTION; FOOD GROUPS; BLACK TEA; LENGTH; BIOAVAILABILITY;
   RESVERATROL
AB The ends of human chromosomes are defended by DNA-protein complexes named telomeres, which inhibit the chromosomes from fusing with each other and from being known as a double-strand break by DNA reparation proteins. Telomere length is a marker of biological aging, and disfunction of telomeres is related to age-related syndromes. Telomere attrition has been shown to be accelerated by oxidative stress and inflammation. Telomere length has been proven to be positively linked with nutritional status in human and animal scientific research as several nutrients influence it through mechanisms that imitate their function in cellular roles including oxidative stress and inflammation. Data reported in this article support the idea that following a low-in-fat and rich-plant polyphenols food diet seems to be able to slow down the shortening of telomeres.
C1 [D'Angelo, Stefania] Parthenope Univ, Dept Med Movement & Wellbeing Sci, I-80133 Naples, Italy.
C3 Parthenope University Naples
RP D'Angelo, S (corresponding author), Parthenope Univ, Dept Med Movement & Wellbeing Sci, I-80133 Naples, Italy.
EM stefania.dangelo@uniparthenope.it
RI D'Angelo, Stefania/AAI-2594-2019
OI D'Angelo, Stefania/0000-0001-7585-5052
FU Miur
FX No Statement Available
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NR 150
TC 16
Z9 16
U1 3
U2 7
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD DEC
PY 2023
VL 12
IS 12
AR 2086
DI 10.3390/antiox12122086
PG 20
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA DH2A0
UT WOS:001131060300001
PM 38136206
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Li, C
   Liu, Q
   Xie, LQ
AF Li, Chen
   Liu, Qing
   Xie, Liqun
TI Suppressing NLRP2 expression accelerates hepatic steatosis: A mechanism
   involving inflammation and oxidative stress
SO BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
LA English
DT Article
DE NAFLD; NLRP2; Inflammation; Oxidative stress; Nrf2
ID NF-KAPPA-B; FATTY LIVER-DISEASE; NAFLD; ACTIVATION; HEPATOCYTES;
   PATHWAY; PROTEIN; NRF2; MICE
AB Nonalcoholic fatty liver disease (NAFLD) is characterized by lipid accumulation and inflammation in the liver, contributing to a broad spectrum of severe pathologies, such as metabolic syndrome and hepatocellular carcinoma. Presently, the pathogenesis that attributes to NAFLD has not been fully understood. NLRP2 has been shown to inhibit the NF-kappa B signaling, and thus may contribute to regulate the inflammatory response. However, its role in NAFLD is largely unclear. In the study, we found that NLRP2 was markedly decreased in liver tissues of individuals with severe steatosis, or in a genetic deficiency (ob/ob) mice. High fat diet (HFD) feeding also led to a significant reduction of NLRP2 in liver of mice. Then, the wild type (WT) and NLRP2 knockout (KO) mice were used to further explore the role of NLRP2 in the NAFLD progression. NLRP2 knockout mice exhibited severer metabolic syndrome and hepatic steatosis after HFD administration, as evidenced by the increased body weight, liver histological changes and lipid accumulation. Moreover, HFD feeding-induced inflammation was significantly accelerated by the loss of NLRP2, as evidenced by the increased expression of pro-inflammatory cytokines and activation of nuclear factor kappa B (NF-kappa B) pathway. In addition, oxidative stress triggered by HFD was further promoted by NLRP2 deletion through repressing NF-E2-related factor 2 (Nrf2) pathway. In vitro, we surprisingly found that promoting Nrf2 activation could attenuate NLRP2 knockout-accelerated inflammation and reactive oxygen species (ROS) generation. Therefore, our study indicated that NLRP2 might be a potential target for developing effective therapeutic strategy to prevent NAFLD progression. (C) 2018 Published by Elsevier Inc.
C1 [Li, Chen] Nanjing Univ Chinese Med, Xuzhou TCM Hosp, Dept Gastroenterol, Xuzhou 221000, Jiangsu, Peoples R China.
   [Liu, Qing] Nanjing Univ Chinese Med, Xuzhou TCM Hosp, Dept Oncol, Xuzhou 221000, Jiangsu, Peoples R China.
   [Xie, Liqun] Nanjing Med Univ, Affiliated Hosp 1, Dept Tradit Chinese Med, Nanjing 210009, Jiangsu, Peoples R China.
C3 Nanjing University of Chinese Medicine; Nanjing University of Chinese
   Medicine; Nanjing Medical University
RP Xie, LQ (corresponding author), Nanjing Med Univ, Affiliated Hosp 1, Dept Tradit Chinese Med, Nanjing 210009, Jiangsu, Peoples R China.
EM liqunxienmu@foxmail.com
FU 4th China National TCM Excellent Talents Training Projects; Jiangsu
   Province TCM Excellent Talents Training Projects 2017 of China; Program
   for youth medical reserve talents of Jiangsu Province of China
   [QNRC2016394]; Project of Administration of Traditional Chinese Medicine
   of Jiang Su Province of China [YB2017088, YB2015085]; Project of Xuzhou
   Science and Technology Bureau of Jiang Su Province of China [KC15SH035];
   Program for Xuzhou youth medical reserve talents of China
FX This work was supported by The 4th China National TCM Excellent Talents
   Training Projects 2017; The Jiangsu Province TCM Excellent Talents
   Training Projects 2017 of China; Program for youth medical reserve
   talents of Jiangsu Province of China (ID: QNRC2016394); Project of
   Administration of Traditional Chinese Medicine of Jiang Su Province of
   China (ID:YB2015085); Project of Administration of Traditional Chinese
   Medicine of Jiang Su Province of China (ID:YB2017088); Project of Xuzhou
   Science and Technology Bureau of Jiang Su Province of China
   (ID:KC15SH035); Program for Xuzhou youth medical reserve talents of
   China.
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NR 37
TC 16
Z9 18
U1 4
U2 25
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0006-291X
EI 1090-2104
J9 BIOCHEM BIOPH RES CO
JI Biochem. Biophys. Res. Commun.
PD DEC 9
PY 2018
VL 507
IS 1-4
BP 22
EP 29
DI 10.1016/j.bbrc.2018.10.132
PG 8
WC Biochemistry & Molecular Biology; Biophysics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics
GA HD8OM
UT WOS:000452816400004
PM 30454891
DA 2025-06-11
ER

PT J
AU Gerber, PA
   Rutter, GA
AF Gerber, Philipp A.
   Rutter, Guy A.
TI The Role of Oxidative Stress and Hypoxia in Pancreatic Beta-Cell
   Dysfunction in Diabetes Mellitus
SO ANTIOXIDANTS & REDOX SIGNALING
LA English
DT Review
DE insulin secretion; hypoxia; zinc; diabetes; beta cell
ID GENOME-WIDE ASSOCIATION; GLYCEROL-PHOSPHATE DEHYDROGENASE; IMPAIRED
   INSULIN-SECRETION; TRANSCRIPTION FACTOR PDX-1; OXYGEN SPECIES
   PRODUCTION; OBSTRUCTIVE SLEEP-APNEA; GLUTATHIONE REDOX STATE;
   FATTY-ACID-METABOLISM; CHELATING-AGENT TPEN; FREE CYTOSOLIC ZN2+
AB Significance: Metabolic syndrome is a frequent precursor of type 2 diabetes mellitus (T2D), a disease that currently affects similar to 8% of the adult population worldwide. Pancreatic beta-cell dysfunction and loss are central to the disease process, although understanding of the underlying molecular mechanisms is still fragmentary.
   Recent Advances: Oversupply of nutrients, including glucose and fatty acids, and the subsequent overstimulation of beta cells, are believed to be an important contributor to insulin secretory failure in T2D. Hypoxia has also recently been implicated in beta-cell damage. Accumulating evidence points to a role for oxidative stress in both processes. Although the production of reactive oxygen species (ROS) results from enhanced mitochondrial respiration during stimulation with glucose and other fuels, the expression of antioxidant defense genes is unusually low (or disallowed) in beta cells.
   Critical Issues: Not all subjects with metabolic syndrome and hyperglycemia go on to develop full-blown diabetes, implying an important role in disease risk for gene-environment interactions. Possession of common risk alleles at the SLC30A8 locus, encoding the beta-cell granule zinc transporter ZnT8, may affect cytosolic Zn2+ concentrations and thus susceptibility to hypoxia and oxidative stress.
   Future Directions: Loss of normal beta-cell function, rather than total mass, is increasingly considered to be the major driver for impaired insulin secretion in diabetes. Better understanding of the role of oxidative changes, its modulation by genes involved in disease risk, and effects on beta-cell identity may facilitate the development of new therapeutic strategies to this disease.
C1 [Gerber, Philipp A.] Univ Zurich Hosp, Dept Endocrinol, Diabet & Clin Nutr, Zurich, Switzerland.
   [Rutter, Guy A.] Imperial Coll London, Dept Med, Sect Cell Biol & Funct Genom, Hammersmith Campus, London W12 0NN, England.
C3 University of Zurich; University Zurich Hospital; Imperial College
   London
RP Rutter, GA (corresponding author), Imperial Coll London, Dept Med, Sect Cell Biol & Funct Genom, Hammersmith Campus, London W12 0NN, England.
EM g.rutter@imperial.ac.uk
RI Gerber, Philipp/C-2145-2015
OI Gerber, Philipp/0000-0002-2476-7076; Rutter, Guy/0000-0001-6360-0343
FU Wellcome Trust (Senior Investigator Award) [WT098424AIA]; MRC Programme
   Grant [MR/J0003042/1]; Biotechnology and Biological Sciences Research
   Council [BB/J015873/1]; Diabetes UK [11/0004210]; Imperial Confidence in
   Concept (ICiC) grant; Royal Society Wolfson Research Merit Award;
   Foundation of Diabetes Research at the University Hospital Zurich;
   Innovative Medicines Initiative Joint Undertaking (IMIDIA) [155005];
   European Union's SeventhFramework Programme (FP7); European Federation
   of Pharmaceutical Industries and Associations (EFPIA) companies; BBSRC
   [BB/J015873/1] Funding Source: UKRI; MRC [MR/K001981/1] Funding Source:
   UKRI
FX GAR is supported by grants from the Wellcome Trust (Senior Investigator
   Award, WT098424AIA), an MRC Programme Grant (MR/J0003042/1),
   Biotechnology and Biological Sciences Research Council (BB/J015873/1)
   and Diabetes UK (11/0004210) project grants, an Imperial Confidence in
   Concept (ICiC) grant, and a Royal Society Wolfson Research Merit Award.
   PG was supported by the Foundation of Diabetes Research at the
   University Hospital Zurich. This work was also supported by the
   Innovative Medicines Initiative Joint Undertaking under grant agreement
   155005 (IMIDIA), resources of which are composed of financial
   contribution from the European Union's SeventhFramework Programme
   (FP7/2007-2013), and European Federation of Pharmaceutical Industries
   and Associations (EFPIA) companies.
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NR 215
TC 457
Z9 501
U1 4
U2 126
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1523-0864
EI 1557-7716
J9 ANTIOXID REDOX SIGN
JI Antioxid. Redox Signal.
PD APR
PY 2017
VL 26
IS 10
BP 501
EP +
DI 10.1089/ars.2016.6755
PG 19
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA EP7PX
UT WOS:000397570800002
PM 27225690
OA Green Published
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Manente, L
   Lucariello, A
   Costanzo, C
   Viglietti, R
   Parrella, G
   Parrella, R
   Gargiulo, M
   De Luca, A
   Chirianni, A
   Esposito, V
AF Manente, Lucrezia
   Lucariello, Angela
   Costanzo, Carmelina
   Viglietti, Rosaria
   Parrella, Giovanni
   Parrella, Roberto
   Gargiulo, Miriam
   De Luca, Antonio
   Chirianni, Antonio
   Esposito, Vincenzo
TI Suppression of Pre Adipocyte Differentiation and Promotion of Adipocyte
   Death by Anti-HIV Drugs
SO IN VIVO
LA English
DT Article
DE HAART; HIV infection; lipodystrophy; adipocyte differentiation;
   metabolic syndrome; oxidative stress; saquinavir; efavirenz; stavudine;
   antiretroviral therapies
ID PROTEASE INHIBITORS; INSULIN-RESISTANCE; HEME OXYGENASE; STEM-CELL;
   LIPODYSTROPHY; ACCUMULATION; EXPRESSION; STRESS
AB In the present study, we investigated the ability of anti-HIV drugs to interfere with normal cell cycle progression and to induce oxidative stress by perturbing the redox environment. Our results provide evidence that anti-HIV drugs have a differential effect on adipocyte cell cycle and differentiation, being able to modify the response to oxidative stress through an increase of reactive oxygen species (ROS) that compromises the induction of phase-2 and antioxidant enzymes. In detail, saquinavir, efavirenz, and stavudine exert antiadipogenic influences on the model 3T3-L1 cell line, perturbing the oxidative response and inducing of apoptosis. When considered together, the effects of anti-HIV drugs on 3T3-L1 pre adipocytes are distinct but commonly antiadipogenic, thus suggesting another additional possible mechanism by which antiretroviral therapies could contribute to lipoatrophy.
C1 [Manente, Lucrezia; Lucariello, Angela; Costanzo, Carmelina; De Luca, Antonio] Univ Naples 2, Dept Med & Publ Hlth, Sect Human Anat, Naples, Italy.
   [Viglietti, Rosaria; Parrella, Giovanni; Parrella, Roberto; Gargiulo, Miriam; Chirianni, Antonio; Esposito, Vincenzo] Third Div Cotugno Hosp, Naples, Italy.
C3 Universita della Campania Vanvitelli
RP Esposito, V (corresponding author), Terza Div Malattie Infett AO Cotugno, Via G Quagliariello 54, I-80131 Naples, Italy.
EM esposvin@libero.it
RI Lucariello, Angela/AAT-6447-2020; De Luca, Antonio/AAD-9562-2020
OI Esposito, Vincenzo/0000-0003-4696-2363
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NR 17
TC 7
Z9 7
U1 0
U2 1
PU INT INST ANTICANCER RESEARCH
PI ATHENS
PA EDITORIAL OFFICE 1ST KM KAPANDRITIOU-KALAMOU RD KAPANDRITI, PO BOX 22,
   ATHENS 19014, GREECE
SN 0258-851X
J9 IN VIVO
JI In Vivo
PD MAR-APR
PY 2012
VL 26
IS 2
BP 287
EP 291
PG 5
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 899ET
UT WOS:000300798800017
PM 22351671
DA 2025-06-11
ER

PT J
AU McClung, CA
AF McClung, Colleen A.
TI How Might Circadian Rhythms Control Mood? Let Me Count the Ways ...
SO BIOLOGICAL PSYCHIATRY
LA English
DT Review
DE Bipolar disorder; circadian rhythms; depression; immune system;
   metabolism; neurogenesis
ID MAJOR DEPRESSION; IMMUNE-SYSTEM; CLOCK GENE; ADULT-RAT; KAPPA-B;
   HIPPOCAMPAL NEUROGENESIS; SUPRACHIASMATIC NUCLEUS; METABOLIC SYNDROME;
   SIGNALING PATHWAY; SOCIAL DEFEAT
AB Mood disorders are serious diseases that affect a large portion of the population. There have been many hypotheses put forth over the years to explain the development of major depression, bipolar disorder, and other mood disorders. These hypotheses include disruptions in monoamine transmission, hypothalamus-pituitary-adrenal axis function, immune function, neurogenesis, mitochondrial dysfunction, and neuropeptide signaling (to name a few). Nearly all people suffering from mood disorders have significant disruptions in circadian rhythms and the sleep/wake cycle. In fact, altered sleep patterns are one of the major diagnostic criteria for these disorders. Moreover, environmental disruptions to circadian rhythms, including shift work, travel across time zones, and irregular social schedules, tend to precipitate or exacerbate mood-related episodes. Recent studies have found that molecular clocks are found throughout the brain and body where they participate in the regulation of most physiological processes, including those thought to be involved in mood regulation. This review will summarize recent data that implicate the circadian system as a vital regulator of a variety of systems that are thought to play a role in the development of mood disorders.
C1 [McClung, Colleen A.] Univ Pittsburgh, Sch Med, Dept Psychiat, Pittsburgh, PA 15219 USA.
   [McClung, Colleen A.] Univ Pittsburgh, Sch Med, Translat Neurosci Program, Pittsburgh, PA 15219 USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE); University
   of Pittsburgh; Pennsylvania Commonwealth System of Higher Education
   (PCSHE); University of Pittsburgh
RP McClung, CA (corresponding author), Univ Pittsburgh, Sch Med, Dept Psychiat, 450 Technol Dr,Suite 223, Pittsburgh, PA 15219 USA.
EM mcclungca@upmc.edu
RI McClung, Colleen/AAA-5943-2019
FU National Institute of Mental Health [MH082876]; National Institute on
   Drug Abuse [DA023988]; McKnight Foundation; National Alliance for
   Research in Schizophrenia and Affective Disorders
FX Work from our group was funded by National Institute of Mental Health
   (MH082876) and National Institute on Drug Abuse (DA023988), as well as
   the McKnight Foundation and National Alliance for Research in
   Schizophrenia and Affective Disorders.
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NR 99
TC 358
Z9 391
U1 1
U2 149
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD AUG 15
PY 2013
VL 74
IS 4
BP 242
EP 249
DI 10.1016/j.biopsych.2013.02.019
PG 8
WC Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Psychiatry
GA 201PY
UT WOS:000323156100004
PM 23558300
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Kohen, I
   Lester, PE
   Lam, S
AF Kohen, Izchak
   Lester, Paula E.
   Lam, Sum
TI Antipsychotic treatments for the elderly: efficacy and safety of
   aripiprazole
SO NEUROPSYCHIATRIC DISEASE AND TREATMENT
LA English
DT Article
DE aripiprazole; antipsychotics; elderly; adverse drug reaction
ID MAJOR DEPRESSIVE DISORDER; LATE-LIFE DEPRESSION; DOUBLE-BLIND;
   ALZHEIMERS-DISEASE; RISK-FACTORS; METABOLIC SYNDROME; INTRAMUSCULAR
   ARIPIPRAZOLE; SCHIZOAFFECTIVE DISORDER; CEREBROVASCULAR EVENTS; BIPOLAR
   DISORDER
AB Delusions, hallucinations and other psychotic symptoms can accompany a number of conditions in late life. As such, elderly patients are commonly prescribed antipsychotic medications for the treatment of psychosis in both acute and chronic conditions. Those conditions include schizophrenia, bipolar disorder, depression and dementia. Elderly patients are at an increased risk of adverse events from antipsychotic medications because of age-related pharmacodynamic and pharmacokinetic changes as well as polypharmacy. Drug selection should be individualized to the patient's previous history of antipsychotic use, current medical conditions, potential drug interactions, and potential side effects of the antipsychotic. Specifically, metabolic side effects should be closely monitored in this population. This paper provides a review of aripiprazole, a newer second generation antipsychotic agent, for its use in a variety of psychiatric disorders in the elderly including schizophrenia, bipolar disorder, dementia, Parkinson's disease and depression. We will review the pharmacokinetics and pharmacodynamics of aripiprazole as well as dosing, diagnostic indications, efficacy studies, and tolerability including its metabolic profile. We will also detail patient focused perspectives including quality of life, patient satisfaction and adherence.
C1 [Kohen, Izchak] N Shore LIJ Hlth Syst, Zucker Hillside Hosp, Div Geriatr Psychiat, Ambulatory Care Pavil, Glen Oaks, NY 11004 USA.
   [Lester, Paula E.] Winthrop Univ Hosp, Div Geriatr Med, Mineola, NY 11501 USA.
   [Lam, Sum] St Johns Univ, Coll Pharm & Allied Hlth Profess, Div Pharm & Geriatr, Queens, NY USA.
C3 Northwell Health; Winthrop University Hospital; Saint John's University
RP Kohen, I (corresponding author), N Shore LIJ Hlth Syst, Zucker Hillside Hosp, Div Geriatr Psychiat, Ambulatory Care Pavil, Room 2106,75-59 263rd St, Glen Oaks, NY 11004 USA.
EM ikohen@nshs.edu
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NR 100
TC 33
Z9 38
U1 0
U2 11
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
EI 1178-2021
J9 NEUROPSYCH DIS TREAT
JI Neuropsychiatr. Dis. Treat.
PY 2010
VL 6
BP 47
EP 58
PG 12
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Psychiatry
GA 821CV
UT WOS:000294953300006
PM 20361061
DA 2025-06-11
ER

PT J
AU Gherghina, ME
   Peride, I
   Tiglis, M
   Neagu, TP
   Niculae, A
   Checherita, IA
AF Gherghina, Mihai-Emil
   Peride, Ileana
   Tiglis, Mirela
   Neagu, Tiberiu Paul
   Niculae, Andrei
   Checherita, Ionel Alexandru
TI Uric Acid and Oxidative Stress-Relationship with Cardiovascular,
   Metabolic, and Renal Impairment
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE uric acid; cardiovascular risk; oxidative stress; chronic kidney
   disease; outcome
ID CHRONIC KIDNEY-DISEASE; C-REACTIVE PROTEIN; SERUM URATE; LOWERING
   THERAPY; ASYMPTOMATIC HYPERURICEMIA; MULTIPLE-SCLEROSIS;
   CELL-PROLIFERATION; GOUT; RISK; PROGRESSION
AB Background: The connection between uric acid (UA) and renal impairment is well known due to the urate capacity to precipitate within the tubules or extra-renal system. Emerging studies allege a new hypothesis concerning UA and renal impairment involving a pro-inflammatory status, endothelial dysfunction, and excessive activation of renin-angiotensin-aldosterone system (RAAS). Additionally, hyperuricemia associated with oxidative stress is incriminated in DNA damage, oxidations, inflammatory cytokine production, and even cell apoptosis. There is also increasing evidence regarding the association of hyperuricemia with chronic kidney disease (CKD), cardiovascular disease, and metabolic syndrome or diabetes mellitus. Conclusions: Important aspects need to be clarified regarding hyperuricemia predisposition to oxidative stress and its effects in order to initiate the proper treatment to determine the optimal maintenance of UA level, improving patients' long-term prognosis and their quality of life.
C1 [Gherghina, Mihai-Emil; Peride, Ileana; Niculae, Andrei; Checherita, Ionel Alexandru] Carol Davila Univ Med & Pharm Bucharest, Dept Nephrol, Bucharest 020021, Romania.
   [Tiglis, Mirela] Carol Davila Univ Med & Pharm Bucharest, Dept Anesthesiol & Intens Care, Bucharest 020021, Romania.
   [Neagu, Tiberiu Paul] Carol Davila Univ Med & Pharm Bucharest, Dept Plast Surg & Reconstruct Microsurg, Bucharest 020021, Romania.
C3 Carol Davila University of Medicine & Pharmacy; Carol Davila University
   of Medicine & Pharmacy; Carol Davila University of Medicine & Pharmacy
RP Peride, I (corresponding author), Carol Davila Univ Med & Pharm Bucharest, Dept Nephrol, Bucharest 020021, Romania.
EM gherghina_mihai92@yahoo.com; ileana_peride@yahoo.com;
   mirelatiglis@gmail.com; dr.neagupaul@gmail.com; niculaeandrei@yahoo.com;
   al.checherita@gmail.com
RI peride, ileana/G-6503-2014; Tiglis, Mirela/AFP-1980-2022; Checherita,
   Ionel/AAX-6544-2021
OI Peride, Ileana/0000-0002-4912-6590; Neagu, Tiberiu
   Paul/0000-0002-4319-1965; Tiglis, Mirela/0000-0003-3542-3217;
   Checherita, Ionel Alexandru/0000-0002-9741-5530
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NR 124
TC 210
Z9 225
U1 36
U2 123
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD MAR
PY 2022
VL 23
IS 6
AR 3188
DI 10.3390/ijms23063188
PG 16
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 0C4GZ
UT WOS:000775275000001
PM 35328614
OA gold, Green Published
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Seo, HA
   Lee, IK
AF Seo, Hyun-Ae
   Lee, In-Kyu
TI The Role of Nrf2: Adipocyte Differentiation, Obesity, and Insulin
   Resistance
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Review
ID ARYL-HYDROCARBON RECEPTOR; DIET-INDUCED OBESITY; OXIDATIVE STRESS;
   METABOLIC SYNDROME; ADIPOSE-TISSUE; ENERGY-METABOLISM; CARNOSIC ACID;
   3T3-L1 CELLS; IN-VITRO; INDUCTION
AB Metabolic diseases, such as type 2 diabetes and obesity, are increasing globally, and much work has been performed to elucidate the regulatory mechanisms of these diseases. Nuclear factor E2-related factor 2 (Nrf2) is a basic leucine zipper transcription factor that serves as a primary cellular defense against the cytotoxic effects of oxidative stress. Recent studies have proposed a close relationship between oxidative stress and energy metabolism-associated disease. The Nrf2 pathway, as a master regulator of cellular defense against oxidative stress, has emerged as a critical target of energy metabolism; however, its effects are controversial. This review examines the current state of research on the role of Nrf2 on energy metabolism, specifically with respect to its participation in adipocyte differentiation, obesity, and insulin resistance, and discusses the possibility of using Nrf2 as a therapeutic target in the clinic.
C1 [Seo, Hyun-Ae] Daegu Fatima Hosp, Dept Internal Med, Taegu 701600, South Korea.
   [Seo, Hyun-Ae; Lee, In-Kyu] Kyungpook Natl Univ, Sch Med, Dept Internal Med, Res Inst Aging & Metab,WCU Program, Taegu 700721, South Korea.
   [Seo, Hyun-Ae; Lee, In-Kyu] Kyungpook Natl Univ, Sch Med, Dept Biochem & Cell Biol, Res Inst Aging & Metab,WCU Program, Taegu 700721, South Korea.
C3 Daegu Fatima Hospital; Kyungpook National University (KNU); Kyungpook
   National University (KNU)
RP Lee, IK (corresponding author), Kyungpook Natl Univ, Sch Med, Dept Internal Med, Res Inst Aging & Metab,WCU Program, 50 Samduk-2Ga, Taegu 700721, South Korea.
EM leei@knu.ac.kr
RI Lee, In-Kyu/AAR-6374-2021
FU National Research Foundation [2012R1A2A1A03670452]; Ministry of
   Education, Science, and Technology; Korea Health Technology RD Project;
   Ministry of Health and Welfare, Republic of Korea [A111345]; Kyungpook
   National University Research Fund
FX This work was supported by Grants from the National Research Foundation
   (2012R1A2A1A03670452 and WCU program R32-10064) funded by the Ministry
   of Education, Science, and Technology and a Grant of the Korea Health
   Technology R&D Project, Ministry of Health and Welfare, Republic of
   Korea (A111345), and supported by Kyungpook National University Research
   Fund, 2012.
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NR 47
TC 75
Z9 85
U1 1
U2 26
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PY 2013
VL 2013
AR 184598
DI 10.1155/2013/184598
PG 7
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA 222TS
UT WOS:000324755100001
PM 24194976
OA Green Published, hybrid, Green Submitted
DA 2025-06-11
ER

PT J
AU Owens, J
AF Owens, Judith
CA Adolescent Sleep Working Grp
   Comm Adolescence
TI Insufficient Sleep in Adolescents and Young Adults: An Update on Causes
   and Consequences
SO PEDIATRICS
LA English
DT Article
DE adolescents; caffeine; car crashes; media use; obesity; sleep loss;
   sleepiness
ID SECONDARY-SCHOOL CHILDREN; BODY-MASS INDEX; INADEQUATE SLEEP;
   COLLEGE-STUDENTS; COMPUTER GAME; PRESCRIPTION STIMULANTS;
   CARDIOMETABOLIC RISK; CAFFEINE CONSUMPTION; JAPANESE ADOLESCENTS;
   DAYTIME SLEEPINESS
AB Chronic sleep loss and associated sleepiness and daytime impairments in adolescence are a serious threat to the academic success, health, and safety of our nation's youth and an important public health issue. Understanding the extent and potential short-and long-term repercussions of sleep restriction, as well as the unhealthy sleep practices and environmental factors that contribute to sleep loss in adolescents, is key in setting public policies to mitigate these effects and in counseling patients and families in the clinical setting. This report reviews the current literature on sleep patterns in adolescents, factors contributing to chronic sleep loss (ie, electronic media use, caffeine consumption), and health-related consequences, such as depression, increased obesity risk, and higher rates of drowsy driving accidents. The report also discusses the potential role of later school start times as a means of reducing adolescent sleepiness.
OI Adelman, William/0009-0007-6425-3196; Marcell, Arik/0000-0001-9873-478X
FU NIGMS NIH HHS [U54 GM104942] Funding Source: Medline
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NR 138
TC 991
Z9 1102
U1 36
U2 627
PU AMER ACAD PEDIATRICS
PI ELK GROVE VILLAGE
PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA
SN 0031-4005
EI 1098-4275
J9 PEDIATRICS
JI Pediatrics
PD SEP
PY 2014
VL 134
IS 3
BP E921
EP E932
DI 10.1542/peds.2014-1696
PG 12
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Pediatrics
GA AO5DN
UT WOS:000341362600038
PM 25157012
OA Green Published
DA 2025-06-11
ER

PT J
AU Pascoe, MC
   Thompson, DR
   Ski, CF
AF Pascoe, Michaela C.
   Thompson, David R.
   Ski, Chantal F.
TI Yoga, mindfulness-based stress reduction and stress-related
   physiological measures: A meta-analysis
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Review
DE Yoga; Mindfulness-based stress reduction; Stress; Inflammation; Exercise
ID RANDOMIZED CONTROLLED-TRIAL; BREAST-CANCER SURVIVORS; LIFE-STYLE
   MODIFICATION; HEART-RATE-VARIABILITY; BLOOD-PRESSURE; MAJOR DEPRESSION;
   HATHA-YOGA; METABOLIC SYNDROME; RESTORATIVE YOGA; DIURNAL CORTISOL
AB Background and objectives: Practices that include yoga asanas and mindfulness-based stress reduction for the management of stress are increasingly popular; however, the neurobiological effects of these practices on stress reactivity are not well understood. Many studies investigating the effects of such practices fail to include an active control group. Given the frequency with which people are selecting such interventions as a form of self management, it is important to determine their effectiveness. Thus, this review investigates the effects of practices that include yoga asanas, with and without mindfulness-based stress reduction, compared to an active control, on physiological markers of stress.
   Materials and methods: A systematic review and meta-analysis of randomised controlled trials published in English compared practices that included yoga asanas, with and without mindfulness-based stress reduction, to an active control, on stress-related physiological measures. The review focused on studies that measured physiological parameters such as blood pressure, heart rate, cortisol and peripheral cytokine expression. MEDLINE, AMED, CINAHL, PsycINFO, SocINDEX, PubMed, and Scopus were searched in May 2016 and updated in December 2016. Randomised controlled trials were included if they assessed at least one of the following outcomes: heart rate, blood pressure, heart rate variability, mean arterial pressure, C-reactive, protein, interleukins or cortisol. Risk of bias assessments included sequence generation, allocation-concealment, blinding of assessors, incomplete outcome data, selective outcome reporting and other sources of bias. Meta-analysis was undertaken using Comprehensive Meta-Analysis Software Version 3. Sensitivity analyses were performed using 'one-study removed' analysis. Subgroup analysis was conducted for different yoga and control group types, including mindfulness-based stress reduction versus non-mindfulness-based stress reduction based interventions, different populations, length of intervention, and method of data analysis. A random-effects model was used in all analyses.
   Results: Forty two studies were included in the meta-analysis. Interventions that included yoga asanas were associated with reduced evening cortisol, waking cortisol, ambulatory systolic blood pressure, resting heart rate, high frequency heart rate variability, fasting blood glucose, cholesterol and low density lipoprotein, compared to active control. However, the reported interventions were heterogeneous.
   Conclusions: Practices that include yoga asanas appear to be associated with improved regulation of the sympathetic nervous system and hypothalamic-pituitary-adrenal system in various populations.
C1 [Pascoe, Michaela C.] Peter MacCallum Canc Ctr, Dept Canc Experiences, 305 Grattan St, Melbourne, Vic 3000, Australia.
   [Thompson, David R.; Ski, Chantal F.] Univ Melbourne, Dept Psychiat, Melbourne, Vic 3010, Australia.
   [Thompson, David R.] Monash Univ, Dept Epidemiol & Prevent Med, Melbourne, Vic 3000, Australia.
C3 Peter Maccallum Cancer Center; University of Melbourne; Monash
   University
RP Pascoe, MC (corresponding author), Peter MacCallum Canc Ctr, Dept Canc Experiences, 305 Grattan St, Melbourne, Vic 3000, Australia.
EM Michaela.Pascoe@petermac.org; David.Thompson@unimelb.edu.au;
   Chantal.Ski@unimelb.edu.au
RI Ski, Chantal/HNS-2574-2023; Thompson, David/E-2431-2018
OI Pascoe, Michaela/0000-0002-3831-5660; Ski, Chantal/0000-0003-1324-2933;
   Thompson, David/0000-0001-8518-6307
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NR 103
TC 259
Z9 291
U1 10
U2 180
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
EI 1873-3360
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD DEC
PY 2017
VL 86
BP 152
EP 168
DI 10.1016/j.psyneuen.2017.08.008
PG 17
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA FN1WG
UT WOS:000415781300019
PM 28963884
DA 2025-06-11
ER

PT J
AU Zaman, CF
   Sultana, J
   Dey, P
   Dutta, J
   Mustarin, S
   Tamanna, N
   Roy, A
   Bhowmick, N
   Khanam, M
   Sultana, S
   Chowdhury, S
   Khanam, F
   Sakibuzzaman, M
   Dutta, P
AF Zaman, Chowdhury F.
   Sultana, Jakia
   Dey, Proma
   Dutta, Jui
   Mustarin, Sadia
   Tamanna, Nuzhat
   Roy, Aditi
   Bhowmick, Nisha
   Khanam, Mousumi
   Sultana, Sadia
   Chowdhury, Selia
   Khanam, Farjana
   Sakibuzzaman, Md
   Dutta, Priyata
TI A Multidisciplinary Approach and Current Perspective of Nonalcoholic
   Fatty Liver Disease: A Systematic Review
SO CUREUS JOURNAL OF MEDICAL SCIENCE
LA English
DT Review
DE nafld; nonalcoholic fatty liver disease; covid-19; gut microbiota;
   hepatocellular carcinoma (hcc); metabolic syndrome; obesity;
   nonalcoholic fatty liver disease (nafld)
ID HEPATOCELLULAR-CARCINOMA; MEDITERRANEAN DIET; PATHOGENESIS; PREVENTION;
   MANAGEMENT; FUTURE
AB In recent times, nonalcoholic fatty liver disease (NAFLD) has been considered one of the major causes of liver disease across the world. NAFLD is defined as the deposition of triglycerides in the liver and is associated with obesity and metabolic syndrome. Hyperinsulinemia, insulin resistance (IR), fatty liver, hepatocyte injury, unbalanced proinflammatory cytokines, mitochondrial dysfunction, oxidative stress, liver inflammation, and fibrosis are the main pathogenesis in NAFLD. Recent studies suggest that the action of intestinal microbiota through chronic inflammation, increased intestinal permeability, and energy uptake plays a vital role in NAFLD. Moreover, polycystic ovarian syndrome also causes NAFLD development through IR. Age, gender, race, ethnicity, sleep, diet, sedentary lifestyle, and genetic and epigenetic pathways are some contributing factors of NAFLD that can exacerbate the risk of liver cirrhosis and hepatocellular carcinoma (HCC) and eventually lead to death. NAFLD has various presentations, including fatigue, unexplained weight loss, bloating, upper abdominal pain, decreased appetite, headache, anxiety, poor sleep, increased thirst, palpitation, and a feeling of warmth. Some studies have shown that NAFLD with severe coronavirus disease 2019 (COVID-19) has poor outcomes. The gold standard for NAFLD diagnosis is liver biopsy. Other diagnostic tools are imaging tests, serum biomarkers, microbiota markers, and tests for extrahepatic complications. There are no specific treatments for NAFLD. Therefore, the main concern for NAFLD is treating the comorbid conditions such as anti-diabetic agents for type 2 diabetes mellitus, statins to reduce HCC progression, antioxidants to prevent hepatocellular damage, and bariatric surgery for patients with a BMI of >40 kg/m(2) and >35 kg/m(2) with comorbidities. Lifestyle and dietary changes are considered preventive strategies against NAFLD advancement. Inadequate treatment of NAFLD further leads to cardiac consequences, sleep apnea, chronic kidney disease, and inflammatory bowel disease. In this systematic review, we have briefly discussed the risk factors, pathogenesis, clinical features, and numerous consequences of NAFLD. We have also reviewed various guidelines for NAFLD diagnosis along with existing therapeutic strategies for the management and prevention of the disease.
C1 [Zaman, Chowdhury F.] Jahurul Islam Med Coll & Hosp, Med & Surg, Kishoreganj, Bangladesh.
   [Sultana, Jakia; Dutta, Jui] Cumilla Med Coll, Med, Cumilla, Bangladesh.
   [Dey, Proma] Chittagong Med Coll, Internal Med, Chattogram, Bangladesh.
   [Mustarin, Sadia] Mymensingh Med Coll, Med, Mymensingh, Bangladesh.
   [Tamanna, Nuzhat] Rangpur Med Coll & Hosp, Med, Rangpur, Bangladesh.
   [Roy, Aditi] Sher E Bangla Med Coll, Med, Barisal, Bangladesh.
   [Bhowmick, Nisha] Shaheed Ziaur Rahman Med Coll, Med, Bogra, Bangladesh.
   [Khanam, Mousumi; Chowdhury, Selia] Dhaka Med Coll, Internal Med, Dhaka, Bangladesh.
   [Sultana, Sadia] Anwer Khan Modern Med Coll, Med, Dhaka, Bangladesh.
   [Khanam, Farjana] Cent Med Coll, Med, Cumilla, Bangladesh.
   [Sakibuzzaman, Md] Univ Toledo, Neurol, 2801 W Bancroft St, Toledo, OH 43606 USA.
   [Sakibuzzaman, Md] Univ Mississippi, Med Ctr, Internal Med, Jackson, MS 39216 USA.
   [Sakibuzzaman, Md] Sir Salimullah Med Coll, Internal Med, Dhaka, Bangladesh.
   [Sakibuzzaman, Md] Mayo Clin, Expt Pathol Canc Biol, Rochester, MN USA.
   [Dutta, Priyata] St Joseph Mercy Ann Arbor, Internal Med, Trinity Hlth, Ann Arbor, MI USA.
C3 Chittagong Medical College; Mymensingh Medical College; Rangpur Medical
   College; Sher-E-Bangla Medical College (SBMC); Dhaka Medical College;
   University System of Ohio; University of Toledo; University of
   Mississippi Medical Center; University of Mississippi; Sir Salimullah
   Medical College; Mayo Clinic; Saint Joseph Mercy Health System (SJMHS)
RP Dey, P (corresponding author), Chittagong Med Coll, Internal Med, Chattogram, Bangladesh.
EM proma.dey.cmc@gmail.com
RI Dutta, Priyata/KSM-6252-2024
OI Dutta, Priyata/0000-0001-7954-9511
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NR 45
TC 10
Z9 10
U1 1
U2 27
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
EI 2168-8184
J9 CUREUS J MED SCIENCE
JI Cureus J Med Sci
PD SEP 27
PY 2022
VL 14
IS 9
AR e29657
DI 10.7759/cureus.29657
PG 12
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA 5M5CF
UT WOS:000871112300003
PM 36320966
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Cernackova, A
   Durackova, Z
   Trebaticka, J
   Mravec, B
AF Cernackova, Alena
   Durackova, Zdenka
   Trebaticka, Jana
   Mravec, Boris
TI Neuroinflammation and depressive disorder: The role of the hypothalamus
SO JOURNAL OF CLINICAL NEUROSCIENCE
LA English
DT Review
DE Inflammation; Hypothalamus; HPA axis; Stress; Depressive disorder
ID SOCIAL DEFEAT PROMOTES; CHRONIC STRESS; MESSENGER-RNA; IMMUNE-SYSTEM;
   HPA AXIS; KAPPA-B; INFLAMMATION; INTERLEUKIN-1-BETA; ACTIVATION;
   MICROGLIA
AB Data accumulated over the last two decades has demonstrated that hypothalamic inflammation plays an important role in the etiopathogenesis of the most prevalent diseases, such as cardiovascular diseases, metabolic syndrome, and even cancer. Recent findings indicate that hypothalamic inflammation is also associated with stress exposure and certain psychiatric diseases, such as depressive disorder. Mechanistic studies have shown that intense and/or chronic stress exposure is accompanied by the synthesis of inflammatory molecules in the hypothalamus, altered hypothalamic-pituitary-adrenal axis activity, and development of glucocorticoid resistance. Consequently, these factors might play a role in the etiopathogenesis of psychiatric disorders. We propose that hypothalamic inflammation represents an interconnection between somatic diseases and depressive disorder. These assumptions are discussed in this mini-review in the light of available data from studies focusing on hypothalamic inflammation. (C) 2020 Elsevier Ltd. All rights reserved.
C1 [Cernackova, Alena; Mravec, Boris] Comenius Univ, Fac Med, Inst Physiol, Bratislava, Slovakia.
   [Cernackova, Alena; Mravec, Boris] Slovak Acad Sci, Inst Expt Endocrinol, Biomed Res Ctr, Bratislava, Slovakia.
   [Durackova, Zdenka] Comenius Univ, Fac Med, Inst Med Chem Biochem & Clin Biochem, Bratislava, Slovakia.
   [Trebaticka, Jana] Comenius Univ, Fac Med, Dept Child & Adolescent Psychiat, Bratislava, Slovakia.
   [Trebaticka, Jana] Child Univ Hosp, Bratislava, Slovakia.
C3 Comenius University Bratislava; Slovak Academy of Sciences; Slovak
   Academy of Sciences; Biomedical Research Center, SAS; Institute of
   Experimental Endocrinology, SAS; Comenius University Bratislava;
   Comenius University Bratislava
RP Cernackova, A (corresponding author), Fac Med, Inst Physiol, Sasinkova 2, Bratislava 81372, Slovakia.
EM cernackova1@uniba.sk
RI Ďuračková, Zdenka/ABD-1310-2021; Cernackova, Alena/HLX-2024-2023
OI Mravec, Boris/0000-0002-3177-6819
FU Slovak Research and Development Agency [APVV-17-0090, APVV 15-0063];
   Interreg, Slovakia-Austria; European Regional Development Fund [V-A
   SK-AT V014 -NutriAging]
FX This work was supported by the Slovak Research and Development Agency
   (APVV-17-0090, APVV 15-0063) Interreg, Slovakia-Austria, European
   Regional Development Fund: V-A SK-AT V014 -NutriAging.
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NR 64
TC 47
Z9 49
U1 0
U2 16
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0967-5868
EI 1532-2653
J9 J CLIN NEUROSCI
JI J. Clin. Neurosci.
PD MAY
PY 2020
VL 75
BP 5
EP 10
DI 10.1016/j.jocn.2020.03.005
PG 6
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology
GA LG7IU
UT WOS:000528270700002
PM 32217047
DA 2025-06-11
ER

PT J
AU Shao, D
   Oka, SI
   Liu, T
   Zhai, P
   Ago, T
   Sciarretta, S
   Li, H
   Sadoshima, J
AF Shao, Dan
   Oka, Shin-ichi
   Liu, Tong
   Zhai, Peiyong
   Ago, Tetsuro
   Sciarretta, Sebastiano
   Li, Hong
   Sadoshima, Junichi
TI A Redox-Dependent Mechanism for Regulation of AMPK Activation by
   Thioredoxin1 during Energy Starvation
SO CELL METABOLISM
LA English
DT Article
ID PROTEIN-KINASE; OXIDATIVE STRESS; MYOCARDIAL-ISCHEMIA;
   CARDIAC-HYPERTROPHY; METABOLIC SYNDROME; APOPTOSIS; AUTOPHAGY; PREVENTS;
   PATHWAY; DISEASE
AB 5'-AMP-activated protein kinase (AMPK) is a key regulator of metabolism and survival during energy stress. Dysregulation of AMPK is strongly associated with oxidative-stress-related disease. However, whether and how AMPK is regulated by intracellular redox status remains unknown. Here we show that the activity of AMPK is negatively regulated by oxidation of Cys130 and Cys174 in its a subunit, which interferes with the interaction between AMPK and AMPK kinases (AMPKK). Reduction of Cys130/Cys174 is essential for activation of AMPK during energy starvation. Thioredoxin1 (Trx1), an important reducing enzyme that cleaves disulfides in proteins, prevents AMPK oxidation, serving as an essential cofactor for AMPK activation. High-fat diet consumption downregulates Trx1 and induces AMPK oxidation, which enhances cardiomyocyte death during myocardial ischemia. Thus, Trx1 modulates activation of the cardioprotective AMPK pathway during ischemia, functionally linking oxidative stress and metabolism in the heart.
C1 [Shao, Dan; Oka, Shin-ichi; Zhai, Peiyong; Ago, Tetsuro; Sciarretta, Sebastiano; Sadoshima, Junichi] Rutgers Biomed & Hlth Sci, Dept Cell Biol & Mol Med, Cardiovasc Res Inst, New Jersey Med Sch, Newark, NJ 07103 USA.
   [Liu, Tong; Li, Hong] Rutgers Biomed & Hlth Sci, Ctr Adv Prote Res, Newark, NJ 07103 USA.
   [Liu, Tong; Li, Hong] Rutgers Biomed & Hlth Sci, Dept Biochem & Mol Biol, Ctr Canc, New Jersey Med Sch, Newark, NJ 07103 USA.
C3 Rutgers University System; Rutgers University New Brunswick; Rutgers
   University Biomedical & Health Sciences; Rutgers University System;
   Rutgers University New Brunswick; Rutgers University Biomedical & Health
   Sciences; Rutgers University System; Rutgers University New Brunswick;
   Rutgers University Biomedical & Health Sciences
RP Sadoshima, J (corresponding author), Rutgers Biomed & Hlth Sci, Dept Cell Biol & Mol Med, Cardiovasc Res Inst, New Jersey Med Sch, Newark, NJ 07103 USA.
EM sadoshju@njms.rutgers.edu
RI Li, Hong/K-8436-2013; Sciarretta, Sebastiano/K-5161-2016
OI Li, Hong/0000-0001-5731-5335; Sadoshima, Junichi/0000-0003-3724-4132;
   Ago, Tetsuro/0000-0003-4560-6594; Sciarretta,
   Sebastiano/0000-0002-8633-6896
FU U.S. Public Health Service [HL67724, HL91469, HL102738, HL112330,
   AG23039]; Foundation of Leducq Transatlantic Network of Excellence; NIH
   [NS046593]
FX We thank Daniela Zablocki and Christopher D. Brady for critical reading
   of the manuscript. This work was supported in part by U.S. Public Health
   Service Grants HL67724, HL91469, HL102738, HL112330, and AG23039 (J.S.)
   and the Foundation of Leducq Transatlantic Network of Excellence (J.S.).
   The Orbitrap mass spectrometer used in this study is supported in part
   by NIH grant NS046593 (H. L.) for the support of a New Jersey Medical
   School Cancer Center Neuroproteomics Core Facility, Rutgers Biomedical
   and Health Sciences.
CR Abdulla J, 2008, EUR HEART J, V29, P594, DOI 10.1093/eurheartj/ehn010
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NR 31
TC 185
Z9 215
U1 2
U2 31
PU CELL PRESS
PI CAMBRIDGE
PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA
SN 1550-4131
EI 1932-7420
J9 CELL METAB
JI Cell Metab.
PD FEB 4
PY 2014
VL 19
IS 2
BP 232
EP 245
DI 10.1016/j.cmet.2013.12.013
PG 14
WC Cell Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Endocrinology & Metabolism
GA 304CE
UT WOS:000330722600009
PM 24506865
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Rajakumar, S
   Nachiappan, V
AF Rajakumar, Selvaraj
   Nachiappan, Vasanthi
TI Lipid droplets alleviate cadmium induced cytotoxicity in
   Saccharomyces cerevisiae
SO TOXICOLOGY RESEARCH
LA English
DT Article
ID INDUCED APOPTOSIS; OXIDATIVE STRESS; NEUTRAL LIPIDS; YEAST;
   TRIACYLGLYCEROL; ACYLTRANSFERASE; TOXICITY; CELLS;
   PHOSPHATIDYLETHANOLAMINE; SCHIZOSACCHAROMYCES
AB Cadmium (Cd) induces oxidative stress that generates reactive oxygen species (ROS) and increased lipid accumulation. However, very little is known about the role of oxidative stress in triacylglycerol (TAG) accumulation. TAG accumulation is deleterious to health and may result in obesity-associated metabolic syndrome. Hence TAG accumulation plays an important role in Cd induced cytotoxicity. The exposure of Wild-type (WT) cells to Cd, resulted in TAG accumulation and also enhanced viability when compared to TAG mutants (dga1 Delta, lro1 Delta and are2 Delta). The inhibition of lipolysis also increased the tolerance of the cells to Cd. Fluorescence microscopy observations using acridine orange and DHR123 staining demonstrated that the TAG deficient mutants showed enhanced cell death and ROS production. The over expression of DGA1 and LRO1 rescued the Cd induced cytotoxicity by enhancing the formation of LDs. Results of this study revealed the possible metabolic link between LDs and oxidative stress in S. cerevisiae.
C1 [Rajakumar, Selvaraj; Nachiappan, Vasanthi] Bharathidasan Univ, Biomembrane Lab, Dept Biochem, Ctr Excellence Life Sci, Tiruchirappalli 620024, Tamil Nadu, India.
C3 Bharathidasan University
RP Nachiappan, V (corresponding author), Bharathidasan Univ, Biomembrane Lab, Dept Biochem, Ctr Excellence Life Sci, Tiruchirappalli 620024, Tamil Nadu, India.
EM vasanthibch@gmail.com
RI Selvaraj, Rajakumar/AAO-6358-2020
OI Nachiappan, Vasanthi/0000-0001-9891-3657
FU Rajiv Gandhi National Fellowship Scheme from UGC, India
FX Infrastructure facility by DST-FIST, Biochemistry Department and
   confocal microscopy facility by DST-PURSE at Bharathidasan University is
   gratefully acknowledged. SR is supported by a fellowship from the Rajiv
   Gandhi National Fellowship Scheme from UGC, India. We thank Prof. Ram
   Rajasekharan, CSIR-CFTRI, Mysore, India, Prof. Daum Gunther, Dr K.
   Athenstaedt, University of Graz, Austria, and Prof. Sten. Stymne,
   Germany, for providing mutant strains for this work. We also acknowledge
   Central Instruments Facility and Services (CIFS), CFTRI, Mysore, India
   for helping us to conduct the GC-MS study.
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NR 45
TC 9
Z9 10
U1 2
U2 13
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 2045-452X
EI 2045-4538
J9 TOXICOL RES-UK
JI Toxicol. Res.
PD JAN 1
PY 2017
VL 6
IS 1
BP 30
EP 41
DI 10.1039/c6tx00187d
PG 12
WC Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Toxicology
GA EI9GZ
UT WOS:000392817200003
PM 30090475
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Sutin, AR
   Terracciano, A
   Deiana, B
   Uda, M
   Schlessinger, D
   Lakatta, EG
   Costa, PT
AF Sutin, Angelina R.
   Terracciano, Antonio
   Deiana, Barbara
   Uda, Manuela
   Schlessinger, David
   Lakatta, Edward G.
   Costa, Paul T., Jr.
TI Cholesterol, triglycerides, and the Five-Factor Model of personality
SO BIOLOGICAL PSYCHOLOGY
LA English
DT Article
DE Personality; Depression; Impulsivity; Cholesterol; Triglycerides
ID CORONARY-HEART-DISEASE; NEO-PI-R; MIDDLE-AGED MEN; DEPRESSIVE SYMPTOMS;
   METABOLIC SYNDROME; YOUNG-ADULTS; A-BEHAVIOR; SERUM-CHOLESTEROL;
   HOSTILITY; TRAITS
AB Unhealthy lipid levels are among the leading controllable risk factors for coronary heart disease. To identify the psychological factors associated with dyslipidemia, this study investigates the personality correlates of cholesterol (total, LDL, and HDL) and triglycerides. A community-based sample (N = 5532) from Sardinia, Italy, had their cholesterol and triglyceride levels assessed and completed a comprehensive personality questionnaire, the NEO-PI-R. All analyses controlled for age, sex, BMI, smoking, drinking, hypertension, and diabetes. Low Conscientiousness and traits related to impulsivity were associated with lower HDL cholesterol and higher triglycerides. Compared to the lowest 10%, those who scored in top 10% on Impulsivity had a 2.5 times greater risk of exceeding the clinical threshold for elevated triglycerides (OR = 2.51, CI = 1.56-4.07). In addition, sex moderated the association between trait depression (a component of Neuroticism) and HDL cholesterol, such that trait depression was associated with lower levels of HDL cholesterol in women but not men. When considering the connection between personality and health, unhealthy lipid profiles may be one intermediate biomarker between personality and morbidity and mortality. Published by Elsevier B.V.
C1 [Sutin, Angelina R.] NIA, Lab Personal & Cognit, NIH, DHHS, Baltimore, MD 21224 USA.
C3 National Institutes of Health (NIH) - USA; NIH National Institute on
   Aging (NIA)
RP Sutin, AR (corresponding author), NIA, Lab Personal & Cognit, NIH, DHHS, 251 Bayview Blvd, Baltimore, MD 21224 USA.
EM sutina@mail.nih.gov
RI Lakatta, Edward/AAL-1447-2020; Uda, Manuela/AAC-2645-2019; Costa,
   Paul/AAH-6594-2019; Terracciano, Antonio/H-7403-2019
OI Terracciano, Antonio/0000-0001-5799-8885; Costa,
   Paul/0000-0003-4375-1712; UDA, MANUELA/0000-0002-4890-6456; Lakatta,
   Edward/0000-0002-4772-0035
FU NIH; National Institute on Aging
FX This research was supported in part by the Intramural Research Program
   of the NIH, National Institute on Aging. Paul Costa receives royalties
   from the Revised NEO Personality Inventory.
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NR 60
TC 79
Z9 83
U1 2
U2 25
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0301-0511
EI 1873-6246
J9 BIOL PSYCHOL
JI Biol. Psychol.
PD MAY
PY 2010
VL 84
IS 2
BP 186
EP 191
DI 10.1016/j.biopsycho.2010.01.012
PG 6
WC Psychology, Biological; Behavioral Sciences; Psychology; Psychology,
   Experimental
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Behavioral Sciences
GA 616GQ
UT WOS:000279197500004
PM 20109519
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Vrany, EA
   Berntson, JM
   Khambaty, T
   Stewart, JC
AF Vrany, Elizabeth A.
   Berntson, Jessica M.
   Khambaty, Tasneem
   Stewart, Jesse C.
TI Depressive Symptoms Clusters and Insulin Resistance: Race/Ethnicity as a
   Moderator in 2005-2010 NHANES Data
SO ANNALS OF BEHAVIORAL MEDICINE
LA English
DT Article
DE Depression; Depressive symptom clusters; Insulin resistance; Diabetes;
   Race/ethnicity; NHANES
ID HOMEOSTASIS MODEL ASSESSMENT; PATIENT HEALTH QUESTIONNAIRE; TYPE-2
   DIABETES-MELLITUS; ARTERY RISK DEVELOPMENT; C-REACTIVE PROTEIN;
   METABOLIC SYNDROME; DIFFERENTIAL ASSOCIATION; COGNITIVE SYMPTOMS;
   RESIDUAL SYMPTOMS; MAJOR DEPRESSION
AB Background Although depression has been linked to insulin resistance, few studies have examined depressive symptom clusters.
   Purpose We examined whether certain depressive symptom clusters are more strongly associated with insulin resistance in a nationally representative sample, and we evaluated potential moderators and mediators.
   Methods Respondents were 4487 adults from NHANES 2005-2010. Depressive symptoms were measured with the Patient Health Questionnaire-9 (PHQ-9), and insulin resistance was indexed by the homeostatic model assessment (HOMA) score.
   Results Positive relationships between PHQ-9 total, somatic, and cognitive-affective scores and HOMA score were detected (ps <0.001). In a simultaneous model, the somatic (p= 0.017), but not the cognitive-affective (p= 0.071), score remained associated with HOMA score. We observed evidence of (a) moderation by race/ethnicity (relationships stronger in non-Hispanic Whites) and (b) mediation by body mass and inflammation.
   Conclusions The depressive symptoms-insulin resistance link may be strongest among non-Hispanic Whites and may be driven slightly more by the somatic symptoms.
C1 [Vrany, Elizabeth A.; Berntson, Jessica M.; Khambaty, Tasneem; Stewart, Jesse C.] Indiana Univ Purdue Univ, Dept Psychol, 402 North Blackford St,LD 100E, Indianapolis, IN 46202 USA.
C3 Purdue University System; Purdue University; Purdue University in
   Indianapolis
RP Stewart, JC (corresponding author), Indiana Univ Purdue Univ, Dept Psychol, 402 North Blackford St,LD 100E, Indianapolis, IN 46202 USA.
EM jstew@iupui.edu
RI Khambaty, Tasneem/JED-6735-2023
OI Vrany, Elizabeth/0000-0003-1452-705X
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NR 69
TC 21
Z9 24
U1 1
U2 10
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0883-6612
EI 1532-4796
J9 ANN BEHAV MED
JI Ann. Behav. Med.
PD FEB
PY 2016
VL 50
IS 1
BP 1
EP 11
DI 10.1007/s12160-015-9725-0
PG 11
WC Psychology, Multidisciplinary
WE Social Science Citation Index (SSCI)
SC Psychology
GA DI6VU
UT WOS:000373639100001
PM 26318593
OA Bronze
DA 2025-06-11
ER

PT J
AU Salimi, Z
   Rostami, M
   Milasi, YE
   Mafi, A
   Raoufinia, R
   Kiani, A
   Sakhaei, F
   Ghezelbash, B
   Butler, AE
   Mohammad-Sadeghipour, M
   Sahebkar, A
AF Salimi, Zohreh
   Rostami, Mehdi
   Milasi, Yaser Eshaghi
   Mafi, Alireza
   Raoufinia, Ramin
   Kiani, Amirhossein
   Sakhaei, Fariba
   Ghezelbash, Behrooz
   Butler, Alexandra E.
   Mohammad-Sadeghipour, Maryam
   Sahebkar, Amirhossein
TI Unfolded Protein Response Signaling in Hepatic Stem Cell Activation in
   Liver Fibrosis
SO CURRENT PROTEIN & PEPTIDE SCIENCE
LA English
DT Review
DE Stresses; endoplasmic reticulum; hepatic satellite cells; unfolded
   protein response; liver fibrosis; drug therapy
ID ENDOPLASMIC-RETICULUM STRESS; ER-STRESS; OXIDATIVE STRESS; STELLATE
   CELLS; MESSENGER-RNA; MITOCHONDRIAL DYNAMICS; BAX INHIBITOR-1;
   AUTOPHAGY; APOPTOSIS; DEATH
AB Frequent exposure to various external and internal adverse forces (stresses) disrupts ell protein homeostasis through endoplasmic reticulum (ER) capacity saturation. his process leads to the unfolded protein response (UPR), which aims to re-establish/maintain ptimal cellular equilibrium. This complex mechanism is involved in the pathogenesis of various disorders, such as metabolic syndrome, ibrotic diseases, neurodegeneration, and cancer, by altering cellular metabolic changes integral to ctivating the hepatic stellate cells (HSCs). The development of hepatic fibrosis is one of he consequences of UPR activation. Therefore, novel therapies that target the UPR pathway effectively and pecifically are being studied. This article covers the involvement of the UPR signaling pathway in cellular damage in liver fibrosis. Investigating the pathogenic pathways related to the ER/UPR stress axis that contribute to liver fibrosis can help to guide future drug therapy approaches.
C1 [Salimi, Zohreh; Milasi, Yaser Eshaghi; Mafi, Alireza; Sakhaei, Fariba] Isfahan Univ Med Sci, Dept Clin Biochem, Sch Pharm & Pharmaceut Sci, Esfahan, Iran.
   [Rostami, Mehdi] Mashhad Univ Med Sci, Fac Med, Dept Clin Biochem, Mashhad, Iran.
   [Mafi, Alireza] Isfahan Univ Med Sci, Nutr & Food Secur Res Ctr, Esfahan, Iran.
   [Raoufinia, Ramin] Mashhad Univ Med Sci, Sch Med, Med Genet & Mol Med Dept, Mashhad, Iran.
   [Raoufinia, Ramin] Neyshabur Univ Med Sci, Neyshabur, Iran.
   [Kiani, Amirhossein] Ahvaz Jundishapur Univ Med Sci, Fac Med, Dept Immunol, Ahvaz, Iran.
   [Ghezelbash, Behrooz] Isfahan Univ Med Sci, Dept Immunol, Sch Med, Esfahan, Iran.
   [Butler, Alexandra E.] Royal Coll Surg Ireland, Res Dept, POB 15503, Busaiteen, Adliya, Bahrain.
   [Mohammad-Sadeghipour, Maryam] Kerman Univ Med Sci, Afzalipoor Fac Med, Dept Clin Biochem, Kerman, Iran.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Biotechnol Res Ctr, Mashhad, Iran.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Appl Biomed Res Ctr, Mashhad, Iran.
C3 Isfahan University of Medical Sciences; Mashhad University of Medical
   Sciences; Isfahan University of Medical Sciences; Mashhad University of
   Medical Sciences; Ahvaz Jundishapur University of Medical Sciences
   (AJUMS); Isfahan University of Medical Sciences; Royal College of
   Surgeons - Ireland; Royal College of Surgeons in Ireland - Medical
   University of Bahrain; Kerman University of Medical Sciences; Mashhad
   University of Medical Sciences; Mashhad University of Medical Sciences
RP Mohammad-Sadeghipour, M (corresponding author), Kerman Univ Med Sci, Afzalipoor Fac Med, Dept Clin Biochem, Kerman, Iran.; Sahebkar, A (corresponding author), Mashhad Univ Med Sci, Pharmaceut Technol Inst, Biotechnol Res Ctr, Mashhad, Iran.; Sahebkar, A (corresponding author), Mashhad Univ Med Sci, Appl Biomed Res Ctr, Mashhad, Iran.
EM M.Sadeghipour65@yahoo.com; amir_saheb2000@yahoo.com
RI Mafi, Alireza/AAT-6866-2021; Mohammad-Sadeghipour, Maryam/AAX-6052-2021;
   Sahebkar, Amirhossein/B-5124-2018
FU Kerman University of Medical Sciences (KUMS) of Iran; Isfahan University
   of Medical Sciences (IUMS), Isfahan, Iran
FX The authors thank the Kerman University of Medical Sciences (KUMS) of
   Iran and Isfahan University of Medical Sciences (IUMS), Isfahan, Iran,
   for their cooperation.
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NR 139
TC 1
Z9 1
U1 1
U2 15
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1389-2037
EI 1875-5550
J9 CURR PROTEIN PEPT SC
JI Curr. Protein Pept. Sci.
PY 2024
VL 25
IS 1
BP 59
EP 70
DI 10.2174/1389203724666230822085951
PG 12
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA HU5Q6
UT WOS:001162037200001
PM 37608655
DA 2025-06-11
ER

PT J
AU Qian, X
   Li, XJ
   Tan, L
   Lee, JH
   Xia, Y
   Cai, QS
   Zheng, YH
   Wang, HX
   Lorenzi, PL
   Lu, ZM
AF Qian, Xu
   Li, Xinjian
   Tan, Lin
   Lee, Jong-Ho
   Xia, Yan
   Cai, Qingsong
   Zheng, Yanhua
   Wang, Hongxia
   Lorenzi, Philip L.
   Lu, Zhimin
TI Conversion of PRPS Hexamer to Monomer by AMPK-Mediated Phosphorylation
   Inhibits Nucleotide Synthesis in Response to Energy Stress
SO CANCER DISCOVERY
LA English
DT Article
ID ACTIVATED PROTEIN-KINASE; NOVO PYRIMIDINE SYNTHESIS; ENZYMATIC
   SYNTHESIS; METABOLIC SYNDROME; BETA-CATENIN; CANCER; HOMEOSTASIS;
   SYNTHETASE; APOPTOSIS; GROWTH
AB Tumors override energy stress to grow. However, how nucleotide synthesis is regulated under energy stress is unclear. We demonstrate here that glucose deprivation or hypoxia results in the AMPK-mediated phosphorylation of phosphoribosyl pyrophosphate synthetase 1 (PRPS1) S180 and PRPS2 S183, leading to conversion of PRPS hexamers to monomers and thereby inhibiting PRPS1/2 activity, nucleotide synthesis, and nicotinamide adenine dinucleotide (NAD) production. Knock-in of nonphosphorylatable PRPS1/2 mutants, which have uninhibited activity, in brain tumor cells under energy stress exhausts cellular ATP and NADPH and increases reactive oxygen species levels, thereby promoting cell apoptosis. The expression of those mutants inhibits brain tumor formation and enhances the inhibitory effect of the glycolysis inhibitor 2-deoxy-D-glucose on tumor growth. Our findings highlight the significance of recalibrating tumor cell metabolism by fine-tuning nucleotide and NAD synthesis in tumor growth. (c) 2017 AACR.
C1 [Qian, Xu; Li, Xinjian; Lee, Jong-Ho; Xia, Yan; Cai, Qingsong; Zheng, Yanhua; Lu, Zhimin] Univ Texas MD Anderson Canc Ctr, Brain Tumor Ctr, Houston, TX 77030 USA.
   [Qian, Xu; Li, Xinjian; Lee, Jong-Ho; Xia, Yan; Cai, Qingsong; Zheng, Yanhua; Lu, Zhimin] Univ Texas MD Anderson Canc Ctr, Dept Neurooncol, Houston, TX 77030 USA.
   [Tan, Lin; Lorenzi, Philip L.] Univ Texas MD Anderson Canc Ctr, Dept Bioinformat & Computat Biol, Houston, TX 77030 USA.
   [Tan, Lin; Lorenzi, Philip L.] Univ Texas MD Anderson Canc Ctr, Prote & Metab Core Facil, Houston, TX 77030 USA.
   [Wang, Hongxia] Shanghai Jiao Tong Univ, Inst Cell Metab & Dis, Shanghai Gen Hosp, Shanghai Key Lab Pancreat Canc,Sch Med, Shanghai, Peoples R China.
   [Lu, Zhimin] Univ Texas MD Anderson Canc Ctr, Dept Mol & Cellular Oncol, Houston, TX 77030 USA.
   [Lu, Zhimin] Univ Texas MD Anderson Canc Ctr, Canc Biol Program, UT Hlth Grad Sch Biomed Sci, Houston, TX 77030 USA.
C3 University of Texas System; UTMD Anderson Cancer Center; University of
   Texas System; UTMD Anderson Cancer Center; University of Texas System;
   UTMD Anderson Cancer Center; University of Texas System; UTMD Anderson
   Cancer Center; Shanghai Jiao Tong University; University of Texas
   System; UTMD Anderson Cancer Center; University of Texas System; UTMD
   Anderson Cancer Center
RP Lu, ZM (corresponding author), Univ Texas MD Anderson Canc Ctr, 1515 Holcombe Blvd,Unit 1002, Houston, TX 77030 USA.
EM zhiminlu@mdanderson.org
RI Lu, Zhimin/LZF-0860-2025; Wang, Hongxia/AAU-5674-2021
FU National Institute of Neurological Disorders and Stroke [R01 NS089754];
   National Cancer Institute [2R01 CA109035, R01 CA169603]; Brain Cancer
   SPORE [2P50 CA127001]; MD Anderson's Cancer Center Support Grant
   [CA016672]; National Natural Science Foundation of China (NSFC)
   [816228011, 81572499, 81572700]
FX This work was supported by National Institute of Neurological Disorders
   and Stroke grant R01 NS089754 (Z. Lu), National Cancer Institute grants
   2R01 CA109035 (Z. Lu) and R01 CA169603 (Z. Lu), 2P50 CA127001 (Brain
   Cancer SPORE), MD Anderson's Cancer Center Support Grant CA016672, and
   the National Natural Science Foundation of China (NSFC) 816228011 (H.
   Wang), 81572499, and 81572700. Z. Lu is a Ruby E. Rutherford
   Distinguished Professor.
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NR 52
TC 63
Z9 69
U1 3
U2 27
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 2159-8274
EI 2159-8290
J9 CANCER DISCOV
JI Cancer Discov.
PD JAN
PY 2018
VL 8
IS 1
BP 94
EP 107
DI 10.1158/2159-8290.CD-17-0712
PG 14
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA FS1PR
UT WOS:000419549800026
PM 29074724
OA Green Accepted, Green Submitted, Bronze
DA 2025-06-11
ER

PT J
AU Tomaipitinca, L
   Mandatori, S
   Mancinelli, R
   Giulitti, F
   Petrungaro, S
   Moresi, V
   Facchiano, A
   Ziparo, E
   Gaudio, E
   Giampietri, C
AF Tomaipitinca, Luana
   Mandatori, Sara
   Mancinelli, Romina
   Giulitti, Federico
   Petrungaro, Simonetta
   Moresi, Viviana
   Facchiano, Antonio
   Ziparo, Elio
   Gaudio, Eugenio
   Giampietri, Claudia
TI The Role of Autophagy in Liver Epithelial Cells and Its Impact on
   Systemic Homeostasis
SO NUTRIENTS
LA English
DT Review
DE autophagy; liver; lipid droplets; metabolism; oxidative stress; cancer
ID OXIDATIVE STRESS; ENDOTHELIAL-CELL; ER STRESS; CHOLANGIOCYTE AUTOPHAGY;
   HEPATIC AUTOPHAGY; SHEAR-STRESS; MELANOMA; DISEASE; PROTEIN; OBESITY
AB Autophagy plays a role in several physiological and pathological processes as it controls the turnover rate of cellular components and influences cellular homeostasis. The liver plays a central role in controlling organisms' metabolism, regulating glucose storage, plasma proteins and bile synthesis and the removal of toxic substances. Liver functions are particularly sensitive to autophagy modulation. In this review we summarize studies investigating how autophagy influences the hepatic metabolism, focusing on fat accumulation and lipids turnover. We also describe how autophagy affects bile production and the scavenger function within the complex homeostasis of the liver. We underline the role of hepatic autophagy in counteracting the metabolic syndrome and the associated cardiovascular risk. Finally, we highlight recent reports demonstrating how the autophagy occurring within the liver may affect skeletal muscle homeostasis as well as different extrahepatic solid tumors, such as melanoma.
C1 [Tomaipitinca, Luana; Mandatori, Sara; Mancinelli, Romina; Giulitti, Federico; Petrungaro, Simonetta; Moresi, Viviana; Ziparo, Elio; Gaudio, Eugenio; Giampietri, Claudia] Sapienza Univ Rome, Dept Anat Histol Forens Med & Orthoped Sci, I-00161 Rome, Italy.
   [Facchiano, Antonio] IRCCS, IDI, Mol Oncol Lab, I-00167 Rome, Italy.
C3 Sapienza University Rome; IRCCS Istituto Dermopatico dell'Immacolata
   (IDI)
RP Giampietri, C (corresponding author), Sapienza Univ Rome, Dept Anat Histol Forens Med & Orthoped Sci, I-00161 Rome, Italy.
EM luana.tomaipitinca@uniroma1.it; sara.mandatori@uniroma1.it;
   romina.mancinelli@uniroma1.it; federico.giulitti@uniroma1.it;
   simonetta.petrungaro@uniroma1.it; viviana.moresi@uniroma1.it;
   a.facchiano@idi.it; elio.ziparo@uniroma1.it; eugenio.gaudio@uniroma1.it;
   claudia.giampietri@uniroma1.it
RI Facchiano, Antonio/J-4744-2012; Tomaipitinca, Luana/AAC-2165-2019;
   Moresi, Viviana/N-7977-2013; Mancinelli, Romina/Y-4540-2018; Facchiano,
   Antonio/K-5984-2016
OI Giampietri, Claudia/0000-0002-5025-5365; Moresi,
   viviana/0000-0003-1912-0339; Mancinelli, Romina/0000-0003-2040-0581;
   Tomaipitinca, Luana/0000-0002-3862-7787; Mandatori,
   Sara/0000-0002-4666-2021; Facchiano, Antonio/0000-0002-4243-2392;
   petrungaro, simonetta/0000-0001-7283-4977
FU Ricerca Scientifica Sapienza 2015 grant; Ricerca Scientifica Sapienza
   2018 grant; "Cooperation with developing countries Sapienza 2017"
FX This research was funded by "Ricerca Scientifica Sapienza 2015 and 2018"
   grants to E.Z. and C.G. and by "Cooperation with developing countries
   Sapienza 2017" grant to C.G.
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NR 129
TC 21
Z9 22
U1 2
U2 8
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 2072-6643
J9 NUTRIENTS
JI Nutrients
PD APR
PY 2019
VL 11
IS 4
AR 827
DI 10.3390/nu11040827
PG 19
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA HX9SX
UT WOS:000467749800120
PM 30979078
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Fachin, A
   Silva, RKS
   Noschang, CG
   Pettenuzzo, L
   Bertinetti, L
   Billodre, MN
   Peres, W
   Busnello, F
   Dalmaz, C
AF Fachin, Andrelisa
   S. Silva, Rachel Krolow
   Noschang, Cristie G.
   Pettenuzzo, Leticia
   Bertinetti, Liane
   Billodre, Mauro Nor
   Peres, William
   Busnello, Fernanda
   Dalmaz, Carla
TI Stress effects on rats chronically receiving a highly palatable diet are
   sex-specific
SO APPETITE
LA English
DT Article
DE Chronic stress; Palatable diet; Chocolate; Sex; Abdominal fat; Insulin;
   Plasma lipids
ID CHRONIC RESTRAINT STRESS; FEEDING-BEHAVIOR; METABOLIC SYNDROME;
   PLASMA-GLUCOSE; LEPTIN; FEMALE; GLUCOCORTICOIDS; OBESITY;
   NEUROENDOCRINE; CHOLESTEROL
AB The stress response is known to lead to behavioral and metabolic changes. Exposure to chronic stress can promote the development of physiological and behavioral dysfunctions, including alterations in feeding behavior. The aim of this study was to verify whether chronic restraint stress alters the consumption of a highly palatable, highly caloric diet (chocolate), chronically offered to the animals. Male rats ate more chocolate than females. and they also exhibited a higher weight gain, abdominal fat deposition, and higher plasma levels of total cholesterol, LDL-cholesterol and glucose. The stress exposure decreased body weight, increased adrenal weight and decreased plasma insulin levels. Overall, female rats had lower plasma insulin levels and chocolate consumption prevented the increased adrenal :gland weight after exposure to chronic stress, suggesting a reduction of stress effects induced by palatable food consumption. Taken together, these results suggest a peculiar metabolic pattern, related to energy store and expenditure, in stressed animals receiving a palatable diet. Since these effects were sex-specific, we may also propose that females and males subjected to restraint stress and chocolate consumption are differentially affected. (c) 2008 Elsevier Ltd. All rights reserved.
C1 [Fachin, Andrelisa; S. Silva, Rachel Krolow; Noschang, Cristie G.; Pettenuzzo, Leticia; Bertinetti, Liane; Billodre, Mauro Nor; Peres, William; Dalmaz, Carla] Univ Fed Rio Grande do Sul, Dept Bioquim, Inst Ciencias Basicas Saude, BR-90035003 Porto Alegre, RS, Brazil.
   [Fachin, Andrelisa; Busnello, Fernanda] FFFCMPA, Nutr, Porto Alegre, RS, Brazil.
   [Peres, William] Univ Catolica Pelotas, Dept Biochem, Pelotas, RS, Brazil.
C3 Universidade Federal do Rio Grande do Sul; Universidade Federal de
   Pelotas; Universidade Catolica de Pelotas
RP Dalmaz, C (corresponding author), Univ Fed Rio Grande do Sul, Dept Bioquim, Inst Ciencias Basicas Saude, Ramiro Barcelos 2600 Anexo Lab 11, BR-90035003 Porto Alegre, RS, Brazil.
EM carladalmaz@yahoo.com.br
RI dalmaz, carla/M-2069-2014; Peres, William/ABG-7413-2021; Busnello,
   Fernanda/AEX-2991-2022; bertinetti, luca/M-8242-2016; Pettenuzzo,
   Leticia/N-9293-2017
OI Michielin Busnello, Fernanda/0000-0001-9091-142X; bertinetti,
   luca/0000-0002-4666-9610; Pettenuzzo, Leticia/0000-0001-6740-6177;
   Dalmaz, Carla/0000-0001-5397-2792
FU National Research Council of Brazil (CNPq); FAPERGS-PRONEX; FINEP/Rede
   IBN [01.06.0842-00]
FX National Research Council of Brazil (CNPq), FAPERGS-PRONEX and
   FINEP/Rede IBN 01.06.0842-00.
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NR 53
TC 21
Z9 25
U1 0
U2 11
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 0195-6663
EI 1095-8304
J9 APPETITE
JI Appetite
PD NOV
PY 2008
VL 51
IS 3
BP 592
EP 598
DI 10.1016/j.appet.2008.04.016
PG 7
WC Behavioral Sciences; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Behavioral Sciences; Nutrition & Dietetics
GA 358PV
UT WOS:000259930900026
PM 18524415
DA 2025-06-11
ER

PT J
AU Godala, M
   Materek-Kusmierkiewicz, I
   Moczulski, D
   Rutkowski, M
   Szatko, F
   Gaszynska, E
   Tokarski, S
   Kowalski, J
AF Godala, Malgorzata
   Materek-Kusmierkiewicz, Izabela
   Moczulski, Dariusz
   Rutkowski, Maciej
   Szatko, Franciszek
   Gaszynska, Ewelina
   Tokarski, Slawomir
   Kowalski, Jan
TI The risk of plasma vitamin A, C, E and D deficiency in patients with
   metabolic syndrome: A case-control study
SO ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE
LA English
DT Article
DE metabolic syndrome; antioxidant vitamins; vitamin D deficiency
ID HYPOVITAMINOSIS-D; OXIDATIVE STRESS; ANTIOXIDANT CONCENTRATIONS;
   SUPPLEMENTATION; DIETARY; CAROTENOIDS; POPULATION; DISEASE; ADULTS;
   HEALTH
AB Background. The increasing incidence of metabolic diseases such as obesity or diabetes have made them a major public health problem. Increasing oxidative stress induced by reactive oxygen species, which initiate the oxidative adverse changes in the cell, is mentioned, among other risk factors, to underlie these diseases. Vitamin A, C and E are listed among the non-enzymatic mechanisms counteracting this phenomenon. Vitamin D deficiency is also associated with cardiovascular diseases.
   Objectives. The aim of the study was to assess the risk of vitamin A, C, E and D deficit in the plasma of metabolic syndrome (MS) patients.
   Material and methods. The study included 191 patients with MS and 98 subjects without MS. Log-linear analysis was used in the assessment of mutual interactions between the vitamin concentration and the analysis of classification by ROC curves to predict the frequency of vitamin deficiency in MS patients.
   Results. A correlation was found between the plasma level of vitamins in the group of MS patients. Vitamin A concentration correlated with that of vitamin C (r = 0.51, p = 0.0000), vitamin D (r = 0.49, p = 0.0000) and E (r = 0.32, p = 0.0001). The plasma level of vitamin D correlated with the level of vitamin E (r = 0.46, p = 0.00000) and vitamin C (r = 0.37, p = 0.0000). Regression analysis showed a correlation between the concentration of the tested vitamins in patients with MS. Interactions were observed between vitamins C and A and between C and D. HDL cholesterol level was lower in patients with vitamin A deficiency compared to patients with its normal level.
   Conclusions. The plasma levels of vitamin A, C, E and D were significantly lower in patients with MS than in healthy subjects and they mutually correlated with each other. The normalization of glucose and HDL level may contribute to the regulation of the concentration of vitamin A in patients with MS.
C1 [Godala, Malgorzata] Med Univ Lodz, Dept Nutr & Epidemiol, Chair Hyg & Epidemiol, Lodz, Poland.
   [Materek-Kusmierkiewicz, Izabela; Moczulski, Dariusz] Med Univ Lodz, Dept Internal Med & Nephrodiabetol, Chair Internal Dis & Cardiol, Lodz, Poland.
   [Rutkowski, Maciej] Med Univ Lodz, Dept Mil Toxicol & Radiol Protect, Lodz, Poland.
   [Szatko, Franciszek; Gaszynska, Ewelina] Med Univ Lodz, Chair Hyg & Epidemiol, Dept Hyg & Hlth Promot, Lodz, Poland.
   [Tokarski, Slawomir] Univ Rzeszow, Fac Med, Rzeszow, Poland.
   [Kowalski, Jan] Med Univ Lodz, Dept Internal & Infect Dis, Lodz, Poland.
C3 Medical University Lodz; Medical University Lodz; Medical University
   Lodz; Medical University Lodz; University of Rzeszow; Medical University
   Lodz
RP Godala, M (corresponding author), Med Univ Lodz, Dept Nutr & Epidemiol, Chair Hyg & Epidemiol, Lodz, Poland.
EM malgorzata.godala@umed.lodz.pl
RI Godala, Malgorzata/S-9597-2016; Gaszynska, Ewelina/S-9946-2016;
   Kowalski, Jan/HDM-3504-2022
OI Tokarski, Slawomir/0000-0003-1153-0667; Moczulski,
   Dariusz/0000-0002-0926-9909; Godala, Malgorzata/0000-0003-3579-8537;
   Materek-Kusmierkiewicz, Izabela/0000-0001-5912-4516; Gaszynska,
   Ewelina/0000-0001-7568-3502
FU Medical University of Lodz [502-03/6-024-02/502-64-050]
FX The study was financed by the Medical University of Lodz (research task
   No: 502-03/6-024-02/502-64-050).
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NR 30
TC 53
Z9 59
U1 0
U2 11
PU WROCLAW MEDICAL UNIV
PI WROCLAW
PA UL K MARCINKOWSKIEGO 2-6, WROCLAW, 50-368, POLAND
SN 1899-5276
EI 2451-2680
J9 ADV CLIN EXP MED
JI Adv. Clin. Exp. Med.
PD JUL
PY 2017
VL 26
IS 4
BP 581
EP 586
DI 10.17219/acem/62453
PG 6
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA FF1MN
UT WOS:000408663700004
PM 28691410
OA gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Durak, A
   Bitirim, CV
   Turan, B
AF Durak, Aysegul
   Bitirim, Ceylan, V
   Turan, Belma
TI Titin and CK2α are New Intracellular Targets in Acute Insulin
   Application-Associated Benefits on Electrophysiological Parameters of
   Left Ventricular Cardiomyocytes From Insulin-Resistant Metabolic
   Syndrome Rats
SO CARDIOVASCULAR DRUGS AND THERAPY
LA English
DT Article
DE Heart function; Left ventricular cardiomyocytes; Insulin resistance;
   Metabolic syndrome; Nitrosative stress; Cardiac electrophysiology
ID OXIDATIVE STRESS; HEART-RATE; CARDIOVASCULAR-DISEASE; CARDIAC
   DYSFUNCTION; DIABETES-MELLITUS; MESSENGER-RNA; RISK-FACTORS; GLUCOSE;
   REPERFUSION; EXPRESSION
AB Background Previous studies have demonstrated that a high-carbohydrate intake could induce metabolic syndrome (MetS) in male rats with marked cardiac functional abnormalities. In addition, studies mentioned some benefits of insulin application on these complications, but there are considerable disagreements among their findings. Therefore, we aimed to extend our knowledge on the in-vitro influence of insulin on left ventricular dysfunction and also in the isolated cardiomyocytes from MetS rats. Results At the organ function level, an acute insulin application (100-nM) provided an important beneficial effect on the left ventricular developed pressure in MetS rats. Furthermore, to treat the freshly isolated cardiomyocytes from MetS rats with insulin provided marked recoveries in elevated resting intracellular Ca2+-level, as well as significant prevention of prolonged action potential through an augmentation in depressed K+-channel currents. Insulin also normalized the cellular levels of increased ROS and phosphorylation of PKC alpha, together with normalizations of apoptotic markers in MetS cardiomyocytes through the insulin-mediated regulation of phospho-Akt. Since not only elevated PKC alpha-activity but also reductions in phospho-Akt are key modulators of titin-based cardiomyocyte stiffening in hyperglycemia, insulin treatment of the cardiomyocytes prevented the activation of titin via the above pathways. Furthermore, CK2 alpha-activation and NOS-phosphorylation could be prevented with insulin treatment. Mechanistically, we found that impaired insulin signaling and elevated PKC alpha and CK2 alpha activities, as well as depressed Akt phosphorylation, are key modulators of titin-based cardiomyocyte stiffening in MetS rats. Conclusion We propose that restoring normal kinase activities and also increases in phospho-Akt by insulin can contribute marked recoveries in MetS heart function, indicating a promising approach to modulate titin-associated factors in heart dysfunction associated with type-2 diabetes mellitus.
   Graphical
C1 [Durak, Aysegul; Turan, Belma] Ankara Univ, Fac Med, Dept Biophys, Ankara, Turkey.
   [Bitirim, Ceylan, V] Ankara Univ, Stem Cell Inst, Ankara, Turkey.
C3 Ankara University; Ankara University
RP Turan, B (corresponding author), Ankara Univ, Fac Med, Dept Biophys, Ankara, Turkey.
EM belma.turan@medicine.ankara.edu.tr
RI TURAN, Belma/AAG-8084-2020; BITIRIM, VERDA/A-6731-2018; durak,
   aysegul/AAA-7647-2022
OI Bitirim, Ceylan Verda/0000-0002-7979-0679
FU TUBITAK [SBAG214S254]
FX This study was funded by TUBITAK SBAG214S254 to Belma Turan.
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NR 82
TC 9
Z9 9
U1 0
U2 3
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0920-3206
EI 1573-7241
J9 CARDIOVASC DRUG THER
JI Cardiovasc. Drugs Ther.
PD AUG
PY 2020
VL 34
IS 4
BP 487
EP 501
DI 10.1007/s10557-020-06974-2
EA MAY 2020
PG 15
WC Cardiac & Cardiovascular Systems; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Pharmacology & Pharmacy
GA MF1HU
UT WOS:000530768600001
PM 32377826
DA 2025-06-11
ER

PT J
AU Coskun, ZM
AF Coskun, Zeynep Mine
TI ER Stress Amelioration by Saxagliptin Protects the Liver Against
   Fructose-induced Insulin Resistance
SO ARCHIVES OF MEDICAL RESEARCH
LA English
DT Article
DE ER stress; Immunohistochemistry; Inflammation; Insulin resistance;
   Saxagliptin
ID ENDOPLASMIC-RETICULUM STRESS; METABOLIC SYNDROME; OXIDATIVE STRESS;
   MODEL
AB Background/Aim. The study is aimed to demonstrate whether saxagliptin treatment may reduce endoplasmic reticulum (ER) stress, oxidative damage, and inflammation in the liver of fructose-induced insulin resistance (IR) rats.
   Material and Methods. Twenty-eight rats were divided as control, IR, saxagliptin treatment (ST) and IR+ST groups. IR caused by fructose (10%) administration for 10 weeks and, ST was administered for 15 d. The liver tissues were obtained from rats. ER stress markers were analyzed using Real-Time PCR. Oxidative stress was measured. The inflammation in the liver was detected by the streptavidin-biotin immunostaining method.
   Results. The values of total oxidant/antioxidant status were the same between control and IR rats. The numbers of IL-6, NF-kappa B and PPAR gamma immune(+) cells showed significant changes in the liver among four groups. The increased mRNA expression levels of ER stress and apoptosis markers as GRP78, PERK, IRE1 alpha, ATF-4 and -6, CHOP, Caspase-3, -8, -9 and -12 in IR reduced with ST.
   Conclusion. These findings indicate that saxagliptin treatment may ameliorate IR by reducing ER stress rather than inflammation and oxidative stress in the liver. (C) 2020 IMSS. Published by Elsevier Inc.
C1 [Coskun, Zeynep Mine] Demiroglu Bilim Univ, Fac Arts & Sci, Dept Mol Biol & Genet, TR-34394 Istanbul, Turkey.
C3 Demiroglu Bilim University
RP Coskun, ZM (corresponding author), Demiroglu Bilim Univ, Fac Arts & Sci, Dept Mol Biol & Genet, TR-34394 Istanbul, Turkey.
EM zeynepminecoskun@gmail.com
RI coskun, zeynep/AAV-1778-2021
OI COSKUN YAZICI, Zeynep Mine/0000-0003-4791-6537
FU Istanbul University; Cerrahpasa; Demiroglu Bilim University
FX The author thanks Istanbul University, Cerrahpasa and Demiroglu Bilim
   University for their supports.
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NR 42
TC 5
Z9 5
U1 0
U2 2
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0188-4409
EI 1873-5487
J9 ARCH MED RES
JI Arch. Med. Res.
PD MAY
PY 2020
VL 51
IS 4
BP 303
EP 309
DI 10.1016/j.arcmed.2020.03.007
PG 7
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA LW0CE
UT WOS:000538813800003
PM 32223915
DA 2025-06-11
ER

PT J
AU Makhtoomi, M
   Shateri, Z
   Mashoufi, A
   Nouri, M
   Honarvar, B
   Keshani, P
AF Makhtoomi, Maede
   Shateri, Zainab
   Mashoufi, Ava
   Nouri, Mehran
   Honarvar, Behnam
   Keshani, Parisa
TI The association between dietary polyphenol intake and the odds of
   metabolic syndrome
SO SCIENTIFIC REPORTS
LA English
DT Article
DE Polyphenols; Metabolic syndrome; Waist circumference; Triglyceride;
   Fasting blood sugar; High-density lipoprotein cholesterol; Blood
   pressure
ID CARDIOVASCULAR RISK-FACTORS; MEDITERRANEAN DIET; INSULIN-RESISTANCE;
   OXIDATIVE STRESS; FLAVONOID INTAKE; GLYCEMIC CONTROL; METAANALYSIS;
   MECHANISMS; WOMEN; HEALTH
AB Oxidative stress plays a role in the pathophysiology of metabolic syndrome (MetS), and one of the most important features of polyphenols is their antioxidant properties. However, there is no universal consensus on the effectiveness of polyphenols in treating Mets. Therefore, the present study aimed to investigate the association between polyphenols and MetS in an Iranian sample. This cross-sectional study was conducted on an adult population sample from Shiraz, in southern Iran. MetS was calculated using the criteria of the Adult Treatment Panel III (ATP III), which defines MetS as the presence of three or more of the specified risk factors. A validated food frequency questionnaire (FFQ) was used to measure the participant's food intake. The association between polyphenol intake and the odds on MetS and its components was assessed using logistic regression. In both univariate and multivariate models, the association between polyphenol intake and the risk of MetS was not significant. However, after adjusting for potential confounders in the multivariate model, each unit change in flavonol, flavanone and isoflavones intake was associated with a lower, higher, and higher odds of MetS, respectively (flavonols: odds ratio (OR) = 0.926, 95% confidence interval (CI) 0.891-0.963, P < 0.001-flavanones: OR = 1.007, 95% CI: 1.001-1.014, P = 0.034-isoflavones: OR = 4.920, 95% CI: 1.057-22.894, P = 0.042). Additionally, no significant association was found between polyphenol intake and the risk of MetS components. However, in the multivariate model, after adjusting for potential confounders, a significant association was observed between polyphenol intake and lower odds of high waist circumference (OR = 0.998, 95% CI: 0.996-0.999, P = 0.032). The present study did not reveal a significant association between overall polyphenol intake and the odds of MetS. However, certain subclasses of polyphenols appear to be associated with the likelihood of MetS and its components.
C1 [Makhtoomi, Maede] Shiraz Univ, Med Sci, Student Res Comm, Shiraz, Iran.
   [Makhtoomi, Maede; Honarvar, Behnam; Keshani, Parisa] Shiraz Univ Med Sci, Inst Hlth, Hlth Policy Res Ctr, Shiraz, Iran.
   [Shateri, Zainab] Ilam Univ Med Sci, Sch Med, Dept Nutr & Biochem, Ilam, Iran.
   [Mashoufi, Ava] Shiraz Univ Med Sci, Dept Community Nutr, Sch Nutr & Food Sci, Shiraz, Iran.
   [Nouri, Mehran] Babol Univ Med Sci, Hlth Res Inst, Cellular & Mol Biol Res Ctr, Babol, Iran.
C3 Shiraz University; Shiraz University of Medical Science; Shiraz
   University of Medical Science; Babol University of Medical Sciences
RP Keshani, P (corresponding author), Shiraz Univ Med Sci, Inst Hlth, Hlth Policy Res Ctr, Shiraz, Iran.; Nouri, M (corresponding author), Babol Univ Med Sci, Hlth Res Inst, Cellular & Mol Biol Res Ctr, Babol, Iran.
EM mehran_nouri71@yahoo.com; parisa.keshani@gmail.com
RI Honarvar, Behnam/K-1623-2013
OI Shateri, Zainab/0000-0003-3725-6686
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NR 48
TC 1
Z9 1
U1 2
U2 2
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD OCT 26
PY 2024
VL 14
IS 1
AR 25559
DI 10.1038/s41598-024-77335-4
PG 10
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA K4P0V
UT WOS:001343699800015
PM 39462087
OA gold
DA 2025-06-11
ER

PT J
AU Simao, ANC
   Lozovoy, MAB
   Simao, TNC
   Venturini, D
   Barbosa, DS
   Dichi, JB
   Matsuo, T
   Cecchini, R
   Dichi, I
AF Simao, A. N. C.
   Lozovoy, M. A. B.
   Simao, T. N. C.
   Venturini, D.
   Barbosa, D. S.
   Dichi, J. B.
   Matsuo, T.
   Cecchini, R.
   Dichi, I.
TI Immunological and biochemical parameters of patients with metabolic
   syndrome and the participation of oxidative and nitroactive stress
SO BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
LA English
DT Article
DE Metabolic syndrome; Uric acid; Inflammation; Adiponectin; Nitric oxide;
   Lipoperoxidation
ID NITRIC-OXIDE METABOLITES; TUMOR-NECROSIS-FACTOR; URIC-ACID;
   INSULIN-RESISTANCE; OBESITY; INTERLEUKIN-6; ADIPONECTIN; MARKERS;
   INFLAMMATION; REDUCTION
AB Metabolic syndrome (MS) is a multifactorial disease involving inflammatory activity and endothelial dysfunction. The aim of the present study was to evaluate the relationship between the changes in lipoperoxidation, in immunological and biochemical parameters and in nitric oxide metabolite (NOx) levels in MS patients. Fifty patients with MS (4 males/46 females) and 50 controls (3 males/47 females) were studied. Compared to control (Mann-Whitney test), MS patients presented higher serum levels (P < 0.05) of fibrinogen: 314 (185-489) vs 262 (188-314) mg/dL, C-reactive protein (CRP): 7.80 (1.10-46.50) vs 0.70 (0.16-5.20) mg/dL, interleukin-6: 3.96 (3.04-28.18) vs 3.33 (2.55-9.63) pg/mL, uric acid: 5.45 (3.15-9.65) vs 3.81 (2.70-5.90) mg/dL, and hydroperoxides: 20,689 (19,076-67,182) vs 18,636 (15,926-19,731) cpm. In contrast, they presented lower (P < 0.05) adiponectin: 7.11 (3.19-18.22) vs 12.31 (9.11-27.27) mu g/mL, and NOx levels: 5.69 (2.36-8.18) vs 6.72 (5.14-12.43) mu M. NOx was inversely associated (Spearman's rank correlation) with body mass index (r = -0.2858, P = 0.0191), insulin resistance determined by the homeostasis model assessment (r = -0.2530, P = 0.0315), CRP (r = -0.2843, P = 0.0171) and fibrinogen (r = -0.2464, P = 0.0413), and positively correlated with hydroperoxides (r = 0.2506, P = 0.0408). In conclusion, NOx levels are associated with obesity, insulin resistance, oxidative stress, and inflammatory markers. The high uric acid levels together with reactive oxygen species generation may be responsible for the reduced NO levels, which in turn lead to endothelial dysfunction. The elevated plasma chemiluminescence reflecting both increased plasma oxidation and reduced antioxidant capacity may play a role in the MS mechanism.
C1 [Simao, A. N. C.; Venturini, D.; Barbosa, D. S.] Univ Estadual Londrina, Dept Patol Anal Clin & Toxicol, BR-86038440 Londrina, PR, Brazil.
   [Lozovoy, M. A. B.] Univ Norte Parana, Dept Anal Clin, Londrina, PR, Brazil.
   [Simao, T. N. C.] Univ Norte Parana, Dept Clin Nutr, Londrina, PR, Brazil.
   [Dichi, J. B.; Dichi, I.] Univ Estadual Londrina, Dept Clin Med, BR-86038440 Londrina, PR, Brazil.
   [Matsuo, T.] Univ Estadual Londrina, Dept Estat, BR-86038440 Londrina, PR, Brazil.
   [Cecchini, R.] Univ Estadual Londrina, Dept Ciencias Patol, BR-86038440 Londrina, PR, Brazil.
C3 Universidade Estadual de Londrina; University Norte Parana; University
   Norte Parana; Universidade Estadual de Londrina; Universidade Estadual
   de Londrina; Universidade Estadual de Londrina
RP Simao, ANC (corresponding author), Univ Estadual Londrina, Dept Patol Anal Clin & Toxicol, Ave Robert Koch 60, BR-86038440 Londrina, PR, Brazil.
EM deianame@yahoo.com.br
RI Venturini, Danielle/HPH-1330-2023; Lozovoy, Marcell/AAM-4897-2021;
   Simão, Andrea/AAM-4892-2021; Barbosa, Décio/AAE-6351-2019; Cecchini,
   Rubens/D-9811-2013
OI Cecchini, Rubens/0000-0001-9941-2344
FU CNPq
FX Research supported by CNPq.
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NR 33
TC 15
Z9 15
U1 0
U2 5
PU ASSOC BRAS DIVULG CIENTIFICA
PI RIBEIRAO PRETO
PA FACULDADE MEDICINA, CASA 10, 14049 RIBEIRAO PRETO, RIBEIRAO PRETO, SP
   14049, BRAZIL
SN 0100-879X
EI 1414-431X
J9 BRAZ J MED BIOL RES
JI Brazilian J. Med. Biol. Res.
PD JUL
PY 2011
VL 44
IS 7
BP 707
EP 712
DI 10.1590/S0100-879X2011007500069
PG 6
WC Biology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics; Research & Experimental
   Medicine
GA 804KC
UT WOS:000293651700015
PM 21625822
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Kiran, TR
   Otlu, O
   Karabulut, AB
AF Kiran, Tugba Raika
   Otlu, Onder
   Karabulut, Aysun Bay
TI Oxidative stress and antioxidants in health and disease
SO JOURNAL OF LABORATORY MEDICINE
LA English
DT Review
DE antioxidants; diseases; free radicals; nitrogen oxygen species;
   oxidative stress; reactive oxygen species
ID NITRIC-OXIDE; GLUTATHIONE-PEROXIDASE; FREE-RADICALS; MITOCHONDRIA;
   DAMAGE; MECHANISMS; GENERATION; ROS
AB The increase in the formation of reactive oxygen and reactive nitrogen species of endogenous or exogenous origin causes oxidative stress due to pro-oxidant and antioxidant imbalance that causes cellular damage in metabolism. This can increase inflammation of cells, apoptosis and necrosis, damage to DNA base damage, DNA and protein cross-links, lipid membrane peroxidation, and mitochondrial dysfunction. Antioxidants can be described as a system that protects biomolecules and the organism against the harmful effects of free radicals, reduces or repairs the damage done by reactive oxygen species (ROS) to the target molecule, and this is called antioxidant defense. It is known that the mechanisms caused by the increase in ROS resulting from oxidative stress are positively related to the pathology of many diseases such as cancer, metabolic syndrome, atherosclerosis, malaria, Alzheimer's disease, rheumatoid arthritis, neurodegenerative diseases and preeclampsia.
C1 [Kiran, Tugba Raika; Otlu, Onder] Malatya Turgut Ozal Univ, Med Biochem Dept, Fac Med, Malatya, Turkiye.
   [Karabulut, Aysun Bay] Ankara Yildirim Beyazit Univ, Med Biochem Dept, Fac Med, Ankara, Turkiye.
C3 Malatya Turgut Ozal University; Ankara Yildirim Beyazit University
RP Kiran, TR (corresponding author), Malatya Turgut Ozal Univ, Med Biochem Dept, Fac Med, Malatya, Turkiye.
EM raika.kiran@ozal.edu.tr
RI KIRAN, TUGBA/AAA-8224-2021; Otlu, Onder/W-3887-2018
OI KIRAN, TUGBA RAIKA/0000-0002-3724-0249; Otlu, Onder/0000-0001-5958-7609
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NR 96
TC 61
Z9 64
U1 27
U2 73
PU WALTER DE GRUYTER GMBH
PI BERLIN
PA GENTHINER STRASSE 13, D-10785 BERLIN, GERMANY
SN 2567-9430
EI 2567-9449
J9 J LAB MED
JI J. Lab. Med.
PD FEB 23
PY 2023
VL 47
IS 1
BP 1
EP 11
DI 10.1515/labmed-2022-0108
PG 11
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA S2DH9
UT WOS:001069321700001
OA gold
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Reddy, MTK
   Kolalapudi, SA
   Praveen, S
   Konala, S
   Rasajna, GL
   Khutate, SS
AF Reddy, M. Thanoj K.
   Kolalapudi, Seetharam A.
   Praveen, Seva
   Konala, Subhashini
   Rasajna, Gunnam L.
   Khutate, Saloni S.
TI Clinical and Laboratory Parameters of Metabolic Syndrome in Chronic
   Spontaneous Urticaria: A Cross-Sectional Study
SO INDIAN DERMATOLOGY ONLINE JOURNAL
LA English
DT Article
DE Chronic spontaneous urticaria; metabolic syndrome; oxidative stress
AB Background: Chronic spontaneous urticaria (CSU) appears to share some pathomechanisms with metabolic syndrome (MS), such as proinflammatory state, increased oxidative stress, changes in adipokine profile, and coagulation system activation. Aim and Objectives: To evaluate clinical and laboratory parameters of MS in CSU patients and to assess relationship of MS with duration and severity of CSU, Ig-E, thyroid-stimulating hormone (TSH), C-reactive protein (CRP), and autologous serum skin test (ASST). Materials and Methods: A hospital-based cross-sectional study was conducted on 131 CSU cases and 131 controls who were age- and sex-matched. Duration of the CSU and urticaria activity score (UAS) were noted. Waist circumference (WC), blood pressure, fasting blood sugar, high-density lipoprotein (HDL), triglycerides (TG), CRP, TSH, IgE, and ASST were noted. MS was considered according to Harmonization Asian criteria. Results: The percentage of patients with elevated clinical and laboratory parameters of MS was higher in cases compared to controls, in which WC, HDL, and TG were significantly elevated. MS was positive in 25.19% and 14.50% of cases and controls, respectively (P = 0.044). Cases with MS had a significant higher mean duration (16.60 months) than those without MS (8.81 months) (P = 0.004). MS was positive in 15.2%, 32.3%, and 36.4% of mild, moderate, and severe UAS patients, respectively (P = 0.095). Patients with increased TSH and CRP had a significantly higher percentage of MS (68.4% and 40.7%, respectively) than with normal TSH and CRP (15% and 19.4%, respectively) (P < 0.05), while it was not significant with respect to IgE and ASST. Limitations: Small sample size and it was a hospital-based study, therefore, all controls were from the patients attending our outpatient department only and could not be compared with the general population. Conclusion: MS is not uncommon in CSU patients. The duration of CSU, CRP levels, and TSH levels have a significant positive correlation with MS. Screening, along with regular surveillance of CSU patients, aids in the early detection of MS and minimizes the risk of cardiovascular disease.
C1 [Reddy, M. Thanoj K.; Kolalapudi, Seetharam A.; Praveen, Seva; Konala, Subhashini; Rasajna, Gunnam L.; Khutate, Saloni S.] GSL Med Coll & Gen Hosp, Dept Dermatol Venereol & Leprosy, Rajahmahendravaram 533296, Andhra Pradesh, India.
RP Konala, S (corresponding author), GSL Med Coll & Gen Hosp, Dept Dermatol Venereol & Leprosy, Rajahmahendravaram 533296, Andhra Pradesh, India.
EM subha.konala@gmail.com
FU IADVL postgraduate thesis research grant
FX Our study was supported by IADVL postgraduate thesis research grant.
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NR 15
TC 0
Z9 0
U1 0
U2 0
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, Maharashtra, INDIA
SN 2229-5178
EI 2249-5673
J9 INDIAN DERMATOL ONL
JI Indian Dermatol. Online J.
PD JAN-FEB
PY 2025
VL 16
IS 1
BP 105
EP 109
DI 10.4103/idoj.idoj_945_24
PG 5
WC Dermatology
WE Emerging Sources Citation Index (ESCI)
SC Dermatology
GA Q5C0R
UT WOS:001384847100025
PM 39850703
OA gold
DA 2025-06-11
ER

PT J
AU Zheng, NN
   Ding, XD
   Wei, D
   Dai, B
   Zheng, LY
   Sumi, R
   Hu, DH
   Jahane, R
   Sun, LN
AF Zheng, Ningning
   Ding, Xudong
   Wei, Dan
   Dai, Bo
   Zheng, Lanyan
   Sumi, Ryo
   Hu, Dahai
   Jahane, Rabita
   Sun, Luning
TI Therapeutic Effects of Coccomyxagloeobotrydiformis on the Metabolic
   Syndrome in Rats
SO CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
LA English
DT Article
DE Metabolic Syndrome; Cardiovascular Disease; Mitochondrial Respiratory
   Chain; Oxidative Stress
ID COCCOMYXA GLOEOBOTRYDIFORMIS; INSULIN-RESISTANCE; TROPOMODULIN1;
   EXPRESSION; LEIOMODIN; FILAMENTS; PATHWAY; HEART; END
AB Background/Aims: The metabolic syndrome (MS) is a cluster of metabolic changes that carry a high risk of cardiovascular disease (CVD). A newly discovered microalga, coccomyxagloeobotrydiformis (CGD), has been reported to improve ischemic stroke and metabolism-related indicators. We observed the therapeutic effects of CGD on MS and postulated the underlying mechanism. Methods: A diet-induced MS model in rats was used to observe the therapeutic effects of CGD on MS. Blood-glucose and lipid indices were measured using enzymatic colorimetric kits. A biologic data acquisition and analysis system (BL-420F) was used to evaluate cardiac function. Expression of mitochondrial respiratory chain (MRC) enzymes was measured by immunofluorescence staining. The proteins associated with oxidative stress, apoptosis and inflammation were detected by western blotting. Results: Body weight, abdominal circumference, fasting blood glucose, blood pressure as well as serum levels of total cholesterol, triglycerides and low-density lipoprotein-cholesterol were decreased whereas serum levels of high-density lipoprotein-cholesterol was increased in CGD-treated MS rats. CGD increased left-ventricular systolic pressure, left-ventricular end-diastolic pressure, left-ventricular systolic pressure maximum rate of increase and left-ventricular diastolic pressure maximum rate of decrease in MS rats with cardiovascular complications. CGD up-regulated expression of adenosine monophosphate-activated protein kinase and peroxisome proliferator activated receptor gamma coactivator 1-alpha in the heart, adipose tissue and skeletal muscle. Expression of the MRC subunits of ATPase 6, cytochrome b and succinate dehydrogenase complex, subunit-A was increased whereas that of uncoupling protein-2 decreased in different tissues. CGD showed anti-oxidation effects by increasing expression of superoxide dismutase and decreasing that of malondialdehyde. High expression of Bcl-2 and low expression of Bax and caspase-3 supported the anti-apoptotic effect of CGD on the cardiovascular complications of MS. Conclusion: CGD has a therapeutic effect on MS and associated cardiovascular complications by eliciting mitochondrial protection and having anti-oxidation and anti-apoptosis effects. CGD could be used for MS treatment. (c) 2018 The Author(s) Published by S. Karger AG, Basel
C1 [Zheng, Ningning; Sun, Luning] China Med Univ, Coll Basic Med Sci, Dept Pathophysiol, Shenyang, Liaoning, Peoples R China.
   [Ding, Xudong] China Med Univ, Shengjing Hosp, Dept Anesthesiol, Shenyang, Liaoning, Peoples R China.
   [Wei, Dan; Dai, Bo] China Med Univ, Grad Sch, Dept Pathophysiol, Shenyang, Liaoning, Peoples R China.
   [Zheng, Lanyan] China Med Univ, Coll Basic Med Sci, Dept Pathogen Biol, Shenyang, Liaoning, Peoples R China.
   [Sumi, Ryo] Nikken Sohonsha Corp Japan, Tanaka Mem Lab, Gifu, Japan.
   [Hu, Dahai] Univ Sci & Technol China, Sch Management, Dept Stat & Finance, Hefei, Anhui, Peoples R China.
   [Jahane, Rabita] China Med Univ, Int Educ Sch, Shenyang, Liaoning, Peoples R China.
C3 China Medical University; China Medical University; China Medical
   University; China Medical University; Chinese Academy of Sciences;
   University of Science & Technology of China, CAS; China Medical
   University
RP Sun, LN (corresponding author), Coll Basic Med Sci, Dept Pathophysiol, 77 Puhe Rd, Shenyang 110122, Liaoning, Peoples R China.
EM lnsun@cmu.edu.cn
RI Zheng, Ningning/KHU-0389-2024; yang, xuekang/IUP-2564-2023
FU Nikken Sohonsha Corporation of Japan (FDN) [201701]
FX This research was funded by Nikken Sohonsha Corporation of Japan
   (FDN#201701).
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NR 46
TC 5
Z9 5
U1 1
U2 10
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1015-8987
EI 1421-9778
J9 CELL PHYSIOL BIOCHEM
JI Cell. Physiol. Biochem.
PY 2018
VL 48
IS 4
BP 1519
EP 1529
DI 10.1159/000492262
PG 11
WC Cell Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Physiology
GA GS4LR
UT WOS:000443615100010
PM 30071531
OA gold
DA 2025-06-11
ER

PT J
AU Lee, SY
   Chen, SL
   Chang, YH
   Chen, PS
   Huang, SY
   Tzeng, NS
   Wang, CL
   Wang, LJ
   Lee, IH
   Wang, TY
   Chen, KC
   Yang, YK
   Hong, JS
   Lu, RB
AF Lee, S. -Y.
   Chen, S. -L.
   Chang, Y. -H.
   Chen, P. -S.
   Huang, S. -Y.
   Tzeng, N. -S.
   Wang, C. -L.
   Wang, L. -J.
   Lee, I. -H.
   Wang, T. -Y.
   Chen, K. -C.
   Yang, Y. -K.
   Hong, J. -S.
   Lu, R. -B.
TI Correlation of plasma brain-derived neurotrophic factor and metabolic
   profiles in drug-naive patients with bipolar II disorder after a
   twelve-week pharmacological intervention
SO ACTA PSYCHIATRICA SCANDINAVICA
LA English
DT Article
DE bipolar II disorder; body mass index; metabolic syndrome; brain-derived
   neurotrophic factor
ID FACTOR BDNF; DEPRESSED-PATIENTS; HUMAN PLATELETS; MOOD EPISODES; SERUM;
   LITHIUM; NGF; RESTRICTION; PLASTICITY; GENDER
AB ObjectiveBrain-derived neurotrophic factor (BDNF) is thought to be involved in the pathophysiology of bipolar disorder (BD) and metabolic syndrome. We investigated the correlation between plasma BDNF with mood symptoms and metabolic indices in patients with BD-II over a 12-week pharmacological intervention.
   MethodDrug-naive patients with BD-II (n=117) were recruited. Metabolic profiles [cholesterol, triglyceride, HbA1C, fasting serum glucose, body mass index (BMI)] and plasma BDNF wtrun "tblautotrun "tblsctrun "tbl_contere measured at baseline and 2, 8, and 12weeks after beginning medication. To adjust within-subject dependence over repeated assessments, multiple linear regressions with generalized estimating equation methods were used.
   ResultsSeventy-six (65.0%) patients completed the intervention. Plasma BDNF levels were significantly associated with BMI (P=9.6E-5), low-density lipoprotein (P=0.034) and total (P=0.001) cholesterol, but not with the Hamilton Depression Rating Scale-17 and Young Mania Rating Scale scores over the 12-week treatment.
   ConclusionWe found initial evidence of a positive correlation between plasma BDNF levels and BMI, low-density lipoprotein and total cholesterol in drug-naive patients with BD-II. The specific function of BDNF in regulating and maintaining peripheral metabolic health requires additional investigation.
C1 [Lee, S. -Y.] Kaohsiung Vet Gen Hosp, Dept Psychiat, Kaohsiung, Taiwan.
   [Lee, S. -Y.; Chen, S. -L.; Chang, Y. -H.; Chen, P. -S.; Wang, C. -L.; Lee, I. -H.; Chen, K. -C.; Yang, Y. -K.; Lu, R. -B.] Natl Cheng Kung Univ, Dept Psychiat, Coll Med, Tainan 70428, Taiwan.
   [Chen, S. -L.; Lu, R. -B.] Kaohsiung Med Univ, Sch Med, Dept Neurol, Kaohsiung, Taiwan.
   [Chang, Y. -H.] Natl Cheng Kung Univ, Inst Allied Hlth Sci, Coll Med & Hosp, Tainan 70428, Taiwan.
   [Huang, S. -Y.; Tzeng, N. -S.] Triserv Gen Hosp, Natl Def Med Ctr, Dept Psychiat, Taipei, Taiwan.
   [Wang, L. -J.] Kaohsiung Chang Gung Mem Hosp, Dept Child & Adolescent Psychiat, Kaohsiung, Taiwan.
   [Wang, L. -J.] Chang Gung Univ, Coll Med, Kaohsiung, Taiwan.
   [Wang, T. -Y.] Tainan Hosp, Dept Hlth, Dept Psychiat, Tainan, Taiwan.
   [Chen, K. -C.; Lu, R. -B.] Natl Cheng Kung Univ Hosp, Dept Psychiat, Yunlin, Taiwan.
   [Yang, Y. -K.] Natl Cheng Kung Univ, Addict Res Ctr, Tainan 70428, Taiwan.
   [Hong, J. -S.] NIEHS, Lab Toxicol & Pharmacol, NIH, Res Triangle Pk, NC 27709 USA.
   [Lu, R. -B.] Inst Behav Med, Tainan, Taiwan.
   [Lu, R. -B.] Natl Hlth Res Inst, Ctr Neuropsychiat Res, Miaoli, Taiwan.
C3 Kaohsiung Veterans General Hospital; National Cheng Kung University;
   Kaohsiung Medical University; National Cheng Kung University; National
   Defense Medical Center; Tri-Service General Hospital; Chang Gung
   Memorial Hospital; Chang Gung University; National Cheng Kung
   University; National Cheng Kung University Hospital; National Cheng Kung
   University; National Institutes of Health (NIH) - USA; NIH National
   Institute of Environmental Health Sciences (NIEHS); National Health
   Research Institutes - Taiwan
RP Lu, RB (corresponding author), Natl Cheng Kung Univ, Inst Behav Med, Dept Psychiat, Addict Ctr,Coll Med & Hosp, 138 Sheng Li Rd, Tainan 70428, Taiwan.
EM rblu@mail.ncku.edu.tw
RI Chen, Chih-Ping/D-1416-2014; Chen, Shiou/AEV-7272-2022; Wang,
   Liang-Jen/AAR-1089-2020; Chen, Po/AAA-6492-2021; Tzeng,
   Nian-Sheng/AAU-4945-2021; Hong, Jau-Shyong/F-1920-2019
OI Hong, Jau-Shyong/0000-0002-3056-8401; Chang,
   Yun-Hsuan/0000-0001-8662-2457
FU Taiwan National Science Council [NSC98-2314-B-006-022-MY3,
   NSC100-2314-B-075B-010-MY3]; Taiwan Department of Health [DOH
   95-TD-M-113-055]; Taiwan National Health Research Institute
   [NHRI-EX-97-9738NI]; National Cheng Kung University Project for
   Promoting Academic Excellence and Developing World Class Research
   Centers
FX This work was supported in part by grant NSC98-2314-B-006-022-MY3 (to
   RBL) and NSC100-2314-B-075B-010-MY3 (to SYL) from the Taiwan National
   Science Council, grant DOH 95-TD-M-113-055 (to RBL) from the Taiwan
   Department of Health, grant NHRI-EX-97-9738NI (to RBL) from the Taiwan
   National Health Research Institute, and the National Cheng Kung
   University Project for Promoting Academic Excellence and Developing
   World Class Research Centers.
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NR 67
TC 13
Z9 13
U1 0
U2 11
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0001-690X
EI 1600-0447
J9 ACTA PSYCHIAT SCAND
JI Acta Psychiatr. Scand.
PD FEB
PY 2015
VL 131
IS 2
BP 120
EP 128
DI 10.1111/acps.12324
PG 9
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA AY1SS
UT WOS:000347372900005
PM 25131388
OA Bronze
DA 2025-06-11
ER

PT J
AU Trovato, E
   Rubegni, P
   Prignano, F
AF Trovato, Emanuele
   Rubegni, Pietro
   Prignano, Francesca
TI Place in therapy of anti-IL-17 and 23 in psoriasis according to the
   severity of comorbidities: a focus on cardiovascular disease and
   metabolic syndrome
SO EXPERT OPINION ON BIOLOGICAL THERAPY
LA English
DT Article
DE Psoriasis; biologics; cardiovascular disease; obesity; atherosclerosis
ID VASCULAR INFLAMMATION; ATHEROSCLEROSIS; INTERLEUKIN-17A; MODERATE;
   OUTCOMES; RISK
AB Introduction Psoriasis is an inflammatory disease nowadays considered not only as a cutaneous but as a systemic disease. Among the numerous comorbidities, psoriatic arthritis (PsA), depression, obesity, and cardiovascular disease (CVD) are considered the most frequent. In addition, metabolic syndrome (MetS), which involves hypertension, dyslipidemia, obesity, and atherosclerosis, has presented a higher prevalence in recent years, especially in psoriatic patients. Areas covered The mechanism linking anti-tumor necrosis factor (TNF) to MetS and CVD has been widely explained, while there are unknowns about inhibitors of interleukin (IL)-17 and -23. Considering the growing incidence of CVD in the world's population and in particular the strict correlation in patients with psoriasis, it is important to identify therapeutic options able to avoid a negative impact on patients with both conditions. The aim of this paper is to perform a review of the scientific literature with a focus on the pathogenetic mechanism linking psoriasis to CVD and MetS. Expert opinion The scientific evidence currently available allows us to consider and support the use of anti-IL-17 and anti-IL-23 as a first-line therapy choice in psoriatic patients with high risk of CVDs or MetS.
C1 [Trovato, Emanuele; Rubegni, Pietro] Univ Siena, Dept Med Surg & Neurol Sci, Unit Dermatol, Siena, Italy.
   [Prignano, Francesca] Univ Florence, Dept Hlth Sci, Dermatol Sect, Florence, Italy.
C3 University of Siena; University of Florence
RP Trovato, E (corresponding author), Univ Siena, Dept Med Surg & Neurol Sci, Unit Dermatol, Siena, Italy.
EM trovato.ema@gmail.com
OI Trovato, Emanuele/0000-0001-8301-9206
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NR 50
TC 20
Z9 20
U1 0
U2 4
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1471-2598
EI 1744-7682
J9 EXPERT OPIN BIOL TH
JI Expert Opin. Biol. Ther.
PD DEC 2
PY 2022
VL 22
IS 12
SI SI
BP 1443
EP 1448
DI 10.1080/14712598.2022.2093106
EA JUN 2022
PG 6
WC Biotechnology & Applied Microbiology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Research & Experimental Medicine
GA 7C5SA
UT WOS:000817237100001
PM 35726639
DA 2025-06-11
ER

PT J
AU Chae, JS
   Kim, OY
   Paik, JK
   Kang, R
   Seo, WJ
   Jeong, TS
   Sweeney, G
   Lee, SH
   Lee, JH
AF Chae, Jey Sook
   Kim, Oh Yoen
   Paik, Jean Kyung
   Kang, Ryungwoo
   Seo, Woo Ju
   Jeong, Tae-Sook
   Sweeney, Gary
   Lee, Sang-Hyun
   Lee, Jong Ho
TI Association of Lp-PLA2 activity and LDL size with
   interleukin-6, an inflammatory cytokine and oxidized LDL, a marker of
   oxidative stress, in women with metabolic syndrome
SO ATHEROSCLEROSIS
LA English
DT Article
DE Lp-PLA(2) activity; Interleukin-6; Oxidized LDL; LDL size; Metabolic
   syndrome; Women
ID ACTIVATING-FACTOR-ACETYLHYDROLASE; PHOSPHOLIPASE A(2) ACTIVITY;
   LOW-DENSITY-LIPOPROTEIN; CORONARY-HEART-DISEASE; RISK; ATHEROSCLEROSIS;
   EPIDEMIOLOGY
AB Objective: We investigated an association between lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) activity, inflammation, and oxidative stress in women with metabolic syndrome (MS).
   Methods: We performed a case-control study in MS women (n = 368) and non-MS women (n = 854). Lp-PLA(2) activity LDL particle size; leukocyte number; ox-LDL, LDL-cholesterol, TNF-alpha, IL-6, and CRP levels were measured.
   Results: MS women had smaller LDL particle size; higher plasma ox-LDL levels and Lp-PLA(2) activity; and higher serum TNF-alpha, IL-6, and CRP, than non-MS women. In controls, Lp-PLA(2) activity weakly but significantly correlated with LDL-cholesterol; in MS women, Lp-PLA(2) activity positively correlated with LDL-cholesterol, ox-LDL, TNF-alpha, and IL-6 after adjusting for age and BMI. The relationship between Lp-PLA(2) activity and ox-LDL still maintained after further adjustment for LDL-cholesterol. Additionally, Lp-PLA(2) activity together with LDL particle size were significant independent predictors of MS (multivariate analysis), and ox-LDL was a major contributor to the increase in Lp-PLA(2) activity in MS women (multiple stepwise regression). In a subgroup analysis, Lp-PLA(2) activity was negatively associated with IL-6 levels in non-MS postmenopausal women, but positively with IL-6 in both postmenopausal and premenopausal women with MS. Postmenopausal women with MS had significantly higher Lp-PLA(2) activity, ox-LDL and IL-6 than those without MS, and premenopausal women with or without MS, after the adjustment.
   Conclusions: Elevated plasma Lp-PLA(2) activity was associated with an increase in inflammatory cytokines, particularly IL-6 and ox-LDL in MS women. This association was also affected by menopause status, suggesting that Lp-PLA(2) may represent a novel marker for oxidation and inflammation in MS. Crown Copyright (C) 2011 Published by Elsevier Ireland Ltd. All rights reserved.
C1 [Lee, Jong Ho] Yonsei Univ, Dept Food & Nutr, Coll Human Ecol, Natl Res Lab Clin Nutrigenet Nutrigen, Seoul 120749, South Korea.
   [Chae, Jey Sook; Kim, Oh Yoen; Paik, Jean Kyung; Kang, Ryungwoo; Seo, Woo Ju; Lee, Jong Ho] Yonsei Univ, Res Inst Sci Aging, Seoul 120749, South Korea.
   [Kang, Ryungwoo; Lee, Jong Ho] Yonsei Univ, Coll Human, Brain Korea 21 Project, Dept Food & Nutr, Seoul 120749, South Korea.
   [Jeong, Tae-Sook] Korea Res Inst Biosci & Biotechnol, Natl Res Lab Lipid Metab & Atherosclerosis, Taejon, South Korea.
   [Sweeney, Gary] Inst Pasteur Korea, Seoul, South Korea.
   [Sweeney, Gary] York Univ, Dept Biol, Toronto, ON M3J 2R7, Canada.
   [Lee, Sang-Hyun] Natl Hlth Insurance Corp Ilsan Hosp, Dept Family Practice, Goyang Si, South Korea.
C3 Yonsei University; Yonsei University; Yonsei University; Korea Research
   Institute of Bioscience & Biotechnology (KRIBB); Institut Pasteur Korea;
   York University - Canada
RP Lee, JH (corresponding author), Yonsei Univ, Dept Food & Nutr, Coll Human Ecol, Natl Res Lab Clin Nutrigenet Nutrigen, 134 Shinchon Ding, Seoul 120749, South Korea.
EM jhleeb@yonsei.ac.kr
RI Kim, Oh/AAA-6492-2022; Lee, Sang-Hyun/ABR-3363-2022
FU National Research Foundation, Ministry of Education, Science and
   Technology Republic of Korea [2010-0015017, 2010-0000317]
FX This work was supported by the National Research Foundation, Ministry of
   Education, Science and Technology (Mid-career Researcher Program:
   2010-0015017, and 2010-0000317) Republic of Korea.
CR Ahonen T, 2009, MEDIAT INFLAMM, V2009, DOI 10.1155/2009/959281
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NR 29
TC 25
Z9 25
U1 0
U2 9
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0021-9150
EI 1879-1484
J9 ATHEROSCLEROSIS
JI Atherosclerosis
PD OCT
PY 2011
VL 218
IS 2
BP 499
EP 506
DI 10.1016/j.atherosclerosis.2011.06.036
PG 8
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 836WJ
UT WOS:000296147600073
PM 21762913
DA 2025-06-11
ER

PT J
AU Wittbrodt, MT
   Moazzami, K
   Shah, AJ
   Lima, BB
   Hammadah, M
   Mehta, PK
   Quyyumi, AA
   Vaccarino, V
   Nye, JA
   Bremner, JD
AF Wittbrodt, Matthew T.
   Moazzami, Kasra
   Shah, Amit J.
   Lima, Bruno B.
   Hammadah, Muhammad
   Mehta, Puja K.
   Quyyumi, Arshed A.
   Vaccarino, Viola
   Nye, Jonathon A.
   Bremner, J. Douglas
TI Neural responses during acute mental stress are associated with angina
   pectoris
SO JOURNAL OF PSYCHOSOMATIC RESEARCH
LA English
DT Article
DE Angina; Coronary artery disease; Mental stress; Frontal lobe;
   Cardiovascular
ID INDUCED MYOCARDIAL-ISCHEMIA; CHEST-PAIN; PSYCHOMETRIC PROPERTIES; HEALTH
   BEHAVIORS; SYNDROME-X; HEART; DISORDER; BRAIN; METAANALYSIS; STIMULATION
AB Angina pectoris is associated with increased risk of adverse cardiovascular events in coronary artery disease (CAD) patients, an effect not entirely attributable to the severity of CAD.
   Objective: Examine brain correlates of mental stress in patients with CAD with and without a history of angina.
   Methods: Participants (n = 170) with stable CAD completed the Seattle Angina Questionnaire along with other psychometric assessments. In this cross-sectional study, participants underwent laboratory-based mental stress testing using mental arithmetic and public speaking tasks along with control conditions in conjunction with positron emission tomography brain imaging using radiolabeled water. Brain activity during mental stress was compared between participants who did or did not report chest pain/angina in the previous month. A factor analysis was coupled with dominance analysis to identify brain regions associated with angina.
   Results: Participants reporting angina in the past month experienced greater (p<.005) activations within the left: frontal lobe (z = 4.01), temporal gyrus (z = 3.32), parahippocampal gyrus (z = 3.16), precentral gyrus (z = 3.14), right fusiform gyrus (z = 3.07), and bilateral cerebellum (z = 3.50) and deactivations within the right frontal gyrus (z = 3.67), left precuneus (z = 3.19), and left superior temporal gyrus (z = 3.11) during mental stress. A factor containing the left motor areas, inferior frontal lobe, and operculum (average McFadden's number addition = 0.057) in addition to depression severity (0.10) and adulthood trauma exposure (0.064) correlated with angina history.
   Conclusions: Self-reported angina in patients with stable CAD is associated with increased neural responses to stress in a network including the inferior frontal lobe, motor areas, and operculum, potentially indicating an upregulated pain perception response.
C1 [Wittbrodt, Matthew T.; Bremner, J. Douglas] Emory Univ, Sch Med, Dept Psychiat & Behav Sci, Atlanta, GA USA.
   [Moazzami, Kasra; Shah, Amit J.; Lima, Bruno B.; Hammadah, Muhammad; Vaccarino, Viola] Emory Univ, Rollins Sch Publ Hlth, Dept Epidemiol, Atlanta, GA 30322 USA.
   [Moazzami, Kasra; Shah, Amit J.; Lima, Bruno B.; Hammadah, Muhammad; Mehta, Puja K.; Quyyumi, Arshed A.; Vaccarino, Viola] Emory Univ, Sch Med, Dept Med, Div Cardiol, Atlanta, GA USA.
   [Nye, Jonathon A.; Bremner, J. Douglas] Emory Univ, Sch Med, Dept Radiol, Atlanta, GA 30322 USA.
   [Shah, Amit J.; Bremner, J. Douglas] Atlanta VA Med Ctr, Decatur, GA USA.
C3 Emory University; Emory University; Rollins School Public Health; Emory
   University; Emory University; US Department of Veterans Affairs;
   Veterans Health Administration (VHA); Atlanta VA Health Care System;
   Atlanta VA Medical Center
RP Wittbrodt, MT (corresponding author), 1821 Clifton Rd,Room 214, Atlanta, GA 30307 USA.
EM mattwittbrodt@emory.edu
RI Lima, Bruno/AAB-2807-2021; Vaccarino, Viola/AAW-5600-2020; Wittbrodt,
   Matt/AAW-3858-2020; Bremner, James/B-1632-2013
OI Vaccarino, Laura Viola/0000-0002-9054-0654; Wittbrodt,
   Matthew/0000-0002-9533-8041
FU National Institute of Health [P01 HL101398, HL088726, MH076955,
   MH067547-01, MH56120, RR016917, HL077506, HL068630, HL109413, HL125246,
   HL127251, K23 HL127251]
FX This study was supported by National Institute of Health (P01 HL101398,
   HL088726, MH076955, MH067547-01, MH56120, RR016917, HL077506, HL068630,
   HL109413, HL125246, HL127251, and K23 HL127251. Funding sources had no
   involvement in study design, data collection, data analysis,
   interpretation of data, writing of the report, or decision to submit the
   article.
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NR 85
TC 9
Z9 9
U1 0
U2 2
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-3999
EI 1879-1360
J9 J PSYCHOSOM RES
JI J. Psychosomat. Res.
PD JUL
PY 2020
VL 134
AR 110110
DI 10.1016/j.jpsychores.2020.110110
PG 10
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA LU3NS
UT WOS:000537666700002
PM 32345456
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Obulhasim, G
   Yasen, M
   Kajino, K
   Mogushi, K
   Tanaka, S
   Mizushima, H
   Tanaka, H
   Arii, S
   Hino, O
AF Obulhasim, Gulanbar
   Yasen, Mahmut
   Kajino, Kazunori
   Mogushi, Kaoru
   Tanaka, Shinji
   Mizushima, Hiroshi
   Tanaka, Hiroshi
   Arii, Shigeki
   Hino, Okio
TI Up-regulation of dbpA mRNA in hepatocellular carcinoma associated with
   metabolic syndrome
SO HEPATOLOGY INTERNATIONAL
LA English
DT Article
DE Hepatocellular carcinoma; Metabolic syndrome; dbpA expression; Oxidative
   stress
ID BOX-BINDING PROTEIN; NONALCOHOLIC STEATOHEPATITIS; METHYLATION STATUS;
   NATURAL-HISTORY; LIVER-DISEASE; HEPATITIS; CIRRHOSIS; RISK; OBESITY;
   INCREASES
AB Metabolic syndrome (MS) is a group of recognized risk factors for the development of hepatocellular carcinoma (HCC) in patients with chronic liver disease. The aim of this study was to analyze the clinicopathological characteristics of HCC patients with MS and the risk factors for recurrence. Also, the aim was to investigate the cold shock protein: DNA-binding protein A (dbpA) expression in HCC patients with MS.
   A total of 243 patients who underwent curative resections for HCC were classified into two groups. dbpA expression was investigated in 66 HCC patients with MS and in 30 patients without MS by using real-time RT-PCR. Promoter methylation status was examined by using MS-PCR.
   The incidence of metabolic factors affect the HCC significantly higher in non-B non-C patients than in hepatitis B virus (HBV) or hepatitis C virus (HCV) patients (P < 0.001). Univariate analysis of HCC patients with MS recurrence revealed aspartate amino transferase (AST), multiple tumors, liver damage, hepatic vein invasion, advanced cancer stages (P < 0.01), alpha-fetoprotein (AFP) and diabetes mellitus type II (P < 0.05) as risk factors. Multivariate analysis, AST, multiple tumors, and hepatic vein invasion (P < 0.01) were identified as independent factors for the recurrence. dbpA mRNA was higher in patients with MS than in those without MS (P = 0.016), and it was mostly upregulated in non-B non-C HCC patients with MS than in non-B non-C HCC patients without HBV or HCV. Especially, in HCC patients with diabetes mellitus type II, the mRNA and protein levels were highly upregulated. The dbpA expression was regulated by promoter methylation status (P < 0.05).
   This study identifies that dbpA may accelerate the hepatocarcinogenesis in HCC patients with MS via inflammation-induced and oxidative stress pathways. The demethylation-related epigenetic activation may be one of the regulating factors for HCC patients with MS.
C1 [Obulhasim, Gulanbar; Kajino, Kazunori; Hino, Okio] Juntendo Univ, Sch Med, Dept Pathol & Oncol, Bunkyo Ku, Tokyo 1138421, Japan.
   [Obulhasim, Gulanbar; Yasen, Mahmut] Xinjiang Med Univ, Xinjiang Uyghur Tumor Hosp, Dept Surg, Urumqi 830011, Xinjiang, Peoples R China.
   [Yasen, Mahmut; Tanaka, Shinji; Arii, Shigeki] Tokyo Med & Dent Univ, Dept Hepatobiliary Pancreat Surg, Bunkyo Ku, Tokyo 1138510, Japan.
   [Mogushi, Kaoru; Mizushima, Hiroshi; Tanaka, Hiroshi] Tokyo Med & Dent Univ, Dept Computat Biol & Bioinformat, Bunkyo Ku, Tokyo 1138510, Japan.
C3 Juntendo University; Xinjiang Medical University; Institute of Science
   Tokyo; Tokyo Medical & Dental University (TMDU); Institute of Science
   Tokyo; Tokyo Medical & Dental University (TMDU)
RP Yasen, M (corresponding author), Tokyo Med & Dent Univ, Dept Hepatobiliary Pancreat Surg, Bunkyo Ku, 1-5-45 Yushima, Tokyo 1138510, Japan.
EM mahmut@bioinfo.tmd.ac.jp
OI Mogushi, Kaoru/0000-0002-2618-8684
FU Special Coordination Funds for Promoting Science and Technology (Japan
   Science and Technology Agency); Ministry of Education, Culture, Sports,
   Science and Technology of Japan
FX This work was supported by Special Coordination Funds for Promoting
   Science and Technology (Japan Science and Technology Agency), and a
   Grant-in-Aid from Ministry of Education, Culture, Sports, Science and
   Technology of Japan.
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NR 31
TC 3
Z9 3
U1 0
U2 8
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1936-0533
EI 1936-0541
J9 HEPATOL INT
JI Hepatol. Int.
PD MAR
PY 2013
VL 7
IS 1
BP 215
EP 225
DI 10.1007/s12072-012-9357-4
PG 11
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 109FC
UT WOS:000316350600026
PM 26201636
DA 2025-06-11
ER

PT J
AU Saxbe, D
   Corner, GW
   Khaled, M
   Horton, K
   Wu, B
   Khoddam, HL
AF Saxbe, Darby
   Corner, Geoffrey W.
   Khaled, Mona
   Horton, Katelyn
   Wu, Brian
   Khoddam, Hannah Lyden
TI The weight of fatherhood: identifying mechanisms to explain paternal
   perinatal weight gain
SO HEALTH PSYCHOLOGY REVIEW
LA English
DT Article
DE Fathers; weight; obesity; adiposity; paternal; testosterone; HPA axis;
   sleep; physical activity; exercise; mood disorders; couples
ID SHORT-SLEEP DURATION; BODY-MASS INDEX; STRESSFUL LIFE EVENTS; 12 MONTHS
   POSTPARTUM; PHYSICAL-ACTIVITY; UNITED-STATES; SERUM TESTOSTERONE;
   METABOLIC SYNDROME; CHILDHOOD OBESITY; INDIVIDUAL VARIATION
AB Men appear to gain weight during the transition to parenthood, and fathers are heavier than non-fathers. Paternal perinatal weight gain may set weight trajectories in midlife and have long-term health implications. Since men do not undergo the physical demands of pregnancy and breastfeeding, the specific mechanisms underlying weight gain in new fathers warrant investigation. This review aims to stimulate research on paternal perinatal weight gain by suggesting testable potential mechanisms that (1) show change across the transition to parenthood and (2) play a role in weight and body composition. We identify seven mechanisms, within three categories: behavioural mechanisms (sleep, physical activity, and diet), hormonal mechanisms (testosterone and cortisol), and psychological mechanisms (depression and stress). We also discuss direct effects of partner pregnancy influences (e.g., couvade syndrome') on men's body weight. In presenting each mechanism, we discuss how it may be affected by the transition to parenthood, and then review its role in body composition and weight. Next, we describe bidirectional and interactive effects, discuss timing, and present three broad research questions to propel theoretical development.
C1 [Saxbe, Darby; Corner, Geoffrey W.; Khaled, Mona; Horton, Katelyn; Khoddam, Hannah Lyden] Univ Southern Calif, Dept Psychol, Los Angeles, CA 90007 USA.
   [Wu, Brian] Univ Southern Calif, Keck Sch Med, Los Angeles, CA USA.
C3 University of Southern California; University of Southern California
RP Saxbe, D (corresponding author), Univ Southern Calif, Dept Psychol, Los Angeles, CA 90007 USA.
EM dsaxbe@usc.edu
FU National Science Foundation CAREER Award [1552452]; National Science
   Foundation Graduate Research Fellowship; Division Of Behavioral and
   Cognitive Sci; Direct For Social, Behav & Economic Scie [1552452]
   Funding Source: National Science Foundation
FX This work was funded by the National Science Foundation CAREER Award to
   D. S. [grant number 1552452], and a National Science Foundation Graduate
   Research Fellowship to G. W. C.
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NR 115
TC 26
Z9 26
U1 0
U2 27
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 1743-7199
EI 1743-7202
J9 HEALTH PSYCHOL REV
JI Health Psychol. Rev.
PY 2018
VL 12
IS 3
BP 294
EP 311
DI 10.1080/17437199.2018.1463166
PG 18
WC Psychology, Clinical
WE Social Science Citation Index (SSCI)
SC Psychology
GA GP7DK
UT WOS:000441052500005
PM 29712505
DA 2025-06-11
ER

PT J
AU Kolb, H
   Martin, S
AF Kolb, Hubert
   Martin, Stephan
TI Environmental/lifestyle factors in the pathogenesis and prevention of
   type 2 diabetes
SO BMC MEDICINE
LA English
DT Review
DE Type 2 diabetes; Environment; Lifestyle; Diabetes risk factors; Diabetes
   prevention; Diet; Physical activity; beta-cells
ID BETA-CELL FUNCTION; Y GASTRIC BYPASS; DOSE-RESPONSE METAANALYSIS; FATTY
   LIVER-DISEASE; C-REACTIVE PROTEIN; ALL-CAUSE MORTALITY; LONG-TERM
   EXPOSURE; LOW-CALORIE DIET; INSULIN SENSITIVITY; METABOLIC SYNDROME
AB Background: Environmental and lifestyle changes, in addition to the ageing of populations, are generally believed to account for the rapid global increase in type 2 diabetes prevalence and incidence in recent decades.
   Discussion: In this review, we present a comprehensive overview of factors contributing to diabetes risk, including aspects of diet quality and quantity, little physical activity, increased monitor viewing time or sitting in general, exposure to noise or fine dust, short or disturbed sleep, smoking, stress and depression, and a low socioeconomic status. In general, these factors promote an increase in body mass index. Since loss of beta-cell function is the ultimate cause of developing overt type 2 diabetes, environmental and lifestyle changes must have resulted in a higher risk of beta-cell damage in those at genetic risk. Multiple mechanistic pathways may come into play.
   Conclusions: Strategies of diabetes prevention should aim at promoting a 'diabetes-protective lifestyle' whilst simultaneously enhancing the resistance of the human organism to pro-diabetic environmental and lifestyle factors. More research on diabetes-protective mechanisms seems warranted.
C1 [Kolb, Hubert; Martin, Stephan] Univ Duesseldorf, Fac Med, Dusseldorf, Germany.
   [Kolb, Hubert; Martin, Stephan] Duesseldorf Catholic Hosp Grp, West German Ctr Diabet & Hlth, Hohensandweg 37, D-40591 Dusseldorf, Germany.
RP Kolb, H (corresponding author), Univ Duesseldorf, Fac Med, Dusseldorf, Germany.; Kolb, H (corresponding author), Duesseldorf Catholic Hosp Grp, West German Ctr Diabet & Hlth, Hohensandweg 37, D-40591 Dusseldorf, Germany.
EM hubert.kolb@uni-duesseldorf.de
FU Gesellschaft von Freunden und Forderern der Heinrich-Heine-Universitat
   Dusseldorf e.V.
FX This work was supported by the Gesellschaft von Freunden und Forderern
   der Heinrich-Heine-Universitat Dusseldorf e.V.
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NR 193
TC 462
Z9 520
U1 9
U2 183
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1741-7015
J9 BMC MED
JI BMC Med.
PD JUL 19
PY 2017
VL 15
AR 131
DI 10.1186/s12916-017-0901-x
PG 11
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA FA8LC
UT WOS:000405696500001
PM 28720102
OA Green Published, gold
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Buckingham, JC
AF Buckingham, JC
TI Glucocorticoids: exemplars of multi-tasking
SO BRITISH JOURNAL OF PHARMACOLOGY
LA English
DT Article
DE glucocorticoids; HPA axis; glucocorticoid receptors
ID RECEPTOR; CORTICOSTERONE; PITUITARY; CORTISOL; STRESS; CORTICOTROPIN;
   ANNEXIN-1; RESPONSES; HORMONE; MICE
AB Well over 80 years ago Philip Smith described the beneficial clinical effects of adrenocortical extracts in animal models of adrenal insufficiency. In the ensuing years, scientists across the globe have sought to understand the mechanisms by which adrenal hormones and their synthetic analogues produce their complex and varied actions. Particular attention has focused on the glucocorticoids, partly because they have a vital place in the treatment of inflammatory and autoimmune disorders but also because dysregulation of the secretion and/or activity of endogenous glucocorticoids is increasingly implicated in a number of common disorders that pose a growing clinical burden, such as obesity, type II diabetes, the metabolic syndrome, hypertension and depression. This review considers some of the key advances that have been made in Our understanding of the physiology, pathology and pharmacology of the glucocorticoids. Emphasis is placed on the molecular mechanisms of glucocorticoid signalling and the complex mechanisins that regulate the access of steroids in the systemic circulation to their receptors in their various target cells and tissues. In addition, consideration is given to the irreversible 4 organisational' actions of glucocorticoids in perinatal life and to the potential role of the steroids in the aetiology of disease.
C1 Univ London Imperial Coll Sci Technol & Med, Div Neurosci & Mental Hlth, Dept Cellular & Mol Neurosci, London W12 0NN, England.
C3 Imperial College London
RP Univ London Imperial Coll Sci Technol & Med, Div Neurosci & Mental Hlth, Dept Cellular & Mol Neurosci, London W12 0NN, England.
EM j.buckingham@imperial.ac.uk
FU Biotechnology and Biological Sciences Research Council [BB/E52708X/1]
   Funding Source: Medline
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NR 37
TC 196
Z9 251
U1 0
U2 11
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0007-1188
EI 1476-5381
J9 BRIT J PHARMACOL
JI Br. J. Pharmacol.
PD JAN
PY 2006
VL 147
SU 1
BP S258
EP S268
DI 10.1038/sj.bjp.0706456
PG 11
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 009BZ
UT WOS:000235087400030
PM 16402112
OA Green Published
DA 2025-06-11
ER

PT J
AU Ahmadnezhad, M
   Arefhosseini, SR
   Parizadeh, MR
   Tavallaie, S
   Tayefi, M
   Darroudi, S
   Ghazizadeh, H
   Moohebati, M
   Ebrahimi, M
   Heidari-Bakavoli, A
   Azarpajouh, MR
   Ferns, GA
   Mogharebzadeh, V
   Ghayour-Mobarhan, M
AF Ahmadnezhad, Mahsa
   Arefhosseini, Seyed Rafie
   Parizadeh, Mohammad Reza
   Tavallaie, Shima
   Tayefi, Maryam
   Darroudi, Susan
   Ghazizadeh, Hamideh
   Moohebati, Mohsen
   Ebrahimi, Mahmoud
   Heidari-Bakavoli, Alireza
   Azarpajouh, Mahmoud Reza
   Ferns, Gordon A.
   Mogharebzadeh, Vahid
   Ghayour-Mobarhan, Majid
TI Association between serum uric acid, high sensitive C-reactive protein
   and pro-oxidant-antioxidant balance in patients with metabolic syndrome
SO BIOFACTORS
LA English
DT Article
DE pro-oxidant; antioxidant; PAB; metabolic syndrome; hs-CRP; uric acid
ID OXIDATIVE STRESS MARKERS; RISK-FACTORS; INSULIN-RESISTANCE; IKK-BETA;
   VITAMIN; DISEASE; INFLAMMATION; POPULATION; OBESITY; IMPACT
AB There is persuasive evidence that oxidative stress and inflammation are features of the metabolic syndrome (MetS). We have investigated the relationship between serum pro-oxidant-antioxidant balance (PAB), serum uric acid, and high sensitive C-reactive protein (hs-CRP) in 7,208 participants from the MASHAD study cohort, who were categorized as having MetS, or not, using International Diabetes Foundation (IDF) criteria. Serum hs-CRP was measured by Polyethylene glycol (PEG)-enhanced immunoturbidimetry method using an Alycon analyzer (ABBOTT, Chicago, IL, USA). A colorimetric method was used to determine serum PAB. Serum PAB values were significantly higher in the individuals with MetS compared to those without (P<0.001). Furthermore, there was a step-wise increase in mean serum PAB concentrations as the number of components of the MetS increased. The combination of features of MetS had different association with serum PAB and hs-CRP. Multiple linear regression analysis showed that body mass index (BMI, B=2.04, P<0.001), physical activity level (PAL, B=18.728, P=0.001), serum uric acid (B=-1.545, P=0.003), and serum C-reactive protein (B=0.663, P<0.001) were associated with serum PAB in individuals with MetS. Multiple logistic regression analysis showed that serum PAB (B=0.002, P<0.001, CI=1.001-1.003), serum C-reactive protein (B=0.007, P< 0.015, CI=1.001-1.013), and serum uric acid (B=0.207, P<0.001, CI=1.186-1.277) were all significantly associated with MetS. Serum PAB was strongly associated with serum uric acid and serum hs-CRP. Moreover, serum PAB as well as serum uric acid and serum hs-CRP were independently associated with MetS. Individual features of MetS were also associated with serum hs-CRP and PAB. (c) 2018 BioFactors, 44(3):263-271, 2018
C1 [Ahmadnezhad, Mahsa] Tabriz Univ Med Sci, Dept Community Nutr, Nutr Res Ctr, Tabriz, Iran.
   [Ahmadnezhad, Mahsa] Mashhad Univ Med Sci, Student Res Comm, Fac Med, Mashhad, Iran.
   [Arefhosseini, Seyed Rafie] Tabriz Univ Med Sci, Dept Nutr Biochem, Tabriz, Iran.
   [Parizadeh, Mohammad Reza; Tavallaie, Shima; Tayefi, Maryam; Darroudi, Susan; Ghayour-Mobarhan, Majid] Mashhad Univ Med Sci, Metab Syndrome Res Ctr, Fac Med, Mashhad, Iran.
   [Ghazizadeh, Hamideh] Mashhad Univ Med Sci, Sch Med, Dept Modern Sci & Technol, Mol Med Grp, Mashhad, Iran.
   [Moohebati, Mohsen; Ebrahimi, Mahmoud; Heidari-Bakavoli, Alireza; Azarpajouh, Mahmoud Reza] Mashhad Univ Med Sci, Cardiovasc Res Ctr, Fac Med, Mashhad, Iran.
   [Ferns, Gordon A.] Brighton & Sussex Med Sch, Div Med Educ, Brighton BN1 9PH, Sussex, England.
   [Mogharebzadeh, Vahid] Mazandaran Univ Med Sci, Fac Hlth, Dept Biostat, Sari, Iran.
C3 Tabriz University of Medical Science; Mashhad University of Medical
   Sciences; Tabriz University of Medical Science; Mashhad University of
   Medical Sciences; Mashhad University of Medical Sciences; Mashhad
   University of Medical Sciences; University of Brighton; University of
   Sussex; Mazandaran University of Medical Sciences
RP Ghayour-Mobarhan, M (corresponding author), Mashhad Univ Med Sci, Metab Syndrome Res Ctr, Fac Med, Mashhad, Iran.; Arefhosseini, SR (corresponding author), Sch Nutr & Food Sci, Nutr Biochem, Tabriz, Iran.
EM arefhosseini@gmail.com; ghayourm@mums.ac.ir
RI Ghayour-Mobarhan, Majid/AAY-5963-2020; Ghazizadeh,
   Hamideh/ABE-8941-2020; Ebrahimi, Mehrzad/AAO-9791-2021; mohebati,
   mohsen/AAR-2016-2021
OI tayefi, maryam/0000-0003-4637-7754
FU Tabriz University of Medical Science; Mashhad University of Medical
   Sciences
FX This study was support by grant from Tabriz University of Medical
   Science and Mashhad University of Medical Sciences.
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NR 35
TC 26
Z9 27
U1 1
U2 10
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0951-6433
EI 1872-8081
J9 BIOFACTORS
JI Biofactors
PD MAY-JUN
PY 2018
VL 44
IS 3
BP 263
EP 271
DI 10.1002/biof.1424
PG 9
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA GK0BO
UT WOS:000435770800007
PM 29638023
DA 2025-06-11
ER

PT J
AU Khlifi, R
   Dhaouefi, Z
   Ben Toumia, I
   Lahmar, A
   Sioud, F
   Bouhajeb, R
   Bellalah, A
   Chekir-Ghedira, L
AF Khlifi, Rihab
   Dhaouefi, Zaineb
   Ben Toumia, Imene
   Lahmar, Aida
   Sioud, Fairouz
   Bouhajeb, Rim
   Bellalah, Ahlem
   Chekir-Ghedira, Leila
TI Erica multiflora extract rich in quercetin-3-O-glucoside and
   kaempferol-3-O-glucoside alleviates high fat and fructose diet-induced
   fatty liver disease by modulating metabolic and inflammatory pathways in
   Wistar rats
SO JOURNAL OF NUTRITIONAL BIOCHEMISTRY
LA English
DT Article
DE Erica multiflora; LC-MS/MS; High-fat-fructose diet; Metabolic syndrome;
   Oxidative stress; Inflammation
ID OXIDATIVE STRESS; INSULIN-RESISTANCE; ANTIOXIDANT ACTIVITY;
   NITRIC-OXIDE; IN-VITRO; QUERCETIN; ACID; HYPERLIPIDEMIA; FLAVONOIDS;
   STEATOSIS
AB The wide morbidity of obesity has heightened interest in providing natural and safe compounds to maintain optimal health. The present study was designed to determine the chemical constituents and the effects of methanol leaf extract from Erica multiflora (M-EML) on mitigating high-fat and high-fructose diet (HFFD)-induced metabolic syndrome (MS).
   LC-MS/MS characterization of M-EML allowed the identification of 14 secondary metabolites and showed that quercetin-3-O-glucoside and kaempferol-3-O-glucoside were the main compounds of our extract. In the in vivo study, the oral administration of M-EML (250 mg/kg) during the last 4 weeks of the experimentation alleviated HFFD-induced obesity, insulin resistance (IR) and cardiovascular diseases. Thus, M-EML treatment significantly normalized body and liver weight, allowed to a sharp decline in plasma levels of TC, TG and LDL-c by 32%, 35% and 66%, respectively. Moreover, hepatic enzymes, total and direct bilirubin, lipase and uric acid levels have been diminished in treated group. Histopathology of the liver confirmed the changes induced by HFFD and the hepatoprotective effect of M-EML. The supply of M-EML reduced NO production and cellular lysosomal enzyme activity by 44% and 60%, respectively compared to HFFD. Besides, M-EML showed decreased pro-inflammatory cytokines levels (259.5 +/- 47.35 pg/ml and 56.08 +/- 1.56 pg/ml) of TNF-alpha and IL-6, respectively.
   In addition, M-EML reduced liver malondialdehyde (MDA) content and enhanced superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) activities. In contrast, these enzymatic activities have been disrupted in HFFD rats.
   Overall, M-EML prevented obesity through the modulation of metabolic syndrome, reducing inflammation and promoting antioxidant enzymes activities. (C) 2020 Elsevier Inc. All rights reserved.
C1 [Khlifi, Rihab; Dhaouefi, Zaineb; Ben Toumia, Imene; Lahmar, Aida; Sioud, Fairouz; Bouhajeb, Rim; Chekir-Ghedira, Leila] Univ Monastir, Fac Dent Med, Unity Bioact & Nat Subst & Biotechnol UR17ES49, Avicenna St, Monastir 5000, Tunisia.
   [Khlifi, Rihab] Higher Inst Biotechnol Monastir, Ave Tahar Hadded,BP 74, Monastir 5000, Tunisia.
   [Ben Toumia, Imene; Sioud, Fairouz; Bouhajeb, Rim] Univ Monastir, Fac Pharm, Avicenna St, Monastir 5000, Tunisia.
   [Bellalah, Ahlem] Fattouma Bourguiba Univ Hosp, Dept Pathol, Monastir, Tunisia.
C3 Universite de Monastir; Universite de Monastir; Universite de Monastir;
   Universite de Monastir; Hopital Fattouma Bourguiba
RP Khlifi, R (corresponding author), Univ Monastir, Fac Dent Med, Unity Bioact & Nat Subst & Biotechnol UR17ES49, Avicenna St, Monastir 5000, Tunisia.
EM rihabkhlifi@gmail.com
OI dhaouefi, zaineb/0000-0002-2004-0953
FU Ministry of Higher Education, Scientific Research and Technology,
   Tunisia
FX We acknowledge the "Ministry of Higher Education, Scientific Research
   and Technology, Tunisia", for the support of this study.
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NR 87
TC 36
Z9 38
U1 2
U2 29
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0955-2863
EI 1873-4847
J9 J NUTR BIOCHEM
JI J. Nutr. Biochem.
PD DEC
PY 2020
VL 86
AR 108490
DI 10.1016/j.jnutbio.2020.108490
PG 11
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA OP2IL
UT WOS:000587904600006
PM 32920086
DA 2025-06-11
ER

PT J
AU Walrabenstein, W
   Wagenaar, CA
   van de Put, M
   van der Leeden, M
   Gerritsen, M
   Twisk, JWR
   van der Esch, M
   van Middendorp, H
   Weijs, PJM
   Roorda, LD
   van Schaardenburg, D
AF Walrabenstein, Wendy
   Wagenaar, Carlijn A.
   van de Put, Marieke
   van der Leeden, Marike
   Gerritsen, Martijn
   Twisk, Jos W. R.
   van der Esch, Martin
   van Middendorp, Henriet
   Weijs, Peter J. M.
   Roorda, Leo D.
   van Schaardenburg, Dirkjan
TI A multidisciplinary lifestyle program for metabolic syndrome-associated
   osteoarthritis: the "Plants for Joints" randomized controlled trial
SO OSTEOARTHRITIS AND CARTILAGE
LA English
DT Article
DE Osteoarthritis"; Diet; Physical activity; Stress management; Metabolic
   syndrome
ID PATIENT-REPORTED OUTCOMES; FAT VEGAN DIET; KNEE OSTEOARTHRITIS; HIP
   OSTEOARTHRITIS; OBESE ADULTS; WEIGHT-LOSS; RISK; INFLAMMATION;
   OVERWEIGHT; MANAGEMENT
AB Objective: To determine the effectiveness of the "Plants for Joints" multidisciplinary lifestyle program in patients with metabolic syndrome-associated osteoarthritis (MSOA).Design: Patients with hip or knee MSOA were randomized to the intervention or control group. The intervention group followed a 16-week program in addition to usual care based on a whole food plant-based diet, physical activity, and stress management. The control group received usual care. The patient-reported Western Ontario and McMasters Universities Osteoarthritis Index (WOMAC) total score (range 0-96) was the primary outcome. Secondary outcomes included other patient-reported, anthropometric, and metabolic measures. An intention-to-treat analysis with a linear-mixed model adjusted for baseline values was used to analyze between-group differences.Results: Of the 66 people randomized, 64 completed the study. Participants (84% female) had a mean (SD) age of 63 (6) years and body mass index of 33 (5) kg/m2. After 16 weeks, the intervention group (n = 32) had a mean 11-point larger improvement in WOMAC-score (95% CI 6-16; p = 0.0001) compared to the control group. The intervention group also lost more weight (-5 kg), fat mass (-4 kg), and waist circumference (-6 cm) compared to the control group. Patient-Reported Outcomes Measurement Information System (PROMIS) fatigue, pain interference, C-reactive protein, hemoglobin A1c, fasting glucose, and low-density lipoproteins improved in the intervention versus the control group, while other PROMIS measures, blood pressure, high-density lipoproteins, and triglycerides did not differ significantly between the groups.Conclusion: The "Plants for Joints" lifestyle program reduced stiffness, relieved pain, and improved physical function in people with hip or knee MSOA compared to usual care.(c) 2023 The Authors. Published by Elsevier Ltd on behalf of Osteoarthritis Research Society International. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
C1 [Walrabenstein, Wendy; Wagenaar, Carlijn A.; van de Put, Marieke; van der Leeden, Marike; Gerritsen, Martijn; van der Esch, Martin; Roorda, Leo D.; van Schaardenburg, Dirkjan] Reade Ctr Rheumatol & Rehabil, Amsterdam, Netherlands.
   [Walrabenstein, Wendy; Wagenaar, Carlijn A.; van Schaardenburg, Dirkjan] Univ Amsterdam, Amsterdam UMC, Dept Clin Immunol & Rheumatol, Amsterdam, Netherlands.
   [Walrabenstein, Wendy; Wagenaar, Carlijn A.; Gerritsen, Martijn; van Schaardenburg, Dirkjan] Amsterdam Rheumatol & Immunol Ctr, Amsterdam, Netherlands.
   [Walrabenstein, Wendy] Amsterdam Univ Appl Sci, Ctr Expertise Urban Vital, Dept Nutr & Dietet, Amsterdam, Netherlands.
   [van der Leeden, Marike] Vrije Univ, Amsterdam UMC, Dept Rehabil Med, Amsterdam, Netherlands.
   [van der Leeden, Marike; Weijs, Peter J. M.] Amsterdam Movement Sci Res Inst, Amsterdam, Netherlands.
   [Twisk, Jos W. R.] Vrije Univ, Amsterdam UMC, Dept Epidemiol & Data Sci, Amsterdam, Netherlands.
   [van der Esch, Martin] Amsterdam Univ Appl Sci, Fac Hlth, Ctr Expertise Urban Vital, Amsterdam, Netherlands.
   [van Middendorp, Henriet] Leiden Univ, Inst Psychol, Hlth Med & Neuropsychol Unit, Leiden, Netherlands.
   [Weijs, Peter J. M.] Vrije Univ, Amsterdam UMC, Dept Nutr & Dietet, Amsterdam, Netherlands.
   [Walrabenstein, Wendy; Wagenaar, Carlijn A.; van de Put, Marieke; van der Leeden, Marike; Gerritsen, Martijn; Twisk, Jos W. R.; van der Esch, Martin; van Middendorp, Henriet; Weijs, Peter J. M.; Roorda, Leo D.; van Schaardenburg, Dirkjan] Amsterdam Rehabil Res Ctr Reade, Amsterdam, Netherlands.
   [Walrabenstein, Wendy] Reade Ctr Rheumatol & Rehabil, Dr Jan Breemenstr 2, NL-1056 AB Amsterdam, Netherlands.
C3 University of Amsterdam; Vrije Universiteit Amsterdam; University of
   Amsterdam; Vrije Universiteit Amsterdam; Vrije Universiteit Amsterdam;
   University of Amsterdam; Leiden University; Leiden University - Excl
   LUMC; Vrije Universiteit Amsterdam; University of Amsterdam
RP Walrabenstein, W (corresponding author), Reade Ctr Rheumatol & Rehabil, Dr Jan Breemenstr 2, NL-1056 AB Amsterdam, Netherlands.
EM w.walrabenstein@reade.nl
RI van Middendorp, Henriet/B-8300-2013
OI van Middendorp, Henriet/0000-0003-4575-0895; Walrabenstein,
   Wendy/0000-0002-2428-2845; Wagenaar, Carlijn/0000-0002-0937-4450
FU Reade (Amsterdam, the Netherlands); Reade Foundation (Amsterdam, the
   Netherlands); Stichting Vermeer 14 (private foundation, Amsterdam, the
   Netherlands); W.M. de Hoop Stichting (private foundation, Bussum, the
   Netherlands); Netherlands Organisation for Health Research and
   Development (ZonMw) [555003210]
FX The RCT is funded by Reade (Amsterdam, the Netherlands) , Reade
   Foundation (Amsterdam, the Netherlands) , Stichting Vermeer 14 (private
   foundation, Amsterdam, the Netherlands) , and W.M. de Hoop Stichting
   (private foundation, Bussum, the Netherlands) . The position of Carlijn
   Wagenaar is funded by The Netherlands Organisation for Health Research
   and Development (ZonMw) no. 555003210.
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NR 54
TC 18
Z9 18
U1 1
U2 6
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 1063-4584
EI 1522-9653
J9 OSTEOARTHR CARTILAGE
JI Osteoarthritis Cartilage
PD NOV
PY 2023
VL 31
IS 11
BP 1491
EP 1500
DI 10.1016/j.joca.2023.05.014
EA OCT 2023
PG 10
WC Orthopedics; Rheumatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Rheumatology
GA Y6LL0
UT WOS:001106353200001
PM 37328047
OA hybrid
DA 2025-06-11
ER

PT J
AU Patel, SA
   Dhillon, PK
   Kondal, D
   Jeemon, P
   Kahol, K
   Manimunda, SP
   Purty, AJ
   Deshpande, A
   Negi, PC
   Ladhani, S
   Toteja, GS
   Patel, V
   Prabhakaran, D
AF Patel, Shivani A.
   Dhillon, Preet K.
   Kondal, Dimple
   Jeemon, Panniyammakal
   Kahol, Kashvi
   Manimunda, Sathya Prakash
   Purty, Anil J.
   Deshpande, Ajit
   Negi, P. C.
   Ladhani, Sulaiman
   Toteja, Gurudayal Singh
   Patel, Vikram
   Prabhakaran, Dorairaj
TI Chronic disease concordance within Indian households: A cross-sectional
   study
SO PLOS MEDICINE
LA English
DT Article
ID METABOLIC SYNDROME; FAMILIAL AGGREGATION; SPOUSAL CONCORDANCE;
   MARRIED-COUPLES; CORONARY RISK; HEALTH; HEART; COMPONENTS; ADULTS
AB Background
   The household is a potentially important but understudied unit of analysis and intervention in chronic disease research. We sought to estimate the association between living with someone with a chronic condition and one's own chronic condition status.
   Methods and findings
   We conducted a cross-sectional analysis of population-based household-and individual-level data collected in 4 socioculturally and geographically diverse settings across rural and urban India in 2013 and 2014. Of 10,703 adults ages 18 years and older with coresiding household members surveyed, data from 7,522 adults (mean age 39 years) in 2,574 households with complete covariate information were analyzed. The main outcome measures were diabetes (fasting plasma glucose >= 126 mg/dL or taking medication), common mental disorder (General Health Questionnaire score >= 12), hypertension (blood pressure >= 140/90 mmHg or taking medication), obesity (body mass index >= 30 kg/m(2)), and high cholesterol (total blood cholesterol >= 240 mg/dL or taking medication). Logistic regression with generalized estimating equations was used to model associations with adjustment for a participant's age, sex, education, marital status, religion, and study site. Inverse probability weighting was applied to account for missing data. We found that 44% of adults had 1 or more of the chronic conditions examined. Irrespective of familial relationship, adults who resided with another adult with any chronic condition had 29% higher adjusted relative odds of having 1 or more chronic conditions themselves (adjusted odds ratio [aOR] = 1.29; 95% confidence interval [95% CI] 1.10-1.50). We also observed positive statistically significant associations of diabetes, common mental disorder, and hypertension with any chronic condition (aORs ranging from 1.19 to 1.61) in the analysis of all coresiding household members. Associations, however, were stronger for concordance of certain chronic conditions among coresiding household members. Specifically, we observed positive statistically significant associations between living with another adult with diabetes (aOR = 1.60; 95% CI 1.23-2.07), common mental disorder (aOR = 2.69; 95% CI 2.12-3.42), or obesity (aOR = 1.82; 95% CI 1.33-2.50) and having the same condition. Among separate analyses of dyads of parents and their adult children and dyads of spouses, the concordance between the chronic disease status was striking. The associations between common mental disorder, hypertension, obesity, and high cholesterol in parents and those same conditions in their adult children were aOR = 2.20 (95% CI 1.28-3.77), 1.58 (95% CI 1.15-2.16), 4.99 (95% CI 2.71-9.20), and 2.57 (95% CI 1.15-5.73), respectively. The associations between diabetes and common mental disorder in husbands and those same conditions in their wives were aORs = 2.28 (95% CI 1.52-3.42) and 3.01 (95% CI 2.01-4.52), respectively. Relative odds were raised even across different chronic condition phenotypes; specifically, we observed positive statistically significant associations between hypertension and obesity in the total sample of all coresiding adults (aOR = 1.24; 95% CI 1.02-1.52), high cholesterol and diabetes in the adult-parent sample (aOR = 2.02; 95% CI 1.08-3.78), and hypertension and diabetes in the spousal sample (aOR = 1.51; 95% CI 1.05-2.17). Of all associations examined, only the relationship between hypertension and diabetes in the adult-parent dyads was statistically significantly negative (aOR = 0.62; 95% CI 0.40-0.94). Relatively small samples in the dyadic analysis and site-specific analysis call for caution in interpreting qualitative differences between associations among different dyad types and geographical locations.
   Because of the cross-sectional nature of the analysis, the findings do not provide information on the etiology of incident chronic conditions among household members.
   Conclusions
   We observed strong concordance of chronic conditions within coresiding adults across diverse settings in India. These data provide early evidence that a household-based approach to chronic disease research may advance public health strategies to prevent and control chronic conditions.
C1 [Patel, Shivani A.; Kondal, Dimple; Prabhakaran, Dorairaj] Ctr Chron Dis Control, Gurugram, Haryana, India.
   [Patel, Shivani A.] Emory Univ, Hubert Dept Global Hlth, Atlanta, GA 30322 USA.
   [Dhillon, Preet K.; Kondal, Dimple; Jeemon, Panniyammakal; Kahol, Kashvi; Patel, Vikram; Prabhakaran, Dorairaj] Publ Hlth Fdn India, Gurugram, Haryana, India.
   [Manimunda, Sathya Prakash] Indian Council Med Res, Natl Ctr Dis Informat & Res, Bengaluru, India.
   [Purty, Anil J.] Pondicherry Inst Med Sci, Kalapet, Puducherry, India.
   [Deshpande, Ajit] Sri Aurobindo Inst Med Sci, Indore, Madhya Pradesh, India.
   [Negi, P. C.] Indira Gandhi Med Coll, Shimla, Himachal Prades, India.
   [Ladhani, Sulaiman] Aga Khan Hlth Serv, Bombay, Maharashtra, India.
   [Toteja, Gurudayal Singh] Indian Council Med Res, New Delhi, India.
   [Patel, Vikram] Harvard Med Sch, Dept Global Hlth & Social Med, Boston, MA USA.
   [Jeemon, Panniyammakal] Sree Chitra Tirunal Inst Med Sci & Technol, Trivandrum, Kerala, India.
C3 Emory University; Public Health Foundation of India; Indian Council of
   Medical Research (ICMR); ICMR - National Centre for Disease Informatics
   & Research (NCDIR); Pondicherry Institute of Medical Sciences; Indira
   Gandhi Medical College & Hospital Shimla; Indian Council of Medical
   Research (ICMR); Harvard University; Harvard Medical School; Department
   of Science & Technology (India); Sree Chitra Tirunal Institute for
   Medical Sciences Technology (SCTIMST)
RP Patel, SA (corresponding author), Ctr Chron Dis Control, Gurugram, Haryana, India.; Patel, SA (corresponding author), Emory Univ, Hubert Dept Global Hlth, Atlanta, GA 30322 USA.
EM s.a.patel@emory.edu
RI Patel, Vikram/ADE-3787-2022; Prabhakaran, Dorairaj/B-4147-2011
OI Patel, Shivani/0000-0003-0082-5857; Jeemon,
   Panniyammakal/0000-0003-4172-4307; Prabhakaran,
   Dorairaj/0000-0002-3172-834X
FU Division of Reproductive Health and Nutrition of Indian Council of
   Medical Research [RHN/NTF/4/2011-2012]; Division of Reproductive Health
   and Nutrition of Indian Council of Medical Research
   [RHN/NTF/4/2011-2012]
FX The data collection was funded by the Division of Reproductive Health
   and Nutrition of Indian Council of Medical Research
   (http://icmr.nic.in/) vide grant RFC NO: RHN/NTF/4/2011-2012 dated
   28.03.2012. The authors received no specific funding for this
   manuscript.
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NR 45
TC 40
Z9 44
U1 0
U2 11
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1549-1277
EI 1549-1676
J9 PLOS MED
JI PLos Med.
PD SEP
PY 2017
VL 14
IS 9
AR e1002395
DI 10.1371/journal.pmed.1002395
PG 16
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA FI4TS
UT WOS:000411970300015
PM 28961237
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Fazelian, S
   Paknahad, Z
   Khajehali, L
   Kheiri, S
   Amani, R
AF Fazelian, Siavash
   Paknahad, Zamzam
   Khajehali, Leila
   Kheiri, Soleiman
   Amani, Reza
TI The effects of supplementation with vitamin D on inflammatory
   biomarkers, omentin, and vaspin in women with type 2 diabetes: A
   randomized double-blind placebo-controlled clinical trial
SO JOURNAL OF FOOD BIOCHEMISTRY
LA English
DT Article
DE diabetes; hs-CRP; Omentin; vaspin; vitamin D; women
ID ADIPOSE-TISSUE; INSULIN-RESISTANCE; METABOLIC SYNDROME; GLYCEMIC
   CONTROL; ANXIETY; ADIPOCYTOKINE; ASSOCIATION; POPULATION; PREVALENCE;
   CALCIUM
AB Type 2 diabetes (T2DM) is a global problem that increases the risk of inflammation and hormonal dysfunction. The purpose of this study was to determine the effect of vitamin D on inflammatory biomarkers, omentin, and vaspin in diabetic women with anxiety. In this study, 51 women with T2DM were allocated to receive one oral pearl of 50,000 IU vitamin D-3(26) or a placebo (25) fortnightly for 16 weeks. Anthropometric indices, dietary intake, high sensitivity C-reactive protein (hs-CRP), Interleukin 10 (IL-10), vaspin, and omentin were measured at the baseline and after 16-weeks supplementation. Serum hs-CRP was reduced (p = 0.01) and IL-10 concentrations was increased (p = 0.04) in intervention group. Vitamin D marginally increased serum levels of omentin (p = 0.06), however, vaspin did not change post-intervention. According to subgroup analysis, omentin levels increased significantly in participants with lower baseline serum vitamin D (p = 0.008). Vitamin D can improve anti-inflammatory biomarkers in diabetic patients.
C1 [Fazelian, Siavash; Paknahad, Zamzam; Amani, Reza] Isfahan Univ Med Sci, Sch Nutr & Food Sci, Food Secur Res Ctr, Dept Clin Nutr, Esfahan, Iran.
   [Khajehali, Leila] Imam Ali Hosp Farokhshahr, Social Secur Org, Shahrekord, Iran.
   [Kheiri, Soleiman] Shahrekord Univ Med Sci, Sch Hlth, Dept Epidemiol, Shahrekord, Iran.
   [Kheiri, Soleiman] Shahrekord Univ Med Sci, Sch Hlth, Dept Biostat, Shahrekord, Iran.
C3 Isfahan University of Medical Sciences; Shahrekord University Medical
   Sciences; Shahrekord University Medical Sciences
RP Amani, R (corresponding author), Isfahan Univ Med Sci, Sch Nutr & Food Sci, Food Secur Res Ctr, Dept Clin Nutr, Esfahan, Iran.
EM r_amani@nutr.mui.ac.ir
RI paknahad, zamzam/E-6191-2012; Kheiri, Soleiman/K-2401-2017; Amani,
   Reza/U-7483-2017
OI Amani, Reza/0000-0002-0074-4080; paknahad, zamzam/0000-0002-1864-2576
FU Isfahan University of Medical Sciences
FX This paper was a part of Siavash Fazelain's Ph.D dissertation. The costs
   of laboratory tests were covered by a grant provided by Vice-Chancellor
   for Research, Isfahan University of Medical Sciences. Hereby, the
   authors wish to acknowledge all participants for their kind cooperation.
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NR 52
TC 8
Z9 8
U1 0
U2 8
PU WILEY-HINDAWI
PI LONDON
PA ADAM HOUSE, 3RD FL, 1 FITZROY SQ, LONDON, WIT 5HE, ENGLAND
SN 0145-8884
EI 1745-4514
J9 J FOOD BIOCHEM
JI J. Food Biochem.
PD DEC
PY 2018
VL 42
IS 6
AR e12631
DI 10.1111/jfbc.12631
PG 9
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA HJ1RP
UT WOS:000456942100006
OA gold
DA 2025-06-11
ER

PT J
AU Agusti, A
   Moya-Pérez, A
   Campillo, I
   Montserrat-de la Paz, S
   Cerrudo, V
   Perez-Villalba, A
   Sanz, Y
AF Agusti, Ana
   Moya-Perez, A.
   Campillo, I.
   Montserrat-de la Paz, S.
   Cerrudo, V.
   Perez-Villalba, A.
   Sanz, Yolanda
TI Bifidobacterium pseudocatenulatum CECT 7765 Ameliorates
   Neuroendocrine Alterations Associated with an Exaggerated Stress
   Response and Anhedonia in Obese Mice
SO MOLECULAR NEUROBIOLOGY
LA English
DT Article
DE Obesity; Bifidobacterium; Microbiota; Depression; Stress; Serotonin;
   TLR2
ID MAJOR DEPRESSIVE DISORDER; UNPREDICTABLE MILD STRESS;
   IRRITABLE-BOWEL-SYNDROME; HIGH-FAT-DIET; BEHAVIORAL ALTERATIONS;
   INTESTINAL MICROBIOTA; METABOLIC SYNDROME; GENE-EXPRESSION; GUT
   MICROBIOTA; SOCIAL STRESS
AB Obesity, besides being a problem of metabolic dysfunction, constitutes a risk factor for psychological disorders. Experimental models of diet-induced obesity have revealed that obese animals are prone to anxious and depressive-like behaviors. The present study aimed to evaluate whether Bifidobacterium pseudocatenulatum CECT 7765 could reverse the neurobehavioral consequences of obesity in a high-fat diet (HFD) fed mouse model via regulation of the gut-brain axis. Adult male wild-type C57BL-6 mice were fed a standard diet or HFD, supplemented with either placebo or the bifidobacterial strain for 13 weeks. Behavioral tests were performed, and immune and neuroendocrine parameters were analyzed including leptin and corticosterone and their receptors, Toll-like receptor 2 (TLR2) and neurotransmitters. We found that obese mice showed anhedonia (p < 0.050) indicative of a depressive-like behavior and an exaggerated hypothalamic-pituitary axis (HPA)-mediated stress response to acute physical (p < 0.001) and social stress (p < 0.050), but these alterations were ameliorated by B. pseudocatenulatum CECT 7765 (p < 0.050). These behavioral effects were parallel to reductions of the obesity-associated hyperleptinemia (p < 0.001) and restoration of leptin signaling (p < 0.050), along with fat mass loss (p < 0.010). B. pseudocatenulatum CECT 7765 administration also led to restoration of the obesity-induced reductions in adrenaline in the hypothalamus (p < 0.010), involved in the hypothalamic control of energy balance. Furthermore, the bifidobacterial strain reduced the obesity-induced upregulation of TLR2 protein or gene expression in the intestine (p < 0.010) and the hippocampus (p < 0.050) and restored the alterations of 5-HT levels in the hippocampus (p < 0.050), which could contribute to attenuating the obesity-associated depressive-like behavior (p < 0.050). In summary, the results indicate that B. pseudocatenulatum CECT 7765 could play a role in depressive behavior comorbid with obesity via regulation of endocrine and immune mediators of the gut-brain axis.
C1 [Agusti, Ana; Moya-Perez, A.; Campillo, I.; Montserrat-de la Paz, S.; Cerrudo, V.; Perez-Villalba, A.; Sanz, Yolanda] CNR, Inst Agrochem & Food Technol, Nutr & Hlth Res Unit, Microbial Ecol,IATA CSIC, C Catedrat Agustin Escardino 7, Paterna Valencia 46980, Spain.
   [Agusti, Ana; Moya-Perez, A.; Campillo, I.; Montserrat-de la Paz, S.; Cerrudo, V.; Perez-Villalba, A.; Sanz, Yolanda] Univ Valencia, Cell Biol Dept, Ctr Invest Biomed Red Enfermedades Neurodegenerat, Valencia, Spain.
C3 Consejo Superior de Investigaciones Cientificas (CSIC); Instituto de
   Agroquimica y Tecnologia de los Alimentos (IATA); University of
   Valencia; CIBERNED
RP Agusti, A; Sanz, Y (corresponding author), CNR, Inst Agrochem & Food Technol, Nutr & Hlth Res Unit, Microbial Ecol,IATA CSIC, C Catedrat Agustin Escardino 7, Paterna Valencia 46980, Spain.; Agusti, A; Sanz, Y (corresponding author), Univ Valencia, Cell Biol Dept, Ctr Invest Biomed Red Enfermedades Neurodegenerat, Valencia, Spain.
EM aagusti@iata.csic.es; yolsanz@iata.csic.es
RI Feliu, Ana/AAB-1445-2020; Perez-Villalba, Ana/HTT-4372-2023; la Paz,
   Sergio/Z-3447-2019; Perez, Ana/L-9214-2014; Sanz, Yolanda/H-5498-2012
OI Montserrat-de la Paz, Sergio/0000-0001-5400-3192; Perez,
   Ana/0000-0002-5330-2374; Agusti, Ana/0000-0001-9005-574X; Sanz,
   Yolanda/0000-0002-1615-1976; Cerrudo, Victor/0000-0003-1678-990X
FU Spanish Ministry of Economy and Competitiveness (MINECO)
   [AGL2014-52101-P]; MECD; MINECO; CIBERNED
FX This work and the contract of AA were supported by grant AGL2014-52101-P
   from the Spanish Ministry of Economy and Competitiveness (MINECO). The
   scholarship of AM from MECD and the PTA contract of IC from MINECO are
   also fully acknowledged. CIBERNED funding AP is also acknowledged.
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NR 74
TC 63
Z9 69
U1 1
U2 34
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0893-7648
EI 1559-1182
J9 MOL NEUROBIOL
JI Mol. Neurobiol.
PD JUN
PY 2018
VL 55
IS 6
BP 5337
EP 5352
DI 10.1007/s12035-017-0768-z
PG 16
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA GF5FI
UT WOS:000431991500064
PM 28921462
DA 2025-06-11
ER

PT J
AU Crosta, ML
   Caldarola, G
   Fraietta, S
   Craba, A
   Benedetti, C
   Coco, V
   Janiri, L
   Rinaldi, L
   De Simone, C
AF Crosta, M. L.
   Caldarola, G.
   Fraietta, S.
   Craba, A.
   Benedetti, C.
   Coco, V.
   Janiri, L.
   Rinaldi, L.
   De Simone, C.
TI Psychopathology and eating disorders in patients with psoriasis
SO GIORNALE ITALIANO DI DERMATOLOGIA E VENEREOLOGIA
LA English
DT Article
DE Psoriasis; Eating disorders; Psychopathology; Obesity
ID QUALITY-OF-LIFE; METABOLIC SYNDROME; DEPRESSION; OBESITY; COMORBIDITIES;
   ASSOCIATION; PREVALENCE; INVENTORY
AB Aim. Psoriasis is a multifactorial chronic inflammatory skin disease that often occurs in patients who are overweight or obese. In literature the connections between obesity and eating disorders are well known, but few studies have investigated the link between eating disorders and psoriasis.
   We hypothesized that Eating Disorders (ED) can be considered a psychogenic cofactors, which contribute to the development of obesity and metabolic syndrome in psoriatic patients, who are frequently prone to psychiatric comorbidity.
   Methods. From January to April 2011 we enrolled 100 consecutive psoriatic outpatients and a control group of 100 selected non-psoriatic outpatients, matched by age, gender, and BMI to the study group. The assessment battery was composed by the Psoriasis Area Severity Index (PASI) score, the Eating Disorder Inventory (EDI) and the Symptom Checklist-90 Revised (SCL-90-R (R)).
   Results. Our data showed that most of EDI and SCL-90R subscales was mostly altered in psoriatic population compared to patients without psoriasis. Moreover, we noticed in patients with psoriasis an association between the progressive weight increase and an impairment on most of EDI subscales.
   Conclusion. Psoriasis is associated with psychopathological traits, which are frequently found in EDs. Since obesity makes psoriasis less susceptible to therapy and weight loss improves drug response, dermatologists should be alert to suspect the presence of this condition.
C1 [Crosta, M. L.; Fraietta, S.; Craba, A.; Janiri, L.; Rinaldi, L.] Univ Cattolica Sacro Cuore, Inst Psychiat, I-00168 Rome, Italy.
   [Caldarola, G.; Benedetti, C.; Coco, V.; De Simone, C.] Univ Cattolica Sacro Cuore, Inst Dermatol, I-00168 Rome, Italy.
C3 Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli;
   Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli
RP Caldarola, G (corresponding author), Sacro Cuore Catholic Univ, Dept Dermatol, Lgo F Vito 8, I-00168 Rome, Italy.
EM giacomocaldarola@libero.it
RI Caldarola, Giacomo/K-9676-2016; Coco, Valeria/ACH-1880-2022
OI Caldarola, Giacomo/0000-0002-8837-9232; Coco,
   Valeria/0000-0001-7557-5587; de simone, clara/0000-0002-0898-0045
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NR 36
TC 14
Z9 14
U1 0
U2 4
PU EDIZIONI MINERVA MEDICA
PI TURIN
PA CORSO BRAMANTE 83-85 INT JOURNALS DEPT., 10126 TURIN, ITALY
SN 0392-0488
EI 1827-1820
J9 GIORN ITAL DERMAT V
JI G. Ital. Dermatol. Venereol.
PD JUN
PY 2014
VL 149
IS 3
BP 355
EP 361
PG 7
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology
GA AM6YP
UT WOS:000340012200010
PM 24819764
DA 2025-06-11
ER

PT J
AU Astiz, M
   Oster, H
AF Astiz, Mariana
   Oster, Henrik
TI Perinatal Programming of Circadian Clock-Stress Crosstalk
SO NEURAL PLASTICITY
LA English
DT Review
ID PITUITARY-ADRENAL AXIS; PRENATAL RESTRAINT STRESS; EARLY-LIFE STRESS;
   REV-ERB-ALPHA; GENE-EXPRESSION; GLUCOCORTICOID-RECEPTOR; SUPRACHIASMATIC
   NUCLEUS; EMBRYONIC-DEVELOPMENT; METABOLIC SYNDROME; PERIPHERAL CLOCKS
AB An intact communication between circadian clocks and the stress system is important for maintaining physiological homeostasis under resting conditions and in response to external stimuli. There is accumulating evidence for a reciprocal interaction between both-from the systemic to the molecular level. Disruption of this interaction by external factors such as shiftwork, jetlag, or chronic stress increases the risk of developing metabolic, immune, or mood disorders. From experiments in rodents, we know that both systems maturate during the perinatal period. During that time, exogenous factors such as stress or alterations in the external photoperiod may critically affect-or program-physiological functions later in life. This developmental programming process has been attributed to maternal stress signals reaching the embryo, which lastingly change gene expression through the induction of epigenetic mechanisms. Despite the well-known function of the adult circadian system in temporal coordination of physiology and behavior, the role of maternal and embryonic circadian clocks during pregnancy and postnatal development is still poorly defined. A better understanding of the circadian-stress crosstalk at different periods of development may help to improve stress resistance and devise preventive and therapeutic strategies against chronic stress-associated disorders.
C1 [Astiz, Mariana; Oster, Henrik] Univ Lubeck, Ctr Brain Behav & Metab, Inst Neurobiol, Marie Curie St, D-23562 Lubeck, Germany.
C3 University of Lubeck
RP Oster, H (corresponding author), Univ Lubeck, Ctr Brain Behav & Metab, Inst Neurobiol, Marie Curie St, D-23562 Lubeck, Germany.
EM henrik.oster@uksh.de
RI Oster, Henrik/O-4426-2019; Oster, Henrik/D-2335-2013
OI Astiz, Mariana/0000-0001-9912-1686; Oster, Henrik/0000-0002-1414-7068
FU German Research Foundation (DFG) [SFB-134, GRK-1957]; Volkswagen
   Foundation; European Molecular Biology Organization (EMBO);
   International Brain Research Organization (IBRO)
FX The authors thank Drs. C.E. Koch and M.E. Solano for the critical
   revision of the manuscript. This work was supported by grants of the
   German Research Foundation (DFG; SFB-134 and GRK-1957) and the
   Volkswagen Foundation to Henrik Oster and by fellowships of the European
   Molecular Biology Organization (EMBO) and International Brain Research
   Organization (IBRO) to Mariana Astiz.
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NR 147
TC 22
Z9 25
U1 0
U2 13
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2090-5904
EI 1687-5443
J9 NEURAL PLAST
JI Neural. Plast.
PY 2018
VL 2018
AR 5689165
DI 10.1155/2018/5689165
PG 12
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA FW6JD
UT WOS:000425423400001
PM 29593783
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Lynskey, SJ
   Ling, ZH
   Ziemann, M
   Gill, SD
   McGee, SL
   Page, RS
AF Lynskey, Samuel J.
   Ling, Zihui
   Ziemann, Mark
   Gill, Stephen D.
   McGee, Sean L.
   Page, Richard S.
TI Loosening the Lid on Shoulder Osteoarthritis: How the Transcriptome and
   Metabolic Syndrome Correlate with End-Stage Disease
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE transcriptomic analysis; metabolic syndrome; OA; cuff-tear arthropathy;
   rotator cuff arthropathy; ageing
ID KNEE OSTEOARTHRITIS; OSTEOGENIC DIFFERENTIATION; ARTICULAR CHONDROCYTES;
   PLASMA ADIPONECTIN; POSSIBLE MECHANISM; OXIDATIVE STRESS; CROSS-LINKING;
   JOINT DISEASE; STEM-CELL; CARTILAGE
AB Metabolic syndrome (MetS) associated with Osteoarthritis (OA) is an increasingly recognised entity. Whilst the degenerative pattern in cuff-tear arthropathy (CTA) has been well documented, the biological processes behind primary shoulder OA and CTA remain less understood. This study investigates transcriptomic differences in these conditions, alongside the impact of MetS in patients undergoing total shoulder replacement. In a multi-centre study, 20 OA patients undergoing total shoulder replacement were included based on specific treatment indications for OA and cuff-tear arthropathy as well as 25 patients undergoing rotator cuff repair (RCR) as a comparator group. Tissues from subchondral bone, capsule (OA and RCR), and synovium were biopsied, and RNA sequencing was performed using Illumina platforms. Differential gene expression was conducted using DESeq2, adjusting for demographic factors, followed by pathway enrichment using the mitch package. Gene expressions in CTA and primary OA was differentially affected. CTA showed mitochondrial dysfunction, GATD3A downregulation, and increased cartilage degradation, while primary OA was marked by upregulated inflammatory and catabolic pathways. The effect of MetS on these pathologies was further shown. MetS further disrupted WNT/beta-catenin signalling in CTA, and in OA. Genes such as ACAN, PANX3, CLU, and VAT1L were upregulated, highlighting potential biomarkers for early OA detection. This transcriptomic analysis reveals key differences between end-stage CTA and primary glenohumeral OA. CTA shows heightened metabolic/protein synthesis activity with less immune-driven inflammation. Under MetS, mitochondrial dysfunction (including GATD3A downregulation) and altered Wnt/beta-catenin signalling intensify cartilage and bone damage. In contrast, primary OA features strong complement activation, inflammatory gene expression, and collagen remodelling. MetS worsens both conditions via oxidative stress, advanced glycation end products, and ECM disruption-particularly, increased CS/DS degradation. These distinctions support targeted treatments, from antioxidants and Wnt modulators to aggrecanase inhibitors or clusterin augmentation. Addressing specific molecular disruptions, especially those amplified by MetS, may preserve shoulder function, delay surgical intervention, and improve long-term patient outcomes.
C1 [Lynskey, Samuel J.; Gill, Stephen D.; Page, Richard S.] Geelong Univ Hosp, Dept Orthopaed Surg, Geelong, Vic 3220, Australia.
   [Lynskey, Samuel J.; McGee, Sean L.] Deakin Univ, Fac Hlth, Sch Med, Geelong, Vic 3220, Australia.
   [Ling, Zihui] Peninsula Hlth, 2 Hastings Rd, Frankston, Vic 3199, Australia.
   [Ziemann, Mark] Burnet Inst, Melbourne, Vic 3004, Australia.
   [Ziemann, Mark] Deakin Univ, Sch Life & Environm Sci, Pigdons Rd, Geelong, Vic 3216, Australia.
   [Gill, Stephen D.; Page, Richard S.] St John God Hosp, Barwon Ctr Orthopaed Res & Educ BCORE, Geelong, Vic 3220, Australia.
   [Gill, Stephen D.; Page, Richard S.] Deakin Univ, IMPACT Inst Mental & Phys Hlth & Clin Translat, Barwon Hlth, Geelong, Vic 3220, Australia.
C3 Barwon Health; Geelong Hospital; Deakin University; Peninsula Health;
   Burnet Institute; Deakin University; St John of God Health Care; Deakin
   University; Barwon Health
RP Lynskey, SJ (corresponding author), Geelong Univ Hosp, Dept Orthopaed Surg, Geelong, Vic 3220, Australia.; Lynskey, SJ (corresponding author), Deakin Univ, Fac Hlth, Sch Med, Geelong, Vic 3220, Australia.
EM slynskey@deakin.edu.au
RI Page, Richard/K-6327-2015; Ziemann, Mark/ADY-8719-2022; Gill,
   Stephen/AFH-8626-2022
OI Gill, Stephen/0000-0001-8722-0572
FU Australian Orthopaedic Association Research Foundation (AOARF);  [I.D.:
   25-Reg]
FX Funding support for this work was obtained from the Australian
   Orthopaedic Association Research Foundation (AOARF), Grant I.D.: 25-Reg.
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NR 169
TC 0
Z9 0
U1 0
U2 0
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD MAR 28
PY 2025
VL 26
IS 7
AR 3145
DI 10.3390/ijms26073145
PG 32
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 1FO7J
UT WOS:001463847900001
PM 40243895
DA 2025-06-11
ER

PT J
AU Kim, OY
   Song, J
AF Kim, Oh. Yoen
   Song, Juhyun
TI Important roles of linoleic acid and α-linolenic acid in regulating
   cognitive impairment and neuropsychiatric issues in metabolic-related
   dementia
SO LIFE SCIENCES
LA English
DT Article
DE Linoleic acid (LA); alpha-Linolenic acid (ALA); Dementia; Metabolic
   syndrome (MetS); Cognitive impairment
ID POLYUNSATURATED FATTY-ACIDS; HIPPOCAMPAL SYNAPTIC-TRANSMISSION;
   CARDIOVASCULAR RISK-FACTORS; BRAIN-BARRIER PERMEABILITY; TRIGLYCERIDE
   GLUCOSE INDEX; INDUCED INSULIN-RESISTANCE; ALZHEIMERS-DISEASE;
   DOCOSAHEXAENOIC ACID; DIETARY-INTAKE; SATURATED FAT
AB Metabolic syndrome (MetS), which is characterized by insulin resistance, high blood glucose, obesity, and dyslipidemia, is known to increase the risk of dementia accompanied by memory loss and depression. The direct pathways and specific mechanisms in the central nervous system (CNS) for addressing fatty acid imbalances in MetS have not yet been fully elucidated. Among polyunsaturated acids, linoleic acid (LA, n6-PUFA) and alpha-linolenic acid (ALA, n3-PUFA), which are two essential fatty acids that should be provided by food sources (e. g., vegetable oils and seeds), have been reported to regulate various cellular mechanisms including apoptosis, inflammatory responses, mitochondrial biogenesis, and insulin signaling. Furthermore, inadequate intake of LA and ALA is reported to be involved in neuropathology and neuropsychiatric diseases as well as imbalanced metabolic conditions. Herein, we review the roles of LA and ALA on metabolic-related dementia focusing on insulin resistance, dyslipidemia, synaptic plasticity, cognitive function, and neuropsychiatric issues. This review suggests that LA and ALA are important fatty acids for concurrent treatment of both MetS and neurological problems.
C1 [Kim, Oh. Yoen] Dong Univ, Dept Food Sci & Nutr, Pusan, South Korea.
   [Kim, Oh. Yoen] Dong A Univ, Grad Sch, Dept Hlth Sci, Pusan, South Korea.
   [Song, Juhyun] Chonnam Natl Univ, Dept Anat, Med Sch, Seoul, South Korea.
   [Song, Juhyun] Chonnam Natl Univ, Dept Anat, Med Sch, Hwasun 58128, Jeonranamdo, South Korea.
C3 Dong-Eui University; Dong A University; Chonnam National University;
   Chonnam National University
RP Song, J (corresponding author), Chonnam Natl Univ, Dept Anat, Med Sch, Seoul, South Korea.; Song, J (corresponding author), Chonnam Natl Univ, Dept Anat, Med Sch, Hwasun 58128, Jeonranamdo, South Korea.
EM oykim@dau.ac.kr; juhyunsong@chonnam.ac.kr
RI Kim, Oh/AAA-6492-2022
FU National Research Foundation of Korea (NRF) , South Korea
   [NRF-2022R1A2C1006125, NRF-2022R1A2C1010398]
FX This study was supported by grant NRF-2022R1A2C1006125 (Juhyun Song) and
   NRF-2022R1A2C1010398 (Oh Yoen Kim) from the National Research Foundation
   of Korea (NRF) , South Korea. The authors thank Biorender for making the
   figures.
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NR 385
TC 30
Z9 30
U1 8
U2 29
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0024-3205
EI 1879-0631
J9 LIFE SCI
JI Life Sci.
PD JAN 15
PY 2024
VL 337
AR 122356
DI 10.1016/j.lfs.2023.122356
EA DEC 2023
PG 17
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA EZ2A2
UT WOS:001142681000001
PM 38123015
OA hybrid
DA 2025-06-11
ER

PT J
AU Eriksson, BE
   Tyni-Lennè, R
   Svedenhag, J
   Hallin, R
   Jensen-Urstad, K
   Jensen-Urstad, M
   Bergman, K
   Sylvén, C
AF Eriksson, BE
   Tyni-Lennè, R
   Svedenhag, J
   Hallin, R
   Jensen-Urstad, K
   Jensen-Urstad, M
   Bergman, K
   Sylvén, C
TI Physical training in Syndrome X -: Physical training counteracts
   deconditioning and pain in Syndrome X
SO JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
LA English
DT Article
ID NORMAL CORONARY ARTERIOGRAMS; CHEST PAIN; ANGINA-PECTORIS;
   ATHEROSCLEROSIS; ANGIOGRAMS; ADENOSINE; ARTERIES; STRESS
AB OBJECTIVES The aim of this study was to evaluate the effects of exercise training and body-awareness training in female patients with Syndrome X.
   BACKGROUND Patients with Syndrome X, defined as effort-induced angina pectoris, a positive exercise test and a normal coronary angiogram, suffer from a chronic pain disorder. We hypothesized that this disorder results in physical deconditioning with decreased exertional pain threshold.
   METHODS Twenty-six patients were randomly assigned to two training groups (A, B) and a control group (C). Group A (n = 8) started, after baseline measurements, with eight weeks of body-awareness training followed by eight weeks of exercise training on a bicycle ergometer three times a week for 30 min at an intensity of 50% of peak work rate. Group B (n = 8) performed only eight weeks of exercise training. Group C (n = 10) acted as controls without any intervention whatsoever. The effects on exercise performance, hormonal secretion, vascular function, adenosine sensitivity and quality of life were evaluated.
   RESULTS Body-awareness training did not change the pain response. The two training groups did not differ in effects of exercise training. Exercise capacity before training was below the gender- and age-matched reference range and improved by 34% with training to a level not different from the reference range. Onset of pain was delayed by 100% from 3 +/- 2 to 6 +/- 3 min (p ( < 0.05) while maximum pain did not change. Thus the: pain-response-to-exercise curve was shifted to the right. Syndrome X patients showed a hypersensitivity to loll-dose adenosine infusion compared to healthy age- and gender-matched controls (p < 0.0001) that did not change with exercise training. Endothelium-dependent blood flow increase was at baseline within reference range and tended to increase (p < 0.06) following training. In Group A the concentration of cortisol in urine decreased by 53% after body-awareness training (p < 0.05), and this change from baseline remained after physical exercise training (p < 0.05). A similar decrease occurred with only exercise training (Group B).
   CONCLUSIONS Physical deconditioning with lower exertional threshold for pain is a prominent feature in Syndrome X. Physical training in Syndrome X results in an increased exercise capacity with lesser anginal pain. We suggest physical training as an effective treatment in Syndrome X. (C) 2000 by the American College of Cardiology.
C1 Huddinge Univ Hosp, Dept Cardiol, S-14189 Stockholm, Sweden.
   Huddinge Univ Hosp, Dept Physiotherapy, S-14189 Stockholm, Sweden.
   Huddinge Univ Hosp, Dept Clin Physiol, S-14189 Stockholm, Sweden.
   Huddinge Univ Hosp, Dept Neurophysiol, S-14189 Stockholm, Sweden.
   South Hosp, Dept Clin Physiol, Stockholm, Sweden.
C3 Karolinska Institutet; Karolinska Institutet; Karolinska Institutet;
   Karolinska Institutet
RP Eriksson, BE (corresponding author), Huddinge Univ Hosp, Dept Cardiol, S-14189 Stockholm, Sweden.
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NR 27
TC 72
Z9 77
U1 0
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 USA
SN 0735-1097
J9 J AM COLL CARDIOL
JI J. Am. Coll. Cardiol.
PD NOV 1
PY 2000
VL 36
IS 5
BP 1619
EP 1625
DI 10.1016/S0735-1097(00)00931-1
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 371GY
UT WOS:000165171500026
PM 11079667
DA 2025-06-11
ER

PT J
AU Zhu, LY
   Ruan, XY
   Wang, JQ
   Yan, YX
   Tang, CY
   Xu, YW
AF Zhu, Linying
   Ruan, Xiaoyi
   Wang, Jianqi
   Yan, Yongxing
   Tang, Chunyuan
   Xu, Yuanwen
TI Higher oxidative balance score is linearly associated with reduced
   prevalence of chronic kidney disease in individuals with metabolic
   syndrome: evidence from NHANES 1999-2018
SO FRONTIERS IN NUTRITION
LA English
DT Article
DE oxidative balance score; oxidative stress; metabolic syndrome; chronic
   kidney disease; NHANES
ID RISK; DEFINITION; MORTALITY; SMOKING
AB Background: Oxidative stress is a key contributor to the development of chronic kidney disease (CKD) in individuals with metabolic syndrome (MetS). The oxidative balance score (OBS) is an emerging composite assessment tool for dietary and lifestyle oxidative balance. We aimed to explore the association of OBS with CKD prevalence in MetS in this national cross-sectional analysis. Methods: This was a national cross-sectional analysis. Eligible MetS participants >= 20 years of age from NHANES 1999-2018 were included. OBS was assessed according to previous well-validated methods and consisted of 16 dietary components and 4 lifestyle components. MetS was diagnosed by NCEP-ATP III criteria, while CKD was diagnosed by KDIGO 2021 Clinical Practice Guideline. Multivariate logistic regression models were used to explore the association of OBS with CKD in MetS in this national cross-sectional analysis. Results: A total of 8,095 MetS participants were included, with a CKD prevalence of 24.8%. In fully adjusted models, each score increases in OBS, dietary OBS, and lifestyle OBS was associated with a 2, 1.7, and 7.3% reduction in the prevalence of CKD, respectively. Higher OBS, dietary OBS, and lifestyle OBS were all associated with significantly lower odds of CKD (p for trend all <0.05). Restricted cubic spline analysis showed that these associations all exhibited inverse dose-response. Interaction analyses indicated that cardiovascular disease (CVD) status significantly influenced the impact of OBS and dietary OBS, and these associations were only present in CVD-free subjects. Defining MetS using the IDF criteria did not significantly change the results. Conclusion: OBS was inversely associated with the prevalence of CKD in MetS, especially in CVD-free settings. These findings emphasize that adherence to an antioxidant diet and lifestyle contributes to the early prevention of CKD in the MetS population and necessitates attention to CVD interactions. Future prospective cohort studies are needed to confirm these results.
C1 [Zhu, Linying; Yan, Yongxing] Guangdong Med Univ, Sch Obstet & Pediat, Zhanjiang, Guangdong, Peoples R China.
   [Ruan, Xiaoyi; Wang, Jianqi] Guangdong Med Univ, Clin Coll 1, Zhanjiang, Guangdong, Peoples R China.
   [Tang, Chunyuan; Xu, Yuanwen] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Nephrol, Guangzhou, Guangdong, Peoples R China.
C3 Guangdong Medical University; Guangdong Medical University; Sun Yat Sen
   University
RP Tang, CY; Xu, YW (corresponding author), Sun Yat Sen Univ, Affiliated Hosp 1, Dept Nephrol, Guangzhou, Guangdong, Peoples R China.
EM tchuny@mail.sysu.edu.cn; xuyw@mail.sysu.edu.cn
RI Wang, Jianqi/M-6380-2013
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NR 50
TC 0
Z9 0
U1 3
U2 5
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD SEP 30
PY 2024
VL 11
AR 1442274
DI 10.3389/fnut.2024.1442274
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA J2M1P
UT WOS:001335450800001
PM 39403399
OA gold
DA 2025-06-11
ER

PT J
AU Alokail, MS
   Al-Daghri, N
   Abdulkareem, A
   Draz, HM
   Yakout, SM
   Alnaami, AM
   Sabico, S
   Alenad, AM
   Chrousos, GP
AF Alokail, Majed S.
   Al-Daghri, Nasser
   Abdulkareem, Amal
   Draz, Hossam M.
   Yakout, Sobhy M.
   Alnaami, Abdullah M.
   Sabico, Shaun
   Alenad, Amal M.
   Chrousos, George P.
TI Metabolic syndrome biomarkers and early breast cancer in Saudi women:
   evidence for the presence of a systemic stress response and/or a
   pre-existing metabolic syndrome-related neoplasia risk?
SO BMC CANCER
LA English
DT Article
DE Breast cancer; Saudi women; Adiponectin; Leptin; HDL
ID DENSITY-LIPOPROTEIN CHOLESTEROL; RENIN-ANGIOTENSIN SYSTEM;
   POSTMENOPAUSAL WOMEN; INSULIN-RESISTANCE; INFLAMMATORY MARKERS;
   ADIPONECTIN LEVELS; DIABETES-MELLITUS; ADIPOSE-TISSUE; OBESITY; COHORT
AB Background: Obesity has been linked to many adverse health consequences, including breast cancer. This study aims to determine adipocytokine and other biological changes in recently diagnosed breast cancer patients before therapy is started.
   Methods: A total of 109 female Saudi subjects [56 newly diagnosed, treatment-naive, histologically-confirmed breast cancer cases and 53 age- and BMI-matched controls] were enrolled in this study. Anthropometric data were collected. Serum insulin, adipocytokines and plasminogen activator inhibitor-1 (PAI-1) concentrations were measured using a customized multiplex Luminex assay. Hypersensitive C-Reactive Protein (CRP), tumor necrosis factor-alpha (TNF-alpha), and angiotensin II (ANG II) were measured using ELISA.
   Results: A few days in the diagnosis, breast cancer subjects had significantly higher systolic blood pressure (p = 0.03), glucose (p = 0.01), triglycerides (p = 0.001), leptin (p = 0.044), resistin (p = 0.04), ANG II (p = 0.02), TNF-alpha (p = 0.045), and CRP (p = 0.04) than the controls. On the other hand, HDL (p = 0.01) and adiponectin (p = 0.02) were significantly lower in cancer subjects than controls. A significant association was found between elevated triglycerides (TG) and breast cancer [OR (95% CI), 6.1(1.8, 15.6), p = 0.004], as well as elevated ANG II [OR (95% CI), 5.2(1.2, 14.3), p = 0.03]. On the other hand, aPAI and HDL correlated negatively with breast cancer [OR (95% CI), 0.076(0.01, 0.34), p = 0.001; 0.30(0.09, 0.95), p 0.04, respectively].
   Conclusion: Circulating ANGII and triglycerides were positively associated with early breast cancer. In contrast, HDL-cholesterol correlated negatively with ANG II and aPAI in these patients. This suggests that patients with recently diagnosed breast cancer have biochemical changes consistent with an activated stress response and/or that patients with metabolic syndrome manifestations have a higher risk of developing this disease.
C1 [Alokail, Majed S.; Al-Daghri, Nasser; Draz, Hossam M.; Yakout, Sobhy M.; Alnaami, Abdullah M.; Sabico, Shaun; Chrousos, George P.] King Saud Univ, Coll Sci, Dept Biochem, Biomarkers Res Program, Riyadh 11451, Saudi Arabia.
   [Alokail, Majed S.; Al-Daghri, Nasser] King Saud Univ, Ctr Excellence Biotechnol, Riyadh 11451, Saudi Arabia.
   [Abdulkareem, Amal] King Saud Univ, Coll Med, Dept Surg, Riyadh 11472, Saudi Arabia.
   [Draz, Hossam M.] Natl Res Ctr, Dept Biochem, Cairo 12311, Egypt.
   [Alenad, Amal M.] Univ Southampton, Sch Biol Sci, Southampton SO17 1BJ, Hants, England.
   [Chrousos, George P.] Univ Athens, Sch Med, Dept Pediat 1, Athens 11527, Greece.
   [Al-Daghri, Nasser] King Saud Univ, Coll Sci, Dept Biochem, Riyadh 11451, Saudi Arabia.
C3 King Saud University; King Saud University; King Saud University;
   Egyptian Knowledge Bank (EKB); National Research Centre (NRC);
   University of Southampton; National & Kapodistrian University of Athens;
   Athens Medical School; King Saud University
RP Al-Daghri, N (corresponding author), King Saud Univ, Coll Sci, Dept Biochem, Biomarkers Res Program, Riyadh 11451, Saudi Arabia.
EM aldaghri2011@gmail.com
RI Alnaami, Abdullah/LOR-5409-2024; Al-Daghri, Nasser/A-8360-2011; YAKOUT,
   SOBHY/F-1106-2019; Alenad, Amal/MXM-4730-2025; Al-okail,
   Majed/E-5565-2016; Chrousos, George/G-8702-2011; Sabico,
   Shaun/C-9086-2011
OI Sabico, Shaun/0000-0002-5248-2350; Al-Daghri,
   Nasser/0000-0001-5472-1725; Draz, Hossam/0000-0002-7351-3339
FU King Abdul Aziz City for Science and Technology (KACST), Riyadh, Saudi
   Arabia [AT-28-94]
FX This study was generously funded by King Abdul Aziz City for Science and
   Technology (KACST), (project # AT-28-94) Riyadh, Saudi Arabia. The
   authors thank Mr. Benjamin Vinodson and Mr. SaimUlhaq for the
   statistical analyses of the data.
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NR 44
TC 43
Z9 47
U1 0
U2 17
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-2407
J9 BMC CANCER
JI BMC Cancer
PD FEB 4
PY 2013
VL 13
AR 54
DI 10.1186/1471-2407-13-54
PG 6
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA 088BE
UT WOS:000314808000001
PM 23374911
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Riccardi, G
   Aggett, P
   Brighenti, F
   Delzenne, N
   Frayn, K
   Nieuwenhuizen, A
   Pannemans, D
   Theis, S
   Tuijtelaars, S
   Vessby, B
AF Riccardi, G
   Aggett, P
   Brighenti, F
   Delzenne, N
   Frayn, K
   Nieuwenhuizen, A
   Pannemans, D
   Theis, S
   Tuijtelaars, S
   Vessby, B
TI PASSCLAIM - Body weight regulation, insulin sensitivity and diabetes
   risk
SO EUROPEAN JOURNAL OF NUTRITION
LA English
DT Review
DE diet; functional foods; insulin sensitivity; insulin resistance;
   obesity; metabolic syndrome; type 2 diabetes
ID CORONARY-HEART-DISEASE; FREE FATTY-ACIDS; MUSCLE GLYCOGEN-SYNTHESIS;
   ENDOTHELIAL DYSFUNCTION; ENERGY-EXPENDITURE; GLUCOSE-METABOLISM;
   OXIDATIVE STRESS; GLYCEMIC INDEX; ADIPOSE-TISSUE; SKELETAL-MUSCLE
AB Background Insulin sensitivity is a key function in human metabolism because it has a crucial role in the development of disease that are increasingly common in modern society. Impaired insulin sensitivity is an important determinant of type 2 diabetes; moreover, it has been proposed as an independent risk factor for cardiovascular disease. Thus, reduced insulin sensitivity is strongly associated with the metabolic syndrome, which represents a cluster of metabolic abnormalities and cardiovascular risk factor. Insulin sensitivity can be modulated by different environmental factors, including dietary habits. Obesity, especially if associated with abdominal adiposity, impairs insulin-sensitivity while physical activity can improve it; however, the composition of the habitual diet is clearly an important regulator of this function. Aim To evaluate methodologies and markers that can be used to substantiate existing and potential claims of beneficial effects of foods on relevant functions connected with body fat deposition, insulin sensitivity and blood glucose regulation. Results We have reviewed the scientific basis for existing and potential claims, based not only on modifications of the target functions (body fat deposition, insulin sensitivity and blood glucose regulation) but also on modifications of other relevant associated functions (energy intake, energy expenditure, fat storage and oxidation, lipotoxicity, body fat composition, inflammation, oxidative stress, vascular function, glucose production and utilization). In this context we have identified a number of markers and evaluated appropriate method to measure and validate them. Conclusions Relevant functions contributing to overweight, the metabolic syndrome and diabetes have been identified. The evidence reviewed indicates that in this field the link between nutrition, biological responses and diseases is clearly established. Therefore, there is a stromg potential to develop functional food science. The major gap in the evidence continues to be the lack of diet based intervention trials of sufficient duration to be relevant for affecting the natural history of these conditions.
C1 ILSI Europe, B-1200 Brussels, Belgium.
   Uppsala Univ, Dept Publ Hlth & Caring Sci Geriatr, Unit Clin Nutr Res, S-75125 Uppsala, Sweden.
   Sudzucker AG, ZAFES, D-67283 Obrigheim, Germany.
   Univ Naples Federico II, Dipartimento Med Clin & Sperimentale, I-80131 Naples, Italy.
   Univ Cent Lancashire, Lancashire Sch Hlth & Postgrad Med, Preston PR1 2HE, Lancs, England.
   Univ Parma, Inst Hyg, Chair Human Nutr, I-43100 Parma, Italy.
   Catholic Univ Louvain, Dept Pharmaceut Sci, Unite PMNT, B-1200 Brussels, Belgium.
   Univ Oxford, Churchill Hosp, Oxford OX3 7LJ, England.
   Numico Res, NL-6700 CA Wageningen, Netherlands.
C3 Uppsala University; University of Naples Federico II; University of
   Central Lancashire; University of Parma; Universite Catholique Louvain;
   University of Oxford; Danone Nutricia; Royal Numico N.V.
RP ILSI Europe, Ave F Mounier 83,Box 6, B-1200 Brussels, Belgium.
EM publications@ilsieurope.be
RI Delzenne, Nathalie/AAC-4628-2019; riccardi, gabriele/A-9269-2012;
   brighenti, furio/E-4174-2010
OI Frayn, Keith/0000-0001-7281-1863; Delzenne,
   Nathalie/0000-0003-2115-6082; brighenti, furio/0000-0001-8441-4611;
   Nieuwenhuizen, Arie/0000-0003-0999-5422
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NR 282
TC 35
Z9 39
U1 1
U2 13
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1436-6207
EI 1436-6215
J9 EUR J NUTR
JI Eur. J. Nutr.
PD JUN
PY 2004
VL 43
SU 2
BP 7
EP 46
DI 10.1007/s00394-004-1202-7
PG 40
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 918QU
UT WOS:000228563500002
PM 15221353
DA 2025-06-11
ER

PT J
AU Zhou, YW
   Li, HG
   Xia, N
AF Zhou, Yawen
   Li, Huige
   Xia, Ning
TI The Interplay Between Adipose Tissue and Vasculature: Role of Oxidative
   Stress in Obesity
SO FRONTIERS IN CARDIOVASCULAR MEDICINE
LA English
DT Review
DE reactive oxygen species; adipokines; antioxidant; perivascular adipose
   tissue; vascular dysfunction
ID NITRIC-OXIDE SYNTHASE; BOUND INHIBITOR BAMBI; HIGH-FAT; ENDOTHELIAL
   DYSFUNCTION; INSULIN-RESISTANCE; BODY-WEIGHT; MITOCHONDRIAL DYSFUNCTION;
   NUTRITIONAL DEFICIENCIES; PROTEIN CARBONYLATION; HYDROGEN-PEROXIDE
AB Cardiovascular diseases (CVDs) rank the leading cause of morbidity and mortality globally. Obesity and its related metabolic syndrome are well-established risk factors for CVDs. Therefore, understanding the pathophysiological role of adipose tissues is of great importance in maintaining cardiovascular health. Oxidative stress, characterized by excessive formation of reactive oxygen species, is a common cellular stress shared by obesity and CVDs. While plenty of literatures have illustrated the vascular oxidative stress, very few have discussed the impact of oxidative stress in adipose tissues. Adipose tissues can communicate with vascular systems, in an endocrine and paracrine manner, through secreting several adipocytokines, which is largely dysregulated in obesity. The aim of this review is to summarize current understanding of the relationship between oxidative stress in obesity and vascular endothelial dysfunction. In this review, we briefly describe the possible causes of oxidative stress in obesity, and the impact of obesity-induced oxidative stress on adipose tissue function. We also summarize the crosstalk between adipose tissue and vasculature mediated by adipocytokines in vascular oxidative stress. In addition, we highlight the potential target mediating adipose tissue oxidative stress.
C1 [Zhou, Yawen; Li, Huige; Xia, Ning] Johannes Gutenberg Univ Med Ctr, Dept Pharmacol, Mainz, Germany.
C3 Johannes Gutenberg University of Mainz
RP Xia, N (corresponding author), Johannes Gutenberg Univ Med Ctr, Dept Pharmacol, Mainz, Germany.
EM xianing@uni-mainz.de
RI Zhou, Chunyan/H-1529-2016; Li, Huige/M-2662-2013; Xia, Dr.,
   Ning/P-3535-2015
OI Li, Huige/0000-0003-3458-7391; Xia, Dr., Ning/0000-0002-5553-1752
FU Deutsche Forschungsgemeinschaft (DFG), Bonn, Germany [LI-1042/1-1,
   LI-1042/3-1, LI-1042/5-1, XI 139/2-1]; Boehringer Ingelheim Foundation
FX Original works from the authors' laboratory contributing to this review
   were supported by grants LI-1042/1-1, LI-1042/3-1, LI-1042/5-1, and XI
   139/2-1 from the Deutsche Forschungsgemeinschaft (DFG), Bonn, Germany.
   HL and NX were supported by a research grant from the Boehringer
   Ingelheim Foundation for the collaborative research consortium Novel and
   neglected cardiovascular risk factors: molecular mechanisms and
   therapeutic implications.
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NR 160
TC 55
Z9 56
U1 1
U2 19
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2297-055X
J9 FRONT CARDIOVASC MED
JI Front. Cardiovasc. Med.
PD MAR 4
PY 2021
VL 8
AR 650214
DI 10.3389/fcvm.2021.650214
PG 14
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA QY0RC
UT WOS:000629751600001
PM 33748199
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Mrowietz, U
   Lauffer, F
   Sondermann, W
   Gerdes, S
   Sewerin, P
AF Mrowietz, Ulrich
   Lauffer, Felix
   Sondermann, Wiebke
   Gerdes, Sascha
   Sewerin, Philipp
TI Psoriasis as a Systemic Disease
SO DEUTSCHES ARZTEBLATT INTERNATIONAL
LA English
DT Review
ID ARTHRITIS; RISK
AB Background: Psoriasis was long regarded as an inflammatory disease limited to the skin. Data from dermatologic, rheumatologic and cardiologic research now show it to be a systemic disease, for which the term psoriatic disease is used. Methods: This paper is based on a selective literature search with special attention to the findings of clinical trials and other current publications, as well as the recommendations of international guidelines. Results: Immunologically mediated inflammation of the skin, arteries, bones, and joints is a central feature of psoriatic disease. Other diseases that are known to be associated with psoriatic disease include hypertension, metabolic syndrome, and depression. The main risk factor for the development of psoriatic disease is obesity, which also increases the likelihood of psoriatic arthritis. The main known trigger factors are stress, infection, and, less commonly, medication. Psoriatic disease is characterized by complex genetics and by a characteristic pattern of inflammation that involves elements of both innate and acquired immunity and, in particular, the cytokines interleukin 17 and 23. The inflammatory processes underlying psoriatic disease can now be targeted with modern biologic and other therapies. Conclusion: In view of the complexity of psoriatic disease, structured management is now recommended so that physicians and patients can work together to determine the optimal treatment strategy.
C1 [Mrowietz, Ulrich; Gerdes, Sascha] Univ Med Ctr Schleswig Holstein, Psoriasis Ctr, Dept Dermatol, Campus Kiel, Kiel, Germany.
   [Lauffer, Felix] Tech Univ Munich, Dept Dermatol & Allergol, Munich, Germany.
   [Sondermann, Wiebke] Univ Hosp Essen, Univ Duisburg Essen, Dept Dermatol, Venereol,Allergol, Essen, Germany.
   [Sewerin, Philipp] Ruhr Univ Bochum, Rheumatol Ctr Ruhr Area, Herne, Germany.
C3 University of Kiel; Schleswig Holstein University Hospital; Technical
   University of Munich; University of Duisburg Essen; Ruhr University
   Bochum
RP Mrowietz, U (corresponding author), Univ Klinikum Schleswig Holstein, Psoriasis Zentrum Zentrum Entzundl Hauterkrankunge, Klin Dermatol Venerol & Allergol, Campus Kiel Arnold Heller Str 3,Haus U27, D-24105 Kiel, Germany.
EM umrowietz@dermatology.uni-kiel.de
RI Sewerin, Philipp/AAG-7717-2020; Gerdes, Sascha/J-4308-2017; Sondermann,
   Wiebke/ACA-9208-2022; mrowietz, ulrich/B-1645-2010
OI mrowietz, ulrich/0000-0002-9539-0712; Mohammed, Shan/0009-0001-8046-1653
FU Novartis; Galapagos; MorphoSys; Almirall; Bristol-Myers-Squibb; AbbVie;
   Lilly; Janssen; Amgen
FX FL has received financial support from Novartis, Galapagos, MorphoSys,
   Almirall, Bristol-Myers-Squibb, AbbVie, Lilly, Janssen, and Amgen. He
   has received honoraria for lectures, presentations, manuscript
   preparation, and continuing medical education events from AbbVie,
   Novartis, LEO Pharma, Lilly, Almirall, Janssen, Amgen, UCB,
   Bristol-Myers-Squibb, and Biogen. He has received reimbursement of
   travel expenses and meeting participation fees from Janssen and UCB. He
   serves on the advisory boards of AbbVie, Novartis, LEO Pharma, Lilly,
   Almirall, Janssen, Amgen, UCB, Bristol-Myers-Squibb, and Union
   Therapeutics.
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NR 40
TC 8
Z9 8
U1 1
U2 2
PU DEUTSCHER AERZTE-VERLAG GMBH
PI COLOGNE
PA DIESELSTRABE 2, POSTFACH 400265, D-50859 COLOGNE, GERMANY
SN 1866-0452
J9 DTSCH ARZTEBL INT
JI Dtsch. Arztebl. Int.
PD JUL 12
PY 2024
VL 121
IS 14
DI 10.3238/arztebl.m2024.0064
PG 10
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA I4H7U
UT WOS:001329890800007
PM 38657176
DA 2025-06-11
ER

PT J
AU Ahmad, P
   Shah, ARN
   Waiz, M
   Chaturvedi, CP
   Alvi, SS
   Khan, MS
AF Ahmad, Parvej
   Shah, Arunim
   Waiz, Mohd
   Chaturvedi, Chandra P.
   Alvi, Sahir Sultan
   Khan, M. Salman
TI Organosulfur Compounds, S-Allyl-L-Cysteine and
   S-Ethyl-L-Cysteine, Target PCSK-9/LDL-R-Axis to Ameliorate
   Cardiovascular, Hepatic, and Metabolic Changes in High Carbohydrate and
   High Fat Diet-Induced Metabolic Syndrome in Rats
SO PHYTOTHERAPY RESEARCH
LA English
DT Article; Early Access
DE high carbohydrate high fat (HCHF)-diet; inflammation; metabolic
   syndrome; organosulfur compounds (OSCs); PCSK-9-LDL-R axis;
   S-Allyl-L-Cysteine and S-Ethyl-L-Cysteine
ID OXIDATIVE-STRESS; IN-VITRO; EXTRACT; LYCOPENE; PCSK-9; ASSAY;
   HYPERTRIGLYCERIDEMIA; ACTIVATION; EXPRESSION; EFFICACY
AB Metabolic syndrome (MetS) is an ever-evolving set of diseases that poses a serious health risk in many countries worldwide. Existing evidence illustrates that individuals with MetS have a 30%-40% higher chance of acquiring type 2 diabetes mellitus (T2DM), cardiovascular disease (CVD), or both. This study was undertaken to uncover the regulatory role of natural organosulfur compounds (OSCs), S-allyl-L-cysteine (SAC), and S-ethyl-L-cysteine (SEC), in targeting high carbohydrate high fat (HCHF)-diet-induced MetS-associated risk management. Our findings suggested that SAC and SEC ameliorated HCHF-diet-induced diabetic profiles, plasma lipid and lipoprotein level, liver function, oxidative-stress, inflammatory cytokines, and chemokines including monocyte chemoattractant protein-1 (MCP-1), lipid peroxidation, plasma proprotein convertase subtilisin/kexin type-9 (PCSK-9), and high-sensitivity C-reactive protein (hs-CRP). Moreover, the assessment of the hepatic mRNA expression of the key genes involved in cholesterol homeostasis depicted that SAC and SEC downregulated the PCSK-9 mRNA expression via targeting the expression of HNF-1 alpha, a transcriptional activator of PCSK-9. On the other hand, the LDL-receptor (LDL-R) expression was upregulated through the activation of its transcriptional regulator sterol regulatory element binding protein-2 (SREBP-2). In addition, the activity and the mRNA expression of 3-hydroxy-3-methylglutaryl coenzyme-A reductases (HMG-R) and peroxisome proliferator-activated receptors (PPARs) were also improved by the treatment of SAC and SEC. We concluded that SAC and SEC can protect against MetS via improving the lipid and lipoprotein content, glycemic indices, hepatic function, targeting the inflammatory cascades, and oxidative imbalance, regulation of the mRNA expression of PCSK-9, LDL-R, SREBP-2, HNF-1 alpha, PPARs, and inflammatory biomarkers.
C1 [Ahmad, Parvej; Waiz, Mohd; Alvi, Sahir Sultan; Khan, M. Salman] Integral Univ, Integral Informat & Res Ctr IIRC 5, Dept Biosci, Clin Biochem & Nat Prod Res Lab, Lucknow, Uttar Pradesh, India.
   [Ahmad, Parvej; Shah, Arunim; Chaturvedi, Chandra P.] Sanjay Gandhi Postgrad Inst Med Sci SGPGIMS, Stem Cell Res Ctr, Dept Hematol, Lucknow, Uttar Pradesh, India.
   [Alvi, Sahir Sultan] Univ Texas Rio Grande Valley, Sch Med, Dept Med & Oncol ISU, Mcallen, TX 78503 USA.
   [Alvi, Sahir Sultan] Univ Texas Rio Grande Valley, South Texas Ctr Excellence Canc Res, Sch Med, Mcallen, TX 78503 USA.
   [Khan, M. Salman] Era Univ, Dept Biotechnol, Lucknow, Uttar Pradesh, India.
C3 Integral University; Sanjay Gandhi Postgraduate Institute of Medical
   Sciences; University of Texas System; University of Texas Rio Grande
   Valley; University of Texas System; University of Texas Rio Grande
   Valley
RP Alvi, SS; Khan, MS (corresponding author), Integral Univ, Integral Informat & Res Ctr IIRC 5, Dept Biosci, Clin Biochem & Nat Prod Res Lab, Lucknow, Uttar Pradesh, India.; Alvi, SS (corresponding author), Univ Texas Rio Grande Valley, Sch Med, Dept Med & Oncol ISU, Mcallen, TX 78503 USA.; Alvi, SS (corresponding author), Univ Texas Rio Grande Valley, South Texas Ctr Excellence Canc Res, Sch Med, Mcallen, TX 78503 USA.; Khan, MS (corresponding author), Era Univ, Dept Biotechnol, Lucknow, Uttar Pradesh, India.
EM sahir.alvi@utrgv.edu; contactskhan@gmail.com
RI Ahmad, Parvej/AAS-7196-2020
OI Ahmad, Parvej/0000-0002-3102-4369; Alvi, Sahir
   Sultan/0000-0002-5650-748X
FU Young Scientist Award, Department of Health Research (DHR), Ministry of
   Health & Family Welfare (MoHFW), Government of India
   [R.12014/13/2019-HR]
FX This study was supported by the Young Scientist Award, Department of
   Health Research (DHR), Ministry of Health & Family Welfare (MoHFW),
   Government of India, R.12014/13/2019-HR.
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NR 73
TC 2
Z9 2
U1 4
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0951-418X
EI 1099-1573
J9 PHYTOTHER RES
JI Phytother. Res.
PD 2024 SEP 3
PY 2024
DI 10.1002/ptr.8323
EA SEP 2024
PG 21
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA E6O1D
UT WOS:001304169000001
PM 39225240
OA Bronze
DA 2025-06-11
ER

PT J
AU Khan, RJ
   Gebreab, SY
   Sims, M
   Riestra, P
   Xu, RH
   Davis, SK
AF Khan, Rumana J.
   Gebreab, Samson Y.
   Sims, Mario
   Riestra, Pia
   Xu, Ruihua
   Davis, Sharon K.
TI Prevalence, associated factors and heritabilities of metabolic syndrome
   and its individual components in African Americans: the Jackson Heart
   Study
SO BMJ OPEN
LA English
DT Article
DE Metabolic Syndrome; African Americans; Heritability
ID CARDIOVASCULAR RISK; INSULIN-RESISTANCE; EUROPEAN-AMERICAN; CENTRAL
   OBESITY; SYNDROME TRAITS; PREDICTION; HOMOCYSTEINE; ADIPONECTIN;
   DEFINITION; GENETICS
AB Objective Both environmental and genetic factors play important roles in the development of metabolic syndrome (MetS). Studies about its associated factors and genetic contribution in African Americans (AA) are sparse. Our aim was to report the prevalence, associated factors and heritability estimates of MetS and its components in AA men and women.
   Participants and setting Data of this cross-sectional study come from a large community-based Jackson Heart Study (JHS). We analysed a total of 5227 participants, of whom 1636 from 281 families were part of a family study subset of JHS.
   Methods Participants were classified as having MetS according to the Adult Treatment Panel III criteria. Multiple logistic regression analysis was performed to isolate independently associated factors of MetS (n=5227). Heritability was estimated from the family study subset using variance component methods (n=1636).
   Results About 27% of men and 40% of women had MetS. For men, associated factors with having MetS were older age, lower physical activity, higher body mass index, and higher homocysteine and adiponectin levels (p<0.05 for all). For women, in addition to all these, lower education, current smoking and higher stress were also significant (p<0.05 for all). After adjusting for covariates, the heritability of MetS was 32% (p<0.001). Heritability ranged from 14 to 45% among its individual components. Relatively higher heritability was estimated for waist circumference (45%), high density lipoprotein-cholesterol (43%) and triglycerides (42%). Heritability of systolic blood pressure (BP), diastolic BP and fasting blood glucose was 16%, 15% and 14%, respectively.
   Conclusions Stress and low education were associated with having MetS in AA women, but not in men. Higher heritability estimates for lipids and waist circumference support the hypothesis of lipid metabolism playing a central role in the development of MetS and encourage additional efforts to identify the underlying susceptibility genes for this syndrome in AA.
C1 [Khan, Rumana J.; Gebreab, Samson Y.; Riestra, Pia; Xu, Ruihua; Davis, Sharon K.] NHGRI, Cardiovasc Sect, Cardiovasc & Inflammatory Dis Genom Branch, NIH, Bethesda, MD 20892 USA.
   [Sims, Mario] Univ Mississippi, Med Ctr, Dept Internal Med, Div Hypertens, Jackson, MS 39216 USA.
C3 National Institutes of Health (NIH) - USA; NIH National Human Genome
   Research Institute (NHGRI); University of Mississippi Medical Center;
   University of Mississippi
RP Khan, RJ (corresponding author), NHGRI, Cardiovasc Sect, Cardiovasc & Inflammatory Dis Genom Branch, NIH, Bethesda, MD 20892 USA.
EM rumana.khan@nih.gov
RI Xu, Rui-Hua/AAW-4766-2021
OI Xu, Rui-Hua/0000-0001-9771-8534
FU National Institutes of Health; National Heart, Lung, and Blood Institute
   [HHSN2682013000 46C, HHSN2682013000 47C, HHSN268201300048C,
   HHSN268201300049C, HHSN268201300050C]; National Institute on Minority
   Health and Health Disparities
FX This research was supported by the Intramural Research Program of the
   National Institutes of Health. The Jackson Heart Study is supported by
   contracts HHSN2682013000 46C, HHSN2682013000 47C, HHSN268201300048C,
   HHSN268201300049C, HHSN268201300050C from the National Heart, Lung, and
   Blood Institute and the National Institute on Minority Health and Health
   Disparities.
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NR 51
TC 37
Z9 40
U1 0
U2 8
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2044-6055
J9 BMJ OPEN
JI BMJ Open
PY 2015
VL 5
IS 10
AR e008675
DI 10.1136/bmjopen-2015-008675
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA CX1PH
UT WOS:000365467600068
PM 26525420
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU McCarty, MF
AF McCarty, Mark F.
TI Salsalate may have broad utility in the prevention and treatment of
   vascular disorders and the metabolic syndrome
SO MEDICAL HYPOTHESES
LA English
DT Article
ID NF-KAPPA-B; INDUCED INSULIN-RESISTANCE; ABDOMINAL AORTIC-ANEURYSMS;
   NONACETYLATED SALICYLATE; OXIDATIVE STRESS; PYRROLIDINE DITHIOCARBAMATE;
   DIABETIC-RETINOPATHY; ATRIAL-FIBRILLATION; SODIUM-SALICYLATE; NAD(P)H
   OXIDASE
AB In the high proportion of vascular disorders associated with excessive oxidative stress and production of pro-inflammatory cytokines, activation of NF-kappaB plays a key pathogenic role. Thus, there is considerable evidence that NF-kappaB is a mediator of atherogenesis, plaque destabilization, ischemia-reperfusion damage, cardiac remodeling, atrial fibrillation, and aneurysm formation and rupture; some studies suggest that it may also play a role in the microvascular complications of diabetes. IkappaB kinase-beta (IKKbeta) is the upstream kinase that appears to be primarily responsible for NF-kappaB activation in these disorders; moreover, chronic IKKbeta activation plays a prominent role in induction of insulin resistance in the metabolic syndrome. Salicylate inhibits IKKbeta in concentrations that are achievable with dose schedules traditionally used in treating rheumatoid arthritis (3-4.5 g daily); indeed, this is likely to be the mechanism responsible for salicylate's utility in this disorder. Salicylate, unlike aspirin, is only a very weak, reversible inhibitor of cyclooxygenase in clinical doses, and thus is not associated with the potentially dangerous side effects seen with NSAIDs; fully reversible ototoxicity, the dose-limiting side effect in salicylate therapy, can be avoided in most patients by dosage adjustment. Hence, it is proposed that salicylate may have practical utility in the prevention or management of a wide range of vascular disorders as well as of metabolic syndrome and diabetes; its efficacy in these regards would likely be complemented by effective antioxidant measures, which would lessen the stimulus to NF-kappaB activation while providing benefits independent of NF-kappaB activity. Salsalate, consisting of two salicylate molecules united by an ester bond, is a venerable drug that may be the best tolerated delivery vehicle for salicylate. Appropriate rodent studies should pave the way for clinical trials with salsalate in patients at vascular risk. (C) 2010 Elsevier Ltd. All rights reserved.
C1 NutriGuard Res, San Diego, CA 92024 USA.
RP McCarty, MF (corresponding author), NutriGuard Res, 1051 Hermes Ave,811 B Nahant Ct, San Diego, CA 92024 USA.
EM mccarty@pantox.com
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NR 111
TC 19
Z9 20
U1 0
U2 10
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0306-9877
EI 1532-2777
J9 MED HYPOTHESES
JI Med. Hypotheses
PD SEP
PY 2010
VL 75
IS 3
BP 276
EP 281
DI 10.1016/j.mehy.2009.12.027
PG 6
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 647IF
UT WOS:000281611100002
PM 20080359
DA 2025-06-11
ER

PT J
AU Lohse, B
   Nguyen, B
   Drees, BM
   Bailey-Davis, L
   Masters, KS
   Nicklas, JM
   Daniels, BT
   Ruder, EH
   Trabold, N
AF Lohse, Barbara
   Nguyen, Bong
   Drees, Betty M.
   Bailey-Davis, Lisa
   Masters, Kevin S.
   Nicklas, Jacinda M.
   Daniels, Bryce T.
   Ruder, Elizabeth H.
   Trabold, Nicole
TI Examination of eating competence in a geo-diverse sample with metabolic
   syndrome
SO APPETITE
LA English
DT Article
DE Eating behavior; Eating competence; Metabolic syndrome; Mindfulness;
   Quality-of-life; Waist circumference
ID BEHAVIORS; DIET; QUESTIONNAIRE; OVERWEIGHT; VALIDITY; PROGRAM; SUPPORT;
   QUALITY; IMPACT; FRUIT
AB Eating competence (EatC) is an intra-individual approach to eating attitudes and behaviors associated with greater well-being. EatC research has not included persons with confirmed metabolic syndrome (MetS). Therefore, EatC of persons with MetS was explored to identify unique associations and inform implementation of MetS lifestyle interventions using baseline data from a multisite, randomized trial of a 2-year lifestyle intervention with MetS. EatC, measured with the Satter Eating Competence Inventory 2.0 (ecSI 2.0 (TM)), was examined for relationships with bioclinical measures (e.g., blood pressure, lipids), medication use, BMI, waist circumference, fruit/vegetable intake, and psychosocial factors, (e.g., stress, mindfulness). Data were collected in person and video call by trained research personnel. EatC was examined as a continuous score and as a categorical variable with ecSI 2.0 (TM) scores >= 32 considered eating competent. Participants (n = 618) were predominantly female (76%), White (74%), college educated (60%). Mean age was 55.5 +/- 11 y. Mean ecSI 2.0 (TM) was 29.9 +/- 7.4 and 42% were eating competent. EatC was greater for males, persons who were older and food secure. Competent eaters (vs. non-eating competent) had lower waist circumference (112.7 +/- 12.5 cm vs.116.8 +/- 16.0 cm; P < 0.001) and BMI (35.0 +/- 6.1 vs. 37.5 +/- 7.3; P < 0.001). Serum triglycerides, HDL-cholesterol, fasting blood glucose, HbA1c, and blood pressure did not differ by EatC status. Compared to non-eating competent persons, competent eaters perceived less stress, were more mindful, indicated better physical function, and more habitual vegetable intake (all P < 0.001) and sensory awareness (P < 0.05). EatC in MetS paralleled the non-MetS profile. EatC was associated with a healthier psychosocial profile, waist circumference and BMI. Findings support further research to examine the mediational or moderating influence of EatC in the treatment of MetS.
C1 [Lohse, Barbara; Ruder, Elizabeth H.; Trabold, Nicole] Rochester Inst Technol, 180 Lomb Mem Dr, Rochester, NY 14623 USA.
   [Nguyen, Bong; Drees, Betty M.] Univ Missouri, Sch Med, 2411 Holmes St, Kansas City, MO 64108 USA.
   [Bailey-Davis, Lisa] Geisinger Hlth Syst, 100 N Acad Ave, Danville, PA 17822 USA.
   [Masters, Kevin S.; Nicklas, Jacinda M.] Univ Colorado Denver, 13001 E 17th Pl, Aurora, CO 80045 USA.
   [Daniels, Bryce T.] Rush Univ, Med Ctr, 1700 W Van Buren St,Suite 470, Chicago, IL 60612 USA.
   [Trabold, Nicole] Syracuse VA Med Ctr, Ctr Integrated Healthcare, Syracuse, NY 13210 USA.
C3 Rochester Institute of Technology; University of Missouri System;
   University of Missouri Kansas City; Geisinger Health System; University
   of Colorado System; University of Colorado Anschutz Medical Campus;
   Children's Hospital Colorado; Rush University; Syracuse University
RP Lohse, B (corresponding author), Rochester Inst Technol, 180 Lomb Mem Dr, Rochester, NY 14623 USA.
EM balihst@rit.edu; bong.nguyen@umkc.edu; dreesb@umkc.edu;
   ldbaileydavis@geisinger.edu; Kevin.Masters@ucdenver.edu;
   jacinda.nicklas@ucdenver.edu; Bryce_Daniels@rush.edu; ehrihst@rit.edu;
   nxtihst@rit.edu
RI Nguyen, Bong/LZH-0438-2025
FU William G. McGowan Charitable Fund; Wegmans School of Health and
   Nutrition at the Rochester Institute of Technology
FX This work was supported by a grant from the William G. McGowan
   Charitable Fund and by the Wegmans School of Health and Nutrition at the
   Rochester Institute of Technology.
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NR 63
TC 0
Z9 0
U1 0
U2 1
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 0195-6663
EI 1095-8304
J9 APPETITE
JI Appetite
PD AUG 1
PY 2024
VL 199
AR 107373
DI 10.1016/j.appet.2024.107373
EA MAY 2024
PG 12
WC Behavioral Sciences; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Behavioral Sciences; Nutrition & Dietetics
GA TQ2P5
UT WOS:001242662800001
PM 38677621
OA hybrid
DA 2025-06-11
ER

PT J
AU Bengmark, S
AF Bengmark, S
TI Acute and "chronic" phase reaction - a mother of disease
SO CLINICAL NUTRITION
LA English
DT Review
DE acute phase esponse; chronic phase response; metabolic syndrome;
   cellular membranes; endothelial cells; abdominal obesity; insulin
   resistance; growth hormones; free fatty acids; Alzheimer disease;
   Parkinson disease; neurodegenerative iseases; arteriosclerosis;
   coronary-vascular diseases; cancer; breast cancer; colorectal cancer;
   prostatic cancer; diabetes; cirrhosis; fatty liver; gallbladder disease;
   chronic renal disease; chroncic locomotor disease; gout; rheumatoid
   arthritis; Crohn's disease; ulcerative disease; inflammatory bowel
   disease; irritable bowel syndrome; polycystic ovary syndrome
ID FREE FATTY-ACID; CORONARY-HEART-DISEASE; PLASMINOGEN-ACTIVATOR
   INHIBITOR-1; INSULIN-RESISTANCE; CELL-MEMBRANE; ENDOTHELIAL DYSFUNCTION;
   HOMOCYSTEINE LEVELS; DIABETES-MELLITUS; ENERGY-METABOLISM; LIVER
   STEATOSIS
AB The world is increasingly threatened by a global epidemy of chronic diseases. Almost half of the global morbidity and almost two thirds of global mortality is due to these diseases-approximately 35 million die each year from chronic diseases. And they continue to increase. Increasing evidence suggest that these diseases are associated with lifestyle, stress, lack of physical exercise, over-consumption of calorie-condensed foods rich in saturated fat, sugar and starch, but also under-consumption of antioxidant-rich fruits and vegetables. As a result the function of the innate immune system is severe impaired. This review discusses the changes induced in response to mental and physical stress and their association with the subsequent development of metabolic syndrome, and its association with various chronic diseases. The endothelial cells and their function appears to be of great importance, and the function of their cellular membranes of special importance to the function of the underlying cells; their ability to obtain nutrients and antioxidants and to eliminate waste products. The abdominal adipocytes seen to play a key role, as they have the ability to in stressful situations release much of proinflammatory cytokines, PAI-1 and free fatty acids compared to elsewhere in the body. The load on the liver of these various substances in often of greater magnitude than the liver can handle. Some of the most common chronic diseases and their potential association with acute and "chronic" phase response, and with metabolic syndrome are discussed separately. The need for studies with lifestyle modifications is especially emphasized. (C) 2004 Elsevier Ltd. All rights reserved.
C1 UCL, Dept Surg & Liver Inst, London, England.
C3 University of London; University College London
RP UCL, Dept Surg & Liver Inst, London, England.
EM S.bengmark@ucl.ac.uk
OI Bengmark, Stig/0000-0003-1809-8889
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NR 103
TC 47
Z9 50
U1 0
U2 10
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0261-5614
EI 1532-1983
J9 CLIN NUTR
JI Clin. Nutr.
PD DEC
PY 2004
VL 23
IS 6
BP 1256
EP 1266
DI 10.1016/j.clnu.2004.07.016
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 879NJ
UT WOS:000225724200002
PM 15556248
DA 2025-06-11
ER

PT J
AU Pan, Y
   Kong, LD
AF Pan, Ying
   Kong, Ling-Dong
TI High fructose diet-induced metabolic syndrome: Pathophysiological
   mechanism and treatment by traditional Chinese medicine
SO PHARMACOLOGICAL RESEARCH
LA English
DT Review
DE Traditional Chinese medicine (TCM); Fructose; Metabolic syndrome (MetS)
ID FATTY LIVER-DISEASE; NLRP3 INFLAMMASOME ACTIVATION; INDUCED
   INSULIN-RESISTANCE; INDUCED HEPATIC STEATOSIS; NECROSIS-FACTOR-ALPHA;
   NF-KAPPA-B; TANG-KE-LI; URIC-ACID; OXIDATIVE STRESS; LIPID-ACCUMULATION
AB Fructose is a natural monosaccharide broadly used in modern society. Over the past few decades, epidemiological studies have demonstrated that high fructose intake is an etiological factor of metabolic syndrome (MetS). This review highlights research advances on fructose-induced MetS, especially the underlying pathophysiological mechanism as well as pharmacotherapy by traditional Chinese medicine (TCM), using the PubMed, Web of science, China National Knowledge Infrastructure, China Science and Technology Journal and Wanfang Data. This review focuses on de novo lipogenesis (DNL) and uric acid (UA) production, two unique features of fructolysis different from glucose glycolysis. High level of DNL and UA production can result in insulin resistance, the key pathological event in developing MetS, mostly through oxidative stress and inflammation. Some other pathologies like the disturbance in brain and gut microbiota in the development of fructose-induced MetS in the past years, are also discussed. In management of MetS, TCM is an excellent representative in alternative and complementary medicine with a complete theory system and substantial herbal remedies. TCMs against MetS or MetS components, including Chinese patent medicines, TCM compound formulas, single TCM herbs and active compounds of TCM herbs, are reviewed on their effects and molecular mechanisms. TCMs with hypouricemic activity, which specially target fructose-induced MetS, are highlighted. And new technologies and strategies (such as high-throughput assay and systems biology) in this field are further discussed. In summary, fructose-induced MetS is a multifactorial disorder with the underlying complex mechanisms. Current clinical and pre-clinical evidence supports the potential of TCMs in management of MetS. Additionally, TCMs may show some advantages against complex MetS as their holistic feature through multiple target actions. However, further work is needed to confirm the effectivity and safety of TCMs by high-standard clinical trials, clarify the molecular mechanisms, and develop new anti-MetS drugs by development and application of optimized and feasible strategies and methods (C) 2018 Elsevier Ltd. All rights reserved.
C1 [Pan, Ying; Kong, Ling-Dong] Nanjing Univ, Sch Life Sci, State Key Lab Pharmaceut Biotechnol, Nanjing 210023, Jiangsu, Peoples R China.
C3 Nanjing University
RP Kong, LD (corresponding author), Nanjing Univ, Sch Life Sci, State Key Lab Pharmaceut Biotechnol, Nanjing 210023, Jiangsu, Peoples R China.
EM kongld@nju.edu.cn
FU National Natural Science Foundation of China [81730105]
FX This work was supported by Grant from National Natural Science
   Foundation of China (No. 81730105) to Ling-Dong Kong.
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NR 172
TC 55
Z9 58
U1 3
U2 77
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 1043-6618
J9 PHARMACOL RES
JI Pharmacol. Res.
PD APR
PY 2018
VL 130
BP 438
EP 450
DI 10.1016/j.phrs.2018.02.020
PG 13
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA GG9JN
UT WOS:000433016900038
PM 29471102
DA 2025-06-11
ER

PT J
AU Rosenbaum, S
   Stubbs, B
   Ward, PB
   Steel, Z
   Lederman, O
   Vancampfort, D
AF Rosenbaum, Simon
   Stubbs, Brendon
   Ward, Philip B.
   Steel, Zachary
   Lederman, Oscar
   Vancampfort, Davy
TI The prevalence and risk of metabolic syndrome and its components among
   people with posttraumatic stress disorder: a systematic review and
   meta-analysis
SO METABOLISM-CLINICAL AND EXPERIMENTAL
LA English
DT Review
DE PTSD; Metabolic syndrome; Glucose; Cardiovascular disease; Lipids
ID 3RD NATIONAL-HEALTH; US ADULTS; ABNORMALITIES; SCHIZOPHRENIA; MORTALITY;
   DISEASE; HEART; PTSD; ASSOCIATION; POPULATION
AB Objective. People with posttraumatic stress disorder (PTSD) have a higher mortality than the general population, mainly due to cardiovascular diseases (CVD). Metabolic syndrome (MetS) and its components are highly predictive of CVD. The aim of this meta-analysis was to describe pooled frequencies of MetS and its components in people with PTSD and to compare MetS prevalence in PTSD versus the general population.
   Method. Medline, PsycARTICLES, Embase and CINAHL were searched until 02/2015 for cross-sectional and baseline data of longitudinal studies in adults with PTSD. Two independent reviewers conducted the searches and extracted data. Random effects meta-analysis with a relative risk, subgroups and meta-regression analyses were employed.
   Results. Overall, 9 studies met the inclusion criteria including 9,673 individuals in midlife with PTSD and 6852 general population controls. The pooled MetS prevalence was 38.7% (95% CI = 32.1%-45.6%; Q = 52.1, p < 0.001; N = 9; n = 9,673; age range = 44-61 years). Abdominal obesity was observed in 49.3% (95% CI = 29.7%-69.0%), hyperglycemia in 36.1% (95% CI = 18.8%-55.6%), hypertriglyceridemia in 45.9% (95% CI = 12.2%-81.9%), low high density-lipoprotein-cholesterol in 46.4% (95% CI = 26.4%-67.0%) and hypertension in 76.9% (95% CI = 67.9%-84.8%). The MetS prevalence was consistently high across geographical regions, settings or populations (war veterans or not). Compared with matched general population controls, people with PTSD had an almost double increased risk for MetS (RR = 1.82; 95% CI = 1.72-1.92; p <0.001). Most analyses were not statistically heterogeneous.
   Conclusions. MetS is highly prevalent in people with PTSD. Routine screening and multidisciplinary management of medical and behavioral conditions is needed. Future research should focus on how cardio-metabolic outcomes are moderated by clinical and treatment characteristics and genetic factors. (C) 2015 Elsevier Inc. All rights reserved.
C1 [Rosenbaum, Simon; Ward, Philip B.; Steel, Zachary; Lederman, Oscar] Univ New S Wales, Sch Psychiat, Sydney, NSW, Australia.
   [Stubbs, Brendon] Univ Greenwich, Sch Hlth & Social Care, London SE18 6PF, England.
   [Vancampfort, Davy] KU Leuven Univ Leuven, UPC KU Leuven, Dept Neurosci, B-3070 Kortenberg, Belgium.
   [Vancampfort, Davy] KU Leuven Univ Leuven, Dept Rehabil Sci, Leuven, Belgium.
C3 University of New South Wales Sydney; University of Greenwich; KU
   Leuven; KU Leuven
RP Vancampfort, D (corresponding author), KU Leuven Univ Leuven, UPC KU Leuven, Dept Neurosci, Campus Kortenberg,Leuvensesteenweg 517, B-3070 Kortenberg, Belgium.
EM davy.vancampfort@uc-kortenberg.be
RI Vancampfort, Davy/AAD-1987-2019; Stubbs, Brendon/X-1904-2018; Rosenbaum,
   Simon/Y-3241-2019; Steel, Zachary/MEQ-2709-2025; Ward,
   Philip/JCE-6293-2023; Stubbs, Brendon/C-5696-2015
OI Ward, Philip/0000-0002-5779-7722; Rosenbaum, Simon/0000-0002-8984-4941;
   Stubbs, Brendon/0000-0001-7387-3791; Berle, David/0000-0002-4861-2220;
   Lederman, Oscar/0000-0002-0321-5723; Steel, Zachary/0000-0002-5048-2920
FU Research Foundation-Flanders (FWO-Vlaanderen)
FX Dr. Vancampfort has received grant support from the Research
   Foundation-Flanders (FWO-Vlaanderen). The other authors have no
   disclosures to report. The current work was not funded.
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NR 56
TC 172
Z9 183
U1 0
U2 22
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0026-0495
EI 1532-8600
J9 METABOLISM
JI Metab.-Clin. Exp.
PD AUG
PY 2015
VL 64
IS 8
BP 926
EP 933
DI 10.1016/j.metabol.2015.04.009
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA CK7HB
UT WOS:000356402300009
PM 25982700
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Dai, WY
   Wagh, SA
   Chettiar, S
   Zhou, GD
   Roy, R
   Qiao, XY
   Visich, PS
   Hoffman, EP
AF Dai, Weiying
   Wagh, Swanand A.
   Chettiar, Steffi
   Zhou, Grace D.
   Roy, Runia
   Qiao, Xingye
   Visich, Paul S.
   Hoffman, Eric P.
TI Blunted circadian cortisol in children is associated with poor
   cardiovascular health and may reflect circadian misalignment
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE Circadian rhythm; Blood pressure; Metabolic syndrome; Cortisol
ID EARLY SOCIAL DEPRIVATION; DISEASE RISK-FACTORS; BLOOD-PRESSURE;
   METABOLIC SYNDROME; SERUM CORTISOL; LTC RELATION; OBESITY; STRESS;
   INFLAMMATION; ADOLESCENTS
AB Objectives: Circadian cues in children (sunlight, exercise, diet patterns) may be associated with health outcomes. The primary objective was to assess associations of daily cortisol fluctuations (morning, night) with cardiovascular health outcomes. A secondary objective was to determine if 1-year longitudinal changes in circadian cortisol levels are associated with longitudinal changes in health outcomes.
   Study design: The Cardiovascular Health Intervention Program (CHIP) was a cross-sectional and longitudinal study of cardiovascular risk profiles in public elementary school children in Southern Maine. Participants were 689 students in 4th grade (baseline; age = 9.20 +/- 0.41 years), and 647 students in 5th grade (age = 10.53 +/- 0.52 years). Longitudinal data (4th and 5th grade) was available for 347 participants. Clinical outcomes were blood pressure, hip/waist ratios, body mass index, percent fat. Laboratory measures were fasting glucose, lipids, and salivary cortisol measures (morning and evening).
   Results: Lower first-in-morning diurnal cortisol levels were associated with increased blood pressure beta -0.23 +/- 0.05; p < 0.001), increased body fat (beta -0.22 +/- 0.05; p < 0.001), and poor lipid profiles (beta -0.15 +/- 0.07; p < 0.05). Inclusion of night cortisol in the model (stress-related) improved associations of the model with bodyfat composition (morning beta -0.27 +/- 0.05; p < 0.001; night beta +0.16 +/- 0.06; p < 0.01). Adjustments for potential confounding variables improved associations of morning cortisol with lipids (beta -0.19 +/- 0.07; p < 0.01). Longitudinal analysis showed that lower morning diurnal cortisol in 4th grade was associated with increases in blood pressure a year later (beta -0.18 +/- 0.08; p = 0.017) after adjusting for confounding variables.
   Conclusion: Data presented suggest adding circadian misalignment (lower amplitude of first-in-morning cortisol) to existing models of metabolic syndrome in children. Further, circadian misalignment may be a factor contributing to high blood pressure.
C1 [Dai, Weiying; Wagh, Swanand A.; Chettiar, Steffi] SUNY Binghamton, Dept Comp Sci, Binghamton, NY 13902 USA.
   [Zhou, Grace D.; Roy, Runia; Hoffman, Eric P.] SUNY Binghamton, Dept Pharmaceut Sci, Binghamton, NY 13902 USA.
   [Roy, Runia] SUNY Binghamton, Dept Biomed Engn, Binghamton, NY 13902 USA.
   [Qiao, Xingye] SUNY Binghamton, Dept Math Sci, Binghamton, NY 13902 USA.
   [Visich, Paul S.] Univ New England, Exercise & Sport Performance Dept, Biddeford, ME USA.
C3 State University of New York (SUNY) System; Binghamton University, SUNY;
   State University of New York (SUNY) System; Binghamton University, SUNY;
   State University of New York (SUNY) System; Binghamton University, SUNY;
   State University of New York (SUNY) System; Binghamton University, SUNY;
   University of New England - Maine
RP Hoffman, EP (corresponding author), SUNY Binghamton, Dept Pharmaceut Sci, Binghamton, NY 13902 USA.
EM ehoffman@binghamton.edu
RI Zhou, Grace/KBA-5091-2024; Qiao, Xingye/P-6321-2019; Hoffman,
   Eric/KYP-6390-2024
OI Qiao, Xingye/0000-0003-0937-9822
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NR 47
TC 8
Z9 8
U1 2
U2 11
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
EI 1873-3360
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD JUL
PY 2021
VL 129
AR 105252
DI 10.1016/j.psyneuen.2021.105252
EA MAY 2021
PG 9
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA SR9ZR
UT WOS:000661403000013
PM 34049197
OA hybrid
DA 2025-06-11
ER

PT J
AU Cheng, H
   Zhou, JY
   Sun, YT
   Zhan, QP
   Zhang, DF
AF Cheng, Hao
   Zhou, Jingyang
   Sun, Yutong
   Zhan, Qipeng
   Zhang, Dunfang
TI High fructose diet: A risk factor for immune system dysregulation
SO HUMAN IMMUNOLOGY
LA English
DT Review
DE Fructose; Inflammation; Autoimmunity; Cancer; Microbiota
ID TOLL-LIKE RECEPTOR; INTESTINAL BARRIER FUNCTION; CHAIN FATTY-ACIDS;
   OXIDATIVE STRESS; URIC-ACID; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   HEPATIC STEATOSIS; LIVER; INFLAMMATION
AB Excessive intake of sweets is a predisposing factor for metabolic disorders, and fructose, as one of the major dietary sugars in the diet, has been shown to be a major cause of obesity, diabetes, and metabolic syndrome. These disorders are usually associated with immune dysfunction. Therefore, exploring the effects of a high fructose diet on the immune system may provide insight into the underlying mechanisms of these diseases. We synthesized the available evidence to suggest that excessive fructose intake disrupts the body's immune homeostasis by promoting immune cell metabolic rearrangements, alterations in gut microbial community structure, and intestinal barrier permeability. Indeed, not only does fructose itself affect immune system homeostasis, but its metabolites also have a profound influence. The metabolites from fructolysis are mainly produced in the small intestine and liver and subsequently enter the systemic circulation. Elevated levels of fructose metabolites, such as uric acid, FFAs, and lactate, are closely associated with oxidative stress and local tissue and organ inflammatory responses. In this review, we will focus on the link between fructose and inflammatory responses. In the meanwhile, we will also briefly summarize the studies of cancer development and immune escape mediated by fructose, as it might be beneficial for cancer immunotherapy. (c) 2022 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.
C1 [Zhang, Dunfang] Sichuan Univ, State Key Lab Biotherapy, Dept Biotherapy, Chengdu, Sichuan, Peoples R China.
   Sichuan Univ, West China Hosp, Canc Ctr, Chengdu, Sichuan, Peoples R China.
C3 Sichuan University; Sichuan University
RP Zhang, DF (corresponding author), Sichuan Univ, State Key Lab Biotherapy, Dept Biotherapy, Chengdu, Sichuan, Peoples R China.
EM izdf@163.com
RI Zhou, Jingyang/AAO-1184-2021
OI Zhang, Dunfang/0000-0001-7545-9930; Zhan, Qipeng/0009-0008-8510-6758
FU National Natural Science Foundation of China [82171829]; Key Project of
   the Science and Technology Department of Sichuan Province [2022YFH0100];
   1<SUP>.</SUP>3 5 Project for Disciplines of Excellence, West China
   Hospital, Sichuan University [ZYYC21012]; Fundamental Research Funds for
   the Central Universities, China [20822041E4084]
FX This work was supported by the National Natural Science Foundation of
   China (NO. 82171829), the Key Project of the Science and Technology
   Department of Sichuan Province (NO. 2022YFH0100), the
   1<SUP>.</SUP>3<SUP>.</SUP>5 Project for Disciplines of Excellence, West
   China Hospital, Sichuan University (NO. ZYYC21012), and the Fundamental
   Research Funds for the Central Universities, China (20822041E4084). DZ
   sincerely wants to commemorate Dr. SangA Park, who passed away suddenly
   on January 22, 2018.
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NR 126
TC 19
Z9 21
U1 6
U2 35
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0198-8859
EI 1879-1166
J9 HUM IMMUNOL
JI Hum. Immunol.
PD JUN
PY 2022
VL 83
IS 6
BP 538
EP 546
DI 10.1016/j.humimm.2022.03.007
EA MAY 2022
PG 9
WC Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology
GA 1T5TW
UT WOS:000804791600010
PM 35414462
DA 2025-06-11
ER

PT J
AU Martínez, AD
   Ruelas, L
   Granger, DA
AF Martinez, Airin D.
   Ruelas, Lillian
   Granger, Douglas A.
TI Household fear of deportation in Mexican-origin families: Relation to
   body mass index percentiles and salivary uric acid
SO AMERICAN JOURNAL OF HUMAN BIOLOGY
LA English
DT Article
ID NUTRITION EXAMINATION SURVEY; 3RD NATIONAL-HEALTH; METABOLIC SYNDROME;
   FOOD INSECURITY; UNITED-STATES; CHOLESTEROL VARIABILITY; IMMIGRATION
   POLICIES; PSYCHOSOCIAL STRESS; LATINO IMMIGRANTS; PUBLIC-HEALTH
AB ObjectiveFear of deportation (FOD) is a prevalent concern among mixed-status families. Yet, our understanding of how FOD shapes human health and development is in its infancy. To begin to address this knowledge gap, we examined the relationship between household FOD, body mass index (BMI) percentiles and salivary uric acid (sUA), a biomarker related to oxidative stress/hypertension/metabolic syndrome, among 111 individuals living in Mexican-origin families.
   MethodsParticipants were 65 children (2 months-17 years, 49% female) and 46 adults (20-58 years, 71% female) living in 30 Mexican-origin families with at least one immigrant parent in Phoenix, AZ. We recruited families using cluster probability sampling of 30 randomly selected census tracts with a high proportion of Hispanic/Latino immigrants. The head of household completed a survey containing demographic, FOD, and psychosocial measures. All family members provided saliva (later assayed for sUA) and anthropometric measures. Relationships between household FOD, BMI percentile, and sUA levels were estimated using multilevel models.
   ResultsHigher levels of household FOD were associated with lower BMI percentiles and lower sUA levels between families, after controlling for social support and socioeconomic proxies.
   ConclusionKey features of the social ecology in which mixed-status families are embedded are associated with individual differences in biological processes linked to increased risk for chronic disease.
C1 [Martinez, Airin D.; Ruelas, Lillian] Arizona State Univ, Sch Transborder Studies, Tempe, AZ USA.
   [Martinez, Airin D.] Yale Univ, Ethn Race & Migrat Program & Amer Studies, New Haven, CT USA.
   [Granger, Douglas A.] Univ Calif Irvine, Inst Interdisciplinary Salivary Biosci Res, Irvine, CA USA.
   [Granger, Douglas A.] Johns Hopkins Univ, Sch Med, Sch Nursing, Baltimore, MD USA.
   [Granger, Douglas A.] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Baltimore, MD USA.
   [Granger, Douglas A.] Univ Nebraska, Saliva Biosci Lab, Lincoln, NE USA.
   [Granger, Douglas A.] Univ Nebraska, Dept Psychol, Lincoln, NE 68588 USA.
C3 Arizona State University; Arizona State University-Tempe; Yale
   University; University of California System; University of California
   Irvine; Johns Hopkins University; Johns Hopkins University; Johns
   Hopkins Bloomberg School of Public Health; University of Nebraska
   System; University of Nebraska Lincoln; University of Nebraska System;
   University of Nebraska Lincoln
RP Martínez, AD (corresponding author), Arizona State Univ, Sch Transborder Studies, Coll Liberal Arts & Sci, Tempe, AZ 85782 USA.
EM admarti1@mainex1.asu.edu
FU ASU College of Liberal Arts and Sciences Seed Funding Mechanism; Program
   for Transborder Communities seed grant
FX This project received funding from the ASU College of Liberal Arts and
   Sciences Seed Funding Mechanism and the Program for Transborder
   Communities seed grant.
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NR 80
TC 20
Z9 20
U1 1
U2 22
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1042-0533
EI 1520-6300
J9 AM J HUM BIOL
JI Am. J. Hum. Biol.
PD NOV-DEC
PY 2017
VL 29
IS 6
AR e23044
DI 10.1002/ajhb.23044
PG 14
WC Anthropology; Biology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Anthropology; Life Sciences & Biomedicine - Other Topics
GA FM6VO
UT WOS:000415199300014
PM 28726338
OA Green Submitted, Green Accepted
DA 2025-06-11
ER

PT J
AU Johnson, RJ
   Lanaspa, MA
   Sanchez-Lozada, LG
   Tolan, D
   Nakagawa, T
   Ishimoto, T
   Andres-Hernando, A
   Rodriguez-Iturbe, B
   Stenvinkel, P
AF Johnson, Richard J.
   Lanaspa, Miguel A.
   Sanchez-Lozada, L. Gabriela
   Tolan, Dean
   Nakagawa, Takahiko
   Ishimoto, Takuji
   Andres-Hernando, Ana
   Rodriguez-Iturbe, Bernardo
   Stenvinkel, Peter
TI The fructose survival hypothesis for obesity
SO PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
LA English
DT Review
DE obesity; fructose; metabolic syndrome; sugar; diabetes; uric acid
ID URIC-ACID; METABOLIC SYNDROME; MEAT INTAKE; GLOMERULAR HYPERTENSION;
   OXIDATIVE STRESS; DIETARY FRUCTOSE; FATTY LIVER; MITOCHONDRIAL
   DYSFUNCTION; DIABETES-MELLITUS; ENERGY-METABOLISM
AB The fructose survival hypothesis proposes that obesity and metabolic disorders may have developed from over-stimulation of an evolutionary-based biologic response (survival switch) that aims to protect animals in advance of crisis. The response is characterized by hunger, thirst, foraging, weight gain, fat accumulation, insulin resistance, systemic inflammation and increased blood pressure. The process is initiated by the ingestion of fructose or by stimulating endogenous fructose production via the polyol pathway. Unlike other nutrients, fructose reduces the active energy (adenosine triphosphate) in the cell, while blocking its regeneration from fat stores. This is mediated by intracellular uric acid, mitochondrial oxidative stress, the inhibition of AMP kinase and stimulation of vasopressin. Mitochondrial oxidative phosphorylation is suppressed, and glycolysis stimulated. While this response is aimed to be modest and short-lived, the response in humans is exaggerated due to gain of 'thrifty genes' coupled with a western diet rich in foods that contain or generate fructose. We propose excessive fructose metabolism not only explains obesity but the epidemics of diabetes, hypertension, non-alcoholic fatty liver disease, obesity-associated cancers, vascular and Alzheimer's dementia, and even ageing. Moreover, the hypothesis unites current hypotheses on obesity. Reducing activation and/or blocking this pathway and stimulating mitochondrial regeneration may benefit health-span.This article is part of a discussion meeting issue 'Causes of obesity: theories, conjectures and evidence (Part I)'.
C1 [Johnson, Richard J.; Lanaspa, Miguel A.; Andres-Hernando, Ana] Univ Colorado, Anschutz Med Ctr, Dept Med, Aurora, CO 80016 USA.
   [Sanchez-Lozada, L. Gabriela] Inst Nacl Cardiol Ignacio Chavez, Dept Cardiorenal Physiopathol, Mexico City 14080, Mexico.
   [Tolan, Dean] Boston Univ, Biol Dept, Boston, MA 02215 USA.
   [Nakagawa, Takahiko] Rakuwakai Otowa Hosp, Dept Nephrol, Kyoto 6078062, Japan.
   [Ishimoto, Takuji] Aichi Med Univ, Dept Nephrol & Rheumatol, Nagakute, Aichi 4801103, Japan.
   [Rodriguez-Iturbe, Bernardo] Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Nephrol & Mineral Metab, Mexico City 14080, Mexico.
   [Stenvinkel, Peter] Karolinska Inst, Dept Renal Med, S-17177 Stockholm, Sweden.
C3 University of Colorado System; University of Colorado Anschutz Medical
   Campus; National Institute of Cardiology - Mexico; Boston University;
   Aichi Medical University; Instituto Nacional de Ciencias Medicas y
   Nutricion Salvador Zubiran - Mexico; Karolinska Institutet
RP Johnson, RJ (corresponding author), Univ Colorado, Anschutz Med Ctr, Dept Med, Aurora, CO 80016 USA.
EM richard.johnson@cuanschutz.edu
RI Sanchez-Lozada, Laura/AAS-2104-2021; Rodriguez-Iturbe,
   Bernardo/KFX-2910-2024; Lanaspa, Miguel/AAO-4971-2020; Ishimoto,
   Takuji/M-4873-2014
OI Tolan, Dean/0000-0002-0598-7241; Andres-Hernando,
   Ana/0000-0002-0676-0188; Johnson, Richard/0000-0003-3312-8193
FU NIH [R01 DK121496, U01 AA027997]
FX Support for this study comes from NIH grants R01 DK121496 (R.J.J. and
   M.A.L.) and U01 AA027997 (R.J.J.).
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NR 209
TC 24
Z9 25
U1 2
U2 18
PU ROYAL SOC
PI LONDON
PA 6-9 CARLTON HOUSE TERRACE, LONDON SW1Y 5AG, ENGLAND
SN 0962-8436
EI 1471-2970
J9 PHILOS T R SOC B
JI Philos. Trans. R. Soc. B-Biol. Sci.
PD SEP 11
PY 2023
VL 378
IS 1885
AR 20220230
DI 10.1098/rstb.2022.0230
PG 16
WC Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics
GA N1JE3
UT WOS:001034651600009
PM 37482773
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Maneesai, P
   Wattanathorn, J
   Potue, P
   Khamseekaew, J
   Rattanakanokchai, S
   Thukham-Mee, W
   Muchimapura, S
   Pakdeechote, P
AF Maneesai, Putcharawipa
   Wattanathorn, Jintanaporn
   Potue, Prapassorn
   Khamseekaew, Juthamas
   Rattanakanokchai, Siwayu
   Thukham-Mee, Wipawee
   Muchimapura, Supaporn
   Pakdeechote, Poungrat
TI Cardiovascular complications are resolved by tuna protein hydrolysate
   supplementation in rats fed with a high-fat diet
SO SCIENTIFIC REPORTS
LA English
DT Article
ID NF-KAPPA-B; ANGIOTENSIN-II; METABOLIC SYNDROME; CARDIAC-HYPERTROPHY;
   NADPH OXIDASE; ASIATIC ACID; INFLAMMATION; ANTIOXIDANT; METFORMIN;
   EXPRESSION
AB This study is aimed to investigate whether tuna protein hydrolysate (TPH) supplementation could alleviate cardiovascular complications induced by a high-fat diet (HFD) in rats. Rats were fed a HFD for 16 weeks and given TPH (100 mg/kg, 300 mg/kg, or 500 mg/kg) or metformin (100 mg/kg) (n = 8) for the last four weeks. TPH had the following effects: resolved their impaired glucose tolerance, hyperglycemia, dyslipidemia, obesity, and hypertension (p < 0.05); alleviated left ventricular dysfunction and hypertrophy (p < 0.05), and vascular dysfunction and hypertrophy (p < 0.05); adipocyte hypertrophy; increases in circulating leptin and tumor necrosis factor (TNF-& alpha;) were mitigated (p < 0.05); increased renin-angiotensin system (RAS), oxidative stress, and decreased nitric oxide metabolites were modulated (p < 0.05). TPH restored the expression of angiotensin II receptor type 1 (AT1R)/NADPH oxidase 2 (NOX2), endothelial nitric oxide synthase (eNOS), nuclear factor erythroid 2-related factor (Nrf2)/heme oxygenase-1 (HO-1), and peroxisome proliferator-activated receptor & gamma; (PPAR & gamma;)/the nuclear factor kappa B (NF-& kappa;B) protein in cardiovascular tissue (p < 0.05). In metabolic syndrome (MS) rats, metformin and TPH had comparable effects. In conclusion, TPH alleviated cardiovascular complications related to MS. It suppressed RAS, oxidative stress, and inflammation that were associated with modulation of AT1R/NOX2, eNOS, Nrf2/HO-1, and PPAR & gamma;/NF-& kappa;B expression.
C1 [Maneesai, Putcharawipa; Wattanathorn, Jintanaporn; Potue, Prapassorn; Khamseekaew, Juthamas; Thukham-Mee, Wipawee; Muchimapura, Supaporn; Pakdeechote, Poungrat] Khon Kaen Univ, Fac Med, Dept Physiol, Khon Kaen 40002, Thailand.
   [Wattanathorn, Jintanaporn; Thukham-Mee, Wipawee; Muchimapura, Supaporn; Pakdeechote, Poungrat] Khon Kaen Univ, Res Inst Human High Performance & Hlth Promot, Khon Kaen 40002, Thailand.
   [Rattanakanokchai, Siwayu] Khon Kaen Univ, Fac Vet Med, Khon Kaen 40002, Thailand.
C3 Khon Kaen University; Khon Kaen University; Khon Kaen University
RP Pakdeechote, P (corresponding author), Khon Kaen Univ, Fac Med, Dept Physiol, Khon Kaen 40002, Thailand.; Pakdeechote, P (corresponding author), Khon Kaen Univ, Res Inst Human High Performance & Hlth Promot, Khon Kaen 40002, Thailand.
EM ppoung@kku.ac.th
RI Maneesai, Putcharawipa/AAK-4258-2021
OI Maneesai, Putcharawipa/0000-0003-0889-6211
FU Program Management Unit Competitiveness (PMUC), Thailand
FX This study was supported by the Program Management Unit Competitiveness
   (PMUC), Thailand. We would like to thank Thai Union Group PCL for
   providing tuna protein hydrolysate and its composition data.
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NR 65
TC 5
Z9 5
U1 1
U2 8
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD JUL 28
PY 2023
VL 13
IS 1
AR 12280
DI 10.1038/s41598-023-39538-z
PG 17
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA O1OR5
UT WOS:001041587900034
PM 37507421
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Rauchová, H
   Neprasová, B
   Maletínská, L
   Kunes, J
AF Rauchova, Hana
   Neprasova, Barbora
   Maletinska, Lenka
   Kunes, Jaroslav
TI Glutathione Levels and Lipid Oxidative Damage in Selected Organs of
   Obese Koletsky and Lean Spontaneously Hypertensive Rats
SO PHYSIOLOGICAL RESEARCH
LA English
DT Article
DE Thiobarbituric acid-reactive substances; Heart; Renal cortex; Renal
   medulla; Liver
ID SEX-DIFFERENCES; BLOOD-PRESSURE; RECEPTOR; GLUCOSE
AB Koletsky rats, the genetically obese strain of spontaneously hypertensive rats (SHROB), are the well-accepted animal model of human metabolic syndrome. They are characterized by early onset obesity, spontaneous hypertension, hyperinsulinemia, hyperlipidemia, proteinuria and shortened life-span. One of the factors in the pathogenesis of metabolic syndrome is oxidative stress. The aim of the present study was to compare two parameters related to oxidative stress: the levels of the main intracellular antioxidant, reduced glutathione as well as the indirect indicator of lipid peroxidation damage, thiobarbituric acid-reactive substances (TBARS) in heart, renal cortex and medulla and liver in male lean spontaneously hypertensive rats (SHR) and obese Koletsky rats. We did not find any significant differences in these markers in heart and kidneys. However, we found significantly lower glutathione level in Koletsky rat liver compared with SHR (5.03 +/- 0.23 vs. 5.83 +/- 0.14 mu mol/g tissue, respectively). On the contrary, we observed significantly higher TBARS levels in Koletsky rat liver compared with SHR (28.56 +/- 2.15 vs. 21.83 +/- 1.60 nmol/mg protein, respectively). We conclude that the liver is the most sensitive tissue to oxidative damage with the significantly decreased concentration of glutathione and the significantly increased concentration of TBARS in obese Koletsky rats in comparison with lean control SHR.
C1 [Rauchova, Hana; Kunes, Jaroslav] Czech Acad Sci, Inst Physiol, Lab Expt Hypertens, Videnska 1083, CZ-14220 Prague 4, Czech Republic.
   [Neprasova, Barbora; Maletinska, Lenka; Kunes, Jaroslav] Czech Acad Sci, Inst Organ Chem & Biochem, Prague, Czech Republic.
C3 Czech Academy of Sciences; Institute of Physiology of the Czech Academy
   of Sciences; Czech Academy of Sciences; Institute of Organic Chemistry &
   Biochemistry of the Czech Academy of Sciences
RP Rauchová, H (corresponding author), Czech Acad Sci, Inst Physiol, Lab Expt Hypertens, Videnska 1083, CZ-14220 Prague 4, Czech Republic.
EM Hana.Rauchova@fgu.cas.cz
RI Kunes, Jaroslav/B-7079-2012; Rauchova, Hana/B-8288-2012
OI Rauchova, Hana/0000-0002-5807-3662
FU Institute of Physiology , Czech Academy of Sciences [RV0 67985823];
   Institute of Organic Chemistry and Biochemistry , Czech Academy of
   Sciences [RV0 61388963]; Project of National Institute for Research of
   Metabolic and Cardiovascular Diseases (Programme EXCELES) - European
   Union - Next Generation EU [LX22NPO5104]
FX This study was supported by the Institute of Physiology (grant number:
   RV0 67985823) and Institute of Organic Chemistry and Biochemistry (grant
   number: RV0 61388963) , Czech Academy of Sciences and the project of
   National Institute for Research of Metabolic and Cardiovascular Diseases
   (Programme EXCELES, ID Project No. LX22NPO5104) - Funded by the European
   Union - Next Generation EU.
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NR 17
TC 0
Z9 0
U1 0
U2 1
PU ACAD SCIENCES CZECH REPUBLIC, INST PHYSIOLOGY
PI PRAGUE 4
PA VIDENSKA 1083, PRAGUE 4 142 20, CZECH REPUBLIC
SN 0862-8408
EI 1802-9973
J9 PHYSIOL RES
JI Physiol. Res.
PD JUN
PY 2024
VL 73
IS 3
BP 481
EP 484
DI 10.33549/physiolres.935319
PG 4
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA YK0V9
UT WOS:001268274800014
PM 39027962
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Barrea, L
   Pugliese, G
   Frias-Toral, E
   El Ghoche, M
   Castellucci, B
   Chapela, SP
   Carignano, MD
   Laudisio, D
   Savastano, S
   Colao, A
   Muscogiuri, G
AF Barrea, Luigi
   Pugliese, Gabriella
   Frias-Toral, Evelyn
   El Ghoche, Marwan
   Castellucci, Bianca
   Pablo Chapela, Sebastian
   de los Angeles Carignano, Maria
   Laudisio, Daniela
   Savastano, Silvia
   Colao, Annamaria
   Muscogiuri, Giovanna
TI Coffee consumption, health benefits and side effects: a narrative review
   and update for dietitians and nutritionists
SO CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
LA English
DT Review
DE Coffee; caffeine; obesity; metabolic syndrome; nutritionist
ID POLYCYCLIC AROMATIC-HYDROCARBONS; DOSE-RESPONSE METAANALYSIS; HEPATIC
   LIPID-METABOLISM; INDUCED OXIDATIVE STRESS; CHLOROGENIC ACID; TEA
   CONSUMPTION; GREEN COFFEE; GEOGRAPHICAL ORIGIN; DIABETES-MELLITUS;
   GLUCOSE-TOLERANCE
AB Coffee is one of the most popular beverages worldwide; however, its impact on health outcomes and adverse effects is not fully understood. The current review aims to establish an update about the benefits of coffee consumption on health outcomes highlighting its side effects, and finally coming up with an attempt to provide some recommendations on its doses. A literature review using the PubMed/Medline database was carried out and the data were summarized by applying a narrative approach using the available evidence based on the literature. The main findings were the following: first, coffee may contribute to the prevention of inflammatory and oxidative stress-related diseases, such as obesity, metabolic syndrome and type 2 diabetes; second, coffee consumption seems to be associated with a lower incidence of several types of cancer and with a reduction in the risk of all-cause mortality; finally, the consumption of up to 400 mg/day (1-4 cups per day) of caffeine is safe. However, the time gap between coffee consumption and some drugs should be taken into account in order to avoid interaction. However, most of the data were based on cross-sectional or/and observational studies highlighting an association of coffee intake and health outcomes; thus, randomized controlled studies are needed in order to identify a causality link.
C1 [Barrea, Luigi] Univ Telemat Pegaso, Dipartimento Sci Umanist, Via Porzio,Isola F2, I-80143 Naples, Italy.
   [Barrea, Luigi; Pugliese, Gabriella; Castellucci, Bianca; Laudisio, Daniela; Savastano, Silvia; Colao, Annamaria; Muscogiuri, Giovanna] Univ Med Sch Naples, Ctr Italiano Cura & Benessere Paziente Obesita CI, Dept Clin Med & Surg, Endocrinol Unit, Via Sergio Pansini 5, I-80131 Naples, Italy.
   [Pugliese, Gabriella; Laudisio, Daniela; Savastano, Silvia; Colao, Annamaria; Muscogiuri, Giovanna] Univ Naples Federico II, Unit Endocrinol, Dipartimento Med Clin & Chirurg, Med Sch Naples, Via Sergio Pansini 5, I-80131 Naples, Italy.
   [Frias-Toral, Evelyn] Univ Catolica Santiago Guayaquil, Sch Med, Guayaquil, Ecuador.
   [El Ghoche, Marwan] Beirut Arab Univ, Fac Hlth Sci, Dept Nutr & Dietet, POB 11-5020 Riad El Solh, Beirut 11072809, Lebanon.
   [Pablo Chapela, Sebastian] Univ Buenos Aires, Fac Med, Dept Bioquim Humana, Buenos Aires, DF, Argentina.
   [Pablo Chapela, Sebastian] Hosp Britan Buenos Aires, Dept Terapia Intens, Buenos Aires, DF, Argentina.
   [de los Angeles Carignano, Maria] Sanatorio Franchin, Intens Care Unit, Bartolome Mitre 3565, Buenos Aires, DF, Argentina.
   [Colao, Annamaria; Muscogiuri, Giovanna] Univ Federico II, Cattedra Unesco Educ Salute & Allo Sviluppo Soste, Naples, Italy.
C3 Pegaso Online University; University of Naples Federico II; Beirut Arab
   University; University of Buenos Aires; Hospital Britanico de Buenos
   Aires; University of Naples Federico II
RP Barrea, L (corresponding author), Univ Telemat Pegaso, Dipartimento Sci Umanist, Via Porzio,Isola F2, I-80143 Naples, Italy.; Barrea, L (corresponding author), Univ Med Sch Naples, Ctr Italiano Cura & Benessere Paziente Obesita CI, Dept Clin Med & Surg, Endocrinol Unit, Via Sergio Pansini 5, I-80131 Naples, Italy.
EM luigi.barrea@unipegaso.it
RI Colao, Annamaria/A-7671-2011; Barrea, Luigi/K-6551-2016; Frias-Toral,
   Evelyn/AAZ-7346-2020; Savastano, Silvia/K-6546-2016
OI Barrea, Luigi/0000-0001-9054-456X; Castellucci,
   Bianca/0000-0001-7297-7492; Frias-Toral, Evelyn/0000-0002-2228-0141; ,
   Gabriella/0000-0002-8127-1755; Chapela, Sebastian
   Pablo/0000-0002-8083-1714; El Ghoch, Marwan/0000-0003-4277-4752;
   Savastano, Silvia/0000-0002-3211-4307
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NR 208
TC 64
Z9 64
U1 3
U2 66
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1040-8398
EI 1549-7852
J9 CRIT REV FOOD SCI
JI Crit. Rev. Food Sci. Nutr.
PD APR 3
PY 2023
VL 63
IS 9
BP 1238
EP 1261
DI 10.1080/10408398.2021.1963207
EA AUG 2021
PG 24
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA D4AH4
UT WOS:000690826100001
PM 34455881
DA 2025-06-11
ER

PT J
AU Laudermilk, LT
   Harper, KM
   Moy, SS
   Runyon, S
   Zhou, B
   Koller, B
   Maitra, R
AF Laudermilk, Lucas T.
   Harper, Kathryn M.
   Moy, Sheryl S.
   Runyon, Scott
   Zhou, Bin
   Koller, Beverly
   Maitra, Rangan
TI Aplnr knockout mice display sex-specific changes in conditioned fear
SO BEHAVIOURAL BRAIN RESEARCH
LA English
DT Article
DE Apelin; receptor; behavior; conditioned fear; PTSD
ID ORPHAN RECEPTOR APJ; APELIN RECEPTOR; ENDOGENOUS LIGAND; PEPTIDE APELIN;
   SUPPRESSES APOPTOSIS; CONTEXTUAL FEAR; BLOOD-PRESSURE; EXPRESSION;
   EXTINCTION; KINASE
AB The G-protein-coupled receptor APLNR and its ligands apelin and ELABELA/TODDLER/apela comprise the apelinergic system, a signaling pathway that is critical during development and physiological homeostasis. Targeted regulation of the receptor has been proposed to treat several important diseases including heart failure, pulmonary arterial hypertension and metabolic syndrome. The apelinergic system is widely expressed within the central nervous system (CNS). However, the role of this system in the CNS has not been completely elucidated.
   Utilizing an Aplnr knockout mouse model, we report here results from tests of sensory ability, locomotion, reward preference, social preference, learning and memory, and anxiety. We find that knockout of Aplnr leads to significant effects on acoustic startle response and sex-specific effects on conditioned fear responses without significant changes in baseline anxiety. In particular, male Aplnr knockout mice display enhanced context- and cue-dependent fear responses. Our results complement previous reports that exogenous Apelin administration reduced conditioned fear and freezing responses in rodent models, and future studies will explore the therapeutic benefit of APLNR-targeted drugs in rodent models of PTSD.
C1 [Laudermilk, Lucas T.; Runyon, Scott; Maitra, Rangan] RTI Int, Ctr Drug Discovery, Res Triangle Pk, NC USA.
   [Harper, Kathryn M.; Moy, Sheryl S.] Univ N Carolina, Dept Psychiat, Chapel Hill, NC 27599 USA.
   [Harper, Kathryn M.; Moy, Sheryl S.] Univ N Carolina, Carolina Inst Dev Disabil, Chapel Hill, NC 27599 USA.
   [Zhou, Bin] Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, 320 Yueyang Rd,Life Sci Res Bldg A-2112, Shanghai 200031, Peoples R China.
   [Koller, Beverly] Univ N Carolina, Sch Med, Dept Genet, Chapel Hill, NC 27599 USA.
C3 Research Triangle Institute; University of North Carolina; University of
   North Carolina Chapel Hill; University of North Carolina; University of
   North Carolina Chapel Hill; Chinese Academy of Sciences; Center for
   Excellence in Molecular Cell Science, CAS; University of North Carolina
   School of Medicine; University of North Carolina; University of North
   Carolina Chapel Hill
RP Maitra, R (corresponding author), POB 12194, Res Triangle Pk, NC 27709 USA.
EM rmaitra@rti.org
RI Ezzell, Jennifer/ABF-6317-2021
OI Ezzell, Jennifer/0000-0002-5142-4685; Laudermilk,
   Lucas/0000-0001-6181-0136; Harper, Kathryn/0000-0002-6297-0032
FU RTI International; NIH [U01HG004085]; CSD Consortium [U01HG004080];
   CHORI [U42RR024244]; Eunice Kennedy Shriver National Institute of Child
   Health and Human Development (NICHD) [U54 HD079124];  [R01DK103625];
   National Institute of Diabetes and Digestive and Kidney Diseases
   [R01DK103625] Funding Source: NIH RePORTER
FX This work has been supported by R01DK103625 to R.M. and internal funding
   from RTI International.The knockout mouse strain used for this research
   project was generated by the trans-NIH Knock-Out Mouse Project (KOMP)
   and obtained from the KOMP Repository (www.komp.org).NIH grants to
   Velocigene at Regeneron Inc (U01HG004085) and the CSD Consortium
   (U01HG004080) funded the generation of gene-targeted ES cells for 8500
   genes in the KOMP Program and archived and distributed by the KOMP
   Repository at UC Davis and CHORI (U42RR024244).The UNC CIDD Mouse
   Behavioral Phenotyping Laboratory is funded by the Eunice Kennedy
   Shriver National Institute of Child Health and Human Development (NICHD;
   U54 HD079124).Histological services provided by the Histology Research
   Core Facility in the Department of Cell Biology and Physiology at the
   University of North Carolina, Chapel Hill NC.
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NR 66
TC 1
Z9 1
U1 0
U2 3
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0166-4328
EI 1872-7549
J9 BEHAV BRAIN RES
JI Behav. Brain Res.
PD FEB 26
PY 2021
VL 400
AR 113059
DI 10.1016/j.bbr.2020.113059
PG 10
WC Behavioral Sciences; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Behavioral Sciences; Neurosciences & Neurology
GA PT4SQ
UT WOS:000608605300001
PM 33309737
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Sorrentino, SA
   Besler, C
   Rohrer, L
   Meyer, M
   Heinrich, K
   Bahlmann, FH
   Mueller, M
   Horváth, T
   Doerries, C
   Heinemann, M
   Flemmer, S
   Markowski, A
   Manes, C
   Bahr, MJ
   Haller, H
   von Eckardstein, A
   Drexler, H
   Landmesser, U
AF Sorrentino, Sajoscha A.
   Besler, Christian
   Rohrer, Lucia
   Meyer, Martin
   Heinrich, Kathrin
   Bahlmann, Ferdinand H.
   Mueller, Maja
   Horvath, Tibor
   Doerries, Carola
   Heinemann, Mariko
   Flemmer, Stella
   Markowski, Andrea
   Manes, Costantina
   Bahr, Matthias J.
   Haller, Hermann
   von Eckardstein, Arnold
   Drexler, Helmut
   Landmesser, Ulf
TI Endothelial-Vasoprotective Effects of High-Density Lipoprotein Are
   Impaired in Patients With Type 2 Diabetes Mellitus but Are Improved
   After Extended-Release Niacin Therapy
SO CIRCULATION
LA English
DT Article
DE diabetes mellitus; endothelium; free radicals; lipids; nitric oxide
ID REVERSE CHOLESTEROL TRANSPORT; PROGENITOR-CELL MOBILIZATION; VASCULAR
   OXIDATIVE STRESS; SCAVENGER RECEPTOR-BI; NITRIC-OXIDE SYNTHASE;
   DOUBLE-BLIND; METABOLIC SYNDROME; HDL CHOLESTEROL; TORCETRAPIB;
   SIMVASTATIN
AB Background-High-density lipoprotein (HDL)-raising therapies are currently under intense evaluation, but the effects of HDL may be highly heterogeneous. We therefore compared the endothelial effects of HDL from healthy subjects and from patients with type 2 diabetes mellitus and low HDL (meeting the criteria for metabolic syndrome), who are frequently considered for HDL-raising therapies. Moreover, in diabetic patients, we examined the impact of extended-release (ER) niacin therapy on the endothelial effects of HDL.
   Methods and Results-HDL was isolated from healthy subjects (n = 10) and patients with type 2 diabetes (n = 33) by sequential ultracentrifugation. Effects of HDL on endothelial nitric oxide and superoxide production were characterized by electron spin resonance spectroscopy analysis. Effects of HDL on endothelium-dependent vasodilation and early endothelial progenitor cell-mediated endothelial repair were examined. Patients with diabetes were randomized to a 3-month therapy with ER niacin (1500 mg/d) or placebo, and endothelial effects of HDL were characterized. HDL from healthy subjects stimulated endothelial nitric oxide production, reduced endothelial oxidant stress, and improved endothelium-dependent vasodilation and early endothelial progenitor cell-mediated endothelial repair. In contrast, these beneficial endothelial effects of HDL were not observed in HDL from diabetic patients, which suggests markedly impaired endothelial-protective properties of HDL. ER niacin therapy improved the capacity of HDL to stimulate endothelial nitric oxide, to reduce superoxide production, and to promote endothelial progenitor cell-mediated endothelial repair. Further measurements suggested increased lipid oxidation of HDL in diabetic patients, and a reduction after ER niacin therapy.
   Conclusions-HDL from patients with type 2 diabetes mellitus and metabolic syndrome has substantially impaired endothelial-protective effects compared with HDL from healthy subjects. ER niacin therapy not only increases HDL plasma levels but markedly improves endothelial-protective functions of HDL in these patients, which is potentially more important.
C1 [Sorrentino, Sajoscha A.; Besler, Christian; Meyer, Martin; Mueller, Maja; Horvath, Tibor; Doerries, Carola; Heinemann, Mariko; Flemmer, Stella; Markowski, Andrea; Manes, Costantina; Drexler, Helmut; Landmesser, Ulf] Hannover Med Sch, Klin Kardiol & Angiol, D-30623 Hannover, Germany.
   [Sorrentino, Sajoscha A.; Bahlmann, Ferdinand H.; Haller, Hermann] Hannover Med Sch, Klin Nieren & Hochdruck Erkrankungen, D-30623 Hannover, Germany.
   [Markowski, Andrea; Bahr, Matthias J.] Hannover Med Sch, Klin Gastroenterol Hepatol & Endokrinol, D-30623 Hannover, Germany.
   [Besler, Christian; Meyer, Martin; Heinrich, Kathrin; Mueller, Maja; Doerries, Carola; Manes, Costantina; Landmesser, Ulf] Univ Zurich Hosp, Ctr Cardiovasc, CH-8091 Zurich, Switzerland.
   [Rohrer, Lucia; von Eckardstein, Arnold] Univ Zurich, Inst Clin Chem, Zurich, Switzerland.
   [Besler, Christian; Rohrer, Lucia; von Eckardstein, Arnold; Landmesser, Ulf] Univ Zurich, Zurich Ctr Integrated Human Physiol, Zurich, Switzerland.
C3 Hannover Medical School; Hannover Medical School; Hannover Medical
   School; University of Zurich; University Zurich Hospital; University of
   Zurich; University of Zurich; Zurich Center Integrative Human Physiology
   (ZIHP)
RP Landmesser, U (corresponding author), Univ Zurich Hosp, Ctr Cardiovasc, Ramistr 100,C Hof 111, CH-8091 Zurich, Switzerland.
EM Ulf.Landmesser@usz.ch
RI Landmesser, Ulf/NJT-0954-2025; Bahr, Matthias/AGR-8512-2022; Meyer,
   Martin/H-4307-2012
OI Bahr, Matthias J./0000-0001-6242-5299
FU Deutsche Forschungsgemeinschaft [LA 1432/4-1]; Merck (Darmstadt,
   Germany); Swiss National Research Foundation [3100A0-116404/1]; European
   Union [LSHM-C-2006-037631]; Zurich Center of Integrated Human Physiology
   (University of Zurich, Zurich, Switzerland)
FX This work was supported by the Deutsche Forschungsgemeinschaft (LA
   1432/4-1) and a research grant from Merck (Darmstadt, Germany).
   Furthermore, the project was supported by the Swiss National Research
   Foundation (grant 3100A0-116404/1), a European Union grant
   (LSHM-C-2006-037631), and the Zurich Center of Integrated Human
   Physiology (University of Zurich, Zurich, Switzerland).
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NR 53
TC 333
Z9 353
U1 1
U2 14
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0009-7322
EI 1524-4539
J9 CIRCULATION
JI Circulation
PD JAN 5
PY 2010
VL 121
IS 1
BP 110
EP 122
DI 10.1161/CIRCULATIONAHA.108.836346
PG 13
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 539PH
UT WOS:000273267700015
PM 20026785
OA Green Accepted, Bronze, Green Submitted
DA 2025-06-11
ER

PT J
AU Nieto-Martinez, R
   De Oliveira-Gomes, D
   Gonzalez-Rivas, JP
   Al-Rousan, T
   Mechanick, JI
   Danaei, G
AF Nieto-Martinez, Ramfis
   De Oliveira-Gomes, Diana
   Gonzalez-Rivas, Juan P.
   Al-Rousan, Tala
   Mechanick, Jeffrey I.
   Danaei, Goodarz
TI Telehealth and cardiometabolic-based chronic disease: optimizing
   preventive care in forcibly displaced migrant populations
SO JOURNAL OF HEALTH POPULATION AND NUTRITION
LA English
DT Review
DE Cardiometabolic; Chronic Disease; Hypertension; Migrants; Preventive
   medicine; Telehealth; Type 2 diabetes
ID CLINICAL ENDOCRINOLOGISTS; AMERICAN ASSOCIATION; HEALTH-CARE; ADIPOSITY
AB The number of migrants, which includes forcibly displaced refugees, asylum seekers, and undocumented persons, is increasing worldwide. The global migrant population is heterogeneous in terms of medical conditions and vulnerability resulting from non-optimal metabolic risk factors in the country of origin (e.g., abnormal adiposity, dysglycemia, hypertension, and dyslipidemia), adverse travel conditions and the resulting stress, poverty, and anxiety, and varying effects of acculturation and access to healthcare services in the country of destination. Therefore, many of these migrants develop a high risk for cardiovascular disease and face the significant challenge of overcoming economic and health system barriers to accessing quality healthcare. In the host countries, healthcare professionals experience difficulties providing care to migrants, including cultural and language barriers, and limited institutional capacities, especially for those with non-legal status. Telehealth is an effective strategy to mitigate cardiometabolic risk factors primarily by promoting healthy lifestyle changes and pharmacotherapeutic adjustments. In this descriptive review, the role of telehealth in preventing the development and progression of cardiometabolic disease is explored with a specific focus on type 2 diabetes and hypertension in forcibly displaced migrants. Until now, there are few studies showing that culturally adapted telehealth services can decrease the burden of T2D and HTN. Despite study limitations, telehealth outcomes are comparable to those of traditional health care with the advantages of having better accessibility for difficult-to-reach populations such as forcibly displaced migrants and reducing healthcare associated costs. More prospective studies implementing telemedicine strategies to treat cardiometabolic disease burden in migrant populations are needed.
C1 [Nieto-Martinez, Ramfis] Precis Care Clin Corp, St Cloud, FL 34769 USA.
   [Nieto-Martinez, Ramfis; Gonzalez-Rivas, Juan P.; Danaei, Goodarz] Harvard TH Chan Sch Publ Hlth, Dept Global Hlth & Populat & Epidemiol, Boston, MA 02115 USA.
   [Nieto-Martinez, Ramfis; De Oliveira-Gomes, Diana; Gonzalez-Rivas, Juan P.] Fdn Clin Publ Hlth Epidemiol Res Venezuela FISPEVE, Caracas, Venezuela.
   [De Oliveira-Gomes, Diana] Univ Texas Southwestern Med Ctr, Dept Internal Med, Dallas, TX USA.
   [Gonzalez-Rivas, Juan P.] St Annes Univ Hosp Brno FNUSA, Int Clin Res Ctr ICRC, Brno, Czech Republic.
   [Al-Rousan, Tala] Univ Calif San Diego, Herbert Wertheim Sch Publ Hlth & Human Longev Sci, La Jolla, CA USA.
   [Mechanick, Jeffrey I.] Icahn Sch Med Mt Sinai, Marie Josee & Henry R Kravis Ctr Cardiovasc Hlth M, New York, NY USA.
C3 Harvard University; Harvard T.H. Chan School of Public Health;
   University of Texas System; University of Texas Southwestern Medical
   Center Dallas; University of California System; University of California
   San Diego; Icahn School of Medicine at Mount Sinai
RP Nieto-Martinez, R (corresponding author), Precis Care Clin Corp, St Cloud, FL 34769 USA.; Nieto-Martinez, R (corresponding author), Harvard TH Chan Sch Publ Hlth, Dept Global Hlth & Populat & Epidemiol, Boston, MA 02115 USA.; Nieto-Martinez, R (corresponding author), Fdn Clin Publ Hlth Epidemiol Res Venezuela FISPEVE, Caracas, Venezuela.
EM nietoramfis@hsph.harvard.edu
RI Danaei, Goodarz/B-6085-2008; Gonzalez Rivas, Juan Pablo/HZK-6756-2023;
   Martinez, Andrea/KHX-0081-2024
OI De Oliveira, Diana/0000-0002-1207-1784; Danaei,
   Goodarz/0000-0003-2456-5463; Al-Rousan, Tala/0000-0001-8274-924X;
   mechanick, jeffrey/0000-0002-0657-588X; Nieto-Martinez,
   Ramfis/0000-0002-0575-7534
FU Not applicable.
FX Not applicable.
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NR 63
TC 3
Z9 4
U1 0
U2 6
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1606-0997
EI 2072-1315
J9 J HEALTH POPUL NUTR
JI J. Heatlh Popul. Nutr.
PD SEP 4
PY 2023
VL 42
IS 1
AR 93
DI 10.1186/s41043-023-00418-x
PG 10
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA Q8AB4
UT WOS:001059684200001
PM 37667387
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Biganeh, J
   Kalantari, V
   Shekaftik, SO
   Sheikhmozafari, MJ
   Talebi, SS
   Ebrahimi, MH
AF Biganeh, Jamal
   Kalantari, Vanoushe
   Shekaftik, Soqrat Omari
   Sheikhmozafari, Mohammad Javad
   Talebi, Seyedeh Solmaz
   Ebrahimi, Mohammad Hossein
TI Assessment of Public Health Indicators Among Professional Drivers in
   Shahroud City: A Cross-Sectional Survey
SO JOURNAL OF HEALTH AND SAFETY AT WORK
LA English
DT Article
DE Professional driver; Driving; Public health; Accident
ID COMMERCIAL TRUCK DRIVERS; METABOLIC SYNDROME; PREVALENCE; STRESS; SLEEP;
   RELIABILITY; VALIDITY; VERSION
AB Introduction: Driving has various harmful factors due to its nature, which affect drivers' health directly and indirectly. Therefore, it is necessary to know the situation and prevalence of these factors in drivers to implement preventive measures. Material and Methods: This cross-sectional study is a part of a cohort study conducted (2016 to 2018) among the professional drivers of Shahroud, Iran. Data related to background information, blood pressure, performance indicators, sleep disorders, and accidents were collected from the participants with standard tools and methods. Results: This study examined 1461 male professional drivers with an average age of 37.30 +/- 6.96 years. A total of 426 participants had metabolic syndrome. 797 and 942 people had different degrees of hearing loss, respectively, in the right and left ear. About 129 people had obstructive sleep apnea, and 1330 people had insomnia. Investigations showed that 351 drivers had at least one accident. Conclusion: This study showed the prevalence of health risk factors in professional drivers at the examined time point. Considering the vital role of drivers in transportation and the country's economy, it seems necessary to pay more attention to the health of this occupational group. Regular health screening, healthy lifestyle training, improvement of working conditions, and stress management are some interventions that can effectively improve drivers' health.
C1 [Biganeh, Jamal; Shekaftik, Soqrat Omari; Sheikhmozafari, Mohammad Javad] Univ Tehran Med Sci, Sch Publ Hlth, Dept Occupat Hlth, Tehran, Iran.
   [Biganeh, Jamal; Ebrahimi, Mohammad Hossein] Shahroud Univ Med Sci, Environm & Occupat Hlth Res Ctr, Shahroud, Iran.
   [Kalantari, Vanoushe] Shahroud Univ Med Sci, Student Res Comm, Sch Med, Shahroud, Iran.
   [Shekaftik, Soqrat Omari] Univ Tehran Med Sci, Students Sci Res Ctr, Tehran, Iran.
   [Talebi, Seyedeh Solmaz] Shahroud Univ Med Sci, Sch Publ Hlth, Dept Epidemiol, Shahroud, Iran.
C3 Tehran University of Medical Sciences; Shahroud University Medical
   Sciences; Shahroud University Medical Sciences; Tehran University of
   Medical Sciences; Shahroud University Medical Sciences
RP Ebrahimi, MH (corresponding author), Shahroud Univ Med Sci, Environm & Occupat Hlth Res Ctr, Shahroud, Iran.
EM ebrahimi_mh@hotmail.com
RI Omari Shekaftik, Soqrat/AHA-7280-2022; sheikhmozafari, mohammad
   javad/HLW-0578-2023; Biganeh, Jamal/IVH-5940-2023; Ebrahimi, Mohammad
   Hossein/I-3124-2017
OI Ebrahimi, Mohammad Hossein/0000-0002-1725-861X
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NR 49
TC 0
Z9 0
U1 1
U2 1
PU IRANIAN OCCUPATIONAL HEALTH ASSOC
PI TEHRAN
PA DEPT OCCUPATIONAL HEALTH, SCH PUBLIC HEALTH, PO BOX 13155-119, TEHRAN,
   00000, IRAN
SN 2251-807X
EI 2383-2088
J9 J HEALTH SAF WORK
JI J. Health Saf. Work
PY 2024
VL 14
IS 2
BP 349
EP 366
PG 18
WC Public, Environmental & Occupational Health
WE Emerging Sources Citation Index (ESCI)
SC Public, Environmental & Occupational Health
GA YH6K4
UT WOS:001267634800007
DA 2025-06-11
ER

PT J
AU Trzepizur, W
   Khalyfa, A
   Qiao, ZH
   Popko, B
   Gozal, D
AF Trzepizur, Wojciech
   Khalyfa, Abdelnaby
   Qiao, Zhuanhong
   Popko, Brian
   Gozal, David
TI Integrated stress response activation by sleep fragmentation during late
   gestation in mice leads to emergence of adverse metabolic phenotype in
   offspring
SO METABOLISM-CLINICAL AND EXPERIMENTAL
LA English
DT Article
DE Gestational sleep fragmentation; Integrated stress response; Metabolic
   syndrome; Insulin-resistance; Exosomes
ID ENDOPLASMIC-RETICULUM STRESS; UNFOLDED PROTEIN RESPONSE;
   INSULIN-RESISTANCE; ADIPOSE-TISSUE; OBESITY; DEPRIVATION; DISORDERS;
   EXOSOMES; HOMEOSTASIS; DYSFUNCTION
AB Background. Late gestational sleep fragmentation (SF) is highly prevalent particularly in obese women, and induces metabolic dysfunction in adult offspring mice. SF induces activation of the integrated stress response (ISR), which might be involved in metabolic disorders. We hypothesized that adult offspring of double mutant mice (DM) involving the critical ISR genes CHOP and GADD34 would be protected from developing obesity and insulin resistance following SF.
   Methods. Time-pregnant CHOP/GADD34 DM and wild type (WT) mice were randomly assigned to sleep control (SC) or SF conditions during the last 5 days of gestation. At 24-weeks of age, body weight, fat mass, and HOMA-IR were assessed in the offspring. Tregs lymphocytes, Lyc6c(high), M1 and M2 macrophages were examined in visceral white adipose tissues (vWAT) using flow cytometry. The effects of plasma exosomes on adipocyte cell line proliferation, differentiation and insulin sensitivity were also evaluated.
   Results. SF-WT male showed significant increases in body weight, vWAT mass and HOMA-IR compared to SC-WT mice, while SF had no effect in SF-DM mice. Inflammatory macrophages (Ly-6c(high)) and the ratio of MI/M2 macrophages were increased while FoxP3+ Tregs counts were decreased in SF-WT but not in SF-DM mice. Exosomes from SF-WT, but not from the SF-DM offspring increased pre-adipocyte proliferation and differentiation, and decreased in vitro adipocyte insulin sensitivity.
   Conclusion. Activation of the ISR during late gestation, as induced by late gestational SF, appears to underlie some of the transgenerational modifications in metabolic genes ultimately contributing to a metabolic syndrome phenotype in adult offspring. (C) 2017 Elsevier Inc. All rights reserved.
C1 [Trzepizur, Wojciech; Khalyfa, Abdelnaby; Qiao, Zhuanhong; Gozal, David] Univ Chicago, Div Biol Sci, Sect Sleep Med, Dept Pediat,Pritzker Sch Med, Chicago, IL 60637 USA.
   [Popko, Brian] Univ Chicago, Univ Chicago Ctr Peripheral Neuropathy, Dept Neurol, Chicago, IL 60637 USA.
C3 University of Chicago; University of Chicago
RP Gozal, D (corresponding author), Univ Chicago, Pritzker Sch Med, Dept Pediat, Sect Pediat Sleep Med,KCBD, Room 4100 900 E 57th St,Mailbox 4, Chicago, IL 60637 USA.
EM dgozal@uchicago.edu
RI Gozal, David/ABH-3805-2020; qiao, Zhuanhong/A-1117-2009; Khalyfa,
   Abdelnaby/M-9498-2017
OI Popko, Brian/0000-0001-9948-2553
FU Le Fonds de Dotation "Recherche en Sante Respiratoire" et La Fondation
   du Souffle; National Institutes of Health [NS034939]; Herbert T. Abelson
   Chair
FX d WT was supported by grants from Le Fonds de Dotation "Recherche en
   Sante Respiratoire" et La Fondation du Souffle. BP is supported by
   National Institutes of Health NS034939. This study was supported by the
   Herbert T. Abelson Chair to DG.
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NR 46
TC 18
Z9 18
U1 0
U2 10
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0026-0495
EI 1532-8600
J9 METABOLISM
JI Metab.-Clin. Exp.
PD APR
PY 2017
VL 69
BP 188
EP 198
DI 10.1016/j.metabol.2017.01.026
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA EP9MN
UT WOS:000397697800020
PM 28139216
DA 2025-06-11
ER

PT J
AU Afifi, AHM
   El-Bitar, HI
   Ahmed, MA
AF Afifi, Abdel-Halim M.
   El-Bitar, Hussein I.
   Ahmed, Marwa A.
TI EVALUATION OF POTENTIAL PROTECTIVE EFFECTS OF CURCUMIN VERSUS METFORMIN
   IN EXPERIMENTALLY-INDUCED METABOLIC SYNDROME IN RATS
SO BULLETIN OF PHARMACEUTICAL SCIENCES
LA English
DT Article
AB Metabolic syndrome (MetSyn) is the clustering of various interrelated risk factors of metabolic origin that increased incidence of cardiovascular diseases and type 2 diabetes. In this study the effectiveness of curcumin was evaluated in comparison with metformin in fructose-induced MetSyn disease in rats. Fructose was fed (10% solution in drinking water) for 8 weeks during which groups of rats were administered once daily vehicle (2% carboxy methyl cellulose), curcumin (40 and 80 mg/kg), metformin (100 and 200 mg/kg), their combinations and compared with group received tap water instead of fructose. The results revealed that induction of MetSyn was associated with glucose intolerance, insulin resistance alongside with increased weights of body and visceral fats. This was accompanied with an elevation of arterial blood pressure. Meanwhile, it caused disturbances in lipid profile (triglyceride, total cholesterol, HDL-C and LDL-C) and both oxidative stress (malondialdehyde, 8-iso-PGF(2 alpha) and superoxide dismutase) and inflammatory status (tumor necrosis factor-alpha interleukin-6, C-reactive protein and adiponectin) parameters. Each of curcumin and metformin significantly prevents, to variable extents, the progression of most of these signs of MetSyn. Furthermore, the efficacy of each of the two drugs in question was significantly augmented upon their concurrent administration. These protective effects of the two drugs under investigation presumably may be relevant to their ability to reduce the oxidative stress and to ameliorate the inflammatory processes.
C1 [Afifi, Abdel-Halim M.; El-Bitar, Hussein I.; Ahmed, Marwa A.] Assiut Univ, Dept Pharmacol, Fac Med, Assiut 71526, Egypt.
C3 Egyptian Knowledge Bank (EKB); Assiut University
RP Ahmed, MA (corresponding author), Assiut Univ, Dept Pharmacol, Fac Med, Assiut 71526, Egypt.
EM marwaabdelraheim@yahoo.com
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NR 55
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Z9 0
U1 1
U2 2
PU ASSIUT UNIV, FAC PHARMACY
PI ASSIUT
PA C/O DR SAMYA M EL-SAYED, ASSIUT, 00000, EGYPT
SN 1110-0052
J9 B PHARM SCI
JI Bull. Pharm. Sci.
PD DEC
PY 2014
VL 37
BP 77
EP 90
PN 2
PG 14
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA V47BR
UT WOS:000209927800002
DA 2025-06-11
ER

PT J
AU Benjamin, S
   Prakasan, P
   Sreedharan, S
   Wright, ADG
   Spener, F
AF Benjamin, Sailas
   Prakasan, Priji
   Sreedharan, Sajith
   Wright, Andre-Denis G.
   Spener, Friedrich
TI Pros and cons of CLA consumption: an insight from clinical evidences
SO NUTRITION & METABOLISM
LA English
DT Review
DE Conjugated linoleic acids; CLA; Review; Clinical evidences
ID CONJUGATED LINOLEIC-ACID; C-REACTIVE PROTEIN; REDUCES BODY-FAT;
   POSTMENOPAUSAL BREAST-CANCER; LIPID PROFILE; WEIGHT-LOSS; INSULIN
   SENSITIVITY; METABOLIC SYNDROME; GENE-EXPRESSION; IMMUNE FUNCTION
AB This comprehensive review critically evaluates whether supposed health benefits propounded upon human consumption of conjugated linoleic acids (CLAs) are clinically proven or not. With a general introduction on the chemistry of CLA, major clinical evidences pertaining to intervention strategies, body composition, cardio-vascular health, immunity, asthma, cancer and diabetes are evaluated. Supposed adverse effects such as oxidative stress, insulin resistance, irritation of intestinal tract and milk fat depression are also examined. It seems that no consistent result was observed even in similar studies conducted at different laboratories, this may be due to variations in age, gender, racial and geographical disparities, coupled with type and dose of CLA supplemented. Thus, supposed promising results reported in mechanistic and pre-clinical studies cannot be extrapolated with humans, mainly due to the lack of inconsistency in analyses, prolonged intervention studies, follow-up studies and international co-ordination of concerted studies. Briefly, clinical evidences accumulated thus far show that CLA is not eliciting significantly promising and consistent health effects so as to uphold it as neither a functional nor a medical food.
C1 [Benjamin, Sailas; Prakasan, Priji; Sreedharan, Sajith] Univ Calicut, Div Biotechnol, Dept Bot, Technol Enzymat Lab, Calicut 673635, Kerala, India.
   [Wright, Andre-Denis G.] Univ Arizona, Sch Anim & Comparat Biomed Sci, Tucson, AZ 85721 USA.
   [Spener, Friedrich] Graz Univ, Dept Mol Biosci, A-8010 Graz, Austria.
C3 University of Calicut; University of Arizona; University of Graz
RP Benjamin, S (corresponding author), Univ Calicut, Div Biotechnol, Dept Bot, Technol Enzymat Lab, Calicut 673635, Kerala, India.
EM benjamin@uoc.ac.in
RI WRIGHT, ANDRE-DENIS/ABI-2584-2020
FU Department of Biotechnology (DBT), Ministry of Science and Technology,
   Government of India [BT/PR 12714/FNS/20/411/2009]
FX The authors gratefully acknowledge the Department of Biotechnology
   (DBT), Ministry of Science and Technology, Government of India, for a
   research grant (No. BT/PR 12714/FNS/20/411/2009).
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NR 150
TC 89
Z9 92
U1 0
U2 55
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1743-7075
J9 NUTR METAB
JI Nutr. Metab.
PD FEB 3
PY 2015
VL 12
AR 4
DI 10.1186/1743-7075-12-4
PG 20
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA CC6SZ
UT WOS:000350500000001
PM 25972911
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Machado, FVC
   Pitta, F
   Hernandes, NA
   Bertolini, GL
AF Cavallari Machado, Felipe Vilaca
   Pitta, Fabio
   Hernandes, Nidia Aparecida
   Bertolini, Gisele Lopes
TI Physiopathological relationship between chronic obstructive pulmonary
   disease and insulin resistance
SO ENDOCRINE
LA English
DT Review
DE Pulmonary disease; Chronic obstructive; Insulin resistance; Diabetes
   mellitus; Risk factors
ID METABOLIC SYNDROME; INHALED CORTICOSTEROIDS; DIABETES-MELLITUS;
   CIGARETTE-SMOKING; PHYSICAL-ACTIVITY; SYSTEMIC INFLAMMATION;
   GLUCOSE-TOLERANCE; OXIDATIVE STRESS; LIPID-METABOLISM; SKELETAL-MUSCLE
AB Chronic obstructive pulmonary disease (COPD) is characterized by persistent and progressive airflow obstruction that is associated with an abnormal chronic inflammatory response in the airways and lungs to noxious particles. COPD often leads to physical inactivity and deconditioning that added to inappropriate/excessive inflammatory responses leads to systemic consequences. Studies have shown that metabolic syndrome and manifested diabetes are more frequent in COPD than in healthy subjects; a possible explanation is that different pathophysiological aspects of COPD can lead to insulin resistance. Thus, this mini-review aims to present the main studies suggesting a pathophysiological relationship between COPD and insulin resistance.
   A review of literature was conducted using PubMed and Web of Science databases with the aim of searching for studies supporting a relationship between COPD and insulin resistance.
   A physiopathological relationship between COPD and insulin resistance was found, supported in part due to common risk factors presented by these two conditions, such as smoking and physical inactivity. Also, systemic effects (worsening of physical inactivity and sedentary behavior, inflammation and oxidative stress, body composition abnormalities) and the corticosteroid treatment of patients with COPD may play a role.
   Patients with COPD should be screened for abnormalities in insulin sensitivity in order to reduce morbidity and improve health status in this population.
C1 [Cavallari Machado, Felipe Vilaca; Pitta, Fabio; Hernandes, Nidia Aparecida] State Univ Londrina UEL, Dept Physiotherapy, Lab Res Resp Physiotherapy LFIP, Londrina, Parana, Brazil.
   [Bertolini, Gisele Lopes] State Univ Londrina UEL, Dept Physiol Sci, Londrina, Parana, Brazil.
C3 Universidade Estadual de Londrina; Universidade Estadual de Londrina
RP Bertolini, GL (corresponding author), State Univ Londrina UEL, Dept Physiol Sci, Londrina, Parana, Brazil.
EM giselebertolini@uel.br
RI Bertolini, Gisele/LZI-2896-2025; Hernandes, Nidia/AAY-9196-2021; Pitta,
   Fabio/D-7875-2013; Machado, Felipe/AAA-7851-2020
OI Pitta, Fabio/0000-0002-3369-6660; Lopes Bertolini,
   Gisele/0000-0002-0161-937X; Machado, Felipe/0000-0003-1910-7695
FU Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES),
   Brazil
FX Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES),
   Brazil.
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NR 55
TC 31
Z9 31
U1 0
U2 11
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1355-008X
EI 1559-0100
J9 ENDOCRINE
JI Endocrine
PD JUL
PY 2018
VL 61
IS 1
BP 17
EP 22
DI 10.1007/s12020-018-1554-z
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA GJ2UQ
UT WOS:000435129400004
PM 29512058
DA 2025-06-11
ER

PT J
AU Venkatesan, V
   Madhira, SL
   Malakapalli, VM
   Chalasani, M
   Shaik, SN
   Seshadri, V
   Kodavalla, V
   Bhonde, RR
   Nappanveettil, G
AF Venkatesan, Vijayalakshmi
   Madhira, Soundarya L.
   Malakapalli, Venkata M.
   Chalasani, Maniprabha
   Shaik, Sarfaraz N.
   Seshadri, Vasudevan
   Kodavalla, Venkaiah
   Bhonde, Ramesh R.
   Nappanveettil, Giridharan
TI Obesity, Insulin Resistance, and Metabolic Syndrome: A Study in WNIN/Ob
   Rats from a Pancreatic Perspective
SO BIOMED RESEARCH INTERNATIONAL
LA English
DT Article
ID ENDOPLASMIC-RETICULUM STRESS; DIABETIC FATTY RATS; BETA-CELL MASS;
   OXIDATIVE STRESS; GENE-EXPRESSION; ANIMAL-MODELS; ISLET; SECRETION;
   LEPTIN; INFLAMMATION
AB Alterations in pancreatic milieu to adapt to physiological shifts occurring in conditions of obesity and metabolic syndrome (MS) have been documented, though mechanisms leading to such a state have remained elusive so far. The data presented here tries to look at the gravity of metabolic insult during the early and prolonged phases of obesity/insulin resistance (IR) depicted in WNIN/Ob strain of rats-an obese euglycemic mutant rat model developed indigenously at our institute which is highly vulnerable for a variety of degenerative diseases. The present results in situ show the participation of several confounding factors in the pancreatic milieu that collectively coprecipitates for a state of profound inflammation in the pancreas (among Mutant compared to Lean/Control) which gets worsened with age. These include hypertrophy, macrophage infiltration (CD11b/TNF alpha/IL6), apoptosis, beta-cell vacuolation, hyperinsulinemia (HI), and stressmarkers (RL-77/HSP104/TBARS) all of which correlated well with indices for obesity (2-3 fold), IR (1.5-3 fold), and HI (2-3 fold). Further, supportive data was also obtained from in vitro studies using islet cell cultures amongst phenotypes. Taken together, these results advocate that inflammation was the major precipitating factor to cause islet cell dysfunctions (in situ and in vitro) in these Mutant rats compared to their Lean littermates and parental Control.
C1 [Venkatesan, Vijayalakshmi; Madhira, Soundarya L.; Malakapalli, Venkata M.; Chalasani, Maniprabha; Shaik, Sarfaraz N.] Indian Council Med Res, Natl Inst Nutr, Dept Biochem Stem Cell Res, Hyderabad 500007, Andhra Pradesh, India.
   [Seshadri, Vasudevan] Natl Ctr Cell Sci, Lab 12, Pune 411007, Maharashtra, India.
   [Kodavalla, Venkaiah] Natl Inst Nutr, Div Community Studies, Hyderabad 500007, Andhra Pradesh, India.
   [Bhonde, Ramesh R.] Manipal Inst Regenerat Med, Bangalore 560065, Karnataka, India.
   [Nappanveettil, Giridharan] Natl Inst Nutr, Natl Ctr Lab Anim Sci, Hyderabad 500007, Andhra Pradesh, India.
C3 Indian Council of Medical Research (ICMR); ICMR - National Institute of
   Nutrition (NIN); Department of Biotechnology (DBT) India; National
   Centre for Cell Science, Pune (NCCS); Indian Council of Medical Research
   (ICMR); ICMR - National Institute of Nutrition (NIN); Manipal Academy of
   Higher Education (MAHE); Indian Council of Medical Research (ICMR); ICMR
   - National Institute of Nutrition (NIN); ICMR - National Animal Resource
   Facility for Biomedical Research (NARFBR)
RP Venkatesan, V (corresponding author), Indian Council Med Res, Natl Inst Nutr, Dept Biochem Stem Cell Res, Jamai Osmania PO, Hyderabad 500007, Andhra Pradesh, India.
EM v.venkateshan@gmail.com
RI BHONDE, RAMESH/C-1233-2009; Nawaz, Sarfaraz/N-8784-2019
OI Venkatesan, Vijayalakhsmi/0000-0002-3142-9657; Nawaz, Shaik
   Sarfaraz/0000-0002-2606-4112
FU National Institute of Nutrition, Indian Council of Medical Research,
   Hyderabad
FX The authors wish to thank the Director of the National Institute of
   Nutrition, Indian Council of Medical Research (Flagship Project),
   Hyderabad, for extending grant support to execute this work. They also
   thank Dr. NV Giridharan and Dr. P Suresh, the former and present,
   respectively, person in charge of NCLAS, for extending support to carry
   out the animal experiments. They deeply acknowledge help extended by Dr.
   P. Uday Kumar (Pathology Head) and his team for providing them with
   tissue sections.
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NR 66
TC 18
Z9 18
U1 0
U2 2
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2314-6133
EI 2314-6141
J9 BIOMED RES INT-UK
JI Biomed Res. Int.
PY 2013
VL 2013
AR 617569
DI 10.1155/2013/617569
PG 19
WC Biotechnology & Applied Microbiology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Research & Experimental Medicine
GA 280KK
UT WOS:000329028200001
PM 24455710
OA hybrid, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Kolb, H
   Mandrup-Poulsen, T
AF Kolb, H.
   Mandrup-Poulsen, T.
TI The global diabetes epidemic as a consequence of lifestyle-induced
   low-grade inflammation
SO DIABETOLOGIA
LA English
DT Review
DE Beta cell; Cytokines; Inflammation; Insulin resistance; Lifestyle;
   Macrophage; Pathogenesis; Review; Type 2 diabetes
ID C-REACTIVE PROTEIN; NECROSIS-FACTOR-ALPHA; FACTOR-KAPPA-B; INDUCED
   INSULIN-RESISTANCE; SKELETAL-MUSCLE CELLS; WHITE ADIPOSE-TISSUE;
   HIGH-FAT-DIET; HEALTHY-SUBJECTS; BETA-CELLS; METABOLIC SYNDROME
AB The recent major increase in the global incidence of type 2 diabetes suggests that most cases of this disease are caused by changes in environment and lifestyle. All major risk factors for type 2 diabetes (overnutrition, low dietary fibre, sedentary lifestyle, sleep deprivation and depression) have been found to induce local or systemic low-grade inflammation that is usually transient or milder in individuals not at risk for type 2 diabetes. By contrast, inflammatory responses to lifestyle factors are more pronounced and prolonged in individuals at risk of type 2 diabetes and appear to occur also in the pancreatic islets. Chronic low-grade inflammation will eventually lead to overt diabetes if counter-regulatory circuits to inflammation and metabolic stress are compromised because of a genetic and/or epigenetic predisposition. Hence, it is not the lifestyle change per se but a deficient counter-regulatory response in predisposed individuals which is crucial to disease pathogenesis. Novel approaches of intervention may target these deficient defence mechanisms.
C1 [Kolb, H.; Mandrup-Poulsen, T.] Hagedorn Res Inst, DK-2820 Gentofte, Denmark.
   [Mandrup-Poulsen, T.] Univ Copenhagen, Fac Hlth Sci, Inst Biomed Sci, Ctr Med Res Methodol, Copenhagen, Denmark.
   [Mandrup-Poulsen, T.] Karolinska Inst, Dept Med & Surg, Stockholm, Sweden.
C3 Novo Nordisk; Hagedorn Research Institute; University of Copenhagen;
   Karolinska Institutet
RP Kolb, H (corresponding author), Hagedorn Res Inst, DK-2820 Gentofte, Denmark.
EM hubert.kolb@gmx.com
OI Mandrup-Poulsen, Thomas/0000-0002-3215-9273
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NR 100
TC 227
Z9 262
U1 0
U2 31
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0012-186X
J9 DIABETOLOGIA
JI Diabetologia
PD JAN
PY 2010
VL 53
IS 1
BP 10
EP 20
DI 10.1007/s00125-009-1573-7
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 529PV
UT WOS:000272530600003
PM 19890624
OA Bronze
DA 2025-06-11
ER

PT J
AU Shao, D
   Fry, JL
   Han, JY
   Hou, XY
   Pimentel, DR
   Matsui, R
   Cohen, RA
   Bachschmid, MM
AF Shao, Di
   Fry, Jessica L.
   Han, Jingyan
   Hou, Xiuyun
   Pimentel, David R.
   Matsui, Reiko
   Cohen, Richard A.
   Bachschmid, Markus M.
TI A Redox-resistant Sirtuin-1 Mutant Protects against Hepatic Metabolic
   and Oxidant Stress
SO JOURNAL OF BIOLOGICAL CHEMISTRY
LA English
DT Article
DE Glutathionylation; Metabolic Diseases; Oxidative Stress; Polyphenols;
   Resveratrol; Glutathiolation; High Fat High Sucrose Diet; Reactive
   Oxygen and Nitrogen Species
ID HIGH-FAT DIET; NF-KAPPA-B; REGULATES SIRT1; CELL-SURVIVAL; HEPATOCYTE
   APOPTOSIS; ANTIOXIDANT STATUS; LIVER; P53; EXPRESSION; PHOSPHORYLATION
AB Background: Sirtuin-1 improves metabolic disease, but oxidants may inhibit it. Results: Metabolic stress increased glutathione adducts, inactivated endogenous Sirtuin-1, and promoted apoptosis. A novel Sirtuin-1 oxidation-insensitive mutant or glutaredoxin-1 prevented metabolic dysregulation and apoptosis. Conclusion: A novel Sirtuin-1 mutant circumvents oxidation and more effectively inhibits metabolic dysregulation and apoptosis. Significance: Oxidative inactivation of Sirtuin-1 contributes to metabolic disease.
   Sirtuin-1 (SirT1), a member of the NAD(+)-dependent class III histone deacetylase family, is inactivated in vitro by oxidation of critical cysteine thiols. In a model of metabolic syndrome, SirT1 activation attenuated apoptosis of hepatocytes and improved liver function including lipid metabolism. We show in SirT1-overexpressing HepG2 cells that oxidants (nitrosocysteine and hydrogen peroxide) or metabolic stress (high palmitate and high glucose) inactivated SirT1 by reversible oxidative post-translational modifications (OPTMs) on three cysteines. Mutating these oxidation-sensitive cysteines to serine preserved SirT1 activity and abolished reversible OPTMs. Overexpressed mutant SirT1 maintained deacetylase activity and attenuated proapoptotic signaling, whereas overexpressed wild type SirT1 was less protective in metabolically or oxidant-stressed cells. To prove that OPTMs of SirT1 are glutathione (GSH) adducts, glutaredoxin-1 was overexpressed to remove this modification. Glutaredoxin-1 overexpression maintained endogenous SirT1 activity and prevented proapoptotic signaling in metabolically stressed HepG2 cells. The in vivo significance of oxidative inactivation of SirT1 was investigated in livers of high fat diet-fed C57/B6J mice. SirT1 deacetylase activity was decreased in the absence of changes in SirT1 expression and associated with a marked increase in OPTMs. These results indicate that glutathione adducts on specific SirT1 thiols may be responsible for dysfunctional SirT1 associated with liver disease in metabolic syndrome.
C1 [Shao, Di; Fry, Jessica L.; Han, Jingyan; Hou, Xiuyun; Matsui, Reiko; Cohen, Richard A.; Bachschmid, Markus M.] Boston Univ, Sch Med, Vasc Biol Sect, Boston, MA 02118 USA.
   [Pimentel, David R.] Boston Univ, Sch Med, Whitaker Cardiovasc Inst, Myocardial Biol Unit, Boston, MA 02118 USA.
   [Cohen, Richard A.; Bachschmid, Markus M.] Boston Univ, Sch Med, Cardiovasc Proteom Ctr, Boston, MA 02118 USA.
C3 Boston University; Boston University; Boston University
RP Bachschmid, MM (corresponding author), Boston Univ, Sch Med, Whitaker Cardiovasc Inst, Vasc Biol Sect, Boston, MA 02118 USA.
EM bach@bu.edu
RI Shao, Di/F-9758-2016; han, jingyan/HJG-6568-2022
OI Fry, Jessica/0000-0003-2748-0334; /0000-0002-1070-6408; Bachschmid,
   Markus Michael/0000-0002-0748-5528
FU National Institutes of Health [PO1 HL 068758, R37 HL104017]; NHLBI,
   National Institutes of Health, Department of Health and Human Services
   [HHSN268201000031C]; National Institutes of Health Cardiovascular
   Post-doctoral Training Grant [HL007224]
FX This work was supported, in whole or in part, by National Institutes of
   Health Grants PO1 HL 068758 and R37 HL104017 and the NHLBI, National
   Institutes of Health, Department of Health and Human Services under
   Contract HHSN268201000031C.Supported by National Institutes of Health
   Cardiovascular Post-doctoral Training Grant HL007224.
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NR 72
TC 60
Z9 62
U1 0
U2 14
PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3996 USA
EI 1083-351X
J9 J BIOL CHEM
JI J. Biol. Chem.
PD MAR 14
PY 2014
VL 289
IS 11
BP 7293
EP 7306
DI 10.1074/jbc.M113.520403
PG 14
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA AC8CV
UT WOS:000332761500004
PM 24451382
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Yokota, T
   Kinugawa, S
   Yamato, M
   Hirabayashi, K
   Suga, T
   Takada, S
   Harada, K
   Morita, N
   Oyama-Manabe, N
   Kikuchi, Y
   Okita, K
   Tsutsui, H
AF Yokota, Takashi
   Kinugawa, Shintaro
   Yamato, Mayumi
   Hirabayashi, Kagami
   Suga, Tadashi
   Takada, Shingo
   Harada, Kuniaki
   Morita, Noriteru
   Oyama-Manabe, Noriko
   Kikuchi, Yasuka
   Okita, Koichi
   Tsutsui, Hiroyuki
TI Systemic Oxidative Stress Is Associated With Lower Aerobic Capacity and
   Impaired Skeletal Muscle Energy Metabolism in Patients With Metabolic
   Syndrome
SO DIABETES CARE
LA English
DT Article
ID LOW CARDIORESPIRATORY FITNESS; INSULIN-RESISTANCE; MITOCHONDRIAL
   DYSFUNCTION; DIABETES-MELLITUS; WEIGHT-LOSS; MORTALITY; OBESITY;
   INDIVIDUALS; RESPIRATION; EXERCISE
AB OBJECTIVE-Systemic oxidative stress is associated with insulin resistance and obesity. We tested the hypothesis that systemic oxidative stress is linked to lower aerobic capacity and skeletal muscle dysfunction in metabolic syndrome (MetS).
   RESEARCH DESIGN AND METHODS-The incremental exercise testing with cycle ergometer was performed in 14 male patients with MetS and 13 age-, sex-, and activity-matched healthy subjects. Systemic lipid peroxidation was assessed by serum thiobarbituric acid reactive substances (TBARS), and systemic antioxidant defense capacity was assessed by serum total thiols and enzymatic activity of superoxide dismutase (SOD). To assess skeletal muscle energy metabolism, we measured high-energy phosphates in the calf muscle during plantar flexion exercise and intramyocellular lipid (IMCL) in the resting leg muscle, using P-31- and (1)proton-magnetic resonance spectroscopy, respectively.
   RESULTS-Serum TBARS were elevated (12.4 +/- 7.1 vs. 3.7 +/- 1.1 mu mol/L; P < 0.01), and serum total thiols and SOD activity were decreased (290.8 +/- 51.2 vs. 398.7 +/- 105.2 mu mol/L, P < 0.01; and 22.2 +/- 8.4 vs. 31.5 +/- 8.5 units/L, P < 0.05, respectively) in patients with MetS compared with healthy subjects. Peak VO2 and anaerobic threshold normalized to body weight were significantly lower in MetS patients by 25 and 31%, respectively, and inversely correlated with serum TBARS (r = -0.49 and r = -0.50, respectively). Moreover, muscle phosphocreatine loss during exercise was 1.4-fold greater in patients with MetS (P < 0.05), and IMCL content was 2.9-fold higher in patients with MetS (P < 0.01), indicating impaired skeletal muscle energy metabolism, and these indices positively correlated with serum TBARS (r = 0.45 and r = 0.63, respectively).
   CONCLUSIONS-Systemic oxidative stress was associated with lower aerobic capacity and impaired skeletal muscle energy metabolism in patients with MetS.
C1 [Yokota, Takashi; Kinugawa, Shintaro; Hirabayashi, Kagami; Suga, Tadashi; Takada, Shingo; Tsutsui, Hiroyuki] Hokkaido Univ Grad Sch Med, Dept Cardiovasc Med, Sapporo, Hokkaido, Japan.
   [Yokota, Takashi] Univ Copenhagen, Ctr Hlth Aging, Dept Biomed Sci, Copenhagen, Denmark.
   [Yamato, Mayumi] Kyushu Univ, Innovat Ctr Med Redox Nav, Fukuoka 812, Japan.
   [Suga, Tadashi; Takada, Shingo] Japan Soc Promot Sci, Tokyo, Japan.
   [Harada, Kuniaki] Sapporo Med Univ, Div Radiol, Sapporo, Hokkaido, Japan.
   [Morita, Noriteru] Hokkaido Univ, Dept Sports Educ, Iwamizawa, Japan.
   [Oyama-Manabe, Noriko; Kikuchi, Yasuka] Hokkaido Univ Hosp, Dept Diagnost & Intervent Radiol, Sapporo, Hokkaido 060, Japan.
   [Okita, Koichi] Hokusho Univ, Grad Sch Program Lifelong Learning Studies, Ebetsu, Hokkaido, Japan.
C3 Hokkaido University; University of Copenhagen; Kyushu University; Japan
   Society for the Promotion of Science; Sapporo Medical University;
   Hokkaido University; Hokkaido University
RP Kinugawa, S (corresponding author), Hokkaido Univ Grad Sch Med, Dept Cardiovasc Med, Sapporo, Hokkaido, Japan.
EM tuckahoe@med.hokudai.ac.jp
RI Kinugawa, Shintaro/E-1268-2012; Morita, Noriteru/U-1189-2019; 真鍋,
   徳子/JZD-4246-2024
OI Morita, Noriteru/0000-0003-3427-7174
FU Ministry of Education, Culture, Sports, Science, and Technology of Japan
   [18790487, 17390223, 20117004, 21390236]; Meiji Yasuda Life Foundation
   of Health and Welfare; Mitsui Life Social Welfare Foundation; Uehara
   Memorial Foundation; Grants-in-Aid for Scientific Research [18790487,
   21390236, 25882041, 17390223, 23500784, 20117004] Funding Source: KAKEN
FX This study was supported by grants from the Ministry of Education,
   Culture, Sports, Science, and Technology of Japan (18790487, 17390223,
   20117004, and 21390236), Meiji Yasuda Life Foundation of Health and
   Welfare, Mitsui Life Social Welfare Foundation, and the Uehara Memorial
   Foundation.
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NR 35
TC 50
Z9 54
U1 0
U2 12
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0149-5992
EI 1935-5548
J9 DIABETES CARE
JI Diabetes Care
PD MAY
PY 2013
VL 36
IS 5
BP 1341
EP 1346
DI 10.2337/dc12-1161
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 155WW
UT WOS:000319782100044
PM 23393211
OA Green Submitted, Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Chan, MY
   Lee, BJ
   Chang, PS
   Hsiao, HY
   Hsu, LP
   Chang, CH
   Lin, PT
AF Chan, Man-Yee
   Lee, Bor-Jen
   Chang, Po-Sheng
   Hsiao, Han-Yu
   Hsu, Li-Ping
   Chang, Chia-Hua
   Lin, Ping-Ting
TI The risks of ubiquinone and β-carotene deficiency and metabolic
   disorders in patients with oral cancer
SO BMC CANCER
LA English
DT Article
DE Ubiquinone; beta-Carotene; Antioxidant vitamins; Metabolic disorders;
   Oral cancer
ID ANTIOXIDANT STATUS; OXIDATIVE STRESS; ALPHA-TOCOPHEROL; SUBSEQUENT RISK;
   SERUM; BLOOD; INFLAMMATION; PRECANCER; CAPACITY; VITAMINS
AB BackgroundCancer development is mediated by oxidative stress and inflammation, which may correlate with metabolic disorders. The aim of this study was to evaluate antioxidant vitamins status and metabolic parameters in patients with oral cancer according to tumor-node-metastasis (TNM) stages.MethodsA total of 194 patients with oral cancer were enrolled in this study. The patients were stratified for four groups according to cancer stages and that the statistics are comparisons across these groups. The levels of antioxidant vitamins (ubiquinone, beta -carotene, vitamin A and E), metabolic parameters, oxidative stress, antioxidant enzymes activity, and inflammatory markers were measured.ResultsMore than half of the subjects had high blood pressure, central obesity, hyperglycemia, and hyperlipidemia regardless of TNM stage. With regard to antioxidant vitamins status, 46 and 94% of patients had beta -carotene and ubiquinone deficiency, respectively. Patients in T3 and T4 stages had significantly lower antioxidant enzyme (catalase, p=0.03) activity and higher inflammatory markers levels (high sensitivity C-reactive protein and interleukin-6, p<0.01) than patients in the other stages. In addition, the level of -carotene was negatively associated with waist circumference, and ubiquinone was positively associated with the level of high-density lipoprotein cholesterol (p<0.05). Higher -carotene and ubiquinone levels were negatively associated with hypertriglyceridemia and the risk of metabolic syndrome (p<0.05).ConclusionsA high proportion of patients with oral cancer had ubiquinone or -carotene deficiency and metabolic disorders. The level of ubiquinone or beta -carotene was negatively associated with the risk of central obesity, hypertriglyceridemia, and metabolic syndrome. Since patients with oral cancer suffer from high oxidative stress and inflammation (particularly in the T3 and T4 stages), supplementation with antioxidant vitamins such as ubiquinone or beta -carotene could be preferentially applied.
C1 [Chan, Man-Yee; Hsiao, Han-Yu] Taichung Vet Gen Hosp, Div Oral & Maxillofacial Surg, Dept Stomatol, Taichung 407204, Taiwan.
   [Chan, Man-Yee] Chung Shan Med Univ, Sch Dent, Coll Oral Med, Taichung 402367, Taiwan.
   [Lee, Bor-Jen] Tungs Taichung Metro Harbor Hosp, Dept Internal Med, Taichung 433402, Taiwan.
   [Lee, Bor-Jen] Chung Shan Med Univ, Sch Med, Taichung 402367, Taiwan.
   [Chang, Po-Sheng; Hsu, Li-Ping; Chang, Chia-Hua; Lin, Ping-Ting] Chung Shan Med Univ, Dept Nutr, Taichung 402367, Taiwan.
   [Chang, Po-Sheng] Chung Shan Med Univ, Grad Program Nutr, Taichung 402367, Taiwan.
   [Lin, Ping-Ting] Chung Shan Med Univ Hosp, Dept Nutr, Taichung 402367, Taiwan.
C3 Taichung Veterans General Hospital; Chung Shan Medical University; Chung
   Shan Medical University; Chung Shan Medical University; Chung Shan
   Medical University; Chung Shan Medical University; Chung Shan Medical
   University Hospital
RP Lin, PT (corresponding author), Chung Shan Med Univ, Dept Nutr, Taichung 402367, Taiwan.; Lin, PT (corresponding author), Chung Shan Med Univ Hosp, Dept Nutr, Taichung 402367, Taiwan.
EM apt810@csmu.edu.tw
FU Ministry of Health and Welfare, Taiwan [MOHW103-TD-B-111-10,
   MOHW104-TDU-B-211-124004, MOHW105-TDU-B-211-134002,
   MOHW106-TDU-B-211-144002]; Taichung Veterans General Hospital
   [TCVGH-1085606C]
FX This study was supported by a grant from the Ministry of Health and
   Welfare, Taiwan (MOHW103-TD-B-111-10, MOHW104-TDU-B-211-124004,
   MOHW105-TDU-B-211-134002 and MOHW106-TDU-B-211-144002), and the Taichung
   Veterans General Hospital (TCVGH-1085606C). The funders had no role in
   the design of the study, collection, analysis, and interpretation of
   data or in writing the manuscript.
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TC 10
Z9 11
U1 1
U2 4
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2407
J9 BMC CANCER
JI BMC Cancer
PD APR 15
PY 2020
VL 20
IS 1
DI 10.1186/s12885-020-06839-9
PG 9
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA LK9OA
UT WOS:000531187700009
PM 32293339
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Román-Malo, L
   Bullon, P
AF Roman-Malo, Lourdes
   Bullon, Pedro
TI Influence of the Periodontal Disease, the Most Prevalent Inflammatory
   Event, in Peroxisome Proliferator-Activated Receptors Linking Nutrition
   and Energy Metabolism
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE periodontitis; inflammasome; mitochondria; autophagy; atherosclerosis;
   diabetes; metabolic syndrome
ID GAMMA GENE POLYMORPHISM; BONE-MINERAL DENSITY; PORPHYROMONAS-GINGIVALIS;
   OXIDATIVE STRESS; ADIPOSE-TISSUE; FREE-RADICALS; PPAR; EXPRESSION;
   OBESITY; LIPOPOLYSACCHARIDE
AB Periodontal disease is considered one of the main pathologic diseases occurring in humans. Its pathologic process involves inflammatory reactions producing periodontal bone resorption and the tooth loss. But some patients do not present an evident clinical inflammation with bone resorption, and in others, the inflammation is prominent without bone resorption. A key question could be to investigate a different way of responding to aggression. Inflammation requires a complex intracellular metabolic process, starting with the harmful recognition and activation of the inflammasome, continues the energy supply with the alteration of oxidative stress conditions, and finishes with the elimination of the aggression with autophagy/apoptosis mechanisms, then concludes with recovery. Peroxisome proliferator-activated receptors (PPARs) are essential molecules produced in inflammation, and its genes and its activation have been related to periodontal disease. Also, an important aspect is the influence of PPARs in bone metabolism; the main periodontitis symptom is bone loss and PPAR gamma activation that can downregulate the bone resorption in experimental periodontitis, PPAR gamma-coated titanium dental implant surfaces could carry the antiinflammatory gene and restrain inflammation. PPARs could be one of the meeting background points with atherosclerosis/cardiovascular disease, diabetes and metabolic syndrome showing a modified proinflammatory statement such as it is described in periodontitis.
C1 [Roman-Malo, Lourdes; Bullon, Pedro] Univ Seville, Dept Estomatol, Lab Invest, C Avicena S-N, E-41009 Seville, Spain.
C3 University of Sevilla
RP Bullon, P (corresponding author), Univ Seville, Dept Estomatol, Lab Invest, C Avicena S-N, E-41009 Seville, Spain.
EM lvrmalo@gmail.com; pbullon@us.es
RI Bullon, Pedro/E-6319-2010
OI Bullon, Pedro/0000-0003-4873-4196
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NR 80
TC 19
Z9 20
U1 3
U2 13
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD JUL
PY 2017
VL 18
IS 7
AR 1438
DI 10.3390/ijms18071438
PG 13
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA FF2SJ
UT WOS:000408746800108
PM 28678155
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Hiuge-Shimizu, A
   Maeda, N
   Hirata, A
   Nakatsuji, H
   Nakamura, K
   Okuno, A
   Kihara, S
   Funahashi, T
   Shimomura, I
AF Hiuge-Shimizu, Aki
   Maeda, Norikazu
   Hirata, Ayumu
   Nakatsuji, Hideaki
   Nakamura, Kouichi
   Okuno, Akira
   Kihara, Shinji
   Funahashi, Tohru
   Shimomura, Iichiro
TI Dynamic Changes of Adiponectin and S100A8 Levels by the Selective
   Peroxisome Proliferator-Activated Receptor-γ Agonist Rivoglitazone
SO ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
LA English
DT Article
DE adiponectin; inflammation; oxidative stress; peroxisome
   proliferator-activated receptor; S100A8
ID METABOLIC SYNDROME; OXIDATIVE STRESS; MYOCARDIAL-INFARCTION;
   INSULIN-RESISTANCE; NUCLEAR RECEPTORS; T-CELLS; INFLAMMATION; LIGANDS;
   PROTEIN; MICE
AB Objective-Accumulating evidence indicates that the regimen to increase adiponectin will provide a novel therapeutic strategy for metabolic syndrome. Here, we tested the effect of a potent and selective peroxisome proliferator-activated receptor-gamma agonist, rivoglitazone (Rivo), a newly synthesized thiazolidinedione derivative, on adiponectin, insulin resistance, and atherosclerosis.
   Methods and Results-ob/ob mice, apolipoprotein E knockout (apoE KO) mice, and apoE and adiponectin double knockout mice were administered pioglitazone, Rivo, or no compound. Remarkable elevation of plasma adiponectin was observed, especially in Rivo-treated ob/ob mice. Rivo ameliorated insulin resistance in ob/ob mice and reduced atherosclerotic areas in apoE KO mice compared with the pioglitazone group but failed to decrease atherosclerotic areas in double knockout mice. Among adipose mRNAs, adipose S100A8, which activates Toll-like receptor 4-dependent signal transduction cascades and locates upstream of inflammation, was markedly increased in ob/ob mice, and its increase was completely reversed by Rivo treatment. In RAW264.7 macrophage cells and 3T3-L1 adipocytes, Rivo significantly reduced S100A8 mRNA levels.
   Conclusion-The peroxisome proliferator-activated receptor-gamma agonist Rivo remarkably enhanced adiponectin in plasma and decreased adipose S100A8 mRNA levels in obese mice. Rivo treatment apparently ameliorated insulin resistance in ob/ob mice and reduced atherosclerosis in apoE KO mice, partly through adiponectin. (Arterioscler Thromb Vasc Biol. 2011;31:792-799.)
C1 [Hiuge-Shimizu, Aki; Maeda, Norikazu; Hirata, Ayumu; Nakatsuji, Hideaki; Kihara, Shinji; Funahashi, Tohru; Shimomura, Iichiro] Osaka Univ, Grad Sch Med, Dept Metab Med, Suita, Osaka 5650871, Japan.
   [Nakamura, Kouichi] Daiichi Sankyo Co Ltd, Drug Metab & Pharmacokinet Res Labs, Tokyo, Japan.
   [Okuno, Akira] Daiichi Sankyo Co Ltd, R&D Planning Dept, Tokyo, Japan.
C3 The University of Osaka; Daiichi Sankyo Company Limited; Daiichi Sankyo
   Company Limited
RP Maeda, N (corresponding author), Osaka Univ, Grad Sch Med, Dept Metab Med, 2-2,B5 Yamada Oka, Suita, Osaka 5650871, Japan.
EM norikazu_maeda@endmet.med.osaka-u.ac.jp
RI Kihara, Shinji/AAW-2015-2021; Maeda, Norikazu/LZI-4561-2025
FU [19390249];  [22590979]; Grants-in-Aid for Scientific Research
   [22590978, 22590979] Funding Source: KAKEN
FX This work was supported in part by Grants-in-Aid for Scientific Research
   B 19390249 (to T.F.) and C 22590979 (to N.M.).
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NR 35
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Z9 41
U1 0
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1079-5642
EI 1524-4636
J9 ARTERIOSCL THROM VAS
JI Arterioscler. Thromb. Vasc. Biol.
PD APR
PY 2011
VL 31
IS 4
BP 792
EP 799
DI 10.1161/ATVBAHA.110.221747
PG 8
WC Hematology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Hematology; Cardiovascular System & Cardiology
GA 735SP
UT WOS:000288437800014
PM 21233451
DA 2025-06-11
ER

PT J
AU Janczura, M
   Bochenek, G
   Nowobilski, R
   Dropinski, J
   Kotula-Horowitz, K
   Laskowicz, B
   Stanisz, A
   Lelakowski, J
   Domagala, T
AF Janczura, Miroslaw
   Bochenek, Grazyna
   Nowobilski, Roman
   Dropinski, Jerzy
   Kotula-Horowitz, Katarzyna
   Laskowicz, Bartosz
   Stanisz, Andrzej
   Lelakowski, Jacek
   Domagala, Teresa
TI The Relationship of Metabolic Syndrome with Stress, Coronary Heart
   Disease and Pulmonary Function - An Occupational Cohort-Based Study
SO PLOS ONE
LA English
DT Article
ID INTIMA-MEDIA THICKNESS; INCIDENT CARDIOVASCULAR EVENTS; REDUCED
   LUNG-FUNCTION; PHYSICAL-ACTIVITY; INSULIN-RESISTANCE; ARTERY-DISEASE;
   JOB STRAIN; PSYCHOSOCIAL STRESS; BLOOD-PRESSURE; YOUNG-ADULTS
AB Background and Aims
   Higher levels of stress impact the prevalence of metabolic syndrome (MetS) and coronary heart disease. The association between MetS, impaired pulmonary function and low level of physical activity is still pending assessment in the subjects exposed to stress. The study aimed to examine whether higher levels of stress might be related to MetS and the plaque presence, as well as whether MetS might affect pulmonary function.
   Design and Methods
   The study embraced 235 police officers (mean age 40.97 years) from the south of Poland. The anthropometrics and biochemical variables were measured; MetS was diagnosed using the International Diabetes Federation criteria. Computed tomography coronary angiography of coronary arteries, exercise ECG, measurements of brachial flow-mediated dilation, and carotid artery intima-media thickness were completed. In order to measure the self-perception of stress, 10-item Perceived Stress Scale (PSS-10) was applied. Pulmonary function and physical activity levels were also addressed. Multivariate logistic regression analyses were applied to determine the relationships between: 1/incidence of coronary plaque and MetS per se, MetS components and the number of classical cardiovascular risk factors, 2/perceived stress and MetS, 3/MetS and pulmonary function parameters.
   Results
   Coronary artery atherosclerosis was less associated with MetS (OR = 2.62, 95% CI 1.24-5.52; p = 0.011) than with a co-existence of classical cardiovascular risk factors (OR = 5.67, 95% CI 1.07-29.85, p = 0.03; for 3 risk factors and OR = 9.05; 95% CI 1.24-66.23, p = 0.02; for 6 risk factors, respectively). Perceived stress increased MetS prevalence (OR = 1.07, 95% CI 1.03-1.13; p = 0.03), and impacted coronary plaque prevalence (OR = 1.05, 95% CI 1.001-1.10; p = 0.04). Leisure-time physical activity reduced the chances of developing MetS (OR = 0.98 95% CI 0.96-0.99; p = 0.02). MetS subjects had significantly lower values of certain pulmonary function parameters.
   Conclusions
   Exposure to job-specific stress among police officers increased the prevalence of MetS and impacted coronary plaque presence. MetS subjects had worse pulmonary function parameters. Early-stage, comprehensive therapeutic intervention may reduce overall risk of cardiovascular events and prevent pulmonary function impairment in this specific occupational population.
C1 [Janczura, Miroslaw] John Paul 2 Hosp, Dept Anesthesiol & Intens Pulm Care, Krakow, Poland.
   [Bochenek, Grazyna; Nowobilski, Roman; Dropinski, Jerzy; Kotula-Horowitz, Katarzyna; Domagala, Teresa] Jagiellonian Univ, Sch Med, Dept Internal Med, Krakow, Poland.
   [Nowobilski, Roman] Jagiellonian Univ, Sch Med, Fac Publ Hlth, Unit Rehabil Internal Dis, Krakow, Poland.
   [Laskowicz, Bartosz] John Paul 2 Hosp, Dept Radiol & Diagnost Imaging, Krakow, Poland.
   [Stanisz, Andrzej] Jagiellonian Univ, Sch Med, Dept Bioinformat & Telemed, Krakow, Poland.
   [Lelakowski, Jacek] John Paul 2 Hosp, Inst Cardiol, Dept Electrocardiol, Krakow, Poland.
C3 Jagiellonian University; Jagiellonian University; Jagiellonian
   University; Jagiellonian University; Collegium Medicum Jagiellonian
   University
RP Domagala, T (corresponding author), Jagiellonian Univ, Sch Med, Dept Med Biochem, Krakow, Poland.
EM domagala32@yahoo.com
RI Janczura, Miroslaw/HSE-9726-2023
OI Janczura, Miroslaw/0000-0001-8485-0683; Domagala,
   Teresa/0000-0003-0747-5757
FU Leading National Research Centre
FX Project co-financed by the Leading National Research Centre 2012-2017.
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NR 89
TC 52
Z9 61
U1 1
U2 14
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD AUG 14
PY 2015
VL 10
IS 8
AR e0133750
DI 10.1371/journal.pone.0133750
PG 20
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Science & Technology - Other Topics
GA CO9KD
UT WOS:000359493600016
PM 26274823
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Jiraskova, A
   Skrha, J
   Vitek, L
AF Jiraskova, Alena
   Skrha, Jan
   Vitek, Libor
TI Association of Low Serum Bilirubin Concentrations and Promoter
   Variations in the UGT1A1 and HMOX1 Genes with Type 2
   Diabetes Mellitus in the Czech Population
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE benign hyperbilirubinemia; bilirubin; Gilbert syndrome; heme oxygenase;
   HMOX1; type 2 diabetes mellitus
ID GILBERT-SYNDROME; METABOLIC SYNDROME; OXIDATIVE STRESS; DISEASE;
   POLYMORPHISMS; PREVALENCE
AB Bilirubin has potent biological beneficial effects, protecting against atherosclerosis, obesity, and metabolic syndrome. The aim of this study was to assess serum bilirubin concentrations and (TA)(n) and (GT)(n) microsatellite variations in the promoter regions of the UGT1A1 and HMOX1 genes, respectively, in patients with type 2 diabetes mellitus (T2DM). The study was carried out in 220 patients with T2DM and 231 healthy control subjects, in whom standard biochemical tests were performed. The (TA)(n) and (GT)(n) dinucleotide variations were determined by means of fragment (size-based) analysis using an automated capillary DNA sequencer. Compared to controls, both male and female patients with T2DM had lower serum bilirubin concentrations (9.9 vs. 12.9 & mu;mol/L, and 9.0 vs. 10.6 & mu;mol/L, in men and women, respectively, p < 0.001). Phenotypic Gilbert syndrome was much less prevalent in T2DM patients, as was the frequency of the (TA)(7/7) UGT1A1 genotype in male T2DM patients. (GT)(n) HMOX1 genetic variations did not differ between diabetic patients and controls. Our results demonstrate that the manifestation of T2DM is associated with lower serum bilirubin concentrations. Consumption of bilirubin due to increased oxidative stress associated with T2DM seems to be the main explanation, although (TA)(n) repeat variations in UGT1A1 partially contribute to this phenomenon.
C1 [Jiraskova, Alena; Vitek, Libor] Charles Univ Prague, Gen Univ Hosp Prague, Inst Med Biochem & Lab Diagnost, Fac Med 1, Katerinska 32, Prague 12000, Czech Republic.
   [Skrha, Jan] Charles Univ Prague, Gen Univ Hosp Prague, Fac Med 1, Dept Internal Med 3, Katerinska 32, Prague 12000, Czech Republic.
   [Vitek, Libor] Charles Univ Prague, Gen Univ Hosp Prague, Fac Med 1, Dept Internal Med 4, Katerinska 32, Prague 12000, Czech Republic.
C3 Charles University Prague; General University Hospital Prague; General
   University Hospital Prague; Charles University Prague; General
   University Hospital Prague; Charles University Prague
RP Vitek, L (corresponding author), Charles Univ Prague, Gen Univ Hosp Prague, Inst Med Biochem & Lab Diagnost, Fac Med 1, Katerinska 32, Prague 12000, Czech Republic.
EM alena.jiraskova@immunai.com; jan.skrha@lf1.cuni.cz; vitek@cesnet.cz
RI Vitek, Libor/A-2645-2008
OI Vitek, Libor/0000-0002-5318-0151
FU Czech Ministry of Health [MH CZ-DRO-VFN64165]; Cooperatio Program,
   research area DIAG; National Institute for Research of Metabolic and
   Cardiovascular Diseases - European Union-Next Generation EU
   [LX22NPO5104]
FX This study was supported by grants MH CZ-DRO-VFN64165 from the Czech
   Ministry of Health; Cooperatio Program, research area DIAG given by
   Charles University, and the project National Institute for Research of
   Metabolic and Cardiovascular Diseases (Programme EXCELES LX22NPO5104)
   funded by the European Union-Next Generation EU.
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NR 40
TC 2
Z9 2
U1 0
U2 6
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD JUL
PY 2023
VL 24
IS 13
AR 10614
DI 10.3390/ijms241310614
PG 9
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA M8WN2
UT WOS:001032964000001
PM 37445792
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Heit, C
   Marshall, S
   Singh, S
   Yu, XQ
   Charkoftaki, G
   Zhao, HY
   Orlicky, DJ
   Fritz, KS
   Thompson, DC
   Vasiliou, V
AF Heit, Claire
   Marshall, Stephanie
   Singh, Surrendra
   Yu, Xiaoqing
   Charkoftaki, Georgia
   Zhao, Hongyu
   Orlicky, David J.
   Fritz, Kristofer S.
   Thompson, David C.
   Vasiliou, Vasilis
TI Catalase deletion promotes prediabetic phenotype in mice
SO FREE RADICAL BIOLOGY AND MEDICINE
LA English
DT Article
DE Catalase; Obesity; Metabolism; Steatosis; Diabetes
ID ADIPOSE-TISSUE DISTRIBUTION; INDUCED HEPATIC STEATOSIS; TYPE-2
   DIABETES-MELLITUS; INSULIN-RESISTANCE; HYDROGEN-PEROXIDE; OXIDATIVE
   STRESS; PPAR-GAMMA; GENE-EXPRESSION; BETA-CELLS; METABOLIC SYNDROME
AB Hydrogen peroxide is produced endogenously and can be toxic to living organisms by inducing oxidative stress and cell damage. However, it has also been identified as a signal transduction molecule. By metabolizing hydrogen peroxide, catalase protects cells and tissues against oxidative damage and may also influence signal transduction mechanisms. Studies suggest that acatalasemic individuals (ie., those with very low catalase activity) have a higher risk for the development of diabetes. We now report catalase knockout (Cat(-/-)) mice, when fed a normal (6.5% lipid) chow, exhibit an obese phenotype that manifests as an increase in body weight that becomes more pronounced with age. The mice demonstrate altered hepatic and muscle lipid deposition, as well as increases in serum and hepatic triglycerides (TGs), and increased hepatic transcription and protein expression of PPAR gamma. Liver morphology revealed steatosis with inflammation. Cat(-/-) mice also exhibited pancreatic morphological changes that correlated with impaired glucose tolerance and increased fasting serum insulin levels, conditions consistent with pre-diabetic status. RNA-seq analyses revealed a differential expression of pathways and genes in Cat(-/)- mice, many of which are related to metabolic syndrome, diabetes, and obesity, such as Pparg and Cidee.
   In conclusion, the results of the present study show mice devoid of catalase develop an obese, pre-diabetic phenotype and provide compelling evidence for catalase (or its products) being integral in metabolic regulation.
C1 [Heit, Claire; Fritz, Kristofer S.] Univ Colorado Denver, Sch Pharm, Dept Pharmaceut Sci, Anschutz Med Campus,12850 East Montview Blvd, Aurora, CO 80045 USA.
   [Marshall, Stephanie; Singh, Surrendra; Charkoftaki, Georgia; Vasiliou, Vasilis] Yale Univ, Yale Sch Publ Hlth, Dept Environm Hlth Serv, 60 Coll St, New Haven, CT 06520 USA.
   [Yu, Xiaoqing; Zhao, Hongyu] Yale Univ, Yale Sch Publ Hlth, Dept Biostat, New Haven, CT 06520 USA.
   [Orlicky, David J.] Univ Colorado, Sch Med, Dept Pathol, Anschutz Med Campus, Aurora, CO USA.
   [Thompson, David C.] Univ Colorado, Sch Pharm, Dept Clin Pharm, Anschutz Med Campus,12850 East Montview Blvd, Aurora, CO 80045 USA.
C3 Children's Hospital Colorado; University of Colorado System; University
   of Colorado Anschutz Medical Campus; Yale University; Yale University;
   University of Colorado System; University of Colorado Anschutz Medical
   Campus; University of Colorado System; University of Colorado Anschutz
   Medical Campus
RP Vasiliou, V (corresponding author), Yale Univ, Yale Sch Publ Hlth, Dept Environm Hlth Serv, 60 Coll St, New Haven, CT 06520 USA.
EM vasilis.vasiliou@yale.edu
RI Zhao, Hongyu/KTH-9411-2024; Charkoftaki, Georgia/AAI-6517-2020; Yu,
   Xiaoqing/E-2388-2013
OI Fritz, Kristofer/0000-0002-1499-6174; vasiliou,
   vasilis/0000-0003-2552-3118
FU NIH grants [AA022057, AA021724]; Cancer Center Support Grant
   [P30CA046934]; NIAAA [F32 FAA023699A]
FX We would like to thank Dr. Ying Chen of Yale School of Public Health and
   Peter Harris of University of Colorado Department of Pharmaceutical
   Science for their assistance, expertise and support with this project.
   This work is supported in part by NIH grants AA022057 (VV), AA021724
   (VV), Cancer Center Support Grant (P30CA046934). SM was supported by the
   NIAAA F32 FAA023699A.
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NR 71
TC 52
Z9 60
U1 2
U2 14
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0891-5849
EI 1873-4596
J9 FREE RADICAL BIO MED
JI Free Radic. Biol. Med.
PD FEB
PY 2017
VL 103
BP 48
EP 56
DI 10.1016/j.freeradbiomed.2016.12.011
PG 9
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA EJ2BJ
UT WOS:000393014600005
PM 27939935
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Peluso, I
   Manafikhi, H
   Reggi, R
   Palmery, M
AF Peluso, Ilaria
   Manafikhi, Husseen
   Reggi, Raffaella
   Palmery, Maura
TI Effects of red wine on postprandial stress: potential implication in
   non-alcoholic fatty liver disease development
SO EUROPEAN JOURNAL OF NUTRITION
LA English
DT Review
DE Postprandial stress; Red wine; Non-alcoholic fatty liver disease
ID FACTOR-KAPPA-B; PLASMA ANTIOXIDANT CAPACITY; OXYGEN SPECIES GENERATION;
   MODERATE ALCOHOL INTAKE; OXIDATIVE STRESS; ENDOTHELIAL FUNCTION;
   MONONUCLEAR-CELLS; MIXED MEAL; CONSUMPTION; INCREASE
AB Red wine consumption is considered to be protective against oxidative stress. Diet strongly influences non-alcoholic fatty liver disease, which is associated with oxidative stress and is considered the hepatic manifestation of the metabolic syndrome.
   We reviewed the available evidence that investigated the effects of red wine on the postprandial-induced metabolic and oxidative stress in humans.
   After red wine consumption with meal, despite the improvement in non-enzymatic antioxidant capacity and lipoperoxidation markers, the influence of confounding factors such as uric acid should be taken into account. Both uric acid and triglycerides increases, induced by ethanol, could cause liver damage. On the other hand, further researches are required in order to understand the meaning of the induction of antioxidant enzymes by red wine and red wine polyphenols in the context of non-alcoholic fatty liver disease.
   In conclusion, inconsistent and contrasting findings exist regarding the potential benefits of red wine consumption against postprandial stress.
C1 [Peluso, Ilaria] Agr Res Council CRA NUT, Ctr Food & Nutr, I-00178 Rome, Italy.
   [Manafikhi, Husseen; Reggi, Raffaella; Palmery, Maura] Univ Roma La Sapienza, Dept Physiol & Pharmacol V Erspamer, I-00185 Rome, Italy.
C3 Consiglio per la Ricerca in Agricoltura e L'analisi Dell'economia
   Agraria (CREA); Sapienza University Rome
RP Palmery, M (corresponding author), Univ Roma La Sapienza, Dept Physiol & Pharmacol V Erspamer, Ple Aldo Moro 5, I-00185 Rome, Italy.
EM physio_pharm@yahoo.it
RI Peluso, Ilaria/ABE-3399-2021; Peluso, Ilaria/A-8023-2018
OI Peluso, Ilaria/0000-0002-6210-5241
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NR 97
TC 10
Z9 10
U1 2
U2 25
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1436-6207
EI 1436-6215
J9 EUR J NUTR
JI Eur. J. Nutr.
PD JUN
PY 2015
VL 54
IS 4
BP 497
EP 507
DI 10.1007/s00394-015-0877-2
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA CI4KG
UT WOS:000354716500001
PM 25772634
DA 2025-06-11
ER

PT J
AU Wolk, R
   Shamsuzzaman, ASM
   Somers, VK
AF Wolk, R
   Shamsuzzaman, ASM
   Somers, VK
TI Obesity, sleep apnea, and hypertension
SO HYPERTENSION
LA English
DT Review
DE hypertension, obesity; sleep apnea syndromes; sympathetic nervous
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ID POSITIVE AIRWAY PRESSURE; C-REACTIVE PROTEIN; ENDOTHELIUM-DEPENDENT
   VASODILATION; SYMPATHETIC-NERVOUS-SYSTEM; INDEPENDENT RISK-FACTOR;
   BLOOD-PRESSURE; OXIDATIVE STRESS; CARDIOVASCULAR-DISEASE; METABOLIC
   SYNDROME; NEURAL MECHANISMS
AB Obesity has a high and rising prevalence and represents a major public health problem. Obstructive sleep apnea ( OSA) is also common, affecting an estimated 15 million Americans, with a prevalence that is probably also rising as a consequence of increasing obesity. Epidemiologic data support a link between obesity and hypertension as well as between OSA and hypertension. For example, untreated OSA predisposes to an increased risk of new hypertension, and treatment of OSA lowers blood pressure, even during the daytime. Possible mechanisms whereby OSA may contribute to hypertension in obese individuals include sympathetic activation, hyperleptinemia, insulin resistance, elevated angiotensin II and aldosterone levels, oxidative and inflammatory stress, endothelial dysfunction, impaired baroreflex function, and perhaps by effects on renal function. The coexistence of OSA and obesity may have more widespread implications for cardiovascular control and dysfunction in obese individuals and may contribute to some of the clustering of abnormalities broadly defined as the metabolic syndrome. From the clinical and therapeutic perspectives, the presence of resistant hypertension and the absence of a nocturnal decrease in blood pressure in obese individuals should prompt the clinician to consider the diagnosis of OSA, especially if clinical symptoms suggestive of OSA ( such as poor sleep quality, witnessed apnea, excessive daytime somnolence, and so forth) are also present.
C1 Mayo Clin, Rochester, MN USA.
C3 Mayo Clinic
RP St Marys Hosp, Mayo Fdn, DO-4-350,1216 2nd St SW, Rochester, MN 55902 USA.
EM somers.virend@mayo.edu
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NR 84
TC 354
Z9 407
U1 1
U2 29
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0194-911X
EI 1524-4563
J9 HYPERTENSION
JI Hypertension
PD DEC
PY 2003
VL 42
IS 6
BP 1067
EP 1074
DI 10.1161/01.HYP.0000101686.98973.A3
PG 8
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 752TR
UT WOS:000187183700001
PM 14610096
OA Bronze
DA 2025-06-11
ER

PT J
AU Foss, B
   Dyrstad, SM
AF Foss, Brynjar
   Dyrstad, Sindre M.
TI Stress in obesity: Cause or consequence?
SO MEDICAL HYPOTHESES
LA English
DT Article
ID PITUITARY-ADRENAL-AXIS; LOW-GRADE INFLAMMATION; METABOLIC SYNDROME;
   EATING BEHAVIOR; ABDOMINAL OBESITY; CORTISOL; WOMEN; PERSPECTIVE;
   ILLNESS; LEPTIN
AB Obesity is a global public health challenge that increases the risk of various diseases including type 2 diabetes mellitus, hypertension and cancer, and will in the future cause further increases in the incidence of chronic disease. Understanding the mechanisms of obesity is critical if we are to prevent and treat this pandemic challenge. Diet and physical activity have traditionally been the major tasks in preventing and treating obesity. However, other mechanisms are now also being considered in the quest for knowledge and understanding of obesity, including the body's stress system and cortisol release. While it seems evident that stress is a cause of obesity, whether stress is also a consequence of obesity has up to now only briefly been discussed. The aim of this article is to elucidate how stress and obesity might be linked and discuss the cause/consequence relationship between the stress response and obesity. Our hypothesis is that stress and obesity interfere by positive feedback. This may be an important issue in both our understanding and coping of obesity. (C) 2011 Elsevier Ltd. All rights reserved.
C1 [Foss, Brynjar] Univ Stavanger, Dept Hlth Studies, N-4036 Stavanger, Norway.
   [Dyrstad, Sindre M.] Univ Stavanger, Dept Educ, N-4036 Stavanger, Norway.
C3 Universitetet i Stavanger; Universitetet i Stavanger
RP Foss, B (corresponding author), Univ Stavanger, Dept Hlth Studies, N-4036 Stavanger, Norway.
EM brynjar.foss@uis.no
RI Dyrstad, Sindre/HLX-1452-2023
OI Foss, Brynjar/0000-0002-3182-4497; Dyrstad, Sindre
   M./0000-0002-7862-2657
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NR 31
TC 87
Z9 109
U1 1
U2 65
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0306-9877
J9 MED HYPOTHESES
JI Med. Hypotheses
PD JUL
PY 2011
VL 77
IS 1
BP 7
EP 10
DI 10.1016/j.mehy.2011.03.011
PG 4
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 788FM
UT WOS:000292430800004
PM 21444159
DA 2025-06-11
ER

PT J
AU Li, A
   Tang, Z
   Zhu, PJ
   van den Bosch, F
   Chen, YT
   Xu, SL
   Tjakkes, GHE
AF Li, An
   Tang, Zhi
   Zhu, Peijun
   van den Bosch, Florien
   Chen, Yuntao
   Xu, Shulan
   Tjakkes, Geerten-Has E.
TI Serum Antioxidant Vitamins Mediate the Association between Periodontitis
   and Metabolically Unhealthy Overweight/Obesity
SO NUTRIENTS
LA English
DT Article
DE metabolic syndrome; overweight and obesity; periodontitis; serum
   antioxidants; systemic inflammation
ID ADIPOSE-TISSUE; OXIDATIVE STRESS; HEALTHY OBESE; INFLAMMATION; RISK;
   POPULATION; PREVALENCE; CONSEQUENCES; THERAPY; DISEASE
AB Background: Periodontal disease is associated with metabolic syndrome and obesity. This cross-sectional study aimed to investigate whether serum antioxidant vitamins could mediate the association between periodontitis and a metabolically unhealthy phenotype in the overweight and obese population; Methods: We included 6158 Americans (body mass index (BMI) >= 25 kg/m(2)) from the Third National Health and Nutrition Examination Survey (NHANES III). Periodontitis was defined using a half-reduced CDC/AAP (Centers for Disease Control and Prevention/American Academy of Periodontology) definition. Having two or more metabolic abnormalities was defined as a metabolically unhealthy overweight and obese (MUO) phenotype. Mediation analysis of four oxidative stress biomarkers (serum antioxidant vitamins A, C, D, and E) was conducted; Results: Of participants with overweight and obesity, 2052 (33.3%) Americans were categorized as having periodontitis. Periodontitis increased dyslipidemia risk and systemic inflammation in the overweight and obese population. In the multivariable logistic regression model, periodontitis was positively associated with MUO (adjusted odds ratio = 1.238; 95% confidence interval: 1.091 to 1.406). These findings were validated in an independent cohort. Serum vitamins C and D were estimated to mediate 19.3% and 8.4% of the periodontitis-MUO association. Conclusions: Periodontitis might decrease serum vitamins C and D and induce a metabolically unhealthy state among adults with overweight and obesity.
C1 [Li, An; Zhu, Peijun; Xu, Shulan] Southern Med Univ, Stomatol Hosp, Ctr Oral Implantol, Guangzhou 510280, Peoples R China.
   [Li, An; van den Bosch, Florien; Tjakkes, Geerten-Has E.] Univ Groningen, Univ Med Ctr Groningen UMCG, Ctr Dent & Oral Hyg, Dept Periodontol, NL-9713 AV Groningen, Netherlands.
   [Tang, Zhi] Southern Med Univ, Zhujiang Hosp, Dept Stomatol, Guangzhou 510280, Peoples R China.
   [Chen, Yuntao] UCL, Dept Epidemiol & Publ Hlth, London WC1E 6BT, England.
   [Chen, Yuntao] Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, Med Stat & Decis Making, NL-9713 AV Groningen, Netherlands.
C3 Southern Medical University - China; University of Groningen; Southern
   Medical University - China; University of London; University College
   London; University of Groningen
RP Xu, SL (corresponding author), Southern Med Univ, Stomatol Hosp, Ctr Oral Implantol, Guangzhou 510280, Peoples R China.
EM xushulan_672588@smu.edu.cn
RI Li, An/AAW-8494-2021; Xu, shulan/GZM-8844-2022
OI Li, An/0000-0001-5750-526X; Chen, Simon/0000-0002-2536-3524
FU Science Research Cultivation Program of Stomatological Hospital,
   Southern Medical University, China [PY2021007]; Clinical Research
   Initiation Plan of Stomatological Hospital, Southern Medical University,
   China [KQIIT2021001]
FX This research was funded by the Science Research Cultivation Program of
   Stomatological Hospital, Southern Medical University, China (No.
   PY2021007) and the Clinical Research Initiation Plan of Stomatological
   Hospital, Southern Medical University, China (No. KQIIT2021001).
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NR 64
TC 5
Z9 6
U1 3
U2 13
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD NOV
PY 2022
VL 14
IS 22
AR 4939
DI 10.3390/nu14224939
PG 15
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 6K8OE
UT WOS:000887753300001
PM 36432625
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Pattnaik, B
   Bodas, M
   Bhatraju, NK
   Ahmad, T
   Pant, R
   Guleria, R
   Ghosh, B
   Agrawal, A
AF Pattnaik, Bijay
   Bodas, Manish
   Bhatraju, Naveen Kumar
   Ahmad, Tanveer
   Pant, Richa
   Guleria, Randeep
   Ghosh, Balaram
   Agrawal, Anurag
TI IL-4 promotes asymmetric dimethylarginine accumulation, oxo-nitrative
   stress, and hypoxic response-induced mitochondrial loss in airway
   epithelial cells
SO JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
LA English
DT Article
DE IL-4; ADMA; hypoxic response; mitochondrial transcription factor A;
   mitochondria
ID TRANSCRIPTION FACTOR-A; METABOLIC SYNDROME; ARGININE METABOLISM; COPY
   NUMBER; ASTHMA; INFLAMMATION; EXPRESSION; MODEL
AB Background: Obesity is known to increase asthma risk and severity. Increased levels of asymmetric dimethylarginine (ADMA), an endogenous nitric oxide synthase inhibitor, are associated with mitochondrial toxicity, asthma, and metabolic syndrome. IL-4 upregulates the expression of protein arginine methyltransferases, which are essential for ADMA formation. Importantly, cross-talk between IL-4, ADMA, and mitochondrial dysfunction could explain how obesity and IL-4 can synergize to exacerbate allergic inflammation.
   Objective: We sought to investigate how IL-4, a key asthma-associated cytokine, can influenceADMA-related effects on lungs.
   Methods: BEAS2B (bronchial epithelial) cells were treated with IL-4 followed by ADMA and investigated for oxo-nitrative stress and resultant mitochondrial toxicity after 48 hours by using flow cytometry, confocal imaging, immunoblotting, and fluorimetric assays.
   Results: IL-4-induced mitotoxicity in BEAS2B cells was significantly higher in the presence of exogenous ADMA. IL-4 treatment led to proteolytic degradation of dimethylarginine dimethylaminohydrolase 2, which catabolizes ADMA. IL-4 pretreatment was associated with increased intracellular ADMA accumulation and increased ADMA-induced mitotoxicity. Airway epithelial cells treated with IL-4 followed by ADMA showed exaggerated oxo-nitrative stress and potent induction of the cellular hypoxic response, despite normoxic conditions. The hypoxic response was associated with reduced mitochondrial function but was reversible by overexpression of the mitochondrial biogenesis factor, mitochondrial transcription factor A.
   Conclusion: We conclude that IL-4 promotes intracellular ADMA accumulation, leading to mitochondrial loss through oxo-nitrative stress and hypoxic response. This provides a novel understanding of how obesity, with high ADMA levels, and asthma, with high IL-4 levels, might potentiate each other and highlights the potential of mitochondrial-targeted therapeutics in obese subjects with asthma.
C1 [Pattnaik, Bijay; Bodas, Manish; Bhatraju, Naveen Kumar; Ahmad, Tanveer; Pant, Richa; Ghosh, Balaram; Agrawal, Anurag] CSIR, Inst Genom & Integrat Biol, Immunogenet Mol Lab, Mall Rd, Delhi 110007, India.
   [Pattnaik, Bijay; Bodas, Manish; Bhatraju, Naveen Kumar; Ahmad, Tanveer; Pant, Richa; Ghosh, Balaram; Agrawal, Anurag] CSIR, Inst Genom & Integrat Biol, Ctr Excellence Translat Res Asthma & Lung Dis, Delhi, India.
   [Guleria, Randeep] All India Inst Med Sci, Dept Pulm Med & Sleep Disorders, New Delhi, India.
C3 Council of Scientific & Industrial Research (CSIR) - India; CSIR -
   Institute of Genomics & Integrative Biology (IGIB); Council of
   Scientific & Industrial Research (CSIR) - India; CSIR - Institute of
   Genomics & Integrative Biology (IGIB); All India Institute of Medical
   Sciences (AIIMS) New Delhi
RP Agrawal, A (corresponding author), CSIR, Inst Genom & Integrat Biol, Immunogenet Mol Lab, Mall Rd, Delhi 110007, India.
EM a.agrawal@igib.in
RI Agrawal, Anurag/GZL-5821-2022; Bodas, Manish/AAE-4016-2020; Pattnaik,
   Bijay Ranjan/GOK-0878-2022
OI Bhatraju, Naveen Kumar/0000-0002-6248-7956; Pattnaik,
   Bijay/0000-0003-3534-7410; Agrawal, Anurag/0000-0002-0340-5252; Ahmad,
   Tanveer/0000-0002-8384-5273; BODAS, MANISH/0000-0002-1046-9799
FU Council of Scientific and Industrial Research (CSIR), India [MLP 5502,
   BSC 0116, MLP 1201]; Swarnajayanti Fellowship; Department of Science and
   Technology (DST), India; Department of Science and Technology,
   Government of India [GAP 0069]; Council of Scientific and Industrial
   Research, Government of India [MLP 5502, BSC 0116]
FX Supported by grants from the Council of Scientific and Industrial
   Research (CSIR), India (MLP 5502, BSC 0116, and MLP 1201); the
   Swarnajayanti Fellowship; and the Department of Science and Technology
   (DST), India. Research was supported by grant GAP 0069 (Swarnajayanti
   Project) from the Department of Science and Technology, Government of
   India, and grant MLP 5502 and BSC 0116 from the Council of Scientific
   and Industrial Research, Government of India.
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NR 46
TC 32
Z9 33
U1 0
U2 15
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0091-6749
EI 1097-6825
J9 J ALLERGY CLIN IMMUN
JI J. Allergy Clin. Immunol.
PD JUL
PY 2016
VL 138
IS 1
BP 130
EP +
DI 10.1016/j.jaci.2015.11.036
PG 21
WC Allergy; Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Allergy; Immunology
GA DR1IL
UT WOS:000379659100015
PM 26915676
DA 2025-06-11
ER

PT J
AU Singh, U
   Devaraj, S
   Jialal, I
   Siegel, D
AF Singh, Uma
   Devaraj, Sridevi
   Jialal, Ishwarlal
   Siegel, David
TI Comparison effect of atorvastatin (10 versus 80 mg) on biomarkers of
   inflammation and oxidative stress in subjects with metabolic syndrome
SO AMERICAN JOURNAL OF CARDIOLOGY
LA English
DT Article
ID C-REACTIVE PROTEIN; ACUTE CORONARY SYNDROMES; MYOCARDIAL-INFARCTION;
   UNSTABLE ANGINA; ELEVATED LEVELS; ARTERY-DISEASE; ACTIVATION; STATINS;
   MATRIX-METALLOPROTEINASE-9; SIMVASTATIN
AB Metabolic syndrome (MS), characterized by low-grade inflammation, confers an increased risk for cardiovascular disease. Statins, in addition to having lipid-lowering effects, have pleiotropic effects and decrease biomarkers of inflammation and oxidative stress. The Treating to New Target Study showed a greater decrease in low-density lipoprotein (LDL) cholesterol and cardiovascular events with atorvastatin 80 mg versus 10 mg in patients with MS with coronary heart disease. However, part of this benefit could be caused by the greater pleiotropic effects of the higher dose of atorvastatin. The dose-response effect of atorvastatin on biomarkers of inflammation and oxidative stress has not been investigated in subjects with MS. Thus, the dose-response effect of atorvastatin on biomarkers of inflammation (high-sensitivity C-reactive protein [hs-CRP], matrix metalloproteinase-9, and nuclear factor-kappa B [NF-kB] activity) and oxidative stress (oxidized LDL, urinary nitrotyrosine, F2-isoprostanes, and monocyte superoxide release) was tested in a randomized double-blind clinical trial in subjects with MS. Seventy subjects were randomly assigned to receive placebo or atorvastatin 10 or 80 mg/day for 12 weeks. A strong dose-response (atorvastatin 10 compared with 80 mg, p <0.05) was observed for changes in total, LDL (32% and 44% reduction), non-high-density lipoprotein (28% and 40% reduction), and oxidized LDL cholesterol (24% and 39% reduction) at atorvastatin 10 and 80 mg, respectively. Hs-CRP, matrix metalloproteinase-9, and NF-kB significantly decreased in the 80-mg atorvastatin group compared with baseline. In conclusion, this randomized trial of subjects with MS showed the superiority of atorvastatin 80 mg compared with its 10-mg dose in decreasing oxidized LDL, hs-CRP, matrix metalloproteinase-9, and NF-kB activity. (C) 2008 Elsevier Inc. All rights reserved.
C1 [Singh, Uma; Devaraj, Sridevi; Jialal, Ishwarlal; Siegel, David] Univ Calif Davis, Med Ctr, Dept Pathol & Lab Med, Lab Atherosclerosis & Metab Res, Sacramento, CA 95817 USA.
C3 University of California System; University of California Davis
RP Jialal, I (corresponding author), Univ Calif Davis, Med Ctr, Dept Pathol & Lab Med, Lab Atherosclerosis & Metab Res, Sacramento, CA 95817 USA.
EM ishwarlal.jialal@ucdmc.ucdavis.edu
RI Jialal, Ishwarlal/AAG-6218-2019
FU NCCIH NIH HHS [K24 AT000596, K24 AT00596] Funding Source: Medline
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NR 30
TC 67
Z9 76
U1 0
U2 0
PU EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
PI BRIDGEWATER
PA 685 ROUTE 202-206 STE 3, BRIDGEWATER, NJ 08807 USA
SN 0002-9149
EI 1879-1913
J9 AM J CARDIOL
JI Am. J. Cardiol.
PD AUG 1
PY 2008
VL 102
IS 3
BP 321
EP 325
DI 10.1016/j.amjcard.2008.03.057
PG 5
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 331LD
UT WOS:000258012800013
PM 18638594
OA Green Accepted
DA 2025-06-11
ER

PT S
AU Han, J
   Kaufman, RJ
AF Han, Jaeseok
   Kaufman, Randal J.
BE MacDougald, OA
TI Measurement of the Unfolded Protein Response to Investigate Its Role in
   Adipogenesis and Obesity
SO METHODS OF ADIPOSE TISSUE BIOLOGY, PT B
SE Methods in Enzymology
LA English
DT Review; Book Chapter
ID ENDOPLASMIC-RETICULUM STRESS; ER-STRESS; ADIPOSE-TISSUE;
   GENE-EXPRESSION; ATF6; PHOSPHORYLATION; PROTEOLYSIS; RESISTANCE;
   APOPTOSIS; IMPACT
AB The endoplasmic reticulum (ER) is the cellular organelle responsible for the folding of proteins destined for secretion and the intramembrane system of the cell, biosynthesis of lipids, and storage of calcium for regulated release. Extracellular stimuli and changes in intracellular homeostasis can alter the protein-folding environment of the ER and cause the accumulation of misfolded or unfolded proteins, a stress condition called ER stress. To resolve protein misfolding, cells have evolved a collection of adaptive signaling pathways, called the unfolded protein response (UPR). It is now recognized that ER stress contributes to many pathophysiological conditions. Increasing lines of evidence suggest that obesity/insulin resistance and subsequent type 2 diabetes are associated with ER stress and UPR activation in adipose tissue. However, whether and/or how ER stress and the UPR contribute to the pathogenesis of metabolic syndrome and obesity is not entirely clear. In this section, we describe how the UPR may contribute to the pathology of obesity, methods to measure UPR induction, and approaches to investigate the role of the UPR during adipocyte differentiation and in mature adipose tissue.
C1 [Han, Jaeseok; Kaufman, Randal J.] Sanford Burnham Med Res Inst, Ctr Neurosci Aging & Stem Cell Res, La Jolla, CA USA.
C3 Sanford Burnham Prebys Medical Discovery Institute
RP Kaufman, RJ (corresponding author), Sanford Burnham Med Res Inst, Ctr Neurosci Aging & Stem Cell Res, La Jolla, CA USA.
EM rkaufman@sanfordburnham.org
RI Han, Jaeseok/AAE-6872-2020; Kaufman, Randal/LGY-4753-2024
FU NHLBI NIH HHS [HL052173, HL057346] Funding Source: Medline; NIDDK NIH
   HHS [DK088227, DK042394] Funding Source: Medline
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NR 36
TC 9
Z9 10
U1 0
U2 10
PU ELSEVIER ACADEMIC PRESS INC
PI SAN DIEGO
PA 525 B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0076-6879
BN 978-0-12-800280-3
J9 METHOD ENZYMOL
JI Methods Enzymol.
PY 2014
VL 538
BP 135
EP 150
DI 10.1016/B978-0-12-800280-3.00008-6
PG 16
WC Biochemical Research Methods; Biochemistry & Molecular Biology; Cell
   Biology
WE Book Citation Index – Science (BKCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA BA2GT
UT WOS:000333378700008
PM 24529437
DA 2025-06-11
ER

PT J
AU Xie, ZX
   Xia, SF
   Qiao, Y
   Shi, YH
   Le, GW
AF Xie, Z. X.
   Xia, S. F.
   Qiao, Y.
   Shi, Y. H.
   Le, G. W.
TI Effect of GABA on oxidative stress in the skeletal muscles and plasma
   free amino acids in mice fed high-fat diet
SO JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION
LA English
DT Article
DE metabolic syndrome; obesity; oxidative stress; protein oxidation;
   gamma-aminobutyric acid; plasma free amino acid
ID INSULIN-RESISTANCE; DIABETES-MELLITUS; NONNEURAL TISSUES; OBESITY;
   METABOLISM; TARGET; RAT; RECEPTORS; LEUCINE; HUMANS
AB Increased levels of plasma free amino acids (pFAAs) can disturb the blood glucose levels in patients with obesity, diabetes mellitus and metabolic syndrome (MS) and are associated with enhanced protein oxidation. Oxidation of proteins, especially in the muscles, can promote protein degradation and elevate the levels of pFAAs. Gamma-aminobutyric acid (GABA), a food additive, can reduce high-fat diet (HFD)-induced hyperglycaemia; however, the mechanisms remain unclear. The aim of this study was to evaluate the effects of GABA on protein oxidation and pFAAs changes. One hundred male C57BL/6 mice were randomly divided into five groups that were fed with control diet, HFD and HFD supplied with 0.2%, 0.12% and 0.06% GABA in drinking water for 20weeks respectively. HFD feeding led to muscular oxidative stress, protein oxidation, pFAA disorders, hyperglycaemia and augmented plasma GABA levels. Treatment with GABA restored normally fasting blood glucose level and dose-dependently inhibited body weight gains, muscular oxidation and protein degradation. While medium and low doses of GABA mitigated HFD-induced pFAA disorders, the high dose of GABA deteriorated the pFAA disorders. Medium dose of GABA increased the levels of GABA, but high dose of GABA reduced the levels of plasma GABA and increased the activity of succinic semialdehyde dehydrogenase in the liver. Therefore, treatment with GABA mitigated HFD-induced hyperglycaemia probably by repairing HFD-induced muscular oxidative stress and pFAA disorders in mice. Our data also suggest that an optimal dose of GABA is crucial for the prevention of excess GABA-related decrease in the levels of pFAA and GABA as well as obesity.
C1 [Xie, Z. X.; Xia, S. F.; Qiao, Y.; Shi, Y. H.; Le, G. W.] Jiangnan Univ, Sch Food Sci & Technol, State Key Lab Food Sci & Technol, Wuxi 214122, Peoples R China.
C3 Jiangnan University
RP Le, GW (corresponding author), Jiangnan Univ, Sch Food Sci & Technol, State Key Lab Food Sci & Technol, Wuxi 214122, Peoples R China.
EM lgw@jiangnan.edu.cn
RI SHI, YH/HLG-1159-2023
FU 12th Five-year Plan for Science and Technology Development [2012BAD
   33B05]
FX This work was supported by 12th Five-year Plan for Science and
   Technology Development (No. 2012BAD 33B05).
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NR 40
TC 35
Z9 39
U1 2
U2 48
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0931-2439
EI 1439-0396
J9 J ANIM PHYSIOL AN N
JI J. Anim. Physiol. Anim. Nutr.
PD JUN
PY 2015
VL 99
IS 3
BP 492
EP 500
DI 10.1111/jpn.12254
PG 9
WC Agriculture, Dairy & Animal Science; Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture; Veterinary Sciences
GA CG5UD
UT WOS:000353360500012
PM 25266692
DA 2025-06-11
ER

PT J
AU Ehx, G
   Gérin, S
   Mathy, G
   Franck, F
   Oliveira, HC
   Vercesi, AE
   Sluse, FE
AF Ehx, Gregory
   Gerin, Stephanie
   Mathy, Gregory
   Franck, Fabrice
   Oliveira, Helena C. F.
   Vercesi, Anibal E.
   Sluse, Francis E.
TI Liver proteomic response to hypertriglyceridemia in human-apolipoprotein
   C-III transgenic mice at cellular and mitochondrial compartment levels
SO LIPIDS IN HEALTH AND DISEASE
LA English
DT Article
ID TRIGLYCERIDE-RICH LIPOPROTEINS; IN-GEL ELECTROPHORESIS; FERRITIN
   MESSENGER-RNA; NONALCOHOLIC STEATOHEPATITIS; OXIDATIVE STRESS; APO-CIII;
   METABOLIC SYNDROME; FATTY LIVER; IRON; TRANSPORT
AB Background: Hypertriglyceridemia (HTG) is defined as a triglyceride (TG) plasma level exceeding 150 mg/dl and is tightly associated with atherosclerosis, metabolic syndrome, obesity, diabetes and acute pancreatitis. The present study was undertaken to investigate the mitochondrial, sub-mitochondrial and cellular proteomic impact of hypertriglyceridemia in the hepatocytes of hypertriglyceridemic transgenic mice (overexpressing the human apolipoproteinC-III).
   Methods: Quantitative proteomics (2D-DIGE) analysis was carried out on both "low-expressor" (LE) and "high-expressor" (HE) mice, respectively exhibiting moderate and severe HTG, to characterize the effect of the TG plasma level on the proteomic response.
   Results: The mitoproteome analysis has revealed a large-scale phenomenon in transgenic mice, i.e. a general down-regulation of matricial proteins and up-regulation of inner membrane proteins. These data also demonstrate that the magnitude of proteomic changes strongly depends on the TG plasma level. Our different analyses indicate that, in HE mice, the capacity of several metabolic pathways is altered to promote the availability of acetyl-CoA, glycerol-3-phosphate, ATP and NADPH for TG de novo biosynthesis. The up-regulation of several cytosolic ROS detoxifying enzymes has also been observed, suggesting that the cytoplasm of HTG mice is subjected to oxidative stress. Moreover, our results suggest that iron over-accumulation takes place in the cytosol of HE mice hepatocytes and may contribute to enhance oxidative stress and to promote cellular proliferation.
   Conclusions: These results indicate that the metabolic response to HTG in human apolipoprotein C-III overexpressing mice may support a high TG production rate and that the cytosol of hepatocytes is subjected to an important oxidative stress, probably as a result of FFA over-accumulation, iron overload and enhanced activity of some ROS-producing catabolic enzymes.
C1 [Ehx, Gregory; Gerin, Stephanie; Mathy, Gregory; Franck, Fabrice; Sluse, Francis E.] Univ Liege, Dept Life Sci, Lab Bioenerget B22, B-4000 Liege, Belgium.
   [Oliveira, Helena C. F.] Univ Estadual Campinas, Inst Biol, Dept Fisiol & Biofis, BR-13083887 Campinas, SP, Brazil.
   [Vercesi, Anibal E.] Univ Estadual Campinas UNICAMP, Fac Ciencias Med, Dept Patol Clin, BR-13083 Sao Paulo, Brazil.
C3 University of Liege; Universidade Estadual de Campinas; Universidade de
   Sao Paulo; Universidade Estadual de Campinas
RP Sluse, FE (corresponding author), Univ Liege, Dept Life Sci, Lab Bioenerget B22, Blvd rectorat 27, B-4000 Liege, Belgium.
EM f.sluse@ulg.ac.be
RI Vercesi, Aníbal/C-8767-2012; Oliveira, Helena/C-1343-2013; Ehx,
   Gregory/AAH-1706-2021
OI Oliveira, Helena/0000-0003-0119-6992; Ehx, Gregory/0000-0002-7018-1770;
   Vercesi, Anibal Eugenio/0000-0001-6671-7125
FU Fond de la Recherche Fondamentale et Collective grant [FRFC 2.4597.11];
   Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
   [2011/50400-0]; FRS-FNRS
FX This work was supported by a Fond de la Recherche Fondamentale et
   Collective grant (FRFC 2.4597.11) and by the Fundacao de Amparo a
   Pesquisa do Estado de Sao Paulo (FAPESP) - grant #2011/50400-0. GE and
   SG are recipients of FRS-FNRS doctoral fellowships. FF is a Research
   Director of the FRS-FNRS. We would like to thank Dr. Luciane Alberici
   for providing us with biological samples and Dr. Pierre Leprince and
   Prof. Edwin de Pauw for providing us with access to proteomic and mass
   spectrometry platforms.
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NR 56
TC 8
Z9 9
U1 2
U2 6
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1476-511X
J9 LIPIDS HEALTH DIS
JI Lipids Health Dis.
PD JUL 21
PY 2014
VL 13
AR 116
DI 10.1186/1476-511X-13-116
PG 16
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA AM0DF
UT WOS:000339512800001
PM 25047818
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Pajer, KA
AF Pajer, Kathleen A.
TI Cardiovascular disease risk factors in adolescents: do negative emotions
   and hypothalamic-pituitary-adrenal axis function play a role?
SO CURRENT OPINION IN PEDIATRICS
LA English
DT Review
DE adolescents; cardiovascular disease risk; depression; hostility/anger;
   hypothalamic-pituitary-adrenal axis
ID CORONARY-HEART-DISEASE; C-REACTIVE PROTEIN; SALIVARY CORTISOL;
   DEPRESSIVE SYMPTOMS; CONDUCT DISORDER; ARTERY-DISEASE; METABOLIC
   SYNDROME; MAJOR DEPRESSION; HYPERCORTISOLEMIC DEPRESSION;
   PROINFLAMMATORY CYTOKINES
AB Purpose of review Negative emotions such as depression and hostility/anger are important risk factors for cardiovascular disease in adults, but are often neglected in treatment or prevention programs. Adolescence is a stage of life when negative emotions often first become problematic and is also a time when the pathogenesis of cardiovascular disease appears I to accelerate. The literature on negative emotions and cardiovascular disease risk factors in adolescents is reviewed here.
   Recent findings Research indicates that negative emotions are associated with cardiovascular disease risk factors in adolescence. Negative emotions are also associated with several types of hypothalamic-pituitary-adrenal axis dysregulation. Such dysregulation appears to have a facilitatory effect on cardiovascular disease development and progression in adults. Thus, it is possible that negative emotions in adolescents may be risk factors for the development of cardiovascular disease via dysiregulation of the hypothalamic-pituitary-adrenal axis. Although this hypothesis has not been directly tested, some studies indirectly support the hypothesis.
   Summary Negative emotions are associated with cardiovascular disease risk factors in adolescents; it is possible that hypothalamic-pituitary-adrenal axis dysiregulation is an important mechanism. This hypothesis merits further research, If the hypothesis is valid, it has significant implications for early prevention of cardiovascular disease.
C1 Ohio State Univ, Coll Med, Columbus Childrens Res Inst, Dept Pediat, Columbus, OH 43210 USA.
C3 University System of Ohio; Ohio State University
RP Pajer, KA (corresponding author), Ohio State Univ, Coll Med, Columbus Childrens Res Inst, Dept Pediat, Timken Hall G354,700 Childrens Dr, Columbus, OH 43205 USA.
EM pajerk@pediatrics.ohio-state.edu
FU NIMH NIH HHS [R01 MH 066003] Funding Source: Medline
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PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1040-8703
J9 CURR OPIN PEDIATR
JI CURR. OPIN. PEDIATR.
PD OCT
PY 2007
VL 19
IS 5
BP 559
EP 564
DI 10.1097/MOP.0b013e3282ef443a
PG 6
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Pediatrics
GA 217HG
UT WOS:000249938400006
PM 17885475
DA 2025-06-11
ER

PT J
AU Hurtado-Roca, Y
   Bueno, H
   Fernandez-Ortiz, A
   Ordovas, JM
   Ibañez, B
   Fuster, V
   Rodriguez-Artalejo, F
   Laclaustra, M
AF Hurtado-Roca, Yamilee
   Bueno, Hector
   Fernandez-Ortiz, Antonio
   Maria Ordovas, Jose
   Ibanez, Borja
   Fuster, Valentin
   Rodriguez-Artalejo, Fernando
   Laclaustra, Martin
TI Oxidized LDL Is Associated With Metabolic Syndrome Traits Independently
   of Central Obesity and Insulin Resistance
SO DIABETES
LA English
DT Article
ID LOW-DENSITY-LIPOPROTEIN; ACTIVATED SIGNALING PATHWAYS; OXIDATIVE STRESS
   MARKERS; SUBCLINICAL ATHEROSCLEROSIS; CARDIOVASCULAR-DISEASE;
   ANTIOXIDANT ENZYMES; PLASMA-GLUCOSE; RISK; MECHANISMS; BIOMARKERS
AB This study assesses whether oxidative stress, using oxidized LDL (ox-LDL) as a proxy, is associated with metabolic syndrome (MS), whether ox-LDL mediates the association between central obesity and MS, and whether insulin resistance mediates the association between ox-LDL and MS. We examined baseline data from 3,987 subjects without diabetes in the Progression of Early Subclinical Atherosclerosis (PESA) Study. For the second, third, and fourth ox-LDL quartiles versus the first, the odds ratios (95% CI) for MS were 0.84 (0.52, 1.36), 1.47 (0.95, 2.32), and 2.57 (1.66, 4.04) (P < 0.001 for trend) once adjusted for age, sex, smoking, LDL-cholesterol, BMI, waist circumference, and HOMA-insulin resistance (HOMA-IR). Results showing the same trend were found for all MS components except glucose concentration. Ox-LDL mediated 13.9% of the association of waist circumference with triglycerides and only 1-3% of the association with HDL-cholesterol, blood pressure, and insulin concentration. HOMA-IR did not mediate the association between ox-LDL and MS components. This study found higher ox-LDL concentrations were associated with MS and its components independently of central obesity and insulin resistance. Ox-LDL may reflect core mechanisms through which MS components develop and progress in parallel with insulin resistance and could be a clinically relevant predictor of MS development.
C1 [Hurtado-Roca, Yamilee; Bueno, Hector; Fernandez-Ortiz, Antonio; Maria Ordovas, Jose; Ibanez, Borja; Fuster, Valentin; Laclaustra, Martin] Ctr Nacl Invest Cardiovasc Carlos III, Madrid, Spain.
   [Hurtado-Roca, Yamilee; Rodriguez-Artalejo, Fernando; Laclaustra, Martin] Univ Autonoma Madrid Idipaz, Ctr Invest Biomed Red Epidemiol & Salud Publ, Madrid, Spain.
   [Hurtado-Roca, Yamilee; Rodriguez-Artalejo, Fernando; Laclaustra, Martin] Univ Autonoma Madrid Idipaz, Sch Med, Dept Prevent Med & Publ Hlth, Madrid, Spain.
   [Hurtado-Roca, Yamilee] Boca Raton Clin Res Global Peru, Lima, Peru.
   [Bueno, Hector] Hosp 12 Octubre, Madrid, Spain.
   [Fernandez-Ortiz, Antonio] Univ Complutense, Hosp Clin San Carlos, Madrid, Spain.
   [Maria Ordovas, Jose] Tufts Univ, USDA, Human Nutr Res Ctr Aging, Boston, MA 02111 USA.
   [Ibanez, Borja] Univ Autonoma Madrid, Inst Invest, Fdn Jimenez Diaz Hosp, Madrid, Spain.
   [Fuster, Valentin] Icahn Sch Med Mt Sinai, New York, NY 10029 USA.
   [Laclaustra, Martin] St Louis Univ, Dept Epidemiol, St Louis, MO 63103 USA.
C3 Centro Nacional de Investigaciones Cardiovasculares (CNIC); CIBER -
   Centro de Investigacion Biomedica en Red; CIBERESP; Hospital
   Universitario 12 de Octubre; Hospital Clinico San Carlos; Complutense
   University of Madrid; United States Department of Agriculture (USDA);
   Tufts University; Autonomous University of Madrid; Icahn School of
   Medicine at Mount Sinai; Saint Louis University
RP Laclaustra, M (corresponding author), Ctr Nacl Invest Cardiovasc Carlos III, Madrid, Spain.; Laclaustra, M (corresponding author), Univ Autonoma Madrid Idipaz, Ctr Invest Biomed Red Epidemiol & Salud Publ, Madrid, Spain.; Laclaustra, M (corresponding author), Univ Autonoma Madrid Idipaz, Sch Med, Dept Prevent Med & Publ Hlth, Madrid, Spain.; Laclaustra, M (corresponding author), St Louis Univ, Dept Epidemiol, St Louis, MO 63103 USA.
EM martin.laclaustra@uam.es
RI Fuster, Valentin/H-4319-2015; Laclaustra, Martin/C-6709-2015;
   Fernandez-Ortiz, Antonio/B-2227-2017; Ibanez, Borja/J-6993-2014; BUENO,
   HECTOR/I-3910-2015
OI Fuster, Valentin/0000-0002-9043-9986; Laclaustra,
   Martin/0000-0003-3963-0846; HURTADO-ROCA, YAMILEE/0000-0003-1993-6223;
   Fernandez-Ortiz, Antonio/0000-0002-3239-1910; Ibanez,
   Borja/0000-0002-5036-254X; BUENO, HECTOR/0000-0003-0277-7596
FU Republic of Peru and the Inter-American Development Bank through FINCyT
   Science and Technology Program Scholarships [088-FINCyT-BDE-2014,
   1663/OC-PE]; Institute de Salud Carlos III; European Regional
   Development Fund/European Social Fund, "Investing in Your Future"
   [PI10/00021, PI14/00009]; CNIC and Santander Bank; Spanish Ministry of
   Economy and Competitiveness (MINECO); Pro-CNIC Foundation and is a
   Severo Ochoa Center of Excellence (MINECO) [SEV-2015-0505]
FX Y.H.-R. received support from Republic of Peru and the Inter-American
   Development Bank through FINCyT Science and Technology Program
   Scholarships No. 088-FINCyT-BDE-2014 under agreement 1663/OC-PE. M.L.
   received partial support from the Institute de Salud Carlos III,
   cofunded by the European Regional Development Fund/European Social Fund,
   "Investing in Your Future" grants PI10/00021 and PI14/00009. The PESA
   study is supported by a noncompetitive unrestricted grant shared between
   the CNIC and Santander Bank. The CNIC is supported by the Spanish
   Ministry of Economy and Competitiveness (MINECO) and the Pro-CNIC
   Foundation and is a Severo Ochoa Center of Excellence (MINECO award
   SEV-2015-0505).
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NR 53
TC 43
Z9 45
U1 0
U2 19
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0012-1797
EI 1939-327X
J9 DIABETES
JI Diabetes
PD FEB
PY 2017
VL 66
IS 2
BP 474
EP 482
DI 10.2337/db16-0933
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA EI7PS
UT WOS:000392691000024
PM 27993926
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Tamura, Y
   Omura, T
   Toyoshima, K
   Araki, A
AF Tamura, Yoshiaki
   Omura, Takuya
   Toyoshima, Kenji
   Araki, Atsushi
TI Nutrition Management in Older Adults with Diabetes: A Review on the
   Importance of Shifting Prevention Strategies from Metabolic Syndrome to
   Frailty
SO NUTRIENTS
LA English
DT Review
DE diabetes mellitus; nutrition management; elderly; frailty; cognitive
   impairment
ID MILD COGNITIVE IMPAIRMENT; VITAMIN-D SUPPLEMENTATION; JAPANESE
   ELDERLY-PATIENTS; BONE-MINERAL DENSITY; BODY-MASS INDEX;
   QUALITY-OF-LIFE; SARCOPENIC OBESITY; CARDIOVASCULAR-DISEASE; OXIDATIVE
   STRESS; MUSCLE MASS
AB The increasing prevalence of older adults with diabetes has become a major social burden. Diabetes, frailty, and cognitive dysfunction are closely related to the mechanisms of aging. Insulin resistance, arteriosclerosis, chronic inflammation, oxidative stress, and mitochondrial dysfunction may be common mechanisms shared by frailty and cognitive impairment. Hyperglycemia, hypoglycemia, obesity, vascular factors, physical inactivity, and malnutrition are important risk factors for cognitive impairment and frailty in older adults with diabetes. The impact of nutrients on health outcomes varies with age; thus, shifting diet therapy strategies from the treatment of obesity/metabolic syndrome to frailty prevention may be necessary in patients with diabetes who are over 75 years of age, have frailty or sarcopenia, and experience malnutrition. For the prevention of frailty, optimal energy intake, sufficient protein and vitamin intake, and healthy dietary patterns should be recommended. The treatment of diabetes after middle age should include the awareness of proper glycemic control aimed at extending healthy life expectancy with proper nutrition, exercise, and social connectivity. Nutritional therapy in combination with exercise, optimal glycemic and metabolic control, and social participation/support for frailty prevention can extend healthy life expectancy and maintain quality of life in older adults with diabetes mellitus.
C1 [Tamura, Yoshiaki; Omura, Takuya; Toyoshima, Kenji; Araki, Atsushi] Tokyo Metropolitan Geriatr Hosp, Dept Diabet Metab & Endocrinol, Itabashi Ku, 35-2 Sakae Cho, Tokyo 1730015, Japan.
C3 Tokyo Metropolitan Institute of Gerontology
RP Araki, A (corresponding author), Tokyo Metropolitan Geriatr Hosp, Dept Diabet Metab & Endocrinol, Itabashi Ku, 35-2 Sakae Cho, Tokyo 1730015, Japan.
EM tamurayo@tmghig.jp; takuya_omura@tmghig.jp; kenji_toyoshima@tmghig.jp;
   aaraki@tmghig.jp
RI Omura, Takuya/X-4839-2019; Araki, Atsushi/JVE-0081-2024
OI Omura, Takuya/0000-0001-5490-8653; Araki, Atsushi/0000-0001-9088-2841;
   toyoshima, kenji/0000-0002-1220-273X
FU National Center for Geriatrics and Gerontology [30-1, 28-30];
   Grants-in-Aid for Scientific Research [20K19737] Funding Source: KAKEN
FX This study was supported by a grant from the Research Funding for
   Longevity Sciences (28-30, 30-1) from the National Center for Geriatrics
   and Gerontology.
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NR 202
TC 131
Z9 136
U1 10
U2 64
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD NOV
PY 2020
VL 12
IS 11
AR 3367
DI 10.3390/nu12113367
PG 29
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nutrition & Dietetics
GA OY8RQ
UT WOS:000594508600001
PM 33139628
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Bowden-Davies, K
   Connolly, J
   Burghardt, P
   Koch, LG
   Britton, SL
   Burniston, JG
AF Bowden-Davies, Kelly
   Connolly, Joanne
   Burghardt, Paul
   Koch, Lauren G.
   Britton, Steven L.
   Burniston, Jatin G.
TI Label-free profiling of white adipose tissue of rats exhibiting high or
   low levels of intrinsic exercise capacity
SO PROTEOMICS
LA English
DT Article
DE Adipokines; Aerobic capacity; Animal proteomics; Label-free
   quantitation; Metabolic syndrome; Obesity
ID LOW AEROBIC CAPACITY; HIGH-FAT DIET; DATA-INDEPENDENT ANALYSIS;
   ARTIFICIAL SELECTION; ADIPOCYTE PROTEOME; INSULIN-RESISTANCE; METABOLIC
   SYNDROME; OXIDATIVE STRESS; RUNNING CAPACITY; SKELETAL-MUSCLE
AB Divergent selection has created rat phenotypes of high- and low-capacity runners (HCR and LCR, respectively) that have differences in aerobic capacity and correlated traits such as adiposity. We analyzed visceral adipose tissue of HCR and LCR using label-free high-definition MS (elevated energy) profiling. The running capacity of HCR was ninefold greater than LCR. Proteome profiling encompassed 448 proteins and detected 30 significant (p <0.05; false discovery rate <10%, calculated using q-values) differences. Approximately half of the proteins analyzed were of mitochondrial origin, but there were no significant differences in the abundance of proteins involved in aerobic metabolism. Instead, adipose tissue of LCR rats exhibited greater abundances of proteins associated with adipogenesis (e.g. cathepsin D), ER stress (e.g. 78 kDa glucose response protein), and inflammation (e.g. Ig gamma-2B chain C region). Whereas the abundance antioxidant enzymes such as superoxide dismutase [Cu-Zn] was greater in HCR tissue. Putative adipokines were also detected, in particular protein S100-B, was 431% more abundant in LCR adipose tissue. These findings reveal low running capacity is associated with a pathological profile in visceral adipose tissue proteome despite no detectable differences in mitochondrial protein abundance.
C1 [Bowden-Davies, Kelly; Burniston, Jatin G.] Liverpool John Moores Univ, Res Inst Sport & Exercise Sci, Liverpool L3 3AF, Merseyside, England.
   [Connolly, Joanne] Waters MSHQ, Manchester, Lancs, England.
   [Burghardt, Paul; Koch, Lauren G.; Britton, Steven L.] Univ Michigan, Dept Anaesthesiol, Ann Arbor, MI 48109 USA.
   [Britton, Steven L.] Norwegian Univ Sci & Technol, KG Jebsen Ctr Exercise Med, Dept Circulat & Med Imaging, N-7034 Trondheim, Norway.
C3 Liverpool John Moores University; Waters UK; University of Michigan
   System; University of Michigan; Norwegian University of Science &
   Technology (NTNU)
RP Burniston, JG (corresponding author), Liverpool John Moores Univ, Res Inst Sport & Exercise Sci, Muscle Physiol & Prote Lab, Tom Reilly Bldg,Byrom St, Liverpool L3 3AF, Merseyside, England.
EM j.burniston@ljmu.ac.uk
RI Burniston, Jatin/AAB-8831-2020; Koch, Lauren/D-1258-2010
OI Ballantyne (Connolly), Joanne/0009-0008-6815-6198; Bowden Davies, Kelly
   A/0000-0002-9448-0732
FU Office of Research Infrastructure Programs/OD [R24OD010950]; National
   Institutes of Health [R01DK099034, R01DK077200, R01GM104194]; National
   Institute of Diabetes and Digestive and Kidney Diseases [P30DK020572]
   Funding Source: NIH RePORTER
FX The LCR-HCR rat model system was funded by the Office of Research
   Infrastructure Programs/OD grant R24OD010950 and by grant R01DK099034
   (to L.G.K. and S.L.B.) from the National Institutes of Health. S.L.B.
   was also supported by National Institutes of Health grants R01DK077200,
   and R01GM104194. We acknowledge the expert care of the rat colony
   provided by Molly Kalahar and Lori Heckenkamp. Contact L.G.K.
   (lgkoch@med.umich.edu) or S.L.B. (brittons@umich.edu) for information on
   the LCR and HCR rats: these rat models are maintained as an
   international resource with support from the Department of
   Anaesthesiology at the University of Michigan, Ann Arbor, MI, USA.
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NR 46
TC 9
Z9 13
U1 0
U2 14
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1615-9853
EI 1615-9861
J9 PROTEOMICS
JI Proteomics
PD JUL
PY 2015
VL 15
IS 13
BP 2342
EP 2349
DI 10.1002/pmic.201400537
PG 8
WC Biochemical Research Methods; Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA CL9BA
UT WOS:000357267700022
PM 25758023
OA Green Accepted, Green Submitted
DA 2025-06-11
ER

PT J
AU Botezelli, JD
   Cambri, LT
   Ghezzi, AC
   Dalia, RA
   Scariot, PPM
   Ribeiro, C
   Voltarelli, FA
   Mello, MAR
AF Botezelli, Jose D.
   Cambri, Lucieli T.
   Ghezzi, Ana C.
   Dalia, Rodrigo A.
   Scariot, Pedro P. M.
   Ribeiro, Carla
   Voltarelli, Fabricio A.
   Mello, Maria A. R.
TI Different exercise protocols improve metabolic syndrome markers, tissue
   triglycerides content and antioxidant status in rats
SO DIABETOLOGY & METABOLIC SYNDROME
LA English
DT Article
DE Physical exercise; liver damage; oxidative stress; rats
ID LACTATE STEADY-STATE; INSULIN-RESISTANCE; OXIDATIVE STRESS; WEIGHT-LOSS;
   OBESITY; LIVER; OVERWEIGHT; DISEASE; GLUCOSE; WOMEN
AB Background: An increase in the prevalence of obesity entails great expenditure for governments. Physical exercise is a powerful tool in the combat against obesity and obesity-associated diseases. This study sought to determine the effect of three different exercise protocols on metabolic syndrome and lipid peroxidation markers and the activity of antioxidant enzymes in adult Wistar rats (120 days old).
   Methods: Animals were randomly divided into four groups: the control (C) group was kept sedentary throughout the study; the aerobic group (A) swam1 h per day, 5 days per week, at 80% lactate threshold intensity; the strength group (S) performed strength training with four series of 10 jumps, 5 days per week; and the Concurrent group (AS) was trained using the aerobic protocol three days per week and the strength protocol two days per week.
   Results: Groups A and S exhibited a reduction in body weight compared to group C. All exercised animals showed a reduction in triglyceride concentrations in fatty tissues and the liver. Exercised animals also exhibited a reduction in lipid peroxidation markers (TBARS) and an increase in serum superoxide dismutase activity. Animals in group A had increased levels of liver catalase and superoxide dismutase activities.
   Conclusions: We concluded that all physical activity protocols improved the antioxidant systems of the animals and decreased the storage of triglycerides in the investigated tissues.
C1 [Botezelli, Jose D.; Cambri, Lucieli T.; Ghezzi, Ana C.; Dalia, Rodrigo A.; Scariot, Pedro P. M.; Ribeiro, Carla; Mello, Maria A. R.] Sao Paulo State Univ UNESP, Dept Phys Educ, BR-13607331 Rio Claro, Brazil.
   [Voltarelli, Fabricio A.] Mato Grosso Fed Univ UFMT, Dept Phys Educ, BR-78550000 Culaba, Brazil.
C3 Universidade Estadual Paulista; Universidade Federal de Mato Grosso do
   Sul
RP Botezelli, JD (corresponding author), Sao Paulo State Univ UNESP, Dept Phys Educ, 24-A Av 1515, BR-13607331 Rio Claro, Brazil.
EM jdbotezelli@yahoo.com.br
RI Cambri, Lucieli/I-5964-2012; Scariot, Pedro/W-3268-2017; Voltarelli,
   Fabrício/M-6496-2019
OI Scariot, Pedro/0000-0003-2976-8999
CR Aebi H, 1984, Methods Enzymol, V105, P121
   [Anonymous], METODOS BIOQUIMICA C
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NR 46
TC 22
Z9 25
U1 0
U2 12
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1758-5996
J9 DIABETOL METAB SYNDR
JI Diabetol. Metab. Syndr.
PD DEC 19
PY 2011
VL 3
AR 35
DI 10.1186/1758-5996-3-35
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 915UW
UT WOS:000302053900001
PM 22182600
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Nair, AR
   Mariappan, N
   Stull, AJ
   Francis, J
AF Nair, Anand R.
   Mariappan, Nithya
   Stull, April J.
   Francis, Joseph
TI Blueberry supplementation attenuates oxidative stress within monocytes
   and modulates immune cell levels in adults with metabolic syndrome: a
   randomized, double-blind, placebo-controlled trial
SO FOOD & FUNCTION
LA English
DT Article
ID DENDRITIC CELLS; ENDOTHELIAL DYSFUNCTION; CARDIOVASCULAR-DISEASES;
   VASCULAR FUNCTION; BLOOD-PRESSURE; DNA-DAMAGE; CONSUMPTION; OBESE;
   INFLAMMATION; STIMULATION
AB Background: Blueberries (BB) have been shown to improve insulin sensitivity and endothelial function in obese and pre-diabetic humans, and decrease oxidative stress and inflammation, and ameliorate cardiorenal damage in rodents. This indicates that blueberries have a systemic effect and are not limited to a particular organ system. In order for blueberries to exert beneficial effects on the whole body, the mechanism would logically have to operate through modulation of cellular humoral factors. Objective: This study investigated the role of blueberries in modulating immune cell levels and attenuating circulatory and monocyte inflammation and oxidative stress in metabolic syndrome (MetS) subjects. Design: A double-blind, randomized and placebo-controlled study was conducted in adults with MetS, in which they received a blueberry (22.5 g freeze-dried) or placebo smoothie twice daily for six weeks. Free radical production in the whole blood and monocytes, dendritic cell (DC) levels, expression of cytokines in monocytes and serum inflammatory markers were assessed pre-and post-intervention. Results: Baseline free radical levels in MetS subjects' samples were not different between groups. Treatment with blueberries markedly decreased superoxide and total reactive oxygen species (ROS) in whole blood and monocytes compared to the placebo (p <= 0.05). The baseline DC numbers in MetS subjects' samples in both groups were not different, however treatment with blueberries significantly increased myeloid DC (p = 0.05) and had no effect on plasmacytoid cells. Blueberry treatment decreased monocyte gene expression of TNF alpha, IL-6, TLR4 and reduced serum GMCSF in MetS subjects when compared to the placebo treatment (p <= 0.05). Conclusions: The findings of the current study demonstrate that blueberries exert immunomodulatory effects and attenuate oxidative stress and inflammation in adults with MetS.
C1 [Nair, Anand R.; Mariappan, Nithya; Francis, Joseph] Louisiana State Univ, Sch Vet Med, Comparat Biomed Sci, Baton Rouge, LA 70803 USA.
   [Stull, April J.] Univ Maryland Eastern Shore, Dept Human Ecol, Princess Anne, MD 21853 USA.
   [Stull, April J.] Louisiana State Univ Syst, Pennington Biomed Res Ctr, Baton Rouge, LA 70808 USA.
   [Mariappan, Nithya] UAB, Sch Med, Div Mol & Translat Biomed, Dept Anesthesiol & Perioperat Med, Birmingham, AL 35294 USA.
C3 Louisiana State University School of Veterinary Medicine; Louisiana
   State University System; Louisiana State University; University System
   of Maryland; University of Maryland Eastern Shore; Louisiana State
   University System; Louisiana State University; Pennington Biomedical
   Research Center; University of Alabama System; University of Alabama
   Birmingham
RP Francis, J (corresponding author), Louisiana State Univ, Sch Vet Med, Comparat Biomed Sci, Baton Rouge, LA 70803 USA.
EM jfrancis@lsu.edu
RI Francis, Joseph/I-4984-2012
OI Francis, Joseph/0000-0002-9502-4579
FU United States Highbush Blueberry Council; National Center for
   Complementary and Integrative Health of the National Institutes of
   Health [K01AT006975, P50AT00277]; NORC Center Grant [2 P30
   DK072476-11A1]
FX Research reported in this publication was supported by the United States
   Highbush Blueberry Council (JF) and the National Center for
   Complementary and Integrative Health of the National Institutes of
   Health under award numbers K01AT006975 (AJS) and P50AT00277 (Botanical
   Dietary Supplements Research Center). This project used facilities that
   are supported in part by a NORC Center Grant # 2 P30 DK072476-11A1
   entitled "Pennington/Louisiana NORC". The content is solely the
   responsibility of the authors and does not necessarily represent the
   official views of the United States Highbush Blueberry Council and the
   National Institutes of Health.
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NR 53
TC 45
Z9 49
U1 0
U2 17
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PD NOV
PY 2017
VL 8
IS 11
BP 4118
EP 4128
DI 10.1039/c7fo00815e
PG 11
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA FM9HW
UT WOS:000415578600027
PM 29019365
DA 2025-06-11
ER

PT J
AU Farah, D
   Nunes, J
   Sartori, M
   Dias, DD
   Sirvente, R
   Silva, MB
   Fiorino, P
   Morris, M
   Llesuy, S
   Farah, V
   Irigoyen, MC
   De Angelis, KT
AF Farah, Daniela
   Nunes, Jonas
   Sartori, Michelle
   Dias, Danielle da Silva
   Sirvente, Raquel
   Silva, Maikon B.
   Fiorino, Patricia
   Morris, Mariana
   Llesuy, Susana
   Farah, Vera
   Irigoyen, Maria-Claudia
   De Angelis, Katia
TI Exercise Training Prevents Cardiovascular Derangements Induced by
   Fructose Overload in Developing Rats
SO PLOS ONE
LA English
DT Article
ID RENIN-ANGIOTENSIN SYSTEM; OXIDATIVE STRESS; METABOLIC SYNDROME;
   BLOOD-PRESSURE; LIPID-PEROXIDATION; INSULIN-RESISTANCE;
   EXPERIMENTAL-MODEL; PHYSICAL-ACTIVITY; AUTONOMIC CONTROL; DYSFUNCTION
AB The risks of chronic diseases associated with the increasing consumption of fructose-laden foods are amplified by the lack of regular physical activity and have become a serious public health issue worldwide. Moreover, childhood eating habits are strongly related to metabolic syndrome in adults. Thus, we aimed to investigate the preventive role of exercise training undertaken concurrently with a high fructose diet on cardiac function, hemodynamics, cardiovascular autonomic modulation and oxidative stress in male rats after weaning. Male Wistar rats were divided into 4 groups (n = 8/group):Sedentary control (SC), Trained control (TC), Sedentary Fructose (SF) and Trained Fructose (TF). Training was performed on a treadmill (8 weeks, 40-60% of maximum exercise test). Evaluations of cardiac function, hemodynamics, cardiovascular autonomic modulation and oxidative stress in plasma and in left ventricle (LV) were performed. Chronic fructose overload induced glucose intolerance and an increase in white adipose tissue (WAT) weight, in myocardial performance index (MPI) (SF:0.42 +/- 0.04 vs. SC:0.24 +/- 0.05) and in arterial pressure (SF:122 +/- 3 vs. SC:113 +/- 1 mmHg) associated with increased cardiac and vascular sympathetic modulation. Fructose also induced unfavorable changes in oxidative stress profile (plasmatic protein oxidationSF: 3.30 +/- 0.09 vs. SC:1.45 +/- 0.08 nmol/mg prot; and LV total antioxidant capacity (TRAP)SF: 2.5 +/- 0.5 vs. SC:12.7 +/- 1.7 uM trolox). The TF group showed reduced WAT, glucose intolerance, MPI (0.35 +/- 0.04), arterial pressure (118 +/- 2mmHg), sympathetic modulation, plasmatic protein oxidation and increased TRAP when compared to SF group. Therefore, our findings indicate that cardiometabolic dysfunctions induced by fructose overload early in life may be prevented by moderate aerobic exercise training.
C1 [Farah, Daniela; Nunes, Jonas; Fiorino, Patricia; Farah, Vera] Univ Presbiteriana Mackenzie, Lab Metab Cardiovasc & Renal Physiopharmacol, Sao Paulo, Brazil.
   [Farah, Daniela; Sartori, Michelle; Sirvente, Raquel; Silva, Maikon B.; Irigoyen, Maria-Claudia] Sao Paulo Univ FMUSP, Sch Med, Lab Expt Hypertens,Heart Inst INCOR, Sao Paulo, Brazil.
   [Sartori, Michelle; Dias, Danielle da Silva; De Angelis, Katia] Univ Nove de Julho, Lab Translat Physiol, Sao Paulo, Brazil.
   [Morris, Mariana] Nova Southeastern Univ, Inst Neuro Immune Med, Ft Lauderdale, FL USA.
   [Llesuy, Susana] Univ Buenos Aires, Dept Gen & Inorgan Chem, Buenos Aires, DF, Argentina.
C3 Universidade Presbiteriana Mackenzie; Universidade de Sao Paulo;
   Universidade Nove de Julho; Nova Southeastern University; University of
   Buenos Aires
RP De Angelis, KT (corresponding author), Univ Nove de Julho, Lab Translat Physiol, Sao Paulo, Brazil.
EM kangelis@uni9.pro.br
RI da Silva Dias, Danielle/AAN-7618-2020; Farah, Vera/ABA-1171-2021; DE
   ANGELIS, KATIA/I-6098-2016; Irigoyen, maria Claudia/N-6880-2014
OI Farah, Daniela/0000-0002-9727-9460; Francisca Llesuy,
   Susana/0000-0001-6818-051X; Farah, Vera/0000-0002-5439-3079; DE ANGELIS,
   KATIA/0000-0002-3640-9049; Irigoyen, maria Claudia/0000-0003-2097-3662
FU CNPq [457200/2014-6, 309292/2014-0]; FAPESP [2015/11223-6,
   2012/01873-5]; CAPES [88881.062178/2014-01]; CNPq Fellowship (CNPq-BPQ);
   Vinnova [2012-01873] Funding Source: Vinnova
FX This study was supported by CNPq (457200/2014-6; 309292/2014-0) and
   FAPESP (2015/11223-6; 2012/01873-5); CAPES (88881.062178/2014-01). Katia
   De Angelis and Maria-Claudia Irigoyen are recipients of CNPq Fellowship
   (CNPq-BPQ). The funders had no role in study design, data collection and
   analysis, decision to publish, or preparation of the manuscript.
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NR 54
TC 18
Z9 19
U1 0
U2 9
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD DEC 8
PY 2016
VL 11
IS 12
AR e0167291
DI 10.1371/journal.pone.0167291
PG 15
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA EE4OA
UT WOS:000389580900023
PM 27930685
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Ro, SH
   Bae, J
   Jang, Y
   Myers, JF
   Chung, SK
   Yu, JJ
   Natarajan, SK
   Franco, R
   Song, HS
AF Ro, Seung-Hyun
   Bae, Jiyoung
   Jang, Yura
   Myers, Jacob F.
   Chung, Soonkyu
   Yu, Jiujiu
   Natarajan, Sathish Kumar
   Franco, Rodrigo
   Song, Hyun-Seob
TI Arsenic Toxicity on Metabolism and Autophagy in Adipose and Muscle
   Tissues
SO ANTIOXIDANTS
LA English
DT Review
DE arsenic; adipose; muscle; autophagy; oxidative stress; mitochondrial
   dysfunction; metabolism; metabolic syndrome; metabolic disease
ID STIMULATED INSULIN-SECRETION; INDUCED OXIDATIVE STRESS; SKELETAL-MUSCLE;
   DRINKING-WATER; TRIVALENT ARSENICALS; DIABETES-MELLITUS;
   LIPID-METABOLISM; UNITED-STATES; NADPH OXIDASE; EXPOSURE
AB Arsenic, a naturally occurring metalloid derived from the environment, has been studied worldwide for its causative effects in various cancers. However, the effects of arsenic toxicity on the development and progression of metabolic syndrome, including obesity and diabetes, has received less attention. Many studies suggest that metabolic dysfunction and autophagy dysregulation of adipose and muscle tissues are closely related to the development of metabolic disease. In the USA, arsenic contamination has been reported in some ground water, soil and grain samples in major agricultural regions, but the effects on adipose and muscle tissue metabolism and autophagy have not been investigated much. Here, we highlight arsenic toxicity according to the species, dose and exposure time and the effects on adipose and muscle tissue metabolism and autophagy. Historically, arsenic was used as both a poison and medicine, depending on the dose and treatment time. In the modern era, arsenic intoxication has significantly increased due to exposure from water, soil and food, which could be a contributing factor in the development and progression of metabolic disease. From this review, a better understanding of the pathogenic mechanisms by which arsenic alters metabolism and autophagy regulation could become a cornerstone leading to the development of therapeutic strategies against arsenic-induced toxicity and metabolic disease.
C1 [Ro, Seung-Hyun; Bae, Jiyoung; Jang, Yura; Myers, Jacob F.] Univ Nebraska Lincoln, Dept Biochem, Lincoln, NE 68588 USA.
   [Ro, Seung-Hyun; Bae, Jiyoung; Jang, Yura; Myers, Jacob F.] Univ Nebraska Lincoln, Redox Biol Ctr, Lincoln, NE 68588 USA.
   [Bae, Jiyoung] Univ Wisconsin, Dept Cell & Regenerat Biol, Sch Med & Publ Hlth, Madison, WI 53705 USA.
   [Jang, Yura] Johns Hopkins Univ, Inst Cell Engn, Dept Neurol, Sch Med, Baltimore, MD 21205 USA.
   [Jang, Yura] US FDA, Ctr Drug Evaluat & Res, Off Biotechnol Prod, Immunol Lab, Silver Spring, MD 20993 USA.
   [Myers, Jacob F.] Thomas Jefferson Univ, Dept Microbiol & Immunol, Sidney Kimmel Med Coll, Philadelphia, PA 19107 USA.
   [Myers, Jacob F.] Thomas Jefferson Univ, Jefferson Coll Life Sci, MD PhD Program, Philadelphia, PA 19107 USA.
   [Yu, Jiujiu; Natarajan, Sathish Kumar] Univ Nebraska Lincoln, Dept Nutr & Hlth Sci, Lincoln, NE 68583 USA.
   [Franco, Rodrigo] Univ Nebraska Lincoln, Sch Vet Med & Biomed Sci, Lincoln, NE 68583 USA.
   [Franco, Rodrigo] Univ Nebraska Lincoln, Redox Biol Ctr, Lincoln, NE 68583 USA.
   [Song, Hyun-Seob] Univ Nebraska Lincoln, Dept Biol Syst Engn, Lincoln, NE 68583 USA.
   [Song, Hyun-Seob] Univ Nebraska Lincoln, Nebraska Food Hlth Ctr, Dept Food Sci & Technol, Lincoln, NE 68588 USA.
C3 University of Nebraska System; University of Nebraska Lincoln;
   University of Nebraska System; University of Nebraska Lincoln;
   University of Wisconsin System; University of Wisconsin Madison; Johns
   Hopkins University; US Food & Drug Administration (FDA); Thomas
   Jefferson University; Thomas Jefferson University; University of
   Nebraska System; University of Nebraska Lincoln; University of Nebraska
   System; University of Nebraska Lincoln; University of Nebraska System;
   University of Nebraska Lincoln; University of Nebraska System;
   University of Nebraska Lincoln; University of Nebraska System;
   University of Nebraska Lincoln
RP Ro, SH (corresponding author), Univ Nebraska Lincoln, Dept Biochem, Lincoln, NE 68588 USA.; Ro, SH (corresponding author), Univ Nebraska Lincoln, Redox Biol Ctr, Lincoln, NE 68588 USA.
EM shro@unl.edu; jbae42@wisc.edu; abc211@hanmail.net;
   jacob.myers@students.jefferson.edu; soonkyuchung@umass.edu;
   jyu18@unl.edu; snatarajan2@unl.edu; rodrigo.franco@unl.edu;
   hsong5@unl.edu
RI Song, Hyun-Seob/IAQ-0503-2023; Bae, Jiyoung/AAL-1829-2021; Song,
   Hyun-Seob/C-4802-2018; Franco, Rodrigo/D-9470-2013
OI Natarajan, Sathish kumar/0000-0001-7491-8592; BAE,
   JIYOUNG/0000-0003-2367-7578; Song, Hyun-Seob/0000-0002-2154-6358; Myers,
   Jacob/0000-0002-2395-1576; Franco, Rodrigo/0000-0003-3241-8615
FU National Science Foundation (NSF)-REU site in the form of Training in
   Redox Biology grant [DBI-1757951]; National Institute of Health
   (NIH)/National Heart, Lung and Blood Institute (NHLBI) grant under Ruth
   L. Kirschstein National Research Service Award (NRSA) from the
   University of Wisconsin Cardiovascular Research Center [T32 HL007936];
   University of Nebraska Collaboration Initiative Team Formation and
   Publication Grant; University of Nebraska ARD/ORED/BIOC; Nebraska
   Tobacco Settlement Biomedical Research enhancement funds; Nebraska
   Center for the Prevention of Obesity Diseases (NPOD) Program Seed Grant
   from the National Institute of General Medical Sciences (NIGMS) of the
   NIH [P20 GM104320]; University of Nebraska Collaboration Initiative Team
   Seed Grant
FX This work was supported by National Science Foundation (NSF)-REU site in
   the form of Training in Redox Biology (DBI-1757951) grant to J.F.M.; the
   National Institute of Health (NIH)/National Heart, Lung and Blood
   Institute (NHLBI) grant under Ruth L. Kirschstein National Research
   Service Award (NRSA) (T32 HL007936) from the University of Wisconsin
   Cardiovascular Research Center to J.B.; the University of Nebraska
   Collaboration Initiative Team Formation and Publication Grant to S.-H.R.
   and Samuel M. Cohen; the University of Nebraska Collaboration Initiative
   Team Seed Grant to S.-H.R. and H.-S.S.; and the University of Nebraska
   ARD/ORED/BIOC grants and Nebraska Tobacco Settlement Biomedical Research
   enhancement funds to S.-H.R. and H.-S.S. This research was supported in
   part by the Nebraska Center for the Prevention of Obesity Diseases
   (NPOD) Program Seed Grant from the National Institute of General Medical
   Sciences (NIGMS) of the NIH under award number P20 GM104320.
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NR 149
TC 10
Z9 11
U1 1
U2 19
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD APR
PY 2022
VL 11
IS 4
AR 689
DI 10.3390/antiox11040689
PG 20
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA 0S1LA
UT WOS:000786041900001
PM 35453374
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Oltman, CL
   Richou, LL
   Davidson, EP
   Coppey, LJ
   Lund, DD
   Yorek, MA
AF Oltman, Christine L.
   Richou, Laura L.
   Davidson, Eric P.
   Coppey, Lawrence J.
   Lund, Donald D.
   Yorek, Mark A.
TI Progression of coronary and mesenteric vascular dysfunction in Zucker
   obese and Zucker diabetic fatty rats
SO AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
LA English
DT Article
DE metabolic syndrome; Type 2 diabetes; oxidative stress; acetylcholine
ID NERVE CONDUCTION-VELOCITY; ENDONEURIAL BLOOD-FLOW; EPINEURIAL
   ARTERIOLES; ARACHIDONIC-ACID; OXIDANT STRESS; SCIATIC-NERVE; REACTIVITY;
   VASODILATION; INSULIN; MECHANISM
AB We investigated the progression of vascular dysfunction associated with the metabolic syndrome with and without hyperglycemia in lean, Zucker obese, and Zucker diabetic fatty (ZDF) rats. Responses of aorta and small coronary and mesenteric arteries were measured to endothelium-dependent and -independent vasodilators. Indices of oxidative stress were increased in serum from ZDF rats throughout the study, whereas values were increased in Zucker obese rats later in the study [thiobarbituric acid reactive substances: 0.45 +/- 0.02, 0.59 +/- 0.03 (P < 0.05), and 0.58 +/- 0.03 (P < 0.05) mu g/ml in serum from 28- to 40-wk-old lean, Zucker obese, and ZDF rats, respectively]. Acetylcholine (ACh)-induced relaxation was not altered in vessels from lean animals from 8-40 wk. ACh-induced relaxation was nearly abolished in coronary arteries from 28 to 36-wk-old Zucker obese rats and by 16-36 wk in ZDF rats and was attenuated in aorta and mesenteric vessels from ZDF rats [%relaxation to 10 mu M ACh: 72.2 +/- 7.1, 17.9 +/- 5.9 (P < 0.05), and 23.0 +/- 4.5 (P < 0.05) in coronary vessels; and 67.9 +/- 9.2, 50.1 +/- 5.5, and 42.3 +/- 4.7 (P < 0.05) in mesenteric vessels from 28- to 40-wk-old lean, Zucker obese, and ZDF rats, respectively]. The attenuated ACh-induced relaxation was improved when vessels were incubated with tiron, suggesting superoxide as a mechanism of endothelial dysfunction. Sodium nitroprusside-induced relaxation was not altered in aorta or coronary arteries and was potentiated in mesenteric arteries from Zucker obese rats. Our data suggest that diabetes enhances the progression of vascular dysfunction. Increases in indices of oxidative stress precede the development of dysfunction and may serve as a marker of endothelial damage.
C1 Iowa Dept Vet Affairs, Iowa City, IA USA.
   Univ Iowa, Coll Med, Dept Internal Med, Iowa City, IA 52242 USA.
C3 US Department of Veterans Affairs; Veterans Health Administration (VHA);
   Iowa City VA Health Care System; University of Iowa
RP Oltman, CL (corresponding author), VA Med Ctr, Rm 204,Bld 40,Highway 6 W, Iowa City, IA 52246 USA.
EM christine-oltman@uiowa.edu
RI Yorek, Mark/AAC-3136-2021
OI Yorek, Mark/0000-0001-7737-5554
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NR 25
TC 117
Z9 130
U1 0
U2 2
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0363-6135
J9 AM J PHYSIOL-HEART C
JI Am. J. Physiol.-Heart Circul. Physiol.
PD OCT
PY 2006
VL 291
IS 4
BP H1780
EP H1787
DI 10.1152/ajpheart.01297.2005
PG 8
WC Cardiac & Cardiovascular Systems; Physiology; Peripheral Vascular
   Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Physiology
GA 084CP
UT WOS:000240509700035
PM 16714356
DA 2025-06-11
ER

PT J
AU Dokras, A
AF Dokras, Anuja
TI Noncontraceptive use of oral combined hormonal contraceptives in
   polycystic ovary syndrome-risks versus benefits
SO FERTILITY AND STERILITY
LA English
DT Review
DE Polycystic ovary syndrome; hormonal contraceptives; lipids; metabolic
   syndrome
ID C-REACTIVE PROTEIN; METABOLIC SYNDROME; ANDROGEN EXCESS; CANCER-RISK;
   FLUTAMIDE-METFORMIN; CYPROTERONE-ACETATE; ENDOMETRIAL CANCER;
   INSULIN-RESISTANCE; ETHINYL ESTRADIOL; BREAST-CANCER
AB The use of steroid sex hormones for noncontraceptive benefits has been endorsed by several medical societies. In women with polycystic ovary syndrome (PCOS), hormonal contraceptives are first-line therapy for concurrent treatment of menstrual irregularity, acne, and hirsutism. The association of PCOS with obesity, diabetes, and dyslipidemia frequently brings up the debate regarding risks versus benefits of hormonal contraceptives in this population. In women with PCOS, the lack of large-scale studies evaluating the risks with varying doses of ethinyl estradiol, types of progestins, and presence of confounding factors such as obesity, smoking, and other cardiometabolic comorbidities is a significant limitation in these deliberations. Although it is important to assess the absolute risk for major morbidities including cardiovascular events, currently, there are a paucity of long-term data for these outcomes in PCOS. Most of the current studies do not suggest an increase in risk of prediabetes/diabetes, clinically significant dyslipidemia, inflammatory changes, or depressive/anxiety symptoms with oral contraceptive pill use. Screening of women with PCOS for cardiometabolic and psychiatric comorbidities is routinely recommended. This information should be used by health care providers to individualize the choice of hormonal contraceptive treatment, adequately counsel patients regarding risks and benefits, and formulate an appropriate follow-up plan. (C) 2016 by American Society for Reproductive Medicine.
C1 [Dokras, Anuja] Univ Penn, Dept Obstet & Gynecol, 3701 Market St, Philadelphia, PA 19104 USA.
C3 University of Pennsylvania
RP Dokras, A (corresponding author), Univ Penn, Dept Obstet & Gynecol, 3701 Market St, Philadelphia, PA 19104 USA.
EM adokras@obgyn.upenn.edu
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NR 78
TC 19
Z9 21
U1 0
U2 36
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0015-0282
EI 1556-5653
J9 FERTIL STERIL
JI Fertil. Steril.
PD DEC
PY 2016
VL 106
IS 7
BP 1572
EP 1579
DI 10.1016/j.fertnstert.2016.10.027
PG 8
WC Obstetrics & Gynecology; Reproductive Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology; Reproductive Biology
GA EF9RU
UT WOS:000390668400006
PM 27817838
OA Bronze
DA 2025-06-11
ER

PT J
AU Eichers, ER
   Abd-El-Barr, MM
   Paylor, R
   Lewis, RA
   Bi, WM
   Lin, XD
   Meehan, TP
   Stockton, DW
   Wu, SM
   Lindsay, E
   Justice, MJ
   Beales, PL
   Katsanis, N
   Lupski, JR
AF Eichers, Erica R.
   Abd-El-Barr, Muhammad M.
   Paylor, Richard
   Lewis, Richard Alan
   Bi, Weimin
   Lin, Xiaodi
   Meehan, Thomas P.
   Stockton, David W.
   Wu, Samuel M.
   Lindsay, Elizabeth
   Justice, Monica J.
   Beales, Philip L.
   Katsanis, Nicholas
   Lupski, James R.
TI Phenotypic characterization of Bbs4 null mice reveals
   age-dependent penetrance and variable expressivity
SO HUMAN GENETICS
LA English
DT Article
ID BARDET-BIEDL-SYNDROME; MCKUSICK-KAUFMAN-SYNDROME; BEHAVIORAL-TEST
   BATTERIES; HUMAN OBESITY SYNDROME; TRIALLELIC INHERITANCE; METABOLIC
   SYNDROME; KNOCKOUT MICE; SYNDROME GENE; MOUSE MODELS; MUTATIONS
AB Bardet-Biedl syndrome (BBS) is a rare oligogenic disorder exhibiting both clinical and genetic heterogeneity. Although the BBS phenotype is variable both between and within families, the syndrome is characterized by the hallmarks of developmental and learning difficulties, post-axial polydactylia, obesity, hypogenitalism, renal abnormalities, retinal dystrophy, and several less frequently observed features. Eleven genes mutated in BBS patients have been identified, and more are expected to exist, since about 20-30% of all families cannot be explained by the known loci. To investigate the etiopathogenesis of BBS, we created a mouse null for one of the murine homologues, Bbs4, to assess the contribution of one gene to the pleiotropic murine Bbs phenotype. Bbs4 null mice, although initially runted compared to their littermates, ultimately become obese in a gender-dependent manner, females earlier and with more severity than males. Blood chemistry tests indicated abnormal lipid profiles, signs of liver dysfunction, and elevated insulin and leptin levels reminiscent of metabolic syndrome. As in patients with BBS, we found age-dependent retinal dystrophy. Behavioral assessment revealed that mutant mice displayed more anxiety-related responses and reduced social dominance. We noted the rare occurrence of birth defects, including neural tube defects and hydrometrocolpos, in the null mice. Evaluations of these null mice have uncovered phenotypic features with age-dependent penetrance and variable expressivity, partially recapitulating the human BBS phenotype.
C1 Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA.
   Baylor Coll Med, Dept Neurosci, Houston, TX 77030 USA.
   Baylor Coll Med, Dept Ophthalmol, Houston, TX 77030 USA.
   Baylor Coll Med, Dept Pediat, Houston, TX 77030 USA.
   Baylor Coll Med, Dept Med, Houston, TX 77030 USA.
   Baylor Coll Med, Dept Pediat, Houston, TX 77030 USA.
   Texas Childrens Hosp, Houston, TX 77030 USA.
   UCL, Inst Child Hlth, Mol Med Unit, London WC1N 1EH, England.
   Johns Hopkins Univ, McKusick Nathans Inst Genet Med, Baltimore, MD 21205 USA.
   Johns Hopkins Univ, Wilmer Eye Inst, Baltimore, MD 21205 USA.
C3 Baylor College of Medicine; Baylor College of Medicine; Baylor College
   of Medicine; Baylor College of Medicine; Baylor College of Medicine;
   Baylor College of Medicine; Baylor College of Medicine; Baylor College
   Medical Hospital; University of London; University College London; Johns
   Hopkins University; Johns Hopkins University; Johns Hopkins Medicine
RP Lupski, JR (corresponding author), Baylor Coll Med, Dept Mol & Human Genet, 1 Baylor Pl Room 604B, Houston, TX 77030 USA.
EM jlupski@bcm.edu
RI Katsanis, Nicholas/E-1837-2012; Beales, Philip/C-7367-2009
OI Abd-El-Barr, Muhammad/0000-0001-7151-2861; Katsanis,
   Nicholas/0000-0002-2480-0171
FU Medical Research Council [G0801843] Funding Source: Medline; NEI NIH HHS
   [EY02520, R01 EY016859, EY0446] Funding Source: Medline; NICHD NIH HHS
   [R01 HD42601, U01 HD39372] Funding Source: Medline; NIDDK NIH HHS [R01
   DK072301] Funding Source: Medline; Wellcome Trust Funding Source:
   Medline
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NR 70
TC 87
Z9 104
U1 0
U2 4
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0340-6717
J9 HUM GENET
JI Hum. Genet.
PD SEP
PY 2006
VL 120
IS 2
BP 211
EP 226
DI 10.1007/s00439-006-0197-y
PG 16
WC Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Genetics & Heredity
GA 073GF
UT WOS:000239730300008
PM 16794820
DA 2025-06-11
ER

PT J
AU Santamaría, R
   Díaz-Tocados, JM
   de Mier, MVPR
   Robles, A
   Salmerón-Rodríguez, MD
   Ruiz, E
   Vergara, N
   Aguilera-Tejero, E
   Raya, A
   Ortega, R
   Felsenfeld, A
   Muñoz-Castañeda, JR
   Martín-Malo, A
   Aljama, P
   Rodríguez, M
AF Santamaria, Rafael
   Diaz-Tocados, Juan M.
   Pendon-Ruiz de Mier, M. Victoria
   Robles, Ana
   Dolores Salmeron-Rodriguez, M.
   Ruiz, Erena
   Vergara, Noemi
   Aguilera-Tejero, Escolastico
   Raya, Ana
   Ortega, Rosa
   Felsenfeld, Arnold
   Munoz-Castaneda, Juan R.
   Martin-Malo, Alejandro
   Aljama, Pedro
   Rodriguez, Mariano
TI Increased Phosphaturia Accelerates The Decline in Renal Function: A
   Search for Mechanisms
SO SCIENTIFIC REPORTS
LA English
DT Article
ID CHRONIC KIDNEY-DISEASE; MORTALITY; DIETARY; PHOSPHORUS; METABOLISM;
   TOXICITY; RISK
AB In chronic kidney disease (CKD), high serum phosphate concentration is associated with cardiovascular disease and deterioration in renal function. In early CKD, the serum phosphate concentration is normal due to increased fractional excretion of phosphate. Our premise was that high phosphate intake even in patients with early CKD would result in an excessive load of phosphate causing tubular injury and accelerating renal function deterioration. In CKD 2-3 patients, we evaluated whether increased phosphaturia accelerates CKD progression. To have a uniform group of patients with early CKD, 95 patients with metabolic syndrome without overt proteinuria were followed for 2.7 +/- 1.6 years. The median decline in eGFR was 0.50 ml/min/1.73m(2)/year. Patients with a more rapid decrease in eGFR had greater phosphaturia. Moreover, the rate of decrease in eGFR inversely correlated with the degree of phosphaturia. Additionally, phosphaturia independently predicted renal function deterioration. In heminephrectomized rats, a high phosphate diet increased phosphaturia resulting in renal tubular damage associated with inflammation, oxidative stress and low klotho expression. Moreover, in rats with hyperphosphatemia and metabolic syndrome antioxidant treatment resulted in attenuation of renal lesions. In HEK-293 cells, high phosphate promoted oxidative stress while melatonin administration reduced ROS generation. Our findings suggest that phosphate loading in early CKD, results in renal damage and a more rapid decrease in renal function due to renal tubular injury.
C1 [Santamaria, Rafael; Pendon-Ruiz de Mier, M. Victoria; Robles, Ana; Dolores Salmeron-Rodriguez, M.; Ruiz, Erena; Vergara, Noemi; Munoz-Castaneda, Juan R.; Martin-Malo, Alejandro; Aljama, Pedro; Rodriguez, Mariano] Reina Sofia Univ Hosp, Serv Nephrol, Cordoba, Spain.
   [Santamaria, Rafael; Diaz-Tocados, Juan M.; Pendon-Ruiz de Mier, M. Victoria; Dolores Salmeron-Rodriguez, M.; Ruiz, Erena; Vergara, Noemi; Aguilera-Tejero, Escolastico; Raya, Ana; Munoz-Castaneda, Juan R.; Martin-Malo, Alejandro; Aljama, Pedro; Rodriguez, Mariano] Maimonides Biomed Res Inst Cordoba IMIBIC, Res Unit, Cordoba, Spain.
   [Santamaria, Rafael; Diaz-Tocados, Juan M.; Pendon-Ruiz de Mier, M. Victoria; Dolores Salmeron-Rodriguez, M.; Ruiz, Erena; Vergara, Noemi; Aguilera-Tejero, Escolastico; Raya, Ana; Munoz-Castaneda, Juan R.; Martin-Malo, Alejandro; Aljama, Pedro; Rodriguez, Mariano] Univ Cordoba, Cordoba, Spain.
   [Ortega, Rosa] Reina Sofia Univ Hosp, Dept Pathol, Cordoba, Spain.
   [Felsenfeld, Arnold] Univ Calif Los Angeles, Serv Nephrol, West Los Angeles VA, Los Angeles, CA USA.
   [Santamaria, Rafael; Martin-Malo, Alejandro; Aljama, Pedro; Rodriguez, Mariano] ISCIII, Red Invest Renal RedInRen, Madrid, Spain.
   [Santamaria, Rafael; Martin-Malo, Alejandro; Aljama, Pedro; Rodriguez, Mariano] EUTOX, Madrid, Spain.
C3 Hospital Universitario Reina Sofia - Cordoba; Universidad de Cordoba;
   Hospital Universitario Reina Sofia - Cordoba; US Department of Veterans
   Affairs; Veterans Health Administration (VHA); West Los Angeles VA
   Medical Center; University of California System; University of
   California Los Angeles; Instituto de Salud Carlos III
RP Muñoz-Castañeda, JR (corresponding author), Reina Sofia Univ Hosp, Serv Nephrol, Cordoba, Spain.; Muñoz-Castañeda, JR (corresponding author), Maimonides Biomed Res Inst Cordoba IMIBIC, Res Unit, Cordoba, Spain.; Muñoz-Castañeda, JR (corresponding author), Univ Cordoba, Cordoba, Spain.
RI Santamaria, Rafael/P-5819-2019; Segarra, Ana/C-6219-2017;
   Muñoz-Castañeda, Juan/AFQ-3443-2022; Díaz Tocados, Juan/I-8254-2018;
   Raya, Ana/A-9548-2017
OI Munoz-Castaneda, Juan R/0000-0002-9341-0724; Raya Bermudez, Ana
   Isabel/0000-0002-4489-9447; Rodriguez, Mariano/0000-0002-9380-6614;
   Santamaria, Rafael/0000-0002-2627-1445; Diaz Tocados, Juan
   Miguel/0000-0001-5192-5212
FU Spanish Government Grant from Programa Nacional I + D + I 2008-2011 from
   Instituto de Salud Carlos III [PI14/00638, PI14/00467]; European Funds
   (FEDER); Consejeria de Economia, Innovacion, Ciencia y Empleo from the
   Junta de Andalucia [CVI-7925]; REDINREN from Instituto de Salud Carlos
   III (ISCIII); EUTOX; Junta de Andalucia [PI-0311-2014]; EUTOX
   [PI12/01866]; Nicolas Monardes Programme, Consejeria de Salud-SAS (Junta
   de Andalucia)
FX This work has been partially supported by a Spanish Government Grant
   from the Programa Nacional I + D + I 2008-2011 from the Instituto de
   Salud Carlos III (PI14/00638 and PI14/00467) with co-financing from
   European Funds (FEDER), Consejeria de Economia, Innovacion, Ciencia y
   Empleo from the Junta de Andalucia (CVI-7925) and REDINREN from
   Instituto de Salud Carlos III (ISCIII) and EUTOX. This work was also
   supported by PI-0311-2014 Junta de Andalucia and PI12/01866 and EUTOX.
   JR Munoz-Castaneda is a senior researcher supported by the Nicolas
   Monardes Programme, Consejeria de Salud-SAS (Junta de Andalucia).
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NR 21
TC 39
Z9 40
U1 0
U2 9
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD SEP 12
PY 2018
VL 8
AR 13701
DI 10.1038/s41598-018-32065-2
PG 14
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA GT3CK
UT WOS:000444377500021
PM 30209259
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Radman, M
   McGuire, J
   Zimmerman, J
AF Radman, Monique
   McGuire, John
   Zimmerman, Jerry
TI Childhood Obesity, Endothelial Cell Activation, and Critical Illness
SO FRONTIERS IN PEDIATRICS
LA English
DT Review
DE obesity; endothelial; activation; dysfunction; critical illness;
   inflammation; pediatric
ID CARDIOVASCULAR RISK-FACTORS; NITRIC-OXIDE SYNTHASE; BODY-MASS INDEX;
   METABOLIC SYNDROME; OXIDATIVE STRESS; PROGENITOR CELLS; SUBLINGUAL
   MICROCIRCULATION; CARDIOPULMONARY BYPASS; ADHESION MOLECULES; EXERCISE
   CAPACITY
AB Pediatric obesity is increasing in prevalence and is frequently an antecedent to adult obesity and adult obesity-associated morbidities such as atherosclerosis, type II diabetes, and chronic metabolic syndrome. Endothelial cell activation, one aspect of inflammation, is present in the early stages of atherosclerosis, often prior to the onset of symptoms. Endothelial activation is a pathological condition in which vasoconstricting, pro-thrombotic, and proliferative mediators predominate protective vasodilating, anti-thrombogenic, and anti-mitogenic mediators. Many studies report poor outcomes among obese children with systemic endothelial activation. Likewise, the link between childhood obesity and poor outcomes in critical illness is well-established. However, the link between obesity and severity of endothelial activation specifically in the setting of critical illness is largely unstudied. Although endothelial cell activation is believed to worsen disease in critically ill children, the nature and extent of this response is poorly understood due to the difficulty in measuring endothelial cell dysfunction and destruction. Based on the data available for the obese, asymptomatic population and the obese, critically ill population, the authors posit that obesity, and obesity-associated chronic inflammation, including oxidative stress and insulin resistance, may contribute to endothelial activation and associated worse outcomes among critically ill children. A research agenda to examine this hypothesis is suggested.
C1 [Radman, Monique; McGuire, John; Zimmerman, Jerry] Univ Washington, Seattle Childrens Hosp, Pediat Crit Care, Seattle, WA 98195 USA.
C3 University of Washington; University of Washington Seattle; Seattle
   Children's Hospital
RP Radman, M (corresponding author), Univ Washington, Seattle Childrens Hosp, Pediat Crit Care, Seattle, WA 98195 USA.
EM monique.radman@seattlechildrens.org
RI Radman, Monique/JEP-5684-2023
FU Seattle Children's Hospital Department of Critical Care Medicine and
   Seattle Children's Research Institute Indirect Cost Return Allocation
FX Open access publication fees provided by the Seattle Children's Hospital
   Department of Critical Care Medicine and Seattle Children's Research
   Institute Indirect Cost Return Allocation.
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NR 113
TC 7
Z9 7
U1 0
U2 1
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-2360
J9 FRONT PEDIATR
JI Front. Pediatr.
PD AUG 5
PY 2020
VL 8
AR 441
DI 10.3389/fped.2020.00441
PG 9
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA NF4PW
UT WOS:000563280900001
PM 32850554
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU De Couck, M
   Mravec, B
   Gidron, Y
AF De Couck, Marijke
   Mravec, Boris
   Gidron, Yori
TI You may need the vagus nerve to understand pathophysiology and to treat
   diseases
SO CLINICAL SCIENCE
LA English
DT Article
DE Alzheimer's disease; cancer; cardiovascular disease; heart rate
   variability; neuromodulation; vagus nerve
ID HEART-RATE-VARIABILITY; C-REACTIVE PROTEIN; OXIDATIVE STRESS;
   CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; DAMAGE; RISK;
   ATHEROSCLEROSIS; STIMULATION; MODULATION
AB Can different pathophysiological mechanisms and risk factors leading to various diseases be linked with altered transmission of signals by one common pathway? The present article provides evidence for the hypothesis that adequate vagal nerve activity reduces the risk of major diseases, via common basic mechanisms and interim risk factors. These diseases include cardiovascular disease, cancer, Alzheimer's disease and the metabolic syndrome. Three basic mechanisms contribute to such illnesses: local oxidative stress and DNA damage, inflammatory reactions and excessive sympathetic responses, all of which are inhibited by vagal nerve activity. Efferent vagal activity that can be non-invasively measured by HRV (heart rate variability), derived from an ECG, is inversely related to all three basic mechanisms, to various risk factors (e.g. diabetes and dyslipidaemia) and, more broadly, to the diseases as well. Finally, vagal activity is proposed to moderate the effects of risk factors on developing such illnesses. By proposing an integrative neurobiological model of major diseases, identifying people at risk for, and treating patients with, such diseases may be done more efficiently. People with low HRV may be identified and subsequently treated by vagus nerve activation to possibly prevent or treat such illnesses. This proposed disease paradigm may have important preventative and therapeutic implications, whose clinical effects need to be investigated.
C1 [De Couck, Marijke; Gidron, Yori] Vrije Univ Brussel, Fac Med & Pharm, Brussels, Belgium.
   [Mravec, Boris] Comenius Univ, Fac Med, Inst Pathophysiol, Bratislava, Slovakia.
   [Mravec, Boris] Slovak Acad Sci, Inst Expt Endocrinol, Bratislava, Slovakia.
C3 Vrije Universiteit Brussel; Comenius University Bratislava; Slovak
   Academy of Sciences; Institute of Experimental Endocrinology, SAS
RP Gidron, Y (corresponding author), Vrije Univ Brussel, Fac Med & Pharm, Brussels, Belgium.
EM Yori.Gidron@vub.ac.be
OI Mravec, Boris/0000-0002-3177-6819
FU Reliable Cancer Therapies
FX This work was supported by Reliable Cancer Therapies (to Y.G.).
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NR 46
TC 66
Z9 71
U1 0
U2 28
PU PORTLAND PRESS LTD
PI LONDON
PA CHARLES DARWIN HOUSE, 12 ROGER STREET, LONDON WC1N 2JU, ENGLAND
SN 0143-5221
EI 1470-8736
J9 CLIN SCI
JI Clin. Sci.
PD APR
PY 2012
VL 122
IS 7-8
BP 323
EP 328
DI 10.1042/CS20110299
PG 6
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 926JQ
UT WOS:000302827700002
PM 22150254
DA 2025-06-11
ER

PT J
AU Eller, OC
   Morris, EM
   Thyfault, JP
   Christianson, JA
AF Eller, Olivia C.
   Morris, E. Matthew
   Thyfault, John P.
   Christianson, Julie A.
TI Early life stress reduces voluntary exercise and its prevention of
   diet-induced obesity and metabolic dysfunction in mice
SO PHYSIOLOGY & BEHAVIOR
LA English
DT Article
DE Metabolic syndrome; Obesity; Exercise; Early life stress; Diet;
   Inflammation
ID 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1; ADIPOSE-TISSUE;
   INSULIN-RESISTANCE; MATERNAL SEPARATION; BODY-WEIGHT; TREADMILL
   EXERCISE; MATHEMATICAL-MODEL; GLUCOSE-TOLERANCE; MAST-CELLS; FAT INTAKE
AB The development of obesity-related metabolic syndrome (MetS) involves a complex interaction of genetic and environmental factors. One environmental factor found to be significantly associated with MetS is early life stress (ELS). We have previously reported on our mouse model of ELS, induced by neonatal maternal separation (NMS), that displays altered regulation of the hypothalamic-pituitary-adrenal (HPA) axis and increased sensitivity in the urogenital organs, which was attenuated by voluntary wheel running. Here, we are using our NMS model to determine if ELS-induced changes in the HPA axis also influence weight gain and MetS. Naive (non-stressed) and NMS male mice were given free access to a running wheel and a low-fat control diet at 4-weeks of age. At 16-weeks of age, half of the mice were transitioned to a high fat/sucrose (HFS) diet to investigate if NMS influences the effectiveness of voluntary exercise to prevent diet-induced obesity and MetS. Overall, we observed a greater impact of voluntary exercise on prevention of HFS diet-induced outcomes in naive mice, compared to NMS mice. Although body weight and fat mass were still significantly higher, exercise attenuated fasting insulin levels and mRNA levels of inflammatory markers in epididymal adipose tissue in HFS diet-fed naive mice. Only moderate changes were observed in exercised NMS mice on a HFS diet, although this could partially be explained by reduced running distance within this group. Interestingly, sedentary NMS mice on a control diet displayed impaired glucose homeostasis and moderately increased pro-inflammatory mRNA levels in epididymal adipose, suggesting that early life stress alone impairs metabolic function and negatively impacts the therapeutic effect of voluntary exercise.
C1 [Eller, Olivia C.; Christianson, Julie A.] Univ Kansas, Sch Med, Dept Anat & Cell Biol, Med Ctr, Kansas City, KS 66160 USA.
   [Morris, E. Matthew; Thyfault, John P.] Univ Kansas, Sch Med, Dept Mol & Integrat Physiol, Med Ctr, Kansas City, KS 66160 USA.
C3 University of Kansas; University of Kansas Medical Center; University of
   Kansas; University of Kansas Medical Center
RP Christianson, JA (corresponding author), Univ Kansas, Dept Anat & Cell Biol, Med Ctr, 3901 Rainbow Blvd,MS 3038, Kansas City, KS 66160 USA.
EM jchristianson@kumc.edu
RI Eller-Smith, Olivia/IWE-4667-2023; Thyfault, John/JMB-3070-2023
OI Eller, Olivia/0000-0001-7694-855X; Thyfault, John/0000-0001-7920-7466
FU National Institutes of Health (NIH) [R01DK099611, R01DK103872,
   R01AR071263, K01DK112967, T32HD057850]; Idea Network of Biomedical
   Research Excellence (INBRE) Program [P20GM103418]; Kansas IDDRC
   [U54HD090216]; VA Merit Review [1I01BX002567]
FX This work was funded by the National Institutes of Health (NIH) grants
   R01DK099611 (JAC), R01DK103872 (JAC), R01AR071263 (JPT), K01DK112967
   (EMM), T32HD057850 (OCE), P20GM103418 (Idea Network of Biomedical
   Research Excellence (INBRE) Program), U54HD090216 (Kansas IDDRC), and VA
   Merit Review 1I01BX002567 (JPT).
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NR 80
TC 18
Z9 18
U1 0
U2 13
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0031-9384
J9 PHYSIOL BEHAV
JI Physiol. Behav.
PD SEP 1
PY 2020
VL 223
AR 113000
DI 10.1016/j.physbeh.2020.113000
PG 10
WC Psychology, Biological; Behavioral Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Behavioral Sciences
GA MN0ZU
UT WOS:000550576800040
PM 32512033
OA Green Submitted, Green Accepted
DA 2025-06-11
ER

PT J
AU Thörn, K
   Hovsepyan, M
   Bergsten, P
AF Thorn, Kristofer
   Hovsepyan, Meri
   Bergsten, Peter
TI Reduced levels of SCD1 accentuate palmitate-induced stress in
   insulin-producing β-cells
SO LIPIDS IN HEALTH AND DISEASE
LA English
DT Article
ID STEAROYL-COA DESATURASE-1; ENDOPLASMIC-RETICULUM STRESS; COENZYME-A
   DESATURASE; FATTY-ACID OXIDATION; PROTECTS MICE; EXPRESSION; MUSCLE;
   SENSITIVITY; INHIBITORS; APOPTOSIS
AB Background: Stearoyl-CoA desaturase 1 (SCD1) is an ER resident enzyme introducing a double-bond in saturated fatty acids. Global knockout of SCD1 in mouse increases fatty acid oxidation and insulin sensitivity which makes the animal resistant to diet-induced obesity. Inhibition of SCD1 has therefore been proposed as a potential therapy of the metabolic syndrome. Much of the work has focused on insulin target tissue and very little is known about how reduced levels of SCD1 would affect the insulin-producing beta-cell, however. The aim of the present study was therefore to investigate how reduced levels of SCD1 affect the beta-cell.
   Results: Insulin-secreting MIN6 cells with reduced levels of SCD1 were established by siRNA mediated knockdown. When fatty acid oxidation was measured, no difference between cells with reduced levels of SCD1 and mock-transfected cells were found. Also, reducing levels of SCD1 did not affect insulin secretion in response to glucose. To investigate how SCD1 knockdown affected cellular mechanisms, differentially regulated proteins were identified by a proteomic approach. Cells with reduced levels of SCD1 had higher levels of ER chaperones and components of the proteasome. The higher amounts did not protect the beta-cell from palmitate-induced ER stress and apoptosis. Instead, rise in levels of p-eIF2 alpha and CHOP after palmitate exposure was 2-fold higher in cells with reduced levels of SCD1 compared to mock-transfected cells. Accordingly, apoptosis rose to higher levels after exposure to palmitate in cells with reduced levels of SCD1 compared to mock-transfected cells.
   Conclusions: In conclusion, reduced levels of SCD1 augment palmitate-induced ER stress and apoptosis in the beta-cell, which is an important caveat when considering targeting this enzyme as a treatment of the metabolic syndrome.
C1 [Thorn, Kristofer; Hovsepyan, Meri; Bergsten, Peter] Uppsala Univ, Dept Med Cell Biol, S-75123 Uppsala, Sweden.
   [Hovsepyan, Meri] Armenian Natl Acad Sci, Inst Mol Biol, Yerevan 0014, Armenia.
C3 Uppsala University; National Academy of Sciences of Armenia; Institute
   of Molecular Biology - NAS RA
RP Thörn, K (corresponding author), Uppsala Univ, Dept Med Cell Biol, BMC Box 571, S-75123 Uppsala, Sweden.
EM kristofer.thorn@mcb.uu.se
FU Swedish Medical Research Council [72X-14019]; European Foundation for
   the Study of Diabetes; Swedish Diabetes Association; Swedish Medical
   Association; Family Ernfors Fund
FX This work was supported by grants from the Swedish Medical Research
   Council (72X-14019), the European Foundation for the Study of Diabetes,
   the Swedish Diabetes Association, the Swedish Medical Association and
   Family Ernfors Fund.
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NR 32
TC 35
Z9 39
U1 0
U2 11
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1476-511X
J9 LIPIDS HEALTH DIS
JI Lipids Health Dis.
PD SEP 29
PY 2010
VL 9
AR 108
DI 10.1186/1476-511X-9-108
PG 8
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA 667EC
UT WOS:000283174500001
PM 20920255
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Slyepchenko, A
   Maes, M
   Jacka, FN
   Köhler, CA
   Barichello, T
   McIntyre, RS
   Berk, M
   Grande, I
   Foster, JA
   Vieta, E
   Carvalho, AF
AF Slyepchenko, Anastasiya
   Maes, Michael
   Jacka, Felice N.
   Koehler, Cristiano A.
   Barichello, Tatiana
   McIntyre, Roger S.
   Berk, Michael
   Grande, Iria
   Foster, Jane A.
   Vieta, Eduard
   Carvalho, Andre F.
TI Gut Microbiota, Bacterial Translocation, and Interactions with Diet:
   Pathophysiological Links between Major Depressive Disorder and Non
   Communicable Medical Comorbidities
SO PSYCHOTHERAPY AND PSYCHOSOMATICS
LA English
DT Article
DE Mood disorders; Obesity; Depression; Diabetes; Microbiota; Chronic
   fatigue syndrome; Inflammation; Psychiatry; Irritable bowel syndrome;
   Oxidative stress
ID IRRITABLE-BOWEL-SYNDROME; CHRONIC-FATIGUE-SYNDROME; GRAM-NEGATIVE
   ENTEROBACTERIA; MESENTERIC LYMPH-NODES; C-REACTIVE PROTEIN; NITROSATIVE
   STRESS; OXIDATIVE STRESS; ADIPOSE-TISSUE; IMMUNE-SYSTEM; METABOLIC
   SYNDROME
AB Background: Persistent low-grade immune-inflammatory processes, oxidative and nitrosative stress (O&NS), and hypothalamic-pituitary-adrenal axis activation are integral to the pathophysiology of major depressive disorder (MDD). The microbiome, intestinal compositional changes, and resultant bacterial translocation add a new element to the bidirectional interactions of the gut -brain axis; new evidence implicates these pathways in the patho-aetiology of MDD. In addition, abnormalities in the gut-brain axis are associated with several chronic non-communicable disorders, which frequently co-occur in individuals with MDD, including but not limited to irritable bowel syndrome (IBS), chronic fatigue syndrome (CFS), obesity, and type 2 diabetes mellitus (T2DM). Methods: We searched the PubMed/MEDLINE database up until May 1, 2016 for studies which investigated intestinal dysbiosis and bacterial translocation (the 'leaky gut') in the pathophysiology of MDD and co-occurring somatic comorbidities with an emphasis on IBS, CFS, obesity, and T2DM. Results: The composition of the gut microbiota is influenced by several genetic and environmental factors (e.g. diet). Several lines of evidence indicate that gut-microbiotadiet interactions play a significant pathophysiological role in MDD and related medical comorbidities. Gut dysbiosis and the leaky gut may influence several pathways implicated in the biology of MDD, including but not limited to immune activation, O&NS, and neuroplasticity cascades. However, methodological inconsistencies and limitations limit comparisons across studies. Conclusions: Intestinal dysbiosis and the leaky gut may constitute a key pathophysiological link between MDD and its medical comorbidities. This emerging literature opens relevant preventative and therapeutic perspectives. (C) 2016 S. Karger AG, Basel
C1 [Slyepchenko, Anastasiya] McMaster Univ, McMaster Integrat Neurosci Discovery & Study MiND, Hamilton, ON, Canada.
   [Maes, Michael; Jacka, Felice N.; Berk, Michael] Deakin Univ, Sch Med & Barwon Hlth, IMPACT Strateg Res Ctr, Geelong, Vic, Australia.
   [Maes, Michael] Chulalongkorn Univ, Dept Psychiat, Fac Med, Bangkok, Thailand.
   [Maes, Michael] Univ Estadual Londrina, Dept Psychiat, Fac Med, Londrina, Brazil.
   [Maes, Michael] Med Univ Plovdiv, Dept Psychiat, Plovdiv, Bulgaria.
   [Maes, Michael] Revitalis, Waalre, Netherlands.
   [Jacka, Felice N.] Univ Melbourne, Dept Psychiat, Parkville, Vic, Australia.
   [Jacka, Felice N.] Murdoch Childrens Res Inst, Ctr Adolescent Hlth, Melbourne, Vic, Australia.
   [Jacka, Felice N.] Black Dog Inst, Sydney, NSW, Australia.
   [Koehler, Cristiano A.; Carvalho, Andre F.] Univ Fed Ceara, Dept Clin Med, Fortaleza, Ceara, Brazil.
   [Koehler, Cristiano A.] Univ Fed Ceara, Translat Psychiat Res Grp, Fac Med, Fortaleza, Ceara, Brazil.
   [Barichello, Tatiana] Univ Texas Hlth Sci Ctr Houston UTHlth, McGovern Med Sch, Dept Psychiat & Behav Sci, Translat Psychiat Program, Houston, TX USA.
   [McIntyre, Roger S.] Univ Toronto, Univ Hlth Network, Dept Psychiat, Mood Disorder Psychopharmacol Unit, Toronto, ON, Canada.
   [Berk, Michael] Univ Melbourne, Orygen, Natl Ctr Excellence Youth Mental Hlth, Dept Psychiat, Parkville, Vic, Australia.
   [Berk, Michael] Univ Melbourne, Ctr Youth Mental Hlth, Dept Psychiat, Parkville, Vic, Australia.
   [Berk, Michael] Univ Melbourne, Florey Inst Neurosci & Mental Hlth, Parkville, Vic, Australia.
   [Grande, Iria; Vieta, Eduard] Univ Barcelona, CIBERSAM, IDIBAPS, Bipolar Disorder Unit,Inst Neurosci,Hosp Clin, Barcelona, Spain.
   [Foster, Jane A.] McMaster Univ, Brain Body Inst, St Josephs Healthcare, Dept Psychiat & Behav Neurosci, Hamilton, ON, Canada.
C3 McMaster University; Deakin University; Chulalongkorn University;
   Universidade Estadual de Londrina; Medical University Plovdiv;
   University of Melbourne; Murdoch Children's Research Institute; Black
   Dog Institute; Universidade Federal do Ceara; Universidade Federal do
   Ceara; University of Texas System; University of Texas Health Science
   Center Houston; Baylor College of Medicine; Baylor College Medical
   Hospital; University of Toronto; University Health Network Toronto;
   Orygen, The National Centre of Excellence in Youth Mental Health;
   University of Melbourne; University of Melbourne; Orygen, The National
   Centre of Excellence in Youth Mental Health; Florey Institute of
   Neuroscience & Mental Health; University of Melbourne; University of
   Barcelona; Hospital Clinic de Barcelona; IDIBAPS; CIBER - Centro de
   Investigacion Biomedica en Red; CIBERSAM; McMaster University
RP Carvalho, AF (corresponding author), Univ Fed Ceara, Dept Clin Med, Fac Med, Rua Prof Costa Mendes 1608,4 Andar, BR-60430040 Fortaleza, CE, Brazil.
EM andrefc7@terra.com.br
RI McIntyre, Roger/AAU-1000-2020; Grande, Iria/AAF-9342-2021; Foster,
   Jane/AAW-7163-2021; Slyepchenko, Anastasiya/AAK-6000-2021; Jacka,
   Felice/ABE-6322-2020; Barichello, Tatiana/E-2725-2013; Berk,
   Michael/AGH-9427-2022; Carvalho, Andre/AEZ-4001-2022; Vieta,
   Eduard/Y-2919-2019; Maes, Michael/B-8546-2011; Berk,
   Michael/M-7891-2013; Vieta, Eduard/I-6330-2013
OI Berk, Michael/0000-0002-5554-6946; Maes, Michael/0000-0002-2012-871X;
   Vieta, Eduard/0000-0002-0548-0053; Foster, Jane/0000-0002-8579-4705;
   Barichello, Tatiana/0000-0001-7776-8454; Slyepchenko,
   Anastasiya/0000-0003-0179-2129
FU CAPES (Brazil); National Health and Medical Research Council (NHMRC)
   Senior Principal Research Fellowship [1059660]; Juan Rodes research
   contract at the Instituto de Salud Carlos III, Spanish Ministry of
   Economy and Competiveness, Barcelona (Spain) [JR15/00012]; Instituto de
   Salud Carlos III; Spanish Ministry of Economy and Competiveness;
   CIBERSAM [PI12/00912]; Grups Consolidats de Recerca [SGR 398]; Seventh
   European Framework Programme (ENBREC); Stanley Medical Research
   Institute; CNPq (Brazil)
FX C.A.K. is supported by a postdoctoral research fellowship from CAPES
   (Brazil). M.B. is supported by a National Health and Medical Research
   Council (NHMRC) Senior Principal Research Fellowship (1059660). I.G. has
   received a Juan Rodes research contract (JR15/00012) at the Instituto de
   Salud Carlos III, Spanish Ministry of Economy and Competiveness,
   Barcelona (Spain). E.V. thanks the Instituto de Salud Carlos III,
   Spanish Ministry of Economy and Competiveness, CIBERSAM (PI12/00912),
   the Grups Consolidats de Recerca 2014 (SGR 398), the Seventh European
   Framework Programme (ENBREC), and the Stanley Medical Research Institute
   for their support. A.F.C. is supported by a research fellowship award
   from CNPq (Brazil).
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NR 204
TC 181
Z9 198
U1 0
U2 138
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0033-3190
EI 1423-0348
J9 PSYCHOTHER PSYCHOSOM
JI Psychother. Psychosom.
PY 2017
VL 86
IS 1
BP 31
EP 46
DI 10.1159/000448957
PG 16
WC Psychiatry; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry; Psychology
GA EF1KL
UT WOS:000390083600005
PM 27884012
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Torghabeh, FD
   Javadi, B
   Sahebkar, A
AF Torghabeh, Fatemeh Dehbashizadeh
   Javadi, Behjat
   Sahebkar, Amirhossein
TI Dietary anethole: a systematic review of its protective effects against
   metabolic syndrome
SO JOURNAL OF DIABETES AND METABOLIC DISORDERS
LA English
DT Review
DE Metabolic syndrome; Dietary anethole; Obesity; Diabetes; Dyslipidemia;
   Systematic review
ID TRANS-ANETHOLE; INSULIN-RESISTANCE; OXIDATIVE STRESS;
   CARDIOVASCULAR-DISEASE; HYPERTENSION; IMPACT
AB BackgroundMetabolic syndrome (MetS) is a cluster of physiological, biochemical, clinical, and metabolic conditions that aggravate the risk of severe diseases such as cardiovascular disease, type 2 diabetes mellitus, and fatty liver. Several dietary molecules have been considered preventive compounds for MetS. Anethole, a natural phenylpropanoid, has been found to protect against MetS and its associated components.AimThis systematic review aims to provide an overview of the preclinical evidence supporting the protective effects of dietary anethole against MetS and the associated diseases.MethodsA literature search was performed using Web of Sciences, PubMed, Scopus, and Google Scholar to identify studies reporting the protective effects of dietary anethole against MetS, without any time restrictions. Review articles, letters to editors, editorials, unpublished results, and non-English papers were excluded from the study.ResultsThe results showed that anethole has the potential to effectively protect against the key features of MetS via various mechanisms, including antioxidant and anti-inflammatory effects, stimulating insulin secretion from beta-cells, mediating oxidative stress, modulation of the mTOR/PPAR gamma axis, arterial remodeling, and improvement of vascular relaxation.ConclusionAnethole modulates several molecular pathways that are implicated in the pathogenesis of MetS. Future in vitro and animal investigations should be conducted to explore other anti-MetS signaling pathways of anethole. Additionally, well-designed clinical studies are warranted to determine the optimal human dose, bioavailability, and pharmacokinetic characteristics of this dietary compound.
C1 [Torghabeh, Fatemeh Dehbashizadeh; Javadi, Behjat] Mashhad Univ Med Sci, Sch Pharm, Dept Tradit Pharm, Mashhad, Iran.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Biotechnol Res Ctr, Mashhad, Iran.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Appl Biomed Res Ctr, Mashhad, Iran.
C3 Mashhad University of Medical Sciences; Mashhad University of Medical
   Sciences; Mashhad University of Medical Sciences
RP Sahebkar, A (corresponding author), Mashhad Univ Med Sci, Pharmaceut Technol Inst, Biotechnol Res Ctr, Mashhad, Iran.; Sahebkar, A (corresponding author), Mashhad Univ Med Sci, Appl Biomed Res Ctr, Mashhad, Iran.
EM amir_saheb2000@yahoo.com
RI Sahebkar, Amirhossein/B-5124-2018; Javadi, Behjat/AAC-5468-2020
FU Research Council of Mashhad University of Medical Sciences; Mashhad
   University of Medical Sciences
FX The authors would like to thank Mashhad University of Medical Sciences
   for supporting the present study.
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NR 59
TC 3
Z9 3
U1 0
U2 3
PU SPRINGER INT PUBL AG
PI CHAM
PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND
EI 2251-6581
J9 J DIABETES METAB DIS
JI J. Diabetes Metab. Disord.
PD JUN
PY 2024
VL 23
IS 1
BP 619
EP 631
DI 10.1007/s40200-023-01322-1
EA DEC 2023
PG 13
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA I8H6K
UT WOS:001131885500001
PM 38932801
DA 2025-06-11
ER

PT J
AU Reverri, EJ
   Randolph, JM
   Steinberg, FM
   Kappagoda, CT
   Edirisinghe, I
   Burton-Freeman, BM
AF Reverri, Elizabeth J.
   Randolph, Jody M.
   Steinberg, Francene M.
   Kappagoda, C. Tissa
   Edirisinghe, Indika
   Burton-Freeman, Britt M.
TI Black Beans, Fiber, and Antioxidant Capacity Pilot Study: Examination of
   Whole Foods vs. Functional Components on Postprandial Metabolic,
   Oxidative Stress, and Inflammation in Adults with Metabolic Syndrome
SO NUTRIENTS
LA English
DT Article
ID HIGH-FAT; NONFASTING TRIGLYCERIDES; HEART-DISEASE; ENDOTHELIAL FUNCTION;
   INSULIN SENSITIVITY; PHASEOLUS-VULGARIS; HIGH-CARBOHYDRATE;
   HEALTHY-SUBJECTS; DIETARY FIBER; OLIVE OIL
AB Beans (Phaseolus vulgaris) contain bioactive components with functional properties that may modify cardiovascular risk. The aims of this pilot study were to evaluate the ability of black beans to attenuate postprandial metabolic, oxidative stress, and inflammatory responses and determine relative contribution of dietary fiber and antioxidant capacity of beans to the overall effect. In this randomized, controlled, crossover trial, 12 adults with metabolic syndrome (MetS) consumed one of three meals (black bean (BB), fiber matched (FM), and antioxidant capacity matched (AM)) on three occasions that included blood collection before (fasting) and five hours postprandially. Insulin was lower after the BB meal, compared to the FM or AM meals (p < 0.0001). A significant meal x time interaction was observed for plasma antioxidant capacity (p = 0.002) revealing differences over time: AM > BB > FM. Oxidized LDL (oxLDL) was not different by meal, although a trend for declining oxLDL was observed after the BB and AM meals at five hours compared to the FM meal. Triglycerides and interleukin-6 (IL-6) increased in response to meals (p < 0.0001). Inclusion of black beans with a typical Western-style meal attenuates postprandial insulin and moderately enhances postprandial antioxidant endpoints in adults with MetS, which could only be partly explained by fiber content and properties of antioxidant capacity.
C1 [Reverri, Elizabeth J.; Randolph, Jody M.; Steinberg, Francene M.; Burton-Freeman, Britt M.] Univ Calif Davis, Dept Nutr, Davis, CA 95616 USA.
   [Kappagoda, C. Tissa] Univ Calif Davis, Davis Hlth Syst, Lawrence J Ellis Ambulatory Care Ctr, Dept Cardiovasc Med, Sacramento, CA 95817 USA.
   [Kappagoda, C. Tissa] Univ Calif Davis, Davis Hlth Syst, Lawrence J Ellis Ambulatory Care Ctr, Dept Cardiol, Sacramento, CA 95817 USA.
   [Kappagoda, C. Tissa] Univ Calif Davis, Davis Hlth Syst, Lawrence J Ellis Ambulatory Care Ctr, Dept Internal Med, Sacramento, CA 95817 USA.
   [Edirisinghe, Indika; Burton-Freeman, Britt M.] IIT, Inst Food Safety & Hlth, Ctr Nutr Res, Bedford Pk, IL 60501 USA.
C3 University of California System; University of California Davis;
   University of California System; University of California Davis;
   University of California System; University of California Davis;
   University of California System; University of California Davis;
   Illinois Institute of Technology
RP Burton-Freeman, BM (corresponding author), Univ Calif Davis, Dept Nutr, One Shields Ave, Davis, CA 95616 USA.
EM ebjordan@ucdavis.edu; jmrandolph@ucdavis.edu; fmsteinberg@ucdavis.edu;
   iedirisi@iit.edu; bburton@iit.edu
RI Reverri, Elizabeth/H-3840-2014
OI Reverri, Elizabeth/0000-0001-7692-0901
FU USDA Agricultural Research Service (CRIS) [CA-D*NTR-6316-H]; UC Davis
   Jastro Research Award [GGNBEJ3]; US Dry Bean Council
FX Study funding was provided by the USDA Agricultural Research Service
   (CRIS # CA-D*NTR-6316-H), UC Davis Jastro Research Award (grant number
   GGNBEJ3), and US Dry Bean Council. Polyphenolics donated GSE lot
   20392508-1.
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NR 57
TC 50
Z9 52
U1 1
U2 33
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD AUG
PY 2015
VL 7
IS 8
BP 6139
EP 6154
DI 10.3390/nu7085273
PG 16
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA CQ4PQ
UT WOS:000360587500006
PM 26225995
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Kyrou, L
   Tsigos, C
AF Kyrou, Loannis
   Tsigos, Constantine
TI Chronic stress, visceral obesity and gonadal dysfunction
SO HORMONES-INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM
LA English
DT Review
DE Abdominal obesity; Adipokines; Gonads; Hypogonadism;
   Hypothalamic-pituitary-adrenal axis; Obesity; Sex-steroids; Stress
ID RECOMBINANT HUMAN INTERLEUKIN-6; HORMONE GENE-EXPRESSION;
   NECROSIS-FACTOR-ALPHA; ADIPOSE-TISSUE; METABOLIC SYNDROME; LEPTIN;
   REPRODUCTION; INFLAMMATION; IMPACT; ENDOCRINOLOGY
AB Chronic stress represents a prolonged state of dyshomeostasis caused by intense and frequently imposed stressors. Obesity constitutes a chronic dysmetabolic state, leading progressively to a spectrum of metabolic complications, such as diabetes, dyslipidemia, hypertension and cardiovascular disease. A growing body of evidence supports the existence of significant interactions between stress and obesity, with chronic stress promoting weight gain, and consequently excessive fat accumulation especially visceral, all these factors contributing to the development of a chronic stressful state. Maintaining body homeostasis is a prerequisite for normal reproductive function, which is vital for the survival of the species and an important process of natural selection. Under chronic stress, reproductive function is suspended and disrupted due to central and peripheral actions of hormones, adipokines and pro-inflammatory cytokines that inhibit the activity of the hypothalamic-pituitary gonadal (HPG) axis at various levels. Clinical and experimental data link both obesity and chronic stress to dysregulation of the gonadal axis, via independent and synergistic mechanisms, which may chronically lead to reproductive dysfunction and reduced fertility.
C1 [Kyrou, Loannis; Tsigos, Constantine] Univ Athens, Sch Med, Evgenid Hosp, Endocrinol Metab & Diabet Unit, GR-11527 Athens, Greece.
   [Kyrou, Loannis] Univ Warwick, Warwick Med Sch, Univ Hosp Coventry, WISDEM,Unit Diabet & Metab, Coventry CV4 7AL, W Midlands, England.
   [Kyrou, Loannis] Univ Warwick, Warwick Med Sch, Univ Hosp Warwickshire, WISDEM,Unit Diabet & Metab, Coventry CV4 7AL, W Midlands, England.
C3 Athens Medical School; National & Kapodistrian University of Athens;
   University of Warwick; University of Warwick
RP Tsigos, C (corresponding author), 82 Vas Sophias Ave, GR-11528 Athens, Greece.
EM ctsigos@gmail.com
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NR 53
TC 47
Z9 53
U1 0
U2 11
PU SPRINGER INTERNATIONAL PUBLISHING AG
PI CHAM
PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND
SN 1109-3099
EI 2520-8721
J9 HORM-INT J ENDOCRINO
JI Horm.-Int. J. Endocrinol. Metab.
PD OCT-DEC
PY 2008
VL 7
IS 4
BP 287
EP 293
DI 10.14310/horm.2002.1209
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 381VU
UT WOS:000261564800001
PM 19121989
OA Bronze
DA 2025-06-11
ER

PT J
AU Quesada, I
   Cejas, J
   García, R
   Cannizzo, B
   Redondo, A
   Castro, C
AF Quesada, Isabel
   Cejas, Jimena
   Garcia, Rodrigo
   Cannizzo, Beatriz
   Redondo, Analia
   Castro, Claudia
TI Vascular dysfunction elicited by a cross talk between periaortic adipose
   tissue and the vascular wall is reversed by pioglitazone
SO CARDIOVASCULAR THERAPEUTICS
LA English
DT Article
DE adipose tissue; atherosclerosis; oxidative stress; pioglitazone
ID PROLIFERATOR-ACTIVATED RECEPTOR; TYPE-2 DIABETES-MELLITUS; NADPH OXIDASE
   ACTIVITY; ENDOTHELIAL DYSFUNCTION; PPAR-GAMMA; CAROTID ATHEROSCLEROSIS;
   CARDIOVASCULAR-DISEASE; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   OXIDATIVE STRESS
AB Aim: Perivascular adipose tissue (PVAT) is in intimate contact with the vessel wall and extravascular PVAT-derived inflammatory mediators may adversely influence atherosclerotic plaque formation and stability through outside-to-inside signaling. We sought to investigate the role of PVAT on the atheroma development in an experimental animal model of metabolic syndrome (MS) associated with oxidative stress and low-grade inflammatory state. We also studied the effect of pioglitazone an insulin sensitizer, on the aortic wall and its surrounding PVAT, considering a bi-directional communication between both layers.
   Methods: Apolipoprotein E-deficient mice (ApoE(-/-)) were fed with standard diet (CD, control diet) or fructose overload (10% w/v) (FD, fructose diet) for 8weeks and treated with or without pioglitazone the latest 4weeks.
   Results: Biochemical variables show that glycemia and lipid peroxidation determined by thiobarbituric acid reactive species (TBARS) significantly increased in FD-fed ApoE(-/-) mice. FD significantly increased aortic PVAT expression of oxidative stress associated genes: p22(phox), Nox1, Nox2, Nox4 and p47(phox), and proinflammatory genes: Visfatin, MCP-1, and MMP-9. Pioglitazone diminished PVAT-oxidative damage elicited by fructose treatment and markedly down-regulated proinflammatory markers. Even pioglitazone did not prevent the development of the aortic atheroma plaques stimulated by FD, significantly diminished VCAM-1 expression, MMP-9 expression and activity in aortic media wall and significantly reduced the accumulation of lipids and macrophages in atheroma plaques.
   Conclusion: Our results support the fact that PVAT contributes to the development and progression of cardiovascular disease by underlying mechanisms elicited by outside-in signaling. Treatment with pioglitazone may offer a new effect on the whole vessel wall, promoting the stability of advanced atherosclerotic plaques.
C1 [Quesada, Isabel; Cejas, Jimena; Cannizzo, Beatriz; Redondo, Analia; Castro, Claudia] Natl Univ Cuyo, Vasc Biol Lab, Inst Expt Med & Biol Cuyo IMBECU, CONICET,Sch Med Sci, Mendoza, Argentina.
   [Garcia, Rodrigo] Consejo Nacl Invest Cient & Tecn, Lab Cardiovasc Physiopathol, Inst Expt Med & Biol Cuyo IMBECU, Mendoza, Argentina.
   [Cannizzo, Beatriz] Genzyme Argentina AS, Boulogne, Argentina.
C3 Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET);
   Instituto de Medicina y BiologIa Experimental de Cuyo (IMBECU);
   University Nacional Cuyo Mendoza; Consejo Nacional de Investigaciones
   Cientificas y Tecnicas (CONICET); Instituto de Medicina y BiologIa
   Experimental de Cuyo (IMBECU)
RP Castro, C (corresponding author), Consejo Nacl Invest Cient & Tecn, Inst Expt Med & Biol Cuyo IMBECU, Mendoza, Argentina.
EM ccastro@fcm.uncu.edu.ar
RI GARCIA, RODRIGO DAMIAN/IUN-1823-2023
OI Castro, Claudia/0000-0002-8428-2484; Garcia, Rodrigo
   Damian/0000-0002-6654-214X
FU Secretary of Science and Technology [06/J431]; National University of
   Cuyo; PIP-CONICET; CONICET
FX This work was supported by grant 06/J431 2013-2015 from Secretary of
   Science and Technology, National University of Cuyo, and PIP-CONICET
   2012-2014 (to C Castro). JC is a recipient of a fellowship from National
   University of Cuyo and RG, BC, and AR were granted by a doctoral
   fellowship from CONICET.
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NR 38
TC 27
Z9 29
U1 2
U2 12
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1755-5914
EI 1755-5922
J9 CARDIOVASC THER
JI Cardiovasc. Ther.
PD JUN
PY 2018
VL 36
IS 3
AR e12322
DI 10.1111/1755-5922.12322
PG 9
WC Cardiac & Cardiovascular Systems; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Pharmacology & Pharmacy
GA GF4ZL
UT WOS:000431973600002
PM 29464937
OA Green Published
DA 2025-06-11
ER

PT J
AU Esteves, CL
   Kelly, V
   Bégay, V
   Man, TY
   Morton, NM
   Leutz, A
   Seckl, JR
   Chapman, KE
AF Esteves, Cristina L.
   Kelly, Val
   Begay, Valerie
   Man, Tak Y.
   Morton, Nicholas M.
   Leutz, Achim
   Seckl, Jonathan R.
   Chapman, Karen E.
TI Regulation of Adipocyte 11β-Hydroxysteroid Dehydrogenase Type 1
   (11β-HSD1) by CCAAT/Enhancer-Binding Protein (C/EBP) β Isoforms, LIP and
   LAP
SO PLOS ONE
LA English
DT Article
ID ENDOPLASMIC-RETICULUM STRESS; TRANSCRIPTIONAL INHIBITORY PROTEIN;
   ADIPOSE-TISSUE; GENE-TRANSCRIPTION; METABOLIC SYNDROME;
   GLUCOSE-PRODUCTION; VISCERAL OBESITY; MICE; EXPRESSION; ALPHA
AB 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1) catalyses intracellular regeneration of active glucocorticoids, notably in liver and adipose tissue. 11 beta-HSD1 is increased selectively in adipose tissue in human obesity, a change implicated in the pathogenesis of metabolic syndrome. With high fat (HF)-feeding, adipose tissue 11 beta-HSD1 is down-regulated in mice, plausibly to counteract metabolic disease. Transcription of 11 beta-HSD1 is directly regulated by members of the CCAAT/enhancer binding protein (C/EBP) family. Here we show that while total C/EBP beta in adipose tissue is unaltered by HF diet, the ratio of the C/EBP beta isoforms liver-enriched inhibitor protein (LIP) and liver-enriched activator protein (LAP) (C/EBP beta-LIP:LAP) is increased in subcutaneous adipose. This may cause changes in 11 beta-HSD1 expression since genetically modified C/EBP beta((+/L)) mice, with increased C/EBP beta-LIP:LAP ratio, have decreased subcutaneous adipose 11 beta-HSD1 mRNA levels, whereas C/EBP beta(Delta uORF) mice, with decreased C/EBP beta-LIP:LAP ratio, show increased subcutaneous adipose 11 beta-HSD1. C/EBP beta-LIP:LAP ratio is regulated by endoplasmic reticulum (ER) stress and mTOR signalling, both of which are altered in obesity. In 3T3-L1 adipocytes, 11 beta-HSD1 mRNA levels were down-regulated following induction of ER stress by tunicamycin but were up-regulated following inhibition of mTOR by rapamycin. These data point to a central role for C/EBP beta and its processing to LIP and LAP in transcriptional regulation of 11 beta-HSD1 in adipose tissue. Down-regulation of 11 beta-HSD1 by increased C/EBP beta-LIP:LAP in adipocytes may be part of a nutrient-sensing mechanism counteracting nutritional stress generated by HF diet.
C1 [Esteves, Cristina L.; Kelly, Val; Man, Tak Y.; Seckl, Jonathan R.; Chapman, Karen E.] Univ Edinburgh, Queens Med Res Inst, Univ BHF Ctr Cardiovasc Sci, Endocrinol Unit, Edinburgh, Midlothian, Scotland.
   [Morton, Nicholas M.] Univ Edinburgh, Queens Med Res Inst, Univ BHF Ctr Cardiovasc Sci, Mol Metab Grp, Edinburgh, Midlothian, Scotland.
   [Begay, Valerie; Leutz, Achim] Max Delbrueck Ctr Mol Med, Berlin, Germany.
C3 University of Edinburgh; University of Edinburgh; Helmholtz Association;
   Max Delbruck Center for Molecular Medicine
RP Esteves, CL (corresponding author), Univ Edinburgh, Queens Med Res Inst, Univ BHF Ctr Cardiovasc Sci, Endocrinol Unit, Edinburgh, Midlothian, Scotland.
EM Karen.Chapman@ed.ac.uk
RI Seckl, Jonathan/C-3555-2013; Esteves, Cristina/Y-5577-2019; Morton,
   NICHOLAS/ABF-3774-2020; Leutz, Achim/K-9643-2013
OI Leutz, Achim/0000-0001-8259-927X; Chapman, Karen/0000-0001-7777-6817
FU Wellcome Trust Programme Grant [WT083184]; Wellcome Trust Career
   Development Fellowship [079660/z/06/z]; Wellcome Trust [079660/Z/06/Z]
   Funding Source: Wellcome Trust
FX This work was supported by a Wellcome Trust Programme Grant (grant
   number WT083184 to JRS and KEC). NMM was funded by a Wellcome Trust
   Career Development Fellowship (grant 079660/z/06/z). The funders had no
   role in study design, data collection and analysis, decision to publish,
   or preparation of the manuscript.
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NR 44
TC 20
Z9 22
U1 0
U2 7
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAY 25
PY 2012
VL 7
IS 5
AR e37953
DI 10.1371/journal.pone.0037953
PG 10
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 959UY
UT WOS:000305342300145
PM 22662254
OA Green Published, Green Submitted, Green Accepted, gold
DA 2025-06-11
ER

PT J
AU Brunner, EJ
   Hemingway, H
   Walker, BR
   Page, M
   Clarke, P
   Juneja, M
   Shipley, MJ
   Kumari, M
   Andrew, R
   Seckl, JR
   Papadopoulos, A
   Checkley, S
   Rumley, A
   Lowe, GDO
   Stansfeld, SA
   Marmot, MG
AF Brunner, EJ
   Hemingway, H
   Walker, BR
   Page, M
   Clarke, P
   Juneja, M
   Shipley, MJ
   Kumari, M
   Andrew, R
   Seckl, JR
   Papadopoulos, A
   Checkley, S
   Rumley, A
   Lowe, GDO
   Stansfeld, SA
   Marmot, MG
TI Adrenocortical, autonomic, and inflammatory causes of the metabolic
   syndrome - Nested case-control study
SO CIRCULATION
LA English
DT Article
DE norepinephrine; coronary disease; stress; metabolism; heart rate
ID CORONARY-HEART-DISEASE; INSULIN-RESISTANCE; ATHEROSCLEROSIS RISK;
   RATE-VARIABILITY; STRESS; CORTISOL; OBESITY; DETERMINANTS; FIBRINOLYSIS;
   INEQUALITIES
AB Background-The causes of metabolic syndrome (MS), which may be a precursor of coronary disease, are uncertain. We hypothesize that disturbances in neuroendocrine and cardiac autonomic activity (CAA) contribute to development of MS. We examine reversibility and the power of psychosocial and behavioral factors to explain the neuroendocrine adaptations that accompany MS.
   Methods and Results-This was a double-blind case-control study of working men aged 45 to 63 years drawn from the Whitehall II cohort. MS cases (n = 30) were compared with healthy controls (n = 153). Cortisol secretion, sensitivity, and 24-hour cortisol metabolite and catecholamine output were measured over 2 days. CAA was obtained from power spectral analysis of heart rate variability (HRV) recordings. Twenty-four-hour cortisol metabolite and normetanephrine (3-methoxynorepinephrine) outputs were higher among cases than controls (+0.49, +0.45 SD, respectively). HRV and total power were lower among cases (both -0.72 SD). Serum interleukin-6, plasma C-reactive protein, and viscosity were higher among cases (+0.89, +0.51, and +0.72 SD). Lower HRV was associated with higher normetanephrine output (r=-0.19; P=0.03). Among former cases (MS 5 years previously, n=23), cortisol output, heart rate, and interleukin-6 were at the level of controls. Psychosocial factors accounted for 37% of the link between MS and normetanephrine output, and 7% to 19% for CAA. Health-related behaviors accounted for 5% to 18% of neuroendocrine differences.
   Conclusions-Neuroendocrine stress axes are activated in MS. There is relative cardiac sympathetic predominance. The neuroendocrine changes may be reversible. This case-control study provides the first evidence that chronic stress may be a cause of MS. Confirmatory prospective studies are required.
C1 UCL, Dept Epidemiol & Publ Hlth, Int Ctr Hlth & Society, London, England.
   Univ Edinburgh, Western Gen Hosp, Endocrinol Unit, Edinburgh EH8 9YL, Midlothian, Scotland.
   Bethlem Royal & Maudsley Hosp, Inst Psychiat, London, England.
   Univ Glasgow, Royal Infirm, Dept Med, Glasgow G12 8QQ, Lanark, Scotland.
   Queen Mary Univ London, Dept Community Psychiat, London, England.
C3 University of London; University College London; University of
   Edinburgh; South London & Maudsley NHS Trust; Bethlem Royal Hospital;
   University of London; King's College London; Royal Infirmary of
   Edinburgh; University of Glasgow; University of London; Queen Mary
   University London
RP UCL, Dept Epidemiol & Publ Hlth, Int Ctr Hlth & Society, 1-19 Torrington Pl, London, England.
EM e.brunner@ucl.ac.uk
RI Andrew, Ruth/C-2727-2008; Seckl, Jonathan/C-3555-2013; Brunner,
   Eric/H-2114-2011; Marmot, Michael/Y-3920-2019; Hemingway,
   Harry/C-1219-2009
OI Marmot, Michael/0000-0002-2431-6419; Andrew, Ruth/0000-0002-6916-2994;
   Brunner, Eric/0000-0002-0595-4474; Hemingway, Harry/0000-0003-2279-0624;
   Kumari, Meena/0000-0001-9716-1035
FU AHRQ HHS [HS06516] Funding Source: Medline; Medical Research Council
   [G8802774, G0100222, G19/35] Funding Source: Medline; NHLBI NIH HHS
   [HL36310] Funding Source: Medline; NIA NIH HHS [AG13196] Funding Source:
   Medline
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NR 31
TC 409
Z9 460
U1 0
U2 27
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0009-7322
EI 1524-4539
J9 CIRCULATION
JI Circulation
PD NOV 19
PY 2002
VL 106
IS 21
BP 2659
EP 2665
DI 10.1161/01.CIR.0000038364.26310.BD
PG 7
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 618LX
UT WOS:000179420500009
PM 12438290
OA Bronze
DA 2025-06-11
ER

PT J
AU Huang, YJ
   Tsai, SY
   Chung, KH
   Chen, PH
   Huang, SH
   Kuo, CJ
AF Huang, Yu-Jui
   Tsai, Shang-Ying
   Chung, Kuo-Hsuan
   Chen, Pao-Huan
   Huang, Shou-Hung
   Kuo, Chian-Jue
TI State-dependent alterations of lipid profiles in patients with bipolar
   disorder
SO INTERNATIONAL JOURNAL OF PSYCHIATRY IN MEDICINE
LA English
DT Article
DE bipolar disorder; mania; depression; cholesterol; triglyceride
ID METABOLIC SYNDROME; MEMBRANE CHOLESTEROL; SERUM-LIPIDS; RECEPTOR;
   INSULIN; LEPTIN; SCHIZOPHRENIA; INFLAMMATION; DEPRESSION; GLUCOSE
AB Objective Serum lipid levels may be associated with the affective severity of bipolar disorder, but data on lipid profiles in Asian patients with bipolar disorder and the lipid alterations in different states of opposite polarities are scant. We investigated the lipid profiles of patients in the acute affective, partial, and full remission state in bipolar mania and depression.
   Methods The physically healthy patients aged between 18 and 45 years with bipolar I disorder, as well as age-matched healthy normal controls were enrolled. We compared the fasting blood levels of glucose, cholesterol, triglyceride, low-density lipoprotein, and high-density lipoprotein of manic or depressed patients in the acute phase and subsequent partial and full remission with those of their normal controls.
   Results A total of 32 bipolar manic patients (12 women and 20 men), 32 bipolar depressed participants (18 women and 14 men), and 64 healthy control participants took part in this study. The mean cholesterol level in acute mania was significantly lower than that in acute depression (p<0.025). The lowest rate of dyslipidemia (hypertriglyceridemia or low high-density lipoprotein cholesterol) was observed in acute bipolar mania.
   Conclusion Circulating lipid profiles may be easily affected by affective states. The acute manic state may be accompanied by state-dependent lower cholesterol and triglyceride levels relative to that in other mood states.
C1 [Huang, Yu-Jui; Tsai, Shang-Ying; Chung, Kuo-Hsuan; Chen, Pao-Huan; Huang, Shou-Hung] Taipei Med Univ Hosp, Dept Psychiat, Taipei, Taiwan.
   [Huang, Yu-Jui; Tsai, Shang-Ying; Chung, Kuo-Hsuan; Chen, Pao-Huan; Huang, Shou-Hung] Taipei Med Univ Hosp, Psychiat Res Ctr, Taipei, Taiwan.
   [Tsai, Shang-Ying; Chung, Kuo-Hsuan; Chen, Pao-Huan; Huang, Shou-Hung; Kuo, Chian-Jue] Taipei Med Univ, Coll Med, Sch Med, Dept Psychiat, Taipei, Taiwan.
   [Kuo, Chian-Jue] Taipei City Hosp, Songde Branch, Taipei City Psychiat Ctr, Taipei, Taiwan.
C3 Taipei Medical University; Taipei Medical University Hospital; Taipei
   Medical University; Taipei Medical University Hospital; Taipei Medical
   University; Taipei City Hospital
RP Tsai, SY (corresponding author), 252 Wu Hsing St, Taipei 110, Taiwan.
EM tmcpsyts@tmu.edu.tw
RI Chen, Pao-Huan/ABG-5963-2020
OI Chung, Kuo-Hsuan/0000-0002-5570-3972; TSAI,
   SHANGYING/0000-0001-5662-0055
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NR 31
TC 24
Z9 26
U1 0
U2 6
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0091-2174
EI 1541-3527
J9 INT J PSYCHIAT MED
JI Int. J. Psychiatr. Med.
PD JUL
PY 2018
VL 53
IS 4
BP 273
EP 281
DI 10.1177/0091217417749786
PG 9
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA GH6FH
UT WOS:000433538600003
PM 29280686
DA 2025-06-11
ER

PT J
AU Sletten, AC
   Davidson, JW
   Yagabasan, B
   Moores, S
   Schwaiger-Haber, M
   Fujiwara, H
   Gale, S
   Jiang, XT
   Sidhu, R
   Gelman, S
   Zhao, S
   Patti, G
   Ory, DS
   Schaffer, JE
AF Sletten, Arthur C.
   Davidson, Jessica W.
   Yagabasan, Busra
   Moores, Samantha
   Schwaiger-Haber, Michaela
   Fujiwara, Hideji
   Gale, Sarah
   Jiang, Xuntian
   Sidhu, Rohini
   Gelman, Susan
   Zhao, Shuang
   Patti, Gary
   Ory, Daniel S.
   Schaffer, Jean E.
TI Loss of SNORA73 reprograms cellular metabolism and protects against
   steatohepatitis
SO NATURE COMMUNICATIONS
LA English
DT Article
ID SMALL NUCLEOLAR RNAS; PRE-RIBOSOMAL-RNA; HEPATIC STEATOSIS;
   MITOCHONDRIAL DYSFUNCTION; OXIDATIVE-STRESS; ACTIVATION; GLUCOSE; MODEL;
   LIVER; MICE
AB Lipid induced stress contributes to metabolic diseases. Here the authors identify small nucleolar RNA 73 (SNORA73) in a screen for genes that protect against lipotoxicity and show that deficiency of SNORA73 reprograms oxidative metabolism and protects against steatohepatitis in mice.
   Dyslipidemia and resulting lipotoxicity are pathologic signatures of metabolic syndrome and type 2 diabetes. Excess lipid causes cell dysfunction and induces cell death through pleiotropic mechanisms that link to oxidative stress. However, pathways that regulate the response to metabolic stress are not well understood. Herein, we show that disruption of the box H/ACA SNORA73 small nucleolar RNAs encoded within the small nucleolar RNA hosting gene 3 (Snhg3) causes resistance to lipid-induced cell death and general oxidative stress in cultured cells. This protection from metabolic stress is associated with broad reprogramming of oxidative metabolism that is dependent on the mammalian target of rapamycin signaling axis. Furthermore, we show that knockdown of SNORA73 in vivo protects against hepatic steatosis and lipid-induced oxidative stress and inflammation. Our findings demonstrate a role for SNORA73 in the regulation of metabolism and lipotoxicity.
C1 [Sletten, Arthur C.; Fujiwara, Hideji; Gale, Sarah; Jiang, Xuntian; Sidhu, Rohini; Zhao, Shuang; Ory, Daniel S.] Washington Univ, Dept Med, St Louis, MO USA.
   [Davidson, Jessica W.; Yagabasan, Busra; Moores, Samantha; Schaffer, Jean E.] Harvard Med Sch, Joslin Diabet Ctr, Boston, MA 02115 USA.
   [Schwaiger-Haber, Michaela; Gelman, Susan; Patti, Gary] Washington Univ, Dept Chem, St Louis, MO USA.
C3 Washington University (WUSTL); Harvard University; Harvard University
   Medical Affiliates; Joslin Diabetes Center, Inc.; Harvard Medical
   School; Washington University (WUSTL)
RP Schaffer, JE (corresponding author), Harvard Med Sch, Joslin Diabet Ctr, Boston, MA 02115 USA.
EM jean.schaffer@joslin.harvard.edu
RI Ory, Daniel/IAP-9009-2023; Sidhu, Rohini/G-3547-2012
OI Yagabasan, Busra/0000-0003-4351-6165; Schwaiger-Haber,
   Michaela/0000-0002-2715-753X
FU NIH [R01 DK108357, R01 DK064989, F30 DK120141, T32 HL007275, T32
   GM07200]; Washington University Diabetes Research Center [P30 DK020579];
   Joslin Diabetes Research Center [P30 DK036836]; National Institute of
   Diabetes and Digestive and Kidney Diseases [F30DK120141, R01DK064989]
   Funding Source: NIH RePORTER
FX This work was supported by the following grants from the NIH: R01
   DK108357 and R01 DK064989 (J.E.S.); F30 DK120141, T32 HL007275, and T32
   GM07200 (A.C.S.); the Washington University Diabetes Research Center P30
   DK020579 and the Joslin Diabetes Research Center P30 DK036836 (Flow
   Cytometry and Molecular Phenotyping & Genotyping Cores). We thank the
   Joslin Bioinformatics and Biostatistics Core for assistance in analysis
   of RNA sequence data and Dr. James Remington for providing a roGFP
   plasmid.
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NR 85
TC 23
Z9 24
U1 3
U2 13
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
EI 2041-1723
J9 NAT COMMUN
JI Nat. Commun.
PD SEP 1
PY 2021
VL 12
IS 1
AR 5214
DI 10.1038/s41467-021-25457-y
PG 17
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA UL1FX
UT WOS:000692406100020
PM 34471131
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Radajewska, A
   Szyller, J
   Niewiadomska, J
   Noszczyk-Nowak, A
   Bil-Lula, I
AF Radajewska, Anna
   Szyller, Jakub
   Niewiadomska, Joanna
   Noszczyk-Nowak, Agnieszka
   Bil-Lula, Iwona
TI Punica granatum L. Polyphenolic Extract as an Antioxidant to
   Prevent Kidney Injury in Metabolic Syndrome Rats
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Article
ID DIABETIC-NEPHROPATHY; LIPID-PEROXIDATION; OXIDATIVE STRESS; MOLECULE-1
   KIM-1; BLOOD-VISCOSITY; POMEGRANATE; OBESITY; DISEASE; ASSOCIATION;
   GLUTATHIONE
AB Introduction. Obesity and metabolic syndrome (MetS) constitute a rapidly increasing health problem and contribute to the development of multiple comorbidities like acute and chronic kidney disease. Insulin resistance, inappropriate lipolysis, and excess of free fatty acids (FFAs) are associated with glomerulus hyperfiltration and atherosclerosis. The important component of MetS, oxidative stress, is also involved in the destabilization of kidney function and the progression of kidney injury. Natural polyphenols have the ability to reduce the harmful effect of reactive oxygen and nitrogen species (ROS/RNS). Extract derived from Punica granatum L. is rich in punicalagin that demonstrates positive effects in MetS and its associated diseases. The aim of the study was to investigate the effect of bioactive substances of pomegranate peel to kidney damage associated with the MetS. Methods. In this study, we compared biomarkers of oxidative stress in kidney tissue of adult male Zucker Diabetic Fatty (ZDF) rats with MetS and healthy controls that were treated with Punica granatum L. extract at a dose of 100 or 200 mg/kg. Additionally, we evaluated the effect of polyphenolic extract on kidney injury markers and remodeling. The concentration of ROS/RNS, oxLDL, glutathione (GSH), kidney injury molecule-1 (KIM-1), neutrophil gelatinase-associated lipocalin (NGAL), metalloproteinase 2 and 9 (MMP-2, MMP-9), and the activity of superoxide dismutase (SOD) and catalase (CAT) were measured. Results. The data showed significant differences in oxidative stress markers between treated and untreated MetS rats. ROS/RNS levels, oxLDL concentration, and SOD activity were lower, whereas CAT activity was higher in rats with MetS receiving polyphenolic extract. After administration of the extract, markers for kidney injury (NGAL, KIM-1) decreased. Conclusion. Our study confirmed the usefulness of pomegranate polyphenols in the treatment of MetS and the prevention of kidney damage. However, further, more detailed research is required to establish the mechanism of polyphenol protection.
C1 [Radajewska, Anna; Szyller, Jakub; Bil-Lula, Iwona] Wroclaw Med Univ, Fac Pharm, Dept Med Lab Diag, Div Clin Chem & Lab Hematol, Borowska 211A, PL-50556 Wroclaw, Poland.
   [Niewiadomska, Joanna; Noszczyk-Nowak, Agnieszka] Univ Environm & Life Sci, Dept Internal Med, Grunwaldzki Sq 47, PL-50366 Wroclaw, Poland.
   [Niewiadomska, Joanna; Noszczyk-Nowak, Agnieszka] Univ Environm & Life Sci, Fac Vet Med, Clin Dis Horses Dogs & Cats, Grunwaldzki Sq 47, PL-50366 Wroclaw, Poland.
C3 Wroclaw Medical University; Wroclaw University of Environmental & Life
   Sciences; Wroclaw University of Environmental & Life Sciences
RP Bil-Lula, I (corresponding author), Wroclaw Med Univ, Fac Pharm, Dept Med Lab Diag, Div Clin Chem & Lab Hematol, Borowska 211A, PL-50556 Wroclaw, Poland.
EM anna.radajewska@student.umw.edu.pl; jakub.szyller@umw.edu.pl;
   joanna.niewiadomska@upwr.edu.pl; agnieszka.noszczyk-nowak@upwr.edu.pl;
   iwona.bil-lula@umw.edu.pl
RI Noszczyk-Nowak, Agnieszka/AAF-8041-2020; Szyller, Jakub/AAZ-1156-2021;
   Bil-Lula, Iwona/ABA-2361-2021; Noszczyk-Nowak, Agnieszka/G-9438-2017
OI Szyller, Jakub/0000-0002-1320-4112; Noszczyk-Nowak,
   Agnieszka/0000-0001-7899-3936; Niewiadomska, Joanna/0000-0001-7102-0779;
   Bil-Lula, Iwona/0000-0002-2769-0166; Radajewska,
   Anna/0000-0003-1639-3155
FU Wroclaw Medical University [SUBK.D010.22.010]
FX AcknowledgmentsThis study was supported by the Wroclaw Medical
   University Grant no. SUBK.D010.22.010.
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NR 84
TC 14
Z9 14
U1 2
U2 17
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PD JAN 5
PY 2023
VL 2023
AR 6144967
DI 10.1155/2023/6144967
PG 14
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA 8C9SG
UT WOS:000917940100006
PM 36644578
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Baughman, P
   Andrew, ME
   Burchfiel, CM
   Fekedulegn, D
   Hartley, TA
   Violanti, JM
   Miller, DB
AF Baughman, Penelope
   Andrew, Michael E.
   Burchfiel, Cecil M.
   Fekedulegn, Desta
   Hartley, Tara A.
   Violanti, John M.
   Miller, Diane B.
TI High-Protein Meal Challenge Reveals the Association Between the Salivary
   Cortisol Response and Metabolic Syndrome in Police Officers
SO AMERICAN JOURNAL OF HUMAN BIOLOGY
LA English
DT Article
ID PITUITARY-ADRENAL AXIS; CARDIOVASCULAR-DISEASE; RISK-FACTORS; ABDOMINAL
   OBESITY; WORK STRESS; POSTTRAUMATIC-STRESS; MEN; NEUROENDOCRINE;
   ATHEROSCLEROSIS; ABNORMALITIES
AB Objectives: Policing is considered a high-stress occupation and officers have elevated cardiovascular morbidity and mortality. To investigate a potential connection, we evaluated the association between salivary cortisol response to a high-protein meal challenge and the metabolic syndrome (MetSyn), a subclinical disorder associated with increased cardiovascular risk.
   Methods: Cross-sectional data were from the Buffalo Cardio-Metabolic Occupational Police Stress (BCOPS) Study (2004-2009). MetSyn was defined as having >= 3 components: abdominal obesity, hypertension, elevated triglycerides, reduced high-density lipoprotein cholesterol, and glucose intolerance. Officers provided five saliva samples for cortisol analysis, one before challenge (high-protein shake) and four at 15-min intervals thereafter, where the usual response is increase. Regression models were used to examine trends in mean number of MetSyn components across quartiles of area under the curve (AUC) salivary cortisol. Patterns of mean cortisol response were assessed by MetSyn status using repeated-measures analysis of covariance.
   Results: Prevalence of MetSyn was 25.7% among 373 officers (74.0% male). The mean count of MetSyn components decreased (1.89, 1.75, 1.55, 1.37; P < 0.01) across increasing quartiles of AUC salivary cortisol. Mean salivary cortisol decreased from baseline (5.55, 4.58, 4.47, 4.79, 4.75 nmol/l) in officers with MetSyn and increased (5.08, 5.82, 5.92, 5.82, 5.60 nmol/l) in their counterparts. The test for interaction between MetSyn status and time of saliva collection was statistically significant (P < 0.001).
   Conclusions: Reduced cortisol response to a high-protein meal challenge may be associated with MetSyn. Future longitudinal studies could provide useful evidence for planning intervention studies on cardiovascular risk among police officers. (C) 2015 Wiley Periodicals, Inc.
C1 [Baughman, Penelope; Andrew, Michael E.; Burchfiel, Cecil M.; Fekedulegn, Desta; Hartley, Tara A.] NIOSH, Biostat & Epidemiol Branch, Hlth Effects Lab Div, Ctr Dis Control & Prevent, Morgantown, WV USA.
   [Baughman, Penelope] Ctr Dis Control & Prevent, Epidem Intelligence Serv Program, Atlanta, GA USA.
   [Violanti, John M.] SUNY Buffalo, Sch Publ Hlth & Hlth Profess, Dept Epidemiol & Environm Hlth, Buffalo, NY 14260 USA.
   [Miller, Diane B.] NIOSH, Toxicol & Mol Biol Branch, Hlth Effects Lab Div, Ctr Dis Control & Prevent, Morgantown, WV USA.
C3 Centers for Disease Control & Prevention - USA; National Institute for
   Occupational Safety & Health (NIOSH); Centers for Disease Control &
   Prevention - USA; State University of New York (SUNY) System; University
   at Buffalo, SUNY; Centers for Disease Control & Prevention - USA;
   National Institute for Occupational Safety & Health (NIOSH)
RP Baughman, P (corresponding author), NIOSH, 1095 Willowdale Rd,MS 4050, Morgantown, WV 26505 USA.
EM pbaughman@cdc.gov
OI Baughman, Penelope/0000-0002-5384-3621
FU National Institute for Occupational Safety and Health [200-2003-01580]
FX Contract grant sponsor: National Institute for Occupational Safety and
   Health; Contract grant number: 200-2003-01580.
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NR 38
TC 9
Z9 10
U1 0
U2 11
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1042-0533
EI 1520-6300
J9 AM J HUM BIOL
JI Am. J. Hum. Biol.
PD JAN-FEB
PY 2016
VL 28
IS 1
BP 138
EP 144
DI 10.1002/ajhb.22748
PG 7
WC Anthropology; Biology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Anthropology; Life Sciences & Biomedicine - Other Topics
GA DB4RO
UT WOS:000368501000015
PM 26088798
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Powell, CR
   Kim, A
   Roth, J
   Byrd, JP
   Mohammad, K
   Alloosh, M
   Vittal, R
   Sturek, M
AF Powell, Charles R.
   Kim, Albert
   Roth, Joshua
   Byrd, James P.
   Mohammad, Khalid
   Alloosh, Mouhamad
   Vittal, Ragini
   Sturek, Michael
TI Ossabaw Pig Demonstrates Detrusor Fibrosis and Detrusor Underactivity
   Associated with Oxidative Stress in Metabolic Syndrome
SO COMPARATIVE MEDICINE
LA English
DT Article
ID BLADDER DYSFUNCTION; DIABETES-MELLITUS; WOMEN; MODEL; DIET
AB Metabolic Syndrome (MetS) has detrimental effects on the bladder, including detrusor underactivity. The progression and mechanism of disease are poorly understood. A swine model for diabetic bladder dysfunction (DBD) was established because of the pig's human-sized bladder and its ability to develop MetS by dietary modification alone. The hypothesis of this study is that this swine model will demonstrate oxidative stress associated with MetS, which contributes to both bladder fibrosis and detrusor underactivity (DU). Ossabaw pigs underwent dietary modification consisting of a hypercaloric, atherogenic diet for 10 mo to induce MetS, and were compared with a group of control (lean) pigs. Urodynamic studies were performed in both groups to confirm DU. Thiobarbituric acid reactive substances (TBARS) detected in the urine were used to measure oxidative stress activity in the urinary tract, and urinary IL17a was used to detect profibrotic activity. MetS was confirmed by assessing body weight, blood pressure, glucose tolerance, total cholesterol, and triglycerides. The MetS group exhibited an increase in the relative levels of urinary TBARS and IL17a. Bladder pressures at capacity were lower in the MetS group, suggesting DU. Histologic analysis of a cohort of control (lean) and MetS pigs revealed that as compared with the control pigs, the MetS pigs had significantly more collagen in the muscularis layer, but not in the submucosa or mucosa layer. In conclusion, the Ossabaw pig model for diet-induced MetS is associated with oxidative stress and profibrotic activity in the bladder, which results in DU. This has previously been shown in mice and rats, but never in pigs. This novel model will better represent human MetS and DBD because the mechanism and size of the pig bladder more closely resemble that of a human, resulting in a more valid model and facilitating further study into the signaling mechanisms responsible for this impairment.
C1 [Powell, Charles R.; Roth, Joshua] Indiana Univ, Sch Med, Dept Urol, Indianapolis, IN 46202 USA.
   [Kim, Albert] Temple Univ, Coll Engn, Philadelphia, PA USA.
   [Byrd, James P.; Alloosh, Mouhamad; Sturek, Michael] Indiana Univ, Sch Med, Dept Anat Cell Biol & Physiol, Indianapolis, IN USA.
   [Mohammad, Khalid] Indiana Univ, Sch Med, Dept Med, Endocrinol Div, Indianapolis, IN USA.
   [Sturek, Michael] Purdue Univ, Purdue Weldon Sch Biomed Engn, W Lafayette, IN 47907 USA.
   [Vittal, Ragini] Univ Michigan, Dept Pulm & Crit Care Med, Ann Arbor, MI USA.
C3 Indiana University System; Indiana University Indianapolis; Pennsylvania
   Commonwealth System of Higher Education (PCSHE); Temple University;
   Indiana University System; Indiana University Indianapolis; Indiana
   University System; Indiana University Indianapolis; Purdue University
   System; Purdue University; University of Michigan System; University of
   Michigan
RP Powell, CR (corresponding author), Indiana Univ, Sch Med, Dept Urol, Indianapolis, IN 46202 USA.
EM crpowell@iupui.edu
RI Mohammad, Khalid/AFE-4205-2022; Sturek, Michael/CAH-2948-2022; VITTAL,
   RAGINI/AAE-9052-2020; Kim, Albert/Q-9686-2017
OI Kim, Albert/0000-0003-1539-1246; Sturek, Michael/0000-0002-2920-7406; ,
   Khalid/0009-0006-9708-2111
FU Project Development Team within the ICTSI NIH/NCRR Grant [RR025761];
   NIDDK DiaComp Pilot & Feasibility project [DK076169]; NIH [HL062552, UL1
   RR025761, P30 DK097512]; NIH NHLBI [R01HL109288]
FX All authors have read the journal's authorship agreement and policy on
   disclosure of potential conflicts of interest. This project was
   supported by a Project Development Team within the ICTSI NIH/NCRR Grant
   Number RR025761 (Powell, PI) and NIDDK DiaComp Pilot & Feasibility
   project, sub-award DK076169 (Powell, PI) and NIH grant HL062552 (Sturek,
   PI), NIH UL1 RR025761 (Sturek, CO-I), NIH P30 DK097512 (Sturek Co-I),
   NIH NHLBI R01HL109288 (Vittal, PI).
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NR 32
TC 6
Z9 6
U1 0
U2 0
PU AMER ASSOC LABORATORY ANIMAL SCIENCE
PI MEMPHIS
PA 9190 CRESTWYN HILLS DR, MEMPHIS, TN 38125 USA
SN 1532-0820
J9 COMPARATIVE MED
JI Comparative Med.
PD OCT
PY 2020
VL 70
IS 5
BP 329
EP 334
DI 10.30802/AALAS-CM-20-000004
PG 6
WC Veterinary Sciences; Zoology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences; Zoology
GA PX0TD
UT WOS:000611076900003
PM 32972487
OA Green Published
DA 2025-06-11
ER

PT J
AU Tarantino, G
   Caputi, A
AF Tarantino, Giovanni
   Caputi, Armando
TI JNKs, insulin resistance and inflammation: A possible link between NAFLD
   and coronary artery disease
SO WORLD JOURNAL OF GASTROENTEROLOGY
LA English
DT Article
DE Non-alcoholic fatty liver disease; c-Jun amino-terminal kinase;
   Cardiovascular disease
ID FATTY LIVER-DISEASE; N-TERMINAL KINASE; ENDOPLASMIC-RETICULUM STRESS;
   JUN NH2-TERMINAL KINASE; NONALCOHOLIC STEATOHEPATITIS; CARDIOVASCULAR
   RISK; SIGNALING PATHWAYS; METABOLIC SYNDROME; OXIDATIVE STRESS;
   LIPID-METABOLISM
AB The incidence of obesity has dramatically increased in recent years. Consequently, obesity and associated disorders such as nonalcoholic fatty liver disease constitute a serious problem. Therefore, the contribution of adipose tissue to metabolic homeostasis has become a focus of interest. In this review, we discuss the latest discoveries that support the role of lipids in nonalcoholic fatty liver disease. We describe the common mechanisms (c-Jun amino-terminal kinases, endoplasmic reticulum stress, unfolded protein response, ceramide, low-grade chronic inflammation) by which lipids and their derivatives impair insulin responsiveness and contribute to inflammatory liver and promote plaque instability in the arterial wall. Presenting the molecular mechanism of lipid activation of pro-inflammatory pathways, we attempt to find a link between nonalcoholic fatty liver disease, metabolic syndrome and cardiovascular diseases. Describing the common mechanisms by which lipid derivatives, through modulation of macrophage function, promote plaque instability in the arterial wall, impair insulin responsiveness and contribute to inflammatory liver and discussing the molecular mechanism of lipid activation of pro-inflammatory pathways, the key roles played by the proliferator-activated receptor and liver X receptor alpha, nuclear receptors-lipid sensors that link lipid metabolism and inflammation, should be emphasized. Further studies are warranted of anti-inflammatory drugs such as aspirin, anti-interleukin-6 receptors, immune-modulators (calcineurin inhibitors), substances enhancing the expression of heat shock proteins (which protect cells from endoplasmic reticulum stress-induced apoptosis), and anti- c-Jun amino-terminal kinases in well-designed trials to try to minimize the high impact of these illnesses, and the different expressions of the diseases, on the whole population. (C) 2011 Baishideng. All rights reserved.
C1 [Tarantino, Giovanni] Univ Naples Federico II, Med Sch Naples, Dept Clin & Expt Med, I-80131 Naples, Italy.
   [Caputi, Armando] Univ Naples Federico II, Med Sch Naples, Dept Clin Med Cardiovasc & Immunol Sci, I-80131 Naples, Italy.
C3 University of Naples Federico II; University of Naples Federico II
RP Tarantino, G (corresponding author), Univ Naples Federico II, Med Sch Naples, Dept Clin & Expt Med, Via Sergio Pansini 5, I-80131 Naples, Italy.
EM tarantin@unina.it
RI Tarantino, Giovanni/AAW-2007-2021
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NR 56
TC 116
Z9 127
U1 0
U2 15
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 8226 REGENCY DR, PLEASANTON, CA 94588 USA
SN 1007-9327
EI 2219-2840
J9 WORLD J GASTROENTERO
JI World J. Gastroenterol.
PD SEP 7
PY 2011
VL 17
IS 33
BP 3785
EP 3794
DI 10.3748/wjg.v17.i33.3785
PG 10
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 834OM
UT WOS:000295971500003
PM 21987620
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Selvaraju, V
   Joshi, M
   Suresh, S
   Sanchez, JA
   Maulik, N
   Maulik, G
AF Selvaraju, Vaithinathan
   Joshi, Mandip
   Suresh, Sumanth
   Sanchez, Juan A.
   Maulik, Nilanjana
   Maulik, Gautam
TI Diabetes, oxidative stress, molecular mechanism, and cardiovascular
   disease - an overview
SO TOXICOLOGY MECHANISMS AND METHODS
LA English
DT Review
DE Oxidative stress; diabetes; hyperglycemia; cardiovascular disease;
   reactive oxygen species
ID TUMOR-NECROSIS-FACTOR; ENDOTHELIAL DYSFUNCTION; LIPID-PEROXIDATION;
   METABOLIC SYNDROME; NAD(P)H OXIDASE; FREE-RADICALS; KAPPA-B; RATS;
   ANTIOXIDANT; CARDIOMYOPATHY
AB In recent years, diabetes and its associated complications have come to represent a major public health concern. It is a complex disease characterized by multiple metabolic derangements and is known to impair cardiac function by disrupting the balance between pro-oxidants and antioxidants at the cellular level. The subsequent generation of reactive oxygen species (ROS) and accompanying oxidative stress are hallmarks of the molecular mechanisms responsible for cardiovascular disease. Among several oxidative stress-mediated mechanisms that have been proposed, ROS-mediated oxidative stress has received the most attention. ROS have been shown to interact with proteins, lipids, and DNA, causing damage to the cellular macromolecules and subsequently, deterioration of cellular function. Induction of thioredoxin-1 (Trx1) gene expression has been demonstrated to protect the diabetic myocardium from dysfunction by reducing oxidative stress and enhancing the expression of heme oxygenase-1 (HO-1) and vascular endothelial growth factor (VEGF). The failure of antioxidants to consistently demonstrate clinical benefit necessitates further investigation of the role of oxidative stress in diabetes-mediated cardiovascular disease.
C1 [Maulik, Gautam] Harvard Univ, Sch Med, Dept Radiol, Boston, MA 02115 USA.
   [Selvaraju, Vaithinathan; Joshi, Mandip; Suresh, Sumanth; Sanchez, Juan A.; Maulik, Nilanjana] Univ Connecticut, Ctr Hlth, Dept Surg, Mol Cardiol & Angiogenesis Lab, Farmington, CT USA.
C3 Harvard University; Harvard Medical School; University of Connecticut
RP Maulik, G (corresponding author), Harvard Univ, Sch Med, Dept Radiol, 200 Longwood Ave, Boston, MA 02115 USA.
RI Vaithinathan, Selvaraju/D-4277-2013; Sanchez, Juan/AAQ-1488-2020;
   Sanchez, Juan/I-1936-2016
OI Sanchez, Juan/0000-0002-6789-3208
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NR 71
TC 81
Z9 96
U1 0
U2 43
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1537-6516
EI 1537-6524
J9 TOXICOL MECH METHOD
JI Toxicol. Mech. Methods
PD JUN
PY 2012
VL 22
IS 5
BP 330
EP 335
DI 10.3109/15376516.2012.666648
PG 6
WC Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Toxicology
GA 939SQ
UT WOS:000303835200003
PM 22394340
DA 2025-06-11
ER

PT J
AU Pomngen, I
   Sirisatayawong, P
   Kumsaiyai, W
   Kaunnil, A
   Srikhamjak, T
AF Pomngen, Ilada
   Sirisatayawong, Pornpen
   Kumsaiyai, Warunee
   Kaunnil, Anuchart
   Srikhamjak, Tiam
TI Relationships between sensory processing patterns and metabolic risk
   factors among community dwelling people with metabolic syndrome: A
   cross-sectional and correlational research design
SO PLOS ONE
LA English
DT Article
ID PHYSICAL-ACTIVITY; SEDENTARY BEHAVIOR; BLOOD-PRESSURE; SENSITIVITY;
   STRESS; TIME; ASSOCIATIONS; PERCEPTION; HEALTH; LIFE
AB Background Metabolic Syndrome (MetS) increases the risk of other serious health problems, particularly cardiovascular diseases and stroke. Sensory processing patterns (SPPs) are internal factors shaping behaviors and emotions, both healthy and unhealthy. There is a lack of studies directly examining the relationship between the SPPs and metabolic risk factors. Method This study aimed to investigate SPPs and their association with metabolic risk factors in individuals with metabolic syndrome (MetS). One hundred and seventeen individuals with MetS completed questionnaires on demographic characteristics and the Thai Sensory Patterns Assessment-adult version. Data on metabolic risk factors, including fasting blood glucose, blood pressure, and waist circumference, were collected. Results The findings revealed high arousal levels in proprioceptive and auditory senses among the participants. The fasting blood glucose was significantly correlated with a preference in the tactile sense (r = -0.150, P<0.05), while waist circumference was associated with arousal level in the auditory and smell-taste senses (r = 0.140, -0.160, P<0.05). Moreover, the GLMM revealed that fasting blood glucose was associated with preferences in tactile, vestibular, and proprioceptive senses (r = -0.481, 0.726, -0.386, P<0.05). Furthermore, diastolic blood pressure was associated with preferences in vestibular sense (r = 0.099; P<0.05). Conclusion The SPPs might be related to metabolic risk factors, so it is important to recognize how individual SPPs relate to metabolic risk factors. However, further studies using a larger sample may be needed to deeply explore the mechanisms underlying these associations.
C1 [Pomngen, Ilada; Sirisatayawong, Pornpen; Kaunnil, Anuchart; Srikhamjak, Tiam] Chiang Mai Univ, Fac Associated Med Sci, Dept Occupat Therapy, Chiang Mai, Thailand.
   [Kumsaiyai, Warunee] Chiang Mai Univ, Fac Associated Med Sci, Dept Med Technol, Chiang Mai, Thailand.
C3 Chiang Mai University; Chiang Mai University
RP Srikhamjak, T (corresponding author), Chiang Mai Univ, Fac Associated Med Sci, Dept Occupat Therapy, Chiang Mai, Thailand.
EM tiamsrikhamjak@gmail.com
RI KAUNNIL, ANUCHART/B-1818-2016
OI KAUNNIL, ANUCHART/0000-0002-8178-6513; pomngen,
   ilada/0000-0003-0280-6297
FU Faculty of Associated Medical Sciences, Chiang Mai University;
   Department of Occupational Therapy, Faculty of Associated Medical
   Sciences, Chiang Mai University
FX This research was supported by the Department of Occupational Therapy,
   Faculty of Associated Medical Sciences, Chiang Mai University.
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   Zickgraf HF, 2016, FOOD QUAL PREFER, V54, P39, DOI 10.1016/j.foodqual.2016.06.012
NR 60
TC 0
Z9 0
U1 1
U2 1
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD SEP 6
PY 2024
VL 19
IS 9
AR e0308421
DI 10.1371/journal.pone.0308421
PG 19
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA H9O4X
UT WOS:001326653200136
PM 39241047
OA gold
DA 2025-06-11
ER

PT J
AU Wang, AQ
   Liu, M
   Shang, WT
   Liu, JG
   Dai, Z
   Strappe, P
   Zhou, ZK
AF Wang, Anqi
   Liu, Min
   Shang, Wenting
   Liu, Jinguang
   Dai, Zhen
   Strappe, Padraig
   Zhou, Zhongkai
TI Attenuation of metabolic syndrome in the ob/ob mouse model by resistant
   starch intervention is dose dependent
SO FOOD & FUNCTION
LA English
DT Article
ID MECHANISMS LINKING OBESITY; DIET-INDUCED OBESITY; CHAIN FATTY-ACIDS;
   INSULIN-RESISTANCE; WEIGHT; MICE; OVEREXPRESSION; ASSOCIATIONS; STRESS;
   RISK
AB The current study applied an ob/ob mouse model of obesity for investigating the impact of different RS doses in a high-fat (HF) diet on the attenuation of metabolic syndrome. Although a significant reduction of body weight was not achieved, RS intervention significantly decreased liver weight with suppressed lipid accumulation in the liver tissue and reduced adipocyte size in the fat tissue. All levels of RS intervention were associated with significantly enriched pathways for PPAR, NAFLD and cGMP-PKG signaling. In contrast, either a medium or a higher RS intake (MRS and HRS, respectively) led the AMPK signaling pathway to be significantly enriched but not a diet with lower RS intake. More importantly, sphingolipid biosynthesis activity was noted with MRS and HRS intervention, which is highly associated with the improvement in insulin resistance, and the pathway of type II diabetes mellitus was correspondingly significantly enriched in the HRS group, demonstrating a dose-dependent manner. Similarly, there was no significant difference in the ratio of Bacteroidetes and Firmicutes between high-fat diet and RS groups until RS reached a certain level (i.e. in the HRS group). Furthermore, increased profiles of both Prevotellaceae and Coriobacteriaceae in the HF group were noted for the first time with a revised function from RS intervention, which is consistent with the content of lipopolysaccharides in their corresponding serum. Gut microbiota functional analysis showed that primary and secondary bile acid biosynthesis was also noted to be enriched following the RS intervention, benefiting cholesterol homeostasis. This study further highlights the association of RS consumption with the attenuation of metabolic syndrome in an obesity model, and its functionality is characterized by dose-dependence.
C1 [Wang, Anqi; Liu, Min; Shang, Wenting; Liu, Jinguang; Dai, Zhen; Zhou, Zhongkai] Tianjin Univ Sci & Technol, Coll Food Engn & Biotechnol, Tianjin 300457, Peoples R China.
   [Strappe, Padraig] Cent Queensland Univ, Sch Med & Appl Sci, Rockhampton, Qld 4700, Australia.
   [Zhou, Zhongkai] Charles Sturt Univ, ARC Funct Grains Ctr, Wagga Wagga, NSW 2678, Australia.
C3 Tianjin University Science & Technology; Central Queensland University;
   Charles Sturt University
RP Zhou, ZK (corresponding author), Tianjin Univ Sci & Technol, Coll Food Engn & Biotechnol, Tianjin 300457, Peoples R China.; Zhou, ZK (corresponding author), Charles Sturt Univ, ARC Funct Grains Ctr, Wagga Wagga, NSW 2678, Australia.
EM zzhou@csu.edu.au
RI Zhou, Zhongkai/AAC-1412-2019; Dai, Zhen/AAS-4858-2020; Shang,
   Wenting/E-8475-2018; min, liu/AAX-1641-2021
OI Zhou, Zhongkai/0000-0003-1918-413X; Wang, Anqi/0000-0002-7967-570X
FU National Key Research and Development Program [2016YFD0400401-2];
   National Nature Science Foundation of China [U1501214]
FX This work was financially supported by the National Key Research and
   Development Program (2016YFD0400401-2) and the National Nature Science
   Foundation of China (No. U1501214).
CR [Anonymous], J PEDIAT GASTROENTER
   [Anonymous], COCHRANE DATABASE SY
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NR 51
TC 22
Z9 23
U1 0
U2 31
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PD DEC 1
PY 2019
VL 10
IS 12
BP 7940
EP 7951
DI 10.1039/c9fo01771b
PG 12
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA KD1PE
UT WOS:000507643700028
PM 31777896
DA 2025-06-11
ER

PT J
AU Talari, HR
   Rafiee, M
   Farrokhian, A
   Raygan, F
   Bahmani, F
   Mofrad, MD
   Hamidian, Y
   Tamtaji, OR
   Karamali, F
   Asemi, Z
AF Talari, Hamid Reza
   Rafiee, Motahereh
   Farrokhian, Alireza
   Raygan, Fariba
   Bahmani, Fereshteh
   Mofrad, Manijeh Darooghegi
   Hamidian, Yaser
   Tamtaji, Omid Reza
   Karamali, Fatemeh
   Asemi, Zatollah
TI The Effects of Folate Supplementation on Carotid Intima-Media Thickness
   and Metabolic Status in Patients with Metabolic Syndrome
SO ANNALS OF NUTRITION AND METABOLISM
LA English
DT Article
DE Folate; Supplementation; Carotid intima-media thickness; Metabolic
   status; Metabolic syndrome
ID FOLIC-ACID SUPPLEMENTATION; POLYCYSTIC-OVARY-SYNDROME;
   CORONARY-HEART-DISEASE; B-GROUP-VITAMINS; INSULIN-RESISTANCE; OXIDATIVE
   STRESS; CARDIOVASCULAR-DISEASE; ENDOTHELIAL FUNCTION; PLASMA
   HOMOCYSTEINE; ARTERIAL STIFFNESS
AB Background: This study was carried out to evaluate the effects of folate supplementation on carotid intima-media thickness (CIMT) and metabolic status among patients with metabolic syndrome (MetS). Methods: This randomized, double-blind, placebo-controlled trial was conducted among 60 patients with type 2 diabetes mellitus and coronary heart disease. They were all overweight in the age range 40-85 years. Participants were randomly divided into 2 groups: group A (n = 30) received 5 mg folate supplements and group B (n = 30) received placebo for 12 weeks. Results: Folate supplementation resulted in a significant reduction in maximum levels of left CIMT (-0.05 +/- 0.13 vs. +0.02 +/- 0.11 mm, p = 0.01) compared with the placebo. Changes in fasting plasma glucose (-2.2 +/- 37.5 vs. +30.2 +/- 65.8 mg/dl, p = 0.02), serum insulin concentration (-2.0 +/- 10.7 vs. +3.0 +/- 7.6 p = 0.04) and homeostasis of assessment-estimated insulin resistance (-0.6 +/- 2.3 vs. +0.9 +/- 2.3, p = 0.01) in supplemented patients were significantly different from those of patients in the placebo group. Changes in serum triglycerides (p = 0.04), high-density lipoprotein-cholesterol (p = 0.001), high sensitivity C-reactive protein (p = 0.01) and plasma nitric oxide concentrations (p < 0.001) were significantly different between the supplemented patients and placebo group. Conclusions: Overall, 5 mg/day folate supplementation for 12 weeks among patients with MetS had beneficial effects on CIMT and the metabolic status. (C) 2016 S. Karger AG, Basel.
C1 [Talari, Hamid Reza; Rafiee, Motahereh; Hamidian, Yaser] Kashan Univ Med Sci, Dept Radiol, Kashan, Iran.
   [Farrokhian, Alireza; Raygan, Fariba] Kashan Univ Med Sci, Sch Med, Dept Cardiol, Kashan, Iran.
   [Bahmani, Fereshteh; Mofrad, Manijeh Darooghegi; Asemi, Zatollah] Kashan Univ Med Sci, Res Ctr Biochem & Nutr Metab Dis, Kashan, Iran.
   [Tamtaji, Omid Reza] Kashan Univ Med Sci, Physiol Res Ctr, Kashan, Iran.
   [Karamali, Fatemeh] Iran Univ Med Sci, Rajaie Cardiovasc Med & Res Ctr, Tehran, Iran.
C3 Iran University of Medical Sciences
RP Asemi, Z (corresponding author), Kashan Univ Med Sci, Res Ctr Biochem & Nutr Metab Dis, Kashan, Iran.
EM asemi_r@yahoo.com
RI Raygan, Fariba/GYU-8723-2022; asemi, zatollah/J-2677-2018; tamtaji,
   M/KWU-3655-2024; Farrokhian, Alireza/G-8864-2017; Asemi,
   Zatollah/G-7393-2017; Talari, Hamidreza/H-7838-2017; Bahmani,
   Fereshteh/G-7641-2017
OI Farrokhian, Alireza/0000-0002-7814-5539; Asemi,
   Zatollah/0000-0001-5265-4792; Talari, Hamidreza/0000-0001-6736-8449;
   Bahmani, Fereshteh/0000-0003-0683-3153; Tamtaji, Omid
   Reza/0000-0003-2492-3996; Raygan, Fariba/0000-0003-3789-5584
FU KUMS
FX This study was supported by a grant from the Vice-chancellor for
   Research, KUMS, and Iran.
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NR 44
TC 27
Z9 27
U1 0
U2 6
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0250-6807
EI 1421-9697
J9 ANN NUTR METAB
JI Ann. Nutr. Metab.
PY 2016
VL 69
IS 1
BP 41
EP 50
DI 10.1159/000448295
PG 10
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA DV8WB
UT WOS:000383216300006
PM 27450552
DA 2025-06-11
ER

PT J
AU Gomaraschi, M
   Ossoli, A
   Adorni, MP
   Damonte, E
   Niesor, E
   Veglia, F
   Franceschini, G
   Benghozi, R
   Calabresi, L
AF Gomaraschi, Monica
   Ossoli, Alice
   Adorni, Maria Pia
   Damonte, Elisabetta
   Niesor, Eric
   Veglia, Fabrizio
   Franceschini, Guido
   Benghozi, Renee
   Calabresi, Laura
TI Fenofibrate and extended-release niacin improve the endothelial
   protective effects of HDL in patients with metabolic syndrome
SO VASCULAR PHARMACOLOGY
LA English
DT Article
DE High density lipoprotein; Niacin; Fenofibrate; Endothelial cells; Nitric
   oxide
ID HIGH-DENSITY-LIPOPROTEIN; TYPE-2 DIABETES-MELLITUS; SCAVENGER
   RECEPTOR-BI; NITRIC-OXIDE SYNTHASE; CORONARY-HEART-DISEASE; COMBINED
   HYPERLIPIDEMIA; INFLAMMATORY MARKERS; VASCULAR REACTIVITY; CHOLESTEROL
   LEVELS; OXIDATIVE STRESS
AB Background: Fibrates and niacin are at present the most effective therapies to increase plasma levels of high density lipoprotein-cholesterol (HDL-C); to date, limited data are available on their effects on HDL protective functions.
   Methods and results: Within a multicenter, randomized, open-label, cross-over study, 37 patients with metabolic syndrome received 6 weeks' treatment with fenofibrate or extended-release niacin (ER niacin), with a 4 weeks' wash-out period. HDL ability to preserve endothelial cell homeostasis was assessed by incubating cultured endothelial cells with HDL isolated from patients at baseline and after each treatment. HDL isolated from patients at baseline were as effective as control HDL in inhibiting vascular cell adhesion molecule-1 (VCAM-1) expression, but less efficient in promoting endothelial cell nitric oxide (NO) release. Both fenofibrate and ER niacin increased HDL ability to inhibit TNF alpha-induced VCAM-1 expression (+7% and +11%, respectively). Fenofibrate and ER niacin also improved the impaired HDL ability to induce the expression of endothelial nitric oxide synthase and NO production (+10% and +8%, respectively). Interestingly. HDL isolated after treatment showed an ability to promote endothelial NO release similar to HDL isolated from controls. No differences were observed between the two drugs. With both drugs, HDL function was improved irrespective of baseline HDL-C levels.
   Conclusion: Treatment with fenofibrate or ER niacin in patients with metabolic syndrome not only increased HDL-C levels but also improved the endothelial protective effects of HDL. (C) 2015 Elsevier Inc. All rights reserved.
C1 [Gomaraschi, Monica; Ossoli, Alice; Franceschini, Guido; Calabresi, Laura] Univ Milan, Dipartimento Sci Farmacol & Biomol, Ctr E Grossi Paoletti, I-20133 Milan, Italy.
   [Adorni, Maria Pia] Univ Parma, Dept Pharm, I-43100 Parma, Italy.
   [Damonte, Elisabetta; Niesor, Eric; Benghozi, Renee] F Hoffmann La Roche Ltd, Basel, Switzerland.
   [Veglia, Fabrizio] IRCCS Cardiol Monzino, Milan, Italy.
C3 University of Milan; University of Parma; Roche Holding
RP Calabresi, L (corresponding author), Univ Milan, Dept Pharmacol & Biomol Sci, Via Balzaretti 9, I-20133 Milan, Italy.
EM laura.calabresi@unimi.it
RI Adorni, Maria/C-9887-2012; Veglia, Fabrizio/K-1958-2016; Gomaraschi,
   Monica/A-3601-2014; Ossoli, Alice/K-5917-2016
OI Calabresi, Laura/0000-0001-5042-9532; Veglia,
   Fabrizio/0000-0002-9378-8874; Gomaraschi, Monica/0000-0003-3082-2120;
   Ossoli, Alice/0000-0002-9902-252X; FRANCESCHINI,
   GUIDO/0000-0003-2687-1771
FU F. Hoffmann-La Roche Ltd, Basel, Switzerland [BP20843]
FX The study was supported by F. Hoffmann-La Roche Ltd, Basel, Switzerland
   (BP20843).
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NR 52
TC 11
Z9 11
U1 1
U2 2
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1537-1891
EI 1879-3649
J9 VASC PHARMACOL
JI Vasc. Pharmacol.
PD NOV
PY 2015
VL 74
BP 80
EP 86
DI 10.1016/j.vph.2015.06.014
PG 7
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA CY1DE
UT WOS:000366146100008
PM 26133666
DA 2025-06-11
ER

PT J
AU Yao, JM
   Zhao, Y
   Zhang, JW
   Hong, YN
   Lu, HL
   Wu, JP
AF Yao, Jinmei
   Zhao, Ying
   Zhang, Juanwen
   Hong, Yani
   Lu, Huanle
   Wu, Jianping
TI Serum amylase levels are decreased in Chinese non-alcoholic fatty liver
   disease patients
SO LIPIDS IN HEALTH AND DISEASE
LA English
DT Article
DE NAFLD; Amylase; Metabolic syndrome; Fibrosis
ID ENDOPLASMIC-RETICULUM STRESS; HEPATIC INSULIN-RESISTANCE; METABOLIC
   SYNDROME; RISK-FACTORS; DIABETES-MELLITUS; NATURAL-HISTORY;
   STEATOHEPATITIS; ASSOCIATION; POPULATION; STEATOSIS
AB Background: Low serum amylase levels have been reported in patients with metabolic syndrome (MS), diabetes, and asymptomatic non-alcoholic fatty liver disease (NAFLD). However, no study has yet indicated the serum amylase levels in NAFLD with MS. The aim of the present study was to evaluate serum amylase levels in NAFLD patients with and without MS, and to explore a possible association between serum amylase levels with the components of MS and the degree of hepatic fibrosis in NAFLD patients.
   Methods: Our study included 713 NAFLD participants (180 females and 533 males) and 304 healthy control participants (110 females and 194 males). The diagnosis of NAFLD was based on ultrasonography, and advanced fibrosis was assessed by the FIB-4 index.
   Results: Serum amylase levels were significantly lower in NAFLD patients with MS compared with NAFLD patients without MS and healthy controls (42, 45, and 53 IU/L, respectively). The serum amylase levels of patients with elevated glucose, elevated triglycerides, and low high density lipoprotein cholesterol patients were significantly lower than in case of normal parameters (both p < 0.05). Multivariate logistic regression analysis showed that a relative serum amylase level increase was an independent factor predicting advanced fibrosis (FIB-4 = 1.3) in NAFLD participants (OR: 1.840, 95% CI: 1.117-3.030, p = 0.017).
   Conclusions: Compared with NAFLD patients without MS and healthy controls, serum amylase levels were significantly lower in NAFLD patients with MS. Moreover, a relative serum amylase increase may be an independent factor of more advanced hepatic fibrosis.
C1 [Yao, Jinmei; Zhao, Ying; Zhang, Juanwen; Hong, Yani; Lu, Huanle; Wu, Jianping] Zhejiang Univ, Coll Med, Affiliated Hosp 1, Dept Lab Med, Hangzhou 310003, Zhejiang, Peoples R China.
C3 Zhejiang University
RP Zhang, JW (corresponding author), Zhejiang Univ, Coll Med, Affiliated Hosp 1, Dept Lab Med, 79 QingChun Rd, Hangzhou 310003, Zhejiang, Peoples R China.
EM tym2011@yeah.net
RI Wu, Jianping/H-9150-2012
FU Department of Education Foundation of Zhejiang Province, China
   [Y201330146]; Science Foundation of the Health Bureau of Zhejiang
   Province [2013KYB116]; National Natural Science Foundation of China
   [81370008]
FX This work was financially supported by grants from the Department of
   Education Foundation of Zhejiang Province, China (No. Y201330146), the
   Science Foundation of the Health Bureau of Zhejiang Province (No.
   2013KYB116), and the National Natural Science Foundation of China (No.
   81370008).
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NR 53
TC 12
Z9 13
U1 0
U2 4
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1476-511X
J9 LIPIDS HEALTH DIS
JI Lipids Health Dis.
PD DEC 7
PY 2014
VL 13
AR 185
DI 10.1186/1476-511X-13-185
PG 8
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA AX5BP
UT WOS:000346942500001
PM 25481429
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Harrell, JW
   Schrage, WG
AF Harrell, John W.
   Schrage, William G.
TI Cyclooxygenase-derived vasoconstriction restrains hypoxia-mediated
   cerebral vasodilation in young adults with metabolic syndrome
SO AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
LA English
DT Article
DE metabolic syndrome; cerebral blood flow; cyclooxygenase
ID BRAIN BLOOD-FLOW; OXIDATIVE STRESS; BREATHING STABILITY; NORTHERN
   MANHATTAN; STROKE; RISK; RATS; ARTERIES; ATHEROSCLEROSIS; INDOMETHACIN
AB Poor cerebrovascular function in metabolic syndrome (MetSyn) likely contributes to elevated risk of cerebrovascular disease in this growing clinical population. Younger MetSyn adults without clinical evidence of cerebrovascular disease exhibit preserved hypercapnic vasodilation yet markedly impaired hypoxic vasodilation, but the mechanisms behind reduced hypoxic vasodilation are unknown. Based on data from rats, we tested the hypothesis that younger adults with MetSyn exhibit reduced cerebral hypoxic vasodilation due to loss of vasodilating prostaglandins. Middle cerebral artery velocity (MCAv) was measured with transcranial Doppler ultrasound in adults with MetSyn (n = 13, 33 +/- 3 yr) and healthy controls (n = 15, 31 +/- 2 yr). Isocapnic hypoxia was induced by titrating inspired oxygen to lower arterial saturation to 90% and 80% for 5 min each. Separately, hypercapnia was induced by increasing end-tidal CO2 10 mmHg above baseline levels. Cyclooxygenase inhibition (100 mg indomethacin) was conducted in a randomized double-blind, placebo controlled design. MCAv was normalized for group differences in blood pressure (healthy: 89 +/- 2 mmHg vs. MetSyn: 102 +/- 2 mmHg) as cerebrovascular conductance index (CVCi), and used to assess cerebral vasodilation. Hypoxia increased CVCi in both groups; however, vasodilation was similar to 55% lower in MetSyn at SpO(2) = 80% (P < 0.05). Indomethacin tended to decrease hypoxic vasodilation in healthy controls, and unexpectedly increased dilation in MetSyn (P < 0.05). In contrast to hypoxia, hypercapnia-mediated vasodilation was similar between groups, as was the decrease in vasodilation with indomethacin. These data indicate increased production of vasoconstrictor prostaglandins restrains hypoxic cerebral vasodilation in MetSyn, preventing them from responding appropriately to this important physiological stressor.
C1 [Harrell, John W.; Schrage, William G.] Univ Wisconsin, Dept Kinesiol, Bruno Balke Biodynam Lab, Madison, WI 53706 USA.
C3 University of Wisconsin System; University of Wisconsin Madison
RP Schrage, WG (corresponding author), Univ Wisconsin, Dept Kinesiol, 1149A Natatorium, Madison, WI 53706 USA.
EM wschrage@education.wisc.edu
FU American Heart Association [11PRE7390038]; National Institutes of Health
   [HL-105820]; University of Wisconsin School of Medicine and Public
   Health Shapiro Summer Research Program; American Heart Association (AHA)
   [11PRE7390038] Funding Source: American Heart Association (AHA)
FX Funding for this project was provided by the American Heart Association
   (11PRE7390038, J. W. Harrell), National Institutes of Health (HL-105820,
   W. G. Schrage), and the University of Wisconsin School of Medicine and
   Public Health Shapiro Summer Research Program.
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NR 35
TC 13
Z9 16
U1 0
U2 2
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0363-6135
EI 1522-1539
J9 AM J PHYSIOL-HEART C
JI Am. J. Physiol.-Heart Circul. Physiol.
PD JAN
PY 2014
VL 306
IS 2
BP H261
EP H269
DI 10.1152/ajpheart.00709.2013
PG 9
WC Cardiac & Cardiovascular Systems; Physiology; Peripheral Vascular
   Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Physiology
GA 293PG
UT WOS:000329984300012
PM 24213610
OA Green Published
DA 2025-06-11
ER

PT J
AU Durak, A
   Olgar, Y
   Degirmenci, S
   Akkus, E
   Tuncay, E
   Turan, B
AF Durak, Aysegul
   Olgar, Yusuf
   Degirmenci, Sinan
   Akkus, Erman
   Tuncay, Erkan
   Turan, Belma
TI A SGLT2 inhibitor dapagliflozin suppresses prolonged
   ventricular-repolarization through augmentation of mitochondrial
   function in insulin-resistant metabolic syndrome rats
SO CARDIOVASCULAR DIABETOLOGY
LA English
DT Article
DE Diabetes; SGLT2 inhibitors; Heart function; Electrophysiology; Oxidative
   stress; Insulin resistance
ID OXIDATIVE STRESS; NA+/H+ EXCHANGER; DYSFUNCTION; HEART; EMPAGLIFLOZIN;
   OBESITY; CARDIOMYOCYTES; MORTALITY; ZN2+; PATHOPHYSIOLOGY
AB Background: Metabolic syndrome (MetS) is a prevalent risk factor for cardiac dysfunction. Although SGLT2-inhibitors have important cardioprotective effects in hyperglycemia, their underlying mechanisms are complex and not completely understood. Therefore, we examined mechanisms of a SGLT2-inhibitor dapagliflozin (DAPA)-related cardioprotection in overweight insulin-resistant MetS-rats comparison with insulin (INSU), behind its glucose-lowering effect.
   Methods: A 28-week high-carbohydrate diet-induced MetS-rats received DAPA (5 mg/kg), INSU (0.15 mg/kg) or vehicle for 2 weeks. To validate MetS-induction, we monitored all animals weekly by measuring body weight, blood glucose and HOMO-IR index, electrocardiograms, heart rate, systolic and diastolic pressures.
   Results: DAPA-treatment of MetS-rats significantly augmented the increased blood pressure, prolonged Q-R interval, and low heart rate with depressed left ventricular function and relaxation of the aorta. Prolonged-action potentials were preserved with DAPA-treatment, more prominently than INSU-treatment, at most, through the augmentation in depressed voltage-gated K+-channel currents. DAPA, more prominently than INSU-treatment, preserved the depolarized mitochondrial membrane potential, and altered mitochondrial protein levels such as Mfn-1, Mfn-2, and Fis-1 as well as provided significant augmentation in cytosolic Ca2+-homeostasis. Furthermore, DAPA also induced significant augmentation in voltage-gated Na+-currents and intracellular pH, and the cellular levels of increased oxidative stress, protein-thiol oxidation and ADP/ATP ratio in cardiomyocytes from MetS rats. Moreover, DAPA-treatment normalized the increases in the mRNA level of SGLT2 in MetS-rat heart.
   Conclusions: Overall, our data provided a new insight into DAPA-associated cardioprotection in MetS rats, including suppression of prolonged ventricular-repolarization through augmentation of mitochondrial function and oxidative stress followed by improvement of fusion-fission proteins, out of its glucose-lowering effect.
C1 [Durak, Aysegul; Olgar, Yusuf; Degirmenci, Sinan; Tuncay, Erkan; Turan, Belma] Ankara Univ, Dept Biophys, Fac Med, Ankara, Turkey.
   [Akkus, Erman] Ankara Univ, Fac Med, Internal Med, Ankara, Turkey.
C3 Ankara University; Ankara University
RP Turan, B (corresponding author), Ankara Univ, Dept Biophys, Fac Med, Ankara, Turkey.
EM belma.turan@medicine.ankara.edu.tr
RI olğar, yusuf/I-8960-2016; durak, aysegul/AAA-7647-2022; TUNCAY,
   ERKAN/AAG-8065-2020; TURAN, Belma/AAG-8084-2020; Akkus,
   Erman/ADT-1337-2022; Değirmenci, Sinan/M-7694-2013
OI TUNCAY, ERKAN/0000-0002-6675-2534; TURAN, Belma/0000-0003-2583-9294;
   OLGAR, YUSUF/0000-0002-3226-7450
FU TUBITAK [SBAG-214S254]
FX This study was supported by TUBITAK SBAG-214S254 to BT.
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NR 54
TC 129
Z9 139
U1 0
U2 24
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1475-2840
J9 CARDIOVASC DIABETOL
JI Cardiovasc. Diabetol.
PD NOV 17
PY 2018
VL 17
AR 144
DI 10.1186/s12933-018-0790-0
PG 17
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism
GA HA8HB
UT WOS:000450528800001
PM 30447687
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Rector, RS
   Warner, SO
   Liu, Y
   Hinton, PS
   Sun, GY
   Cox, RH
   Stump, CS
   Laughlin, MH
   Dellsperger, KC
   Thomas, TR
AF Rector, R. Scott
   Warner, Shana O.
   Liu, Ying
   Hinton, Pamela S.
   Sun, Grace Y.
   Cox, Richard H.
   Stump, Craig S.
   Laughlin, M. Harold
   Dellsperger, Kevin C.
   Thomas, Tom R.
TI Exercise and diet induced weight loss improves measures of oxidative
   stress and insulin sensitivity in adults with characteristics of the
   metabolic syndrome
SO AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
LA English
DT Article
DE insulin resistance; oxidized low; density lipoprotein; paraoxonase-1;
   energy restriction
ID LOW-DENSITY-LIPOPROTEIN; CORONARY-ARTERY-DISEASE; SHORT-TERM DIET;
   CHOLESTEROL SUBFRACTIONS; PARAOXONASE ACTIVITY; DIABETES-MELLITUS; HDL
   CHOLESTEROL; PLASMA-GLUCOSE; PARTICLE-SIZE; OXIDIZED LDL
AB Obesity and insulin resistance (IR) increase the risk for coronary heart disease; however, much of this risk is not attributable to traditional risk factors. We sought to determine whether weight loss associated with supervised aerobic exercise beneficially alters biomarkers of oxidative stress and whether these alterations are associated with improvements in measures of insulin resistance. Twenty-five sedentary and overweight to obese [body mass index (BMI) = 33.0 +/- 0.8 kg/m(2)] individuals, with characteristics of the metabolic syndrome, participated in a 4- to 7-mo weight loss program that consisted of energy restriction (reduced by similar to 500 kcal/day) and supervised aerobic exercise (5 days/wk, 45 min/day at 60% Vo(2) max; similar to 375 kcal/day). IR and insulin sensitivity were assessed by the calculation of the homeostasis model assessment (HOMA) and quantitative insulin sensitivity check index (QUICKI), respectively. Oxidative stress was assessed by oxidized LDL (oxLDL), myeloperoxidase (MPO), and low- and high-density lipoprotein (LDL and HDL) lipid hydroperoxide concentrations in serum. Indexes for antioxidative status included apolipoprotein A1 (apoA1) concentrations and paraoxonase-1 (PON1) activity and protein concentrations. Exercise- and diet-induced weight loss (similar to 10%) significantly (P < 0.05) increased insulin sensitivity and reduced IR, oxLDL, and LDL lipid hydroperoxides but did not alter HDL lipid hydroperoxides or MPO concentrations. Lifestyle modification impacted systemic antioxidative status by increasing apoA1 concentrations and reducing serum PON1 protein and activity. Changes in oxidative stress were not associated with alterations in HOMA or QUICKI. Diet- and exercise- induced weight loss (similar to 10%) improves measures of insulin sensitivity and beneficially alters biomarkers of oxidative status.
C1 Univ Missouri, Dept Nutr Sci, Exercise Physiol Program, Columbia, MO 65211 USA.
   Univ Missouri, Dept Biochem, Columbia, MO 65211 USA.
   Univ Missouri, Sch Educ, Columbia, MO 65211 USA.
   Univ Missouri, Dept Biomed Sci, Columbia, MO 65211 USA.
   Univ Missouri, Dept Internal Med, Columbia, MO 65211 USA.
   Univ Missouri, Dept Med Pharmacol & Physiol, Columbia, MO 65211 USA.
   Univ Arizona, Ctr Diabet Res, Dept Med, Tucson, AZ 85721 USA.
C3 University of Missouri System; University of Missouri Columbia;
   University of Missouri System; University of Missouri Columbia;
   University of Missouri System; University of Missouri Columbia;
   University of Missouri System; University of Missouri Columbia;
   University of Missouri System; University of Missouri Columbia;
   University of Missouri System; University of Missouri Columbia;
   University of Arizona
RP Thomas, TR (corresponding author), Univ Missouri, Dept Nutr Sci, Exercise Physiol Program, Columbia, MO 65211 USA.
EM thomastr@missouri.edu
OI Hinton, Pamela/0000-0003-0979-0451; Rector, R. Scott/0000-0001-9908-7123
FU NHLBI NIH HHS [R01 HL036088] Funding Source: Medline; NIAMS NIH HHS [T32
   AR48523, T32 AR048523] Funding Source: Medline; NIDDK NIH HHS [R0I
   DK67036, R01 DK067036] Funding Source: Medline
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NR 43
TC 103
Z9 118
U1 0
U2 2
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0193-1849
EI 1522-1555
J9 AM J PHYSIOL-ENDOC M
JI Am. J. Physiol.-Endocrinol. Metab.
PD AUG
PY 2007
VL 293
IS 2
BP E500
EP E506
DI 10.1152/ajpendo.00116.2007
PG 7
WC Endocrinology & Metabolism; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Physiology
GA 196CA
UT WOS:000248458100009
PM 17473052
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Braun, JM
   Buckley, JP
   Cecil, KM
   Chen, AM
   Kalkwarf, HJ
   Lanphear, BP
   Xu, YY
   Woeste, A
   Yolton, K
AF Braun, Joseph M.
   Buckley, Jessie P.
   Cecil, Kim M.
   Chen, Aimin
   Kalkwarf, Heidi J.
   Lanphear, Bruce P.
   Xu, Yingying
   Woeste, Anastasia
   Yolton, Kimberly
TI Adolescent follow-up in the Health Outcomes and Measures of the
   Environment (HOME) Study: cohort profile
SO BMJ OPEN
LA English
DT Article
DE epidemiology; paediatrics; toxicology
ID BISPHENOL-A EXPOSURE; PHYSICAL-ACTIVITY; PRENATAL EXPOSURE;
   UNITED-STATES; CORD BLOOD; CHILDREN; BIRTH; AGE; DISORDERS; DISEASE
AB Purpose Environmental chemical exposures may adversely affect an array of adolescent health outcomes. Thus, we used the Health Outcomes and Measures of the Environment (HOME) study, a prospective cohort that recruited pregnant women and conducted longitudinal follow-up on children over the first 12 years of life, to determine if and when chemical exposures affect adolescent health.
   Participants We recruited 468 pregnant women (age range: 18-45 years) from the Cincinnati, Ohio region to participate in a cohort study between March 2003 and January 2006. Follow-up included two clinic and one home visits during pregnancy, a delivery hospital visit, and four home and six clinic visits when children were aged 4 weeks and 1, 2, 3, 4, 5 and 8 years. Of 441 children available for follow-up, 396 (90%) completed at least one follow-up and 256 (58%) completed the most recent follow-up at 12 years of age (range: 11-14).
   Findings to date Our new measures include maternal/child report of internalising symptoms, neuroimaging, dual-energy X-ray absorptiometry-derived estimates of lean/adipose tissue and bone mineral density, and cardiometabolic risk biomarkers. We assessed adolescent exposure to perfluoroalkyl substances, phenols, phthalates and flame retardants. Participants completing follow-up at 12 years of age were similar to the original cohort in terms of baseline factors. Most children had typical and expected values for this age on measures of internalising symptoms, body composition, bone density and cardiometabolic risk markers. Notably, 36% and 11% of children had scores indicative of potential anxiety and depressive disorders, respectively. Approximately 35% of children were overweight or obese, with higher prevalence among girls. Thirty-three per cent of children had borderline or high triglyceride concentrations (>90 mg/dL).
   Future plans We will examine associations of early life environmental chemical exposures with adolescent health measures while considering potential periods of heightened susceptibility and mixture effects.
C1 [Braun, Joseph M.] Brown Univ, Dept Epidemiol, Providence, RI 02912 USA.
   [Buckley, Jessie P.] Johns Hopkins Univ, Dept Environm Hlth & Engn, Bloomberg Sch Publ Hlth, Baltimore, MD USA.
   [Cecil, Kim M.] Cincinnati Childrens Hosp Med Ctr, Dept Radiol, Cincinnati, OH 45229 USA.
   [Chen, Aimin] Univ Penn, Dept Biostat Epidemiol & Informat, Philadelphia, PA 19104 USA.
   [Kalkwarf, Heidi J.; Xu, Yingying; Woeste, Anastasia; Yolton, Kimberly] Cincinnati Childrens Hosp Med Ctr, Dept Pediat, Cincinnati, OH 45229 USA.
   [Lanphear, Bruce P.] Simon Fraser Univ, Fac Hlth Sci, Burnaby, BC, Canada.
C3 Brown University; Johns Hopkins University; Johns Hopkins Bloomberg
   School of Public Health; Cincinnati Children's Hospital Medical Center;
   University of Pennsylvania; Cincinnati Children's Hospital Medical
   Center; Simon Fraser University
RP Braun, JM (corresponding author), Brown Univ, Dept Epidemiol, Providence, RI 02912 USA.
EM joseph_braun_1@brown.edu; kimberly.yolton@cchmc.org
RI Yunkunis, Kimberly/AAO-5605-2021
OI Yolton, Kimberly/0000-0002-4458-0516
FU National Institutes of Environmental Health Sciences [R01 ES027224, R01
   ES025214, R01 ES028277, R01 ES030078, R01 ES024381, R01 ES020349, P01
   ES011261, R01 ES014575, R01 ES015517]
FX The HOME Study was funded by National Institutes of Environmental Health
   Sciences grants R01 ES027224, R01 ES025214, R01 ES028277, R01 ES030078,
   R01 ES024381, R01 ES020349, P01 ES011261, R01 ES014575, and R01
   ES015517.
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NR 76
TC 49
Z9 50
U1 1
U2 7
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2044-6055
J9 BMJ OPEN
JI BMJ Open
PY 2020
VL 10
IS 5
AR e034838
DI 10.1136/bmjopen-2019-034838
PG 11
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA NQ7LS
UT WOS:000571051700004
PM 32385062
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Lu, LJ
   Zhao, D
   Li, C
   Sun, YY
   Geng, FX
   Zhang, SW
   Li, WQ
   Wang, SL
   Pan, YP
AF Lu, Lijie
   Zhao, Dan
   Li, Chen
   Sun, Yangyang
   Geng, Fengxue
   Zhang, Shuwei
   Li, Weiqi
   Wang, Songlin
   Pan, Yaping
TI The role of periodontitis in the development of atherosclerotic
   cardiovascular disease in participants with the components of metabolic
   syndrome: a systematic review and meta-analysis
SO CLINICAL ORAL INVESTIGATIONS
LA English
DT Article
DE Periodontitis; Metabolic syndrome; Cardiovascular disease;
   Arteriosclerosis; Dysglycemia
ID CORONARY-HEART-DISEASE; OXIDATIVE STRESS; INSULIN-RESISTANCE;
   RISK-FACTORS; GLOBAL BURDEN; BONE LOSS; ASSOCIATION; OBESITY; HEALTH;
   PREVALENCE
AB Objectives Prevention of atherosclerotic cardiovascular disease (ASCVD) is important in individuals with metabolic syndrome components (MetS), and periodontitis may play an important role in this process. This study aims to evaluate the association between periodontitis and ASCVD in participants with the components of MetS, including obesity, dysglycemia, hypertension, and dyslipidemia. Materials and methods This study conducted followed the MOOSE reporting guidelines and the PRISMA 2020 guidelines. EMBASE, MEDLINE, Web of Science, Cochrane Library, PubMed and OpenGrey were searched for observational studies about the linkage of periodontitis to ASCVD in people with MetS components up to April 9, 2023. Cohort, case-control and cross-sectional studies were included after study selection. Quality evaluation was carried out using the original and modified Newcastle-Ottawa Scale as appropriate. Random-effects model was employed for meta-analysis. Results Nineteen studies were finally included in the quality analysis, and all of them were assessed as moderate to high quality. Meta-analyses among fifteen studies revealed that the participants with periodontitis were more likely to develop ASCVD in those who have dysglycemia (RR = 1.25, 95% CI = 1.13-1.37; p < 0.05), obesity (RR = 1.13, 95% CI = 1.02-1.24; p < 0.05), dyslipidemia (RR = 1.36, 95% CI = 1.13-1.65; p < 0.05), or hypertension (1.20, 95% CI = 1.05-1.36; p < 0.05). Conclusions Periodontitis promotes the development of ASCVD in participants with one MetS component (obesity, dysglycemia, hypertension or dyslipidemia). Clinical relevanceIn people with MetS components, periodontitis may contribute to the ASCVD incidence.
C1 [Lu, Lijie; Li, Chen; Sun, Yangyang; Geng, Fengxue; Zhang, Shuwei; Pan, Yaping] China Med Univ, Sch & Hosp Stomatol, Dept Periodont, Shenyang, Peoples R China.
   [Lu, Lijie; Li, Chen; Sun, Yangyang; Geng, Fengxue; Zhang, Shuwei; Pan, Yaping] Liaoning Prov Key Lab Oral Dis, Shenyang, Peoples R China.
   [Zhao, Dan] Capital Med Univ, Beijing Stomatol Hosp, Dept Implant Dent, Beijing, Peoples R China.
   [Wang, Songlin] Capital Med Univ, Salivary Gland Dis Ctr, Beijing Key Lab Tooth Regenerat & Funct Reconstruc, Beijing 100050, Peoples R China.
   [Wang, Songlin] Capital Med Univ, Beijing Stomatol Hosp, Beijing 100050, Peoples R China.
   [Li, Weiqi] Sichuan Univ, West China Hosp Stomatol, Chinese Acad Med Sci,Res Unit Oral Carcinogenesis, Natl Clin Res Ctr Oral Dis,State Key Lab Oral Dis, Chengdu, Peoples R China.
C3 China Medical University; Capital Medical University; Capital Medical
   University; Capital Medical University; Sichuan University; Chinese
   Academy of Medical Sciences - Peking Union Medical College
RP Pan, YP (corresponding author), China Med Univ, Sch & Hosp Stomatol, Dept Periodont, Shenyang, Peoples R China.; Pan, YP (corresponding author), Liaoning Prov Key Lab Oral Dis, Shenyang, Peoples R China.; Wang, SL (corresponding author), Capital Med Univ, Salivary Gland Dis Ctr, Beijing Key Lab Tooth Regenerat & Funct Reconstruc, Beijing 100050, Peoples R China.; Wang, SL (corresponding author), Capital Med Univ, Beijing Stomatol Hosp, Beijing 100050, Peoples R China.
EM slwang@ccmu.edu.cn; yppan@cmu.edu.cn
RI Zhao, Dan/LIR-1489-2024; Li, Weiqi/KEH-5075-2024; 孙, 洋洋/JPA-6465-2023
OI Zhao, Dan/0000-0002-0037-1464
FU Beijing Stomatological Hospital, Capital Medical University Young
   Scientist Program
FX No Statement Available
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NR 104
TC 2
Z9 2
U1 2
U2 4
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1432-6981
EI 1436-3771
J9 CLIN ORAL INVEST
JI Clin. Oral Investig.
PD MAY 27
PY 2024
VL 28
IS 6
AR 339
DI 10.1007/s00784-024-05731-1
PG 14
WC Dentistry, Oral Surgery & Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dentistry, Oral Surgery & Medicine
GA SG7J3
UT WOS:001233365800002
PM 38801482
DA 2025-06-11
ER

PT J
AU Hsu, CC
   Cheng, KC
   Li, YX
   Hsu, PH
   Cheng, JT
   Niu, HS
AF Hsu, Chia-Chen
   Cheng, Kai-Chun
   Li, Yingxiao
   Hsu, Ping-Hao
   Cheng, Juei-Tang
   Niu, Ho-Shan
TI TGR5 Expression Is Associated with Changes in the Heart and Urinary
   Bladder of Rats with Metabolic Syndrome
SO LIFE-BASEL
LA English
DT Article
DE metabolic syndrome; TGR5; etanercept; heart; urinary bladder; rats
ID TUMOR-NECROSIS-FACTOR; TRANSCRIPTION 3; SIGNAL TRANSDUCER; OXIDATIVE
   STRESS; INFLAMMATION; ACTIVATOR; OBESITY; ACID; ETANERCEPT; MODEL
AB Adipose-derived cytokines may contribute to the inflammation that occurs in metabolic syndrome (MetS). The Takeda G protein-coupled receptor (TGR5) regulates energy expenditure and affects the production of pro-inflammatory biomarkers in metabolic diseases. Etanercept, which acts as a tumor necrosis factor (TNF)-alpha antagonist, can also block the inflammatory response. Therefore, the interaction between TNF-alpha and TGR5 expression was investigated in rats with high-fat diet (HFD)-induced obesity. Heart tissues isolated from the HFD-induced MetS rats were analyzed. Changes in TGR5 expression were investigated with lithocholic acid (LCA) as the agonist. Betulinic acid (BA) was used to activate TGR5 in urinary bladders. LCA was more effective in the heart tissues of HFD-fed rats, although etanercept alleviated the function of LCA. STAT3 activation and higher TGR5 expression were observed in the heart tissues collected from HFD-fed rats. Thus, cardiac TGR5 expression is promoted by HFD through STAT3 activation in rats. Moreover, the urinary bladders of female rats fed a HFD showed a low response, which was reversed by etanercept. Relaxation by BA in the bladders was more marked in HFD-fed rats. The high TGR5 expression in HFD-fed rats was characterized using a mRNA assay, and the increased cAMP levels were found to be stimulated by BA in the isolated bladders. Therefore, TGR5 expression increases with a HFD in both the hearts and urinary bladders. Collectively, cytokine-medicated TGR5 activation was observed in the hearts and urinary bladders of rats.
C1 [Hsu, Chia-Chen] Chang Gung Univ Sci & Technol, Grad Inst Gerontol & Hlth Care Management, Taoyuan 33303, Taiwan.
   [Hsu, Chia-Chen] Taipei City Hosp, Dept Otorhinolaryngol, Taipei 10341, Taiwan.
   [Hsu, Chia-Chen] Univ Taipei, Dept Exercise & Hlth Sci, Taipei 11153, Taiwan.
   [Cheng, Kai-Chun] Tajen Univ, Coll Pharm, Dept Pharm, Pingtung 90741, Taiwan.
   [Cheng, Kai-Chun] Kagoshima Univ, Grad Sch Med & Dent Sci, Dept Psychosomat Internal Med, Pharmacol Dept Herbal Med, Kagoshima 8908544, Japan.
   [Li, Yingxiao; Niu, Ho-Shan] Tzu Chi Univ Sci & Technol, Dept Nursing, Hualien 970302, Taiwan.
   [Hsu, Ping-Hao] Chung Shan Med Univ, Sch Med, Taichung 40201, Taiwan.
   [Cheng, Juei-Tang] Chi Mei Med Ctr, Dept Med Res, Tainan 71004, Taiwan.
C3 Chang Gung University of Science & Technology; Taipei City Hospital;
   University of Taipei; Kagoshima University; Chung Shan Medical
   University; Chi Mei Hospital
RP Niu, HS (corresponding author), Tzu Chi Univ Sci & Technol, Dept Nursing, Hualien 970302, Taiwan.
EM eardoctorhsu@yahoo.com.tw; kc-cheng@tajen.edu.tw;
   sc145@ems.tcust.edu.tw; andy30817@gmail.com; jtcheng5503@gmail.com;
   ts00@ems.tcust.edu.tw
RI CHEN, JUI-YI/AAV-8854-2021; Cheng, Kai-Chun/LIG-6306-2024
OI Kai Chun, Cheng/0000-0003-4983-4666
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NR 46
TC 3
Z9 4
U1 0
U2 5
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2075-1729
J9 LIFE-BASEL
JI Life-Basel
PD JUL
PY 2021
VL 11
IS 7
AR 695
DI 10.3390/life11070695
PG 14
WC Biology; Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics; Microbiology
GA TO3PN
UT WOS:000676828200001
PM 34357066
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Sewani-Rusike, CR
   Buso, A
   Engwa, GA
   Nkeh-Chungag, BN
AF Sewani-Rusike, Constance R.
   Buso, Andiswa
   Engwa, Godwill A.
   Nkeh-Chungag, Benedicta N.
TI In utero exposure to Hypoxis hemerocallidea Fisch., C.A.Mey. &
   Ave-Lall. improves metabolic syndrome parameters in pregnant rats and
   offspring
SO JOURNAL OF PHARMACY & PHARMACOGNOSY RESEARCH
LA English
DT Article
DE Hypoxis hemerocallidea; intrauterine programming; insulin resistance;
   metabolic syndrome
ID POTATO AQUEOUS EXTRACT; INSULIN-RESISTANCE; BIRTH-WEIGHT; OBESITY; DIET;
   EXPRESSION; CHILDHOOD; STRESS; PLANTS; RISK
AB Context: Intrauterine and early life environments contribute to adult metabolic phenotype. Use of medicinal plants like Hypoxis hemerocallidea during pregnancy raises the question of whether this species may have epigenetic benefits or detriments due to intrauterine-programming, which is phenotypically expressed in the offspring.
   Aims: To evaluate the effect of H. hemerocallidea on selected markers of metabolic syndrome on dams and their pups (offspring).
   Methods: Pregnant female Wistar rats (n=18) were divided into three treatment groups (n=6/group): Ethanol extract of H. hemerocallidea at 150 and 300 mg/kg b.w and the control (distilled water) were administered for 21 days. Body weights were monitored and oral glucose tolerance was determined for dams on day 20 of gestation and for pups 28 days postpartum. Serum total antioxidant capacity (TAC), LDL and HDL were determined 28 days postpartum.
   Results: H. hemerocallidea had no effect on body and organ weights of the treated dams. Pups born to H. hemerocallidea dams had reduced visceral fat compared to the untreated controls. H. hemerocallidea increased the glucose tolerance of treated dams and their pups compared to untreated controls. H. hemerocallidea extract increased serum HDL in treated dams while it decreased LDL in pups born to treated dams. H. hemerocallidea increased TAC in pups born to treated dams.
   Conclusions: H. hemerocallidea protected pregnant dams and their pups from insulin resistance, improved lipid profiles, reduced visceral fat accumulation and boosted total antioxidant capacity in pups. These protective effects of H. hemerocallidea in pups may have resulted from intrauterine programming during pregnancy.
C1 [Sewani-Rusike, Constance R.; Buso, Andiswa] Walter Sisulu Univ, Fac Hlth Sci, Dept Human Biol, PBX1, ZA-5117 Mthatha, South Africa.
   [Engwa, Godwill A.; Nkeh-Chungag, Benedicta N.] Walter Sisulu Univ, Fac Nat Sci, Dept Biol & Environm Sci, PBX1, ZA-5117 Mthatha, South Africa.
C3 Walter Sisulu University; Walter Sisulu University
RP Sewani-Rusike, CR (corresponding author), Walter Sisulu Univ, Fac Hlth Sci, Dept Human Biol, PBX1, ZA-5117 Mthatha, South Africa.
EM crusike@wsu.ac.za
RI Chungag, Benedicta/AAU-8632-2021; Engwa, Godwill/T-1577-2017
OI Sewani-Rusike, Constance/0000-0002-3295-2933
FU South African Medical Research Council (SAMRC)
FX Authors acknowledge the South African Medical Research Council (SAMRC)
   for funding through the Self-Initiated Research (SIR) grant awarded to
   C.R. Sewani-Rusike (MRCRusike).
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NR 57
TC 0
Z9 0
U1 0
U2 6
PU JOURNAL PHARMACY & PHARMACOGNOSY RESEARCH-JPPRES
PI ANTOFAGASTA
PA ANGAMOS 0610, ANTOFAGASTA, 00000, CHILE
SN 0719-4250
J9 J PHARM PHARMACOGN R
JI J. Pharm. Pharmacogn. Res.
PD MAR-APR
PY 2021
VL 9
IS 2
BP 113
EP 125
PG 13
WC Pharmacology & Pharmacy
WE Emerging Sources Citation Index (ESCI)
SC Pharmacology & Pharmacy
GA PB1PK
UT WOS:000596101200001
DA 2025-06-11
ER

PT J
AU Wang, O
   Liu, J
   Cheng, Q
   Guo, XX
   Wang, Y
   Zhao, L
   Zhou, F
   Ji, BP
AF Wang, Ou
   Liu, Jia
   Cheng, Qian
   Guo, Xiaoxuan
   Wang, Yong
   Zhao, Liang
   Zhou, Feng
   Ji, Baoping
TI Effects of Ferulic Acid and γ-Oryzanol on High-Fat and High-Fructose
   Diet-Induced Metabolic Syndrome in Rats
SO PLOS ONE
LA English
DT Article
ID ENDOPLASMIC-RETICULUM STRESS; RICE BRAN OIL; INSULIN-RESISTANCE; PLANT
   STEROLS; HEPATIC STEATOSIS; CARDIOVASCULAR RISK; HIGH-CARBOHYDRATE;
   LIPID-METABOLISM; LIVER-DISEASE; HEPG2 CELLS
AB Background
   The high morbidity of metabolic dysfunction diseases has heightened interest in seeking natural and safe compounds to maintain optimal health. gamma-Oryzanol (OZ), the ferulic acid (FA) ester with phytosterols, mainly present in rice bran has been shown to improve markers of metabolic syndrome. This study investigates the effects of FA and OZ on alleviating high-fat and high-fructose diet (HFFD)-induced metabolic syndrome parameters.
   Methods
   Male SD rats were fed with a regular rodent diet, HFFD, or HFFD supplemented with 0.05% FA or 0.16% OZ (equimolar concentrations) for 13 weeks. Food intake, organ indices, serum lipid profiles, glucose metabolism, insulin resistance (IR) index and cytokine levels were analyzed. The mechanisms were further investigated in oleic acid-stimulated HepG2 cells by analyzing triglyceride (TG) content and lipogenesis-related gene expressions.
   Results
   In the in vivo study, FA and OZ exhibited similar effects in alleviating HFFD-induced obesity, hyperlipidemia, hyperglycemia, and IR. However, only OZ treatment significantly decreased liver index and hepatic TG content, lowered serum levels of C-reactive protein and IL-6, and increased serum concentration of adiponectin. In the in vitro assay, only OZ administration significantly inhibited intracellular TG accumulation and down-regulated expression of stearoyl coenzyme-A desaturase-1, which might facilitate OZ to enhance its hepatoprotective effect.
   Conclusion
   OZ is more effective than FA in inhibiting hepatic fat accumulation and inflammation. Thus, FA and OZ could be used as dietary supplements to alleviate the deleterious effects of HFFD.
C1 [Wang, Ou; Cheng, Qian; Guo, Xiaoxuan; Wang, Yong; Zhao, Liang; Zhou, Feng; Ji, Baoping] China Agr Univ, Coll Food Sci & Nutr Engn, Beijing, Peoples R China.
   [Liu, Jia] China Natl Res Inst Food & Fermentat Ind, Beijing, Peoples R China.
C3 China Agricultural University
RP Ji, BP (corresponding author), China Agr Univ, Coll Food Sci & Nutr Engn, Beijing, Peoples R China.
EM jibp330@hotmail.com
RI Wang, Ou/AAE-1806-2022
OI Zhao, Liang/0000-0003-2542-9279
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NR 54
TC 110
Z9 117
U1 0
U2 46
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD FEB 3
PY 2015
VL 10
IS 2
AR e0118135
DI 10.1371/journal.pone.0118135
PG 14
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA CA3QZ
UT WOS:000348822600100
PM 25646799
OA gold, Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Moon, SS
AF Moon, Seong-Su
TI Additive effect of heavy metals on metabolic syndrome in the Korean
   population: the Korea National Health and Nutrition Examination Survey
   (KNHANES) 2009-2010
SO ENDOCRINE
LA English
DT Article
DE Metabolic syndrome; Heavy metal; Lead; Mercury; Cadmium; Endocrine
   disruptors
ID PERSISTENT ORGANIC POLLUTANTS; ENDOCRINE-DISRUPTING CHEMICALS;
   CARDIOVASCULAR-DISEASE; OXIDATIVE STRESS; SERUM CONCENTRATIONS;
   DIABETES-MELLITUS; BLOOD-PRESSURE; LEAD; CADMIUM; EXPOSURE
AB There have been increasing concerns regarding health problems due to endocrine disrupting chemicals (EDCs). We investigated association of heavy metals, including lead, mercury, and cadmium, with metabolic syndrome (MS) and its individual components in the Korean population. Participants included 1,961 males and 1,989 females 20 years of age or older from the fourth and fifth Korea National Health and Nutritional Examination Surveys of the Korean population (2009 and 2010). We examined the relationship of blood lead, mercury, and cadmium levels with MS and the additive effect of three heavy metals on MS after adjustment for age, sex, body mass index (BMI), region, smoking, alcohol consumption, and regular exercise. Blood concentration of lead showed a significant but modest association with prevalence of MS (P = 0.04). Other heavy metals did not show such a relationship with MS. When the participants were classified according to the sum of category numbers of the three heavy metals, adjusted odds ratios were 1.0, 1.355, 1.638, and 1.556 (P < 0.01). Among components of MS, significant relationship of the sum of heavy metals with hypertension and elevated triglyceride was demonstrated. Blood concentration of lead was positively associated with the prevalence of MS. Of particular interest, cumulative effect of a mixture of lead, mercury, and cadmium on prevalence of MS was stronger than the sum of effect of each heavy metal. Accumulative effect of exposure to heavy metals could be more additive or synergistic than individual exposure in the general population.
C1 [Moon, Seong-Su] Dongguk Univ, Coll Med, Dept Internal Med, Gyeongju 780350, Gyeongbuk Provi, South Korea.
   [Moon, Seong-Su] Dongguk Univ, Inst Med, Gyeongju 780350, Gyeongbuk Provi, South Korea.
C3 Dongguk University; Dongguk University
RP Moon, SS (corresponding author), Dongguk Univ, Coll Med, Dept Internal Med, Dongdae Ro 87, Gyeongju 780350, Gyeongbuk Provi, South Korea.
EM drmoonss@hanmail.net
FU Daegu and Kyungpook local committee of the Korean Diabetes Association;
   Dongguk University research fund
FX This research was supported by a grant from the Daegu and Kyungpook
   local committee of the Korean Diabetes Association and by the Dongguk
   University research fund.
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NR 42
TC 70
Z9 78
U1 2
U2 33
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1355-008X
EI 1559-0100
J9 ENDOCRINE
JI Endocrine
PD JUN
PY 2014
VL 46
IS 2
BP 263
EP 271
DI 10.1007/s12020-013-0061-5
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA AI6IU
UT WOS:000336977400015
PM 24065312
DA 2025-06-11
ER

PT J
AU Barona, J
   Jones, JJ
   Kopec, RE
   Comperatore, M
   Andersen, C
   Schwartz, SJ
   Lerman, RH
   Fernandez, ML
AF Barona, Jacqueline
   Jones, Jennifer J.
   Kopec, Rachel E.
   Comperatore, Michael
   Andersen, Catherine
   Schwartz, Steven J.
   Lerman, Robert H.
   Fernandez, Maria Luz
TI A Mediterranean-style low-glycemic-load diet increases plasma
   carotenoids and decreases LDL oxidation in women with metabolic syndrome
SO JOURNAL OF NUTRITIONAL BIOCHEMISTRY
LA English
DT Article
DE Mediterranean diet; Plasma carotenoids; Oxidized LDL; Metabolic syndrome
ID CARDIOVASCULAR RISK-FACTORS; LOW-DENSITY-LIPOPROTEIN; BETA-CAROTENE;
   BIOMARKERS; CHOLESTEROL; VEGETABLES; FRUITS; ASSOCIATIONS; RESISTANCE;
   ADHERENCE
AB Thirty-five women with metabolic syndrome and high plasma low-density lipoprotein (LDL) cholesterol (>= 100 mg/dl) participated in a dietary intervention consisting of a Mediterranean-style low-glycemic-load diet for 12 weeks. Participants were randomly allocated to consume diet only (n=15) or diet plus a medical food containing soy protein and plant sterols (n=20). Plasma concentrations of carotenoids, lipoprotein subfractions and oxidized LDL (OxLDL) were measured. Independent of treatment, women had a significant increase in plasma lutein (P<.0001) and beta-carotene (P<.0001), while plasma lycopene was reduced (P<.05) after 12 weeks. Low-density lipoprotein cholesterol was reduced from 138 +/- 35 to 114 +/- 33 mg/dl (P<.0001). In addition, decreases were observed in the atherogenic subfractions: large very low-density lipoprotein (P<.05), small LDL (P<.00001) and medium high-density lipoprotein (P<.05). Oxidized LDL was significantly reduced by 12% in both groups (P<.01). Changes in OxLDL were inversely correlated with plasma lutein (r=-.478, P<.0001). The data indicate that women complied with the dietary regimen by increasing fruits and vegetable intake. Decreased consumption of high-glycemic foods frequently co-consumed with lycopene-rich tomato sauce such as pasta and pizza may be responsible for the lowering of this carotenoid in plasma after 12 weeks. These results also suggest that plasma lutein concentrations may protect against oxidative stress by reducing the concentrations of OxLDL (C) 2012 Elsevier Inc. All rights reserved.
C1 [Barona, Jacqueline; Jones, Jennifer J.; Comperatore, Michael; Andersen, Catherine; Fernandez, Maria Luz] Univ Connecticut, Dept Nutr Sci, Storrs, CT 06269 USA.
   [Barona, Jacqueline] Univ Antioquia, Escuela Microbiol, Medellin, Colombia.
   [Kopec, Rachel E.; Schwartz, Steven J.] Ohio State Univ, Dept Food Sci & Technol, Columbus, OH 43210 USA.
   [Lerman, Robert H.] Metagenics Inc, Funct Med Res Ctr, Gig Harbor, WA 98332 USA.
C3 University of Connecticut; Universidad de Antioquia; University System
   of Ohio; Ohio State University; Metagenics Inc.
RP Fernandez, ML (corresponding author), Univ Connecticut, Dept Nutr Sci, 3624 Horsebarn Rd Ext, Storrs, CT 06269 USA.
EM maria-luz.fernandez@uconn.edu
RI Acevedo, Maria/A-8759-2019; Kopec, Rachel/A-1533-2017
OI Kopec, Rachel/0000-0002-1368-6713; Barona Acevedo, Maria
   Jacqueline/0000-0002-0592-9324; Andersen, Catherine/0000-0001-9774-5030;
   Schwartz, Steven/0000-0002-1427-5780
FU Metagenics, Inc. (Gig Harbor, WA)
FX This study was supported by Metagenics, Inc. (Gig Harbor, WA).
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NR 40
TC 33
Z9 38
U1 0
U2 14
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0955-2863
EI 1873-4847
J9 J NUTR BIOCHEM
JI J. Nutr. Biochem.
PD JUN
PY 2012
VL 23
IS 6
BP 609
EP 615
DI 10.1016/j.jnutbio.2011.02.016
PG 7
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA 952IK
UT WOS:000304786000012
PM 21775117
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Langdon, KD
   Clarke, J
   Corbett, D
AF Langdon, K. D.
   Clarke, J.
   Corbett, D.
TI LONG-TERM EXPOSURE TO HIGH FAT DIET IS BAD FOR YOUR BRAIN: EXACERBATION
   OF FOCAL ISCHEMIC BRAIN INJURY
SO NEUROSCIENCE
LA English
DT Article
DE sensorimotor function; Western diet; high fat diet; stroke; animal
   models; metabolic syndrome
ID NEUROTROPHIC FACTOR; METABOLIC SYNDROME; CEREBRAL-ISCHEMIA; COGNITIVE
   PERFORMANCE; OXIDATIVE STRESS; RATS; PLASTICITY; EXERCISE;
   ATHEROSCLEROSIS; IMPAIRMENT
AB A diet consisting of high levels of saturated fat has been linked to a dramatic rise in obesity, type II diabetes, and metabolic syndrome. The effect of these co-morbidities on stroke outcome has not been examined in detail in human or animal studies. In this study we hypothesized that maintaining animals on a high fat, "Western diet" (WD), for an extended period would have a detrimental effect on ischemic outcome. Forty-eight male Sprague-Dawley rats were exposed to 1 month of either WD or control diets initiated at 6 weeks of age (Experiment 1) or 3 months of either WD or control diets initiated at 4 weeks of age (Experiment 2) prior to endothelin-1-induced ischemia. Following ischemia, animals were assessed in the staircase reaching and beam-traversing tests at 2 and 4 weeks post-ischemia and infarct volumes were calculated at 4 weeks post-ischemia. Analysis revealed no difference between animals exposed to either WD or control diets for 1 month in behavioral or histological assessments. In contrast, 3 months of WD diet exposure significantly increased functional impairments in both the staircase and beam-traversing tests as well as increasing the volume of infarction, primarily in the cortex. The results of this study demonstrate that long-term exposure to WD diets are detrimental to ischemic outcome. Consequently, it is important to incorporate disease co-morbidities and/or risk factors in pre-clinical evaluation of neuroprotective or restorative interventions if therapies are to be translated into the clinic. (C) 2011 IBRO. Published by Elsevier Ltd. All rights reserved.
C1 [Corbett, D.] Univ Ottawa, Fac Med, Dept Cellular & Mol Med, Ottawa, ON K1H 8M5, Canada.
   [Langdon, K. D.; Clarke, J.; Corbett, D.] Mem Univ Newfoundland, Fac Med, Div BioMed Sci, St John, NF A1B 3V6, Canada.
C3 University of Ottawa; Memorial University Newfoundland
RP Corbett, D (corresponding author), Univ Ottawa, Fac Med, Dept Cellular & Mol Med, 451 Smyth Rd, Ottawa, ON K1H 8M5, Canada.
EM dcorbett@uottawa.ca
RI Langdon, Kristopher/JDC-7276-2023; Corbett, Dale/D-6625-2011
OI Corbett, Dale/0000-0003-0217-4576
FU Canadian Institutes of Health Research; Canadian Stroke Network; Heart
   and Stroke Foundation of Canada/CIHR/Canadian Stroke
   Network/Astra-Zeneca Focus on Stroke; Natural Sciences and Engineering
   Research Council of Canada
FX The authors thank Suzanne Evans and Sara Dalley for help with behavioral
   assessments and Shirley Granter-Button and Garry Chernenko for their
   technical assistance. This work was supported by operating grants from
   the Canadian Institutes of Health Research and Canadian Stroke Network
   awarded to D. Corbett who holds a Canada Research Chair in Stroke and
   Neuroplasticity. KD Langdon was supported by the Heart and Stroke
   Foundation of Canada/CIHR/Canadian Stroke Network/Astra-Zeneca Focus on
   Stroke Doctoral Fellowship. J Clarke was supported by a doctoral
   fellowship from the Natural Sciences and Engineering Research Council of
   Canada.
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NR 31
TC 65
Z9 74
U1 0
U2 14
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4522
EI 1873-7544
J9 NEUROSCIENCE
JI Neuroscience
PD MAY 19
PY 2011
VL 182
BP 82
EP 87
DI 10.1016/j.neuroscience.2011.03.028
PG 6
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 762FP
UT WOS:000290460600007
PM 21435380
DA 2025-06-11
ER

PT J
AU Senturk, O
   Kocaman, O
   Hulagu, S
   Sahin, T
   Aygun, C
   Konduk, T
   Celebi, A
AF Senturk, O.
   Kocaman, O.
   Hulagu, S.
   Sahin, T.
   Aygun, C.
   Konduk, T.
   Celebi, A.
TI Endothelial dysfunction in Turkish patients with non-alcoholic fatty
   liver disease
SO INTERNAL MEDICINE JOURNAL
LA English
DT Article
DE cardiovascular complication; endothelial-dependent dilatation;
   endothelial-independent dilatation; non-alcoholic fatty liver disease
ID CORONARY-HEART-DISEASE; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   OXIDATIVE STRESS; RISK-FACTORS; CARDIOVASCULAR-DISEASE; NITRIC-OXIDE;
   STEATOHEPATITIS; GLUCOSE; ARTERY
AB Background: The components of the metabolic syndrome are closely related with endothelial dysfunction, which is a pathophysiological issue of cardiovascular diseases. Non-alcoholic fatty liver disease (NAFLD) is considered as one of the components of the metabolic syndrome. The aim of this study was to evaluate the endothelial-dependent dilatation (EDD) and endothelial-independent dilatation (EID) of the brachial artery in NAFLD.
   Methods: Fifteen non-alcoholic steatohepatitis (NASH), 17 patients with simple steatosis and 16 healthy subjects formed the study group. Non-alcoholic fatty liver disease group was composed of patients admitted to the gastroenterology outpatient clinic because of increased liver enzymes. Endothelial functions of the brachial artery were evaluated by vascular ultrasound. EDD was assessed by establishing reactive hyperaemia, and EID was determined by using sublingual nitrate.
   Results: No statistical difference for the basal diameter of brachial artery was found between the groups (P = 0.49). The values for EDD and EID were significantly different across all three groups (P < 0.0001 and P < 0.0001, respectively). EDD and EID were significantly lower in NASH compared with simple steatosis (P = 0.01 and P < 0.01, respectively). However, there was no statistical significance for EDD and EID in simple steatosis groups compared with controls (P = 0.58 and P = 0.98, respectively).
   Conclusions: Our study showed that patients with NASH had significantly worse endothelial dysfunction compared with patients with simple steatosis and healthy subjects. The treatment strategies with ameliorative effects for endothelial dysfunction might be effective for delaying the development of cardiovascular complications in NAFLD.
C1 [Senturk, O.; Kocaman, O.; Hulagu, S.; Aygun, C.; Konduk, T.; Celebi, A.] Kocaeli Univ, Div Gastroenterol, Fac Med, TR-41380 Kocaeli, Turkey.
   [Sahin, T.] Kocaeli Univ, Fac Med, Dept Cardiol, TR-41380 Kocaeli, Turkey.
C3 Kocaeli University; Kocaeli University
RP Kocaman, O (corresponding author), Kocaeli Univ, Div Gastroenterol, Fac Med, TR-41380 Kocaeli, Turkey.
EM drokocaman@hotmail.com
RI Şahin, Tuğçe/G-2962-2018; Konduk, Buğra/AAH-1079-2020
OI KONDUK, BUGRA/0000-0002-9138-9984; KOCAMAN, ORHAN/0009-0005-7866-3626;
   Senturk, Omer/0000-0003-2342-9136
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NR 38
TC 37
Z9 41
U1 0
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1444-0903
EI 1445-5994
J9 INTERN MED J
JI Intern. Med. J.
PD MAR
PY 2008
VL 38
IS 3
BP 183
EP 189
DI 10.1111/j.1445-5994.2007.01481.x
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 263ZK
UT WOS:000253254800007
PM 17725609
DA 2025-06-11
ER

PT J
AU Redline, S
   Storfer-Isser, A
   Rosen, CL
   Johnson, NL
   Kirchner, HL
   Emancipator, J
   Kibler, AM
AF Redline, Susan
   Storfer-Isser, Amy
   Rosen, Carol L.
   Johnson, Nathan L.
   Kirchner, H. Lester
   Emancipator, Judith
   Kibler, Anna Marie
TI Association between metabolic syndrome and sleep-disordered breathing in
   adolescents
SO AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
LA English
DT Article
DE sleep apnea; metabolic syndrome; obesity
ID POSITIVE AIRWAY PRESSURE; 3RD NATIONAL-HEALTH; NUTRITION EXAMINATION
   SURVEY; INSULIN-RESISTANCE; FOLLOW-UP; GLUCOSE-TOLERANCE;
   DIABETES-MELLITUS; PUBERTAL CHANGES; RISK-FACTORS; CHILDREN
AB Rationale: Metabolic syndrome (MetS) affects 4 to 10% of adolescents. Risk factors include overweight, male sex, and Hispanic ethnicity. Although sleep-disordered breathing (SDB) has been implicated as a risk factor for MetS in adults, its association with SDB in adolescents is unknown.
   Objectives: To define the association of SDB with MetS in adolescents.
   Methods: Standardized measurements of SDB, anthropometry and bioassays, were made in 270 adolescents, aged 13.6 +/- 0.7 years. MetS was identified if threshold levels were exceeded in three of five areas: waist circumference, blood pressure, triglyceride level, high-density lipoprotein cholesterol level, and glucose levels.
   Measurements and Main Results: Although 70% of children with SDB (apnea-hypopnea index >= 5) were overweight and 59% had MetS, 16% of children without SDB had MetS. Twenty-five percent of those with MetS had SDB. After adjusting for age, race, sex, and preterm status, children with SDB had a 6.49 (95% confidence interval, 2.52, 16.70) increased odds of MetS compared with children without SDB. Indices of SDB stress associated with MetS included respiratory event frequency, degree of oxygen desaturation, and sleep efficiency. Analyses of individual metabolic parameters showed that, after adjustment for body mass index, SDB was associated with systolic and diastolic blood pressure, low-density lipoprotein cholesterol, and fasting insulin levels.
   Conclusions: A majority of adolescents with SDB are overweight and meet criteria for MetS. The close association between MetS and SDB and their putative interacting pathophysiologies suggests a need to develop screening, prevention, and treatment strategies for both disorders in high-risk, overweight adolescents.
C1 Case Western Reserve Univ, Rainbow Babies & Childrens Hosp, Dept Pediat, Cleveland, OH 44106 USA.
   Case Western Reserve Univ, Dept Epidemiol & Biostat, Cleveland, OH 44106 USA.
C3 University Hospitals of Cleveland; Rainbow Babies & Children's Hospital;
   University System of Ohio; Case Western Reserve University; Case Western
   Reserve University Hospital; University System of Ohio; Case Western
   Reserve University
RP Redline, S (corresponding author), Case Western Reserve Univ, Rainbow Babies & Childrens Hosp, Dept Pediat, 11100 Euclid Ave, Cleveland, OH 44106 USA.
EM susan.redline@case.edu
FU NCI NIH HHS [1 U54CA116867] Funding Source: Medline; NCRR NIH HHS [M01
   RR00080] Funding Source: Medline; NHLBI NIH HHS [HL07567, HL60957, K23
   HL04426] Funding Source: Medline; NINR NIH HHS [R01 NR02707] Funding
   Source: Medline
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NR 57
TC 213
Z9 228
U1 0
U2 5
PU AMER THORACIC SOC
PI NEW YORK
PA 25 BROADWAY, 18 FL, NEW YORK, NY 10004 USA
SN 1073-449X
EI 1535-4970
J9 AM J RESP CRIT CARE
JI Am. J. Respir. Crit. Care Med.
PD AUG 15
PY 2007
VL 176
IS 4
BP 401
EP 408
DI 10.1164/rccm.200703-375OC
PG 8
WC Critical Care Medicine; Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Respiratory System
GA 199FR
UT WOS:000248682100015
PM 17541017
OA Green Published
DA 2025-06-11
ER

PT J
AU Adams-Huet, B
   Jialal, I
AF Adams-Huet, Beverley
   Jialal, Ishwarlal
TI An Increasing Triglyceride-Glucose Index Is Associated with a
   Pro-Inflammatory and Pro-Oxidant Phenotype
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Article
DE insulin resistance; triglyceride-glucose index; inflammation; metabolic
   syndrome
ID INSULIN-RESISTANCE; METABOLIC SYNDROME; ADIPOSE-TISSUE; SURROGATE;
   CHEMERIN; PRODUCT; DISEASE
AB Background/Objectives: Insulin resistance is crucial in the pathogenesis of Metabolic Syndrome (MetS), type 2 diabetes mellitus (T2DM) and premature atherosclerotic cardiovascular disease (ASCVD). The triglyceride-glucose index (TyG index), a validated measure of insulin resistance, also predicts MetS, T2DM, the severity of albuminuria and ASCVD. There are scant data providing mechanistic insights into these sequalae. Accordingly, we investigated the relationship between the TyG index and biomarkers of inflammation, oxidative stress, free fatty acid (FFA) levels and adipokine dysregulation in a cohort comprising both controls and patients with nascent MetS. Methods: Participants (n = 102) included 59 patients with MetS and 43 controls. People with diabetes, ASCVD, smoking and macro-inflammation were excluded. Fasting blood was obtained for both plasma and monocyte isolation. Results: Receiver Operating Characteristic (ROC) curve analysis revealed that the TyG index was an excellent predictor of MetS with an area under the curve of 0.87, and it correlated with both hepatic and adipose tissue insulin resistance. Both serum RBP-4 levels and non-HDL cholesterol increased significantly over tertiles of the TyG index. Based on the TyG index tertiles and/or correlations, oxidized LDL, nitrotyrosine, C-reactive protein, endotoxin, chemerin, interleukin-6 levels and monocyte toll-like receptor (TLR)-4 and TLR-2 and their cellular signaling were significantly associated with the TyG index. Conclusions: Increased non-HDL-C and, most importantly, a pro-inflammatory and pro-oxidant state could be advanced as potential mechanisms explaining the increased risk for T2DM and ASCVD with an increasing TyG index.
C1 [Adams-Huet, Beverley] UT Southwestern Med Ctr, Dallas, TX 75235 USA.
   [Jialal, Ishwarlal] Univ Calif Davis, Sch Med, 2616 Hepworth Dr, Davis, CA 95618 USA.
C3 University of Texas System; University of Texas Southwestern Medical
   Center Dallas; University of California System; University of California
   Davis
RP Jialal, I (corresponding author), Univ Calif Davis, Sch Med, 2616 Hepworth Dr, Davis, CA 95618 USA.
EM huet@digitrain.com; kjialal@gmail.com
OI jialal, kenny/0000-0001-9113-2604
FX We thank the volunteers for participating in our study.
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NR 36
TC 8
Z9 8
U1 0
U2 0
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD JUL
PY 2024
VL 13
IS 13
AR 3941
DI 10.3390/jcm13133941
PG 9
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA YO0V8
UT WOS:001269319900001
PM 38999506
OA Green Submitted, gold, Green Published
DA 2025-06-11
ER

PT J
AU Li, PF
   Lin, YJ
   Liang, YJ
   Chen, WL
AF Li, Peng-Fei
   Lin, Yu-Jen
   Liang, Yao-Jen
   Chen, Wei-Liang
TI The Association between Human Epididymis Secretory Protein 4 and
   Metabolic Syndrome
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Article
DE human epididymis protein 4; 2 metabolic syndrome components; 3
   carcinogenesis
ID OVARIAN MALIGNANCY ALGORITHM; OXIDATIVE STRESS; SERUM HE-4; CANCER;
   RISK; INFLAMMATION; BIOMARKER; DISEASE; CA125; WOMEN
AB Individuals with metabolic syndrome (MetS) are known to have an increased risk of carcinogenesis. Human epididymis protein 4 (HE4) is a tumor marker and prognostic factor for epithelial ovarian carcinoma (EOC) patients. However, no studies have evaluated the association between MetS and HE4 levels. This study aimed to evaluate the relationship between HE4 levels and MetS in the National Health and Nutrition Examination Survey (NHANES 2001-2002). This cross-sectional analysis assessed all five components of MetS and HE4 levels in 2104 females (age >= 20 years) from the NHANES dataset. MetS was defined according to the National Cholesterol Education Program Adult Treatment Panel III (NCEP ATPIII) criteria. The analysis indicated MetS in 593 individuals, and the beta coefficient of their HE4 levels was 0.097 (95% CIs, 0.028-0.166, p = 0.006). Specifically, the beta coefficients of the HE4 levels of participants with 1, 2, 3, and >= 4 features of MetS were 0.072 (95% confidence interval (CI): -0.015-0.159), 0.125 (95% CI: 0.030-0.220), 0.161 (95% CI: 0.053-0.270), and 0.242 (95% CI: 0.117-0.368), respectively, and all p values were p-value for the trend was <0.001. There was a significant association between the presence of MetS and HE4 levels. There were positive relationships between HE4 levels and an increased number of MetS components (with 1, 2, 3, and >= 4 features of MetS, all p values <0.001). Among the MetS components, low high-density lipoprotein levels and high triglyceride levels were independently associated with HE4 levels.
C1 [Li, Peng-Fei] Triserv Gen Hosp, Natl Def Med Sch, Div Endocrinol & Metab, Dept Internal Med, Taipei 114, Taiwan.
   [Li, Peng-Fei] Fu Jen Catholic Univ, Grad Inst Appl Sci & Engn, New Taipei 242, Taiwan.
   [Lin, Yu-Jen; Chen, Wei-Liang] Triserv Gen Hosp, Div Family Med, Dept Family & Community Med, Taipei 114, Taiwan.
   [Lin, Yu-Jen; Chen, Wei-Liang] Natl Def Med Ctr, Sch Med, Taipei 114, Taiwan.
   [Liang, Yao-Jen] Fu Jen Catholic Univ, Grad Inst Appl Sci & Engn, New Taipei 242, Taiwan.
   [Liang, Yao-Jen] Fu Jen Catholic Univ, Dept & Inst Life Sci, New Taipei 242, Taiwan.
   [Chen, Wei-Liang] Triserv Gen Hosp, Div Geriatr Med, Dept Family & Community Med, Taipei 114, Taiwan.
   [Chen, Wei-Liang] Natl Def Med Ctr, Dept Biochem, Taipei 114, Taiwan.
C3 National Defense Medical Center; Tri-Service General Hospital; Fu Jen
   Catholic University; Tri-Service General Hospital; National Defense
   Medical Center; Fu Jen Catholic University; Fu Jen Catholic University;
   Tri-Service General Hospital; National Defense Medical Center
RP Chen, WL (corresponding author), Triserv Gen Hosp, Div Family Med, Dept Family & Community Med, Taipei 114, Taiwan.; Chen, WL (corresponding author), Natl Def Med Ctr, Sch Med, Taipei 114, Taiwan.; Chen, WL (corresponding author), Triserv Gen Hosp, Div Geriatr Med, Dept Family & Community Med, Taipei 114, Taiwan.; Chen, WL (corresponding author), Natl Def Med Ctr, Dept Biochem, Taipei 114, Taiwan.
EM milkfly198383@gmail.com; ronyowei@yahoo.com.tw; yjl@mail.fju.edu.tw;
   weiliang0508@gmail.com
RI Li, Jenny/GSD-3780-2022; Li, Pengfei/AFW-1229-2022
OI Li, Peng-Fei/0000-0002-3044-7976; LIN, YU JEN/0000-0001-5720-0458; Chen,
   Wei-liang/0000-0003-0784-230X
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NR 43
TC 1
Z9 1
U1 0
U2 3
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD MAY
PY 2022
VL 11
IS 9
AR 2362
DI 10.3390/jcm11092362
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 1G8PX
UT WOS:000796113000001
PM 35566488
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Al Akl, NS
   Khalifa, O
   Errafii, K
   Arredouani, A
AF Al Akl, Neyla S.
   Khalifa, Olfa
   Errafii, Khaoula
   Arredouani, Abdelilah
TI Association of dyslipidemia, diabetes and metabolic syndrome with serum
   ferritin levels: a middle eastern population-based cross-sectional study
SO SCIENTIFIC REPORTS
LA English
DT Article
ID INSULIN-RESISTANCE; OXIDATIVE STRESS; IRON; RISK; GLUCOSE; HEALTH
AB Elevated serum ferritin (SFer) levels are implicated in many energy metabolism abnormalities. The association between SFer levels and metabolic disorders has not been studied in Middle Eastern populations. We aimed at exploring the association between SFer levels and serum lipids, diabetes determinants, and metabolic syndrome in a sample of Qatari adults. This study used biochemical parameters obtained from 1928 participants from the Qatar Biobank cohort. We utilized adjusted multivariable logistic regression analysis to estimate the odds ratios (ORs) for dyslipidemia, type 2 diabetes, the homeostasis model assessment of insulin resistance (HOMA-IR), and metabolic syndrome (MetS) according to sex-specific SFer quartiles (Q1 to Q4). Results revealed that the ORs for dyslipidemia increased progressively and significantly across the SFer quartiles, up to two folds in Q4 for women (OR 2.47 (1.68-3.62)) and men (OR 2.24 (1.41-3.55)) versus Q1 (OR:1). Exclusively in women, the ORs for IR (HOMA-IR > 3.58) increased significantly in Q4 (OR 1.79 (1.19-2.70)) versus OR 1 in Q1 as did the ORs for diabetes (OR: 2.03 (1.15-3.57) in Q4 versus OR 1 in Q1). We observed the same result when we pooled the participants with prediabetes and diabetes in one group. The OR for MetS also increased significantly across the Sfer Quartiles from OR: 1 in Q1 to 1.92 (1.06-3.02) in Q4 for women and to 2.07 (1.08-3.98) in Q4 in men. Our results suggest the elevated Sfer levels as a potential risk biomarker for dyslipidemia and MetS in adult Qatari men and women, and diabetes and IR in women only.
C1 [Al Akl, Neyla S.; Khalifa, Olfa; Errafii, Khaoula; Arredouani, Abdelilah] Hamad Bin Khalifa Univ HBKU, Qatar Fdn, Diabet Res Ctr, Qatar Biomed Res Inst QBRI, Doha, Qatar.
   [Errafii, Khaoula; Arredouani, Abdelilah] Hamad Bin Khalifa Univ HBKU, Qatar Fdn, Coll Hlth & Life Sci, Doha, Qatar.
C3 Qatar Foundation (QF); Hamad Bin Khalifa University-Qatar; Qatar
   Biomedical Research Institute (QBRI); Qatar Foundation (QF); Hamad Bin
   Khalifa University-Qatar
RP Arredouani, A (corresponding author), Hamad Bin Khalifa Univ HBKU, Qatar Fdn, Diabet Res Ctr, Qatar Biomed Res Inst QBRI, Doha, Qatar.; Arredouani, A (corresponding author), Hamad Bin Khalifa Univ HBKU, Qatar Fdn, Coll Hlth & Life Sci, Doha, Qatar.
EM aarredouani@hbku.edu.qa
RI arredouani, abdelilah/Q-9650-2019
OI Errafii, Khaoula/0000-0003-4744-2431
FU intermural grant from Qatar Biomedical Research Institute
FX The project was funded by intermural grant from Qatar Biomedical
   Research Institute to AA.
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NR 40
TC 14
Z9 14
U1 0
U2 5
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD DEC 16
PY 2021
VL 11
IS 1
AR 24080
DI 10.1038/s41598-021-03534-y
PG 9
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA XP8GQ
UT WOS:000731098600004
PM 34916585
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Machin, PA
   Tsonou, E
   Hornigold, DC
   Welch, HCE
AF Machin, Polly A.
   Tsonou, Elpida
   Hornigold, David C.
   Welch, Heidi C. E.
TI Rho Family GTPases and Rho GEFs in Glucose Homeostasis
SO CELLS
LA English
DT Review
DE Rho GTPase; small G protein; Rho GEF; guanine nucleotide exchange
   factor; glucose homeostasis; metabolic syndrome; type 2 diabetes; GLUT4
   glucose transporter; insulin-stimulated glucose uptake;
   glucose-stimulated insulin secretion
ID GUANINE-NUCLEOTIDE-EXCHANGE; ACTIVATED PROTEIN-KINASE; STIMULATED GLUT4
   TRANSLOCATION; CYCLIN D1 EXPRESSION; ACTIN STRESS FIBERS;
   SKELETAL-MUSCLE; INSULIN-RESISTANCE; P21-ACTIVATED KINASE; SIGNALING
   PATHWAY; RAC-ACTIVATION
AB Dysregulation of glucose homeostasis leading to metabolic syndrome and type 2 diabetes is the cause of an increasing world health crisis. New intriguing roles have emerged for Rho family GTPases and their Rho guanine nucleotide exchange factor (GEF) activators in the regulation of glucose homeostasis. This review summates the current knowledge, focusing in particular on the roles of Rho GEFs in the processes of glucose-stimulated insulin secretion by pancreatic beta cells and insulin-stimulated glucose uptake into skeletal muscle and adipose tissues. We discuss the ten Rho GEFs that are known so far to regulate glucose homeostasis, nine of which are in mammals, and one is in yeast. Among the mammalian Rho GEFs, P-Rex1, Vav2, Vav3, Tiam1, Kalirin and Plekhg4 were shown to mediate the insulin-stimulated translocation of the glucose transporter GLUT4 to the plasma membrane and/or insulin-stimulated glucose uptake in skeletal muscle or adipose tissue. The Rho GEFs P-Rex1, Vav2, Tiam1 and beta-PIX were found to control the glucose-stimulated release of insulin by pancreatic beta cells. In vivo studies demonstrated the involvement of the Rho GEFs P-Rex2, Vav2, Vav3 and PDZ-RhoGEF in glucose tolerance and/or insulin sensitivity, with deletion of these GEFs either contributing to the development of metabolic syndrome or protecting from it. This research is in its infancy. Considering that over 80 Rho GEFs exist, it is likely that future research will identify more roles for Rho GEFs in glucose homeostasis.
C1 [Machin, Polly A.; Tsonou, Elpida; Welch, Heidi C. E.] Babraham Inst, Signalling Programme, Babraham Res Campus, Cambridge CB22 3AT, England.
   [Tsonou, Elpida; Hornigold, David C.] AstraZeneca, BioPharmaceut R&D, Biosci Metab Res & Early Dev Cardiovasc Renal & M, Cambridge CB22 3AT, England.
C3 UK Research & Innovation (UKRI); Biotechnology and Biological Sciences
   Research Council (BBSRC); Babraham Institute; AstraZeneca
RP Welch, HCE (corresponding author), Babraham Inst, Signalling Programme, Babraham Res Campus, Cambridge CB22 3AT, England.
EM polly.machin@babraham.ac.uk; elpida.tsonou1@astrazeneca.com;
   David.Hornigold@astrazeneca.com; heidi.welch@babraham.ac.uk
RI Tsonou, Elpida/NGS-6849-2025
OI Machin, Polly/0000-0002-8481-8488
FU Institute Strategic Programme Grant from the BBSRC [BB/P013384/1];
   BBSRC; AstraZeneca-MedImmune
FX This research was funded by Institute Strategic Programme Grant
   BB/P013384/1 from the BBSRC to the Signalling Programme at the Babraham
   Institute. P.A.M. receives a targeted studentship from the BBSRC. E.T.
   received an iCASE studentship from the BBSRC in collaboration with
   AstraZeneca-MedImmune.
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NR 197
TC 24
Z9 26
U1 0
U2 13
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2073-4409
J9 CELLS-BASEL
JI Cells
PD APR
PY 2021
VL 10
IS 4
AR 915
DI 10.3390/cells10040915
PG 27
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA RR1SB
UT WOS:000642885400001
PM 33923452
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Cheraghi, Z
   Mirmiran, P
   Mansournia, MA
   Moslehi, N
   Khalili, D
   Nedjat, S
AF Cheraghi, Zahra
   Mirmiran, Parvin
   Mansournia, Mohammad Ali
   Moslehi, Nazanin
   Khalili, Davood
   Nedjat, Saharnaz
TI The association between nutritional exposures and metabolic syndrome in
   the Tehran Lipid and Glucose Study (TLGS): a cohort study
SO PUBLIC HEALTH
LA English
DT Article
DE Metabolic syndrome (MetS); Nutritional exposures; Tehran lipid and
   glucose study; Prospective study
ID FAST-FOOD CONSUMPTION; 3RD NATIONAL-HEALTH; C-REACTIVE PROTEIN;
   BODY-MASS INDEX; RISK-FACTORS; WAIST CIRCUMFERENCE; OXIDATIVE STRESS;
   ADULT-POPULATION; RICE INTAKE; PREVALENCE
AB Objectives: This study was conducted with the goal of investigating the effect of various food consumption on the incidence of metabolic syndrome (MetS).
   Study design: Prospective cohort study.
   Methods: This study conducted on 3616 healthy adults aged >= 20 years, who were not affected with MetS. Nutritional intake was determined at the beginning of the study (2008-2011) by the Food Frequency Questionnaire (FFQ), and the incidence of MetS was investigated after a median of 24.6 months follow-up. Data were analyzed by multiple logistic regression, with 95% confidence interval.
   Results: After adjusting the effect of other variables in the model many foods in the whole grains group - such as Sangak bread (OR = 0.35, 95% CI: 0.11-1.56), multiple types of vegetables and fruits such as peach (OR = 0.11, 95% CI: 0.01-0.75), and mushroom (OR = 0.28, 95% CI: 0.11-0.71) had protective effects against MetS. From the dairy group yoghurt (OR = 0.43, 95% CI: 0.18-1.01) and ice cream (OR = 0.35, 95% CI: 0.12-1.06) had similar such effects.
   Conclusion: Based on our findings, there was a significant rise in the incidence of MetS in Iran. The daily consumption of foods from the whole grains, dairy, vegetable and fruit groups can help reduce the odds of MetS. (C) 2016 The Royal Society for Public Health. Published by Elsevier Ltd. All rights reserved.
C1 [Cheraghi, Zahra; Mansournia, Mohammad Ali] Univ Tehran Med Sci, Dept Epidemiol & Biostat, Sch Publ Hlth, Tehran, Iran.
   [Mirmiran, Parvin; Moslehi, Nazanin] Shahid Beheshti Univ Med Sci, Nutr & Endocrine Res Ctr, Res Inst Endocrine Sci, Tehran, Iran.
   [Mirmiran, Parvin] Shahid Beheshti Univ Med Sci, Dept Clin Nutr & Dietet, Fac Nutr Sci & Food Technol, Natl Nutr & Food Technol Res Inst, Tehran, Iran.
   [Khalili, Davood] Shahid Beheshti Univ Med Sci, Prevent Metab Disorders Res Ctr, Res Inst Endocrine Sci, Tehran, Iran.
   [Khalili, Davood] Shahid Beheshti Univ Med Sci, Sch Publ Hlth, Dept Epidemiol, Tehran, Iran.
   [Nedjat, Saharnaz] Univ Tehran Med Sci, Sch Publ Hlth, Dept Epidemiol & Biostat, Knowledge Utilizat Res Ctr, Tehran, Iran.
C3 Tehran University of Medical Sciences; Shahid Beheshti University
   Medical Sciences; Shahid Beheshti University Medical Sciences; Shahid
   Beheshti University Medical Sciences; Shahid Beheshti University Medical
   Sciences; Tehran University of Medical Sciences
RP Mirmiran, P (corresponding author), Shahid Beheshti Univ Med Sci, Dept Clin Nutr & Dietet, Fac Nutr Sci & Food Technol, Natl Nutr & Food Technol Res Inst, Tehran, Iran.; Nedjat, S (corresponding author), Univ Tehran Med Sci, Sch Publ Hlth, Dept Epidemiol & Biostat, Knowledge Utilizat Res Ctr, Tehran, Iran.
EM cheraghiz@ymail.com; mirmiran@endocrine.ac.ir; mansournia_ma@yahoo.com;
   moslehinazanin@yahoo.com; dkhalili@endocrine.ac.ir; nejatsan@tums.ac.ir
RI Cheraghi, Zahra/AAF-6877-2019; Moslehi, Nazanin/R-8154-2019; mansournia,
   Mohammad/AFA-8899-2022; Mirmiran, Parvin/V-1433-2019; Khalili,
   Davood/T-2913-2017; Cheraghi, Zahra/H-6376-2013
OI Khalili, Davood/0000-0003-4956-1039; Cheraghi,
   Zahra/0000-0001-9041-559X; Cheraghi, Zahra/0000-0001-6076-4916;
   Mansournia, Mohammad Ali/0000-0003-3343-2718; Mirmiran,
   Parvin/0000-0003-2391-4924; Moslehi, Nazanin/0000-0001-8441-5200
FU Tehran University of Medical Sciences (TUMS) [912-112-8002]
FX This article is one of the first author's Ph.D. thesis (Thesis code:
   912-112-8002) and supported by Tehran University of Medical Sciences
   (TUMS).
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NR 60
TC 14
Z9 15
U1 1
U2 4
PU W B SAUNDERS CO LTD
PI LONDON
PA 32 JAMESTOWN RD, LONDON NW1 7BY, ENGLAND
SN 0033-3506
EI 1476-5616
J9 PUBLIC HEALTH
JI Public Health
PD NOV
PY 2016
VL 140
BP 163
EP 171
DI 10.1016/j.puhe.2016.07.003
PG 9
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA EE2FD
UT WOS:000389398200026
PM 27498945
DA 2025-06-11
ER

PT J
AU Ersoy, K
   Anaforoglu, I
   Algün, E
AF Ersoy, Kerem
   Anaforoglu, Inan
   Algun, Ekrem
TI Serum ischemic modified albumin levels might not be a marker of
   oxidative stress in patients with hypothyroidism
SO ENDOCRINE
LA English
DT Article
DE Hypothyroidism; Subclinical hypothyroidism; Ischemic modified albumin;
   Ischemia
ID BINDING; ASSAY
AB Overt hypothyroidism and subclinical hypothyroidism are thought to be associated with atherosclerosis and a chronic ischemic process. Ischemic modified albumin (IMA) is a novel marker of ischemia. We examined serum IMA levels in patients with subclinical and overt hypothyroidism. We recruited patients who presented to our clinic for thyroid disease control. We compared demographic data, fasting blood sugar, serum lipid levels, and the prevalence of metabolic syndrome by the presence of overt, subclinical, and no hypothyroidism. Cobalt binding to albumin capacity was analyzed using a rapid colorimetric technique and compared among the groups. We assessed 11 men and 74 women with a mean age of 39.9 +/- 12 years. Of these, 48 (56.5 %) were euthyroid, 24 (28.2 %) had subclinical hypothyroidism, and 13 (15.3 %) had overt hypothyroidism. The groups did not differ significantly in terms of age; body mass index; waist circumference; systolic and diastolic blood pressures; levels of fasting and nonfasting blood sugar, high- and low-density lipoproteins, and triglycerides; and the presence of metabolic syndrome. Mean serum IMA level also did not differ significantly among the groups: 0.20 +/- 0.08 absorbance units (ABSU) in the euthyroid participants, 0.18 +/- 0.08 ABSU in those with subclinical hypothyroidism, and 0.20 +/- 0.09 ABSU in those with overt hypothyroidism (P = 0.754). Mean IMA values did not differ significantly by sex, cigarette use, the presence of metabolic syndrome, or the presence of thyroid autoantibodies. Serum IMA levels did not differ among patients with overt or subclinical hypothyroidism in this case-control study.
C1 [Ersoy, Kerem; Algun, Ekrem] Trabzon Numune Egitim & Arastirma Hastanesi, Dept Endocrinol, TR-61000 Trabzon, Turkey.
   [Anaforoglu, Inan] Trabzon Numune Egitim & Arastirma Hastanesi, Endokrinol Klin, TR-61000 Trabzon, Turkey.
C3 Trabzon Kanuni Training & Research Hospital; Trabzon Kanuni Training &
   Research Hospital
RP Anaforoglu, I (corresponding author), Trabzon Numune Egitim & Arastirma Hastanesi, Endokrinol Klin, TR-61000 Trabzon, Turkey.
EM ianaforoglu@hotmail.com
RI ANAFOROĞLU, İNAN/AAG-8413-2021
FU Sanofi-Aventis (Istanbul, Turkey)
FX English language editing of this manuscript was performed by Patricia
   French of Left Lane Communications (Chapel Hill, NC, USA) and funded by
   Sanofi-Aventis (Istanbul, Turkey).
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NR 22
TC 10
Z9 10
U1 0
U2 9
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1355-008X
EI 1559-0100
J9 ENDOCRINE
JI Endocrine
PD APR
PY 2013
VL 43
IS 2
BP 430
EP 433
DI 10.1007/s12020-012-9796-7
PG 4
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 106CX
UT WOS:000316120300027
PM 23001626
DA 2025-06-11
ER

PT J
AU Jang, SJ
   Chu, CM
   Yang, TY
   Lin, YS
   Tsai, MF
   Chang, ST
AF Jang, Shih-Jung
   Chu, Chi-Ming
   Yang, Teng-Yao
   Lin, Yu-Sheng
   Tsai, Ming-Feng
   Chang, Shih-Tai
TI Coronary Artery Phenotypes in Subjects With Negative Myocardial
   Perfusion Imaging and Typical Angina Pectoris
SO AMERICAN JOURNAL OF THE MEDICAL SCIENCES
LA English
DT Article
DE Myocardial perfusion scintigraphy; Coronary artery disease; Metabolic
   syndrome; Obesity
ID PROGNOSTIC VALUE; DIAGNOSTIC-ACCURACY; SEGMENTAL ANALYSIS; STRESS TEST;
   FOLLOW-UP; TL-201; SCINTIGRAPHY; DISEASE; PREDICTORS; EXTENT
AB Introduction: Limited data are available on coronary lesion morphology for patients with false-negative radionuclide findings together with typical angina symptoms. Methods: The study group consisted of 25 subjects with a negative pharmacological thallium (Tl)-201 single-photon emission computed tomography perfusion imaging study but typical angina symptoms and coronary artery disease (CAD) confirmed by coronary angiography. The control group included 690 subjects with a positive pharmacological Tl-201 single-photon emission computed tomography study and CAD. Results: The study group showed a significantly older and higher female ratio than the control group. Significant differences were found between the 2 groups in the presence of current smoking status and hypertension. A noticeably higher percentage of positive metabolic syndrome ratio, number of metabolic syndrome components, high waist-to-hip ratio percentage and high waist circumference percentage in the study group. The study group was noticeably lower in mean numbers of culprit vessel involvement and mean lesion numbers than the control group. There were more individuals with type A classification and a lower proportion of complex stenoses-which contain type B2 and C lesions-in the study group than in the control group. The study group had significantly fewer calcified stenoses and complex morphology stenoses-the latter of which include lesion morphologies with chronic total occlusion, diffuse and calcification-than the control group. Conclusions: For the high probability of CAD lesions that requires interventional therapy, patients with negative myocardial scintigraphy but typical angina symptoms would be beneficial to intensive medical treatment and coronary study.
C1 [Jang, Shih-Jung; Yang, Teng-Yao; Lin, Yu-Sheng; Chang, Shih-Tai] Chiayi Chang Gung Mem Hosp, Div Cardiol, Pu Tz City, Chai Yi Hsien, Taiwan.
   [Tsai, Ming-Feng] Chiayi Chang Gung Mem Hosp, Div Nucl Med, Pu Tz City, Chai Yi Hsien, Taiwan.
   [Jang, Shih-Jung; Yang, Teng-Yao; Lin, Yu-Sheng; Chang, Shih-Tai] Chiayi Sch, Chang Gung Inst Technol, Chiayi Hsien, Taiwan.
   [Jang, Shih-Jung; Yang, Teng-Yao; Lin, Yu-Sheng; Chang, Shih-Tai] Chang Gung Univ, Coll Med, Tao Yuan, Taiwan.
   [Chu, Chi-Ming] Natl Def Med Ctr & Univ, Inst Publ Hlth, Sect Hlth Informat, Taipei, Taiwan.
C3 Chang Gung Memorial Hospital; Chang Gung Memorial Hospital; Chang Gung
   University of Science & Technology; Chang Gung University; National
   Defense Medical Center
RP Chang, ST (corresponding author), Chiayi Chang Gung Mem Hosp, Div Cardiol, 6 Sec W Chai Pu Rd, Pu Tz City, Chai Yi Hsien, Taiwan.
EM cst1234567@yahoo.com.tw
RI Chu, Christopher/HHN-4195-2022
OI Chu, Cordia/0000-0002-3683-5638
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NR 24
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0002-9629
EI 1538-2990
J9 AM J MED SCI
JI Am. J. Med. Sci.
PD NOV
PY 2010
VL 340
IS 5
BP 350
EP 355
DI 10.1097/MAJ.0b013e3181ee2f4e
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 675CI
UT WOS:000283802300002
PM 20724904
DA 2025-06-11
ER

PT J
AU Tsou, MT
   Chen, JY
AF Tsou, Meng-Ting
   Chen, Jau-Yuan
TI Burnout and metabolic syndrome among healthcare workers: Is subclinical
   hypothyroidism a mediator?
SO JOURNAL OF OCCUPATIONAL HEALTH
LA English
DT Article
DE burnout; healthcare workers; metabolic syndrome; Taiwan
ID SHIFT WORK; STRESS; RISK; ASSOCIATION; DISEASE
AB Objectives Evidence suggests that subclinical hypothyroidism (SCH) is associated with burnout and metabolic syndrome (MetS). We examined the relationship between burnout and MetS among healthcare workers (HCWs) and investigated the potential mediation of SCH. Methods This cross-sectional study included HCWs from a tertiary medical center; demographic data were obtained using a questionnaire. Burnout was evaluated according to the Chinese version of the Maslach Burnout Inventory-Health Services Survey (MBI-HSS). MetS and thyroid function data were obtained from a physical check-up. Logistic regression models were used to evaluate the adjusted odds ratio (aOR), and mediation analysis was employed to examine the mediation effect. Results Among 945 non-doctor/nurse and 1868 doctor/nurse staff, MetS was 30% and 14%, respectively, and the prevalence of burnout was nearly 6.5%. The results showed that burnout induced higher aOR of MetS in the doctor/nurse group (1.27, 95% confidence interval [CI]: 1.05-3.62). Thyroid-stimulating hormone (TSH) showed a positive association factor of MetS in doctor/nurse group-adjusted burnout (aOR = 1.15, 95% CI: 1.01-4.19). A higher TSH level was associated with an increased odds of MetS in younger doctor/nurse staff with burnout syndrome (aOR = 1.74; 95% CI: 1.04-3.22). There was a borderline significant mediation effect of SCH in the association between burnout and MetS in doctor/nurse staff. Conclusions The results showed that higher TSH levels were positively associated with burnout and MetS in doctor/nurse professionals, especially in the young cohort. Burnout may rely on the borderline mediation effect of SCH, which is likely to affect MetS.
C1 [Tsou, Meng-Ting] MacKay Mem Hosp, Dept Family Med, Taipei, Taiwan.
   [Tsou, Meng-Ting] MacKay Mem Hosp, Dept Occupat Med, Taipei, Taiwan.
   [Tsou, Meng-Ting] Dept MacKay Jr Coll Med Nursing & Management, New Taipei, Taiwan.
   [Chen, Jau-Yuan] Chang Gung Mem Hosp, Linkou Branch, Dept Family Med, 5 Fuxing St, Taoyuan 333, Taiwan.
   [Chen, Jau-Yuan] Chang Gung Univ, Coll Med, Taoyuan, Taiwan.
C3 Mackay Memorial Hospital; Mackay Memorial Hospital; Chang Gung Memorial
   Hospital; Chang Gung University
RP Chen, JY (corresponding author), Chang Gung Mem Hosp, Linkou Branch, Dept Family Med, 5 Fuxing St, Taoyuan 333, Taiwan.
EM welins@cgmh.org.tw
RI Chen, Hsing-yu/C-3979-2011
CR [Anonymous], 2018, ILOSH105M309 ILOSH105M309, V6
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NR 37
TC 4
Z9 4
U1 0
U2 9
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1341-9145
EI 1348-9585
J9 J OCCUP HEALTH
JI J. Occup. Health
PD JAN
PY 2021
VL 63
IS 1
AR e12252
DI 10.1002/1348-9585.12252
PG 10
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA TK7ZS
UT WOS:000674374000001
PM 34286911
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Morel, S
   Delvin, E
   Marcil, V
   Levy, E
AF Morel, Sophia
   Delvin, Edgard
   Marcil, Valerie
   Levy, Emile
TI Intestinal Dysbiosis and Development of Cardiometabolic Disorders in
   Childhood Cancer Survivors: A Critical Review
SO ANTIOXIDANTS & REDOX SIGNALING
LA English
DT Review
DE cancer survivors; metabolic syndrome; gut microbiota; dysbiosis;
   oxidative stress; inflammation
ID ACUTE LYMPHOBLASTIC-LEUKEMIA; LONG-TERM SURVIVORS; CARDIOVASCULAR
   RISK-FACTORS; YOUNG-ADULT SURVIVORS; HEMATOPOIETIC-CELL TRANSPLANTATION;
   IMPAIRED GLUCOSE-TOLERANCE; GROWTH-HORMONE DEFICIENCY; METABOLIC
   SYNDROME; INSULIN-RESISTANCE; GUT MICROBIOTA
AB Significance: Survivors of pediatric cancers have a high risk of developing side effects after the end of their treatments. Many potential factors have been associated with the onset of cardiometabolic disorders (CMD), including cancer disease itself, chemotherapy, hormonal treatment, radiotherapy, and genetics. However, the precise etiology and underlying mechanisms of these long-term complications are poorly understood.
   Recent Advances: Greater awareness is currently paid to the role of microbiota in the emergence of cancers and modulation of cancer therapies in both children and adults. Alterations in the composition and diversity of intestinal microbiota can clearly influence tumor development and progression as well as immune responses and clinical output. As dysbiosis is closely linked to the development of host metabolic diseases, including obesity, metabolic syndrome, type 2 diabetes, and non-alcoholic fatty liver disease, it may increase the risk of CMD in cancer populations.
   Critical Issues: Only limited studies targeting the profile of intestinal dysbiosis before and after cancer treatment have been conducted. Further, the exact contribution of intestinal dysbiosis to the development of CMD in cancer survivors is poorly appreciated. This review intends to clarify the influence of gut microbiota on CMD in childhood cancer survivors, elucidate the potential mechanisms, and evaluate the latest research on the interplay between diet/food supplement, microbiota, and cancer-related CMD.
   Future Directions: The implication of intestinal dysbiosis in late metabolic complications of childhood cancer survivors should be clarified. Intervention strategies could be developed to reduce the risk of survivors to CMD.
C1 [Morel, Sophia; Delvin, Edgard; Marcil, Valerie; Levy, Emile] Univ Montreal, St Justine Univ Hosp Hlth Ctr, Res Ctr, Montreal, PQ, Canada.
   [Morel, Sophia; Marcil, Valerie; Levy, Emile] Univ Montreal, Dept Nutr, Montreal, PQ, Canada.
   [Levy, Emile] Univ Montreal, Dept Pediat, Montreal, PQ, Canada.
C3 Universite de Montreal; Universite de Montreal; Universite de Montreal
RP Levy, E (corresponding author), CHU St Justine, Res Ctr, 3175 Cote Ste Catherine, Montreal, PQ H3T 1C5, Canada.
EM emile.levy@recherche-ste-justine.qc.ca
FU Institute of Cancer Research of the Canadian Institutes of Health
   Research; JA deSeve Research Chair in nutrition; FRSQ doctoral
   scholarship award; Cole Foundation Fellowship
FX This work was supported by a grant from the Institute of Cancer Research
   of the Canadian Institutes of Health Research (V.M. and E.L.), the JA
   deSeve Research Chair in nutrition (E.L.), the FRSQ doctoral scholarship
   award, and Cole Foundation Fellowship (S.M.).
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NR 199
TC 7
Z9 8
U1 0
U2 14
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1523-0864
EI 1557-7716
J9 ANTIOXID REDOX SIGN
JI Antioxid. Redox Signal.
PD JAN 20
PY 2021
VL 34
IS 3
BP 223
EP 251
DI 10.1089/ars.2020.8102
EA JUN 2020
PG 29
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA PP0DR
UT WOS:000538177700001
PM 32390455
DA 2025-06-11
ER

PT J
AU Park, JM
   Lee, JY
   Lee, DC
   Lee, YJ
AF Park, Jae-Min
   Lee, Jee-Yon
   Lee, Duk-Chul
   Lee, Yong-Jae
TI Serum -glutamyltransferase level and metabolic syndrome in children and
   adolescents: Korean National Health and Nutrition Examination Survey
SO JOURNAL OF DIABETES INVESTIGATION
LA English
DT Article
DE -Glutamyltransferase; Childhood obesity; Metabolic syndrome
ID TYPE-2 DIABETES-MELLITUS; GAMMA-GLUTAMYL-TRANSPEPTIDASE; FATTY
   LIVER-DISEASE; INSULIN-RESISTANCE; CARDIOVASCULAR-DISEASE; TRANSFERASE
   LEVELS; OXIDATIVE STRESS; RISK; MEN; WOMEN
AB Aims/IntroductionSerum -glutamyltransferase (GGT) is positively related to cardiometabolic diseases, such as type 2 diabetes mellitus, hypertension and metabolic syndrome (MetS), in adult populations. Our aim was to investigate whether serum GGT is independently associated with MetS and its components in a nationally representative sample of Korean children and adolescents.
   Materials and MethodsThe study included data from 1,618 participants (867 boys, 751 girls) aged 10-18years from the 2010-2011 Korean National Health and Nutrition Examination Survey. MetS was diagnosed by the 2007 International Diabetes Federation criteria for children and adolescents. Participants were stratified using a cut-off value of the 75th percentile of serum GGT levels (19IU/L for boys, 15IU/L for girls). The odds ratios and 95% confidence intervals for MetS and its components were determined with multiple logistic regression analyses.
   ResultsThe mean values of most cardiometabolic variables were significantly higher in the upper stratum. Except for low high-density lipoprotein cholesterol in boys and elevated blood pressure in girls, participants in the upper GGT stratum had significantly higher odds of MetS and its components than those in the lower stratum. The multivariate-adjusted odds ratios for MetS for the upper stratum were 5.79 (95% confidence interval 1.21-27.02) in boys and 6.20 (95% confidence interval 1.71-22.47) in girls, after adjusting for age, household income and residential area.
   ConclusionsSerum GGT was positively associated with MetS and its components in Korean children and adolescents. Serum GGT could be a useful measure for identifying children and adolescents with MetS.
C1 [Park, Jae-Min] Konkuk Univ, Dept Family Med, Seoul, South Korea.
   [Lee, Jee-Yon] CHA Univ, CHA Bundang Med Ctr, Coll Med, Chaum Life Ctr,Dept Family Med, Seoul, South Korea.
   [Lee, Duk-Chul; Lee, Yong-Jae] Yonsei Univ, Coll Med, Dept Family Med, Seoul, South Korea.
C3 Konkuk University; Konkuk University Medical Center; Pochon Cha
   University; Yonsei University; Yonsei University Health System
RP Lee, YJ (corresponding author), Yonsei Univ, Coll Med, Dept Family Med, Seoul, South Korea.
EM ukyjhome@yuhs.ac
RI Lee, Yong Jae/GLR-4153-2022; Lee, Jee-Yon/GER-4141-2022
OI Lee, Jee-Yon/0000-0002-6376-2681; Lee, Duk Chul/0000-0001-9166-1813;
   Lee, Yong-Jae/0000-0002-6697-476X; Park, JaeMin/0000-0001-8873-8832
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   [Anonymous], 2007 KOR CHILDR AD G
   [Anonymous], KOR NAT HLTH NUTR EX
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NR 38
TC 10
Z9 10
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2040-1124
J9 J DIABETES INVEST
JI J. Diabetes Investig.
PD MAY
PY 2018
VL 9
IS 3
BP 522
EP 528
DI 10.1111/jdi.12716
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA GF1ZE
UT WOS:000431734700011
PM 28741806
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Kaya, Z
   Caglayan, S
   Akkiprik, M
   Aral, C
   Ozisik, G
   Ozata, M
   Ozer, A
AF Kaya, Z.
   Caglayan, S.
   Akkiprik, M.
   Aral, C.
   Ozisik, G.
   Ozata, M.
   Ozer, A.
TI Impact of glucocorticoid receptor gene (NR3C1) polymorphisms in Turkish
   patients with metabolic syndrome
SO JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
LA English
DT Article
DE Metabolic syndrome; Glucocorticoid receptor gene; Glucocorticoid
ID C-REACTIVE PROTEIN; FRAGMENT-LENGTH-POLYMORPHISM; PITUITARY-ADRENAL
   AXIS; IN-VIVO; CHINESE POPULATION; ASSOCIATION; SENSITIVITY; STRESS;
   RISK; BCLI
AB Background The metabolic syndrome (MetS) is characterized by a cluster of metabolic factors, including insulin resistance and type-2 diabetes, abdominal obesity, dyslipidemia, hypertension and microalbuminuria. Impaired glucocorticoid receptor (GR) activity also plays an important role in the etiology of MetS. The objective of our study is to evaluate the effects of GR gene polymorphisms (BclI, N363S, TthIII1 and ER22/23EK) in Turkish patients with MetS.
   Materials and methods Seventy subjects with MetS and 185 healthy controls were enrolled in the study. PCR-RFLP analysis was used for genotyping. Results for each polymorphism have been verified by allele-specific oligonucleotide analysis.
   Results BclI GG genotype was significantly associated with an increased risk of MetS (p = 0.02). Also, only in women, the G allele carriers were significantly associated with higher C-peptide. T allele carriers of TthIII1 polymorphism were significantly associated with higher C-peptide, triglyceride, insulin and C-reactive protein (CRP, p value 0.048, 0.022, 0.005 and 0.022, respectively), and lower fasting blood glucose (FBG, p = 0.02). The combined carriers of BclI polymorphism G allele and TthIII1 polymorphism T allele were significantly associated with higher diastolic blood pressure in all patients, and lower FBG and postprandial blood glucose in only men. All the ER22/23EK polymorphisms coexisted with polymorphic variant of TthIII1 (p = 0.0058).
   Conclusion The presence of homozygote polymorphic variant of BclI might be good predictive markers for the disease susceptibility. The BclI and the TthIII1 polymorphism are associated with sex-specific clinical parameters. Our findings also suggest that the combination of BclI and TthIII1 polymorphisms may play a protective role in blood glucose.
C1 [Kaya, Z.; Akkiprik, M.; Ozer, A.] Marmara Univ, Sch Med, Dept Med Biol, Basibuyuk Mah,Maltepe Basibuyuk Yolu Sok 9-1, TR-34854 Istanbul, Turkey.
   [Kaya, Z.] Yuzuncu Yil Univ, Sch Med, Dept Med Biol, Van, Turkey.
   [Caglayan, S.] Istanbul Medipol Univ, Sch Med, Dept Internal Med, Div Endocrinol & Metab, Istanbul, Turkey.
   [Aral, C.] Namik Kemal Univ, Fac Arts & Sci, Dept Mol Biol, Tekirdag, Turkey.
   [Ozisik, G.] Zorlu Ctr, Mem Wellness Endocrinol & Metab, Istanbul, Turkey.
   [Ozata, M.] Parc 15 Endocrinol & Metab Clin, Istanbul, Turkey.
C3 Marmara University; Yuzuncu Yil University; Istanbul Medipol University;
   Namik Kemal University
RP Ozer, A (corresponding author), Marmara Univ, Sch Med, Dept Med Biol, Basibuyuk Mah,Maltepe Basibuyuk Yolu Sok 9-1, TR-34854 Istanbul, Turkey.
EM aozer@marmara.edu.tr
RI Akkiprik, Mustafa/AAD-6167-2020; Kaya, Zehra/AAE-8135-2020; Akkiprik,
   Mustafa/A-6453-2017
OI Akkiprik, Mustafa/0000-0002-1100-765X; Aral, Cenk/0000-0002-6044-1372;
   Kaya, Zehra/0000-0001-6222-7882
FU Scientific and Technological Research Council of Turkey (TUBITAK)
   [104S272, SBAG-K-60]; Research Foundation of Marmara University (BAPKO)
   [SAG-C-DRP-101011-0286]
FX The authors appreciate Dr. Can Erzik for his critical revision of the
   manuscript. This work was partly supported by a grant (104S272,
   SBAG-K-60 to SC) from the Scientific and Technological Research Council
   of Turkey (TUBITAK) and grants (SAG-C-DRP-101011-0286 to AO) from the
   Research Foundation of Marmara University (BAPKO).
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NR 35
TC 14
Z9 15
U1 0
U2 20
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1720-8386
J9 J ENDOCRINOL INVEST
JI J. Endocrinol. Invest.
PD MAY
PY 2016
VL 39
IS 5
BP 557
EP 566
DI 10.1007/s40618-015-0409-1
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA DJ3KB
UT WOS:000374102700010
PM 26596278
DA 2025-06-11
ER

PT J
AU Polhemus, DJ
   Bradley, JM
   Islam, KN
   Brewster, LP
   Calvert, JW
   Tao, YX
   Chang, CC
   Pipinos, II
   Goodchild, TT
   Lefer, DJ
AF Polhemus, David J.
   Bradley, Jessica M.
   Islam, Kazi N.
   Brewster, Luke P.
   Calvert, John W.
   Tao, Ya-Xiong
   Chang, Carlos C.
   Pipinos, Iraklis I.
   Goodchild, Traci T.
   Lefer, David J.
TI Therapeutic potential of sustained-release sodium nitrite for critical
   limb ischemia in the setting of metabolic syndrome
SO AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
LA English
DT Article
DE nitric oxide; metabolic syndrome; angiogenesis; peripheral arterial
   disease; Ossabaw swine; endothelial nitric oxide synthase; nitrite
ID PERIPHERAL ARTERIAL-DISEASE; CORONARY-HEART-DISEASE; OXIDE SYNTHASE;
   ENDOTHELIAL DYSFUNCTION; HINDLIMB ISCHEMIA; BLOOD-FLOW; ANGIOGENESIS;
   MODEL; PREVALENCE; SAFETY
AB Nitrite is a storage reservoir of nitric oxide that is readily reduced to nitric oxide under pathological conditions. Previous studies have demonstrated that nitrite levels are significantly reduced in cardiovascular disease states, including peripheral vascular disease. We investigated the cytoprotective and proangiogenic actions of a novel, sustained-release formulation of nitrite (SR-nitrite) in a clinically relevant in vivo swine model of critical limb ischemia (CLI) involving central obesity and metabolic syndrome. CLI was induced in obese Ossabaw swine (n = 18) by unilateral external iliac artery deployment of a full cross-sectional vessel occlusion device positioned within an endovascular expanded polytetrafluoroethylene-lined nitinol stent-graft. At post-CLI day 14, pigs were randomized to placebo (n = 9) or SR-nitrite (80 mg, n = 9) twice daily by mouth for 21 days. SR-nitrite therapy increased nitrite, nitrate, and S-nitrosothiol in plasma and ischemic skeletal muscle. Oxidative stress was reduced in ischemic limb tissue of SR-nitrite- compared with placebo-treated pigs. Ischemic limb tissue levels of proangiogenic growth factors were increased following SR-nitrite therapy compared with placebo. Despite the increases in cytoprotective and angiogenic signals with SR-nitrite therapy, new arterial vessel formation and enhancement of blood flow to the ischemic limb were not different from placebo. Our data clearly demonstrate cytoprotective and proangiogenic signaling in ischemic tissues following SR-nitrite therapy in a very severe model of CLI. Further studies evaluating longer-duration nitrite therapy and/or additional nitrite dosing strategies are warranted to more fully evaluate the therapeutic potential of nitrite therapy in peripheral vascular disease.
C1 [Polhemus, David J.; Bradley, Jessica M.; Islam, Kazi N.; Goodchild, Traci T.; Lefer, David J.] LSU Hlth Sci Ctr, Cardiovasc Ctr Excellence, New Orleans, LA 70112 USA.
   [Polhemus, David J.; Bradley, Jessica M.; Islam, Kazi N.; Goodchild, Traci T.; Lefer, David J.] LSU Hlth Sci Ctr, Dept Pharmacol, New Orleans, LA 70112 USA.
   [Brewster, Luke P.; Calvert, John W.] Emory Univ, Sch Med, Dept Surg, Atlanta, GA 30322 USA.
   [Brewster, Luke P.] Atlanta Vet Affairs Med Ctr, Surg & Res Serv, Decatur, GA USA.
   [Brewster, Luke P.] Georgia Inst Technol, Parker H Petit Inst Bioengn & Biosci, Atlanta, GA 30332 USA.
   [Tao, Ya-Xiong] Auburn Univ, Coll Vet Med, Dept Anat Physiol & Pharmacol, Auburn, AL 36849 USA.
   [Chang, Carlos C.] Emory Univ, Labs T3, Atlanta, GA 30322 USA.
   [Pipinos, Iraklis I.] Univ Nebraska, Med Ctr, Dept Cellular & Integrat Physiol, Omaha, NE USA.
C3 Louisiana State University System; Louisiana State University Health
   Sciences Center New Orleans; Louisiana State University System;
   Louisiana State University Health Sciences Center New Orleans; Emory
   University; US Department of Veterans Affairs; Veterans Health
   Administration (VHA); Atlanta VA Health Care System; University System
   of Georgia; Georgia Institute of Technology; Auburn University System;
   Auburn University; Emory University; University of Nebraska System;
   University of Nebraska Medical Center
RP Lefer, DJ (corresponding author), LSU Hlth Sci Ctr, Cardiovasc Ctr Excellence, 533 Bolivar St,Suite 408, New Orleans, LA 70112 USA.
EM dlefe1@lsuhsc.edu
RI Lefer, David/A-6372-2012; Tao, Ya-Xiong/K-4939-2019; Calvert,
   John/F-4497-2014
OI Tao, Ya-Xiong/0000-0003-4737-749X; Pipinos, Iraklis/0000-0001-6873-6346;
   Lefer, David/0000-0003-2293-7278; Calvert, John/0000-0001-6858-6042
FU National Heart, Lung, and Blood Institute [1R01 HL-092141, 1R01
   HL-093579, 1U24 HL-094373, 1P20 HL-113452, 1K08 HL-119592]; National
   Center for Advancing Translational Sciences Clinical and Translational
   Science Award Program [UL1 TR-000454]; American Heart Association Grant
   [13IRG14740001]; Carlyle Fraser Heart Center at Emory University Midtown
   Hospital; Emory University Department of Surgery; LSU Medical School
   Alumni Association; American Heart Association (AHA) [13IRG14740001]
   Funding Source: American Heart Association (AHA)
FX This work was supported by National Heart, Lung, and Blood Institute
   Grants 1R01 HL-092141, 1R01 HL-093579, 1U24 HL-094373, and 1P20
   HL-113452 (to D. J. Lefer) and 1K08 HL-119592 (to L. P. Brewster) and in
   part by National Center for Advancing Translational Sciences Clinical
   and Translational Science Award Program Grant UL1 TR-000454 (to L. P.
   Brewster) and American Heart Association Grant 13IRG14740001 (to L. P.
   Brewster). Generous funding was provided by the Carlyle Fraser Heart
   Center at Emory University Midtown Hospital, the Emory University
   Department of Surgery, and the LSU Medical School Alumni Association.
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NR 45
TC 16
Z9 17
U1 0
U2 4
PU AMER PHYSIOLOGICAL SOC
PI Rockville
PA 6120 Executive Blvd, Suite 600, Rockville, MD, UNITED STATES
SN 0363-6135
EI 1522-1539
J9 AM J PHYSIOL-HEART C
JI Am. J. Physiol.-Heart Circul. Physiol.
PD JUL 1
PY 2015
VL 309
IS 1
BP H82
EP H92
DI 10.1152/ajpheart.00115.2015
PG 11
WC Cardiac & Cardiovascular Systems; Physiology; Peripheral Vascular
   Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Physiology
GA CM2IG
UT WOS:000357502700008
PM 25910804
OA Green Published
DA 2025-06-11
ER

PT J
AU Lee, MJ
   Jung, CH
   Kang, YM
   Hwang, JY
   Jang, JE
   Leem, J
   Park, JY
   Kim, HK
   Lee, WJ
AF Lee, M. J.
   Jung, C. H.
   Kang, Y. M.
   Hwang, J. Y.
   Jang, J. E.
   Leem, J.
   Park, J. -Y.
   Kim, H. -K.
   Lee, W. J.
TI Serum bilirubin as a predictor of incident metabolic syndrome: A 4-year
   retrospective longitudinal study of 6205 initially healthy Korean men
SO DIABETES & METABOLISM
LA English
DT Article
DE Bilirubin; Metabolic syndrome; Antioxidant
ID CARDIOVASCULAR-DISEASE; ANTIOXIDANT; ADULTS; RISK
AB Aim. - Serum bilirubin is an endogenous antioxidant with anti-inflammatory properties. Several cross-sectional studies have reported that bilirubin was negatively associated with oxidative stress-mediated diseases, including the metabolic syndrome (MetS). However, the clinical relevance of bilirubin as a risk factor for incident MetS remains controversial. For this reason, the longitudinal effects of baseline serum bilirubin concentrations on incident MetS were evaluated in Korean men.
   Methods. This 4-year retrospective longitudinal observational study involved 6205 Korean men without MetS. Subjects underwent routine health examinations in 2007 and returned for a follow-up examination in 2011. Baseline serum bilirubin concentrations were determined using the vanadate oxidation method.
   Results. During the 4-year period, 936 cases of incident MetS (15.1%) were identified. Its incidence decreased across baseline bilirubin quartile categories (P<0.001), with an odds ratio (OR) for developing MetS being significantly lower in the highest quartile group (>= 1.40 mg/dL) compared with the lowest (<= 0.90 mg/dL) after adjusting for all confounding variables [OR = 0.70,95% confidence interval (CI) 0.54-0.90; P for trend = 0.019]. Among individual components of MetS, bilirubin was found to be negatively associated with only the risk of incident hypertriglyceridaemia. The OR (95% CI) for incident hypertriglyceridaemia in the highest vs lowest quartile was 0.75 (0.61-0.91; P for trend = 0.002).
   Conclusion. Serum total bilirubin level was negatively associated with incidence of MetS in healthy Korean men over a 4-year period. (C) 2014 Elsevier Masson SAS. All rights reserved.
C1 [Lee, M. J.; Jung, C. H.; Kang, Y. M.; Jang, J. E.; Leem, J.; Park, J. -Y.; Lee, W. J.] Univ Ulsan Coll Med, Dept Internal Med, Asan Med Ctr, Seoul, South Korea.
   [Hwang, J. Y.; Kim, H. -K.] Univ Ulsan Coll Med, Dept Hlth Screening & Promot Ctr, Asan Med Ctr, Seoul, South Korea.
C3 University of Ulsan; Asan Medical Center; University of Ulsan; Asan
   Medical Center
RP Lee, WJ (corresponding author), Univ Ulsan Coll Med, Dept Internal Med, Asan Med Ctr, Seoul, South Korea.
EM lwjatlas@naver.com
RI Jung, Chang/AAU-7897-2020; Leem, Jaechan/AAQ-6648-2020; Kang,
   Yu/AAW-2935-2020; Jeong, Young-Hoon/F-3476-2015
OI Jung, Chang Hee/0000-0003-4043-2396; Leem, Jaechan/0000-0003-2329-4374
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NR 15
TC 40
Z9 41
U1 0
U2 14
PU MASSON EDITEUR
PI MOULINEAUX CEDEX 9
PA 21 STREET CAMILLE DESMOULINS, ISSY, 92789 MOULINEAUX CEDEX 9, FRANCE
SN 1262-3636
EI 1878-1780
J9 DIABETES METAB
JI Diabetes Metab.
PD SEP
PY 2014
VL 40
IS 4
BP 305
EP 309
DI 10.1016/j.diabet.2014.04.006
PG 5
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA AQ8MB
UT WOS:000343078500010
PM 24951082
DA 2025-06-11
ER

PT J
AU Lind, L
   Wohlin, M
   Andren, B
   Sundström, J
AF Lind, Lars
   Wohlin, Martin
   Andren, Bertil
   Sundstrom, Johan
TI The echogenicity of the intimamedia complex in the common carotid artery
   is related to insulin resistance measured by the hyperinsulinemic clamp
   in elderly men
SO CLINICAL PHYSIOLOGY AND FUNCTIONAL IMAGING
LA English
DT Article
DE carotid artery; insulin resistance; metabolic syndrome; obesity;
   ultrasound
ID INDEPENDENT PREDICTOR; METABOLIC SYNDROME; MEDIA THICKNESS;
   MYOCARDIAL-INFARCTION; OXIDATIVE STRESS; RISK; ULTRASOUND; MORTALITY;
   ECHOGENECITY; INFLAMMATION
AB The echogenicity of the intimamedia complex (IM-GSM) has recently been shown to be related to the echogenicity in carotid artery plaque and to predict cardiovascular (CV) mortality. The present study aims to evaluate the relationship between metabolic CV risk factors, with special emphasis on insulin resistance, and IM-GSM in the carotid artery. Carotid artery ultrasound with grey-scale median analysis of the intimamedia complex, IM-GSM, was performed in a population sample of 480 men aged 75years. In these subjects, a euglycemic hyperinsulinemic clamp to investigate insulin resistance was performed together with measurements of conventional CV risk factors at the age of 70. The metabolic syndrome (MetS) was defined by the NCEP/ATPIII-criteria. In univariate analysis, IM-GSM in the common carotid artery was inversely correlated with the intimamedia thickness (IMT), body mass index (BMI), waist/hip ratio, fasting glucose, serum triglycerides, low HDL cholesterol and insulin resistance at the clamp (r=0 center dot 24, P<0 center dot 001). In multiple regression analysis, only insulin resistance at the clamp and BMI were independently related to IM-GSM. Subjects with the MetS (22%) showed a reduced IM-GSM when compared to those without (64 +/- 20 SD versus 68 +/- 19, P<0 center dot 05). Because the echogenicity of the intimamedia complex in the carotid artery is related to obesity and insulin resistance at clamp independently of IMT, this new vascular characteristic would serve as a marker of vascular alterations induced by insulin resistance and the MetS and has the advantage to be obtainable in almost all subjects.
C1 [Lind, Lars; Sundstrom, Johan] Uppsala Univ, Dept Med, S-75185 Uppsala, Sweden.
   [Wohlin, Martin] Uppsala Univ, Dept Geriatr, S-75185 Uppsala, Sweden.
   [Andren, Bertil] Uppsala Univ, Dept Clin Physiol, S-75185 Uppsala, Sweden.
C3 Uppsala University; Uppsala University; Uppsala University
RP Lind, L (corresponding author), Uppsala Univ, Dept Med Sci, S-75185 Uppsala, Sweden.
EM lars.lind@medsci.uu.se
RI Lind, Lars/KAM-1968-2024; Sundström, Johan/IAP-6197-2023
OI Sundstrom, Johan/0000-0003-2247-8454
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NR 25
TC 11
Z9 13
U1 0
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1475-0961
EI 1475-097X
J9 CLIN PHYSIOL FUNCT I
JI Clin. Physiol. Funct. Imaging
PD MAR
PY 2013
VL 33
IS 2
BP 137
EP 142
DI 10.1111/cpf.12006
PG 6
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA 086BQ
UT WOS:000314658400008
PM 23383692
DA 2025-06-11
ER

PT J
AU Relf, BL
   Larkin, EK
   De Torres, C
   Baur, LA
   Christodoulou, J
   Waters, KA
AF Relf, Bronwyn L.
   Larkin, Emma K.
   De Torres, Carina
   Baur, Louise A.
   Christodoulou, John
   Waters, Karen A.
TI Genome-wide linkage of obstructive sleep apnoea and high-density
   lipoprotein cholesterol in a Filipino family: bivariate linkage analysis
   of obstructive sleep apnoea
SO JOURNAL OF SLEEP RESEARCH
LA English
DT Article
DE bivariate; gene; inflammation; metabolic syndrome; obesity; respiratory
   disturbance index
ID METABOLIC SYNDROME; INSULIN-RESISTANCE; SUSCEPTIBILITY LOCUS;
   AFRICAN-AMERICAN; RISK-FACTORS; T-CELLS; SCAN; ASSOCIATION;
   INFLAMMATION; CHILDREN
AB P>Increasing evidence supports an association between obstructive sleep apnoea (OSA) and metabolic syndrome (MeS) in both children and adults, suggesting a genetic component. However, the genetic relationship between the diseases remains unclear. We performed a bivariate linkage scan on a single Filipino family with a high prevalence of OSA and MeS to explore the genetic pathways underlying these diseases. A large rural family (n = 50, 50% adults) underwent a 10-cM genome-wide scan. Fasting blood was used to measure insulin, triglycerides, total cholesterol and high density lipoprotein (HDL) cholesterol. Attended overnight polysomnography was used to quantify the respiratory disturbance index (RDI), a measure of sleep apnoea. Body mass index z-scores and insulin resistance scores were calculated. Bivariate multipoint linkage analyses were performed on RDI and MeS components. OSA prevalence was 46% (n = 23; nine adults, 14 children) in our participants. MeS phenotype was present in 40% of adults (n = 10) and 48% of children (n = 12). Linkage peaks with a logarithm of odds (LOD) score > 3 were demonstrated on chromosome 19q13.4 (LOD = 3.04) for the trait pair RDI and HDL cholesterol. Candidate genes identified in this region include the killer cell immunoglobulin-like receptor genes. These genes are associated with modulating inflammatory responses in reaction to cellular stress and initiation of atherosclerotic plaque formation. We have identified a novel locus for genetic links between RDI and lipid factors associated with MeS in a chromosomal region containing genes associated with inflammatory responses.
C1 [Relf, Bronwyn L.; Baur, Louise A.; Christodoulou, John; Waters, Karen A.] Univ Sydney, Discipline Paediat & Child Hlth, Sydney, NSW 2006, Australia.
   [Larkin, Emma K.] Case Western Reserve Univ, Ctr Clin Invest, Cleveland, OH 44106 USA.
   [Christodoulou, John] Childrens Hosp Westmead, Western Sydney Genet Program, Sydney, NSW, Australia.
   [Waters, Karen A.] Childrens Hosp Westmead, Resp Support Serv, Sydney, NSW, Australia.
C3 University of Sydney; University System of Ohio; Case Western Reserve
   University; NSW Health; The Children's Hospital at Westmead; University
   of Sydney; University of Sydney; NSW Health; The Children's Hospital at
   Westmead
RP Waters, KA (corresponding author), Childrens Hosp, Dept Resp Med, Locked Bag 4001, Westmead, NSW 2145, Australia.
EM karenw2@chw.edu.au
RI Christodoulou, John/E-5866-2015; Waters, Karen/B-2840-2013; Baur,
   Louise/AAE-3413-2021; Christodoulou, John/M-3628-2019
OI Baur, Louise/0000-0002-4521-9482; Christodoulou,
   John/0000-0002-8431-0641; Waters, Karen/0000-0001-8699-2175
FU NHLBL [HL070784]; NHMRC [249403]; NIH [KL2-RR024990]; National Center
   for Research
FX We thank Rose White for performing the DNA extractions, and Sherryn
   Bailey for monitoring and scoring the sleep studies. Funding source:
   NHLBL HL070784 (K. A. W.), NHMRC 249403 (K. A. W.) and NIH: KL2-RR024990
   (E. K. L.). Some of the results of this paper were obtained by using the
   software package S. A. G. E., which is supported by a U. S. Public
   Health Service Resource Grant from the National Center for Research.
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NR 52
TC 11
Z9 12
U1 0
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0962-1105
EI 1365-2869
J9 J SLEEP RES
JI J. Sleep Res.
PD JUN
PY 2010
VL 19
IS 2
BP 349
EP 357
DI 10.1111/j.1365-2869.2009.00797.x
PG 9
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 597UB
UT WOS:000277786300012
PM 20149069
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Wu, YY
   Xu, GQ
   Bai, RX
   Yu, PP
   He, ZX
   Chen, MX
   Hu, YK
   Jiang, T
   Yang, YH
   Liu, DF
   Mei, Y
   Qi, XY
   Cheng, FF
AF Wu, Yuanyuan
   Xu, Guoqiong
   Bai, Ruixue
   Yu, Pingping
   He, Zhongxiang
   Chen, Mengxue
   Hu, Yukun
   Jiang, Tao
   Yang, Yuanhang
   Liu, Dongfang
   Mei, Ying
   Qi, Xiaoya
   Cheng, Feifei
TI Association Between Circulating Zinc Levels and Risk Factors of
   Metabolic Syndrome: Insights from a Bi-directional Mendelian
   Randomization Analysis and Cross-Sectional Study
SO BIOLOGICAL TRACE ELEMENT RESEARCH
LA English
DT Article
DE Zinc; Metabolic syndrome; Lipids; Obesity; Mendelian randomization
ID INSULIN-RESISTANCE; SERUM ZINC; OXIDATIVE STRESS; SUPPLEMENTATION; MEN;
   MICRONUTRIENT; INFLAMMATION; COMPONENTS; MAGNESIUM; PEOPLE
AB Previous studies on the relationship between zinc and metabolic syndrome (MetS) have yielded inconsistent results. This comprehensive study aimed to elaborately explore the impact of zinc on MetS risk factors. The bi-directional Mendelian randomization (MR) analyses were performed to estimate the causal relationship between zinc and MetS risk factors. Additionally, a retrospective cross-sectional study incorporated 4389 subjects to provide a broader perspective in conjunction with the MR analyses. In the MR analyses, genetically instrumented zinc was positively associated with five of the MetS components in Europeans, including BMI, FBG, HbA1c, TC, and LDL-c (beta (95%CI) = 0.023 (0.019-0.027), 0.019 (0.013-0.025), 0.041 (0.022-0.060), 0.027 (0.013-0.042), and 0.018 (0.010-0.026), respectively). In the cross-sectional study, higher concentration of zinc was strongly associated with increased BMI, LDL-c, and UA (beta (95%CI) = 0.040 (0.010-0.085), 0.026 (0.018-0.035), and 1.529 (0.614-2.445), respectively). Moreover, these unfavorable associations were more obvious in women compared to men, with a borderline significant interaction effect for BMI (P=0.051). Our study showed that higher blood concentration of zinc, an essential trace element, was associated with unfavorable changes of the component metabolic risk factors of MetS, especially with BMI and LDL-c. Notably, these associations seemed to be more pronounced in women rather than in men. Further studies are warranted to elucidate the role of zinc status in the underlying mechanisms of MetS.
C1 [Wu, Yuanyuan; Xu, Guoqiong; Bai, Ruixue; Yu, Pingping; He, Zhongxiang; Chen, Mengxue; Hu, Yukun; Jiang, Tao; Yang, Yuanhang; Mei, Ying; Qi, Xiaoya; Cheng, Feifei] Chongqing Med Univ, Affiliated Hosp 2, Hlth Management Ctr, Chongqing, Peoples R China.
   [Liu, Dongfang] Chongqing Med Univ, Affiliated Hosp 2, Dept Endocrinol & Metab, Chongqing, Peoples R China.
C3 Chongqing Medical University; Chongqing Medical University
RP Qi, XY; Cheng, FF (corresponding author), Chongqing Med Univ, Affiliated Hosp 2, Hlth Management Ctr, Chongqing, Peoples R China.
EM qixiaoya66@cqmu.edu.cn; feifeicheng@hospital.cqmu.edu.cn
RI JIANG, TAO/AAU-5948-2020
FU We would like to acknowledge participants involved in this study. We
   also appreciate the efforts of physicians and nurses in the Department
   of Health Management Center of the Second Affiliated Hospital of
   Chongqing Medical University.; Department of Health Management Center of
   the Second Affiliated Hospital of Chongqing Medical University
FX We would like to acknowledge participants involved in this study. We
   also appreciate the efforts of physicians and nurses in the Department
   of Health Management Center of the Second Affiliated Hospital of
   Chongqing Medical University.
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NR 54
TC 2
Z9 2
U1 0
U2 11
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0163-4984
EI 1559-0720
J9 BIOL TRACE ELEM RES
JI Biol. Trace Elem. Res.
PD JUL
PY 2024
VL 202
IS 7
BP 3051
EP 3061
DI 10.1007/s12011-023-03918-3
EA OCT 2023
PG 11
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA TU9Q5
UT WOS:001085337500001
PM 37857990
DA 2025-06-11
ER

PT J
AU Watson, MA
   Brar, H
   Gibbs, ET II
   Wong, HS
   Dighe, PA
   McKibben, B
   Riedmaier, S
   Siu, A
   Polakowski, JS
   Segreti, JA
   Liu, XQ
   Chung, SW
   Pliushchev, YM
   Gesmundo, N
   Wang, Z
   Vortherms, TA
   Brand, MD
AF Watson, Mark A.
   Brar, Harmanmeet
   Gibbs II, Edwin T.
   Wong, Hoi-Shan
   Dighe, Pratiksha A.
   McKibben, Bryan
   Riedmaier, Stephan
   Siu, Amy
   Polakowski, James S.
   Segreti, Jason A.
   Liu, Xiaoqin
   Chung, SeungWon
   Pliushchev, Y. Marina
   Gesmundo, Nathan
   Wang, Zhi
   Vortherms, Timothy A.
   Brand, Martin D.
TI Suppression of superoxide/hydrogen peroxide production at mitochondrial
   site IQ decreases fat accumulation, improves glucose tolerance and
   normalizes fasting insulin concentration in mice fed a high-fat diet
SO FREE RADICAL BIOLOGY AND MEDICINE
LA English
DT Article
DE Mitochondria; S1QEL; Complex I; Glucose tolerance; Insulin; Reactive
   oxygen species
ID HYDROGEN-PEROXIDE; METABOLIC SYNDROME; OXIDATIVE STRESS; LACTIC
   ACIDEMIA; RESISTANCE; EMISSION; FEATURES; H2O2; VIVO
AB We developed S1QEL1.719, a novel bioavailable S1QEL (suppressor of site IQ electron leak). S1QEL1.719 prevented superoxide/hydrogen peroxide production at site IQ of mitochondrial complex I in vitro. The free concentration giving half-maximal suppression (IC50) was 52 nM. Even at 50-fold higher concentrations S1QEL1.719 did not inhibit superoxide/hydrogen peroxide production from other sites. The IC50 for inhibition of complex I electron flow was 500-fold higher than the IC50 for suppression of superoxide/hydrogen peroxide production from site IQ. S1QEL1.719 was used to test the metabolic effects of suppressing superoxide/hydrogen peroxide production from site IQ in vivo. C57BL/6J male mice fed a high-fat chow for one, two or eight weeks had increased body fat, decreased glucose tolerance, and increased fasting insulin concentrations, classic symptoms of metabolic syndrome. Daily prophylactic or therapeutic oral treatment of high-fat-fed animals with S1QEL1.719 decreased fat accumulation, strongly protected against decreased glucose tolerance and prevented or reversed the increase in fasting insulin level. Free exposures in plasma and liver at Cmax were 1-4 fold the IC50 for suppression of superoxide/hydrogen peroxide production at site IQ and substantially below levels that inhibit electron flow through complex I. These results show that the production of superoxide/hydrogen peroxide from mitochondrial site IQ in vivo is necessary for the induction and maintenance of glucose intolerance caused by a high-fat diet in mice. They raise the possibility that oral administration of S1QELs may be beneficial in metabolic syndrome.
C1 [Watson, Mark A.; Brar, Harmanmeet; Gibbs II, Edwin T.; Wong, Hoi-Shan; Dighe, Pratiksha A.; Brand, Martin D.] Buck Inst Res Aging, 8001 Redwood Blvd, Novato, CA 94945 USA.
   [McKibben, Bryan; Riedmaier, Stephan; Siu, Amy; Polakowski, James S.; Segreti, Jason A.; Liu, Xiaoqin; Chung, SeungWon; Pliushchev, Y. Marina; Gesmundo, Nathan; Wang, Zhi; Vortherms, Timothy A.] AbbVie Inc, 1 North Waukegan Rd, N Chicago, IL 60064 USA.
C3 Buck Institute for Research on Aging; AbbVie
RP Brand, MD (corresponding author), Buck Inst Res Aging, 8001 Redwood Blvd, Novato, CA 94945 USA.
EM mwatson@buckinstitute.org; harrmanb@gmail.com; eddygibbs007@yahoo.com;
   helenwonghs@gmail.com; pashadighe@gmail.com; bryan.mckibben@abbvie.com;
   stephan.riedmaier@bms.com; amy.y.siu@gmail.com;
   james.polakoski@abbvie.com; jason.segreti@abbvie.com;
   xiaoquin.liu@abbvie.com; seungwon.chung@abbvie.com;
   marina.pliushchev@abbvie.com; nathan.gesmundo@abbvie.com;
   zhi.wang@abbvie.com; timothy.vortherms@abbvie.com;
   mbrand@buckinstitute.org
RI Brand, Martin/A-9423-2012; Liu, Xiaoqin/AAB-7509-2019
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NR 45
TC 6
Z9 6
U1 0
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0891-5849
EI 1873-4596
J9 FREE RADICAL BIO MED
JI Free Radic. Biol. Med.
PD AUG 1
PY 2023
VL 204
BP 276
EP 286
DI 10.1016/j.freeradbiomed.2023.05.022
EA MAY 2023
PG 11
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA K5FG9
UT WOS:001016690200001
PM 37217089
OA hybrid
DA 2025-06-11
ER

PT J
AU Ruz, M
   Carrasco, F
   Rojas, P
   Basfi-fer, K
   Hernández, MC
   Pérez, A
AF Ruz, Manuel
   Carrasco, Fernando
   Rojas, Pamela
   Basfi-fer, Karen
   Catalina Hernandez, Maria
   Perez, Alvaro
TI Nutritional Effects of Zinc on Metabolic Syndrome and Type 2 Diabetes:
   Mechanisms and Main Findings in Human Studies
SO BIOLOGICAL TRACE ELEMENT RESEARCH
LA English
DT Article
DE Zinc; Metabolic syndrome; Diabetes
ID POLYCYSTIC-OVARY-SYNDROME; INSULIN-RESISTANCE; GLYCEMIC CONTROL;
   DOUBLE-BLIND; SERUM ZINC; ALLIXIN COMPLEXES; OXIDATIVE STRESS;
   TNF-ALPHA; SUPPLEMENTATION; RISK
AB Zinc (Zn) plays crucial roles in mammalian metabolism. There is increasing interest about the potential beneficial effects of Zn on the prevention or treatment of non-communicable diseases. This review critically analyzes the information related to the role of Zn on the metabolic syndrome (MetS) as well as type 2 diabetes (T2D), and summarizes the biological basis of these potential effects of Zn. There are several mechanisms by which Zn may help to prevent the development or progression of MetS and T2D, respectively. Zn is involved in both insulin secretion and action in peripheral tissues. Specifically, Zn has insulin-mimetic properties that increase the activity of the insulin signaling pathway. Zn modulates long-chain polyunsaturated fatty acids levels through its action on the absorption of essential fatty acids in the intestine and its subsequent desaturation. Zn is also involved in both the assembly of chylomicrons and lipoproteins as well as their clearance, and thus, plays a role in lipolysis regulation. Finally, Zn has been found to play a role in redox metabolism, and in turn, on blood pressure. The evidence related to the association between Zn status and occurrence of MetS is inconsistent. Although there are several studies reporting an inverse relationship between Zn status or dietary Zn intake and MetS prevalence, others found a direct relationship between Zn status and MetS prevalence. Intervention studies also provide confusing information about this issue, making it hard to reach firm conclusions. Zn as part of the treatment for patients with T2D has been shown to have positive responses in terms of glucose control outcomes, but only among those with Zn deficiency.
C1 [Ruz, Manuel; Carrasco, Fernando; Rojas, Pamela; Basfi-fer, Karen; Catalina Hernandez, Maria; Perez, Alvaro] Univ Chile, Fac Med, Dept Nutr, Santiago 1027, Chile.
C3 Universidad de Chile
RP Ruz, M (corresponding author), Univ Chile, Fac Med, Dept Nutr, Santiago 1027, Chile.
EM mruz@med.uchile.cl
RI Rojas, Pamela/N-5500-2018; Hernández-Rodas, María/ABG-5275-2021; Perez,
   Alvaro/N-8244-2017
OI Perez, Alvaro/0000-0001-8812-3301; Hernandez Rodas, Maria
   Catalina/0000-0001-9516-4056; Rojas, Pamela/0000-0001-6629-357X;
   Basfi-fer, Karen/0000-0002-9824-0162; Carrasco,
   Fernando/0000-0003-1103-3791
FU National Fund for Development of Science and Technology (FONDECYT)
   [1160792]; National Commission for Research in Science and Technology
   (CONICYT)-Advanced Human Capital Formation Program, National Doctoral
   Fellowship 2016 [21160453]
FX This research was funded by the National Fund for Development of Science
   and Technology (FONDECYT), research project 1160792 and by the National
   Commission for Research in Science and Technology (CONICYT)-Advanced
   Human Capital Formation Program, National Doctoral Fellowship 2016, No.
   21160453 (to MCH).
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NR 100
TC 59
Z9 68
U1 2
U2 35
PU HUMANA PRESS INC
PI TOTOWA
PA 999 RIVERVIEW DRIVE SUITE 208, TOTOWA, NJ 07512 USA
SN 0163-4984
EI 1559-0720
J9 BIOL TRACE ELEM RES
JI Biol. Trace Elem. Res.
PD MAR
PY 2019
VL 188
IS 1
BP 177
EP 188
DI 10.1007/s12011-018-1611-8
PG 12
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA HL3JN
UT WOS:000458610600016
PM 30600497
DA 2025-06-11
ER

PT J
AU Moreno-Fernández, S
   Garcés-Rimón, M
   Vera, G
   Astier, J
   Landrier, JF
   Miguel, M
AF Moreno-Fernandez, Silvia
   Garces-Rimon, Marta
   Vera, Gema
   Astier, Julien
   Landrier, Jean Francois
   Miguel, Marta
TI High Fat/High Glucose Diet Induces Metabolic Syndrome in an Experimental
   Rat Model
SO NUTRIENTS
LA English
DT Article
DE metabolic syndrome; obesity; diet induced obesity; rat model; high
   glucose; high fructose
ID INDUCED INSULIN-RESISTANCE; HIGH-FRUCTOSE; EXPRESSION; MITOCHONDRIA;
   BIOCHEMISTRY; DYSFUNCTION; OVERWEIGHT; OBESITY
AB Metabolic syndrome (MetS) is defined as a constellation of many metabolic disorders such as hypertension, impaired glucose tolerance, dyslipidemia and obesity, being this last disorder a key factor in the etiology of the syndrome. The widespread of MetS in actual society, mainly in developed countries, is becoming an important health problem and is increasing the need to develop new treatments against this pathology is increasing fast. The main objective of the present study was to evaluate the MetS-associated alterations developed in a new glucose diet-induced-obesity (DIO) rodent model. These alterations were also compared to those alterations developed in a fructose-DIO rodent model. Wistar rats were divided into four groups: Control (C), High-fat (HF), High-fat/high-fructose (HFF) and High-fat/high-glucose (HFG). The animals were fed ad libitum for 20 weeks. At the end of the study, HFG animals showed lower expression of energy expenditure genes when compared to the other DIO groups. Oxidative stress biomarkers such as MDA and mitochondrial RT-qPCR analyses showed an increase of oxidative damage together with mitochondrial dysfunction in HFG group. This group also showed increased insulin and glucose plasma levels, though HFF animals showed the greatest increase on these parameters. All DIO groups showed increased plasma levels of triglycerides. Altogether, our results indicated a better impact of glucose than fructose, when combined with a high-fat diet, to induce most of the alterations associated with MetS in rats. In addition, our research facilitates a new animal model to evaluate future treatments for MetS.
C1 [Moreno-Fernandez, Silvia; Miguel, Marta] UAM, CSIC, Bioact Anal Alimentos, Inst Invest Ciencias Alimentac,CIAL, Madrid 28049, Spain.
   [Moreno-Fernandez, Silvia; Vera, Gema; Miguel, Marta] CSIC, Inst Invest Ciencias Alimentac CIAL, Unidad Asociada IDi, E-28049 Madrid, Spain.
   [Garces-Rimon, Marta] Univ Francisco Vitoria, Inst Invest Biosanitarias, Grp Invest Biotecnol Alimentaria, Madrid 28233, Spain.
   [Vera, Gema] Univ Rey Juan Carlos, Fac Ciencias Salud, Dept Ciencias Basicas, Madrid 28922, Spain.
   [Astier, Julien; Landrier, Jean Francois] Aix Marseille Univ, INSERM, INRA, NORT, F-13385 Marseille, France.
C3 Autonomous University of Madrid; Consejo Superior de Investigaciones
   Cientificas (CSIC); CSIC-UAM - Instituto de Investigacion en Ciencias de
   la Alimentacion (CIAL); Consejo Superior de Investigaciones Cientificas
   (CSIC); CSIC-UAM - Instituto de Investigacion en Ciencias de la
   Alimentacion (CIAL); Universidad Francisco de Vitoria; Universidad Rey
   Juan Carlos; Institut National de la Sante et de la Recherche Medicale
   (Inserm); Aix-Marseille Universite; INRAE
RP Miguel, M (corresponding author), UAM, CSIC, Bioact Anal Alimentos, Inst Invest Ciencias Alimentac,CIAL, Madrid 28049, Spain.; Miguel, M (corresponding author), CSIC, Inst Invest Ciencias Alimentac CIAL, Unidad Asociada IDi, E-28049 Madrid, Spain.
EM silvia.moreno@csic.es; marta.garces@ufv.es; gema.vera@urjc.es;
   julien.astier@univ-amu.fr; jean-francois.landrier@univ-amu.fr;
   marta.miguel@csic.es
RI Vera, Gema/AAB-1731-2019; Garces-Rimon, Marta/AAD-3050-2021; MIGUEL
   CASTRO, MARTA/F-6112-2011; Landrier, Jean-Francois/AAH-2757-2019
OI Moreno-Fernandez, Silvia/0000-0002-9316-6477; Garces-Rimon,
   Marta/0000-0002-3888-4150; MIGUEL CASTRO, MARTA/0000-0002-5525-1056;
   Landrier, Jean-Francois/0000-0002-8690-8014; Vera Pasamontes,
   Gema/0000-0002-1838-0975
FU Spanish Ministry of Economy, Industry and Competitiveness (MINECO)
   [AGL2012-32387, AGL2017-89213, CSIC-INTRAMURAL 201570I028,
   BES-2013-065684, EEBB-I-16-11349]
FX This work was supported by the Spanish Ministry of Economy, Industry and
   Competitiveness (MINECO) (under the projects AGL2012-32387,
   AGL2017-89213 and CSIC-INTRAMURAL 201570I028 and under the grant numbers
   BES-2013-065684 and EEBB-I-16-11349).
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NR 40
TC 156
Z9 164
U1 2
U2 24
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD OCT
PY 2018
VL 10
IS 10
AR 1502
DI 10.3390/nu10101502
PG 15
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA GY7UM
UT WOS:000448821300168
PM 30322196
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Park, B
   Lee, YJ
AF Park, Byoungjin
   Lee, Yong-Jae
TI Metabolic syndrome and its components as risk factors for prolonged
   corrected QT interval in apparently healthy Korean men and women
SO JOURNAL OF CLINICAL LIPIDOLOGY
LA English
DT Article
DE Metabolic syndrome; Insulin resistance; QTc interval; Arrhythmia
ID MYOCARDIAL-INFARCTION; CARDIOVASCULAR MORTALITY; DIABETES-MELLITUS;
   OXIDATIVE STRESS; ASSOCIATION; DISPERSION; INSULIN; DYSFUNCTION;
   POPULATION; DYNAMICS
AB BACKGROUND: Metabolic syndrome (MetS) is clinically important because of its association with increased risk of sudden cardiac death, as well as cardiovascular disease-related mortality. Data between MetS and prolonged corrected QT (QTc) intervals, a useful predictor of sudden cardiac death, are limited in apparently healthy adults.
   OBJECTIVE: This study determined the association between MetS and QTc interval in apparently healthy Korean men and women.
   METHODS: We examined the association between MetS and QTc interval in 2157 Korean adults (1317 men and 840 women) in a health examination program but excluded participants with a history of ischemic heart disease, stroke, cardiac arrhythmia, cancer, thyroid, respiratory, renal, hepatobiliary, or rheumatologic disease. The QTc interval was calculated using Bazett's formula (QTc = QT/root RR). Multivariate-adjusted mean QTc values by the number of MetS components were calculated after sex stratification and compared using analysis of covariance test.
   RESULTS: The overall prevalence of MetS was 30.5% in men and 19.8% in women. The QTc interval positively correlated with age, body mass index, blood pressure, fasting plasma glucose, triglycerides, and potassium level in both men and women and negatively correlated with calcium and potassium levels and smoking status in men. The multivariate-adjusted mean QTc value increased proportionally with increasing number of MetS components (P values < 0.001 for both men and women).
   CONCLUSION: We confirmed the arrhythmogenic potential of MetS in apparently healthy Korean men and women. These findings suggest that careful monitoring of electrocardiography is necessary to evaluate possible arrhythmic risk in individuals with MetS. (C) 2018 National Lipid Association. All rights reserved.
C1 [Park, Byoungjin; Lee, Yong-Jae] Yonsei Univ, Coll Med, Dept Family Med, Seoul, South Korea.
   [Park, Byoungjin] Yongin Severance Hosp, Dept Family Med, Yongin, Gyeonggi Do, South Korea.
   [Lee, Yong-Jae] Univ Nevada, Sch Community Hlth Sci, Dept Healthcare Adm & Policy, Las Vegas, NV 89154 USA.
C3 Yonsei University; Yonsei University Health System; Yonsei University;
   Yonsei University Health System; Nevada System of Higher Education
   (NSHE); University of Nevada Las Vegas
RP Lee, YJ (corresponding author), Yonsei Univ, Coll Med, Gangnam Severance Hosp, Dept Family Med, 211 Eonju Ro, Seoul 06273, South Korea.
EM ukyjhome@yuhs.ac
RI Lee, Yong Jae/GLR-4153-2022; Park, Byoungjin/AAV-1810-2020
OI Park, Byoungjin/0000-0003-1733-5301; Lee, Yong-Jae/0000-0002-6697-476X
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NR 31
TC 8
Z9 9
U1 0
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1933-2874
EI 1876-4789
J9 J CLIN LIPIDOL
JI J. Clin. Lipidol.
PD OCT
PY 2018
VL 12
IS 5
BP 1298
EP 1304
DI 10.1016/j.jacl.2018.07.004
PG 7
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA GX5UB
UT WOS:000447815400031
PM 30100158
DA 2025-06-11
ER

PT J
AU Lee, TY
   Martinez-Outschoorn, UE
   Schilder, RJ
   Kim, CH
   Richard, SD
   Rosenblum, NG
   Johnson, JM
AF Lee, Teresa Y.
   Martinez-Outschoorn, Ubaldo E.
   Schilder, Russell J.
   Kim, Christine H.
   Richard, Scott D.
   Rosenblum, Norman G.
   Johnson, Jennifer M.
TI Metformin as a Therapeutic Target in Endometrial Cancers
SO FRONTIERS IN ONCOLOGY
LA English
DT Review
DE tumor microenvironment; metabolism; metformin; endometrial cancer;
   reverse Warburg
ID ACTIVATED PROTEIN-KINASE; METABOLIC SYNDROME; BREAST-CANCER;
   DIABETES-MELLITUS; TUMOR-STROMA; MESENCHYMAL TRANSITION; REPURPOSING
   METFORMIN; CELL-PROLIFERATION; OXIDATIVE STRESS; LACTATE SHUTTLE
AB Endometrial cancer is the most common gynecologic malignancy in developed countries. Its increasing incidence is thought to be related in part to the rise of metabolic syndrome, which has been shown to be a risk factor for the development of hyperestrogenic and hyperinsulinemic states. This has consequently lead to an increase in other hormone-responsive cancers as well e.g., breast and ovarian cancer. The correlation between obesity, hyperglycemia, and endometrial cancer has highlighted the important role of metabolism in cancer establishment and persistence. Tumor-mediated reprogramming of the microenvironment and macroenvironment can range from induction of cytokines and growth factors to stimulation of surrounding stromal cells to produce energy-rich catabolites, fueling the growth, and survival of cancer cells. Such mechanisms raise the prospect of the metabolic microenvironment itself as a viable target for treatment of malignancies. Metformin is a biguanide drug that is a first-line treatment for type 2 diabetes that has beneficial effects on various markers of the metabolic syndrome. Many studies suggest that metformin shows potential as an adjuvant treatment for uterine and other cancers. Here, we review the evidence for metformin as a treatment for cancers of the endometrium. We discuss the available clinical data and the molecular mechanisms by which it may exert its effects, with a focus on how it may alter the tumor microenvironment. The pleiotropic effects of metformin on cellular energy production and usage as well as intercellular and hormone-based interactions make it a promising candidate for reprogramming of the cancer ecosystem. This, along with other treatments aimed at targeting tumor metabolic pathways, may lead to novel treatment strategies for endometrial cancer.
C1 [Lee, Teresa Y.; Martinez-Outschoorn, Ubaldo E.; Schilder, Russell J.; Johnson, Jennifer M.] Thomas Jefferson Univ, Dept Med Oncol, Philadelphia, PA 19107 USA.
   [Kim, Christine H.; Richard, Scott D.; Rosenblum, Norman G.] Thomas Jefferson Univ, Dept Obstet & Gynecol, Philadelphia, PA 19107 USA.
C3 Thomas Jefferson University; Thomas Jefferson University
RP Johnson, JM (corresponding author), Thomas Jefferson Univ, Dept Med Oncol, Philadelphia, PA 19107 USA.
EM jennifer.m.johnson@jefferson.edu
RI Martinet, Wim/I-7375-2015
OI Martinez-Outschoorn, Ubaldo/0000-0003-1483-4551; Lee,
   Teresa/0009-0008-6640-0011
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NR 137
TC 62
Z9 64
U1 1
U2 23
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2234-943X
J9 FRONT ONCOL
JI Front. Oncol.
PD AUG 28
PY 2018
VL 8
AR 341
DI 10.3389/fonc.2018.00341
PG 14
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA GR7HL
UT WOS:000442859600002
PM 30211120
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Kim, S
   Song, Y
   Lee, JE
   Jun, S
   Shin, S
   Wie, GA
   Cho, YH
   Joung, H
AF Kim, Subeen
   Song, YoonJu
   Lee, Jung Eun
   Jun, Shinyoung
   Shin, Sangah
   Wie, Gyung-Ah
   Cho, Yoon Hee
   Joung, Hyojee
TI Total Antioxidant Capacity from Dietary Supplement Decreases the
   Likelihood of Having Metabolic Syndrome in Korean Adults
SO NUTRIENTS
LA English
DT Article
DE dietary supplements; antioxidant vitamins; total antioxidant capacity;
   metabolic syndrome; Korean adults
ID NUTRITION EXAMINATION SURVEY; RANDOMIZED CONTROLLED-TRIAL; HEALTHY-YOUNG
   ADULTS; C-REACTIVE PROTEIN; SERUM VITAMIN-A; OXIDATIVE STRESS;
   NATIONAL-HEALTH; US ADULTS; BETA-CAROTENE; CENTRAL ADIPOSITY
AB This study was conducted to estimate antioxidant vitamin intake and total antioxidant capacity (TAC) from diet and dietary supplements and to examine their association with metabolic syndrome (MetS) in Korean adults. Out of 6308 adults 19 similar to 64 years old from the 2010 similar to 2011 Korea National Health and Nutrition Examination Survey, 1847 adults were classified as dietary supplement users and the other 4461 adults were classified as non-users. Antioxidant intake and TAC from diet and dietary supplements were estimated using dietary intake data and linked with the antioxidant and TAC database for common Korean foods. The prevalence of MetS was lower in dietary supplement users (odds ratio (OR) = 0.82; 95% confidence interval (CI), 0.68-0.98) than that in non-users. Among dietary supplement users, a lower prevalence of MetS was observed in the highest tertile for vitamin A (OR = 0.72; 95% CI, 0.53-0.99) and vitamin E (OR = 0.74; 95% CI, 0.55-0.99) intake than that in the lowest tertile among non-users. Subjects in the highest tertile of TAC among dietary supplement users showed a lower prevalence of MetS (OR = 0.72; 95% CI, 0.52-0.99) than non-users. The results imply that intake of vitamin A, vitamin E, and TAC from dietary supplements might have a protective effect on MetS among Korean adults.
C1 [Kim, Subeen; Joung, Hyojee] Seoul Natl Univ, Grad Sch Publ Hlth, Dept Publ Hlth, Seoul 08826, South Korea.
   [Song, YoonJu] Catholic Univ Korea, Sch Human Ecol, Food & Nutr, Bucheon 14662, South Korea.
   [Lee, Jung Eun] Seoul Natl Univ, Coll Human Ecol, Dept Food & Nutr, Seoul 08826, South Korea.
   [Jun, Shinyoung] Purdue Univ, Dept Nutr Sci, W Lafayette, IN 47907 USA.
   [Shin, Sangah] Chung Ang Univ, Dept Food & Nutr, Gyeonggi Do 17546, South Korea.
   [Wie, Gyung-Ah] Natl Canc Ctr, Res Inst & Hosp, Dept Clin Nutr, Goyang Si 10408, South Korea.
   [Cho, Yoon Hee] Univ Montana, Dept Biomed & Pharmaceut Sci, Missoula, MT 59812 USA.
   [Joung, Hyojee] Seoul Natl Univ, Inst Hlth & Environm, Seoul 08826, South Korea.
C3 Seoul National University (SNU); Catholic University of Korea; Seoul
   National University (SNU); Purdue University System; Purdue University;
   Chung Ang University; National Cancer Center - Korea (NCC); University
   of Montana System; University of Montana; Seoul National University
   (SNU)
RP Joung, H (corresponding author), Seoul Natl Univ, Grad Sch Publ Hlth, Dept Publ Hlth, Seoul 08826, South Korea.; Joung, H (corresponding author), Seoul Natl Univ, Inst Hlth & Environm, Seoul 08826, South Korea.
EM subeen2466@snu.ac.kr; yjsong@catholic.ac.kr; jungelee@snu.ac.kr;
   jun24@purdue.edu; ivory8320@cau.ac.kr; gawie@ncc.re.kr;
   yoonhee.cho@umontana.edu; hjjoung@snu.ac.kr
RI Lee, Jung/AAC-5634-2020; Song, YoonJu/ABF-4594-2021; Cho,
   Yoon/AAN-6560-2021; Jun, Shinyoung/MUO-2043-2025; Joung,
   Hyojee/AAU-9502-2020; Stefanadis, Christodoulos/ABH-2232-2020
OI Wie, Gyung Ah/0000-0002-1503-3177; Song, YoonJu/0000-0002-4764-5864;
   Stefanadis, Christodoulos/0000-0001-5974-6454; Jun,
   Shinyoung/0000-0003-2452-4709; Cho, Yoon Hee/0000-0002-4290-7140; Lee,
   Jung Eun/0000-0003-1141-878X; Joung, Hyojee/0000-0003-1182-7786
FU 'Research Program for Agricultural Science and Technology Development',
   National Academy of Agricultural Science, Rural Development
   Administration [PJ011637022017]
FX This work was carried out with the support of 'Research Program for
   Agricultural Science and Technology Development', National Academy of
   Agricultural Science, Rural Development Administration (Project No.
   PJ011637022017).
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NR 58
TC 31
Z9 31
U1 2
U2 8
PU MDPI AG
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 2072-6643
J9 NUTRIENTS
JI Nutrients
PD OCT
PY 2017
VL 9
IS 10
AR 1055
DI 10.3390/nu9101055
PG 14
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA FM0DM
UT WOS:000414629900011
PM 28937597
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Obadia, N
   Lessa, MA
   Daliry, A
   Silvares, RR
   Gomes, F
   Tibiriçá, E
   Estato, V
AF Obadia, Nathalie
   Lessa, Marcos Adriano
   Daliry, Anissa
   Silvares, Raquel Rangel
   Gomes, Fabiana
   Tibirica, Eduardo
   Estato, Vanessa
TI Cerebral microvascular dysfunction in metabolic syndrome is exacerbated
   by ischemia-reperfusion injury
SO BMC NEUROSCIENCE
LA English
DT Article
DE Metabolic syndrome; Laser speckle contrast imaging (LSCI); Cerebral
   microvascular blood flow; Ischemia and reperfusion
ID HIGH-FAT DIET; ADIPOSE-TISSUE; INSULIN-RESISTANCE; BLOOD-FLOW;
   DEFINITION; STROKE; IMPACT; ATTACK; RISK; RATS
AB Background: Metabolic syndrome (MetS) is associated with an increased risk of cerebrovascular diseases, including cerebral ischemia. Microvascular dysfunction is an important feature underlying the pathophysiology of cerebrovascular diseases. In this study, we aimed to investigate the impacts of ischemia and reperfusion (IR) injury on the cerebral microvascular function of rats with high-fat diet-induced MetS.
   Results: We examined Wistar rats fed a high-fat diet (HFD) or normal diet (CTL) for 20 weeks underwent 30 min of bilateral carotid artery occlusion followed by 1 h of reperfusion (IR) or sham surgery. Microvascular blood flow was evaluated on the parietal cortex surface through a cranial window by laser speckle contrast imaging, functional capillary density, endothelial function and endothelial-leukocyte interactions by intravital videomicroscopy. Lipid peroxidation was assessed by TBARs analysis, the expression of oxidative enzymes and inflammatory markers in the brain tissue was analyzed by real-time PCR. The cerebral IR in MetS animals induced a functional capillary rarefaction (HFD IR 117 +/- 17 vs. CTL IR 224 +/- 35 capillary/mm(2); p < 0.05), blunted the endothelial response to acetylcholine (HFD IR -16.93% vs. CTL IR 16.19% from baseline inner diameter p < 0.05) and increased the endothelial-leukocyte interactions in the venules in the brain. The impact of ischemia on the cerebral microvascular blood flow was worsened in MetS animals, with a marked reduction of cerebral blood flow, exposing brain tissue to a higher state of hypoxia.
   Conclusions: Our results demonstrate that during ischemia and reperfusion, animals with MetS are more susceptible to alterations in the cerebral microcirculation involving endothelial dysfunction and oxidative stress events.
C1 [Obadia, Nathalie; Lessa, Marcos Adriano; Daliry, Anissa; Silvares, Raquel Rangel; Gomes, Fabiana; Tibirica, Eduardo; Estato, Vanessa] Fundacao Oswaldo Cruz, Lab Cardiovasc Invest, Ave Brasil 4365, BR-21045900 Rio De Janeiro, RJ, Brazil.
   [Tibirica, Eduardo] Natl Inst Cardiol, Rio De Janeiro, Brazil.
   [Estato, Vanessa] Fundacao Oswaldo Cruz, Inst Drug Technol, Rio De Janeiro, Brazil.
C3 Fundacao Oswaldo Cruz; Fundacao Oswaldo Cruz
RP Estato, V (corresponding author), Fundacao Oswaldo Cruz, Lab Cardiovasc Invest, Ave Brasil 4365, BR-21045900 Rio De Janeiro, RJ, Brazil.
EM estato@ioc.fiocruz.br
RI Daliry, Anissa/F-6256-2014; Estato, Vanessa/AAJ-9060-2020; lessa,
   marcos/JAC-2591-2023
OI Lessa, Marcos/0000-0002-4079-5704; Daliry, Anissa/0000-0001-7303-0030
FU CNPq, Rio de Janeiro, Brazil; FAPERJ, Rio de Janeiro, Brazil; FIOCRUZ,
   Rio de Janeiro, Brazil
FX Support was provided by CNPq, FAPERJ and FIOCRUZ, Rio de Janeiro,
   Brazil.
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NR 44
TC 28
Z9 28
U1 1
U2 10
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1471-2202
J9 BMC NEUROSCI
JI BMC Neurosci.
PD SEP 8
PY 2017
VL 18
AR 67
DI 10.1186/s12868-017-0384-x
PG 10
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA FG2DB
UT WOS:000409889300002
PM 28886695
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Pérez-Martínez, P
   García-Ríos, A
   Delgado-Lista, J
   Pérez-Jiménez, F
   López-Miranda, J
AF Perez-Martinez, Pablo
   Garcia-Rios, Antonio
   Delgado-Lista, Javier
   Perez-Jimenez, Francisco
   Lopez-Miranda, Jose
TI Mediterranean Diet Rich in Olive Oil and Obesity, Metabolic Syndrome and
   Diabetes Mellitus
SO CURRENT PHARMACEUTICAL DESIGN
LA English
DT Review
DE Mediterranean diet; olive oil; metabolic syndrome; diabetes mellitus;
   obesity; functional food; phenolic compounds; inflammation; oxidative
   stress
ID NF-KAPPA-B; RANDOMIZED CONTROLLED-TRIAL; POSTPRANDIAL ENDOTHELIAL
   FUNCTION; MONOUNSATURATED FATTY-ACIDS; CARDIOVASCULAR RISK-FACTORS;
   INSULIN-RESISTANT SUBJECTS; CORONARY-HEART-DISEASE; SUN PROSPECTIVE
   COHORT; BROWN ADIPOSE-TISSUE; BODY-MASS INDEX
AB After decades of epidemiological, clinical and experimental research, it has become clear that consumption of Mediterranean dietary patterns rich in olive oil has a profound influence on health outcomes, including obesity, metabolic syndrome (MetS) and diabetes mellitus. Traditionally, many beneficial properties associated with this oil have been ascribed to its high oleic acid content. Olive oil, however, is a functional food that, besides having high-monounsaturated (MUFA) content, contains other minor components with biological properties. In this line, phenolic compounds have shown antioxidant and antiinflammatory properties, prevent lipoperoxidation, induce favorable changes of lipid profile, improve endothelial function, and disclose antithrombotic properties. Research into the pharmacological properties of the minor components of olive oil is very active and could lead to the formulation of functional food and nutraceuticals. Although more data are mandatory the Mediterranean diet rich in olive oil does not contribute to obesity and appears to be a useful tool in the lifestyle management of the MetS. Moreover there is good scientific support for MUFA diets, especially those based on olive oil, as an alternative approach to low-fat diets for the medical nutritional therapy in diabetes. The objective of this review is to present evidence illustrating the relationship between Mediterranean diet, olive oil and metabolic diseases, including obesity, MetS and diabetes mellitus and to discuss potential mechanisms by which this food can help in disease prevention and treatment.
C1 [Lopez-Miranda, Jose] Univ Cordoba, Reina Sofia Univ Hospital, IMIBIC, Lipid & Atherosclerosis Unit, E-14071 Cordoba, Spain.
   [Lopez-Miranda, Jose] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr CIBEROBN, Madrid, Spain.
C3 Universidad de Cordoba; CIBER - Centro de Investigacion Biomedica en
   Red; CIBEROBN; Instituto de Salud Carlos III
RP López-Miranda, J (corresponding author), Univ Cordoba, Reina Sofia Univ Hospital, IMIBIC, Lipid & Atherosclerosis Unit, E-14071 Cordoba, Spain.
EM jlopezmir@uco.es
RI Lopez-Miranda, Jose/Y-8306-2019; Delgado-Lista, Javier/KAM-7412-2024;
   Jimenez, Francisco/AAJ-9559-2021; Tejada, Silvia/L-7297-2014; Perez
   Martinez, Pablo/AEL-6176-2022
OI Perez-Jimenez, Francisco/0000-0001-7499-7681; Perez Martinez,
   Pablo/0000-0001-7716-8117; Lopez-Miranda, Jose/0000-0002-8844-0718;
   Perez Jimenez, Francisco/0000-0001-9808-1280; Delgado Lista, Francisco
   Javier/0000-0002-2982-2716
FU Spanish Ministry of Science and Innovation [AGL2006-01979/ALI,
   AGL2009-12270, SAF2007/62005, PI10/01041]; Consejeria de Economia,
   Innovacion y Ciencia, Proyectos de Investigacion de Excelencia, Junta de
   Andalucia [CT5015, P06-CTS-01425]; Consejeria de Salud, Junta de
   Andalucia [07/43, PI 0193/09, PI-0252/2009, PI-0058-2010]; Centro de
   Excelencia Investigadora en Aceite de Oliva y Salud (CEAS); FEDER, Fondo
   Social Europeo; ISCIII
FX Ciber Fisiopatologia Obesidad y Nutricion, CIBEROBN, is an initiative of
   ISCIII government of Spain. This study was supported in part by research
   grants from the Spanish Ministry of Science and Innovation
   (AGL2006-01979/ALI, AGL2009-12270 to JL-M, SAF2007/62005 to FP-J and
   PI10/01041 to PP-M), Consejeria de Economia, Innovacion y Ciencia,
   Proyectos de Investigacion de Excelencia, Junta de Andalucia (CT5015 to
   FP-J and P06-CTS-01425 to JL-M); Consejeria de Salud, Junta de Andalucia
   (07/43, PI 0193/09 to JL-M, PI-0252/2009 to JD-L and PI-0058-2010 to
   PP-M). Also supported by Centro de Excelencia Investigadora en Aceite de
   Oliva y Salud (CEAS) and FEDER, Fondo Social Europeo. AG-R is supported
   by a research contract of ISCIII (Programa Rio-Hortega).
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NR 101
TC 140
Z9 153
U1 2
U2 71
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y26, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1381-6128
J9 CURR PHARM DESIGN
JI Curr. Pharm. Design
PD MAR
PY 2011
VL 17
IS 8
BP 769
EP 777
DI 10.2174/138161211795428948
PG 9
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 768PS
UT WOS:000290948400003
PM 21443484
DA 2025-06-11
ER

PT J
AU Shelton, RC
   Papakostas, GI
AF Shelton, Richard C.
   Papakostas, George I.
TI Augmentation of antidepressants with atypical antipsychotics for
   treatment-resistant major depressive disorder
SO ACTA PSYCHIATRICA SCANDINAVICA
LA English
DT Article
DE major depressive disorder; antidepressants; atypical antipsychotics;
   treatment resistant; augmentation
ID SEROTONIN REUPTAKE INHIBITORS; STAR-ASTERISK-D; DOUBLE-BLIND;
   OLANZAPINE/FLUOXETINE COMBINATION; ARIPIPRAZOLE AUGMENTATION;
   RISPERIDONE AUGMENTATION; DOPAMINERGIC-NEURONS; OPEN-LABEL; ZIPRASIDONE;
   OLANZAPINE
AB Objective: Atypical antipsychotics (AAPs) have been hypothesized to be beneficial in treatment-resistant depression (TRD). This paper will review a biochemical rationale and will summarize the data regarding the effectiveness of AAPs in TRD.
   Method: Studies were identified using searches of Pubmed/Medline, EMBase and the Cochrane databases by cross-referencing the term 'depression' with each of the six AAPs.
   Results: After initial positive, short case reports and clinical trials, larger studies failed to show the effectiveness of AAPs combined with antidepressants for TRD. More recently, larger scale clinical trials have supported the effectiveness of at least some of these medications. While AAPs have gained in popularity for TRD, there are nagging concerns regarding risks such as metabolic syndrome and tardive dyskinesia.
   Conclusion: The existing research provides some support for the beneficial effects of AAPs when combined with SSRI's in TRD. These medications pose significant risks that must be considered in their use.
C1 [Shelton, Richard C.] Vanderbilt Univ, Sch Med, Dept Psychiat, Nashville, TN 37212 USA.
   [Papakostas, George I.] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Dept Psychiat, Boston, MA USA.
C3 Vanderbilt University; Harvard University; Harvard Medical School;
   Harvard University Medical Affiliates; Massachusetts General Hospital
RP Shelton, RC (corresponding author), 1500 21st Ave S,Suite 2200, Nashville, TN 37212 USA.
EM richard.shelton@vanderbilt.edu
RI Shelton, Richard/AAC-4137-2022; Papakostas, George/I-6905-2013
FU NIMH NIH HHS [K23 MH069629, K24 MH01741] Funding Source: Medline
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NR 49
TC 87
Z9 92
U1 1
U2 10
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0001-690X
EI 1600-0447
J9 ACTA PSYCHIAT SCAND
JI Acta Psychiatr. Scand.
PD APR
PY 2008
VL 117
IS 4
BP 253
EP 259
DI 10.1111/j.1600-0447.2007.01130.x
PG 7
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 270YV
UT WOS:000253757000003
PM 18190674
DA 2025-06-11
ER

PT J
AU Yang, HB
   Chen, MP
   Liu, SS
   Zhang, YL
   Wang, LJ
   Duan, L
   Gong, FY
   Zhu, HJ
   Pan, H
AF Yang, Hongbo
   Chen, Meiping
   Liu, Shanshan
   Zhang, Yuelun
   Wang, Linjie
   Duan, Lian
   Gong, Fengying
   Zhu, Huijuan
   Pan, Hui
TI Association Between the Serum Level of Asprosin and Metabolic Parameters
   in Adult Growth Hormone Deficiency: A Cross-Sectional Study
SO INTERNATIONAL JOURNAL OF ENDOCRINOLOGY
LA English
DT Article
DE adult growth hormone deficiency; asprosin; metabolic syndrome
ID CARDIOVASCULAR RISK; REPLACEMENT THERAPY; INSULIN-RESISTANCE;
   DIABETES-MELLITUS; BODY-COMPOSITION; GH TREATMENT; GLUCOSE; ADIPONECTIN;
   PROFILE; STRESS
AB Objective: Adult growth hormone deficiency (AGHD) is characterized by central adiposity and metabolic disorders. Asprosin, a newly discovered adipokine, plays a crucial role in connecting adipose tissue function with the development of metabolic syndrome. This study aims to evaluate the circulating levels of asprosin in AGHD patients and explore the potential correlation between asprosin levels and various metabolic parameters.Subjects and Methods: Forty male patients with AGHD (mean age: 33.5 +/- 9.5 yrs and mean BMI: 25.0 +/- 4.5 kg/m2) and forty age-, gender-, and BMI-matched non-AGHD controls were enrolled. Medical history, anthropometric parameters (weight, height, waist circumference), and biochemical and hormonal investigations were collected from the electronic medical record system. Fat mass, fat percentage, and fat-free mass (FFM) were evaluated by bioelectrical impedance. Serum levels of asprosin were measured by ELISA.Results: Patients with AGHD demonstrated notably increased waist-to-hip ratios, triglyceride levels, and decreased HDL-cholesterol levels compared with the control group. In additionally, AGHD patients exhibited significantly higher serum levels of asprosin compared with controls (p=0.039). A notable association was observed between serum asprosin levels and FFM, triglycerides, and HDL-cholesterol levels in the whole population.Conclusions: Our study highlights distinct metabolic alterations in AGHD patients when matched for BMI with controls and investigates variations in serum asprosin levels for the first time. These findings have significant implications for identifying potential biomarkers for metabolic syndrome risk in AGHD patients and informing future treatment approaches.
C1 [Yang, Hongbo; Chen, Meiping; Liu, Shanshan; Wang, Linjie; Duan, Lian; Gong, Fengying; Zhu, Huijuan; Pan, Hui] Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Endocrinol, Key Lab Endocrinol Natl Hlth Commiss,State Key Lab, 1 Shuaifuyuan, Beijing, Peoples R China.
   [Zhang, Yuelun] Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Med Res Ctr, 1 Shuaifuyuan, Beijing, Peoples R China.
C3 Chinese Academy of Medical Sciences - Peking Union Medical College;
   Peking Union Medical College Hospital; Peking Union Medical College;
   Chinese Academy of Medical Sciences - Peking Union Medical College;
   Peking Union Medical College; Peking Union Medical College Hospital
RP Zhu, HJ; Pan, H (corresponding author), Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Endocrinol, Key Lab Endocrinol Natl Hlth Commiss,State Key Lab, 1 Shuaifuyuan, Beijing, Peoples R China.
EM yanghb@pumch.cn; 13512887609@163.com; liuss320@163.com;
   yuelunzhang@outlook.com; eileenwood@163.com; duanlianpumc@163.com;
   fygong@sina.com; shengxin2004@163.com; panhui@pumch.cn
RI Zhang, Yuelun/HHN-8411-2022
OI Zhang, Yuelun/0000-0001-7990-9003; , hongbo/0000-0003-2985-8265; Zhu,
   Huijuan/0000-0001-5172-6870
FU National Natural Science Foundation of China [81970678]; National High
   Level Hospital Clinical Research Funding [2022-PUMCH-A-249]; CAMS
   Innovation Fund for Medical Sciences [CIFMS 2021-I2M-1-003]
FX This work was supported by the National Natural Science Foundation of
   China (no. 81970678); National High Level <EM><STRONG>
   </STRONG></EM>Hospital Clinical Research Funding (2022-PUMCH-A-249); and
   CAMS Innovation Fund for Medical Sciences (CIFMS 2021-I2M-1-003).
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NR 44
TC 0
Z9 0
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1687-8337
EI 1687-8345
J9 INT J ENDOCRINOL
JI Int. J. Endocrinol.
PD NOV 19
PY 2024
VL 2024
AR 9735508
DI 10.1155/ije/9735508
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA N9G5I
UT WOS:001367335800001
PM 39610397
OA gold
DA 2025-06-11
ER

PT J
AU Nikolic, M
   Lazarevic, N
   Novakovic, J
   Jeremic, N
   Jakovljevic, V
   Zivkovic, V
   Bradic, J
   Pecarski, D
   Tel-Çayan, G
   Glamocija, J
   Sokovic, M
   Gregori, A
   Petrovic, J
AF Nikolic, Marina
   Lazarevic, Nevena
   Novakovic, Jovana
   Jeremic, Nevena
   Jakovljevic, Vladimir
   Zivkovic, Vladimir
   Bradic, Jovana
   Pecarski, Danijela
   Tel-Cayan, Gulsen
   Glamocija, Jasmina
   Sokovic, Marina
   Gregori, Andrej
   Petrovic, Jovana
TI Characterization, In Vitro Biological Activity and In Vivo
   Cardioprotective Properties of Trametes versicolor (L.:Fr.) Quel.
   Heteropolysaccharides in a Rat Model of Metabolic Syndrome
SO PHARMACEUTICALS
LA English
DT Article
DE Trametes versicolor; heteropolysaccharides; antioxidant; antimicrobial
   agent; metabolic syndrome; rat heart; cardioprotection
ID TAIL MEDICINAL MUSHROOM; CORIOLUS-VERSICOLOR; ANTITUMOR-ACTIVITY;
   GANODERMA-LUCIDUM; FRUITING BODIES; POLYSACCHARIDES; PURIFICATION;
   ELUCIDATION; INHIBITION
AB The present study aimed to examine the biological activity and cardioprotective potential of Trametes versicolor heteropolysaccharides (TVH) in a rat model of metabolic syndrome (MetS). This study included 40 Wistar rats divided into 5 groups: CTRL-healthy non-treated rats; MetS-non-treated rats; and H-TV, M-TV and L-TV-rats with MetS treated with either 300, 200 or 100 mg/kg TVH per os for 4 weeks. After finishing the treatment, we conducted an oral glucose tolerance test (OGTT), hemodynamic measurements and the animals were sacrificed, hearts isolated and subjected to the Langendorff technique. Blood samples were used for the determination of oxidative stress parameters, lipid status and insulin levels. We showed that & alpha;-amylase inhibition was not the mode of TVH antidiabetic action, while TVH showed a moderate inhibition of pathogenic microorganisms' growth (MIC 8.00 mg & BULL;mL(-1); MBC/MFC 16.00 mg & BULL;mL(-1)). H-TV and M-TV significantly reduced the level of prooxidants (O-2(-), H2O2, TBARS; p < 0.05), increased antioxidants activity (SOD, CAT, GSH; p < 0.05), reduced blood pressure (p < 0.05), improved glucose homeostasis in the OGTT test (p < 0.05), and ejection fraction (p < 0.05) and cardiac contractility (p < 0.05) compared to MetS (p < 0.05). Moreover, TVH treatment normalized the lipid status and decreased insulin levels compared to MetS rats (p < 0.05). The obtained results demonstrated that the TVH may be considered a useful agent for cardioprotection in MetS conditions.
C1 [Nikolic, Marina; Jakovljevic, Vladimir; Zivkovic, Vladimir] Univ Kragujevac, Fac Med Sci, Dept Physiol, Svetozara Markov 69, Kragujevac 34000, Serbia.
   [Nikolic, Marina; Lazarevic, Nevena; Novakovic, Jovana; Jeremic, Nevena; Jakovljevic, Vladimir; Zivkovic, Vladimir; Bradic, Jovana] Ctr Excellence Redox Balance Res Cardiovasc & Meta, Kragujevac 34000, Serbia.
   [Lazarevic, Nevena; Novakovic, Jovana; Jeremic, Nevena; Bradic, Jovana] Univ Kragujevac, Fac Med Sci, Dept Pharm, Svetozara Markov 69, Kragujevac 34000, Serbia.
   [Lazarevic, Nevena; Jakovljevic, Vladimir] IM Sechenov First Moscow State Med Univ, Dept Human Pathol, Moscow 119146, Russia.
   [Jeremic, Nevena] IM Sechenov First Moscow State Med Univ, Moscow 119991, Russia.
   [Zivkovic, Vladimir] IM Sechenov First Moscow State Med Univ, Inst Biodesign & Complex Syst Modelling, Dept Pharmacol, Moscow 119146, Russia.
   [Pecarski, Danijela] Acad Appl Studies Belgrade, Coll Hlth Sci, Belgrade 11000, Serbia.
   [Tel-Cayan, Gulsen] Mugla Sitki Kocman Univ, Mugla Vocat Sch, Dept Chem & Chem Proc Technol, TR-48000 Mugla, Turkiye.
   [Glamocija, Jasmina; Sokovic, Marina; Petrovic, Jovana] Univ Belgrade, Inst Biol Res Sinisa Stankovic, Natl Inst Republ Serbia, Bulevar Despota Stefana 142, Belgrade 11000, Serbia.
   [Gregori, Andrej] MycoMedica Ltd, Podkoren 72, Kranjska Gora 4280, Slovenia.
C3 University of Kragujevac; University of Kragujevac; Sechenov First
   Moscow State Medical University; Sechenov First Moscow State Medical
   University; Sechenov First Moscow State Medical University; Ministry of
   National Education - Turkey; Mugla Sitki Kocman University; University
   of Belgrade
RP Lazarevic, N (corresponding author), Ctr Excellence Redox Balance Res Cardiovasc & Meta, Kragujevac 34000, Serbia.; Lazarevic, N (corresponding author), Univ Kragujevac, Fac Med Sci, Dept Pharm, Svetozara Markov 69, Kragujevac 34000, Serbia.; Lazarevic, N (corresponding author), IM Sechenov First Moscow State Med Univ, Dept Human Pathol, Moscow 119146, Russia.; Petrovic, J (corresponding author), Univ Belgrade, Inst Biol Res Sinisa Stankovic, Natl Inst Republ Serbia, Bulevar Despota Stefana 142, Belgrade 11000, Serbia.
EM marina.rankovic.95@gmail.com; nevenasdraginic@gmail.com;
   jovana.jeremic@medf.kg.ac.rs; nbarudzic@hotmail.com;
   drvladakgbg@yahoo.com; vladimirziv@gmail.com; jovanabradickg@gmail.com;
   danijela.pecarski@assb.edu.rs; gulsentel@mu.edu.tr;
   jasna@ibiss.bg.ac.rs; marina.sokovic@nitra.gov.rs;
   andrej.gregori@zanaravo.com; jovana0303@ibiss.bg.ac.rs
RI Jeremic, Nevena/U-9443-2019; Zivkovic, Vladimir/AAP-6213-2020; Bradic,
   Jovana/ABH-9126-2020; Petrović, Jovana/ADM-7692-2022; Tel-Çayan,
   Gülsen/AAG-4351-2019; Glamoclija, Jasmina/JNS-9762-2023; Jakovljevic,
   Vladimir/V-1583-2019
OI Bradic, Jovana/0000-0001-5388-6085; Novakovic,
   Jovana/0000-0002-8084-3264; Nikolic, Marina/0000-0001-7829-5812;
   Draginic, Nevena/0000-0002-5386-8116; Glamoclija,
   Jasmina/0000-0001-6823-1137; Tel-Cayan, Gulsen/0000-0002-1916-7391;
   Petrovic, Jovana/0000-0002-9016-9971
FU Ministry of Science, Technological Development and Innovation, Republic
   of Serbia [451-03-47/2023-01/200007, 451-03-47/2023-01/200111]
FX The research was supported by the Ministry of Science, Technological
   Development and Innovation, Republic of Serbia through Grant Agreements
   with University of Belgrade-Institute for Biological Research Sinisa
   Stankovic; National Institute of Republic of Serbia No.
   451-03-47/2023-01/200007, and with University of Kragujevac-Faculty of
   Medical Sciences No. 451-03-47/2023-01/200111.
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   Zhang X, 2021, INT J BIOL MACROMOL, V166, P1387, DOI 10.1016/j.ijbiomac.2020.11.018
NR 55
TC 8
Z9 8
U1 2
U2 15
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1424-8247
J9 PHARMACEUTICALS-BASE
JI Pharmaceuticals
PD JUN
PY 2023
VL 16
IS 6
AR 787
DI 10.3390/ph16060787
PG 20
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA K3WO6
UT WOS:001015777500001
PM 37375735
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Akamine, Y
   Millman, JF
   Uema, T
   Okamoto, S
   Yonamine, M
   Uehara, M
   Kozuka, C
   Kaname, T
   Shimabukuro, M
   Kinjo, K
   Mitsuta, M
   Watanabe, H
   Masuzaki, H
AF Akamine, Yukari
   Millman, Jasmine F.
   Uema, Tsugumi
   Okamoto, Shiki
   Yonamine, Masato
   Uehara, Moriyuki
   Kozuka, Chisayo
   Kaname, Tadashi
   Shimabukuro, Michio
   Kinjo, Kozen
   Mitsuta, Masayo
   Watanabe, Hirosuke
   Masuzaki, Hiroaki
TI Fermented brown rice beverage distinctively modulates the gut microbiota
   in Okinawans with metabolic syndrome: A randomized controlled trial
SO NUTRITION RESEARCH
LA English
DT Article
DE Brown rice; Fermented beverage; Gut microbiota; Short chain fatty acids;
   Metabolic syndrome; Obesity syndrome
ID ENDOPLASMIC-RETICULUM STRESS; HIGH-FAT-DIET; GAMMA-ORYZANOL; INTESTINAL
   MICROBIOTA; WHITE RICE; OBESITY; IMPACT
AB Accumulating evidence to date suggests that brown rice is superior to white rice in regard to its beneficial impact on a number of risk factors of the metabolic syndrome (MetS). However, little is known about the influence of fermented brown rice beverage on the gut microbiota in humans. We therefore hypothesized that its impact would beneficially alter the gut microbiota composition of patients with MetS. Using a 4-week randomized, single-arm study design, subjects (n = 40) were advised to consume a daily fermented brown rice beverage (BA) or fermented white rice beverage (WA) as a replacement of their main meal. Clinical and anthropometric measurements as well as fecal samples were collected at baseline and immediately after completion of the intervention. Gut microbiota was analyzed using 16S ribosomal RNA sequencing and capillary electrophoresis-time-of-flight mass spectrometry was used to measure plasma short-chain fatty acids. Interestingly, ingestion of BA in contrast to WA resulted in a unique elevation in the abundance of number of beneficial species belonging to the Clostridia class, associated with reduced inflammation, and increased short-chain fatty acid production: Lactobacillales bacterium DJF B280 ( P = .005), Butyrate producing bacterium A2 207 ( P = .012), and Firmicutes bacterium DJF VP44 ( P = .038). This study demonstrates that consumption of BA is effective to beneficially modulate the gut microbiota compared with WA in patients with MetS.(c) 2022 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY license ( http://creativecommons.org/licenses/by/4.0/)
C1 [Akamine, Yukari; Millman, Jasmine F.; Uema, Tsugumi; Okamoto, Shiki; Uehara, Moriyuki; Masuzaki, Hiroaki] Univ Ryukyus, Grad Sch Med, Dept Med 2, Div Endocrinol, Nishihara, Okinawa, Japan.
   [Yonamine, Masato] Univ Tsukuba, Fac Med, Div Clin Med, Lab Lab Sports Med, Tsukuba, Ibaraki, Japan.
   [Kozuka, Chisayo] RIKEN, YCI Lab Metab Epigenet, Ctr Integrat Med Sci, Yokohama, Kanagawa, Japan.
   [Kaname, Tadashi] Natl Ctr Child Hlth & Dev, Dept Genome Med, Tokyo, Japan.
   [Shimabukuro, Michio] Fukushima Med Univ, Sch Med, Dept Diabet Endocrinol & Metab, Fukushima, Japan.
   [Kinjo, Kozen] Okinawa Hlth Promot Fdn, Onna, Okinawa, Japan.
   [Mitsuta, Masayo] Aizu Tenpo Co Ltd, Fukushima, Japan.
   [Watanabe, Hirosuke] Japan Sci & Technol Agcy JST, Ind Acad Collaborat, Fukushima, Japan.
   [Okamoto, Shiki; Masuzaki, Hiroaki] 207 Uehara, Nishihara, Okinawa 9030215, Japan.
C3 University of the Ryukyus; University of Tsukuba; RIKEN; National Center
   for Child Health & Development - Japan; Fukushima Medical University;
   Japan Science & Technology Agency (JST)
RP Okamoto, S; Masuzaki, H (corresponding author), 207 Uehara, Nishihara, Okinawa 9030215, Japan.
EM shiki@med.u-ryukyu.ac.jp; hiroaki@med.u-ryukyu.ac.jp
RI Kozuka, Chisayo/KEZ-9801-2024; Okamoto, Shiki/X-7274-2018
OI Okamoto, Shiki/0000-0002-2802-0527
FU Japan Society for the Promotion of Science (JSPS) , KAKENHI [20K08912];
   Japan Agency for Medical Research and Development (AMED)
   [JP19ek0410049]; Construction of Okinawa Science and Technology
   Innovation System; Setsuro Fuji Memorial the Osaka Foundation for
   Promotion of Fundamental Medical Research; Medical Rice Association;
   Council for Science, Technology and Innovation, Cross-ministerial
   Strategic Innovation Promotion Program, "Technologies for Creating
   Next-generation Agriculture, Forestry and Fisheries."; Grants-in-Aid for
   Scientific Research [20K08912, 21K14819] Funding Source: KAKEN
FX The present study was supported in part by Grants-in-Aid from the Japan
   Society for the Promotion of Science (JSPS) , KAKENHI (grant numbers:
   20K08912, 18K11079) ; Japan Agency for Medical Research and Development
   (AMED) (grant number: JP19ek0410049) ; Construction of Okinawa Science
   and Technology Innovation System; Setsuro Fuji Memorial the Osaka
   Foundation for Promotion of Fundamental Medical Re-search; Medical Rice
   Association and Council for Science, Technology and Innovation,
   Cross-ministerial Strategic Innovation Promotion Program, "Technologies
   for Creating Next-generation Agriculture, Forestry and Fisheries." JSPS,
   AMED, Construction of Okinawa Science and Technology Innovation System,
   Setsuro Fuji Memorial the Osaka Foundation for Promotion of Fundamental
   Medical Research, Medical Rice Association and Council for Science,
   Technology and Innovation, Cross-ministerial Strategic Innovation
   Promotion Program, "Technologies for Creating Next-generation
   Agriculture, Forestry and Fisheries," had no role in the study design,
   collection, analysis, interpretation, or writing of this article.
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NR 45
TC 15
Z9 15
U1 2
U2 26
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0271-5317
EI 1879-0739
J9 NUTR RES
JI Nutr. Res.
PD JUL
PY 2022
VL 103
BP 68
EP 81
DI 10.1016/j.nutres.2022.03.013
EA APR 2022
PG 14
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 1N0XC
UT WOS:000800385900008
PM 35500381
OA hybrid
DA 2025-06-11
ER

PT J
AU Nibali, L
   Donos, N
   Terranova, V
   Di Pino, A
   Di Marca, S
   Ferrara, V
   Pisano, M
   Scicali, R
   Rabuazzo, AM
   Purrello, F
   Malatino, L
AF Nibali, Luigi
   Donos, Nikos
   Terranova, Valentina
   Di Pino, Antonino
   Di Marca, Salvatore
   Ferrara, Viviana
   Pisano, Marcella
   Scicali, Roberto
   Rabuazzo, Agata Maria
   Purrello, Francesco
   Malatino, Lorenzo
TI Left ventricular geometry and periodontitis in patients with the
   metabolic syndrome
SO CLINICAL ORAL INVESTIGATIONS
LA English
DT Article
DE Metabolic syndrome; Periodontitis; Periodontal medicine; Cardiovascular
   disease
ID INTIMA-MEDIA THICKNESS; CLINICAL-IMPLICATIONS; INSULIN-RESISTANCE;
   DIABETES-MELLITUS; ASSOCIATION; MASS; DISEASE; RISK; ATHEROSCLEROSIS;
   POPULATION
AB ObjectiveThe presence of periodontal disease (PD) in subjects affected by the metabolic syndrome (MetS) may affect their risk of developing cardiovascular disease. The aim of this cross-sectional study was to investigate the systemic impact of PD in MetS, by assessing measures of sub-clinical atherosclerosis and left ventricular mass and geometry.Materials and methodsA total of 103 patients undergoing treatment for MetS were examined for confirmation of diagnosis, blood sampling, and measures of pulse wave velocity (PWV), carotid intima-media thickness (c-IMT), left ventricular mass index (LVM), and relative wall thickness (RWT). All subjects underwent a detailed dental assessment, including measurements of DMFT (decayed-missing-filled teeth) and periodontal parameters.ResultsTen patients (10%) were diagnosed with healthy-mild periodontitis, 38 patients (37%) were diagnosed in the moderate periodontitis group, and 55 (53%) had severe periodontitis. A total of 37% of subjects were affected by dental caries. Linear regression analysis revealed that patients with severe PD had increased average ventricular RWT (adjusted p=0.032). Average full mouth probing pocket depth (PPD) was also associated with RWT (adjusted p=0.006). No associations between PD and c-IMT, PWV, and LVM were detected after adjusted analyses.ConclusionThis study suggests that periodontitis may be associated with concentric left ventricular remodeling, a predictive index of cardiovascular events.Clinical relevanceThe presence of periodontitis in patients with MetS might have an effect on left ventricular geometry. These findings stress the importance of prevention, diagnosis, and management of periodontitis in patients with MetS.Trail registrationNCT03297749
C1 [Nibali, Luigi; Donos, Nikos] Queen Mary Univ London, Barts & London Sch Med & Dent, Inst Dent, Ctr Oral Immunobiol & Regenerat Med, Turner St, London E1 2AD, England.
   [Nibali, Luigi; Donos, Nikos] Queen Mary Univ London, Barts & London Sch Med & Dent, Inst Dent, Ctr Oral Clin Res, Turner St, London E1 2AD, England.
   [Terranova, Valentina; Di Marca, Salvatore; Pisano, Marcella; Malatino, Lorenzo] Univ Catania, Dept Clin & Expt Med, Osped Cannizzaro, Catania, Italy.
   [Di Pino, Antonino; Ferrara, Viviana; Scicali, Roberto; Rabuazzo, Agata Maria; Purrello, Francesco] Univ Catania, Osped Garibaldi Nesima, Dept Clin & Expt Med, Catania, Italy.
C3 University of London; Queen Mary University London; University of
   London; Queen Mary University London; University of Catania; University
   of Catania; Presidio Ospedaliero Garibaldi-Nesima
RP Nibali, L (corresponding author), Queen Mary Univ London, Barts & London Sch Med & Dent, Inst Dent, Ctr Oral Immunobiol & Regenerat Med, Turner St, London E1 2AD, England.; Nibali, L (corresponding author), Queen Mary Univ London, Barts & London Sch Med & Dent, Inst Dent, Ctr Oral Clin Res, Turner St, London E1 2AD, England.
EM l.nibali@qmul.ac.uk
RI Scicali, Roberto/L-9587-2019; Malatino, Lorenzo/I-7319-2018; Di Pino,
   Antonino/ISB-0312-2023; Purrello, Francesco/K-9721-2016
OI Scicali, Roberto/0000-0002-7023-3649; PURRELLO, Francesco
   Salvatore/0000-0003-3313-8543; MALATINO, Lorenzo
   Salvatore/0000-0003-2944-2729
FU Department of Research Plan of the University of Catania, Department of
   Clinical and Experimental Medicine [A]
FX This study was funded by internal University funds and partially by the
   2016/2018 Department of Research Plan of the University of Catania,
   Department of Clinical and Experimental Medicine (project no. A).
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NR 36
TC 17
Z9 17
U1 0
U2 3
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1432-6981
EI 1436-3771
J9 CLIN ORAL INVEST
JI Clin. Oral Investig.
PD JUN
PY 2019
VL 23
IS 6
BP 2695
EP 2703
DI 10.1007/s00784-018-2667-8
PG 9
WC Dentistry, Oral Surgery & Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dentistry, Oral Surgery & Medicine
GA HX5ME
UT WOS:000467444800014
PM 30350134
OA hybrid, Green Submitted
DA 2025-06-11
ER

PT J
AU Ashford, AL
   Dunkley, TPJ
   Cockerill, M
   Rowlinson, RA
   Baak, LM
   Gallo, R
   Balmanno, K
   Goodwin, LM
   Ward, RA
   Lochhead, PA
   Guichard, S
   Hudson, K
   Cook, SJ
AF Ashford, Anne L.
   Dunkley, Tom P. J.
   Cockerill, Mark
   Rowlinson, Rachel A.
   Baak, Lisa M.
   Gallo, Raffaella
   Balmanno, Kathryn
   Goodwin, Louise M.
   Ward, Richard A.
   Lochhead, Pamela A.
   Guichard, Sylvie
   Hudson, Kevin
   Cook, Simon J.
TI Identification of DYRK1B as a substrate of ERK1/2 and characterisation
   of the kinase activity of DYRK1B mutants from cancer and metabolic
   syndrome
SO CELLULAR AND MOLECULAR LIFE SCIENCES
LA English
DT Article
DE DYRK1B; ERK1/2; KRAS; Phosphorylation; Protein kinase; RAF
ID PROTEIN-KINASE; REGULATED KINASE; CYCLIN D1; PANCREATIC-CANCER; MEDIATES
   SURVIVAL; BH3-ONLY PROTEIN; MIRK/DYRK1B; SPECIFICITY; INHIBITOR;
   PHOSPHORYLATION
AB The dual-specificity tyrosine-phosphorylation-regulated kinase, DYRK1B, is expressed de novo during myogenesis, amplified or mutated in certain cancers and mutated in familial cases of metabolic syndrome. DYRK1B is activated by cis auto-phosphorylation on tyrosine-273 (Y273) within the activation loop during translation but few other DYRK1B phosphorylation sites have been characterised to date. Here, we demonstrate that DYRK1B also undergoes trans-autophosphorylation on serine-421 (S421) in vitro and in cells and that this site contributes to DYRK1B kinase activity. Whilst a DYRK1B(S421A) mutant was completely defective for p-S421 in cells, DYRK1B inhibitors caused only a partial loss of p-S421 suggesting the existence of an additional kinase that could also phosphorylate DYRK1B S421. Indeed, a catalytically inactive DYRK1B(D239A) mutant exhibited very low levels of p-S421 in cells but this was increased by KRAS(G12V). In addition, selective activation of the RAF-MEK1/2-ERK1/2 signalling pathway rapidly increased p-S421 in cells whereas activation of the stress kinases JNK or p38 could not. S421 resides within a Ser-Pro phosphoacceptor motif that is typical for ERK1/2 and recombinant ERK2 phosphorylated DYRK1B at S421 in vitro. Our results show that DYRK1B is a novel ERK2 substrate, uncovering new links between two kinases involved in cell fate decisions. Finally, we show that DYRK1B mutants that have recently been described in cancer and metabolic syndrome exhibit normal or reduced intrinsic kinase activity.
C1 [Ashford, Anne L.; Baak, Lisa M.; Gallo, Raffaella; Balmanno, Kathryn; Lochhead, Pamela A.; Cook, Simon J.] Babraham Inst, Signalling Lab, Babraham Res Campus, Cambridge CB22 3AT, England.
   [Dunkley, Tom P. J.; Cockerill, Mark; Rowlinson, Rachel A.; Goodwin, Louise M.; Ward, Richard A.; Guichard, Sylvie; Hudson, Kevin] AstraZeneca, Alderley Pk, Macclesfield SK10 4TG, Cheshire, England.
   [Dunkley, Tom P. J.] Roche Innovat Ctr Basel, Basel, Switzerland.
   [Cockerill, Mark] Univ Manchester, Paterson Inst Canc Res, Manchester M20 4BX, Lancs, England.
   [Guichard, Sylvie] AstraZeneca, Waltham, MA 02451 USA.
C3 UK Research & Innovation (UKRI); Biotechnology and Biological Sciences
   Research Council (BBSRC); Babraham Institute; AstraZeneca; Roche
   Holding; Paterson Institute for Cancer Research; University of
   Manchester; AstraZeneca
RP Ashford, AL; Cook, SJ (corresponding author), Babraham Inst, Signalling Lab, Babraham Res Campus, Cambridge CB22 3AT, England.
EM anne.ashford@babraham.ac.uk; simon.cook@babraham.ac.uk
RI Gallo, Raffaella/IAN-3536-2023
OI Lochhead, Pamela/0000-0001-7498-0177; Baak, Lisa/0000-0001-5274-6371;
   Cook, Simon/0000-0001-9087-1616; Gallo, Raffaella/0000-0003-1234-5551;
   Balmanno, Kathryn/0000-0002-6417-3889
FU Biotechnology and Biological Sciences Research Council (BBSRC)
   [3068901]; BBSRC [BBS/E/B/000C0417, BB/L008793/1]; Association for
   International Cancer Research [AICR09-0257]; Erasmus Programme; BBSRC
   [BBS/E/B/000C0417, BB/L008793/1] Funding Source: UKRI
FX This work was supported by a Biotechnology and Biological Sciences
   Research Council (BBSRC) CASE PhD studentship [grant number 3068901
   (supporting A. A.)] awarded to AstraZeneca and the Babraham Institute
   (to S.C.), a BBSRC Institute Strategic Programme Grant [grant number
   BBS/E/B/000C0417 (to S.C.)], a BBSRC Project Grant [grant number
   BB/L008793/1 (to S.C)] and in part by the Association for International
   Cancer Research via a project grant [grant number AICR09-0257 (to S.C.].
   Lisa Baak, a visiting Masters student from the University of
   Duisburg-Essen, and Raffaella Gallo, were supported by scholarships from
   the Erasmus Programme.
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NR 57
TC 26
Z9 31
U1 0
U2 8
PU SPRINGER BASEL AG
PI BASEL
PA PICASSOPLATZ 4, BASEL, 4052, SWITZERLAND
SN 1420-682X
EI 1420-9071
J9 CELL MOL LIFE SCI
JI Cell. Mol. Life Sci.
PD FEB
PY 2016
VL 73
IS 4
BP 883
EP 900
DI 10.1007/s00018-015-2032-x
PG 18
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA DC9IQ
UT WOS:000369535300013
PM 26346493
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Santos, ABS
   Junges, M
   Silvello, D
   Macari, A
   de Araújo, BS
   Seligman, BG
   Duncan, BB
   Rohde, LEP
   Clausell, N
   Foppa, M
AF Santos, Angela B. S.
   Junges, Mauricio
   Silvello, Daiane
   Macari, Adriana
   de Araujo, Bruno S.
   Seligman, Beatriz G.
   Duncan, Bruce B.
   Rohde, Luis Eduardo P.
   Clausell, Nadine
   Foppa, Murilo
TI Early Change of Extracellular Matrix and Diastolic Parameters in
   Metabolic Syndrome
SO ARQUIVOS BRASILEIROS DE CARDIOLOGIA
LA English
DT Article
DE Metabolic Syndrome; Risk Factors; Extracellular Matrix; Diastole /
   physiopathology
ID ADULTS; ECHOCARDIOGRAPHY; RECOMMENDATIONS; PREVALENCE
AB Background: Metabolic syndrome (MS) is associated with increased cardiovascular risk. It is not clear whether myocardial changes showed in this syndrome, such as diastolic dysfunction, are due to the systemic effects of the syndrome, or to specific myocardial effects.
   Objectives: Compare diastolic function, biomarkers representing extracellular matrix activity (ECM), inflammation and cardiac hemodynamic stress in patients with the MS and healthy controls.
   Methods: MS patients (n = 76) and healthy controls (n=30) were submitted to a clinical assessment, echocardiographic study, and measurement of plasma levels of metalloproteinase-9 (MMP9), tissue inhibitor of metalloproteinase-1 (TIMP1), ultrasensitive-reactive-C-Protein (us-CRP), insulin resistance (HOMA-IR) and natriuretic peptide (NT-proBNP).
   Results: MS group showed lower E'wave (10.1 +/- 3.0 cm/s vs 11.9 +/- 2.6 cm/s, p = 0.005), increased A wave (63.4 +/- 14.1 cm/s vs. 53.1 +/- 8.9 cm/s; p < 0.001), E/E' ratio (8.0 +/- 2.2 vs. 6.3 +/- 1.2; p < 0.001), MMP9 (502.9 +/- 237.1 ng / mL vs. 330.4 +/- 162.7 ng/mL; p < 0.001), us-CRP (p = 0.001) and HOMA-IR (p < 0.001), but no difference for TIMP1 or NT-proBNP levels. In a multivariable analysis, only MMP9 was independently associated with MS.
   Conclusion: MS patients showed differences for echocardiographic measures of diastolic function, ECM activity, us-CRP and HOMA-IR when compared to controls. However, only MMP9 was independently associated with the MS. These findings suggest that there are early effects on ECM activity, which cannot be tracked by routine echocardiographic measures of diastolic function.
C1 [Santos, Angela B. S.; Seligman, Beatriz G.; Rohde, Luis Eduardo P.; Clausell, Nadine; Foppa, Murilo] Hosp Clin Porto Alegre, BR-90035903 Porto Alegre, RS, Brazil.
   [Santos, Angela B. S.; Junges, Mauricio; Silvello, Daiane; Macari, Adriana; de Araujo, Bruno S.; Seligman, Beatriz G.; Duncan, Bruce B.; Rohde, Luis Eduardo P.; Clausell, Nadine; Foppa, Murilo] Univ Fed Rio Grande do Sul, Porto Alegre, RS, Brazil.
C3 Hospital de Clinicas de Porto Alegre; Universidade Federal do Rio Grande
   do Sul
RP Santos, ABS (corresponding author), Hosp Clin Porto Alegre, Div Cardiovasc, Rua Ramiro Barcelos 2350,Sala 2061, BR-90035903 Porto Alegre, RS, Brazil.
EM angelabssantos@yahoo.com.br
RI Clausell, Nadine/C-7813-2016; Silvello, Daiane/U-5515-2019; Santos,
   Angela/V-5871-2019; Foppa, Murilo/V-4845-2019; Rohde, Luis/I-4216-2013;
   Duncan, Bruce/L-4140-2016
OI Duncan, Bruce/0000-0002-7491-2630
FU CNPq; FIPE/HCPA
FX This study was funded by CNPq and FIPE/HCPA.
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NR 24
TC 7
Z9 7
U1 0
U2 2
PU ARQUIVOS BRASILEIROS CARDIOLOGIA
PI RIO DE JANEIRO
PA AVENIDA MARECHAL CAMARA 160-330 CENTRO, RIO DE JANEIRO, RJ 20 020-907,
   BRAZIL
SN 0066-782X
EI 1678-4170
J9 ARQ BRAS CARDIOL
JI Arq. Bras. Cardiol.
PD OCT
PY 2013
VL 101
IS 4
BP 311
EP 316
DI 10.5935/abc.20130182
PG 6
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 278PC
UT WOS:000328901200009
PM 24008653
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Tanofsky-Kraff, M
   Shomaker, LB
   Stern, EA
   Miller, R
   Sebring, N
   DellaValle, D
   Yanovski, SZ
   Hubbard, VS
   Yanovski, JA
AF Tanofsky-Kraff, M.
   Shomaker, L. B.
   Stern, E. A.
   Miller, R.
   Sebring, N.
   DellaValle, D.
   Yanovski, S. Z.
   Hubbard, V. S.
   Yanovski, J. A.
TI Children's binge eating and development of metabolic syndrome
SO INTERNATIONAL JOURNAL OF OBESITY
LA English
DT Article
DE binge eating; metabolic syndrome; children; adolescents; longitudinal
   studies
ID ADOLESCENTS; RISK; WEIGHT; TRIGLYCERIDE; ADIPOSITY; INSULIN;
   DISTRIBUTIONS; BEHAVIORS; OBESITY; STRESS
AB BACKGROUND: Binge eating predisposes children to excessive weight gain. However, it is unknown if pediatric binge eating predicts other obesity-associated adverse health outcomes.
   OBJECTIVE: The objective of this study was to investigate the relationship between binge eating and metabolic syndrome (MetS) in children.
   METHOD: Children aged 5-12 years at high risk for adult obesity, either because they were overweight/obese when first examined or because their parents were overweight/obese, were recruited from Washington, DC and its suburbs. Children completed a questionnaire assessment of binge eating at baseline and underwent measurements of MetS components at baseline and at a follow-up visit approximately 5 years later. Magnetic resonance imaging was used to measure the visceral adipose tissue (VAT) in a subset.
   RESULTS: In all, 180 children were studied between July 1996 and August 2010. Baseline self-reported binge eating presence was associated with a 5.33 greater odds of having MetS at follow-up (95% confidence interval (CI): 1.47, 19.27, P = 0.01). The association between binge eating and body mass index (BMI) only partially explained changes in MetS components: baseline binge eating predicted higher follow-up triglycerides, even after accounting for baseline triglycerides, baseline BMI, BMI change, sex, race, baseline age and time in study (P = 0.05). Also, adjusting for baseline VAT and demographics, baseline binge eating predicted greater follow-up L2-3 VAT (P = 0.01).
   DISCUSSION: Children's reports of binge eating predicted development of MetS, worsening triglycerides and increased VAT. The excessive weight gain associated with children's binge eating partly explained its adverse metabolic health outcomes. Reported binge eating may represent an early behavioral marker upon which to focus interventions for obesity and MetS.
C1 [Tanofsky-Kraff, M.; Shomaker, L. B.; Stern, E. A.; Miller, R.; Yanovski, S. Z.; Yanovski, J. A.] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Program Dev Endocrinol & Genet, Sect Growth & Obes, NIH,DHHS,Hatfield Clin Res Ctr, Bethesda, MD 20892 USA.
   [Tanofsky-Kraff, M.; Shomaker, L. B.; Miller, R.] Uniformed Serv Univ Hlth Sci, Dept Med & Clin Psychol, Bethesda, MD 20814 USA.
   [Sebring, N.; DellaValle, D.] NIH, Ctr Clin, Dept Nutr, Bethesda, MD 20892 USA.
   [Yanovski, S. Z.] NIDDKD, Div Digest Dis & Nutr, Bethesda, MD 20892 USA.
   [Hubbard, V. S.] NIH, Div Nutr Res Coordinat, Bethesda, MD 20892 USA.
C3 National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver
   National Institute of Child Health & Human Development (NICHD);
   Uniformed Services University of the Health Sciences - USA; National
   Institutes of Health (NIH) - USA; NIH Clinical Center (CC); National
   Institutes of Health (NIH) - USA; NIH National Institute of Diabetes &
   Digestive & Kidney Diseases (NIDDK); National Institutes of Health (NIH)
   - USA
RP Yanovski, JA (corresponding author), Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Program Dev Endocrinol & Genet, Sect Growth & Obes, NIH,DHHS,Hatfield Clin Res Ctr, 10 Ctr Dr,Room 1E-3330,MSC 1103, Bethesda, MD 20892 USA.
EM jy15i@nih.gov
OI Yanovski, Jack/0000-0001-8542-1637; Radin, Rachel/0000-0003-3776-9481;
   DellaValle, Diane M./0000-0002-3855-432X
FU NICHD [1F32HD056762, 1ZIAHD000641]; NIMHD
FX The authors' responsibilities were as follows: MTK, LBS, SZY and JAY
   designed the study; MTK, LBS, EAS, RM, NS, DD, SZY, VSH and JAY analyzed
   and interpreted the data and drafted of the manuscript. All authors
   contributed to the collection and assembly of data, provided critical
   revision of the article for content and approved the final version of
   the manuscript. We thank the volunteers who participated for their help
   in completing these studies. The funding organization played no role in
   design and conduct of the study; collection, management, analysis and
   interpretation of the data; nor preparation or review of the manuscript.
   None of the authors declare any conflict of interest. This work was
   supported by National Research Service Award 1F32HD056762 from the NICHD
   (to LBS) and Intramural Research Program Grant 1ZIAHD000641 from the
   NICHD with supplemental funding from NIMHD (to JAY). ClinicalTrials.gov
   IDs: NCT00001522, NCT00001195.
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NR 44
TC 96
Z9 101
U1 2
U2 21
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0307-0565
EI 1476-5497
J9 INT J OBESITY
JI Int. J. Obes.
PD JUL
PY 2012
VL 36
IS 7
BP 956
EP 962
DI 10.1038/ijo.2011.259
PG 7
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 972JL
UT WOS:000306273300011
PM 22234282
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Valenti, L
   Dongiovanni, P
   Motta, BM
   Swinkels, DW
   Bonara, P
   Rametta, R
   Burdick, L
   Frugoni, C
   Fracanzani, AL
   Fargion, S
AF Valenti, Luca
   Dongiovanni, Paola
   Motta, Benedetta Maria
   Swinkels, Dorine W.
   Bonara, Paola
   Rametta, Raffaela
   Burdick, Larry
   Frugoni, Cecelia
   Fracanzani, Anna Ludovica
   Fargion, Silvia
TI Serum Hepcidin and Macrophage Iron Correlate With MCP-1 Release and
   Vascular Damage in Patients With Metabolic Syndrome Alterations
SO ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
LA English
DT Article
DE atherosclerosis; cytokines; free radicals/free-radical scavengers;
   macrophages; risk factors; iron
ID CORONARY-HEART-DISEASE; MONOCYTE CHEMOATTRACTANT PROTEIN-1; HFE
   GENE-MUTATIONS; OXIDATIVE STRESS; HEMOCHROMATOSIS; LIVER; RISK;
   EXPRESSION; STORES; ATHEROSCLEROSIS
AB Objective-Increased body iron stores and hepcidin have been hypothesized to promote atherosclerosis by inducing macrophage iron accumulation and release of cytokines, but direct demonstration in human cells is lacking. The aim of this study was to evaluate the effect of iron on cytokine release in monocytes ex vivo and the correlation with vascular damage and to evaluate the relationship among serum levels of hepcidin, cytokines, and vascular damage in patients with metabolic syndrome alterations.
   Methods and Results-Manipulation of iron status with ferric ammonium citrate and hepcidin-25 induced monocyte chemoattractant protein (MCP)-1 and interleukin-6 in human differentiating monocytes of patients with hyperferritinemia associated with the metabolic syndrome (n = 11), but not in subjects with hemochromatosis or HFE mutations impairing iron accumulation (n = 15), and the degree of induction correlated with the presence of carotid plaques, detected by echocolor-Doppler. In monocytes of healthy subjects (n = 7), iron and hepcidin increased the mRNA levels and release of MCP-1, but not of interleukin-6. In 130 patients with metabolic alterations, MCP-1 levels, as detected by ELISA, were correlated with hepcidin-25 measured by time-of-flight mass spectrometry (P = 0.005) and were an independent predictor of the presence of carotid plaques (P = 0.05).
   Conclusion-Hepcidin and macrophage iron correlate with MCP-1 release and vascular damage in high-risk individuals with metabolic alterations. (Arterioscler Thromb Vasc Biol. 2011;31:683-690.)
C1 [Valenti, Luca] Univ Milan, Osped Maggiore Policlin Ca Granda IRCCS, Dept Internal Med, Ctr Malattie Metab Fegato, I-20122 Milan, Italy.
   [Swinkels, Dorine W.] Radboud Univ Nijmegen, Med Ctr, Dept Lab Med, Lab Genet Endocrine & Metab Dis, NL-6525 ED Nijmegen, Netherlands.
C3 University of Milan; IRCCS Ca Granda Ospedale Maggiore Policlinico;
   Radboud University Nijmegen
RP Valenti, L (corresponding author), Univ Milan, Osped Maggiore Policlin Ca Granda IRCCS, Dept Internal Med, Ctr Malattie Metab Fegato, Via F Sforza 35, I-20122 Milan, Italy.
EM luca.valenti@unimi.it
RI Dongiovanni, Paola/AAC-9965-2019; Swinkels, Dorine/H-8098-2014; Motta,
   Benedetta/AAA-8559-2020; Fracanzani, Anna Ludovica/J-8986-2018; Valenti,
   Luca/B-3695-2009
OI Dongiovanni, Paola/0000-0003-4343-7213; rametta,
   raffaela/0000-0003-0091-9394; Fracanzani, Anna
   Ludovica/0000-0001-5918-0171; Motta, Benedetta
   Maria/0000-0002-6681-2170; Valenti, Luca/0000-0001-8909-0345
FU University of Milano; Ricerca Corrente; Progetto a Concorso
FX This work was supported by FIRST/PUR University of Milano 2006-2008;
   Ricerca Corrente 2006, 2007; and Progetto a Concorso 2009-2010
   Fondazione Ospedale Policlinico MaRE IRCCS.
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NR 49
TC 81
Z9 87
U1 1
U2 10
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1079-5642
EI 1524-4636
J9 ARTERIOSCL THROM VAS
JI Arterioscler. Thromb. Vasc. Biol.
PD MAR
PY 2011
VL 31
IS 3
BP 683
EP 690
DI 10.1161/ATVBAHA.110.214858
PG 8
WC Hematology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Hematology; Cardiovascular System & Cardiology
GA 722CZ
UT WOS:000287409900031
PM 21183736
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Mauss, D
   Herr, RM
   Jarczok, MN
   Motoc, I
   Fischer, JE
   Bosch, A
AF Mauss, Daniel
   Herr, Raphael M.
   Jarczok, Marc N.
   Motoc, Irina
   Fischer, Joachim E.
   Bosch, A.
TI The association of cortisol levels with leukocyte distribution is
   disrupted in the metabolic syndrome
SO OBESITY RESEARCH & CLINICAL PRACTICE
LA English
DT Article
DE metabolic syndrome; inflammation; glucocorticoid sensitivity;
   glucocorticoid resistance; cortisol
ID CORONARY-HEART-DISEASE; C-REACTIVE PROTEIN; GLUCOCORTICOID SENSITIVITY;
   SALIVARY CORTISOL; RISK-FACTORS; RESISTANCE; INFLAMMATION; PREVALENCE;
   MECHANISMS; STRESS
AB Background: Leukocyte glucocorticoid sensitivity (GCS) pertains to the responsivity of leukocytes to the regulating actions of glucocorticoids, such as cortisol. Impaired endocrine regulation may link the metabolic syndrome (MetS) to the development of cardiovascular disease. We tested if the physiological association between endogenous cortisol levels and peripheral leukocyte composition becomes disrupted in individuals with MetS. Methods: MetS was assessed among 689 German industrial employees. The covariance between cortisol levels and hematologic parameters (i.e., proportions of neutrophils and lymphocytes) and their ratio was explored, which has been proposed as a proxy for GCS in vivo. Cortisol level before blood collection was assessed by repeated saliva collection, and the area under the curve was calculated. Linear regression models were adjusted for potential confounders including age, gender, BMI, income, and lifestyle factors. Results: Cortisol levels did not differ between subgroups. Participants without MetS (n = 552) showed the expected association of cortisol with hematologic parameters (i3 = 0.207 to 0.216; p values 0.001). No association (i3 = 0.078 to 0.083; p values 0.10) was found among those with MetS (n = 137), consistent with a reduced GCS. Analyses of separate MetS components showed that reduced GCS was associated specifically with decreased high-density lipoprotein and elevated fasting plasma glucose. Conclusions: Utilizing a novel statistical approach to infer GCS, this study provided first epidemiological evidence of aberrant physiological regulation of leukocyte distribution by endogenous cortisol levels among individuals with MetS. These findings underline the idea that MetS may involve disruption of endocrine-immune regulation. (c) 2020 Asia Oceania Association for the Study of Obesity. Published by Elsevier Ltd. All rights reserved.
C1 [Mauss, Daniel; Herr, Raphael M.; Fischer, Joachim E.] Heidelberg Univ, Med Fac Mannheim, Mannheim Inst Publ Hlth Social & Prevent Med, Ludolf Krehl Str 7, D-68167 Mannheim, Germany.
   [Jarczok, Marc N.] Ulm Univ, Clin Psychosomat Med & Psychotherapy, Albert Einstein Allee 23, D-89081 Ulm, Germany.
   [Motoc, Irina] Univ Amsterdam, Amsterdam Publ Hlth Res Inst, Dept Epidemiol & Biostat, Boelelaan 1117, Amsterdam, Netherlands.
   [Bosch, A.] Univ Amsterdam, Dept Clin Psychol, Postbus 15933, NL-1001 NK Amsterdam, Netherlands.
C3 Ruprecht Karls University Heidelberg; Ulm University; University of
   Amsterdam; University of Amsterdam
RP Mauss, D (corresponding author), Heidelberg Univ, Med Fac Mannheim, Mannheim Inst Publ Hlth Social & Prevent Med, Ludolf Krehl Str 7, D-68167 Mannheim, Germany.
EM dmousetrap@googlemail.com; raphael.herr@medma.uni-heidelberg.de;
   marc.jarczok@uniklinik-ulm.de; i.motoc@amsterdamumc.nl;
   joachim.fischer@medma.uni-heidelberg.de; J.A.Bosch@uva.nl
RI Herr, Raphael/GYU-5115-2022; Jarczok, Marc N./A-2383-2014
OI Motoc, Irina/0000-0002-0046-7837; Jarczok, Marc N./0000-0002-6055-385X
CR [Anonymous], 1993, How to detect and handle outliers
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NR 36
TC 5
Z9 5
U1 0
U2 4
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1871-403X
EI 1878-0318
J9 OBES RES CLIN PRACT
JI Obes. Res. Clin. Pract.
PD JAN-FEB
PY 2021
VL 15
IS 1
BP 78
EP 84
DI 10.1016/j.orcp.2020.12.003
EA FEB 2021
PG 7
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA RB1JY
UT WOS:000631873900013
PM 33371996
DA 2025-06-11
ER

PT J
AU Kara, E
   Kahraman, E
   Dayar, E
   Anacak, GY
   Demir, O
   Gidener, S
   Atabey, N
   Durmus, N
AF Kara, Erkan
   Kahraman, Erkan
   Dayar, Ezgi
   Anacak, Gunay Yetik
   Demir, Omer
   Gidener, Sedef
   Atabey, Nese
   Durmus, Nergiz
TI The role of resistin on metabolic syndrome-induced erectile dysfunction
   and the possible therapeutic effect of Boldine
SO ANDROLOGY
LA English
DT Article
DE metabolic syndrome; erectile dysfunction; resistin; nitric oxide;
   Boldine
ID IMPROVES ENDOTHELIAL FUNCTION; NITRIC-OXIDE SYNTHASE; INSULIN
   SENSITIVITY; OXIDATIVE STRESS; OBESITY; ANTIOXIDANT; PREVALENCE;
   ADIPOKINES; PROTECTS; FRUCTOSE
AB Background Resistin is known as a potential mediator of obesity-associated insulin resistance. The high resistin level disrupts nitric oxide (NO)-mediated relaxation which is also important in erectile function. An antioxidant alkaloid, Boldine, is known as anti-diabetic and protects endothelial functions. Objectives We aimed to investigate resistin expression in penile tissue in the presence of insulin resistance (IR) and the effect of Boldine treatment on erectile functions in the metabolic syndrome (MetS) rat model. Materials and methods Wistar rats were randomly divided into three groups: Control, MetS, and boldine treated MetS group. MetS parameters were assessed by serum triglycerides (TG), uric acid (UA), glucose, insulin levels, HOMA index, and waist circumference (WC)/tibia length (TL) ratio. To evaluate erectile functions, intracavernous pressure (ICP)/mean arterial pressure (MAP) ratio was performed during cavernous nerve stimulation. Protein expressions of resistin, endothelial nitric oxide synthase (eNOS), p(S1177) eNOS, and insulin receptor-beta were evaluated by Western blotting. Results TG, glucose, insulin levels, weight, WC/TL ratio, HOMA index and resistin expression in penile tissue were significantly increased and ICP/MAP values, and p (S1177) eNOS expression in penile tissue were decreased in MetS group. Boldine treatment enhanced ICP/MAP values, insulin receptor-beta and p(S1177) eNOS expressions compared with the MetS group. Discussion and Conclusion MetS caused a deterioration in erectile function accompanied by an increase in resistin expression and a reduction in eNOS enzyme activation in the rat penile tissues. Boldine treatment resulted in an improvement in erectile function, independent of resistin expression.
C1 [Kara, Erkan; Dayar, Ezgi; Gidener, Sedef; Durmus, Nergiz] Dokuz Eylul Univ, Fac Med, Dept Pharmacol, Izmir, Turkey.
   [Kahraman, Erkan; Atabey, Nese] Izmir Biomed & Genome Ctr, Izmir, Turkey.
   [Anacak, Gunay Yetik] Ege Univ, Fac Parmacy, Dept Pharmacol, Izmir, Turkey.
   [Demir, Omer] Dokuz Eylul Univ, Fac Med, Dept Urol, Izmir, Turkey.
C3 Dokuz Eylul University; Izmir Biomedicine & Genome Center; Ege
   University; Dokuz Eylul University
RP Durmus, N (corresponding author), Dokuz Eylul Univ, Fac Med, Dept Pharmacol, Izmir, Turkey.
EM nergiz.durmus@deu.edu.tr
RI Şaman, Ezgi/GRO-3500-2022; gidener, sedef/NJS-8676-2025; Kahraman,
   Erkan/AAE-6696-2019; Yetik Anacak, Gunay/A-1418-2018; Atabey,
   Nese/A-1853-2018; Durmus, Nergiz/KAM-1185-2024
OI Yetik Anacak, Gunay/0000-0002-7788-1657; Atabey,
   Nese/0000-0003-4966-2980; Saman, Ezgi/0000-0001-5567-1408; Durmus,
   Nergiz/0000-0003-4739-9154; Kahraman, Erkan/0000-0003-0051-416X;
   GIDENER, SEDEF/0000-0002-5182-9789
FU Scientific and Technological Research Council of Turkey [114S792]
FX Scientific and Technological Research Council of Turkey, Grant/Award
   Number: 114S792
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NR 45
TC 9
Z9 10
U1 0
U2 21
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2047-2919
EI 2047-2927
J9 ANDROLOGY-US
JI Andrology
PD NOV
PY 2020
VL 8
IS 6
BP 1728
EP 1735
DI 10.1111/andr.12853
EA AUG 2020
PG 8
WC Andrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA ON9KM
UT WOS:000555688800001
PM 32609430
OA Bronze
DA 2025-06-11
ER

PT J
AU Buquicchio, R
   Foti, C
   Loconsole, F
   Polimeno, L
   Ventura, MT
AF Buquicchio, R.
   Foti, C.
   Loconsole, F.
   Polimeno, L.
   Ventura, M. T.
TI CLUSTERIN SERUM LEVEL: HOW DOES IT AFFECT PSORIATIC PATIENTS?
SO JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
LA English
DT Article
DE clusterin; metabolic syndrome; psoriasis
ID KAPPA-B; PROTEIN; DISEASE
AB Psoriasis is a chronic inflammatory skin disease with systemic involvement that might predispose to many psoriasis-related comorbidities, such as metabolic syndrome and cardiovascular disorders. Clusterin (Clu), also known as apolipoprotein J (ApoJ), is a highly conserved disulfide-linked heterodimeric glycoprotein implicated in a great variety of physiological and pathophysiological processes including lipid transportation, tissue remodeling, senescence, cell interaction, stress response, inflammation, apoptosis, diabetes mellitus and metabolic syndrome. Serum levels of Clu were assessed in 15 patients with moderate-to-severe psoriasis defined by the presence of a Psoriasis Area and a Severity Index (PASI) value of 10 or more. It was found that the Clu value was significantly higher in patients than in healthy subjects (p <0.001). Our data confirm that the association of psoriatic disease with some comorbidities, especially metabolic and cardiovascular disease, might support the correlation with increased circulating Clu. In particular, it should be pointed out that, according to the recent literature, the Clu could also have a protective role in the comorbidity of psoriasis patients. In addition, it has been published that Clu protects cardiomyocytes against ischemic cell death and is a potential therapeutic agent in the treatment of myocardial infarction; therefore it can be assumed that an artificial enhancement of Clu in the blood could limit the severity of damage also in respect to skin lesions. Although the increase in serum level of Clu was found in all patients with psoriasis, more studies on a larger cohort of patient samples is necessary to confirm the significance of high serum levels of clusterin/ApoJ and to suggest the use of this glycoprotein as an additional new marker in psoriasis pathogenesis. It could be a possibility to improve the prognosis in patients with psoriasis.
C1 [Buquicchio, R.; Foti, C.; Loconsole, F.] Univ Bari, Sch Med, Dept Biomed Sci & Human Oncol, Dermatol Clin, Bari, Italy.
   [Polimeno, L.] Univ Bari, Sch Med, Dept Interdisciplinary Med, Sect Sci & Technol Lab Med, Bari, Italy.
   [Ventura, M. T.] Univ Bari, Sch Med, Dept Interdisciplinary Med, Bari, Italy.
C3 Universita degli Studi di Bari Aldo Moro; Universita degli Studi di Bari
   Aldo Moro; Universita degli Studi di Bari Aldo Moro
RP Ventura, MT (corresponding author), Univ Bari, Dept Interdisciplinary Med, Piazza G Cesare 11, I-70124 Bari, Italy.
EM mariateresa.ventura@uniba.it
RI Ventura, Maria/J-8197-2017; buquicchio, rosalba/AAB-9911-2022
OI LOCONSOLE, Francesco/0000-0003-2852-9451; VENTURA, Maria
   Teresa/0000-0002-2637-4583
CR Aronis KN, 2011, METABOLISM, V60, P747, DOI 10.1016/j.metabol.2010.12.013
   Ataseven A, 2014, DIS MARKERS, V2014, DOI 10.1155/2014/541709
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   Jabbari A, 2011, GIORN ITAL DERMAT V, V146, P17
   Kurylowicz A, 2008, ACTA BIOCHIM POL, V55, P629
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NR 15
TC 8
Z9 8
U1 0
U2 3
PU BIOLIFE SAS
PI SILVA MARINA (TE)
PA VIA S STEFANO 39 BIS, 64029 SILVA MARINA (TE), ITALY
SN 0393-974X
EI 1724-6083
J9 J BIOL REG HOMEOS AG
JI J. Biol. Regul. Homeost. Agents
PD JUL-SEP
PY 2017
VL 31
IS 3
BP 785
EP 789
PG 5
WC Endocrinology & Metabolism; Immunology; Medicine, Research &
   Experimental; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Immunology; Research & Experimental
   Medicine; Physiology
GA FJ4EE
UT WOS:000412687500034
PM 28958138
DA 2025-06-11
ER

PT J
AU Zawieja, SD
   Gasheva, O
   Zawieja, DC
   Muthuchamy, M
AF Zawieja, Scott D.
   Gasheva, Olga
   Zawieja, David C.
   Muthuchamy, Mariappan
TI Blunted flow-mediated responses and diminished nitric oxide synthase
   expression in lymphatic thoracic ducts of a rat model of metabolic
   syndrome
SO AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
LA English
DT Article
DE metabolic syndrome; lymphatic vessel contraction; lymph flow; nitric
   oxide synthase; lymphatic endothelial cells
ID ENDOTHELIUM-DEPENDENT RELAXATION; MASSIVE LOCALIZED LYMPHEDEMA;
   INCREASED OXIDATIVE STRESS; MESENTERIC LYMPHATICS; INSULIN-RESISTANCE;
   CONTRACTILE ACTIVITY; VESSELS; OBESITY; PUMP; INFLAMMATION
AB Shear-dependent inhibition of lymphatic thoracic duct (TD) contractility is principally mediated by nitric oxide (NO). Endothelial dysfunction and poor NO bioavailability are hallmarks of vasculature dysfunction in states of insulin resistance and metabolic syndrome (MetSyn). We tested the hypothesis that flow-dependent regulation of lymphatic contractility is impaired under conditions of MetSyn. We utilized a 7-wk high-fructose-fed male Sprague-Dawley rat model of MetSyn and determined the stretch-and flow-dependent contractile responses in an isobaric ex vivo TD preparation. TD diameters were tracked and contractile parameters were determined in response to different transmural pressures, imposed flow, exogenous NO stimulation by S-nitro-N-acetylpenicillamine (SNAP), and inhibition of NO synthase (NOS) by L-nitro-arginine methyl ester (L-NAME) and the reactive oxygen species (ROS) scavenging molecule 4-hydroxytempo (tempol). Expression of endothelial NO synthase (eNOS) in TD was determined using Western blot. Approximately 25% of the normal flow-mediated inhibition of contraction frequency was lost in TDs isolated from MetSyn rats despite a comparable SNAP response. Inhibition of NOS with L-NAME abolished the differences in the shear-dependent contraction frequency regulation between control and MetSyn TDs, whereas tempol did not restore the flow responses in MetSyn TDs. We found a significant reduction in eNOS expression in MetSyn TDs suggesting that diminished NO production is partially responsible for impaired flow response. Thus our data provide the first evidence that MetSyn conditions diminish eNOS expression in TD endothelium, thereby affecting the flow-mediated changes in TD lymphatic function.
C1 [Zawieja, Scott D.; Gasheva, Olga; Zawieja, David C.; Muthuchamy, Mariappan] Texas A&M Univ, Texas A&M Hlth Sci Ctr, Div Lymphat Biol, Dept Med Physiol,Coll Med,Cardiovasc Res Inst, 702 SW HK Dodgen Loop, Temple, TX 76504 USA.
C3 Texas A&M University System; Texas A&M University College Station; Texas
   A&M Health Science Center
RP Muthuchamy, M (corresponding author), Texas A&M Univ, Texas A&M Hlth Sci Ctr, Div Lymphat Biol, Dept Med Physiol,Coll Med,Cardiovasc Res Inst, 702 SW HK Dodgen Loop, Temple, TX 76504 USA.
EM marim@tamu.edu
OI Zawieja, David/0000-0002-2644-6524
FU National Institute of Diabetes and Digestive and Kidney Diseases
   [R01-DK-99221]
FX This work was supported by National Institute of Diabetes and Digestive
   and Kidney Diseases Grant R01-DK-99221 (to M. Muthuchamy and D. C.
   Zawieja).
CR Ahmed RL, 2011, BREAST CANCER RES TR, V130, P981, DOI 10.1007/s10549-011-1667-z
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NR 49
TC 29
Z9 31
U1 0
U2 6
PU AMER PHYSIOLOGICAL SOC
PI Rockville
PA 6120 Executive Blvd, Suite 600, Rockville, MD, UNITED STATES
SN 0363-6135
EI 1522-1539
J9 AM J PHYSIOL-HEART C
JI Am. J. Physiol.-Heart Circul. Physiol.
PD FEB 1
PY 2016
VL 310
IS 3
BP H385
EP H393
DI 10.1152/ajpheart.00664.2015
PG 9
WC Cardiac & Cardiovascular Systems; Physiology; Peripheral Vascular
   Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Physiology
GA DC2PC
UT WOS:000369057600007
PM 26637560
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU El-Bassossy, HM
   Dsokey, N
   Fahmy, A
AF El-Bassossy, Hany M.
   Dsokey, Nora
   Fahmy, Ahmed
TI Characterization of vascular complications in experimental model of
   fructose-induced metabolic syndrome
SO TOXICOLOGY MECHANISMS AND METHODS
LA English
DT Article
DE Aorta; hypertension; metabolic syndrome; vascular reactivity; rat
ID INHIBITION ALLEVIATES HYPERTENSION; INSULIN-RESISTANCE; ENDOTHELIAL
   DYSFUNCTION; DEPENDENT RELAXATION; CARDIOVASCULAR RISK; OXIDATIVE
   STRESS; ANGIOTENSIN-II; YOUNG SUBJECTS; RATS; RESPONSES
AB Vascular dysfunction is an important complication associated with metabolic syndrome (MS). Here we fully characterized vascular complications in a rat model of fructose-induced MS. MS was induced by adding fructose (10%) to drinking water to male Wistar rats of 6 weeks age. Blood pressure (BP) and isolated aorta responses phenylephrine (PE), KCl, acetylcholine (ACh), and sodium nitroprusside (SNP) were recorded after 6, 9, and 12 weeks of fructose administration. In addition, serum levels of glucose, insulin, uric acid, tumor necrosis factor a (TNF alpha), lipids, advanced glycation end products (AGEs), and arginase activity were determined. Furthermore, aortic reactive oxygen species (ROS) generation, hemeoxygenase-1 expression, and collagen deposition were examined. Fructose administration resulted in a significant hyperinslinemia after 6 weeks which continued for 12 weeks. It was also associated with a significant increase in BP after 6 weeks which was stable for 12 weeks. Aorta isolated from MS animals showed exaggerated contractility to PE and KCl and impaired relaxation to ACh compared with control after 6 weeks which were clearer at 12 weeks of fructose administration. In addition, MS animals showed significant increases in serum levels of lipids, uric acid, AGEs, TNFa, and arginase enzyme activity after 12 weeks of fructose administration. Furthermore, aortae isolated from MS animals were characterized by increased ROS generation and collagen deposition. In conclusion, adding fructose (10%) to drinking water produces a model of MS with vascular complications after 12 weeks that are characterized by insulin resistance, hypertension, disturbed vascular reactivity and structure, hyperuricemia, dyslipidemia, and low-grade inflammation.
C1 [El-Bassossy, Hany M.] King Abdulaziz Univ, Fac Pharm, Dept Pharmacol, Jeddah 21589, Saudi Arabia.
   [El-Bassossy, Hany M.; Dsokey, Nora; Fahmy, Ahmed] Zagazig Univ, Fac Pharm, Dept Pharmacol, Zagazig, Egypt.
C3 King Abdulaziz University; Egyptian Knowledge Bank (EKB); Zagazig
   University
RP El-Bassossy, HM (corresponding author), King Abdulaziz Univ, Fac Pharm, Dept Pharmacol, POB 80260, Jeddah 21589, Saudi Arabia.
EM helbassossy@kau.edu.sa
RI El-Bassossy, Hany/NKQ-3705-2025; El-Bassossy, Hany/I-1576-2012
OI El-Bassossy, Hany/0000-0002-6838-6945
FU Science and Technology Development Fund, Egypt [ID1024]
FX The authors state that they have no declaration of interest. This work
   is funded by a research Grant ID1024 provided by the Science and
   Technology Development Fund, Egypt.
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NR 55
TC 32
Z9 35
U1 0
U2 5
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1537-6516
EI 1537-6524
J9 TOXICOL MECH METHOD
JI Toxicol. Mech. Methods
PD DEC
PY 2014
VL 24
IS 8
BP 536
EP 543
DI 10.3109/15376516.2014.945109
PG 8
WC Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Toxicology
GA AS6GU
UT WOS:000344363200002
PM 25046175
DA 2025-06-11
ER

PT J
AU Sengul, C
   Duman, D
AF Sengul, Cihan
   Duman, Dursun
TI The Association of Epicardial Fat Thickness with Blunted Heart Rate
   Recovery in Patients with Metabolic Syndrome
SO TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE
LA English
DT Article
DE cardiac stress test; echocardiography; epicardial fat; heart rate
   recovery; metabolic syndrome
ID ENDOTHELIUM-DEPENDENT DILATION; ADIPOSE-TISSUE; SYMPATHETIC ACTIVATION;
   RISK-FACTORS; EXERCISE; DYSFUNCTION; PREDICTOR; EVENTS; VOLUME
AB Epicardial fat tissue has unique endocrine and paracrine functions that affect the cardiac autonomic system. Epicardial fat thickness (EFT) and blunted heart rate recovery (HRR) are newly identified cardiovascular risk factors in patients with metabolic syndrome (MS). The objective of this study is to evaluate the association between EFT and HRR in patients with MS. Forty patients with MS and 36 healthy controls were included in the study. Echocardiographic EFT and HRR at 1min after exercise termination (HRR-1) are measured and compared between the two groups. HRR-1 equal to or lower than 18 beats is considered as blunted HRR. EFT was increased (7.2 +/- 2 vs. 5.6 +/- 1.8 mm; p = 0.001) and HRR-1 was significantly reduced in patients with MS compared to control group (21 +/- 8 vs. 26 +/- 9; p = 0.006). Among the MS patients, subjects with blunted HRR had increased EFT compared to patients without blunted HRR (8.5 +/- 2.0 vs. 5.9 +/- 1.1 mm, p < 0.001). In multivariate analysis, EFT was the only independent predictor of blunted HRR in patients with MS (95% confidence interval = 1.42-3.87, OR = 2.34, p = 0.001). Furthermore, EFT of equal to or thicker than 5.5 mm was associated with the blunted HRR with 84% sensitivity and 52% specificity (ROC area under curve: 0.84, 95% confidence interval = 0.70-0.96, p < 0.001). In conclusion, EFT is an independent predictor of blunted HRR, a novel cardiovascular risk factor, in patients with MS.
C1 [Sengul, Cihan] Goztepe Med Pk Hosp, Dept Cardiol, TR-34220 Istanbul, Turkey.
   [Duman, Dursun] Medipol Univ Med, Dept Cardiol, Istanbul, Turkey.
C3 Medical Park Hospitals Group; Istanbul Medipol University
RP Sengul, C (corresponding author), Goztepe Med Pk Hosp, Dept Cardiol, TR-34220 Istanbul, Turkey.
EM drcsengul@yahoo.com
RI Duman, Dursun/B-5558-2015
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NR 27
TC 22
Z9 22
U1 0
U2 0
PU TOHOKU UNIV MEDICAL PRESS
PI SENDAI
PA 2-1, SEIRYO-MACHI, AOBA-KU, SENDAI, MIYAGI 980-8575, JAPAN
SN 0040-8727
EI 1349-3329
J9 TOHOKU J EXP MED
JI Tohoku J. Exp. Med.
PD AUG
PY 2011
VL 224
IS 4
BP 257
EP 262
DI 10.1620/tjem.224.257
PG 6
WC Medicine, General & Internal; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Research & Experimental Medicine
GA 812ED
UT WOS:000294273000003
PM 21737994
OA Bronze
DA 2025-06-11
ER

PT J
AU Kawamoto, R
   Kohara, K
   Tabara, Y
   Miki, T
   Otsuka, N
AF Kawamoto, Ryuichi
   Kohara, Katsuhiko
   Tabara, Yasuharu
   Miki, Tetsuro
   Otsuka, Nobuyuki
TI Serum Gamma-Glutamyl Transferase Levels are Associated with Metabolic
   Syndrome in Community-Dwelling Individuals
SO JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
LA English
DT Article
DE Gamma-glutamyl transferase; Metabolic syndrome; Risk factor; Insulin
   resistance
ID MIDDLE-AGED MEN; CARDIOVASCULAR-DISEASE; INSULIN-RESISTANCE;
   TRANSPEPTIDASE; RISK; ATHEROSCLEROSIS; PREDICTOR; HYPERTENSION;
   MORTALITY; OXIDATION
AB Aim: Serum gamma-glutamyl transferase (GGT) activity changes in response to oxidative stress. Metabolic syndrome (MetS) is associated with an increased risk of major cardiovascular events. Few data are available on the association between serum GGT and the prevalence of MetS among community-dwelling individuals in Japan.
   Methods: We recruited 793 men (mean age, 60 +/- 14 years), and 1,073 women (62 +/- 12 years), free from any history relating to cardiovascular disease during their annual health examination, from a single community. We performed a cross-sectional study to examine whether serum GGT was associated with MetS.
   Results: The levels of most confounding characteristics varied with increasing GGT activity After adjustment for age, smoking status, drinking status, low-density lipoprotein cholesterol, uric acid, estimated glomerular filtration rate and alanine aminotransferase, the odds ratios (95% confidence interval) for MetS increased across serum GGT tertiles (1, 2.23 (1.22-4.07), and 2.32 (1.18-4.56) in men; and 1, 1.43 (0.81-2.51), and 2.64 (1.50-4.64) in women). After additional adjustment for insulin resistance markers (immuno-reactive insulin or homoeostasis model assessment of insulin resistance index), the association was attenuated and the linear relation no longer significant in both genders. Furthermore, serum GGT was significantly associated with the presence of individual components of MetS in both genders, except for dyslipidemia in men and hypertension in women.
   Conclusions: These results suggested that higher serum GGT was significantly associated with MetS and its components in the general population. This association was related with insulin resistance but was independent of other confounding factors.
C1 [Kawamoto, Ryuichi; Otsuka, Nobuyuki] Seiyo Municipal Nomura Hosp, Dept Internal Med, Seiyo City, Ehime 7971212, Japan.
   [Kohara, Katsuhiko; Tabara, Yasuharu; Miki, Tetsuro] Ehime Univ, Sch Med, Dept Geriatr Med, Matsuyama, Ehime 790, Japan.
C3 Ehime University
RP Kawamoto, R (corresponding author), Seiyo Municipal Nomura Hosp, Dept Internal Med, 9-53 Nomura,Nomura Cho, Seiyo City, Ehime 7971212, Japan.
EM rykawamo@yahoo.co.jp
FU Foundation for the Development of Community
FX This work was supported in part by a grant-in-aid from the Foundation
   for the Development of Community (2008).
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NR 35
TC 30
Z9 32
U1 0
U2 5
PU JAPAN ATHEROSCLEROSIS SOC
PI TOKYO
PA NICHINAI-KAIKAN B1, 3-28-8 HONGO BUNKYO-KU, TOKYO, 113-0033, JAPAN
SN 1340-3478
EI 1880-3873
J9 J ATHEROSCLER THROMB
JI J. Atheroscler. Thromb.
PY 2009
VL 16
IS 4
BP 355
EP 362
DI 10.5551/jat.No414
PG 8
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 493RF
UT WOS:000269754900006
PM 19755788
OA hybrid
DA 2025-06-11
ER

PT J
AU Ueba, T
   Haze, T
   Sugiyama, M
   Higuchi, M
   Asayama, H
   Karitani, Y
   Nishikawa, T
   Yamashita, K
   Nagami, S
   Nakayama, T
   Kanatani, K
   Nomura, S
AF Ueba, Tetsuya
   Haze, Takane
   Sugiyama, Masaki
   Higuchi, Mami
   Asayama, Hitoshi
   Karitani, Yoshihiro
   Nishikawa, Tomofumi
   Yamashita, Kohsuke
   Nagami, Shuhei
   Nakayama, Takeo
   Kanatani, Kazushi
   Nomura, Shosaku
TI Level, distribution and correlates of platelet-derived microparticles in
   healthy individuals with special reference to the metabolic syndrome
SO THROMBOSIS AND HAEMOSTASIS
LA English
DT Article
DE atherothrombosis; platelet-derived microparticle; metabolic syndrome
ID TRANSIENT ISCHEMIC ATTACKS; REMNANT-LIKE PARTICLE; HIGH-SHEAR-STRESS;
   ENDOTHELIAL MICROPARTICLES; CELLULAR MICROPARTICLES;
   CARDIOVASCULAR-DISEASE; HYPERTENSIVE PATIENTS; PROCOAGULANT ACTIVITY;
   ENZYME-IMMUNOASSAY; ACTIVATION
AB Platelet-derived microparticles (PDMPs), a procoagulant factor, are reportedly elevated in type 2 diabetes mellitus and acute coronary syndrome. The metabolic syndrome (MS) is strongly associated with cardio- and cerebrovascular disease-related atherothrombotic events. To clarify the level, distribution and correlates of PDMPs with special reference to MS, we conducted a cross-sectional study of 467 healthy Japanese volunteers without signs, symptoms, or a history of cardio- or cerebrovascular disease. They were 211 men and 256 women (median age 39 and 35 years, respectively). Using an ELISA kit and monoclonal antibodies against CD42b and CD42a (glycoprotein Ib and IX) we assayed the PDMP levels. Total cholesterol, low-density and high-density lipoprotein cholesterol, remnant cholesterol, triglycerides,C-reactive protein, and traditional cardiovascular risk factors were also recorded. There was a significant difference in the level of PDMPs between men and women. The median value and the interquartile range of PDMPs was 8.3 IU/ml and 6.2 - 10.5 IU/ml and 6.8 IU/ml and 5.2 - 8.6 IU/ml, respectively, in men and women. PDMPs were significantly associated with MS criteria in men (p < 0.001) and women (p=0.040). Logistic regression analysis revealed a significant odds ratio of 3.9 [95% confidence interval (0): 1.4-10.5] in men and of 4.2 [95% CI: 1.6-10.71 in the entire study population. Our results suggest that PDMPs identified by glycoprotein CD42b and CD42a are positively associated with MS.
C1 [Ueba, Tetsuya; Nishikawa, Tomofumi; Yamashita, Kohsuke] Kishiwada City Hosp, Dept Neurosurg, Kishiwada 5968501, Japan.
   [Haze, Takane; Sugiyama, Masaki; Higuchi, Mami; Asayama, Hitoshi] Kishiwada City Hosp, Dept Clin Lab, Kishiwada 5968501, Japan.
   [Karitani, Yoshihiro] Kishiwada City Hosp, Dept Pharm, Kishiwada 5968501, Japan.
   [Nagami, Shuhei] Kishiwada City Hosp, Dept Neurol, Kishiwada 5968501, Japan.
   [Nomura, Shosaku] Kishiwada City Hosp, Dept Hematol, Kishiwada 5968501, Japan.
   [Nakayama, Takeo] Kyoto Univ, Sch Publ Hlth, Dept Hlth Informat, Kyoto, Japan.
   [Kanatani, Kazushi] JIMRO Co Ltd, Diagnost Revis, Gunma, Japan.
C3 Kyoto University
RP Ueba, T (corresponding author), Kishiwada City Hosp, Dept Neurosurg, 1001 Gakuharachou, Kishiwada 5968501, Japan.
EM tueba@kuhp.kyoto-u.ac.jp
RI Ueba, Tetsuya/AFL-6434-2022; NAKAYAMA, Takeo/HCH-0537-2022
OI Nakayama, Takeo/0000-0002-7918-6252
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NR 44
TC 55
Z9 58
U1 0
U2 4
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0340-6245
EI 2567-689X
J9 THROMB HAEMOSTASIS
JI Thromb. Haemost.
PD AUG
PY 2008
VL 100
IS 2
BP 280
EP 285
DI 10.1160/TH07-11-0668
PG 6
WC Hematology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Hematology; Cardiovascular System & Cardiology
GA 337SL
UT WOS:000258455700018
PM 18690348
DA 2025-06-11
ER

PT J
AU Tsai, JCR
   Sheu, SH
   Chiu, HC
   Chung, FM
   Chang, DM
   Chen, MP
   Shin, SJ
   Lee, YJ
AF Tsai, Jack C. -R.
   Sheu, Sheng-Hsiung
   Chiu, Herng-Chia
   Chung, Fu-Mei
   Chang, Dao-Ming
   Chen, Miao-Pei
   Shin, Shyi-Jang
   Lee, Yau-Jiunn
TI Association of peripheral total and differential leukocyte counts with
   metabolic syndrome and risk of ischemic cardiovascular diseases in
   patients with type 2 diabetes mellitus
SO DIABETES-METABOLISM RESEARCH AND REVIEWS
LA English
DT Article
DE monocytes; neutrophil; lymphocyte; metabolic syndrome; atherosclerosis
ID BLOOD-CELL COUNT; CORONARY-HEART-DISEASE; LYMPHOCYTE CONCENTRATION;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; GLUCOSE; LEPTIN; ATHEROSCLEROSIS;
   INFLAMMATION; EXPRESSION
AB Background There is increasing evidence that leukocytes play a central role in obesity, glucose intolerance, type 2 diabetes mellitus (T2DM), and cardiovascular diseases, but the role of differential leukocytes in metabolic syndrome (MetS) and atherosclerosis is largely unknown. The aim of this study was to examine the relationship between the component features of MetS and peripheral leukocyte counts and to explore whether leukocyte counts are associated with clustering of MetS and macrovascular diseases in patients with T2DM.
   Methods 1872 subjects with T2DM who enrolled in a diabetes disease management program were studied. The definition of MetS was modified from that outlined by the criteria of NCEP-ATP III. Areas under the receiveroperating characteristic curve and odds ratios at various intervals of the WBC counts were computed.
   Results The peripheral total leukocyte, monocyte, and neutrophil cell counts are increased parallel to the clustering of components of MetS. When white cell counts were analyzed per quartile and as continuous variables after adjustment for age, sex, and other known risk factors with multiple regression analysis, peripheral total leukocyte, monocyte, neutrophils, and lymphocyte counts were independently and significantly associated with specific features of clustering of MetS and prevalence of ischemic cardiovascular diseases. Leukocyte counts, especially neutrophil/lymphocyte ratio, in addition with MetS is associated with the risk of ischemic cardiovascular diseases.
   Conclusion Our results indicate that differential leukocyte counts are associated with MetS and that peripheral leukocytes may play a role in the pathogenesis of macrovascular complications in patients with T2DM. Copyright (c) 2006 John Wiley & Sons, Ltd.
C1 Pingtung Christian Hosp, Dept Clin Res, Pingtung 90000, Taiwan.
   Kaohsiung Med Univ, Grad Inst Med, Kaohsiung 80307, Taiwan.
C3 Kaohsiung Medical University
RP Lee, YJ (corresponding author), Pingtung Christian Hosp, Dept Clin Res, 60 Da Lien Rd, Pingtung 90000, Taiwan.
EM t3275@ms25.hinet.net
RI Shin, Shyi-Jang/A-1523-2010; Sheu, Sheng-Hsiung/C-7445-2009; Chiu,
   Herng-Chia/D-4490-2009
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NR 50
TC 84
Z9 94
U1 0
U2 11
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1520-7552
EI 1520-7560
J9 DIABETES-METAB RES
JI Diabetes-Metab. Res. Rev.
PD FEB
PY 2007
VL 23
IS 2
BP 111
EP 118
DI 10.1002/dmrr.647
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 141LL
UT WOS:000244579900004
PM 16703635
DA 2025-06-11
ER

PT J
AU Lehto, SM
   Hintikka, J
   Niskanen, L
   Tolmunen, T
   Koivumaa-Honkanen, H
   Honkalampi, K
   Viinamäki, H
AF Lehto, Soili M.
   Hintikka, Jukka
   Niskanen, Leo
   Tolmunen, Tommi
   Koivumaa-Honkanen, Heli
   Honkalampi, Kirsi
   Viinamaki, Heimo
TI Low HDL cholesterol associates with major depression in a sample with a
   7-year history of depressive symptoms
SO PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
LA English
DT Review
DE atherogenesis; cholesterol; coronary heart disease; high-density
   lipoprotein cholesterol; major depression
ID DENSITY-LIPOPROTEIN CHOLESTEROL; POLYUNSATURATED FATTY-ACIDS;
   SERUM-LIPID CONCENTRATIONS; CHRONIC-FATIGUE-SYNDROME; METABOLIC
   SYNDROME; PLASMA; MEN; SUBTYPES; DISEASE; BINDING
AB Long-term depression may increase the risk for adverse coronary events. Low levels of high-density lipoprotein cholesterol (HDL-C) have in particular been suggested to underlie this connection. A total of 124 participants with a recorded seven-year history of depressive symptoms (depressed, n=63)or euthymic state (controls, n=61) underwent a Structured Clinical Interview for DSM-IV to confirm their psychiatric diagnosis. Total cholesterol (TC), HDL-C and low-density lipoprotein cholesterol (LDL-C) levels, triglycerides, non-HDL-C and atherogenic indices (LDL-C/HDL-C and TC/HDL-C) were assessed. The HDL-C levels were lower and atherogenic indices higher in the depressed group compared with the controls. Furthermore, those with HDL-C level below the gender-adjusted median (< 1.54 mmol/l in women, <1.16 mmol/l in men) were 2.4-fold more likely to be depressed in a model adjusting for age and non-HDL-C (p=0.019). After further adjustment for educational level, marital status, alcohol use. daily smoking and overweight this association remained significant (p=0.049). These findings suggest that compared with the healthy controls, those with long-term depression may have lower HDL-C values and higher atherogenic indices. (C) 2008 Elsevier Inc. All rights reserved.
C1 [Lehto, Soili M.; Hintikka, Jukka; Tolmunen, Tommi; Honkalampi, Kirsi; Viinamaki, Heimo] Kuopio Univ Hosp, Dept Psychiat, SF-70210 Kuopio, Finland.
   [Lehto, Soili M.; Hintikka, Jukka; Niskanen, Leo; Tolmunen, Tommi; Honkalampi, Kirsi; Viinamaki, Heimo] Univ Kuopio, Kuopio 70210, Finland.
   [Niskanen, Leo] Kuopio Univ Hosp, Dept Med, SF-70210 Kuopio, Finland.
   [Koivumaa-Honkanen, Heli] Univ Oulu, Dept Psychiat, Rovaniemi 97140, Finland.
   [Koivumaa-Honkanen, Heli] Lapland Hosp Dist, Rovaniemi 97140, Finland.
C3 University of Eastern Finland; University of Eastern Finland Hospital;
   Kuopio University Hospital; University of Eastern Finland; University of
   Eastern Finland; University of Eastern Finland Hospital; Kuopio
   University Hospital; University of Oulu
RP Lehto, SM (corresponding author), Kuopio Univ Hosp, Dept Psychiat, SF-70210 Kuopio, Finland.
EM Soili.Lehto@kuh.fi
RI Koivumaa-Honkanen, Heli/L-1274-2015
OI Lehto, Soili/0000-0003-4324-6679
FU Kuopio University Hospital EVO; Orion-Farmos Research Foundation,
   AstraZeneca; Foundation for Psychiatric Research
FX SML was supported by Kuopio University Hospital EVO funding, the Finnish
   Graduate School of Psychiatry and grants from the Orion-Farmos Research
   Foundation, AstraZeneca and the Foundation for Psychiatric Research. The
   authors would like to thank Sari Vaisanen, Ph.D., for providing
   technical details on the laboratory methods.
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NR 50
TC 70
Z9 77
U1 0
U2 19
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0278-5846
EI 1878-4216
J9 PROG NEURO-PSYCHOPH
JI Prog. Neuro-Psychopharmacol. Biol. Psychiatry
PD AUG 1
PY 2008
VL 32
IS 6
BP 1557
EP 1561
DI 10.1016/j.pnpbp.2008.05.021
PG 5
WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA 342YJ
UT WOS:000258819200030
PM 18583011
DA 2025-06-11
ER

PT J
AU Parklak, W
   Chuljerm, H
   Kawichai, S
   Fakfum, P
   Jiraya, P
   Kijkuokool, P
   Khiaolaongam, W
   Ngamsang, P
   Ounjaijean, S
   Rerkasem, K
   Kulprachakarn, K
AF Parklak, Wason
   Chuljerm, Hataichanok
   Kawichai, Sawaeng
   Fakfum, Puriwat
   Jiraya, Putita
   Kijkuokool, Praporn
   Khiaolaongam, Wiritphon
   Ngamsang, Pakaphorn
   Ounjaijean, Sakaewan
   Rerkasem, Kittipan
   Kulprachakarn, Kanokwan
TI The Impact of Nutrition and Fine Particulate Matter (PM2.5) on
   Inflammatory Responses in Individuals with Metabolic Syndrome: A Paired
   Case Study from Chiang Mai, Thailand
SO TOXICS
LA English
DT Article
DE PM2.5; nutrition; inflammation; dietary fiber; antioxidant vitamins;
   metabolic syndrome
ID OXIDATIVE STRESS; BLOOD-PRESSURE; AIR-POLLUTION; ANTIOXIDANT; HEALTHY;
   EXPOSURE; PHYTOCHEMICALS; DISEASE; MARKERS; SODIUM
AB Exposure to fine particulate matter (PM2.5) is linked to increased systemic inflammation, particularly in individuals with metabolic syndrome (MS). This study assessed the impact of nutrition and PM2.5 exposure on inflammatory markers in individuals with MS. A total of 50 participants (25 with MS, 25 healthy controls) were monitored during a high-PM2.5 exposure period (HEP) and a low-PM2.5 exposure period (LEP). Dietary intake, health assessments, and inflammatory markers-TNF-alpha, IL-6, and CRP-were evaluated. The MS group had significantly higher BMI, fasting blood glucose, and triglyceride levels and lower HDL-C than the healthy group (p < 0.01), but these parameters did not change significantly between the HEP and LEP. Notably, dietary fiber intake increased in the MS group during the LEP (p < 0.05). CRP levels were higher in the MS group and significantly decreased in both groups during the LEP (p < 0.05). IL-6 was higher in the MS group during the HEP but did not significantly change across periods. TNF-alpha showed no differences. Dietary fiber intake was inversely correlated with IL-6 and CRP in the healthy group and strongly correlated with CRP in the MS group (r = -0.403, p < 0.01). Antioxidant vitamins were inversely correlated with inflammation only in healthy participants. These findings suggest that an increased dietary fiber intake may help reduce PM2.5-induced inflammation, particularly in individuals with MS.
C1 [Parklak, Wason; Chuljerm, Hataichanok; Kawichai, Sawaeng; Fakfum, Puriwat; Jiraya, Putita; Ounjaijean, Sakaewan; Rerkasem, Kittipan; Kulprachakarn, Kanokwan] Chiang Mai Univ, Res Inst Hlth Sci, Res Ctr Noninfect Dis & Environm Hlth, Chiang Mai 50200, Thailand.
   [Chuljerm, Hataichanok; Kijkuokool, Praporn; Khiaolaongam, Wiritphon; Ngamsang, Pakaphorn; Ounjaijean, Sakaewan; Kulprachakarn, Kanokwan] Chiang Mai Univ, Res Inst Hlth Sci, Sch Hlth Sci Res, Chiang Mai 50200, Thailand.
   [Rerkasem, Kittipan] Chiang Mai Univ, Fac Med, Clin Surg Res Ctr, Dept Surg, Chiang Mai 50200, Thailand.
C3 Chiang Mai University; Chiang Mai University; Chiang Mai University
RP Kulprachakarn, K (corresponding author), Chiang Mai Univ, Res Inst Hlth Sci, Res Ctr Noninfect Dis & Environm Hlth, Chiang Mai 50200, Thailand.; Kulprachakarn, K (corresponding author), Chiang Mai Univ, Res Inst Hlth Sci, Sch Hlth Sci Res, Chiang Mai 50200, Thailand.
EM wason.p@cmu.ac.th; hataichanok.ch@cmu.ac.th; sawaeng.kaw@cmu.ac.th;
   nuengpuriwat@gmail.com; putita_jiraya@cmu.ac.th; praporn_k@cmu.ac.th;
   wiritphon_k@cmu.ac.th; pakaporn_ng@cmu.ac.th; sakaewan.o@cmu.ac.th;
   rerkase@gmail.com; kanokwan.kul@cmu.ac.th
RI Ounjaijean, Sakaewan/GQB-2632-2022; Chuljerm, Hataichanok/HZM-0882-2023;
   Kulprachakarn, Kanokwan/P-6170-2019; Kawichai, Sawaeng/AHI-1315-2022
FU Chiang Mai University;  [PM 11/2566]
FX This research was partially supported by Chiang Mai University (grant
   number: PM 11/2566).
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NR 68
TC 0
Z9 0
U1 1
U2 1
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2305-6304
J9 TOXICS
JI Toxics
PD APR 22
PY 2025
VL 13
IS 5
AR 325
DI 10.3390/toxics13050325
PG 23
WC Environmental Sciences; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Toxicology
GA 3BE6L
UT WOS:001496170700001
PM 40423404
OA gold
DA 2025-06-11
ER

PT J
AU Zhong, Y
   Wang, TH
   Huang, LJ
   Hua, YS
AF Zhong, Yuan
   Wang, Tian-Hong
   Huang, Li-Jiang
   Hua, Yu-Si
TI Association between metabolic syndrome and the risk of Parkinson's
   disease: a meta-analysis
SO BMC NEUROLOGY
LA English
DT Review
DE Metabolic syndrome; Parkinson's disease; Risk factors; Meta-analysis
ID C-REACTIVE PROTEIN; OXIDATIVE STRESS; MARKERS; LINK
AB BackgroundThere is still a lack of knowledge about the relationship between metabolic syndrome (MetS) and Parkinson's disease (PD). This study aimed to determine whether MetS increases PD risk.MethodsTo identify relevant clinical studies, databases such as PubMed, Embase, and the Cochrane Library were searched in depth from the inception of databases until March 31, 2024. The study evaluated the correlation between MetS and the likelihood of developing PD through the computation of aggregated relative risks (RR) and their respective 95% confidence intervals (CIs) utilizing selnRR and lnRR.ResultsSeven studies were included in our systematic review. The meta-analysis revealed that patients with MetS have a 0.3-fold increased risk of developing PD (p = 0.001). Furthermore, the analysis revealed a positive correlation between central obesity and the incidence of PD, with an RR of 1.19 (95% CI, 1.16-1.22; p = 0.001), as well as a greater risk of PD in patients with elevated blood pressure, with an RR of 1.13 (95% CI, 1.07-1.19; p = 0.001); elevated serum triglyceride levels, with an RR of 1.09 (95% CI, 1.02-1.15; p = 0.001); lower serum HDL cholesterol levels, with an RR of 1.21 (95% CI, 1.15-1.28; p = 0.001); and elevated plasma fasting glucose levels, with an RR of 1.18 (95% CI, 1.11-1.26; p = 0.001).ConclusionMetS can contribute to the incidence of Parkinson's disease, with individual components of MetS demonstrating comparable effects.
C1 [Zhong, Yuan] Sichuan Univ, West China Hosp, West China Sch Nursing, Dept Anesthesiolo, Chengdu, Sichuan, Peoples R China.
   [Wang, Tian-Hong; Hua, Yu-Si] Sichuan Univ, West China Hosp, Dept Anesthesiol, Chengdu 610041, Peoples R China.
   [Huang, Li-Jiang] Chongqing Med Univ, Peoples Hosp Xiushan Cty, Dept Neurol, Chongqing, Peoples R China.
C3 Sichuan University; Sichuan University; Chongqing Medical University
RP Hua, YS (corresponding author), Sichuan Univ, West China Hosp, Dept Anesthesiol, Chengdu 610041, Peoples R China.
EM yusihua@wchscu.cn
CR Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
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NR 22
TC 2
Z9 2
U1 0
U2 2
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2377
J9 BMC NEUROL
JI BMC Neurol.
PD SEP 4
PY 2024
VL 24
IS 1
AR 313
DI 10.1186/s12883-024-03820-y
PG 8
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA E9Y1B
UT WOS:001306473700007
PM 39232681
OA gold
DA 2025-06-11
ER

PT J
AU Xu, HY
   Xu, JY
   Liu, XY
   Song, W
   Lyu, X
   Guo, XA
   Hu, WJ
   Yang, HB
   Wang, LJ
   Pan, H
   Chen, JC
   Xing, XP
   Zhu, HJ
   Sun, W
   Gong, FY
AF Xu, Hanyuan
   Xu, Jiyu
   Liu, Xiaoyan
   Song, Wei
   Lyu, Xiaorui
   Guo, Xiaonan
   Hu, Wenjing
   Yang, Hongbo
   Wang, Linjie
   Pan, Hui
   Chen, Jichun
   Xing, Xiaoping
   Zhu, Huijuan
   Sun, Wei
   Gong, Fengying
TI Serum metabolomics profiling of improved metabolic syndrome is
   characterized by decreased pro-inflammatory biomarkers: A longitudinal
   study in Chinese male adults
SO NUTRITION RESEARCH
LA English
DT Article
DE Metabolic syndrome (MetS); Metabolomics; Prostaglandin E2;
   Neuroprotectin D1; Taxiphyllin; Longitudinal study
ID CYTOKINE PRODUCTION; OBESITY; EXERCISE; DISEASE; DIET; FAT;
   CYCLOOXYGENASE-2; SUPPLEMENTATION; PGE(2); BRAIN
AB Metabolic syndrome (MetS) is a serious global health concern. The objective of this study is to dynamically investigate the changes of metabolic profiles and metabolites in Chinese male MetS subjects after an 18 months diet and exercise intervention. Fifty male MetS patients defined according to International Diabetes Federation 2005 guidelines were sub-jected to diet and exercise counseling for 18 months. Serum samples were taken at baseline, 12 months, and 18 months, respectively, for clinical evaluation and metabolomics analy- ses. Diet and exercise intervention for 18 months achieved significant improvements in the metabolic profiles of all participants. Nineteen subjects (38.0%) exhibited MetS remission at the end of the study. A total of 812 relative features were characterized and 61 were success-fully identified. Furthermore, 17 differential metabolites were of significance at both time points (baseline-12 months, baseline-18 months) and presented nonlinear trends through time. Eight metabolites (47.1%) were predominantly converged to inflammation and oxida-tive stress. Pro-inflammatory biomarkers were remarkably decreased after 18 months of in-tervention, and prostaglandin E2, neuroprotectin D1, and taxiphyllin in combination were firstly found to demonstrate a fair discriminative power (area under curve = 0.911) to predict the improvement of MetS undergone diet and exercise intervention. The significant shift of metabolomic profiling after 18 months of lifestyle counseling provide a novel insight and reveal that earlier inflammation control may be of potential benefit in MetS management.(c) 2023 Published by Elsevier Inc.
C1 [Xu, Hanyuan; Lyu, Xiaorui; Guo, Xiaonan; Hu, Wenjing; Yang, Hongbo; Wang, Linjie; Pan, Hui; Xing, Xiaoping; Zhu, Huijuan; Gong, Fengying] Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Key Lab Endocrinol, Natl Hlth Commiss,Dept Endocrinol, Beijing 100730, Peoples R China.
   [Xu, Hanyuan] Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Clin Nutr, Beijing 100730, Peoples R China.
   [Xu, Jiyu; Liu, Xiaoyan; Sun, Wei] Chinese Acad Med Sci, Peking Union Med Coll, Sch Basic Med, Inst Basic Med Sci, Beijing, Peoples R China.
   [Song, Wei] Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, State Key Lab Complex Severe & Rare Dis, Med Sci Res Ctr, Beijing 100730, Peoples R China.
   [Chen, Jichun] Chinese Acad Med Sci & Peking Union Med Coll, Fuwai Hosp, Natl Ctr Cardiovasc Dis, Nutr Dept, 167 Beilishi Rd, Beijing, Peoples R China.
C3 Chinese Academy of Medical Sciences - Peking Union Medical College;
   Peking Union Medical College; Peking Union Medical College Hospital;
   Chinese Academy of Medical Sciences - Peking Union Medical College;
   Peking Union Medical College; Peking Union Medical College Hospital;
   Chinese Academy of Medical Sciences - Peking Union Medical College;
   Peking Union Medical College; Institute of Basic Medical Sciences -
   CAMS; Chinese Academy of Medical Sciences - Peking Union Medical
   College; Peking Union Medical College Hospital; Peking Union Medical
   College; Chinese Academy of Medical Sciences - Peking Union Medical
   College; Fu Wai Hospital - CAMS; Peking Union Medical College
RP Zhu, HJ; Gong, FY (corresponding author), Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Key Lab Endocrinol, Natl Hlth Commiss,Dept Endocrinol, Beijing 100730, Peoples R China.; Sun, W (corresponding author), Chinese Acad Med Sci, Peking Union Med Coll, Sch Basic Med, Inst Basic Med Sci, Beijing, Peoples R China.
EM shengxin2004@163.com; sunwei1018@sina.com; fygong@sina.com
RI Liu, XiaoYan/GQA-7216-2022; Song, Wei/GQH-3892-2022
FU CAMS Innovation Fund for Medical Sciences (CIFMS) [2022-I2M-2-002];
   National Natural Science Foundation of China [82270913]; Beijing Natural
   Science Foundation [7222137]; National Key Technology Research and
   Development Program of China during the "11th Five-Year Plan" from the
   Ministry of Science and Technology [2006BAI01A01]; National Key Clinical
   Specialty Capacity Improvement Project; Innovation fund for postgraduate
   students of Peking Union Medical College [2019-1002-26]
FX This work was supported by the CAMS Innovation Fund for Medical Sciences
   (CIFMS) (No. 2022-I2M-2-002), the National Natural Science Foundation of
   China (No.82270913), Beijing Natural Science Foundation (No. 7222137),
   National Key Technology Research and Development Program of China during
   the "11th Five-Year Plan" from the Ministry of Science and Technology
   (2006BAI01A01), National Key Clinical Specialty Capacity Improvement
   Project, and the Innovation fund for postgraduate students of Peking
   Union Medical College (2019-1002-26).
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NR 61
TC 1
Z9 1
U1 1
U2 5
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0271-5317
EI 1879-0739
J9 NUTR RES
JI Nutr. Res.
PD JUL
PY 2023
VL 115
BP 13
EP 25
DI 10.1016/j.nutres.2023.04.006
EA MAY 2023
PG 13
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA J4JE1
UT WOS:001009284000001
PM 37216838
DA 2025-06-11
ER

PT J
AU Conde-Pipó, J
   Bouzas, C
   Mariscal-Arcas, M
   Tur, JA
AF Conde-Pipo, Javier
   Bouzas, Cristina
   Mariscal-Arcas, Miguel
   Tur, Josep A.
TI Association between Functional Fitness and Health-Related Quality of
   Life in the Balearic Islands' Old Adults with Metabolic Syndrome
SO NUTRIENTS
LA English
DT Article
DE metabolic syndrome; physical activity; fitness; quality of life; older
   adults
ID PHYSICAL-ACTIVITY; MEDITERRANEAN POPULATION; EXERCISE; ADHERENCE;
   QUESTIONNAIRES; DETERMINANTS; PREVALENCE; PROGRAMS; VALIDITY; STRESS
AB Research assessing the relationship between functional fitness (FF) and health-related quality of life (HRQoL) is still scarce. The objective of this research is to assess the association between FF and HRQoL in older adults with metabolic syndrome (MetS) from Balearic Islands (Spain). The design is a cross-sectional, descriptive, and comparative study involving 209 participants (42.2% women). The sociodemographic data and medical history of the participants were collected. Physical activity was evaluated using the Spanish version of the Rapid Assessment of Physical Activity Questionnaire. Anthropometrics and blood pressure were measured. Glucose, total cholesterol, high-density lipoprotein cholesterol, and triglyceride plasma levels were measured. A battery of functional fitness tests was applied. HRQoL was measured with the Spanish version of the SF-36 questionnaire. Adherence to the Mediterranean dietary pattern was assessed. In older subjects with MetS, a higher FF score and, within it, endurance, lower body strength, one-leg balance, and agility are positively associated with lower physical function (p < 0.001; d = 0.56), better general health (p = 0.019; d = 0.35), and better summary physical component of HRQoL (p < 0.001; d = 0.57). The FF score and HRQoL physical component are both positively associated with high levels of physical activity (ORadj = 10.3, IC 4.19-28.2, p < 0.001; ORadj = 3.25, IC 1.44-7.72, p < 0.005). Older adults with MetS should consider practicing physical activity above the general recommendations to improve their functional fitness and health status and quality of life.
C1 [Conde-Pipo, Javier] Univ Granada, Fac Educ Sci, Dept Didact Mus Plast & Corporal, Granada 18071, Spain.
   [Bouzas, Cristina; Tur, Josep A.] Univ Balearic Isl IUNICS, Res Grp Community Nutr & Oxidat Stress, Palma De Mallorca 07122, Spain.
   [Bouzas, Cristina; Tur, Josep A.] Hlth Inst Balearic Isl IDISBA, Palma De Mallorca 07120, Spain.
   [Bouzas, Cristina; Tur, Josep A.] Inst Salud Carlos III ISCIII, CIBEROBN Physiopathol Obes & Nutr CB12 03 30038, Madrid 28029, Spain.
   [Mariscal-Arcas, Miguel] Univ Granada, Sch Pharm, Dept Nutr & Food Sci, Granada 18071, Spain.
C3 University of Granada; CIBER - Centro de Investigacion Biomedica en Red;
   CIBEROBN; University of Granada
RP Tur, JA (corresponding author), Univ Balearic Isl IUNICS, Res Grp Community Nutr & Oxidat Stress, Palma De Mallorca 07122, Spain.; Tur, JA (corresponding author), Hlth Inst Balearic Isl IDISBA, Palma De Mallorca 07120, Spain.; Tur, JA (corresponding author), Inst Salud Carlos III ISCIII, CIBEROBN Physiopathol Obes & Nutr CB12 03 30038, Madrid 28029, Spain.
EM javiercondepipo@gmail.com; cristina.bouzas@uib.es; mariscal@ugr.es;
   pep.tur@uib.es
RI Bouzas, Cristina/AAE-2069-2019; Tur, Josep/AAE-5748-2020;
   Mariscal-Arcas, Miguel/R-3406-2019; Tur, Josep/F-5576-2014; Conde Pipo,
   Javier/AAH-4848-2020; Mariscal-Arcas, Miguel/K-4150-2017
OI Bouzas Velasco, Cristina/0000-0002-1407-8461; Tur,
   Josep/0000-0002-6940-0761; Conde Pipo, Javier/0000-0003-0646-4044;
   Mariscal-Arcas, Miguel/0000-0001-9852-4950
FU European Regional Development Fund [CB12/03/30038]; IdISBa grant
   (FOLIUM); IdISBa grant (PRIMUS); IdISBa grant (SYNERGIA); IdISBa grant
   (LIBERI)
FX Instituto de Salud Carlos III through CIBEROBN CB12/03/30038, which is
   cofunded by the European Regional Development Fund. Other funding
   received: IdISBa grants (FOLIUM, PRIMUS, SYNERGIA, and LIBERI). The
   funding sponsors had no role in the design of the study; in the
   collection, analyses, or interpretation of the data; in the writing of
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NR 49
TC 7
Z9 7
U1 1
U2 9
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD MAY
PY 2022
VL 14
IS 9
AR 1798
DI 10.3390/nu14091798
PG 15
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nutrition & Dietetics
GA 1E7HQ
UT WOS:000794655200001
PM 35565767
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Yao, K
   Bian, C
   Zhao, X
AF Yao, Kui
   Bian, Ce
   Zhao, Xia
TI Association of polycystic ovary syndrome with metabolic syndrome and
   gestational diabetes: Aggravated complication of pregnancy (Review)
SO EXPERIMENTAL AND THERAPEUTIC MEDICINE
LA English
DT Article
DE polycystic ovary syndrome; hyperinsulinemia; cytochrome p450-c17
   alpha-hydroxylase; functional ovarian hyperandrogenism; metabolic
   syndrome; gestational diabetes
ID INSULIN-RESISTANCE; SYNDROME PCOS; DIAGNOSTIC-CRITERIA; ANDROGEN EXCESS;
   WOMEN; HYPERANDROGENISM; PREVALENCE; METFORMIN; MELLITUS; OUTCOMES
AB Polycystic ovary syndrome (PCOS) affects 5-20% of the reproductive age women globally. PCOS is diagnosed by the presence of hyperandrogenism, oligo-anovulation, and polycystic morphology of at least one ovary. Insulin resistance (IR), hyperinsulinemia and associated metabolic abnormalities including metabolic syndrome play a significant role in the development of PCOS. The chances of developing MS in PCOS women was shown to increase by almost 14-fold in patients with increasing body mass index. Even in the absence of overt obesity, a preferential deposition of intra-abdominal fat is noted in PCOS women and this intra-abdominal fat leads to impaired insulin action and functional IR and hyperandrogenism. Functional ovarian hyperandrogenism of ovaries was suggested to be a consequence of IR, which activates androgen synthesizing enzyme, cytochrome p450-c17 alpha-hydroxylase, in ovarian theca cells and causes elevated oxidative stress accompanied by lower antioxidant status in ovaries, which contribute to PCOS pathogenesis. The elevated levels of luteinizing hormone that accompany the early stages of hyperandrogenemia, accelerate ovarian functional deterioration, which is further aggravated by hyperinsulinemia, in PCOS women. The risk of developing gestational diabetes in PCOS women is approximately three times greater, as compared to non-PCOS women, due to IR and hyperinsulinemia. Typical insulin-sensitizing drugs such as metformin, have been used to curtail IR and hyperinsulinemia in pregnant PCOS women, with varying results indicating the complexity of the disease and the need for better controlled studies and additional efforts for PCOS-specific drug discovery.
C1 [Yao, Kui; Bian, Ce; Zhao, Xia] Sichuan Univ, Minist Educ, Key Lab Birth Defects & Related Dis Women & Child, 20 Sect 3,South Renmin Rd, Chengdu 610042, Sichuan, Peoples R China.
   [Yao, Kui; Bian, Ce; Zhao, Xia] West China Second Univ Hosp, Chengdu, Sichuan, Peoples R China.
C3 Ministry of Education - China; Sichuan University
RP Zhao, X (corresponding author), Sichuan Univ, Minist Educ, Key Lab Birth Defects & Related Dis Women & Child, 20 Sect 3,South Renmin Rd, Chengdu 610042, Sichuan, Peoples R China.
EM rxbbjn@163.com
RI Yao, Kui/HGE-6416-2022
FU Scientific Research Project of Sichuan Medical Association [S16053]
FX This study was suppoted by Scientific Research Project of Sichuan
   Medical Association (S16053).
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NR 60
TC 35
Z9 45
U1 0
U2 4
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1792-0981
EI 1792-1015
J9 EXP THER MED
JI Exp. Ther. Med.
PD AUG
PY 2017
VL 14
IS 2
BP 1271
EP 1276
DI 10.3892/etm.2017.4642
PG 6
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA FB7BY
UT WOS:000406297300054
PM 28810587
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Mehran, L
   Amouzegar, A
   Rahimabad, PK
   Tohidi, M
   Tahmasebinejad, Z
   Azizi, F
AF Mehran, Ladan
   Amouzegar, Atieh
   Rahimabad, Parnian Kheirkhah
   Tohidi, Maryam
   Tahmasebinejad, Zhale
   Azizi, Fereidoun
TI Thyroid Function and Metabolic Syndrome: A Population-Based Thyroid
   Study
SO HORMONE AND METABOLIC RESEARCH
LA English
DT Article
DE metabolic syndrome; thyroid; hypothyroidism; hyperthyroidism
ID DENSITY-LIPOPROTEIN CHOLESTEROL; STIMULATING HORMONE-LEVELS; C-REACTIVE
   PROTEIN; INSULIN-RESISTANCE; OXIDATIVE STRESS; ASSOCIATION; DISEASE;
   TSH; HYPOTHYROIDISM; SENSITIVITY
AB The impact of thyroid dysfunction in subclinical ranges on metabolic syndrome (MetS) is not well known. The aim of the present study is to evaluate the association of thyroid dysfunction with MetS and its components. In the cross-sectional population-based Tehran Thyroid Study, out of 5 786 randomly selected participants, aged >= 20 years, subjects with thyroid nodules and cancer or any severe systemic disease, those who were pregnant and those using thyroid medication were excluded, leaving 5422 subjects to be investigated. Body weight, waist circumference, and blood pressure were measured. Fasting blood glucose and concentrations of lipids and lipoproteins, free T4, and TSH were assayed. Mean age of the participants was 40.3 +/- 14.4 of whom 101 (2 %) had overt hypothyroidism, 294 (5 %) subclinical hypothyroidism, 82 (2 %) overt hyperthyroidism, and 178 (3 %) had subclinical hyperthyroidism; 1 704 (32 %) had MetS. Clinically hypothyroid subjects had the highest prevalence of MetS (41.6 %), abdominal obesity (45 %), and hypertriglyceridemia (58 %) compared to other groups (p < 0.05). Significant odds ratio for prevalent MetS was observed only in clinically hypothyroid men [OR: 2.9, 95 % CI: 1.04, 8.4, p = 0.04]. In women, the association between overt hypothyroidism and MetS was marginally significant only in the crude model [OR: 0.068, 95 % CI (0.97-2.42), p = 0.06]. There was higher risk of Mets in subclinically hypothyroid subjects, aged > 50. Overt and subclinical hyperthyroidism had significantly higher odds of hyperglycemia in men and women after full adjustment for age, smoking, and BMI. Overt hypothyroidism and subclinical hypothyroidism especially in the elderly could be associated with MetS. Hyperthyroidism may induce hyperglycemia.
C1 [Mehran, Ladan; Amouzegar, Atieh; Rahimabad, Parnian Kheirkhah; Tahmasebinejad, Zhale; Azizi, Fereidoun] Shahid Beheshti Univ Med Sci, Endocrine Res Ctr, Res Inst Endocrine Sci, Tehran, Iran.
   [Tohidi, Maryam] Shahid Beheshti Univ Med Sci, Prevent Metab Disorders Res Ctr, Res Inst Endocrine Sci, Tehran, Iran.
C3 Shahid Beheshti University Medical Sciences; Shahid Beheshti University
   Medical Sciences
RP Azizi, F (corresponding author), Shahid Beheshti Univ Med Sci, Res Inst Endocrine Sci, Endocrine Res Ctr, Internal Med & Endocrinol, POB 19395 4763, Tehran, Iran.
EM azizi@endocrine.ac.ir
RI Tohidi, Maryam/V-2261-2019; Amouzegar, Atieh/K-1551-2017; Azizi,
   Fereidoun/ABD-4136-2021
OI amouzegar, atieh/0000-0003-1046-0003; Amouzegar,
   Atieh/0000-0001-9433-9408; Azizi, Fereidoun/0000-0002-6470-2517
FU Research Institute of Endocrine Sciences, Shahid Beheshti University of
   Medical Sciences, Tehran, I. R. Iran
FX The project supported by Research Institute of Endocrine Sciences,
   Shahid Beheshti University of Medical Sciences, Tehran, I. R. Iran. We
   would like to acknowledge the personnel of the laboratory of Research
   Institute for Endocrine Sciences for their collaboration and assistance.
   We also thank Ms. Niloofar Shiva for editing the manuscript.
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NR 47
TC 57
Z9 61
U1 0
U2 27
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0018-5043
EI 1439-4286
J9 HORM METAB RES
JI Horm. Metab. Res.
PD MAR
PY 2017
VL 49
IS 3
BP 192
EP 200
DI 10.1055/s-0042-117279
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA EQ7GA
UT WOS:000398251300006
PM 28351085
DA 2025-06-11
ER

PT J
AU Lee, G
   Yang, SJ
   Chee, YK
AF Lee, Guna
   Yang, Sook Ja
   Chee, Yeon Kyung
TI Assessment of healthy behaviors for metabolic syndrome among Korean
   adults: a modified information-motivation-behavioral skills with
   psychological distress
SO BMC PUBLIC HEALTH
LA English
DT Article
DE Metabolic syndrome; Healthy behavior; Information-motivation-behavioral
   skills model (IMB); Psychological Distress
ID LIFE-STYLE; SOCIAL SUPPORT; SELF-EFFICACY; KNOWLEDGE; RISK; PREDICTION;
   EDUCATION; OUTCOMES; STRESS; WOMEN
AB Background: Since the worldwide incidence of metabolic syndrome (Mets) has rapidly increased, healthy behaviors such as weight control, engaging in physical activity, and healthy diet have been crucial in the management of Mets. The purpose of this study was to examine healthy behaviors practice and factors that affect the practice in relation to Mets on the basis of a modified Information-Motivation-Behavioral skills model (IMB) with psychological distress, which is a well-known factor affecting healthy behaviors among individuals with Mets.
   Methods: Study participants were 267 community dwelling adults (M-age: 54.0 +/- 8.1 years) with Mets who were attending public health centers located in Seoul, South Korea. A structured questionnaire was administered in the areas of information, motivation, behavioral skills, and practice of Mets healthy behaviors and levels of psychological distress from May 2014 to September 2014. Structural equation modeling was used to test the modified IMB model.
   Results: The modified IMB model had a good fit with the data, indicating that motivation and behavioral skills directly influenced the practice of Mets healthy behaviors, whereas information and psychological distress directly influenced motivation and influenced the practice of healthy behaviors through behavioral skills. These components of the modified IMB model explained 29.8 % of the variance in healthy behaviors for Mets.
   Conclusion: Findings suggested that strengthening motivation and behavioral skills for healthy behaviors can directly enhance healthy behavior practice. Providing information about Mets related healthy behaviors and strategies for psychological distress management can be used as the first line evidence based intervention to systemically enhance motivation and behavioral skills among individuals with Mets.
C1 [Lee, Guna; Yang, Sook Ja] Ewha Womans Univ, Coll Nursing, Seoul, South Korea.
   [Chee, Yeon Kyung] Ewha Womans Univ, Dept Child Dev, Seoul, South Korea.
C3 Ewha Womans University; Ewha Womans University
RP Yang, SJ (corresponding author), Ewha Womans Univ, Coll Nursing, Seoul, South Korea.
EM yangsj@ewha.ac.kr
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NR 53
TC 21
Z9 23
U1 1
U2 25
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2458
J9 BMC PUBLIC HEALTH
JI BMC Public Health
PD JUN 18
PY 2016
VL 16
AR 518
DI 10.1186/s12889-016-3185-8
PG 8
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA DO7PO
UT WOS:000377974700001
PM 27317425
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Jeong, SK
   Kim, YK
   Park, JW
   Shin, YJ
   Kim, DS
AF Jeong, Seul-Ki
   Kim, Young-Kon
   Park, Jin-Woo
   Shin, Yong-Ju
   Kim, Dal-Sik
TI Impact of Visceral Fat on the Metabolic Syndrome and Nonalcoholic Fatty
   Liver Disease
SO JOURNAL OF KOREAN MEDICAL SCIENCE
LA English
DT Article
DE Nonalcoholic Fatly Liver Disease; Metabolic Syndrome; Intra-Abdominal
   Fat; Work Index
ID RISK-FACTORS; INSULIN-RESISTANCE; HEPATIC STEATOSIS; PHYSICAL-ACTIVITY;
   OXIDATIVE STRESS; PREVALENCE; DIAGNOSIS; OBESITY
AB Visceral fat has been reported to be associated with nonalcoholic fatty liver disease (NAFLD) and the metabolic syndrome (MetS). We assessed the prevalence of both NAFLD and the MetS, measured visceral fat thickness (VFT), and estimated the physical activity indexes of 224 relatively healthy hospital workers. We also investigated the associations between both VFT and physical activity index and each of NAFLD and the MetS. The MetS was diagnosed according to the guidelines outlined by the Adult Treatment Panel III, and NAFLD was diagnosed by ultrasonography. Subjects with hepatitis B and C infections and those reporting moderate alcohol consumption were excluded from the study. The prevalence of the MetS was 11.6% and that of NAFLD was 41.5%. Many subjects with the MetS had NAFLD (73.1%), and some subjects with NAFLD (20.4%) also had several components of the MetS (p=0.001). VFT was significantly increased by both the addition of components of the MetS and the severity of NAFLD (p < 0.001). In addition, VFT was independently associated with NAFLD (odds ratio [OR], 1.10; 95% confidence interval [CI], 1.02-1.19) in subjects with more than 2 components of the MetS. In contrast, habitual physical activity was reversely associated with NAFLD (OR, 0.29; 95% Cl, 0.10-0.87). In conclusion, an increased visceral fat content and reduced physical activity could be not only biological markers but also therapeutic targets in the treatment of NAFLD and the MetS.
C1 [Kim, Dal-Sik] Chonbuk Natl Univ, Sch Med, Dept Lab Med, Jeonju 561180, South Korea.
   [Jeong, Seul-Ki] Chonbuk Natl Univ, Sch Med, Dept Neurol, Jeonju, South Korea.
   [Kim, Young-Kon] Chonbuk Natl Univ, Sch Med, Dept Diagnost Radiol, Jeonju, South Korea.
   [Park, Jin-Woo] Chonbuk Natl Univ, Sch Med, Dept Biochem, Jeonju, South Korea.
   [Shin, Yong-Ju] Catholic Med Ctr, Dept Internal Med, Seoul, South Korea.
C3 Jeonbuk National University; Jeonbuk National University; Jeonbuk
   National University; Jeonbuk National University
RP Kim, DS (corresponding author), Chonbuk Natl Univ, Sch Med, Dept Lab Med, San 2-20 Geumam Dong, Jeonju 561180, South Korea.
EM dskim@chonbuk.ac.kr
RI Park, Jinwoo/AAD-1328-2022; Jeong, Seul-Ki/KSL-7574-2024
OI Jeong, Seul-Ki/0000-0002-9868-621X
FU Korean Stroke Society Young Investigator's Award [KSS-2006-002]
FX This work was supported in pan by a grant from the Korean Stroke Society
   Young Investigator's Award (KSS-2006-002).We, the authors, would like to
   extend special thanks to Cho MH and Lee JH, and Kim JH for their
   valuable assistance in the study processes and preparation of this
   manuscript. This work was Supported In part by a grant from the Korean
   Stroke Society Young Investigator's Award (KSS2006-002).
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NR 32
TC 26
Z9 34
U1 0
U2 0
PU KOREAN ACAD MEDICAL SCIENCES
PI SEOUL
PA 302 75 DONG DU ICHON, DONG YONGSAN KU, SEOUL 140 031, SOUTH KOREA
SN 1011-8934
EI 1598-6357
J9 J KOREAN MED SCI
JI J. Korean Med. Sci.
PD OCT
PY 2008
VL 23
IS 5
BP 789
EP 795
DI 10.3346/jkms.2008.23.5.789
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 369WP
UT WOS:000260724900007
PM 18955783
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Laurindo, LF
   Rodrigues, VD
   Minniti, G
   de Carvalho, ACA
   Zutin, TLM
   Deliberto, LK
   Bishayee, A
   Barbalho, SM
AF Laurindo, Lucas Fornari
   Rodrigues, Victoria Dogani
   Minniti, Giulia
   de Carvalho, Antonelly Cassio Alves
   Zutin, Tereza Lais Menegucci
   Deliberto, Lindsay K.
   Bishayee, Anupam
   Barbalho, Sandra Maria
TI Pomegranate ( Punica granatum L.) phytochemicals target the components
   of metabolic syndrome
SO JOURNAL OF NUTRITIONAL BIOCHEMISTRY
LA English
DT Review
DE Punica granatum L.; Pomegranate; Metabolic syndrome; Diabetes;
   Hypertension; Dyslipidemia; Obesity
ID ELLAGIC ACID; SEED OIL; FRUIT EXTRACT; GALLIC ACID; ANTIMICROBIAL
   ACTIVITY; INSULIN-RESISTANCE; JUICE CONSUMPTION; OXIDATIVE STRESS; RAT
   MODEL; ANTIOXIDANT
AB Pomegranate (Punica granatum L.) is a multipurpose dietary and medicinal plant known for its ability to promote various health benefits. Metabolic syndrome (MetS) is a complex metabolic disorder driving health and socioeconomic challenges worldwide. It may be characterized by insulin resistance, abdominal obesity, hypertension, and dyslipidemia. This study aims to conduct a review of pomegranate's effects on MetS parameters using a mechanistic approach relying on pre -clinical studies. The peel, juice, roots, bark, seeds, flowers, and leaves of the fruit present several bioactive compounds that are related mainly to anti-inflammatory and antioxidant activities as well as cardioprotective, antidiabetic, and antiobesity effects. The use of the juice extract can work as a potent inhibitor of angiotensin-converting enzyme activities, consequently regulating blood pressure. The major bioactive compounds found within the fruit are phenolic compounds (hydrolysable tannins and flavonoids) and fatty acids. Alkaloids, punicalagin, ellagitannins, ellagic acid, anthocyanins, tannins, flavonoids, luteolin, and punicic acid are also present. The antihyperglycemia, antihyperlipidemia, and weight loss promoting effects are likely related to the anti-inflammatory and antioxidant effects. When considering clinical application, pomegranate extracts are found to be frequently well -tolerated, further supporting its efficacy as a treatment modality. We suggest that pomegranate fruit, extract, or processed products can be used to counteract MetS-related risk factors. This review represents an important step towards exploring potential avenues for further research in this area. (c) 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.
C1 [Laurindo, Lucas Fornari; Rodrigues, Victoria Dogani] Fac Med Marilia FAMEMA, Sch Med, Dept Biochem & Pharmacol, Sao Paulo, SP, Brazil.
   [Laurindo, Lucas Fornari; Minniti, Giulia; de Carvalho, Antonelly Cassio Alves; Zutin, Tereza Lais Menegucci; Barbalho, Sandra Maria] Univ Marilia UNIMAR, Sch Med, Dept Biochem & Pharmacol, BR-17514844 Marilia, Sao Paulo, Brazil.
   [de Carvalho, Antonelly Cassio Alves; Zutin, Tereza Lais Menegucci; Barbalho, Sandra Maria] Univ Marilia UNIMAR, Postgrad Program Struct & Funct Interact Rehabil, Sao Paulo, SP, Brazil.
   [Deliberto, Lindsay K.; Bishayee, Anupam] Lake Erie Coll Osteopath Med, Coll Osteopath Med, Dept Pharmacol, 5000 Lakewood Ranch Blvd, Bradenton, FL 34211 USA.
   [Barbalho, Sandra Maria] Sch Food & Technol Marilia FATEC, Dept Biochem & Nutr, Sao Paulo, SP, Brazil.
C3 Faculdade de Medicina de Marilia; Universidade de Marilia; Universidade
   de Marilia
RP Barbalho, SM (corresponding author), Univ Marilia UNIMAR, Sch Med, Dept Biochem & Pharmacol, BR-17514844 Marilia, Sao Paulo, Brazil.; Bishayee, A (corresponding author), Lake Erie Coll Osteopath Med, Coll Osteopath Med, Dept Pharmacol, 5000 Lakewood Ranch Blvd, Bradenton, FL 34211 USA.
EM abishayee@gmail.com; smbarbalho@gmail.com
RI FORNARI LAURINDO, LUCAS/HZJ-7263-2023; barbalho, sandra/Z-3515-2019;
   Bishayee, Anupam/G-4290-2012
OI FORNARI LAURINDO, LUCAS/0000-0003-3159-0982
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NR 228
TC 12
Z9 12
U1 7
U2 17
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0955-2863
EI 1873-4847
J9 J NUTR BIOCHEM
JI J. Nutr. Biochem.
PD SEP
PY 2024
VL 131
AR 109670
DI 10.1016/j.jnutbio.2024.109670
EA JUN 2024
PG 22
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA UZ8D7
UT WOS:001251969900001
PM 38768871
DA 2025-06-11
ER

PT J
AU Deng, ZZ
   Wu, N
   Wang, J
   Zhang, QB
AF Deng, Zhenzhen
   Wu, Ning
   Wang, Jing
   Zhang, Quanbin
TI Dietary fibers extracted from Saccharina japonica can improve metabolic
   syndrome and ameliorate gut microbiota dysbiosis induced by high fat
   diet
SO JOURNAL OF FUNCTIONAL FOODS
LA English
DT Article
DE Dietary fiber; Insulin resistance; Metabolic syndrome; Gut microbiota
ID INSULIN-RESISTANCE; HEALTH; MODULATION; CURCUMIN; FEATURES; OBESITY;
   LIVER; MODEL; MICE
AB Metabolic syndrome (MetS) is a pathological state of multiple metabolic abnormalities. Dietary fibers (DFs) has been widely concerned about its positive role in MetS. Different from the DFs of terrestrial plants, the DFs of seaweeds has unique composition and structural characteristics. The aim of this study is to investigate the composition and microstructures of DF derived from Saccharina japonica, and its positive effects on MetS mice induced by high fat diet (HFD). We extracted DF from S. japonica (DFSJ). DFSJ has a high proportion of soluble dietary fiber (SDF) and it shows good water holding capacity (11.34 +/- 1.63 g/g) and swelling property (32.9 +/- 2.52 mL/g). Supplementing DFSJ can significantly improve insulin resistance (IR), dyslipidemia in HFD mice. Besides, DFSJ can reduce inflammatory factors (TNF-alpha, MCP-1 and IL-6), improve the hepatic oxidative stress and protect visceral organs from the injury of HFD. Finally, 16S rDNA high-throughput sequencing was used to further analyze the profile changes of gut microbiota. The results indicated that supplementing DFSJ can effectively ameliorate gut microbiota dysbiosis. In particular, DFSJ can increase the relative abundance of some beneficial bacteria, such as Bifidobacterium, Turicibacter and Akkermansia. Our results indicated that DFSJ has a comprehensive regulatory effect on MetS, and it is involved in various regulatory pathways, such as antioxidant, anti-inflammatory, hypoglycemic and hypolipidemic pathways in HFD-induced MetS mice. Our results reveal the great potential of DFSJ as an effective regulator on various metabolic abnormalities of MetS.
C1 [Deng, Zhenzhen; Wu, Ning; Wang, Jing; Zhang, Quanbin] Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, CAS & Shandong Prov Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China.
   [Deng, Zhenzhen; Wang, Jing; Zhang, Quanbin] Qingdao Natl Lab Marine Sci & Tech, Lab Marine Biol & Biotechnol, Qingdao 266071, Peoples R China.
   [Deng, Zhenzhen] Univ Chinese Acad Sci, Beijing 100049, Peoples R China.
C3 Chinese Academy of Sciences; Institute of Oceanology, CAS; Laoshan
   Laboratory; Chinese Academy of Sciences; University of Chinese Academy
   of Sciences, CAS
RP Wang, J; Zhang, QB (corresponding author), Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, CAS & Shandong Prov Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China.; Wang, J; Zhang, QB (corresponding author), Qingdao Natl Lab Marine Sci & Tech, Lab Marine Biol & Biotechnol, Qingdao 266071, Peoples R China.
EM jingwang@qdio.ac.cn; qbzhang@qdio.ac.cn
RI Zhang, Quanbin/IUQ-3663-2023
FU National Key RD Plan of China [2018YFD0901104]; Special Open Fund of
   Laboratory for Marine Biology and Biotechnology, Qingdao Pilot National
   Laboratory for Marine Science and Technology [OF2020NO02]; Major
   Scientific & Engineering Projects of Innovation in Shandong Province
   [2019JZZY010818]; K.C. Wong Education Foundation, CAS
FX The research was supported by the National Key R&D Plan of China (Grant
   No. 2018YFD0901104) ; the Special Open Fund of Laboratory for Marine
   Biology and Biotechnology, Qingdao Pilot National Laboratory for Marine
   Science and Technology (No. OF2020NO02) ; Major Scientific & Engineering
   Projects of Innovation in Shandong Province (Grant No.2019JZZY010818) ,
   and K.C. Wong Education Foundation, CAS.
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NR 41
TC 18
Z9 20
U1 4
U2 49
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1756-4646
EI 2214-9414
J9 J FUNCT FOODS
JI J. Funct. Food.
PD OCT
PY 2021
VL 85
AR 104642
DI 10.1016/j.jff.2021.104642
EA JUL 2021
PG 11
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA UD0HZ
UT WOS:000686899700006
OA gold
DA 2025-06-11
ER

PT J
AU Alegbe, EO
   Terali, K
   Olofinsan, KA
   Surgun, S
   Ogbaga, CC
   Ajiboye, TO
AF Alegbe, Emmanuel Ohifueme
   Terali, Kerem
   Olofinsan, Kolawole Ayodapo
   Surgun, Serdar
   Ogbaga, Chukwuma Collins
   Ajiboye, Taofeek Olakunle
TI Antidiabetic activity-guided isolation of gallic and protocatechuic
   acids from Hibiscus sabdariffa calyxes
SO JOURNAL OF FOOD BIOCHEMISTRY
LA English
DT Article
DE diabetes; gallic acid; glycosidase; Hibiscus sabdariffa; protocatechuic
   acid
ID CUMMINSII STAPF DIELS; OXIDATIVE STRESS; INSULIN-RESISTANCE;
   DETOXIFICATION POTENTIALS; ALPHA-AMYLASE; HYPERGLYCEMIA; ANTIOXIDANT;
   L.; DYSLIPIDEMIA; EXTRACT
AB We isolated and identified gallic and protocatechuic acids as the antidiabetic principles in Hibiscus sabdariffa using solvent extraction, column chromatographic fractionation, and nuclear magnetic resonance (NMR) spectroscopy. Ethylacetate fraction of the aqueous extract of H. sabdariffa inhibited alpha-amylase and alpha-glucosidase with IC50 of 411.73 and 433.93 mu g/ml, respectively. Furthermore, fractions I and II obtained from column chromatography inhibited alpha-amylase with IC50 of 27.03 and 20.12 mu g/ml, and alpha-glucosidase with IC50 of 24.30 and 22.29 mu g/ml, respectively. In addition, the principles reduced the serum glucose and lipid peroxide levels of diabetic rats and with an improvement in the rat lipid profiles and antioxidant defenses. Fractions I and II were identified as protocatechuic acid and gallic acid, respectively, using H-1 and C-13 NMR. Protein-ligand docking showed that these compounds form multiple favorable interactions with the active-site residues of the two glycosidases. Overall, protocatechuic and gallic acids emerge as natural antidiabetic agents. Practical applications Hibiscus sabdariffa (Zoborodo) is a refreshment drink for ceremonial gatherings in Nigeria. Also, its pharmacological use includes diabetes, hypertension, hyperlipidemia, metabolic syndrome, and hepatoprotection. The consumption of this food drink could improve diabetes, hypertension, dyslipidemia, metabolic syndrome, and liver disease. Furthermore, the inhibition of alpha-amylase and alpha-glucosidase could prevent diabetic complications associated with postprandial glucose. Developing the extract of H. sabdariffa calyx as food supplement could be used in managing diabetes and its associated complications such as dyslipidemia, hypertension, and metabolic syndrome.
C1 [Alegbe, Emmanuel Ohifueme; Surgun, Serdar] Nile Univ Nigeria, Fac Nat & Appl Sci, Dept Chem, Abuja, Nigeria.
   [Terali, Kerem] Near East Univ, Dept Med Biochem, Fac Med, Nicosia, Cyprus.
   [Olofinsan, Kolawole Ayodapo] Nile Univ Nigeria, Fac Nat & Appl Sci, Dept Biochem, Abuja, Nigeria.
   [Ogbaga, Chukwuma Collins] Nile Univ Nigeria, Fac Nat & Appl Sci, Dept Biol Sci, Abuja, Nigeria.
   [Ogbaga, Chukwuma Collins] Nile Univ Nigeria, Fac Nat & Appl Sci, Dept Microbiol & Biotechnol, Abuja, Nigeria.
   [Ajiboye, Taofeek Olakunle] Nile Univ Nigeria, Dept Med Biochem, Coll Hlth Sci, Antioxidants Redox Biol & Toxicol Res Grp, Abuja, Nigeria.
C3 Near East University
RP Terali, K (corresponding author), Near East Univ, Dept Med Biochem, Fac Med, Nicosia, Cyprus.
EM kerem.terali@neu.edu.tr
RI Ajiboye, Taofeek/H-5383-2011; olofinsan, Kolawole/AAM-8402-2020; Ogbaga,
   Chukwuma/ABD-5384-2020; Terali, Kerem/Q-3270-2016
OI Surgun, Serdar/0009-0007-5215-9178; Terali, Kerem/0000-0002-9964-6383;
   olofinsan, kolawole/0000-0002-2987-0996
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NR 59
TC 38
Z9 39
U1 1
U2 34
PU WILEY-HINDAWI
PI LONDON
PA ADAM HOUSE, 3RD FL, 1 FITZROY SQ, LONDON, WIT 5HE, ENGLAND
SN 0145-8884
EI 1745-4514
J9 J FOOD BIOCHEM
JI J. Food Biochem.
PD JUL
PY 2019
VL 43
IS 7
AR e12927
DI 10.1111/jfbc.12927
PG 12
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA IH2CS
UT WOS:000474303400044
PM 31353728
OA gold
DA 2025-06-11
ER

PT J
AU Elsamanoudy, AZ
   Abdalla, HA
   Hassanien, M
   Gaballah, MA
AF Elsamanoudy, Ayman Z.
   Abdalla, Hussein Abdelaziz
   Hassanien, Mohammed
   Gaballah, Mohammad A.
TI Spermatozoal cell death-inducing DNA fragmentation factor-α-like
   effector A (CIDEA) gene expression and DNA fragmentation in infertile
   men with metabolic syndrome and normal seminogram
SO DIABETOLOGY & METABOLIC SYNDROME
LA English
DT Article
DE CIDEA; Insulin genes expression; DNA fragmentation; Seminal glucose;
   Male infertility; Metabolic syndrome
ID HUMAN EJACULATED SPERMATOZOA; MALE REPRODUCTIVE FUNCTION; BODY-MASS
   INDEX; DIABETES-MELLITUS; OXIDATIVE STRESS; ADIPOSE-TISSUE;
   MALE-FERTILITY; INSULIN; OBESITY; SEMEN
AB Background: This is the first study to investigate spermatozoal cell death-inducing DNA fragmentation factor-a-like effector A (CIDEA) gene expression and DNA fragmentations in the spermatozoa of men diagnosed with metabolic syndrome (MS) who have normal seminograms with unexplained infertility, and to correlate these parameters with seminal glucose concentration.
   Methods: This study included 120 participants: 75 male subjects with MS (38 fertile and 37 infertile), and a control group of 45 fertile males without MS. HOMA-IR, semen analysis, and biochemical measurement of seminal plasma insulin and glucose levels were carried out. Spermatozoal insulin gene and CIDEA gene expressions were performed by the RT-PCR method. The percentage of spermatozoal DNA fragmentation was also estimated.
   Results: The spermatozoal insulin and CIDEA gene expression, as well as the DNA fragmentation, were significantly higher in the infertile MS group than in the fertile MS group, and significantly higher in both the MS groups than in the control group. Seminal glucose concentration showed significant positive correlations with seminal insulin level, spermatozoa insulin, CIDEA gene expression, and DNA fragmentation. Moreover, there was a positive correlation between spermatozoa CIDEA gene expression and DNA fragmentation.
   Conclusions: It can be concluded that MS may affect male fertility at the molecular level, through its possible inducing effect of spermatozoa CIDEA and insulin gene expression, DNA fragmentation, and increased seminal glucose.
C1 [Elsamanoudy, Ayman Z.; Abdalla, Hussein Abdelaziz] Mansoura Univ, Fac Med, Dept Med Biochem, Mansoura, Egypt.
   [Elsamanoudy, Ayman Z.; Hassanien, Mohammed] King Abdulaziz Univ, Fac Med, Dept Clin Biochem, Jeddah, Saudi Arabia.
   [Gaballah, Mohammad A.] Mansoura Univ, Fac Med, Dept Dermatol Androl & STDs, Mansoura, Egypt.
   [Hassanien, Mohammed] Tanta Univ, Fac Med, Dept Med Biochem, Tanta, Egypt.
C3 Egyptian Knowledge Bank (EKB); Mansoura University; King Abdulaziz
   University; Egyptian Knowledge Bank (EKB); Mansoura University; Egyptian
   Knowledge Bank (EKB); Tanta University
RP Elsamanoudy, AZ (corresponding author), Mansoura Univ, Fac Med, Dept Med Biochem, Mansoura, Egypt.; Elsamanoudy, AZ (corresponding author), King Abdulaziz Univ, Fac Med, Dept Clin Biochem, Jeddah, Saudi Arabia.
EM ayman.elsamanoudy@gmail.com
RI Abdalla, Hussein/AAB-7731-2022; gaballah, mohammad/AAO-8694-2020;
   Hassanien, Mohammed/B-7061-2012; Abdalla, Hussein Abdelaziz/M-6257-2018;
   Elsamanoudy, Ayman/M-6529-2018
OI Hassanien, Mohammed/0000-0001-6559-9710; Abdalla, Hussein
   Abdelaziz/0000-0002-2120-2651; gaballah, mohammad/0000-0001-6271-2511;
   Elsamanoudy, Ayman/0000-0002-8731-6184
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NR 58
TC 9
Z9 9
U1 0
U2 5
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1758-5996
J9 DIABETOL METAB SYNDR
JI Diabetol. Metab. Syndr.
PD NOV 16
PY 2016
VL 8
AR 76
DI 10.1186/s13098-016-0192-y
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA EC2CR
UT WOS:000387917700001
PM 27891185
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Greenberg, S
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   Berliner, S
   Milwidsky, A
AF Greenberg, Sharon
   Shenhar-Tsarfaty, Shani
   Rogowski, Ori
   Shapira, Itzhak
   Zeltser, David
   Weinstein, Talia
   Lahav, Dror
   Vered, Jaffa
   Tovia-Brodie, Oholi
   Arbel, Yaron
   Berliner, Shlomo
   Milwidsky, Assi
TI Exercise-induced albuminuria is related to metabolic syndrome
SO AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
LA English
DT Article
DE exercise-induced albuminuria; metabolic syndrome; stress test
ID LOW-GRADE ALBUMINURIA; INDUCED MICROALBUMINURIA; ENDOTHELIAL
   DYSFUNCTION; ASSOCIATION; RISK; INFLAMMATION; POPULATION; COMPONENTS;
   EVENTS; PEOPLE
AB Microalbuminuria (MA) is a known marker for endothelial dysfunction and future cardiovascular events. Exercise-induced albuminuria (EiA) may precede the appearance of MA. Associations between EiA and metabolic syndrome (MS) have not been assessed so far. Our aim was to investigate this association in a large sample of apparently healthy individuals with no baseline albuminuria. This was a cross-sectional study of 2,027 adults with no overt cardiovascular diseases who took part in a health survey program and had no baseline MA. Diagnosis of MS was based on harmonized criteria. All patients underwent an exercise test (Bruce protocol), and urinary albumin was measured before and after the examination. Urinary albumin-to- creatinine ratio (ACR) values before and after exercise were 0.40 (0.21-0.89) and 1.06 (0.43-2.69) mg/g for median (interquartile range) respectively. A total of 394 (20%) subjects had EiA; ACR rose from normal rest values (0.79 mg/g) to 52.28 mg/g after exercise (P < 0.001); this effect was not shown for the rest of the study population. EiA was related to higher prevalence of MS (13.8% vs. 27.1%, P < 0.001), higher metabolic equivalents (P < 0.001), higher baseline blood pressure (P < 0.001), and higher levels of fasting plasma glucose, triglycerides, and body mass index (P < 0.001). Multivariate binary logistic regression model showed that subjects with MS were 98% more likely to have EiA (95% confidence interval: 1.13-3.46, P = 0.016). In conclusion, EiA in the absence of baseline MA is independently related to MS.
C1 [Greenberg, Sharon; Shenhar-Tsarfaty, Shani; Lahav, Dror; Vered, Jaffa; Berliner, Shlomo; Milwidsky, Assi] Tel Aviv Univ, Sackler Fac Med, Tel Aviv Sourasky Med Ctr, Dept Internal Med E, IL-69978 Tel Aviv, Israel.
   [Rogowski, Ori] Tel Aviv Univ, Sackler Fac Med, Tel Aviv Sourasky Med Ctr, Dept Internal Med C, IL-69978 Tel Aviv, Israel.
   [Zeltser, David] Tel Aviv Univ, Sackler Fac Med, Tel Aviv Sourasky Med Ctr, Dept Internal Med D, IL-69978 Tel Aviv, Israel.
   [Shapira, Itzhak; Tovia-Brodie, Oholi; Arbel, Yaron] Tel Aviv Univ, Sackler Fac Med, Tel Aviv Sourasky Med Ctr, Dept Cardiol, IL-69978 Tel Aviv, Israel.
   [Weinstein, Talia] Tel Aviv Univ, Sackler Fac Med, Tel Aviv Sourasky Med Ctr, Dept Nephrol, IL-69978 Tel Aviv, Israel.
C3 Tel Aviv University; Sackler Faculty of Medicine; Tel Aviv Sourasky
   Medical Center; Tel Aviv University; Sackler Faculty of Medicine; Tel
   Aviv Sourasky Medical Center; Tel Aviv University; Sackler Faculty of
   Medicine; Tel Aviv Sourasky Medical Center; Tel Aviv University; Sackler
   Faculty of Medicine; Tel Aviv Sourasky Medical Center; Tel Aviv
   University; Sackler Faculty of Medicine; Tel Aviv Sourasky Medical
   Center
RP Greenberg, S (corresponding author), Tel Aviv Sourasky Med Ctr, Dept Internal Med E, 6 Weizman St, IL-64239 Tel Aviv, Israel.
EM sharon.greenberg@gmail.com
RI Brodie, Oholi/AAH-6425-2019; Zeltser, David/LYO-6304-2024
OI Shenhar-Tsarfaty, Shani/0000-0002-8268-1799; Greenberg, Sharon
   A./0000-0001-7346-1746
CR Afonso L, 2010, AM J CARDIOL, V106, P976, DOI 10.1016/j.amjcard.2010.05.028
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NR 38
TC 16
Z9 16
U1 0
U2 2
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 1931-857X
EI 1522-1466
J9 AM J PHYSIOL-RENAL
JI Am. J. Physiol.-Renal Physiol.
PD JUN 1
PY 2016
VL 310
IS 11
BP F1192
EP F1196
DI 10.1152/ajprenal.00481.2015
PG 5
WC Physiology; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology; Urology & Nephrology
GA DN9YM
UT WOS:000377436600007
PM 27076648
OA Bronze
DA 2025-06-11
ER

PT J
AU Xie, YL
   Wang, MJ
   Zhang, YJ
   Zhang, SJ
   Tan, AH
   Gao, Y
   Liang, ZJ
   Shi, DY
   Huang, Z
   Zhang, HY
   Yang, XB
   Lu, Z
   Wu, CL
   Liao, M
   Sun, Y
   Qin, X
   Hu, YL
   Li, L
   Peng, T
   Li, ZX
   Yang, XL
   Mo, ZN
AF Xie, Yuanliang
   Wang, Mengjie
   Zhang, Youjie
   Zhang, Shijun
   Tan, Aihua
   Gao, Yong
   Liang, Zhengjia
   Shi, Deyi
   Huang, Zhang
   Zhang, Haiying
   Yang, Xiaobo
   Lu, Zheng
   Wu, Chunlei
   Liao, Ming
   Sun, Yu
   Qin, Xue
   Hu, Yanling
   Li, Li
   Peng, Tao
   Li, Zhixian
   Yang, Xiaoli
   Mo, Zengnan
TI Serum Uric Acid and Non-Alcoholic Fatty Liver Disease in Non-Diabetic
   Chinese Men
SO PLOS ONE
LA English
DT Article
ID METABOLIC SYNDROME; INSULIN-RESISTANCE; NATIONAL-HEALTH; RISK-FACTORS;
   ASSOCIATION; PREVALENCE; NUTRITION; GENE; HYPERURICEMIA; POPULATION
AB Increased serum uric acid (SUA) levels may be involved in the development of non-alcoholic fatty liver disease (NAFLD) in men presenting with metabolic syndrome (MetS) and/or insulin resistance. We aimed to determine the independent relationship between SUA and NAFLD in non-diabetic Chinese male population, and to explore the determinants of SUA levels among indexes of adiposity, lipid, and genotypes pertaining to triglycerides metabolism, inflammation, oxidative stress, and SUA concentrations. A total of 1440 men, classified depending on the presence of ultrasonographically detected NAFLD, underwent a complete healthy checkup program. Genotypes were extracted from our previously established genome-wide association study database. After adjusting for age, smoking, drinking, body mass index, homeostasis model assessment of insulin resistance, C-reactive protein, creatinine, alanine aminotransferase (ALT) and components of metabolic syndrome, the odds ratio for NAFLD, comparing the highest with the lowest SUA quartile, was 2.81 (95% confidence interval 1.66-4.76). A stepwise multivariate linear regression analysis (R-2 = 0.238, P<0.001) retained age, waist circumference, serum creatinine, triglycerides, the Q141K variant in ABCG2 (rs2231142) and NAFLD as significant predictors of SUA levels (all P<0.001). Besides, ALT and Met196Arg variant in TNFRSF1B (rs1061622) additionally associated with SUA among individuls with NAFLD. Our data suggest that in Chinese men, elevated SUA is significantly associated with NAFLD, independent of insulin resistance and other metabolic disorders, such as central obesity or hypertriglyceridemia. Meanwhile, among subjects with NAFLD, index of liver damage, such as elevated ALT combined with genetic susceptibility to inflammation associated with increased SUA levels.
C1 [Xie, Yuanliang; Zhang, Youjie; Lu, Zheng; Wu, Chunlei; Liao, Ming; Mo, Zengnan] Guangxi Med Univ, Affiliated Hosp 1, Inst Urol & Nephrol, Nanning, Guangxi Zhuang, Peoples R China.
   [Wang, Mengjie; Zhang, Shijun; Tan, Aihua; Gao, Yong; Mo, Zengnan] Guangxi Med Univ, Ctr Genom & Personalized Med, Nanning, Guangxi Zhuang, Peoples R China.
   [Liang, Zhengjia; Shi, Deyi; Huang, Zhang] Fangchenggang First Peoples Hosp, Med Examinat Ctr, Fangchenggang, Guangxi Zhuang, Peoples R China.
   [Zhang, Haiying; Yang, Xiaobo] Guangxi Med Univ, Sch Publ Hlth, Dept Occupat Hlth & Environm Hlth, Nanning, Guangxi Zhuang, Peoples R China.
   [Sun, Yu; Li, Zhixian] Guangxi Med Univ, Affiliated Hosp 1, Dept Ultrasound, Nanning, Guangxi Zhuang, Peoples R China.
   [Qin, Xue] Guangxi Med Univ, Affiliated Hosp 1, Dept Clin Lab, Nanning, Guangxi Zhuang, Peoples R China.
   [Hu, Yanling; Li, Li; Yang, Xiaoli] Guangxi Med Univ, Med Sci Res Ctr, Nanning, Guangxi Zhuang, Peoples R China.
   [Peng, Tao] Guangxi Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Nanning, Guangxi Zhuang, Peoples R China.
C3 Guangxi Medical University; Guangxi Medical University; Guangxi Medical
   University; Guangxi Medical University; Guangxi Medical University;
   Guangxi Medical University; Guangxi Medical University
RP Yang, XL (corresponding author), Guangxi Med Univ, Med Sci Res Ctr, Nanning, Guangxi Zhuang, Peoples R China.
EM cncsyxl@gmail.com
RI Wu, Chunlei/ABF-4720-2020; Yang, Xiaobo/G-3854-2016; Peng,
   Tao/LXB-5171-2024; Wang, xiaoxiao/GQQ-2846-2022; qin, xue/KQV-3701-2024;
   Hu, Yanling/LTZ-0129-2024; Liao, Ming/LEL-9197-2024; Xie,
   Yuanliang/KIC-3241-2024; Zhang, Youjie/F-7346-2016
OI mo, zengnan/0000-0002-3047-3138; Zhang, Youjie/0000-0002-6035-8536
FU National Natural Science Foundation of China [81060029, 81060234,
   30945204, 81060214]; Key Program and University Talents Highland
   Innovation Team of Guangxi [2012012D003, GJR201147-09]; Chairman Science
   and Technology Fund and Tackle Program of Guangxi [1116-03,
   GKG1298003-07-01]; Guangxi Provincial Department of Finance and
   Education [2009GJCJ150]; Guangxi Natural Science Foundation
   [2011GXNSFA018175, 2010GXNSFA013133]
FX The work described in this article was supported by grants from the
   National Natural Science Foundation of China (81060029, 81060234,
   30945204, 81060214), Key Program and University Talents Highland
   Innovation Team of Guangxi (2012012D003, GJR201147-09), Chairman Science
   and Technology Fund and Tackle Program of Guangxi (1116-03,
   GKG1298003-07-01), Guangxi Provincial Department of Finance and
   Education (2009GJCJ150), and Guangxi Natural Science Foundation
   (2011GXNSFA018175, and 2010GXNSFA013133). The funders had no role in
   study design, data collection and analysis, decision to publish, or
   preparation of the manuscript.
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NR 41
TC 37
Z9 44
U1 0
U2 20
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JUL 23
PY 2013
VL 8
IS 7
AR e67152
DI 10.1371/journal.pone.0067152
PG 7
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 228SX
UT WOS:000325211000009
PM 23935829
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Campia, U
   Tesauro, M
   Cardillo, C
AF Campia, Umberto
   Tesauro, Manfredi
   Cardillo, Carmine
TI Human obesity and endothelium-dependent responsiveness
SO BRITISH JOURNAL OF PHARMACOLOGY
LA English
DT Review
DE Obesity; endothelium; metabolic syndrome; vasodilation; oxidative stress
ID NECROSIS-FACTOR-ALPHA; PERIVASCULAR ADIPOSE-TISSUE; ACTIVATED
   PROTEIN-KINASE; NITRIC-OXIDE SYNTHASE; BODY-FAT DISTRIBUTION;
   CARDIOVASCULAR RISK-FACTORS; TYPE-2 DIABETES-MELLITUS; PERIPHERAL-BLOOD
   FLOW; INSULIN-RESISTANCE; METABOLIC SYNDROME
AB Obesity is an ongoing worldwide epidemic. Besides being a medical condition in itself, obesity dramatically increases the risk of development of metabolic and cardiovascular disease. This risk appears to stem from multiple abnormalities in adipose tissue function leading to a chronic inflammatory state and to dysregulation of the endocrine and paracrine actions of adipocyte-derived factors. These, in turn, disrupt vascular homeostasis by causing an imbalance between the NO pathway and the endothelin 1 system, with impaired insulin-stimulated endothelium-dependent vasodilation. Importantly, emerging evidence suggests that the vascular dysfunction of obesity is not just limited to the endothelium, but also involves the other layers of the vessel wall. In particular, obesity-related changes in medial smooth muscle cells seem to disrupt the physiological facilitatory action of insulin on the responsiveness to vasodilator stimuli, whereas the adventitia and perivascular fat appear to be a source of pro-inflammatory and vasoactive factors that may contribute to endothelial and smooth muscle cell dysfunction, and to the pathogenesis of vascular disease. While obesity-induced vascular dysfunction appears to be reversible, at least in part, with weight control strategies, these have not proved sufficient to prevent the metabolic and cardiovascular complication of obesity on a large scale. While a number of currently available drugs have shown potentially beneficial vascular effects in patients with obesity and the metabolic syndrome, elucidation of the pathophysiological mechanisms underlying vascular damage in obese patients is necessary to identify additional pharmacologic targets to prevent the cardiovascular complications of obesity, and their human and economic costs.
C1 [Cardillo, Carmine] Univ Cattolica Sacro Cuore, Ist Patol Speciale Med & Semeiot, Dept Internal Med, I-00168 Rome, Italy.
   [Campia, Umberto] Northwestern Univ, Dept Cardiol, Feinberg Sch Med, Chicago, IL 60611 USA.
   [Tesauro, Manfredi] Univ Roma Tor Vergata, Dept Internal Med, Rome, Italy.
C3 Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli;
   Northwestern University; Feinberg School of Medicine; University of Rome
   Tor Vergata
RP Cardillo, C (corresponding author), Univ Cattolica Sacro Cuore, Ist Patol Speciale Med & Semeiot, Dept Internal Med, Largo Gemelli 8, I-00168 Rome, Italy.
EM carmine.cardillo@rm.unicatt.it
OI Cardillo, Carmine/0000-0001-5182-3005
FU National Institutes of Health [K12-HL083790]; Fondazione Roma;
   Universita Cattolica del Sacro Cuore
FX This work was partially supported by a National Institutes of Health
   grant (K12-HL083790) to UC, by Fondazione Roma grant to MT, and by Fondi
   d'Ateneo grants from the Universita Cattolica del Sacro Cuore to CC.
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NR 132
TC 91
Z9 105
U1 0
U2 9
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0007-1188
EI 1476-5381
J9 BRIT J PHARMACOL
JI Br. J. Pharmacol.
PD FEB
PY 2012
VL 165
IS 3
SI SI
BP 561
EP 573
DI 10.1111/j.1476-5381.2011.01661.x
PG 13
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 874JS
UT WOS:000298953100003
PM 21895631
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Kamaura, M
   Nishijima, K
   Takahashi, M
   Ando, T
   Mizushima, S
   Tochikubo, O
AF Kamaura, Mitsumasa
   Nishijima, Kiyoko
   Takahashi, Mitsuo
   Ando, Toshihiko
   Mizushima, Shunsaku
   Tochikubo, Osamu
TI Lifestyle Modification in Metabolic Syndrome and Associated Changes in
   Plasma Amino Acid Profiles
SO CIRCULATION JOURNAL
LA English
DT Article
DE Amino acid; Lifestyle modification; Metabolic syndrome
ID OXIDATIVE STRESS; EXERCISE INTERVENTION; NITRIC-OXIDE; INFLAMMATION;
   DISEASE; OBESITY; RISK; DIAGNOSIS; PATHWAY; GLUCOSE
AB Background: Although lifestyle modification is the key treatment of metabolic syndrome (MetS), clinical data on the dynamical relationship between metabolic state and MetS has been limited. This study investigated the mutual correlations between demographic and biochemical variables, and the metabolic state based on the plasma amino acid (AA) concentrations, during a lifestyle modification for MetS.
   Methods and Results: Japanese subjects, consisting of 54 patients with MetS [MetS(+)] and 35 persons without MetS [MetS(-)] were included in the study. Before a lifestyle modification program, the levels of glutamate metabolism-related AA (Glu-mAA), aromatic AA metabolism-related AA (Aromatic-mAA) and alanine metabolism-related AA (Ala-mAA) were significantly higher, while those of glycine-serine-threonine metabolism-related AA (Gly-Ser-Thr-mAA) were significantly lower compared to those in MetS(-). After a lifestyle modification, significant reductions (P<0.05) in the BMI (-1.4 kg/m(2)), mean blood pressure (-7.9 mmHg), hemoglobin A(1c) (-0.4%), and triglycerides (-30.6 mg/dl) were observed, and significant differences in the plasma AA levels between MetS(+) and MetS(-) were resolved. In addition, the diagnostic items of MetS were positively correlated with the levels of Glu-mAA, Ala-mAA, branched chain AA (BCAA)-mAA, Aromatic-mAA, and negatively correlated with the levels of Gly-Ser-Thr-mAA.
   Conclusions: As MetS subsided, the abnormality of mean plasma AA levels of the MetS(+) group returned to similar values as those in the MetS() group, suggesting a novel viewpoint regarding the metabolic mechanism of lifestyle modification. (Circ J 2010; 74: 2434-2440)
C1 [Kamaura, Mitsumasa] Kanagawa Hlth Serv Assoc, Dept Occupat Hlth, Kanazawa Ku, Yokohama, Kanagawa 2368530, Japan.
   [Takahashi, Mitsuo; Ando, Toshihiko] Ajinomoto Co Inc, Inst Life Sci, Kawasaki, Kanagawa, Japan.
   [Nishijima, Kiyoko; Mizushima, Shunsaku; Tochikubo, Osamu] Yokohama City Univ, Sch Med, Dept Publ Hlth, Yokohama, Kanagawa 232, Japan.
C3 Ajinomoto Co Inc; Yokohama City University
RP Kamaura, M (corresponding author), Kanagawa Hlth Serv Assoc, Dept Occupat Hlth, Kanazawa Ku, 13-7 Torihama Machi, Yokohama, Kanagawa 2368530, Japan.
EM m-kamaura@yobouigaku-kanagawa.or.jp
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NR 36
TC 29
Z9 32
U1 0
U2 4
PU JAPANESE CIRCULATION SOC
PI TOYKO
PA 18TH FLOOR IMPERIAL HOTEL TOWER, 1-1-1 UCHISAIWAI-CHO CHIYODA-KU, TOYKO,
   100-0011, JAPAN
SN 1346-9843
EI 1347-4820
J9 CIRC J
JI Circ. J.
PD NOV
PY 2010
VL 74
IS 11
BP 2434
EP 2440
DI 10.1253/circj.CJ-10-0150
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 672YG
UT WOS:000283623200032
PM 20834187
OA Bronze
DA 2025-06-11
ER

PT J
AU Giralt, M
   Díaz-Delfín, J
   Gallego-Escuredo, JM
   Villarroya, J
   Domingo, P
   Villarroya, F
AF Giralt, Marta
   Diaz-Delfin, Julieta
   Gallego-Escuredo, Jose M.
   Villarroya, Joan
   Domingo, Pere
   Villarroya, Francesc
TI Lipotoxicity on the Basis of Metabolic Syndrome and Lipodystrophy in
   HIV-1-Infected Patients Under Antiretroviral Treatment
SO CURRENT PHARMACEUTICAL DESIGN
LA English
DT Review
DE Lipotoxicity; lipodystrophy; HIV; fatty acids; adipose tissue
ID CONGENITAL GENERALIZED LIPODYSTROPHY; FAMILIAL PARTIAL LIPODYSTROPHY;
   ENDOPLASMIC-RETICULUM STRESS; HIV-ASSOCIATED LIPODYSTROPHY;
   ADIPOSE-TISSUE; INSULIN-RESISTANCE; PPAR-GAMMA; GROWTH-HORMONE; PROTEASE
   INHIBITOR; MOUSE MODELS
AB The development of efficacious antiretroviral drugs that minimize adverse effects is a current challenge in HIV-1 therapy. Metabolic alterations reminiscent of the metabolic syndrome and overt lipodystrophy appear often in HIV-1-infected patients undergoing antiretroviral treatment. The etiopathogenesis of these alterations is complex, but lipotoxicity has recently emerged as a key concept for explaining the metabolic syndrome in HIV-1-infected patients, similarly to what has been observed in diseases such as obesity and genetic lipodystrophies. Antiretroviral drugs from distinct drug families may directly elicit such lipotoxic phenomena, via increased lipolysis, enhanced adipocyte apoptosis and impaired adipogenesis, which collectively lead to a reduced capacity of subcutaneous adipose tissue to enlarge to meet fat storage requirements. Thus, fatty acids that cannot be properly stored as triglycerides in subcutaneous adipose tissue are expected to accumulate in visceral fat as well as in organs and tissues, such as the pancreas, muscle and liver, leading to the pattern of metabolic alterations associated with abnormal ectopic fat accumulation, mainly insulin resistance. Inflammatory responses, evoked by the combined effects of antiretroviral drugs and the underlying HIV-1 infection, also contribute to lipotoxicity, reflecting the action of pro-inflammatory cytokines that enhance lipolytic activity in adipose tissue and impair adipogenesis. Minimizing the lipotoxic action of antiretroviral drugs is ultimately essential in reducing metabolic alterations in treated patients. Moreover, pharmacological strategies that reduce lipotoxicity and promote adipose tissue expandability can be expected to ameliorate the overall metabolic abnormalities in HIV-1-infected, antiretroviral-treated patients.
C1 [Giralt, Marta] Univ Barcelona, Fac Biol, Dept Biochem & Mol Biol, E-08028 Barcelona, Spain.
   [Giralt, Marta; Diaz-Delfin, Julieta; Gallego-Escuredo, Jose M.; Villarroya, Joan; Villarroya, Francesc] Univ Barcelona, Inst Biomed IBUB, E-08028 Barcelona, Spain.
   [Giralt, Marta; Diaz-Delfin, Julieta; Gallego-Escuredo, Jose M.; Villarroya, Joan; Villarroya, Francesc] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nut, Barcelona, Spain.
   [Domingo, Pere] Hosp Santa Creu & Sant Pau, Dept Internal Med, Barcelona, Spain.
   [Villarroya, Joan; Domingo, Pere] Hosp Santa Creu & Sant Pau, Inst Recerca, Barcelona, Spain.
C3 University of Barcelona; University of Barcelona; Instituto de Salud
   Carlos III; Hospital of Santa Creu i Sant Pau; Autonomous University of
   Barcelona; Hospital Universitari Vall d'Hebron; Vall d'Hebron Institut
   de Recerca (VHIR); Hospital of Santa Creu i Sant Pau
RP Giralt, M (corresponding author), Univ Barcelona, Fac Biol, Dept Biochem & Mol Biol, Avda Diagonal 645, E-08028 Barcelona, Spain.
EM mgiralt@ub.edu
RI Domingo, Pere/AAP-7571-2021; Villarroya, Francesc/K-4357-2014;
   Villarroya, Joan/W-4066-2018; Giralt, Marta/A-4756-2013
OI Villarroya, Joan/0000-0002-7859-1109; Villarroya,
   Francesc/0000-0003-1266-9142; GALLEGO-ESCUREDO, JOSE
   MIGUEL/0000-0001-7899-8585; Giralt, Marta/0000-0001-7968-4190
FU Ministerio de Ciencia e Innovacion [SAF2008- 01896]; Instituto de Salud
   Carlos III [PI08/1715]; Red de Investigacion en SIDA [RIS RD06/006]
FX Supported by grants from Ministerio de Ciencia e Innovacion (SAF2008-
   01896), Instituto de Salud Carlos III (PI08/1715) and Red de
   Investigacion en SIDA (RIS RD06/006). Thanks are given to V. Carreno for
   support in the design of the Fig. (1).
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NR 82
TC 20
Z9 23
U1 0
U2 1
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1381-6128
EI 1873-4286
J9 CURR PHARM DESIGN
JI Curr. Pharm. Design
PY 2010
VL 16
IS 30
BP 3372
EP 3378
DI 10.2174/138161210793563527
PG 7
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 688BP
UT WOS:000284824500005
PM 20687888
DA 2025-06-11
ER

PT J
AU Tükel, HC
   Delilbasi, E
AF Tukel, Huseyin Can
   Delilbasi, Ertan
TI Effects of metabolic syndrome on jawbones and bone metabolic markers in
   sucrose-fed rats
SO ODONTOLOGY
LA English
DT Article
DE Mandible; Metabolic syndrome; Bone mineral density; Bone-specific
   tartrate-resistant acid phosphatase-5b; Sucrose
ID MINERAL DENSITY; OXIDATIVE STRESS; ALKALINE-PHOSPHATASE;
   INSULIN-RESISTANCE; ALVEOLAR BONE; HIGH-FAT; DIET; INFLAMMATION;
   FRUCTOSE; DISEASE
AB The aim of this study was to investigate the effects of metabolic syndrome (MetS) on bone mineral density (BMD) and microstructure of jawbones, and circulating bone metabolic markers. MetS was induced in male Wistar rats by a 16-week high-sucrose drinking water diet. Mandibles were analyzed for BMD and microstructure by standard radiographs and X-ray diffraction. BMD of three different regions of mandible in MetS group was significantly lower compared to control group. The diffraction intensity of mandibular bone in MetS group was significantly decreased (8.2%) compared to control group; however, crystallite radiuses of mandibular bone samples in both groups were not significantly different. In MetS group, serum bone-specific tartrate-resistant acid phosphatase-5b (TRACP-5b) activity was significantly increased (47%), whereas bone-specific alkaline phosphatase (BALP) activity was significantly decreased (44%) compared to control group. The serum magnesium level in MetS rats (1.82 +/- 0.27 mg dL(-1)) was lower than that of controls (2.11 +/- 0.16 mg dL(-1)). Rats with MetS had significantly higher serum calcium level (9.70 +/- 0.41 mg dL(-1)) than the controls (9.21 +/- 0.50 mg dL(-1)). Overall data suggested that MetS is associated with a significant decrease in BMD and slight deterioration in microcrystallite structure of the jawbones. The changes in TRACP-5b and BALP activities and serum Ca2+ and Mg2+ concentrations also support these findings at a biochemical level.
C1 [Tukel, Huseyin Can] Cukurova Univ, Fac Dent, Dept Oral & Maxillofacial Surg, TR-01330 Adana, Turkey.
   [Delilbasi, Ertan] Gazi Univ, Fac Dent, Dept Oral & Maxillofacial Surg, Ankara, Turkey.
C3 Cukurova University; Gazi University
RP Tükel, HC (corresponding author), Cukurova Univ, Fac Dent, Dept Oral & Maxillofacial Surg, TR-01330 Adana, Turkey.
EM cantukel@gmail.com
RI tükel, hüseyin/J-9250-2018
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NR 46
TC 6
Z9 8
U1 0
U2 2
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1618-1247
EI 1618-1255
J9 ODONTOLOGY
JI Odontology
PD OCT
PY 2019
VL 107
IS 4
BP 457
EP 464
DI 10.1007/s10266-019-00422-w
PG 8
WC Dentistry, Oral Surgery & Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dentistry, Oral Surgery & Medicine
GA IV9WS
UT WOS:000484615000004
PM 30911855
DA 2025-06-11
ER

PT J
AU Ichikawa, J
   Okada, A
   Taguchi, K
   Fujii, Y
   Zuo, L
   Niimi, K
   Hamamoto, S
   Kubota, Y
   Umemoto, Y
   Itoh, Y
   Yasui, T
   Kawai, N
   Tozawa, K
   Kohri, K
AF Ichikawa, Jun
   Okada, Atsushi
   Taguchi, Kazumi
   Fujii, Yasuhiro
   Zuo, Li
   Niimi, Kazuhiro
   Hamamoto, Shuzo
   Kubota, Yasue
   Umemoto, Yukihiro
   Itoh, Yasunori
   Yasui, Takahiro
   Kawai, Noriyasu
   Tozawa, Keiichi
   Kohri, Kenjiro
TI Increased crystal-cell interaction in vitro under co-culture of renal
   tubular cells and adipocytes by in vitro co-culture paracrine systems
   simulating metabolic syndrome
SO UROLITHIASIS
LA English
DT Article
DE Osteopontin; TNF-alpha; Kidney stone; Metabolic syndrome; Paracrine
ID CALCIUM-OXALATE CRYSTALS; ADIPOSE-TISSUE; OXIDATIVE STRESS;
   INSULIN-RESISTANCE; EPITHELIAL-CELLS; OSTEOPONTIN; EXPRESSION; OBESITY;
   ADIPONECTIN; ADHESION
AB We established an experimental co-culture system for renal tubular cells and adipocytes to investigate kidney stone formation mechanisms under metabolic syndrome (MetS) conditions and examined the interaction between these cells morphologically and genetically. M-1s and 3T3-L1s were cultured individually (control, CON), with 24-h culture media from each cell type added to the other cell type (replacement, RP) in 2-layer co-culture dishes for 24 h (transwell, TW). M-1s were then exposed to calcium oxalate monohydrate (COM) crystals, and attached C-14-labeled COM crystals were quantified. Expression of kidney stone- and adipocyte-related genes was analyzed. The radioactivity of adherent COM crystals significantly increased in TW and was relatively higher in RP compared to CON. M-1s demonstrated significant upregulation of adiponectin (Adipoq) in RP and secreted phosphoprotein 1 (Spp1) in TW compared to CON before COM crystal exposure, and significant downregulation of Spp1 in TW and upregulation of tumor necrosis factor (Tnf), interleukin 6 (Il-6), and chemokine (C-C motif) ligand 2 (Ccl2) compared to CON after COM crystal exposure. 3T3-L1s showed significant upregulation of Spp1, Adipoq, Tnf-alpha, and Ccl2 compared to CON. Enzyme-linked immunosorbent assays of co-culture medium revealed significantly increased TNF-alpha in TW. Our results highlight the potential for paracrine interactions between renal tubular cells and adipocytes and suggest that MetS conditions may lead to kidney stone formation.
C1 [Ichikawa, Jun; Okada, Atsushi; Taguchi, Kazumi; Fujii, Yasuhiro; Zuo, Li; Niimi, Kazuhiro; Hamamoto, Shuzo; Kubota, Yasue; Umemoto, Yukihiro; Itoh, Yasunori; Yasui, Takahiro; Kawai, Noriyasu; Tozawa, Keiichi; Kohri, Kenjiro] Nagoya City Univ, Grad Sch Med Sci, Dept Nephrourol, Mizuho Ku, Nagoya, Aichi 4678601, Japan.
C3 Nagoya City University
RP Okada, A (corresponding author), Nagoya City Univ, Grad Sch Med Sci, Dept Nephrourol, Mizuho Ku, 1 Kawasumi, Nagoya, Aichi 4678601, Japan.
EM a-okada@med.nagoya-cu.ac.jp
RI Taguchi, Kazumi/AFU-4486-2022; YASUI, Takahiro/E-6401-2018
OI Okada, Atsushi/0000-0003-2080-3794; Taguchi, Kazumi/0000-0002-3092-5114;
   Yasui, Takahiro/0000-0003-2197-2477
FU Japanese Ministry of Education, Culture, Sports, Science and Technology
   [23249074, 23592374, 23592375, 23791770, 23791774, 23791775, 22591797,
   22791481, 22791479, 22791484, 21791517, 21791520]; Grants-in-Aid for
   Scientific Research [25861443, 24689060, 25462521, 22791484, 23791770,
   25670685, 21791517, 23592375, 22791479, 24659716, 23791775, 23249074,
   23791774, 22791481, 23592374, 24791663, 21791520, 22591797] Funding
   Source: KAKEN
FX We thank Ms. N. Kasuga, Ms. Kawamura, and Ms. Ichikawa for their
   secretarial assistance. This work was partly supported by Grants-in-Aid
   for Scientific Research (Nos. 23249074, 23592374, 23592375, 23791770,
   23791774, 23791775, 22591797, 22791481, 22791479, 22791484, 21791517,
   and 21791520) from the Japanese Ministry of Education, Culture, Sports,
   Science and Technology.
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NR 45
TC 12
Z9 13
U1 0
U2 16
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 2194-7228
EI 2194-7236
J9 UROLITHIASIS
JI Urolithiasis
PD FEB
PY 2014
VL 42
IS 1
BP 17
EP 28
DI 10.1007/s00240-013-0612-5
PG 12
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 302SJ
UT WOS:000330624900003
PM 24162953
DA 2025-06-11
ER

PT J
AU Mure, K
   Maeda, S
   Mukoubayashi, C
   Mugitani, K
   Iwane, M
   Kinoshita, F
   Mohara, O
   Takeshita, T
AF Mure, Kanae
   Maeda, Shinya
   Mukoubayashi, Chizu
   Mugitani, Kouichi
   Iwane, Masataka
   Kinoshita, Fujihisa
   Mohara, Osamu
   Takeshita, Tatsuya
TI Habitual coffee consumption inversely associated with metabolic
   syndrome-related biomarkers involving adiponectin
SO NUTRITION
LA English
DT Article
DE Coffee; Metabolic syndrome; Visceral fat area; Adiponectin; Subcutaneous
   fat area
ID GLUCOSE-METABOLISM; INSULIN-RESISTANCE; OXIDATIVE STRESS; TEA
   CONSUMPTION; GREEN TEA; RISK; INFLAMMATION; METAANALYSIS; DISEASE;
   HEALTH
AB Objectives: The goal of this cross-sectional study was to assess whether habitual coffee consumption shows beneficial association with metabolic syndrome (MetS) in adults.
   Methods: The association of coffee consumption and MetS-related biomarkers including visceral fat area (VFA) and subcutaneous fat area (SFA), total serum adiponectin (T-Ad), low-molecular-weight serum adiponectin (LMW-AD), medium-molecular-weight serum adiponectin (MMW-Ad), and high-molecular-weight serum adiponectin (HMW-Ad) levels were analyzed among 364 Japanese men (36-61 y old) using two models of multivariate regression analyses; model 1 (adjusted for age, alcohol drinking, smoking, and walking status) and model 2 (adjusted for body mass index in addition to model I analysis). Participants were categorized into two groups according to their MetS risk score (raised blood pressure and hemoglobin A(1c) levels, and reduced high-density lipoprotein cholesterol levels).
   Results: Both light (1-3 cups/d) and moderate (>= 4 cups/d) coffee consumption showed significant inverse associations with VFA and VFA/SFA ratio (P < 0.0001). Moderate coffee consumption showed a favorable tendency toward these associations with T-Ad (P = 0.06) and HMW-Ad (P = 0.07) levels in model 1 analysis. In participants with lower MetS risk score (<= 1), moderate coffee consumption showed significant associations with 1-Ad and HMW-Ad levels (P < 0.05) in both analyses, whereas no significant associations of coffee consumption with adiponectin levels were seen in the men with higher MetS risk scores (>= 2).
   Conclusions: Habitual moderate coffee consumption shows significant inverse associations with MetS-related biomarkers possibly involving adiponectin, which is inversely related to visceral fat accumulation. (C) 2013 Elsevier Inc. All rights reserved.
C1 [Mure, Kanae; Maeda, Shinya; Takeshita, Tatsuya] Wakayama Med Univ, Sch Med, Dept Publ Hlth, Wakayama, Japan.
   [Maeda, Shinya; Mukoubayashi, Chizu; Mugitani, Kouichi; Iwane, Masataka; Kinoshita, Fujihisa; Mohara, Osamu] Wakayama Wellness Fdn, Wakayama, Japan.
C3 Wakayama Medical University
RP Takeshita, T (corresponding author), Wakayama Med Univ, Sch Med, Dept Publ Hlth, Wakayama, Japan.
EM ttakeshi@wakayama-med.ac.jp
OI Takeshita, Tatsuya/0000-0002-8609-6896
FU Ministry of Education, Culture, Sports, Science and Technology, Japan
   [17590524, 21590658]; Grants-in-Aid for Scientific Research [25460811,
   17590524, 21590658] Funding Source: KAKEN
FX A Grant-in-Aid for Scientific Research was received from the Ministry of
   Education, Culture, Sports, Science and Technology, Japan (17590524 and
   21590658).
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NR 48
TC 27
Z9 28
U1 0
U2 13
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0899-9007
EI 1873-1244
J9 NUTRITION
JI Nutrition
PD JUL-AUG
PY 2013
VL 29
IS 7-8
BP 982
EP 987
DI 10.1016/j.nut.2013.01.011
PG 6
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 172UF
UT WOS:000321029700010
PM 23602227
DA 2025-06-11
ER

PT J
AU Chiu, CC
   Chen, CH
   Huang, MC
   Chen, PY
   Tsai, CJ
   Lu, ML
AF Chiu, Chih-Chiang
   Chen, Chun-Hsin
   Huang, Ming-Chyi
   Chen, Po-Yu
   Tsai, Chang-Jer
   Lu, Mong-Liang
TI The Relationship Between Serum Uric Acid Concentration and Metabolic
   Syndrome in Patients With Schizophrenia or Schizoaffective Disorder
SO JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
LA English
DT Article
DE metabolic syndrome; uric acid; hyperuricemia; schizophrenia;
   antipsychotics
ID OXIDATIVE STRESS; CARDIOVASCULAR-DISEASE; CAROTID ATHEROSCLEROSIS;
   INSULIN-RESISTANCE; RISK-FACTORS; HYPERURICEMIA; PREVALENCE;
   ASSOCIATION; POPULATION; GLUCOSE
AB Higher prevalence rates of metabolic syndrome (MetS) in patients with schizophrenia are getting more and more attention. Uric acid (UA) has been frequently reported to be associated with MetS in the general population. Sex difference in this relationship is inconsistent. As a selective antioxidant, UA has also been found to be reduced in patients with schizophrenia, and this effect may be prominent in men. With the inconsistent presentations, higher rate of MetS but possible lower UA concentrations, the aim of this study was to investigate the relationship by sexes between serum UA concentrations and prevalence of MetS in patients with schizophrenia or schizoaffective disorder. A total of 637 patients, 342 male and 295 female, were enrolled from 36 psychiatric rehabilitation institutions. Cross-sectional anthropometrical data, biochemical analysis, and serum UA were measured. Serum UA concentrations were divided into quartiles by sexes. Modified National Cholesterol Education Program Adult Treatment Panel III criteria for Asians were used as diagnosis of MetS. After adjustment, higher UA concentrations are associated with hypertriglyceridemia, low high-density lipoprotein cholesterol level, and high blood pressure in men and with hypertriglyceridemia in women. Significantly higher odds ratios for MetS in the UA third (4.02; 95% confidence interval, 1.33-12.1) and fourth quartiles (9.28; 95% confidence interval, 2.90-29.8) compared with the lowest quartile were found in men but not in women after adjustment. These results suggest that lower UA concentrations in male patients with schizophrenia or schizoaffective disorder are associated with lower risk of MetS.
C1 [Chen, Chun-Hsin; Lu, Mong-Liang] Taipei Med Univ, Wan Fang Hosp, Dept Psychiat, Taipei 116, Taiwan.
   [Chiu, Chih-Chiang; Huang, Ming-Chyi; Chen, Po-Yu; Tsai, Chang-Jer] Taipei City Hosp, Taipei City Psychiat Ctr, Dept Psychiat, Taipei, Taiwan.
   [Chiu, Chih-Chiang; Chen, Chun-Hsin; Huang, Ming-Chyi; Lu, Mong-Liang] Taipei Med Univ, Coll Med, Sch Med, Dept Psychiat, Taipei, Taiwan.
   [Chiu, Chih-Chiang] Kings Coll London, Inst Psychiat, London WC2R 2LS, England.
   [Tsai, Chang-Jer] Natl Chengchi Univ, Inst Neurosci, Taipei 11623, Taiwan.
C3 Taipei Medical University; Taipei Municipal WanFang Hospital; Taipei
   City Hospital; Taipei Medical University; University of London; King's
   College London; National Chengchi University
RP Lu, ML (corresponding author), Taipei Med Univ, Wan Fang Hosp, Dept Psychiat, 111 Section 3,Hsin Long Rd, Taipei 116, Taiwan.
EM mongliang@hotmail.com
RI Huang, Ming-Chyi/W-9515-2019; Chen, Yi-Hsuan/ABF-8054-2020
OI Lu, Mong-Liang/0000-0003-3184-6554
FU Taipei City Government, Taipei Medical University-Wan Fang Hospital
   [101wf-eva-13]; National Science Council [NSC96-2628-B-038-031-MY3,
   NSC98-2314-B-532-001-MY3, NSC99-2314-B-038-020-MY3]; National Health
   Research Institute, Taiwan [NHRI-EX99-9741PI]
FX This study was supported by grants from Taipei City Government, Taipei
   Medical University-Wan Fang Hospital (101wf-eva-13), National Science
   Council (NSC96-2628-B-038-031-MY3, NSC98-2314-B-532-001-MY3, and
   NSC99-2314-B-038-020-MY3), and National Health Research Institute
   (NHRI-EX99-9741PI), Taiwan.
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NR 66
TC 12
Z9 15
U1 0
U2 12
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0271-0749
J9 J CLIN PSYCHOPHARM
JI J. Clin. Psychopharmacol.
PD OCT
PY 2012
VL 32
IS 5
BP 585
EP 592
DI 10.1097/JCP.0b013e3182664e64
PG 8
WC Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Psychiatry
GA 004HI
UT WOS:000308671800002
PM 22926590
DA 2025-06-11
ER

PT J
AU Park, SH
   Lindholm, B
AF Park, Sun-Hee
   Lindholm, Bengt
TI DEFINITION OF METABOLIC SYNDROME IN PERITONEAL DIALYSIS
SO PERITONEAL DIALYSIS INTERNATIONAL
LA English
DT Article; Proceedings Paper
CT 12th Congress of the International-Society-for-Peritoneal-Dialysis
CY JUN 20-24, 2008
CL Istanbul, TURKEY
SP Int Soc Peritoneal Dialysis
DE Metabolic syndrome; chronic kidney disease
ID CHRONIC KIDNEY-DISEASE; STAGE RENAL-DISEASE; INSULIN-RESISTANCE;
   CARDIOVASCULAR-DISEASE; PROVISIONAL REPORT; DIABETES-MELLITUS;
   BODY-COMPOSITION; LIPID-LEVELS; RISK-FACTOR; MORTALITY
AB Metabolic syndrome (MetS) is defined as a cluster of risk factors for type 2 diabetes and cardiovascular disease; it is also an independent risk factor for developing chronic kidney disease (CKD) in the general population. Therefore, CKD has many similarities and associations with MetS, and the individual risk factors constituting MetS-especially insulin resistance and glucose intolerance, hypertension, dyslipidemia, and obesity-are also common features of the early stages of CKD. In the later stages of CKD, uremia per se and uremic complications such as fluid retention, protein-energy wasting, inflammation, and oxidative stress further contribute to an increase in the prevalence of MetS in CKD patients. In addition, PD patients exposed to glucose-based PD fluids have an increased risk of developing metabolic complications. The broad use of MetS in clinical research has raised the awareness of the public and of individual patients concerning the value of lifestyle interventions. However, the definition and pathogenesis of MetS are still debated, and no standardized definition nor proven prognostic value has been established for MetS as a cluster of risk factors for diabetes or cardiovascular disease in PD patients. Furthermore, considering the paradoxical associations of some of the risk factors in MetS with decreased mortality, another set of risk factors-those specific to patients with uremia (for example, inflammation and malnutrition)-and the appropriate cut-off levels to individual MetS risk factors should be taken account at the same time. Also, the benefit of interventions targeting these risk factors should be clarified in further clinical studies.
C1 [Lindholm, Bengt] Karolinska Univ Hosp, Karolinska Inst, Dept Clin Sci Intervent & Technol, Div Baxter Novum & Renal Med, S-14186 Stockholm, Sweden.
C3 Karolinska Institutet; Karolinska University Hospital
RP Lindholm, B (corresponding author), Karolinska Univ Hosp, Karolinska Inst, Dept Clin Sci Intervent & Technol, Div Baxter Novum & Renal Med, K-56, S-14186 Stockholm, Sweden.
EM bengt.lindholm@ki.se
RI Lindholm, Bengt/P-1334-2017
OI Lindholm, Bengt/0000-0003-4269-4293
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NR 63
TC 31
Z9 34
U1 0
U2 2
PU MULTIMED INC
PI TORONTO
PA 66 MARTIN ST, TORONTO, ON L9T 2R2, CANADA
SN 0896-8608
J9 PERITON DIALYSIS INT
JI Perit. Dial. Int.
PD FEB
PY 2009
VL 29
SU 2
BP S137
EP S144
PG 8
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Urology & Nephrology
GA 415ME
UT WOS:000263937100027
PM 19270203
DA 2025-06-11
ER

PT J
AU Mora-Ortiz, M
   Yubero-Serrano, EM
   Priego-Capote, F
   Gutierrez-Mariscal, FM
   Alcala-Diaz, JF
   Torres-Peña, JD
   de-Larriva, APA
   Delgado-Lista, J
   Perez-Martinez, P
   Roche, HM
   López-Miranda, J
AF Mora-Ortiz, Marina
   Yubero-Serrano, Elena M.
   Priego-Capote, Feliciano
   Gutierrez-Mariscal, Francisco M.
   Alcala-Diaz, Juan F.
   Torres-Pena, Jose D.
   de-Larriva, Antonio P. Arenas
   Delgado-Lista, Javier
   Perez-Martinez, Pablo
   Roche, Helen M.
   Lopez-Miranda, Jose
TI Dietary Lipid Quantity and Quality Modulate the Postprandial Metabolomic
   Profile in Patients with Metabolic Syndrome
SO NUTRIENTS
LA English
DT Article
DE metabolic syndrome; metabolomics; SFA; MUFAs; oxidative stress;
   inflammation
ID PARTIAL LEAST-SQUARES; ADIPOSE-TISSUE; LOW-FAT; DEFINITION; STATE; RISK;
   IDENTIFICATION; LIPGENE
AB The literature on the postprandial metabolic changes in individuals with Metabolic Syndrome (MetS) remains limited, despite the fact that postprandial states represent the most common physiological condition in Western societies. Background/Objectives: The objective of this study was to investigate the plasma metabolomics profile in both fasting and postprandial states following a high-fat challenge in individuals with MetS who consumed diets with varying quantities and qualities of dietary fat over 12 weeks. Methods: Seventy-five patients with MetS (28 males and 47 females) from the Spanish LIPGENE cohort were included in the study. MetS patients were randomly stratified to follow one of four dietary interventions (isoenergetic diets) for a 12-week long-term study. The four diets were high in saturated fatty acids and high in monounsaturated fatty acids (HSFA and HMUFA), low-fat high-complex carbohydrates (LFHCC), and LFHCC supplemented with n-3. The metabolomics analysis of plasma samples was carried out using Liquid Chromatography Time-of-Flight Mass Spectrometry (LC-TOF/MS). Results: We observed a decrease in inflammation biomarkers, including acetylcarnitine and L-carnitine during the fasting state and hexanoyl-L-carnitine and isobutyryl-L-carnitine during the postprandial period, mediated by the replacement of HSFA with HMUFA. Additionally, antioxidant compounds such as 4-hydroxybenzaldehyde and L-valine were expressed at higher levels after consumption of the HMUFA diet compared to the HSFA diet. HSFA also presented altered levels of phosphatidylcholine, a metabolite previously linked with insulin resistance. Conclusions: These findings suggest that replacing HSFA with HMUFA may reduce inflammation and improve antioxidant profiles, supporting the potential for tailored dietary interventions in individuals with MetS.
C1 [Mora-Ortiz, Marina; Yubero-Serrano, Elena M.; Gutierrez-Mariscal, Francisco M.; Alcala-Diaz, Juan F.; Torres-Pena, Jose D.; de-Larriva, Antonio P. Arenas; Delgado-Lista, Javier; Perez-Martinez, Pablo; Lopez-Miranda, Jose] Reina Sofia Univ Hosp, Internal Med Unit, Lipids & Atherosclerosis Unit, Cordoba 14004, Spain.
   [Mora-Ortiz, Marina; Yubero-Serrano, Elena M.; Gutierrez-Mariscal, Francisco M.; Alcala-Diaz, Juan F.; Torres-Pena, Jose D.; de-Larriva, Antonio P. Arenas; Delgado-Lista, Javier; Perez-Martinez, Pablo; Lopez-Miranda, Jose] Maimonides Biomed Res Inst Cordoba IMIBIC, Cordoba 14004, Spain.
   [Mora-Ortiz, Marina; Yubero-Serrano, Elena M.; Gutierrez-Mariscal, Francisco M.; Alcala-Diaz, Juan F.; Torres-Pena, Jose D.; de-Larriva, Antonio P. Arenas; Delgado-Lista, Javier; Perez-Martinez, Pablo; Lopez-Miranda, Jose] Univ Cordoba, Dept Med & Surg Sci, Cordoba 14071, Spain.
   [Mora-Ortiz, Marina; Yubero-Serrano, Elena M.; Gutierrez-Mariscal, Francisco M.; Alcala-Diaz, Juan F.; Torres-Pena, Jose D.; de-Larriva, Antonio P. Arenas; Delgado-Lista, Javier; Perez-Martinez, Pablo; Lopez-Miranda, Jose] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr CIBERObn, Madrid 28029, Spain.
   [Yubero-Serrano, Elena M.] CSIC, Dept Food & Hlth, Inst Grasa, Seville 28006, Spain.
   [Priego-Capote, Feliciano] Univ Cordoba, Dept Quim Analit & Nanoquim, Edificio Marie Curie Anexo, Cordoba 14071, Spain.
   [Priego-Capote, Feliciano] Inst Salud Carlos III, CIBER Fragilidad & Envejecimiento Saludable CIBERF, Madrid 28029, Spain.
   [Roche, Helen M.] Univ Coll Dublin, Conway Inst, Sch Publ Hlth, Nutrigen Res Grp, Dublin D04 V1W8, Ireland.
   [Roche, Helen M.] Queens Univ Belfast, Inst Global Food Secur, Belfast BT7 1NN, North Ireland.
C3 Universidad de Cordoba; Instituto de Salud Carlos III; CIBER - Centro de
   Investigacion Biomedica en Red; CIBEROBN; Consejo Superior de
   Investigaciones Cientificas (CSIC); CSIC - Instituto de la Grasa (IG);
   Universidad de Cordoba; Instituto de Salud Carlos III; University
   College Dublin; Queens University Belfast
RP Mora-Ortiz, M; López-Miranda, J (corresponding author), Reina Sofia Univ Hosp, Internal Med Unit, Lipids & Atherosclerosis Unit, Cordoba 14004, Spain.; Mora-Ortiz, M; López-Miranda, J (corresponding author), Maimonides Biomed Res Inst Cordoba IMIBIC, Cordoba 14004, Spain.; Mora-Ortiz, M; López-Miranda, J (corresponding author), Univ Cordoba, Dept Med & Surg Sci, Cordoba 14071, Spain.; Mora-Ortiz, M; López-Miranda, J (corresponding author), Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr CIBERObn, Madrid 28029, Spain.
EM marina.mora@imibic.org; elena.yubero@imibic.org; q72prcaf@uco.es;
   francisco.gutierrez@imibic.org; juanf.alcala.sspa@juntadeandalucia.es;
   h42topej@uco.es; h52arlaa@uco.es; md1delij@uco.es; pablopermar@yahoo.es;
   helen.roche@ucd.ie; jlopezmir@uco.es
RI Delgado-Lista, Javier/KAM-7412-2024; Arenas, Antonio/Y-9969-2019;
   Yubero-Serrano, Elena/H-4832-2013; Gutierrez-Mariscal, Francisco
   M/AAX-3185-2021; Lopez-Miranda, Jose/Y-8306-2019; Alcala-Diaz,
   Juan/Q-4455-2019; Peña, José/ABH-3312-2020; Gutierrez Mariscal,
   Francisco Miguel/F-9804-2016; Priego-Capote, Feliciano/C-7977-2014;
   Perez Martinez, Pablo/AEL-6176-2022
OI Gutierrez Mariscal, Francisco Miguel/0000-0003-3353-2188; Priego-Capote,
   Feliciano/0000-0003-0697-719X; Delgado Lista, Francisco
   Javier/0000-0002-2982-2716; Perez Martinez, Pablo/0000-0001-7716-8117;
   Roche, Helen/0000-0002-0628-3318; Mora-Ortiz, Marina/0000-0002-6662-2932
FU LIPGENE-an EU 6th Framework Program Integrated Project [FOOD-CT- 39
   03-505944]; LIPGENE-an EU; Ministry of Economy and Competitiveness
   [PIE14/000015/5]; Carlos III Institute of Health, Spain; Directorate
   General for Assessment and Promotion of Research; EU's European Regional
   Development Fund; Carlos III Institute of Health, Madrid, Spain
FX The study has been supported by LIPGENE-an EU 6th Framework Program
   Integrated Project (FOOD-CT- 39 03-505944). The study was also
   co-financed by the Ministry of Economy and Competitiveness
   (AGL2012-39615/ALI) and the Carlos III Institute of Health, Spain
   (PIE14/000015/5), and by the Directorate General for Assessment and
   Promotion of Research and the EU's European Regional Development Fund.
   CIBEROBN is an initiative of the Carlos III Institute of Health, Madrid,
   Spain.
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NR 42
TC 0
Z9 0
U1 1
U2 1
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD DEC
PY 2024
VL 16
IS 24
AR 4267
DI 10.3390/nu16244267
PG 16
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA Q4N0B
UT WOS:001384455500001
PM 39770889
OA gold
DA 2025-06-11
ER

PT J
AU Farahani, RA
   Afarideh, M
   Zhu, XY
   Tang, H
   Jordan, KL
   Saadiq, IM
   Ferguson, CM
   Lerman, A
   Textor, SC
   Lerman, LO
   Eirin, A
AF Farahani, Rahele A.
   Afarideh, Mohsen
   Zhu, Xiang-Yang
   Tang, Hui
   Jordan, Kyra L.
   Saadiq, Ishran M.
   Ferguson, Christopher M.
   Lerman, Amir
   Textor, Stephen C.
   Lerman, Lilach O.
   Eirin, Alfonso
TI Percutaneous transluminal renal angioplasty attenuates poststenotic
   kidney mitochondrial damage in pigs with renal artery stenosis and
   metabolic syndrome
SO JOURNAL OF CELLULAR PHYSIOLOGY
LA English
DT Article
DE hypertension; metabolic syndrome; mitochondria; renal artery stenosis;
   renovascular disease; revascularization
ID ATHEROSCLEROTIC RENOVASCULAR DISEASE; GLOMERULAR-FILTRATION; OXIDATIVE
   STRESS; REVASCULARIZATION; PROTECTS; OUTCOMES; MODEL
AB Percutaneous transluminal renal angioplasty (PTRA) has been used to treat renovascular disease (RVD), a chronic condition characterized by renal ischemia and metabolic abnormalities. Mitochondrial injury has been implicated as a central pathogenic mechanism in RVD, but whether it can be reversed by PTRA remains uncertain. We hypothesized that PTRA attenuates mitochondrial damage, renal injury, and dysfunction in pigs with coexisting renal artery stenosis (RAS) and metabolic syndrome (MetS). Four groups of pigs (n = 6 each) were studied after 16 weeks of diet-induced MetS and RAS (MetS + RAS), MetS + RAS treated 4 weeks earlier with PTRA, and Lean and MetS Sham controls. Single-kidney renal blood flow (RBF) and glomerular filtration rate (GFR) were assessed in vivo with multidetector computed tomography, and renal tubular mitochondrial structure and function and renal injury ex vivo. PTRA successfully restored renal artery patency, but mean arterial pressure remained unchanged. Stenotic kidney RBF and GFR, which fell in MetS + RAS compared to MetS, rose after PTRA. PTRA attenuated MetS + RAS-induced mitochondrial structural abnormalities in tubular cells and peritubular capillary endothelial cells, decreased mitochondrial H(2)0(2) production, and increased renal cytochrome-c oxidase-IV activity and ATP production. PTRA also improved cortical microvascular and peritubular capillary density and ameliorated tubular injury and tubulointerstitial fibrosis in the poststenotic kidney. Importantly, renal mitochondrial damage correlated with poststenotic injury and dysfunction. Renal revascularization attenuated mitochondrial injury and improved renal hemodynamics and function in swine poststenotic kidneys. This study suggests a novel mechanism by which PTRA might be relatively effective in ameliorating mitochondrial damage and improving renal function in coexisting MetS and RAS.
C1 [Farahani, Rahele A.; Afarideh, Mohsen; Zhu, Xiang-Yang; Tang, Hui; Jordan, Kyra L.; Saadiq, Ishran M.; Ferguson, Christopher M.; Textor, Stephen C.; Lerman, Lilach O.; Eirin, Alfonso] Mayo Clin, Div Nephrol & Hypertens, Dept Internal Med, 200 First St SW, Rochester, MN 55905 USA.
   [Lerman, Amir] Mayo Clin, Dept Cardiovasc Dis, Rochester, MN 55905 USA.
C3 Mayo Clinic; Mayo Clinic
RP Eirin, A (corresponding author), Mayo Clin, Div Nephrol & Hypertens, Dept Internal Med, 200 First St SW, Rochester, MN 55905 USA.
EM eirinmassat.alfonso@mayo.edu
RI Balakrishnan, Senthilkumar/J-6908-2014; Lerman, Lilach/M-4962-2017;
   Eirin, Alfonso/N-9873-2013
OI Eirin, Alfonso/0000-0002-3864-9644
FU National Institute of Diabetes and Digestive and Kidney Diseases
   [DK102325, DK104273, DK106427, DK120292, DK122137]
FX National Institute of Diabetes and Digestive and Kidney Diseases,
   Grant/Award Numbers: DK102325, DK104273, DK106427, DK120292, DK122137
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NR 38
TC 4
Z9 4
U1 1
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0021-9541
EI 1097-4652
J9 J CELL PHYSIOL
JI J. Cell. Physiol.
PD MAY
PY 2021
VL 236
IS 5
BP 4036
EP 4049
DI 10.1002/jcp.30146
EA NOV 2020
PG 14
WC Cell Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Physiology
GA QO7JN
UT WOS:000585421500001
PM 33151557
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Feng, XM
   Li, LM
   Huang, LL
   Zhang, HY
   Mo, ZN
   Yang, XB
AF Feng, Xiuming
   Li, Longman
   Huang, Lulu
   Zhang, Haiying
   Mo, Zengnan
   Yang, Xiaobo
TI Associations Between Serum Multiple Metals Exposures and Metabolic
   Syndrome: a Longitudinal Cohort Study
SO BIOLOGICAL TRACE ELEMENT RESEARCH
LA English
DT Article
DE Metabolic syndrome; Co-exposure; Cross-sectional analysis; Longitudinal
   cohort analysis
ID HEAVY-METALS; OXIDATIVE STRESS; NATIONAL-HEALTH; DIETARY TIN;
   WHOLE-BLOOD; RISK-FACTOR; ZINC; MEN; MAGNESIUM; MANGANESE
AB Although many studies have confirmed metabolic syndrome (MetS) is correlated with metal exposures, few studies have elucidated the associations of multiple metals with MetS risk. We aim to explore the relationship between serum 22 metals and MetS. We determined serum 22 metals using ICP-MS and used LASSO regression to select metals independently related with MetS to construct multiple-metals model. We further explored the dose-response relationship between positive metals and MetS by the restricted cubic spline regression. After screening by LASSO regression, serum 11 metals were selected to construct multiple-metals model in cross-sectional analysis, while 5 metals in longitudinal analysis. In the 11-metal model, only tin and zinc were associated with MetS in cross-sectional analysis (ORtin= 2.22, 95% CI:1.43, 3.45; ORzinc= 2.17, 95% CI: 1.42, 3.32; bothP(trend)< 0.05). Besides, the same results were found in the 5-metal model in longitudinal analysis (HRtin= 1.66, 95% CI: 0.87, 3.17; HRzinc= 1.83, 95% CI: 1.07, 3.14; bothP(trend)< 0.05). Moreover, there were positive linear relationships between serum tin and zinc concentrations and the increasing risk of MetS (bothP(overall)< 0.05,Pnon-linearity> 0.05). Furthermore, the interaction between high tin and high zinc was also associated with increasing MetS risk (P-interaction< 0.05). We found that serum tin and zinc were independently and interactively associated with MetS in the southern Chinese men. Our results suggested that high tin and zinc may be the risk factors of MetS.
C1 [Feng, Xiuming; Li, Longman; Huang, Lulu; Zhang, Haiying; Mo, Zengnan; Yang, Xiaobo] Guangxi Med Univ, Ctr Genom & Personalized Med, Nanning, Guangxi, Peoples R China.
   [Feng, Xiuming; Li, Longman; Huang, Lulu; Zhang, Haiying; Mo, Zengnan; Yang, Xiaobo] Guangxi Key Lab Genom & Personalized Med, Nanning, Guangxi, Peoples R China.
   [Feng, Xiuming; Li, Longman; Huang, Lulu; Zhang, Haiying; Mo, Zengnan; Yang, Xiaobo] Guangxi Collaborat Innovat Ctr Genom & Personaliz, Nanning, Guangxi, Peoples R China.
   [Feng, Xiuming; Huang, Lulu; Yang, Xiaobo] Guangxi Med Univ, Sch Publ Hlth, Dept Occupat Hlth & Environm Hlth, Nanning, Guangxi, Peoples R China.
   [Mo, Zengnan] Guangxi Med Univ, Affiliated Hosp 1, Inst Urol & Nephrol, Nanning, Guangxi, Peoples R China.
C3 Guangxi Medical University; Guangxi Medical University; Guangxi Medical
   University
RP Feng, XM (corresponding author), Guangxi Med Univ, Ctr Genom & Personalized Med, Nanning, Guangxi, Peoples R China.; Feng, XM (corresponding author), Guangxi Key Lab Genom & Personalized Med, Nanning, Guangxi, Peoples R China.; Feng, XM (corresponding author), Guangxi Collaborat Innovat Ctr Genom & Personaliz, Nanning, Guangxi, Peoples R China.; Feng, XM (corresponding author), Guangxi Med Univ, Sch Publ Hlth, Dept Occupat Hlth & Environm Hlth, Nanning, Guangxi, Peoples R China.
EM fengxiuming@stu.gxmu.edu.cn; lilongman@stu.gxmu.edu.cn;
   luluhuang@gxmu.edu.cn; zhanghaiying@gxmu.edu.cn; zengnanmo@hotmail.com;
   yangx@gxmu.edu.cn
RI Feng, Xiuming/GSN-4262-2022; Yang, Xiaobo/AAD-6333-2019
OI mo, zengnan/0000-0002-3047-3138
FU Guangxi Natural Science Fund for Innovation Research Team
   [2017GXNSFGA198003, 2013GXNSFFA019002]; Program for New Century
   Excellent Talents in University [NCET-12-0653]; Guangxi key Laboratory
   for Genomic and Personalized Medicine [19-050-22, 20-065-33]
FX This work was supported by the Guangxi Natural Science Fund for
   Innovation Research Team [grant numbers 2017GXNSFGA198003,
   2013GXNSFFA019002]; the Program for New Century Excellent Talents in
   University [grant number NCET-12-0653]; and the Guangxi key Laboratory
   for Genomic and Personalized Medicine [grant numbers 19-050-22,
   20-065-33].
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NR 48
TC 13
Z9 14
U1 0
U2 23
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0163-4984
EI 1559-0720
J9 BIOL TRACE ELEM RES
JI Biol. Trace Elem. Res.
PD JUL
PY 2021
VL 199
IS 7
BP 2444
EP 2455
DI 10.1007/s12011-020-02371-w
EA OCT 2020
PG 12
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA SU8CK
UT WOS:000574802900001
PM 33009983
DA 2025-06-11
ER

PT J
AU Palomäki, A
   Pohjantähti-Maaroos, H
   Wallenius, M
   Kankkunen, P
   Aro, H
   Husgafvel, S
   Pihlava, JM
   Oksanen, K
AF Palomaki, Ari
   Pohjantahti-Maaroos, Hanna
   Wallenius, Marja
   Kankkunen, Paivi
   Aro, Heikki
   Husgafvel, Sari
   Pihlava, Juha-Matti
   Oksanen, Kalevi
TI Effects of dietary cold-pressed turnip rapeseed oil and butter on serum
   lipids, oxidized LDL and arterial elasticity in men with metabolic
   syndrome
SO LIPIDS IN HEALTH AND DISEASE
LA English
DT Article
ID LOW-DENSITY-LIPOPROTEIN; CORONARY-HEART-DISEASE; POSTPRANDIAL OXIDATIVE
   STRESS; MEDITERRANEAN DIET; MYOCARDIAL-INFARCTION; RISK-FACTORS;
   FATTY-ACIDS; HEALTHY; GLUCOSE; SUSCEPTIBILITY
AB Background: Rapeseed oil is the principal dietary source of monounsaturated and n-3 polyunsaturated fatty acids in the Northern Europe. However, the effect of rapeseed oil on the markers of subclinical atherosclerosis is not known. The purpose of this study was to compare the effects of dietary intake of cold-pressed turnip rapeseed oil (CPTRO) and butter on serum lipids, oxidized LDL and arterial elasticity in men with metabolic syndrome.
   Methods: Thirty-seven men with metabolic syndrome completed an open and balanced crossover study. Treatment periods lasted for 6 to 8 weeks and they were separated from each other with an eight-week washout period. Subjects maintained their normal dietary habits and physical activity without major variations. The daily fat adjunct consisted either of 37.5 grams of butter or 35 mL of Virgino(R) CPTRO. Participants were asked to spread butter on bread on the butter period and to drink CPTRO on the oil period. The fat adjunct was used as such without heating or frying.
   Results: Compared to butter, administration of CPTRO was followed by a reduction of total cholesterol by 8% (p < 0.001) and LDL cholesterol by 11% (p < 0.001). The level of oxidized LDL was 16% lower after oil period (p = 0.024). Minimal differences in arterial elasticity were not statistically significant.
   Conclusion: Cold-pressed turnip rapeseed oil had favourable effects on circulating LDL cholesterol and oxidized LDL, which may be important in the management of patients at high cardiovascular risk.
C1 [Palomaki, Ari; Pohjantahti-Maaroos, Hanna; Wallenius, Marja; Kankkunen, Paivi; Husgafvel, Sari; Oksanen, Kalevi] Kanta Hame Cent Hosp, FI-13530 Hameenlinna, Finland.
   [Palomaki, Ari; Pohjantahti-Maaroos, Hanna; Wallenius, Marja] Linnan Klin, FI-13100 Hameenlinna, Finland.
   [Pohjantahti-Maaroos, Hanna] Kuopio Univ Hosp, Ctr Heart, FI-70211 Kuopio, Finland.
   [Wallenius, Marja] Mehilainen, FI-13100 Hameenlinna, Finland.
   [Kankkunen, Paivi] Finnish Inst Occupat Hlth, FI-00250 Helsinki, Finland.
   [Aro, Heikki; Pihlava, Juha-Matti] MTT Agrifood Res Finland, FI-31600 Jokioinen, Finland.
   [Aro, Heikki] Finnish Funding Agcy Technol & Innovat, FI-00101 Helsinki, Finland.
C3 Kuopio University Hospital; University of Eastern Finland; University of
   Eastern Finland Hospital; Finnish Institute of Occupational Health;
   Natural Resources Institute Finland (Luke); Finnish Funding Agency for
   Technology & Innovation (TEKES)
RP Pohjantähti-Maaroos, H (corresponding author), Kanta Hame Cent Hosp, Ahvenistontie 20, FI-13530 Hameenlinna, Finland.
EM hanna.pohjantahti-maaroos@kuh.fi
OI Palomaki, Ari/0000-0001-9759-4332; Pihlava,
   Juha-Matti/0000-0002-2404-6789
FU Ministry of Health and Social Welfare in Finland through Kanta-Hame
   Central Hospital; Finnish Cultural Foundation; Kankaisten Oljykasvit
   Ltd; Hilkka and Vaino Kiltti Foundation
FX This study was supported by grants from the Ministry of Health and
   Social Welfare in Finland through the Medical Research Fund of
   Kanta-Hame Central Hospital, the Hame Regional Fund under the auspices
   of the Finnish Cultural Foundation, Kankaisten Oljykasvit Ltd, and
   Hilkka and Vaino Kiltti Foundation. None of them had a role in data
   collection, analysis of the results, or preparation of the manuscript.
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NR 49
TC 23
Z9 25
U1 0
U2 15
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1476-511X
J9 LIPIDS HEALTH DIS
JI Lipids Health Dis.
PD DEC 1
PY 2010
VL 9
AR 137
DI 10.1186/1476-511X-9-137
PG 8
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA 703VW
UT WOS:000286010400001
PM 21122147
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Thauerer, B
   Tóth, AO
   Salzer, A
   Steinecker-Frohnwieser, B
AF Thauerer, Bettina
   Toth, Anna Odrovicsne
   Salzer, Andreas
   Steinecker-Frohnwieser, Bibiane
TI Success of an Inpatient Rehabilitation Program in Subjects with Type 2
   Diabetes Mellitus with or Without Metabolic Syndrome
SO BIOMOLECULES
LA English
DT Article
DE type 2 diabetes mellitus (T2DM); metabolic syndrome (MetS); advanced
   glycation end products (AGEs); soluble receptor for AGE (sRAGE); lipid
   metabolism; oxidative stress; prediction model; rehabilitation outcome
ID SERUM URIC-ACID; GLYCATION END-PRODUCTS; DISEASE; MEN
AB Introduction: Type 2 diabetes mellitus (T2DM) comprises heterogeneous disorders, which have an increase in blood glucose concentrations in common. Metabolic syndrome (MetS) describes the simultaneous occurrence of several clinical symptoms that increase the risk of cardiovascular disease and T2DM, although T2DM itself is also considered a risk factor for developing MetS. Objective: This study aimed to identify parameters related to rehabilitation success and relevant to MetS in T2DM patients. Methods: T2DM patients were divided into two subgroups based on the NHLBI/AHA and IDF guidelines for characterizing MetS. Serum samples were analyzed for T2DM-specific parameters, lipid metabolism, oxidative processes, AGE activity (AAct), and uric acid to HDL ratio (UHR) at admission and discharge after a 3-week inpatient rehabilitation stay. Logistic regression and before-after comparisons were performed showing the importance of multidisciplinary rehabilitation. Results: Among eighty-six patients, 59.3% had MetS. Significant differences between subgroups were found in fasting glucose (FBS), hemoglobin A1c (HbA1c), high-density lipoprotein cholesterol (HDL), triglycerides (TGLs), soluble receptor for AGE (sRAGE), UHR, and AAct. Rehabilitation-induced changes in disease-related parameters were influenced by the presence of MetS. The predictive capacity from all parameters together could be reduced within the three weeks. Conclusion: Rehabilitative measures have a major influence on MetS-relevant factors and can change the course of the disease in patients with T2DM. Identifying these factors can be of great importance for future diagnoses and treatments of T2DM and MetS.
C1 [Thauerer, Bettina; Toth, Anna Odrovicsne; Steinecker-Frohnwieser, Bibiane] Ludwig Boltzmann Inst Arthrit & Rehabil, A-5760 Saalfelden, Austria.
   [Salzer, Andreas] Rehabil Ctr Saalfelden Pens Insurance Inst, A-5760 Saalfelden, Austria.
   [Steinecker-Frohnwieser, Bibiane] Ludwig Boltzmann Inst Arthrit & Rehabil, A-8962 Grobming, Austria.
RP Thauerer, B; Steinecker-Frohnwieser, B (corresponding author), Ludwig Boltzmann Inst Arthrit & Rehabil, A-5760 Saalfelden, Austria.; Steinecker-Frohnwieser, B (corresponding author), Ludwig Boltzmann Inst Arthrit & Rehabil, A-8962 Grobming, Austria.
EM bettina.thauerer@ar.lbg.ac.at; anna.odrovicsne-toth@ar.lbg.ac.at;
   andreas.salzer@pv.at; bibiane.steinecker-frohnwieser@ar.lbg.ac.at
FU Ludwig Boltzmann Institute for Arthritis and Rehabilitation
FX This research received no external funding. The APC was funded by the
   Ludwig Boltzmann Institute for Arthritis and Rehabilitation.
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NR 37
TC 0
Z9 0
U1 0
U2 0
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2218-273X
J9 BIOMOLECULES
JI Biomolecules
PD DEC
PY 2024
VL 14
IS 12
AR 1527
DI 10.3390/biom14121527
PG 13
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA Q8F5V
UT WOS:001386968900001
PM 39766234
OA gold
DA 2025-06-11
ER

PT J
AU Farag, AGA
   Badr, EAE
   El-Shafey, AESS
   Elshaib, ME
AF Farag, Azza Gaber Antar
   Badr, Eman A. E.
   El-Shafey, Asmaa El-Shafey Soliman
   Elshaib, Mustafa Elsayed
TI Fatty acid-binding protein 4 circulating levels in non-segmental
   vitiligo
SO ANAIS BRASILEIROS DE DERMATOLOGIA
LA English
DT Article
DE Fatty acid-binding proteins; Metabolic syndrome; Vitiligo
ID METABOLIC SYNDROME; OXIDATIVE STRESS; BIOMARKER; FABP4; EXPRESSION
AB Background: Vitiligo is an acquired and progressive mucocutaneous disease resulting from the loss of active epidermal melanocytes. Metabolic syndrome (MetS) affects about 25% of the world's population and is linked to inflammatory skin diseases including vitiligo. Fatty Acid Binding Protein 4 (FABP4) is an intracellular lipid chaperone. FABP4 is closely associated with MetS.
   Objectives: To evaluate the serum level of FABP4 in vitiligo patients and its relation to MetS in the investigated cases.
   Methods: This case control study was conducted on 45 patients having non segmental vitiligo and 45 matched controls. Their lipid profile, blood glucose and serum FABP4 levels were measured.
   Results: There were significant elevations in FABP4 (p < 0.001), cholesterol (p < 0.001), triglycerides (p = 0.005), and glucose (fasting [p = 0.001] and 2 hours post prandial [p < 0.001]) levels in patients in comparison with controls. MetS was significantly more prevalent among vitiligo patients (p < 0.001) and associated with high FABP4 serum levels (p = 0.037). In vitiligo patients, there were significant positive correlations between FABP4 serum levels and triglycerides (p = 0.047), cholesterol (p = 0.001) and LDL (p = 0.001) levels and negative correlation regarding HDL level (p = 0.009). FABP4 level was a significantly good diagnostic test for early detection of vitiligo (p < 0.001).
   Study limitations: The small number of studied subjects.
   Conclusions: FABP4 may play an active role in the disease process of vitiligo that could be mediated through associated dyslipidemia and hyperglycemia. FABP4 may be a marker of vitiligo helping in its early diagnosis, but it does not appear to be useful for determining vitiligo severity, activity or associated MetS. (C) 2021 Sociedade Brasileira de Dermatologia. Published by Elsevier Espana, S.L.U.
C1 [Farag, Azza Gaber Antar] Menoufia Univ, Fac Med, Androl & STDs, Shebin Alkom, Egypt.
   [Badr, Eman A. E.] Menoufia Univ, Fac Med, Med Biochem & Mol Biol Dept, Shebin Alkom, Egypt.
   [El-Shafey, Asmaa El-Shafey Soliman] Minist Hlth, Gen Hosp, Dermatol, Shebin Alkom, Egypt.
   [Elshaib, Mustafa Elsayed] Menoufia Univ, Fac Med, Shebin Alkom, Egypt.
C3 Egyptian Knowledge Bank (EKB); Menofia University; Egyptian Knowledge
   Bank (EKB); Menofia University; Egyptian Knowledge Bank (EKB); Ministry
   of Health & Population - Egypt; Egyptian Knowledge Bank (EKB); Menofia
   University
RP Farag, AGA (corresponding author), Menoufia Univ, Fac Med, Androl & STDs, Shebin Alkom, Egypt.
EM azzagaber92@yahoo.com
RI badr, eman/AAA-6718-2021
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NR 35
TC 6
Z9 6
U1 0
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0365-0596
EI 1806-4841
J9 AN BRAS DERMATOL
JI An. Brasil. Dermatol.
PD JAN-FEB
PY 2022
VL 97
IS 1
BP 28
EP 36
DI 10.1016/j.abd.2021.04.014
EA JAN 2022
PG 9
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA YP6FI
UT WOS:000748717000004
PM 34839983
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Abood, SJ
   Abdulsahib, WK
   Hussain, SA
   Ismail, SH
AF Abood, Sattar J.
   Abdulsahib, Waleed K.
   Hussain, Saad A.
   Ismail, Sajida H.
TI Melatonin Potentiates the Therapeutic Effects of Metformin in Women with
   Metabolic Syndrome
SO SCIENTIA PHARMACEUTICA
LA English
DT Article
DE melatonin; metformin; metabolic syndrome
ID INSULIN; LEPTIN; ACTIVATION; ADIPOSITY; PROTEIN; STRESS; WEIGHT
AB Objective: This study evaluated the effect of melatonin on the response of patients suffering from metabolic syndrome (MEBS) treated with metformin. Design: This study used two-armed groups in a double-blind, randomized controlled clinical trial. Materials and Methods: A randomized double-blind placebo-controlled study was carried out on female patients diagnosed as having MEBS, according to the International Diabetes Federation (IDF) diagnosing criteria of MEBS (2005), from the outpatient clinic in Al-Zahraa Teaching Hospital/Kut, Iraq. They were diagnosed utilizing laboratory and clinical investigations, then randomized into two groups. The first group (group A) was treated with metformin (500 mg) twice daily, in addition to a placebo formula once daily at bedtime for three months. The second group (group B) was treated with metformin (500 mg) twice daily after meals, in addition to melatonin (10 mg) once daily at bedtime for three months. Results: The treatment of patients with MEBS using metformin-melatonin showed an improvement in most MEBS components such as fasting serum glucose (FSG), lipid profile, and body mass index (BMI), in addition to a reduction in insulin resistance and hyperinsulinemia. Simultaneously, there were increments in serum uric acid (UA), leptin, prolactin (PRL), and estradiol levels, while serum progesterone level decreased. Furthermore, patients treated with metformin-placebo showed less improvement in the studied parameters compared to that produced due to the inclusion of melatonin in the treatment protocol. Conclusion: Melatonin improves the effect of metformin on several components of MEBS such as FSG, lipid profile, and BMI, in addition to insulin resistance and hyperinsulinemia, compared to metformin alone.
C1 [Abood, Sattar J.; Abdulsahib, Waleed K.] Al Farahidi Univ, Coll Pharm, Dept Pharmacol & Toxicol, Baghdad 10070, Iraq.
   [Hussain, Saad A.] Al Rafidain Univ Coll, Fac Pharm, Baghdad 10064, Iraq.
   [Ismail, Sajida H.] Univ Baghdad, Coll Pharm, Baghdad 10047, Iraq.
C3 Al-Farahidi University; University of Baghdad
RP Abdulsahib, WK (corresponding author), Al Farahidi Univ, Coll Pharm, Dept Pharmacol & Toxicol, Baghdad 10070, Iraq.
EM lokmas14@gmail.com; waleed.abdelsahib@alfarahidiuc.edu.iq;
   saad_alzaidi@yahoo.com; sajidahusain63@yahoo.com
RI Hussain, Saad/L-1237-2017; Al-Hussein, Sattar/ABA-6007-2020; ismael,
   sajida/GNP-0479-2022; Abdulsahib, Waleed K/AAY-9263-2020
OI Al- Hussein, Dr.Sattar/0000-0002-7824-9549; Abdulsahib, Waleed
   K/0000-0002-8851-5783; hussein, sajidah/0000-0001-8490-8136
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NR 37
TC 11
Z9 11
U1 0
U2 4
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2218-0532
J9 SCI PHARM
JI Sci. Pharm.
PY 2020
VL 88
IS 2
AR 28
DI 10.3390/scipharm88020028
PG 14
WC Pharmacology & Pharmacy
WE Emerging Sources Citation Index (ESCI)
SC Pharmacology & Pharmacy
GA MN9KO
UT WOS:000551158800002
OA gold
DA 2025-06-11
ER

PT J
AU Li, P
   He, L
   Bin Chen, Z
   Luan, QX
AF Li, Peng
   He, Lu
   Bin Chen, Zhi
   Luan, Qing Xian
TI Biomarkers in Metabolic Syndrome Patients with Chronic Periodontitis
SO CHINESE JOURNAL OF DENTAL RESEARCH
LA English
DT Article
DE cytokines; inflammation; metabolic syndrome; periodontitis
ID C-REACTIVE PROTEIN; OXIDATIVE STRESS; MARKERS; SERUM; ASSOCIATION;
   CYTOKINES; DISEASE; HEALTH
AB Objectives: To investigate whether the levels of serum C-reactive protein (CRP), salivary interleukin (IL)-6 and IL-1 beta in metabolic syndrome (MS) patients can be potential monitors for inflammation in MS patients with severe periodontitis.
   Methods: A total of 114 MS patients and 49 systemically healthy subjects were enrolled. CRP in serum and IL-1 beta and IL-6 in non-stimulated whole saliva were collected from these patients and subjects and analysed by enzyme-linked immunosorbent assay (ELISA). Dental examinations were performed and the participants completed a questionnaire.
   Results: The serum CRP level of MS patients was higher than that of systemically healthy subjects, and increased as the number of components increased (P < 0.05). No difference was observed in the salivary level of IL-6 and IL-1 beta between MS patients and controls or between MS patients with different components. The level of salivary IL-6 in MS patients with moderate/severe periodontitis was significantly higher than in MS patients with good periodontal health/mild periodontitis (P < 0.05). After adjustment for age, sex and smoking habits, multivariate analysis showed that the corresponding odds ratio (OR) for MS combined with moderate/severe periodontitis was 1.21 (95% confidence interval [CI] 1.04-1.39, P = 0.012) for subjects with high serum CRP and salivary IL-6 and IL-1 beta were not risk indicators for MS combined with moderate/severe periodontitis.
   Conclusions: MS patients might be burdened by high levels of serum CRP. Serum CRP could be a potentially valuable biomarker to detect inflammation in MS patients with severe periodontal disease.
C1 [Li, Peng] Peking Univ, Dent Ctr 2, Natl Engn Lab Digital & Mat Technol Stomatol, Beijing Key Lab Digital Stomatol,Sch & Hosp Stoma, Beijing, Peoples R China.
   [He, Lu; Bin Chen, Zhi; Luan, Qing Xian] Peking Univ, Dept Periodontol, Sch & Hosp Stomatol, Beijing, Peoples R China.
C3 Peking University; Peking University
RP Li, P (corresponding author), Peking Univ, Dent Ctr 2, Sch & Hosp Stomatol, B5 Anli Garden,66 Anli Rd, Beijing 100101, Peoples R China.
EM kqlipeng05420533@sina.com
RI peng, li/GQO-9368-2022
FU Chinese National Key Science and Technology Project from the 'Eleventh
   Five-Year Plan' [2007BAI18B02]; National Nature Science Foundation of
   China [81200784]
FX This investigation was supported by the Chinese National Key Science and
   Technology Project from the 'Eleventh Five-Year Plan' (2007BAI18B02) and
   funded in part by the National Nature Science Foundation of China (Grant
   number 81200784).
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NR 26
TC 3
Z9 3
U1 0
U2 6
PU QUINTESSENCE PUBLISHING CO INC
PI HANOVER PARK
PA 4350 CHANDLER DRIVE, HANOVER PARK, IL 60133 USA
SN 1462-6446
EI 1867-5646
J9 CHIN J DENT RES
JI Chin. J. Dent. Res.
PY 2020
VL 23
IS 3
BP 191
EP 197
DI 10.3290/j.cjdr.a45223
PG 7
WC Dentistry, Oral Surgery & Medicine
WE Emerging Sources Citation Index (ESCI)
SC Dentistry, Oral Surgery & Medicine
GA NX6LI
UT WOS:000575819900004
PM 32974619
DA 2025-06-11
ER

PT J
AU Gheita, TA
   Kenawy, SAB
   El Sisi, RW
   Gheita, HA
   Khalil, H
AF Gheita, Tamer Atef
   Kenawy, Sanaa Abdel Baky
   El Sisi, Rehab Wafik
   Gheita, Heba Atef
   Khalil, Hossam
TI Subclinical reduced G6PD activity in rheumatoid arthritis and Sjogren's
   Syndrome patients: Relation to clinical characteristics, disease
   activity and metabolic syndrome
SO MODERN RHEUMATOLOGY
LA English
DT Article
DE DAS28; G6PD activity; Metabolic syndrome; Rheumatoid arthritis;
   Sjogren's Syndrome
ID GLUCOSE-6-PHOSPHATE-DEHYDROGENASE DEFICIENCY; OXIDATIVE STRESS;
   CLASSIFICATION CRITERIA; GENETIC ABNORMALITIES; RISK; FREQUENCY
AB Objective. Glucose-6-phosphate dehydrogenase (G6PD) is an important site of metabolic control in the pentose phosphate pathway. The purpose of this study was to investigate the enzyme activity of G6PD in Rheumatoid Arthritis (RA) and Sjogren's Syndrome (SS) patients not known to be deficient in this enzyme. It was also within the scope of the aim to find the relation of G6PD to the presence of metabolic syndrome (MetS) in these patients.
   Methods. Erythrocyte G6PD activity was evaluated in 40 RA patients, 30 SS patients and in 30 age- and sex-matched control. The clinical characteristics, disease activity score (DAS28), SS disease activity (SSDAI) and damage (SSDDI) indices and presence of MetS of the included patients were analyzed in relation to the enzyme level.
   Results. The G6PD activity in RA patients (7.72 +/- 3.57 U/g Hb) was significantly reduced compared to that in the SS patients (11.55 +/- 3.14 U/g Hb) and control (13.23 +/- 3.34 U/g Hb) especially those with MetS (4.61 +/- 1.84 U/g Hb) (p < 0.001). There was a significant negative correlation of the G6PD activity with the disease duration and DAS28 (p < 0.001).
   Conclusion. The results of this study, suggest that G6PD not only does not protect against MetS in RA, but may even be considered a risk factor for the development of this disorder. The identification of regulatory tools for G6PD activity may prove promising for treating the associated metabolic disorders and chronic inflammation in RA.
C1 [Gheita, Tamer Atef] Cairo Univ, Fac Med, Dept Rheumatol, Giza 12613, Egypt.
   [Kenawy, Sanaa Abdel Baky] Cairo Univ, Fac Med, Dept Pharmacol, Giza 12613, Egypt.
   [El Sisi, Rehab Wafik] Cairo Univ, Fac Oral & Dent Med, Giza 12613, Egypt.
   [Gheita, Heba Atef] Atom Energy Authorizat, Dept Pharmacol, Cairo, Egypt.
   [Khalil, Hossam] Beni Sweif Univ, Fac Med, Dept Ophthalmol, Beni Sweif, Egypt.
C3 Egyptian Knowledge Bank (EKB); Cairo University; Egyptian Knowledge Bank
   (EKB); Cairo University; Egyptian Knowledge Bank (EKB); Cairo
   University; Egyptian Knowledge Bank (EKB); Egyptian Atomic Energy
   Authority (EAEA); Egyptian Knowledge Bank (EKB); Beni Suef University
RP Gheita, TA (corresponding author), Cairo Univ, Fac Med, Dept Rheumatol, POB 12611,Gamaa St, Giza 12613, Egypt.
EM gheitamer@hotmail.com
RI Gheita, Tamer/HHC-8095-2022
OI A Gheita, Tamer/0000-0002-1155-9729; Gheita, Heba/0000-0002-5782-2908
CR Aletaha D, 2010, ARTHRITIS RHEUM-US, V62, P2569, DOI 10.1002/art.27584
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NR 40
TC 34
Z9 34
U1 0
U2 2
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1439-7595
EI 1439-7609
J9 MOD RHEUMATOL
JI Mod. Rheumatol.
PD JUL
PY 2014
VL 24
IS 4
BP 612
EP 617
DI 10.3109/14397595.2013.851639
PG 6
WC Rheumatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Rheumatology
GA AK7VT
UT WOS:000338636500011
PM 24252052
DA 2025-06-11
ER

PT J
AU Younossi, ZM
AF Younossi, Z. M.
TI Review article: current management of non-alcoholic fatty liver disease
   and non-alcoholic steatohepatitis
SO ALIMENTARY PHARMACOLOGY & THERAPEUTICS
LA English
DT Review
ID CHRONIC HEPATITIS-C; VITAMIN-E TREATMENT; URSODEOXYCHOLIC ACID;
   CONTROLLED-TRIAL; UNITED-STATES; RISK-FACTORS; TRANSIENT ELASTOGRAPHY;
   OVERWEIGHT PATIENTS; METABOLIC SYNDROME; BARIATRIC SURGERY
AB Background
   Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic syndrome.
   Aim
   To assess the epidemiological impact and the current management of patients with NAFLD.
   Methods
   Published peer-reviewed literature and abstracts concerning NAFLD and non-alcoholic steatohepatitis (NASH) were reviewed. Articles specifically related to epidemiology, diagnosis and current treatment strategies for NAFLD and NASH are summarized.
   Results
   NAFLD is strongly associated with the epidemic of obesity and type-2 diabetes mellitus, and is estimated to affect about 20-30% of the population in the US. From the spectrum of NAFLD, only patients with biopsy-proven NASH (estimated prevalence in the US population is about 3-5%) have been convincingly shown to progress to cirrhosis, liver failure and hepatocellular carcinoma. The clinical manifestation of NAFLD is usually absent or subtle, with abnormal aminotransferases or incidental radiographic findings of fatty liver. The pathogenesis of NAFLD is attributed to a multi-hit process involving insulin resistance, oxidative stress, apoptotic pathways, and adipocytokines. In 2008, there is no established treatment for NAFLD. Weight loss and treatment for each component of metabolic syndrome. Nevertheless, a large number of agents are being considered in clinical trials of patients with NASH.
   Conclusions
   Awareness of the tremendous impact of NAFLD as an important cause of chronic liver disease is increasing along with a great deal of information about its pathogenesis. Future, well-designed clinical trials that target specific pathways involved in the pathogenesis of NASH are urgently needed.
C1 Inova Fairfax Hosp, Ctr Liver Dis, Falls Church, VA USA.
C3 Inova Fairfax Hospital
RP Younossi, ZM (corresponding author), Inova Fairfax Hosp, Ctr Liver Dis, 3300 Gallows Rd, Falls Church, VA USA.
EM Zobair.younossi@inova.org
RI Younossi, Zobair M./JRY-9916-2023
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NR 101
TC 128
Z9 147
U1 0
U2 15
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0269-2813
EI 1365-2036
J9 ALIMENT PHARM THER
JI Aliment. Pharmacol. Ther.
PD JUL 1
PY 2008
VL 28
IS 1
BP 2
EP 12
DI 10.1111/j.1365-2036.2008.03710.x
PG 11
WC Gastroenterology & Hepatology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Pharmacology & Pharmacy
GA 308MT
UT WOS:000256395400001
PM 18410557
OA Bronze
DA 2025-06-11
ER

PT J
AU Swartz, HA
   Rucci, P
   Thase, ME
   Wallace, M
   Carretta, E
   Celedonia, KL
   Frank, E
AF Swartz, Holly A.
   Rucci, Paola
   Thase, Michael E.
   Wallace, Meredith
   Carretta, Elisa
   Celedonia, Karen L.
   Frank, Ellen
TI Psychotherapy Alone and Combined With Medication as Treatments for
   Bipolar II Depression: A Randomized Controlled Trial
SO JOURNAL OF CLINICAL PSYCHIATRY
LA English
DT Article
ID METABOLIC SYNDROME; RATING-SCALE; DISORDER; SCHIZOPHRENIA; RELIABILITY;
   QUETIAPINE; SPECTRUM; RISK; ANTIPSYCHOTICS; MONOTHERAPY
AB Objective: Bipolar II disorder (BP-II) is associated with marked morbidity and mortality. Quetiapine, the treatment with greatest evidence for efficacy in BP-II depression, is associated with metabolic burden. Psychotherapy, a treatment with few side effects, has not been systematically evaluated in BP-II. This study compared psychotherapy plus placebo to psychotherapy plus pharmacotherapy as treatments for BP-II depression.
   Methods: From 2010 to 2015, unmedicated adults (n = 92) with DSM-IV-TR BP-II depression were randomly assigned to weekly sessions of Interpersonal and Social Rhythm Therapy (IPSRT) plus placebo or IPSRT plus quetiapine and followed for 20 weeks.
   Results: For primary outcomes, IPSRT + quetiapine yielded significantly faster improvement on 17-item Hamilton Depression Rating Scale (F-1,F-115.4 = 3.924, P = .048) and greater improvement on Young Mania Rating Scale (F-58.5 = 4.242, P = .044) scores. Both groups, however, improved significantly over time with comparable response rates (>= 50% reduction in depression scores): 67.4% (62/92) in the entire sample, with no between-group differences. Those randomly assigned to their preferred treatment were 4.5 times more likely to respond (OR = 4.48, 95% CI = 1.20-16.77, P = .026). IPSRT + quetiapine assignment was associated with significantly higher body mass index over time (F-67.96 = 6.671, P = .012) and rates of dry mouth (79% v. 58%; chi(2) = 4.0, P = .046) and a trend toward more complaints of oversedation (100% vs 92%; chi(2) = 3.4, P = .063).
   Conclusions: IPSRT plus quetiapine resulted in greater symptomatic improvement but also more side effects than IPSRT alone. A subset of participants improved with IPSRT alone, although absence of an inactive comparator limits interpretation of this finding. Receipt of preferred treatment was associated with better outcomes. Harms, benefits, and preferences should be considered when recommending treatments for BP-II depression.
C1 [Swartz, Holly A.; Wallace, Meredith; Celedonia, Karen L.; Frank, Ellen] Univ Pittsburgh, Dept Psychiat, Sch Med, Pittsburgh, PA USA.
   [Rucci, Paola; Carretta, Elisa] Univ Bologna, Dept Biomed & Neuromotor Sci, Bologna, Italy.
   [Thase, Michael E.] Univ Penn, Sch Med, Dept Psychiat, Philadelphia, PA 19104 USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE); University
   of Pittsburgh; University of Bologna; University of Pennsylvania
RP Swartz, HA (corresponding author), 3811 OHara St, Pittsburgh, PA 15213 USA.
EM swartzha@upmc.edu
RI Swartz, Holly/G-5887-2012; Wallace, Meredith/LXV-0747-2024
OI Rucci, Paola/0000-0002-7704-0831; Swartz, Holly/0000-0002-7611-9900
FU National Institute of Mental Health (NIMH) [R01 MH084831]
FX This study was funded by the National Institute of Mental Health (NIMH)
   R01 MH084831 (Dr Swartz, principal investigator).
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NR 48
TC 27
Z9 30
U1 1
U2 25
PU PHYSICIANS POSTGRADUATE PRESS
PI MEMPHIS
PA P O BOX 752870, MEMPHIS, TN 38175-2870 USA
SN 0160-6689
EI 1555-2101
J9 J CLIN PSYCHIAT
JI J. Clin. Psychiatry
PD MAR-APR
PY 2018
VL 79
IS 2
BP 7
EP +
AR 16m11027
DI 10.4088/JCP.16m11027
PG 13
WC Psychology, Clinical; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA GK7NE
UT WOS:000436392200030
PM 28703949
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Ozdemir, AC
   Wynn, GM
   Vester, A
   Weitzmann, MN
   Neigh, GN
   Srinivasan, S
   Rudd, MK
AF Ozdemir, Alev Cagla
   Wynn, Grace M.
   Vester, Aimee
   Weitzmann, M. Neale
   Neigh, Gretchen N.
   Srinivasan, Shanthi
   Rudd, M. Katharine
TI GNB3 overexpression causes obesity and metabolic syndrome
SO PLOS ONE
LA English
DT Article
ID WHITE ADIPOSE-TISSUE; BROWN ADIPOCYTES; OPEN-FIELD; SOCIAL-INTERACTION;
   MOLECULAR-BASIS; GAMMA-SUBUNITS; BODY-WEIGHT; G-PROTEINS; MICE; FAT
AB The G-protein beta subunit 3 (GNB3) gene has been implicated in obesity risk; however, the molecular mechanism of GNB3-related disease is unknown. GNB3 duplication is responsible for a syndromic form of childhood obesity, and an activating DNA sequence variant (C825T) in GNB3 is also associated with obesity. To test the hypothesis that GNB3 overexpression causes obesity, we created bacterial artificial chromosome (BAC) transgenic mice that carry an extra copy of the human GNB3 risk allele. Here we show that GNB3-T/+ mice have increased adiposity, but not greater food intake or a defect in satiety. GNB3-T/+ mice have elevated fasting plasma glucose, insulin, and C-peptide, as well as glucose intolerance, indicating type 2 diabetes. Fasting plasma leptin, triglycerides, cholesterol and phospholipids are elevated, suggesting metabolic syndrome. Based on a battery of behavioral tests, GNB3-T/+ mice did not exhibit anxiety-or depressive-like phenotypes. GNB3-T/+ and wild-type animals have similar activity levels and heat production; however, GNB3-T/+ mice exhibit dysregulation of acute thermogenesis. Finally, Ucp1 expression is significantly lower in white adipose tissue (WAT) in GNB3-T/+ mice, suggestive of WAT remodeling that could lead to impaired cellular thermogenesis. Taken together, our study provides the first functional link between GNB3 and obesity, and presents insight into novel pathways that could be applied to combat obesity and type 2 diabetes.
C1 [Ozdemir, Alev Cagla; Wynn, Grace M.; Rudd, M. Katharine] Emory Univ, Sch Med, Dept Human Genet, Atlanta, GA 30322 USA.
   [Vester, Aimee] Emory Univ, Dept Environm Hlth Sci, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA.
   [Weitzmann, M. Neale] Emory Univ, Sch Med, Div Endocrinol Metab & Lipids, Atlanta, GA USA.
   [Weitzmann, M. Neale; Srinivasan, Shanthi] Atlanta VA Med Ctr, Decatur, GA USA.
   [Neigh, Gretchen N.] Emory Univ, Sch Med, Dept Physiol, Atlanta, GA 30322 USA.
   [Neigh, Gretchen N.] Virginia Commonwealth Univ, Dept Anat & Neurobiol, Richmond, VA USA.
   [Srinivasan, Shanthi] Emory Univ, Sch Med, Div Digest Dis, Atlanta, GA USA.
   [Rudd, M. Katharine] Lab Corp Amer Holdings, Ctr Mol Biol & Pathol, Res Triangle Pk, NC 27709 USA.
C3 Emory University; Emory University; Rollins School Public Health; Emory
   University; US Department of Veterans Affairs; Veterans Health
   Administration (VHA); Atlanta VA Health Care System; Atlanta VA Medical
   Center; Emory University; Virginia Commonwealth University; Emory
   University
RP Rudd, MK (corresponding author), Emory Univ, Sch Med, Dept Human Genet, Atlanta, GA 30322 USA.; Rudd, MK (corresponding author), Lab Corp Amer Holdings, Ctr Mol Biol & Pathol, Res Triangle Pk, NC 27709 USA.
EM ruddm2@labcorp.com
RI Neigh, Gretchen/AAW-5691-2020; Srinivasan, Shanthi/A-6133-2013
FU Emory Discovery Fund; Emory University School of Medicine; Department of
   Human Genetics at Emory University; Emory Integrated Core Facilities
FX This work received support from the Emory Discovery Fund, an internal
   grant from the Department of Human Genetics at Emory University. Some
   experiments were conducted with the Emory Integrated Genomics Core
   (EIGC), which is subsidized by the Emory University School of Medicine
   and is one of the Emory Integrated Core Facilities.
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NR 51
TC 11
Z9 14
U1 0
U2 2
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD DEC 5
PY 2017
VL 12
IS 12
AR e0188763
DI 10.1371/journal.pone.0188763
PG 18
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA FO8CU
UT WOS:000417110700022
PM 29206867
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Bazmi, S
   Sepehrinia, M
   Pourmontaseri, H
   Bazyar, H
   Vahid, F
   Farjam, M
   Dehghan, A
   Hebert, JR
   Homayounfar, R
   Shakouri, N
AF Bazmi, Sina
   Sepehrinia, Matin
   Pourmontaseri, Hossein
   Bazyar, Hadi
   Vahid, Farhad
   Farjam, Mojtaba
   Dehghan, Azizallah
   Hebert, James R.
   Homayounfar, Reza
   Shakouri, Negin
TI Androgenic alopecia is associated with higher dietary inflammatory index
   and lower antioxidant index scores
SO FRONTIERS IN NUTRITION
LA English
DT Article
DE antioxidants; diet; pattern baldness; hair loss; metabolic syndrome;
   inflammation
ID METABOLIC SYNDROME; DISEASE; ONSET; RISK
AB Background Androgenic alopecia (AGA), the most prevalent hair loss type, causes major psychological distress and reduced quality of life. A definite and safe cure/prevention for this condition is still lacking. The role of oxidative stress and inflammation in AGA pathogenesis prompted us to investigate the association between dietary antioxidant index (DAI) and energy-adjusted dietary inflammatory index (E-DII) with AGA.Methods The investigation was designed based on data from 10,138 participants from the Fasa Adult Cohort Study (FACS). DAI and energy-adjusted DII (E-DII) were calculated utilizing a validated 125-item food frequency questionnaire (FFQ). A physician diagnosed AGA. Logistic regression models were utilized to evaluate the association of DAI and E-DII with AGA.Results After exclusion, 9,647 participants (44.0% men, mean age: 48.6 +/- 9.5 years) consisting of 7,348 participants with AGA entered the analyses. Higher DAI was associated with 10% lower AGA odds, while higher E-DII showed 4% higher AGA odds after adjusting for various confounding variables. However, significant associations were found only among women, and adjusting for metabolic syndrome (MetS) made the E-DII-AGA association insignificant.Conclusion Antioxidant-rich diets protect against AGA, while pro-inflammatory diets increase the risk, likely through developing MetS. Patient nutrition is frequently overlooked in clinical practice, yet it plays a crucial role, especially for women genetically predisposed to androgenetic alopecia. Dietary changes, such as reducing pro-inflammatory foods (like trans and saturated fats) and increasing anti-inflammatory options (fruits and vegetables), can help prevent hair loss and mitigate its psychological impacts, ultimately lowering future treatment costs.
C1 [Bazmi, Sina; Sepehrinia, Matin; Pourmontaseri, Hossein] Fasa Univ Med Sci, Student Res Comm, Fasa, Iran.
   [Sepehrinia, Matin; Farjam, Mojtaba; Dehghan, Azizallah; Shakouri, Negin] Fasa Univ Med Sci, Noncommunicable Dis Res Ctr, Fasa, Iran.
   [Bazyar, Hadi] Sirjan Sch Med Sci, Dept Publ Hlth, Sirjan, Iran.
   [Vahid, Farhad] Luxembourg Inst Hlth, Dept Precis Hlth, Nutr & Hlth Res Grp, Strassen, Luxembourg.
   [Hebert, James R.] Univ South Carolina, Arnold Sch Publ Hlth, Dept Epidemiol & Biostat, Columbia, SC USA.
   [Hebert, James R.] Univ South Carolina, Statewide Canc Prevent & Control Program, Columbia, SC USA.
   [Homayounfar, Reza] Shahid Beheshti Univ Med Sci, Fac Nutr Sci & Food Technol, Natl Nutr & Food Technol Res Inst, WHO Collaborating Ctr, Tehran, Iran.
C3 Luxembourg Institute of Health; University of South Carolina System;
   University of South Carolina Columbia; University of South Carolina
   System; University of South Carolina Columbia; World Health
   Organization; Shahid Beheshti University Medical Sciences
RP Shakouri, N (corresponding author), Fasa Univ Med Sci, Noncommunicable Dis Res Ctr, Fasa, Iran.; Homayounfar, R (corresponding author), Shahid Beheshti Univ Med Sci, Fac Nutr Sci & Food Technol, Natl Nutr & Food Technol Res Inst, WHO Collaborating Ctr, Tehran, Iran.
EM shakouri.negin92@gmail.com; r_homayounfar@yahoo.com
RI Vahid, Farhad/L-7547-2018; Dehghan, Azizallah/ABG-3704-2020; bazyar,
   hadi/AFG-3161-2022; Farjam, Mojtaba/O-3475-2017; Sepehrinia,
   Matin/KQU-1834-2024; Homayounfar, Reza/L-8813-2017; Shakouri,
   Negin/KMX-9685-2024; Hebert, James/IUO-5628-2023
OI Dehghan, Azizallah/0000-0002-7345-0796
FX The author(s) declare that no financial support was received for the
   research, authorship, and/or publication of this article.
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NR 49
TC 4
Z9 4
U1 4
U2 4
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD AUG 15
PY 2024
VL 11
AR 1433962
DI 10.3389/fnut.2024.1433962
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA E4I8F
UT WOS:001302665000001
PM 39211830
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Nakama, RP
   dos Santos, LF
   Berto-Pereira, L
   de Rossi, LS
   Malvezi, AD
   Lovo-Martins, MI
   Cardoso, APC
   de Freitas, AMD
   Martins-Pinge, MC
   Pinge, P
AF Nakama, Raquel Pires
   dos Santos, Lucas Felipe
   Berto-Pereira, Leonardo
   de Rossi, Lucas Sobral
   Malvezi, Aparecida Donizette
   Lovo-Martins, Maria Isabel
   Cardoso, Ana Paula Canizares
   de Freitas, Andressa Mendes Dionisio
   Martins-Pinge, Marli Cardoso
   Pinge-Filho, Phileno
TI Metabolic syndrome induces benefits in mice experiencing severe sepsis,
   comparable to the effects of low-dose aspirin pretreatment in septic
   mice lacking metabolic syndrome
SO INTERNATIONAL IMMUNOPHARMACOLOGY
LA English
DT Article
DE Aspirin; Inflammation; Sepsis; Obesity; Nitric oxide; Cytokines
ID OXIDATIVE STRESS; NITRIC-OXIDE; OBESITY; HYPOGLYCEMIA; HYPERTENSION;
   ASSOCIATION; PREVENTION; APOPTOSIS; FEMALE; SHOCK
AB Background: Sepsis is a complex condition characterized by systemic host inflammation caused by an infection. Experimental and observational studies indicate that obesity, one of the components of metabolic syndrome (MetS), or aspirin (ASA) treatment could be associated with sepsis survival. However, the effects of ASA on septic mice with MetS-induced conditions have not been explored. Methods: Swiss mice were administered monosodium glutamate (MSG) (4 mg/kg) during their first 5 days of life for MetS induction, while the control mice received an equimolar saline solution. MetS was validated in male mice on their 60th day of life. ASA treatment was administered for 15 days prior to sepsis (40 mg/kg). On the 75th day, sepsis was induced in MetS and control mice through cecal ligation and puncture (CLP). The effects of ASA on septic mice with MSG-induced MetS were assessed by determining survival rates, quantification of nitric oxide (NO), and cytokine levels in the plasma, while correlating these data with hematological, blood glucose and cardiovascular parameters. Results: MetS was validated by Lee-Index ( root body weight/naso-anal length x1000), hypertension, and hyper3 glycemia in animals receiving MSG as neonates. In control animals, severe sepsis promoted hypoglycemia, which was associated with mortality, as well as increased plasma NO levels, hypotension, hematological alterations, and elevation of proinflammatory cytokines. In contrast, MetS and pre-treatment with ASA were able to prevent sepsis-related alterations. Conclusions: MetS and ASA pre-treatment provided protection against severe sepsis. However, ASA was ineffective in mice with MetS undergoing severe sepsis.
C1 [Nakama, Raquel Pires; de Rossi, Lucas Sobral; Malvezi, Aparecida Donizette; Lovo-Martins, Maria Isabel; Cardoso, Ana Paula Canizares; Martins-Pinge, Marli Cardoso; Pinge-Filho, Phileno] Univ Estadual Londrina, Ctr Biol Sci, Dept Immunol Parasitol & Gen Pathol, Lab Expt Immunopathol, Londrina, PR, Brazil.
   [dos Santos, Lucas Felipe; Pinge-Filho, Phileno] Univ Estadual Londrina, Ctr Biol Sci, Dept Microbiol, Lab Microorganism Mol Biol, Londrina, PR, Brazil.
   [de Freitas, Andressa Mendes Dionisio] Univ Estadual Londrina, Ctr Biol Sci, Dept Physiol Sci, Lab Pharmacol Inflammat, Londrina, PR, Brazil.
   [Berto-Pereira, Leonardo; Martins-Pinge, Marli Cardoso] Univ Estadual Londrina, Ctr Biol Sci, Dept Physiol Sci, Lab Cardiovasc Physiol & Physiopathol, Londrina, PR, Brazil.
C3 Universidade Estadual de Londrina; Universidade Estadual de Londrina;
   Universidade Estadual de Londrina; Universidade Estadual de Londrina
RP Pinge, P (corresponding author), Univ Estadual Londrina, Ctr Biol Sci, Dept Immunol Parasitol & Gen Pathol, Lab Expt Immunopathol, Londrina, PR, Brazil.; Pinge, P (corresponding author), Univ Estadual Londrina, Ctr Biol Sci, Dept Microbiol, Lab Microorganism Mol Biol, Londrina, PR, Brazil.
EM pingefilho@uel.br
RI Pinge-Filho, Phileno/G-2844-2012; Pinge, Marli/C-4417-2014; Cardoso, Ana
   Paula/ITV-0081-2023; Freitas, Andressa/B-7264-2012
OI Freitas, Andressa/0000-0001-8453-7742
FU CAPES (Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior);
   CNPq (Conselho Nacional de Desenvolvimento Cientifico e Tecnologico)
   [306187/2022-1, 304114/2022-7]; Conselho Nacional de Desenvolvimento
   Cientifico e Tecnologico [404420/2023-0]; Fundacao Araucaria
   [376/2022/09/2021]; Secretaria de Estadoda Ciencia, Tecnologia, e Ensino
   Superiordo Parana [4560.19.571.06.6153]
FX The authors are grateful for the support provided by CAPES (Coordenacao
   de Aperfeicoamento de Pessoal de Nivel Superior) for the fellowships
   granted to RPN, LFS, LBP and LSR, as well as CNPq (Conselho Nacional de
   Desenvolvimento Cientifico e Tecnologico) for the research fellowships
   awarded to MCMP (process number 306187/2022-1) and PPF (process number
   304114/2022-7). This work was supported by Conselho Nacional de
   Desenvolvimento Cientifico e Tecnologico (grant number 404420/2023-0),
   Fundacao Araucaria (grant number 376/2022/09/2021) and Secretaria de
   Estadoda Ciencia, Tecnologia, e Ensino Superiordo Parana (grant number
   4560.19.571.06.6153). We thank Guilherme Bartolomeu Goncalves, MSc, from
   the Laboratory of Molecular Biology of Microorganisms, State University
   of Londrina, for proof reading this manuscript for grammatical accuracy.
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NR 56
TC 3
Z9 3
U1 0
U2 0
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1567-5769
EI 1878-1705
J9 INT IMMUNOPHARMACOL
JI Int. Immunopharmacol.
PD SEP 30
PY 2024
VL 139
AR 112694
DI 10.1016/j.intimp.2024.112694
EA JUL 2024
PG 11
WC Immunology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Pharmacology & Pharmacy
GA ZF5T3
UT WOS:001273901000001
PM 39024746
DA 2025-06-11
ER

PT J
AU Zhang, HJ
   Sun, T
   Cheng, YT
   Zhang, J
   Zhang, HX
   Krittanawong, C
   El-Am, E
   Abou Karam, R
   Wang, S
   Wang, Q
   Ma, N
AF Zhang, Hongju
   Sun, Tao
   Cheng, Yutong
   Zhang, Jing
   Zhang, HaiXia
   Krittanawong, Chayakrit
   El-Am, Edward
   Abou Karam, Roukoz
   Wang, Su
   Wang, Qian
   Ma, Ning
TI Impact of metabolic syndrome and systemic inflammation on endothelial
   function in postmenopausal women
SO TURK KARDIYOLOJI DERNEGI ARSIVI-ARCHIVES OF THE TURKISH SOCIETY OF
   CARDIOLOGY
LA English
DT Article
DE Postmenopausal; metabolic syndrome; systemic inflammation; endothelial
   function
ID CARDIOVASCULAR RISK; DYSFUNCTION; STRESS
AB Objective: Data on the impact of metabolic syndrome (MetS) and systemic inflammation on endothelial function remains scarce. In this study, we aimed to investigate the combined effects of MetS and systemic inflammation on endothelial function in postmenopausal women.
   Methods: We identified 423 postmenopausal women from February 2019 through July 2020. MetS was diagnosed according to the International Diabetes Federation (IDF) criteria, and high sensitivity C-reaction protein (hs-CRP) was measured to assess the degree of underlying inflammation. The measurement of endothelial function was using digital arterial tonometry by assessing reactive hyperemia-induced vasodilation in one arm and adjusting for changes in the contralateral arm (reactive hyperemia index, RHI).
   Results: There were 156 patients with MetS and 267 without MetS. Compared to the group without MetS, patients with MetS had significantly lower natural logarithmic RHI (0.66 +/- 0.29 versus 0.91 +/- 0.31; p<0.001), but higher levels of hs-CRP (0.98 [0.31, 3.54] versus 0.53 [0.20, 2.14]; p<0.001). In sequential multivariable analysis, the presence of hs-CRP (.R2=0.047, p=0.004) had a significant and independent influence on natural logarithmic RHI. Furthermore, the interaction of hs-CRP*MetS was synergistically associated with endothelial dysfunction even in the fully adjusted model (beta=-0.107, 95% CI [-0.161 similar to-0.053], p=0.009).
   Conclusion: MetS and systemic inflammation are synergistically associated with endothelial dysfunction in postmenopausal women. Postmenopausal women with both these conditions appear to be at a significantly higher risk for adverse cardiovascular events.
C1 [Zhang, Hongju; Ma, Ning] Capital Med Univ, Beijing Childrens Hosp, Natl Ctr Childrens Hlth, Dept Echocardiog, Beijing, Peoples R China.
   [Sun, Tao; Cheng, Yutong; Wang, Su; Wang, Qian] Capital Med Univ, Beijing Anzhen Hosp, Div Cardiol, Beijing, Peoples R China.
   [Zhang, Jing; Zhang, HaiXia] Beijng Childrens Hosp, Shunyi Maternal & Childrens Hosp, Dept Ultrasound, Beijing, Peoples R China.
   [Krittanawong, Chayakrit] Baylor Coll Med, Sect Cardiol, Houston, TX 77030 USA.
   [El-Am, Edward] Indiana Univ Sch Med, Dept Med, Indianapolis, IN 46202 USA.
   [Abou Karam, Roukoz] Harvard Med Sch, Beth Israel Deaconess Med Ctr, Cardiovasc Div, Boston, MA 02115 USA.
C3 Capital Medical University; Capital Medical University; Baylor College
   of Medicine; Indiana University System; Indiana University Bloomington;
   Harvard University; Harvard University Medical Affiliates; Beth Israel
   Deaconess Medical Center; Harvard Medical School
RP Ma, N (corresponding author), Capital Med Univ, Beijing Childrens Hosp, Natl Ctr Childrens Hlth, Dept Echocardiog, Beijing, Peoples R China.
EM maning_echo@163.com
RI Sun, Tao/HKO-1723-2023; Wang, Yong-Qiang/AAG-9444-2020; Abou-Karam,
   Roukoz/NFS-2432-2025
FU Natural Science Foundation of Beijing Municipality [7192062, 7202046]
FX This work was supported by Natural Science Foundation of Beijing
   Municipality; under Grant number 7192062 and 7202046.
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NR 31
TC 2
Z9 2
U1 1
U2 4
PU AVES
PI SISLI
PA BUYUKDERE CAD 105-9, MECIDIYEKOY, SISLI, ISTANBUL 34394, TURKEY
SN 1016-5169
J9 TURK KARDIYOL DERN A
JI Turk Kardiyol. Dern. Ars.
PD JAN
PY 2022
VL 50
IS 1
BP 58
EP 66
DI 10.5543/tkda.2022.47443
PG 9
WC Cardiac & Cardiovascular Systems
WE Emerging Sources Citation Index (ESCI)
SC Cardiovascular System & Cardiology
GA YE7XK
UT WOS:000741333800009
PM 35197234
OA Bronze
DA 2025-06-11
ER

PT J
AU Inoue, T
   Yoshida, K
   Sasaki, E
   Aizawa, K
   Kamioka, H
AF Inoue, Takuro
   Yoshida, Kazutaka
   Sasaki, Erika
   Aizawa, Koichi
   Kamioka, Hiroharu
TI Effects of lycopene intake on HDL-cholesterol and triglyceride levels: A
   systematic review with meta-analysis
SO JOURNAL OF FOOD SCIENCE
LA English
DT Review
ID DENSITY-LIPOPROTEIN CHOLESTEROL; CARDIOVASCULAR-DISEASE RISK; OXIDATIVE
   STRESS MARKERS; METABOLIC SYNDROME; TOMATO-JUICE; CAROTENOID
   CONCENTRATIONS; DIETARY SUPPLEMENTATION; MODERATELY OVERWEIGHT; LOWER
   PREVALENCE; PLASMA LYCOPENE
AB Lycopene is a lipophilic unsaturated carotenoid and has a very strong singlet oxygen-quenching ability. Increased serum or plasma lycopene levels have been reported to be associated with a lower risk of metabolic syndrome. We aimed to investigate the effects of lycopene intake on blood HDL-cholesterol (HCL-c) and triglyceride (TG) levels, which are metabolic syndrome biomarkers, by systematic review and meta-analyses of human interventional trials. We searched 15 databases and included studies that assessed the effects of oral lycopene intake on blood HDL-c and TG levels of participants >= 18 years of age. Three reviewers independently selected applicable studies, then assessed study qualities. Data were pooled as standardized mean difference (SMD) and analyzed by random-effects model. Heterogeneity was assessed by I-2 statistics. Meta-analysis including 12 trial arms (n = 781) revealed a significantly increased HDL-c level in the lycopene group compared with that in the control group (SMD = 0.33 [95% CI: 0.12, 0.54], p = 0.002) and moderate heterogeneity (I-2 = 45%). Most subgroup meta-analyses (restricted to study design, test food type, intake period, and participants' characteristics) showed similar results for HDL-c level. On the other hand, meta-analysis including 11 studies (n = 854) revealed no significant difference in TG level between the lycopene and control groups. Most studies which met eligibility criteria had moderate risk of bias. Funnel plots for HDL-c and TG suggested an absence of publication bias. In conclusion, this systematic review and meta-analyses suggested that lycopene intake significantly improved blood HDL-c levels but not TG levels.
C1 [Inoue, Takuro; Yoshida, Kazutaka; Sasaki, Erika; Aizawa, Koichi] KAGOME CO LTD, Innovat Div, Nat & Wellness Res Dept, 17 Nishitomiyama, Nasushiobara, Tochigi 3292762, Japan.
   [Inoue, Takuro; Kamioka, Hiroharu] Tokyo Univ Agr, Dept Ecol Symbiot Sci, Setagaya Ku, Tokyo, Japan.
C3 Kagome Co., Ltd.; Tokyo University of Agriculture
RP Inoue, T (corresponding author), KAGOME CO LTD, Innovat Div, Nat & Wellness Res Dept, 17 Nishitomiyama, Nasushiobara, Tochigi 3292762, Japan.
EM Takuro_Inoue@kagome.co.jp
FU KAGOME CO., LTD.
FX This research was funded by KAGOME CO., LTD.
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NR 71
TC 13
Z9 13
U1 4
U2 19
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-1147
EI 1750-3841
J9 J FOOD SCI
JI J. Food Sci.
PD AUG
PY 2021
VL 86
IS 8
BP 3285
EP 3302
DI 10.1111/1750-3841.15833
EA JUL 2021
PG 18
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA TZ2MV
UT WOS:000673801200001
PM 34268742
OA Bronze
DA 2025-06-11
ER

PT J
AU Sabbah, NA
   Rezk, NA
   Saad, MSS
AF Sabbah, Norhan Abdalla
   Rezk, Noha A.
   Saad, Mohamed S. S.
TI Relationship Between Heat Shock Protein Expression and Obesity With and
   Without Metabolic Syndrome
SO GENETIC TESTING AND MOLECULAR BIOMARKERS
LA English
DT Article
DE HSP70; HSP27; obesity; metabolic syndrome; diabetes mellitus
ID INSULIN SENSITIVITY; HOMEOSTASIS; GENE; HEAT-SHOCK-PROTEIN-70;
   INFLAMMATION; ASSOCIATION; CHOLESTEROL; RESISTANCE; KINASE
AB Background: Obesity is considered a chronic inflammatory disease in which the physiological mechanism responsible for reducing inflammation is weakened, prompting low-grade inflammation throughout the body. One of the key stress response systems that are dysregulated in obesity is the heat shock response, which is a critical defense mechanism that is activated in stressful conditions. Obesity is primary to metabolic syndrome (MetS) as it appears to lead to the increase in other MetS risk factors. Aim of the Study: We aimed to investigate the different expression levels of intracellular heat shock protein (iHSP) 70 and iHSP27 in obese patients with and without MetS and compare these levels to those of a lean control group. Patients and Methods: One hundred ten lean subjects were compared with 44 obese subjects without MetS and 56 obese subjects with MetS. HSP70 and HSP27 mRNA expression levels were measured by quantitative real-time polymerase chain reaction. Results: iHSP70 mRNA expression was significantly higher in obese subjects without MetS than in lean subjects (p = 0.04), whereas iHSP70 mRNA expression was significantly lower in obese subjects with MetS than in those without MetS (p = 0.02) as well as in those in the lean group (p = 0.03). iHSP27 mRNA expression was significantly lower in obese subjects with MetS than in those without MetS and in lean subjects (p = 0.037 and 0.031, respectively). Conclusion: We conclude that the intracellular expression levels of HSP70 and HSP27 may play an important role in the pathogenesis of MetS.
C1 [Sabbah, Norhan Abdalla; Rezk, Noha A.] Zagazig Univ, Fac Med, Dept Med Biochem, Zagazig 44512, Egypt.
   [Saad, Mohamed S. S.] Zagazig Univ, Fac Med, Dept Internal Med, Zagazig, Egypt.
C3 Egyptian Knowledge Bank (EKB); Zagazig University; Egyptian Knowledge
   Bank (EKB); Zagazig University
RP Sabbah, NA (corresponding author), Zagazig Univ, Fac Med, Dept Med Biochem, Zagazig 44512, Egypt.
EM mazenmahmoud17@yahoo.co.uk
RI Sabbah, Norhan/AAG-1489-2019
OI Sabbah, Norhan/0000-0003-2281-0621; rezk, noha/0000-0002-5199-0134
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NR 45
TC 9
Z9 9
U1 0
U2 8
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1945-0265
EI 1945-0257
J9 GENET TEST MOL BIOMA
JI Genet. Test. Mol. Biomark.
PD OCT 1
PY 2019
VL 23
IS 10
BP 737
EP 743
DI 10.1089/gtmb.2019.0062
EA SEP 2019
PG 7
WC Biochemistry & Molecular Biology; Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Genetics & Heredity
GA JE4PU
UT WOS:000486500900001
PM 31517511
DA 2025-06-11
ER

PT J
AU Cho, MR
   Park, JK
   Choi, WJ
   Cho, AR
   Lee, YJ
AF Cho, Mi-Ra
   Park, Jin-Kyung
   Choi, Won-Jun
   Cho, A-Ra
   Lee, Yong-Jae
TI Serum ferritin level is positively associated with insulin resistance
   and metabolic syndrome in postmenopausal women: A nationwide population
   based study
SO MATURITAS
LA English
DT Article
DE Ferritin; Inflammation; Insulin resistance; Metabolic syndrome;
   Menopause
ID CORONARY HEART-DISEASE; OXIDATIVE STRESS; IRON OVERLOAD; RISK-FACTORS;
   ESTROGEN; INFLAMMATION; RECEPTOR; MARKERS; ALPHA
AB Objective: Serum ferritin, a marker of iron metabolism, has recently emerged as a biomarker of chronic low-grade inflammation. After menopause, there is a remarkable increase in insulin resistance (IR) and metabolic syndrome (MetS), which is increasingly being viewed as an inflammatory disease. Thus, we examined the associations of serum ferritin with insulin resistance and MetS in postmenopausal women.
   Methods: A nationwide cross-sectional study was conducted to examine the relationship between serum ferritin and IR and MetS in 2734 postmenopausal women using data from the 2010-2012 Korean National Health and Nutrition Examination Survey. The odds ratios (ORs) and 95% confidence intervals (CIs) for insulin resistance (HOMA-IR >= 75th percentile, 3.04) and MetS were calculated using multiple logistic regression analyses across serum ferritin quartiles (Q1, <= 36.25; Q2, 36.56-56.56; Q3, 56.57-85.98; and Q4 >= 85.99 ng/ml).
   Results: The mean values of most cardiometabolic variables tended to increase proportionally with serum ferritin quartiles. The proportion of women with IR and MetS significantly increased in accordance with serum ferritin quartiles. Compared to individuals in the lowest quartile, the ORs (95% CIs) in the highest quartile were 2.06 (1.23-3.45) for IR and 1.92 (1.44-2.55) for MetS after adjusting for age, cigarette smoking, alcohol intake, and regular exercise.
   Conclusion: Serum ferritin levels were positively and independently associated with IR and MetS in postmenopausal women. These findings suggest that serum ferritin level in postmenopausal women may help to identify the presence of IR and MetS.
C1 [Cho, Mi-Ra; Park, Jin-Kyung; Choi, Won-Jun; Cho, A-Ra; Lee, Yong-Jae] Yonsei Univ, Coll Med, Dept Family Med, Seoul, South Korea.
C3 Yonsei University; Yonsei University Health System
RP Lee, YJ (corresponding author), Yonsei Univ, Coll Med, Gangnam Severance Hosp, Dept Family Med, 211 Eonju Ro, Seoul, South Korea.
EM ukyjhome@yuhs.ac
RI Lee, Yong Jae/GLR-4153-2022
OI Lee, Yong-Jae/0000-0002-6697-476X; CHO, A-RA/0000-0002-3645-2282; Choi,
   Won-Jun/0000-0002-8233-9272; Park, Jin-Kyung/0000-0002-3934-8632
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NR 26
TC 26
Z9 27
U1 0
U2 6
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0378-5122
EI 1873-4111
J9 MATURITAS
JI Maturitas
PD SEP
PY 2017
VL 103
BP 3
EP 7
DI 10.1016/j.maturitas.2017.06.004
PG 5
WC Geriatrics & Gerontology; Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology; Obstetrics & Gynecology
GA FD6UR
UT WOS:000407663900002
PM 28778329
DA 2025-06-11
ER

PT J
AU Alemany, M
AF Alemany, Maria
TI Regulation of adipose tissue energy availability through blood flow
   control in the metabolic syndrome
SO FREE RADICAL BIOLOGY AND MEDICINE
LA English
DT Review
DE White adipose tissue; Blood flow; Nitric oxide; Blood pressure;
   Metabolic syndrome; Obesity; Free radicals
ID NITRIC-OXIDE SYNTHASE; OBSTRUCTIVE SLEEP-APNEA; POLYUNSATURATED
   FATTY-ACIDS; DIET-INDUCED OBESITY; ENDOTHELIAL GROWTH-FACTOR; CIS-TRANS
   ISOMERIZATION; HUMAN SKELETAL-MUSCLE; INSULIN-RESISTANCE; OXIDATIVE
   STRESS; HEART-RATE
AB Maintenance of blood flow rate is a critical factor for tissue oxygen and substrate supply. The potentially large mass of adipose tissue deeply influences the body distribution of blood flow. This is due to increased peripheral resistance in obesity and the role of this tissue as the ultimate destination of unused excess of dietary energy. However, adipose tissue cannot grow indefinitely, and the tissue must defend itself against the avalanche of nutrients provoking inordinate growth and inflammation. In the obese, large adipose tissue masses show lower blood flow, limiting the access of excess circulating substrates. Blood flow restriction is achieved by vasoconstriction, despite increased production of nitric oxide, the vasodilatation effects of which are overridden by catecholamines (and probably also by angiotensin II and endothelin). Decreased blood flow reduces the availability of oxygen, provoking massive glycolysis (hyperglycemic conditions), which results in the production of lactate, exported to the liver for processing. However, this produces local acidosis, which elicits the rapid dissociation of oxyhemoglobin, freeing bursts of oxygen in localized zones of the tissue. The excess of oxygen (and of nitric oxide) induces the production of reactive oxygen species, which deeply affect the endothelial, blood, and adipose cells, inducing oxidative and nitrosative damage and eliciting an increased immune response, which translates into inflammation. The result of the defense mechanism for adipose tissue, localized vasoconstriction, may thus help develop a more generalized pathologic response within the metabolic syndrome parameters, extending its effects to the whole body. (C) 2012 Elsevier Inc. All rights reserved.
C1 [Alemany, Maria] Univ Barcelona, Fac Biol, Dept Nutr & Food Sci, E-08028 Barcelona, Spain.
C3 University of Barcelona
RP Alemany, M (corresponding author), Univ Barcelona, Fac Biol, Dept Nutr & Food Sci, E-08028 Barcelona, Spain.
EM malemany@ub.edu
RI Alemany, Maria/H-5224-2011
OI Alemany, Maria/0000-0002-9783-8293
FU Plan Nacional de Investigacion en Biomedicina of the Government of Spain
   [SAF2009-11739]
FX This work was supported by Grant SAF2009-11739 from the Plan Nacional de
   Investigacion en Biomedicina of the Government of Spain.
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NR 236
TC 26
Z9 28
U1 0
U2 18
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0891-5849
EI 1873-4596
J9 FREE RADICAL BIO MED
JI Free Radic. Biol. Med.
PD MAY 15
PY 2012
VL 52
IS 10
BP 2108
EP 2119
DI 10.1016/j.freeradbiomed.2012.03.003
PG 12
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 960HH
UT WOS:000305378100006
PM 22542444
DA 2025-06-11
ER

PT J
AU Li, YR
   Hong, ZX
AF Li, Yaru
   Hong, Zhongxin
TI Dose-Response Relationship of Serum Uric Acid and Incidence of Metabolic
   Syndrome and Components: A 4-Year Prospective Cohort Study
SO INTERNATIONAL JOURNAL OF GERONTOLOGY
LA English
DT Article
DE cardiovascular disease; metabolic syndrome; retrospective studies
ID RISK; HEALTH; HYPERURICEMIA; PREVALENCE; NUTRITION; OBESITY; STRESS;
   ADULTS; IMPACT
AB Background: The incidence of metabolic syndrome (MetS) dramatically increases among middle-aged and elderly populations in China, which increases the risk of cardiovascular disease events and mortality.Methods: This survey was based on the China Health and Retirement Longitudinal Study baseline data in 2011 and follow-up data in 2015. 4,602 participants without MetS at baseline were included in the final analysis. The diagnosis of MetS was based on the Chinese guidelines. A multivariable logistic re-gression model was used to examine the association of serum uric acid quartiles, or continuous serum uric acid with the risk of incident MetS. Restricted cubic spline regression models were used to explore the dose-response relationship between serum uric acid levels and MetS incidence.Results: Serum uric acid quartiles were associated with an increased risk of MetS incidence (p for trend = 0.03), and the adjusted RRs (95% CI) were 1.17 (0.77, 1.75), 1.51 (1.01, 2.24) and 1.54 (1.01, 2.33) in quartiles 2-4, respectively. In particular, the association was more evident among women. The multi -variable-adjusted RR for 1 mg/dL in serum uric acid level was 1.17 (95% CI: 1.03, 1.34) for MetS incidence. In addition, the restricted cubic splines showed that higher serum uric acid levels were dose- response associated with increased MetS incidence risk (p for linear trend < 0.001).Conclusions: Our results suggested that higher serum uric acid levels were independently associated with a dose-response increased risk of MetS incidence. Copyright (c) 2023, Taiwan Society of Geriatric Emergency & Critical Care Medicine.
C1 [Li, Yaru; Hong, Zhongxin] Capital Med Univ, Beijing Friendship Hosp, Dept Nutr, 95 Yongan St, Beijing 100050, Peoples R China.
C3 Capital Medical University
RP Hong, ZX (corresponding author), Capital Med Univ, Beijing Friendship Hosp, Dept Nutr, 95 Yongan St, Beijing 100050, Peoples R China.
EM hongzhongxin@vip.sina.com
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NR 29
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Z9 0
U1 2
U2 5
PU TAIWAN SOC GERIATRIC EMERGENCY & CRITICAL CARE MEDICINE-TSGECM
PI TAIPEI
PA 12F-14, NO 42, SEC 1, MINSHENG E RD, ZHONGSHAN DIST, TAIPEI, 104, TAIWAN
SN 1873-9598
EI 1873-958X
J9 INT J GERONTOL
JI Int. J. Gerontol.
PD OCT
PY 2023
VL 17
IS 4
BP 263
EP 268
DI 10.6890/IJGE.202310_17(4).0010
PG 6
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA W5EY1
UT WOS:001091868400011
DA 2025-06-11
ER

PT J
AU Zhou, X
   Fouda, S
   Zeng, XY
   Li, DL
   Zhang, K
   Xu, J
   Ye, JM
AF Zhou, Xiu
   Fouda, Sherouk
   Zeng, Xiao-Yi
   Li, Dongli
   Zhang, Kun
   Xu, Jun
   Ye, Ji-Ming
TI Characterization of the Therapeutic Profile of Albiflorin for the
   Metabolic Syndrome
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Article
DE albiflorin; metabolic syndrome; type 2 diabetes; non-alcoholic
   steatohepatitis; energy expenditure; physical activity
ID ACTIVATED PROTEIN-KINASE; ADENOSINE A(1) RECEPTOR; INDUCED
   INSULIN-RESISTANCE; FATTY LIVER-DISEASE; GLUCOSE-UPTAKE;
   DIETARY-CHOLESTEROL; PAEONIFLORIN; MUSCLE; RADIX; MICE
AB Albiflorin (AF) is a small molecule (MW 481) isolated from Paeoniae radix, a plant used as a remedy for various conditions with pathogenesis shared by metabolic diseases. Reported here is our characterization of its therapeutic profiles in three mouse models with distinctive pathological features of metabolic syndrome (MetS). Our results firstly showed that AF alleviated high fat (HF) induced obesity and associated glucose intolerance, suggesting its therapeutic efficacy for MetS. In the type 2 diabetes (T2D) model induced by a combination of HF and low doses of streptozotocin, AF lowered hyperglycaemia and improved insulin- stimulated glucose disposal. In the non-alcoholic steatohepatitis-like model resulting from a HF and high cholesterol (HF-HC) diet, AF reversed the increased liver triglyceride and cholesterol, plasma aspartate aminotransferase, and liver TNFa mRNA levels. Consistent with its effect in promoting glucose disposal in HF-fed mice, AF stimulated glucose uptake and GLUT4 translocation to the plasma membrane in L6 myotubes. However, these effects were unlikely to be associated with activation of insulin, AMPK, ER, or cellular stress signalling cascades. Further studies revealed that AF increased the whole-body energy expenditure and physical activity. Taken together, our findings indicate that AF exerts a therapeutic potential for MetS and related diseases possibly by promoting physical activity associated whole-body energy expenditure and glucose uptake in muscle. These effects are possibly mediated by a new mechanism distinct from other therapeutics derived from Chinese medicine.
C1 [Zhou, Xiu; Li, Dongli; Zhang, Kun; Xu, Jun; Ye, Ji-Ming] Wuyi Univ, Sch Biotechnol & Hlth Sci, Jiangmen, Peoples R China.
   [Zhou, Xiu; Fouda, Sherouk; Zeng, Xiao-Yi; Ye, Ji-Ming] RMIT Univ, Sch Hlth & Biomed Sci, Melbourne, Vic, Australia.
   [Zhou, Xiu; Zhang, Kun] Guangdong Univ Technol, Sch Biomed & Pharmaceut Sci, Guangzhou, Guangdong, Peoples R China.
C3 Wuyi University; Royal Melbourne Institute of Technology (RMIT);
   Guangdong University of Technology
RP Zhou, X; Ye, JM (corresponding author), Wuyi Univ, Sch Biotechnol & Hlth Sci, Jiangmen, Peoples R China.; Zhou, X; Ye, JM (corresponding author), RMIT Univ, Sch Hlth & Biomed Sci, Melbourne, Vic, Australia.; Zhou, X (corresponding author), Guangdong Univ Technol, Sch Biomed & Pharmaceut Sci, Guangzhou, Guangdong, Peoples R China.
EM zhou.xiu@hotmail.com; jiming.ye@rmit.edu.au
RI ZHOU, XIU/AAX-5312-2020; Zhang, Kun/S-5005-2019; Fouda,
   Sherouk/AAF-5823-2020
OI Fouda, Dr Sherouk/0000-0001-8227-4571
FU National Natural Science Foundation of China [535921]; Jiangmen Program
   for Innovative Research Team (China) [81870608];  [2018630100180019806]
FX This work was supported by NHMC Program Grant of Australia (535921),
   National Natural Science Foundation of China (81870608) and Jiangmen
   Program for Innovative Research Team (China) (2018630100180019806).
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NR 56
TC 16
Z9 17
U1 0
U2 15
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD OCT 11
PY 2019
VL 10
AR 1151
DI 10.3389/fphar.2019.01151
PG 13
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA JO4BV
UT WOS:000497525600001
PM 31680948
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Afrand, M
   Bashardoost, N
   Sheikhha, MH
   Afkhami-Ardekani, M
AF Afrand, Mohammadhosain
   Bashardoost, Nasrollah
   Sheikhha, Mohammad Hasan
   Afkhami-Ardekani, Mohammad
TI Association between Glutathione S-Transferase GSTM1-T1 and P1
   Polymorphisms with Metabolic Syndrome in Zoroastrians in Yazd, Iran
SO IRANIAN JOURNAL OF PUBLIC HEALTH
LA English
DT Article
DE Glutathione S-transferase; Genetic polymorphism; Metabolic syndrome;
   Ethnic group; Iran
ID OXIDATIVE STRESS; INSULIN-RESISTANCE; SUPERGENE FAMILY; GSTT1;
   CONTRIBUTES; OBESITY; CANCER; MEN
AB Background: The aim of this study was to assess the possible association between genetic polymorphisms of the glutathione S-transferase (GST) gene family and the risk of the development of metabolic syndrome (MS) in Zoroastrian females in Yazd, Iran.
   Methods: In this case-control study, GSTM1, T1, and P1 polymorphisms were genotyped in 51 randomly selected MS patients and 50 randomly selected healthy controls on February 2014 among Zoroastrian females whose ages ranged from 40 to 70 yr. DNA was extracted from peripheral blood. Data were analyzed with SPSS version 17.
   Results: We observed a significant association of GSTP1-I/V (Isoleucine/Valine) allele and GSTP1-V/V (Valine / Valine) allele with MS (P = 0.047 and P = 0.044, respectively). The combined analysis of the two genotypes, the present genotype of GSTT1, I/V and V/V alleles of GSTP1 genotype demonstrated a decrease in the risk of acquiring MS (OR = 0.246, P = 0.031). The null genotype of GSTM1, I/V, and V/V alleles of the GSTP1 genotype showed a lower risk in double combinations (OR = 0.15, P = 0.028 and OR = 0.13, P = 0.013, respectively). The combinations of the GSTM1 null genotypes and GSTT1 present genotypes and the GSTP1 I/V and V/V alleles together were associated with decreased risk of having MS in triple combinations (OR = 0.071, P = 0.039 and OR = 0.065, P = 0.022, respectively).
   Conclusion: GSTP1-I/V and V/V alleles, alone or in association with GSTM1 null and GSTT1 present genotypes, are related with decreased susceptibility to the development of MS in Zoroastrian females.
C1 [Afrand, Mohammadhosain] Islamic Azad Univ, Yazd Branch, Ali Ebne Abitaleb Fac Med, Med Sci Assoc, Yazd, Iran.
   [Bashardoost, Nasrollah] Islamic Azad Univ, Yazd Branch, Ali Ebne Abitaleb Fac Med, Dept Biostat & Epidemiol, Yazd, Iran.
   [Sheikhha, Mohammad Hasan] Shahid Sadoughi Univ Med Sci, Yazd Diabet Res Ctr, Dept Med Genet, Yazd, Iran.
   [Afkhami-Ardekani, Mohammad] Shahid Sadoughi Univ Med Sci, Yazd Diabet Res Ctr, Dept Endocrinol, Yazd, Iran.
C3 Islamic Azad University; Islamic Azad University; Shahid Sadoughi
   University of Medical Sciences; Shahid Sadoughi University of Medical
   Sciences
RP Afrand, M (corresponding author), Islamic Azad Univ, Yazd Branch, Ali Ebne Abitaleb Fac Med, Med Sci Assoc, Yazd, Iran.
EM Afrand@iauyazd.ac.ir
RI Afkhami-ardakani, Mohammad/AAP-9044-2021; Afrand,
   Mohammadhosain/ABD-7176-2020; Afrand, Mohammadhosain/G-2262-2014;
   Sheikhha, Mohammad Hasan/Q-7643-2017
OI Afrand, Mohammadhosain/0000-0003-3226-8119; Sheikhha, Mohammad
   Hasan/0000-0002-3734-8970
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NR 34
TC 9
Z9 10
U1 0
U2 1
PU IRANIAN SCIENTIFIC SOCIETY MEDICAL ENTOMOLOGY
PI TEHRAN
PA SCHOOL PUBLIC HEALTH & INST HEALTH RESEARCH, TEHRAN UNIV MEDICAL
   SCIENCES, P O BOX  6446-14155, TEHRAN, 00000, IRAN
SN 2251-6085
EI 2251-6093
J9 IRAN J PUBLIC HEALTH
JI Iran J. Public Health
PD MAY
PY 2015
VL 44
IS 5
BP 673
EP 682
PG 10
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA CJ9SU
UT WOS:000355843800009
PM 26284209
DA 2025-06-11
ER

PT J
AU Cox, CL
   Stanhope, KL
   Schwarz, JM
   Graham, JL
   Hatcher, B
   Griffen, SC
   Bremer, AA
   Berglund, L
   McGahan, JP
   Keim, NL
   Havel, PJ
AF Cox, Chad L.
   Stanhope, Kimber L.
   Schwarz, Jean Marc
   Graham, James L.
   Hatcher, Bonnie
   Griffen, Steven C.
   Bremer, Andrew A.
   Berglund, Lars
   McGahan, John P.
   Keim, Nancy L.
   Havel, Peter J.
TI Consumption of fructose- but not glucose-sweetened beverages for 10
   weeks increases circulating concentrations of uric acid, retinol binding
   protein-4, and gamma-glutamyl transferase activity in overweight/obese
   humans
SO NUTRITION & METABOLISM
LA English
DT Article
ID METABOLIC SYNDROME; INSULIN-RESISTANCE; VISCERAL ADIPOSITY; DIETARY
   FRUCTOSE; OXIDATIVE STRESS; LIVER; INFLAMMATION; OBESITY; LIPIDS;
   RETINOL-BINDING-PROTEIN-4
AB Background: Prospective studies in humans examining the effects of fructose consumption on biological markers associated with the development of metabolic syndrome are lacking. Therefore we investigated the relative effects of 10 wks of fructose or glucose consumption on plasma uric acid and RBP-4 concentrations, as well as liver enzyme (AST, ALT, and GGT) activities in men and women.
   Methods: As part of a parallel arm study, older (age 40-72), overweight and obese male and female subjects (BMI 25-35 kg/m(2)) consumed glucose- or fructose-sweetened beverages providing 25% of energy requirements for 10 wks. Fasting and 24-h blood collections were performed at baseline and following 10 wks of intervention and plasma concentrations of uric acid, RBP-4 and liver enzyme activities were measured.
   Results: Consumption of fructose, but not glucose, led to significant increases of 24-h uric acid profiles (P < 0.0001) and RBP-4 concentrations (P = 0.012), as well as plasma GGT activity (P = 0.04). Fasting plasma uric acid concentrations increased in both groups; however, the response was significantly greater in subjects consuming fructose (P = 0.002 for effect of sugar). Within the fructose group male subjects exhibited larger increases of RBP-4 levels than women (P = 0.024).
   Conclusions: These findings suggest that consumption of fructose at 25% of energy requirements for 10 wks, compared with isocaloric consumption of glucose, may contribute to the development of components of the metabolic syndrome by increasing circulating uric acid, GGT activity, suggesting alteration of hepatic function, and the production of RBP-4.
C1 [Stanhope, Kimber L.; Graham, James L.; Havel, Peter J.] Univ Calif Davis, Sch Vet Med, Dept Mol Biosci, Davis, CA 95616 USA.
   [Cox, Chad L.; Stanhope, Kimber L.; Graham, James L.; Hatcher, Bonnie; Keim, Nancy L.; Havel, Peter J.] Univ Calif Davis, Dept Nutr, Davis, CA 95616 USA.
   [Schwarz, Jean Marc] Touro Univ, Dept Basic Sci, Coll Osteopath Med, Vallejo, CA 94592 USA.
   [Griffen, Steven C.; Berglund, Lars] UCD Sch Med, Dept Internal Med, Sacramento, CA 95817 USA.
   [Bremer, Andrew A.] Vanderbilt Univ, Sch Med, Dept Pediat, Nashville, TN 37232 USA.
   [Keim, Nancy L.] USDA, Western Human Nutr Res Ctr, Davis, CA 95616 USA.
   [McGahan, John P.] UCD Med Ctr, Dept Radiol, Sacramento, CA 95817 USA.
C3 University of California System; University of California Davis;
   University of California System; University of California Davis; Touro
   University California; Vanderbilt University; United States Department
   of Agriculture (USDA)
RP Havel, PJ (corresponding author), Univ Calif Davis, Sch Vet Med, Dept Mol Biosci, 1 Shields Ave, Davis, CA 95616 USA.
EM pjhavel@ucdavis.edu
RI Havel, Peter/AFU-9329-2022
OI Berglund, Lars/0000-0001-6705-1791; Havel, Peter/0000-0003-3652-8301;
   Graham, James/0000-0001-6507-8149
FU NIH grant [RO1 HL-075675, HL-091333, AT-003545, DK-097307]; National
   Center for Research Resources (NCRR) [UL1 RR024146]; National Institutes
   of Health (NIH); NIH Roadmap for Medical Research; USDA-ARS [CRIS
   5306-51530-016-00D]
FX The authors thank Marinelle Nunez, Brandi Bair, Rebecca Stewart, Sara
   Wuehler, Barbara Gale, Artem Dyachenko and Patrick Lam for their
   excellent technical support and Nicole Mullen and the nursing staff at
   the CCRC for their dedicated nursing support. We also thank Janet
   Peerson for expert advice on the statistical analysis of the data. This
   research was supported with funding from NIH grant RO1 HL-075675. The
   project also received support from Grant Number UL1 RR024146 from the
   National Center for Research Resources (NCRR), a component of the
   National Institutes of Health (NIH), and NIH Roadmap for Medical
   Research. Dr. Havel's laboratory also receives support from NIH grants
   HL-091333, AT-003545, and DK-097307. Dr. Keim's research is supported by
   intramural USDA-ARS CRIS 5306-51530-016-00D.
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NR 46
TC 117
Z9 131
U1 1
U2 21
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1743-7075
J9 NUTR METAB
JI Nutr. Metab.
PD JUL 24
PY 2012
VL 9
AR 68
DI 10.1186/1743-7075-9-68
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 015TN
UT WOS:000309469200001
PM 22828276
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Elmorsy, EA
   Elashry, HA
   Alkhamiss, AS
   Alsaykhan, H
   Hamad, RS
   Abdel-Reheim, MA
   Alsoghair, M
   Alharbi, MS
   Gabr, AM
   Ellethy, AT
   Khodeir, MM
   Hassan, AM
   Elsisi, HA
   Farrag, AA
   Alsoqih, NS
   Sameh, A
   Saber, S
AF Elmorsy, Elsayed A.
   Elashry, Hala A.
   Alkhamiss, Abdullah S.
   Alsaykhan, Hamad
   Hamad, Rabab S.
   Abdel-Reheim, Mustafa Ahmed
   Alsoghair, Mansour
   Alharbi, Mariam S.
   Gabr, Attia M.
   Ellethy, Abousree T.
   Khodeir, Mostafa M.
   Hassan, Ageeb M.
   Elsisi, Hossam A.
   Farrag, Alshaimaa A.
   Alsoqih, Norah Suliman
   Sameh, Ahmed
   Saber, Sameh
TI E1231/NMN protects against experimental metabolic syndrome: the central
   role of SIRT1 in modulating AKT/Nrf2/NFκB signaling
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Article
DE E1231; EX527; SIRT1; metabolic syndrome; AKT/Nrf2/NF kappa B; insulin
   resistance
ID NF-KAPPA-B; INSULIN-RESISTANCE; INFLAMMATION; OXYGENASE; MODELS; PLASMA;
   LIVER; MICE
AB Metabolic syndrome (MetS) is a cluster of several disorders where many challenges hinder effective treatment. The downregulation of SIRT1 or inhibition of its activity is implicated in its pathophysiology. We hypothesized that the combined SIRT1 direct activator E1231 and the SIRT1 stabilizer nicotinamide mononucleotide (NMN) could offer a novel approach to mitigate the pathophysiological features of MetS. Our results revealed that E1231 alone or combined with NMN increased SIRT1 level and activity. This SIRT1 activation was accompanied by upregulation in the IRS-1 and activation of AKT. In parallel, the Nrf2 level and activity were increased while the NF kappa B activity and subsequent inflammatory cytokines were decreased. Additionally, SIRT1 activation was associated with improved insulin resistance, blood pressure, lipid profile, fasting blood glucose, glucose tolerance, and kidney and liver functions. Moreover, improved liver histology, decreased hepatic fibrosis markers, and increased survival rates were observed. These protective functions were counteracted when EX527, a SIRT1 inhibitor, was dually administered with E1231. Furthermore, correlation analysis revealed that SIRT1 was negatively correlated with NF kappa B, insulin resistance, and oxidative stress, while positive correlations were observed between SIRT1, p-AKT, and Nrf2 activity. Random Forest regression algorithm and partial dependence plots highlighted the significant roles of SIRT1, IRS-1, p-AKT, and NF kappa B in predicting MetS severity. These analyses underscore the strong interconnections between these signals. This reinforces the central role of SIRT1 in coordinating a multifaceted protective response against MetS. To conclude, SIRT1 alleviates MetS by modulating AKT/Nrf2/NF kappa B signaling and their interactions. Further research is necessary to validate these findings.
C1 [Elmorsy, Elsayed A.; Gabr, Attia M.; Elsisi, Hossam A.] Qassim Univ, Coll Pharm, Dept Pharmacol & Toxicol, Buraydah, Saudi Arabia.
   [Elmorsy, Elsayed A.; Elashry, Hala A.] Mansoura Univ, Fac Med, Dept Clin Pharmacol, Mansoura, Egypt.
   [Alkhamiss, Abdullah S.; Khodeir, Mostafa M.; Hassan, Ageeb M.] Qassim Univ, Coll Med, Dept Pathol, Buraydah, Saudi Arabia.
   [Alsaykhan, Hamad] Qassim Univ, Coll Med, Dept Anat & Histol, Buraydah, Saudi Arabia.
   [Hamad, Rabab S.] King Faisal Univ, Coll Sci, Biol Sci Dept, Al Hasa, Saudi Arabia.
   [Abdel-Reheim, Mustafa Ahmed] Shaqra Univ, Coll Pharm, Dept Pharmacol, Shaqra, Saudi Arabia.
   [Alsoghair, Mansour] Qassim Univ, Coll Med, Dept Family & Community Med, Buraydah, Saudi Arabia.
   [Alharbi, Mariam S.] Qassim Univ, Coll Med, Dept Med, Buraydah, Saudi Arabia.
   [Ellethy, Abousree T.] Qassim Univ, Coll Dent, Dept Basic Oral Sci & Dent Educ, Biochem Div, Buraydah, Saudi Arabia.
   [Khodeir, Mostafa M.] Cairo Univ, Fac Med, Dept Pathol, Cairo, Egypt.
   [Elsisi, Hossam A.] Zagazig Univ, Fac Med, Dept Clin Pharmacol, Zagazig, Egypt.
   [Farrag, Alshaimaa A.] Univ Bisha, Coll Med, Dept Anat, Bisha, Saudi Arabia.
   [Alsoqih, Norah Suliman] Qassim Univ, Coll Med, Dept Pediat, Buraydah, Saudi Arabia.
   [Sameh, Ahmed] Egypt Univ Informat, Fac Comp & Informat Sci, Cairo, Egypt.
   [Saber, Sameh] Delta Univ Sci & Technol, Fac Pharm, Dept Pharmacol, Gamasa, Egypt.
C3 Qassim University; Egyptian Knowledge Bank (EKB); Mansoura University;
   Qassim University; Qassim University; King Faisal University; Shaqra
   University; Qassim University; Qassim University; Qassim University;
   Egyptian Knowledge Bank (EKB); Cairo University; Egyptian Knowledge Bank
   (EKB); Zagazig University; University of Bisha; Qassim University; Delta
   University for Science & Technology
RP Elmorsy, EA (corresponding author), Qassim Univ, Coll Pharm, Dept Pharmacol & Toxicol, Buraydah, Saudi Arabia.; Elmorsy, EA (corresponding author), Mansoura Univ, Fac Med, Dept Clin Pharmacol, Mansoura, Egypt.; Hamad, RS (corresponding author), King Faisal Univ, Coll Sci, Biol Sci Dept, Al Hasa, Saudi Arabia.; Abdel-Reheim, MA (corresponding author), Shaqra Univ, Coll Pharm, Dept Pharmacol, Shaqra, Saudi Arabia.; Farrag, AA (corresponding author), Univ Bisha, Coll Med, Dept Anat, Bisha, Saudi Arabia.; Saber, S (corresponding author), Delta Univ Sci & Technol, Fac Pharm, Dept Pharmacol, Gamasa, Egypt.
EM a.almarsa@qu.edu.sa; m.ahmed@su.edu.sa; sameh.saber@deltauniv.edu.eg;
   rhamad@kfu.edu.sa; afarraj@ub.edu.sa
RI Sameh, A./ADT-8344-2022; Hamad, Rabab/H-9104-2016; saber,
   Sameh/AAE-8616-2020; Khodeir, Mostafa/JEO-9343-2023; ALKHAMISS,
   ABDULLAH/LUA-0493-2024; Elmorsy, Elsayed/KXR-1785-2024
OI Elmorsy, Elsayed A./0000-0001-6165-3847; Farrag, Alshaimaa A.
   M./0009-0007-0696-853X
FU International Collaboration Office at Delta University; Deanship of
   Scientific Research, Vice Presidency for Graduate Studies and Scientific
   Research, King Faisal University, Saudi Arabia [KFU250814]; Deanship of
   Graduate Studies and Scientific Research at Qassim University
   [QU-APC-2025]; Deanship of Graduate Studies and Scientific Research at
   University of Bisha; Deanship of Scientific Research at Shaqra
   University
FX The authors would like to express their gratitude to the International
   Collaboration Office at Delta University for Science and Technology for
   their valuable support and assistance. The Researchers would like to
   thank the Deanship of Graduate Studies and Scientific Research at Qassim
   University for financial support (QU-APC-2025). The authors are thankful
   to the Deanship of Graduate Studies and Scientific Research at
   University of Bisha for supporting this work through the Fast-Track
   Research Support Program. The authors would like to thank the Deanship
   of Scientific Research at Shaqra University for supporting this work.
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NR 51
TC 0
Z9 0
U1 0
U2 0
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD MAR 17
PY 2025
VL 16
AR 1558709
DI 10.3389/fphar.2025.1558709
PG 18
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 0SP0N
UT WOS:001455025500001
PM 40166461
OA gold
DA 2025-06-11
ER

PT J
AU Aljehani, AA
   Albadr, NA
   Nasrullah, MZ
   Neamatallah, T
   Eid, BG
   Abdel-Naim, AB
AF Aljehani, Abeer A.
   Albadr, Nawal A.
   Nasrullah, Mohammed Z.
   Neamatallah, Thikryat
   Eid, Basma G.
   Abdel-Naim, Ashraf B.
TI Icariin ameliorates metabolic syndrome-induced benign prostatic
   hyperplasia in rats
SO ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
LA English
DT Article
DE Icariin; Benign prostatic hyperplasia; Metabolic syndrome; Adenosine
   monophosphate (AMP)-activated protein kinase; High fructose-drinking
   water; High-salt diet
ID OXIDATIVE STRESS; CANCER CELLS; EXPRESSION; GROWTH; APOPTOSIS;
   ACTIVATION; PATHWAY
AB Metabolic syndrome (MetS) is an immense health issue that causes serious complications in aging males including BPH. Icariin (ICA) is a flavonol glycoside that exerts a plethora of pharmacological effects. The present investigation tested the potential of ICA to ameliorate benign prostatic hyperplasia (BPH) induced by MetS in rats. Animals were allocated to 5 groups in which the first and second groups were kept on water and regular food pellets. MetS was induced in the third, fourth, and fifth groups by keeping the animals on high fructose and salt diets for twelve consecutive weeks. These groups were given vehicle, ICA (25 mg/kg), and ICA (50 mg/kg), respectively. MetS was confirmed by an increase in rats' weight, accumulation of visceral fat, insulin resistance, and dyslipidemia. This was accompanied by manifestation of BPH including increased prostate weight, prostate index, and histopathological alterations. Treating the animals with both doses of ICA significantly ameliorated the increase in weight and index of the prostate as well as altered prostate histopathology. In addition, ICA significantly decreased cyclin D1 expression, upregulated Bax, and downregulated Bcl2 mRNA expression. ICA prevented lipid peroxidation, reduced glutathione depletion, and catalase exhaustion, which further lowered markers of prostate inflammation such as interleukin-6 and tumor necrosis factor-alpha. Moreover, ICA prevented the decrease in prostate content of phosphorylated 5 '-adenosine monophosphate (AMP)-activated protein kinase (pAMPK). In conclusion, ICA protects against MetS-induced BPH. This is due to its antiproliferative, proapoptotic, antioxidant, and anti-inflammatory activities as well as the activation of AMPK.
C1 [Aljehani, Abeer A.; Albadr, Nawal A.] King Saud Univ, Coll Food & Agr Sci, Dept Food Sci & Nutr, Riyadh, Saudi Arabia.
   [Nasrullah, Mohammed Z.; Neamatallah, Thikryat; Eid, Basma G.; Abdel-Naim, Ashraf B.] King Abdulaziz Univ, Fac Pharm, Dept Pharmacol & Toxicol, Jeddah, Saudi Arabia.
C3 King Saud University; King Abdulaziz University
RP Abdel-Naim, AB (corresponding author), King Abdulaziz Univ, Fac Pharm, Dept Pharmacol & Toxicol, Jeddah, Saudi Arabia.
EM aaabdulakahman1@kau.edu.sa
RI Aljehani, Abeer/NIS-8927-2025; Eid, Basma/F-3962-2018; Nasrullah,
   Mohammed/AAS-5040-2021; Neamatallah, Thikryat/L-7201-2016; Abdel-Naim,
   Ashraf/J-3199-2012
OI Nasrullah, Mohammed/0000-0002-4755-0742
FU Deanship of Scientific Research in King Saud University through the
   initiative of DSR Graduate Students Research Support (GSR)
FX The study was funded by the Deanship of Scientific Research in King Saud
   University through the initiative of DSR Graduate Students Research
   Support (GSR).
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NR 58
TC 12
Z9 13
U1 0
U2 38
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0944-1344
EI 1614-7499
J9 ENVIRON SCI POLLUT R
JI Environ. Sci. Pollut. Res.
PD MAR
PY 2022
VL 29
IS 14
BP 20370
EP 20378
DI 10.1007/s11356-021-17245-4
EA NOV 2021
PG 9
WC Environmental Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology
GA ZN4QS
UT WOS:000714334100001
PM 34734339
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Hermans, MP
   Lempereur, P
   Salembier, JP
   Maes, N
   Albert, A
   Jansen, O
   Pincemail, J
AF Hermans, Michel P.
   Lempereur, Philippe
   Salembier, Jean-Paul
   Maes, Nathalie
   Albert, Adelin
   Jansen, Olivia
   Pincemail, Joel
TI Supplementation Effect of a Combination of Olive (Olea europea
   L.) Leaf and Fruit Extracts in the Clinical Management of Hypertension
   and Metabolic Syndrome
SO ANTIOXIDANTS
LA English
DT Article
DE Olea europea L; olive extracts; oleuropein; hydroxytyrosol;
   hypertension; metabolic syndrome
ID BLOOD-PRESSURE; OXIDATIVE STRESS; ENDOTHELIAL FUNCTION; MEDITERRANEAN
   DIET; OIL CONSUMPTION; HYDROXYTYROSOL; RISK; INFLAMMATION; POLYPHENOLS;
   OLEUROPEIN
AB Background: The role of herbal products in the prevention of cardiovascular disease requires supporting evidence. This open pilot study assessed the effect of 2-month supplementation of a combination of olive leaf and fruit extracts (Tensiofytol(R), Tilman SA, Baillonville, Belgium) in the clinical management of hypertension and metabolic syndrome (MetS). Methods: A total of 663 (pre)-hypertensive patients were enrolled by general practitioners and supplemented for two months with Tensiofytol(R), two capsules per day (100 mg/d of oleuropein and 20 mg/d of hydroxytyrosol). Systolic and diastolic blood pressures (SBP/DBP) were measured before and after treatment. Markers of MetS, high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), fasting blood glucose (FG) and waist circumference (WC), were also examined. Results: Significant reductions (p < 0.0001) in SBP/DBP (13 +/- 10/7.1 +/- 6.6 mmHg) were observed and similarly in pre-diabetic and diabetic patients. Improvements in SBP/DPB were independent of age and gender but greater for elevated baseline SBP/DBP. Tensiofytol(R) supplementation also significantly improved markers of MetS, with a decrease of TG (11%), WC (1.4%) and FG (4.8%) and an increase of HDL-C (5.3%). Minor side effects were reported in 3.2% patients. Conclusions: This real-life, observational, non-controlled, non-randomized pilot study shows that supplementation of a combination of olive leaf and fruit extracts may be used efficiently and safely in reducing hypertension and MetS markers.
C1 [Hermans, Michel P.] UCLouvain, Inst Rech Expt & Clin, Serv Endocrinol & Nutr & Pole Endocrinol Diabete, B-1200 Brussels, Belgium.
   [Lempereur, Philippe] Ctr Hosp Bois Abbaye, Serv Cardiol, B-4100 Seraing, Belgium.
   [Salembier, Jean-Paul] CHU UCL Namur, Serv Cardiol, Site Sainte Elisabeth, B-5000 Namur, Belgium.
   [Maes, Nathalie; Albert, Adelin] Univ Hosp Liege, Biostat & Medicoecon Informat Dept, B-4000 Liege, Belgium.
   [Jansen, Olivia] Univ Liege, Ctr Interdisciplinaire Rech Medicament CIRM, Lab Pharmacognosie, B-4000 Liege, Belgium.
   [Pincemail, Joel] CHU, CREDEC, Dept Cardiovasc Surg, B-4000 Liege, Belgium.
   [Pincemail, Joel] CHU, Platform Nutr Antioxydante & Sante, B-4000 Liege, Belgium.
   [Pincemail, Joel] Univ Liege, B-4000 Liege, Belgium.
C3 Universite Catholique Louvain; University of Liege; University of Liege;
   University of Liege; University of Liege; University of Liege
RP Pincemail, J (corresponding author), CHU, CREDEC, Dept Cardiovasc Surg, B-4000 Liege, Belgium.; Pincemail, J (corresponding author), CHU, Platform Nutr Antioxydante & Sante, B-4000 Liege, Belgium.; Pincemail, J (corresponding author), Univ Liege, B-4000 Liege, Belgium.
EM michel.hermans@uclouvain.be; philippe.lempereur@skynet.be;
   jeanpaulsalembier@yahoo.fr; nmaes@chuliege.be; aalbert@uliege.be;
   ojansen@uliege.be; j.pincemail@chuliege.be
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NR 75
TC 26
Z9 26
U1 1
U2 10
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD SEP
PY 2020
VL 9
IS 9
AR 872
DI 10.3390/antiox9090872
PG 15
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA OG6ZK
UT WOS:000582029500001
PM 32942738
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Zhang, LH
   Zhu, XY
   Eirin, A
   Nargesi, AA
   Woollard, JR
   Santelli, A
   Sun, IO
   Textor, SC
   Lerman, LO
AF Zhang, Li-Hong
   Zhu, Xiang-Yang
   Eirin, Alfonso
   Nargesi, Arash Aghajani
   Woollard, John R.
   Santelli, Adrian
   Sun, In O.
   Textor, Stephen C.
   Lerman, Lilach O.
TI Early podocyte injury and elevated levels of urinary podocyte-derived
   extracellular vesicles in swine with metabolic syndrome: role of
   podocyte mitochondria
SO AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
LA English
DT Article
DE extracellular vesicles; metabolic syndrome; mitochondria; podocyte
ID KIDNEY-DISEASE; DIABETES-MELLITUS; OXIDATIVE STRESS; OBESITY;
   PROTECTION; NEPHRIN; MICROVESICLES; BIOENERGETICS; EXPRESSION; PEPTIDE
AB Metabolic syndrome (MetS) is associated with nutrient surplus and kidney hyperfiltration, accelerating chronic renal failure. The potential involvement of podocyte damage in early MetS remains unclear. Mitochondrial dysfunction is an important determinant of renal damage, but whether it contributes to MetS-related podocyte injury remains unknown. Domestic pigs were studied after 16 wk of diet-induced MetS, MetS treated with the mitochondria-targeted peptide elamipretide (ELAM; 0.1 mg.kg(-1).day(-1) sc) for the last month of diet, and lean controls (n = 6 pigs/group). Glomerular filtration rate (GFR) and renal blood flow (RBF) were measured using multidetector computed tomography, and podocyte and mitochondrial injury were measured by light and electron microscopy. Urinary levels of podocyte-derived extracellular vesicles (pEVs; nephrin positive/podocalyxin positive) were characterized by flow cytometry. Body weight, blood pressure, RBF, and GFR were elevated in MetS. Glomerular size and glomerular injury score were also elevated in MetS and decreased after ELAM treatment. Evidence of podocyte injury, impaired podocyte mitochondria, and foot process width were all increased in MetS but restored with ELAM. The urinary concentration of pEVs was elevated in MetS pigs and directly correlated with renal dysfunction, glomerular injury, and fibrosis and inversely correlated with glomerular nephrin expression. Additionally, pEV numbers were elevated in the urine of obese compared with lean human patients. Early MetS induces podocyte injury and mitochondrial damage, which can be blunted by mitoprotection. Urinary pEVs reflecting podocyte injury might represent early markers of MetS-related kidney disease and a novel therapeutic target.
C1 [Zhang, Li-Hong; Zhu, Xiang-Yang; Eirin, Alfonso; Nargesi, Arash Aghajani; Woollard, John R.; Santelli, Adrian; Sun, In O.; Textor, Stephen C.; Lerman, Lilach O.] Mayo Clin, Div Nephrol & Hypertens, 200 First St SW, Rochester, MN 55905 USA.
   [Zhang, Li-Hong] Fudan Univ, Peoples Hosp Shanghai 5, Dept Nephrol, Shanghai, Peoples R China.
C3 Mayo Clinic; Fudan University
RP Lerman, LO (corresponding author), Mayo Clin, Div Nephrol & Hypertens, 200 First St SW, Rochester, MN 55905 USA.
EM Lerman.Lilach@mayo.edu
RI Eirin, Alfonso/N-9873-2013; Lerman, Lilach/M-4962-2017; Nargesi,
   Arash/AAM-5298-2020
OI Eirin, Alfonso/0000-0002-3864-9644
FU Stealth Biotherapeutics; National Institutes of Health [DK-120242,
   DK-100081, DK-106427, DK-104273, HL-123160, DK-102325]
FX This work was supported by a research grant from Stealth Biotherapeutics
   and by National Institutes of Health Grants DK-120242, DK-100081,
   DK-106427, DK-104273, HL-123160, and DK-102325.
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NR 48
TC 30
Z9 34
U1 2
U2 11
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 1931-857X
EI 1522-1466
J9 AM J PHYSIOL-RENAL
JI Am. J. Physiol.-Renal Physiol.
PD JUL
PY 2019
VL 317
IS 1
BP F12
EP F22
DI 10.1152/ajprenal.00399.2018
PG 11
WC Physiology; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology; Urology & Nephrology
GA IK5WE
UT WOS:000476655300002
PM 31042059
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Taher, R
   Sara, JD
   Heidari, B
   Toya, T
   Lerman, LO
   Lerman, A
AF Taher, Riad
   Sara, Jaskanwal D.
   Heidari, Behnam
   Toya, Takumi
   Lerman, Lilach O.
   Lerman, Amir
TI Metabolic syndrome is associated with peripheral endothelial dysfunction
   amongst men
SO DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
LA English
DT Article
DE metabolic syndrome; peripheral endothelial dysfunction; reactive
   hyperemia peripheral arterial tonometry; cardiovascular disease
ID INTERNATIONAL-DIABETES-FEDERATION; CARDIOVASCULAR EVENTS; WAIST
   CIRCUMFERENCE; HEART; PREVENTION; MORTALITY; CRITERIA; DISEASE; STRESS;
   ADULTS
AB Purpose: Metabolic syndrome (MetS) and peripheral endothelial dysfunction (PED) are both independently associated with an increased risk of cardiovascular disease (CVD). PED provides prognostic information beyond that provided by conventional risk factors. However, the association between MetS and PED remains uncertain. We evaluated the association between MetS and PED.
   Patients and methods: We performed a retrospective analysis of patients who were referred to Mayo Clinic between 2006 and 2014 for evaluation of chest pain and/or an assessment of CVD risk that included an assessment of PED measured with reactive hyperemia peripheral arterial tonometry. MetS was defined as the presence of at least 3 of the following: body mass index >= 25 kg/m(2), impaired fasting glucose or diabetes, high blood pressure or hypertension, hypertriglyceridemia, or low high-density lipoprotein cholesterol.
   Results: Six hundred seventy-eight patients were included (mean age 51.9 +/- 13.5 years, 418 (61.6%) women), of which 293 (43.2%) had PED, and 249 (36.7%) had MetS. In multivariable analyses adjusted for age, sex, CVD, smoking status, and elevated low-density lipoprotein, MetS was significantly associated with PED (Odds Ratio (OR) 2.06; P=0.0090). Of the individual MetS components, only being overweight and MetS range high-density lipoprotein had a similar association. After stratifying by sex, the association between MetS and PED persisted only in men (OR 3.16, P=0.0094).
   Conclusions: MetS is associated with PED in men undergoing an assessment of chest pain and/ or CVD risk. Identifying PED in individuals with MetS could provide an abridged assessment of risk, potentially allowing for earlier and more intensive management of risk factors.
C1 [Taher, Riad; Sara, Jaskanwal D.; Heidari, Behnam; Toya, Takumi; Lerman, Amir] Mayo Clin, Coll Med & Sci, Div Cardiovasc Dis, 200 1st St SW, Rochester, MN 55902 USA.
   [Lerman, Lilach O.] Mayo Clin, Coll Med & Sci, Div Nephrol & Hypertens, Dept Med, Rochester, MN USA.
C3 Mayo Clinic; Mayo Clinic
RP Lerman, A (corresponding author), Mayo Clin, Coll Med & Sci, Div Cardiovasc Dis, 200 1st St SW, Rochester, MN 55902 USA.
EM Lerman.amir@mayo.edu
RI Lerman, Lilach/M-4962-2017
OI Taher, Riad/0000-0002-7419-0498; Toya, Takumi/0000-0002-4681-2798
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NR 30
TC 13
Z9 13
U1 0
U2 1
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-7007
J9 DIABETES METAB SYNDR
JI Diabetes Metab. Syndr. Obes.
PY 2019
VL 12
BP 1035
EP 1045
DI 10.2147/DMSO.S204666
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA IJ2SQ
UT WOS:000475755600001
PM 31308718
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Michalakis, K
   Mintziori, G
   Kaprara, A
   Tarlatzis, BC
   Goulis, DG
AF Michalakis, Konstantinos
   Mintziori, Gesthimani
   Kaprara, Athina
   Tarlatzis, Basil C.
   Goulis, Dimitrios G.
TI The complex interaction between obesity, metabolic syndrome and
   reproductive axis: A narrative review
SO METABOLISM-CLINICAL AND EXPERIMENTAL
LA English
DT Review
DE Metabolic syndrome; Obesity; Reproductive Axis; Hypogonadism;
   Subfertility
ID BODY-MASS INDEX; HORMONE-BINDING GLOBULIN; ANTI-MULLERIAN HORMONE;
   PLASMA GHRELIN LEVELS; INHIBIN-B LEVELS; MIDDLE-AGED MEN; NORMALIZES
   SERUM TESTOSTERONE; POLYCYSTIC-OVARY-SYNDROME; SOLUBLE LEPTIN RECEPTOR;
   GLUCAGON-LIKE PEPTIDE-1
AB The aim of this narrative review is to provide current evidence for the interaction between obesity, metabolic syndrome (MS) and reproductive axis. Gonadotropin-releasing hormone (GnRH) pulses and, consequently, normal function of reproductive (hypothalamus-pituitary-gonadal) axis depend on normal energy balance, which presupposes sufficient food intake, reasonable energy consumption and average thermoregulatory costs. In case of an energy imbalance, reproductive dysfunction may occur. In young women, excessive leanness is accompanied by puberty delay, whereas premature puberty might be a manifestation of obesity. In a similar way, obesity in men affects fertility. Excess adipose tissue results in increased conversion of testosterone to estradiol, which may lead to secondary hypogonadism through reproductive axis suppression. Moreover, oxidative stress at the level of the testicular micro-environment may result in decreased spermatogenesis and sperm damage. Products of the adipocyte, such as leptin, adiponectin and resistin, and gut peptides, such as ghrelin, are considered to be crucial in the interaction between energy balance and reproduction. Finally, an indirect evidence for the interplay between MS and reproductive axis is the fact that when treating components of one, parameters of the other can be improved as well. These therapeutic interventions include lifestyle modifications, pharmacological agents, such as sex hormone replacement therapy, and surgical procedures. Although many issues remain unclear, the elucidation of the complex interaction between MS and reproductive axis will have obvious clinical implications in the therapeutic approach of both entities. (C) 2013 Elsevier Inc. All rights reserved.
C1 [Michalakis, Konstantinos] Univ Athens, Sch Med, Laikon Univ Hosp, Dept Internal Med 1, GR-10679 Athens, Greece.
   [Mintziori, Gesthimani; Kaprara, Athina; Tarlatzis, Basil C.; Goulis, Dimitrios G.] Aristotle Univ Thessaloniki, Sch Med, Dept Obstet & Gynecol 1, Unit Reprod Endocrinol, Thessaloniki, Greece.
C3 National & Kapodistrian University of Athens; Laiko General Hospital;
   Athens Medical School; Aristotle University of Thessaloniki
RP Goulis, DG (corresponding author), Papageorgiou Gen Hosp, Dept Obstet & Gynecol 1, Unit Reprod Endocrinol, Ring Rd, Thessaloniki 54601, Greece.
EM dimitrios.goulis@otenet.gr
RI Tarlatzis, Basil/M-6964-2013; Mintziori, Gesthimani/H-8491-2019; Goulis,
   Dimitrios/AAG-4589-2020
OI Goulis, Dimitrios/0000-0002-5005-1995
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NR 258
TC 221
Z9 244
U1 2
U2 108
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0026-0495
EI 1532-8600
J9 METABOLISM
JI Metab.-Clin. Exp.
PD APR
PY 2013
VL 62
IS 4
BP 457
EP 478
DI 10.1016/j.metabol.2012.08.012
PG 22
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 125HL
UT WOS:000317530800001
PM 22999785
DA 2025-06-11
ER

PT J
AU Cardinali, DP
   Pagano, ES
   Bernasconi, PAS
   Reynoso, R
   Scacchi, P
AF Cardinali, Daniel P.
   Pagano, Eleonora S.
   Scacchi Bernasconi, Pablo A.
   Reynoso, Roxana
   Scacchi, Pablo
TI Disrupted chronobiology of sleep and cytoprotection in obesity: possible
   therapeutic value of melatonin
SO NEUROENDOCRINOLOGY LETTERS
LA English
DT Review
DE sleep; metabolic syndrome; diabetes; obesity; neuroimmunology;
   melatonin; cytokines; circadian rhythms; inflammation; free radicals
ID HIGH-FAT DIET; CIRCADIAN-RHYTHMS; BLOOD-PRESSURE; GENE-EXPRESSION; ORAL
   MELATONIN; BODY-WEIGHT; METABOLIC SYNDROME; OXIDATIVE STRESS;
   GROWTH-HORMONE; LIPID PROFILE
AB From a physiological perspective the sleep-wake cycle can be envisioned as a sequence of three physiological states (wakefulness, non-rapid eye movement, NREM, sleep and REM sleep) which are defined by a particular neuroendocrine-immune profile regulating the metabolic balance, body weight and inflammatory responses. Sleep deprivation and circadian disruption in contemporary "24/7 Society" lead to the predominance of pro-orexic and proinflammatory mechanisms that contribute to a pandemic metabolic syndrome (MS) including obesity, diabetes and atherosclerotic disease. Thus, a successful management of MS may require a drug that besides antagonizing the trigger factors of MS could also correct a disturbed sleep-wake rhythm. This review deals with the analysis of the therapeutic validity of melatonin in MS. Melatonin is an effective chronobiotic agent changing the phase and amplitude of the sleep/wake rhythm and having cytoprotective and immunomodulatory properties useful to prevent a number of MS sequels. Several studies support that melatonin can prevent hyperadiposity in animal models of obesity. Melatonin at a low dose (2-5 mg/day) has been used for improving sleep in patients with insomnia and circadian rhythm sleep disorders. More recently, attention has been focused on the development of potent melatonin analogs with prolonged effects (ramelteon, agomelatine, tasimelteon, TK 301). In clinical trials these analogs were employed in doses considerably higher than those usually employed for melatonin. In view that the relative potencies of the analogs are higher than that of the natural compound, clinical trials employing melatonin doses in the range of 50-100 mg/day are needed to assess its therapeutic value in MS.
C1 [Cardinali, Daniel P.] Pontificia Univ Catolica Argentina, UCA, Fac Ciencias Med, Dept Docencia & Invest, Buenos Aires, DF, Argentina.
C3 Pontificia Universidad Catolica Argentina
RP Cardinali, DP (corresponding author), Pontificia Univ Catolica Argentina, UCA, Fac Ciencias Med, Dept Docencia & Invest, Av Alicia Moreau de Justo 1500,4 Piso,C1107AFD, Buenos Aires, DF, Argentina.
EM danielcardinali@uca.edu.ar
FU Agencia Nacional de Promocion Cientifica y Tecnologica, Argentina [PICT
   2007-01045]; University of Buenos Aires [M006]; Argentine Research
   Council (CONICET); University of Buenos Aires; CONICET
FX Studies in authors' laboratories were supported by grants from the
   Agencia Nacional de Promocion Cientifica y Tecnologica, Argentina (PICT
   2007-01045) and the University of Buenos Aires (M006). DPC is a Research
   Career Awardee from the Argentine Research Council (CONICET) and
   Professor Emeritus, University of Buenos Aires. ESP and PS are Research
   Career Awardees from CONICET.
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NR 216
TC 23
Z9 25
U1 2
U2 10
PU MAGHIRA & MAAS PUBLICATIONS
PI MUNSBACH
PA MAGHIRA & MAAS S A R L, 6C, RUE GABRIEL LIPPMANN, L-5365 MUNSBACH,
   LUXEMBOURG
SN 0172-780X
EI 2354-4716
J9 NEUROENDOCRINOL LETT
JI Neuroendocrinol. Lett.
PY 2011
VL 32
IS 5
BP 588
EP 606
PG 19
WC Endocrinology & Metabolism; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology
GA 896CV
UT WOS:000300543900003
PM 22167135
DA 2025-06-11
ER

PT J
AU Razny, U
   Wator, L
   Polus, A
   Kiec-Wilk, B
   Wan, YJY
   Dyduch, G
   Tomaszewska, R
   Dembinska-Kiec, A
AF Razny, Urszula
   Wator, Lukasz
   Polus, Anna
   Kiec-Wilk, Beata
   Wan, Yu-Jui Yvonne
   Dyduch, Grzegorz
   Tomaszewska, Romana
   Dembinska-Kiec, Aldona
TI Modulatory effect of high saturated fat diet-induced metabolic
   disturbances on angiogenic response in hepatocyte RXRα knockout mice
SO PHARMACOLOGICAL REPORTS
LA English
DT Article
DE angiogenesis; adipogenesis; apoptosis; metabolic syndrome; microarray;
   RXR alpha ko
ID X-RECEPTOR-ALPHA; GROWTH-FACTOR VEGF; PROTEIN-KINASE-C;
   ENDOTHELIAL-CELLS; ARACHIDONIC-ACID; OXIDATIVE STRESS; DEFICIENT MICE;
   ADIPOGENESIS; ACTIVATION; OBESITY
AB Metabolic syndrome and diabetes lead to pathological angiogenesis and angiopathy. Metabolic disturbances occur as an effect of genetic and environmental interaction. Hyperleptinemia accompanies obesity and leptin is a potent proangiogenic factor. The aim of the study was to investigate the effect of high fat diet-induced alterations in gene expression and angiogenic response in the hRXR alpha ko mice lacking of hyperglycemia.
   hRXR alpha ko and control mice were fed either standard or high saturated fat (HF) diet for 7 weeks. Body weight and biochemical parameters (glucose, triglycerides, cholesterol), insulin and adipokines (leptin, adiponectin) were monitored. At sixth week of feeding, mice were subcutaneously injected for 6 days with matrigel containing bFGF. Then, matrigel plugs were used for immunohistochemical staining of cells with CD31 antibody and gene expression assessment (by microarray confirmed for some genes with quantitative real time PCR). For description of angiogenesis CD31 positive structures were counted in the matrigel sections. HF diet feeding of the hRXRa ko mice resulted in increased serum cholesterol and leptin level and in tendency to decrease angiogenesis (number of vessels with lumen). The microarray studies revealed that HF diet down-regulated genes related to angiogenesis (Nos3, Kdr) and up-regulated genes connected with apoptosis (activators of caspase 3, proapoptotic genes Bcl2) and proinflammatory pathway (Nf kappa B pathway, Tnf alpha).
   Summing up, HF diet feeding of hRXR alpha ko mice resulted in dyslipidemia and hyperleptinemia as well as impaired angiogenic response, and cell apoptosis. These results argue for independent participation of dyslipidemia and hyperleptinemia in pathology of angiogenic response associating metabolic syndrome.
C1 [Razny, Urszula; Wator, Lukasz; Polus, Anna; Kiec-Wilk, Beata; Dembinska-Kiec, Aldona] Jagiellonian Univ, Coll Med, Dept Clin Biochem, PL-31501 Krakow, Poland.
   [Dyduch, Grzegorz; Tomaszewska, Romana] Jagiellonian Univ, Coll Med, Dept Pathomorphol, PL-31501 Krakow, Poland.
   [Wan, Yu-Jui Yvonne] Univ Kansas, Med Ctr, Dept Pharmacol Toxicol & Therapeut, Kansas City, KS 66160 USA.
C3 Jagiellonian University; Collegium Medicum Jagiellonian University;
   Jagiellonian University; Collegium Medicum Jagiellonian University;
   University of Kansas; University of Kansas Medical Center
RP Razny, U (corresponding author), Jagiellonian Univ, Coll Med, Dept Clin Biochem, Kopernika 15A, PL-31501 Krakow, Poland.
EM urazny@cm-uj.krakow.pl
RI Razny, Urszula/U-2550-2019
FU Polish Committee of Science [PBZ-MIN-005/P04/2002/5]; National
   Institutes of Health [CA53596, AA14147, COBRE P20 RR021940]; Molecular
   Biology Core under COBRE as well as the Liver Center at KUMC
FX We would like to thank Dr. Anna Knapp for kind help in preparation of
   this paper. Supported by Polish Committee of Science Grant No.
   PBZ-MIN-005/P04/2002/5, National Institutes of Health grants CA53596,
   AA14147, and COBRE P20 RR021940, the Molecular Biology Core under COBRE
   as well as the Liver Center at KUMC.
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NR 35
TC 4
Z9 4
U1 0
U2 2
PU POLISH ACAD SCIENCES INST PHARMACOLOGY
PI KRAKOW
PA SMETNA 12, 31-343 KRAKOW, POLAND
SN 1734-1140
J9 PHARMACOL REP
JI Pharmacol. Rep.
PD NOV-DEC
PY 2010
VL 62
IS 6
BP 1078
EP 1089
PG 12
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 727VB
UT WOS:000287829800012
PM 21273665
DA 2025-06-11
ER

PT J
AU Xu, XB
   Jhun, BS
   Ha, CH
   Jin, ZG
AF Xu, Xiangbin
   Jhun, Bong Sook
   Ha, Chang Hoon
   Jin, Zheng-Gen
TI Molecular mechanisms of ghrelin-mediated endothelial nitric oxide
   synthase activation
SO ENDOCRINOLOGY
LA English
DT Article
ID PROTEIN-KINASE-B; PLASMA GHRELIN; SHEAR-STRESS; NO SYNTHASE; CIRCULATING
   GHRELIN; INSULIN-RESISTANCE; HEART-FAILURE; HUMAN OBESITY; IN-VIVO; AMP
AB Metabolic syndrome accelerates the atherosclerotic process, and the earliest event of which is endothelial dysfunction. Ghrelin, a newly discovered gastric peptide, improves endothelial function and inhibits proatherogenic changes. In particular, low ghrelin concentration has been associated with several features of metabolic syndrome, including obesity, insulin resistance, and high blood pressure. However, the molecular mechanisms underlying ghrelin vascular actions remain largely unclear. Here, we showed that ghrelin activated endothelial nitric oxide (NO) synthase (eNOS) in cultured endothelial cells (ECs) and in intact vessels. Specifically, ghrelin rapidly induced phosphorylation of eNOS on an activation site and production of NO in human umbilical vein ECs and bovine aortic ECs. The eNOS phosphorylation was also observed in mouse aortas ex vivo perfused with ghrelin and in aortic tissues isolated from mice injected with ghrelin. Mechanistically, ghrelin stimulated AMP-activated protein kinase (AMPK) and Akt activation in cultured ECs and intact vessels. Inhibiting AMPK and Akt with their pharmacological inhibitors, small interference RNA and adenoviruses carried dominant-negative mutants, markedly attenuated ghrelin-induced eNOS activation, and NO production. Furthermore, ghrelin receptor/Gq protein/ calcium-dependent pathway mediates activation of AMPK, Akt, and eNOS, and calmodulin-dependent kinase kinase is a potential convergent point to regulate Akt and AMPK activation in ghrelin signaling. Importantly, eNOS activation is critical for ghrelin inhibition of vascular inflammation. Together, both in vitro and in vivo data demonstrate a new role of ghrelin signaling for eNOS activation, and highlight the therapeutic potential for ghrelin to correct endothelial dysfunction associated with atherosclerotic vascular diseases and metabolic syndrome.
C1 [Jin, Zheng-Gen] Univ Rochester, Med Ctr, Aab Cardiovasc Res Inst, Dept Med, Rochester, NY 14642 USA.
C3 University of Rochester
RP Jin, ZG (corresponding author), Univ Rochester, Med Ctr, Aab Cardiovasc Res Inst, Dept Med, 601 Elmwood Ave, Rochester, NY 14642 USA.
EM zheng-gen_jin@urmc.rochester.edu
RI Ha, C/GZL-9046-2022; zhang, wenjing/AAE-7146-2019
OI Jhun, Bong Sook/0000-0001-9916-9962
FU NHLBI NIH HHS [R01 HL080611, R01 HL-080611] Funding Source: Medline
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NR 49
TC 90
Z9 98
U1 0
U2 5
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0013-7227
EI 1945-7170
J9 ENDOCRINOLOGY
JI Endocrinology
PD AUG
PY 2008
VL 149
IS 8
BP 4183
EP 4192
DI 10.1210/en.2008-0255
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 329AV
UT WOS:000257840200047
PM 18450953
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Karbowska, Z
   Cierpiszewska, K
   Maruszczak, K
   Sukhachova, I
   Szwankowska, D
   Piotrowski, I
AF Karbowska, Zuzanna
   Cierpiszewska, Katarzyna
   Maruszczak, Klara
   Sukhachova, Ivanna
   Szwankowska, Dominika
   Piotrowski, Igor
TI Impact of testosterone levels and testosterone replacement therapy on
   men's health
SO JOURNAL OF MEDICAL SCIENCE
LA English
DT Review
DE testosterone; testosterone de ficiency; functional hypogonadism;
   late-onset hypogonadism (LOH); testosterone replacement therapy (TRT)
ID HORMONE-BINDING GLOBULIN; METABOLIC SYNDROME; CARDIOVASCULAR EVENTS;
   DEFICIENCY SYNDROME; PROSTATE-CANCER; SEX-DIFFERENCES; RISK; MORTALITY;
   SPERMATOGENESIS; ERYTHROCYTOSIS
AB Various studies have shown that testosterone levels have a heavy impact on areas of a man's health. Low serum testosterone (and, by analogy, late -onset hypogonadism) may be responsible for such conditions as type 2 diabetes, obesity in the abdominal area, and, most of all, heightened cardiovascular risk (CV). Among other outcomes, researchers have pointed out metabolic syndrome and dyslipidemia, as well as an increased risk of anxiety disorders and major depressive disorders. There have also been reports of testosterone's influence on fertility, bone mineral density, and the development of polycythemia. Low testosterone can have a variety of effects, all of which increase the risk of premature death by raising inflammatory marker levels. Overly high testosterone, however, has been proven to have a notable influence on men's personalities, as well as other psychological and social traits, both in endogenously elevated testosterone levels and in patients with a history of anabolic-androgenic steroid use. The last decade's research on testosterone's impact on the organism has yielded contradictory results. Therefore, examination and understanding of the influence of its abnormal levels prove essential to not only guarantee the best quality of hypogonadism treatment but also to ef ficiently prevent any side effects or complications associated with testosterone use.
C1 [Karbowska, Zuzanna; Cierpiszewska, Katarzyna; Maruszczak, Klara; Sukhachova, Ivanna; Szwankowska, Dominika] Poznan Univ Med Sci, Fac Med, Poznan, Poland.
   [Piotrowski, Igor] Greater Poland Canc Ctr, Radiobiol Labs, Dept Med Phys, Poznan, Poland.
C3 Poznan University of Medical Sciences; Wielkopolskie Centrum Onkologii
RP Karbowska, Z (corresponding author), Poznan Univ Med Sci, Fac Med, Poznan, Poland.
EM zuzanna.karbowska99@gmail.com
RI Cierpiszewska, Katarzyna/MIP-1004-2025
OI Piotrowski, Igor/0000-0002-4985-9321
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NR 78
TC 0
Z9 0
U1 1
U2 2
PU POZNAN UNIV MEDICAL SCIENCES
PI Poznan
PA 10 Fredry Street, Poznan, POLAND
SN 2353-9798
EI 2353-9801
J9 J MED SCI-POLAND
JI J. Med. Sci.
PY 2024
VL 93
IS 1
BP 57
EP 68
DI 10.20883/medical.e856
PG 12
WC Medicine, General & Internal; Medicine, Research & Experimental
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine; Research & Experimental Medicine
GA QS1N9
UT WOS:001222769400001
OA gold
DA 2025-06-11
ER

PT J
AU Chaudhary, K
   Malhotra, K
   Sowers, J
   Aroor, A
AF Chaudhary, Kunal
   Malhotra, Kunal
   Sowers, James
   Aroor, Annayya
TI Uric Acid - Key Ingredient in the Recipe for Cardiorenal Metabolic
   Syndrome
SO CARDIORENAL MEDICINE
LA English
DT Review
DE Uric acid; Fructose; Cardiorenal metabolic syndrome; Chronic kidney
   disease
ID CHRONIC KIDNEY-DISEASE; INSULIN-RESISTANCE; DIABETES-MELLITUS;
   BLOOD-PRESSURE; ENDOTHELIAL FUNCTION; DIETARY FRUCTOSE; HEART-FAILURE;
   HYPERURICEMIA; ALLOPURINOL; HYPERTENSION
AB Elevated serum uric acid levels are a frequent finding in persons with obesity, hypertension, cardiovascular and kidney disease as well as in those with the cardiorenal metabolic syndrome (CRS). The increased consumption of a fructose-rich Western diet has contributed to the increasing incidence of the CRS, obesity and diabetes especially in industrialized populations. There is also increasing evidence that supports a causal role of high dietary fructose driving elevations in uric acid in association with the CRS. Animal and epidemiological studies support the notion that elevated serum uric acid levels play an important role in promoting insulin resistance and hypertension and suggest potential pathophysiological mechanisms that contribute to the development of the CRS and associated cardiovascular disease and chronic kidney disease. To this point, elevated serum levels of uric acid appear to contribute to impaired nitric oxide production/endothelial dysfunction, increased vascular stiffness, inappropriate activation of the renin-angiotensin-aldosterone system, enhanced oxidative stress, and maladaptive immune and inflammatory responses. These abnormalities, in turn, promote vascular, cardiac and renal fibrosis as well as associated functional abnormalities. Small clinical trials have suggested that uric acid-lowering therapies may be beneficial in such patients; however, a consensus on the treatment of asymptomatic hyperuricemia is lacking. Larger randomized controlled trials need to be performed in order to critically evaluate the beneficial effect of lowering serum uric acid in patients with the CRS and those with diabetes and/or hypertension. (C) 2013 S. Karger AG, Basel
C1 [Chaudhary, Kunal; Sowers, James; Aroor, Annayya] Univ Missouri, Harry S Truman Vet Hosp, Columbia, MO USA.
   [Chaudhary, Kunal; Malhotra, Kunal] Univ Missouri, Dept Med, Div Endocrinol, Columbia, MO USA.
   [Sowers, James; Aroor, Annayya] Univ Missouri, Div Endocrinol, Columbia, MO USA.
   [Sowers, James] Univ Missouri, Dept Med Pharmacol & Physiol, Columbia, MO USA.
C3 US Department of Veterans Affairs; Veterans Health Administration (VHA);
   Harry S. Truman Memorial Veterans' Hospital; University of Missouri
   System; University of Missouri Columbia; University of Missouri System;
   University of Missouri Columbia; University of Missouri System;
   University of Missouri Columbia; University of Missouri System;
   University of Missouri Columbia
RP Aroor, A (corresponding author), D109 Diabet Ctr UHC, 1 Hosp Dr, Columbia, MO 65212 USA.
EM aroora@health.missouri.edu
RI Malhotra, Kunal/R-2228-2018
OI Malhotra, Kunal/0000-0002-3209-8140
FU National Institutes of Health [R01-HL73101, R01-HL1079100]; Veterans
   Affairs Merit System [0018]
FX This research was supported by the National Institutes of Health
   (R01-HL73101 and R01-HL1079100) and Veterans Affairs Merit System 0018.
   The authors wish to thank Brenda Hunter for her assistance.
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NR 67
TC 158
Z9 176
U1 2
U2 39
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1664-3828
EI 1664-5502
J9 CARDIORENAL MED
JI CardioRenal Med.
PY 2013
VL 3
IS 3
BP 208
EP 220
DI 10.1159/000355405
PG 13
WC Cardiac & Cardiovascular Systems; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Urology & Nephrology
GA 236WZ
UT WOS:000325831500004
PM 24454316
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Kishi, T
   Hirooka, Y
   Konno, S
   Sunagawa, K
AF Kishi, Takuya
   Hirooka, Yoshitaka
   Konno, Satomi
   Sunagawa, Kenji
TI Angiotensin II receptor blockers improve endothelial dysfunction
   associated with sympathetic hyperactivity in metabolic syndrome
SO JOURNAL OF HYPERTENSION
LA English
DT Article
DE angiotensin II; autonomic function; endothelial function; metabolic
   syndrome
ID ROSTRAL VENTROLATERAL MEDULLA; DEPENDENT VASODILATION;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; NERVOUS-SYSTEM; BLOOD-PRESSURE;
   HEART-RATE; URIC-ACID; HYPERTENSION; OBESITY
AB Objectives: Renin-angiotensin system inhibitors are preferred for the treatment of hypertension with metabolic syndrome (MetS). Underlying endothelial dysfunction and sympathetic nervous system (SNS) activation are critically involved in the pathogenesis of hypertension in MetS. We investigated whether treatment with angiotensin II type 1 receptor blockers (ARBs) improves endothelial and autonomic function in patients with MetS.
   Methods and results: We conducted a prospective, randomized, open-label, blinded endpoint trial. Sixty patients with MetS were randomized into three treatment groups: telmisartan, candesartan, or diet therapy (control; n = 20 each), and treated for 6 months. To evaluate the endothelial function of forearm resistance arteries, blood flow and vascular resistance were measured using a strain-gauge plethysmograph during intra-arterial infusion of acetylcholine (ACh) or sodium nitroprusside (SNP). At 6 months, both telmisartan and candesartan comparably decreased blood pressure. Furthermore, ARB treatment ameliorated impaired forearm vasodilation in response to ACh. Telmisartan had a greater effect than candesartan on ACh-induced forearm vasodilation. In contrast, forearm vasodilation in response to SNP was comparable between the telmisartan and candesartan-treated groups. ARB treatment increased high-molecular-weight (HMW) adiponectin levels and baroreflex sensitivity, but telmisartan had a stronger effect than candesartan. In addition, only telmisartan treatment significantly decreased plasma norepinephrine concentrations, blood pressure variability, and heart rate variability based on spectral analysis.
   Conclusion: These findings indicate that ARBs improve impaired endothelial and baroreflex function, and increase HMW adiponectin levels in patients with MetS. Telmisartan exhibited more beneficial effects than candesartan, and only telmisartan reduced sympathetic hyperactivity, despite similar depressor effects.
C1 [Hirooka, Yoshitaka] Kyushu Univ, Grad Sch Med Sci, Dept Adv Cardiovasc Regulat & Therapeut, Higashi Ku, Fukuoka 8128582, Japan.
   [Kishi, Takuya] Kyushu Univ, Grad Sch Med Sci, Dept Adv Therapeut Cardiovasc Dis, Fukuoka 8128582, Japan.
   [Konno, Satomi; Sunagawa, Kenji] Kyushu Univ, Grad Sch Med Sci, Dept Cardiovasc Med, Fukuoka 8128582, Japan.
C3 Kyushu University; Kyushu University; Kyushu University
RP Hirooka, Y (corresponding author), Kyushu Univ, Grad Sch Med Sci, Dept Adv Cardiovasc Regulat & Therapeut, Higashi Ku, 3-1-1 Maidashi, Fukuoka 8128582, Japan.
EM hyoshi@cardiol.med.kyushu-u.ac.jp
RI Kishi, Takuya/ITU-1075-2023
FU Japan Society for the Promotion of Science [B193290231]; Kimura Memorial
   Foundation Research Grant
FX The study was supported by a Grant-in-Aid for Scientific Research from
   the Japan Society for the Promotion of Science (B193290231) and in part
   by a Kimura Memorial Foundation Research Grant.
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NR 50
TC 37
Z9 38
U1 0
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0263-6352
EI 1473-5598
J9 J HYPERTENS
JI J. Hypertens.
PD AUG
PY 2012
VL 30
IS 8
BP 1646
EP 1655
DI 10.1097/HJH.0b013e328355860e
PG 10
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 973PE
UT WOS:000306371400022
PM 22728908
DA 2025-06-11
ER

PT J
AU Lopez-Huertas, E
AF Lopez-Huertas, Eduardo
TI The effect of EPA and DHA on metabolic syndrome patients: a systematic
   review of randomised controlled trials
SO BRITISH JOURNAL OF NUTRITION
LA English
DT Review
DE systematic review; metabolic syndrome; very long chain n3 fatty acids;
   cardiovascular disease
ID N-3 FATTY-ACIDS; ENDOTHELIAL ADHESION MOLECULES; SERUM AMYLOID-A;
   DIETARY-FAT; CARDIOVASCULAR-DISEASE; FISH CONSUMPTION; OLEIC-ACID;
   DOCOSAHEXAENOIC ACIDS; LIPOPROTEIN PROFILE; OXIDATIVE STRESS
AB Metabolic syndrome (MS) is characterised by accumulation of CVD risk factors. The use of very long chain n-3 polyunsaturated fatty acids (VLC n3 PUFA) could potentially benefit MS by reducing risk factors. To better understand the possible VLC n3 PUFA benefits, the literature was systematically reviewed for randomised controlled trials (RCT) that published effects of VLC n3 PUFA on MS patients. 17 RCT fulfilled the inclusion criteria and were analysed for relevance to the research question. The available RCT convincingly show that the administration of VLC n3 PUFA doses. 1 g for at least 3 months produces a significant reduction of triglycerides ranging from 7% to 25 %. These results confirm the hypotriglyceridemic effect of VLC n3 PUFA in MS patients. The triglyceride lowering may produce further benefits by reducing the % of pro-atherogenic small dense LDL particles (sdLDL) and also perhaps by ameliorating the inflammatory process associated with MS. High doses of VLC n3 PUFA (>= 3 g/day) may produce further TAG reductions but could raise other risk factors such as LDL-C. No clear effects were found on other MS markers. The combination of VLC n3 PUFA plus a statin may be useful to prevent the occurrence of coronary events. More studies are needed using different amounts of VLC n3 PUFA, time lengths, dietary backgrounds and different profiles of MS patients before clear recommendations can be made.
C1 CSIC, Estn Expt Zaidin, Spanish Minist Econ Affairs & Competitiveness Pro, E-18008 Granada, Spain.
C3 Spanish Ministry of Economy & Competitiveness; Consejo Superior de
   Investigaciones Cientificas (CSIC); CSIC - Estacion Experimental del
   Zaidin (EEZ)
RP Lopez-Huertas, E (corresponding author), CSIC, Estn Expt Zaidin, Spanish Minist Econ Affairs & Competitiveness Pro, E-18008 Granada, Spain.
EM eduardo.lopezhuertas@eez.csic.es
RI LOPEZ-HUERTAS, EDUARDO/L-3156-2014
OI LOPEZ-HUERTAS, EDUARDO/0000-0003-3403-3399
CR [Anonymous], COCHRANE LIB
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NR 76
TC 70
Z9 77
U1 0
U2 28
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1145
EI 1475-2662
J9 BRIT J NUTR
JI Br. J. Nutr.
PD JUN
PY 2012
VL 107
SU 2
BP S185
EP S194
DI 10.1017/S0007114512001572
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 943PT
UT WOS:000304137500016
PM 22591892
OA Bronze
DA 2025-06-11
ER

PT J
AU Johnson, DW
   Armstrong, K
   Campbell, SB
   Mudge, DW
   Hawley, CM
   Coombes, JS
   Prins, JB
   Isbel, NM
AF Johnson, David W.
   Armstrong, Kirsten
   Campbell, Scott B.
   Mudge, David W.
   Hawley, Carmel M.
   Coombes, Jeff S.
   Prins, Johannes B.
   Isbel, Nicole M.
TI Metabolic syndrome in severe chronic kidney disease: Prevalence,
   predictors, prognostic significance and effects of risk factor
   modification
SO NEPHROLOGY
LA English
DT Article
DE haemodialysis; insulin resistance; obesity; outcome; peritoneal
   dialysis; randomized controlled trial
ID INSULIN-RESISTANCE; MORTALITY; EPIDEMIOLOGY; ADIPONECTIN; DEFINITION;
   OBESITY
AB Background: Metabolic syndrome (MS) is a significant risk factor for cardiovascular disease, mortality and chronic kidney disease (CKD) in the general population. However, the prevalence, predictors, prognostic value and treatment of MS in the CKD population have not been rigorously studied.
   Methods: The study involved 200 stages 4 and 5 CKD patients enrolled in a randomized controlled trial of intensive multiple risk factor modification (targeting hypercholesterolaemia, hyperhomocysteinaemia, anaemia and disordered bone mineral metabolism) versus usual care. Participants were followed for a median period of 22 months.
   Results: The overall prevalence of MS was 30.5%. MS was independently predicted by older age, peritoneal dialysis and Maori/Pacific Islander origin. When laboratory parameters were included as covariates, the only significant predictors of MS were higher serum malondialdehyde and lower serum adiponectin concentrations. MS was an independent predictor of time to composite end-point of cardiovascular death, acute coronary syndrome, revascularization, non-fatal stroke and amputation (adjusted hazard ratio 2.46, 95% Cl 1.17-5.18). No significant difference in cardiovascular event-free survival was observed in those allocated to intensive risk factor modification compared with usual care.
   Conclusion: Metabolic syndrome occurs in 30.5% of stages 4 and 5 CKD patients and is associated with older age, peritoneal dialysis, ethnicity, increased oxidative stress, lower serum adiponectin concentrations and a significantly increased risk of future cardiovascular events. Intervention strategies targeting hypercholesterolaemia, hyperhomocysteinaemia, anaemia and disordered bone mineral metabolism may not be effective in ameliorating the heightened cardiovascular risk of CKD patients with MS.
C1 Univ Queensland, Princess Alexandra Hosp, Dept Renal Med, Brisbane, Qld 4102, Australia.
   Univ Queensland, Princess Alexandra Hosp, Dept Endocrinol, Brisbane, Qld 4102, Australia.
   Univ Queensland, Sch Human Movement Studies, Brisbane, Qld, Australia.
C3 University of Queensland; Princess Alexandra Hospital; University of
   Queensland; Princess Alexandra Hospital; University of Queensland
RP Johnson, DW (corresponding author), Univ Queensland, Princess Alexandra Hosp, Dept Renal Med, Level 12,Ambulatory Renal & Transplant Serv Bldg,, Brisbane, Qld 4102, Australia.
EM david_johnson@health.qld.gov.au
RI Campbell, Scott/H-8286-2013; Prins, Johannes/I-3610-2019; Isbel,
   Nicole/G-5604-2011; Hawley, Carmel/C-4905-2011; Prins,
   Johannes/M-5884-2013; Johnson, David/F-2897-2011; Mudge,
   David/C-1438-2011; Coombes, Jeff/F-1764-2010
OI Hawley, Carmel/0000-0002-1392-5649; Prins, Johannes/0000-0001-9497-927X;
   Johnson, David/0000-0001-5491-3460; Mudge, David/0000-0002-4112-5550;
   Coombes, Jeff/0000-0002-6990-3596
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NR 31
TC 108
Z9 123
U1 0
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1320-5358
EI 1440-1797
J9 NEPHROLOGY
JI Nephrology
PD AUG
PY 2007
VL 12
IS 4
BP 391
EP 398
DI 10.1111/j.1440-1797.2007.00804.x
PG 8
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 194VV
UT WOS:000248372800013
PM 17635756
DA 2025-06-11
ER

PT J
AU Witt, SH
   Buchmann, AF
   Blomeyer, D
   Nieratschker, V
   Treutlein, J
   Esser, G
   Schmidt, MH
   Bidlingmaier, M
   Wiedemann, K
   Rietschel, M
   Laucht, M
   Wüst, S
   Zimmermann, US
AF Witt, Stephanie H.
   Buchmann, Arlette F.
   Blomeyer, Dorothea
   Nieratschker, Vanessa
   Treutlein, Jens
   Esser, Guenter
   Schmidt, Martin H.
   Bidlingmaier, Martin
   Wiedemann, Klaus
   Rietschel, Marcella
   Laucht, Manfred
   Wuest, Stefan
   Zimmermann, Ulrich S.
TI An interaction between a neuropeptide Y gene polymorphism and early
   adversity modulates endocrine stress responses
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE GxE interaction; Stress; HPA; Neuropeptide Y; Early adversity
ID PITUITARY-ADRENAL AXIS; CORTICOTROPIN-RELEASING HORMONE;
   GLUCOCORTICOID-RECEPTOR GENE; SEROTONIN TRANSPORTER GENE; PSYCHOSOCIAL
   STRESS; HPA AXIS; CHILDHOOD EXPERIENCES; METABOLIC SYNDROME; PERCEIVED
   STRESS; RESTRAINT STRESS
AB Interindividual variability in the regulation of the human stress system accounts for a part of the individual's liability to stress-related diseases. These differences are influenced by environmental and genetic factors. Early childhood adversity is a well-studied environmental factor affecting an individual's stress response which has been shown to be modulated by gene environment interaction (GxE). Neuropeptide Y (NPY) plays a role in stress regulation and genetic variation in NPY may influence stress responses. In this study, we analyzed the association of a common variant in the NPY gene promoter, rs16147, with cortisol and ACTH responses to acute psychosocial stress in young adults from the Mannheim Study of Children at Risk (MARS), an ongoing epidemiological cohort study following the outcome of early adversity from birth into adulthood. We found evidence of a GxE interaction between rs16147 and early adversity significantly affecting HPA axis responses to acute psychosocial stress. These findings suggest that the neurobiological mechanisms linking early adverse experience and later neuroendocrine stress regulation are modulated by a gene variant whose functional relevance is documented by increasing convergent evidence from in vitro, animal and human studies. (C) 2011 Elsevier Ltd. All rights reserved.
C1 [Buchmann, Arlette F.; Blomeyer, Dorothea; Schmidt, Martin H.; Laucht, Manfred] Cent Inst Mental Hlth Mannheim, Dept Child & Adolescent Psychiat & Psychotherapy, D-68159 Mannheim, Germany.
   [Witt, Stephanie H.; Nieratschker, Vanessa; Treutlein, Jens; Rietschel, Marcella; Wuest, Stefan] Cent Inst Mental Hlth Mannheim, Dept Genet Epidemiol Psychiat, D-68159 Mannheim, Germany.
   [Esser, Guenter; Laucht, Manfred] Univ Potsdam, Dept Psychol, Div Clin Psychol, Potsdam, Germany.
   [Bidlingmaier, Martin] Univ Munich, Med Klin Innenstadt, Munich, Germany.
   [Wiedemann, Klaus] Univ Hamburg, Dept Psychiat & Psychotherapy, Univ Med Ctr Eppendorf, Hamburg, Germany.
   [Zimmermann, Ulrich S.] Cent Inst Mental Hlth, Dept Addict Behav & Addict Med, D-68159 Mannheim, Germany.
   [Zimmermann, Ulrich S.] Tech Univ Dresden, Dept Psychiat & Psychotherapy, Univ Hosp Carl Gustav Carus, Dresden, Germany.
C3 Central Institute of Mental Health; Central Institute of Mental Health;
   University of Potsdam; University of Munich; University of Hamburg;
   University Medical Center Hamburg-Eppendorf; Central Institute of Mental
   Health; Technische Universitat Dresden; Carl Gustav Carus University
   Hospital
RP Laucht, M (corresponding author), Cent Inst Mental Hlth Mannheim, Dept Child & Adolescent Psychiat & Psychotherapy, J5, D-68159 Mannheim, Germany.
EM manfred.laucht@zi-mannheim.de
RI Zimmermann, Ulrich/B-9357-2011
OI Bidlingmaier, Martin/0000-0002-4681-6668; Wust,
   Stefan/0000-0002-2315-8949
FU NGFNplus; German Research Foundation DFG [SFB636/Z4]
FX Funding for this study was provided by NGFNplus and the German Research
   Foundation DFG SFB636/Z4; neither founding source had any further role
   in study design; in the collection, analysis and interpretation of data;
   in the writing of the report; and in the decision to submit the paper
   for publication.
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NR 75
TC 41
Z9 43
U1 0
U2 11
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD AUG
PY 2011
VL 36
IS 7
BP 1010
EP 1020
DI 10.1016/j.psyneuen.2010.12.015
PG 11
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA 807VQ
UT WOS:000293931500008
PM 21273004
DA 2025-06-11
ER

PT J
AU Omidian, A
   Pourfarzam, M
   Ghanadian, SM
   Zadhoush, F
AF Omidian, Amin
   Pourfarzam, Morteza
   Ghanadian, Seyed Mostafa
   Zadhoush, Fouzieh
TI Determination of plasma and erythrocyte levels of copper, magnesium and
   zinc by atomic absorption spectrometry in type-2 diabetes mellitus
   patients with metabolic syndrome
SO RESEARCH IN PHARMACEUTICAL SCIENCES
LA English
DT Article
DE Atomic absorption spectrometry; Copper; Diabetes mellitus; Magnesium;
   Metabolic syndrome; Zinc
ID TRACE-ELEMENTS; BIOLOGICAL SAMPLES; OXIDATIVE STRESS; SERUM ZINC; BLOOD;
   CHROMIUM; ADULTS; IRON
AB Background and purpose: Imbalance in blood levels of trace elements is independent risk factor for metabolic syndrome (MetS), type 2 diabetes mellitus (T2DM), and its complications. This study investigated plasma and erythrocyte levels of copper, magnesium, zinc, and their correlations with biochemical components of the MetS in T2DM patients compared to the healthy controls.& nbsp;Experimental approach: Forty men recently diagnosed T2DM with MetS without complications and thirty six age-matched healthy controls were enrolled in this cross-sectional study. Plasma and erythrocyte levels of selected elements were measured by graphite furnace atomic absorption spectroscopy.& nbsp;Findings/Results: The results of the present study showed significantly lower plasma levels of copper, magnesium, and zinc and lower erythrocytes copper in the patients' group compared to the controls; while erythrocyte levels of magnesium and zinc were not significantly different between the two groups. Significant negative correlations were observed between plasma levels of copper with waist and hip circumferences, waist to hip ratio, systolic and diastolic blood pressures, fasting blood glucose, and glycated hemoglobin levels in all subjects; while erythrocyte copper levels showed significant negative correlation with triglyceride, and erythrocyte zinc was positively correlated with diastolic blood pressure and negatively with triglyceride.& nbsp;Conclusion and implications: Alterations of trace elements may have a significant role in the pathogenesis of MetS and T2DM patients. It is suggested that the body status of copper, magnesium, and zinc might be significantly correlated with components of MetS in T2DM patients; and plasma copper levels may be correlated with complications of type 2 diabetes mellitus.
C1 [Omidian, Amin; Pourfarzam, Morteza; Zadhoush, Fouzieh] Isfahan Univ Med Sci, Sch Pharm & Pharmaceut Sci, Dept Clin Biochem, Esfahan, Iran.
   [Ghanadian, Seyed Mostafa] Isfahan Univ Med Sci, Sch Pharm & Pharmaceut Sci, Dept Pharmacognosy, Esfahan, Iran.
C3 Isfahan University of Medical Sciences; Isfahan University of Medical
   Sciences
RP Zadhoush, F (corresponding author), Isfahan Univ Med Sci, Sch Pharm & Pharmaceut Sci, Dept Clin Biochem, Esfahan, Iran.
EM f.zadhoush@pharm.mui.ac.ir
RI zadhoush, fouzieh/S-4976-2018
FU Vice Chancellery for Research, Isfahan University of Medical Sciences,
   Isfahan, I.R. Iran [398690]
FX This study was financially supported by Vice Chancellery for Research,
   Isfahan University of Medical Sciences, Isfahan, I.R. Iran under Grant
   No. 398690. The authors would like to thank all the subjects who
   participated in this study.
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NR 35
TC 10
Z9 10
U1 1
U2 10
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, Maharashtra, INDIA
SN 1735-5362
EI 1735-9414
J9 RES PHARM SCI
JI Res. Pharm. Sci.
PD JAN-FEB
PY 2022
VL 17
IS 1
BP 86
EP 98
DI 10.4103/1735-5362.329929
PG 13
WC Chemistry, Medicinal
WE Emerging Sources Citation Index (ESCI)
SC Pharmacology & Pharmacy
GA WY9TQ
UT WOS:000719619600009
PM 34909047
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Zhao, LQ
   Liang, SY
   Li, CJ
   Yu, JY
   Zou, LH
   Xv, WC
   Qian, G
   Zhang, Y
   Huang, YX
   Li, YQ
AF Zhao, Liqin
   Liang, Shiyi
   Li, Chijian
   Yu, Jianye
   Zou, Lihao
   Xv, Weicheng
   Qian, Ge
   Zhang, Ying
   Huang, Yuxiang
   Li, Yongqiang
TI Ratios of peripheral blood mononuclear cells to lncRNA steroid receptor
   RNA activator as new indicators of metabolic syndrome
SO ENDOKRYNOLOGIA POLSKA
LA English
DT Article
DE lncRNA; steroid receptor RNA activator; peripheral blood mononuclear
   cells; metabolic syndrome; biomarkers
ID EXPRESSION
AB Introduction: Metabolic syndrome (MetS) is a clinical syndrome with several characteristics. Steroid receptor RNA activator (SRA) is a long non-coding RNA (lncRNA), which can increase the expression of steroid receptor-dependent gene. This study aimed to explore the changes in metabolic parameters and the predictive value of the peripheral blood mononuclear cells (PBMCs) to SRA ratios as new indicators in subjects with and without MetS in southern China.
   Material and methods: There were 81 participants (39 with MetS and 42 without MetS) in this cross-sectional study. The expression of lncRNAs in PBMCs was evaluated by quantitative reverse transcription polymerase chain reaction (qRT-PCR). The risks of SRA and PBMCs to SRA ratios contributing to the presence of MetS were estimated by univariate and multivariate logistic regression models. The area under the receiver (AUC) operating characteristic curve was employed to evaluate diagnostic accuracy.
   Results: MetS was positively correlated with cortisol, interleukin 6 (IL-6), white blood cell to SRA ratio (WTSR), lymphocyte to SRA ratio (LTSR), monocyte to SRA ratio (MTSR), and PBMC to SRA ratio (PTSR). A receiver operating characteristic (ROC) curve analysis was performed to assess the value of LTSR (OR: 0.722; p < 0.001) for predicting MetS. The area under the curve yielded a cut-off value of 0.483, with a sensitivity of 76.9% and a specificity of 71.4% (p < 0.001).
   Conclusion: In summary, SRA in PBMCs may be an important biomarker of stress reaction and may play a role in vulnerability to MetS. Also, the lymphocyte to SRA ratio demonstrated high accuracy in the diagnosis of MetS.
C1 [Zhao, Liqin] Southern Med Univ, Ctr Hlth Management, Affiliated Hosp 3, Guangzhou, Peoples R China.
   [Liang, Shiyi; Li, Chijian; Yu, Jianye; Zou, Lihao; Xv, Weicheng; Qian, Ge; Zhang, Ying] Southern Med Univ, Inst Nephrol & Urol, Dept Nephrol, Affiliated Hosp 3, Guangzhou, Peoples R China.
   [Huang, Yuxiang; Li, Yongqiang] Southern Med Univ, Dept Gen Med, Affiliated Hosp 3, Guangzhou, Peoples R China.
C3 Southern Medical University - China; Southern Medical University -
   China; Southern Medical University - China
RP Huang, YX; Li, YQ (corresponding author), Southern Med Univ, Dept Gen Med, Affiliated Hosp 3, Guangzhou, Peoples R China.
EM 1255856885@qq.com; liyongqiang851@163.com
FU President Foundation of The Third Affiliated Hospital of Southern
   Medical University [YQ2021016]; "Thirteenth Five-Year Plan" of Guangdong
   Province Educational Science [2020GXJK441]; Project of Traditional
   Chinese Medicine Bureau of Guangdong Province (CN) [20191228]; Science
   and Technology Planning Project of Huadu District, Guangzhou City
   [21-HDWS-059]
FX This work was supported by the President Foundation of The Third
   Affiliated Hospital of Southern Medical University(No. YQ2021016),
   "Thirteenth Five-Year Plan" of Guangdong Province Educational Science
   (No. 2020GXJK441), the Project of Traditional Chinese Medicine Bureau of
   Guangdong Province (CN) (No. 20191228 to ZY), Science and Technology
   Planning Project of Huadu District, Guangzhou City (No. 21-HDWS-059).
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NR 20
TC 0
Z9 0
U1 0
U2 3
PU VIA MEDICA
PI GDANSK
PA UL SWIETOKRZYSKA 73, 80-180 GDANSK, POLAND
SN 0423-104X
J9 ENDOKRYNOL POL
JI Endokrynol. Pol.
PY 2022
VL 73
IS 1
BP 81
EP 86
DI 10.5603/EP.a2021.0106
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 1T4GJ
UT WOS:000804688900011
PM 35119092
OA gold
DA 2025-06-11
ER

PT J
AU Scaini, G
   Quevedo, J
   Velligan, D
   Roberts, DL
   Raventos, H
   Walss-Bass, C
AF Scaini, Giselli
   Quevedo, Joao
   Velligan, Dawn
   Roberts, David L.
   Raventos, Henriette
   Walss-Bass, Consuelo
TI Second generation antipsychotic-induced mitochondrial alterations:
   Implications for increased risk of metabolic syndrome in patients with
   schizophrenia
SO EUROPEAN NEUROPSYCHOPHARMACOLOGY
LA English
DT Article
DE Metabolic syndrome; Schizophrenia; Antipsychotics; Mitochondrial
   dysfunction
ID ELECTRON-TRANSPORT CHAIN; HUMAN SKELETAL-MUSCLE; GENE-EXPRESSION;
   INSULIN-RESISTANCE; POSSIBLE MECHANISM; ENERGY-METABOLISM; OXIDATIVE
   STRESS; COMPLEX-I; 2A GENE; CELLS
AB Metabolic syndrome (MetS) is seen more frequently in persons with schizophrenia than in the general population, and these metabolic abnormalities are further aggravated by second generation antipsychotic (SGA) drugs. Although the underlying mechanisms responsible for the increased prevalence of MetS among patients under SGA treatment are not well understood, alterations in mitochondria function have been implicated. We performed a comprehensive evaluation of the role of mitochondrial dysfunction in the pathophysiology of drug-induced MetS in schizophrenia. We found a downregulation in genes encoding subunits of the electron transport chain complexes (ETC), enzyme activity, and mitochondrial dynamics in peripheral blood cells from patients at high-risk for MetS. Additionally, we evaluated several markers of energy metabolism in lymphoblastoid cell lines from patients with schizophrenia and controls following exposure to antipsychotics. We found that the high-risk drugs clozapine and olanzapine induced a general down-regulation of genes involved in the ETC, as well as decreased activities of the corresponding enzymes, ATP levels and a significant decrease in all the functional parameters of mitochondrial oxygen consumption in cells from patients and controls. We also observed that the medium-risk SGA quetiapine decreased oxygen consumption and respiratory control ratio in controls and patients. Additionally, clozapine and olanzapine induced a downregulation of Drp1 and Mfn2 both in terms of mRNA and protein levels. Together, these data suggest that an intrinsic defect in multiple components of oxidative metabolism may contribute to the increased prevalence of MetS in patients under treatment with SGAs known to cause risk for MetS. (C) 2018 Elsevier B.V. and ECNP. All rights reserved.
C1 [Scaini, Giselli; Quevedo, Joao; Walss-Bass, Consuelo] Univ Texas Hlth Sci Ctr Houston UTHlth, McGovern Med Sch, Dept Psychiat & Behav Sci, Translat Psychiat Program, Houston, TX USA.
   [Quevedo, Joao; Walss-Bass, Consuelo] Univ Texas Hlth Sci Ctr Houston UTHlth, McGovern Med Sch, Dept Psychiat & Behav Sci, Ctr Excellence Mood Disorders, Houston, TX USA.
   [Quevedo, Joao] Univ Southern Santa Catarina UNESC, Hlth Sci Unit, Grad Program Hlth Sci, Translat Psychiat Lab, Criciuma, SC, Brazil.
   [Velligan, Dawn; Roberts, David L.] Univ Texas Hlth Sci Ctr San Antonio, Dept Psychiat, San Antonio, TX 78229 USA.
   [Raventos, Henriette] Univ Costa Rica, Ctr Invest Biol Celular & Mol, San Jose, Costa Rica.
C3 University of Texas System; University of Texas Health Science Center
   Houston; Baylor College of Medicine; Baylor College Medical Hospital;
   University of Texas System; University of Texas Health Science Center
   Houston; Baylor College of Medicine; Baylor College Medical Hospital;
   Universidade do Sul de Santa Catarina; University of Texas System;
   University of Texas Health Science Center at San Antonio; Universidad
   Costa Rica
RP Walss-Bass, C (corresponding author), Univ Texas Hlth Sci Ctr Houston, Dept Psychiat & Behav Sci, 1941 East Rd,Ste 3110, Houston, TX 77054 USA.
EM Consuelo.WalssBass@uth.tmc.edu
RI Raventos, Henriette/GVS-4816-2022; Scaini, Giselli/AAX-4436-2020; de
   Quevedo, Joao Luciano/E-5491-2013; Walss-Bass, Consuelo/K-5702-2015;
   Scaini, Giselli/G-1378-2014
OI de Quevedo, Joao Luciano/0000-0003-3114-6611; Walss-Bass,
   Consuelo/0000-0003-2474-5448; Scaini, Giselli/0000-0002-9880-0887
FU University of Texas Health Science Center at San Antonio, Department of
   Psychiatry: Friends for Psychiatric Research; University of Texas Health
   Science Center at Houston, Department of Psychiatry and Behavioral
   Sciences
FX Funding for this study was provided in part by the University of Texas
   Health Science Center at San Antonio, Department of Psychiatry: Friends
   for Psychiatric Research, and University of Texas Health Science Center
   at Houston, Department of Psychiatry and Behavioral Sciences. The
   Department of Psychiatry: Friends for Psychiatric Research and
   Department of Psychiatry and Behavioral Sciences had no further role in
   study design; in the collection, analysis and interpretation of data; in
   the writing of the report; and in the decision to submit the paper for
   publication.
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NR 52
TC 38
Z9 41
U1 1
U2 21
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0924-977X
EI 1873-7862
J9 EUR NEUROPSYCHOPHARM
JI Eur. Neuropsychopharmacol.
PD MAR
PY 2018
VL 28
IS 3
BP 369
EP 380
DI 10.1016/j.euroneuro.2018.01.004
PG 12
WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA FX9KJ
UT WOS:000426417600004
PM 29449054
DA 2025-06-11
ER

PT J
AU Supriya, R
   Yu, AP
   Lee, PH
   Lai, CW
   Cheng, KK
   Yau, SY
   Chan, LW
   Yung, BY
   Siu, PM
AF Supriya, Rashmi
   Yu, Angus P.
   Lee, Paul H.
   Lai, Christopher W.
   Cheng, Kenneth K.
   Yau, Sonata Y.
   Chan, Lawrence W.
   Yung, Benjamin Y.
   Siu, Parco M.
TI Yoga training modulates adipokines in adults with high-normal blood
   pressure and metabolic syndrome
SO SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
LA English
DT Article
DE adipokine; high blood pressure; hypertension; metabolic syndrome;
   mind-body exercise
ID RANDOMIZED CONTROLLED-TRIAL; POSTMENOPAUSAL WOMEN; RISK-FACTORS;
   HYPERTENSION; EXERCISE; OBESITY; INTERVENTION; ADIPONECTIN; DISEASE;
   STRESS
AB Metabolic syndrome (MetS) is associated with diabetes mellitus and cardiovascular diseases. Our previous study indicated that people with MetS showed a decrease in waist circumference and a decreasing trend in blood pressure after 1-year yoga. This study investigated the effect of yoga on MetS people with high-normal blood pressure by exploring modulations in proinflammatory adipokines (leptin, chemerin, visfatin, and plasminogen activator inhibitor-1 or PAI-1) and an anti-inflammatory adipokine (adiponectin). A total of 97 Hong Kong Chinese individuals aged 57.6 +/- 9.1years with MetS and high-normal blood pressure were randomly assigned to control (n=45) and yoga groups (n=52). Participants in the control group were not given any intervention but were contacted monthly to monitor their health status. Participants in the yoga group underwent a yoga training program with three 1-hour yoga sessions weekly for 1year. The participants' sera were harvested and assessed for adipokines. Generalized estimating equation (GEE) was used to examine the interaction effect between 1-year time (pre vs post), and intervention (control vs yoga). GEE analyses revealed significant interaction effects between 1-year time and yoga intervention for the decreases in leptin and chemerin and the increase in adiponectin concentration in the sera examined. These results demonstrated that 1-year yoga training decreased proinflammatory adipokines and increased anti-inflammatory adipokine in adults with MetS and high-normal blood pressure. These findings support the beneficial role of yoga in managing MetS by favorably modulating adipokines.
C1 [Supriya, Rashmi; Lai, Christopher W.; Cheng, Kenneth K.; Chan, Lawrence W.; Yung, Benjamin Y.] Hong Kong Polytech Univ, Dept Hlth Technol & Informat, Fac Hlth & Social Sci, Kowloon, Hong Kong, Peoples R China.
   [Yu, Angus P.; Siu, Parco M.] Univ Hong Kong, Li Ka Shing Fac Med, Sch Publ Hlth, Pokfulam, Hong Kong, Peoples R China.
   [Lee, Paul H.] Hong Kong Polytech Univ, Sch Nursing, Fac Hlth & Social Sci, Kowloon, Hong Kong, Peoples R China.
   [Yau, Sonata Y.] Hong Kong Polytech Univ, Dept Rehabil Sci, Fac Hlth & Social Sci, Kowloon, Hong Kong, Peoples R China.
C3 Hong Kong Polytechnic University; University of Hong Kong; Hong Kong
   Polytechnic University; Hong Kong Polytechnic University
RP Siu, PM (corresponding author), Univ Hong Kong, Sch Publ Hlth, Pokfulam, Hong Kong, Peoples R China.
EM pmsiu@hku.hk
RI Cheng, Yip/C-4551-2009; Lai, Christopher Wai Keung/A-3852-2014; Lee,
   Paul/F-2549-2010
OI Yu, Angus, Pak Hung/0000-0002-7684-6198; Cheng, Kenneth King
   Yip/0000-0002-7274-0839; Supriya, Rashmi/0000-0003-2995-1910; Yau,
   Sonata Suk Yu/0000-0002-7425-6741; Lai, Christopher Wai
   Keung/0000-0002-8010-7232; Chan, Lawrence/0000-0001-6451-2273; Lee,
   Paul/0000-0002-5729-6450; Siu, Parco/0000-0002-3548-5058
FU Hong Kong Research Grants Council Hong Kong Ph.D. Fellowship Scheme
   [RTVX PF13-11753]; Hong Kong Polytechnic University Research Fund
   [1-ZE17]; University of Hong Kong Seed Fund for Basic Research
FX Hong Kong Research Grants Council Hong Kong Ph.D. Fellowship Scheme,
   Grant/Award Number: RTVX PF13-11753; Hong Kong Polytechnic University
   Research Fund, Grant/Award Number: 1-ZE17; The University of Hong Kong
   Seed Fund for Basic Research
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NR 34
TC 16
Z9 17
U1 0
U2 22
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0905-7188
EI 1600-0838
J9 SCAND J MED SCI SPOR
JI Scand. J. Med. Sci. Sports
PD MAR
PY 2018
VL 28
IS 3
BP 1130
EP 1138
DI 10.1111/sms.13029
PG 9
WC Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Sport Sciences
GA FY0VA
UT WOS:000426529300039
PM 29205515
DA 2025-06-11
ER

PT J
AU Aksu, O
   Aydin, B
   Doguç, DK
   Ilhan, I
   Ozturk, O
   Altuntas, A
   Demirkan, H
   Koroglu, BK
   Tamer, MN
AF Aksu, O.
   Aydin, B.
   Doguc, D. K.
   Ilhan, I.
   Ozturk, O.
   Altuntas, A.
   Demirkan, H.
   Koroglu, B. K.
   Tamer, M. N.
TI The evaluation of Nesfatin-1 levels in patients with OSAS associated
   with metabolic syndrome
SO JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
LA English
DT Article
DE Obstructive sleep apnea syndrome; Metabolic syndrome; Nesfatin-1
ID OBSTRUCTIVE SLEEP-APNEA
AB Purpose The association of obstructive sleep apnea syndrome (OSAS) and metabolic syndrome (MS) has been demonstrated in studies and in recent years; the effect of OSAS on insulin resistance independent of the level of obesity is being investigated. Nesfatin-1 is a newly defined 82 amino acid protein with a precursor molecule of NUCB2 (nucleobindin 2). Nesfatin-1 is not only essential in regulation of food ingestion but also important in regulation of some brain functions, autonomic regulation, stress, mental state, and paradoxical sleep. We aimed to evaluate the relationship between OSAS and MS and the MS dependent or independent effect of Nesfatin-1 on this relationship.
   Methods Patients admitted with clinical signs of OSAS are included. Patients are divided into three groups based on Apnea-Hypopnea Index (AHI) on Polysomnography (PSG) as mild, moderate, and severe OSAS. A total of 59 patients were included the control patients. Several OSAS parameters and laboratory findings which are and are not MS dependent are compared. Nesfatin-1 levels are evaluated in all OSAS patients with and without MS.
   Results There were significantly more males in all groups (p = 0.007). There was no significant difference between groups in terms of Nesfatin-1 levels. Nesfatin-1 levels were significantly lower in MS group compared to non-MS group (p = 0.021).
   Conclusion Nesfatin-1 which is known to play a role in the pathophysiology of insulin resistance can be a beneficial target in developing new therapeutic targets for treatment of patients with obesity without any toxic effects in the future.
C1 [Aksu, O.; Aydin, B.; Demirkan, H.; Koroglu, B. K.; Tamer, M. N.] Suleyman Demirel Univ, Sch Med, Div Endocrinol & Metab, Dept Internal Med,Fac Med, TR-3200 Isparta, Turkey.
   [Doguc, D. K.; Ilhan, I.] Suleyman Demirel Univ, Dept Biochem, Fac Med, TR-3200 Isparta, Turkey.
   [Ozturk, O.] Suleyman Demirel Univ, Dept Chest Dis, Fac Med, TR-3200 Isparta, Turkey.
   [Altuntas, A.] Suleyman Demirel Univ, Div Nephrol, Dept Internal Med, Fac Med, TR-3200 Isparta, Turkey.
C3 Suleyman Demirel University; Suleyman Demirel University; Suleyman
   Demirel University; Suleyman Demirel University
RP Aksu, O (corresponding author), Suleyman Demirel Univ, Sch Med, Div Endocrinol & Metab, Dept Internal Med,Fac Med, TR-3200 Isparta, Turkey.
EM droaksu@yahoo.com
RI Aksu, Oguzhan/MAH-8332-2025; ÖZTÜRK, ÖNDER/A-7651-2016; ilhan,
   ilter/AAA-4662-2021; Aydın, Betül/HDM-9418-2022
OI Ilhan, Ilter/0000-0003-3739-9580; Aksu, Oguzhan/0000-0003-4666-7129
CR Abaci A, 2013, PEDIATR DIABETES, V14, P189, DOI 10.1111/pedi.12009
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NR 26
TC 21
Z9 22
U1 0
U2 17
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0391-4097
EI 1720-8386
J9 J ENDOCRINOL INVEST
JI J. Endocrinol. Invest.
PD APR
PY 2015
VL 38
IS 4
BP 463
EP 469
DI 10.1007/s40618-014-0216-0
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA CE3CQ
UT WOS:000351702500011
PM 25432328
DA 2025-06-11
ER

PT J
AU Lee, J
   Choi, YS
   Jeong, YJ
   Lee, J
   Kim, JH
   Kim, SH
   Joe, SH
   Jeon, TH
AF Lee, Junyong
   Choi, Youn Seon
   Jeong, Young Jin
   Lee, Juneyoung
   Kim, Jung Hyun
   Kim, Su Hyun
   Joe, Sook-Haeng
   Jeon, Tae Hee
TI Poor-Quality Sleep Is Associated with Metabolic Syndrome in Korean
   Adults
SO TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE
LA English
DT Article
DE adiposity; insulin-resistance; Korea; metabolic syndrome; sleep
ID RISK-FACTOR; INSULIN-RESISTANCE; NATIONAL-HEALTH; DURATION; PREVALENCE;
   DISEASE; STRESS; INDEX; MEN
AB Sleep disorder and metabolic syndrome (MetS) are important health-related problems. Recently, sleep duration has decreased among Korean adults. In this study, we examined whether sleep quality is associated with MetS by analyzing 301 subjects, aged 20 years or over, without acute and severe illness who visited three primary care clinics. Sleep duration, sleep quality and the risk of sleep-related breathing disorder (SRBD) were assessed with a standardized sleeping-estimating instrument. MetS was defined according to the modified diagnostic criteria of the National Cholesterol Education Program Adult Treatment Panel-III using the Korean abdominal obesity definition. In the multiple logistic regression analysis, compared with the 7-hour sleep group, the adjusted odds ratios (ORs) of the <= 5- and >= 9-hour sleep groups for MetS were 4.89 and 5.98, respectively. Compared with the good-sleep quality and low-SRBD risk groups, the adjusted ORs of the poor-quality sleep and high-SRBD risk groups were 3.83 and 1.92, respectively (p < 0.05). In the <= 5- and >= 9-hour sleep groups, the prevalence of elevated triglyceride and high HOMA-IR was higher (p = 0.069). In the poor-quality sleep group, the prevalence of abdominal obesity, elevated triglyceride, low HDL cholesterol, high fasting insulin and high HOMA-IR were higher. In the high-SRBD risk group, the prevalence of abdominal obesity, obesity and elevated triglyceride were higher (p < 0.05). Overall, the <= 5- or >= 9-hour sleep duration, poor-quality sleep and high-SRBD risk are related with the high prevalence of MetS, perhaps through elevated insulin-resistance resulting from adiposity.
C1 [Lee, Junyong; Jeong, Young Jin; Jeon, Tae Hee] Vet Hlth Serv VHS Med Ctr, Dept Family Med, Seoul, South Korea.
   [Choi, Youn Seon; Kim, Su Hyun] Korea Univ, Guro Hosp, Coll Med, Dept Family Med, Seoul 152703, South Korea.
   [Lee, Juneyoung] Korea Univ, Coll Med, Dept Biostat, Seoul 152703, South Korea.
   [Kim, Jung Hyun] Hana Gen Hosp, Dept Family Med, Cheongju, Chungcheongbuk, South Korea.
   [Joe, Sook-Haeng] Korea Univ, Guro Hosp, Coll Med, Dept Psychiat, Seoul 152703, South Korea.
C3 Korea University; Korea University Medicine (KU Medicine); Korea
   University; Korea University Medicine (KU Medicine); Korea University;
   Korea University Medicine (KU Medicine)
RP Choi, YS (corresponding author), Korea Univ, Guro Hosp, Coll Med, Dept Family Med, 97 Guro Dong Gil, Seoul 152703, South Korea.
EM younseon@korea.ac.kr
RI Lee, Jeong-Hoon/Q-1055-2018; Kim, Sin Gon/KQU-7757-2024
OI Lee, Juneyoung/0000-0001-8073-9304; Choi, Youn Seon/0000-0003-2406-5848;
   Lee, Junyong/0000-0001-9467-9277
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NR 40
TC 24
Z9 26
U1 0
U2 6
PU TOHOKU UNIV MEDICAL PRESS
PI SENDAI
PA 2-1, SEIRYO-MACHI, AOBA-KU, SENDAI, MIYAGI 980-8575, JAPAN
SN 0040-8727
EI 1349-3329
J9 TOHOKU J EXP MED
JI Tohoku J. Exp. Med.
PD DEC
PY 2013
VL 231
IS 4
BP 281
EP 291
DI 10.1620/tjem.231.281
PG 11
WC Medicine, General & Internal; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Research & Experimental Medicine
GA 292FB
UT WOS:000329886500006
PM 24305464
OA Bronze
DA 2025-06-11
ER

PT J
AU Zong, G
   Demark-Wahnefried, W
   Wu, HY
   Lin, X
AF Zong, Geng
   Demark-Wahnefried, Wendy
   Wu, Hongyu
   Lin, Xu
TI Effects of flaxseed supplementation on erythrocyte fatty acids and
   multiple cardiometabolic biomarkers among Chinese with risk factors of
   metabolic syndrome
SO EUROPEAN JOURNAL OF NUTRITION
LA English
DT Article
DE Flaxseed; PUFA; Cytokines; Metabolic syndrome
ID ALPHA-LINOLENIC-ACID; CARDIOVASCULAR-DISEASE; DOUBLE-BLIND; MARKERS
AB We investigated effects of ground whole flaxseed supplementation on erythrocyte polyunsaturated fatty acids (PUFAs) and serum biomarkers of inflammation, endothelial dysfunction, oxidative stress, and thrombosis in Chinese with risk factors of metabolic syndrome (MetS).
   This study was a secondary analysis of a 12-week, randomized, parallel-group trial in participants screened for MetS. The analysis included only those with 2 or more components of MetS before receiving either lifestyle counseling (LC, n = 90) or LC + 30 g/day flaxseed supplementation (LCF, n = 83).
   Compared to the LC group, those in the LCF group experienced significant increases in total erythrocyte n-3 PUFAs, alpha-linolenic acid, eicosapentenoic acid, and docosapentenoic acid (all P < 0.001), while total n-6 PUFAs (P < 0.05) and n-6/n-3 ratio decreased (P < 0.001). Arachidonic acid increased significantly in the LC group (P < 0.001), and serum high-sensitivity C-reactive protein, interleukin-18, soluble intracellular adhesion molecular-1, E-selectin, and plasminogen activator inhibitor-1 declined significantly in both groups (all P < 0.05), but no between-group differences were observed. There was no significant change in serum interleukin-6, tumor necrosis factor-alpha, soluble vascular adhesion molecular-1, monocyte chemoattractant protein-1, and oxidized low-density lipoprotein in either group.
   These data suggest that flaxseed supplementation increases erythrocyte n-3 PUFAs, decreases n-6 PUFAs and n-6/n-3 ratio in participants with risk factors of MetS, but has no additional benefits beyond the lifestyle consulting for the multiple biomarkers tested in the current study.
C1 [Zong, Geng; Lin, Xu] Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Key Lab Nutr & Metab, Shanghai 200031, Peoples R China.
   [Zong, Geng; Lin, Xu] Chinese Acad Sci, Grad Sch, Shanghai 200031, Peoples R China.
   [Demark-Wahnefried, Wendy] Univ Alabama Birmingham, Dept Nutr Sci, Birmingham, AL 35294 USA.
   [Wu, Hongyu] Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA.
C3 Chinese Academy of Sciences; Chinese Academy of Sciences; University of
   Alabama System; University of Alabama Birmingham; Harvard University;
   Harvard T.H. Chan School of Public Health
RP Lin, X (corresponding author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Key Lab Nutr & Metab, 294 Tai Yuan Rd, Shanghai 200031, Peoples R China.
EM xlin@sibs.ac.cn
RI lin, xu/KOC-3517-2024; Zong, Geng/ABG-6946-2021
OI Demark-Wahnefried, Wendy/0000-0001-5241-932X
FU National Natural Science Foundation of China [30930081, 81021002];
   Ministry of Science and Technology of China [2011CB504002]; Chinese
   Academy of Sciences [KSCX2-EW-R-10]
FX This study was supported by the National Natural Science Foundation of
   China (30930081 and 81021002), the Ministry of Science and Technology of
   China (2011CB504002) and the Chinese Academy of Sciences
   (KSCX2-EW-R-10). The authors' responsibilities were as follows: H. W.
   and X. L. were involved in the study design; G.Z. and H. W. were in
   charge of participant management; G.Z., H. W, and X. L. took part in the
   data collection; G.Z completed the data analysis and drafted the initial
   manuscript, with help from H. W. W. D-W and X. L for interpretation of
   the findings. All authors were responsible for critical revisions and
   final approval of the manuscript. All authors declared no conflict of
   interest.
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NR 15
TC 16
Z9 16
U1 0
U2 13
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1436-6207
EI 1436-6215
J9 EUR J NUTR
JI Eur. J. Nutr.
PD AUG
PY 2013
VL 52
IS 5
BP 1547
EP 1551
DI 10.1007/s00394-012-0461-y
PG 5
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 185YQ
UT WOS:000322008000015
PM 23179200
DA 2025-06-11
ER

PT J
AU Libby, P
   Plutzky, J
AF Libby, Peter
   Plutzky, Jorge
TI Inflammation in diabetes mellitus:: Role of peroxisome
   proliferator-activated receptor-α and peroxisome proliferator-activated
   receptor-γ agonists
SO AMERICAN JOURNAL OF CARDIOLOGY
LA English
DT Review
ID CORONARY-HEART-DISEASE; TISSUE FACTOR EXPRESSION; APOLIPOPROTEIN-A-I;
   NF-KAPPA-B; PPAR-ALPHA; CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME;
   GENE-EXPRESSION; COMBINED HYPERLIPIDEMIA; ROSIGLITAZONE TREATMENT
AB Patients with type 2 diabetes mellitus and/or the metabolic syndrome have considerable cardiovascular risk. Treatment with 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) and with antihypertensive and some antihyperglycemic agents reduces this risk, but residual macrovascular morbidity and mortality persist, even in patients assigned to intensive multifactorial intervention programs. Therapeutic strategies that target inflammation and lipid abnormalities not well addressed by statins may offer additional opportunities for improving the prognosis of these patients. Inflammation, a key mechanism of atherogenesis, appears to have particular relevance to diabetic vascular complications, as well as in the development of diabetes itself. Oxidative stress and hyperglycemia also figure among the pathogenic factors that promote cardiovascular complications in patients with the metabolic syndrome and/or diabetes and may augment the ongoing inflammation. Peroxisome proliferator-activated receptor (PPAR)-alpha and PPAR-gamma, members of the nuclear receptor family, form ligand-activated transcription factors that regulate key important metabolic pathways. PPARs have become therapeutic targets through the use of the fibrate class of antidyslipidemic drugs (PPAR-alpha) and the insulin-sensitizing thiazolidinediones (PPAR-gamma). The activation of these PPARs may also suppress inflammation and atherosclerosis. Recent clinical trials (Fenofibrate Intervention and Event Lowering in Diabetes [FIELD], Prospective Pioglitazone Clinical Trial in Macrovascular Events [PROactive]) have considered the impact of these PPAR agonists on cardiovascular disease, with mixed effects that require careful analysis, especially given ongoing trials and additional PPAR agonists in development. (c) 2007 Elsevier Inc. All rights reserved.
C1 Harvard Univ, Brigham & Womens Hosp, Sch Med, Div Cardiovasc Med,Dept Med, Boston, MA 02115 USA.
C3 Harvard University; Harvard University Medical Affiliates; Brigham &
   Women's Hospital; Harvard Medical School
RP Libby, P (corresponding author), Harvard Univ, Brigham & Womens Hosp, Sch Med, Div Cardiovasc Med,Dept Med, 77 Ave Louis Pasteur, Boston, MA 02115 USA.
EM plibby@rics.bwh.harvard.edu
RI Libby, Peter/AAY-6404-2021; Plutzky, Jorge/V-3410-2019
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NR 149
TC 102
Z9 115
U1 1
U2 7
PU EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
PI BRIDGEWATER
PA 685 ROUTE 202-206 STE 3, BRIDGEWATER, NJ 08807 USA
SN 0002-9149
EI 1879-1913
J9 AM J CARDIOL
JI Am. J. Cardiol.
PD FEB 19
PY 2007
VL 99
IS 4A
SU S
BP 27B
EP 40B
DI 10.1016/j.amjcard.2006.11.004
PG 14
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 143FR
UT WOS:000244705900005
PM 17307056
DA 2025-06-11
ER

PT J
AU Xu, YJ
   Sutanto, CN
   Xia, XJ
   Toh, DWK
   Gan, AX
   Deng, QY
   Ling, LH
   Khoo, CM
   Foo, RSY
   Kim, JE
AF Xu, Yujing
   Sutanto, Clarinda Nataria
   Xia, Xuejuan
   Toh, Darel Wee Kiat
   Gan, Alicia Xinli
   Deng, Qiyun
   Ling, Lieng Hsi
   Khoo, Chin Meng
   Foo, Roger Sik-Yin
   Kim, Jung Eun
TI Consumption of plant sterols-enriched soy milk with a healthy dietary
   pattern diet lowers blood pressure in adults with metabolic syndrome: A
   randomized controlled trial
SO NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
LA English
DT Article
DE Cardiovascular disease; Endothelial function; Plant sterols; Healthy
   dietary pattern; Blood pressure; Metabolic syndrome
ID ENDOTHELIAL PROGENITOR CELLS; NITRIC-OXIDE; CIRCADIAN PATTERN; OXIDATIVE
   STRESS; SMOOTH-MUSCLE; CHOLESTEROL; MARKERS; INFLAMMATION; COMPONENTS;
   OBESITY
AB Background & aims: Plant sterols (PS) have been shown to lower blood lipid-lipoproteins concentrations and may serve as a potential functional ingredient for cardiovascular disease (CVD) risk management. However, there are limited studies examining this effect in individuals with metabolic syndrome (MetS). The aim of this study was to evaluate the effects of PS-enriched food consumption as part of a healthy dietary pattern (HDP) on blood pressure and endothelial function in Singaporean adults with MetS. Methods and results: This was a 12-week, crossover, randomized controlled trial with a 4-week washout period. Thirteen subjects were instructed to consume an HDP diet either with normal soy milk (control group) or with PS (2 g/day)-enriched soy milk (PS group) for 4 weeks. Blood lipid-lipoproteins and glucose concentrations, blood pressure, and endothelial function-related indicators (flow-mediated dilation, total plasma nitrate/nitrite and endothelin-1, circulating endothelial progenitor cells) were assessed before and after the intervention. Systolic blood pressure [mean change, PS group: -4.0 f 3.7 mmHg; control group: 5.9 f 2.5 mmHg (PInteraction = 0.01)] and long-term CVD risk [mean change, PS group: -0.2 f 1.0 %; control group: 2.7 f 1.3 % (PInteraction = 0.03)] decreased following PS consumption. No changes were observed in the other endothelial function-related outcomes. Conclusions: Consumption of PS-enriched food with an HDP diet may lower blood pressure and long-term CVD risk in adults with MetS. Clinical trial registration: NCT03723330, https://clinicaltrials.gov/.
C1 [Xu, Yujing; Sutanto, Clarinda Nataria; Xia, Xuejuan; Toh, Darel Wee Kiat; Gan, Alicia Xinli; Deng, Qiyun; Kim, Jung Eun] Natl Univ Singapore, Fac Sci, Dept Food Sci & Technol, Singapore, Singapore.
   [Xia, Xuejuan] Univ Shanghai Sci & Technol, Sch Hlth Sci & Engn, Shanghai, Peoples R China.
   [Ling, Lieng Hsi] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Med, Singapore, Singapore.
   [Ling, Lieng Hsi] Natl Univ Heart Ctr, Dept Cardiol, Singapore, Singapore.
   [Khoo, Chin Meng] Natl Univ Singapore Hosp, Univ Med Cluster, Div Endocrinol, Singapore, Singapore.
   [Foo, Roger Sik-Yin] Natl Univ Singapore, Cardiovasc Res Inst, Yong Loo Lin Sch Med, Singapore, Singapore.
   [Foo, Roger Sik-Yin] Genome Inst Singapore, Singapore, Singapore.
C3 National University of Singapore; University of Shanghai for Science &
   Technology; National University of Singapore; National University of
   Singapore; National University of Singapore; National University of
   Singapore; Agency for Science Technology & Research (A*STAR); A*STAR -
   Genome Institute of Singapore (GIS)
RP Kim, JE (corresponding author), Natl Univ Singapore, Fac Sci, Dept Food Sci & Technol, Singapore, Singapore.
EM fstkje@nus.edu.sg
RI xu, yujing/GYJ-2312-2022; Khoo, Chin Meng/AAD-8790-2022; Kim, Jung
   Eun/LWI-5710-2024; Kim, Jung Eun/O-9332-2017
OI Khoo, Chin Meng/0000-0003-1601-2391; Xu, Yujing/0009-0009-3424-5974;
   Kim, Jung Eun/0000-0002-3912-9042; Toh, Darel Wee
   Kiat/0000-0003-1608-0669; Ling, Lieng H./0000-0001-6063-8530
FU BASF Singapore
FX This study is supported by BASF Singapore. Representatives from the BASF
   Singapore were not involved in the design implementation, analysis, or
   interpretation of data from this investigator-initiated study.
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NR 73
TC 0
Z9 0
U1 3
U2 5
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 0939-4753
EI 1590-3729
J9 NUTR METAB CARDIOVAS
JI Nutr. Metab. Carbiovasc. Dis.
PD JAN
PY 2025
VL 35
IS 1
AR 103773
DI 10.1016/j.numecd.2024.10.011
EA NOV 2024
PG 9
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism; Nutrition
   & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism;
   Nutrition & Dietetics
GA M9G4B
UT WOS:001360539700001
PM 39561689
DA 2025-06-11
ER

PT J
AU Bagetta, D
   Maruca, A
   Lupia, A
   Mesiti, F
   Catalano, R
   Romeo, I
   Moraca, F
   Ambrosio, FA
   Costa, G
   Artese, A
   Ortuso, F
   Alcaro, S
   Rocca, R
AF Bagetta, Donatella
   Maruca, Annalisa
   Lupia, Antonio
   Mesiti, Francesco
   Catalano, Raffaella
   Romeo, Isabella
   Moraca, Federica
   Ambrosio, Francesca Alessandra
   Costa, Giosue
   Artese, Anna
   Ortuso, Francesco
   Alcaro, Stefano
   Rocca, Roberta
TI Mediterranean products as promising source of multi-target agents in the
   treatment of metabolic syndrome
SO EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
LA English
DT Article
DE Metabolic syndrome (MetS); Mediterranean diet (MedDiet); Multi-target;
   Polypharmacology; Prevention; Anti-oxidant; Anti-inflammatory;
   Polyphenols
ID DIET-INDUCED OBESITY; VIRGIN OLIVE OIL; CROCUS-SATIVUS L.; INHIBIT
   ADIPOCYTE DIFFERENTIATION; PERFORMANCE LIQUID-CHROMATOGRAPHY; ROSEMARY
   ROSMARINUS-OFFICINALIS; CARDIOVASCULAR-DISEASE RISK; ACTIVATED
   PROTEIN-KINASE; CITRUS-BERGAMIA RISSO; HMG-COA REDUCTASE
AB Alteration of nutritional habits play an essential role on the risk of developing Metabolic Syndrome (MetS). Several epidemiological studies have shown that assuming diets rich of foods included in the Mediterranean diet (MetDiet) pattern like, such as olive oil, nuts, fruit, fiber, vegetables, wine and grain cereals has protective effects on the different risk factors characterizing the MetS. The beneficial effects of the MetDiet in the MetS are mainly due to the antioxidant and anti-inflammatory properties of the most abundant phytochemical components of such foods as polyphenols like resveratrol and oleuropein, allyl sulfides, ellagic acid, mono- and poly-unsaturated fatty acids (MUFA and PUFA), tocopherols and flavonoids like quercetin, which have shown positive results in the prevention of cardiovascular diseases (CVDs), with related risk factors, like hypertension, hypercholesterolemia and obesity. In this review, we highlighted the multi-target activities of the bioactive components contained in some foods typical of the Mediterranean area like olive oil, onion, liquorice, rosemary, oregano, hazelnut, pistachio, "Melannurca" apple, red wine, hot pepper, Citrus sp. fruits, saffron and garlic, with particular focus on their impact on health outcomes in relation to MetS main key factors, such as insulin resistance (IR) and type 2 diabetes mellitus (T2DM), endothelial dysfunctions, inflammatory response, oxidative stress and dyslipidaemic and hypercholesterolemic effects. (C) 2019 Elsevier Masson SAS. All rights reserved.
C1 [Bagetta, Donatella; Maruca, Annalisa; Lupia, Antonio; Mesiti, Francesco; Catalano, Raffaella; Ambrosio, Francesca Alessandra; Costa, Giosue; Artese, Anna; Ortuso, Francesco; Alcaro, Stefano] Magna Graecia Univ Catanzaro, Dipartimento Sci Salute, Campus Salvatore Venuta,Viale Europa, I-88100 Catanzaro, Italy.
   [Bagetta, Donatella; Maruca, Annalisa; Lupia, Antonio; Mesiti, Francesco; Catalano, Raffaella; Romeo, Isabella; Moraca, Federica; Costa, Giosue; Artese, Anna; Ortuso, Francesco; Alcaro, Stefano; Rocca, Roberta] Magna Graecia Univ Catanzaro, Net4Science Srl, Campus Salvatore Venuta,Viale Europa, I-88100 Catanzaro, Italy.
   [Romeo, Isabella] Univ Calabria, Dept Chem & Chem Technol, Via Pietro Bucci, I-87036 Arcavacata Di Rende, Italy.
   [Moraca, Federica] Univ Naples Federico II, Dept Pharm, Via D Montesano 49, I-80131 Naples, Italy.
   [Rocca, Roberta] Magna Graecia Univ Catanzaro, Dept Expt & Clin Med, Campus Salvatore Venuta,Viale Europa, I-88100 Catanzaro, Italy.
C3 Magna Graecia University of Catanzaro; Magna Graecia University of
   Catanzaro; University of Calabria; University of Naples Federico II;
   Magna Graecia University of Catanzaro
RP Ambrosio, FA (corresponding author), Magna Graecia Univ Catanzaro, Dipartimento Sci Salute, Campus Salvatore Venuta,Viale Europa, I-88100 Catanzaro, Italy.; Moraca, F (corresponding author), Magna Graecia Univ Catanzaro, Net4Science Srl, Campus Salvatore Venuta,Viale Europa, I-88100 Catanzaro, Italy.
EM federica.moraca@unina.it; ambrosio@unicz.it
RI Rocca, Roberta/L-7431-2016; Catalano, Raffaella/HDO-3350-2022; Romeo,
   Isabella/ACS-6478-2022; Lupia, Antonio/CAH-2362-2022; Costa,
   Giosue/K-8461-2016
OI ALCARO, Stefano/0000-0002-0437-358X; Maruca,
   Annalisa/0000-0002-6537-552X; Catalano, Raffaella/0000-0003-3936-3573;
   Mesiti, Francesco/0000-0002-9968-4996; Costa,
   Giosue/0000-0003-0947-9479; Lupia, Antonio/0000-0003-0870-2376
FU  [201744BN5T]
FX The authors acknowledge the PRIN 2017 research project "Novel anticancer
   agents endowed with multi-targeting mechanism of action" [Project n.
   201744BN5T].
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NR 286
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Z9 70
U1 2
U2 44
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0223-5234
EI 1768-3254
J9 EUR J MED CHEM
JI Eur. J. Med. Chem.
PD JAN 15
PY 2020
VL 186
AR 111903
DI 10.1016/j.ejmech.2019.111903
PG 30
WC Chemistry, Medicinal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA KG0FJ
UT WOS:000509616800042
PM 31787360
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Dasuri, K
   Zhang, L
   Kim, SOKF
   Bruce-Keller, AJ
   Keller, JN
AF Dasuri, Kalavathi
   Zhang, Le
   Kim, Sun O. K. Fernandez
   Bruce-Keller, Annadora J.
   Keller, Jeffrey N.
TI Dietary and donepezil modulation of mTOR signaling and neuroinflammation
   in the brain
SO BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
LA English
DT Article
DE Brain; Aging; High fat diet; Obesity; Neurodegenerative disorders; mTOR
   pathway; Donepezil; Neuroinflammation
ID HIGH-FAT-DIET; INDUCED INSULIN-RESISTANCE; TAUOPATHY MOUSE MODEL;
   ALZHEIMERS-DISEASE; MAMMALIAN TARGET; ADIPOSE-TISSUE; GLUTAMATE
   NEUROTOXICITY; COGNITIVE IMPAIRMENT; METABOLIC SYNDROME; OXIDATIVE
   STRESS
AB Recent clinical and laboratory evidences suggest that high fat diet (HFD) induced obesity and its associated metabolic syndrome conditions promotes neuropathology in aging and age-related neurological disorders. However, the effects of high fat diet on brain pathology are poorly understood, and the effective strategies to overcome these effects remain elusive. In the current study, we examined the effects of HFD on brain pathology and further evaluated whether donepezil, an AChE inhibitor with neuroprotective functions, could suppress the ongoing HFD induced pathological changes in the brain.
   Our data demonstrates that HFD induced obesity results in increased neuroinflammation and increased AChE activity in the brain when compared with the mice fed on low fat diet (LFD). HFD administration to mice activated mTOR pathway resulting in increased phosphorylation of mTORser2448, AKTthr3 8 and S6K proteins involved in the signaling. Interestingly, donepezil administration with HFD suppressed HFD induced increases in AChE activity, and partially reversed HFD effects on microglial reactivity and the levels of mTOR signaling proteins in the brain when compared to the mice on LFD alone. However, gross levels of synaptic proteins were not altered in the brain tissues of mice fed either diet with or without donepezil. In conclusion, these results present a new insight into the detrimental effects of HFD on brain via microglial activation and involvement of mTOR pathway, and further demonstrates the possible therapeutic role for donepezil in ameliorating the early effects of HFD that could help preserve the brain function in metabolic syndrome conditions. (C) 2015 Elsevier B.V. All rights reserved.
C1 [Dasuri, Kalavathi; Zhang, Le; Kim, Sun O. K. Fernandez; Bruce-Keller, Annadora J.; Keller, Jeffrey N.] LSU Syst, Pennington Biomed Res Ctr, Baton Rouge, LA 70810 USA.
   [Dasuri, Kalavathi] Tufts Univ, USDA, Human Nutr Res Ctr Aging, Boston, MA 02111 USA.
   [Zhang, Le] Huazhong Univ Sci & Technol, Tongji Hosp, Dept Geriatr, Inst Aging, Wuhan 430074, Peoples R China.
C3 Louisiana State University System; Louisiana State University;
   Pennington Biomedical Research Center; Tufts University; United States
   Department of Agriculture (USDA); Huazhong University of Science &
   Technology
RP Dasuri, K (corresponding author), LSU Syst, Pennington Biomed Res Ctr, Baton Rouge, LA 70810 USA.; Dasuri, K (corresponding author), Tufts Univ, USDA, Human Nutr Res Ctr Aging, Boston, MA 02111 USA.
EM Kalavathidasuri@gmail.com
RI DASURI, KALAVATHI/E-7381-2012; Bruce-Keller, Annadora/N-1954-2017;
   Keller, Jeffrey/N-1975-2017
OI keller, jeffrey/0000-0002-9892-7423
FU COBRE from the National Institutes of Health [NIH 2P20-RR021945]; NORC
   from the National Institutes of Health [NIH 2P30-DK072476]; Pennington
   Animal Metabolism and Behavior Core; NIH; Hibernia National Bank/Edward
   G Schleider Chair
FX This work used the facilities of the Cell Biology and Bioimaging Core
   which are supported in part by COBRE (NIH 2P20-RR021945) and NORC (NIH
   2P30-DK072476) center grants from the National Institutes of Health, the
   Pennington Animal Metabolism and Behavior Core. The work was supported
   by funds from the NIH and Hibernia National Bank/Edward G Schleider
   Chair to JNK.
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Z9 24
U1 0
U2 8
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0925-4439
EI 0006-3002
J9 BBA-MOL BASIS DIS
JI Biochim. Biophys. Acta-Mol. Basis Dis.
PD FEB
PY 2016
VL 1862
IS 2
BP 274
EP 283
DI 10.1016/j.bbadis.2015.11.002
PG 10
WC Biochemistry & Molecular Biology; Biophysics; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Cell Biology
GA DN9SH
UT WOS:000377420500014
PM 26554604
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Mahli, A
   Hellerbrand, C
AF Mahli, Abdo
   Hellerbrand, Claus
TI Alcohol and Obesity: A Dangerous Association for Fatty Liver Disease
SO DIGESTIVE DISEASES
LA English
DT Article
DE Alcoholic liver disease; Nonalcoholic fatty liver disease; Metabolic
   syndrome; Obesity; Synergism
ID ENDOPLASMIC-RETICULUM STRESS; HEPATIC STELLATE CELLS; BODY-MASS INDEX;
   HEPATOCELLULAR-CARCINOMA; LIPID-ACCUMULATION; RISK-FACTORS; DECREASED
   PREVALENCE; NATURAL-HISTORY; CONSUMPTION; ETHANOL
AB Alcoholic liver disease (ALD) and nonalcoholic fatty liver disease (NAFLD) are the most frequent chronic liver disorders, and their advanced forms - alcoholic steatohepatitis and nonalcoholic steatohepatitis - are the most frequent conditions leading to liver cirrhosis and hepatocellular carcinoma worldwide. NAFLD is considered as the hepatic manifestation of the metabolic syndrome. With the pandemic rise of obesity, the incidence of NAFLD is also further increasing, and considering the life style in modern societies, there is a significant overlap of (risk factors causing) NAFLD and (alcohol consumption predisposing for) ALD at least in Western countries. Epidemiological studies propose a causative link between chronic alcohol consumption and progressive liver disease in obese individuals. Furthermore, experimental studies indicate combined pathological effects of alcohol and obesity or fatty acid levels, respectively, on hepatocellular lipid accumulation and injury as well as hepatic inflammation, fibrosis and cancerogenesis. Notably, these combined pathological effects are in part additive but partly even synergistic. And importantly, alcohol does already exhibit synergistic pathological effects with obesity at moderate doses. This indicates significant differences in the dose threshold for hepatotoxic alcohol effects in lean and obese subjects and herewith also has important implications for recommendations for 'safe' alcohol consumption. The purpose of this brief review is to update the knowledge on the combined effects of alcohol and obesity on the development and progression of liver disease. Undoubtedly, alcohol and the metabolic syndrome appear as a dangerous mix, and there are important interactive effects of either condition with regard to crucial triggers of liver injury. (C) 2016 S. Karger AG, Basel
C1 [Mahli, Abdo; Hellerbrand, Claus] Univ Hosp Regensburg, Dept Internal Med 1, DE-3053 Regensburg, Germany.
C3 University of Regensburg
RP Hellerbrand, C (corresponding author), Univ Hosp Regensburg, Dept Internal Med 1, DE-3053 Regensburg, Germany.
EM claus.hellerbrand@ukr.de
RI Mahli, Abdo/AAD-4744-2019
OI Mahli, Abdo/0000-0002-8333-7551
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NR 79
TC 49
Z9 51
U1 1
U2 13
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0257-2753
EI 1421-9875
J9 DIGEST DIS
JI Dig. Dis.
PY 2016
VL 34
SU 1
BP 32
EP 39
DI 10.1159/000447279
PG 8
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA DU0HA
UT WOS:000381882000006
PM 27548267
OA Green Published
DA 2025-06-11
ER

PT J
AU Siervo, M
   Harrison, SL
   Jagger, C
   Robinson, L
   Stephan, BCM
AF Siervo, Mario
   Harrison, Stephanie L.
   Jagger, Carol
   Robinson, Louise
   Stephan, Blossom C. M.
TI Metabolic Syndrome and Longitudinal Changes in Cognitive Function: A
   Systematic Review and Meta-Analysis
SO JOURNAL OF ALZHEIMERS DISEASE
LA English
DT Article
DE Aging; cognition; cohort studies; metabolic syndrome; risk prediction;
   systematic review
ID VASCULAR RISK-FACTORS; ALZHEIMERS-DISEASE; INSULIN-RESISTANCE;
   NEUROPSYCHOLOGICAL TESTS; DIABETES-MELLITUS; OXIDATIVE STRESS; DECLINE;
   DEMENTIA; POPULATION; IMPAIRMENT
AB Background: Metabolic syndrome (MetS) is associated with an increased risk of coronary heart diseases and stroke. Results on the association of MetS with dementia and cognitive decline have been inconsistent.
   Objective: The aim of this study was to examine the association between MetS and longitudinal changes in cognitive function.
   Methods: Medline, EMBASE, and Scopus databases were searched from inception to June 2013. Longitudinal cohort studies that reported on the association between MetS and change in cognitive function (over two or more time points), were included.
   Results: Random-effects models were used to assess the pooled effect sizes of longitudinal changes in cognitive function associated with MetS. Thirteen studies were included. The total sample size was 19,522 subjects. Followup duration ranged from 1 to 16 years. In the total sample, a small association of MetS with cognitive decline was observed (SDM 0.06, 95% CI: -0.001, 0.12; p = 0.05). When age-stratified, a marginal significant association between MetS and cognitive decline was observed in the younger old group (<= 70 years; SDM=0.09, 95% CI: -0.003, 0.19; p = 0.05) but not in the older group (> 70 years; SDM=0.03, 95% CI: -0.05, 0.11; p = 0.48). The meta-regression showed that duration of follow up was not associated with changes in cognitive estimates (beta = 0.005; p = 0.30).
   Conclusions: Age appears to modify the association between MetS and cognitive decline. These results emphasize the importance of age-stratified risk prediction models of dementia in subjects with chronic metabolic disorders.
C1 [Siervo, Mario; Harrison, Stephanie L.; Jagger, Carol] Newcastle Univ, Inst Ageing & Hlth, Newcastle Upon Tyne NE4 5PL, Tyne & Wear, England.
   [Robinson, Louise; Stephan, Blossom C. M.] Newcastle Univ, Inst Hlth & Soc, Newcastle Upon Tyne NE4 5PL, Tyne & Wear, England.
C3 Newcastle University - UK; Newcastle University - UK
RP Siervo, M (corresponding author), Newcastle Univ, Inst Ageing & Hlth, Campus Ageing & Vital, Newcastle Upon Tyne NE4 5PL, Tyne & Wear, England.
EM mario.siervo@newcastle.ac.uk
RI Siervo, Mario/AAB-9302-2019; Stephan, Blossom/A-1560-2009
OI Robinson, Louise/0000-0003-0209-2503; Harrison,
   Stephanie/0000-0002-8846-0946; Jagger, Carol/0000-0002-6377-9926;
   Siervo, Mario/0000-0001-5515-0944
FU MRC [MR/J50001X/1, G0500997] Funding Source: UKRI
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NR 65
TC 93
Z9 104
U1 0
U2 18
PU IOS PRESS
PI AMSTERDAM
PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS
SN 1387-2877
EI 1875-8908
J9 J ALZHEIMERS DIS
JI J. Alzheimers Dis.
PY 2014
VL 41
IS 1
BP 151
EP 161
DI 10.3233/JAD-132279
PG 11
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology
GA AI5PH
UT WOS:000336921000011
PM 24577475
DA 2025-06-11
ER

PT J
AU Perez-Martinez, P
   Perez-Jimenez, F
   Lopez-Miranda, J
AF Perez-Martinez, Pablo
   Perez-Jimenez, Francisco
   Lopez-Miranda, Jose
TI n-3 PUFA and lipotoxicity
SO BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
LA English
DT Review
DE n-3 PUFA; Lipotoxicity; Triglycerides; Metabolic syndrome; Lipid
   accumulation; Lipoapoptosis
ID POLYUNSATURATED FATTY-ACIDS; INSULIN-RESISTANCE; BETA-CELL;
   CARDIOVASCULAR-DISEASE; NONFASTING TRIGLYCERIDES; ENDOTHELIAL FUNCTION;
   METABOLIC SYNDROME; HEPATIC STEATOSIS; OXIDATIVE STRESS; TRANSGENIC MICE
AB Excess lipid accumulation in nonadipose tissues may occur in the setting of high levels of plasma free fatty acids or triglycerides (TGs) in a process called "lipotoxicity". Evidence from human studies and animal models suggests that lipid accumulation in the heart, skeletal muscle, pancreas, and liver play an important role in the pathogenesis of heart failure, obesity, metabolic syndrome, and type 2 diabetes mellitus (T2DM). During the past few years, several studies have shown that n-3 polyunsaturated fatty acids (PUFA) have potentially cardioprotective effects, especially in high-risk patients with dyslipidemia, and might therefore be expected to be of benefit in T2DM. Moreover, new information has demonstrated the beneficial effects of consuming n-3 PUFA in preventing the complications of lipotoxicity. n-3 PUFA dietary intake thus had positive effects on fatty liver in patients with non-alcoholic fatty liver disease (NAFLD), with an improvement in liver echotexture and a significant regression of hepatic brightness, associated with improved liver hemodynamics. The n-3 PUFA also had beneficial effects on ectopic fat accumulation inside the heart, with stabilization of cardiac myocytes and antiarrhythmic effects. On the other hand, recent data from animal models suggest that oral dosing of eicosapentaenoic acid (EPA) could contribute to protect against P-cell lipotoxicity. This review discusses the latest hypotheses regarding lipotoxicity, concentrating on the impact of the n-3 PUFA that contribute to ectopic lipid storage, affecting organ function. Further human studies are needed to test the evidence and elucidate the mechanisms involved in this process. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Perez-Martinez, Pablo; Perez-Jimenez, Francisco; Lopez-Miranda, Jose] Univ Cordoba, Lipids & Atherosclerosis Res Unit, Reina Sofia Univ Hosp, IMIBIC,Inst Salud Carlos III, E-14004 Cordoba, Spain.
C3 Instituto de Salud Carlos III; Universidad de Cordoba; Hospital
   Universitario Reina Sofia - Cordoba
RP Lopez-Miranda, J (corresponding author), Univ Cordoba, Lipids & Atherosclerosis Res Unit, Reina Sofia Univ Hosp, IMIBIC,Inst Salud Carlos III, Avda Menendez Pidal S-N, E-14004 Cordoba, Spain.
EM jlopezmir@uco.es
RI Jimenez, Francisco/AAJ-9559-2021; Lopez-Miranda, Jose/Y-8306-2019; Perez
   Martinez, Pablo/AEL-6176-2022
OI Perez-Jimenez, Francisco/0000-0001-7499-7681; Perez Jimenez,
   Francisco/0000-0001-9808-1280; Perez Martinez,
   Pablo/0000-0001-7716-8117; Lopez-Miranda, Jose/0000-0002-8844-0718
FU Consejeria de Salud; Consejeria de Innovacion; Proyecto de Investigacion
   de Excelencia; Junta de Andalucia [P06-CTS-01425]; Spanish Ministry of
   Education and Science [AGL2006-01979/ALI, AGL2009-12270/ALI]; Spanish
   Ministry of Health [CB06/03/0047]
FX Source of support: This study was supported in part by research grants
   from the Consejeria de Salud, Consejeria de Innovacion, Proyecto de
   Investigacion de Excelencia, Junta de Andalucia (P06-CTS-01425), the
   Spanish Ministry of Education and Science (AGL2006-01979/ALI,
   AGL2009-12270/ALI), and the Spanish Ministry of Health (CB06/03/0047
   (CIBER Fisiopatologia de la Obesidad y Nutricion is an initiative of
   ISCIII)).
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NR 61
TC 43
Z9 46
U1 1
U2 37
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1388-1981
EI 1879-2618
J9 BBA-MOL CELL BIOL L
JI Biochim. Biophys. Acta Mol. Cell Biol. Lipids
PD MAR
PY 2010
VL 1801
IS 3
SI SI
BP 362
EP 366
DI 10.1016/j.bbalip.2009.09.010
PG 5
WC Biochemistry & Molecular Biology; Biophysics; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Cell Biology
GA 568YT
UT WOS:000275563300020
PM 19781663
DA 2025-06-11
ER

PT J
AU Donoho, CJ
   Weigensberg, MJ
   Emken, BA
   Hsu, JW
   Spruijt-Metz, D
AF Donoho, Carrie J.
   Weigensberg, Marc J.
   Emken, B. Adar
   Hsu, Ja-Wen
   Spruijt-Metz, Donna
TI Stress and Abdominal Fat: Preliminary Evidence of Moderation by the
   Cortisol Awakening Response in Hispanic Peripubertal Girls
SO OBESITY
LA English
DT Article
ID SUBCUTANEOUS ADIPOSE-TISSUE; ADRENAL AXIS ACTIVITY; MAGNETIC-RESONANCE;
   METABOLIC SYNDROME; VISCERAL OBESITY; WHITEHALL-II; RISK; CHILDREN;
   HEALTH; WOMEN
AB Stress and the cortisol awakening response (CAR) have been independently linked to increases in abdominal fat depots. This cross-sectional study examined the CAR as a moderator of the association between stress, visceral adipose tissue (VAT), and subcutaneous abdominal adipose tissue (SAT) in a sample (N = 23) of female peripubertal Hispanic girls aged from 8 to 11. The study included: (i) monitored salivary cortisol collection, (ii) VAT and SAT obtained by multislice magnetic resonance imaging, and (iii) a stressful life events checklist with four domain-specific subscales: peer, family, personal, and school. Regression analysis indicated an interaction of school-related life events and CAR on VAT and SAT, with greater numbers of school-related events being related to greater VAT and SAT for girls with high CAR, but no association with VAT or SAT for girls with low CAR. Similar to job stress in adults, school-related stress in children may contribute to central adiposity, especially for girls with high CAR.
C1 [Donoho, Carrie J.] Univ So Calif, Davis Sch Gerontol, Los Angeles, CA 90089 USA.
   [Donoho, Carrie J.; Emken, B. Adar; Hsu, Ja-Wen; Spruijt-Metz, Donna] Univ So Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90033 USA.
   [Weigensberg, Marc J.] Univ So Calif, Keck Sch Med, Dept Pediat, Los Angeles, CA 90033 USA.
C3 University of Southern California; University of Southern California;
   University of Southern California
RP Donoho, CJ (corresponding author), Univ So Calif, Davis Sch Gerontol, Los Angeles, CA 90089 USA.
EM donoho@usc.edu
FU National Cancer Institute (NCI), NCI Centers for Transdisciplinary
   Research on Energetics and Cancer (TREC) [U54-CA-116848]; National
   Institute on Aging, Multidisciplinary Research Training in Gerontology
   (NIA) [5-T32-AG000037]
FX The National Cancer Institute (NCI), NCI Centers for Transdisciplinary
   Research on Energetics and Cancer (TREC, U54-CA-116848), and the
   National Institute on Aging, Multidisciplinary Research Training in
   Gerontology (NIA, 5-T32-AG000037) provided support for this work. The
   funding sources had no further role in study design; in the collection,
   analysis and interpretation of data; in the writing of the report; and
   in the decision to submit the paper for publication. We thank Ana
   Romero, Adriana Padilla, Britni Belcher, Arianna McClain, and Selena
   Nguyen-Rodriguez for their roles in development, data collection and
   management of this project. We also thank all of the participants and
   their families for their time and dedication to this study.
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NR 42
TC 30
Z9 35
U1 0
U2 6
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 1930-7381
J9 OBESITY
JI Obesity
PD MAY
PY 2011
VL 19
IS 5
BP 946
EP 952
DI 10.1038/oby.2010.287
PG 7
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 755LS
UT WOS:000289933300011
PM 21127479
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Van Buiten, CB
   Wu, GJ
   Lam, YY
   Zhao, LP
   Raskin, I
AF Van Buiten, Charlene B.
   Wu, Guojun
   Lam, Yan Y.
   Zhao, Liping
   Raskin, Ilya
TI Elemental iron modifies the redox environment of the gastrointestinal
   tract: A novel therapeutic target and test for metabolic syndrome
SO FREE RADICAL BIOLOGY AND MEDICINE
LA English
DT Article
DE Iron; Metabolic syndrome; Reactive oxygen species; Leaky gut; Microbiome
ID GUT MICROBIOTA; AKKERMANSIA-MUCINIPHILA; INTESTINAL INFLAMMATION;
   INSULIN-RESISTANCE; OXYGEN; DIET; OBESITY; INGESTION; ABUNDANCE; STRESS
AB Metabolic syndrome (MetS, i.e., type 2 diabetes and obesity) is often associated with dysbiosis, inflammation, and leaky gut syndrome, which increase the content of oxygen and reactive oxygen species (ROS) in the gastrointestinal (GI) tract. Using near-infrared fluorescent, in situ imaging of ROS, we evaluated the effects of oral administration of elemental iron powder (Fe0) on luminal ROS in the GI tract and related these changes to glucose metabolism and the gut microbiome. C57Bl/6J mice fed low-fat or high-fat diets and gavaged with Fe0 (2.5 g per kg), in both single- and repeat-doses, demonstrated decreased levels of luminal ROS. Fourteen days of repeated Fe0 administration reduced hyperglycemia and improved glucose tolerance in the obese and hyperglycemic animals compared to the untreated obese controls and reduced the relative amount of iron oxides in the feces, which indicated an increased redox environment of the GI tract. We determined that Fe0 administration can also be used as a diagnostic assay to assess the GI microenvironment. Improved metabolic outcomes and decreased gastrointestinal ROS in Fe0-treated, high-fat diet-fed animals correlated with the increase in a coabundance group of beneficial bacteria, including Lactobacillus, and the suppression of detrimental populations, including Oscillibacter, Peptococcus, and Intestinimonas. Daily Fe0 treatment also increased the relative abundance of amplicon sequence variants that lacked functional enzymatic antioxidant systems, which is consistent with the ability of Fe0 to scavenge ROS and oxygen in the GI, thus favoring the growth of oxygensensitive bacteria. These findings delineate a functional role for antioxidants in modification of the GI microenvironment and subsequent reversal of metabolic dysfunction.
C1 [Van Buiten, Charlene B.] Colorado State Univ, Coll Hlth & Human Sci, Dept Food Sci & Human Nutr, Ft Collins, CO 80525 USA.
   [Van Buiten, Charlene B.; Raskin, Ilya] Rutgers State Univ, Sch Environm & Biol Sci, Dept Plant Biol, New Brunswick, NJ 08901 USA.
   [Wu, Guojun; Lam, Yan Y.; Zhao, Liping] Rutgers State Univ, Sch Environm & Biol Sci, Dept Biochem & Microbiol, New Brunswick, NJ 08901 USA.
   [Wu, Guojun; Lam, Yan Y.; Zhao, Liping] Rutgers State Univ, Ctr Microbiome, New Jersey Inst Food Nutr & Hlth, New Brunswick, NJ 80901 USA.
C3 Colorado State University System; Colorado State University Fort
   Collins; Rutgers University System; Rutgers University New Brunswick;
   Rutgers University System; Rutgers University New Brunswick; Rutgers
   University System; Rutgers University New Brunswick
RP Van Buiten, CB (corresponding author), Colorado State Univ, Coll Hlth & Human Sci, Dept Food Sci & Human Nutr, Ft Collins, CO 80525 USA.
EM charlene.vanbuiten@colostate.edu
RI Zhao, Liping/AEA-4833-2022; Van Buiten, Charlene/AFT-5465-2022; Wu,
   Guuojun/AHB-4249-2022
OI Van Buiten, Charlene B./0000-0001-9613-9100; Raskin,
   Ilya/0000-0002-3025-8112; Wu, Guojun/0000-0002-7910-2813
FU National Center for Complementary and Integrative Health, National
   Institute of Health (NIH-NCCIH) [1R01AT008618-01]; NIH-NCCIH
   [5T32AT004094]
FX This work was partially funded by the National Center for Complementary
   and Integrative Health, National Institute of Health (NIH-NCCIH) grant
   (1R01AT008618-01) and CBV was funded by an NIH-NCCIH Training Grant
   (5T32AT004094).
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NR 74
TC 5
Z9 7
U1 3
U2 20
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0891-5849
EI 1873-4596
J9 FREE RADICAL BIO MED
JI Free Radic. Biol. Med.
PD MAY 20
PY 2021
VL 168
BP 203
EP 213
DI 10.1016/j.freeradbiomed.2021.03.032
EA APR 2021
PG 11
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA RQ4AK
UT WOS:000642362400001
PM 33831549
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Zec, MM
   Krga, I
   Takic, M
   Debeljak-Martacic, J
   Koricanac, G
   Rankovic, S
   Popovic, T
   Pantelic, M
   Glibetic, M
AF Zec, Manja M.
   Krga, Irena
   Takic, Marija
   Debeljak-Martacic, Jasmina
   Koricanac, Goran
   Rankovic, Slavica
   Popovic, Tamara
   Pantelic, Marija
   Glibetic, Maria
TI Walnut Consumption Induces Tissue-Specific Omega-6/Omega-3 Decrease in
   High-Fructose-Fed Wistar Rats
SO ACS OMEGA
LA English
DT Article
ID FATTY-ACID-COMPOSITION; DE-NOVO LIPOGENESIS; INSULIN-RESISTANCE;
   METABOLIC SYNDROME; OXIDATIVE STRESS; ADIPOSE-TISSUE; BLOOD-PRESSURE;
   MIXED NUTS; SERUM; LIVER
AB Increased dietary, blood, and tissue n-6/n-3 fatty acid ratios are associated with obesity and metabolic syndrome. Due to Westernized dietary patterns, the increasing n-6/n-3 ratio is of growing concern worldwide, and dietary strategies aimed at its lowering are of public health importance. Walnuts are rich in dietary fats, and their consumption promotes cardiometabolic health. This study aimed to examine the effect of 6-week walnut consumption on tissue-specific n-6/n-3 ratio and fatty acid metabolic conversion in fructose-fed rats with a cluster of metabolic disorders. Male Wistar rats were fed a standard diet with or without 10% fructose in drinking water for 9 weeks. Diets of half of the animals were then supplemented with walnuts (2.4 g/day) for 6 weeks, upon which fatty acid profiles were determined in plasma, liver, adipose tissue, and kidney total lipids. Results showed that walnuts induced significant decreases in the n-6/n-3 content of total lipid pool in plasma and examined tissues, irrespective of metabolic burden. Walnut intervention decreased plasma and liver palmitoleic/palmitic, arachidonic/linoleic, and docosahexaenoic/alpha-linolenic acid ratios. It also modulated individual fatty acid levels by reducing arachidonic and palmitic acid and increasing alpha-linolenic, eicosapentaenoic, and docosapentaenoic acid in plasma and most tissues. Our study demonstrated that 6-week consumption of walnuts favorably modulated n-6/n-3 plasma and tissue ratio in male Wistar rats regardless of high-fructose feeding, underscoring the promising potential of walnuts in both prevention and treatment of the metabolic syndrome.
C1 [Zec, Manja M.; Krga, Irena; Takic, Marija; Debeljak-Martacic, Jasmina; Rankovic, Slavica; Popovic, Tamara; Glibetic, Maria] Univ Belgrade, Ctr Excellence Nutr & Metab Res, Inst Med Res, Natl Inst Republ Serbia, Belgrade 11000, Serbia.
   [Koricanac, Goran; Pantelic, Marija] Univ Belgrade, Vinca Inst Nucl Sci, Natl Inst Republ Serbia, Lab Mol Biol & Endocrinol, Belgrade 11001, Serbia.
C3 University of Belgrade; University of Belgrade
RP Zec, MM (corresponding author), Univ Belgrade, Ctr Excellence Nutr & Metab Res, Inst Med Res, Natl Inst Republ Serbia, Belgrade 11000, Serbia.
EM manjazecimr@gmail.com
RI Korićanac, Goran/ABF-6544-2021; Pantelic, Marija/NBX-1547-2025; Krga,
   Irena/AAC-4879-2020; Zec, Manja/T-5942-2019
OI Koricanac, Goran/0000-0002-9852-3330; Pantelic,
   Marija/0000-0001-8457-0585; Debeljak Martacic,
   Jasmina/0000-0002-9605-3793; Zec, Manja/0000-0001-5283-9295; Krga,
   Irena/0000-0002-2073-2896
FU Ministry of Education, Science and Technological Development of the
   Republic of Serbia [451-03-68/2020-14/200015, 451-03-68/2020-14/200017]
FX This work was supported by the Ministry of Education, Science and
   Technological Development of the Republic of Serbia, under the contract
   numbers 451-03-68/2020-14/200015 and 451-03-68/2020-14/200017.
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NR 56
TC 11
Z9 12
U1 1
U2 4
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 2470-1343
J9 ACS OMEGA
JI ACS Omega
PD NOV 3
PY 2020
VL 5
IS 43
BP 28136
EP 28145
DI 10.1021/acsomega.0c03784
PG 10
WC Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry
GA OR1NS
UT WOS:000589243500042
PM 33163796
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Pahwa, R
   Singh, A
   Adams-Huet, B
   Devaraj, S
   Jialal, I
AF Pahwa, Roma
   Singh, Anand
   Adams-Huet, Beverley
   Devaraj, Sridevi
   Jialal, Ishwarlal
TI Increased inflammasome activity in subcutaneous adipose tissue of
   patients with metabolic syndrome
SO DIABETES-METABOLISM RESEARCH AND REVIEWS
LA English
DT Article
DE adipose tissue; caspase 1; inflammasome; inflammation; interleukin
   1(IL-1); interleukin 18 (IL-18); metabolic syndrome
ID LIPOPOLYSACCHARIDE-BINDING PROTEIN; GROUP BOX PROTEIN-1; NLRP3
   INFLAMMASOME; INSULIN-RESISTANCE; NALP3 INFLAMMASOME; OXIDATIVE STRESS;
   URIC-ACID; ACTIVATION; OBESITY; TOLL
AB Aims The metabolic syndrome (MetS) is an inflammatory disorder associated with an increased risk for diabetes and atherosclerotic cardiovascular disease (ASCVD). Studies in patients and animal models of obesity and diabetes have shown increased NOD-like receptor family pyrin domain containing 3 (NLPR3) inflammasome activity. However, there is scanty data on the activity of the NLRP3 inflammasome in patients with nascent MetS. The aim of this study was to determine the status of the inflammasome in subcutaneous adipose tissue (SAT) of patients with nascent MetS without concomitant diabetes, ASCVD and smoking. Materials and Methods Patients with nascent MetS and controls were recruited from Sacramento County. Fasting blood samples were collected for biomediators of inflammation and SAT was obtained by biopsy for immunohistochemical (IHC) staining for caspase 1, IL-1 beta and IL-18. Results Caspase1, a marker of inflammasome activity and its downstream mediators IL-1 beta and IL-18 were significantly increased in SAT of patients with MetS compared to controls. Significant positive correlations of caspase 1 were obtained with certain cardio-metabolic features, biomediators of inflammation and markers of angiogenesis and fibrosis in SAT. Both mast cell and eosinophil abundance but not macrophage density correlated with caspase1. Conclusions We make the novel observation that the SAT of patients with nascent MetS displays increased NLRP3 inflammasome activity manifest by increased caspase 1 in SAT and this may contribute to increased insulin resistance, inflammation and SAT fibrosis in these patients.
C1 [Pahwa, Roma; Singh, Anand] NCI, NIH, Bethesda, MD 20892 USA.
   [Adams-Huet, Beverley] UT Southwestern Med Ctr, Ctr Biostat & Clin Sci, Dallas, TX USA.
   [Devaraj, Sridevi] Texas Childrens Hosp, Houston, TX 77030 USA.
   [Devaraj, Sridevi] Baylor Coll Med, Houston, TX 77030 USA.
   [Jialal, Ishwarlal] VA Med Ctr, 10535 Hosp Way, Mather, CA 95655 USA.
C3 National Institutes of Health (NIH) - USA; NIH National Cancer Institute
   (NCI); University of Texas System; University of Texas Southwestern
   Medical Center Dallas; Baylor College of Medicine; Baylor College
   Medical Hospital; Baylor College of Medicine
RP Jialal, I (corresponding author), VA Med Ctr, 10535 Hosp Way, Mather, CA 95655 USA.
EM kjialal@gmail.com
RI Singh, Anand/KXR-8053-2024
OI Singh, Anand/0000-0003-4360-929X; Pahwa, Roma/0009-0006-0745-3581
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NR 53
TC 19
Z9 21
U1 0
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1520-7552
EI 1520-7560
J9 DIABETES-METAB RES
JI Diabetes-Metab. Res. Rev.
PD MAR
PY 2021
VL 37
IS 3
AR e3383
DI 10.1002/dmrr.3383
EA AUG 2020
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA QX9GJ
UT WOS:000556096200001
PM 32652811
DA 2025-06-11
ER

PT J
AU Kosgei, VJ
   Coelho, D
   Guéant-Rodriguez, RM
   Guéant, JL
AF Kosgei, Viola J.
   Coelho, David
   Gueant-Rodriguez, Rosa-Maria
   Gueant, Jean-Louis
TI Sirt1-PPARS Cross-Talk in Complex Metabolic Diseases and Inherited
   Disorders of the One Carbon Metabolism
SO CELLS
LA English
DT Review
DE Sirtuin1; peroxisome proliferator-activated receptor-gamma coactivator-1
   alpha; peroxisome proliferator activated receptors; obesity; metabolic
   syndrome; vitamin B12; folate; fetal programming; inherited metabolic
   disorders
ID PANCREATIC BETA-CELLS; FATTY-ACID OXIDATION; NF-KAPPA-B; INSULIN
   SENSITIVITY; SKELETAL-MUSCLE; ADIPOSE-TISSUE; HEPATIC STEATOSIS;
   RESVERATROL SUPPLEMENTATION; INFLAMMATORY PROCESSES; MATERNAL NUTRITION
AB Sirtuin1 (Sirt1) has a NAD (+) binding domain and modulates the acetylation status of peroxisome proliferator-activated receptor-gamma coactivator-1 alpha (PGC1 alpha) and Fork Head Box O1 transcription factor (Foxo1) according to the nutritional status. Sirt1 is decreased in obese patients and increased in weight loss. Its decreased expression explains part of the pathomechanisms of the metabolic syndrome, diabetes mellitus type 2 (DT2), cardiovascular diseases and nonalcoholic liver disease. Sirt1 plays an important role in the differentiation of adipocytes and in insulin signaling regulated by Foxo1 and phosphatidylinositol 3 '-kinase (PI3K) signaling. Its overexpression attenuates inflammation and macrophage infiltration induced by a high fat diet. Its decreased expression plays a prominent role in the heart, liver and brain of rat as manifestations of fetal programming produced by deficit in vitamin B12 and folate during pregnancy and lactation through imbalanced methylation/acetylation of PGC1 alpha and altered expression and methylation of nuclear receptors. The decreased expression of Sirt1 produced by impaired cellular availability of vitamin B12 results from endoplasmic reticulum stress through subcellular mislocalization of ELAVL1/HuR protein that shuttles Sirt1 mRNA between the nucleus and cytoplasm. Preclinical and clinical studies of Sirt1 agonists have produced contrasted results in the treatment of the metabolic syndrome. A preclinical study has produced promising results in the treatment of inherited disorders of vitamin B12 metabolism.
C1 [Kosgei, Viola J.; Coelho, David; Gueant-Rodriguez, Rosa-Maria; Gueant, Jean-Louis] Univ Lorraine, UMR Inserm N GERE Nutr Genet & Exposit Risques En, F-54500 Vandoeuvre Les Nancy, France.
   [Gueant-Rodriguez, Rosa-Maria; Gueant, Jean-Louis] Univ Lorraine, Univ Hosp Ctr, Dept Digest Dis, F-54500 Vandoeuvre Les Nancy, France.
   [Gueant-Rodriguez, Rosa-Maria; Gueant, Jean-Louis] Univ Lorraine, Univ Hosp Ctr, Dept Nutr & Endocrinol, F-54500 Vandoeuvre Les Nancy, France.
   [Gueant-Rodriguez, Rosa-Maria; Gueant, Jean-Louis] Univ Lorraine, Univ Hosp Ctr, Dept Mol Med, F-54500 Vandoeuvre Les Nancy, France.
   [Gueant-Rodriguez, Rosa-Maria; Gueant, Jean-Louis] Univ Lorraine, Univ Hosp Ctr, Natl Ctr Inborn Errors Metab, F-54500 Vandoeuvre Les Nancy, France.
C3 Universite de Lorraine; Institut National de la Sante et de la Recherche
   Medicale (Inserm); CHU de Nancy; Universite de Lorraine; CHU de Nancy;
   Universite de Lorraine; CHU de Nancy; Universite de Lorraine; Universite
   de Lorraine; CHU de Nancy
RP Guéant, JL (corresponding author), Univ Lorraine, UMR Inserm N GERE Nutr Genet & Exposit Risques En, F-54500 Vandoeuvre Les Nancy, France.; Guéant, JL (corresponding author), Univ Lorraine, Univ Hosp Ctr, Dept Digest Dis, F-54500 Vandoeuvre Les Nancy, France.; Guéant, JL (corresponding author), Univ Lorraine, Univ Hosp Ctr, Dept Nutr & Endocrinol, F-54500 Vandoeuvre Les Nancy, France.; Guéant, JL (corresponding author), Univ Lorraine, Univ Hosp Ctr, Dept Mol Med, F-54500 Vandoeuvre Les Nancy, France.; Guéant, JL (corresponding author), Univ Lorraine, Univ Hosp Ctr, Natl Ctr Inborn Errors Metab, F-54500 Vandoeuvre Les Nancy, France.
EM viokos84@yahoo.com; david.coelho@univ-lorraine.fr;
   rosa-maria.gueant-rodriguez@univ-lorraine.fr;
   jean-louis.gueant@univ-lorraine.fr
RI Guéant-Rodriguez, Rosa-Maria/ABK-8588-2022; Gueant,
   Jean-Louis/N-7298-2016; Coelho, David/F-6680-2011
OI Gueant, Jean-Louis/0000-0002-5067-042X; Coelho,
   David/0000-0001-7010-5789
FU FHU ARRIMAGE; French PIA project "Lorraine Universite d'Excellence"
   [ANR-15-IDEX-04-LUE]
FX This research was funded by FHU ARRIMAGE and the French PIA project
   "Lorraine Universite d'Excellence", reference ANR-15-IDEX-04-LUE.
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NR 135
TC 43
Z9 44
U1 2
U2 19
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2073-4409
J9 CELLS-BASEL
JI Cells
PD AUG
PY 2020
VL 9
IS 8
AR 1882
DI 10.3390/cells9081882
PG 18
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA NL0VK
UT WOS:000567143500001
PM 32796716
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Miettola, J
   Viljanen, AM
AF Miettola, Juhani
   Viljanen, Anna Maria
TI A salutogenic approach to prevention of metabolic syndrome: a mixed
   methods population study
SO SCANDINAVIAN JOURNAL OF PRIMARY HEALTH CARE
LA English
DT Article
DE Finland; general practice; metabolic syndrome; mixed-methods research;
   salutogenesis
ID QUALITY-OF-LIFE; COHERENCE SCALE; ANTONOVSKYS SENSE; HEALTH; PREVALENCE;
   GENDER; ADULTS; RISK
AB Objective. To find a salutogenic approach for prevention of metabolic syndrome in primary care practice. Design. An explanatory sequential mixed-methods procedure was used to fi nd salutogenic approaches for lifestyle change by assessing individual need, potential, and personal motivation. Data from a population health survey and interviews that focused on a sense of coherence were analysed. Subjects. Altogether 480 Finnish subjects participated in a population health survey, and 43 of them were interviewed. The 43 interviewees' data were included in the fi nal analysis. Main outcome measures. With the health survey participants' liability for MetS was assessed, and the objective need for lifestyle intervention was determined. Through the focused interviews potential and personal motivation for lifestyle modifi cation were explored. Finally the data of the 43 interviewed subjects were merged. Results. Four possible lifestyle intervention approaches were identifi ed for specifi c intervention. First, subjects with a strong sense of coherence only need encouragement to maintain a healthy lifestyle; second, professional support was found important for subjects with gaps in health awareness to improve health understanding; third, strengthening of social support for lifestyle change is necessary for subjects with various practical constraints in their everyday life; and fourth, strengthening of stress adaptation is important for subjects with redundant concerns about their health. Conclusions. Salutogenic client-centred lifestyle modifi cation approaches should be part of primary care practice. Further, a cross-disciplinary approach is needed in primary care research and practice to combat the exploding lifestyle illnesses.
C1 [Miettola, Juhani] Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland.
   [Viljanen, Anna Maria] Univ Helsinki, Dept Social Sci Social & Cultural Anthropol, FIN-00014 Helsinki, Finland.
C3 University of Eastern Finland; University of Helsinki
RP Miettola, J (corresponding author), Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland.
EM juhani.miettola@gmail.com
FU municipality of Lapinlahti; Finnish Cultural Foundation; Development
   Programme for the Prevention and Care of Diabetes in Finland (DEHKO/D2D)
   through the Northern Savo Hospital District
FX The study would not have been possible without the financial support of
   the municipality of Lapinlahti, Finnish Cultural Foundation and the
   Development Programme for the Prevention and Care of Diabetes in Finland
   (DEHKO/D2D) through the Northern Savo Hospital District.
CR [Anonymous], 2009, Motivational interviewing: Preparing people for change
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NR 27
TC 10
Z9 12
U1 0
U2 5
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 0281-3432
EI 1502-7724
J9 SCAND J PRIM HEALTH
JI Scand. J. Prim. Health Care
PD DEC
PY 2014
VL 32
IS 4
BP 217
EP 225
DI 10.3109/02813432.2014.982372
PG 9
WC Health Care Sciences & Services; Primary Health Care; Medicine, General
   & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Health Care Sciences & Services; General & Internal Medicine
GA AW2HK
UT WOS:000346108700011
PM 25424465
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Ceolotto, G
   De Kreutzenberg, SV
   Cattelan, A
   Fabricio, ASC
   Squarcina, E
   Gion, M
   Semplicini, A
   Fadini, GP
   Avogaro, A
AF Ceolotto, Giulio
   De Kreutzenberg, Saula Vigili
   Cattelan, Arianna
   Fabricio, Aline S. C.
   Squarcina, Elisa
   Gion, Massimo
   Semplicini, Andrea
   Fadini, Gian Paolo
   Avogaro, Angelo
TI Sirtuin 1 stabilization by HuR represses TNF-α-and glucose-induced
   E-selectin release and endothelial cell adhesiveness in vitro:
   relevance to human metabolic syndrome
SO CLINICAL SCIENCE
LA English
DT Article
DE cell adhesion; diabetes; endothelial dysfunction; inflammation;
   metabolic syndrome; transcription factor
ID SOLUBLE E-SELECTIN; INTERCELLULAR-ADHESION MOLECULE-1; HIGH SERUM
   CONCENTRATIONS; PROTEIN-KINASE-C; KAPPA-B; OXIDATIVE STRESS; ENHANCES
   ICAM-1; EXPRESSION; VCAM-1; RESVERATROL
AB Chronic inflammation and hyperglycaemia, typical features of metabolic diseases, trigger endothelial damage and release of E-selectin, a marker of endothelial activation. In the present study, we investigated molecular pathways involved in the regulation of endothelial cell activation induced by tumour necrosis factor-alpha (TNF-alpha) and high glucose. In cultured human umbilical vein endothelial cells (HUVECs), we studied the role of HuR, an ELAV (embryonic lethal, abnormal vision, Drosophila) family RNA-binding protein, and Sirtuin 1 (SIRT1) on E-selectin release and cell adhesion at different glucose concentrations. HuR expression and binding to SIRT1 were also analysed ex vivo in peripheral blood mononuclear cells (PBMCs) of subjects with and without the metabolic syndrome (MS), by immunoprecipitation (IP) of the ribonucleoprotein (RNP) complex. We found that SIRT1 overexpression prevented TNF-alpha- and high-glucose-dependent nuclear factor-kappa B (NF-kappa B)-p65 acetylation, E-selectin promoter activity, E-selectin release and adhesion of THP-1 cells to HUVECs. The same was mimicked by HuR overexpression, which binds and stabilizes SIRT1 mRNA. Importantly, in PBMCs of individuals with MS compared with those without, SIRT1 expression was lower, and the ability of HuR to bind SIRT1 mRNA was significantly reduced, while plasma E-selectin was increased. We conclude that post-transcriptional stabilization of SIRT1 by HuR represses inflammation- and hyperglycaemia-induced E-selectin release and endothelial cell activation. Therefore, increasing SIRT1 expression represents a strategy to counter the accelerated vascular disease in metabolic disorders.
C1 [Ceolotto, Giulio; De Kreutzenberg, Saula Vigili; Cattelan, Arianna; Semplicini, Andrea; Fadini, Gian Paolo; Avogaro, Angelo] Univ Padua, Dept Med DIMED, Padua, Italy.
   [Fabricio, Aline S. C.; Squarcina, Elisa; Gion, Massimo] ULSS 12, Reg Ctr Diagnost Prognost & Predict Biomarkers, Dept Clin Pathol, Venice, Italy.
C3 University of Padua; ULSS 3 Serenissima
RP Avogaro, A (corresponding author), Univ Padua, Dept Med DIMED, Padua, Italy.
EM angelo.avogaro@unipd.it
RI de Kreutzenberg, S./AAA-4277-2022; Avogaro, Angelo/S-3808-2016; Fadini,
   Gian/M-4575-2019; Fabricio, Aline/H-3121-2011; Gion,
   Massimo/J-8716-2018; CATTELAN, ANNA/AAL-3654-2020; Semplicini,
   Andrea/B-5959-2013
OI Fabricio, Aline/0000-0003-0153-8809; FADINI, GIAN
   PAOLO/0000-0002-6510-2097; Ceolotto, Giulio/0000-0002-4687-8033;
   Semplicini, Andrea/0000-0003-0652-0739; AVOGARO,
   ANGELO/0000-0002-1177-0516; Cattelan, Anna Maria/0000-0003-2869-2945
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NR 50
TC 36
Z9 43
U1 0
U2 22
PU PORTLAND PRESS LTD
PI LONDON
PA 5TH FLR, 90 HIGH HOLBORN, LONDON WC1V 6LJ, ENGLAND
SN 0143-5221
EI 1470-8736
J9 CLIN SCI
JI Clin. Sci.
PD OCT
PY 2014
VL 127
IS 7-8
BP 449
EP 461
DI 10.1042/CS20130439
PG 13
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA AQ1FD
UT WOS:000342526400003
PM 24702436
DA 2025-06-11
ER

PT J
AU Kawarazaki, W
   Fujita, T
AF Kawarazaki, Wakako
   Fujita, Toshiro
TI Aberrant Rac1-mineralocorticoid receptor pathways in salt-sensitive
   hypertension
SO CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
LA English
DT Article
DE aldosterone; aldosterone-releasing factors; kidney; metabolic syndrome;
   mineralocorticoid receptor; obesity; Rac1; salt sensitivity of blood
   pressure; salt-sensitive hypertension
ID ACTIVATED PROTEIN-KINASE; JUN NH2-TERMINAL KINASE; MINERALOCORTICOID
   RECEPTOR; ANGIOTENSIN-II; BLOOD-PRESSURE; INTRACEREBROVENTRICULAR
   INFUSION; METABOLIC SYNDROME; OXIDATIVE STRESS; RAC1 GTPASE; WEIGHT-LOSS
AB According to Guyton's model, impaired renal sodium excretion plays a key role in the increased salt sensitivity of blood pressure (BP). Several factors contribute to impaired renal sodium excretion, including the sympathetic nervous system, the renin-angiotensin system and aldosterone. Accumulating evidence suggests that abnormalities in aldosterone and its receptor (i.e. the mineralocorticoid receptor (MR)) are involved in the development of salt-sensitive (SS) hypertension.
   Patients with metabolic syndrome often exhibit hyperaldosteronism and are susceptible to SS hypertension. Aldosterone secretion from the adrenal glands is not suppressed in obese hypertensive rats fed a high-salt diet because of the abundant production of adipocyte-derived aldosterone-releasing factors, which are independent of the negative feedback regulation of aldosterone secretion by the renin-angiotensin-aldosterone system. Increased plasma aldosterone levels lead to SS hypertension via MR activation in the kidney.
   Renal MR activity is increased in Dahl salt-sensitive rats fed a high-salt diet, despite the appropriate suppression of plasma aldosterone levels. In this rat strain, activation of MR in the distal nephron causes salt-induced hypertension. This paradoxical response of the MR to salt loading can be attributed to activation of Rac1, a small GTPase. In the presence of aldosterone, activated Rac1 synergistically and directly activates MR in a ligand-independent manner. Thus, Rac1 activation in the kidney determines the salt sensitivity of BP. Together, the available evidence suggests that the aberrant Rac1-MR pathway plays a key role in the development of SS hypertension.
C1 [Kawarazaki, Wakako; Fujita, Toshiro] Univ Tokyo 1, Div Clin Epigenet, Res Ctr Adv Sci & Technol 1, Tokyo 1538904, Japan.
RP Fujita, T (corresponding author), Univ Tokyo, Div Clin Epigenet, Res Ctr Adv Sci & Technol, Meguro Ku, 4-6-1 Komaba, Tokyo 1538904, Japan.
EM Toshiro.FUJITA@rcast.u-tokyo.ac.jp
RI Kawarazaki, Wakako/GPP-2721-2022; Kawarazaki, Wakako/LIG-5150-2024
OI Kawarazaki, Wakako/0000-0002-1332-8537
FU Japan Society for the promotion of Science [21229012]; Research Project
   Japan Science and Technology Agency (JST); CREST; Grants-in-Aid for
   Scientific Research [21229012, 24659410] Funding Source: KAKEN
FX The authors' work reported herein was supported by a Grant-in-Aid for
   Scientific Research from the Japan Society for the promotion of Science
   (No. 21229012), as well as grants from the Research Project Japan
   Science and Technology Agency (JST), Strategic Basic Research Programs
   and CREST. The authors thank Inter-Biotec (http://www.interbiotec.com/)
   for the English language editing of this paper.
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NR 72
TC 17
Z9 17
U1 0
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0305-1870
EI 1440-1681
J9 CLIN EXP PHARMACOL P
JI Clin. Exp. Pharmacol. Physiol.
PD DEC
PY 2013
VL 40
IS 12
BP 929
EP 936
DI 10.1111/1440-1681.12177
PG 8
WC Pharmacology & Pharmacy; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Physiology
GA 254HY
UT WOS:000327157000013
PM 24111570
DA 2025-06-11
ER

PT J
AU García-Sánchez, C
   Torres-Tamayo, M
   Juarez-Meavepeña, M
   López-Osorio, C
   Toledo-Ibelles, P
   Monter-Garrido, M
   Cruz-Robles, D
   Carreon-Torres, E
   Vargas-Alarcón, G
   Pérez-Méndez, O
AF Garcia-Sanchez, Cynthia
   Torres-Tamayo, Margarita
   Juarez-Meavepena, Minerva
   Lopez-Osorio, Cristhel
   Toledo-Ibelles, Paola
   Monter-Garrido, Mariana
   Cruz-Robles, David
   Carreon-Torres, Elizabeth
   Vargas-Alarcon, Gilberto
   Perez-Mendez, Oscar
TI Lipid plasma concentrations of HDL subclasses determined by enzymatic
   staining on polyacrylamide electrophoresis gels in children with
   metabolic syndrome
SO CLINICA CHIMICA ACTA
LA English
DT Article
DE High-density lipoproteins; Metabolic syndrome; Dyslipidemia; HDL
   subclasses; Coronary heart disease; Pediatric patients
ID HIGH-DENSITY-LIPOPROTEIN; ELEVATED OXIDATIVE STRESS; INSULIN-RESISTANCE;
   SYNDROME VARIABLES; CHOLESTEROL; ADOLESCENTS; PARTICLES; ABNORMALITIES;
   OVERWEIGHT; CHILDHOOD
AB Background: The antiatherogenic role of different HDL subclasses is still controversial. HDL particles of the same size can have different lipid contents in some physiopathological situations. However, little is known about the plasma lipid levels of HDL subclasses when they are separated by their hydrodynamic diameter.
   Methods: Triglycerides (Tg), phosphatidylcholine (Ph), and cholesterol (C) plasma concentrations of HDL subclasses, were determined by enzymatic staining on polyacrylamide gradient gel (PAGE) in 50 pediatric patients with metabolic syndrome (MS), and 50 control children paired by age and gender. Proteins of HDL subclasses were also stained for the assessment of the relative size distribution of HDL.
   Results: Relative HDL size distribution was shifted to small particles in MS pediatric patients when determined per protein. In contrast, cholesterol plasma concentrations corresponding to the HDL2b, 2a, 3a, and 3b subclasses were decreased: triglycerides of HDL3b and 3c, as well as plasma phospholipids from HDL3c, were elevated in MS patients as compared to controls. The C-to-Ph ratio, considered as indicative of HDL composition, was similar among the 5 HDL subclasses in control subjects, whereas this ratio gradually decreased from large HDL2b to small HDL3c in the MS group. Cholesterol plasma concentrations of HDL subclasses correlated with the components of the MS.
   Conclusions: Lipids of HDL subclasses provide more and accurate information than the relative HDL size distribution determined by protein staining, and may contribute to understand better HDL metabolism and the coronary risk associated to these lipoproteins. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Garcia-Sanchez, Cynthia; Juarez-Meavepena, Minerva; Lopez-Osorio, Cristhel; Toledo-Ibelles, Paola; Monter-Garrido, Mariana; Cruz-Robles, David; Carreon-Torres, Elizabeth; Vargas-Alarcon, Gilberto; Perez-Mendez, Oscar] Inst Nacl Cardiol Ignacio Chavez, Dept Mol Biol, Mexico City 14080, DF, Mexico.
   [Torres-Tamayo, Margarita] Gen Hosp Manuel Gea Gonzalez, Obes Clin, Mexico City, DF, Mexico.
C3 National Institute of Cardiology - Mexico
RP Pérez-Méndez, O (corresponding author), Inst Nacl Cardiol Ignacio Chavez, Dept Mol Biol, Juan Badiano 1,Secc 16, Mexico City 14080, DF, Mexico.
EM opmendez@yahoo.com
RI Pérez-Méndez, Oscar/AAJ-8451-2020; Vargas-Alarcon,
   Gilberto/AEW-0446-2022; Cruz-Robles, David/C-7278-2015
OI Garcia-Sanchez, Cynthia/0000-0003-3521-6955; Vargas-Alarcon,
   Gilberto/0000-0001-7916-5163; Torres-Tamayo,
   Margarita/0000-0002-5655-0875; Carreon-Torres,
   Elizabeth/0000-0003-3600-249X; Cruz-Robles, David/0000-0003-4234-9561
FU CONACYT [102137]
FX We thank Alin Quiroz for her technical contribution. This study was
   partially supported by the CONACYT Grant No. 102137.
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NR 44
TC 25
Z9 26
U1 0
U2 5
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0009-8981
EI 1873-3492
J9 CLIN CHIM ACTA
JI Clin. Chim. Acta
PD JAN 30
PY 2011
VL 412
IS 3-4
BP 292
EP 298
DI 10.1016/j.cca.2010.10.021
PG 7
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA 718IV
UT WOS:000287115400014
PM 21036160
DA 2025-06-11
ER

PT J
AU Gomez, JA
   Rutkowski, DT
AF Gomez, Javier A.
   Rutkowski, D. Thomas
TI Experimental reconstitution of chronic ER stress in the liver reveals
   feedback suppression of BiP mRNA expression
SO ELIFE
LA English
DT Article
ID ENDOPLASMIC-RETICULUM STRESS; UNFOLDED PROTEIN RESPONSE; PROGRAMMED
   CELL-DEATH; LIPID-METABOLISM; LEPTIN RECEPTOR; GENE-EXPRESSION; LINKS
   OBESITY; MOUSE MODEL; IRE1; ATF6
AB Endoplasmic reticulum (ER) stress is implicated in many chronic diseases, but very little is known about how the unfolded protein response (UPR) responds to persistent ER stress in vivo. Here, we experimentally reconstituted chronic ER stress in the mouse liver, using repeated injection of a low dose of the ER stressor tunicamycin. Paradoxically, this treatment led to feedback-mediated suppression of a select group of mRNAs, including those encoding the ER chaperones BiP and GRP94. This suppression was due to both silencing of the ATF6a pathway of UPR-dependent transcription and enhancement of mRNA degradation, possibly via regulated IRE1-dependent decay (RIDD). The suppression of mRNA encoding BiP was phenocopied by ectopic overexpression of BiP protein, and was also observed in obese mice. Our findings suggest that persistent cycles of UPR activation and deactivation create an altered, quasi-stable setpoint for UPR-dependent transcriptional regulationan outcome that could be relevant to conditions such as metabolic syndrome.
C1 [Gomez, Javier A.] Univ Iowa, Carver Coll Med, Grad Program Mol & Cellular Biol, Iowa City, IA USA.
   [Rutkowski, D. Thomas] Univ Iowa, Dept Anat & Cell Biol, Carver Coll Med, Iowa City, IA 52242 USA.
   [Rutkowski, D. Thomas] Univ Iowa, Dept Internal Med, Carver Coll Med, Iowa City, IA 52242 USA.
C3 University of Iowa; University of Iowa; University of Iowa
RP Rutkowski, DT (corresponding author), Univ Iowa, Dept Anat & Cell Biol, Carver Coll Med, Iowa City, IA 52242 USA.; Rutkowski, DT (corresponding author), Univ Iowa, Dept Internal Med, Carver Coll Med, Iowa City, IA 52242 USA.
EM thomas-rutkowski@uiowa.edu
OI Rutkowski, Thomas/0000-0001-6586-4449
FU National Institute of General Medical Sciences [GM115424, GM067795]
FX National Institute of General Medical Sciences GM115424 D Thomas
   RutkowskiNational Institute of General Medical Sciences GM067795 Javier
   A GomezThe funders had no role in study design, data collection and
   interpretation, or the decision to submit the work for publication.
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NR 79
TC 30
Z9 38
U1 1
U2 15
PU ELIFE SCIENCES PUBLICATIONS LTD
PI CAMBRIDGE
PA SHERATON HOUSE, CASTLE PARK, CAMBRIDGE, CB3 0AX, ENGLAND
SN 2050-084X
J9 ELIFE
JI eLife
PD DEC 10
PY 2016
VL 5
AR e20390
DI 10.7554/eLife.20390
PG 22
WC Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics
GA EH4MV
UT WOS:000391746200001
PM 27938665
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Ambrósio, G
   Kaufmann, FN
   Manosso, L
   Platt, N
   Ghisleni, G
   Rodrigues, ALS
   Rieger, DK
   Kaster, MP
AF Ambrosio, Gabriela
   Kaufmann, Fernanda N.
   Manosso, Luana
   Platt, Nicolle
   Ghisleni, Gabriele
   Rodrigues, Ana Lucia S.
   Rieger, Debora K.
   Kaster, Manuella P.
TI Depression and peripheral inflammatory profile of patients with obesity
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Review
DE Depression; Obesity; Body mass index; Inflammation
ID C-REACTIVE PROTEIN; PHYSICAL-ACTIVITY; METABOLIC SYNDROME;
   ADIPOSE-TISSUE; SYMPTOMS; WOMEN; ASSOCIATION; OVERWEIGHT; DISORDER;
   PEOPLE
AB This narrative review will present and discuss clinical data from 16 cross-sectional and 6 longitudinal studies examining the relationship between body mass index (BMI), symptoms of depression and peripheral inflammation. Our aim is to determine which of obesity and depression contributes best to the peripheral low-grade inflammation frequently associated to both conditions. Studies including a complete evaluation of inflammatory markers are scarce and high levels of interleukin-6 (IL-6) and C-reactive protein (CRP) are the most consistent findings associated with obesity and symptoms of depression. Among the cross-sectional studies, seven studies, including a total of 9421 individuals, pointed to BMI as the major factor associated with systemic low-grade inflammation. However, in four studies, including 16,837 individuals, CRP levels remained associated with the symptoms of depression even after correction for BMI, suggestion that in the absence of overweight or obesity other sources of peripheral inflammation might contribute to presence of depressive symptoms. Additionally, another five studies, including 5569 individuals failed to find an association between depression and peripheral inflammation, reinforcing the heterogeneity of this condition. In the longitudinal data, changes in BMI were associated with a reduction in depressive scores at follow-up, after bariatric surgery or after diet. In four longitudinal studies, high levels of CRP were found to be associated with depression even after adjustment for BMI and weight loss, further corroborating the idea that other sources of peripheral inflammation might contribute to depressive symptoms. Thus it seems that both obesity and depressive symptoms can contribute to peripheral inflammation, and once installed the presence of inflammation can contribute to several behavioral alterations that reinforce the cyclic pattern of co-occurrence observed in patients with obesity and MDD. Future clinical studies should focus on strategic efforts to collect new data and to improve or standardize methods for the evaluation of depression, body composition and a more complete inflammatory profile. These approaches are essential for the development of pharmacological and/or non-pharmacological strategies designed to break this cyclic pattern of co-occurrence.
C1 [Ambrosio, Gabriela; Kaufmann, Fernanda N.; Manosso, Luana; Platt, Nicolle; Rodrigues, Ana Lucia S.; Kaster, Manuella P.] Fed Univ Santa Catarina Florianopolis, Dept Biochem, Florianopolis, SC, Brazil.
   [Ghisleni, Gabriele] Univ Catolica Pelotas, Ctr Life & Hlth Sci, Pelotas, RS, Brazil.
   [Rieger, Debora K.] Univ Fed Santa Catarina, Dept Nutr, Florianopolis, SC, Brazil.
C3 Universidade Catolica de Pelotas; Universidade Federal de Pelotas;
   Universidade Federal de Santa Catarina (UFSC)
RP Kaster, MP (corresponding author), Fed Univ Santa Catarina Florianopolis, Dept Biochem, Florianopolis, SC, Brazil.
EM manuella.kaster@ufsc.br
RI Venske, Débora/K-6829-2016; Ghisleni, Gabriele/D-5032-2013; Kaster,
   Manuella/D-5028-2013; Rodrigues, Ana Lucia/P-6869-2015
OI Platt dos Santos, Nicolle/0000-0003-4794-9152; Kaster,
   Manuella/0000-0003-0258-6204; Kurrle Rieger Venske,
   Debora/0000-0002-8726-8899; Ghisleni, Gabriele/0000-0002-1764-6882;
   Rodrigues, Ana Lucia/0000-0001-6285-8780
FU Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq);
   Coordenacao de Aperfeicoamento de Pessoal de Ensino Superior (CAPES)
FX All the authors declare no conflict of interests. This study was
   supported by Conselho Nacional de Desenvolvimento Cientifico e
   Tecnologico (CNPq) and Coordenacao de Aperfeicoamento de Pessoal de
   Ensino Superior (CAPES). MPK and ALSR are CNPq Research Fellows.
CR [Anonymous], PSYCHONEUROENDOCRINO
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NR 62
TC 78
Z9 85
U1 2
U2 15
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
EI 1873-3360
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD MAY
PY 2018
VL 91
BP 132
EP 141
DI 10.1016/j.psyneuen.2018.03.005
PG 10
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA GK5KT
UT WOS:000436214700017
PM 29550676
DA 2025-06-11
ER

PT J
AU Babtan, AM
   Vesa, SC
   Bosca, BA
   Crisan, M
   Mihu, CM
   Baciut, MF
   Dinu, C
   Crisan, B
   Campian, RS
   Feurdean, CN
   Ionel, A
   Bezugly, A
   Bordea, IR
   Ilea, A
AF Babtan, Anida Maria
   Vesa, Stefan Cristian
   Bosca, Bianca Adina
   Crisan, Maria
   Mihu, Carmen Mihaela
   Baciut, Mihaela Felicia
   Dinu, Cristian
   Crisan, Bogdan
   Campian, Radu Septimiu
   Feurdean, Claudia Nicoleta
   Ionel, Anca
   Bezugly, Artur
   Bordea, Ioana Roxana
   Ilea, Aranka
TI High-Frequency Ultrasound Assessment of Skin and Oral Mucosa in
   Metabolic Syndrome Patients-A Cross-Sectional Study
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Article
DE high-frequency ultrasound; oral mucosa; skin; metabolic syndrome;
   inflammation; aging
ID ADIPOSE-TISSUE DENSITY; OXIDATIVE STRESS; AGE; COLLAGEN; DEPTH
AB Background: Exogenous factors (such as sun exposure, smoking habits, and diet) and endogenous (inflammatory status, general diseases) have a direct influence on skin and soft tissue characteristics. The study's objective was to assess the impact of metabolic syndrome (MS) on characteristics of skin layers in sun-exposed and non-exposed maxillofacial tissues evaluated by high-frequency ultrasound (HFU), as a potential diagnosis and monitoring tool for the aging process. Material and methods: The present study included 102 subjects (24 with MS; 78 without MS). Anthropometric parameters and disease history were recorded, and blood samples were harvested in order to assess biochemical parameters of MS. Sun-exposed skin (zygomatic region) and non-exposed oral mucosa of the lower lip were assessed using HFU (DUB(R) cutis, Taberna Pro Medicum) with a 22 MHz probe. Results: Patients with cardiac disease had significantly lower values for epidermis density (p = 0.002). Gender was independently linked to the aged dermis depth (p < 0.001), aged dermis no. of px (pixels) (p < 0.001), dermis depth (p < 0.001), dermis no. of px (p < 0.001), and subcutaneous tissue density (p < 0.001). Patients with MS had thinner epidermis (p = 0.008) and thinner aged dermis (p = 0.037) when compared to non-MS subjects. Conclusion: Patients with MS had thinner epidermis and a lower epidermis number of pixels in sun-exposed skin. Women had lower epidermis density and thicker dermis in sun-exposed skin. Our study showed that HFU, as a non-invasive investigation approach, is useful to diagnose and monitor the aging process in skin and oral mucosa, correlated with skin phenotype pathological conditions.
C1 [Babtan, Anida Maria; Campian, Radu Septimiu; Feurdean, Claudia Nicoleta; Ionel, Anca; Ilea, Aranka] Iuliu Hatieganu Univ Med & Pharm Cluj Napoca, Fac Dent, Oral Rehabil Dept, Babes St 15, Cluj Napoca 400012, Cluj County, Romania.
   [Vesa, Stefan Cristian] Iuliu Hatieganu Univ Med & Pharm Cluj Napoca, Fac Med, Pharmacol Toxicol & Clin Pharmacol Dept, Marinescu St 23, Cluj Napoca 400337, Cluj County, Romania.
   [Bosca, Bianca Adina; Crisan, Maria; Mihu, Carmen Mihaela] Iuliu Hatieganu Univ Med & Pharm Cluj Napoca, Fac Med, Histol Dept, Pasteur St 4, Cluj Napoca 400349, Cluj County, Romania.
   [Baciut, Mihaela Felicia; Dinu, Cristian; Crisan, Bogdan] Iuliu Hatieganu Univ Med & Pharm Cluj Napoca, Fac Dent, Maxillofacial Surg & Implantol Dept, Cardinal Iuliu Hossu St 37, Cluj Napoca 400349, Cluj County, Romania.
   [Bezugly, Artur] Russian Fed Med Biol Agcy, Acad Postgrad Educ, Dermatol & Cosmetol Dept, Moscow 123098, Russia.
   [Bordea, Ioana Roxana] Iuliu Hatieganu Univ Med & Pharm Cluj Napoca, Fac Dent, Oral Hlth Dept, Babes St 15, Cluj Napoca 400012, Cluj County, Romania.
C3 Iuliu Hatieganu University of Medicine & Pharmacy; Iuliu Hatieganu
   University of Medicine & Pharmacy; Iuliu Hatieganu University of
   Medicine & Pharmacy; Iuliu Hatieganu University of Medicine & Pharmacy;
   Iuliu Hatieganu University of Medicine & Pharmacy
RP Vesa, SC (corresponding author), Iuliu Hatieganu Univ Med & Pharm Cluj Napoca, Fac Med, Pharmacol Toxicol & Clin Pharmacol Dept, Marinescu St 23, Cluj Napoca 400337, Cluj County, Romania.
EM anidamaria.babtan@gmail.com; stefanvesa@gmail.com;
   biancabosca@yahoo.com; mcrisan7@yahoo.com; carmenmihu2004@yahoo.com;
   mbaciut@umfcluj.ro; dinu_christian@yahoo.com; crisan.bogdan@umfcluj.ro;
   rcampian@ymail.com; cbraitoru@yahoo.com; anca_ionel@yahoo.com;
   drarturbezugly@gmail.com; roxana.bordea@ymail.com; arankailea@yahoo.com
RI Ilea, Aranka/N-6040-2014; Bezugly, Artur/HHS-0841-2022; Vesa,
   Stefan/I-2481-2019; mihu, carmen/C-2936-2012; Crisan,
   Maria/AAA-4298-2019; Nicoleta, Feurdean/AAO-8526-2021; Boșca,
   Bianca/AAS-7779-2021; Ionel, Anca/LZF-5765-2025; Dinu,
   Cristian/AAB-4732-2022; Bordea, Ioana Roxana/AAK-7454-2020; Baciut,
   Mihaela/AET-0157-2022
OI Vesa, Stefan Cristian/0000-0003-4549-3526; Bordea, Ioana
   Roxana/0000-0001-7166-9949; Babtan, Anida-Maria/0000-0003-0070-4991;
   Baciut, Mihaela/0000-0003-3495-2758; Bosca, Adina
   Bianca/0000-0002-3835-2090; Ilea, Aranka/0000-0002-1033-0906
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NR 36
TC 1
Z9 1
U1 4
U2 12
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD OCT
PY 2021
VL 10
IS 19
AR 4461
DI 10.3390/jcm10194461
PG 12
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA WK2BB
UT WOS:000709535200001
PM 34640479
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Beydoun, MA
   Chen, XL
   Jha, K
   Beydoun, HA
   Zonderman, AB
   Canas, JA
AF Beydoun, May A.
   Chen, Xiaoli
   Jha, Kanishk
   Beydoun, Hind A.
   Zonderman, Alan B.
   Canas, Jose A.
TI Carotenoids, vitamin A, and their association with the metabolic
   syndrome: a systematic review and meta-analysis
SO NUTRITION REVIEWS
LA English
DT Review
DE carotenoids; meta-analysis; metabolic syndrome; vitamin A
ID 3RD NATIONAL-HEALTH; SERUM ANTIOXIDANT CONCENTRATIONS; ARTERY RISK
   DEVELOPMENT; DIABETES-MELLITUS; BETA-CAROTENE; INSULIN-RESISTANCE;
   OXIDATIVE STRESS; LOWER PREVALENCE; CARDIOVASCULAR-DISEASE;
   ALPHA-TOCOPHEROL
AB Context: Modifiable factors that reduce the burden of the metabolic syndrome (MetS), particularly plant-derived biomarkers, have been a recent focus of rising interest. Objective: This systematic review and meta-analysis, which follows PRISMA guidelines, evaluates evidence from a period of 20 years that links vitamin A and carotenoids with the occurrence of MetS and following the PRISMA guidelines. Data Sources: PubMed and Cochrane databases (January 1997 through March 2017) were systematically assessed for studies, including case-control, cross-sectional, and cohort studies, that evaluated the associations of MetS with carotenoids and retinyl esters and retinol (vitamin A). Data Extraction: Key measures of associations were harmonized into odds ratios (ORs) and 95% confidence intervals (95% CI) of MetS per 1 standard deviation (SD) of exposure using forest plots and random effects models that pooled data points from 11 cross-sectional studies. Begg's funnel and harvest plots were constructed. Results: An inverse association between total carotenoids and MetS was found [ORpooled, 0.66; 95% CI, 0.56-0.78; 1 SD similar to 0.82 mu mol/L; n = 5 studies]. This association was the strongest for beta-carotene, followed by alpha-carotene and beta-crypotoxanthin. No association was detected between retinol and MetS (ORpooled, 1.00; 95% CI, 0.88-1.13; 1 SD similar to 2.14 mu mmol/L; n = 6 studies). Publication bias was absent, and harvest plots indicated consistency upon replication for beta-carotene and total carotenoid exposures. Conclusions: This review and meta-analysis suggests that, unlike retinol, total and individual carotenoids were inversely related to MetS.
C1 [Beydoun, May A.; Zonderman, Alan B.] NIA, Lab Epidemiol & Populat Sci, NIH, Intramural Res Program, Baltimore, MD 21224 USA.
   [Chen, Xiaoli] Massachusetts Dept Publ Hlth, Bur Family Hlth & Nutr, Boston, MA USA.
   [Jha, Kanishk] Nemours Childrens Clin, Jacksonville, FL USA.
   [Beydoun, Hind A.] Johns Hopkins Med Inst, Dept Med, Baltimore, MD 21205 USA.
   [Canas, Jose A.] Johns Hopkins All Childrens Hosp, St Petersburg, FL USA.
C3 National Institutes of Health (NIH) - USA; NIH National Institute on
   Aging (NIA); Massachusetts Department of Public Health; Johns Hopkins
   University; Johns Hopkins Medicine; Johns Hopkins University; Johns
   Hopkins Medicine
RP Beydoun, MA (corresponding author), NIA, NIH, Biomed Res Ctr, IRP, 251 Bayview Blvd,Suite 100,Room 04B118, Baltimore, MD 21224 USA.
EM baydounm@mail.nih.gov
RI Zonderman, Alan/A-5807-2013; Canas, Jose/Y-8500-2019; Canas,
   Jose/F-3193-2017
OI Canas, Jose/0000-0003-4788-8820
FU Intramural Research Program of the National Institutes of Health,
   National Institute on Aging
FX This research was supported entirely by the Intramural Research Program
   of the National Institutes of Health, National Institute on Aging.
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NR 83
TC 109
Z9 110
U1 0
U2 35
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0029-6643
EI 1753-4887
J9 NUTR REV
JI Nutr. Rev.
PD JAN
PY 2019
VL 77
IS 1
BP 32
EP 45
DI 10.1093/nutrit/nuy044
PG 14
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA HH8ZS
UT WOS:000456023400003
PM 30202882
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Gruppen, EG
   Connelly, MA
   Otvos, JD
   Bakker, SJL
   Dullaart, RPF
AF Gruppen, Eke G.
   Connelly, Margery A.
   Otvos, James D.
   Bakker, Stephan J. L.
   Dullaart, Robin P. F.
TI A novel protein glycan biomarker and LCAT activity in metabolic syndrome
SO EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
LA English
DT Article
DE Diabetes mellitus; glycoproteins; high-sensitivity C-reactive;
   lecithin:cholesterol acyltransferase; metabolic syndrome
ID LECITHIN-CHOLESTEROL ACYLTRANSFERASE; HIGH-DENSITY-LIPOPROTEIN; PLASMA
   LECITHIN; ANTIOXIDATIVE FUNCTIONALITY; THERAPEUTIC TARGET;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; OXIDIZED LIPIDS; SERUM;
   GLYCOSYLATION
AB BackgroundThe cholesterol-esterifying enzyme, lecithin:cholesterol acyltransferase (LCAT), is instrumental in high-density lipoprotein (HDL) remodelling. LCAT may also modify oxidative and inflammatory processes, as supported by an inverse relationship with HDL antioxidative functionality and a positive relationship with high-sensitivity C-reactive protein (hsCRP). GlycA is a recently developed proton nuclear magnetic resonance (NMR) spectroscopy-measured biomarker of inflammation whose signal originates from a subset of N-acetylglucosamine residues on the most abundant glycosylated acute-phase proteins. Plasma GlycA correlates positively with hsCRP and may predict cardiovascular disease even independent of hsCRP. Here, we tested the extent to which plasma GlycA is elevated in metabolic syndrome (MetS), and determined its relationship with LCAT activity.
   Materials and methodsPlasma GlycA, hsCRP, serum amyloid A (SAA), tumour necrosis factor- (TNF-) and LCAT activity were measured in 58 subjects with MetS (including 46 subjects with type 2 diabetes mellitus (T2DM)) and in 45 nondiabetic subjects without MetS.
   ResultsPlasma GlycA was higher in MetS coinciding with higher hsCRP and LCAT activity (P<001 for each). In all subjects combined, GlycA was correlated positively with hsCRP, SAA and LCAT activity (P<0001 for each), but not with TNF-. Age- and sex-adjusted multivariable linear regression analysis revealed that GlycA was positively associated with LCAT activity (P=0029), independent of the presence of MetS, T2DM, hsCRP and SAA. GlycA was unrelated to diabetes status.
   ConclusionA pro-inflammatory glycoprotein biomarker, GlycA, is higher in MetS. Higher plasma levels of this glycoprotein biomarker relate to increased LCAT activity in the setting of MetS.
C1 [Gruppen, Eke G.; Dullaart, Robin P. F.] Univ Groningen, Univ Med Ctr Groningen, Dept Endocrinol, Groningen, Netherlands.
   [Gruppen, Eke G.; Bakker, Stephan J. L.] Univ Groningen, Univ Med Ctr Groningen, Dept Nephrol, Groningen, Netherlands.
   [Connelly, Margery A.; Otvos, James D.] LabCorp, Raleigh, NC 27616 USA.
C3 University of Groningen; University of Groningen
RP Dullaart, RPF (corresponding author), Univ Groningen, Univ Med Ctr Groningen, Dept Endocrinol, POB 30-001, NL-9700 RB Groningen, Netherlands.
EM r.p.f.dullaart@int.umcg.nl
RI Connelly, Margery/IZP-5440-2023; Bakker, Stephan/J-4023-2015
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NR 55
TC 29
Z9 30
U1 0
U2 10
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0014-2972
EI 1365-2362
J9 EUR J CLIN INVEST
JI Eur. J. Clin. Invest.
PD AUG
PY 2015
VL 45
IS 8
BP 850
EP 859
DI 10.1111/eci.12481
PG 10
WC Medicine, General & Internal; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Research & Experimental Medicine
GA CN3ZP
UT WOS:000358367700010
PM 26081900
DA 2025-06-11
ER

PT J
AU Seres, I
   Fóris, G
   Varga, Z
   Kosztáczky, B
   Kassai, A
   Balogh, Z
   Fülöp, P
   Paragh, G
AF Seres, Ildiko
   Foris, Gabriella
   Varga, Zsuzsa
   Kosztaczky, Bela
   Kassai, Andrea
   Balogh, Zoltan
   Fueloep, Peter
   Paragh, Gyoergy
TI The association between angiotensin II-induced free radical generation
   and membrane fluidity in neutrophils of patients with metabolic syndrome
SO JOURNAL OF MEMBRANE BIOLOGY
LA English
DT Article
DE angiotensin II; free radical; membrane fluidity; neutrophil; metabolic
   syndrome
ID STEAROYL-COA DESATURASE; POLYUNSATURATED FATTY-ACIDS; ALTERED SIGNAL
   PATHWAY; NADPH OXIDASE; PHOSPHOLIPASE A(2); OXIDATIVE STRESS;
   RESPIRATORY BURST; PROTEIN-KINASE; BLOOD-CELLS; EXTRACTION
AB Angiotensin II (Ang II) is able to induce free radical generation in neutrophils, which is more elevated in neutrophils of patients with hypercholesterolemia (HC). In addition, the signal processing through angiotensin I (Ang I) receptors is altered. In present study, we compared the Ang II-triggered free radical generation of neutrophils obtained from patients with relatively isolated forms of metabolic syndrome (MS) with membrane-bound cholesterol content and membrane fluidity. We determined the enhancement of Ang II-induced superoxide anion and leukotriene C-4 (LTC4) generation, membrane fluidity and cell-bound cholesterol content of neutrophils obtained from 12 control subjects, 11 patients with obesity (Ob), 10 patients with type 2 diabetes mellitus (t2-DM) and 12 patients with HC. The alteration of signal processing was studied after preincubation with different inhibiting drugs. Superoxide anion, LTC4 production and membrane rigidity were increased in the following order: control < Ob < t2-DM < HC. Both Ang II-induced superoxide anion and LTC4 generation were decreased in control cells by pertussis toxin and fluvastatin (Flu), whereas in each patient group, mepacrin, verapamil and Flu were effective, suggesting alterations in signal pathways, which may be attributed to isoprenylation. The enhancement of superoxide anion and LTC4 generation correlated signifficantly with membrane rigidity, independently from the experimental groups and membrane-bound cholesterol content. Membrane rigidity of neutrophils, obtained from patients with MS, plays a role in Ang II-induced free radical generation independent of intracellular cholesterol homeostasis.
C1 Univ Debrecen, Dept Med 1, Med & Hlth Sci Ctr, H-4012 Debrecen, Hungary.
C3 University of Debrecen
RP Fóris, G (corresponding author), Univ Debrecen, Dept Med 1, Med & Hlth Sci Ctr, Nagyerdei Krt 98, H-4012 Debrecen, Hungary.
EM forisg@jaguar.unideb.hu
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NR 45
TC 15
Z9 15
U1 0
U2 4
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0022-2631
EI 1432-1424
J9 J MEMBRANE BIOL
JI J. Membr. Biol.
PD NOV
PY 2006
VL 214
IS 1-2
BP 91
EP 98
DI 10.1007/s00232-006-0020-7
PG 8
WC Biochemistry & Molecular Biology; Cell Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology; Physiology
GA 189LT
UT WOS:000247991100008
PM 17546512
DA 2025-06-11
ER

PT J
AU Kwak, J
   Seo, IH
   Lee, YJ
AF Kwak, Jiwon
   Seo, In-Ho
   Lee, Yong-Jae
TI Serum γ-glutamyltransferase level and incidence risk of metabolic
   syndrome in community dwelling adults: longitudinal findings over 12
   years
SO DIABETOLOGY & METABOLIC SYNDROME
LA English
DT Article
DE Metabolic syndrome; gamma-glutamyltransferase; Oxidative stress;
   Epidemiology
ID CARDIOVASCULAR-DISEASE; INSULIN-RESISTANCE; INDEPENDENT PREDICTOR;
   ASSOCIATION; PREVALENCE; GLUTAMYLTRANSFERASE; MORTALITY; ESTROGEN;
   HEALTH
AB Purpose Although a recent meta-analysis demonstrated a positive association between serum gamma-glutamyltransferase (GGT) and metabolic syndrome (MetS), sex differences in the relationship between GGT levels and MetS risk were not fully considered. We prospectively examined the relationship between serum GGT levels and incidence risk of MetS. Methods Data were collected from the Korean Genome and Epidemiology Study (KoGES) enrolled in 2001-2002. Among 10,030 total participants, 5960 adults (3130 men and 2830 women) aged 40-69 without MetS were included and divided according to sex-specific quartiles of baseline serum GGT levels and followed up biennially until 2014. The hazard ratios (HRs) with 95% confidence intervals (CIs) for incident MetS were prospectively analyzed using multiple Cox proportional hazards regression analysis models. Results Among 5960 participants, 1215 males (38.8%) and 1263 females (44.6%) developed MetS during 12-year follow up. Higher quartiles of GGT showed significantly higher cumulative incidence of MetS in both sexes (log-rank test P < 0.001). The HRs (95% CIs) for incident type 2 diabetes for the highest quartile versus referent lowest quartile for serum GGT levels were 3.01 (2.35-3.76) for men and 1.83 (1.30-2.57) for women after adjusting for age, smoking status, daily alcohol intake (g/day), regular exercise, family history of diabetes, and log-transformed LDL-cholesterol, creatinine, and aminotransferase levels. Conclusion In conclusion, high levels of GGT were found to be associated with increased risk of Mets in both men and women and the positive associations were stronger in men than in women.
C1 [Kwak, Jiwon; Seo, In-Ho; Lee, Yong-Jae] Yonsei Univ, Gangnam Severance Hosp, Dept Family Med, Coll Med, 211 Eonju Ro, Seoul 06273, South Korea.
C3 Yonsei University; Yonsei University Health System
RP Lee, YJ (corresponding author), Yonsei Univ, Gangnam Severance Hosp, Dept Family Med, Coll Med, 211 Eonju Ro, Seoul 06273, South Korea.
EM ukyjhome@yuhs.ac
RI SEO, INHO/HPB-7001-2023
OI Lee, Yong-Jae/0000-0002-6697-476X; Seo, In-Ho/0000-0001-8280-7745
FU National Research Foundation (NRF) - Ministry of Science and ICT of
   Korea [NRF-2022R1A2C1013106]
FX This work was supported by the National Research Foundation (NRF) grant
   funded by the Ministry of Science and ICT of Korea [Grant number:
   NRF-2022R1A2C1013106].The sponsors had no role in the conceptualization
   and design of the study, collection and analysis of data, or writing of
   the article.
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NR 44
TC 8
Z9 8
U1 0
U2 0
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1758-5996
J9 DIABETOL METAB SYNDR
JI Diabetol. Metab. Syndr.
PD FEB 23
PY 2023
VL 15
IS 1
DI 10.1186/s13098-023-01000-5
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 9G5DJ
UT WOS:000938172900002
PM 36823659
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Lebensztejn, DM
   Flisiak-Jackiewicz, M
   Bialokoz-Kalinowska, I
   Bobrus-Chociej, A
   Kowalska, I
AF Lebensztejn, Dariusz M.
   Flisiak-Jackiewicz, Marta
   Bialokoz-Kalinowska, Irena
   Bobrus-Chociej, Anna
   Kowalska, Irina
TI Hepatokines and non-alcoholic fatty liver disease
SO ACTA BIOCHIMICA POLONICA
LA English
DT Article; Proceedings Paper
CT 43rd Winter School of
   Faculty-of-Biochemistry-Biophysics-and-Biotechnology of
   Jagiellonian-University on Biomolecules - From Structure to Function
CY FEB 16-20, 2016
CL Zakopane, POLAND
SP Jagiellonian Univ, Fac Biochem, Biophys & Biotechnol
DE non-alcoholic fatty liver disease; fetuin-A; fibroblast growth
   factor-21; selenoprotein P; sex hormone-binding globulin;
   angiopoietin-related growth factor; leukocyte derived chemotaxin 2
ID GROWTH-FACTOR 21; HORMONE-BINDING GLOBULIN; HEPATIC INSULIN-RESISTANCE;
   ENDOPLASMIC-RETICULUM STRESS; CARDIOVASCULAR RISK-FACTORS; C3 GENE
   VARIANTS; PLASMA FETUIN-A; METABOLIC SYNDROME; LIPID-METABOLISM;
   SELENOPROTEIN-P
AB Nowadays non-alcoholic fatty liver disease (NAFLD) is becoming the most common chronic liver pathology both in adults and children. NAFLD manifestation ranges from a simple liver steatosis to steatohepatitis (nonalcoholic steatohepatitis - NASH), which may progress to advanced fibrosis, cirrhosis and end-stage liver disease. Due to the coexistence of visceral obesity, insulin resistance and dyslipidemia, NAFLD is considered to be the hepatic manifestation of metabolic syndrome. In recent years, in the pathogenesis of metabolic syndrome, type 2 diabetes mellitus, cardiovascular disease and also NAFLD, more and more attention has been paid to the so-called organokines, proteins with both paracrine or/and endocrine activities. These include most known adipokines (mainly produced by adipose tissue), myokines (mainly produced by skeletal muscles) and hepatokines exclusively or predominantly produced by the liver. It was shown that the liver may affect the lipids and glucose metabolism by hepatokines released into the blood and NAFLD seems to be associated with altered hepatokines production. Fetuin-A, fibroblast growth factor-21 (FGF-21), selenoprotein P, sex hormone-binding globulin (SHBG), angiopoietin-related growth factor (also known as angiopoietin-related protein 6) and leukocyte derived chemotaxin 2 (LECT2) are considered as the most important hepatokines. In this review, we provide an overview of the main hepatokines and we summarize the association of liver-derived proteins with the development and progression of NAFLD.
C1 [Lebensztejn, Dariusz M.; Flisiak-Jackiewicz, Marta; Bobrus-Chociej, Anna] Med Univ Bialystok, Dept Pediat Gastroenterol & Allergol, Bialystok, Poland.
   [Bialokoz-Kalinowska, Irena] Lomza State Univ Appl Sci, Inst Med, Lomza, Poland.
   [Kowalska, Irina] Med Univ Bialystok, Dept Endocrinol Diabetol & Internal Med, Bialystok, Poland.
C3 Medical University of Bialystok; Medical University of Bialystok
RP Lebensztejn, DM (corresponding author), Med Univ Bialystok, Dept Pediat Gastroenterol & Allergol, Bialystok, Poland.
EM lebensztejn@hoga.pl
RI Lebensztejn, Dariusz/AAE-3166-2020; Bobrus- Chociej, ANNA/S-6710-2018;
   Flisiak-Jackiewicz, Marta/U-9368-2018
OI Bobrus- Chociej, ANNA/0000-0003-2143-4978; Kowalska,
   Irina/0000-0001-9281-1959; Flisiak-Jackiewicz, Marta/0000-0001-5157-8708
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NR 121
TC 71
Z9 73
U1 1
U2 16
PU ACTA BIOCHIMICA POLONICA
PI WARSAW
PA PASTEURA 3, 02-093 WARSAW, POLAND
SN 0001-527X
EI 1734-154X
J9 ACTA BIOCHIM POL
JI Acta Biochim. Pol.
PY 2016
VL 63
IS 3
BP 459
EP 467
DI 10.18388/abp.2015_1252
PG 9
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Biochemistry & Molecular Biology
GA EB7YH
UT WOS:000387606800010
PM 27262842
OA gold
DA 2025-06-11
ER

PT J
AU Abete, I
   Goyenechea, E
   Zulet, MA
   Martínez, JA
AF Abete, I.
   Goyenechea, E.
   Zulet, M. A.
   Martinez, J. A.
TI Obesity and metabolic syndrome: Potential benefit from specific
   nutritional components
SO NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
LA English
DT Review
DE Metabolic syndrome; Dietary treatment; Obesity; Antioxidants; Minerals
   and vitamins
ID ENERGY-RESTRICTED DIETS; LOW-GLYCEMIC INDEX; ORAL MAGNESIUM
   SUPPLEMENTATION; POSTPRANDIAL INSULIN-RESPONSE; POLYUNSATURATED
   FATTY-ACIDS; DISEASE RISK-FACTORS; WEIGHT-LOSS; CARDIOVASCULAR-DISEASE;
   BLOOD-PRESSURE; ANTIOXIDANT STATUS
AB The prevalence of metabolic syndrome (MetS) manifestations is rapidly increasing worldwide, and is becoming an important health problem. Actually, MetS includes a combination of clinical complications such as obesity (central adiposity), insulin resistance, glucose intolerance, dyslipidemia, non-alcoholic fatty liver disease and hypertension. All these alterations predispose individuals to type 2 diabetes and cardiovascular disease inducing earlier mortality rates among people.
   In general terms, it is difficult for patients to follow a standard long-term diet/exercise regime that would improve or alleviate MetS symptoms. Thus, the investigation of food components that may deal with the MetS features is an important field for ameliorate and facilitate MetS dietary-based therapies. Currently antioxidants are of great interest due to the described association between obesity, cardiovascular alterations and oxidative stress. On the other hand, high MUFA and PUFA diets are being also considered due to their potential benefits on hypertension, insulin resistance and triglyceride levels. Mineral composition of the diet is also relevant since high potassium intake may improve hypertension and high calcium consumption may promote lipid oxidation. Thus, although nutritional supplements are at the peak of dietetic therapies, the consumption of some specific foods (legumes, fatty fish, vegetables and fruits, etc) with bioactive components within an energy-restricted diet is a promising approach to manage MetS manifestations. Therefore, the present review focuses on some of the most important food components currently investigated to improve and make easier the nutritional MetS treatment. (C) 2011 Elsevier B.V. All rights reserved.
C1 [Goyenechea, E.] Colegio Oficial Farmaceut, San Sebastian, Spain.
   [Abete, I.; Zulet, M. A.; Martinez, J. A.] Univ Navarra, Dept Ciencias Alimentac Fisiol & Toxicol, E-31080 Pamplona, Navarra, Spain.
C3 University of Navarra
RP Martínez, JA (corresponding author), Univ Navarra, Dept Ciencias Alimentac Fisiol & Toxicol, C Irunlarrea 1, E-31080 Pamplona, Navarra, Spain.
EM jalftmtz@unav.es
RI Martinez, Juan/GXM-4393-2022; Abete, Itziar/H-4827-2017; Zulet, M.
   Angeles/H-1317-2017; Martinez Hernandez, J Alfredo/K-8709-2014
OI ESTIBALIZ, GOYENECHEA/0000-0001-7990-5192; Abete,
   Itziar/0000-0002-6475-5387; Zulet, M. Angeles/0000-0002-3926-0892;
   Martinez Hernandez, J Alfredo/0000-0001-5218-6941
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NR 135
TC 161
Z9 179
U1 2
U2 5
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0939-4753
EI 1590-3729
J9 NUTR METAB CARDIOVAS
JI Nutr. Metab. Carbiovasc. Dis.
PD SEP
PY 2011
VL 21
SU 2
BP B1
EP B15
DI 10.1016/j.numecd.2011.05.001
PG 15
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism; Nutrition
   & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism;
   Nutrition & Dietetics
GA 816LL
UT WOS:000294601300001
PM 21764273
DA 2025-06-11
ER

PT J
AU Rossoni, G
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AF Rossoni, Giuseppe
   Manfredi, Barbara
   Tazzari, Valerio
   Sparatore, Anna
   Trivulzio, Silvio
   Del Soldato, Piero
   Berti, Ferruccio
TI Activity of a new hydrogen sulfide-releasing aspirin (ACS14) on
   pathological cardiovascular alterations induced by glutathione depletion
   in rats
SO EUROPEAN JOURNAL OF PHARMACOLOGY
LA English
DT Article
DE H2S-releasing aspirin; Glutathione depletion; Metabolic syndrome;
   Hypertension; Ischemia/reperfusion
ID OXIDATIVE STRESS; METABOLIC SYNDROME; INSULIN-RESISTANCE; INFLAMMATION;
   ATHEROSCLEROSIS; HYPERTENSION; DYSFUNCTION; INHIBITION; MARKERS
AB We investigated the effects of the hydrogen sulfide (H2S)-releasing derivatives of aspirin (ACS14) and salicylic acid (ACS21) in a rat model of metabolic syndrome induced by glutathione (GSH) depletion, causing hypertension and other pathological cardiovascular alterations. GSH depletion was induced in normal rats by the GSH-synthase inhibitor buthionine sulfoximine (BSO, 30 mmol/L day for seven days in the drinking water). Systolic blood pressure and heart rate were measured daily by the tail-cuff method, and plasma thromboxane B-2, 6-keto-prostaglandin F-2 alpha, 8-isoprostane, GSH, insulin and glucose were determined at the end of the seven-day BSO schedule. In addition. ischemia/reperfusion-induced myocardial dysfunction and endothelial dysfunction were assayed on isolated heart and aortic rings, respectively. Unlike aspirin and salicylic acid, ACS14 and ACS21 reduced BSO-induced hypertension, also lowering plasma levels of thromboxane B-2, 8-isoprostane and insulin, while GSH remained in the control range. Neither ACS14 nor ACS21 caused gastric lesions. Both restored the endothelial dysfunction observed in aortic rings from BSO-treated rats, and in ischemia/reperfusion experiments they lowered left ventricular end-diastolic pressure, consequently improving the developed pressure and the maximum rise and fall of left ventricular pressure. Together with this improvement of heart mechanics there were reductions in the activity of creatine kinase and lactate dehydrogenase in the cardiac perfusate. This implies that H2S released by both ACS14 and ACS21 was involved in protecting the heart from ischemia/reperfusion, and significantly limited vascular endothelial dysfunction in aortic tissue and the related hypertension. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Rossoni, Giuseppe; Manfredi, Barbara; Trivulzio, Silvio; Berti, Ferruccio] Univ Milan, Dipartimento Farmacol Chemioterapia & Tossicol Me, I-20129 Milan, Italy.
   [Tazzari, Valerio; Sparatore, Anna] Univ Milan, Dipartimento Sci Farmaceut Pietro Pratesi, I-20129 Milan, Italy.
   [Del Soldato, Piero] CTG Pharma, Milan, Italy.
C3 University of Milan; University of Milan
RP Rossoni, G (corresponding author), Univ Milan, Dipartimento Farmacol Chemioterapia & Tossicol Me, Via Vanvitelli 32, I-20129 Milan, Italy.
EM giuseppe.sossoni@unimi.it
RI ; Sparatore, Anna/J-8634-2015
OI MANFREDI, BARBARA/0000-0002-5115-4291; Sparatore,
   Anna/0000-0003-2135-2649
FU CTG Pharma
FX Dr. Piero Del Soldato is a shareholder of CTG Pharma, Milan, Italy. This
   company has patents on reagents used in this study. Professor Anna
   Sparatore received a grant from CTG Pharma.
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NR 29
TC 46
Z9 54
U1 0
U2 13
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0014-2999
EI 1879-0712
J9 EUR J PHARMACOL
JI Eur. J. Pharmacol.
PD DEC 1
PY 2010
VL 648
IS 1-3
BP 139
EP 145
DI 10.1016/j.ejphar.2010.08.039
PG 7
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 673YV
UT WOS:000283701000019
PM 20826133
DA 2025-06-11
ER

PT J
AU Nielsen, FH
AF Nielsen, Forrest H.
TI Magnesium, inflammation, and obesity in chronic disease
SO NUTRITION REVIEWS
LA English
DT Review
DE chronic disease; inflammation; magnesium; obesity; oxidative stress
ID C-REACTIVE PROTEIN; NECROSIS-FACTOR-ALPHA; DIETARY MAGNESIUM; METABOLIC
   SYNDROME; ENDOTHELIAL DYSFUNCTION; INSULIN-RESISTANCE; RECEPTOR
   BLOCKADE; OXIDATIVE STRESS; SERUM MAGNESIUM; TNF-ALPHA
AB About 60% of adults in the United States do not consume the estimated average requirement for magnesium, but widespread pathological conditions attributed to magnesium deficiency have not been reported. Nevertheless, low magnesium status has been associated with numerous pathological conditions characterized as having a chronic inflammatory stress component. In humans, deficient magnesium intakes are mostly marginal to moderate (approximately 50% to < 100% of the recommended dietary allowance). Animal experiments indicate that signs of marginal-to-moderate magnesium deficiency can be compensated or exacerbated by other factors influencing inflammatory and oxidative stress; recent studies suggest a similar happening in humans. This suggestion may have significance in obesity, which is characterized as having a chronic low-grade inflammation component and an increased incidence of a low magnesium status. Marginal-to-moderate magnesium deficiency through exacerbating chronic inflammatory stress may be contributing significantly to the occurrence of chronic diseases such as atherosclerosis, hypertension, osteoporosis, diabetes mellitus, and cancer.
C1 ARS, USDA, Grand Forks Human Nutr Res Ctr, Grand Forks, ND 58202 USA.
C3 United States Department of Agriculture (USDA)
RP Nielsen, FH (corresponding author), ARS, USDA, Grand Forks Human Nutr Res Ctr, 2420 2 Ave N Stop 9034, Grand Forks, ND 58202 USA.
EM forrest.nielsen@ars.usda.gov
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NR 88
TC 209
Z9 232
U1 1
U2 29
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0029-6643
EI 1753-4887
J9 NUTR REV
JI Nutr. Rev.
PD JUN
PY 2010
VL 68
IS 6
BP 333
EP 340
DI 10.1111/j.1753-4887.2010.00293.x
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 603GJ
UT WOS:000278196400002
PM 20536778
DA 2025-06-11
ER

PT J
AU Misiak, B
   Kowalski, K
   Stanczykiewicz, B
   Bartoli, F
   Carrà, G
   Samochowiec, J
   Samochowiec, A
   Frydecka, D
AF Misiak, Blazej
   Kowalski, Krzysztof
   Stanczykiewicz, Bartlomiej
   Bartoli, Francesco
   Carra, Giuseppe
   Samochowiec, Jerzy
   Samochowiec, Agnieszka
   Frydecka, Dorota
TI Appetite-regulating hormones in bipolar disorder: A systematic review
   and meta-analysis
SO FRONTIERS IN NEUROENDOCRINOLOGY
LA English
DT Review
DE Mood disorder; Depression; Adiposity; Obesity; Overweight
ID DRUG-NAIVE PATIENTS; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   PROINFLAMMATORY MARKERS; INFLAMMATORY MARKERS; NEUROTROPHIC FACTOR;
   LEPTIN; ADIPONECTIN; DEPRESSION; DYSFUNCTION
AB Impaired hormonal regulation of appetite may contribute to higher cardiovascular risk in bipolar disorder (BD). We performed a systematic review and meta-analysis of studies investigating peripheral blood levels of appetiteregulating hormones in BD and controls. A total of 32 studies were included. Leptin and insulin levels were significantly elevated in patients with BD during euthymia, but not in other mood states. Greater differences in the number of male participants between patients with BD and healthy controls were associated with higher effect size estimates for the levels of insulin. There were significant positive correlations of effect size estimates for the levels of adiponectin with the percentage of individuals with type I BD and duration of BD. Our findings point to the mechanisms underlying high rates of cardiometabolic comorbidities in BD. Moreover, they suggest that investigating hormonal regulation of appetite might help to understand differences in the neurobiology of BD types.
C1 [Misiak, Blazej; Kowalski, Krzysztof; Stanczykiewicz, Bartlomiej] Wroclaw Med Univ, Dept Psychiat, Div Consultat Psychiat & Neurosci, Pasteura 10 St, PL-50367 Wroclaw, Poland.
   [Bartoli, Francesco; Carra, Giuseppe] Univ Milano Bicocca, Dept Med & Surg, Piazza Ateneo Nuovo 1, I-20126 Monza, Italy.
   [Bartoli, Francesco; Carra, Giuseppe] ASST Nord Milano, Dept Mental Hlth & Addict, Viale Matteotti 83, I-20099 Milan, Italy.
   [Carra, Giuseppe] UCL, Div Psychiat, 149 Tottenham Court Rd, London W1T 7NF, England.
   [Samochowiec, Jerzy] Pomeranian Med Univ, Dept Psychiat, Broniewskiego 26 St, PL-71460 Szczecin, Poland.
   [Samochowiec, Agnieszka] Univ Szczecin, Inst Psychol, Dept Clin Psychol, Krakowska 69 St, PL-71017 Szczecin, Poland.
   [Frydecka, Dorota] Wroclaw Med Univ, Dept & Clin Psychiat, Pasteura 10 St, PL-50367 Wroclaw, Poland.
C3 Wroclaw Medical University; University of Milano-Bicocca; University of
   London; University College London; Pomeranian Medical University;
   University of Szczecin; Wroclaw Medical University
RP Misiak, B (corresponding author), Wroclaw Med Univ, Dept Psychiat, Div Consultat Psychiat & Neurosci, Pasteura 10 St, PL-50367 Wroclaw, Poland.
EM blazej.misiak@umed.wroc.pl
RI Frydecka, Dorota/ABD-8176-2021; Kowalski, Krzysztof/GZG-2552-2022;
   Samochowiec, Jerzy/G-8175-2014; Misiak, Błażej/ABA-2657-2021;
   Stanczykiewicz, Bartlomiej/J-5742-2017; Kowalski,
   Krzysztof/GXH-9273-2022; Carra, Giuseppe/C-6091-2012; Bartoli,
   Francesco/K-5755-2016
OI Stanczykiewicz, Bartlomiej/0000-0001-9221-3502; Kowalski,
   Krzysztof/0000-0002-7145-8284; Carra, Giuseppe/0000-0002-6877-6169;
   /0000-0001-9783-7234; Frydecka, Dorota/0000-0001-8582-9958; Bartoli,
   Francesco/0000-0003-2612-4119; Misiak, Blazej/0000-0002-5392-6398
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NR 99
TC 9
Z9 9
U1 1
U2 33
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0091-3022
EI 1095-6808
J9 FRONT NEUROENDOCRIN
JI Front. Neuroendocrinol.
PD OCT
PY 2022
VL 67
AR 101013
DI 10.1016/j.yfrne.2022.101013
EA JUL 2022
PG 10
WC Endocrinology & Metabolism; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology
GA 4Y7UR
UT WOS:000861729400001
PM 35792198
OA hybrid
DA 2025-06-11
ER

PT J
AU Nie, YW
   Wang, CC
   Yang, L
   Yang, Z
   Sun, YH
   Tian, MZ
   Ma, YH
   Zhang, YX
   Yuan, YM
   Zhang, LP
AF Nie, Yanwu
   Wang, Chenchen
   Yang, Lei
   Yang, Zhen
   Sun, Yahong
   Tian, Maozai
   Ma, Yuhua
   Zhang, Yuxia
   Yuan, Yimu
   Zhang, Liping
TI Relationship Analysis of Inorganic Arsenic Exposure and Metabolic
   Syndrome Based on Propensity Score Matching in Xinjiang, China
SO DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
LA English
DT Article
DE metabolic syndrome; urinary inorganic arsenic; propensity score
   matching; subgroup analysis
ID OXIDATIVE STRESS; HEAVY-METALS; ADULTS; PREVALENCE; ASSOCIATION;
   METHYLATION; DISEASE; MICE
AB Purpose: The role of inorganic arsenic (iAs) in the risk of metabolic syndrome (MetS) remains unclear. This investigation focused on the effect of iAs exposure on MetS and whether the results are consistent in different subgroups. Patients and Methods: The present study was conducted on 629 men and 616 women aged 35-70 years and living in Xinjiang Uygur Autonomous Region, China. The 1:1 propensity score matching (PSM) was adopted to regulate the confounding factors, and the multivariate logistic regression was performed to assess the relationship between urinary iAs and MetS. Results: The median content of urinary iAs was examined as 2.20 mu g/dL (interquartile range: 1.30-3.20 mu g/dL), and the MetS prevalence reached 23.69% (295 cases/950 participants). After the confounding factors were adjusted, the ORs (95% CIs) for MetS from the minimal to the maximum urinary iAs quartiles reached 1.171 (0.736,1.863), 1.568 (1.008, 2.440) and 2.011 (1.296, 3.120), respectively (referencing 1.00) (P for trend=0.001). After the PSM, the urinary iAs content still plays a potential prediction role in MetS (P for trend=0.011). In addition, as revealed from the subgroup analysis, the urinary iAs content was a predictor of MetS in the female patients, whereas it did not serve as a significant predictor of MetS in the male patients (P for interaction<0.05). Conclusion: The increased urinary iAs content was associated with the increased prevalence of MetS in Chinese population. More attention should be paid to female urinary iAs content to avoid the high prevalence of MetS.
C1 [Nie, Yanwu] Xinjiang Med Univ, Sch Publ Hlth, State Key Lab Pathogenesis Prevent & Treatment Hi, Urumqi 830017, Peoples R China.
   [Wang, Chenchen] Ctr Dis Control & Prevent Xinjiang Uygur Autonomo, Urumqi 830017, Peoples R China.
   [Yang, Lei] Xinjiang Med Univ, Sch Nursing, Urumqi 830017, Peoples R China.
   [Yang, Zhen; Sun, Yahong] Xinjiang Med Univ, Sch Publ Hlth, Urumqi 830017, Peoples R China.
   [Tian, Maozai] Renmin Univ China, Ctr Appl Stat, Sch Stat, Beijing 100872, Peoples R China.
   [Tian, Maozai; Zhang, Liping] Xinjiang Med Univ, Coll Med Engn & Technol, Urumqi 830017, Peoples R China.
   [Ma, Yuhua] Tongji Univ, Shanghai East Hosp, Dept Oncol, Sch Med, Shanghai 200120, Peoples R China.
   [Ma, Yuhua] Karamay Cent Hosp XinJiang Karamay, Dept Pathol, Karamay 834000, Xinjiang Uygur, Peoples R China.
   [Zhang, Yuxia] Urumqi Maternal & Child Hlth Inst, Dept Clin Nutr, Urumqi 830001, Peoples R China.
   [Yuan, Yimu] Xinjiang Corps Hosp, Dept Gen Practice Med, Urumqi, Peoples R China.
C3 Xinjiang Medical University; Xinjiang Medical University; Xinjiang
   Medical University; Renmin University of China; Xinjiang Medical
   University; Tongji University
RP Zhang, LP (corresponding author), Xinjiang Med Univ, Coll Med Engn & Technol, Urumqi 830017, Peoples R China.
EM zhanglp1219@163.com
RI Wang, Hengliang/AAT-4586-2021
FU State Key Laboratory of Pathogenesis, Prevention and Treatment of High
   Incidence Diseases in Central Asia Fund [SKL-HIDCA-2020-9]; National
   Natural Science Foundation of China [72163033, 72064036, 72174175];
   Natural science funding of Xinjiang Uygur Autonomous Region, China
   [2021D01A21]
FX This work was funded by State Key Laboratory of Pathogenesis, Prevention
   and Treatment of High Incidence Diseases in Central Asia Fund
   (SKL-HIDCA-2020-9) , National Natural Science Foundation of China
   (GrantNo. 72163033, 72064036, 72174175) and the Natural science funding
   of Xinjiang Uygur Autonomous Region (2021D01A21) , China.
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NR 55
TC 3
Z9 3
U1 0
U2 18
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-7007
J9 DIABET METAB SYND OB
JI Diabetes Metab. Syndr. Obes.
PY 2022
VL 15
BP 921
EP 931
DI 10.2147/DMSO.S349583
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 0G9QA
UT WOS:000778373900004
PM 35370411
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Vasmehjani, AA
   Darabi, Z
   Nadjarzadeh, A
   Mirzaei, M
   Hosseinzadeh, M
AF Vasmehjani, Azam Ahmadi
   Darabi, Zahra
   Nadjarzadeh, Azadeh
   Mirzaei, Masoud
   Hosseinzadeh, Mahdieh
TI The relation between dietary phytochemical index and metabolic syndrome
   and its components in a large sample of Iranian adults: a
   population-based study
SO BMC PUBLIC HEALTH
LA English
DT Article
DE Dietary phytochemical index; Metabolic syndrome; Phytochemical-rich
   foods; Triglyceride; Hypertension; Iran
ID 3-YEAR FOLLOW-UP; OXIDATIVE STRESS; BLOOD-PRESSURE; ATHEROSCLEROSIS
   RISK; INSULIN-RESISTANCE; KOREAN WOMEN; VITAMIN-C; HYPERTENSION; FRUIT;
   ASSOCIATION
AB Background Despite the protective effects of foods being rich in phytochemicals against chronic diseases, this issue is still poorly understood. The aim of this study was to investigate the association between Dietary Phytochemical Index (DPI) and metabolic syndrome (MetS) and its components. Methods This cross-sectional study focused on adults aged between 20 and 70years. The dietary intake was assessed using a validated and reliable food frequency questionnaire. DPI was calculated based on dietary energy, derived from phytochemical-rich food sources (kcal) per total daily energy intake (kcal). The odds ratio of MetS and its components were assessed across DPI quartiles by logistic regression models. Results After adjustment for all potential confounders, the risk of MetS (OR: 0.63, 95% CI = 0.41-0.96) and elevated blood pressure (OR: 0.62, 95% CI = 0.40-0.96) in the second category of DPI decreased significantly as compared to that in the first category. Subjects in the second and fourth quartiles of DPI with adjusting for age, sex and total energy intake revealed 30 and 25% lower risk of abdominal obesity, respectively. After full adjustment for confounders, the analysis stratified by sex showed women in the highest quartile of DPI had 59% lower risk of MetS (OR: 0.41, 95% CI = 0.22-0.76) as compared to those in the lowest quartile of DPI. Conclusions Greater adherence to phytochemical-rich diet could reduce odds of MetS and some components, especially in women. Further studies with intervention approaches are recommended.
C1 [Vasmehjani, Azam Ahmadi; Darabi, Zahra; Nadjarzadeh, Azadeh; Hosseinzadeh, Mahdieh] Shahid Sadoughi Univ Med Sci, Sch Publ Hlth, Nutr & Food Secur Res Ctr, Yazd, Iran.
   [Vasmehjani, Azam Ahmadi; Darabi, Zahra; Nadjarzadeh, Azadeh; Hosseinzadeh, Mahdieh] Shahid Sadughi Univ Med Sci, Dept Nutr, Sch Publ Hlth, Yazd, Iran.
   [Mirzaei, Masoud] Shahid Sadoughi Univ Med Sci, Yazd Cardiovasc Res Ctr, Yazd, Iran.
C3 Shahid Sadoughi University of Medical Sciences; Shahid Sadoughi
   University of Medical Sciences
RP Hosseinzadeh, M (corresponding author), Shahid Sadoughi Univ Med Sci, Sch Publ Hlth, Nutr & Food Secur Res Ctr, Yazd, Iran.; Hosseinzadeh, M (corresponding author), Shahid Sadughi Univ Med Sci, Dept Nutr, Sch Publ Hlth, Yazd, Iran.
EM hoseinzade.mahdie@gmail.com
RI Mirzaei, Masoud/JVM-7958-2024; Nadjarzadeh, Azadeh/A-8490-2017
OI Mirzaei, Masoud/0000-0001-6455-0747
FU Nutrition and Food Security Research Center, Shahid Sadoughi University
   of Medical Sciences, Yazd, Iran
FX This research was funded by Nutrition and Food Security Research Center,
   Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
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NR 56
TC 16
Z9 16
U1 1
U2 4
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2458
J9 BMC PUBLIC HEALTH
JI BMC Public Health
PD AUG 24
PY 2021
VL 21
IS 1
AR 1587
DI 10.1186/s12889-021-11590-2
PG 10
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA UE6OT
UT WOS:000688005800001
PM 34429094
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Millar, CL
   Duclos, Q
   Garcia, C
   Norris, GH
   Lemos, BS
   DiMarco, DM
   Fernandez, ML
   Blesso, CN
AF Millar, Courtney L.
   Duclos, Quinn
   Garcia, Chelsea
   Norris, Gregory H.
   Lemos, Bruno S.
   DiMarco, Diana M.
   Fernandez, Maria Luz
   Blesso, Christopher N.
TI Effects of Freeze-Dried Grape Powder on High-Density Lipoprotein
   Function in Adults with Metabolic Syndrome: A Randomized Controlled
   Pilot Study
SO METABOLIC SYNDROME AND RELATED DISORDERS
LA English
DT Article
DE grape; HDL; PON1; metabolic syndrome; polyphenols
ID CHOLESTEROL EFFLUX CAPACITY; APOLIPOPROTEIN-A-I; CARDIOVASCULAR-DISEASE;
   SERUM PARAOXONASE; OXIDATIVE STRESS; RICH EXTRACT; HDL; ATHEROSCLEROSIS;
   ACCUMULATION; INHIBITION
AB Background: High-density lipoprotein (HDL) particles are protective against atherosclerosis. However, HDL function is impaired in metabolic syndrome (MetS) due to low-grade inflammation and dyslipidemia. Foods containing polyphenols, such as grapes, may prevent HDL dysfunction via antioxidant or anti-inflammatory effects. We evaluated the effects of grape powder ingestion on measures of HDL function in adults with MetS. Methods: Twenty adults (age: 32-70 years; body mass index: 25.3-45.4kg/m(2)) consumed either 60 grams/day of freeze-dried grape powder (GRAPE) or a placebo for 4 weeks, separated by a 3-week washout period, in a randomized, double-blind crossover study. The primary outcome was serum paraoxonase-1 (PON1) arylesterase activity, a measure of HDL antioxidant function. Secondary outcomes included PON1 lactonase activity, plasma lipids, metabolic markers, cholesterol efflux capacity, and other HDL functional markers. Results: After 4 weeks, GRAPE did not alter the serum PON1 activity or other markers of HDL function compared with placebo. Measures of HDL function were positively correlated with each other and inversely with measures of insulin resistance and inflammation. GRAPE intake led to a significant reduction in fasting plasma triglycerides compared with placebo (P=0.032). No other significant effects of GRAPE were observed for other plasma lipids, anthropometrics, or metabolic measures. Conclusions: Grape powder consumption did not impact HDL function in this cohort of adults with MetS. However, it was shown to improve fasting triglycerides, a risk factor for cardiovascular disease.
C1 [Millar, Courtney L.; Duclos, Quinn; Garcia, Chelsea; Norris, Gregory H.; Lemos, Bruno S.; DiMarco, Diana M.; Fernandez, Maria Luz; Blesso, Christopher N.] Univ Connecticut, Dept Nutr Sci, 3624 Horsebarn Rd Ext,U-4017, Storrs, CT 06269 USA.
C3 University of Connecticut
RP Blesso, CN (corresponding author), Univ Connecticut, Dept Nutr Sci, 3624 Horsebarn Rd Ext,U-4017, Storrs, CT 06269 USA.
EM christopher.blesso@uconn.edu
RI Blesso, Christopher/N-9495-2014
OI Lemos, Bruno/0000-0002-3859-6175; Garcia, Chelsea/0000-0002-7681-695X
FU California Table Grape Commission
FX This work was supported by an award to C.N.B. from the California Table
   Grape Commission. This trial is registered at clinicaltrials.gov, trial
   number NCT02542176.
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NR 43
TC 18
Z9 21
U1 0
U2 18
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-4196
EI 1557-8518
J9 METAB SYNDR RELAT D
JI Metab. Syndr. Relat. Disord.
PD NOV
PY 2018
VL 16
IS 9
BP 464
EP 469
DI 10.1089/met.2018.0052
PG 6
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA GY9BQ
UT WOS:000448934400002
PM 30129815
DA 2025-06-11
ER

PT J
AU Akboga, MK
   Canpolat, U
   Yuksel, M
   Yayla, C
   Yilmaz, S
   Turak, O
   Ozeke, O
   Topaloglu, S
   Aras, D
AF Akboga, Mehmet Kadri
   Canpolat, Ugur
   Yuksel, Murat
   Yayla, Cagri
   Yilmaz, Samet
   Turak, Osman
   Ozeke, Ozcan
   Topaloglu, Serkan
   Aras, Dursun
TI Platelet to lymphocyte ratio as a novel indicator of inflammation is
   correlated with the severity of metabolic syndrome: A single center
   large-scale study
SO PLATELETS
LA English
DT Article
DE C-reactive protein; inflammation; metabolic syndrome; platelet to
   lymphocyte ratio
ID C-REACTIVE PROTEIN; CARDIOVASCULAR-DISEASE; INSULIN-RESISTANCE; RISK;
   ATHEROSCLEROSIS; ASSOCIATION; DYSFUNCTION; COMPONENTS; PREDICTOR;
   MORTALITY
AB Metabolic syndrome (MetS) as a cluster of several cardio-metabolic components is rapidly growing public-health problem worldwide and significantly associated with poor cardiovascular outcomes. Increased visceral adiposity activates the important pathways connecting low-grade chronic inflammation, oxidative stress and blood coagulation. Recently, platelet to lymphocyte ratio (PLR) has been evidenced as a novel indirect inflammatory marker. Therefore, for the first time, we aimed to investigate the association of PLR with both the presence and severity of MetS. In this cross-sectional study, a total of 1146 participants were enrolled (n=539 with MetS and n=607 without MetS). MetS was defined according to NCEP-ATP III criteria. MetS (+) group revealed significantly higher PLR and C-reactive protein (CRP) levels as compared to MetS (-) group (p<0.05). There was a graded relationship between increasing number of MetS components and PLR (p<0.05). Also, PLR was positively correlated with CRP level (r=0.163, p<0.001). In multivariate regression analysis, PLR [1.121 (1.113-1.135), p<0.001], CRP [1.044 (1.029-1.060), p<0.001], and age [1.030 (1.017-1.043), p<0.001] were remained as independent predictors for the presence of MetS. In conclusion, our findings showed that increased PLR was significantly associated with both the presence and severity of MetS which was linked to systemic inflammation based on the correlation between PLR and CRP. As PLR is an easily available, simple and cheap indirect indicator of inflammation, it can be used in clinical practice as a predictor of MetS.
C1 [Akboga, Mehmet Kadri; Canpolat, Ugur; Yayla, Cagri; Yilmaz, Samet; Turak, Osman; Ozeke, Ozcan; Topaloglu, Serkan; Aras, Dursun] Turkiye Yuksek Ihtisas Training & Res Hosp, Cardiol Clin, Ankara, Turkey.
   [Yuksel, Murat] Dicle Univ, Fac Med, Dept Cardiol, Diyarbakir, Turkey.
C3 Turkey Specialized Higher Education & Research Hospital; Dicle
   University
RP Akboga, MK (corresponding author), Turkiye Yuksek Ihtisas Training & Res Hosp, Cardiol Clin, Cardiol, Ankara, Turkey.
EM mkakboga@yahoo.com
RI Yılmaz, Samet/Q-5077-2016; Özeke, Özcan/N-1871-2015; Yuksel,
   Murat/B-7287-2013; Akboga, Mehmet/AAS-8818-2020; Ozeke,
   Ozcan/AAS-8730-2020; Canpolat, Ugur/S-3482-2018; YAYLA,
   CAGRI/B-9270-2019
OI Ozeke, Ozcan/0000-0002-4770-8159; Canpolat, Ugur/0000-0002-4250-1706;
   YAYLA, CAGRI/0000-0002-5302-4052
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NR 35
TC 57
Z9 61
U1 0
U2 9
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 0953-7104
EI 1369-1635
J9 PLATELETS
JI Platelets
PD FEB 17
PY 2016
VL 27
IS 2
BP 178
EP 183
DI 10.3109/09537104.2015.1064518
PG 6
WC Cell Biology; Hematology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Hematology
GA DF9ZF
UT WOS:000371720500013
PM 26196312
DA 2025-06-11
ER

PT J
AU Shivpuri, S
   Allison, MA
   Macera, CA
   Lindsay, S
   Gallo, LC
AF Shivpuri, Smriti
   Allison, Matthew A.
   Macera, Caroline A.
   Lindsay, Suzanne
   Gallo, Linda C.
TI Associations Between Nocturnal Blood Pressure Dipping and the Metabolic
   Syndrome in High- Vs. Low-Acculturated Mexican American Women
SO AMERICAN JOURNAL OF HYPERTENSION
LA English
DT Article
DE acculturation; blood pressure; blood pressure dipping; Hispanic;
   hypertension; metabolic syndrome
ID HYPERTENSIVE PATIENTS; SYNDROME SCORE; PHYSICAL-ACTIVITY; PROFILE;
   STRESS; HEALTH; FALL; US; PATTERN; EVENTS
AB BACKGROUND
   Less nocturnal blood pressure (BP) dipping has been associated with greater odds for the metabolic syndrome (MetS), a constellation of risk factors associated with cardiovascular disease (CVD). Little work has examined this association in Hispanics, who have elevated rates of MetS, or investigated differences in this relationship by level of acculturation. The purpose of this study was to examine the association between BP dipping and MetS in Hispanic women and to determine if this association is moderated by acculturation status.
   METHODS
   Two hundred eighty-six Mexican American women underwent assessment of MetS components (BP, waist circumference, fasting glucose, high-density lipoprotein cholesterol, and triglycerides) and completed a 36-hour ambulatory BP monitoring protocol, during which systolic BP (SBP) and diastolic BP readings were obtained. Nocturnal BP dipping was calculated as the percentage difference between average daytime and nighttime BP. Acculturation was defined by the language (Spanish, English) in which participants preferred to complete study instruments.
   RESULTS
   Although no significant main effects for BP dipping or acculturation emerged for MetS, the SBP dipping by acculturation interaction was significantly related to MetS (P < 0.01). Simple slope analyses revealed that less SBP dipping related to greater odds of MetS in high-acculturated women, but SBP dipping and MetS were unrelated in low-acculturated women.
   CONCLUSIONS
   The strength of the association between BP dipping and CVD risk (as measured by MetS) appears to vary by acculturation in Hispanic women. Future studies should explore mechanisms behind the BP dipping and CVD risk association and relevant modifying factors.
C1 [Shivpuri, Smriti] Univ Calif San Diego, San Diego State Univ, Joint Doctoral Program Clin Psychol, San Diego, CA 92103 USA.
   [Allison, Matthew A.] Univ Calif San Diego, Dept Family & Prevent Med, San Diego, CA 92103 USA.
   [Macera, Caroline A.; Lindsay, Suzanne] San Diego State Univ, Grad Sch Publ Hlth, San Diego, CA 92182 USA.
   [Gallo, Linda C.] San Diego State Univ, Dept Psychol, San Diego, CA 92182 USA.
C3 California State University System; San Diego State University;
   University of California System; University of California San Diego;
   University of California System; University of California San Diego;
   California State University System; San Diego State University;
   California State University System; San Diego State University
RP Shivpuri, S (corresponding author), Univ Calif San Diego, San Diego State Univ, Joint Doctoral Program Clin Psychol, San Diego, CA 92103 USA.
EM smriti.shivpuri@gmail.com
OI Allison, Matthew/0000-0003-0777-8272; Gallo, Linda
   C./0000-0002-3678-5888
FU National Heart Lung and Blood Institute, National Institutes of Health
   (NHLBI/NIH) [1R01HL081604, 1T32HL079891]
FX This work was supported by grants from the National Heart Lung and Blood
   Institute, National Institutes of Health (NHLBI/NIH) (1R01HL081604;
   1T32HL079891 to SS).
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NR 46
TC 3
Z9 4
U1 0
U2 5
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0895-7061
EI 1941-7225
J9 AM J HYPERTENS
JI Am. J. Hypertens.
PD AUG
PY 2013
VL 26
IS 8
BP 1030
EP 1036
DI 10.1093/ajh/hpt061
PG 7
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Cardiovascular System & Cardiology
GA 182CO
UT WOS:000321718300013
PM 23645325
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Lutgers, HL
   Graaff, R
   de Vries, R
   Smit, AJ
   Dullaart, RPF
AF Lutgers, Helen L.
   Graaff, Reindert
   de Vries, Rindert
   Smit, Andries J.
   Dullaart, Robin P. F.
TI Carotid artery intima media thickness associates with skin
   autofluoresence in non-diabetic subjects without clinically manifest
   cardiovascular disease
SO EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
LA English
DT Article
DE Intima media thickness; lipoproteins; metabolic syndrome;
   paraoxoanase-1; skin autofluorescence
ID GLYCATION END-PRODUCTS; TYPE-2 DIABETES-MELLITUS; C-REACTIVE PROTEIN;
   METABOLIC SYNDROME; MYOCARDIAL-INFARCTION; DENSITY-LIPOPROTEIN;
   OXIDATIVE STRESS; RISK; COMPLICATIONS; ACCUMULATION
AB P>Background
   Skin autofluorescence (skin AF) is determined in part by accumulation of advanced glycation end products. Increased skin AF was shown previously to predict cardiovascular events independently of conventional risk factors. We determined the association of carotid artery intima media thickness (IMT), a marker of subclinical cardiovascular disease, with skin AF in subjects without diabetes or clinically manifest cardiovascular disease.
   Methods
   In a cross-sectional observational study, IMT, skin AF, lipids and apolipoproteins, C-reactive protein (CRP), insulin resistance and paraoxonase-1 activity were measured in 59 non-smoking, non-obese subjects without diabetes mellitus and cardiovascular disease (32 women; 12 subjects with metabolic syndrome (MetS)).
   Results
   In univariate analyses, skin AF was correlated with IMT (r = 0 center dot 265, P = 0 center dot 042), but not significantly with clinical factors, (apo)lipoproteins, CRP, insulin resistance and paraoxonase-1. In multiple linear regression analyses, IMT was determined independently by age (beta = 0 center dot 549, P < 0 center dot 001), apo B (beta = 0 center dot 236, P = 0 center dot 022) and skin AF (beta = 0 center dot 216, P = 0 center dot 035). IMT was also associated with skin AF (beta = 0 center dot 213, P = 0 center dot 046) in a model which included the presence of MetS.
   Conclusions
   IMT is positively related to skin AF, independently of clinical factors, (apo)lipoproteins and MetS, suggesting that skin AF represents a determinant of subclinical atherosclerosis. Increased skin AF may reflect early abnormalities in processes involved in atherosclerosis development.
C1 [Lutgers, Helen L.; de Vries, Rindert; Dullaart, Robin P. F.] Univ Med Ctr Groningen, Dept Endocrinol & Metab, NL-9700 RB Groningen, Netherlands.
   [Graaff, Reindert] Univ Med Ctr Groningen, Dept Biomed Engn, NL-9700 RB Groningen, Netherlands.
   [Smit, Andries J.] Univ Med Ctr Groningen, Dept Internal Med, NL-9700 RB Groningen, Netherlands.
   [Smit, Andries J.] Univ Groningen, NL-9700 RB Groningen, Netherlands.
C3 University of Groningen; University of Groningen; University of
   Groningen; University of Groningen
RP Lutgers, HL (corresponding author), Univ Med Ctr Groningen, Dept Endocrinol & Metab, POB 30001, NL-9700 RB Groningen, Netherlands.
EM h.l.lutgers@int.umcg.nl
RI Lutgers, Helen/MFK-2548-2025; Graaff, Reindert/G-8941-2011
FU Dutch Diabetes Research Foundation [2001.00.012]
FX This study is in part supported by grant 2001.00.012 from the Dutch
   Diabetes Research Foundation. Plasma lipid and apo-lipoproteins were
   determined in the laboratory of Dr. L.D. Dikkeschei, Ph.D., Laboratory
   of Clinical Chemistry, Isala Clinics, Zwolle. Serum paraoxonase-1
   activity was measured by Dr. H.A.M. Voorbij, Laboratory of Clinical
   Chemistry and Hematology, University Medical Centre, Utrecht, The
   Netherlands.
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NR 30
TC 37
Z9 39
U1 0
U2 4
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0014-2972
J9 EUR J CLIN INVEST
JI Eur. J. Clin. Invest.
PD SEP
PY 2010
VL 40
IS 9
BP 812
EP 817
DI 10.1111/j.1365-2362.2010.02329.x
PG 6
WC Medicine, General & Internal; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Research & Experimental Medicine
GA 635PS
UT WOS:000280669100006
PM 20597962
DA 2025-06-11
ER

PT J
AU Karatsoreos, IN
AF Karatsoreos, Ilia N.
TI Effects of Circadian Disruption on Mental and Physical Health
SO CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS
LA English
DT Review
DE Biological rhythms; Sleep; Aging; Obesity; Metabolic syndrome;
   Plasticity; Prefrontal; Hippocampus; Learning; Depression; Circadian
   disruption
ID SHIFT WORK; WEIGHT-GAIN; LIGHT; RHYTHMS; NIGHT; CONSEQUENCES;
   DEPRESSION; DISORDER; CLOCKS; BRAIN
AB Circadian (daily) rhythms in physiology and behavior are phylogenetically ancient and are present in almost all plants and animals. In mammals, these rhythms are generated by a master circadian clock in the suprachiasmatic nucleus of the hypothalamus, which in turn synchronizes "peripheral oscillators" throughout the brain and body in almost all cell types and organ systems. Although circadian rhythms are phylogenetically ancient, modern industrialized society and the ubiquity of electric lighting has resulted in a fundamental alteration in the relationship between an individual's endogenous circadian rhythmicity and the external environment. The ramifications of this desynchronization for mental and physical health are not fully understood, although numerous lines of evidence are emerging that link defects in circadian timing with negative health outcomes. This article explores the function of the circadian system, the effects of disrupted clocks on the brain and body, and how these effects impact mental and physical health.
C1 Washington State Univ, Dept Vet & Comparat Anat Pharmacol & Physiol, Pullman, WA 99164 USA.
C3 Washington State University
RP Karatsoreos, IN (corresponding author), Washington State Univ, Dept Vet & Comparat Anat Pharmacol & Physiol, 205 Wegner Hall, Pullman, WA 99164 USA.
EM iliak@vetmed.wsu.edu
RI Karatsoreos, Ilia/AAR-8774-2020
FU Canadian Institute of Health Research
FX Conflicts of interest: I.N. Karatsoreos: has received grant support from
   the Canadian Institute of Health Research.
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NR 40
TC 58
Z9 71
U1 1
U2 45
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1528-4042
EI 1534-6293
J9 CURR NEUROL NEUROSCI
JI Curr. Neurol. Neurosci. Rep.
PD APR
PY 2012
VL 12
IS 2
BP 218
EP 225
DI 10.1007/s11910-012-0252-0
PG 8
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 912KR
UT WOS:000301797400013
PM 22322663
DA 2025-06-11
ER

PT J
AU Gangopadhyay, A
   Ibrahim, R
   Theberge, K
   May, M
   Houseknecht, KL
AF Gangopadhyay, Anwesha
   Ibrahim, Radwa
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   May, Meghan
   Houseknecht, Karen L. L.
TI Non-alcoholic fatty liver disease (NAFLD) and mental illness: Mechanisms
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SO FRONTIERS IN NEUROSCIENCE
LA English
DT Review
DE metabolic liver disease; antipsychotic; insulin resistance;
   inflammation; schizophrenia; depression; obesity; ferroptosis
ID C-REACTIVE PROTEIN; MAJOR DEPRESSIVE DISORDER; TRABECULAR BONE LOSS;
   INSULIN-RESISTANCE; ATYPICAL ANTIPSYCHOTICS; CARDIOVASCULAR-DISEASE;
   HEPATIC STEATOSIS; BIPOLAR DISORDER; NERVOUS-SYSTEM; IRON OVERLOAD
AB Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in the world and one of the leading indications for liver transplantation. It is one of the many manifestations of insulin resistance and metabolic syndrome as well as an independent risk factor for cardiovascular disease. There is growing evidence linking the incidence of NAFLD with psychiatric illnesses such as schizophrenia, bipolar disorder and depression mechanistically via genetic, metabolic, inflammatory and environmental factors including smoking and psychiatric medications. Indeed, patients prescribed antipsychotic medications, regardless of diagnosis, have higher incidence of NAFLD than population norms. The mechanistic pharmacology of antipsychotic-associated NAFLD is beginning to emerge. In this review, we aim to discuss the pathophysiology of NAFLD including its risk factors, insulin resistance and systemic inflammation as well as its intersection with psychiatric illnesses.
C1 [Gangopadhyay, Anwesha; Ibrahim, Radwa; Theberge, Karli; May, Meghan; Houseknecht, Karen L. L.] Univ New England, Coll Osteopath Med, Dept Biomed Sci, Biddeford, ME 04005 USA.
C3 University of New England - Maine
RP Houseknecht, KL (corresponding author), Univ New England, Coll Osteopath Med, Dept Biomed Sci, Biddeford, ME 04005 USA.
EM khouseknecht@une.edu
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NR 315
TC 14
Z9 14
U1 1
U2 14
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1662-453X
J9 FRONT NEUROSCI-SWITZ
JI Front. Neurosci.
PD NOV 15
PY 2022
VL 16
AR 1042442
DI 10.3389/fnins.2022.1042442
PG 24
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 6Q3DQ
UT WOS:000891495600001
PM 36458039
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Filia, SL
   Baker, AL
   Kulkarni, J
   Williams, JM
AF Filia, Sacha L.
   Baker, Amanda L.
   Kulkarni, Jayashri
   Williams, Jill M.
TI Sequential behavioral treatment of smoking and weight control in bipolar
   disorder
SO TRANSLATIONAL BEHAVIORAL MEDICINE
LA English
DT Article
DE Smoking; Smoking cessation; Bipolar disorder; Sequential behavioral
   treatment; Weight gain; Physical activity
ID RANDOMIZED CONTROLLED-TRIAL; HEART-DISEASE RISK; SEVERE MENTAL-ILLNESS;
   SUBSTANCE USE; TOBACCO DEPENDENCE; PSYCHOTIC DISORDER; METABOLIC
   SYNDROME; MOOD DISORDERS; CESSATION; PEOPLE
AB People with severe mental illnesses like schizophrenia and bipolar disorder (BPAD) live significantly shorter lives than people in the general population and most commonly die of cardiovascular disease (CVD). CVD risk behaviors such as smoking are not routinely assessed or assertively treated among people with a severe mental illness. This article provides an illustrative case example of a woman with BPAD who is motivated to quit smoking, despite concerns about weight gain and relapse to depression. It outlines key considerations and describes the patient's experience of participating in a behavioral intervention focussing first on smoking, then diet and physical activity. Clinical challenges encountered during treatment are discussed in the context of relevant literature. These include motivational issues, relapse to depression, medication interactions, weight gain, addressing multiple health behavior change, focussing on a behavioral rather than cognitive approach, collaborating with other health care providers, and gender issues.
C1 [Filia, Sacha L.; Kulkarni, Jayashri] Monash Univ, Monash Alfred Psychiat Res Ctr, Alfred Hosp, Prahran, Vic 3181, Australia.
   [Baker, Amanda L.] Univ Newcastle, Ctr Brain & Mental Hlth Res, Newcastle, NSW 2300, Australia.
   [Williams, Jill M.] UMDNJ Robert Wood Johnson Med Sch, Div Addict Psychiat, New Brunswick, NJ USA.
C3 Florey Institute of Neuroscience & Mental Health; Howard Florey
   Institute Affiliates; Monash University; University of Newcastle;
   Rutgers University System; Rutgers University New Brunswick; Rutgers
   University Biomedical & Health Sciences
RP Filia, SL (corresponding author), Monash Univ, Monash Alfred Psychiat Res Ctr, Alfred Hosp, Level 1,Old Baker Bldg,POB 315, Prahran, Vic 3181, Australia.
EM s.filia@alfred.org.au
RI Baker, Amanda/H-2966-2014
OI Filia, Sacha/0009-0001-1335-0216; Baker, Amanda L./0000-0002-3328-7146
FU Australian National Health and Medical Research Council (NHMRC)
FX Funding for the randomized controlled smoking cessation trial was
   provided by the Australian National Health and Medical Research Council
   (NHMRC), while GlaxoSmithKline provided NRT for the study. Thank you to
   Dr. Kate Hoy and Dr. Stuart Lee for support in preparation of this
   manuscript.
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NR 62
TC 7
Z9 7
U1 0
U2 4
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1869-6716
EI 1613-9860
J9 TRANSL BEHAV MED
JI Transl. Behav. Med.
PD SEP
PY 2012
VL 2
IS 3
BP 290
EP 295
DI 10.1007/s13142-012-0111-1
PG 6
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA V39LM
UT WOS:000209412500009
PM 24073127
OA Green Published
DA 2025-06-11
ER

PT J
AU Abboud, M
   Haidar, S
   Mahboub, N
   Mamo, T
   Papandreou, D
   Rizk, R
AF Abboud, Myriam
   Haidar, Suzan
   Mahboub, Nadine
   Mamo, Tracy
   Papandreou, Dimitrios
   Rizk, Rana
TI Association between the metabolic syndrome and the irritable bowel
   syndrome: a cross-sectional study among a sample of Lebanese adults
SO BRITISH JOURNAL OF NUTRITION
LA English
DT Article; Early Access
DE Metabolic Syndrome; Irritable Bowel Syndrome; Lebanon; Adults
ID SLEEP QUALITY INDEX; PERCEIVED STRESS; DEFINITION; PREVALENCE;
   EPIDEMIOLOGY; AXIS
AB Evidence of an association between metabolic syndrome (MetS) and irritable bowel syndrome (IBS) is emerging but is still inconclusive. The current cross-sectional study was conducted to explore the relationship between the two syndromes in a sample of Lebanese adults (n 221; mean age: 43<middle dot>36 years; 62<middle dot>9 % females), recruited from a large urban university and its neighbouring community. MetS was diagnosed based on the International Diabetes Federation criteria, and IBS was assessed using the Birmingham IBS scale. Logistic regression analyses were performed taking MetS and its components as dependent variables and IBS and its subscales as independent variables. Covariates included socio-demographic, dietary and lifestyle variables. MetS was positively associated with visual analogue scale (VAS) IBS (total scale (Beta = 4<middle dot>59, P = 0<middle dot>029) and VAS-diarrhoea subscale (Beta = 4<middle dot>96, P = 0<middle dot>008). Elevated blood pressure (Beta = 5<middle dot>02, P = 0<middle dot>007), elevated fasting blood sugar (Beta = 4<middle dot>19, P = 0<middle dot>033) and elevated waist circumference (Beta = 5<middle dot>38, P = 0<middle dot>010) were positively associated with VAS-Diarrhoea subscale. MetS and IBS were found to be positively associated in a sample of the Lebanese adult population. We suggest that it might be of value to screen for either condition if one of the syndromes exists. Future longitudinal studies are essential to establish a causal relationship between the two syndromes to further understand the commonality related to pathogenesis and explore potential underlying mechanisms.
C1 [Abboud, Myriam] Zayed Univ, Coll Nat & Hlth Sci, Dubai, U Arab Emirates.
   [Haidar, Suzan; Mahboub, Nadine] Lebanese Int Univ, Dept Nutr & Food Sci, Beirut, Lebanon.
   [Mamo, Tracy; Rizk, Rana] Lebanese Amer Univ, Dept Nat Sci, Byblos, Lebanon.
   [Papandreou, Dimitrios] Univ Sharjah, Dept Clin Nutr & Dietet, CHS, Sharjah, U Arab Emirates.
   [Rizk, Rana] Inst Natl Sante Publ Epidemiol Clin & Toxicol INSP, Beirut, Lebanon.
C3 Zayed University; Lebanese American University; University of Sharjah
RP Haidar, S (corresponding author), Lebanese Int Univ, Dept Nutr & Food Sci, Beirut, Lebanon.
EM suzan.haidar@liu.edu.lb
RI Haidar, Suzan/AAC-6895-2020; Rizk, Rana/KLZ-6274-2024
OI Rizk, Rana/0000-0002-8850-6502
FU RIF Grant [R18030]
FX This research was funded the RIF Grant R18030.
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NR 68
TC 0
Z9 0
U1 1
U2 1
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1145
EI 1475-2662
J9 BRIT J NUTR
JI Br. J. Nutr.
PD 2025 MAR 28
PY 2025
DI 10.1017/S0007114525000650
EA MAR 2025
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 1XH9F
UT WOS:001475865300001
PM 40152006
DA 2025-06-11
ER

PT J
AU Vasudevan, SK
   Seetharam, S
   Dohnalek, MH
   Cartwright, EJ
AF Vasudevan, Subbu Kesavaraja
   Seetharam, Suresh
   Dohnalek, Margaret H.
   Cartwright, Elizabeth J.
TI Spirulina: A daily support to our immune system
SO INTERNATIONAL JOURNAL OF NONCOMMUNICABLE DISEASES
LA English
DT Article
DE Algal proteins; amino acids; antioxidants; Arthrospira platensis;
   bioactive; chronic disease; digestion; gut health; immune system;
   metabolic syndrome; microbiome; peptides; spirulina
ID HERPES-SIMPLEX VIRUS; C-PHYCOCYANIN; ANTIOXIDANT; MAXIMA
AB In recent years, the various health benefits of Cyanobacteria microalgae - such as Arthrospira platensis, commonly called Spirulina, an edible blue-green algae - have attracted scientific attention including micro-level examinations of its bioactive components. As a whole food and nutritional supplement, it serves as a plant protein source, which has shown positive effects across a wide range of human health concerns, from malnutrition to metabolic syndrome. Spirulina bioactives, such as essential amino acids, phycocyanin, polysaccharides, carotenoids, and chlorophyll, and essential vitamins and trace minerals, are responsible for its holistic actions against oxidative stress and inflammation, and its antiviral, antibacterial, and immune-modulating effects. Various in vitro, in vivo, and ex vivo experiments have established Spirulina's mechanism of action and its effect on immunity as a proof of concept. The phenolic compounds and extracellular metabolites released from Spirulina whole food after digestion are postulated to strengthen the epithelial lining with antibacterial effects against pathogenic bacteria, adding to its prebiotic effect on the gut microbiota (like Bifidobacterium and Lactobacillus) due to its fiber content. In this study, the digestibility of Spirulina was assessed by the determination of free amino acids and peptide release during the each phase of digestion in a simulated static digestive model system. The hypothesis bridging poor gut health to low-level inflammation and metabolic syndrome, and the potential to address those issues with nutritional supplementation, such as with Spirulina, could also be beneficial in the long run to reduce comorbid illnesses, such as those associated with the currently prevailing coronavirus disease 2019 pandemic.
C1 [Vasudevan, Subbu Kesavaraja] EID Parry Ind Ltd, Dept Med Affairs, Parry Nutraceut, Chennai, Tamil Nadu, India.
   [Seetharam, Suresh] EID Parry Ind Ltd, Dept Res & Dev, Parry Nutraceut, Chennai, Tamil Nadu, India.
   [Dohnalek, Margaret H.; Cartwright, Elizabeth J.] US Nutraceut Inc, Valensa Int, Eustis, FL USA.
RP Vasudevan, SK (corresponding author), EID Parry Ind Ltd, Parry Nutraceut, Chennai, Tamil Nadu, India.
EM subbukv@parry.murugappa.com
RI Cartwright, Elizabeth/AGN-2997-2022
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NR 45
TC 2
Z9 2
U1 6
U2 22
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, Maharashtra, INDIA
SN 2468-8827
EI 2468-8835
J9 INT J NONCOMMUN DIS
JI Int. J. Noncommun. Dis.
PD NOV
PY 2021
VL 6
IS 5
SU S
SI SI
BP 47
EP 54
DI 10.4103/2468-8827.330650
PG 8
WC Public, Environmental & Occupational Health; Medicine, General &
   Internal
WE Emerging Sources Citation Index (ESCI)
SC Public, Environmental & Occupational Health; General & Internal Medicine
GA 4W6BT
UT WOS:000860246200007
OA gold
DA 2025-06-11
ER

PT J
AU Choi, JR
   Park, S
   Kim, SK
   Kim, JY
   Lee, K
   Oh, SS
   Koh, SB
AF Choi, Jung Ran
   Park, Sungjin
   Kim, Sung-Kyung
   Kim, Jae-Yeop
   Lee, Kyungsuk
   Oh, Sung-Soo
   Koh, Sang Baek
TI Mitochondrial DNA content and deletion ratio are associated with
   metabolic syndrome in a general population exposed to pesticide
SO MOLECULAR & CELLULAR TOXICOLOGY
LA English
DT Article
DE mtDNA copy number; Deletion ratio; Metabolic syndrome; Pesticide
   exposure
ID COPY NUMBER; OXIDATIVE STRESS; BIOMARKER; OBESITY; BLOOD
AB Background Mitochondrial DNA (mtDNA) copy number and deletion ratio may be asymmetrically determined using physiologic or pathologic conditions. Mitochondrial dysfunction is associated with an increased risk of developing metabolic syndrome (MetS). Objective Here, we investigated the association between mtDNA copy number and/or deletion ratio and the risk of developing MetS in a general population exposed to the pesticide. We examined 215 randomly sampled adults who were exposed to pesticide but did not present with MetS in a prospective cohort study. Both mtDNA copy number and deletion ratio were determined using quantitative real-time polymerase chain reaction. Results During the average 2.8-year follow-up period, 76 (35.3%) participants developed new-onset MetS. The numbers of mtDNA copies were significantly lower in participants with new-onset MetS than in those without MetS (112.15 +/- 26.15 vs. 133.13 +/- 44.44, p < 0.001), whereas the mtDNA deletion ratios were higher in participants with MetS than in those without MetS (10.59 +/- 11.96 vs. 4.52 +/- 6.74, p < 0.001). In the multivariate-adjusted models, the participants with a higher tertile of mtDNA copy number were 0.355 times more likely to develop MetS than those with the lowest tertile [odds ratio (OR) 0.355, 95% confidence interval (CI) 0.150-0.841, p = 0.004]. A higher mtDNA deletion ratio was significantly associated with the risk of developing MetS in populations exposed to pesticide (OR 5.062, 95% CI 1.164-22.004, p = 0.004). Conclusion A lower mtDNA copy number and higher deletion ratio were independent predictors for new-onset MetS in a general population exposed to the pesticide.
C1 [Choi, Jung Ran; Koh, Sang Baek] Yonsei Univ, Inst Genom Cohort, Wonju Coll Med, Wonju 26426, South Korea.
   [Park, Sungjin] Yonsei Univ, Grad Sch, Seoul, South Korea.
   [Park, Sungjin] Hongseong Med Ctr, Dept Occupat & Environm Med, Hongseong, South Korea.
   [Kim, Sung-Kyung; Kim, Jae-Yeop; Oh, Sung-Soo; Koh, Sang Baek] Yonsei Univ, Wonju Coll Med, Dept Occupat & Environm Med, Wonju, South Korea.
   [Kim, Sung-Kyung; Kim, Jae-Yeop; Oh, Sung-Soo; Koh, Sang Baek] Yonsei Univ, Wonju Coll Med, Dept Prevent Med, Wonju 26426, South Korea.
   [Kim, Sung-Kyung; Kim, Jae-Yeop; Oh, Sung-Soo; Koh, Sang Baek] Yonsei Univ, Wonju Coll Med, Inst Occupat & Environm Med, Wonju 26426, South Korea.
   [Lee, Kyungsuk] Rural Dev Adm, Natl Acad Agr Sci, Jeonju, South Korea.
   [Koh, Sang Baek] Yonsei Univ, Ctr Global Hlth & Social Med, Inst Poverty Alleviat & Int Dev, Wonju, South Korea.
C3 Yonsei University; Yonsei University; Yonsei University; Yonsei
   University; Yonsei University; Rural Development Administration (RDA),
   Republic of Korea; Yonsei University
RP Choi, JR; Koh, SB (corresponding author), Yonsei Univ, Inst Genom Cohort, Wonju Coll Med, Wonju 26426, South Korea.; Koh, SB (corresponding author), Yonsei Univ, Wonju Coll Med, Dept Occupat & Environm Med, Wonju, South Korea.; Koh, SB (corresponding author), Yonsei Univ, Wonju Coll Med, Dept Prevent Med, Wonju 26426, South Korea.; Koh, SB (corresponding author), Yonsei Univ, Wonju Coll Med, Inst Occupat & Environm Med, Wonju 26426, South Korea.; Koh, SB (corresponding author), Yonsei Univ, Ctr Global Hlth & Social Med, Inst Poverty Alleviat & Int Dev, Wonju, South Korea.
EM christinae@yonsei.ac.kr; psjin9318@gmail.com; stacte@yonsei.ac.kr;
   kimjy87330@gmail.com; leeks81@korea.kr; oss0609@yonsei.ac.kr;
   kohhj@yonsei.ac.kr
RI PARK, SUNGJIN/AAJ-3406-2020; Kim, Yongkang/AAC-7436-2020; Kim,
   Sung-Kyung/GLU-8569-2022
OI Kim, Sung-Kyung/0000-0002-2742-6410
FU National Research Foundation of Korea (NRF) - Ministry of Education
   [2017R1D1A3B03034119]; Medical Research Center Program
   [2017R1A5A2015369]; Cooperative Research Program for Agriculture Science
   & Technology Development Rural Development Administration, Republic of
   Korea [PJ01250901]; Yonsei University
FX This research was supported by the Basic Science Research Program
   through the National Research Foundation of Korea (NRF), funded by the
   Ministry of Education (2017R1D1A3B03034119). Moreover, this research was
   supported by the Medical Research Center Program 2017R1A5A2015369. This
   work was carried out with the support of the Cooperative Research
   Program for Agriculture Science & Technology Development (project no.:
   PJ01250901) Rural Development Administration, Republic of Korea. This
   work was supported (in part) by the Yonsei University Research Fund of
   2017.
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NR 25
TC 3
Z9 3
U1 0
U2 4
PU KOREAN SOCIETY TOXICOGENOMICS & TOXICOPROTEOMICS-KSTT
PI GYEONGGI-DO
PA HANYANG UNIV, SCI & TECHNOL BLDG 1, RM 423, SA-DONG, SANGROK-GU, ANSAN,
   GYEONGGI-DO, 426 791, SOUTH KOREA
SN 1738-642X
EI 2092-8467
J9 MOL CELL TOXICOL
JI Mol. Cell. Toxicol.
PD JUL
PY 2020
VL 16
IS 3
BP 347
EP 354
DI 10.1007/s13273-020-00079-5
EA MAR 2020
PG 8
WC Biochemistry & Molecular Biology; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Toxicology
GA MB7ZO
UT WOS:000522925300001
DA 2025-06-11
ER

PT J
AU Pérez, MJ
   Zampini, IC
   Alberto, MR
   Isla, MI
AF Perez, Maria J.
   Zampini, Iris C.
   Alberto, Maria R.
   Isla, Maria I.
TI Prosopis nigra Mesocarp Fine Flour, A Source of Phytochemicals
   with Potential Effect on Enzymes Linked to Metabolic Syndrome, Oxidative
   Stress, and Inflammatory Process
SO JOURNAL OF FOOD SCIENCE
LA English
DT Article
DE bound phenolics; free phenolics; mesocarp flour; metabolic syndrome;
   Prosopis nigra
ID ANTIOXIDANT PROPERTIES; GEOFFROEA-DECORTICANS; PHENOLIC-COMPOUNDS; ALBA
   PODS; FRACTIONS; L.; ANTHOCYANINS; INHIBITORS; PROFILES; CAPACITY
AB This work is part of the search in native food matrices from arid regions of Argentina of interest to improve human health. Prosopis species are ethnic food resources in South America capable of growing in arid and semi-arid environments. This work was focused to determine the nutritional and phytochemical composition of Prosopis nigra fine flour and to evaluate its biological properties. Flour showed a high level of sucrose (30.35 g/100 mu g flour), fiber (6.34 g/100 g flour), polyphenols (0.45 g GAE/100 g flour), and minerals (potassium, calcium, and magnesium). Apigenin C glycosides and phenylpropanoid acids were identified in free and bound phenolic enriched extracts, respectively. Polyphenols (especially free polyphenols) were able to inhibit enzymes associated with the metabolic syndrome, including alpha-amylase (IC50 30.1 mu g GAE/mL), alpha-glucosidase (IC50 22.5 mu g GAE/mL), while bound phenolics may control lipase activity (IC50 33.5 mu g GAE/mL) and exhibit antioxidant activity by different action mechanisms (SC50 between 16 and 93 mu g GAE/mL). Both extracts were more effective to inhibit cyclooxygenase-2 than phospholipase A(2) and lipoxygenase, proinflammatory enzymes. Polyphenolic extracts did not show any mutagenic effect. Our studies add value to this non-conventional flour as a promising food resource that could be used as a functional food or functional ingredient in formulations to reduce the risk of the development of obesity. These studies revalue our native resources by promoting their conservation, their use and their propagation.
C1 [Perez, Maria J.; Zampini, Iris C.; Alberto, Maria R.; Isla, Maria I.] Univ Nacl Tucuman, Fac Ciencias Nat & IML, Inst Bioprospecc & Fisiol Vegetal INBIOFIV CONICE, San Miguel De Tucuman, Argentina.
C3 Universidad Nacional de Tucuman
RP Isla, MI (corresponding author), Univ Nacl Tucuman, Fac Ciencias Nat & IML, Inst Bioprospecc & Fisiol Vegetal INBIOFIV CONICE, San Miguel De Tucuman, Argentina.
EM misla@tucbbs.com.ar
RI Alberto, Maria Rosa/AAS-3062-2021
OI Isla, Maria Ines/0000-0002-4261-4284; Alberto, Maria
   Rosa/0000-0002-4173-9499
FU ANPCyT [PICT 3136]; SCAIT-UNT [PIUNT G-533]; CONICET (PIP)
FX We thank ANPCyT (PICT 3136) "Revalorizacion de frutos nativos del NOA y
   sus productos derivados como alimentos funcionales no convencionales,"
   CONICET (PIP) and SCAIT-UNT (PIUNT G-533) for financial support.
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NR 37
TC 21
Z9 21
U1 0
U2 13
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-1147
EI 1750-3841
J9 J FOOD SCI
JI J. Food Sci.
PD MAY
PY 2018
VL 83
IS 5
BP 1454
EP 1462
DI 10.1111/1750-3841.14113
PG 9
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA GF5MR
UT WOS:000432012200035
PM 29660809
OA Green Published
DA 2025-06-11
ER

PT J
AU Nogales, F
   Ojeda, ML
   del Valle, PM
   Serrano, A
   Murillo, ML
   Sánchez, OC
AF Nogales, Fatima
   Luisa Ojeda, M.
   Munoz del Valle, Paulina
   Serrano, Alejandra
   Luisa Murillo, M.
   Carreras Sanchez, Olimpia
TI Metabolic syndrome and selenium during gestation and lactation
SO EUROPEAN JOURNAL OF NUTRITION
LA English
DT Article
DE Metabolic syndrome; Selenium; Gestation; Lactation
ID OXIDATIVE STRESS; GLUTATHIONE-PEROXIDASE; CARDIOVASCULAR-DISEASE;
   INSULIN-RESISTANCE; FRUCTOSE; SUPPLEMENTATION; MICE; DEFICIENCY;
   CARBOHYDRATE; PREGNANCY
AB Selenium (Se) has a dual role in metabolic syndrome (MS) development as it has an antioxidant action against both "good" and "bad" reactive oxygen species. This study evaluates Se body profile in dams which present MS during gestation and lactation, in order to elucidate a normal dietary Se's implication in this pathology.
   Rats were randomized into control (C) and fructose (F) groups. The rich fructose diet (65 %) during gestation and lactation periods induced MS in dams. Se body distribution was determined by atomic absorption spectrophotometry, and the hepatic activity of the four antioxidant enzymes and the bimolecular oxidation were determined by spectrophotometry. The cardiac activity was monitored using the indirect tail occlusion method. Lipid and glucidic profile was also analyzed.
   Despite the fact that the diet supplied has 0.1 ppm of Se, the minimal dietary requirement for rats, F dams ate less amount of food, and therefore, they had lower Se retention. However, they had normal levels of Se in serum and milk. Dams with MS had Se depletion in heart and muscle joint to hypertension and a lower heart rate, and Se repletion in liver and kidney. Despite the increase in hepatic glutathione peroxidase (GPx) and catalase activity found, lipid oxidation occurred-probably because superoxide dismutase activity was diminished. In heart, the activity and expression of the selenoprotein GPx1 were decreased.
   With these results, it is not possible to elucidate whether a dietary Se supplementation or a Se-restricted diet are good for MS; because despite the fact that GPx activity is increased in liver, it is also found, for the first time, that heart Se deposits are significantly decreased during MS.
C1 [Nogales, Fatima; Luisa Ojeda, M.; Munoz del Valle, Paulina; Serrano, Alejandra; Luisa Murillo, M.; Carreras Sanchez, Olimpia] Univ Seville, Dept Physiol, Fac Pharm, C Prof Garcia Gonzalez 2, E-41012 Seville, Spain.
C3 University of Sevilla
RP Sánchez, OC (corresponding author), Univ Seville, Dept Physiol, Fac Pharm, C Prof Garcia Gonzalez 2, E-41012 Seville, Spain.
EM olimpia@us.es
RI Nogales, F/B-8562-2019; Carreras, olimpia/P-9078-2019; Ojeda,
   Luisa/B-8571-2019
OI Maria Luisa, Ojeda Murillo/0000-0002-9160-2749; Carreras,
   Olimpia/0000-0002-3858-0165; Nogales, Fatima/0000-0003-4844-2740
FU Andalusian Regional Government
FX The authors acknowledge the grants from Andalusian Regional Government
   for its support to CTS-193 research group.
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NR 55
TC 15
Z9 15
U1 0
U2 8
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1436-6207
EI 1436-6215
J9 EUR J NUTR
JI Eur. J. Nutr.
PD MAR
PY 2017
VL 56
IS 2
BP 819
EP 830
DI 10.1007/s00394-015-1129-1
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA EN5IR
UT WOS:000396039300034
PM 26680597
DA 2025-06-11
ER

PT J
AU Tabur, S
   Oztuzcu, S
   Oguz, E
   Korkmaz, H
   Eroglu, S
   Ozkaya, M
   Demiryürek, AT
AF Tabur, S.
   Oztuzcu, S.
   Oguz, E.
   Korkmaz, H.
   Eroglu, S.
   Ozkaya, M.
   Demiryurek, A. T.
TI Association of Rho/Rho-kinase gene polymorphisms and expressions with
   obesity-related metabolic syndrome
SO EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
LA English
DT Article
DE Diabetes mellitus; Metabolic syndrome; Obesity; Rhokinase; Rho proteins
ID SMOOTH-MUSCLE-CELLS; RHO-KINASE; INSULIN-RESISTANCE; ENDOTHELIAL-CELLS;
   OXIDATIVE STRESS; PROTEINS; CHOLESTEROL; POPULATION; VARIANTS; PATHWAY
AB OBJECTIVE: The metabolic syndrome (MetS) is a common multicomponent condition including abdominal obesity, dyslipidemia, hypertension and hyperglycemia. The aim of this study was to investigate the associations of Rho GTPase and Rho-kinase (ROCK) gene polymorphisms and expressions with MetS in a Turkish population.
   PATIENTS AND METHODS: A total of 141 obese MetS patients and 163 healthy controls with similar age and sex were included to this study. Polymorphisms were analyzed in genomic DNA using a BioMark 96.96 dynamic array system. mRNA from blood samples was extracted, and real-time polymerase chain reaction was performed for gene expressions.
   RESULTS: We observed that genotype (CC, 18.1%; CA, 13.4%, and AA, 68.5%) and allele (C, 24.8%; A, 75.2%) frequencies for the rs35996865 polymorphism of the ROCK1 gene in patients were markedly different from controls (CC, 84.2%; CA, 2.9%, and AA, 12.9%; C, 85.6%; A, 14.4%, p < 0.0001). In the rs2230774 (Thr431Asn) polymorphism of the ROCK2 gene, there were increases in the CC genotype (16.5%) and C allele frequencies (20.4%) in MetS patients when compared with the control group (CC, 6.0%, p = 0.0009, and C, 6.7%, p < 0.0001). However, no associations with the other 18 polymorphisms studied were found. Although there were an increase in peripheral blood mRNA RhoH expressions, marked decreases in RhoC, RhoBTB1, RhoV, Rnd1, and CDC42 gene expressions were noted in MetS patients.
   CONCLUSIONS: This is the first study to provide evidence that ROCK gene polymorphisms and gene expressions of the Rho GTPase proteins may modify individual susceptibility to MetS in the Turkish population.
C1 [Tabur, S.; Korkmaz, H.; Ozkaya, M.] Gaziantep Univ, Fac Med, Dept Internal Med, Div Endocrinol, Gaziantep, Turkey.
   [Oztuzcu, S.; Eroglu, S.] Gaziantep Univ, Fac Med, Dept Med Biol, Gaziantep, Turkey.
   [Oguz, E.] Harran Univ, Fac Med, Dept Med Pharmacol, Sanliurfa, Turkey.
   [Demiryurek, A. T.] Gaziantep Univ, Fac Med, Dept Med Pharmacol, Gaziantep, Turkey.
C3 Gaziantep University; Gaziantep University; Harran University; Gaziantep
   University
RP Tabur, S (corresponding author), Gaziantep Univ, Fac Med, Dept Internal Med, Div Endocrinol, Gaziantep, Turkey.
EM suzan2471@yahoo.com.tr
RI Eroglu, Secil/P-2209-2019; Demiryurek, Abdullah/AAG-5244-2020; Oguz,
   Elif/KCZ-1767-2024
OI Eroglu, Secil/0000-0002-1536-1736
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NR 39
TC 17
Z9 19
U1 0
U2 4
PU VERDUCI PUBLISHER
PI ROME
PA VIA GREGORIO VII, ROME, 186-00165, ITALY
SN 1128-3602
J9 EUR REV MED PHARMACO
JI Eur. Rev. Med. Pharmacol. Sci.
PD MAY
PY 2015
VL 19
IS 9
BP 1680
EP 1688
PG 9
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA CJ8IV
UT WOS:000355744400021
PM 26004609
DA 2025-06-11
ER

PT J
AU Liu, J
   Shi, WQ
   Cao, Y
   He, LP
   Guan, K
   Ling, WH
   Chen, YM
AF Liu, Jun
   Shi, Wen-qi
   Cao, Yi
   He, Li-ping
   Guan, Ke
   Ling, Wen-hua
   Chen, Yu-ming
TI Higher serum carotenoid concentrations associated with a lower
   prevalence of the metabolic syndrome in middle-aged and elderly Chinese
   adults
SO BRITISH JOURNAL OF NUTRITION
LA English
DT Article
DE Carotenoids; Serum; Metabolic syndrome; Cross-sectional studies
ID ANTIOXIDANT CONCENTRATIONS; ENDOTHELIAL DYSFUNCTION; OXIDATIVE STRESS;
   RISK; MARKERS; HEALTH
AB The association between serum carotenoids and the metabolic syndrome (MetS) remains uncertain, and little is known about this relationship in the Chinese population. The present study examined the association between serum carotenoid concentrations and the MetS in Chinese adults. We conducted a community-based cross-sectional study in which 2148 subjects (1547 women and 601 men) aged 50-75 years were recruited in urban Guangzhou, China. Dietary data and other covariates were collected during face-to-face interviews. Blood pressure, waist circumference, blood lipids, glucose and serum carotenoids (alpha-, beta-carotene, beta-cryptoxanthin, lycopene and lutein/zeaxanthin) were examined. We found dose-response inverse relationships between individual serum carotenoid concentrations and total carotenoids and the prevalence of the MetS after adjusting for potential confounders (P for trend <0.001). The OR of the MetS for the highest (v. lowest) quartile were 0.31 (95% CI 0.20, 0.47) for alpha-carotene, 0.23 (95% CI 0.15, 0.36) for beta-carotene, 0.44 (95% CI 0.29, 0.67) for beta-cryptoxanthin, 0.39 (95% CI 0.26, 0.58) for lycopene, 0.28 (95% CI 0.18, 0.44) for lutein + zeaxanthin and 0.19 (95% CI 0.12, 0.30) for total carotenoids. Higher concentrations of each individual carotenoid and total carotenoids were significantly associated with a decrease in the number of abnormal MetS components (P for trend <0.001-0.023). Higher serum carotenoid levels were associated with a lower prevalence of the MetS and fewer abnormal MetS components in middle-aged and elderly Chinese adults.
C1 [Liu, Jun; Shi, Wen-qi; Cao, Yi; He, Li-ping; Guan, Ke; Ling, Wen-hua; Chen, Yu-ming] Sun Yat Sen Univ, Dept Med Stat & Epidemiol, Sch Publ Hlth, Guangdong Prov Key Lab Food Nutr & Hlth, Guangzhou 510080, Guangdong, Peoples R China.
   [Liu, Jun] Zunyi Med Univ, Sch Publ Hlth, Zunyi 563003, Guizhou, Peoples R China.
   [He, Li-ping] Guangzhou Panyu Cent Hosp, Guangzhou 511430, Guangdong, Peoples R China.
C3 Sun Yat Sen University; Zunyi Medical University
RP Chen, YM (corresponding author), Sun Yat Sen Univ, Dept Med Stat & Epidemiol, Sch Publ Hlth, Guangdong Prov Key Lab Food Nutr & Hlth, Guangzhou 510080, Guangdong, Peoples R China.
EM chenyum@mail.sysu.edu.cn
OI chen, Yu-ming/0000-0003-1658-5528
FU National Natural Science Foundation of China [81130052]; Sun Yat-sen
   University, Guangzhou, People's Republic of China [2007032]
FX The present study was jointly supported by the Key Program of National
   Natural Science Foundation of China (no. 81130052) and the 5010 Program
   for Clinical Researches (no. 2007032) by the Sun Yat-sen University,
   Guangzhou, People's Republic of China. The sponsor had no role in the
   design and analysis of the study or in the writing of this article.
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NR 35
TC 49
Z9 52
U1 0
U2 17
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1145
EI 1475-2662
J9 BRIT J NUTR
JI Br. J. Nutr.
PD DEC 28
PY 2014
VL 112
IS 12
BP 2041
EP 2048
DI 10.1017/S000711451400316X
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA AX7OA
UT WOS:000347103800016
PM 25345663
OA Bronze
DA 2025-06-11
ER

PT J
AU Shab-Bidar, S
   Hosseini-Esfahani, F
   Mirmiran, P
   Mehran, M
   Azizi, F
AF Shab-Bidar, Sakineh
   Hosseini-Esfahani, Firoozeh
   Mirmiran, Parvin
   Mehran, Mahya
   Azizi, Fereidoun
TI Dietary intakes of zinc and copper and cardiovascular risk factors in
   Tehranian adults: Tehran Lipid and Glucose Study
SO NUTRITION & DIETETICS
LA English
DT Article
DE cardiovascular disease risk factor; copper; dietary intake; metabolic
   syndrome; zinc
ID CORONARY-ARTERY-DISEASE; OXIDATIVE STRESS; SERUM COPPER; METABOLIC
   SYNDROME; HEART-DISEASE; SUPPLEMENTATION; PREVENTION; MAGNESIUM; PLASMA;
   CANCER
AB AimThe aim of the present study was to investigate the intakes of zinc and copper in relation to cardiovascular disease (CVD) risk factors in a group of Tehranian adults.
   MethodsThe present cross-sectional study was conducted on 2750 individuals, selected among participants of the Tehran Lipid and Glucose Study. Dietary intake was assessed using a validated semi-quantitative food frequency questionnaire. Metabolic syndrome (MetS) and CVD risk factors were evaluated.
   ResultsAfter adjustment of possible confounders, the dietary zinc intake was found to have a negative relation with serum HDL-C ( = -0.47, P = 0.027), triglycerides (TG) ( = -0.003, P = 0.032) and 2-hour blood glucose ( = -1.6, P = 0.017) levels in women. Prevalence of MetS was not associated with dietary zinc intake when confounding factors were included in the statistical model. Comparing the highest versus the lowest intake categories of dietary copper, the multivariable adjusted odds ratios for HDL-C, fasting blood glucose(FBG), TG and MetS were 1.75 (1.43-2.25)(P for trend = 0.003), 0.90 (0.76-1.23)(P for trend = 0.017), 0.11(0.08-0.21) (P for trend = 0.042) and 0.19 (0.15-0.38)(P for trend = 0.023), respectively.
   ConclusionsThe results indicate gender differences in the association between zinc intake and CVD risk factors; in women, lower consumption of dietary zinc was associated with increased levels of serum TG and 2-hour BG and decreased levels of HDL-C, while Copper intake was negatively associated with higher risk of MetS and its components (FBG, HDL-C and TG).
C1 [Shab-Bidar, Sakineh; Hosseini-Esfahani, Firoozeh; Mehran, Mahya] Shahid Beheshti Univ Med Sci, Nutr & Endocrine Res Ctr, Obes Res Ctr, Res Inst Endocrine Sci, Tehran, Iran.
   [Mirmiran, Parvin] Shahid Beheshti Univ Med Sci, Dept Human Nutr & Dietet, Fac Nutr Sci & Food Technol, Natl Nutr & Food Technol Res Inst, Tehran, Iran.
   [Azizi, Fereidoun] Shahid Beheshti Univ Med Sci, Res Inst Endocrine Sci, Endocrine Res Ctr, Tehran, Iran.
C3 Shahid Beheshti University Medical Sciences; Shahid Beheshti University
   Medical Sciences; Shahid Beheshti University Medical Sciences
RP Mirmiran, P (corresponding author), Shahid Beheshti Univ Med Sci, Res Inst Endocrine Sci, Obes Res Ctr, POB 19395-4763, Tehran, Iran.
EM parvin.mirmiran@gmail.com
RI Mirmiran, Parvin/V-1433-2019; Shab-Bidar, Sakineh/H-9525-2017;
   Hosseini-Esfahani, Firoozeh/K-9532-2017; Azizi, Fereidoun/ABD-4136-2021
OI Shab-Bidar, Sakineh/0000-0002-0167-7174; Hosseini-Esfahani,
   Firoozeh/0000-0002-9697-0081; Mirmiran, Parvin/0000-0003-2391-4924;
   Azizi, Fereidoun/0000-0002-6470-2517
FU National Research Council of the Islamic Republic of Iran [121];
   Research Institute for Endocrinology and Metabolism, Shahid Beheshti
   University of Medical Sciences [121]
FX The present study was supported by grant no. 121 from the combined
   support of the National Research Council of the Islamic Republic of Iran
   and Research Institute for Endocrinology and Metabolism, Shahid Beheshti
   University of Medical Sciences. No financial conflict of interest was
   reported by the authors of the present paper.
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NR 49
TC 7
Z9 7
U1 0
U2 9
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1446-6368
EI 1747-0080
J9 NUTR DIET
JI Nutr. Diet.
PD SEP
PY 2013
VL 70
IS 3
BP 218
EP 226
DI 10.1111/1747-0080.12026
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 227CN
UT WOS:000325085900009
OA Bronze
DA 2025-06-11
ER

PT J
AU Li, YR
   Guo, HW
   Liu, M
AF Li, Yanrong
   Guo, Hongwei
   Liu, Ming
TI Serum and dietary antioxidant status is associated with lower prevalence
   of the metabolic syndrome in a study in Shanghai, China
SO ASIA PACIFIC JOURNAL OF CLINICAL NUTRITION
LA English
DT Article
DE human; antioxidant; serum; diet; metabolic syndrome
ID NUTRITION EXAMINATION SURVEY; OXIDATIVE STRESS MARKERS; 3RD
   NATIONAL-HEALTH; C-REACTIVE PROTEIN; INSULIN-RESISTANCE; RISK-FACTORS;
   INFLAMMATION; ADULTS; ZINC; FAT
AB Objective: The aim of our study was to examine the association between the metabolic syndrome (MS) and serum antioxidant status. Methods: A cross-sectional study was conducted with 221 cases and 329 controls aged 18 to 65 years. Weight, height, body mass index, waist circumference, blood pressure, fasting blood glucose and lipids, as well as serum superoxide dismutase, glutathione peroxidase, malondialdehide, vitamins A, E, beta-carotene and lycopene were examined. Intakes of antioxidants were also estimated. Results: Mean serum superoxide dismutase activity, beta-carotene concentrations were significantly lower, malondialdehide was higher (p<0.05) in persons with the MS (after adjusting for age, sex) than those without. Superoxide dismutase, glutathione peroxidase, and beta-carotene also decreased significantly (p<0.05) with increased number of components of the MS. Low levels of serum superoxide dismutase activity and beta-carotene concentration appeared to be associated with the MS status. Moreover, dietary energy, carbohydrate, vitamin C, zinc and copper intake in the MS patients were lower, but fat intake were higher. Vitamins E, C and manganese intake decreased with the elevated number of the MS components. For zinc and manganese, a lower risk was observed for other quartile of intake compared with the first one. Inverse links between dietary fat, energy intake and serum antioxidant status were found in MS patients, meanwhile dietary vitamin C was positively related with serum antioxidant level. Conclusions: Serum antioxidant status was associated with a lower prevalence of the MS, and with lower dietary fat, energy intake and higher vitamin C intake.
C1 [Li, Yanrong; Guo, Hongwei; Liu, Ming] Fudan Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Shanghai 200032, Peoples R China.
C3 Fudan University
RP Guo, HW (corresponding author), Fudan Univ, Sch Publ Hlth, Dept Nutr, 130 Dongan Rd, Shanghai 200032, Peoples R China.
EM hwguo@shmu.edu.cn
RI 刘, 明/HJG-8648-2022
FU Danone Dietary Nutrition for Research and Teaching
FX The study was funded by Danone Dietary Nutrition for Research and
   Teaching. There was no relationship that may pose a conflict of
   interest.
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NR 33
TC 66
Z9 70
U1 0
U2 15
PU H E C PRESS, HEALTHY EATING CLUB PTY LTD
PI MCKINNON
PA PO BOX 4121, MCKINNON, VIC 3204, AUSTRALIA
SN 0964-7058
EI 1440-6047
J9 ASIA PAC J CLIN NUTR
JI Asia Pac. J. Clin. Nutr.
PY 2013
VL 22
IS 1
BP 60
EP 68
DI 10.6133/apjcn.2013.22.1.06
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 158ZU
UT WOS:000320014600009
PM 23353612
DA 2025-06-11
ER

PT J
AU Sikora, J
   Broncel, M
   Markowicz, M
   Chalubinski, M
   Wojdan, K
   Mikiciuk-Olasik, E
AF Sikora, Joanna
   Broncel, Marlena
   Markowicz, Magdalena
   Chalubinski, Maciej
   Wojdan, Katarzyna
   Mikiciuk-Olasik, Elzbieta
TI Short-term supplementation with Aronia melanocarpa extract
   improves platelet aggregation, clotting, and fibrinolysis in patients
   with metabolic syndrome
SO EUROPEAN JOURNAL OF NUTRITION
LA English
DT Article
DE Aronia; Coagulation; Fibrinolysis; Metabolic syndrome; Platelet
   aggregation
ID BLOOD-PRESSURE; OXIDATIVE STRESS; CONSUMPTION; PARAMETERS; PLASMA; JUICE
AB A diet rich in berries is believed to play a distinct role in the prevention of metabolic diseases associated with obesity. So far, there have been no published clinical observations evaluating the influence of Aronia melanocarpa on hemostasis. The aim of our study was to investigate the effects of A. melanocarpa extract (AM) supplementation on platelet aggregation, clot formation, and lysis in patients with metabolic syndrome (MS).
   Middle-aged non-medicated subjects with MS (n = 38) and 14 healthy volunteers were included in this study. Patients with MS were treated with 100 mg of AM three times daily for 2 months.
   We observed a significant reduction in the concentration of TC, LDL-C, and TG after AM supplementation. Beneficial changes in coagulation parameters were also observed. After 1 month of AM administration, we noticed significant inhibition of platelet aggregation. However, this effect became less pronounced after 2 months of supplementation. In the case of coagulation induced by endogenic thrombin, a significant decrease in the overall potential for coagulation was induced after 1 or 2 months of supplementation. Moreover, after 1 month of AM extract supplementation, we observed a beneficial reduction in the overall potential for clot formation and fibrinolysis.
   We observed the normalization of hemostasis parameters in MS patients after both 1 and 2 months of AM administration. After 1 month of AM supplementation, we found favorable changes in regards to the overall potential for plasma clotting, clot formation, and lysis, as well as in the lipid profiles of subjects.
C1 [Sikora, Joanna; Markowicz, Magdalena; Mikiciuk-Olasik, Elzbieta] Med Univ Lodz, Dept Pharmaceut Chem & Drug Anal, PL-90151 Lodz, Poland.
   [Broncel, Marlena; Chalubinski, Maciej; Wojdan, Katarzyna] Med Univ Lodz, Dept Internal Dis & Clin Pharmacol, PL-91347 Lodz, Poland.
C3 Medical University Lodz; Medical University Lodz
RP Sikora, J (corresponding author), Med Univ Lodz, Dept Pharmaceut Chem & Drug Anal, Muszynskiego 1, PL-90151 Lodz, Poland.
EM joanna.sikora@umed.lodz.pl
RI Sikora, Joanna/J-5197-2012; Mikiciuk-Olasik, Elzbieta/D-5091-2011;
   Markowicz-Piasecka, Magdalena/S-6673-2016
OI Mikiciuk-Olasik, Elzbieta/0000-0002-7171-4524; Broncel,
   Marlena/0000-0003-3659-8115; Sikora, Joanna/0000-0001-7044-9696;
   Markowicz-Piasecka, Magdalena/0000-0002-1012-6550; Chalubinski,
   Maciej/0000-0001-8311-9530
FU Polish Ministry of Science and Higher Education [N N405 062934]
FX This study was supported by project N N405 062934 of the Polish Ministry
   of Science and Higher Education.
CR Antovic A, 2010, SEMIN THROMB HEMOST, V36, P772, DOI 10.1055/s-0030-1265294
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NR 25
TC 61
Z9 62
U1 0
U2 27
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1436-6207
EI 1436-6215
J9 EUR J NUTR
JI Eur. J. Nutr.
PD AUG
PY 2012
VL 51
IS 5
BP 549
EP 556
DI 10.1007/s00394-011-0238-8
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 975XI
UT WOS:000306544600004
PM 21850495
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Chakravarthy, MV
   Zhu, Y
   Yin, L
   Coleman, T
   Pappan, KL
   Marshall, CA
   McDaniel, ML
   Semenkovich, CF
AF Chakravarthy, Manu V.
   Zhu, Yimin
   Yin, Li
   Coleman, Trey
   Pappan, Kirk L.
   Marshall, Connie A.
   McDaniel, Michael L.
   Semenkovich, Clay F.
TI Inactivation of hypothalamic FAS protects mice from diet-induced obesity
   and inflammation
SO JOURNAL OF LIPID RESEARCH
LA English
DT Article
DE metabolic syndrome; insulin resistance; type 2 diabetes mellitus
ID INDUCED INSULIN-RESISTANCE; ACTIVATES PPAR-ALPHA; FATTY-ACID OXIDATION;
   ADIPOSE-TISSUE; METABOLIC SYNDROME; SKELETAL-MUSCLE; GLUCOSE-METABOLISM;
   MALONYL-COA; FOOD-INTAKE; BETA
AB Obesity promotes insulin resistance and chronic inflammation. Disrupting any of several distinct steps in lipid synthesis decreases adiposity, but it is unclear if this approach coordinately corrects the environment that propagates metabolic disease. We tested the hypothesis that inactivation of FAS in the hypothalamus prevents diet-induced obesity and systemic inflammation. Ten weeks of high-fat feeding to mice with inactivation of FAS (FASKO) limited to the hypothalamus and pancreatic beta cells protected them from diet-induced obesity. Though high-fat fed FASKO mice had no beta-cell phenotype, they were hypophagic and hypermetabolic, and they had increased insulin sensitivity at the liver but not the periphery as demonstrated by hyperinsulinemic-euglycemic clamps, and biochemically by increased phosphorylated Akt, glycogen synthase kinase-3beta, and FOXO1 compared with wild-type mice. High-fat fed FASKO mice had decreased excretion of urinary isoprostanes, suggesting less oxidative stress and blunted tumor necrosis factor alpha (TNF alpha) and interleukin-6 (IL-6) responses to endotoxin, suggesting less systemic inflammation. Pair-feeding studies demonstrated that these beneficial effects were dependent on central FAS disruption and not merely a consequence of decreased adiposity. Thus, inducing central FAS deficiency may be a valuable integrative strategy for treating several components of the metabolic syndrome, in part by correcting hepatic insulin resistance and suppressing inflammation.-Chakravarthy, M. V., Y. Zhu, L. Yin, T. Coleman, K. L. Pappan, C. A. Marshall, M. L. McDaniel, and C. F. Semenkovich. Inactivation of hypothalamic FAS protects mice from diet-induced obesity and inflammation. J. Lipid Res. 2009. 50: 630-640.
C1 [Chakravarthy, Manu V.; Zhu, Yimin; Yin, Li; Coleman, Trey; Semenkovich, Clay F.] Washington Univ, Sch Med, Dept Med, St Louis, MO 63110 USA.
   [Pappan, Kirk L.; Marshall, Connie A.; McDaniel, Michael L.] Washington Univ, Sch Med, Dept Pathol & Immunol, Div Endocrinol Metab & Lipid, St Louis, MO 63110 USA.
   [Semenkovich, Clay F.] Washington Univ, Sch Med, Dept Cell Biol & Physiol, St Louis, MO 63110 USA.
C3 Washington University (WUSTL); Washington University (WUSTL); Washington
   University (WUSTL)
RP Semenkovich, CF (corresponding author), Washington Univ, Sch Med, Dept Med, St Louis, MO 63110 USA.
EM csemenko@wustl.edu
RI Pappan, Kirk/AAV-5946-2021; Chakravarthy, Manu/AAD-7553-2021;
   Segura-Aguilar, Juan/H-8839-2013
OI Semenkovich, Clay/0000-0003-1163-1871; Pappan, Kirk/0000-0002-2341-8798
FU American Diabetes Association [1-07-JF-12]; Mentor-Based Postdoctoral
   Fellowship Award; National Institutes of Health [DK076729, P50
   HL083762]; Clinical Nutrition Research Unit [DK56341]; Diabetes Research
   and Training Center [DK20579]
FX This work was supported by the American Diabetes Association ( Junior
   Faculty Award 1-07-JF-12 to MVC and a Mentor-Based Postdoctoral
   Fellowship Award), National Institutes of Health grants DK076729 and P50
   HL083762, and the Clinical Nutrition Research Unit (DK56341) and
   Diabetes Research and Training Center (DK20579).
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NR 50
TC 36
Z9 45
U1 0
U2 3
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0022-2275
EI 1539-7262
J9 J LIPID RES
JI J. Lipid Res.
PD APR
PY 2009
VL 50
IS 4
BP 630
EP 640
DI 10.1194/jlr.M800379-JLR200
PG 11
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 420IV
UT WOS:000264283800005
PM 19029118
OA Green Submitted, Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Shan, SH
   Yin, RP
   Shi, JY
   Zhang, LZ
   Zhou, JQ
   Qiao, QQ
   Dong, XS
   Zhao, WJ
   Li, ZY
AF Shan, Shuhua
   Yin, Ruopeng
   Shi, Jiangying
   Zhang, Lizhen
   Zhou, Jiaqi
   Qiao, Qinqin
   Dong, Xiushan
   Zhao, Wenjing
   Li, Zhuoyu
TI Gut microbiota remodeling drived by dietary millet protein prevents the
   metabolic syndrome
SO FOOD SCIENCE AND HUMAN WELLNESS
LA English
DT Article
DE Metabolic syndrome; Gut microbiota; Extract of millet bran protein;
   Gamma-aminobutyric acid; Gut barrier function
ID OXYGEN-GLUCOSE DEPRIVATION; HIGH-FAT DIET; OXIDATIVE STRESS; OBESITY;
   INFLAMMATION; DYSFUNCTION; WEIGHT; HEALTH
AB Metabolic syndrome (MetS) is a chronic disease associated with the disturbance of gut microbiota homeostasis. Metabolites derived from gut microbes play essential roles in MetS prevention and therapy. Here, we focused on the inhibitory effect of the extract of millet bran protein (EMBP) on a high -fat diet (HFD)induced MetS, aiming to identify gut microbiota and their metabolites that involve in the anti-MetS activity of EMBP. The obesity, chronic inflammation, insulin resistance in MetS mouse models were abolished after EMBP treatment. The protective mechanism of EMBP against HFD-induced MetS may depend on improved gut barrier function. Using microbiome analysis, we found that EMBP supplementation improved gut microbiome dysbiosis in MetS mice, specifically upregulating Bacteroides acidifaciens . The fecal microbiota transplantation (FMT) also demonstrated this phenomenon. In addition, metabolomic analysis showed that EMBP mediates metabolic profiling reprogramming in MetS mice. Notably, a microbiota-derived metabolite, gamma-aminobutyric acid (GABA), is enriched by EMBP. In addition, exogenous GABA treatment produced a similar protective effect to EMBP by improving NRF2-dependent gut barrier function to protect HFDinduced MetS. The results suggest that EMBP suppress host MetS by remodeling of gut microbiota as an effective candidate for next -generation medicine food dual purpose dietary supplement to intervene in MetS. (c) 2024 Beijing Academy of Food Sciences. Publishing services by Tsinghua University Press. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
C1 [Shan, Shuhua; Zhou, Jiaqi; Qiao, Qinqin; Li, Zhuoyu] Shanxi Univ, Inst Biotechnol, Key Lab Chem Biol & Mol Engn, Natl Minist Educ, Taiyuan 030006, Peoples R China.
   [Zhang, Lizhen] Shanxi Univ, Sch Life Sci, Taiyuan 030006, Peoples R China.
   [Dong, Xiushan] Shanxi Med Univ, Shanxi Bethune Hosp, Tongji Shanxi Hosp, Hosp 3,Shanxi Acad Med Sci, Taiyuan 030032, Peoples R China.
   [Zhao, Wenjing] Taiyuan Normal Univ, Biol Sci & Technol Coll, Dept Biol, Jinzhong 030619, Peoples R China.
C3 Shanxi University; Shanxi University; Shanxi Medical University; Taiyuan
   Normal University
RP Shan, SH; Li, ZY (corresponding author), Shanxi Univ, Inst Biotechnol, Key Lab Chem Biol & Mol Engn, Natl Minist Educ, Taiyuan 030006, Peoples R China.
EM ssh@sxu.edu.cn; lzy@sxu.edu.cn
RI Shan, Shuhua/MZR-6507-2025; Zhuoyu, Li/GXZ-8401-2022
FU National Natural Science Foundation of China [32270420, 32072220];
   National Key Research and Development Project [2020YFD1001405]; Shanxi
   Province Science Foundation [202103021224011]; Shanxi Key Laboratory for
   Research and Development of Regional Plants; Shanxi Province "136"
   Revitalization Medical Project Construction Funds
FX The authors gratefully acknowledge China Institute of Radiation
   Protection for providing animal care facility; the technical support by
   the Servicebio Co., Ltd. is also appreciated; the sequencing and
   bioinformatics analysis are provided by Personal Co., Ltd., Biotree Co.,
   Ltd. and Novogene Co., Ltd.; the elements provided by Figdraw for
   Graphical abstract are referenced.This study was supported by National
   Natural Science Foundation of China (32270420, 32072220), National Key
   Research and Development Project (2020YFD1001405), Shanxi Province
   Science Foundation (202103021224011), Shanxi Key Laboratory for Research
   and Development of Regional Plants, Shanxi Province "136" Revitalization
   Medical Project Construction Funds.
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NR 58
TC 2
Z9 2
U1 9
U2 28
PU TSINGHUA UNIV PRESS
PI BEIJING
PA B605D, XUE YAN BUILDING, BEIJING, 100084, PEOPLES R CHINA
EI 2213-4530
J9 FOOD SCI HUM WELL
JI Food Sci. Human Wellness
PD JUL
PY 2024
VL 13
IS 4
BP 1987
EP 2001
DI 10.26599/FSHW.2022.9250165
PG 15
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA UC0Z1
UT WOS:001245757900001
OA gold
DA 2025-06-11
ER

PT J
AU Baghery, F
   Mohammadifard, N
   Falahati-Pour, SK
AF Baghery, Fatemeh
   Mohammadifard, Noushin
   Falahati-Pour, Soudeh Khanamani
TI The effect of pistachio supplementation on metabolic syndrome and its
   components in adults: a systematic review and meta-analysis of
   randomized controlled trials
SO NUTRITION REVIEWS
LA English
DT Review
DE metabolic syndrome; meta-analysis; pistachio; systematic review
ID NUT CONSUMPTION; ENDOTHELIAL FUNCTION; BLOOD-PRESSURE; INFLAMMATION;
   PARAMETERS; PROFILE; STRESS
AB Context Several observational and experimental studies have been conducted to evaluate the effects of pistachio intake on metabolic syndrome (MetS); however, the results are inconsistent. Objective This systematic review and meta-analysis were performed on data from randomized controlled trials (RCTs) to determine the effect of pistachio consumption on MetS components. Data sources The PubMed, Scopus, Google Scholar and Web of Science databases were searched from 1986 to 2021. Study selection English-language RCTs on pistachio intake were included that provided outcomes on hypertension, hyperglycemia, hypertriglyceridemia, and high-density lipoprotein (HDL). Data extraction Results are presented as pooled mean differences (MDs) between intervention and control groups with 95%CI reported for each of the components. Results Seventeen RCTs including 940 adults met the inclusion criteria for this systematic review and meta-analysis. Pistachio supplementation significantly reduced systolic blood pressure (BP; MD, -2.89 mmHg, 95%CI: -4.11 to -1.67; P < 0.001), triglycerides (MD, -16.76 mg/dL, 95%CI: -16.89 to -16.64; P < 0.001), fasting blood glucose (MD, -3.62 mg/dL, 95%CI: -6.45 to -0.8; P < 0.001,) and increased HDL (MD, 1.43 mg/dL, 95%CI: 1.39 to 1.47; P < 0.001) levels. However, there were not observed considerable changes in waist circumference, diastolic BP, and body mass index. Conclusion The results of this research show that pistachio consumption could improve some MetS components, including systolic blood pressure, triglyceride, fasting blood glucose, and HDL levels, without affecting anthropometric indices and diastolic BP.
C1 [Baghery, Fatemeh; Falahati-Pour, Soudeh Khanamani] Rafsanjan Univ Med Sci, Pistachio Safety Res Ctr, POB 77177735979, Rafsanjan, Iran.
   [Mohammadifard, Noushin] Isfahan Univ Med Sci, Cardiovasc Res Inst, Isfahan Cardiovasc Res Ctr, Esfahan, Iran.
C3 Isfahan University of Medical Sciences
RP Falahati-Pour, SK (corresponding author), Rafsanjan Univ Med Sci, Pistachio Safety Res Ctr, POB 77177735979, Rafsanjan, Iran.
EM S.falahatipour@rums.ac.ir
RI Merat, Shahin/A-5478-2009; Falahati, Soudeh/M-3678-2017
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TC 7
Z9 7
U1 4
U2 11
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0029-6643
EI 1753-4887
J9 NUTR REV
JI Nutr. Rev.
PD SEP 5
PY 2022
VL 80
IS 10
BP 2051
EP 2063
DI 10.1093/nutrit/nuac027
EA JUN 2022
PG 13
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 4K0BG
UT WOS:000809430600001
PM 35689651
OA Bronze
DA 2025-06-11
ER

PT J
AU Cheng, CH
   Lin, CY
   Cho, TH
   Lin, CM
AF Cheng, Chao-Hsin
   Lin, Ching-Yuan
   Cho, Tsung-Hsun
   Lin, Chih-Ming
TI Machine Learning to Predict the Progression of Bone Mass Loss Associated
   with Personal Characteristics and a Metabolic Syndrome Scoring Index
SO HEALTHCARE
LA English
DT Article
DE osteopenia; metabolic syndrome; socioeconomic status; lifestyle; machine
   learning
ID ARTIFICIAL NEURAL-NETWORKS; MINERAL DENSITY; RISK-FACTORS; HEALTH; HIP;
   CALCIFICATION; FRACTURE; STRESS; ADULTS; KOREA
AB A relationship exists between metabolic syndrome (MetS) and human bone health; however, whether the combination of demographic, lifestyle, and socioeconomic factors that are associated with MetS development also simultaneously affects bone density remains unclear. Using a machine learning approach, the current study aimed to estimate the usefulness of predicting bone mass loss using these potentially related factors. The present study included a sample of 23,497 adults who routinely visited a health screening center at a large health center at least once during each of three 3-year stages (i.e., 2006-2008, 2009-2011, and 2012-2014). The demographic, socioeconomic, lifestyle characteristics, body mass index (BMI), and MetS scoring index recorded during the first 3-year stage were used to predict the subsequent occurrence of osteopenia using a non-concurrence design. A concurrent prediction was also performed using the features recorded from the same 3-year stage as the predicted outcome. Machine learning algorithms, including logistic regression (LR), support vector machine (SVM), random forest (RF), and extreme gradient boosting (XGBoost), were applied to build predictive models using a unique feature set. The area under the receiver operating characteristic curve (AUC), accuracy, sensitivity, specificity, precision, and F1 score were used to evaluate the predictive performances of the models. The XGBoost model presented the best predictive performance among the non-concurrence models. This study suggests that the ensemble learning model with a MetS severity score can be used to predict the progression of osteopenia. The inclusion of an individual's features into a predictive model over time is suggested for future studies.
C1 [Cheng, Chao-Hsin] Ten Chan Gen Hosp, Div Chest Med, Taoyuan 320, Taiwan.
   [Lin, Ching-Yuan] Ten Chan Gen Hosp, Dept Lab Med, Taoyuan 320, Taiwan.
   [Cho, Tsung-Hsun] Natl Yang Ming Chiao Tung Univ, Inst Biomed Informat, Taipei 112, Taiwan.
   [Lin, Chih-Ming] Ming Chum Univ, Dept Healthcare Informat & Management, Taoyuan 333, Taiwan.
C3 National Yang Ming Chiao Tung University
RP Lin, CM (corresponding author), Ming Chum Univ, Dept Healthcare Informat & Management, Taoyuan 333, Taiwan.
EM starcheng2001@gmail.com; lab02@tcmg.com.tw; eric101784@hotmail.com;
   cmlin@mail.mcu.edu.tw
OI Lin, Chih-Ming/0000-0001-9637-395X; CHO, TSUNG-HSUN/0000-0003-1421-8943
FU Ministry of Science and Technology [MOST 109-2410-B-130-001]; Ten-Chan
   General Hospital [110001]
FX This research was funded by the Ministry of Science and Technology (MOST
   109-2410-B-130-001) and the Ten-Chan General Hospital (110001).
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NR 38
TC 3
Z9 3
U1 0
U2 2
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2227-9032
J9 HEALTHCARE-BASEL
JI Healthcare
PD AUG
PY 2021
VL 9
IS 8
AR 948
DI 10.3390/healthcare9080948
PG 15
WC Health Care Sciences & Services; Health Policy & Services
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services
GA UG3SL
UT WOS:000689176500001
PM 34442085
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Takakura, K
   Oikawa, T
   Nakano, M
   Saeki, C
   Torisu, Y
   Kajihara, M
   Saruta, M
AF Takakura, Kazuki
   Oikawa, Tsunekazu
   Nakano, Masanori
   Saeki, Chisato
   Torisu, Yuichi
   Kajihara, Mikio
   Saruta, Masayuki
TI Recent Insights Into the Multiple Pathways Driving Non-alcoholic
   Steatohepatitis-Derived Hepatocellular Carcinoma
SO FRONTIERS IN ONCOLOGY
LA English
DT Review
DE hepatocellular carcinoma; non-alcoholic steatohepatitis; non-alcoholic
   fatty liver disease; tumor necrosis factor; dysbiosis; signal transducer
   and activator of transcription
ID FATTY LIVER-DISEASE; INTESTINAL BACTERIAL OVERGROWTH;
   NECROSIS-FACTOR-ALPHA; ER STRESS; METABOLIC SYNDROME; OBESITY;
   AUTOPHAGY; CANCER; NASH; PROGRESSION
AB The incidence of metabolic syndrome with fatty liver is spreading on a worldwide scale. Correspondingly, the number of patients with the hepatic phenotype of metabolic syndrome, non-alcoholic fatty liver disease (NAFLD), and in its advanced states, non-alcoholic steatohepatitis (NASH), and the subsequent hepatocellular carcinoma (HCC) derived from NASH (NASH-HCC) is increasing remarkably. A large-scale epidemiological study revealed that obesity can be a risk factor of such cancers as HCC. Moreover, despite the ongoing trends of declining cancer incidence and mortality for most cancer types, HCC has experienced a markedly increased rate of both. Considering the differences in liver-related mortality among NAFLD patients, NASH, and NASH-HCC should be included in the objectives of initiatives to manage NAFLD patients and their progression to the advanced stages. Unfortunately, research has yet to make a crucial drug discovery for the effective treatment of NASH and NASH-HCC, although it is urgently needed. The latest widespread concept of the "multiple parallel hits hypothesis," whereby multiple factors contribute concurrently to disease pathogenesis has led to advances in the elucidation of hepatic and systemic molecular mechanisms driving NASH and the subsequent NASH-HCC progression; the results are not only extensive but promising for therapeutics. Here, we have summarized the myriad landmark discoveries of recent research into the pathogenic processes underlying NASH-HCC development and with the greatest possibility for a new generation of pharmaceutical products for interference and treatment.
C1 [Takakura, Kazuki; Oikawa, Tsunekazu; Nakano, Masanori; Saeki, Chisato; Torisu, Yuichi; Kajihara, Mikio; Saruta, Masayuki] Jikei Univ, Sch Med, Div Gastroenterol & Hepatol, Dept Internal Med, Tokyo, Japan.
C3 Jikei University
RP Takakura, K (corresponding author), Jikei Univ, Sch Med, Div Gastroenterol & Hepatol, Dept Internal Med, Tokyo, Japan.
EM ktakakura@jikei.ac.jp
RI Saruta, Masayuki/ABL-4991-2022
OI TORISU, YUICHI/0000-0002-2349-8855; Saruta, Masayuki/0000-0001-8172-3240
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NR 59
TC 29
Z9 29
U1 0
U2 9
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2234-943X
J9 FRONT ONCOL
JI Front. Oncol.
PD AUG 13
PY 2019
VL 9
AR 762
DI 10.3389/fonc.2019.00762
PG 7
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA IQ1RL
UT WOS:000480527900002
PM 31456946
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Kagota, S
   Iwata, S
   Maruyama, K
   McGuire, JJ
   Shinozuka, K
AF Kagota, Satomi
   Iwata, Saki
   Maruyama, Kana
   McGuire, John J.
   Shinozuka, Kazumasa
TI Time-Dependent Differences in the Influence of Perivascular Adipose
   Tissue on Vasomotor Functions in Metabolic Syndrome
SO METABOLIC SYNDROME AND RELATED DISORDERS
LA English
DT Article
DE mesenteric artery; metabolic syndrome; nitric oxide; perivascular
   adipose tissue; vasodilation
ID VASCULAR FUNCTION; ANIMAL-MODEL; RATS; FAT; DYSFUNCTION; DISEASE;
   STRESS; VASODILATION; INFLAMMATION; ENDOTHELIUM
AB Background: Metabolic syndrome (MetS) facilitates the development of cardiovascular disease due to atherosclerosis, which is accelerated by defects of the vascular endothelium. Vascular dysfunction in response to nitric oxide (NO) occurs in the mesenteric arteries of an animal model of MetS, SHRSP. Z-Lepr fa /IzmDmcr (SHRSP. ZF) rats. Vascular responses to vasodilators are affected by perivascular adipose tissue (PVAT) that surrounds the outsides of arteries. In this study, we assessed the role of PVAT in vascular dysfunction observed in SHRSP. ZF.
   Methods: To determine the effects of PVAT on vasodilators in SHRSP. ZF and control Wistar-Kyoto (WKY) rats, we used organ bath bioassay techniques to assay acetylcholine and nitroprusside-induced relaxations of isolated mesenteric arterial ring preparations with PVAT intact or removed.
   Results: A PVAT-mediated enhancement of relaxations induced by acetylcholine and nitroprusside occurred in SHRSP. ZF at 20 weeks of age, but not at 10 and 30 weeks, and did not occur in WKY. Furthermore, the enhancing effects of PVAT from SHRSP. ZF at 20 weeks could not be substituted by replacement with PVAT from either WKY or 30-week-old SHRSP. ZF, was inhibited by NO synthase inhibitor, and abolished by removal of the arteries' endothelium. Cyclic guanosine monophosphate (cGMP) accumulation elicited by nitroprusside was higher in SHRSP. ZF arteries with PVAT than arteries without PVAT at 20 weeks, but the enhancement of cGMP accumulation did not occur at 30 weeks.
   Conclusions: PVAT may regulate arterial tone by releasing diffusible vasorelaxing factor(s), which, through endothelium-derived NO production, compensates for impaired vasodilations at early stages of MetS.
C1 [Kagota, Satomi; Iwata, Saki; Maruyama, Kana; Shinozuka, Kazumasa] Mukogawa Womens Univ, Sch Pharm & Pharmaceut Sci, Dept Pharmacol, Nishinomiya, Hyogo, Japan.
   [McGuire, John J.] Mem Univ, Div Biomed Sci, Fac Med, St John, NF, Canada.
C3 Mukogawa Women's University; Memorial University Newfoundland
RP Kagota, S (corresponding author), 11-68 Koshien Kyuban Cho, Nishinomiya, Hyogo 6638179, Japan.
EM skagota@mukogawa-u.ac.jp
OI McGuire, John/0000-0003-0302-3884
FU MEXT KAKENHI [16K08563]; Grants-in-Aid for Scientific Research
   [16K08563] Funding Source: KAKEN
FX This work was partly supported by MEXT KAKENHI (grant number 16K08563 to
   S.K.).
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NR 37
TC 8
Z9 8
U1 0
U2 1
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-4196
EI 1557-8518
J9 METAB SYNDR RELAT D
JI Metab. Syndr. Relat. Disord.
PD JUN
PY 2017
VL 15
IS 5
BP 233
EP 239
DI 10.1089/met.2016.0146
PG 7
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA EV4JS
UT WOS:000401726400005
PM 28358621
DA 2025-06-11
ER

PT J
AU Lagos, KG
   Filippatos, TD
   Tsimihodimos, V
   Gazi, IF
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   Elisaf, MS
AF Lagos, K. G.
   Filippatos, T. D.
   Tsimihodimos, V.
   Gazi, I. F.
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   Tselepis, A. D.
   Mikhailidis, D. P.
   Elisaf, Moses S.
TI Alterations in the High Density Lipoprotein Phenotype and HDL-Associated
   Enzymes in Subjects with Metabolic Syndrome
SO LIPIDS
LA English
DT Article
DE Metabolic syndrome; High density lipoprotein; Subclasses; Lipoprotein
   associated phospholipase A(2); Paraoxonase 1; High sensitivity
   C-reactive protein; Small dense low density lipoprotein cholesterol;
   Triglycerides
ID ELEVATED OXIDATIVE STRESS; ACETYLHYDROLASE ACTIVITY; CARDIOVASCULAR
   EVENTS; PARAOXONASE ACTIVITY; CLINICAL IMPORTANCE; PHOSPHOLIPASE A(2);
   OBESE-PATIENTS; CHOLESTEROL; PARTICLES; LDL
AB Patients with metabolic syndrome (MetS) usually have low high density lipoprotein cholesterol (HDL-C) levels. We determined the HDL distribution profile as well as the HDL-related lipoprotein associated phospholipase A(2) (HDL-LpPLA(2)) and paraoxonase-1 (PON1) activities in subjects with MetS (n = 189) but otherwise healthy. Age and sex-matched individuals (n = 166) without MetS served as controls. The lower HDL-C concentration in MetS patients was due to a reduction in both large and small HDL subclasses (P < 0.001 and P < 0.05, respectively). As the number of MetS components increased, the HDL phenotype comprised of a greater percentage of small HDL-3 and less large HDL-2 subclasses, resulting in a decreased HDL-2/HDL-3 ratio (P < 0.001 for all trends). Multivariate analysis revealed that HDL-2 levels and the HDL-2/HDL-3 ratio significantly and independently correlated with HDL-C (positively) and TG (negatively) levels. HDL-3 concentration significantly and independently positively correlated with HDL-C and TG levels. HDL-LpPLA(2) activity was decreased in MetS patients (P < 0.01), a phenomenon that may contribute to the defective antiatherogenic activity of HDL in MetS. PON1 activity did not differ between groups. We conclude that MetS, in addition to the decrease in HDL-C concentration, is associated with alterations in the HDL phenotype, which is comprised of a greater percentage of small HDL subclasses. Furthermore, HDL-LpPLA(2) activity is decreased in MetS patients.
C1 [Lagos, K. G.; Tsimihodimos, V.; Gazi, I. F.; Rizos, C.; Elisaf, Moses S.] Univ Ioannina, Sch Med, Dept Internal Med, GR-45110 Ioannina, Greece.
   [Filippatos, T. D.; Mikhailidis, D. P.] UCL, Dept Clin Biochem, London, England.
   [Tselepis, A. D.] Univ Ioannina, Dept Chem, Biochem Lab, Ioannina, Greece.
C3 University of Ioannina; University of London; University College London;
   University of Ioannina
RP Elisaf, MS (corresponding author), Univ Ioannina, Sch Med, Dept Internal Med, GR-45110 Ioannina, Greece.
EM egepi@cc.uoi.gr
RI Tsimihodimos, Vasilis/AAN-9888-2021; Rizos, Christos/AAQ-5981-2020;
   Mikhailidis, Dimitri/A-1869-2013; Filippatos, Theodosios/I-6016-2016
OI ELISAF, MOSES/0000-0003-0505-078X; Tsimihodimos,
   Vasilis/0000-0003-1708-3415; Filippatos, Theodosios/0000-0002-1713-0923;
   Rizos, Christos/0000-0003-3495-9175
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NR 51
TC 64
Z9 66
U1 1
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0024-4201
EI 1558-9307
J9 LIPIDS
JI Lipids
PD JAN
PY 2009
VL 44
IS 1
BP 9
EP 16
DI 10.1007/s11745-008-3251-9
PG 8
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA 385CN
UT WOS:000261790800002
PM 18956219
DA 2025-06-11
ER

PT J
AU Icagasioglu, A
   Turgut, ST
   Atlig, RS
   Senturk, S
   Oguz, A
   Mesci, E
AF Icagasioglu, Afitap
   Turgut, Selin Turan
   Atlig, Raife Sirin
   Senturk, Senem
   Oguz, Aytekin
   Mesci, Erkan
TI IMPACTS OF OBESITY ON PAIN THRESHOLD, DEPRESSION AND QUALITY OF LIFE
SO ACTA MEDICA MEDITERRANEA
LA English
DT Article
DE Obesity; pain threshold; quality of life; depression
ID BODY-MASS INDEX; OLDER MEN; SENSITIVITY; WOMEN; RATS; POPULATION;
   ULTRASOUND; LEPTIN
AB Introduction: Obesity can effect pain threshold, emotional mood and quality of life. Differences in pain thresholds and emotional mood may have implications for pain and depression management. The aim of this study was to assess the effects of obesity on pain threshold, depression and quality of life.
   Materials and methods: This study was designed as a cross-sectional observational study and carried out on 80 adult obese and nonobese people aged between 18 and 40 years who were admitted to the obesity and metabolic syndrome outpatient clinics. The subcutaneous adipose tissue thickness was measured for rectus femoris, triceps muscle, and umbilicus by using ultrasonography. The pressure pain thresholds in 3 muscles including the deltoid, tibialis anterior, and first interosseus dorsalis muscle of the hand were measured by using a digital pressure algometer. The subjects were evaluated by visual analogue scale (VAS) when a pressure was applied on the first distal phalanx (FDP) at a rate of 25 Newton. Depression levels of the subjects were evaluated by the Beck Depression Inventory (BDI). Quality of life was evaluated by Short Form 36 (SF-36).
   Results: The mean pain threshold values showed no statistically significant difference between groups (p>0.05). The mean values of adipose thickness were significantly higher in the obese group (p<0.01). No statistically significant difference was determined between the groups in terms of FDP VAS scores (p>0.05). The obese group had significantly higher BDI scores than the control group(p<0.01). All parameters of SF-36 were significantly lower in obese individuals(p<0.01).
   Conclusions: Our findings suggest no significant correlation between obesity and pain threshold. But we found strong relationship between obesity and both for depression and quality of life
C1 [Icagasioglu, Afitap; Mesci, Erkan] Medeniyet Univ, Goztepe Training & Res Hosp, Dept Phys Med & Rehabil, Istanbul, Turkey.
   [Turgut, Selin Turan] Karaman State Hosp, Dept Phys Med & Rehabil, Karaman, Turkey.
   [Atlig, Raife Sirin] Avicenna Umut Hosp, Dept Phys Med & Rehabil, Istanbul, Turkey.
   [Senturk, Senem] Istanbul Medeniyet Univ, Goztepe Training & Res Hosp, Dept Radiol, Istanbul, Turkey.
   [Oguz, Aytekin] Medeniyet Univ, Goztepe Training & Res Hosp, Dept Internal Med, Istanbul, Turkey.
C3 Istanbul Medeniyet University; Istanbul Goztepe Training & Research
   Hospital; Karaman State Hospital; Avicenna Hospital; Istanbul Medeniyet
   University; Istanbul Goztepe Training & Research Hospital; Istanbul
   Goztepe Training & Research Hospital; Istanbul Medeniyet University
RP Icagasioglu, A (corresponding author), Istanbul Medeniyet Univ, Goztepe Training & Res Hosp, Dept Phys Med & Rehabil, Fahrettin Kerim Gokay Cad Kadikoy, Istanbul, Turkey.
RI Oguz, Aytekin/AAJ-2732-2021
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NR 30
TC 2
Z9 2
U1 0
U2 15
PU CARBONE EDITORE
PI PALERMO
PA VIA QUINTINO SELLA, 68, PALERMO, 90139, ITALY
SN 0393-6384
EI 2283-9720
J9 ACTA MEDICA MEDITERR
JI Acta Medica Mediterr.
PY 2015
VL 31
IS 1
BP 43
EP 48
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA AW5MM
UT WOS:000346319200006
DA 2025-06-11
ER

PT J
AU Seidita, A
   Soresi, M
   Giannitrapani, L
   Di Stefano, V
   Citarrella, R
   Mirarchi, L
   Cusimano, A
   Augello, G
   Carroccio, A
   Iovanna, JL
   Cervello, M
AF Seidita, Aurelio
   Soresi, Maurizio
   Giannitrapani, Lydia
   Di Stefano, Vita
   Citarrella, Roberto
   Mirarchi, Luigi
   Cusimano, Antonella
   Augello, Giuseppa
   Carroccio, Antonio
   Iovanna, Juan Lucio
   Cervello, Melchiorre
TI The clinical impact of an extra virgin olive oil enriched mediterranean
   diet on metabolic syndrome: Lights and shadows of a nutraceutical
   approach
SO FRONTIERS IN NUTRITION
LA English
DT Review
DE extra virgin olive oil (EVOO); nutraceuticals; functional foods;
   metabolic syndrome; cardiovascular disease; insulin resistance
ID NONALCOHOLIC FATTY LIVER; ENDOTHELIAL FUNCTION; PHENOLIC-COMPOUNDS;
   HEPATIC STEATOSIS; OXIDATIVE STRESS; HEALTHY-SUBJECTS; LIPID PROFILE;
   STYLE DIET; FACTOR-VII; POLYPHENOLS
AB For years it has been established that the only truly effective treatment of metabolic syndrome (MS) is lifestyle modification to prevent its cardiovascular (e.g., coronary artery disease and atherosclerosis), metabolic (e.g., diabetes mellitus), and hepatic (e.g., steatosis and non-alcoholic steatohepatitis) complications. The focal points of this approach are to increase physical activity and intake of a diet characterized by high quantities of fruits, vegetables, grains, fish, and low-fat dairy products, the so called mediterranean diet (MD); however, the added value of MD is the presence of extra virgin olive oil (EVOO), a healthy food with a high content of monounsaturated fatty acids, especially oleic acid, and variable concentrations (range 50-800 mg/kg) of phenols (oleuropein, ligstroside, and oleocanthal, and their derivatives, phenolic alcohols, such as hydroxytyrosol and tyrosol). Phenolic compounds not only determine EVOO's main organoleptic qualities (oxidative stability, specific flavor, and taste features) but, theoretically, make it a source of antioxidant, anti-inflammatory, insulin-sensitizing, cardioprotective, antiatherogenic, neuroprotective, immunomodulatory, and anticancer activity. Although many studies have been carried out on EVOO's clinical effects and attention toward this dietary approach (healthy and palatable food with strong nutraceutical activity) has become increasingly pressing, there are still many dark sides to be clarified, both in terms of actual clinical efficacy and biochemical and molecular activity. Thus, we reviewed the international literature, trying to show the state of the art about EVOO's clinical properties to treat MS (along with correlated complications) and the future prospective of its nutraceutical use.
C1 [Seidita, Aurelio; Soresi, Maurizio; Giannitrapani, Lydia; Citarrella, Roberto; Mirarchi, Luigi] Univ Palermo, Dept Hlth Promot Sci Maternal & Infant Care Inter, Unit Internal Med, Palermo, Italy.
   [Giannitrapani, Lydia; Cusimano, Antonella; Augello, Giuseppa; Cervello, Melchiorre] CNR, Inst Biomed Res & Innovat IRIB, Palermo, Italy.
   [Di Stefano, Vita] Univ Palermo, Dept Biol Chem & Pharmaceut Sci & Technol STEBICE, Palermo, Italy.
   [Carroccio, Antonio] Osped Riuniti Villa Sofia Cervello, Unit Internal Med, V Cervello Hosp, Palermo, Italy.
   [Carroccio, Antonio] Univ Palermo, Dept Hlth Promot Sci Maternal & Infant Care Inter, Palermo, Italy.
   [Iovanna, Juan Lucio] Aix Marseille Univ, CNRS, Inst Paoli Calmettes, Canc Res Ctr Marseille,INSERM,CRCM, Marseille, France.
C3 University of Palermo; Consiglio Nazionale delle Ricerche (CNR);
   Istituto Ricerca l'Innovazione Biomedica (IRIB-CNR); University of
   Palermo; University of Palermo; UNICANCER; Institut Paoli-Calmette
   (IPC); Centre National de la Recherche Scientifique (CNRS); Institut
   National de la Sante et de la Recherche Medicale (Inserm); Aix-Marseille
   Universite
RP Cervello, M (corresponding author), CNR, Inst Biomed Res & Innovat IRIB, Palermo, Italy.
EM melchiorre.cervello@irib.cnr.it
RI Giannitrapani, Lydia/I-3706-2019; Cervello, Melchiorre/K-5080-2016; Di
   stefano, Vita/G-6889-2013; Seidita, Aurelio/IQT-5629-2023
OI Di Stefano, Vita/0000-0002-4483-2058; Augello,
   Giuseppa/0000-0001-6073-2789; Seidita, Aurelio/0000-0003-4080-2641
FU University of Palermo;  [08TP1041100162];  [IRIS/U GOV 16463]
FX This work was supported in part by the project n. 08TP1041100162 named
   TRIAL "Code IRIS/U GOV 16463" "PO FESR Sicilia 2014-2020" to LG.
   Publication costs supported in part by the FFR2021 fund of the
   University of Palermo assigned to MS.
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NR 102
TC 18
Z9 18
U1 0
U2 5
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD AUG 4
PY 2022
VL 9
AR 980429
DI 10.3389/fnut.2022.980429
PG 13
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA M0LO5
UT WOS:001027117400001
PM 35990331
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Cabrera, AG
   Caballero, P
   Wanden-Berghe, C
   Sanz-Lorente, M
   López-Pintor, E
AF Gea Cabrera, Alicia
   Caballero, Pablo
   Wanden-Berghe, Carmina
   Sanz-Lorente, Maria
   Lopez-Pintor, Elsa
TI Effectiveness of Workplace-Based Diet and Lifestyle Interventions on
   Risk Factors in Workers with Metabolic Syndrome: A Systematic Review,
   Meta-Analysis and Meta-Regression
SO NUTRIENTS
LA English
DT Article
DE metabolic syndrome; occupational health; workplace; diet; food and
   nutrition; systematic review
ID PUBLICATION BIAS; HEALTH; PROGRAM; MANAGEMENT; DISEASE; IMPACT;
   ASSOCIATION; POPULATION; DEFINITION; PREVALENCE
AB Workplace health interventions are essential to improve the health and well-being of workers and promote healthy lifestyle behaviours. We carried out a systematic review, meta-analysis and meta-regression of articles measuring the association between workplace dietary interventions and MetS risk. We recovered potentially eligible studies by searching MEDLINE, the Cochrane Library, Embase, Scopus and Web of Science, using the terms "Metabolic syndrome" and "Occupational Health". A total of 311 references were retrieved and 13 documents were selected after applying the inclusion and exclusion criteria. Dietary interventions were grouped into six main types: basic education/counselling; specific diet/changes in diet and food intake; behavioural change/coaching; physical exercise; stress management; and internet/social networks. Most programmes included several components. The interventions considered together are beneficial, but the clinical results reflect only a minimal impact on MetS risk. According to the metaregression, the interventions with the greatest impact were those that used coaching techniques and those that promoted physical activity, leading to increased HDL (effect size = 1.58, sig = 0.043; and 2.02, 0.015, respectively) and decreased BMI (effect size = -0.79, sig = -0.009; and -0.77, 0.034, respectively). In contrast, interventions offering information on healthy habits and lifestyle had the contrary effect, leading to increased BMI (effect size = 0.78, sig = 0.006), systolic blood pressure (effect size = 4.85, sig = 0.038) and diastolic blood pressure (effect size = 3.34, sig = 0.001). It is necessary to improve the efficiency of dietary interventions aimed at lowering MetS risk in workers.
C1 [Gea Cabrera, Alicia; Lopez-Pintor, Elsa] Univ Miguel Hernandez, Dept Engn, Area Pharm & Pharmaceut Technol, Alicante 03550, Spain.
   [Caballero, Pablo] Univ Alicante, Dept Community Nursing Prevent Med & Publ Hlth &, Alicante 03690, Spain.
   [Wanden-Berghe, Carmina] Hosp Gen Univ Alicante, Grp Nutr Clin, Alicante 03010, Spain.
   [Wanden-Berghe, Carmina] Hosp Gen Univ Alicante, HAD, Inst Invest Sanit & Biomed Alicante ISABIA, Fdn FISABIO, Alicante 03010, Spain.
   [Sanz-Lorente, Maria] Univ Miguel Hernandez, Dept Publ Hlth & Hist Sci, Alicante 03550, Spain.
   [Lopez-Pintor, Elsa] CIBERESP, CIBER Epidemiol & Publ Hlth, Madrid 28029, Spain.
C3 Universidad Miguel Hernandez de Elche; Universitat d'Alacant; General
   University Hospital of Alicante; General University Hospital of
   Alicante; Universidad Miguel Hernandez de Elche; CIBER - Centro de
   Investigacion Biomedica en Red; CIBERESP
RP López-Pintor, E (corresponding author), Univ Miguel Hernandez, Dept Engn, Area Pharm & Pharmaceut Technol, Alicante 03550, Spain.; López-Pintor, E (corresponding author), CIBERESP, CIBER Epidemiol & Publ Hlth, Madrid 28029, Spain.
EM ali_ftca@hotmail.com; pablo.caballero@ua.es; carminaw@telefonica.net;
   msanzlor@gmail.com; elsa.lopez@umh.es
RI Caballero, Pablo/H-6457-2019
OI Caballero, Pablo/0000-0002-1234-2150; LOPEZ-PINTOR,
   ELSA/0000-0003-0937-5725
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NR 69
TC 16
Z9 17
U1 1
U2 9
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD DEC
PY 2021
VL 13
IS 12
AR 4560
DI 10.3390/nu13124560
PG 31
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA XX9WW
UT WOS:000736637200001
PM 34960112
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Hao, H
   Guo, H
   Ma, RL
   Yan, YZ
   Hu, YH
   Ma, JL
   Zhang, XH
   Wang, XP
   Wang, K
   Mu, LT
   Song, YP
   Zhang, JY
   He, J
   Guo, SX
AF Hao, Hao
   Guo, Heng
   Ma, Ru-lin
   Yan, Yi-zhong
   Hu, Yun-hua
   Ma, Jiao-long
   Zhang, Xiang-hui
   Wang, Xin-ping
   Wang, Kui
   Mu, La-ti
   Song, Yan-peng
   Zhang, Jing-yu
   He, Jia
   Guo, Shu-xia
TI Association of total bilirubin and indirect bilirubin content with
   metabolic syndrome among Kazakhs in Xinjiang
SO BMC ENDOCRINE DISORDERS
LA English
DT Article
DE Bilirubin; Transaminase; Metabolic syndrome
ID ALANINE AMINOTRANSFERASE; DISEASE; STRESS; PLASMA; RISK; MEN
AB Background Some studies have shown that a high level of bilirubin is a protective factor against metabolic syndrome (MS), while a high level of transaminase is a risk factor for MS. However, the existing results are inconsistent and few cohort studies have been published. Methods Using an ambispective cohort study, 565 Kazakhs from Xinjiang, China were selected as the study subjects. The baseline serum bilirubin and transaminase levels of the subjects were divided into quartiles and the relationship between these values and the incidence of MS was analyzed. The definition of MS was based on the Joint Interim Statement (JIS) diagnostic criteria. Results The average follow-up time for the subjects was 5.72 years. The cumulative incidence of MS was 36.11% (204 of the 565 subjects), and the incidence density was 63.10/1000 person-years. Multivariate Cox regression analysis showed that the levels of total bilirubin (TBIL) and indirect bilirubin (IBIL) were negatively correlated with the occurrence of MS, Compared to the lowest quartile level (Q1), the hazard ratios of MS the TBIL levels at the Q2-Q4 quartiles were: 0.47 (0.31-0.71), 0.53 (0.35-0.79), and 0.48 (0.32-0.72), respectively, while IBIL levels at the Q2-Q4 quartiles showed an MS hazard ratio of 0.48 (0.32-0.72), 0.54(0.36-0.81), and 0.52 (0.35-0.77), respectively, all at a 95% confidence level. However, no relationship was found between transaminase levels and the incidence of MS. Conclusion Serum TBIL and IBIL levels were negatively correlated with the incidence of MS in a Kazakh population in China.
C1 [Hao, Hao; Guo, Heng; Ma, Ru-lin; Yan, Yi-zhong; Hu, Yun-hua; Ma, Jiao-long; Zhang, Xiang-hui; Wang, Xin-ping; Wang, Kui; Mu, La-ti; Song, Yan-peng; Zhang, Jing-yu; He, Jia; Guo, Shu-xia] Shihezi Univ, Dept Publ Hlth, Sch Med, Shihezi 832000, Xinjiang, Peoples R China.
   [Song, Yan-peng] Shihezi Univ, Affiliated Hosp 1, Coll Med, Shihezi 832000, Xinjiang, Peoples R China.
   [Guo, Shu-xia] Shihezi Univ, Sch Med, Minist Educ, Dept Pathol, Shihezi 832000, Xinjiang, Peoples R China.
   [Guo, Shu-xia] Shihezi Univ, Sch Med, Minist Educ, Key Lab Xinjiang Endem & Ethn Dis, Shihezi 832000, Xinjiang, Peoples R China.
C3 Shihezi University; Shihezi University; Ministry of Education - China;
   Shihezi University; Shihezi University; Ministry of Education - China
RP He, J; Guo, SX (corresponding author), Shihezi Univ, Dept Publ Hlth, Sch Med, Shihezi 832000, Xinjiang, Peoples R China.
EM hejia123.shihezi@163.com; gsxshzu@sina.com
RI Zhang, Jingyu/HOF-5633-2023; Guo, Shuxia/Y-4219-2018
OI Yan, Yizhong/0000-0003-1957-5421; Zhang, XiangHui/0000-0002-1829-1681
FU National Natural Science Foundation of China [81560551]; Shihezi
   University Innovation Outstanding Young Talents Program (Natural
   Science) [CXPY201908]
FX This study was funded by the National Natural Science Foundation of
   China (no. 81560551) and the Shihezi University Innovation Outstanding
   Young Talents Program (Natural Science) (no. CXPY201908). The funders
   played no role in the design of this study, the collection, analysis and
   interpretation of data or preparation of the manuscript.
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NR 37
TC 11
Z9 12
U1 0
U2 5
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1472-6823
J9 BMC ENDOCR DISORD
JI BMC Endocr. Disord.
PD JUL 22
PY 2020
VL 20
IS 1
AR 110
DI 10.1186/s12902-020-00563-y
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA MT5WH
UT WOS:000555044800003
PM 32698889
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Moreno-Viedma, V
   Amor, M
   Sarabi, A
   Bilban, M
   Staffler, G
   Zeyda, M
   Stulnig, M
AF Moreno-Viedma, V.
   Amor, M.
   Sarabi, A.
   Bilban, M.
   Staffler, G.
   Zeyda, M.
   Stulnig, M.
TI Common dysregulated pathways in obese adipose tissue and atherosclerosis
SO CARDIOVASCULAR DIABETOLOGY
LA English
DT Article
DE Cardiovascular diseases; Diabetes mellitus; type 2; Insulin resistance;
   Atherosclerosis; Pathway analysis
ID INSULIN-RESISTANCE; OXIDATIVE STRESS; RT-PCR; INFLAMMATION; MICROARRAY;
   GENES; EXPRESSION; PROTEINS; BIOLOGY
AB Background: The metabolic syndrome is becoming increasingly prevalent in the general population that is at simultaneous risk for both type 2 diabetes and cardiovascular disease. The critical pathogenic mechanisms underlying these diseases are obesity-driven insulin resistance and atherosclerosis, respectively. To obtain a better understanding of molecular mechanisms involved in pathogenesis of the metabolic syndrome as a basis for future treatment strategies, studies considering both inherent risks, namely metabolic and cardiovascular, are needed. Hence, the aim of this study was to identify pathways commonly dysregulated in obese adipose tissue and atherosclerotic plaques.
   Methods: We carried out a gene set enrichment analysis utilizing data from two microarray experiments with obese white adipose tissue and atherosclerotic aortae as well as respective controls using a combined insulin resistance-atherosclerosis mouse model.
   Results: We identified 22 dysregulated pathways common to both tissues with p values below 0.05, and selected inflammatory response and oxidative phosphorylation pathways from the Hallmark gene set to conduct a deeper evaluation at the single gene level. This analysis provided evidence of a vast overlap in gene expression alterations in obese adipose tissue and atherosclerosis with Il7r, C3ar1, Tlr1, Rgs1 and Semad4d being the highest ranked genes for the inflammatory response pathway and Maob, Bckdha, Aldh6a1, Echs1 and Cox8a for the oxidative phosphorylation pathway.
   Conclusions: In conclusion, this study provides extensive evidence for common pathogenic pathways underlying obesity-driven insulin resistance and atherogenesis which could provide a basis for the development of novel strategies to simultaneously prevent type 2 diabetes and cardiovascular disease in patients with metabolic syndrome.
C1 [Moreno-Viedma, V.; Amor, M.; Sarabi, A.; Zeyda, M.; Stulnig, M.] Med Univ Vienna, Christian Doppler Lab Cardiometabol Immunotherapy, Waehringer Guertel 18-20, A-1090 Vienna, Austria.
   [Moreno-Viedma, V.; Amor, M.; Sarabi, A.; Zeyda, M.; Stulnig, M.] Med Univ Vienna, Clin Div Endocrinol & Metab, Dept Med 3, Waehringer Guertel 18-20, A-1090 Vienna, Austria.
   [Bilban, M.] Med Univ Vienna, Dept Lab Med, Vienna, Austria.
   [Bilban, M.] Med Univ Vienna, Core Facil Genom, Core Facil, Vienna, Austria.
   [Staffler, G.] AFFiRiS AG, Vienna, Austria.
   [Zeyda, M.] Med Univ Vienna, Dept Pediat & Adolescent Med, Clin Div Pediat Pulmonol Allergol & Endocrinol, Vienna, Austria.
C3 Medical University of Vienna; Medical University of Vienna; Medical
   University of Vienna; Medical University of Vienna; Medical University
   of Vienna
RP Stulnig, M (corresponding author), Med Univ Vienna, Christian Doppler Lab Cardiometabol Immunotherapy, Waehringer Guertel 18-20, A-1090 Vienna, Austria.; Stulnig, M (corresponding author), Med Univ Vienna, Clin Div Endocrinol & Metab, Dept Med 3, Waehringer Guertel 18-20, A-1090 Vienna, Austria.
EM thomas.stulnig@meduniwien.ac.at
RI Amor, Melina/AAF-3276-2021; Moreno-Viedma, Verónica/AAC-8685-2022
OI Moreno-Viedma, Veronica/0000-0003-0906-8725; Moreno Viedma,
   Veronica/0000-0003-1934-1692; Zeyda, Maximilian/0000-0001-5000-1974;
   Stulnig, Thomas/0000-0003-3300-6161; Bilban, Martin/0000-0001-7043-7142;
   Amor, Melina/0000-0002-2799-5322
FU Federal Ministry of Economy, Family and Youth; National Foundation for
   Research, Technology and Development
FX This work was supported by the Federal Ministry of Economy, Family and
   Youth and the National Foundation for Research, Technology and
   Development. (to T.M.S.).
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NR 44
TC 40
Z9 45
U1 0
U2 6
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1475-2840
J9 CARDIOVASC DIABETOL
JI Cardiovasc. Diabetol.
PD AUG 26
PY 2016
VL 15
AR 120
DI 10.1186/s12933-016-0441-2
PG 12
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism
GA DW7NP
UT WOS:000383838100001
PM 27561966
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Kapravelou, G
   Martínez, R
   Andrade, AM
   Nebot, E
   Camiletti-Moirón, D
   Aparicio, VA
   Lopez-Jurado, M
   Aranda, P
   Arrebola, F
   Fernandez-Segura, E
   Bermano, G
   Goua, M
   Galisteo, M
   Porres, JM
AF Kapravelou, Garyfallia
   Martinez, Rosario
   Andrade, Ana M.
   Nebot, Elena
   Camiletti-Moiron, Daniel
   Aparicio, Virginia A.
   Lopez-Jurado, Maria
   Aranda, Pilar
   Arrebola, Francisco
   Fernandez-Segura, Eduardo
   Bermano, Giovanna
   Goua, Marie
   Galisteo, Milagros
   Porres, Jesus M.
TI Aerobic interval exercise improves parameters of nonalcoholic fatty
   liver disease (NAFLD) and other alterations of metabolic syndrome in
   obese Zucker rats
SO APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
LA English
DT Article
DE metabolic syndrome; nonalcoholic fatty liver disease; aerobic interval
   training; aerobic capacity; lipid metabolism; hepatic metabolic
   pathways; liver antioxidant status
ID CONTINUOUS MODERATE EXERCISE; OXIDATIVE STRESS; INSULIN-RESISTANCE;
   INTENSITY; DIET; STEATOHEPATITIS; EXPRESSION; MUSCLE; ATHEROSCLEROSIS;
   DYSFUNCTION
AB Metabolic syndrome (MS) is a group of metabolic alterations that increase the susceptibility to cardiovascular disease and type 2 diabetes. Nonalcoholic fatty liver disease has been described as the liver manifestation of MS. We aimed to test the beneficial effects of an aerobic interval training (AIT) protocol on different biochemical, microscopic, and functional liver alterations related to the MS in the experimental model of obese Zucker rat. Two groups of lean and obese animals (6 weeks old) followed a protocol of AIT (4 min at 65%-80% of maximal oxygen uptake, followed by 3 min at 50%-65% of maximal oxygen uptake for 45-60 min, 5 days/week, 8 weeks of experimental period), whereas 2 control groups remained sedentary. Obese rats had higher food intake and body weight (P < 0.0001) and suffered significant alterations in plasma lipid profile, area under the curve after oral glucose overload (P < 0.0001), liver histology and functionality, and antioxidant status. The AIT protocol reduced the severity of alterations related to glucose and lipid metabolism and increased the liver protein expression of PPAR gamma, as well as the gene expression of glutathione peroxidase 4 (P < 0.001). The training protocol also showed significant effects on the activity of hepatic antioxidant enzymes, although this action was greatly influenced by rat phenotype. The present data suggest that AIT protocol is a feasible strategy to improve some of the plasma and liver alterations featured by the MS.
C1 [Kapravelou, Garyfallia; Martinez, Rosario; Andrade, Ana M.; Nebot, Elena; Camiletti-Moiron, Daniel; Aparicio, Virginia A.; Lopez-Jurado, Maria; Aranda, Pilar; Porres, Jesus M.] Univ Granada, Inst Nutr & Food Technol, Dept Physiol, Doctoral Program Nutr & Food Sci, E-18071 Granada, Spain.
   [Arrebola, Francisco; Fernandez-Segura, Eduardo] Univ Granada, Dept Histol, Inst Neurosci, E-18071 Granada, Spain.
   [Bermano, Giovanna; Goua, Marie] Robert Gordon Univ, Inst Hlth & Wellbeing Res, Aberdeen AB10 7GJ, Scotland.
   [Galisteo, Milagros] Univ Granada, Sch Pharm, Dept Pharmacol, E-18071 Granada, Spain.
C3 University of Granada; University of Granada; Robert Gordon University;
   University of Granada
RP Porres, JM (corresponding author), Univ Granada, Inst Nutr & Food Technol, Dept Physiol, Doctoral Program Nutr & Food Sci, Campus Univ Cartuja S-N, E-18071 Granada, Spain.
EM jmporres@ugr.es
RI Camiletti-Moirón, Daniel/Q-7424-2016; Arrebola Vargas,
   Francisco/L-9108-2014; Fernandezsegura, Eduardo/F-3756-2016; Goua,
   Marie/J-8104-2019; Martinez, Rosario/K-7712-2017; Kapravelou,
   Garyfallia/K-8635-2017; Aranda Ramirez, Pilar/B-8037-2016; Aparicio,
   Virginia A/D-9666-2016; Nebot Valenzuela, Elena/M-2561-2014; Porres
   Foulquie, Jesus Maria/B-6442-2018
OI Martinez, Rosario/0000-0003-2032-1621; Kapravelou,
   Garyfallia/0000-0001-8414-9723; Aranda Ramirez,
   Pilar/0000-0002-7982-1359; Bermano, Giovanna/0000-0001-6027-6437;
   Aparicio, Virginia A/0000-0002-2867-378X; Nebot Valenzuela,
   Elena/0000-0001-9689-6945; Goua, Marie/0000-0003-1609-4366; Porres
   Foulquie, Jesus Maria/0000-0001-5657-0764; Camiletti Moiron,
   Daniel/0000-0002-8856-5967
FU Junta de Andalucia, Spain [P09-AGR-4658]; Institute for Health and
   Wellbeing Research; European Union [AGL2013-43247-R]
FX We want to thank Encarnacion Rebollo and Lucia Bustos for skillful
   technical assistance. This study was funded by grant P09-AGR-4658 from
   Junta de Andalucia, Spain, and is part of the PhD thesis of Garyfallia
   Kapravelou, entitled "Effects of legume protein hydrolyzates on lipid
   metabolism in an obese rat experimental model. Interaction with aerobic
   physical exercise." Gene expression work was carried out at Robert
   Gordon University and was funded by the Institute for Health and
   Wellbeing Research. The authors also want to acknowledge the Ministry of
   Economy and Competitiveness (MINECO, Spain) and the European Union
   through project no. AGL2013-43247-R and FEDER program, respectively.
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NR 69
TC 28
Z9 30
U1 1
U2 29
PU CANADIAN SCIENCE PUBLISHING
PI OTTAWA
PA 65 AURIGA DR, SUITE 203, OTTAWA, ON K2E 7W6, CANADA
SN 1715-5312
EI 1715-5320
J9 APPL PHYSIOL NUTR ME
JI Appl. Physiol. Nutr. Metab.
PD DEC
PY 2015
VL 40
IS 12
BP 1242
EP 1252
DI 10.1139/apnm-2015-0141
PG 11
WC Nutrition & Dietetics; Physiology; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics; Physiology; Sport Sciences
GA CY3VH
UT WOS:000366337500003
PM 26509584
OA Green Accepted, Green Submitted
DA 2025-06-11
ER

PT J
AU Nagase, M
   Fujita, T
AF Nagase, Miki
   Fujita, Toshiro
TI Aldosterone and glomerular podocyte injury
SO CLINICAL AND EXPERIMENTAL NEPHROLOGY
LA English
DT Review
DE proteinuria; chronic kidney disease; metabolic syndrome; oxidative
   stress; salt; mineralocorticoid receptor activation; aldosterone
   releasing factors
ID CHRONIC KIDNEY-DISEASE; BODY-MASS INDEX; ANGIOTENSIN-CONVERTING ENZYME;
   ACTIVATED PROTEIN-KINASE; METABOLIC SYNDROME; PLASMA-ALDOSTERONE; NADPH
   OXIDASE; MINERALOCORTICOID RECEPTOR; NATRIURETIC PEPTIDE;
   CELL-PROLIFERATION
AB Aldosterone is traditionally viewed as a hormone regulating electrolyte and blood pressure homeostasis by acting on the distal nephron. Accumulating evidence suggests that aldosterone also plays pathogenetic roles in cardiovascular and renal injury. For example, aldosterone is a potent inducer of proteinuria. We demonstrated that podocyte injury underlies the pathogenesis of proteinuria in aldosterone-infused rats on a high salt diet. Mineralocorticoid receptor was detected in the podocytes in vivo and in vitro, and aldosterone caused induction of its effector kinase Sgk1, activation of NADPH oxidase and generation of reactive oxygen species. Selective aldosterone blocker eplerenone, as well as antioxidant tempol, ameliorated aldosterone-induced podocyte injury and proteinuria. Aldosterone was also involved in the podocyte damage and proteinuria of metabolic syndrome model SHR/NDmcr-cp. Adipocyte-derived aldosterone releasing factors were suggested to contribute to the aldosterone excess of this model. Furthermore, high salt diet markedly worsened the renal injury of SHR/NDmcr-cp. Although salt lowered serum aldosterone levels, it caused MR activation in the kidney. Accordingly, eplerenone dramatically improved the salt-evoked nephropathy. Taken together, aldosterone blockers can be an excellent therapeutic strategy for the treatment of podocyte injury, proteinuria, and cardiovascular and renal complications, not only in high aldosterone states but also in patients with activated MR signaling in the target tissue, whose circulating aldosterone level is not necessarily high. Addition of aldosterone blockers in patients treated with ACEIs or ARBs are also promising, because of "aldosterone breakthrough'' phenomenon. Careful monitoring of hyperkalemia is necessary, especially in patients with impaired renal function.
C1 [Nagase, Miki; Fujita, Toshiro] Univ Tokyo, Grad Sch Med, Dept Nephrol & Endocrinol, Bunkyo Ku, Tokyo 1138655, Japan.
C3 University of Tokyo
RP Nagase, M (corresponding author), Univ Tokyo, Grad Sch Med, Dept Nephrol & Endocrinol, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1138655, Japan.
EM mnagase-tky@umin.ac.jp
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NR 110
TC 63
Z9 67
U1 1
U2 8
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1342-1751
EI 1437-7799
J9 CLIN EXP NEPHROL
JI Clin. Exp. Nephrol.
PD AUG
PY 2008
VL 12
IS 4
BP 233
EP 242
DI 10.1007/s10157-008-0034-9
PG 10
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 343IN
UT WOS:000258846900001
PM 18317876
DA 2025-06-11
ER

PT J
AU Aradhyula, V
   Waigi, E
   Bearss, NR
   Edwards, JM
   Joe, B
   McCarthy, CG
   Koch, LB
   Wenceslau, CF
AF Aradhyula, Vaishnavi
   Waigi, Emily
   Bearss, Nicole R.
   Edwards, Jonnelle M.
   Joe, Bina
   McCarthy, Cameron G.
   Koch, Lauren B.
   Wenceslau, Camilla F.
TI Intrinsic exercise capacity induces divergent vascular plasticity via
   arachidonic acid-mediated inflammatory pathways in female rats
SO VASCULAR PHARMACOLOGY
LA English
DT Article
DE Test
ID ENDOTHELIAL DYSFUNCTION; HYPERPOLARIZING FACTOR; OXIDATIVE STRESS;
   AEROBIC CAPACITY; SMALL ARTERIES; LIPOXIN
AB Metabolic syndrome prevalence has increased among US adults, particularly among non-hispanic white and black women. Sedentary behavior often leads to chronic inflammation, a triggering factor of metabolic syndrome. Given that intrinsic exercise capacity is genetically inherited, we questioned if low-grade chronic inflammation would be present in a female rat model of low intrinsic exercise capacity-induced metabolic syndrome, while beneficial increase of resolution of inflammation would be present in a female rat model of high intrinsic exercise capacity. In the vascular system, two primary markers for inflammation and resolution of inflammation are cyclooxygenase (COX) and lipoxygenase (LOX), respectively. Our study focused on the novel hypothesis that untrained, inherited exercise capacity induces divergent vascular plasticity via changes in the delicate balance between COX and LOX inflammatory mediators. We used divergent rat strains with low (LCR) and high (HCR) aerobic running capacity. By using animals with contrasting intrinsic exercise capacities, it is possible to determine the exact triggers that lead to inherited vascular plasticity in female rats. We observed that female LCR displayed increased periovarian fat pad and body weight, which is congruent with their obesity-presenting phenotype. Furthermore, LCR presented with vascular hypocontractility and increased COX and LOX-derived pro-inflammatory factors. On the other hand, HCR presented with a "shutdown" of COX-induced vasoconstriction and enhanced resolution of inflammation to maintain vascular tone and homeostasis. In conclusion, LCR display low-grade chronic inflammation via increased COX activity. These results provide mechanistic clues as to why lower intrinsic aerobic capacity correlates with a predisposition to risk of vascular disease. Conversely, being born with higher intrinsic aerobic capacity is a significant factor for improved vascular physiology in female rats.
C1 [Aradhyula, Vaishnavi; Waigi, Emily; Bearss, Nicole R.; Edwards, Jonnelle M.; Joe, Bina; McCarthy, Cameron G.; Koch, Lauren B.; Wenceslau, Camilla F.] Univ Toledo, Dept Physiol & Pharmacol, Coll Med & Life Sci, 2801 W Bancroft St, Toledo, OH 43606 USA.
C3 University System of Ohio; University of Toledo
RP Wenceslau, CF (corresponding author), Univ Toledo, Dept Physiol & Pharmacol, Coll Med & Life Sci, Lab Vasc Biol LVB, 3000 Transverse Dr, Toledo, OH 43614 USA.
EM Camilla.Wenceslau@utoledo.edu
FU National Institutes of Health [R01HL149762, R00GM118885, K99HL151889,
   R01HL1430820]; American Heart Association [18POST34060003]; NSF
   [AGEP1432878]; Office of Research Infrastructure Programs [P40OD021331];
   Department of Physiology & Pharmacology, University of Toledo College of
   Medicine, Toledo, OH; National Heart Lung and Blood Institute
   [K99HL151889] Funding Source: NIH RePORTER; National Institute of
   General Medical Sciences [R00GM118885] Funding Source: NIH RePORTER
FX This work was supported by National Institutes of Health (R01HL149762
   and R00GM118885 to C.F.W., K99HL151889 to C.G.M., R01HL1430820 to B.J.),
   American Heart Association (18POST34060003 to C.G.M.) and NSF
   (AGEP1432878 to J.M.E.). The LCR and HCR rat model system was funded by
   the Office of Research Infrastructure Programs grant (P40OD021331 to
   L.G.K.). The rat models for low and high exercise capacity are
   maintained as an international resource with support from the Department
   of Physiology & Pharmacology, University of Toledo College of Medicine,
   Toledo, OH. Contact LGKLauren.Koch2@UToledo.Edu for information on the
   rat models.
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NR 48
TC 1
Z9 2
U1 0
U2 2
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1537-1891
EI 1879-3649
J9 VASC PHARMACOL
JI Vasc. Pharmacol.
PD OCT
PY 2021
VL 140
AR 106862
DI 10.1016/j.vph.2021.106862
EA SEP 2021
PG 10
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA WK0GC
UT WOS:000709412300005
PM 33872803
OA Green Accepted, Bronze
DA 2025-06-11
ER

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AF Chou, Chu-Lin
   Li, Ching-Hao
   Lin, Heng
   Liao, Mei-Hui
   Wu, Chin-Chen
   Chen, Jin-Shuen
   Sue, Yuh-Mou
   Fang, Te-Chao
TI Role of activating transcription factor 3 in fructose-induced metabolic
   syndrome in mice
SO HYPERTENSION RESEARCH
LA English
DT Article; Proceedings Paper
CT Annual Meeting and Conference of the Taiwan-Society-of-Internal-Medicine
CY DEC 02-03, 2017
CL Taipei, TAIWAN
SP Taiwan Soc Internal Med
ID HYPERINSULINEMIA-INDUCED HYPERTENSION; INSULIN-RESISTANCE; FED RATS;
   VASCULAR DYSFUNCTION; LIPID HOMEOSTASIS; OXIDATIVE STRESS; ATF3;
   EXPRESSION; DIET; STEATOSIS
AB Activating transcription factor 3 (ATF3) has been implicated in cardiovascular disease and inflammation. This study examined the effects of ATF3 knockout (KO) on blood pressure, glucose intolerance, dyslipidemia, inflammation, and visceral adiposity in mice fed who did and did not consume a high-fructose diet. Male mice were divided into four groups (N = 15 for each group): the Con (control) group (wild-type mice fed a standard chow diet), Fru group (wild-type mice fed a high-fructose [60% fructose] diet), ATF3KO-Con group (ATF3 KO mice fed a standard chow diet), and ATF3KO-Fru group (ATF3 KO mice fed a high-fructose [60% fructose] diet). Experiments were conducted for 8 weeks. Our data demonstrated that ATF3 KO mice have lower systolic blood pressure (SBP) levels than do wild-type mice, and that high-fructose diets increase SBP levels in both wild-type and ATF3 KO mice. ATF3 KO in mice increased the serum levels of glucose, insulin, triglycerides, tumor necrosis factor-alpha, and intercellular adhesion molecule-1, impaired endothelium-dependent aortic relaxation, increased aorta wall thickness and lipid peroxide, and expanded visceral adiposity. These symptoms resembled those exhibited by the wild-type mice fed a high-fructose diet, which caused hyperglycemia, insulin resistance, dyslipidemia, endothelium-dependent aortic dysfunction, inflammation, aorta remodeling, and visceral adiposity. A high-fructose diet among ATF3 KO mice deteriorated metabolic parameters and inflammatory cytokines. The present results therefore suggest that ATF3 deficiency is involved in the pathogenesis of metabolic syndrome and ATF3 might have a therapeutic role in fructose-induced impairment of endothelium-dependent aortic relaxation, a rising of inflammatory cytokines, and metabolic syndrome.
C1 [Chou, Chu-Lin; Chen, Jin-Shuen] Natl Def Med Ctr, Div Nephrol, Dept Internal Med, Triserv Gen Hosp, Taipei, Taiwan.
   [Li, Ching-Hao; Lin, Heng] Taipei Med Univ, Sch Med, Dept Physiol, Coll Med, Taipei, Taiwan.
   [Li, Ching-Hao] Taipei Med Univ, Grad Inst Med Sci, Coll Med, Taipei, Taiwan.
   [Lin, Heng] Taipei Med Univ, Coll Pharm, Taipei, Taiwan.
   [Liao, Mei-Hui; Wu, Chin-Chen] Natl Def Med Ctr, Grad Inst Med Sci, Taipei, Taiwan.
   [Sue, Yuh-Mou] Taipei Med Univ, Wan Fang Hosp, Div Nephrol, Dept Internal Med, Taipei, Taiwan.
   [Sue, Yuh-Mou; Fang, Te-Chao] Taipei Med Univ, Sch Med, Div Nephrol, Dept Internal Med, Taipei, Taiwan.
   [Fang, Te-Chao] Taipei Med Univ, Taipei Med Univ Hosp, Div Nephrol, Dept Internal Med, Taipei, Taiwan.
C3 Tri-Service General Hospital; National Defense Medical Center; Taipei
   Medical University; Taipei Medical University; Taipei Medical
   University; National Defense Medical Center; Taipei Medical University;
   Taipei Municipal WanFang Hospital; Taipei Medical University; Taipei
   Medical University Hospital; Taipei Medical University
RP Sue, YM (corresponding author), Taipei Med Univ, Wan Fang Hosp, Div Nephrol, Dept Internal Med, Taipei, Taiwan.; Sue, YM; Fang, TC (corresponding author), Taipei Med Univ, Sch Med, Div Nephrol, Dept Internal Med, Taipei, Taiwan.; Fang, TC (corresponding author), Taipei Med Univ, Taipei Med Univ Hosp, Div Nephrol, Dept Internal Med, Taipei, Taiwan.
EM sueym@tmu.edu.tw; fangtechao@gmail.com
RI CHEN, JUI-YI/AAV-8854-2021; Liu, Chun-Yu/I-4358-2015
OI Chou, Chu-Lin/0000-0002-9695-1067
FU Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan [105
   TMU-WFH-06]; Taipei Medical University [TMU103-AE1-B30]; Ministry of
   Science and Technology, Taiwan [MOST 105-2314-B-038-024]
FX This work was supported by Wan Fang Hospital, Taipei Medical University,
   Taipei, Taiwan (105 TMU-WFH-06; funds for Y-MS), by Taipei Medical
   University (TMU103-AE1-B30; funds for T-CF) and by Ministry of Science
   and Technology, Taiwan (MOST 105-2314-B-038-024; funds for T-CF). The
   funder had no role in study design, data collection and analysis,
   publication decision, or manuscript preparation.
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NR 30
TC 12
Z9 13
U1 0
U2 5
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0916-9636
EI 1348-4214
J9 HYPERTENS RES
JI Hypertens. Res.
PD AUG
PY 2018
VL 41
IS 8
BP 589
EP 597
DI 10.1038/s41440-018-0058-9
PG 9
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Cardiovascular System & Cardiology
GA GP3ZS
UT WOS:000440795800007
PM 29895822
DA 2025-06-11
ER

PT J
AU Francisqueti, FV
   Minatel, IO
   Ferron, AJT
   Bazan, SGZ
   Silva, VD
   Garcia, JL
   de Campos, DHS
   Ferreira, AL
   Moreto, F
   Cicogna, AC
   Corrêa, CR
AF Francisqueti, Fabiane Valentini
   Minatel, Igor Otavio
   Togneri Ferron, Artur Junio
   Zanati Bazan, Silmeia Garcia
   Silva, Vanessa dos Santos
   Garcia, Jessica Leite
   Salome de Campos, Dijon Henrique
   Ferreira, Ana Lucia
   Moreto, Fernando
   Cicogna, Antonio Carlos
   Correa, Camila Renata
TI Effect of Gamma-Oryzanol as Therapeutic Agent to Prevent Cardiorenal
   Metabolic Syndrome in Animals Submitted to High Sugar-Fat Diet
SO NUTRIENTS
LA English
DT Article
DE high sugar-fat diet; obesity; cardiac dysfunction; renal disease;
   gamma-oryzanol; Cardiorenal Metabolic Syndrome
ID RICE BRAN OIL; INSULIN-RESISTANCE; OXIDATIVE STRESS; KIDNEY INJURY;
   OBESITY; COMPONENTS; DYSLIPIDEMIA; HYPERTENSION; GLUCOSE; MODEL
AB Background: The high consumption of fat and sugar contributes to the development of obesity and co-morbidities, such as diabetes, and cardiovascular and kidney diseases. Different strategies have been used to prevent these diseases associated with obesity, such as changes in eating habits and/or the addition of dietary components with anti-inflammatory and anti-oxidant properties, such as gamma-oryzanol (Oz) present mainly in bran layers and rice germ. Methods: Animals were randomly divided into four experimental groups and fed ad libitum for 20 weeks with control diet (C, n = 8), control diet + Oz (C + Oz, n = 8), high-sugar and high-fat diet (HSF, n = 8), and high-sugar and high-fat diet + Oz (HSF + Oz, n = 8). HSF groups also received water + sucrose (25%). The dose of Oz was added to diets to reach 0.5% of final concentration (w/w). Evaluation in animals included food and caloric intake, body weight, plasma glucose, insulin, triglycerides, uric acid, HOMA-IR, glomerular filtration rate, protein/creatinine ratio, systolic blood pressure, and Doppler echocardiographic. Results: Animals that consumed the HSF diet had weight gain compared to group C, increased insulin, HOMA, glucose and triglycerides, there were also atrial and ventricular structural alterations, deterioration of systolic and diastolic function, decreased glomerular filtration rate, and proteinuria. Gamma-oryzanol is significantly protective against effects on body weight, hypertriglyceridemia, renal damage, and against structural and functional alteration of the heart. Conclusion: Gamma-oryzanol shows potential as a therapeutic to prevent Cardiorenal Metabolic Syndrome.
C1 [Francisqueti, Fabiane Valentini; Togneri Ferron, Artur Junio; Zanati Bazan, Silmeia Garcia; Silva, Vanessa dos Santos; Garcia, Jessica Leite; Salome de Campos, Dijon Henrique; Ferreira, Ana Lucia; Moreto, Fernando; Cicogna, Antonio Carlos; Correa, Camila Renata] Sao Paulo State Univ Unesp, Sch Med, BR-18618687 Botucatu, SP, Brazil.
   [Minatel, Igor Otavio] Sao Paulo State Univ Unesp, Inst Biosci, BR-18618689 Botucatu, SP, Brazil.
C3 Universidade Estadual Paulista; Universidade Estadual Paulista
RP Corrêa, CR (corresponding author), Sao Paulo State Univ Unesp, Sch Med, BR-18618687 Botucatu, SP, Brazil.
EM fabiane_vf@yahoo.com.br; igorminatel@hotmail.com;
   artur.ferron@gmail.com; sgzanati@fmb.unesp.br; vangynera@gmail.com;
   jessleitegarcia@gmail.com; dijoncampos@gmail.com; ferreira@fmb.unesp.br;
   fer_moreto@yahoo.com.br; cicogna@fmb.unesp.br; ccorrea@fmb.unesp.br
RI Silva, Vanessa/JXX-4985-2024; Correa, Camila/Q-2071-2019; Zanati-Bazan,
   Silmeia/F-3177-2012; Minatel, Igor/A-9094-2016; Francisqueti,
   Fabiane/AAY-8977-2020; Moreto, Fernando/I-7690-2013; Leite Garcia,
   Jessica/Q-8779-2018; Ferron, Artur Junio/M-5194-2017; Francisqueti-
   Ferron, Fabiane/M-4919-2017
OI Moreto, Fernando/0000-0002-4028-0014; Correa, Camila
   Renata/0000-0001-8493-5329; Leite Garcia, Jessica/0000-0002-3670-243X;
   Ferron, Artur Junio/0000-0001-7089-3033; Francisqueti- Ferron,
   Fabiane/0000-0003-2910-4308; Zanati Bazan, Silmeia
   Garcia/0000-0002-0607-8189; Cicogna, Antonio Carlos/0000-0002-4402-6523
FU Fundacao de Amparo a Pesquisa do Estado de Sao Paulo-FAPESP
   [2015/10626-0]
FX This work was funded by Fundacao de Amparo a Pesquisa do Estado de Sao
   Paulo-FAPESP (2015/10626-0).
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NR 47
TC 45
Z9 47
U1 0
U2 10
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 2072-6643
J9 NUTRIENTS
JI Nutrients
PD DEC
PY 2017
VL 9
IS 12
AR 1299
DI 10.3390/nu9121299
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA FR6PQ
UT WOS:000419188600025
PM 29186059
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Quesada-López, T
   González-Dávalos, L
   Piña, E
   Mora, O
AF Quesada-Lopez, Tania
   Gonzalez-Davalos, Laura
   Pina, Enrique
   Mora, Ofelia
TI HSD1 and AQP7 short-term gene regulation by cortisone in 3T3-L1
   adipocytes
SO ADIPOCYTE
LA English
DT Article
DE 3T3-L1 cells; Aqp7; cortisone; Hsd1; metabolic syndrome
ID 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1; VISCERAL ADIPOSE-TISSUE;
   METABOLIC SYNDROME; AQUAPORIN ADIPOSE; CENTRAL OBESITY; EXPRESSION;
   GLUCOCORTICOIDS; STRESS; TRANSPORT; DEXAMETHASONE
AB Adipose Tissue (AT) is a complex organ with a crucial regulatory role in energy metabolism and in the development of obesity and the Metabolic Syndrome (MS). Modified responses and the metabolism of hormones have been observed in visceral adiposity during obesity, specifically as related with cortisone. The objective of this study was to assess, in the 3T3-L1 adipocyte cell line, the short-term effect of cortisone on the expression of 11-Hydroxysteroid dehydrogenase 1 (Hsd1), which is responsible for activation of cortisone into cortisol, and for Aquaporin 7 (Aqp7), involved in glycerol transport through the cell membrane. Total RNA (tRNA) and complementary DNA (cDNA) were obtained from cell samples treated with cortisone (0.1, 1, and 10M) during different times (0, 5, 10, 15, and 20min, and 48h) to quantify the expression of the aforementioned genes by real time PCR employing MnSOD and Ppia as housekeeping genes. There was a time-dependent response of Aqp7, a dose-dependent response of Hsd1, and an increase observed in the expression of both genes during min 1 of treatment (5- and 6-fold, respectively), followed by a decrease during the following 5-10min (P < 0.05). With the 1-M cortisone treatment, both genes showed cubic tendencies in their expression; the Hsd1 tendency is described by the equation y = 0.18x(3)-1.65x(2)+3.59x+1.31, while the Aqp7 tendency is described by y = 0.33x(3)-2.67x(2)+4.93x+1.84. There are immediate and quantitatively important actions of cortisone on the expression of Aqp7 and Hsd1 in 3T3-L1 adipocytes.
C1 [Quesada-Lopez, Tania] Univ Autonoma Queretaro, Fac Ciencias Nat, Nutr, Juriquilla, Mexico.
   [Gonzalez-Davalos, Laura; Mora, Ofelia] UNAM, FES Cuautitlan, Lab Rumiol & Metab Nutr RuMeN, Secretaria Posgrad, Blvd Juriquilla 3001, Juriquilla 76230, Queretaro, Mexico.
   [Pina, Enrique] UNAM, Fac Med, Dept Bioquim, Juriquilla, Queretaro, Mexico.
C3 Universidad Autonoma de Queretaro; Universidad Nacional Autonoma de
   Mexico; Universidad Nacional Autonoma de Mexico
RP Mora, O (corresponding author), UNAM, FES Cuautitlan, Lab Rumiol & Metab Nutr RuMeN, Secretaria Posgrad, Blvd Juriquilla 3001, Juriquilla 76230, Queretaro, Mexico.
EM ofemora66@unam.mx
RI Quesada Lopez, Tania Paloma/L-6690-2018
OI Quesada Lopez, Tania Paloma/0000-0002-7818-4351; Mora,
   Ofelia/0000-0002-7073-7740; Pina, Enrique/0000-0003-2436-9956
FU CONACYT (Mexico); PAPIIT-UNAM [IN218112]
FX T. Quesada thanks CONACYT (Mexico) for a scholarship at FESC-UNAM. The
   authors received a research grant from PAPIIT-UNAM (IN218112).
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NR 37
TC 4
Z9 4
U1 0
U2 3
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 2162-3945
EI 2162-397X
J9 ADIPOCYTE
JI Adipocyte
PY 2016
VL 5
IS 3
BP 298
EP 305
DI 10.1080/21623945.2016.1187341
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA DV9HA
UT WOS:000383250100005
PM 27617175
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Damirchi, A
   Tehrani, BS
   Alamdari, KA
   Babaei, P
AF Damirchi, Arsalan
   Tehrani, Bahram Soltani
   Alamdari, Karim Azali
   Babaei, Parvin
TI Influence of Aerobic Training and Detraining on Serum BDNF, Insulin
   Resistance, and Metabolic Risk Factors in Middle-Aged Men Diagnosed With
   Metabolic Syndrome
SO CLINICAL JOURNAL OF SPORT MEDICINE
LA English
DT Article
DE aerobic training and detraining; BDNF; metabolic syndrome
ID OXIDATIVE STRESS MARKERS; NEUROTROPHIC FACTOR BDNF; POSTMENOPAUSAL
   WOMEN; PHYSICAL-ACTIVITY; REDUCTION INTERVENTION; POSTPRANDIAL LIPEMIA;
   DEFINED EXERCISE; RAT-BRAIN; OBESITY; LIPOPROTEINS
AB Objective: To study the influence of aerobic exercise training on brain-derived neurotrophic factor (BDNF), insulin resistance, and lipid profile in middle-aged men diagnosed with metabolic syndrome (MetS).
   Design: This is an experimental repeated measure study.
   Setting: Subjects participated in aerobic training programs (18 sessions of 25-40 minutes per session) in Guilan University gymnasium and court.
   Participants: A total of 21 middle-aged men (50-65 years old) diagnosed with MetS participated.
   Interventions: We randomly divided 21 middle-aged men with MetS into exercise and control groups. The exercise group followed an aerobic training program (18 sessions, 3/wk) at 50% to 60% of (V) over dotO(2) peak (25-40 minutes per session) and 6 weeks of detraining. Blood samples were collected at baseline, end of the training, and detraining.
   Main Outcome Measures: High BDNF level in patients with MetS and its reduction after chronic aerobic exercise.
   Results: Aerobic training significantly decreased all the metabolic risk factors, including overall MetS z score, insulin resistance, and lipid profile (P < 0.05). After the detraining period, plasma triglyceride, high-density lipoprotein, and also overall MetS z score remained unchanged (P < 0.05); however, serum BDNF, which was decreased by aerobic training (P = 0.013), restored to the baseline at the end of the detraining (P = 0.018).
   Conclusions: Improved metabolic risk factors along with decreased serum BDNF in response to aerobic training and the opposite direction during the detraining emphasize the importance of physical activity in the treatment of MetS and prevention of related diseases.
C1 [Damirchi, Arsalan] Univ Guilan, Fac Phys Educ & Sport Sci, Dept Sport Physiol, Rasht, Iran.
   [Tehrani, Bahram Soltani; Babaei, Parvin] Guilan Univ Med Sci, Cellular & Mol Res Ctr, Rasht, Iran.
   [Alamdari, Karim Azali] Azarbaijan Shahid Madani Univ, Fac Psychol & Educ, Dept Phys Educ & Sport Sci, Tabriz, Iran.
   [Babaei, Parvin] Guilan Univ Med Sci, Dept Physiol, Rasht, Iran.
C3 University of Guilan; Guilan University of Medical Sciences; Azarbaijan
   Shahid Madani University; Guilan University of Medical Sciences
RP Babaei, P (corresponding author), Guilan Univ Med Sci, Fac Med, Dept Physiol, Cellular & Mol Res Ctr, POB 3363, Rasht, Iran.
EM p_babaei@gums.ac.ir
RI Alamdari, Karim/IYS-3087-2023; babaei, parvin/ABB-8760-2021; Tehrani,
   Bahram/S-9078-2017; Damirchi, Arsalan/HPD-7498-2023; babaei,
   parvin/H-5269-2017
OI soltani tehrani, bahram/0000-0003-2685-8606; azali alamdari,
   karim/0000-0002-6134-1912; damirchi, arsalan/0000-0002-3442-0631;
   babaei, parvin/0000-0003-4870-8182
FU Research Council of the University of Guilan
FX Supported by grants from the Research Council of the University of
   Guilan.
CR [Anonymous], JAMA
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NR 51
TC 39
Z9 40
U1 0
U2 16
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1050-642X
EI 1536-3724
J9 CLIN J SPORT MED
JI Clin. J. Sport Med.
PD NOV
PY 2014
VL 24
IS 6
BP 513
EP 518
PG 6
WC Orthopedics; Physiology; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Physiology; Sport Sciences
GA AT2AM
UT WOS:000344733000016
PM 24662570
DA 2025-06-11
ER

PT J
AU Ghazizadeh, H
   Khorasani, MY
   Shabani, N
   Sahranavard, T
   Zare-Feyzabadi, R
   Mohammadi-Bajgiran, M
   Timar, A
   Oladi, MR
   Moazedi, S
   Mosalman-Zadeh, N
   Khedmatgozar, H
   Rohban, M
   Hasanzadeh, E
   Javandoost, A
   Nazarpour, S
   Bahrami, A
   Ferns, GA
   Haghdoost, AA
   Esmaily, H
   Ghayour-Mobarhan, M
AF Ghazizadeh, Hamideh
   Khorasani, Mahdiyeh Yaghooti
   Shabani, Niloofar
   Sahranavard, Toktam
   Zare-Feyzabadi, Reza
   Mohammadi-Bajgiran, Maryam
   Timar, Ameneh
   Oladi, Mohammad Reza
   Moazedi, Sara
   Mosalman-Zadeh, Negin
   Khedmatgozar, Hamed
   Rohban, Mohadeseh
   Hasanzadeh, Elahe
   Javandoost, Ali
   Nazarpour, Shahin
   Bahrami, Afsane
   Ferns, Gordon A.
   Haghdoost, Ali Akbar
   Esmaily, Habibollah
   Ghayour-Mobarhan, Majid
TI Relationship Between Clinical, Demographic and Socioeconomic Factors
   with Suicide Ideation; A Cross-sectional Study
SO COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING
LA English
DT Article
DE Suicide ideation; clinical parameters; demographic factors;
   socio-economic factors; MCHC; FBG
ID PHYSICAL-ACTIVITY; METABOLIC SYNDROME; IRON-METABOLISM; CYTOKINE LEVELS;
   RISK-FACTORS; ASSOCIATION; DEPRESSION; BEHAVIOR; SMOKING; BLOOD
AB Background: Suicide has grown in global prevalence as a public health problem. We aimed to evaluate the association of socioeconomic factors, biochemical and hematologic tests, and suicide ideation. Methods: In this cross-sectional study, 8267 Iranian adults aged 35 - 65 years old were enrolled. The assessment of suicide ideation was made by the completion of Beck's depression inventory (BDI) questionnaire; according to one specific item on the questionnaire: "have you ever decided to suicide in the past week?" Results: According to our results, 6.9% of subjects had ideation of suicide. The results showed high levels of FBG, RBC, MCHC, and hs-CRP were associated with suicide ideation. Obese, single subjects, and current-smokers had a higher risk of suicide ideation. Conclusion: Increased physical activity, obesity, and smoking are associated with a high risk of suicide ideation; whilst, a high MCHC is related to a low risk of suicide ideation in Iranian adults.
C1 [Ghazizadeh, Hamideh] Mashhad Univ Med Sci, Student Res Comm, Mashhad, Razavi Khorasan, Iran.
   [Ghazizadeh, Hamideh; Zare-Feyzabadi, Reza; Mohammadi-Bajgiran, Maryam; Timar, Ameneh; Oladi, Mohammad Reza; Khedmatgozar, Hamed; Rohban, Mohadeseh; Hasanzadeh, Elahe; Javandoost, Ali; Nazarpour, Shahin; Ghayour-Mobarhan, Majid] Mashhad Univ Med Sci, Int UNESCO Ctr Hlth Related Basic Sci & Human Nut, Mashhad, Razavi Khorasan, Iran.
   [Khorasani, Mahdiyeh Yaghooti; Shabani, Niloofar; Sahranavard, Toktam; Ghayour-Mobarhan, Majid] Mashhad Univ Med Sci, Metab Syndrome Res Ctr, Mashhad, Razavi Khorasan, Iran.
   [Moazedi, Sara; Mosalman-Zadeh, Negin] Varastegan Inst Med Sci, Dept Nutr Sci, Mashhad, Razavi Khorasan, Iran.
   [Khedmatgozar, Hamed] Texas Tech Univ, Ctr Biotechnol & Genom, Lubbock, TX 79409 USA.
   [Bahrami, Afsane] Mashhad Univ Med Sci, Imam Reza Hosp, Clin Res Dev Unit, Fac Med, Mashhad, Razavi Khorasan, Iran.
   [Bahrami, Afsane] Mashhad Univ Med Sci, Akbar Hosp, Fac Med, Clin Res Dev Unit, Mashhad, Razavi Khorasan, Iran.
   [Ferns, Gordon A.] Brighton & Sussex Med Sch, Div Med Educ, Brighton, Sussex, England.
   [Haghdoost, Ali Akbar] Kerman Univ Med Sci, Modeling Hlth Res Ctr, Kerman, Iran.
   [Esmaily, Habibollah] Mashhad Univ Med Sci, Social Determinants Hlth Res Ctr, Mashhad, Razavi Khorasan, Iran.
C3 Mashhad University of Medical Sciences; Mashhad University of Medical
   Sciences; Mashhad University of Medical Sciences; Texas Tech University
   System; Texas Tech University; Mashhad University of Medical Sciences;
   Mashhad University of Medical Sciences; University of Sussex; University
   of Brighton; Kerman University of Medical Sciences; Mashhad University
   of Medical Sciences
RP Ghayour-Mobarhan, M (corresponding author), Mashhad Univ Med Sci, Int UNESCO Ctr Hlth Related Basic Sci & Human Nut, Mashhad, Razavi Khorasan, Iran.; Ghayour-Mobarhan, M (corresponding author), Mashhad Univ Med Sci, Metab Syndrome Res Ctr, Mashhad, Razavi Khorasan, Iran.; Esmaily, H (corresponding author), Mashhad Univ Med Sci, Social Determinants Hlth Res Ctr, Mashhad, Razavi Khorasan, Iran.
EM esmaily@mums.ac.ir; ghayourm@mums.ac.ir
RI Ghayour-Mobarhan, Majid/AAY-5963-2020; Sahranavard,
   Toktam/AGK-9166-2022; Hasanzadeh, Elahe/AAL-4486-2021; Ghazizadeh,
   Hamideh/ABE-8941-2020; bahrami, afsaneh/Q-3369-2018; Haghdoost,
   Ali/C-2823-2009
OI Hasanzadeh, Elahe/0000-0002-4764-9638; Yaghooti Khorasani,
   Mahdiyeh/0000-0001-5110-0851; Sahranavard, Toktam/0000-0001-6446-7783;
   Bahrami, Afsane/0000-0002-4563-6112
FU Mashhad University of Medical Sciences, Mashhad, Iran [85134]
FX Research reported in this publication was supported by the Mashhad
   University of Medical Sciences, Mashhad, Iran (85134)
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NR 71
TC 2
Z9 2
U1 0
U2 2
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1386-2073
EI 1875-5402
J9 COMB CHEM HIGH T SCR
JI Comb. Chem. High Throughput Screen
PY 2022
VL 25
IS 6
BP 1047
EP 1057
DI 10.2174/1386207324666210302094438
PG 11
WC Biochemical Research Methods; Chemistry, Applied; Pharmacology &
   Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry; Pharmacology & Pharmacy
GA 3U1AP
UT WOS:000840702400008
PM 33653243
DA 2025-06-11
ER

PT J
AU Moriarity, DP
   Kautz, MM
   Giollabhui, NM
   Klugman, J
   Coe, CL
   Ellman, LM
   Abramson, LY
   Alloy, LB
AF Moriarity, Daniel P.
   Kautz, Marin M.
   Giollabhui, Naoise Mac
   Klugman, Joshua
   Coe, Christopher L.
   Ellman, Lauren M.
   Abramson, Lyn Y.
   Alloy, Lauren B.
TI Bidirectional Associations Between Inflammatory Biomarkers and
   Depressive Symptoms in Adolescents: Potential Causal Relationships
SO CLINICAL PSYCHOLOGICAL SCIENCE
LA English
DT Article
DE affective disorders; causal analysis; causality; depression; health
ID C-REACTIVE PROTEIN; CHILDRENS DEPRESSION; SOCIOECONOMIC-STATUS;
   METABOLIC SYNDROME; CYTOKINES; METAANALYSIS; CHILDHOOD; INVENTORY;
   SICKNESS; PSYCHOPATHOLOGY
AB There are inconsistent findings in the literature about the directionality and magnitude of the association between inflammation and depressive symptoms. This analysis separates predictors into between-persons and within-person components to gain greater clarity about this relationship. Blood samples were collected and depressive symptoms assessed in 140 adolescents (54% female, 59% Black; mean age = 16.1 years) with at least three blood draws and a total of 394 follow-up observations. Multilevel modeling indicated that the within-persons effect of tumor necrosis factor alpha predicted change in total depressive symptoms, which suggests a potential causal relationship. There were no significant within-persons effects of total depressive symptoms on change in biomarkers. Exploratory analyses examined associations between inflammatory biomarkers and subsets of depressive symptoms. These findings inform modeling decisions that may explain inconsistencies in the extant literature as well as suggest potential causal relationships between certain proteins with significant within-persons effects on depressive symptoms and vice-versa.
C1 [Moriarity, Daniel P.; Kautz, Marin M.; Giollabhui, Naoise Mac; Klugman, Joshua; Ellman, Lauren M.; Alloy, Lauren B.] Temple Univ, Dept Psychol, Weiss Hall,1701 N 13th St, Philadelphia, PA 19122 USA.
   [Coe, Christopher L.; Abramson, Lyn Y.] Univ Wisconsin, Dept Psychol, 1202 W Johnson St, Madison, WI 53706 USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE); Temple
   University; University of Wisconsin System; University of Wisconsin
   Madison
RP Alloy, LB (corresponding author), Temple Univ, Dept Psychol, Weiss Hall,1701 N 13th St, Philadelphia, PA 19122 USA.
EM lalloye@temple.edu
RI Moriarity, Daniel/AAV-8535-2020; Mac Giollabhui, Naoise/J-4768-2019;
   Klugman, Joshua/H-8300-2013
OI P. Moriarity, Daniel/0000-0001-8678-7307; Mac Giollabhui,
   Naoise/0000-0003-4226-5704; Klugman, Joshua/0000-0002-7072-0041
FU National Institute of Mental Health [MH079369, MH101168]; National
   Institute of Mental Health Research Service Award [F31MH122116];
   National Science Foundation [2018263024]; National Institute of Mental
   Health Research Service [F31MH118808]
FX This research was supported by National Institute of Mental Health
   Grants MH079369 and MH101168 (to L. B. Alloy). D. P. Moriarity was
   supported by National Institute of Mental Health Research Service Award
   F31MH122116. M. M. Kautz was supported by National Science Foundation
   Graduate Research Fellowship 2018263024. N. Mac Giollabhui was supported
   by National Institute of Mental Health Research Service Award
   F31MH118808.
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NR 62
TC 45
Z9 49
U1 0
U2 15
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 2167-7026
EI 2167-7034
J9 CLIN PSYCHOL SCI
JI Clin. Psychol. Sci.
PD JUL
PY 2020
VL 8
IS 4
BP 690
EP 703
AR 2167702620917458
DI 10.1177/2167702620917458
EA MAY 2020
PG 14
WC Psychology, Clinical; Psychiatry; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA MJ8BK
UT WOS:000534112500001
PM 32724728
OA Green Submitted, Green Accepted
DA 2025-06-11
ER

PT J
AU Wang, KJ
   Zhou, ZH
   Huang, L
   Kan, QH
   Wang, ZC
   Wu, WB
   Yao, C
AF Wang, Kangjie
   Zhou, Zhihao
   Huang, Lin
   Kan, Qinghui
   Wang, Zhecun
   Wu, Weibin
   Yao, Chen
TI PINK1 dominated mitochondria associated genes signature predicts
   abdominal aortic aneurysm with metabolic syndrome
SO BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
LA English
DT Article
DE Mitochondria; Abdominal aortic aneurysm; Metabolic syndrome; Machine
   learning; Nomoscore
ID PERIPHERAL ARTERIAL-DISEASE; ATHEROSCLEROSIS; INFLAMMATION;
   PATHOGENESIS; MACROPHAGES; MECHANISMS; STRESS
AB Abdominal aortic aneurysm (AAA) is typically asymptomatic but a devastating cardiovascular disorder, with overall mortality exceeding 80 % once it ruptures. Some patients with AAA may also have comorbid metabolic syndrome (MS), suggesting a potential common underlying pathogenesis. Mitochondrial dysfunction has been reported as a key factor contributing to the deterioration of both AAA and MS. However, the intricate interplay between metabolism and mitochondrial function, both contributing to the development of AAA, has not been thoroughly explored.In this study, we identified candidate genes related to mitochondrial function in AAA and MS. Subsequently, we developed a nomoscore model comprising hub genes (PINK1, ACSL1, CYP27A1, and SLC25A11), identified through the application of two machine learning algorithms, to predict AAA. We observed a marked disparity in immune infiltration profiles between high-and low-nomoscore groups. Furthermore, we confirmed a significant upregulation of the expression of the four hub genes in AAA tissues. Among these, ACSL1 showed relatively higher expression in LPS-treated RAW264.7 cell lines, while CYP27A1 exhibited a notable decrease. Moreover, SLC25A11 displayed a significant upregulation in AngII-treated VSMCs. Conversely, the expression level of PINK1 declined in LPS-stimulated RAW264.7 cell lines but significantly increased in AngII-treated VSMCs. In vivo experiments revealed that the activation of PINK1-mediated mitophagy inhibited the development of AAA in mice.In this current study, we have innovatively identified four mitochondrial function-related genes through in-tegrated bioinformatic analysis. This discovery sheds light on the regulatory mechanisms and unveils promising therapeutic targets for the comorbidity of AAA and MS.
C1 [Wang, Kangjie; Zhou, Zhihao; Huang, Lin; Kan, Qinghui; Wang, Zhecun; Wu, Weibin; Yao, Chen] Sun Yat Sen Univ, Affiliated Hosp 1, Div Vasc Surg, Guangzhou 510080, Peoples R China.
   [Wang, Kangjie; Zhou, Zhihao; Huang, Lin; Kan, Qinghui] Sun Yat sen Univ, Affiliated Hosp 1, Natl Guangdong Joint Engn Lab Diag & Treatment Vas, Guangzhou 510080, Peoples R China.
C3 Sun Yat Sen University; Sun Yat Sen University
RP Wang, ZC; Wu, WB; Yao, C (corresponding author), Sun Yat Sen Univ, Affiliated Hosp 1, Div Vasc Surg, Guangzhou 510080, Peoples R China.
EM wangzhc7@mail.sysu.edu.cn; wuweib@mail2.sysu.edu.cn;
   yaochen@mail.sysu.edu.cn
RI Wang, Kangjie/GQH-4238-2022; wang, zhecun/GWM-5103-2022; Wu,
   Weibin/AAJ-6174-2020; Huang, Lin/M-2262-2019; Yao, Chen/JVD-6226-2023
FU National Natural Science Founda-tion of China [82070495, 82200544,
   82200542]; Natural Science Foundation of Guangdong Provincial
   [2023A1515011602]; Postdoctoral Science Foundation of China
   [2022M723645]
FX <B>Funding</B> This study was supported by the National Natural Science
   Founda-tion of China (grant numbers: 82070495, 82200544 and 82200542) ,
   the Natural Science Foundation of Guangdong Provincial (2023A1515011602)
   , the Postdoctoral Science Foundation of China (2022M723645) .
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NR 65
TC 3
Z9 3
U1 0
U2 6
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0925-4439
EI 1879-260X
J9 BBA-MOL BASIS DIS
JI Biochim. Biophys. Acta-Mol. Basis Dis.
PD FEB
PY 2024
VL 1870
IS 2
AR 166919
DI 10.1016/j.bbadis.2023.166919
EA NOV 2023
PG 15
WC Biochemistry & Molecular Biology; Biophysics; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Cell Biology
GA Z9FA5
UT WOS:001115045700001
PM 38251428
OA hybrid
DA 2025-06-11
ER

PT J
AU Widmer, A
   Mercante, MG
   Silver, HJ
AF Widmer, Annaliese
   Mercante, Margaret G.
   Silver, Heidi J.
TI TG/HDL Ratio Is an Independent Predictor for Estimating Resting Energy
   Expenditure in Adults with Normal Weight, Overweight, and Obesity
SO NUTRIENTS
LA English
DT Article
DE insulin resistance; obesity; resting energy expenditure; TG; HDL ratio
ID INSULIN-RESISTANCE; METABOLIC-RATE; MITOCHONDRIAL DYSFUNCTION; OXIDATIVE
   STRESS; BODY-COMPOSITION; TRIGLYCERIDE; GLUCOSE; ASSOCIATIONS;
   CHOLESTEROL; LIVER
AB Factors that determine resting energy expenditure (REE) remain under investigation, particularly in persons with a high body mass index (BMI). The accurate estimation of energy expenditure is essential for conducting comprehensive nutrition assessments, planning menus and meals, prescribing weight and chronic disease interventions, and the prevention of malnutrition. This study aimed to: (a) determine the contribution of cardiometabolic biomarkers to the inter-individual variation in REE in persons categorized by BMI; and (b) assess the contribution of these biomarkers in the prediction of REE when persons of varying BMI status were categorized by their glycemic and metabolic syndrome status. Baseline data from 645 adults enrolled in diet intervention trials included REE measured by indirect calorimetry, body composition by dual energy X-ray absorptiometry, anthropometrics, and cardiometabolic biomarkers. Multivariate linear regression modeling was conducted to determine the most parsimonious model that significantly predicted REE by BMI category, metabolic syndrome status, and glycemic status. Modeling with the traditional predictors (age, sex, height, weight) accounted for 58-63% of the inter-individual variance in REE. When including age, sex, height, weight and fat-free mass as covariates, adding TG/HDL to regression modeling accounted for 71-87% of the variance in REE. The finding that TG/HDL is an independent predictor in estimating REE was further confirmed when participants were categorized by metabolic syndrome status and by glycemic status. The clinical utility of calculating the TG/HDL ratio not only aids health care providers in identifying patients with impaired lipid metabolism but can optimize the estimation of REE to better meet therapeutic goals for weight and disease management.
C1 [Widmer, Annaliese; Silver, Heidi J.] Vanderbilt Univ, Dept Med, Med Ctr, Nashville, TN 37232 USA.
   [Mercante, Margaret G.] Vanderbilt Univ, Coll Arts & Sci, Nashville, TN 37212 USA.
   [Silver, Heidi J.] Tennessee Valley Healthcare Syst, Dept Vet Affairs, Nashville, TN 37212 USA.
C3 Vanderbilt University; Vanderbilt University; US Department of Veterans
   Affairs; Veterans Health Administration (VHA); VA Tennessee Valley
   Healthcare System
RP Silver, HJ (corresponding author), Vanderbilt Univ, Dept Med, Med Ctr, Nashville, TN 37232 USA.; Silver, HJ (corresponding author), Tennessee Valley Healthcare Syst, Dept Vet Affairs, Nashville, TN 37212 USA.
EM heidi.j.silver@vumc.org
OI Silver, Heidi/0000-0003-2237-4903; , Margaret/0000-0002-3376-1864;
   Widmer, Annaliese/0000-0002-4647-3589
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NR 47
TC 3
Z9 4
U1 0
U2 2
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD DEC
PY 2022
VL 14
IS 23
AR 5106
DI 10.3390/nu14235106
PG 15
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 6X6NF
UT WOS:000896527600001
PM 36501139
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Lai, CH
   Huang, RJ
   Wong, JKS
   Chang, SW
   Chung, AH
   Chi, YC
   Yu, YC
   Lee, SD
   Ting, H
AF Lai, Ching-Hsiang
   Huang, Ren-Jing
   Wong, James Kok-Suh
   Chang, Shen-Wen
   Chung, Ai-Hui
   Chi, Yung-Chun
   Yu, Yi-Chen
   Lee, Shin-Da
   Ting, Hua
TI Confounded by obesity and modulated by urinary uric acid excretion,
   sleep-disordered breathing indirectly relates to hyperuricaemia in
   males: A structural equation model
SO JOURNAL OF SLEEP RESEARCH
LA English
DT Article
DE hepatic dysfunction; metabolic syndrome; obstructive sleep apnea; renal
   dysfunction
ID AIRWAY PRESSURE THERAPY; METABOLIC SYNDROME; SERUM URATE; APNEA;
   DISEASE; FITNESS; METAANALYSIS; ASSOCIATION; REDUCTION; HYPOXEMIA
AB Sleep-disordered breathing (SDB) causes hypoxic stress and can trigger uric acid (UA) overproduction. We comprehensively investigated whether SDB, interacting with components of metabolic syndrome, hepatic and renal dysfunctions, low physical fitness, sedentary lifestyle, disrupted sleep, and chronic systemic inflammation (CSI), is directly associated with hyperuricaemia. In 528 community-based males (mean [SD] age 46.2 [7.4] years), we cross-sectionally analysed measures of anthropometry; self-reported lifestyle habits; overnight sleep polysomnography data; cardiopulmonary exercise tests; and biomarkers of cardiometabolic, hepatic, and renal functions; and CSI, using structural equation modelling. Objective disrupted sleep, C-reactive protein, low physical fitness, and sedentary lifestyle were not related to UA levels in univariate analysis and were excluded. The latent variables (with corresponding manifest variables) obesity (body mass index, waist-hip ratio), hypertension (post-sleep systolic, diastolic blood pressure), dyslipidaemia (total cholesterol, triglyceride/high-density lipoprotein cholesterol), hepatic dysfunction (alanine aminotransferase, aspartate transaminase), and renal dysfunction (blood urea nitrogen, serum creatinine) were positively; and hyperglycaemia (fasting glucose, glycated haemoglobin) was negatively associated with hyperuricaemia (serum UA), except for SDB (Apnea-Hypopnea Index, percentage of oxygen saturation <90% period against total sleep time, oxygen desaturation index) in the one-stage influence model. In the two-stage model, SDB, closely interacting with obesity, was positively indirectly associated with hyperuricaemia through directly linked renal dysfunction and obesity-linked hypertension, inverse hyperglycaemia, dyslipidaemia, and hepatic dysfunction. In conclusion, structural equation modelling reveals that SDB closely interacts with obesity and is positively but indirectly related to hyperuricaemia in males. This suggests that urinary UA excretion modulates and obesity confounds the SDB-hyperuricaemia relationship.
C1 [Lai, Ching-Hsiang] Chung Shan Med Univ, Dept Med Informat, Taichung, Taiwan.
   [Huang, Ren-Jing] Chung Shan Med Univ, Dept Med Image & Radiol Sci, Taichung, Taiwan.
   [Wong, James Kok-Suh] Asia Univ Hosp, Dept Cardiol, Taichung, Taiwan.
   [Chang, Shen-Wen; Chung, Ai-Hui; Ting, Hua] Chung Shan Med Univ Hosp, Sleep Med Ctr, 110,Sec 1,Jianguo N Rd, Taichung 40201, Taiwan.
   [Chi, Yung-Chun; Yu, Yi-Chen; Ting, Hua] Chung Shan Med Univ Hosp, Dept Phys Med & Rehabil, Taichung, Taiwan.
   [Lee, Shin-Da] China Med Univ, Grad Inst Rehabil Sci, Dept Phys Therapy, Taichung, Taiwan.
   [Lee, Shin-Da] Asia Univ, Dept Occupat Therapy, Taichung, Taiwan.
   [Lee, Shin-Da] Shanghai Univ TCM, Sch Rehabil Sci, Affiliated People Hosp 7, Shanghai, Peoples R China.
   [Ting, Hua] Chung Shan Med Univ, Inst Med, Taichung, Taiwan.
C3 Chung Shan Medical University; Chung Shan Medical University; Chung Shan
   Medical University; Chung Shan Medical University Hospital; Chung Shan
   Medical University; Chung Shan Medical University Hospital; China
   Medical University Taiwan; Asia University Taiwan; Shanghai University
   of Traditional Chinese Medicine; Chung Shan Medical University
RP Ting, H (corresponding author), Chung Shan Med Univ Hosp, Sleep Med Ctr, 110,Sec 1,Jianguo N Rd, Taichung 40201, Taiwan.; Ting, H (corresponding author), Chung Shan Med Univ Hosp, Dept Phys Med & Rehabil, Taichung, Taiwan.; Ting, H (corresponding author), Chung Shan Med Univ, Inst Med, Taichung, Taiwan.
EM huating@csmu.edu.tw
RI Lee, Shin-Da/Q-2798-2015; Wang, Pa-Chun/AAD-4094-2019; Chuang,
   Hung-Yi/C-9143-2009
FU Shanghai Institute of Higher Education [2012-47]; Taiwan Ministry of
   Health and Welfare [MOHW106-TDU-B-212-113004]
FX Shanghai Institute of Higher Education, Grant/Award Number: 2012-47;
   Taiwan Ministry of Health and Welfare, Grant/Award Number:
   MOHW106-TDU-B-212-113004
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NR 38
TC 3
Z9 3
U1 1
U2 11
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0962-1105
EI 1365-2869
J9 J SLEEP RES
JI J. Sleep Res.
PD JUN
PY 2021
VL 30
IS 3
AR e13108
DI 10.1111/jsr.13108
EA AUG 2020
PG 11
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA SI6YK
UT WOS:000556232000001
PM 32767532
DA 2025-06-11
ER

PT J
AU Tomassoni, D
   Martinelli, I
   Moruzzi, M
   Di Bonaventura, MVM
   Cifani, C
   Amenta, F
   Tayebati, SK
AF Tomassoni, Daniele
   Martinelli, Ilenia
   Moruzzi, Michele
   Di Bonaventura, Maria Vittoria Micioni
   Cifani, Carlo
   Amenta, Francesco
   Tayebati, Seyed Khosrow
TI Obesity and Age-Related Changes in the Brain of the
   ZuckerLepr<SUP>fa/fa</SUP>Rats
SO NUTRIENTS
LA English
DT Article
DE brain alterations; diabetes; metabolic syndrome; neuromorphology;
   obesity; Zucker rats
ID BODY-MASS INDEX; METABOLIC SYNDROME; CARDIOVASCULAR-DISEASE; PROVISIONAL
   REPORT; OXIDATIVE STRESS; LIPID PEROXIDES; HEART-DISEASE; RATS;
   MICROGLIA; WEIGHT
AB Metabolic syndrome (MetS) is an association between obesity, dyslipidemia, hyperglycemia, hypertension, and insulin resistance. A relationship between MetS and vascular dementia was hypothesized. The purpose of this work is to investigate brain microanatomy alterations in obese Zucker rats (OZRs), as a model of MetS, compared to their counterparts lean Zucker rats (LZRs). 12-, 16-, and 20-weeks-old male OZRs and LZRs were studied. General physiological parameters and blood values were measured. Immunochemical and immunohistochemical techniques were applied to analyze the brain alterations. The morphology of nerve cells and axons, astrocytes and microglia were investigated. The blood-brain barrier (BBB) changes occurring in OZRs were assessed as well using aquaporin-4 (AQP4) and glucose transporter protein-1 (GLUT1) as markers. Body weight gain, hypertension, hyperglycemia, and hyperlipidemia were found in OZRs compared to LZRs. In the frontal cortex and hippocampus, a decrease of neurons was noticeable in the older obese rats in comparison to their age-matched lean counterparts. In OZRs, a reduction of neurofilament immunoreaction and gliosis was observed. The BBB of older OZRs revealed an increased expression of AQP4 likely related to the development of edema. A down-regulation of GLUT1 was found in OZRs of 12 weeks of age, whereas it increased in older OZRs. The behavioral analysis revealed cognitive alterations in 20-week-old OZRs. Based on these results, the OZRs may be useful for understanding the mechanisms through which obesity and related metabolic alterations induce neurodegeneration.
C1 [Tomassoni, Daniele] Univ Camerino, Sch Biosci & Vet Med, Via Gentile III Varano, I-62032 Camerino, Italy.
   [Martinelli, Ilenia; Di Bonaventura, Maria Vittoria Micioni; Cifani, Carlo; Amenta, Francesco; Tayebati, Seyed Khosrow] Univ Camerino, Sch Pharm, Via Madonna Carceri 9, I-62032 Camerino, Italy.
   [Moruzzi, Michele] Univ Leipzig, Dept Med, Liebigstr 21, D-04103 Leipzig, Germany.
C3 University of Camerino; University of Camerino; Leipzig University
RP Cifani, C; Tayebati, SK (corresponding author), Univ Camerino, Sch Pharm, Via Madonna Carceri 9, I-62032 Camerino, Italy.
EM daniele.tomassoni@unicam.it; ilenia.martinelli@unicam.it;
   michele.moruzzi@medizin.uni-leipzig.de; mariavittoria.micioni@unicam.it;
   carlo.cifani@unicam.it; francesco.amenta@unicam.it;
   khosrow.tayebati@unicam.it
RI Micioni Di Bonaventura, Maria Vittoria/AAC-5447-2022; Cifani,
   Carlo/AAC-5456-2022; Tayebati, Seyed/AGK-8739-2022
OI Micioni Di Bonaventura, Maria Vittoria/0000-0002-8044-1206; Francesco,
   Amenta/0000-0002-0555-1034; Cifani, Carlo/0000-0001-6180-828X;
   MARTINELLI, ILENIA/0000-0002-7702-7784; Tayebati, Seyed
   Khosrow/0000-0002-7219-6917; Tomassoni, Daniele/0000-0001-9062-3305
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NR 70
TC 28
Z9 29
U1 0
U2 2
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD MAY
PY 2020
VL 12
IS 5
AR 1356
DI 10.3390/nu12051356
PG 20
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA MB0AV
UT WOS:000542272700024
PM 32397542
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Mieno, Y
   Hayashi, M
   Sakakibara, H
   Takahashi, H
   Fujite, S
   Isogai, S
   Goto, Y
   Uozu, S
   Okazawa, M
   Imaizumi, K
AF Mieno, Yuki
   Hayashi, Masamichi
   Sakakibara, Hiroki
   Takahashi, Hiroshi
   Fujite, Shiho
   Isogai, Sumito
   Goto, Yasuhiro
   Uozu, Sakurako
   Okazawa, Mitsushi
   Imaizumi, Kazuyoshi
TI Gender Differences in the Clinical Features of Sleep Apnea Syndrome
SO INTERNAL MEDICINE
LA English
DT Article
DE sleep apnea; gender; polysomnography; metabolic syndrome
ID POSITIVE AIRWAY PRESSURE; METABOLIC SYNDROME; INSULIN-RESISTANCE;
   OXIDATIVE STRESS; GLUCOSE; POPULATION; PREVALENCE; COHORT; ADULTS; WOMEN
AB Objective Sleep apnea syndrome is more prevalent among men than women and is frequently accompanied by metabolic syndrome (MetS). However, gender differences in the effect of sleep-disordered breathing (SDB) leading to the risk of MetS remain unclear. The aim of our study was to investigate the clinical characteristics of SDB in women and the differential influence of SDB on MetS between genders.
   Methods In a single-center retrospective study, we compared the data of 1,809 consecutive SDB patients by gender to clarify the characteristics of sleep disorders in women. We also compared the prevalence of MetS and its related abnormalities by gender. A logistic regression analysis was used to determine the contributory factors for MetS.
   Results The mean age and proportion of patients over 50 years of age were higher in women than in men. SDB was milder in women than in men according to polysomnography findings. Elevated Hemoglobin A1c levels and hyperlipidemia were less frequent in women than in men. The MetS prevalence was similar in women and men (30.0% vs. 35.2%). A logistic regression analysis showed that the apnea-hypopnea index (AHI) was an independent risk factor for MetS in both genders, but that female gender was independently associated with a decreased prevalence of MetS and its related abnormalities.
   Conclusion Female SDB patients tend to be older with milder apnea and sleepiness than male SDB patients. A higher AHI is a significant risk factor for MetS in both genders, although female gender is an independent inhibitory factor for developing MetS in SDB patients.
C1 [Mieno, Yuki; Hayashi, Masamichi; Isogai, Sumito; Goto, Yasuhiro; Uozu, Sakurako; Imaizumi, Kazuyoshi] Fujita Hlth Univ, Dept Resp Med, Toyoake, Aichi, Japan.
   [Sakakibara, Hiroki] Tokushige Resp Clin, Nagoya, Aichi, Japan.
   [Takahashi, Hiroshi] Fujita Hlth Univ, Dept Med Stat, Toyoake, Aichi, Japan.
   [Fujite, Shiho] Fujita Hlth Univ, Dept Lab Med, Toyoake, Aichi, Japan.
   [Okazawa, Mitsushi] Daiyukai Hosp, Dept Resp Med, Ichinomiya, Japan.
C3 Fujita Health University; Fujita Health University; Fujita Health
   University
RP Mieno, Y (corresponding author), Fujita Hlth Univ, Dept Resp Med, Toyoake, Aichi, Japan.
EM mienon@fujita-hu.ac.jp
RI Hayashi, Masamichi/P-9743-2015
CR [Anonymous], 2005, INT CLASSIFICATION S, V2nd
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NR 30
TC 9
Z9 12
U1 0
U2 3
PU JAPAN SOC INTERNAL MEDICINE
PI TOKYO
PA 34-3 3-CHOME HONGO BUNKYO-KU, TOKYO, 113, JAPAN
SN 0918-2918
EI 1349-7235
J9 INTERNAL MED
JI Intern. Med.
PY 2018
VL 57
IS 15
BP 2157
EP 2163
DI 10.2169/internalmedicine.7570-16
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA GP3WB
UT WOS:000440784200008
PM 29607972
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Chen, Y
   Zhou, Z
   Li, XX
   Wang, T
AF Chen, Y.
   Zhou, Z.
   Li, X. -X.
   Wang, T.
TI Research on the protective effects of antioxidants on metabolic syndrome
   induced by thyroid dysfunction (Withdrawn Publication)
SO EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
LA English
DT Article; Withdrawn Publication
DE Impact factor; Metabolic syndrome; Thyroid abnormality; Numerical
   analysis algorithm
ID DENTAL PLAQUE; ASSOCIATION
AB OBJECTIVE: This paper researches on the protective effects of antioxidants on metabolic syndrome induced by thyroid dysfunction. While the role of Lipoic acid (LA), Resveratrol (R) and Quercetin (Q) are recognized, the mechanisms for their ameliorative effects are partially understood. Therefore, the objective of this study was to determine the prevalence of MS among university workers and to examine the relationship with thyroid function and mechanisms for protective effects of LA, Resveratrol and Quercetin on the heart, kidneys and lungs.
   SUBJECTS AND METHODS: In the cross-sectional study, a total of 2273 university workers (1198 males and 1075 females) aged 2260 participated. Anthropometric measurements (weight and height), blood pressure, fasting plasma glucose (FPG), lipids, liver and kidney function tests were carried out, thyroid stimulating hormone (TSH), free thyroxine (FT4), free triiodothyronine (FT3), total antioxidant capacity (T-AOC), lipid peroxidation products, malondialdehyde (MDA), advanced oxidation protein products (AOPP) and dityrosine levels were measured.
   RESULTS: A further evaluation of oxidative stress markers in subclinical hypothyroidism (SCH) compared with normal thyroid function showed the differences. Among middle-aged men with SCH (n = 467), MDA concentrations (8.11 +/- 1.39 nmol/ml) were significantly higher euthyroid controls (7.34 +/- 1.31 nmol/ml; n = 190) while AOPP, dityrosine and T-AOC levels were not different.
   CONCLUSIONS: It was demonstrated that prevalence of MS components was high. Targeting thyroid hormone restoration, inhibition of ACE and GSK3 via PI3K/AKT signaling path-way using LA, Resveratrol and Quercetin are potential novel therapeutic approaches for developing pharmaceuticals that could make significance in MS treatment.
C1 [Chen, Y.] Zhengzhou Univ, Affiliated Hosp 2, Dept Gerontol, Zhengzhou, Henan Province, Peoples R China.
   [Zhou, Z.] Zhengzhou Univ, Affiliated Hosp 2, Dept Resp Med, Zhengzhou, Henan Province, Peoples R China.
   [Li, X. -X.] Zhengzhou Univ, Affiliated Hosp 2, Dept Neurol, Zhengzhou, Henan Province, Peoples R China.
   [Wang, T.] Zhengzhou Univ, Affiliated Hosp 2, Dept Cardiol, Zhengzhou, Henan Province, Peoples R China.
C3 Zhengzhou University; Zhengzhou University; Zhengzhou University;
   Zhengzhou University
RP Wang, T (corresponding author), Zhengzhou Univ, Affiliated Hosp 2, Dept Cardiol, Zhengzhou, Henan Province, Peoples R China.
EM wangtao116848@163.com
RI WANG, Tiange/KEE-8267-2024
OI Wang, Tiange/0000-0003-0723-489X
FU Foundation of Henan Educational Committee [17A320009]
FX Foundation of Henan Educational Committee (Fund code: 17A320009.
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NR 16
TC 2
Z9 2
U1 0
U2 13
PU VERDUCI PUBLISHER
PI ROME
PA VIA GREGORIO VII, ROME, 186-00165, ITALY
SN 1128-3602
J9 EUR REV MED PHARMACO
JI Eur. Rev. Med. Pharmacol. Sci.
PD MAY
PY 2017
VL 21
IS 10
BP 2489
EP 2498
PG 10
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA EZ3ZP
UT WOS:000404650900027
PM 28617535
DA 2025-06-11
ER

PT J
AU Cardinali, DP
   Hardeland, R
AF Cardinali, Daniel P.
   Hardeland, Ruediger
TI Inflammaging, Metabolic Syndrome and Melatonin: A Call for Treatment
   Studies
SO NEUROENDOCRINOLOGY
LA English
DT Article
DE Melatonin; Metabolic syndrome; Inflammation; Diabetes; Obesity; Insulin
   signaling; Aging
ID HIGH-FAT DIET; ERYTHROID 2-RELATED FACTOR-2; HUMAN-PLATELET-AGGREGATION;
   INDUCED INSULIN-RESISTANCE; POLYCYSTIC-OVARY-SYNDROME; NOCTURNAL
   BLOOD-PRESSURE; TYPE-2 DIABETIC-PATIENTS; NUCLEAR FACTOR-KAPPAB;
   OXIDATIVE STRESS; WEIGHT-GAIN
AB The metabolic syndrome (MS) is a collection of risk factors for cardiovascular disease, including obesity, hypertension, hyperinsulinemia, glucose intolerance and dyslipidemia. MS is associated with low-grade inflammation of the white adipose tissue, which can subsequently lead to insulin resistance, impaired glucose tolerance and diabetes. Adipocytes secrete proinflammatory cytokines as well as leptin and trigger a vicious circle which leads to additional weight gain largely as fat. The imbalance between inflammatory and anti-inflammatory signals is crucial to aging. Healthy aging can benefit from melatonin, a compound known to possess direct and indirect antioxidant properties, to have a significant protective effect on mitochondrial function, to enhance circadian rhythm amplitudes, to modulate the immune system and to exhibit neuroprotective actions. Melatonin levels decrease in the course of senescence and are more strongly reduced in diseases related to insulin resistance. This short review article analyzes the multiple protective actions of melatonin that are relevant to the attenuation of inflammatory responses and progression of inflammaging and how melatonin is effective to curtail MS in animal models of hyperadiposity. The clinical data supporting the possible therapeutic use of melatonin in human MS are also reviewed. Since attention has been focused on the development of potent melatonin analogs with prolonged effects (ramelteon, agomelatine, tasimelteon, piromelatine) and in clinical trials these analogs were administered in doses considerably higher than those usually employed for melatonin, clinical trials on melatonin in the range of 50-100 mg/day are needed to further assess its therapeutic value in MS. (C) 2016 S. Karger AG, Basel
C1 [Cardinali, Daniel P.] Pontificia Univ Catolica Argentina, BIOMED UCA CONICET, Buenos Aires, DF, Argentina.
   [Cardinali, Daniel P.] Pontificia Univ Catol Argentina, Dept Teaching & Res, Fac Med Sci, Av Alicia Moreau de Justo 1500,4 Piso, RA-1107 Buenos Aires, DF, Argentina.
   [Hardeland, Ruediger] Univ Gottingen, Johann Friedrich Blumenbach Inst Zool & Anthropol, Gottingen, Germany.
C3 Pontificia Universidad Catolica Argentina; Pontificia Universidad
   Catolica Argentina; University of Gottingen
RP Cardinali, DP (corresponding author), Pontificia Univ Catol Argentina, Dept Teaching & Res, Fac Med Sci, Av Alicia Moreau de Justo 1500,4 Piso, RA-1107 Buenos Aires, DF, Argentina.
EM danielcardinali@uca.edu.ar
FU Agencia Nacional de Promocion Cientifica y Tecnologica, Argentina [2007
   01045, 2012 0984]
FX Studies conducted in Daniel P. Cardinali's laboratory were supported by
   grants PICT 2007 01045 and 2012 0984 from the Agencia Nacional de
   Promocion Cientifica y Tecnologica, Argentina.
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NR 148
TC 78
Z9 79
U1 0
U2 21
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0028-3835
EI 1423-0194
J9 NEUROENDOCRINOLOGY
JI Neuroendocrinology
PY 2017
VL 104
IS 4
BP 382
EP 397
DI 10.1159/000446543
PG 16
WC Endocrinology & Metabolism; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology
GA EQ8QU
UT WOS:000398351400006
PM 27165273
OA Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Méndez-Albiñana, P
   Rodrigues-Díez, R
   Rodríguez-Rodríguez, P
   Moreno, R
   Muñoz-Valverde, D
   Casani, L
   Villamiel, M
   Blanco-Rivero, J
AF Mendez-Albinana, Pablo
   Rodrigues-Diez, Raquel
   Rodriguez-Rodriguez, Pilar
   Moreno, Rodrigo
   Munoz-Valverde, David
   Casani, Laura
   Villamiel, Mar
   Blanco-Rivero, Javier
TI Structure and properties of citrus pectin as influencing factors of
   biomarkers of metabolic syndrome in rats fed with a high-fat diet
SO CURRENT RESEARCH IN FOOD SCIENCE
LA English
DT Article
DE Citrus pectin; Functional properties; Metabolic syndrome; Insulin
   resistance and hypertension
ID MESENTERIC-ARTERIES; OXIDATIVE STRESS; EXTRACTION; ACID
AB Pectin, widely used as a food and pharmaceutical ingredient, has garnered attention in recent years due to its bioactive properties. We conducted an in vivo study to evaluate the effects of citrus pectin on biomarkers of metabolic syndrome (MtS), including lipid profile, hypertension, and adipose tissue. Supplementing a high-fat diet (60% energy from fat) with 20% pectin for 4 weeks significantly reduced body weight and fat accumulation, improved insulin resistance, and decreased circulating leptin levels, demonstrating a beneficial effect on MtS. Pectin exhibited excellent viscosity, emulsifying properties, and water-holding capacity, forming a viscous gel in the gastrointestinal tract. This gel delays gastric emptying, enhances satiety, and reduces food and calorie intake, leading to lower weight gain in rats fed pectin. Its viscosity also interferes with lipase activity, lipid hydrolysis, and absorption, while its oil-holding capacity may help prevent lipid absorption. The presence of galactose in pectin's structure showed potential for improving insulin resistance. Furthermore, both degree of esterification (DE) and pH influence pectin's functionality. At acidic pH levels, such as those found in the stomach and duodenum, high methoxyl pectin (HMP) retains fats and bile salts more effectively, contributing to better cholesterol regulation. These effects, combined with the antioxidant properties of pectin, helped reverse arterial hypertension associated with MtS. Overall, our findings highlight the potential of citrus pectin as a natural bioactive ingredient for combating obesity-related disorders, complementing pharmacological treatments and promoting health through innovative dietary approaches.
C1 [Mendez-Albinana, Pablo; Rodriguez-Rodriguez, Pilar; Blanco-Rivero, Javier] Univ Autonoma Madrid, Sch Med, Dept Physiol, C Arzobispo Morcillo,4, Madrid 28029, Spain.
   [Mendez-Albinana, Pablo; Villamiel, Mar] UAM, Grp Chem & Funct Carbohydrates & Derivat, Food Sci Res Inst CIAL, CSIC, Madrid, Spain.
   [Rodrigues-Diez, Raquel] Univ Complutense Madrid, Sch Med, Dept Physiol, Madrid, Spain.
   [Rodrigues-Diez, Raquel; Rodriguez-Rodriguez, Pilar; Blanco-Rivero, Javier] Univ Hosp La Paz IdIPaz, Res Inst, Madrid, Spain.
   [Rodrigues-Diez, Raquel; Blanco-Rivero, Javier] Ctr Biomed Res Network CIBER Cardiovasc Dis, Madrid, Spain.
   [Moreno, Rodrigo] CSIC, Inst Ceram & Glass ICV, Madrid, Spain.
   [Munoz-Valverde, David] Univ Autonoma Madrid, Sch Med, Anim Headquarters, Madrid, Spain.
   [Casani, Laura] Santa Creu I St Pau Hosp, Res Inst, Barcelona, Spain.
C3 Autonomous University of Madrid; Autonomous University of Madrid;
   Consejo Superior de Investigaciones Cientificas (CSIC); Complutense
   University of Madrid; Consejo Superior de Investigaciones Cientificas
   (CSIC); CSIC - Instituto de Ceramica y Vidrio (ICV); Autonomous
   University of Madrid
RP Blanco-Rivero, J (corresponding author), Univ Autonoma Madrid, Sch Med, Dept Physiol, C Arzobispo Morcillo,4, Madrid 28029, Spain.; Villamiel, M (corresponding author), Food Sci Res Inst CIAL, Grp Chem & Funct Carbohydrates & Derivat, C Nicolas Cabrera 9, Madrid 28049, Spain.
EM m.villamiel@csic.es; javier.blanco@uam.es
RI Rivero, Javier/ABE-8749-2020; Rodríguez-Rodríguez, Pilar/Q-7664-2016;
   Díez, Raquel/ABE-9703-2020; Moreno, Rodrigo/L-3750-2017; Blanco Rivero,
   Javier/J-6118-2014
OI Moreno, Rodrigo/0000-0002-4826-5193; Mendez Albinana,
   Pablo/0009-0002-0988-2401; Rodrigues Diez, Raquel/0000-0002-6348-1505;
   Blanco Rivero, Javier/0000-0001-7232-2314
FU CiberCV; Ministerio de Ciencia e Innovacion [PID2021-123862OB-100,
   PID2022-138,610OB- 100]; CDTI-Center for Industrial Technological
   Development-project PID 2020-FEDER Funds; Luis Alvarez Fellowship
   (IdIPaz, 2023 Call);  [CB16/11/00286];  [PID2020-116498RB-100]
FX <STRONG> </STRONG>This research was funded by CiberCV (Grant number:
   CB16/11/00286) , and the Ministerio de Ciencia e Innovacion
   (PID2020-116498RB-100, PID2021-123862OB-100, PID2022-138,610OB- 100) ,
   CDTI-Center for Industrial Technological Development-project PID
   2020-FEDER Funds) , and Luis Alvarez Fellowship (IdIPaz, 2023 Call) .
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NR 57
TC 0
Z9 0
U1 6
U2 6
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
EI 2665-9271
J9 CURR RES FOOD SCI
JI Curr. Res. Food Sci.
PY 2025
VL 10
AR 101014
DI 10.1016/j.crfs.2025.101014
PG 10
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA Z6W2K
UT WOS:001440276100001
PM 40114745
OA gold
DA 2025-06-11
ER

PT J
AU Roudi, F
   Darroudi, S
   Saghi, E
   Hosseini, SR
   Kohantorabi, M
   Rezvani, A
   Jamialahmadi, T
   Sahebkar, A
   Moohebati, M
   Ghayour-Mobarhan, M
AF Roudi, Fatemeh
   Darroudi, Susan
   Saghi, Effat
   Hosseini, Seyed Reza
   Kohantorabi, Marzieh
   Rezvani, Alireza
   Jamialahmadi, Tannaz
   Sahebkar, Amirhossein
   Moohebati, Mohsen
   Ghayour-Mobarhan, Majid
TI The correlation between indirect calorimetry data and the metabolic
   syndrome development in men and women
SO JOURNAL OF DIABETES AND METABOLIC DISORDERS
LA English
DT Article
DE Metabolic syndrome; Indirect calorimetry; Resting metabolic rate;
   Macronutrient oxidation; Risk factors
ID ENERGY-EXPENDITURE; OXIDATIVE STRESS; TESTOSTERONE; PREVALENCE; OBESITY;
   FAT
AB ObjectivesTo investigate the indirect calorimetric findings in subjects with Metabolic Syndrome (MetS) compared to those without MetS and explore the potential parameters for predicting MetS in susceptible individuals.MethodsData was collected from a cross-sectional study conducted during the second phase of The Mashhad Stroke and Heart Atherosclerotic Disorder (MASHAD) study, which involved 1,014 participants. The presence of MetS was determined using the National Cholesterol Education Program Adult Treatment Panel III criteria. The study involved taking anthropometric measurements, blood samples, and indirect calorimetry measurements.ResultsThe study showed significant differences in MetS criteria between the groups with and without MetS. According to the results in men, an increase in resting metabolic rate (RMR)/weight decreased the likelihood of developing MetS. However, an increase in protein oxidation raised the probability of developing MetS. Moreover, an increased RMR/weight or RMR/ body surface area (BSA) decreased the likelihood of developing MetS in women. Based on the logistic regression analysis, men with a higher RMR/Weight had a lower risk of developing MetS. Conversely, an increase in protein oxidation can increase the risk of MetS. However, women with higher RMR/Weight and RMR/BSA had a reduced risk of developing MetS.ConclusionsThese findings suggest that variations in RMR and macronutrient oxidations may play a role in the development of MetS. Assessing RMR and macronutrient oxidation through indirect calorimetry could potentially be used as predictive parameters for MetS. Further research is needed to better understand the underlying mechanisms and implications of these findings.
C1 [Roudi, Fatemeh; Saghi, Effat] Mashhad Univ Med Sci, Fac Med, Dept Nutr, Mashhad, Iran.
   [Darroudi, Susan; Jamialahmadi, Tannaz; Ghayour-Mobarhan, Majid] Mashhad Univ Med Sci, Int UNESCO Ctr Hlth Related Basic Sci & Human Nutr, Mashhad, Iran.
   [Hosseini, Seyed Reza; Kohantorabi, Marzieh; Rezvani, Alireza] Mashhad Univ Med Sci, Metab Syndrome Res Ctr, Mashhad, Iran.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Appl Biomed Res Ctr, Mashhad, Iran.
   [Moohebati, Mohsen] Mashhad Univ Med Sci, Fac Med, Cardiovasc Res Ctr, Mashhad, Iran.
C3 Mashhad University of Medical Sciences; Mashhad University of Medical
   Sciences; Mashhad University of Medical Sciences; Mashhad University of
   Medical Sciences; Mashhad University of Medical Sciences
RP Ghayour-Mobarhan, M (corresponding author), Mashhad Univ Med Sci, Int UNESCO Ctr Hlth Related Basic Sci & Human Nutr, Mashhad, Iran.; Moohebati, M (corresponding author), Mashhad Univ Med Sci, Fac Med, Cardiovasc Res Ctr, Mashhad, Iran.
EM Mouhebatim@mums.ac.ir; ghayourm@mums.ac.ir
RI Sahebkar, Amirhossein/B-5124-2018; Ghayour-Mobarhan,
   Majid/AAY-5963-2020; Rezvani, Alireza/AAN-8058-2021; mohebati,
   mohsen/AAR-2016-2021
FU Mashhad University of Medical Sciences
FX We hereby express our gratitude to all the study participants, the local
   partners, and who helped us conduct this research.
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NR 37
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER INT PUBL AG
PI CHAM
PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND
EI 2251-6581
J9 J DIABETES METAB DIS
JI J. Diabetes Metab. Disord.
PD DEC 14
PY 2024
VL 24
IS 1
AR 1
DI 10.1007/s40200-024-01521-4
PG 6
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA P3W6O
UT WOS:001377256600001
PM 39686919
DA 2025-06-11
ER

PT J
AU Zhang, SY
   Xu, MY
   Shen, ZY
   Shang, CR
   Zhang, WX
   Chen, SY
   Liu, C
AF Zhang, Shiyao
   Xu, Mengyi
   Shen, Ziyue
   Shang, Changrui
   Zhang, Wenxiang
   Chen, Siyu
   Liu, Chang
TI Green light exposure aggravates high-fat diet feeding-induced hepatic
   steatosis and pancreatic dysfunction in male mice
SO ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
LA English
DT Article
DE Green light; Metabolic syndrome; Metabolite; Fatty liver; Hypoinsulinism
ID METABOLIC SYNDROME; OXIDATIVE STRESS; HIGH-SENSITIVITY; RECEPTORS;
   MELATONIN; OBESITY; NIGHT
AB The increased incidence of metabolic syndrome (MetS) has been demonstrated to be closely associated with external environments, such as unhealthy ambient light exposure. Of note, spectral distribution of the light functions as a critical determinant of light's pathophysiological effects. However, the effects of the lighting spectrum on metabolic homeostasis and the specific target organs remain elusive. To address this concern, we in this study high-fat diet (HFD)-fed obese mice with different spectra of the light, and divided them into white light (WL)-treated group, green light (GL)-treated group and blue light (BL)-treated group. We found that compared with BL-or WL-treated obese mice, animals exposed to GL showed worsened metabolic status, including increased body weight gain, impaired glucose tolerance/insulin sensitivity, increased levels of serum lipids, and decreased levels of serum insulin. At the organ level, GL exposure particularly exacerbated hepatic lipid accumulation and enlarged the islet volume. Taking advantages of metabolomics and transcriptomics analyses, we screened out taurocholic acid (TCA) and adenosine (AD) as two promising metabolites mediating the deleterious effects of GL on the liver and islets, respectively. In detail, GL aggravates HFD-induced lipid synthesis and gluconeogenesis in the liver via the reduction of TCA, while triggering inflammation and cellular dysfunction in islets via the induction of AD. Collectively, our findings confirmed that GL and the HFD have a synergistic effect in the induction of metabolic disorders. Data availability: All data supported the paper are present in the paper and/or the Supplementary Materials. The original datasets are also available from the corresponding author upon request.
C1 [Zhang, Shiyao; Xu, Mengyi; Shen, Ziyue; Shang, Changrui; Zhang, Wenxiang; Chen, Siyu; Liu, Chang] China Pharmaceut Univ, Sch Life Sci & Technol & Expt Platform Drug Chron, State Key Lab Nat Med, Nanjing, Jiangsu, Peoples R China.
   [Liu, Chang] Xinjiang Med Univ, Sch Pharm, Key Lab Act Components Nat Med & Drug Release Tec, Urumqi, Xinjiang, Peoples R China.
C3 China Pharmaceutical University; Xinjiang Medical University
RP Chen, SY; Liu, C (corresponding author), China Pharmaceut Univ, Sch Life Sci & Technol & Expt Platform Drug Chron, State Key Lab Nat Med, Nanjing, Jiangsu, Peoples R China.
EM siyuchen@cpu.edu.cn; changliu@cpu.edu.cn
RI Zhang, Shi-yao/GRO-1062-2022; Zhang, Wenxiang/HZK-0191-2023
OI Zhang, Shiyao/0000-0001-8871-0215
FU National Natural Science Foundation of China [92057112, 31771298,
   31800992, 81800512]; Natural Science Foundation of Jiangsu Province
   [BK20180554, BK20180577]; Project of State Key Laboratory of Natural
   Medicines, China Pharmaceutical University [SKLNMZZ202005]; Priority
   Academic Program Development of Jiangsu Higher Education Institutions
   (PAPD)
FX This work was financially supported by grants from the National Natural
   Science Foundation of China (92057112 and 31771298 to CL, 31800992 to
   SYC, 81800512 to WXZ), the Natural Science Foundation of Jiangsu
   Province (BK20180554 to SYC, BK20180577 to WXZ), the Project of State
   Key Laboratory of Natural Medicines, China Pharmaceutical University
   (SKLNMZZ202005 to CL), and the Priority Academic Program Development of
   Jiangsu Higher Education Institutions (PAPD, to CL and SYC).
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NR 44
TC 5
Z9 5
U1 2
U2 36
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0147-6513
EI 1090-2414
J9 ECOTOX ENVIRON SAFE
JI Ecotox. Environ. Safe.
PD DEC 1
PY 2021
VL 225
AR 112802
DI 10.1016/j.ecoenv.2021.112802
EA SEP 2021
PG 10
WC Environmental Sciences; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Toxicology
GA WC7EH
UT WOS:000704416800005
PM 34555719
OA gold
DA 2025-06-11
ER

PT J
AU Bacopoulou, F
   Landis, GN
   Palasz, A
   Tsitsika, A
   Vlachakis, D
   Tsarouhas, K
   Tsitsimpikou, C
   Stefanaki, C
   Kouretas, D
   Efthymiou, V
AF Bacopoulou, Flora
   Landis, Georgios N.
   Palasz, Artur
   Tsitsika, Artemis
   Vlachakis, Dimitrios
   Tsarouhas, Konstantinos
   Tsitsimpikou, Christina
   Stefanaki, Charikleia
   Kouretas, Dimitrios
   Efthymiou, Vasiliki
TI Identifying early abdominal obesity risk in adolescents by telemedicine:
   A cross-sectional study in Greece
SO FOOD AND CHEMICAL TOXICOLOGY
LA English
DT Article
DE School telemedicine; Abdominal obesity; Metabolic syndrome; Adolescents;
   Body composition; Waist circumference
ID BIOELECTRICAL-IMPEDANCE ANALYSIS; BODY-MASS INDEX; METABOLIC SYNDROME;
   OXIDATIVE STRESS; CHILDREN; ADIPOSITY; HEALTH; CHEMICALS; FAT;
   RELIABILITY
AB Obesity and thus, lipotoxicity, is a major health risk factor. Modern exposure to environmental chemicals has contributed significantly to the obesity epidemic. The purpose of this study was to assess, via telemedicine and using bioelectrical impedance analysis (BIA) in schools, the levels of adiposity and other body composition parameters of Greek adolescents in relation with their metabolic syndrome (MetS) characteristics.
   A representative sample (1575 adolescents, 14.4 +/- 1.7 years-old) of the Attica region population, underwent body composition assessment of fat mass (FM), fat-free mass (FFM), and total body water (TBW) and was evaluated for anthropometric and MetS characteristics.
   Males demonstrated higher FFM% and TBW% but lower FM% than females. Adolescents with abdominal obesity/MetS (n = 149/n = 40) demonstrated significantly (P < 0.001) higher body mass index (BMI 27.8 +/- 3.8 kg/m(2)/ 3 0.2 +/- 4.2 kg/m(2)) and FM (33.6 +/- 9.7%/35.0 +/- 10.5%) but significantly (P < 0.001) lower FFM (34.2 +/- 5.7%/33.8 +/- 6.2%) and TBW (45.6 +/- 6.7%/44.6 +/- 7.2%) than adolescents without abdominal obesity/MetS (BMI 20.9 +/- 2.8 kg/m(2)/ 21.3 +/- 3.2 kg/m(2); FM 19.2 +/- 6.9%/20.2 +/- 8.0%; FFM 41.3 +/- 4.4%/ 40.8 +/- 4.8%; TBW 55.5 +/- 4.8%/54.8 +/- 5.5%).
   Findings suggest that early "osteosarcopenic" elements of abdominal obesity/MetS may exist even in adolescence. The application of BIA, incorporated in the new approach methodology of telemedicine in schools, identified adolescents at risk for obesity complications.
C1 [Bacopoulou, Flora; Landis, Georgios N.; Stefanaki, Charikleia; Efthymiou, Vasiliki] Natl & Kapodistrian Univ Athens, Aghia Sophia Childrens Hosp, Ctr Adolescent Med, Sch Med, 1 Thivon St, Athens 11527, Greece.
   [Bacopoulou, Flora; Landis, Georgios N.; Stefanaki, Charikleia; Efthymiou, Vasiliki] Natl & Kapodistrian Univ Athens, Aghia Sophia Childrens Hosp, UNESCO Chair Adolescent Hlth Care, Dept Pediat 1,Sch Med, 1 Thivon St, Athens 11527, Greece.
   [Palasz, Artur] Med Univ Silesia, Sch Med Katowice, Dept Histol, Ul Medykow 18, PL-40752 Katowice, Poland.
   [Tsitsika, Artemis] Natl & Kapodistrian Univ Athens, P&A Kyriakou Childrens Hosp, Sch Med, Dept Pediat 2,Adolescent Hlth Unit, Thivon & Levadeias St, Athens 11527, Greece.
   [Vlachakis, Dimitrios] Agr Univ Athens, Sch Food Biotechnol & Dev, Dept Biotechnol, Lab Genet, Athens, Greece.
   [Vlachakis, Dimitrios] Kings Coll London, Fac Nat & Math Sci, Dept Informat, London, England.
   [Tsarouhas, Konstantinos] Univ Hosp Larissa, Dept Cardiol, Larisa, Greece.
   [Tsitsimpikou, Christina] Gen Chem State Lab Greece, 16 An Tsocha St, Athens 11521, Greece.
   [Kouretas, Dimitrios] Univ Thessaly, Dept Biochem & Biotechnol, Larisa, Greece.
C3 Athens Medical School; National & Kapodistrian University of Athens; The
   Aghia Sophia Children's Hospital; National & Kapodistrian University of
   Athens; Athens Medical School; The Aghia Sophia Children's Hospital;
   Medical University of Silesia; Athens Medical School; National &
   Kapodistrian University of Athens; Agricultural University of Athens;
   University of London; King's College London; General University Hospital
   of Larissa; University of Thessaly
RP Bacopoulou, F (corresponding author), Natl & Kapodistrian Univ Athens, Sch Med, Ctr Adolescent Med, 1 Thivon St, Athens 11527, Greece.; Bacopoulou, F (corresponding author), Natl & Kapodistrian Univ Athens, Sch Med, UNESCO Chair Adolescent Hlth Care, Dept Pediat 1, 1 Thivon St, Athens 11527, Greece.; Bacopoulou, F (corresponding author), Aghia Sophia Childrens Hosp, Ctr Adolescent Med, 1 Thivon St, Athens 11527, Greece.
EM fbacopoulou@med.uoa.gr; georgioslandis@yahoo.co.uk; apalasz@sum.edu.pl;
   atsitsik@med.uoa.gr; dimvl@aua.gr; ktsarouhas14@yahoo.gr;
   chtsitsi@yahoo.com; cstefanaki@gmail.com; dkouret@uth.gr;
   vikimiou2003@yahoo.gr
RI KOURETAS, DEMETRIOS/ABE-8519-2020; Bacopoulou, Flora/AAH-1218-2019;
   Stefanaki, Charikleia/G-6653-2012; Efthymiou, Vasiliki/GWC-7978-2022;
   Vlachakis, Dimitrios/O-4323-2018; Tsarouhas, Konstantinos/H-5793-2019
OI Vlachakis, Dimitrios/0000-0003-1823-6102; Stefanaki,
   Charikleia/0000-0003-1634-701X; Tsarouhas,
   Konstantinos/0000-0003-2651-3579
FU European Union [MIS 371406]
FX The program was funded by the European Union in the context of the
   National Strategic Reference Framework 2007-2013 (program code MIS
   371406). The funding source had no involvement in the study design; in
   the collection, analysis, and interpretation of data; in the writing of
   the manuscript; and in the decision to submit the paper for publication.
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NR 66
TC 7
Z9 7
U1 0
U2 5
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0278-6915
EI 1873-6351
J9 FOOD CHEM TOXICOL
JI Food Chem. Toxicol.
PD OCT
PY 2020
VL 144
AR 111532
DI 10.1016/j.fct.2020.111532
PG 8
WC Food Science & Technology; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Toxicology
GA NK6AX
UT WOS:000566815000002
PM 32645466
DA 2025-06-11
ER

PT J
AU Poniedzialek-Czajkowska, E
   Mierzynski, R
   Kimber-Trojnar, Z
   Leszczynska-Gorzelak, B
   Oleszczuk, J
AF Poniedzialek-Czajkowska, Elzbieta
   Mierzynski, Radzislaw
   Kimber-Trojnar, Zaneta
   Leszczynska-Gorzelak, Bozena
   Oleszczuk, Jan
TI Polyunsaturated Fatty Acids in Pregnancy and Metabolic Syndrome: A
   Review
SO CURRENT PHARMACEUTICAL BIOTECHNOLOGY
LA English
DT Review
DE DHA; EPA; gestational diabetes mellitus; metabolic syndrome;
   polyunsaturated fatty acids; pregnancy; preeclampsia
ID FISH-OIL SUPPLEMENTATION; NF-KAPPA-B; ACTIVATED PROTEIN-KINASE;
   ALPHA-LINOLENIC ACID; BODY-MASS INDEX; INSULIN-RESISTANCE;
   EICOSAPENTAENOIC ACID; DOCOSAHEXAENOIC ACID; MATERNAL OBESITY; OXIDATIVE
   STRESS
AB This review presents available evidence for possible application of n-3 long chain polyunsaturated fatty acids (PUFAs) in pregnant obese women with metabolic syndrome (MS) and focuses on prophylaxis of pregnancy complications associated with MS such as gestational hypertension, preeclampsia and gestational diabetes. Dietary supplementation with n-3 PUFAs has recently become popular and their adequate intake during pregnancy and early childhood is of clinical importance. The results of experimental and epidemiological investigations reveal that n-3 PUFAs, especially alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA), may decrease the risk of cardiovascular diseases. It is believed that n-3 PUFAs affect a multitude of molecular pathways, involving regulation of gene expression, alteration of physical and chemical properties of cellular membranes and modulation of membrane channels and proteins. A large body of evidence focuses on anti-inflammatory properties of PUFAs which seem to be fundamental in prevention and reversing of insulin resistance, atherogenic dyslipidemia, hypertension, thromboembolism and in improving vascular function. Despite the potential PUFAs benefits of decreasing insulin resistance, their application in order to prevent preeclampsia, gestational hypertension and gestational diabetes mellitus in pregnant women with MS has not yet been established. Numerous reports have revealed that appropriate fetal development, including neuronal, retinal and immune function depends on EPA and DHA which are crucial also for prevention of preterm birth. Thus the supplementation with EPA and DHA is highly recommended during pregnancy although the optimal dosing and treatment strategies still need to be determined.
C1 [Poniedzialek-Czajkowska, Elzbieta; Mierzynski, Radzislaw; Kimber-Trojnar, Zaneta; Leszczynska-Gorzelak, Bozena; Oleszczuk, Jan] Med Univ Lublin, Dept Obstet & Perinatol, PL-20954 Lublin, Poland.
C3 Medical University of Lublin
RP Poniedzialek-Czajkowska, E (corresponding author), Med Univ Lublin, Dept Obstet & Perinatol, Ul Jaczewskiego 8, PL-20954 Lublin, Poland.
EM elzbietapc@yahoo.com
OI Kimber-Trojnar, Zaneta/0000-0001-7295-0409
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NR 195
TC 6
Z9 7
U1 0
U2 35
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1389-2010
EI 1873-4316
J9 CURR PHARM BIOTECHNO
JI Curr. Pharm. Biotechnol.
PY 2014
VL 15
IS 1
BP 84
EP 99
DI 10.2174/1389201015666140330195614
PG 16
WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
GA AL1YD
UT WOS:000338921600010
PM 24720591
DA 2025-06-11
ER

PT J
AU Rider, P
   Voronov, E
   Dinarello, CA
   Apte, RN
   Cohen, I
AF Rider, Peleg
   Voronov, Elena
   Dinarello, Charles A.
   Apte, Ron N.
   Cohen, Idan
TI Alarmins: Feel the Stress
SO JOURNAL OF IMMUNOLOGY
LA English
DT Review
ID GROUP BOX 1; CHROMATIN PROTEIN HMGB1; N-TERMINAL PROPIECE; STERILE
   INFLAMMATION; POSTTRANSLATIONAL MODIFICATIONS; DNA-DAMAGE;
   SUBCELLULAR-LOCALIZATION; NUCLEAR TRANSLOCATION; METABOLIC SYNDROME;
   OXIDATIVE STRESS
AB Over the last decade, danger-associated molecular pattern molecules, or alarmins, have been recognized as signaling mediators of sterile inflammatory responses after trauma and injury. In contrast with the accepted passive release models suggested by the "danger hypothesis," it was recently shown that alarmins can also directly sense and report damage by signaling to the environment when released from live cells undergoing physiological stress, even without loss of subcellular compartmentalization. In this article, we review the involvement of alarmins such as IL-1 alpha, IL-33, IL-16, and high-mobility group box 1 in cellular and physiological stress, and suggest a novel activity of these molecules as central initiators of sterile inflammation in response to nonlethal stress, a function we denote "stressorins." We highlight the role of posttranslational modifications of stressorins as key regulators of their activity and propose that targeted inhibition of stressorins or their modifiers could serve as attractive new anti-inflammatory treatments for a broad range of diseases.
C1 [Rider, Peleg] Ben Gurion Univ Negev, Dept Clin Biochem & Pharmacol, IL-84105 Beer Sheva, Israel.
   [Voronov, Elena; Apte, Ron N.] Ben Gurion Univ Negev, Shraga Segal Dept Microbiol Immunol & Genet, IL-84105 Beer Sheva, Israel.
   [Dinarello, Charles A.] Univ Colorado Denver, Aurora, CO 80045 USA.
   [Cohen, Idan] Nahariya Hosp, Fac Med, Galilee Med Ctr, IL-22100 Nahariyya, Israel.
C3 Ben-Gurion University of the Negev; Ben-Gurion University of the Negev;
   Children's Hospital Colorado; University of Colorado System; University
   of Colorado Anschutz Medical Campus; Western Galilee Hospital
RP Cohen, I (corresponding author), Nahariya Hosp, Galilee Med Ctr, IL-22100 Nahariyya, Israel.
EM IdanC@gmc.gov.il
RI Dinarello, Charles/C-8524-2013; Cohen‬‏, ‪Idan/AAD-6997-2021
OI Cohen, Idan/0000-0001-6933-9385
FU Ministry of Aliya and Immigrant Asorption; Center for Absorption in
   Science, Israel; Israel Ministry of Science; Deutsches
   Krebsforschungscentrum, Heidelberg, Germany; Israel Science Foundation -
   Israel Academy of Sciences and Humanities; Israel Cancer Association;
   Israel Ministry of Health Chief Scientist's Office, 7th Framework
   Programme for Research and Technological Development: Cancer
   Inflammation (INFLA-CARE); Binational (Israel) Science Foundation;
   German-Israeli Foundation
FX This work was supported by the Ministry of Aliya and Immigrant Asorption
   (I.C.); the Center for Absorption in Science, Israel (I.C.); the Israel
   Ministry of Science jointly with the Deutsches Krebsforschungscentrum,
   Heidelberg, Germany (R.N.A. and E.V.); the Israel Science Foundation
   supported by the Israel Academy of Sciences and Humanities (R.N.A. and
   E.V.); the Israel Cancer Association and the Israel Ministry of Health
   Chief Scientist's Office, 7th Framework Programme for Research and
   Technological Development: Cancer Inflammation (INFLA-CARE) (R.N.A. and
   E.V.); the Binational (Israel) Science Foundation (R.N.A. and E.V.); and
   the German-Israeli Foundation (R.N.A. and E.V.).
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NR 114
TC 143
Z9 158
U1 0
U2 18
PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-1767
EI 1550-6606
J9 J IMMUNOL
JI J. Immunol.
PD FEB 15
PY 2017
VL 198
IS 4
BP 1395
EP 1402
DI 10.4049/jimmunol.1601342
PG 8
WC Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology
GA EN3HC
UT WOS:000395898600003
PM 28167650
DA 2025-06-11
ER

PT J
AU Nina, N
   Theoduloz, C
   Tapia, G
   Jimenéz-Aspee, F
   Márquez, K
   Schmeda-Hirschmann, G
AF Nina, Nelida
   Theoduloz, Cristina
   Tapia, Gerardo
   Jimenez-Aspee, Felipe
   Marquez, Katherine
   Schmeda-Hirschmann, Guillermo
TI Changes in polyphenol composition, antioxidant capacity and enzyme
   inhibition in Phaseolus vulgaris L. submitted to hydric stress
SO SCIENTIA HORTICULTURAE
LA English
DT Article
DE Water stress; Latin American beans; Phenolics; Enzyme inhibition;
   alpha-glucosidase; alpha-amylase; Phaseolus vulgaris
ID CURRANTS RIBES SPP.; DROUGHT STRESS; COMMON; BEANS; PHENOLICS; ASSAY
AB The beans (Phaseolus vulgaris L.) are native American legumes with high nutritional value and health benefits. The aim of this study was to assess the impact of hydric stress on the phenolic composition, antioxidant capacity, and inhibition of enzymes associated with metabolic syndrome, in nine bean landraces cultivated in the Mediterranean zone of Chile. The polyphenolic enriched extract (PEE) from the seeds were analyzed for total phenolic, flavonoid, proanthocyanidin content, and antioxidant capacity. The main compounds were quantified by HPLC. The activity of the extracts on the enzymes alpha-glucosidase, alpha-amylase, and pancreatic lipase was assessed. Under restricted watering, all phenolic compounds increased in Pinto beans and decreased in other accessions. Best effect towards alpha-glucosidase was observed for Negro Argel, Bayote, and Enriqueta with IC50 between 0.006 mu g/mL and 0.820 mu g/mL. Water stress has a significant effect on polyphenols composition and consequently on the antioxidant activity and inhibition of enzymes.
C1 [Nina, Nelida; Schmeda-Hirschmann, Guillermo] Univ Talca, Lab Quim Prod Nat, Inst Quim Recursos Nat, Campus Lircay, Talca 3480094, Chile.
   [Theoduloz, Cristina] Univ Talca, Fac Ciencias Salud, Lab Cult Celular, Campus Lircay, Talca 3480094, Chile.
   [Tapia, Gerardo] Inst Invest Agr, INIA Quilamapu, Unidad Recursos Genet Vegetales, Chillan 3800062, Chile.
   [Jimenez-Aspee, Felipe] Univ Hohenheim, Inst Nutr Sci, Dept Food Biofunct 140b, D-70599 Stuttgart, Germany.
   [Theoduloz, Cristina; Tapia, Gerardo; Marquez, Katherine; Schmeda-Hirschmann, Guillermo] Ctr Estudios Alimentos Proc CEAP, Campus Lircay, Talca 3480094, Chile.
   [Schmeda-Hirschmann, Guillermo] Univ Talca, Inst Quim Recursos Nat, Lab Quim Prod Nat, Talca 3480094, Chile.
C3 Universidad de Talca; Universidad de Talca; University Hohenheim;
   Universidad de Talca
RP Schmeda-Hirschmann, G (corresponding author), Univ Talca, Inst Quim Recursos Nat, Lab Quim Prod Nat, Talca 3480094, Chile.
EM schmeda@utalca.cl
RI Márquez, Katherine/JDM-7512-2023; Aspee, Felipe/ABA-2948-2020; Jimenez
   Aspee, Felipe/G-6955-2017; Schmeda Hirschmann, Guillermo/G-1046-2010
OI Jimenez Aspee, Felipe/0000-0002-7285-7033; Marquez,
   Katherine/0000-0001-6298-2597; Schmeda Hirschmann,
   Guillermo/0000-0002-9228-5378
FU FONDECYT [1210076]; Proyecto Fortalecimiento al Desarrollo Cientifico de
   Centros Regionales-ANID; ANID;  [R20F0001CEAP];  [21192237]
FX This research received funding from FONDECYT 1210076 and Proyecto
   Fortalecimiento al Desarrollo Cientifico de Centros Regionales-ANID
   R20F0001CEAP. N.N. thanks ANID for a doctoral grant Folio 21192237. We
   are grateful to Dr. J. Alarc'on-Esp'osito for her technical help.
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NR 47
TC 11
Z9 11
U1 4
U2 19
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0304-4238
EI 1879-1018
J9 SCI HORTIC-AMSTERDAM
JI Sci. Hortic.
PD JUL 1
PY 2023
VL 317
AR 112070
DI 10.1016/j.scienta.2023.112070
EA APR 2023
PG 10
WC Horticulture
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture
GA G0YH0
UT WOS:000986510400001
DA 2025-06-11
ER

PT S
AU Vrekoussis, T
   Kalantaridou, SN
   Mastorakos, G
   Zoumakis, E
   Makrigiannakis, A
   Syrrou, M
   Lavasidis, LG
   Relakis, K
   Chrousos, GP
AF Vrekoussis, Thomas
   Kalantaridou, Sophia N.
   Mastorakos, George
   Zoumakis, Emmanuel
   Makrigiannakis, Antonis
   Syrrou, Marika
   Lavasidis, Lazaros G.
   Relakis, Kostas
   Chrousos, George P.
BE Creatsas, G
   Mastorakos, G
TI The role of stress in female reproduction and pregnancy: an update
SO WOMEN'S HEALTH AND DISEASE
SE Annals of the New York Academy of Sciences
LA English
DT Article; Proceedings Paper
CT 7th Athens Conference on Women's Health and Disease: Gynecologic,
   Endocrine, and Reproductive Issues
CY SEP 11-13, 2008
CL Athens, GREECE
DE fetal programming; female reproduction; parturition; pregnancy; stress
ID CORTICOTROPIN-RELEASING HORMONE; FETAL-GROWTH RESTRICTION;
   HUMAN-PLACENTA; PRETERM BIRTH; BINDING PROTEIN; PRENATAL STRESS;
   PREECLAMPSIA; PLASMA; AXIS; CRH
AB Life exists by establishing a balanced equilibrium, called homeostasis, constantly challenged by adverse stimuli, called stressors. In response to these stimuli, a complex neurohormonal reaction exerted by the activation of the so-called stress system is initiated. The latter is activated in a coordinated fashion, leading to behavioral and peripheral changes that improve the ability of the organism to adjust homeostasis and increase its chance for survival. The stress system suppressive effects on female reproduction involve suppression of the hypothalamic pituitary ovarian axis at the hypothalamic, pituitary, ovarian, and uterine levels. Experimental and human data suggest that adverse prenatal stimuli, of either maternal or fetal origin, acting in the developing embryo in utero, can lead to the development of short-and long-term health disorders. These include preterm birth of the offspring, low birth weight, and the development of adult diseases ranging from the metabolic syndrome to several neurodevelopmental disorders.
C1 [Vrekoussis, Thomas; Kalantaridou, Sophia N.; Lavasidis, Lazaros G.] Univ Ioannina, Sch Med, Dept Obstet & Gynecol, GR-45110 Ioannina, Greece.
   [Mastorakos, George] Univ Athens, Sch Med, Aretaie Hosp, Dept Obstet & Gynecol 2, GR-11527 Athens, Greece.
   [Zoumakis, Emmanuel; Chrousos, George P.] Univ Athens, Dept Pediat 1, Choreme Res Lab, Athens, Greece.
   [Makrigiannakis, Antonis; Relakis, Kostas] Univ Crete, Sch Med, Dept Obstet & Gynecol, Iraklion, Greece.
   [Syrrou, Marika] Univ Ioannina, Sch Med, Dept Gen Biol, Genet Unit, GR-45110 Ioannina, Greece.
C3 University of Ioannina; National & Kapodistrian University of Athens;
   Athens Medical School; National & Kapodistrian University of Athens;
   University of Crete; University of Ioannina
RP Vrekoussis, T (corresponding author), Univ Ioannina, Sch Med, Dept Obstet & Gynecol, GR-45110 Ioannina, Greece.
EM tvrek@med.uoc.gr
RI Chrousos, George/G-8702-2011
OI Makrigiannakis, Antonis/0000-0002-8475-1500; Kalantaridou,
   Sophia/0000-0002-0590-1575; SYRROU, MARIA/0000-0002-5748-5008
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NR 40
TC 45
Z9 52
U1 2
U2 19
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN STREET, MALDEN 02148, MA USA
SN 0077-8923
BN 978-1-57331-768-9
J9 ANN NY ACAD SCI
JI Ann.NY Acad.Sci.
PY 2010
VL 1205
BP 69
EP 75
DI 10.1111/j.1749-6632.2010.05686.x
PG 7
WC Endocrinology & Metabolism; Multidisciplinary Sciences; Obstetrics &
   Gynecology; Reproductive Biology
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Science & Technology - Other Topics;
   Obstetrics & Gynecology; Reproductive Biology
GA BRM37
UT WOS:000283095800011
PM 20840255
DA 2025-06-11
ER

PT J
AU Almenara, CCP
   Mill, JG
   Vassallo, DV
   Bald, MP
   Padilha, AS
AF Almenara, Camila C. P.
   Mill, Jose G.
   Vassallo, Dalton V.
   Bald, Marcelo P.
   Padilha, Alessandra S.
TI In vitro fructose exposure overactivates NADPH oxidase and causes
   oxidative stress in the isolated rat aorta
SO TOXICOLOGY IN VITRO
LA English
DT Article
DE Fructose; Oxidative stress; NADPH oxidase; Endothelial dysfunction
ID INDUCED METABOLIC SYNDROME; INSULIN-RESISTANCE; NITRIC-OXIDE; VASCULAR
   DYSFUNCTION; EXPERIMENTAL-MODEL; CORN SYRUP; HYPERTENSION; SUCROSE;
   ATORVASTATIN; RELAXATION
AB Fructose acutely interferes with cardiovascular function in humans and in animals, but the mechanisms remain unclear. Thus, we tested whether fructose can affect endothelial function without the interference of its metabolic effect by exposing the rat aorta to a high fructose concentration and then evaluate the vascular responses to vasoactive agents. We observed that fructose exposure causes overactivation of NADPH oxidase, which enhances superoxide anion production and increases NO degradation. Additionally, the enhanced vasoconstrictor action of hydrogen peroxide might exacerbate contractile responses. This vasoactive imbalance might be the key role by which fructose induces vascular dysfunction. (C) 2015 Elsevier Ltd. All rights reserved.
C1 [Almenara, Camila C. P.; Mill, Jose G.; Vassallo, Dalton V.; Bald, Marcelo P.; Padilha, Alessandra S.] Univ Fed Espirito Santo, Dept Physiol Sci, Vitoria, ES, Brazil.
   [Mill, Jose G.] Univ Fed Espirito Santo, Post Grad Program Collect Hlth, BR-29042755 Vitoria, ES, Brazil.
C3 Universidade Federal do Espirito Santo; Universidade Federal do Espirito
   Santo
RP Padilha, AS (corresponding author), Univ Fed Espirito Santo, Ctr Ciencias Saude, Dept Ciencias Fisiol, Ave Marechal Campos 1468, BR-29040091 Vitoria, ES, Brazil.
EM ale_padilha@hotmail.com
RI Baldo, Marcelo/G-6994-2012; Vassallo, Dalton/K-8289-2016
OI Vassallo, Dalton/0000-0002-4463-4174; Baldo, Marcelo/0000-0002-7673-3580
FU Conselho Nacional de Desenvolvimento Cientifico e Tecnologico - CNPq
   [470748/2013-3, 400484/2013-7]; CAPES (Coordenacao de Aperfeicoamento de
   Pessoal de Nivel Superior)
FX This work was supported by grants from the Conselho Nacional de
   Desenvolvimento Cientifico e Tecnologico - CNPq [470748/2013-3;
   400484/2013-7] and CAPES (Coordenacao de Aperfeicoamento de Pessoal de
   Nivel Superior). The funders had no role in the study design, data
   collection and analysis, decision to publish or preparation of the
   manuscript. The authors declare that they have no conflicts of interest.
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NR 45
TC 12
Z9 12
U1 0
U2 6
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0887-2333
EI 1879-3177
J9 TOXICOL IN VITRO
JI Toxicol. Vitro
PD DEC
PY 2015
VL 29
IS 8
BP 2030
EP 2037
DI 10.1016/j.tiv.2015.08.013
PG 8
WC Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Toxicology
GA CW3KU
UT WOS:000364892000009
PM 26320835
DA 2025-06-11
ER

PT J
AU Petrova, J
   Cherneva, R
   Georgiev, O
   Petrova, D
   Valev, D
AF Petrova, Julia
   Cherneva, Radostina
   Georgiev, Ognian
   Petrova, Daniela
   Valev, Dinko
TI THE ROLE OF OXIDATIVE STRESS IN ENDOTHELIAL DYSFUNCTION IN OSA PATIENTS
SO COMPTES RENDUS DE L ACADEMIE BULGARE DES SCIENCES
LA English
DT Article
DE endothelial dysfunction; flow mediated brachial artery dilation (FMD);
   oxidative stress; OSA
ID OBSTRUCTIVE SLEEP-APNEA; LIPID-PEROXIDATION; NITRIC-OXIDE; FLOW;
   VASODILATION; MARKERS
AB Endothelial dysfunction is highly prevalent among OSA patients. However, its pathogenetic mechanisms are not thoroughly studied. The aim of our study was to evaluate the role of oxidative stress in the pathogenesis of endothelial dysfunction among OSA patients and to compare it to healthy control subjects. We studied 98 consecutive patients, who were referred to the clinic for probable OSA. Patients underwent standard polysomnography. To assess oxidative stress, we measured urinary 8-iso-PGF2 alpha. Flow mediated brachial artery dilation (FMD) was determined to assess endothelial function. Patients with moderate-severe OSAS had higher urinary 8-iso-PGF2 alpha (0.021 pg/mu mo1/1 cre), compared to healthy subjects (0.017 pg/mu mo1/1 cre, p = 0.037). In contrast to metabolic syndrome urinary 8-isoprostanes were the only independent predictors of FMD (beta = -0.21, p < 0.048). In conclusion, the results of our study indicate that patients with OSAS have an increased oxidative stress, that is implicated in the pathogenesis of arterial dysfunction.
C1 [Petrova, Julia; Cherneva, Radostina] Med Univ Sofia, Dept Neurol, Sofia, Bulgaria.
   [Georgiev, Ognian; Petrova, Daniela; Valev, Dinko] Med Univ Sofia, Div Pulm Med, Sofia 1431, Bulgaria.
C3 Medical University Sofia; Medical University Sofia
RP Petrova, J (corresponding author), Med Univ Sofia, Dept Neurol, Sofia, Bulgaria.
EM cherneva_radost@yahoo.com
RI Petrova, Daniela/GXA-2866-2022; Valev, Dimitar/E-6179-2011
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NR 20
TC 0
Z9 0
U1 1
U2 3
PU PUBL HOUSE BULGARIAN ACAD SCI
PI SOFIA
PA ACADEMICIAN G BONCEV ST, 1113 SOFIA, BULGARIA
SN 1310-1331
J9 CR ACAD BULG SCI
JI C. R. Acad. Bulg. Sci.
PY 2015
VL 68
IS 11
BP 1457
EP 1462
PG 6
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA DA2OB
UT WOS:000367634600016
DA 2025-06-11
ER

PT J
AU Charradi, K
   Elkahoui, S
   Karkouch, I
   Limam, F
   Hamdaoui, G
   Ben Hassine, F
   El May, MV
   El May, A
   Aouani, E
AF Charradi, Kamel
   Elkahoui, Salem
   Karkouch, Ines
   Limam, Ferid
   Hamdaoui, Ghaith
   Ben Hassine, Fethy
   El May, Michele Veronique
   El May, Ahmed
   Aouani, Ezzedine
TI Grape seed and skin extract alleviates high-fat diet-induced renal
   lipotoxicity and prevents copper depletion in rat
SO APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
LA English
DT Article
DE copper; grape polyphenols; kidney; obesity; oxidative stress
ID CHRONIC KIDNEY-DISEASE; METABOLIC SYNDROME; OXIDATIVE STRESS; OBESITY;
   BIOAVAILABILITY; APOPTOSIS; SERUM; ACID; ZINC
AB Obesity is a public health problem that contributes to morbidity and mortality from diabetes, heart disease, stroke, and cancers. The purpose of this investigation was to analyse the link between obesity-induced oxidative stress, renal steatosis, and kidney dysfunction, as well as the protective effect of grape seed and skin extract. Rats were fed a standard diet or a high-fat diet for 6 weeks and were either treated or not treated with grape seed and skin extract. Fat-induced oxidative stress was evaluated in the kidney with a special emphasis on transition metals. High-fat diet induced triglyceride deposition and disturbances in kidney function parameters, which are linked to an oxidative stress status and depletion of copper from the kidney. Grape seed and skin extract abrogated almost all fat-induced kidney disturbances. Grape seed and skin extract exerted potential protection against fat-induced kidney lipotoxicity and should find potential application in other kidney-related diseases.
C1 [Charradi, Kamel; Elkahoui, Salem; Karkouch, Ines; Limam, Ferid; Hamdaoui, Ghaith; Aouani, Ezzedine] Ctr Biotechnol Borj Cedria, Lab Subst Bioact LSBA, Hammam Lif 2050, Tunisia.
   [Charradi, Kamel; Aouani, Ezzedine] Univ Carthage, Fac Sci Bizerte, Jarzouna 7021, Tunisia.
   [Ben Hassine, Fethy] CNSS El Khadra, Polyclin, Biochim Lab, Cite El Khadra Tunis 1003, Tunisia.
   [El May, Michele Veronique; El May, Ahmed] Fac Med Tunis, Unite Rech UR 07 08 01, Tunis, Tunisia.
C3 Centre de Biotechnologie de Borj Cedria; Universite de Carthage;
   Universite de Tunis-El-Manar; Faculte de Medecine de Tunis (FMT)
RP Charradi, K (corresponding author), Ctr Biotechnol Borj Cedria, Lab Subst Bioact LSBA, BP 901, Hammam Lif 2050, Tunisia.
EM charradi3@yahoo.com
RI Charradi, Kamel/AAR-8778-2021; ELKAHOUI, Salem/AAR-6542-2021
OI ELKAHOUI, SALEM/0000-0001-5577-1011
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NR 47
TC 22
Z9 27
U1 0
U2 22
PU CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS
PI OTTAWA
PA 65 AURIGA DR, SUITE 203, OTTAWA, ON K2E 7W6, CANADA
SN 1715-5312
EI 1715-5320
J9 APPL PHYSIOL NUTR ME
JI Appl. Physiol. Nutr. Metab.
PD MAR
PY 2013
VL 38
IS 3
BP 259
EP 267
DI 10.1139/apnm-2012-0416
PG 9
WC Nutrition & Dietetics; Physiology; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics; Physiology; Sport Sciences
GA 116CP
UT WOS:000316860500005
PM 23537016
DA 2025-06-11
ER

PT J
AU Gulliver, WP
   Randell, S
   Gulliver, S
   Macdonald, D
   Gregory, V
   Nagle, S
   Chambenoit, O
AF Gulliver, Wayne P.
   Randell, Shane
   Gulliver, Susanne
   Macdonald, Don
   Gregory, Valerie
   Nagle, Sean
   Chambenoit, Olivier
TI An Investigation of Comorbid Disease and Health Service Utilization
   Among Patients With Moderate to Severe Psoriasis in Newfoundland and
   Labrador
SO JOURNAL OF CUTANEOUS MEDICINE AND SURGERY
LA English
DT Article
DE psoriasis; comorbidity; cardiovascular; inflammatory; depression;
   biologic
ID QUALITY-OF-LIFE; LONG-TERM PROGNOSIS; ETANERCEPT; EFALIZUMAB; ARTHRITIS;
   THERAPY; BURDEN; NEED
AB Psoriasis is an inflammatory skin condition affecting 2% to 3% of the population and is associated with several comorbidities, including cardiovascular disease, depression, inflammatory bowel disease, metabolic syndrome, mood disorder, psoriatic arthritis, and weight gain. Psoriasis is treated with a number of topical and systemic therapies, including biologic drugs that directly target proinflammatory cytokines. This cross-sectional retrospective study investigated comorbid conditions reported in the Newfoundland and Labrador psoriasis population, outcomes associated with therapeutic treatment, and use of health care resources. Of the psoriasis comorbidities investigated, psoriatic arthritis was significantly associated with the use of biologic therapy while a failure to respond to biologics was associated with a higher incidence of cardiovascular disease. Patients responsive to biologic treatment had fewer hospital stays than patients treated with other therapies. Our results suggest that biologic therapies have a cardioprotective effect and reduce the number of hospital visits in patients whose symptoms are responsive to treatment.
C1 [Gulliver, Wayne P.; Randell, Shane; Gulliver, Susanne] Newlab Clin Res, 187 LeMarchant Rd, St John, NB AIC 2H5, Canada.
   [Gulliver, Wayne P.] Mem Univ Newfoundland, Fac Med, Dept Med, St John, NB, Canada.
   [Macdonald, Don] Newfoundland & Labrador Ctr Hlth Informat, St John, NF, Canada.
   [Gregory, Valerie] Novartis Pharmaceut Canada, Dorval, PQ, Canada.
   [Nagle, Sean] Novartis Latin Amer Serv, Miami, FL USA.
   [Chambenoit, Olivier] Novartis Pharmaceut, E Hanover, NJ USA.
C3 Memorial University Newfoundland; Novartis; Novartis USA
RP Randell, S (corresponding author), Newlab Clin Res, 187 LeMarchant Rd, St John, NB AIC 2H5, Canada.
EM srandell@newlabresearch.com
RI Gulliver, Professor Wayne/ACM-2713-2022; Gulliver, Susanne R/O-5491-2018
OI Gulliver, Susanne R/0000-0002-3886-8740; Gulliver,
   Wayne/0000-0002-5990-232X; Randell, Shane/0009-0001-4314-240X
CR Abuabara K, 2011, BRIT J DERMATOL, V165, P1066, DOI 10.1111/j.1365-2133.2011.10525.x
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NR 23
TC 3
Z9 3
U1 0
U2 1
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1203-4754
EI 1615-7109
J9 J CUTAN MED SURG
JI J. Cutan. Med. Surg.
PD JAN-FEB
PY 2019
VL 23
IS 1
BP 29
EP 34
DI 10.1177/1203475418791114
PG 6
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA HH6YI
UT WOS:000455876900003
PM 30041544
DA 2025-06-11
ER

PT J
AU Phillips, OR
   Onopa, AK
   Zaiko, YV
   Singh, MK
AF Phillips, Owen R.
   Onopa, Alexander K.
   Zaiko, Yevgeniya V.
   Singh, Manpreet K.
TI Insulin resistance is associated with smaller brain volumes in a
   preliminary study of depressed and obese children
SO PEDIATRIC DIABETES
LA English
DT Article
DE brain; depression; insulin; metabolism; obesity
ID METABOLIC SYNDROME; DIABETES-MELLITUS; CEREBRAL-CORTEX; GRAY-MATTER;
   DISORDERS; PREVALENCE; SYMPTOMS; YOUTH; RISK
AB Objective: During childhood, the brain can consume up to 65% of total calories, and a steady supply of the brain's main fuel glucose needs to be maintained. Although the brain itself is not dependent on insulin for the uptake of glucose, insulin plays an important role in energy homeostasis. Thus, the risk for insulin resistance during brain development may negatively impact the whole brain volume.
   Methods: We investigated the link between the insulin resistance and the whole brain volume as measured by structural Magnetic resonance imaging (MRI) in 46 unmedicated depressed and overweight youths between the ages of 9 and 17 years.
   Results: Smaller whole brain volumes were associated with insulin resistance independent of age, sex, depression severity, body mass index, socioeconomic status, Tanner Stage, and Intelligence quotient (IQ) (r = 0.395, P = .014)
   Conclusions: There may be a significant cost for developing insulin resistance on the developing brain. Disentangling the precise relationship between the insulin resistance and the developing brain is critical.
C1 [Phillips, Owen R.; Onopa, Alexander K.; Zaiko, Yevgeniya V.; Singh, Manpreet K.] Stanford Univ, Sch Med, Stanford Pediat Mood Disorders Program, Dept Psychiat,Div Child & Adolescent Psychiat, Stanford, CA 94305 USA.
C3 Stanford University
RP Phillips, OR (corresponding author), Stanford Pediat Mood Disorders Program, Div Child & Adolescent Psychiat, 401 Quarry Rd, Stanford, CA 94305 USA.
EM Owenp@Stanford.edu
RI Phillips, Owen/J-3651-2017; Singh, Manpreet/L-1068-2014
OI Phillips, Owen/0000-0002-5391-707X; Singh, Manpreet/0000-0002-4373-3293
FU National Institute of Mental Health [R01MH106581]
FX National Institute of Mental Health, Grant/Award Number: R01MH106581
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   World Health Organization, 2017, WHOMSDMER20172
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NR 55
TC 11
Z9 11
U1 1
U2 8
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1399-543X
EI 1399-5448
J9 PEDIATR DIABETES
JI Pediatr. Diabetes
PD AUG
PY 2018
VL 19
IS 5
BP 892
EP 897
DI 10.1111/pedi.12672
PG 6
WC Endocrinology & Metabolism; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Pediatrics
GA GL4PO
UT WOS:000437136500005
PM 29569318
OA Green Accepted, gold
DA 2025-06-11
ER

PT J
AU Lu, Y
   Wang, PX
   Lan, N
   Kong, F
   Abdumijit, A
   Tu, SY
   Li, YT
   Yuan, WZ
AF Lu, Ying
   Wang, Pinxiu
   Lan, Ning
   Kong, Fei
   Abdumijit, Awaguli
   Tu, Shiyan
   Li, Yanting
   Yuan, Wenzhen
TI Metabolic Syndrome Predicts Response to Neoadjuvant Chemotherapy in
   Breast Cancer
SO FRONTIERS IN ONCOLOGY
LA English
DT Article
DE breast cancer; metabolic syndrome; neoadjuvant chemotherapy; efficacy
   prediction; MP grading; RECIST criteria
ID RECEIVING NEOADJUVANT; LACTATE-DEHYDROGENASE; INSULIN-RESISTANCE;
   OXIDATIVE STRESS; URIC-ACID; OBESITY; IMPACT; SURVIVAL; CELLS
AB PurposeThis research investigated the predictive role of metabolic syndrome (MetS) in breast cancer neoadjuvant chemotherapy (BCNACT) response. MethodsOne hundred fifty primary breast cancer (BC) patients who underwent neoadjuvant chemotherapy (NACT) were included retrospectively. MetS, MetS components [waist circumference (WC), fasting blood glucose (FBG), blood pressure, triglycerides (TG), and high-density lipoprotein cholesterol (HDL-C)], serum lipid, and other MetS-related laboratory indicators within two weeks before BCNACT were evaluated. Univariate, multivariate, and subgroup analyses were performed to determine the predictors of BCNACT pathologic complete response (pCR), clinical response, and pathologic response. The effectiveness of the model was evaluated via receiver operating characteristic curve (ROC) and calibration curve. External validation was performed through 135 patients. ResultsUnivariate analysis revealed that MetS before BCNACT predicted poor BCNACT response (pCR, P = 0.003; clinical response, P = 0.033; pathologic response, P < 0.001). Multivariate analysis confirmed that MetS before BCNACT predicted lower pCR rate (P = 0.041). Subgroup analysis showed that this relationship was significant in estrogen receptor (ER) (-) (RR = 0.266; 95% CI, 0.074-0.954), human epidermal growth factor 2 (HER2) (-) (RR = 0.833; 95% CI, 0.740-0.939) and TNBC (RR = 0.833; 95% CI, 0.636-0.995). Multivariate analysis of external validation confirmed that pretreatment MetS was associated with a lower pCR rate (P = 0.003), and subgroup analysis also confirmed that this relationship had significant statistical differences in ER (-), HER2 (-), and TNBC subgroups. ConclusionsMetS before BCNACT predicted a lower pCR rate. Intervention on MetS status, especially in ER (-), HER2 (-), and TNBC subgroups, is expected to improve the response rate of BCNACT further.
C1 [Lu, Ying; Wang, Pinxiu; Lan, Ning; Kong, Fei; Abdumijit, Awaguli; Tu, Shiyan; Li, Yanting] Lanzhou Univ, Sch Clin Med 1, Lanzhou, Peoples R China.
   [Yuan, Wenzhen] Lanzhou Univ, Dept Oncol, Hosp 1, Lanzhou, Peoples R China.
C3 Lanzhou University; Lanzhou University
RP Yuan, WZ (corresponding author), Lanzhou Univ, Dept Oncol, Hosp 1, Lanzhou, Peoples R China.
EM yuanwzh@lzu.edu.cn
RI Kong, Fei/KIB-6351-2024; 袁, 文臻/JRX-2086-2023
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NR 43
TC 8
Z9 8
U1 0
U2 14
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2234-943X
J9 FRONT ONCOL
JI Front. Oncol.
PD JUL 1
PY 2022
VL 12
AR 899335
DI 10.3389/fonc.2022.899335
PG 15
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA 3B6EP
UT WOS:000828032000001
PM 35847887
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Nowrouzi-Sohrabi, P
   Hassanipour, S
   Sisakht, M
   Daryabeygi-Khotbehsara, R
   Savardashtaki, A
   Fathalipour, M
AF Nowrouzi-Sohrabi, Peyman
   Hassanipour, Soheil
   Sisakht, Mohsen
   Daryabeygi-Khotbehsara, Reza
   Savardashtaki, Amir
   Fathalipour, Mohammad
TI The effectiveness of pistachio on glycemic control and insulin
   sensitivity in patients with type 2 diabetes, prediabetes and metabolic
   syndrome: A systematic review and meta-analysis
SO DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS
LA English
DT Review
DE Pistachio nuts; Type 2 diabetes; Prediabetes; Metabolic syndrome; Review
ID HOMEOSTASIS MODEL ASSESSMENT; MONOUNSATURATED FATTY-ACIDS; ENDOTHELIAL
   FUNCTION; GLUCOSE-METABOLISM; OXIDATIVE STRESS; NUT CONSUMPTION;
   BODY-WEIGHT; RESISTANCE; INFLAMMATION; RISK
AB Background and aims: Pistachio nuts have been considered to improve dysglycemia. However, there are controversial results. This systematic review and meta-analysis carried out to evaluate the effects of pistachio nuts on glycemic control and insulin sensitivity in patients with type 2 diabetes mellitus (T2DM), prediabetes, and metabolic syndrome.
   Methods: Medline/PubMed, ProQuest, Web of Knowledge, Scopus, Cochrane library, and ScienceDirect were systematically searched to find randomized controlled trials (RCTs). Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) checklist was used to conduct the study.
   Results: Six RCTs were included in the review. Treatment with pistachio nuts exerted a significant reduction in fasting blood glucose (FBG) level (OR = 1.7, 95% CI; 1.2e2.4, P = 0.002, I-2 = 0.0%, P = 0.731) and homeostasis model assessment of insulin resistance (HOMA-IR) index (OR = 1.5, 95% CI; 1.0-2.4, P = 0.043, I-2 = 0.0%, P = 0.617), but no significant improvement was observed in regard to hemoglobin A1c (HbA1c) level (OR = 1.4, 95% CI; 0.9-2.1 P = 0.089, I-2 = 0.0%, P = 0.957) and fasting plasma insulin (FPI) level (OR = 1.3, 95% CI; 0.9-1.9, P = 0.133, I-2 = 0.0%, P = 0.776).
   Conclusions: Pistachio nuts might cause a significant reduction in FBG and HOMA-IR, although HbA1c and FPI might not significantly improve in patients suffering from or at risk of T2DM. (c) 2020 Diabetes India. Published by Elsevier Ltd. All rights reserved.
C1 [Nowrouzi-Sohrabi, Peyman; Sisakht, Mohsen] Shiraz Univ Med Sci, Student Res Comm, Shiraz, Iran.
   [Hassanipour, Soheil] Guilan Univ Med Sci, Gastrointestinal & Liver Dis Res Ctr, Rasht, Iran.
   [Daryabeygi-Khotbehsara, Reza] Deakin Univ, Inst Phys Act & Nutr, Geelong, Vic, Australia.
   [Savardashtaki, Amir] Shiraz Univ Med Sci, Fac Adv Med Sci & Technol, Dept Med Biotechnol, Shiraz, Iran.
   [Fathalipour, Mohammad] Hormozgan Univ Med Sci, Fac Pharm, Dept Pharmacol & Toxicol, Bandar Abbas, Iran.
   [Fathalipour, Mohammad] Hormozgan Univ Med Sci, Endocrinol & Metab Res Ctr, Bandar Abbas, Iran.
C3 Shiraz University of Medical Science; Guilan University of Medical
   Sciences; Deakin University; Shiraz University of Medical Science
RP Fathalipour, M (corresponding author), Hormozgan Univ Med Sci, Fac Pharm, Dept Pharmacol & Toxicol, Bandar Abbas, Iran.
EM M.fathalipour@Hums.ac.ir
RI Daryabeygi-Khotbehsara, Reza/AAK-1110-2021; Hassanipour,
   Soheil/JAC-9443-2023; Savardashtaki, Amir/M-6041-2018; Daryabeygi,
   Reza/H-6122-2013; Fathalipour, Mohammad/L-9204-2016
OI Daryabeygi, Reza/0000-0003-4064-978X; Fathalipour,
   Mohammad/0000-0002-4568-7024; Nowrouzi-Sohrabi,
   Peyman/0000-0002-9720-2025
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NR 43
TC 18
Z9 19
U1 4
U2 8
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1871-4021
EI 1878-0334
J9 DIABETES METAB SYND
JI Diabetes Metab. Syndr.-Clin. Res. Rev.
PD SEP-OCT
PY 2020
VL 14
IS 5
BP 1589
EP 1595
DI 10.1016/j.dsx.2020.07.052
PG 7
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA OG9KS
UT WOS:000582194300153
PM 32947760
DA 2025-06-11
ER

PT J
AU Kir, S
   Ekiz, K
   Alacam, H
   Turkel, R
   Koroglu, E
   Altintop, BL
AF Kir, S.
   Ekiz, K.
   Alacam, H.
   Turkel, R.
   Koroglu, E.
   Altintop, B. L.
TI THE ASSOCIATION BETWEEN PRO AND ANTI-INFLAMMATORY MARKERS WITH THE
   COMPONENTS OF METABOLIC SYNDROME
SO ACTA ENDOCRINOLOGICA-BUCHAREST
LA English
DT Article
DE Metabolic syndrome; inflammatory markers; abdominal obesity;
   hypertension; hyperglycemia; hypertriglyceridemia
ID TUMOR-NECROSIS-FACTOR; ADIPOSE-TISSUE; INSULIN ACTION; ADHESION
   MOLECULES; ALPHA LEVELS; TNF-ALPHA; ADIPONECTIN; INTERLEUKIN-6;
   INFLAMMATION; OBESE
AB Objectives. Metabolic syndrome (MetS) is a cluster of metabolic abnormalities that is linked with increased circulating markers of oxidative stress and low-grade inflammation. The link between inflammation and MetS is not yet fully understood. We aim to evaluate the relationship between the levels of pro and anti-inflammatory markers such as apolipoprotein A1 (Apo-A1), apolipoprotein B (Apo-B), interleukin (IL) 6, tumor necrosis factor alpha (TNF-alpha), fibrinogen and complement component 3 (C3) and adiponectin and MetS/MetS components.
   Methods. This study was a case-control study conducted in an outpatient internal medicine clinic of the Ondokuz Mayis University Internal Medicine Department. A total of 108 subjects (59 female, 49 male) who were not under any dietary restrictions and older than 17 years were selected and divided into two groups (54 with MetS and 54 healthy controls).
   Results. Increased levels of IL-6, C3 and Apo-B/Apo-A1 ratios and decreased levels of Apo-A1 and TNF-alpha (except in patients with hypertriglyceridemia) were detected in the MetS group. Apo-A1 and TNF-alpha exhibited decreased levels, and IL-6, fibrinogen, C3 and Apo-B levels and Apo-B/Apo-A1 ratios increased as higher numbers of MetS criteria were met in the total study group.
   Conclusions. We found that inflammatory marker levels were not affected by an increased number of MetS criteria met in the MetS group although these levels increased in the control group with higher numbers of MetS components. The presence of a high number of MetS components does not have an additive pro-inflammatory contribution for subjects already diagnosed with MetS.
C1 [Kir, S.; Ekiz, K.; Turkel, R.; Koroglu, E.; Altintop, B. L.] Ondokuz Mayis Univ, Fac Med, Dept Internal Med, Samsun, Turkey.
   [Alacam, H.] Ondokuz Mayis Univ, Fac Med, Dept Biochem, Samsun, Turkey.
C3 Ondokuz Mayis University; Ondokuz Mayis University
RP Kir, S (corresponding author), Ondokuz Mayis Univ, Fac Med, Dept Internal Med, TR-55200 Atakum, Samsun, Turkey.
EM seherkr@yahoo.com
RI KIR, Seher/ABG-5244-2020
OI KIR, Seher/0000-0003-2835-1745
FU Ondokuz Mayis University scientific research fund
FX This research is supported by Ondokuz Mayis University scientific
   research fund.
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NR 34
TC 11
Z9 12
U1 0
U2 1
PU EDITURA ACAD ROMANE
PI BUCURESTI
PA CALEA 13 SEPTEMBRIE NR 13, SECTOR 5, BUCURESTI 050711, ROMANIA
SN 1841-0987
EI 1843-066X
J9 ACTA ENDOCRINOL-BUCH
JI Acta Endocrinol.
PD OCT-DEC
PY 2019
VL 15
IS 4
BP 430
EP 435
DI 10.4183/aeb.2019.430
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA LY2KH
UT WOS:000540348500003
PM 32377238
OA Green Published
DA 2025-06-11
ER

PT J
AU Simunovic, M
   Supe-Domic, D
   Karin, Z
   Degoricija, M
   Paradzik, M
   Bozic, J
   Unic, I
   Skrabic, V
AF Simunovic, Marko
   Supe-Domic, Daniela
   Karin, Zeljka
   Degoricija, Marina
   Paradzik, Martina
   Bozic, Josko
   Unic, Ivana
   Skrabic, Veselin
TI Serum catestatin concentrations are decreased in obese children and
   adolescents
SO PEDIATRIC DIABETES
LA English
DT Article
DE adolescents; catestatin; children; metabolic syndrome; obesity
ID INHIBITORY PEPTIDE CATESTATIN; CHROMOGRANIN-A FRAGMENT; CARDIOVASCULAR
   RISK-FACTORS; CATECHOLAMINE-RELEASE; METABOLIC SYNDROME;
   INSULIN-RESISTANCE; PLASMA CATESTATIN; PUBERTAL CHANGES; BLOOD-PRESSURE;
   PREVALENCE
AB Background Catestatin is a chromogranin A-derived peptide with a wide spectrum of biological activities, such as inhibiting catecholamine release, decreasing blood pressure, stimulating histamine release, reducing beta-adrenergic stimulation, and regulating oxidative stress. Objectives The aims of our study were to determine serum catestatin concentrations in obese children and adolescents in regard to presence or absence of metabolic syndrome (MS) and to evaluate the possible relations between catestatin levels and other cardiovascular risk factors. Subjects Ninety-two obese subjects with a body mass index z score > 2, aged 10 to 18 years, and 39 healthy, normal weight controls were enrolled in the study. Methods Serum catestatin concentrations were measured using an enzyme-linked immunosorbent assay. Results Significantly lower serum catestatin concentrations were recorded in the group of obese subjects compared with a control group (10.03 +/- 5.05 vs 13.13 +/- 6.25 ng/mL, P = 0.004). Further analyses revealed significantly lower catestatin concentrations in the subgroup of obese patients with MS (9.02 +/- 4.3 vs 10.54 +/- 5.36 vs 13.13 +/- 6.25, P = 0.008). Serum catestatin concentrations were significantly negatively correlated with diastolic blood pressure (r = -0.253, P = 0.014), homeostatic model assessment of insulin resistance (r = -0.215, P = 0.037) and high sensitivity C-reactive protein (r = -0.208, P = 0.044). Conclusions To the best of our knowledge, this study is the first to report catestatin concentrations in obese children and adolescents and their possible relations with MS and cardiovascular risk factors in a pediatric population. Obese subjects with MS have lower serum catestatin concentrations than obese subjects without MS and controls.
C1 [Simunovic, Marko; Unic, Ivana; Skrabic, Veselin] Univ Hosp Split, Dept Pediat, Spinciceva 1, Split 21000, Croatia.
   [Supe-Domic, Daniela] Univ Hosp Split, Dept Med Lab Diagnost, Split, Croatia.
   [Karin, Zeljka] Publ Hlth Inst Split & Dalmatia Cty, Split, Croatia.
   [Degoricija, Marina] Univ Split, Dept Med Chem & Biochem, Sch Med, Split, Croatia.
   [Paradzik, Martina] Univ Hosp Split, Dept Ophthalmol, Split, Croatia.
   [Bozic, Josko] Univ Split, Dept Pathophysiol, Sch Med, Split, Croatia.
C3 University of Split; University of Split; University of Split;
   University of Split; University of Split
RP Simunovic, M (corresponding author), Univ Hosp Split, Dept Pediat, Spinciceva 1, Split 21000, Croatia.
EM markosimunovic@hotmail.com
RI škrabić, veselin/D-5564-2017; Šupe-Domić, Daniela/Y-3169-2019;
   Degoricija, Marina/D-5578-2017; Bozic, Josko/E-1866-2017
OI Bozic, Josko/0000-0003-1634-0635; Skrabic, Veselin/0000-0001-9434-5306;
   Supe Domic, Daniela/0000-0002-5584-3182; Degoricija,
   Marina/0000-0001-7023-9381
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NR 56
TC 26
Z9 26
U1 1
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1399-543X
EI 1399-5448
J9 PEDIATR DIABETES
JI Pediatr. Diabetes
PD AUG
PY 2019
VL 20
IS 5
BP 549
EP 555
DI 10.1111/pedi.12825
PG 7
WC Endocrinology & Metabolism; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Pediatrics
GA II7WO
UT WOS:000475402500007
PM 30714297
OA gold
DA 2025-06-11
ER

PT J
AU Silva, JCP
   Jones, JG
AF Silva, Joao C. P.
   Jones, John G.
TI Improving Metabolic Control Through Functional Foods
SO CURRENT MEDICINAL CHEMISTRY
LA English
DT Review
DE Insulin sensitivity; type 2 diabetes; non-alcoholic fatty liver disease;
   inflammation; short-chain fatty acids; mitochondrial uncoupling
ID POLYUNSATURATED FATTY-ACIDS; OAT BETA-GLUCAN; INSULIN SENSITIVITY;
   OXIDATIVE STRESS; KETOGENIC DIET; ADIPOSE-TISSUE; KETONE-BODIES;
   RESVERATROL SUPPLEMENTATION; LIPID-PEROXIDATION; GLUCOSE-TOLERANCE
AB Background: Functional foods are designed to have physiological benefits and reduce the risk of chronic disease beyond basic nutritional functions. Conditions related to overnutrition such as Metabolic Syndrome and Type 2 diabetes are increasingly serious concerns in Western societies. Several nutrient classes are considered to protect against these conditions and this review focuses on the latest clinical and preclinical evidence supporting their efficacy and the molecular mechanisms by which they act.
   Methods: The review searched the literature for information and data on the following functional food components and their protective effects against Metabolic Syndrome and Type 2 Diabetes: Dietary fiber; Medium-chain triglycerides and Ketone esters; omega 3 Polyunsaturated fatty acids and Antioxidants.
   Results: Data from a hundred and four studies were reviewed and summarized. They indicate that dietary fiber results in the production of beneficial short chain fatty acids via intestinal microbiota, as well as increasing intestinal secretion of incretins and satiety peptides. Medium chain triglycerides and ketone esters promote thermogenesis, inhibit lipolysis and reduce inflammation. They also decrease endogenous synthesis of triglycerides and fatty acids. omega 3-PUFA's act to soften inflammation through an increase in adiponectin secretion. Antioxidants are involved in the protection of insulin sensitivity by PTP1B suppression and SIRT1 activation.
   Conclusion: Functional foods have actions that complement and/or potentiate other lifestyle interventions for reversing Metabolic Syndrome and Type 2 Diabetes. Functional foods contribute to reduced food intake by promoting satiety, less weight gain via metabolic uncoupling and improved insulin sensitivity via several distinct mechanisms.
C1 [Silva, Joao C. P.; Jones, John G.] UC Biotech, Ctr Neurosci & Cell Biol, Biocant Pk, Cantanhede, Portugal.
   [Jones, John G.] APDP Portuguese Diabet Assoc, Lisbon, Portugal.
C3 Universidade de Coimbra
RP Jones, JG (corresponding author), UC Biotech, Ctr Neurosci & Cell Biol, Biocant Pk, Cantanhede, Portugal.
EM john.griffith.jones@gmail.com
RI Jones, John/A-8684-2010
OI Jones, John/0000-0002-3745-3885
FU Portuguese Foundation for Science and Technology [EXCL/DTP/0069/2012,
   PEst-C/SAU/LA0001/2011, CENTRO-07-CT62-FEDER-002012]; FEDER - European
   Regional Development Fund through the COMPETE Programme
FX Financial support from the Portuguese Foundation for Science and
   Technology (research grant EXCL/DTP/0069/2012). Structural funding for
   the Center for Neurosciences is supported in part by FEDER - European
   Regional Development Fund through the COMPETE Programme and the
   Portuguese Foundation for Science and Technology through grants
   PEst-C/SAU/LA0001/2011 and CENTRO-07-CT62-FEDER-002012.
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NR 104
TC 8
Z9 8
U1 3
U2 40
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 0929-8673
EI 1875-533X
J9 CURR MED CHEM
JI Curr. Med. Chem.
PY 2019
VL 26
IS 19
BP 3424
EP 3438
DI 10.2174/0929867324666170523130123
PG 15
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Pharmacology &
   Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
GA IX6HC
UT WOS:000485782800004
PM 28545368
DA 2025-06-11
ER

PT J
AU Lee, JH
   Seo, DH
   Nam, MJ
   Lee, GH
   Yang, DH
   Lee, MJ
   Choi, UR
   Hong, S
AF Lee, Jung Hwan
   Seo, Da Hea
   Nam, Min Jung
   Lee, Geon Hui
   Yang, Dong Hee
   Lee, Min Joo
   Choi, Ung-Rim
   Hong, Seongbin
TI The Prevalence of Obesity and Metabolic Syndrome in the Korean Military
   Compared with the General Population
SO JOURNAL OF KOREAN MEDICAL SCIENCE
LA English
DT Article
DE Metabolic Syndrome; Obesity; Military; Cross-sectional Survey
ID BODY-MASS INDEX; NUTRITION EXAMINATION SURVEY; CIGARETTE-SMOKING;
   RISK-FACTORS; CARDIOVASCULAR RISK; NATIONAL-HEALTH; BRITISH ARMY;
   HYPERTENSION; US; ASSOCIATION
AB Background: Obesity and related metabolic disorders are growing health challenges worldwide and individuals at military service are not exceptions. The purpose of this study was to examine the prevalence of obesity and metabolic syndrome (MS) in the Korean military and to compare with the general population.
   Methods: This was a cross-sectional study of 4,803 young military participants who underwent a corporal health-screening program between October 2013 and October 2014. The National Cholesterol Education Program Adult Treatment Panel III criteria was used to identify MS. We also sampled 1,108 men aged 19-29 years from the Korea National Health and Nutritional Examination Survey from 2010 to 2013 to compare with their military counterparts.
   Results: The mean age of military participants was 20.8 +/- 1.1 years, and 20.6% (n = 988) were obese. The prevalence of MS was 0.8% in military participants, while 7.9% in general population. The risk factors of MS were less prominent among military participants relative to civilians, with the exception of high blood pressure, of which prevalence was higher among military participants (21.5% vs. 18.2%, respectively). In multiple logistic analysis, high physical activity conferred lower odds of MS and obesity in military participants (odds ratios, 0.19 and 0.81, respectively). Age older than 25 years increased risk of most components of MS among civilians.
   Conclusion: The prevalence of obesity and MS is lower in military participants compared with civilians of similar age. Monitoring of high blood pressure and proper stress management are warranted in those at military service.
C1 [Lee, Jung Hwan; Nam, Min Jung; Lee, Geon Hui; Yang, Dong Hee; Lee, Min Joo; Choi, Ung-Rim] Republ Korea Armed Forces, Med Battal, Div 5, Yeoncheon, South Korea.
   [Lee, Jung Hwan; Seo, Da Hea; Hong, Seongbin] Inha Univ, Sch Med, Dept Internal Med, Inha Univ Hosp,Div Endocrinol & Metab, 27 Inhang Ro, Incheon 22332, South Korea.
C3 Inha University; Inha University Hospital
RP Hong, S (corresponding author), Inha Univ, Sch Med, Dept Internal Med, Inha Univ Hosp,Div Endocrinol & Metab, 27 Inhang Ro, Incheon 22332, South Korea.
EM sbhongmd@inha.ac.kr
RI Rhee, Yumie/L-8020-2019; Lee, Kee-Joon/AAA-4090-2022
OI Hong, Seongbin/0000-0002-8189-395X; Seo, Da Hea/0000-0003-2767-0293
FU Korean Military Medical Research Program [2014-KMMRP-015]; Inha
   University Research Grant
FX This research was supported by Korean Military Medical Research Program
   (Grant number: 2014-KMMRP-015) and Inha University Research Grant.
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NR 39
TC 12
Z9 13
U1 0
U2 4
PU KOREAN ACAD MEDICAL SCIENCES
PI SEOUL
PA 302 75 DONG DU ICHON, DONG YONGSAN KU, SEOUL 140 031, SOUTH KOREA
SN 1011-8934
EI 1598-6357
J9 J KOREAN MED SCI
JI J. Korean Med. Sci.
PD JUN 18
PY 2018
VL 33
IS 25
AR e172
DI 10.3346/jkms.2018.33.e172
PG 11
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA GJ8JU
UT WOS:000435636500002
PM 29915523
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Yadav, D
   Lee, MY
   Kim, JY
   Ryu, H
   Huh, JH
   Bae, KS
   Ahn, SV
   Chung, CH
   Park, JT
   Koh, SB
AF Yadav, Dhananjay
   Lee, Mi Young
   Kim, Jang Young
   Ryu, Hoon
   Huh, Ji Hye
   Bae, Keum Seok
   Ahn, Song Vogue
   Chung, Choon Hee
   Park, Jong Taek
   Koh, Sang Baek
TI Combined Effect of Initial and Longitudinal Increases in
   γ-Glutamyltransferase on Incident Metabolic Syndrome: ARIRANG Study
SO YONSEI MEDICAL JOURNAL
LA English
DT Article
DE gamma-glutamyltransferase; cohort; metabolic syndrome
ID BODY-MASS INDEX; C-REACTIVE PROTEIN; CARDIOVASCULAR-DISEASE; OXIDATIVE
   STRESS; WAIST CIRCUMFERENCE; INSULIN-RESISTANCE; RISK; OBESITY;
   ASSOCIATION; PREDICTOR
AB Purpose: Although gamma-glutamyltransferase (GGT) is well known to be associated with metabolic syndrome (MS), prospective data on baseline and longitudinal changes in GGT levels and incident cases of MS are limited. We aimed to examine prospective associations between changes in GGT levels over time, as well as at baseline, and incident MS in Korean adults.
   Materials and Methods: A total of 2579 Korean adults free of MS were followed up for 2.6 years. Data were collected from 20052008 (baseline) and from 2008-2011 (follow-up). Serum GGT levels were determined by enzymatic methods.
   Results: During follow-up, 558 participants (21.6%) developed MS. A gradual increase in the incidence of MS was observed across GGT quartiles. After adjustment for confounding factors, the odds ratio and 95% confidence interval (CI) for new onset MS, comparing the highest to the lowest quartiles of baseline GGT, was 2.07 (95% CI: 1.52-2.80). The odds ratio for the highest GGT changes (>4 IU/L increase) in comparison to the lowest GGT changes (<-5 IU/L decrease) was 1.75 (95% CI: 1.32-2.33). Among participants with baseline GGT concentrations <the median, the odds ratio for incident MS, comparing participants with the highest GGT changes with the lowest GGT changes, was 1.52 (95% CI: 1.01-2.31). Among participants with baseline GGT concentration >= the median, the corresponding odds ratio was 2.75 (95% CI: 1.84-4.10).
   Conclusion: High initial GGT concentration and increases in GGT concentration over time should be considered independent predictors of and to have a combined effect on incident MS.
C1 [Yadav, Dhananjay; Ahn, Song Vogue; Koh, Sang Baek] Yonsei Univ, Wonju Coll Med, Dept Prevent Med, Wonju, South Korea.
   [Lee, Mi Young; Kim, Jang Young; Huh, Ji Hye; Chung, Choon Hee] Yonsei Univ, Wonju Coll Med, Dept Internal Med, Wonju, South Korea.
   [Ryu, Hoon; Bae, Keum Seok] Yonsei Univ, Wonju Coll Med, Dept Surg, Wonju, South Korea.
   [Park, Jong Taek] Yonsei Univ, Wonju Coll Med, Dept Anesthesiol & Pain Med, 20 Ilsan Ro, Wonju 26426, South Korea.
C3 Yonsei University; Yonsei University; Yonsei University; Yonsei
   University
RP Park, JT (corresponding author), Yonsei Univ, Wonju Coll Med, Dept Anesthesiol & Pain Med, 20 Ilsan Ro, Wonju 26426, South Korea.; Kim, JY (corresponding author), Yonsei Univ, Wonju Coll Med, Div Cardiol, Dept Internal Med, 20 Ilsan Ro, Wonju 26426, South Korea.
EM kimjy@yonsei.ac.kr; jtp999@yonsei.ac.kr
RI Cho, Young/J-5669-2012; Ahn, Song/AAK-2900-2021; park, jun
   yeon/GPX-5293-2022; Yadav, Dhananjay/AAZ-9435-2021; Ryu,
   Hoon/MCJ-9411-2025; Kim, Nam Hoon/HNS-5794-2023
OI Chung, Choon/0000-0003-1144-7206
FU Korea Centers for Disease Control and Prevention [2005-E71013-00,
   2006-E71002-00, 2007-E71013-00, 2008-E71004-00, 2009-E71006-00,
   2010-E71003-00]
FX This study was supported in part by a grant from the Korea Centers for
   Disease Control and Prevention (2005-E71013-00, 2006-E71002-00,
   2007-E71013-00, 2008-E71004-00, 2009-E71006-00, 2010-E71003-00).
CR Abete I, 2011, NUTR METAB CARDIOVAS, V21, pB1, DOI 10.1016/j.numecd.2011.05.001
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NR 34
TC 8
Z9 9
U1 0
U2 1
PU YONSEI UNIV COLL MEDICINE
PI SEOUL
PA 50-1 YONSEI-RO, SEODAEMUN-GU, SEOUL 120-752, SOUTH KOREA
SN 0513-5796
EI 1976-2437
J9 YONSEI MED J
JI Yonsei Med. J.
PD JUL
PY 2017
VL 58
IS 4
BP 763
EP 769
DI 10.3349/ymj.2017.58.4.763
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA FD8AL
UT WOS:000407747400012
PM 28540989
OA gold, Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Ruan, YP
   Wei, WL
   Yan, JH
   Sun, LX
   Lian, H
   Zhao, XY
   Liang, RJ
   Liu, XL
   Fan, ZJ
AF Ruan, Yanping
   Wei, Wanlin
   Yan, Jianhua
   Sun, Lixian
   Lian, Hui
   Zhao, Xiaoyi
   Liang, Ruijuan
   Liu Xiaole
   Fan, Zhongjie
TI Time Rate of Blood Pressure Variation Is Associated With Endothelial
   Function in Patients With Metabolic Syndrome
SO INTERNATIONAL HEART JOURNAL
LA English
DT Article
DE RHI; Ambulatory blood pressure monitoring; Target organ damage; Blood
   pressure variability
ID INTIMA-MEDIA THICKNESS; VISIT-TO-VISIT; CARDIOVASCULAR RISK; VASCULAR
   FUNCTION; SHEAR-STRESS; VARIABILITY; ATHEROSCLEROSIS; AMPLITUDE; IMPACT
AB The time rate of blood pressure (BP) variation indicates the speed of BP fluctuations. Previous studies have demonstrated that the time rate of BP variation was associated with target organ damage. However, the association between time rate of BP variation and endothelial function has not been evaluated.
   24-hour ambulatory blood pressure monitoring (ABPM) was performed in 61 patients with metabolic syndrome. Time rate of BP variation was calculated from BP recordings of ABPM. Endothelial function was assessed using reactive hyperemia-peripheral arterial tonometry index (RHI) by EndoPat2000. Multiple linear regression models were used to detect the association between time rate of BP variation and RHI.
   Among all the subjects (n = 61), the multiple linear regression models revealed that the daytime rate of systolic blood pressure (SBP) variation was independently associated with RHI (beta = -0.334, P = 0.008). A 0.1 mmHg/minute increase in the daytime rate of SBP variation correlated with a decline of 0.20 in RHI. The same effect was also found in the subjects with eGFR >= 60 mL/(minute*1.73 m(2)). A greater association was found in those who were not taking a statin, beta-blocker, ACEI/ARB, or diuretic and those without diabetes compared with those with any antihypertensive medication or with diabetes.
   Other ambulatory blood pressure parameters and central hemodynamics were not found to be associated with RHI. Our findings have shown that the daytime rate of SBP variation was associated with endothelial function in patients with metabolic syndrome, independent of other BP parameters and central hemodynamics.
C1 [Ruan, Yanping; Lian, Hui; Zhao, Xiaoyi; Liang, Ruijuan; Liu Xiaole; Fan, Zhongjie] Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Cardiol, Beijing 100021, Peoples R China.
   [Ruan, Yanping; Lian, Hui; Zhao, Xiaoyi; Liang, Ruijuan; Liu Xiaole; Fan, Zhongjie] Chinese Acad Med Sci, Beijing 100730, Peoples R China.
   [Wei, Wanlin] Beijing Mil Command, Gen Hosp, Dept Cardiol, Beijing, Peoples R China.
   [Yan, Jianhua] Shanghai Jiao Tong Univ, Sch Med, Xinhua Hosp, Div Cardiovasc Med, Chengde, Hebei, Peoples R China.
   [Sun, Lixian] Chengde Med Coll, Affiliated Hosp, Div Cardiovasc Med, Chengde, Hebei, Peoples R China.
C3 Chinese Academy of Medical Sciences - Peking Union Medical College;
   Peking Union Medical College; Peking Union Medical College Hospital;
   Chinese Academy of Medical Sciences - Peking Union Medical College;
   Seventh Medical Center of Chinese PLA General Hospital; Shanghai Jiao
   Tong University; Chengde Medical University
RP Fan, ZJ (corresponding author), Beijing Union Med Coll Hosp, Dept Cardiol, 1 Shuai Fu Yuan, Beijing, Peoples R China.
EM Fan@pumch.cn
CR Bonetti PO, 2003, ARTERIOSCL THROM VAS, V23, P168, DOI 10.1161/01.ATV.0000051384.43104.FC
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NR 26
TC 8
Z9 9
U1 0
U2 6
PU INT HEART JOURNAL ASSOC
PI TOKYO
PA UNIV TOKYO, GRADUATE SCHOOL MEDICINE, DEPT CARDIOVASCULAR MEDICINE,
   HONGO 7-3-1, BUNKYO-KU, TOKYO, 113-8655, JAPAN
SN 1349-2365
EI 1349-3299
J9 INT HEART J
JI Int. Heart J.
PD MAR
PY 2016
VL 57
IS 2
BP 226
EP 233
DI 10.1536/ihj.15-322
PG 8
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA DL3GS
UT WOS:000375522800017
PM 26973261
OA Bronze
DA 2025-06-11
ER

PT J
AU Yuan, ZP
   Liu, CG
   Tian, YP
   Zhang, XH
   Ye, HZ
   Jin, LF
   Ruan, LS
   Sun, ZH
   Zhu, YM
AF Yuan, Zheping
   Liu, Chengguo
   Tian, Yiping
   Zhang, Xuhui
   Ye, Huaizhuang
   Jin, Lifeng
   Ruan, Liansheng
   Sun, Zhanhang
   Zhu, Yimin
TI Higher Levels of Magnesium and Lower Levels of Calcium in Whole Blood
   Are Positively Correlated with the Metabolic Syndrome in a Chinese
   Population: A Case-Control Study
SO ANNALS OF NUTRITION AND METABOLISM
LA English
DT Article
DE Magnesium; Calcium; Ca to Mg ratio; Metabolic syndrome
ID INSULIN-RESISTANCE; PARATHYROID-HORMONE; DIABETES-MELLITUS;
   SERUM-CALCIUM; RISK-FACTORS; CARDIOVASCULAR-DISEASE; INTRACELLULAR
   CALCIUM; DIETARY MAGNESIUM; CELLULAR CALCIUM; OXIDATIVE STRESS
AB Magnesium (Mg) and calcium (Ca) are essential for numerous kinds of metabolisms in human body. To investigate the associations between Mg and Ca and the ratio of Ca to Mg (Ca/Mg) in whole blood with metabolic syndrome (MetS) in a Chinese population, a matched case-control study including 204 MetS patients and 204 healthy controls (aged 48-89) was carried out in 2011. MetS were diagnosed according to the criteria of Chinese Diabetes Society. Controls had no abnormal metabolic components and were matched with cases by age, gender and region. Blood samples were collected in the morning after an overnight fast. Whole blood Mg and Ca were determined by flame atomic absorption spectrometry. Subjects who were male constituted 44.1% of the part of this study. The average age was 64.0 +/- 7.18, and the average body mass index was 24.3 +/- 3.75. The MetS group showed significantly higher Mg and lower Ca and Ca/Mg as compared with the control group. Comparing with the bottom tertile (T1) of Mg, increased ORs for MetS were found in median tertile (T2) and top tertile (T3) of Mg. For Ca, T2 and T3 were negatively associated with MetS. Inverse relationship was also found between Ca/Mg ratio and MetS. Our findings suggested that increased Mg and decreased Ca and Ca/Mg in whole blood were correlated with MetS in Chinese adults. (C) 2016 S. Karger AG, Basel
C1 [Yuan, Zheping; Zhu, Yimin] Zhejiang Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, 866 Yu Hang Tang Rd, Hangzhou 310058, Zhejiang, Peoples R China.
   [Ye, Huaizhuang; Jin, Lifeng] Zhejiang Univ, Sch Publ Hlth, Ctr Expt Teaching, Hangzhou, Zhejiang, Peoples R China.
   [Tian, Yiping] Zhejiang Univ, Sch Med, Dept Pathol, Hangzhou, Zhejiang, Peoples R China.
   [Zhang, Xuhui] Hangzhou Ctr Dis Control & Prevent, Dept Nutr & Food Safety, Hangzhou, Zhejiang, Peoples R China.
   [Liu, Chengguo; Ruan, Liansheng; Sun, Zhanhang] Zhejiang Putuo Hosp, Dept Endocrinol & Inst Cardiovasc Dis, Zhoushan, Peoples R China.
C3 Zhejiang University; Zhejiang University; Zhejiang University
RP Zhu, YM (corresponding author), Zhejiang Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, 866 Yu Hang Tang Rd, Hangzhou 310058, Zhejiang, Peoples R China.
EM zhuym@zju.edu.cn
RI Liu, Chengguo/IUM-6475-2023; Zhu, Yimin/D-6387-2017; 张, 旭晖/HLG-4912-2023
FU National Key Technology R&D Program of China [2012BAI02B03]; National
   Natural Science Foundation of China [81172755]; Program for Zhejiang
   Leading Team of Science and Technology Innovation [2010R50050]
FX This study has been supported by National Key Technology R&D Program of
   China (2012BAI02B03), National Natural Science Foundation of China
   (81172755). Zhejiang Provincial Program for the Cultivation of
   High-Level Innovative Health Talents, Fundamental Research Funds for the
   Central Universities and Program for Zhejiang Leading Team of Science
   and Technology Innovation (2010R50050).
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NR 75
TC 22
Z9 23
U1 0
U2 6
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0250-6807
EI 1421-9697
J9 ANN NUTR METAB
JI Ann. Nutr. Metab.
PY 2016
VL 69
IS 2
BP 125
EP 134
DI 10.1159/000450761
PG 10
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA EC8UC
UT WOS:000388417300056
PM 27750224
DA 2025-06-11
ER

PT J
AU Faganello, G
   Cioffi, G
   Faggiano, P
   Candido, R
   Tarantini, L
   De Feo, S
   Di Lenarda, A
   de Simone, G
AF Faganello, Giorgio
   Cioffi, Giovanni
   Faggiano, Pompilio
   Candido, Riccardo
   Tarantini, Luigi
   De Feo, Stefania
   Di Lenarda, Andrea
   de Simone, Giovanni
TI Does metabolic syndrome worsen systolic dysfunction in diabetes? The
   shortwave study
SO ACTA DIABETOLOGICA
LA English
DT Article
DE Diabetes mellitus; Metabolic syndrome; Cardiac function; Left
   ventricular systolic function
ID CORONARY-HEART-DISEASE; LEFT-VENTRICULAR GEOMETRY; OBSTRUCTIVE
   SLEEP-APNEA; MYOCARDIAL DYSFUNCTION; CARDIOVASCULAR-DISEASE; DIASTOLIC
   FUNCTION; SYNDROME IMPACT; HIGH PREVALENCE; MELLITUS; RISK
AB Patients with metabolic syndrome (MetS) have high cardiovascular event rates. The additional effect of MetS on left ventricular (LV) systolic function in patients with type 2 diabetes mellitus (T2DM) is unknown. We studied the relation between MetS and LV systolic function in T2DM patients without coronary artery disease (CAD). Clinical and echocardiographic data from 331 T2DM patients were analyzed. Prevalence of MetS was assessed based on NCEP ATPIII definition. Stress-corrected midwall shortening (sc-MS) and mitral annular peak systolic velocity (S') were analyzed as indexes of circumferential and longitudinal shortening, respectively. Sc-MS was impaired if < 89 %, S' if < 8.5 cm/s (10th percentile of healthy controls). MetS was diagnosed in 172 patients. Sc-MS and S' were similar in T2DM patients with and without MetS (91 +/- A 14 vs 92 +/- A 15 %; 9.8 +/- A 2.0 vs 9.5 +/- A 2.1 cm/s, respectively; p = ns) but significantly reduced comparing to controls (102 +/- A 11 % and 10.8 cm/s; p < 0.0001). Impairment of sc-MS and S' were detected in 37 vs 40 % and in 29 vs 32 % of T2DM patients with and without MetS (p = ns), respectively. LV systolic function measured as sc-MS and S' is frequently impaired in T2DM patients without CAD; however, the coexistence of MetS is not associated with more severe LV systolic dysfunction. Further pathological mechanisms have to be considered to explain the negative prognostic impact of MetS in T2DM patients.
C1 [Faganello, Giorgio; Di Lenarda, Andrea] Azienda Serv Sanit 1, Cardiovasc Ctr, I-34100 Trieste, Italy.
   [Cioffi, Giovanni] Villa Bianca Hosp, Dept Cardiol, Trento, Italy.
   [Faggiano, Pompilio] Spedali Civil Brescia, Cardiol Unit, I-25125 Brescia, Italy.
   [Candido, Riccardo] Azienda Serv Sanit 1, I-34100 Trieste, Italy.
   [Tarantini, Luigi] Osped Civile S Martino, Dept Cardiol, Belluno, Italy.
   [De Feo, Stefania] Pederzolli Hosp, Dept Cardiol, Peschiera, Italy.
   [de Simone, Giovanni] Univ Hosp, Dept Translat Med Sci, Naples, Italy.
C3 Hospital Spedali Civili Brescia; ULSS 1 Dolomiti; Ospedale di Belluno
RP Faganello, G (corresponding author), Azienda Serv Sanit 1, Cardiovasc Ctr, Via Slataper 9, I-34100 Trieste, Italy.
EM giorgio.faganello@libero.it
RI Tarantini, Luigi/AAY-9493-2021; Di Lenarda, Andrea/AAC-2377-2022;
   Candido, Riccardo/AAC-4525-2022; de Simone, Giovanni/D-1767-2011
OI tarantini, luigi/0000-0003-2580-0963; de Simone,
   Giovanni/0000-0001-8567-9881
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NR 44
TC 4
Z9 4
U1 0
U2 2
PU SPRINGER-VERLAG ITALIA SRL
PI MILAN
PA VIA DECEMBRIO, 28, MILAN, 20137, ITALY
SN 0940-5429
EI 1432-5233
J9 ACTA DIABETOL
JI Acta Diabetol.
PD FEB
PY 2015
VL 52
IS 1
BP 143
EP 151
DI 10.1007/s00592-014-0620-0
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA CA9EQ
UT WOS:000349224100016
PM 25074251
DA 2025-06-11
ER

PT J
AU Li, SJ
   Liu, CH
   Chang, CW
   Chu, HP
   Chen, KJ
   Mersmann, HJ
   Ding, ST
   Chu, CH
   Chen, CY
AF Li, Sin-Jin
   Liu, Chia-Hsin
   Chang, Chei-Wei
   Chu, Hsien-Pin
   Chen, Kuen-Jaw
   Mersmann, Harry J.
   Ding, Shih-Torng
   Chu, Chun-Han
   Chen, Ching-Yi
TI Development of a dietary-induced metabolic syndrome model using
   miniature pigs involvement of AMPK and SIRT1
SO EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
LA English
DT Article
DE AMPK; Lanyu miniature pig; Lee-Sung miniature pig; metabolic syndrome;
   metabolically healthy obesity; SIRT1
ID OXIDATIVE STRESS; NONALCOHOLIC STEATOHEPATITIS; NORMAL-WEIGHT; HIGH-FAT;
   HEPATIC STEATOSIS; PORCINE MODELS; OBESE; HEALTHY; MICE; PROTECTS
AB BackgroundDuring the progression of the metabolic syndrome (MetS), cardiovascular diseases (CVD) appear clinically in many individuals and cause death. As a result, it is essential to set up an optimal animal model to study the mechanism of MetS leading to CVD. SIRT1 and AMPK are the master regulators of lipid and carbohydrate metabolism. The objective of this study was to establish a miniature pig model of Western diet-induced MetS and investigate the role of SIRT1/AMPK during MetS development.
   Materials and MethodsFive-month-old Lee-Sung (LS) and Lanyu (LY) minipigs were each randomly assigned to two groups: control diet (C) and Western diet (W), in a 6-month experimental period.
   ResultsWestern diet caused obesity in both minipig models. Compared with the CLS pigs, WLS pigs exhibited hypercholesterolaemia. However, WLY pigs maintained a similar plasma lipid profile to the CLY pigs. Western diet caused a lower antioxidant capacity in the liver of both pig models. WLS pigs had higher triglyceride accumulation in the liver than CLS pigs, whereas WLY and CLY pigs had similar hepatic triglyceride accumulation. Compared with CLS pigs, WLS pigs had a lower hepatic SIRT1 expression, whereas WLY pigs had a higher expression of AMPK, FOXO1 and SIRT1 than CLY pigs.
   ConclusionLong-term feeding of the Western diet to Lee-Sung miniature pigs not only caused obesity but also induced MetS and fatty liver, whereas Western diet induced obesity in Lanyu pigs without metabolic dysfunctions. SIRT1/AMPK and their downstream pathways might be one of the possible regulators for pathological obesity in Lee-Sung pigs.
C1 [Li, Sin-Jin; Liu, Chia-Hsin; Mersmann, Harry J.; Ding, Shih-Torng; Chu, Chun-Han; Chen, Ching-Yi] Natl Taiwan Univ, Dept Anim Sci & Technol, Taipei 106, Taiwan.
   [Chang, Chei-Wei; Chu, Hsien-Pin; Chen, Kuen-Jaw] Livestock Res Inst Council Agr, Taitung Anim Propagat Stn, Beinan Township, Taitung County, Taiwan.
   [Ding, Shih-Torng] Natl Taiwan Univ, Inst Biotechnol, Taipei 10764, Taiwan.
C3 National Taiwan University; National Taiwan University
RP Chen, CY (corresponding author), Natl Taiwan Univ, Dept Anim Sci & Technol, 50,Lane 155,Sec 3,Keelung Rd, Taipei 106, Taiwan.
EM ronichen@ntu.edu.tw
RI Liu, Chun-Yu/I-4358-2015
OI Chen, Ching-Yi/0000-0002-5776-084X; Li, Sin-Jin/0000-0002-0010-8439;
   Ding, Shih-Torng/0000-0002-9866-1776
FU National Science Council [NSC 101-2313-B-002-030-MY3]; National Taiwan
   University [NTU-CESRP-102R7615-1, NTU-CESRP-103R7615-3]
FX This work was supported by the Research Grant NSC 101-2313-B-002-030-MY3
   (from National Science Council), NTU-CESRP-102R7615-1 and
   NTU-CESRP-103R7615-3 (from National Taiwan University).
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NR 35
TC 15
Z9 16
U1 1
U2 23
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0014-2972
EI 1365-2362
J9 EUR J CLIN INVEST
JI Eur. J. Clin. Invest.
PD JAN
PY 2015
VL 45
IS 1
BP 70
EP 80
DI 10.1111/eci.12370
PG 11
WC Medicine, General & Internal; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Research & Experimental Medicine
GA AX6UO
UT WOS:000347056700009
PM 25376184
DA 2025-06-11
ER

PT J
AU El-Bassossy, HM
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AF El-Bassossy, Hany M.
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TI Heme oxygenase-1 alleviates vascular complications associated with
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SO CHEMICO-BIOLOGICAL INTERACTIONS
LA English
DT Article
DE Metabolic syndrome; Aorta; Hypertension; Haem oxygenase-1
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   CARBON-MONOXIDE; INDUCTION PROTECTS; BLOOD-PRESSURE; HYPERTENSION;
   CELLS; INHIBITION; APOPTOSIS
AB Protective effect of Heme oxygenase-1 (HO-1) induction from hypertension was previously reported in a diabetic animal model. Here, the effect of HO-1 induction on vascular complications associated with metabolic syndrome (MetS) was investigated.
   MetS was induced in rats by fructose drinking for 12 weeks while HO-1 was induced by hemin or curcumin administration in the last 6 weeks. Then, aortic HO-1 protein expression was assessed, blood pressure (BP) was recorded and serum levels of glucose and insulin were measured. Concentration response curves for phenylephrine (PE), KCI, and acetylcholine (ACh) were obtained in thoracic aortic cross sections. Aortic reactive oxygen species (ROS) and nitric oxide (NO) generation were also studied.
   Both hemin and curcumin significantly inhibited the elevated systolic and diastolic BP seen in MetS animals. While not affected by MetS, HO-1 expression was significantly increased by hemin and curcumin treatment. HO-1 induction did not affect the exaggerated vasoconstriction response to KC] and PE. However, HO-1 induction prevented the impaired relaxation and NO generation in aorta isolated from MetS animals. In addition, the HO inhibitor, tin protoporphyrin, abolished the hemin protective effect on relaxation and NO generation. HO-1 induction prevented the elevated hyperinsulinemia associated with MetS. Furthermore, HO-1 induction inhibited ROS production in aorta isolated from MetS animals.
   In conclusion, Heme oxygenase-1 alleviates vascular complications associated in MetS through maintaining endothelial-dependent relaxation and NO generation in addition to improving insulin sensitivity. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
C1 [El-Bassossy, Hany M.] King Abdulaziz Univ, Fac Pharm, Dept Pharmacol, Jeddah 21589, Saudi Arabia.
   [El-Bassossy, Hany M.; Hassan, Nadia; Zakaria, Mohamed N. M.] Zagazig Univ, Fac Pharm, Dept Pharmacol, Alexandria, Egypt.
C3 King Abdulaziz University; Egyptian Knowledge Bank (EKB); Zagazig
   University
RP El-Bassossy, HM (corresponding author), King Abdulaziz Univ, Fac Pharm, Dept Pharmacol, POB 80260, Jeddah 21589, Saudi Arabia.
EM helbassossy@kau.edu.sa
RI El-Bassossy, Hany/NKQ-3705-2025; El-Bassossy, Hany/I-1576-2012
OI El-Bassossy, Hany/0000-0002-6838-6945
CR Abraham NG, 2005, FREE RADICAL BIO MED, V39, P1, DOI 10.1016/j.freeradbiomed.2005.03.010
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NR 46
TC 18
Z9 18
U1 0
U2 2
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0009-2797
EI 1872-7786
J9 CHEM-BIOL INTERACT
JI Chem.-Biol. Interact.
PD NOV 5
PY 2014
VL 223
BP 109
EP 115
DI 10.1016/j.cbi.2014.09.014
PG 7
WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology
GA AW6RZ
UT WOS:000346397400014
PM 25268984
DA 2025-06-11
ER

PT J
AU Salem, SD
   Saif-Ali, R
   Muniandy, S
   Al-Hamodi, Z
   Ismail, IS
AF Salem, Sameer D.
   Saif-Ali, Riyadh
   Muniandy, Sekaran
   Al-Hamodi, Zaid
   Ismail, Ikram S.
TI Comparison of Adults with Insulin Resistance (IR) in Latent Autoimmune
   Diabetes Versus IR in Glutamic Acid Decarboxylase Antibody-negative
   Diabetes
SO ANNALS ACADEMY OF MEDICINE SINGAPORE
LA English
DT Article
DE GAD-negative diabetes; Insulin resistance; LADA
ID CHRONIC OXIDATIVE STRESS; BETA-CELL FUNCTION; GLUCOSE TOXICITY; GAD;
   AUTOANTIBODIES; PREVALENCE; ONSET; LADA; POSITIVITY; MECHANISM
AB Introduction: Insulin resistance in latent autoimmune diabetes in adults (LADA) patients is controversial. The aim of this study was to evaluate insulin resistance and its related factors (metabolic syndrome parameters) among subjects with LADA and glutamic acid decarboxylase antibodies (GADA) negative diabetes, as well as the impact of these factors on insulin resistance. Materials and Methods: GADA levels were investigated in 1140 diabetic patients aged between 30 and 70 years. Insulin resistance and metabolic syndrome parameters were assessed in LADA and GAD-negative diabetic patients by general linear model. In addition, the impact of metabolic syndrome factors on insulin resistance was assessed in LADA and glutamic acid decarboxylase (GAD)-negative diabetic patients. Results: LADA was diagnosed in 33 subjects from 1140 Malaysian diabetic patients (prevalence = 2.9%). The results showed that LADA patients had higher insulin resistance and high density lipoprotein cholesterol (HDLc) (P = 0.003 and 0.00017 respectively) and lower body mass index (BMI) (P = 0.007) compared to GAD-negative diabetic patients. The HDLc was associated with decreased insulin resistance in LADA patients (P=0.041), whereas HbA1c, triacylglycerides (TG) and waist were associated with increased insulin resistance in GAD-negative diabetic patients (P=3.6x10(-12), 1.01x10(-5) and 0.004 respectively). HbA1c was highly associated with decreasing beta-cell function in both LADA (P = 0.009) and GAD-negative diabetic subjects (P=2.2x10(-28)). Conclusion: Insulin resistance is significantly higher in LADA than GAD-negative diabetic Malaysian subjects.
C1 [Salem, Sameer D.; Muniandy, Sekaran] Univ Malaya, Fac Med, Dept Mol Med, Kuala Lumpur 50603, Malaysia.
   [Salem, Sameer D.; Saif-Ali, Riyadh; Al-Hamodi, Zaid] Sanaa Univ, Fac Med, Dept Biochem, Sanaa, Yemen.
   [Ismail, Ikram S.] Univ Malaya, Med Ctr, Dept Med, Kuala Lumpur 50603, Malaysia.
C3 Universiti Malaya; Universiti Malaya
RP Salem, SD (corresponding author), Univ Malaya, Fac Med, Dept Mol Med, Prot Lab, Kuala Lumpur 50603, Malaysia.
EM sameersalem@yahoo.com
RI Ismail, Ikram/A-6329-2009; Alhamodi, Zaid/D-1359-2010; Salem,
   Sameer/G-3517-2011; Saif-Ali, Riyadh/C-1536-2010; MUNIANDY,
   SEKARAN/B-5345-2010; Ismail, Ikram Shah/B-8651-2010
OI Saif-Ali, Riyadh/0000-0002-0246-3856; MUNIANDY,
   SEKARAN/0000-0003-1310-3634; Ismail, Ikram Shah/0000-0001-8796-1936;
   Salem, Sameer/0000-0002-8269-9382
FU University of Malaya [UM RG350/11HTM, PV029/2012A]
FX We thank all the participants of this research and all nursing and
   medical staff at UMMC for their dedication in this study. The authors
   wish to thank University of Malaya for supporting this study with the
   research grants, UM RG350/11HTM and PV029/2012A.
CR [Anonymous], 2012, ISRN PHARM, DOI DOI 10.5402/2012/580202
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NR 32
TC 6
Z9 6
U1 0
U2 1
PU ACAD MEDICINE SINGAPORE
PI REPUBLIC SINGAPORE
PA 142 NEIL RD, REPUBLIC SINGAPORE 088871, SINGAPORE
SN 0304-4602
J9 ANN ACAD MED SINGAP
JI Ann. Acad. Med. Singap.
PD FEB
PY 2014
VL 43
IS 2
BP 107
EP 112
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA AD7KK
UT WOS:000333442500007
PM 24652431
DA 2025-06-11
ER

PT J
AU Korita, I
   Bulo, A
   Langlois, M
   Blaton, V
AF Korita, Irena
   Bulo, Anyla
   Langlois, Michel
   Blaton, Victor
TI INFLAMMATION MARKERS IN PATIENTS WITH CARDIOVASCULAR DISEASE AND
   METABOLIC SYNDROME
SO JOURNAL OF MEDICAL BIOCHEMISTRY
LA English
DT Article
DE metabolic syndrome; inflammation; oxidative stress; stenosis; HDL
   lipoproteins
ID LOW-DENSITY-LIPOPROTEIN; ATHEROSCLEROSIS; CHOLESTEROL; CORONARY;
   GUIDELINES; PLASMA; LDL
AB Background: The clinical value and the interrelationship of HDL and the metabolic syndrome were studied using plasma levels of TNF-alpha, IL 6, IL 10, IL 8, IL 1 beta, IL 2R in patients with cardiovascular stenosis.
   Methods: On the basis of exclusion criteria, we recruited 198 male and female patients aged 45 to 75 years with CVD and 43 patients with MS. Patients were subdivided into %stenosis according to the CASS guidelines. Lipids were measured on an Olympus AU640 analyzer. Ox-LDL was measured by the immunosorbent assay and MDA by HPLC. Cytokines were analysed with DPC Immulite 1000. Statistical tests were performed using SPSS for Windows, 14.0 & Medcalc.
   Results: Ox-LDL and apoB were significantly higher in the MS(+) patient group (88.7 U/L) compared to the MS(-) group (77.5 U/L). Ox-LDL showed a positive correlation (P=0.001) with LDL-C, apoB and MDA. There was a higher concentration of HDL in the patient group MS(-), which was confirmed by a non-significant (P=0.849) change of apoA(I) from 1.267 g/L in the MS(+) to 1.275 g/L in the MS(-) group. A light significant increase of IL 10 (P=0.05) in MS(+) patients was observed, and the other analysed inflammation markers were mostly unchanged. MS has no direct association with the cytokine production.
   Conclusions: Ox-LDL and apoB were significantly higher in the MS(+) patient group. In a multiple regression analysis for ox-LDL, apoB (P=0.003) emerged as a strong predictor of the ox-LDL concentration, independent of age, gender. BMI and smoking.
C1 [Korita, Irena; Bulo, Anyla] Univ Hosp Ctr Mother Teresa, Dept Lab, Fac Med, Tirana, Albania.
   [Langlois, Michel; Blaton, Victor] AZ St Jan AV Dept Clin Chem Brugge, Brugge, Belgium.
   [Langlois, Michel; Blaton, Victor] Katholieke Univ Leuven, Louvain, Belgium.
C3 University Hospital Center Mother Teresa (QSUT); KU Leuven
RP Korita, I (corresponding author), Univ Hosp Ctr Mother Teresa, Dept Lab, RR Dibres 372, Tirana, Albania.
EM irenakorita@yahoo.it
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NR 27
TC 10
Z9 11
U1 0
U2 12
PU SCIENDO
PI WARSAW
PA DE GRUYTER POLAND SP Z O O, BOGUMILA ZUGA 32A STR, 01-811 WARSAW, POLAND
SN 1452-8258
EI 1452-8266
J9 J MED BIOCHEM
JI J. Med. Biochem.
PD JUL-SEP
PY 2013
VL 32
IS 3
BP 214
EP 219
DI 10.2478/jomb-2013-0016
PG 6
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 187EC
UT WOS:000322098700003
OA gold
DA 2025-06-11
ER

PT J
AU Ashraf, GM
   Chibber, S
   Mohammad
   Zaidi, SK
   Tabrez, S
   Ahmad, A
   Shakil, S
   Mushtaq, G
   Baeesa, SS
   Kamal, MA
AF Ashraf, Ghulam M.
   Chibber, Sandesh
   Mohammad
   Zaidi, Syed K.
   Tabrez, Shams
   Ahmad, Ausaf
   Shakil, Shazi
   Mushtaq, Gohar
   Baeesa, Saleh S.
   Kamal, Mohammad A.
TI Recent Updates on the Association Between Alzheimer's Disease and
   Vascular Dementia
SO MEDICINAL CHEMISTRY
LA English
DT Article
DE Alzheimer's disease; dementia; insulin resistance syndrome; nitric
   oxide; reactive oxygen species; therapy; vascular dementia
ID ENDOTHELIAL GROWTH-FACTOR; GOAT HEART GALECTIN-1; CELL-DEATH MECHANISMS;
   CEREBRAL-BLOOD-FLOW; NITRIC-OXIDE; APOLIPOPROTEIN-E; OXIDATIVE STRESS;
   AMYLOID-BETA; INSULIN-RESISTANCE; MOUSE MODEL
AB The two most common forms of dementia are Alzheimer's disease (AD) followed by vascular dementia (VaD), together accounting for a whopping 60-80% of total dementia cases worldwide. Even though these diseases are recognized as 'common', they still remain underdiagnosed. Recent research suggests that AD and VaD are closely intertwined. The symptoms of AD and VaD can be similar and the two conditions can occur simultaneously. A large number of patients diagnosed with AD have also been reported with VaD-caused brain damage. Moreover, both the diseases have been reported to have similar risk factors. The overlap between these diseases is important because the lifestyle changes and medications prescribed to curb one of these diseases may also help curb the other. In the present review, we present an inclusive outline of the parallelism between AD and VaD by exploring potential commonalities at the mechanistic and therapeutic levels.
C1 [Ashraf, Ghulam M.; Tabrez, Shams] King Abdulaziz Univ, King Fahd Med Res Ctr, POB 80216, Jeddah 21589, Saudi Arabia.
   [Chibber, Sandesh] Ahmedabad Univ, Inst Life Sci, Ahmadabad, Gujarat, India.
   [Mohammad] Indian Inst Technol, Dept Biosci & Bioenegineering BSBE, Mumbai, Maharashtra, India.
   [Zaidi, Syed K.] King Abdulaziz Univ, Ctr Excellence Genom Med Res, Jeddah 21413, Saudi Arabia.
   [Ahmad, Ausaf] Amity Univ Uttar Pradesh, Amity Inst Biotechnol, Lucknow, Uttar Pradesh, India.
   [Shakil, Shazi] King Abdulaziz Univ, KACST Technol Innovat Ctr Personalized Med, Jeddah 21413, Saudi Arabia.
   [Shakil, Shazi] King Abdulaziz Univ, Fac Appl Med Sci, Dept Med Lab Technol, Jeddah 21413, Saudi Arabia.
   [Mushtaq, Gohar] King Abdulaziz Univ, Coll Sci, Dept Biochem, Jeddah 21413, Saudi Arabia.
   [Baeesa, Saleh S.] King Abdulaziz Univ, Coll Med, Div Neurosurg, Jeddah 21413, Saudi Arabia.
   [Kamal, Mohammad A.] Enzymoics, 7 Peterlee Pl, Hebersham, NSW 2770, Australia.
C3 King Abdulaziz University; Ahmedabad University; Indian Institute of
   Technology System (IIT System); Indian Institute of Technology (IIT) -
   Bombay; King Abdulaziz University; King Abdulaziz University; King
   Abdulaziz University; King Abdulaziz University; King Abdulaziz
   University
RP Ashraf, GM (corresponding author), King Abdulaziz Univ, King Fahd Med Res Ctr, POB 80216, Jeddah 21589, Saudi Arabia.
EM gashraf@kau.edu.sa
RI Ahmad, Ausaf/AGU-5341-2022; Mushtaq, Gohar/GPP-1327-2022; Baeesa,
   Saleh/G-5519-2011; Chibber, Sandesh/ABD-5851-2021; Tabrez,
   Shams/H-9476-2012; Mushtaq, Gohar/G-5504-2015; Ashraf, Ghulam
   Md/H-9485-2012; Zaidi, Syed Kashif/A-6160-2013; Kamal, Mohammad
   Amjad/J-2918-2014; Shakil, Shazi/K-4132-2015
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NR 200
TC 43
Z9 44
U1 1
U2 21
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1573-4064
EI 1875-6638
J9 MED CHEM
JI Med. Chem.
PY 2016
VL 12
IS 3
BP 226
EP 237
DI 10.2174/1573406411666151030111820
PG 12
WC Chemistry, Medicinal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA DI7ML
UT WOS:000373684700005
PM 26527156
DA 2025-06-11
ER

PT J
AU Hart, R
   Doherty, DA
AF Hart, Roger
   Doherty, Dorota A.
TI The Potential Implications of a PCOS Diagnosis on a Woman's Long-Term
   Health Using Data Linkage
SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Article
ID POLYCYSTIC-OVARY-SYNDROME; IMPAIRED GLUCOSE-TOLERANCE;
   INSULIN-RESISTANCE; DIABETES-MELLITUS; CARDIOVASCULAR-DISEASE;
   ENDOMETRIAL CANCER; METABOLIC SYNDROME; WESTERN-AUSTRALIA; WOMEN; RISK
AB Context: The polycystic ovary syndrome (PCOS) is the commonest endocrine abnormality in women of reproductive age.
   Objective: To determine the rate of hospital admissions for women with PCOS in Western Australian population in comparison to women without PCOS.
   Design: A population-based retrospective cohort study using data linkage in a statewide hospital morbidity database system.
   Setting: All hospitals within Western Australia.
   Participants: A total of 2566 women with PCOS hospitalized from 1997-2011 and 25 660 randomly selected age-matched women without a PCOS diagnosis derived from the electoral roll.
   Main Outcome Measures: Hospitalizations by ICD-10-M diagnoses from 15 years were compared.
   Results: Hospitalizations were followed until a median age of 35.8 years (interquartile range, 31.0-39.9). PCOS was associated with more nonobstetric and non-injury-related hospital admissions (median, 5 vs 2; P < .001), a diagnosis of adult-onset diabetes (12.5 vs 3.8%), obesity (16.0 vs 3.7%), hypertensive disorder (3.8 vs 0.7%), ischemic heart disease (0.8 vs 0.2%), cerebrovascular disease (0.6 vs 0.2%), arterial and venous disease (0.5 vs 0.2% and 10.4 vs 5.6%, respectively), asthma (10.6 vs 4.5%), stress/anxiety (14.0 vs 5.9%), depression (9.8 vs 4.3%), licit/illicit drug-related admissions (8.8 vs 4.5%), self-harm (7.2 vs 2.9%), land transport accidents (5.2 vs 3.8%), and mortality (0.7 vs 0.4%) (all P < .001). Women with PCOS had a higher rate of admissions for menorrhagia (14.1 vs 3.6%), treatment of infertility (40.9 vs 4.6%), and miscarriage (11.1 vs 6.1%) and were more likely to require in vitro fertilization (17.2 vs 2.0%).
   Conclusion: PCOS has profound medical implications for the health of women, and health care resources should be directed accordingly.
C1 [Hart, Roger; Doherty, Dorota A.] Univ Western Australia, Sch Womens & Infants Hlth, Perth, WA 6008, Australia.
   [Hart, Roger] Bethesda Hosp, Fertil Specialists Western Australia, Perth, WA 6010, Australia.
   [Doherty, Dorota A.] King Edward Mem Hosp, Women & Infants Res Fdn, Perth, WA 6008, Australia.
C3 University of Western Australia; Women & Infants Research Foundation;
   King Edward Memorial Hospital; University of Western Australia
RP Hart, R (corresponding author), Univ Western Australia, Sch Womens & Infants Hlth, King Edward Mem Hosp, 374 Bagot Rd, Subiaco, WA 6008, Australia.
EM roger.hart@uwa.edu.au
OI Hart, Roger/0000-0002-6610-3040
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NR 50
TC 273
Z9 294
U1 1
U2 23
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0021-972X
EI 1945-7197
J9 J CLIN ENDOCR METAB
JI J. Clin. Endocrinol. Metab.
PD MAR
PY 2015
VL 100
IS 3
BP 911
EP 919
DI 10.1210/jc.2014-3886
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA CG5TR
UT WOS:000353358900039
PM 25532045
DA 2025-06-11
ER

PT J
AU Albu, A
   Para, I
   Porojan, M
AF Albu, Adriana
   Para, Ioana
   Porojan, Mihai
TI Uric Acid and Arterial Stiffness
SO THERAPEUTICS AND CLINICAL RISK MANAGEMENT
LA English
DT Review
DE uric acid; arterial stiffness; cardiovascular risk
ID XANTHINE-OXIDASE INHIBITION; MUSCLE-CELL-PROLIFERATION; CARDIAC-SURGERY
   PATIENTS; HIGH-DOSE ALLOPURINOL; PULSE-WAVE VELOCITY; VASCULAR INDEX
   CAVI; ALL-CAUSE MORTALITY; OXIDATIVE STRESS; BLOOD-PRESSURE; AORTIC
   STIFFNESS
AB Hyperuricemia is usually associated with hypertension, diabetes mellitus, metabolic syndrome and chronic kidney disease. Accumulating data from epidemiological studies indicate an association of increased uric acid (UA) with cardiovascular diseases. Possible pathogenic mechanisms include enhancement of oxidative stress and systemic inflammation caused by hyperuricemia. Arterial stiffness may be one of the possible pathways between hyperuricemia and cardiovascular disease, but a clear relationship between increased UA and vascular alterations has not been confirmed. The review summarizes the epidemiological studies investigating the relationship between UA and arterial stiffness and highlights the results of interventional studies evaluating arterial stiffness parameters in patients treated with UA-lowering drugs.
C1 [Albu, Adriana; Porojan, Mihai] Iuliu Hatieganu Univ Med & Pharm, Dept Internal Med 2, Cluj Napoca, Romania.
   [Para, Ioana] Iuliu Hatieganu Univ Med & Pharm, Dept Internal Med 4, 8 Babes St, Cluj Napoca 400012, Romania.
C3 Iuliu Hatieganu University of Medicine & Pharmacy; Iuliu Hatieganu
   University of Medicine & Pharmacy
RP Para, I (corresponding author), Iuliu Hatieganu Univ Med & Pharm, Dept Internal Med 4, 8 Babes St, Cluj Napoca 400012, Romania.
EM ioana.para@yahoo.com
RI albu, adriana/D-4480-2016
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NR 154
TC 38
Z9 40
U1 3
U2 17
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
EI 1178-203X
J9 THER CLIN RISK MANAG
JI Therap. Clin. Risk Manag.
PY 2020
VL 16
BP 39
EP 54
DI 10.2147/TCRM.S232033
PG 16
WC Health Care Sciences & Services
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Health Care Sciences & Services
GA KH6AG
UT WOS:000510731700001
PM 32095074
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Na, HJ
   Sung, MJ
   Park, JS
AF Na, Hyun-Jin
   Sung, Mi-Jeong
   Park, Joung-Sun
TI Age- and oxidative stress-induced centrosome amplification and renal
   stones in Drosophila Malpighian tubules
SO BIOLOGY OPEN
LA English
DT Article
DE Drosophila; Aging; Malpighian tubules; Centrosome amplification; Renal
   stone; Aging marker
ID METABOLIC SYNDROME; KIDNEY-STONE; STEM-CELLS; DEFICIENCY; COMPONENTS;
   METFORMIN
AB Renal diseases, including cancer, are rapidly increasing worldwide, driven by rising temperatures and changing diets, especially among younger people. Renal stones, a major risk for chronic renal disease, are increasingly common due to various health issues. Research on the underlying mechanisms, drug discovery, and the effects of aging and stress is limited. We used Drosophila, due to its similarity to the human renal system and ease of use, to identify cancer hallmarks and renal stone formation related to aging and oxidative stress. Our results indicate that centrosome amplification and stone formation increase with age and oxidative stress, and high sucrose feeding also heightens stone formation in the renal system. Our results show a close relationship between these diseases and aging, reactive oxygen species (ROS) stress, and chronic diseases. We suggest that the Drosophila renal model could be a powerful tool to study the relationship between age and age-related diseases and to discovering new agents for nephropathy.
C1 [Na, Hyun-Jin; Sung, Mi-Jeong] Korea Food Res Inst, Div Food Funct Res, Aging & Metab Res Grp, Wanju 55365, South Korea.
   [Park, Joung-Sun] Pusan Natl Univ, Inst Nanobio Convergence, Busan 46241, South Korea.
   [Park, Joung-Sun] Pusan Natl Univ, Dept Mol Biol, Busan 46241, South Korea.
C3 Korea Food Research Institute (KFRI); Pusan National University; Pusan
   National University
RP Park, JS (corresponding author), Pusan Natl Univ, Inst Nanobio Convergence, Busan 46241, South Korea.; Park, JS (corresponding author), Pusan Natl Univ, Dept Mol Biol, Busan 46241, South Korea.
EM dreamjs78@pusan.ac.kr
FU Main Research Program of the Korea Food Research Institute; Basic
   Science Research Program through the National Research Foundation of
   Korea (NRF) - Ministry of Education [RS-2023-00243729]; Pusan National
   University;  [E0210102]
FX This study was supported by the Main Research Program (E0210102) of the
   Korea Food Research Institute. This research was supported by the Basic
   Science Research Program through the National Research Foundation of
   Korea (NRF) , funded by the Ministry of Education (RS-2023-00243729) .
   Open Access funding provided by Pusan National University. Deposited in
   PMC for immediate release.
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NR 30
TC 1
Z9 1
U1 0
U2 0
PU COMPANY BIOLOGISTS LTD
PI CAMBRIDGE
PA BIDDER BUILDING, STATION RD, HISTON, CAMBRIDGE CB24 9LF, ENGLAND
SN 2046-6390
J9 BIOL OPEN
JI Biol. Open
PD DEC
PY 2024
VL 13
IS 12
AR bio061743
DI 10.1242/bio.061743
PG 6
WC Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics
GA R2A9Z
UT WOS:001389555700001
PM 39680672
OA gold
DA 2025-06-11
ER

PT J
AU Li, LL
   Guo, ZL
   Zhao, Y
   Liang, CJ
   Zheng, WX
   Tian, WX
   Chen, YL
   Cheng, Y
   Zhu, FW
   Xiang, XX
AF Li, Lanlan
   Guo, Zhiliang
   Zhao, Yi
   Liang, Chuanjie
   Zheng, Wenxiang
   Tian, Wenxiu
   Chen, Yalin
   Cheng, Yi
   Zhu, Fengwen
   Xiang, Xinxin
TI The impact of oxidative stress on abnormal lipid metabolism-mediated
   disease development
SO ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
LA English
DT Review
DE Oxidative stress; Abnormal lipid metabolism; Metabolic syndrome;
   Inflammation; Reactive oxygen species
ID FATTY LIVER-DISEASE; ATHEROSCLEROTIC CARDIOVASCULAR-DISEASE; PRIMARY
   PREVENTION; 2024 GUIDELINES; TAIWAN SOCIETY; OBESE MICE; HYPERTENSION;
   ACTIVATION; BIOMARKERS; CARDIOLOGY
AB Oxidative stress arises from an imbalance between cellular oxidation and anti-oxidation mechanisms, leading to various harmful effects on physiological health. These include inflammatory neutrophil infiltration, increased secretion of proteases, and increased production of oxidative intermediates, all of which significantly contribute to aging and the onset of multiple diseases. This review explores abnormal lipid metabolism, characterized by dysregulation in lipid synthesis, catabolism, digestion, absorption, and transport, with the potential to lead to lipid droplet accumulation or deficit across tissues, thus causing adverse health outcomes. Importantly, the intricate relationship between oxidative stress and inflammation plays a central role in exacerbating metabolic disorders, including diabetes, obesity, hypertension, non-alcoholic fatty liver disease, atherosclerosis, and lung fibrosis. This review seeks to compile and integrate recent research findings on the influence of oxidative stress on abnormal lipid metabolism pathology. A deeper understanding of this connection could reveal new perspectives for advancing the treatment and management of metabolic disorders.
C1 [Li, Lanlan; Liang, Chuanjie; Zheng, Wenxiang; Tian, Wenxiu; Chen, Yalin; Cheng, Yi; Zhu, Fengwen; Xiang, Xinxin] Zibo Cent Hosp, Ctr Translat Med, Zibo 255000, Shandong, Peoples R China.
   [Guo, Zhiliang] 80th Grp Army Hosp Chinese PLA, Weifang 261021, Shandong, Peoples R China.
   [Zhao, Yi] Shandongs First Med Univ, Shandong Prov Hosp, Jinan, Shandong, Peoples R China.
C3 Shandong First Medical University & Shandong Academy of Medical Sciences
RP Zhu, FW; Xiang, XX (corresponding author), Zibo Cent Hosp, Ctr Translat Med, Zibo 255000, Shandong, Peoples R China.
EM 389860168@qq.com; xiangxinxin@bjmu.edu.cn
FU Natural Science Foundation of Shandong Province [ZR2024MH344,
   ZR2020MC062]; National Natural Sciences Foundation of China [81600695];
   Key Research and Development Project of Shandong Province program
   [2019GSF108269]
FX This work was supported by the Natural Science Foundation of Shandong
   Province (No. ZR2024MH344 and ZR2020MC062) , National Natural Sciences
   Foundation of China (No.81600695) , the Key Research and Development
   Project of Shandong Province program (No. 2019GSF108269) .
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NR 108
TC 1
Z9 1
U1 10
U2 10
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0003-9861
EI 1096-0384
J9 ARCH BIOCHEM BIOPHYS
JI Arch. Biochem. Biophys.
PD APR
PY 2025
VL 766
AR 110348
DI 10.1016/j.abb.2025.110348
EA FEB 2025
PG 9
WC Biochemistry & Molecular Biology; Biophysics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics
GA Y2C5Z
UT WOS:001430272900001
PM 39961502
DA 2025-06-11
ER

PT J
AU Carro, N
   D'Adamo, P
   Lozada, M
AF Carro, N.
   D'Adamo, P.
   Lozada, M.
TI A School Intervention Helps Decrease Daily Stress While Enhancing Social
   Integration in Children
SO BEHAVIORAL MEDICINE
LA English
DT Article
DE Behavioral intervention; children stress; prevention; salivary cortisol;
   social integration
ID PROSOCIAL BEHAVIOR; METABOLIC SYNDROME; SALIVARY CORTISOL; PHYSICAL
   HEALTH; RESILIENCE; FRIENDSHIP; RESPONSES; SYMPTOMS; BRAIN
AB Stress coping is highly relevant during childhood. This study analyses how the participation in a behavioral intervention involving mindfulness-based practices and empathic collaboration activities impact on diurnal cortisol rhythm and social integration in children. In both experimental and waitlist groups, we evaluated before and after the intervention: daily stress, by sampling salivary cortisol at three measurement time-points, and social integration, assessed by a social preference index. Daily average cortisol (DAC) and the area under the curve (AUC) differed when comparing pre-post intervention values in both groups: in the experimental group these measures decreased while in the waitlist group DAC and AUC increased. At the end of the intervention, the experimental group showed an enhancement in the social preference index whereas this parameter diminished in the waitlist group. This kind of behavioral intervention seems to be effective at reducing daily stress and improving social integration in Primary School children.
C1 [Carro, N.; Lozada, M.] Natl Univ Comahue, INIBIOMA CONICET, San Carlos De Bariloche, Rio Negro, Argentina.
   [D'Adamo, P.] Natl Univ Comahue, IPEHCS, CONICET, Av de Los Pioneros 2350, RA-8400 San Carlos De Bariloche, Rio Negro, Argentina.
C3 Universidad Nacional del Comahue; Consejo Nacional de Investigaciones
   Cientificas y Tecnicas (CONICET); Consejo Nacional de Investigaciones
   Cientificas y Tecnicas (CONICET); Universidad Nacional del Comahue
RP D'Adamo, P (corresponding author), Natl Univ Comahue, IPEHCS, CONICET, Av de Los Pioneros 2350, RA-8400 San Carlos De Bariloche, Rio Negro, Argentina.
EM paodadamo@gmail.com
FU National University of Comahue; National Council of Scientific and
   Technological Research of Argentina (CONICET)
FX This work was supported in part by the National University of Comahue
   and National Council of Scientific and Technological Research of
   Argentina (CONICET).
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NR 50
TC 7
Z9 7
U1 1
U2 16
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 0896-4289
EI 1940-4026
J9 BEHAV MED
JI Behav. Med.
PD JUL 3
PY 2021
VL 47
IS 3
BP 251
EP 258
DI 10.1080/08964289.2020.1738319
EA MAR 2020
PG 8
WC Behavioral Sciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Behavioral Sciences; Psychiatry
GA TK9LM
UT WOS:000526498600001
PM 32275198
DA 2025-06-11
ER

PT J
AU Welch, G
   Wesolowski, C
   Zagarins, S
   Kuhn, J
   Romanelli, J
   Garb, J
   Allen, N
AF Welch, Garry
   Wesolowski, Cheryl
   Zagarins, Sofija
   Kuhn, Jay
   Romanelli, John
   Garb, Jane
   Allen, Nancy
TI Evaluation of Clinical Outcomes for Gastric Bypass Surgery: Results from
   a Comprehensive Follow-up Study
SO OBESITY SURGERY
LA English
DT Article
DE RYGB; Weight loss; %EWL; Bariatric surgery; Metabolic syndrome;
   Psychosocial adjustment; Self-management behaviors
ID PREDICTS WEIGHT-LOSS; PHYSICAL-ACTIVITY; BARIATRIC SURGERY;
   MORBID-OBESITY; SUCCESS
AB Background Laparoscopic gastric bypass (LGB) surgery markedly increases percent excess weight loss (%EWL) and obesity-related co-morbidities. However, poor study quality and minimal exploration of clinical, behavioral, and psychosocial mechanisms of weight loss have characterized research to date.
   Methods We conducted a comprehensive assessment of n=100 LGB patients surveyed 2-3 years following surgery using standardized measures.
   Results Mean %EWL at follow-up was 59.1+/-17.2%. This high level of weight loss was associated with a low rate of metabolic syndrome (10.6%), although medications were commonly used to achieve control. Mean adherence to daily vitamin and mineral supplements important to the management of LGB was only 57.6%, and suboptimal blood chemistry levels were found for ferritin (32% of patients), hematocrit (27%), thiamine (25%), and vitamin D (19%). Aerobic exercise level (R-2=0.08) and pre-surgical weight (R-2=0.04) were significantly associated with %EWL, but recommended eating style, fluid intake, clinic follow-up, and support group attendance were not. Psychosocial adjustment results showed an absence of symptomatic depression (0%), common use of antidepressant medications (32.0%), low emotional distress related to the post-surgical lifestyle (19.8+/-14.0; scale range 0-100), a high level of perceived benefit from weight loss in terms of functioning and emotional well-being (82.7+/-17.9; scale range 0-100), and a change in marital status for 26% of patients.
   Conclusions At 2-3 years following LGB surgery aerobic exercise, but not diet, fluid intake, or attendance at clinic visits or support groups, is associated with %EWL. Depression is symptomatically controlled by medications, lifestyle related distress is low, and marital status is significantly impacted.
C1 [Welch, Garry; Wesolowski, Cheryl; Kuhn, Jay; Romanelli, John] Baystate Med Ctr, Weight Loss Surg Program, Springfield, MA 01199 USA.
   [Garb, Jane] Baystate Med Ctr, Dept Acad Affairs, Springfield, MA 01199 USA.
   [Allen, Nancy] Baystate Med Ctr, Dept Endocrinol & Diabet, Springfield, MA 01199 USA.
C3 Baystate Medical Center; Baystate Medical Center; Baystate Medical
   Center
RP Welch, G (corresponding author), Baystate Med Ctr, Weight Loss Surg Program, 140 High St,Room 2104, Springfield, MA 01199 USA.
EM Garry.Welch@BHS.Org
RI Romanelli, John/AAX-1946-2020
OI Allen, Nancy A./0000-0001-7358-2265
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   MACARTHUR INITIATIVE
NR 42
TC 40
Z9 45
U1 0
U2 8
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0960-8923
EI 1708-0428
J9 OBES SURG
JI Obes. Surg.
PD JAN
PY 2011
VL 21
IS 1
BP 18
EP 28
DI 10.1007/s11695-009-0069-3
PG 11
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 709FP
UT WOS:000286423600004
PM 20087678
DA 2025-06-11
ER

PT J
AU Sheng, W
   Ji, G
   Zhang, L
AF Sheng, Wei
   Ji, Guang
   Zhang, Li
TI Management of non-alcoholic fatty liver disease patients with sleep
   apnea syndrome
SO WORLD JOURNAL OF GASTROENTEROLOGY
LA English
DT Review
DE Nonalcoholic fatty liver disease; Sleep apnea syndrome; Obesity;
   Obstructive sleep apnea hypopnea syndrome; Continuous positive airway
   pressure; Management
ID POSITIVE AIRWAY PRESSURE; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   OXIDATIVE STRESS; 3.0 MG; THERAPY; STEATOHEPATITIS; ASSOCIATION; ACIDS;
   LIRAGLUTIDE
AB Nonalcoholic fatty liver disease (NAFLD) is strongly associated with sleep apnea syndrome (SAS). Many NAFLD patients have SAS, and obstructive sleep apnea hypopnea syndrome is also considered to be an independent risk factor for NAFLD, as it contributes to the progression of NAFLD via oxidative stress, lipid peroxidation, inflammation, and insulin resistance. This review aims to provide some recommendations for the management of NAFLD patients with SAS, including diet, exercise, weight loss, and continuous positive airway pressure. This review also highlights the importance of effective strategies in NAFLD prevention and treatment.
C1 [Sheng, Wei; Ji, Guang; Zhang, Li] Shanghai Univ Tradit Chinese Med, Longhua Hosp, Inst Digest Dis, Shanghai 200032, Peoples R China.
   [Zhang, Li] Shanghai Univ Tradit Chinese Med, Longhua Hosp, Inst Digest Dis, 725 South Wanping Rd, Shanghai 200032, Peoples R China.
C3 Shanghai University of Traditional Chinese Medicine; Shanghai University
   of Traditional Chinese Medicine
RP Zhang, L (corresponding author), Shanghai Univ Tradit Chinese Med, Longhua Hosp, Inst Digest Dis, 725 South Wanping Rd, Shanghai 200032, Peoples R China.
EM zhangli.hl@163.com
FU Project of Shanghai Hospital Development Center [SHDC2020CR4044]
FX Supported by the Project of Shanghai Hospital Development Center, No.
   SHDC2020CR4044.
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   Zheng JL, 2022, CLIN NUTR, V41, P2295, DOI 10.1016/j.clnu.2022.08.018
NR 82
TC 2
Z9 2
U1 2
U2 12
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 7041 Koll Center Parkway, Suite 160, PLEASANTON, CA, UNITED STATES
SN 1007-9327
EI 2219-2840
J9 WORLD J GASTROENTERO
JI World J. Gastroenterol.
PD NOV 21
PY 2022
VL 28
IS 43
BP 6099
EP 6108
DI 10.3748/wjg.v28.i43.6099
PG 10
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 6T4HF
UT WOS:000893638200003
PM 36483151
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Blum, A
AF Blum, A.
TI Gender differences in vascular aging and in coronary artery disease
   pathophysiology
SO QJM-AN INTERNATIONAL JOURNAL OF MEDICINE
LA English
DT Review
ID IMPROVES ENDOTHELIAL FUNCTION; RISK-FACTORS; CARDIOVASCULAR-DISEASE;
   MYOCARDIAL-INFARCTION; MENOPAUSAL TRANSITION; SEDENTARY OCCUPATIONS;
   METABOLIC SYNDROME; OXIDATIVE STRESS; WOMENS HEALTH; NITRIC-OXIDE
AB Women have a clinical advantage over men in relation to atherosclerotic cardiovascular disease (CVD) (morbidity and mortality). This advantage disappears once women become older, and in their seventh decade, the risk to develop CVD equals men at that age. There have been several theories about this gender difference that were related to hormones, and the different morphology and physiology that characterize the cardiovascular system in women. In this review, the different mechanisms will be reviewed and discussed.
C1 [Blum, A.] Bar Ilan Univ, Azrieli Fac Med, Tzafon Med Ctr, Dept Med, IL-15208 Lower Galilee, Israel.
C3 Bar Ilan University
RP Blum, A (corresponding author), Bar Ilan Univ, Azrieli Fac Med, Tzafon Med Ctr, Dept Med, IL-15208 Lower Galilee, Israel.
EM ablum@tzmc.health.gov.il
RI Blum, Arnon/IWD-5144-2023
OI Blum, Arnon/0000-0003-3863-4036
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NR 56
TC 5
Z9 5
U1 0
U2 0
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1460-2725
EI 1460-2393
J9 QJM-INT J MED
JI QJM-An Int. J. Med.
PD OCT 6
PY 2023
VL 116
IS 9
BP 745
EP 749
DI 10.1093/qjmed/hcad027
EA FEB 2023
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA U1LN0
UT WOS:000945596300001
PM 36821436
DA 2025-06-11
ER

PT J
AU Akbay, E
   Ulusu, NN
   Törüner, F
   Ayvaz, G
   Taneri, F
   Aktürk, M
   Arslan, M
   Karasu, Ç
AF Akbay, E
   Ulusu, NN
   Törüner, F
   Ayvaz, G
   Taneri, F
   Aktürk, M
   Arslan, M
   Karasu, Ç
TI Effects of rosiglitazone treatment on the pentose phosphate pathway and
   glutathione-dependent enzymes in liver and kidney of rats fed a high-fat
   diet
SO CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL
LA English
DT Article
DE rosiglitazone; pentose phosphate pathway; glutathione-dependent
   metabolism; metabolic syndrome; high-fat diet; rat; obesity
ID PEROXISOME PROLIFERATORS; ANTIOXIDANT ENZYMES; LIPID-PEROXIDATION;
   OXIDATIVE STRESS; RECEPTOR-GAMMA; TROGLITAZONE; PURIFICATION;
   HEPATOCYTES; MECHANISMS; LEPTIN
AB Background: Animals fed high-fat diets have been shown to develop hyperglycemia, insulin resistance, hyperlipidemia, and moderate obesity, which resemble the human metabolic syndrome. Obesity, the metabolic syndrome, and some thiazolidinediones, which act as insulin sensitizers, may increase oxidative stress, and/or influence the levels of cellular reducing equivalents and homeostasis.
   Objective: This study investigated the effects of a high-fat diet, rosiglitazone, or a high-fat diet plus rosiglitazone on metabolic syndrome parameters and crucial liver and kidney enzyme activities in rats.
   Methods: Male Wistar rats were assigned to 4 groups (n = 6 per group): (1) the fat (F) group was fed a rodent diet comprising 45 kcal% fat, (2) the rosiglitazone (R) group was fed a standard rat chow comprising 4.97 kcal% fat plus rosiglitazone (3 mg/kg(.)d), (3) the fat + rosiglitazone (FR) group was fed a rodent diet comprising 45 kcal% fat (as lard, product D12451) plus rosiglitazone (3 mg/kg(.)d), and (4) the control (C) group was fed a standard rat chow comprising 4.97 kcal% fat. Animals were housed for 4 weeks, at which time the liver and kidney were isolated for spectrophotometric determination of enzyme activities. Body weight was measured before treatment (baseline) and then weekly throughout the study. Adiposity was measured at the end of the 4 weeks.
   Results: The activities of glucose-6-phosphate dehydrogenase (GPD), 6-phosphogluconate dehydrogenase (6-PGD), glutathione reductase (GR), and glutathione-S-transferase (GST) were significantly reduced in the livers of groups F, R, and FR compared with group C (all P < 0.05). Kidney G6PD, 6-PGD,and GR were found to be significantly lower in group R compared with the other groups (all P < 0.05). Kidney GST was similar in all groups. Plasma glucose, triglyceride, and insulin concentrations were significantly higher than in group F versus the other groups (all P < 0.05). Adiposity was increased in groups F and FR compared with groups C and R (all P < 0.05). Serum cholesterol concentrations were similar in all groups.
   Conclusions: In this study, high-fat diet in rats decreased the enzyme activities responsible for pentose phosphate pathway and glutathione-dependent metabolism in liver but not in kidney. Similarly, these enzyme activities were inhibited with rosiglitazone treatment alone in both organs. (Curr Ther Res Clin Exp. 2004;65:79-89) Copyright (C) 2004 Excerpta Medica, Inc.
C1 Gazi Univ, Fac Med, Dept Med Pharmacol, TR-06510 Ankara, Turkey.
   Gazi Univ, Fac Med, Dept Endocrinol Metab, TR-06510 Ankara, Turkey.
   Gazi Univ, Fac Med, Dept Surg, TR-06510 Ankara, Turkey.
   Mersin Univ, Fac Med, Dept Endocrinol, Mersin, Turkey.
   Hacettepe Univ, Fac Med, Dept Biochem, TR-06100 Ankara, Turkey.
C3 Gazi University; Gazi University; Gazi University; Mersin University;
   Hacettepe University
RP Karasu, Ç (corresponding author), Gazi Univ, Fac Med, Dept Med Pharmacol, TR-06510 Ankara, Turkey.
EM karasu@gazi.edu.tr
RI Karasu, Çimen/JVZ-4637-2024; Toruner, Fusun/ABC-4701-2021; nn,
   ulusu/AAF-1827-2019
OI Toruner, Fusun/0000-0002-6168-937X; Ulusu, Nuray
   Nuriye/0000-0002-3173-1389; Karasu, Cimen/0000-0002-0954-8465
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NR 35
TC 13
Z9 14
U1 0
U2 9
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0011-393X
J9 CURR THER RES CLIN E
JI Curr. Ther. Res.-Clin. Exp.
PD JAN-FEB
PY 2004
VL 65
IS 1
BP 79
EP 89
DI 10.1016/S0011-393X(04)90007-0
PG 11
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA 805TC
UT WOS:000220387600008
PM 24936106
OA Green Accepted, Green Published
DA 2025-06-11
ER

PT J
AU Ginström, L
   Kaseva, K
   Peltonen, JE
   Saarikallio, S
   Tervaniemi, M
AF Ginstrom, Laura
   Kaseva, Kaisa
   Peltonen, Juha E.
   Saarikallio, Suvi
   Tervaniemi, Mari
TI Using music as a mood regulator in everyday life is associated with
   unfavourable health and fitness outcomes in overweight adults
SO PLOS ONE
LA English
DT Article
ID ACTIVITY QUESTIONNAIRE IPAQ; TIME PHYSICAL-ACTIVITY; ALVEOLAR
   GAS-EXCHANGE; BODY-MASS INDEX; METABOLIC SYNDROME; CARDIORESPIRATORY
   FITNESS; TISSUE DEOXYGENATION; EMOTION REGULATION; EXERCISE DOMAIN;
   SELF-REGULATION
AB Individual traits and habits have shown to be associated with health and health behaviour. One such habit is how individuals use music. This study aimed to examine if using music as a mood regulator is related to risk factors of lifestyle diseases. Participants who joined the present Motivation Makes the Move! lifestyle intervention were overweight and sedentary adults (n = 76, ages 19-40). They answered questionnaires about physical activity and use of music. They also underwent a cardiopulmonary exercise test and their body composition was assessed. Additionally, the analyses' robustness was tested through controlling for physical, sociodemographic and psychological health related factors. We observed that despite the participants' self-reported commitment to regular physical activity, their fitness level was poor. Using music as a mood regulator was associated with lower cardiorespiratory fitness. Use of music was also positively linked to body fat percentage, although this finding did not remain significant after adjusting for age, educational level and experienced health. We urge future research to address the relationship between music use and risk factors of lifestyle diseases in a population sample.
C1 [Ginstrom, Laura; Tervaniemi, Mari] Univ Helsinki, Fac Educ Sci, Ctr Excellence Mus Mind Body & Brain, Helsinki, Finland.
   [Ginstrom, Laura; Kaseva, Kaisa; Peltonen, Juha E.] Univ Helsinki, Fac Med, Sports & Exercise Med, Helsinki, Finland.
   [Ginstrom, Laura; Kaseva, Kaisa; Peltonen, Juha E.] Fdn Sports & Exercise Med, Helsinki Sports & Exercise Med Clin HULA, Helsinki, Finland.
   [Kaseva, Kaisa] Univ Helsinki, Fac Educ Sci, Dept Educ, Helsinki, Finland.
   [Saarikallio, Suvi] Univ Jyvaskyla, Ctr Excellence Mus Mind Body & Brain, Helsinki, Finland.
   [Tervaniemi, Mari] Univ Helsinki, Fac Med, Dept Psychol, Cognit Brain Res Unit, Helsinki, Finland.
C3 University of Helsinki; University of Helsinki; University of Helsinki;
   University of Jyvaskyla; University of Helsinki
RP Tervaniemi, M (corresponding author), Univ Helsinki, Fac Educ Sci, Ctr Excellence Mus Mind Body & Brain, Helsinki, Finland.; Tervaniemi, M (corresponding author), Univ Helsinki, Fac Med, Dept Psychol, Cognit Brain Res Unit, Helsinki, Finland.
EM mari.tervaniemi@helsinki.fi
OI Kaseva, Kaisa/0000-0002-3712-7756; Saarikallio,
   Suvi/0000-0002-4647-8048; Tervaniemi, Mari/0000-0002-9651-2929
FU Business Finland
FX We gratefully acknowledge Dr. Daniela Eklund, Sanni Malander, and Enni
   Heikura for their contribution in data acquisition and coding and Dr.
   Kaisamari Kostilainen for her expertise in planning the study.
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NR 72
TC 0
Z9 0
U1 0
U2 0
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD FEB 27
PY 2025
VL 20
IS 2
AR e0317607
DI 10.1371/journal.pone.0317607
PG 16
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA Y9S6H
UT WOS:001435433800011
PM 40014605
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Li, YR
   Zhu, H
   Danelisen, I
AF Li, Y. Robert
   Zhu, Hong
   Danelisen, Igor
TI Role of Peroxiredoxins in Protecting Against Cardiovascular and Related
   Disorders
SO CARDIOVASCULAR TOXICOLOGY
LA English
DT Article
DE Cardiovascular disease; Diabetes; Inflammation; Metabolic syndrome;
   Oxidative stress; Peroxiredoxin; Sepsis
ID PHOSPHOLIPASE A(2) ACTIVITY; OXIDATIVE STRESS; 1-CYS PEROXIREDOXIN;
   OVEREXPRESSION; ATHEROSCLEROSIS; DEFICIENCY; ACTIVATION; ENZYME; CELLS;
   H2O2
AB Peroxiredoxin (Prx) refers to a family of thiol-dependent peroxidases that decompose hydrogen peroxide, lipid hydroperoxides, as well as peroxynitrite, and protect against oxidative and inflammatory stress. There are six mammalian Prx isozymes (Prx1-6), classified as typical 2-Cys, atypical 2-Cys, or 1-Cys Prxs based on the mechanism and the number of cysteine residues involved during catalysis. In addition to their well-established peroxide-scavenging activity, some Prxs also participate in the regulation of various cell signaling pathways. Extensive animal studies employing primarily gene knockout models provide substantial evidence supporting a critical protective role of Prxs in various disease processes involving oxidative and inflammatory stress. This review surveys recent research findings, published primarily in influential journals, on the involvement of various Prx isozymes in protecting against cardiovascular injury and related disorders, including diabetes, metabolic syndromes, and sepsis, whose pathophysiology all intimately involves oxidative stress and inflammation.
C1 [Li, Y. Robert] Campbell Univ, Jerry Wallace Sch Osteopath Med, Dept Pharmacol, Buies Creek, NC 27506 USA.
   [Zhu, Hong] Campbell Univ, Sch Osteopath Med, Dept Physiol & Pathophysiol, Buies Creek, NC 27506 USA.
   [Danelisen, Igor] Tufts Univ, Sch Med, Dept Med Educ, Boston, MA 02111 USA.
C3 Campbell University; Campbell University; Tufts University
RP Li, YR (corresponding author), Campbell Univ, Jerry Wallace Sch Osteopath Med, Dept Pharmacol, Buies Creek, NC 27506 USA.
EM yli@campbell.edu
OI Reis, AlessanRSS/0000-0001-8486-7469
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NR 47
TC 15
Z9 15
U1 1
U2 4
PU HUMANA PRESS INC
PI TOTOWA
PA 999 RIVERVIEW DRIVE SUITE 208, TOTOWA, NJ 07512 USA
SN 1530-7905
EI 1559-0259
J9 CARDIOVASC TOXICOL
JI Cardiovasc. Toxicol.
PD OCT
PY 2020
VL 20
IS 5
BP 448
EP 453
DI 10.1007/s12012-020-09588-0
EA JUL 2020
PG 6
WC Cardiac & Cardiovascular Systems; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Toxicology
GA NL6FY
UT WOS:000545933800001
PM 32632849
DA 2025-06-11
ER

PT J
AU Stephen, DS
   Abraham, A
AF Stephen, DSouza Serena
   Abraham, Asha
TI High-fat simple carbohydrate (HFSC) diet impairs hypothalamic and corpus
   striatal serotonergic metabolic pathway in metabolic syndrome (MetS)
   induced C57BL/6J mice
SO NUTRITIONAL NEUROSCIENCE
LA English
DT Article
DE Serotonin; 5-HTP; 5-HIAA; High-Performance Liquid Chromatography;
   High-Fat Simple Carbohydrate Diet; C57BL/6J Mice; Metabolic Syndrome
ID INSULIN-RESISTANCE; DIABETES-MELLITUS; ACID; RESPONSIVITY; RECEPTORS;
   DISORDER; RELEASE; WOMEN
AB Objectives: To study the effect of specially formulated high-fat simple carbohydrate diet (HFSC) on the serotonin metabolic pathway in male C57BL/6J mice. Methods: Previous studies from our laboratory have shown that specially formulated HFSC induces metabolic syndrome in C57BL/6J mice. In the present investigation, 5-hydroxytryptophan, serotonin and 5-hydroxyindoleacetic acid were analyzed in two brain regions (hypothalamus, corpus striatum), urine and plasma of HFSC-fed mice on a monthly basis up to 5 months using high-performance liquid chromatography fitted with electrochemical detector. The data were analyzed using Graph pad Prism v7.3 by two-way ANOVA and post hoc Tukey's test (to assess the effect of time on the serotonergic metabolic pathway). Results: HFSC feed was observed to lower the hypothalamic serotonergic tone as compared to the age-matched control-fed C57BL/6J mice. Although the hypothalamic serotonergic tone was unaltered over time due to consumption of diet per se, hypothalamic 5-HTP levels were observed to be lower on consumption of HFSC feed over duration of 5 months as compared to 1st month of consumption of HFSC feed. The striatal 5-HTP levels were lowered in the HFSC-fed mice after 4 months of feeding as compared to the age-matched control-fed mice. The striatal 5-HTP levels were also lower in both control and HFSC-fed mice due to consumption of the respective diet over a duration of 5 months. Increased plasma 5-HTP levels were observed due to consumption of HFSC feed over duration of 5 months in the HFSC-fed group. However, higher breakdown of serotonin was observed in both the plasma and urine of HFSC-fed C57BL/6J mice as per the turnover studies. Discussion: The central and peripheral serotonergic pathway is affected differentially by both the type of diet consumed and the duration for which the diet is consumed. The hypothalamic, striatal and plasma serotonergic pathway were altered both by the type of feed consumed and the duration of feeding. The urine serotonergic pathway was affected by mainly the duration for which a particular diet was consumed. These findings may have implications in the feeding behavior, cognitive decline and depression associated with metabolic syndrome patients.
C1 [Stephen, DSouza Serena; Abraham, Asha] St Aloysius Autonomous Coll, Dept Postgrad Studies & Res Biotechnol, Father George Albuquerque Pai Cell & Mol Biol Lab, Mangaluru 575003, Karnataka, India.
   [Stephen, DSouza Serena] Indian Inst Technol, Dept Chem Engn, Prot Engn Lab, 125 B, Bombay 400076, Maharashtra, India.
C3 Indian Institute of Technology System (IIT System); Indian Institute of
   Technology (IIT) - Bombay
RP Abraham, A (corresponding author), St Aloysius Autonomous Coll, Dept Postgrad Studies & Res Biotechnol, Father George Albuquerque Pai Cell & Mol Biol Lab, Mangaluru 575003, Karnataka, India.
EM abraham.asha@gmail.com
RI Abraham, Asha/ABD-8580-2020
OI Abraham, Asha/0000-0002-0201-5551
FU Council of Scientific and Industrial Research [08/439(0004)/2010-EMR-1];
   University Grants Commission [39-251/2010 (SR)]
FX This work was supported by Council of Scientific and Industrial Research
   (grant number 08/439(0004)/2010-EMR-1) and University Grants Commission
   (grant number F. No. 39-251/2010 (SR)).
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NR 45
TC 4
Z9 4
U1 0
U2 11
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1028-415X
EI 1476-8305
J9 NUTR NEUROSCI
JI Nutr. Neurosci.
PD JAN 2
PY 2019
VL 22
IS 1
BP 51
EP 62
DI 10.1080/1028415X.2017.1354511
PG 12
WC Neurosciences; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Nutrition & Dietetics
GA HC5DK
UT WOS:000451823500005
PM 28745143
DA 2025-06-11
ER

PT J
AU Park, HJ
   Bruno, RS
AF Park, Hea Jin
   Bruno, Richard S.
TI Hepatoprotective activities of green tea in nonalcoholic fatty liver
   disease
SO AGRO FOOD INDUSTRY HI-TECH
LA English
DT Article
DE green tea; nonalcoholic fatty liver disease; catechins; oxidative stress
ID METABOLIC SYNDROME; EPIGALLOCATECHIN GALLATE; CATECHIN-POLYPHENOLS;
   INSULIN-RESISTANCE; HEPATIC STEATOSIS; ANTIOXIDANT; EXTRACT; EXPRESSION;
   (-)-EPIGALLOCATECHIN-3-GALLATE; CONSUMPTION
AB Nonalcoholic fatty liver disease (NAFLD) is a constellation of asymptomatic liver diseases that increase liver-related morbidity and modality risk. The development of NAFLD is attributed to obesity and insulin resistance that cause excess hepatic lipid accumulation and increase the vulnerability of the liver to hepatotoxic insults such as oxidative stress and inflammatory responses. Accumulating evidence demonstrates that green tea, likely through its catechins, exerts hypolipidemic, antioxidant and anti-inflammatory activities, making it an ideal candidate functional food for preventing and/or managing NAFLD. Thus, this review will describe the multi-faceted hepatoprotective activities of green tea on the pathogenic events leading to NAFLD.
C1 [Park, Hea Jin; Bruno, Richard S.] Univ Connecticut, Dept Nutr Sci, Storrs, CT 06269 USA.
C3 University of Connecticut
RP Bruno, RS (corresponding author), Univ Connecticut, Dept Nutr Sci, Storrs, CT 06269 USA.
RI Bruno, Richard/K-1930-2012
OI Bruno, Richard/0000-0002-6772-2038
FU USDA National Institute for Food and Agriculture [2007-02303];
   USDA-HATCH [CONS00802]
FX This project was supported by grants to RSB from the National Research
   Initiative Grant 2007-02303 from the USDA National Institute for Food
   and Agriculture as well as the USDA-HATCH (CONS00802) program. We also
   wish to thank Kevin Noonan for assistance with the artwork.
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NR 30
TC 5
Z9 6
U1 0
U2 5
PU TEKNOSCIENZE PUBL
PI MILANO
PA VIALE BRIANZA 22, 20127 MILANO, ITALY
SN 1722-6996
EI 2035-4606
J9 AGRO FOOD IND HI TEC
JI Agro Food Ind. Hi-Tech
PD JAN-FEB
PY 2010
VL 21
IS 1
BP 37
EP 40
PG 4
WC Biotechnology & Applied Microbiology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Food Science & Technology
GA 570DN
UT WOS:000275652000010
DA 2025-06-11
ER

PT J
AU Padmanabhan, V
   Cardoso, RC
   Puttabyatappa, M
AF Padmanabhan, Vasantha
   Cardoso, Rodolfo C.
   Puttabyatappa, Muraly
TI Developmental Programming, a Pathway to Disease
SO ENDOCRINOLOGY
LA English
DT Review
ID POLYCYSTIC-OVARY-SYNDROME; HIGH-FAT DIET; INTRAUTERINE
   GROWTH-RETARDATION; BODY-MASS INDEX; MATERNAL OBESITY; PRENATAL STRESS;
   POLYCHLORINATED-BIPHENYLS; FETAL ORIGINS; LIFE-STYLE; METABOLIC SYNDROME
AB Accumulating evidence suggests that insults occurring during the perinatal period alter the developmental trajectory of the fetus/offspring leading to long-term detrimental outcomes that often culminate in adult pathologies. These perinatal insults include maternal/fetal disease states, nutritional deficits/excess, stress, lifestyle choices, exposure to environmental chemicals, and medical interventions. In addition to reviewing the various insults that contribute to developmental programming and the benefits of animal models in addressing underlying mechanisms, this review focuses on the commonalities in disease outcomes stemming from various insults, the convergence of mechanistic pathways via which various insults can lead to common outcomes, and identifies the knowledge gaps in the field and future directions.
C1 [Padmanabhan, Vasantha; Cardoso, Rodolfo C.; Puttabyatappa, Muraly] Univ Michigan, Dept Pediat, 1150 West Med Ctr Dr,7510 MSRB 1, Ann Arbor, MI 48109 USA.
C3 University of Michigan System; University of Michigan
RP Padmanabhan, V (corresponding author), Univ Michigan, Dept Pediat, 1150 West Med Ctr Dr,7510 MSRB 1, Ann Arbor, MI 48109 USA.
EM vasantha@umich.edu
RI Puttabyatappa, Muraly/K-2598-2015; Padmanabhan, Vasantha/C-8558-2017
OI Cardoso, Rodolfo/0000-0002-2466-5205; Padmanabhan,
   Vasantha/0000-0002-8443-7212
FU National Institutes of Health [P01 HD44232]; National Institute of
   Diabetes and Digestive and Kidney Diseases [P30DK020572] Funding Source:
   NIH RePORTER
FX This work was supported by National Institutes of Health Grant P01
   HD44232.
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NR 200
TC 171
Z9 180
U1 0
U2 25
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0013-7227
EI 1945-7170
J9 ENDOCRINOLOGY
JI Endocrinology
PD APR
PY 2016
VL 157
IS 4
BP 1328
EP 1340
DI 10.1210/en.2016-1003
PG 13
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism
GA DK0CK
UT WOS:000374579800004
PM 26859334
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Palkina, KA
   Ipatova, DA
   Shakhova, ES
   Balakireva, AV
   Markina, NM
AF Palkina, Kseniia A.
   Ipatova, Daria A.
   Shakhova, Ekaterina S.
   Balakireva, Anastasia V.
   Markina, Nadezhda M.
TI Therapeutic Potential of Hispidin-Fungal and Plant Polyketide
SO JOURNAL OF FUNGI
LA English
DT Review
DE hispidin; polyketides; antioxidant; therapeutic potential
ID PHELLINUS-LINTEUS PROTECTS; ADVANCED GLYCATION ENDPRODUCTS; PHOSPHATASE
   1B INHIBITORS; OXIDATIVE STRESS; MITOCHONDRIAL DYSFUNCTION; MEDICINAL
   FUNGI; ANTIOXIDANT HISPIDIN; SIGNAL-TRANSDUCTION; MYCELIAL CULTURES;
   SKELETAL-MUSCLE
AB There is a large number of bioactive polyketides well-known for their anticancer, antibiotic, cholesterol-lowering, and other therapeutic functions, and hispidin is among them. It is a highly abundant secondary plant and fungal metabolite, which is investigated in research devoted to cancer, metabolic syndrome, cardiovascular, neurodegenerative, and viral diseases. This review summarizes over 20 years of hispidin studies of its antioxidant, anti-inflammatory, anti-apoptotic, antiviral, and anti-cancer cell activity.
C1 [Palkina, Kseniia A.; Ipatova, Daria A.; Shakhova, Ekaterina S.; Balakireva, Anastasia V.; Markina, Nadezhda M.] Russian Acad Sci, Dept Biomol Chem, Shemyakin Ovchinnikov Inst Bioorgan Chem, Moscow 117997, Russia.
   [Palkina, Kseniia A.; Shakhova, Ekaterina S.; Balakireva, Anastasia V.; Markina, Nadezhda M.] Planta LLC, Moscow 121205, Russia.
   [Ipatova, Daria A.] Pirogov Russian Natl Res Med Univ, Sch Pharm, Fac Biomed, Moscow 117997, Russia.
C3 Russian Academy of Sciences; Pushchino Scientific Center for Biological
   Research (PSCBI) of the Russian Academy of Sciences; Institute of
   Bioorganic Chemistry of the Russian Academy of Sciences; Pirogov Russian
   National Research Medical University
RP Markina, NM (corresponding author), Russian Acad Sci, Dept Biomol Chem, Shemyakin Ovchinnikov Inst Bioorgan Chem, Moscow 117997, Russia.; Markina, NM (corresponding author), Planta LLC, Moscow 121205, Russia.
EM ksenia.palkina@planta.bio; ipatova.daria@yandex.ru;
   ekaterina.shakhova@planta.bio; anastasia@planta.bio;
   nadya.markina@planta.bio
RI Markina, Nadezhda/AAH-4379-2021; Palkina, Kseniia/AAH-4811-2020;
   Balakireva, Anastasia/AAQ-4082-2020
OI Shakhova, Ekaterina/0000-0002-6345-1330
FU Russian Federation [LS-2605.2020.4]; Russian Foundation for Basic
   Research [18-29-08049]
FX This work was funded by the President of the Russian Federation grant
   for leading scientific schools number LS-2605.2020.4 and by the Russian
   Foundation for Basic Research grant number 18-29-08049.
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NR 106
TC 18
Z9 18
U1 0
U2 14
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2309-608X
J9 J FUNGI
JI J. Fungi
PD MAY
PY 2021
VL 7
IS 5
AR 323
DI 10.3390/jof7050323
PG 13
WC Microbiology; Mycology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Microbiology; Mycology
GA SH7LF
UT WOS:000654314500001
PM 33922000
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Ng, L
   Kaur, P
   Bunnag, N
   Suresh, J
   Sung, ICH
   Tan, QH
   Gruber, J
   Tolwinski, NS
AF Ng, Li Fang
   Kaur, Prameet
   Bunnag, Nawat
   Suresh, Jahnavi
   Sung, Isabelle Chiao Han
   Tan, Qian Hui
   Gruber, Jan
   Tolwinski, Nicholas S.
TI WNT Signaling in Disease
SO CELLS
LA English
DT Review
DE WNT; cancer; metabolic syndrome; Alzheimer's disease
ID WNT/BETA-CATENIN PATHWAY; RECEPTOR-RELATED PROTEIN-5; SMALL-MOLECULE
   INHIBITOR; FAMILIAL ADENOMATOUS POLYPOSIS; GLYCOGEN-SYNTHASE KINASE-3;
   FRAGILE-X-SYNDROME; CANCER STEM-CELLS; BETA-CATENIN; MATRIX
   METALLOPROTEINASE-7; OXIDATIVE STRESS
AB Developmental signaling pathways control a vast array of biological processes during embryogenesis and in adult life. The WNT pathway was discovered simultaneously in cancer and development. Recent advances have expanded the role of WNT to a wide range of pathologies in humans. Here, we discuss the WNT pathway and its role in human disease and some of the advances in WNT-related treatments.
C1 [Ng, Li Fang; Kaur, Prameet; Bunnag, Nawat; Suresh, Jahnavi; Sung, Isabelle Chiao Han; Tan, Qian Hui; Gruber, Jan; Tolwinski, Nicholas S.] Yale NUS Coll, Res Labs E6, Div Sci, E6,5 Engn Dr 1,04-02, Singapore 117608, Singapore.
C3 Yale NUS College
RP Tolwinski, NS (corresponding author), Yale NUS Coll, Res Labs E6, Div Sci, E6,5 Engn Dr 1,04-02, Singapore 117608, Singapore.
EM Nicholas.tolwinski@yale-nus.edu.sg
RI Tolwinski, Nicholas/Q-5782-2019
OI Tolwinski, Nicholas/0000-0002-8507-2737; Bunnag,
   Nawat/0000-0002-2594-0459; Sung, Isabelle Chiao Han/0000-0002-1449-4836;
   Tan, Qian Hui/0000-0002-5271-5476
FU Ministry of Education of Singapore through Yale-NUS [IG17-LR006,
   IG18-LR001]
FX We are thankful for the funding provided by Ministry of Education of
   Singapore through Yale-NUS grants IG17-LR006 and IG18-LR001.
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NR 321
TC 177
Z9 195
U1 2
U2 48
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2073-4409
J9 CELLS-BASEL
JI Cells
PD AUG
PY 2019
VL 8
IS 8
AR 826
DI 10.3390/cells8080826
PG 32
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA IV8TI
UT WOS:000484537500059
PM 31382613
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Hannou, SA
   Haslam, DE
   McKeown, NM
   Herman, MA
AF Hannou, Sarah A.
   Haslam, Danielle E.
   McKeown, Nicola M.
   Herman, Mark A.
TI Fructose metabolism and metabolic disease
SO JOURNAL OF CLINICAL INVESTIGATION
LA English
DT Review
ID SWEETENED BEVERAGE CONSUMPTION; ELEMENT-BINDING PROTEIN; HEPATIC
   INSULIN-RESISTANCE; CORONARY-HEART-DISEASE; DE-NOVO LIPOGENESIS;
   GROWTH-FACTOR 21; URIC-ACID; DIETARY FRUCTOSE; OXIDATIVE STRESS; ALDOSE
   REDUCTASE
AB Increased sugar consumption is increasingly considered to be a contributor to the worldwide epidemics of obesity and diabetes and their associated cardiometabolic risks. As a result of its unique metabolic properties, the fructose component of sugar may be particularly harmful. Diets high in fructose can rapidly produce all of the key features of the metabolic syndrome. Here we review the biology of fructose metabolism as well as potential mechanisms by which excessive fructose consumption may contribute to cardiometabolic disease.
C1 [Hannou, Sarah A.; Herman, Mark A.] Duke Univ, Med Ctr, Div Endocrinol & Metab, Durham, NC 27705 USA.
   [Hannou, Sarah A.; Herman, Mark A.] Duke Univ, Med Ctr, Duke Mol Physiol Inst, Durham, NC 27705 USA.
   [Haslam, Danielle E.; McKeown, Nicola M.] Tufts Univ, Nutr Epidemiol Program, Jean Mayer US Dept Agr, Human Nutr Res Ctr Aging, Boston, MA 02111 USA.
C3 Duke University; Duke University; Tufts University; United States
   Department of Agriculture (USDA)
RP Herman, MA (corresponding author), Duke Univ, 300 N Duke St,Carmichael Bldg, Durham, NC 27705 USA.
EM mark.herman@duke.edu
RI Herman, Mark/H-3232-2012; Haslam, Danielle/V-8846-2019; hannou,
   sarah/AAT-2902-2020
OI Hannou, Sarah A/0000-0003-4780-5773; Haslam,
   Danielle/0000-0003-0144-3287; Herman, Mark/0000-0001-6979-103X
FU American Heart Association [16CSA28590003]; NIH [R01DK100425,
   5T32HL069772-15]; US Department of Agriculture Agricultural Research
   Service [58-1950-4-003]
FX This work is supported by American Heart Association 16CSA28590003 (to
   MAH and NMM), NIH R01DK100425 (to MAH), NIH 5T32HL069772-15 (to DEH),
   and US Department of Agriculture Agricultural Research Service agreement
   58-1950-4-003 (to NMM).
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NR 193
TC 378
Z9 415
U1 14
U2 173
PU AMER SOC CLINICAL INVESTIGATION INC
PI ANN ARBOR
PA 2015 MANCHESTER RD, ANN ARBOR, MI 48104 USA
SN 0021-9738
EI 1558-8238
J9 J CLIN INVEST
JI J. Clin. Invest.
PD FEB 1
PY 2018
VL 128
IS 2
BP 545
EP 555
DI 10.1172/JCI96702
PG 11
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA FV5YY
UT WOS:000424659500001
PM 29388924
OA Green Published, Bronze, Green Submitted
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Sundaram, V
   Morgan, TR
AF Sundaram, Vinay
   Morgan, Timothy R.
TI Will Studies in Nonalcoholic Steatohepatitis Help Manage Alcoholic
   Steatohepatitis?
SO CLINICS IN LIVER DISEASE
LA English
DT Article
DE Alcoholic cirrhosis; Fatty liver disease; Alcoholic liver disease; Anti
   -fibrotic; Anti-inflammatory
ID ENDOPLASMIC-RETICULUM STRESS; INSULIN-RESISTANCE; LIVER; CELLS;
   PATHOGENESIS; INFLAMMATION; ACID; MICE; PROGRESSION; METABOLISM
AB Hepatic steatosis and steatohepatitis have several etiologies; the most common are alcoholic steatohepatitis (ASH) and obesity/metabolic syndrome-induced steatohepatitis, also known as nonalcoholic steatohepatitis (NASH). Although the etiology of these 2 conditions is different, they share pathways to disease progression and severity. They also have differences in physiologic pathways, and shared and divergent mechanisms can be therapeutic targets. There is no approved pharmacologic therapy for NASH, but several molecules are under study. Focus remains on modulation of insulin resistance, oxidative stress, the inflammatory cascade, hepatic fibrosis, and cell death. This review provides an overview of pathophysiologic similarities and differences between ASH and NASH.
C1 [Sundaram, Vinay] Cedars Sinai Med Ctr, Dept Med, Comprehens Transplant Ctr, 8900 Beverly Blvd,Suite 250, Los Angeles, CA 90048 USA.
   [Morgan, Timothy R.] VA Long Beach Healthcare Syst, Gastroenterol Sect, 5901 East Seventh St 11G, Long Beach, CA 90822 USA.
C3 Cedars Sinai Medical Center; US Department of Veterans Affairs; Veterans
   Health Administration (VHA); VA Long Beach Healthcare System
RP Morgan, TR (corresponding author), VA Long Beach Healthcare Syst, Gastroenterol Sect, 5901 East Seventh St 11G, Long Beach, CA 90822 USA.
EM Timothy.morgan@va.gov
FU National Institute on Alcohol Abuse and Alcoholism [U01 AA 21886]
FX Supported in part by a grant from the National Institute on Alcohol
   Abuse and Alcoholism (U01 AA 21886) to Dr T.R. Morgan.
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NR 59
TC 6
Z9 6
U1 0
U2 6
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 1089-3261
EI 1557-8224
J9 CLIN LIVER DIS
JI Clin. Liver Dis.
PD FEB
PY 2019
VL 23
IS 1
BP 157
EP +
DI 10.1016/j.cld.2018.09.008
PG 10
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA HF6TY
UT WOS:000454372400014
PM 30454829
DA 2025-06-11
ER

PT J
AU Yu, EPK
   Bennett, MR
AF Yu, Emma P. K.
   Bennett, Martin R.
TI The role of mitochondrial DNA damage in the development of
   atherosclerosis
SO FREE RADICAL BIOLOGY AND MEDICINE
LA English
DT Review
DE Mitochondria; Atherosclerosis; Inflammation
ID PERMEABILITY TRANSITION PORE; SMOOTH-MUSCLE-CELLS; NLRP3 INFLAMMASOME;
   OXIDATIVE STRESS; ACCELERATES ATHEROSCLEROSIS; PROMOTES ATHEROSCLEROSIS;
   ENERGY HOMEOSTASIS; METABOLIC SYNDROME; MTDNA MUTATIONS; ATP SYNTHASE
AB Mitochondria are the cellular powerhouses, fuelling metabolic processes through their generation of ATP. However we now recognise that these organelles also have pivotal roles in producing reactive oxygen species (ROS) and in regulating cell death, inflammation and metabolism. Mitochondrial dysfunction therefore leads to oxidative stress, cell death, metabolic dysfunction and inflammation, which can all promote atherosclerosis. Recent evidence indicates that mitochondrial DNA (mtDNA) damage is present and promotes atherosclerosis through mitochondrial dysfunction. We will review the mechanisms that link mtDNA damage with atherosclerotic disease, and identify mitochondrial processes that may have therapeutic benefit. (C) 2016 Elsevier Inc. All rights reserved.
C1 [Yu, Emma P. K.; Bennett, Martin R.] Univ Cambridge, Addenbrookes Hosp, Addenbrookes Ctr Clin Invest, Div Cardiovasc Med, Box 110, Cambridge CB2 2QQ, England.
C3 University of Cambridge; Cambridge University Hospitals NHS Foundation
   Trust; Addenbrooke's Hospital
RP Yu, EPK (corresponding author), Univ Cambridge, Addenbrookes Hosp, Addenbrookes Ctr Clin Invest, Div Cardiovasc Med, Box 110, Cambridge CB2 2QQ, England.
EM epky2@cam.ac.uk
OI Bennett, Martin/0000-0002-2565-1825
FU British Heart Foundation [PG/14/69/31032, RG/13/14/30314]; National
   Institute for Health Research Cambridge Biomedical Research Centre;
   Academy of Medical Sciences
FX This work was supported by British Heart Foundation grants
   PG/14/69/31032 and RG/13/14/30314, the National Institute for Health
   Research Cambridge Biomedical Research Centre, and the Academy of
   Medical Sciences.
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NR 86
TC 76
Z9 80
U1 4
U2 37
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0891-5849
EI 1873-4596
J9 FREE RADICAL BIO MED
JI Free Radic. Biol. Med.
PD NOV
PY 2016
VL 100
BP 223
EP 230
DI 10.1016/j.freeradbiomed.2016.06.011
PG 8
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA EC3AH
UT WOS:000387995900023
PM 27320189
DA 2025-06-11
ER

PT J
AU Otte, C
   Hart, S
   Neylan, TC
   Marmar, CR
   Yaffe, K
   Mohr, DC
AF Otte, C
   Hart, S
   Neylan, TC
   Marmar, CR
   Yaffe, K
   Mohr, DC
TI A mete-analysis of cortisol response to challenge in human aging:
   importance of gender
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Review
DE HPA axis; cortisol; aging; gender; Alzheimer; depression
ID PITUITARY-ADRENAL AXIS; DEXAMETHASONE SUPPRESSION TEST;
   CORTICOTROPIN-RELEASING HORMONE; GROWTH-HORMONE; PSYCHOSOCIAL STRESS;
   ELDERLY SUBJECTS; HEALTHY-YOUNG; DEHYDROEPIANDROSTERONE-SULFATE;
   ADRENOCORTICOTROPIC HORMONE; POSTMENOPAUSAL WOMEN
AB An increased cortisol response to challenge is associated with a variety of age-related disorders such as Alzheimer's disease, depression, diabetes, metabolic syndrome, and hypertension. Among the healthy elderly, an increased cortisol response to challenge may be a risk factor for developing these age-related disorders.
   We searched Pubmed, Embase, Psychlnfo, Biosis, and Digital Dissertations (January 1966-June 2003) and included 45 parallel-group (young vs. old subjects) studies that used either a pharmacological or psychological challenge in healthy volunteers and measured cortisol response to challenge. We calculated effect sizes (Cohen's d) for the standardized mean differences between groups.
   Compared to younger controls (n = 670, mean age 28 years +/-5), older subjects (n = 625, 69 +/- 6) showed a larger cortisol response to challenge defined as stronger response to stimulation or less inhibition after a suppression test (d = 0.42, 95% confidence interval (Cl), 0.26-0.57). The effect of age on cortisol release was significantly stronger in women (d = 0.65, 95% Cl 0.34-0.97) than men (d = 0.24, 95% Cl 0.02-0.47).
   Our results demonstrate that aging increases the cortisol response to challenge. This effect of age on cortisol response is almost three-fold stronger in women than men. Prospective studies should explore whether the higher cortisol response in the elderly is a risk factor for developing neuropsychiatric and medical disorders. (C) 2004 Elsevier Ltd. All rights reserved.
C1 Univ Calif San Francisco, Dept Psychiat, San Francisco, CA 94143 USA.
   Vet Affairs Med Ctr, San Francisco, CA 94121 USA.
   Univ Hamburg, Dept Psychiat & Psychotherapy, D-20246 Hamburg, Germany.
   Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94143 USA.
   Univ Calif San Francisco, Dept Epidemiol, San Francisco, CA 94143 USA.
C3 University of California System; University of California San Francisco;
   US Department of Veterans Affairs; Veterans Health Administration (VHA);
   University of Hamburg; University of California System; University of
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   California San Francisco
RP Univ Calif San Francisco, Dept Psychiat, San Francisco, CA 94143 USA.
EM otte@uke.uni-hamburg.de
RI Yaffe, Kristine/LLL-8209-2024; Hart, Stacey/E-4819-2011; Marmar,
   Charles/O-1902-2017
OI Mohr, David/0000-0002-5443-7596; Otte, Christian/0000-0002-4051-997X
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NR 123
TC 304
Z9 342
U1 0
U2 27
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
EI 1873-3360
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD JAN
PY 2005
VL 30
IS 1
BP 80
EP 91
DI 10.1016/j.psyneuen.2004.06.002
PG 12
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA 858TL
UT WOS:000224214700009
PM 15358445
DA 2025-06-11
ER

PT J
AU Tao, LC
   Shi, J
   Yang, XY
   Yang, L
   Hua, F
AF Tao, Lichan
   Shi, Jia
   Yang, Xiaoyu
   Yang, Ling
   Hua, Fei
TI The Exosome: a New Player in Diabetic Cardiomyopathy
SO JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
LA English
DT Review
DE Exosomes; Diabetic cardiomyopathy
ID EXTRACELLULAR VESICLES; OXIDATIVE STRESS; DENDRITIC CELLS;
   MICROVESICLES; EXERCISE; CARDIOMYOCYTES; BIOMARKERS; MICRORNAS;
   INTERVENTION; ANGIOGENESIS
AB Diabetic cardiomyopathy (DCM) or diabetes-induced cardiac dysfunction is a direct consequence of uncontrolled metabolic syndrome and occurs worldwide. However, the underlying cellular and molecular mechanisms remain poorly understood. Recently, exosomes have attracted considerable interest for their use as efficient, targeted, and non-immunogenic delivery systems for biological molecules or pharmacotherapies. This review will summarize the fast-developing field of the regulation and function of exosomes in DCM, affording valuable insights and therapeutic opportunities in combatting diabetes-related cardiac disorder for modern human health.
C1 [Tao, Lichan; Yang, Xiaoyu; Yang, Ling] Soochow Univ, Affiliated Hosp 3, Dept Cardiol, Changzhou City 213003, Peoples R China.
   [Shi, Jia] Soochow Univ, Affiliated Hosp 3, Dept Neurosurg, Changzhou City 213003, Peoples R China.
   [Hua, Fei] Soochow Univ, Affiliated Hosp 3, Dept Endocrinol, Changzhou City 213003, Peoples R China.
C3 Soochow University - China; Soochow University - China; Soochow
   University - China
RP Yang, L (corresponding author), Soochow Univ, Affiliated Hosp 3, Dept Cardiol, Changzhou City 213003, Peoples R China.; Hua, F (corresponding author), Soochow Univ, Affiliated Hosp 3, Dept Endocrinol, Changzhou City 213003, Peoples R China.
EM jsczyangling@163.com; czhuafei@vip.sina.com
RI Yang, Xiaoyu/AAJ-4203-2021; TAO, Li/HIR-4254-2022; Hua,
   Fei/AAT-2677-2020
FU National Natural Science Foundation of China [81700343]; Natural Science
   Foundation of Jiangsu Province of China [BK20170296]; Changzhou
   High-Level Medical Talents Training Project [2016ZCLJ020]
FX This work was supported by the grants from National Natural Science
   Foundation of China (81700343 to Lichan Tao), Natural Science Foundation
   of Jiangsu Province of China (BK20170296 to Lichan Tao), and Changzhou
   High-Level Medical Talents Training Project (2016ZCLJ020 to Fei Hua).
CR [Anonymous], J CIRC BIOMARK
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NR 45
TC 19
Z9 21
U1 4
U2 39
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1937-5387
EI 1937-5395
J9 J CARDIOVASC TRANSL
JI J. Cardiovasc. Transl. Res.
PD FEB
PY 2019
VL 12
IS 1
SI SI
BP 62
EP 67
DI 10.1007/s12265-018-9825-x
PG 6
WC Cardiac & Cardiovascular Systems; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Research & Experimental Medicine
GA HM4JH
UT WOS:000459439000009
PM 30251219
DA 2025-06-11
ER

PT J
AU Malin, SK
   Braun, B
AF Malin, Steven K.
   Braun, Barry
TI Impact of Metformin on Exercise-Induced Metabolic Adaptations to Lower
   Type 2 Diabetes Risk
SO EXERCISE AND SPORT SCIENCES REVIEWS
LA English
DT Review
DE obesity; prediabetes; type 2 diabetes; insulin resistance; metabolic
   syndrome; lifestyle modification
ID IMPAIRED GLUCOSE-TOLERANCE; LIFE-STYLE INTERVENTION; AEROBIC EXERCISE;
   CARDIOVASCULAR-DISEASE; INSULIN SENSITIVITY; DOUBLE-BLIND;
   SUPPLEMENTATION; INDIVIDUALS; ASSOCIATION; ADOLESCENTS
AB Combining metformin with exercise has been proposed to improve glucose homeostasis. However, we primarily discuss evidence suggesting that metformin and other pharmacological agents/dietary supplements (e.g., statins, resveratol, or antioxidants) may in fact oppose exercise-induced benefits on insulin sensitivity and cardiometabolic health. We explore the novel hypothesis that attenuation of oxidative stress from exercise by these exogenous compounds blunts metabolic adaptation.
C1 [Malin, Steven K.] Univ Virginia, Dept Kinesiol, Charlottesville, VA 22904 USA.
   [Malin, Steven K.] Univ Virginia, Div Endocrinol & Metab, Charlottesville, VA USA.
   [Braun, Barry] Colorado State Univ, Dept Hlth & Exercise Sci, Ft Collins, CO 80523 USA.
C3 University of Virginia; University of Virginia; Colorado State
   University System; Colorado State University Fort Collins
RP Malin, SK (corresponding author), Univ Virginia, Dept Kinesiol, 225A Mem Gymnasium, Charlottesville, VA 22904 USA.
EM skm6n@virginia.edu
RI Malin, Steven/IXX-0225-2023
OI Malin, Steven/0000-0002-7360-6711
FU Pfizer, Inc.; NIH [5R56 DK081038]; ADA [7-04-JF-10]; ACSM Doctoral
   Student Foundation [S17100000000113]
FX The authors thank Carrie G. Sharoff, Ph.D., Todd A. Hagobian, Ph.D.,
   Stuart R. Chipkin, M.D., Brooke R. Stephens, Ph.D., Rebecca E. Hasson,
   Ph.D., Kirsten Granados, M.S., Richard Viskochil, M.S., Jennifer Rivero,
   M.S., and Robert Gerber, M.S., for outstanding support. We extend our
   appreciation to all the dedicated participants and undergraduate
   research assistants for their help. B. Braun receives consultant fees
   and research funding from Pfizer, Inc. This research was supported by
   NIH 5R56 DK081038 (B. Braun), ADA 7-04-JF-10 (B. Braun), and an ACSM
   Doctoral Student Foundation Grant S17100000000113 (S.K. Malin).
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NR 35
TC 44
Z9 46
U1 0
U2 18
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0091-6331
EI 1538-3008
J9 EXERC SPORT SCI REV
JI Exerc. Sport Sci. Rev.
PD JAN
PY 2016
VL 44
IS 1
BP 4
EP 11
DI 10.1249/JES.0000000000000070
PG 8
WC Physiology; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology; Sport Sciences
GA CY9HO
UT WOS:000366718200004
PM 26583801
DA 2025-06-11
ER

PT J
AU Yu, EPK
   Bennett, MR
AF Yu, Emma P. K.
   Bennett, Martin R.
TI Mitochondrial DNA damage and atherosclerosis
SO TRENDS IN ENDOCRINOLOGY AND METABOLISM
LA English
DT Review
DE mitochondria; atherosclerosis; inflammation
ID PERMEABILITY TRANSITION PORE; SMOOTH-MUSCLE-CELLS; OXIDATIVE STRESS;
   INFLAMMASOME ACTIVATION; NLRP3 INFLAMMASOME; METABOLIC SYNDROME; MTDNA
   MUTATIONS; APOPTOSIS; MICE; ATHEROGENESIS
AB Mitochondria are often regarded as the cellular powerhouses through their ability to generate ATP, the universal fuel for metabolic processes. However, in recent years mitochondria have been recognised as critical regulators of cell death, inflammation, metabolism, and the generation of reactive oxygen species (ROS). Thus, mitochondrial dysfunction directly promotes cell death, inflammation, and oxidative stress and alters metabolism. These are key processes in atherosclerosis and there is now evidence that mitochondrial DNA (mtDNA) damage leads to mitochondrial dysfunction and promotes atherosclerosis directly. In this review we discuss the recent evidence for and mechanisms linking mtDNA defects and atherosclerosis and suggest areas of mitochondrial biology that are potential therapeutic targets.
C1 [Yu, Emma P. K.; Bennett, Martin R.] Univ Cambridge, Addenbrookes Hosp, Addenbrookes Ctr Clin Invest, Div Cardiovasc Med, Cambridge CB2 2QQ, England.
C3 Cambridge University Hospitals NHS Foundation Trust; Addenbrooke's
   Hospital; University of Cambridge
RP Yu, EPK (corresponding author), Univ Cambridge, Addenbrookes Hosp, Addenbrookes Ctr Clin Invest, Div Cardiovasc Med, Box 110, Cambridge CB2 2QQ, England.
EM epky2@cam.ac.uk
OI Bennett, Martin/0000-0002-2565-1825
FU Medical Research Council [G0800784, G1000847] Funding Source: Medline;
   MRC [G1000847, G0800784] Funding Source: UKRI
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NR 63
TC 108
Z9 120
U1 4
U2 40
PU ELSEVIER SCIENCE LONDON
PI LONDON
PA 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND
SN 1043-2760
EI 1879-3061
J9 TRENDS ENDOCRIN MET
JI Trends Endocrinol. Metab.
PD SEP
PY 2014
VL 25
IS 9
BP 481
EP 487
DI 10.1016/j.tem.2014.06.008
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA AO8OD
UT WOS:000341612900007
PM 25034130
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Dallman, MF
   Akana, SF
   Bhatnagar, S
   Bell, ME
   Strack, AM
AF Dallman, MF
   Akana, SF
   Bhatnagar, S
   Bell, ME
   Strack, AM
TI Bottomed out: metabolic significance of the circadian trough in
   glucocorticoid concentrations
SO INTERNATIONAL JOURNAL OF OBESITY
LA English
DT Article; Proceedings Paper
CT 8th International Congress on Endocrinology of Obesity Basic, Clinical
   and Therapeutic Aspects
CY SEP, 1998
CL VENICE, ITALY
DE HPA axis; feedback; MR; GR; insulin; obesity; fat stores; food intake
ID PITUITARY-ADRENAL AXIS; CORTICOTROPIN-RELEASING HORMONE; MAJOR
   DEPRESSIVE-ILLNESS; CLINICAL RESEARCH-CENTER; CORTISOL SECRETION;
   ANOREXIA-NERVOSA; EXOGENOUS CORTICOSTERONE; FAT DISTRIBUTION; CHRONIC
   STRESS; DIABETIC RATS
AB Mild chronic stressors characteristically increase circadian trough corticosteroid concentrations in rats and man. The elevation in trough concentrations is often accompanied by a reduction in peak concentrations and no change in the dairy mean values. Here we point out that elevation of trough glucocorticoids, probably through daily increases of glucocorticoid receptor occupancy, has major metabolic effects that bias organisms toward storage of calories as fat. Thus. chronic mild stress, by overriding the normal mineralocorticoid receptor-mediated corticosteroid feedback regulation of trough CRF and ACTH secretion, facilitates development of the metabolic syndrome.
C1 Univ Calif San Francisco, Sch Med, Dept Physiol, San Francisco, CA 94143 USA.
   Merck & Co, Dept Pharmacol, Rahway, NJ 07065 USA.
C3 University of California System; University of California San Francisco;
   Merck & Company
RP Dallman, MF (corresponding author), Univ Calif San Francisco, Sch Med, Dept Physiol, San Francisco, CA 94143 USA.
RI Dallman, Mary/B-4816-2010; Bhatnagar, Seema/M-7110-2017
FU NIDDK NIH HHS [DK28172] Funding Source: Medline
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NR 44
TC 89
Z9 102
U1 0
U2 7
PU NATURE PUBLISHING GROUP
PI BASINGSTOKE
PA HOUNDMILLS, BASINGSTOKE RG21 6XS, HAMPSHIRE, ENGLAND
SN 0307-0565
J9 INT J OBESITY
JI Int. J. Obes.
PD JUN
PY 2000
VL 24
SU 2
BP S40
EP S46
DI 10.1038/sj.ijo.0801276
PG 7
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 335NW
UT WOS:000088250400010
PM 10997607
DA 2025-06-11
ER

PT J
AU Sánchez-Villegas, A
   Delgado-Rodríguez, M
   Alonso, A
   Schlatter, J
   Lahortiga, F
   Majem, LS
   Martínez-González, MA
AF Sanchez-Villegas, Almudena
   Delgado-Rodriguez, Miguel
   Alonso, Alvaro
   Schlatter, Javier
   Lahortiga, Francisca
   Serra Majem, Lluis
   Angel Martinez-Gonzalez, Miguel
TI Association of the Mediterranean Dietary Pattern With the Incidence of
   Depression The Seguimiento Universidad de Navarra/University
   of Navarra Follow-up (SUN) Cohort
SO ARCHIVES OF GENERAL PSYCHIATRY
LA English
DT Article
ID POLYUNSATURATED FATTY-ACIDS; METABOLIC SYNDROME; CARDIOVASCULAR-DISEASE;
   ENDOTHELIAL FUNCTION; HOMOCYSTEINE LEVELS; PHYSICAL-ACTIVITY; MAJOR
   DEPRESSION; MENTAL-DISORDERS; RISK-FACTORS; STYLE DIET
AB Context: Adherence to the Mediterranean dietary pattern (MDP) is thought to reduce inflammatory, vascular, and metabolic processes that may be involved in the risk of clinical depression.
   Objective: To assess the association between adherence to the MDP and the incidence of clinical depression.
   Design: Prospective study that uses a validated 136-item food frequency questionnaire to assess adherence to the MDP. The MDP score positively weighted the consumption of vegetables, fruit and nuts, cereal, legumes, and fish; the monounsaturated- to saturated-fatty-acids ratio; and moderate alcohol consumption, whereas meat or meat products and whole-fat dairy were negatively weighted.
   Setting: A dynamic cohort of university graduates (Seguimiento Universidad de Navarra/University of Navarra Follow-up [SUN] Project).
   Participants: A total of 10094 initially healthy Spanish participants from the SUN Project participated in the study. Recruitment began on December 21, 1999, and is ongoing.
   Main Outcome Measure: Participants were classified as having incident depression if they were free of depression and antidepressant medication at baseline and reported a physician-made diagnosis of clinical depression and/or antidepressant medication use during follow-up.
   Results: After a median follow-up of 4.4 years, 480 new cases of depression were identified. The multiple adjusted hazard ratios (95% confidence intervals) of depression for the 4 upper successive categories of adherence to the MDP(taking the category of lowest adherence as reference) were 0.74 (0.57-0.98), 0.66 (0.50-0.86), 0.49 (0.36-0.67), and 0.58 (0.44-0.77) (P for trend <.001). Inverse dose-response relationships were found for fruit and nuts, the monounsaturated- to saturated-fatty-acids ratio, and legumes.
   Conclusions: Our results suggest a potential protective role of the MDP with regard to the prevention of depressive disorders; additional longitudinal studies and trials are needed to confirm these findings.
C1 [Angel Martinez-Gonzalez, Miguel] Univ Navarra, Dept Prevent Med & Publ Hlth, Univ Navarra Clin, E-31080 Pamplona, Spain.
   [Sanchez-Villegas, Almudena; Serra Majem, Lluis] Univ Las Palmas Gran Canaria, Dept Clin Sci, Las Palmas Gran Canaria, Spain.
   [Delgado-Rodriguez, Miguel] Univ Jaen, Div Prevent Med & Publ Hlth, Jaen, Spain.
   [Schlatter, Javier; Lahortiga, Francisca] Univ Navarra, Dept Psychiat & Med Psychol, E-31080 Pamplona, Spain.
   [Alonso, Alvaro] Univ Minnesota, Sch Publ Hlth, Div Epidemiol & Community Hlth, Minneapolis, MN USA.
C3 University of Navarra; Universidad de Las Palmas de Gran Canaria;
   Universidad de Jaen; University of Navarra; University of Minnesota
   System; University of Minnesota Twin Cities
RP Martínez-González, MA (corresponding author), Univ Navarra, Dept Prevent Med & Publ Hlth, Univ Navarra Clin, E-31080 Pamplona, Spain.
RI Sanchez-Villegas, Almudena/T-6733-2019; Martinez-Gonzalez,
   Miguel/AAE-7669-2019; ALONSO GOMEZ, ANGEL/HLG-2476-2023; Rodríguez,
   Miguel/KCZ-1828-2024; Serra-Majem, Lluis/I-6708-2019; Lahortiga-Ramos,
   Francisca/H-9363-2017; Alonso, Alvaro/A-4917-2010; Delgado Rodriguez,
   Miguel/H-4940-2017
OI Sanchez Villegas, Almudena/0000-0001-7733-9238; Lahortiga-Ramos,
   Francisca/0000-0001-7624-6902; Martinez-Gonzalez, Miguel
   A./0000-0002-3917-9808; Alonso, Alvaro/0000-0002-2225-8323; Serra-Majem,
   Lluis/0000-0002-9658-9061; Delgado Rodriguez, Miguel/0000-0002-3838-2548
FU Spanish Government Instituto de Salud Carlos III; Fondo de
   Investigaciones Sanitarias [PI042241, PI040233, PI050976, PI070240,
   PI0801943, RD 06/0045]; Navarra Regional Government project [PI41/2005]
FX The Spanish Government Instituto de Salud Carlos III, Fondo de
   Investigaciones Sanitarias, projects PI042241, PI040233, PI050976,
   PI070240, PI0801943, and RD 06/0045 and the Navarra Regional Government
   project PI41/2005 supported the study.
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NR 64
TC 434
Z9 472
U1 3
U2 72
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 0003-990X
EI 1538-3636
J9 ARCH GEN PSYCHIAT
JI Arch. Gen. Psychiatry
PD OCT
PY 2009
VL 66
IS 10
BP 1090
EP 1098
DI 10.1001/archgenpsychiatry.2009.129
PG 9
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 502YE
UT WOS:000270496100006
PM 19805699
DA 2025-06-11
ER

PT J
AU Alla, V
   Bonkovsky, HL
AF Alla, V
   Bonkovsky, HL
TI Iron in nonhemochromatotic liver disorders
SO SEMINARS IN LIVER DISEASE
LA English
DT Review
DE alcohol; cirrhosis; hepatitis C; iron; nonalcoholic fatty liver disease;
   nonalcoholic steatohepatitis; porphyria cutanea tarda
ID CHRONIC HEPATITIS-C; PORPHYRIA-CUTANEA-TARDA; NONALCOHOLIC FATTY LIVER;
   INTERFERON-ALPHA THERAPY; CHRONIC VIRAL-HEPATITIS; ERYTHROCYTE
   UROPORPHYRINOGEN DECARBOXYLASE; INSULIN-RESISTANCE SYNDROME; LONG-TERM
   RESPONSE; HFE GENE-MUTATIONS; HEMOCHROMATOSIS GENE
AB Iron is essential for cellular functions, but in excessive amounts it is toxic to cells. The harmful effects are related to increased oxidative stress and production of reactive oxygen species causing oxidative damage to lipids, proteins, and nucleic acids. Heavy iron overload as occurs in primary and secondary hemochromatosis can cause fibrosis of various parenchymal organs such as the liver, heart, and pancreas. Lesser degrees of hepatic iron deposition are also associated with, and seem to be risk factors for, certain nonhemochromatotic liver diseases. Porphyria cutanea tarda is associated with hepatic iron overload and responds to iron-reduction therapy. Other recent evidence indicates that the prevalence of HFE gene mutations is increased in chronic viral hepatitis and that patients with chronic hepatitis C harboring especially the C282Y mutation are more likely to suffer from advanced hepatic fibrosis or cirrhosis and to do so at younger ages. In this article we review selected nonhemochromatotic disorders in which iron can play an important comorbid role.
C1 Univ Connecticut, Ctr Hlth, Dept Med, Farmington, CT 06030 USA.
   Univ Connecticut, Ctr Hlth, Dept Mol, Farmington, CT 06030 USA.
   Univ Connecticut, Ctr Hlth, Dept Microbial, Farmington, CT 06030 USA.
   Univ Connecticut, Ctr Hlth, Dept Biol Struct, Farmington, CT 06030 USA.
   Univ Connecticut, Ctr Hlth, Liver Biliary Pancreat Ctr, Farmington, CT 06030 USA.
C3 University of Connecticut; University of Connecticut; University of
   Connecticut; University of Connecticut; University of Connecticut
RP Univ Connecticut, Ctr Hlth, Dept Med, MC 1111,263 Farmington Ave, Farmington, CT 06030 USA.
EM bonkovsky@uchc.edu
RI Bonkovsky, Herbert/AAH-1892-2021
FU NIDDK NIH HHS [UO1 DK065193, N01 DK92326, R01 DK38825] Funding Source:
   Medline
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NR 120
TC 103
Z9 109
U1 0
U2 4
PU THIEME MEDICAL PUBL INC
PI NEW YORK
PA 333 SEVENTH AVE, NEW YORK, NY 10001 USA
SN 0272-8087
EI 1098-8971
J9 SEMIN LIVER DIS
JI Semin. Liver Dis.
PY 2005
VL 25
IS 4
BP 461
EP 472
DI 10.1055/s-2005-923317
PG 12
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 990KY
UT WOS:000233743000009
PM 16315139
DA 2025-06-11
ER

PT J
AU Kim, J
   Jung, EJ
   Moon, SS
   Seo, M
AF Kim, Jongwan
   Jung, Eun Jung
   Moon, Seong-Su
   Seo, Minchul
TI Protective effect of carbenoxolone on ER stress-induced cell death in
   hypothalamic neurons
SO BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
LA English
DT Article
DE Carbenoxolone (CBX); Endoplasmic reticulum stress; Hypothalamus;
   Apoptosis; Reactive oxygen species
ID ENDOPLASMIC-RETICULUM STRESS; 11-BETA-HYDROXYSTEROID DEHYDROGENASE
   TYPE-1; INSULIN SENSITIVITY; METABOLIC SYNDROME; FATTY LIVER;
   BODY-WEIGHT; FOOD-INTAKE; OBESITY; MICE; PATHOGENESIS
AB Hypothalamic endoplasmic reticulum (ER) stress is known to be increased in obesity. Induction of ER stress on hypothalamic neurons has been reported to cause hypothalamic neuronal apoptosis and malfunction of energy balance, leading to obesity. Carbenoxolone is an 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1) inhibitor that converts inactive glucocorticoid into an active form. In addition to its metabolic effect via enzyme inhibitory action, carbenoxolone has shown anti-apoptotic activity in several studies. In this study, the direct effects of carbenoxolone on ER stress and cell death in hypothalamic neurons were investigated. Carbenoxolone attenuated tunicamycin induced ER stress-mediated molecules such as spliced XBP1, ATF4, ATF6, CHOP, and ROS generation. In vivo study also revealed that carbenoxolone decreased tunicamycin-induced ER stress in the hypothalamus. In conclusion, the results of this study show that carbenoxolone has protective effects against tunicamycin induced-ER stress and apoptosis in hypothalamic neurons, suggesting its direct protective effects against obesity. Further study is warranted to clarify the effects of carbenoxolone on hypothalamic regulation of energy balance in obesity. (C) 2015 Elsevier Inc. All rights reserved.
C1 [Kim, Jongwan; Moon, Seong-Su; Seo, Minchul] Dongguk Univ, Coll Med, Inst Med Res, Gyeongju, South Korea.
   [Jung, Eun Jung] Dongguk Univ, Coll Med, Dept Biochem, Gyeongju, South Korea.
   [Moon, Seong-Su] Dongguk Univ, Coll Med, Dept Internal Med, Gyeongju, South Korea.
   [Kim, Jongwan] Dongguk Univ, Coll Med, Grad Sch, Dept Anat, Gyeongju, South Korea.
C3 Dongguk University; Dongguk University; Dongguk University; Dongguk
   University
RP Seo, M (corresponding author), Dongguk Univ, Coll Med, Dept Internal Med, Gyeongju, South Korea.
EM drmoonss@hanmail.net; nansmc@hanmail.net
FU Dongguk University [K-2014-G0002-00009]
FX This work was supported by the Dongguk University research fund of
   K-2014-G0002-00009.
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NR 33
TC 10
Z9 10
U1 0
U2 6
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0006-291X
EI 1090-2104
J9 BIOCHEM BIOPH RES CO
JI Biochem. Biophys. Res. Commun.
PD DEC 25
PY 2015
VL 468
IS 4
BP 793
EP 799
DI 10.1016/j.bbrc.2015.11.034
PG 7
WC Biochemistry & Molecular Biology; Biophysics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics
GA DA5UQ
UT WOS:000367868500044
PM 26577412
DA 2025-06-11
ER

PT J
AU Pike, IL
AF Pike, IL
TI The nutritional consequences of pregnancy sickness - A critique of a
   hypothesis
SO HUMAN NATURE-AN INTERDISCIPLINARY BIOSOCIAL PERSPECTIVE
LA English
DT Article
DE East Africa; evolutionary medicine; maternal nutrition; pastoralists;
   pregnancy outcome
ID LOW-BIRTH-WEIGHT; CORTICOTROPIN-RELEASING HORMONE; INSULIN-RESISTANCE
   SYNDROME; CHORIONIC-GONADOTROPIN; REPRODUCTIVE HISTORY; MATERNAL WEIGHT;
   NOMADIC TURKANA; FUNDAL HEIGHT; AFRICAN WOMEN; BACON CHOW
AB The purpose of this paper is to assess Profet's (1992) and others' hypothesis that nausea and vomiting in pregnancy (NVP) is adaptive. A number of studies have found an association between NVP and a decreased risk for early fetal loss (<20 weeks). It is assumed that the adaptive benefits of improved survivorship associated with NVP outweigh the minimal nutritional consequences. However, in populations that experience marginal levels of nutrition, NVP may have important nutritional consequences. To test these potential consequences, a study on NVP, nutritional status, and pregnancy outcome was conducted among Turkana pastoralists, who experience seasonal and chronic nutritional stress. Interviews and anthropometric assessments were conducted on 68 pregnant Turkana women of Kenya during a 1993-1994 field season. The results from the case study suggest that women who experience NVP do encounter nutritional consequences in the later stages of pregnancy and are more likely to experience poor pregnancy outcomes. These results suggest that NVP may not be adaptive in all environmental settings, particularly among marginally nourished populations.
C1 Ohio State Univ, Dept Anthropol, Columbus, OH 43210 USA.
C3 University System of Ohio; Ohio State University
RP Ohio State Univ, Dept Anthropol, 115 Lord Hall,124 W 17th Ave, Columbus, OH 43210 USA.
EM pike.21@osu.edu
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NR 81
TC 15
Z9 18
U1 0
U2 6
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1045-6767
EI 1936-4776
J9 HUM NATURE-INT BIOS
JI Hum. Nat.-Interdiscip. Biosoc. Perspect.
PY 2000
VL 11
IS 3
BP 207
EP 232
DI 10.1007/s12110-000-1011-5
PG 26
WC Anthropology; Social Sciences, Biomedical
WE Social Science Citation Index (SSCI)
SC Anthropology; Biomedical Social Sciences
GA 360AY
UT WOS:000089645300001
PM 26193475
DA 2025-06-11
ER

PT J
AU Henley, DE
   Lightman, SL
AF Henley, D. E.
   Lightman, S. L.
TI NEW INSIGHTS INTO CORTICOSTEROID-BINDING GLOBULIN AND GLUCOCORTICOID
   DELIVERY
SO NEUROSCIENCE
LA English
DT Article
DE corticosteroid-binding globulin; CBG; transcortin; cortisol;
   glucocorticoid; hypothalamic-pituitary-adrenal axis
ID STEROID-PROTEIN INTERACTIONS; INSULIN-RESISTANCE SYNDROME;
   PITUITARY-ADRENAL AXIS; CELL-MEMBRANES; CEREBROSPINAL-FLUID; SALIVARY
   CORTISOL; HORMONE RECEPTORS; STRESS RESPONSES; RAT; EXPRESSION
AB Corticosteroid-binding globulin (CBG) binds cortisol with high affinity and facilitates its transport in the blood. A recent discovery suggests that CBG may have a role beyond that of a simple transport carrier protein. CBG functions as a protein thermocouple that is exquisitely sensitive to temperature change, releasing cortisol in response to increasing temperatures within the human physiological range. It is also expressed in the human hypothalamus and cerebrospinal fluid, while in the rodent it is also found in other intracellular neuronal locations, suggesting a role in regulating access of glucocorticoids to their receptors in the CNS. Genetic variants of CBG have been detected in man and have been associated with fatigue-pain syndromes and hypotension, again suggesting a potential effect of CBG on the access of cortisol to brain glucocorticoid receptors. These new findings provide the basis for a novel concept of the mechanisms through which the body regulates access of glucocorticoids to the brain and other tissues of the body. (C) 2011 IBRO. Published by Elsevier Ltd. All rights reserved.
C1 [Lightman, S. L.] Univ Bristol, Henry Wellcome Labs Integrat Neurosci & Endocrino, Bristol BS1 3NY, Avon, England.
   [Henley, D. E.] Univ Western Australia, Fac Med Dent & Hlth Sci, Crawley, WA 6009, Australia.
   [Henley, D. E.] Sir Charles Gairdner Hosp, Dept Endocrinol & Diabet, Nedlands, WA 6009, Australia.
C3 University of Bristol; University of Western Australia; University of
   Western Australia; Sir Charles Gairdner Hospital
RP Lightman, SL (corresponding author), Univ Bristol, Henry Wellcome Labs Integrat Neurosci & Endocrino, Whitson St, Bristol BS1 3NY, Avon, England.
EM Stafford.Lightman@bristol.ac.uk
RI Lightman, Stafford/G-2107-2011
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NR 88
TC 84
Z9 96
U1 0
U2 18
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4522
EI 1873-7544
J9 NEUROSCIENCE
JI Neuroscience
PD APR 28
PY 2011
VL 180
BP 1
EP 8
DI 10.1016/j.neuroscience.2011.02.053
PG 8
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 748MV
UT WOS:000289395600001
PM 21371536
DA 2025-06-11
ER

PT J
AU El Asmar, K
   Annan, NB
   Khoury, R
   Colle, R
   Martin, S
   Ghoul, TE
   Trabado, S
   Chanson, P
   Feve, B
   Verstuyft, C
   Becquemont, L
   Corruble, E
AF El Asmar, K.
   Annan, N. B.
   Khoury, R.
   Colle, R.
   Martin, S.
   Ghoul, T. E.
   Trabado, S.
   Chanson, P.
   Feve, B.
   Verstuyft, C.
   Becquemont, L.
   Corruble, E.
TI Non-overweight depressed patients who respond to antidepressant
   treatment have a higher risk of later metabolic syndrome: findings from
   the METADAP cohort
SO PSYCHOLOGICAL MEDICINE
LA English
DT Article
DE Antidepressant; depression; MetS; response to treatment; weight
ID WEIGHT-GAIN; PREDICTORS; METAANALYSIS; ASSOCIATION
AB Background. Major depressive disorder (MDD) is a complex disorder with a significant public health burden. Depression remission is often associated with weight gain, a major risk factor for metabolic syndrome (MetS). The primary objective of our study was to assess prospectively the impact of response to antidepressant treatment on developing MetS in a sample of MDD patients with a current major depressive episode (MDE) and who are newly initiating their treatment.
   Methods. In the 6-month prospective METADAP cohort, non-overweight patients, body mass index <25 kg/m(2), with MDD and a current MDE were assessed for treatment response after 3 months of treatment, and incidence of MetS after 3 and 6 months of treatment. Outcome variables were MetS, number of MetS criteria, and each MetS criterion (high waist circumference, high blood pressure, high triglyceridemia, low high-density lipoprotein-cholesterolemia, and high fasting plasma glucose).
   Results. In total, 98/169 patients (58%) responded to treatment after 3 months. A total of 2.7% (1/38) developed MetS out of which 12.7% (10/79) (p value < 0.001) had responded to treatment after 3 months. The fixed-effect regression models showed that those who responded to treatment after 3 months of follow-up had an 8.6 times higher odds of developing MetS (odds ratio = 8.58, 95% confidence interval 3.89-18.93, p value < 0.001).
   Conclusion. Compared to non-responders, non-overweight patients who responded to treatment after 3 months of antidepressant treatment had a significantly higher risk of developing MetS during the 6 months of treatment. Psychiatrists and nurses should closely monitor the metabolic profile of their patients, especially those who respond to treatment.
C1 [El Asmar, K.; Colle, R.; Martin, S.; Verstuyft, C.; Becquemont, L.; Corruble, E.] Univ Paris Saclay, Fac Med, CESP, MOODS Team,INSERM,UMR 1018, F-94275 Le Kremlin Bicetre, France.
   [El Asmar, K.; Annan, N. B.; Khoury, R.; Ghoul, T. E.] Amer Univ Beirut, Dept Epidemiol & Populat Hlth, Fac Hlth Sci, Beirut, Lebanon.
   [Colle, R.; Martin, S.; Corruble, E.] Hop Univ Paris Saclay, Hop Bicetre, AP HP, Serv Hosp Univ Psychiat Bicetre, F-94275 Le Kremlin Bicetre, France.
   [Trabado, S.; Chanson, P.] Univ Paris Saclay, Fac Med, INSERM, UMR S U1185, F-94275 Le Kremlin Bicetre, France.
   [Trabado, S.; Verstuyft, C.] Hop Univ Paris Saclay, Hop Bicetre, AP HP, Serv Genet Mol Pharmacogenet & Hormonol Bicetre, F-94275 Le Kremlin Bicetre, France.
   [Chanson, P.] Hop Bicetre, AP HP, Ctr Reference Malad Rares Hypophyse, Serv Endocrinol & Malad Reprod, F-94275 Le Kremlin Bicetre, France.
   [Feve, B.] Sorbonne Univ, Hop St Antoine, AP HP,INSERM, Ctr Rech St Antoine,Inst Hosp Univ ICAN,Serv Endo, F-75012 Paris, France.
   [Becquemont, L.] Hop Univ Paris Saclay, Hop Bicetre, AP HP, Ctr Rech Clin, F-94275 Le Kremlin Bicetre, France.
C3 Universite Paris Saclay; Institut National de la Sante et de la
   Recherche Medicale (Inserm); American University of Beirut; Assistance
   Publique Hopitaux Paris (APHP); Hopital Universitaire Bicetre - APHP;
   Universite Paris Saclay; Hopital Universitaire Antoine-Beclere - APHP;
   Universite Paris Saclay; Institut National de la Sante et de la
   Recherche Medicale (Inserm); Universite Paris Saclay; Assistance
   Publique Hopitaux Paris (APHP); Hopital Universitaire Antoine-Beclere -
   APHP; Hopital Universitaire Bicetre - APHP; Assistance Publique Hopitaux
   Paris (APHP); Hopital Universitaire Bicetre - APHP; Hopital
   Universitaire Antoine-Beclere - APHP; Universite Paris Saclay;
   Assistance Publique Hopitaux Paris (APHP); Sorbonne Universite; Hopital
   Universitaire Saint-Antoine - APHP; Institut National de la Sante et de
   la Recherche Medicale (Inserm); Assistance Publique Hopitaux Paris
   (APHP); Hopital Universitaire Bicetre - APHP; Hopital Universitaire
   Antoine-Beclere - APHP; Universite Paris Saclay
RP El Asmar, K (corresponding author), Univ Paris Saclay, Fac Med, CESP, MOODS Team,INSERM,UMR 1018, F-94275 Le Kremlin Bicetre, France.; El Asmar, K (corresponding author), Amer Univ Beirut, Dept Epidemiol & Populat Hlth, Fac Hlth Sci, Beirut, Lebanon.
EM ke05@aub.edu.lb
RI Chanson, Philippe/F-8511-2013; becquemont, laurent/KLD-8162-2024; Colle,
   Romain/IQV-1876-2023; verstuyft, celine/AAU-3343-2021; El Asmar,
   Khalil/A-3530-2019
OI Annan, Beyhan/0009-0006-4557-8203; El Ghoul, Tala/0000-0003-2315-6318;
   El-Khoury, Rayane/0000-0002-8709-6222; El Asmar,
   Khalil/0000-0002-6030-8088
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NR 34
TC 2
Z9 2
U1 2
U2 6
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0033-2917
EI 1469-8978
J9 PSYCHOL MED
JI Psychol. Med.
PD OCT
PY 2023
VL 53
IS 14
BP 6560
EP 6569
DI 10.1017/S0033291722003919
EA JAN 2023
PG 10
WC Psychology, Clinical; Psychiatry; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA W1NW2
UT WOS:000910100300001
PM 36628576
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Schiavon, CC
   Marchetti, E
   Ayala, FO
   Loewe, G
   Bauer, J
   Busnello, FM
   Reppold, CT
AF Schiavon, Cecilia Cesa
   Marchetti, Eduarda
   Ayala, Fernanda Oliveira
   Loewe, Gabriela
   Bauer, Julia
   Busnello, Fernanda Michielin
   Reppold, Caroline Tozzi
TI Positive psychological characteristics in patients with metabolic
   syndrome associated with prospective changes in diet and anthropometric
   factors
SO PLOS ONE
LA English
DT Article
ID HEALTHY EATING INDEX; FOOD-CONSUMPTION; SELF-ESTEEM; WEIGHT-LOSS;
   VALIDATION; OPTIMISM; HOPE; VERSION; METAANALYSIS; QUALITY
AB The prevalence of metabolic syndrome (MetS) is increasing worldwide, and diet therapy plays a key role in treating this disease. Since most patients show difficulties in adhering to nutritional interventions, research on the association of positive psychological characteristics with greater engagement in physical health is relevant to this field. The present study aimed to evaluate the association between positive psychology attributes (optimism, hope, self-esteem, positive/negative affect and life satisfaction) and changes in diet quality and anthropometric parameters of individuals with MetS who received nutritional counseling. The study assessed 63 patients at a nutrition outpatient clinic. Anthropometric parameters and 24-hour food recall data (for evaluation of the Brazilian Healthy Eating Index-Revised-BHEI-R) were collected at the first visit and subsequent return visit (on average five months later). Psychological data were collected at the first visit using validated and standardized scales. The results were adjusted in relation to the depression scores of the patients, which were evaluated using the Beck Depression Inventory-II (BDI-II). Changes in anthropometric factors and in the BHEI-R were assessed, and their associations with the psychological attributes were investigated. The results indicated that positive affect and hope were associated with improvement in the BHEI-R scores (Cohen effect sizes -0.65 and -0.58; p = 0.012 and 0.025, respectively). A significant association was also observed between optimism and a reduction in abdominal circumference (Cohen effect size 0.56; p = 0.031). The associations remained significant even after adjusting for the BDI-II scores (p = 0.022, p = 0.037 and p = 0.05, respectively). No statistically significant associations were observed for the other attributes assessed.The study suggests that some attributes may have a greater influence on the nutritional treatment of MetS and that future studies should be conducted in order to enable effective multidisciplinary interventions to treat MetS.
C1 [Schiavon, Cecilia Cesa; Marchetti, Eduarda; Ayala, Fernanda Oliveira; Loewe, Gabriela; Bauer, Julia; Busnello, Fernanda Michielin; Reppold, Caroline Tozzi] Fed Univ Hlth Sci Porto Alegre UFCSPA, Dept Hlth Sci, Psychol Assessment Lab, Porto Alegre, RS, Brazil.
C3 Universidade Federal de Ciencias da Saude de Porto Alegre
RP Schiavon, CC (corresponding author), Fed Univ Hlth Sci Porto Alegre UFCSPA, Dept Hlth Sci, Psychol Assessment Lab, Porto Alegre, RS, Brazil.
EM cecilia.cesa@gmail.com
RI Busnello, Fernanda/AEX-2991-2022; Cesa, Cecilia/HQY-2615-2023
OI Michielin Busnello, Fernanda/0000-0001-9091-142X
FU Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior - Brasil
   (CAPES); Conselho Nacional de Desenvolvimento Cientifico e Tecnologico
   (CNPq); Coordenacao de Aperfeicoamento de Pessoal de Nivel
   Superior-Brasil (CAPES)
FX This study was financed in part by the Coordenacao de Aperfeicoamento de
   Pessoal de Nivel Superior - Brasil (CAPES) and Conselho Nacional de
   Desenvolvimento Cientifico e Tecnologico (CNPq). Authors who received
   this funding, characterized as a research grant were CCS, GL and CTR.
   The funders had no role in study design, data collection and analysis,
   decision to publish, or preparation of the manuscript.The authors would
   like to thank professor Sinara Laurini Rossato, researcher at the
   Department of Nutrition of the Harvard School of Public Health, for
   providing training on the use of the NDSR software and Sheyla de Liz,
   researcher at the Federal University of Santa Catarina, for training in
   performing BHEI-R calculations. This study was financed in part by the
   Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior-Brasil
   (CAPES) and Conselho Nacional de Desenvolvimento Cientifico e
   Tecnologico (CNPq).
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   Zanon C, 2014, SOC INDIC RES, V119, P443, DOI 10.1007/s11205-013-0478-5
   Zanon Cristian, 2013, Psico-USF, V18, P193
NR 72
TC 3
Z9 3
U1 0
U2 6
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD SEP 1
PY 2020
VL 15
IS 9
AR e0236693
DI 10.1371/journal.pone.0236693
PG 19
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Science & Technology - Other Topics
GA NN6BT
UT WOS:000568872300015
PM 32870909
OA Green Published, gold
DA 2025-06-11
ER

PT S
AU Reckelhoff, JF
AF Reckelhoff, Jane F.
BE Kerkhof, PLM
   Miller, VM
TI Sex Differences in Regulation of Blood Pressure
SO SEX-SPECIFIC ANALYSIS OF CARDIOVASCULAR FUNCTION
SE Advances in Experimental Medicine and Biology
LA English
DT Article; Book Chapter
DE Hypertension; Obesity; Metabolic syndrome; Postmenopausal women;
   Hypogonadism; Immune system-mediated hypertension; Androgens; Estrogens;
   Endothelin
ID SPONTANEOUSLY HYPERTENSIVE-RATS; RENIN-ANGIOTENSIN SYSTEM;
   SYMPATHETIC-NERVOUS-SYSTEM; POLYCYSTIC-OVARY-SYNDROME; OXIDATIVE STRESS;
   POSTMENOPAUSAL HYPERTENSION; ARACHIDONIC-ACID; REPLACEMENT THERAPY;
   GENDER-DIFFERENCES; ARTERIAL-PRESSURE
AB Hypertension is one of the leading risk factors for cardiovascular disease, myocardial infarction, and stroke. There are gender differences in the prevalence of hypertension and in the mechanisms responsible for hypertension in humans. This review will discuss the mechanisms for regulation of blood pressure, sex differences that have been identified in animal studies, and the gender differences that have been identified in humans.
C1 [Reckelhoff, Jane F.] Univ Mississippi, Med Ctr, Dept Cell & Mol Biol, Jackson, MS 39216 USA.
   [Reckelhoff, Jane F.] Univ Mississippi, Med Ctr, Womens Hlth Res Ctr, Jackson, MS 39216 USA.
   [Reckelhoff, Jane F.] Univ Mississippi, Med Ctr, Mississippi Ctr Excellence Perinatal Res, Jackson, MS 39216 USA.
C3 University of Mississippi; University of Mississippi Medical Center;
   University of Mississippi Medical Center; University of Mississippi;
   University of Mississippi Medical Center; University of Mississippi
RP Reckelhoff, JF (corresponding author), Univ Mississippi, Med Ctr, Dept Cell & Mol Biol, Jackson, MS 39216 USA.; Reckelhoff, JF (corresponding author), Univ Mississippi, Med Ctr, Womens Hlth Res Ctr, Jackson, MS 39216 USA.; Reckelhoff, JF (corresponding author), Univ Mississippi, Med Ctr, Mississippi Ctr Excellence Perinatal Res, Jackson, MS 39216 USA.
EM jreckelhoff@umc.edu
FU NHLBI NIH HHS [R01 HL069194, P01 HL051971, R01 HL066072] Funding Source:
   Medline; NIGMS NIH HHS [P20 GM121334] Funding Source: Medline; NIMH NIH
   HHS [K02 MH067028] Funding Source: Medline
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NR 81
TC 40
Z9 41
U1 1
U2 7
PU SPRINGER INTERNATIONAL PUBLISHING AG
PI CHAM
PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND
SN 0065-2598
EI 2214-8019
BN 978-3-319-77932-4; 978-3-319-77931-7
J9 ADV EXP MED BIOL
JI Adv.Exp.Med.Biol.
PY 2018
VL 1065
BP 139
EP 151
DI 10.1007/978-3-319-77932-4_9
D2 10.1007/978-3-319-77932-4
PG 13
WC Biology; Cardiac & Cardiovascular Systems; Medicine, Research &
   Experimental
WE Book Citation Index – Science (BKCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics; Cardiovascular System &
   Cardiology; Research & Experimental Medicine
GA BL6GX
UT WOS:000453874000011
PM 30051382
DA 2025-06-11
ER

PT J
AU Lee, K
   Ko, DH
   Lee, JY
AF Lee, Kyujin
   Ko, Duk Han
   Lee, Ji Young
TI Prevalence of Metabolic Syndrome According to Causes of Physical
   Activity Limitation
SO DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
LA English
DT Article
DE metabolic syndrome; physical activity limitation; prevalence
ID UNITED-STATES; RISK-FACTORS; DISEASE; DISABILITY; OBESITY; INTERVENTION;
   PREVENTION; DEPRESSION; INACTIVITY; PEOPLE
AB Purpose: One cause of metabolic syndrome (MetS) is inactivity. This study analyzed the prevalence of MetS due to causes of activity limitation (AL) in adults over 40 years old.
   Paticipants and Methods: Participants included 2885 people aged 40-79 (1198 men and 1687 women) who completed the Korean National Health and Nutrition Survey (KNHANES) conducted between 2013 and 2017. They were divided into two groups based on age: the middle age group (MA) included 1148 total participants, 515 men and 633 women from 40-59 years old; the older age group (OA) included 1737 total participants, 683 men and 1054 women from 60-79 years old. MetS was diagnosed according to the Third Report of the National Cholesterol Education Program and the Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (NCEP-ATP III). Logistic regression was conducted to calculate the odds ratio for MetS prevalence.
   Results: The prevalence of MetS in people with AL increased 1.432-fold in the MA men group, 1.511-fold in the OA men group, 1.546-fold in the MA women group, and 1.565-fold in the OA women group. There were several causes of AL; people with physical activity for diabetes mellitus and hypertension increased MetS prevalence in both sexes and all age groups: MA men group (OR=3.216, 95% CI=1.852-7.354, P=0.034), MA women group (OR=2.159, 95% CI=1.854-5.346, P=0.032), OA men group (OR=3.200, 95% CI=1.235-7.841, P=0.009), and OA women group (OR=3.444, 95% CI=1.310-6.627, P=0.008). Also, mental problems in the MA men group (OR=2.284, 95% CI=1.591-4.986, P=0.012) and OA men group (OR=1.149, 95% CI=1.017-2.941, P=0.012), and musculoskeletal problems in the MA women group (OR=1.784, 95% CI=1.102-2.902, P=0.021) and OA women group (OR=1.459, 95% CI=1.054-1.993, P=0.004) increased the prevalence.
   Conclusion: The prevalence of MetS due to activity limitation was increased in MA and OA groups. Activity limitation increased the MetS prevalence from 1.4- to 1.5-times, Therefore, to prevent metabolic syndrome, physical activity should be increased, and guidelines should be presented according to the activity limitation causes, age, and sex.
C1 [Lee, Kyujin] Seoul Natl Univ, Inst Sports Sci, Seoul, South Korea.
   [Ko, Duk Han] Dongguk Univ, Dept Sports Sci Convergence, Seoul, South Korea.
   [Lee, Ji Young] Gangneung Wonju Natl Univ, Dept Phys Educ, Kangnung, South Korea.
C3 Seoul National University (SNU); Dongguk University; Gangneung-Wonju
   National University
RP Ko, DH (corresponding author), Dongguk Univ, Dept Sports Sci Convergence, Seoul, South Korea.; Lee, JY (corresponding author), Gangneung Wonju Natl Univ, Dept Phys Educ, Kangnung, South Korea.
EM kodh119@hanmail.net; jylee@gwnu.ac.kr
FU Ministry of Education of the Republic of Korea; National Research
   Foundation of Korea [NRF-2020S1A5A8043065]
FX This work was supported by the Ministry of Education of the Republic of
   Korea and the National Research Foundation of
   Korea(NRF-2020S1A5A8043065).
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NR 47
TC 4
Z9 4
U1 5
U2 15
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-7007
J9 DIABET METAB SYND OB
JI Diabetes Metab. Syndr. Obes.
PY 2020
VL 13
BP 2455
EP 2463
DI 10.2147/DMSO.S257063
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism
GA MK3XH
UT WOS:000548715800001
PM 32765024
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Acosta, D
   Rottbeck, R
   Rodríguez, JG
   González, LM
   Almánzar, MR
   Minaya, SN
   Ortiz, MD
   Ferri, CP
   Prince, MJ
AF Acosta, Daisy
   Rottbeck, Ruth
   Rodriguez, Juana G.
   Gonzalez, Loida M.
   Almanzar, Mary R.
   Minaya, Susana N.
   Ortiz, Maria del C.
   Ferri, Cleusa P.
   Prince, Martin J.
TI The prevalence and social patterning of chronic diseases among older
   people in a population undergoing health transition. A 10/66 Group
   cross-sectional population-based survey in the Dominican Republic
SO BMC PUBLIC HEALTH
LA English
DT Article
ID MIDDLE-INCOME COUNTRIES; RISK-FACTORS; METABOLIC SYNDROME;
   SOCIOECONOMIC-STATUS; NATIONAL-HEALTH; UNITED-STATES; US ADULTS;
   DEMENTIA; TRENDS; EPIDEMIOLOGY
AB Background: Very little of the increased attention towards chronic diseases in countries with low and middle incomes has been directed towards older people, who contribute 72% of all deaths, and 14% of all Disability Adjusted Life Years linked to this group of conditions in those regions. We aimed to study the prevalence of physical, mental and cognitive diseases and impairments among older people in the Dominican Republic, their social patterning, and their relative contributions to disability.
   Methods: A cross-sectional catchment area one-phase survey of chronic disease diagnoses, physical impairments, risk factors and associated disability among 2011 people aged 65 years and over (of whom 1451 gave fasting blood samples) in Santo Domingo, Dominican Republic.
   Results: The most prevalent diagnoses were hypertension (73.0%), anaemia (35.0%), diabetes (17.5%), depression (13.8%) and dementia (11.7%), with 39.6% meeting criteria for metabolic syndrome. After direct standardization (for age and sex) the prevalences of stroke (standardized morbidity ratio [SMR] 100) and hypertension (SMR 108) were similar to those in the United States of America National Health and Nutrition Examination Survey (NHANES reference SMR 100), while those of diabetes (SMR 83) and metabolic syndrome (SMR 72) were somewhat lower. Anaemia was three times more common than in the USA (SMR 310). Diabetes, hypertension, dyslipidaemia, obesity and the metabolic syndrome were associated with affluence and female sex. Arthritis, anaemia, dementia and stroke were strongly age-associated and these conditions were also the main independent contributors to disability.
   Conclusions: The prevalence of many chronic diseases is similar in predominately low socioeconomic status neighbourhoods in the Dominican Republic to that in the USA. Prevalence of age-associated conditions is likely to increase with demographic ageing. There is also scope for increases in cardiovascular disease prevalence, if, as observed in other settings undergoing the epidemiologic transition, the burden of risk factors shifts towards the less affluent. Monitoring future trends in the prevalence and social patterning of chronic diseases may help to assess the effectiveness and equity of primary and secondary prevention strategies. Specific recommendations from our research include identifying and targeting the causes of anaemia among older people, and addressing women's health disadvantages.
C1 [Prince, Martin J.] Inst Psychiat P060, Hlth Serv & Populat Res Dept, London SE5 8AF, England.
   [Acosta, Daisy] Univ Nacl Pedro Henriquez Urena, Geriatr Sect, Dept Internal Med, Santo Domingo, Dominican Rep.
   [Rottbeck, Ruth] Univ Butare, Ctr Hosp, Butare, Rwanda.
   [Rodriguez, Juana G.] Minist Salud Publ & Asistencia, Social Direcc, Area Salud 6, Santo Domingo, Dominican Rep.
   [Gonzalez, Loida M.; Almanzar, Mary R.; Minaya, Susana N.; Ortiz, Maria del C.] Lab Nacl Dr Defillo, Santo Domingo, Dominican Rep.
C3 University of London; King's College London; Universidad Nacional Pedro
   Henriquez Urena
RP Prince, MJ (corresponding author), Inst Psychiat P060, Hlth Serv & Populat Res Dept, De Crespigny Pk, London SE5 8AF, England.
EM martin.prince@kcl.ac.uk
RI Prince, Martin/A-9170-2010; Rodriguez, JUANA/G-3347-2013; ferri,
   cleusa/B-2922-2010
OI Prince, Martin/0000-0003-1379-7146; Rodriguez,
   JUANA/0000-0003-3172-9171; ferri, cleusa/0000-0002-1815-7685
FU Wellcome Trust; World Health Organisation; US Alzheimer's Association
FX The 10/66 Dementia Research Group's research has been funded by the
   Wellcome Trust Health Consequences of Population Change Programme
   (GR066133-Prevalence phase in Cuba and Brazil; GR08002-Incidence phase
   in Peru, Mexico, Argentina, Cuba, Dominican Republic, Venezuela and
   China), the World Health Organisation (India, Dominican Republic and
   China), the US Alzheimer's Association (IIRG-04-1286-Peru, Mexico and
   Argentina), and FONDACIT (Venezuela). The Rockefeller Foundation
   supported our recent dissemination meeting at their Bellagio Centre.
   None of the sponsors or funders of this study had any involvement in
   this publication.
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NR 40
TC 19
Z9 22
U1 1
U2 13
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2458
J9 BMC PUBLIC HEALTH
JI BMC Public Health
PD JUN 16
PY 2010
VL 10
AR 344
DI 10.1186/1471-2458-10-344
PG 17
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA 650KK
UT WOS:000281848000001
PM 20553582
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Yin, HM
   Lu, BL
   Zeng, K
   Li, Y
   Ma, J
AF Yin, Huimin
   Lu, Baili
   Zeng, Kuan
   Li, Yi
   Ma, Jun
TI Prevalence and factors associated with dyslipidemia in patients with
   first hospitalization for major depressive disorder: a large sample
   cross-sectional study
SO BMC PSYCHIATRY
LA English
DT Article
DE Major depressive disorder; Hyperlipidemia; First hospitalization
ID METABOLIC SYNDROME; SERUM-CHOLESTEROL; PATHOPHYSIOLOGY; SYMPTOMS;
   STRESS; PEOPLE
AB Background Major depressive disorder (MDD) is a severe mental illness with high relapse rates and high mortality. Depression not only severely limits psychosocial functioning but also reduces quality of life. It can also negatively affect patients' clinical parameters, including lipid metabolism markers. This study aimed to investigate the prevalence and risk factors of hyperlipidemia (HL) in patients with MDD who were hospitalized for the first time.Methods In this study, we enrolled 981 patients with MDD who were hospitalized for the first time, collected their demographic data and biochemical indicators, and evaluated their clinical symptoms. We divided the patients into HL and non-HL subgroups based on whether they had co-morbid HL. We compared whether there were significant differences between the two groups regarding demographics and general clinical information.Results A total of 708 of 981 MDD patients were described as being in the hyperlipidemic group, with an incidence of 72.17%. Clinical Global Impression Scale-Severity of Illness (CGI-SI) score and Hamilton Depression Scale (HAMD) score are risk factors for co-morbid HL in patients with MDD. The area under the ROC curve for the CGI-SI and HAMD score and their combined discriminatory ability was approximately 63%, 67%, and 68%, respectively.Conclusion The prevalence of HL was high in patients with MDD who were first hospitalized; Higher HAMD score and CGI-SI score were risk factors for the development of HL in MDD; The HAMD score and the CGI-SI score are predictive of the severity of HL.
C1 [Yin, Huimin; Lu, Baili; Zeng, Kuan; Li, Yi] Wuhan Mental Hlth Ctr, Dept Psychiat, 89 Gongnongbing Rd, Wuhan, Hubei, Peoples R China.
   [Ma, Jun] Wuhan Univ, Dept Psychiat, Renmin Hosp, 99 Zhangzhidong Rd, Wuhan, Hubei, Peoples R China.
C3 Wuhan University
RP Li, Y (corresponding author), Wuhan Mental Hlth Ctr, Dept Psychiat, 89 Gongnongbing Rd, Wuhan, Hubei, Peoples R China.; Ma, J (corresponding author), Wuhan Univ, Dept Psychiat, Renmin Hosp, 99 Zhangzhidong Rd, Wuhan, Hubei, Peoples R China.
EM psylee@163.com; majun0313@wo.cn
RI Ma, Jun/HLV-7600-2023
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NR 49
TC 0
Z9 0
U1 2
U2 2
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-244X
J9 BMC PSYCHIATRY
JI BMC Psychiatry
PD MAY 27
PY 2024
VL 24
IS 1
AR 396
DI 10.1186/s12888-024-05848-3
PG 8
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychiatry
GA SE8E8
UT WOS:001232865600002
PM 38802840
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Simoons, M
   Mulder, H
   Doornbos, B
   Schoevers, RA
   van Roon, EN
   Ruhé, HG
AF Simoons, Mirjam
   Mulder, Hans
   Doornbos, Bennard
   Schoevers, Robert A.
   van Roon, Eric N.
   Ruhe, Henricus G.
TI Monitoring of somatic parameters at outpatient departments for mood and
   anxiety disorders
SO PLOS ONE
LA English
DT Article
ID MAJOR DEPRESSIVE DISORDER; METABOLIC SYNDROME; BIPOLAR DISORDER;
   GUIDELINES; RISK; PEOPLE; SCHIZOPHRENIA; RECOMMENDATIONS;
   ANTIPSYCHOTICS; METAANALYSIS
AB Introduction
   Somatic complications account for the majority of the 13-30 years shortened life expectancy in psychiatric patients compared to the general population. The study aim was to assess to which extent patients visiting outpatient departments for mood and anxiety disorders were monitored for relevant somatic comorbidities and (adverse) effects of psychotropic drugs-more specifically a) metabolic parameters, b) lithium safety and c) ECGs-during their treatment.
   Methods
   We performed a retrospective clinical records review and cross-sectional analysis to assess the extent of somatic monitoring at four outpatient departments for mood and anxiety disorders in The Netherlands. We consecutively recruited adult patients visiting a participating outpatient department between March and November 2014. The primary outcome was percentage of patients without monitoring measurements. Secondary outcomes were number of measurements per parameter per patient per year and time from start of treatment to first measurement.
   Results
   We included 324 outpatients, of whom 60.2% were female. Most patients were treated for depressive disorders (39.8%), anxiety disorders (16.7%) or bipolar or related disorders (11.7%) and 198 patients (61.1%) used at least one psychotropic drug. For 186 patients (57.4%), no monitoring records were recorded (median treatment period 7.3 months, range 0-55.6). The median number of measurements per parameter per year since the start of outpatient treatment for patients with monitoring measurements was 0.31 (range 0.0-12.9). The median time to first monitoring measurement per parameter for patients with monitoring measurements was 3.8 months (range 0.0-50.7).
   Discussion
   Somatic monitoring in outpatients with mood and anxiety disorders is not routine clinical practice. Monitoring practices need to be improved to prevent psychiatric outpatients from undetected somatic complications.
C1 [Simoons, Mirjam; Mulder, Hans] Wilhelmina Hosp Assen, Dept Clin Pharm, Assen, Netherlands.
   [Simoons, Mirjam; Schoevers, Robert A.; Ruhe, Henricus G.] Univ Groningen, Univ Med Ctr Groningen, Dept Psychiat, Interdisciplinary Ctr Psychopathol & Emot Regulat, Groningen, Netherlands.
   [Simoons, Mirjam; van Roon, Eric N.] Univ Groningen, Dept Pharmacotherapy Epidemiol & Econ, Dept Pharm, Groningen, Netherlands.
   [Mulder, Hans; Doornbos, Bennard] Mental Hlth Serv Drenthe, Assen, Netherlands.
   [van Roon, Eric N.] Med Ctr Leeuwarden, Dept Clin Pharm & Clin Pharmacol, Leeuwarden, Netherlands.
   [Ruhe, Henricus G.] Univ Oxford, Warneford Hosp, Dept Psychiat, Oxford, England.
C3 University of Groningen; University of Groningen; Medical Center
   Leeuwarden; University of Oxford
RP Mulder, H (corresponding author), Wilhelmina Hosp Assen, Dept Clin Pharm, Assen, Netherlands.; Mulder, H (corresponding author), Mental Hlth Serv Drenthe, Assen, Netherlands.
EM hans.mulder@wza.nl
RI van Roon, Eric/O-2112-2013; Ruhe, Henricus/K-8764-2012
OI Schoevers, Robert A/0000-0003-0760-9866
FU Nederlandse Organisatie voor Wetenschappelijk Onderzoek (NWO)/ZonMW VENI
   [016.126.059]
FX The author(s) received no specific funding for this work, but HGR is
   supported by a Nederlandse Organisatie voor Wetenschappelijk Onderzoek
   (NWO)/ZonMW VENI-Grant (https://www.zonmw.nl/en/research-and-results/
   fundamental-research/programmas/programme-detail/veni/), grant number
   #016.126.059. The funder had no role in study design, data collection
   and analysis, decision to publish, or preparation of the manuscript.
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NR 36
TC 6
Z9 6
U1 0
U2 1
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD AUG 21
PY 2018
VL 13
IS 8
AR e0200520
DI 10.1371/journal.pone.0200520
PG 13
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Science & Technology - Other Topics
GA GR1HU
UT WOS:000442284500002
PM 30130372
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT S
AU Joe, Y
   Zheng, M
   Kim, SK
   Kim, S
   Uddin, JMD
   Min, TS
   Ryu, DG
   Chung, HT
AF Joe, Yeonsoo
   Zheng, Min
   Kim, Seul-Ki
   Kim, Sena
   Uddin, Jamal M. D.
   Min, Tae Sun
   Ryu, Do Gon
   Chung, Hun Taeg
BE Surh, YJ
   Song, YS
   Han, JY
   Jun, TW
   Na, HK
TI The role of carbon monoxide in metabolic disease
SO NUTRITION AND PHYSICAL ACTIVITY IN AGING, OBESITY, AND CANCER
SE Annals of the New York Academy of Sciences
LA English
DT Article; Proceedings Paper
CT 2nd International Conference on Nutrition and Physical Activity in
   Aging, Obesity, and Cancer (NAPA 2011)
CY FEB 16-19, 2010-2011
CL Gyeongju, SOUTH KOREA
DE carbon monoxide; inflammation; ER stress; metabolic disease; heme
   oxygenase-1
ID UNFOLDED-PROTEIN RESPONSE; ENDOPLASMIC-RETICULUM-STRESS; IMPROVES
   INSULIN SENSITIVITY; ENDOTHELIAL-CELL APOPTOSIS; HEME OXYGENASE-1
   INDUCTION; ER STRESS; ACTIVATION; KINASE; INFLAMMATION; EXPRESSION
AB Metabolic disease is a complex disorder defined by various factors that increase the risk of cardiovascular disease and type 2 diabetes mellitus. In recent years, the incidence of chronic metabolic disease has dramatically increased throughout the world. These chronic metabolic diseases are associated with elevated inflammatory activities. In addition, endoplasmic reticulum (ER) stress leads to metabolic syndrome. Inflammation and ER stress are linked in the context of metabolic homeostasis and disease. Carbon monoxide (CO), a reaction product of heme oxygenase-1 (HO-1), reduces oxidative stress and inflammatory response and protects cells from ER stress. CO has anti-inflammatory effects via induction of HO-1 expression and prevents ER stress induced apoptosis by inhibiting the C/EBP homologous protein expression. In addition to its anti-inflammatory effects and antiapoptotic effects, HO-1 plays an important role in insulin release and glucose metabolism. In our study, inhalation of CO gas or CO-releasing molecule injection ameliorates 30% fructose or methionine-deficient- and choline-deficient diet-induced hepatic steatosis. Therefore, CO can be studied in the search for potential therapeutic targets for metabolic diseases via inhibition of inflammatory response and ER stress.
C1 [Joe, Yeonsoo; Kim, Seul-Ki; Kim, Sena; Uddin, Jamal M. D.; Chung, Hun Taeg] Univ Ulsan, Sch Biol Sci, Ulsan 680749, South Korea.
   [Zheng, Min] Univ Ulsan, Dept Med Sci, Ulsan 680749, South Korea.
   [Min, Tae Sun] Natl Res Fdn Korea, Div Nat Sci, Taejon, South Korea.
   [Ryu, Do Gon] Wonkwang Univ, Sch Oriental Med, Dept Physiol, Iksan, Chonbuk, South Korea.
C3 University of Ulsan; University of Ulsan; Wonkwang University
RP Chung, HT (corresponding author), Univ Ulsan, Sch Biol Sci, Bldg 35 Room 806,102 Daehak Ro, Ulsan 680749, South Korea.
EM chung@ulsan.ac.kr
RI Min, Taesun/AEP-1310-2022; Uddin, Md Jamal/W-3434-2017; Kim, You
   Sun/B-2881-2015
OI Uddin, Md Jamal/0000-0003-2911-3255; Kim, Sena/0000-0002-6930-2416
FU Korea Research Foundation; Korean Government (MOEHRD) [BRL-2009-0087350]
FX This work was supported by grants from the Korea Research Foundation
   Grant funded by the Korean Government (MOEHRD) (BRL-2009-0087350).
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NR 41
TC 12
Z9 13
U1 0
U2 4
PU BLACKWELL SCIENCE PUBL
PI OXFORD
PA OSNEY MEAD, OXFORD OX2 0EL, ENGLAND
SN 0077-8923
BN 978-1-57331-842-6
J9 ANN NY ACAD SCI
JI Ann.NY Acad.Sci.
PY 2011
VL 1229
BP 156
EP 161
DI 10.1111/j.1749-6632.2011.06121.x
PG 6
WC Endocrinology & Metabolism; Multidisciplinary Sciences; Nutrition &
   Dietetics
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Science & Technology - Other Topics;
   Nutrition & Dietetics
GA BWJ49
UT WOS:000294027800021
PM 21793851
OA Bronze
DA 2025-06-11
ER

PT J
AU Kaur, P
   Khan, H
   Grewal, AK
   Dua, K
   Singh, SK
   Gupta, G
   Singh, TG
AF Kaur, Parneet
   Khan, Heena
   Grewal, Amarjot Kaur
   Dua, Kamal
   Singh, Sachin Kumar
   Gupta, Gaurav
   Singh, Thakur Gurjeet
TI Exploring Therapeutic Strategies: The Relationship between Metabolic
   Disorders and FOXO Signalling in Alzheimer's Disease
SO CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
LA English
DT Review
DE Alzheimer's disease; FOXO; liver; diabetes; obesity; oxidative stress
ID GLYCOGEN-SYNTHASE KINASE-3; NEUROFIBRILLARY TANGLES; TRANSCRIPTION
   FACTORS; COGNITIVE IMPAIRMENT; INSULIN-RESISTANCE; OXIDATIVE STRESS;
   PPAR-GAMMA; BETA; BRAIN; DROSOPHILA
AB Alzheimer's disease is an ailment that is linked with the degeneration of the brain cells, and this illness is the main cause of dementia. Metabolic stress affects the activity of the brain in AD via FOXO signaling. The occurrence of AD will significantly surge as the world's population ages, along with lifestyle changes perceived in current decades, indicating a main contributor to such augmented prevalence. Similarly, metabolic disorders of current adulthood, such as obesity, stroke, and diabetes mellitus, have been observed as the risk-causing factors of AD. Environmental influences induce genetic mutations that result in the development of several diseases. Metabolic disorders develop when individuals are exposed to an environment where food is easily accessible and requires minimal energy expenditure. Obesity and diabetes are among the most significant worldwide health concerns. Obesity arises because of an imbalance between the amount of energy consumed and the amount of energy expended, which is caused by both behavioral and physiological factors. Obesity, insulin resistance syndrome, hypertension, and inflammation are factors that contribute to the worldwide risk of developing diabetes mellitus and neurodegenerative diseases. FOXO transcription factors are preserved molecules that play an important part in assorted biological progressions, precisely in aging as well as metabolism. Apoptosis, cell division and differentiation, oxidative stress, metabolism, and lifespan are among the physiological processes that the FOXO proteins are adept at controlling. In this review, we explored the correlation between signaling pathways and the cellular functions of FOXO proteins. We have also summarized the intricate role of FOXO in AD, with a focus on metabolic stress, and discussed the prospect of FOXO as a molecular link between AD and metabolic disorders.
C1 [Kaur, Parneet; Khan, Heena; Grewal, Amarjot Kaur; Singh, Thakur Gurjeet] Chitkara Univ, Chitkara Coll Pharm, Patiala 140401, Punjab, India.
   [Dua, Kamal] Univ Technol Sydney, Grad Sch Hlth, Discipline Pharm, Sydney, NSW 2007, Australia.
   [Dua, Kamal] Univ Technol Sydney, Fac Hlth, Australian Res Ctr Complementary & Integrat Med, Ultimo, NSW 2007, Australia.
   [Singh, Sachin Kumar] Lovely Profess Univ, Sch Pharmaceut Sci, Phagwara 144411, Punjab, India.
   [Gupta, Gaurav] Suresh Gyan Vihar Univ, Sch Pharm, Mahal Rd, Jaipur 302017, India.
   [Gupta, Gaurav] Saveetha Univ, Saveetha Inst Med & Tech Sci, Ctr Transdisciplinary Res, Chennai, India.
   [Gupta, Gaurav] Graph Era Hill Univ, Sch Pharm, Dehra Dun 248007, India.
C3 Chitkara University, Punjab; University of Technology Sydney; University
   of Technology Sydney; Lovely Professional University; Saveetha Institute
   of Medical & Technical Science
RP Singh, TG (corresponding author), Chitkara Univ, Chitkara Coll Pharm, Patiala 140401, Punjab, India.
EM Gurjeet.singh@chitkara.edu.in
RI Gupta, Gaurav/AAX-4935-2020; SINGH, SACHIN/I-1948-2019; Khan,
   Heena/AHA-5804-2022; grewal, amarjot/HLQ-4585-2023; Singh, Dr. Thakur
   Gurjeet/AGV-7671-2022
OI Singh, Dr. Thakur Gurjeet/0000-0003-2979-1590
FU Chitkara College of Pharmacy, Chitkara University
FX The authors are grateful to the Chitkara College of Pharmacy, Chitkara
   University, Rajpura, Patiala, Punjab, India, for providing the necessary
   facilities to carry out the research work.
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NR 97
TC 4
Z9 4
U1 3
U2 3
PU BENTHAM SCIENCE PUBL
PI BUSUM
PA PO BOX 294, BUSUM, 1400 AG, NETHERLANDS
SN 1871-5273
EI 1996-3181
J9 CNS NEUROL DISORD-DR
JI CNS Neurol. Disord.-Drug Targets
PY 2025
VL 24
IS 3
BP 196
EP 207
DI 10.2174/0118715273321002240919102841
EA OCT 2024
PG 12
WC Neurosciences; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pharmacology & Pharmacy
GA S3J4C
UT WOS:001345435500001
PM 39473249
DA 2025-06-11
ER

PT J
AU Alagiakrishnan, K
   Halverson, T
AF Alagiakrishnan, Kannayiram
   Halverson, Tyler
TI Role of Peripheral and Central Insulin Resistance in Neuropsychiatric
   Disorders
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Review
DE brain insulin resistance; dementia; depression; exercise; antidiabetic
   drugs
ID BLOOD-BRAIN-BARRIER; COGNITIVE IMPAIRMENT; ALZHEIMERS-DISEASE; METABOLIC
   SYNDROME; GLUCOSE-METABOLISM; INTRANASAL INSULIN; SIGNALING PATHWAYS;
   DIABETIC-PATIENTS; DOUBLE-BLIND; SENSITIVITY
AB Insulin acts on different organs, including the brain, which helps it regulate energy metabolism. Insulin signaling plays an important role in the function of different cell types. In this review, we have summarized the key roles of insulin and insulin receptors in healthy brains and in different brain disorders. Insulin signaling, as well as insulin resistance (IR), is a major contributor in the regulation of mood, behavior, and cognition. Recent evidence showed that both peripheral and central insulin resistance play a role in the pathophysiology, clinical presentation, and management of neuropsychiatric disorders like Cognitive Impairment/Dementia, Depression, and Schizophrenia. Many human studies point out Insulin Resistance/Metabolic Syndrome can increase the risk of dementia especially Alzheimer's dementia (AD). IR has been shown to play a role in AD development but also in its progression. This review article discusses the pathophysiological pathways and mechanisms of insulin resistance in major neuropsychiatric disorders. The extent of insulin resistance can be quantified using IR biomarkers like insulin levels, HOMA-IR index, and Triglyceride glucose-body mass index (TyG-BMI) levels. IR has been shown to precede neurodegeneration. Human trials showed current treatment with certain antidiabetic drugs, as well as life style management, like weight loss and exercise for IR, have shown promise in the management of cognitive/neuropsychiatric disorders. This may pave the pathway to the development of new therapeutic approaches to these challenging disorders of dementia and psychiatric diseases. Recent clinical trials are showing some encouraging evidence for these pharmacological and nonpharmacological approaches for IR in psychiatric and cognitive disorders, even though more research is needed to apply this evidence into clinical practice. Early identification and management of IR may help as a strategy to potentially alter neuropsychiatric disorders onset as well as its progression
C1 [Alagiakrishnan, Kannayiram] Univ Alberta, Dept Med, Edmonton, AB T6G 2R3, Canada.
   [Halverson, Tyler] Univ Toronto, Dept Psychiat, Toronto, ON M5T 1R8, Canada.
C3 University of Alberta; University of Toronto
RP Alagiakrishnan, K (corresponding author), Univ Alberta, Dept Med, Edmonton, AB T6G 2R3, Canada.
EM kalagiakri@aol.com; halverso@ualberta.ca
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NR 144
TC 1
Z9 1
U1 5
U2 6
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD NOV
PY 2024
VL 13
IS 21
AR 6607
DI 10.3390/jcm13216607
PG 19
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA L5Y1P
UT WOS:001351463100001
PM 39518747
OA gold
DA 2025-06-11
ER

PT J
AU Roskar, S
   Zorko, M
   Bucik, V
   Marusic, A
AF Roskar, Saska
   Zorko, Maja
   Bucik, Valentin
   Marusic, Andrej
TI Problem solving for depressed suicide attempters and depressed
   individuals without suicide attempt
SO PSYCHIATRIA DANUBINA
LA English
DT Article
DE metabolic syndrome; schizophrenia; schizoaffective disorder; bipolar
   disorder; major depression; post-traumatic stress syndrome
ID AUTOBIOGRAPHICAL MEMORY; MAJOR DEPRESSION; HOPELESSNESS; DEFICITS;
   IDEATION; REEXAMINATION; BEHAVIOR; FUTURE; RISK
AB Background. Next to feelings of hopelessness, certain cognitive features such as problem solving deficiency, attentional bias and reduced future positive thinking are involved in the development and maintenance of suicidal beahviour. The aim of this study was to examine feelings of hopelessness and problem solving ability in depressed suicide attempters and depressed individuals without a suicide attempt and to see whether these features change over time.
   Method. Three groups of participants, depressed suicide attempters (N=23), psychiatric control group (N=27) and healthy volunteers (N=27) completed measures of hopelessness and executive planning and problem solving abilities. The two clinical groups completed all measures shortly after admission and then again 7 weeks later whereas the non-clinical control group completed meassures at baseline only.
   Results. Both clinical groups displayed a higher level of hopelessness and poorer problem solving ability when compared to non-clinical volunteers. However, no differences were found between the two clinical groups. In neither of the clinical groups was improvement in problem solving ability between baseline and retesting observed despite the lowering of feelings of hopelessness.
   Limitations. The diagnoses in the psychiatric controls group were only obtained by the psychiatrist and not checked by further documentation or questionnaires. Furthermore we did not control for personality traits which might influence cognitive functioning.
   Conclusion. Since feelings of hopelessness decreased over time and problem solving ability nontheless remained stable it is important that treatment not only focuses on mood improvement of depressed suicidal and depressed non-suicidal individuals but also on teaching problem solving techniques.
C1 [Bucik, Valentin] Univ Ljubljana, Dept Psychol, Ljubljana 61000, Slovenia.
   [Marusic, Andrej] Univ Primorska, PINT, Primorska, Slovenia.
C3 University of Ljubljana; University of Primorska
RP Roskar, S (corresponding author), IVZ RS, Trubarjeva 2, Ljubljana 1000, Slovenia.
EM saska.roskar@ivz-rs.si
RI Roskar, Saska/MGA-5097-2025
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NR 28
TC 17
Z9 22
U1 0
U2 16
PU MEDICINSKA NAKLADA
PI ZAGREB
PA VLASKA 69, HR-10000 ZAGREB, CROATIA
SN 0353-5053
J9 PSYCHIAT DANUB
JI Psychiatr. Danub.
PD DEC
PY 2007
VL 19
IS 4
BP 296
EP 302
PG 7
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 272HA
UT WOS:000253849300004
PM 18000480
DA 2025-06-11
ER

PT J
AU Zhang, YX
   Zhang, LF
   Li, ZY
   Liu, XY
   He, PK
   Gu, YY
   Liu, LL
   Jin, Y
   Cheng, SB
   Zhou, FH
   Jia, YH
AF Zhang, Yaxin
   Zhang, Lifang
   Li, Zhaoyong
   Liu, Xiaoyu
   He, Peikun
   Gu, Yuyan
   Liu, Linling
   Jin, Yao
   Cheng, Saibo
   Zhou, Fenghua
   Jia, Yuhua
TI Gualou-Xiebai-Banxia-Tang regulates liver-gut axis to ameliorate
   Metabolic Syndrome in HFD-fed mice
SO PHYTOMEDICINE
LA English
DT Article
DE Metabolic syndrome; Gut microbiota; Liver transcriptomics; TCM;
   Gualou-Xiebai-Banxia-Tang decoction
ID LIPID-METABOLISM; OBESITY; MICROBIOME
AB Background: Metabolic syndrome (MetS), characterized by obesity, hyperglycemia, and abnormal blood lipid levels, is the pathological basis of many cardiovascular diseases. Gualou-Xiebai-Banxia-Tang decoction (GT) was first described in the Synopsis of the Golden Chamber, the earliest traditional Chinese medicine (TCM) monograph on diagnosis and treatment of miscellaneous diseases in China. According to TCM precepts, based on its ability to activate yang to release stagnation, activate qi to reduce depression, remove phlegm, and broaden the chest, GT has been used for more than 2,000 years to treat cardiovascular ailments. However, the molecular bases of its therapeutic mechanisms remain unclear.
   Purpose: The aim of this study was to identify lipid- and glucose-related hepatic genes differentially regulated by GT, and to assess GT impact on gut microbiota composition, in mice with high-fat diet (HFD)-induced MetS.
   Study design and methods: ApoE(-/-) mice were fed with an HFD for 24 weeks, with or without concurrent GT supplementation, to induce MetS. At the study's end, body weight, visceral fat weight, blood lipid levels, and insulin sensitivity were measured, and histopathological staining was used to evaluate hepatosteatosis and intestinal barrier integrity. Liver transcriptomics was used for analysis of differentially expressed genes in liver and prediction of relevant regulatory pathways. Hepatic lipid/glucose metabolism-related genes and proteins were detected by RT-qPCR and western blotting. Gut microbial composition was determined by 16S rRNA gene sequencing.
   Results: GT administration reduced MetS-related liver steatosis and weight gain, promoted insulin sensitivity and lipid metabolism, and beneficially modulated gut microbiota composition by decreasing the relative abundance of g_Lachnospiraceae_NK4A136_group and increasing the relative abundance of g_Alistipes. Liver transcriptomics revealed that GT regulated the expression of genes related to lipid and glucose metabolism (Ppar gamma, Igf1, Gpnmb, and Trem2) and of genes encoding chemokines/chemokine receptors (e.g. Cxcl9 and Cx3cr1). Significant, positive correlations were found for Ccr2, Ccl4, Ccr1, and Cx3cr1 and the g_Lachnospiraceae_NK4A136_group, and between Cxcl9, Ccr2, Ccl4, and Cx3cr1 and g_Desulfovibrio. GT treatment downregulated the protein expressions of SCD1 and CX3CR1 and upregulated the expression of PCK1 protein.
   Conclusion: GT supplementation alleviates HFD-induced MetS in mice by improving hepatic lipid and glucose metabolism. The anti-metabolic syndrome effects of GT may be related to the regulation of the gut-liver axis.
C1 [Zhang, Yaxin; Gu, Yuyan] Southern Med Univ, Sch Tradit Chinese Med, Res Lab State Adm Tradit Chinese Med Level 3, Guangzhou, Guangdong, Peoples R China.
   [Zhang, Lifang; Li, Zhaoyong; He, Peikun; Liu, Linling; Jin, Yao; Cheng, Saibo; Zhou, Fenghua; Jia, Yuhua] Southern Med Univ, Sch Tradit Chinese Med, Guangzhou 510515, Guangdong, Peoples R China.
   [Liu, Xiaoyu] Southern Med Univ, Pingshan Gen Hosp, Shenzhen Pingshan Dist Med Healthcare Grp, Shenzhen, Guangdong, Peoples R China.
C3 Southern Medical University - China; Southern Medical University -
   China; Southern Medical University - China
RP Cheng, SB; Zhou, FH; Jia, YH (corresponding author), Southern Med Univ, Sch Tradit Chinese Med, Guangzhou 510515, Guangdong, Peoples R China.
EM 15013114307@163.com; Wendyzhou515@126.com; yuhuajia_smu@126.com
RI Zhao, Xiaoshan/GPF-7929-2022; Jia, Yu-Hua/D-5097-2012; zhang,
   lifang/ITT-4448-2023; Liu, Xiaoyu/JZD-9005-2024
FU Guangdong natural science foundation project [2021A1515011603,
   2023A1515010451]; Guangdong Basic and Applied Basic Research Fund
   Project [2022A1515111179]; National Natural Science Foundation of China
   [81973802, 82174299]
FX The study was supported by the National Natural Science Foundation of
   China (81973802, 82174299), Guangdong natural science foundation
   <STRONG>project (2021A1515011603, 2023A1515010451) , and Guangdong Basic
   and Applied Basic Research Fund Project (2022A1515111179) .</STRONG>
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NR 38
TC 4
Z9 4
U1 14
U2 27
PU ELSEVIER GMBH
PI MUNICH
PA HACKERBRUCKE 6, 80335 MUNICH, GERMANY
SN 0944-7113
EI 1618-095X
J9 PHYTOMEDICINE
JI Phytomedicine
PD SEP
PY 2024
VL 132
AR 155320
DI 10.1016/j.phymed.2023.155320
EA JUN 2024
PG 13
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA C8E3P
UT WOS:001291642300001
PM 38901285
OA hybrid
DA 2025-06-11
ER

PT J
AU Kamenicky, P
   Houillier, P
   Vantyghem, MC
AF Kamenicky, Peter
   Houillier, Pascal
   Vantyghem, Marie-Christine
TI Chapter 4: Differential diagnosis of primary hyperparathyroidism
SO ANNALES D ENDOCRINOLOGIE
LA English
DT Article
DE Hypercalcemia with low PTH; Hypercalcemia-hypocalciuria; Normo-calcemic
   hyperparathyroidism; Hypophosphatemia; Brown tumor; Osteoarticular pain
ID BONE-RESORPTION; HYPERCALCEMIA; PATIENT; SERIES; GENE
AB The differential diagnosis of primary hyperparathyroidism can be considered clinically, biologically and radiologically. Clinically, primary hyperparathyroidism should be suspected in case of diffuse pain, renal lithiasis, osteoporosis, repeated fracture, cognitive or psychiatric disorder, or disturbance of consciousness. Nevertheless, the differential diagnosis of primary hyperparathyroidism is mainly biological, particularly in atypical forms, which must be differentiated from hypercalcemia with hypocalciuria or non-elevated PTH on the one hand, and from normo-calcemia with elevated PTH, hypophosphatemia or hypercalciuria on the other. Any differential diagnosis must be preceded by an analysis of the factors likely to disturb phospho-calcium parameters: vitamin D deficiency (assay), renal insufficiency (eGFR measurement), malabsorption (inflammatory disease of the digestive tract, celiac disease, bariatric surgery, etc.), insufficient calcium intake (GRIO questionnaire) and iatrogenic causes (diuretics, antiosteoporotic drugs, excessive vitamin D or calcium supplementation, lithium, corticosteroid therapy, phosphorus intake). Once these factors have been eliminated, hypercalcemia with hypocalciuria should suggest a genetic cause. Hypercalcemia with non-elevated PTH may be secondary to neoplasm, hypervitaminosis D (excessive intake, production or catabolism), immobilization or endocrine causes. Elevated PTH values without hypercalcemia must be differentiated from normo-calcemic hyperparathyroidism. High PTH levels are found in PTH-resistant patients, as well as in hypophosphatemic (especially X-linked) or hypercalciuric tubulopathies (certain rare diseases, immobilization, loop diuretics or idiopathic causes favored by a metabolic syndrome). Radiologically, brown tumor must be differentiated primarily from bone metastasis, chondrosarcoma and giant cell tumor. (c) 2025 Published by Elsevier Masson SAS.
C1 [Kamenicky, Peter] Univ Paris Saclay, Serv Endocrinol & Malad Reprod, Ctr Reference Malad Rares Metab Calcium & Phosphat, Hop Bicetre,Assistance Publ Hop Paris,Inserm,Physi, F-94275 Le Kremlin Bicetre, France.
   [Houillier, Pascal] Univ Paris Cite, CNRS Equipe Mixte Rech 8228, Lab Physiol Renale & Tubulopathies, Ctr Rech Cordeliers,Inst Natl Sante & Recherche Me, F-75006 Paris, France.
   [Houillier, Pascal] Hop Europeen Georges Pompidou, Assistance Publ Hop Paris, Serv Physiol, F-75015 Paris, France.
   [Houillier, Pascal] Ctr Reference Malad Rares Calcium & Phosphate, European Reference Network Rare Endocrine Condit E, F-75015 Paris, France.
   [Houillier, Pascal] Univ Paris Cite, Fac Med, F-75006 Paris, France.
   [Vantyghem, Marie-Christine] CHU Lille, Serv Endocrinol Diabetol Metab Nutr, Hop Huriez, 1 Rue Polonovski, F-59037 Lille, France.
   [Vantyghem, Marie-Christine] Univ Lille, Inst Genom European Diabete, Inserm U1190, F-59000 Lille, France.
C3 Universite Paris Saclay; Assistance Publique Hopitaux Paris (APHP);
   Hopital Universitaire Bicetre - APHP; Institut National de la Sante et
   de la Recherche Medicale (Inserm); Universite Paris Cite; Hopital
   Universitaire Saint-Louis - APHP; Hopital Universitaire Antoine-Beclere
   - APHP; Universite Paris Cite; Institut National de la Sante et de la
   Recherche Medicale (Inserm); Sorbonne Universite; Assistance Publique
   Hopitaux Paris (APHP); Universite Paris Cite; Hopital Universitaire
   Europeen Georges-Pompidou - APHP; Hopital Universitaire Saint-Louis -
   APHP; Universite Paris Cite; Universite de Lille; CHU Lille; Institut
   National de la Sante et de la Recherche Medicale (Inserm); Universite de
   Lille
RP Vantyghem, MC (corresponding author), CHU Lille, Endocrinol Diabetol Metab & Nutr, F-59000 Lille, France.
EM mc-vantyghem@chru-lille.fr
RI Kamenicky, Peter/S-4554-2018; VANTYGHEM, Marie/T-8613-2019
OI KAMENICKY, Peter/0000-0002-1994-4226
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NR 75
TC 1
Z9 1
U1 0
U2 0
PU MASSON EDITEUR
PI MOULINEAUX CEDEX 9
PA 21 STREET CAMILLE DESMOULINS, ISSY, 92789 MOULINEAUX CEDEX 9, FRANCE
SN 0003-4266
EI 2213-3941
J9 ANN ENDOCRINOL-PARIS
JI Ann Endocrinol.
PD FEB
PY 2025
VL 86
IS 1
AR 101693
DI 10.1016/j.ando.2025.101693
EA JAN 2025
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA T9E3N
UT WOS:001407947200001
PM 39818292
DA 2025-06-11
ER

PT J
AU Mehta, R
   Birerdinc, A
   Younossi, ZM
AF Mehta, Rohini
   Birerdinc, Aybike
   Younossi, Zobair M.
TI Host Genetic Variants in Obesity-Related Nonalcoholic Fatty Liver
   Disease
SO CLINICS IN LIVER DISEASE
LA English
DT Article
DE SNP; GWAS; Polymorphism; Steatosis
ID TRIGLYCERIDE TRANSFER PROTEIN; NECROSIS-FACTOR-ALPHA; LEPTIN RECEPTOR
   GENE; METABOLIC SYNDROME; PROMOTER POLYMORPHISM; JAPANESE PATIENTS; HFE
   MUTATIONS; UNITED-STATES; HEPATIC IRON; TRANSCRIPTION FACTORS
AB Nonalcoholic fatty liver disease (NAFLD) is a complex disease. The considerable variability in the natural history of the disease suggests an important role for genetic variants in the disease development and progression. There is evidence based on genome-wide association studies and/or candidate gene studies that genetic polymorphisms underlying insulin signaling, lipid metabolism, oxidative stress, fibrogenesis, and inflammation can predispose individuals to NAFLD. This review highlights some of the genetic variants in NAFLD.
C1 [Mehta, Rohini; Birerdinc, Aybike; Younossi, Zobair M.] Inova Hlth Syst, Ctr Liver Dis, Betty & Guy Beatty Ctr Integrated Res, Falls Church, VA 22042 USA.
   [Birerdinc, Aybike] George Mason Univ, Sch Syst Biol, Ctr Study Chron Metab Dis, Fairfax, VA 22030 USA.
   [Younossi, Zobair M.] Inova Fairfax Hosp, Ctr Liver Dis, Dept Med, Falls Church, VA 22042 USA.
C3 Inova Health System; George Mason University; Inova Fairfax Hospital
RP Younossi, ZM (corresponding author), Inova Hlth Syst, Inova Fairfax Hosp, Dept Med, VCU Inova Campus, Falls Church, VA USA.
EM Zobair.Younossi@inova.org
RI Younossi, Zobair M./JRY-9916-2023
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NR 99
TC 9
Z9 10
U1 0
U2 13
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 1089-3261
EI 1557-8224
J9 CLIN LIVER DIS
JI Clin. Liver Dis.
PD FEB
PY 2014
VL 18
IS 1
BP 249
EP +
DI 10.1016/j.cid.2013.09.017
PG 20
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 278VL
UT WOS:000328917900019
PM 24274878
DA 2025-06-11
ER

PT J
AU Wang, Y
   Chen, WJ
   Li, MQ
   Zhou, L
   Jin, YA
   Jin, JZ
   Li, CY
AF Wang, Yan
   Chen, Wen-Jun
   Li, Mei-Qian
   Zhou, Li
   Jin, Ying-Ai
   Jin, Jin-Zhen
   Li, Chun-Yu
TI Nursing Interventions for Patients With Hypertension, Diabetes and
   Dyslipidemia: A Scoping Review
SO JOURNAL OF ADVANCED NURSING
LA English
DT Review; Early Access
DE diabetes; dyslipidemia; hypertension; metabolic syndrome; scoping review
ID HEALTH-CARE; DISEASE; PREVENTION; ADHERENCE
AB AimsTo conduct a comprehensive assessment of nursing interventions for patients with hypertension, diabetes, and dyslipidemia and analyse the components, delivery methods and outcomes of intervention programmes. DesignScoping review. Data SourcesSystematic searches were performed in four Chinese databases (WanFang, CNKI, Chinese Biomedical Literature Database, and the VIP database) and six English databases (CINAHL, MEDLINE, Web of Science, PubMed, Embase, The Cochrane Library) from their inception until October 2023. An updated search was performed on 6 August 2024. MethodsTwo reviewers independently retrieved full-text studies and conducted the initial screening of titles and abstracts, followed by full-text analysis and data extraction. ResultsA total of 49 articles were included in this review. The nursing interventions consisted of various components, including fitness exercise, a balanced diet, mental health support, medication administration and others. The most commonly used delivery method was health education, with an increasing trend towards online interventions. However, the included studies did not provide details on delivery methods, including the team qualifications, subject areas or intervention duration and frequency. The nursing interventions achieved their research aims to varying degrees, as measured by subjective and/or objective indicators. ConclusionThe nursing interventions for the three highs are diverse, including offline, online and combined methods, covering exercise, diet, and mental health. Future efforts can draw on these intervention components and methods and establish a nurse-led multidisciplinary team. The measurement of objective indicators, including blood lipids, should be taken seriously. Developing more diverse subjective measurement indicators can comprehensively assess patients' health. ImpactThis review offers clear guidance for the subsequent prevention and management of the three highs and consolidates evidence for healthcare professionals to devise targeted intervention strategies. Reporting MethodWe followed Arksey's five-step framework and the PRISMA extension for scoping reviews (PRISMA-ScR). Patient or Public ContributionNo.
C1 [Wang, Yan] Yanbian Univ, Sch Med, Yanji, Jilin, Peoples R China.
   [Chen, Wen-Jun] Cent South Univ, Xiangya Sch Nursing, Changsha, Hunan, Peoples R China.
   [Li, Mei-Qian] Shandong Xiandai Univ, Jinan, Shandong, Peoples R China.
   [Zhou, Li] Jiaxing Univ, Sch Med, Jiaxing, Zhejiang, Peoples R China.
   [Jin, Ying-Ai] Yanbian Univ, Dept Nursing, Affiliated Hosp, Yanji, Jilin, Peoples R China.
   [Jin, Jin-Zhen] Yanbian Univ, Yanji, Jilin, Peoples R China.
   [Li, Chun-Yu] Yanbian Univ, Sch Nursing, Yanji, Jilin, Peoples R China.
C3 Yanbian University; Central South University; Jiaxing University;
   Yanbian University; Yanbian University; Yanbian University
RP Li, CY (corresponding author), Yanbian Univ, Sch Nursing, Yanji, Jilin, Peoples R China.
EM 2542223095@qq.com
OI Wang, Yan/0000-0002-7308-8301; li, meiqian/0009-0004-4831-0451
FU Special Project for Promoting the Scientific Research and Innovation
   Capabilities of Doctoral Students (Science and Technology) of the Jilin
   Provincial Department of Education in 2025
FX We express our gratitude to the Special Project for Promoting the
   Scientific Research and Innovation Capabilities of Doctoral Students
   (Science and Technology) of the Jilin Provincial Department of Education
   in 2025 for recognising our research.
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NR 101
TC 0
Z9 0
U1 6
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0309-2402
EI 1365-2648
J9 J ADV NURS
JI J. Adv. Nurs.
PD 2025 MAR 25
PY 2025
DI 10.1111/jan.16889
EA MAR 2025
PG 14
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA 0NJ4S
UT WOS:001451487500001
PM 40130699
DA 2025-06-11
ER

PT J
AU Martínez-Hernández, GB
   Jiménez-Ferrer, E
   González-Cortazar, M
   Alejandro, Z
   Monterrosas-Brisson, N
   Herrera-Ruiz, M
AF Martinez-Hernandez, Gabriela Belen
   Jimenez-Ferrer, Enrique
   Gonzalez-Cortazar, Manases
   Alejandro, Zamilpa
   Monterrosas-Brisson, Nayeli
   Herrera-Ruiz, Maribel
TI Salvia elegans Vahl Counteracting Metabolic Syndrome and
   Depression in Mice on a High-Fat Diet
SO MOLECULES
LA English
DT Article
DE dyslipidemia; obesity; hypertension; central and systemic inflammation;
   inflammatory cytokines; serum corticosterone; sterols; phenolic
   compounds
ID FORCED SWIMMING TEST; ALPHA-D-GLUCOSIDE; HYDROALCOHOLIC EXTRACT;
   INSULIN-RESISTANCE; ROSMARINIC ACID; ADIPOSE-TISSUE; ANTIDEPRESSANT;
   OBESITY; AXIS; INTERLEUKIN-10
AB Salvia elegans Vahl is a plant commonly used in Mexico as a remedy for nervous disorders, inflammatory diseases, and "ringing in the ears"; the latter can be associated with arteriosclerotic conditions and arterial hypertension. Therefore, based on medicinal use, this work aimed to evaluate the hydroalcoholic extract (SeHA, 100 mg/kg) of this plant and two fractions, ethyl acetate (SeFAc, 50 mg/kg), and obtained from SeFAc fractionation denominated SeF3 (10 mg/kg), on several alterations derived from metabolic syndrome (MetS) derived from the ingestion of a high-calorie diet (high-fat diet), in ICR (Institute of Cancer Research) mice, leading to chronic inflammation that results in neurological damage such as depression. Therefore, several MetS-related parameters, such as forced swim tests, hypertension, serum corticosterone levels, glucose, triglycerides, cholesterol, adiposity index, and insulin resistance, will be evaluated. Additionally, tumor necrosis factor (TNF)-alpha, interleukin (IL)-1 beta, IL-6, and IL-10 levels were measured in kidneys, fat tissue, brains, and spleens. It was proven that all those S. elegans-derived treatments reversed the damage, showing antidepressant, antihypertensive, antihyperglycemic, and antidyslipidemic effects and decreased adiposity, insulin resistance, and serum corticosterone. They induced a modulatory response by modifying the levels of TNF-alpha, IL-1 beta, IL-6, and IL-10 in different organs. High-performance liquid chromatography (HPLC) analysis of the acetate of ethyl fraction from S. elegans (SeFAc) fraction revealed the presence of rosmarinic and caffeic acids as well as flavonoids, while the fraction from SeFAc called SeF3 Was identified by gas mass as methyl glucose, glycerol, and known sterols, among others. Thus, it was concluded that S. elegans protects against the harmful effects of MetS.
C1 [Martinez-Hernandez, Gabriela Belen; Jimenez-Ferrer, Enrique; Gonzalez-Cortazar, Manases; Alejandro, Zamilpa; Herrera-Ruiz, Maribel] Inst Mexicano Seguro Social IMSS, Ctr Invest Biomed, Argentina 1, Xochitepec 62790, Mexico.
   [Monterrosas-Brisson, Nayeli] Univ Autonoma Estado Morelos UAEM, Fac Ciencias Biol, Cuernavaca 62209, Morelos, Mexico.
C3 Instituto Mexicano del Seguro Social; Universidad Autonoma del Estado de
   Morelos
RP Herrera-Ruiz, M (corresponding author), Inst Mexicano Seguro Social IMSS, Ctr Invest Biomed, Argentina 1, Xochitepec 62790, Mexico.
EM gabmh89@gmail.com; enriqueferrer_mx@yahoo.com; gmanases@hotmail.com;
   azamilpa_2000@yahoo.com.mx; nayeli.monterrosas@uaem.mx;
   cibis_herj@yahoo.com.mx
RI Zamilpa, Alejandro/AAC-2241-2019; González-Cortazar,
   Manasés/AAL-6644-2020
OI Zamilpa, Alejandro/0000-0002-2233-5958; Gonzalez-Cortazar,
   Manases/0000-0002-3693-1670
FU Fondo de Investigation en Salud-Instituto Mexicano del Seguro Social; 
   [FIS/IMSS/PROT/PRIO/14/029]
FX This work was supported by Fondo de Investigation en Salud-Instituto
   Mexicano del Seguro Social number FIS/IMSS/PROT/PRIO/14/029 (E.J.-F.).
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NR 55
TC 0
Z9 0
U1 3
U2 7
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1420-3049
J9 MOLECULES
JI Molecules
PD SEP
PY 2024
VL 29
IS 17
AR 4070
DI 10.3390/molecules29174070
PG 17
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA F7G9P
UT WOS:001311471900001
PM 39274918
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Dixon, AE
   Holguin, F
AF Dixon, Anne E.
   Holguin, Fernando
TI Diet and Metabolism in the Evolution of Asthma and Obesity
SO CLINICS IN CHEST MEDICINE
LA English
DT Article
DE Diet; Obesity; Asthma; Microbiome; Airway reactivity; Metabolic
   syndrome; Immunometabolism
ID BODY-MASS INDEX; WEIGHT-LOSS; SYSTEMIC INFLAMMATION; AEROBIC EXERCISE;
   LUNG-FUNCTION; AIRWAY INFLAMMATION; INSULIN-RESISTANCE; OXIDATIVE
   STRESS; BARIATRIC SURGERY; GUT MICROBIOTA
AB Obesity is a major risk factor for asthma. This association appears related to altered dietary composition and metabolic factors that can directly affect airway reactivity and airway inflammation. This article discusses how specific changes in the western diet and metabolic changes associated with the obese state affect inflammation and airway reactivity and reviews evidence that interventions targeting weight, dietary components, lifestyle, and metabolism might improve outcomes in asthma.
C1 [Dixon, Anne E.] Univ Vermont, Div Pulm & Crit Care, Given D209,89 Beaumont Ave, Burlington, VT 05482 USA.
   [Holguin, Fernando] Univ Colorado, Dept Med, Div Pulm & Crit Care, Denver, CO 80045 USA.
   [Holguin, Fernando] Allergy & Asthma Clin, Anschutz 1635 Aurora Court,6th Floor, Aurora, CO 80045 USA.
C3 University of Vermont; University of Colorado System; University of
   Colorado Anschutz Medical Campus; University of Colorado Denver
RP Dixon, AE (corresponding author), Univ Vermont, Div Pulm & Crit Care, Given D209,89 Beaumont Ave, Burlington, VT 05482 USA.
EM Anne.dixon@uvmhealth.org
FU NIH [HL133920, HL136917]
FX This article is funded by NIH grants HL133920 and HL136917.
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NR 77
TC 32
Z9 34
U1 1
U2 25
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0272-5231
EI 1557-8216
J9 CLIN CHEST MED
JI Clin. Chest Med.
PD MAR
PY 2019
VL 40
IS 1
BP 97
EP +
DI 10.1016/j.ccm.2018.10.007
PG 11
WC Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Respiratory System
GA HO3WQ
UT WOS:000460854100009
PM 30691720
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Kawashima, M
AF Kawashima, Motoko
TI Systemic Health and Dry Eye
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Article
DE dry eye; systemic health; metabolic syndrome
ID INCREASES TEAR SECRETION; RISK-FACTORS; CALORIE RESTRICTION; METABOLIC
   SYNDROME; OXIDATIVE STRESS; DIETARY SUPPLEMENTATION; NATIONAL-HEALTH;
   OFFICE WORKERS; FISH-OIL; DISEASE
AB Dry eye disease (DED) is a local ocular surface disease caused by a multitude of factors and involves multiple interacting mechanisms. The prevalence of DED is rapidly increasing in the modern aged society, and it is considered a major ocular condition with a high prevalence among the elderly, who frequently have multiple comorbidities. Systemic medical conditions can have a negative impact on ocular health. In addition, a variety of systemic drugs can also induce DED via multiple mechanisms. The adequate management of general systemic diseases may control DED progression. Furthermore, according to the antiaging theory, an appropriate lifestyle intervention is preventive for both DED and general systemic disease. In this article, we focus on systemic health and DED to provide a broad overview of the association between systemic health, particularly in relation to aging, and DED. Ophthalmologists should carefully interview patients with DED regarding systemic comorbidities to deliver optimal treatment. A systemic approach, including the use of supplements and lifestyle intervention, should be used in addition to conventional local treatment.
C1 [Kawashima, Motoko] Keio Univ, Sch Med, Dept Ophthalmol, Tokyo, Japan.
C3 Keio University
RP Kawashima, M (corresponding author), Keio Univ, Sch Med, Dept Ophthalmol, Shinjuku Ku, 35 Shinanomachi, Tokyo 1608582, Japan.
EM motoko-k@a3.keio.jp
FU Dry Eye Society, Tokyo, Japan
FX Funding of the publication fee and administration was provided by the
   Dry Eye Society, Tokyo, Japan. The Dry Eye Society had no role in the
   contents or writing of the manuscript.
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NR 48
TC 22
Z9 23
U1 2
U2 9
PU ASSOC RESEARCH VISION OPHTHALMOLOGY INC
PI ROCKVILLE
PA 12300 TWINBROOK PARKWAY, ROCKVILLE, MD 20852-1606 USA
SN 0146-0404
EI 1552-5783
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD NOV
PY 2018
VL 59
IS 14
SI SI
DI 10.1167/iovs.17-23765
PG 5
WC Ophthalmology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Ophthalmology
GA HC6NV
UT WOS:000451919400021
PM 30481818
OA gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Reid, DT
   Eksteen, B
AF Reid, D. T.
   Eksteen, B.
TI Murine models provide insight to the development of non-alcoholic fatty
   liver disease
SO NUTRITION RESEARCH REVIEWS
LA English
DT Review
DE Obesity; Non-alcoholic fatty liver; Non-alcoholic steatohepatitis;
   Animal models
ID DIET-INDUCED OBESITY; RECEPTOR KNOCKOUT MICE; HEPATIC STEATOSIS;
   INSULIN-RESISTANCE; MOUSE MODEL; METABOLIC SYNDROME; DB/DB MICE;
   HEPATOCELLULAR-CARCINOMA; PARENTERAL-NUTRITION; ANIMAL-MODEL
AB Associated with the obesity epidemic, non-alcoholic fatty liver disease (NAFLD) has become the leading liver disease in North America. Approximately 30 % of patients with NAFLD may develop non-alcoholic steatohepatitis (NASH) that can lead to cirrhosis and hepatocellular carcinoma (HCC). Frequently animal models are used to help identify underlying factors contributing to NAFLD including insulin resistance, dysregulated lipid metabolism and mitochondrial stress. However, studying the inflammatory, progressive nature of NASH in the context of obesity has proven to be a challenge in mice. Although the development of effective treatment strategies for NAFLD and NASH is gaining momentum, the field is hindered by a lack of a concise animal model that reflects the development of liver disease during obesity and the metabolic syndrome. Therefore, selecting an animal model to study NAFLD or NASH must be done carefully to ensure the optimal application. The most widely used animal models have been reviewed highlighting their advantages and disadvantages to studying NAFLD and NASH specifically in the context of obesity.
C1 [Reid, D. T.; Eksteen, B.] Univ Calgary, Cumming Sch Med, Snyder Inst Chron Dis, Calgary, AB, Canada.
C3 University of Calgary
RP Eksteen, B (corresponding author), Univ Calgary, Cumming Sch Med, Snyder Inst Chron Dis, Calgary, AB, Canada.
EM b.eksteen@ucalgary.ca
FU Natural Sciences and Engineering Research Council of Canada (NSERC);
   Canadian Institutes of Health Research (CIHR) Signature Initiative Team
   grant
FX The present review was supported by a Natural Sciences and Engineering
   Research Council of Canada (NSERC) fellowship (to D. T. R.) and a
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NR 98
TC 23
Z9 25
U1 1
U2 34
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0954-4224
EI 1475-2700
J9 NUTR RES REV
JI Nutr. Res. Rev.
PD DEC
PY 2015
VL 28
IS 2
BP 133
EP 142
DI 10.1017/S0954422415000128
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA CY8LH
UT WOS:000366659400004
PM 26494024
OA Bronze
DA 2025-06-11
ER

PT J
AU Huneault, HE
   Tovar, AR
   Sanchez-Torres, C
   Welsh, JA
   Vos, MB
AF Huneault, Helaina E.
   Tovar, Ana Ramirez
   Sanchez-Torres, Cristian
   Welsh, Jean A.
   Vos, Miriam B.
TI The Impact and Burden of Dietary Sugars on the Liver
SO HEPATOLOGY COMMUNICATIONS
LA English
DT Review
ID DE-NOVO LIPOGENESIS; MUSCLE INSULIN-RESISTANCE; FATTY LIVER; HEPATIC
   STEATOSIS; UNITED-STATES; FRUCTOSE RESTRICTION; METABOLIC SYNDROME;
   GENETIC-VARIATION; OXIDATIVE STRESS; LIPID DROPLETS
AB NAFLD, or metabolic dysfunction-associated steatotic liver disease, has increased in prevalence hand in hand with the rise in obesity and increased free sugars in the food supply. The causes of NAFLD are genetic in origin combined with environmental drivers of the disease phenotype. Dietary intake of added sugars has been shown to have a major role in the phenotypic onset and progression of the disease. Simple sugars are key drivers of steatosis, likely through fueling de novo lipogenesis, the conversion of excess carbohydrates into fatty acids, but also appear to upregulate lipogenic metabolism and trigger hyperinsulinemia, another driver. NAFLD carries a clinical burden as it is associated with obesity, type 2 diabetes, metabolic syndrome, and cardiovascular disease. Patient quality of life is also impacted, and there is an enormous economic burden due to healthcare use, which is likely to increase in the coming years. This review aims to discuss the role of dietary sugar in NAFLD pathogenesis, the health and economic burden, and the promising potential of sugar reduction to improve health outcomes for patients with this chronic liver disease.
C1 [Huneault, Helaina E.; Welsh, Jean A.; Vos, Miriam B.] Emory Univ, Laney Grad Sch, Nutr & Hlth Sci Program, Atlanta, GA USA.
   [Tovar, Ana Ramirez; Sanchez-Torres, Cristian; Welsh, Jean A.; Vos, Miriam B.] Emory Univ, Dept Pediat, Div Gastroenterol Hepatol & Nutr, Atlanta, GA USA.
   [Vos, Miriam B.] 1760 Haygood Dr, Atlanta, GA 30030 USA.
C3 Emory University; Emory University
RP Vos, MB (corresponding author), 1760 Haygood Dr, Atlanta, GA 30030 USA.
EM hhuneau@emory.edu; ana.maria.ramirez.tovar@emory.edu;
   cristian.julian.sanchez-torres@emory.edu; jwelsh1@emory.edu;
   mvos@emory.edu
OI Sanchez-Torres, Cristian/0000-0002-0314-5438; Welsh,
   Jean/0000-0002-1372-5524; Ramirez Tovar, Ana/0000-0002-9038-6589;
   Huneault, Helaina/0000-0003-3866-2387
FU National Institutes of Health (NIH) [R01NR019083, R01DK125701]
FX Supported by the National Institutes of Health (NIH) (grant numbers
   R01NR019083 and R01DK125701)
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NR 154
TC 10
Z9 10
U1 2
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
EI 2471-254X
J9 HEPATOL COMMUN
JI Hepatol. Commun.
PD NOV
PY 2023
VL 7
IS 11
AR e0297
DI 10.1097/HC9.0000000000000297
PG 15
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA X2AQ0
UT WOS:001096535400001
PM 37930128
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Nduhirabandi, F
   Maarman, GJ
AF Nduhirabandi, Frederic
   Maarman, Gerald J.
TI Melatonin in Heart Failure: A Promising Therapeutic Strategy?
SO MOLECULES
LA English
DT Review
DE cardiac remodeling; cardioprotection; cardiomyopathy; fibrosis; heart
   failure; hypertension; ischemic heart disease; melatonin; metabolic
   syndrome
ID ISCHEMIA-REPERFUSION INJURY; NOCTURNAL BLOOD-PRESSURE;
   PULMONARY-HYPERTENSION; MYOCARDIAL-INFARCTION; METABOLIC SYNDROME;
   EJECTION FRACTION; RISK-FACTORS; PROTECTS; RATS; ASSOCIATION
AB Heart failure is a multifactorial clinical syndrome characterized by the inability of the heart to pump sufficient blood to the body. Despite recent advances in medical management, poor outcomes in patients with heart failure remain very high. This highlights a need for novel paradigms for effective, preventive and curative strategies. Substantial evidence supports the importance of endogenous melatonin in cardiovascular health and the benefits of melatonin supplementation in various cardiac pathologies and cardiometabolic disorders. Melatonin plays a crucial role in major pathological processes associated with heart failure including ischemic injury, oxidative stress, apoptosis, and cardiac remodeling. In this review, available evidence for the role of melatonin in heart failure is discussed. Current challenges and possible limitations of using melatonin in heart failure are also addressed. While few clinical studies have investigated the role of melatonin in the context of heart failure, current findings from experimental studies support the potential use of melatonin as preventive and adjunctive curative therapy in heart failure.
C1 [Nduhirabandi, Frederic; Maarman, Gerald J.] Univ Cape Town, Fac Hlth Sci, Dept Med, Cardioprotect Grp,HICRA, ZA-7935 Cape Town, South Africa.
C3 University of Cape Town
RP Nduhirabandi, F (corresponding author), Univ Cape Town, Fac Hlth Sci, Dept Med, Cardioprotect Grp,HICRA, ZA-7935 Cape Town, South Africa.
EM frederic.nduhirabandi@uct.ac.za; gmaarman@sun.ac.za
RI Nduhirabandi, Frederic/HTT-5030-2023
OI Maarman, Gerald/0000-0003-3336-5594; Nduhirabandi,
   Frederic/0000-0002-0428-1220
FU South African National Research Foundation (NRF) [99701]; University of
   Cape Town; NRF-Postdoctoral Research Fellowship; European Research
   Council / NRF partnership grant; MDPI
FX This research was funded by the South African National Research
   Foundation (NRF) (99701, FN) and the University of Cape Town. FN
   received an NRF-Postdoctoral Research Fellowship and a European Research
   Council / NRF partnership grant. APC was sponsored by MDPI.
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NR 144
TC 42
Z9 43
U1 1
U2 20
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1420-3049
J9 MOLECULES
JI Molecules
PD JUL
PY 2018
VL 23
IS 7
AR 1819
DI 10.3390/molecules23071819
PG 18
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA GU5CE
UT WOS:000445301800322
PM 30037127
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

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   Maldonade, Iriani Rodrigues
   Pott, Arnildo
   Asato, Marcel Arakaki
   Candido, Camila Jordao
   Avellaneda Guimaraes, Rita de Cassia
TI β-Carotene: Preventive Role for Type 2 Diabetes Mellitus and Obesity: A
   Review
SO MOLECULES
LA English
DT Review
DE oxidative stress; dyslipidemia; antioxidants; insulin resistance
ID METABOLIC SYNDROME; INSULIN-RESISTANCE; SERUM CAROTENOIDS; LOWER
   PREVALENCE; ANTIOXIDANTS; DEGRADATION; CHOLESTEROL; ABSORPTION;
   ADIPOKINES; ADIPOSITY
AB Carotenoids are vital antioxidants for plants and animals. They protect cells from oxidative events and act against the inflammatory process and carcinogenesis. Among the most abundant carotenoids in human and foods is beta-carotene. This carotenoid has the highest level of provitamin A activity, as it splits into two molecules of retinol through the actions of the cytosolic enzymes: beta-carotene-15,15 '-monooxygenase (beta-carotene-15,15 '-oxygenase 1) and beta-carotene-9 ',10 '-dioxygenase (beta-carotene-9 ',10 '-oxygenase 2). The literature supports the idea that beta-carotene acts against type 2 diabetes mellitus, cardiovascular diseases, obesity, and metabolic syndrome. Due to the many processes involved in beta-carotene biosynthesis and metabolic function, little is known about such components, since many mechanisms have not yet been fully elucidated. Therefore, our study concisely described the relationships between the consumption of carotenoids, with emphasis on beta-carotene, and obesity and type 2 diabetes mellitus and its associated parameters in order to understand the preventive role of carotenoids better and encourage their consumption.
C1 [Marcelino, Gabriela; Freitas, Karine de Cassia; Hiane, Priscila Aiko; Candido, Camila Jordao; Avellaneda Guimaraes, Rita de Cassia] Univ Fed Mato Grosso do Sul, Post Grad Program Hlth & Dev Cent West Reg Brazil, BR-79070900 Campo Grande, MS, Brazil.
   [Machate, David Johane] Univ Fed Mato Grosso do Sul, Grad Program Sci Mat, Grp Spect & Bioinformat Appl Biodivers & Hlth GEB, BR-79070900 Campo Grande, MS, Brazil.
   [Maldonade, Iriani Rodrigues] Brazilian Agr Res Corp Embrapa Vegetables, Lab Food Sci & Technol, BR-70275970 Brasilia, DF, Brazil.
   [Pott, Arnildo] Univ Fed Mato Grosso do Sul, Inst Biosci, Lab Bot, BR-79070900 Campo Grande, MS, Brazil.
   [Asato, Marcel Arakaki] Univ Fed Mato Grosso do Sul, Fac Med, BR-79070900 Campo Grande, MS, Brazil.
C3 Universidade Federal de Mato Grosso do Sul; Universidade Federal de Mato
   Grosso do Sul; Empresa Brasileira de Pesquisa Agropecuaria (EMBRAPA);
   Universidade Federal de Mato Grosso do Sul; Universidade Federal de Mato
   Grosso do Sul
RP Freitas, KD (corresponding author), Univ Fed Mato Grosso do Sul, Post Grad Program Hlth & Dev Cent West Reg Brazil, BR-79070900 Campo Grande, MS, Brazil.
EM gabi19ac@gmail.com; machatedavidjohanemachate@yahoo.com.br;
   kcfreitas@gmail.com; priscila.hiane@ufms.br;
   iriani.maldonade@embrapa.br; arnildo.pott@gmail.com;
   marcel_arakakiasato@hotmail.com; cahjordao@gmail.com;
   rita.guimaraes@ufms.br
RI Guimarães, Rita de Cássia/JVO-6281-2024; POTT, ARNILDO/I-5759-2012;
   Johane Machate, David/GPP-1111-2022; Asato, Marcel/AAV-9747-2021;
   Maldonade, Iriani/A-5953-2013
OI Marcelino, Gabriela/0000-0003-0015-6083; Asato,
   Marcel/0000-0002-6050-5292; Maldonade, Iriani/0000-0003-2283-1270
FU Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior, Brazil
   (CAPES) [001]
FX This study was financed in part by the Coordenacao de Aperfeicoamento de
   Pessoal de Nivel Superior, Brazil (CAPES)-Finance Code 001.
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NR 68
TC 73
Z9 75
U1 1
U2 31
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1420-3049
J9 MOLECULES
JI Molecules
PD DEC
PY 2020
VL 25
IS 24
AR 5803
DI 10.3390/molecules25245803
PG 14
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA PL7GV
UT WOS:000603286400001
PM 33316948
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Bartlett, PJ
   Gaspers, LD
   Pierobon, N
   Thomas, AP
AF Bartlett, Paula J.
   Gaspers, Lawrence D.
   Pierobon, Nicola
   Thomas, Andrew P.
TI Calcium-dependent regulation of glucose homeostasis in the liver
SO CELL CALCIUM
LA English
DT Article
DE Calcium; Hepatocyte; Mitochondrial metabolism; Glucose homeostasis; IP3
   receptor; Metabolic syndrome; Liver
ID PROTEIN-KINASE-C; INOSITOL 1,4,5-TRISPHOSPHATE RECEPTORS;
   ENDOPLASMIC-RETICULUM STRESS; CYTOPLASMIC FREE CALCIUM; ISOLATED RAT
   HEPATOCYTES; CA2+ RELEASE CHANNELS; INSULIN-RESISTANCE; GENE-EXPRESSION;
   PERFUSED LIVER; INTACT LIVER
AB A major role of the liver is to integrate multiple signals to maintain normal blood glucose levels. The balance between glucose storage and mobilization is primarily regulated by the counteracting effects of insulin and glucagon. However, numerous signals converge in the liver to ensure energy demand matches the physiological status of the organism. Many circulating hormones regulate glycogenolysis, gluconeogenesis and mitochondrial metabolism by calcium-dependent signaling mechanisms that manifest as cytosolic Ca2+ oscillations. Stimulus-strength is encoded in the Ca2+ oscillation frequency, and also by the range of intercellular Ca2+ wave propagation in the intact liver. In this article, we describe how Ca2+ oscillations and waves can regulate glucose output and oxidative metabolism in the intact liver; how multiple stimuli are decoded though Ca2+ signaling at the organ level, and the implications of Ca2+ signal dysregulation in diseases such as metabolic syndrome and non-alcoholic fatty liver disease. (C) 2014 Published by Elsevier Ltd.
C1 [Bartlett, Paula J.; Gaspers, Lawrence D.; Pierobon, Nicola; Thomas, Andrew P.] Rutgers State Univ, New Jersey Med Sch, Dept Physiol & Pharmacol, Newark, NJ 07102 USA.
C3 Rutgers University System; Rutgers University New Brunswick; Rutgers
   University Biomedical & Health Sciences; Rutgers University Newark
RP Bartlett, PJ (corresponding author), Rutgers State Univ, New Jersey Med Sch, Dept Physiol & Pharmacol, Newark, NJ 07102 USA.
EM paula.bartlett@rutgers.edu
RI Thomas, Andrew/C-6755-2013; Gaspers, Lawrence/W-8766-2019
OI Thomas, Andrew/0000-0002-9026-7467; Gaspers,
   Lawrence/0000-0002-5620-3283
FU NIDDK NIH HHS [R21 DK082954] Funding Source: Medline
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NR 136
TC 69
Z9 75
U1 1
U2 43
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0143-4160
EI 1532-1991
J9 CELL CALCIUM
JI Cell Calcium
PD JUN
PY 2014
VL 55
IS 6
SI SI
BP 306
EP 316
DI 10.1016/j.ceca.2014.02.007
PG 11
WC Cell Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Physiology
GA AK7PA
UT WOS:000338619000005
PM 24630174
DA 2025-06-11
ER

PT J
AU Guimaraes, VHD
   Lelis, DD
   Oliveira, LP
   Borém, LMA
   Guimaraes, FAD
   Farias, LC
   de Paula, AMB
   Guimaraes, ALS
   Santos, SHS
AF Guimaraes, Victor Hugo Dantas
   Lelis, Deborah de Farias
   Oliveira, Luis Paulo
   Borem, Luciana Mendes Araujo
   Guimaraes, Felipe Alberto Dantas
   Farias, Lucyana Conceicao
   de Paula, Alfredo Mauricio Batista
   Guimaraes, Andre Luiz Sena
   Santos, Sergio Henrique Sousa
TI Comparative study of dietary fat: lard and sugar as a better obesity and
   metabolic syndrome mice model
SO ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
LA English
DT Article
DE Animal model; dyslipidemia; oxidative stress; hyperglycaemia; fat liver
ID INSULIN-RESISTANCE; ADIPOSE-TISSUE; ANIMAL-MODELS; HEPATIC STEATOSIS;
   HIGH-CARBOHYDRATE; GENE-EXPRESSION; CAFETERIA DIET; LIVER; ACCUMULATION;
   INFLAMMATION
AB Background
   Diet macronutrient heterogeneity hinders animal studies' data extrapolation from metabolic disorders to human diseases.
   Objective
   The present study aimed to evaluate different fat-diet compositions' effect on inducing lipid/glucose metabolism alterations in mice.
   Methods
   Swiss male mice were fed for 12 weeks with five different diets: Standard Diet (ST), American Institute of Nutrition 93 for growth (AIN93G) high-butter/high-sugar (HBHS), high-lard/high-sugar (HLHS), and high-oil/high-sugar diet (soybean oil) (HOHS). Several parameters, such as serum biochemistry, histology, and liver mRNA expression, were accessed.
   Results
   The main findings revealed that the HLHS diet dramatically altered liver metabolism inducing hepatic steatosis and increased total cholesterol, triglycerides, VLDL, increasing liver CCAAT/enhancer binding protein (CEBP-alpha), Acetyl-CoA carboxylase (ACC) and Catalase (CAT) mRNA expression. Moreover, the HLHS diet increased glucose intolerance and reduced insulin sensitivity.
   Conclusions
   High-fat/high-sugar diets are efficient to induce obesity and metabolic syndrome-associated alterations, and diets enriched with lard and sugar showed more effective results.
C1 [Guimaraes, Victor Hugo Dantas; Lelis, Deborah de Farias; Oliveira, Luis Paulo; Guimaraes, Felipe Alberto Dantas; Farias, Lucyana Conceicao; de Paula, Alfredo Mauricio Batista; Guimaraes, Andre Luiz Sena; Santos, Sergio Henrique Sousa] Univ Estadual Montes Claros Unimontes, Postgrad Program Hlth Sci, Lab Hlth Sci, Montes Claros, MG, Brazil.
   [Borem, Luciana Mendes Araujo] Fac Integradas Pitagoras, Dept Med, Montes Claros, MG, Brazil.
   [Santos, Sergio Henrique Sousa] Univ Fed Minas Gerais UFMG, Postgrad Program Food & Hlth, Inst Agr Sci ICA, Montes Claros, MG, Brazil.
C3 Universidade Estadual de Montes Claros
RP Santos, SHS (corresponding author), Univ Fed Minas Gerais UFMG, Food Engn Coll, Inst Agr Sci, Ave Univ 1000 Univ, BR-39404547 Montes Claros, MG, Brazil.
EM sergiosousas@hotmail.com
RI De Paula, Alfredo/K-3015-2012; Santos, Sergio/GPS-8751-2022; Guimarães,
   Victor/AGJ-6023-2022; Guimaraes, Andre/D-8122-2011
OI Santos, Sergio/0000-0002-7788-5447; De Paula,
   Alfredo/0000-0002-8715-0030; Guimaraes, Victor/0000-0002-4424-8142;
   Guimaraes, Andre/0000-0002-3162-3206
FU Coordenadoria de Aperfeicoamento do Pessoal de Nivel Superior (CAPES);
   Conselho Nacional de Desenvolvimento Cientifico (CNPQ); Fundacao de
   Amparo a Pesquisa do Estado de Minas Gerais (FAPEMIG)
FX This work was supported by the Coordenadoria de Aperfeicoamento do
   Pessoal de Nivel Superior (CAPES) and Conselho Nacional de
   Desenvolvimento Cientifico (CNPQ) and Fundacao de Amparo a Pesquisa do
   Estado de Minas Gerais (FAPEMIG).
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NR 70
TC 19
Z9 19
U1 1
U2 2
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1381-3455
EI 1744-4160
J9 ARCH PHYSIOL BIOCHEM
JI Arch. Physiol. Biochem.
PD MAR 4
PY 2023
VL 129
IS 2
BP 449
EP 459
DI 10.1080/13813455.2020.1835986
EA NOV 2020
PG 11
WC Biochemistry & Molecular Biology; Biophysics; Endocrinology &
   Metabolism; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Endocrinology &
   Metabolism; Physiology
GA A3VJ1
UT WOS:000588511400001
PM 33176505
DA 2025-06-11
ER

PT J
AU Ponziani, FR
   Pecere, S
   Gasbarrini, A
   Ojetti, V
AF Ponziani, Francesca Romana
   Pecere, Silvia
   Gasbarrini, Antonio
   Ojetti, Veronica
TI Physiology and pathophysiology of liver lipid metabolism
SO EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY
LA English
DT Review
DE cardiovascular disease; cholesterol; gut microbiota; liver lipid
   metabolism; metabolic syndrome; NAFLD; NASH
ID TUMOR-NECROSIS-FACTOR; DE-NOVO LIPOGENESIS; ENDOPLASMIC-RETICULUM
   STRESS; NF-KAPPA-B; UNFOLDED PROTEIN RESPONSE; FATTY LIVER;
   INSULIN-RESISTANCE; GENE-EXPRESSION; GUT MICROBIOTA; HEPATIC STEATOSIS
AB Liver lipid metabolism and its modulation are involved in many pathologic conditions, such as obesity, non-alcoholic fatty liver disease, diabetes mellitus, atherosclerosis and cardiovascular disease. Metabolic disorders seem to share a similar background of low-grade chronic inflammation, even if the pathophysiological mechanisms leading to tissue and organ damage have not been completely clarified yet. The accumulation of neutral lipids in the liver is now recognized as a beneficial and protective mechanism; on the other hand, lipoperoxidation is involved in the development and progression of non-alcoholic steatohepatitis. The role of the gut microbiota in liver lipid metabolism has been the object of recent scientific investigations. It is likely that the gut microbiota is involved in a complex metabolic modulation and the translocation of gut microflora may also contribute to maintaining the low-grade inflammatory status of metabolic syndrome. Therefore, lipid metabolism pathology has vague limits and complex mechanisms, and the knowledge of these is essential to guide diagnostic and therapeutic decisions.
C1 [Ponziani, Francesca Romana; Pecere, Silvia; Gasbarrini, Antonio; Ojetti, Veronica] Agostino Gemelli Hosp, Internal Med & Gastroenterol, Rome, Italy.
C3 Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli
RP Pecere, S (corresponding author), Agostino Gemelli Hosp, Internal Med & Gastroenterol, Rome, Italy.
EM silvia.pecere@gmail.com
RI Ojetti, V./AFS-4851-2022; Gasbarrini, Antonio/AAB-8487-2019; pecere,
   silvia/M-2541-2018; Ponziani, Francesca Romana/E-4136-2016
OI pecere, silvia/0000-0002-4401-7344; Ponziani, Francesca
   Romana/0000-0002-5924-6238; Gasbarrini, Antonio/0000-0003-4863-6924;
   Gasbarrini, Antonio/0000-0002-6230-1779
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NR 155
TC 94
Z9 117
U1 1
U2 78
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1747-4124
EI 1747-4132
J9 EXPERT REV GASTROENT
JI Expert Rev. Gastroenterol. Hepatol.
PD AUG
PY 2015
VL 9
IS 8
BP 1055
EP 1067
DI 10.1586/17474124.2015.1056156
PG 13
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA CN2NT
UT WOS:000358259300005
PM 26070860
DA 2025-06-11
ER

PT J
AU De Vogli, R
   Chandola, T
   Marmot, MG
AF De Vogli, Roberto
   Chandola, Tarani
   Marmot, Michael Gideon
TI Negative aspects of close relationships and heart disease
SO ARCHIVES OF INTERNAL MEDICINE
LA English
DT Article
ID SOCIAL SUPPORT; MARITAL QUALITY; CARDIOVASCULAR-DISEASE; METABOLIC
   SYNDROME; FOLLOW-UP; DEPRESSIVE SYMPTOMS; RELATIVE IMPORTANCE;
   WHITEHALL-II; MORTALITY; HEALTH
AB Background: The aims of the study were to (1) analyze the association between negative aspects of close relationships and increased risk for coronary heart disease and (2) examine whether the association is stronger among women and people of lower social position.
   Methods: Prospective cohort study of 9011 British civil servants (6114 men and 2897 women). Negative aspects of close relationships and other social support measures (confiding/emotional and practical) were assessed with the Close Persons Questionnaire during phase 2 (1989-1990) or phase 1 (1985-1988). Associations between negative aspects of close relationships and incident coronary events were determined during an average follow-up period of 12.2 years. Covariates included sociodemographic characteristics (age, sex, marital status, and employment grade), biological factors (obesity, hypertension, diabetes mellitus, and cholesterol level), psychosocial factors (negative affectivity, depression, and work stress), and health behaviors (smoking, alcohol intake, exercise, and fruit and vegetable consumption).
   Results: After adjustment for sociodemographic characteristics, biological factors, and other dimensions of social support, individuals who experienced negative aspects of close relationships had a higher risk of incident coronary events (hazard ratio, 1.34; 95% confidence interval, 1.10-1.63). The association was attenuated but remained statistically significant after additional adjustment for negative affectivity and depression (hazard ratio, 1.25; 95% confidence interval, 1.02-1.55). Although women and men in a lower employment grade were more likely to be exposed to negative aspects of close relationships, sex and social position had no statistically significant interaction effects. Confiding/emotional and practical support were not associated with incident coronary events.
   Conclusion: Adverse close relationships may increase the risk of heart disease.
C1 UCL, Dept Epidemiol & Publ Hlth, Int Inst Soc & Hlth, London WC1E 6BT, England.
C3 University of London; University College London
RP De Vogli, R (corresponding author), UCL, Dept Epidemiol & Publ Hlth, Int Inst Soc & Hlth, 1-19 Torrington Pl, London WC1E 6BT, England.
EM r.devogli@ucl.ac.uk
RI Marmot, Michael/Y-3920-2019; Chandola, Tarani/I-3192-2013
OI Marmot, Michael/0000-0002-2431-6419; Chandola,
   Tarani/0000-0002-1864-3413
FU AHRQ HHS [HS 06516] Funding Source: Medline; British Heart Foundation
   [RG/07/008/23674] Funding Source: Medline; Medical Research Council
   [G19/35, G8802774, G0100222] Funding Source: Medline; NHLBI NIH HHS [HL
   36310] Funding Source: Medline; NIA NIH HHS [AG 13196] Funding Source:
   Medline
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NR 42
TC 126
Z9 160
U1 0
U2 10
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 0003-9926
EI 1538-3679
J9 ARCH INTERN MED
JI Arch. Intern. Med.
PD OCT 8
PY 2007
VL 167
IS 18
BP 1951
EP 1957
DI 10.1001/archinte.167.18.1951
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA 217LC
UT WOS:000249948400005
PM 17923594
DA 2025-06-11
ER

PT J
AU Schmeda-Hirschmann, G
   Antileo-Laurie, J
   Theoduloz, C
   Jiménez-Aspee, F
   Avila, F
   Burgos-Edwards, A
   Olate-Olave, V
AF Schmeda-Hirschmann, Guillermo
   Antileo-Laurie, Javier
   Theoduloz, Cristina
   Jimenez-Aspee, Felipe
   Avila, Felipe
   Burgos-Edwards, Alberto
   Olate-Olave, Veronica
TI Phenolic composition, antioxidant capacity and α-glucosidase inhibitory
   activity of raw and boiled Chilean Araucaria araucana kernels
SO FOOD CHEMISTRY
LA English
DT Article
DE Araucaria araucana; Phenolics; Metabolic syndrome-associated enzymes;
   Antioxidant activity; Mapuche traditional food; HPLC-DAD-QTOF-MSn
AB The Araucaria araucana kernels are a traditional food in southern Chile and Argentina. The aim of this work was to determine the composition of the phenolic-enriched extracts (PEEs) of the boiled kernels as well as their antioxidant capacity, inhibitory activity on metabolic syndrome-associated enzymes and effect on postprandial oxidative stress in a simulated gastric digestion model. The PEEs composition was assessed by HPLC-DAD-MS/ MS. The main PEEs constituents were catechin and epicatechin in the unbound form, while hydroxybenzoic acids occurred mainly in the bound form. The unbound phenolics from boiled kernels showed significant correlations with DPPH, FRAP, TEAC (Pearson's r of 0.481, 0.331 and 0.417, respectively) and lipid peroxidation (r = 0.381) and were more active than the bound phenolics. The extracts were highly active against alpha-glucosidase (IC50: 0.33-3.15 mu g/mL) and reduced lipoperoxidation. Traditional processing increases the flavan-3-ol content. Our results suggest that this traditional food has potential health promoting properties.
C1 [Schmeda-Hirschmann, Guillermo; Antileo-Laurie, Javier; Burgos-Edwards, Alberto] Univ Talca, Inst Quim Recursos Nat, Lab Quim Prod Nat, Campus Lircay, Talca 3460000, Chile.
   [Theoduloz, Cristina] Univ Talca, Fac Ciencias Salud, Lab Cult Celular, Campus Lircay, Talca 3460000, Chile.
   [Jimenez-Aspee, Felipe] Univ Talca, Fac Ciencias Salud, Dept Ciencias Basicas Biomed, Campus Lircay, Talca 3460000, Chile.
   [Avila, Felipe] Univ Talca, Fac Ciencias Salud, Escuela Nutr & Dietet, Campus Lircay, Talca 3460000, Chile.
   [Olate-Olave, Veronica] Fraunhofer Chile Res, Ctr Syst Biotechnol, Ave Condor 844,Piso 3, Santiago, Chile.
   [Jimenez-Aspee, Felipe] Univ Hohenheim, Inst Nutr Sci, Dept Food Biofunctional, D-70599 Stuttgart, Germany.
   [Burgos-Edwards, Alberto] Univ Nacl Asuncion, Fac Ciencias Quim, Dept Fitoquim, Asuncion 1055, Paraguay.
C3 Universidad de Talca; Universidad de Talca; Universidad de Talca;
   Universidad de Talca; Fraunhofer Gesellschaft; Fraunhofer Chile;
   University Hohenheim; Universidad Nacional de Asuncion
RP Schmeda-Hirschmann, G (corresponding author), Univ Talca, Inst Quim Recursos Nat, Lab Quim Prod Nat, Campus Lircay, Talca 3460000, Chile.
EM schmeda@utalca.cl
RI Aspee, Felipe/ABA-2948-2020; Schmeda-Hirschmann, Guillermo/G-1046-2010
OI Burgos-Edwards, Alberto/0000-0001-8286-8556
FU FONDECYT, CORFO Fraunhofer Research Center [1170090]; CORFO FCR
   [CSB-09CEII-6991]; Universidad de Talca; ANID Beca Doctorado Nacional
   Ano Academico 2018 [21180359]; FONDEQUIP EQM [170023]
FX This work was supported by FONDECYT 1170090, CORFO Fraunhofer Research
   Center. Compuestos Bioactivos and CORFO FCR CSB-09CEII-6991; JA-L thanks
   the Universidad de Talca for a Doctoral grant during 2017 and ANID Beca
   Doctorado Nacional Ano Academico 2018 N. 21180359. We are grateful to
   the "Francisco Antileo Cau Cau" Mapuche community (Canete, Chile) for
   their help with the Pino Huacho samples. We thank FONDEQUIP EQM 170023
   for the HPLC-MS/MSn measurements. We thank Mrs. Rachael Jim ' enez-Lange
   (Lexsys Language Consulting, Germany) for the English revision.
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NR 43
TC 15
Z9 15
U1 3
U2 55
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0308-8146
EI 1873-7072
J9 FOOD CHEM
JI Food Chem.
PD JUL 15
PY 2021
VL 350
AR 129241
DI 10.1016/j.foodchem.2021.129241
EA FEB 2021
PG 14
WC Chemistry, Applied; Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Food Science & Technology; Nutrition & Dietetics
GA RB7MZ
UT WOS:000632293600008
PM 33601092
DA 2025-06-11
ER

PT J
AU Liu, JC
   Huang, ZJ
   Ma, WH
   Peng, SX
   Li, YM
   Miranda, KM
   Tian, JD
   Zhang, YH
AF Liu, Jingchao
   Huang, Zhangjian
   Ma, Wenhuan
   Peng, Sixun
   Li, Yunman
   Miranda, Katrina M.
   Tian, Jide
   Zhang, Yihua
TI Design and synthesis of rosiglitazone-ferulic acid-nitric oxide donor
   trihybrids for improving glucose tolerance
SO EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
LA English
DT Article
DE Glucose intolerance; Rosiglitazone; Nitric oxide; Ferulic acid; Type 2
   diabetes mellitus
ID INDUCED INSULIN-RESISTANCE; NECROSIS-FACTOR-ALPHA; HEART-FAILURE;
   L-ARGININE; ANTIHYPERTENSIVE THERAPY; SIGNALING PATHWAYS; TROPONIN
   ELEVATION; OXIDATIVE STRESS; LOWERING DRUGS; BLOOD-PRESSURE
AB Glucose intolerance is associated with metabolic syndrome and type 2 diabetes mellitus (T2DM) while some new therapeutic drugs, such as rosiglitazone (Rosi), for T2DM can cause severe cardiovascular side effects. Herein we report the synthesis of Rosi-ferulic acid (FA)-nitric oxide (NO) donor trihybrids to improve glucose tolerance and minimize the side effects. In comparison with Rosi, the most active compound 21 exhibited better effects on improving glucose tolerance, which was associated with its NO production, antioxidant and anti-inflammatory activities. Furthermore, 21 displayed relatively high stability in the simulated gastrointestinal environments and human liver microsomes, and released Rosi in plasma. More importantly, 21, unlike Rosi, had little stimulatory effect on the membrane translocation of aquaporin-2 (AQP2) in kidney collecting duct epithelial cells. These, together with a better safety profile, suggest that the trihybrids, like 21, may be promising candidates for intervention of glucose intolerance-related metabolic syndrome and T2DM. (C) 2018 Published by Elsevier Masson SAS.
C1 [Liu, Jingchao; Huang, Zhangjian; Peng, Sixun; Zhang, Yihua] China Pharmaceut Univ, State Key Lab Nat Med, Nanjing 210009, Jiangsu, Peoples R China.
   [Liu, Jingchao; Huang, Zhangjian; Peng, Sixun; Zhang, Yihua] China Pharmaceut Univ, Jiangsu Key Lab Drug Discovery Metab Dis, Nanjing 210009, Jiangsu, Peoples R China.
   [Ma, Wenhuan; Li, Yunman] China Pharmaceut Univ, Dept Physiol, State Key Lab Nat Med, Nanjing 210009, Jiangsu, Peoples R China.
   [Miranda, Katrina M.] Univ Arizona, Dept Chem & Biochem, Tucson, AZ 85721 USA.
   [Tian, Jide] Univ Calif Los Angeles, Dept Mol & Med Pharmacol, Los Angeles, CA 90095 USA.
C3 China Pharmaceutical University; China Pharmaceutical University; China
   Pharmaceutical University; University of Arizona; University of
   California System; University of California Los Angeles
RP Zhang, YH (corresponding author), China Pharmaceut Univ, State Key Lab Nat Med, Nanjing 210009, Jiangsu, Peoples R China.; Li, YM (corresponding author), China Pharmaceut Univ, Dept Physiol, State Key Lab Nat Med, Nanjing 210009, Jiangsu, Peoples R China.; Miranda, KM (corresponding author), Univ Arizona, Dept Chem & Biochem, Tucson, AZ 85721 USA.
EM liyunman@cpu.edu.cn; kmiranda@email.arizona.edu; zyhtgd@163.com
RI Miranda, Katrina/B-7823-2009
OI Miranda, Katrina/0000-0002-9175-5091
FU National Natural Science Foundation of China [81822041, 81773573,
   81673305]; Jiangsu Province Funds for Distinguished Young Scientists
   [BK20160033]; Program for New Century Excellent Talents in University
   [NCET-13-1033]; National Institutes of Health [R01-GM076247]
FX This study was supported by grants from the National Natural Science
   Foundation of China (No. 81822041, No. 81773573 and No. 81673305) and
   Jiangsu Province Funds for Distinguished Young Scientists (BK20160033).
   Part of the work was supported by the Program for New Century Excellent
   Talents in University (NCET-13-1033) and the National Institutes of
   Health (R01-GM076247 to K.M.M.).
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NR 78
TC 7
Z9 7
U1 2
U2 41
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0223-5234
EI 1768-3254
J9 EUR J MED CHEM
JI Eur. J. Med. Chem.
PD JAN 15
PY 2019
VL 162
BP 650
EP 665
DI 10.1016/j.ejmech.2018.10.006
PG 16
WC Chemistry, Medicinal
WE Science Citation Index Expanded (SCI-EXPANDED); Index Chemicus (IC)
SC Pharmacology & Pharmacy
GA HI9GE
UT WOS:000456762500045
PM 30481687
DA 2025-06-11
ER

PT J
AU Averna, M
AF Averna, Maurizio
TI The effect of ezetimibe on NAFLD
SO ATHEROSCLEROSIS SUPPLEMENTS
LA English
DT Article
DE Non-alcoholic fatty liver disease; Non-alcoholic steatohepatitis;
   Cholesterol; Ezetimibe
ID FATTY LIVER-DISEASE; NONALCOHOLIC STEATOHEPATITIS; METABOLIC SYNDROME;
   CONTROLLED-TRIAL; EPIDEMIOLOGY; EFFICACY; THERAPY; ADULTS; OBESE; MICE
AB NAFLD has become the most common liver disorder in countries, where obesity, type 2 diabetes mellitus, dyslipidemia, and metabolic syndrome are common. The strong association between these conditions and the risk of cardiovascular disease make treatment crucial. Possible interventions for NAFLD target excess body weight, insulin resistance, inflammation, oxidative stress or intestinal lipid absorption. Administration of combination therapy with a statin plus ezetimibe, associated with lifestyle changes, may represent an effective strategy because of the strong reduction in low-density lipoprotein cholesterol levels. Combination therapy is often more effective, especially when complementary mechanisms of action are involved. Ezetimibe is effective and well tolerated in combination with a number of lipid lowering therapies, including statins, orlistat, and insulin-sensitizing agents. There is strong evidence from preclinical models to supporting the use of ezetimibe in this setting. Larger controlled trials are needed to confirm its effectiveness in patients with NAFLD, to establish the most efficacious combinations and to determine whether treatment can reverse fibrosis. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
C1 Univ Palermo, Sch Med, Dept Internal Med & Med Specialties DIBIMIS, I-90145 Palermo, Italy.
C3 University of Palermo
RP Averna, M (corresponding author), Univ Palermo, Sch Med, Dept Internal Med & Med Specialties DIBIMIS, Via Vespro 141, I-90145 Palermo, Italy.
EM maurizio.averna@unipa.it
RI Averna, Maurizio/U-9527-2017
OI Averna, Maurizio/0000-0003-3558-9209
FU Aegerion; Genzyme; MSD; Roche; Kowa; Amgen; Astra Zeneca; Sanofi; MSD
   Italia Srl
FX Dr. Averna has received payments for the provision of:- Consulting
   services - Aegerion, Genzyme, MSD, Roche, Kowa, Amgen, Astra Zeneca,
   Sanofi.- Participation as a speaker at scientific congresses - Aegerion,
   AstraZeneca, MSD, Mediolanum, Sanofi, Amgen.This work was funded by an
   unrestricted grant by MSD Italia Srl. The sponsor had no role in
   reviewing the literature, drafting or reviewing the paper, or in the
   decision to submit the manuscript for publication. All views expressed
   are solely those of the author. The author would like to thank Editamed
   Srl for editorial assistance in the preparation of the manuscript.
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NR 29
TC 19
Z9 20
U1 0
U2 9
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 1567-5688
EI 1878-5050
J9 ATHEROSCLEROSIS SUPP
JI Atheroscler. Suppl.
PD FEB
PY 2015
VL 17
BP 27
EP 34
PG 8
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA CB4QX
UT WOS:000349614000007
PM 25659874
DA 2025-06-11
ER

PT J
AU Mohyeldin, RH
   Abdelzaher, WY
   Sharata, EE
   Mohamed, HMA
   Ahmed, MYM
   Attia, JZ
   Atta, M
   Saleh, RK
   Ghallab, EA
   Marey, H
   Elrehany, MA
   Rofaeil, RR
AF Mohyeldin, Reham H.
   Abdelzaher, Walaa Yehia
   Sharata, Ehab E.
   Mohamed, Hamza M. A.
   Ahmed, Mohamed Y. M.
   Attia, Josef Zekry
   Atta, Medhat
   Saleh, Rabeh Khairy
   Ghallab, Elshimaa A.
   Marey, Heba
   Elrehany, Mahmoud A.
   Rofaeil, Remon Roshdy
TI Aprepitant boasted a protective effect against olanzapine-induced
   metabolic syndrome and its subsequent hepatic, renal, and ovarian
   dysfunction; Role of IGF1/p-AKT/FOXO1 and NFκB/IL-1β/TNF-α signaling
   pathways in female Wistar albino rats
SO BIOCHEMICAL PHARMACOLOGY
LA English
DT Article
DE MS; Hepatorenal injury; PCOS; Aprepitant; IGF 1; FOXO 1
ID SUBSTANCE-P; INSULIN-RESISTANCE; ATYPICAL ANTIPSYCHOTICS;
   GLUCOSE-METABOLISM; MELATONIN PROTECTS; OXIDATIVE STRESS;
   ADIPOSE-TISSUE; RISK-FACTORS; WEIGHT-GAIN; PHOSPHORYLATION
AB Olanzapine-induced metabolic syndrome (MS) is a primary risk factor for insulin resistance, hepatorenal damage, and polycystic ovarian syndrome. The objective of the current study was to assess the protective effects of aprepitant (AP) against MS caused by olanzapine and the associated ovarian, renal, and liver dysfunction via modulation of IGF1/p-AKT/FOXO1 and NF kappa B/IL-1 beta/TNF-alpha signaling pathways. AP mitigated all biochemical and histopathological abnormalities induced by olanzapine and resulted in a significant reduction of serum HOMAIR, lipid profile parameters, and a substantial decrease in hepatic, renal, and ovarian MDA, IL -6, IL-1 beta, TNF-alpha, NF kappa B, and caspase 3. Serum AST, ALT, urea, creatinine, FSH, LH, and testosterone also decreased significantly by AP administration. The FOXO 1 signaling pathway was downregulated in the AP -treated group, while GSH, SOD, and HDL cholesterol levels were elevated.
C1 [Mohyeldin, Reham H.; Sharata, Ehab E.; Rofaeil, Remon Roshdy] Deraya Univ, Fac Pharm, Dept Pharmacol & Toxicol, Al Minya 61111, Egypt.
   [Abdelzaher, Walaa Yehia; Rofaeil, Remon Roshdy] Minia Univ, Fac Med, Dept Med Pharmacol, Al Minya 61519, Egypt.
   [Mohamed, Hamza M. A.; Ahmed, Mohamed Y. M.] Minia Univ, Fac Med, Dept Obstet & Gynecol, Al Minya 61519, Egypt.
   [Attia, Josef Zekry] Minia Univ, Fac Med, Dept Anesthesia & ICU, Al Minya 61519, Egypt.
   [Atta, Medhat] Minia Univ, Fac Med, Dept Anat, Al Minya 61519, Egypt.
   [Saleh, Rabeh Khairy] Minia Univ, Fac Med, Dept Pathol, Al Minya 61519, Egypt.
   [Ghallab, Elshimaa A.; Elrehany, Mahmoud A.] Deraya Univ, Fac Pharm, Dept Biochem, Al Minya 61111, Egypt.
   [Marey, Heba] Minia Univ, Fac Med, Dept Biochem, Al Minya 61519, Egypt.
C3 Deraya University; Egyptian Knowledge Bank (EKB); Minia University;
   Egyptian Knowledge Bank (EKB); Minia University; Egyptian Knowledge Bank
   (EKB); Minia University; Egyptian Knowledge Bank (EKB); Minia
   University; Egyptian Knowledge Bank (EKB); Minia University; Deraya
   University; Egyptian Knowledge Bank (EKB); Minia University
RP Sharata, EE (corresponding author), Deraya Univ, Fac Pharm, Dept Pharmacol & Toxicol, Al Minya 61111, Egypt.
EM reham.hassan@deraya.edu.eg; walaa.hamada@mu.edu.eg;
   ehab.essam@deraya.edu.eg; Rabeh.Saleh@mu.edu.eg;
   elshimaa.amir@deraya.edu.eg; heba.ebrahim@mu.edu.eg;
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NR 69
TC 7
Z9 7
U1 2
U2 5
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0006-2952
EI 1873-2968
J9 BIOCHEM PHARMACOL
JI Biochem. Pharmacol.
PD MAR
PY 2024
VL 221
AR 116020
DI 10.1016/j.bcp.2024.116020
EA JAN 2024
PG 15
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA MQ5E9
UT WOS:001195099300001
PM 38237301
DA 2025-06-11
ER

PT J
AU Yang, XC
   Bhowmick, K
   Rao, SY
   Xiang, XY
   Ohshiro, K
   Amdur, RL
   Hassan, MI
   Mohammad, T
   Crandall, K
   Cifani, P
   Shetty, K
   Lyons, SK
   Merrill, JR
   Vegesna, AK
   John, S
   Latham, PS
   Crawford, JM
   Mishra, B
   Dasarathy, S
   Wang, XW
   Yu, H
   Wang, ZW
   Huang, H
   Krainer, AR
   Mishra, L
AF Yang, Xiaochun
   Bhowmick, Krishanu
   Rao, Shuyun
   Xiang, Xiyan
   Ohshiro, Kazufumi
   Amdur, Richard L.
   Hassan, Md. Imtaiyaz
   Mohammad, Taj
   Crandall, Keith
   Cifani, Paolo
   Shetty, Kirti
   Lyons, Scott K.
   Merrill, Joseph R.
   Vegesna, Anil K.
   John, Sahara
   Latham, Patricia S.
   Crawford, James M.
   Mishra, Bibhuti
   Dasarathy, Srinivasan
   Wang, Xin Wei
   Yu, Herbert
   Wang, Zhanwei
   Huang, Hai
   Krainer, Adrian R.
   Mishra, Lopa
TI Aldehydes alter TGF-β signaling and induce obesity and cancer
SO CELL REPORTS
LA English
DT Article
ID GROWTH-FACTOR-BETA; METABOLIC SYNDROME; OXIDATIVE STRESS; MECHANISMS;
   BETA-2-SPECTRIN; HYPERTENSION; PATHOGENESIS; INHIBITOR; GENOTYPES;
   PATHWAYS
AB Obesity and fatty liver diseases-metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction-associated steatohepatitis (MASH)-affect over one-third of the global population and are exacerbated in individuals with reduced functional aldehyde dehydrogenase 2 (ALDH2), observed in approximately 560 million people. Current treatment to prevent disease progression to cancer remains inadequate, requiring innovative approaches. We observe that Aldh2-'-- '- and Aldh2-'-Sptbn1+'-- '- Sptbn1 + '- mice develop phenotypes of human metabolic syndrome (MetS) and MASH with accumulation of endogenous aldehydes such as 4-hydroxynonenal (4-HNE). Mechanistic studies demonstrate aberrant transforming growth factor b (TGF-b) signaling through 4-HNE modification of the SMAD3 adaptor SPTBN1 (b2-spectrin) to pro- fibrotic and pro-oncogenic phenotypes, which is restored to normal SMAD3 signaling by targeting SPTBN1 with small interfering RNA (siRNA). Significantly, therapeutic inhibition of SPTBN1 blocks MASH and fibrosis in a human model and, additionally, improves glucose handling in Aldh2-'-- '- and Aldh2-'-Sptbn1+'-- '- Sptbn1 + '- mice. This study identifies SPTBN1 as a critical regulator of the functional phenotype of toxic aldehyde-induced MASH and a potential therapeutic target.
C1 [Yang, Xiaochun; Bhowmick, Krishanu; Xiang, Xiyan; Ohshiro, Kazufumi; Vegesna, Anil K.; John, Sahara; Mishra, Bibhuti; Mishra, Lopa] Inst Bioelect Med, Northwell Hlth, Feinstein Inst Med Res, Dept Med,Div Gastroenterol & Hepatol, Manhasset, NY 11030 USA.
   [Yang, Xiaochun; Bhowmick, Krishanu; Xiang, Xiyan; Cifani, Paolo; Lyons, Scott K.; Merrill, Joseph R.; Vegesna, Anil K.; John, Sahara; Krainer, Adrian R.; Mishra, Lopa] Cold Spring Harbor Lab, Cold Spring Harbor, NY 11724 USA.
   [Rao, Shuyun; Mishra, Lopa] George Washington Univ, Dept Surg, Washington, DC 20037 USA.
   [Amdur, Richard L.] Inst Hlth Syst Sci & Bioelect Med, Northwell Hlth, Feinstein Inst Med Res, Quantitat Intelligence Unit, Manhasset, NY 11030 USA.
   [Hassan, Md. Imtaiyaz; Mohammad, Taj] Jamia Millia Islamia, Ctr Interdisciplinary Res Basic Sci, New Delhi 110025, India.
   [Crandall, Keith] George Washington Univ, Computat Biol Inst, Dept Biostat & Bioinformat, Washington, DC 20037 USA.
   [Shetty, Kirti] Univ Maryland, Sch Med, Dept Gastroenterol & Hepatol, Baltimore, MD 21201 USA.
   [Latham, Patricia S.] George Washington Univ, Dept Pathol, Washington, DC 20037 USA.
   [Crawford, James M.] Northwell Hlth, Donald & Barbara Zucker Sch Med Hofstra, Dept Pathol & Lab Med, Manhasset, NY 11030 USA.
   [Mishra, Bibhuti] Northwell Hlth, Dept Neurol, Manhasset, NY 11030 USA.
   [Dasarathy, Srinivasan] Cleveland Clin, Div Gastroenterol & Hepatol, Cleveland, OH 44106 USA.
   [Wang, Xin Wei] NCI, Ctr Canc Res, Liver Canc Program, Lab Human Carcinogenesis, Bethesda, MD 20892 USA.
   [Yu, Herbert; Wang, Zhanwei] Univ Hawaii Canc Ctr, Epidemiol Program, Honolulu, HI 96813 USA.
   [Huang, Hai] Northwell Hlth, Feinstein Inst Med Res, Ctr Immunol & Inflammat, Donald & Barbara Zucker Sch Med Hofstra, Manhasset, NY 11030 USA.
C3 Northwell Health; Cold Spring Harbor Laboratory; George Washington
   University; Northwell Health; Jamia Millia Islamia; George Washington
   University; University System of Maryland; University of Maryland
   Baltimore; George Washington University; Northwell Health; Northwell
   Health; Cleveland Clinic Foundation; National Institutes of Health (NIH)
   - USA; NIH National Cancer Institute (NCI); Cancer Research Center of
   Hawaii; Northwell Health
RP Mishra, L (corresponding author), Inst Bioelect Med, Northwell Hlth, Feinstein Inst Med Res, Dept Med,Div Gastroenterol & Hepatol, Manhasset, NY 11030 USA.; Mishra, L (corresponding author), Cold Spring Harbor Lab, Cold Spring Harbor, NY 11724 USA.; Mishra, L (corresponding author), George Washington Univ, Dept Surg, Washington, DC 20037 USA.
EM lopamishra2@gmail.com
RI Xiang, Xiyan/GLR-1454-2022; Amdur, Richard/AAE-5345-2019; Crandall,
   Keith/H-2789-2019; Yang, Xiaochun/CAG-2002-2022; Bhowmick,
   Krishanu/CEH-1458-2022; Huang, Hai/F-4286-2012; wang,
   zhanwei/A-3830-2013; Mohammad, Taj/HJH-1874-2023; Wang, Xin
   Wei/B-6162-2009
OI Wang, Xin Wei/0000-0001-9735-606X; Amdur, Richard/0000-0002-4900-653X
FU National Institutes of Health; United States-NIH/NIAAA [R01AA023146];
   NIH/NCI [R01CA236591, U01CA230690]; Elaine H. Snyder Cancer Research
   award
FX We thank Dr. Agata Smogorzewska from Rockefeller University for the
   Aldh2-/-mice. We thank Drs. Zhanhuai Wang, Sobia Zaidi, and Wilma
   Jogunoori for technical support. We thank Dr. Gareth Guenigault's
   support with assays in the 3D human MASH co-culture model. We thank Dr.
   Nancy R. Gough for intellectual input and manuscript editing. This
   research was supported by National Institutes of Health, United
   States-NIH/NIAAA grant R01AA023146 (L.M.) , NIH/NCI grants R01CA236591
   (L.M.) , U01CA230690 (L.M.) , and an Elaine H. Snyder Cancer Research
   award (L.M.) .
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NR 76
TC 4
Z9 4
U1 0
U2 3
PU CELL PRESS
PI CAMBRIDGE
PA 50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA
SN 2211-1247
J9 CELL REP
JI Cell Reports
PD SEP 24
PY 2024
VL 43
IS 9
AR 114676
DI 10.1016/j.celrep.2024.114676
EA AUG 2024
PG 24
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA F0D6M
UT WOS:001306617900001
PM 39217614
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Braescu, L
   Gaspar, M
   Buriman, D
   Aburel, OM
   Merce, AP
   Bratosin, F
   Aleksandrovich, KS
   Alambaram, S
   Mornos, C
AF Braescu, Laurentiu
   Gaspar, Marinica
   Buriman, Darius
   Aburel, Oana Maria
   Merce, Adrian-Petru
   Bratosin, Felix
   Aleksandrovich, Klokov Sergei
   Alambaram, Satish
   Mornos, Cristian
TI The Role and Implications of Epicardial Fat in Coronary Atherosclerotic
   Disease
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Review
DE epicardial fat; atherosclerosis; coronary artery disease; metabolic
   syndrome; oxidative stress
ID PERIVASCULAR ADIPOSE-TISSUE; PERICARDIAL FAT; ARTERY-DISEASE; THICKNESS;
   ASSOCIATION; EXPRESSION; HEART
AB The current minireview aims to assess the implications of epicardial fat secretory function in the development of coronary artery disease. The epicardial adipose tissue (EAT) is a visceral fat depot that has been described as a cardiovascular risk factor. In addition to its mechanical protection role and physiological secretory function, it seems that various secretion products of the epicardial fat are responsible for metabolic disturbances at the level of the cardiac muscle when in association with pre-existing pathological conditions, such as metabolic syndrome. There is a pathological reduction in sarcomere shortening, abnormal cytosolic Ca2+ fluxes, reduced expression of sarcoplasmic endoplasmic reticulum ATPase 2a and decreased insulin-mediated Akt-Ser473-phosphorylation in association with abnormal levels of epicardial fat tissue. Activin A, angiopoietin-2, and CD14-positive monocytes selectively accumulate in the diseased myocardium, resulting in reduced cardiomyocyte contractile function. At the same time, it is believed that these alterations in secretory products directly decrease the myocyte function via molecular changes, thus contributing to the development of coronary disease when certain comorbidities are associated.
C1 [Braescu, Laurentiu; Gaspar, Marinica; Buriman, Darius; Merce, Adrian-Petru] Victor Babes Univ Med & Pharm, Dept Cardiovasc Surg, Timisoara 300041, Romania.
   [Aburel, Oana Maria] Victor Babes Univ Med & Pharm, Dept Funct Sci Pathophysiol, Fac Med, Timisoara 300041, Romania.
   [Aburel, Oana Maria] Victor Babes Univ Med & Pharm, Ctr Translat Res & Syst Med, Timisoara 300041, Romania.
   [Bratosin, Felix] Victor Babes Univ Med & Pharm, Dept Infect Dis, Methodol & Infect Dis Res Ctr, Timisoara 300041, Romania.
   [Aleksandrovich, Klokov Sergei] NV Sklifosovsky Res Inst Emergency Med, Bolshaya Sukharevskaya Ploshchad 3, Moscow 129090, Russia.
   [Alambaram, Satish] Bhaskar Med Coll, Amdapur Rd 156-162, Hyderabad 500075, India.
   [Mornos, Cristian] Victor Babes Univ Med & Pharm, Discipline Cardiol, Eftimie Murgu Sq 2, Timisoara 300041, Romania.
C3 Victor Babes University of Medicine & Pharmacy, Timisoara; Victor Babes
   University of Medicine & Pharmacy, Timisoara; Victor Babes University of
   Medicine & Pharmacy, Timisoara; Victor Babes University of Medicine &
   Pharmacy, Timisoara; Victor Babes University of Medicine & Pharmacy,
   Timisoara
RP Aburel, OM (corresponding author), Victor Babes Univ Med & Pharm, Dept Funct Sci Pathophysiol, Fac Med, Timisoara 300041, Romania.; Aburel, OM (corresponding author), Victor Babes Univ Med & Pharm, Ctr Translat Res & Syst Med, Timisoara 300041, Romania.
EM oanaduicu@umft.ro
RI Braescu, Laurentiu/HZK-8517-2023; Mornoş, Cristian/AHC-6893-2022;
   Bratosin, Felix/HDN-8724-2022; Buriman, Darius/KVB-8099-2024; Aburel,
   Oana/I-7658-2016
OI Braescu, Laurentiu/0000-0002-1658-7526; Bratosin,
   Felix/0000-0003-4711-4315; Buriman, Darius/0009-0005-3752-2122
FU Victor Babes University of Medicine and Pharmacy Grant
   [MITO-MB-CURAT:2POSTDOC/1387/03.02.2020]
FX Research supported by Victor Babes University of Medicine and Pharmacy
   Grant MITO-MB-CURAT:2POSTDOC/1387/03.02.2020.
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NR 44
TC 15
Z9 15
U1 2
U2 11
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD AUG
PY 2022
VL 11
IS 16
AR 4718
DI 10.3390/jcm11164718
PG 9
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 4B2WQ
UT WOS:000845644900001
PM 36012956
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Mauro, C
   De Rosa, V
   Marelli-Berg, F
   Solito, E
AF Mauro, Claudio
   De Rosa, Veronica
   Marelli-Berg, Federica
   Solito, Egle
TI Metabolic syndrome and the immunological affair with the blood-brain
   barrier
SO FRONTIERS IN IMMUNOLOGY
LA English
DT Review
DE blood-brain barrier; metabolism; immune response; leukocytes; diet
ID ADVANCE TRANSLATIONAL RESEARCH; IMMUNE SURVEILLANCE; CALORIC
   RESTRICTION; T-CELLS; LEPTIN; OBESITY; CNS; ACTIVATION; HEALTH;
   NEUROINFLAMMATION
AB Epidemiological studies reveal an increased incidence of obesity world wide, which is associated with increased prevalence and severity of cognitive disorders. The blood-brain barrier (BBB) represents the interface between the peripheral circulation and the brain, and plays a fundamental role in the crosstalk between these two compartments. The homeostatic function of the BBB is the protection of the brain from peripheral insult/inflammation. Alterations in the function of the BBB lead to pathologies of the central nervous system. Recently, metabolic imbalance has been shown to be an important risk factor associated with the decline of BBB integrity and function. This has direct etiological consequences on a variety of cerebrovascular and neurodegenerative pathologies with great impact to society. Priority areas for future preclinical research include strategies to improve clinicians' ability to diagnose, prevent, and manage BBB abnormalities. In sharp contrast with epidemiological studies and clinical needs, little is known about the mechanisms that link metabolic syndrome to BBB functionality and cognitive disorders. Our view is that immune responses caused by metabolic stress might play a major role in this conundrum.
C1 [Mauro, Claudio; Marelli-Berg, Federica; Solito, Egle] Queen Mary Univ London, Barts & London Sch Med & Dent, William Harvey Res Inst, London EC1M 6BQ, England.
   [De Rosa, Veronica] CNR, IEOS, Ist Endocrinol & Oncol Sperimentale G Salvatore, I-80125 Naples, Italy.
C3 University of London; Queen Mary University London; Consiglio Nazionale
   delle Ricerche (CNR); Istituto per Endocrinologia e Oncologia "Gaetano
   Salvatore" (IEOS-CNR)
RP Solito, E (corresponding author), Queen Mary Univ London, Barts & London Sch Med & Dent, Ctr Translat Med & Therapeut, William Harvey Res Inst, John Vane Bldg,Charterhouse Sq, London EC1M 6BQ, England.
EM e.solito@qmul.ac.uk
RI ; De Rosa, Veronica/K-6534-2016; Mauro, Claudio/AAN-1848-2021
OI Solito, Egle/0000-0001-5279-0049; De Rosa, Veronica/0000-0002-9477-0991;
   Mauro, Claudio/0000-0002-3736-0099
FU British Heart Foundation [FS/12/38/29640]; Ministero della Salute
   [GR-2010-2315414]; FIRB grant [RBFR12I3UB-004]; BHF Programme
   [RG/14/2/30616]; ARUK grant [PPG2013B-2]; Wellcome Trust [085123]
FX The authors are grateful to their respective sponsors for their support:
   the British Heart Foundation Fellowship FS/12/38/29640 to Claudio Mauro;
   Ministero della Salute grant GR-2010-2315414 and FIRB grant
   RBFR12I3UB-004 to Veronica De Rosa; BHF Programme grant RG/14/2/30616 to
   Federica Marelli-Berg; ARUK grant PPG2013B-2 and Wellcome Trust grant
   085123 to Egle Solito.
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NR 61
TC 30
Z9 30
U1 0
U2 6
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-3224
J9 FRONT IMMUNOL
JI Front. Immunol.
PD JAN 5
PY 2015
VL 5
BP 1
EP 6
AR 677
DI 10.3389/fimmu.2014.00677
PG 6
WC Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology
GA CI2TC
UT WOS:000354598900001
PM 25601869
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Kawai, H
   Kurata, T
   Deguchi, K
   Deguchi, S
   Yamashita, T
   Ohta, Y
   Omote, Y
   Kono, S
   Abe, K
AF Kawai, Hiromi
   Kurata, Tomoko
   Deguchi, Kentaro
   Deguchi, Shoko
   Yamashita, Toru
   Ohta, Yasuyuki
   Omote, Yoshio
   Kono, Syoichiro
   Abe, Koji
TI Combination benefit of amlodipine plus atorvastatin treatment on carotid
   atherosclerosis in Zucker metabolic rats
SO NEUROLOGICAL RESEARCH
LA English
DT Article
DE Amlodipine; Atorvastatin; Common carotid artery; Zucker fatty rat
ID MONOCYTE CHEMOATTRACTANT PROTEIN-1; SPONTANEOUSLY HYPERTENSIVE-RATS;
   SMOOTH-MUSCLE-CELLS; INSULIN-RESISTANCE; OXIDATIVE STRESS; DEFICIENT
   MICE; BLOOD-PRESSURE; UP-REGULATION; SIRT1; RECEPTOR
AB Objectives: Obesity is the major risk factor for metabolic syndrome and atherosclerotic cardiocerebrovascular diseases.
   Methods: We studied effects of amlodipine, atorvastatin, and their combination on carotid arteriosclerotic processes in a metabolic syndrome model of Zucker fatty rats. Zucker fatty rats were treated with vehicle, amlodipine, atorvastatin, or combination amlodipine plus atorvastatin for 28 days.
   Results: Compared with the single treatment with amlodipine or atorvastatin, the combination of amlodipine plus atorvastatin treatment prevented arteriosclerotic processes, and induced a strong recovery of Sirtuin1 (Sirt1) expression and a marked reduction in p53, p21, and monocyte chemoattractant protein-1 (MCP-1).
   Discussion: As Sirt1 is a longevity gene that prevents endothelial atherosclerotic processes, and p53, p21, and MCP-1 play pivotal roles in the initiation and development of atherosclerosis, these data suggest a strong synergistic benefit of combination therapy with amlodipine and atorvastatin for preventing atherosclerotic processes, and potentially reducing the clinical risk of cerebrovascular events in metabolic obesity patients.
C1 [Kawai, Hiromi; Kurata, Tomoko; Deguchi, Kentaro; Deguchi, Shoko; Yamashita, Toru; Ohta, Yasuyuki; Omote, Yoshio; Kono, Syoichiro; Abe, Koji] Okayama Univ, Dept Neurol, Grad Sch Med Dent & Pharmaceut Sci, Okayama 7008558, Japan.
C3 Okayama University
RP Abe, K (corresponding author), Okayama Univ, Dept Neurol, Grad Sch Med Dent & Pharmaceut Sci, 2-5-1 Shikatacho, Okayama 7008558, Japan.
EM toko11@cc.okayama-u.ac.jp
OI Yamashita, Toru/0000-0003-3634-5679
FU Ministry of Education, Science, Culture and Sports of Japan; Research
   Committee of CNS Degenerative Diseases; Ministry of Health, Labour and
   Welfare of Japan;  [21390267]
FX This study was supported in part by a Grant-in-Aid for Scientific
   Research (B) 21390267 and the Ministry of Education, Science, Culture
   and Sports of Japan, by Grants-in-Aid from the Research Committee of CNS
   Degenerative Diseases (Nakano I), and by grants (Mizusawa H, Nishizawa
   M, Sasaki H, Sobue G) from the Ministry of Health, Labour and Welfare of
   Japan.
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NR 47
TC 5
Z9 5
U1 0
U2 7
PU MANEY PUBLISHING
PI LEEDS
PA STE 1C, JOSEPHS WELL, HANOVER WALK, LEEDS LS3 1AB, W YORKS, ENGLAND
SN 0161-6412
J9 NEUROL RES
JI Neurol. Res.
PD MAR
PY 2013
VL 35
IS 2
BP 181
EP 186
DI 10.1179/1743132812Y.0000000131
PG 6
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 101KL
UT WOS:000315773800015
PM 23336931
DA 2025-06-11
ER

PT J
AU Hernández-Pérez, S
   Oliart-Ros, RM
   Casas-Godoy, L
   Sandoval, G
   Guarner-Lans, V
   Castrejón-Téllez, V
   Quevedo-Corona, L
   Peña-Montes, C
   Ramirez-Higuera, A
AF Hernandez-Perez, Susana
   Oliart-Ros, Rosa Maria
   Casas-Godoy, Leticia
   Sandoval, Georgina
   Guarner-Lans, Veronica
   Castrejon-Tellez, Vicente
   Quevedo-Corona, Lucia
   Pena-Montes, Carolina
   Ramirez-Higuera, Abril
TI Beneficial Effects of Fructooligosaccharides Esterified with Lauric Acid
   in a Metabolic Syndrome Model Induced by a High-Fat and
   High-Carbohydrate Diet in Wistar Rats
SO JOURNAL OF MEDICINAL FOOD
LA English
DT Article
DE Agave; fructooligosaccharides; high-fat high-carbohydrate diet; lauric
   acid; prebiotics
ID AGAVE-TEQUILANA FRUCTANS; SUCROSE; OBESITY; WEIGHT
AB Metabolic syndrome (MS) is a group of abnormalities in which obesity, insulin resistance (IR), oxidative stress, and dyslipidemia stand out. This pathology predisposes to the development of cardiovascular diseases and diabetes. The ingestion of linear fructooligosaccharides (FOS) such as inulin reduces conditions such as hyperinsulinemia, increased body fat, and triglyceridemia. When FOS are esterified with fatty acids, they present emulsifying and surfactant properties; however, there are no reports of their function at the biological level. The purpose of this investigation was to evaluate the effect of Agave tequilana Weber's FOS (AtW-FOS) and FOS esterified with lauric acid (FOS-LA) in MS markers in a rat model induced by a HFHC diet. Supplementation with AtW-FOS and FOS-LA decreased IR, improved glucose tolerance, reduced liver weight (19%), plasma triglycerides (24%), and blood pressure (16%) when compared with the untreated MS group. In conclusion, the ingestion of AtW-FOS and FOS-LA has beneficial effects in the prevention of MS alterations, showing a high potential for their application in functional foods.
C1 [Hernandez-Perez, Susana; Oliart-Ros, Rosa Maria; Pena-Montes, Carolina; Ramirez-Higuera, Abril] Natl Tech Mexico Tecnol Nacl Mexico IT Veracruz, Res & Food Dev Unit UNIDA, Veracruz, Mexico.
   [Casas-Godoy, Leticia] CONACYT Ctr Res & Asistance Technol & Design Jali, Ind Biotechnol Unit, Zapopan, Jalisco, Mexico.
   [Sandoval, Georgina] Ctr Res & Asistance Technol & Design Jalisco Stat, Ind Biotechnol Unit, Guadalajara, Jalisco, Mexico.
   [Guarner-Lans, Veronica; Castrejon-Tellez, Vicente] Natl Inst Cardiol Ignacio Chavez, Dept Physiol, Mexico City, Mexico.
   [Quevedo-Corona, Lucia] Natl Polytech Inst IPN, Natl Sch Biol Sci ENCB, Dept Physiol, Mexico City, Mexico.
C3 National Institute of Cardiology - Mexico; Instituto Politecnico
   Nacional - Mexico
RP Ramirez-Higuera, A (corresponding author), Nacl Mexico IT Veracruz, Miguel Angel Quevedo 2779, Veracruz, Mexico.
EM abrilhiguera@hotmail.com
RI Sandoval, Georgina/ABB-8999-2020; V, Guarner/AFW-2513-2022; Peña-Montes,
   Carolina/AAD-1192-2021; Oliart-Ros, Rosamaria/AAS-5105-2021;
   Casas-Godoy, Leticia/G-2818-2019; Sandoval, Georgina/C-3327-2008
OI Casas-Godoy, Leticia/0000-0002-0566-5824; Sandoval,
   Georgina/0000-0002-9105-0702; Ramirez Higuera,
   Abril/0000-0002-1430-2689; Pena-Montes, Carolina/0000-0002-4767-1210
FU Consejo Nacional de Ciencia y Tecnologia
FX The financial support provided by Consejo Nacional de Ciencia y
   Tecnologia for Susana Hernandez-Perez master fellowship.
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NR 29
TC 9
Z9 9
U1 2
U2 11
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1096-620X
EI 1557-7600
J9 J MED FOOD
JI J. Med. Food
PD AUG 1
PY 2022
VL 25
IS 8
BP 828
EP 835
DI 10.1089/jmf.2021.0109
EA APR 2022
PG 8
WC Chemistry, Medicinal; Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Food Science & Technology; Nutrition &
   Dietetics
GA 3V3KA
UT WOS:000782512600001
PM 35394894
DA 2025-06-11
ER

PT J
AU Rupp, H
   Maisch, B
AF Rupp, H
   Maisch, B
TI Abdominal fat and sympathetic overactivity
SO HERZ
LA English
DT Article
DE hypertension; sympathoadrenergic stimulation; central obesity
ID ANGIOTENSIN-II FORMATION; VISCERAL ADIPOSE-TISSUE; INSULIN-RESISTANCE;
   SYSTOLIC HYPERTENSION; METABOLIC SYNDROME; BODY-COMPOSITION; NERVE
   ACTIVITY; ACTIVATION; STRESS; RISK
AB Background: Epidemiologic studies have found an association between overweight and increased mortality arising primarily from cardiovascular disorders. A major determinant is a chronically raised sympathetic nervous system activity which can arise from calorie intake-dependent and -independent mechanisms. Calorie-dependent parameters reflecting sympathetic overactivity are an increased body fat mass and body mass index.
   Visceral Fat: Although influenced by calorie intake to a certain extent, visceral fat accumulation is a mechanism which is determined also by estrogen deficiency (postmenopausal hypertension) or enhanced corticoid influences. It is hypothesized that excess catecholamines trigger various adverse processes which, if they persist, can lead or aggravate hypertension and insulin resistance. Visceral but not peripheral fat mass was correlated with atherogenic metabolites.
   Excess Catecholamine Syndrome: The present focus on visceral fat accumulation strengthens the concept of an "excess catecholamine syndrome" of which the "metabolic syndrome" appears as one consequence. It is proposed to further assess the potential of transthoracic echocardiography as routine imaging method for the prediction of visceral fat accumulation and its adverse health consequences.
C1 Univ Marburg, Mol Cardiol Lab, Dept Internal Med & Cardiol, D-35033 Marburg, Germany.
C3 Philipps University Marburg
RP Univ Marburg, Mol Cardiol Lab, Dept Internal Med & Cardiol, Karl Von Frisch Str 1, D-35033 Marburg, Germany.
EM Rupp@staff.uni-marburg.de
RI Maisch, Bernhard/AAH-9198-2020
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NR 45
TC 8
Z9 10
U1 0
U2 3
PU URBAN & VOGEL
PI MUNICH
PA NEUMARKTER STRASSE 43, D-81673 MUNICH, GERMANY
SN 0340-9937
EI 1615-6692
J9 HERZ
JI Herz
PD DEC
PY 2003
VL 28
IS 8
BP 668
EP 673
DI 10.1007/s00059-003-2517-5
PG 6
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 761TZ
UT WOS:000187932700004
PM 14689100
DA 2025-06-11
ER

PT J
AU Vigod, SN
   Ray, JG
   Cohen, E
   Wilton, AS
   Saunders, NR
   Barker, LC
   Berard, A
   Dennis, CL
   Holloway, AC
   Morrison, K
   Oberlander, TF
   Hanley, G
   Tu, K
   Brown, HK
AF Vigod, Simone N.
   Ray, Joel G.
   Cohen, Eyal
   Wilton, Andrew S.
   Saunders, Natasha R.
   Barker, Lucy C.
   Berard, Anick
   Dennis, Cindy-Lee
   Holloway, Alison C.
   Morrison, Katherine
   Oberlander, Tim F.
   Hanley, Gillian
   Tu, Karen
   Brown, Hilary K.
TI Maternal Schizophrenia and the Risk of a Childhood Chronic Condition
SO SCHIZOPHRENIA BULLETIN
LA English
DT Article
DE Schizophrenia; Pregnancy; Child Health
ID SERIOUS MENTAL-ILLNESS; DEVELOPMENTAL ORIGINS; METABOLIC SYNDROME;
   DIABETES-MELLITUS; SEX-DIFFERENCES; WOMEN; HEALTH; CARE; DISORDERS;
   MOTHERS
AB Background and Hypothesis Maternal schizophrenia heightens the risk for certain perinatal complications, yet it is not known to what degree future childhood chronic health conditions (Childhood-CC) might arise. Study Design This population-based cohort study using health administrative data from Ontario, Canada (1995-2018) compared 5066 children of mothers with schizophrenia to 25 324 children of mothers without schizophrenia, propensity-matched on birth-year, maternal age, parity, immigrant status, income, region of residence, and maternal medical and psychiatric conditions other than schizophrenia. Cox proportional hazard models generated hazard ratios (HR) and 95% confidence intervals (CI) for incident Childhood-CCs, and all-cause mortality, up to age 19 years. Study Results Six hundred and fifty-six children exposed to maternal schizophrenia developed a Childhood-CC (20.5/1000 person-years) vs. 2872 unexposed children (17.1/1000 person-years)-an HR of 1.18, 95% CI 1.08-1.28. Corresponding rates were 3.3 vs. 1.9/1000 person-years (1.77, 1.44-2.18) for mental health Childhood-CC, and 18.0 vs. 15.7/1000 person-years (1.13, 1.04-1.24) for non-mental health Childhood-CC. All-cause mortality rates were 1.2 vs. 0.8/1000 person-years (1.34, 0.96-1.89). Risk for children exposed to maternal schizophrenia was similar whether or not children were discharged to social service care. From age 1 year, risk was greater for children whose mothers were diagnosed with schizophrenia prior to pregnancy than for children whose mothers were diagnosed with schizophrenia postnatally. Conclusions A child exposed to maternal schizophrenia is at elevated risk of chronic health conditions including mental and physical subtypes. Future research should examine what explains the increased risk particularly for physical health conditions, and what preventive and treatment efforts are needed for these children.
C1 [Vigod, Simone N.; Barker, Lucy C.; Dennis, Cindy-Lee; Brown, Hilary K.] Womens Coll Hosp, Toronto, ON, Canada.
   [Vigod, Simone N.; Barker, Lucy C.; Dennis, Cindy-Lee; Brown, Hilary K.] Womens Coll, Res Inst, Toronto, ON, Canada.
   [Vigod, Simone N.; Barker, Lucy C.; Dennis, Cindy-Lee; Brown, Hilary K.] Univ Toronto, Temerty Fac Med, Dept Psychiat, Toronto, ON, Canada.
   [Vigod, Simone N.; Ray, Joel G.; Cohen, Eyal; Saunders, Natasha R.; Barker, Lucy C.; Tu, Karen; Brown, Hilary K.] Inst Hlth Policy Management & Evaluat, Toronto, ON, Canada.
   [Vigod, Simone N.; Ray, Joel G.; Cohen, Eyal; Wilton, Andrew S.; Saunders, Natasha R.; Barker, Lucy C.; Brown, Hilary K.] ICES, Toronto, ON, Canada.
   [Ray, Joel G.] St Michaels Hosp, Toronto, ON, Canada.
   [Ray, Joel G.] Univ Toronto, Temerty Fac Med, Dept Med, Toronto, ON, Canada.
   [Cohen, Eyal; Saunders, Natasha R.] Hosp Sick Children, Edwin SH Leong Ctr Hlth Children, Toronto, ON, Canada.
   [Cohen, Eyal; Saunders, Natasha R.] Univ Toronto, Temerty Fac Med, Dept Pediat, Toronto, ON, Canada.
   [Berard, Anick] Univ Montreal, Fac Pharm, Montreal, PQ, Canada.
   [Berard, Anick] CHU Ste Justine, Montreal, PQ, Canada.
   [Dennis, Cindy-Lee] Univ Toronto, Lawrence S BloombergFac Nursing, Toronto, ON, Canada.
   [Holloway, Alison C.] McMaster Univ, Dept Obstet & Gynecol, Hamilton, ON, Canada.
   [Morrison, Katherine] McMaster Univ, Dept Pediat, Hamilton, ON, Canada.
   [Oberlander, Tim F.] Univ British Columbia, Dept Pediat, Vancouver, BC, Canada.
   [Hanley, Gillian] Univ British Columbia, Dept Obstet & Gynecol, Vancouver, BC, Canada.
   [Tu, Karen] Univ Toronto, Dept Family & Community Med, Temerty Fac Med, North York Gen Hosp,Toronto Western Hosp,Family H, Toronto, ON, Canada.
   [Brown, Hilary K.] Univ Toronto, Dept Hlth & Soc, Toronto, ON, Canada.
C3 University of Toronto; Womens College Hospital; University of Toronto;
   Women's College Research Institute; University of Toronto; University of
   Toronto; University of Toronto; Saint Michaels Hospital Toronto;
   University of Toronto; University of Toronto; Hospital for Sick Children
   (SickKids); University of Toronto; Universite de Montreal; Universite de
   Montreal; University of Toronto; McMaster University; McMaster
   University; University of British Columbia; University of British
   Columbia; University of Toronto; North York General Hospital; University
   Health Network Toronto; University of Toronto
RP Vigod, SN (corresponding author), Womens Coll Hosp, Dept Psychiat, 76 Grenville St, Toronto, ON, Canada.
EM simone.vigod@wchospital.ca
RI Cohen, Eyal/K-2575-2014; Tu, Karen/MDT-1460-2025; Morrison,
   Katherine/AAO-8046-2021; Dennis, Cindy-Lee/ABA-2860-2020
OI Dennis, Cindy-Lee/0000-0002-0135-7242; Vigod,
   Simone/0000-0002-2736-9639; Hanley, Gillian/0000-0001-9594-0545;
   Oberlander, Tim/0000-0003-4781-6579; Holloway,
   Alison/0000-0002-4343-5325
FU Canadian Institutes for Health Research [PJT156021]
FX This study was funded by an operating grant from the Canadian Institutes
   for Health Research (PJT156021). The funder/sponsor did not participate
   in the work.
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NR 43
TC 3
Z9 3
U1 1
U2 11
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0586-7614
EI 1745-1701
J9 SCHIZOPHRENIA BULL
JI Schizophr. Bull.
PD NOV 18
PY 2022
VL 48
IS 6
BP 1252
EP 1262
DI 10.1093/schbul/sbac091
EA JUL 2022
PG 11
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 6J1VL
UT WOS:000834316900001
PM 35900007
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Manso, MA
   Miguel, M
   Even, J
   Hernández, R
   Aleixandre, A
   López-Fandiño, R
AF Manso, Marfa A.
   Miguel, Marta
   Even, Jeanne
   Hernandez, Rosario
   Aleixandre, Amaya
   Lopez-Fandino, Rosina
TI Effect of the long-term intake of an egg white hydrolysate on the
   oxidative status and blood lipid profile of spontaneously hypertensive
   rats
SO FOOD CHEMISTRY
LA English
DT Article
DE antioxidant status; lipid profile; bioactive peptides; egg white;
   spontaneously hypertensive rats
ID RADICAL-SCAVENGING ACTIVITIES; CONVERTING ENZYME-INHIBITORS; ANTIOXIDANT
   ACTIVITY; METABOLIC SYNDROME; NITRIC-OXIDE; SOY PROTEIN; PEPTIDES;
   CAPTOPRIL; PRESSURE; RENIN
AB This paper examines the effects of the long-term consumption of egg white hydrolysed with pepsin (hEW) on the antioxidant status and lipid profile of spontaneously hypertensive rats (SHR). The antioxidant capacity was measured by the oxygen radical absorbance capacity (ORAC) and the oxidative status by the malon-dialdehyde (MDA) assay. The lipid profile was analysed spectrophotometrically. The radical-scavenging capacity of the plasma was increased and the MDA concentration in the aorta was decreased in the SHR treated with 0.5 g/kg/day of hEW. Our findings indicate that hEW played an important role in antioxidative defence of SHR and exerted a beneficial effect on the lipid profile, lowering triglycerides and total cholesterol without changing HDL levels. Therefore, hEW may be useful to prevent or reverse abnormalities associated with the metabolic syndrome and its complications, such as hypertension, oxidative stress and hyperlipidemia. (C) 2007 Elsevier Ltd. All rights reserved.
C1 [Manso, Marfa A.; Miguel, Marta; Even, Jeanne; Lopez-Fandino, Rosina] CSIC, Inst Fermentac Ind, E-28006 Madrid, Spain.
   [Miguel, Marta; Aleixandre, Amaya] Univ Complutense, Inst Farmacol & Toxicol, CSIC, Fac Med, E-28040 Madrid, Spain.
   [Hernandez, Rosario] Hosp Cent Def, CDEAS, Madrid 28007, Spain.
C3 Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Instituto
   de Fermentaciones Industriales (IFI); Complutense University of Madrid;
   Consejo Superior de Investigaciones Cientificas (CSIC)
RP López-Fandiño, R (corresponding author), CSIC, Inst Fermentac Ind, Juan Cierva 3, E-28006 Madrid, Spain.
EM rosina@ifi.csic.es
RI Manso, Maria/HTR-6904-2023; MIGUEL CASTRO, MARTA/F-6112-2011;
   Lopez-Fandino, Rosina/H-4132-2012
OI MIGUEL CASTRO, MARTA/0000-0002-5525-1056; Lopez-Fandino,
   Rosina/0000-0002-6979-9258; Manso Silvan, Maria
   Asuncion/0000-0002-5056-9065
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NR 46
TC 110
Z9 131
U1 1
U2 57
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0308-8146
EI 1873-7072
J9 FOOD CHEM
JI Food Chem.
PD JUL 15
PY 2008
VL 109
IS 2
BP 361
EP 367
DI 10.1016/j.foodchem.2007.12.049
PG 7
WC Chemistry, Applied; Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Food Science & Technology; Nutrition & Dietetics
GA 285PW
UT WOS:000254789700015
PM 26003359
DA 2025-06-11
ER

PT J
AU Karuparthi, PR
   Yerram, P
   Lastra, G
   Hayden, MR
   Sowers, JR
AF Karuparthi, Poorna R.
   Yerram, Preethi
   Lastra, Guido
   Hayden, Melvin R.
   Sowers, James R.
TI Understanding essential hypertension from the perspective of the
   cardiometabolic syndrome
SO JOURNAL OF THE AMERICAN SOCIETY OF HYPERTENSION
LA English
DT Review
DE Metabolic syndrome; microalbuminuria; endothelial dysfunction; insulin
   resistance; hyperinsulinemia
ID TYPE-2 DIABETES-MELLITUS; JOINT-NATIONAL-COMMITTEE;
   CORONARY-HEART-DISEASE; BLOOD-PRESSURE; INSULIN-RESISTANCE; METABOLIC
   SYNDROME; CARDIOVASCULAR MORBIDITY; GUIDELINE UPDATE; RENIN INHIBITOR;
   DIETARY-SODIUM
AB Hypertension (HTN) is an important modifiable risk factor for major health problems such as coronary heart disease, stroke, congestive heart failure, end-stage renal disease, and peripheral vascular disease. Because of the associated morbidity and mortality, and the cost to society, HTN is an important public health challenge. HTN is frequently associated with other cardiovascular disease risk factors constituting the cardiometabolic syndrome, which individually and synergistically influence the pathophysiology of HTN, and the resultant increased redox stress contributes to the remodeling changes in key organs such as the heart and kidney. Remodeling at the subcellular level, and extracellular matrix in the heart and kidney of the hypertensive Ren2 transgenic rat model of tissue angiotensin II overexpression (TG(mREN-2)27), compared with the Sprague Dawley control rat model, has been observed by light and electron microscopy and are discussed. A better understanding of the pathophysiology of HTN may provide clinician and researcher, tools to effectively investigate and manage this complicated disease process. (C) 2007 American Society of Hypertension. All rights reserved.
C1 [Karuparthi, Poorna R.; Yerram, Preethi; Lastra, Guido; Hayden, Melvin R.] Univ Missouri, Dept Internal Med, Columbia, MO 65201 USA.
   [Hayden, Melvin R.] Univ Missouri, Div Endocrinol Diabet & Metab, Columbia, MO USA.
   [Yerram, Preethi; Lastra, Guido] Vet Affairs Med Ctr, Columbia, MO USA.
   [Sowers, James R.] Arizona Hlth Sci, Ctr Diabet, Div Endocrinol Diabet & Metab, Tucson, AZ USA.
C3 University of Missouri System; University of Missouri Columbia;
   University of Missouri System; University of Missouri Columbia; US
   Department of Veterans Affairs; Veterans Health Administration (VHA);
   University of Arizona Health Sciences
RP Karuparthi, PR (corresponding author), Univ Missouri, Dept Internal Med, Columbia, MO 65201 USA.
EM rkaruparthi@yahoo.com
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NR 90
TC 4
Z9 4
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1933-1711
EI 1878-7436
J9 J AM SOC HYPERTENS
JI J. Am. Soc. Hypertens.
PD MAR-APR
PY 2007
VL 1
IS 2
BP 120
EP 134
DI 10.1016/j.jash.2007.01.006
PG 15
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA V18KL
UT WOS:000208003600006
PM 20409842
DA 2025-06-11
ER

PT J
AU Ashraf, NU
   Sheikh, TA
AF Ashraf, N. U.
   Sheikh, T. A.
TI Endoplasmic reticulum stress and Oxidative stress in the pathogenesis of
   Non-alcoholic fatty liver disease
SO FREE RADICAL RESEARCH
LA English
DT Review
DE ER stress; Oxidative stress; cell death; Non-alcoholic Fatty liver
   disease
ID UNFOLDED PROTEIN RESPONSE; RANDOMIZED CONTROLLED-TRIAL;
   PLACEBO-CONTROLLED-TRIAL; BZIP TRANSCRIPTION FACTORS; LIPID DROPLET
   FORMATION; DOUBLE-EDGED-SWORD; ER STRESS; VITAMIN-E; HEPATIC STEATOSIS;
   INSULIN-RESISTANCE
AB Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic syndrome. The underlying causes of the disease progression in NAFLD are unclear. Recent evidences suggest endoplasmic reticulum stress in the development of lipid droplets (steatosis) and subsequent generation of reactive oxygen species (ROS) in the progression to non-alcoholic steatohepatitis (NASH). The signalling pathway activated by disruption of endoplasmic reticulum (ER) homoeostasis, called as unfolded protein response, is linked with membrane biosynthesis, insulin action, inflammation and apoptosis. ROS are important mediators of inflammation. Protein folding in ER is linked to ROS. Therefore understanding the basic mechanisms that lead to ER stress and ROS in NAFLD have become the topics of immense interest. The present review focuses on the role of ER stress and ROS in the pathogenesis of NAFLD. We also highlight the cross talk between ER stress and oxidative stress which suggest and encourage the development of therapeutics for NAFLD. Further we have reviewed various strategies used for the management of NAFLD/NASH and limitations of such strategies. Our review therefore highlights the need for newer strategies with regards to ER stress and oxidative stress.
C1 [Ashraf, N. U.; Sheikh, T. A.] Acad Sci & Innovat Res AcSIR, New Delhi, India.
   [Ashraf, N. U.; Sheikh, T. A.] CSIR, Indian Inst Integrat Med, PK PD & Toxicol Div, Jammu, Jammu & Kashmir, India.
   [Sheikh, T. A.] PK PD & Toxicol Div, Jammu, India.
C3 Academy of Scientific & Innovative Research (AcSIR); Council of
   Scientific & Industrial Research (CSIR) - India; CSIR - Indian Institute
   of Integrative Medicine (IIIM)
RP Sheikh, TA (corresponding author), CSIR, Indian Inst Integrat Med, Canal Rd, Jammu, Jammu & Kashmir, India.
EM stabdullah@iiim.ac.in
FU Council of Scientific and Industrial research (CSIR), New Delhi;
   University Grants Commission (UGC), New Delhi
FX Council of Scientific and Industrial research (CSIR), New Delhi and
   University Grants Commission (UGC), New Delhi are acknowledged for
   financial assistance.
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NR 172
TC 244
Z9 279
U1 6
U2 111
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1071-5762
EI 1029-2470
J9 FREE RADICAL RES
JI Free Radic. Res.
PY 2015
VL 49
IS 12
BP 1405
EP 1418
DI 10.3109/10715762.2015.1078461
PG 14
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA DD4KW
UT WOS:000369892800001
PM 26223319
DA 2025-06-11
ER

PT J
AU Wang, J
   Sereika, SM
   Styn, MA
   Burke, LE
AF Wang, Jing
   Sereika, Susan M.
   Styn, Mindi A.
   Burke, Lora E.
TI Factors associated with health-related quality of life among overweight
   or obese adults
SO JOURNAL OF CLINICAL NURSING
LA English
DT Article
DE barriers; health-related quality of life; obesity; self-efficacy; Short
   Form-36 Health Survey; stress
ID BODY-MASS INDEX; LOW-ENERGY DIET; WEIGHT-LOSS; BEHAVIOR-MODIFICATION;
   METABOLIC SYNDROME; LOSING WEIGHT; US ADULTS; MAINTENANCE; TRIAL; COST
AB Aims and objectives To identify factors associated with health-related quality of life among overweight or obese adults.
   Background The obesity epidemic presents a global challenge. Obesity is associated with lower health-related quality of life; however, no study has comprehensively examined correlates of health-related quality of life in this population.
   Design A cross-sectional design.
   Methods The physical component score, mental component score and eight domain scores of the Short Form-36 v2 were used to assess health-related quality of life. We identified 23 possible correlates of health-related quality of life, including age, body mass index, health and weight histories, perceived stress, cholesterol-lowering diet self-efficacy, problem-solving, binge eating, dietary intake and physical activity. Correlational analyses were used to examine the bivariate associations between correlates and health-related quality of life variables. All possible subsets regression was used to develop predictive models of health-related quality of life.
   Results The sample (n=210) was predominantly White (848%), female (781%) and middle-aged (average age=4680years). Age, body mass index, education, having children at home, and being hypertensive were identified as the best predictors of physical component score, explaining about 9% of the variance. Age, marital status, having hyperlipidaemia, perceived stress, problem-solving, self-efficacy, binge eating and barriers to healthy eating predicted mental component score, explaining approximately 48% of the variance. Physical functioning and role physical domains of health-related quality of life had similar sets of predictors, with 15% and 13% of the variance explained, respectively, while similar predictors were identified for bodily pain (6%), general health (26%), vitality (40%), social functioning (32%), role emotional (42%) and mental health (46%) domains.
   Conclusions Psychosocial factors were associated with the mental-related quality of life. Further exploration of factors related to physical-related quality of life is warranted in this population.
   Relevance to clinical practiceWhen working with overweight/obese adults who are trying to lose weight, nurses need to consider socio-demographic and psychosocial factors in the development of a treatment plan that will improve health-related quality of life in this population.
C1 [Wang, Jing] Univ Texas Hlth Sci Ctr Houston, Sch Nursing, Dept Nursing Syst, Houston, TX 77030 USA.
   [Sereika, Susan M.; Styn, Mindi A.; Burke, Lora E.] Univ Pittsburgh, Sch Nursing, Dept Hlth & Community Syst, Pittsburgh, PA 15261 USA.
C3 University of Texas System; University of Texas Health Science Center
   Houston; Pennsylvania Commonwealth System of Higher Education (PCSHE);
   University of Pittsburgh
RP Wang, J (corresponding author), Univ Texas Hlth Sci Ctr Houston, Sch Nursing, Dept Nursing Syst, 6901 Bertner Ave,SON Room 614, Houston, TX 77030 USA.
EM Jing.Wang@uth.tmc.edu
FU NIH/NIDDK [R01 DK071817]; Data Management Core of the Center for
   Research in Chronic Disorders NIH-NINR [P30-NR03924]; General Clinical
   Research Center, NIH-NCRR-GCRC [5M01-RR000056]; Clinical Translational
   Research Center, NIH/NCRR/CTSA at the University of Pittsburgh [UL1
   RR024153]; NIH/NINR [K24-NR010742]
FX The parent study was supported by NIH/NIDDK # R01 DK071817. The conduct
   of the parent study was also supported by the Data Management Core of
   the Center for Research in Chronic Disorders NIH-NINR #P30-NR03924, the
   General Clinical Research Center, NIH-NCRR-GCRC #5M01-RR000056 and the
   Clinical Translational Research Center, NIH/NCRR/CTSA Grant UL1 RR024153
   at the University of Pittsburgh. This work was supported by NIH/NINR
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NR 50
TC 37
Z9 54
U1 0
U2 49
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0962-1067
EI 1365-2702
J9 J CLIN NURS
JI J. Clin. Nurs.
PD AUG
PY 2013
VL 22
IS 15-16
BP 2172
EP 2182
DI 10.1111/jocn.12280
PG 11
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA 176UU
UT WOS:000321332100010
PM 23829404
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Arruda, HS
   Neri-Numa, IA
   Kido, LA
   Maróstica, MR Jr
   Pastore, GM
AF Arruda, Henrique Silvano
   Neri-Numa, Iramaia Angelica
   Kido, Larissa Akemi
   Marostica Junior, Mario Roberto
   Pastore, Glaucia Maria
TI Recent advances and possibilities for the use of plant phenolic
   compounds to manage ageing-related diseases
SO JOURNAL OF FUNCTIONAL FOODS
LA English
DT Article
DE Polyphenols; Neurodegenerative diseases; Metabolic syndrome; Cancer;
   Inflammation; Oxidative stress
ID BREAST-CANCER CELLS; DIETARY POLYPHENOL INTAKE; MAJOR FOOD SOURCES;
   GREEN TEA EXTRACT; Y GASTRIC BYPASS; METABOLIC SYNDROME;
   PROSTATE-CANCER; COGNITIVE FUNCTION; HUNTINGTONS-DISEASE;
   PARKINSONS-DISEASE
AB Ageing is an emerging global public health concern due to the increasing number of elderly people and ageing related degenerative disorders. Given the absence of effective treatments to manage ageing-related diseases, increasing efforts have been directed to find ways to reduce the risk of developing these disorders. Among them, plant phytochemicals, such as phenolic compounds, are considered potential anti-ageing agents due to their multifaceted biochemical actions. In this review, we focus on presenting the results of the last few years and pioneer researches mainly with animal models and human trials showing the key role of phenolic compounds as potential anti-ageing agents. Recent advances demonstrated that several phenolic compounds can reduce the risk and/or delay ageing-related disorders, including neurodegenerative diseases, metabolic syndromes, and cancers particularly by modulating signalling pathways involved in inflammation, oxidative damage, autophagy, and apoptosis. Therefore, plant phenolic compounds can be a complementary and alternative tool for managing ageing-related diseases.
C1 [Arruda, Henrique Silvano; Neri-Numa, Iramaia Angelica; Pastore, Glaucia Maria] Univ Estadual Campinas, Sch Food Engn, Dept Food Sci, Bioflavors & Bioact Cpds Lab, Monteiro Lobato St 80, BR-13083862 Campinas, SP, Brazil.
   [Arruda, Henrique Silvano; Kido, Larissa Akemi; Marostica Junior, Mario Roberto] Univ Estadual Campinas, Sch Food Engn, Dept Food & Nutr, Nutr & Metab Lab, Monteiro Lobato St 80, BR-13083862 Campinas, SP, Brazil.
   [Kido, Larissa Akemi] Univ Estadual Campinas, Inst Biol, Dept Struct & Funct Biol, Reprod Biol Lab, Bertrand Russel Ave S-N, BR-13083865 Campinas, SP, Brazil.
C3 Universidade Estadual de Campinas; Universidade Estadual de Campinas;
   Universidade Estadual de Campinas
RP Arruda, HS; Pastore, GM (corresponding author), Univ Estadual Campinas, Sch Food Engn, Monteiro Lobato St 80, BR-13083862 Campinas, SP, Brazil.
EM hsilvanoarruda@gmail.com; glaupast@unicamp.br
RI Numa, Iramaia/T-7472-2019; Kido, Larissa/J-4884-2017; Marostica,
   Mario/P-5936-2018; Arruda, Henrique/O-1846-2018
OI Arruda, Henrique/0000-0003-4963-5042
FU Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior - Brazil
   (CAPES) [001]; Conselho Nacional de Desenvolvimento Cientifico e
   Tecnologico (CNPq) [403328/2016-0, 301496/2019-6, 406820/2018-0];
   Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
   [2015/50333-1, 2018/11069-5, 2015/13320-9]; CAPES
   [88887.469390/2019-00]; FAPESP [2017/01573-5]; Red Iberomericana de
   Aprovechamiento Integral de Alimentos Autoctonos Subutilizados
   (ALSUB-CYTED) [118RT0543]
FX This study was financed in part by the Coordenacao de Aperfeicoamento de
   Pessoal de Nivel Superior - Brazil (CAPES, Finance Code 001), Conselho
   Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq, grant
   numbers 403328/2016-0, 301496/2019-6 and 406820/2018-0) and Fundacao de
   Amparo a Pesquisa do Estado de Sao Paulo (FAPESP, grant numbers
   2015/50333-1, 2018/11069-5 and 2015/13320-9). Henrique Silvano Arruda
   thanks the CAPES (grant number 88887.469390/2019-00) for his
   postdoctoral assistantship. Larrisa Akemi Kido thanks the FAPESP (grant
   number 2017/01573-5) for her postdoctoral assistantship. Mario Roberto
   Marostica Junior acknowledges Red Iberomericana de Aprovechamiento
   Integral de Alimentos Autoctonos Subutilizados (ALSUB-CYTED, 118RT0543).
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NR 287
TC 44
Z9 48
U1 2
U2 50
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1756-4646
EI 2214-9414
J9 J FUNCT FOODS
JI J. Funct. Food.
PD DEC
PY 2020
VL 75
AR 104203
DI 10.1016/j.jff.2020.104203
PG 35
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA PH4DG
UT WOS:000600364900004
OA gold
DA 2025-06-11
ER

PT J
AU Stone, WL
   Schetzina, K
   Stuart, C
AF Stone, William L.
   Schetzina, Karen
   Stuart, Charles
TI Childhood obesity: a systems medicine approach
SO FRONTIERS IN BIOSCIENCE-LANDMARK
LA English
DT Article
DE Pediatrics; Systems Biology; Medicine; Obesity; Genomics; Genome Wide
   Association Studies; Diabetes; Metabolic Syndrome; Proteomics;
   Metabolomics; Metagenomics; Review
ID ISLET AMYLOID POLYPEPTIDE; OXIDATIVE STRESS; INSULIN-RESISTANCE;
   METABOLIC SYNDROME; SKELETAL-MUSCLE; CARDIOVASCULAR RISK; GLUT4
   EXPRESSION; VITAMIN-E; CHILDREN; ADIPOSE
AB Childhood obesity and its sequelae are a major public health problem in both the USA and globally. This review will focus on a systems medicine approach to obesity. Systems medicine is an integrative approach utilizing the vast amount of data garnered from "omics" technology and integrating these data with conventional pathophysiology as well as diverse environmental factors such as diet, exercise, community dynamics and the intestinal microbiome. Omics technology includes genomics, epigenomics, metagenomics, metabolomics and proteomics. In addition to unraveling etiology, the goals of a systems medicine approach are to provide actionable and evidenced-based clinical approaches. In the case of childhood obesity, an additional goal is characterizing measureable risk factors/biomarkers for obesity at the earliest possible age and devising age-appropriate optimal intervention strategies. It is also important to establish the age at which interventions could be critical. As discussed below, it is possible that some of the pathophysiological and epigenetic changes resulting from childhood obesity could become more irreversible the longer the obesity remains untreated.
C1 [Stone, William L.; Schetzina, Karen] E Tennessee State Univ, James H Quillen Coll Med, Dept Pediat, Johnson City, TN 37614 USA.
   [Stuart, Charles] E Tennessee State Univ, James H Quillen Coll Med, Dept Internal Med, Johnson City, TN 37614 USA.
C3 East Tennessee State University; East Tennessee State University
RP Stone, WL (corresponding author), E Tennessee State Univ, James H Quillen Coll Med, Dept Pediat, Johnson City, TN 37614 USA.
EM stone@etsu.edu
RI Stone, William/B-6499-2008
OI Stone, William/0000-0002-6829-0417
FU National Institutes of Health [C06RR0306551]; East Tennessee State
   University Robert W. Summers Pediatric Research Endowment
FX This research was supported in part by the National Institutes of Health
   grant C06RR0306551 and the East Tennessee State University Robert W.
   Summers Pediatric Research Endowment. WLS wrote the first draft of this
   paper and both KS and CS contributed new sections and helped with the
   overall preparation of the final manuscript.
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NR 78
TC 3
Z9 3
U1 0
U2 30
PU FRONTIERS IN BIOSCIENCE INC
PI IRVINE
PA 16471 SCIENTIFIC WAY, IRVINE, CA 92618 USA
SN 1093-9946
EI 1093-4715
J9 FRONT BIOSCI-LANDMRK
JI Front. Biosci.
PD JUN 1
PY 2016
VL 21
BP 1061
EP 1075
DI 10.2741/4441
PG 15
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA DK0EB
UT WOS:000374584300016
PM 27100491
DA 2025-06-11
ER

PT J
AU Balsevich, G
   Uribe, A
   Wagner, KV
   Hartmann, J
   Santarelli, S
   Labermaier, C
   Schmidt, MV
AF Balsevich, Georgia
   Uribe, Andres
   Wagner, Klaus V.
   Hartmann, Jakob
   Santarelli, Sara
   Labermaier, Christiana
   Schmidt, Mathias V.
TI Interplay between diet-induced obesity and chronic stress in mice:
   potential role of FKBP51
SO JOURNAL OF ENDOCRINOLOGY
LA English
DT Article
DE glucocorticoid receptor; obesity; HPA axis; gene expression
ID CHRONIC SOCIAL STRESS; PITUITARY-ADRENAL AXIS; METABOLIC SYNDROME;
   ENERGY-BALANCE; GLUCOCORTICOID-RECEPTOR; PSYCHOSOCIAL STRESS; CHILDHOOD
   TRAUMA; NEUROPEPTIDE-Y; DEFEAT STRESS; GENE
AB While it is known that stress promotes obesity, the effects of stress within an obesogenic context are not so clear and molecular targets at the interface remain elusive. The FK506-binding protein 51 (FKBP51, gene: Fkbp5) has been identified as a target gene implicated in the development of stress-related psychiatric disorders and is a possible candidate for involvement in stress and metabolic regulation. The aims of the current study are to investigate the interaction between chronic stress and an obesogenic context and to additionally examine whether FKBP51 is involved in this interaction. For this purpose, male C57BL/6 mice were exposed to a high-fat diet for 8 weeks before being challenged with chronic social defeat stress. Herein, we demonstrate that chronic stress induces hypophagia and weight loss, ultimately improving features arising from an obesogenic context, including glucose tolerance and levels of insulin and leptin. We show that Fkbp5 expression is responsive to diet and stress in the hypothalamus and hippocampus respectively. Furthermore, under basal conditions, higher levels of hypothalamic Fkbp5 expression were related to increased body weight gain. Our data indicate that Fkbp5 may represent a novel target in metabolic regulation.
C1 [Balsevich, Georgia; Uribe, Andres; Wagner, Klaus V.; Hartmann, Jakob; Santarelli, Sara; Labermaier, Christiana; Schmidt, Mathias V.] Max Planck Inst Psychiat, D-80804 Munich, Germany.
C3 Max Planck Society
RP Balsevich, G (corresponding author), Max Planck Inst Psychiat, Kraepelinstr 2-10, D-80804 Munich, Germany.
EM georgia_balsevich@mpipsykl.mpg.de
RI Santarelli, Sara/JMQ-8361-2023; Hartmann, Jakob/GPF-5919-2022
OI Balsevich, Georgia/0000-0002-7839-018X; Hartmann,
   Jakob/0000-0002-1960-8177; Schmidt, Mathias/0000-0002-3788-2268
FU European Commission Seventh Framework Program [278603]
FX This work was supported by the European Commission Seventh Framework
   Program (FP7, project number 278603).
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NR 60
TC 61
Z9 63
U1 0
U2 9
PU BIOSCIENTIFICA LTD
PI BRISTOL
PA EURO HOUSE, 22 APEX COURT WOODLANDS, BRADLEY STOKE, BRISTOL BS32 4JT,
   ENGLAND
SN 0022-0795
EI 1479-6805
J9 J ENDOCRINOL
JI J. Endocrinol.
PD JUL
PY 2014
VL 222
IS 1
BP 15
EP 26
DI 10.1530/JOE-14-0129
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA AL6QE
UT WOS:000339256800005
PM 24781256
DA 2025-06-11
ER

PT J
AU Doulberis, M
   Kotronis, G
   Gialamprinou, D
   Kountouras, J
   Katsinelos, P
AF Doulberis, Michael
   Kotronis, Georgios
   Gialamprinou, Dimitra
   Kountouras, Jannis
   Katsinelos, Panagiotis
TI Non-alcoholic fatty liver disease: An update with special focus on the
   role of gut microbiota
SO METABOLISM-CLINICAL AND EXPERIMENTAL
LA English
DT Review
DE NAFLD; Gut microbiota; Probiotics; Gastrointestinal bacteria; Metabolic
   syndrome; Obesity
ID HELICOBACTER-PYLORI INFECTION; ENDOPLASMIC-RETICULUM STRESS; IMPROVES
   INSULIN-RESISTANCE; HEPATIC STEATOSIS; WIDE ASSOCIATION;
   NATURAL-HISTORY; VITAMIN-E; INTESTINAL MICROBIOTA; URSODEOXYCHOLIC ACID;
   MOLECULAR-MECHANISMS
AB Non-alcoholic fatty liver disease (NAFLD) is a significant global health burden in children, adolescents and adults with substantial rise in prevalence over the last decades. Accumulating data from manifold studies support the idea of NAFLD as a hepatic manifestation of metabolic syndrome, being rather a systemic metabolic disease than a liver confined pathology. Emerging data support that the gut microbiome represents a significant environmental factor contributing to NAFLD development and progression. Apart from other regimens, probiotics may have a positive role in the management of NAFLD through a plethora of possible mechanisms. The current review focuses on the NAFLD multifactorial pathogenesis, including mainly the role of intestinal microbiome and all relevant issues are raised. Furthermore, the clinical manifestations and appropriate diagnostic approach of the disease are discussed, with all possible therapeutic measures that can be taken, also including the potential beneficial effect of probiotics. (C) 2017 Elsevier Inc. All rights reserved.
C1 [Doulberis, Michael] Burgerspital Hosp, Dept Internal Med, Schongrunstr 38, CH-4500 Solothurn, Switzerland.
   [Kotronis, Georgios] Agios Paulos Hosp, Dept Internal Med, Thessaloniki 55134, Macedonia, Greece.
   [Gialamprinou, Dimitra] Aristotle Univ Thessaloniki, Papageorgiou Gen Hosp, Dept Pediat, Thessaloniki 56403, Macedonia, Greece.
   [Kountouras, Jannis; Katsinelos, Panagiotis] Aristotle Univ Thessaloniki, Med Clin 2, Dept Internal Med, Ippokrat Hosp, Thessaloniki 54642, Macedonia, Greece.
C3 Papageorgiou Hospital; Aristotle University of Thessaloniki; Aristotle
   University of Thessaloniki
RP Doulberis, M (corresponding author), Burgerspital Hosp, Dept Internal Med, Schongrunstr 38, CH-4500 Solothurn, Switzerland.
EM doulberis@gmail.com
RI Doulberis, Michael/Y-5118-2018
OI Doulberis, Michael/0000-0002-0396-5081; Kotronis,
   Georgios/0000-0003-3767-6365
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NR 150
TC 82
Z9 89
U1 2
U2 73
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0026-0495
EI 1532-8600
J9 METABOLISM
JI Metab.-Clin. Exp.
PD JUN
PY 2017
VL 71
BP 182
EP 197
DI 10.1016/j.metabol.2017.03.013
PG 16
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA EW5YW
UT WOS:000402583400019
PM 28521872
DA 2025-06-11
ER

PT J
AU Gundala, NKV
   Naidu, VGM
   Das, UN
AF Gundala, Naveen K. V.
   Naidu, Vegi G. M.
   Das, Undurti N.
TI Amelioration of streptozotocin-induced type 2 diabetes mellitus in
   Wistar rats by arachidonic acid
SO BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
LA English
DT Article
DE Type 2 diabetes mellitus; Streptozotocin; Arachidonic acid; Lipoxin A4;
   Insulin; Wistar rats; Anti-oxidants; Lipocaln2; Cytokines; Glucose
ID POLYUNSATURATED FATTY-ACIDS; ALLOXAN-INDUCED CYTOTOXICITY; FACTOR-ALPHA
   BLOCKADE; METABOLIC SYNDROME-X; CELLS IN-VITRO; INSULIN-RESISTANCE;
   INFLAMMATORY CONDITION; OXIDATIVE STRESS; ASPIRIN; GLUCOSE
AB Traditionally arachidonic acid (AA, 20:4 n-6) is considered as a pro-inflammatory molecule since it forms precursor to prostaglandins (PGs), leukotrienes (LTs) and thromboxanes (TXs) that have pro inflammatory actions. Type 2 diabetes mellitus (type 2 DM) is considered as a low-grade systemic inflammatory condition in which circulating PGs and LTs are increased. Streptozotocin (STZ)-induced type 2 DM is used as a model of human type 2 DM in which peripheral insulin resistance, increased plasma interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) and hyperglycemia occurs. In the present study, we observed that oral supplementation of AA prevented STZ-induced type 2 DM in Wistar rats by restoring hyperglycemia, plasma levels of TNF-alpha and IL-6; adipose tissue NF-kappa B and lipocalin 2 (LPCLN2) and pancreatic tissue NF-kappa B and 5- and 12- lipoxygenase enzymes to normal. AA treatment enhanced insulin sensitivity and plasma lipoxin A4 (LXA4) levels, a potent anti-inflammatory molecule derived from AA. These results are supported by our previous studies wherein it was noted that plasma phospholipid content of AA and circulating LXA4 levels are low in those with type 2 DM. In a preliminary study, we also noted that high-fat-diet (HFD)-induced type 2 DM in Wistar rats can be prevented by oral supplementation of AA. These results suggest AA has anti-inflammatory and anti-diabetic actions by enhancing the production of its anti-inflammatory metabolite LXA4. (C) 2018 Elsevier Inc. All rights reserved.
C1 [Gundala, Naveen K. V.; Das, Undurti N.] Gayatri Vidya Parishad Hosp, BioSci Res Ctr, Dept Med, GVP Coll Engn Campus, Visakhapatnam 530048, Andhra Pradesh, India.
   [Naidu, Vegi G. M.] Natl Inst Pharmaceut Educ & Res, Gauhati, India.
   [Das, Undurti N.] UND Life Sci, 2221 NW 5th St, Battle Ground, WA 98604 USA.
C3 Gayatri Vidya Parishad College of Engineering; National Institute of
   Pharmaceutical Education & Research, S.A.S. Nagar (Mohali)
RP Das, UN (corresponding author), Gayatri Vidya Parishad Hosp, BioSci Res Ctr, Dept Med, GVP Coll Engn Campus, Visakhapatnam 530048, Andhra Pradesh, India.
EM undurti@lipidworld.com
RI Das, Undurti/A-7918-2009; Gundala, Venkata Naveen/L-8395-2019
OI Naidu, VGM/0000-0003-1520-2177; Das, Undurti/0000-0002-0191-9508
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NR 46
TC 55
Z9 60
U1 0
U2 15
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0006-291X
EI 1090-2104
J9 BIOCHEM BIOPH RES CO
JI Biochem. Biophys. Res. Commun.
PD JAN 29
PY 2018
VL 496
IS 1
BP 105
EP 113
DI 10.1016/j.bbrc.2018.01.007
PG 9
WC Biochemistry & Molecular Biology; Biophysics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics
GA FU7YF
UT WOS:000424068000018
PM 29309791
DA 2025-06-11
ER

PT J
AU Hendrie, HC
   Tu, WZ
   Tabbey, R
   Purnell, CE
   Ambuehl, RJ
   Callahan, CM
AF Hendrie, Hugh C.
   Tu, Wanzhu
   Tabbey, Rebeka
   Purnell, Christianna E.
   Ambuehl, Roberta J.
   Callahan, Christopher M.
TI Health Outcomes and Cost of Care Among Older Adults with Schizophrenia:
   A 10-Year Study Using Medical Records Across the Continuum of Care
SO AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
LA English
DT Article
DE Comorbidity; mortality; dementia; cancer; nursing home; hospital care
ID NURSING-HOME ADMISSION; MENTAL-ILLNESS; METABOLIC SYNDROME;
   CANCER-MORTALITY; RELATIVE RISK; DEMENTIA; ASSOCIATION; COMORBIDITY;
   PERFORMANCE; PREVALENCE
AB Objectives: The population of older patients with schizophrenia is increasing. This study describes health outcomes, utilization, and costs over 10 years in a sample of older patients with schizophrenia compared with older patients without schizophrenia. Methods: An observational cohort study of 31,588 older adults (mean age: 70.44 years) receiving care from an urban public health system, including a community mental health center, during 1999-2008. Of these, 1,635 (5.2%) were diagnosed with schizophrenia and 757 (2.4%) had this diagnosis confirmed in the community mental health center. Patients' electronic medical records were merged with Medicare claims, Medicaid claims, the Minimum Dataset, and the Outcome and Assessment Information Set. Information on medication use was not available. Measurements: Rates of comorbid conditions, healthcare utilization, costs, and mortality. Results: Patients with schizophrenia had significantly higher rates of congestive heart failure (45.05% versus 38.84%), chronic obstructive pulmonary disease (52.71% versus 41.41%), and hypothyroidism (36.72% versus 26.73%) than the patients without schizophrenia (p < 0.001). They had significantly lower rates of cancer (30.78% versus 43.18%) and significantly higher rates of dementia (64.46% versus 32.13%). The patients with schizophrenia had significantly higher mortality risk (hazard ratio: 1.25, 95% confidence interval: 1.07-1.47) than the patients without schizophrenia. They also had significantly higher rates of healthcare utilization. The mean costs for Medicare and Medicaid were significantly higher for the patients with schizophrenia than for the patients without schizophrenia. Conclusions: The management of older adult patients with schizophrenia is creating a serious burden for our healthcare system, requiring the development of integrated models of healthcare.
C1 [Hendrie, Hugh C.; Callahan, Christopher M.] Indiana Univ Sch Med, Indianapolis, IN 46202 USA.
   [Hendrie, Hugh C.; Purnell, Christianna E.; Callahan, Christopher M.] Indiana Univ, Ctr Aging Res, Indianapolis, IN 46202 USA.
   [Hendrie, Hugh C.; Ambuehl, Roberta J.; Callahan, Christopher M.] Regenstrief Inst Inc, Indianapolis, IN USA.
   [Hendrie, Hugh C.] Indiana Univ Sch Med, Dept Psychiat, Indianapolis, IN 46202 USA.
   [Tu, Wanzhu; Tabbey, Rebeka] Indiana Univ Sch Med, Dept Biostat, Indianapolis, IN 46202 USA.
C3 Indiana University System; Indiana University Bloomington; Indiana
   University System; Indiana University Indianapolis; Regenstrief
   Institute Inc; Indiana University System; Indiana University
   Bloomington; Indiana University System; Indiana University Bloomington
RP Hendrie, HC (corresponding author), Indiana Univ, Ctr Aging Res, 410 West 10th St,Ste 2000, Indianapolis, IN 46202 USA.
EM hhendri@iupui.edu
FU National Institutes of Health [R24 MH080827, R01 AG031222]
FX This work was supported by the National Institutes of Health (R24
   MH080827 and R01 AG031222). All authors were supported by an institution
   which received funding from these two grants.
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NR 41
TC 45
Z9 51
U1 0
U2 15
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1064-7481
EI 1545-7214
J9 AM J GERIAT PSYCHIAT
JI Am. J. Geriatr. Psychiatr.
PD MAY
PY 2014
VL 22
IS 5
BP 427
EP 436
DI 10.1016/j.jagp.2012.10.025
PG 10
WC Geriatrics & Gerontology; Gerontology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Psychiatry
GA AH4HE
UT WOS:000336087200002
PM 23933423
OA Green Accepted, Green Published
DA 2025-06-11
ER

PT J
AU Tietel, Z
   Ananth, DA
   Sivasudha, T
   Klipcan, L
AF Tietel, Zipora
   Ananth, Devanesan Arul
   Sivasudha, Thilagar
   Klipcan, Liron
TI Cassia auriculata L.-A mini review of phytochemical
   compounds and their antidiabetic mechanisms
SO AIMS AGRICULTURE AND FOOD
LA English
DT Review
DE C. auriculata; avaram; medicinal properties; specialized metabolites;
   metabolic syndrome; hypoglycemic; hypolipidemic
ID TYPE-2 DIABETES-MELLITUS; MALE WISTAR RATS; HIGH-FAT-DIET; OXIDATIVE
   STRESS; D-PINITOL; D-SORBOSE; CHEMICAL-STRUCTURES; INSULIN-RESISTANCE;
   PYROGLUTAMIC ACID; FLOWER EXTRACT
AB Cassia auriculata is an important medicinal herb traditionally used for the treatment and management of diabetes. Scientific research has reported some bioactivities related to traditional roles that include antihyperglycemic and antihyperlipidemic, which could inhibit onset of diabetes. Our aim was twofold: To review the presence of phytochemical compounds in plant extracts and to perform an in-papyro evaluation of their antidiabetic potential. A detailed literature survey was carried out for evaluating metabolic syndrome -related medicinal bioactivities and antidiabetic activity from specific compounds of C. auriculata. We uncovered a wide range of medicinal uses of C. auriculata in Ayurveda and Sri Lankan medicinal traditions and cultures. Many of the compounds in C. auriculata extracts have already been reported for their specific antidiabetic, hypoglycemic, and hypolipidemic activities, which exhibited positive effects on neuro, renal, and liver support. In conclusion, our findings suggested that the phytocomposition of C. auriculata could be attributed to the presence of antidiabetic activity through various mechanisms.
C1 [Tietel, Zipora; Ananth, Devanesan Arul; Klipcan, Liron] Agr Res Org, Food Sci, Gilat Res Ctr, Volcani Inst, IL-8531100 Negev, Israel.
   [Ananth, Devanesan Arul] Amer Coll Madurai, Dept Biotechnol, Satellite Campus, Madurai, Tamil Nadu, India.
   [Sivasudha, Thilagar] Bharathidasan Univ, Dept Environm Biotechnol, Tiruchirappalli 620024, Tamil Nadu, India.
C3 VOLCANI INSTITUTE OF AGRICULTURAL RESEARCH; Bharathidasan University
RP Tietel, Z (corresponding author), Agr Res Org, Food Sci, Gilat Res Ctr, Volcani Inst, IL-8531100 Negev, Israel.
EM tietel@agri.gov.il
RI Thilagar, Sivasudha/AAZ-7386-2020; Devanesan, Arul Ananth/AAA-6237-2022
OI Thilagar, Sivasudha/0000-0001-6460-1612
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NR 132
TC 0
Z9 1
U1 2
U2 4
PU AMER INST MATHEMATICAL SCIENCES-AIMS
PI SPRINGFIELD
PA PO BOX 2604, SPRINGFIELD, MO 65801-2604, UNITED STATES
SN 2471-2086
J9 AIMS AGRIC FOOD
JI AIMS AGRIC. FOOD
PY 2024
VL 9
IS 1
BP 374
EP 392
DI 10.3934/agrfood.2024022
PG 19
WC Agriculture, Multidisciplinary; Agronomy; Food Science & Technology
WE Emerging Sources Citation Index (ESCI)
SC Agriculture; Food Science & Technology
GA MX2H4
UT WOS:001196864600001
OA gold
DA 2025-06-11
ER

PT J
AU Rizvi, AA
AF Rizvi, Ali A.
TI Hypertension, Obesity, and Inflammation: The Complex Designs of a Deadly
   Trio
SO METABOLIC SYNDROME AND RELATED DISORDERS
LA English
DT Review
ID C-REACTIVE PROTEIN; ANGIOTENSIN-CONVERTING-ENZYME; VASCULAR
   SMOOTH-MUSCLE; FACTOR-KAPPA-B; ENDOTHELIAL GROWTH-FACTOR; TYPE-1
   RECEPTOR BLOCKADE; II INDUCES INTERLEUKIN-6; CORONARY-HEART-DISEASE;
   CHRONIC KIDNEY-DISEASE; NECROSIS-FACTOR-ALPHA
AB Hypertension is a powerful risk factor for cardiovascular disease and frequently occurs in conjunction with obesity and the metabolic syndrome. Recent research into the underlying pathophysiologic processes common to these entities has uncovered the role of a heightened inflammatory state signified by a host of circulating biocytokines. Systemic and local hormonal effectors, such as angiotensin II and aldosterone, interact with inflammatory and oxidative stress to augment endothelial damage in a complex manner. The kidneys play a prominent role in the renin-angiotensin cascade and the abnormal pressor response that ensues. Insulin resistance underlies the pathogenesis of obesity and the metabolic syndrome. The interplay of hypertension, insulin resistance, and obesity vastly enhances the noxious influence of inflammation on the vasculature, promoting deleterious immune adaptations and ultimately increasing atherosclerotic risk. Although certain classes of available pharmacologic agents already address the altered endovascular and humoral dynamics in hypertension, a better understanding of the proinflammatory picture holds promise of targeted treatment modalities in future.
C1 [Rizvi, Ali A.] Univ S Carolina, Sch Med, Dept Med, Univ Diabet & Endocrinol Ctr, Columbia, SC 29208 USA.
C3 University of South Carolina System; University of South Carolina
   Columbia
RP Rizvi, AA (corresponding author), 2 Med Pk,Suite 502, Columbia, SC 29203 USA.
EM ali.rizvi@uscmed.sc.edu
RI Rizvi, Ali/AFV-2240-2022
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NR 103
TC 29
Z9 31
U1 0
U2 1
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-4196
EI 1557-8518
J9 METAB SYNDR RELAT D
JI Metab. Syndr. Relat. Disord.
PD AUG
PY 2010
VL 8
IS 4
BP 287
EP 294
DI 10.1089/met.2009.0116
PG 8
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 637GA
UT WOS:000280803500001
PM 20367224
DA 2025-06-11
ER

PT J
AU Jahng, JWS
   Alsaadi, RM
   Palanivel, R
   Song, EF
   Hipolito, VEB
   Sung, HK
   Botelho, RJ
   Russell, RC
   Sweeney, G
AF Jahng, James Won Suk
   Alsaadi, Reham Musaibeh
   Palanivel, Rengasamy
   Song, Erfei
   Hipolito, Victoria Emily Barbosa
   Sung, Hye Kyoung
   Botelho, Roberto Jorge
   Russell, Ryan Charles
   Sweeney, Gary
TI Iron overload inhibits late stage autophagic flux leading to insulin
   resistance
SO EMBO REPORTS
LA English
DT Article
DE ALR; autophagy; insulin resistance; iron overload; mTORC1
ID OXIDATIVE STRESS; MAMMALIAN TARGET; CARDIOMYOCYTE APOPTOSIS; SECRETORY
   CAPACITY; REGULATE AUTOPHAGY; RAPAMYCIN MTOR; CELLS; ADIPONECTIN;
   SENSITIVITY; HOMEOSTASIS
AB Iron overload, a common clinical occurrence, is implicated in the metabolic syndrome although the contributing pathophysiological mechanisms are not fully defined. We show that prolonged iron overload results in an autophagy defect associated with accumulation of dysfunctional autolysosomes and loss of free lysosomes in skeletal muscle. These autophagy defects contribute to impaired insulin-stimulated glucose uptake and insulin signaling. Mechanistically, we show that iron overload leads to a decrease in Akt-mediated repression of tuberous sclerosis complex (TSC2) and Rheb-mediated mTORC1 activation on autolysosomes, thereby inhibiting autophagic-lysosome regeneration. Constitutive activation of mTORC1 or iron withdrawal replenishes lysosomal pools via increased mTORC1-UVRAG signaling, which restores insulin sensitivity. Induction of iron overload via intravenous iron-dextran delivery in mice also results in insulin resistance accompanied by abnormal autophagosome accumulation, lysosomal loss, and decreased mTORC1-UVRAG signaling in muscle. Collectively, our results show that chronic iron overload leads to a profound autophagy defect through mTORC1-UVRAG inhibition and provides new mechanistic insight into metabolic syndrome-associated insulin resistance.
C1 [Jahng, James Won Suk; Palanivel, Rengasamy; Song, Erfei; Sung, Hye Kyoung; Sweeney, Gary] York Univ, Dept Biol, Toronto, ON, Canada.
   [Alsaadi, Reham Musaibeh; Russell, Ryan Charles] Univ Ottawa, Dept Cellular & Mol Med, Ottawa, ON, Canada.
   [Hipolito, Victoria Emily Barbosa; Botelho, Roberto Jorge] Ryerson Univ, Dept Chem & Biol, Toronto, ON, Canada.
   [Hipolito, Victoria Emily Barbosa; Botelho, Roberto Jorge] Ryerson Univ, Mol Sci Grad Program, Toronto, ON, Canada.
C3 York University - Canada; University of Ottawa; Toronto Metropolitan
   University; Toronto Metropolitan University
RP Sweeney, G (corresponding author), York Univ, Dept Biol, Toronto, ON, Canada.; Russell, RC (corresponding author), Univ Ottawa, Dept Cellular & Mol Med, Ottawa, ON, Canada.
EM ryan.russell@uottawa.ca; gsweeney@yorku.ca
RI Alsaadi, Reham/AAS-6821-2021; RENGASAMY, PALANIVEL/GMW-4099-2022;
   Botelho, Roberto/B-9145-2013
OI Botelho, Roberto/0000-0002-7820-0999; Alsaadi,
   Reham/0000-0003-0136-8803; Russell, Ryan/0000-0003-3364-8869; Jahng, Won
   Suk/0000-0003-2367-6567
FU Canadian Institutes of Health Research (CIHR); Heart & Stroke Foundation
   of Ontario; CIHR [PJT153034]; CIHR Frederick Banting and Charles Best
   Canada Graduate Scholarship
FX GS acknowledges support from Canadian Institutes of Health Research
   (CIHR) and a Career Investigator Award from Heart & Stroke Foundation of
   Ontario. RCR also acknowledges support from CIHR (#PJT153034). JWSJ is a
   recipient of CIHR Frederick Banting and Charles Best Canada Graduate
   Scholarship. We greatly appreciate Dr.s' James R Connor and Stephanie
   Patton, Penn State Hershey Medical Center for providing IRE-CFP reporter
   and Dr Christopher J. Chang, University of California Berkeley for
   providing IP-1 probe.
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NR 68
TC 66
Z9 76
U1 0
U2 18
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1469-221X
EI 1469-3178
J9 EMBO REP
JI EMBO Rep.
PD OCT 4
PY 2019
VL 20
IS 10
AR e47911
DI 10.15252/embr.201947911
EA AUG 2019
PG 18
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA JC0KS
UT WOS:000483203300001
PM 31441223
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Kitsiou-Tzeli, S
   Tzetis, M
AF Kitsiou-Tzeli, Sofia
   Tzetis, Maria
TI Maternal epigenetics and fetal and neonatal growth
SO CURRENT OPINION IN ENDOCRINOLOGY DIABETES AND OBESITY
LA English
DT Review
DE imprinted genes; intrauterine growth restriction (IUGR); low infant
   birth weight; maternal epigenetics; metabolic syndrome
ID DNA METHYLATION; OBESITY; MECHANISMS; EXPRESSION; EVOLUTION; EXPOSURE;
   SMOKING; WEIGHT; IMPACT; GENES
AB Purpose of review
   The article provides an update on new insights of factors altering inherited maternal epigenome that ultimately affect fetal and neonatal growth.
   Recent findings
   A number of new publications have identified mechanisms through which maternal nutrition, environmental exposures such as stress and toxic substances altering expression of imprinted genes during pregnancy can influence fetal and neonatal phenotype and susceptibility to disease development later in life. The possible causes of metabolic syndrome by in-utero epigenetic alterations of genes involved in energy metabolism (PPAR gamma and PPAR alpha), microRNAs, arginine methyltransferases, lysine demethylases, and histone deacetylaces have been elucidated. Moreover associations between methylation of key genes (NRC31, HSD11 beta 1/2, GFI1) involved in the hypothalamic-pituitary-adrenal axis have been identified. Alcohol exposure during pregnancy was found to alter methylation patterns of several imprinted genes (H19, SLC22A18, SLC6A3, DRD4). Finally alterations in vulnerable epigenetic marks of imprinted genes such as H19/IGF2, during early stages of embryonic development result in intrauterine growth restriction.
   Summary
   All these investigations continue to provide new insights for improved clinical management of in-utero development.
C1 [Kitsiou-Tzeli, Sofia; Tzetis, Maria] Natl & Kapodistrian Univ Athens, Dept Med Genet, Sch Med, Athens, Greece.
C3 National & Kapodistrian University of Athens; Athens Medical School
RP Kitsiou-Tzeli, S (corresponding author), Natl & Kapodistrian Univ Athens, Dept Med Genet, Sch Med, Aghia Sophia Childrens Hosp, Athens 11527, Greece.
EM skitsiou@med.uoa.gr
RI Tzetis, Maria/K-5220-2012
OI Tzetis, Maria/0000-0002-6810-2922
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NR 29
TC 63
Z9 65
U1 0
U2 58
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1752-296X
EI 1752-2978
J9 CURR OPIN ENDOCRINOL
JI Curr. Opin. Endocrinol. Diabetes Obes.
PD FEB
PY 2017
VL 24
IS 1
BP 43
EP 46
DI 10.1097/MED.0000000000000305
PG 4
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA EI0NS
UT WOS:000392171800010
PM 27898587
DA 2025-06-11
ER

PT J
AU Medina, J
   Fernández-Salazar, LI
   García-Buey, L
   Moreno-Otero, R
AF Medina, J
   Fernández-Salazar, LI
   García-Buey, L
   Moreno-Otero, R
TI Approach to the pathogenesis and treatment of nonalcoholic
   steatohepatitis
SO DIABETES CARE
LA English
DT Review
ID TUMOR-NECROSIS-FACTOR; FATTY LIVER-DISEASE; HEPATIC CYTOCHROME-P450 2E1;
   INDUCED INSULIN-RESISTANCE; FACTOR-ALPHA; BODY-WEIGHT; MITOCHONDRIAL
   DYSFUNCTION; URSODEOXYCHOLIC ACID; METABOLIC SYNDROME; IRON OVERLOAD
AB Nonalcoholic steatohepatitis (NASH) represents art advanced stage of fatty liver disease developed in the absence of alcohol abuse. Its increasing prevalence in western countries, the diagnostic difficulties by noninvasive tests, and the possibility of progression to advanced fibrosis and even cirrhosis make NASH a challenge for hepatologists. NASH is frequently associated with type 2 diabetes and the metabolic syndrome, and several genetic and acquired factors are involved in its pathogenesis. Insulin resistance plays a central role in the development of a steatotic liver which becomes vulnerable to additional injuries. Several cyclic mechanisms leading to self-enhancement of insulin resistance and hepatic accumulation of fat have been recently identified. Excess intracellular fatty acids, oxidant stress, tumor necrosis factor-alpha, and mitochondrial dysfunction arc causes of hepatocellular injury, thereby leading to disease progression and to the establishment of NASH. Intestinal bacterial overgrowth also plays a role, by increasing production of endogenous ethanol and proinflammatory Cytokines. Therapeutic strategies aimed It modulating insulin resistance, normalizing lipoprotein metabolism, and downregulating inflammatory mediators with probiotics have promising potential.
C1 Autonomous Univ Madrid, Univ Hosp La Princesa, Liver Unit, E-28049 Madrid, Spain.
   Univ Hosp, Digest Dis Serv, Valladolid, Spain.
C3 Autonomous University of Madrid
RP Hosp Univ Princesa, Unidad Hepatol, Planta 3,Diego Leon 62, E-28006 Madrid, Spain.
EM rmoreno.hlpr@salud.madrid.org
RI Medina, Jesus/J-4785-2015; Fernández Salazar, Luis/GLN-5812-2022
OI Fernandez-Salazar, Luis/0000-0002-9951-7979
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NR 123
TC 161
Z9 192
U1 1
U2 5
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0149-5992
EI 1935-5548
J9 DIABETES CARE
JI Diabetes Care
PD AUG
PY 2004
VL 27
IS 8
BP 2057
EP 2066
DI 10.2337/diacare.27.8.2057
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 842TD
UT WOS:000223026200035
PM 15277442
OA Bronze
DA 2025-06-11
ER

PT J
AU Pitsillou, E
   Liang, JL
   Hung, A
   Karagiannis, TC
AF Pitsillou, Eleni
   Liang, Julia
   Hung, Andrew
   Karagiannis, Tom C.
TI The circadian machinery links metabolic disorders and depression: A
   review of pathways, proteins and potential pharmacological interventions
SO LIFE SCIENCES
LA English
DT Review
DE Circadian rhythm; Central circadian clock; Clock proteins; Epigenetic
   modifications; Metabolic disorders; Major depressive disorder
ID SMALL-MOLECULE INHIBITOR; ELEMENT-BINDING PROTEIN; D-ASPARTATE
   RECEPTORS; SLEEP-PHASE SYNDROME; X-RAY-STRUCTURE; HIGH-FAT DIET; HISTONE
   DEMETHYLASE; INSULIN-RESISTANCE; BLUE-LIGHT; SUPRACHIASMATIC NUCLEUS
AB Circadian rhythms are responsible for regulating a number of physiological processes. The central oscillator is located within the suprachiasmatic nucleus (SCN) of the hypothalamus and the SCN synchronises the circadian clocks that are found in our peripheral organs through neural and humoral signalling. At the molecular level, biological clocks consist of transcription-translation feedback loops (TTFLs) and these pathways are influenced by transcription factors, post-translational modifications, signalling pathways and epigenetic modifiers. When disruptions occur in the circadian machinery, the activities of the proteins implicated in this network and the expression of core clock or clock-controlled genes (CCGs) can be altered. Circadian misalignment can also arise when there is desychronisation between our internal clocks and environmental stimuli.
   There is evidence in the literature demonstrating that disturbances in the circadian rhythm contribute to the pathophysiology of several diseases and disorders. This includes the metabolic syndrome and recently, it has been suggested that the 'circadian syndrome' may be a more appropriate term to use to not only describe the cardio-metabolic risk factors but also the associated comorbidities. Here we overview the molecular architecture of circadian clocks in mammals and provide insight into the effects of shift work, exposure to artificial light, food intake and stress on the circadian rhythm. The relationship between circadian rhythms, metabolic disorders and depression is reviewed and this is a topic that requires further investigation. We also describe how particular proteins involved in the TTFLs can be potentially modulated by small molecules, including pharmacological interventions and dietary compounds.
C1 [Pitsillou, Eleni; Liang, Julia; Karagiannis, Tom C.] Monash Univ, Cent Clin Sch, Dept Diabet, Epigen Med, Melbourne, Vic 3004, Australia.
   [Pitsillou, Eleni; Liang, Julia; Hung, Andrew] RMIT Univ, Coll Sci Engn & Hlth, Sch Sci, Melbourne, Vic 3001, Australia.
   [Karagiannis, Tom C.] Univ Melbourne, Dept Clin Pathol, Parkville, Vic 3052, Australia.
C3 Monash University; Royal Melbourne Institute of Technology (RMIT);
   University of Melbourne
RP Karagiannis, TC (corresponding author), Monash Univ, Cent Clin Sch, Dept Diabet, Epigen Med Program, Melbourne, Vic 3004, Australia.
EM tom.karagiannis@monash.edu
RI ; Liang, Julia J/LKM-6635-2024
OI Hung, Andrew/0000-0003-3569-2951; Liang, Julia J/0000-0002-3031-3169;
   Karagiannis, Tom/0000-0002-9967-1546
FU McCord Research (Iowa, USA); Australian Government Research Training
   Program Scholarship
FX We would like to acknowledge intellectual and financial support by
   McCord Research (Iowa, USA). JL is supported by an Australian Government
   Research Training Program Scholarship. Several of the figures were
   created with BioRender.com.
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NR 324
TC 13
Z9 13
U1 4
U2 31
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0024-3205
EI 1879-0631
J9 LIFE SCI
JI Life Sci.
PD JAN 15
PY 2021
VL 265
AR 118809
DI 10.1016/j.lfs.2020.118809
PG 16
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA PN4DK
UT WOS:000604430800062
PM 33249097
DA 2025-06-11
ER

PT J
AU Silhavy, J
   Mlejnek, P
   Simáková, M
   Malínská, H
   Marková, I
   Hüttl, M
   Miklánková, D
   Kazdová, L
   Vrbacky, M
   Pecinová, A
   Mrácek, T
   Pravenec, M
AF Silhavy, Jan
   Mlejnek, Petr
   Simakova, Miroslava
   Malinska, Hana
   Markova, Irena
   Huttl, Martina
   Miklankova, Denisa
   Kazdova, Ludmila
   Vrbacky, Marek
   Pecinova, Alena
   Mracek, Tomas
   Pravenec, Michal
TI Hypolipidemic Effects of Beetroot Juice in SHR-CRP and HHTg Rat Models
   of Metabolic Syndrome: Analysis of Hepatic Proteome
SO METABOLITES
LA English
DT Article
DE spontaneously hypertensive rat; hereditary hypertriglyceridemic rat;
   beetroot; lipids; proteomics; glycerophospholipid metabolism; mTOR
   signalling
ID BETA-VULGARIS L.; IDENTIFICATION; CHOLESTEROL; DEFICIENT; NITRATE;
   TARGET
AB Recently, red beetroot has attracted attention as a health-promoting functional food. Studies have shown that beetroot administration can reduce blood pressure and ameliorate parameters of glucose and lipid metabolism; however, mechanisms underlying these beneficial effects of beetroot are not yet fully understood. In the current study, we analysed the effects of beetroot on parameters of glucose and lipid metabolism in two models of metabolic syndrome: (i) transgenic spontaneously hypertensive rats expressing human C-reactive protein (SHR-CRP rats), and (ii) hereditary hypertriglyceridemic (HHTg) rats. Treatment with beetroot juice for 4 weeks was, in both models, associated with amelioration of oxidative stress, reduced circulating lipids, smaller visceral fat depots, and lower ectopic fat accumulation in the liver compared to the respective untreated controls. On the other hand, beetroot treatment had no significant effects on the sensitivity of the muscle and adipose tissue to insulin action in either model. Analyses of hepatic proteome revealed significantly deregulated proteins involved in glycerophospholipid metabolism, mTOR signalling, inflammation, and cytoskeleton rearrangement.
C1 [Silhavy, Jan; Mlejnek, Petr; Simakova, Miroslava; Vrbacky, Marek; Pecinova, Alena; Mracek, Tomas; Pravenec, Michal] Czech Acad Sci, Inst Physiol, Prague, Czech Republic.
   [Malinska, Hana; Markova, Irena; Huttl, Martina; Miklankova, Denisa; Kazdova, Ludmila] Inst Clin & Expt Med, Ctr Expt Med, Prague 14021, Czech Republic.
C3 Czech Academy of Sciences; Institute of Physiology of the Czech Academy
   of Sciences; Institute for Clinical & Experimental Medicine (IKEM)
RP Silhavy, J (corresponding author), Czech Acad Sci, Inst Physiol, Prague, Czech Republic.
EM jan.silhavy@fgu.cas.cz
RI Silhavy, Jan/B-5292-2014; Simakova, Miroslava/R-5367-2019; Mracek,
   Tomas/C-5003-2012; Mlejnek, Petr/C-2305-2012; Pravenec,
   Michal/B-1666-2012; Pecinova, Alena/A-8695-2010
OI Pravenec, Michal/0000-0001-9197-5871; Malinska,
   Hana/0000-0002-9076-3399; Kazdova, Ludmila/0000-0003-0563-0186; Markova,
   Irena/0000-0002-4331-7636; Pecinova, Alena/0000-0002-0204-7502
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NR 57
TC 3
Z9 3
U1 0
U2 11
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2218-1989
J9 METABOLITES
JI Metabolites
PD FEB
PY 2023
VL 13
IS 2
AR 192
DI 10.3390/metabo13020192
PG 16
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 9J3JQ
UT WOS:000940087900001
PM 36837811
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Kakarala, CL
   Hassan, M
   Belavadi, R
   Gudigopuram, SVR
   Raguthu, CC
   Gajjela, H
   Kela, I
   Sange, I
AF Kakarala, Chandra L.
   Hassan, Mohammad
   Belavadi, Rishab
   Gudigopuram, Sri Vallabh Reddy
   Raguthu, Ciri C.
   Gajjela, Harini
   Kela, Iljena
   Sange, Ibrahim
TI Beyond the Skin Plaques: Psoriasis and Its Cardiovascular Comorbidities
SO CUREUS JOURNAL OF MEDICAL SCIENCE
LA English
DT Review
DE anti-tumor-necrosis factor-alpha; anti-il12/23; systemic inflammation;
   cardiovascular risk; cardiovascular disease; psoriasis
ID CORONARY-ARTERY-DISEASE; DIABETES-MELLITUS; IMMUNE-SYSTEM; ENDOTHELIAL
   DYSFUNCTION; METABOLIC SYNDROME; VASCULAR-DISEASES; OXIDATIVE STRESS;
   INCREASED RISK; HYPERTENSION; INFLAMMATION
AB Psoriasis, a widely prevalent chronic disease of the skin and joints, has long been associated with farreaching systemic ramifications and decreased quality of life. However, psoriasis is largely underdiagnosed and insufficiently treated. Classical risk factors predisposing to cardiovascular diseases, such as hypertension, diabetes, metabolic syndrome, and dyslipidemia, have been noted in patients with mild and severe psoriasis. Furthermore, the magnitude of the cardiovascular comorbidity and the need to screen for risk factors has often been ignored while considering the management options for psoriasis. This article has reviewed the cardiovascular implications of psoriasis from the shared pathogenesis behind these two diseases to the increased incidence of cardiovascular events, such as myocardial infarction, stroke, and other causes of vascular mortality. Additionally, the therapeutic targets of common inflammatory pathways, such as those involving tumor necrosis factor alpha (TNF-alpha), interleukin-12/interleukin-23 (IL-12/IL-23), and helper T cells 17 (Th17), have been discussed with an emphasis on their efficacy in controlling psoriasis and its cardiovascular consequences.
C1 [Kakarala, Chandra L.] Jawaharlal Inst Postgrad Med Educ & Res JIPMER, Internal Med, Pondicherry, India.
   [Hassan, Mohammad] Mohi Ud Din Islamic Med Coll, Internal Med, Mirpur, Pakistan.
   [Belavadi, Rishab] Jawaharlal Inst Postgrad Med Educ & Res JIPMER, Surg, Pondicherry, India.
   [Gudigopuram, Sri Vallabh Reddy] Our Lady Fatima Univ, Coll Med, Res, Hyderabad, India.
   [Raguthu, Ciri C.] Tianjin Med Univ, Res, Tianjin, Peoples R China.
   [Gajjela, Harini] Our Lady Fatima Univ, Coll Med, Res, Valenzuela, Poland.
   [Kela, Iljena] Jagiellonian Univ, Coll Med, Family Med, Krakow, Poland.
   [Sange, Ibrahim] Calif Inst Behav Neurosci & Psychol, Res, Fairfield, CT USA.
   [Sange, Ibrahim] KJ Somaiya Med Coll, Res, Mumbai, Maharashtra, India.
C3 Jawaharlal Institute of Postgraduate Medical Education & Research;
   Jawaharlal Institute of Postgraduate Medical Education & Research;
   Tianjin Medical University; Jagiellonian University; Collegium Medicum
   Jagiellonian University
RP Kakarala, CL (corresponding author), Jawaharlal Inst Postgrad Med Educ & Res JIPMER, Internal Med, Pondicherry, India.
EM kakarala.lalita@gmail.com
OI Kakarala, Chandra/0000-0003-0223-3118; Hassan,
   Mohammad/0000-0003-4973-7655
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NR 85
TC 11
Z9 11
U1 0
U2 2
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
EI 2168-8184
J9 CUREUS J MED SCIENCE
JI Cureus J Med Sci
PD NOV 17
PY 2021
VL 13
IS 11
AR e19679
DI 10.7759/cureus.19679
PG 12
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA XD2FM
UT WOS:000722525700008
PM 34976467
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Kalupahana, NS
   Claycombe, KJ
   Moustaid-Moussa, N
AF Kalupahana, Nishan S.
   Claycombe, Kate J.
   Moustaid-Moussa, Naima
TI (n-3) Fatty Acids Alleviate Adipose Tissue Inflammation and Insulin
   Resistance: Mechanistic Insights
SO ADVANCES IN NUTRITION
LA English
DT Review
AB Obesity is associated with the metabolic syndrome, a significant risk factor for developing type 2 diabetes and cardiovascular diseases. Chronic low-grade inflammation occurring in the adipose tissue of obese individuals is causally linked to the pathogenesis of insulin resistance and the metabolic syndrome. Although the exact trigger of this inflammatory process is unknown, adipose tissue hypoxia, endoplasmic reticular stress, and saturated fatty acid mediated activation of innate immune processes have been identified as important processes in these disorders. Furthermore, macrophages and T lymphocytes have important roles in orchestrating this immune process. Although energy restriction leading to weight loss is the primary dietary intervention to reverse these obesity-associated metabolic disorders, other interventions targeted at alleviating adipose tissue inflammation have not been explored in detail. In this regard, (n-3) PUFA of marine origin both prevent and reverse high-fat-diet induced adipose tissue inflammation and insulin resistance in rodents. We provide an update on the pathogenesis of adipose tissue inflammation and insulin resistance in obesity and discuss potential mechanisms by which (n-3) PUFA prevent and reverse these changes and the implications in human health. Adv. Nutr. 2: 304-316, 2011.
C1 [Kalupahana, Nishan S.; Moustaid-Moussa, Naima] Univ Tennessee, Obes Res Ctr, Knoxville, TN 37996 USA.
   [Kalupahana, Nishan S.; Moustaid-Moussa, Naima] Dept Anim Sci, Knoxville, TN 37996 USA.
   [Moustaid-Moussa, Naima] UT Extens Family & Consumer Sci Dept, Knoxville, TN 37996 USA.
   [Kalupahana, Nishan S.] Univ Peradeniya, Fac Med, Dept Physiol, Peradeniya 20400, Sri Lanka.
   [Claycombe, Kate J.] USDA ARS, Grand Forks Human Nutr Res Ctr, Grand Forks, ND 58201 USA.
C3 University of Tennessee System; University of Tennessee Knoxville;
   University of Tennessee System; University of Tennessee Knoxville; UT
   Institute of Agriculture; University of Tennessee System; University of
   Tennessee Knoxville; UT Institute of Agriculture; University of
   Peradeniya; United States Department of Agriculture (USDA)
RP Moustaid-Moussa, N (corresponding author), Univ Tennessee, Obes Res Ctr, Knoxville, TN 37996 USA.
EM moustaid@utk.edu
RI Kalupahana, Nishan/E-1913-2011; Moustaid-Moussa, Naima/B-9067-2014
FU National Institute of Food and Agriculture-National Research Initiative
   award [2005-35200-15224]; AHA Southeast Affiliate Predoctoral
   Fellowship; University of Tennessee (UT) Obesity Research Center; UT
   AgResearch; UT Extension
FX Supported by a National Institute of Food and Agriculture-National
   Research Initiative award (2005-35200-15224), an AHA Southeast Affiliate
   Predoctoral Fellowship, the University of Tennessee (UT) Obesity
   Research Center, UT AgResearch, and UT Extension.
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NR 155
TC 230
Z9 256
U1 2
U2 43
PU AMER SOC NUTRITION-ASN
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 2161-8313
EI 2156-5376
J9 ADV NUTR
JI Adv. Nutr.
PD JUL
PY 2011
VL 2
IS 4
BP 304
EP 316
DI 10.3945/an.111.000505
PG 13
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA V27BT
UT WOS:000208589400002
PM 22332072
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Hijová, E
AF Hijova, Emilia
TI Synbiotic Supplements in the Prevention of Obesity and Obesity-Related
   Diseases
SO METABOLITES
LA English
DT Review
DE obesity; synbiotics; gut microbiota; type 2 diabetes mellitus; metabolic
   syndrome
ID GUT MICROBIOTA; METABOLIC SYNDROME; DIABETIC-PATIENTS; LIPID PROFILES;
   DOUBLE-BLIND; INSULIN METABOLISM; OXIDATIVE STRESS; RISK-FACTORS;
   BODY-WEIGHT; PROBIOTICS
AB Obesity and being overweight have reached incredible proportions worldwide and are one of the most common human health problems. The causes of obesity are multifactorial, including a complex interplay among genes, metabolism, diet, physical activity, and the environment. The intestinal microbiota has the ability to affect the host physiology for both benefit and damage, either directly or through microbial metabolites. The aim of this review is to discuss the mechanisms by which the intestinal microbiota could act as a key modifier of obesity and related metabolic abnormalities. The synbiotic components provide an optimal target for modulation of the intestinal microbiota and help reshape the metabolic profile in obese people. The development of novel functional foods containing synbiotic ingredients may present a support in the prevention of obesity as one of the risk factors for chronic diseases. Knowledge of the synbiotic mechanisms of action and the use of new functional foods supplemented with probiotics and prebiotics will facilitate the clinical application and development of individual health care strategies.
C1 [Hijova, Emilia] Pavol Jozef Safarik Univ, Ctr Clin & Preclin Res MEDIPARK, Dept Expt Med, Fac Med, Kosice 04011, Slovakia.
C3 University of Pavol Jozef Safarik Kosice
RP Hijová, E (corresponding author), Pavol Jozef Safarik Univ, Ctr Clin & Preclin Res MEDIPARK, Dept Expt Med, Fac Med, Kosice 04011, Slovakia.
EM emilia.hijova@upjs.sk
OI Hijova, Emilia/0000-0002-8259-373X
FU Operational Program Integrated Infrastructure within the project:
   Functional Foods for Healthy Life [ITMS 2014+ 313012T288]; European
   Regional Development Fund; Demand-driven research for sustainable and
   innovative food, Drive4SIFood [313011V336]
FX This work was supported by the Operational Program Integrated
   Infrastructure within the project: Functional Foods for Healthy Life
   with ITMS 2014+ 313012T288 and Demand-driven research for sustainable
   and innovative food, Drive4SIFood 313011V336, co-financed by the
   European Regional Development Fund.
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NR 94
TC 17
Z9 17
U1 1
U2 21
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2218-1989
J9 METABOLITES
JI Metabolites
PD APR
PY 2022
VL 12
IS 4
AR 313
DI 10.3390/metabo12040313
PG 16
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 0S1LQ
UT WOS:000786043500001
PM 35448499
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Calle, MC
   Fernandez, ML
AF Calle, M. C.
   Fernandez, M. L.
TI Inflammation and type 2 diabetes
SO DIABETES & METABOLISM
LA English
DT Review
DE TNF-alpha; C-reactive protein; Adiponectin; Weight loss; Diet;
   Cardiovascular diseases; Type 2 diabetes; The metabolic syndrome
ID C-REACTIVE PROTEIN; TUMOR-NECROSIS-FACTOR; ADIPONECTIN GENE-EXPRESSION;
   ENDOPLASMIC-RETICULUM STRESS; ADIPOSE-SPECIFIC PROTEIN;
   INSULIN-RESISTANCE; WEIGHT-LOSS; FACTOR-ALPHA; DIETARY PATTERNS;
   ENDOTHELIAL DYSFUNCTION
AB Low-grade inflammation is a common feature in subjects with type 2 diabetes (T2D). Heart disease, the metabolic syndrome and T2D all have in common the increased concentration of circulatory cytokines as a result of inflammation. Inflammatory cytokines are produced by different cell types and secreted into the circulation, where they regulate different tissues through their local, central and peripheral actions. This review focuses on C-reactive protein (CRP), a well-established marker of the development of inflammation, on tumour necrosis factor (TNF)-alpha, an inflammatory marker strongly associated with diabetes, and on adiponectin, a cytokine produced by adipose tissue and associated with insulin sensitivity. While it is clear from the literature that these cytokines play a major role in the development of T2D or, in the case of adiponectin, its prevention, the best strategy for favourably altering the inflammatory response is still a matter of debate. (C) 2012 Elsevier Masson SAS. All rights reserved.
C1 [Calle, M. C.; Fernandez, M. L.] Univ Connecticut, Dept Nutr Sci, Storrs, CT 06269 USA.
C3 University of Connecticut
RP Fernandez, ML (corresponding author), Univ Connecticut, Dept Nutr Sci, 3624 Horsebarn Rd,Ext U-4017, Storrs, CT 06269 USA.
EM maria-luz.fernandez@uconn.edu
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NR 93
TC 375
Z9 419
U1 1
U2 46
PU MASSON EDITEUR
PI MOULINEAUX CEDEX 9
PA 21 STREET CAMILLE DESMOULINS, ISSY, 92789 MOULINEAUX CEDEX 9, FRANCE
SN 1262-3636
EI 1878-1780
J9 DIABETES METAB
JI Diabetes Metab.
PD JUN
PY 2012
VL 38
IS 3
BP 183
EP 191
DI 10.1016/j.diabet.2011.11.006
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 987QC
UT WOS:000307431200001
PM 22252015
DA 2025-06-11
ER

PT J
AU Charlebois, E
   Pantopoulos, K
AF Charlebois, Edouard
   Pantopoulos, Kostas
TI Nutritional Aspects of Iron in Health and Disease
SO NUTRIENTS
LA English
DT Review
DE iron deficiency; iron overload; anemia; heme; metabolic syndrome;
   cardiovascular disease; cancer; microbiome
ID SOLUBLE TRANSFERRIN RECEPTOR; SERUM FERRITIN CONCENTRATION;
   DOSE-RESPONSE METAANALYSIS; HEPATIC GLUCOSE-PRODUCTION;
   CORONARY-HEART-DISEASE; HEME IRON; INSULIN-RESISTANCE; DEFICIENCY
   ANEMIA; OXIDATIVE STRESS; GUT MICROBIOTA
AB Dietary iron assimilation is critical for health and essential to prevent iron-deficient states and related comorbidities, such as anemia. The bioavailability of iron is generally low, while its absorption and metabolism are tightly controlled to satisfy metabolic needs and prevent toxicity of excessive iron accumulation. Iron entry into the bloodstream is limited by hepcidin, the iron regulatory hormone. Hepcidin deficiency due to loss-of-function mutations in upstream gene regulators causes hereditary hemochromatosis, an endocrine disorder of iron overload characterized by chronic hyperabsorption of dietary iron, with deleterious clinical complications if untreated. The impact of high dietary iron intake and elevated body iron stores in the general population is not well understood. Herein, we summarize epidemiological data suggesting that a high intake of heme iron, which is abundant in meat products, poses a risk factor for metabolic syndrome pathologies, cardiovascular diseases, and some cancers. We discuss the clinical relevance and potential limitations of data from cohort studies, as well as the need to establish causality and elucidate molecular mechanisms.
C1 [Charlebois, Edouard; Pantopoulos, Kostas] Jewish Gen Hosp, Lady Davis Inst Med Res, Montreal, PQ H3T 1E2, Canada.
   [Charlebois, Edouard; Pantopoulos, Kostas] McGill Univ, Dept Med, Montreal, PQ H4A 3J1, Canada.
C3 Jewish General Hospital - Montreal; Lady Davis Institute; McGill
   University
RP Pantopoulos, K (corresponding author), Jewish Gen Hosp, Lady Davis Inst Med Res, Montreal, PQ H3T 1E2, Canada.; Pantopoulos, K (corresponding author), McGill Univ, Dept Med, Montreal, PQ H4A 3J1, Canada.
EM edouard.charlebois@mail.mcgill.ca; kostas.pantopoulos@mcgill.ca
OI Charlebois, Edouard/0000-0002-1872-3528
FU Canadian Institutes of Health Research (CIHR) [PJT-486651]; Natural
   Sciences and Engineering Research Council of Canada (NSERC); Fonds de
   recherche du Quebec-Sante (FRQS)
FX This research was funded by the Canadian Institutes of Health Research
   (CIHR; PJT-486651). EC was funded by fellowships from the Natural
   Sciences and Engineering Research Council of Canada (NSERC) and from the
   Fonds de recherche du Quebec-Sante (FRQS).
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NR 134
TC 43
Z9 44
U1 5
U2 19
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD MAY 24
PY 2023
VL 15
IS 11
AR 2441
DI 10.3390/nu15112441
PG 15
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA I9BX5
UT WOS:001005672700001
PM 37299408
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Leisegang, K
   Sengupta, P
   Agarwal, A
   Henkel, R
AF Leisegang, Kristian
   Sengupta, Pallav
   Agarwal, Ashok
   Henkel, Ralf
TI Obesity and male infertility: Mechanisms and management
SO ANDROLOGIA
LA English
DT Review
DE male infertility; metabolic syndrome; obesity; semen quality
ID BODY-MASS INDEX; MALE REPRODUCTIVE FUNCTION; GERM-CELL APOPTOSIS;
   METABOLIC SYNDROME; MALE-FERTILITY; SEMEN QUALITY; TESTICULAR
   MORPHOLOGY; BARIATRIC SURGERY; LEPTIN; TESTOSTERONE
AB Obesity is considered a global health problem affecting more than a third of the population. Complications of obesity include cardiovascular diseases, type 2 diabetes mellitus, malignancy (including prostatic cancer), neurodegeneration and accelerated ageing. In males, these further include erectile dysfunction, poor semen quality and subclinical prostatitis. Although poorly understood, important mediators of obesity that may influence the male reproductive system include hyperinsulinemia, hyperleptinemia, chronic inflammation and oxidative stress. Obesity is known to disrupt male fertility and the reproduction potential, particularly through alteration in the hypothalamic-pituitary-gonadal axis, disruption of testicular steroidogenesis and metabolic dysregulation, including insulin, cytokines and adipokines. Importantly, obesity and its underlying mediators result in a negative impact on semen parameters, including sperm concentration, motility, viability and normal morphology. Moreover, obesity inhibits chromatin condensation, DNA fragmentation, increases apoptosis and epigenetic changes that can be transferred to the offspring. This review discusses the impact of obesity on the male reproductive system and fertility, including associated mechanisms. Furthermore, weight management strategies, lifestyle changes, prescription medication, and complementary and alternative medicine in the management of obesity-induced subfertility is discussed.
C1 [Leisegang, Kristian] Univ Western Cape, Sch Nat Med, Cape Town, South Africa.
   [Sengupta, Pallav] MAHSA Univ, Dept Physiol, Fac Med Biosci & Nursing, Jenjarom, Selangor, Malaysia.
   [Agarwal, Ashok; Henkel, Ralf] Cleveland Clin, Amer Ctr Reprod Med, Cleveland, OH 44106 USA.
   [Henkel, Ralf] Univ Western Cape, Dept Med Biosci, Cape Town, South Africa.
C3 University of the Western Cape; Mahsa University; Cleveland Clinic
   Foundation; University of the Western Cape
RP Leisegang, K (corresponding author), Univ Western Cape, Sch Nat Med, Cape Town, South Africa.
EM kleisegang@uwc.ac.za
RI Leisegang, Kristian/AAS-3925-2021; Sengupta, Pallav/E-3392-2016
OI Sengupta, Pallav/0000-0002-1928-5048; Henkel, Ralf/0000-0003-1128-2982;
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NR 125
TC 176
Z9 184
U1 6
U2 23
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0303-4569
EI 1439-0272
J9 ANDROLOGIA
JI Andrologia
PD FEB
PY 2021
VL 53
IS 1
SI SI
AR e13617
DI 10.1111/and.13617
EA MAY 2020
PG 14
WC Andrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA PZ8AA
UT WOS:000531805400001
PM 32399992
DA 2025-06-11
ER

PT J
AU Lakkis, JI
   Weir, MR
AF Lakkis, Jay I.
   Weir, Mathew R.
TI Obesity and Kidney Disease
SO PROGRESS IN CARDIOVASCULAR DISEASES
LA English
DT Review
DE Obesity; Chronic kidney disease; Metabolic syndrome;
   Metabolically-healthy obesity; Obesity-related hypertension; Leptin;
   Adiponectin
ID OBSTRUCTIVE SLEEP-APNEA; BODY-MASS INDEX; ANGIOTENSIN-ALDOSTERONE
   SYSTEM; METABOLICALLY HEALTHY OBESITY; CLINICAL-PRACTICE GUIDELINE;
   DIETARY-SODIUM RESTRICTION; FATTY-ACID OXIDATION; GUT-BRAIN AXIS;
   ADIPOSE-TISSUE; RESISTANT HYPERTENSION
AB Obesity is a systemic disease of the white adipose tissue, which has evolved into a global epidemic. It is associated with a plethora of adipocyte hormonal (adipokine) imbalances, dysregulation of the energy-balance system, imbalances in metabolic homeostasis, a pro-inflammatory state and multiple target organ damages. Clinically, the obesity phenotype is not homogenous and is more likely to represent a spectrum with varying degrees of metabolic un-health; metabolically-unhealthy obesity is often a part of the metabolic syndrome. The links between obesity and chronic kidney disease are numerous, bidirectional, multi-layered and complex; this complexity may be explained by shared pathophysiological pathways (e.g. chronic inflammation, increased oxidative stress, and hyper-insulinemia), shared clusters of risk factors as well as associated diseases (e.g. insulin resistance, hypertension and dyslipidemia). We will review these links and their clinical manifestations, and offer a summary of available non-pharmacological as well as pharmacological therapeutic strategies. (C) 2018 Elsevier Inc. All rights reserved.
C1 [Lakkis, Jay I.] Univ Hawaii, John A Burns Sch Med, 95 Maui Lani Pkwy, Wailuku, HI 96793 USA.
   [Weir, Mathew R.] Univ Maryland, Sch Med, Div Nephrol, 22 S Greene St,Room N3W143, Baltimore, MD 21201 USA.
C3 University System of Maryland; University of Maryland Baltimore
RP Weir, MR (corresponding author), Univ Maryland, Sch Med, Div Nephrol, 22 S Greene St,Room N3W143, Baltimore, MD 21201 USA.
EM mweir@medicine.umaryland.edu
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NR 170
TC 115
Z9 126
U1 0
U2 15
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0033-0620
EI 1873-1740
J9 PROG CARDIOVASC DIS
JI Prog. Cardiovasc. Dis.
PD JUL-AUG
PY 2018
VL 61
IS 2
BP 157
EP 167
DI 10.1016/j.pcad.2018.07.005
PG 11
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA GU1VN
UT WOS:000445055400009
PM 29981350
DA 2025-06-11
ER

PT J
AU Nartea, R
   Mitoiu, BI
   Ghiorghiu, I
AF Nartea, Roxana
   Mitoiu, Brindusa Ilinca
   Ghiorghiu, Ioana
TI The Link between Magnesium Supplements and Statin Medication in
   Dyslipidemic Patients
SO CURRENT ISSUES IN MOLECULAR BIOLOGY
LA English
DT Review
DE magnesium supplements; metabolic syndrome; lipoproteins; statin
   medication; dyslipidemia
ID CHRONIC KIDNEY-DISEASE; CARDIOVASCULAR RISK-FACTORS; TYPE-2
   DIABETES-MELLITUS; METABOLIC SYNDROME; SERUM MAGNESIUM; DOUBLE-BLIND;
   INSULIN-RESISTANCE; DIETARY MAGNESIUM; OXIDATIVE STRESS; BLOOD-PRESSURE
AB Many investigations have discovered a connection between statins and magnesium supplements. On one hand, increasing research suggests that chronic hypomagnesemia may be an important factor in the etiology of some metabolic illnesses, including obesity and overweight, insulin resistance and type 2 diabetes mellitus, hypertension, alterations in lipid metabolism, and low-grade inflammation. Chronic metabolic problems seem to be prevented by a high Mg intake combined with diet and/or supplements. On the other hand, it is known that statins lower the frequency of cardiac events, stroke, and mortality, not by lowering LDL-C, but by the capacity to reduce mevalonate formation. That will enhance endothelial function, inhibit vascular smooth muscle cell proliferation and migration and encourage macrophages to promote plaque stability and regression while reducing inflammation. Taking these factors into consideration, we did an extensive analysis of the relevant literature, comparing the effects of Mg-2 and statin medications on lipoproteins and, implicitly, on the key enzymes involved in cholesterol metabolism.
C1 [Nartea, Roxana; Mitoiu, Brindusa Ilinca; Ghiorghiu, Ioana] Carol Davila Univ Med & Pharm, Clin Dept 9, Bucharest 050474, Romania.
   [Nartea, Roxana; Ghiorghiu, Ioana] Natl Inst Rehabil Phys Med & Balneoclimatol, Bucharest 030079, Romania.
   [Mitoiu, Brindusa Ilinca] Agrippa Ionescu Clin Emergency Hosp, Bucharest 077016, Romania.
C3 Carol Davila University of Medicine & Pharmacy
RP Mitoiu, BI (corresponding author), Carol Davila Univ Med & Pharm, Clin Dept 9, Bucharest 050474, Romania.; Mitoiu, BI (corresponding author), Agrippa Ionescu Clin Emergency Hosp, Bucharest 077016, Romania.
EM brindusa.mitoiu@umfcd.ro
RI Ilinca, Mitoiu/AAM-4216-2021; Ghiorghiu, Ioana/NBX-1940-2025; Nartea,
   Roxana/AAM-4176-2021
OI Nartea, Roxana/0000-0001-8132-0791; Ghiorghiu, Ioana/0009-0006-3357-5013
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NR 179
TC 10
Z9 10
U1 0
U2 2
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1467-3037
EI 1467-3045
J9 CURR ISSUES MOL BIOL
JI Curr. Issues Mol. Biol.
PD APR
PY 2023
VL 45
IS 4
BP 3146
EP 3167
DI 10.3390/cimb45040205
PG 22
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA F5ZH8
UT WOS:000983120800001
PM 37185729
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Taneja, SK
   Jain, M
   Mandal, R
   Megha, K
AF Taneja, Satish Kumar
   Jain, Mridula
   Mandal, Reshu
   Megha, Kirti
TI Excessive zinc in diet induces leptin resistance in Wistar rat through
   increased uptake of nutrients at intestinal level
SO JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
LA English
DT Article
DE Zinc; Leptin; Insulin; Rat; Intestine
ID METABOLIC SYNDROME-X; PLASMA LEPTIN; OXIDATIVE STRESS; FOOD-INTAKE;
   OBESE; INSULIN; WEIGHT; SUPPLEMENTATION; ENDOCRINE; PHYTATE
AB Project: The ob gene has either been found to be mutant defective resulting in a deficiency of its product leptin or leptin has been found to be resistant to its receptors in obese human and rodents. The factors inducing leptin resistance have not been identified. Since excessive bioavailability of Zn has been implicated in obesity, we investigated if its excess in diet induces leptin resistance.
   Procedure: For the investigations, three groups of Wistar rats were included in this study and they were fed on equicalories semi synthetic basal diet containing 20 mg, 40 mg or 80 mg Zn/kg diet for 120 days. There after they were sacrificed for hormonal status and intestinal investigations.
   Results: The data of this study revealed that the food intake, gain in body weight, serum leptin, glucose, insulin, cortisol increased with increased Zn concentration in diet. TEM study showed a positive correlation between Zn concentration in diet and number of microvilli/unit surface area of the mucosal epithelial cells of the intestine.
   Conclusion: The results of this study suggest that excessive bioavailability of Zn induces leptin resistance through increased uptake of nutrients at intestinal level, leading to the growth of the fat cells which aggravated the leptin synthesis and its release in the blood stream. In spite of its higher circulating level, it was unable to reduce the food intake and gain in body weight in Zn treated rats equivalent to the control group. (C) 2012 Elsevier GmbH. All rights reserved.
C1 [Taneja, Satish Kumar; Jain, Mridula; Mandal, Reshu; Megha, Kirti] Panjab Univ, Dept Zool, Chandigarh 160014, India.
C3 Panjab University
RP Taneja, SK (corresponding author), Panjab Univ, Dept Zool, Chandigarh 160014, India.
EM sktaneja@gmail.com
RI megha, kirti/AAD-2765-2022
OI Megha, Kirti/0000-0001-8830-7987
FU Emeritus Fellowship; University Grant Commission
FX Authors are thankful to Prof. Neelima R. Kumar Chairperson of the
   Department of Zoology, Panjab University Chandigarh for providing
   Laboratory facilities and All India Institute of Medical Sciences (New
   Delhi, India) for Transmission Electron Microscopy. The Emeritus
   Fellowship provided to the senior author Prof. S.K. Taneja by University
   Grant Commission is gratefully acknowledged.
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Z9 25
U1 0
U2 1
PU ELSEVIER GMBH
PI MUNICH
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SN 0946-672X
J9 J TRACE ELEM MED BIO
JI J. Trace Elem. Med. Biol.
PY 2012
VL 26
IS 4
BP 267
EP 272
DI 10.1016/j.jtemb.2012.03.002
PG 6
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 059EL
UT WOS:000312687100009
PM 22683053
DA 2025-06-11
ER

PT J
AU Katsiki, N
   Athyros, VG
   Karagiannis, A
   Mikhailidis, DP
AF Katsiki, Niki
   Athyros, Vasilios G.
   Karagiannis, Asterios
   Mikhailidis, Dimitri P.
TI The Role of Statins in the Treatment of Type 2 Diabetes Mellitus: An
   Update
SO CURRENT PHARMACEUTICAL DESIGN
LA English
DT Article
DE Type 2 diabetes mellitus; dyslipidemia; statin; cardiovascular risk
ID CORONARY-HEART-DISEASE; DENSITY-LIPOPROTEIN-CHOLESTEROL; OBSTRUCTIVE
   SLEEP-APNEA; LOWERING TREATMENT STRATEGIES; CARDIOVASCULAR END-POINTS;
   POST-HOC ANALYSIS; URIC-ACID LEVELS; METABOLIC SYNDROME; GREEK
   ATORVASTATIN; PRIMARY PREVENTION
AB The prevalence of type 2 diabetes mellitus (T2DM) is increasing worldwide. T2DM is associated with both microvascular (neuropathy, nephropathy and retinopathy) and macrovascular complications [coronary artery disease (CAD), stroke, carotid artery disease and peripheral artery disease (PAD)].
   Apart from acting on diabetic dyslipidemia, statins were shown to exert beneficial effects on several diabetic complications as well as other cardiovascular (CVD) risk predictors such as endothelial dysfunction, inflammation, oxidative stress, chronic kidney disease (CKD), non-alcoholic fatty liver disease (NAFLD), metabolic syndrome (MetS), obstructive sleep apnea syndrome (OSAS) and hyperuricemia.
   Several clinical trials involving T2DM patients have reported significant reductions in coronary and cerebrovascular events following statin treatment. However, a modest statin-related risk of new-onset diabetes (NOD) has been reported but that did outweigh the benefit of CVD risk reduction in high-risk individuals.
   Overall, statin use is beneficial and should be recommended in diabetic patients to target their increased CVD risk.
C1 [Katsiki, Niki; Athyros, Vasilios G.; Karagiannis, Asterios] Aristotle Univ Thessaloniki, Sch Med, Hippocrat Hosp, Propedeut Dept Internal Med 2, GR-54006 Thessaloniki, Greece.
   [Mikhailidis, Dimitri P.] UCL, Univ Coll London Med Sch, Dept Clin Biochem, Vasc Dis Prevent Clinic, London NW3 2QG, England.
   [Mikhailidis, Dimitri P.] UCL, Univ Coll London Med Sch, Dept Surg, London NW3 2QG, England.
C3 Aristotle University of Thessaloniki; University of London; University
   College London; University of London; University College London
RP Mikhailidis, DP (corresponding author), UCL, Univ Coll Med Sch, Royal Free Hosp Campus, Dept Clin Biochem, Pond St, London NW3 2QG, England.
EM MIKHAILIDIS@aol.com
RI Mikhailidis, Dimitri/A-1869-2013; Athyros, V.G./H-5328-2019; KATSIKI,
   NIKI/ADE-7999-2022
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NR 163
TC 46
Z9 47
U1 0
U2 27
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1381-6128
EI 1873-4286
J9 CURR PHARM DESIGN
JI Curr. Pharm. Design
PY 2014
VL 20
IS 22
BP 3665
EP 3674
DI 10.2174/13816128113196660673
PG 10
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA AK5CE
UT WOS:000338441000017
PM 24040875
DA 2025-06-11
ER

PT J
AU Royes, LFF
   Gomez-Pinilla, F
AF Freire Royes, Luiz Fernando
   Gomez-Pinilla, Fernando
TI Making sense of gut feelings in the traumatic brain injury pathogenesis
SO NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
LA English
DT Review
DE Metabolic syndrome; TBI; Inflammation; Autonomic nervous system; Brain
   plasticity
ID GROWTH-HORMONE DEFICIENCY; BODY-MASS INDEX; MITOCHONDRIAL TRANSCRIPTION
   FACTOR; NF-KAPPA-B; INSULIN-RESISTANCE; OXIDATIVE STRESS;
   SKELETAL-MUSCLE; METABOLIC SYNDROME; PHYSICAL-EXERCISE; FACTOR-I
AB Traumatic brain injury (TBI) is a devastating condition which often initiates a sequel of neurological disorders that can last throughout lifespan. From metabolic perspective, TBI also compromises systemic physiology including the function of body organs with subsequent malfunctions in metabolism. The emerging panorama is that the effects of TBI on the periphery strike back on the brain and exacerbate the overall TBI pathogenesis. An increasing number of clinical reports are alarming to show that metabolic dysfunction is associated with incidence of long-term neurological and psychiatric disorders. The autonomic nervous system, associated hypothalamic-pituitary axis, and the immune system are at the center of the interface between brain and body and are central to the regulation of overall homeostasis and disease. We review the strong association between mechanisms that regulate cell metabolism and inflammation which has important clinical implications for the communication between body and brain. We also discuss the integrative actions of lifestyle interventions such as diet and exercise on promoting brain and body health and cognition after TBI.
C1 [Freire Royes, Luiz Fernando] Fed Univ Santa Maria UFSM, Ctr Phys Educ & Sports, Exercise Biochem Lab, Santa Maria, RS, Brazil.
   [Gomez-Pinilla, Fernando] Univ Calif Los Angeles, UCLA Brain Injury Res Ctr, Dept Neurosurg, Los Angeles, CA USA.
   [Gomez-Pinilla, Fernando] Univ Calif Los Angeles, UCLA Brain Injury Res Ctr, Dept Integrat & Biol & Physiol, Los Angeles, CA USA.
C3 Universidade Federal de Santa Maria (UFSM); University of California
   System; University of California Los Angeles; University of California
   System; University of California Los Angeles
RP Gomez-Pinilla, F (corresponding author), Univ Calif Los Angeles, Dept Integrat Biol & Physiol, Los Angeles, CA 90095 USA.
EM fgomezpi@ucla.edu
RI royes, luiz/T-3581-2019
FU National Institute of Health [R01 NS50465]; Conselho Nacional de
   Desenvolvimento Cientifico e Tecnologico award CNPq [307382/2017-6]
FX This work was supported by The National Institute of Health award R01
   NS50465 to FGP, and Conselho Nacional de Desenvolvimento Cientifico e
   Tecnologico award CNPq: #307382/2017-6 to LFR. Author would like to
   thanks Rafael Parcianelio Cipolat for reviewing the colorartwork
   (Figures).
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NR 250
TC 31
Z9 34
U1 0
U2 9
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0149-7634
EI 1873-7528
J9 NEUROSCI BIOBEHAV R
JI Neurosci. Biobehav. Rev.
PD JUL
PY 2019
VL 102
BP 345
EP 361
DI 10.1016/j.neubiorev.2019.05.012
PG 17
WC Behavioral Sciences; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Behavioral Sciences; Neurosciences & Neurology
GA IE1EF
UT WOS:000472128000025
PM 31102601
OA Green Submitted, Green Accepted
DA 2025-06-11
ER

PT J
AU Vogt, B
   Burnier, M
AF Vogt, Bruno
   Burnier, Michel
TI Aldosterone and cardiovascular risk
SO CURRENT HYPERTENSION REPORTS
LA English
DT Article
ID PLASMA-RENIN ACTIVITY; BLOOD-PRESSURE; METABOLIC SYNDROME; SERUM
   ALDOSTERONE; PRIMARY HYPERALDOSTERONISM; INSULIN; HYPERTENSION;
   INHIBITION; FIBROSIS; SALT
AB Through its classic effects on sodium and potassium homeostasis, aldosterone, when produced in excess, is associated with the development of hypertension and hence with higher cardiovascular and renal risk. In recent years, experimental and epidemiologic data have suggested that aldosterone also may be linked to high cardiovascular risk independently of its effects on blood pressure. Thus, aldosterone has been associated with obesity and metabolic syndrome in selected populations, and these associations may further contribute to the higher cardiovascular risk of subjects with elevated aldosterone levels. Moreover, aldosterone has been reported to promote inflammation, oxidative stress, and fibrosis in a number of tissues. Clinical evidence indicates that patients with primary hyperaldosteronism have a higher risk of developing cardiovascular and renal complications than patients with essential hypertension who have the same level of blood pressure. Aldosterone receptor blockade has been shown to lower cardiovascular mortality after myocardial infarction and in patients with congestive heart failure. Some studies have also demonstrated that aldosterone blockade could have a favorable impact on the progression of renal disease. However, prospective interventional trials are needed to further evaluate the impact of blockade of aldosterone on cardiovascular risk.
C1 [Burnier, Michel] CHU Vaudois, Serv Nephrol & Hypertens, CH-1011 Lausanne, Switzerland.
C3 University of Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV)
RP Burnier, M (corresponding author), CHU Vaudois, Serv Nephrol & Hypertens, Rue Bugnon 17, CH-1011 Lausanne, Switzerland.
EM michel.burnier@chuv.ch
RI Burnier, Michel/HWQ-3033-2023; Vogt, Bruno/AAS-2876-2020
OI Vogt, Bruno/0000-0002-1548-6387
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NR 50
TC 19
Z9 22
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1522-6417
EI 1534-3111
J9 CURR HYPERTENS REP
JI Curr. Hypertens. Rep.
PD DEC
PY 2009
VL 11
IS 6
BP 450
EP 455
DI 10.1007/s11906-009-0076-8
PG 6
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 524YX
UT WOS:000272181400010
PM 19895757
DA 2025-06-11
ER

PT J
AU Jaja-Chimedza, A
   Zhang, L
   Wolff, K
   Graf, BL
   Kuhn, P
   Moskal, K
   Carmouche, R
   Newman, S
   Salbaum, JM
   Raskin, I
AF Jaja-Chimedza, Asha
   Zhang, Li
   Wolff, Khea
   Graf, Brittany L.
   Kuhn, Peter
   Moskal, Kristin
   Carmouche, Richard
   Newman, Susan
   Salbaum, J. Michael
   Raskin, Ilya
TI A dietary isothiocyanate-enriched moringa (Moringa oleifera) seed
   extract improves glucose tolerance in a high-fat-diet mouse model and
   modulates the gut microbiome
SO JOURNAL OF FUNCTIONAL FOODS
LA English
DT Article
DE Moringa; Moringa seed extract; Isothiocyanate; Metabolic syndrome; Gut
   microbiota; Blood glucose
ID INSULIN-RESISTANCE; METABOLIC SYNDROME; OXIDATIVE STRESS; MICE; OBESITY;
   INFLAMMATION; EXPRESSION; LIVER; HYPERGLYCEMIA; MACROPHAGES
AB Moringa oleifera (moringa) has been traditionally used for the treatment of diabetes and in water purification. We previously showed that moringa seed extract (MSE), standardized to its primary bioactive isothiocyanate (MIC-1), modulated inflammatory and antioxidant signaling pathways in vitro. To understand the efficacy and mechanisms of action of MSE in vivo, we incorporated MSE into the diets of normal and obese C57BL/6J male mice fed a standard low-fat diet or a very high-fat diet for 12 wk, respectively. MSE supplementation resulted in reduced body weight, decreased adiposity, improved glucose tolerance, reduced inflammatory gene expression, and increased antioxidant gene expression. 16S rRNA gene sequencing and quantitative PCR of fecal/cecal samples showed major modulation of the gut microbial community and a significantly reduced bacterial load, similar to an antibiotic response. This suggests that MSE improves metabolic health by its intracellular antiinflammatory and antioxidant activities, and/or its antibiotic-like restructuring of the gut microbiota.
C1 [Jaja-Chimedza, Asha; Zhang, Li; Wolff, Khea; Graf, Brittany L.; Kuhn, Peter; Moskal, Kristin; Raskin, Ilya] Rutgers State Univ, Sch Environm & Biol Sci, Dept Plant Biol, New Brunswick, NJ 08901 USA.
   [Carmouche, Richard; Newman, Susan; Salbaum, J. Michael] Louisiana State Univ, Pennington Biomed Res Ctr, Baton Rouge, LA 70808 USA.
   [Zhang, Li] Shandong Univ, Sch Stomatol, Dept Human Microbiome, Shandong Prov Key Lab Oral Tissue Regenerat, Jinan 250012, Shandong, Peoples R China.
C3 Rutgers University System; Rutgers University New Brunswick; Louisiana
   State University System; Louisiana State University; Pennington
   Biomedical Research Center; Shandong University
RP Jaja-Chimedza, A; Raskin, I (corresponding author), Rutgers State Univ, Sch Environm & Biol Sci, Dept Plant Biol, New Brunswick, NJ 08901 USA.
EM jaja@sebs.rutgers.edu; raskin@sebs.rutgers.edu
OI Moskal, Kristin/0000-0001-5814-5497
FU National Center For Complementary & Integrative Health; Department of
   Plant Biology in the School of Environmental and Biological Sciences
   (SEBS) of Rutgers University; Rutgers University; COBRE [NIH8
   1P30GM118430-01]; NORC [NIH 2P30DK072476];  [5T32AT004094]
FX This publication was supported by the National Center For Complementary
   & Integrative Health and the of the under Award Number and 5T32AT004094,
   which fund the Botanical Research Center of Pennington Biomedical
   Research Center and the Department of Plant Biology in the School of
   Environmental and Biological Sciences (SEBS) of Rutgers University, and
   by the at Rutgers University (AJC, BLG, PK and IR). The content is
   solely the responsibility of the authors and does not necessarily
   represent the official views of the. This project/work used genomics
   core facilities that are supported in part by COBRE (NIH8
   1P30GM118430-01) and NORC (NIH 2P30DK072476) center grants from the.
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NR 60
TC 59
Z9 63
U1 0
U2 56
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1756-4646
J9 J FUNCT FOODS
JI J. Funct. Food.
PD AUG
PY 2018
VL 47
BP 376
EP 385
DI 10.1016/j.jff.2018.05.056
PG 10
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA GN4RH
UT WOS:000439019200041
PM 30930963
OA Bronze, Green Accepted
DA 2025-06-11
ER

PT J
AU Chin, B
   Murphy, MLM
   Cohen, S
AF Chin, Brian
   Murphy, Michael L. M.
   Cohen, Sheldon
TI Age moderates the association between social integration and diurnal
   cortisol measures
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE Salivary cortisol; Social integration; Age; Diurnal slopes
ID SALIVARY CORTISOL; METABOLIC SYNDROME; HEART-DISEASE; HEALTH; MORTALITY;
   SUSCEPTIBILITY; SUPPORT; SLOPES; ADULTS; RELIABILITY
AB Social integration is defined as the degree to which an individual participates in a broad range of social relationships. Although measures of social integration vary across studies, it is often assessed as the number of social roles (e.g., parent, friend, student, volunteer) that an individual reports actively participating in. More socially integrated individuals tend to be healthier than those less socially integrated, but the biological mechanisms through which this occurs remain unclear. One possibility is that social integration might alter the function of the hypothalamic-pituitary-adrenal axis, of which cortisol is a key product, and in turn influence a broad range of health outcomes. This study examined the association between social integration and two indices of cortisol in a community sample of 680 healthy men and women aged 18-55. Because the social roles held by younger individuals may be more numerous yet superficial than those held by older individuals, this study also tested the hypothesis that these associations could be moderated by age such that lower levels of integration would be associated with cortisol dysregulation for older but not younger individuals in our sample. Participants provided salivary cortisol samples during waking hours on three days that were used to calculate diurnal cortisol levels and slopes. Increased social integration was associated with lower cortisol AUC among older (ages 35-55) but not younger (ages 18-34) individuals in our sample. Moreover, while increased social integration was associated with steeper diurnal cortisol slopes regardless of age, this association was strongest among older individuals. Differences in health behaviors, affect, and psychological stress did not mediate these associations. The results of this study support cortisol as a candidate biological mechanism through which increased social integration is associated with better physical health among older individuals.
C1 [Chin, Brian; Murphy, Michael L. M.; Cohen, Sheldon] Carnegie Mellon Univ, Dept Psychol, 5000 Forbes Ave, Pittsburgh, PA 15213 USA.
C3 Carnegie Mellon University
RP Cohen, S (corresponding author), Carnegie Mellon Univ, Dept Psychol, 5000 Forbes Ave, Pittsburgh, PA 15213 USA.
EM scohen@cmu.edu
RI Chin, Brian/GPS-4971-2022
OI Chin, Brian/0000-0003-4643-0172; Murphy, Michael/0000-0001-7776-3186
FU National Center for Complementary and Integrative Health [AT006694];
   National Institute of Mental Health [MH50429]; National Heart, Lung, and
   Blood Institute [HL65111, HL65112HL65111]; National Institute for
   Allergy and Infectious Diseases [R01 AI066367]; National Institutes of
   Health [NCRR/GCRC 5M01 RR00056, UL1 RR024153, UL1 RT000005]; John D. and
   Catherine T. MacArthur Foundation Research Network on Socioeconomic
   Status Health
FX Preparation of this paper was supported by a grant from the National
   Center for Complementary and Integrative Health (AT006694); the conduct
   of the studies was supported by grants from the National Institute of
   Mental Health (MH50429), National Heart, Lung, and Blood Institute
   (HL65111; HL65112HL65111), and National Institute for Allergy and
   Infectious Diseases (R01 AI066367); and secondary support was provided
   by a grant from the National Institutes of Health to the University of
   Pittsburgh Medical Center General Clinical Research Center (NCRR/GCRC
   5M01 RR00056) and from the National Institutes of Health to the
   University of Pittsburgh Clinical and Translational Science Institute
   (UL1 RR024153 and UL1 RT000005); and supplemental support was provided
   by John D. and Catherine T. MacArthur Foundation Research Network on
   Socioeconomic Status & Health. We thank David Creswell and Brooke Feeney
   for their feedback on an earlier version of this manuscript.
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NR 52
TC 12
Z9 13
U1 0
U2 7
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
EI 1873-3360
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD APR
PY 2018
VL 90
BP 102
EP 109
DI 10.1016/j.psyneuen.2018.02.008
PG 8
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA GD8LV
UT WOS:000430764800013
PM 29477953
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Spann, SJ
   Gillespie, CF
   Davis, JS
   Brown, A
   Schwartz, A
   Wingo, A
   Habib, L
   Ressler, KJ
AF Spann, Sarah J.
   Gillespie, Charles F.
   Davis, Jennifer S.
   Brown, Angelo
   Schwartz, Ann
   Wingo, Aliza
   Habib, Leah
   Ressler, Kerry J.
TI The association between childhood trauma and lipid levels in an adult
   low-income, minority population
SO GENERAL HOSPITAL PSYCHIATRY
LA English
DT Article
DE Trauma; African-American; Genetic; Cardiovascular; Lipids
ID POSTTRAUMATIC-STRESS-DISORDER; ADMINISTERED PTSD SCALE; METABOLIC
   SYNDROME; SUBSTANCE-ABUSE; HPA AXIS; HEALTH; DEPRESSION; VETERANS;
   EXPOSURE; DISPARITIES
AB Background: The objective of this study is to investigate the association between childhood trauma and lipid profiles in adults from a highly traumatized population at-risk for cardiovascular disease.
   Method: We recruited 452 participants, primarily African-American and of low socioeconomic status, from general medical clinics in a large urban hospital. We performed direct comparisons, univariate analysis of variance and regression analyses together and separated by sex, examining the associations of child abuse, body mass index, lipid lowering drug use, blood pressure, age, and substance use to HDL levels and HDL/LDL ratios.
   Results: A history of moderate to severe levels of childhood trauma and abuse was associated with a significant decrease in HDL levels (P <=.01) and HDL/LDL ratios (P <=.001) relative to males with low levels of abuse. This relationship held when the status of lipid-lowering drugs was considered. When controlling for age, substance abuse, tobacco use, and adult trauma, the effects of childhood trauma remained significant. We found a significant child abuse by sex interaction on HDL/LDL ratios [F(1,369)=13.0, P <=.0005] consistent with a differential effect of trauma on dyslipidemia in male but not female subjects.
   Conclusions: Our data suggest that childhood trauma exposure, obtained with self-report measures, may contribute to increased risk of cardiovascular disease by way of stress-mediated alterations of lipid concentration and composition in male, but not female, subjects. (C) 2014 Elsevier Inc. All rights reserved.
C1 [Spann, Sarah J.; Gillespie, Charles F.; Davis, Jennifer S.; Brown, Angelo; Schwartz, Ann; Wingo, Aliza; Habib, Leah; Ressler, Kerry J.] Emory Univ, Sch Med, Dept Psychiat & Behav Sci, Atlanta, GA 30329 USA.
   [Wingo, Aliza] Atlanta VA Med Ctr, Atlanta, GA USA.
   [Ressler, Kerry J.] Howard Hughes Med Inst, Chevy Chase, MD USA.
   [Ressler, Kerry J.] Yerkes Natl Primate Res Ctr, Atlanta, GA USA.
C3 Emory University; US Department of Veterans Affairs; Veterans Health
   Administration (VHA); Atlanta VA Health Care System; Atlanta VA Medical
   Center; Howard Hughes Medical Institute
RP Ressler, KJ (corresponding author), Emory Univ, Howard Hughes Med Inst, Dept Psychiat & Behav Sci, Yerkes Res Ctr, 954 Gatewood Dr, Atlanta, GA 30329 USA.
EM kressle@emory.edu
RI Gillespie, Charles/G-8481-2012; Schwartz, Ann/JOZ-9672-2023; Ressler,
   Kerry/N-8741-2018
OI Ressler, Kerry/0000-0002-5158-1103; Gillespie,
   Charles/0000-0001-5476-5920
FU APIRE/Wyeth; NARSAD; NIDA; NIMH; Burroughs Wellcome Foundation
FX There were no commercial sponsors or commercial relationships related to
   the current work. All additional financial ties of the investigators
   within the last 3 years are disclosed herein: Dr. Gillespie has received
   funding from APIRE/Wyeth, NARSAD, NIDA, and NIMH. Dr. Ressler has
   received awards and/or funding support related to other studies from
   Burroughs Wellcome Foundation, NARSAD, NIMH and NIDA and is a cofounder
   of Extinction Pharmaceuticals for use of NMDA-based therapeutics with
   Psychotherapy.
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NR 51
TC 22
Z9 25
U1 1
U2 15
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0163-8343
EI 1873-7714
J9 GEN HOSP PSYCHIAT
JI Gen. Hosp. Psych.
PD MAR-APR
PY 2014
VL 36
IS 2
BP 150
EP 155
DI 10.1016/j.genhosppsych.2013.10.004
PG 6
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA AC4XZ
UT WOS:000332525900004
PM 24315076
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Allen, MS
AF Allen, Mark S.
TI Physical activity as an adjunct treatment for erectile dysfunction
SO NATURE REVIEWS UROLOGY
LA English
DT Review
ID IMPROVES ENDOTHELIAL FUNCTION; NITRIC-OXIDE; SEXUAL DYSFUNCTION;
   BODY-IMAGE; METABOLIC SYNDROME; PSYCHOLOGICAL INTERVENTIONS;
   CARDIOVASCULAR-DISEASE; DEPRESSIVE SYMPTOMS; INTERNATIONAL INDEX;
   EXERCISE INTENSITY
AB Increasing data are available to suggest that physical activity and lifestyle modification in general can benefit erectile function, with effect sizes comparable with established treatment options such as testosterone therapy and phosphodiesterase type 5 inhibitors. Despite this evidence, primary-care physicians are rarely afforded critical information on the underlying mechanisms through which physical activity works as a treatment, severely hampering treatment credibility for both physician and patient. Physical activity is associated with psychological and metabolic adaptations that are compatible with the adaptations required for the treatment of erectile dysfunction (ED). These adaptations include increased expression and activity of nitric oxide synthase, strengthened endothelial function, acute rises in testosterone, decreased stress and anxiety, and improved body image. Use of physical activity as a first-line treatment option for ED is limited, and explicit physical activity guidelines for the treatment of ED are required. Such guidelines should include not only a suggested exercise programme but also guidelines for physician-patient communication that might enhance patient receptivity and therapy continuation. An understanding of how physical activity affects erectile function, as well as its effectiveness in treating ED compared with other established treatments, can benefit urologists and primary-care physicians searching for noninvasive treatment options for men presenting with poor erectile function.
C1 [Allen, Mark S.] Univ Wollongong, Fac Social Sci, Wollongong, NSW, Australia.
C3 University of Wollongong
RP Allen, MS (corresponding author), Univ Wollongong, Fac Social Sci, Wollongong, NSW, Australia.
EM mark_allen@uow.edu.au
OI Allen, Mark/0000-0001-5511-9680
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NR 147
TC 26
Z9 30
U1 0
U2 19
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 1759-4812
EI 1759-4820
J9 NAT REV UROL
JI Nat. Rev. Urol.
PD SEP
PY 2019
VL 16
IS 9
BP 553
EP 562
DI 10.1038/s41585-019-0210-6
PG 10
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Urology & Nephrology
GA IV6JR
UT WOS:000484375200008
PM 31239541
DA 2025-06-11
ER

PT J
AU Memaj, P
   Jornayvaz, FR
AF Memaj, Plator
   Jornayvaz, Francois R.
TI Non-alcoholic fatty liver disease in type 1 diabetes: Prevalence and
   pathophysiology
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Review
DE NAFLD; type 1 diabetes; glycogenic hepatopathy; prevalence;
   pathophysiology
ID GLYCOGENIC HEPATOPATHY; INSULIN-RESISTANCE; COMPLICATION; PRAMLINTIDE;
   CLEARANCE; SECRETION; CIRRHOSIS; WEIGHT
AB Non-alcoholic fatty liver disease (NAFLD) is the most frequent chronic liver disease in the general population with a global prevalence of 25%. It is often associated with metabolic syndrome and type 2 diabetes, as insulin resistance and hyperinsulinemia are known to be favoring factors. Recent studies have described growing incidence of NAFLD in type 1 diabetes (T1D) as well. Although increasing prevalence of metabolic syndrome in these patients seems to explain part of this increase in NAFLD, other underlying mechanisms may participate in the emergence of NAFLD. Notably, some genetic factors are more associated with fatty liver disease, but their prevalence in T1D has not been evaluated. Moreover, oxidative stress, poor glucose control and long-lasting hyperglycemia, as well as exogenous insulin administration play an important role in intrahepatic fat homeostasis. The main differential diagnosis of NAFLD in T1D is glycogenic hepatopathy, which needs to be considered mostly in T1D patients with poor glycemic control. This article aims to review the prevalence and pathophysiology of NAFLD in T1D and open perspectives for clinicians taking care of T1D patients with potential hepatopathy.
C1 [Memaj, Plator; Jornayvaz, Francois R.] Geneva Univ Hosp, Dept Med, Div Endocrinol, Diabet, Geneva, Switzerland.
   [Jornayvaz, Francois R.] Univ Geneva, Fac Med, Diabet Ctr, Geneva, Switzerland.
   [Jornayvaz, Francois R.] Univ Geneva, Fac Med, Dept Cell Physiol & Metab, Geneva, Switzerland.
C3 University of Geneva; University of Geneva; University of Geneva
RP Jornayvaz, FR (corresponding author), Geneva Univ Hosp, Dept Med, Div Endocrinol, Diabet, Geneva, Switzerland.; Jornayvaz, FR (corresponding author), Univ Geneva, Fac Med, Diabet Ctr, Geneva, Switzerland.; Jornayvaz, FR (corresponding author), Univ Geneva, Fac Med, Dept Cell Physiol & Metab, Geneva, Switzerland.
EM francois.jornayvaz@hcuge.ch
RI Jornayvaz, François/AAL-2134-2020
OI Jornayvaz, Francois/0000-0001-9425-3137
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NR 65
TC 17
Z9 18
U1 0
U2 8
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD DEC 1
PY 2022
VL 13
AR 1031633
DI 10.3389/fendo.2022.1031633
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 7A3XB
UT WOS:000898392300001
PM 36531463
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Li, YH
   Zheng, NN
   Ding, XD
AF Li, Yunhao
   Zheng, Ningning
   Ding, Xudong
TI Mitophagy Disequilibrium, a Prominent Pathological Mechanism in
   Metabolic Heart Diseases
SO DIABETES METABOLIC SYNDROME AND OBESITY
LA English
DT Review
DE mitophagy; metabolic heart diseases; metabolic syndrome; PTEN induced
   putative kinase; PINK; parkin; Bcl-2; BNIP3; FUN14 domain-containing
   protein 1; FUNDC1; ferroptosis
ID CATHEPSIN-D; CELL-DEATH; MITOCHONDRIAL DYSFUNCTION; CARDIAC DYSFUNCTION;
   MEDIATED MITOPHAGY; OXIDATIVE STRESS; E3 LIGASE; AUTOPHAGY; PROTEIN;
   MTOR
AB With overall food intake among the general population as high as ever, metabolic syndrome (MetS) has become a global epidemic and is responsible for many serious life threatening diseases, especially heart failure. In multiple metabolic disorders, maintaining a dynamic balance of mitochondrial number and function is necessary to prevent the overproduction of reactive oxygen species (ROS), which has been proved to be one of the important mechanisms of cardiomyocyte injury due to the mismatching of oxygen consumption and mitochondrial population and finally to heart failure. Mitophagy is a process that eliminates damaged or redundant mitochondria. It is mediated by a series of signaling molecules, including PINK, parkin, BINP3, FUNDC1, CTSD, Drp1, Rab9 and mTOR. Meanwhile, increasing evidence also showed that the interaction between ferroptosis and mitophagy interfered with mitochondrial homeostasis. This review will focus on these essential molecules and pathways of mitophagy and cell homeostasis affected by hypoxia and other stimuli in metabolic heart diseases.
C1 [Li, Yunhao] China Med Univ, Clin Coll 1, Shenyang, Liaoning, Peoples R China.
   [Zheng, Ningning] China Med Univ, Coll Basic Med Sci, Dept Pathophysiol, Shenyang, Liaoning, Peoples R China.
   [Ding, Xudong] China Med Univ, Dept Anesthesiol, Shengjing Hosp, 36 Sanhao St, Shenyang 110004, Liaoning, Peoples R China.
C3 China Medical University; China Medical University; China Medical
   University
RP Ding, XD (corresponding author), China Med Univ, Dept Anesthesiol, Shengjing Hosp, 36 Sanhao St, Shenyang 110004, Liaoning, Peoples R China.
EM dingxd@sj-hospital.org
RI Zheng, Ningning/KHU-0389-2024; Li, Yunhao/HCI-0205-2022
OI Li, Yunhao/0000-0002-5359-2930
FU National Natural Science Foundation of China [81800763]; Natural Science
   Foundation of Liaoning Province of China [20180551076, 2013021046]
FX The work was supported by the National Natural Science Foundation of
   China (FUND#81800763), the Natural Science Foundation of Liaoning
   Province of China (FUND#20180551076) and the Natural Science Foundation
   of Liaoning Province of China (FUND#2013021046).
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NR 110
TC 11
Z9 11
U1 6
U2 28
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-7007
J9 DIABET METAB SYND OB
JI Diabetes Metab. Syndr. Obes.
PY 2021
VL 14
BP 4631
EP 4640
DI 10.2147/DMSO.S336882
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA XE2SE
UT WOS:000723243000003
PM 34858041
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Burgess, A
   Vanella, L
   Bellner, L
   Schwartzman, ML
   Abraham, NG
AF Burgess, Angela
   Vanella, Luca
   Bellner, Lars
   Schwartzman, Michal L.
   Abraham, Nader G.
TI Epoxyeicosatrienoic acids and heme oxygenase-1 interaction attenuates
   diabetes and metabolic syndrome complications
SO PROSTAGLANDINS & OTHER LIPID MEDIATORS
LA English
DT Review
DE MSC; EET-agonist; HO-1; pAKT; Adipocyte
ID ACTIVATED PROTEIN-KINASE; IMPROVES INSULIN SENSITIVITY;
   ISCHEMIA-REPERFUSION INJURY; INCREASES ADIPONECTIN LEVELS; VISCERAL
   ADIPOSE-TISSUE; MESENCHYMAL STEM-CELLS; OXIDATIVE STRESS;
   ARACHIDONIC-ACID; CARBON-MONOXIDE; AUTOIMMUNE-DISEASES
AB MSCs are considered to be the natural precursors to adipocyte development through the process of adipogenesis. A link has been established between decreased protective effects of EETs or HO-1 and their interaction in metabolic syndrome. Decreases in HO-1 or EET were associated with an increase in adipocyte stem cell differentiation and increased levels of inflammatory cytokines. EET agonist (AKR-I-27-28) inhibited MSC-derived adipocytes and decreased the levels of inflammatory cytokines. We further describe the role of CYP-epoxygenase expression, HO expression, and circulating cytokine levels in an obese mouse, ob/ob(-/-) mouse model. Ex vivo measurements of EET expression within MSCs derived from ob/ob(-/-) showed decreased levels of EETs that were increased by HO induction. This review demonstrates that suppression of HO and EET systems exist in MSCs prior to the development of adipocyte dysfunction. Further, adipocyte dysfunction can be ameliorated by induction of HO-1 and CYP-epoxygenase, i.e. EET. (C) 2011 Elsevier Inc. All rights reserved.
C1 [Burgess, Angela; Vanella, Luca; Abraham, Nader G.] Univ Toledo, Dept Physiol & Pharmacol, Coll Med, Toledo, OH 43614 USA.
   [Bellner, Lars; Schwartzman, Michal L.] New York Med Coll, Dept Pharmacol, Valhalla, NY 10595 USA.
C3 University System of Ohio; University of Toledo; New York Medical
   College
RP Abraham, NG (corresponding author), Univ Toledo, Dept Physiol & Pharmacol, Coll Med, Toledo, OH 43614 USA.
EM Nader.Abraham@utoledo.edu
RI Vanella, Luca/J-7354-2016
OI Vanella, Luca/0000-0002-6314-6029
FU NHLBI NIH HHS [P01 HL034300] Funding Source: Medline; NIDDK NIH HHS [R01
   DK056601, R01 DK068134] Funding Source: Medline
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NR 156
TC 33
Z9 35
U1 0
U2 5
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1098-8823
EI 2212-196X
J9 PROSTAG OTH LIPID M
JI Prostaglandins Other Lipid Mediat.
PD JAN
PY 2012
VL 97
IS 1-2
BP 1
EP 16
DI 10.1016/j.prostaglandins.2011.10.002
PG 16
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA 897MI
UT WOS:000300654400001
PM 22100745
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Islam, MR
   Rauf, A
   Akash, S
   Trisha, SI
   Nasim, AH
   Akter, M
   Dhar, PS
   Ogaly, HA
   Hemeg, HA
   Wilairatana, P
   Thiruvengadam, M
AF Islam, Md. Rezaul
   Rauf, Abdur
   Akash, Shopnil
   Trisha, Sadiya Islam
   Nasim, Akram Hossain
   Akter, Muniya
   Dhar, Puja Sutro
   Ogaly, Hanan A.
   Hemeg, Hassan A.
   Wilairatana, Polrat
   Thiruvengadam, Muthu
TI Targeted therapies of curcumin focus on its therapeutic benefits in
   cancers and human health: Molecular signaling pathway-based approaches
   and future perspectives
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Review
DE Curcuma longa; Curcumin; Turmeric; Antioxidant; Anti-inflammatory;
   Medicine; Cancer
ID NF-KAPPA-B; HUMAN BREAST-CANCER; CELL-CYCLE ARREST; CHEMOPREVENTIVE
   AGENT CURCUMIN; IN-VITRO; OXIDATIVE STRESS; GENE-EXPRESSION;
   COLON-CANCER; INDUCED APOPTOSIS; IMMUNE-SYSTEM
AB The curry powder spices turmeric (Curcuma longa L.), which contains curcumin (diferuloylmethane), an orangeyellow chemical. Polyphenols are the most commonly used sources of curcumin. It combats oxidative stress and inflammation in diseases, such as hyperlipidemia, metabolic syndrome, arthritis, and depression. Most of these benefits are due to their anti-inflammatory and antioxidant properties. Curcumin consumption leads to decreased bioavailability, resulting in limited absorption, quick metabolism, and quick excretion, which hinders health improvement. Numerous factors can increase its bioavailability. Piperine enhances bioavailability when combined with curcumin in a complex. When combined with other enhancing agents, curcumin has a wide spectrum of health benefits. This review evaluates the therapeutic potential of curcumin with a specific emphasis on its approach based on molecular signaling pathways. This study investigated its influence on the progression of cancer, inflammation, and many health-related mechanisms, such as cell proliferation, apoptosis, and metastasis. Curcumin has a significant potential for the prevention and treatment of various diseases. Curcumin modulates several biochemical pathways and targets involved in cancer growth. Despite its limited tissue accumulation and bioavailability when administered orally, curcumin has proven useful. This review provides an in-depth analysis of curcumin's therapeutic applications, its molecular signaling pathway-based approach, and its potential for precision medicine in cancer and human health.
C1 [Islam, Md. Rezaul; Akash, Shopnil; Trisha, Sadiya Islam; Nasim, Akram Hossain; Akter, Muniya; Dhar, Puja Sutro] Daffodil Int Univ, Fac Allied Hlth Sci, Dept Pharm, Dhaka 1216, Bangladesh.
   [Rauf, Abdur] Univ Swabi, Dept Chem, Anbar 23561, Khyber Pakhtunk, Pakistan.
   [Ogaly, Hanan A.] King Khalid Univ, Coll Sci, Chem Dept, Abha 61421, Saudi Arabia.
   [Hemeg, Hassan A.] Taibah Univ, Coll Appl Med Sci, Dept Med Lab Technol, Al Medinah Al Monawara, Saudi Arabia.
   [Wilairatana, Polrat] Mahidol Univ, Fac Trop Med, Dept Clin Trop Med, Bangkok 10400, Thailand.
   [Thiruvengadam, Muthu] Konkuk Univ, Coll Life & Environm Sci, Dept Appl Biosci, Seoul 05029, South Korea.
   [Thiruvengadam, Muthu] Saveetha Univ, Saveetha Inst Med & Tech Sci SIMATS, Saveetha Dent Coll & Hosp, Dept Microbiol, Chennai 600077, India.
C3 Daffodil International University; King Khalid University; Taibah
   University; Mahidol University; Konkuk University; Saveetha Institute of
   Medical & Technical Science; Saveetha Dental College & Hospital
RP Rauf, A (corresponding author), Univ Swabi, Dept Chem, Anbar 23561, Khyber Pakhtunk, Pakistan.; Wilairatana, P (corresponding author), Mahidol Univ, Fac Trop Med, Dept Clin Trop Med, Bangkok 10400, Thailand.; Thiruvengadam, M (corresponding author), Konkuk Univ, Coll Life & Environm Sci, Dept Appl Biosci, Seoul 05029, South Korea.
EM mashaljcs@yahoo.com; polrat.wil@mahidol.ac.th; muthu@konkuk.ac.kr
RI Ogaly, Hanan/ACA-5011-2022; Islam, Md. Rezaul/ABC-5725-2021;
   Thiruvengadam, Muthu/AAP-8023-2021; Rauf, Abdur/G-3304-2013
FU Deanship of Scientific Research at King Khalid University [RGP2/93/44]
FX Deanship of Scientific Research at King Khalid University for funding
   this work through large group Research Project under grant number
   RGP2/93/44.
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NR 319
TC 44
Z9 44
U1 7
U2 23
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD JAN
PY 2024
VL 170
AR 116034
DI 10.1016/j.biopha.2023.116034
EA DEC 2023
PG 20
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA FD8W9
UT WOS:001143925000001
PM 38141282
OA gold
DA 2025-06-11
ER

PT J
AU Ghavipour, M
   Saedisomeolia, A
   Djalali, M
   Sotoudeh, G
   Eshraghyan, MR
   Moghadam, AM
   Wood, LG
AF Ghavipour, Mahsa
   Saedisomeolia, Ahmad
   Djalali, Mahmoud
   Sotoudeh, Giti
   Eshraghyan, Mohammad Reza
   Moghadam, Ali Malekshahi
   Wood, Lisa G.
TI Tomato juice consumption reduces systemic inflammation in overweight and
   obese females
SO BRITISH JOURNAL OF NUTRITION
LA English
DT Article
DE Tomato juice; Carotenoids; Lycopene; Inflammatory biomarkers; Obesity
ID FACTOR-KAPPA-B; METABOLIC SYNDROME-X; OXIDATIVE STRESS; PROINFLAMMATORY
   CYTOKINE; HEART-DISEASE; LYCOPENE; EXPRESSION; PROTEIN; MACROPHAGES;
   INHIBITION
AB Tomatoes are the richest source of lycopene, a potent antioxidant. Tomato products improve antioxidant defences and reduce the risk of inflammatory diseases, at least partly, due to the presence of lycopene. Lycopene, as an anti-inflammatory agent, prevents the production of inflammatory cytokines. Obesity is a chronic inflammatory condition in which the increased level of body fat leads to an increase in circulating inflammatory mediators. We hypothesised that the consumption of a lycopene-rich food would reduce inflammation in people who are overweight or obese. A total of 106 overweight or obese female students of the Tehran University of Medical Sciences were enrolled and randomly allocated to an intervention group (n 53) or a control group (n 53) consuming 330 ml/d of tomato juice or water, respectively, for 20 d. At baseline and day 20, serum concentrations of IL-6, IL-8, high-sensitivity C-reactive protein and TNF-alpha were analysed by ELISA and compared between the groups. Serum concentrations of IL-8 and TNF-alpha decreased significantly in the intervention group compared with the control group and with baseline. Subgroup analysis indicated that this effect was confined to subjects who were overweight. Among obese subjects, serum IL-6 concentration was decreased in the intervention group compared with the control group, with no differences in IL-8 and TNF-alpha observed. Tomato juice reduces inflammation in overweight and obese females. Thus, increasing tomato intake may provide a useful approach for reducing the risk of inflammatory diseases such as CVD and diabetes, which are associated with obesity.
C1 [Ghavipour, Mahsa; Saedisomeolia, Ahmad; Djalali, Mahmoud; Sotoudeh, Giti] Univ Tehran Med Sci, Sch Publ Hlth, Dept Biochem & Nutr, Tehran, Iran.
   [Eshraghyan, Mohammad Reza] Univ Tehran Med Sci, Sch Publ Hlth, Dept Epidemiol & Stat, Tehran, Iran.
   [Moghadam, Ali Malekshahi] Univ Tehran, Fac Vet Med, Tehran, Iran.
   [Wood, Lisa G.] Univ Newcastle, Sch Biomed Sci & Pharm, Callaghan, NSW 2308, Australia.
C3 Tehran University of Medical Sciences; Tehran University of Medical
   Sciences; University of Tehran; University of Newcastle
RP Saedisomeolia, A (corresponding author), Univ Tehran Med Sci, Sch Publ Hlth, Dept Biochem & Nutr, Tehran, Iran.
EM a_saedi@tums.ac.ir
RI Wood, Lisa/G-7068-2013; Sotoudeh, Gity/E-3973-2018
OI Wood, Lisa/0000-0002-0941-9225; Sotoudeh, Gity/0000-0001-6541-2581
FU Vice-chancellor for Research of Tehran University of Medical Sciences
   [10492]
FX The authors gratefully acknowledge the students and officials of Kooy
   and Vesal dormitories for their sincere cooperation. The present work
   was supported by the Vice-chancellor for Research of Tehran University
   of Medical Sciences (grant no. 10492), and the authors declare no
   conflict of interests. The authors would like to advise that all authors
   listed have contributed to the work. M. G. recruited the patients and
   collected the samples, performed laboratory tests, analysed the data and
   drafted the manuscript. A. S., G. S. and L. G. W. supervised the
   nutrition science experiments, contributed to the study design and
   reviewed the manuscript. M. D. supervised the biochemical experiments
   and contributed to the writing of the manuscript. M. R. E. contributed
   to the data analysis and the interpretation of results. A. M. M.
   performed laboratory tests and contributed to the writing of the
   manuscript.
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NR 28
TC 95
Z9 100
U1 0
U2 30
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1145
EI 1475-2662
J9 BRIT J NUTR
JI Br. J. Nutr.
PD JUN 14
PY 2013
VL 109
IS 11
BP 2031
EP 2035
DI 10.1017/S0007114512004278
PG 5
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 146WT
UT WOS:000319126700013
PM 23069270
OA Bronze
DA 2025-06-11
ER

PT J
AU Stubbs, B
AF Stubbs, B.
TI Antipsychotic-induced hyperprolactinaemia in patients with
   schizophrenia: considerations in relation to bone mineral density
SO JOURNAL OF PSYCHIATRIC AND MENTAL HEALTH NURSING
LA English
DT Article
DE antipsychotic medication; hyperprolactinaemia; osteoporosis; physical
   health & considerations into nursing practice; schizophrenia
ID CIGARETTE-SMOKING; PROLACTIN LEVELS; HIP FRACTURE; OSTEOPOROSIS;
   PREVALENCE; WOMEN; RISK; PATHOPHYSIOLOGY; RISPERIDONE; DEPRESSION
AB Schizophrenia affects about 1% of the world's population. Those with schizophrenia are at elevated risk of a variety of physical health conditions, including diabetes, coronary heart disease, hypertension and osteoporosis. Osteoporosis secondary to antipsychotic-induced hyperprolactinaemia (i.e. raised prolactin levels) has received little attention, when compared with reports on metabolic syndrome for instance. A recent study established that schizophrenia and prolactin-raising antipsychotic medication is directly associated with hip fractures. This is important and concerning as osteoporotic fractures are associated with much morbidity and mortality. This paper reviews the literature on antipsychotic-induced hyperprolactinaemia and its subsequent effects on bone mineral density.
RP Stubbs, B (corresponding author), Gallowgate House,Bedford Rd W, Northampton NN7 1HB, England.
EM brendonstubbs@hotmail.com
RI Stubbs, Brendon/X-1904-2018; Stubbs, Brendon/C-5696-2015
OI Stubbs, Brendon/0000-0001-7387-3791
CR [Anonymous], 2000, NIH Consens Statement, V17, P1
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NR 35
TC 25
Z9 28
U1 0
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1351-0126
EI 1365-2850
J9 J PSYCHIATR MENT HLT
JI J. Psychiatr. Ment. Health Nurs.
PD NOV
PY 2009
VL 16
IS 9
BP 838
EP 842
DI 10.1111/j.1365-2850.2009.01472.x
PG 5
WC Nursing; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Psychiatry
GA 505WE
UT WOS:000270729200008
PM 19824978
DA 2025-06-11
ER

PT J
AU Nowowiejska, J
   Baran, A
   Flisiak, I
AF Nowowiejska, Julia
   Baran, Anna
   Flisiak, Iwona
TI Sleep disorders in psoriasis
SO PRZEGLAD DERMATOLOGICZNY
LA English
DT Review
DE psoriasis; sleep; sleep disturbances; obstructive sleep apnea; restless
   leg syndrome
ID QUALITY-OF-LIFE; DISEASE
AB Psoriasis is a chronic inflammatory skin disease affecting 2-4% of general population. Skin lesions may be accompanied by pruritus or pain, what may cause difficulties in daily functioning, and also disturb sleep. Many patients suffer from depression, which is often accompanied by sleep disorders, usually insomnia. Psoriasis is also strongly associated with metabolic syndrome and obesity, but also with obstructive sleep apnea syndrome. Research also shows that patients with psoriasis more frequently suffer from restless leg syndrome. Sleep disorders lead to significant deterioration of patients' quality of life, which is already decreased by the disease itself. Therefore, it is advisable to screen patients with psoriasis for sleep disorders, and introduce adequate treatment early during the course of the disease.
C1 [Nowowiejska, Julia; Baran, Anna; Flisiak, Iwona] Med Univ Bialystok, Dept Dermatol & Venereol, Bialystok, Poland.
C3 Medical University of Bialystok
RP Baran, A (corresponding author), Uniwersytet Med, Klin Dermatol & Wenerol, Ul Zurawia 14, PL-15540 Bialystok, Poland.
EM anna.baran@umb.edu.pl
RI Flisiak, Iwona/R-5874-2018; Baran, Anna/T-6630-2018; Nowowiejska,
   Julia/AAR-6020-2021
OI Nowowiejska, Julia/0000-0002-6870-1167
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NR 29
TC 6
Z9 6
U1 0
U2 11
PU TERMEDIA PUBLISHING HOUSE LTD
PI POZNAN
PA KLEEBERGA ST 2, POZNAN, 61-615, POLAND
SN 0033-2526
EI 2084-9893
J9 PRZ DERMATOL
JI Prz. Dermatol.
PY 2020
VL 107
IS 3
BP 273
EP 280
DI 10.5114/dr.2020.97780
PG 8
WC Dermatology
WE Emerging Sources Citation Index (ESCI)
SC Dermatology
GA NJ2GT
UT WOS:000565864500007
OA gold
DA 2025-06-11
ER

PT J
AU Yang, LL
   Yang, HD
   He, MA
   Pan, A
   Li, XL
   Min, XW
   Zhang, C
   Xu, CW
   Zhu, XY
   Yuan, J
   Wei, S
   Miao, XP
   Hu, FB
   Wu, TC
   Zhang, XM
AF Yang, Liangle
   Yang, Handong
   He, Meian
   Pan, An
   Li, Xiulou
   Min, Xinwen
   Zhang, Ce
   Xu, Chengwei
   Zhu, Xiaoyan
   Yuan, Jing
   Wei, Sheng
   Miao, Xiaoping
   Hu, Frank B.
   Wu, Tangchun
   Zhang, Xiaomin
TI Longer Sleep Duration and Midday Napping Are Associated with a Higher
   Risk of CHD Incidence in Middle-Aged and Older Chinese: the
   Dongfeng-Tongji Cohort Study
SO SLEEP
LA English
DT Article
DE sleep duration; midday napping; incident CHD; prospective studies;
   follow-up
ID CORONARY-HEART-DISEASE; CAUSE-SPECIFIC MORTALITY;
   CARDIOVASCULAR-DISEASE; PHYSICAL-ACTIVITY; ALL-CAUSE; PSYCHOLOGICAL
   STRESS; METABOLIC SYNDROME; TASK-FORCE; FOLLOW-UP; WOMEN
AB Study Objectives: To analyze the independent and combined relations of sleep duration and midday napping with coronary heart diseases (CHD) incidence along with the underlying changes of cardiovascular disease (CVD) risk factors among Chinese adults.
   Methods: We included 19,370 individuals aged 62.8 years at baseline from September 2008 to June 2010, and they were followed until October 2013. Cox proportional hazards models and general linear models were used for multivariate longitudinal analyses.
   Results: Compared with sleeping 7-< 8 h/night, the hazard ratio (HR) of CHD incidence was 1.33 (95% CI = 1.10 to 1.62) for sleeping >= 10 h/night. The association was particularly evident among individuals who were normal weight and without diabetes. Similarly, the HR of incident CHD was 1.25 (95% CI = 1.05 to 1.49) for midday napping > 90 min compared with 1-30 min. When sleep duration and midday napping were combined, individuals having sleep duration >= 10 h and midday napping > 90 min were at a greater risk of CHD than those with sleeping 7-< 8 h and napping 1-30 min: the HR was 1.67 (95% CI = 1.04 to 2.66; P for trend = 0.017). In addition, longer sleep duration >= 10 h was significantly associated with increases in triglycerides and waist circumference, and a reduction in HDL-cholesterol; while longer midday napping > 90 min was related to increased waist circumference.
   Conclusions: Both longer sleep duration and midday napping were independently and jointly associated with a higher risk of CHD incidence, and altered lipid profile and waist circumference may partially explain the relationships.
C1 [Yang, Liangle; He, Meian; Zhu, Xiaoyan; Yuan, Jing; Wu, Tangchun; Zhang, Xiaomin] Huazhong Univ Sci & Technol, Dept Occupat & Environm Hlth, Wuhan 430030, Peoples R China.
   [Yang, Liangle; He, Meian; Zhu, Xiaoyan; Yuan, Jing; Wu, Tangchun; Zhang, Xiaomin] Huazhong Univ Sci & Technol, Minist Educ, Key Lab Environm & Hlth, Sch Publ Hlth,Tongji Med Coll, Wuhan 430030, Peoples R China.
   [Yang, Handong; Li, Xiulou; Min, Xinwen; Zhang, Ce; Xu, Chengwei] Dongfeng Motor Corp, Dongfeng Cent Hosp, Shiyan, Peoples R China.
   [Yang, Handong; Li, Xiulou; Min, Xinwen; Zhang, Ce; Xu, Chengwei] Hubei Univ Med, Shiyan, Peoples R China.
   [Pan, An; Wei, Sheng; Miao, Xiaoping] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Dept Epidemiol & Stat, Wuhan 430030, Peoples R China.
   [Xu, Chengwei] Wuhan Univ, Dept Cardiol, Renmin Hosp, Wuhan 430072, Peoples R China.
   [Hu, Frank B.] Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA.
   [Hu, Frank B.] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.
C3 Huazhong University of Science & Technology; Ministry of Education -
   China; Huazhong University of Science & Technology; Dongfeng Motor;
   Hubei University of Medicine; Huazhong University of Science &
   Technology; Wuhan University; Harvard University; Harvard T.H. Chan
   School of Public Health; Harvard University; Harvard T.H. Chan School of
   Public Health
RP Zhang, XM (corresponding author), Huazhong Univ Sci & Technol, Key Lab Environm & Hlth, Minist Educ, 13 Hangkong Rd, Wuhan 430030, Peoples R China.; Zhang, XM (corresponding author), Huazhong Univ Sci & Technol, Minist Environm Protect, 13 Hangkong Rd, Wuhan 430030, Peoples R China.; Zhang, XM (corresponding author), Huazhong Univ Sci & Technol, State Key Lab Environm Hlth Incubating, Sch Publ Hlth, Tongji Med Coll, 13 Hangkong Rd, Wuhan 430030, Peoples R China.
EM mingxz117@hust.edu.cn
RI XU, CHENGWEI/JCO-9076-2023; Zhang, Xiaomin/F-3206-2018; wei,
   sheng/E-9746-2012; yu, ye/KVB-7532-2024; Xiaoyan, Zhu/AGI-3291-2022; Hu,
   Frank/C-1919-2013; miao, xiaoping/C-4336-2011; Pan, An/C-5572-2011
OI Xiaoyan, Zhu/0000-0003-2246-2196; Min, Xinwen/0000-0002-8429-6560; miao,
   xiaoping/0000-0002-6818-9722; Pan, An/0000-0002-1089-7945
FU Natural National Scientific Foundation of China [81373093, 81230069,
   81390542]; 111 Project [B12004]; Program for Changjiang Scholars;
   Innovative Research Team in University of Ministry of Education of China
   [IRT1246]; China Medical Board [12-113]
FX This was not an industry supported study. This work was supported by the
   Natural National Scientific Foundation of China (81373093,81230069, and
   81390542), 111 Project (No. B12004); and the Program for Changjiang
   Scholars; Innovative Research Team in University of Ministry of
   Education of China (No. IRT1246); China Medical Board (No. 12-113). The
   authors have indicated no financial conflicts of interest.
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NR 39
TC 64
Z9 72
U1 1
U2 30
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
EI 1550-9109
J9 SLEEP
JI Sleep
PD MAR 1
PY 2016
VL 39
IS 3
BP 645
EP 652
AR PII sp-00311-15
DI 10.5665/sleep.5544
PG 8
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA DF1RB
UT WOS:000371115800019
PM 26564127
OA Green Published, Bronze
DA 2025-06-11
ER

EF﻿FN Clarivate Analytics Web of Science
VR 1.0
PT J
AU Wang, SH
   Du, QY
   Meng, XL
   Zhang, Y
AF Wang, Shaohui
   Du, Qinyun
   Meng, Xianli
   Zhang, Yi
TI Natural polyphenols: a potential prevention and treatment strategy for
   metabolic syndrome
SO FOOD & FUNCTION
LA English
DT Review
ID NF-KAPPA-B; ELLAGIC ACID PROTECTS; DIET-INDUCED OBESITY; BETA-D-GLUCOSE;
   OXIDATIVE STRESS; INSULIN-RESISTANCE; HEPATIC STEATOSIS; CAFFEIC ACID;
   ENDOTHELIAL-CELLS; GALLIC ACID
AB Metabolic syndrome (MS) is the term for a combination of hypertension, dyslipidemia, insulin resistance, and central obesity as factors leading to cardiovascular and metabolic disease. Epidemiological investigation has shown that polyphenol intake is negatively correlated with the incidence of MS. Natural polyphenols are widely found in cocoa beans, tea, vegetables, fruits, and some Chinese herbal medicines; they are a class of plant compounds containing a variety of phenolic structural units, which are potent antioxidants and anti-inflammatory agents in plants. Polyphenols are composed of flavonoids (such as flavanols, anthocyanidins, anthocyanins, isoflavones, etc.) and non-flavonoids (such as phenolic acids, stilbenes, and lignans). Modern pharmacological studies have proved that polyphenols can reduce blood pressure, improve lipid metabolism, lower blood glucose, and reduce body weight, thereby preventing and improving MS. Due to the unique characteristics and potential development and application value of polyphenols, this review summarizes some natural polyphenols that could treat MS, including their chemical properties, plant sources, and pharmacological action against MS, to provide a basis for the further study of polyphenols in MS.
C1 [Wang, Shaohui; Zhang, Yi] Chengdu Univ Tradit Chinese Med, Sch Ethn Med, State Key Lab Southwestern Chinese Med Resources, Chengdu, Peoples R China.
   [Du, Qinyun] Chengdu Univ Tradit Chinese Med, Sch Pharm, State Key Lab Southwestern Chinese Med Resources, Chengdu, Peoples R China.
   [Meng, Xianli] Chengdu Univ Tradit Chinese Med, Innovat Inst Chinese Med & Pharm, State Key Lab Southwestern Chinese Med Resources, Chengdu, Peoples R China.
C3 Chengdu University of Traditional Chinese Medicine; Chengdu University
   of Traditional Chinese Medicine; Chengdu University of Traditional
   Chinese Medicine
RP Zhang, Y (corresponding author), Chengdu Univ Tradit Chinese Med, Sch Ethn Med, State Key Lab Southwestern Chinese Med Resources, Chengdu, Peoples R China.; Meng, XL (corresponding author), Chengdu Univ Tradit Chinese Med, Innovat Inst Chinese Med & Pharm, State Key Lab Southwestern Chinese Med Resources, Chengdu, Peoples R China.
EM xlm999@cdutcm.edu.cn; zhangyi@cdutcm.edu.cn
RI Wang, Shaohui/HKO-6774-2023; Wang, Shengpeng/JOZ-1627-2023
OI Liu, Haibo/0000-0002-4213-2883
FU National Natural Science Foundation of China [82104534]; National Key
   R&D Program of China [2017YFC1703904]; "Xinglin Scholars" Research
   Promotion Program of Chengdu University of Traditional Chinese Medicine
   [BSH2021008]; Sichuan Province Science Research Special Funding Project
   for Postdoctoral Fellows [2022BSH044]
FX This study was supported by the National Natural Science Foundation of
   China (82104534), the National Key R&D Program of China
   (2017YFC1703904), the "Xinglin Scholars" Research Promotion Program of
   Chengdu University of Traditional Chinese Medicine (BSH2021008), and the
   Sichuan Province Science Research Special Funding Project for
   Postdoctoral Fellows (2022BSH044).
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NR 168
TC 51
Z9 54
U1 11
U2 63
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PD OCT 3
PY 2022
VL 13
IS 19
BP 9734
EP 9753
DI 10.1039/d2fo01552h
EA SEP 2022
PG 20
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA 5B1UD
UT WOS:000858372600001
PM 36134531
DA 2025-06-11
ER

PT J
AU Jing, F
   Mogi, M
   Horiuchi, M
AF Jing, Fei
   Mogi, Masaki
   Horiuchi, Masatsugu
TI Role of renin-angiotensin-aldosterone system in adipose tissue
   dysfunction
SO MOLECULAR AND CELLULAR ENDOCRINOLOGY
LA English
DT Review
DE Angiotensin II; Aldosterone; Adipose tissue; Metabolic sysdrome
ID INDUCED INSULIN-RESISTANCE; TYPE-1 RECEPTOR BLOCKERS; MINERALOCORTICOID
   RECEPTOR; METABOLIC SYNDROME; ADIPOCYTE DIFFERENTIATION;
   DIABETES-MELLITUS; PREADIPOSE CELLS; OXIDATIVE STRESS; GENE-EXPRESSION;
   AT(2) RECEPTOR
AB The renin-angiotensin-aldosterone system (RAAS) is known to be closely linked to the pathogenesis of insulin resistance. The angiotensin (Ang) II type 1 (AT(1)) receptor mediates the major effects of Ang II in adipose tissue, and blockade of the AT(1) receptor improves insulin sensitivity, with enhanced adipocyte differentiation. In contrast, the role of angiotensin type 2 (AT(2)) receptor activation in insulin sensitivity is still controversial, although AT(2) receptor functions are thought to be mutually antagonistic against those of the AT(1) receptor in the cardiovascular system. Aldosterone exerts its biological roles via the mineral-corticoid receptor (MR), and inhibition of MR signaling in adipose tissue ameliorates inflammation, with upregulation of insulin-mediated glucose transport and adipocyte differentiation. Clinical studies indicate that blockade of RAAS prevents the new onset of type 2 diabetes and improves the metabolic syndrome in diabetic patients. We here review the recent concepts of the roles of RAAS in adipose tissue. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
C1 [Jing, Fei; Mogi, Masaki; Horiuchi, Masatsugu] Ehime Univ, Dept Mol Cardiovasc Biol & Pharmacol, Grad Sch Med, Tohon, Ehime 7910295, Japan.
C3 Ehime University
RP Horiuchi, M (corresponding author), Ehime Univ, Dept Mol Cardiovasc Biol & Pharmacol, Grad Sch Med, Tohon, Ehime 7910295, Japan.
EM horiuchi@m.ehime-u.ac.jp
RI Mogi, Masaki/ABH-2011-2020
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NR 74
TC 37
Z9 40
U1 1
U2 5
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0303-7207
J9 MOL CELL ENDOCRINOL
JI Mol. Cell. Endocrinol.
PD SEP 25
PY 2013
VL 378
IS 1-2
SI SI
BP 23
EP 28
DI 10.1016/j.mce.2012.03.005
PG 6
WC Cell Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Endocrinology & Metabolism
GA 242CC
UT WOS:000326214000003
PM 22465098
DA 2025-06-11
ER

PT J
AU Hashemi, M
   Kordi-Tamandani, DM
   Sharifi, N
   Moazeni-Roodi, A
   Kaykhaei, MA
   Narouie, B
   Torkmanzehi, A
AF Hashemi, Mohammad
   Kordi-Tamandani, Dor Mohammad
   Sharifi, Nooshin
   Moazeni-Roodi, Abdolkarim
   Kaykhaei, Mahmoud-Ali
   Narouie, Behzad
   Torkmanzehi, Adam
TI Serum paraoxonase and arylesterase activities in metabolic syndrome in
   Zahedan, southeast Iran
SO EUROPEAN JOURNAL OF ENDOCRINOLOGY
LA English
DT Article
ID CARDIOVASCULAR-DISEASE; RHEUMATOID-ARTHRITIS; DIABETES-MELLITUS;
   OXIDATIVE STRESS; POLYMORPHISM; CORONARY; RISK; GENE
AB Objective: Paraoxonase (PON) is associated with high-density lipoprotein and protects serum lipid from oxidation. The aim of this study was to determine serum PON, arylesterase (ARE) activities, and total antioxidant capacity (TAC) in metabolic syndrome (MES).
   Methods: This case-control study was performed on 106 patients with MES and 231 healthy subjects. Serum PON and ARE activities were determined spectrophotometrically. TAC was determined using ferric reducing ability of plasma assay.
   Results: The results showed that serum PON activity was significantly lower in patients with MES (69.62 +/- 59.86 IU/l) than healthy subjects (91.64 +/- 77.45 IU/l) (P<0.05). The serum ARE activity in MES and normal subjects were 45.23 +/- 23.24 and 65.69 +/- 31.10 kU/l respectively. The ARE activity was significantly lower in patients with MES than normal subjects (P<0.0001). No significant differences were observed between MES and normal subjects regarding TAC.
   Conclusion: The lower PON and ARE activities in MES may be considered an independent risk factor for cardiovascular disease, which remains to be cleared. European Journal of Endocrinology 164 219-222
C1 [Hashemi, Mohammad] Zahedan Univ Med Sci, Dept Clin Biochem, Sch Med, Zahedan 9816743175, Iran.
   [Kordi-Tamandani, Dor Mohammad; Sharifi, Nooshin; Torkmanzehi, Adam] Univ Sistan & Baluchestan, Dept Biol, Fac Sci, Zahedan 98155987, Iran.
   [Moazeni-Roodi, Abdolkarim] Zahedan Univ Med Sci, Res Ctr Infect Dis & Trop Med, Zahedan 9816743175, Iran.
   [Kaykhaei, Mahmoud-Ali; Narouie, Behzad] Zahedan Univ Med Sci, Dept Internal Med, Sch Med, Zahedan 9816743175, Iran.
C3 Zahedan University of Medical Sciences; University of Sistan &
   Baluchestan; Zahedan University of Medical Sciences; Zahedan University
   of Medical Sciences
RP Hashemi, M (corresponding author), Zahedan Univ Med Sci, Dept Clin Biochem, Sch Med, Zahedan 9816743175, Iran.
EM mhd.hashemi@gmail.com
RI Mohammad, Dor/AGT-2048-2022; narouie, behzad/ABC-3389-2020; Kaykhaei,
   Mahmoud Ali/F-8801-2011; hashemi, Mohammad/H-2446-2016; Moazeni-roodi,
   Abdolkarim/F-9845-2017
OI Kordi Tamanadani, Dor Mohammad/0000-0002-4358-4785; Kaykhaei, Mahmoud
   Ali/0000-0003-2994-4243; hashemi, Mohammad/0000-0002-6074-7101;
   Moazeni-roodi, Abdolkarim/0000-0002-3561-0592
FU Zahedan University of Medical Sciences
FX This project was supported by a research grant from Zahedan University
   of Medical Sciences.
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NR 25
TC 17
Z9 19
U1 0
U2 5
PU BIOSCIENTIFICA LTD
PI BRISTOL
PA EURO HOUSE, 22 APEX COURT WOODLANDS, BRADLEY STOKE, BRISTOL BS32 4JT,
   ENGLAND
SN 0804-4643
J9 EUR J ENDOCRINOL
JI Eur. J. Endocrinol.
PD FEB
PY 2011
VL 164
IS 2
BP 219
EP 222
DI 10.1530/EJE-10-0881
PG 4
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 707UY
UT WOS:000286315500009
PM 21059866
DA 2025-06-11
ER

PT J
AU Grant, P
   Jackson, G
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   Quin, J
AF Grant, Paul
   Jackson, Graham
   Baig, Irfan
   Quin, John
TI Erectile dysfunction in general medicine
SO CLINICAL MEDICINE
LA English
DT Article
ID TESTOSTERONE CONCENTRATIONS; RISK; MEN
AB Erectile dysfunction (ED) affects millions of men worldwide with implications that go far beyond sexual activity. ED is now recognised as an early marker of cardiovascular disease, diabetes mellitus (DM) and depression. The risk factors that are associated with ED (sedentary lifestyle, obesity, smoking, hypercholesterolaemia and the metabolic syndrome) are very similar to those for cardiovascular disease (CVD). Arguably, the awareness of ED as a symptomatic entity in the post-Viagra (TM) age is on the rise. Nevertheless, ED is commonly missed when evaluating patients in the hospital setting, either because of lack of consideration or awareness, or through simple embarrassment (of both clinician and patient). This article provides an overview of the aetiology, assessment and importance of ED and hopes to promote its consideration in day-to-day clinical practice.
C1 [Grant, Paul] Maidstone & Tunbridge Wells Hosp Trust, Maidstone, Kent, England.
   [Jackson, Graham] London Bridge Hosp, London, England.
   [Baig, Irfan; Quin, John] Royal Sussex Cty Hosp, Brighton, E Sussex, England.
C3 University of Brighton
RP Grant, P (corresponding author), Maidstone Hlth Author, Dept Endocrinol & Diabet, Hermitage Lane, Maidstone ME16 9QQ, Kent, England.
EM drpaul.grant@doctors.org.uk
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NR 29
TC 23
Z9 26
U1 0
U2 11
PU ROY COLL PHYS LONDON EDITORIAL OFFICE
PI LONDON
PA 11 ST ANDREWS PLACE REGENTS PARK, LONDON NW1 4LE, ENGLAND
SN 1470-2118
EI 1473-4893
J9 CLIN MED
JI Clin. Med.
PD APR
PY 2013
VL 13
IS 2
BP 136
EP 140
DI 10.7861/clinmedicine.13-2-136
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 122JQ
UT WOS:000317314800005
PM 23681859
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Harrell, CS
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   McFarlane, D.
   Hyer, M. M.
   Stein, D.
   Sayeed, I.
   Neigh, G. N.
TI High-fructose diet during adolescent development increases
   neuroinflammation and depressive-like behavior without exacerbating
   outcomes after stroke
SO BRAIN BEHAVIOR AND IMMUNITY
LA English
DT Article
DE Affective-like behavior; Complement; Fructose; Adolescence; Stroke
ID FEMALE CALIFORNIA MICE; ISCHEMIC-STROKE; OXIDATIVE STRESS; ENDURING
   CONSEQUENCES; FUNCTIONAL RECOVERY; COMPLEMENT CASCADE;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; ANXIETY-LIKE; AGED RATS
AB Diseases, disorders, and insults of aging are frequently studied in otherwise healthy animal models despite rampant co-morbidities and exposures among the human population. Stressor exposures can increase neuroinflammation and augment the inflammatory response following a challenge. The impact of dietary exposure on baseline neural function and behavior has gained attention; in particular, a diet high in fructose can increase activation of the hypothalamic-pituitary-adrenal axis and alter behavior. The current study considers the implications of a diet high in fructose for neuroinflammation and outcomes following the cerebrovascular challenge of stroke. Ischemic injury may come as a "second hit" to pre-existing metabolic pathology, exacerbating inflammatory and behavioral sequelae. This study assesses the neuroinflammatory consequences of a pea adolescent high-fructose diet model and assesses the impact of diet-induced metabolic dysfunction on behavioral and neuropathological outcomes after middle cerebral artery occlusion. We demonstrate that consumption of a high-fructose diet initiated during adolescent development increases brain complement expression, elevates plasma TNF alpha and serum corticosterone, and promotes depressive-like behavior. Despite these adverse effects of diet exposure, pen-adolescent fructose consumption did not exacerbate neurological behaviors or lesion volume after middle cerebral artery occlusion.
C1 [Harrell, C. S.; Zainaldin, C.; McFarlane, D.; Neigh, G. N.] Emory Univ, Sch Med, Dept Physiol, Atlanta, GA 30322 USA.
   [Stein, D.; Sayeed, I.] Emory Univ, Sch Med, Dept Emergency Med, Atlanta, GA 30322 USA.
   [Hyer, M. M.; Neigh, G. N.] Virginia Commonwealth Univ, Dept Anat & Neurobiol, 1101 East Marshall St, Richmond, VA 23298 USA.
C3 Emory University; Emory University; Virginia Commonwealth University
RP Neigh, GN (corresponding author), Virginia Commonwealth Univ, Dept Anat & Neurobiol, 1101 East Marshall St, Richmond, VA 23298 USA.
EM gretchen.mccandless@vcuhealth.org
RI Neigh, Gretchen/AAW-5691-2020; Stein, Donald/AAJ-5139-2020; Neigh,
   Gretchen/G-3662-2011
OI McFarlane, Danielle/0009-0008-3149-7781; Neigh,
   Gretchen/0000-0003-0955-9161; Harrell Shreckengost, Constance
   S./0000-0001-5229-0140; Hyer, Molly/0000-0001-7687-2030
FU National Institutes of Health [R21MH091321-01]; American Heart
   Association Predoctoral Fellowship [14PRE18910002]; Virginia
   Commonwealth Department of Anatomy and Neurobiology; National Institute
   of Health Institutional Research and Academic Career Development Award
   [K12GM093857]; American Heart Association (AHA) [14PRE18910002] Funding
   Source: American Heart Association (AHA)
FX The authors would like to acknowledge Bushra Wali, PhD, Christina
   Nemeth, PhD, Sean Kelly, and Leah Vaughan for their technical
   assistance. Funding for the studies in this manuscript was provided by
   the National Institutes of Health R21MH091321-01 (GNN), the American
   Heart Association Predoctoral Fellowship (14PRE18910002; CSH), Virginia
   Commonwealth Department of Anatomy and Neurobiology (GNN), and the
   National Institute of Health Institutional Research and Academic Career
   Development Award (K12GM093857; MMH).
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NR 70
TC 24
Z9 26
U1 0
U2 8
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0889-1591
EI 1090-2139
J9 BRAIN BEHAV IMMUN
JI Brain Behav. Immun.
PD OCT
PY 2018
VL 73
BP 340
EP 351
DI 10.1016/j.bbi.2018.05.018
PG 12
WC Immunology; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Neurosciences & Neurology; Psychiatry
GA GU6QO
UT WOS:000445440900036
PM 29787857
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Han, KM
   Kim, MS
   Kim, A
   Paik, JW
   Lee, J
   Ham, BJ
AF Han, Kyu-Man
   Kim, Mm Sun
   Kim, Aram
   Paik, Jong-Woo
   Lee, Juneyoung
   Ham, Byung-Joo
TI Chronic medical conditions and metabolic syndrome as risk factors for
   incidence of major depressive disorder: A longitudinal study based on
   4.7 million adults in South Korea
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Major depressive disorder; Metabolic syndrome; Physical illness;
   Longitudinal; Risk factors
ID MIDDLE-AGED ADULTS; CARDIOVASCULAR-DISEASE; PHYSICAL-ACTIVITY;
   MENTAL-DISORDERS; MOOD DISORDERS; BLOOD-PRESSURE; SYMPTOMS; ASSOCIATION;
   ANXIETY; PREVALENCE
AB Background: The assessment of comorbid physical illness and metabolic or cardiovascular risk factors as potential risk factors for onset of major depressive disorder (MDD) is crucial. We aimed to investigate potential risk factors for the development of MDD among individuals with chronic medical conditions and metabolic and behavioral risk factors using a large population-based retrospective cohort from the data of the National Health Insurance Service (NHIS) in South Korea.
   Methods: The population-based retrospective cohort included data from 2,370,815 adults (age >= 20 years) diagnosed with MDD between January 1, 2010, and December 31, 2016 and age- and gender-matched 2,370,815 healthy controls obtained from the claims data of the NHIS. The data of the regular health checkup provided by the NHIS were also included (age >= 40 years). Logistic regression analyses were performed to investigate the potential risk factors for the incidence of MDD.
   Results: Chronic medical conditions such as Parkinson's disease (odds ratio [OR] = 7.808, 95% confidence interval [CI] = 7.517-8.11), epilepsy (OR = 6.119, 95% CI = 6.019-6.22), multiple sclerosis (OR = 5.532, 95% CI = 4.976-6.151), Huntington's disease (OR = 5.387, 95% CI = 3.258-8.909), migraine (OR = 4.374, 95% CI = 4.341-4.408), stroke (OR = 4.074, 95% CI = 4.032-4.117), and cancer; metabolic syndrome (OR = 1.049, 95% CI = 1.041-1.057) and several of its components including central obesity, elevated fasting blood glucose and triglyceride levels, and reduced high-density lipoprotein level; and cigarette smoking, frequent alcohol consumption, and low physical activity are potential risk factors for the development of MDD.
   Conclusion: Our results may support previous evidence on the association between physical conditions and the incidence of MDD as reported by individual population-based studies with modest sample sizes.
C1 [Han, Kyu-Man; Ham, Byung-Joo] Korea Univ, Coll Med, Dept Psychiat, Anam Hosp, 73 Inchon Ro, Seoul 02841, South Korea.
   [Kim, Mm Sun; Lee, Juneyoung] Korea Univ, Coll Med, Dept Biostat, Seoul, South Korea.
   [Kim, Aram; Ham, Byung-Joo] Korea Univ, Coll Med, Dept Biomed Sci, Seoul, South Korea.
   [Paik, Jong-Woo] Kyung Hee Univ, Coll Med, Dept Psychiat, Seoul, South Korea.
C3 Korea University; Korea University Medicine (KU Medicine); Korea
   University; Korea University Medicine (KU Medicine); Korea University;
   Korea University Medicine (KU Medicine); Kyung Hee University
RP Ham, BJ (corresponding author), Korea Univ, Coll Med, Dept Psychiat, Anam Hosp, 73 Inchon Ro, Seoul 02841, South Korea.
EM hambj@korea.ac.kr
RI Ham, Byung-Joo/S-9982-2019; LEE, HYUN/D-6482-2016; PAIK,
   JONG-WOO/C-2177-2016
OI Han, Kyu-Man/0000-0002-1982-4216; Lee, Juneyoung/0000-0001-8073-9304;
   Ham, Byung Joo/0000-0002-0108-2058
FU Bio & Medical Technology Development Program of the National Research
   Foundation (NRF) - Ministry of Science, ICT & Future Planning
   [NRF-2016M3A9A7916996]; Research Program To Solve Social Issues of the
   National Research Foundation of Korea (NRF) - Ministry of Science and
   ICT [NRF-2017R1A2B4002090]
FX This research was supported by the Bio & Medical Technology Development
   Program of the National Research Foundation (NRF) funded by the Ministry
   of Science, ICT & Future Planning (NRF-2016M3A9A7916996) and the
   Research Program To Solve Social Issues of the National Research
   Foundation of Korea (NRF) funded by the Ministry of Science and ICT
   (NRF-2017R1A2B4002090). The funding agency had no role in the study
   design, data collection and analysis, decision to publish, or
   preparation of the manuscript.
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NR 81
TC 34
Z9 37
U1 1
U2 23
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD OCT 1
PY 2019
VL 257
BP 486
EP 494
DI 10.1016/j.jad.2019.07.003
PG 9
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA IS8CQ
UT WOS:000482376300061
PM 31319340
DA 2025-06-11
ER

PT J
AU de Cavanagh, EMV
   Inserra, F
   Ferder, M
   Ferder, L
AF de Cavanagh, E. M. V.
   Inserra, F.
   Ferder, M.
   Ferder, L.
TI From mitochondria to disease: Role of the renin-angiotensin system
SO AMERICAN JOURNAL OF NEPHROLOGY
LA English
DT Review
DE aging; oxidative stress; angiotensin II; mitochondria; hypertension;
   renin-angiotensin system; cardiovascular disease; kidney; diabetes;
   reactive oxygen species
ID SPONTANEOUSLY HYPERTENSIVE-RATS; TUMOR-NECROSIS-FACTOR; NITRIC-OXIDE;
   ENDOTHELIAL-CELLS; OXIDATIVE STRESS; SUPEROXIDE-PRODUCTION;
   HYDROGEN-PEROXIDE; INDUCED APOPTOSIS; ACE-INHIBITORS;
   SUCCINATE-DEHYDROGENASE
AB Mitochondria are energy-producing organelles that conduct other key cellular tasks. Thus, mitochondrial damage may impair various aspects of tissue functioning. Mitochondria generate oxygen-and nitrogen-derived oxidants, being themselves major oxidation targets. Dysfunctional mitochondria seem to contribute to the pathophysiology of hypertension, cardiac failure, the metabolic syndrome, obesity, diabetes mellitus, renal disease, atherosclerosis, and aging. Mitochondrial proteins and metabolic intermediates participate in various cellular processes, apart from their well-known roles in energy metabolism. This emphasizes the participation of dysfunctional mitochondria in disease, notwithstanding that most evidences supporting this concept come from animal and cultured-cell studies. Mitochondrial oxidant production is altered by several factors related to vascular pathophysiology. Among these, angiotensin-II stimulates mitochondrial oxidant release leading to energy metabolism depression. By lowering mitochondrial oxidant production, angiotensin-II inhibition enhances energy production and protects mitochondrial structure. This seems to be one of the mechanisms underlying the benefits of angiotensinII inhibition in hypertension, diabetes, and aging rodent models. If some of these findings can be reproduced in humans, they would provide a new perspective on the implications that RAS-blockade can offer as a therapeutic strategy. This review intends to present available information pointing to mitochondria as targets for therapeutic Ang-II blockade in human renal and CV disease. Copyright (C) 2007 S. Karger AG, Basel.
C1 Ponce Sch Med, Dept Physiol & Pharmacol, Ponce, PR 00732 USA.
   Univ Buenos Aires, Sch Med, Cardiovasc Res Inst, Lab Expt Nephrol, Buenos Aires, DF, Argentina.
C3 University of Buenos Aires; Instituto Cardiovascular de Buenos Aires
   (ICBA)
RP de Cavanagh, EMV (corresponding author), Ponce Sch Med, Dept Physiol & Pharmacol, POB 7004, Ponce, PR 00732 USA.
EM leferder@psm.edu
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NR 110
TC 108
Z9 121
U1 0
U2 13
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0250-8095
EI 1421-9670
J9 AM J NEPHROL
JI Am. J. Nephrol.
PY 2007
VL 27
IS 6
BP 545
EP 553
DI 10.1159/000107757
PG 9
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 219OK
UT WOS:000250094300001
PM 17785964
OA Bronze
DA 2025-06-11
ER

PT J
AU Wang, S
   Zhang, L
   Wu, YG
   Ma, J
AF Wang, Si
   Zhang, Lin
   Wu, Yigao
   Ma, Jun
TI Clinical Patterns of Metabolic Syndrome in First-Hospitalized Major
   Depressive Disorder Patients: Comparison of Antidepressant-Exposed and
   Drug-Naïve Groups
SO NEUROPSYCHIATRIC DISEASE AND TREATMENT
LA English
DT Article
DE major depressive disorder; metabolic syndrome; antidepressant-exposed;
   drug-na & iuml;ve; risk factor
ID PROSPECTIVE ASSOCIATIONS; LIFE-STYLE; PREVALENCE; ANXIETY; HEALTH;
   ABNORMALITIES; OVERWEIGHT; SEVERITY; SYMPTOMS; OBESITY
AB Background: Major depressive disorder (MDD) and metabolic syndrome (MetS) are both major health threats nowadays, and the relationship between them is complex and close. The purpose of this paper is to compare differences in the prevalence and risk factors of MetS in first hospitalized patients with MDD with and without antidepressant exposure. Methods: A total of 636 first hospitalized MDD patients (study group) with antidepressant exposure and 345 drug-na & iuml;ve patients (control group) were included in this study. Their socio-demographic data, routine biochemical indices, and psychological symptom assessment were collected. Results: There was no difference in the prevalence of MetS between the study group and the control group (F = 2.49, p = 0.115). Factors affecting MetS and its severity differed between the two groups, in the study group, the identified risk factors for MetS were onset age (B = 0.05, p <0.001, OR = 1.05, 95% CI = 1.02-1.08), TSH level (B = 0.42, p <0.001, OR = 1.53, 95% CI = 1.39-1.68). Meanwhile, in the control group, the identified risk factors for MetS were more extensive and they were, onset age (B = 0.11, p <0.001, OR = 1.12, 95% CI = 1.07-1.16), suicidal behavior (B = 1.54, p = 0.007, OR = 4.65, 95% CI = 1.51-14.33), HAMD scores (B = 0.23, p = 0.008, OR = 1.26, 95% CI = 1.06-1.49) and TSH levels (B = 0.33, p <0.001, OR = 1.39, 95% CI = 1.17-1.65). The number of risk factors identified was lower in the study group. Conclusion: Antidepressant use was associated with greater MetS severity but did not affect overall prevalence. Antidepressants appear to modify MetS risk factors, highlighting the need to differentiate these effects from those in drug-na & iuml;ve patients when developing MetS interventions for the MDD population.
C1 [Wang, Si; Zhang, Lin; Ma, Jun] Wuhan Mental Hlth Ctr, Dept Psychiat, 89 Gongnongbing Rd, Wuhan, Hubei, Peoples R China.
   [Wang, Si; Zhang, Lin; Ma, Jun] Wuhan Hosp Psychotherapy, Dept Psychiat, Wuhan, Peoples R China.
   [Wu, Yigao] First Affiliated Hosp, Wannan Med Coll, Dept Med Psychol, 2 Zheshan West Rd, Wuhu, Peoples R China.
C3 Wannan Medical College
RP Ma, J (corresponding author), Wuhan Mental Hlth Ctr, Dept Psychiat, 89 Gongnongbing Rd, Wuhan, Hubei, Peoples R China.; Wu, YG (corresponding author), First Affiliated Hosp, Wannan Med Coll, Dept Med Psychol, 2 Zheshan West Rd, Wuhu, Peoples R China.
EM wuyigao2000@126.com; majun0313@wo.cn
RI Ma, Jun/HLV-7600-2023
OI Ma, Jun/0000-0001-5633-6839; Wu, Yigao/0000-0001-6706-0436
FU Key projects of Anhui Humanities and Social Sciences Research Base
   [SK2019A0226]; Japanese Mental Health Okamoto Memorial Foundation
   Research Assistance Project
FX This work was supported by Key projects of Anhui Humanities and Social
   Sciences Research Base (SK2019A0226 to YW: PI) and Japanese Mental
   Health Okamoto Memorial Foundation Research Assistance Project (Heisei
   31 Research 3 to YW: PI) .
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NR 44
TC 0
Z9 0
U1 0
U2 1
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
EI 1178-2021
J9 NEUROPSYCH DIS TREAT
JI Neuropsychiatr. Dis. Treat.
PY 2024
VL 20
BP 2159
EP 2168
DI 10.2147/NDT.S494619
PG 10
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Psychiatry
GA M4G4W
UT WOS:001357142800001
PM 39564596
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Corona, G
   Mannucci, E
   Schulman, C
   Petrone, L
   Mansani, R
   Cilotti, A
   Balercia, G
   Chiarini, V
   Forti, G
   Maggi, M
AF Corona, Giovanni
   Mannucci, Edoardo
   Schulman, Claude
   Petrone, Luisa
   Mansani, Riccardo
   Cilotti, Antonio
   Balercia, Giancarlo
   Chiarini, Valerio
   Forti, Gianni
   Maggi, Mario
TI Psychobiologic correlates of the metabolic syndrome and associated
   sexual dysfunction
SO EUROPEAN UROLOGY
LA English
DT Article
DE erectile dysfunction; hypogonadism; metabolic syndrome; SIEDY;
   testosterone
ID ERECTILE DYSFUNCTION; INSULIN-RESISTANCE; RISK-FACTORS; TESTOSTERONE;
   MEN; PREVALENCE; ANDROGENS; HYPOGONADISM; OBESITY; ONSET
AB Objectives: The association of low testosterone level and erectile dysfunction (ED) with metabolic syndrome (MS) is receiving increasing attention. The present study determined the psychobiologic characteristics of sexual dysfunction (SD) associated with MS (as defined by the National Cholesterol Education Program's Adult Treatment Panel III criteria) in a series of 803 consecutive male outpatients.
   Methods: Several hormonal, biochemical, and instrumental (penile Doppler ultrasound [PDU]) parameters were studied, along with general psychopathology scores (Middlesex Hospital Questionnaire modified [MHQ]). The Structured Interview on Erectile Dysfunction (SIEDY) was also applied.
   Results: Among the 236 patients (29.4%) diagnosed as having a MS, 96.5% reported ED, 39.6% hypoactive sexual desire (HSD), 22.7% premature ejaculation, and 4.8% delayed ejaculation. Patients with MS were characterised by greater subjective (as assessed by SIEDY) and objective (as assessed by PDU) ED and by greater somatised anxiety than the rest of the sample. The prevalence of overt hypogonadism (total testosterone < 8 nM) was significantly higher in patients with MS. Among MS components, waist circumference and hyperglycaemia were the best predictors of hypogonadism. Hypogonadal patients with MS showed higher gonadotropin and lower free testosterone levels, suggesting a primary hypogonadism. Among patients with MS, hypogonadism was present in 11.9% and 3.8% in the rest of the sample (p < 0.0001) and was associated with typical hypogonadism-related symptoms, such as hypoactive sexual desire, low frequency of sexual intercourse, and depressive symptoms.
   Conclusions: Our data suggest that MS is associated with a more severe ED and induces somatisation. Furthermore, MS is associated with a higher prevalence of hypogonadism in patients with SD. The presence of hypogonadism can further exacerbate the MS-associated sexual dysfunction, adding the typical hypogonadisin-related symptoms (including HSD, 66.7%). Recognising MS associated with hypogonadism is important for both sexual and general health and its serious potential associated risks. (c) 2006 European Association of Urology. Published by Elsevier B.V. All rights reserved.
C1 Univ Florence, Androl Unit, Dept Clin Physiopathol, I-50139 Florence, Italy.
   Univ Florence, Diabet Sect, Geriat Unit, Dept Crit Care, I-50139 Florence, Italy.
   Univ Clin Brussels, Erasme Hosp, Dept Urol, Brussels, Belgium.
   Polytech Univ Marche, Endocrinol Unit, Ancona, Italy.
   Maggiore Bellaria Hosp, Endocrinol Unit, Bologna, Italy.
C3 University of Florence; University of Florence; Universite Libre de
   Bruxelles; Marche Polytechnic University; AUSL di Bologna
RP Maggi, M (corresponding author), Univ Florence, Androl Unit, Dept Clin Physiopathol, Viale Pieraccini 6, I-50139 Florence, Italy.
EM m.maggi@dfc.unifi.it
RI Petrone, Luisa/L-1805-2018; Maggi, Mario/AAB-8284-2019; Mannucci,
   Edoardo/K-6749-2016
OI Mannucci, Edoardo/0000-0001-9759-9408; MAGGI, Mario/0000-0003-3267-4221
CR Apfelbaum B, 2000, PRINCIPLES AND PRACTICE OF SEX THERAPY, THIRD EDITION, P205
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NR 42
TC 150
Z9 160
U1 0
U2 3
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0302-2838
EI 1873-7560
J9 EUR UROL
JI Eur. Urol.
PD SEP
PY 2006
VL 50
IS 3
BP 595
EP 604
DI 10.1016/j.eururo.2006.02.053
PG 10
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 079YU
UT WOS:000240214600034
PM 16564129
DA 2025-06-11
ER

PT J
AU Rolla, AR
AF Rolla, Arturo R.
TI Addressing the Need to Tailor Treatment to the Spectrum of Type 2
   Diabetes: New Perspectives
SO DIABETES TECHNOLOGY & THERAPEUTICS
LA English
DT Review
ID METABOLIC SYNDROME; CARDIOVASCULAR-DISEASE; MORTALITY; INSULIN;
   MELLITUS; RISK; COMPLICATIONS; EPIDEMIOLOGY; HYPOGLYCEMIA; DEPRESSION
AB Type 2 diabetes mellitus is characterized by the progressive loss of beta cell function, which occurs after many years of insulin resistance. Within this definition, clinicians may see a diverse array of presentations, suggesting different proportions of these two pathogenic factors and a complex etiology. There are also differences in the rate of type 2 diabetes progression in each patient, so treatments must be reviewed frequently to respond to changing severity of pathophysiologies. This article first considers some of the heritable factors and the pathogenic heterogeneity of type 2 diabetes. Relevant socioeconomic and demographic factors influencing disease development are reviewed after that, while emphasizing how a patient's treatment requires changes over time.
C1 Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA.
C3 Harvard University; Harvard University Medical Affiliates; Beth Israel
   Deaconess Medical Center; Harvard Medical School
RP Rolla, AR (corresponding author), Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, 110 Francis St,Suite 2F, Boston, MA 02215 USA.
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NR 41
TC 1
Z9 2
U1 0
U2 1
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1520-9156
EI 1557-8593
J9 DIABETES TECHNOL THE
JI Diabetes Technol. Ther.
PD MAY
PY 2009
VL 11
IS 5
BP 267
EP 274
DI 10.1089/dia.2008.0075
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 444DD
UT WOS:000265959700001
PM 19425874
DA 2025-06-11
ER

PT J
AU Stanhope, KK
   Kramer, MR
AF Stanhope, Kaitlyn K.
   Kramer, Michael R.
TI Association Between Recommended Preconception Health Behaviors and
   Screenings and Improvements in Cardiometabolic Outcomes of Pregnancy
SO PREVENTING CHRONIC DISEASE
LA English
DT Article
ID ASSESSMENT MONITORING-SYSTEM; FACTOR SURVEILLANCE SYSTEM; INDICATORS;
   DISPARITIES; VALIDATION; MORTALITY
AB Introduction
   Gestational diabetes (GDM) and hypertensive disorders of pregnancy (HDP) are associated with increased risk of maternal and infant illness and long-term elevated cardiometabolic risk. Little information exists on the prevention of either disorder before pregnancy. Our goal was to describe the association between preconception indicators and risk of gestational diabetes and hypertensive disorders of pregnancy.
   Methods
   We used logistic regression to analyze cross-sectional data from the 2016-2017 Pregnancy Risk Assessment Monitoring System (N = 68,493) to quantify the association between 14 preconception health indicators (across domains of health care, nutrition and physical activity, tobacco and alcohol, chronic conditions, mental health, and emotional and social support) and, separately, GDM and HDP. We accounted for sampling weights and controlled for maternal age, race/ethnicity, prepregnancy insurance, prepregnancy body mass index, and report of a check-up in the year before pregnancy.
   Results
   Prepregnancy obesity was the strongest predictor of both HDP (adjusted odds ratio [aOR], 3.1; 95% CI, 2.8-3.5) and GDM (aOR, 3.1; 95% CI, 2.7-3.5). Individual behaviors (eg, exercise, attending a check-up) were not associated with either HDP or GDM. A diagnosis of diabetes before pregnancy predicted HDP (aOR, 2.3; 95% CI, 1.7-3.0).
   Conclusion
   Prepregnancy chronic disease and obesity predicted pregnancy complications (ie, GDM and HDP). Given the challenges in reversing these conditions in the year before pregnancy, efforts to improve preconception health may be best directed broadly to expand access to primary care for all women.
C1 [Stanhope, Kaitlyn K.] Emory Univ, Sch Med, Dept Gynecol & Obstet, Atlanta, GA USA.
   [Kramer, Michael R.] Emory Univ, Dept Epidemiol, Atlanta, GA USA.
C3 Emory University; Emory University
RP Stanhope, KK (corresponding author), Dept Gynecol & Obstet, Div Res, Atlanta, GA 30303 USA.
EM Kaitlyn.keirsey.stanhope@emory.edu
RI Kerisey, Kaitlyn/ABE-5436-2021
OI Stanhope, Kaitlyn/0000-0003-1540-3059
FU Health Resources and Services Administration Maternal and Child Health
   Bureau [T03MC07651]
FX Thank you to the CDC PRAMS Working Group and PRAMS participating states
   and respondents. This work was supported in part by Health Resources and
   Services Administration Maternal and Child Health Bureau, award no.
   T03MC07651. No copyrighted materials or tools were used in this
   research.
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NR 30
TC 5
Z9 7
U1 0
U2 2
PU CENTERS  DISEASE CONTROL & PREVENTION
PI ATLANTA
PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA
SN 1545-1151
J9 PREV CHRONIC DIS
JI Prev. Chronic Dis.
PD JAN
PY 2021
VL 18
AR E06
DI 10.5888/pcd18.200481
PG 9
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA QH4LV
UT WOS:000618248600006
PM 33476258
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Bammann, K
   Gwozdz, W
   Pischke, C
   Eiben, G
   Fernandez-Alvira, JM
   De Henauw, S
   Lissner, L
   Moreno, LA
   Pitsiladis, Y
   Reisch, L
   Veidebaum, T
   Pigeot, I
AF Bammann, K.
   Gwozdz, W.
   Pischke, C.
   Eiben, G.
   Fernandez-Alvira, J. M.
   De Henauw, S.
   Lissner, L.
   Moreno, L. A.
   Pitsiladis, Y.
   Reisch, L.
   Veidebaum, T.
   Pigeot, I.
CA IDEFICS Consortium
TI The impact of familial, behavioural and psychosocial factors on the SES
   gradient for childhood overweight in Europe. A longitudinal study
SO INTERNATIONAL JOURNAL OF OBESITY
LA English
DT Article
ID CARDIOMETABOLIC RISK-FACTORS; VIGOROUS PHYSICAL-ACTIVITY; MENTAL-HEALTH
   PROBLEMS; SEDENTARY BEHAVIOR; ENVIRONMENTAL-FACTORS; OBESITY PREVENTION;
   OBJECTIVE MEASURES; CHILDREN; COHORT; MASS
AB BACKGROUND: In highly developed countries, childhood overweight and many overweight-related risk factors are negatively associated with socioeconomic status (SES).
   OBJECTIVE: The objective of this study is to investigate the longitudinal association between parental SES and childhood overweight, and to clarify whether familial, psychosocial or behavioural factors can explain any SES gradient.
   METHODS: The baseline and follow-up surveys of the identification and prevention of dietary and lifestyle induced health effects in children and infants (IDEFICS) study are used to investigate the longitudinal association between SES, familial, psychosocial and behavioural factors, and the prevalence of childhood overweight. A total of 5819 children (50.5% boys and 49.5% girls) were included.
   RESULTS: The risk for being overweight after 2 years at follow-up in children who were non-overweight at baseline increases with a lower SES. For children who were initially overweight, a lower parental SES carries a lower probability for a non-overweight weight status at follow-up. The effect of parental SES is only moderately attenuated by single familial, psychosocial or behavioural factors; however, it can be fully explained by their combined effect. Most influential of the investigated risk factors were feeding/eating practices, parental body mass index, physical activity behaviour and proportion of sedentary activity.
   CONCLUSION: Prevention strategies for childhood overweight should focus on actual behaviours, whereas acknowledging that these behaviours are more prevalent in lower SES families.
C1 [Bammann, K.] Univ Bremen, Inst Publ Hlth & Nursing Res ipp, Fac Human & Hlth Sci, FB 11,Grazer Str 2a, D-28359 Bremen, Germany.
   [Bammann, K.; Pischke, C.; Pigeot, I.] Leibniz Inst Prevent Res & Epidemiol BIPS, Bremen, Germany.
   [Gwozdz, W.; Reisch, L.] Copenhagen Business Sch, Dept Intercultural Commun & Management, Frederiksberg, Denmark.
   [Eiben, G.; Lissner, L.] Univ Gothenburg, Dept Publ Hlth & Community Med, Gothenburg, Sweden.
   [Fernandez-Alvira, J. M.; Moreno, L. A.] Univ Zaragoza, Dept Phys Med & Nursing, Growth Exercise Nutr & Dev GENUD Res Grp, Zaragoza, Spain.
   [De Henauw, S.] Univ Ghent, Dept Publ Hlth, Ghent, Belgium.
   [Pitsiladis, Y.] Univ Brighton, Ctr Sport & Exercise Sci & Med SESAME, Eastbourne, England.
   [Veidebaum, T.] Natl Inst Hlth Dev, Dept Chron Dis, Tallinn, Estonia.
   [Pigeot, I.] Univ Bremen, Fac Math & Comp Sci, Inst Stat, Bremen, Germany.
C3 University of Bremen; Leibniz Association; Leibniz Institute for
   Prevention Research & Epidemiology (BIPS); Copenhagen Business School;
   University of Gothenburg; University of Zaragoza; Ghent University;
   University of Brighton; National Institute for Health Development -
   Estonia; University of Bremen; Leibniz Association; Leibniz Institute
   for Prevention Research & Epidemiology (BIPS)
RP Bammann, K (corresponding author), Univ Bremen, Inst Publ Hlth & Nursing Res ipp, Fac Human & Hlth Sci, FB 11,Grazer Str 2a, D-28359 Bremen, Germany.
EM bammann@uni-bremen.de
RI Moreno, Luis/S-1780-2019; Reisch, Lucia/AAB-7589-2022; Pigeot,
   Iris/A-2722-2012; Fernández-Alvira, Juan/O-9665-2019; Yan,
   Xu/T-1427-2019; Reisch, Lucia/H-2074-2016
OI Pigeot, Iris/0000-0001-7483-0726; Bammann, Karin/0000-0002-5623-8160;
   Moreno Aznar, Luis A./0000-0003-0454-653X; Gwozdz,
   Wencke/0000-0001-7176-708X; Fernandez-Alvira, Juan
   Miguel/0000-0002-4145-5103; Pischke, Claudia/0000-0002-2256-8903;
   Pitsiladis, Yannis/0000-0001-6210-2449; Reisch,
   Lucia/0000-0002-5731-4209
FU European Community within the Sixth RTD Framework Programme [016181]
FX This work was done as part of the IDEFICS Study (www.idefics.eu). We
   gratefully acknowledge the financial support of the European Community
   within the Sixth RTD Framework Programme Contract Number 016181 (FOOD).
   We thank the IDEFICS children and their parents for their participation.
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NR 60
TC 13
Z9 15
U1 0
U2 24
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0307-0565
EI 1476-5497
J9 INT J OBESITY
JI Int. J. Obes.
PD JAN
PY 2017
VL 41
IS 1
BP 54
EP 60
DI 10.1038/ijo.2016.137
PG 7
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA EK7ZG
UT WOS:000394143100007
PM 27528253
DA 2025-06-11
ER

PT J
AU Li, YS
   Fujihara, H
   Fujisawa, K
   Kawai, K
AF Li, Yun-Shan
   Fujihara, Hiroald
   Fujisawa, Koichi
   Kawai, Kazuald
TI Effects of ergothioneine on oxidative DNA damage and immune response
   induced by circadian rhythm disturbance in mice
SO JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION
LA English
DT Article
DE ergothioneine; oxidative DNA damage; circadian rhythm; interleukin-6;
   8-hydroxy-2'- deoxyguanosine
ID METABOLIC SYNDROME; NIGHT; CANCER; CLOCK; RISK; PERFORMANCE; DISRUPTION;
   OBESITY; STRESS; SLEEP
AB Ergothioneine has antioxidant, anti-inflammatory, and cell-protective properties. Circadian rhythm disruption can lead to health issues, such as insomnia, mental illness, chronic diseases, and cancer. However, the impact of ergothioneine, as an antioxidant, on oxidative DNA damage and immune variations caused by circadian rhythm disruptions remains unclear. To investigate the effect of ergothioneine on oxidative DNA damage and immune responses caused by circadian rhythm disruption, 8-week-old mice were subjected to nighttime feeding and exercise restrictions for 14 days. Body weight, daytime running wheel activity, and anxiety-like behavior showed no significant differences between the night-restricted groups, regardless of ergothioneine administration. Serum interleukin-6 levels, 8hydroxy-2'-deoxyguanosine levels in urine and nuclear DNA of the liver, testes, lungs, and pancreas were significantly reduced in the night-restricted group receiving ergothioneine compared with that of the group without ergothioneine, with no significant differences observed when compared to the control group. Ergothioneine can mitigate immune function changes and oxidative DNA damage induced by circadian rhythm disruption caused by abnormal dietary timing in mice. However, it did not alleviate obesity or mental state dysregulation. These findings have important implications for improving nightshift workers health and developing therapies for diseases associated with circadian rhythm disturbances.
C1 [Li, Yun-Shan; Fujisawa, Koichi; Kawai, Kazuald] Univ Occupat & Environm Hlth, Dept Environm Oncol, Kitakyushu 8078555, Japan.
   [Fujihara, Hiroald] Univ Occupat & Environm Hlth, Dept Ergon, Kitakyushu 8078555, Japan.
   [Li, Yun-Shan] Univ Occupat & Environm Hlth, Ctr Stress Related Dis Control & Prevent, Kitakyushu 8078555, Japan.
C3 University of Occupational & Environmental Health - Japan; University of
   Occupational & Environmental Health - Japan; University of Occupational
   & Environmental Health - Japan
RP Li, YS (corresponding author), Univ Occupat & Environm Hlth, Dept Environm Oncol, Kitakyushu 8078555, Japan.; Li, YS (corresponding author), Univ Occupat & Environm Hlth, Ctr Stress Related Dis Control & Prevent, Kitakyushu 8078555, Japan.
EM liyunsha@med.uoeh-u.ac.jp
FU JSPS KAKENHI [JP21K06660]
FX <B>Acknowledgements</B> This work was supported by JSPS KAKENHI (grant
   number: JP21K06660) .
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NR 55
TC 0
Z9 0
U1 12
U2 12
PU JOURNAL CLINICAL BIOCHEMISTRY & NUTRITION
PI KYOTO
PA KYOTO PREFECTURAL UNIV MED, GRAD SCH MEDICAL SCIENCE, DEPT MOLECULAR
   GASTROENTEROLOGY & HEPATOLOGY, KYOTO, 602-8566, JAPAN
SN 0912-0009
EI 1880-5086
J9 J CLIN BIOCHEM NUTR
JI J. Clin. Biochem. Nutr.
PD MAR
PY 2025
VL 76
IS 2
BP 117
EP 124
DI 10.3164/jcbn.24-220
EA DEC 2024
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA Y9S6G
UT WOS:001382803100001
PM 40151407
OA gold
DA 2025-06-11
ER

PT J
AU Mansueto, P
   Seidita, A
   Vitale, G
   Gangemi, S
   Iaria, C
   Cascio, A
AF Mansueto, Pasquale
   Seidita, Aurelio
   Vitale, Giustina
   Gangemi, Sebastiano
   Iaria, Chiara
   Cascio, Antonio
TI Vitamin D Deficiency in HIV Infection: Not Only a Bone Disorder
SO BIOMED RESEARCH INTERNATIONAL
LA English
DT Review
ID HEPATITIS-C VIRUS; 25-HYDROXYVITAMIN D CONCENTRATIONS; ACTIVE
   ANTIRETROVIRAL THERAPY; WOMENS INTERAGENCY HIV; INTIMA-MEDIA THICKNESS;
   D INSUFFICIENCY; D SUPPLEMENTATION; CARDIOVASCULAR-DISEASE;
   INSULIN-RESISTANCE; IMMUNE ACTIVATION
AB Hypovitaminosis D is a worldwide disorder, with a high prevalence in the general population of both Western and developing countries. In HIV patients, several studies have linked vitamin D status with bone disease, neurocognitive impairment, depression, cardiovascular disease, high blood pressure, metabolic syndrome, type 2 diabetes mellitus, infections, autoimmune diseases like type 1 diabetesmellitus, and cancer. In this review, we focus on the most recent epidemiological and experimental data dealing with the relationship between vitamin D deficiency and HIV infection. We analysed the extent of the problem, pathogenic mechanisms, clinical implications, and potential benefits of vitamin D supplementation in HIV-infected subjects.
C1 [Mansueto, Pasquale; Seidita, Aurelio; Vitale, Giustina] Univ Palermo, Dept Internal Med & Biomed, I-90100 Palermo, Italy.
   [Gangemi, Sebastiano; Cascio, Antonio] Univ Messina, Dept Human Pathol, I-98125 Messina, Italy.
   [Gangemi, Sebastiano] IFC CNR, Messina Unit, I-98100 Messina, Italy.
   [Iaria, Chiara] Papardo Piemonte Hosp, Infectious Dis Unit, I-98125 Messina, Italy.
   [Cascio, Antonio] Univ Messina, AILMI ONLUS Italian Assoc Control Infect Dis, I-98125 Messina, Italy.
C3 University of Palermo; University of Messina; Consiglio Nazionale delle
   Ricerche (CNR); Istituto di Fisiologia Clinica (IFC-CNR); University of
   Messina
RP Cascio, A (corresponding author), Univ Messina, Dept Human Pathol, I-98125 Messina, Italy.
EM acascio@unime.it
RI gangemi, sebastiano/GLR-3109-2022; Mansueto, Pasquale/K-3458-2016;
   Seidita, Aurelio/IQT-5629-2023; Cascio, Antonio/K-5453-2016
OI Mansueto, Pasquale/0000-0002-0406-0583; Seidita,
   Aurelio/0000-0003-4080-2641; Cascio, Antonio/0000-0002-1992-1796; Iaria,
   Chiara/0000-0002-5477-9887; gangemi, sebastiano/0000-0001-7001-6532
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NR 98
TC 77
Z9 83
U1 1
U2 4
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2314-6133
EI 2314-6141
J9 BIOMED RES INT
JI Biomed Res. Int.
PY 2015
VL 2015
AR 735615
DI 10.1155/2015/735615
PG 18
WC Biotechnology & Applied Microbiology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Research & Experimental Medicine
GA CH8OA
UT WOS:000354294500001
PM 26000302
OA hybrid, Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Yang, TZ
   Yang, XZY
   Yu, LW
   Cottrell, RR
   Jiang, SH
AF Yang, Tingzhong
   Yang, Xiaozhao Y.
   Yu, Lingwei
   Cottrell, Randall R.
   Jiang, Shuhan
TI Individual and regional association between socioeconomic status and
   uncertainty stress, and life stress: a representative nationwide study
   of China
SO INTERNATIONAL JOURNAL FOR EQUITY IN HEALTH
LA English
DT Article
DE Socioeconomic status (SES); Life stress; Uncertainty stress; College
   students; Regional variance; China
ID METABOLIC SYNDROME; SOCIAL-STATUS; HEALTH; INEQUALITIES
AB Background: Many studies have examined the association between socioeconomic status (SES) and mental stress. Uncertainty stress is a prominent aspect of mental stress. Yet no research has ever empirically analyzed the impact of SES on uncertainty stress.
   Methods: Students were identified through a multistage survey sampling process including 50 universities. Each student participant completed the Global Health Professions Student Survey (GHPSS) on Tobacco Control in China. Regional variables were retrieved from the National Bureau of Statistics database. Both unadjusted and adjusted methods were considered in the analyses.
   Results: Among the 11,942 participants, severe uncertainty stress prevalence was 19.6%, while severe life stress prevalence was 8.6%. Multilevel logistic regression showed that most SES variables were associated with uncertainty stress. Students with "operation and commercial work" as mother's occupation and "rural or township" as family location exhibited a higher prevalence of severe uncertainty stress. Lower family income and original region gross domestic products (GDP) were also associated with higher severe uncertainty stress prevalence. However, only father's occupation was correlated with life stress.
   Conclusions: Based on the literature review, this is the first empirical study examining the impact of SES on uncertainty stress in China and elsewhere in the world. Our research underscores the importance of decreasing socioeconomic inequalities in controlling excessive uncertainty stress.
C1 [Yang, Tingzhong; Yu, Lingwei; Jiang, Shuhan] Zhejiang Univ, Sch Med, Dept Social Med, Ctr Tobacco Control Res, Hangzhou 310058, Zhejiang, Peoples R China.
   [Yang, Xiaozhao Y.] Murray State Univ, Dept Polit Sci & Sociol, Murray, KY 42701 USA.
   [Cottrell, Randall R.] Univ North Carolina Wilmington, Publ Hlth Studies Program, Wilmington, NC 28403 USA.
C3 Zhejiang University; Murray State University; University of North
   Carolina; University of North Carolina Wilmington
RP Yang, TZ (corresponding author), Zhejiang Univ, Sch Med, Dept Social Med, Ctr Tobacco Control Res, Hangzhou 310058, Zhejiang, Peoples R China.
EM Tingzhongyang@zju.edu.cn
RI Yang, Xiaozhao/AAH-5836-2019; jiang, shuhan/AAR-7378-2021
OI Yang, Xiaozhao/0000-0001-7354-7208
FU National Nature Science Foundation of China [71,490,733, 71473221];
   Global Bridges/IGLC [2014SC1]
FX This study was partly funded by the National Nature Science Foundation
   of China (Major Project, 71,490,733), the National Nature Science
   Foundation of China (71473221) and Global Bridges/IGLC, 2014SC1).
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NR 34
TC 34
Z9 38
U1 4
U2 41
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1475-9276
J9 INT J EQUITY HEALTH
JI Int. J. Equity Health
PD JUL 5
PY 2017
VL 16
AR 118
DI 10.1186/s12939-017-0618-7
PG 8
WC Public, Environmental & Occupational Health
WE Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA FA8GY
UT WOS:000405685400001
PM 28679409
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Wicks, SE
   Nguyen, TT
   Breaux, C
   Kruger, C
   Stadler, K
AF Wicks, Shawna E.
   Nguyen, Trang-Tiffany
   Breaux, Chelsea
   Kruger, Claudia
   Stadler, Krisztian
TI Diet-induced obesity and kidney disease - In search of a susceptible
   mouse model
SO BIOCHIMIE
LA English
DT Article
DE Obesity; Chronic kidney disease; Mouse models; High fat diet; Oxidative
   stress
ID HIGH-FAT DIET; INSULIN-RESISTANCE; DIABETIC-NEPHROPATHY; METABOLIC
   SYNDROME; OXIDATIVE STRESS; FUNCTIONAL-CHANGES; NITRIC-OXIDE; US ADULTS;
   PODOCYTE; MICE
AB Obesity and metabolic syndrome are independent risk factors for chronic kidney disease, even without diabetes or hyperglycemia.
   Here, we compare two mouse models that are susceptible to diet-induced obesity: the relatively renal injury resistant C57BL/6J strain and the DBA2/J strain which is more sensitive to renal injury. Our studies focused on characterizing the effects of high fat diet feeding on renal oxidative stress, albuminuria, fibrosis and podocyte loss/insulin resistance. While the C57BL/6J strain does not develop significant pathological changes in the kidney, at least on lard based diets within the time frame investigated, it does show increased renal iNOS and nitrotyrosine levels and elevated mitochondrial respiration which may be indicative of mitochondrial lipid overfueling. Restricting the high fat diet to decrease adiposity decreased the levels of cellular oxidative stress markers, indicating that adiposity-related proinflammatory changes such as increased iNOS levels may trigger similar responses in the kidney. Mitochondrial respiration remained higher, suggesting that eating excess lipids, despite normal adiposity may still lead to renal mitochondrial overfueling. In comparison, DBA/2J mice developed albuminuria on similar diets, signs of fibrosis, oxidative stress, early signs of podocyte loss (evaluated by the markers podocin and WT-1) and podocyte insulin resistance (unable to phosphorylate their glomerular Akt when insulin was given). To summarize, while the C57BL/6J strain is not particularly susceptible to renal disease, changes in its mitochondrial lipid handling combined with the easy availability of transgenic technology may be an advantage to design new knockout models related to mitochondrial lipid metabolism. The DBA/2J model could serve as a basis for studying podocyte insulin resistance and identifying early renal markers in obesity before more severe kidney disease develops. Based on our observations, we encourage further critical evaluation of mouse models for obesity related chronic kidney disease. (C) 2015 Elsevier B.V. and Societe Francaise de Biochimie et Biologie Moleculaire (SFBBM). All rights reserved.
C1 [Nguyen, Trang-Tiffany; Breaux, Chelsea; Kruger, Claudia; Stadler, Krisztian] Pennington Biomed Res Ctr, Oxidat Stress & Dis Lab, 6400 Perkins Rd, Baton Rouge, LA 70808 USA.
   [Wicks, Shawna E.] Pennington Biomed Res Ctr, Gene Nutrient Interact Lab, 6400 Perkins Rd, Baton Rouge, LA 70808 USA.
C3 Louisiana State University System; Louisiana State University;
   Pennington Biomedical Research Center; Louisiana State University
   System; Louisiana State University; Pennington Biomedical Research
   Center
RP Stadler, K (corresponding author), Pennington Biomed Res Ctr, Oxidat Stress & Dis Lab, 6400 Perkins Rd, Baton Rouge, LA 70808 USA.
EM krisztian.stadler@pbrc.edu
RI Stadler, Krisztian/N-1992-2017
FU NORC Pilot and Feasibility Award [NIH P30DK072476]; DiaComp Pilot and
   Feasibility Award [14GHSU1393]; NORC; COBRE [NIH P20-RR021945,
   P30-DK072476]; T32 Fellowship Award [T32 AT004094]
FX Research contributing to this manuscript from the Stadler lab was
   partially supported by a NORC Pilot and Feasibility Award (through NIH
   P30DK072476) and a DiaComp Pilot and Feasibility Award (14GHSU1393,
   K.S.). Confocal images were taken at the Pennington Cell Biology and
   Imaging Core, supported by the NORC and COBRE Grants (NIH P20-RR021945
   and P30-DK072476). S.W. was supported by a T32 Fellowship Award (T32
   AT004094).
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NR 39
TC 29
Z9 31
U1 2
U2 14
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0300-9084
EI 1638-6183
J9 BIOCHIMIE
JI Biochimie
PD MAY
PY 2016
VL 124
BP 65
EP 73
DI 10.1016/j.biochi.2015.08.001
PG 9
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA DK4UZ
UT WOS:000374917100008
PM 26248309
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Sattari, M
   Karimpour, A
   Taheri, MA
   Larijani, B
   Meshkani, R
   Tabatabaei-Malazy, O
   Panahi, G
AF Sattari, Mahboobe
   Karimpour, Amin
   Taheri, Maryam Akhavan
   Larijani, Bagher
   Meshkani, Reza
   Tabatabaei-Malazy, Ozra
   Panahi, Ghodratollah
TI Optimized Effects of Fisetin and Hydroxychloroquine on ER Stress and
   Autophagy in Nonalcoholic Fatty Pancreas Disease in Mice
SO JOURNAL OF DIABETES RESEARCH
LA English
DT Article
DE autophagy; ER stress; fatty pancreas; fisetin; hydroxychloroquine;
   metabolic syndrome
ID INSULIN-RESISTANCE; HEPATIC STEATOSIS; ECTOPIC FAT; BETA-CELL; IN-VIVO;
   DIET; CHLOROQUINE; INJURY; DRUG
AB Background: Fat accumulation in the pancreas, known as nonalcoholic fatty pancreatic disease (NAFPD), is associated with obesity and may lead to prediabetes and Type 2 diabetes. Reducing endoplasmic reticulum stress and enhancing autophagy could offer therapeutic benefits. This study examines the effects of fisetin (FSN) and hydroxychloroquine (HCQ) on NAFPD.Method: Forty-eight Male C57BL/6 J mice were assigned to a standard chow diet (SCD) or a high-fat diet (HFD) for 16 weeks. The HFD group was divided into five subgroups; each group contains eight mice: HFD, HFD + V (vehicle), HFD + FSN, HFD + HCQ, and HFD + FSN + HCQ. FSN was given daily at 80 mg/kg, and HCQ was injected IP at 50 mg/kg twice weekly for more 8 weeks. Insulin resistance was assessed through OGTT and HOMA-IR. Histological analysis of pancreatic tissue was conducted, and the protein and mRNA levels of molecules associated with ER stress and autophagy were assessed using PCR and immunoblotting techniques.Result: FSN and HCQ significantly reduced weight gain, pancreatic adipocyte accumulation, and insulin resistance caused by HFD in obese mice, with the combination of the two compounds producing even more pronounced effects. Additionally, the HFD increased the expression of UPR markers ATF4 and CHOP, a response that was further intensified by HCQ. In contrast, FSN attenuated the UPR by regulating GRP78 levels. Furthermore, the HFD resulted in a significant decrease in the LC3II/LC3I ratio and an accumulation of p62 protein due to reduced p-AMPK levels. Following treatment with FSN, these alterations were reversed, leading to decreased mTOR expression and increased levels of autophagy markers such as ATG5 and Beclin1.Conclusion: Our study reveals that FSN and HCQ effectively combat HFD-induced NAFPD, improving insulin sensitivity and addressing pancreatic fat deposition linked to metabolic syndrome. While HCQ may cause endoplasmic reticulum stress, FSN offers protective effects, supporting their combined use for better treatment outcomes.
C1 [Sattari, Mahboobe; Larijani, Bagher] Univ Tehran Med Sci, Endocrinol & Metab Clin Sci Inst, Endocrinol & Metab Res Ctr, Tehran, Iran.
   [Sattari, Mahboobe; Karimpour, Amin; Meshkani, Reza; Panahi, Ghodratollah] Univ Tehran Med Sci, Fac Med, Dept Clin Biochem, Tehran, Iran.
   [Karimpour, Amin] Univ Tehran Med Sci, Students Sci Res Ctr SSRC, Tehran, Iran.
   [Taheri, Maryam Akhavan] Kashan Univ Med Sci, Inst Basic Sci, Anat Sci Res Ctr, Kashan, Iran.
   [Tabatabaei-Malazy, Ozra] Univ Tehran Med Sci, Endocrinol & Metab Populat Sci Inst, Noncommunicable Dis Res Ctr, Tehran, Iran.
C3 Tehran University of Medical Sciences; Tehran University of Medical
   Sciences; Tehran University of Medical Sciences; Tehran University of
   Medical Sciences
RP Panahi, G (corresponding author), Univ Tehran Med Sci, Fac Med, Dept Clin Biochem, Tehran, Iran.; Tabatabaei-Malazy, O (corresponding author), Univ Tehran Med Sci, Endocrinol & Metab Populat Sci Inst, Noncommunicable Dis Res Ctr, Tehran, Iran.
EM tabatabaeiml@sina.tums.ac.ir; pshahriyar@gmail.com
RI Tabatabaei-Malazy, ozra/T-5561-2017; panahi, shahriyar/W-3772-2019;
   larijani, Bagher/ABE-3315-2020; Tabatabaei, ozra/E-3634-2013
OI Tabatabaei, ozra/0000-0003-0188-9721; Larijani,
   Bagher/0000-0001-5386-7597
FU Tehran University of Medical Sciences and Health Services
FX We express our gratitude to Tehrandarou Co. for supplying the
   hydroxychloroquine. We appreciate the Department of Clinical
   Biochemistry of Tehran University of Medical Science's staff and our
   colleagues for their invaluable assistance in conducting this study and
   for providing the best conditions, especially for the mice used in this
   research. We would like to acknowledge the assistance of an AI writing
   assistant in improving the quality of this manuscript.
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NR 56
TC 0
Z9 0
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2314-6745
EI 2314-6753
J9 J DIABETES RES
JI J. Diabetes Res.
PY 2025
VL 2025
IS 1
AR 2795127
DI 10.1155/jdr/2795127
PG 15
WC Endocrinology & Metabolism; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Research & Experimental Medicine
GA 1IQ0A
UT WOS:001465912300001
PM 40260275
OA gold
DA 2025-06-11
ER

PT J
AU Kanagasabai, T
   Alkhalaqi, K
   Churilla, JR
   Ardern, CI
AF Kanagasabai, Thirumagal
   Alkhalaqi, Khloud
   Churilla, James R.
   Ardern, Chris I.
TI The Association Between Metabolic Syndrome and Serum Concentrations of
   Micronutrients, Inflammation, and Oxidative Stress Outside of the
   Clinical Reference Ranges: A Cross-Sectional Study
SO METABOLIC SYNDROME AND RELATED DISORDERS
LA English
DT Article
DE micronutrients; inflammation; oxidative stress; serum biomarkers;
   carotenoids; vitamins
ID GAMMA-GLUTAMYL-TRANSFERASE; IRON-DEFICIENCY; ANTIOXIDANT STATUS;
   SEX-DIFFERENCES; US ADULTS; OBESITY; PREVALENCE; IMPACT; RISK
AB Background: Clinical reference ranges are often used to assess nutritional status, but whether having lower or higher than the current clinical reference range for micronutrients, inflammation, and oxidative stress is related to metabolic syndrome (MetS) is not known. Our objectives are to estimate the odds of having MetS outside of established clinical references, and to identify any effect modifications by sex for these relationships. Methods: Data from the 2005 to 2006 National Health and Nutrition Examination Survey were used (20 years; N=2049) with MetS defined utilizing the harmonized criteria from the Joint Interim Statement. The odds of having MetS in individuals with lower or higher than the clinical reference range for the serum concentrations of micronutrient antioxidants, inflammation, and oxidative stress were estimated following adjustments for age, sex, ethnicity, education, income, smoking, alcohol intake, recreational physical activity, and BMI. Results: Having lower than the clinical reference range for carotenoids and vitamin C [odds ratios (95% confidence interval): 1.37 (1.05-1.78) and 1.39 (1.01-1.90), respectively] was associated with significantly greater odds of MetS. By contrast, having higher than the clinical reference range for vitamins A and E, uric acid, and -glutamyl transferase (GGT) [2.10 (1.50-2.92), 2.36 (1.78-3.13), 2.65 (1.54-4.57), and 2.08 (1.61-2.69), respectively] was associated with higher odds of MetS, whereas higher levels of vitamins B12 were protective [0.64 (0.42-0.98]. Sex moderated these relationships for carotenoids, vitamin A, C, E, uric acid, C-reactive protein, and GGT. Conclusions: Lower carotenoids and vitamin C and higher vitamins A and E, uric acid, and oxidative stress were associated with a greater likelihood of MetS, whereas higher vitamin B12 was protective. Further research is necessary to replicate these findings in a prospective setting to confirm the importance of the overall and sex-specific findings.
C1 [Kanagasabai, Thirumagal; Ardern, Chris I.] York Univ, Sch Kinesiol & Hlth Sci, Toronto, ON, Canada.
   [Alkhalaqi, Khloud] MiSK Sch, Acad Dept, Riyadh, Saudi Arabia.
   [Churilla, James R.] Univ North Florida, Brooks Coll Hlth, Jacksonville, FL USA.
   [Kanagasabai, Thirumagal] McGill Univ, Dept Epidemiol Biostat & Occupat Hlth, 1130 Ave Pins, Montreal, PQ H3G 1A1, Canada.
C3 York University - Canada; State University System of Florida; University
   of North Florida; McGill University
RP Kanagasabai, T (corresponding author), McGill Univ, Dept Epidemiol Biostat & Occupat Hlth, 1130 Ave Pins, Montreal, PQ H3G 1A1, Canada.
EM tkanagas@yorku.ca
RI Churilla, James/AIB-2665-2022
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NR 45
TC 19
Z9 19
U1 0
U2 5
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-4196
EI 1557-8518
J9 METAB SYNDR RELAT D
JI Metab. Syndr. Relat. Disord.
PD FEB 1
PY 2019
VL 17
IS 1
BP 29
EP 36
DI 10.1089/met.2018.0080
EA OCT 2018
PG 8
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA HR8IS
UT WOS:000448561600001
PM 30372368
DA 2025-06-11
ER

PT J
AU Khan, MR
   Sheehan, PK
   Bazin, A
   Leonard, C
   Aleem, U
   Corrigan, L
   McDermott, R
AF Khan, M. Raheel
   Sheehan, Patrice Kearney
   Bazin, Ashley
   Leonard, Christine
   Aleem, Umair
   Corrigan, Lynda
   McDermott, Ray
TI Late side effects of testicular cancer and treatment: a comprehensive
   review
SO DISCOVER ONCOLOGY
LA English
DT Review
DE Testicular cancer; Cancer survivorship; Germ cell tumours; Chemotherapy
   late side-effect
ID GERM-CELL TUMORS; LYMPH-NODE DISSECTION; LONG-TERM SURVIVORS;
   CISPLATIN-BASED CHEMOTHERAPY; COLONY-STIMULATING FACTOR; RISK-FACTORS;
   PULMONARY-FUNCTION; COMBINATION CHEMOTHERAPY; CARDIOVASCULAR-DISEASE;
   ADJUVANT CHEMOTHERAPY
AB Testicular cancer is a rare solid organ tumour associated with high cure rates and young age at diagnosis, hence it has a sizeable cohort of survivors worldwide. As it is one of the earliest tumours to be cured, a lot of studies have highlighted the late side effects of cancer and its different treatment modalities including surgery, radiotherapy and chemotherapy. While we are trying to identify the population at higher risk of platinum based chemotherapy and reduce its exposure, cisplatin based regimes remain an important tool to cure testicular cancer. The list of late side effects include a number of fatal and morbid conditions including but not limited to the second malignant neoplasms, cardiovascular disease, hypogonadism, infertility, metabolic syndrome, chronic respiratory disease, renal insufficiency, hearing loss, peripheral neuropathy, infertility and psychological illnesses like stress and anxiety. These complications eventually result in compromised social and economic health as well as lower life expectancy compared to the normal population. This article provides a comprehensive review of the latest data regarding the late side effects in testicular cancer survivors. A review of these conditions can help us develop recommendations and guidelines to improve the morbidity and mortality in survivors of testicular cancer.
C1 [Khan, M. Raheel; Sheehan, Patrice Kearney; Bazin, Ashley; Leonard, Christine; Corrigan, Lynda; McDermott, Ray] Tallaght Univ Hosp, Dept Med Oncol, Tallaght, Dublin, Ireland.
   [McDermott, Ray] Univ Coll Dublin, Sch Med, Belfield D04 V1W8, Dublin, Ireland.
   [McDermott, Ray] St Vincents Univ Hosp, Dept Med Oncol, Elm Pk D04 YN26, Dublin, Ireland.
   [Aleem, Umair] Christie NHS Fdn Trust, Dept Med Oncol, 550 Wilmslow Rd, Manchester M20 4BX, England.
C3 University College Dublin; University College Dublin; Saint Vincent's
   University Hospital; Christie NHS Foundation Trust
RP Khan, MR (corresponding author), Tallaght Univ Hosp, Dept Med Oncol, Tallaght, Dublin, Ireland.
EM mraheelhashim@hotmail.com
RI McDermott, Sean/KYR-3316-2024
OI Khan, M Raheel/0009-0004-2828-5826
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NR 114
TC 0
Z9 0
U1 2
U2 3
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
EI 2730-6011
J9 DISCOV ONCOL
JI Discov. Oncol.
PD NOV 12
PY 2024
VL 15
IS 1
AR 646
DI 10.1007/s12672-024-01549-1
PG 13
WC Oncology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Endocrinology & Metabolism
GA L8C1V
UT WOS:001352938700002
PM 39532799
OA Green Accepted, gold
DA 2025-06-11
ER

PT J
AU Kim, OY
   Paik, JK
   Lee, JY
   Lee, SH
   Lee, JH
AF Kim, Oh Yoen
   Paik, Jean Kyung
   Lee, Ju Young
   Lee, Sang-Hyun
   Lee, Jong Ho
TI Follow-Ups of Metabolic, Inflammatory and Oxidative Stress Markers, and
   Brachial-Ankle Pulse Wave Velocity in Middle-Aged Subjects without
   Metabolic Syndrome
SO CLINICAL AND EXPERIMENTAL HYPERTENSION
LA English
DT Article
DE MetS; inflammatory; oxidative stress markers; brachial-ankle pulse wave
   velocity
ID BLOOD-CELL COUNT; CARDIOVASCULAR-DISEASE ENTERPRISES; ARTERIAL
   STIFFNESS; MAJOR SHAREHOLDERS; RISK-FACTORS; INTERLEUKIN-6;
   HYPERTENSION; CORONARY; DENSITY; EVENTS
AB This study investigates the association among metabolic risk factors, inflammatory and oxidative stress markers, and brachial-ankle pulse wave velocity (ba-PWV). We conducted a 3-year longitudinal, observational study of 288 middle-aged adults not meeting the criteria for metabolic syndrome (MetS) at the initial screening. We measured metabolic risk factors, inflammatory and oxidative stress markers, and ba-PWV. Within the 3-year study period, 15.6% (45 out of 288) of participants developed MetS. At the 3-year follow-up, patients were categorized as those with MetS (n = 45) and those without MetS (n = 243). Patients with MetS had significantly unfavorable initial measurements of baseline body mass index (BMI), waist circumference (WC), blood pressure (BP), triglyceride (TG), high-density lipoprotein (HDL)-cholesterol, glucose, insulin, homeostasis model assessment of insulin resistance (HOMA-IR) index, and ba-PWV. After 3 years, participants without MetS showed significant increases in WC, diastolic BP (DBP), total-and low-density lipoprotein (LDL)-cholesterol, malondialdehyde (MDA), oxidized-LDL (ox-LDL), and ba-PWV and a significant decrease in HDL-cholesterol and free fatty acids (FFA). Subjects who developed MetS showed significant increases in BMI, WC, BP, TG, glucose, interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), MDA, ox-LDL, and ba-PWV and a significant decrease in HDL-cholesterol. Changes in BMI, WC, BP, TG, HDL-cholesterol, glucose, HOMA-IR index, FFA, C-reactive protein (P = .022), IL-6 (P = .004), leukocyte count (P < .001), MDA (P = .002), ox-LDL (P = .015), and ba-PWV (P = .001) differed significantly between the two groups after adjustment for baseline values. Changes in ba-PWV were positively correlated with the changes in systolic and DBP, total-cholesterol, glucose, leukocyte count, and MDA. The age-related increase in arterial stiffness is greater in the presence of MetS with higher levels of inflammatory and oxidative stress markers.
C1 [Kim, Oh Yoen] Dong A Univ, Dept Food Sci & Nutr, Pusan, South Korea.
   [Paik, Jean Kyung] Eulji Univ, Dept Food & Nutr, Gyeonggi Do, South Korea.
   [Lee, Ju Young; Lee, Jong Ho] Yonsei Univ, Dept Food & Nutr, Natl Leading Res Lab Clin Nutrigenet Nutrigen, Seoul 120749, South Korea.
   [Lee, Sang-Hyun] Natl Hlth Insurance Corp Ilsan Hosp, Dept Family Practice, Goyang Si, South Korea.
   [Lee, Jong Ho] Yonsei Univ, Res Inst Sci Aging, Seoul 120749, South Korea.
C3 Dong A University; Eulji University; Yonsei University; Yonsei
   University
RP Lee, JH (corresponding author), Yonsei Univ, Coll Human Ecol, Dept Food & Nutr, 134 Shinchon Dong, Seoul 120749, South Korea.
EM jhleeb@yonsei.ac.kr
RI Lee, Sang-Hyun/ABR-3363-2022; Kim, Oh/AAA-6492-2022
FU Mid-Career Researcher Program through National Research Foundation,
   Ministry of Education, Science and Technology, Republic of Korea
   [2012-0005604, M10642120002-06N4212-00210, 2012M3A9C4048762,
   2012-0001851]; National Research Foundation of Korea [2012M3A9C4048762]
   Funding Source: Korea Institute of Science & Technology Information
   (KISTI), National Science & Technology Information Service (NTIS)
FX This work was supported by the Mid-Career Researcher Program through
   National Research Foundation, Ministry of Education, Science and
   Technology (2012-0005604, M10642120002-06N4212-00210, 2012M3A9C4048762
   and 2012-0001851), Republic of Korea.
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NR 32
TC 13
Z9 13
U1 0
U2 1
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1064-1963
EI 1525-6006
J9 CLIN EXP HYPERTENS
JI Clin. Exp. Hypertens.
PY 2013
VL 35
IS 5
BP 382
EP 388
DI 10.3109/10641963.2012.739232
PG 7
WC Pharmacology & Pharmacy; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Cardiovascular System & Cardiology
GA 180FM
UT WOS:000321579000012
PM 23148723
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Das, UN
AF Das, UN
TI Perinatal supplementation of long-chain polyunsaturated fatty acids,
   immune response and adult diseases
SO MEDICAL SCIENCE MONITOR
LA English
DT Article
DE long-chain polyunsaturated fatty acids; T cells; cytokines; atopy;
   asthma; adult diseases; perinatal programming; low-grade systemic
   inflammation; immune response
ID GAMMA-LINOLENIC ACID; INDUCED DIABETES-MELLITUS; FISH-OIL
   SUPPLEMENTATION; NECROSIS-FACTOR-ALPHA; C-REACTIVE PROTEIN; COD-LIVER
   OIL; RHEUMATOID-ARTHRITIS; INDUCED CYTOTOXICITY; CHILDHOOD LEUKEMIA;
   GENE-EXPRESSION
AB Both omega-6 and omega-3 long-chain polyunsaturated fatty acids (LCPUFAs) modulate T(H)1 and T(H)2 cell generation, their cytokine production, and cell proliferation and thus may serve as endogenous anti-inflammatory molecules. LCPUFAs suppress the production of tumor necrosis factor-alpha (TNF-alpha) (and so also of OX40, since it belongs to the family of TNFR) and the expression of Bcl-2, suggesting that these fatty acids have the ability to prevent/suppress autoimmune diseases. Human breast milk contains substantial amounts of both omega-3 and omega-6 fatty acids. This indicates that LCPUFAs present in human breast milk suppress the levels of OX40 and decrease the expression of Bcl-x(L) and Bcl-2 on exposure to self-antigens and thus, protects against the development of autoimmune diseases in later life. In view of this, I propose that supplementation of appropriate amounts of LCPUFAs during perinatal period protects against atopy, asthma, auto-immune diseases, type 1 and type 2 diabetes mellitus, hypertension, coronary heart disease, metabolic syndrome X, lymphomas, leukemias and other cancers, schizophrenia, depression and other adult diseases in which low-grade systemic inflammation plays a significant role. It is also likely that perinatal supplementation of LCPUFAs in adequate amounts modulates the expression of genes concerned with immune response, angiogenesis, central osmo/sodium and glucose sensors etc. This renders various tissues and organs including T cells and macrophages, endothelial cells, hypothalamic neurons, and various cardiovascular tissues to be able to counteract the pathological mechanisms that tend to induce various adult diseases by blunting the inflammatory responses in those who received adequate amounts of LCPUFAs during the perinatal period compared to those who did not.
C1 UND Life Sci, Walpole, ME 02081 USA.
RP UND Life Sci, 1083 Main St, Walpole, ME 02081 USA.
EM undurti@hotmail.com
RI Das, Undurti/A-7918-2009
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U2 3
PU INT SCIENTIFIC INFORMATION, INC
PI MELVILLE
PA 150 BROADHOLLOW RD, STE 114, MELVILLE, NY 11747 USA
SN 1643-3750
J9 MED SCI MONITOR
JI Med. Sci. Monitor
PD MAY
PY 2004
VL 10
IS 5
BP HY19
EP HY25
PG 7
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 867HN
UT WOS:000224833400001
PM 15114276
DA 2025-06-11
ER

PT J
AU Norris, E
   Hamer, M
   Stamatakis, E
AF Norris, Emma
   Hamer, Mark
   Stamatakis, Emmanuel
TI Active Video Games in Schools and Effects on Physical Activity and
   Health: A Systematic Review
SO JOURNAL OF PEDIATRICS
LA English
DT Review
ID CHILDHOOD OBESITY; SEDENTARY TIME; CARDIOMETABOLIC RISK;
   ENERGY-EXPENDITURE; MENTAL-HEALTH; AGED CHILDREN; EDUCATION; YOUTH;
   ADOLESCENTS; INTENSITY
AB Objective To assess the quality of evidence for the effects of school active video game (AVG) use on physical activity and health outcomes.
   Study design Online databases (ERIC, PsycINFO, PubMed, SPORTDiscus, and Web of Science) and gray literature were searched. Inclusion criteria were the use of AVGs in school settings as an intervention; assessment of at least 1 health or physical activity outcome; and comparison of outcomes with either a control group or comparison phase. Studies featuring AVGs within complex interventions were excluded. Study quality was assessed using the Effective Public Health Practice Project tool.
   Results Twenty-two reports were identified: 11 assessed physical activity outcomes only, 5 assessed motor skill outcomes only, and 6 assessed both physical activity and health outcomes. Nine out of 14 studies found greater physical activity in AVG sessions compared with controls; mostly assessed by objective measures in school time only. Motor skills were found to improve with AVGs vs controls in all studies but not compared with other motor skill interventions. Effects of AVGs on body composition were mixed. Study quality was low in 16 studies and moderate in the remaining 6, with insufficient detail given on blinding, participation rates, and confounding variables.
   Conclusions There is currently insufficient evidence to recommend AVGs as efficacious health interventions within schools. Higher quality AVG research utilizing randomized controlled trial designs, larger sample sizes, and validated activity measurements beyond the school day is needed.
C1 [Norris, Emma; Hamer, Mark] UCL, Dept Epidemiol & Publ Hlth, Mortimer St, London WC1E 7HB, England.
   [Hamer, Mark] Univ Loughborough, Natl Ctr Sport & Exercise Med, Sch Sport Exercise & Hlth Sci, Loughborough, Leics, England.
   [Stamatakis, Emmanuel] Univ Sydney, Sydney Med Sch, Sch Publ Hlth, Charles Perkins Ctr,Prevent Res Collaborat, Sydney, NSW 2006, Australia.
   [Stamatakis, Emmanuel] Univ Sydney, Fac Hlth Sci, Sydney, NSW 2006, Australia.
C3 University of London; University College London; Loughborough
   University; University of Sydney; University of Sydney
RP Norris, E (corresponding author), UCL, Dept Epidemiol & Publ Hlth, Mortimer St, London WC1E 7HB, England.
EM e.norris.11@ucl.ac.uk
RI Norris, Emma/B-1627-2014; Stamatakis, Emmanuel/C-4958-2009; Hamer,
   Mark/C-1602-2008
OI Hamer, Mark/0000-0002-8726-7992; Norris, Emma/0000-0002-9957-4025
FU University College London Crucible doctoral studentship; National Health
   and Medical Research Council through a Senior Research Fellowship
FX E.N. is funded by a University College London Crucible doctoral
   studentship. E.S. is funded by the National Health and Medical Research
   Council through a Senior Research Fellowship. The authors declare no
   conflicts of interest.
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NR 78
TC 41
Z9 46
U1 1
U2 54
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0022-3476
EI 1097-6833
J9 J PEDIATR-US
JI J. Pediatr.
PD MAY
PY 2016
VL 172
BP 40
EP +
DI 10.1016/j.jpeds.2016.02.001
PG 12
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Pediatrics
GA DK8WP
UT WOS:000375209600008
PM 26947570
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Seda, O
   Krenová, D
   Oliyarnyk, O
   Sedová, L
   Krupková, M
   Liska, F
   Chyliková, B
   Kazdová, L
   Kren, V
AF Seda, Ondrej
   Krenova, Drahomira
   Oliyarnyk, Olena
   Sedova, Lucie
   Krupkova, Michaela
   Liska, Frantisek
   Chylikova, Blanka
   Kazdova, Ludmila
   Kren, Vladimir
TI Heterozygous connexin 50 mutation affects metabolic syndrome attributes
   in spontaneously hypertensive rat
SO LIPIDS IN HEALTH AND DISEASE
LA English
DT Article
DE Connexin; Animal models; Lipoprotein; Oxidative stress; Metabolic
   syndrome
ID JUNCTION INTERCELLULAR COMMUNICATION; INDUCED INSULIN-RESISTANCE;
   GAP-JUNCTION; GLUCOSE-TOLERANCE; DEXAMETHASONE; CHOLESTEROL;
   HEMICHANNELS; SECRETION; MECHANISM; CATARACT
AB Background: Several members of connexin family of transmembrane proteins were previously implicated in distinct metabolic conditions. In this study we aimed to determine the effects of complete and heterozygous form of connexin50 gene (Gja8) mutation L7Q on metabolic profile and oxidative stress parameters in spontaneously hypertensive inbred rat strain (SHR).
   Methods: Adult, standard chow-fed male rats of SHR, heterozygous SHR-Dca+/- and SHR-Dca-/-coisogenic strains were used. At the age of 4 months, dexamethasone (2.6 mu g/ml) was administered in the drinking water for three days. The lipidemic profile (cholesterol and triacylglycerol concentration in 20 lipoprotein fractions, chylomicron, VLDL, LDL and HDL particle sizes) together with 33 cytokines and hormones in serum and several oxidative stress parameters in plasma, liver, kidney and heart were assessed.
   Results: SHR and SHR-Dca-/-rats had similar concentrations of triacylglycerols and cholesterol in all major lipoprotein fractions. The heterozygotes reached significantly highest levels of total (SHR-Dca+/- : 51.3 +/- 7.2 vs. SHR: 34.5 +/- 2.4 and SHR-Dca-/-: 34.4 +/- 2.5 mg/dl, p = 0.026), chylomicron and VLDL triacylglycerols. The heterozygotes showed significantly lowest values of HDL cholesterol (40.9 +/- 2.3 mg/dl) compared both to SHR (51.8 +/- 2.2 mg/dl) and SHR-Dca-/- (48.6 +/- 2.7 mg/dl). Total and LDL cholesterol in SHR-Dca+/- was lower compared to SHR. Glucose tolerance was improved and insulin concentrations were lowest in SHR-Dca-/- (1. 11 +/- 0.20 pg/ml) in comparison with both SHR (2.32 +/- 0.49 pg/ml) and SHR-Dca+/- (3.04 +/- 0.21 pg/ml). The heterozygous rats showed profile suggestive of increased oxidative stress as well as highest serum concentrations of several pro-inflammatory cytokines including interleukins 6, 12, 17, 18 and tumor necrosis factor alpha.
   Conclusions: Our results demonstrate that connexin50 mutation in heterozygous state affects significantly the lipid profile and the oxidative stress parameters in the spontaneously hypertensive rat strain.
C1 [Seda, Ondrej; Krenova, Drahomira; Sedova, Lucie; Krupkova, Michaela; Liska, Frantisek; Chylikova, Blanka; Kren, Vladimir] Charles Univ Prague, Fac Med 1, Inst Biol & Med Genet, Albertov 4, Prague 12800 2, Czech Republic.
   [Seda, Ondrej; Sedova, Lucie] Acad Sci Czech Republ, Lab Rat Models Metab Disorders, Div BIOCEV, Inst Mol Genet, Videnska 1083, Prague 14220 4, Czech Republic.
   [Oliyarnyk, Olena; Kazdova, Ludmila] Ctr Med Expt, Inst Clin & Expt Med, Videnska 1958-9, Prague 14021 4, Czech Republic.
C3 Charles University Prague; Czech Academy of Sciences; Institute of
   Molecular Genetics of the Czech Academy of Sciences; Institute for
   Clinical & Experimental Medicine (IKEM)
RP Seda, O (corresponding author), Charles Univ Prague, Fac Med 1, Inst Biol & Med Genet, Albertov 4, Prague 12800 2, Czech Republic.; Seda, O (corresponding author), Acad Sci Czech Republ, Lab Rat Models Metab Disorders, Div BIOCEV, Inst Mol Genet, Videnska 1083, Prague 14220 4, Czech Republic.
EM ondrej.seda@lf1.cuni.cz
RI Oliyarnyk, Olena/Q-6380-2019; Seda, Ondrej/A-2058-2008; Sedova,
   Lucie/D-1089-2017; Chylikova, Blanka/D-2976-2017; Krupkova,
   Michaela/L-2373-2017; Liska, Frantisek/N-9192-2017
OI Seda, Ondrej/0000-0001-8498-5895; Sedova, Lucie/0000-0003-3783-2946;
   Oliyarnyk, Olena/0000-0002-4912-6187; Chylikova,
   Blanka/0000-0002-3439-1850; Krupkova, Michaela/0000-0002-9371-2511;
   Liska, Frantisek/0000-0002-9588-806X
FU Czech Science Foundation [GACR P301/12/0777]; Ministry of Education,
   Youth and Sports of the Czech Republic [LK11217]; Charles University in
   Prague [PRVOUK-P25/LF1/2, UNCE 204022]
FX This work was supported by Czech Science Foundation Project GACR
   P301/12/0777, Project LK11217 from the Ministry of Education, Youth and
   Sports of the Czech Republic and Charles University in Prague
   [PRVOUK-P25/LF1/2, UNCE 204022].
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NR 43
TC 2
Z9 2
U1 0
U2 8
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1476-511X
J9 LIPIDS HEALTH DIS
JI Lipids Health Dis.
PD NOV 21
PY 2016
VL 15
AR 199
DI 10.1186/s12944-016-0376-3
PG 9
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA ED3TA
UT WOS:000388770200001
PM 27871290
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Rangel-Huerta, OD
   Aguilera, CM
   Martin, MV
   Soto, MJ
   Rico, MC
   Vallejo, F
   Tomas-Barberan, F
   Perez-De-La-Cruz, AJ
   Gil, A
   Mesa, MD
AF Rangel-Huerta, Oscar D.
   Aguilera, Concepcion M.
   Martin, Maria V.
   Soto, Maria J.
   Rico, Maria C.
   Vallejo, Fernando
   Tomas-Barberan, Francisco
   Perez-de-la-Cruz, Antonio J.
   Gil, Angel
   Mesa, Maria D.
TI Normal or High Polyphenol Concentration in Orange Juice Affects
   Antioxidant Activity, Blood Pressure, and Body Weight in Obese or
   Overweight Adults
SO JOURNAL OF NUTRITION
LA English
DT Article
DE antioxidants; flavanones; obesity; orange juice; oxidative stress
ID OXIDATIVE STRESS; GLUCOSYL HESPERIDIN; CITRUS FLAVONOIDS; VITAMIN-E;
   NARINGIN; CHOLESTEROL; BIOMARKERS; HESPERETIN; SUPPLEMENTATION;
   METABOLITES
AB Background: The consumption of orange juice may lead to reduced oxidative stress and may enhance the antioxidant defense system.
   Objective: The aim was to evaluate the effects of the intake of orange juice containing either normal (NPJ) or high (HPJ) concentrations of polyphenols (299 and 745 mg/d, respectively) on the antioxidant defense system, oxidative stress biomarkers, and clinical signs of metabolic syndrome in 100 nonsmoking subjects who were either overweight or obese.
   Methods: A randomized, double-blind crossover study was conducted over two 12-wk periods with a 7-wk washout period. The effects on enzymatic and nonenzymatic blood antioxidant defense systems, urinary and plasma oxidative stress biomarkers, and clinical signs of metabolic syndrome were evaluated before and after an intervention with both of the orange juices. Paired t tests and linear mixed-effects models were used to evaluate the effects of juice, time, and interactions.
   Results: The intake of either NPJ or HPJ led to a decrease in urinary 8-hydroxy-2'-deoxyguanosine (NPJ: 935 +/- 134 to 298 +/- 19 ng/mg creatinine; HPJ: 749 +/- 84 to 285 +/- 17 ng/mg creatinine), 8-iso-prostaglandin F2 alpha (NPJ: 437 +/- 68 to 156 +/- 14 ng/mg creatinine; HPJ: 347 +/- 43 to 154 +/- 13 ng/mg creatinine), erythrocyte catalase, and glutathione reductase activities. A decrease was also observed in body mass index, waist circumference, and leptin (all P < 0.051) The NPJ intervention decreased systolic and diastolic blood pressures (systolic blood pressure: 128 +/- 1 to 124 +/- 2 mm Hg; diastolic blood pressure: 79 +/- 1 to 76 +/- 1 mm Hg), whereas the HPJ intervention increased erythrocyte superoxide dismutase (SOD) activity (17.7 +/- 1.5 to 23.1 +/- 1.7 U/mg hemoglobin).
   Conclusions: Our results show that the consumption of either NPJ or HPJ protected against DNA damage and lipid peroxidation, modified several antioxidant enzymes, and reduced body weight in overweight or obese nonsmoking adults. Only blood pressure and SOD activity were influenced differently by the different flavanone supplementations.
C1 [Rangel-Huerta, Oscar D.; Aguilera, Concepcion M.; Martin, Maria V.; Rico, Maria C.; Gil, Angel; Mesa, Maria D.] Univ Granada, Ctr Biomed Res, Inst Nutr & Food Technol Jose Mataix, Dept Biochem & Mol Biol 2, Granada, Spain.
   [Soto, Maria J.] Ctr Studies Sensory Impairment Aging & Metab, Guatemala City, Guatemala.
   [Vallejo, Fernando; Tomas-Barberan, Francisco] Ctr Soil Sci & Appl Biol Segura Superior Council, Dept Food Sci & Technol, Res Grp Qual Safety & Bioact Plant Foods, Murcia, Spain.
   [Perez-de-la-Cruz, Antonio J.] Univ Hosp Virgen Nieves, Granada, Spain.
C3 University of Granada; Consejo Superior de Investigaciones Cientificas
   (CSIC); CSIC - Centro de Edafologia y Biologia Aplicada del Segura
   (CEBAS); Hospital Universitario Virgen de las Nieves
RP Gil, A (corresponding author), Univ Granada, Ctr Biomed Res, Inst Nutr & Food Technol Jose Mataix, Dept Biochem & Mol Biol 2, Granada, Spain.
EM agil@ugr.es
RI Gil, Angel/L-2275-2014; Rico Prados/G-4601-2016; Soto Mendez, Maria
   Jose/U-1639-2017; Mesa, Maria/M-3523-2014; Tomas-Barberan,
   Francisco/D-6686-2011; Aguilera, Concepcion/M-1663-2014; Rangel Huerta,
   Oscar Daniel/I-4019-2015
OI Gil, Angel/0000-0001-7663-0939; Rico Prados/0000-0001-7742-5742; Soto
   Mendez, Maria Jose/0000-0002-1012-4715; Mesa, Maria/0000-0003-4079-6464;
   Tomas-Barberan, Francisco/0000-0002-0790-1739; Aguilera,
   Concepcion/0000-0002-1451-4788; Rangel Huerta, Oscar
   Daniel/0000-0001-8585-0108; Vallejo, Fernando/0000-0003-3343-6479
FU University of Granada Enterprise General Foundation [3345]; Coca-Cola
   Europe [3345]
FX Supported by research contract 3345 between the University of Granada
   Enterprise General Foundation and Coca-Cola Europe.
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NR 51
TC 105
Z9 108
U1 0
U2 33
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0022-3166
EI 1541-6100
J9 J NUTR
JI J. Nutr.
PD AUG
PY 2015
VL 145
IS 8
BP 1808
EP 1816
DI 10.3945/jn.115.213660
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA CO3DT
UT WOS:000359037500018
PM 26136593
OA Bronze
DA 2025-06-11
ER

PT J
AU Aguglia, A
   Signorelli, MS
   Albert, U
   Maina, G
AF Aguglia, Andrea
   Signorelli, Maria Salvina
   Albert, Umberto
   Maina, Giuseppe
TI The Impact of General Medical Conditions in Obsessive-Compulsive
   Disorder
SO PSYCHIATRY INVESTIGATION
LA English
DT Article
DE Obsessive-compulsive disorder; General medical condition; Cardiovascular
   disease; Duration of untreated illness; Medical illness
ID METABOLIC SYNDROME; ANXIETY DISORDERS; BIPOLAR DISORDER; UNTREATED
   ILLNESS; WEIGHT-GAIN; FOLLOW-UP; DEPRESSION; PREVALENCE; RISK; SYMPTOMS
AB Objective The co-occurrence of general medical conditions (GMCs) and major psychiatric disorders is well documented. The aim of this study was to assess the prevalence of GMCs in patients with a primary diagnosis of obsessive-compulsive disorder (OCD) and, secondly, to investigate which clinical variables are associated with the presence of a GMC.
   Methods Subjects with a primary diagnosis of OCD were included. Socio-demographic and clinical characteristics were collected. GMCs were classified using the ICD-10 and grouped according to the Cumulative Illness Rating Scale (CIRS) in: cardiac, vascular, hematopoietic, respiratory, ear/nose/throat, upper and lower gastrointestinal, hepatic, renal, genitourinary, musculoskeletal, neurologic, endocrine/metabolic. The association between the presence of GMCs and demographic/clinical variables of OCD was investigated.
   Results A total of 162 patients with OCD were included. 78 (48.1%) patients had at least one comorbid GMC. Most frequent GMCs were endocrine/metabolic diseases (25.9%), followed by upper/lower gastrointestinal (20.5%) and cardio-vascular diseases (13.6%). The presence of a GMC was significantly associated with female gender, older age, duration of untreated illness (DUI), and absence of physical activity.
   Conclusion Patients with OCD have high rates of comorbid GMCs. A longer DUI is associated with having at least one GMCs; this might be due to the long-lasting adoption of unhealthy lifestyles, not counterbalanced by appropriate treatment and psychoeducation.
C1 [Aguglia, Andrea; Albert, Umberto; Maina, Giuseppe] Univ Turin, San Luigi Gonzaga Hosp, Rita Levi Montalcini Dept Neurosci, Psychiat Unit, Reg Gonzole 10, I-10043 Turin, Italy.
   [Signorelli, Maria Salvina] Univ Catania, AOU Policlin Hosp, Dept Clin & Expt Med, Catania, Italy.
C3 Azienda Ospedaliero-Universitaria San Luigi Gonzaga; University of
   Turin; University of Catania
RP Aguglia, A (corresponding author), Univ Turin, San Luigi Gonzaga Hosp, Rita Levi Montalcini Dept Neurosci, Psychiat Unit, Reg Gonzole 10, I-10043 Turin, Italy.
EM andrea.aguglia@unito.it
RI Maina, Giuseppe/AAC-7158-2022; Signorelli, Maria Salvina/E-6155-2010;
   Salvina, Maria/E-6155-2010
OI Aguglia, Andrea/0000-0002-2003-2101; Signorelli, Maria
   Salvina/0000-0001-5835-4176; Salvina, Maria/0000-0002-6941-9454
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NR 56
TC 33
Z9 40
U1 0
U2 3
PU KOREAN NEUROPSYCHIATRIC ASSOC
PI SEOUL
PA RN 522, G-FIVE CENTRAL PLAZA 1685-8 SEOCHO 4-DONG, SEOCHO-GU, SEOUL,
   137-882, SOUTH KOREA
SN 1738-3684
EI 1976-3026
J9 PSYCHIAT INVEST
JI Psychiatry Investig.
PD MAR
PY 2018
VL 15
IS 3
BP 246
EP 253
DI 10.30773/pi.2017.06.17.2
PG 8
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA FZ6BQ
UT WOS:000427682300004
PM 29475243
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Steen, VM
   Nepal, C
   Ersland, KM
   Holdhus, R
   Nævdal, M
   Ratvik, SM
   Skrede, S
   Håvik, B
AF Steen, Vidar M.
   Nepal, Chirag
   Ersland, Kari M.
   Holdhus, Rita
   Naevdal, Marianne
   Ratvik, Siri M.
   Skrede, Silje
   Havik, Bjarte
TI Neuropsychological Deficits in Mice Depleted of the Schizophrenia
   Susceptibility Gene CSMD1
SO PLOS ONE
LA English
DT Article
ID DRUG-NAIVE; RNA; ASSOCIATION; POPULATION; MOLECULES; KINASE
AB Recent meta-analyses of schizophrenia genome-wide association studies (GWASs) have identified the CUB and SUSHI multiple domains 1 (CSMD1) gene as a statistically strong risk factor. CSMD1 is a complement control-related protein suggested to inhibit the classical complement pathway, being expressed in developing neurons. However, expression of CSMD1 is largely uncharacterized and relevance for behavioral phenotypes is not previously demonstrated. Here, we assess neuropsychological behaviors of a Csmd1 knockout (KO) mouse in a selection of standard behavioral tests. Deregulation of neuropsychological responses were observed in both the open field and the elevated plus maze tests, in which KO mice spent 55% and 33% less time than WT littermate mice in open areas, respectively. Altered behaviors were also observed in tail suspension and to higher acoustic stimuli, for which Csmd1 KO mice showed helplessness and moderate increase in startle amplitude, respectively. Furthermore, Csmd1 KO mice also displayed increased weight-gain and glucose tolerance, similar to a major phenotype of the metabolic syndrome that also has been associated to the human CSMD1 locus. Consistent with a role in the control of behaviors, Csmd1 was found highly expressed in the central nervous system (CNS), and with some expression in visceral fat and ovary, under tissue-specific control by a novel promoter-associated lncRNA. In summary, disruption of Csmd1 induces behaviors reminiscent of blunted emotional responses, anxiety and depression. These observations suggest an influence of the CSMD1 schizophrenia susceptibility gene on psychopathology and endophenotypes of the negative symptom spectra.
C1 [Steen, Vidar M.; Nepal, Chirag; Ersland, Kari M.; Holdhus, Rita; Naevdal, Marianne; Ratvik, Siri M.; Skrede, Silje; Havik, Bjarte] Univ Bergen, Dr E Martens Res Grp Biol Psychiat, Bergen, Norway.
   [Steen, Vidar M.; Nepal, Chirag; Ersland, Kari M.; Holdhus, Rita; Naevdal, Marianne; Ratvik, Siri M.; Skrede, Silje; Havik, Bjarte] Univ Bergen, KG Jebsen Ctr Psychosis Res, Dept Clin Sci, Bergen, Norway.
   [Steen, Vidar M.; Nepal, Chirag; Ersland, Kari M.; Holdhus, Rita; Naevdal, Marianne; Ratvik, Siri M.; Skrede, Silje; Havik, Bjarte] Haukeland Hosp, Ctr Med Genet & Mol Med, N-5021 Bergen, Norway.
C3 University of Bergen; University of Bergen; University of Bergen;
   Haukeland University Hospital
RP Håvik, B (corresponding author), Univ Bergen, Dr E Martens Res Grp Biol Psychiat, Bergen, Norway.
EM bjarte.haavik@uib.no
RI Nepal, Chirag/K-5866-2019; Skrede, Silje/AAA-4453-2019
OI Ersland, Kari Merete/0000-0003-3674-4151; Nepal,
   Chirag/0000-0001-8402-3805
FU Research Council of Norway (Psykisk Helse Grant) [186001]; Research
   Council of Norway (FUGE Grant) [151904, 183327]; Bergen Medical Research
   Foundation (BMFS); Kristian Gerhard Jebsen Foundation; Helse Vest RHF;
   Dr. Einar Martens Fund
FX This study was supported by the Research Council of Norway (Psykisk
   Helse Grant No. 186001 and the FUGE Grant Nos. 151904 and 183327),
   Bergen Medical Research Foundation (BMFS), The Kristian Gerhard Jebsen
   Foundation, Helse Vest RHF and Dr. Einar Martens Fund. The funders had
   no role in study design, data collection and analysis, decision to
   publish, or preparation of the manuscript.
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NR 47
TC 58
Z9 68
U1 0
U2 65
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD NOV 14
PY 2013
VL 8
IS 11
AR e79501
DI 10.1371/journal.pone.0079501
PG 10
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 254DJ
UT WOS:000327143800084
PM 24244513
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Ginis, KAM
   van der Ploeg, HP
   Foster, C
   Lai, B
   McBride, CB
   Ng, K
   Pratt, M
   Shirazipour, CH
   Smith, B
   Vásquez, PM
   Heath, GW
AF Ginis, Kathleen A. Martin
   van der Ploeg, Hidde P.
   Foster, Charlie
   Lai, Byron
   McBride, Christopher B.
   Ng, Kwok
   Pratt, Michael
   Shirazipour, Celina H.
   Smith, Brett
   Vasquez, Priscilla M.
   Heath, Gregory W.
TI Participation of people living with disabilities in physical activity: a
   global perspective
SO LANCET
LA English
DT Review
ID ACTIVITY QUESTIONNAIRE; INTELLECTUAL DISABILITIES; CEREBRAL-PALSY;
   SHORT-FORM; CHILDREN; INTERVENTIONS; INDIVIDUALS; HEALTH; METAANALYSIS;
   ADULTS
AB Approximately 1.5 billion people worldwide live with a physical, mental, sensory, or intellectual disability, about 80% of which are in low-income and middle-income countries. This Series paper provides a global overview of the prevalence, benefits, and promotion policies for physical activity for people living with disabilities (PLWD). PLWD are 16-62% less likely to meet physical activity guidelines and are at higher risk of serious health problems related to inactivity than people without disabilities. Meta-analyses have shown that physical activity has beneficial effects on cardiovascular fitness (average standardised mean difference [SMD] 0.69 [95% CI 0.31-1.01]), musculoskeletal fitness (0.59 [0.31-0.87]), cardiometabolic risk factors (0.39 [0.04-0.75]), and brain and mental health outcomes (0.47 [0.21-0.73]). These meta-analyses also show that health benefits can be achieved even with less than 150 min of physical activity per week, and suggest that some physical activity is better than none. Meta-analyses of interventions to increase physical activity for PLWD have reported effect sizes ranging from SMD 0.29 (95% CI 0.17-0.41, k=10) to 1.00 (0.46-1.53, k=10). There is increasing awareness among policy makers of the needs of PLWD for full participation in physical activity. Physical activity action plans worldwide must be adequately resourced, monitored, and enforced to truly advance the fundamental rights of PLWD to fully participate in physical activity.
C1 [Ginis, Kathleen A. Martin] Univ British Columbia, Fac Hlth & Social Dev, Sch Hlth & Exercise Sci, Dept Med,Fac Med, Kelowna, BC, Canada.
   [Ginis, Kathleen A. Martin] Univ British Columbia, Fac Hlth & Social Dev, Sch Hlth & Exercise Sci, Ctr Chron Dis Prevent & Management,Fac Med, Kelowna, BC, Canada.
   [Ginis, Kathleen A. Martin] Univ British Columbia, Fac Hlth & Social Dev, Sch Hlth & Exercise Sci, Int Collaborat Repair Discoveries,Fac Med, Kelowna, BC, Canada.
   [Ginis, Kathleen A. Martin] Univ British Columbia, Reichwald Hlth Sci Ctr, Kelowna, BC, Canada.
   [van der Ploeg, Hidde P.] Vrije Univ Amsterdam, Amsterdam UMC, Dept Publ & Occupat Hlth, Amsterdam, Netherlands.
   [van der Ploeg, Hidde P.] Vrije Univ Amsterdam, Amsterdam UMC, Amsterdam Publ Hlth Res Inst, Amsterdam, Netherlands.
   [van der Ploeg, Hidde P.] Univ Sydney, Sydney Sch Publ Hlth, Sydney, NSW, Australia.
   [Foster, Charlie] Univ Bristol, Sch Policy Studies, Ctr Exercise Nutr & Hlth Sci, Bristol, Avon, England.
   [Lai, Byron] Univ Alabama Birmingham, Sch Med, Div Pediat Rehabil Med, Birmingham, AL USA.
   [McBride, Christopher B.] Spinal Cord Injury British Columbia, Vancouver, BC, Canada.
   [Ng, Kwok] Univ Eastern Finland, Sch Educ Sci & Psychol, Joensuu, Finland.
   [Ng, Kwok] Univ Limerick, Dept Phys Educ & Sport Sci, Limerick, Ireland.
   [Smith, Brett] Univ Durham, Sch Sport & Exercise Sci, Durham, England.
   [Pratt, Michael] Univ Calif San Diego, Inst Publ Hlth, San Diego, CA 92103 USA.
   [Pratt, Michael] Univ Calif San Diego, Herbert Wertheim Sch Publ Hlth & Human Longev Sci, San Diego, CA 92103 USA.
   [Vasquez, Priscilla M.] Univ Calif San Diego, Dept Family Med & Publ Hlth, San Diego, CA 92103 USA.
   [Shirazipour, Celina H.] Cedars Sinai Med Ctr, Res Ctr Hlth Equ, Los Angeles, CA 90048 USA.
   [Shirazipour, Celina H.] Univ Calif Los Angeles, Dept Med, Los Angeles, CA 90024 USA.
   [Heath, Gregory W.] Univ Tennessee, Dept Hlth & Human Performance, Chattanooga, TN USA.
C3 University of British Columbia; University of British Columbia;
   University of British Columbia; University of British Columbia; Vrije
   Universiteit Amsterdam; University of Amsterdam; University of
   Amsterdam; Vrije Universiteit Amsterdam; University of Sydney;
   University of Bristol; University of Alabama System; University of
   Alabama Birmingham; University of Eastern Finland; University of
   Limerick; Durham University; Public Health Institute; University of
   California System; University of California San Diego; University of
   California System; University of California San Diego; University of
   California System; University of California San Diego; Cedars Sinai
   Medical Center; University of California System; University of
   California Los Angeles; University of Tennessee System; University of
   Tennessee at Chattanooga
RP Ginis, KAM (corresponding author), Univ British Columbia, Fac Med, Kelowna, BC V1V 1V7, Canada.
EM kathleen_martin.ginis@ubc.ca
RI MARTIN GINIS, KATHLEEN/KFS-1807-2024; van der Ploeg,
   Hidde/ABD-6402-2021; Ng, Kwok/K-6648-2013
OI MARTIN GINIS, KATHLEEN/0000-0002-7076-3594; Smith,
   Brett/0000-0001-7137-2889; Ng, Kwok/0000-0002-5461-7706; van der Ploeg,
   Hidde/0000-0002-3719-5249
FU US National Institutes of Health [NIH 3R15GM131315-01A1S1]
FX We gratefully acknowledge research and administrative support from
   Gabriel Dix, Sarah Lawrason, Zachary North, Ritu Sharma, and Adrienne
   Sinden. KAMG holds the Reichwald Family Southern Medical Program Chair
   in Preventive Medicine. GWH is in receipt of a US National Institutes of
   Health grant that is unrelated to this manuscript (NIH
   3R15GM131315-01A1S1).
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NR 112
TC 272
Z9 287
U1 19
U2 137
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0140-6736
EI 1474-547X
J9 LANCET
JI Lancet
PD JUL 31
PY 2021
VL 398
IS 10298
BP 443
EP 455
DI 10.1016/S0140-6736(21)01164-8
EA JUL 2021
PG 13
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA TS1BS
UT WOS:000679392600026
PM 34302764
OA Green Published, Green Accepted, Bronze
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Siskind, D
   Bull, C
   Suetani, S
   Warren, N
   Suraev, A
   Mcgregor, I
   Kisely, S
   De Monte, V
   Trott, M
   Shine, M
   Moudgil, V
   Robinson, G
   Parker, S
   Krishnaiah, R
   Stedman, T
   Drummond, A
   Medland, S
   Iyer, R
   Baker, A
AF Siskind, Dan
   Bull, Claudia
   Suetani, Shuichi
   Warren, Nicola
   Suraev, Anastasia
   Mcgregor, Iain
   Kisely, Steve
   De Monte, Veronica
   Trott, Mike
   Shine, Manju
   Moudgil, Vikas
   Robinson, Gail
   Parker, Stephen
   Krishnaiah, Ravikumar
   Stedman, Terry
   Drummond, Allan
   Medland, Sarah
   Iyer, Ravi
   Baker, Andrea
TI Protocol for Cancloz: multicentre randomised, placebo-controlled,
   double-blind, parallel-group adaptive trial of cannabidiol for
   clozapine-resistant schizophrenia
SO BJPSYCH OPEN
LA English
DT Article
DE Schizophrenia; cannabidiol; clozapine; treatment-resistant
   schizophrenia; randomised controlled trial
ID GUIDELINES; COGNITION; SCALE
AB Background Although clozapine is the most effective antipsychotic for people with treatment-resistant schizophrenia (TRS), only 40% of people with TRS respond, and there is limited evidence for augmentation agents. Cannabidiol (CBD) reduces positive symptoms in individuals with schizophrenia, but no trials have specifically examined its efficacy in those with clozapine-resistant schizophrenia. Aims To examine the clinical efficacy of CBD augmentation in people with clozapine-resistant schizophrenia. Method This is a 12-week randomised, placebo-controlled, double-blind, parallel-group trial (registration number: ACTRN12622001112752). We will recruit 88 individuals with clozapine-resistant schizophrenia, randomised (1:1) to 1000 mg daily CBD versus placebo. Eligible individuals will be aged between 18 and 64 years, fulfil DSM-IV criteria for schizophrenia or schizoaffective disorder, have a total PANSS (Positive and Negative Syndrome Scale) score >= 60, have received oral clozapine for at least 18 weeks and have a clozapine level of >350 ng/mL. Interim analyses will be conducted at 25, 50 and 75% recruitment; these will also provide an opportunity to reallocate participants dependent on conditional power. The primary endpoint will be the difference in PANSS positive scores at the end of week 12. Secondary endpoints include depression, anxiety, sleep, quality of life, alcohol consumption, change in weight and metabolic syndrome components, and neurocognitive measures, as well as safety and tolerability. Discussion Novel treatments for clozapine-resistant schizophrenia are urgently needed. If found to be effective, CBD may have a role as a novel and safe adjunct to clozapine.
C1 [Siskind, Dan; Bull, Claudia; Warren, Nicola; Kisely, Steve; Trott, Mike; Parker, Stephen] Univ Queensland, Fac Med, Woolloongabba, Australia.
   [Siskind, Dan; Warren, Nicola; Kisely, Steve; De Monte, Veronica; Shine, Manju] Metro South Addict & Mental Hlth Serv, Woolloongabba, Australia.
   [Siskind, Dan; Bull, Claudia; Suetani, Shuichi; Warren, Nicola; Trott, Mike; Baker, Andrea] Queensland Ctr Mental Hlth Res, Wacol, Australia.
   [Siskind, Dan; Suetani, Shuichi] Univ Queensland, Queensland Brain Inst, Brisbane, Australia.
   [Suetani, Shuichi] Inst Urban Indigenous Hlth, Windsor, Australia.
   [Suetani, Shuichi; Parker, Stephen] Griffith Univ, Sch Med & Dent, Southport, Australia.
   [Suraev, Anastasia; Mcgregor, Iain] Univ Sydney, Lambert Initiat Cannabinoid Therapeut, Sydney, Australia.
   [Moudgil, Vikas; Parker, Stephen] Royal Brisbane Womens Hosp, Metro North Mental Hlth, Herston, Australia.
   [Robinson, Gail] Prince Charles Hosp, Metro North Mental Hlth, Chermside, Australia.
   [Krishnaiah, Ravikumar] Gold Coast Univ Hosp, Community Mental Hlth, Southport, Australia.
   [Stedman, Terry] West Moreton Div Mental Hlth & Specialised Serv, Wacol, Australia.
   [Drummond, Allan] Goodna Community Mental Hlth, Goodna, Australia.
   [Drummond, Allan] Integrated Mental Hlth Ctr, Ipswich, Australia.
   [Medland, Sarah] QIMR Berghofer Med Res Inst, Herston, Australia.
   [Iyer, Ravi] MAGNET Mental Hlth Australia Gen Clin Trials Netwo, Geelong, Australia.
   [Iyer, Ravi] Swinburne Univ Technol, Hawthorn, Australia.
C3 University of Queensland; Queensland Centre for Mental Health Research;
   University of Queensland; Griffith University; Griffith University -
   Gold Coast Campus; University of Sydney; Royal Brisbane & Women's
   Hospital; Prince Charles Hospital; Gold Coast University Hospital; QIMR
   Berghofer Medical Research Institute; Swinburne University of Technology
RP Siskind, D (corresponding author), Univ Queensland, Fac Med, Woolloongabba, Australia.; Siskind, D (corresponding author), Metro South Addict & Mental Hlth Serv, Woolloongabba, Australia.; Siskind, D (corresponding author), Queensland Ctr Mental Hlth Res, Wacol, Australia.; Siskind, D (corresponding author), Univ Queensland, Queensland Brain Inst, Brisbane, Australia.
EM d.siskind@uq.edu.au
RI Medland, Sarah/HRD-4930-2023; Parler, Stephen/D-7830-2013; McGregor,
   Iain/E-4463-2014; Robinson, Gail/C-2978-2011; Suraev,
   Anastasia/AAJ-3524-2021; Bull, Claudia/JRW-5850-2023; Warren,
   Nicola/O-8355-2018; Kisely, Steve/B-4680-2012; Trott, Mike/GWR-1913-2022
OI Warren, Nicola/0000-0002-0805-1182; Bull, Claudia/0000-0003-4064-652X;
   Kisely, Steve/0000-0003-4021-2924; Trott, Mike/0000-0001-5978-3407;
   Suetani, Shuichi/0000-0002-2487-5691
FU Princess Alexandra Hospital Foundation [RSS_2021_020]; Lambert
   Initiative for Cannabinoid Therapeutics at the University of Sydney
FX This work was supported by the Princess Alexandra Hospital Foundation
   (D.S. (RSS_2021_020)) and the Lambert Initiative for Cannabinoid
   Therapeutics at the University of Sydney. The manufacturer of the CBD is
   not involved in the design of the study. The CBD and placebo were
   supplied for this trial by the Lambert Initiative for Cannabinoid
   Therapeutics at the University of Sydney.
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NR 43
TC 0
Z9 0
U1 0
U2 0
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 2056-4724
J9 BJPSYCH OPEN
JI BJPsych Open
PD OCT 3
PY 2024
VL 10
IS 5
AR e156
DI 10.1192/bjo.2024.748
PG 7
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA I0E1U
UT WOS:001327067000001
PM 39359160
OA gold
DA 2025-06-11
ER

PT J
AU Chistiakov, DA
   Orekhov, AN
   Bobryshev, YV
AF Chistiakov, Dimitry A.
   Orekhov, Alexander N.
   Bobryshev, Yuri V.
TI Endothelial Barrier and Its Abnormalities in Cardiovascular Disease
SO FRONTIERS IN PHYSIOLOGY
LA English
DT Review
DE endothelium; endothelial barrier; cell-to-cell junctions; endothelial
   intercellular junctions; cardiovascular disease
AB Endothelial cells (ECs) form a unique barrier between the vascular lumen and the vascular wall. In addition, the endothelium is highly metabolically active. In cardiovascular disease such as atherosclerosis and hypertension, normal endothelial function could be severely disturbed leading to endothelial dysfunction that then could progress to complete and irreversible loss of EC functionality and contribute to entire vascular dysfunction. Proatherogenic stimuli such as diabetes, dyslipidemia, and oxidative stress could initiate endothelial dysfunction and in turn vascular dysfunction and lead to the development of atherosclerotic arterial disease, a background for multiple cardiovascular disorders including coronary artery disease, acute coronary syndrome, stroke, and thrombosis. Intercellular junctions between ECs mediate the barrier function. Proinflammatory stimuli destabilize the junctions causing the disruption of the endothelial barrier and increased junctional permeability. This facilitates transendothelial migration of immune cells to the arterial intima and induction of vascular inflammation. Proatherogenic stimuli attack endothelial microtubule function that is regulated by acetylation of tubulin, an essential microtubular constituent. Chemical modification of tubulin caused by cardiometabolic risk factors and oxidative stress leads to reorganization of endothelial microtubules. These changes destabilize vascular integrity and increase permeability, which finally results in increasing cardiovascular risk.
C1 [Chistiakov, Dimitry A.] Res Ctr Childrens Hlth, Inst Pediat, Dept Mol Genet Diagnost & Cell Biol, Div Lab Med, Moscow, Russia.
   [Orekhov, Alexander N.] Russian Acad Sci, Inst Gen Pathol & Pathophysiol, Lab Angiopathol, Moscow, Russia.
   [Orekhov, Alexander N.] Moscow MV Lomonosov State Univ, Biol Fac, Dept Biophys, Moscow, Russia.
   [Orekhov, Alexander N.] Skolkovo Innovat Ctr, Inst Atherosclerosis Res, Moscow, Russia.
   [Bobryshev, Yuri V.] Univ New South Wales, Sch Med Sci, Fac Med, Sydney, NSW, Australia.
   [Bobryshev, Yuri V.] Univ Western Sydney, Sch Med, Campbelltown, NSW, Australia.
C3 Russian Academy of Medical Sciences; Institute of General Pathology &
   Pathophysiology, RAMS; Russian Academy of Sciences; Lomonosov Moscow
   State University; University of New South Wales Sydney; Western Sydney
   University
RP Bobryshev, YV (corresponding author), Univ New South Wales, Sch Med Sci, Fac Med, Sydney, NSW, Australia.; Bobryshev, YV (corresponding author), Univ Western Sydney, Sch Med, Campbelltown, NSW, Australia.
EM y.bobryshev@unsw.edu.au
RI Bobryshev, Yuri/J-2838-2013
FU Russian Scientific Foundation [14-15-00112]
FX This work was supported by a grant from the Russian Scientific
   Foundation (grant 14-15-00112).
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NR 118
TC 182
Z9 204
U1 2
U2 16
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-042X
J9 FRONT PHYSIOL
JI Front. Physiol.
PD DEC 9
PY 2015
VL 6
AR 365
DI 10.3389/fphys.2015.00365
PG 11
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA VF7OS
UT WOS:000443518100001
PM 26696899
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Herrero-Beaumont, G
   Castro-Dominguez, F
   Migliore, A
   Naredo, E
   Largo, R
   Reginster, JY
AF Herrero-Beaumont, Gabriel
   Castro-Dominguez, Francisco
   Migliore, Alberto
   Naredo, Esperanza
   Largo, Raquel
   Reginster, Jean-Yves
TI Systemic osteoarthritis: the difficulty of categorically naming a
   continuous condition
SO AGING CLINICAL AND EXPERIMENTAL RESEARCH
LA English
DT Article
DE Osteoarthritis; Systemic; Chronic inflammation; Metabolic syndrome;
   Personalized treatment
ID KNEE OSTEOARTHRITIS; ADIPOSE-TISSUE; OBESITY; DISEASE
AB Osteoarthritis (OA) is a disease with systemic implications that go beyond joint problems. Its pathogenic mechanisms involve a variety of systemic conditions that contribute to joint damage. These include metabolic dysfunction, chronic low-grade inflammation, neuroplastic pain, and the influence of the central nervous system in the development of neuropathic pain. Besides, OA can negatively affect other aspects of health, such as quality of life, reduced physical activity, social isolation, depression, and anxiety. OA can be considered a complex system in which pathological interactions involve not only obesity and metabolic dysfunction, but also fragility syndrome, sarcopenia, neurological complications, and systemic energy redistribution. Complex systems are composed of multiple interacting and dynamic parts and exhibit emergent properties that cannot be fully explained by examining their individual components. Chronic low-grade inflammation is characteristic of OA, occurring both in the affected joint, and systemically, mainly due to adipose tissue inflammation in obese patients. Obesity is a key factor in the progression of OA, so primary treatment should focus on its control, while maintaining muscle health. The chronic inflammation could lead to changes in energy distribution among the affected joint tissues. Therefore, OA should be approached as a systemic disease, considering individual patient factors, such as genetics, inflammatory response, and lifestyle. Medical care should be more holistic and personalized. Consideration of a name change, such as "systemic OA", could help to move away from the perception of a disease focused only on the joints.
C1 [Herrero-Beaumont, Gabriel; Naredo, Esperanza; Largo, Raquel] IIS Fdn Jimenez Diaz UAM, Rheumatol Dept, Bone & Joint Res Unit, Madrid, Spain.
   [Castro-Dominguez, Francisco] Teknon Med Ctr, Rheumatol Dept, Quironsalud Grp, Barcelona, Spain.
   [Migliore, Alberto] San Pietro Fatebenefratelli Hosp, Rheumatol Unit, Rome, Italy.
   [Reginster, Jean-Yves] Univ Liege, WHO Collaborating Ctr Epidemiol Musculoskeletal Hl, Div Publ Hlth Epidemiol & Hlth Econ, Liege, Belgium.
C3 Fundacion Jimenez Diaz; quironsalud Group; University of Liege
RP Herrero-Beaumont, G (corresponding author), IIS Fdn Jimenez Diaz UAM, Rheumatol Dept, Bone & Joint Res Unit, Madrid, Spain.
EM gherrero@fjd.es
RI Reginster, Jean-Yves/AGC-6097-2022; Largo, Raquel/B-2949-2009
OI Largo, Raquel/0000-0001-6525-2944; Herrero-Beaumont,
   Gabriel/0000-0002-3241-991X; Castro-Dominguez,
   Francisco/0000-0003-1238-4200
FU Instituto de Salud Carlos III [PI20/00349, PI22/00352]; European Union
FX This study was supported by research grants from the Instituto de Salud
   Carlos III (PI20/00349; PI22/00352), co-funded by the European Union.
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NR 34
TC 8
Z9 8
U1 2
U2 7
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1594-0667
EI 1720-8319
J9 AGING CLIN EXP RES
JI Aging Clin. Exp. Res.
PD FEB 20
PY 2024
VL 36
IS 1
AR 45
DI 10.1007/s40520-024-02714-w
PG 5
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA IV0R0
UT WOS:001168998800001
PM 38376694
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Thakur, B
   Alvarado, L
   Dodoo, C
   Salazar, R
   Espay, AJ
   Dwivedi, AK
AF Thakur, Bhaskar
   Alvarado, Luis
   Dodoo, Christopher
   Salazar, Ricardo
   Espay, Alberto J.
   Dwivedi, Alok Kumar
TI Ethnic Differences Between Hispanics and Non-Hispanic Whites in
   Neuropsychiatric Symptoms Predict Conversion to Mild Cognitive
   Impairment
SO JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY
LA English
DT Article
DE neuropsychiatric symptoms; mild cognitive impairment; variable cluster
   analysis; psychomotor apathy; affective mood; physical behavior
ID ALZHEIMERS-DISEASE; MEXICAN-AMERICANS; BEHAVIORAL SYMPTOMS; METABOLIC
   SYNDROME; RISK-FACTORS; DEMENTIA; POPULATION; PREVALENCE; DIAGNOSIS;
   MANIFESTATIONS
AB The aim of the study is to ascertain the neuropsychiatric symptoms (NPS) subtypes significantly influencing progression to mild cognitive impairment (MCI) by ethnicity. In this retrospective cohort study, we included 386 cognitively normal individuals participating in the longitudinal Texas Alzheimer's Research and Care Consortium between February 2007 and August 2014. The primary outcome was time to incident MCI. Data driven NPS subtypes at baseline were identified and the effects of these subtypes on the outcome were obtained for Hispanic and non-Hispanic ethnic cohorts and summarized with a hazard ratio (HR). Three NPS subtypes were identified and internally validated: psychomotor apathy factor (including agitation, irritability, apathy), affective mood factor (including depression, anxiety), and physical behavior factor (including nighttime behavior, eating/appetite disturbances). In adjusted analysis, a psychomotor apathy score of NPS was the best predictor for MCI (HR = 2.19, p = 0.037) among non-Hispanics whereas physical behavior score was the most predictive of MCI (HR = 2.55, p = 0.029) among Hispanics. A high score of affective mood factor also tended to increase the risk of MCI (HR = 2.09, p = 0.06) in Hispanics. Progression from normal cognition to MCI was differentially predicted by NPS subtypes in Hispanics and non-Hispanic whites. These data may inform the allocation of efforts for monitoring individuals at-risk of MCI.
C1 [Thakur, Bhaskar; Dwivedi, Alok Kumar] Texas Tech Univ, Hlth Sci Ctr El Paso, Div Biostat & Epidemiol, Dept Mol & Translat Med,Paul L Foster Sch Med, El Paso, TX USA.
   [Alvarado, Luis; Dodoo, Christopher; Dwivedi, Alok Kumar] Texas Tech Univ, Hlth Sci Ctr El Paso, Biostat & Epidemiol Consulting Lab, Paul L Foster Sch Med, El Paso, TX USA.
   [Dodoo, Christopher; Salazar, Ricardo] Texas Tech Univ, Paul L Foster Sch Med, Memory Disorder & Geriatr Neuropsychiat Clin, Div Geriatr Psychiat,Dept Psychiat,Hlth Sci Ctr E, El Paso, TX USA.
   [Espay, Alberto J.] Univ Cincinnati, Dept Neurol & Rehabil Med, James J & Joan A Gardner Family Ctr Parkinsons Di, Cincinnati, OH 45221 USA.
C3 Texas Tech University System; Texas Tech University; Texas Tech
   University Health Sciences Center El Paso; Texas Tech University System;
   Texas Tech University; Texas Tech University Health Sciences Center El
   Paso; Texas Tech University System; Texas Tech University; University
   System of Ohio; University of Cincinnati
RP Dwivedi, AK (corresponding author), Texas Tech Univ, Hlth Sci Ctr El Paso TTUHSC EP, Paul L Foster Sch Med, Div Biostat & Epidemiol,Dept Mol & Translat Med, El Paso, TX 79905 USA.
EM alok.dwivedi@ttuhsc.edu
RI Dodoo, Christpher/AAE-9313-2019; Salazar, Ricardo/AAG-7883-2021; Espay,
   Alberto/AAC-4255-2020; Thakur, Bhaskar/AAE-9281-2019
OI Thakur, Bhaskar/0000-0001-6869-8968; Salazar,
   Ricardo/0000-0003-0608-2193; Dwivedi, Alok/0000-0003-4574-1761; Dodoo,
   Christopher/0000-0001-6269-1757
FU Darrell K Royal Texas Alzheimer's Initiative
FX The author(s) have not directly received any funding for this research
   study. However, this study was made possible by funding provided to the
   Texas Alzheimer's Research and Care Consortium by the Darrell K Royal
   Texas Alzheimer's Initiative, directed by the Texas Council on
   Alzheimer's Disease and Related Disorders.
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NR 60
TC 15
Z9 15
U1 0
U2 2
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0891-9887
EI 1552-5708
J9 J GERIATR PSYCH NEUR
JI J. Geriatr. Psychiatry Neurol.
PD NOV
PY 2021
VL 34
IS 6
SI SI
BP 622
EP 631
AR 0891988720957087
DI 10.1177/0891988720957087
EA SEP 2020
PG 10
WC Geriatrics & Gerontology; Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Neurosciences & Neurology; Psychiatry
GA WZ4KM
UT WOS:000568526300001
PM 32909879
DA 2025-06-11
ER

PT J
AU Albini, A
   La Vecchia, C
   Magnoni, F
   Garrone, O
   Morelli, D
   Janssens, JP
   Maskens, A
   Rennert, G
   Galimberti, V
   Corso, G
AF Albini, Adriana
   La Vecchia, Carlo
   Magnoni, Francesca
   Garrone, Ornella
   Morelli, Danilo
   Janssens, Jaak Ph.
   Maskens, Alain
   Rennert, Gad
   Galimberti, Viviana
   Corso, Giovanni
TI Physical activity and exercise health benefits: cancer prevention,
   interception, and survival
SO EUROPEAN JOURNAL OF CANCER PREVENTION
LA English
DT Article
DE cancer; exercise; physical activity; prevention; therapy
ID BREAST-CANCER; LIFE-STYLE; CARDIORESPIRATORY FITNESS; INDEPENDENT
   PREDICTOR; EUROPEAN ASSOCIATION; SEDENTARY BEHAVIOR; ESC GUIDELINES;
   HEART-FAILURE; IMMUNE-SYSTEM; DOSE-RESPONSE
AB Physical activity (PA) has an established role in the promotion of health and fitness and the prevention of disease. Expected overall benefits include reduction of all-cause morbidity and death, weight control, improved quality of life, improved bone health and decreased falls of elderly subjects, , deeper cognition, and reduced risk of depression, anxiety, and sleeplessness. Currently, PA is a mainstay in the management of cardiovascular diseases, metabolic syndrome, diabetes, and bone health. Recently, the perception of its role in primary and secondary prevention, interception, and treatment of cancer, however, is also gaining importance. Regular walking, the simplest type of PA, is associated with reduced all-cause and cardiovascular disease mortality, and a role in cancer prevention is of increasing interest. Furthermore, PA improves the quality of life of cancer patients, attenuating side effects of chemotherapy, decreasing sarcopenia, increasing fitness, and inhibiting the recurrence and progression of some cancer types. It promotes emotional and psychological benefits in patients, inducing positive changes. While mechanisms, effective levels and useful amount of PA practice are well established in cardiology, they are yet to be fully determined in oncology. Nevertheless, PA is recommended to reduce cancer risk in the general population, and it has been introduced in programs for the prevention of second cancers. In perspective, it will help as integrative therapy in cancer patients and for cancer survivors. The number of beneficial effects in the cancer continuum is highlighted in this review.
C1 [Albini, Adriana] Ist Ricovero & Cura Carattere Sci IRCCS, European Inst Oncol IEO, Via Giuseppe Ripamonti 435, Bari 20141, Italy.
   [La Vecchia, Carlo] Univ Milan, Dept Clin Sci & Community Hlth, Milan, Italy.
   [Magnoni, Francesca; Galimberti, Viviana; Corso, Giovanni] European Inst Oncol IEO, Ist Ricovero & Cura Carattere Sci IRCCS, Div Breast Surg, Bari, Italy.
   [Garrone, Ornella] Fdn IRCCS CaGranda Osped Maggiore Policlin, Dept Med Oncol, Milan, Italy.
   [Morelli, Danilo] Ist Ricovero & Cura Carattere Sci IRCCS Multimed, Milan, Italy.
   [Janssens, Jaak Ph.; Maskens, Alain] European Canc Prevent Org ECP, Milan, Italy.
   [Rennert, Gad] Carmel Hosp, Haifa, Israel.
   [Rennert, Gad] Technion Fac Med, Haifa, Israel.
   [Corso, Giovanni] Univ Milan, Dept Oncol & Hematooncol, Milan, Italy.
C3 IRCCS European Institute of Oncology (IEO); University of Milan; IRCCS
   European Institute of Oncology (IEO); IRCCS Ca Granda Ospedale Maggiore
   Policlinico; Clalit Health Services; Carmel Medical Center; Technion
   Israel Institute of Technology; Rappaport Faculty of Medicine;
   University of Milan
RP Albini, A (corresponding author), Ist Ricovero & Cura Carattere Sci IRCCS, European Inst Oncol IEO, Via Giuseppe Ripamonti 435, Bari 20141, Italy.
EM adriana.albini@ieo.it
RI Romero, Atocha/AAS-2862-2021; Magnoni, Francesca/E-3147-2019; Garrone,
   Ornella/HHS-9402-2022; Corso, Giovanni/AAN-5976-2020
FU Italian Ministry of Health Ricerca Corrente; European Institute of
   Oncology; IRCCS MultiMedica, Italy
FX The authors thank Francesca Albini and Paola Corradino for their
   collaboration and William Russel Edu for helping with the bibliography.
   Editorial assistance was provided by Aashni Shah and Laura Brogelli, PhD
   (Polistudium srl, Milan, Italy); graphic assistance was provided by
   Massimiliano Pianta (Polistudium srl, Milan, Italy).This study was
   sustained through the 'Umberto Veronesi' Foundation project: 'Massive
   CDH1 genetic screening in the so-called hereditary breast-gastric cancer
   syndrome' to G.C. The work was also supported by the Italian Ministry of
   Health Ricerca Corrente to IRCCS IEO, European Institute of Oncology,
   and IRCCS MultiMedica, Italy.
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NR 153
TC 8
Z9 8
U1 11
U2 11
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0959-8278
EI 1473-5709
J9 EUR J CANCER PREV
JI Eur. J. Cancer Prev.
PD JAN
PY 2025
VL 34
IS 1
BP 24
EP 39
DI 10.1097/CEJ.0000000000000898
PG 16
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA O8Q1M
UT WOS:001373697400009
PM 38920329
DA 2025-06-11
ER

PT J
AU Pompili, M
   Venturini, P
   Lamis, DA
   Giordano, G
   Serafini, G
   Murri, MB
   Amore, M
   Girardi, P
AF Pompili, Maurizio
   Venturini, Paola
   Lamis, Dorian A.
   Giordano, Gloria
   Serafini, Gianluca
   Murri, Martino Belvederi
   Amore, Mario
   Girardi, Paolo
TI Suicide in Stroke Survivors: Epidemiology and Prevention
SO DRUGS & AGING
LA English
DT Review
ID CARDIOVASCULAR RISK-FACTORS; LATE-LIFE DEPRESSION; QUALITY-OF-LIFE;
   POSTSTROKE DEPRESSION; ANTIDEPRESSANT TREATMENT; BIPOLAR-DISORDER;
   DOUBLE-BLIND; METABOLIC SYNDROME; MAJOR DEPRESSION; MEDICAL ILLNESS
AB Stroke is a dramatic event and is associated with potentially severe consequences, including disability, mortality, and social costs. Stroke may occur at any age; however, most strokes occur in individuals aged 65 years and older. Previous research has found that stroke increases suicide risk, especially among women and younger patients. The aim of the current review is to investigate the relationship between suicide and stroke in order to determine which stroke patients are at elevated risk for suicide. Moreover, we review the literature in order to provide pharmacological treatment strategies for stroke patients at high risk of suicide. We performed a careful search to identify articles and book chapters focused on this issue, selecting only English-language articles published from 1990 to 2014 that addressed the issue of suicide after stroke and its pharmacological management. We found 12 clinical trials that explored the relationship between stroke and suicidal ideation and/or suicidal plans and 11 investigating suicide as the cause of death after stroke. We identified stroke as a significant risk factor for both suicide and suicidal ideation, especially among younger adult depressed patients in all articles, providing further support for the association between post-stroke and suicidality. Suicide risk is particularly high in the first 5 years following stroke. Depression, previous mood disorder, prior history of stroke, and cognitive impairment were found to be the most important risk factors for suicide. Selective serotonin reuptake inhibitors (SSRIs) represent the treatment of choice for stroke survivors with suicide risk, and studies in rats have suggested that carbolithium is a promising treatment in these patients. Early identification and treatment of post-stroke depression may significantly reduce suicide risk in stroke patients.
C1 [Pompili, Maurizio; Venturini, Paola; Giordano, Gloria; Girardi, Paolo] Univ Roma La Sapienza, Dept Neurosci Mental Hlth & Sensory Organs, Suicide Prevent Ctr, St Andrea Hosp, I-00189 Rome, Italy.
   [Lamis, Dorian A.] Emory Univ, Sch Med, Dept Psychiat & Behav Sci, Atlanta, GA USA.
   [Serafini, Gianluca; Murri, Martino Belvederi; Amore, Mario] Univ Genoa, Sect Psychiat, Dept Neurosci Rehabi ,Ophthalmol Gene Maternal &, Genoa, Italy.
C3 Sapienza University Rome; Azienda Ospedaliera Sant'Andrea; Emory
   University; University of Genoa
RP Pompili, M (corresponding author), Univ Roma La Sapienza, Dept Neurosci Mental Hlth & Sensory Organs, Suicide Prevent Ctr, St Andrea Hosp, 1035-1039 Via Grottarossa, I-00189 Rome, Italy.
EM maurizio.pompili@uniroma1.it
RI Lamis, Dorian/AAM-3651-2020; Pompili, Maurizio/AAC-1011-2019; Altamura,
   Mario/IQS-2773-2023; Belvederi Murri, Martino/G-8781-2011; Serafini,
   Gianluca/K-6603-2016
OI Belvederi Murri, Martino/0000-0002-7262-3528; Serafini,
   Gianluca/0000-0002-6631-856X; Lamis, Dorian/0000-0001-5405-0239;
   Pompili, Maurizio/0000-0003-1886-4977
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NR 110
TC 77
Z9 82
U1 2
U2 25
PU ADIS INT LTD
PI NORTHCOTE
PA 5 THE WAREHOUSE WAY, NORTHCOTE 0627, AUCKLAND, NEW ZEALAND
SN 1170-229X
EI 1179-1969
J9 DRUG AGING
JI Drugs Aging
PD JAN
PY 2015
VL 32
IS 1
BP 21
EP 29
DI 10.1007/s40266-014-0233-x
PG 9
WC Geriatrics & Gerontology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Pharmacology & Pharmacy
GA AY8NN
UT WOS:000347810600003
PM 25491561
DA 2025-06-11
ER

PT J
AU Owczarczyk-Saczonek, A
   Krajewska-Wlodarczyk, M
   Kruszewska, A
   Banasiak, L
   Placek, W
   Maksymowicz, W
   Wojtkiewicz, J
AF Owczarczyk-Saczonek, Agnieszka
   Krajewska-Wlodarczyk, Magdalena
   Kruszewska, Anna
   Banasiak, Lukasz
   Placek, Waldemar
   Maksymowicz, Wojciech
   Wojtkiewicz, Joanna
TI Therapeutic Potential of Stem Cells in Follicle Regeneration
SO STEM CELLS INTERNATIONAL
LA English
DT Review
ID DERMAL PAPILLA CELLS; HAIR FOLLICLE; CONDITIONED MEDIA;
   WNT/BETA-CATENIN; ADIPOSE-TISSUE; UMBILICAL-CORD; BONE-MARROW; TGF-BETA;
   ACTIVATION; GROWTH
AB Alopecia is caused by a variety of factors which affect the hair cycle and decrease stem cell activity and hair follicle regeneration capability. This process causes lower self-acceptance, which may result in depression and anxiety. However, an early onset of androgenic alopecia is associated with an increased incidence of the metabolic syndrome and an increased risk of the cardiac ischaemic disease. The ubiquity of alopecia provides an encouragement to seek new, more effective therapies aimed at hair follicle regeneration and neoregeneration. We know that stem cells can be used to regenerate hair in several therapeutic strategies: reversing the pathological mechanisms which contribute to hair loss, regeneration of complete hair follicles from their parts, and neogenesis of hair follicles from a stem cell culture with isolated cells or tissue engineering. Hair transplant has become a conventional treatment technique in androgenic alopecia (micrografts). Although an autologous transplant is regarded as the gold standard, its usability is limited, because of both a limited amount of material and a reduced viability of cells obtained in this way. The new therapeutic options are adipose-derived stem cells and stem cells from Wharton's jelly. They seem an ideal cell population for use in regenerative medicine because of the absence of immunogenic properties and their ease of obtainment, multipotential character, ease of differentiating into various cell lines, and considerable potential for angiogenesis. In this article, we presented advantages and limitations of using these types of cells in alopecia treatment.
C1 [Owczarczyk-Saczonek, Agnieszka; Kruszewska, Anna; Placek, Waldemar] Univ Warmia & Mazury, Dept Dermatol Sexually Transmitted Dis & Clin Imm, Olsztyn, Poland.
   [Krajewska-Wlodarczyk, Magdalena] Univ Warmia & Mazury, Dept Rheumatol, Olsztyn, Poland.
   [Banasiak, Lukasz] Nicolaus Copernicus Univ Torun, L Rydygier Coll Med Bydgoszcz, Dept Plast Reconstruct & Aesthet Surg, Torun, Poland.
   [Maksymowicz, Wojciech] Univ Warmia & Mazury, Fac Med Sci, Dept Neurol & Neurosurg, Olsztyn, Poland.
   [Wojtkiewicz, Joanna] Univ Warmia & Mazury, Fdn Nerve Cell Regenerat, Olsztyn, Poland.
   [Wojtkiewicz, Joanna] Univ Warmia & Mazury, Fac Med Sci, Dept Pathophysiol, Olsztyn, Poland.
   [Wojtkiewicz, Joanna] Univ Warmia & Mazury, Fac Med Sci, Lab Regenerat Med, Olsztyn, Poland.
C3 University of Warmia & Mazury; University of Warmia & Mazury; Nicolaus
   Copernicus University; University of Warmia & Mazury; University of
   Warmia & Mazury; University of Warmia & Mazury; University of Warmia &
   Mazury
RP Owczarczyk-Saczonek, A (corresponding author), Univ Warmia & Mazury, Dept Dermatol Sexually Transmitted Dis & Clin Imm, Olsztyn, Poland.
EM aganek@wp.pl
RI Banasiak, Lukasz/AAU-3332-2021; Owczarczyk-Saczonek,
   Agnieszka/AAN-5260-2020; Wojtkiewicz, Joanna/AAD-8911-2019;
   Krajewska-Wlodarczyk, Magdalena/R-6218-2018
OI Krajewska-Wlodarczyk, Magdalena/0000-0002-7857-347X; Wojtkiewicz,
   Joanna/0000-0003-0856-3644
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NR 122
TC 52
Z9 56
U1 1
U2 14
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1687-966X
EI 1687-9678
J9 STEM CELLS INT
JI Stem Cells Int.
PY 2018
VL 2018
AR 1049641
DI 10.1155/2018/1049641
PG 16
WC Cell & Tissue Engineering
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA GQ8KK
UT WOS:000442003100001
PM 30154860
OA gold, Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Deveaux, A
   Pham, I
   West, SG
   André, E
   Lantoine-Adam, F
   Bunouf, P
   Sadi, S
   Hermier, D
   Mathé, V
   Fouillet, H
   Huneau, JF
   Benamouzig, R
   Mariotti, F
AF Deveaux, Ambre
   Pham, Isabelle
   West, Sheila G.
   Andre, Etienne
   Lantoine-Adam, Frederique
   Bunouf, Pierre
   Sadi, Samira
   Hermier, Dominique
   Mathe, Veronique
   Fouillet, Helene
   Huneau, Jean-Francois
   Benamouzig, Robert
   Mariotti, Francois
TI L-Arginine Supplementation Alleviates Postprandial Endothelial
   Dysfunction When Baseline Fasting Plasma Arginine Concentration Is Low:
   A Randomized Controlled Trial in Healthy Overweight Adults with
   Cardiometabolic Risk Factors
SO JOURNAL OF NUTRITION
LA English
DT Article
DE arginine metabolism; cardiometabolic risk; dietary arginine; high-fat
   meal; postprandial period
ID FLOW-MEDIATED DILATION; NITRIC-OXIDE SYNTHESIS; HIGH-FAT MEAL; OXIDATIVE
   STRESS GENERATION; PULSE AMPLITUDE TONOMETRY; TEST-RETEST RELIABILITY;
   ORAL L-ARGININE; ASYMMETRIC DIMETHYLARGININE; SIMVASTATIN TREATMENT;
   VASCULAR REACTIVITY
AB Background: Vascular endothelial dysfunction, the hallmark of early atherosclerosis, is induced transiently by a high-fat meal. High doses of free L-arginine supplements reduce fasting endothelial dysfunction.
   Objective: We sought to determine the effects of a low dose of a sustained-release (SR) L-arginine supplement on postprandial endothelial function in healthy overweight adults with cardiometabolic risk factors and to investigate whether this effect may vary by baseline arginine status.
   Methods: In a randomized, double-blind, 2-period crossover, placebo-controlled trial (4-wk treatment, 4-wk washout), we compared the effects of 1.5 g SR-L-arginine 3 times/d (4.5 g/d) with placebo in 33 healthy overweight adults [body mass index (BMI, in kg/m(2)): 25 to >30] with the hypertriglyceridemic waist (HTW) phenotype [plasma triglycerides > 150 mg/dL; waist circumference > 94 cm (men) or > 80 cm (women)]. The main outcome variable tested was postprandial endothelial function after a high fat meal (900 kcal), as evaluated by use of flow-mediated dilation (FMD) and Framingham reactive hyperemia index (fRHI), after each treatment. By use of subgroup analysis, we determined whether the effect was related to the baseline plasma arginine concentration.
   Results: In the total population, the effects of SR-arginine supplementation on postprandial endothelial function were mixed and largely varied with baseline fasting arginine concentration (P-interaction < 0.05). In the lower half of the population (below the median of 78.2 mu mol arginine/L plasma), but not the upper half, SR-arginine supplementation attenuated the postprandial decrease in both FMD (29% decrease with SR-arginine compared with 50% decrease with placebo) and fRHI (5% increase with SR-arginine compared with 49% decrease with placebo), resulting in significantly higher mean +/- SEM values with SR-arginine (FMD: 4.0% +/- 0.40%; fRHI: 0.41 +/- 0.069) than placebo (FMD: 2.9% +/- 0.31%; fRHI: 0.21 +/- 0.060) at the end of the postprandial period (P < 0.05).
   Conclusions: Supplementation with low-dose SR-arginine alleviates postprandial endothelial dysfunction in healthy HTW adults when the baseline plasma arginine concentration is relatively low. The benefits of arginine supplementation may be linked to a lower ability to mobilize endogenous arginine for nitric oxide synthesis during a postprandial challenge. This trial was registered at clinicaltrials.gov as NCT02354794.
C1 [Deveaux, Ambre; Sadi, Samira; Hermier, Dominique; Mathe, Veronique; Fouillet, Helene; Huneau, Jean-Francois; Benamouzig, Robert; Mariotti, Francois] Univ Paris Saclay, INRA, AgroParisTech, UMR Physiol Nutr & Comportement Alimentaire, Paris, France.
   [Pham, Isabelle] Jean Verdier Hosp, Assistance Publ Hop Paris, Dept Physiol & Funct Invest, Bondy, France.
   [West, Sheila G.] Penn State Univ, Dept Nutr Sci, University Pk, PA 16802 USA.
   [West, Sheila G.] Penn State Univ, Dept Biobehav Hlth, University Pk, PA 16802 USA.
   [Andre, Etienne; Lantoine-Adam, Frederique; Bunouf, Pierre] Inst Rech Pierre Fabre, Boulogne, France.
C3 Universite Paris Saclay; AgroParisTech; INRAE; Assistance Publique
   Hopitaux Paris (APHP); Universite Paris Cite; Hopital Universitaire
   Saint-Louis - APHP; Hopital Universitaire Jean-Verdier - APHP;
   Pennsylvania Commonwealth System of Higher Education (PCSHE);
   Pennsylvania State University; Penn State Behrend; Pennsylvania State
   University - University Park; Pennsylvania Commonwealth System of Higher
   Education (PCSHE); Pennsylvania State University; Pennsylvania State
   University - University Park; Penn State Behrend
RP Mariotti, F (corresponding author), Univ Paris Saclay, INRA, AgroParisTech, UMR Physiol Nutr & Comportement Alimentaire, Paris, France.
EM francois.mariotti@agroparistech.fr
RI BENAMOUZIG, Robert/W-8067-2019; Mariotti, Francois/F-9651-2017;
   Fouillet, Helene/K-7314-2012
OI Mariotti, Francois/0000-0002-4516-3853; West,
   Sheila/0000-0003-3488-8768; Fouillet, Helene/0000-0003-3932-251X;
   BENAMOUZIG, ROBERT/0000-0003-1952-6830
FU Pierre Fabre Research Institute
FX Supported by a grant from Pierre Fabre Research Institute.
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NR 58
TC 27
Z9 28
U1 0
U2 9
PU AMER SOC NUTRITION-ASN
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-3166
EI 1541-6100
J9 J NUTR
JI J. Nutr.
PD JUL
PY 2016
VL 146
IS 7
BP 1330
EP 1340
DI 10.3945/jn.115.227959
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA DQ7IL
UT WOS:000379380100007
PM 27281800
OA Bronze
DA 2025-06-11
ER

PT J
AU Ota, T
   Gayet, C
   Ginsberg, HN
AF Ota, Tsuguhito
   Gayet, Constance
   Ginsberg, Henry N.
TI Inhibition of apolipoprotein B100 secretion by lipid-induced hepatic
   endoplasmic reticulum stress in rodents
SO JOURNAL OF CLINICAL INVESTIGATION
LA English
DT Article
ID TRIGLYCERIDE TRANSFER PROTEIN; INSULIN-RESISTANCE; FATTY-ACIDS;
   INTRACELLULAR DEGRADATION; METABOLIC SYNDROME; ER STRESS; SODIUM
   4-PHENYLBUTYRATE; SELECTIVE-INHIBITION; B LIPOPROTEINS; LIVER-INJURY
AB ER stress can cause hepatic insulin resistance and steatosis. Increased VLDL secretion could protect the liver from ER stress-induced steatosis, but the effect of lipid-induced ER stress on the secretion of VLDL is unknown. To determine the effect of lipids on hepatic ER stress and VLDL secretion, we treated McA-RH7777 liver cells with free fatty acids. Prolonged exposure increased cell triglycerides, induced steatosis, and increased ER stress. Effects on apoB100 secretion, which is required for VLDL assembly, were parabolic, with moderate free fatty acid exposure increasing apoB100 secretion, while greater lipid loading inhibited apoB100 secretion. This decreased secretion at higher lipid levels was due to increased protein degradation through both proteasomal and nonproteasomal pathways and was dependent on the induction of ER stress. These findings were supported in vivo, where intravenous infusion of oleic acid (OA) in mice increased ER stress in a duration-dependent manner. apoB secretion was again parabolic, stimulated by moderate, but not prolonged, OA infusion. Inhibition of ER stress was able to restore OA-stimulated apoB secretion after prolonged OA infusion. These results suggest that excessive ER stress in response to increased hepatic lipids may decrease the ability of the liver to secrete triglycerides by limiting apoB secretion, potentially worsening steatosis.
C1 [Ota, Tsuguhito; Gayet, Constance; Ginsberg, Henry N.] Columbia Univ Coll Phys & Surg, Dept Med, New York, NY 10032 USA.
C3 Columbia University
RP Ginsberg, HN (corresponding author), Columbia Univ Coll Phys & Surg, Dept Med, PH 10-305,630 W 168th St, New York, NY 10032 USA.
EM hng1@columbia.edu
FU NHLBI NIH HHS [R01 HL073030, R01 HL055638] Funding Source: Medline
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NR 75
TC 303
Z9 350
U1 2
U2 36
PU AMER SOC CLINICAL INVESTIGATION INC
PI ANN ARBOR
PA 2015 MANCHESTER RD, ANN ARBOR, MI 48104 USA
SN 0021-9738
EI 1558-8238
J9 J CLIN INVEST
JI J. Clin. Invest.
PD JAN
PY 2008
VL 118
IS 1
BP 316
EP 332
DI 10.1172/JCI32752
PG 17
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 248AE
UT WOS:000252122900032
PM 18060040
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Bergman, M
   Lundholm, A
AF Bergman, Martin
   Lundholm, Amy
TI Mitigation of disease- and treatment-related risks in patients with
   psoriatic arthritis
SO ARTHRITIS RESEARCH & THERAPY
LA English
DT Review
DE Psoriatic arthritis; Disease-specific risks; Treatment-related risks;
   Psychological risks; Comorbidities; Quality of life; Risk; Review
ID ANTI-INTERLEUKIN-17A MONOCLONAL-ANTIBODY; PLACEBO-CONTROLLED TRIAL;
   QUALITY-OF-LIFE; DOUBLE-BLIND; ANKYLOSING-SPONDYLITIS;
   RHEUMATOID-ARTHRITIS; TREATMENT RECOMMENDATIONS; METABOLIC SYNDROME;
   SPONDYLOARTHRITIS; PREVALENCE
AB Psoriatic arthritis is a part of the family of diseases referred to as spondyloarthropathies, a diverse group of chronic inflammatory disorders with common clinical, radiographic, and genetic features. Peripheral arthritis is the most common symptom of psoriatic arthritis and patients also frequently experience involvement of the entheses, spine, skin, and nails. Due to the diverse clinical spectrum of disease severity, tissues affected, and associated comorbidities, the treatment of psoriatic arthritis can be challenging and it is necessary to mitigate risks associated with both the disease and its treatment. These risks include disease-specific, treatment-related, and psychological risks. Disease-specific risks include those associated with disease progression that can limit functional status and be mitigated through early diagnosis and initiation of treatment. Risks also arise from comorbidities that are associated with psoriatic arthritis such as cardiovascular disease, obesity, diabetes mellitus, and gastrointestinal inflammation. Patient outcomes can be affected by the treatment strategy employed and the pharmacologic agents administered. Additionally, it is important for physicians to be aware of risks specific to each therapeutic option. The impact of psoriatic arthritis is not limited to the skin and joints and it is common for patients to experience quality-of-life impairment. Patients are also more likely to have depression, anxiety, and alcoholism. This article reviews the many risks associated with psoriatic arthritis and provides guidance on mitigating these risks.
C1 [Bergman, Martin] Taylor Hosp, 8 Morton Ave,Suite 304, Ridley Pk, PA 19078 USA.
   [Lundholm, Amy] Lankenau Med Ctr, Wynnewood, PA USA.
C3 Lankenau Medical Center
RP Bergman, M (corresponding author), Taylor Hosp, 8 Morton Ave,Suite 304, Ridley Pk, PA 19078 USA.
EM mjbergman@prodigy.net
FU Novartis Pharmaceuticals Corporation
FX Technical assistance with editing and styling of the manuscript for
   submission was provided by Oxford PharmaGenesis Inc. and was funded by
   Novartis Pharmaceuticals Corporation.
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NR 74
TC 18
Z9 18
U1 0
U2 1
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1478-6354
EI 1478-6362
J9 ARTHRITIS RES THER
JI Arthritis Res. Ther.
PD MAR 20
PY 2017
VL 19
AR 63
DI 10.1186/s13075-017-1265-5
PG 8
WC Rheumatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Rheumatology
GA EO4KY
UT WOS:000396665000005
PM 28320454
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Park, SJ
   Park, JJ
   Choi, DJ
   Chun, EJ
   Choi, SI
   Kim, SM
   Jang, SY
   Ahn, S
   Choe, YH
AF Park, Sung-Ji
   Park, Jin Joo
   Choi, Dong-Ju
   Chun, Eun Ju
   Choi, Sang Il
   Kim, Sung Mok
   Jang, Shin Yi
   Ahn, Soyeon
   Choe, Yeon Hyeon
TI Understanding of chest pain in microvascular disease proved by cardiac
   magnetic resonance image (UMPIRE): study protocol for a randomized
   controlled trial
SO TRIALS
LA English
DT Article
DE Microvascular angina; PDE-5 inhibitors; Cardiac MRI
ID NORMAL CORONARY ANGIOGRAMS; LEFT-VENTRICULAR FUNCTION; SYNDROME-X;
   CLINICAL CHARACTERISTICS; ENDOTHELIAL DYSFUNCTION; MYOCARDIAL-ISCHEMIA;
   SILDENAFIL; ANGINA; VIAGRA; HYPERTENSION
AB Background: Microvascular angina (MVA) is characterized by anginal chest pain, an abnormal stress test, and normal coronary arteries on coronary angiography. Although the exact pathogenesis remains unclear, endothelial dysfunction is a contributing factor. To date, there exists no specific therapy for this disease. Phosphodiesterase-5 inhibitor improves the endothelial function and subsequently microvascular circulation. The aim of this study is to identify whether udenafil offers benefits in the treatment of MVA in female patients, who have a perfusion defect in their cardiac magnetic resonance image (CMR), but normal coronary arteries.
   Methods/Design: The 'Understanding of Chest Pain in Microvascular Disease Proved by Cardiac Magnetic Resonance Image: (UMPIRE)' trial is a multicenter, prospective, randomized, placebo controlled trial, designed to evaluate the effect of udenafil on myocardial ischemia and symptoms in female patients with MVA. The myocardial ischemia will be quantified by myocardial stress perfusion defect in CMR. A total of 80 patients with proven perfusion defect in adenosine-stress CMR will be randomly assigned to either the udenafil treatment group (daily dose of 100 mg) or the placebo group for three months. The primary endpoint is >25% improvement in perfusion defect size in adenosine-stress CMR from baseline. The secondary endpoints include <25% improvement in perfusion defect size, chest pain frequency, ST depression in stress test, Duke score in stress test, quality of life (QoL) assessment by SF-36 questionnaire, sexual dysfunction assessment by BISF-W (Brief Index of Sexual Functioning for Women) self-assessment questionnaire, and biomarkers for endothelial function.
   Discussion: The UMPIRE trial is the first randomized controlled trial to evaluate the efficacy of udenafil in female MVA patients. If udenafil demonstrates cardioprotective effects, it may provide a novel therapeutic option to reduce myocardial ischemia and improve cardiac function in female MVA patients.
C1 [Park, Sung-Ji; Kim, Sung Mok; Jang, Shin Yi; Choe, Yeon Hyeon] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Cardiovasc Imaging Ctr,Stroke Inst, Seoul 135710, South Korea.
   [Park, Jin Joo; Choi, Dong-Ju] Seoul Natl Univ, Coll Med, Bundang Hosp, Ctr Cardiovasc, Songnam 463707, Gyeonggi Do, South Korea.
   [Chun, Eun Ju; Choi, Sang Il] Seoul Natl Univ, Bundang Hosp, Coll Med, Dept Radiol, Songnam 463707, Gyeonggi Do, South Korea.
   [Ahn, Soyeon] Seoul Natl Univ, Bundang Hosp, Med Res Collaborating Ctr, Songnam 463707, Gyeonggi Do, South Korea.
C3 Sungkyunkwan University (SKKU); Samsung Medical Center; Seoul National
   University (SNU); Seoul National University (SNU); Seoul National
   University (SNU)
RP Choi, DJ (corresponding author), Seoul Natl Univ, Coll Med, Bundang Hosp, Ctr Cardiovasc, Gumiro 166, Songnam 463707, Gyeonggi Do, South Korea.
EM djchoi@snu.ac.kr
RI Choi, Sang-Il/AGR-1133-2022; Choe, Yeon/F-1422-2010; Ahn,
   Soyeon/NES-1216-2025; Choi, Dong-Ju/J-5686-2012; kim,
   sungmok/D-6143-2017
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NR 28
TC 6
Z9 6
U1 0
U2 2
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1745-6215
J9 TRIALS
JI Trials
PD AUG 26
PY 2014
VL 15
AR 333
DI 10.1186/1745-6215-15-333
PG 9
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA AO3FP
UT WOS:000341214900001
PM 25154607
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Gohar, SM
   Dieset, I
   Steen, NE
   Morch, RH
   Iversen, TS
   Steen, VM
   Andreassen, OA
   Melle, I
AF Gohar, Sherif M.
   Dieset, Ingrid
   Steen, Nils Eiel
   Morch, Ragni H.
   Iversen, Trude S.
   Steen, Vidar M.
   Andreassen, Ole A.
   Melle, Ingrid
TI Association between serum lipid levels, osteoprotegerin and depressive
   symptomatology in psychotic disorders
SO EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
LA English
DT Article
DE Depression; Dyslipidemia; Schizophrenia; Cholesterol; Cytokines; Bipolar
ID LOW-DENSITY-LIPOPROTEIN; METABOLIC SYNDROME; CARDIOVASCULAR-DISEASE;
   SCHIZOPHRENIA; SYMPTOMS; CHOLESTEROL; MORTALITY; SCALE; RISK;
   INFLAMMATION
AB Although the relationship between positive and negative symptoms of psychosis and dyslipidemia has been thoroughly investigated in recent studies, the potential link between depression and lipid status is still under-investigated. We here examined the association between lipid levels and depressive symptomatology in patients with psychotic disorders, in addition to their possible inflammatory associations. Participants (n = 652) with the following distribution: schizophrenia, schizophreniform and schizoaffective disorder (schizophrenia group, n = 344); bipolar I, II, NOS, and psychosis NOS (non-schizophrenia group, n = 308) were recruited consecutively from the Norwegian Thematically Organized Psychosis (TOP) Study. Clinical data were obtained by Positive and Negative Syndrome Scale (PANSS), and Calgary Depression Scale for Schizophrenia (CDSS). Blood samples were analyzed for total cholesterol (TC), low-density lipoprotein (LDL), triglyceride (TG), C-reactive protein (CRP), soluble tumor necrosis factor receptor 1(sTNF-R1), osteoprotegerin (OPG), and interleukin 1 receptor antagonist (IL-1Ra). After adjusting for age, gender, BMI, smoking, and dyslipidemia-inducing antipsychotics, TC and LDL scores showed significant associations with depression [beta = 0.13, p = 0.007; beta = 0.14, p = 0.007], and with two inflammatory markers: CRP [beta = 0.14, p = 0.007; beta = 0.16, p = 0.007] and OPG [beta = 0.14, p = 0.007; beta = 0.11, p = 0.007]. Total model variance was 17% for both analyses [F(12, 433) = 8.42, p < 0.001; F(12, 433) = 8.64, p < 0.001]. Current findings highlight a potential independent role of depression and inflammatory markers, CRP and OPG in specific, in the pathophysiology of dyslipidemia in psychotic disorders.
C1 [Gohar, Sherif M.; Dieset, Ingrid; Steen, Nils Eiel; Morch, Ragni H.; Iversen, Trude S.; Andreassen, Ole A.; Melle, Ingrid] Univ Oslo, KG Jebsen Ctr Psychosis Res, Inst Clin Med, NORMENT, Oslo, Norway.
   [Gohar, Sherif M.; Dieset, Ingrid; Steen, Nils Eiel; Morch, Ragni H.; Iversen, Trude S.; Andreassen, Ole A.; Melle, Ingrid] Oslo Univ Hosp, Ulleval Hosp, Div Mental Hlth & Addict, Psychosis Res Unit,TOP, Bldg 49,Kirkeveien 166, N-0424 Oslo, Norway.
   [Steen, Vidar M.] Univ Bergen, KG Jebsen Ctr Psychosis Res, Dept Clin Sci, NORMENT, Bergen, Norway.
   [Steen, Vidar M.] Haukeland Hosp, Ctr Med Genet & Mol Med, Dr Einar Martens Res Grp Biol Psychiat, Bergen, Norway.
   [Gohar, Sherif M.] Cairo Univ, Fac Med, Dept Psychiat, Cairo, Egypt.
C3 University of Oslo; University of Oslo; University of Bergen; University
   of Bergen; Haukeland University Hospital; Egyptian Knowledge Bank (EKB);
   Cairo University
RP Gohar, SM (corresponding author), Univ Oslo, KG Jebsen Ctr Psychosis Res, Inst Clin Med, NORMENT, Oslo, Norway.; Gohar, SM (corresponding author), Oslo Univ Hosp, Ulleval Hosp, Div Mental Hlth & Addict, Psychosis Res Unit,TOP, Bldg 49,Kirkeveien 166, N-0424 Oslo, Norway.; Gohar, SM (corresponding author), Cairo Univ, Fac Med, Dept Psychiat, Cairo, Egypt.
EM sherif.gohar@kasralainy.edu.eg; ingrid.dieset@medisin.uio.no;
   n.e.steen@medisin.uio.no; r.h.morch@medisin.uio.no;
   t.s.j.iversen@medisin.uio.no; vidar.martin.steen@helse-bergen.no;
   ole.andreassen@medisin.uio.no; ingrid.melle@medisin.uio.no
RI Melle, Ingrid/B-4858-2011; Gohar, Sherif/ABF-3812-2021; Andreassen,
   Ole/AAY-7531-2020; Steen, Nils Eiel/GRO-6284-2022
OI Gohar, Sherif/0000-0002-4420-5716
FU European Union [609020]; Research Council of Norway (Centres of
   Excellence funding scheme) [223273/F50]; Stiftelsen Kristian Gerhard
   Jebsen [SKGJ-MED-008]; Regional Health Authority South-Eastern Norway:
   "Regional Research Network Psychotic Disorders" [2014102]
FX The research leading to these results has received funding from the
   European Union Seventh Framework Programme (FP7-PEOPLE-2013-COFUND)
   under Grant agreement no. 609020-Scientia Fellows. In addition, the
   study was supported by grants from the Research Council of Norway to
   NORMENT CoE (Grant number 223273/F50, under the Centres of Excellence
   funding scheme), Stiftelsen Kristian Gerhard Jebsen (SKGJ-MED-008), and
   Regional Health Authority South-Eastern Norway: "Regional Research
   Network Psychotic Disorders" (2014102).
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NR 53
TC 18
Z9 18
U1 0
U2 5
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0940-1334
EI 1433-8491
J9 EUR ARCH PSY CLIN N
JI Eur. Arch. Psych. Clin. Neurosci.
PD OCT
PY 2019
VL 269
IS 7
BP 795
EP 802
DI 10.1007/s00406-018-0897-z
PG 8
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA IW9JK
UT WOS:000485309400005
PM 29721726
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Seydi-Shirvani, S
   Rasmi, Y
   Seyyed-Mohammadzad, MH
   Khosravifar, F
AF Seydi-Shirvani, Sam
   Rasmi, Yousef
   Seyyed-Mohammadzad, Mir-Hossein
   Khosravifar, Fariba
TI Oxidative stress status in patients with cardiac syndrome X
SO SCIENCEASIA
LA English
DT Article
DE microvascular dysfunction; antioxidant; angina pectoris
ID NORMAL CORONARY-ARTERIES; ENDOTHELIAL DYSFUNCTION; ANTIOXIDANT STATUS;
   ANGINA-PECTORIS; FREE-RADICALS; DAMAGE; NEBIVOLOL; PROGNOSIS; DISEASES
AB Cardiac syndrome X (CSX) is characterized by chest pain, typical angina pectoris, abnormal exercise test result and normal coronary arteries. Microvascular dysfunction and enhanced oxidative stress are the mechanisms suspected to play an important role in the pathogenesis of CSX. Thus we aimed to evaluate the oxidative stress status of 28 patients with CSX (14 male/14 female, mean age 49.5 +/- 9.3 years) and 24 age- and gender-matched healthy controls (10 male/14 female, mean age 45.6 +/- 5.7 years). Blood samples were drawn for measurement of malodialdehyde (MDA), as a marker of lipid peroxidation, glutathione (GSH) and superoxide dismutase (SOD) activity, as antioxidant markers and ferric reducing ability of plasma (FRAP), as a marker of total antioxidant capacity. There was significant increase in the levels of MDA in CSX patients comparing to controls (3.8 +/- 0.12 vs 3.3 +/- 0.14 mM, respectively; p = 0.006). But thelevels of FRAP in CSX patients were significantly lower than those controls (504 +/- 19 vs 568 +/- 26 mu M, respectively; p = 0.046). Also, GSH levels and SOD activity in patients were significantly lower than those of the controls (GSH: 133.6 +/- 5.4 vs 152.5 +/- 7.8 mmol/g Hb, p = 0.048; SOD: 386 +/- 34 vs 578 +/- 38 U/g Hb, p = 0.0001). It may be concluded that there is systemic oxidative stress in CSX patients. Considerable changes of antioxidant concentrations, indicating a compensatory mechanism to cope with increased oxidative stress in CSX patients and the body's antioxidant defence mechanisms try to minimize oxidative stress damage.
C1 [Rasmi, Yousef] Urmia Univ Med Sci, Ctr Cellular & Mol Res, Orumiyeh, Iran.
   [Seydi-Shirvani, Sam; Khosravifar, Fariba] Payame Noor Univ, Dept Biochem, Tehran, Iran.
   [Rasmi, Yousef] Urmia Univ Med Sci, Dept Biochem, Fac Med, Orumiyeh, Iran.
   [Seyyed-Mohammadzad, Mir-Hossein] Urmia Univ Med Sci, Fac Med, Dept Cardiol, Orumiyeh, Iran.
C3 Urmia University of Medical Sciences; Payame Noor University; Urmia
   University of Medical Sciences; Urmia University of Medical Sciences
RP Rasmi, Y (corresponding author), Urmia Univ Med Sci, Ctr Cellular & Mol Res, Orumiyeh, Iran.
EM rasmiy@unisu.ac.ir
RI Seyed-Mohammadzad, MirHossein/V-7699-2017; Rasmi, Prof.
   Yousef/H-1783-2017
OI Rasmi, Prof. Yousef/0000-0003-1506-1909
FU Urmia University of Medical Sciences, Urmia, Iran
FX This work derived from a Master of Science thesis in biochemistry and
   supported by research grant from the Urmia University of Medical
   Sciences, Urmia, Iran.
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NR 29
TC 2
Z9 3
U1 0
U2 4
PU SCIENCE SOCIETY THAILAND
PI BANGKOK
PA PUBLIC INFORMATION DEPT, 73/1 RAMA VI RD, RAJDHEVEE, BANGKOK, 00000,
   THAILAND
SN 1513-1874
J9 SCIENCEASIA
JI Scienceasia
PD JUN
PY 2012
VL 38
IS 2
BP 136
EP 140
DI 10.2306/scienceasia1513-1874.2012.38.136
PG 5
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 979MH
UT WOS:000306823600002
DA 2025-06-11
ER

PT J
AU Correia, J
   Ravasco, P
AF Correia, Jeronima
   Ravasco, Paula
TI Weight changes in Portuguese patients with depression: which factors are
   involved?
SO NUTRITION JOURNAL
LA English
DT Article
DE Depression; Nutrition; Weight changes; Food intake; Physical activity;
   Psychiatric drugs
ID PSYCHIATRIC-DISORDERS; METABOLIC SYNDROME; ABDOMINAL OBESITY;
   PHYSICAL-ACTIVITY; MAJOR DEPRESSION; OVERWEIGHT; ASSOCIATION; SYMPTOMS;
   HEALTH
AB Background & Aims: Depression may lead to obesity, just as obesity can contribute to the disease; yet, changes in the dietary pattern and food habits in depressive syndromes have been scantily investigated. We aimed to identify possible associations between nutritional factors and depressive disorder.
   Methods: This cross sectional study included 127 consecutive ambulatory adult patients with depression (DSM-IV), under psychiatric treatment. All study parameters were classified according to sex & age: BMI, waist circumference, % fat mass, food intake & physical activity.
   Results: Patients' mean age was 48 +/- 13 (18-81) yrs, 94% were women. Overweight/obesity was found in 72% of the cohort, 72% had excessive fat mass & 69% had a waist circumference above the maximum cut-off value. Longer disease was associated with higher BMI +% fat mass, p < 0.003. Weight gain during illness was registered in 87%; just 12% lost weight, though undernutrition did not occur. Weight gain and greater fat mass were related with higher BMI, p = 0.002. The pattern of food intake was poor, monotonous and inadequate in 59% of patients; there was also a regular consumption of hypercaloric foods by 78% pts. Overall, the usual diet was associated with weight gain, p = 0.002. Antidepressants (75%) and benzodiazepines (72%) were prevalent; these drugs were associated with weight gain, p = 0.01; 80% pts did not practice any physical activity.
   Conclusions: There was a positive association with overweight/obesity: a striking & clinically worrying prevalence of high fat mass, abdominal fat, weight gain, poor nutritional intake and sedentarism. This unhealthy pattern points towards the need of a multidisciplinary approach to promote healthy lifestyles that may help depressive disorder management.
C1 [Ravasco, Paula] Univ Lisbon, Fac Med, Lab Nutr, P-1649028 Lisbon, Portugal.
   [Ravasco, Paula] Hosp Univ Santa Maria, P-1649028 Lisbon, Portugal.
   [Correia, Jeronima] Hosp Nossa Senhora Rosario EPE, Psychiat Dept, Barreiro, Portugal.
C3 Universidade de Lisboa; Universidade de Lisboa; Hospital Santa Maria
RP Ravasco, P (corresponding author), Univ Lisbon, Fac Med, Lab Nutr, Ave Prof Egas Moniz, P-1649028 Lisbon, Portugal.
EM p.ravasco@medicina.ulisboa.pt
OI Ravasco, Paula/0000-0002-6056-8269
FU Fundacao para a Cincia e Tecnologia [RUN 437]
FX This study was partially supported by a Grant from the "Fundacao para a
   Cincia e Tecnologia" (RUN 437).
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NR 34
TC 14
Z9 17
U1 0
U2 18
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1475-2891
J9 NUTR J
JI Nutr. J.
PD DEC 16
PY 2014
VL 13
AR 117
DI 10.1186/1475-2891-13-117
PG 7
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nutrition & Dietetics
GA AX8XT
UT WOS:000347189700001
PM 25516181
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Shan, HY
   Luo, RX
   Guo, XY
   Li, R
   Ye, ZH
   Peng, TL
   Liu, FT
   Yang, Z
AF Shan, Hongying
   Luo, Renxin
   Guo, Xuanying
   Li, Rong
   Ye, Zhenhong
   Peng, Tianliu
   Liu, Fenting
   Yang, Zi
TI Abnormal Endometrial Receptivity and Oxidative Stress in Polycystic
   Ovary Syndrome
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Review
DE polycystic ovary syndrome; endometrial receptivity; oxidative stress;
   molecular mechanism; hyperandrogenemia
ID INSULIN-RESISTANCE; MONONUCLEAR-CELLS; MAMMALIAN TARGET;
   GRANULOSA-CELLS; WOMEN; HYPERANDROGENISM; PCOS; INFLAMMATION;
   EXPRESSION; LEVEL
AB Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder in women of childbearing age. Individual heterogeneity is evident, and the prevalence rate ranges between 6 and 15% globally. The prevalence rate of PCOS in Chinese women of childbearing age is 5.6%. The main manifestations are infertility, sparse menstruation, irregular vaginal bleeding, long-term endometrial hyperplasia, and endometrial cancer. PCOS is often associated with hyperandrogenemia, insulin resistance, hyperinsulinemia, obesity, metabolic syndrome, and intestinal flora disorder. Although there have been many studies in the past, the underlying pathophysiological mechanism of the disease is still unclear. Studies have shown that PCOS diseases and related complications are closely related to local oxidative stress imbalance in the endometrium, leading to poor endometrial receptivity and effects on pregnancy. Previous reviews have mainly focused on the abnormal mechanism of ovarian oxidative stress in women with PCOS, while reviews on endometrial receptivity and oxidative stress are relatively insufficient. This study reviews the abnormal cellular and molecular mechanisms of oxidative stress due to comorbidities in women with PCOS, leading to a downregulation of endometrial receptivity.
C1 [Shan, Hongying; Luo, Renxin; Guo, Xuanying; Li, Rong; Ye, Zhenhong; Peng, Tianliu; Liu, Fenting; Yang, Zi] Peking Univ Third Hosp, Ctr Reprod Med, Dept Obstet & Gynecol, Beijing, Peoples R China.
   [Shan, Hongying] Shihezi Univ, Affiliated Hosp 1, Sch Med, Beijing, Peoples R China.
C3 Shihezi University
RP Li, R (corresponding author), Peking Univ Third Hosp, Ctr Reprod Med, Dept Obstet & Gynecol, Beijing, Peoples R China.
EM roseli001@sina.com
RI Shan, Hongying/AAH-9946-2020; Li, Raymond/H-4442-2012; peng,
   Tianliu/MSW-1384-2025
OI peng, Tianliu/0000-0002-2680-2357
FU National Science Foundation for Distinguished Young Scholars [81925013];
   China Postdoctoral Science Foundation [2021M690259]
FX This study was supported by the "National Science Foundation for
   Distinguished Young Scholars, grant number 81925013" and the "China
   Postdoctoral Science Foundation grant number 2021M690259".
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NR 80
TC 27
Z9 29
U1 1
U2 28
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD JUL 25
PY 2022
VL 13
AR 904942
DI 10.3389/fphar.2022.904942
PG 8
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 3Q2IW
UT WOS:000838057800001
PM 35959444
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Khotskin, NV
   Plyusnina, AV
   Kulikova, EA
   Bazhenova, EY
   Fursenko, DV
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   Shevelev, OB
   Kulikov, AV
AF Khotskin, Nikita V.
   Plyusnina, Alexandra V.
   Kulikova, Elizabeth A.
   Bazhenova, Ekaterina Y.
   Fursenko, Daryia V.
   Sorokin, Ivan E.
   Kolotygin, Ilia
   Mormede, Pierre
   Terenina, Elena E.
   Shevelev, Oleg B.
   Kulikov, Alexander V.
TI On association of the lethal yellow (A<SUP>Y</SUP>) mutation in
   the agouti gene with the alterations in mouse brain and behavior
SO BEHAVIOURAL BRAIN RESEARCH
LA English
DT Article
DE Lethal yellow; Behavior; MRI; Brain; Mice
ID TYROSINE-PHOSPHATASE STEP; BODY-MASS INDEX; MELANOCORTIN-4 RECEPTOR;
   METABOLIC SYNDROME; MICE; PROTEIN; DEPRESSION; OBESITY; INFLAMMATION;
   EXPRESSION
AB Lethal yellow (A(Y)) mutation causes obesity and type-2 diabetes in mice. Here we studied the effect of the A(Y) mutation on the brain and behavior. The experiments were carried out on adult (11-12 weeks old) males of A(Y)/a mice and their wild-type littermates (a/a). Mice of A(Y)/a and a/a genotypes did not differ in their home cage activity, sleep, food and water consumption, learning ability in the Morris water maze, anxiety in the open field and elevated plus-maze, as well as in the level of monoamines, metabolites and some genes expression in the brain. At the same time, the fat mass, depressive-like immobility in the forced swim and tail suspension tests were significantly increased in A(Y)/a mice compared with a/a ones. Magnetic resonance imaging revealed a significant reduction of cortex volume in A(Y)/a mice. The level of mRNA of Ptpn5 gene encoding striatal enriched tyrosine phosphatase in the frontal cortex of A(Y)/a mice was significantly elevated compared with their wild-type littermates. This is the first report on the alterations in the brain and behavior in the A(Y)/a mouse line. It is tempting to speculate that this mouse line can serve as a new and useful preclinical model to study neurobehavioral complications associated with obesity and type-2 diabetes.
C1 [Khotskin, Nikita V.; Plyusnina, Alexandra V.; Kulikova, Elizabeth A.; Bazhenova, Ekaterina Y.; Fursenko, Daryia V.; Sorokin, Ivan E.; Shevelev, Oleg B.; Kulikov, Alexander V.] Inst Cytol & Genet SB RAS, Fed Res Ctr, Ave Lavrentyev 10, Novosibirsk 630090, Russia.
   [Kolotygin, Ilia] Novosibirsk State Univ, Novosibirsk 630090, Russia.
   [Mormede, Pierre; Terenina, Elena E.] Univ Toulouse, GenPhySE, INRA, INP,ENSAT,ENVT, F-31326 Castanet Tolosan, France.
C3 Russian Academy of Sciences; Siberian Branch of the Russian Academy of
   Sciences; Institute of Cytology & Genetics ICG SB RAS; Novosibirsk State
   University; Universite de Toulouse; Ecole Nationale Veterinaire de
   Toulouse; INRAE; Centre National de la Recherche Scientifique (CNRS);
   CNRS - Institute of Physics (INP); Universite Federale Toulouse
   Midi-Pyrenees (ComUE); Institut National Polytechnique de Toulouse
RP Kulikov, AV (corresponding author), Inst Cytol & Genet SB RAS, Fed Res Ctr, Ave Lavrentyev 10, Novosibirsk 630090, Russia.
EM akulikov@ngs.ru
RI Plyusnina, Aleksandra/ABA-9403-2020; Fursenko, Dariya/ABF-4273-2021;
   Kulikova, Elizabeth/AAD-4843-2020; Kulikov, Alexander/AAD-4870-2020;
   Khotskin, Nikita/AAE-9026-2020; Shevelev, Oleg/U-9436-2017; Mormede,
   Pierre/K-5537-2015
OI Fursenko, Dariya/0000-0003-0386-7315; Khotskin,
   Nikita/0000-0003-2187-2601; Terenina, Elena/0009-0005-1398-4525;
   Kulikova, Elizabeth/0000-0001-9102-1525; Mormede,
   Pierre/0000-0003-0345-1432
FU Russian Science Foundation [17-15-01032]; Russian Science Foundation
   [17-15-01032] Funding Source: Russian Science Foundation
FX The study has been supported by the Russian Science Foundation (grant No
   17-15-01032).
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NR 76
TC 27
Z9 27
U1 0
U2 10
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0166-4328
EI 1872-7549
J9 BEHAV BRAIN RES
JI Behav. Brain Res.
PD FEB 1
PY 2019
VL 359
BP 446
EP 456
DI 10.1016/j.bbr.2018.11.013
PG 11
WC Behavioral Sciences; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Behavioral Sciences; Neurosciences & Neurology
GA HI1RL
UT WOS:000456222600053
PM 30447239
DA 2025-06-11
ER

PT J
AU Ditzen, C
   Tang, N
   Jastorff, AM
   Teplytska, L
   Yassouridis, A
   Maccarrone, G
   Uhr, M
   Bronisch, T
   Miller, CA
   Holsboer, F
   Turck, CW
AF Ditzen, Claudia
   Tang, Ning
   Jastorff, Archana M.
   Teplytska, Larysa
   Yassouridis, Alexander
   Maccarrone, Giuseppina
   Uhr, Manfred
   Bronisch, Thomas
   Miller, Christine A.
   Holsboer, Florian
   Turck, Christoph W.
TI Cerebrospinal Fluid Biomarkers for Major Depression Confirm Relevance of
   Associated Pathophysiology
SO NEUROPSYCHOPHARMACOLOGY
LA English
DT Article
DE major depression; cerebrospinal fluid biomarkers; phosphoproteins; PEDF;
   cystatin C; PGDS
ID ELEMENT-BINDING PROTEIN; CELL-ADHESION MOLECULE; METABOLIC SYNDROME;
   ALZHEIMERS-DISEASE; SUICIDE ATTEMPTERS; PROSTAGLANDIN D-2; CYSTATIN-C;
   CSF; DISORDER; SLEEP
AB Individual characteristics of pathophysiology and course of depressive episodes are at present not considered in diagnostics. There are no biological markers available that can assist in categorizing subtypes of depression and detecting molecular variances related to disease-causing mechanisms between depressed patients. Identification of such differences is important to create patient subgroups, which will benefit from medications that specifically target the pathophysiology underlying their clinical condition. To detect characteristic biological markers for major depression, we analyzed the cerebrospinal fluid (CSF) proteome of depressed vs control persons, using two-dimensional polyacrylamide gel electrophoresis and time-of-flight (TOF) mass spectrometry peptide profiling. Proteins of interest were identified by matrix-assisted laser desorption ionization TOF mass spectrometry (MALDI-TOF-MS). Validation of protein markers was performed by immunoblotting. We found 11 proteins and 144 peptide features that differed significantly between CSF from depressed patients and controls. In addition, we detected differences in the phosphorylation pattern of several CSF proteins. A subset of the differentially expressed proteins implicated in brain metabolism or central nervous system disease was validated by immunoblotting. The identified proteins are involved in neuroprotection and neuronal development, sleep regulation, and amyloid plaque deposition in the aging brain. This is one of the first hypothesis-free studies that identify characteristic protein expression differences in CSF of depressed patients. Proteomic approaches represent a powerful tool for the identification of disease markers for subgroups of patients with major depression. Neuropsychopharmacology (2012) 37, 1013-1025; doi: 10.1038/npp.2011.285; published online 14 December 2011
C1 [Ditzen, Claudia; Jastorff, Archana M.; Teplytska, Larysa; Yassouridis, Alexander; Maccarrone, Giuseppina; Uhr, Manfred; Bronisch, Thomas; Holsboer, Florian; Turck, Christoph W.] Max Planck Inst Psychiat, D-80804 Munich, Germany.
   [Tang, Ning; Miller, Christine A.] Agilent Technol, Santa Clara, CA USA.
C3 Max Planck Society; Agilent Technologies
RP Ditzen, C (corresponding author), Max Planck Inst Psychiat, Kraepelinstr 2, D-80804 Munich, Germany.
EM ditzen@mpipsykl.mpg.de
RI Turck, Christoph/ADE-0191-2022; Miller, Christine/A-8950-2008
FU German Federal Ministry of Science and Education (NGFN MooDS)
FX This study was supported by the German Federal Ministry of Science and
   Education (NGFN MooDS).
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NR 44
TC 78
Z9 81
U1 0
U2 13
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0893-133X
EI 1740-634X
J9 NEUROPSYCHOPHARMACOL
JI Neuropsychopharmacology
PD MAR
PY 2012
VL 37
IS 4
BP 1013
EP 1025
DI 10.1038/npp.2011.285
PG 13
WC Neurosciences; Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA 896PB
UT WOS:000300580100017
PM 22169944
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Tapsell, LC
   Lonergan, M
   Martin, A
   Batterham, MJ
   Neale, EP
AF Tapsell, Linda C.
   Lonergan, Maureen
   Martin, Allison
   Batterham, Marijka J.
   Neale, Elizabeth P.
CA Hlth Track Study Team
TI Interdisciplinary lifestyle intervention for weight management in a
   community population (Health Track study): Study design and baseline
   sample characteristics
SO CONTEMPORARY CLINICAL TRIALS
LA English
DT Article
DE Interdisciplinary; Study protocol; Clinical trial; Health services;
   Overweight
ID PSYCHOMETRIC PROPERTIES; TRIAL; QUESTIONNAIRE; DIET; VALIDATION;
   ACCEPTANCE; PREVENTION; VALIDITY; WALNUTS; DISEASE
AB Background: Integrating professional expertise in diet, exercise and behavioural support may provide more effective preventive health services but this needs testing. We describe the design and baseline results of a trial in the Illawarra region of New South Wales, Australia.
   Methods: The HealthTrack study is a 12 month randomised controlled trial testing effects of a novel interdisciplinary lifestyle intervention versus usual care. The study recruited overweight and obese adults 25-54 years resident in the Illawarra. Primary outcomes were weight, and secondary outcomes were disease risk factors (lipids, glucose, blood pressure), and behaviour (diet, activity, and psychological factors). Protocols, recruitment and baseline characteristics are reported.
   Results: Between May 2014 and April 2015, 377 participants were recruited and randomised. The median age (IQR) of the mostly female sample (74%) was 45 (37-51) years. The sample comprised obese (BMI 32 (29-35) kg/m(2)) well educated (79% post school qualifications) non-smokers (96%). A high proportion reported suffering from anxiety (26.8%) and depression (33.7%). Metabolic syndrome was identified in 34.9% of the sample.
   Conclusions: The HealthTrack study sample was recruited to test the effectiveness of an interdisciplinary approach to preventive healthcare in self-identified overweight adults in the Illawarra region. The profile of participants gives some indication of those likely to use services similar to the trial design. (C) 2015 Elsevier Inc. All rights reserved.
C1 [Tapsell, Linda C.; Martin, Allison; Neale, Elizabeth P.] Univ Wollongong, Sch Med, Fac Sci Med & Hlth, Wollongong, NSW 2522, Australia.
   [Tapsell, Linda C.; Lonergan, Maureen; Martin, Allison; Neale, Elizabeth P.] Univ Wollongong, Illawarra Hlth & Med Res Inst, Wollongong, NSW 2522, Australia.
   [Lonergan, Maureen] Wollongong Hosp, Illawarrd Shoalhaven Local Hlth Dist, Renal Med, Wollongong, NSW 2500, Australia.
   [Batterham, Marijka J.] Univ Wollongong, Fac Engn & Informat Sci, Sch Math & Appl Stat, Stat Consulting Serv, Wollongong, NSW 2522, Australia.
C3 University of Wollongong; Illawarra Health & Medical Research Institute;
   University of Wollongong; Wollongong Hospital; University of Wollongong
RP Neale, EP (corresponding author), Univ Wollongong, Sch Med, Fac Sci Med & Hlth, Wollongong, NSW 2522, Australia.
EM elizan@uow.edu.au
RI Neale, Elizabeth/H-8514-2019; batterham, marijka/IQV-9028-2023; Probst,
   Yasmine/A-1342-2008; Ciarrochi, Joseph/F-5823-2016; Charlton,
   Karen/G-5906-2012
OI Tapsell, Linda/0000-0002-2546-6507; Probst, Yasmine/0000-0002-1971-173X;
   Batterham, Marijka/0000-0002-9520-6508; Russell,
   Joanna/0000-0002-0223-9256; Neale, Elizabeth/0000-0002-6373-8622;
   Ciarrochi, Joseph/0000-0003-0471-8100; Martin,
   Allison/0000-0001-6065-1188; Steel, David/0000-0002-3137-9952; Charlton,
   Karen/0000-0002-8044-444X; McMahon, Anne-Therese/0000-0001-9657-6001;
   Deane, Frank/0000-0002-6247-7416
FU Illawarra Health and Medical Research Institute; California Walnut
   Commission
FX This study was funded by the Illawarra Health and Medical Research
   Institute and the California Walnut Commission. The funding bodies were
   not involved in the analysis and interpretation of data, or writing of
   the report. Illawarra Health and Medical Research Institute facilities
   were used for conducting the study, including the collection of data.
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NR 50
TC 21
Z9 22
U1 0
U2 13
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1551-7144
EI 1559-2030
J9 CONTEMP CLIN TRIALS
JI Contemp. Clin. Trials
PD NOV
PY 2015
VL 45
BP 394
EP 403
DI 10.1016/j.cct.2015.10.008
PN B
PG 10
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA DA4FJ
UT WOS:000367755200037
PM 26498404
DA 2025-06-11
ER

PT J
AU Bettaieb, A
   Nagata, N
   AbouBechara, D
   Chahed, S
   Morisseau, C
   Hammock, BD
   Haj, FG
AF Bettaieb, Ahmed
   Nagata, Naoto
   AbouBechara, Daniel
   Chahed, Samah
   Morisseau, Christophe
   Hammock, Bruce D.
   Haj, Fawaz G.
TI Soluble Epoxide Hydrolase Deficiency or Inhibition Attenuates
   Diet-induced Endoplasmic Reticulum Stress in Liver and Adipose Tissue
SO JOURNAL OF BIOLOGICAL CHEMISTRY
LA English
DT Article
ID UNFOLDED PROTEIN RESPONSE; ER STRESS; EPOXYEICOSATRIENOIC ACIDS;
   GLUCOSE-HOMEOSTASIS; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   BLOOD-PRESSURE; MESSENGER-RNA; CELL-DEATH; OBESITY
AB Soluble epoxide hydrolase (sEH) is a cytosolic enzyme whose inhibition has beneficial effects in cardiovascular, inflammatory, and metabolic diseases in murine models. Mice with targeted deletion or pharmacological inhibition of sEH exhibit improved insulin signaling in liver and adipose tissue. Herein, we assessed the role of sEH in regulating endoplasmic reticulum (ER) stress in liver and adipose tissue. We report that sEH expression was increased in the livers and adipose tissue of mice fed a high fat diet, the adipose tissue of overweight humans, and palmitate-treated cells. Importantly, sEH deficiency or inhibition in mice attenuated chronic high fat diet-induced ER stress in liver and adipose tissue. Similarly, pharmacological inhibition of sEH in HepG2 cells and 3T3-L1 adipocytes mitigated chemical-induced ER stress and activation of JNK, p38, and cell death. In addition, insulin signaling was enhanced in HepG2 cells treated with sEH substrates and attenuated in cells treated with sEH products. In summary, these findings demonstrate that sEH is a physiological modulator of ER stress and a potential target for mitigating complications associated with obesity.
C1 [Bettaieb, Ahmed; Nagata, Naoto; AbouBechara, Daniel; Chahed, Samah; Haj, Fawaz G.] Univ Calif Davis, Dept Nutr, Davis, CA 95616 USA.
   [Morisseau, Christophe; Hammock, Bruce D.] Univ Calif Davis, Dept Entomol, Davis, CA 95616 USA.
   [Haj, Fawaz G.] Univ Calif Davis, Dept Internal Med, Davis, CA 95616 USA.
   [Morisseau, Christophe; Hammock, Bruce D.; Haj, Fawaz G.] Univ Calif Davis, Ctr Comprehens Canc, Davis, CA 95616 USA.
C3 University of California System; University of California Davis;
   University of California System; University of California Davis;
   University of California System; University of California Davis;
   University of California System; University of California Davis
RP Haj, FG (corresponding author), Univ Calif Davis, Dept Nutr, 3135 Meyer Hall, Davis, CA 95616 USA.
EM fghaj@ucdavis.edu
RI Nagata, Naoto/D-9261-2012
OI Nagata, Naoto/0000-0002-2389-2334; Morisseau,
   Christophe/0000-0002-5672-6631
FU National Institutes of Health [R56 DK084317, R01 DK090492, ES02710];
   Superfund Basic Research Program from NIEHS [P42 ES04699]; NHLBI
   [HL059699]; Juvenile Diabetes Research Foundation [1-2009-337]
FX This work was supported, in whole or in part, by National Institutes of
   Health Grants R56 DK084317 and R01 DK090492 (to F. G. H.) and by
   National Institutes of Health Grant ES02710 and Superfund Basic Research
   Program Grant P42 ES04699 from NIEHS and Grant HL059699 from NHLBI (to
   B. D. H.). This work was also supported by Juvenile Diabetes Research
   Foundation Research Grant 1-2009-337 (to F. G. H.).
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NR 66
TC 108
Z9 123
U1 0
U2 17
PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3996 USA
EI 1083-351X
J9 J BIOL CHEM
JI J. Biol. Chem.
PD MAY 17
PY 2013
VL 288
IS 20
BP 14189
EP 14199
DI 10.1074/jbc.M113.458414
PG 11
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 148OB
UT WOS:000319253500023
PM 23576437
OA Green Published
DA 2025-06-11
ER

PT J
AU Gardea-Resendez, M
   Winham, SJ
   Romo-Nava, F
   Cuellar-Barboza, A
   Clark, MM
   Andreazza, AC
   Cabello-Arreola, A
   Veldic, M
   Bond, DJ
   Singh, B
   Prieto, ML
   Nunez, NA
   Betcher, H
   Moore, KM
   Blom, T
   Colby, C
   Pendegraft, RS
   Kelpin, SS
   Ozerdem, A
   Miola, A
   De Filippis, E
   Biernacka, JM
   McElroy, SL
   Frye, MA
AF Gardea-Resendez, Manuel
   Winham, Stacey J.
   Romo-Nava, Francisco
   Cuellar-Barboza, Alfredo
   Clark, Matthew M.
   Andreazza, Ana Cristina
   Cabello-Arreola, Alejandra
   Veldic, Marin
   Bond, David J.
   Singh, Balwinder
   Prieto, Miguel L.
   Nunez, Nicolas A.
   Betcher, Hannah
   Moore, Katherine M.
   Blom, Thomas
   Colby, Colin
   Pendegraft, Richard S.
   Kelpin, Sydney S.
   Ozerdem, Aysegul
   Miola, Alessandro
   De Filippis, Eleanna
   Biernacka, Joanna M.
   McElroy, Susan L.
   Frye, Mark A.
TI Quantification of diet quality utilizing the rapid eating assessment for
   participants-shortened version in bipolar disorder: Implications for
   prospective depression and cardiometabolic studies
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Bipolar disorder; Diet quality; Cardiometabolic markers; Obesity;
   Bipolar depression
ID METABOLIC SYNDROME; SYMPTOMS; RISK; OBESITY; WOMEN; REAP; SCHIZOPHRENIA;
   VALIDATION; INVENTORY; NUTRITION
AB Objectives: Recognizing bipolar disorder as a multi-system metabolic condition driven, in part, by binge eating behavior and atypical depressive symptoms, this study aimed to quantify diet quality and evaluate clinical correlates in a bipolar disorder cohort. Methods: Participants from the Mayo Clinic Bipolar Disorder Biobank (n = 734) completed the Rapid Eating Assessment for Participants - Shortened version (REAP-S) to determine diet quality. The average REAP-S score for a U.S. omnivorous diet is 32 (range 13 to 39) with higher scores indicating healthier diet. Demographic variables were collected in a standardized clinical questionnaire. Depressive symptoms were assessed by the Bipolar Inventory of Symptoms Scale. Cardiometabolic variables were retrieved from the electronic health record. Associations between continuous variables and REAP-S scores (total, 'healthy foods' and 'avoidance of unhealthy foods') were assessed using linear regression. Results: Overall, our sample had a mean REAP-S score of 27.6 (4.9), suggestive of a lower diet quality than the average general population in the US. There was a significant inverse relationship between mean REAP-S lower scores with increased BMI, waist circumference, disordered eating and depression. All these associations were significantly stronger in female participants. Limitations: EHR cross-sectional data. Conclusions: Our data suggest unhealthy diet quality in bipolar disorder is associated with depression, obesity and cardiometabolic abnormalities. Additional work is encouraged to prospectively track mood and diet quality to further understand the bidirectional relationship and clarify if dietary interventions can positively impact mood. Further delineating potential sex differences in diet quality and depression may provide greater appreciation of modifiable risk factors for future cardiometabolic burden.
C1 [Gardea-Resendez, Manuel; Clark, Matthew M.; Cabello-Arreola, Alejandra; Veldic, Marin; Singh, Balwinder; Prieto, Miguel L.; Nunez, Nicolas A.; Betcher, Hannah; Moore, Katherine M.; Kelpin, Sydney S.; Ozerdem, Aysegul; Biernacka, Joanna M.; Frye, Mark A.] Mayo Clin, Dept Psychiat & Psychol, Rochester, MN USA.
   [Winham, Stacey J.; Colby, Colin; Pendegraft, Richard S.; Biernacka, Joanna M.] Mayo Clin, Dept Quantitat Hlth Sci, Rochester, MN USA.
   [Romo-Nava, Francisco; Blom, Thomas; McElroy, Susan L.] Univ Cincinnati, Lindner Ctr HOPE, Dept Psychiat & Behav Neurosci, Coll Med, Mason, OH USA.
   [Cuellar-Barboza, Alfredo] Univ Autonoma Nuevo Leon, Dept Psychiat, Monterrey, Mexico.
   [Andreazza, Ana Cristina] Univ Toronto, Temerty Fac Med, Dept Pharmacol & Toxicol & Psychiat, Toronto, ON, Canada.
   [Bond, David J.] Univ Minnesota, Dept Psychiat & Behav Sci, Med Sch, Minneapolis, MN USA.
   [Prieto, Miguel L.] Univ Andes, Fac Med, Dept Psychiat, Santiago, Chile.
   [Prieto, Miguel L.] Clin Univ Andes, Mental Hlth Serv, Santiago, Chile.
   [Prieto, Miguel L.] Univ Andes, Ctr Biomed Res & Innovat, Santiago, Chile.
   [Miola, Alessandro] Univ Hosp Padova, Dept Neurosci, Psychiat Unit, Padua, Italy.
   [De Filippis, Eleanna] Mayo Clin, Dept Endocrinol, Scottsdale, AZ USA.
   [Frye, Mark A.] Mayo Clin, Dept Psychiat & Psychol, 200 1st St SW, Rochester, MN 55902 USA.
C3 Mayo Clinic; Mayo Clinic; University System of Ohio; University of
   Cincinnati; Universidad Autonoma de Nuevo Leon; University of Toronto;
   University of Minnesota System; University of Minnesota Twin Cities;
   Universidad de los Andes - Chile; Universidad de los Andes - Chile;
   Universidad de los Andes - Chile; University of Padua; Azienda
   Ospedaliera - Universita di Padova; Mayo Clinic; Mayo Clinic Phoenix;
   Mayo Clinic
RP Frye, MA (corresponding author), Mayo Clin, Dept Psychiat & Psychol, 200 1st St SW, Rochester, MN 55902 USA.
EM mfrye@mayo.edu
RI Cuellar-Barboza, Alfredo/A-9278-2015; Singh, Balwinder/H-2016-2011;
   Gardea Resendez, Manuel/LZE-8888-2025; Miola, Alessandro/LMP-0749-2024;
   Nunez, Nicolas/HPD-4606-2023; Veldic, Marin/N-7705-2017; Andreazza, Ana
   Cristina/P-8562-2018
OI Andreazza, Ana Cristina/0000-0002-4323-7273; Gardea Resendez,
   Manuel/0000-0002-9825-8792; Romo-Nava, Francisco/0000-0002-5894-3701;
   OZERDEM, AYSEGUL/0000-0002-9455-5896; Bond, David/0000-0002-8713-7311
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NR 54
TC 9
Z9 9
U1 0
U2 3
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD AUG 1
PY 2022
VL 310
BP 150
EP 155
DI 10.1016/j.jad.2022.05.037
EA MAY 2022
PG 6
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA 2F6WM
UT WOS:000813048100018
PM 35545158
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Yamada, S
   Kimura, M
   Saito, Y
   Saito, H
AF Yamada, Shoji
   Kimura, Masaki
   Saito, Yoshimasa
   Saito, Hidetsugu
TI Nrf2-mediated anti-oxidant effects contribute to suppression of
   non-alcoholic steatohepatitis-associated hepatocellular carcinoma in
   murine model
SO JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION
LA English
DT Article
DE hepatocellular carcinoma; gut microbiota; oxidative stress; anti-oxidant
   effect
ID SIGNIFICANT LIVER FIBROSIS; OXIDATIVE STRESS; GENE-EXPRESSION;
   RISK-FACTORS; METABOLIC SYNDROME; CLINICAL-FEATURES; IMMUNE-RESPONSE;
   NRF2; HEPATOCARCINOGENESIS; INFLAMMATION
AB The exact mechanisms of hepatocellular carcinoma development in non-alcoholic steatohepatitis remain unclear. In this study, we used a new class of high-fat diet, which could induce hepatocellular carcinoma development without the use of general chemical carcinogens or knockout mice. We investigated the correlation between hepatocellular carcinoma and oxidative stress/anti-oxidant effects after depletion of the gut microbiota by treatment with antibiotics. Mice fed with the steatohepatitis-inducing high fat diet (STHD-01) for 41 weeks developed hepatocellular carcinoma. Antibiotic-treatment in mice fed with STHD-01 significantly depleted the gut microbiota and significantly ameliorated liver injury/histology. The tumor numbers of hepatocellular carcinoma were dramatically decreased by the antibiotics-treatment. We analyzed the factors involved in oxidative stress and anti-oxidant effects. Oxidative stress was elevated in mice fed with STHD-01, whereas some anti-oxidant factors were significantly elevated after antibiotics treatment. These results suggest that the gut microbiota is a key factor in improving oxidative stress induced by STHD-01 feeding.
C1 [Yamada, Shoji; Kimura, Masaki; Saito, Yoshimasa; Saito, Hidetsugu] Keio Univ, Fac Pharm, Div Pharmacotherapeut, Minato Ku, 1-5-30 Shibakoen, Tokyo 1058512, Japan.
   [Saito, Yoshimasa; Saito, Hidetsugu] Keio Univ, Dept Internal Med, Div Gastroenterol & Hepatol, Shinjuku Ku, 35 Shinanomachi, Tokyo 1608582, Japan.
C3 Keio University; Keio University
RP Saito, H (corresponding author), Keio Univ, Fac Pharm, Div Pharmacotherapeut, Minato Ku, 1-5-30 Shibakoen, Tokyo 1058512, Japan.; Saito, H (corresponding author), Keio Univ, Dept Internal Med, Div Gastroenterol & Hepatol, Shinjuku Ku, 35 Shinanomachi, Tokyo 1608582, Japan.
EM hsaito@a2.keio.jp
FU Depaitment of Pathology, Keio University school of Medicine; MEXT, Japan
   [JCM1649T]; Keio University Fukuzawa Memorial Fund; Japan Society for
   Promotion of Science [15K09021]; Grants-in-Aid for Scientific Research
   [15K09021] Funding Source: KAKEN
FX I would like to thank Drs. Ken Yamazaki and Michiie Sakamoto, Depaitment
   of Pathology, Keio University school of Medicine, for their generous
   support in analyzing the pathological findings. The Escherichia coli
   JCM1649T genome DNA was provided by the RIKEN BRC through the
   Bio-Resource Project of the MEXT, Japan.This work was supported by Keio
   University Fukuzawa Memorial Fund (to HS) and Grant-in-Aid for
   Scientific Research C (15K09021) from the Japan Society for Promotion of
   Science (to HS). The fund was used to obtain materials.
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NR 37
TC 2
Z9 2
U1 1
U2 7
PU JOURNAL CLINICAL BIOCHEMISTRY & NUTRITION
PI KYOTO
PA KYOTO PREFECTURAL UNIV MED, GRAD SCH MEDICAL SCIENCE, DEPT MOLECULAR
   GASTROENTEROLOGY & HEPATOLOGY, KYOTO, 602-8566, JAPAN
SN 0912-0009
EI 1880-5086
J9 J CLIN BIOCHEM NUTR
JI J. Clin. Biochem. Nutr.
PD SEP 1
PY 2018
VL 63
IS 2
BP 123
EP 128
DI 10.3164/jcbn.17-125
PG 6
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA GW1MV
UT WOS:000446644600007
PM 30279623
OA gold, Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Lu, Y
   Wang, MX
   Bao, JX
   Chen, DS
   Jiang, H
AF Lu, Yi
   Wang, Meixiang
   Bao, Jiaxin
   Chen, Dashuang
   Jiang, Hao
TI Association between oxidative balance score and metabolic syndrome and
   its components in US adults: a cross-sectional study from NHANES
   2011-2018
SO FRONTIERS IN NUTRITION
LA English
DT Article
DE oxidative balance score (OBS); metabolic syndrome; NHANES; oxidative
   stress; antioxidant
ID STRESS; INFLAMMATION; ANTIOXIDANT; OBESITY; HYPERTENSION; DISEASE
AB Background Metabolic syndrome (MetS) is a global health concern that threatens human well-being. The oxidative balance score (OBS) is a tool to identify the level of oxidative stress that is correlated with MetS risk. However, association between OBS and MetS and its components has not been reported. Methods This cross-sectional study included adult individuals with complete OBS and MetS data from National Health and Nutrition Examination Survey (NHANES) 2011-2018. A weighted logistic regression analysis was conducted to identify the association of the total, dietary, and lifestyle OBS scores with MetS. Subgroup analyses and restricted cubic splines were used to further explore associations. Results In total, 10,025 eligible adult individuals (51.48% were males at a median age of 46 years) were included, with a MetS prevalence of 29.98%. In fully adjusted model, higher total OBS was associated with reduced risk of MetS (Q3 vs. Q1: odds ratio [OR] = 0.57, 95% confidence interval [CI], 0.46-0.71, p < 0.001; Q4 vs. Q1: OR = 0.42, 95% CI, 0.33-0.53, p < 0.001; P for trend <0.001). Significant differences were observed in the relationship between dietary OBS and lifestyle OBS and MetS risk (continuous dietary OBS: OR = 0.97, 95% CI, 0.96-0.98, p < 0.001; continuous lifestyle OBS: OR = 0.61, 95% CI, 0.58-0.64, p < 0.001), as well as negative relationship between total OBS and risk of five MetS components (all p < 0.05). Subgroup analysis showed marital status modified the negative association between OBS and MetS in subgroup analysis (P for interaction = 0.014). Moreover, a nonlinear correlation between OBS and MetS (including its components) was found, further elucidating associations (all p < 0.05). Restricted cubic splines demonstrated not obviously U-shape correlation between OBS and MetS components (elevated triglyceride and blood pressure). Conclusion This study suggests a strong association between the OBS and MetS and its components. Our data indicated that a higher OBS score was correlated with a decreased risk of MetS and its components in a nonlinear manner. Hence, the OBS may serve as an effective marker for identifying individuals with MetS, with a higher score indicating a predominance of more antioxidants.
C1 [Lu, Yi; Wang, Meixiang; Jiang, Hao] Nanjing Med Univ, Affiliated Taizhou Peoples Hosp, Taizhou Sch Clin Med, Dept Cardiol, Taizhou, Peoples R China.
   [Bao, Jiaxin] Nanjing Med Univ, Affiliated Taizhou Peoples Hosp, Taizhou Sch Clin Med, Dept Nephrol, Taizhou, Peoples R China.
   [Chen, Dashuang] Nanjing Med Univ, Affiliated Taizhou Peoples Hosp, Taizhou Sch Clin Med, Dept Gen Med, Taizhou, Peoples R China.
C3 Nanjing Medical University; Nanjing Medical University; Nanjing Medical
   University
RP Jiang, H (corresponding author), Nanjing Med Univ, Affiliated Taizhou Peoples Hosp, Taizhou Sch Clin Med, Dept Cardiol, Taizhou, Peoples R China.
EM jianghao555666@163.com
RI Chen, Dashuang/HTM-8417-2023
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NR 50
TC 15
Z9 15
U1 2
U2 12
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD MAR 13
PY 2024
VL 11
AR 1375060
DI 10.3389/fnut.2024.1375060
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA MB3W2
UT WOS:001191136900001
PM 38544757
OA gold, Green Published
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Flamment, M
   Kammoun, HL
   Hainault, I
   Ferré, P
   Foufelle, F
AF Flamment, Melissa
   Kammoun, Helene L.
   Hainault, Isabelle
   Ferre, Pascal
   Foufelle, Fabienne
TI Endoplasmic reticulum stress: a new actor in the development of hepatic
   steatosis
SO CURRENT OPINION IN LIPIDOLOGY
LA English
DT Review
DE endoplasmic reticulum stress; hepatic steatosis; lipogenesis; metabolic
   syndrome
ID ELEMENT-BINDING PROTEIN; INSULIN-RESISTANCE; ER STRESS; GENE-EXPRESSION;
   FATTY-ACIDS; NONALCOHOLIC STEATOHEPATITIS; TRANSCRIPTION FACTOR;
   GLUCOSE-HOMEOSTASIS; LIVER-INJURY; ACTIVATION
AB Purpose of review
   To examine the role of endoplasmic reticulum stress in the regulation of hepatic lipid metabolism and its contribution to the development of hepatic steatosis.
   Recent findings
   Endoplasmic reticulum stress activation has been reported in most models of hepatic steatosis in rodents and humans and its contribution to hepatic fat deposition has been recently documented. The main metabolic pathway affected by endoplasmic reticulum stress is lipogenesis. Endoplasmic reticulum stress activates the proteolytic cleavage of the lipogenic transcription factor sterol regulatory element binding protein-1c leading to the induction of lipogenic enzyme expression. A role for X box-binding protein 1, an endoplasmic reticulum stress-activated transcription factor, has also recently emerged. Endoplasmic reticulum stress, by inhibiting apoB100 secretion, has associated with impaired VLDL secretion. In rodents, treatments with molecular or chemical chaperones that reduce endoplasmic reticulum stress markers have fully demonstrated their efficiency in the treatment of hepatic steatosis.
   Summary
   Manipulating endoplasmic reticulum stress pathway yields encouraging results for the treatment of hepatic steatosis in rodents. However, activation of unfolded protein response is a physiological mechanism, which is particularly important for secretory cells such as hepatocytes and the long-term consequences of such treatments should be cautiously evaluated.
C1 [Foufelle, Fabienne] Ctr Rech Cordeliers, INSERM, UMR S 872, F-75006 Paris, France.
   Univ Paris 06, Paris, France.
C3 Universite Paris Cite; Sorbonne Universite; Institut National de la
   Sante et de la Recherche Medicale (Inserm); Sorbonne Universite
RP Foufelle, F (corresponding author), Ctr Rech Cordeliers, INSERM, UMR S 872, 15 Rue Ecole Med, F-75006 Paris, France.
EM fabienne.foufelle@crc.jussieu.fr
RI Ferre, Pascal/K-1250-2013
OI Ferre, Pascal/0000-0003-0115-7045; FOUFELLE,
   Fabienne/0000-0002-0752-622X
FU INSERM; Agence Nationale de la Recherche [ANR-2005-PCOD-035]; European
   Commission [LSHM-CT- 2004-005272]; Ministere de la Recherche et de
   l'Enseignement superieur; Fondation pour la Recherche Medicale; 'Region
   Ile de France'
FX The present work was supported by grants from INSERM, the Agence
   Nationale de la Recherche (ANR-2005-PCOD-035), Alfediam Takeda and from
   the EXGENESIS Integrated Project Grant LSHM-CT- 2004-005272 funded by
   the European Commission. H. L. K. is a recipient of a doctoral
   fellowship from the Ministere de la Recherche et de l'Enseignement
   superieur and from the Fondation pour la Recherche Medicale. M. F. is
   supported by a postdoctoral grant from the 'Region Ile de France'.
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NR 66
TC 56
Z9 64
U1 3
U2 39
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0957-9672
EI 1473-6535
J9 CURR OPIN LIPIDOL
JI Curr. Opin. Lipidology
PD JUN
PY 2010
VL 21
IS 3
BP 239
EP 246
DI 10.1097/MOL.0b013e3283395e5c
PG 8
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism; Peripheral
   Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism;
   Cardiovascular System & Cardiology
GA 601ZG
UT WOS:000278106300011
PM 20463471
DA 2025-06-11
ER

PT J
AU Tamashiro, KL
   Sakai, RR
   Shively, CA
   Karatsoreos, IN
   Reagan, LP
AF Tamashiro, K. L.
   Sakai, R. R.
   Shively, C. A.
   Karatsoreos, I. N.
   Reagan, L. P.
TI Chronic stress, metabolism, and metabolic syndrome
SO STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS
LA English
DT Review
DE Cardiovascular disease; circadian disruption; diabetes mellitus;
   glucocorticoids; obesity; social stress
ID CHRONIC SOCIAL STRESS; INSULIN-STIMULATED TRANSLOCATION; BODY-WEIGHT;
   SUBORDINATION STRESS; DOWN-REGULATION; DIABETIC-RATS; SHIFT WORK; MODEL;
   OBESITY; CORTICOSTERONE
AB The prevalence of obesity has rapidly escalated and now represents a major public health concern. Although genetic associations with obesity and related metabolic disorders such as diabetes and cardiovascular disease have been identified, together they account for a small proportion of the incidence of disease. Environmental influences such as chronic stress, behavioral and metabolic disturbances, dietary deficiency, and infection have now emerged as contributors to the development of metabolic disease. Although epidemiological data suggest strong associations between chronic stress exposure and metabolic disease, the etiological mechanisms responsible remain unclear. Mechanistic studies of the influence of chronic social stress are now being conducted in both rodent and nonhuman primate models, and phenotypic results are consistent with those in humans. The advantage of these models is that potential neural mechanisms may be examined and interventions to treat or prevent disease may be developed and tested. Further, circadian disruption and metabolic conditions such as diabetes mellitus could increase susceptibility to other stressors or serve as a stressor itself. Here, we review data from leading investigators discussing the interrelationship between chronic stress and development of metabolic disorders.
C1 [Tamashiro, K. L.] Johns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, Baltimore, MD 21205 USA.
   [Sakai, R. R.] Univ Cincinnati, Coll Med, Dept Psychiat & Behav Sci, Cincinnati, OH USA.
   [Shively, C. A.] Wake Forest Univ, Ctr Primate, Dept Pathol Comparat Med, Winston Salem, NC 27109 USA.
   [Karatsoreos, I. N.] Rockefeller Univ, Neuroendocrinol Lab, New York, NY 10021 USA.
   [Reagan, L. P.] Univ S Carolina, Sch Med, Dept Pharmacol Physiol & Neurosci, Columbia, SC USA.
C3 Johns Hopkins University; University System of Ohio; University of
   Cincinnati; Wake Forest University; Rockefeller University; University
   of South Carolina System; University of South Carolina Columbia
RP Tamashiro, KL (corresponding author), Johns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, 720 Rutland Ave,Ross 618, Baltimore, MD 21205 USA.
EM ktamashiro@jhmi.edu
RI Karatsoreos, Ilia/AAR-8774-2020; Shively, Carol/L-2921-2019
OI Tamashiro, Kellie/0000-0002-9398-8796
FU NIMH [R13MH090623]
FX We acknowledge grant support from NIMH R13MH090623.
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Z9 159
U1 0
U2 48
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1025-3890
EI 1607-8888
J9 STRESS
JI Stress
PD SEP
PY 2011
VL 14
IS 5
BP 468
EP 474
DI 10.3109/10253890.2011.606341
PG 7
WC Behavioral Sciences; Endocrinology & Metabolism; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Behavioral Sciences; Endocrinology & Metabolism; Neurosciences &
   Neurology
GA 808VC
UT WOS:000294008400002
PM 21848434
DA 2025-06-11
ER

PT J
AU Ge, XM
   Liu, Z
   Qi, W
   Shi, XL
   Zhai, QW
AF Ge, Xuemei
   Liu, Zhen
   Qi, Wei
   Shi, Xianglin
   Zhai, Qiwei
TI Chromium (VI) induces insulin resistance in 3T3-L1 adipocytes through
   elevated reactive oxygen species generation
SO FREE RADICAL RESEARCH
LA English
DT Article
DE Cr(VI); insulin resistance; ROS; ER stress; JNK
ID INCREASED OXIDATIVE STRESS; HYDROXYL RADICAL FORMATION; PROTEIN-KINASE
   B; MITOCHONDRIAL DYSFUNCTION; ENDOPLASMIC-RETICULUM;
   SIGNAL-TRANSDUCTION; METABOLIC SYNDROME; HYDROGEN-PEROXIDE; ER STRESS;
   INFLAMMATION
AB Reactive oxygen species (ROS) have been proposed to be involved in the development of insulin resistance, although the exact molecular link between ROS and insulin resistance remains to be determined. Chromium (Cr(VI)) is known as an inducer of ROS. Therefore, this study examined whether Cr(VI) could induce insulin resistance. It demonstrated that Cr(VI) treatment significantly inhibited insulin-stimulated glucose uptake and attenuated insulin signalling. Moreover, Cr(VI) treatment markedly increased the intracellular levels of superoxide anion, hydrogen peroxide and hydroxyl radical. N-acetylcysteine, superoxide dismutase and catalase can block the ROS generation and alleviate the insulin resistance induced by Cr(VI) treatment. In addition, Cr(VI) treatment induced endoplasmic reticulum (ER) stress and JNK activation and these effects were diminished by N-acetylcysteine. These results suggested that ROS generation through Cr(VI) treatment cause ER stress, JNK activation and insulin resistance in adipocytes. Therefore, the oxidative stress could be a potential interventional target for insulin-resistance related diseases.
C1 [Ge, Xuemei; Liu, Zhen; Qi, Wei; Shi, Xianglin; Zhai, Qiwei] Chinese Acad Sci, Key Lab Nutr & Metab, Shanghai Inst Biol Sci, Inst Nutr Sci,Grad Sch, Shanghai 200031, Peoples R China.
C3 Chinese Academy of Sciences
RP Zhai, QW (corresponding author), Chinese Acad Sci, Key Lab Nutr & Metab, Shanghai Inst Biol Sci, Inst Nutr Sci,Grad Sch, 294 Taiyuan Rd, Shanghai 200031, Peoples R China.
EM qwzhai@sibs.ac.cn
RI Shi, Xianglin/B-8588-2012
OI Zhai, Qiwei/0000-0002-9617-7403
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NR 47
TC 11
Z9 11
U1 0
U2 6
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 1071-5762
EI 1029-2470
J9 FREE RADICAL RES
JI Free Radic. Res.
PY 2008
VL 42
IS 6
BP 554
EP 563
DI 10.1080/10715760802155113
PG 10
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 317XV
UT WOS:000257054600003
PM 18569013
DA 2025-06-11
ER

PT J
AU Lejawa, M
   Osadnik, K
   Osadnik, T
   Pawlas, N
AF Lejawa, Mateusz
   Osadnik, Kamila
   Osadnik, Tadeusz
   Pawlas, Natalia
TI Association of Metabolically Healthy and Unhealthy Obesity Phenotypes
   with Oxidative Stress Parameters and Telomere Length in Healthy Young
   Adult Men. Analysis of the MAGNETIC Study
SO ANTIOXIDANTS
LA English
DT Article
DE metabolically healthy obesity; metabolically unhealthy obesity;
   oxidative stress; telomere length
ID CARDIOVASCULAR-DISEASE; DIABETIC COMPLICATIONS; INSULIN-RESISTANCE;
   PERSPECTIVE; ANTIOXIDANT; MECHANISM; WEIGHT; PLASMA; IMPACT; WOMEN
AB Obesity is a significant factor related to metabolic disturbances that can lead to metabolic syndrome (MetS). Metabolic dysregulation causes oxidative stress, which affects telomere structure. The current study aimed to evaluate the relationships between telomere length, oxidative stress and the metabolically healthy and unhealthy phenotypes in healthy young men. Ninety-eight participants were included in the study (49 healthy slim and 49 obese patients). Study participants were divided into three subgroups according to body mass index and metabolic health. Selected oxidative stress markers were measured in serum. Relative telomere length (rTL) was measured using quantitative polymerase chain reaction. The analysis showed associations between laboratory markers, oxidative stress markers and rTL in metabolically healthy and unhealthy participants. Total oxidation status (TOS), total antioxidant capacity (TAC) and rTL were significantly connected with metabolically unhealthy obesity. TAC was associated with metabolically healthy obesity. Telomeres shorten in patients with metabolic dysregulation related to oxidative stress and obesity linked to MetS. Further studies among young metabolically healthy and unhealthy individuals are needed to determine the pathways related to metabolic disturbances that cause oxidative stress that leads to MetS.
C1 [Lejawa, Mateusz; Osadnik, Kamila; Osadnik, Tadeusz; Pawlas, Natalia] Fac Med Sci Zabrze, Dept Pharmacol, Jordana 38, PL-41808 Zabrze, Poland.
   [Lejawa, Mateusz; Osadnik, Kamila; Osadnik, Tadeusz; Pawlas, Natalia] Med Univ Silesia, PL-40055 Katowice, Poland.
   [Osadnik, Tadeusz] Silesian Ctr Heart Dis, Dept Cardiol & Angiol 2, Marii Sklodowskiej Curie 9, PL-41800 Zabrze, Poland.
C3 Medical University of Silesia; Silesian Center for Heart Diseases
RP Lejawa, M (corresponding author), Fac Med Sci Zabrze, Dept Pharmacol, Jordana 38, PL-41808 Zabrze, Poland.; Lejawa, M (corresponding author), Med Univ Silesia, PL-40055 Katowice, Poland.
EM mateusz.lejawa@sum.edu.pl; kosadnik@sum.edu.pl;
   tadeusz.osadnik@sum.edu.pl; natalia.pawlas@sum.edu.pl
RI ; Osadnik, Tadeusz/P-5844-2014; Pawlas, Natalia/H-5796-2013
OI Lejawa, Mateusz/0000-0002-1228-7534; Osadnik,
   Tadeusz/0000-0002-3202-6972; Osadnik, Kamila/0000-0002-4618-9844;
   Pawlas, Natalia/0000-0002-7551-9371
FU National Science Centre [UMO-2014113IBINZ5/03166]; Medical University of
   Silesia [KNW-1-039/N/8/K]
FX The study was supported by the National Science Centre (Grant No.
   UMO-2014113IBINZ5/03166, OPUS 7) and Medical University of Silesia
   (Grant No. KNW-1-039/N/8/K).
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NR 72
TC 22
Z9 24
U1 3
U2 19
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD JAN
PY 2021
VL 10
IS 1
AR 93
DI 10.3390/antiox10010093
PG 16
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA PX1XW
UT WOS:000611156800001
PM 33440881
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Kaneko, M
   Imaizumi, K
   Saito, A
   Kanemoto, S
   Asada, R
   Matsuhisa, K
   Ohtake, Y
AF Kaneko, Masayuki
   Imaizumi, Kazunori
   Saito, Atsushi
   Kanemoto, Soshi
   Asada, Rie
   Matsuhisa, Koji
   Ohtake, Yosuke
TI ER Stress and Disease: Toward Prevention and Treatment
SO BIOLOGICAL & PHARMACEUTICAL BULLETIN
LA English
DT Review
DE endoplasmic reticulum stress; unfolded protein response;
   neurodegenerative disease; diabetes; metabolic syndrome; cancer
ID ENDOPLASMIC-RETICULUM STRESS; UNFOLDED-PROTEIN RESPONSE; BETA-CELL
   FAILURE; MESSENGER-RNA; TRANSLATIONAL CONTROL; TRANSCRIPTION FACTOR;
   GLUCOSE-HOMEOSTASIS; HEPATIC STEATOSIS; MAMMALIAN-CELLS; AMYLOID-BETA
AB Secretory and membrane proteins are synthesized in ribosomes, then mature in the endoplasmic reticulum (ER), but if ER function is impaired, immature defective proteins accumulate in the ER. This situation is. called ER stress: in response, a defensive mechanism called the unfolded protein response (UPR) is activated in cells to reduce the defective proteins. During the UPR, the ER transmembrane sensor molecules inositol-requiring enzyme 1 (IRE1), activating transcription factor 6 (ATF6), and RNA-dependent protein kinase (PKR)-like ER kinase (PERK) are activated, stress signals are transduced to the outside of the ER, and various cell responses, including gene induction, occur. In ER-associated degradation (ERAD), one type of UPR, defective proteins are eventually expelled from the ER and degraded in the cytoplasm through the ubiquitin proteasome system. Since ER stress has been reported to have relationships with neurodegenerative diseases, diabetes, metabolic syndromes, and cancer, it is the focus of increased attention from the perspectives of elucidating pathogenic mechanisms, and in the development of therapeutics.
C1 [Kaneko, Masayuki; Imaizumi, Kazunori; Kanemoto, Soshi; Asada, Rie; Ohtake, Yosuke] Hiroshima Univ, Inst Biomed & Hlth Sci, Dept Biochem, Minami Ku, 1-2-3 Kasumi, Hiroshima 7348553, Japan.
   [Saito, Atsushi; Matsuhisa, Koji] Hiroshima Univ, Inst Biomed & Hlth Sci, Dept Stress Prot Proc, Minami Ku, 1-2-3 Kasumi, Hiroshima 7348553, Japan.
C3 Hiroshima University; Hiroshima University
RP Kaneko, M (corresponding author), Hiroshima Univ, Inst Biomed & Hlth Sci, Dept Biochem, Minami Ku, 1-2-3 Kasumi, Hiroshima 7348553, Japan.
EM mkaneko@hiroshima-u.ac.jp
RI 幸司, 松久/KGM-0809-2024; Kaneko, Masayuki/F-9302-2011; Saito,
   Atsushi/JQV-6748-2023
OI Kaneko, Masayuki/0000-0002-0477-0171; Matsuhisa,
   Koji/0000-0003-0707-9025; saito, atsushi/0000-0003-2425-3371
FU Grants-in-Aid for Scientific Research [17K15599] Funding Source: KAKEN
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NR 50
TC 100
Z9 107
U1 1
U2 19
PU PHARMACEUTICAL SOC JAPAN
PI TOKYO
PA 2-12-15 SHIBUYA, SHIBUYA-KU, TOKYO, 150-0002, JAPAN
SN 0918-6158
J9 BIOL PHARM BULL
JI Biol. Pharm. Bull.
PD SEP
PY 2017
VL 40
IS 9
BP 1337
EP 1343
DI 10.1248/bpb.b17-00342
PG 7
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA FF6WB
UT WOS:000409156600001
PM 28867719
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Yi, MCL
   Cisneros, LC
   Cho, EJ
   Alexander, M
   Kimelman, FA
   Swentek, L
   Ferrey, A
   Tantisattamo, E
   Ichii, H
AF Yi, Michelle
   Cruz Cisneros, Leslie
   Cho, Eric J.
   Alexander, Michael
   Kimelman, Francesca A.
   Swentek, Lourdes
   Ferrey, Antoney
   Tantisattamo, Ekamol
   Ichii, Hirohito
TI Nrf2 Pathway and Oxidative Stress as a Common Target for Treatment of
   Diabetes and Its Comorbidities
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE diabetes; heart; kidney; liver; oxidative stress; Nrf2
ID STIMULATED LIPOPROTEIN RECEPTOR; IMPAIRED GLUCOSE-TOLERANCE; OXYGEN
   SPECIES PRODUCTION; FATTY LIVER-DISEASE; DIASTOLIC DYSFUNCTION;
   MITOCHONDRIAL SUPEROXIDE; MYOCARDIAL-INFARCTION; ALCOHOL-CONSUMPTION;
   THERAPEUTIC TARGET; METABOLIC SYNDROME
AB Diabetes is a chronic disease that induces many comorbidities, including cardiovascular disease, nephropathy, and liver damage. Many mechanisms have been suggested as to how diabetes leads to these comorbidities, of which increased oxidative stress in diabetic patients has been strongly implicated. Limited knowledge of antioxidative antidiabetic drugs and substances that can address diabetic comorbidities through the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway calls for detailed investigation. This review will describe how diabetes increases oxidative stress, the general impact of that oxidative stress, and how oxidative stress primarily contributes to diabetic comorbidities. It will also address how treatments for diabetes, especially focusing on their effects on the Nrf2 antioxidative pathway, have been shown to similarly affect the Nrf2 pathway of the heart, kidney, and liver systems. This review demonstrates that the Nrf2 pathway is a common pathogenic component of diabetes and its associated comorbidities, potentially identifying this pathway as a target to guide future treatments.
C1 [Yi, Michelle; Cruz Cisneros, Leslie; Cho, Eric J.; Alexander, Michael; Kimelman, Francesca A.; Swentek, Lourdes; Ichii, Hirohito] Univ Calif Irvine, Dept Surg, Irvine, CA 92697 USA.
   [Ferrey, Antoney; Tantisattamo, Ekamol] Univ Calif Irvine, Dept Med, Irvine, CA 92697 USA.
C3 University of California System; University of California Irvine;
   University of California System; University of California Irvine
RP Ichii, H (corresponding author), Univ Calif Irvine, Dept Surg, Irvine, CA 92697 USA.
EM myi10@hs.uci.edu; lcruzcis@hs.uci.edu; ejcho5@hs.uci.edu;
   michaela@hs.uci.edu; fkimelma@hs.uci.edu; lyrobles@hs.uci.edu;
   ferreya@hs.uci.edu; etantisa@hs.uci.edu; hichii@hs.uci.edu
RI Ichii, Hirohito/AAV-8256-2021
OI Yi, Michelle/0009-0007-7278-2661; Kimelman,
   Francesca/0009-0003-6639-1024; Tantisattamo, Ekamol/0000-0003-0883-6892
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NR 149
TC 18
Z9 20
U1 3
U2 22
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD JAN
PY 2024
VL 25
IS 2
AR 821
DI 10.3390/ijms25020821
PG 21
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA GF7O5
UT WOS:001151318200001
PM 38255895
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU D'Alonzo, KT
   Munet-Vilaro, F
   Carmody, DP
   Guarnaccia, PJ
   Linn, AM
   Garsman, L
AF D'Alonzo, Karen Therese
   Munet-Vilaro, Frances
   Carmody, Dennis P.
   Guarnaccia, Peter J.
   Linn, Anne Marie
   Garsman, Lisa
TI Acculturation stress and allostatic load among Mexican immigrant women
SO REVISTA LATINO-AMERICANA DE ENFERMAGEM
LA English
DT Review
DE Allostasis; Acculturation; Obesity; Immigrants; Metabolic Syndrome;
   Case-Control Study
ID HEALTH
AB Objectives: this case-control study compared levels of stress and allostatic load (AL) among Mexican women in the US (n = 19) and Mexico (n = 40). Method: measures of stress included the Perceived Stress Scale (PSS) and the Hispanic Women's Social Stressor Scale (HWSSS). A composite measure of 8 indicators of AL (systolic and diastolic blood pressure, body mass index (BMI), waist-to-hip ratio, total cholesterol, glycated hemoglobin (hemoglobin A1C), triglycerides and C-reactive protein) was calculated. Results: there were no significant group differences in AL between Mexican and Mexican immigrant women (t = 1.55, p = .126). A principal component factor analysis was conducted on the 8 AL indicators; a 2-factor solution explained 57% of the variance. Group differences in the two AL factors were analyzed using MANOVA. BMI and waist-to-hip ratios were lower, but blood pressure and triglycerides were higher in the US group and were mediated by time in the US. Greater acculturation stress was significantly related to increased waist-to-hip ratio (r = .57, p = .02). Final remarks: findings suggest some measures of AL increased with time in the US, and acculturation stress may be a significant factor.
C1 [D'Alonzo, Karen Therese; Carmody, Dennis P.; Linn, Anne Marie] Rutgers State Univ, Sch Nursing, Newark, NJ 07102 USA.
   [Munet-Vilaro, Frances] Calif State Univ Monterey Bay, Dept Nursing, Seaside, CA USA.
   [Guarnaccia, Peter J.] Rutgers State Univ, Dept Human Ecol, New Brunswick, NJ USA.
   [Garsman, Lisa] St Peters Univ, Sch Nursing, Jersey City, NJ USA.
C3 Rutgers University System; Rutgers University New Brunswick; Rutgers
   University Newark; California State University System; California State
   University Monterey Bay; Rutgers University System; Rutgers University
   New Brunswick
RP D'Alonzo, KT (corresponding author), Rutgers State Univ, Sch Nursing, Newark, NJ 07102 USA.
EM kdalonzo@sn.rutgers.edu
RI D'Alonzo, Karen/GSM-6563-2022; Carmody, Dennis/AAS-7734-2020
OI Garsman, Lisa/0000-0001-6598-255X; Linn, Anne/0000-0001-9720-2378;
   Carmody, Dennis/0000-0002-1288-104X; Munet-Vilaro,
   Frances/0000-0002-3049-238X
FU International Collaborative Research Grant from The Centers for Global
   Advancement and International Affairs (GAIA Centers) at Rutgers, the
   State University of New Jersey, USA
FX Supported by International Collaborative Research Grant from The Centers
   for Global Advancement and International Affairs (GAIA Centers) at
   Rutgers, the State University of New Jersey, USA.
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Z9 14
U1 0
U2 8
PU UNIV SAO PAULO, ESCOLA DE ENFERMAGEM DE RIBEIRAO PRETO
PI RIBEIRAO PRETO
PA AV BANDEIRANTES, 3900, RIBEIRAO PRETO, SP 14040-902  A, BRAZIL
SN 1518-8345
J9 REV LAT-AM ENFERM
JI Rev. Latino-Am. Enfermagem
PY 2019
VL 27
AR e3135
DI 10.1590/1518-8345.2578.3135
PG 11
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA HY7IQ
UT WOS:000468308600001
PM 31038629
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Raygan, F
   Rezavandi, Z
   Tehrani, SD
   Farrokhian, A
   Asemi, Z
AF Raygan, Fariba
   Rezavandi, Zohreh
   Tehrani, Sahar Dadkhah
   Farrokhian, Alireza
   Asemi, Zatollah
TI The effects of coenzyme Q10 administration on glucose homeostasis
   parameters, lipid profiles, biomarkers of inflammation and oxidative
   stress in patients with metabolic syndrome (Publication with Expression
   of Concern)
SO EUROPEAN JOURNAL OF NUTRITION
LA English
DT Article; Publication with Expression of Concern
DE Coenzyme Q10; Supplementation; Metabolic syndrome; Type 2 diabetes
   mellitus; Coronary heart disease
ID Q(10) SUPPLEMENTATION; INSULIN-RESISTANCE; GLYCEMIC CONTROL; PLASMA;
   DISEASE; ARTERY; INTERLEUKIN-6; DYSFUNCTION; INDEXES
AB Limited data are available indicating the effects of coenzyme Q10 (CoQ10) supplementation on metabolic status of patients with metabolic syndrome (MetS).
   The present study was conducted to determine the effects of CoQ10 administration on glucose homeostasis parameters, lipid profiles, biomarkers of inflammation and oxidative stress among patients with MetS.
   This randomized, double-blind, placebo-controlled trial was performed among 60 overweight or obese and type 2 diabetes mellitus patients with coronary heart disease aged 40-85 years old. Participants were randomly allocated into two groups. Group A (n = 30) received 100 mg CoQ10 supplements and group B (n = 30) received placebo for 8 weeks. Fasting blood samples were taken at the beginning of the study and after 8-week intervention to quantify glucose homeostasis parameters, lipid profiles and biomarkers of inflammation and oxidative stress.
   Compared with the placebo, CoQ10 supplementation resulted in a significant reduction in serum insulin levels (-2.1 +/- A 7.1 vs. +4.1 +/- A 7.8 A mu IU/mL, P = 0.002) and homeostasis model of assessment-insulin resistance (-0.7 +/- A 2.1 vs. +1.0 +/- A 2.0, P = 0.002) and homeostatic model assessment-beta cell function (-5.9 +/- A 22.2 vs. +15.9 +/- A 34.0, P = 0.005). In addition, patients who received CoQ10 supplements had a significant increase in plasma total antioxidant capacity (TAC) concentrations (+26.0 +/- A 105.0 vs. -162.2 +/- A 361.8 mmol/L, P = 0.008) compared with the placebo group. However, after adjustment for the baseline levels, age and baseline BMI, the effect on TAC levels (P = 0.08) disappeared. Additionally, compared with the placebo group, a significant positive trends in plasma glutathione (P = 0.06) and a significant reduction in malondialdehyde (P = 0.08) were seen among patients who received CoQ10 supplement. We did not observe any significant changes in fasting plasma glucose, lipid concentrations and inflammatory markers.
   Overall, daily intake of 100 mg CoQ10 supplements among patients with MetS for 8 weeks had beneficial effects on serum insulin levels, HOMA-IR, HOMA-B and plasma TAC concentrations.
   www.irct.ir http://www.irct.ir" TargetType="URL" IRCT201502245623N35.
C1 [Raygan, Fariba; Rezavandi, Zohreh; Farrokhian, Alireza] Kashan Univ Med Sci, Sch Med, Dept Cardiol, Kashan, Iran.
   [Tehrani, Sahar Dadkhah; Asemi, Zatollah] Kashan Univ Med Sci, Res Ctr Biochem & Nutr Metab Dis, Kashan, Iran.
RP Asemi, Z (corresponding author), Kashan Univ Med Sci, Res Ctr Biochem & Nutr Metab Dis, Kashan, Iran.
EM asemi_r@yahoo.com
RI Raygan, Fariba/W-3349-2017; asemi, zatollah/J-2677-2018; Asemi,
   Zatollah/G-7393-2017; Farrokhian, Alireza/G-8864-2017
OI Asemi, Zatollah/0000-0001-5265-4792; Raygan, Fariba/0000-0003-3789-5584;
   Dadkhah Tehrani, Sahar/0009-0002-3264-8840; Farrokhian,
   Alireza/0000-0002-7814-5539
FU KUMS, Iran
FX The current study was founded by a grant from the Vice-chancellor for
   Research, KUMS, Iran. The authors would like to thank the staff of
   Naghavi Clinic (Kashan, Iran) for their assistance in this project.
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NR 33
TC 69
Z9 70
U1 0
U2 12
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1436-6207
EI 1436-6215
J9 EUR J NUTR
JI Eur. J. Nutr.
PD DEC
PY 2016
VL 55
IS 8
BP 2357
EP 2364
DI 10.1007/s00394-015-1042-7
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA ED6NY
UT WOS:000388973500003
PM 26385228
DA 2025-06-11
ER

PT J
AU Dimova, LG
   Battista, S
   Plösch, T
   Kampen, RA
   Liu, F
   Verkaik-Schakel, RN
   Pratico, D
   Verkade, HJ
   Tietge, UJF
AF Dimova, Lidiya G.
   Battista, Simone
   Plosch, Torsten
   Kampen, Rosalie A.
   Liu, Fan
   Verkaik-Schakel, Rikst Nynke
   Pratico, Domenico
   Verkade, Henkjan J.
   Tietge, Uwe J. F.
TI Gestational oxidative stress protects against adult obesity and insulin
   resistance
SO REDOX BIOLOGY
LA English
DT Article
DE Fetal oxidative stress; Mitohormesis; Metabolic programming; Adiposity;
   Epigenetics; Methylation
ID CHOLESTEROL; MOUSE; GENE; EXPRESSION; ORIGINS; GLUCOSE; FETAL; MICE;
   CELL
AB Pregnancy complications such as preeclampsia cause increased fetal oxidative stress and fetal growth restriction, and associate with a higher incidence of adult metabolic syndrome. However, the pathophysiological contribution of oxidative stress per se is experimentally difficult to discern and has not been investigated. This study determined, if increased intrauterine oxidative stress (IUOx) affects adiposity, glucose and cholesterol metabolism in adult Ldlr-/-xSod2+/+ offspring from crossing male Ldlr-/-xSod2+/+ mice with Ldlr-/-xSod2+/- dams (IUOx) or Ldlr-/-xSod2+/- males with Ldlr-/-xSod2+/+ dams (control). At 12 weeks of age mice received Western diet for an additional 12 weeks. Adult male IUOx offspring displayed lower body weight and reduced adiposity associated with improved glucose tolerance compared to controls. Reduced weight gain in IUOx was conceivably due to increased energy dissipation in white adipose tissue conveyed by higher expression of Ucp1 and an accompanying decrease in DNA methylation in the Ucp1 enhancer region. Female offspring did not show comparable phenotypes. These results demonstrate that fetal oxidative stress protects against the obesogenic effects of Western diet in adulthood by programming energy dissipation in white adipose tissue at the level of Ucp1.
C1 [Dimova, Lidiya G.; Battista, Simone; Kampen, Rosalie A.; Liu, Fan; Verkade, Henkjan J.; Tietge, Uwe J. F.] Univ Groningen, Univ Med Ctr Groningen, Dept Pediat, Hanzepl 1, Groningen, Netherlands.
   [Plosch, Torsten; Verkaik-Schakel, Rikst Nynke] Univ Groningen, Univ Med Ctr Groningen, Dept Obstet & Gynecol, Hanzepl 1, Groningen, Netherlands.
   [Pratico, Domenico] Temple Univ, Lewis Katz Sch Med, Alzheimers Ctr Temple, 3500 N Broad St, Philadelphia, PA 19122 USA.
   [Liu, Fan; Tietge, Uwe J. F.] Karolinska Inst, Dept Lab Med, Div Clin Chem, Alfred Nobels Alle 8, Stockholm, Sweden.
   [Tietge, Uwe J. F.] Karolinska Univ Hosp, Karolinska Univ Lab, Clin Chem, Stockholm, Sweden.
C3 University of Groningen; University of Groningen; Pennsylvania
   Commonwealth System of Higher Education (PCSHE); Temple University;
   Karolinska Institutet; Karolinska Institutet; Karolinska University
   Hospital
RP Tietge, UJF (corresponding author), Karolinska Inst, Dept Lab Med LABMED, Div Clin Chem, H5,Alfred Nobels Alle 8, S-14183 Stockholm, Sweden.
EM u_tietge@yahoo.com
RI Liu, Fan/B-8833-2013; Plösch, Torsten/X-6808-2019; Pratico,
   Domenico/ABA-9590-2020; Dimova, Lidiya/E-3224-2017
OI Verkade, Henkjan J/0000-0002-7034-2861; Liu, Fan/0000-0001-9647-6705;
   Dimova, Lidiya/0000-0002-7387-4564
FU Dutch Technology Foundation STW [11675]; Danone Nutricia Research
FX This work was supported by the Dutch Technology Foundation STW
   (www.stw.nl, grant: 11675) and was partly funded by Danone Nutricia
   Research. STW is now part of the Netherlands Organisation for Scientific
   Research.
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NR 27
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U2 7
PU ELSEVIER
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PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
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J9 REDOX BIOL
JI Redox Biol.
PD JAN
PY 2020
VL 28
AR 101329
DI 10.1016/j.redox.2019.101329
PG 6
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA JU2FG
UT WOS:000501490700033
PM 31550664
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Rafiei, H
   Omidian, K
   Bandy, B
AF Rafiei, Hossein
   Omidian, Kosar
   Bandy, Brian
TI Protection by different classes of dietary polyphenols against palmitic
   acid-induced steatosis, nitro-oxidative stress and endoplasmic reticulum
   stress in HepG2 hepatocytes
SO JOURNAL OF FUNCTIONAL FOODS
LA English
DT Article
DE Non-alcoholic fatty liver disease; Functional food polyphenols;
   Endoplasmic reticulum stress; Oxidative stress; Mitochondrial
   dysfunction
ID FATTY LIVER-DISEASE; NF-KAPPA-B; MITOCHONDRIAL DYSFUNCTION; GREEN TEA;
   CHEMICAL CHAPERONES; INSULIN-RESISTANCE; GLUCOSE-HOMEOSTASIS;
   LIPID-ACCUMULATION; METABOLIC SYNDROME; HEPATIC STEATOSIS
AB Polyphenol-rich functional foods have shown promise in ameliorating NAFLD but the relative effectiveness and mechanisms of different polyphenols are largely unknown. In a model of steatosis using HepG2 hepatocytes exposed to palmitic acid, we investigated the effect of selected polyphenols (resveratrol, quercetin, catechin, cyanidin, kuromanin) and berberine. Exposure to palmitic acid produced steatosis and intracellular ROS production, which were prevented by all of the polyphenols and berberine, at 10 mu M. Palmitic acid produced a 245% increase in mRNA for inducible nitric oxide synthase (iNOS) that was almost completely prevented by all of the polyphenols (but not by berberine). Most of the polyphenols also partially inhibited palmitic acid-induced increases in markers of endoplasmic reticulum stress, and decreases in mitochondrial content and mitochondrial membrane potential. In conclusion, the polyphenols all similarly prevented steatosis, ROS generation and iNOS induction, and protected against ER stress and mitochondrial impairment.
C1 [Rafiei, Hossein; Omidian, Kosar; Bandy, Brian] Univ Saskatchewan, Nutr Div, Coll Pharm & Nutr, Saskatoon, SK, Canada.
C3 University of Saskatchewan
RP Bandy, B (corresponding author), 107 Wiggins Rd, Saskatoon, SK S7N 5E5, Canada.
EM b.bandy@usask.ca
RI Rafiei, Hossein/W-4825-2017
OI Rafiei, Hossein/0000-0002-4843-9261
FU Saskatchewan Health Research Foundation (SHRF); College of Pharmacy and
   Nutrition; University of Saskatchewan
FX This work was financed by a grant from the Saskatchewan Health Research
   Foundation (SHRF). Scholarships to HR and KO were provided by the
   College of Pharmacy and Nutrition and the University of Saskatchewan.
   H.R and B.B designed the research; H.R and K.O conducted the research;
   H.R analyzed the data and performed the statistical analyses; H.R wrote
   the manuscript; and B.B had primary responsibility for the final
   content. All authors read and approved the final manuscript.
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NR 85
TC 19
Z9 21
U1 2
U2 76
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1756-4646
J9 J FUNCT FOODS
JI J. Funct. Food.
PD MAY
PY 2018
VL 44
BP 173
EP 182
DI 10.1016/j.jff.2018.02.033
PG 10
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA GC8GE
UT WOS:000430030900021
DA 2025-06-11
ER

PT J
AU Sepanjnia, K
   Modabbernia, A
   Ashrafi, M
   Modabbernia, MJ
   Akhondzadeh, S
AF Sepanjnia, Khatereh
   Modabbernia, Amirhossein
   Ashrafi, Mandana
   Modabbernia, Mohammad-Jafar
   Akhondzadeh, Shahin
TI Pioglitazone Adjunctive Therapy for Moderate-to-Severe Major Depressive
   Disorder: Randomized Double-Blind Placebo-Controlled Trial
SO NEUROPSYCHOPHARMACOLOGY
LA English
DT Article
DE PPAR-gamma; pioglitazone; major depressive disorder; adjunctive therapy;
   thiazolidinedione; randomized controlled trial
ID PPAR-GAMMA; CLINICAL-TRIAL; ADD-ON; RECEPTOR; ROSIGLITAZONE; OUTCOMES;
   STRESS; BRAIN; NEUROINFLAMMATION; AUGMENTATION
AB Thiazolidinediones have shown antidepressant effect in animal studies, as well as in some uncontrolled studies evaluating human subjects with concurrent major depressive disorder (MDD) and metabolic syndrome. Although these drugs are insulin sensitizers, they also have important anti-inflammatory, neuroprotective, and anti-excitotoxic properties. Thus, we hypothesized that they would show antidepressant effect in patients with MDD even if it was not accompanied by metabolic disturbances. In this double-blind placebo-controlled study, 40 patients with MDD (DSM-IV-TR) and Hamilton depression rating scale-17 (Ham-D) score >= 22 were randomized to citalopram plus pioglitazone (15 mg every 12 h) (n = 20) or citalopram plus placebo (n 20) for 6 weeks. Patients were evaluated using Ham-D (weeks 0, 2, 4, 6). Repeated-measure analysis of variance (ANOVA) and analysis of covariance were used for comparison of scores between the two groups. Treatment response (>= 50% reduction in Ham-D score), remission (Ham-D score <= 7), and early improvement (>= 20% reduction in Ham-D score within the first 2 weeks) were compared between the two groups using Fisher's exact test. Pioglitazone showed superiority over placebo during the course of the trial (F(1, 38) = 9.483, p = 0.004). Patients in the pioglitazone group had significantly lower scores at all time points than the placebo group (P<0.01). Frequency of early improvement, response (week 6), and remission was significantly higher in the pioglitazone group (95%, 95%, 45%, respectively) than in the placebo (30%, 40%, 15% respectively) group (P<0.001, <0.001, 0.04, respectively). Frequency of side effects was similar between the two groups. Pioglitazone is a safe and effective adjunctive short-term treatment in patients with moderate-to-severe MDD even in the absence of metabolic syndrome and diabetes (http://clinicaltrials.gov/ct2/show/NCT01109030). Neuropsychopharmacology (2012) 37, 2093-2100; doi:10.1038/npp.2012.58; published online 2 May 2012
C1 [Sepanjnia, Khatereh; Modabbernia, Amirhossein; Ashrafi, Mandana; Akhondzadeh, Shahin] Univ Tehran Med Sci, Roozbeh Psychiat Hosp, Psychiat Res Ctr, Tehran 13337, Iran.
   [Modabbernia, Mohammad-Jafar] Guilan Univ Med Sci, Dept Psychiat, Guilan, Iran.
C3 Tehran University of Medical Sciences; Guilan University of Medical
   Sciences
RP Akhondzadeh, S (corresponding author), Univ Tehran Med Sci, Roozbeh Psychiat Hosp, Psychiat Res Ctr, S Kargar St, Tehran 13337, Iran.
EM s.akhond@neda.net
RI Modabbernia, Amirhossein/H-3709-2014; Akhondzadeh, Shahin/F-2914-2018
OI Akhondzadeh, Shahin/0000-0002-2277-5101
FU Tehran University of Medical Sciences [9476]
FX This study was Dr Khatereh Sepanjnia's postgraduate thesis toward
   qualification for the Iranian Board of Psychiatry under the supervision
   of Prof. Shahin Akhondzadeh. This study was supported by a grant from
   Tehran University of Medical Sciences to Prof. Shahin Akhondzadeh (Grant
   No. 9476).
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NR 45
TC 119
Z9 127
U1 0
U2 16
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0893-133X
EI 1740-634X
J9 NEUROPSYCHOPHARMACOL
JI Neuropsychopharmacology
PD AUG
PY 2012
VL 37
IS 9
BP 2093
EP 2100
DI 10.1038/npp.2012.58
PG 8
WC Neurosciences; Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA 975FY
UT WOS:000306494600012
PM 22549115
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Jung, UJ
AF Jung, Un Ju
TI Sarcopenic Obesity: Involvement of Oxidative Stress and Beneficial Role
   of Antioxidant Flavonoids
SO ANTIOXIDANTS
LA English
DT Review
DE sarcopenic obesity; pathophysiology; oxidative stress; flavonoids
ID ENDOPLASMIC-RETICULUM STRESS; ACTIVATED PROTEIN-KINASE; SKELETAL-MUSCLE
   ATROPHY; DIET-INDUCED OBESITY; ONION PEEL EXTRACT; NF-KAPPA-B;
   MITOCHONDRIAL DYSFUNCTION; MOLECULAR-MECHANISMS; ADIPOSE-TISSUE; ER
   STRESS
AB Sarcopenic obesity, which refers to concurrent sarcopenia and obesity, is characterized by decreased muscle mass, strength, and performance along with abnormally excessive fat mass. Sarcopenic obesity has received considerable attention as a major health threat in older people. However, it has recently become a health problem in the general population. Sarcopenic obesity is a major risk factor for metabolic syndrome and other complications such as osteoarthritis, osteoporosis, liver disease, lung disease, renal disease, mental disease and functional disability. The pathogenesis of sarcopenic obesity is multifactorial and complicated, and it is caused by insulin resistance, inflammation, hormonal changes, decreased physical activity, poor diet and aging. Oxidative stress is a core mechanism underlying sarcopenic obesity. Some evidence indicates a protective role of antioxidant flavonoids in sarcopenic obesity, although the precise mechanisms remain unclear. This review summarizes the general characteristics and pathophysiology of sarcopenic obesity and focuses on the role of oxidative stress in sarcopenic obesity. The potential benefits of flavonoids in sarcopenic obesity have also been discussed.
C1 [Jung, Un Ju] Pukyong Natl Univ, Dept Food Sci & Nutr, 45 Yongso ro, Busan 48513, South Korea.
C3 Pukyong National University
RP Jung, UJ (corresponding author), Pukyong Natl Univ, Dept Food Sci & Nutr, 45 Yongso ro, Busan 48513, South Korea.
EM jungunju@naver.com
OI Jung, Un Ju/0000-0002-5441-460X
FU National Research Foundation of Korea (NRF) - Korea government
   [NRF-2017R1A2B4002675, 2019R1F1A1059945]
FX This research was supported by the National Research Foundation of Korea
   (NRF) grant funded by the Korea government, grant number
   NRF-2017R1A2B4002675 and 2019R1F1A1059945.
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NR 272
TC 17
Z9 17
U1 17
U2 41
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD MAY 8
PY 2023
VL 12
IS 5
AR 1063
DI 10.3390/antiox12051063
PG 25
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA H2GE5
UT WOS:000994192600001
PM 37237929
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Ma, LH
   Jiang, XL
   Wang, S
   Ning, J
AF Ma, Lihua
   Jiang, Xiaolian
   Wang, Song
   Ning, Jiang
TI Application of health self-management intervention program for metabolic
   syndrome patients in the bereaved population following the Wenchuan
   earthquake
SO FRONTIERS IN PUBLIC HEALTH
LA English
DT Article
DE metabolic syndrome; bereavement; self-management; intervention; RCT -
   randomized controlled trial
ID RISK
AB Background: The destructive Wenchuan earthquake has led to approximately 800,000 people being bereaved. In the previous cross-sectional study, we explored the long-term incidence of Metabolic Syndrome (MS) and studied its influencing factors among the bereaved population 12 years after the Wenchuan earthquake. Chronic disease self-management has become a recognized public health service. Studies have shown that demographic and genetic factors, stress, geographical environment, society, culture, dietary habits, lifestyle, and other aspects influence MS. Due to the Wenchuan earthquake being a serious stress event, the implementation of targeted interventions should be discussed further.Objectives: To verify the effect of applying a self-management intervention program for patients with MS among the bereaved population following the Wenchuan earthquake.Design: A randomized controlled trial (RCT) design was adopted.Participants: A total of 132 bereaved patients with MS following the Wenchuan earthquake constituted the sample.Methods: The study was based on the Cognitive-Phenomenological-Transaction, Chronic Disease Self-Management Program, and Patient Empowerment Conceptual Model, which combined with the latest evidence-based guidelines, were used to systematically evaluate cross-sectional results of this study that were used to construct a stress management-based health self-management intervention program and MS health self-management manual for bereaved patients with MS following the Wenchuan earthquake. In addition, we revised and completed a health self-management intervention program and health self-management manual for patients with MS by using the expert consultation method. General data were collected prior to intervention (T0). We collected the patients' MS disease-related physiological indicators before intervention (T0), after intervention (T1), and 2 months after intervention (T2). EipData3.1 software was used to input data in duplex and duplicate, and SPSS22.0 software was used for statistical analysis.Results: The variance analysis showed that the total score of healthy self-management behavior and the score of diet management, exercise management, drug management, and emotional management have intergroup effects, time effects, and group-time interaction effects (p < 0.05). When the differences between groups were further compared, we found that the total score and the score of six dimensions (excluding disease self-monitoring management) were higher than those of the control groups at T1 and T2, and the differences were statistically significant (p < 0.05).Conclusion: The intervention program of healthy self-management for patients with MS who come from bereaved families following the Wenchuan earthquake can effectively improve patients' health self-management behaviors.
C1 [Ma, Lihua; Jiang, Xiaolian; Wang, Song; Ning, Jiang] Sichuan Univ, West China Hosp, West China Sch Nursing, Chengdu, Peoples R China.
   [Ma, Lihua] Lanzhou Univ, Hosp 1, Lanzhou, Gansu, Peoples R China.
C3 Sichuan University; Lanzhou University
RP Jiang, XL (corresponding author), Sichuan Univ, West China Hosp, West China Sch Nursing, Chengdu, Peoples R China.
EM jiang_xiaolian@126.com
FU Natural Science Foundation of Gansu Province [21JR1RA106]; National
   Natural Science Foundation of China [72264022]; First Hospital of
   Lanzhou University [ldyyn2022-97]
FX The author(s) declare financial support was received for the research,
   authorship, and/or publication of this article. This research granted
   from the Natural Science Foundation of Gansu Province (No. 21JR1RA106),
   National Natural Science Foundation of China (No.72264022) and the First
   Hospital of Lanzhou University doctoral research start-up fund
   (ldyyn2022-97).
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NR 27
TC 0
Z9 0
U1 2
U2 5
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 2296-2565
J9 FRONT PUBLIC HEALTH
JI Front. Public Health
PD DEC 7
PY 2023
VL 11
AR 1277389
DI 10.3389/fpubh.2023.1277389
PG 15
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA CV0U5
UT WOS:001127902200001
PM 38145081
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Cottone, S
   Lorito, MC
   Riccobene, R
   Nardi, E
   Mulè, G
   Buscemi, S
   Geraci, C
   Guarneri, M
   Arsena, R
   Cerasola, G
AF Cottone, Santina
   Lorito, Maria Carmela
   Riccobene, Raffaella
   Nardi, Emilio
   Mule, Giuseppe
   Buscemi, Silvio
   Geraci, Calogero
   Guarneri, Marco
   Arsena, Rosalia
   Cerasola, Giovanni
TI Oxidative stress, inflammation and cardiovascular disease in chronic
   renal failure
SO JOURNAL OF NEPHROLOGY
LA English
DT Review
DE oxidative stress; endothelium; atherosclerosis; renal failure
ID LEFT-VENTRICULAR HYPERTROPHY; OXIDANT STRESS; KIDNEY-DISEASE;
   ATHEROSCLEROSIS; MORTALITY; ASSOCIATION; DIALYSIS; LIPOPROTEIN;
   DYSFUNCTION; BIOMARKERS
AB Traditional risk factors such as hypertension, diabetes, dyslipidemia, obesity and metabolic syndrome, as well as additional nontraditional risk factors, can damage the kidney directly and by promoting intrarenal atherogenesis. Evidence indicates that increased oxidative stress and inflammation may mediate most of the effects of risk factors on the kidney. Clinical studies have demonstrated a relationship between oxidative stress and inflammatory biomarkers, and a few studies indicate an inverse correlation of oxidative stress biomarkers with estimated glomerular filtration rate (eGFR). Further, surrogate indexes of atherosclerosis such as intima-media thickness and aortic pulse wave velocity have been demonstrated to be related to plasma concentrations of markers of endothelial activation, inflammation and fibrosis in patients with different stages of chronic kidney disease (CKD). Moreover, plasma concentrations of high-sensitivity Creactive protein have been shown to be increased and related to left ventricular mass in CKD individuals having left ventricular hypertrophy. In contrast, in these patients, decreases in fetuin-A plasma levels have been reported. Considering the complex background of the pathophysiological changes characterizing CKD patients, we can consider cardiovascular disease a multifactorial complication of CKD.
C1 [Cottone, Santina; Geraci, Calogero; Guarneri, Marco; Arsena, Rosalia] Univ Palermo, Chair Nephrol, Palermo, Italy.
   [Cottone, Santina; Geraci, Calogero; Guarneri, Marco; Arsena, Rosalia] Univ Palermo, Chair Nephrol, Unit Renal Dis & Hypertens, Palermo, Italy.
   [Lorito, Maria Carmela; Riccobene, Raffaella; Nardi, Emilio; Mule, Giuseppe; Buscemi, Silvio; Cerasola, Giovanni] Univ Palermo, Chair Internal Med, Dept Internal Med, Palermo, Italy.
C3 University of Palermo; University of Palermo; University of Palermo
RP Cottone, S (corresponding author), Via Vespro 129, I-90127 Palermo, Italy.
EM sancott@tin.it
RI Nardi, Emilio/AAB-9614-2022; MULE', GIUSEPPE/AAM-5435-2020; buscemi,
   silvio/K-9662-2016
OI Riccobene, Raffaella/0009-0005-2712-1616; Nardi,
   Emilio/0000-0003-1844-0285; GUARNERI, Marco/0000-0002-0447-6861;
   buscemi, silvio/0000-0003-0730-7649; Mulè&apos;,
   Giuseppe/0000-0002-8705-4911; Mule', Giuseppe/0000-0002-8500-8671;
   cottone, santina/0000-0001-6226-5846
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NR 26
TC 120
Z9 128
U1 1
U2 20
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1121-8428
EI 1724-6059
J9 J NEPHROL
JI J. Nephrol.
PD MAR-APR
PY 2008
VL 21
IS 2
BP 175
EP 179
PG 5
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 317TC
UT WOS:000257041900006
PM 18446711
DA 2025-06-11
ER

PT J
AU Eisenmann, JC
AF Eisenmann, Joey C.
TI Insight into the causes of the recent secular trend in pediatric
   obesity: Common sense does not always prevail for complex,
   multi-factorial phenotypes
SO PREVENTIVE MEDICINE
LA English
DT Review
DE obesity; prenatal environmental; macrosomia; gestational diabetes;
   physical activity; diet
ID BODY-MASS INDEX; PHYSICAL-ACTIVITY; UNITED-STATES; FETAL GROWTH;
   RISK-FACTORS; NEONATAL MACROSOMIA; SEDENTARY BEHAVIOR; METABOLIC
   SYNDROME; BRITISH CHILDREN; TEMPORAL TRENDS
AB Although the secular increase in pediatric obesity is well-documented, there has been no serious attempt to systematically address the causes of this secular trend. The aim of this paper is to provide a better understanding of the possible causes of the recent secular increase in pediatric obesity by reviewing and synthesizing the available literature pertaining to the topic. The paper addresses caveats and important considerations regarding the body mass index, physical activity, and diet and also considers alternative explanations (stress, sleep, maternal health, epigenetic mechanisms) for the secular trend. It is likely that the increased BMI is due to both an increased fat-free mass and fat mass (including waist circumference). Although total caloric intake has remained unchanged, there was a clear trend in increased simple sugar consumption. It is conceivable that total energy expenditure has decreased because of a decline in spontaneous but not voluntary physical activity. Several indicators of psycho-social stress (antidepressant medication prescriptions and suicide attempts, anxiety) have increased along with a decreased sleep duration. Finally, there is intriguing evidence that suggests that the secular trend is related to a common origin in fetal life that is exacerbated by postnatal events/stressors. The insight gained from examining the possible causes of the trend provides a better understanding of the basic etiology of pediatric obesity and should be incorporated into prevention and intervention models. (c) 2006 Elsevier Inc. All rights reserved.
C1 Iowa State Univ, Dept Hlth & Human Performance, Lab Study Growth Maturat & Phys Act, Ames, IA 50011 USA.
C3 Iowa State University
RP Eisenmann, JC (corresponding author), Iowa State Univ, Dept Hlth & Human Performance, Lab Study Growth Maturat & Phys Act, Ames, IA 50011 USA.
EM jce@iastate.edu
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NR 90
TC 68
Z9 82
U1 0
U2 15
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0091-7435
EI 1096-0260
J9 PREV MED
JI Prev. Med.
PD MAY
PY 2006
VL 42
IS 5
BP 329
EP 335
DI 10.1016/j.ypmed.2006.02.002
PG 7
WC Public, Environmental & Occupational Health; Medicine, General &
   Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health; General & Internal Medicine
GA 053GP
UT WOS:000238293900002
PM 16563483
DA 2025-06-11
ER

PT J
AU Qi, KJ
   Zhao, ZT
   Zhang, W
   Yang, F
AF Qi, Kai-Jie
   Zhao, Zhong-Tao
   Zhang, Wen
   Yang, Fang
TI The impacts of vitamin D supplementation in adults with metabolic
   syndrome: A systematic review and meta-analysis of randomized controlled
   trials
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Review
DE vitamin D; metabolic syndrome; randomized controlled trials;
   meta-analysis; inconclusive results
ID POLYCYSTIC-OVARY-SYNDROME; NONALCOHOLIC FATTY LIVER; D DEFICIENCY;
   BLOOD-PRESSURE; DOUBLE-BLIND; CARDIOVASCULAR-DISEASE; INSULIN
   SENSITIVITY; DIABETES-MELLITUS; OXIDATIVE STRESS; GLYCEMIC CONTROL
AB Background: Studies have shown the association of vitamin D status with the development of metabolic syndrome (MetS), which has attracted an extensive research interest with inconsistent results. Therefore, we hypothesized that vitamin D supplementation (VDS) will benefit adults with MetS.Aims: To test our hypothesis, we performed a meta-analysis to evaluate the effect of VDS on MetS in adults using relevant biomarkers such as anthropometric parameters, blood pressure, blood lipid profile, glycemia, oxidative stress and vitamin D toxicity (VDT).Methods: Randomized controlled trials published in PubMed, Web of Science, embase and the Cochrane Library between 2012 and 2022 on the effect of VDS on MetS in adults were searched. The language was limited to English. A meta-analysis performed using RevMan 5.4 and Stata 14.0 software, sensitivity analysis, and evaluation of the risk of bias and general quality of the resulting evidence were conducted.Results: Eventually, 13 articles were included in this meta-analysis. Overall, VDS significantly increased the endline serum 25-hydroxyvitamin D levels as compared to the control [MD:17.41, 95% CI (14.09, 20.73), p < 0.00001]. VDS did not affect waist circumference, body mass index, body fat percentage and VDT biomarkers, but decreased waist-to-hip ratio and blood pressure (p < 0.01). VDS significantly decreased fasting plasma glucose (FPG) [MD: 3.78; 95% CI (-6.52, -1.03), p = 0.007], but did not affect the levels of blood high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), and triglyceride (TG). Pooled estimate of nine papers indicated a significant reduction of fasting insulin (FI) (p = 0.006), and homeostasis model assessment of insulin resistance (p = 0.0001). The quantitative insulin check index levels were moderately increased (p = 0.007) without any impact on the glycosylated hemoglobin type A1C (HbA1c). For the oxidative stress parameters, VDS significantly lowered the levels of malondialdehyde and hypersensitive C-reactive protein (p < 0.05).Conclusion: Results of this meta-analysis demonstrate that VDS only reduces insulin resistance and hypertension but not the blood lipid profile and HbA1c. It appears that the evidence for the benefit of VDS in adults with MetS is inconclusive. Further clinical studies are still needed.
C1 [Qi, Kai-Jie; Zhao, Zhong-Tao; Zhang, Wen; Yang, Fang] Hubei Univ Chinese Med, Sch Lab Med, Wuhan, Peoples R China.
C3 Hubei University of Chinese Medicine
RP Yang, F (corresponding author), Hubei Univ Chinese Med, Sch Lab Med, Wuhan, Peoples R China.
EM fangy521@hbtcm.edu.cn
RI Yang, Fang/JZT-6946-2024; Yang, Fang/J-8466-2017
OI Yang, Fang/0000-0002-7092-2532
FU Scientific Research Plan of Hubei Provincial Health Commission; 
   [WJ2021Q050]
FX Funding The work was supported by the Scientific Research Plan of Hubei
   Provincial Health Commission (Grant number: WJ2021Q050).
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NR 101
TC 19
Z9 19
U1 0
U2 8
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD OCT 5
PY 2022
VL 13
AR 1033026
DI 10.3389/fphar.2022.1033026
PG 23
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 5Q9SM
UT WOS:000874162400001
PM 36278155
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Rodriguez, JS
   Rodríguez-González, GL
   Reyes-Castro, LA
   Ibáñez, C
   Ramírez, A
   Chavira, R
   Larrea, F
   Nathanielsz, PW
   Zambrano, E
AF Rodriguez, J. S.
   Rodriguez-Gonzalez, G. L.
   Reyes-Castro, L. A.
   Ibanez, C.
   Ramirez, A.
   Chavira, R.
   Larrea, F.
   Nathanielsz, P. W.
   Zambrano, E.
TI Maternal obesity in the rat programs male offspring exploratory,
   learning and motivation behavior: prevention by dietary intervention
   pre-gestation or in gestation
SO INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
LA English
DT Article
DE Developmental programming; Cognition; Stress response; Consummatory
   behavior; Corticosterone
ID HIGH-FAT DIET; CHRONIC LUNG-DISEASE; LOW-PROTEIN DIET; JUNK FOOD DIET;
   PRESYNAPTIC TERMINALS; DEVELOPMENTAL ORIGINS; NUTRIENT RESTRICTION;
   METABOLIC SYNDROME; GENE-EXPRESSION; PRENATAL STRESS
AB We studied the effects of maternal high fat diet (HFD, 25% calories from fat administered before and during pregnancy and lactation) and dietary intervention (switching dams from HFD to control diet) at different periconceptional periods on male offspring anxiety related behavior, exploration, learning, and motivation. From weaning at postnatal day (PND) 21, female subjects produced to be the mothers in the study received either control diet (CTR - 5% calories from fat), HFD through pregnancy and lactation (MO), HFD during PNDs 21-90 followed by CTR diet (pre-gestation (PG) intervention) or HFD from PND 21 to 120 followed by CTR diet (gestation and lactation (G) intervention) and bred at PND 120. At 19 days of gestation maternal serum corticosterone was increased in MO and the PG and G dams showed partial recovery with intermediate levels. In offspring, no effects were found in the elevated plus maze test. In the open field test, MO and G offspring showed increase zone entries, displaying less thigmotaxis; PG offspring showed partial recuperation of this behavior. During initial operant conditioning MO. PG and G offspring displayed decreased approach behavior with subsequent learning impairment during the acquisition of FR-1 and FR-5 operant conditioning for sucrose reinforcement. Motivation during the progressive ratio test increased in MO offspring; PG and G intervention recuperated this behavior. We conclude that dietary intervention can reverse negative effects of maternal HFD and offspring outcomes are potentially due to elevated maternal corticosterone. (C) 2012 ISDN. Published by Elsevier Ltd. All rights reserved.
C1 [Rodriguez-Gonzalez, G. L.; Reyes-Castro, L. A.; Ibanez, C.; Ramirez, A.; Chavira, R.; Larrea, F.; Zambrano, E.] Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Reprod Biol, Mexico City 14000, DF, Mexico.
   [Rodriguez, J. S.; Nathanielsz, P. W.] Univ Texas Hlth Sci Ctr San Antonio, Dept Obstet & Gynecol, Ctr Pregnancy & Newborn Res, San Antonio, TX 78229 USA.
C3 Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran -
   Mexico; University of Texas System; University of Texas Health Science
   Center at San Antonio
RP Zambrano, E (corresponding author), Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Reprod Biol, Mexico City 14000, DF, Mexico.
EM zamgon@unam.mx
RI Larrea, Fernando/AAC-1900-2021; Rodríguez-González,
   Guadalupe/AAB-1291-2021; Ibanez Chavez, Carlos Alberto/AAG-2398-2020;
   REYES CASTRO, LUIS ANTONIO/E-9896-2019
OI Rodriguez Gonzalez, Guadalupe Leticia/0000-0002-3267-4793; Zambrano,
   Elena/0000-0002-0362-9117; Nathanielsz, Peter/0000-0001-8410-6280;
   Ibanez Chavez, Carlos Alberto/0000-0002-3435-497X; REYES CASTRO, LUIS
   ANTONIO/0000-0003-0397-6810
FU Consejo Nacional de Ciencias y Tecnologia (CONACyT), Mexico [155166];
   NIH [HD 21350]; CONACyT
FX L.A. Reyes-Castro and G.L. Rodriguez-Gonzalez are graduate students from
   Doctorado en Ciencias Biomedicas, Facultad de Medicina, Universidad
   Nacional Autonoma de Mexico and are recipients of CONACyT fellowship.
   This work was supported by Consejo Nacional de Ciencias y Tecnologia
   (CONACyT 155166), Mexico and NIH HD 21350.
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NR 67
TC 62
Z9 68
U1 0
U2 16
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0736-5748
EI 1873-474X
J9 INT J DEV NEUROSCI
JI Int. J. Dev. Neurosci.
PD APR
PY 2012
VL 30
IS 2
BP 75
EP 81
DI 10.1016/j.ijdevneu.2011.12.012
PG 7
WC Developmental Biology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Developmental Biology; Neurosciences & Neurology
GA 916ND
UT WOS:000302109600003
PM 22239918
DA 2025-06-11
ER

PT J
AU Chaudhuri, A
   Watson, WS
   Pearn, J
   Behan, PO
AF Chaudhuri, A
   Watson, WS
   Pearn, J
   Behan, PO
TI The symptoms of chronic fatigue syndrome are related to abnormal ion
   channel function
SO MEDICAL HYPOTHESES
LA English
DT Article
ID FAMILIAL HEMIPLEGIC MIGRAINE; CALCIUM CHANNELS; SKELETAL-MUSCLE;
   SYNDROME-X; MECHANISMS; RECEPTORS; SCLEROSIS; RESPONSES; EXERCISE;
   SEIZURES
AB The pathogenesis of chronic fatigue syndrome (CFS) is unknown but one of the most characteristic features of the illness is fluctuation in symptoms which can be induced by physical and/or mental stress. Other conditions in which fluctuating fatigue occurs are caused by abnormal ion channels in the cell membrane. These include genetically determined channelopathies, e.g. hypokalemic periodic paralysis, episodic ataxia type 2 and acquired conditions such as neuromyotonia, myasthenic syndromes, multiple sclerosis and inflammatory demyelinating polyneuropathies. Our hypothesis is that abnormal ion channel function underlies the symptoms of CFS and this is supported also by the finding of abnormal cardiac-thallium(201) SPECT scans in CFS, similar to that found in syndrome X, another disorder of ion channels. CFS and syndrome X can have identical clinical symptoms. CFS may begin after exposure to specific toxins which are known to produce abnormal sodium ion channels. Finally, in CFS, increased resting energy expenditure (REE) occurs, a state influenced by transmembrane ion transport. The hypothesis that ion channels are abnormal in CFS may help to explain the fluctuating fatigue and other symptoms. (C) 2000 Harcourt Publishers Ltd.
C1 So Gen Hosp, Dept Nucl Med, Glasgow G51 4TF, Lanark, Scotland.
   Inst Neurol Sci, Univ Dept Neurol, Glasgow G51 4TF, Lanark, Scotland.
   Univ Queensland, Dept Child Hlth, Brisbane, Qld, Australia.
C3 University of Glasgow; University of Glasgow; University of Queensland
RP So Gen Hosp, Inst Neurol Sci, Univ Dept Neurol, 1345 Govan Rd, Glasgow G51 4TF, Lanark, Scotland.
EM osslv@clinmed.gla.ac.uk
OI Pearn, John/0000-0002-8815-2994
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NR 62
TC 25
Z9 25
U1 0
U2 3
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0306-9877
EI 1532-2777
J9 MED HYPOTHESES
JI Med. Hypotheses
PD JAN
PY 2000
VL 54
IS 1
BP 59
EP 63
DI 10.1054/mehy.1998.0822
PG 5
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 295PL
UT WOS:000085977000010
PM 10790725
DA 2025-06-11
ER

PT J
AU Rodrigues, DM
   Reis, RS
   Molle, RD
   Machado, TD
   Mucellini, AB
   Bortoluzzi, A
   Toazza, R
   Pérez, JA
   Salum, GA
   Agranonik, M
   Minuzzi, L
   Levitan, RD
   Buchweitz, A
   Franco, AR
   Manfro, GG
   Silveira, PP
AF Rodrigues, Danitsa Marcos
   Reis, Roberta Sena
   Molle, Roberta Dalle
   Machado, Tania Diniz
   Mucellini, Amanda Brondani
   Bortoluzzi, Andressa
   Toazza, Rudineia
   Perez, Juliano Adams
   Salum, Giovanni Abrahao
   Agranonik, Marilyn
   Minuzzi, Luciano
   Levitan, Robert D.
   Buchweitz, Augusto
   Franco, Alexandre Rosa
   Manfro, Gisele Gus
   Silveira, Patricia Pelufo
TI Decreased comfort food intake and allostatic load in adolescents
   carrying the A3669G variant of the glucocorticoid receptor gene
SO APPETITE
LA English
DT Article
DE Glucocorticoid receptor gene polymorphism; Feeding behaviour; Comfort
   food; Reward circuitry; Insulin
ID PITUITARY-ADRENAL AXIS; STRIATAL DOPAMINE RELEASE; IN-VIVO; PSYCHOSOCIAL
   STRESS; POLYMORPHISM A3669G; ABDOMINAL OBESITY; BIPOLAR DISORDER;
   SELF-MEDICATION; MESSENGER-RNA; BETA-ISOFORM
AB Background: The A3669G single nucleotide polymorphism (SNP) of the glucocorticoid receptor (GR) gene NR3C1 is associated with altered tissue sensitivity to glucocorticoids (GCs). GCs modulate the food reward circuitry and are implicated in increased intake of palatable foods, which can lead to the metabolic syndrome and obesity. We hypothesized that presence of the G variant of the A3669G SNP would affect preferences for palatable foods and alter metabolic, behavioural, and neural outcomes.
   Methods: One hundred thirty-one adolescents were genotyped for the A3669G polymorphism, underwent anthropometric assessment and nutritional evaluations, and completed behavioural measures. A subsample of 74 subjects was followed for 5 years and performed a brain functional magnetic resonance imaging (fMRI) paradigm to verify brain activity in response to food cues.
   Results: Sugar and total energy consumption were lower in A3669G G allele variant carriers. On followup, this group also had reduced serum insulin concentrations, increased insulin sensitivity, and lower anxiety scores. Because of our unbalanced sample sizes (31/37 participants non-G allele carriers/total), our imaging data analysis failed to find whole brain-corrected significant results in between-group t-tests.
   Conclusion: These results highlight that a genetic variation in the GR gene is associated, at the cellular level, with significant reduction in GC sensitivity, which, at cognitive and behavioural levels, translates to altered food intake and emotional stress response. This genetic variant might play a major role in decreasing risk for metabolic and psychiatric diseases. (C) 2017 Elsevier Ltd. All rights reserved.
C1 [Rodrigues, Danitsa Marcos; Bortoluzzi, Andressa; Toazza, Rudineia; Manfro, Gisele Gus; Silveira, Patricia Pelufo] Univ Fed Rio Grande do Sul, Grad Program Neurosci, Porto Alegre, RS, Brazil.
   [Rodrigues, Danitsa Marcos; Mucellini, Amanda Brondani; Bortoluzzi, Andressa; Toazza, Rudineia; Salum, Giovanni Abrahao; Manfro, Gisele Gus] Univ Fed Rio Grande do Sul, Anxiety Disorders Program Child & Adolescent Psyc, Porto Alegre, RS, Brazil.
   [Reis, Roberta Sena; Molle, Roberta Dalle; Machado, Tania Diniz] Univ Fed Rio Grande do Sul, Grad Program Child & Adolescent Hlth, Porto Alegre, RS, Brazil.
   [Mucellini, Amanda Brondani; Salum, Giovanni Abrahao; Manfro, Gisele Gus] Univ Fed Rio Grande do Sul, Grad Program Psychiat & Behav Sci, Porto Alegre, RS, Brazil.
   [Perez, Juliano Adams] HCPA, Computed Tomog & Magnet Resonance Unit, Porto Alegre, RS, Brazil.
   [Agranonik, Marilyn] Fundacao Econ & Estat, Stat Informat Ctr, Porto Alegre, RS, Brazil.
   [Minuzzi, Luciano] McMaster Univ, Dept Psychiat & Behav Neurosci, Hamilton, ON, Canada.
   [Buchweitz, Augusto; Franco, Alexandre Rosa] Pontificia Univ Catolica Rio Grande do Sul, Brain Inst Rio Grande do Sul InsCer, Porto Alegre, RS, Brazil.
   [Silveira, Patricia Pelufo] McGill Univ, Dept Psychiat, Montreal, PQ, Canada.
   [Levitan, Robert D.] Univ Toronto, Dept Psychiat, Toronto, ON, Canada.
C3 Universidade Federal do Rio Grande do Sul; Universidade Federal do Rio
   Grande do Sul; Universidade Federal do Rio Grande do Sul; Universidade
   Federal do Rio Grande do Sul; McMaster University; Pontificia
   Universidade Catolica Do Rio Grande Do Sul; McGill University;
   University of Toronto
RP Rodrigues, DM (corresponding author), Hosp Clin Porto Alegre, Ramiro Barcelos 2350, BR-90035003 Porto Alegre, RS, Brazil.
EM danitsarodrigues@gmail.com
RI Silveira, Patricia/A-7139-2011; Machado, Tania/AAQ-1446-2020; Minuzzi,
   Luciano/ABH-3481-2020; Manfro, Gisele/B-7020-2009; Franco,
   Alexandre/D-1706-2015; Agranonik, Marilyn/B-8416-2015; Brondani
   Mucellini, Amanda/C-7248-2015; Salum, Giovanni/A-7849-2010; Silveira,
   Patricia/F-4897-2014; Buchweitz, Augusto/G-3829-2012
OI Agranonik, Marilyn/0000-0003-2699-9628; Brondani Mucellini,
   Amanda/0000-0002-8707-8585; Machado, Tania/0000-0002-3706-4185; Salum,
   Giovanni/0000-0002-7537-7289; Silveira, Patricia/0000-0001-8626-2519;
   Buchweitz, Augusto/0000-0003-3791-7472
FU Brazilian National Council for Technological and Scientific Development
   (CNPq) Brazil [478820/2010]; Coordination for the Improvement of Higher
   Education Personnel (CAPES) [3024/2010]; Fundo de Incentivo a Pesquisa e
   Eventos do Hospital de Clinicas de Porto Alegre (FIPE/HCPA) [12-0254]
FX Brazilian National Council for Technological and Scientific Development
   (CNPq) Brazil 2010 (PPS, 478820/2010), Coordination for the Improvement
   of Higher Education Personnel (CAPES) number 3024/2010 and Fundo de
   Incentivo a Pesquisa e Eventos do Hospital de Clinicas de Porto Alegre
   (FIPE/HCPA), project number 12-0254.
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NR 67
TC 8
Z9 10
U1 0
U2 17
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 0195-6663
EI 1095-8304
J9 APPETITE
JI Appetite
PD SEP 1
PY 2017
VL 116
BP 21
EP 28
DI 10.1016/j.appet.2017.04.004
PG 8
WC Behavioral Sciences; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Behavioral Sciences; Nutrition & Dietetics
GA FB2KM
UT WOS:000405972700003
PM 28400302
OA Green Published
DA 2025-06-11
ER

PT J
AU Strawbridge, AB
   Elmendorf, JS
AF Strawbridge, AB
   Elmendorf, JS
TI Endothelin-1 impairs glucose transporter trafficking via a
   membrane-based mechanism
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Article
DE actin; Cbl; insulin resistance; phosphatidylinositol 4,5-bispliosphate
ID INSULIN-RESISTANCE SYNDROME; TYPE-2 DIABETES-MELLITUS;
   PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE; PLASMA ENDOTHELIN-1;
   GLUCOSE-TRANSPORTER-4 TRANSLOCATION; GLUT4 TRANSLOCATION; ACTIN
   CYTOSKELETON; FILAMENTOUS ACTIN; 3T3-L1 ADIPOCYTES; SIGNALING PATHWAY
AB Endothelin-1 (ET-1) disrupts insulin-regulated glucose transporter GLUT4 trafficking. Since the negative consequence of chronic ET-1 exposure appears to be independent of signal disturbance along the insulin receptor substrate-1/phosphatidyl inositol (PI) 3-kinase (PI3K)/Akt-2 pathway Of insulin action, we tested if ET-1 altered GLUT4 regulation engaged by osmotic shock, a PI3K-independent Stimulus that mimics insulin action. Regulation of GLUT4 by hyperosmotic stress was impaired by ET-1. Because of the mutual disruption of both insulin- and hyperosmolarity-stimulated GLUT4 translocation, we tested whether shared signaling and/or key phosphatidylinositol 4,5-bisphosphate (PIP2)-regulated cytoskeletal events of GLUT4 trafficking were targets of ET-1. Both insulin and hyperosmotic stress signaling to Cbl were impaired by ET-1. Also, plasma membrane PIP2 and cortical actin levels were reduced in cells exposed to ET-1. Exogenous PIP2, but not PI 3,4,5-bisphosphate, restored actin structure, Cbl activation, and GLUT4 translocation. These data show that ET-1-induced PIP2/actin disruption impairs GLUT4 trafficking elicited by insulin and hyperosmolarity. In addition to showing for the first time the important role Of PIP2-regulated cytoskeletal events in GLUT4 regulation by stimuli other than insulin, these studies reveal a novel function Of PIP2/actin structure in signal transduction.
C1 Indiana Univ, Sch Med, Ctr Diabet Res, Dept Cellular & Integrat Physiol, Indianapolis, IN USA.
   Indiana Univ, Sch Med, Ctr Diabet Res, Dept Biochem & Mol Biol, Indianapolis, IN USA.
C3 Indiana University System; Indiana University Indianapolis; Indiana
   University System; Indiana University Indianapolis
RP 635 Barnhill Dr,MS308A, Indianapolis, IN 46202 USA.
EM jelmendo@iupui.edu
FU NCCIH NIH HHS [R01 AT001846, R01-AT001846] Funding Source: Medline
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NR 55
TC 22
Z9 27
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0730-2312
EI 1097-4644
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PD MAR 1
PY 2006
VL 97
IS 4
BP 849
EP 856
DI 10.1002/jcb.20687
PG 8
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA 021BV
UT WOS:000235958500018
PM 16240321
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Dwyer, BE
   Zacharski, LR
   Balestra, DJ
   Lerner, AJ
   Perry, G
   Zhu, XW
   Smith, MA
AF Dwyer, Barney E.
   Zacharski, Leo R.
   Balestra, Dominic J.
   Lerner, Alan J.
   Perry, George
   Zhu, Xiongwei
   Smith, Mark A.
TI Getting the iron out: Phlebotomy for Alzheimer's disease?
SO MEDICAL HYPOTHESES
LA English
DT Article
ID INSULIN-RESISTANCE SYNDROME; INDUCED OXIDATIVE STRESS; BRAIN FERRITIN
   IRON; BODY IRON; TAU PHOSPHORYLATION; RESPONSIVE ELEMENT; VASCULAR
   DISORDER; SENILE PLAQUES; STORED IRON; ATHEROSCLEROSIS
AB This communication explores the temporal link between the age-associated increase in body iron stores and the age-related incidence of Alzheimer's disease (AD), the most prevalent cause of senile dementia. Body iron stores that increase with age could be pivotal to AD pathogenesis and progression. Increased stored iron is associated with common medical conditions such as diabetes and vascular disease that increase risk for development of AD. Increased stored iron could also promote oxidative stress/free radical damage in vulnerable neurons, a critical early change in AD. A ferrocentric model of AD described here forms the basis of a rational, easily testable experimental therapeutic approach for AD, which if successful, would be both widely applicable and inexpensive. Clinical studies have shown that calibrated phlebotomy is an effective way to reduce stored iron safely and predictably without causing anemia. We hypothesize that reducing stored iron by calibrated phlebotomy to avoid iron deficiency will improve cerebrovascular function, slow neurodegenerative change, and improve cognitive and behavioral functions in AD. The hypothesis is eminently testable as iron reduction therapy is useful for chronic diseases associated with iron excess such as nonalcoholic steatohepatitis (NASH), atherosclerosis, hereditary hemochromatosis and thalassemia. Testing this hypothesis could provide valuable insight into the causation of AD and suggest novel preventive and treatment strategies. Published by Elsevier Ltd.
C1 [Dwyer, Barney E.; Zacharski, Leo R.; Balestra, Dominic J.] Dept Vet Affairs Med Ctr, Res Serv, White River Jct, VT USA.
   [Dwyer, Barney E.; Zacharski, Leo R.; Balestra, Dominic J.] Dartmouth Med Sch, Dept Med, Lebanon, NH USA.
   [Lerner, Alan J.] Univ Hosp Case Med Ctr, Dept Neurol, Cleveland, OH USA.
   [Perry, George; Zhu, Xiongwei; Smith, Mark A.] Case Western Reserve Univ, Dept Pathol, Cleveland, OH 44106 USA.
   [Perry, George] Univ Texas San Antonio, Coll Sci, San Antonio, TX USA.
C3 Dartmouth College; University System of Ohio; Case Western Reserve
   University; Case Western Reserve University Hospital; University System
   of Ohio; Case Western Reserve University; University of Texas System;
   University of Texas at San Antonio (UTSA)
RP Dwyer, BE (corresponding author), VA Med Ctr, Res Serv 151, 215 N Main St, White River Jct, VT 05009 USA.
EM Barney.E.Dwyer@Dartmouth.edu; mark.smith@case.edu
RI Smith, Mark/A-9053-2009; Zhu, Xiongwei/A-9629-2009; Perry,
   George/A-8611-2009
OI Perry, George/0000-0002-6547-0172
FU NIA NIH HHS [R01 AG026151, R01 AG024028] Funding Source: Medline
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NR 97
TC 28
Z9 30
U1 0
U2 6
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0306-9877
EI 1532-2777
J9 MED HYPOTHESES
JI Med. Hypotheses
PD MAY
PY 2009
VL 72
IS 5
BP 504
EP 509
DI 10.1016/j.mehy.2008.12.029
PG 6
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 426XW
UT WOS:000264742800006
PM 19195795
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Menon, K
   Cameron, JD
   de Courten, M
   de Courten, B
AF Menon, Kirthi
   Cameron, James D.
   de Courten, Maximilian
   de Courten, Barbora
TI Use of carnosine in the prevention of cardiometabolic risk factors in
   overweight and obese individuals: study protocol for a randomised,
   double-blind placebo-controlled trial
SO BMJ OPEN
LA English
DT Article
DE general diabetes; public health; cardiology
ID GLYCATION END-PRODUCTS; EXERCISE PERFORMANCE; OXIDATIVE STRESS;
   SUPPLEMENTATION; HISTIDINE; GLUCOSE; DISEASE; TRIGLYCERIDES;
   INFLAMMATION; ASSOCIATION
AB IntroductionCarnosine, an over the counter food supplement, has been shown to improve glucose metabolism as well as cardiovascular risk factors in animal and human studies through its anti-inflammatory, antioxidative, antiglycating and chelating properties. The aim of this study is to establish if carnosine supplementation improves obesity, insulin sensitivity, insulin secretion, cardiovascular risk factors including arterial stiffness and endothelial function, and other risk factors related to diabetes and cardiovascular disease in the overweight and obese population.Methods and analysisFifty participants will be recruited to be enrolled in a double-blind randomised controlled trial. Eligible participants with a body mass index (BMI) between 25 and 40 kg/m(2) will be randomly assigned to the intervention or placebo group. Following a medical review and oral glucose tolerance test to check eligibility, participants will then undergo testing. At baseline, participants will have anthropometric measurements (BMI, dual X-ray absorptiometry and peripheral quantitative CT scan), measurements of glucose metabolism (oral glucose tolerance test, intravenous glucose tolerance test and euglycaemic hyperinsulinaemic clamp), cardiovascular measurements (central blood pressure, endothelial function and arterial stiffness), a muscle and fat biopsy, physical activity measurement, liver fibroscan, cognitive function and questionnaires to assess dietary habits, sleep quality, depression, and quality of life. Following baseline assessments, participants will be randomised to either 2g carnosine or placebo for 15 weeks. In the 15th week, all assessments will be repeated. The preplanned outcome metric is the change between baseline and follow-up measures.Ethics and disseminationThis study is approved by the Human Research Ethics Committee of Monash Health and Monash University, Australia.Trial registration numberNCT02686996.
C1 [Menon, Kirthi; de Courten, Maximilian] Monash Univ, Sch Publ Hlth & Prevent Med, Melbourne, Vic, Australia.
   [Cameron, James D.] MonashHeart & Monash Cardiovasc Res Ctr, Melbourne, Vic, Australia.
   [Cameron, James D.; de Courten, Barbora] Monash Univ, Sch Clin Sci, Melbourne, Vic, Australia.
   [de Courten, Maximilian] Victoria Univ, Mitchell Inst, Melbourne, Vic, Australia.
C3 Monash University; Monash University; Victoria University
RP de Courten, B (corresponding author), Monash Univ, Sch Clin Sci, Melbourne, Vic, Australia.
EM barbora.decourten@monash.edu
RI Cameron, james/GQP-4595-2022; de Courten, Barbora/B-3308-2012; de
   Courten, Maximilian/B-3300-2012
OI de Courten, Barbora/0000-0001-8760-2511; Cameron,
   James/0000-0003-0589-0367; de Courten, Maximilian/0000-0001-9997-9359
FU Royal Australasian College of Physicians; Monash University
FX This work was supported by the Royal Australasian College of Physicians.
   Carnosine supplement (CarnoPureTM) is received from Flamma S.p.A, Italy.
   There are no award or grant numbers for the funds or support received.
   KM is a recipient of the Research Training Programme (RTP) scholarship
   provided by Monash University. BdC is supported by Fellows Career
   Development Fellowship from the the Royal Australasian College of
   Physicians.
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NR 73
TC 5
Z9 6
U1 0
U2 3
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2044-6055
J9 BMJ OPEN
JI BMJ Open
PD MAY
PY 2021
VL 11
IS 5
AR e043680
DI 10.1136/bmjopen-2020-043680
PG 10
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA ZL4KH
UT WOS:000763646700012
PM 33986049
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Kappes, C
   Stein, R
   Koerner, A
   Merkenschlager, A
   Kiess, W
AF Kappes, Claudia
   Stein, Robert
   Koerner, Antje
   Merkenschlager, Andreas
   Kiess, Wieland
TI Stress, Stress Reduction and Obesity in Childhood and Adolescence
SO HORMONE RESEARCH IN PAEDIATRICS
LA English
DT Review
DE Mindfulness; Stress; Childhood and adolescent obesity; Stress biology;
   Cortisol; COVID-19
ID BODY-MASS INDEX; HAIR CORTISOL CONCENTRATIONS;
   SYMPATHETIC-NERVOUS-SYSTEM; SALIVARY CORTISOL; DIURNAL CORTISOL;
   METABOLIC SYNDROME; PERCEIVED STRESS; EATING BEHAVIORS; CHILDREN; IMPACT
AB Background: Obesity in childhood and adolescence remains a great global health challenge. Stress exposure during childhood and adolescence is associated with a higher risk for obesity, yet the linkage between stress and obesity is multidimensional, and its biological and behavioral mechanisms are still not fully understood. Summary: In this literature review, we identified different types of stress exposure in children and adolescents, including first studied effects of the COVID-19 pandemic as a prolonged stress exposure and their association with obesity risk. We investigated studies on the connection of altered stress biology and behavioral pathways as well as intervention programs on stress reduction in children and adolescents with obesity. Key Messages: There is evidence that stress exposure in childhood and adolescence promotes biological and behavioral alterations that contribute to the multifactorial pathogenesis of obesity. COVID-19 related-stress presents the most current example of a negative influence on weight development in children and adolescents. However, longitudinal studies on the linkage between environmental, behavioral, and biological factors across development are few, and results are partly equivocal. Intervention programs to reduce stress in children through mindfulness might be a promising adjunctive tool in the prevention and treatment of childhood and adolescent obesity that could further offer proof of concept of theoretically elaborated cause-and-effect relationships.
C1 [Kappes, Claudia; Stein, Robert; Koerner, Antje; Merkenschlager, Andreas; Kiess, Wieland] Univ Leipzig, Univ Hosp Children & Adolescents, Med Fac, Leipzig, Germany.
   [Stein, Robert] Univ Leipzig, Helmholtz Inst Metab Obes & Vasc Res HI MAG, Helmholtz Zentrum Munchen, Leipzig, Germany.
C3 Leipzig University; Helmholtz Association; Helmholtz-Center Munich -
   German Research Center for Environmental Health; Leipzig University
RP Kappes, C (corresponding author), Univ Leipzig, Univ Hosp Children & Adolescents, Med Fac, Leipzig, Germany.
EM claudia.kappes@medizin.uni-leipzig.de
RI ; Korner, Antje/B-3988-2015
OI Stein, Robert/0000-0003-0896-9943; Korner, Antje/0000-0001-6001-0356
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NR 85
TC 23
Z9 23
U1 4
U2 32
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1663-2818
EI 1663-2826
J9 HORM RES PAEDIAT
JI Horm. Res. Paediatr.
PD MAR
PY 2023
VL 96
IS 1
BP 88
EP 96
DI 10.1159/000519284
PG 9
WC Endocrinology & Metabolism; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Pediatrics
GA D3WP4
UT WOS:000968068200011
PM 34469895
OA hybrid
DA 2025-06-11
ER

PT J
AU Lee, BK
   Durairaj, A
   Mehra, A
   Wenby, RB
   Meiselman, HJ
   Alexy, T
AF Lee, Byoung Kwon
   Durairaj, Azhil
   Mehra, Anilkumar
   Wenby, Rosalinda B.
   Meiselman, Herbert J.
   Alexy, Tamas
TI Microcirculatory dysfunction in cardiac syndrome X: Role of abnormal
   blood rheology
SO MICROCIRCULATION
LA English
DT Article
DE angina with normal coronary; cardiac syndrome X; blood rheology;
   erythrocyte aggregation
ID NORMAL CORONARY ARTERIOGRAMS; MYOCARDIAL HEMATOCRIT GRADIENT; WALL
   SHEAR-STRESS; CELL AGGREGATION; ANGINA-PECTORIS; CHEST-PAIN;
   MICROVASCULAR DYSFUNCTION; ENDOTHELIAL DYSFUNCTION; ARTERY-DISEASE;
   CLINICAL PRESENTATION
AB Objective: Cardiac syndrome X (CSX) is of clinical interest, yet the underlying pathophysiological mechanisms have not been fully elucidated. It is well known that elevated blood viscosity and red blood cell (RBC) aggregation can adversely affect microcirculatory blood flow. The present study was designed to explore whether CSX is associated with abnormalities of blood rheology.
   Methods: Blood samples were obtained from 152 adult angina patients undergoing diagnostic coronary angiography; geometric and flow-velocity data were obtained. Rheologic measurements were performed in a blinded manner; 21 subjects were later identified with CSX. Hemorheologic and clinical laboratory data were compared to 21 age- and gender-matched healthy controls.
   Results: CSX patients had markedly abnormal blood rheology: (1) higher RBC aggregation and aggregability as judged by erythrocyte sedimentation rate and Myrenne indices at stasis and low shear (p < 0.001) and (2) elevated hematocrit-corrected blood viscosity, plasma viscosity (p < 0.001), and yield stress (p < 0.01). White blood cell counts and high-sensitivity C-reactive protein levels were significantly elevated in CSX; coronary-flow velocities were below normal.
   Conclusions: Abnormal hemorheologic parameters exist in subjects with CSX and may contribute to the pathophysiology of the disease, presumably via adversely affecting blood flow in the coronary microcirculation. Therapeutic measures aimed at normalizing blood rheology and hence microcirculatory flow should be explored.
C1 [Lee, Byoung Kwon; Wenby, Rosalinda B.; Meiselman, Herbert J.; Alexy, Tamas] Univ So Calif, Keck Sch Med, Dept Phys & Biophys, Los Angeles, CA 90033 USA.
   [Lee, Byoung Kwon] Inje Univ, Coll Med, Div Cardiovasc, Sanggyepaik Hosp, Seoul, South Korea.
   [Durairaj, Azhil; Mehra, Anilkumar] Univ So Calif, Keck Sch Med, Div Cardiovasc Med, Los Angeles, CA 90033 USA.
C3 University of Southern California; Inje University; University of
   Southern California
RP Alexy, T (corresponding author), Univ So Calif, Keck Sch Med, Dept Phys & Biophys, 1333 San Pablo St,MMR 230, Los Angeles, CA 90033 USA.
EM alexy@usc.edu
RI Lee, Jeong Hoon/AAF-2400-2020
FU NHLBI NIH HHS [HL15722, HL70595] Funding Source: Medline
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NR 56
TC 31
Z9 34
U1 0
U2 7
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1073-9688
J9 MICROCIRCULATION
JI Microcirculation
PY 2008
VL 15
IS 5
BP 451
EP 459
DI 10.1080/10739680701797090
PG 9
WC Hematology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Hematology; Cardiovascular System & Cardiology
GA 317HP
UT WOS:000257011000008
PM 18574747
DA 2025-06-11
ER

PT J
AU Birditt, KS
   Newton, NJ
   Cranford, JA
   Webster, NJ
AF Birditt, Kira S.
   Newton, Nicky J.
   Cranford, Jim A.
   Webster, Noah J.
TI Chronic Stress and Negative Marital Quality Among Older Couples:
   Associations With Waist Circumference
SO JOURNALS OF GERONTOLOGY SERIES B-PSYCHOLOGICAL SCIENCES AND SOCIAL
   SCIENCES
LA English
DT Article
DE Couples; Negative marital quality; Stress; Waist circumference
ID BODY-MASS INDEX; ARTERY RISK DEVELOPMENT; SOCIAL RELATIONSHIPS;
   PSYCHOSOCIAL STRESS; GENDER-DIFFERENCES; METABOLIC SYNDROME; VISCERAL
   FAT; MARRIAGE; WEIGHT; HEALTH
AB Objective More than a third of the U.S. population of older adults is obese. The present study tests the Dyadic Biopsychosocial Model of Marriage and Health, which hypothesizes that, among married couples, individual and partner chronic stress predicts increased waist circumference and these links are exacerbated in negative quality marriages.
   Method Participants were from the nationally representative longitudinal Health and Retirement Study (HRS). A total of 2,042 married individuals (in 1,098 married couples) completed psychosocial and waist circumference assessments in 2006 and 2010. Analyses examined whether negative marital quality and chronic stress in Wave 1 (2006) were associated with changes in waist circumference over time.
   Results Actor-partner interdependence models revealed that greater partner stress, rather than individuals' own reports of stress, was associated with increased waist circumference over time. Higher perceived negative marital quality among husbands and lower negative marital quality among wives exacerbated the positive link between partner stress and waist circumference.
   Discussion Consistent with the Dyadic Biopsychosocial Model of Marriage and Health, partner stress has direct associations with waist circumference among couples and this link is moderated by negative marital quality. Thus, dyadic perceptions of stress and negative marital quality are important to consider for understanding marriage and obesity.
C1 [Birditt, Kira S.; Webster, Noah J.] Univ Michigan, Inst Social Res, Life Course Dev Program, 426 Thompson St, Ann Arbor, MI 48104 USA.
   [Newton, Nicky J.] Wilfrid Laurier Univ, Dept Psychol, Waterloo, ON, Canada.
   [Cranford, Jim A.] Univ Michigan, Dept Psychiat, Ann Arbor, MI 48109 USA.
C3 University of Michigan System; University of Michigan; Wilfrid Laurier
   University; University of Michigan System; University of Michigan
RP Birditt, KS (corresponding author), Univ Michigan, Inst Social Res, Life Course Dev Program, 426 Thompson St, Ann Arbor, MI 48104 USA.
EM kirasb@umich.edu
FU National Institute on Aging [NIA U01AG009740]; National Institute on
   Aging [U01AG009740, P30AG024824] Funding Source: NIH RePORTER
FX The Health and Retirement Study (HRS) is sponsored by the National
   Institute on Aging (grant number NIA U01AG009740) and is conducted by
   the University of Michigan.
CR Adam TC, 2007, PHYSIOL BEHAV, V91, P449, DOI 10.1016/j.physbeh.2007.04.011
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NR 52
TC 8
Z9 8
U1 3
U2 14
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1079-5014
EI 1758-5368
J9 J GERONTOL B-PSYCHOL
JI J. Gerontol. Ser. B-Psychol. Sci. Soc. Sci.
PD FEB
PY 2019
VL 74
IS 2
BP 318
EP 328
DI 10.1093/geronb/gbw112
PG 11
WC Geriatrics & Gerontology; Gerontology; Psychology; Psychology,
   Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Psychology
GA HQ6ZN
UT WOS:000462568900013
PM 27664418
OA Green Published
DA 2025-06-11
ER

PT J
AU Kadkhoda, G
   Zarkesh, M
   Saidpour, A
   Oghaz, MH
   Hedayati, M
   Khalaj, A
AF Kadkhoda, Golnoosh
   Zarkesh, Maryam
   Saidpour, Atoosa
   Oghaz, Masoumeh Hajizadeh
   Hedayati, Mehdi
   Khalaj, Alireza
TI Association of dietary intake of fruit and green vegetables with PTEN
   and P53 mRNA gene expression in visceral and subcutaneous adipose
   tissues of obese and non-obese adults
SO GENE
LA English
DT Article
DE Fruit; Vegetables; P53; PTEN; Gene expression; Obesity
ID INSULIN-RESISTANCE; CARDIOMETABOLIC RISK; METABOLIC SYNDROME; OXIDATIVE
   STRESS; BODY-WEIGHT; FAT INTAKE; CONSUMPTION; HEALTH; INFLAMMATION;
   PATHWAY
AB Objective The present study investigates the association of dietary intake of fruit and green Vegetables with PTEN and P53 mRNA gene expression in visceral (VAT) and subcutaneous adipose tissues (SAT) of obese and non-obese adults.
   Methods VAT and SAT were obtained from 151 individuals, aged similar to 40 years, who had undergone elective abdominal surgery. The participants were grouped according to their body mass index (BMI), as obese (BMI > 30 kg/m(2)) and non-obese (BMI = 18.5-30 kg/m2). Dietary intakes were obtained using a valid and reliable food-frequency questionnaire (FFQ). Real-time PCR was carried out for PTEN and P53 mRNA expressions. Associations between expression levels and dietary parameters were analyzed.
   Results P53 mRNA expression of obese participants was significantly higher than the non-obese, only in VAT (p < 0.001). After adjusting for total energy intake, age and BMI, fruit intake was inversely associated with P53 gene expression in both VAT (beta = -0.38, P = 0.01) and SAT (beta = -0.35, P = 0.03) among non-obese participants. Furthermore, fruit consumption was inversely associated with P53 gene expression in obese individuals, only in VAT (beta = -0.21, P = 0.05). More so, intake of green vegetables in obese subjects was negatively associated with P53 gene expression in VAT (beta = -0.27, P = 0.01) and SAT (beta = -0.28, P < 0.001). On the other hand, after adjustment for total energy intake, age and BMI, a positive association was observed between fruit intake and PTEN in VAT (beta = 0.27, P = 0.01) and SAT (beta = 0.34, P < 0.001) among obese participants. In addition, dietary consumption of fruits in non-obese individuals was negatively associated withPTEN expression in SAT (beta = -0.48, P < 0.001).
   Conclusion Dietary intake of fruit and green vegetables was associated with P53 gene expression in VAT and SAT of obese participants, suggesting their protective role in regulating P53 mRNA expression in adipose tissue. Furthermore, higher fruit intake was inversely associated with PTEN mRNA levels in non-obese participants, implying the anti-adipogenic role of PTEN gene expression.
C1 [Kadkhoda, Golnoosh; Saidpour, Atoosa; Oghaz, Masoumeh Hajizadeh] Shahid Beheshti Univ Med Sci, Fac Nutr Sci & Food Technol, Natl Nutr & Food Technol Res Inst, Dept Clin Nutr & Dietet, Tehran, Iran.
   [Zarkesh, Maryam; Hedayati, Mehdi] Shahid Beheshti Univ Med Sci, Cellular & Mol Endocrine Res Ctr, Res Inst Endocrine Sci, Tehran, Iran.
   [Khalaj, Alireza] Shahed Univ, Tehran Obes Treatment Ctr, Dept Surg, Tehran, Iran.
C3 Shahid Beheshti University Medical Sciences; Shahid Beheshti University
   Medical Sciences; Shahed University
RP Saidpour, A (corresponding author), Shahid Beheshti Univ Med Sci, Fac Nutr Sci & Food Technol, Natl Nutr & Food Technol Res Inst, Dept Clin Nutr & Dietet, Tehran, Iran.; Zarkesh, M (corresponding author), Shahid Beheshti Univ Med Sci, Cellular & Mol Endocrine Res Ctr, Res Inst Endocrine Sci, Tehran, Iran.
EM zarkesh@endocrine.ac.ir; saidpour@sbmu.ac.ir; hedayati@endocrine.ac.ir;
   khalaj@totc.ir
RI Hedayati, Mehdi/AAG-3006-2019; Zarkesh, Maryam/ABC-1782-2021; saidpour,
   atoosa/Q-1135-2019
OI Zarkesh, Maryam/0000-0002-8519-4865; saidpour,
   atoosa/0000-0002-8442-7620
FU Research Institute for Endocrine Sciences (RIES) of the Shahid Beheshti
   University of Medical Sciences in Tehran, Iran
   [IR.SBMU.ENDOCRINE.REC.1395.283]
FX This study was funded by the Research Institute for Endocrine Sciences
   (RIES) of the Shahid Beheshti University of Medical Sciences in Tehran,
   Iran (IR.SBMU.ENDOCRINE.REC.1395.283).
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NR 51
TC 5
Z9 5
U1 0
U2 5
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0378-1119
EI 1879-0038
J9 GENE
JI Gene
PD APR 5
PY 2020
VL 733
AR 144353
DI 10.1016/j.gene.2020.144353
PG 7
WC Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Genetics & Heredity
GA KR0ZA
UT WOS:000517347900008
PM 31978509
DA 2025-06-11
ER

PT J
AU Alazmi, AHS
   Khiriy, SA
   Khiriy, MA
   Alabdulaal, FA
   Aldossry, KMH
   Alshammari, KR
   Al Otaibi, RHS
   Alrowaily, MJ
   Sawadi, HAM
   Al-Shahrani, SN
   Alanzei, NAS
   Aldossri, BMM
   Alruwaily, KMAA
   Aldosari, HNF
   Al-Anzi, AS
   Al-Moshawwh, MA
AF Alazmi, Amnah Hameed Saleem
   Khiriy, Shujun Ahmad
   Khiriy, Muadia Ahmad
   Alabdulaal, Fatimah Abdullah
   Aldossry, Khalaf Mubark Hanian
   Alshammari, Khulud Raja
   Al Otaibi, Rehab Hamood Salim
   Alrowaily, Maram Jaber
   Sawadi, Hassan Abdoh Mohammed
   Al-Shahrani, Salhah Nasser
   Alanzei, Noha Abdullah Suliman
   Aldossri, Badar Majid Mubark
   Alruwaily, Khalid Mohammed Abed Alruwaily
   Aldosari, Haya Nasser Fahad
   Al-Anzi, Aziza Saud
   Al-Moshawwh, Majed Abdullah
TI Comprehensive Nursing Care in Coronary Heart Disease: Biochemical
   Markers, Strategies, Challenges, and Evidence-Based Approaches for
   Effective Patient Management and Outcomes
SO EGYPTIAN JOURNAL OF CHEMISTRY
LA English
DT Article
DE Coronary Heart Disease; Nursing Care; Patient Management; Pediatric
   Patients; Elderly Patients; Risk Factors; Lifestyle Modifications;
   Evidence-Based Practice; Clinical Outcomes; Mental Health
ID ARTERY-BYPASS GRAFT; RANDOMIZED CONTROLLED-TRIAL; CARDIOVASCULAR
   RISK-FACTORS; QUALITY-OF-LIFE; MYOCARDIAL-INFARCTION; SELF-CARE;
   METABOLIC SYNDROME; OBESITY; INTERVENTION; DIAGNOSIS
AB Background: Coronary heart disease (CHD) is a leading cause of morbidity and mortality globally, posing significant challenges for patient care across diverse populations. Nurses play a critical role in the prevention, management, and rehabilitation of patients with CHD, contributing to improved clinical outcomes and quality of life. This review explores evidence-based approaches and strategies for effective nursing care in CHD management, emphasizing the unique considerations for pediatric and elderly patients. Aim: The aim of this review is to critically examine the role of nurses in managing CHD, focusing on the prevention of risk factors, patient education, and care strategies across the lifespan, with particular attention to the pediatric and elderly populations. Methods: This review synthesizes findings from current literature on the role of nursing care in CHD management, including the impact of interventions aimed at change in behavioral, mental health support, and clinical outcomes. A particular focus is given to nursing interventions in the management of obesity, cardiovascular risk factors, and the distinctive challenges faced by pediatric and elderly populations with CHD. Results: Evidence shows that nursing interventions, including patient education, lifestyle modification support, and continuity of care, significantly improve self-care capacity, disease knowledge, and self-efficacy in patients with CHD. For pediatric and elderly populations, tailored care strategies are essential due to their unique physiological and psychological needs. In pediatric cases, nurses play a crucial role in early detection and family support, while in elderly patients, comprehensive care addressing polypharmacy, cognitive decline, and comorbidities is vital. Additionally, nurses have been shown to contribute to improved clinical parameters such as blood pressure, cholesterol levels, and physical activity adherence, along with better mental health outcomes. Conclusion: Nurses are central to the management and treatment of CHD, with evidence supporting the positive impact of their interventions on patient outcomes. Effective nursing care, particularly in the pediatric and elderly populations, requires a tailored, patient-centered approach that considers age-specific needs, comorbidities, and psychosocial factors. Continued research into nursing strategies and interventions is essential for optimizing care and improving long-term outcomes for patients with CHD.
C1 [Alazmi, Amnah Hameed Saleem; Al Otaibi, Rehab Hamood Salim; Al-Moshawwh, Majed Abdullah] Minist Hlth, Riyadh Hlth Cluster 1, Riyadh, Saudi Arabia.
   [Khiriy, Shujun Ahmad; Khiriy, Muadia Ahmad; Al-Shahrani, Salhah Nasser] Minist Hlth, Hlth Cluster 1, Riyadh, Saudi Arabia.
   [Alabdulaal, Fatimah Abdullah] Minist Hlth, Prince Mohammad Bin Fahd Hosp, Riyadh, Saudi Arabia.
   [Aldossry, Khalaf Mubark Hanian] Minist Hlth, Wadi Aldawasir Hosp, Riyadh, Saudi Arabia.
   [Alshammari, Khulud Raja] Minist Hlth, Erada & Mental Hlth Hosp, Riyadh, Saudi Arabia.
   [Alrowaily, Maram Jaber] Minist Hlth, Hlth Cluster 2, Riyadh, Saudi Arabia.
   [Sawadi, Hassan Abdoh Mohammed] Minist Hlth, Irada Mental Hlth Hosp Jazan Jazan Hlth Cluster, Riyadh, Saudi Arabia.
   [Alanzei, Noha Abdullah Suliman] Minist Hlth, Al Seih Hlth Care Ctr, Riyadh, Saudi Arabia.
   [Aldossri, Badar Majid Mubark] Minist Hlth, Hlth Cluster Riyadh 1, Riyadh, Saudi Arabia.
   [Alruwaily, Khalid Mohammed Abed Alruwaily] Minist Hlth, King Khalid Hosp, Al Haytham Hlth Ctr, Najran, Saudi Arabia.
   [Aldosari, Haya Nasser Fahad] Minist Hlth, Bani Malik Gen Hosp, Bani Malik St, Abha 62526, Saudi Arabia.
   [Al-Anzi, Aziza Saud] Minist Hlth, Al Qasumah Gen Hosp, Al Qassim, Saudi Arabia.
C3 Ministry of Health - Saudi Arabia; Ministry of Health - Saudi Arabia;
   Ministry of Health - Saudi Arabia; Ministry of Health - Saudi Arabia;
   Ministry of Health - Saudi Arabia; Ministry of Health - Saudi Arabia;
   Ministry of Health - Saudi Arabia; Ministry of Health - Saudi Arabia;
   Ministry of Health - Saudi Arabia; King Khalid Hospital
RP Alazmi, AHS (corresponding author), Minist Hlth, Riyadh Hlth Cluster 1, Riyadh, Saudi Arabia.
EM ahalazmi@moh.gov.sa
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NR 81
TC 0
Z9 0
U1 0
U2 0
PU National Information & Documentation Centre-NIDOC
PI CAIRO
PA NIDOC DOKKI, CAIRO, 00000, EGYPT
SN 0449-2285
EI 2357-0245
J9 EGYPT J CHEM
JI Egypt. J. Chem.
PD DEC
PY 2024
VL 67
IS 13
BP 1449
EP 1463
DI 10.21608/ejchem.2024.335773.10782
PG 15
WC Chemistry, Multidisciplinary
WE Emerging Sources Citation Index (ESCI)
SC Chemistry
GA P9U0B
UT WOS:001381253100002
DA 2025-06-11
ER

PT J
AU Hamada, S
   Mae, Y
   Takata, T
   Hanada, H
   Kubo, M
   Taniguchi, S
   Iyama, T
   Sugihara, T
   Isomoto, H
AF Hamada, Shintaro
   Mae, Yukari
   Takata, Tomoaki
   Hanada, Hinako
   Kubo, Misaki
   Taniguchi, Sosuke
   Iyama, Takuji
   Sugihara, Takaaki
   Isomoto, Hajime
TI Five-Aminolevulinic Acid (5-ALA) Induces Heme Oxygenase-1 and
   Ameliorates Palmitic Acid-Induced Endoplasmic Reticulum Stress in Renal
   Tubules
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE Nrf2; Bach1; steatosis; kidney; lipotoxicity
ID CHRONIC KIDNEY-DISEASE; METABOLIC SYNDROME; OXIDATIVE STRESS; ER STRESS;
   EXPRESSION; DYSFUNCTION
AB Steatosis, or ectopic lipid deposition, is the fundamental pathophysiology of non-alcoholic steatohepatitis and chronic kidney disease. Steatosis in the renal tubule causes endoplasmic reticulum (ER) stress, leading to kidney injury. Thus, ER stress could be a therapeutic target in steatonephropathy. Five-aminolevulinic acid (5-ALA) is a natural product that induces heme oxygenase (HO)-1, which acts as an antioxidant. This study aimed to investigate the therapeutic potential of 5-ALA in lipotoxicity-induced ER stress in human primary renal proximal tubule epithelial cells. Cells were stimulated with palmitic acid (PA) to induce ER stress. Cellular apoptotic signals and expression of genes involved in the ER stress cascade and heme biosynthesis pathway were analyzed. The expression of glucose-regulated protein 78 (GRP78), a master regulator of ER stress, increased significantly, followed by increased cellular apoptosis. Administration of 5-ALA induced a remarkable increase in HO-1 expression, thus ameliorating PA-induced GRP78 expression and apoptotic signals. BTB and CNC homology 1 (BACH1), a transcriptional repressor of HO-1, was significantly downregulated by 5-ALA treatment. HO-1 induction attenuates PA-induced renal tubular injury by suppressing ER stress. This study demonstrates the therapeutic potential of 5-ALA against lipotoxicity through redox pathway.
C1 [Hamada, Shintaro; Mae, Yukari; Takata, Tomoaki; Hanada, Hinako; Kubo, Misaki; Taniguchi, Sosuke; Iyama, Takuji; Sugihara, Takaaki; Isomoto, Hajime] Tottori Univ, Fac Med, Div Gastroenterol & Nephrol, Tottori 6838504, Japan.
C3 Tottori University
RP Takata, T (corresponding author), Tottori Univ, Fac Med, Div Gastroenterol & Nephrol, Tottori 6838504, Japan.
EM t-takata@tottori-u.ac.jp
RI ; Takata, Tomoaki/AAC-9506-2020
OI Sugihara, Takaaki/0000-0003-0522-1884; Takata,
   Tomoaki/0000-0003-2959-6015
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NR 46
TC 6
Z9 6
U1 2
U2 5
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD JUN
PY 2023
VL 24
IS 12
AR 10151
DI 10.3390/ijms241210151
PG 12
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA K2TM1
UT WOS:001015015100001
PM 37373300
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Aydogdu, A
   Karakas, EY
   Erkus, E
   Altiparmak, IH
   Savik, E
   Ulas, T
   Sabuncu, T
AF Aydogdu, Ali
   Karakas, Emel Yigit
   Erkus, Emre
   Altiparmak, Ibrahim Halil
   Savik, Emin
   Ulas, Turgay
   Sabuncu, Tevfik
TI Epicardial fat thickness and oxidative stress parameters in patients
   with subclinical hypothyroidism
SO ARCHIVES OF MEDICAL SCIENCE
LA English
DT Article
DE epicardial fat thickness; oxidative stress; subclinical hypothyroidism
ID ADIPOSE-TISSUE; LIPID-PEROXIDATION; INSULIN-RESISTANCE; METABOLIC
   SYNDROME; THYROID-FUNCTION; OVERT; SERUM; ASSOCIATION; OBESITY; LEVEL
AB Introduction: Thyroid disorders are known to be a risk factor for cardiovascular diseases. Epicardial fat thickness (EFT) and oxidative stress are also believed to be major risk factors for cardiovascular events. The aim of this study was to evaluate the possible relationship between oxidative stress parameters and EFT in patients with subclinical hypothyroidism (SCH).
   Material and methods: A total of 60 individuals (30 patients with SCH and 30 healthy controls) were recruited for the study. The EFT and oxidative stress parameters of all participants were analyzed at baseline; the same were analyzed in SCH patients after achievement of a euthyroid state.
   Results: Compared to healthy subjects, SCH patients had significantly higher EFT and oxidative stress parameters (p < 0.05 for all). EFT and oxidative stress parameters both decreased after treatment, but only the decrease of EFT levels was statistically significant after thyroid hormone replacement (p < 0.05). Serum EFT levels were not significantly correlated with oxidative stress index (r = 0.141, p = 0.458).
   Conclusions: Previous studies have demonstrated that visceral adipose tissue and oxidative stress are major risk factors for cardiovascular events; our study demonstrated that EFT, a visceral adipose tissue, and oxidative stress parameters were higher, and could be used as an indicator for cardiovascular diseases in patients with SCH.
C1 [Aydogdu, Ali; Karakas, Emel Yigit; Ulas, Turgay] Harran Univ, Dept Internal Med, Fac Med, Yenisehir Campus, TR-63300 Sanliurfa, Turkey.
   [Erkus, Emre; Altiparmak, Ibrahim Halil] Harran Univ, Dept Cardiol, Fac Med, Sanliurfa, Turkey.
   [Savik, Emin] Harran Univ, Dept Biochem, Fac Med, Sanliurfa, Turkey.
   [Sabuncu, Tevfik] Harran Univ, Dept Internal Med & Endocrinol, Fac Med, Sanliurfa, Turkey.
C3 Harran University; Harran University; Harran University; Harran
   University
RP Karakas, EY (corresponding author), Harran Univ, Dept Internal Med, Fac Med, Yenisehir Campus, TR-63300 Sanliurfa, Turkey.
EM e.ygtkarakas@yahoo.com.tr
RI Erkuş, Emre/ABC-4126-2021; altıparmak, ibrahim/ABF-4178-2020; Ulas,
   Turgay/A-6050-2018; Sabuncu, Tevfik/ABF-5291-2020
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NR 39
TC 15
Z9 16
U1 0
U2 4
PU TERMEDIA PUBLISHING HOUSE LTD
PI POZNAN
PA KLEEBERGA ST 2, POZNAN, 61-615, POLAND
SN 1734-1922
EI 1896-9151
J9 ARCH MED SCI
JI Arch. Med. Sci.
PD MAR
PY 2017
VL 13
IS 2
BP 383
EP 389
DI 10.5114/aoms.2017.65479
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA EM5PW
UT WOS:000395365500014
PM 28261292
OA Green Submitted, gold, Green Published
DA 2025-06-11
ER

PT J
AU Juvinao-Quintero, DL
   Larrabure-Torrealva, GT
   Sanchez, SE
   Kirschbaum, C
   Williams, MA
   Gelaye, B
AF Juvinao-Quintero, Diana L.
   Larrabure-Torrealva, Gloria T.
   Sanchez, Sixto E.
   Kirschbaum, Clemens
   Williams, Michelle A.
   Gelaye, Bizu
TI Maternal hair cortisol concentrations and its association with increased
   insulin resistance in midpregnancy
SO ANNALS OF EPIDEMIOLOGY
LA English
DT Article
DE Hair cortisol concentrations; Chronic stress; GDM; Fasting insulin; HOMA
   scores; Pregnancy
ID SALIVARY CORTISOL; GLUCOSE; DETERMINANTS; PREGNANCY; HYPERGLYCEMIA;
   HOMEOSTASIS; METABOLISM; PREDICTOR; SECRETION; DISEASE
AB Purpose: Stress and elevated maternal glycemia have negative effects on pregnancy. We evaluated the as-sociation of hair cortisol concentrations (HCC), a marker of chronic stress, with insulin resistance and ge-stational diabetes (GDM).Methods: In total, 527 women from Lima, Peru, provided a hair sample in the second trimester of their pregnancy to measure HCC using liquid chromatography-tandem mass spectrometry. Each 6 cm of hair captured HCC in early (T1=1-12 weeks) and midpregnancy (T2 = 13-24 weeks). GDM diagnosis was con-ducted in midpregnancy. Multivariable regression models adjusted for putative risk factorsincluding ma-ternal sociodemographic factors, diabetes history, and hair characteristics, were used to estimate the association of HCC with GDM and various glycemic traits.Results: GDM was diagnosed in 122 (23%) women. Mean HCC across pregnancy was T1 = 3.7 ( +/- 3.4) pg/mg and T2 = 4.8 ( +/- 3.4) pg/mg. HCC was associated with increased log-transformed units of fasting insulin (T1 = 0.15 [0.03, 0.27], T2 = 0.17 [0.04, 0.30]), homeostasis model assessment for insulin resistance (T1 = 0.14 [0.01, 0.26], T2 = 0.17 [0.03, 0.30]), and homeostasis model assessment for beta-cell function (T1 = 0.20 [0.05, 0.34], T2 = 0.20 [0.04, 0.36]), but not with GDM (T1 = 0.95 [0.63, 1.40], T2 = 1.11 [0.74, 1.67]).Conclusions: Elevated maternal HCC was associated with abnormal insulin homeostasis in pregnancy. Dysregulation of the hypothalamic-pituitary-adrenal axis, as reflected by high HCC, may also contribute to insulin resistance syndrome in pregnancy.(c) 2023 Elsevier Inc. All rights reserved.
C1 [Juvinao-Quintero, Diana L.; Williams, Michelle A.; Gelaye, Bizu] Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA.
   [Larrabure-Torrealva, Gloria T.] Univ Nacl Mayor San Marcos, Dept Acad Med Humana, Lima, Peru.
   [Larrabure-Torrealva, Gloria T.] Inst Nacl Materno Perinatal, Lima, Peru.
   [Sanchez, Sixto E.] Univ San Martin Porres, Fac Med Humana, Inst Invest, Lima, Peru.
   [Kirschbaum, Clemens] Asociac Civil PROESA, Lima, Peru.
   [Gelaye, Bizu] Tech Univ Dresden, Dept Psychol, Dresden, Germany.
   [Gelaye, Bizu] Massachusetts Gen Hosp, Chester M Pierce MD Div Global Psychiat, Boston, MA USA.
   [Gelaye, Bizu] Harvard Med Sch, Ctr Bioeth, Boston, MA USA.
   [Juvinao-Quintero, Diana L.] 677 Huntington Ave Room 500, Boston, MA 02115 USA.
C3 Harvard University; Harvard T.H. Chan School of Public Health;
   Universidad Nacional Mayor de San Marcos; Universidad de San Martin de
   Porres; Technische Universitat Dresden; Harvard University; Harvard
   University Medical Affiliates; Massachusetts General Hospital; Harvard
   University; Harvard Medical School
RP Juvinao-Quintero, DL (corresponding author), 677 Huntington Ave Room 500, Boston, MA 02115 USA.
EM djq@hsph.harvard.edu
RI Kirschbaum, Clemens/AAB-1752-2020; SANCHEZ, SIXTO/HTO-5928-2023;
   Juvinao-Quintero, Diana/HYU-1922-2023; Gelaye, Bizu/GSI-6520-2022
OI Sanchez, Sixto/0000-0003-0354-0523
FU Roche Diagnostic Operations Inc [208617-5074547]; National Institute of
   Health [R21 HD102822]
FX Funding This study was supported by Roche Diagnostic Operations Inc
   (project number 208617-5074547) and the National Institute of Health
   (R21 HD102822) . Sponsors had no role in study design; in the
   collection, analysis, and interpretation of data; in the writing of the
   manuscript.
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NR 43
TC 2
Z9 3
U1 0
U2 3
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1047-2797
EI 1873-2585
J9 ANN EPIDEMIOL
JI Ann. Epidemiol.
PD MAY
PY 2023
VL 81
DI 10.1016/j.annepidem.2023.02.011
EA APR 2023
PG 18
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA F2AE8
UT WOS:000980416900001
PM 36841381
OA Bronze, Green Accepted
DA 2025-06-11
ER

PT J
AU Mezzetti, A
   Cipollone, F
   Cuccurullo, F
AF Mezzetti, A
   Cipollone, F
   Cuccurullo, F
TI Oxidative stress and cardiovascular complications in diabetes:
   isoprostanes as new markers on an old paradigm
SO CARDIOVASCULAR RESEARCH
LA English
DT Review
DE cholesterol; coronary disease; diabetes; free radicals; lipid metabolism
ID LOW-DENSITY-LIPOPROTEIN; PROSTAGLANDIN ENDOPEROXIDE SYNTHASE-2;
   ENDOTHELIUM-DEPENDENT RELAXATION; HUMAN ATHEROSCLEROTIC LESIONS;
   INSULIN-RESISTANCE SYNDROME; TISSUE FACTOR EXPRESSION; VASCULAR
   SMOOTH-MUSCLE; HIGH-GLUCOSE MEDIUM; IN-VIVO FORMATION; OXIDANT STRESS
AB Long-term vascular complications still represent the main cause of morbidity and mortality in diabetic patients. Although randomized long-term clinical studies comparing the effects of conventional and intensive therapy have demonstrated a clear link between hyperglycemia and the development of complications of diabetes, they have not defined the mechanism through which excess glucose results in tissue damage. Evidence has accumulated indicating that oxidative stress may play a key role in the etiology of diabetic complications. Isoprostanes are emerging as a new class of biologically active products of arachidonic acid metabolism of potential relevance to human Vascular disease. Their formation in vivo seems to reflect primarily, if not exclusively, a nonenzymatic process of Lipid peroxidation. Enhanced urinary excretion of 8-iso-PGF(2 alpha) has been described in association with both type 1 and type 2 diabetes mellitus, and correlates with impaired glycemic control. Besides providing a likely noninvasive index of lipid peroxidation in this setting, measurements of specific F-2 isoprostanes in urine may provide a sensitive biochemical end point for dose-finding studies of natural and synthetic inhibitors of lipid peroxidation. Although the biological effects of 8-iso-PGF(2 alpha) in vitro suggest that it and other isoeicosanoids may modulate the functional consequences of lipid peroxidation in diabetes, evidence that this is likely in vivo remains inadequate at this time. (C) 2000 Elsevier Science B.V. All rights reserved.
C1 Univ G DAnnunzio, Sch Med, Dept Med & Aging, Chieti, Italy.
C3 G d'Annunzio University of Chieti-Pescara
RP Nuovo Policlin SS Annunziata, Ctr Prevenz Aterosclerosi Diagnosi & Terapia Iper, Via Vestini 66, I-66013 Chieti, Italy.
EM mezzetti@unich.it
RI Cipollone, Francesco/AAC-5698-2022
OI Cipollone, Francesco/0000-0002-5993-9341
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NR 120
TC 130
Z9 156
U1 0
U2 7
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0008-6363
EI 1755-3245
J9 CARDIOVASC RES
JI Cardiovasc. Res.
PD AUG
PY 2000
VL 47
IS 3
BP 475
EP 488
DI 10.1016/S0008-6363(00)00118-8
PG 14
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 349QE
UT WOS:000089056500009
PM 10963721
OA Bronze
DA 2025-06-11
ER

PT J
AU Razavi, R
   Parvaresh, A
   Abbasi, B
   Yaghoobloo, K
   Hassanzadeh, A
   Mohammadifard, N
   Clark, CCT
   Safavi, SM
AF Razavi, Roghaye
   Parvaresh, Arefe
   Abbasi, Behnood
   Yaghoobloo, Khadijeh
   Hassanzadeh, Akbar
   Mohammadifard, Noushin
   Clark, Cain C. T.
   Safavi, Sayyed Morteza
TI The alternate-day fasting diet is a more effective approach than a
   calorie restriction diet on weight loss and hs-CRP levels
SO INTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCH
LA English
DT Article
DE Alternate-day fasting diet; energy restriction; inflammation; metabolic
   syndrome
ID METABOLIC SYNDROME; ENERGY-EXPENDITURE; OXIDATIVE STRESS;
   BODY-COMPOSITION; FAT DIET; OVERWEIGHT; IMPROVEMENTS; INFLAMMATION;
   BIOMARKERS; ADHERENCE
AB Background and Objective: The aim of present study was to compare, and determine, the effects of a modified alternate-day fasting diet vs. calorie restriction on inflammatory indices and coagulation factors. Methods: This was a randomized clinical trial consisting of 80 metabolic syndrome patients, who were enrolled and randomly dichotomized into a modified alternate-day fasting diet or calorie restriction group for 4 months. We measured weight, body mass index (BMI), waist circumstance (WC), waist-hip-ratio (WHR) and fat mass as primary outcomes and assessed high sensitivity C-reactive protein (hs-CRP), interleukin 6 (IL-6), tumor necrosis factor alpha (TNF-alpha) and coagulation factors levels as secondary outcomes before and after intervention. Results: Compared to the calorie restriction diet, following a modified alternate-day fasting diet led to a greater reduction in body weight (kg) (-6.43 +/- 4.34 vs -4.11 +/- 4.27; P = 0.02), BMI (kg/m(2)) (-3.19 +/- 2.90 vs -1.43 +/- 2.72; P = 0.01), fat mass (kg) (-4.88 +/- 2.09 vs -3.72 +/- 2.43; P = 0.03), WC (cm) (-5.57 +/- 5.64 vs -2.32 +/- 5.95; P = 0.01) and WHR (-0.05 +/- 0.06 vs -0.02 +/- 0.07; P = 0.04). Furthermore, a greater change was found in hs-CRP levels (mg/L) (-2.06 +/- 1.18 vs -0.97 +/- 0.82; P = 0.03), prothrombin time (s) (1.41 +/- 2.34 vs -0.41 +/- 2.17; P < 0.001), activated partial thromboplastin time (s) (0.26 +/- 3.70 vs -1.78 +/- 3.56; P = 0.04) in modified alternate-day fasting diet when compared to calorie restriction diet. However, there was no difference in TNF-alpha or IL-6 and fibrinogen between groups (P > 0.05). Conclusions: These findings suggest that a modified alternate-day fasting diet can be a beneficial alternative for the management of body weight, fat mass and WC as well as hs-CRP and coagulation factors levels among metabolic syndrome patients.
C1 [Razavi, Roghaye; Parvaresh, Arefe; Yaghoobloo, Khadijeh; Safavi, Sayyed Morteza] Isfahan Univ Med Sci, Sch Nutr & Food Sci, Dept Clin Nutr, Esfahan, Iran.
   [Abbasi, Behnood] Islamic Azad Univ, Dept Nutr, Sci & Res Branch, Nutr, Tehran, Iran.
   [Hassanzadeh, Akbar] Isfahan Univ Med Sci, Sch Hlth, Dept Epidemiol & Biostat, Esfahan, Iran.
   [Mohammadifard, Noushin] Isfahan Univ Med Sci, Isfahan Cardiovasc Res Ctr, Cardiovasc Res Inst, Esfahan, Iran.
   [Clark, Cain C. T.] Coventry Univ, Fac Res Ctr Sport Exercise & Life Sci, Coventry, W Midlands, England.
C3 Isfahan University of Medical Sciences; Islamic Azad University; Isfahan
   University of Medical Sciences; Isfahan University of Medical Sciences;
   Coventry University
RP Safavi, SM (corresponding author), Isfahan Univ Med Sci, Sch Nutr & Food Sci, Dept Clin Nutr, Esfahan, Iran.
EM safavimorteza@yahoo.com
RI safavi, sayyed morteza/GLT-2139-2022; Clark, Cain/I-4480-2019; Abbasi,
   Behnood/K-6261-2018; Merat, Shahin/A-5478-2009; Abbasi,
   Behnood/H-1083-2016
OI Clark, Dr. Cain/0000-0002-6610-4617; Abbasi,
   Behnood/0000-0002-7684-3691; Razavi, Roghayeh/0000-0002-7081-4945
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NR 43
TC 42
Z9 43
U1 2
U2 7
PU IMR PRESS
PI ROBINSON
PA 112 ROBINSON RD, ROBINSON, SINGAPORE
SN 0300-9831
EI 1664-2821
J9 INT J VITAM NUTR RES
JI Int. J. Vitam. Nutr. Res.
PD MAY
PY 2021
VL 91
IS 3-4
BP 242
EP 250
DI 10.1024/0300-9831/a000623
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA WY8NE
UT WOS:000719533200008
PM 32003649
OA Green Submitted, Bronze
DA 2025-06-11
ER

PT J
AU Posa, DK
   Baba, SP
AF Posa, Dheeraj Kumar
   Baba, Shahid P.
TI Intracellular pH Regulation of Skeletal Muscle in the Milieu of Insulin
   Signaling
SO NUTRIENTS
LA English
DT Review
DE carnosine; chronic kidney disease; diabetes; glycolysis; histidyl
   dipeptides; insulin signaling; intracellular pH; obesity
ID HIGH-FAT DIET; CHRONIC KIDNEY-DISEASE; LOW URINE PH; OXIDATIVE STRESS;
   HEXOKINASE-II; GENE-EXPRESSION; GLUCOSE-TOLERANCE; ATHEROSCLEROSIS RISK;
   PROTEIN-METABOLISM; LACTATE TRANSPORT
AB Type 2 diabetes (T2D), along with obesity, is one of the leading health problems in the world which causes other systemic diseases, such as cardiovascular diseases and kidney failure. Impairments in glycemic control and insulin resistance plays a pivotal role in the development of diabetes and its complications. Since skeletal muscle constitutes a significant tissue mass of the body, insulin resistance within the muscle is considered to initiate the onset of diet-induced metabolic syndrome. Insulin resistance is associated with impaired glucose uptake, resulting from defective post-receptor insulin responses, decreased glucose transport, impaired glucose phosphorylation, oxidation and glycogen synthesis in the muscle. Although defects in the insulin signaling pathway have been widely studied, the effects of cellular mechanisms activated during metabolic syndrome that cross-talk with insulin responses are not fully elucidated. Numerous reports suggest that pathways such as inflammation, lipid peroxidation products, acidosis and autophagy could cross-talk with insulin-signaling pathway and contribute to diminished insulin responses. Here, we review and discuss the literature about the defects in glycolytic pathway, shift in glucose utilization toward anaerobic glycolysis and change in intracellular pH [pH](i) within the skeletal muscle and their contribution towards insulin resistance. We will discuss whether the derangements in pathways, which maintain [pH](i) within the skeletal muscle, such as transporters (monocarboxylate transporters 1 and 4) and depletion of intracellular buffers, such as histidyl dipeptides, could lead to decrease in [pH](i) and the onset of insulin resistance. Further we will discuss, whether the changes in [pH](i) within the skeletal muscle of patients with T2D, could enhance the formation of protein aggregates and activate autophagy. Understanding the mechanisms by which changes in the glycolytic pathway and [pH](i) within the muscle, contribute to insulin resistance might help explain the onset of obesity-linked metabolic syndrome. Finally, we will conclude whether correcting the pathways which maintain [pH](i) within the skeletal muscle could, in turn, be effective to maintain or restore insulin responses during metabolic syndrome.
C1 [Posa, Dheeraj Kumar; Baba, Shahid P.] Univ Louisville, Diabet & Obes Ctr, Louisville, KY 40202 USA.
   [Posa, Dheeraj Kumar; Baba, Shahid P.] Univ Louisville, Christina Lee Brown Envirome Inst, Louisville, KY 40202 USA.
C3 University of Louisville; University of Louisville
RP Posa, DK (corresponding author), Univ Louisville, Diabet & Obes Ctr, Louisville, KY 40202 USA.; Posa, DK (corresponding author), Univ Louisville, Christina Lee Brown Envirome Inst, Louisville, KY 40202 USA.
EM dheerajkumar.posa@louisville.edu; spbaba01@louisville.edu
OI Posa, Dheeraj kumar/0000-0003-0762-0280
FU National Institutes of Health [R01HL122581-01]
FX This work was supported by the National Institutes of Health:
   R01HL122581-01 (SPB).
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NR 122
TC 13
Z9 14
U1 0
U2 15
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD OCT
PY 2020
VL 12
IS 10
AR 2910
DI 10.3390/nu12102910
PG 15
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA OM6RK
UT WOS:000586149100001
PM 32977552
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Lee, DH
   Jacobs, DR
   Gross, M
   Kiefe, CI
   Roseman, J
   Lewis, CE
   Steffes, M
AF Lee, DH
   Jacobs, DR
   Gross, M
   Kiefe, CI
   Roseman, J
   Lewis, CE
   Steffes, M
TI γ-glutamyltransferase is a predictor of incident diabetes and
   hypertension:: The coronary artery risk development in young adults
   (CARDIA) study
SO CLINICAL CHEMISTRY
LA English
DT Article
ID INSULIN-RESISTANCE SYNDROME; TRANSPEPTIDASE; ASSOCIATION; IRON;
   DETERMINANTS; EXPRESSION; POPULATION; ALCOHOL; CELLS;
   GLUTAMYLTRANSFERASE
AB Background: gamma-Glutamyltransferase (GGT), which maintains cellular concentrations of glutathione, may be a marker of oxidative stress, and GGT itself may produce oxidative stress. We performed a prospective study to examine whether serum GGT predicts diabetes and hypertension.
   Methods: Study participants were 4844 black and white men and women 18-30 years of age in 1985-1986; they were reexamined 2, 5, 7, 10, and 15 years later. Year 0 GGT cutpoints were 12, 17, 25, and 36 U/L (overall 25th, 50th, 75th, and 90th percentiles; the laboratory cutpoints for abnormal are 40 U/L in women and 50 U/L in men). We deleted 32 participants with prevalent diabetes and 140 participants with prevalent hypertension from the respective incidence analyses.
   Results: After adjustment for study center, race, sex, and age in proportional hazards regression, the hazard ratios across year 0 GGT categories were 1.0. 1.6, 1.7, 4.0 (95% confidence interval, 2.0-8.1), and 5.5 (2.7-11.1) for 15-year incident diabetes and 1.0, 1.2, 1.7 (1.2-2.2), 2.3 (1.7-3.2). and 2.3 (1.7-3.2) for hypertension. Additional adjustment for year 0 alcohol consumption, body mass index, cigarette smoking, and physical activity attenuated this relationship, but GGT remained a significant predictor.
   Conclusions: Serum GGT within a range regarded as physiologically normal is associated with incident diabetes and hypertension. Considering known functionality of GGT, these associations are consistent with a role for oxidative stress in risk for diabetes and hypertension. (C) 2003 American Association for Clinical Chemistry.
C1 Univ Minnesota, Sch Publ Hlth, Div Epidemiol, Minneapolis, MN 55454 USA.
   Univ Minnesota, Sch Publ Hlth, Dept Lab Med & Pathol, Minneapolis, MN 55454 USA.
   Kosin Univ, Coll Med, Dept Prevent Med, Pusan 602202, South Korea.
   Univ Oslo, Inst Nutr Res, N-0316 Oslo, Norway.
   Univ Alabama, Div Prevent Med, Sch Med, Birmingham, AL 35205 USA.
   Univ Alabama, Dept Epidemiol, Sch Publ Hlth, Birmingham, AL 35205 USA.
   Vet Affairs Med Ctr, Birmingham, AL 35233 USA.
C3 University of Minnesota System; University of Minnesota Twin Cities;
   University of Minnesota System; University of Minnesota Twin Cities;
   University of Oslo; University of Alabama System; University of Alabama
   Birmingham; University of Alabama System; University of Alabama
   Birmingham; US Department of Veterans Affairs; Veterans Health
   Administration (VHA)
RP Jacobs, DR (corresponding author), Univ Minnesota, Sch Publ Hlth, Div Epidemiol, 1300 S 2nd St,Suite 300, Minneapolis, MN 55454 USA.
RI Jacobs, David/G-5405-2011
OI Jacobs, David/0000-0002-7232-0543
FU NHLBI NIH HHS [R01 HL053560, N01 HC 48050, R01 HL 53560, N01 HC 48049,
   N01 HC 48048, N01 HC 48047] Funding Source: Medline
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NR 32
TC 399
Z9 423
U1 0
U2 12
PU AMER ASSOC CLINICAL CHEMISTRY
PI WASHINGTON
PA 2101 L STREET NW, SUITE 202, WASHINGTON, DC 20037-1526 USA
SN 0009-9147
J9 CLIN CHEM
JI Clin. Chem.
PD AUG
PY 2003
VL 49
IS 8
BP 1358
EP 1366
DI 10.1373/49.8.1358
PG 9
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA 705CR
UT WOS:000184378900018
PM 12881453
OA Bronze
DA 2025-06-11
ER

PT J
AU He, QQ
   Tang, YG
   Li, YZ
   Wang, F
   Bao, JS
   Gupta, S
AF He, Qiqi
   Tang, Yangguo
   Li, Yuzhuo
   Wang, Fei
   Bao, Junsheng
   Gupta, Sanjay
TI A pilot dynamic analysis of formative factors of nephrolithiasis related
   to metabolic syndrome: evidence in a rat model
SO RENAL FAILURE
LA English
DT Article
DE Nephrolithiasis; metabolic syndrome; high oxalate urine; animal model
ID KIDNEY-STONE; OBESITY; RISK; MANIFESTATION; ASSOCIATION; COMPONENTS
AB Introduction and objective To examine the dynamic changes in the formative factors of nephrolithiasis and the final micromorphological changes in an obesity-initiated metabolic syndrome (MS) rat model. Methods Forty five-week-old male Sprague-Dawley (SD) rats were randomly divided into four groups: the regular diet group (RD), high-fat diet group (HFD), regular diet with drug (ethylene glycol and ammonium chloride) group (RDD), and high-fat diet with drug group (HFDD). A dynamic assessment of MS components (body weight (BW), body length (BL), Lee's index (LI), blood glucose (BG), total cholesterol (TC), and triglycerides (TGs)) and stone-forming factors (urinary pH, urinary calcium, and urinary oxalate acid) was carried out. In addition, the levels of oxidative stress (OS) markers (CAT, SOD, TAC, GSH-PX, and MDA) were measured, and histological analysis was carried out at the end of 16 weeks. Results MS-related parameters, such as BW, LI, BG, TC, and TG, were significantly higher in HFD-fed rats than in RD-fed rats (p < 0.001). In the HFDD group, significantly lower urinary pH, hyperoxaluria, and hypocalciuria were noted in the dynamic assessment of stone-forming factors (p < 0.001). CAT, TAC, and MDA were notably changed in the HFD-fed groups, particularly the HFDD rats. Histological analysis showed that the renal tubules of HFDD rats had the highest scores for both inflammation and renal crystallization deposition (p < 0.05). Conclusions Our results suggest that male SD rats with MS are prone to developing nephrolithiasis. Validation in an in vivo model may lead to an understanding of the underlying pathophysiological mechanisms of action of MS-related nephrolithiasis in humans. Key messages Male SD rats with metabolic syndrome are more prone to developing calcium oxalate nephrolithiasis after treatment with ethylene glycol and ammonium chloride compared to control lean rats. MS-related nephrolithiasis in rats induced by ethylene glycol and ammonium chloride is mainly related to increased hyperoxaluria and inflammation and decreased antioxidant levels. High-fat diet-fed SD rats treated with ethylene glycol and ammonium chloride are a stable and valid in vivo model for understanding the potential mechanism of action of MS-related nephrolithiasis.
C1 [He, Qiqi; Tang, Yangguo; Li, Yuzhuo; Bao, Junsheng] Lanzhou Univ, Hosp 2, Gansu Nephro Urol Clin Ctr, Dept Urol,Key Lab Dis Urol Syst, 80 Cui YinMen St, Lanzhou 730030, Gansu, Peoples R China.
   [Tang, Yangguo] Guangxi Univ, Coll Anim Sci & Technol, Nanning, Peoples R China.
   [Wang, Fei] Lanzhou Univ, Hosp 2, Dept Paediat, Lanzhou, Peoples R China.
   [Gupta, Sanjay] Case Western Reserve Univ, Case Med Ctr, Univ Hosp, Dept Urol, Cleveland, OH 44106 USA.
C3 Lanzhou University; Guangxi University; Lanzhou University; University
   System of Ohio; Case Western Reserve University; University Hospitals of
   Cleveland
RP He, QQ (corresponding author), Lanzhou Univ, Hosp 2, Gansu Nephro Urol Clin Ctr, Dept Urol,Key Lab Dis Urol Syst, 80 Cui YinMen St, Lanzhou 730030, Gansu, Peoples R China.
EM ery_heqq@lzu.edu.cn
FU National Natural Science Foundation of China [81800671]; Cuiyin Talent
   Program [CY2021-MS-A02]; Gansu Health industry Scientific Research
   Program [GSWSKY2021-070]; Lanzhou Science & Technology Project
   [2022-ZD-105]
FX This work was supported by the National Natural Science Foundation of
   China [81800671], Cuiyin Talent Program [CY2021-MS-A02], Gansu Health
   industry Scientific Research Program [GSWSKY2021-070] and Lanzhou
   Science & Technology Project [2022-ZD-105].
CR Abate N, 2004, KIDNEY INT, V65, P386, DOI 10.1111/j.1523-1755.2004.00386.x
   Ahmed OM, 2020, BIOMOLECULES, V10, DOI 10.3390/biom10091317
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NR 25
TC 2
Z9 2
U1 1
U2 14
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0886-022X
EI 1525-6049
J9 RENAL FAILURE
JI Ren. Fail.
PD DEC 31
PY 2022
VL 44
IS 1
BP 1134
EP 1143
DI 10.1080/0886022X.2022.2097922
PG 10
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 2Y5RA
UT WOS:000825952800001
PM 35837686
OA Green Published
DA 2025-06-11
ER

PT J
AU Krishnaveni, GV
   Veena, SR
   Johnson, M
   Kumaran, K
   Jones, A
   Bhat, DS
   Yajnik, CS
   Fall, CHD
AF Krishnaveni, Ghattu, V
   Veena, Sargoor R.
   Johnson, Matt
   Kumaran, Kalyanaraman
   Jones, Alexander
   Bhat, Dattatray S.
   Yajnik, Chittaranjan S.
   Fall, Caroline H. D.
TI Maternal B12, Folate and Homocysteine Concentrations and Offspring
   Cortisol and Cardiovascular Responses to Stress
SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Article
DE B12 deficiency; folate; homocysteine; stress response; cortisol;
   adolescent
ID FOLIC-ACID; BIRTH-WEIGHT; MICROBIOLOGICAL ASSAY; VITAMIN-B-12 STATUS;
   INSULIN-RESISTANCE; COGNITIVE FUNCTION; MENTAL STRESS; PREGNANCY; RISK;
   NUTRITION
AB Context: Imbalances in maternal 1-carbon nutrients (vitamin B12, folate) have been shown to be associated with higher offspring cardiometabolic risk markers in India.
   Objective: We examined the hypothesis that low plasma vitamin B12 (B12) and high folate and homocysteine concentrations in the mother are associated with higher hypothalamic-pituitary-adrenal axis (cortisol) and cardiovascular responses during the Trier Social Stress Test for Children (TSST-C) in an Indian birth cohort.
   Methods: Adolescents (n = 264; mean age: 13.6 years), whose mothers' plasma B12, folate and total homocysteine concentrations had been measured during pregnancy, completed 5-minutes each of public speaking and mental arithmetic tasks in front of 2 unfamiliar "judges" (TSST-C). Baseline and poststress salivary cortisol concentrations were measured. Heart rate, blood pressure, stroke volume, cardiac output, and total peripheral resistance were measured continuously at baseline, during the TSST-C, and for 10 minutes after the TSST-C using a finger cuff; beat-to-beat values were averaged for these periods, respectively.
   Results: Maternal low B12 status (plasma B12 < 150 pmol/L) was associated with greater cortisol responses to stress in the offspring (P < .001). Higher homocysteine concentrations were associated with greater offspring heart rate response (P < .001). After adjustment for multiple comparisons, there were nonsignificant associations between higher maternal folate concentrations and offspring total peripheral resistance response (P = .01).
   Conclusion: Our findings suggest that maternal 1-carbon nutritional status may have long-term programming implications for offspring neuroendocrine stress responses.
C1 [Krishnaveni, Ghattu, V; Veena, Sargoor R.; Kumaran, Kalyanaraman] CSI Holdsworth Mem Hosp, Epidemiol Res Unit, Mysore, Karnataka, India.
   [Johnson, Matt; Kumaran, Kalyanaraman; Fall, Caroline H. D.] Southampton Gen Hosp, MRC, Lifecourse Epidemiol Unit, Southampton, Hants, England.
   [Jones, Alexander] Univ Oxford, Dept Paediat, Oxford, England.
   [Bhat, Dattatray S.; Yajnik, Chittaranjan S.] King Edward Mem Hosp & Res Ctr, Diabet Unit, Pune, Maharashtra, India.
C3 University of Southampton; University of Oxford
RP Krishnaveni, GV (corresponding author), CSI Holdsworth Mem Hosp, Post Box 38, Mysore 570001, Karnataka, India.
EM gv.krishnaveni@gmail.com
RI Kumaran, Kalyanaraman/KCK-5741-2024
OI Krishnaveni, Ghattu V/0000-0002-6532-8272
FU Wellcome Trust UK [095147/Z/1O/Z]; Parthenon Trust; Wellcome Trust;
   Medical Research Council (UK); Department for International Development
   (UK); Wellcome Trust-DBT India Alliance Senior Fellowship; MRC
   [G0400519, MC_UU_12011/3, MC_PC_MR/R018545/1, MC_UP_A620_1016,
   MC_U147585821] Funding Source: UKRI
FX The study was supported by the Wellcome Trust UK as part of a personal
   fellowship to GVK (095147/Z/1O/Z). The Parthenon Cohort was funded by
   the Parthenon Trust, the Wellcome Trust, the Medical Research Council
   (UK) and the Department for International Development (UK). GVK is
   currently supported by a Wellcome Trust-DBT India Alliance Senior
   Fellowship.
CR [Anonymous], 2001, National Family Health Survey (NFHS-2), 1998-99
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NR 33
TC 6
Z9 6
U1 1
U2 5
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0021-972X
EI 1945-7197
J9 J CLIN ENDOCR METAB
JI J. Clin. Endocrinol. Metab.
PD JUL
PY 2020
VL 105
IS 7
BP E2591
EP E2599
DI 10.1210/clinem/dgz114
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA NJ3BF
UT WOS:000565922200029
PM 32206806
OA Green Published, Green Accepted, hybrid
DA 2025-06-11
ER

PT J
AU Weigensberg, MJ
   Wen, CKF
   Sanogo, F
   Toledo-Corral, C
   Ding, L
AF Weigensberg, Marc J.
   Wen, Cheng K. F.
   Sanogo, Fatimata
   Toledo-Corral, Claudia
   Ding, Li
TI Imagine HEALTH: Changes in diurnal salivary cortisol patterns following
   a 12-week guided imagery RCT lifestyle intervention in predominantly
   Latino adolescents
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE Guided imagery; Adolescents; Latino; Obesity; Stress reduction; Cortisol
ID PITUITARY-ADRENAL AXIS; METABOLIC SYNDROME; AWAKENING RESPONSE;
   STRESS-REDUCTION; HIGH-SCHOOL; OVERWEIGHT; CHILDREN; NEUROENDOCRINE;
   ASSOCIATION; DEPRESSION
AB Objective: Alterations in diurnal salivary cortisol patterns have been linked to adverse metabolic health outcomes. We have previously shown that stress-reduction guided imagery (GI) can reduce salivary cortisol levels acutely. We now ask whether addition of GI into a 12-week lifestyle intervention designed to improve eating and physical activity behaviors can alter diurnal salivary cortisol patterns and perceived stress.Methods: 232 adolescent participants (ages 14-17 years) were cluster randomized by school into one of four intervention arms: non-intervention Control (C; n = 51), Lifestyle (LS; n=61), Stress-Reduction GI (SRGI; n = 55), and Lifestyle Behavior GI (LBGI; n = 65). LS group received one nutrition and one physical activity class per week after-school for 12 weeks. SRGI and LBGI groups received same LS classes plus an additional weekly GI session. Salivary cortisol was assessed pre-and post-intervention on 3 days, 3 times daily, at awakening, 30 -mi-nutes post-awakening, and in the evening to determine Cortisol Awakening Response (CAR) and Diurnal Cortisol Slope (DCS). Perceived Stress Scale (PSS) was administered pre-and post-intervention. Mixed effects modeling was used for intent-to-treat analysis and sensitivity analysis was used for those participants adherent to inter-vention protocol. Results: Analysis of 208 subjects with complete data showed a small between-group increase in CAR in LBGI vs C (p = 0.045, d=0.24), with no significant group differences among other intervention arms. There were no be-tween group differences in change in DCS or change in PSS after 12-weeks. Amongst adherent participants, LBGI showed a small-moderate increase in CAR (p = 0.03, d=0.37), and moderate-large reduction in PSS (p = 0.02, d=-0.66) compared to C. There were no other between group differences in CAR, DCS, or PSS.Conclusion: LBGI led to an increase in CAR, and in adherent subjects, a decrease in PSS, suggesting GI may be a mind-body intervention that can affect both objective and subjective measures of the stress response. Whether changes in cortisol patterns in this population affect measures of mental or physical health remains to be determined.
C1 [Weigensberg, Marc J.] USC Keck Sch Med, Dept Pediat, Los Angeles, CA 90033 USA.
   [Wen, Cheng K. F.] USC Ctr Self Report Sci, Los Angeles, CA USA.
   [Sanogo, Fatimata] USC Keck Sch Med, Dept Populat & Publ Hlth Sci, Los Angeles, CA USA.
   [Toledo-Corral, Claudia] Calif State Univ Northridge, Dept Hlth Sci, Northridge, CA USA.
   [Ding, Li] USC Keck Sch Med, Dept Populat & Publ Hlth Sci, Div Biostat, Los Angeles, CA USA.
C3 University of Southern California; University of Southern California;
   California State University System; California State University
   Northridge; University of Southern California
RP Weigensberg, MJ (corresponding author), USC Keck Sch Med, Dept Pediat, Los Angeles, CA 90033 USA.
EM weigensb@usc.edu
RI Toledo-Corral, Claudia/J-5299-2019; Ding, Li/G-4031-2019; Wen,
   Cheng/J-6672-2019
OI Wen, Cheng K. Fred/0000-0002-2538-0439
FU NIH National Center for Complementary and Integrative Health
   [R01AT008330, UL1TR001855, UL1TR000130]
FX Funding: This work was sponsored by NIH National Center for
   Complementary and Integrative Health, R01AT008330. This work was
   supported by grants UL1TR001855 and UL1TR000130 from the
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NR 65
TC 1
Z9 1
U1 2
U2 5
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
EI 1873-3360
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD MAY
PY 2023
VL 151
AR 106053
DI 10.1016/j.psyneuen.2023.106053
EA FEB 2023
PG 9
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA 9W4CJ
UT WOS:000949025800001
PM 36842257
OA Bronze
DA 2025-06-11
ER

PT J
AU Lee, DH
   Ha, MH
   Kim, JH
   Christiani, DC
   Gross, MD
   Steffes, M
   Blomhoff, R
   Jacobs, DR
AF Lee, DH
   Ha, MH
   Kim, JH
   Christiani, DC
   Gross, MD
   Steffes, M
   Blomhoff, R
   Jacobs, DR
TI Gamma-glutamyltransferase and diabetes - a 4 year follow-up study
SO DIABETOLOGIA
LA English
DT Article
DE gamma glutamyltransferase; obesity; age; diabetes
ID OXIDATIVE STRESS; TRANSPEPTIDASE; DETERMINANTS; ASSOCIATION; POPULATION;
   EXPRESSION; ALCOHOL; MORTALITY; RADICALS; DISEASE
AB Aims/Hypothesis. Gamma-glutamyltransferase (GGT) is located on the external surface of most cells and mediates the uptake of gluthathione, an important component of intracellular antioxidant defenses. An increase in GGT concentration has been regarded as a marker of alcohol consumption or liver disease. However, more subtle gradations in GGT could be informative because its expression is enhanced by oxidative stress and it could be released by several conditions inducing cellular stress. Recently, serum GGT concentrations have been associated with many cardiovascular disease risk factors or components of the insulin resistance syndrome. We did a prospective study with the hypothesis that serum GGT is a predictor of incident diabetes.
   Methods. A total of 4,088 healthy men working in a steel manufacturing company were examined in 1994 and 1998. Diabetes was defined as a serum fasting glucose concentration of more than 126 mg/dl or the use of diabetes medication.
   Results. There was a strong dose-response relation between serum GGT concentrations at baseline and the incidence of diabetes. In contrast to the 31% of men with GGT concentrations under 9 U/l, adjusted relative risks for incidence of diabetes for GGT concentrations 10-19, 20-29, 30-39, 40-49, and over 50 U/l were 8.0, 13.3, 12.6, 19.6 and 25.8, respectively. The associations of age and BMI with incident diabetes became stronger the higher the value of baseline serum GGT concentration.
   Conclusion/interpretation. This study suggests that an increase in GGT concentration within its physiological range is a sensitive and early biomarker for the development of diabetes.
C1 Kosin Univ, Dept Prevent Med, Suh Gu, Pusan 602702, South Korea.
   Pohang Steel Co, Hlth Care Ctr, Pohang, South Korea.
   Harvard Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA 02115 USA.
   Univ Minnesota, Sch Publ Hlth, Dept Lab Med, Minneapolis, MN 55455 USA.
   Univ Minnesota, Sch Publ Hlth, Div Epidemiol, Minneapolis, MN 55455 USA.
   Univ Oslo, Inst Nutr Res, Oslo, Norway.
   Univ Minnesota, Sch Publ Hlth, Div Epidemiol, Minneapolis, MN 55455 USA.
C3 Harvard University; Harvard T.H. Chan School of Public Health;
   University of Minnesota System; University of Minnesota Twin Cities;
   University of Minnesota System; University of Minnesota Twin Cities;
   University of Oslo; University of Minnesota System; University of
   Minnesota Twin Cities
RP Kosin Univ, Dept Prevent Med, Suh Gu, 34 Amnan Dong, Pusan 602702, South Korea.
EM ducky@ns.kosinmed.or.kr
RI Jacobs, David/G-5405-2011
OI Jacobs, David/0000-0002-7232-0543
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NR 29
TC 274
Z9 295
U1 0
U2 11
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0012-186X
EI 1432-0428
J9 DIABETOLOGIA
JI Diabetologia
PD MAR
PY 2003
VL 46
IS 3
BP 359
EP 364
DI 10.1007/s00125-003-1036-5
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 674CV
UT WOS:000182620000007
PM 12687334
OA Bronze
DA 2025-06-11
ER

PT J
AU Panazzolo, DG
   Sicuro, FL
   Clapauch, R
   Maranhao, PA
   Bouskela, E
   Kraemer-Aguiar, LG
AF Panazzolo, Diogo G.
   Sicuro, Fernando L.
   Clapauch, Ruth
   Maranhao, Priscila A.
   Bouskela, Eliete
   Kraemer-Aguiar, Luiz G.
TI Obesity, metabolic syndrome, impaired fasting glucose, and microvascular
   dysfunction: a principal component analysis approach
SO BMC CARDIOVASCULAR DISORDERS
LA English
DT Article
DE Microcirculation; Capillaries; Obesity; Metabolic syndrome; Impaired
   fasting glucose; Principal component analysis
ID ACUTE CORONARY SYNDROMES; ENDOTHELIAL DYSFUNCTION; INSULIN-RESISTANCE;
   NORMOGLYCEMIC SUBJECTS; WAIST CIRCUMFERENCE; ASSOCIATION; ADOLESCENTS;
   GLYCOCALYX; HORMONE; STRESS
AB Background: We aimed to evaluate the multivariate association between functional microvascular variables and clinical-laboratorial-anthropometrical measurements.
   Methods: Data from 189 female subjects (34.0 +/- 15.5 years, 30.5 +/- 7.1 kg/m(2)), who were non-smokers, non-regular drug users, without a history of diabetes and/or hypertension, were analyzed by principal component analysis (PCA). PCA is a classical multivariate exploratory tool because it highlights common variation between variables allowing inferences about possible biological meaning of associations between them, without pre-establishing cause-effect relationships. In total, 15 variables were used for PCA: body mass index (BMI), waist circumference, systolic and diastolic blood pressure (BP), fasting plasma glucose, levels of total cholesterol, high-density lipoprotein cholesterol (HDL-c), low-density lipoprotein cholesterol (LDL-c), triglycerides (TG), insulin, C-reactive protein (CRP), and functional microvascular variables measured by nailfold videocapillaroscopy. Nailfold videocapillaroscopy was used for direct visualization of nutritive capillaries, assessing functional capillary density, red blood cell velocity (RBCV) at rest and peak after 1 min of arterial occlusion (RBCVmax), and the time taken to reach RBCVmax (TRBCVmax).
   Results: A total of 35% of subjects had metabolic syndrome, 77% were overweight/obese, and 9.5% had impaired fasting glucose. PCA was able to recognize that functional microvascular variables and clinical-laboratorial-anthropometrical measurements had a similar variation. The first five principal components explained most of the intrinsic variation of the data. For example, principal component 1 was associated with BMI, waist circumference, systolic BP, diastolic BP, insulin, TG, CRP, and TRBCVmax varying in the same way. Principal component 1 also showed a strong association among HDL-c, RBCV, and RBCVmax, but in the opposite way. Principal component 3 was associated only with microvascular variables in the same way (functional capillary density, RBCV and RBCVmax). Fasting plasma glucose appeared to be related to principal component 4 and did not show any association with microvascular reactivity.
   Conclusions: In non-diabetic female subjects, a multivariate scenario of associations between classic clinical variables strictly related to obesity and metabolic syndrome suggests a significant relationship between these diseases and microvascular reactivity.
C1 [Panazzolo, Diogo G.; Sicuro, Fernando L.; Clapauch, Ruth; Maranhao, Priscila A.; Bouskela, Eliete; Kraemer-Aguiar, Luiz G.] Univ Estado Rio De Janeiro, Biomed Ctr, Clin & Expt Res Lab Vasc Biol BioVasc, Rio De Janeiro, Brazil.
   [Clapauch, Ruth] Hosp Lagoa, Female Endocrinol Sect, Minist Hlth, Rio De Janeiro, Brazil.
   [Kraemer-Aguiar, Luiz G.] Univ Estado Rio De Janeiro, Dept Internal Med, Fac Med Sci, Div Endocrinol, Rio De Janeiro, Brazil.
C3 Universidade do Estado do Rio de Janeiro; Universidade do Estado do Rio
   de Janeiro
RP Kraemer-Aguiar, LG (corresponding author), Univ Estado Rio De Janeiro, Biomed Ctr, Clin & Expt Res Lab Vasc Biol BioVasc, Rio De Janeiro, Brazil.
EM gkraemer@ig.com.br
RI Clapauch, Ruth/IUP-4139-2023; Maranhão, Priscila/F-2624-2013; Sicuro,
   Fernando/ABB-5797-2020; Kraemer-Aguiar, Luiz Guilherme/ABG-2833-2022
OI Sicuro, Fernando/0000-0002-2091-1712; Kraemer-Aguiar, Luiz
   Guilherme/0000-0002-3528-5881; Maranhao, Priscila/0000-0002-4804-4999
FU National Research Council of Brazil (CNPq); Agency for Financing
   Research of the State of Rio de Janeiro (FAPERJ)
FX This study was supported by grants from the National Research Council of
   Brazil (CNPq) and the Agency for Financing Research of the State of Rio
   de Janeiro (FAPERJ).
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NR 39
TC 14
Z9 16
U1 0
U2 10
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1471-2261
J9 BMC CARDIOVASC DISOR
JI BMC Cardiovasc. Disord.
PD NOV 13
PY 2012
VL 12
AR 102
DI 10.1186/1471-2261-12-102
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 062GZ
UT WOS:000312908800001
PM 23148545
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Birarra, MK
   Gelayee, DA
AF Birarra, Mequanent Kassa
   Gelayee, Dessalegn Asmelashe
TI Metabolic syndrome among type 2 diabetic patients in Ethiopia: a
   cross-sectional study
SO BMC CARDIOVASCULAR DISORDERS
LA English
DT Article
DE Metabolic syndrome; Type 2 diabetes mellitus; University of Gondar;
   Ethiopia
ID CARDIOVASCULAR-DISEASE; PREVALENCE; RISK; DIAGNOSIS; STRESS; ADULTS
AB Background: Metabolic syndrome (MetS) increases risk of cardiovascular diseases (CVD), premature death as well as cost related to health care. This study was aimed at investigating the prevalence of MetS and its determinant factors among type2 diabetes mellitus (T2DM) patients attending a specialized hospital.
   Methods: A cross-sectional study was conducted on a total of 256 T2DM patients from the first march to 30th May 2017 at university of gondar comprehensive specialized hospital (UGCSH). Data was collected based on STROBE (strengthening the reporting of observational studies in epidemiology) statement. Bivariable and multivariable logistic regression analysis were run to identify predictors of MetS from the independent variables and significance test was set at P < 0.05.
   Results: The prevalence of MetS in this study was 70.3, 57 & 45.3% and it is more common in females (66.1, 83.3 & 70.7%) by using national cholesterol education program adult treatment panel III (NCEP-ATP III), International diabetic federation (IDF) and world health organization (WHO) criteria respectively. The most prevalent components of MetS were low level of high density lipoprotein (HDL) and triglyceride(TG). By usingIDF criteria, female gender was significantly associated with MetS (AOR = 0.2 at 95% CI: 0.1, 0.6 P = 0.00). Where as by NCEP-ATP IIIcriteria, age between 51 and 64 years old (AOR = 2.4 95% CI: 1.0,5.8, P = 0.04), self employment (AOR = 2.7 95% CI: 1.1, 6.5, P = 0. 03), and completetion of secondary school and above (AOR = 3.2, 95% CI: 1.6,6.7, P = 0.001) were predictors for the development of MetS. In the WHO criteria, being single in marital status was significantly associated with MetS (AOR = 17 at 95% CI: 1.8, 166, P = 0.000).
   Conclusions: This study demonstrates that Metabolic syndrome is a major health concern for diabetic patients in Ethiopia and they are at increased risk of developing complications such as cardiovascular diseases and premature mortality. The predictors female gender, age between 51 and 64 years old, urban area residence, and being single are modifiable. Thus, health authorities shall provide targeted interventions such as life style modifications to these most at risk sub-populations of diabetic patients.
C1 [Birarra, Mequanent Kassa] Univ Gondar, Coll Med & Hlth Sci, Sch Pharm, Dept Clin Pharm, Lideta St,POB 196, Gondar, Ethiopia.
   [Gelayee, Dessalegn Asmelashe] Univ Gondar, Coll Med & Hlth Sci, Sch Pharm, Dept Pharmacol, Gondar, Ethiopia.
C3 University of Gondar; University of Gondar
RP Birarra, MK (corresponding author), Univ Gondar, Coll Med & Hlth Sci, Sch Pharm, Dept Clin Pharm, Lideta St,POB 196, Gondar, Ethiopia.
EM mekuanentk@gmail.com
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NR 44
TC 29
Z9 29
U1 1
U2 18
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1471-2261
J9 BMC CARDIOVASC DISOR
JI BMC Cardiovasc. Disord.
PD JUL 17
PY 2018
VL 18
AR 149
DI 10.1186/s12872-018-0880-7
PG 12
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA GN3SS
UT WOS:000438929000001
PM 30016936
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Pizzi, C
   Manfrini, O
   Fontana, F
   Bugiardini, R
AF Pizzi, C
   Manfrini, O
   Fontana, F
   Bugiardini, R
TI Angiotensin-converting enzyme inhibitors and 3-hydroxy-3-methylglutaryl
   coenzyme A reductase in cardiac syndrome X - Role of superoxide
   dismutase activity
SO CIRCULATION
LA English
DT Article
DE syndrome X; endothelium; free radicals
ID NORMAL CORONARY-ARTERIES; CHEST-PAIN; NITRIC-OXIDE; ENDOTHELIAL
   DYSFUNCTION; FLOW RESERVE; DISEASE; ANGINA; VASODILATATION; ANGIOGRAMS;
   MECHANISMS
AB Background - Morbidity of patients with Syndrome X (SX; chest pain and normal coronary angiograms) is high and is associated with continuing episodes of chest pain and hospitalization. Impairment of microvascular endothelial function caused by increased oxidative stress has been suggested to be a mechanism of the disease. Superoxide dismutase ( SOD) is the major antioxidant enzyme system of the vascular wall. This study sought to establish whether combination treatment with ACE inhibitors and statins reduces oxidative stress and improves quality of life of patients with cardiac SX.
   Methods and Results - Forty-five patients with SX were randomly assigned to receive either a combination of ramipril (10 mg/d) and atorvastatin ( 40 mg/d) or placebo for 6 months. We determined the activity of extracellular SOD and its relation to flow-dependent endothelium-mediated dilation (FMD) and quality of life ( exercise capacity and score with Seattle Angina Questionnaire [SAQ]) before and after treatment. After 6 months, patients with SX who received atorvastatin and ramipril had significantly reduced ( P = 0.001) SOD levels (188.1 +/- 29.6 U/mL). No significant changes were seen on placebo (262.9 +/- 48.8 U/mL). Reduction of SOD after therapy was negatively correlated with FMD (r = 0.38; P = 0.01) and positively with total cholesterol (r = - 0.56; P < 0.001). At follow-up, patients taking atorvastatin and ramipril improved their quality of life both in terms of exercise duration (by 23.46%) and SAQ (by 64.1%).
   Conclusions - Six months of therapy with atorvastatin and ramipril improves endothelial function and quality of life of patients with SX. Reduced SOD activity may reflect low superoxide anion production. Benefits of these drugs may be related to reduction of oxidative stress.
C1 Univ Bologna, Dipartimento Med Interna, I-40138 Bologna, Italy.
C3 University of Bologna
RP Bugiardini, R (corresponding author), Univ Bologna, Dipartimento Med Interna, Via Massarenti 9, I-40138 Bologna, Italy.
RI PIZZI, Carmine/C-8394-2012; MANFRINI, OLIVIA/AAM-9442-2020; Bugiardini,
   Raffaele/L-6446-2015
OI Bugiardini, Raffaele/0000-0002-6819-6818; Pizzi,
   Carmine/0000-0002-4048-675X
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NR 28
TC 147
Z9 152
U1 0
U2 7
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0009-7322
J9 CIRCULATION
JI Circulation
PD JAN 6
PY 2004
VL 109
IS 1
BP 53
EP 58
DI 10.1161/01.CIR.0000100722.34034.E4
PG 6
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 760BY
UT WOS:000187791900013
PM 14699004
OA Bronze
DA 2025-06-11
ER

PT J
AU Jibril, AT
   Jayedi, A
   Shab-Bidar, S
AF Jibril, Aliyu Tijani
   Jayedi, Ahmad
   Shab-Bidar, Sakineh
TI Efficacy and safety of oral alpha-lipoic acid supplementation for type 2
   diabetes management: a systematic review and dose-response meta-analysis
   of randomized trials
SO ENDOCRINE CONNECTIONS
LA English
DT Review
DE alpha-lipoic acid; cardiometabolic; type 2 diabetes; diabetes;
   systematic review; meta-analysis
ID CARDIAC AUTONOMIC NEUROPATHY; OXIDATIVE-STRESS; GLUCOSE-UPTAKE;
   ANTIOXIDANT; ACTIVATION; MELLITUS; ALA; WEIGHT; NIDDM
AB Objective: To examine the dose-dependent influence of oral alpha-lipoic acid (ALA) supplementation on cardiometabolic risk factors in patients with type 2 diabetes (T2D).
   Design: We followed the instructions outlined in the Cochrane Handbook for Systematic Reviews of Interventions and the Grading of Recommendations, Assessment, Development, and Evaluation Handbook to conduct our systematic review. The protocol of the study was registered in PROSPERO (CRD42021260587).
   Method: We searched PubMed, Scopus, and Web of Science to May 2021 for trials of oral ALA supplementation in adults with T2D. The primary outcomes were HbA1c, weight loss, and LDL cholesterol (LDL-C). Secondary outcomes included fasting plasma glucose (FPG), triglyceride (TG), C-reactive protein (CRP), and blood pressure. We conducted a random-effects dose-response meta-analysis to calculate the mean difference (MD) and 95% CI for each 500 mg/day oral ALA supplementation. We performed a nonlinear dose-response meta-analysis using a restricted cubic spline.
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   Conclusion: Despite significant improvements, the effects of oral ALA supplementation on cardiometabolic risk factors in patients with T2D were not clinically important.
C1 [Jibril, Aliyu Tijani; Shab-Bidar, Sakineh] Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Community Nutr, Tehran, Iran.
   [Jayedi, Ahmad] Semnan Univ Med Sci, Social Determinants Hlth Res Ctr, Semnan, Iran.
C3 Tehran University of Medical Sciences; Semnan University of Medical
   Sciences
RP Shab-Bidar, S (corresponding author), Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Community Nutr, Tehran, Iran.
EM s_shabbidar@tums.ac.ir
RI Jayedi, Ahmad/E-7237-2017; Shab-Bidar, Sakineh/H-9525-2017; Jibril,
   Aliyu Tijani/AAF-4695-2021
OI Jibril, Aliyu Tijani/0000-0003-3930-9091
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NR 70
TC 7
Z9 7
U1 0
U2 2
PU BIOSCIENTIFICA LTD
PI BRISTOL
PA STARLING HOUSE, 1600 BRISTOL PARKWAY N, BRISTOL, ENGLAND
EI 2049-3614
J9 ENDOCR CONNECT
JI Endocr. Connect.
PD OCT 1
PY 2022
VL 11
IS 10
AR e220322
DI 10.1530/EC-22-0322
PG 14
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 5K4SF
UT WOS:000869716800006
PM 36006850
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Hristov, BD
AF Hristov, Boris D.
TI The Role of Glutathione Metabolism in Chronic Illness Development and
   Its Potential Use as a Novel Therapeutic Target
SO CUREUS JOURNAL OF MEDICAL SCIENCE
LA English
DT Review
DE atherosclerotic cardiovascular disease; neurodegenerative disesase;
   chronic liver disease (cld); chronic renal disease; metabolic syndrome;
   ggt; n-acetylcysteine; glutathione
ID INTRAVENOUS N-ACETYLCYSTEINE; GAMMA-GLUTAMYL-TRANSFERASE; OXIDATIVE
   STRESS; CARDIOVASCULAR-DISEASE; ACETYL-CYSTEINE; RISK; TRANSPEPTIDASE;
   HOMOCYSTEINE; MULTICENTER; ELEVATION
AB Glutathione (GSH) is the most abundant thiol antioxidant in the human body and serves many important biochemical functions, including the regulation of vitamins, such as vitamins D, E, and C, and detoxification of drugs and toxins. As a powerful antioxidant, GSH is particularly important as a regulator of mitochondrial metabolism and a free radical scavenger that limits oxidative damage to cellular components. Low GSH levels have been associated with many chronic pro-inflammatory conditions, such as metabolic syndrome, cardiovascular, renal, and hepatic disease, as well as neurodegenerative conditions and autoimmune diseases. Given GSH's known direct protective role in mitochondrial metabolism and its association with chronic diseases of highly metabolically active tissues, this review aims to examine the literature for evidence that low GSH levels may be an important causative factor in the development of chronic illnesses. Because no large prospective human trials have been conducted using direct measurements of GSH, this review focused on the more common biomarker gamma-glutamyl transferase (GGT) which is directly correlated to low GSH levels. Several large prospective studies support this hypothesis by demonstrating that higher GGT levels are correlated with the risk of developing metabolic syndrome and cardiovascular disease in a dose-dependent fashion. Furthermore, as a corollary to this hypothesis, human and animal trials utilizing GSH augmentation using precursor supplementation in chronic conditions, including metabolic syndrome, cardiovascular disease, hepatic disease, renal disease, and neurodegenerative conditions, were also reviewed. While many of these trials were preliminary and small, there is strong evidence that GSH supplementation leads to improved outcomes in all of these chronic conditions. This review seeks to highlight these studies as preliminary evidence demonstrating the contributory role of GSH in chronic disease progression because a simple and cost-effective strategy can be created to screen for, track, and intervene in susceptible patients in the primary care setting at the earliest possible time in the disease process. Such a novel strategy would impact the majority of chronic diseases contributing to the bulk of morbidity and mortality in the Western world, and, thus, even minor benefits across many conditions may substantially impact population-wide health and longevity.
C1 [Hristov, Boris D.] Brookdale Univ Hosp Med Ctr, Surg Crit Care & Acute Care Surg, New York, NY 11212 USA.
RP Hristov, BD (corresponding author), Brookdale Univ Hosp Med Ctr, Surg Crit Care & Acute Care Surg, New York, NY 11212 USA.
EM bhristov10@gmail.com
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NR 61
TC 18
Z9 19
U1 0
U2 5
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
EI 2168-8184
J9 CUREUS J MED SCIENCE
JI Cureus J Med Sci
PD SEP 28
PY 2022
VL 14
IS 9
AR e29696
DI 10.7759/cureus.29696
PG 8
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA 6J0PB
UT WOS:000886529200045
PM 36321012
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Laurent, MR
   Cook, MJ
   Gielen, E
   Ward, KA
   Antonio, L
   Adams, JE
   Decallonne, B
   Bartfai, G
   Casanueva, FF
   Forti, G
   Giwercman, A
   Huhtaniemi, IT
   Kula, K
   Lean, MEJ
   Lee, DM
   Pendleton, N
   Punab, M
   Claessens, F
   Wu, FCW
   Vanderschueren, D
   Pye, SR
   O'Neill, TW
AF Laurent, M. R.
   Cook, M. J.
   Gielen, E.
   Ward, K. A.
   Antonio, L.
   Adams, J. E.
   Decallonne, B.
   Bartfai, G.
   Casanueva, F. F.
   Forti, G.
   Giwercman, A.
   Huhtaniemi, I. T.
   Kula, K.
   Lean, M. E. J.
   Lee, D. M.
   Pendleton, N.
   Punab, M.
   Claessens, F.
   Wu, F. C. W.
   Vanderschueren, D.
   Pye, S. R.
   O'Neill, T. W.
CA EMAS Grp
TI Lower bone turnover and relative bone deficits in men with metabolic
   syndrome: a matter of insulin sensitivity? The European Male Ageing
   Study
SO OSTEOPOROSIS INTERNATIONAL
LA English
DT Article
DE Bone mineral density; Bone turnover; Male; Metabolic syndrome; Obesity;
   Peripheral quantitative computed tomography
ID BODY-MASS INDEX; FRACTURE RISK; MINERAL DENSITY; SEX STEROIDS;
   ELDERLY-MEN; OLDER MEN; WOMEN; ASSOCIATION; COHORT; HEALTH
AB We examined cross-sectional associations of metabolic syndrome and its components with male bone turnover, density and structure. Greater bone mass in men with meta-bolic syndrome was related to their greater body mass, whereas hyperglycaemia, hypertriglyceridaemia or impaired insulin sensitivity were associated with lower bone turnover and relative bone mass deficits.
   Introduction Metabolic syndrome (MetS) has been associated with lower bone turnover and relative bone mass or strength deficits (i.e. not proportionate to body mass index, BMI), but the relative contributions of MetS components related to insulin sensitivity or obesity to male bone health remain unclear.
   Methods We determined cross-sectional associations of MetS, its components and insulin sensitivity (by homeostatic model assessment-insulin sensitivity (HOMA-S)) using linear regression models adjusted for age, centre, smoking, alcohol, and BMI. Bone turnover markers and heel broadband ultrasound attenuation (BUA) were measured in 3129 men aged 40-79. Two centres measured total hip, femoral neck, and lumbar spine areal bone mineral density (aBMD, n = 527) and performed radius peripheral quantitative computed tomography (pQCT, n = 595).
   Results MetS was present in 975 men (31.2 %). Men with MetS had lower beta C-terminal cross-linked telopeptide (beta-CTX), N-terminal propeptide of type I procollagen (PINP) and osteocalcin (P < 0.0001) and higher total hip, femoral neck, and lumbar spine aBMD (P = 0.03). Among MetS components, only hypertriglyceridaemia and hyperglycaemia were independently associated with PINP and beta-CTX. Hyperglycaemia was negatively associated with BUA, hypertriglyceridaemia with hip aBMD and radius cross-sectional area (CSA) and stress-strain index. HOMA-S was similarly associated with PINP and beta-CTX, BUA, and radius CSA in BMI-adjusted models.
   Conclusions Men with MetS have higher aBMD in association with their greater body mass, while their lower bone turnover and relative deficits in heel BUA and radius CSA are mainly related to correlates of insulin sensitivity. Our findings support the hypothesis that underlying metabolic complications may be involved in the bone's failure to adapt to increasing bodily loads in men with MetS.
C1 [Laurent, M. R.; Gielen, E.] Katholieke Univ Leuven, Dept Clin & Expt Med, Gerontol & Geriatr, Herestr 49,POB 7003, B-3000 Leuven, Belgium.
   [Laurent, M. R.; Antonio, L.] Katholieke Univ Leuven, Dept Cellular & Mol Med, Mol Endocrinol Lab, Herestr 49,POB 901, B-3000 Leuven, Belgium.
   [Laurent, M. R.; Gielen, E.] Univ Hosp Leuven, Ctr Metab Bone Dis, Herestr 49, B-3000 Leuven, Belgium.
   [Cook, M. J.; Pye, S. R.; O'Neill, T. W.] Univ Manchester, Manchester Acad Hlth Sci Ctr, Fac Med & Human Sci, Inst Inflammat & Repair,Arthrit Res UK Ctr Epidem, Stopford Bldg,Oxford Rd, Manchester M13 9PT, Lancs, England.
   [Ward, K. A.] Med Res Council Human Nutr Res, Elsie Widdowson Lab, 120 Fulbourn Rd, Cambridge CB1 9NL, England.
   [Antonio, L.; Decallonne, B.] Katholieke Univ Leuven, Dept Clin & Expt Med, Clin & Expt Endocrinol, Herestr 49,POB 902, B-3000 Leuven, Belgium.
   [Adams, J. E.] Cent Manchester Univ, Hosp NHS Fdn Trust, Dept Radiol, 46 Grafton St, Manchester M13 9NT, Lancs, England.
   [Adams, J. E.] Cent Manchester Univ, Hosp NHS Fdn Trust, Manchester Acad Hlth Sci Ctr, Manchester Royal Infirm, 46 Grafton St, Manchester M13 9NT, Lancs, England.
   [Adams, J. E.] Univ Manchester, 46 Grafton St, Manchester M13 9NT, Lancs, England.
   [Bartfai, G.] Albert Szent Gyorgyi Med Univ, Dept Obstet Gynecol & Androl, Semmelweis U 1, H-6725 Szeged, Hungary.
   [Casanueva, F. F.] Univ Santiago Compostela, Dept Med, Complejo Hosp Univ Santiago, CIBER Fisiopatol Obesidad & Nut,Inst Salud Carlos, Travesia Choupana S-N, Santiago De Compostela 15706, Spain.
   [Forti, G.] Univ Florence, Dept Clin Physiopathol, Androl Unit, Viale Pieraccini 6, I-50139 Florence, Italy.
   [Giwercman, A.] Lund Univ, Malmo Univ Hosp, Scanian Androl Ctr, Dept Urol, Jan Waldenstromsgata 35, S-20502 Malmo, Sweden.
   [Huhtaniemi, I. T.] Imperial Coll London, Dept Surg & Canc, Inst Reprod & Dev Biol, Hammersmith Campus, London W12 0HS, England.
   [Kula, K.] Med Univ Lodz, Dept Androl & Reprod Endocrinol, Pomorska 45-47, PL-90406 Lodz, Poland.
   [Lean, M. E. J.] Univ Glasgow, Glasgow Royal Infirm, Dept Human Nutr, Sch Med, Glasgow G31 2ER, Lanark, Scotland.
   [Lee, D. M.] Univ Manchester, Sch Social Sci, Cathie Marsh Inst Social Res, Humanities Bridgeford St G17, Manchester M13 9PL, Lancs, England.
   [Pendleton, N.] Univ Manchester, Sch Community Based Med, Salford Royal NHS Trust, Stott Lane, Salford M6 8HD, Lancs, England.
   [Punab, M.] Tartu Univ Clin, United Labs, Androl Unit, L Puusepa 1a, Tartu, Estonia.
   [Wu, F. C. W.] Univ Manchester, Manchester Royal Infirm, Manchester Acad Hlth Sci Ctr, Androl Res Unit,Dev & Regenerat Biomed Res, Grafton St, Manchester M13 9WL, Lancs, England.
   [O'Neill, T. W.] NIHR Manchester Musculoskeletal Biomed Res Unit, 29 Grafton St, Manchester M13 9WU, Lancs, England.
C3 KU Leuven; KU Leuven; KU Leuven; University Hospital Leuven; University
   of Manchester; University of Cambridge; UK Research & Innovation (UKRI);
   Medical Research Council UK (MRC); MRC Human Nutrition Research; KU
   Leuven; University of Manchester; University of Manchester; Szeged
   University; Universidade de Santiago de Compostela; Complexo
   Hospitalario Universitario de Santiago de Compostela; University of
   Florence; Lund University; Skane University Hospital; Imperial College
   London; Medical University Lodz; University of Glasgow; University of
   Manchester; University of Manchester; Salford Royal NHS Foundation
   Trust; University of Tartu; University of Manchester
RP Laurent, MR (corresponding author), Katholieke Univ Leuven, Dept Clin & Expt Med, Gerontol & Geriatr, Herestr 49,POB 7003, B-3000 Leuven, Belgium.; Laurent, MR (corresponding author), Katholieke Univ Leuven, Dept Cellular & Mol Med, Mol Endocrinol Lab, Herestr 49,POB 901, B-3000 Leuven, Belgium.; Laurent, MR (corresponding author), Univ Hosp Leuven, Ctr Metab Bone Dis, Herestr 49, B-3000 Leuven, Belgium.
EM michael.laurent@med.kuleuven.be
RI Kujala, Urho/AAP-2547-2020; Woo, Jean/K-2625-2014; Ward,
   Katherine/HKV-3840-2023; , Margus Punab/KXS-1159-2024; Laurent,
   Michael/D-5748-2011; Claessens, Frank/M-8565-2016; Pendleton,
   Neil/F-2333-2015; Antonio, Leen/T-1206-2018; Lee, David/D-1005-2009;
   Gielen, Evelien/L-6604-2018; Pye, Stephen/D-9236-2011
OI Laurent, Michael/0000-0001-9681-8330; Decallonne,
   Brigitte/0000-0003-4153-4757; Ward, Kate/0000-0001-7034-6750; Claessens,
   Frank/0000-0002-8676-7709; Pendleton, Neil/0000-0003-0794-2386; Cook,
   Michael/0000-0002-6551-9722; Antonio, Leen/0000-0002-1079-2860; Punab,
   Margus/0000-0001-9601-6311; Lee, David/0000-0003-3472-0789; Gielen,
   Evelien/0000-0002-8985-1201; vanderschueren, dirk/0000-0003-1395-0104;
   Pye, Stephen/0000-0002-7263-2897
FU Commission of the European Communities Fifth Framework Programme,
   Quality of Life and Management of Living Resources [QLK6-CT-2001-00258];
   Arthritis Research UK; Research Foundation Flanders [G.0171.03,
   G.0854.13N]; KU Leuven [GOA/15/017]; UK National Institute for Health
   Research Biomedical Research Unit Funding Scheme; UK Medical Research
   Council [U105960371]; University Hospitals Leuven, Belgium; MRC
   [MC_U105960371] Funding Source: UKRI
FX The European Male Ageing Study was funded by the Commission of the
   European Communities Fifth Framework Programme, Quality of Life and
   Management of Living Resources, Grant QLK6-CT-2001-00258, by Arthritis
   Research UK, by the Research Foundation Flanders grants G.0171.03 and
   G.0854.13N and KU Leuven grant GOA/15/017. This report includes
   independent research supported by the UK National Institute for Health
   Research Biomedical Research Unit Funding Scheme. The views expressed in
   this publication are those of the author(s) and not necessarily those of
   the NHS, the National Institute for Health Research or the Department of
   Health. The work of K.A.W. was conducted within the core programme of
   the MRC Nutrition and Bone Health Group at MRC Human Nutrition Research,
   funded by the UK Medical Research Council (Programme number U105960371).
   M.R.L. is a PhD Fellow of the Research Foundation Flanders. D.V. is a
   senior clinical investigator supported by the Clinical Research Fund of
   the University Hospitals Leuven, Belgium.
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NR 31
TC 28
Z9 31
U1 0
U2 4
PU SPRINGER LONDON LTD
PI LONDON
PA 236 GRAYS INN RD, 6TH FLOOR, LONDON WC1X 8HL, ENGLAND
SN 0937-941X
EI 1433-2965
J9 OSTEOPOROSIS INT
JI Osteoporosis Int.
PD NOV
PY 2016
VL 27
IS 11
BP 3227
EP 3237
DI 10.1007/s00198-016-3656-x
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA ED6GR
UT WOS:000388954600012
PM 27273111
DA 2025-06-11
ER

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   Seshadri, Sudha
   Boerwinkle, Eric
   Grove, Megan L.
   Larson, Nicholas B.
   Smith, Jennifer A.
   Vasan, Ramachandran S.
   Fitzpatrick, Annette L.
   Fornage, Myriam
   Ding, Jun
   Carson, April P.
   Abecasis, Goncalo
   Dupuis, Josee
   Reiner, Alexander
   Kooperberg, Charles
   Hou, Lifang
   Psaty, Bruce M.
   Wilson, James G.
   Levy, Daniel
   Rotter, Jerome I.
   Bis, Joshua C.
   Satizabal, Claudia L.
   Arking, Dan E.
   Liu, Chunyu
CA TOPMeD mtDNA Working Grp NHLBI Tra
TI Association Between Whole Blood-Derived Mitochondrial DNA Copy Number,
   Low-Density Lipoprotein Cholesterol, and Cardiovascular Disease Risk
SO JOURNAL OF THE AMERICAN HEART ASSOCIATION
LA English
DT Article
DE cardiometabolic risk factors; cardiovascular disease; low-density
   lipoprotein cholesterol; Mendelian randomization; mitochondrial DNA copy
   number; vascular atherosclerosis
ID MENDELIAN RANDOMIZATION; ATHEROSCLEROSIS RISK; OXIDATIVE STRESS;
   HEART-FAILURE; PERIPHERAL-BLOOD; DESIGN; HEALTH; COMMUNITIES;
   CLASSIFICATION; PLEIOTROPY
AB BACKGROUND: The relationship between mitochondrial DNA copy number (mtDNA CN) and cardiovascular disease remains elusive.
   METHODS AND RESULTS: We performed cross-sectional and prospective association analyses of blood-derived mtDNA CN and cardiovascular disease outcomes in 27 316 participants in 8 cohorts of multiple racial and ethnic groups with whole-genome sequencing. We also performed Mendelian randomization to explore causal relationships of mtDNA CN with coronary heart disease (CHD) and cardiometabolic risk factors (obesity, diabetes, hypertension, and hyperlipidemia). P<0.01 was used for significance. We validated most of the previously reported associations between mtDNA CN and cardiovascular disease outcomes. For example, 1-SD unit lower level of mtDNA CN was associated with 1.08 (95% CI, 1.04-1.12; P<0.001) times the hazard for developing incident CHD, adjusting for covariates. Mendelian randomization analyses showed no causal effect from a lower level of mtDNA CN to a higher CHD risk (beta=0.091; P=0.11) or in the reverse direction (beta=- 0.012; P=0.076). Additional bidirectional Mendelian randomization analyses revealed that low-density lipoprotein cholesterol had a causal effect on mtDNA CN (beta=-0.084; P<0.001), but the reverse direction was not significant (P=0.059). No causal associations were observed between mtDNA CN and obesity, diabetes, and hypertension, in either direction. Multivariable Mendelian randomization analyses showed no causal effect of CHD on mtDNA CN, controlling for low-density lipoprotein cholesterol level (P=0.52), whereas there was a strong direct causal effect of higher low-density lipoprotein cholesterol on lower mtDNA CN, adjusting for CHD status (beta=-0.092; P<0.001).
   CONCLUSIONS: Our findings indicate that high low-density lipoprotein cholesterol may underlie the complex relationships between mtDNA CN and vascular atherosclerosis.
C1 [Liu, Xue; Sun, Xianbang; Zhang, Yuankai; Jiang, Wenqing; Lai, Meng; Pitsillides, Achilleas; Dupuis, Josee; Liu, Chunyu] Boston Univ, Sch Publ Hlth, Dept Biostat, 801 Massachusetts Ave,Third Floor, Boston, MA 02118 USA.
   [Wiggins, Kerri L.; Psaty, Bruce M.; Bis, Joshua C.] Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA USA.
   [Raffield, Laura M.] Univ N Carolina, Dept Genet, Chapel Hill, NC USA.
   [Bielak, Lawrence F.; Zhao, Wei; Peyser, Patricia A.; Smith, Jennifer A.] Univ Michigan, Dept Epidemiol, Sch Publ Hlth, Ann Arbor, MI USA.
   [Zhao, Wei; Smith, Jennifer A.] Univ Michigan, Survey Res Ctr, Inst Social Res, Ann Arbor, MI USA.
   [Haessler, Jeffrey; Reiner, Alexander; Kooperberg, Charles] Fred Hutchinson Canc Ctr, Div Publ Hlth Sci, Seattle, WA USA.
   [Zheng, Yinan; Hou, Lifang] Northwestern Univ, Feinberg Sch Med, Chicago, IL USA.
   [Blackwell, Thomas W.; Abecasis, Goncalo] Univ Michigan, TOPMed Informat Res Ctr, Ann Arbor, MI USA.
   [Yao, Jie; Guo, Xiuqing; Taylor, Kent D.; Rotter, Jerome I.] Harbor UCLA Med Ctr, Inst Translat Genom & Populat Sci, Dept Pediat, Lundquist Inst Biomed Innovat, Torrance, CA USA.
   [Qian, Yong; Ding, Jun] NIA, Longitudinal Studies Sect, Translat Gerontol Branch, NIH, Baltimore, MD USA.
   [Thyagarajan, Bharat] Univ Minnesota, Dept Lab Med & Pathol, Minneapolis, MN USA.
   [Pankratz, Nathan] Univ Minnesota, Dept Computat Pathol, Minneapolis, MN USA.
   [Rich, Stephen S.] Univ Virginia, Ctr Publ Hlth Genom, Charlottesville, VA USA.
   [Heckbert, Susan R.] Univ Washington, Cardiovasc Hlth Res Unit, Seattle, WA USA.
   [Heckbert, Susan R.] Univ Washington, Dept Epidemiol, Seattle, WA USA.
   [Seshadri, Sudha; Satizabal, Claudia L.] Univ Texas Hlth Sci Ctr San Antonio, Glenn Biggs Inst Alzheimers & Neurodegenerat Dis, San Antonio, TX USA.
   [Seshadri, Sudha; Vasan, Ramachandran S.; Levy, Daniel; Satizabal, Claudia L.; Liu, Chunyu] NHLBI, Framingham Heart Study, Framingham, MA USA.
   [Seshadri, Sudha; Satizabal, Claudia L.] Boston Univ, Dept Neurol, Sch Med, Boston, MA USA.
   [Boerwinkle, Eric; Grove, Megan L.] Univ Texas Hlth Sci Ctr Houston, Ctr Human Genet, Dept Epidemiol Human Genet & Environm Sci, Houston, TX USA.
   [Boerwinkle, Eric] Baylor Coll Med, Human Genome Sequencing Ctr, Houston, TX USA.
   [Larson, Nicholas B.] Mayo Clin, Div Clin Trials & Biostat, Dept Quantitat Hlth Sci, Coll Med & Sci, Rochester, MN USA.
   [Vasan, Ramachandran S.] Boston Univ, Sch Med, Sect Prevent Med & Epidemiol, Boston, MA USA.
   [Vasan, Ramachandran S.] Boston Univ, Sch Med, Sect Cardiovasc Med, Boston, MA USA.
   [Fitzpatrick, Annette L.] Univ Washington, Dept Family Med, Seattle, WA USA.
   [Fitzpatrick, Annette L.; Psaty, Bruce M.] Univ Washington, Dept Epidemiol, Seattle, WA USA.
   [Fitzpatrick, Annette L.] Univ Washington, Dept Global Hlth, Seattle, WA USA.
   [Fornage, Myriam] Univ Texas Hlth Sci Ctr Houston, Ctr Human Genet, Houston, TX USA.
   [Carson, April P.] Univ Mississippi, Dept Med, Med Ctr, Jackson, MS USA.
   [Dupuis, Josee] McGill Univ, Fac Med & Hlth Sci, Dept Epidemiol Biostat & Occupat Hlth, Sch Populat & Global Hlth, Montreal, PQ, Canada.
   [Psaty, Bruce M.] Univ Washington, Dept Hlth Syst & Populat Hlth, Seattle, WA USA.
   [Wilson, James G.] Beth Israel Deaconess Med Ctr, Div Cardiovasc Med, Boston, MA USA.
   [Levy, Daniel] NHLBI, Populat Sci Branch, NIH, Bethesda, MD USA.
   [Arking, Dan E.] Johns Hopkins Univ, McKusick Nathans Inst, Dept Med Genet, Sch Med, Baltimore, MD USA.
C3 Boston University; University of Washington; University of Washington
   Seattle; University of North Carolina; University of North Carolina
   Chapel Hill; University of Michigan System; University of Michigan;
   University of Michigan System; University of Michigan; Fred Hutchinson
   Cancer Center; Northwestern University; Feinberg School of Medicine;
   University of Michigan System; University of Michigan; University of
   California System; University of California Los Angeles; University of
   California Los Angeles Medical Center; National Institutes of Health
   (NIH) - USA; NIH National Institute on Aging (NIA); University of
   Minnesota System; University of Minnesota Twin Cities; University of
   Minnesota System; University of Minnesota Twin Cities; University of
   Virginia; University of Washington; University of Washington Seattle;
   University of Washington; University of Washington Seattle; University
   of Texas System; University of Texas Health Science Center at San
   Antonio; National Institutes of Health (NIH) - USA; NIH National Heart
   Lung & Blood Institute (NHLBI); Framingham Heart Study; Boston
   University; University of Texas System; University of Texas Health
   Science Center Houston; Baylor College of Medicine; Mayo Clinic; Boston
   University; Boston University; University of Washington; University of
   Washington Seattle; University of Washington; University of Washington
   Seattle; University of Washington; University of Washington Seattle;
   University of Texas System; University of Texas Health Science Center
   Houston; University of Mississippi; University of Mississippi Medical
   Center; McGill University; University of Washington; University of
   Washington Seattle; Harvard University; Harvard University Medical
   Affiliates; Beth Israel Deaconess Medical Center; National Institutes of
   Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI);
   Johns Hopkins University
RP Liu, CY (corresponding author), Boston Univ, Sch Publ Hlth, Dept Biostat, 801 Massachusetts Ave,Third Floor, Boston, MA 02118 USA.
EM liuc@bu.edu
RI Larson, Nicholas/AEY-9578-2022; Zhang, Yuankai/GZK-8680-2022; Smith,
   Albert Vernon/AHC-3838-2022; Reiner-Benaim, Anat/HGQ-1183-2022;
   Ramachandran, Vasan/Y-2527-2019; Rotter, Jerome/AAY-6598-2021; jiang,
   wenqing/AAW-3649-2021; Liu, chunyu/Q-3901-2017; Boerwinkle,
   Eric/B-9599-2015; Zheng, Yinan/E-5775-2017; Levy, Daniel/ABB-2752-2021;
   Ford, James/A-4284-2013; Deng, Jun/X-6902-2019
OI Raffield, Laura/0000-0002-7892-193X; Wiggins, Kerri
   L/0000-0003-2749-1279; Hou, Lifang/0000-0003-4877-0031; Zhao,
   Wei/0000-0001-7388-0692; Smith, Jennifer Ann/0000-0002-3575-5468;
   Bielak, Lawrence/0000-0002-3443-8030; Pitsillides,
   Achilleas/0000-0002-2658-1566; Liu, Xue/0000-0002-4196-3597
FU National Heart, Lung, and Blood Institute (NHLBI); TOPMed Informatics
   Research Center [HHSN268201800002I]; TOPMed Data Coordinating Center
   [HHSN268201800002I, HHSN268201800001I]; NHLBI, National Institutes of
   Health, and Department of Health and Human Services [75N92022D00001,
   75N92022D00002, 75N92022D00003, 75N92022D00004, 75N92022D00005]; NHLBI;
   University of Alabama at Birmingham [HHSN268201800005I,
   HHSN268201800007I]; Northwestern University [HHSN268201800003I];
   University of Minnesota [HHSN268201800006I]; Kaiser Foundation Research
   Institute [HHSN268201800004I]; NHLBI [HHSN268201200036C,
   HHSN268200800007C, HHSN268201800001C, N01HC55222, N01HC85079,
   N01HC85080, N01HC85081, N01HC85082, N01HC85083, N01HC85086,
   75N92021D00006, U01HL080295, U01HL130114, R01HL105756,
   HHSN268201600033I, 3U54HG003273-12S2, HHSN268201500015C, NO1-HC25195,
   HHSN268201500001I, 75N92019D00031, HHSN268201800013I, HHSN268201800014I,
   HHSN268201800015I, HHSN268201800010I, HHSN268201800011I,
   HHSN268201800012I]; National Institute on Aging (NIA) [R01AG023629];
   National Institute of Neurological Disorders and Stroke (NINDS); Evans
   Medical Foundation; Jay and Louis Coffman Endowment from the Department
   of Medicine, Boston University School of Medicine; NIA/NIH [AG052409,
   AG054076, AG059421]; NHLBI of the National Institutes of Health
   [HL054457, HL054464, HL054481, HL141292, HL119443, HL087660]; National
   Institute on Minority Health and Health Disparities (NIMHD); National
   Center for Advancing Translational Sciences, National Institutes of
   Health [KL2TR002490]; The NHLBI [75N92020D00001, HHSN268201500003I,
   N01-HC-95159, 75N92020D00005, N01-HC-95160, 75N92020D00002,
   N01-HC-95161, 75N92020D00003, N01-HC-95162, 75N92020D00006,
   N01-HC-95163, 75N92020D00004, N01-HC-95164, 75N92020D00007,
   N01-HC-95165]; NHLBI, National Institutes of Health, US Department of
   Health and Human Services [75N92021D00001, 75N92021D00002,
   75N92021D00003, 75N92021D00004, 75N92021D00005]; 'NHLBI' [R01HL105756,
   N01-HC-95166, N01-HC-95167, N01-HC95168, N01-HC-95169, UL1-TR-000040,
   UL1-TR-001079, UL1-TR001420, UL1TR001881, DK063491];  [R01
   HL092577-06S1];  [R01AG059727]
FX Whole-genome sequencing (WGS) for the Trans-Omics in Precision Medicine
   (TOPMed) program was supported by the National Heart, Lung, and Blood
   Institute (NHLBI). Centralized read mapping and genotype calling, along
   with variant quality metrics and filtering, were provided by the TOPMed
   Informatics Research Center (R01HL-117 626-02S1; contract
   HHSN268201800002I). Phenotype harmonization, data management,
   sample-identity quality control, and general study coordination were
   provided by the TOPMed Data Coordinating Center (R01HL-120 393-02S1;
   contract HHSN268201800001I). Additional phenotype harmonization was
   performed by the current study (NIA/NIH; R01AG059727). Funding resources
   for all participating institutes are described below. The ARIC
   (Atherosclerosis Risk in Communities) study has been funded in whole or
   in part with federal funds from the NHLBI, National Institutes of
   Health, and Department of Health and Human Services, under contracts
   75N92022D00001, 75N92022D00002, 75N92022D00003, 75N92022D00004, and
   75N92022D00005. The authors thank the staff and participants of the ARIC
   study for their important contributions. WGS for "NHLBI TOPMed:
   Atherosclerosis Risk in Communities" (phs001211.v3.p2.c1) was performed
   at the Baylor College of Medicine Human Genome Sequencing Center
   (3U54HG003273-12S2/HHSN268201500015C). Core support, including
   centralized genomic read mapping and genotype calling, along with
   variant quality metrics and filtering were provided by the TOPMed
   Informatics Research Center (3R01HL-117 626-02S1; contract
   HHSN268201800002I). Core support, including phenotype harmonization,
   data management, sample-identity quality control, and general program
   coordination were provided by the TOPMed Data Coordinating Center
   (R01HL-120393; U01HL-120393; contract HHSN268201800001I). The ARIC study
   gratefully acknowledges the study participants who provided biological
   samples and data for TOPMed. The CARDIA (Coronary Artery Risk
   Development in Young Adults) study is conducted and supported by the
   NHLBI in collaboration with the University of Alabama at Birmingham
   (HHSN268201800005I and HHSN268201800007I), Northwestern University
   (HHSN268201800003I), University of Minnesota (HHSN268201800006I), and
   Kaiser Foundation Research Institute (HHSN268201800004I). WGS in CARDIA
   (phs001612) was performed at the Baylor Human Genome Sequencing Center
   (HHSN268201600033I). Centralized read mapping and genotype calling,
   along with variant quality metrics and filtering, were provided by the
   TOPMed Informatics Research Center (3R01HL-117 626-02S1). Phenotype
   harmonization, data management, sample-identity quality control, and
   general study coordination were provided by the TOPMed Data Coordinating
   Center (3R01HL-120 393-02S1). The CARDIA study gratefully acknowledges
   the study participants who provided biological samples and data for
   TOPMed. We also thank the staff of the CARDIA study. The CHS
   (Cardiovascular Health Study) is supported by contracts
   HHSN268201200036C, HHSN268200800007C, HHSN268201800001C, N01HC55222,
   N01HC85079, N01HC85080, N01HC85081, N01HC85082, N01HC85083, N01HC85086,
   and 75N92021D00006 and grants U01HL080295, U01HL130114, and R01HL105756
   from the NHLBI, with additional contribution from the National Institute
   of Neurological Disorders and Stroke (NINDS). Additional support was
   provided by R01AG023629 from the National Institute on Aging (NIA). A
   full list of principal CHS investigators and institutions can be found
   at CHS-NHLBI. org. The content is solely the responsibility of the
   authors and does not necessarily represent the official views of the
   National Institutes of Health. Sequencing was supported and conducted in
   collaboration with Baylor University (HHSN268201600033I,
   3U54HG003273-12S2, and HHSN268201500015C) and Broad Genomics
   (HHSN268201600034I) contracts from NHLBI. The WGS for FHS (Framingham
   Heart Study) (phs000974) was performed at the Broad Institute of MIT and
   Harvard (3R01HL092577-06S1 and 3U54HG003067-12S2). The FHS is funded by
   contracts NO1-HC25195, HHSN268201500001I, and 75N92019D00031 from the
   NHLBI and grant supplement R01 HL092577-06S1 for this research. The FHS
   also acknowledges the dedication of the FHS participants without whom
   this research would not be possible. Dr Vasan is supported in part by
   the Evans Medical Foundation and the Jay and Louis Coffman Endowment
   from the Department of Medicine, Boston University School of Medicine.
   Xue Liu, Sudha Seshadri, Claudia L. Satizabal, and Chunyu Liu are also
   supported by R01AG059727. Sudha Seshadri, Claudia L. Satizabal are also
   supported by NIA/NIH (AG052409, AG054076, and AG059421). The GENOA
   (Genetic Epidemiology Network of Arteriopathy) study is supported by the
   NHLBI (HL054457, HL054464, HL054481, HL141292, HL119443, and HL087660)
   of the National Institutes of Health. Sequencing for the GENOA
   (phs001345. v1.p1) was performed by the University of Washington
   Northwest Genomics Center (3R01HL055673-18S1 from the NHLBI and at the
   Broad Institute of MIT and Harvard [HHSN268201500014C]). The authors
   thank the staff and participants of GENOA. The JHS (Jackson Heart Study)
   is supported and conducted in collaboration with Jackson State
   University (HHSN268201800013I), Tougaloo College (HHSN268201800014I),
   the Mississippi State Department of Health (HHSN268201800015I), and the
   University of Mississippi Medical Center (HHSN268201800010I,
   HHSN268201800011I, and HHSN268201800012I) contracts from the NHLBI and
   the National Institute on Minority Health and Health Disparities
   (NIMHD). The authors thank the staff and participants of the JHS.
   Molecular data for the TOPMed program were supported by the NHLBI.
   Genome sequencing for "NHLBI TOPMed: The Jackson Heart Study"
   (phs000964.v1.p1) was performed at the Northwest Genomics Center
   (HHSN268201100037C). Core support, including centralized genomic read
   mapping and genotype calling, along with variant quality metrics and
   filtering, was provided by the TOPMed Informatics Research Center
   (3R01HL-117 626-02S1; contract HHSN268201800002I). Core support,
   including phenotype harmonization, data management, sample-identity
   quality control, and general program coordination, was provided by the
   TOPMed Data Coordinating Center (R01HL-120 393 and U01HL-120 393;
   contract HHSN268201800001I). Laura Raffield was also supported by the
   National Center for Advancing Translational Sciences, National
   Institutes of Health, through grant KL2TR002490. The JHS gratefully
   acknowledges the studies and participants who provided biological
   samples and data for TOPMed. The MESA (Multi-Ethnic Study of
   Atherosclerosis) is conducted and supported by the NHLBI in
   collaboration with MESA investigators. MESA projects are conducted and
   supported by the NHLBI in collaboration with MESA investigators. Support
   for MESA is provided by contracts 75N92020D00001, HHSN268201500003I,
   N01-HC-95159, 75N92020D00005, N01-HC-95160, 75N92020D00002,
   N01-HC-95161, 75N92020D00003, N01-HC-95162, 75N92020D00006,
   N01-HC-95163, 75N92020D00004, N01-HC-95164, 75N92020D00007,
   N01-HC-95165, N01-HC-95166, N01-HC-95167, N01-HC95168, N01-HC-95169,
   UL1-TR-000040, UL1-TR-001079, UL1-TR001420, UL1TR001881, DK063491, and
   R01HL105756. WGS for the TOPMed program was supported by the NHLBI. WGS
   for "NHLBI TOPMed: Multi-Ethnic Study of Atherosclerosis (MESA)"
   (phs001416.v1.p1) was performed at the Broad Institute of MIT and
   Harvard (3U54HG003067-13S1). Centralized read mapping and genotype
   calling, along with variant quality metrics and filtering, were provided
   by the TOPMed Informatics Research Center (3R01HL-117 626-02S1).
   Phenotype harmonization, data management, sample-identity quality
   control, and general study coordination, were provided by the TOPMed
   Data Coordinating Center (3R01HL-120 393-02S1) and TOPMed MESA
   Multi-Omics (HHSN2682015000031/HSN26800004). The authors thank the other
   investigators, the staff, and the participants of the MESA for their
   valuable contributions. A full list of participating MESA investigators
   and institutes can be found at http://www.mesa-nhlbi.org.The WHI
   (Women's Health Initiative) study program is funded by the NHLBI,
   National Institutes of Health, US Department of Health and Human
   Services through contracts 75N92021D00001, 75N92021D00002,
   75N92021D00003, 75N92021D00004, and 75N92021D00005. The WHI study thanks
   all WHI study participants for their dedication and contributions. The
   views expressed in this article are those of the authors and do not
   necessarily represent the views of the NHLBI, the National Institutes of
   Health, or the US Department of Health and Human Services.
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NR 72
TC 10
Z9 10
U1 1
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
EI 2047-9980
J9 J AM HEART ASSOC
JI J. Am. Heart Assoc.
PD OCT 17
PY 2023
VL 12
IS 20
AR e029090
DI 10.1161/JAHA.122.029090
PG 13
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA W1ZG5
UT WOS:001089678400035
PM 37804200
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU McIntyre, RS
   Cha, DS
   Jerrell, JM
   Soczynska, JK
   Woldeyohannes, HO
   Taylor, V
   Kaidanovich-Beilin, O
   Alsuwaidan, M
   Ahmed, AT
AF McIntyre, Roger S.
   Cha, Danielle S.
   Jerrell, Jeanette M.
   Soczynska, Joanna K.
   Woldeyohannes, Hanna O.
   Taylor, Valerie
   Kaidanovich-Beilin, Oksana
   Alsuwaidan, Mohammad
   Ahmed, Ameena T.
TI Obesity and Mental Illness: Implications for Cognitive Functioning
SO ADVANCES IN THERAPY
LA English
DT Review
DE Cognition; Dementia; Mental illness; Mood disorder; Neuropsychiatric
   disorders; Obesity; Psychiatry
ID ANXIETY TREATMENTS CANMAT; TASK-FORCE RECOMMENDATIONS; BODY-MASS INDEX;
   BIPOLAR DISORDER; DEFAULT-MODE; CANADIAN NETWORK; MOOD DISORDERS;
   METABOLIC SYNDROME; ALZHEIMERS-DISEASE; PREFRONTAL CORTEX
AB A priority research and clinical agenda is to identify determinants of cognitive impairment in individuals with neuropsychiatric disorders (NPD). The bidirectional association between NPD and cognitive performance has been reported to be mediated and/or moderated by obesity in a subset of individuals. Obesity can be conceptualized as a neurotoxic phenotype among individuals with NPD as evidenced by alterations in the structure and function of neural circuits and disseminated networks, diminished cognitive performance, and adverse effects on illness trajectory. The neurotoxic effect of obesity provides a rationale for screening, treating, and preventing obesity in neuropsychiatric populations. Research endeavors that aim to refine mediators and moderators of this association as well as novel strategies to reverse the injurious process of obesity on cognition are warranted.
C1 [McIntyre, Roger S.; Alsuwaidan, Mohammad] Univ Toronto, Dept Psychiat, Toronto, ON, Canada.
   [McIntyre, Roger S.] Univ Toronto, Dept Pharmacol, Toronto, ON, Canada.
   [McIntyre, Roger S.; Cha, Danielle S.; Soczynska, Joanna K.] Univ Toronto, Inst Med Sci, Toronto, ON, Canada.
   [McIntyre, Roger S.; Cha, Danielle S.; Soczynska, Joanna K.; Woldeyohannes, Hanna O.; Kaidanovich-Beilin, Oksana; Alsuwaidan, Mohammad] Univ Hlth Network, Mood Disorders Psychopharmacol Unit, Toronto, ON M5T 2S8, Canada.
   [Jerrell, Jeanette M.] Univ S Carolina, Sch Med, Dept Neuropsychiat, Columbia, SC USA.
   [Taylor, Valerie] Univ Toronto, Toronto, ON, Canada.
   [Kaidanovich-Beilin, Oksana] Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Toronto, ON M5G 1X5, Canada.
   [Ahmed, Ameena T.] Permanente Med Grp Inc, San Francisco, CA 94115 USA.
   [Ahmed, Ameena T.] Kaiser Permanente Div Res, San Francisco, CA 94115 USA.
C3 University of Toronto; University of Toronto; University of Toronto;
   University of Toronto; University Health Network Toronto; University of
   South Carolina System; University of South Carolina Columbia; University
   of Toronto; University of Toronto; Sinai Health System Toronto;
   Lunenfeld Tanenbaum Research Institute; Permanente Medical Groups;
   Kaiser Permanente
RP McIntyre, RS (corresponding author), Univ Hlth Network, Mood Disorders Psychopharmacol Unit, 399 Bathurst St, Toronto, ON M5T 2S8, Canada.
EM Roger.McIntyre@uhn.ca
RI McIntyre, Roger/AAU-1000-2020; Taylor, Valerie/H-6242-2015
OI Taylor, Valerie/0000-0002-8948-638X; Alsuwaidan,
   Mohammad/0000-0003-1344-2935; Soczynska, Joanna/0000-0003-0003-7164
FU Stanley Medical Research Institute; National Alliance for Research on
   Schizophrenia and Depression (NARSAD); National Institutes of Mental
   Health; Astra Zeneca; Eli Lilly; Jannsen-Ortho; Lundbeck; Pfizer; Shire;
   Elan; Sunovion; CANMAT; Servier
FX RS McIntyre has received research grants from Stanley Medical Research
   Institute, National Alliance for Research on Schizophrenia and
   Depression (NARSAD), National Institutes of Mental Health, Astra Zeneca,
   Eli Lilly, Jannsen-Ortho, Lundbeck, Pfizer, and Shire; has served on
   advisory boards for Astra Zeneca, Bristol-Myers Squibb, Eli Lilly,
   France Foundation, GlaxoSmithKline, Janssen-Ortho, Lundbeck, Merck,
   Organon, Pfizer, and Shire; has served on speakers bureaus for Astra
   Zeneca, Eli Lilly, Janssen-Ortho, Lundbeck, Merck, Pfizer; and CME
   activities for Astra Zeneca, Bristol-Myers Squibb, CME Outfitters, Eli
   Lilly, France Foundation, I3CME, Merck, Optum Health, Pfizer,
   Physicians' Postgraduate Press. M. Alsuwaidan has received
   research/clinical trials grants from Elan, Lundbeck, Shire, and
   Sunovion; honoraria from Astra Zeneca and CANMAT; and travel funds from
   CANMAT and Servier. D. Cha declares no conflict of interest. J. Jerrell
   declares no conflict of interest. J. Soczynska declares no conflict of
   interest. H. Woldeyohannes declares no conflict of interest. V. Taylor
   declares no conflict of interest. O. Kaidanovich-Beilin declares no
   conflict of interest. A. Ahmed declares no conflict of interest.
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NR 99
TC 13
Z9 14
U1 2
U2 23
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0741-238X
EI 1865-8652
J9 ADV THER
JI Adv. Ther.
PD JUN
PY 2013
VL 30
IS 6
BP 577
EP 588
DI 10.1007/s12325-013-0040-5
PG 12
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA 180HY
UT WOS:000321586000002
PM 23839214
DA 2025-06-11
ER

PT J
AU de la Iglesia, R
   Lopez-Legarrea, P
   Abete, I
   Bondia-Pons, I
   Navas-Carretero, S
   Forga, L
   Martinez, JA
   Zulet, MA
AF de la Iglesia, Rocio
   Lopez-Legarrea, Patricia
   Abete, Itziar
   Bondia-Pons, Isabel
   Navas-Carretero, Santiago
   Forga, Luis
   Alfredo Martinez, J.
   Angeles Zulet, M.
TI A new dietary strategy for long-term treatment of the metabolic syndrome
   is compared with the American Heart Association ( AHA) guidelines: the
   MEtabolic Syndrome REduction in NAvarra ( RESMENA) project
SO BRITISH JOURNAL OF NUTRITION
LA English
DT Article
DE Obesity; Energy restriction; Fibre; Macronutrient distribution
ID SERUM URIC-ACID; TOTAL ANTIOXIDANT CAPACITY; TYPE-2 DIABETES-MELLITUS;
   WEIGHT-LOSS; BODY-WEIGHT; CARDIOVASCULAR-DISEASE; OXIDATIVE STRESS;
   HEALTH-BENEFITS; GLYCEMIC INDEX; LIVER-ENZYMES
AB The long-term effects of dietary strategies designed to combat the metabolic syndrome (MetS) remain unknown. The present study evaluated the effectiveness of a new dietary strategy based on macronutrient distribution, antioxidant capacity and meal frequency (MEtabolic Syndrome REduction in NAvarra (RESMENA) diet) for the treatment of the MetS when compared with the American Heart Association guidelines, used as Control. Subjects with the MetS (fifty-two men and forty-one women, age 49 (se 1) years, BMI 36.11 (se 0.5) kg/m(2)) were randomly assigned to one of two dietary groups. After a 2-month nutritional-learning intervention period, during which a nutritional assessment was made for the participants every 15d, a 4-month self-control period began. No significant differences were found between the groups concerning anthropometry, but only the RESMENA group exhibited a significant decrease in body weight (-1.7%; P=0.018), BMI (-1.7%; P=0.019), waist circumference (-1.8%; P=0.021), waist:hip ratio (-1.4%; P=0.035) and android fat mass (-6.9%; P=0.008). The RESMENA group exhibited a significant decrease in alanine aminotransferase and aspartate aminotransferase (AST) concentrations (-26.8%; P=0.008 and -14.0%; P=0.018, respectively), while the Control group exhibited a significant increase in glucose (7.9%; P=0.011), AST (11.3%; P=0.045) and uric acid (9.0%; P<0.001) concentrations. LDL-cholesterol (LDL-C) concentrations were increased (Control group: 34.4%; P<0.001 and RESMENA group: 33.8%; P<0.001), but interestingly so were the LDL-C:apoB ratio (Control group: 28.7%; P<0.001, RESMENA group: 17.1%; P=0.009) and HDL-cholesterol concentrations (Control group: 21.1%; P<0.001, RESMENA group: 8.7; P=0.001). Fibre was the dietary component that most contributed to the improvement of anthropometry, while body-weight loss explained changes in some biochemical markers. In conclusion, the RESMENA diet is a good long-term dietary treatment for the MetS.
C1 [de la Iglesia, Rocio; Lopez-Legarrea, Patricia; Bondia-Pons, Isabel; Navas-Carretero, Santiago; Alfredo Martinez, J.; Angeles Zulet, M.] Univ Navarra, Dept Nutr Food Sci & Physiol, E-31080 Pamplona, Spain.
   [Abete, Itziar] BioDonostia Hlth Res Inst, Dept Neurosci, San Sebastian, Spain.
   [Navas-Carretero, Santiago; Alfredo Martinez, J.; Angeles Zulet, M.] CIBERobn Centro Investigac Biomed Red Fisiopatol, Madrid, Spain.
   [Forga, Luis] Hosp Complex Navarra, Pamplona, Spain.
C3 University of Navarra; Instituto de Investigacion Sanitaria Biogipuzkoa;
   CIBER - Centro de Investigacion Biomedica en Red; CIBEROBN; Servicio
   Navarro de Salud - Osasunbidea
RP Martinez, JA (corresponding author), Univ Navarra, Dept Nutr Food Sci & Physiol, E-31080 Pamplona, Spain.
EM jalfmtz@unav.es
RI de la Iglesia, Rocio/ABC-6189-2020; Abete, Itziar/H-4827-2017; Zulet, M.
   Angeles/H-1317-2017; Martinez Hernandez, J Alfredo/K-8709-2014;
   Navas-Carretero, Santiago/L-2918-2015
OI Abete, Itziar/0000-0002-6475-5387; Zulet, M.
   Angeles/0000-0002-3926-0892; Martinez Hernandez, J
   Alfredo/0000-0001-5218-6941; de la Iglesia, Rocio/0000-0002-7472-3565;
   Navas-Carretero, Santiago/0000-0002-5163-2230
FU Health Department of the Government of Navarra [48/2009]; Linea Especial
   about Nutrition, Obesity and Health (University of Navarra) [LE/97];
   CIBERobn scheme; RETICS scheme; Carlos III Health Institute [FI10/00587]
FX The present study was supported by the Health Department of the
   Government of Navarra (48/2009) and the Linea Especial about Nutrition,
   Obesity and Health (University of Navarra LE/97). The support from
   CIBERobn and RETICS schemes is gratefully acknowledged. Carlos III
   Health Institute provided a predoctoral grant to R.I (no. FI10/00587).
   None of the funding institutions and frameworks had a role in the design
   and analysis of the study or in writing of the article.
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NR 69
TC 71
Z9 75
U1 0
U2 13
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1145
EI 1475-2662
J9 BRIT J NUTR
JI Br. J. Nutr.
PD FEB 28
PY 2014
VL 111
IS 4
BP 643
EP 652
DI 10.1017/S0007114513002778
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA AD0SE
UT WOS:000332943600009
PM 23968597
OA Green Submitted, Bronze
DA 2025-06-11
ER

PT J
AU Abplanalp, SJ
   Fulford, D
AF Abplanalp, Samuel J.
   Fulford, Daniel
TI Physical effort exertion and pain: Links with trait-based risk for
   psychopathology
SO PSYCHIATRY RESEARCH
LA English
DT Article
DE Serious mental illness; Schizotypy; Hypomania; Anhedonic depression;
   Clinical pain; Physical activity
ID MAJOR DEPRESSIVE DISORDER; SEVERE MENTAL-ILLNESS; BIPOLAR DISORDER;
   METABOLIC SYNDROME; TRIPARTITE MODEL; PEOPLE; SCHIZOPHRENIA; SCALE;
   METAANALYSIS; PERCEPTION
AB People with serious mental illness (SMI) are at an increased risk for physical health complications, such as cardiovascular disease and obesity. Low levels of physical activity is a major contributor to these health complications. One factor associated with limited physical activity in the broader sedentary population is pain. While preliminary findings suggest an association between lack of physical activity and pain in SMI, conclusions are still unclear. Thus, the goal of this correlational study was to examine associations between trait-based risk for psychopathology (hypomanic personality, schizotypy, and anhedonic depression) and the experience of pain following a physical endurance/effort task. Healthy participants (N = 43; 18 females) completed self-report measures of trait-based risk for psychopathology. They also reported on the experience of pain before and after the Time To Exhaustion (TTE) test. Findings revealed that risk for psychosis and anhedonic depression were associated with increases in pain following the TTE test, accounting for other key variables, such as age and self reported physical exercise. Risk for mania was unrelated to changes in pain. These results suggest that the experience of pain in relation to physical endurance/effort may contribute to diminished physical activity among people at risk for SMI.
C1 [Abplanalp, Samuel J.; Fulford, Daniel] Boston Univ, Sargent Coll, Coll Hlth & Rehabil Sci, Boston, MA 02215 USA.
   [Fulford, Daniel] Boston Univ, Dept Psychol & Brain Sci, Boston, MA 02215 USA.
C3 Boston University; Boston University
RP Abplanalp, SJ (corresponding author), Boston Univ, Sargent Coll, Coll Hlth & Rehabil Sci, Boston, MA 02215 USA.
EM samabp@bu.edu
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NR 61
TC 4
Z9 4
U1 1
U2 4
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0165-1781
J9 PSYCHIAT RES
JI Psychiatry Res.
PD JAN
PY 2019
VL 271
BP 46
EP 51
DI 10.1016/j.psychres.2018.10.010
PG 6
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA HO1YZ
UT WOS:000460709900008
PM 30465981
DA 2025-06-11
ER

PT J
AU Shakil, SS
   Temu, TM
   Kityo, C
   Erem, G
   Bittencourt, MS
   Longenecker, CT
AF Shakil, Saate S.
   Temu, Tecla M.
   Kityo, Cissy
   Erem, Geoffrey
   Bittencourt, Marcio S.
   Longenecker, Chris T.
TI Circulating plasma NT-proBNP predicts subclinical coronary
   atherosclerosis on CT angiography among older adults in Uganda
SO BMC RESEARCH NOTES
LA English
DT Article
DE Cardiovascular disease; Coronary artery disease; Biomarkers; Myocardial
   stress
ID NATRIURETIC PEPTIDE
AB ObjectivePhenotypes and mechanisms of cardiovascular disease (CVD) may differ across global populations. In sub-Saharan Africa (SSA), distinct environmental determinants may influence development and progression of atherosclerotic coronary artery disease (CAD).MethodsWe investigated associations between 6 established markers of myocardial stress and subsequent subclinical CAD (sCAD), defined as presence of any atherosclerosis on coronary CT angiography (CCTA) in a 2-year prospective cohort of Ugandan adults enriched for cardiometabolic risk factors (RFs) and HIV. Six plasma biomarkers were measured baseline among 200 participants (50% with HIV) aged >= 45 years with >= 1 cardiovascular RF. At 2-year follow-up, 132 participants (52% with HIV) who returned underwent coronary CCTA.ResultsIn logistic regression models adjusted for cardiovascular RFs (age, diabetes, hypertension, hyperlipidemia, smoking, obesity) and non-traditional RFs (HIV, chronic kidney disease), only NT-proBNP predicted subsequent subclinical CAD (p < 0.008, Bonferroni correction for multiple testing). In sensitivity analyses adjusted for ASCVD risk category (instead of individual RFs) in the baseline cohort with multiple imputation applied to missing year 2 CCTA data (n = 200), NT-proBNP remained significantly associated with subsequent CAD (p < 0.008).ConclusionsNT-proBNP consistently predicted subclinical CAD in Uganda in the absence of such an association among other markers of myocardial stress, suggesting a role for NT-proBNP in atherosclerosis independently of coronary microvascular dysfunction.
C1 [Shakil, Saate S.] Univ Calif San Francisco, Dept Med, Div Cardiol, San Francisco, CA 94118 USA.
   [Temu, Tecla M.; Longenecker, Chris T.] Univ Washington, Dept Global Hlth, Med Ctr, Seattle, WA USA.
   [Kityo, Cissy] Joint Clin Res Ctr, Kampala, Uganda.
   [Erem, Geoffrey] Makerere Univ, Dept Radiol, Kampala, Uganda.
   [Bittencourt, Marcio S.] Univ Pittsburgh, Dept Radiol, Med Ctr, Pittsburgh, PA USA.
C3 University of California System; University of California San Francisco;
   University of Washington; University of Washington Seattle; Joint Clinic
   Research Center - United Arab Emirates; Makerere University;
   Pennsylvania Commonwealth System of Higher Education (PCSHE); University
   of Pittsburgh
RP Shakil, SS (corresponding author), Univ Calif San Francisco, Dept Med, Div Cardiol, San Francisco, CA 94118 USA.
EM saate.shakil@ucsf.edu
RI Bittencourt, Marcio/C-1444-2011
OI Kityo, Cissy/0000-0002-9286-7052; Longenecker, Chris/0000-0002-9468-0179
FU National Institutes of Health [T32HL007828, 1K01HL147723, P30AI027757,
   K23HL123341]
FX This work was supported in part by the National Institutes of Health
   (T32HL007828 to SSS, 1K01HL147723 and P30AI027757 to TMT, and
   K23HL123341 to CTL).
CR Alencherry B, 2019, OPEN HEART, V6, DOI 10.1136/openhrt-2019-001046
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   Goff DC Jr, 2014, CIRCULATION, V129, pS49, DOI 10.1161/01.cir.0000437741.48606.98
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NR 11
TC 0
Z9 0
U1 0
U2 0
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
EI 1756-0500
J9 BMC RES NOTES
JI BMC Res. Notes
PD JUN 19
PY 2023
VL 16
IS 1
AR 107
DI 10.1186/s13104-023-06385-0
PG 6
WC Biology; Multidisciplinary Sciences
WE Emerging Sources Citation Index (ESCI)
SC Life Sciences & Biomedicine - Other Topics; Science & Technology - Other
   Topics
GA J6PX9
UT WOS:001010829700003
PM 37337285
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Nakamura, K
   Yamagishi, S
   Inoue, H
AF Nakamura, K
   Yamagishi, S
   Inoue, H
TI Unique atheroprotective property of azeinidipine, a
   dihydropyridine-based calcium antagonist
SO MEDICAL HYPOTHESES
LA English
DT Article
ID INSULIN-RESISTANCE; ALPHA; STRESS
AB Insulin resistance and central obesity are often associated with hypertension. The metabolic syndrome is a cluster of these common clinical disorders, and is related with an increased risk for cardiovascular diseases. A number of pro-inflammatory cytokines derived from adipose tissues have been thought to contribute to the development of insulin resistance and accelerated atherosclerosis. Among them, TNF-alpha has been most widely studied; it not only suppresses the insulin signaling, but also elicits vascular inflammation. Indeed, inhibition of TNF-alpha was found to improve insulin resistance in obese rats and reduce the progression of atherosclerosis in apolipoprotein E knockout mice, respectively. These observations demonstrate that TNF-alpha could play a central role in the pathogenesis of insulin resistance and accelerated atherosclerosis in the metabolic syndrome. Considering that the primary goals of treatment for hypertensive patients with the metabolic syndrome are prevention of the development of diabetes and cardiovascular events, anti-hypertensive drugs that have abilities to block the TNF-alpha signaling would be desirable as a first-line therapy for these patients. In the process of the search for such a unique anti-hypertensive drug, we have recently found that azelnidipine, a newly developed and commercially used long-acting dihydropyridine-based calcium antagonist (DHP), inhibited TNF-alpha-induced activator protein-1 activation and interteukin-8 expression in human umbilical vein endothelial cells by suppressing NADPH oxidase-mediated reactive oxygen species generation. The concentration of azelnidipine that was found effective in these in vitro-experiments is well within the therapeutic range. Since endothelial cells do not possess voltage-operated L-type calcium channels, these observations suggest that the beneficial effects of azelnidipine are not likely due to calcium channel blocking property, but due to its unique anti-oxidative ability. Furthermore, we have very recently found that serum levels of monocyte chemoattractant protein-1, a biomarker for subclinical atherosclerosis, were significantly decreased by the treatment of azelnidipine in patients with essential hypertension. In this paper, we would like to hypothesize that due to its unique TNF-alpha signal modulatory, anti-oxidative property, azelnidipine may be a promising DHP that targets diabetes and cardiovascular diseases in hypertensive patients with the metabolic syndrome. (c) 2005 Elsevier Ltd. All rights reserved.
C1 Kurume Univ, Sch Med, Dept Med, Kurume, Fukuoka 8300011, Japan.
   Kurume Univ, Sch Med, Radioisotope Inst Basic & Clin Med, Kurume, Fukuoka 8300011, Japan.
C3 Kurume University; Kurume University
RP Kurume Univ, Sch Med, Dept Med, 67 Asahi Machi, Kurume, Fukuoka 8300011, Japan.
EM shoichi@med.kurume-u.ac.jp
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NR 14
TC 9
Z9 13
U1 0
U2 1
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0306-9877
EI 1532-2777
J9 MED HYPOTHESES
JI Med. Hypotheses
PY 2005
VL 65
IS 1
BP 155
EP 157
DI 10.1016/j.mehy.2004.12.007
PG 3
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 932DW
UT WOS:000229535400027
PM 15893134
DA 2025-06-11
ER

PT J
CA FLAT-SUGAR Trial Investigators
TI Glucose Variability in a 26-Week Randomized Comparison of Mealtime
   Treatment With Rapid-Acting Insulin Versus GLP-1 Agonist in Participants
   With Type 2 Diabetes at High Cardiovascular Risk
SO DIABETES CARE
LA English
DT Article
ID RECEPTOR AGONIST; BASAL INSULIN; OPEN-LABEL; EXENATIDE; COMPLICATIONS;
   METFORMIN; TRIAL; TWICE
AB OBJECTIVEA1C is associated with diabetes complications but does not reflect glycemic variability (GV), which may worsen outcomes by inducing inflammation, oxidative stress, and cardiac arrhythmias. We tested whether a glucagon-like peptide 1 agonist-based regimen can reduce GV and cardiometabolic risk markers while maintaining similar A1C levels in people with insulin-requiring type 2 diabetes and high cardiovascular risk.RESEARCH DESIGN AND METHODSAfter run-in on metformin and basal-bolus insulin (BBI), 102 participants continued metformin and basal insulin and were randomized to exenatide dosing before the two largest meals (glucacon-like peptide-1 receptor agonist and insulin [GLIPULIN group]) or continuation of rapid-acting insulin analogs (BBI group). Indices of GV by continuous glucose monitoring (CGM), hypoglycemia, weight, risk markers, and cardiac arrhythmias were assessed. The primary end point was change in glucose coefficients of variation (CV) by CGM from baseline to 26 weeks.RESULTSAt randomization, the median A1C was 7.3% (57 mmol/mol) for GLIPULIN and 7.4% (56.3 mmol/mol) for BBI, and glucose CVs were 30.3 for BBI and 31.9 for GLIPULIN. At 26 weeks, A1C levels were similar (7.1% [54 mmol/mol] vs. 7.2% [55 mmol/mol]), whereas mean CV improved with GLIPULIN (-2.4 vs. 0.4, P = 0.047). Other GV indices followed similar nonsignificant patterns of improvement with GLIPULIN. There were no differences in hypoglycemic events during CGM or arrhythmias during electrocardiographic monitoring. On-trial changes in body weight (-4.8 kg vs. +0.7 kg, P < 0.001), alanine aminotransferase (P = 0.0002), and serum amyloid A (P = 0.023) favored GLIPULIN.CONCLUSIONSGLIPULIN reduced GV, weight, and some cardiometabolic risk markers while maintaining equivalent A1C levels versus BBI and might improve clinical outcomes in a larger trial.
RI O'Brien, Kevin/HDO-1461-2022
OI O'Brien, Kevin/0000-0002-2293-9196
FU Sanofi; Clinical Trials Service Unit of the University of Washington;
   Bristol-Myers Squibb-AstraZeneca; Eli Lilly; Bayer; Halozyme;
   AstraZeneca; Novo Nordisk
FX This study is an investigator-initiated clinical trial primarily funded
   by a grant from Sanofi. A contract was developed between Sanofi and the
   Clinical Trials Service Unit of the University of Washington, which
   became the academic sponsor of the study. Supplemental funding was
   provided later in the study by grants from Bristol-Myers
   Squibb-AstraZeneca and Sanofi. In-kind donations were provided for the
   study by several organizations, including Sanofi (donated insulin
   glargine [Lantus] and insulin glulisine [Apidra] and purchased insulin
   aspart [NovoLog]), Eli Lilly (donated insulin lispro [Humalog]),
   Amylin/Bristol-Myers Squibb-AstraZeneca (donated exenatide [Byetta]),
   Bayer (donated Contour Glucose Meters, strips, and supplies), Becton
   Dickinson (donated pen needles), Dexcom (donated the various components
   of the CGM devices [Seven Plus and Gen 4]), and Medicomp (donated Holter
   monitoring equipment and supported reading of the recordings). J.L.P.
   reports honoraria for consulting from Sanofi and research grant support
   from Sanofi, Bristol-Myers Squibb-AstraZeneca, Eli Lilly, and Bayer.
   These dualities of interest have been reviewed by the University of
   Washington. The FLAT-SUGAR Trial Investigators report receiving
   honoraria for consulting from Roche, Abbott Diabetes Care, and Becton
   Dickinson and receiving grants from Sanofi and Halozyme. R.B. reports
   receiving honoraria for consulting and lectures from Abbott Diabetes
   Care, Bayer, Boehringer Ingelheim, Bristol-Myers Squibb-AstraZeneca,
   Calibra, Eli Lilly, Halozyme, Hygieia, Johnson & Johnson, Medtronic,
   Novo Nordisk, Roche, Sanofi, Takeda, and Valeritas. C.K. reports having
   received grant support from Sanofi and Bristol-Myers Squibb-AstraZeneca.
   D.K. and K.R.B. report having received grant support from Sanofi. M.R.
   reports having received grant support from Sanofi, AstraZeneca, Eli
   Lilly, and Novo Nordisk; honoraria for speaking from Sanofi; and
   honoraria for consulting from Sanofi, AstraZeneca, Eli Lilly, Elcelyx,
   Valeritas, and Biodol; these dualities of interest have been reviewed
   and managed by Oregon Health & Science University. K.D.O. reports having
   received grant support from Sanofi for this study. No other potential
   conflicts of interest relevant to this article were reported.
CR [Anonymous], NEW ENGL J MED
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NR 20
TC 90
Z9 90
U1 0
U2 7
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0149-5992
EI 1935-5548
J9 DIABETES CARE
JI Diabetes Care
PD JUN
PY 2016
VL 39
IS 6
BP 973
EP 981
DI 10.2337/dc15-2782
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA DN3RJ
UT WOS:000376980500023
PM 27208320
DA 2025-06-11
ER

PT J
AU Bo, S
   Musso, G
   Gambino, R
   Villois, P
   Gentile, L
   Durazzo, M
   Cavallo-Perin, P
   Cassader, M
AF Bo, Simona
   Musso, Giovanni
   Gambino, Roberto
   Villois, Paola
   Gentile, Luigi
   Durazzo, Marilena
   Cavallo-Perin, Paolo
   Cassader, Maurizio
TI Prognostic implications for insulin-sensitive and insulin-resistant
   normal-weight and obese individuals from a population-based cohort
SO AMERICAN JOURNAL OF CLINICAL NUTRITION
LA English
DT Article
ID BODY-MASS INDEX; JAPANESE METABOLICALLY OBESE; HOMEOSTASIS MODEL
   ASSESSMENT; CARDIOVASCULAR RISK PROFILE; OXIDATIVE STRESS; HEALTHY;
   PREVALENCE; PHENOTYPES; DISEASE; GLUCOSE
AB Background: There are few prospective data on the prognosis of insulin-sensitive and insulin-resistant normal-weight (NW) or obese individuals.
   Objectives: The estimated liver fat content, incidences of hyperglycemia and cardiovascular disease, and all-cause and cardiovascular mortality rates were investigated in a population-based cohort of 1658 individuals who were categorized according to BMI and insulin resistance as defined by HOMA-IR values >= 2.5 and the presence of metabolic syndrome.
   Design: This was a prospective cohort study with a 9-y follow-up. Anthropometric values, blood pressure, and blood metabolic variables were measured, and information on vital status was collected from demographic files at follow-up.
   Results: A total of 137 of 677 NW individuals (20%) were classified as insulin resistant and normal weight (IR-NW), and 72 of 330 obese individuals (22%) were classified as insulin sensitive and obese (IS-obese). Incidences of diabetes, impaired fasting glucose, and cardiovascular events were 0.4%, 6.3%, and 3.3%, respectively, in insulin-sensitive and normal-weight (IS-NW) individuals (reference category); 5.8%, 10.2%, and 6.6%, respectively, in IR-NW individuals; and 5.6%, 8.3%, and 8.3%, respectively, in IS-obese individuals. In a multiple logistic regression model, risks of incident hyperglycemia and cardiovascular events increased in both groups compared with in the reference category [HR (95% CI): 2.54 (1.42, 4.55) and 1.98 (0.86, 4.54) in IR-NW subjects; 2.16 (1.01, 4.63) and 2.76 (1.05, 7.28) in IS-obese subjects]. The estimated liver fat content significantly increased during follow-up only in the IR-NW group in the same model. Cardiovascular mortality was 2-3-fold higher in IR-NW and IS-obese than in IS-NW individuals in a Cox regression model.
   Conclusions: Our data refute the existence of healthy obese phenotypes because IS-obese individuals showed increased cardiometabolic risk. The existence of unhealthy NW phenotypes is supported by their increased risk of incident hyperglycemia, fatty liver, cardiovascular events, and death. Am J Clin Nutr 2012;96:962-9.
C1 [Bo, Simona; Gambino, Roberto; Villois, Paola; Durazzo, Marilena; Cavallo-Perin, Paolo; Cassader, Maurizio] Univ Turin, Dept Internal Med, Corso Dogliotti 14, I-10126 Turin, Italy.
   [Musso, Giovanni] Gradenigo Hosp, Turin, Italy.
   [Gentile, Luigi] Hosp Asti, Diabet Clin, Asti, Italy.
C3 University of Turin; Humanitas Hospital Gradenigo
RP Bo, S (corresponding author), Univ Turin, Dept Internal Med, Corso Dogliotti 14, I-10126 Turin, Italy.
EM sbo@molinette.piemonte.it
RI Bo, Simona/AAC-1110-2019; GAMBINO, Roberto/AAC-7517-2022; Musso,
   Giovanni/AAB-7884-2022
OI DURAZZO, Marilena/0000-0003-2450-5911; Bo, Simona/0000-0001-6862-8628
FU Regione Piemonte
FX Supported by a grant from the Regione Piemonte, 2009.
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NR 49
TC 46
Z9 48
U1 0
U2 11
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0002-9165
EI 1938-3207
J9 AM J CLIN NUTR
JI Am. J. Clin. Nutr.
PD NOV
PY 2012
VL 96
IS 5
BP 962
EP 969
DI 10.3945/ajcn.112.040006
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 062UX
UT WOS:000312949600004
PM 23034958
OA Bronze
DA 2025-06-11
ER

PT J
AU Cabre, HE
   Woolf, EK
   Redman, LM
AF Cabre, Hannah E.
   Woolf, Emily K.
   Redman, Leanne M.
TI Precision Nutrition for Management of Cardiovascular Disease Risk during
   Menopause
SO LIFESTYLE GENOMICS
LA English
DT Review
DE Perimenopause; Postmenopause; Dietary Approaches to Stop Hypertension;
   Mediterranean diet; Diabetes
ID LOW-FAT; BODY-COMPOSITION; WOMENS HEALTH; WEIGHT-LOSS; CARBOHYDRATE
   DIETS; MEDITERRANEAN DIET; TRANSITION; ASSOCIATION; OBESITY;
   INTERVENTION
AB Background: Women can spend up to 40% of their lives in the postmenopausal state. As women begin to transition into menopause, known as perimenopause, changes in hormonal concentrations and body composition dramatically increase overall cardiometabolic risk. Dietary patterns and interventions can be utilized to prevent and treat cardiovascular disease (CVD) and some dietary patterns over others may be more beneficial due to their specific effects on the health aspects of menopause. In this narrative review, we summarize key cardiovascular alterations that occur during the menopause transition and explore current dietary recommendations to address CVD risk as well as explore the new frontier of precision nutrition and the implications for nutrition prescription during menopause. Summary: Popular dietary interventions for CVD such as the Dietary Approaches to Stop Hypertension (DASH) diet and the Mediterranean diet (MED) have limited data in women following menopause. However, both diets improve CVD risk biomarkers of total cholesterol and low-density lipoprotein cholesterol as well as lower oxidative stress and inflammation and improve endothelial function. As the menopause transition increases the risk for developing metabolic syndrome, insulin insensitivity, and dyslipidemia, the DASH diet and MED may be impactful dietary strategies for mediating CVD risk in menopausal women. However, these are "one-size-fits-all" approaches that neglect individual characteristics such as genetic predisposition and environmental factors. Precision nutrition considers individual factors for nutrition prescription, spanning from evaluating food intake preferences and behaviors to deep phenotyping. Data from a large-scale investigation of the menopause transition suggests nutritional strategies that address postprandial glycemic responses, and the gut microbiome may attenuate some of the unfavorable effects of menopause on CVD risk factors. Key Messages: Considering menopause, women are a clinical population that would greatly benefit from precision nutrition. Future research should explore the use of machine learning and artificial intelligence in a precision nutrition framework to modify the DASH diet and MED to address adverse effects that occur during the menopause transition are vital for supporting women's health as they age. (c) 2024 The Author(s).Published by S. Karger AG, Basel
C1 [Cabre, Hannah E.; Woolf, Emily K.; Redman, Leanne M.] Pennington Biomed Res Ctr, Reprod Endocrinol & Womens Hlth Lab, Baton Rouge, LA 70808 USA.
C3 Louisiana State University System; Louisiana State University;
   Pennington Biomedical Research Center
RP Redman, LM (corresponding author), Pennington Biomed Res Ctr, Reprod Endocrinol & Womens Hlth Lab, Baton Rouge, LA 70808 USA.
EM leanne.redman@pbrc.edu
RI Cabre, Hannah/NDT-4907-2025; Redman, Leanne/N-1986-2017
FU National Institute of Diabetes and Digestive and Kidney Diseases of the
   National Institutes of Health [T32DK064584]; Eunice Kennedy Shriver
   National Institute of Child Health and Human Development
   [5UG1HD107696-03]
FX Research reported in this publication was supported by the National
   Institute of Diabetes and Digestive and Kidney Diseases of the National
   Institutes of Health under Award No. T32DK064584 and Eunice Kennedy
   Shriver National Institute of Child Health and Human Development under
   Award No. 5UG1HD107696-03. The content is solely the responsibility of
   the authors and does not necessarily represent the official views of the
   National Institutes of Health. The funders had no role in the design,
   data collection, data analysis, and reporting of this review.
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NR 52
TC 1
Z9 1
U1 5
U2 7
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 2504-3161
EI 2504-3188
J9 LIFESTYLE GENOM
JI Lifestyle Genom.
PD JAN-DEC
PY 2024
VL 17
IS 1
BP 93
EP 101
DI 10.1159/000540337
PG 9
WC Genetics & Heredity; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Genetics & Heredity; Nutrition & Dietetics
GA O5D9J
UT WOS:001371341700001
PM 39047690
OA gold
DA 2025-06-11
ER

PT J
AU Das, M
   Sauceda, C
   Webster, NJG
AF Das, Manasi
   Sauceda, Consuelo
   Webster, Nicholas J. G.
TI Mitochondrial Dysfunction in Obesity and Reproduction
SO ENDOCRINOLOGY
LA English
DT Review
DE mitochondrial function; mitochondrial dynamics; lipid accumulation;
   oxidative stress; mitophagy; insulin resistance; ovarian dysfunction
ID INDUCED INSULIN-RESISTANCE; HUMAN SKELETAL-MUSCLE; PROTEIN-KINASE-C;
   FREE FATTY-ACID; PREMATURE OVARIAN FAILURE; OXYGEN SPECIES PRODUCTION;
   MATERNAL OBESITY; OXIDATIVE STRESS; METABOLIC SYNDROME; PERRAULT
   SYNDROME
AB Mounting evidence suggests a role for mitochondrial dysfunction in the pathogenesis of many diseases, including type 2 diabetes, aging, and ovarian failure. Because of the central role of mitochondria in energy production, heme biosynthesis, calcium buffering, steroidogenesis, and apoptosis signaling within cells, understanding the molecular mechanisms behind mitochondrial dysregulation and its potential implications in disease is critical. This review will take a journey through the past and summarize what is known about mitochondrial dysfunction in various disorders, focusing on metabolic alterations and reproductive abnormalities. Evidence is presented from studies in different human populations, and rodents with genetic manipulations of pathways known to affect mitochondrial function.
C1 [Das, Manasi; Sauceda, Consuelo; Webster, Nicholas J. G.] VA San Diego Healthcare Syst, San Diego, CA 92161 USA.
   [Das, Manasi; Sauceda, Consuelo; Webster, Nicholas J. G.] Univ Calif San Diego, Dept Med, Div Endocrinol & Metab, La Jolla, CA 92093 USA.
   [Webster, Nicholas J. G.] Univ Calif San Diego, Moores Canc Ctr, La Jolla, CA 92037 USA.
C3 US Department of Veterans Affairs; Veterans Health Administration (VHA);
   VA San Diego Healthcare System; University of California System;
   University of California San Diego; University of California System;
   University of California San Diego
RP Webster, NJG (corresponding author), Univ Calif San Diego, Dept Med, 9500 Gilman Dr, La Jolla, CA 92093 USA.
EM nwebster@ucsd.edu
RI Webster, Nick/AAI-8410-2021
OI Webster, Nicholas/0000-0002-3827-5750
FU VA Merit Review award [I01BX000130, I01BX004848]; Senior Research Career
   Scientist Award; National Institutes of Health [HD012303, CA196853,
   AI25860, HL141999]
FX This work was supported by a VA Merit Review award (I01BX000130 and
   I01BX004848), a Senior Research Career Scientist Award (to N.J.G.W.),
   and the National Institutes of Health (Grants Nos. HD012303, CA196853,
   AI25860, and HL141999 to N. J.G.W.)
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NR 156
TC 50
Z9 54
U1 2
U2 17
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0013-7227
EI 1945-7170
J9 ENDOCRINOLOGY
JI Endocrinology
PD JAN
PY 2021
VL 162
IS 1
AR bqaa158
DI 10.1210/endocr/bqaa158
PG 13
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA PQ4UF
UT WOS:000606540000006
PM 32945868
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Walsh, SW
AF Walsh, Scott W.
TI Obesity: a risk factor for preeclampsia
SO TRENDS IN ENDOCRINOLOGY AND METABOLISM
LA English
DT Review
ID BODY-MASS-INDEX; NECROSIS-FACTOR-ALPHA; OXIDATIVE STRESS; WEIGHT-LOSS;
   ENDOTHELIAL DYSFUNCTION; INFLAMMATORY MARKERS; DENSITY-LIPOPROTEIN;
   METABOLIC SYNDROME; BLOOD-PRESSURE; WOMEN
AB Obesity is becoming an epidemic worldwide. Among young women, obesity is especially important because maternal obesity confers an increased risk of preeclampsia, a hypertensive disorder of pregnancy and a leading cause of maternal and fetal morbidity and mortality. It is not known why obesity is a risk factor for preeclampsia, but these conditions might be related through common features related to oxidative stress, inflammation and altered vascular function. Recently, extensive vascular infiltration of neutrophils and vascular inflammation has been reported in both preeclamptic women and obese women. Therefore, if the vasculature of obese women is inflamed, they could be at increased risk of developing preeclampsia when they become pregnant and are exposed to the additional burdens of pregnancy.
C1 [Walsh, Scott W.] Virginia Commonwealth Univ, Med Ctr, Dept Obstet & Gynecol, Richmond, VA 23298 USA.
   [Walsh, Scott W.] Virginia Commonwealth Univ, Med Ctr, Dept Physiol, Richmond, VA 23298 USA.
C3 Virginia Commonwealth University; Virginia Commonwealth University
RP Walsh, SW (corresponding author), Virginia Commonwealth Univ, Med Ctr, Dept Obstet & Gynecol, Med Coll Virginia Campus, Richmond, VA 23298 USA.
EM swwalsh@vcu.edu
FU NHLBI NIH HHS [R01 HL069851] Funding Source: Medline
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NR 68
TC 118
Z9 132
U1 0
U2 6
PU ELSEVIER SCIENCE LONDON
PI LONDON
PA 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND
SN 1043-2760
EI 1879-3061
J9 TRENDS ENDOCRIN MET
JI Trends Endocrinol. Metab.
PD DEC
PY 2007
VL 18
IS 10
BP 365
EP 370
DI 10.1016/j.tem.2007.09.003
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 242PO
UT WOS:000251738000001
PM 18023357
DA 2025-06-11
ER

PT J
AU Porras, D
   Nistal, E
   Martínez-Flórez, S
   Pisonero-Vaquero, S
   Olcoz, JL
   Jover, R
   González-Gallego, J
   García-Mediavilla, MV
   Sánchez-Campos, S
AF Porras, David
   Nistal, Esther
   Martinez-Florez, Susana
   Pisonero-Vaquero, Sandra
   Luis Olcoz, Jose
   Jover, Ramiro
   Gonzalez-Gallego, Javier
   Victoria Garcia-Mediavilla, Maria
   Sanchez-Campos, Sonia
TI Protective effect of quercetin on high-fat diet-induced non-alcoholic
   fatty liver disease in mice is mediated by modulating intestinal
   microbiota imbalance and related gut-liver axis activation
SO FREE RADICAL BIOLOGY AND MEDICINE
LA English
DT Article
DE CYP2E1; Dysbiosis; Endoplasmic reticulum stress; Gut-liver axis;
   Inflammasome; Inflammation; Intestinal barrier function; Intestinal
   microbiota; Lipid metabolism; Lipotoxicity; NAFLD; Quercetin
ID HELICOBACTER-PYLORI INFECTION; ENDOPLASMIC-RETICULUM STRESS;
   CYTOCHROME-P450 2E1 CYP2E1; TOLL-LIKE RECEPTORS; OXIDATIVE STRESS;
   LIPID-ACCUMULATION; INSULIN-RESISTANCE; DOWN-REGULATION; CROSS-TALK;
   ER-STRESS
AB Gut microbiota is involved in obesity, metabolic syndrome and the progression of nonalcoholic fatty liver disease (NAFLD). It has been recently suggested that the flavonoid quercetin may have the ability to modulate the intestinal microbiota composition, suggesting a prebiotic capacity which highlights a great therapeutic potential in NAFLD. The present study aims to investigate benefits of experimental treatment with quercetin on gut microbial balance and related gut-liver axis activation in a nutritional animal model of NAFLD associated to obesity. C57BL/6J mice were challenged with high fat diet (HFD) supplemented or not with quercetin for 16 weeks. HFD induced obesity, metabolic syndrome and the development of hepatic steatosis as main hepatic histological finding. Increased accumulation of intrahepatic lipids was associated with altered gene expression related to lipid metabolism, as a result of deregulation of their major modulators. Quercetin supplementation decreased insulin resistance and NAFLD activity score, by reducing the intrahepatic lipid accumulation through its ability to modulate lipid metabolism gene expression, cytochrome P450 2E1 (CYP2E1)-dependent lipoperoxidation and related lipotoxicity. Microbiota composition was determined via 16S ribosomal RNA Illumina next-generation sequencing. Metagenomic studies revealed HFD-dependent differences at phylum, class and genus levels leading to dysbiosis, characterized by an increase in Firmicutes/Bacteroidetes ratio and in Gram-negative bacteria, and a dramatically increased detection of Helicobacter genus. Dysbiosis was accompanied by endotoxemia, intestinal barrier dysfunction and gut-liver axis alteration and subsequent inflammatory gene overexpression. Dysbiosis-mediated toll-like receptor 4 (TLR-4)-NF-kappa B signaling pathway activation was associated with inflammasome initiation response and reticulum stress pathway induction. Quercetin reverted gut microbiota imbalance and related endotoxemia-mediated TLR-4 pathway induction, with subsequent inhibition of inflammasome response and reticulum stress pathway activation, leading to the blockage of lipid metabolism gene expression deregulation. Our results support the suitability of quercetin as a therapeutic approach for obesity-associated NAFLD via its anti-inflammatory, antioxidant and prebiotic integrative response.
C1 [Porras, David; Nistal, Esther; Martinez-Florez, Susana; Pisonero-Vaquero, Sandra; Gonzalez-Gallego, Javier; Victoria Garcia-Mediavilla, Maria; Sanchez-Campos, Sonia] Univ Leon, Inst Biomed IBIOMED, Leon, Spain.
   [Luis Olcoz, Jose; Jover, Ramiro; Gonzalez-Gallego, Javier; Victoria Garcia-Mediavilla, Maria; Sanchez-Campos, Sonia] Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Hepat & Digest, Madrid, Spain.
   [Luis Olcoz, Jose] Complejo Asistencial Univ Leon, Dept Gastroenterol, Leon, Spain.
   [Jover, Ramiro] IIS Hosp La Fe, Expt Hepatol Unit, Valencia, Spain.
   [Jover, Ramiro] Univ Valencia, Dept Biochem & Mol Biol, Valencia, Spain.
C3 Universidad de Leon; Instituto de Salud Carlos III; CIBER - Centro de
   Investigacion Biomedica en Red; CIBEREHD; Universidad de Leon;
   University of Valencia
RP Sánchez-Campos, S (corresponding author), Univ Leon, Inst Biomed, Campus Vegazana, E-24071 Leon, Spain.
EM dporrs00@estudiantes.unileon.es; esthernistal@hotmail.com;
   smarf@unileon.es; spisv@unileon.es; jolcozg@gmail.com;
   ramiro.jover@uv.es; jgonga@unileon.es; mvgarm@unileon.es;
   ssanc@unileon.es
RI Porras, David/ABH-7475-2020; Gonzalez-Gallego, Javier/D-8219-2012;
   Nistal, Esther/ABL-5651-2022; Martínez Flórez, Susana/LKM-2602-2024;
   Garcia-Mediavilla, Victoria/F-9641-2015; Sanchez-Campos,
   Sonia/F-9654-2015; JOVER, RAMIRO/O-9796-2017
OI Martinez, Susana/0000-0002-7200-8744; Garcia-Mediavilla,
   Victoria/0000-0002-5722-7500; Porras, David/0000-0002-8824-7504;
   Sanchez-Campos, Sonia/0000-0003-2672-734X; Gonzalez-Gallego,
   Javier/0000-0002-4386-9342; Nistal, Esther/0000-0002-2201-5575; JOVER,
   RAMIRO/0000-0002-4914-5804
FU Ministerio de Economia y Competitividad/FEDER [BFU2013-48141-R]; Junta
   de Castilla y Leon [LE135U13, GRS1428/A/16, BIO/LE02/15]; Junta de
   Castilla y Leon y Fondo Europeo de Desarrollo Regional (FEDER)
   [LE063U16]; Fondo de Investigacion Sanitaria (FIS); Instituto de Salud
   Carlos III [ISCIII-FEDER PI 13/01470]; CIBERehd; Instituto de Salud
   Carlos III, Spain
FX This work was supported by grants to Javier Gonzalez-Gallego and Sonia
   Sanchez Campos from Ministerio de Economia y Competitividad/FEDER
   (BFU2013-48141-R) and Junta de Castilla y Leon (LE135U13, GRS1428/A/16
   and BIO/LE02/15), LE063U16 (Junta de Castilla y Leon y Fondo Europeo de
   Desarrollo Regional (FEDER)) and Ramiro Jover from Fondo de
   Investigacion Sanitaria (FIS), Instituto de Salud Carlos III
   (ISCIII-FEDER PI 13/01470). Maria V. Garcia-Mediavilla was supported by
   CIBERehd contracts. CIBERehd is funded by the Instituto de Salud Carlos
   III, Spain.
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NR 86
TC 397
Z9 424
U1 15
U2 317
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0891-5849
EI 1873-4596
J9 FREE RADICAL BIO MED
JI Free Radic. Biol. Med.
PD JAN
PY 2017
VL 102
BP 188
EP 202
DI 10.1016/j.freeradbiomed.2016.11.037
PG 15
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA EI3AG
UT WOS:000392361200016
PM 27890642
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Soltani, H
   Keim, NL
   Laugero, KD
AF Soltani, Hoda
   Keim, Nancy L.
   Laugero, Kevin D.
TI Waking Salivary Cortisol Associated with Magnitude of Cholesterol
   Reduction in Women Fed a Healthy Whole-Food Diet for 8 Weeks
SO CURRENT DEVELOPMENTS IN NUTRITION
LA English
DT Article
DE whole food diet intervention; cholesterol response; awakening cortisol
   phenotype; randomized control trial; women
ID STRESS; GLUCOCORTICOIDS; INSULIN; CARBOHYDRATE; METABOLISM; DISEASE;
   RISK; FAT
AB Background: Diet and cortisol are independently linked to cardiometabolic function and health, but underlying alterations in circulating cortisol may influence beneficial cardiometabolic effects of consuming a healthy diet.
   Objective: This study was a secondary analysis to examine whether baseline concentrations of waking salivary cortisol interacted with 8-wk whole-food diet interventions to affect cardiometabolic outcomes.
   Methods: A randomized, double-blind, controlled 8-wk diet intervention was conducted in 44 participants. The trial was conducted at the Western Human Nutrition Research Center in Davis, California. Participants were overweight or obese women aged 20-64 y, minimally active, and insulin resistant and/or dyslipidemic. Diets were randomly assigned and based on the 2010 Dietary Guidelines for Americans (DGA) or a typical American diet (TAD). Cardiometabolic risk factors and salivary cortisol were assessed at baseline and at 8 wk. Primary outcome measures included 8-wk change in overnight fasted cardiometabolic risk factors, including blood pressure, BMI, and circulating triglycerides, cholesterol, glycated hemoglobin (HbA1c), nonesterified fatty acids, and high-sensitivity C-reactive protein. This trial was approved by the University of California, Davis, Institutional Review Board.
   Results: Baseline waking cortisol concentrations interacted (P = 0.0474) with diet to affect 8-wk changes in fasting total cholesterol. Compared with a TAD, a DGA diet was associated with 8-wk decreases in total cholesterol in participants with low (10th percentile of all participants; 2.76 nmol/L) or average (7.76 nmol/L) but not higher (90th percentile of all participants; 13.44 nmol/L) baseline waking cortisol. Consistent with this finding, there was a DGA-specific positive association (P = 0.0047; b: 2.88 +/- 0.94) between baseline waking cortisol and 8-wk increases in total cholesterol.
   Conclusions: The underlying status of waking cortisol may explain interindividual variability in total cholesterol responses to whole-food diets.
C1 [Soltani, Hoda; Keim, Nancy L.; Laugero, Kevin D.] Univ Calif Davis, Dept Nutr, Davis, CA 95616 USA.
   [Keim, Nancy L.; Laugero, Kevin D.] ARS, Obes & Metab Res Unit, USDA, Western Human Nutr Res Ctr, Davis, CA 95616 USA.
C3 University of California System; University of California Davis; United
   States Department of Agriculture (USDA)
RP Laugero, KD (corresponding author), Univ Calif Davis, Dept Nutr, Davis, CA 95616 USA.; Laugero, KD (corresponding author), ARS, Obes & Metab Res Unit, USDA, Western Human Nutr Res Ctr, Davis, CA 95616 USA.
EM kevin.laugero@usda.gov
OI Keim, Nancy/0000-0002-6601-7572
FU USDA Agricultural Research Service project [2032-51530-022-00-D];
   National Dairy Council; Campbell Soup Company
FX Supported by funding from USDA Agricultural Research Service project
   2032-51530-022-00-D, the National Dairy Council, and the Campbell Soup
   Company.
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NR 29
TC 0
Z9 0
U1 2
U2 4
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 2475-2991
J9 CURR DEV NUTR
JI Curr. Dev. Nutr.
PD MAY 28
PY 2022
VL 6
IS 5
AR nzac083
DI 10.1093/cdn/nzac083
PG 8
WC Nutrition & Dietetics
WE Emerging Sources Citation Index (ESCI)
SC Nutrition & Dietetics
GA 1T0EI
UT WOS:000804412900001
PM 35669046
OA Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Lai, WJ
   Shi, M
   Huang, RS
   Fu, P
   Ma, L
AF Lai, Weijing
   Shi, Min
   Huang, Rongshuang
   Fu, Ping
   Ma, Liang
TI Fatty acid-binding protein 4 in kidney diseases: From mechanisms to
   clinics
SO EUROPEAN JOURNAL OF PHARMACOLOGY
LA English
DT Article
DE Kidney diseases; FABP4; Biomarker; Therapeutic target
ID ENDOPLASMIC-RETICULUM STRESS; METABOLIC SYNDROME; GAMMA ACTIVITY;
   ADIPOCYTE; INHIBITORS; LEVEL; CELLS; DRUG; IDENTIFICATION; CALCIFICATION
AB Considerable evidence indicated the relationship between fatty acid-binding protein 4 (FABP4) and kidney diseases. FABP4, a small molecular lipid chaperone, is identified to regulate fatty acid oxidation, inflammation, apoptosis, endoplasmic reticulum stress and macrophage-to-myofibroblast transition in kidney diseases. Many studies have shown that circulating FABP4 level is related to proteinuria, renal function decline, cardiovascular complications of end-stage renal disease and even the prognosis of kidney transplanted patients. Notably, pharmacological or genetic inhibition of FABP4 attenuated renal injury in the various experimental models of kidney diseases, making it promising to develop potential therapeutic strategies targeting FABP4 in kidney diseases. In this study, we updated and reviewed the mechanisms and clinical significance of FABP4 in kidney diseases.
C1 [Lai, Weijing; Shi, Min; Huang, Rongshuang; Fu, Ping; Ma, Liang] Sichuan Univ, West China Hosp, Kidney Res Inst, Dept Nephrol, Chengdu 610041, Sichuan, Peoples R China.
   [Lai, Weijing] Chengdu Med Coll, Affiliated Hosp 1, Clin Med Coll, Dept Nephrol, Chengdu 610500, Peoples R China.
   [Fu, Ping; Ma, Liang] Sichuan Univ, West China Hosp, Kidney Res Inst, Dept Nephrol, Guoxue Alley 37, Chengdu 610041, Peoples R China.
C3 Sichuan University; Chengdu Medical College; Sichuan University
RP Fu, P; Ma, L (corresponding author), Sichuan Univ, West China Hosp, Kidney Res Inst, Dept Nephrol, Guoxue Alley 37, Chengdu 610041, Peoples R China.
EM fupinghx@scu.edu.cn; liang_m@scu.edu.cn
RI Ma, Liang/AGS-5714-2022
OI Ma, Liang/0000-0001-8327-7969
FU National Key R & D Program of China [2020YFC2005000]; Science/Technology
   Project of Sichuan Province [2021YFQ0027]
FX Funding This study was supported by the National Key R & D Program of
   China (2020YFC2005000) and the Science/Technology Project of Sichuan
   Province (2021YFQ0027) .
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NR 102
TC 6
Z9 6
U1 2
U2 16
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0014-2999
EI 1879-0712
J9 EUR J PHARMACOL
JI Eur. J. Pharmacol.
PD SEP 15
PY 2022
VL 931
AR 175224
DI 10.1016/j.ejphar.2022.175224
EA AUG 2022
PG 7
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 4Y1WJ
UT WOS:000861322300001
PM 35995212
DA 2025-06-11
ER

PT J
AU Pistell, PJ
   Morrison, CD
   Gupta, S
   Knight, AG
   Keller, JN
   Ingram, DK
   Bruce-Keller, AJ
AF Pistell, Paul J.
   Morrison, Christopher D.
   Gupta, Sunita
   Knight, Alecia G.
   Keller, Jeffrey N.
   Ingram, Donald K.
   Bruce-Keller, Annadora J.
TI Cognitive impairment following high fat diet consumption is associated
   with brain inflammation
SO JOURNAL OF NEUROIMMUNOLOGY
LA English
DT Article
DE Metabolic syndrome; Neurodegeneration; Obesity; Oxidative stress;
   Western diet
ID NF-KAPPA-B; OXIDATIVE STRESS; LEPTIN RECEPTOR; METABOLIC COMPLICATIONS;
   GLUTAMATE RELEASE; DENTATE GYRUS; SATURATED FAT; OBESITY; HIPPOCAMPAL;
   EXPRESSION
AB C57Bl/6 truce were administered a high fat, Western diet (WD, 41% fat) or a very high fat lard diet (HFL, 60% fat). and evaluated I'm cognitive ability using the Stone T-maze and for biochemical markers of brain inflammation WD consumption resulted in significantly increased body weight and astrocyte reactivity. but not impaired cognition, microglial reactivity, or heightened cytokine levels. HFL. increased body weight. and impaired cognition. increased brain inflammation. and decreased BDNF. Collectively, these data suggest that while different diet formulations can increase body weight. the ability of high fat diets to disrupt cognition is linked to brain inflammation (C) 2009 Elsevier B V. All rights reserved
C1 [Pistell, Paul J.; Morrison, Christopher D.; Gupta, Sunita; Knight, Alecia G.; Keller, Jeffrey N.; Ingram, Donald K.; Bruce-Keller, Annadora J.] Louisiana State Univ Syst, Pennington Biomed Res Ctr, Baton Rouge, LA 70808 USA.
C3 Louisiana State University System; Louisiana State University;
   Pennington Biomedical Research Center
RP Bruce-Keller, AJ (corresponding author), Louisiana State Univ, Pennington Biomed Res Ctr, Inflammat & Neurodegenerat Lab, 6400 Perkins Rd, Baton Rouge, LA 70808 USA.
RI Keller, Jeffrey/N-1975-2017; Bruce-Keller, Annadora/N-1954-2017;
   Morrison, Christopher/A-6093-2010
OI Morrison, Christopher/0000-0002-5492-102X; keller,
   jeffrey/0000-0002-9892-7423
FU NIH [NS46267, DA19398, AG05119, NS051570, RR021945, P20-RR021945,
   P30-DK072476]
FX The authors are grateful to Megan Purpera and Sun-Ok FernandezKim for
   expert technical assistance and animal handling This work was supported
   by grants from the NIH (NS46267. DA19398, and AG05119 to AJB-K; NS051570
   and RR021945 to CDM). This study also used PBRC Core facilities (Animal
   Phenotyping) that are funded by the NIH (P20-RR021945 and P30-DK072476).
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NR 85
TC 469
Z9 529
U1 6
U2 77
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-5728
EI 1872-8421
J9 J NEUROIMMUNOL
JI J. Neuroimmunol.
PD FEB 26
PY 2010
VL 219
IS 1-2
BP 25
EP 32
DI 10.1016/j.jneuroim.2009.11.010
PG 8
WC Immunology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Neurosciences & Neurology
GA 570NA
UT WOS:000275683800004
PM 20004026
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Dancsó, B
   Spiró, Z
   Arslan, MA
   Nguyen, MT
   Papp, D
   Csermely, P
   Soti, C
AF Dancso, Balazs
   Spiro, Zoltan
   Arslan, Mehmet Alper
   Nguyen, Minh Tu
   Papp, Diana
   Csermely, Peter
   Soti, Csaba
TI The Heat Shock Connection of Metabolic Stress and Dietary Restriction
SO CURRENT PHARMACEUTICAL BIOTECHNOLOGY
LA English
DT Review
DE Aging; caloric restriction; diabetes; heat shock response; resveratrol;
   sirtuin
ID LIFE-SPAN EXTENSION; CALORIC RESTRICTION; CAENORHABDITIS-ELEGANS;
   MOLECULAR CHAPERONES; CELLULAR NETWORKS; IN-VIVO;
   DROSOPHILA-MELANOGASTER; TRANSCRIPTION FACTORS; ENDOCRINE REGULATION;
   INSULIN-RESISTANCE
AB Molecular chaperones and the heat shock response guard and modulate protein conformation, protect proteins from misfolding and aggregation, and maintain signalling and organellar networks. Overnutrition and the metabolic syndrome represent a pro-aging condition, and dietary restriction is the most robust environmental intervention that induces longevity from yeast to mammals. In recent years a considerable effort has been made to elucidate the signaling pathways involved in metabolic signaling. Here we review the current understanding on the connection between metabolic stress, dietary restriction and the heat shock response and highlight results showing chaperone induction as a promising therapeutic strategy to promote healthy aging and to prevent metabolic disorders.
C1 [Dancso, Balazs; Spiro, Zoltan; Arslan, Mehmet Alper; Nguyen, Minh Tu; Papp, Diana; Csermely, Peter; Soti, Csaba] Semmelweis Univ, Dept Med Chem, Budapest, Hungary.
C3 Semmelweis University
RP Soti, C (corresponding author), Semmelweis Univ, Dept Med Chem, Budapest, Hungary.
EM csaba.soti@eok.sote.hu
RI Csermely, Peter/J-2067-2017; Sőti, Csaba/O-6070-2017; Papp,
   Diana/K-3921-2015; Arslan, Mehmet Alper/HDO-4459-2022
OI Soti, Csaba/0000-0002-4057-7678; Papp, Diana/0000-0002-2732-7543; Papp,
   Diana/0000-0001-5001-5719; Csermely, Peter/0000-0001-9234-0659; Arslan,
   Mehmet Alper/0000-0002-3113-7195
FU EU [FP6-518230, PROTEOMAGE, FP7-200970, WhyWeAge]; Hungarian Science
   Foundation [OTKA K69105, NNF-78794]
FX Work in the authors' laboratory was supported by a research grant from
   the EU (FP6-518230, PROTEOMAGE; FP7-200970, WhyWeAge), from the
   Hungarian Science Foundation (OTKA K69105) and from a joint grant of the
   Hungarian Science Foundation and Norway Grants (NNF-78794). C. S. is a
   Bolyai Research Scholar of the Hungarian Academy of Sciences. The
   authors have declared that no competing interests exist.
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NR 107
TC 12
Z9 14
U1 1
U2 10
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1389-2010
EI 1873-4316
J9 CURR PHARM BIOTECHNO
JI Curr. Pharm. Biotechnol.
PD FEB
PY 2010
VL 11
IS 2
BP 139
EP 145
DI 10.2174/138920110790909704
PG 7
WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
GA 568IX
UT WOS:000275517100002
PM 20166967
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Poyraz, N
   Özer, H
   Baloglu, I
   Kadiyoran, C
   Yilmaz, PD
   Sertdemir, AL
   Türkmen, K
AF Poyraz, Necdet
   Ozer, Hakan
   Baloglu, Ismail
   Kadiyoran, Cengiz
   Yilmaz, Pinar Diydem
   Sertdemir, Ahmet Lutfu
   Turkmen, Kultigin
TI Liver-Spleen Ratio: Can It Be Used for the Prediction of Coronary Artery
   Disease?
SO ANATOLIAN JOURNAL OF CARDIOLOGY
LA English
DT Article
DE Liver-spleen ratio; hepatosteatosis; epicardial adipose tissue;
   cardiovascular disease
ID EPICARDIAL ADIPOSE-TISSUE; TO-LYMPHOCYTE RATIO; FATTY LIVER; METABOLIC
   SYNDROME; COMPUTED-TOMOGRAPHY; OXIDATIVE STRESS; THICKNESS; CT;
   DIAGNOSIS; OBESITY
AB Background: Considering that ectopic fat accumulation in various organs, especially the heart and liver, is a cardiometabolic risk factor, the need for easily accessible markers of ectopic fat accumulation is inevitable. The main starting point of the study is based on the hypothesis of predicting cardiovascular disease risk through the link that can be established between the liver-spleen ratio, which is one of the strong indicators of hepatosteatosis, and epicardial adipose tissue volume.
   Methods: This was a retrospective study. The records of 283 consecutive patients who underwent coronary computed tomography angiography in our Radiology Department were reviewed retrospectively from our hospital's system. All patients' epicardial adipose tissue volume and liver-spleen ratio were calculated using appropriate criteria on non-contrast computed tomography images. Additionally, the Coronary Artery Disease-Reporting and Data System was calculated on contrast computed tomography images. The participating patients were divided into groups according to the liver-spleen ratio and Coronary Artery Disease-Reporting and Data System score.
   Results: We found that while there was a negative correlation between the liver-spleen ratio and epicardial adipose tissue volume in the hepatosteatosis group, this relationship was not observed in the non-steatosis group. In addition, we observed that the family history of cardiovascular disease and the frequency of cardiovascular disease were higher in the hepatosteatosis group than in the other group, and there was a correlation between cardiovascular disease and the liver-spleen ratio. Also, we found that age and liver- spleen ratio values were found to be independent predictors of coronary artery disease.
   Conclusion: In our study, we found that the frequency of cardiovascular disease was lower in patients with a high liver-spleen ratio. We also demonstrated in the study that the liver-spleen ratio, which indicates a low level of epicardial adipose tissue volume accumulation, is an independent predictor of cardiovascular disease. In addition, the use of liver-spleen ratio, which is more valuable than liver attenuation in predicting hepatic steatosis, may be more useful in evaluating the risk of hepatosteatosis-related cardiovascular disease.
C1 [Poyraz, Necdet; Kadiyoran, Cengiz; Yilmaz, Pinar Diydem] Necmettin Erbakan Univ, Meram Fac Med, Dept Radiol, Konya, Turkey.
   [Ozer, Hakan; Turkmen, Kultigin] Necmettin Erbakan Univ, Meram Fac Med, Dept Nephrol, Konya, Turkey.
   [Baloglu, Ismail] Omer Halisdemir Univ Training & Res Hosp, Dept Nephrol, Nigde, Turkey.
   [Sertdemir, Ahmet Lutfu] Necmettin Erbakan Univ, Meram Fac Med, Dept Cardiol, Konya, Turkey.
C3 Necmettin Erbakan University; Necmettin Erbakan University; Nigde Omer
   Halisdemir University; Necmettin Erbakan University
RP Özer, H (corresponding author), Necmettin Erbakan Univ, Meram Fac Med, Dept Nephrol, Konya, Turkey.
EM hakanozer724@gmail.com
RI KADIYORAN, Cengiz/AAH-6564-2021; Turkmen, Kultigin/AFR-4244-2022;
   Poyraz, Necdet/AAP-2172-2020; Özer, Hakan/HKN-9433-2023; Yilmaz,
   Pinar/AAH-5763-2021
OI Yilmaz, Pinar Diydem/0000-0002-8519-5382; Turkmen,
   Kultigin/0000-0002-1667-7716; OZER, Hakan/0000-0001-9174-0351
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NR 60
TC 4
Z9 4
U1 0
U2 8
PU AVES
PI SISLI
PA BUYUKDERE CAD 105-9, MECIDIYEKOY, SISLI, ISTANBUL 34394, TURKEY
SN 2149-2263
EI 2149-2271
J9 ANATOL J CARDIOL
JI Anat. J. Cardiol.
PD OCT
PY 2022
VL 26
IS 10
BP 762
EP 770
DI 10.5152/AnatolJCardiol.2022.1787
PG 9
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 6D2UQ
UT WOS:000882552600005
PM 35943316
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Mahbouli, S
   Dupont, C
   Elfassy, Y
   Lameignère, E
   Levy, R
AF Mahbouli, Sinda
   Dupont, Charlotte
   Elfassy, Yaelle
   Lameignere, Eric
   Levy, Rachel
TI Exploring the potential impact of nutritionally actionable genetic
   polymorphisms on idiopathic male infertility: a review of current
   evidence
SO ASIAN JOURNAL OF ANDROLOGY
LA English
DT Review
ID SPERM DNA-DAMAGE; OXIDATIVE STRESS; NITRIC-OXIDE; VITAMIN-D; METABOLIC
   SYNDROME; APOLIPOPROTEIN-E; SEMINAL PLASMA; SELENIUM SUPPLEMENTATION;
   COMMON VARIANTS; INCREASED RISK
AB Infertility affects about 15% of the world's population. In 40%-50% of infertile couples, a male factor underlies the problem, but in about 50% of these cases, the etiology of male infertility remains unexplained. Some clinical data show that lifestyle interventions may contribute to male reproductive health. Cessation of unhealthy habits is suggested for preserving male fertility; there is growing evidence that most preexisting comorbidities, such as obesity and metabolic syndrome, are highly likely to have an impact on male fertility. The analysis of genetic polymorphisms implicated in metabolic activity represents one of the most exciting areas in the study of genetic causes of male infertility. Although these polymorphisms are not directly connected with male infertility, they may have a role in specific conditions associated with it, that is, metabolic disorders and oxidative stress pathway genes that are potentially associated with an increased risk of male infertility due to DNA and cell membrane damage. Some studies have examined the impact of individual genetic differences and gene-diet interactions on male infertility, but their results have not been synthesized. We review the current research to identify genetic variants that could be tested to improve the chances of conceiving spontaneously through personalized diet and/or oral vitamin and mineral supplementation, by examining the science of genetic modifiers of dietary factors that affect nutritional status and male fertility.
C1 [Mahbouli, Sinda; Lameignere, Eric] FabLife, 104 Ave Albert 1er, F-92500 Rueil Malmaison, France.
   [Dupont, Charlotte; Levy, Rachel] Sorbonne Univ, Tenon Hosp, AP HP, St Antoine Res Ctr,INSERM,Genet & Acquired Lipody, F-75020 Paris, France.
   [Dupont, Charlotte; Elfassy, Yaelle; Levy, Rachel] Tenon Hosp, AP HP, Reprod Biol & CECOS, F-75020 Paris, France.
C3 Assistance Publique Hopitaux Paris (APHP); Sorbonne Universite; Hopital
   Universitaire Tenon - APHP; Hopital Universitaire Saint-Antoine - APHP;
   Institut National de la Sante et de la Recherche Medicale (Inserm);
   Assistance Publique Hopitaux Paris (APHP); Sorbonne Universite; Hopital
   Universitaire Tenon - APHP
RP Levy, R (corresponding author), Sorbonne Univ, Tenon Hosp, AP HP, St Antoine Res Ctr,INSERM,Genet & Acquired Lipody, F-75020 Paris, France.; Levy, R (corresponding author), Tenon Hosp, AP HP, Reprod Biol & CECOS, F-75020 Paris, France.
EM rachel.levy@aphp.fr
RI Dupont, Charlotte/AAL-8780-2020
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U1 0
U2 6
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, Maharashtra, INDIA
SN 1008-682X
EI 1745-7262
J9 ASIAN J ANDROL
JI Asian J. Androl.
PD SEP-OCT
PY 2021
VL 23
IS 5
BP 441
EP 449
DI 10.4103/aja.aja_87_20
PG 9
WC Andrology; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Urology & Nephrology
GA WQ9SM
UT WOS:000714150100001
PM 33533736
OA gold, Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Danciu, AM
   Ghitea, TC
   Bungau, AF
   Vesa, CM
AF Danciu, Adrian Marius
   Ghitea, Timea Claudia
   Bungau, Alexa Florina
   Vesa, Cosmin Mihai
TI The Crucial Role of Diet Therapy and Selenium on the Evolution of
   Clinical and Paraclinical Parameters in Patients with Metabolic Syndrome
SO JOURNAL OF NUTRITION AND METABOLISM
LA English
DT Article
ID OXIDATIVE STRESS; ACNE-VULGARIS; MUSCLE STRENGTH; PATHOGENESIS;
   ANTIOXIDANTS; INFLAMMATION; INVOLVEMENT; QUALITY; ADULTS
AB Oxidative stress (OS) is associated with metabolic syndrome (MS) and represents a complex disease association that has become a major challenge in the field of public health. The aim of this study was to investigate the effectiveness of introducing selenium in the management of OS, while considering a balanced diet based on a healthy lifestyle and dietary therapy. A total of 206 individuals participated voluntarily in the study, divided into three groups: the control group with 35 individuals (17.0%) designated as control lot (LC), the group undergoing diet therapy with 119 individuals (57.8%) designated as diet therapy lot (LD), and the group undergoing diet therapy supplemented with selenium consisting of 52 individuals (25.2%) designated as diet therapy with selenium lot (LD + Se). The study assessed various clinical parameters (such as body mass index (BMI), body weight status, fat mass, visceral fat, and sarcopenic index), paraclinical parameters (including HOMA index, cholesterol, triglycerides, C-reactive protein, and glycosylated haemoglobin (HGS)), as well as OS parameters (measured using the FORD test, FORT test, and MIXED test). The LD + Se group demonstrated the most favourable results in terms of BMI reduction, decreased fat and visceral mass, reduced levels of C-reactive protein, and improved glycosylated haemoglobin levels. By implementing a balanced diet therapy and supplementing the diet with selenium, it was possible to achieve a reduction in adipose tissue and glycosylated haemoglobin levels, ultimately contributing to the reduction of OS in the body.
C1 [Danciu, Adrian Marius; Bungau, Alexa Florina] Univ Oradea, Doctoral Sch Biol & Biomed Sci, Oradea 410087, Romania.
   [Ghitea, Timea Claudia] Univ Oradea, Fac Med & Pharm, Pharm Dept, Oradea 410068, Romania.
   [Vesa, Cosmin Mihai] Univ Oradea, Fac Med & Pharm, Med Dept, Oradea 410068, Romania.
C3 University of Oradea; University of Oradea; University of Oradea
RP Bungau, AF (corresponding author), Univ Oradea, Doctoral Sch Biol & Biomed Sci, Oradea 410087, Romania.; Ghitea, TC (corresponding author), Univ Oradea, Fac Med & Pharm, Pharm Dept, Oradea 410068, Romania.
EM adrian.danciu@telios.ro; timea.ghitea@csud.uoradea.ro;
   pradaalexaflorina@gmail.com; v_cosmin_15@yahoo.com
RI Mihai, Vesa/AAE-5495-2019; Bungau, Alexa/AGY-4752-2022; Ghitea, Timea
   Claudia/AAJ-4273-2021
OI Cosmin Mihai, Vesa/0000-0001-5071-9601; Ghitea, Timea
   Claudia/0000-0001-8981-1958
FU The authors would like to thank the University of Oradea for supporting
   the payment of the invoice, through an internal project. The APC was
   funded by the University of Oradea, Oradea, Romania.; University of
   Oradea - University of Oradea; Oradea, Romania
FX The authors would like to thank the University of Oradea for supporting
   the payment of the invoice, through an internal project. The APC was
   funded by the University of Oradea, Oradea, Romania.
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NR 73
TC 2
Z9 2
U1 2
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2090-0724
EI 2090-0732
J9 J NUTR METAB
JI J. Nutr. Metab.
PD SEP 25
PY 2023
VL 2023
AR 6632197
DI 10.1155/2023/6632197
PG 14
WC Nutrition & Dietetics
WE Emerging Sources Citation Index (ESCI)
SC Nutrition & Dietetics
GA T3XS0
UT WOS:001077355200001
PM 37790730
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Francisqueti-Ferron, FV
   Silva, JPD
   Garcia, JL
   Ferron, AJT
   Kano, HT
   Silva, CCVD
   Costa, MR
   Nai, GA
   Moreto, F
   Corrêa, CR
AF Francisqueti-Ferron, Fabiane Valentini
   Silva, Janaina Paixao das Chagas
   Garcia, Jessica Leite
   Ferron, Artur Junio Togneri
   Kano, Hugo Tadashi
   Silva, Carol Cristina Vagula de Almeida
   Costa, Mariane Rovero
   Nai, Gisele Alborghetti
   Moreto, Fernando
   Correa, Camila Renata
TI Preventive Effect of Gamma-Oryzanol on Physiopathological Process
   Related to Nonalcoholic Fatty Liver Disease in Animals Submitted to High
   Sugar/Fat Diet
SO LIVERS
LA English
DT Article
DE nonalcoholic fatty liver disease; gamma-oryzanol; metabolic syndrome;
   bioactive compounds
AB Nonalcoholic fatty liver disease (NAFLD) is the main cause of liver disease. The physiopathological processes involved in the disease are metabolic syndrome (MetS) components (central obesity, dyslipidemia, insulin resistance/type 2 diabetes, hypertension), genetic, and dietary factors, including unsaturated fats and sweetened beverages, which are able to lead to inflammation and oxidative stress, conditions associated with progression and severity of NAFLD. Gamma-oryzanol (gamma Oz) is a nutraceutical obtained from rice brain oil with many benefits to health, from immunological to metabolic. The aim of this study is to test the preventive effect of gamma Oz on the physiopathological process related to nonalcoholic fatty liver disease in animals submitted to high sugar/fat diet. Male Wistar rats (+/- 187 g) were randomly divided into four experimental groups to receive: control diet (C, n = 6), control diet plus gamma Oz (C + gamma Oz, n = 6), high sugar/fat diet (HSF, n = 6), or high sugar/fat diet plus gamma Oz (HSF + gamma Oz, n = 6) during 30 weeks. HSF groups also received water plus sucrose (25%). gamma Oz was added to diets to reach 0.5% of final concentration. The HSF group presented MetS, liver inflammation and oxidative stress, and micro and macrovesicular steatosis. HSF plus gamma Oz was protected against these changes. It is possible to conclude that gamma-oryzanol was effective in modulating the physiopathological process related to nonalcoholic fatty liver disease in animals submitted to a high sugar/fat diet.
C1 [Francisqueti-Ferron, Fabiane Valentini; Garcia, Jessica Leite; Ferron, Artur Junio Togneri; Kano, Hugo Tadashi; Silva, Carol Cristina Vagula de Almeida; Costa, Mariane Rovero; Moreto, Fernando; Correa, Camila Renata] Sao Paulo State Univ UNESP, Med Sch, BR-18618687 Botucatu, SP, Brazil.
   [Silva, Janaina Paixao das Chagas] Sao Paulo State Univ UNESP, Inst Biosci, BR-18618687 Botucatu, SP, Brazil.
   [Nai, Gisele Alborghetti] Univ Oeste Paulista UNOESTE, Dept Pathol Anat & Cytopathol, BR-19050680 Presidente Prudente, SP, Brazil.
C3 Universidade Estadual Paulista; Universidade Estadual Paulista;
   Universidade do Oeste Paulista
RP Francisqueti-Ferron, FV (corresponding author), Sao Paulo State Univ UNESP, Med Sch, BR-18618687 Botucatu, SP, Brazil.
EM fabiane_vf@yahoo.com.br
RI Nai, Gisele/G-6810-2012; Correa, Camila/Q-2071-2019; Francisqueti-
   Ferron, Fabiane/M-4919-2017; Leite Garcia, Jessica/Q-8779-2018; Moreto,
   Fernando/I-7690-2013; Ferron, Artur Junio/M-5194-2017
OI Nai, Gisele/0000-0003-1674-7371; Vagula de Almeida Silva, Carol
   Cristina/0000-0001-9911-6254; Correa, Camila Renata/0000-0001-8493-5329;
   Kano, Hugo Tadashi/0000-0003-3938-4921; Francisqueti- Ferron,
   Fabiane/0000-0003-2910-4308; Leite Garcia, Jessica/0000-0002-3670-243X;
   Moreto, Fernando/0000-0002-4028-0014; Ferron, Artur
   Junio/0000-0001-7089-3033
FU Sao Paulo Research Foundation (FAPESP) [2015/10626-0, 2019/04524-0]
FX Sao Paulo Research Foundation (FAPESP), grant #2015/10626-0 and
   #2019/04524-0
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NR 31
TC 4
Z9 4
U1 0
U2 3
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2673-4389
J9 LIVERS-BASEL
JI Livers
PD SEP
PY 2022
VL 2
IS 3
BP 146
EP 157
DI 10.3390/livers2030013
PG 12
WC Gastroenterology & Hepatology
WE Emerging Sources Citation Index (ESCI)
SC Gastroenterology & Hepatology
GA WI4E4
UT WOS:001254219500001
OA gold
DA 2025-06-11
ER

PT J
AU Ghosh, S
   Dhar, S
   Bhattacharjee, S
   Bhattacharjee, P
AF Ghosh, Sunandini
   Dhar, Shrinjana
   Bhattacharjee, Sandip
   Bhattacharjee, Pritha
TI Contribution of environmental, genetic and epigenetic factors to
   obesity-related metabolic syndrome
SO NUCLEUS-INDIA
LA English
DT Review
DE Non-communicable diseases; Lifestyle; Environmental factors; Obesity;
   Genetics; Epigenetics
ID BODY-MASS INDEX; RENIN-ANGIOTENSIN SYSTEM; CORONARY-HEART-DISEASE;
   FOOD-INTAKE REGULATION; DNA METHYLATION; PHYSICAL-ACTIVITY;
   INSULIN-RESISTANCE; HIGH-FAT; ADIPOSE-TISSUE; WEIGHT-GAIN
AB Non-communicable lifestyle diseases and related mortality are increasing rapidly over the last few decades. Obesity is one of the major concerning problems leading to obesity-related metabolic syndrome like cardiovascular diseases, type 2 diabetes mellitus, polycystic ovarian syndrome etc. About 40-75% of obesity cases arise through genetic inheritance. The genetic and epigenetic alterations involved in the disease manifestation are controlled by the environmental factors including both physical and physiological factors. In both the prenatal and postnatal stages of the concerned individual, the epigenetic modifications are controlled by the environmental factors subsequently leading to genomic alterations and predisposition of a disease. In this review, we have assimilated the studies from last 20 years discussing the genetic and epigenetic mechanisms of the predominant non-communicable diseases and the environmental factors affecting them. This review also focuses on the inter-relationship of the concerned environmental factors and their variations in a disease specific pattern. The environmental factors including diet, physical inactivity, stress, education, pollutants, addictions etc. have been found to portray significant role in the disease outcomes. The family income, exposure to heavy metal pollutants, noise pollution, endocrine disruptors and external stress inducing agents can't be controlled by the subject. Instead, controlling the diet pattern, family health, sleeping duration, screen time, addiction of alcohol or smoking and physical activity can provide significant benefit henceforth lowering the risk of obesity, CVD, T2DM and PCOD.
C1 [Ghosh, Sunandini; Dhar, Shrinjana; Bhattacharjee, Pritha] Univ Calcutta, Dept Environm Sci, Environm Epigen Lab, 35 Ballygunge Circular Rd, Kolkata 700019, West Bengal, India.
   [Ghosh, Sunandini] Univ Calcutta, Dept Zool, 35 Ballygunge Circular Rd, Kolkata 700019, India.
   [Bhattacharjee, Sandip] Siemens India, Hlth Management Environm Hlth & Safety, Level 21,Plot 1080,Dr Annie Besant Rd, Mumbai 400030, India.
C3 University of Calcutta; University of Calcutta
RP Bhattacharjee, P (corresponding author), Univ Calcutta, Dept Environm Sci, Environm Epigen Lab, 35 Ballygunge Circular Rd, Kolkata 700019, West Bengal, India.
EM 777.pritha@gmail.com
RI Dhar, Shrinjana/MTA-3614-2025; bhattacharjee, pritha/I-5171-2019
OI Bhattacharjee, Pritha/0000-0002-4623-7746; Dhar,
   Shrinjana/0000-0002-2765-0439
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NR 254
TC 7
Z9 7
U1 0
U2 21
PU SPRINGER INDIA
PI NEW DELHI
PA 7TH FLOOR, VIJAYA BUILDING, 17, BARAKHAMBA ROAD, NEW DELHI, 110 001,
   INDIA
SN 0029-568X
EI 0976-7975
J9 NUCLEUS CALCUTTA
JI Nucleus
PD AUG
PY 2023
VL 66
IS 2
BP 215
EP 237
DI 10.1007/s13237-023-00420-y
EA APR 2023
PG 23
WC Cell Biology
WE Emerging Sources Citation Index (ESCI)
SC Cell Biology
GA K4QV9
UT WOS:000967152600001
DA 2025-06-11
ER

PT J
AU Zgutka, K
   Tkacz, M
   Tomasiak, P
   Tarnowski, M
AF Zgutka, Katarzyna
   Tkacz, Marta
   Tomasiak, Patrycja
   Tarnowski, Maciej
TI A Role for Advanced Glycation End Products in Molecular Ageing
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE AGE; ageing; oxidative stress; inflammation; brain; age-related
   diseases; caloric restriction; physical activities
ID CARDIOMETABOLIC RISK-FACTORS; INCREASED PROTEIN GLYCATION; REDUCES
   OXIDATIVE STRESS; LOW-DENSITY-LIPOPROTEIN; CALORIC RESTRICTION;
   EXTRACELLULAR-MATRIX; MAILLARD REACTION; SOLUBLE RECEPTOR; AGE
   ACCUMULATION; OXIDANT STRESS
AB Ageing is a composite process that involves numerous changes at the cellular, tissue, organ and whole-body levels. These changes result in decreased functioning of the organism and the development of certain conditions, which ultimately lead to an increased risk of death. Advanced glycation end products (AGEs) are a family of compounds with a diverse chemical nature. They are the products of non-enzymatic reactions between reducing sugars and proteins, lipids or nucleic acids and are synthesised in high amounts in both physiological and pathological conditions. Accumulation of these molecules increases the level of damage to tissue/organs structures (immune elements, connective tissue, brain, pancreatic beta cells, nephrons, and muscles), which consequently triggers the development of age-related diseases, such as diabetes mellitus, neurodegeneration, and cardiovascular and kidney disorders. Irrespective of the role of AGEs in the initiation or progression of chronic disorders, a reduction in their levels would certainly provide health benefits. In this review, we provide an overview of the role of AGEs in these areas. Moreover, we provide examples of lifestyle interventions, such as caloric restriction or physical activities, that may modulate AGE formation and accumulation and help to promote healthy ageing.
C1 [Zgutka, Katarzyna; Tkacz, Marta; Tarnowski, Maciej] Pomeranian Med Univ, Fac Hlth Sci, Dept Physiol Hlth Sci, Zolnierska 54, PL-70210 Szczecin, Poland.
   [Tomasiak, Patrycja] Univ Szczecin, Inst Phys Culture Sci, PL-70453 Szczecin, Poland.
C3 Pomeranian Medical University; University of Szczecin
RP Tarnowski, M (corresponding author), Pomeranian Med Univ, Fac Hlth Sci, Dept Physiol Hlth Sci, Zolnierska 54, PL-70210 Szczecin, Poland.
EM maciejt@pum.edu.pl
RI Tkacz, Marta/ABD-7770-2020; Tarnowski, Maciej/J-6292-2014; Zgutka,
   Katarzyna/M-8352-2014
OI Tarnowski, Maciej/0000-0002-3869-5077; Zgutka,
   Katarzyna/0000-0003-1445-6562
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WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA K3AT3
UT WOS:001015205600001
PM 37373042
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Akhter, N
   Wilson, A
   Arefanian, H
   Thomas, R
   Kochumon, S
   Al-Rashed, F
   Abu-Farha, M
   Al-Madhoun, A
   Al-Mulla, F
   Ahmad, R
   Sindhu, S
AF Akhter, Nadeem
   Wilson, Ajit
   Arefanian, Hossein
   Thomas, Reeby
   Kochumon, Shihab
   Al-Rashed, Fatema
   Abu-Farha, Mohamed
   Al-Madhoun, Ashraf
   Al-Mulla, Fahd
   Ahmad, Rasheed
   Sindhu, Sardar
TI Endoplasmic Reticulum Stress Promotes the Expression of TNF-α in THP-1
   Cells by Mechanisms Involving ROS/CHOP/HIF-1α and MAPK/NF-κB Pathways
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE ER stress; metabolic stress; obesity; metabolic syndrome; inflammation;
   TNF-alpha; ROS; CHOP; HIF-1 alpha; MAPK/NF-kappa B
ID TUMOR-NECROSIS-FACTOR; OXIDATIVE STRESS; ADIPOSE-TISSUE;
   INSULIN-RESISTANCE; FATTY-ACIDS; MONOCYTIC CELLS; UP-REGULATION;
   OLEIC-ACID; OBESITY; PROTEIN
AB Obesity and metabolic syndrome involve chronic low-grade inflammation called metabolic inflammation as well as metabolic derangements from increased endotoxin and free fatty acids. It is debated whether the endoplasmic reticulum (ER) stress in monocytic cells can contribute to amplify metabolic inflammation; if so, by which mechanism(s). To test this, metabolic stress was induced in THP-1 cells and primary human monocytes by treatments with lipopolysaccharide (LPS), palmitic acid (PA), or oleic acid (OA), in the presence or absence of the ER stressor thapsigargin (TG). Gene expression of tumor necrosis factor (TNF)-alpha and markers of ER/oxidative stress were determined by qRT-PCR, TNF-alpha protein by ELISA, reactive oxygen species (ROS) by DCFH-DA assay, hypoxia-inducible factor 1-alpha (HIF-1 alpha), p38, extracellular signal-regulated kinase (ERK)-1,2, and nuclear factor kappa B (NF-kappa B) phosphorylation by immunoblotting, and insulin sensitivity by glucose-uptake assay. Regarding clinical analyses, adipose TNF-alpha was assessed using qRT-PCR/IHC and plasma TNF-alpha, high-sensitivity C-reactive protein (hs-CRP), malondialdehyde (MDA), and oxidized low-density lipoprotein (OX-LDL) via ELISA. We found that the cooperative interaction between metabolic and ER stresses promoted TNF-alpha, ROS, CCAAT-enhancer-binding protein homologous protein (CHOP), activating transcription factor 6 (ATF6), superoxide dismutase 2 (SOD2), and nuclear factor erythroid 2-related factor 2 (NRF2) expression (p <= 0.0183),. However, glucose uptake was not impaired. TNF-alpha amplification was dependent on HIF-1 alpha stabilization and p38 MAPK/p65 NF-kappa B phosphorylation, while the MAPK/NF-kappa B pathway inhibitors and antioxidants/ROS scavengers such as curcumin, allopurinol, and apocynin attenuated the TNF-alpha production (p <= 0.05). Individuals with obesity displayed increased adipose TNF-alpha gene/protein expression as well as elevated plasma levels of TNF-alpha, CRP, MDA, and OX-LDL (p <= 0.05). Our findings support a metabolic-ER stress cooperativity model, favoring inflammation by triggering TNF-alpha production via the ROS/CHOP/HIF-1 alpha and MAPK/NF-kappa B dependent mechanisms. This study also highlights the therapeutic potential of antioxidants in inflammatory conditions involving metabolic/ER stresses.
C1 [Akhter, Nadeem; Wilson, Ajit; Arefanian, Hossein; Thomas, Reeby; Kochumon, Shihab; Al-Rashed, Fatema; Ahmad, Rasheed; Sindhu, Sardar] Dasman Diabet Inst, Dept Immunol & Microbiol, POB 1180, Dasman 15462, Kuwait.
   [Abu-Farha, Mohamed; Al-Mulla, Fahd] Dasman Diabet Inst, Dept Translat Res, POB 1180, Dasman 15462, Kuwait.
   [Al-Madhoun, Ashraf] Dasman Diabet Inst, Dept Genet & Bioinformat, POB 1180, Dasman 15462, Kuwait.
   [Al-Madhoun, Ashraf; Sindhu, Sardar] Dasman Diabet Inst, Anim & Imaging Core Facil, POB 1180, Dasman 15462, Kuwait.
C3 Dasman Diabetes Institute (DDI); Dasman Diabetes Institute (DDI); Dasman
   Diabetes Institute (DDI); Dasman Diabetes Institute (DDI)
RP Sindhu, S (corresponding author), Dasman Diabet Inst, Dept Immunol & Microbiol, POB 1180, Dasman 15462, Kuwait.; Sindhu, S (corresponding author), Dasman Diabet Inst, Anim & Imaging Core Facil, POB 1180, Dasman 15462, Kuwait.
EM nadeem.akhter@dasmaninstitute.org; ajit.wilson@dasmaninstitute.org;
   hossein.arefanian@dasmaninstitute.org; reeby.thomas@dasmaninstitute.org;
   shihab.kochumon@dasmaninstitute.org;
   fatema.alrashed@dasmaninstitute.org;
   mohamed.abufarha@dasmaninstitute.org;
   ashraf.madhoun@dasmaninstitute.org; fahd.almulla@dasmaninstitute.org;
   rasheed.ahmad@dasmaninstitute.org; sardar.sindhu@dasmaninstitute.org
RI Al Madhoun, Ashraf/I-3043-2012; Abu-Farha, Mohamed/KHW-8579-2024;
   Arefanian, Hossein/K-2422-2019; Ahmad, Rasheed/LMP-1937-2024; sindhu,
   sardar/ABE-3565-2021; Al-Mulla, Fahd/E-2068-2015
OI Alrashed, Fatema/0000-0003-4020-5978; Abu-Farha,
   Mohamed/0000-0001-8357-1252
FU We thank Valerie Lopez for PBMC isolation and Lubaina Koti for editorial
   assistance. The authors also thank the study participants.
FX We thank Valerie Lopez for PBMC isolation and Lubaina Koti for editorial
   assistance. The authors also thank the study participants.
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IS 20
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DI 10.3390/ijms242015186
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WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA X4BW7
UT WOS:001097933200001
PM 37894865
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Fang, CY
   Egleston, BL
   Gabriel, KP
   Stevens, VJ
   Kwiterovich, PO
   Snetselaar, LG
   Longacre, ML
   Dorgan, JF
AF Fang, Carolyn Y.
   Egleston, Brian L.
   Gabriel, Kelley Pettee
   Stevens, Victor J.
   Kwiterovich, Peter O., Jr.
   Snetselaar, Linda G.
   Longacre, Margaret L.
   Dorgan, Joanne F.
TI Depressive symptoms and serum lipid levels in young adult women
SO JOURNAL OF BEHAVIORAL MEDICINE
LA English
DT Article
DE Depression; Cholesterol; Health behaviors; Diet
ID DENSITY-LIPOPROTEIN CHOLESTEROL; ARTERY RISK DEVELOPMENT; METABOLIC
   SYNDROME; LIFE-STYLE; DIETARY INTERVENTION; PHYSICAL-ACTIVITY; HEALTH
   BEHAVIORS; POLYMORPHISM; ASSOCIATION; MEDIATION
AB Accumulating data suggest that depression is associated with risk factors for cardiovascular disease, but few studies have investigated potential behavioral mediators of such associations, particularly among women. In this study of healthy young adult women (n = 225), we examined associations among depressive symptoms, health behaviors, and serum lipid levels. Depressive symptoms were assessed with the 20-item Center for Epidemiologic Studies-Depression scale, and a fasting blood sample was obtained for serum lipid levels, including total cholesterol, high-density lipoprotein (HDL-C) and low-density lipoprotein (LDL-C). Diet was measured using 24-h recalls, and other health behaviors (physical activity, smoking) were assessed via self-report questionnaire. Results indicated a modest negative association between depressive symptoms and LDL-C levels. Higher levels of depressive symptoms were also associated with lower total and insoluble dietary fiber intake, both of which were associated with HDL-C and LDL-C. Mediational analyses indicated a significant indirect effect of depressive symptoms on LDL-C via total and insoluble dietary fiber in unadjusted analyses, but not in adjusted analyses. The present findings suggest that depressive symptoms are inversely associated with serum LDL-C levels in young adult women, but that these associations are not likely mediated by adverse lifestyle behaviors.
C1 [Fang, Carolyn Y.; Longacre, Margaret L.] Fox Chase Canc Ctr, Canc Prevent & Control Program, Philadelphia, PA 19111 USA.
   [Egleston, Brian L.] Fox Chase Canc Ctr, Dept Biostat & Bioinformat, Philadelphia, PA 19111 USA.
   [Gabriel, Kelley Pettee] Univ Texas Hlth Sci Ctr Houston, Div Epidemiol Human Genet & Environm Sci, Univ Texas Sch Publ Hlth Austin Reg Campus, Univ Texas Adm Bldg UTA, Austin, TX 78701 USA.
   [Stevens, Victor J.] Kaiser Permanente Ctr Hlth Res, Portland, OR 97227 USA.
   [Kwiterovich, Peter O., Jr.] Johns Hopkins Univ, Sch Med, Dept Pediat, Lipid Res Atherosclerosis Unit, Baltimore, MD 21287 USA.
   [Kwiterovich, Peter O., Jr.] Johns Hopkins Univ, Sch Med, Dept Med, Lipid Res Atherosclerosis Unit, Baltimore, MD 21287 USA.
   [Snetselaar, Linda G.] Univ Iowa, Coll Publ Hlth, Dept Epidemiol, Iowa City, IA 52242 USA.
   [Dorgan, Joanne F.] Fox Chase Canc Ctr, Womens Canc Program, Philadelphia, PA 19111 USA.
C3 Fox Chase Cancer Center; Fox Chase Cancer Center; University of Texas
   System; University of Texas Health Science Center Houston; Kaiser
   Permanente; Johns Hopkins University; Johns Hopkins University;
   University of Iowa; Fox Chase Cancer Center
RP Fang, CY (corresponding author), Fox Chase Canc Ctr, Canc Prevent & Control Program, Robert C Young Pavil,4th Floor,333 Cottman Ave, Philadelphia, PA 19111 USA.
EM carolyn.fang@fccc.edu; brian.egleston@fccc.edu;
   Kelley.P.Gabriel@uth.tmc.edu; victor.j.stevens@kpchr.org;
   pkwitero@jhmi.edu; linda-snetselaar@uiowa.edu;
   margaret.longacre@fccc.edu; joanne.dorgan@fccc.edu
RI Egleston, Brian/P-1000-2019; Fang, Carolyn/A-2324-2008
OI Egleston, Brian/0000-0002-1633-799X; Fang, Carolyn/0000-0002-0575-3867
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NR 60
TC 27
Z9 30
U1 0
U2 20
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0160-7715
EI 1573-3521
J9 J BEHAV MED
JI J. Behav. Med.
PD APR
PY 2013
VL 36
IS 2
BP 143
EP 152
DI 10.1007/s10865-012-9409-1
PG 10
WC Psychology, Clinical
WE Social Science Citation Index (SSCI)
SC Psychology
GA 109RG
UT WOS:000316385600004
PM 22382824
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Anderson, RE III
   Graham, KA
AF Anderson III, Robert E.
   Graham, Karen A.
TI North Carolina Healthy Active Living: Describing a Wellness Coaching
   Program for First-Episode Psychosis Clinics
SO AMERICAN JOURNAL OF LIFESTYLE MEDICINE
LA English
DT Article; Early Access
DE first-episode psychosis; coordinated specialty care; psychosis;
   lifestyle interventions
ID LIFE-STYLE INTERVENTIONS; SOCIAL COGNITIVE THEORY; INDUCED WEIGHT-GAIN;
   PHYSICAL-ACTIVITY; SEDENTARY BEHAVIOR; METABOLIC SYNDROME;
   MENTAL-ILLNESS; BLOOD-PRESSURE; OBESE ADULTS; SCHIZOPHRENIA
AB Cardiovascular disease presents a ten-fold higher risk of death than suicide in individuals with serious mental illness. Individuals experiencing first-episode psychosis already have high rates of modifiable risk factors contributing to cardiovascular disease. The initial 12 months are crucial for implementing behavioral interventions for effective risk factor modification and disease prevention. Coordinated Specialty Care (CSC) outpatient clinics provide multi-disciplinary team-based treatment for teens and young adults in the early stages of psychotic illness, significantly improving mental health outcomes and quality of life. However, these clinics lack support for addressing lifestyle behavior changes in their clients. The North Carolina Healthy Active Living (NC HeAL) program is an innovative clinical service offered to all CSC clients in this state. It offers personalized health and wellness coaching to help clients achieve meaningful health improvements. This paper provides a detailed description of the program's development, the target population and setting, the roles and skills of the NC HeAL team, program components and evidence-based program measures. Results of program measures, feasibility, acceptability, implementation, and fidelity will be published separately.
C1 [Anderson III, Robert E.] Univ North Carolina Chapel Hill, Gillings Sch Global Publ Hlth, Dept Nutr, Chapel Hill, NC USA.
   [Graham, Karen A.] Univ North Carolina Chapel Hill, Dept Psychiat, 101 Manning Dr 1, Chapel Hill, NC 27514 USA.
C3 University of North Carolina School of Medicine; University of North
   Carolina; University of North Carolina Chapel Hill; University of North
   Carolina; University of North Carolina Chapel Hill; University of North
   Carolina School of Medicine
RP Graham, KA (corresponding author), Univ North Carolina Chapel Hill, Dept Psychiat, 101 Manning Dr 1, Chapel Hill, NC 27514 USA.
EM karen_graham@med.unc.edu
OI Anderson III, Robert E./0000-0002-0008-7754
FU NC Division of MHDDSA; NC First-Episode Psychosis Coordinated Specialty
   Care (NC-CSC) Programs; Federal Community Mental Health Services Block
   Grant (CFDA) [93.958]
FX The author(s) disclosed receipt of the followingfinancialsupport for the
   research, authorship, and/or publicationof this article: Early Psychosis
   Interventions of North Carolina (EPI-NC) is funded by the NC Division of
   MHDDSA and supports NC First-Episode Psychosis Coordinated Specialty
   Care (NC-CSC) Programs.Federal Community Mental Health Services Block
   Grant(CFDA #93.958).
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NR 83
TC 0
Z9 0
U1 0
U2 0
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1559-8276
EI 1559-8284
J9 AM J LIFESTYLE MED
JI Am. J. Lifestyle Med.
PD 2025 APR 10
PY 2025
DI 10.1177/15598276251331854
EA APR 2025
PG 9
WC Public, Environmental & Occupational Health
WE Emerging Sources Citation Index (ESCI)
SC Public, Environmental & Occupational Health
GA 1FX6F
UT WOS:001464078900001
PM 40224299
DA 2025-06-11
ER

PT J
AU Mantzorou, M
   Pavlidou, E
   Vasios, G
   Tsagalioti, E
   Giaginis, C
AF Mantzorou, Maria
   Pavlidou, Eleni
   Vasios, George
   Tsagalioti, Eftychia
   Giaginis, Constantinos
TI Effects of curcumin consumption on human chronic diseases: A narrative
   review of the most recent clinical data
SO PHYTOTHERAPY RESEARCH
LA English
DT Review
DE cancer; chronic diseases; curcumin; diabetes; inflammation; metabolic
   syndrome; obesity
ID MAJOR DEPRESSIVE DISORDER; HIGHLY-BIOAVAILABLE CURCUMIN;
   INFLAMMATORY-BOWEL-DISEASE; FATTY LIVER-DISEASE; DOUBLE-BLIND; PHASE-I;
   ULCERATIVE-COLITIS; ORAL CURCUMIN; CHEMOPREVENTIVE AGENT; KNEE
   OSTEOARTHRITIS
AB Numerous clinical trials have investigated the potential beneficial effects of curcumin supplementation against several human chronic diseases. Up to now, it has been claimed that curcumin consumption may exert beneficial effects against several chronic diseases by promoting human health and preventing diseases. In this aspect, the present review aims to critically collect and in-depth summarize the most recent, well-designed clinical studies evaluating the potential beneficial effects of curcumin consumption on human health promotion and disease prevention. According to recent and well-designed clinical studies, curcumin consumption may benefit against obesity, metabolic syndrome, and diabetes. Moreover, curcumin consumption seems to exert a positive effect on people suffering from various types of cancer, fatty liver disease, depression, arthritis, skin diseases, gut inflammation, and symptoms of premenstrual syndrome. Due to the strong heterogeneity among the clinical studies concerning the exact effective curcumin dose and formulation, as well as the recommended treatment duration for each chronic disease, no precise and definitive conclusions could be drawn. Further large-scale prospective studies are strongly recommended, being well-designed as far as follow-up times, dosage, formulation, and duration of curcumin supplementation are concerned. Moreover, potential confounders in each specific chronic disease should carefully be taken into account in future studies.
C1 [Mantzorou, Maria; Pavlidou, Eleni; Vasios, George; Tsagalioti, Eftychia; Giaginis, Constantinos] Univ Aegean, Sch Environm, Dept Food Sci & Nutr, Myrina, Lemnos, Greece.
RP Mantzorou, M (corresponding author), Univ Aegean, Dept Food Sci & Nutr, Mitropoliti Ioakim 2, Myrina 81440, Lemnos, Greece.
EM mantzorou.m@aegean.gr
RI Giaginis, Constantinos/JMQ-9552-2023; Pavlidou, Eleni/JMB-5502-2023
OI Pavlidou, Eleni/0000-0002-7764-3544; Mantzorou,
   Maria/0000-0002-2535-2841; Giaginis, Constantinos/0000-0003-2878-4831
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NR 86
TC 100
Z9 108
U1 0
U2 62
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0951-418X
EI 1099-1573
J9 PHYTOTHER RES
JI Phytother. Res.
PD JUN
PY 2018
VL 32
IS 6
BP 957
EP 975
DI 10.1002/ptr.6037
PG 19
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA GI4TL
UT WOS:000434364000001
PM 29468820
DA 2025-06-11
ER

PT J
AU Bhasin, S
   Enzlin, P
   Coviello, A
   Basson, R
AF Bhasin, Shalender
   Enzlin, Paul
   Coviello, Andrea
   Basson, Rosemary
TI Sexual dysfunction 3 - Sexual dysfunction in men and women with
   endocrine disorders
SO LANCET
LA English
DT Review
ID QUALITY-OF-LIFE; SURGICALLY MENOPAUSAL WOMEN; TESTOSTERONE REPLACEMENT
   THERAPY; CONGENITAL ADRENAL-HYPERPLASIA; BENIGN PROSTATIC HYPERPLASIA;
   POLYCYSTIC-OVARY-SYNDROME; ERECTILE DYSFUNCTION; METABOLIC SYNDROME;
   ANDROGEN LEVELS; DESIRE DISORDER
AB Endocrine disease frequently interrupts sexual function, and sexual dysfunction may signal serious endocrine disease. Diabetic autonomic neuropathy and endothelial dysfunction impair erectile function, and phosphodiesterase inhibition produces only moderate benefit. The effect of diabetes on women's sexual function is complex: the most consistent finding is a correlation between sexual dysfunction and depression. Reductions in testosterone level in men are associated with low sexual desire and reduced nocturnal erections and ejaculate volume, all of which improve with testosterone supplementation. The age-dependent decline in testosterone production in men is not associated with precise sexual symptoms, and supplementation has not been shown to produce sexual benefit. In women, sexual dysfunction has not been associated with serum testosterone, but this may be confounded by limitations of assays at low concentrations and by the greater importance of intracellular production of testosterone in women than in men. Testosterone supplementation after menopause does improve some aspects of sexual function in women, but long-term outcome data are needed. More research on the sexual effects of abnormal adrenal and thyroid function, hyperprolactinaemia, and metabolic syndrome should also be prioritised. We have good data on local management of the genital consequences of oestrogen lack, but need to better understand the potential role of systemic oestrogen supplementation from menopause onwards in sexually symptomatic women.
C1 Boston Univ, Sch Med, Boston Med Ctr, Sect Endocrinol Diabet & Nutr, Boston, MA 02199 USA.
   Catholic Univ Louvain, Inst Family & Sexuality Studies, B-3000 Louvain, Belgium.
   Univ Hosp Gasthuisberg, Dept Psychiat, B-3000 Louvain, Belgium.
   Univ Hosp Gasthuisberg, Dept Gynaecol, B-3000 Louvain, Belgium.
   Univ British Columbia, Dept Psychiat, Vancouver, BC V5Z 1M9, Canada.
   Univ British Columbia, Dept Obstet & Gynecol, Vancouver, BC V5Z 1M9, Canada.
   Univ British Columbia, BC Ctr Sexual Med, Vancouver, BC V5Z 1M9, Canada.
   Univ British Columbia, Vancouver Gen Hosp, Vancouver, BC V5Z 1M9, Canada.
C3 Boston Medical Center; Boston University; Universite Catholique Louvain;
   KU Leuven; University Hospital Leuven; KU Leuven; University Hospital
   Leuven; University of British Columbia; University of British Columbia;
   University of British Columbia; University of British Columbia
RP Bhasin, S (corresponding author), Boston Univ, Sch Med, Boston Med Ctr, Sect Endocrinol Diabet & Nutr, Boston, MA 02199 USA.
EM bhasin@bu.edu
RI Enzlin, Paul/AAW-3160-2020
OI Enzlin, Paul/0000-0002-6641-5159; Coviello, Andrea/0000-0003-0244-9787
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NR 169
TC 208
Z9 215
U1 0
U2 23
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0140-6736
EI 1474-547X
J9 LANCET
JI Lancet
PD FEB 17
PY 2007
VL 369
IS 9561
BP 597
EP 611
DI 10.1016/S0140-6736(07)60280-3
PG 15
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA 138MZ
UT WOS:000244368000034
PM 17307107
DA 2025-06-11
ER

PT J
AU Aljahdali, AA
   Shi, ZM
AF Aljahdali, Abeer Ali
   Shi, Zumin
TI Circadian Syndrome Is Associated with Dietary Patterns among
   Middle-Older Americans: The Health and Retirement Study
SO NUTRIENTS
LA English
DT Article
DE diet; dietary patterns; circadian rhythms; circadian syndrome; Health
   and Retirement Study; middle-older adults; US
ID ALL-CAUSE MORTALITY; METABOLIC SYNDROME; CARDIOVASCULAR-DISEASE; RISK;
   RHYTHMS; METAANALYSIS; GLUCOSE; CLOCKS; COHORT; SYSTEM
AB Population aging is a global demographic characteristic of the 21st century, and healthy eating is a core component of healthy aging. However, limited evidence is available among older adults for associations between diet quality and circadian syndrome (CircS). Thus, this study examined associations between dietary patterns and CircS among a representative sample of middle-older adults in the US. The sample comprised middle-older adults enrolled in the 2016 core wave of the Health and Retirement Study (HRS) and one of its sub-studies, the 2013 Health Care and Nutrition Study (HCNS). A food frequency questionnaire was used to quantify habitual food intake and identify dietary patterns using a factor analysis. CircS was defined based on the existence of >= 4 components of metabolic syndrome and indicators of sleep disorders and depression. A total of 4253 middle-older adults with a mean age (SD) of 65.4 (10.0) years were included in the study. The prevalence of CircS was 35.9%. Comparing extreme quartiles of the "Prudent Pattern", the odds ratio (95% CI) for CircS was 0.72 (0.55-0.94), and it was 1.47 (1.10-1.95) for the "Western Pattern". The "Western Pattern" was positively associated while the "Prudent Pattern" was inversely associated with the odds of CircS among middle-older adults.
C1 [Aljahdali, Abeer Ali] King Abdulaziz Univ, Fac Appl Med Sci, Dept Clin Nutr, Jeddah 21589, Saudi Arabia.
   [Aljahdali, Abeer Ali] Univ Michigan, Dept Nutr Sci, Ann Arbor, MI 48109 USA.
   [Shi, Zumin] Qatar Univ, QU Hlth, Coll Hlth Sci, Human Nutr Dept, POB 2713, Doha, Qatar.
C3 King Abdulaziz University; University of Michigan System; University of
   Michigan; Qatar University
RP Shi, ZM (corresponding author), Qatar Univ, QU Hlth, Coll Hlth Sci, Human Nutr Dept, POB 2713, Doha, Qatar.
EM aaoaljahdali1@kau.edu.sa; zumin@qu.edu.qa
RI Shi, Zumin/A-1093-2009; Aljahdali, Abeer/AFP-2790-2022
OI Shi, Zumin/0000-0002-3099-3299; Aljahdali, Abeer/0000-0003-3104-1019
FU National Institute of Aging
FX No Statement Available
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NR 68
TC 1
Z9 2
U1 5
U2 13
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD MAR
PY 2024
VL 16
IS 6
AR 760
DI 10.3390/nu16060760
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA MI0M4
UT WOS:001192876400001
PM 38542672
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Smolarczyk, K
   Meczekalski, B
   Rudnicka, E
   Suchta, K
   Szeliga, A
AF Smolarczyk, Katarzyna
   Meczekalski, Blazej
   Rudnicka, Ewa
   Suchta, Katarzyna
   Szeliga, Anna
TI Association of Obesity and Bariatric Surgery on Hair Health
SO MEDICINA-LITHUANIA
LA English
DT Review
DE obesity; hair loss; bariatric surgery
ID ONSET ANDROGENETIC ALOPECIA; METABOLIC SYNDROME; INSULIN-RESISTANCE;
   RISK-FACTORS; WOMEN; MEN; ADIPOKINES; SOCIETY; LEPTIN
AB Obesity and obesity-related conditions today constitute a public health problem worldwide. Obesity is an "epidemic" chronic disorder, which is defined by the WHO as normal or excessive fat accumulation that may impair health. It is also defined for adults as a BMI that is greater than or equal to 30. The most common obesity-related diseases are type 2 diabetes mellitus, cardiovascular diseases, metabolic syndrome, chronic kidney disease, hyperlipidemia, hypertension, nonalcoholic fatty liver disease, and certain types of cancer. It has been also proven that obesity can have a negative effect on hair. It can lead to hair thinning. Patients with obesity can undergo bariatric surgery if they meet the inclusion criteria. The four common types of weight loss surgery include a duodenal switch with biliopancreatic diversion, laparoscopic adjustable gastric banding, Roux-en-Y gastric bypass, and sleeve gastrectomy. Bariatric surgery can affect skin and hair and is associated with telogen effluvium due to weight loss, microelement deficiency, anesthesia, low calorie intake, and low protein intake. Patients who undergo bariatric surgery can experience post-bariatric surgery depression. Hair loss can have a major impact on self-esteem, negatively affecting one's self-image. The purpose of this narrative review is to critically review how obesity, obesity-related diseases, and bariatric surgery affect hair health in general and the hair development cycle, and how they influence hair loss.
C1 [Smolarczyk, Katarzyna] Med Univ Warsaw, Dept Dermatol, PL-02008 Warsaw, Poland.
   [Meczekalski, Blazej; Szeliga, Anna] Poznan Univ Med Sci, Dept Gynecol Endocrinol, PL-60535 Poznan, Poland.
   [Rudnicka, Ewa; Suchta, Katarzyna] Warsaw Med Univ, Dept Gynecol Endocrinol, PL-00315 Warsaw, Poland.
C3 Medical University of Warsaw; Poznan University of Medical Sciences;
   Medical University of Warsaw
RP Smolarczyk, K (corresponding author), Med Univ Warsaw, Dept Dermatol, PL-02008 Warsaw, Poland.
EM ksmolarczyk@gmail.com; blazejmeczekalski@yahoo.com;
   ewa.rudnicka@poczta.onet.pl; suchta.katarzyna@gmail.com;
   annamaria.szeliga@gmail.com
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NR 67
TC 5
Z9 5
U1 2
U2 6
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1010-660X
EI 1648-9144
J9 MEDICINA-LITHUANIA
JI Med. Lith.
PD FEB
PY 2024
VL 60
IS 2
AR 325
DI 10.3390/medicina60020325
PG 12
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA JI8C5
UT WOS:001172617800001
PM 38399612
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Ahuja, S
   Caldwell, JD
   Shanks, BC
   Flores, R
AF Ahuja, Suman
   Caldwell, James D.
   Shanks, Bruce C.
   Flores, Rene
TI Effects of macronutrient composition and meal frequency on cortisol
   levels in humans
SO AGRO FOOD INDUSTRY HI-TECH
LA English
DT Article
ID PSYCHOSOCIAL STRESS; HEALTHY-SUBJECTS; PLASMA-CORTISOL; PROTEIN; FAT;
   SECRETION; DIET; BEHAVIOR; OBESITY; WEIGHT
AB Obesity has reached epidemic proportions world-wide with approximately 1.6 billion adults overweight (Body Mass Index (BMI) >= 25kg/m(2)), almost 400 million clinically obese (BMI >= 30kg/m(2)), and an estimated 2.3 billion people will be overweight by the year 2015 (1). Obesity is a major risk factor for several chronic diseases and is a multi-factorial disorder that includes many contributing factors such as quality and quantity of food consumption, physical activity, hormonal imbalance, and life style choices. Of these, new attention has been given to certain hormones elevated by macronutrients and their relationship with other disorders. There has been speculation that moderate increase in cortisol levels may lead to an increased risk for cardiovascular disease, glucose intolerance, hypertension, and dyslipidemia, all classic conditions associated with metabolic syndrome (2). In fact, it has been reported that exposure to elevated maternal cortisol levels may have a negative impact on the fetus, which may result in predisposition to high blood pressure, elevated basal stress-induced glucocorticoid, and other features of metabolic syndrome in later adult life (3). Of the many contributing factors of obesity, it appears that macronutrient composition and frequency of meal consumption might be two important pieces of this puzzle. Both, meal composition and frequency have shown to impact various hormones, particularly those related to obesity, diabetes, and CVD. Therefore, we propose to review effects of macronutrient composition and meal frequency on cortisol levels in humans.
C1 [Flores, Rene] Univ Texas Hlth Sci Ctr Houston, Ctr Nursing Res, Houston, TX 77030 USA.
   [Ahuja, Suman; Caldwell, James D.; Shanks, Bruce C.] Lincoln Univ, Dept Agr & Environm Sci, Jefferson City, MO 65101 USA.
C3 University of Texas System; University of Texas Health Science Center
   Houston; Lincoln University - Missouri
RP Flores, R (corresponding author), Univ Texas Hlth Sci Ctr Houston, Ctr Nursing Res, 6901 Bertner Ave, Houston, TX 77030 USA.
RI Martínez Flores, René/GLT-6329-2022
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NR 22
TC 0
Z9 0
U1 0
U2 6
PU TEKNOSCIENZE PUBL
PI MILANO
PA VIALE BRIANZA 22, 20127 MILANO, ITALY
SN 1722-6996
J9 AGRO FOOD IND HI TEC
JI Agro Food Ind. Hi-Tech
PD MAR-APR
PY 2012
VL 23
IS 2
SU S
BP 4
EP 5
PG 2
WC Biotechnology & Applied Microbiology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Food Science & Technology
GA 953CS
UT WOS:000304845100002
DA 2025-06-11
ER

PT J
AU Soda, T
   Pasqua, T
   De Sarro, G
   Moccia, F
AF Soda, Teresa
   Pasqua, Teresa
   De Sarro, Giovambattista
   Moccia, Francesco
TI Cognitive Impairment and Synaptic Dysfunction in Cardiovascular
   Disorders: The New Frontiers of the Heart-Brain Axis
SO BIOMEDICINES
LA English
DT Review
DE heart-brain axis; cardiovascular disorders; synaptic plasticity;
   cardiogenic dementia; cognitive impairment; heart failure; metabolic
   syndrome; arrhythmias; NMDA receptors; long-term potentiation
ID LONG-TERM POTENTIATION; METABOTROPIC GLUTAMATE RECEPTORS;
   STREPTOZOTOCIN-DIABETIC RATS; TIMING-DEPENDENT PLASTICITY;
   ANGIOTENSIN-II; AMPA RECEPTORS; ANIMAL-MODEL; INTRACEREBROVENTRICULAR
   INJECTION; HIPPOCAMPAL GLUTAMATE; INSULIN-RESISTANCE
AB Within the central nervous system, synaptic plasticity, fundamental to processes like learning and memory, is largely driven by activity-dependent changes in synaptic strength. This plasticity often manifests as long-term potentiation (LTP) and long-term depression (LTD), which are bidirectional modulations of synaptic efficacy. Strong epidemiological and experimental evidence show that the heart-brain axis could be severely compromised by both neurological and cardiovascular disorders. Particularly, cardiovascular disorders, such as heart failure, hypertension, obesity, diabetes and insulin resistance, and arrhythmias, may lead to cognitive impairment, a condition known as cardiogenic dementia. Herein, we review the available knowledge on the synaptic and molecular mechanisms by which cardiogenic dementia may arise and describe how LTP and/or LTD induction and maintenance may be compromised in the CA1 region of the hippocampus by heart failure, metabolic syndrome, and arrhythmias. We also discuss the emerging evidence that endothelial dysfunction may contribute to directly altering hippocampal LTP by impairing the synaptically induced activation of the endothelial nitric oxide synthase. A better understanding of how CV disorders impact on the proper function of central synapses will shed novel light on the molecular underpinnings of cardiogenic dementia, thereby providing a new perspective for more specific pharmacological treatments.
C1 [Soda, Teresa; Pasqua, Teresa; De Sarro, Giovambattista] Magna Graecia Univ Catanzaro, Dept Hlth Sci, I-88100 Catanzaro, Italy.
   [Moccia, Francesco] Univ Molise, Dept Med & Hlth Sci V Tiberio, I-86100 Campobasso, Italy.
C3 Magna Graecia University of Catanzaro; University of Molise
RP Soda, T (corresponding author), Magna Graecia Univ Catanzaro, Dept Hlth Sci, I-88100 Catanzaro, Italy.
EM teresa.soda@unicz.it; teresa.pasqua@unicz.it; desarro@unicz.it;
   francesco.moccia@unimol.it
RI De Sarro, Giovambattista/G-5256-2010; Moccia, Francesco/AAX-6447-2020;
   Soda, Teresa/HNS-4686-2023
OI Moccia, Francesco/0000-0003-0010-0098; Soda, Teresa/0000-0002-7728-6815;
   De Sarro, Giovambattista/0000-0002-7629-6579
FU #NEXTGENERATIONEU (NGEU); Ministry of University and Research (MUR)
   [PE0000006, 1553 11.10.2022]; National Recovery and Resilience Plan
   (NRRP); European Commission's FESR FSE
FX This research has been supported by #NEXTGENERATIONEU (NGEU) and funded
   by the Ministry of University and Research (MUR), National Recovery and
   Resilience Plan (NRRP), project MNESYS (PE0000006)-A Multiscale
   integrated approach to the study of the nervous system in health and
   disease (DN. 1553 11.10.2022) (G.D.S. and F.M.) and European
   Commission's FESR FSE 2014-2020 and POR CALABRIA FESR AZIONE 1.5.1
   "Support for research infrastructures considered critical/crucial for
   regional systems" Nuova Piattaforma di Farmacologia Integrata e
   Tecnologie Avanzate (G.D.S.).
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NR 271
TC 2
Z9 2
U1 11
U2 12
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2227-9059
J9 BIOMEDICINES
JI Biomedicines
PD OCT
PY 2024
VL 12
IS 10
AR 2387
DI 10.3390/biomedicines12102387
PG 24
WC Biochemistry & Molecular Biology; Medicine, Research & Experimental;
   Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Research & Experimental Medicine;
   Pharmacology & Pharmacy
GA K3M1Q
UT WOS:001342941600001
PM 39457698
OA gold
DA 2025-06-11
ER

PT J
AU Grillo, CA
   Mulder, P
   Macht, VA
   Kaigler, KF
   Wilson, SP
   Wilson, MA
   Reagan, LP
AF Grillo, Claudia A.
   Mulder, Petra
   Macht, Victoria A.
   Kaigler, Kris F.
   Wilson, Steven P.
   Wilson, Marlene A.
   Reagan, Lawrence P.
TI Dietary restriction reverses obesity-induced anhedonia
SO PHYSIOLOGY & BEHAVIOR
LA English
DT Article
DE Leptin; Triglycerides; Pro-inflammatory cytokines; Metabolic syndrome;
   Depressive illness
ID INSULIN-RECEPTOR EXPRESSION; GASTRIC BYPASS-SURGERY; C-REACTIVE PROTEIN;
   QUALITY-OF-LIFE; DEPRESSIVE SYMPTOMS; RANDOMIZED-TRIAL; DOWN-REGULATION;
   MOOD DISORDERS; YOUNG FINNS; WEIGHT-LOSS
AB Obesity-induced changes in the metabolic and endocrine milieu elicit deficits in neuroplasticity, including increased risk for development of neuropsychiatric disorders such as depressive illness. We previously demonstrated that downregulation of hypothalamic insulin receptors (hypo-IRAS) elicits a phenotype that is consistent with features of the metabolic syndrome (MetS) and that rats with this phenotype exhibit deficits in neuronal plasticity, including depressive-like behaviors such as anhedonia. Since food restriction paradigms effectively inhibit obesity-induced neuroplasticity deficits, the aim of the current study was to determine whether food restriction could reverse obesity-induced anhedonia in hypo-IRAS rats. Compared to hypo-IRAS rats provided ad lib food access, food restriction paradigms that were initiated either prior to increases in body weight or following development of the MetS/obesity phenotype effectively restored sucrose intake in hypo-IRAS rats. Moreover, food restriction paradigms were able to prevent and reverse the changes in the endocrine/metabolic/inflammatory milieu observed in hypo-IRAS, such as increases in plasma leptin and triglyceride levels and increases in pro-inflammatory cytokines such as IL-1 alpha, IL-6 and C-reactive protein (CRP). Collectively, these results demonstrate that obesity-induced anhedonia is a reversible process and identify some potential mechanistic mediators that may be responsible for co-morbid depression in obesity. Published by Elsevier Inc.
C1 [Grillo, Claudia A.; Mulder, Petra; Macht, Victoria A.; Kaigler, Kris F.; Wilson, Steven P.; Wilson, Marlene A.; Reagan, Lawrence P.] Univ S Carolina, Sch Med, Dept Pharmacol Physiol & Neurosci, Columbia, SC 29208 USA.
   [Wilson, Marlene A.; Reagan, Lawrence P.] WJB Dorn Vet Affairs Med Ctr, Columbia, SC USA.
C3 University of South Carolina System; University of South Carolina
   Columbia
RP Reagan, LP (corresponding author), Univ S Carolina, Sch Med, Dept Pharmacol Physiol & Neurosci, 6439 Garners Ferry Rd,Room D40, Columbia, SC 29208 USA.
EM lpreagan@uscmed.sc.edu
RI A Wilson, Marlene/JRW-2264-2023; Grillo, Claudia/J-6373-2012
OI Grillo, Claudia/0000-0001-9599-7234; Wilson,
   Marlene/0000-0003-4770-9669; Mulder, Petra/0000-0002-0982-4466
FU Department of Veterans Affairs [IO1 BX001804-01]; National Institutes of
   Health [R01 MH063344]; University of South Carolina Research Foundation
FX This work was supported by the Department of Veterans Affairs (IO1
   BX001804-01; LPR), the National Institutes of Health (R01 MH063344; MAW)
   and the University of South Carolina Research Foundation.
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NR 46
TC 25
Z9 27
U1 3
U2 13
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0031-9384
J9 PHYSIOL BEHAV
JI Physiol. Behav.
PD APR 10
PY 2014
VL 128
BP 126
EP 132
DI 10.1016/j.physbeh.2014.01.026
PG 7
WC Psychology, Biological; Behavioral Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Behavioral Sciences
GA AG0LE
UT WOS:000335106200019
PM 24518861
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Cardinali, DP
   Brown, GM
   Pandi-Perumal, SR
AF Cardinali, Daniel P.
   Brown, Gregory M.
   Pandi-Perumal, Seithikurippu R.
TI Can Melatonin Be a Potential "Silver Bullet" in Treating COVID-19
   Patients?
SO DISEASES
LA English
DT Review
DE aging; anti-SARS-CoV-2 vaccination; chronotherapy; COVID-19 pandemic;
   cytoprotection; diabetes; inflammation; metabolic syndrome; melatonin;
   cognitive impairment; neurodegeneration; oxidative stress;
   renin-angiotensin system
ID RENIN-ANGIOTENSIN SYSTEM; SLEEP DISTURBANCES; OXIDATIVE STRESS;
   INHIBITION; EXPRESSION; MOLECULE; DELIRIUM; DISEASE; CANCER; CELLS
AB The therapeutic potential of melatonin as a chronobiotic cytoprotective agent to counteract the consequences of COVID-19 infections has been advocated. Because of its wide-ranging effects as an antioxidant, anti-inflammatory, and immunomodulatory compound, melatonin could be unique in impairing the consequences of SARS-CoV-2 infection. Moreover, indirect evidence points out to a possible antiviral action of melatonin by interfering with SARS-CoV-2/angiotensin-converting enzyme 2 association. Melatonin is also an effective chronobiotic agent to reverse the circadian disruption of social isolation and to control delirium in severely affected patients. As a cytoprotector, melatonin serves to combat several comorbidities such as diabetes, metabolic syndrome, and ischemic and non-ischemic cardiovascular diseases, which aggravate COVID-19 disease. In view of evidence on the occurrence of neurological sequels in COVID-19-infected patients, another putative application of melatonin emerges based on its neuroprotective properties. Since melatonin is an effective means to control cognitive decay in minimal cognitive impairment, its therapeutic significance for the neurological sequels of SARS-CoV-2 infection should be considered. Finally, yet importantly, exogenous melatonin can be an adjuvant capable of augmenting the efficacy of anti-SARS-CoV-2 vaccines. We discuss in this review the experimental evidence suggesting that melatonin is a potential "silver bullet" in the COVID 19 pandemic.
C1 [Cardinali, Daniel P.] Pontificia Univ Catolica Argentina, Fac Med Sci, RA-1007 Buenos Aires, DF, Argentina.
   [Brown, Gregory M.] Univ Toronto, Dept Psychiat, Ctr Addict & Mental Hlth, Toronto, ON M5T 1R8, Canada.
   [Pandi-Perumal, Seithikurippu R.] Somnogen Canada Inc, Coll St, Toronto, ON M6H 1C5, Canada.
C3 Pontificia Universidad Catolica Argentina; University of Toronto; Centre
   for Addiction & Mental Health - Canada
RP Pandi-Perumal, SR (corresponding author), Somnogen Canada Inc, Coll St, Toronto, ON M6H 1C5, Canada.
EM daniel_cardinali@uca.edu.ar; gregory.brown@camh.ca;
   Pandiperumal2020@gmail.com
RI Pandi-Perumal, Seithikurippu/Q-8281-2016; Brown, Gregory/ACV-1983-2022;
   Pandi-Perumal, Seithikurippu R/C-6767-2008
OI Pandi-Perumal, Seithikurippu R/0000-0002-8686-7259
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NR 119
TC 53
Z9 53
U1 0
U2 2
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2079-9721
J9 DISEASES-BASEL
JI Diseases
PD DEC
PY 2020
VL 8
IS 4
AR 44
DI 10.3390/diseases8040044
PG 15
WC Medicine, Research & Experimental
WE Emerging Sources Citation Index (ESCI)
SC Research & Experimental Medicine
GA TY8FI
UT WOS:000684014900009
PM 33256258
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Limberg, JK
   Harrell, JW
   Johansson, RE
   Eldridge, MW
   Proctor, LT
   Sebranek, JJ
   Schrage, WG
AF Limberg, Jacqueline K.
   Harrell, John W.
   Johansson, Rebecca E.
   Eldridge, Marlowe W.
   Proctor, Lester T.
   Sebranek, Joshua J.
   Schrage, William G.
TI Microvascular function in younger adults with obesity and metabolic
   syndrome: role of oxidative stress
SO AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
LA English
DT Article
DE endothelial function; blood flow; prediabetes; nitric oxide;
   prostacyclin
ID HIGH-SALT DIET; ENDOTHELIAL DYSFUNCTION; NITRIC-OXIDE; SKELETAL-MUSCLE;
   ASCORBIC-ACID; ZUCKER RATS; MEDIATED VASODILATION; EXERCISE HYPEREMIA;
   INSULIN-RESISTANCE; HABITUAL EXERCISE
AB Older adults with cardiovascular disease exhibit microvascular dysfunction and increased levels of reactive oxygen species (ROS). We hypothesized that microvascular impairments begin early in the disease process and can be improved by scavenging ROS. Forearm blood flow (Doppler ultrasound) was measured in 45 young (32 +/- 2 yr old) adults (n = 15/group) classified as lean, obese, and metabolic syndrome (MetSyn). Vasodilation in response to endothelial (ACh) and vascular smooth muscle [nitroprusside (NTP) and epoprostenol (Epo)] agonists was tested before and after intra-arterial infusion of ascorbic acid to scavenge ROS. Vasodilation was assessed as a rise in relative vascular conductance (ml.min(-1).dl(-1).100 mmHg(-1)). ACh and NTP responses were preserved (P = 0.825 and P = 0.924, respectively), whereas Epo responses were lower in obese and MetSyn adults (P < 0.05) than in lean controls. Scavenging of ROS via infusion of ascorbic acid resulted in an increase in ACh-mediated (P < 0.001) and NTP-mediated (P < 0.001) relative vascular conductance across all groups, suggesting that oxidative stress influences vascular responsiveness in adults with and without overt cardiovascular disease risk. Ascorbic acid had no effect on Epo-mediated vasodilation (P = 0.267). These results suggest that obese and MetSyn adults exhibit preserved endothelium-dependent vasodilation with reduced dependence on prostacyclin and are consistent with an upregulation of compensatory vascular control mechanisms.
C1 [Limberg, Jacqueline K.; Harrell, John W.; Johansson, Rebecca E.; Eldridge, Marlowe W.; Schrage, William G.] Univ Wisconsin, Dept Kinesiol, Sch Educ, Madison, WI 53706 USA.
   [Eldridge, Marlowe W.] Univ Wisconsin, Sch Med & Publ Hlth, Dept Populat Hlth Sci, John Rankin Lab Pulm Med, Madison, WI 53706 USA.
   [Eldridge, Marlowe W.] Univ Wisconsin Hosp & Clin, Dept Pediat, Madison, WI 53792 USA.
   [Proctor, Lester T.; Sebranek, Joshua J.] Univ Wisconsin Hosp & Clin, Dept Anesthesiol, Madison, WI 53792 USA.
C3 University of Wisconsin System; University of Wisconsin Madison;
   University of Wisconsin System; University of Wisconsin Madison;
   University of Wisconsin System; University of Wisconsin Madison;
   University Wisconsin Madison Hospital; University of Wisconsin System;
   University of Wisconsin Madison; University Wisconsin Madison Hospital
RP Schrage, WG (corresponding author), Univ Wisconsin, Dept Kinesiol, 1149A Natatorium, Madison, WI 53706 USA.
EM wschrage@education.wisc.edu
OI Johansson, Rebecca/0000-0002-0605-1293
FU American Heart Association [10PRE3870000, 11PRE7390038]; National Heart,
   Lung, and Blood Institute [HL-091397, HL-105820]; National Institutes of
   Health [RR-000167]; American Heart Association (AHA) [10PRE3870000,
   11PRE7390038] Funding Source: American Heart Association (AHA)
FX This study was supported by American Heart Association Predoctoral
   Awards 10PRE3870000 (J. K. Limberg) and 11PRE7390038 (J. W. Harrell) and
   National Heart, Lung, and Blood Institute Grants HL-091397 and HL-105820
   (W. G. Schrage). In addition, we acknowledge the involvement of
   Wisconsin National Primate Research Center Assay Services and the
   partial support of National Institutes of Health Grant RR-000167.
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NR 46
TC 33
Z9 35
U1 0
U2 13
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0363-6135
EI 1522-1539
J9 AM J PHYSIOL-HEART C
JI Am. J. Physiol.-Heart Circul. Physiol.
PD OCT
PY 2013
VL 305
IS 8
BP H1230
EP H1237
DI 10.1152/ajpheart.00291.2013
PG 8
WC Cardiac & Cardiovascular Systems; Physiology; Peripheral Vascular
   Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Physiology
GA 237KM
UT WOS:000325868600013
PM 23934859
OA Green Published
DA 2025-06-11
ER

PT J
AU Sengul, C
   Cevik, C
   Ozveren, O
   Duman, D
   Eroglu, E
   Oduncu, V
   Tanboga, HI
   Can, MM
   Akgun, T
   Dindar, I
AF Sengul, Cihan
   Cevik, Cihan
   Ozveren, Olcay
   Duman, Dursun
   Eroglu, Elif
   Oduncu, Vecih
   Tanboga, Halil Ibrahim
   Can, Mehmet Mustafa
   Akgun, Taylan
   Dindar, Ismet
TI Epicardial Fat Thickness Is Associated with Non-Dipper Blood Pressure
   Pattern in Patients with Essential Hypertension
SO CLINICAL AND EXPERIMENTAL HYPERTENSION
LA English
DT Article
DE epicardial fat; visceral adiposity; hypertension; echocardiography;
   non-dipper
ID LEFT-VENTRICULAR HYPERTROPHY; AUTONOMIC NERVOUS-SYSTEM; TARGET ORGAN
   DAMAGE; INSULIN-RESISTANCE; ADIPOSE-TISSUE; METABOLIC SYNDROME;
   NOCTURNAL FALL; ECHOCARDIOGRAPHY; ADIPONECTIN; SOCIETY
AB Objective. Epicardial fat tissue reflects visceral adiposity and is a suggested cardiometabolic risk factor. Patients with abdominal obesity have an increased prevalence of the non-dipper blood pressure (BP) pattern, but it is unclear whether the same is true of patients with increased epicardial fat thickness (EFT). The association between EFT and circadian BP changes in patients with recently diagnosed essential hypertension was examined. Methods. Sixty hypertensive patients underwent echocardiography, treadmill stress testing, and 24 hours of ambulatory BP monitoring. Epicardial fat thickness and left ventricular mass (LVM) index were measured by using transthoracic echocardiography. The patients were categorized into two groups according to their BP pattern (group 1, non-dippers; group 2, dippers). Results. The mean EFT and LVM of patients in group 1 (n = 24) (EFT, 7.6 +/- 2.1 mm; LVM, 130 +/- 31.2 g/m(2)) were significantly greater than those of group 2 (n = 36) (EFT, 5.5 +/- 1.2 mm, P = .0001; LVM, 107 +/- 23.7 g/m(2), P = .002). The average systolic BP over 24 hours (BPs 24) and average diastolic BP over 24 hours (BPd 24) of group 1 (BPs 24, 151.1 +/- 17.6 mm Hg; BPd 24, 94.1 +/- 16.5 mm Hg) were significantly higher than those of group 2 (BPs 24, 136.7 +/- 11.9 mm Hg, P = .0001; BPd 24, 84.6 +/- 10.6 mm Hg; P = .008). Multivariate backward logistic regression analysis demonstrated that the non-dipper BP pattern was associated with EFT (standardized beta coefficient = 0.87, P = .005) and LVM (standardized beta coefficient = 0.43, P = .016). An EFT = 7 mm was associated with the non-dipper BP pattern with 44% sensitivity and 94% specificity (receiver operating characteristic area under curve of 0.72, 95% CI [0.59-0.83], P = .0007). Conclusions. Epicardial fat thickness was above average in newly diagnosed, untreated hypertensive patients with non-dipper BP pattern. The echocardiographic measurement of EFT may be used to indicate increased risk of hypertension-related adverse cardiovascular events.
C1 [Cevik, Cihan] St Lukes Episcopal Hosp, Texas Heart Inst, Div Adult Cardiol, Houston, TX 77030 USA.
   [Sengul, Cihan; Dindar, Ismet] Goztepe Med Pk Hosp, Div Cardiol, Istanbul, Turkey.
   [Ozveren, Olcay; Eroglu, Elif; Oduncu, Vecih; Tanboga, Halil Ibrahim; Can, Mehmet Mustafa; Akgun, Taylan] Kartal Kosuyolu Heart & Res Hosp, Div Cardiol, Istanbul, Turkey.
   [Duman, Dursun] Haydarpasa Numune Training & Res Hosp, Div Cardiol, Istanbul, Turkey.
C3 Texas Heart Institute; Saint Lukes Episcopal Hospital; Medical Park
   Hospitals Group; Istanbul Kartal Kosuyolu Yuksek Ihtisas Training &
   Research Hospital; Istanbul Haydarpasa Numune Training & Research
   Hospital; Istanbul Haydarpasa Sultan Abdulhamid Training & Research
   Hospital
RP Cevik, C (corresponding author), St Lukes Episcopal Hosp, Texas Heart Inst, Div Adult Cardiol, Houston, TX 77030 USA.
EM ccevik@sleh.com
RI Tanboga, Ibrahim/E-8886-2010; Eroglu, Elif/T-7450-2017; Duman,
   Dursun/B-5558-2015; AKGUN, Taylan/ABH-8172-2020
OI Tanboga, Ibrahim Halil/0000-0003-4546-9227; AKGUN,
   Taylan/0000-0002-5395-2027; ODUNCU, Vecih/0000-0001-8221-9230
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NR 40
TC 34
Z9 39
U1 0
U2 4
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1064-1963
EI 1525-6006
J9 CLIN EXP HYPERTENS
JI Clin. Exp. Hypertens.
PY 2012
VL 34
IS 3
BP 165
EP 170
DI 10.3109/10641963.2011.577488
PG 6
WC Pharmacology & Pharmacy; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Cardiovascular System & Cardiology
GA 925IF
UT WOS:000302754200002
PM 22008026
DA 2025-06-11
ER

PT J
AU Sestito, A
   Lanza, GA
   Le Pera, D
   De Armas, L
   Sgueglia, GA
   Infusino, F
   Millucci, R
   Tonali, PA
   Crea, F
   Valeriarni, M
AF Sestito, Alfonso
   Lanza, Gaetano Antonio
   Le Pera, Domenica
   De Armas, Liala
   Sgueglia, Gregory Angelo
   Infusino, Fablo
   Millucci, Roberto
   Tonali, Pietro Attillo
   Crea, Filippo
   Valeriarni, Massimillano
TI Spinal cord stimulation normalizes abnormal cortical pain processing in
   patients with cardiac syndrome X
SO PAIN
LA English
DT Article
DE Spinal cord stimulation; Angina pectoris; Laser evoked potential
ID NOXIOUS INHIBITORY CONTROLS; NORMAL CORONARY ARTERIOGRAMS; REFRACTORY
   ANGINA-PECTORIS; LASER-EVOKED POTENTIALS; CHEST-PAIN; CONVERGENT
   NEURONS; BRAIN; MECHANISMS; ARTERIES; STRESS
AB Cardiac syndrome X (CSX) is characterized by effort angina, ST-segment depression during stress tests and normal corollary arteries. Abnormal nociception was suggested in these patients by Studies showing a reduced cardiac pain threshold: furthermore. we recently found a lack of habituation to pain stimuli using recording of laser evoked potentials (LEPs). In CSX patients with severe angina. spinal cord stimulation (SCS) was shown to improve symptoms. In this study we investigated whether, in these patients, SCS has any effects oil the excitability of the nociceptive system. assessed by LEPs recording. We studied 16 CSX patients (61.6 +/- 7 years: 4 men) who underwent SCS for refractory angina. Cortical LEPs were recorded during stimulation of the chest and right-hand during active SCS (SCS-ON) and in the absence of SCS (SCS-OFF). using a randomized cross-over design. Three sequences of painful stimuli were applied at each site during each test. During the first sequence of chest stimuli, the N2/P2 LEP amplitude was higher during the SCS-ON, compared to the SCS-OFF phase ( 18.2 +/- 7.8 vs. 11.5 +/- 4.4 mu V, P = 0.006). The N2/ 112 amplitude did not change significantly across the three stimulation sequences during the SCS-OFF phase (P = 0.22). whereas it decreased progressively during the second and third sequence (to 87.1 +/- 29.5% and 76.4 +/- 24.1%, respectively) compared with the first sequence. during the SCS-ON phase (P = 0.014). Similar results were observed during right-hand stimulation. Our study shows that in CSX patients SCS is able to restore habituation to peripheral pain stimuli. This effect might contribute to restore the ability of CSX patients to better tolerate cardiac pain. (C) 2008 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.
C1 [Sestito, Alfonso; Lanza, Gaetano Antonio; Sgueglia, Gregory Angelo; Infusino, Fablo; Crea, Filippo] Univ Cattolica Sacro Cuore, Ist Cardiol, I-00168 Rome, Italy.
   [Le Pera, Domenica; De Armas, Liala] IRCSS San Raffaele, Rome, Italy.
   [Millucci, Roberto; Valeriarni, Massimillano] IRCCS, Osped Pediat Bambino Gesu, Div Neurol, Rome, Italy.
   [Tonali, Pietro Attillo] Univ Cattolica Sacro Cuore, Ist Neurol, Rome, Italy.
C3 Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli;
   IRCCS Bambino Gesu; Catholic University of the Sacred Heart; IRCCS
   Policlinico Gemelli
RP Lanza, GA (corresponding author), Univ Cattolica Sacro Cuore, Ist Cardiol, Largo A Gemelli 8, I-00168 Rome, Italy.
EM g.a.lanza@inwind.it
RI Lanza, Gaetano/AAC-2660-2019; Valeriani, Massimiliano/AAA-4459-2020;
   Crea, Filippo/AAC-9754-2022; Infusino, Fabio/JEF-6750-2023; Sgueglia,
   Gregory/A-9701-2019; Valeriani, Massimiliano/K-5736-2016
OI Infusino, Fabio/0000-0001-9287-5936; Sgueglia,
   Gregory/0000-0001-9680-7412; Valeriani, Massimiliano/0000-0001-6602-103X
CR [Anonymous], ISCHEMIC HEART DIS
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NR 45
TC 25
Z9 29
U1 0
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0304-3959
EI 1872-6623
J9 PAIN
JI Pain
PD SEP 30
PY 2008
VL 139
IS 1
BP 82
EP 89
DI 10.1016/j.pain.2008.03.015
PG 8
WC Anesthesiology; Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Anesthesiology; Neurosciences & Neurology
GA 361WV
UT WOS:000260159200010
PM 18440702
DA 2025-06-11
ER

PT J
AU Spitzer, C
   Weihs, A
   Ewert, R
   Stubbe, B
   Penzel, T
   Fietze, I
   Völzke, H
   Grabe, HJ
AF Spitzer, Carsten
   Weihs, Antoine
   Ewert, Ralf
   Stubbe, Beate
   Penzel, Thomas
   Fietze, Ingo
   Voelzke, Henry
   Grabe, Hans J.
TI Childhood maltreatment and sleep apnea: Findings from a cross-sectional
   general population study
SO JOURNAL OF PSYCHOSOMATIC RESEARCH
LA English
DT Article
DE Childhood maltreatment; Sleep disturbances; Sleep apnea; Polysomnography
   (PSG); Apnea-hypopnea index (AHI); Oxygen desaturation index (ODI);
   General population
ID EYE-MOVEMENT SLEEP; SEXUAL-ABUSE; HEALTH; EXPERIENCES; TRAUMA; INSOMNIA;
   METAANALYSIS; PREVALENCE; VERSION; BIAS
AB Objective: Cumulative evidence indicates that childhood maltreatment (CM) is associated with sleep disturbances possibly suggesting sleep apnea. However, the relation between CM and objective measures of sleep apnea as determined by polysomnography (PSG) has not yet been assessed. Methods: Using a cross-sectional design and based on PSG measurements from N = 962 subjects from the SHIPTrend general population study, we used linear regression models to investigate the relationship between apneahypopnea (AHI) and oxygen desaturation index (ODI) and Epworth sleepiness scale (ESS) metrics and the Childhood Trauma Questionnaire (CTQ). All significant models were additionally adjusted for obesity, depression, metabolic syndrome, risky health behaviors, and socioeconomic factors. Results: While both AHI and ESS were positively associated with the CTQ sum score, ODI was not. Investigating the CTQ subscales, ESS was associated with emotional abuse and emotional neglect; AHI was associated with physical and sexual abuse as well as physical neglect. For both the sum score and the subscales of the CTQ, ESS effects were partially mediated by depressive symptoms, while AHI effects were mediated by obesity, risky health behaviors, and metabolic syndrome. Conclusion: The findings of this general population study suggest an association between CM, particularly physical neglect, and objective as well as subjective indicators of sleep apnea, which were partially mediated by depressive symptoms and obesity.
C1 [Spitzer, Carsten] Univ Med Rostock, Dept Psychosomat Med & Psychotherapy, Rostock, Germany.
   [Weihs, Antoine; Grabe, Hans J.] Univ Med Greifswald, Dept Psychiat & Psychotherapy, Greifswald, Germany.
   [Ewert, Ralf; Stubbe, Beate] Univ Med Greifswald, Dept Internal Med Cardiol B, Pulm Med Infect Dis & Intens Care, Greifswald, Germany.
   [Penzel, Thomas; Fietze, Ingo] Univ Hosp Charite Berlin, Ctr Sleep Med, Berlin, Germany.
   [Voelzke, Henry] Univ Greifswald, Dept Community Med, SHIP Clin Epidemiol Res, Greifswald, Germany.
   [Voelzke, Henry] German Ctr Diabet Res DZD, Partner Site Greifswald, Greifswald, Germany.
   [Voelzke, Henry] German Ctr Cardiovasc Res DZHK, Site Greifswald, Greifswald, Germany.
   [Grabe, Hans J.] German Ctr Neurodegenerat Dis DZNE, Site Rostock Greifswald, Greifswald, Germany.
   [Spitzer, Carsten] Univ Med Rostock, Dept Psychosomat Med & Psychotherapy, Gehlsheimer Str 20, D-18147 Rostock, Germany.
C3 University of Rostock; Universitat Greifswald; Greifswald Medical
   School; Universitat Greifswald; Greifswald Medical School; Berlin
   Institute of Health; Free University of Berlin; Humboldt University of
   Berlin; Charite Universitatsmedizin Berlin; Universitat Greifswald;
   German Center for Diabetes Research (DZD); German Centre for
   Cardiovascular Research; Helmholtz Association; German Center for
   Neurodegenerative Diseases (DZNE); University of Rostock
RP Spitzer, C (corresponding author), Univ Med Rostock, Dept Psychosomat Med & Psychotherapy, Gehlsheimer Str 20, D-18147 Rostock, Germany.
EM carsten.spitzer@med.uni-rostock.de
RI ; Penzel, Thomas/M-2344-2014
OI Fietze, Ingo/0000-0001-5567-5206; Weihs, Antoine/0000-0002-7113-0027;
   Penzel, Thomas/0000-0002-4304-0112
FU German Federal State of Mecklenburg-West Pomerania; Siemens
   Healthineers, Erlangen, Germany; Federal State of Mecklenburg-West
   Pomerania; German RLS organization (Deutsche Restless Legs Vereinigung);
   EU Joint Programme-Neurodegenerative Disease Research [01ED1615];
   National Institutes of Health (NIH) [AG059421]; Deutsche
   Forschungsgemeinschaft (DFG) [GR1912/13-1, GR1912/13-2]
FX The Study of Health in Pomerania (SHIP) is part of the Community
   Medicine Research net (CMR) (http:// www.medizin.uni-greifswald. de/icm)
   of the University Medicine Greifswald, which is supported by the German
   Federal State of Mecklenburg-West Pomerania. MRI scans in SHIP-Trend
   have been supported by a joint grant from Siemens Healthineers,
   Erlangen, Germany, and the Federal State of Mecklenburg-West Pomerania.
   PSG assessment was in part supported by the German RLS organization
   (Deutsche Restless Legs Vereinigung) . This study was further supported
   by EU Joint Programme-Neurodegenerative Disease Research funding for
   BRIDGET [grant number 01ED1615] , the National Institutes of Health
   (NIH) [grant number AG059421] and the Deutsche Forschungsgemeinschaft
   (DFG) [GR1912/13-1 and GR1912/13-2] .
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NR 62
TC 0
Z9 0
U1 1
U2 4
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-3999
EI 1879-1360
J9 J PSYCHOSOM RES
JI J. Psychosomat. Res.
PD MAR
PY 2024
VL 178
AR 111600
DI 10.1016/j.jpsychores.2024.111600
EA FEB 2024
PG 9
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA KZ2E7
UT WOS:001183718100001
PM 38340571
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Jan, A
   Shah, M
   Shah, SA
   Habib, SH
   Ehtesham, E
   Ahmed, N
AF Jan, Amin
   Shah, Mohsin
   Shah, Shahid Ali
   Habib, Syed Hamid
   Ehtesham, Ehtesham
   Ahmed, Naseer
TI Melatonin rescues pregnant female mice and their juvenile offspring from
   high fat diet-induced alzheimer disease neuropathy
SO HELIYON
LA English
DT Article
DE HFD; Obesity; Neuroinflammation; Neurodegeneration; Melatonin treatment;
   Synaptic dysfunction; ROS; Oxidative stress; SIRT1/Nrf2
ID BRAIN INSULIN-RESISTANCE; METABOLIC SYNDROME; INFLAMMATION; DYSFUNCTION;
   IMPAIRMENT; INDUCTION; COGNITION; BEHAVIOR; OBESITY; IMPACT
AB High fat diet (HFD) is a prime factor, which contributes to the present epidemic of metabolic syndrome. Prolonged intake of HFD induces oxidative stress (OS) that in turn causes neuroinflammation, neurodegeneration, insulin resistance, amyloid burden, synaptic dysfunction and cognitive impairment hence leading to Alzheimer's disease neuropathy. Melatonin (secreted by the Pineal gland) has the potential to nullify the toxic effects of reactive oxygen species (ROS) and have been shown to ameliorate various complications induced by HFD in rodent models. This study aimed to assess the neurotherapeutic effects of melatonin on HFD-induced neuroinflammation and neurodegeneration mediated by OS in pregnant female mice and their offspring. Western blotting, immunohistochemistry and antioxidant enzyme assays were used for quantification of samples from the hippocampal region of the brain of pregnant albino mice and their offspring. Short- and long-term memory was assessed by Y-maze and Morris Water Maze tests. HFD significantly induced OS leading to AD like neuropathology in the pregnant mice and their offspring while melatonin administration simultaneously with the HFD significantly prevented this neuropathy. This study reports that melatonin exerts these effects through the stimulation of SIRT1/Nrf2/HO-1 pathway that in turn reduces the HFD-induced OS and its downstream signaling. In conclusion melatonin prevents HFD-induced multiple complications that ultimately leads to the memory dysfunction in pregnant female mice and their successive generation via activation of SIRT1/Nrf2 signaling pathway.
C1 [Jan, Amin; Shah, Mohsin; Habib, Syed Hamid; Ehtesham, Ehtesham; Ahmed, Naseer] Khyber Med Univ, Inst Basic Med Sci, Peshawar, Pakistan.
   [Shah, Shahid Ali] Haripur Univ, Dept Biochem, Haripur, Pakistan.
C3 Khyber Medical University
RP Shah, M (corresponding author), Khyber Med Univ, Inst Basic Med Sci, Dept Physiol, Peshawar, Pakistan.
EM mohsin.ibms@kmu.edu.pk
RI Habib, Syed/ITU-1299-2023
FU Organization of Research Innovation and commercialization of Khyber
   Medical University; Khyber Medical University [DIR/ORIC/REF/22/00003]
FX This research was supported by Organization of Research Innovation and
   commercialization of Khyber Medical University and the publication
   charges for this article are partially borne from Khyber Medical
   University publication fund (reference No. DIR/ORIC/REF/22/00003) .
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NR 68
TC 1
Z9 1
U1 0
U2 0
PU CELL PRESS
PI CAMBRIDGE
PA 50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA
EI 2405-8440
J9 HELIYON
JI Heliyon
PD SEP 15
PY 2024
VL 10
IS 17
AR e36921
DI 10.1016/j.heliyon.2024.e36921
EA AUG 2024
PG 14
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA E3B6I
UT WOS:001301789300001
PM 39281480
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Feillet-Coudray, C
   Fouret, G
   Casas, F
   Coudray, C
AF Feillet-Coudray, Christine
   Fouret, Gilles
   Casas, Francois
   Coudray, Charles
TI Impact of high dietary lipid intake and related metabolic disorders on
   the abundance and acyl composition of the unique mitochondrial
   phospholipid, cardiolipin
SO JOURNAL OF BIOENERGETICS AND BIOMEMBRANES
LA English
DT Review
DE Cardiolipin; Fatty acid; High fat diet; Metabolic syndrome;
   Mitochondria; Obesity; Oxidative stress; Steatosis
ID FATTY-ACID-COMPOSITION; RAT-LIVER MITOCHONDRIA; INDUCED DIABETIC-RATS;
   OXIDATIVE STRESS; SKELETAL-MUSCLE; SHOTGUN LIPIDOMICS; RAPESEED OIL;
   COMPLEX-I; FISH-OIL; HEART
AB Excessive dietary lipid intake, coupled with lack of exercise, are the major causes of the development and progression of metabolic syndrome features e. g. obesity, hepatic steatosis, insulin resistance, type 2 diabetes and cardiovascular diseases. These metabolic diseases are associated with both structural and functional alterations of mitochondria. Cardiolipin (CL) is a unique phospholipid that is almost exclusively localized in the mitochondrial inner membrane. Cardiolipin is at the heart of mitochondrial metabolism playing a key role in several processes of mitochondrial bioenergetics as well as in mitochondrial membrane stability and dynamics, and in many of the mitochondrial-dependent steps of apoptosis. Indeed, alterations to CL content and acyl chain profile have been associated with mitochondrial dysfunction in multiple tissues in Barth syndrome and in many other physio-pathological conditions. After a brief overview of the biological roles of CL, we highlight the consequences of lipid overload-related nutritional manipulations as well as related metabolic disorders on both CL content and its fatty acid composition in the major metabolic tissues, the heart, muscle and liver. The goal of this review is to fill a void in the CL literature concerning the effects of CL abundance and form that arise following high lipid supplementation and the related metabolic disorders.
C1 [Feillet-Coudray, Christine; Fouret, Gilles; Casas, Francois; Coudray, Charles] Ctr INRA Montpellier, UMR Dynam Musculaire & Metab 866, F-34060 Montpellier, France.
C3 Universite de Montpellier; INRAE
RP Feillet-Coudray, C (corresponding author), Ctr INRA Montpellier, UMR Dynam Musculaire & Metab 866, F-34060 Montpellier, France.
EM cfeillet@supagro.inra.fr
RI COUDRAY, Charles/AGG-4757-2022
OI Coudray, Charles/0000-0003-2680-7796; Francois,
   Casas/0000-0002-5535-8195
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NR 82
TC 26
Z9 29
U1 1
U2 40
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0145-479X
EI 1573-6881
J9 J BIOENERG BIOMEMBR
JI J. Bioenerg. Biomembr.
PD OCT
PY 2014
VL 46
IS 5
BP 447
EP 457
DI 10.1007/s10863-014-9555-y
PG 11
WC Biophysics; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biophysics; Cell Biology
GA AP9YW
UT WOS:000342439200010
PM 24951897
DA 2025-06-11
ER

PT J
AU Daubenmier, J
   Moran, PJ
   Kristeller, J
   Acree, M
   Bacchetti, P
   Kemeny, ME
   Dallman, M
   Lustig, RH
   Grunfeld, C
   Nixon, DF
   Milush, JM
   Goldman, V
   Laraia, B
   Laugero, KD
   Woodhouse, L
   Epel, ES
   Hecht, FM
AF Daubenmier, Jennifer
   Moran, Patricia J.
   Kristeller, Jean
   Acree, Michael
   Bacchetti, Peter
   Kemeny, Margaret E.
   Dallman, Mary
   Lustig, Robert H.
   Grunfeld, Carl
   Nixon, Douglas F.
   Milush, Jeffrey M.
   Goldman, Veronica
   Laraia, Barbara
   Laugero, Kevin D.
   Woodhouse, Leslie
   Epel, Elissa S.
   Hecht, Frederick M.
TI Effects of a mindfulness-based weight loss intervention in adults with
   obesity: A randomized clinical trial
SO OBESITY
LA English
DT Article
ID METABOLIC SYNDROME; DIABETES-MELLITUS; HEART-DISEASE; LIFE-STYLE;
   MORTALITY; STRESS; METAANALYSIS; INDIVIDUALS; IMPACT; INDEX
AB ObjectiveTo determine whether adding mindfulness-based eating and stress management practices to a diet-exercise program improves weight loss and metabolic syndrome components.
   MethodsIn this study 194 adults with obesity were randomized to a 5.5-month program with or without mindfulness training and identical diet-exercise guidelines. Intention-to-treat analyses with multiple imputation were used for missing data. The primary outcome was 18-month weight change.
   ResultsEstimated effects comparing the mindfulness to control arm favored the mindfulness arm in (a) weight loss at 12 months, -1.9 kg (95% CI: -4.5, 0.8; P=0.17), and 18 months, -1.7 kg (95% CI: -4.7, 1.2; P=0.24), though not statistically significant; (b) changes in fasting glucose at 12 months, -3.1 mg/dl (95% CI: -6.3, 0.1; P=0.06), and 18 months, -4.1 mg/dl (95% CI: -7.3, -0.9; P=0.01); and (c) changes in triglyceride/HDL ratio at 12 months, -0.57 (95% CI: -0.95, -0.18; P=0.004), and 18 months, -0.36 (95% CI: -0.74, 0.03; P=0.07). Estimates for other metabolic risk factors were not statistically significant, including waist circumference, blood pressure, and C-reactive protein.
   ConclusionsMindfulness enhancements to a diet-exercise program did not show substantial weight loss benefit but may promote long-term improvement in some aspects of metabolic health in obesity that requires further study.
C1 [Daubenmier, Jennifer; Moran, Patricia J.; Acree, Michael; Goldman, Veronica; Hecht, Frederick M.] Univ Calif San Francisco, Osher Ctr Integrat Med, San Francisco, CA 94143 USA.
   [Daubenmier, Jennifer; Dallman, Mary; Grunfeld, Carl; Laraia, Barbara; Epel, Elissa S.; Hecht, Frederick M.] Univ Calif San Francisco, Ctr Obes Assessment Study & Treatment, San Francisco, CA 94143 USA.
   [Daubenmier, Jennifer; Grunfeld, Carl; Milush, Jeffrey M.; Hecht, Frederick M.] Univ Calif San Francisco, Dept Med, San Francisco, CA USA.
   [Kristeller, Jean] Indiana State Univ, Dept Psychol, Terre Haute, IN 47809 USA.
   [Bacchetti, Peter] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA.
   [Kemeny, Margaret E.] Univ Calif San Francisco, Dept Psychiat, San Francisco, CA USA.
   [Dallman, Mary; Epel, Elissa S.] Univ Calif San Francisco, Dept Physiol, Box 0444, San Francisco, CA USA.
   [Lustig, Robert H.] Univ Calif San Francisco, Dept Pediat, San Francisco, CA USA.
   [Grunfeld, Carl] Vet Affairs Med Ctr, San Francisco, CA 94121 USA.
   [Nixon, Douglas F.] Univ Calif San Francisco, Div Expt Med, San Francisco, CA 94143 USA.
   [Nixon, Douglas F.] George Washington Univ, Dept Microbiol Immunol & Trop Med, Washington, DC USA.
   [Laraia, Barbara] Univ Calif Berkeley, Sch Publ Hlth, Berkeley, CA 94720 USA.
   [Laugero, Kevin D.; Woodhouse, Leslie] USDA, Western Human Nutr Res Ctr, Davis, CA USA.
C3 University of California System; University of California San Francisco;
   University of California System; University of California San Francisco;
   University of California System; University of California San Francisco;
   Indiana State University; University of California System; University of
   California San Francisco; University of California System; University of
   California San Francisco; University of California System; University of
   California San Francisco; University of California System; University of
   California San Francisco; US Department of Veterans Affairs; Veterans
   Health Administration (VHA); University of California System; University
   of California San Francisco; George Washington University; University of
   California System; University of California Berkeley; United States
   Department of Agriculture (USDA)
RP Daubenmier, J; Hecht, FM (corresponding author), Univ Calif San Francisco, Osher Ctr Integrat Med, San Francisco, CA 94143 USA.; Daubenmier, J; Hecht, FM (corresponding author), Univ Calif San Francisco, Ctr Obes Assessment Study & Treatment, San Francisco, CA 94143 USA.; Daubenmier, J; Hecht, FM (corresponding author), Univ Calif San Francisco, Dept Med, San Francisco, CA USA.
EM jennifer.daubenmier@ucsf.edu; rick.hecht@ucsf.edu
RI Lustig, Robert/O-9380-2019; Nixon, Douglas/AAU-5734-2020; Dallman,
   Mary/B-4816-2010; Epel, Elissa/ABI-6703-2022; Laraia,
   Barbara/GXG-1829-2022
OI Hecht, Frederick/0000-0002-5782-1171
FU NIH grants from the National Center for Complementary and Alternative
   Medicine (NCCAM) [P01AT005013, K24AT007827, K01AT004199]; National
   Center for Advancing Translational Sciences, UCSF-CTSI [UL1 TR000004];
   National Center for Complementary and Integrative Health [K24AT007827]
   Funding Source: NIH RePORTER; National Institute of Diabetes and
   Digestive and Kidney Diseases [P30DK098722] Funding Source: NIH RePORTER
FX This study was supported by NIH grants from the National Center for
   Complementary and Alternative Medicine (NCCAM) P01AT005013 (Hecht),
   K24AT007827 (Hecht), and K01AT004199 (Daubenmier), as well as the
   National Center for Advancing Translational Sciences, UCSF-CTSI Grant
   Number UL1 TR000004.
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NR 36
TC 97
Z9 112
U1 0
U2 48
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1930-7381
EI 1930-739X
J9 OBESITY
JI Obesity
PD APR
PY 2016
VL 24
IS 4
BP 794
EP 804
DI 10.1002/oby.21396
PG 11
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA DI6MM
UT WOS:000373613200008
PM 26955895
OA Green Published, Green Accepted, hybrid
DA 2025-06-11
ER

PT J
AU Chan, KC
   Pen, PJ
   Yin, MC
AF Chan, Kung-chi
   Pen, Pei-Jain
   Yin, Mei-chin
TI Anticoagulatory and Antiinflammatory Effects of Astaxanthin in Diabetic
   Rats
SO JOURNAL OF FOOD SCIENCE
LA English
DT Article
DE astaxanthin; coagulation; diabetes; reactive oxygen species
ID VON-WILLEBRAND-FACTOR; METABOLIC SYNDROME; OXIDATIVE STRESS; MESANGIAL
   CELLS; HYPERGLYCEMIA; COAGULATION; ATHEROTHROMBOSIS; NEUTROPHILS;
   DYSFUNCTION; CYTOKINES
AB Astaxanthin at 0.01 or 0.05% of the diet was supplied to diabetic rats for 12 wk. Astaxanthin intake significantly increased its deposit in plasma, and retained glutathione content, reduced the production of reactive oxygen species, interleukin-6, tumor necrosis factor-a, and monocyte chemoattractant protein-1 in blood and kidney of diabetic rats (P < 0.05). Astaxanthin treatments also significantly decreased plasma levels of C-reactive protein and von Willebrand factor in diabetic rats (P < 0.05). Astaxanthin intake at 0.05% significantly diminished plasminogen activator inhibitor-1 and factor VII activities, enhanced antithrombin-III and protein C activities in circulation (P < 0.05). These results support that astaxanthin could attenuate diabetes associated coagulatory, oxidative, and inflammatory stress.
C1 [Yin, Mei-chin] Asia Univ, Dept Hlth & Nutr Biotechnol, Taichung, Taiwan.
   [Yin, Mei-chin] China Med Univ, Dept Nutr, Taichung, Taiwan.
   [Chan, Kung-chi; Pen, Pei-Jain] Providence Univ, Dept Food & Nutr, Taichung, Taiwan.
C3 Asia University Taiwan; China Medical University Taiwan; Providence
   University - Taiwan
RP Yin, MC (corresponding author), Asia Univ, Dept Hlth & Nutr Biotechnol, Taichung, Taiwan.
EM mcyin@mail.cmu.edu.tw
FU Natl. Science Council, Taiwan, ROC [NSC 99-2320-B-126-001]
FX This study was supported by a grant from Natl. Science Council, Taiwan,
   ROC (NSC 99-2320-B-126-001).
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NR 32
TC 43
Z9 49
U1 0
U2 24
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-1147
EI 1750-3841
J9 J FOOD SCI
JI J. Food Sci.
PD FEB
PY 2012
VL 77
IS 2
BP H76
EP H80
DI 10.1111/j.1750-3841.2011.02558.x
PG 5
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA 897YU
UT WOS:000300700100014
PM 22309505
DA 2025-06-11
ER

PT J
AU Kim, HJ
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AF Kim, Ho Joon
   Shin, Sam Yi
   Jeong, Seong Hoon
TI Nature and Extent of Physical Comorbidities Among Korean Patients With
   Mental Illnesses: Pairwise and Network Analysis Based on Health
   Insurance Claims Data
SO PSYCHIATRY INVESTIGATION
LA English
DT Article
DE Physical comorbidity; Healthcare system; Comorbidity network; Health
   insurance claims data; Severe mental
ID GENERAL-POPULATION; DISORDERS; SCHIZOPHRENIA; DEPRESSION;
   MULTIMORBIDITY; ASSOCIATION; PERSPECTIVE; BEHAVIORS; MORTALITY; PEOPLE
AB Objective The nature of physical comorbidities in patients with mental illness may differ according to diagnosis and personal charac-teristics. We investigated this complexity by conventional logistic regression and network analysis. Methods A health insurance claims data in Korea was analyzed. For every combination of psychiatric and physical diagnoses, odds ra-tios were calculated adjusting age and sex. From the patient-diagnosis data, a network of diagnoses was constructed using Jaccard coeffi-cient as the index of comorbidity. Results In 1,017,024 individuals, 77,447 (7.6%) were diagnosed with mental illnesses. The number of physical diagnoses among them was 11.2, which was 1.6 times higher than non-psychiatric groups. The most noticeable associations were 1) neurotic illnesses with gas-trointestinal/pain disorders and 2) dementia with fracture, Parkinson's disease, and cerebrovascular accidents. Unexpectedly, the diagno-sis of metabolic syndrome was only scarcely found in patients with severe mental illnesses (SMIs). However, implicit associations be-tween metabolic syndrome and SMIs were suggested in comorbidity networks. Conclusion Physical comorbidities in patients with mental illnesses were more extensive than those with other disease categories. However, the result raised questions as to whether the medical resources were being diverted to less serious conditions than more urgent conditions in patients with SMIs.
C1 [Kim, Ho Joon; Jeong, Seong Hoon] Eulji Univ, Daejeon Eulji Med Ctr, Dept Psychiat, Sch Med, 77 Gyeryong Ro 771beon Gil, Daejeon 34824, South Korea.
   [Shin, Sam Yi] Healers Hosp, Dept Psychiat, Busan, South Korea.
C3 Eulji University
RP Jeong, SH (corresponding author), Eulji Univ, Daejeon Eulji Med Ctr, Dept Psychiat, Sch Med, 77 Gyeryong Ro 771beon Gil, Daejeon 34824, South Korea.
EM AnselmJeong@gmail.com
RI Jeong, Seong/NES-0289-2025
OI Shin, Sam Yi/0000-0003-2268-3968
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NR 60
TC 2
Z9 2
U1 0
U2 4
PU KOREAN NEUROPSYCHIATRIC ASSOC
PI SEOUL
PA RN 522, G-FIVE CENTRAL PLAZA 1685-8 SEOCHO 4-DONG, SEOCHO-GU, SEOUL,
   137-882, SOUTH KOREA
EI 1976-3026
J9 PSYCHIAT INVEST
JI Psychiatry Investig.
PD JUN
PY 2022
VL 19
IS 6
BP 488
EP 499
DI 10.30773/pi.2022.0068
PG 12
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 3L7KL
UT WOS:000834939900011
PM 35753688
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Segura, AG
   Martínez-Pinteño, A
   Gassó, P
   Rodríguez, N
   Bioque, M
   Cuesta, MJ
   González-Peñas, J
   García-Rizo, C
   Lobo, A
   González-Pinto, A
   García-Alcón, A
   Roldán, A
   Vista, E
   Castro-Fornieles, J
   Mané, A
   Saiz, J
   Bernardo, M
   Mas, S
AF Segura, Alex G.
   Martinez-Pinteno, Albert
   Gasso, Patricia
   Rodriguez, Natalia
   Bioque, Miquel
   Cuesta, Manuel J.
   Gonzalez-Penas, Javier
   Garcia-Rizo, Clemente
   Lobo, Antonio
   Gonzalez-Pinto, Ana
   Garcia-Alcon, Alicia
   Roldan, Alexendra
   Vista, Eduard
   Castro-Fornieles, Josefina
   Mane, Anne
   Saiz, Jeronimo
   Bernardo, Miguel
   Mas, Sergi
CA PEPs Grp
TI Metabolic polygenic risk scores effect on antipsychotic-induced
   metabolic dysregulation: A longitudinal study in a first episode
   psychosis cohort
SO SCHIZOPHRENIA RESEARCH
LA English
DT Article
DE Psychotic disorders; Metabolic syndrome; Polygenic risk score
ID 1ST-EPISODE PSYCHOSIS; BIPOLAR DISORDER; SCHIZOPHRENIA; ASSOCIATION;
   ABNORMALITIES; METAANALYSIS; PREVALENCE; PSYCHIATRY; PEOPLE; DRUGS
AB Objective: Metabolic syndrome is a health-threatening condition suffered by approximately one third of schizophrenia patients and largely attributed to antipsychotic medication. Previous evidence reports a common genetic background of psychotic and metabolic disorders. In this study, we aimed to assess the role of polygenic risk scores (PRSs) on the progression of the metabolic profile in a first-episode psychosis (FEP) cohort. Method: Of the 231 FEP individuals included in the study, 192-220 participants were included in basal analysis and 118-179 in longitudinal 6-month models. Eleven psychopathologic and metabolic PRSs were constructed. Basal and longitudinal PRSs association with metabolic measurements was assessed by statistical analyses.Results: No major association of psychopathological PRSs with the metabolic progression was found. However, high risk individuals for depression and cholesterol-related PRSs reported a higher increase of cholesterol levels during the follow-up (FDR <= 0.023 for all analyses). Their effect was comparable to other well-established pharmacological and environmental risk factors (explaining at least 1.2% of total variance).Conclusion: Our findings provide new evidence of the effects of metabolic genetic risk on the development of metabolic dysregulation. The future establishment of genetic profiling tools in clinical procedures could enable practitioners to better personalize antipsychotic treatment selection and dosage.
C1 [Segura, Alex G.; Martinez-Pinteno, Albert; Gasso, Patricia; Rodriguez, Natalia; Mas, Sergi] Univ Barcelona, Dept Clin Fdn, Pharmacol Unit, Barcelona 08036, Spain.
   [Gasso, Patricia; Bioque, Miquel; Gonzalez-Penas, Javier; Garcia-Rizo, Clemente; Lobo, Antonio; Gonzalez-Pinto, Ana; Garcia-Alcon, Alicia; Roldan, Alexendra; Vista, Eduard; Castro-Fornieles, Josefina; Mane, Anne; Saiz, Jeronimo; Bernardo, Miguel; Mas, Sergi] Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid 28029, Spain.
   [Gasso, Patricia; Bioque, Miquel; Garcia-Rizo, Clemente] Inst Invest Biomed August Pi & Sunyer IDIBAPS, Barcelona 08036, Spain.
   [Bioque, Miquel; Garcia-Rizo, Clemente; Bernardo, Miguel] Hosp Clin Barcelona, Barcelona Clin Schizophrenia Unit, Neurosci Inst, Barcelona 08036, Spain.
   [Cuesta, Manuel J.] Complejo Hosp Navarra, Dept Psychiat, Pamplona 31008, Spain.
   [Cuesta, Manuel J.] Navarra Inst Hlth Res IdiSNA, Pamplona, Spain.
   [Gonzalez-Penas, Javier; Garcia-Alcon, Alicia] Inst Invest Sanitaria Gregorio Maran IiSGM, Hosp Gen Univ Gregorio Maranon, Inst Psychiat & Mental Hlth, Dept Child & Adolescent Psychiat, Madrid 28007, Spain.
   [Lobo, Antonio] Univ Zaragoza, Dept Med & Psychiat, Zaragoza 50009, Spain.
   [Lobo, Antonio] Inst Invest Sanitaria Aragon IIS Aragon, Zaragoza 50009, Spain.
   [Gonzalez-Pinto, Ana] Hosp Univ Alava, Vitoria 01009, Spain.
   [Gonzalez-Pinto, Ana] Inst Invest Sanitaria Bioaraba, Vitoria 01009, Spain.
   [Gonzalez-Pinto, Ana] Univ Basque Country, Vizcaya 48940, Spain.
   [Roldan, Alexendra] Univ Autonoma Barcelona, Hosp Santa Creu & St Pau, Inst Invest Biomed St Pau IIB SANTPAU, Psychiat Dept, Barcelona 08041, Spain.
   [Vista, Eduard] Hosp Clin Barcelona, Barcelona 08036, Spain.
   [Vista, Eduard; Bernardo, Miguel] Univ Barcelona, Dept Med, Barcelona 08036, Spain.
   [Castro-Fornieles, Josefina] Hosp Clin Barcelona, Clin Inst Neurosci, Dept Child & Adolescent Psychiat & Psychol, Barcelona 08036, Spain.
   [Mane, Anne] Autonomous Univ Barcelona, Hosp del Mar Med Res Inst IMIM, Barcelona 08003, Spain.
   [Saiz, Jeronimo] Univ Alcala, Hosp Univ Ramon & Cajal, IRYCIS, Madrid 28034, Spain.
C3 University of Barcelona; CIBER - Centro de Investigacion Biomedica en
   Red; CIBERSAM; University of Barcelona; Hospital Clinic de Barcelona;
   IDIBAPS; University of Barcelona; Hospital Clinic de Barcelona; Servicio
   Navarro de Salud - Osasunbidea; University of Navarra; General
   University Gregorio Maranon Hospital; University of Zaragoza; University
   Hospital of Araba; Bioaraba Health Research Institute; University of
   Basque Country; Autonomous University of Barcelona; Hospital of Santa
   Creu i Sant Pau; University of Barcelona; Hospital Clinic de Barcelona;
   University of Barcelona; University of Barcelona; Hospital Clinic de
   Barcelona; Hospital del Mar Research Institute; Hospital del Mar;
   Autonomous University of Barcelona; Universidad de Alcala; Hospital
   Universitario Ramon y Cajal
RP Mas, S (corresponding author), Univ Barcelona, Dept Clin Fdn, IDIBAPS, CIBERSAM, Casanova 143, E-08036 Barcelona, Spain.
EM sergimash@ub.edu
RI Rodriguez, Natalia/HNB-5559-2023; Martínez-Pinteño,
   Albert/GWM-5523-2022; Bernardo, Miquel/P-3049-2015; González-Peñas,
   Javier/ABC-8818-2021; Torres, Miguel/HZK-8113-2023; Gasso,
   Patricia/KEI-8686-2024; Vieta, Eduard/Y-2919-2019; Di Carlo,
   Antonio/AAB-9776-2022; Cuesta, Manuel/HLX-6728-2023; Mas,
   Sergi/AAD-1996-2019; Rivero, Olga/AAA-8059-2020; Vieta,
   Eduard/I-6330-2013; Bioque, Miquel/ACC-0014-2022; garcia-rizo,
   clemente/C-5520-2019
OI GARCIA ALCON, ALICIA/0000-0003-1777-1795; Mas,
   Sergi/0000-0003-3336-6298; Gonzalez-Penas, Javier/0000-0002-3850-3012;
   Segura, Alex G/0000-0002-9398-2183; Rivero, Olga/0000-0002-2664-4053;
   mane santacana, anna/0000-0003-2127-349X; Vieta,
   Eduard/0000-0002-0548-0053; Martinez Pinteno,
   Albert/0000-0003-2035-5979; Bioque, Miquel/0000-0001-6887-7149;
   garcia-rizo, clemente/0000-0002-4855-1608; Gasso,
   Patricia/0000-0001-6930-3454
CR [Anonymous], 1994, DSM 4
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NR 56
TC 13
Z9 13
U1 2
U2 10
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0920-9964
EI 1573-2509
J9 SCHIZOPHR RES
JI Schizophr. Res.
PD JUN
PY 2022
VL 244
BP 101
EP 110
DI 10.1016/j.schres.2022.05.021
EA MAY 2022
PG 10
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 2A6PY
UT WOS:000809622900002
PM 35659654
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Antonino, C
   Vitale, E
   Bardone, L
AF Antonino, Calabro
   Vitale, Elsa
   Bardone, Lorenzo
TI Sex-Related Differences Linked to Depression Disorders and Chronic
   Inflammation Diseases in Nursing Shift Workers: An Expsloratory
   Multidimensional Literature Review
SO ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS
LA English
DT Review
DE Depression; inflammation; sex; shift nurses; gender role; nursing;
   medicine; rheumatologically diseases
ID LOW-BACK-PAIN; CAUSE-SPECIFIC MORTALITY; C-REACTIVE PROTEIN; ITALIAN
   NURSES; METABOLIC SYNDROME; SLEEP DISTURBANCE; RISK-FACTORS; PREVALENCE;
   WORKING; GENDER
AB Objective The objective of this literature review is to explore how depression and inflammatory conditions relate to gender among nurses working shifts. Methods Relevant studies available on the PubMed database over the past decade were consulted. The main keywords were: "shift nurses", "depression", "gender Shift Nurses", "Gender Role", "shift nurse", "gender roles", "Inflammation" and then, free terms were combined with the Boolean AND operator. Inclusion and exclusion criteria had been formerly identified, and then, all the selected studies were assessed according to the following criteria, good description, and appropriateness of study design (objective and method), sample (sufficiently numerous, clarity of treatment allocation criteria, absence of important bias), intervention, outcomes, statistical analysis, and clinical relevance. Results 61 titles concerning research on inflammation were found. 28 titles were not taken into account as doubles whilst 33 were selected by title and abstract; in addition, 28 were discarded because they were not relevant to the objective or because they did not meet the inclusion criteria. Out of the remaining 5, a further 2 were also discarded upon a careful analysis of the whole text: they did not prove relevant to the research question. As for the research related to depression, the research strategy highlighted 186 articles in the first place and then eliminated 165 of them either because they were duplicates or on the grounds that they did not answer the research questions; 21 texts were thoroughly analyzed and, after a careful read, 4 studies were eventually incorporated in this review. Conclusion Since data available in the literature were inconsistent, it was difficult to establish that all depression conditions could be associated with an increase in inflammation and vice versa and that this condition was strictly connected to the female gender.
C1 [Antonino, Calabro] Nuovo Osped Infermi, Local Hlth Author Biella, Biella, Italy.
   [Vitale, Elsa] Local Hlth Co Bari, Ctr Mental Hlth, Bari, Italy.
   [Bardone, Lorenzo] Univ Piemonte Orientale, Biella Headquarters, Biella, Italy.
   [Vitale, Elsa] Via X Marzo 43, I-70026 Bari, Italy.
C3 University of Eastern Piedmont Amedeo Avogadro
RP Vitale, E (corresponding author), Local Hlth Co Bari, Ctr Mental Hlth, Bari, Italy.; Vitale, E (corresponding author), Via X Marzo 43, I-70026 Bari, Italy.
EM vitaleelsa@libero.it
RI Vitale, Elsa/D-8904-2018
OI Vitale, Elsa/0000-0002-9738-3479; Calabro, Antonino/0000-0003-2843-6693
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NR 93
TC 3
Z9 3
U1 0
U2 0
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1871-5303
EI 2212-3873
J9 ENDOCR METAB IMMUNE
JI Endocr. Metab. Immune Disord.-Drug Targets
PY 2022
VL 22
IS 13
BP 1293
EP 1302
DI 10.2174/1871530322666220620101323
PG 10
WC Endocrinology & Metabolism; Immunology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Immunology; Pharmacology & Pharmacy
GA 7A9MU
UT WOS:000898771900007
PM 35726431
DA 2025-06-11
ER

PT J
AU Nicholson, T
   Church, C
   Tsintzas, K
   Jones, R
   Breen, L
   Davis, ET
   Baker, DJ
   Jones, SW
AF Nicholson, Thomas
   Church, Chris
   Tsintzas, Kostas
   Jones, Robert
   Breen, Leigh
   Davis, Edward T.
   Baker, David J.
   Jones, Simon W.
TI Vaspin promotes insulin sensitivity in elderly muscle and is upregulated
   in obesity
SO JOURNAL OF ENDOCRINOLOGY
LA English
DT Article
DE skeletal muscle; adipokines; insulin; obesity; myotubes; adipose tissue
ID ADIPOSE-TISSUE MACROPHAGES; GLUT4 EXPRESSION; SKELETAL-MUSCLE;
   GLUCOSE-UPTAKE; METABOLIC SYNDROME; GENE-EXPRESSION; SEX-DIFFERENCES;
   SERUM-LEVELS; ER STRESS; P38 MAPK
AB Adipokines have emerged as central mediators of insulin sensitivity and metabolism, in part due to the known association of obesity with metabolic syndrome disorders such as type 2 diabetes. Recent studies in rodents have identified the novel adipokine vaspin as playing a protective role in inflammatory metabolic diseases by functioning as a promoter of insulin sensitivity during metabolic stress. However, at present the skeletal muscle and adipose tissue expression of vaspin in humans is poorly characterised. Furthermore, the functional role of vaspin in skeletal muscle insulin sensitivity has not been studied. Since skeletal muscle is the major tissue for insulin-stimulated glucose uptake, understanding the functional role of vaspin in human muscle insulin signalling is critical in determining its role in glucose homeostasis. The objective of this study was to profile the skeletal muscle and subcutaneous adipose tissue expression of vaspin in humans of varying adiposity, and to determine the functional role of vaspin in mediating insulin signalling and glucose uptake in human skeletal muscle. Our data shows that vaspin is secreted from both human subcutaneous adipose tissue and skeletal muscle, and is more highly expressed in obese older individuals compared to lean older individuals. Furthermore, we demonstrate that vaspin induces activation of the PI3K/AKT axis, independent of insulin receptor activation, promotes GLUT4 expression and translocation and sensitises older obese human skeletal muscle to insulin-mediated glucose uptake.
C1 [Nicholson, Thomas; Breen, Leigh; Jones, Simon W.] Univ Birmingham, MRC ARUK Ctr Musculoskeletal Ageing Res, Inst Inflammat & Ageing, Birmingham, W Midlands, England.
   [Church, Chris; Baker, David J.] MedImmune, Cardiovasc & Metab Dis CVMD, Milstein Bldg, Cambridge, England.
   [Tsintzas, Kostas; Jones, Robert] Univ Nottingham, MRC ARUK Ctr Musculoskeletal Ageing Res, Fac Med & Hlth Sci, Sch Life Sci, Nottingham, England.
   [Davis, Edward T.] Royal Orthopaed Hosp NHS Fdn Trust, Birmingham, W Midlands, England.
C3 University of Birmingham; AstraZeneca; Medimmune; University of
   Nottingham; Royal Orthopaedic Hospital
RP Jones, SW (corresponding author), Univ Birmingham, MRC ARUK Ctr Musculoskeletal Ageing Res, Inst Inflammat & Ageing, Birmingham, W Midlands, England.
EM S.W.Jones@bham.ac.uk
RI Jones, Simon/ABB-8625-2020; Breen, Leigh/AAO-7302-2021
OI Breen, Leigh/0000-0001-6669-4816; Jones, Simon/0000-0001-6785-2310
FU BBSRC; MedImmune/AstraZeneca [BB/N504002/1]; BBSRC [1733068] Funding
   Source: UKRI; MRC [MR/P021220/1] Funding Source: UKRI
FX T N was funded by a BBSRC Case PhD studentship with
   MedImmune/AstraZeneca (BB/N504002/1).
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NR 63
TC 35
Z9 36
U1 0
U2 5
PU BIOSCIENTIFICA LTD
PI BRISTOL
PA EURO HOUSE, 22 APEX COURT WOODLANDS, BRADLEY STOKE, BRISTOL BS32 4JT,
   ENGLAND
SN 0022-0795
EI 1479-6805
J9 J ENDOCRINOL
JI J. Endocrinol.
PD APR
PY 2019
VL 241
IS 1
BP 31
EP 43
DI 10.1530/JOE-18-0528
PG 13
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA HN6QD
UT WOS:000460309900004
PM 30721136
OA Green Published, Green Submitted, hybrid
DA 2025-06-11
ER

PT J
AU Meepring, S
   Chien, WT
   Gray, R
   Bressington, D
AF Meepring, Soontareeporn
   Chien, Wai Tong
   Gray, Richard
   Bressington, Daniel
TI Effects of the Thai Health Improvement Profile intervention on the
   physical health and health behaviours of people with schizophrenia: A
   quasi-experimental study
SO INTERNATIONAL JOURNAL OF MENTAL HEALTH NURSING
LA English
DT Article
DE BMI; health behaviours; physical health; schizophrenia; severe mental
   illness
ID SERIOUS MENTAL-ILLNESS; METABOLIC SYNDROME; WEIGHT-GAIN; DRUG-NAIVE;
   PREVALENCE; METAANALYSIS; 1ST-EPISODE; MORTALITY; CRITERIA; PROGRAM
AB Physical health problems and unhealthy lifestyle behaviours are common in people with severe mental illness (SMI), leading to high levels of mortality.There is some evidence that nurse-led interventions involving comprehensive health checks may be effective in improving physical health in people with SMI. This quasi-experimental before-and-after study investigated the impacts of the Thai Health Improvement Profile (HIP-T) on the physical health and health behaviours of people with schizophrenia over 1-year. All 105 service-users who volunteered to participate completed the study. There were significant reductions in mean BMI (-0.78kg/m(2), P<.001) and bodyweight (-1.13kg, P<.001) at post-test. There was also a significant decrease in the total number of red-flagged HIP-T items, suggesting lowered potential health risks (P<.001). Overall, 23 patients (22%) were found to have moved to a healthier BMI classification after 1-year. The findings suggest that the HIP-T intervention has potential for improving the physical health of people with SMI when integrated into routine community mental health care.
C1 [Meepring, Soontareeporn] Naresuan Univ, Mental Hlth & Psychiat Nursing Div, Dept Nursing, Phitsanulok, Thailand.
   [Chien, Wai Tong; Bressington, Daniel] Hong Kong Polytech Univ, Mental Hlth Care Res Grp, Sch Nursing, Hong Kong, Hong Kong, Peoples R China.
   [Gray, Richard] Hamad Med Corp, Hlth Serv Res Ctr, Doha, Qatar.
   [Gray, Richard] La Trobe Univ, Dept Nursing, Melbourne, Vic, Australia.
C3 Naresuan University; Hong Kong Polytechnic University; Hamad Medical
   Corporation; La Trobe University
RP Bressington, D (corresponding author), Hong Kong Polytech Univ, Sch Nursing, Kowloon, Hong Kong, Peoples R China.
EM dan.bressington@polyu.edu.hk
RI Gray, Richard/C-9945-2017; Chien, Wai Tong/M-6106-2019; Bressington,
   Daniel/G-2789-2017; Chien, Wai Tong/F-9604-2014
OI Bressington, Daniel/0000-0003-0951-2208; Meepring, Thongsai,
   Soontareeporn/0000-0001-5648-2908; Chien, Wai Tong/0000-0001-5321-5791
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NR 49
TC 13
Z9 14
U1 0
U2 9
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1445-8330
EI 1447-0349
J9 INT J MENT HEALTH NU
JI Int. J. Ment. Health Nurs.
PD FEB
PY 2018
VL 27
IS 1
BP 126
EP 137
DI 10.1111/inm.12301
PG 12
WC Nursing; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Psychiatry
GA FS3XF
UT WOS:000419717100012
PM 27982537
DA 2025-06-11
ER

PT J
AU Yang, XY
   Feng, C
   Feng, JP
AF Yang, Xueyuan
   Feng, Chao
   Feng, Jinping
TI Epicardial Adipose Tissue and Diabetic Cardiomyopathy
SO JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS
LA English
DT Review
DE diabetic cardiomyopathy; epicardial adipose tissue; insulin resistance;
   oxidative stress; autophagy
ID BINDING-PROTEIN 4; CORONARY-ARTERY-DISEASE; LOW-DENSITY-LIPOPROTEIN;
   INSULIN-RESISTANCE; MACROPHAGE POLARIZATION; CARDIAC DYSFUNCTION;
   METABOLIC SYNDROME; SIGNALING PATHWAY; HEART-FAILURE; FAT
AB Diabetes is a long-term chronic disease, and cardiovascular disease is the leading cause of death. Diabetic cardiomyopathy (DCM), one of the cardiovascular complications of diabetes, has many uncertain factors. Epicardial fat, as the heart fat bank, functions as fatty tissue and is the heart's endocrine organ. The existence of diabetes affects the distribution of heart fat and promotes the secretion of adipokine. In different pathological conditions, it can promote the secretion of pro-inflammatory adipokine, reactive oxygen species, oxidative stress, and even autophagy, thus affecting cardiac function. In this paper, we will elaborate on the mechanism of epicardial fat in the pathogenesis of diabetic cardiomyopathy.
C1 [Yang, Xueyuan] Tianjin Med Univ, Chest Clin Coll, Tianjin, Peoples R China.
   [Feng, Chao; Feng, Jinping] Tianjin Chest Hosp, Tianjin, Peoples R China.
   [Feng, Jinping] Tianjin Chest Hosp, Tianjin 300222, Peoples R China.
C3 Tianjin Medical University
RP Feng, JP (corresponding author), Tianjin Chest Hosp, Tianjin 300222, Peoples R China.
EM chlfjp@sina.com
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NR 87
TC 7
Z9 7
U1 2
U2 10
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1074-2484
EI 1940-4034
J9 J CARDIOVASC PHARM T
JI J. Cardiovasc. Pharmacol. Ther.
PY 2023
VL 28
AR 10742484231151820
DI 10.1177/10742484231151820
PG 10
WC Cardiac & Cardiovascular Systems; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Pharmacology & Pharmacy
GA 8W4GL
UT WOS:000931293400001
PM 36752345
OA gold
DA 2025-06-11
ER

PT J
AU Ilincic, B
   Stokic, E
   Stosic, Z
   Kojic, NE
   Katsiki, N
   Mikhailidis, DP
   Isenovic, ER
AF Ilincic, Branislava
   Stokic, Edita
   Stosic, Zoran
   Kojic, Nevena Eremic
   Katsiki, Niki
   Mikhailidis, Dimitri P.
   Isenovic, Esma R.
TI Vitamin D status and circulating biomarkers of endothelial dysfunction
   and inflammation in non-diabetic obese individuals: a pilot study
SO ARCHIVES OF MEDICAL SCIENCE
LA English
DT Article
DE vitamin D; endothelial dysfunction; inflammation; obesity;
   cardiometabolic risk factors
ID C-REACTIVE PROTEIN; CARDIOVASCULAR RISK; OXIDATIVE STRESS; D DEFICIENCY;
   CELLS; METAANALYSIS; MECHANISMS; GLUCOSE; MARKERS; WEIGHT
AB Introduction: Obesity and inadequate vitamin D status are associated with endothelial dysfunction and cardiovascular disease. We evaluated the associations between vitamin D status (i.e. serum levels of 25-hydroxyvitamin D (25(OH)D)), biomarkers of endothelial dysfunction (i.e. serum concentrations of soluble intercellular adhesion molecule 1 (sICAM-1) and soluble E-selectin (sE-selectin)), inflammatory markers (i.e. high-sensitivity C-reactive protein (hsCRP) and fibrinogen) and cardiometabolic risk factors.
   Material and methods: Fifty obese (body mass index (BMI) >= 30 kg/m(2)) non-diabetic adults (mean age: 36.2 +/- 5.4 years) without pre-existing cardiovascular abnormalities and 25 clinically healthy, normal weight and age matched individuals were included. Anthropometric parameters, markers of glucose and lipid metabolism, and serum levels of inflammatory and endothelial dysfunction biomarkers were assessed in all subjects.
   Results: The mean serum 25(OH)D level was significantly lower in the obese group than in controls (33.5 +/- 15.2 vs. 60.1 +/- 23.1 nmol/l; p < 0.001). In the obese group, sE-selectin (36.4 (32.1-47.2) vs. 32.4 (24.6-35.5) ng/ml, p < 0.05) and hsCRP (6.0 +/- 3.4 vs. 3.5 1.0 mg/l, p < 0.05) were significantly higher in individuals with lower than median vitamin D levels (i.e. 31 nmol/l) compared with those with higher vitamin D levels. In multivariable linear regression analysis, hsCRP (beta = 0.43; p < 0.001) and sE-selectin (beta = 0.30; p = 0.03) were independently and significantly associated with serum 25(OH)D levels in the obese group.
   Conclusions: Vitamin D levels may be related to increased levels of biomarkers of endothelial dysfunction and inflammation in obese non-diabetic individuals.
C1 [Ilincic, Branislava; Stokic, Edita; Stosic, Zoran; Kojic, Nevena Eremic] Univ Novi Sad, Clin Ctr Vojvodina, Fac Med, Novi Sad, Serbia.
   [Katsiki, Niki] Aristotle Univ Thessaloniki, Sch Med, Propedeut Dept Internal Med 2, Hippokrat Hosp, Thessaloniki, Greece.
   [Mikhailidis, Dimitri P.] UCL, Sch Med, Dept Clin Biochem, Vasc Dis Prevent Clin, Royal Free Hosp Campus, London, England.
   [Isenovic, Esma R.] Univ Belgrade, Inst Vinca, Lab Mol Genet & Radiobiol, Belgrade, Serbia.
C3 University of Novi Sad; Aristotle University of Thessaloniki; University
   of London; University College London; UCL Medical School; Royal Free
   London NHS Foundation Trust; University of Belgrade
RP Ilincic, B (corresponding author), Univ Novi Sad, Fac Med, Dept Pathophysiol & Lab Med, HajdukVeljkova 3, Novi Sad 21000, Serbia.
EM branislava.ilincic@mf.uns.ac.rs
RI Mikhailidis, Dimitri/A-1869-2013; Isenovic, Esma/D-3017-2009; KATSIKI,
   NIKI/ADE-7999-2022
OI Isenovic, Esma/0000-0002-0012-2636; KATSIKI, NIKI/0000-0003-0894-2644
FU Ministry of Science, Education and Technological development, Republic
   of Serbia [173033]
FX This study was supported by a grant funded by the Ministry of Science,
   Education and Technological development, Republic of Serbia, No. 173033
   (to ERI).
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NR 44
TC 27
Z9 28
U1 0
U2 5
PU TERMEDIA PUBLISHING HOUSE LTD
PI POZNAN
PA KLEEBERGA ST 2, POZNAN, 61-615, POLAND
SN 1734-1922
EI 1896-9151
J9 ARCH MED SCI
JI Arch. Med. Sci.
PD FEB
PY 2017
VL 13
IS 1
BP 53
EP 60
DI 10.5114/aoms.2016.61812
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA EG3YS
UT WOS:000390981200003
PM 28144255
OA gold, Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Bayliak, MM
   Dmytriv, TR
   Melnychuk, AV
   Strilets, NV
   Storey, KB
   Lushchak, VI
AF Bayliak, Maria M.
   Dmytriv, Tetiana R.
   Melnychuk, Antonina, V
   Strilets, Nadia, V
   Storey, Kenneth B.
   Lushchak, Volodymyr, I
TI CHAMOMILE AS A POTENTIAL REMEDY FOR OBESITY AND METABOLIC SYNDROME
SO EXCLI JOURNAL
LA English
DT Review
DE Chamomile; polyphenols; inflammation; pro-oxidant; Nrf2; PPAR
ID ACTIVATED PROTEIN-KINASE; RECUTITA L. RAUSCHERT; MATRICARIA-CHAMOMILLA;
   ADIPOSE-TISSUE; OXIDATIVE STRESS; PPAR-GAMMA; INSULIN-RESISTANCE;
   ESSENTIAL OIL; ANTIMICROBIAL ACTIVITY; INFLAMMATORY RESPONSE
AB Obesity is an increasing health concern related to many metabolic disorders, including metabolic syndrome, diabetes type 2 and cardiovascular diseases. Many studies suggest that herbal products can be useful dietary supplements for weight management due to the presence of numerous biologically active compounds, including antioxidant polyphenols that can counteract obesity-related oxidative stress. In this review we focus on Matricaria chamomilla, commonly known as chamomile, and one of the most popular medicinal plants in the world. Thanks to a high content of phenolic compounds and essential oils, preparations from chamomile flowers demonstrate a number of pharmacological effects, including antioxidant, anti-inflammatory, antimicrobial and sedative actions as well as improving gastrointestinal function. Several recent studies have shown certain positive effects of chamomile preparations in the prevention of obesity and complications of diabetes. These effects were associated with modulation of signaling pathways involving the AMP-activated protein kinase, NF-kappa B, Nrf2 and PPAR. transcription factors. However, the potential of chamomile in the management of obesity seems to be underestimated. This review summarizes current data on the use of chamomile and its individual components (apigenin, luteolin, essential oils) to treat obesity and related metabolic disorders in cell and animal models and in human studies. Special attention is paid to molecular mechanisms that can be involved in the anti-obesity effects of chamomile preparations. Limitation of chamomile usage is also analyzed.
C1 [Bayliak, Maria M.; Dmytriv, Tetiana R.; Melnychuk, Antonina, V; Strilets, Nadia, V; Lushchak, Volodymyr, I] Vasyl Stefanyk Precarpathian Natl Univ, Dept Biochem & Biotechnol, 57 Shevchenko Str, UA-76018 Ivano Frankivsk, Ukraine.
   [Lushchak, Volodymyr, I] I Horbachevsky Ternopil Natl Med Univ, UA-46002 Ternopol, Ukraine.
   [Lushchak, Volodymyr, I] Res & Dev Univ, Shota Rustaveli Str, UA-76018 Ivano Frankivsk, Ukraine.
   [Storey, Kenneth B.] Carleton Univ, Inst Biochem, 1125 Colonel By Dr, Ottawa, ON K1S 5B6, Canada.
C3 Ministry of Education & Science of Ukraine; Vasyl Stefanyk Precarpathian
   National University; I. Horbachevsky Ternopil State Medical University;
   Carleton University
RP Bayliak, MM (corresponding author), Vasyl Stefanyk Precarpathian Natl Univ, Dept Biochem & Biotechnol, 57 Shevchenko Str, UA-76018 Ivano Frankivsk, Ukraine.
EM maria.bayliak@pnu.edu.ua
RI Storey, Kenneth/G-9883-2011; Lushchak, Volodymyr/AAV-4256-2021; Dmytriv,
   Tetiana/HLX-5759-2023; Bayliak, Maria/P-8950-2015
OI Bayliak, Maria/0000-0001-6268-8910; Dmytriv, Tetiana/0000-0001-9467-1267
FU Ministry of Education and Science of Ukraine [0118U003477]; National
   Research Foundation of Ukraine [2020.02/0118]
FX This work was partially supported by a grant from the Ministry of
   Education and Science of Ukraine (#0118U003477) to VIL and a grant from
   National Research Foundation of Ukraine (#2020.02/0118) to MMB.
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NR 150
TC 25
Z9 27
U1 1
U2 30
PU EXCLI JOURNAL MANAGING OFFICE
PI DORTMUND
PA LEIBNIZ RESEARCH CENTRE WORKING ENVIRONMENT & HUMAN FACTORS EXCLI
   JOURNAL, ARDEYSTR 67, DORTMUND, D-44139, GERMANY
SN 1611-2156
J9 EXCLI J
JI EXCLI J.
PY 2021
VL 20
DI 10.17179/excli2021-4013
PG 26
WC Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics
GA TX5CM
UT WOS:000683105200001
PM 34602925
DA 2025-06-11
ER

PT J
AU Thomas-Valdés, S
   Theoduloz, C
   Jiménez-Aspee, F
   Burgos-Edwards, A
   Schmeda-Hirschmann, G
AF Thomas-Valdes, Samanta
   Theoduloz, Cristina
   Jimenez-Aspee, Felipe
   Burgos-Edwards, Alberto
   Schmeda-Hirschmann, Guillermo
TI Changes in polyphenol composition and bioactivity of the native Chilean
   white strawberry (Fragaria chiloensis spp. chiloensis f.
   chiloensis) after in vitro gastrointestinal digestion
SO FOOD RESEARCH INTERNATIONAL
LA English
DT Article
DE Fragaria chiloensis; In vitro digestion; Polyphenolic profiles;
   Antioxidant activity; Metabolic syndrome-associated enzymes;
   HPLC-DAD-MS/MSn
ID ALPHA-GLUCOSIDASE; ANTIOXIDANT ACTIVITY; OXIDATIVE STRESS;
   RIBES-MAGELLANICUM; METABOLIC SYNDROME; AMYLASE; LIPASE; FRUITS;
   PROANTHOCYANIDINS; STABILITY
AB The Chilean white strawberry (Fragaria chiloensis spp. chiloensis f. chiloensis) is a semi-domesticated strawberry with high polyphenol content and antioxidant activity occurring in southern Chile. The aim of this work was to compare the composition and bioactivity of the polyphenol-enriched fruit extract (PEE) before and after simulated gastrointestinal digestion (GID). Results show a decrease by > 50% in the total phenolic (TP) content at the end of the GID, compared to the non-digested PEE. A reduction in the antioxidant capacity of the PEEs was observed after GID by means of DPPH, FRAP, TEAC and anion superoxide assays. After simulated GID the PEE significantly inhibited alpha-glucosidase with an IC50 value of 3.13 mu g/mL. The inhibition of pancreatic lipase was reduced by 95% after GID. All the PEEs did not show inhibitory effect towards alpha-amylase throughout the GID. In the same way, the PEEs did not significantly protect human gastric adenocarcinoma (AGS) cells against H2O2 induced stress. Thirty eight compounds were tentatively identified in the non-digested PEE. The compounds that were more affected by the simulated GID were simple phenolics. After the GID, only 33 and 25 compounds were detected, in the gastric and intestinal steps, respectively. These results evidence the changes elicited by GID on the bioactivity and polyphenolic composition of the white strawberry.
C1 [Thomas-Valdes, Samanta; Burgos-Edwards, Alberto; Schmeda-Hirschmann, Guillermo] Univ Talca, Inst Quim Recursos Nat, Lab Quim Prod Nat, Talca, Chile.
   [Theoduloz, Cristina] Univ Talca, Fac Ciencias Salud, Lab Cult Celular, Talca, Chile.
   [Jimenez-Aspee, Felipe] Univ Talca, Fac Ciencias Salud, Dept Ciencias Basicas Biomed, Talca, Chile.
   [Thomas-Valdes, Samanta] Univ Valparaiso, Fac Farm, Escuela Nutr & Dietet, Valparaiso, Chile.
C3 Universidad de Talca; Universidad de Talca; Universidad de Talca;
   Universidad de Valparaiso
RP Schmeda-Hirschmann, G (corresponding author), Univ Talca, Inst Quim Recursos Nat, Lab Quim Prod Nat, Talca, Chile.
EM schmeda@utalca.cl
RI Thomas-Valdés, Samanta/H-4807-2018; Aspee, Felipe/ABA-2948-2020; Jimenez
   Aspee, Felipe/G-6955-2017; Schmeda Hirschmann, Guillermo/G-1046-2010
OI Burgos-Edwards, Alberto/0000-0001-8286-8556; Thomas-Valdes,
   Samanta/0000-0002-1813-2728; Jimenez Aspee, Felipe/0000-0002-7285-7033;
   Schmeda Hirschmann, Guillermo/0000-0002-9228-5378
FU CONICYT-PCHA/Doctorado Nacional [2013-63130042, 2015-21151561]; Nucleo
   Cientifico Multidisciplinario; PIEI-QUIM-BIO, Universidad de Talca
FX Financial support from CONICYT-PCHA/Doctorado Nacional/2013-63130042 (S.
   Thomas-Valdes), CONICYT-PCHA/Doctorado Nacional/2015-21151561 (A. Burgos
   Edwards), Nucleo Cientifico Multidisciplinario and PIEI-QUIM-BIO,
   Universidad de Talca, are kindly acknowledged.
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NR 43
TC 40
Z9 42
U1 0
U2 72
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0963-9969
EI 1873-7145
J9 FOOD RES INT
JI Food Res. Int.
PD MAR
PY 2018
VL 105
BP 10
EP 18
DI 10.1016/j.foodres.2017.10.074
PG 9
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA FW8GJ
UT WOS:000425567900002
PM 29433189
DA 2025-06-11
ER

PT J
AU Di Bartolomeo, F
   Van den Ende, W
AF Di Bartolomeo, Francesca
   Van den Ende, Wim
TI Fructose and Fructans: Opposite Effects on Health?
SO PLANT FOODS FOR HUMAN NUTRITION
LA English
DT Review
DE Diabetes; Health; Food; Fructan; Fructose; Prebiotics; Oxidative stress
ID RETINOL-BINDING PROTEIN-4; INSULIN SENSITIVITY; URIC-ACID; BODY-WEIGHT;
   SWEETENED BEVERAGES; INTESTINAL BARRIER; METABOLIC SYNDROME;
   FATTY-ACIDS; STRESS; LIVER
AB Fructans are fructose-based oligo-and polysaccharides of natural origin. Fructan and fructose species are sometimes confused by the great public, although they clearly have different biochemical and physiological properties. This review discusses aspects of the use of fructose and fructans in foods in the context of human health, with possible differential effects on cellular autophagy in cells of the human body. Although there are uncertainties on the daily levels of ingested fructose to be considered harmful to human health, there is an emerging consensus on the benefits of the use of fructans in functional foods, sustaining health via direct immunomodulatory and antioxidant effects or through indirect, prebiotic mechanisms.
C1 [Di Bartolomeo, Francesca] Graz Univ Technol, Inst Biochem, A-8010 Graz, Austria.
   [Van den Ende, Wim] Katholieke Univ Leuven, Plant Mol Biol Lab, B-3001 Leuven, Belgium.
   [Van den Ende, Wim] Katholieke Univ Leuven, L FoRCe, B-3001 Leuven, Belgium.
C3 Graz University of Technology; KU Leuven; KU Leuven
RP Van den Ende, W (corresponding author), Katholieke Univ Leuven, Plant Mol Biol Lab, Kasteelpk Arenberg 31, B-3001 Leuven, Belgium.
EM wim.vandenende@bio.kuleuven.be
RI ; Van den Ende, Wim/I-6899-2013
OI Di Bartolomeo, Francesca/0000-0002-4302-0701; Van den Ende,
   Wim/0000-0003-1137-3614
FU FWO Vlaanderen
FX Wim Van den Ende is supported by funding from FWO Vlaanderen. The
   authors thank Lukasz Pawel Tarkowski for his assistance in drawing
   figures.
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NR 79
TC 25
Z9 25
U1 1
U2 67
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0921-9668
EI 1573-9104
J9 PLANT FOOD HUM NUTR
JI Plant Food Hum. Nutr.
PD SEP
PY 2015
VL 70
IS 3
BP 227
EP 237
DI 10.1007/s11130-015-0485-6
PG 11
WC Plant Sciences; Chemistry, Applied; Food Science & Technology; Nutrition
   & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Chemistry; Food Science & Technology; Nutrition &
   Dietetics
GA CP5TX
UT WOS:000359948600001
PM 25904233
DA 2025-06-11
ER

PT J
AU Belgardt, BF
   Mauer, J
   Brüning, JC
AF Belgardt, Bengt F.
   Mauer, Jan
   Bruening, Jens C.
TI Novel roles for JNK1 in metabolism
SO AGING-US
LA English
DT Article
DE JNK1; obesity; insulin resistance; CNS
ID ENDOPLASMIC-RETICULUM STRESS; N-TERMINAL KINASE; INDUCED
   INSULIN-RESISTANCE; REGULATES LIFE-SPAN; GROWTH-HORMONE;
   CAENORHABDITIS-ELEGANS; TRANSCRIPTION FACTORS; GLUCOSE-PRODUCTION;
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AB Activation of stress-kinase signaling has recently been recognized as an important pathophysiological mechanism in the development of diet-induced obesity, type 2 diabetes mellitus and other aging-related pathologies. Here, c-Jun N-terminal Kinase (JNK) 1 knockout mice have been shown to exhibit protection from diet-induced obesity, glucose intolerance, and insulin resistance. Nonetheless, the tissue-specific role of JNK1-activation in the development of the metabolic syndrome has been poorly defined so far. Recently, it was demonstrated that JNK1 signaling plays a crucial role in the central nervous system (CNS) and in the pituitary to control systemic glucose and lipid metabolism partially through regulation of hormones involved in growth and energy expenditure.
C1 [Belgardt, Bengt F.; Mauer, Jan; Bruening, Jens C.] Univ Cologne, Dept Internal Med 2, Cologne Excellence Cluster Cellular Stress Respon, Ctr Mol Med,CMMC,Inst Genet,Dept Mouse Genet & Me, D-50674 Cologne, Germany.
   [Belgardt, Bengt F.; Mauer, Jan; Bruening, Jens C.] Max Planck Inst Biol Ageing, D-50674 Cologne, Germany.
C3 University of Cologne; Max Planck Society
RP Brüning, JC (corresponding author), Univ Cologne, Dept Internal Med 2, Cologne Excellence Cluster Cellular Stress Respon, Ctr Mol Med,CMMC,Inst Genet,Dept Mouse Genet & Me, D-50674 Cologne, Germany.
EM jens.bruening@uni-koeln.de
OI Mauer, Jan/0000-0002-0189-5876; Belgardt,
   Bengt-Frederik/0000-0003-4537-9002
FU CMMC (TV2); EU [LSHM-CT-2003-503041]; Fritz Thyssen Stiftung
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FX We apologize to all colleagues whose important contribution could not be
   cited due to space limitations. This work was supported by grants from
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   Thyssen Stiftung (Az.10.04.1.153/Az.10.06.2.175) to J.C.B., the
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   (Br. 1492/7-1) to J.C.B.
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TC 28
Z9 31
U1 1
U2 4
PU IMPACT JOURNALS LLC
PI ORCHARD PARK
PA 6666 E QUAKER ST, STE 1, ORCHARD PARK, NY 14127 USA
SN 1945-4589
J9 AGING-US
JI Aging-US
PD SEP
PY 2010
VL 2
IS 9
BP 621
EP 626
DI 10.18632/aging.100192
PG 6
WC Cell Biology; Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Geriatrics & Gerontology
GA 657VR
UT WOS:000282447100012
PM 20834068
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Surma, S
   Sahebkar, A
   Urbanski, J
   Penson, PE
   Banach, M
AF Surma, Stanislaw
   Sahebkar, Amirhossein
   Urbanski, Jakub
   Penson, Peter E.
   Banach, Maciej
TI Curcumin-The Nutraceutical With Pleiotropic Effects? Which
   Cardiometabolic Subjects Might Benefit the Most?
SO FRONTIERS IN NUTRITION
LA English
DT Review
DE curcumin; cardiovascular risk; cardiovascular disease; treatment;
   prevention
ID FATTY LIVER-DISEASE; TYPE-2 DIABETES-MELLITUS; ACUTE
   MYOCARDIAL-INFARCTION; DOUBLE-BLIND; METABOLIC SYNDROME; NANO-CURCUMIN;
   ORAL BIOAVAILABILITY; CARDIOVASCULAR-DISEASES; PHYTOSOMAL CURCUMIN;
   CONTROLLED-TRIAL
AB Despite continuous advances in pharmacotherapy, atherosclerotic cardiovascular disease remains the world's leading killer. Atherosclerosis relates not only to an increased level of cholesterol, but involves the development of atherosclerotic plaques, which are formed as a result of processes including inflammation and oxidative stress. Therefore, in addition to the classical risk factors for ASCVD (such as type 2 diabetes, overweight, obesity, hypertension and metabolic syndrome), residual risk factors such as inflammation and oxidative stress should also be reduced. The most important intervention in ASCVD is prevention, which includes promoting a healthy diet based on products of natural origin. Curcumin, which is often present in the diet, has been demonstrate to confer several benefits to health. It has been shown in numerous clinical trials that curcumin exhibited anti-diabetic, lipid-lowering, antihypertensive, antioxidant and anti-inflammatory effects, as well as promoting weight loss. All this means that curcumin has a comprehensive impact on the most important risk factors of ASCVD and may be a beneficial support in the treatment of these diseases. Recently, it has also been shown that curcumin may have a beneficial effect on the course of SARS-CoV-2 infection and might be helpful in the prevention of long-COVID complications. The aim of this review is to summarize the current knowledge regarding the safety and efficacy of curcumin in the prevention and treatment of cardiometabolic diseases.
C1 [Surma, Stanislaw] Med Univ Silesia, Fac Med Sci Katowice, Katowice, Poland.
   [Surma, Stanislaw] Polish Soc Hypertens, Club Young Hypertensiologists, Gdansk, Poland.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Biotechnol Res Ctr, Mashhad, Iran.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Neurogenic Inflammat Res Ctr, Mashhad, Iran.
   [Urbanski, Jakub] NomiBiotech Corp, Zlotniki, Poland.
   [Penson, Peter E.] Liverpool John Moores Univ, Sch Pharm & Biomol Sci, Clin Pharm, Therapeut Res Grp, Liverpool, England.
   [Penson, Peter E.] Liverpool Ctr Cardiovasc Sci, Liverpool, England.
   [Banach, Maciej] Med Univ Lodz, Dept Prevent Cardiol & Lipidol, Lodz, Poland.
   [Banach, Maciej] Univ Zielona Gora, Cardiovasc Res Ctr, Zielona Gora, Poland.
   [Banach, Maciej] Polish Mothers Mem Hosp Res Inst PMMHRI, Dept Cardiol & Adult Congenital Heart Dis, Lodz, Poland.
C3 Medical University of Silesia; Mashhad University of Medical Sciences;
   Mashhad University of Medical Sciences; Liverpool John Moores
   University; Medical University Lodz; University of Zielona Gora
RP Banach, M (corresponding author), Med Univ Lodz, Dept Prevent Cardiol & Lipidol, Lodz, Poland.; Banach, M (corresponding author), Univ Zielona Gora, Cardiovasc Res Ctr, Zielona Gora, Poland.; Banach, M (corresponding author), Polish Mothers Mem Hosp Res Inst PMMHRI, Dept Cardiol & Adult Congenital Heart Dis, Lodz, Poland.
EM maciej.banach@umed.lodz.pl
RI Sahebkar, Amirhossein/B-5124-2018; Surma, Stanisław/HLX-0557-2023;
   Banach, Maciej/A-1271-2009; Penson, Peter/E-5353-2010
OI Penson, Peter/0000-0001-6763-1489; Surma, Stanislaw/0000-0001-8073-6664
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NR 141
TC 18
Z9 19
U1 0
U2 8
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD MAY 17
PY 2022
VL 9
AR 865497
DI 10.3389/fnut.2022.865497
PG 20
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 1V5NC
UT WOS:000806135100001
PM 35662932
OA gold, Green Accepted, Green Published
DA 2025-06-11
ER

PT J
AU Hosoyamada, Y
   Yamada, M
AF Hosoyamada, Yasue
   Yamada, Masako
TI Effects of Dietary Fish Oil and Apple Polyphenol on the Concentration
   Serum Lipids and Excretion of Fecal Bile Acids in Rats
SO JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY
LA English
DT Article
DE fish oil; apple pholyphenol; fecal bile acids; rat
ID POLYUNSATURATED FATTY-ACIDS; METABOLIC SYNDROME; OXIDATIVE STRESS;
   IN-VITRO; DOCOSAHEXAENOIC ACID; PANCREATIC LIPASE; TEA POLYPHENOLS;
   CHOLESTEROL; ABSORPTION; JAPANESE
AB We studied the effects of fish oil and apple polyphenol combined with a high cholesterol diet in rats, and assessed serum and liver lipids concentrations, serum oxidative stress and fecal bile acid excretion. Young male rats were fed a diet containing the control (Control), apple polyphenol (AP), fish oil (FO) or fish oil + apple polyphenol (FO +AP) for 4 wk. The control diet contained a lard component. Posterior abdominal wall fat and testicle peripheral fat weights decreased in the FO +AP group compared to the AP group. The concentration of total cholesterol in the serum and liver decreased in the FO group and the FO +AP group compared to the Control and the AP groups. The concentration of adiponectin and biological antioxidant potential in the serum increased in the FO group compared to the other groups. The diacron-reactive oxygen metabolites in serum decreased in the FO group and the FO +AP group compared to the Control and the AP groups. The bile acid excretion in feces increased in the AP group, the FO group and the FO +AP group compared to the Control group. These results suggested that the combination of fish oil and apple poly phenol in the diet improved serum and liver lipids, which should assist in the prevention and improvement of metabolic syndrome.
C1 [Hosoyamada, Yasue; Yamada, Masako] Chiba Prefectural Univ Hlth Sci, Fac Hlth Care Sci, Dept Nutr, Mihama Ku, 2-10-1 Wakaba, Chiba, Chiba 2610014, Japan.
RP Hosoyamada, Y (corresponding author), Chiba Prefectural Univ Hlth Sci, Fac Hlth Care Sci, Dept Nutr, Mihama Ku, 2-10-1 Wakaba, Chiba, Chiba 2610014, Japan.
EM yasue.hosoyamada@cpuhs.ac.jp
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NR 35
TC 13
Z9 15
U1 0
U2 13
PU CENTER ACADEMIC PUBL JAPAN
PI TOKYO
PA 2-4-16 YAYOI, BUNKYO-KU, TOKYO, 113-0032, JAPAN
SN 0301-4800
EI 1881-7742
J9 J NUTR SCI VITAMINOL
JI J. Nutr. Sci. Vitaminol.
PD FEB
PY 2017
VL 63
IS 1
BP 21
EP 27
PG 7
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA EN0TW
UT WOS:000395724400004
PM 28367922
OA gold
DA 2025-06-11
ER

PT J
AU Cho, KI
   Kim, BH
   Je, HG
   Jang, JS
   Park, YH
AF Cho, Kyoung Im
   Kim, Bo Hyun
   Je, Hyung Gon
   Jang, Jae Sik
   Park, Yong Hyun
TI Gender-Specific Associations between Socioeconomic Status and
   Psychological Factors and Metabolic Syndrome in the Korean Population:
   Findings from the 2013 Korean National Health and Nutrition Examination
   Survey
SO BIOMED RESEARCH INTERNATIONAL
LA English
DT Article
ID CARDIOVASCULAR-DISEASE; PREVALENCE; OBESITY; ADULTS; SEX
AB We aimed to assess the gender-specific associations between psychological factors and socioeconomic status (SES) and metabolic syndrome (MetS) in Korean adults. We examined 4,689 Korean adults aged 20-79 years who participated in the 2013 Korean National Health Examination and Nutrition Survey. With regard to SES, occupation status (none, manual, and nonmanual), marital status (single, married, divorced, and widowed), and psychological factors (detection of stress, depressive symptoms, and suicidal thoughts) were determined via questionnaires. Compared with married men, single and divorced men exhibited ORs (95% confidence interval [CIs]) for MetS of 0.45 (0.31-0.65) and 1.61 (1.02-2.55), respectively, after adjusting for covariates. However, this association was not significant in women. Compared with those in the lowest household income group and least educated group in women, the ORs for MetS in the highest income group and the most educated group were 0.63 (CI 0.46-0.86) and 0.46 (CI 0.32-0.67), respectively. Suicidal thoughts in men (OR 1.64, CI 1.03-2.61) and perceived stress in women (OR 1.26, CI 1.01-1.59) were associated with MetS. In this study, MetS has gender-specific associations with lower SES and psychological factors. Thus, gender-specific public health interventions based on SES and psychological factors are needed to prevent and treat MetS and reduce additional cardiovascular disease risk.
C1 [Cho, Kyoung Im] Kosin Univ, Sch Med, Dept Internal Med, 34 Amnam Dong, Busan 602702, South Korea.
   [Kim, Bo Hyun] Pusan Natl Univ Hosp & Biomed Res Inst, Dept Internal Med, 179 Gudeok Ro, Busan 602739, South Korea.
   [Je, Hyung Gon] Pusan Natl Univ, Yangsan Hosp, Res Inst Convergence Biomed Sci & Technol, Dept Cardiovasc & Thorac Surg, Yangsan 626770, South Korea.
   [Jang, Jae Sik] Univ Inje, Coll Med, Busan Paik Hosp, Dept Internal Med, Busan 614735, South Korea.
   [Park, Yong Hyun] Pusan Natl Univ, Yangsan Hosp, Dept Internal Med, Yangsan 626770, South Korea.
C3 Pusan National University; Pusan National University Hospital; Inje
   University; Pusan National University; Pusan National University
   Hospital
RP Kim, BH (corresponding author), Pusan Natl Univ Hosp & Biomed Res Inst, Dept Internal Med, 179 Gudeok Ro, Busan 602739, South Korea.
EM pons71@hanmail.net
RI Kim, Yun Hak/ABF-3331-2021; Cho, Young-Seok/J-5670-2012; Jang,
   Jae-Sik/B-4379-2015
OI Kim, Bo Hyun/0000-0001-9632-9457
CR Al-Daghri NM, 2014, BMC CARDIOVASC DISOR, V14, DOI [10.1186/1471-2458-14-391, 10.1186/1471-2261-14-51]
   Booth SL, 2001, NUTR REV, V59, pS21, DOI 10.1111/j.1753-4887.2001.tb06983.x
   Buckland G, 2008, PUBLIC HEALTH NUTR, V11, P1372, DOI 10.1017/S1368980008003492
   Cleeman JI, 2001, JAMA-J AM MED ASSOC, V285, P2486, DOI 10.1001/jama.285.19.2486
   Gurka MJ, 2014, METABOLISM, V63, P218, DOI 10.1016/j.metabol.2013.10.006
   Ha KH, 2015, ENDOCRINOL METAB, V30, P142, DOI 10.3803/EnM.2015.30.2.142
   Hosseinpour-Niazi S, 2014, INT J ENDOCRINOL MET, V12, DOI 10.5812/ijem.18980
   Joh HK, 2013, OBESITY FACTS, V6, P17, DOI 10.1159/000346805
   Lakka HM, 2002, JAMA-J AM MED ASSOC, V288, P2709, DOI 10.1001/jama.288.21.2709
   Lee SY, 2007, DIABETES RES CLIN PR, V75, P72, DOI 10.1016/j.diabres.2006.04.013
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   Pan A, 2012, DIABETES CARE, V35, P1171, DOI 10.2337/dc11-2055
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   Regidor E, 2004, EUR J CLIN NUTR, V58, P488, DOI 10.1038/sj.ejcn.1601835
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   Walker SE, 2012, NUTR METAB CARDIOVAS, V22, P141, DOI 10.1016/j.numecd.2010.05.006
   Wilson PWF, 2005, CIRCULATION, V112, P3066, DOI 10.1161/CIRCULATIONAHA.105.539528
NR 24
TC 25
Z9 27
U1 1
U2 4
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2314-6133
EI 2314-6141
J9 BIOMED RES INT
JI Biomed Res. Int.
PY 2016
VL 2016
AR 3973197
DI 10.1155/2016/3973197
PG 8
WC Biotechnology & Applied Microbiology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Biotechnology & Applied Microbiology; Research & Experimental Medicine
GA EF6MA
UT WOS:000390443900001
PM 28050556
OA hybrid, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Arpaci, D
   Celik, SK
   Can, M
   Ermis, E
   Kuzu, F
   Kokturk, F
   Hamamcioglu, AC
   Dursun, A
   Bayraktaroglu, T
AF Arpaci, Dilek
   Celik, Sevim Karakas
   Can, Murat
   Ermis, Esra
   Kuzu, Fatih
   Kokturk, Furuzan
   Hamamcioglu, Ayse Ceylan
   Dursun, Ahmet
   Bayraktaroglu, Taner
TI Serum paraoxonase level and paraoxonase polymorphism in patients with
   acromegaly
SO REDOX REPORT
LA English
DT Article
DE Acromegaly; Paraoxonase; Polymorphism
ID CORONARY-ARTERY-DISEASE; GROWTH-FACTOR-I; Q192R POLYMORPHISM;
   RISK-FACTORS; DENSITY-LIPOPROTEIN; LIPID-PEROXIDATION; OXIDATIVE STRESS;
   DIABETES-MELLITUS; GENE; ATHEROSCLEROSIS
AB Background: Acromegalic patients have increased cardiometabolic risk factors due to an elevation of growth hormone (GH) levels. Human serum paraoxonase (PON), a high-density lipoprotein (HDL)-related enzyme, is one of the major bioscavengers and decreases the oxidation of low-density lipoprotein (LDL), a key regulator in the pathogenesis of atherosclerosis. In this study, we investigated a potential relationship between serum PON levels or PON polymorphisms and acromegaly.
   Methods: A total of 48 acromegalic patients and 44 healthy controls were included in this study. Serum GH levels, insulin-like growth factor-1 levels and lipid profiles were measured. Serum PON levels, as well as PON 1 L55M and Q192R gene polymorphisms, were examined.
   Results: No significant differences were found in terms of age, gender, presence of diabetes, serum LDL cholesterol (LDL-C), HDL-C, or triglyceride levels between the case and control groups (P > 0.05). A statistically significant difference was found in serum PON levels between the cases and controls (P = 0.007). The median serum PON level was 101 +/- 63.36 U/l in the case group and 63 +/- 60.50 U/l in the control group. There was a significant correlation between serum PON levels and IGF-1 levels (P = 0.004, r = 0.319); however, no significant differences were found in PON1 L55M and PON Q192R polymorphisms between the patients and controls (P = 0.607 and P = 0.308, respectively). In addition, no significant differences were found in serum PON levels in acromegalic patients who were and were not in remission (P = 0.385), nor between those with PON1 L55M and Q192R polymorphisms (P = 0.161 and P = 0.336, respectively).
   Conclusions: Elevated serum PON levels were detected in acromegalic patients, independently of their remission status. This suggests protective effects for cardiometabolic risk parameters.
C1 [Arpaci, Dilek; Kuzu, Fatih; Bayraktaroglu, Taner] Bulent Ecevit Univ, Dept Endocrinol & Metab, Fac Med, Kozlu, Zonguldak, Turkey.
   [Celik, Sevim Karakas] Bulent Ecevit Univ, Grad Sch Nat & Appl Sci, Dept Biol, Zonguldak, Turkey.
   [Can, Murat] Bulent Ecevit Univ, Dept Biochem, Fac Med, Zonguldak, Turkey.
   [Ermis, Esra; Dursun, Ahmet] Bulent Ecevit Univ, Fac Arts & Sci, Dept Mol Biol & Genet, Zonguldak, Turkey.
   [Kokturk, Furuzan] Bulent Ecevit Univ, Dept Biostat, Fac Med, Zonguldak, Turkey.
   [Hamamcioglu, Ayse Ceylan] Bulent Ecevit Univ, Fac Chem, Zonguldak, Turkey.
C3 Zonguldak Bulent Ecevit University; Zonguldak Bulent Ecevit University;
   Zonguldak Bulent Ecevit University; Zonguldak Bulent Ecevit University;
   Zonguldak Bulent Ecevit University; Zonguldak Bulent Ecevit University
RP Arpaci, D (corresponding author), Bulent Ecevit Univ, Dept Endocrinol & Metab, Fac Med, Kozlu, Zonguldak, Turkey.
EM drarpaci@gmail.com
RI Bayraktaroglu, Taner/Y-8182-2019; Hamamcioglu, Ayse
   Ceylan/AAG-4209-2019; Dursun, Ahmet/HGU-7580-2022; CAN,
   Murat/S-6630-2016; Ermis Akyuz, Esra/MGA-6180-2025; kuzu,
   Fatih/R-6801-2017; KARAKAS CELIK, Sevim/C-3773-2018
OI KARAKAS CELIK, Sevim/0000-0003-0505-7850; DURSUN,
   AHMET/0000-0002-7625-837X; Karakaya, Dilek/0000-0002-3603-5198; Ermis
   Akyuz, Esra/0000-0001-6233-2420
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NR 41
TC 1
Z9 1
U1 0
U2 5
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1351-0002
EI 1743-2928
J9 REDOX REP
JI Redox Rep.
PY 2016
VL 21
IS 6
BP 281
EP 286
DI 10.1080/13510002.2015.1133036
PG 6
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA DX7AU
UT WOS:000384538900006
PM 26863932
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Indriyati, T
   Adisasmita, AC
   Nadjib, M
   Subekti, I
   Hatma, RD
   Kosen, S
   Riyadina, W
   Purnamasari, T
AF Indriyati, Titi
   Adisasmita, Asri C.
   Nadjib, Mardiati
   Subekti, Imam
   Hatma, Ratna Djuwita
   Kosen, Soewarta
   Riyadina, Woro
   Purnamasari, Telly
TI The role of changes in metabolic syndrome status on health-related
   quality of life in Bogor City, West Java, Indonesia: A cross-sectional
   study
SO BELITUNG NURSING JOURNAL
LA English
DT Article
DE Indonesia; comorbidity; effect modification; dose-response relationship;
   health-related quality of life; metabolic syndrome; cardiovascular
   diseases
ID RISK; ADULTS
AB Background: Metabolic syndrome (MetS) is a cluster of chronic conditions, including central obesity, hypertension, impaired glucose metabolism, and dyslipidemia (low HDL, high LDL, and triglycerides). A diagnosis of MetS is made when three or more of these symptoms are present. If left unmanaged, MetS can lead to serious health complications such as cardiovascular disease and type 2 diabetes. Over time, individuals with MetS may experience a decline in their health-related quality of life (HRQoL), especially due to its chronic nature. Objective: This study aimed to evaluate the effects of changes in MetS status on HRQoL. Methods: This study employed a cross-sectional design. Secondary data from the cohort study of Non-Communicable Disease (NCD) risk factors, conducted by the Health Research and Development Agency of the Ministry of Health of the Republic of Indonesia in Bogor City, was used. Data from four follow-up periods (2011/2012 to 2017/2018) were analyzed. A total of 874 respondents were selected via total sampling based on inclusion and exclusion criteria. Data were collected in 2021, which included measures of knowledge, health check-ups, and HRQoL using the SF-36 questionnaire. Statistical analyses, including chi-square tests, t-tests, and multiple regression analyses, were conducted to examine the associations between MetS status and HRQoL. Results: Descriptive analysis revealed that 19% (171 participants) had worsened MetS status, while 80.4% (703 participants) showed improvement. Chi-Square analysis found that respondents with worsening MetS status were 1.6 times more likely to experience poor HRQoL in the physical dimension (95% CI = 1.1-2.3), but no significant effect was found for the mental dimension (PR = 1.1, 95% CI = 0.8-1.6). Multiple logistic regression analysis revealed that comorbidities interacted with worsening MetS status to significantly affect HRQoL in the physical dimension. The adjusted prevalence ratios (PR) were 27.5 (95% CI = 10.3-73.2) for those with comorbidities and 9.2 (95% CI = 5.7-15.0) for those without comorbidities, after controlling for age, mental health, BMI changes, routine health checks, and knowledge. Conclusion: Changes in MetS status towards worsening have a significant negative effect on HRQoL, particularly in the physical dimension. The presence of comorbidities in individuals with worsening MetS status greatly increases the risk of poor HRQoL. Healthcare professionals and nurses should consider the interaction between MetS and comorbidities in patient management. Nurses are encouraged to monitor HRQoL in patients with MetS, promote education on managing comorbidities, and collaborate across disciplines to enhance patient care and intervention programs aimed at improving HRQoL.
C1 [Indriyati, Titi] Univ Mohammad Husni Thamrin Jakarta, Fac Hlth, Jakarta, Indonesia.
   [Adisasmita, Asri C.; Nadjib, Mardiati; Hatma, Ratna Djuwita; Kosen, Soewarta] Univ Indonesia, Fac Publ Hlth, Depok, Indonesia.
   [Subekti, Imam] Cipto Mangunkusumo Natl Cent Gen Hosp, Jakarta, Indonesia.
   [Riyadina, Woro; Purnamasari, Telly] Natl Res & Innovat Agcy BRIN, Jakarta, Indonesia.
C3 University of Indonesia; National Research & Innovation Agency of
   Indonesia (BRIN)
RP Indriyati, T (corresponding author), Univ Mohammad Husni Thamrin Jakarta, Fac Hlth, Jakarta, Indonesia.
EM indriyati2901@gmail.com
RI Riyadina, Woro/IQW-6286-2023
FU Epidemiology Study Program, Faculty of Public Health, Universitas
   Indonesia
FX The authors would like to thank the Head of the Health Research and
   Development Agency of the Indonesian Ministry of Health, the Principal
   Investigator of the NCD Cohort Study in Bogor City, the enumerator team,
   health cadres in the study area, and all participants who voluntarily
   provided their information. They also greatly acknowledge the
   Epidemiology Study Program, Faculty of Public Health, Universitas
   Indonesia, and all leaders at Universitas Mohammad Husni Thamrin,
   Jakarta, for supporting this study.
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NR 46
TC 0
Z9 0
U1 0
U2 0
PU BELITUNG RAYA FOUNDATION
PI BELITUNG
PA RT 06 RW 02, URISAN JAYA, PADANG, BELITUNG TIMUR, MANGGAR, BANGKA,
   BELITUNG, INDONESIA
SN 2528-181X
EI 2477-4073
J9 BELITUNG NURS J
JI Belitung Nurs. J.
PD MAR-APR
PY 2025
VL 11
IS 2
BP 172
EP 185
DI 10.33546/bnj.3543
PG 14
WC Nursing
WE Emerging Sources Citation Index (ESCI)
SC Nursing
GA 1SE9P
UT WOS:001472403200001
PM 40256385
DA 2025-06-11
ER

PT J
AU Correll, CU
AF Correll, Christoph U.
TI Balancing efficacy and safety in treatment with antipsychotics
SO CNS SPECTRUMS
LA English
DT Review
ID CORONARY-HEART-DISEASE; CARDIOVASCULAR RISK-FACTORS; CATIE SCHIZOPHRENIA
   TRIAL; PLACEBO-CONTROLLED TRIAL; DOUBLE-BLIND; METABOLIC SYNDROME;
   ATYPICAL ANTIPSYCHOTICS; BIPOLAR-DISORDER; SCHIZOAFFECTIVE DISORDER;
   WEIGHT-GAIN
AB Balancing efficacy with tolerability and safety of prescribed treatments is critical to optimizing antipsychotic treatment outcomes in the mentally ill. Symptom control, symptom remission, and functional recovery are only realistic goals when treatments are both effective and well tolerated. The consideration of predictable differences in antipsychotic adverse-effect profiles is central to successful illness management. Minimizing adverse effects on alertness, motivation, cognition, sexual/reproductive functioning, and physical health enhances mental health outcomes, partly through improving treatment adherence. Neuroendocrine and metabolic side effects of antipsychotics for cardiovascular morbidity and mortality need to be addressed proactively and aggressively. In view of the widespread lack of primary care engagement and the adverse effects of psychotropic medications on cardiovascular health, psychiatric care providers should function as key facilitators of an integrated mental and physical health management approach. In addition to psychoeducation and healthy lifestyle counseling, clinicians can improve psychiatric and physical health by selecting medications carefully, routinely screening and monitoring for reversible cardiovascular risk factors, and playing an active role in the prevention and interdisciplinary management of cardiovascular risk factors and medical illness in the vulnerable mentally ill.
C1 Zucker Hillside Hosp Queens, Recognit & Prevent Program, New York, NY USA.
   Albert Einstein Coll Med, Bronx, NY 10467 USA.
C3 Northwell Health; Montefiore Medical Center; Albert Einstein College of
   Medicine; Yeshiva University
RP Correll, CU (corresponding author), Zucker Hillside Hosp Queens, Recognit & Prevent Program, New York, NY USA.
EM ccorrell@lii.edu
RI Correll, Christoph/D-3530-2011
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NR 107
TC 67
Z9 69
U1 0
U2 19
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
SN 1092-8529
EI 2165-6509
J9 CNS SPECTRUMS
JI CNS Spectr.
PD OCT
PY 2007
VL 12
IS 10
SU 17
BP 12
EP +
DI 10.1017/S1092852900026298
PG 10
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Psychiatry
GA 229SZ
UT WOS:000250825900003
PM 17934385
DA 2025-06-11
ER

PT J
AU Emik-Ozdemir, B
   Tunc-Ata, M
   Ozdemir, Y
   Kilic-Erkek, O
   Senol, H
   Kucukatay, V
   Bor-Kucukatay, M
AF Emik-Ozdemir, Busra
   Tunc-Ata, Melek
   Ozdemir, Yasin
   Kilic-Erkek, Ozgen
   Senol, Hande
   Kucukatay, Vural
   Bor-Kucukatay, Melek
TI The effects of swimming exercise and detraining on hemorheological
   parameters and oxidative stress in rats with metabolic syndrome
SO NUTRITION CLINIQUE ET METABOLISME
LA English
DT Article
DE Monosodium glutamate (MSG); Exercise training; Detraining; Antioxidant
   status; Whole blood viscosity (WBV)
ID REGULAR EXERCISE; BLOOD-VISCOSITY; OBESE; ASSOCIATION; INTENSITY;
   GLUCOSE; DEFENSE; PLASMA
AB Background. - Moderate-intensity aerobic exercise training with high frequency is recommended in metabolic syndrome (MetS). We aimed to investigate the effects of swimming and subsequent detraining on hemorheology and oxidative stress in MetS.Material and methods. - A total of 80 rats were used. MetS was induced by a 4 mg/g monosodium glutamate (MSG) injection to rats on days 0-10, every other day. Swimming exercise training was applied 30 minutes, 3 days/week, with a 5% body weight load, for 18 weeks. Detraining was applied for 8 weeks. Erythrocyte deformability was measured with an ektacytometer, whole blood viscosity (WBV) by a cone-plate viscometer, total oxidant-antioxidant capacity (TOS-TAS) were measured by commercial kits.Results. - Exercise resulted in an increment of HDL in rats with MetS, which was not reversed by detraining. Swimming decreased HOMA-IR score in MetS. Detraining caused an increase in WBV in healthy rats. The exercise applied resulted in an increase in TAS in both healthy and MetS rats.Conclusion. - We suggest that swimming may be beneficial in MetS and may contribute positively to the prevention of the development of possible complications by increasing TAS. Since some of the gains of exercise training are reversed by detraining, lifetime exercise training may be recommended.& COPY; 2023 Societe francophone nutrition clinique et metabolisme (SFNCM). Published by Elsevier Masson SAS. All rights reserved.
C1 [Emik-Ozdemir, Busra] Bigad State Hosp, Phys Therapy Unit, TR-10440 Bigadic, Balikesir, Turkiye.
   [Tunc-Ata, Melek; Kilic-Erkek, Ozgen; Kucukatay, Vural; Bor-Kucukatay, Melek] Pamukkale Univ, Fac Med, Dept Physiol, TR-20070 Kinikli, Denizli, Turkiye.
   [Ozdemir, Yasin] Tercih Common Hlth & Safety Unit, TR-10100 Altieylul, Balikesir, Turkiye.
   [Senol, Hande] Pamukkale Univ, Fac Med, Dept Biostat, TR-20070 Kinikli, Denizli, Turkiye.
C3 Bigadic State Hospital; Pamukkale University; Pamukkale University
RP Bor-Kucukatay, M (corresponding author), Pamukkale Univ, Fac Med, Dept Physiol, TR-20070 Kinikli, Denizli, Turkiye.
EM mbor@pau.edu.tr
RI Kucukatay, Vural/ABI-6427-2020; Kilic-Erkek, Ozgen/AAA-1237-2022
FU PAU Scientific Research Projects Coordination Unit [2018SABE033]
FX This work was supported by the PAU Scientific Research Projects
   Coordination Unit (Project no: 2018SABE033) .
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NR 45
TC 0
Z9 0
U1 0
U2 5
PU MASSON EDITEUR
PI MOULINEAUX CEDEX 9
PA 21 STREET CAMILLE DESMOULINS, ISSY, 92789 MOULINEAUX CEDEX 9, FRANCE
SN 0985-0562
EI 1768-3092
J9 NUTR CLIN METAB
JI Nutr. Clin. Metab.
PD MAY
PY 2023
VL 37
IS 2
BP 94
EP 100
DI 10.1016/j.nupar.2023.01.003
EA MAY 2023
PG 7
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA M0FG0
UT WOS:001026940300001
DA 2025-06-11
ER

PT J
AU Pin, NT
AF Pin, Ng Tze
TI Cognitive Health of Older Persons in Longitudinal Ageing Cohort Studies
SO SAINS MALAYSIANA
LA English
DT Article
DE Aging; cognitive function; dementia; older adult; risk factor
ID ALZHEIMERS-DISEASE; BLOOD-PRESSURE; LEISURE ACTIVITIES; RISK-FACTORS;
   METABOLIC SYNDROME; TEA CONSUMPTION; MARITAL-STATUS; LATER LIFE;
   DEMENTIA; DECLINE
AB Dementia poses a major global burden of care to society and health systems in ageing populations. The majority (over 60%) of persons with dementia in the world are found in Asia and developing countries with rapid rates of population ageing. Improving and maintaining the cognitive health of older persons is vital to national strategies for dementia prevention. Increasing numbers of population-based ageing cohort studies in the past decade have provided a better understanding of the factors that contribute to cognitive function and decline in old age. The roles of major demographic, psychosocial, lifestyle, behavioral and cardiovascular risk factors contributing to cognitive health were discussed using examples from the Singapore Longitudinal Ageing Studies. They include socio-demographic factors, particularly education and marital status, leisure time activity such as physical activity, social engagement and mental activities, psychological factors such as depression, cardiovascular and metabolic risk factors: obesity, diabetes, hypertension and dyslipidemia, and the metabolic syndrome, under-nutrition, low albumin, low hemoglobin, nutritional factors such as blood folate, B12 and homocysteine, omega-3 poly-unsaturated fatty acids, tea drinking and curcumin-rich turmeric in curry meals. These factors are found to be associated variously with cognitive functions (memory and learning, language, visuospatial, attention and information processing speed), rates of cognitive impairment and cognitive decline, or increased risk of developing MCI and progression to dementia.
C1 [Pin, Ng Tze] Natl Univ Singapore, Yong Yoo Lin Sch Med, Res Programme, Dept Psychol Med & Gerontol, 21 Lower Kent Ridge Rd, Singapore 119077, Singapore.
C3 National University of Singapore
RP Pin, NT (corresponding author), Natl Univ Singapore, Yong Yoo Lin Sch Med, Res Programme, Dept Psychol Med & Gerontol, 21 Lower Kent Ridge Rd, Singapore 119077, Singapore.
EM pcmngtp@nus.edu.sg
FU Biomedical Research Council, Agency for Science, Technology and Research
   [03/1/21/17/214]; National Medical Research Council [08/1/21/19/567];
   National Medical Research Council (NMRC/CG/NUHCS); Geylang East Home for
   the Aged; Presbyterian Community Services; Thye Hua Kwan Moral Society
   (Moral Neighbourhood Links); Yuhua Neighbourhood Link; Henderson Senior
   Citizens' Home; NTUC Eldercare Co-op Ltd; Thong Kheng Seniors Activity
   Centre (Queenstown Centre); Redhill Moral Seniors Activity Centre
FX The study was supported by research grant funding from the Biomedical
   Research Council, Agency for Science, Technology and Research
   (03/1/21/17/214) and National Medical Research Council (08/1/21/19/567
   and NMRC/CG/NUHCS/2010). The authors would like to thank the following
   voluntary welfare organizations for their support of the Singapore
   Longitudinal Ageing Studies: Geylang East Home for the Aged,
   Presbyterian Community Services, Thye Hua Kwan Moral Society (Moral
   Neighbourhood Links), Yuhua Neighbourhood Link, Henderson Senior
   Citizens' Home, NTUC Eldercare Co-op Ltd, Thong Kheng Seniors Activity
   Centre (Queenstown Centre) and Redhill Moral Seniors Activity Centre.
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NR 51
TC 2
Z9 2
U1 0
U2 24
PU UNIV KEBANGSAAN MALAYSIA
PI SELANGOR
PA FACULTY SCIENCE & TECHNOLOGY, BANGI, SELANGOR, 43600, MALAYSIA
SN 0126-6039
J9 SAINS MALAYS
JI Sains Malays.
PD SEP
PY 2016
VL 45
IS 9
BP 1351
EP 1355
PG 5
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA EA4PF
UT WOS:000386594400009
DA 2025-06-11
ER

PT J
AU Wüst, S
   Entringer, S
   Federenko, IS
   Schlotz, W
   Hellhammer, DH
AF Wüst, S
   Entringer, S
   Federenko, IS
   Schlotz, W
   Hellhammer, DH
TI Birth weight is associated with salivary cortisol responses to
   psychosocial. stress in adult life
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE hypothalamus-pituitary-adrenal axis; prenatal stress; birth weight;
   length of gestation; TSST
ID PITUITARY-ADRENAL AXIS; FETAL-ORIGINS HYPOTHESIS; PRENATAL STRESS;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; GESTATIONAL-AGE; HEART-DISEASE;
   HPA AXIS; PREGNANCY; SECRETION
AB Fetal programming of the hypothalamus-pituitary-adrenal (HPA) axis was proposed as one mechanism underlying the link between prenatal stress, adverse birth outcomes (particularly tow birth weight) and an enhanced vulnerability for several diseases later in life. In recent studies, birth weight was significantly related to basal cortisol levels as well as to cortisol responses to pharmacological stimulation.
   In order to investigate the association between cortisol responses to psychological challenge, birth weight and length of gestation, 106 young healthy mates were exposed to the 'Trier Social Stress Test'. Salivary cortisol responses to the stress exposure were significantly and inversely related to the subjects' birth weight, white the analysis of the impact of gestational age yielded inconsistent results.
   This finding is consistent with the concept of fetal programming of the HPA axis and provides the first preliminary evidence for an association between birth weight and adrenocortical responses to psychosocial stress. As the investigated subjects were twins, possible implications of this sample characteristic for the present findings are discussed. (c) 2005 Elsevier Ltd. All rights reserved.
C1 Univ Trier, Dept Psychobiol, D-54290 Trier, Germany.
C3 Universitat Trier
RP Univ Trier, Dept Psychobiol, Johanniterufer 15, D-54290 Trier, Germany.
EM wuest@uni-trier.de
RI Schlotz, Wolff/AAI-9549-2020; Hellhammer, Dirk/F-1888-2013; Entringer,
   Sonja/ABB-9405-2020; Yim, Ilona/D-4331-2011
OI Entringer, Sonja/0000-0002-9926-7076; Wust, Stefan/0000-0002-2315-8949;
   Schlotz, Wolff/0000-0003-2356-7766
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NR 50
TC 163
Z9 173
U1 0
U2 15
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD JUL
PY 2005
VL 30
IS 6
BP 591
EP 598
DI 10.1016/j.psyneuen.2005.01.008
PG 8
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA 917XN
UT WOS:000228502700009
PM 15808929
DA 2025-06-11
ER

PT J
AU Kazukauskiene, N
   Podlipskyte, A
   Varoneckas, G
   Mickuviene, N
AF Kazukauskiene, Nijole
   Podlipskyte, Aurelija
   Varoneckas, Giedrius
   Mickuviene, Narseta
TI Health-related quality of life and insulin resistance over a 10-year
   follow-up
SO SCIENTIFIC REPORTS
LA English
DT Article
ID METABOLIC SYNDROME; MENTAL-HEALTH; HYPERINSULINEMIA; STATEMENT
AB The aim of the study was to investigate the association between insulin resistance (IR) and health-related quality of life (HRQoL) among citizens of Palanga in a 10-year follow-up. A randomized epidemiological study was performed with 835 subjects. The following data were examined using questionnaires: sociodemographic characteristics, behavioural factors, HRQoL and self-perceived health. Fasting blood samples were drawn from all participants, and biochemical tests were performed for glucose and insulin. IR was evaluated by the homeostasis model assessment of IR (HOMA-IR). In subjects with IR, after adjusting for various factors, logistic regression analysis showed that within 10 years, there was a significantly higher chance of deteriorating HRQoL in the areas of physical functioning (odds ratio [OR] = 1.15, p < 0.001), emotional role limitations (OR = 1.07, p = 0.034), social functioning (OR = 1.26, p = 0.004), pain (OR = 1.09, p = 0.005) and general health perception (OR = 1.07, p = 0.022). People with IR have a worse HRQoL, and as they age, they are significantly more likely to have a deterioration in their HRQoL than people without IR in the areas of physical functioning, emotional role limitations, social functioning, pain and general health perception.
C1 [Kazukauskiene, Nijole; Podlipskyte, Aurelija; Varoneckas, Giedrius; Mickuviene, Narseta] Lithuanian Univ Hlth Sci, Neurosci Inst, Lab Behav Med, Vyduno Al 4, LT-00135 Palanga, Lithuania.
C3 Lithuanian University of Health Sciences
RP Kazukauskiene, N (corresponding author), Lithuanian Univ Hlth Sci, Neurosci Inst, Lab Behav Med, Vyduno Al 4, LT-00135 Palanga, Lithuania.
EM nijole.kazukauskiene@lsmuni.lt
OI Podlipskyte, Aurelija/0000-0003-1412-6168; Varoneckas,
   Giedrius/0000-0001-8073-4335
FU Research Council of Lithuania [S-SEN-20-13]
FX This research is funded by a grant (No. S-SEN-20-13) from the Research
   Council of Lithuania.
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NR 35
TC 8
Z9 9
U1 0
U2 8
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD DEC 21
PY 2021
VL 11
IS 1
AR 24294
DI 10.1038/s41598-021-03791-x
PG 8
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Science & Technology - Other Topics
GA XR9VH
UT WOS:000732567600081
PM 34934126
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Hetrick, S
   Alvarez-Jiménez, M
   Parker, A
   Hughes, F
   Willet, M
   Morley, K
   Fraser, R
   McGorry, P
   Thompson, A
AF Hetrick, Sarah
   Alvarez-Jimenez, Mario
   Parker, Alexandra
   Hughes, Frank
   Willet, Michaela
   Morley, Katherine
   Fraser, Richard
   McGorry, Patrick
   Thompson, Andrew
TI Promoting physical health in youth mental health services: ensuring
   routine monitoring of weight and metabolic indices in a first episode
   psychosis clinic
SO AUSTRALASIAN PSYCHIATRY
LA English
DT Article
DE adverse effects; evidence based practice; first episode psychosis;
   knowledge transfer; metabolic syndrome
ID RISK-ASSESSMENT; ANTIPSYCHOTICS; IMPLEMENTATION; DISORDERS; CARE
AB Objective: Clinicians are increasingly being asked to implement guideline recommendations into their practice, but are given little practical guidance on this complex task. In this paper we outline a promising theory-driven approach we took to implementing guideline recommendations about routine monitoring of weight gain and metabolic disturbance in our first-episode psychosis clinic. While there is significant psychological and physical morbidity associated with weight gain and metabolic disturbance, routine monitoring was not being undertaken according to guideline recommendations. We examined the factors that make it difficult to undertake routine monitoring by interviewing psychiatrists. This barrier analysis allowed us to develop and introduce feasible and acceptable strategies to address these barriers, increasing the likelihood that routine monitoring would take place.
   Conclusion: This paper advocates for undertaking an analysis of the barriers clinicians face to undertaking evidence-based practice in order to develop more sophisticated approaches to address areas where clinical practice and evidence are divergent. Such an approach is more likely to ensure that measures to improve practice are successful, are meaningful for the clinicians involved, and become imbedded in the clinical practice of the service.
C1 [Hetrick, Sarah; Parker, Alexandra; Willet, Michaela] Univ Melbourne, Ctr Youth Mental Hlth, Orygen Youth Hlth Res Centre, Ctr Excellence, Melbourne, Vic, Australia.
   [Hetrick, Sarah; Parker, Alexandra; Willet, Michaela; McGorry, Patrick] Natl Youth Mental Hlth Fdn, Melbourne, Vic, Australia.
   [Hughes, Frank] EPPIC Clin Orygen Youth Hlth, Melbourne, Vic, Australia.
   [Morley, Katherine] Univ Melbourne, Ctr Youth Mental Hlth, Orygen Youth Hlth Res Ctr, Appl Genet Unit, Melbourne, Vic, Australia.
   [Morley, Katherine] Univ Melbourne, Sch Populat Hlth, Ctr Mol Environm Genet & Analyt Epidemiol, Melbourne, Vic, Australia.
   [Fraser, Richard] Univ Melbourne, Ctr Youth Mental Hlth, Youth Hlth Res Ctr, Melbourne, Vic, Australia.
   [McGorry, Patrick; Thompson, Andrew] Orygen Youth Hlth, Melbourne, Vic, Australia.
C3 University of Melbourne; Orygen, The National Centre of Excellence in
   Youth Mental Health; Orygen, The National Centre of Excellence in Youth
   Mental Health; University of Melbourne; University of Melbourne; Orygen,
   The National Centre of Excellence in Youth Mental Health; University of
   Melbourne; Orygen, The National Centre of Excellence in Youth Mental
   Health
RP Hetrick, S (corresponding author), Univ Melbourne, Ctr Youth Mental Hlth, Orygen Youth Hlth Res Centre, Ctr Excellence, Locked Bag 10, Parkville, Vic 3052, Australia.
EM shetrick@unimelb.edu.au
RI Parker, Alexandra/AER-0997-2022; Hetrick, Sarah/AAT-1277-2020; McGorry,
   Patrick/O-4115-2019; Thompson, Andrew/F-3153-2012; Alvarez-Jimenez,
   Mario/G-4691-2013; Morley, Katherine/A-2986-2011
OI McGorry, Patrick/0000-0002-3789-6168; Parker,
   Alexandra/0000-0002-2398-6306; Thompson, Andrew/0000-0002-0567-6013;
   Alvarez-Jimenez, Mario/0000-0002-3535-9086; Morley,
   Katherine/0000-0002-2725-5535
CR Alvarez-Jiménez M, 2008, CNS DRUGS, V22, P547, DOI 10.2165/00023210-200822070-00002
   [Anonymous], MENTAL HLTH AUSTR CO
   Bick P, 2007, AUSTRALAS PSYCHIATRY, V15, P465, DOI 10.1080/10398560701689186
   Braun V., 2006, Qualitative Research in Psychology, V3, P77, DOI [10.1191/1478088706oa, DOI 10.1191/1478088706OA, DOI 10.1191/1478088706QP063OA]
   Dunbar L, 2010, AUSTRALAS PSYCHIATRY, V18, P322, DOI 10.3109/10398561003692571
   Dunbar L, 2010, AUSTRALAS PSYCHIATRY, V18, P318, DOI 10.3109/10398561003692563
   Grimshaw JM, 2004, HEALTH TECHNOL ASSES, V8, P1, DOI 10.3310/hta8060
   Grol R, 2001, MED CARE, V39, pII46
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   Hennekens CH, 2007, J CLIN PSYCHIAT, V68, P4
   Jamtvedt G, 2006, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD000259.pub2
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NR 26
TC 29
Z9 30
U1 0
U2 12
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1039-8562
EI 1440-1665
J9 AUSTRALAS PSYCHIATRY
JI Australas. Psychiatry
PD OCT
PY 2010
VL 18
IS 5
BP 451
EP 455
DI 10.3109/10398561003731189
PG 5
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 675HD
UT WOS:000283817400013
PM 20863186
DA 2025-06-11
ER

PT J
AU Karupaiah, T
   Chuah, KA
   Chinna, K
   Matsuoka, R
   Masuda, Y
   Sundram, K
   Sugano, M
AF Karupaiah, Tilakavati
   Chuah, Khun-Aik
   Chinna, Karuthan
   Matsuoka, Ryosuke
   Masuda, Yasunobu
   Sundram, Kalyana
   Sugano, Michihiro
TI Comparing effects of soybean oil- and palm olein-based mayonnaise
   consumption on the plasma lipid and lipoprotein profiles in human
   subjects: a double-blind randomized controlled trial with cross-over
   design
SO LIPIDS IN HEALTH AND DISEASE
LA English
DT Article
DE Mayonnaise; Fatty acids; Cardiometabolic risk; Lipids; Lipoprotein
   particles
ID CORONARY-HEART-DISEASE; FATTY-ACIDS; ENZYMATIC DETERMINATION;
   CARDIOVASCULAR-DISEASE; DIETARY FATS; CHOLESTEROL; SERUM; RISK; MEN;
   INFLAMMATION
AB Background: Mayonnaise is used widely in contemporary human diet with widespread use as a salad dressing or spread on breads. Vegetable oils used in its formulation may be a rich source of omega-6 PUFAs and the higher-PUFA content of mayonnaise may be beneficial in mediating a hypocholesterolemic effect. This study, therefore, evaluated the functionality of mayonnaise on cardiometabolic risk within a regular human consumption scenario.
   Methods: Subjects underwent a randomized double-blind crossover trial, consuming diets supplemented with 20 g/day of either soybean oil-based mayonnaise (SB-mayo) or palm olein-based mayonnaise (PO-mayo) for 4 weeks each with a 2-week wash-out period. The magnitude of changes for metabolic outcomes between dietary treatments was compared with PO-mayo serving as the control. The data was analyzed by ANCOVA using the GLM model. Analysis was adjusted for weight changes.
   Results: Treatments resulted in significant reductions in TC (diff = -0.25 mmol/L; P = 0.001), LDL-C (diff = -0. 17 mmol/L; P = 0.016) and HDL-C (diff = -0.12 mmol/L; P < 0.001) in SB-mayo compared to PO-mayo without affecting LDL-C: HDL-C ratio (P > 0.05). Lipoprotein particle change was significant with large LDL particles increasing after PO-mayo (diff = +63.2 nmol/L; P = 0.007) compared to SB-mayo but small LDL particles remained unaffected. Plasma glucose, apolipoproteins and oxidative stress markers remained unchanged.
   Conclusions: Daily use with 20 g of linoleic acid-rich SB-mayo elicited reductions in TC and LDL-C concentrations without significantly changing LDL-C: HDL-C ratio or small LDL particle distributions compared to the PO-mayo diet.
C1 [Karupaiah, Tilakavati] Natl Univ Malaysia, Sch Healthcare Sci, Dietet Program, Fac Hlth Sci, Kuala Lumpur, Malaysia.
   [Chuah, Khun-Aik] Natl Univ Malaysia, Sch Healthcare Sci, Nutr Program, Fac Hlth Sci, Kuala Lumpur, Malaysia.
   [Chinna, Karuthan] Univ Malaya, Dept Social & Prevent Med, Julius Ctr, Fac Med, Kuala Lumpur, Malaysia.
   [Matsuoka, Ryosuke; Masuda, Yasunobu] Kewpie Corp, R&D Div, 2-5-7 Sengawa Cho, Chofu, Tokyo, Japan.
   [Sundram, Kalyana] Malaysian Palm Oil Council, Kelana Jaya, Selangor, Malaysia.
   [Sugano, Michihiro] Kyushu Univ, Kyushu, Japan.
   [Sugano, Michihiro] Prefectual Univ Kumamoto, Kyushu, Japan.
C3 Universiti Kebangsaan Malaysia; Universiti Kebangsaan Malaysia;
   Universiti Malaya; Kyushu University
RP Karupaiah, T (corresponding author), Natl Univ Malaysia, Sch Healthcare Sci, Dietet Program, Fac Hlth Sci, Kuala Lumpur, Malaysia.
EM tilly_karu@yahoo.co.uk
RI Matsuoka, Ryosuke/LOS-1392-2024; chinna, karuthan/E-4495-2014;
   Karupaiah, Tilakavati/C-9868-2013
OI Matsuoka, Ryosuke/0000-0002-4511-6272; KARUPAIAH,
   TILAKAVATI/0000-0001-5808-8074
FU Kewpie Corporation, Japan [NN-188-2010]
FX This study was supported by a grant (NN-188-2010) received from Kewpie
   Corporation, Japan.
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NR 51
TC 27
Z9 29
U1 0
U2 34
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1476-511X
J9 LIPIDS HEALTH DIS
JI Lipids Health Dis.
PD AUG 17
PY 2016
VL 15
AR 131
DI 10.1186/s12944-016-0301-9
PG 11
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA DT7RS
UT WOS:000381684900002
PM 27535127
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Prasad, M
   Goswami, S
   Kurkure, PA
AF Prasad, Maya
   Goswami, Savita
   Kurkure, Purna A.
TI The Care of Childhood Cancer Survivors in India: Challenges and
   Solutions
SO INDIAN JOURNAL OF MEDICAL AND PAEDIATRIC ONCOLOGY
LA English
DT Article
DE childhood cancer survivors; low- and middle-income countries;
   survivorship care
ID OUTCOMES; CHILDREN; BURDEN; RISK
AB Purpose We describe the challenges faced and lessons learnt over three decades of a childhood cancer survivorship program in India.Methods We provide a descriptive analysis of the challenges and barriers faced in running this program, our strategies in management, and detail the stages of development of holistic support system.Results The profile of late effects in our cohort of survivors is notable for the high prevalence of psychosocial issues and metabolic syndrome. Major difficulties faced were transitioning of patients to survivorship care and attrition to follow-up, which were overcome to an extent by ensuring constant communication/rapport-building, updated databases, and peer support groups. Collaborations with nonprofit organizations and other donors have enabled financial, psychosocial, educational, and vocational rehabilitation.Conclusions It is feasible to establish and sustain a survivorship program in a large-volume center in low- and medium-income country. Understanding the unique spectrum of late effects and establishing a holistic support system go a long way in ensuring the long-term physical and mental health and psychosocial concerns of childhood cancer survivors. Decentralization, development of a strong national networks, capacity building, and incorporation of sustainable technology should be priorities in survivorship care.
C1 [Prasad, Maya] Tata Mem Hosp, Div Paediat Oncol, Mumbai, Maharashtra, India.
   [Prasad, Maya; Goswami, Savita] Homi Bhabha Natl Inst HBNI, Mumbai, Maharashtra, India.
   [Goswami, Savita] Tata Mem Hosp, Dept Psychooncol, Mumbai, Maharashtra, India.
   [Kurkure, Purna A.] Narayana Hlth, SRCC Childrens Hosp, Dept Pediat Oncol & Bone Marrow Transplantat, Mumbai, Maharashtra, India.
   [Prasad, Maya] Tata Mem Hosp, Div Paediat Oncol, Mumbai 400012, Maharashtra, India.
C3 Tata Memorial Centre (TMC); Tata Memorial Hospital; Homi Bhabha National
   Institute; Tata Memorial Centre (TMC); Tata Memorial Hospital; Tata
   Memorial Centre (TMC); Tata Memorial Hospital
RP Prasad, M (corresponding author), Tata Mem Hosp, Div Paediat Oncol, Mumbai 400012, Maharashtra, India.
EM maya.prasad@gmail.com
CR Agarwal A, 2022, SUPPORT CARE CANCER, V30, P5075, DOI 10.1007/s00520-022-06910-0
   [Anonymous], Children's Oncology Group Long-Term Follow-Up Guidelines for Survivors of Childhood, Adolescent, and Young Adult Cancers: Health Links- Diet and Physical Activity
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   worldbank, World Bank national accounts data, and OECD National Accounts data files. GDP (current US$)-Nigeria
NR 37
TC 2
Z9 2
U1 0
U2 3
PU THIEME MEDICAL PUBL INC
PI NEW YORK
PA 333 SEVENTH AVE, NEW YORK, NY 10001 USA
SN 0971-5851
EI 0975-2129
J9 INDIAN J MED PAEDIAT
JI Indian J. Med. Paediatr. Oncol.
PD APR
PY 2024
VL 45
IS 02
BP 167
EP 172
DI 10.1055/s-0043-1761262
EA APR 2023
PG 6
WC Oncology
WE Emerging Sources Citation Index (ESCI)
SC Oncology
GA OZ0M1
UT WOS:000974128200008
OA gold
DA 2025-06-11
ER

PT J
AU Mitchell, AJ
   Lawrence, D
AF Mitchell, Alex J.
   Lawrence, David
TI Revascularisation and mortality rates following acute coronary syndromes
   in people with severe mental illness: comparative meta-analysis
SO BRITISH JOURNAL OF PSYCHIATRY
LA English
DT Review
ID INVASIVE CARDIAC PROCEDURES; ACUTE MYOCARDIAL-INFARCTION; CATIE
   SCHIZOPHRENIA TRIAL; INDUCED WEIGHT-GAIN; HEALTH-CARE-SYSTEM;
   QUALITY-OF-CARE; HEART-DISEASE; METABOLIC SYNDROME; EXCESS MORTALITY;
   RELATIVE RISK
AB Background
   High levels of comorbid physical illness and excess mortality rates have been previously documented in people with severe mental illness, but outcomes following myocardial infarction and other acute coronary syndromes are less clear.
   Aims
   To examine inequalities in the provision of invasive coronary procedures (revascularisation, angiography, angioplasty and bypass grafting) and subsequent mortality in people with mental illness and in those with schizophrenia, compared with those without mental ill health.
   Method
   Systematic search and random effects meta-analysis were used according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Studies of mental health and cardiovascular procedures following cardiac events were eligible but we required a minimum of three independent studies to warrant pooling by procedure type. We searched Medline/PubMed and EMBASE abstract databases and Science Direct, Ingenta Select, Springer Link and Online Wiley Library full text databases.
   Results
   We identified 22 analyses of possible inequalities in coronary procedures in those with defined mental disorder, of which 10 also reported results in schizophrenia or related psychosis. All studies following acute coronary syndrome originated in the USA. The total sample size was 825754 individuals. Those with mental disorders received 0.86 (relative risk, RR: 95% CI 0.80-0.92, P<0.0001) of comparable procedures with significantly lower receipt of coronary artery bypass graft (CABG; RR=0.85, 95% CI 0.72-1.00), cardiac catheterisation (RR = 0.85, 95% CI 0.76-0.95) and percutaneous transluminal coronary angioplasty or percutaneous coronary intervention (PTCA/PCI; RR=0.87, 95% CI 0.72-1.05). People with a diagnosis of schizophrenia received only 0.53 (95% CI 0.44-0.64, P<0.0001) of the usual procedure rate with significantly lower receipt of CABG (RR=0.69, 95% CI 0.55-0.85) and PTCA/PCI (RR=0.50, 95% CI 0.34-0.75). We identified 6 related studies examining mortality following cardiac events: for those with mental illness there was a 1.11 relative risk of mortality up to 1 year (95% CI 1.00-1.24, P=0.05) but there was insufficient evidence to examine mortality rates in schizophrenia alone.
   Conclusions
   Following cardiac events, individuals with mental illness experience a 14% lower rate of invasive coronary interventions (47% in the case of schizophrenia) and they have an 11% increased mortality rate. Further work is required to explore whether these factors are causally linked and whether improvements in medical care might improve survival in those with mental ill health.
C1 [Mitchell, Alex J.] Leicestershire Partnership Trust, Dept Liaison Psychiat, Leicester, Leics, England.
   [Mitchell, Alex J.] Leicester Royal Infirm, Dept Canc Studies & Mol Med, Leicester, Leics, England.
   [Lawrence, David] Univ Western Australia, Telethon Inst Child Hlth Res, Ctr Child Hlth Resaerch, Perth, WA 6009, Australia.
C3 University of Leicester; University of Western Australia; The Kids
   Research Institute Australia
RP Mitchell, AJ (corresponding author), Leicester Gen Hosp, Dept Liaison Psychiat, Gwendolen Rd, Leicester LE5 4PW, Leics, England.
EM Alex.mitchell@leicspart.nhs.uk
RI Mitchell, Alex/A-3090-2009; Mitchell, Alex/P-5671-2015; Lawrence,
   David/C-8292-2009
OI Mitchell, Alex/0000-0001-6014-598X; Lawrence, David/0000-0003-4700-1425
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NR 101
TC 87
Z9 90
U1 0
U2 18
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1250
EI 1472-1465
J9 BRIT J PSYCHIAT
JI Br. J. Psychiatry
PD JUN
PY 2011
VL 198
IS 6
BP 434
EP 441
DI 10.1192/bjp.bp.109.076950
PG 8
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 778AR
UT WOS:000291669900006
PM 21628705
OA Bronze
DA 2025-06-11
ER

PT J
AU Khalfallah, M
   Habib, M
   Kishk, AM
   Saeed, B
   Hemdan, S
   Eissa, A
   Aboomar, AA
   Hagag, RY
   Elnagar, B
AF Khalfallah, Mohamed
   Habib, Marwa
   Kishk, Ahmed mustafa
   Saeed, Baraka
   Hemdan, Shreen
   Eissa, Ahmad
   Aboomar, Ahmed a.
   Hagag, Rasha youssef
   Elnagar, Basma
TI Atherosclerotic Cardiovascular Diseases in Middle Delta of Egypt: A
   Systematic Analysis of Risk Factors Associated with the Rising Burden of
   the Disease
SO GLOBAL HEART
LA English
DT Article
DE Atherosclerotic cardiovascular diseases; risk factors; Egypt
ID CORONARY-HEART-DISEASE; PREVENTION
AB Background: The popularity of behavioural and metabolic risk factors associated with atherosclerotic cardiovascular diseases (ACVDs) has increased because of social progress, rapid economic development, population aging, and changes in social ideology. We aimed to perform a systematic analysis of risk factors associated with the rising rate of ACVDs in Egypt. Methods: This study was carried out on 1,700 participants. The patients were classified into two groups: group 1 included patients with ACVDs, and group 2 (control group) included healthy individuals. All data recorded included patients' anthropometric measurements, and laboratory and clinical examinations were collected. Results: The rising burden of ACVDs in Egypt was caused by a variety of risk factors, including diabetes mellitus, smoking, hypertension, dyslipidemia, obesity, and a lack of physical activity. The dominant risk factors recognized through multivariate regression analysis were the existence of metabolic syndrome (OR = 1.463; 95% CI, 1.056-2.026; P = 0.022), increased psychosocial stress among the patients (OR = 1.404; 95% CI, 1.008-1.953; P = 0.044), excessive consumption of high-fat, processed, and fast food (OR = 1.964; 95% CI, 1.489-2.590; P = 0.001), and decreased the income (OR = 1.865; 95% CI, 1.454-2.391; P = 0.001). Conclusions: Patients who suffer from uncontrolled diabetes, dyslipidemia, and metabolic syndrome are the most liable to have ACVDs. Psychosocial stress and the excessive intake of processed, high-fat, and fast food are augmenting leading risk features, especially in low-income populations.
C1 [Khalfallah, Mohamed; Habib, Marwa; Elnagar, Basma] Tanta Univ, Fac Med, Cardiovasc Med Dept, Tanta, Egypt.
   [Kishk, Ahmed mustafa] Tanta Univ, Fac Med, Neurol Med Dept, Tanta, Egypt.
   [Saeed, Baraka; Hemdan, Shreen] Family Med & Community Hlth Dept, Abu Dhabi, U Arab Emirates.
   [Eissa, Ahmad; Aboomar, Ahmed a.; Hagag, Rasha youssef] Tanta Univ, Fac Med, Internal Med Dept, Tanta, Egypt.
C3 Egyptian Knowledge Bank (EKB); Tanta University; Egyptian Knowledge Bank
   (EKB); Tanta University; Egyptian Knowledge Bank (EKB); Tanta University
RP Khalfallah, M (corresponding author), Tanta Univ, Fac Med, Cardiovasc Med Dept, Tanta, Egypt.
EM khalfallah@yahoo.com
RI habib, Marwa/KRR-2042-2024; Hagag, Rasha/JZT-5241-2024; elnagar,
   basma/JKJ-4690-2023; khalfallah, mohamed/AAN-3560-2020; Kishk, Ahmed
   Mustafa/LKO-0848-2024
OI Khalfallah, Mohamed/0000-0002-6105-9300
CR Abd El-Gawad HN, 2022, JRAM, V3, P119, DOI [10.21608/jram.2021.104011.1146, DOI 10.21608/JRAM.2021.104011.1146]
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NR 40
TC 1
Z9 1
U1 0
U2 0
PU UBIQUITY PRESS LTD
PI LONDON
PA Unit 3N, 6 Osborn Street, LONDON, E1 6TD, ENGLAND
SN 2211-8160
EI 2211-8179
J9 GLOB HEART
JI Glob. Heart
PY 2025
VL 20
IS 1
AR 11
DI 10.5334/gh.1395
PG 11
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA X0A1F
UT WOS:001422075700005
PM 39925839
OA gold
DA 2025-06-11
ER

PT J
AU Macaluso, M
   Bianchi, A
   Sanmartin, C
   Taglieri, I
   Venturi, F
   Testai, L
   Flori, L
   Calderone, V
   De Leo, M
   Braca, A
   Ciccone, V
   Donnini, S
   Guidi, L
   Zinnai, A
AF Macaluso, Monica
   Bianchi, Alessandro
   Sanmartin, Chiara
   Taglieri, Isabella
   Venturi, Francesca
   Testai, Lara
   Flori, Lorenzo
   Calderone, Vincenzo
   De Leo, Marinella
   Braca, Alessandra
   Ciccone, Valerio
   Donnini, Sandra
   Guidi, Luca
   Zinnai, Angela
TI By-Products from Winemaking and Olive Mill Value Chains for the
   Enrichment of Refined Olive Oil: Technological Challenges and
   Nutraceutical Features
SO FOODS
LA English
DT Article
DE phenol-enriched olive oil; grape marc; olive pomace; olive leaves;
   phenols; in vitro model; in vivo model; cardiovascular diseases; cancer
   diseases; metabolic syndrome
ID OWN PHENOLIC-COMPOUNDS; WASTE-WATER; VIRGIN; ANTIOXIDANTS;
   HYDROXYTYROSOL; STABILIZATION; INFLAMMATION; POLYPHENOLS; EXTRACTION;
   STABILITY
AB A growing body of literature is available about the valorization of food by-products to produce functional foods that combine the basic nutritional impact with the improvement of the health status of consumers. In this context, this study had two main objectives: (i) An innovative multistep extraction process for the production of a refined olive oil enriched with phenolic compounds (PE-ROO) extracted from olive pomace, olive leaves, or grape marc was presented and discussed. (ii) The most promising PE-ROOs were selected and utilized in in vitro and in vivo trials in order to determine their effectiveness in the management of high fat diet-induced-metabolic syndrome and oxidative stress in rats. The best results were obtained when olive leaves were used as source of phenols, regardless of the chemical composition of the solvent utilized for the extraction. Furthermore, while ethanol/hexane mixture was confirmed as a good solvent for the extraction of phenols compounds soluble in oil, the mix ROO/ethanol also showed a good extracting power from olive leaves. Besides, the ROO enriched with phenols extracted from olive leaves revealed an interesting beneficial effect to counteract high fat diet-induced-metabolic disorder and oxidative stress in rats, closely followed by ROO enriched by utilizing grape marc.
C1 [Macaluso, Monica; Bianchi, Alessandro; Sanmartin, Chiara; Taglieri, Isabella; Venturi, Francesca; Zinnai, Angela] Univ Pisa, Dept Agr Food & Environm DAFE, Via Borghetto 80, I-56124 Pisa, Italy.
   [Sanmartin, Chiara; Venturi, Francesca; Testai, Lara; Calderone, Vincenzo; De Leo, Marinella; Braca, Alessandra; Zinnai, Angela] Univ Pisa, Interdept Res Ctr Nutraceut & Food Hlth, Via Borghetto 80, I-56124 Pisa, Italy.
   [Venturi, Francesca; De Leo, Marinella; Braca, Alessandra; Zinnai, Angela] Pisa Univ, Ctr Instrumentat Sharing, CISUP, Lungarno Pacinotti 43, I-56126 Pisa, Italy.
   [Testai, Lara; Calderone, Vincenzo; De Leo, Marinella; Braca, Alessandra; Ciccone, Valerio] Univ Pisa, Dept Pharm, Via Bonanno Pisano 6, I-56126 Pisa, Italy.
   [Flori, Lorenzo; Donnini, Sandra] Univ Siena, Dept Life Sci, Via Aldo Moro 2, I-53100 Siena, Italy.
   [Ciccone, Valerio; Donnini, Sandra] Toscana Life Sci, Str Petriccio & Belriguardo 35, I-53100 Siena, Italy.
   [Guidi, Luca] SALOV SpA, Via Montramito 1600, I-55054 Massarosa, Italy.
C3 University of Pisa; University of Pisa; University of Pisa; University
   of Pisa; University of Siena
RP Sanmartin, C; Taglieri, I (corresponding author), Univ Pisa, Dept Agr Food & Environm DAFE, Via Borghetto 80, I-56124 Pisa, Italy.; Sanmartin, C (corresponding author), Univ Pisa, Interdept Res Ctr Nutraceut & Food Hlth, Via Borghetto 80, I-56124 Pisa, Italy.
EM monica.macaluso@phd.unipi.it; alessandra.braca@unipi.it;
   chiara.sanmartin@unipi.it; Isabella.taglieri@for.unipi.it;
   francesca.venturi@unipi.it; lara.testai@unipi.it;
   lorenzo.flori@phd.unipi.it; vincenzo.calderone@unipi.it;
   marinella.deleo@unipi.it; alessandra.braca@unipi.it;
   vincenzo.calderone@unipi.it; sandra.donnini@unisi.it;
   luca.guidi@salov.com; angela.zinnai@unipi.it
RI Ciccone, Valerio/AAT-1508-2021; guidi, lucia/ABZ-9443-2022; Bianchi,
   Alessandro/AHC-3063-2022; Donnini, Sandra/K-9252-2019; Taglieri,
   Isabella/AAA-4892-2019; Venturi, Francesca/O-8348-2016; SANMARTIN,
   CHIARA/F-7524-2017; CALDERONE, VINCENZO/L-9288-2015
OI Venturi, Francesca/0000-0002-7844-3253; testai,
   lara/0000-0003-2431-6248; SANMARTIN, CHIARA/0000-0002-7559-1955; Flori,
   Lorenzo/0000-0001-7899-0954; De Leo, Marinella/0000-0002-5544-8457;
   Ciccone, Valerio/0000-0002-5374-9694; Monica,
   Macaluso/0000-0001-7075-4252; Donnini, Sandra/0000-0001-6617-1644;
   BRACA, ALESSANDRA/0000-0002-9838-0448; Taglieri,
   Isabella/0000-0001-6000-9371; Bianchi, Alessandro/0000-0001-6482-527X;
   CALDERONE, VINCENZO/0000-0002-1441-5421
FU Regione Toscana: VALE Project (Grant 1 "Progetti di ricerca e sviluppo",
   FESR 2014-2020) [CUP D56G18000160009]
FX This research was funded by Regione Toscana: VALE Project (Grant 1
   "Progetti di ricerca e sviluppo", FESR 2014-2020, cod. CUP
   D56G18000160009).
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NR 53
TC 14
Z9 14
U1 0
U2 12
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2304-8158
J9 FOODS
JI Foods
PD OCT
PY 2020
VL 9
IS 10
AR 1390
DI 10.3390/foods9101390
PG 21
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA OL5KL
UT WOS:000585378600001
PM 33019655
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Vahedian, Z
   Fakhraie, G
   Bovet, J
   Mozaffarieh, M
AF Vahedian, Zakieh
   Fakhraie, Ghasem
   Bovet, Jerome
   Mozaffarieh, Maneli
TI Nutritional recommendations for individuals with Flammer syndrome
SO EPMA JOURNAL
LA English
DT Review
DE Preventive; Personalized; Flammer syndrome; Oxidative stress;
   Antioxidative nutrition
ID GINKGO-BILOBA-EXTRACT; ZINC-CHELATING SUBSTANCE; RETINAL
   VENOUS-PRESSURE; RED WINE POLYPHENOLS; ANTIOXIDANT CAPACITY;
   BORAGO-OFFICINALIS; DARK CHOCOLATE; BLOOD-PRESSURE; VISUAL-FIELD;
   CIRCULATING LEUKOCYTES
AB The Flammer syndrome (FS) describes the phenotype of people with a predisposition for an altered reaction of the blood vessels to stimuli like coldness or emotional stress. The question whether such people should be treated is often discussed. On the one hand, most of these subjects are healthy; on the other hand, FS seems to predispose to certain eye diseases such as normal tension glaucoma or retinitis pigmentosa or systemic diseases such as multiple sclerosis or tinnitus. A compromise between doing nothing and a drug treatment is the adaption of nutrition. But what do we mean by healthy food consumption for subjects with FS? The adaption of nutrition depends on the health condition. Whereas patients with e.g. a metabolic syndrome should reduce their calorie intake, this can be counterproductive for subjects with FS, as most subjects with FS have already a low body mass index (BMI) and the lower the BMI the stronger the FS symptoms. Accordingly, while fasting is healthy e.g. for subjects with metabolic syndrome, fasting can even dangerously aggravate the vascular dysregulation, as it has been nicely demonstrated by the loss of retinal vascular regulation during fasting. To give another example, while reducing salt intake is recommended for subjects with systemic hypertensions, such a salt restriction can aggravate systemic hypotension and thereby indirectly also the vascular regulation in subjects with FS. This clearly demonstrates that such a preventive adaption of nutrition needs to be personalized.
C1 [Vahedian, Zakieh; Fakhraie, Ghasem] Univ Tehran Med Sci, Farabi Eye Hosp, Glaucoma Serv, Tehran, Iran.
   [Bovet, Jerome; Mozaffarieh, Maneli] Augen Glattzentrum, Zurich, Switzerland.
   [Mozaffarieh, Maneli] Univ Basel, Dept Ophthalmol, Mittlere Str 91, CH-4031 Basel, Switzerland.
C3 Tehran University of Medical Sciences; Farabi Eye Hospital; University
   of Basel
RP Mozaffarieh, M (corresponding author), Augen Glattzentrum, Zurich, Switzerland.; Mozaffarieh, M (corresponding author), Univ Basel, Dept Ophthalmol, Mittlere Str 91, CH-4031 Basel, Switzerland.
EM vahedian.z@gmail.com; gfakhraie@gmail.com; jbovet@vision.tv;
   maneli.mozaffarieh@gmail.com
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NR 114
TC 3
Z9 3
U1 0
U2 17
PU SPRINGER INTERNATIONAL PUBLISHING AG
PI CHAM
PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND
SN 1878-5077
EI 1878-5085
J9 EPMA J
JI EPMA J.
PD JUN
PY 2017
VL 8
IS 2
BP 187
EP 195
DI 10.1007/s13167-017-0093-7
PG 9
WC Medicine, General & Internal; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Research & Experimental Medicine
GA FB0KI
UT WOS:000405833600010
PM 28824740
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Hayden, MR
   Banks, WA
   Shah, GN
   Gu, Z
   Sowers, JR
AF Hayden, M. R.
   Banks, W. A.
   Shah, G. N.
   Gu, Z.
   Sowers, J. R.
TI Cardiorenal Metabolic Syndrome and Diabetic Cognopathy
SO CARDIORENAL MEDICINE
LA English
DT Article
DE Diabetic cognopathy; Alzheimer's disease; Type 2 diabetes mellitus;
   Ultrastructure; Remodeling; Neurovascular unit; Blood-brain barrier
ID BLOOD-BRAIN-BARRIER; RENIN-ANGIOTENSIN SYSTEM; CALCIFIC UREMIC
   ARTERIOLOPATHY; CHRONIC KIDNEY-DISEASE; ALZHEIMERS-DISEASE; VASCULAR
   DEMENTIA; COGNITIVE IMPAIRMENT; OXIDATIVE STRESS; PERICYTES; MELLITUS
AB The prevalence of the cardiorenal metabolic syndrome (CRS) is increasing in parallel with obesity, type 2 diabetes mellitus, Alzheimer's disease, and other forms of dementia. Along with metabolic, inflammatory, and immunological abnormalities, there is maladaptive structural remodeling of the heart, kidney, and brain. The term 'diabetic cognopathy' (DC) may be used when discussing functional and structural changes in the brain of the diabetic patient. DC likely represents an advanced form of these changes in the brain that evolve with increasing duration of the CRS and subsequent clinical diabetes. We posit that DC develops due to a convergence of aging, genetic and lifestyle abnormalities (overnutrition and lack of exercise), which result in multiple injurious metabolic and immunologic toxicities such as dysfunctional immune responses, oxidative stress, inflammation, insulin resistance, and dysglycemia (systemically and in the brain). These converging abnormalities may lead to endothelial blood-brain barrier tight junction/adherens junction (TJ/AJ) complex remodeling and microglia activation, which may result in neurodegeneration, impaired cognition, and dementia. Herein, we describe the brain ultrastructural changes evolving from a normal state to maladaptive remodeling in rodent models of CRS including microglia activation/polarization and attenuation and/or loss of the TJ/AJ complexes, pericytes and astrocytes of the neurovascular unit. Further, we discuss the potential relationship between these structural changes and the development of DC, potential therapeutic strategies, and future directions. (C) 2013 S. Karger AG, Basel
C1 [Hayden, M. R.; Sowers, J. R.] Univ Missouri, Dept Internal Med, Div Endocrinol Diabet & Metab, Columbia, MO 65212 USA.
   [Hayden, M. R.; Gu, Z.; Sowers, J. R.] Univ Missouri, Diabet & Cardiovasc Res Lab, Columbia, MO 65212 USA.
   [Sowers, J. R.] Univ Missouri, Dept Med Pharmacol & Physiol, Columbia, MO 65212 USA.
   [Sowers, J. R.] Harry S Truman Mem Vet Hosp, Columbia, MO 65201 USA.
   [Banks, W. A.] Univ Washington, Dept Med, Div Geriatr Med, Vet Affairs Puget Sound Hlth Care Syst,Geriat Res, Seattle, WA USA.
   [Shah, G. N.] St Louis Univ, Dept Internal Med, Div Endocrinol, St Louis, MO 63103 USA.
C3 University of Missouri System; University of Missouri Columbia;
   University of Missouri System; University of Missouri Columbia;
   University of Missouri System; University of Missouri Columbia; US
   Department of Veterans Affairs; Veterans Health Administration (VHA);
   Harry S. Truman Memorial Veterans' Hospital; US Department of Veterans
   Affairs; Veterans Health Administration (VHA); Vet Affairs Puget Sound
   Health Care System; University of Washington; University of Washington
   Seattle; Saint Louis University
RP Hayden, MR (corresponding author), Univ Missouri, D109 Diabet Ctr HSC,1 Hosp Dr, Columbia, MO 65212 USA.
EM mrh29@usmo.com
RI Banks, William/K-1330-2017; Hayden, Michael/D-8581-2011
FU NIH [R01 HL73101-01A1, R01 HL107910-01]; Veterans Affairs Merit System
   [0018]
FX The authors would like to acknowledge Tommi White, PhD, of the
   University of Missouri Electron Microscopic Core Facility, Columbia,
   Mo., USA, for preparing and staining the transmission electron
   microscopic images for viewing. We wish to acknowledge Brenda Hunter for
   her editorial assistance. The work presented is supported by the NIH
   (R01 HL73101-01A1 and R01 HL107910-01), Veterans Affairs Merit System
   0018 (J.R. Sowers).
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NR 65
TC 16
Z9 16
U1 0
U2 9
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1664-3828
EI 1664-5502
J9 CARDIORENAL MED
JI CardioRenal Med.
PY 2013
VL 3
IS 4
BP 265
EP 282
DI 10.1159/000357113
PG 18
WC Cardiac & Cardiovascular Systems; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Urology & Nephrology
GA 278UL
UT WOS:000328915300007
PM 24474955
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Johnson, RJ
   Perez-Pozo, SE
   Lillo, JL
   Grases, F
   Schold, JD
   Kuwabara, M
   Sato, Y
   Hernando, AA
   Garcia, G
   Jensen, T
   Rivard, C
   Sanchez-Lozada, LG
   Roncal, C
   Lanaspa, MA
AF Johnson, Richard J.
   Perez-Pozo, Santos E.
   Lillo, Julian Lopez
   Grases, Felix
   Schold, Jesse D.
   Kuwabara, Masanari
   Sato, Yuka
   Hernando, Ana Andres
   Garcia, Gabriela
   Jensen, Thomas
   Rivard, Christopher
   Sanchez-Lozada, Laura G.
   Roncal, Carlos
   Lanaspa, Miguel A.
TI Fructose increases risk for kidney stones: potential role in metabolic
   syndrome and heat stress
SO BMC NEPHROLOGY
LA English
DT Article
DE Fructose; Sugar; Sucrose; Kidney stone; Magnesium; Uric acid; Citrate;
   Oxalate
ID URINARY URIC-ACID; UNITED-STATES; INDUCED HYPERURICEMIA; SUGARCANE
   HARVESTERS; ORAL FRUCTOSE; RENAL INJURY; NEPHROLITHIASIS; OXALATE;
   DISEASE; PREVALENCE
AB BackgroundFructose intake, mainly as table sugar or high fructose corn syrup, has increased in recent decades and is associated with increased risk for kidney stones. We hypothesized that fructose intake alters serum and urinary components involved in stone formation.MethodsWe analyzed a previously published randomized controlled study that included 33 healthy male adults (40-65years of age) who ingested 200g of fructose (supplied in a 2-L volume of 10% fructose in water) daily for 2weeks. Participants were evaluated at the Unit of Nephrology of the Mateo Orfila Hospital in Menorca. Changes in serum levels of magnesium, calcium, uric acid, phosphorus, vitamin D, and intact PTH levels were evaluated. Urine magnesium, calcium, uric acid, phosphorus, citrate, oxalate, sodium, potassium, as well as urinary pH, were measured.ResultsIngestion of fructose was associated with an increased serum level of uric acid (p<0.001), a decrease in serum ionized calcium (p=0.003) with a mild increase in PTH (p<0.05) and a drop in urinary pH (p=0.02), an increase in urine oxalate (p=0.016) and decrease in urinary magnesium (p=0.003).ConclusionsFructose appears to increase urinary stone formation in part via effects on urate metabolism and urinary pH, and also via effects on oxalate. Fructose may be a contributing factor for the development of kidney stones in subjects with metabolic syndrome and those suffering from heat stress.Trial registrationClinicalTrials.gov NCT00639756 March 20, 2008.
C1 [Johnson, Richard J.; Kuwabara, Masanari; Sato, Yuka; Hernando, Ana Andres; Garcia, Gabriela; Jensen, Thomas; Rivard, Christopher; Roncal, Carlos; Lanaspa, Miguel A.] Univ Colorado, Div Renal Dis & Hypertens, Denver, CO 80202 USA.
   [Johnson, Richard J.] Eastern Colorado Hlth Care Syst, Dept Vet Affairs, Denver, CO 80220 USA.
   [Perez-Pozo, Santos E.] Clin San Felipe, Div Nephrol, Lima, Peru.
   [Lillo, Julian Lopez] Hosp Mateu Orfila, Menorca, Spain.
   [Grases, Felix] Univ Balearic Isl, IUNICS Idisba, Palma De Mallorca, Spain.
   [Schold, Jesse D.] Cleveland Clin Fdn, Dept Quantitat Hlth Sci, 9500 Euclid Ave, Cleveland, OH 44195 USA.
   [Sanchez-Lozada, Laura G.] Inst Nacl Cardiol, Lab Renal Physiopathol, Mexico City, DF, Mexico.
   [Johnson, Richard J.] Univ Colorado, Div Renal Dis, Anschutz Med Campus, Aurora, CO 80045 USA.
C3 University of Colorado System; University of Colorado Denver; Hospital
   Mateu Orfila; Universitat de les Illes Balears; Institut Investigacio
   Sanitaria Illes Balears (IdISBa); Cleveland Clinic Foundation; National
   Institute of Cardiology - Mexico; University of Colorado System;
   University of Colorado Anschutz Medical Campus
RP Johnson, RJ (corresponding author), Univ Colorado, Div Renal Dis & Hypertens, Denver, CO 80202 USA.; Johnson, RJ (corresponding author), Eastern Colorado Hlth Care Syst, Dept Vet Affairs, Denver, CO 80220 USA.
EM richard.johnson@ucdenver.edu
RI Lanaspa, Miguel/AAO-4971-2020; Schold, Jesse/AAC-5844-2019;
   Sanchez-Lozada, Laura/AAS-2104-2021; Kuwabara, Masanari/O-9844-2017
OI Johnson, Richard/0000-0003-3312-8193; Kuwabara,
   Masanari/0000-0002-6601-4347; Sanchez-Lozada,
   Laura-Gabriela/0000-0003-0348-9617; Andres-Hernando,
   Ana/0000-0002-0676-0188
FU Mateu Orfila Fundation; Institute for Research in Health Sciences
   (IUNICS) at the University of the Balearic Islands (Palma de Mallorca,
   Spain)
FX This work was supported by the Mateu Orfila Fundation and the Institute
   for Research in Health Sciences (IUNICS) at the University of the
   Balearic Islands (Palma de Mallorca, Spain).
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NR 72
TC 43
Z9 47
U1 0
U2 13
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1471-2369
J9 BMC NEPHROL
JI BMC Nephrol.
PD NOV 8
PY 2018
VL 19
AR 315
DI 10.1186/s12882-018-1105-0
PG 7
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA GZ9XL
UT WOS:000449856000005
PM 30409184
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Aneni, EC
   Oni, ET
   Osondu, CU
   Martin, SS
   Blaha, MJ
   Veledar, E
   Agatston, AS
   Feldman, T
   Carvalho, JAM
   Conceiçao, RD
   Santos, RD
   Nasir, K
AF Aneni, Ehimen C.
   Oni, Ebenezer T.
   Osondu, Chukwuemeka U.
   Martin, Seth S.
   Blaha, Michael J.
   Veledar, Emir
   Agatston, Arthur S.
   Feldman, Theodore
   Carvalho, Jose A. M.
   Conceicao, Raquel D.
   Santos, Raul D.
   Nasir, Khurram
TI Obesity Modifies the Effect of Fitness on Heart Rate Indices during
   Exercise Stress Testing in Asymptomatic Individuals
SO CARDIOLOGY
LA English
DT Article
DE Fitness; Obesity; Body mass index; Heart rate; Stress test; Metabolic
   equivalents
ID ALL-CAUSE MORTALITY; RATE RECOVERY; CARDIORESPIRATORY FITNESS;
   CARDIOMETABOLIC RISK; PHYSICAL-ACTIVITY; RATE RESPONSE; PREDICTOR;
   HEALTHY; ASSOCIATION; CONSUMPTION
AB Objective: To assess the impact of aerobic fitness on exercise heart rate (HR) indices in an asymptomatic cohort across different body mass index (BMI) categories. Methods: We performed a cross-sectional analysis of 506 working-class Brazilian subjects, free of known clinical cardiovascular disease (e.g. ischemic heart disease and stroke) who underwent an exercise stress test. Results: There was a significant trend towards decreased HR at peak exercise, HR recovery and chronotropic index (CI) measures as BMI increased, but resting HR increased significantly across BMI categories. In multivariate analysis, the change in CI per unit change in metabolic equivalents of task was greater among the obese subjects than the normal-weight (2.7 vs. -0.07; p interaction = 0.029) and overweight (2.7 vs. 0.7; p interaction = 0.044) subjects. A similar pattern was seen with peak HR and HR recovery, although the formal tests of interaction did not achieve statistical significance. Conclusion: Our findings strongly suggest that fitness is associated with a favorable HR profile and is modified by BMI. Intervention programs should place emphasis on fitness and not only on weight loss. (C) 2015 S. Karger AG, Basel
C1 [Aneni, Ehimen C.; Osondu, Chukwuemeka U.; Veledar, Emir; Agatston, Arthur S.; Feldman, Theodore; Nasir, Khurram] Baptist Hlth South Florida, Ctr Healthcare Adv & Outcomes, Miami, FL USA.
   Mt Sinai Med Ctr, Miami Beach, FL 33140 USA.
   [Veledar, Emir; Nasir, Khurram] Florida Int Univ, Robert Stempel Coll Publ Hlth, Miami, FL 33199 USA.
   [Nasir, Khurram] Florida Int Univ, Herbert Wertheim Coll Med, Miami, FL 33199 USA.
   [Oni, Ebenezer T.] Brooklyn Hosp, Brooklyn, NY USA.
   [Martin, Seth S.; Blaha, Michael J.; Nasir, Khurram] Johns Hopkins Ciccarone Ctr Prevent Cardiovasc Di, Baltimore, MD USA.
   [Veledar, Emir] Emory Univ, Sch Med, Dept Med, Atlanta, GA USA.
   [Carvalho, Jose A. M.; Conceicao, Raquel D.; Santos, Raul D.] Univ Sao Paulo, Med Sch Hosp, Hosp Israelita Albert Einstein, Sao Paulo, Brazil.
   [Carvalho, Jose A. M.; Conceicao, Raquel D.; Santos, Raul D.] Univ Sao Paulo, Med Sch Hosp, Heart Inst InCor, Sao Paulo, Brazil.
   [Nasir, Khurram] Baptist Hlth South Florida, Miami Cardiac & Vasc Inst, Miami, FL USA.
C3 Mount Sinai Medical Center; State University System of Florida; Florida
   International University; State University System of Florida; Florida
   International University; Brooklyn Hospital Center; Johns Hopkins
   University; Johns Hopkins Medicine; Emory University; Universidade de
   Sao Paulo; Hospital Israelita Albert Einstein; Universidade de Sao
   Paulo; Baptist Cardiac & Vascular Institute
RP Aneni, EC (corresponding author), 1500 San Remo Ave,Suite 350, Miami, FL 33146 USA.
EM ehimena@baptisthealth.net
RI Veledar, Emir/L-6637-2019; Nasir, Khurram/A-2317-2008; Santos,
   Raul/A-1170-2010; Osondu, Chukwuemeka/JXY-7302-2024
OI Veledar, Emir/0000-0002-3831-5433; Martin, Seth/0000-0002-7021-7622
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NR 32
TC 3
Z9 6
U1 0
U2 16
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0008-6312
EI 1421-9751
J9 CARDIOLOGY
JI Cardiology
PY 2015
VL 132
IS 4
BP 242
EP 248
DI 10.1159/000435907
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA CT7CM
UT WOS:000362970900006
PM 26329389
DA 2025-06-11
ER

PT J
AU Leite-Almeida, L
   Morato, M
   Cosme, D
   Afonso, J
   Areias, JC
   Guerra, A
   Afonso, AC
   Albino-Teixeira, A
   Sousa, T
   Correia-Costa, L
AF Leite-Almeida, Laura
   Morato, Manuela
   Cosme, Dina
   Afonso, Joana
   Areias, Jose C.
   Guerra, Antonio
   Afonso, Alberto Caldas
   Albino-Teixeira, Antonio
   Sousa, Teresa
   Correia-Costa, Liane
TI Impact of physical activity on redox status and nitric oxide
   bioavailability in nonoverweight and overweight/obese prepubertal
   children
SO FREE RADICAL BIOLOGY AND MEDICINE
LA English
DT Article
DE Childhood obesity; Oxidative stress; Nitric oxide; Antioxidant capacity;
   Cardiometabolic risk factors; Physical activity; Exercise
ID OXIDATIVE STRESS; CARDIOVASCULAR RISK; INSULIN-RESISTANCE; OBESE
   CHILDREN; RENAL-FUNCTION; NORMAL-WEIGHT; EXERCISE; ASSOCIATION;
   DYSFUNCTION; FITNESS
AB Nutritional status might contribute to variations induced by physical activity (PA) in redox status biomarkers. We investigated the influence of PA on redox status and nitric oxide (NO) production/metabolism biomarkers in nonoverweight and overweight/obese prepubertal children. We performed a cross-sectional evaluation of 313 children aged 8-9 years (163 nonoverweight, 150 overweight/obese) followed since birth in a cohort study (Generation XXI, Porto, Portugal). Plasma total antioxidant status (P-TAS), plasma and urinary isoprostanes (P-Isop, U-Isop), urinary hydrogen peroxide (U-H2O2), myeloperoxidase (MPO) and plasma and urinary nitrates and nitrites (P-NOx, U-NOx) were assessed, as well as their association with variables of reported PA quantification (categories of PA frequency (>1x/week and <= 1x/week)and continuous PA index (obtained by the sum of points)) in a questionnaire with increasing ranks from sedentary to vigorous activity levels. U-NOx was significantly higher in children who presented higher PA index scores and higher PA frequency. Separately by BMI classes, U-NOx was significantly higher only in nonoverweight children who practiced PA more frequently (p = 0.037). In overweight/obese children, but not in nonoverweight, P-TAS was higher among children with higher PA frequency (p = 0.007). Homeostasis model assessment index (HOMA-IR) was significantly lower in more active overweight/obese children, but no differences were observed in nonoverweight children. In the fully adjusted multivariate linear regression models for P-TAS, in the overweight/obese group, children with higher PA frequency presented higher P-TAS. In the U-NOx models, U-NOx significantly increased with PA index, only in nonoverweight children. Our results provide additional evidence in support of a protective effect of physical activity, in nonoverweight by increasing NO bioavailability and in overweight/obese children by enhancing systemic antioxidant capacity and insulin sensitivity. These results highlight the importance of engaging in regular physical exercise, particularly among overweight/obese children, in which a positive association between oxidant status and cardiometabolic risk markers has been described.
C1 [Leite-Almeida, Laura; Afonso, Alberto Caldas; Correia-Costa, Liane] Univ Porto, Inst Ciencias Biomed Abel Salazar, Porto, Portugal.
   [Morato, Manuela] Univ Porto, Fac Pharm Porto, Dept Drug Sci, Lab Pharmacol, Porto, Portugal.
   [Morato, Manuela] Univ Porto, Fac Pharm Porto, LAQV REQUIMTE, Porto, Portugal.
   [Cosme, Dina; Afonso, Joana; Albino-Teixeira, Antonio; Sousa, Teresa] Univ Porto, Dept Biomed, Unit Pharmacol & Therapeut, Fac Med, Porto, Portugal.
   [Cosme, Dina; Afonso, Joana; Albino-Teixeira, Antonio; Sousa, Teresa] Univ Porto, MedInUP Ctr Drug Discovery & Innovat Med, Porto, Portugal.
   [Areias, Jose C.; Guerra, Antonio] Univ Porto, Dept Gynecol Obstet & Pediat, Fac Med, Porto, Portugal.
   [Areias, Jose C.] Ctr Hosp Univ Sao Joao, Integrated Pediat Hosp, Div Pediat Cardiol, Porto, Portugal.
   [Guerra, Antonio] Ctr Hosp Univ Sao Joao, Integrated Pediat Hosp, Div Pediat Nutr, Porto, Portugal.
   [Afonso, Alberto Caldas; Correia-Costa, Liane] Univ Porto, EPIUnit Inst Saude Publ, Porto, Portugal.
   [Afonso, Alberto Caldas; Correia-Costa, Liane] Ctr Hosp Univ Porto, Ctr Maternoinfantil Norte, Dept Pediat Nephrol, Porto, Portugal.
C3 Universidade do Porto; Universidade do Porto; Universidade do Porto;
   Universidade do Porto; Universidade do Porto; Universidade do Porto;
   Universidade do Porto; Universidade do Porto
RP Correia-Costa, L (corresponding author), Inst Sande Publ Univ Porto ISPUP, Rua Taipas 135, P-4050600 Porto, Portugal.
EM lianecosta@icbas.up.pt
RI Afonso, Carlos/M-7833-2013; , Teresa/HSF-0698-2023; Morato,
   Manuela/D-7563-2013; Correia-Costa, Liane/JPA-4135-2023;
   Albino-Teixeira, Antonio/HPI-0713-2023
OI Morato, Manuela/0000-0002-9509-0613; Correia-Costa,
   Liane/0000-0002-8216-090X; Albino-Teixeira, Antonio/0000-0003-0097-2953;
   Sousa, Teresa/0000-0001-7230-5020; Cosme, Dina/0000-0002-8398-0184;
   Leite-Almeida, Laura/0000-0003-2319-1332
FU FEDER funds from Programa Operacional Factores de Competitividade -
   COMPETE [FCOMP-01-0124-FEDER-028751]; Portuguese Foundation for Science
   and Technology (FCT), Lisbon, Portugal [PTDC/DTP-PIC/0239/2012];
   Calouste Gulbenkian Foundation; FCT [SFRH/SINTD/95898/2013]; FCT;
   POPH/FSE (EC) [SFRH/BPD/112005]; POPH/FSE (EC) [Ciencia 2008]; Fundação
   para a Ciência e a Tecnologia [PTDC/DTP-PIC/0239/2012] Funding Source:
   FCT
FX This project was supported by FEDER funds from Programa Operacional
   Factores de Competitividade - COMPETE [FCOMP-01-0124-FEDER-028751], by
   national funds from the Portuguese Foundation for Science and Technology
   (FCT), Lisbon, Portugal [PTDC/DTP-PIC/0239/2012] and by Calouste
   Gulbenkian Foundation. Liane CorreiaCosta was supported by FCT
   [SFRH/SINTD/95898/2013] and Teresa Sousa was supported by FCT and
   POPH/FSE (EC) [Ciencia 2008 and SFRH/BPD/112005].
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NR 67
TC 9
Z9 9
U1 0
U2 2
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0891-5849
EI 1873-4596
J9 FREE RADICAL BIO MED
JI Free Radic. Biol. Med.
PD FEB 1
PY 2021
VL 163
BP 116
EP 124
DI 10.1016/j.freeradbiomed.2020.12.005
PG 9
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA PY6YT
UT WOS:000612189300003
PM 33309779
OA Green Published
DA 2025-06-11
ER

PT J
AU De Rosa, C
   Sampogna, G
   Luciano, M
   Del Vecchio, V
   Pocai, B
   Borriello, G
   Giallonardo, V
   Savorani, M
   Pinna, F
   Pompili, M
   Fiorillo, A
AF De Rosa, Corrado
   Sampogna, Gaia
   Luciano, Mario
   Del Vecchio, Valeria
   Pocai, Benedetta
   Borriello, Giuseppina
   Giallonardo, Vincenzo
   Savorani, Micaela
   Pinna, Federica
   Pompili, Maurizio
   Fiorillo, Andrea
TI Improving physical health of patients with severe mental disorders: a
   critical review of lifestyle psychosocial interventions
SO EXPERT REVIEW OF NEUROTHERAPEUTICS
LA English
DT Review
DE Severe mental illness; lifestyle behaviours; mortality rate; physical
   health; psychosocial intervention; schizophrenia; bipolar disorder;
   depression
ID RANDOMIZED CONTROLLED-TRIAL; MAJOR DEPRESSIVE DISORDER; BIPOLAR I
   DISORDER; PSYCHOEDUCATIONAL FAMILY INTERVENTION; CARDIOVASCULAR-DISEASE
   RISK; REDUCTION INTERVENTION; 1ST-EPISODE PSYCHOSIS; SEDENTARY BEHAVIOR;
   METABOLIC SYNDROME; SMOKING-CESSATION
AB Introduction: People with severe mental disorders have a mortality rate that is more than two times higher than the general population, with at least a decade of potential years of life lost. People with mental disorders have a significantly higher risk of obesity, hyperglycemia and metabolic syndrome, which are related to modifiable risk factors, such as heavy smoking, poor physical activities, and inappropriate unhealthy diet, which can be improved through lifestyle changes.Areas covered: Lifestyle behaviours are amenable to change through the adoption of specific psychosocial interventions, and several approaches have been promoted. In the present review, the authors aim to: 1) critically analyze studies involving multimodal lifestyle interventions; 2) discuss the way forward to integrate these interventions in clinical routine care.Expert commentary: The psychoeducational approaches developed for the improvement of healthy lifestyle behaviours differ for several aspects: 1) the format (individual vs. group); 2) the setting (outpatient vs. inpatient vs. home-based); 3) the professional characteristics of the staff running the intervention (psychiatrists or nurses or dietitians or psychologists); 4) the active ingredients of the intervention (education only or inclusion of motivational interview or of problem solving); 5) the duration of treatment (ranging from 3months to 2years).
C1 [De Rosa, Corrado; Sampogna, Gaia; Luciano, Mario; Del Vecchio, Valeria; Pocai, Benedetta; Borriello, Giuseppina; Giallonardo, Vincenzo; Savorani, Micaela; Fiorillo, Andrea] Univ Naples SUN, Dept Psychiat, Naples, Italy.
   [Pinna, Federica] Univ Cagliari, Sect Psychiat, Dept Publ Hlth Clin & Mol Med, Cagliari, Italy.
   [Pompili, Maurizio] Sapienza Univ Rome, Suicide Prevent Ctr, Dept Neurosci Mental Hlth & Sensory Organs, Rome, Italy.
C3 Universita della Campania Vanvitelli; University of Cagliari; Sapienza
   University Rome
RP Fiorillo, A (corresponding author), Univ Naples SUN, Dept Psychiat, Naples, Italy.
EM andrea.fiorillo@unina2.it
RI Pompili, Maurizio/AAC-1011-2019; Pinna, Federica/LRU-3388-2024;
   Fiorillo, Andrea/AHH-4551-2022; Sampogna, Gaia/AHH-4608-2022
OI Pinna, Federica/0000-0002-3108-9509; Fiorillo,
   Andrea/0000-0002-6926-0762; Sampogna, Gaia/0000-0002-9547-2793; ,
   Vincenzo/0000-0003-3294-1748; Luciano, Mario/0000-0002-4338-1371
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NR 92
TC 40
Z9 40
U1 0
U2 35
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1473-7175
EI 1744-8360
J9 EXPERT REV NEUROTHER
JI Expert Rev. Neurother.
PY 2017
VL 17
IS 7
BP 667
EP 681
DI 10.1080/14737175.2017.1325321
PG 15
WC Clinical Neurology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Pharmacology & Pharmacy
GA EX7EZ
UT WOS:000403412200005
PM 28468528
DA 2025-06-11
ER

PT J
AU Wickrama, T
   Merten, MJ
   Wickrama, KAS
AF Wickrama, Thulitha
   Merten, Michael J.
   Wickrama, K. A. S.
TI Early community influence on young adult physical health: Race/ethnicity
   and gender differences
SO ADVANCES IN LIFE COURSE RESEARCH
LA English
DT Article
DE Community; Childhood; Young adulthood; Physical health; Race/ethnicity;
   Adolescence
ID ARTERY RISK DEVELOPMENT; METABOLIC SYNDROME; MENTAL-HEALTH; RESIDENTIAL
   SEGREGATION; HEART-DISEASE; LIFE-COURSE; CHILDREN; FAMILY; SUPPORT;
   ASSOCIATION
AB The purpose of this study was to examine the implications of childhood community contexts in the U.S. for physical health problems related to impaired metabolic conditions, and coronary/cardiovascular diseases during young adulthood. Data came from Waves 1 and 4 (1995 and 2008) of the National Longitudinal Study of Adolescent Health (N = 11,845). Multilevel logistic-normal regression was used to examine the relative risk or odds ratios of physical health problems in young adulthood (2008), based on both 1990 census level and 1995 survey data. Childhood community disadvantage and minority concentration increased the risk of young adult obesity, hypertension, diabetes, and high cholesterol. However, the influence of both community disadvantage and minority concentration on young adult physical health outcomes differed by race/ethnicity. Our findings clearly point to the increased risk of physical health problems related to coronary and cardiovascular diseases when a child is raised in an adverse and minority concentrated community. This influence of the community was pervasive and independent of family characteristics. Programs should combat adverse community conditions and enhance resiliencies of youth and families living in such communities. (C) 2012 Elsevier Ltd. All rights reserved.
C1 [Wickrama, Thulitha] Auburn Univ, Dept Human Dev & Family Studies, Auburn, AL 36849 USA.
   [Merten, Michael J.] Oklahoma State Univ, Dept Human Dev & Family Sci, Tulsa, OK 74106 USA.
   [Wickrama, K. A. S.] Univ Georgia, Dept Child & Family Dev, Athens, GA 30602 USA.
C3 Auburn University System; Auburn University; Oklahoma State University
   System; Oklahoma State University - Tulsa; University System of Georgia;
   University of Georgia
RP Wickrama, T (corresponding author), Auburn Univ, Dept Human Dev & Family Studies, 288 Spidle Hall, Auburn, AL 36849 USA.
EM tzw0003@auburn.edu; michael.merten@okstate.edu; wickrama@uga.edu
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NR 67
TC 10
Z9 11
U1 2
U2 16
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1040-2608
J9 ADV LIFE COURSE RES
JI Adv. Life Course Res.
PD MAR
PY 2012
VL 17
IS 1
BP 25
EP 33
DI 10.1016/j.alcr.2012.01.001
PG 9
WC Social Sciences, Interdisciplinary
WE Social Science Citation Index (SSCI)
SC Social Sciences - Other Topics
GA 912AF
UT WOS:000301765100003
DA 2025-06-11
ER

PT J
AU Akbar, Z
   Shi, ZM
AF Akbar, Zoha
   Shi, Zumin
TI Dietary Patterns and Circadian Syndrome among Adults Attending NHANES
   2005-2016
SO NUTRIENTS
LA English
DT Article
DE diet; dietary patterns; circadian rhythms; circadian syndrome; NHANES
ID METABOLIC SYNDROME; SLEEP; PREGNANCY; RHYTHMS; CLOCK; METAANALYSIS;
   DISEASE; HEALTH; RISK
AB The study aimed to assess the associations of dietary patterns and circadian syndrome (CircS). Data from National Health and Nutrition Examination Survey (NHANES) 2005-2016 were analyzed (n = 10,486). Factor analysis was used to construct dietary patterns based on two 24 h food recalls. CircS was defined based on components of the metabolic syndrome, with the addition of short sleep and depression symptoms. Multivariable logistic regression was used to analyze the associations. Two major dietary patterns were identified. The Western dietary pattern had high loadings of refined grains, solid fats, added sugars, and red and cured meats, while the prudent pattern was characterized by a high intake of vegetables, whole grains, oils, nuts, and seeds. The prevalence of CircS was 41.3%. Comparing extreme quartiles of intake, the odds ratios (OR) for having CircS were 1.96 (95%CI 1.53-2.53) and 0.71 (95%CI 0.58-0.86) for the Western pattern and prudent pattern, respectively. The association between the Western dietary pattern and CircS was stronger among men (OR = 2.05; 95%CI 1.48-2.85) and those with low income (OR = 1.94; 95%CI 1.27-2.96) and high education (OR = 3.38; 95%CI 1.90-6.04). The Western dietary pattern was associated with a higher likelihood of having CircS, while the prudent pattern was inversely associated with CircS.
C1 [Akbar, Zoha; Shi, Zumin] Qatar Univ, Coll Hlth Sci, Human Nutr Dept, QU Hlth, POB 2713, Doha, Qatar.
C3 Qatar University
RP Shi, ZM (corresponding author), Qatar Univ, Coll Hlth Sci, Human Nutr Dept, QU Hlth, POB 2713, Doha, Qatar.
EM za1404491@qu.edu.qa; zumin@qu.edu.qa
RI Shi, Zumin/A-1093-2009
OI Shi, Zumin/0000-0002-3099-3299; Akbar, Zoha/0000-0002-7287-0027
FU Qatar University [QUST-1-CHS-2023-810]
FX This research was supported by the Qatar University student grant
   QUST-1-CHS-2023-810.
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NR 58
TC 12
Z9 12
U1 3
U2 28
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD AUG
PY 2023
VL 15
IS 15
AR 3396
DI 10.3390/nu15153396
PG 15
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA O7NE6
UT WOS:001045625700001
PM 37571333
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Boleti, APD
   Cardoso, PHD
   Frihling, BEF
   Silva, PSE
   de Moraes, LFRN
   Migliolo, L
AF Boleti, Ana Paula de A.
   Cardoso, Pedro Henrique de O.
   Frihling, Breno Emanuel F.
   Souza e Silva, Patricia
   de Moraes, Luiz Filipe R. N.
   Migliolo, Ludovico
TI Adipose tissue, systematic inflammation, and neurodegenerative diseases
SO NEURAL REGENERATION RESEARCH
LA English
DT Review
DE adiposity; anti-obesity drugs; hypothalamic inflammation; metabolic
   disease; neurodegenerative disease; neuroinflammation
ID BODY-MASS INDEX; BETA/NF-KAPPA-B; WEIGHT-LOSS; COGNITIVE FUNCTION;
   LIPASE INHIBITOR; METABOLIC SYNDROME; RECEPTOR AGONISTS; GLYCEMIC
   CONTROL; GASTRIC BYPASS; CLINICAL-TRIAL
AB Obesity is associated with several diseases, including mental health. Adipose tissue is distributed around the internal organs, acting in the regulation of metabolism by storing and releasing fatty acids and adipokine in the tissues. Excessive nutritional intake results in hypertrophy and proliferation of adipocytes, leading to local hypoxia in adipose tissue and changes in these adipokine releases. This leads to the recruitment of immune cells to adipose tissue and the release of pro-inflammatory cytokines. The presence of high levels of free fatty acids and inflammatory molecules interfere with intracellular insulin signaling, which can generate a neuroinflammatory process. In this review, we provide an up-to-date discussion of how excessive obesity can lead to possible cognitive dysfunction. We also address the idea that obesity-associated systemic inflammation leads to neuroinflammation in the brain, particularly the hypothalamus and hippocampus, and that this is partially responsible for these negative cognitive outcomes. In addition, we discuss some clinical models and animal studies for obesity and clarify the mechanism of action of anti-obesity drugs in the central nervous system.
C1 [Boleti, Ana Paula de A.; Cardoso, Pedro Henrique de O.; Frihling, Breno Emanuel F.; Souza e Silva, Patricia; de Moraes, Luiz Filipe R. N.; Migliolo, Ludovico] Univ Catolica Dom Bosco, Programa Posgrad Biotecnol, S Inova Biotech, Campo Grande, MS, Brazil.
   [Migliolo, Ludovico] Univ Fed Rio Grande do Norte, Programa Posgrad Bioquim, Programa Posgrad Biol Celular & Mol, Natal, RN, Brazil.
C3 Universidade Catolica Dom Bosco (UCDB); Universidade Federal do Rio
   Grande do Norte
RP Migliolo, L (corresponding author), Univ Catolica Dom Bosco, Programa Posgrad Biotecnol, S Inova Biotech, Campo Grande, MS, Brazil.; Migliolo, L (corresponding author), Univ Fed Rio Grande do Norte, Programa Posgrad Bioquim, Programa Posgrad Biol Celular & Mol, Natal, RN, Brazil.
EM ludovico@ucdb.br
RI Migliolo, Ludovico/AAV-6913-2021; Cardoso, Pedro/B-3546-2019; De
   Oliveira Cardoso, Pedro Henrique/KUF-2487-2024
OI Frihling, Breno Emanuel/0000-0002-3749-9410; MIGLIOLO,
   LUDOVICO/0000-0002-6606-2189; De Oliveira Cardoso, Pedro
   Henrique/0000-0002-2872-3767
FU Brazilian funding agency CNPq; Brazilian funding agency FUNDECT
FX This work was supported by the Brazilian funding agencies CNPq, and
   FUNDECT (to LM).
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NR 169
TC 37
Z9 37
U1 3
U2 69
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, Maharashtra, INDIA
SN 1673-5374
EI 1876-7958
J9 NEURAL REGEN RES
JI Neural Regen. Res.
PD JAN
PY 2023
VL 18
IS 1
BP 38
EP 46
DI 10.4103/1673-5374.343891
PG 9
WC Cell Biology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Neurosciences & Neurology
GA 5H5IK
UT WOS:000867712700005
PM 35799506
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Tamayo, A
   Karter, AJ
   Mujahid, MS
   Warton, EM
   Moffet, HH
   Adler, N
   Schillinger, D
   O'Connell, BH
   Laraia, B
AF Tamayo, Aracely
   Karter, Andrew J.
   Mujahid, Mahasin S.
   Warton, E. Margaret
   Moffet, Howard H.
   Adler, Nancy
   Schillinger, Dean
   O'Connell, Bethany Hendrickson
   Laraia, Barbara
TI Associations of perceived neighborhood safety and crime with
   cardiometabolic risk factors among a population with type 2 diabetes
SO HEALTH & PLACE
LA English
DT Article
DE Neighborhood; Safety; Crime; Diabetes; Obesity
ID POISSON REGRESSION APPROACH; PHYSICAL-ACTIVITY; SOCIAL-ENVIRONMENT;
   HEALTH BEHAVIORS; MANAGED CARE; PERCEPTIONS; OBESITY; RELIABILITY;
   OUTCOMES; PEOPLE
AB Little is known about how neighborhood crime may relate to health in diabetes patients. We examined associations between individuals' perceptions of neighborhood safety or violent crime and stress, physical activity, body mass index (BMI) or hemoglobin A1c (HbA1c) in a sample (n=721) of adults (mean age:63) with diabetes. Self-reported neighborhood safety, violent crime, physical activity, and stress were collected and linked to clinical measures of BMI and HbA1c. Approximately 54% and 15% of patients reported neighborhood safety concerns and violent crimes, respectively. Any neighborhood safety concerns (beta=1.14, 95% C.I. 0.04-2.24) and violent crime (beta=2.04, 95% C.I. 0.34-3.73) were associated with BMI in adjusted analysis. Any violent crime was associated with class II-III obesity (BMI >= 35) (OR=1.34, 95% C.I.:. 1.02, 1.75). There were no significant associations between neighborhood safety concerns or violent crime with stress, physical activity, or HbA1c. Neighborhood safety is associated with BMI and obesity. Further studies, including longitudinal designs, are needed to study how people with diabetes may be influenced by a sense of poor personal safety in their neighborhoods. (C) 2016 Elsevier Ltd. All rights reserved.
C1 [Tamayo, Aracely] Univ Calif Berkeley, Berkeley Sch Publ Hlth, Div Epidemiol, 101 Haviland Hall, Berkeley, CA 94720 USA.
   [Karter, Andrew J.; Warton, E. Margaret; Moffet, Howard H.] Kaiser Permanente, Div Res, Oakland, CA USA.
   [Mujahid, Mahasin S.] Univ Calif Berkeley, Sch Publ Hlth, Div Epidemiol, Berkeley, CA USA.
   [Adler, Nancy] Univ Calif San Francisco, Ctr Hlth & Community, San Francisco, CA 94143 USA.
   [Schillinger, Dean] Univ Calif San Francisco, Div Gen Internal Med, Ctr Vulnerable Populat, San Francisco Gen Hosp, San Francisco, CA 94143 USA.
   [O'Connell, Bethany Hendrickson] Univ Calif Berkeley, Ctr Weight & Hlth, Berkeley, CA USA.
   [Laraia, Barbara] UC Berkeley SPH, Community Hlth & Human Dev, Berkeley, CA USA.
C3 University of California System; University of California Berkeley;
   Kaiser Permanente; University of California System; University of
   California Berkeley; University of California System; University of
   California San Francisco; University of California System; University of
   California San Francisco; San Francisco General Hospital Medical Center;
   University of California System; University of California Berkeley
RP Tamayo, A (corresponding author), Univ Calif Berkeley, Berkeley Sch Publ Hlth, Div Epidemiol, 101 Haviland Hall, Berkeley, CA 94720 USA.
EM tamayo@berkeley.edu
RI Laraia, Barbara/GXG-1829-2022; Tamayo, Aracely/KHU-2891-2024; Adler,
   Nancy/ABR-3334-2022
FU National Institute of Diabetes and Digestive and Kidney Diseases [R01
   DK065664-01-A1, R01 DK080744]; National Institute of Diabetes and
   Digestive and Kidney Diseases [P30DK098722] Funding Source: NIH RePORTER
FX This study was supported by grants from the National Institute of
   Diabetes and Digestive and Kidney Diseases: "Ethnic disparities in
   diabetes complications" (PI Andrew Karter, R01 DK065664-01-A1) and
   "Neighborhood Effects on Weight Change and Diabetes Risk Factors" (PI
   Barbara Laraia, R01 DK080744).
CR [Anonymous], 2014, NAT DIAB STAT REP ES
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NR 31
TC 22
Z9 24
U1 0
U2 19
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1353-8292
EI 1873-2054
J9 HEALTH PLACE
JI Health Place
PD MAY
PY 2016
VL 39
BP 116
EP 121
DI 10.1016/j.healthplace.2016.03.007
PG 6
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA DM7DQ
UT WOS:000376515600015
PM 27060870
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Zeng, Y
   Hua, YQ
   Wang, W
   Zhang, H
   Xu, XL
AF Zeng, Yi
   Hua, Yi Qiao
   Wang, Wei
   Zhang, Hua
   Xu, Xiao Le
TI Modulation of SIRT1-mediated signaling cascades in the liver contributes
   to the amelioration of nonalcoholic steatohepatitis in high fat fed
   middle-aged LDL receptor knockout mice by dihydromyricetin
SO BIOCHEMICAL PHARMACOLOGY
LA English
DT Article
DE Nonalcoholic steatohepatitis; Dihydromyricetin; Metabolic syndrome
ID NF-KAPPA-B; MOUSE MODEL; DISEASE; SIRT1; AMPK; INFLAMMATION;
   RESVERATROL; POLYPHENOLS; METABOLISM; CROSSTALK
AB Dihydromyricetin (DMY) is the most abundant flavonoid in Ampelopsis grossedentata possessing many pharmacological activities. But less is known about its protective effect against nonalcoholic steatohepatitis (NASH) in the context of metabolic syndrome. The present study is aimed to evaluate the pharmacological effects of DMY on NASH induced by feeding a high fat diet to 12-mo-old male LDLr-/- mice for 12 weeks and its molecular mode of action. At the end of the experiment, the blood samples and liver tissues of mice were collected for analysis. The results showed that DMY treatment improved the steatosis, inflammation and fibrosis which are three main aspects of NASH and some of the metabolic basal characteristics. The underlying mechanisms include regulating key regulators of lipid metabolism, oxidative stress, inflammation and fibrosis. Notably, DMY treatment increased hepatic sirtuin 1 (SIRT1) activity and protein expression. DMY also enhanced deacetylation of liver kinase B1 (LKB1) and nuclear transcription factor kappa B (NF-kB). Furthermore, in cultured hepatocyte cells, the benefits of DMY on lipid accumulation, oxidative stress and inflammation as well as the above related genes were abrogated in hepatocytes transfected with SIRT1 siRNA. These results suggest that modulation of SIRT1-mediated signaling cascades contributes to the amelioration of NASH by DMY and DMY may serve as a potential therapeutic candidate for human NASH.
C1 [Zeng, Yi; Hua, Yi Qiao; Wang, Wei; Zhang, Hua; Xu, Xiao Le] Nantong Univ, Dept Pharmacol, Pharm Coll, Nantong 226001, Peoples R China.
   [Wang, Wei] Jiangsu Vocat Coll Med, Yancheng 224005, Peoples R China.
C3 Nantong University; Jiangsu Vocational College of Medicine
RP Xu, XL (corresponding author), Nantong Univ, Dept Pharmacol, Div Med, Med Coll, Nantong 226001, Peoples R China.
EM xiaolexu@ntu.edu.cn
FU National Science Foundation of China [81770446]; Six Talents Peak
   Project of Jiangsu Province [SWYY-022]; Nantong University Cooperative
   Innovation Program of Small Molecular Compound RD [NTU2016-1]
FX The research was supported by the National Science Foundation of China
   (Grant no. 81770446), the Six Talents Peak Project of Jiangsu Province
   (No. SWYY-022) and Nantong University Cooperative Innovation Program of
   Small Molecular Compound R&D (NTU2016-1).
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NR 40
TC 40
Z9 41
U1 2
U2 31
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0006-2952
EI 1873-2968
J9 BIOCHEM PHARMACOL
JI Biochem. Pharmacol.
PD MAY
PY 2020
VL 175
AR 113927
DI 10.1016/j.bcp.2020.113927
PG 11
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA LF3WF
UT WOS:000527350300044
PM 32217100
DA 2025-06-11
ER

PT J
AU Mallard, AR
   Ramos, JS
   Roberts, LA
   Centner, CM
   Fassett, RG
   Coombes, JS
AF Mallard, Alistair R.
   Ramos, Joyce S.
   Roberts, Llion A.
   Centner, Christoph M.
   Fassett, Robert G.
   Coombes, Jeff S.
TI The association between metabolic syndrome severity and oxidative stress
   induced by maximal exercise testing - a cross-sectional study
SO BIOMARKERS
LA English
DT Article
DE F2-isoprostanes; protein carbonyls; antioxidants; cardiorespiratory
   fitness; exercise
ID HOMEOSTASIS; BIOMARKERS; PLASMA; BLOOD; MODEL
AB Purpose: Oxidative stress (OS) has been implicated in the pathogenesis of metabolic syndrome (MetS). The acute change in OS biomarkers due to exercise, known as exercise-induced OS (EIOS), is postulated to be a more appropriate marker of OS compared to spot OS measures. These studies objectives were to investigate EIOS in participants with MetS and compare the associations between EIOS, spot OS measures and MetS severity.Methods: Sixty-three participants with MetS had MetS severity assessed using the MetS Z-score. Participants undertook a cardiorespiratory fitness test (O(2)peak) to volitional exhaustion (approximate to 8-12 minutes). Plasma OS (total F2-isoprostanes (IsoP), protein carbonyls (PCs)) and antioxidant (glutathione peroxidase (GPx), total antioxidant status (TAS)) biomarkers were measured from samples obtained before and fiveminutes post-O(2)peak test. Wilcoxon's signed-rank tests were used to determine changes in OS markers.Results: There were no significant (p>0.05) changes in OS or antioxidant biomarkers from pre- to post-exercise (median (interquartile range): IsoP -15.5 (-71.8 to 47.8) pg/mL; PC -0.01 (-0.16 to 0.13) nmol/mg protein; GPx 0.76 (-4.94 to 9.82) U/L, TAS 0.03 (0.00-0.05) mmol/L).Conclusions: A O(2)peak test to exhaustion failed to induce OS in participants with MetS. There were no associations between MetS severity and spot OS or EIOS biomarkers.
C1 [Mallard, Alistair R.; Roberts, Llion A.; Fassett, Robert G.; Coombes, Jeff S.] Univ Queensland, Ctr Res Exercise Phys Act & Hlth, Sch Human Movement Studies, Brisbane, Qld, Australia.
   [Ramos, Joyce S.] Flinders Univ S Australia, Coll Nursing & Hlth Sci, Dept Hlth & Exercise Sci, Adelaide, SA, Australia.
   [Centner, Christoph M.] Univ Freiburg, Dept Sport Sci, Freiburg, Germany.
C3 University of Queensland; Flinders University South Australia;
   University of Freiburg
RP Mallard, AR (corresponding author), Univ Queensland, Sch Human Movement & Nutr Sci, Ctr Res Exercise Phys Act & Hlth, Brisbane, Qld 4072, Australia.
EM a.mallard@uq.edu.au
RI Centner, Christoph/L-6926-2019; Fassett, Robert/R-3495-2019; Roberts,
   Llion/AAF-9393-2020; Mallard, Alistair/AAD-1147-2019; Roberts,
   Llion/E-6593-2012; Mallard, Alistair/H-4570-2014
OI Ramos, Joyce/0000-0001-8693-6800; Centner,
   Christoph/0000-0001-6839-4438; Roberts, Llion/0000-0002-2284-1033;
   Mallard, Alistair/0000-0002-7961-1458
FU Coca-Cola company
FX This study was funded by an unrestricted research grant from the from
   the Coca-Cola company. The funders had no role in the design and conduct
   of the study.
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NR 22
TC 3
Z9 3
U1 0
U2 3
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1354-750X
EI 1366-5804
J9 BIOMARKERS
JI Biomarkers
PD MAY 19
PY 2019
VL 24
IS 4
BP 394
EP 400
DI 10.1080/1354750X.2019.1600022
PG 7
WC Biotechnology & Applied Microbiology; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Toxicology
GA ID9BH
UT WOS:000471981900011
PM 30907677
DA 2025-06-11
ER

PT J
AU Wysokinski, A
AF Wysokinski, Adam
TI Fasting Serum Levels of Neuropeptide Y in Patients With Schizophrenia on
   Clozapine Monotherapy
SO CLINICAL NEUROPHARMACOLOGY
LA English
DT Review
DE schizophrenia; clozapine; NPY; metabolic syndrome
ID CORTICOTROPIN-RELEASING HORMONE; X-RAY ABSORPTIOMETRY; WEIGHT-GAIN;
   ATYPICAL ANTIPSYCHOTICS; CEREBROSPINAL-FLUID; METABOLIC SYNDROME;
   BODY-COMPOSITION; INDUCED OBESITY; DEPRESSION; GHRELIN
AB Objective: Neuropeptide Y (NPY) is one of the hypothalamic hormones that works by increasing appetite and decreasing metabolism, leading to weight gain. We checked whether NPY level in subjects with schizophrenia on clozapine is higher compared with healthy controls.
   Methods: We determined the fasting NPY levels of 24 subjects with schizophrenia on clozapine monotherapy and 24 age-and sex-matched healthy controls.
   Results: There was no difference for NPY between the clozapine group and the control group (mean [SD], 323.33 [138.50] vs 295.83 [25.28] pg/mL, P = 0.25). Neuropeptide Y was higher in women in the clozapine group (376.00 [162.15] vs 275.45 [96.99] pg/mL, P = 0.048) but not in the control group (P = 0.31) or in the whole study group (P = 0.20). We found no correlations between NPY and age, weight, body mass index, fat mass index, body circumferences, blood pressure, waist-to-hip ratio, levels of cholesterol, high-density lipoproteins, low-density lipoproteins, triglycerides, uric acid, calcium, homocysteine, glucose, insulin, insulin resistance, treatment duration, dose of clozapine, body composition, or basal metabolic rate.
   Conclusions: We cannot conclude that treatment with clozapine is associated with increased level of NPY. We did not find previously described differences in NPY for obesity or associations between NPY and metabolic parameters.
C1 Med Univ Lodz, Dept Old Age Psychiat & Psychot Disorders, PL-92216 Lodz, Poland.
C3 Medical University Lodz
RP Wysokinski, A (corresponding author), Med Univ Lodz, Dept Old Age Psychiat & Psychot Disorders, Czechoslowacka 8-10, PL-92216 Lodz, Poland.
EM adam.wysokinski@gmail.com
RI Wysokinski, Adam/S-9294-2016; Wysokinski, Adam/G-8174-2014
OI Wysokinski, Adam/0000-0002-6159-6579
FU Healthy Ageing Research Centre [REGPOT-2012-2013-1]
FX Conflicts of Interest and Source of Funding: The author is partially
   supported by Healthy Ageing Research Centre (REGPOT-2012-2013-1, 7FP).
   The author has no conflicts of interest to declare.
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NR 31
TC 6
Z9 6
U1 0
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0362-5664
EI 1537-162X
J9 CLIN NEUROPHARMACOL
JI Clin. Neuropharmacol.
PD JAN-FEB
PY 2015
VL 38
IS 1
BP 18
EP 22
DI 10.1097/WNF.0000000000000062
PG 5
WC Clinical Neurology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pharmacology & Pharmacy
GA AZ3SK
UT WOS:000348146800004
PM 25580919
DA 2025-06-11
ER

PT J
AU Rönngren, Y
   Björk, A
   Haage, D
   Audulv, A
AF Ronngren, Ylva
   Bjork, Annette
   Haage, David
   Audulv, Asa
TI Initiating and Maintaining a Lifestyle Program Directed at Persons
   Living with Severe Mental Illness in a Municipality Care Setting
SO ISSUES IN MENTAL HEALTH NURSING
LA English
DT Article
ID PHYSICAL-ACTIVITY; METABOLIC SYNDROME; EXCESS MORTALITY; HEALTH
   LITERACY; PEOPLE; INTERVENTIONS; DISORDERS; FRAMEWORK; BURDEN; REDUCE
AB Lifestyle programs are effective in improving the health of persons living with severe mental illness. However, the implementation of these programs and making them a sustainable part of daily care remain challenging. This qualitative descriptive study aimed to describe how staff worked with and experienced a lifestyle program in a municipality mental health care setting over time. The program intended to support persons living with severe mental illness to overcome health challenges. Data was collected at three time points spanning 7 years. The staff motivated the participants with SMI with severe mental illness to take part in the program, prepared them, and gave them individualized lifestyle support. A key factor of the program's implementation was the staff's interest and engagement in lifestyle questions. According to the staff it was apparent that small efforts such as running the present program could give synergic health effects such as improved mental- and social health. This study shows that it is feasible to conduct this lifestyle program in ordinary care without considerable resources. However, support from management is crucial, as well as the development of guidelines and routines of the work with lifestyle questions.
C1 [Ronngren, Ylva; Bjork, Annette; Haage, David] Mid Sweden Univ, Dept Hlth Sci, Sundsvall, Sweden.
   [Audulv, Asa] Umea Univ, Dept Nursing, Umea, Sweden.
C3 Mid-Sweden University; Umea University
RP Rönngren, Y (corresponding author), Mid Sweden Univ, Dept Hlth Sci, Sundsvall, Sweden.
EM Ylva.ronngren@miun.se
RI Audulv, Åsa K/HJO-9269-2023
OI Ronngren, Ylva/0000-0002-0002-7866
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NR 50
TC 1
Z9 1
U1 0
U2 0
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 0161-2840
EI 1096-4673
J9 ISSUES MENT HEALTH N
JI Issues Ment. Health Nurs.
PD JUL 2
PY 2024
VL 45
IS 7
BP 706
EP 714
DI 10.1080/01612840.2024.2344805
EA APR 2024
PG 9
WC Nursing; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Psychiatry
GA YL7T9
UT WOS:001216417000001
PM 38717866
OA hybrid
DA 2025-06-11
ER

PT J
AU Barbhuiya, PA
   Pathak, MP
AF Barbhuiya, Pervej Alom
   Pathak, Manash Pratim
TI Impact of Obesity, Menopause, and Depression in Women's Health:An
   Attempt to Decipher the Complex Relationship
SO CURRENT MEDICINAL CHEMISTRY
LA English
DT Review; Early Access
DE Obesity; menopause; depression; estrogen; women's health; phytoestrogens
ID GENOME-WIDE ASSOCIATION; BODY-MASS INDEX; POSTMENOPAUSAL WOMEN; HOT
   FLASHES; VISCERAL FAT; REPRODUCTIVE HORMONES; METABOLIC SYNDROME;
   PHYSICAL-ACTIVITY; ADIPOSE-TISSUE; MIDLIFE WOMEN
AB Background: Menopause symptoms may be distressing, especially when they appear at a time when women are expected to play significant responsibilities in society. Numerous biological systems are influenced by the hormonal changes that start during the menopausal transition. This review attempts to decipher the complex relationship between obesity, menopause, and depression, citing some recent longitudinal and cross-sectional studies. Additionally, this study provides a summary of the different phytoestrogens, their sources, and probable mechanisms of action in addition to available therapeutic alternatives. Methodology: For this review purpose, the authors have gone through a vast number of articles from various scientific databases like PubMed, Google Scholar, and Web of Science. Results: It is becoming clear that the physiological basis for these menopausal symptoms is complicated and connected to estrogen deficiency, but not alone. Other hormones like FSH, LH, progesterone, and inhibin B are the major ones that are both directly and indirectly responsible for most of the menopausal symptoms. Numerous longitudinal and cross-sectional studies have found a direct relationship between the incidence of menopause and depression as well as obesity. Phytoestrogens like stilbene, lignans, isoflavone, and coumestan have been reported to be the alternatives to synthetic estrogen with lesser side effects, as reported in various studies. Conclusion: The complex relationship between depression, menopause, and obesity presents a complex obstacle to women's health and overall well-being. There might be a lot of promising prospects for revolutionary advancements in women's health during the menopausal stage in the future. Promising drug development that targets not just one but also the three conditions -obesity, menopause, and depression - as well as more thorough research are needed to improve the healthcare system for women who suffer from these conditions.
C1 [Barbhuiya, Pervej Alom; Pathak, Manash Pratim] Assam Down Town Univ, Fac Pharmaceut Sci, Sankar Madhab Path, Gauhati 781026, Assam, India.
   [Barbhuiya, Pervej Alom; Pathak, Manash Pratim] Assam Down Town Univ, Ctr Res Ethnomed, Sankar Madhab Path, Gauhati 781026, Assam, India.
C3 Assam Down Town University; Assam Down Town University
RP Pathak, MP (corresponding author), Assam Down Town Univ, Fac Pharmaceut Sci, Sankar Madhab Path, Gauhati 781026, Assam, India.
EM manashpharma@rediffmail.com
RI Pathak, Manash/I-3539-2019
FU Assam down town University, Guwahati, India [AdtU/DRA-II/2023-24/156]
FX The authors are thankful to Assam down town University, Guwahati, India,
   for providing financial support in the form of a Seed Money Grant vide
   award letter number AdtU/DRA-II/2023-24/156.
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NR 144
TC 0
Z9 0
U1 3
U2 3
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 0929-8673
EI 1875-533X
J9 CURR MED CHEM
JI Curr. Med. Chem.
PD 2024 OCT 16
PY 2024
DI 10.2174/0109298673317600240930052201
EA OCT 2024
PG 22
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Pharmacology &
   Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
GA J6C1F
UT WOS:001337914500001
PM 39415576
DA 2025-06-11
ER

PT J
AU van den Heuvel, LL
   Smit, AM
   Stalder, T
   Kirschbaum, C
   Seedat, S
   Emsley, R
AF van den Heuvel, Leigh Luella
   Smit, Anna Margaretha
   Stalder, Tobias
   Kirschbaum, Clemens
   Seedat, Soraya
   Emsley, Robin
TI Hair cortisol levels in schizophrenia and metabolic syndrome
SO EARLY INTERVENTION IN PSYCHIATRY
LA English
DT Article
DE cardiovascular disease; first-episode psychosis; hydrocortisone;
   hypothalamic-pituitary-adrenal axis; stress
ID PITUITARY-ADRENAL AXIS; BIPOLAR DISORDER; DRUG-NAIVE; STRESS;
   1ST-EPISODE; MORTALITY; DISEASE; METAANALYSIS; VALIDATION; PSYCHOSIS
AB Aim Individuals with schizophrenia demonstrate higher rates of metabolic syndrome (MetS) than the general population. Hair cortisol concentrations (HCC) reflect longer-term cortisol secretion and can provide additional insights into the role of the hypothalamic pituitary adrenal (HPA) axis in schizophrenia and co-occurring MetS. Methods In a case-control study of 16 patients with schizophrenia (11 first episode psychosis [FEP] and 5 chronic) and 21 controls hair samples, representing a 3-month retrospective window of cortisol, were collected and analysed utilizing liquid chromatography tandem mass spectrometry. We investigated whether schizophrenia and MetS co-occurrence were associated with HCC utilizing multivariate regression models. We also explored the longitudinal trajectory of HCC in FEP patients by conducting a mixed models analysis. Results At baseline HCC were significantly lower (Cohen's d = 0.88) in patients with schizophrenia than in controls (p = .014). HCC increased from baseline to month-12 in FEP patients compared to controls, demonstrating a trend towards significance (p = .097). MetS was not associated with HCC at baseline, but HCC increased significantly from baseline to month-12 in relation to MetS (p = .037). Conclusions In a subgroup of schizophrenia patients, psychosis may be associated with a blunted HPA axis with lower long-term cortisol output. MetS was associated with an increase in HCC and elevated cortisol levels observed in schizophrenia may be related to increased rates of MetS in schizophrenia patients.
C1 [van den Heuvel, Leigh Luella; Smit, Anna Margaretha; Seedat, Soraya; Emsley, Robin] Stellenbosch Univ, Dept Psychiat, Fac Med & Hlth Sci, Clin Bldg,POB 241, ZA-8000 Tygerberg, South Africa.
   [van den Heuvel, Leigh Luella; Seedat, Soraya; Emsley, Robin] Stellenbosch Univ, Fac Med & Hlth Sci, Genom Brain Disorders Res Unit, South African Med Res Council, Cape Town, South Africa.
   [Stalder, Tobias] Univ Siegen, Clin Psychol, Siegen, Germany.
   [Kirschbaum, Clemens] Tech Univ Dresden, Biol Psychol, Dresden, Germany.
C3 Stellenbosch University; Stellenbosch University; South African Medical
   Research Council; Universitat Siegen; Technische Universitat Dresden
RP van den Heuvel, LL (corresponding author), Stellenbosch Univ, Dept Psychiat, Fac Med & Hlth Sci, Clin Bldg,POB 241, ZA-8000 Tygerberg, South Africa.
EM llvdh@sun.ac.za
RI Kirschbaum, Clemens/AAB-1752-2020; van den Heuvel, Leigh/AGV-5481-2022
OI , Clemens/0000-0003-3707-4444; Stalder, Tobias/0000-0001-7558-1274;
   Smit, Anna Margaretha/0000-0003-3966-5213; van den Heuvel,
   Leigh/0000-0003-3884-4754; Seedat, Soraya/0000-0002-5118-786X
FU Deutsche Forschungsgemeinschaft [KI-537/37-1, STA 1213/6-1]; South
   African Department of Science and Technology; South African National
   Research Foundation; South African Research Chairs Initiative in PTSD;
   South African Medical Research Council [MRC-RFA-IFSP-01-2013]
FX Deutsche Forschungsgemeinschaft, Grant/Award Numbers: KI-537/37-1, STA
   1213/6-1; South African Department of Science and Technology and the
   South African National Research Foundation; South African Research
   Chairs Initiative in PTSD; South African Medical Research Council,
   Grant/Award Numbers: SAMRC CLINICIAN RESEARCHER (M.D PHD) SCHOLARSHIP
   PROGRAMME, MRC-RFA-IFSP-01-2013/SHARED ROOTS genetic risk (Laursen et
   al., 2014; Penninx & Lange, 2018; Vancampfort et al., 2015).
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NR 43
TC 10
Z9 10
U1 2
U2 14
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1751-7885
EI 1751-7893
J9 EARLY INTERV PSYCHIA
JI Early Interv. Psychiatry
PD AUG
PY 2022
VL 16
IS 8
BP 902
EP 911
DI 10.1111/eip.13238
EA JAN 2022
PG 10
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 3L6EZ
UT WOS:000737152400001
PM 34978366
DA 2025-06-11
ER

PT J
AU Vehkala, L
   Ukkola, O
   Kesäniemi, YA
   Kähönen, M
   Nieminen, MS
   Salomaa, V
   Jula, A
   Hörkkö, S
AF Vehkala, Lauri
   Ukkola, Olavi
   Kesaniemi, Y. Antero
   Kahonen, Mika
   Nieminen, Markku S.
   Salomaa, Veikko
   Jula, Antti
   Horkko, Sohvi
TI Plasma IgA antibody levels to malondialdehyde acetaldehyde-adducts are
   associated with inflammatory mediators, obesity and type 2 diabetes
SO ANNALS OF MEDICINE
LA English
DT Article
DE CRP; glucose metabolism; oxidized LDL; TNF-alpha
ID LOW-DENSITY-LIPOPROTEIN; CIRCULATING OXIDIZED LDL;
   NECROSIS-FACTOR-ALPHA; INSULIN-RESISTANCE; METABOLIC SYNDROME; OXIDATIVE
   STRESS; PROTEIN ADDUCTS; IMMUNE-SYSTEM; ATHEROSCLEROSIS; AUTOANTIBODIES
AB Aim. Obesity and type 2 diabetes (T2D) associate with increased oxidative stress. Malondialdehyde acetaldehyde (MAA) adducts have been suggested to be one of the antigenic epitopes in MDA-LDL responsible for the antibody recognition. Our aim was to investigate the associations between plasma IgA antibodies to MAA-LDL, inflammatory markers, adipokines, obesity, and T2D.
   Methods. IgA to MAA-LDL were measured in a subsample (n = 1507) of the Finnish Health 2000 survey. The associations between antibody levels, obesity, TNF-alpha, IL-6, high-sensitivity (hs) CRP, resistin, adiponectin, fasting plasma (fp) glucose, fp-insulin, glycosylated hemoglobin (Hb-A1C), and T2D were investigated.
   Results. IgA to MAA-LDL associated positively with fasting plasma insulin. IgA to MAA-LDL were higher among subjects with T2D (P < 0.001) compared to subjects with normal glucose metabolism. IgA to MAA-LDL associated with obesity, but was not independently (P = 0.002, not significant after correction for multiple tests) associated with T2D in logistic regression analysis. IgA to MAA-LDL, obesity, and TNF-alpha all associated with markers of glucose metabolism.
   Conclusions. T2D subjects had increased IgA to MAA-LDL compared to subjects with normal glucose metabolism. The data suggest that the associations between IgA to MAA-LDL and markers of glucose metabolism were independent of TNF-alpha but dependent on components of the metabolic syndrome.
C1 [Vehkala, Lauri; Horkko, Sohvi] Univ Oulu, Inst Diagnost, Dept Med Microbiol & Immunol, FI-90014 Oulu, Finland.
   [Vehkala, Lauri; Horkko, Sohvi] Med Res Ctr, Oulu, Finland.
   [Ukkola, Olavi; Kesaniemi, Y. Antero] Univ Oulu, Bioctr Oulu, FI-90014 Oulu, Finland.
   [Vehkala, Lauri; Ukkola, Olavi; Kesaniemi, Y. Antero; Horkko, Sohvi] Oulu Univ Hosp, Nordlab Oulu, Oulu, Finland.
   [Kahonen, Mika] Tampere Univ Hosp, Dept Clin Physiol, Tampere, Finland.
   [Kahonen, Mika] Univ Tampere, FIN-33101 Tampere, Finland.
   [Nieminen, Markku S.] Univ Helsinki, Dept Med, Helsinki, Finland.
   [Salomaa, Veikko] Natl Inst Hlth & Welf, Dept Chron Dis Prevent, Helsinki, Finland.
   [Jula, Antti] Natl Inst Hlth & Welf, Dept Chron Dis Prevent, Helsinki, Finland.
C3 University of Oulu; University of Oulu; University of Oulu; Tampere
   University; Tampere University Hospital; Tampere University; University
   of Helsinki; Finland National Institute for Health & Welfare; Finland
   National Institute for Health & Welfare
RP Hörkkö, S (corresponding author), Univ Oulu, Inst Diagnost, Dept Med Microbiol & Immunol, Oulu POB 5000, FI-90014 Oulu, Finland.
EM sohvi.horkko@oulu.fi
RI Gratten, Jacob/G-1485-2011; Salomaa, Veikko/AEO-8209-2022
OI Kahonen, Mika/0000-0002-4510-7341
FU Academy of Finland; Sigrid Juselius Foundation; Finnish Foundation for
   Cardiovascular Research; Sohlberg Foundation; Medical Research Fund of
   Tampere University Hospital; Finnish Cultural Foundation
FX The authors report no conflicts of interest. This work was supported by
   funding from the Academy of Finland, the Sigrid Juselius Foundation, the
   Finnish Foundation for Cardiovascular Research, the Sohlberg Foundation,
   the Medical Research Fund of Tampere University Hospital, and the
   Finnish Cultural Foundation.
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U1 0
U2 6
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0785-3890
EI 1365-2060
J9 ANN MED
JI Ann. Med.
PD DEC
PY 2013
VL 45
IS 8
BP 501
EP 510
DI 10.3109/07853890.2013.841322
PG 10
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 255RO
UT WOS:000327257700002
PM 24131174
OA Bronze
DA 2025-06-11
ER

PT J
AU Mallorquí-Bagué, N
   Lozano-Madrid, M
   Vintró-Alcaraz, C
   Forcano, L
   Díaz-López, A
   Galera, A
   Fernández-Carrión, R
   Granero, R
   Jiménez-Murcia, S
   Corella, D
   Pintó, X
   Cuenca-Royo, A
   Bulló, M
   Salas-Salvadó, J
   de la Torre, R
   Fernández-Aranda, F
AF Mallorqui-Bague, Nuria
   Lozano-Madrid, Maria
   Vintro-Alcaraz, Cristina
   Forcano, Laura
   Diaz-Lopez, Andres
   Galera, Ana
   Fernandez-Carrion, Rebeca
   Granero, Roser
   Jimenez-Murcia, Susana
   Corella, Dolores
   Pinto, Xavier
   Cuenca-Royo, Aida
   Bullo, Monica
   Salas-Salvado, Jordi
   de la Torre, Rafael
   Fernandez-Aranda, Fernando
TI Effects of a psychosocial intervention at one-year follow-up in a
   PREDIMED-plus sample with obesity and metabolic syndrome
SO SCIENTIFIC REPORTS
LA English
DT Article
ID IMPULSIVE BEHAVIOR SCALE; FOOD ADDICTION; PHYSICAL-ACTIVITY; GAMBLING
   DISORDER; EATING-DISORDERS; SPANISH VERSION; DEPRESSION; RISK; DIET;
   ASSOCIATION
AB This study examines if overweight/obesity are related to higher impulsivity, food addiction and depressive symptoms, and if these variables could be modified after 1 year of a multimodal intervention (diet, physical activity, psychosocial support). 342 adults (55-75 years) with overweight/obesity and metabolic syndrome (MetS) from the PREDIMED-Plus Cognition study were randomized to the intervention or to the control group (lifestyle recommendations). Cognitive and psychopathological assessments were performed at baseline and after 1-year follow-up. At baseline, higher impulsivity was linked to higher food addiction and depressive symptoms, but not to body mass index (BMI). Food addiction not only predicted higher BMI and depressive symptoms, but also achieved a mediational role between impulsivity and BMI/depressive symptoms. After 1 year, patients in both groups reported significant decreases in BMI, food addiction and impulsivity. BMI reduction and impulsivity improvements were higher in the intervention group. Higher BMI decrease was achieved in individuals with lower impulsivity. Higher scores in food addiction were also related to greater post-treatment impulsivity. To conclude, overweight/obesity are related to higher impulsivity, food addiction and depressive symptoms in mid/old age individuals with MetS. Our results also highlight the modifiable nature of the studied variables and the interest of promoting multimodal interventions within this population.
C1 [Mallorqui-Bague, Nuria] Hosp Santa Creu & Sant Pau, Addict Behav Unit, Dept Psychiat, Biomed Res Inst St Pau IIB St Pau, Barcelona, Spain.
   [Mallorqui-Bague, Nuria; Lozano-Madrid, Maria; Vintro-Alcaraz, Cristina; Jimenez-Murcia, Susana; Fernandez-Aranda, Fernando] Univ Hosp Bellvitge IDIBELL, Dept Psychiat, Feixa Llarga S-N, Barcelona 08907, Spain.
   [Mallorqui-Bague, Nuria; Lozano-Madrid, Maria; Vintro-Alcaraz, Cristina; Forcano, Laura; Diaz-Lopez, Andres; Galera, Ana; Fernandez-Carrion, Rebeca; Granero, Roser; Jimenez-Murcia, Susana; Corella, Dolores; Pinto, Xavier; Cuenca-Royo, Aida; Bullo, Monica; Salas-Salvado, Jordi; de la Torre, Rafael; Fernandez-Aranda, Fernando] Inst Salud Carlos III ISCIII, Consorcio CIBER, MP Fisiopatol Obesidad & Nutr CIBERObn, Madrid, Spain.
   [Forcano, Laura; Cuenca-Royo, Aida; de la Torre, Rafael] Inst Hosp del Mar Invest Med IMIM, Integrat Pharmacol & Neurosci Syst, Dr Aiguder 88, Barcelona 08003, Spain.
   [Diaz-Lopez, Andres; Bullo, Monica; Salas-Salvado, Jordi] Univ Rovira & Virgili, Dept Bioquim & Biotecnol, Unitat Nutr Humana, Reus, Spain.
   [Galera, Ana; Pinto, Xavier] Univ Hosp Bellvitge, Lipids & Vasc Risk Unit, Internal Med, Barcelona, Spain.
   [Fernandez-Carrion, Rebeca; Corella, Dolores] Univ Valencia, Dept Prevent Med, Valencia, Spain.
   [Granero, Roser] Univ Autonoma Barcelona, Dept Psicobiol & Metodol, Barcelona, Spain.
   [Jimenez-Murcia, Susana; Fernandez-Aranda, Fernando] Univ Barcelona, Sch Med & Hlth Sci, Dept Clin Sci, Barcelona, Spain.
   [Diaz-Lopez, Andres; Bullo, Monica; Salas-Salvado, Jordi] Inst Invest Sanitaria Pere Virgili IISPV, Reus, Spain.
   [Salas-Salvado, Jordi] Univ Hosp St Joan Reus, Nutr Unit, Reus, Spain.
   [de la Torre, Rafael] Univ Pompeu Fabra CEXS UPF, Dept Ciencies Expt & Salut, Barcelona, Spain.
   [Diaz-Lopez, Andres] Univ Rovira & Virgili URV, Reus, Spain.
C3 Hospital of Santa Creu i Sant Pau; Institut d'Investigacio Biomedica de
   Bellvitge (IDIBELL); Bellvitge University Hospital; University of
   Barcelona; Hospital del Mar Research Institute; Hospital del Mar;
   Universitat Rovira i Virgili; Institut d'Investigacio Biomedica de
   Bellvitge (IDIBELL); Bellvitge University Hospital; University of
   Barcelona; University of Valencia; Autonomous University of Barcelona;
   University of Barcelona; Universitat Rovira i Virgili; Institut
   d'Investigacio Sanitaria Pere Virgili (IISPV); Pompeu Fabra University;
   Universitat Rovira i Virgili
RP Fernández-Aranda, F (corresponding author), Univ Hosp Bellvitge IDIBELL, Dept Psychiat, Feixa Llarga S-N, Barcelona 08907, Spain.; de la Torre, R; Fernández-Aranda, F (corresponding author), Inst Salud Carlos III ISCIII, Consorcio CIBER, MP Fisiopatol Obesidad & Nutr CIBERObn, Madrid, Spain.; de la Torre, R (corresponding author), Inst Hosp del Mar Invest Med IMIM, Integrat Pharmacol & Neurosci Syst, Dr Aiguder 88, Barcelona 08003, Spain.; Fernández-Aranda, F (corresponding author), Univ Barcelona, Sch Med & Hlth Sci, Dept Clin Sci, Barcelona, Spain.; de la Torre, R (corresponding author), Univ Pompeu Fabra CEXS UPF, Dept Ciencies Expt & Salut, Barcelona, Spain.
EM RTorre@imim.es; ffernandez@bellvitgehospital.cat
RI Corella, Dolores/L-9888-2014; FORCANO, LAURA/AAP-1933-2020;
   Mallorquí-Bagué, Núria/Q-1721-2015; Torre, Riccardo/N-9558-2014;
   Fernandez-Carrion, Rebeca/AAA-5713-2019; Pintó, Xavier/AGI-4297-2022;
   JIMENEZ-MURCIA, SUSANA/L-9786-2014; Salas-Salvado, Jordi/C-7229-2017;
   Lozano Madrid, Maria/IQV-7373-2023; Forcano Gamazo, Laura/B-1154-2017;
   Vintro Alcaraz, Cristina/R-7030-2018; Bullo, Monica/F-2925-2016;
   Granero, Roser/F-9492-2016; FERNANDEZ-ARANDA, FERNANDO/L-9762-2014
OI JIMENEZ-MURCIA, SUSANA/0000-0002-3596-8033; Salas-Salvado,
   Jordi/0000-0003-2700-7459; Lozano Madrid, Maria/0000-0003-3833-317X;
   Forcano Gamazo, Laura/0000-0002-8478-1451; Cuenca Royo,
   Aida/0000-0001-8551-5457; Vintro Alcaraz, Cristina/0000-0001-9453-8810;
   Diaz-Lopez, Andres/0000-0002-7500-5629; Bullo,
   Monica/0000-0002-0218-7046; Granero, Roser/0000-0001-6308-3198;
   FERNANDEZ-ARANDA, FERNANDO/0000-0002-2968-9898
FU Department of Health of the Generalitat de Catalunya [SLT006/17/00246,
   SLT002/16/00045]; Instituto de Salud Carlos III (ISCIII); Spanish
   Government Official Agency through the Fondo de Investigacion para la
   Salud (FIS); European Regional Development Fund [PI13/00233, PI13/00728,
   PI13/01123, PI13/00462, PI16/00533, PI16/00366, PI16/01094, PI16/00501,
   PI19/00017, PI19/00781, PI19/01032, PI19/00576]; Especial Action
   Project; European Research Council [340918]; Recercaixa [2013ACUP00194];
   EU-H2020 Grants [Eat2beNICE/H2020-SFS-2016-2, 728018,
   PRIME/H2020-SC1-BHC-2018-2020, 847879]; Instituto Salud Carlos III
   (Fondo Investigacion Sanitario, FIS) [PI17/01167]; Generalitat
   Valenciana [PROMETEO/2017/017]; Grant FEA/SEA; ICREA under the ICREA
   Academia programme; Ministerio de Educacion, Cultura y Deporte
   [FPU15/02911, FPU16/01453]; DIUE de la Generalitat de Catalunya from the
   Departament d'Economia i Coneixement de la Generalitat de Catalunya
   (Spain) [2017 SGR 138]
FX Study resulting from the following grants: SLT006/17/00246 and
   SLT002/16/00045, funded by the Department of Health of the Generalitat
   de Catalunya by the calls "Accio instrumental de programes de recerca
   orientats en l'ambit de la recerca i la innovacio en salut" and "Pla
   estrategic de recerca i innovacio en salut (PERIS)". We thank CERCA
   Programme/Generalitat de Catalunya for institutional support. This
   project was funded by Instituto de Salud Carlos III (ISCIII), the
   Spanish Government Official Agency for funding biomedical research-with
   competitive grants leaded by Jordi Salas-Salvado and Josep Vidal for the
   periods 2014-2016, 2015-2017, 2017-2019 and 2018-2020, through the Fondo
   de Investigacion para la Salud (FIS), which is co-funded by the European
   Regional Development Fund [grants: PI13/00233, PI13/00728, PI13/01123,
   PI13/00462, PI16/00533, PI16/00366, PI16/01094, PI16/00501, PI19/00017,
   PI19/00781, PI19/01032, PI19/00576]; the Especial Action Project
   entitled: Implementacion y evaluacion de una intervencion intensiva
   sobre la actividad fisica Cohorte PREDIMED-Plus grant to Jordi
   Salas-Salvado; the European Research Council [Advanced Research Grant
   2014-2019; agreement #340918] granted to Miguel Angel Martinez-Gonzalez;
   the Recercaixa (number 2013ACUP00194) grant to Jordi Salas-Salvado. This
   research was also partially funded by EU-H2020 Grants
   (Eat2beNICE/H2020-SFS-2016-2; Ref 728018; and
   PRIME/H2020-SC1-BHC-2018-2020; Ref: 847879) and Instituto Salud Carlos
   III (Fondo Investigacion Sanitario, FIS: PI17/01167), Grant
   PROMETEO/2017/017 (Generalitat Valenciana) and Grant FEA/SEA 2017 for
   Primary Care Research. This work is also partially supported by ICREA
   under the ICREA Academia programme. None of these funding sources plays
   any role in the design, collection, analysis, or interpretation of the
   data or in the decision to submit manuscripts for publication. MLM and
   CVA are supported by a predoctoral Grant of the Ministerio de Educacion,
   Cultura y Deporte (FPU15/02911 and FPU16/01453). This work was supported
   by grants from DIUE de la Generalitat de Catalunya 2017 SGR 138 (RTF)
   from the Departament d'Economia i Coneixement de la Generalitat de
   Catalunya (Spain). The funders of the study had no role in study design,
   data collection, data analysis, data interpretation, or writing of the
   report.
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NR 93
TC 12
Z9 12
U1 1
U2 12
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD APR 28
PY 2021
VL 11
IS 1
AR 9144
DI 10.1038/s41598-021-88298-1
PG 12
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Science & Technology - Other Topics
GA SK2NW
UT WOS:000656057700003
PM 33911087
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Rönngren, YM
   Björk, A
   Haage, D
   Kristiansen, L
AF Ronngren, Y. M.
   Bjork, A.
   Haage, D.
   Kristiansen, L.
TI LIFEHOPE.EU: lifestyle and healthy outcome in physical education
SO JOURNAL OF PSYCHIATRIC AND MENTAL HEALTH NURSING
LA English
DT Article
DE cognitive adaptive training; cognitive disabilities; lifestyle
   intervention programme; nursing care; physical activity; severe mental
   illness
ID QUALITY-OF-LIFE; MENTAL-ILLNESS; METABOLIC SYNDROME; PEOPLE; STATE;
   SCHIZOPHRENIA; INTERVENTIONS; INDIVIDUALS; PREVALENCE; DEFICITS
AB People with severe mental illness (SMIs) are more prone to physical illnesses, increased mortality and cognitive impairments, all of which negatively influence their daily lives. Physical activity (PHYS) programmes have helped alleviate SMI. LIFEHOPE is an ongoing research project with the purpose of developing a sustainable lifestyle intervention for physical and mental health. PHYS/cognitive adaptation training (CAT) is a newly created lifestyle intervention that provides group education and is based on CAT. It provides individualized support for PHYS and dietary change in a natural nursing environment. The aim of this study was to obtain further knowledge for developing a sustainable lifestyle programme by exploring psychiatric clients' experiences with PHYS and lifestyle habits, which we did by interviewing a local reference group, community mental healthcare users and community mental healthcare workers. Then, we developed a lifestyle programme for people with SMI using information obtained from these focus group interviews. Our results suggest that there is a need for support and education, as well as active interventions, in carrying out PHYS and dietary changes among people with SMIs, and the PHYS/CAT may be a useful strategy.
C1 [Ronngren, Y. M.; Bjork, A.; Haage, D.; Kristiansen, L.] Mid Sweden Univ, Dept Nursing, SE-85170 Sundsvall, Sweden.
C3 Mid-Sweden University
RP Rönngren, YM (corresponding author), Mid Sweden Univ, Dept Nursing Sci, Dept Nursing, Holmgatan 10, SE-85170 Sundsvall, Sweden.
EM ylva.ronngren@miun.se
OI Kristiansen, Lisbeth/0000-0001-7959-606X
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NR 46
TC 8
Z9 9
U1 0
U2 10
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1351-0126
EI 1365-2850
J9 J PSYCHIATR MENT HLT
JI J. Psychiatr. Ment. Health Nurs.
PD DEC
PY 2014
VL 21
IS 10
BP 924
EP 930
DI 10.1111/jpm.12175
PG 7
WC Nursing; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Psychiatry
GA AU0OE
UT WOS:000345321900010
PM 25236866
DA 2025-06-11
ER

PT J
AU Chen, DD
   Zhang, H
   Wu, JJ
   Xue, ER
   Guo, PP
   Tang, LW
   Shao, J
   Cui, NQ
   Wang, XY
   Chen, LY
   Ye, ZH
AF Chen, Dandan
   Zhang, Hui
   Wu, Jingjie
   Xue, Erxu
   Guo, Pingping
   Tang, Leiwen
   Shao, Jing
   Cui, Nianqi
   Wang, Xiyi
   Chen, Liying
   Ye, Zhihong
TI Effects of an Individualized mHealth-Based Intervention on Health
   Behavior Change and Cardiovascular Risk Among People With Metabolic
   Syndrome Based on the Behavior Change Wheel: Quasi-Experimental Study
SO JOURNAL OF MEDICAL INTERNET RESEARCH
LA English
DT Article
DE metabolic syndrome; health behavior; cardiovascular risk; mobile health;
   behavior change wheel
ID PREVENTION; PREVALENCE; MANAGEMENT; REDUCE
AB Background: Metabolic syndrome (MetS) is a common public health challenge. Health-promoting behaviors such as diet and physical activity are central to preventing and controlling MetS. However, the adoption of diet and physical activity behaviors has always been challenging. An individualized mobile health (mHealth)-based intervention using the Behavior Change Wheel is promising in promoting health behavior change and reducing atherosclerotic cardiovascular disease (ASCVD) risk. However, the effects of this intervention are not well understood among people with MetS in mainland China.Objective: We aimed to evaluate the effects of the individualized mHealth-based intervention using the Behavior Change Wheel on behavior change and ASCVD risk in people with MetS.
   Methods: We conducted a quasi-experimental, nonrandomized study. Individuals with MetS were recruited from the health promotion center of a tertiary hospital in Zhejiang province, China. The study involved 138 adults with MetS, comprising a control group of 69 participants and an intervention group of 69 participants. All participants received health education regarding diet and physical activity. The intervention group additionally received a 12-week individualized intervention through a WeChat mini program and a telephone follow-up in the sixth week of the intervention. Primary outcomes included diet, physical activity behaviors, and ASCVD risk. Secondary outcomes included diet self-efficacy, physical activity self-efficacy, knowledge of MetS, quality of life, and the quality and efficiency of health management services. The Mann-Whitney U test and Wilcoxon signed rank test were primarily used for data analysis. Data analysis was conducted based on the intention-to-treat principle using SPSS (version 25.0; IBM Corp).
   Results: Baseline characteristics did not differ between the 2 groups. Compared with the control group, participants in the intervention group showed statistically significant improvements in diet behavior, physical activity behavior, diet self-efficacy, physical activity self-efficacy, knowledge of MetS, physical health, and mental health after a 12-week intervention (P=.04, P=.001, P=.04, P=.04, P=.001, P=.04, P=.04, and P<.05). The intervention group demonstrated a statistically significant improvement in outcomes from pre-to postintervention evaluations (P<.001, P=.03, P<.001, P=.04, P<.001, P<.001, and P<.001). The intervention also led to enhanced health management services and quality.
   Conclusions: The individualized mHealth-based intervention using the Behavior Change Wheel was effective in promoting diet and physical activity behaviors in patients with MetS. Nurses and other health care professionals may incorporate the intervention into their health promotion programs.
C1 [Chen, Dandan; Wu, Jingjie; Xue, Erxu; Chen, Liying; Ye, Zhihong] Zhejiang Univ, Affiliated Sir Run Run Shaw Hosp, Nursing Dept, Sch Med, Hangzhou, Peoples R China.
   [Zhang, Hui] Guizhou Prov Peoples Hosp, Dept Nursing, Guiyang, Peoples R China.
   [Guo, Pingping] Zhejiang Univ, Nursing Dept, Sch Med, Womens Hosp, Hangzhou, Peoples R China.
   [Tang, Leiwen] Zhejiang Univ, Inst Nursing Res, Sch Med, Hangzhou, Peoples R China.
   [Shao, Jing] Zhejiang Univ, Dept Nursing, Affiliated Hosp 4, Sch Med,Inst Nursing Res, Yiwu, Peoples R China.
   [Cui, Nianqi] Kunming Med Univ, Sch Nursing, Kunming, Peoples R China.
   [Wang, Xiyi] Shanghai Jiao Tong Univ, Sch Nursing, Shanghai, Peoples R China.
   [Ye, Zhihong] Zhejiang Univ, Affiliated Sir Run Run Shaw Hosp, Sch Med, Nursing Dept, 3 East Qingchun Rd, Hangzhou 310020, Peoples R China.
C3 Zhejiang University; Zhejiang University; Zhejiang University; Zhejiang
   University; Kunming Medical University; Shanghai Jiao Tong University;
   Zhejiang University
RP Ye, ZH (corresponding author), Zhejiang Univ, Affiliated Sir Run Run Shaw Hosp, Sch Med, Nursing Dept, 3 East Qingchun Rd, Hangzhou 310020, Peoples R China.
EM yezh@zju.edu.cn
RI Wu, Jingjie/G-8274-2016; Wang, Xiyi/AAQ-2610-2021
OI Guo, Pingping/0000-0002-5091-9387; Wang, Xiyi/0000-0002-6470-8556; Tang,
   Leiwen/0000-0003-4058-0161; Cui, Nianqi/0000-0002-7963-4887
FU National Social Science Fund of China [20BGL275]
FX Acknowledgments The authors express their sincere gratitude to the
   participating hospital and all individuals with metabolic syndrome. This
   study was supported by the National Social Science Fund of China
   (20BGL275) . Generative artificial intelligence was not used in any
   portion of the manuscript writing.
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NR 62
TC 4
Z9 4
U1 3
U2 32
PU JMIR PUBLICATIONS, INC
PI TORONTO
PA 130 QUEENS QUAY East, Unit 1100, TORONTO, ON M5A 0P6, CANADA
SN 1438-8871
J9 J MED INTERNET RES
JI J. Med. Internet Res.
PD NOV 29
PY 2023
VL 25
AR e49257
DI 10.2196/49257
PG 17
WC Health Care Sciences & Services; Medical Informatics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Health Care Sciences & Services; Medical Informatics
GA AA1L0
UT WOS:001115638000001
PM 38019579
OA gold
DA 2025-06-11
ER

PT J
AU dos Santos, JL
   de Quadros, A
   Weschenfelder, C
   Garofallo, SB
   Marcadenti, A
AF dos Santos, Julia Lorenzon
   de Quadros, Alexandre Schaan
   Weschenfelder, Camila
   Garofallo, Silvia Bueno
   Marcadenti, Aline
TI Oxidative Stress Biomarkers, Nut-Related Antioxidants, and
   Cardiovascular Disease
SO NUTRIENTS
LA English
DT Review
DE oxidative stress; antioxidants; nuts; cardiovascular diseases
ID CORONARY-HEART-DISEASE; CHEMICAL-COMPOSITION; METABOLIC SYNDROME;
   PISTACHIO NUTS; NITRIC-OXIDE; VITAMIN-E; CONSUMPTION; INFLAMMATION;
   BRAZIL; ALMONDS
AB Atherosclerosis is related to fat accumulation in the arterial walls and vascular stiffening, and results in acute coronary syndrome which is commonly associated with acute myocardial infarction. Oxidative stress participates in the pathogenesis of atherosclerosis. Thus, the inclusion of food sources of dietary antioxidants, such as different kinds of nuts, may improve biomarkers related to oxidative stress, contributing to a possible reduction in atherosclerosis progression. This article has briefly highlighted the interaction between oxidative stress, atherosclerosis, and cardiovascular disease, in addition to the effect of the consumption of different nuts and related dietary antioxidants-like polyphenols and vitamin E-on biomarkers of oxidative stress in primary and secondary cardiovascular prevention. Studies in vitro suggest that nuts may exert antioxidant effects by DNA repair mechanisms, lipid peroxidation prevention, modulation of the signaling pathways, and inhibition of the MAPK pathways through the suppression of NF-kappa B and activation of the Nrf2 pathways. Studies conducted in animal models showed the ability of dietary nuts in improving biomarkers of oxidative stress, such as oxLDL and GPx. However, clinical trials in humans have not been conclusive, especially with regards to the secondary prevention of cardiovascular disease.
C1 [dos Santos, Julia Lorenzon; de Quadros, Alexandre Schaan; Weschenfelder, Camila; Garofallo, Silvia Bueno; Marcadenti, Aline] Univ Fdn Cardiol IC FUC, Inst Cardiol Rio Grande Sul, Grad Program Hlth Sci Cardiol, Princesa Isabel Ave 395, BR-90040371 Porto Alegre, RS, Brazil.
   [Marcadenti, Aline] Coracao Hosp IP HCor, HCor Res Inst, Abilio Soares St 250, BR-0400405 Sao Paulo, Brazil.
C3 Fundacao Universitaria de Cardiologia; Hospital do Coracao - HCor
RP Marcadenti, A (corresponding author), Univ Fdn Cardiol IC FUC, Inst Cardiol Rio Grande Sul, Grad Program Hlth Sci Cardiol, Princesa Isabel Ave 395, BR-90040371 Porto Alegre, RS, Brazil.; Marcadenti, A (corresponding author), Coracao Hosp IP HCor, HCor Res Inst, Abilio Soares St 250, BR-0400405 Sao Paulo, Brazil.
EM julia.lorenzon@gmail.com; consult.asq@gmail.com; camilawesche@gmail.com;
   silviagarofallo@hotmail.com; marcadenti.aline@gmail.com
RI de Quadros, Alexandre/AAJ-5622-2021; Marcadenti, Aline/A-8085-2012
OI Marcadenti, Aline/0000-0003-1994-4610; Weschenfelder,
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NR 82
TC 78
Z9 80
U1 5
U2 37
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD MAR
PY 2020
VL 12
IS 3
AR 682
DI 10.3390/nu12030682
PG 15
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA LL8VB
UT WOS:000531831000091
PM 32138220
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Morais, JBS
   Severo, JS
   dos Santos, LR
   Melo, SRD
   Santos, RD
   de Oliveira, ARS
   Cruz, KJC
   Marreiro, DD
AF Silva Morais, Jennifer Beatriz
   Severo, Juliana Soares
   dos Santos, Loanne Rocha
   de Sousa Melo, Stefany Rodrigues
   Santos, Raisa de Oliveira
   Soares de Oliveira, Ana Raquel
   Climaco Cruz, Kyria Jayanne
   Marreiro, Dilina do Nascimento
TI Role of Magnesium in Oxidative Stress in Individuals with Obesity
SO BIOLOGICAL TRACE ELEMENT RESEARCH
LA English
DT Article
DE Magnesium; Oxidative stress; Malondialdehyde; Superoxide dismutase;
   Glutathione peroxidase; Reactive oxygen species; Inflammation; Obesity
ID INSULIN-RESISTANCE; ADIPOSE-TISSUE; BIOCHEMICAL PARAMETERS;
   LIPID-PEROXIDATION; METABOLIC SYNDROME; INFLAMMATION; MECHANISMS;
   SUPPLEMENTATION; DEFICIENCY; DYSREGULATION
AB Adipose tissue is considered an endocrine organ that promotes excessive production of reactive oxygen species when in excess, thus contributing to lipid peroxidation. Magnesium deficiency contributes to the development of oxidative stress in obese individuals, as this mineral plays a role as an antioxidant, participates as a cofactor of several enzymes, maintains cell membrane stability and mitigates the effects of oxidative stress. The objective of this review is to bring together updated information on the participation of magnesium in the oxidative stress present in obesity. We conducted a search of articles published in the PubMed, SciELO and LILACS databases, using the keywords 'magnesium', 'oxidative stress', 'malondialdehyde', 'superoxide dismutase', 'glutathione peroxidase', 'reactive oxygen species', 'inflammation' and 'obesity'. The studies show that obese subjects have low serum concentrations of magnesium, as well as high concentrations of oxidative stress marker in these individuals. Furthermore, it is evident that the adequate intake of magnesium contributes to its appropriate homeostasis in the body. Thus, this review of current research can help define the need for intervention with supplementation of this mineral for the prevention and treatment of disorders associated with this chronic disease.
C1 [Silva Morais, Jennifer Beatriz; Severo, Juliana Soares; dos Santos, Loanne Rocha; de Sousa Melo, Stefany Rodrigues; Santos, Raisa de Oliveira; Soares de Oliveira, Ana Raquel; Climaco Cruz, Kyria Jayanne; Marreiro, Dilina do Nascimento] Univ Fed Piaui, Dept Nutr, Campus Minister Petronio Portela, BR-64048320 Teresina, Piaui, Brazil.
C3 Universidade Federal do Piaui
RP Marreiro, DD (corresponding author), Univ Fed Piaui, Dept Nutr, Campus Minister Petronio Portela, BR-64048320 Teresina, Piaui, Brazil.
EM dilina.marreiro@gmail.com
RI CRUZ, KYRIA/LOQ-9371-2024; Severo, Juliana/C-5152-2018
OI Cruz, Kyria Jayanne/0000-0002-4489-702X; Severo,
   Juliana/0000-0002-1771-7871
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NR 59
TC 92
Z9 101
U1 1
U2 26
PU HUMANA PRESS INC
PI TOTOWA
PA 999 RIVERVIEW DRIVE SUITE 208, TOTOWA, NJ 07512 USA
SN 0163-4984
EI 1559-0720
J9 BIOL TRACE ELEM RES
JI Biol. Trace Elem. Res.
PD MAR
PY 2017
VL 176
IS 1
BP 20
EP 26
DI 10.1007/s12011-016-0793-1
PG 7
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA EL2JR
UT WOS:000394446400003
PM 27444303
DA 2025-06-11
ER

PT J
AU Im, HJ
   Chu, MK
   Yang, KI
   Kim, WJ
   Hwang, I
   Yoon, JE
   Oh, D
   Thomas, RJ
   Yun, CH
AF Im, Hee-Jin
   Chu, Min Kyung
   Yang, Kwang Ik
   Kim, Won-Joo
   Hwang, Inha
   Yoon, Jee-Eun
   Oh, Dana
   Thomas, Robert J. J.
   Yun, Chang-Ho
TI The association between social jetlag and depression is independent of
   sleep debt
SO SLEEP AND BREATHING
LA English
DT Article
DE Sleep-corrected social jetlag; Depression; Sleep debt; Weekend sleep
   extension
ID CATCH-UP SLEEP; METABOLIC SYNDROME; DURATION; CHRONOTYPE; HYPERTENSION;
   ENDOCRINE; MORTALITY; LIFE; LAG
AB ObjectivesTo investigate whether the association between SJLsc (sleep-corrected social jetlag) and depressive mood is significant and independent of sleep debt.MethodsParticipants from the general adult population were interviewed using structured questionnaires on sleep duration, weekday/weekend sleep schedules, and depressive mood (Patient Health Questionnaire-9). Social jetlag (SJL) was measured by SJLsc and standard SJL (SJLs). SJLs was the absolute difference between mid-sleep time on free days (MSF) and workdays (MSW). For SJLsc, both MSF and MSW were adjusted for average sleep duration across the week according to the direction of sleep debt. Sleep debt was defined by sleep extension on free days. The association of SJL with depression was investigated, and covariates included age, sex, sociodemographic factors, insomnia symptoms, sleep duration, and sleep debt.ResultsA total of 1982 individuals (1089 men; age 43.1 +/- 14.4 years) were analyzed. SJL was present in 24.6% measured by SJLsc and 51.0% by SJLs. SJLsc and SJLs were significantly associated with depressive mood (r = 0.06, P = 0.02; r = 0.06, P = 0.01, respectively), independent of sleep debt. Sleep debt was also associated with depression (r = 0.07, P < 0.01).ConclusionsBy adopting sleep-corrected formula for SJL, this study found that misaligned and insufficient sleep, at levels occurring in routine social life, can negatively affect mood. Minimizing social jetlag and sleep deprivation may promote individual psychological well-being.
C1 [Im, Hee-Jin] Hallym Univ, Dongtan Sacred Heart Hosp, Dept Neurol, Coll Med, Hwaseong, South Korea.
   [Chu, Min Kyung] Yonsei Univ, Severance Hosp, Coll Med, Dept Neurol, Seoul, South Korea.
   [Yang, Kwang Ik] Soonchunhyang Univ, Cheonan Hosp, Sleep Disorders Ctr, Dept Neurol,Coll Med, Cheonan, South Korea.
   [Kim, Won-Joo] Yonsei Univ, Gangnam Severance Hosp, Coll Med, Dept Neurol, Seoul, South Korea.
   [Hwang, Inha; Yun, Chang-Ho] Seoul Natl Univ, Seoul Natl Univ Bundang Hosp, Dept Neurol, 82 Gumi Ro,173 Beon Gil, Seongnam 13620, Gyeonggi, South Korea.
   [Hwang, Inha; Yun, Chang-Ho] Seoul Natl Univ, Coll Med, 82 Gumi Ro,173 Beon Gil, Seongnam 13620, Gyeonggi, South Korea.
   [Yoon, Jee-Eun] Bucheon Soonchunhyang Univ Hosp, Dept Neurol, Bucheon, South Korea.
   [Oh, Dana] Seoul Med Ctr, Dept Neurol, Seoul, South Korea.
   [Thomas, Robert J. J.] Beth Israel Deaconess Med Ctr, Dept Med, Div Pulm Crit Care & Sleep Med, Boston, MA USA.
C3 Hallym University; Yonsei University; Yonsei University Health System;
   Soonchunhyang University; Yonsei University; Yonsei University Health
   System; Seoul National University (SNU); Seoul National University
   Hospital; Seoul National University (SNU); Soonchunhyang University;
   Seoul Medical Center; Harvard University; Harvard University Medical
   Affiliates; Beth Israel Deaconess Medical Center
RP Yun, CH (corresponding author), Seoul Natl Univ, Seoul Natl Univ Bundang Hosp, Dept Neurol, 82 Gumi Ro,173 Beon Gil, Seongnam 13620, Gyeonggi, South Korea.; Yun, CH (corresponding author), Seoul Natl Univ, Coll Med, 82 Gumi Ro,173 Beon Gil, Seongnam 13620, Gyeonggi, South Korea.
EM ych333@gmail.com
OI Chu, Min Kyung/0000-0001-6221-1346; Kim, Won-Joo/0000-0002-5850-010X;
   Yun, Chang-Ho/0000-0003-2204-8067
FU Korean Neurological Association, Republic of Korea [KNA-10-MI-03]
FX This study was supported by grants from the Korean Neurological
   Association (KNA-10-MI-03), Republic of Korea
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NR 35
TC 6
Z9 6
U1 3
U2 10
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1520-9512
EI 1522-1709
J9 SLEEP BREATH
JI Sleep Breath.
PD DEC
PY 2023
VL 27
IS 6
BP 2459
EP 2467
DI 10.1007/s11325-023-02849-6
EA MAY 2023
PG 9
WC Clinical Neurology; Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Respiratory System
GA Y4XX8
UT WOS:000987925000001
PM 37184756
DA 2025-06-11
ER

PT J
AU Akter, T
   Zahan, MS
   Nawal, N
   Rahman, MH
   Tanjum, TN
   Arafat, KI
   Moni, A
   Islam, MN
   Uddin, MJ
AF Akter, Tanzina
   Zahan, Md. Sarwar
   Nawal, Nafisa
   Rahman, Md. Hasanur
   Tanjum, Tayyabatun Nur
   Arafat, Kazi Ifthi
   Moni, Akhi
   Islam, Mohammad Nazrul
   Uddin, Md Jamal
TI Potentials of curcumin against polycystic ovary syndrome:
   Pharmacological insights and therapeutic promises
SO HELIYON
LA English
DT Review
DE PCOS; Hyperandrogenism; Oxidative stress; Insulin resistance;
   Inflammation; Hyperglycemia; Hyperlipidemia; Apoptosis
ID C-REACTIVE PROTEIN; CHRONIC KIDNEY-DISEASE; NECROSIS-FACTOR-ALPHA;
   KAPPA-B ACTIVATION; INSULIN-RESISTANCE; OXIDATIVE STRESS; SYNDROME PCOS;
   DOUBLE-BLIND; ANTHROPOMETRIC INDEXES; METABOLIC SYNDROME
AB Polycystic ovary syndrome (PCOS) is a common hormonal disorder among women (4%-20%) when the ovaries create abnormally high levels of androgens, the male sex hormones that are typically present in women in trace amounts. The primary characteristics of PCOS include oxidative stress, inflammation, hyperglycemia, hyperlipidemia, hyperandrogenism, and insulin resistance. Generally, metformin, spironolactone, eflornithine and oral contraceptives are used to treat PCOS, despite their several side effects. Therefore, finding a potential candidate for treating PCOS is necessary. Curcumin is a major active natural polyphenolic compound derived from turmeric (Curcuma longa). A substantial number of studies have shown that curcumin has antiinflammatory, anti-oxidative stress, antibacterial, and anti-apoptotic activities. In addition, curcumin reduces hyperglycemia, hyperlipidemia, hyperandrogenism, and insulin resistance in various conditions, including PCOS. The review highlighted the therapeutic aspects of curcumin against the pathophysiology of PCOS. We also offer a hypothesis to improve the development of medicines based on curcumin against PCOS.
C1 [Akter, Tanzina; Zahan, Md. Sarwar; Nawal, Nafisa; Rahman, Md. Hasanur; Tanjum, Tayyabatun Nur; Arafat, Kazi Ifthi; Moni, Akhi; Islam, Mohammad Nazrul; Uddin, Md Jamal] ABEx Biores Ctr, Dhaka 1230, Bangladesh.
   [Islam, Mohammad Nazrul] Sher E Bangla Agr Univ, Dept Biotechnol, Dhaka 1207, Bangladesh.
C3 Sher-e-Bangla Agricultural University (SAU)
RP Uddin, MJ (corresponding author), ABEx Biores Ctr, Dhaka 1230, Bangladesh.
EM hasan800920@gmail.com
RI Akter, Tanzina/ABG-6726-2021; Rahman, Hasanur/AAX-4023-2020; Zahan, Md.
   Sarwar/AFS-4089-2022; Uddin, Md Jamal/W-3434-2017; Islam, Mohammad
   Nazrul/JAN-7145-2023
OI Islam, Mohammad Nazrul/0000-0001-5692-3566; Arafat, Kazi
   Ifthi/0000-0002-0488-1429; Rahman, MD. Hasanur/0000-0001-9238-3149;
   Uddin, Md Jamal/0000-0003-2911-3255
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NR 135
TC 11
Z9 12
U1 4
U2 17
PU CELL PRESS
PI CAMBRIDGE
PA 50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA
EI 2405-8440
J9 HELIYON
JI Heliyon
PD JUN
PY 2023
VL 9
IS 6
AR e16957
DI 10.1016/j.heliyon.2023.e16957
EA JUN 2023
PG 16
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA O1FJ1
UT WOS:001041343000001
PM 37346347
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Ruiz, GP
   Camara, H
   Fazolini, NPB
   Mori, MA
AF Ruiz, Gabriel Palermo
   Camara, Henrique
   Fazolini, Narayana P. B.
   Mori, Marcelo A.
TI Extracellular miRNAs in redox signaling: Health, disease and potential
   therapies
SO FREE RADICAL BIOLOGY AND MEDICINE
LA English
DT Article
DE Oxidative stress; Redox biology; miRNA; Extracellular vesicles;
   Exosomes; Cancer; Cardiovascular disease; Metabolic syndrome;
   Neurodegenerative diseases; Aging; RNA therapeutics
ID SMOOTH-MUSCLE-CELLS; INSULIN-RESISTANCE; OXIDATIVE STRESS;
   ADIPOSE-TISSUE; BETA-CELL; CIRCULATING MICROPARTICLES; CARDIOMYOCYTE
   APOPTOSIS; MACROPHAGE ACTIVATION; MICRORNA BIOGENESIS; ENDOTHELIAL-CELLS
AB Extracellular microRNAs (miRNAs) have emerged as important mediators of cell-to-cell communication and intertissue crosstalk. MiRNAs are produced by virtually all types of eukaryotic cells and can be selectively packaged and released to the extracellular medium, where they may reach distal cells to regulate gene expression cell non-autonomously. By doing so, miRNAs participate in integrative physiology. Oxidative stress affects miRNA expression, while miRNAs control redox signaling. Disruption in miRNA expression, processing or release to the extracellular compartment are associated with aging and a number of chronic diseases, such as obesity, type 2 diabetes, neurodegenerative diseases and cancer, all of them being conditions related to oxidative stress. Here we discuss the interplay between redox balance and miRNA function and secretion as a determinant of health and disease states, reviewing the findings that support this notion and highlighting novel and yet understudied venues of research in the field.
C1 [Ruiz, Gabriel Palermo; Camara, Henrique; Fazolini, Narayana P. B.; Mori, Marcelo A.] Univ Estadual Campinas, Inst Biol, Dept Biochem & Tissue Biol, Campinas, SP, Brazil.
   [Mori, Marcelo A.] Univ Estadual Campinas, Expt Med Res Cluster EMRC, Campinas, SP, Brazil.
   [Mori, Marcelo A.] Univ Estadual Campinas, Obes & Comorbid Res Ctr OCRC, Campinas, SP, Brazil.
C3 Universidade Estadual de Campinas; Universidade de Sao Paulo;
   Universidade Estadual de Campinas; Universidade Estadual de Campinas
RP Mori, MA (corresponding author), Univ Estadual Campinas, Inst Biol, Dept Biochem & Tissue Biol, Campinas, SP, Brazil.
EM morima@unicamp.br
RI Camara, Henrique/KDO-6799-2024; Mori, Marcelo/R-2881-2018
OI Camara, Henrique/0000-0001-7300-1416; Palermo Ruiz,
   Gabriel/0000-0002-5660-1396
FU Fundacao de Amparo a` Pesquisa do Estado de Sao Paulo [2017/01339-2,
   2018/21635-8, 2017/01184-9, 2017/07975-8, 2017/23920-9]; Fundacao de
   Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [17/23920-9,
   17/01339-2, 18/21635-8, 17/01184-9] Funding Source: FAPESP
FX We acknowledge Fabio Hecht for the illustrations and artwork. Au-thors
   were supported by grants of Fundacao de Amparo a` Pesquisa do Estado de
   Sao Paulo (2017/01339-2 to H.C.; 2018/21635-8 to G.P.R.; and
   2017/01184-9, 2017/07975-8, and 2017/23920-9 to M.A.M) .
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NR 255
TC 19
Z9 20
U1 0
U2 6
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0891-5849
EI 1873-4596
J9 FREE RADICAL BIO MED
JI Free Radic. Biol. Med.
PD SEP
PY 2021
VL 173
BP 170
EP 187
DI 10.1016/j.freeradbiomed.2021.05.004
EA JUL 2021
PG 18
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA UJ8NA
UT WOS:000691534600002
PM 33965563
DA 2025-06-11
ER

PT J
AU Yubero-Serrano, EM
   Lopez-Moreno, J
   Gomez-Delgado, F
   Lopez-Miranda, J
AF Yubero-Serrano, Elena M.
   Lopez-Moreno, Javier
   Gomez-Delgado, Francisco
   Lopez-Miranda, Jose
TI Extra virgin olive oil: More than a healthy fat
SO EUROPEAN JOURNAL OF CLINICAL NUTRITION
LA English
DT Article; Proceedings Paper
CT 11th International Mediterranean Diet Conference on Mediterranean Diet
   as a Lifestyle and Dynamic Food Pattern
CY APR, 2016
CL Barcelona, SPAIN
ID CARDIOVASCULAR RISK-FACTORS; POSTPRANDIAL ENDOTHELIAL FUNCTION;
   MEDITERRANEAN-STYLE DIET; LOW-DENSITY-LIPOPROTEIN;
   CORONARY-HEART-DISEASE; METABOLIC SYNDROME; PHENOLIC-COMPOUNDS;
   OXIDATIVE STRESS; ELDERLY-MEN; FACTOR-VII
AB The beneficial effects of a Mediterranean diet on human health and, in particular, on lowering risk of cardiovascular disease, has been mainly attributed to its high content to extra virgin olive oil (EVOO). While its main fatty acid, oleic acid, is considered important to these effects, EVOO has other biological properties that depend on, or are potentiated by other minor components of this oil. Initially, the mechanisms considered as possible causes of this cardioprotective effect of EVOO were based on the incidence on the so-called traditional risk factors (especially lipids and blood pressure). However, the high relative reduction in the prevalence of cardiovascular morbidity and mortality were not proportional to the limited findings about regulation of those traditional risk factors. In addition to several studies confirming the above effects, current research on beneficial effect of EVOO, and in particular in conjunction with Mediterranean style diets, is being focused on defining its effects on newer cardiovascular risk factors, such as inflammation, oxidative stress, coagulation, platelet aggregation, fibrinolysis, endothelial function or lipids or on the modulation of the conditions which predispose people to cardiovascular events, such as obesity, metabolic syndrome or type 2 diabetes mellitus. In the current review, we will mainly focus on reviewing the current evidence about the effects that EVOO exerts on alternative factors, including postprandial lipemia or coagulation, among others, discussing the underlying mechanism by which it exerts its effect, as well as providing a short review on future directions.
C1 [Yubero-Serrano, Elena M.; Lopez-Moreno, Javier; Gomez-Delgado, Francisco; Lopez-Miranda, Jose] Univ Cordoba, Reina Sofia Univ Hosp, Maimonides Biomed Res Inst Cordoba IMIBIC, Lipids & Atherosclerosis Unit, Cordoba, Spain.
   [Yubero-Serrano, Elena M.; Lopez-Moreno, Javier; Gomez-Delgado, Francisco; Lopez-Miranda, Jose] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr CIBEROBN, Madrid, Spain.
C3 Universidad de Cordoba; Instituto de Salud Carlos III; CIBER - Centro de
   Investigacion Biomedica en Red; CIBEROBN
RP Lopez-Miranda, J (corresponding author), Univ Cordoba, Reina Sofia Univ Hosp, Maimonides Biomed Res Inst Cordoba IMIBIC, Lipids & Atherosclerosis Unit, Cordoba, Spain.; Lopez-Miranda, J (corresponding author), Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr CIBEROBN, Madrid, Spain.
EM jlopezmir@uco.es
RI YUBERO, ELENA/AFM-2738-2022; Lopez-Miranda, Jose/Y-8306-2019; Gomez
   Delgado, Francisco/H-4552-2015
OI Lopez-Miranda, Jose/0000-0002-8844-0718; Yubero-Serrano, Elena
   M/0000-0002-2733-5359; Gomez Delgado, Francisco/0000-0002-0216-2084
FU Ministry of Science and Innovation [AGL2004-07907, AGL2006-01979,
   AGL2009-12270]; Ministry of Science and Competitiveness [AGL2012-39615,
   AGL2015-67896-P]; Carlos III Health Institute (FIS) [PIE14/00031,
   PIE14/00005]; Ministry of Economy, Innovation, Science and Employment
   [CVI-7450]; Mediterranean Diet Foundation; Diputacio de Barcelona
FX Supported in part by research grants from the Ministry of Science and
   Innovation (AGL2004-07907, AGL2006-01979, AGL2009-12270), Ministry of
   Science and Competitiveness (AGL2012-39615, AGL2015-67896-P), Training
   in health research Proyects by Carlos III Health Institute (FIS)
   (PIE14/00031 and PIE14/00005), Ministry of Economy, Innovation, Science
   and Employment (CVI-7450). This article is published as part of a
   supplement sponsored by the Mediterranean Diet Foundation and the
   Diputacio de Barcelona.
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NR 106
TC 153
Z9 160
U1 1
U2 39
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0954-3007
EI 1476-5640
J9 EUR J CLIN NUTR
JI Eur. J. Clin. Nutr.
PY 2019
VL 72
SU S
BP 8
EP 17
DI 10.1038/s41430-018-0304-x
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Nutrition & Dietetics
GA JC2ML
UT WOS:000489111000013
PM 30487558
DA 2025-06-11
ER

PT J
AU Cordero, MD
   Cotán, D
   del-Pozo-Martín, Y
   Carrión, AM
   de Miguel, M
   Bullón, P
   Sánchez-Alcazar, JA
AF Cordero, Mario D.
   Cotan, David
   del-Pozo-Martin, Yaiza
   Carrion, Angel M.
   de Miguel, Manuel
   Bullon, Pedro
   Antonio Sanchez-Alcazar, Jose
TI Oral coenzyme Q10 supplementation improves clinical symptoms and
   recovers pathologic alterations in blood mononuclear cells in a
   fibromyalgia patient
SO NUTRITION
LA English
DT Article
DE Fibromyalgia; Coenzyme Q; Mitochondrial biogenesis; Oxidative stress
ID MITOCHONDRIAL DYSFUNCTION; METABOLIC SYNDROME; COPY NUMBER; DNA
AB Fibromyalgia (FM) is a chronic pain syndrome with unknown etiology. Recent studies have shown evidence demonstrating that mitochondrial dysfunction and oxidative stress may have a role in the pathophysiology of FM. Coenzyme Q10 (CoQ10) is an essential electron carrier in the mitochondrial respiratory chain and a strong antioxidant. Low CoQ10 levels have been detected in patients with FM, and a significant decrease of clinical symptoms has been reported after oral CoQ10 supplementation. In this report, we show the effect of CoQ10 treatment on clinical symptoms, blood mononuclear cells, and mitochondrial and oxidative stress markers from a woman with FM. After CoQ10 treatment, the patient reported a significant improvement of clinical symptoms. At the cellular level, CoQ10 treatment restored mitochondrial dysfunction and the mtDNA copy number, decreased oxidative stress, and increased mitochondrial biogenesis. Our results suggest that CoQ10 could be an alternative therapeutic approach for FM. Crown Copyright (C) 2012 Published by Elsevier Inc. All rights reserved.
C1 [Cordero, Mario D.; Cotan, David; Antonio Sanchez-Alcazar, Jose] Univ Pablo Olavide, CSIC Junta Andalucia, Ctr Andaluz Biol Desarrollo, Seville, Spain.
   [Cordero, Mario D.; Cotan, David; Antonio Sanchez-Alcazar, Jose] ISCIII, Ctr Invest Biomed Red Enfermedades Raras, Seville, Spain.
   [Cordero, Mario D.; de Miguel, Manuel] Univ Seville, Fac Med, Dept Citol & Histol Normal & Patol, Seville, Spain.
   [del-Pozo-Martin, Yaiza; Carrion, Angel M.] Univ Pablo Olavide Sevilla, Div Neurociencias, Seville, Spain.
   [Bullon, Pedro] Univ Seville, Fac Odontol, Dpto Periodontl, Seville, Spain.
C3 Consejo Superior de Investigaciones Cientificas (CSIC); Universidad
   Pablo de Olavide; CSIC - Andalusian Center for Developmental Biology
   (CABD); Instituto de Salud Carlos III; CIBER - Centro de Investigacion
   Biomedica en Red; CIBERER; University of Sevilla; Universidad Pablo de
   Olavide; University of Sevilla
RP Cordero, MD (corresponding author), Univ Pablo Olavide, CSIC Junta Andalucia, Ctr Andaluz Biol Desarrollo, Seville, Spain.
EM mdcormor@upo.es
RI De-Miguel, Manuel/B-3713-2017; Bullon, Pedro/E-6319-2010; Cordero, Mario
   D./L-8006-2014; Carrion Rodriguez, Angel Manuel/K-5875-2014;
   Sanchez-Alcazar, Jose A./L-4925-2014
OI De-Miguel, Manuel/0000-0002-6751-1695; Bullon,
   Pedro/0000-0003-4873-4196; Cordero, Mario D./0000-0003-0151-3644; del
   Pozo Martin, Yaiza/0000-0002-8053-6256; Carrion Rodriguez, Angel
   Manuel/0000-0001-8158-9512; Sanchez-Alcazar, Jose A./0000-0001-9705-1469
FU Servicio Andaluz de Salud [FIS PI10/00543, FIS EC08/00076, SAS 111242];
   Asociacion de Enfermos de Patologia Mitocondrial; Federacion Andaluza de
   Fibromialgia y Fatiga Cronica (ALBA Andalucia)
FX This group was founded by the Centro de Investigacion Biomedica en Red
   de Enfermedades Raras, ISCIII. This work was supported by grants FIS
   PI10/00543, FIS EC08/00076, and SAS 111242 from the Servicio Andaluz de
   Salud, the Asociacion de Enfermos de Patologia Mitocondrial, and the
   Federacion Andaluza de Fibromialgia y Fatiga Cronica (ALBA Andalucia).
CR Adhihetty PJ, 2007, AM J PHYSIOL-ENDOC M, V293, pE672, DOI 10.1152/ajpendo.00043.2007
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NR 17
TC 40
Z9 42
U1 0
U2 18
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0899-9007
J9 NUTRITION
JI Nutrition
PD NOV-DEC
PY 2012
VL 28
IS 11-12
BP 1200
EP 1203
DI 10.1016/j.nut.2012.03.018
PG 4
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 028BI
UT WOS:000310397400024
PM 22898267
DA 2025-06-11
ER

PT J
AU Cardona, F
   Túnez, I
   Tasset, I
   Garrido-Sánchez, L
   Collantes, E
   Tinahones, FJ
AF Cardona, Fernando
   Tunez, Isaac
   Tasset, Inmaculada
   Garrido-Sanchez, Lourdes
   Collantes, Eduardo
   Tinahones, Francisco Jose
TI Circulating antioxidant defences are decreased in healthy people after a
   high-fat meal
SO BRITISH JOURNAL OF NUTRITION
LA English
DT Article
DE uric acid; oxidative stress; postprandial hyperlipidaemia; high-fat meal
ID URIC-ACID; OXIDATIVE STRESS; RENAL EXCRETION; ENDOTHELIAL FUNCTION;
   PLASMA; CAPACITY; DISEASE; URATE; RISK
AB The aim of this study was to examine the responses of uric acid, antioxidant defences and pro-oxidant variables after a high-fat meal. Twenty-five healthy persons without criteria for the metabolic syndrome, underwent a high-fat meal with Supracal (R) (60 g fat). Measurements were made at baseline and 3 h after the meal of TAG, uric acid, HDL-cholesterol, total proteins and oxidative stress. Following the high-fat meal, we detected a significant increase in pro-oxidative variables and a decrease in antioxidative variables. The uric acid concentrations were significantly lower after the high-fat meal and the reduction correlated significantly with the oxidative stress variables. The inverse relation between reduced uric acid and increased carbonylated proteins remained in multiple regression analysis. We conclude that uric acid is a powerful antioxidant and its reduction following a high-fat meal may be related with its acute antioxidative action.
C1 [Cardona, Fernando; Garrido-Sanchez, Lourdes; Tinahones, Francisco Jose] Univ Virgen Victoria, Hosp Clin, Serv Endocrinol & Nutr, Malaga 29009, Spain.
   [Cardona, Fernando; Garrido-Sanchez, Lourdes; Tinahones, Francisco Jose] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr CB06 03, Malaga 29009, Spain.
   [Tunez, Isaac; Tasset, Inmaculada] Univ Cordoba, Fac Med, Dept Bioquim & Biol Mol, E-14071 Cordoba, Spain.
   [Collantes, Eduardo] Univ Cordoba, Serv Reumatol, Hosp Univ Reina Sofia Cordoba, E-14004 Cordoba, Spain.
   [Collantes, Eduardo] Univ Cordoba, Dept Med, E-14004 Cordoba, Spain.
C3 Instituto de Salud Carlos III; CIBER - Centro de Investigacion Biomedica
   en Red; CIBEROBN; Universidad de Cordoba; Hospital Universitario Reina
   Sofia - Cordoba; Universidad de Cordoba; Universidad de Cordoba
RP Tinahones, FJ (corresponding author), Univ Virgen Victoria, Hosp Clin, Serv Endocrinol & Nutr, Malaga 29009, Spain.
EM fjtinahones@terra.es
RI Tinahones, Francisco/AAB-2882-2020; Cardona, Fernando/AAG-7835-2019;
   Cuevas, Inmaculada/R-4509-2019; Collantes-Estevez, Eduardo/M-9549-2019;
   Cardona, Fernando/H-6022-2015
OI Collantes Estevez, Eduardo/0000-0002-7647-6289; Tinahones, Francisco
   J/0000-0001-6871-4403; Cardona, Fernando/0000-0003-4460-6824
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NR 38
TC 21
Z9 22
U1 0
U2 3
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1145
EI 1475-2662
J9 BRIT J NUTR
JI Br. J. Nutr.
PD AUG
PY 2008
VL 100
IS 2
BP 312
EP 316
DI 10.1017/S0007114507894347
PG 5
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 330OF
UT WOS:000257952000012
PM 18184452
OA Bronze
DA 2025-06-11
ER

PT J
AU Lee, H
   Im, SW
   Jung, CH
   Jang, YJ
   Ha, TY
   Ahn, J
AF Lee, Hyunjung
   Im, Sung Won
   Jung, Chang Hwa
   Jang, Young Jin
   Ha, Tae Youl
   Ahn, Jiyun
TI Tyrosol, an olive oil polyphenol, inhibits ER stress-induced apoptosis
   in pancreatic β-cell through JNK signaling
SO BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
LA English
DT Article
DE Tyrosol; ER stress; beta-Cell failure; Apoptosis; NIT-1
ID ENDOPLASMIC-RETICULUM STRESS; ACTIVATION; FAILURE; LINE; PERK
AB Dysfunction of pancreatic beta-cell is a major determinant for the development of type 2 diabetes. Because of the stimulated insulin secretion in metabolic syndrome, endoplasmic reticulum (ER) stress plays a central mediator for beta-cell failure. In this study, we investigated whether an antioxidant phenolic compound, tyrosol protects against beta-cell dysfunction associated with ER stress. To address this issue, we exposed pancreatic beta cells, NIT-1 to tunicamycin with tyrosol. We found tyrosol diminished tunicamycin-induced cell death in a dose-dependent manner. We also detected tyrosol decreased the expressions of apoptosis-related markers. Exposure to tunicamycin evoked UPR response and co-treatment of tyrosol led to reduction of ER stress. These effects of tyrosol were mediated by the phosphorylation of JNK. Moreover, we confirmed supplement of tyrosol ameliorated beta-cell loss induced by high fat feeding. Taken together, our study provides a molecular basis for signaling transduction of protective effect of tyrosol against ER stress-induced beta-cell death. Therefore, we suggest tyrosol could be a potential therapeutic candidate for amelioration of type 2 diabetes. (C) 2015 Elsevier Inc. All rights reserved.
C1 [Lee, Hyunjung; Im, Sung Won; Jung, Chang Hwa; Jang, Young Jin; Ha, Tae Youl; Ahn, Jiyun] Korea Food Res Inst, Res Grp Metab Mech, 1201-62 Anyangpangyo Ro, Songnam 13539, Gyeonggi, South Korea.
   [Jung, Chang Hwa; Ha, Tae Youl; Ahn, Jiyun] Univ Sci & Technol, Div Food Biotechnol, Daejeon 34113, South Korea.
C3 Korea Food Research Institute (KFRI); University of Science & Technology
   (UST)
RP Ahn, J (corresponding author), Korea Food Res Inst, Res Grp Metab Mech, 1201-62 Anyangpangyo Ro, Songnam 13539, Gyeonggi, South Korea.
EM jyan@kfri.re.kr
RI Jang, Young/AAT-1192-2020
OI Jang, Young Jin/0000-0003-0553-2498
FU Korea Food Research Institute [E0143033654]
FX This work was supported by Korea Food Research Institute (#E0143033654).
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NR 31
TC 28
Z9 32
U1 1
U2 26
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0006-291X
EI 1090-2104
J9 BIOCHEM BIOPH RES CO
JI Biochem. Biophys. Res. Commun.
PD JAN 15
PY 2016
VL 469
IS 3
BP 748
EP 752
DI 10.1016/j.bbrc.2015.12.036
PG 5
WC Biochemistry & Molecular Biology; Biophysics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics
GA DC6TP
UT WOS:000369352800065
PM 26692476
DA 2025-06-11
ER

PT J
AU Iijima, K
   Iimuro, S
   Ohashi, Y
   Sakurai, T
   Umegaki, H
   Araki, A
   Yoshimura, Y
   Ouchi, Y
   Ito, H
AF Iijima, Katsuya
   Iimuro, Satoshi
   Ohashi, Yasuo
   Sakurai, Takashi
   Umegaki, Hiroyuki
   Araki, Atsushi
   Yoshimura, Yukio
   Ouchi, Yasuyoshi
   Ito, Hideki
CA Japanese Elderly Diabet Interventi
TI Lower physical activity, but not excessive calorie intake, is associated
   with metabolic syndrome in elderly with type 2 diabetes mellitus: The
   Japanese elderly diabetes intervention trial
SO GERIATRICS & GERONTOLOGY INTERNATIONAL
LA English
DT Article
DE depression; elderly; excessive calorie intake; Japanese Elderly Diabetes
   Intervention Trial study; metabolic syndrome; physical activity; work
   activity
ID CORONARY-HEART-DISEASE; RANDOMIZED CONTROLLED-TRIAL; DEPRESSIVE
   SYMPTOMS; GENERAL-PRACTICE; RISK; PEOPLE; FEDERATION; MORTALITY
AB Aim: A decline in physical activity has been shown to be associated with metabolic syndrome (MetS), leading to cardiovascular events. However, this is difficult to manage well in the elderly with multiple atherosclerotic risk factors. In this study, we investigated the correlation between physical activity and clinical parameters in the presence and absence of MetS in Japanese elderly subjects with type 2 diabetes mellitus (T2DM). In addition, we determined which factor, calorie intake or physical activity, mainly contributes to the prevalence of MetS.
   Methods: Cross- sectional analysis of 846 consecutive Japanese elderly (408 men and 438 women, mean age 68.7 years) was carried out at the time of enrolment (2000-2002) in the Japanese Elderly Diabetes Intervention Trial. Their level of physical activity was evaluated using the Baecke questionnaire, consisting of three components: work, sports and leisure. Total activity score (TAS) as the sum of each activity score was divided into four quartiles (Q1 to Q4).
   Results: After adjustment for age and sex, there was a positive association of TAS with high-density lipoprotein cholesterol, although no significant correlation between other lipid parameters and TAS was found. In addition, fasting plasma glucose, insulin level and physical measurements, such as waist circumference, waist/hip ratio and body mass index, were inversely associated with TAS. Although no correlation between TAS and cognitive function Mini- Mental State Examination was found, TAS was positively associated with instrumental ADL and negatively associated with geriatric depression score (GDS), suggesting that a decline in physical activity in the elderly is associated with depressed mood rather than a decline of cognitive function. Total calorie intake appeared to increase according to TAS; however, this did not reach statistical significance. In a subanalysis comparing the presence and absence of MetS, the TAS grade in the MetS group was significantly lower than that in the non- MetS group, although there was no significant difference in total calorie intake between the groups.
   Conclusion: These results showed that lower physical activity, but not excessive calorie intake, is independently associated with the prevalence of MetS in the elderly with T2DM. In our routine work, encouraging physical activity might contribute to preventing MetS and subsequent atherosclerotic disease in the elderly, rather than strict management of abnormal laboratory parameters using multiple drugs. Geriatr Gerontol Int 2012; 12 (Suppl. 1): 68-76.
C1 [Iijima, Katsuya] Univ Tokyo, Dept Geriatr Med, Grad Sch Med, Bunkyo Ku, Tokyo 1138655, Japan.
   [Iijima, Katsuya] Univ Tokyo, Inst Gerontol, Tokyo 1138655, Japan.
   [Iimuro, Satoshi; Ohashi, Yasuo] Univ Tokyo, Grad Sch Med, Sch Publ Hlth, Dept Biostat, Tokyo 1138655, Japan.
   [Sakurai, Takashi] Natl Ctr Geriatr & Gerontol, Ctr Comprehens Care & Res Demented Disorders, Oobu, Aichi, Japan.
   [Sakurai, Takashi] Kobe Univ, Grad Sch Med, Dept Geriatr Med, Kobe, Hyogo 657, Japan.
   [Umegaki, Hiroyuki] Nagoya Univ, Grad Sch Med, Dept Community Healthcare & Geriatr, Nagoya, Aichi 4648601, Japan.
   [Araki, Atsushi; Ito, Hideki] Tokyo Metropolitan Geriatr Hosp, Dept Diabet Metab & Endocrinol, Tokyo 173, Japan.
   [Yoshimura, Yukio] Shikoku Univ, Fac Human Life Sci, Training Dept Adm Dietitians, Tokushima, Japan.
C3 University of Tokyo; University of Tokyo; University of Tokyo; National
   Center for Geriatrics & Gerontology; Kobe University; Nagoya University;
   Tokyo Metropolitan Institute of Gerontology
RP Iijima, K (corresponding author), Univ Tokyo, Dept Geriatr Med, Grad Sch Med, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1138655, Japan.
EM katsu-tky@umin.ac.jp
RI Araki, Atsushi/JVE-0081-2024
OI Araki, Atsushi/0000-0001-9088-2841
FU Ministry of Health and Labour, and Welfare [H12-Choju-016,
   H15-Chojyu-016, H17-Choju-Ordinal-013]; Japan Foundation for Aging and
   Health
FX The registration number for this clinical trial was UMIN000000890. This
   study was financially supported by Research Grants for Longevity
   Sciences from the Ministry of Health and Labour, and Welfare
   (H12-Choju-016, H15-Chojyu-016, H17-Choju-Ordinal-013) and the Japan
   Foundation for Aging and Health.
CR Akisaki T, 2006, DIABETES-METAB RES, V22, P376, DOI 10.1002/dmrr.632
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NR 30
TC 16
Z9 19
U1 1
U2 26
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1444-1586
EI 1447-0594
J9 GERIATR GERONTOL INT
JI Geriatr. Gerontol. Int.
PD APR
PY 2012
VL 12
SU 1
SI SI
BP 68
EP 76
DI 10.1111/j.1447-0594.2011.00814.x
PG 9
WC Geriatrics & Gerontology; Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA 912DW
UT WOS:000301775900008
PM 22435942
DA 2025-06-11
ER

PT J
AU Park, CG
   Lee, SH
   Chu, MK
AF Park, Chae Gyu
   Lee, Sue Hyun
   Chu, Min Kyung
TI No change in interictal C-reactive protein levels in individuals with
   episodic and chronic migraine: A case-control study and literature
   review
SO FRONTIERS IN NEUROLOGY
LA English
DT Review
DE biomarker; C-reactive protein; inflammation; migraine; headache
ID MAJOR DEPRESSIVE DISORDER; ACUTE-PHASE PROTEINS; CARDIOVASCULAR-DISEASE;
   ENDOTHELIAL FUNCTION; INSULIN-RESISTANCE; METABOLIC SYNDROME; PROBABLE
   MIGRAINE; SEX-DIFFERENCES; SERUM-LEVELS; BIOMARKERS
AB ObjectivesThe levels of some migraine biomarkers differ between episodic migraine (EM) and chronic migraine (CM), but information on C-reactive protein (CRP) levels in EM and CM is conflicting. Thus, this study aimed to evaluate CRP levels in participants with EM and CM in comparison to those in healthy controls. MethodsPlasma CRP levels were evaluated by high-sensitivity CRP tests in female participants with EM (n = 174) and CM (n = 191) and healthy controls (n = 50). ResultsThe results showed no significant difference in CRP levels among the EM, CM, and control groups (median and interquartile range, 0.40 [0.15-0.70] mg/L vs. 0.40 [0.15-1.00] mg/L vs. 0.15 [0.15-0.90] mg/L, p = 0.991). The ratio of individuals with elevated CRP levels (>3.0 mg/L) did not significantly differ among the EM, CM, and control groups (3.4% [6/174] vs. 2.1% [4/191] vs. 0.0% [0/50], p = 0.876). Multivariable regression analyses revealed that CRP levels were not significantly associated with headache frequency per month (beta = -0.076, p = 0.238), the severity of anxiety (Generalized Anxiety Disorder-7 score, beta = 0.143, p = 0.886), and depression (Patient Health Questionnaire-9 score, beta = 0.143, p = 0.886). Further, CRP levels did not significantly differ according to clinical characteristics, fibromyalgia, medication overuse, preventive treatment, and classes of preventive treatment medications. Among participants with a body mass index >= 25 kg/m(2), the CRP levels in EM (n = 41) and CM (n = 17) were numerically higher than those in the control (n = 6) (1.30 [0.28-4.25] mg/L vs. 1.10 [0.50-3.15] mg/L vs. 0.40 [0.15-0.83] mg/L, p = 0.249) but did not reach statistical significance. ConclusionsThe interictal CRP level is not likely to be a biomarker for EM or CM.
C1 [Park, Chae Gyu] Ewha Womans Univ, Heart Immune Brain Network Res Ctr, Dept Life Sci, Seoul, South Korea.
   [Park, Chae Gyu] Yonsei Univ, Severance Biomed Sci Inst, Lab Immunol, Coll Med, Seoul, South Korea.
   [Park, Chae Gyu] Genuv Inc, Therapeut Antibody Res Ctr, Seoul, South Korea.
   [Lee, Sue Hyun; Chu, Min Kyung] Yonsei Univ, Dept Neurol, Coll Med, Seoul, South Korea.
C3 Ewha Womans University; Yonsei University; Yonsei University Health
   System; Yonsei University; Yonsei University Health System
RP Chu, MK (corresponding author), Yonsei Univ, Dept Neurol, Coll Med, Seoul, South Korea.
EM chumk@yonsei.ac.kr
OI Chu, Min Kyung/0000-0001-6221-1346; Park, Chae Gyu/0000-0003-1906-1308
FU Korea Health Technology R&D Project through the Korea Health Industry
   Development Institute (KHIDI) - Ministry of Health & Welfare, Republic
   of Korea;  [HVC22CO106]
FX Funding This research was supported by a grant from the Korea Health
   Technology R&D Project through the Korea Health Industry Development
   Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic
   of Korea (Grant No.: HVC22CO106).
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NR 53
TC 7
Z9 7
U1 0
U2 5
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2295
J9 FRONT NEUROL
JI Front. Neurol.
PD OCT 12
PY 2022
VL 13
AR 1021065
DI 10.3389/fneur.2022.1021065
PG 10
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 5U7AR
UT WOS:000876696100001
PM 36313504
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Masarone, M
   Rosato, V
   Dallio, M
   Gravina, AG
   Aglitti, A
   Loguercio, C
   Federico, A
   Persico, M
AF Masarone, Mario
   Rosato, Valerio
   Dallio, Marcello
   Gravina, Antonietta Gerarda
   Aglitti, Andrea
   Loguercio, Carmelina
   Federico, Alessandro
   Persico, Marcello
TI Role of Oxidative Stress in Pathophysiology of Nonalcoholic Fatty Liver
   Disease
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Review
ID ENDOPLASMIC-RETICULUM STRESS; NITRIC-OXIDE SYNTHASE; UNFOLDED PROTEIN
   RESPONSE; CYTOCHROME-P450 2E1; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   HEPATIC STEATOSIS; DNA-DAMAGE; LIPID-PEROXIDATION; HEME OXYGENASE-1
AB Liver steatosis without alcohol consumption, namely, nonalcoholic fatty liver disease (NAFLD), is a common hepatic condition that encompasses a wide spectrum of presentations, ranging from simple accumulation of triglycerides in the hepatocytes without any liver damage to inflammation, necrosis, ballooning, and fibrosis (namely, nonalcoholic steatohepatitis) up to severe liver disease and eventually cirrhosis and/or hepatocellular carcinoma. The pathophysiology of fatty liver and its progression is influenced by multiple factors (environmental and genetics), in a "multiple parallel-hit model," in which oxidative stress plays a very likely primary role as the starting point of the hepatic and extrahepatic damage. The aim of this review is to give a comprehensive insight on the present researches and findings on the role of oxidative stress mechanisms in the pathogenesis and pathophysiology of NAFLD. With this aim, we evaluated the available data in basic science and clinical studies in this field, reviewing the most recent works published on this topic.
C1 [Masarone, Mario; Rosato, Valerio; Gravina, Antonietta Gerarda; Aglitti, Andrea; Persico, Marcello] Univ Med Salerno, Internal Med & Hepatol Div, Dept Med, Salerno, Italy.
   [Dallio, Marcello; Loguercio, Carmelina; Federico, Alessandro] Univ Campania Luigi Vanvitelli, Hepatogastroenterol Div, Naples, Italy.
C3 Universita della Campania Vanvitelli
RP Masarone, M (corresponding author), Univ Med Salerno, Internal Med & Hepatol Div, Dept Med, Salerno, Italy.
EM mmasarone@unisa.it
RI Dallio, Marcello/ABG-7693-2020; Aglitti, Andrea/Y-1705-2019; persico,
   marcello/AAB-3562-2019; Gravina, Antonietta Gerarda/AAC-1528-2019;
   Federico, Alessandro/AAB-3893-2019; Rosato, Valerio/ABB-9874-2020;
   Masarone, Mario/H-8633-2017
OI DALLIO, MARCELLO/0000-0003-4153-815X; Masarone,
   Mario/0000-0003-0550-8201; Gravina, Antonietta
   Gerarda/0000-0001-8049-0115; Rosato, Valerio/0000-0002-3584-2414;
   Federico, Alessandro/0000-0002-0885-0793; Persico,
   Marcello/0000-0002-1399-6498; Aglitti, Andrea/0000-0001-9742-0172
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NR 117
TC 506
Z9 525
U1 6
U2 95
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PY 2018
VL 2018
AR 9547613
DI 10.1155/2018/9547613
PG 14
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA GK6BJ
UT WOS:000436265900001
PM 29991976
OA hybrid, Green Published, Green Submitted
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Alshehri, T
   Mook-Kanamori, DO
   de Mutsert, R
   Penninx, BWJH
   Rosendaal, FR
   le Cessie, S
   Milaneschi, Y
AF Alshehri, Tahani
   Mook-Kanamori, Dennis O.
   de Mutsert, Renee
   Penninx, Brenda W. J. H.
   Rosendaal, Frits R.
   le Cessie, Saskia
   Milaneschi, Yuri
TI The association between adiposity and atypical energy-related symptoms
   of depression: A role for metabolic dysregulations
SO BRAIN BEHAVIOR AND IMMUNITY
LA English
DT Article
DE Genetic risk score; Depression; Metabolic Syndrome; Body Fat
   Distribution; Body Mass Index; Homeostasis
ID BODY-MASS INDEX; MAJOR DEPRESSION; OBESITY; FEATURES
AB Background: Adiposity has been shown to be linked with atypical energy-related symptoms (AES) of depression. We used genomics to separate the effect of adiposity from that of metabolic dysregulations to examine whether the link between obesity and AES is dependent on the presence of metabolic dysregulations. Method: Data were from NEO (n = 5734 individuals) and NESDA (n = 2238 individuals) cohorts, in which the Inventory of Depressive Symptomatology (IDS-SR30) was assessed. AES profile was based on four symptoms: increased appetite, increased weight, low energy level, and leaden paralysis. We estimated associations between AES and two genetic risk scores (GRS) indexing increasing total body fat with (metabolically unhealthy adiposity, GRS-MUA) and without (metabolically healthy adiposity, GRS-MHA) metabolic dysregulations.Results: We validated that both GRS-MUA and GRS-MHA were associated with higher total body fat in NEO study, but divergently associated with biomarkers of metabolic health (e.g., fasting glucose and HDL-cholesterol) in both cohorts. In the pooled results, per standard deviation, GRS-MUA was specifically associated with a higher AES score (beta = 0.03, 95%CI: 0.01; 0.05), while there was no association between GRS-MHA and AES (beta =-0.01, 95%CI:-0.03; 0.01).Conclusion: These results suggest that the established link between adiposity and AES profile emerges in the presence of metabolic dysregulations, which may represent the connecting substrate between the two conditions.
C1 [Alshehri, Tahani; Mook-Kanamori, Dennis O.; de Mutsert, Renee; Rosendaal, Frits R.; le Cessie, Saskia] Leiden Univ, Dept Clin Epidemiol, Med Ctr, Leiden, Netherlands.
   [Mook-Kanamori, Dennis O.] Leiden Univ, Dept Publ Hlth & Primary Care, Med Ctr, Leiden, Netherlands.
   [Penninx, Brenda W. J. H.; Milaneschi, Yuri] Vrije Univ, Amsterdam Publ Hlth Res Inst, Dept Psychiat, Amsterdam Neurosci,Amsterdam UMC, Amsterdam, Netherlands.
   [le Cessie, Saskia] Leiden Univ, Dept Biomed Data Sci, Med Ctr, Leiden, Netherlands.
   [Alshehri, Tahani] Leiden Univ Med Ctr LUMC, Albinusdreef 2,Postzone C7-P,Postbus 9600, NL-2300 RC Leiden, Netherlands.
C3 Leiden University - Excl LUMC; Leiden University; Leiden University
   Medical Center (LUMC); Leiden University - Excl LUMC; Leiden University;
   Leiden University Medical Center (LUMC); University of Amsterdam; Vrije
   Universiteit Amsterdam; Leiden University - Excl LUMC; Leiden
   University; Leiden University Medical Center (LUMC); Leiden University;
   Leiden University Medical Center (LUMC)
RP Alshehri, T (corresponding author), Leiden Univ Med Ctr LUMC, Albinusdreef 2,Postzone C7-P,Postbus 9600, NL-2300 RC Leiden, Netherlands.
EM t.m.alshehri@lumc.nl
RI Penninx, Brenda/S-7627-2017; Rosendaal, Frits/Q-3842-2017; le+Cessie,
   Saskia/HGC-8966-2022; Alshehri, Tahani/IUP-1119-2023
OI Milaneschi, Yuri/0000-0002-3697-6617
FU Geestkracht program of the Netherlands Organization for Health Research
   and Development (ZonMw) [10-000-1002]; VU University Medical Center; GGZ
   in Geest; Leiden University Medical Center; Leiden University; GGZ
   Rivierduinen; University Medical Center Groningen; University of
   Groningen; Lentis; GGZ Friesland; GGZ Drenthe; Rob Giel
   Onderzoekscentrum; Leiden University, Research Profile Area Vascular and
   Regenerative Medicine; Dutch Science Organization (ZonMW-VENI Grant)
   [916.14.023]
FX Acknowledgments NESDA The infrastructure for the NESDA study (
   www.nesda.nl) is funded through the Geestkracht program of the
   Netherlands Organization for Health Research and Development (ZonMw,
   grant number: 10-000-1002) and financial contributions by participating
   universities and mental health care organizations (VU University Medical
   Center, GGZ in Geest, Leiden University Medical Center, Leiden
   University, GGZ Rivierduinen, University Medical Center Groningen,
   University of Groningen, Lentis, GGZ Friesland, GGZ Drenthe, Rob Giel
   Onderzoekscentrum) . NEO study The NEO study is supported by the
   participating Departments, Division, and Board of Directors of the
   Leiden University Medical Center, and by the Leiden University, Research
   Profile Area Vascular and Regenerative Medicine. DOM-K is supported by
   Dutch Science Organization (ZonMW-VENI Grant No. 916.14.023) . We
   express our gratitude to all participants of the Netherlands
   Epidemiology of Obesity (NEO) study, in addition to all participating
   general practi-tioners. We furthermore thank P.R. van Beelen and all
   research nurses for collecting the data, P.J. Noordijk and her team for
   sample handling and storage, and I. de Jonge for data management of the
   NEO study. Finally, we would like to express our gratitude to Dr R.
   Noordam for extracting the genetics data in this study and answering our
   related questions.
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NR 33
TC 2
Z9 2
U1 0
U2 6
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0889-1591
EI 1090-2139
J9 BRAIN BEHAV IMMUN
JI Brain Behav. Immun.
PD FEB
PY 2023
VL 108
BP 197
EP 203
DI 10.1016/j.bbi.2022.12.005
EA DEC 2022
PG 7
WC Immunology; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Neurosciences & Neurology; Psychiatry
GA 7K2QD
UT WOS:000905129500001
PM 36494049
OA hybrid, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Ertas, F
   Kaya, H
   Acet, H
   Çil, H
   Akyüz, A
   Islamoglu, Y
   Tekbas, E
   Aritürk, Z
   Aydin, M
   Soydinç, S
AF Ertas, Faruk
   Kaya, Hasan
   Acet, Halit
   Cil, Habib
   Akyuz, Abdurrahman
   Islamoglu, Yahya
   Tekbas, Ebru
   Ariturk, Zuhal
   Aydin, Mesut
   Soydinc, Serdar
TI Increased echocardiographic epicardial fat thickness is related to
   impaired diurnal blood pressure profiles
SO BLOOD PRESSURE
LA English
DT Article
DE Dipper; echocardiography; epicardial fat thickness; hypertension;
   non-dipper
ID ADIPOSE-TISSUE; INSULIN-RESISTANCE; OXIDATIVE STRESS; ORGAN DAMAGE;
   HYPERTENSION; INFLAMMATION; PATTERNS; DECREASE; VOLUMES
AB Objective. Epicardial fat has been proposed as a new cardiometabolic risk factor. Although epicardial fat thickness (EFT) is associated with hypertension, the relationship between diurnal blood pressure profiles and EFT is still unknown. The purpose of this study is to investigate the association between the echocardiographic EFT and diurnal blood pressure profiles in hypertensive patients. Methods. After the ambulatory blood pressures of 123 patients were monitored, they were divided into three groups according to the clinical diagnoses: 41 patients (33.3%) were in the normotensive group, 40 patients (32.5%) were in the dipper hypertensive group and 42 patients (34.1%) were in the non-dipper hypertensive group. All participants underwent transthoracic echocardiography and ambulatory blood pressure monitoring to measure the EFT and blood pressure responses. Results. The mean EFT measurements of the dipper group were significantly higher than the normotensive group (6.5 +/- 0.6 vs 5.8 +/- 0.6; p < 0.0001). On the other hand, the mean EFTs of the non-dipper group were also significantly higher than the dipper group (7.4 +/- 0.7 vs 6.5 +/- 0.6, p < 0.0001). An EFT of >= 7 mm predicted the non-dipper profile in hypertensive patients with 74% sensitivity and 71% specificity (receiving operator characteristic area under the curve: 0.826, 95% CI 0.738-0.913; p < 0.0001). EFT was associated with both dipper (OR 8.9, 95% CI 3.03-26.3; p < 0.0001) and non-dipper blood pressure profiles (OR 12.3, 95% CI 1.75-86.31; p < 0.0001), and this relationship was also independent from all the risk factors. Conclusion. Echocardiographic EFT assessment is independently associated with impaired diurnal blood pressure profiles in the hypertensive individuals. Thus, the echocardiographic assessment of the EFT may be helpful in cardiometabolic risk stratification and therapeutic interventions.
C1 [Ertas, Faruk; Kaya, Hasan; Cil, Habib; Akyuz, Abdurrahman; Islamoglu, Yahya; Tekbas, Ebru; Ariturk, Zuhal; Aydin, Mesut; Soydinc, Serdar] Dicle Univ, Dept Cardiol, Fac Med, Diyarbakir, Turkey.
   [Acet, Halit] Diyarbakir Educ & Res Hosp, Dept Cardiol, Diyarbakir, Turkey.
C3 Dicle University; Diyarbakir Training & Research Hospital
RP Ertas, F (corresponding author), Dicle Univ, Dept Cardiol, Fac Med, Diyarbakir, Turkey.
EM farukertas@hotmail.com
RI Ertas, Faruk/N-6409-2013; akyüz, abdurrahman/IZQ-0738-2023; KAYA,
   HASAN/F-8496-2013
OI KAYA, HASAN/0000-0003-3923-4026
CR Cuspidi C, 2008, BLOOD PRESS MONIT, V13, P318, DOI 10.1097/MBP.0b013e32830d4bf8
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NR 32
TC 20
Z9 22
U1 0
U2 13
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
EI 1651-1999
J9 BLOOD PRESSURE
JI Blood Pressure
PD JUN
PY 2012
VL 21
IS 3
BP 202
EP 208
DI 10.3109/08037051.2011.649538
PG 7
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 939RO
UT WOS:000303831700010
PM 22229446
DA 2025-06-11
ER

PT J
AU Cai, XJ
   Li, X
   Li, L
   Huang, XZ
   Liu, YS
   Chen, L
   Zhang, K
   Wang, L
   Li, XN
   Song, JT
   Li, SZ
   Zhang, Y
   Zhang, M
AF Cai, Xiaojun
   Li, Xuan
   Li, Li
   Huang, Xiao-Zhen
   Liu, Yu-Sheng
   Chen, Liang
   Zhang, Ke
   Wang, Lin
   Li, Xiaonan
   Song, Jiantao
   Li, Shuzhen
   Zhang, Yun
   Zhang, Mei
TI Adiponectin reduces carotid atherosclerotic plaque formation in
   ApoE<SUP>-/-</SUP> mice: Roles of oxidative and nitrosative stress and
   inducible nitric oxide synthase
SO MOLECULAR MEDICINE REPORTS
LA English
DT Article
DE adiponectin; atherosclerosis; oxidative stress; nitrite/nitrate;
   inducible nitric oxide synthase
ID IMPROVES ENDOTHELIAL FUNCTION; ADIPOSE-SPECIFIC PROTEIN; TYPE-2 DIABETIC
   MICE; OXIDATIVE/NITRATIVE STRESS; HYPERLIPIDEMIC RATS; ADHESION
   MOLECULES; INSULIN-RESISTANCE; METABOLIC SYNDROME; SIGNALING PATHWAY;
   CORONARY-ARTERY
AB Adiponectin (APN) is an important anti-atherogenic adipocytokine. The aim of the present study was to investigate the role of adiponectin in atherosclerotic plaque formation and clarify its mechanisms. An atherosclerosis model was induced by in vivo perivascular constrictive silica collar placement on the left common carotid arteries in male apolipoprotein E-deficient (ApoE(-/-)) mice. All of the mice were fed a high-fat diet, and divided into phosphate-buffered saline, adenovirus (Ad)-beta-galactosidase and Ad-APN treatment groups. Compared with treatment of Ad-beta-gal or PBS, Ad-APN treatment markedly reduced inducible nitric oxide synthase (iNOS) protein expression, decreased in nitric oxide/superoxide production, blocked peroxynitrite formation and reversed the progression of atherosclerotic lesions. Adiponectin may be a natural molecule that reduces atherosclerosis by inhibiting iNOS and consequently diminishing oxidative/nitrative stress.
C1 [Cai, Xiaojun; Li, Xuan; Li, Li; Huang, Xiao-Zhen; Liu, Yu-Sheng; Chen, Liang; Zhang, Ke; Wang, Lin; Li, Xiaonan; Song, Jiantao; Zhang, Yun; Zhang, Mei] Shandong Univ, Qilu Hosp, Chinese Minist Educ, Key Lab Cardiovasc Remodeling & Funct Res, Jinan 250012, Shandong, Peoples R China.
   [Cai, Xiaojun; Li, Xuan; Li, Li; Huang, Xiao-Zhen; Liu, Yu-Sheng; Chen, Liang; Zhang, Ke; Wang, Lin; Li, Xiaonan; Song, Jiantao; Zhang, Yun; Zhang, Mei] Shandong Univ, Qilu Hosp, Chinese Minist Publ Hlth, Jinan 250012, Shandong, Peoples R China.
   [Cai, Xiaojun; Li, Li; Li, Shuzhen] Shandong Univ, Dept Cardiol, Jinan Cent Hosp, Jinan 250014, Shandong, Peoples R China.
   [Li, Xuan] Weifang Tradit Chinese Med Hosp, Dept Cardiol, Weifang 261041, Shandong, Peoples R China.
   [Huang, Xiao-Zhen] Jinan Huaiyin Hosp, Dept Cardiol, Jinan 250021, Shandong, Peoples R China.
   [Liu, Yu-Sheng] Shandong Univ, Hosp 2, Dept Cardiol, Jinan 250033, Shandong, Peoples R China.
C3 Ministry of Education - China; Shandong University; Shandong University;
   Shandong University; Shandong First Medical University & Shandong
   Academy of Medical Sciences; Shandong University
RP Zhang, M (corresponding author), Shandong Univ, Qilu Hosp, Chinese Minist Educ, Key Lab Cardiovasc Remodeling & Funct Res, 107 Wenhua Xi Rd, Jinan 250012, Shandong, Peoples R China.
EM daixh@vip.sina.com
RI Cai, Xiaojun/C-1864-2015; Li, Linlin/M-8350-2014
FU National Basic Research Program of China (973 Program) [2011CB503906];
   Development Program of China (863 Program) [2007AA02Z448]; National
   Natural Science Foundation of China [30728025, 30970709]; National
   Natural Science Funds for Young Scholar [81200211]; Shandong Young
   Scientists Award Fund [BS2012SW003]; Scientific and technology
   Development program of Jinan [201003125, 200905035]
FX This study was supported by The National Basic Research Program of China
   (973 Program, 2011CB503906), Development Program of China (863 Program,
   2007AA02Z448), the National Natural Science Foundation of China (nos.
   30728025 and 30970709), National Natural Science Funds for Young Scholar
   (no. 81200211), grants from the Shandong Young Scientists Award Fund
   (no. BS2012SW003) and grants from Scientific and technology Development
   program of Jinan (nos. 201003125 and 200905035).
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NR 35
TC 27
Z9 34
U1 0
U2 23
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1791-2997
EI 1791-3004
J9 MOL MED REP
JI Mol. Med. Rep.
PD MAR
PY 2015
VL 11
IS 3
BP 1715
EP 1721
DI 10.3892/mmr.2014.2947
PG 7
WC Oncology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Research & Experimental Medicine
GA CD2OA
UT WOS:000350917700022
PM 25395016
OA Green Published, hybrid, Green Submitted
DA 2025-06-11
ER

PT J
AU Bhat, PV
   Vinod, V
   Priyanka, AN
   Kamath, A
AF Bhat, Parvati, V
   Vinod, Vinutha
   Priyanka, Alluri Naga
   Kamath, Asha
TI Maternal serum lipid levels, oxidative stress and antioxidant activity
   in pre-eclampsia patients from Southwest India
SO PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR
   HEALTH
LA English
DT Article
DE Fasting glucose; Fasting insulin; Insulin resistance; Oxidative stress;
   Pre-eclampsia
ID DIABETES-MELLITUS; PREGNANCY; COMPLICATIONS; DISORDERS
AB Objective: A study was carried out to evaluate the effects of metabolic syndrome components and oxidative stress factors among preeclamptic women from South West India.
   Study design: A case-control study was carried out by enrolling fifty pre-eclampsia cases and hundred low-risk pregnant women within the age group of 18-40 years, at 28-34 weeks of pregnancy. The fasting glucose level, fasting insulin level, insulin resistance, total cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL), malondialdehyde, the ferric reducing ability of plasma (FRAP assay), cardiac output and aortic wall distensibility were measured.
   Main outcome measures: There was a significant rise in the fasting blood glucose, fasting insulin, insulin resistance levels, total cholesterol, triglycerides, LDL, and antioxidant levels in pre-eclamptic women (p < 0.001). The cardiac output and aortic wall distensibility were observed to be low in the cases.
   Conclusion: We conclude that abnormal lipid metabolism and high lipid peroxide concentrations observed in pre-eclampsia may result in oxidative stress and vascular dysfunction.
C1 [Bhat, Parvati, V; Priyanka, Alluri Naga] Manipal Acad Higher Educ, MMMC, Dr TMA Pai Hosp, Dept Obstet & Gynecol, Manipal 576104, Karnataka, India.
   [Vinod, Vinutha] Manipal Acad Higher Educ, MMMC, Dr TMA Pai Hosp, Manipal 576104, Karnataka, India.
   [Kamath, Asha] Manipal Acad Higher Educ, Prasanna Sch Publ Hlth, Dept Stat, Manipal 576104, Karnataka, India.
C3 Manipal Academy of Higher Education (MAHE); Manipal Academy of Higher
   Education (MAHE); Manipal Academy of Higher Education (MAHE)
RP Bhat, PV (corresponding author), Manipal Acad Higher Educ, MMMC, Dr TMA Pai Hosp, Dept Obstet & Gynecol, Manipal 576104, Karnataka, India.
EM parvati.bhat@manipal.edu; asha.kamath@manipal.edu
OI vinod, vinutha/0000-0001-8768-3251
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NR 24
TC 7
Z9 7
U1 0
U2 1
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 2210-7789
J9 PREGNANCY HYPERTENS
JI Pregnancy Hypertens.
PD JAN
PY 2019
VL 15
BP 130
EP 133
DI 10.1016/j.preghy.2018.12.010
PG 4
WC Obstetrics & Gynecology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology; Cardiovascular System & Cardiology
GA HM9LF
UT WOS:000459805100021
PM 30825910
DA 2025-06-11
ER

PT J
AU Saiki, M
   Robbins, W
   Tolentino, DA
   Macey, PM
   Nakata, A
   Li, J
AF Saiki, Mayumi
   Robbins, Wendie
   Tolentino, Dante Anthony
   Macey, Paul M.
   Nakata, Akinori
   Li, Jian
TI Associations of work-family conflict with changes in metabolic risk
   factors: a four-year longitudinal study
SO INDUSTRIAL HEALTH
LA English
DT Article
DE Longitudinal study; Occupational stress; Work-family conflict;
   Cardiometabolic risk factors; Cholesterol
ID JOB DEMANDS; HEALTH; STRESS; STRAIN; JAPAN
AB Cardiovascular disease (CVD) is becoming prevalent among younger people who have dual roles at both work and home. A possible contributor to CVD is conflict between work and home life. Thus, this study investigated the impact of work-to-family conflict (WFC) and family- to-work conflict (FWC) on metabolic risk factors. We used longitudinal data with a 4-yr interval from the Midlife in Japan study. 152 participants who were employed at baseline without missing variables of interest were included. We assessed the associations of baseline WFC and FWC with changes in metabolic risk factors between baseline and follow-up using Generalized Estimating Equations. After adjusting for baseline sociodemographic, work and family-related, and lifestyle factors, the fully adjusted model showed WFC was significantly associated with changes in low- density lipoprotein cholesterol (LDL-C) and Total cholesterol (TC)/high-density lipoprotein cholesterol (HDL-C) ratio. However, FWC was not significantly associated with changes in any metabolic risk factors. Our findings indicated a significant impact of WFC on LDL-C and TC/HDL-C ratio but no significant impact of FWC on metabolic health. Since these metabolic risk factors cause CVD, understanding the physiological responses to occupational psychosocial stress could help create primary prevention interventions and assess their effects on workers' metabolic health.
C1 [Saiki, Mayumi; Robbins, Wendie; Tolentino, Dante Anthony; Macey, Paul M.; Li, Jian] Univ Calif Los Angeles, Sch Nursing, Los Angeles, CA 90095 USA.
   [Robbins, Wendie; Li, Jian] Univ Calif Los Angeles, Fielding Sch Publ Hlth, Dept Environm Hlth Sci, Los Angeles, CA 90095 USA.
   [Nakata, Akinori] Int Univ Hlth & Welf, Grad Sch Med, Otawara, Japan.
   [Li, Jian] Univ Calif Los Angeles, Fielding Sch Publ Hlth, Dept Epidemiol, Los Angeles, CA 90095 USA.
C3 University of California System; University of California Los Angeles;
   University of California System; University of California Los Angeles;
   International University of Health & Welfare; University of California
   System; University of California Los Angeles
RP Li, J (corresponding author), Univ Calif Los Angeles, Sch Nursing, Los Angeles, CA 90095 USA.; Li, J (corresponding author), Univ Calif Los Angeles, Fielding Sch Publ Hlth, Dept Environm Hlth Sci, Los Angeles, CA 90095 USA.; Li, J (corresponding author), Univ Calif Los Angeles, Fielding Sch Publ Hlth, Dept Epidemiol, Los Angeles, CA 90095 USA.
EM jianli2019@ucla.edu
RI Tolentino, Dante Anthony/HNQ-6991-2023; Nakata, Akinori/HHC-4947-2022;
   Macey, Paul/B-5037-2008
OI Macey, Paul/0000-0003-4093-7458; Nakata, Akinori/0000-0003-3008-4615
FU U.S. National Institute on Aging [5R37AG027343]; National Institute for
   Occupational Safety and Health (NIOSH) Occupational and Environmental
   Health Nursing Program of the Southern California Education and Research
   Center (SCERC) from the U.S. Centers for Disease Control and Prevention
   (CDC) [T42 OH008412]
FX The Midlife in Japan (MIDJA) Study was supported by a grant from the
   U.S. National Institute on Aging (5R37AG027343) . MS was supported by
   the National Institute for Occupational Safety and Health (NIOSH)
   Occupational and Environmental Health Nursing Program of the Southern
   California Education and Research Center (SCERC) (Grant Agreement
   Number: T42 OH008412) from the U.S. Centers for Disease Control and
   Prevention (CDC) . Its contents are solely the responsibility of the
   authors and do not necessarily represent the official view of the U.S.
   CDC.
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NR 33
TC 0
Z9 0
U1 1
U2 1
PU NATL INST OCCUPATIONAL SAFETY & HEALTH, JAPAN
PI KAWASAKI KANAGAWA
PA 21-1 NAGAO 6-CHOME TAMA-KU, KAWASAKI KANAGAWA, 214, JAPAN
SN 0019-8366
EI 1880-8026
J9 IND HEALTH
JI Ind. Health
PY 2024
VL 62
IS 6
BP 367
EP 376
DI 10.2486/indhealth.2024-0115
PG 10
WC Environmental Sciences; Public, Environmental & Occupational Health;
   Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health; Toxicology
GA N4N2G
UT WOS:001364117800003
PM 39261023
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Oo, WJ
   Lim, CL
   Goh, MH
   Koh, RY
AF Oo, Wei Jet
   Lim, Chooi Ling
   Goh, Mun Hon
   Koh, Rhun Yian
TI Serum Cortisol and Cardiovascular Disease Risk - A Potential Biomarker
SO CURRENT CARDIOLOGY REVIEWS
LA English
DT Review
DE Serum cortisol; cardiovascular; stress; hormone; biomarker; mechanistic
   parameters
ID CUSHINGS-SYNDROME; GENE-EXPRESSION; ADIPOSE-TISSUE; ORAL
   GLUCOCORTICOIDS; GLUCOSE-METABOLISM; ADRENAL-TUMORS; ACTIVE DISEASE;
   CHRONIC STRESS; PHASE-III; LINC 3
AB Cardiovascular disease (CVD), the leading cause of death globally, poses a significant burden on the healthcare sector. Its association with stress and Cushing's Syndrome has driven cortisol, the 'stress hormone,' to be a potential candidate in determining CVD risk. Cortisol synthesis and release through the hypothalamic-pituitary-adrenal (HPA) axis are regulated by several hormones and receptors involved in the pathological cascade towards CVD. Evidence suggests that metabolic syndrome plays a major role in cortisol-mediated CVD risk. On the other hand, non-metabolic features are also implicated when the association between cortisol and CVD risk remains significant upon normalisation of metabolic parameters. Correspondingly, the treatment for hypercortisolism is often found effective in lowering CVD risk. Despite available evidence, several factors continue to hinder the clinical use of cortisol as a risk biomarker for CVD. This review provides an insight into the role of serum cortisol in CVD progression and risk, with emphasis on the mechanistic features and parameters.
C1 [Oo, Wei Jet; Lim, Chooi Ling; Koh, Rhun Yian] IMU Univ, Sch Hlth Sci, Div Appl Biomed Sci & Biotechnol, 126 Jalan Jalil Perkasa 19, Kuala Lumpur 57000, Malaysia.
   [Goh, Mun Hon] Natl Heart Inst, Lab & Blood Serv Dept, 145 Jalan Tun Razak, Kuala Lumpur 50400, Malaysia.
C3 Institute Jantung Negara
RP Lim, CL (corresponding author), IMU Univ, Sch Hlth Sci, Div Appl Biomed Sci & Biotechnol, 126 Jalan Jalil Perkasa 19, Kuala Lumpur 57000, Malaysia.
EM chooi_linglim@imu.edu.my
RI Koh, Rhun Yian/KHZ-6083-2024
OI Lim, Chooi Ling/0000-0002-2926-892X
FU School of Health Sciences, IMU University, Malaysia
FX This work was supported by the School of Health Sciences, IMU
   University, Malaysia.
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NR 119
TC 0
Z9 0
U1 0
U2 0
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1573-403X
EI 1875-6557
J9 CURR CARDIOL REV
JI Curr. Cardiol. Rev.
PY 2025
VL 21
IS 3
AR E1573403X328499
DI 10.2174/011573403X328499241106064553
PG 11
WC Cardiac & Cardiovascular Systems
WE Emerging Sources Citation Index (ESCI)
SC Cardiovascular System & Cardiology
GA 2JS0S
UT WOS:001484278100008
PM 39754772
DA 2025-06-11
ER

PT J
AU Groer, M
   Murphy, R
   Bunnell, W
   Salomon, K
   Van Eepoel, J
   Rankin, B
   White, K
   Bykowski, C
AF Groer, Maureen
   Murphy, Randall
   Bunnell, William
   Salomon, Kristin
   Van Eepoel, Jeanne
   Rankin, Blake
   White, Kristi
   Bykowski, Cathy
TI Salivary Measures of Stress and Immunity in Police Officers Engaged in
   Simulated Critical Incident Scenarios
SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
LA English
DT Article
ID INTERLEUKIN-6 LEVELS; METABOLIC SYNDROME; COLLECTION METHOD;
   IMMUNOGLOBULIN-A; ALPHA-AMYLASE; CORTISOL; SERUM; WORK; ATHEROSCLEROSIS;
   EXERCISE
AB Objective: This research investigated the effects of a critical incident lethal force scenario on a panel of salivary biomarkers, measured at baseline and then at 10 and 30 minutes postscenario, in 141 law enforcement volunteer officers. Methods: Officers were randomly assigned to two virtual reality scenarios. One scenario was brief and involved a police officer chasing a suspect on a motorcycle, confronting the suspect who draws a gun and shoots the police officer. The other scenario involved a lengthy chase by the police officer through a workplace of an armed perpetrator ultimately engaging in gunfire with the police officer. Saliva was analyzed for cortisol, secretory immunoglobulin A (sIgA), interleukin-6, and alpha-amylase concentrations. Results: The "workplace" scenario produced the largest responses in biomarkers, with significant rises in cortisol, interleukin-6, alpha-amylase, and secretory immunoglobulin A. These data suggest that virtual reality can produce stress and immune effects. Conclusions: This research suggests that virtual reality scenarios produce physiologic stress responses, mimicking occupational stress.
C1 [Groer, Maureen; Van Eepoel, Jeanne; Rankin, Blake] Univ S Florida, Coll Nursing, Tampa, FL 33612 USA.
   [Salomon, Kristin; White, Kristi; Bykowski, Cathy] Univ S Florida, Dept Psychol, Tampa, FL 33612 USA.
   [Murphy, Randall; Bunnell, William] Meggitts Training Syst Inc, Atlanta, GA USA.
C3 State University System of Florida; University of South Florida; State
   University System of Florida; University of South Florida
RP Groer, M (corresponding author), Univ S Florida, Coll Nursing, 12910 Bruce B Downs Blvd, Tampa, FL 33612 USA.
EM mgroer@health.usf.edu
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NR 30
TC 55
Z9 67
U1 0
U2 16
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1076-2752
J9 J OCCUP ENVIRON MED
JI J. Occup. Environ. Med.
PD JUN
PY 2010
VL 52
IS 6
BP 595
EP 602
DI 10.1097/JOM.0b013e3181e129da
PG 8
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA 608FM
UT WOS:000278568500004
PM 20523239
DA 2025-06-11
ER

PT J
AU Arnold, SE
   Lucki, I
   Brookshire, BR
   Carlson, GC
   Browne, CA
   Kazi, H
   Bang, S
   Choi, BR
   Chen, Y
   McMullen, MF
   Kim, SF
AF Arnold, Steven E.
   Lucki, Irwin
   Brookshire, Bethany R.
   Carlson, Gregory C.
   Browne, Caroline A.
   Kazi, Hala
   Bang, Sookhee
   Choi, Bo-Ran
   Chen, Yong
   McMullen, Mary F.
   Kim, Sangwon F.
TI High fat diet produces brain insulin resistance, synaptodendritic
   abnormalities and altered behavior in mice
SO NEUROBIOLOGY OF DISEASE
LA English
DT Article
DE Insulin; Insulin receptor substrate 1; Alct; GSK3; mTOR; IPMK; Synapse;
   Spine; Working memory
ID TYPE-2 DIABETES-MELLITUS; HIPPOCAMPAL SYNAPTIC PLASTICITY; ACTIVATED
   PROTEIN-KINASE; LONG-TERM POTENTIATION; METABOLIC SYNDROME; INDUCED
   OBESITY; FOOD-INTAKE; MEMORY; DEPRESSION; RECEPTOR
AB Insulin resistance and other features of the metabolic syndrome are increasingly recognized for their effects on cognitive health. To ascertain mechanisms by which this occurs, we fed mice a very high fat diet (60% kcal by fat) for 17 days or a moderate high fat diet (HFD, 45% kcal by fat) for 8 weeks and examined changes in brain insulin signaling responses, hippocampal synaptodendritic protein expression, and spatial working memory. Compared to normal control diet mice, cerebral cortex tissues of HFD mice were insulin-resistant as evidenced by failed activation of Akt, S6 and GSK3 beta with ex-vivo insulin stimulation. Importantly, we found that expression of brain IPMK, which is necessary for mTOR/Akt signaling, remained decreased in HFD mice upon activation of AMPK. HFD mouse hippocampus exhibited increased expression of serine-phosphorylated insulin receptor substrate 1 (IRS1-pS(616)), a marker of insulin resistance, as well as decreased expression of PSD-95, a scaffolding protein enriched in post-synaptic densities, and synaptopodin, an actin-associated protein enriched in spine apparatuses. Spatial working memory was impaired as assessed by decreased spontaneous alternation in a T-maze. These findings indicate that HFD is associated with telencephalic insulin resistance and deleterious effects on synaptic integrity and cognitive behaviors. (C) 2014 Elsevier Inc. All rights reserved.
C1 [Arnold, Steven E.; Lucki, Irwin; Brookshire, Bethany R.; Carlson, Gregory C.; Browne, Caroline A.; Kazi, Hala; Bang, Sookhee; Choi, Bo-Ran; Chen, Yong; McMullen, Mary F.; Kim, Sangwon F.] Univ Penn, Dept Psychiat, Ctr Neurobiol & Behav, Philadelphia, PA 19104 USA.
C3 University of Pennsylvania
RP Arnold, SE (corresponding author), 2205 Translat Res Labs, 125 Soth 31st St, Philadelphia, PA 19104 USA.
EM steven.arnold@uphs.upenn.edu; sangwonk@mail.med.upenn.edu
RI Browne, Caroline/ADZ-5051-2022; Arnold, Steven/J-7546-2012; Lucki,
   Irwin/AAX-6061-2021
OI Browne, Caroline/0000-0001-7463-7870; Choi, Bo-Ran/0000-0002-1366-4688
FU NIH [R01 AG039478, RO1 DK084336, R01 MH086599, T32 MH14654]; University
   of Pennsylvania Institute on Aging; Allen H and Selma W. Berkman
   Charitable Trust; BrightFocus Foundation
FX This work was supported by grants from the NIH R01 AG039478 RO1
   DK084336, R01 MH086599 and T32 MH14654, the Allen H and Selma W. Berkman
   Charitable Trust, the BrightFocus Foundation and pilot grants from the
   University of Pennsylvania Institute on Aging.
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NR 86
TC 248
Z9 285
U1 1
U2 62
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0969-9961
EI 1095-953X
J9 NEUROBIOL DIS
JI Neurobiol. Dis.
PD JUL
PY 2014
VL 67
BP 79
EP 87
DI 10.1016/j.nbd.2014.03.011
PG 9
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA AH9PU
UT WOS:000336475100009
PM 24686304
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Florczak, E
   Prejbisz, A
   Szwench-Pietrasz, E
   Sliwinski, P
   Bielen, P
   Klisiewicz, A
   Michalowska, I
   Warchol, E
   Januszewicz, M
   Kala, M
   Witkowski, A
   Wiecek, A
   Narkiewicz, K
   Somers, VK
   Januszewicz, A
AF Florczak, E.
   Prejbisz, A.
   Szwench-Pietrasz, E.
   Sliwinski, P.
   Bielen, P.
   Klisiewicz, A.
   Michalowska, I.
   Warchol, E.
   Januszewicz, M.
   Kala, M.
   Witkowski, A.
   Wiecek, A.
   Narkiewicz, K.
   Somers, V. K.
   Januszewicz, A.
TI Clinical characteristics of patients with resistant hypertension: the
   RESIST-POL study
SO JOURNAL OF HUMAN HYPERTENSION
LA English
DT Article
DE resistant hypertension; obstructive sleep apnea; primary aldosteronism;
   renal artery stenosis; metabolic syndrome
ID OBSTRUCTIVE SLEEP-APNEA; PROFESSIONAL-EDUCATION-COMMITTEE;
   BLOOD-PRESSURE; PRIMARY ALDOSTERONISM; CARDIOVASCULAR-DISEASE;
   SCIENTIFIC STATEMENT; WHITE SUBJECTS; UNITED-STATES; PREVALENCE;
   ASSOCIATION
AB Recent studies indicate that resistant hypertension (RHTN) is present in about 12% of the treated hypertensive population. However, patients with true RHTN (confirmed out of the office) have not been widely studied. We prospectively studied 204 patients (123 male, 81female, mean age 48.4 years, range 19-65 years) with truly RHTN (ambulatory daytime mean blood pressure >135/85 mm Hg). We evaluated the frequency of obstructive sleep apnea (OSA), renal artery stenosis (RAS), primary aldosteronism (PA) and other secondary forms of hypertension (HTN) and conditions. Mild, moderate and severe OSA were present in 55 (27.0%), 38 (18.6%) and 54 (26.5%) patients, respectively. Secondary forms of HTN were diagnosed in 49 patients (24.0%), the most frequent being PA (15.7%) and RAS (5.4%). Metabolic syndrome (MS) was present in 65.7% of patients. Excessive sodium excretion was evident in 33.3% of patients and depression in 36.8% patients. In patients with RHTN, OSA and MS were the most frequent conditions, frequently overlapping with each other and also with PA. Our data indicate that in the vast majority of patients with truly RHTN, at least one of three co-morbidities-OSA, MS and PA-is present. Other conditions, even though less frequent, should also be taken into the consideration.
C1 [Florczak, E.; Prejbisz, A.; Szwench-Pietrasz, E.; Warchol, E.; Januszewicz, A.] Inst Cardiol, Dept Hypertens, PL-04628 Warsaw, Poland.
   [Sliwinski, P.; Bielen, P.] Inst TB & Lung Dis, Dept Resp Med 4, Warsaw, Poland.
   [Klisiewicz, A.] Inst Cardiol, Dept Congenital Heart Dis, PL-04628 Warsaw, Poland.
   [Michalowska, I.] Inst Cardiol, Dept Radiol, PL-04628 Warsaw, Poland.
   [Januszewicz, M.] Med Univ Warsaw, Dept Clin Radiol 2, Warsaw, Poland.
   [Kala, M.] Inst Forens Res, Krakow, Poland.
   [Witkowski, A.] Inst Cardiol, Dept Intervent Cardiol & Angiol, PL-04628 Warsaw, Poland.
   [Wiecek, A.] Med Univ Silesia, Dept Nephrol Endocrinol & Metab Dis, Katowice, Poland.
   [Narkiewicz, K.] Med Univ Gdansk, Dept Hypertens & Diabetol, Gdansk, Poland.
   [Somers, V. K.] Mayo Clin, Div Cardiovasc Dis, Rochester, MN USA.
   [Somers, V. K.] Mayo Clin, Div Hypertens, Rochester, MN USA.
C3 Institute of Cardiology - Poland; Institute of Cardiology - Poland;
   Institute of Cardiology - Poland; Medical University of Warsaw;
   Institute of Cardiology - Poland; Medical University of Silesia;
   Fahrenheit Universities; Medical University Gdansk; Mayo Clinic; Mayo
   Clinic
RP Prejbisz, A (corresponding author), Inst Cardiol, Dept Hypertens, Alpejska 42, PL-04628 Warsaw, Poland.
EM a.prejbisz@ikard.pl
RI Prejbisz, Aleksander/AAM-7672-2020
OI Prejbisz, Aleksander/0000-0001-7085-0244; Narkiewicz,
   Krzysztof/0000-0001-5949-5018; Januszewicz, Andrzej/0000-0002-1831-250X;
   Klisiewicz, Anna/0000-0001-5439-7443; Januszewicz,
   Magdalena/0000-0002-4725-3545
FU Ministry of Science and Higher Education [NN 402 190 335]
FX The study was supported by the Ministry of Science and Higher Education
   NN 402 190 335.
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NR 39
TC 85
Z9 97
U1 0
U2 12
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0950-9240
EI 1476-5527
J9 J HUM HYPERTENS
JI J. Hum. Hypertens.
PD NOV
PY 2013
VL 27
IS 11
BP 678
EP 685
DI 10.1038/jhh.2013.32
PG 8
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 235UC
UT WOS:000325745200004
PM 23698004
DA 2025-06-11
ER

PT J
AU Zadeh, ZH
   Najdegerami, EH
   Niko, M
   Nejati, V
   Gavlighi, HA
AF Zadeh, Zahra Hossein
   Najdegerami, Ebrahim H.
   Niko, Mehdi
   Nejati, Vahid
   Gavlighi, Hassan Ahmadi
TI Low-molecular weight oligosaccharides from gum tragacanth (Astragalus
   gossypinus) ameliorate nonalcoholic fatty liver disease (NAFLD) in
   Wistar male rats
SO FOOD SCIENCE & NUTRITION
LA English
DT Article
DE autophagy; fatty liver; glycemia; gum tragacanth; oligosaccharides;
   oxidative stress
ID BIOLOGICAL-ACTIVITIES; METABOLIC SYNDROME; OXIDATIVE STRESS; IN-VITRO;
   STEATOHEPATITIS; AUTOPHAGY; OBESITY; POLYSACCHARIDES; MICROBIOTA;
   INFLAMMATION
AB Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease affecting 25% of the world's population. The effects of oligosaccharides from Gum tragacanth (Astragalus gossypinus) (GT) on oxidative stress, glucose metabolism, and expression of autophagy genes were investigated in induced non-alcoholic fatty liver. Twenty-four male healthy rats were divided into four groups, Control; high-fat diet, high-fat diet+ 100mg GT oligosaccharides/kg body weight, high-fat diet + 200 mg GT oligosaccharides/kg body weight and fed with the trial diets for 70days. At the end of the experiment, the results indicated that GT oligosaccharides affected the weight gain and liver weight in NAFLD-induced rats. In addition, the results showed that the use of GT oligosaccharides significantly decreased oxidative stress, liver injury, and hyperglycemia (p<.05) and upregulated the expression of autophagy genes in NAFLD-induced rats.
C1 [Zadeh, Zahra Hossein; Najdegerami, Ebrahim H.; Nejati, Vahid] Urmia Univ, Dept Biol, Fac Sci, Orumiyeh, Iran.
   [Niko, Mehdi] Urmia Univ, Dept Pathobiol & Qual Control, Artemia & Aquaculture Res Inst, Orumiyeh, Iran.
   [Gavlighi, Hassan Ahmadi] Tarbiat Modares Univ, Dept Food Sci & Technol, Fac Agr, Tehran, Iran.
C3 Urmia University; Urmia University; Tarbiat Modares University
RP Najdegerami, EH (corresponding author), Urmia Univ, Dept Biol, Fac Sci, Orumiyeh, Iran.
EM e.geraini@urmia.ac.ir
RI Nikoo, Mehdi/AAU-4566-2020; Ahmadi Gavlighi, Hassan/E-2368-2011
OI Ahmadi Gavlighi, Hassan/0000-0001-9103-2291; Nikoo,
   Mehdi/0000-0001-7928-9588
FU Urmia University [4542]
FX Urmia University, Grant/Award Number: 4542
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NR 62
TC 6
Z9 6
U1 1
U2 21
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2048-7177
J9 FOOD SCI NUTR
JI Food Sci. Nutr.
PD FEB
PY 2023
VL 11
IS 2
BP 765
EP 777
DI 10.1002/fsn3.3112
EA OCT 2022
PG 13
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA 8Y4YY
UT WOS:000870685100001
PM 36789034
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Yisireyili, M
   Hayashi, M
   Wu, HX
   Uchida, Y
   Yamamoto, K
   Kikuchi, R
   Hamrah, MS
   Nakayama, T
   Cheng, XW
   Matsushita, T
   Nakamura, S
   Niwa, T
   Murohara, T
   Takeshita, K
AF Yisireyili, Maimaiti
   Hayashi, Motoharu
   Wu, Hongxian
   Uchida, Yasuhiro
   Yamamoto, Koji
   Kikuchi, Ryosuke
   Hamrah, Mohammad Shoaib
   Nakayama, Takayuki
   Cheng, Xian Wu
   Matsushita, Tadashi
   Nakamura, Shigeo
   Niwa, Toshimitsu
   Murohara, Toyoaki
   Takeshita, Kyosuke
TI Xanthine oxidase inhibition by febuxostat attenuates stress-induced
   hyperuricemia, glucose dysmetabolism, and prothrombotic state in mice
SO SCIENTIFIC REPORTS
LA English
DT Article
ID SERUM URIC-ACID; INSULIN-RESISTANCE; OXIDATIVE STRESS; ADIPOSE-TISSUE;
   OXIDOREDUCTASE; INFLAMMATION; GENE; ATHEROSCLEROSIS; DISEASE; CELLS
AB Chronic stress is closely linked to the metabolic syndrome, diabetes, hyperuricemia and thromboembolism, but the mechanisms remain elusive. We reported recently that stress targets visceral adipose tissue (VAT), inducing lipolysis, low-grade inflammation with production of inflammatory adipokines, metabolic derangements such as insulin resistance, and prothrombotic state. In the present study, we hypothesized the involvement of VAT xanthine oxidoreductase (XOR), a source of reactive oxygen species (ROS) and uric acid (UA) in the above processes. Restraint stress in mice resulted in upregulation of XOR and xanthine oxidase activity, accumulation of ROS in VAT as well as liver and intestine, increase in serum UA levels, upregulation of NADPH oxidase subunits and downregulation of antioxidant enzymes. Immunohistochemistry and RT-PCR analysis also showed that restraint stress induced VAT monocyte accumulation and proinflammatory adipokine production, resulting in reduced insulin sensitivity and induction of plasminogen activator inhibitor-1 and tissue factor in VAT. Treatment with febuxostat, a potent XO inhibitor, suppressed stress-induced ROS production and VAT inflammation, resulting in improvement of serum UA levels, insulin sensitivity, and prothrombotic tendency. Our results suggest that stress perturbs glucose and UA metabolism, and promotes prothrombotic status, and that XO inhibition by febuxostat might be a potential therapy for stress-related disorders.
C1 [Yisireyili, Maimaiti; Hayashi, Motoharu; Wu, Hongxian; Uchida, Yasuhiro; Hamrah, Mohammad Shoaib; Cheng, Xian Wu; Murohara, Toyoaki; Takeshita, Kyosuke] Nagoya Univ, Grad Sch Med, Dept Cardiol, Nagoya, Aichi, Japan.
   [Kikuchi, Ryosuke; Matsushita, Tadashi; Takeshita, Kyosuke] Nagoya Univ Hosp, Dept Clin Lab, Nagoya, Aichi, Japan.
   [Yamamoto, Koji; Matsushita, Tadashi] Nagoya Univ Hosp, Dept Blood Transfus, Nagoya, Aichi, Japan.
   [Nakamura, Shigeo] Nagoya Univ Hosp, Dept Pathol, Nagoya, Aichi, Japan.
   [Nakayama, Takayuki] Aichi Med Univ Hosp, Dept Blood Transfus, Nagakute, Aichi, Japan.
   [Wu, Hongxian] Shanghai Jiao Tong Univ, Shanghai Gen Hosp, Dept Cardiol, Sch Med, Shanghai, Peoples R China.
   [Niwa, Toshimitsu] Shubun Univ, Fac Hlth & Nutr, Ichinomiya, Aichi, Japan.
C3 Nagoya University; Nagoya University; Nagoya University; Nagoya
   University; Aichi Medical University; Shanghai Jiao Tong University
RP Takeshita, K (corresponding author), Nagoya Univ, Grad Sch Med, Dept Cardiol, Nagoya, Aichi, Japan.; Takeshita, K (corresponding author), Nagoya Univ Hosp, Dept Clin Lab, Nagoya, Aichi, Japan.
EM kyousuke@med.nagoya-u.ac.jp
RI Kikuchi, Ryosuke/AAX-4971-2021; Takeshita, Kyosuke/AAD-9515-2020;
   Takeshita, Kyosuke/B-7008-2012
OI Nakayama, Takayuki/0000-0003-2389-2542; Hamrah, Mohammad
   Shoaib/0000-0003-1758-8341; Takeshita, Kyosuke/0000-0002-8283-3799
FU JSPS KAKENHI [15J00397]; Kakenhi [16K15411]; Grants-in-Aid for
   Scientific Research [15J00397, 16K15411] Funding Source: KAKEN
FX We thank Dr. F.G. Issa (www.word-medex.com.au) for the careful reading
   and editing of the manuscript. Work led by K.T. is supported by a
   Grant-in-Aid for Scientific Research (Kakenhi 16K15411). M.Y. is a JSPS
   doctoral fellow overseas researcher (JSPS KAKENHI Grant Number
   15J00397).
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NR 38
TC 52
Z9 62
U1 0
U2 21
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD APR 28
PY 2017
VL 7
AR 1266
DI 10.1038/s41598-017-01366-3
PG 15
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA ET4KA
UT WOS:000400247600025
PM 28455534
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Ma, ZQ
   Xin, ZL
   Di, WC
   Yan, XL
   Li, XF
   Reiter, RJ
   Yang, Y
AF Ma, Zhiqiang
   Xin, Zhenlong
   Di, Wencheng
   Yan, Xiaolong
   Li, Xiaofei
   Reiter, Russel J.
   Yang, Yang
TI Melatonin and mitochondrial function during ischemia/reperfusion injury
SO CELLULAR AND MOLECULAR LIFE SCIENCES
LA English
DT Review
DE Melatonin; Mitochondria; Ischemia/reperfusion injury; Oxidative stress
ID ISCHEMIA-REPERFUSION INJURY; ENDOPLASMIC-RETICULUM STRESS; PERMEABILITY
   TRANSITION PORE; MESENCHYMAL STEM-CELLS; OXIDATIVE STRESS;
   EXPERIMENTAL-MODELS; NITROSATIVE STRESS; METABOLIC SYNDROME;
   DIABETIC-RATS; BRAIN-INJURY
AB Ischemia/reperfusion (IR) injury occurs in many organs and tissues, and contributes to morbidity and mortality worldwide. Melatonin, an endogenously produced indolamine, provides a strong defense against IR injury. Mitochondrion, an organelle for ATP production and a decider for cell fate, has been validated to be a crucial target for melatonin to exert its protection against IR injury. In this review, we first clarify the mechanisms underlying mitochondrial dysfunction during IR and melatonin's protection of mitochondria under this condition. Thereafter, special focus is placed on the protective actions of melatonin against IR injury in brain, heart, liver, and others. Finally, we explore several potential future directions of research in this area. Collectively, the information compiled here will serve as a comprehensive reference for the actions of melatonin in IR injury identified to date and will hopefully aid in the design of future research and increase the potential of melatonin as a therapeutic agent.
C1 [Ma, Zhiqiang; Reiter, Russel J.; Yang, Yang] Northwest Univ, Fac Life Sci, Minist Educ, Key Lab Resource Biol & Biotechnol Western China, 229 Taibai North Rd, Xian 710069, Shaanxi, Peoples R China.
   [Ma, Zhiqiang; Yan, Xiaolong; Li, Xiaofei] Fourth Mil Med Univ, Tangdu Hosp, Dept Thorac Surg, 1 Xinsi Rd, Xian 710038, Shaanxi, Peoples R China.
   [Xin, Zhenlong; Yang, Yang] Fourth Mil Med Univ, Dept Biomed Engn, 169 Changle West Rd, Xian 710032, Shaanxi, Peoples R China.
   [Di, Wencheng] Nanjing Univ, Med Sch, Affiliated Drum Tower Hosp, Dept Cardiol, 321 Zhongshan Rd, Nanjing 210008, Jiangsu, Peoples R China.
   [Reiter, Russel J.; Yang, Yang] UT Hlth Sci Ctr, Dept Cellular & Struct Biol, 7703 Floyd Curl Dr, San Antonio, TX 78229 USA.
C3 Northwest University Xi'an; Ministry of Education - China; Air Force
   Medical University; Air Force Medical University; Nanjing University;
   University of Texas System; University of Texas Health Science Center at
   San Antonio
RP Yang, Y (corresponding author), Northwest Univ, Fac Life Sci, Minist Educ, Key Lab Resource Biol & Biotechnol Western China, 229 Taibai North Rd, Xian 710069, Shaanxi, Peoples R China.; Yang, Y (corresponding author), Fourth Mil Med Univ, Dept Biomed Engn, 169 Changle West Rd, Xian 710032, Shaanxi, Peoples R China.; Reiter, RJ (corresponding author), UT Hlth Sci Ctr, Dept Cellular & Struct Biol, 7703 Floyd Curl Dr, San Antonio, TX 78229 USA.
EM reiter@uthscsa.edu; yang200214yy@163.com
RI Ma, qiang/HZK-3874-2023; Li, xiaofei/GXF-7187-2022; Reiter,
   Russel/D-3221-2009
OI Ma, Zhiqiang/0000-0002-5555-2764; Yan, Xiaolong/0000-0003-2419-9707
FU National Natural Science Foundation of China [81500263]; China
   Postdoctoral Science Foundation [2016T90973, 2015M572681]
FX This work was supported by the National Natural Science Foundation of
   China (81500263) and China Postdoctoral Science Foundation (2016T90973
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NR 116
TC 93
Z9 100
U1 1
U2 29
PU SPRINGER BASEL AG
PI BASEL
PA PICASSOPLATZ 4, BASEL, 4052, SWITZERLAND
SN 1420-682X
EI 1420-9071
J9 CELL MOL LIFE SCI
JI Cell. Mol. Life Sci.
PD NOV
PY 2017
VL 74
IS 21
BP 3989
EP 3998
DI 10.1007/s00018-017-2618-6
PG 10
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA FJ5AB
UT WOS:000412754800009
PM 28795196
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Hur, KY
   Lee, MS
AF Hur, Kyu Yeon
   Lee, Myung-Shik
TI New mechanisms of metformin action: Focusing on mitochondria and the gut
SO JOURNAL OF DIABETES INVESTIGATION
LA English
DT Review
DE Autophagy; Gut; Mitochondria
ID THIOREDOXIN-INTERACTING PROTEIN; GLUCAGON-LIKE PEPTIDE-1; PANCREATIC
   BETA-CELLS; DIET-INDUCED OBESITY; GLUCOSE-HOMEOSTASIS; NLRP3
   INFLAMMASOME; OXIDATIVE STRESS; ER STRESS; INSULIN-RESISTANCE; C.
   ELEGANS
AB The most well-known mechanism of metformin action, one of the most commonly prescribed antidiabetic drugs, is adenosine monophosphate-activated protein kinase activation; however, recent investigations have shown that adenosine monophosphate-activated protein kinase-independent pathways can explain some of metformin's beneficial metabolic effects as well as undesirable side-effects. Such novel pathways include induction of mitochondrial stress, inhibition of mitochondrial shuttles, alteration of intestinal microbiota, suppression of glucagon signaling, activation of autophagy, attenuation of inflammasome activation, induction of incretin receptors and reduction of terminal endoplasmic reticulum stress. Together, these studies have broadened our understanding of the mechanisms of antidiabetic agents as well as the pathogenic mechanism of diabetes itself. The results of such investigations might help to identify new target molecules and pathways for treatment of diabetes and metabolic syndrome, and could also have broad implications in diseases other than diabetes. Accordingly, new antidiabetic drugs with better efficacy and fewer adverse effects will likely result from these studies.
C1 [Hur, Kyu Yeon; Lee, Myung-Shik] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Div Endocrinol & Metab,Dept Med, Seoul, South Korea.
C3 Sungkyunkwan University (SKKU); Samsung Medical Center
RP Lee, MS (corresponding author), Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Div Endocrinol & Metab,Dept Med, Seoul, South Korea.
EM mslee0923@skku.edu
RI Lee, Myung/C-9606-2011
FU Global Research Laboratory Grant of the National Research Foundation of
   Korea [K21004000003-10A0500-00310]; Ulsan National Institute of Science
   and Technology (UNIST) [2014M3A9D8034459]
FX This work was supported by the Global Research Laboratory Grant of the
   National Research Foundation of Korea (K21004000003-10A0500-00310), and
   the Ulsan National Institute of Science and Technology (UNIST) research
   fund (2014M3A9D8034459). The authors thank Sungkab Kim (Samsung Medical
   Center, Multimedia Services Part, Chief Illustrator) for illustrating
   the figures.
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PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2040-1124
J9 J DIABETES INVEST
JI J. Diabetes Investig.
PD NOV
PY 2015
VL 6
IS 6
BP 600
EP 609
DI 10.1111/jdi.12328
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA CU7AL
UT WOS:000363687000002
PM 26543531
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Lee, TY
   Chang, HH
   Lo, WC
   Lin, HC
AF Lee, Tzung-Yan
   Chang, Hen-Hong
   Lo, Wen-Chai
   Lin, Han-Chieh
TI Alleviation of hepatic oxidative stress by Chinese herbal medicine
   Yin-Chen-Hao-Tang in obese mice with steatosis
SO INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
LA English
DT Article
DE oxidative stress; herbal medicine; steatosis
ID FATTY-ACID OXIDATION; INCHIN-KO-TO; INSULIN-RESISTANCE; LIVER-DISEASE;
   METABOLIC SYNDROME; ADIPOSE-TISSUE; RATS; APOPTOSIS; FIBROSIS; PROTEIN
AB Obesity is associated with a complex systemic inflammatory state that has been implicated in the development of hepatic steatosis. This study was to test the efficacy of Yin-Chen-Hao-Tang (YCHT), an agent that improves hepatic triglyceride metabolism in its ability to modulate pathways implicated in hepatic steatosis. Mice were fed with high-fat diet for fifteen weeks. The therapeutic mechanism of YCHT likely enhanced adiponectin and endothelial progenitor cells, and up-regulation of peroxisome proliferator-activated receptor gamma might be responsible for fatty liver diseases. In addition, YCHT anti-oxidative stress effect might be associated with inhibition of hepatic free fatty acid concentrations and elevation of the glutathione levels in hepatic tissues. Furthermore, YCHT action mechanisms might promote senescence marker protein-30 metabolism that increase resistance to hepatic oxidative stress. These findings suggest a novel therapeutic approach for fatty liver progression in obesity mice.
C1 [Lee, Tzung-Yan; Chang, Hen-Hong; Lo, Wen-Chai] Chang Gung Univ, Grad Inst Tradit Chinese Med, Tao Yuan 333, Taiwan.
   [Chang, Hen-Hong] Chang Gung Mem Hosp, Ctr Tradit Chinese Med, Tao Yuan, Taiwan.
   [Lin, Han-Chieh] Taipei Vet Gen Hosp, Dept Med, Div Gastroenterol, Taipei, Taiwan.
C3 Chang Gung University; Chang Gung Memorial Hospital; Taipei Veterans
   General Hospital
RP Lee, TY (corresponding author), Chang Gung Univ, Grad Inst Tradit Chinese Med, 259 Wen Hwa 1st Rd, Tao Yuan 333, Taiwan.
EM joyamen@mail.cgu.edu.tw
RI Hen Hong, Chang/ITT-2813-2023; Lin, Han/GRF-1081-2022
OI Chang, Hen-Hong/0000-0002-7840-1504
FU National Science Council, Taipei, Taiwan [NSC96-2320-B-182-021]; Chang
   Gung Memorial Hospital [CMRPD180241]
FX This work was supported by the National Science Council, Taipei, Taiwan,
   NSC96-2320-B-182-021 and CMRPD180241 supported by a Research Grant from
   the Chang Gung Memorial Hospital.
CR Angulo P, 2002, NEW ENGL J MED, V346, P1221, DOI 10.1038/nrdp.2015.80
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NR 28
TC 40
Z9 41
U1 1
U2 20
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1107-3756
J9 INT J MOL MED
JI Int. J. Mol. Med.
PD JUN
PY 2010
VL 25
IS 6
BP 837
EP 844
DI 10.3892/ijmm_00000412
PG 8
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 594QB
UT WOS:000277551200002
PM 20428786
OA Bronze
DA 2025-06-11
ER

PT J
AU Alkazemi, D
   Jackson, RL
   Chan, HM
   Kubow, S
AF Alkazemi, Dalal
   Jackson, Robert L., II
   Chan, Hing Man
   Kubow, Stan
TI Increased F3-Isoprostanes in the Canadian Inuit Population
   Could Be Cardioprotective by Limiting F2-Isoprostane
   Production
SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Article
ID N-3 FATTY-ACIDS; FISH-OIL; OXIDATIVE STRESS; IN-VIVO;
   CARDIOVASCULAR-DISEASE; EICOSAPENTAENOIC ACID; DOCOSAHEXAENOIC ACID;
   BIOLOGICAL-FLUIDS; OXIDANT STRESS; HEALTH SURVEY
AB Context: F-3-isoprostanes (F-3-IsoPs), derived from peroxidation of eicosapentaenoic acid (C20:5n-3), could be cardioprotective by limiting production of F-2-isoprostanes (F-2-IsoPs), a cardiovascular disease risk factor.
   Objective: The objective of the study was to determine whether the n-3-polyunsaturated (PUFA)-rich Inuit diet is associated with a lower plasma ratio of F-2-IsoPs to F-3-IsoPs.
   Design: This was a cross-sectional observational study.
   Setting: The study was conducted in 36 Canadian Arctic Inuit communities.
   Participants: Participants included a random subset (n = 233) of Inuit adults taken from a population-based survey.
   Main Outcome Measures: Plasma F-2-IsoPs and F-3-IsoPs, cardiometabolic risk factors (blood lipids, C-reactive protein, blood pressure, fasting glucose) and markers of dietary exposure (erythrocyte n-3 and n-6 PUFA, blood levels of Se, mercury, polychlorinated biphenyls) were measured.
   Results: Inuit aged 40 years old and older vs younger Inuit showed higher concentrations of plasma F-3-IsoPs and erythrocyte n-3 PUFA and lower plasma F-2-IsoPs concentrations despite having higher blood lipids, fasting glucose, systolic blood pressure, and percentage body fat. Plasma F-3-IsoPs were not associated with any cardiometabolic measures. When subjects were categorized into tertiles according to total n-3 PUFA erythrocyte concentrations, F-3-IsoPs increased with increasing tertiles, whereas the F-2-IsoP to F-3-IsoP ratio was lowest at the highest n-3 tertile. The F-2-IsoP to F-3-IsoP ratio was significantly predicted by C20:5n-3 (beta = -.365, P = .002); C20:4n-6:C20:5n-3 (beta = .056, P = .006), blood mercury (beta = -.812, P = .015), blood Se (beta = -1.95, P = .015), and smoking (beta = .745, P = .025).
   Conclusions: Plasma F-3-IsoPs were not associated with cardiometabolic risk factors previously seen with F-2-IsoPs. Higher n-3 fatty acid status was associated with lower plasma F-2-IsoPs and higher plasma F-3-IsoPs, which provides partial explanation to the cardioprotective effects of the n-3 PUFA-rich Inuit diet.
C1 [Alkazemi, Dalal; Kubow, Stan] McGill Univ, Sch Dietet & Human Nutr, 21 111 Lakeshore, Ste Anne De Bellevue, PQ H9X 3V9, Canada.
   [Alkazemi, Dalal] McGill Univ, Ctr Indigenous Peoples Nutr & Environm, 21 111 Lakeshore, Ste Anne De Bellevue, PQ H9X 3V9, Canada.
   [Alkazemi, Dalal] Kuwait Univ, Coll Life Sci, Dept Food Sci & Nutr, Safat 13060, Kuwait.
   [Jackson, Robert L., II] Vanderbilt Univ, Dept Med & Pharmacol, Nashville, TN 37232 USA.
   [Chan, Hing Man] Univ Ottawa, Ctr Adv Res Environm Genom, Ottawa, ON K1N 6N5, Canada.
C3 McGill University; McGill University; Kuwait University; Vanderbilt
   University; University of Ottawa
RP Kubow, S (corresponding author), McGill Univ, Sch Dietet & Human Nutr, 21 111 Lakeshore, Ste Anne De Bellevue, PQ H9X 3V9, Canada.
EM stan.kubow@mcgill.ca
RI Jackson, Robert/U-1061-2019; Chan, Laurie/C-4055-2014; Kubow,
   Stan/AAJ-6913-2021; Alkazemi, Dalal Usamah Zaid/E-5481-2018
OI Alkazemi, Dalal Usamah Zaid/0000-0001-9349-2144; Kubow,
   Stan/0000-0001-5831-9880; Chan, Laurie/0000-0003-4351-7483
FU Government of Canada Federal Program for International Polar Year;
   Canadian Institutes of Health Research; Canadian Foundation for
   Innovation; Canada Research Chair Program; Health Canada; Aboriginal
   Affairs, and Northern Development Canada; Government of Nunavut;
   University of Toronto; Arctic Net
FX This work was based on support by the Government of Canada Federal
   Program for International Polar Year, Canadian Institutes of Health
   Research, Canadian Foundation for Innovation, Canada Research Chair
   Program, Health Canada, Aboriginal Affairs, and Northern Development
   Canada, Government of Nunavut, University of Toronto, and Arctic Net.
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NR 33
TC 6
Z9 7
U1 0
U2 6
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0021-972X
EI 1945-7197
J9 J CLIN ENDOCR METAB
JI J. Clin. Endocrinol. Metab.
PD SEP
PY 2016
VL 101
IS 9
BP 3264
EP 3271
DI 10.1210/jc.2015-4096
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA EG2CB
UT WOS:000390849100009
PM 27192695
OA Bronze
DA 2025-06-11
ER

PT J
AU Juratli, SM
   Janisse, J
   Schwartz, K
   Arnetz, BB
AF Juratli, Sham Maghout
   Janisse, James
   Schwartz, Kendra
   Arnetz, Bengt B.
TI Demographic and lifestyle factors associated with perceived stress in
   the primary care setting: a MetroNet study
SO FAMILY PRACTICE
LA English
DT Article
DE Family medicine; stress
ID SELF-RATED HEALTH; CHRONIC-FATIGUE-SYNDROME; MIDDLE-AGED MEN;
   SOCIOECONOMIC-STATUS; SOCIAL SUPPORT; PSYCHOLOGICAL DISTRESS; METABOLIC
   SYNDROME; WOMEN; SLEEP; NEIGHBORHOOD
AB Methods. We distributed surveys to 100 consecutive adult patients in each of four family medicine centres in metropolitan Detroit between 2006 and 2007. Hierarchical multivariable regression analyses were used to assess the relative significance of the demographic and lifestyle factors related to stress.
   Results. Of the 400 distributed surveys, 315 (78.7%) answered a minimum of 70% of the questions and were included in the analysis. The lifestyle factors [exercise, body mass index (BMI), sleep, social support, recovery or self-care skills (such as the ability to rest, relax and recuperate)] explained 39% (P < 0.001) of the variance in stress compared to 10% (P < 0.001) by the demographic factors (age, gender, race, employment, education and marital status). Stress was inversely related to sleep (P < 0.001), recovery (P < 0.001) and social support (P = 0.02) and positively to education (P < 0.001).
   Conclusions. The modifiable lifestyle factors explained significantly more of perceived stress among primary care patients than the demographic factors. Sleep and recovery had the biggest inverse relationship with stress, which suggests that they should be the primary target for assessment and intervention in patients who report stress or stress-related disorders.
C1 [Juratli, Sham Maghout; Janisse, James; Schwartz, Kendra; Arnetz, Bengt B.] Wayne State Univ, Dept Family Med & Publ Hlth Sci, Detroit, MI 48201 USA.
C3 Wayne State University
RP Juratli, SM (corresponding author), Wayne State Univ, Dept Family Med & Publ Hlth Sci, 3939 Woodward Ave, Detroit, MI 48201 USA.
EM smjuratli@med.wayne.edu
RI Arnetz, Bengt/G-1685-2011
FU Wayne State University; Skandia insurance [420393]
FX Wayne State University research start up funds and Skandia insurance, a
   member of the Old Mutual Group (420393).
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NR 48
TC 9
Z9 10
U1 0
U2 7
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0263-2136
EI 1460-2229
J9 FAM PRACT
JI Fam. Pr.
PD APR
PY 2011
VL 28
IS 2
BP 156
EP 162
DI 10.1093/fampra/cmq091
PG 7
WC Primary Health Care; Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA 740MN
UT WOS:000288798900006
PM 21068192
DA 2025-06-11
ER

PT J
AU Zheng, YJ
   Zhu, DM
AF Zheng, Yijun
   Zhu, Duming
TI Molecular Hydrogen Therapy Ameliorates Organ Damage Induced by Sepsis
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Review
ID OXIDATIVE STRESS; POLYMICROBIAL SEPSIS; COMBINATION THERAPY; FLUID
   RESUSCITATION; CECAL LIGATION; MURINE MODEL; INJURY; LUNG; MICE;
   INHALATION
AB Since it was proposed in 2007, molecular hydrogen therapy has been widely concerned and researched. Many animal experiments were carried out in a variety of disease fields, such as cerebral infarction, ischemia reperfusion injury, Parkinson syndrome, type 2 diabetes mellitus, metabolic syndrome, chronic kidney disease, radiation injury, chronic hepatitis, rheumatoid arthritis, stress ulcer, acute sports injuries, mitochondrial and inflammatory disease, and acute erythema skin disease and other pathological processes or diseases. Molecular hydrogen therapy is pointed out as there is protective effect for sepsis patients, too. The impact of molecular hydrogen therapy against sepsis is shown from the aspects of basic vital signs, organ functions (brain, lung, liver, kidney, small intestine, etc.), survival rate, and so forth. Molecular hydrogen therapy is able to significantly reduce the release of inflammatory factors and oxidative stress injury. Thereby it can reduce damage of various organ functions from sepsis and improve survival rate. Molecular hydrogen therapy is a prospective method against sepsis.
C1 [Zheng, Yijun; Zhu, Duming] Fudan Univ, Zhongshan Hosp, Dept Crit Care Med, Shanghai 200032, Peoples R China.
C3 Fudan University
RP Zhu, DM (corresponding author), Fudan Univ, Zhongshan Hosp, Dept Crit Care Med, Shanghai 200032, Peoples R China.
EM zhu.duming@zs-hospital.sh.cn
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NR 16
TC 22
Z9 27
U1 1
U2 12
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PY 2016
VL 2016
AR 5806057
DI 10.1155/2016/5806057
PG 6
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA DQ2VY
UT WOS:000379062800001
PM 27413421
OA Green Submitted, Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Bradford, BJ
   Contreras, GA
AF Bradford, Barry J.
   Contreras, G. Andres
TI Adipose Tissue Inflammation: Linking Physiological Stressors to Disease
   Susceptibility
SO ANNUAL REVIEW OF ANIMAL BIOSCIENCES
LA English
DT Review
DE immunity; metabolism; homeostasis; programming; inflammation;
   endocrinology
ID REGULATORY T-CELLS; BODY-WEIGHT LOSS; DAIRY-COWS; HEAT-STRESS;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; FETAL; FAT; MACROPHAGES;
   METABOLISM
AB The study of adipose tissue (AT) is enjoying a renaissance. White, brown, and beige adipocytes are being investigated in adult animals, and the critical roles of small depots like perivascular AT are becoming clear. But the most profound revision of the AT dogma has been its cellular composition and regulation. Single-cell transcriptomic studies revealed that adipocytes comprise well under 50% of the cells in white AT, and a substantial portion of the rest are immune cells. Altering the function of AT resident leukocytes can induce or correct metabolic syndrome and, more surprisingly, alter adaptive immune responses to infection. Although the field is dominated by obesity research, conditions such as rapid lipolysis, infection, and heat stress impact AT immune dynamics as well. Recent findings in rodents lead to critical questions that should be explored in domestic livestock as potential avenues for improved animal resilience to stressors, particularly as animals age.
C1 [Bradford, Barry J.] Michigan State Univ, Dept Anim Sci, Coll Agr & Nat Resources, E Lansing, MI 48824 USA.
   [Contreras, G. Andres] Michigan State Univ, Dept Large Anim Clin Sci, Coll Vet Med, E Lansing, MI USA.
C3 Michigan State University; Michigan State University
RP Bradford, BJ (corresponding author), Michigan State Univ, Dept Anim Sci, Coll Agr & Nat Resources, E Lansing, MI 48824 USA.
EM bjbrad@msu.edu; contre28@msu.edu
RI Bradford, Barry/B-7870-2010; Contreras, G. Andres/C-7621-2012
OI Contreras, G. Andres/0000-0003-4969-2178
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NR 138
TC 10
Z9 11
U1 2
U2 4
PU ANNUAL REVIEWS
PI PALO ALTO
PA 4139 EL CAMINO WAY, PO BOX 10139, PALO ALTO, CA 94303-0139 USA
SN 2165-8102
EI 2165-8110
J9 ANNU REV ANIM BIOSCI
JI Annu. Rev. Anim. Biosci.
PY 2024
VL 12
BP 261
EP 281
DI 10.1146/annurev-animal-021122-113212
PG 21
WC Agriculture, Dairy & Animal Science; Biotechnology & Applied
   Microbiology; Veterinary Sciences; Zoology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture; Biotechnology & Applied Microbiology; Veterinary Sciences;
   Zoology
GA MJ6O5
UT WOS:001193295300013
PM 38064480
OA hybrid
DA 2025-06-11
ER

PT J
AU Ramos, VP
   da Silva, PG
   Oliveira, PS
   Bona, NP
   Soares, MSP
   Cardoso, JD
   Hoffmann, JF
   Chaves, FC
   Schneider, A
   Spanevello, RM
   Lencina, CL
   Stefanello, FM
   Tavares, RG
AF Ramos, Vanessa Plasse
   da Silva, Pamela Goncalves
   Oliveira, Pathise Souto
   Bona, Natalia Pontes
   Pereira Soares, Mayara Sandrielly
   Cardoso, Juliane de Souza
   Hoffmann, Jessica Fernanda
   Chaves, Fabio Clasen
   Schneider, Augusto
   Spanevello, Roselia Maria
   Lencina, Claiton Leoneti
   Stefanello, Francieli Moro
   Tavares, Rejane Giacomelli
TI Hypolipidemic and anti-inflammatory properties of phenolic richButia
   odoratafruit extract: potential involvement of paraoxonase activity
SO BIOMARKERS
LA English
DT Article
DE Phenolic compounds; animal model system; cardiovascular disease
ID OXIDATIVE STRESS; LIPOPROTEIN-LIPASE; METABOLIC SYNDROME; SEED EXTRACT;
   HYPERLIPIDEMIA; ACID; BUTYRYLCHOLINESTERASE; EXPRESSION;
   ATHEROSCLEROSIS; LYMPHOCYTES
AB Aim:This study investigated the effects of polarButia odoratafruit extract on metabolic, inflammatory, and oxidative stress parameters in rats submitted to a hyperlipidaemia condition induced by tyloxapol. Methods:Animals were divided into 3 groups: saline, saline plus tyloxapol, andB. odorataextract plus tyloxapol. Animals were treated for 15 days with a saline solution orB. odoratafruit extract and after hyperlipidaemia was induced by tyloxapol. Results:Treatment withB. odorataextract reduced serum triglyceride, total cholesterol, C-reactive protein, and adenosine deaminase and butyrylcholinesterase activities when compared to the tyloxapol group. HDL-cholesterol and paraoxonase 1 activity were higher inB. odorataextract treated animals when compared to tyloxapol-treated animals. No differences were observed in hepatic oxidative stress parameters. Phenolic compounds present inB. odoratafruit extract were identified and quantified by LC-MS/MS. Conclusion:These findings indicated that phenolic richB. odorataextract has hypolipidemic and anti-inflammatory effects in hyperlipidemic rats.
C1 [Ramos, Vanessa Plasse; da Silva, Pamela Goncalves; Oliveira, Pathise Souto; Bona, Natalia Pontes; Cardoso, Juliane de Souza; Lencina, Claiton Leoneti; Stefanello, Francieli Moro; Tavares, Rejane Giacomelli] Univ Fed Pelotas, Ctr Ciencias Quim Farmaceut & Alimentos, Lab Biomarcadores, Campus Univ S-N, BR-96160000 Pelotas, RS, Brazil.
   [Pereira Soares, Mayara Sandrielly; Spanevello, Roselia Maria] Univ Fed Pelotas, Ctr Ciencias Quim Farmaceut & Alimentos, Lab Neuroquim Inflamacao & Canc, Pelotas, RS, Brazil.
   [Hoffmann, Jessica Fernanda; Chaves, Fabio Clasen] Univ Fed Pelotas, Dept Ciencia & Tecnol Agroind, Programa Posgrad Ciencia & Tecnol Alimentos, Pelotas, RS, Brazil.
   [Schneider, Augusto] Univ Fed Pelotas, Fac Nutr, Pelotas, RS, Brazil.
C3 Universidade Federal de Pelotas; Universidade Federal de Pelotas;
   Universidade Federal de Pelotas; Universidade Federal de Pelotas
RP Stefanello, FM (corresponding author), Univ Fed Pelotas, Ctr Ciencias Quim Farmaceut & Alimentos, Lab Biomarcadores, Campus Univ S-N, BR-96160000 Pelotas, RS, Brazil.
EM nessaplasse@hotmail.com; fmstefanello@gmail.com;
   tavares.rejane@gmail.com
RI Tavares, Rejane/C-1307-2010; Spanevello, Roselia/H-1610-2018; Hoffmann,
   Jessica/E-2239-2017; de Aguiar, Mayara Sandrielly/ABA-5461-2021;
   Schneider, Augusto/B-5011-2014; Chaves, Fabio/A-6390-2013
OI Schneider, Augusto/0000-0002-3410-2860; Spanevello,
   Roselia/0000-0002-5117-2000; Giacomelli Tavares,
   Rejane/0000-0002-9806-1893; Chaves, Fabio/0000-0002-5773-0800
FU SDECT-RS
FX To the research funding agencies SDECT-RS, FAPERGS, CAPES, and CNPQ (FCC
   - 457947/2014-4).
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NR 61
TC 4
Z9 4
U1 1
U2 9
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1354-750X
EI 1366-5804
J9 BIOMARKERS
JI Biomarkers
PD JUL 3
PY 2020
VL 25
IS 5
BP 417
EP 424
DI 10.1080/1354750X.2020.1781261
PG 8
WC Biotechnology & Applied Microbiology; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Toxicology
GA MG1SN
UT WOS:000545812700008
PM 32519899
DA 2025-06-11
ER

PT J
AU Sell, H
   Dietze-Schroeder, D
   Eckel, J
AF Sell, Henrike
   Dietze-Schroeder, Daniela
   Eckel, Juergen
TI The adipocyte-myocyte axis in insulin resistance
SO TRENDS IN ENDOCRINOLOGY AND METABOLISM
LA English
DT Review
ID HUMAN SKELETAL-MUSCLE; NECROSIS-FACTOR-ALPHA; KAPPA-B KINASE;
   ENDOPLASMIC-RETICULUM STRESS; WHITE ADIPOSE-TISSUE; FREE FATTY-ACIDS;
   METABOLIC SYNDROME; 3T3-L1 ADIPOCYTES; DIABETES-MELLITUS; POTENTIAL ROLE
AB Insulin resistance in skeletal muscle is linked to an elevated adipose tissue mass, as is found in obesity, but can also be observed in lipodystrophy, in which adipose tissue is greatly reduced. Adipose tissue releases endocrine and metabolic mediators and is actively involved in crosstalk with skeletal muscle, a process that precedes and underlies the development of insulin resistance in muscles. Adipokines including tumor necrosis factor alpha, interieukin-6, leptin and adiponectin influence insulin signaling in skeletal muscle. Free fatty acids, their metabolites and ectopic fat in muscle also contribute to insulin resistance. Recent research indicates inflammation, endoplasmic reticulum stress and oxidative stress could be underlying mechanisms at the center of the development of insulin resistance. Insights into the role of macrophages in adipose tissue add to the complicated interplay between adipose tissue and skeletal muscle.
C1 German Diabet Ctr, Inst Clin Biochem & Pathobiochem, Dusseldorf, Germany.
C3 Leibniz Association; Deutsches Diabetes-Zentrum (DDZ)
RP Eckel, J (corresponding author), German Diabet Ctr, Inst Clin Biochem & Pathobiochem, Dusseldorf, Germany.
EM eckel@uni-duesseldorf.de
OI Sell, Henrike/0000-0001-6323-6158; Eckel, Juergen/0000-0003-3645-5288
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NR 99
TC 94
Z9 113
U1 0
U2 16
PU ELSEVIER SCIENCE LONDON
PI LONDON
PA 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND
SN 1043-2760
EI 1879-3061
J9 TRENDS ENDOCRIN MET
JI Trends Endocrinol. Metab.
PD DEC
PY 2006
VL 17
IS 10
BP 416
EP 422
DI 10.1016/j.tem.2006.10.010
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 119ZY
UT WOS:000243054200013
PM 17084639
DA 2025-06-11
ER

PT J
AU Berger, S
   Polotsky, VY
AF Berger, Slava
   Polotsky, Vsevolod Y.
TI Leptin and Leptin Resistance in the Pathogenesis of Obstructive Sleep
   Apnea: A Possible Link to Oxidative Stress and Cardiovascular
   Complications
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Review
ID CHRONIC INTERMITTENT HYPOXIA; POSITIVE AIRWAY PRESSURE; DIET-INDUCED
   OBESITY; SYMPATHETIC-NERVOUS-SYSTEM; RECEPTOR MESSENGER-RNA; NADPH
   OXIDASE; INSULIN-RESISTANCE; METABOLIC SYNDROME; HEART-FAILURE;
   RISK-FACTOR
AB Obesity-related sleep breathing disorders such as obstructive sleep apnea (OSA) and obesity hypoventilation syndrome (OHS) cause intermittent hypoxia (IH) during sleep, a powerful trigger of oxidative stress. Obesity also leads to dramatic increases in circulating levels of leptin, a hormone produced in adipose tissue. Leptin acts in the hypothalamus to suppress food intake and increase metabolic rate. However, obese individuals are resistant to metabolic effects of leptin. Leptin also activates the sympathetic nervous system without any evidence of resistance, possibly because these effects occur peripherally without a need to penetrate the blood-brain barrier. IH is a potent stimulator of leptin expression and release from adipose tissue. Hyperleptinemia and leptin resistance may upregulate generation of reactive oxygen species, increasing oxidative stress and promoting inflammation. The current review summarizes recent data on a possible link between leptin and oxidative stress in the pathogenesis of sleep breathing disorders.
C1 [Berger, Slava; Polotsky, Vsevolod Y.] Johns Hopkins Univ, Sch Med, Dept Med, Div Pulm & Crit Care & Sleep Med, Baltimore, MD 21205 USA.
C3 Johns Hopkins University
RP Polotsky, VY (corresponding author), Johns Hopkins Univ, Sch Med, Dept Med, Div Pulm & Crit Care & Sleep Med, Baltimore, MD 21205 USA.
EM vpolots1@jhmi.edu
RI Berger, Slava/AAF-7088-2020
OI Polotsky, Vsevolod/0000-0002-2951-7535; Berger,
   Slava/0000-0001-6188-0118
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NR 106
TC 82
Z9 85
U1 0
U2 11
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PY 2018
VL 2018
AR 5137947
DI 10.1155/2018/5137947
PG 8
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA FX1SJ
UT WOS:000425831800001
PM 29675134
OA Green Submitted, hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Sztretye, M
   Dienes, B
   Gönczi, M
   Czirják, T
   Csernoch, L
   Dux, L
   Szentesi, P
   Keller-Pintér, A
AF Sztretye, Monika
   Dienes, Beatrix
   Gonczi, Monika
   Czirjak, Tamas
   Csernoch, Laszlo
   Dux, Laszlo
   Szentesi, Peter
   Keller-Pinter, Aniko
TI Astaxanthin: A Potential Mitochondrial-Targeted Antioxidant Treatment in
   Diseases and with Aging
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Review
ID INSULIN-RECEPTOR SUBSTRATE-1; INDUCED OXIDATIVE STRESS; DISUSE MUSCLE
   ATROPHY; SKELETAL-MUSCLE; LIPID-METABOLISM; UP-REGULATION; CAROTENOID
   ASTAXANTHIN; SARCOPLASMIC-RETICULUM; CAPILLARY REGRESSION;
   GLUCOSE-METABOLISM
AB Oxidative stress is characterized by an imbalance between prooxidant and antioxidant species, leading to macromolecular damage and disruption of redox signaling and cellular control. It is a hallmark of various diseases including metabolic syndrome, chronic fatigue syndrome, neurodegenerative, cardiovascular, inflammatory, and age-related diseases. Several mitochondrial defects have been considered to contribute to the development of oxidative stress and known as the major mediators of the aging process and subsequent age-associated diseases. Thus, mitochondrial-targeted antioxidants should prevent or slow down these processes and prolong longevity. This is the reason why antioxidant treatments are extensively studied and newer and newer compounds with such an effect appear. Astaxanthin, a xanthophyll carotenoid, is the most abundant carotenoid in marine organisms and is one of the most powerful natural compounds with remarkable antioxidant activity. Here, we summarize its antioxidant targets, effects, and benefits in diseases and with aging.
C1 [Sztretye, Monika; Dienes, Beatrix; Gonczi, Monika; Czirjak, Tamas; Csernoch, Laszlo; Szentesi, Peter] Univ Debrecen, Fac Med, Dept Physiol, H-4002 Debrecen, Hungary.
   [Dux, Laszlo; Keller-Pinter, Aniko] Univ Szeged, Fac Med, Dept Biochem, H-6720 Szeged, Hungary.
C3 University of Debrecen; Szeged University
RP Szentesi, P (corresponding author), Univ Debrecen, Fac Med, Dept Physiol, H-4002 Debrecen, Hungary.; Keller-Pintér, A (corresponding author), Univ Szeged, Fac Med, Dept Biochem, H-6720 Szeged, Hungary.
EM szentesi.peter@med.unideb.hu; keller.aniko@med.u-szeged.hu
RI Gonczi, Monika/ABD-1465-2021; Dux, László/B-6174-2012; Keller-Pinter,
   Aniko/A-9608-2013
OI Laszlo, Dux/0000-0002-1270-1678; Dienes, Beatrix/0000-0002-3110-0296;
   Szentesi, Peter/0000-0003-2621-2282; Csernoch,
   Laszlo/0000-0002-2446-1456; Sztretye, Monika/0000-0002-5946-6986;
   Keller-Pinter, Aniko/0000-0002-4105-8458; Gonczi,
   Monika/0000-0002-8421-4369
FU Hungarian National Research, Development and Innovation Office (Hungary)
   [NKFIH NK-115461, PD-128370, GINOP-2.3.2-15-2016-00040,
   EFOP-3.6.2-16-2017-00006]; Higher Education Institutional Excellence
   Programme of the Ministry of Human Capacities in Hungary of the
   University of Debrecen [20428-3/2018/FEKUTSTRAT]; Hungarian Academy of
   Sciences; New National Excellence Program of the Ministry for Innovation
   and Technology Sciences [UNKP-18-4-DE-157, UNKP-19-4-SZTE-23]
FX This work was supported by NKFIH NK-115461, PD-128370,
   GINOP-2.3.2-15-2016-00040, and EFOP-3.6.2-16-2017-00006 grants of the
   Hungarian National Research, Development and Innovation Office (Hungary)
   and was financed by the Higher Education Institutional Excellence
   Programme of the Ministry of Human Capacities in Hungary, within the
   framework of the 20428-3/2018/FEKUTSTRAT thematic programme of the
   University of Debrecen. Additional fundings are Janos Bolyai Research
   Scholarship of the Hungarian Academy of Sciences (to A. K.-P. and M.
   Sz.) and New National Excellence Program of the Ministry for Innovation
   and Technology Sciences (UNKP-18-4-DE-157 to M. Sz. and
   UNKP-19-4-SZTE-23 to A. K.-P.).
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NR 154
TC 142
Z9 149
U1 8
U2 51
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PD NOV 11
PY 2019
VL 2019
AR 3849692
DI 10.1155/2019/3849692
PG 14
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA JQ8AO
UT WOS:000499161600008
PM 31814873
OA Green Published, Green Accepted, hybrid
DA 2025-06-11
ER

PT J
AU O'Brien, PD
   Hinder, LM
   Sakowski, SA
   Feldman, EL
AF O'Brien, Phillipe D.
   Hinder, Lucy M.
   Sakowski, Stacey A.
   Feldman, Eva L.
TI ER Stress in Diabetic Peripheral Neuropathy: A New Therapeutic Target
SO ANTIOXIDANTS & REDOX SIGNALING
LA English
DT Review
ID ENDOPLASMIC-RETICULUM STRESS; UNFOLDED PROTEIN RESPONSE;
   GLUCOSE-REGULATED PROTEINS; DORSAL-ROOT GANGLION; INSULIN-RESISTANCE;
   OXIDATIVE STRESS; CALCIUM HOMEOSTASIS; CELL-SURVIVAL; CHEMICAL
   CHAPERONES; SENSORY NEURONS
AB Significance: Diabetes and other diseases that comprise the metabolic syndrome have reached epidemic proportions. Diabetic peripheral neuropathy (DPN) is the most prevalent complication of diabetes, affecting similar to 50% of diabetic patients. Characterized by chronic pain or loss of sensation, recurrent foot ulcerations, and risk for amputation, DPN is associated with significant morbidity and mortality. Mechanisms underlying DPN pathogenesis are complex and not well understood, and no effective treatments are available. Thus, an improved understanding of DPN pathogenesis is critical for the development of successful therapeutic options. Recent Advances: Recent research implicates endoplasmic reticulum (ER) stress as a novel mechanism in the onset and progression of DPN. ER stress activates the unfolded protein response (UPR), a well-orchestrated signaling cascade responsible for relieving stress and restoring normal ER function. Critical Issues: During times of extreme or chronic stress, such as that associated with diabetes, the UPR may be insufficient to alleviate ER stress, resulting in apoptosis. Here, we discuss the potential role of ER stress in DPN, as well as evidence demonstrating how ER stress intersects with pathways involved in DPN development and progression. An improved understanding of how ER stress contributes to peripheral nerve dysfunction in diabetes will provide important insight into DPN pathogenesis. Future Directions: Future studies aimed at gaining the necessary insight into ER stress in DPN pathogenesis will ultimately facilitate the development of novel therapies.
C1 [O'Brien, Phillipe D.; Hinder, Lucy M.; Feldman, Eva L.] Univ Michigan, Dept Neurol, Ann Arbor, MI 48109 USA.
   [Sakowski, Stacey A.] Univ Michigan, A Alfred Taubman Med Res Inst, Ann Arbor, MI 48109 USA.
C3 University of Michigan System; University of Michigan; University of
   Michigan System; University of Michigan
RP Feldman, EL (corresponding author), Univ Michigan, Dept Neurol, 109 Zina Pitcher Pl 5017 AAT BSRB, Ann Arbor, MI 48109 USA.
EM efeldman@umich.edu
RI O'Brien, Phillipe/W-4268-2019
OI O'Brien, Phillipe/0000-0002-6365-3477; Hinder, Lucy/0000-0002-5206-8010;
   Feldman, Eva/0000-0002-9162-2694
FU Program for Neurology Research Discovery; A. Alfred Taubman Medical
   Research Institute; Juvenile Diabetes Research Foundation
FX The authors would like to thank Mrs. Judith Bentley for excellent
   administrative support during the preparation of this article. Funding
   support is provided by the Program for Neurology Research & Discovery
   and the A. Alfred Taubman Medical Research Institute. L.M.H. is funded
   by a fellowship from the Juvenile Diabetes Research Foundation.
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NR 113
TC 68
Z9 79
U1 3
U2 41
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1523-0864
EI 1557-7716
J9 ANTIOXID REDOX SIGN
JI Antioxid. Redox Signal.
PD AUG 1
PY 2014
VL 21
IS 4
BP 621
EP 633
DI 10.1089/ars.2013.5807
PG 13
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA AM2DP
UT WOS:000339659600007
PM 24382087
OA Green Published
DA 2025-06-11
ER

PT J
AU Yao, ST
   Tian, H
   Zhao, L
   Li, JG
   Yang, LB
   Yue, F
   Li, YY
   Jiao, P
   Yang, NN
   Wang, YW
   Zhang, XJ
   Qin, SC
AF Yao, Shutong
   Tian, Hua
   Zhao, Li
   Li, Jinguo
   Yang, Libo
   Yue, Feng
   Li, Yanyan
   Jiao, Peng
   Yang, Nana
   Wang, Yiwei
   Zhang, Xiangjian
   Qin, Shucun
TI Oxidized high density lipoprotein induces macrophage apoptosis via
   toll-like receptor 4-dependent CHOP pathway
SO JOURNAL OF LIPID RESEARCH
LA English
DT Article
DE endoplasmic reticulum stress; CCAAT-enhancer-binding protein homologous
   protein; atherosclerosis; oxidative stress
ID ENDOPLASMIC-RETICULUM STRESS; THERAPEUTIC TARGET; CHOLESTEROL EFFLUX;
   ENDOTHELIAL-CELLS; HDL-C; LDL; ATHEROSCLEROSIS; ACCUMULATION; PROMOTES;
   CONTRIBUTES
AB Oxidized HDL (ox-HDL), unlike native HDL that exerts antiatherogenic effects, plays a proatherogenic role. However, the underlying mechanisms are not completely understood. This study was designed to explore the inductive effect of ox-HDL on endoplasmic reticulum (ER) stress-CCAAT-enhancer-binding protein homologous protein (CHOP)-mediated macrophage apoptosis and its upstream mechanisms. Our results showed that ox-HDL could be ingested by macrophages, causing intracellular lipid accumulation. As with tunicamycin (an ER stress inducer), ox-HDL induced macrophage apoptosis with concomitant activation of ER stress pathway, including nuclear translocation of activating transcription factor 6, phosphorylation of protein kinase-like ER kinase and eukaryotic translation initiation factor 2 alpha, and upregulation of glucose-regulated protein 78 and CHOP, which were inhibited by 4-phenylbutyric acid (PBA, an ER stress inhibitor) and CHOP gene silencing. Additionally, diphenyleneiodonium (DPI, an oxidative stress inhibitor), probucol (a reactive oxygen species scavenger), and toll-like receptor 4 (TLR4) silencing reduced ox-HDL-induced macrophage apoptosis, oxidative stress, and CHOP upregulation. Moreover, HDL isolated from patients with metabolic syndrome induced macrophage apoptosis, oxidative stress, and CHOP upregulation, which were blocked by PBA and DPI.(Jlr) These data indicate that ox-HDL may activate ER stress-CHOP-induced apoptotic pathway in macrophages via enhanced oxidative stress and that this pathway may be mediated by TLR4.
C1 [Yao, Shutong; Tian, Hua; Li, Yanyan; Jiao, Peng; Yang, Nana; Qin, Shucun] Taishan Med Univ, Key Lab Atherosclerosis Univ Shandong, Tai An, Shandong, Peoples R China.
   [Yao, Shutong; Tian, Hua; Li, Yanyan; Jiao, Peng; Yang, Nana; Qin, Shucun] Taishan Med Univ, Inst Atherosclerosis, Tai An, Shandong, Peoples R China.
   [Yao, Shutong; Li, Jinguo] Taishan Med Univ, Coll Basic Med Sci, Tai An, Shandong, Peoples R China.
   [Zhao, Li; Wang, Yiwei] Chengde Med Univ, Affiliated Hosp, Chengde, Peoples R China.
   [Yang, Libo; Yue, Feng] Cent Hosp Taian, Dept Endocrinol, Tai An, Shandong, Peoples R China.
   [Zhang, Xiangjian] Hebei Collaborat Innovat Ctr Cardiocerebrovasc Di, Hebei Key Lab Vasc Homeostasis, Shijiazhuang, Peoples R China.
C3 Shandong First Medical University & Shandong Academy of Medical
   Sciences; Taishan University; Shandong First Medical University &
   Shandong Academy of Medical Sciences; Taishan University; Taishan
   University; Shandong First Medical University & Shandong Academy of
   Medical Sciences; Chengde Medical University
RP Qin, SC (corresponding author), Taishan Med Univ, Key Lab Atherosclerosis Univ Shandong, Tai An, Shandong, Peoples R China.; Qin, SC (corresponding author), Taishan Med Univ, Inst Atherosclerosis, Tai An, Shandong, Peoples R China.
EM shucunqin@hotmail.com
RI Li, YanY/ABC-3649-2020
OI Zhang, Xiangjian/0000-0003-0114-1668
FU Taishan Scholars Foundation of Shandong Province [ts201511057]; National
   Natural Science Foundations of China [81370381, 81570410, 91539114]
FX This research was supported by the Taishan Scholars Foundation of
   Shandong Province (ts201511057) and the National Natural Science
   Foundations of China (81370381, 81570410, 91539114). The authors declare
   no conflicts of interest.
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NR 53
TC 31
Z9 71
U1 1
U2 14
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0022-2275
EI 1539-7262
J9 J LIPID RES
JI J. Lipid Res.
PD JAN
PY 2017
VL 58
IS 1
BP 164
EP 177
DI 10.1194/jlr.M071142
PG 14
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA EI3RJ
UT WOS:000392408700013
PM 27895089
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Su, QZ
   Baker, C
   Christian, P
   Naples, M
   Tong, XD
   Zhang, KZ
   Santha, M
   Adeli, K
AF Su, Qiaozhu
   Baker, Chris
   Christian, Patricia
   Naples, Mark
   Tong, Xuedong
   Zhang, Kezhong
   Santha, Miklos
   Adeli, Khosrow
TI Hepatic mitochondrial and ER stress induced by defective PPARα signaling
   in the pathogenesis of hepatic steatosis
SO AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
LA English
DT Article
DE peroxisome proliferator-activated receptor-alpha; endoplasmic reticulum;
   mitochondrial and endoplasmic reticulum stress; apolipoprotein B;
   very-low density lipoprotein; hepatic steatosis
ID ENDOPLASMIC-RETICULUM STRESS; APOLIPOPROTEIN B100 SECRETION; ACTIVATED
   RECEPTOR-ALPHA; INSULIN-RESISTANCE; LIPID-METABOLISM; MAMMALIAN-CELLS;
   EXPRESSION; OBESITY; REINITIATION; INFLAMMATION
AB Emerging evidence demonstrates a close interplay between disturbances in mitochondrial function and ER homeostasis in the development of the metabolic syndrome. The present investigation sought to advance our understanding of the communication between mitochondrial dysfunction and ER stress in the onset of hepatic steatosis in male rodents with defective peroxisome proliferator-activated receptor-alpha (PPAR alpha) signaling. Genetic depletion of PPAR alpha or perturbation of PPAR alpha signaling by high-fructose diet compromised the functional activity of metabolic enzymes involved in mitochondrial fatty acid alpha-oxidation and induced hepatic mitochondrial stress in rats and mice. Inhibition of PPAR alpha activity further enhanced the expression of apolipoprotein B (apoB) mRNA and protein, which was associated with reduced mRNA expression of the sarco/endoplasmic reticulum calcium ATPase (SERCA), the induction of hepatic ER stress, and hepatic steatosis. Restoration of PPAR alpha activity recovered the metabolic function of the mitochondria and ER, alleviated systemic hypertriglyceridemia, and improved hepatic steatosis. These findings unveil novel roles for PPAR alpha in mediating stress signals between hepatic subcellular stress-responding machinery and in the onset of hepatic steatosis under conditions of metabolic stress.
C1 [Su, Qiaozhu; Baker, Chris; Christian, Patricia; Naples, Mark; Adeli, Khosrow] Univ Toronto, Hosp Sick Children, Program Mol Struct & Funct, Toronto, ON M5G 1X8, Canada.
   [Su, Qiaozhu; Tong, Xuedong] Univ Nebraska, Dept Nutr & Hlth Sci, Lincoln, NE USA.
   [Zhang, Kezhong] Wayne State Univ, Detroit, MI USA.
   [Santha, Miklos] Hungarian Acad Sci, Inst Biochem, Szeged, Hungary.
   [Santha, Miklos] Hungarian Acad Sci, Biol Res Ctr, H-6701 Szeged, Hungary.
C3 University of Toronto; Hospital for Sick Children (SickKids); University
   of Nebraska System; University of Nebraska Lincoln; Wayne State
   University; HUN-REN; HUN-REN Biological Research Center; Institute of
   Biochemistry - HAS; Hungarian Academy of Sciences; HUN-REN; HUN-REN
   Biological Research Center; Hungarian Academy of Sciences
RP Adeli, K (corresponding author), Hosp Sick Children, DPLM, Div Clin Biochem, 555 Univ Ave, Toronto, ON M5G 1X8, Canada.
EM k.adeli@utoronto.ca
RI Zhang, Zhiwu/P-6156-2016; Tong, Xuedong/ABR-9313-2022
OI Adeli, Khosrow/0000-0002-5839-5709; Su, Qiaozhu/0000-0001-8434-1408;
   Zhang, Kezhong/0000-0002-6062-235X; Tong, Xuedong/0000-0002-0450-2564
FU Heart and Stroke Foundation of Ontario; Postdoctoral Research Fellowship
   from the Canadian Institutes of Health Research (CIHR); CIHR Strategic
   Training Program in Protein Folding and Interaction Dynamics Studentship
   from the University of Toronto; National Institute of Diabetes and
   Digestive and Kidney Diseases [P30DK020572] Funding Source: NIH RePORTER
FX This work was supported by an operating grant from the Heart and Stroke
   Foundation of Ontario to K. Adeli. Q. Su was supported by a Postdoctoral
   Research Fellowship from the Canadian Institutes of Health Research
   (CIHR). P. Christian is a recipient of the CIHR Strategic Training
   Program in Protein Folding and Interaction Dynamics Studentship from the
   University of Toronto.
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NR 35
TC 64
Z9 67
U1 0
U2 17
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0193-1849
EI 1522-1555
J9 AM J PHYSIOL-ENDOC M
JI Am. J. Physiol.-Endocrinol. Metab.
PD JUN
PY 2014
VL 306
IS 11
BP E1264
EP E1273
DI 10.1152/ajpendo.00438.2013
PG 10
WC Endocrinology & Metabolism; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Physiology
GA AJ7SI
UT WOS:000337897000005
PM 24735884
OA Green Published
DA 2025-06-11
ER

PT J
AU Speelman, T
   Dale, L
   Louw, A
   Verhoog, NJD
AF Speelman, Tammy
   Dale, Lieke
   Louw, Ann
   Verhoog, Nicolette J. D.
TI The Association of Acute Phase Proteins in Stress and
   Inflammation-Induced T2D
SO CELLS
LA English
DT Review
DE acute phase response; acute phase proteins; insulin resistance; type II
   diabetes; glucocorticoids; pro-inflammatory cytokines
ID PLASMINOGEN-ACTIVATOR INHIBITOR-1; C-REACTIVE PROTEIN;
   NECROSIS-FACTOR-ALPHA; SERUM AMYLOID-A; INSULIN-RECEPTOR SUBSTRATE-1;
   ADIPOSE-TISSUE DEVELOPMENT; PAI-1 GENE-EXPRESSION; NF-KAPPA-B;
   TNF-ALPHA; METABOLIC SYNDROME
AB Acute phase proteins (APPs), such as plasminogen activator inhibitor-1 (PAI-1), serum amyloid A (SAA), and C-reactive protein (CRP), are elevated in type-2 diabetes (T2D) and are routinely used as biomarkers for this disease. These APPs are regulated by the peripheral mediators of stress (i.e., endogenous glucocorticoids (GCs)) and inflammation (i.e., pro-inflammatory cytokines), with both implicated in the development of insulin resistance, the main risk factor for the development of T2D. In this review we propose that APPs, PAI-1, SAA, and CRP, could be the causative rather than only a correlative link between the physiological elements of risk (stress and inflammation) and the development of insulin resistance.
C1 [Speelman, Tammy; Dale, Lieke; Louw, Ann; Verhoog, Nicolette J. D.] Stellenbosch Univ, Biochem Dept, Van Byl St, ZA-7200 Stellenbosch, South Africa.
C3 Stellenbosch University
RP Verhoog, NJD (corresponding author), Stellenbosch Univ, Biochem Dept, Van Byl St, ZA-7200 Stellenbosch, South Africa.
EM tammyspee195@gmail.com; liekedale@gmail.com; al@sun.ac.za;
   nverhoog@sun.ac.za
RI Louw, Ann/A-7620-2012
OI Verhoog, Nicolette/0000-0002-3786-6452
FU Medical Research Council of South Africa
FX This research was funded by the Medical Research Council of South
   Africa.
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   INSULIN RESISTANCE S
NR 213
TC 15
Z9 16
U1 1
U2 9
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2073-4409
J9 CELLS-BASEL
JI Cells
PD JUL
PY 2022
VL 11
IS 14
AR 2163
DI 10.3390/cells11142163
PG 20
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA 3I1BJ
UT WOS:000832459800001
PM 35883605
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Arias-Loza, PA
   Muehlfelder, M
   Pelzer, T
AF Arias-Loza, Paula-Anahi
   Muehlfelder, Melanie
   Pelzer, Theo
TI Estrogen and estrogen receptors in cardiovascular oxidative stress
SO PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
LA English
DT Review
DE Estrogens; ROS; Oxidative stress; 17 beta-Estradiol; Cardiovascular
   system
ID NITRIC-OXIDE SYNTHASE; CEREBRAL BLOOD-VESSELS; MYOCARDIAL-INFARCTION;
   ENDOTHELIAL-CELLS; NADPH OXIDASES; OVARIECTOMIZED RATS; IN-VIVO;
   SUPEROXIDE GENERATION; GENDER-DIFFERENCES; METABOLIC SYNDROME
AB The cardiovascular system of a premenopausal woman is prepared to adapt to the challenges of increased cardiac output and work load that accompany pregnancy. Thus, it is tempting to speculate whether enhanced adaptability of the female cardiovascular system might be advantageous under conditions that promote cardiovascular disease. In support of this concept, 17 beta-estradiol as the major female sex hormone has been shown to confer protective cardiovascular effects in experimental studies. Mechanistically, these have been partially linked to the prevention and protection against oxidative stress. Current evidence indicates that estrogens attenuate oxidative stress at two levels: first, by preventing generation of reactive oxygen species (ROS) and, second, by scavenging ROS in the myocardium and in the vasculature. The purpose of this review is to give an overview on current concepts on conditions and mechanisms by which estrogens protect the cardiovascular system against ROS-mediated cellular injury.
C1 [Arias-Loza, Paula-Anahi; Muehlfelder, Melanie; Pelzer, Theo] Univ Hosp Wurzburg, Dept Internal Med 1, D-97080 Wurzburg, Germany.
   [Pelzer, Theo] Univ Hosp Wurzburg, Dept Med Cardiol & Pneumol ZIM 1, D-97080 Wurzburg, Germany.
C3 University of Wurzburg; University of Wurzburg
RP Pelzer, T (corresponding author), Univ Hosp Wurzburg, Dept Med Cardiol & Pneumol ZIM 1, Oberduerrbacher Str 6, D-97080 Wurzburg, Germany.
EM pelzer_t@klinik.uni-wuerzburg.de
OI Arias-Loza, Anahi-Paula/0000-0003-4048-4719
FU Interdisciplinary Center for Clinical Research Wurzburg [Z-2/21, F-144];
   Comprehensive Heart Failure Center Wurzburg [CHFC D-5]; Bayer Pharma AG
   Berlin
FX T.P. received support from the Interdisciplinary Center for Clinical
   Research Wurzburg (Z-2/21 and F-144) and the Comprehensive Heart Failure
   Center Wurzburg (CHFC D-5).T.P. has received financial support from the
   Bayer Pharma AG Berlin that relates to the evaluation of novel steroid
   hormone receptor ligands.
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NR 68
TC 57
Z9 63
U1 1
U2 29
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0031-6768
J9 PFLUG ARCH EUR J PHY
JI Pflugers Arch.
PD MAY
PY 2013
VL 465
IS 5
BP 739
EP 746
DI 10.1007/s00424-013-1247-7
PG 8
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA 143MO
UT WOS:000318871800015
PM 23417608
DA 2025-06-11
ER

PT S
AU Naito, Y
   Yoshikawa, T
AF Naito, Yuji
   Yoshikawa, Toshikazu
BE Yoshikawa, T
TI Oxidative Stress-induced Posttranslational Modification of Proteins as a
   Target of Functional Food
SO FOOD FACTORS FOR HEALTH PROMOTION
SE Forum of Nutrition
LA English
DT Article; Book Chapter
ID MANGANESE-SUPEROXIDE-DISMUTASE; ACID-BINDING PROTEIN;
   LIPID-PEROXIDATION; 4-HYDROXY-2-NONENAL-MODIFIED PROTEINS; THIOREDOXIN
   REDUCTASE; MEDIATED NITRATION; MONOCLONAL-ANTIBODY; INSULIN-RESISTANCE;
   RAT MODEL; IN-VITRO
AB In lifestyle-related diseases including metabolic syndrome, atherosclerosis, and cancer, oxidative stress is indicated by several markers, among which are lipid peroxides, aldehydes, and nitrotyrosine. We hypothesized that identification of proteins that are posttranslationally modified due to oxidative stress would lead to a greater understanding of some of the potential molecular mechanisms involved in degeneration and inflammation in these disorders. Proteomics is an emerging method for identification of proteins and their modification residues, and its application to food factor science is just beginning. Especially, we can obtain several monoclonal antibodies to detect specifically oxidized proteins, which can be applied to analysis by immunostaining or immunoblot. In this review, we present the use of these monoclonal antibodies in several diseases, from which new insights have emerged into mechanisms of metabolism and inflammation in these disorders that are associated with oxidative stress. Copyright (C) 2009 S. Karger AG, Basel
C1 [Naito, Yuji] Kyoto Prefectural Univ Med, Kamigyo Ku, Kyoto 6028566, Japan.
C3 Kyoto Prefectural University of Medicine
RP Naito, Y (corresponding author), Kyoto Prefectural Univ Med, Kamigyo Ku, Kyoto 6028566, Japan.
EM ynaito@koto.kpu-m.ac.jp
RI Naito, Yuji/D-1213-2010
FU Grants-in-Aid for Scientific Research [21390184] Funding Source: KAKEN
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NR 65
TC 6
Z9 6
U1 0
U2 3
PU KARGER
PI BASEL
PA POSTFACH, CH-4009 BASEL, SWITZERLAND
SN 1660-0347
BN 978-3-8055-9097-6
J9 FORUM NUTR
JI Forum Nutr.
PY 2009
VL 61
BP 39
EP 54
DI 10.1159/000212737
PG 16
WC Nutrition & Dietetics
WE Book Citation Index – Science (BKCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA BKJ08
UT WOS:000268245400004
PM 19367109
DA 2025-06-11
ER

PT J
AU Boudina, S
AF Boudina, Sihem
TI Cardiac Aging and Insulin Resistance: Could Insulin/Insulin-Like Growth
   Factor (IGF) Signaling be used as a Therapeutic Target?
SO CURRENT PHARMACEUTICAL DESIGN
LA English
DT Article
DE Insulin signaling; cardiac function; cardiac aging; mitochondria;
   reactive oxygen species; autophagy; fibrosis
ID AGE-RELATED-CHANGES; RAT-HEART MITOCHONDRIA; CARDIOVASCULAR-DISEASE
   ENTERPRISES; MANGANESE SUPEROXIDE-DISMUTASE; ENDOPLASMIC-RETICULUM
   STRESS; OXIDATIVE STRESS; ELECTRON-TRANSPORT; PERMEABILITY TRANSITION;
   ENDOTHELIAL DYSFUNCTION; METABOLIC SYNDROME
AB Intrinsic cardiac aging is an independent risk factor for cardiovascular disease and is associated with structural and functional changes that impede cardiac responses to stress and to cardio-protective mechanisms. Although systemic insulin resistance and the associated risk factors exacerbate cardiac aging, cardiac-specific insulin resistance without confounding systemic alterations, could prevent cardiac aging. Thus, strategies aimed to reduce insulin/insulin-like growth factor (IGF) signaling in the heart prevent cardiac aging in lower organisms and in mammals but the mechanisms underlying this protection are not fully understood. In this review, we describe the impact of aging on the cardiovascular system and discuss the mounting evidence that reduced insulin/IGF signaling in the heart could alleviate age-associated alterations and preserve cardiac performance.
C1 [Boudina, Sihem] Univ Utah, Sch Med, Div Endocrinol Metab & Diabet, Salt Lake City, UT 84112 USA.
   [Boudina, Sihem] Univ Utah, Sch Med, Program Mol Med, Salt Lake City, UT 84112 USA.
C3 Utah System of Higher Education; University of Utah; Utah System of
   Higher Education; University of Utah
RP Boudina, S (corresponding author), Program Human Mol Biol & Genet, Div Endocrinol Metab & Diabet, 15 N 2030 Bldg 533 Rm 3410B, Salt Lake City, UT 84112 USA.
EM sihem.boudina@hmbg.utah.edu
FU American Heart Association [09SDG2220218]; National Institutes of Health
   (NIH) [P30-HL-101310]; American Heart Association (AHA) [09SDG2220218]
   Funding Source: American Heart Association (AHA)
FX This work was supported by grants 09SDG2220218 from the American Heart
   Association and P30-HL-101310 from the National Institutes of Health
   (NIH) to Sihem Boudina. S.B. researched the literature, wrote,
   constructed and edited the manuscript.
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NR 191
TC 28
Z9 30
U1 0
U2 11
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1381-6128
EI 1873-4286
J9 CURR PHARM DESIGN
JI Curr. Pharm. Design
PD OCT
PY 2013
VL 19
IS 32
BP 5684
EP 5694
DI 10.2174/1381612811319320004
PG 11
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 207PK
UT WOS:000323614200004
PM 23448491
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Gendle, MH
   Spaeth, AM
   Dollard, SM
   Novaky, CA
AF Gendle, Mathew H.
   Spaeth, Andrea M.
   Dollard, Sarah M.
   Novaky, Cindy A.
TI Functional relationships between serum total cholesterol levels,
   executive control, and sustained attention
SO NUTRITIONAL NEUROSCIENCE
LA English
DT Article
DE total cholesterol; cognition; stress; executive control; sustained
   attention
ID HIGH-FAT DIETS; PREFRONTAL CORTICAL FUNCTION; NUTRITION EXAMINATION
   SURVEY; 3RD NATIONAL-HEALTH; COGNITIVE FUNCTION; POSTPRANDIAL LIPEMIA;
   METABOLIC SYNDROME; LIPOPROTEIN RECEPTORS; NORMOLIPIDEMIC ADULTS;
   CARBOHYDRATE CONTENT
AB This study investigated the potential relationship between serum total cholesterol (TC) and two specific aspects of cognition a (executive control and sustained attention) in a non-elderly sample, after controlling for life stress and several sociodemographic and health variables. For each participant (n = 46), measurements of TC, physical healthe and life stress were obtained, and executive control and sustained attention were assessed using the Tower of London and the Digit Vigilance Test. The outcomes of these cognitive assessments were correlated with TC, and a co-variate-adjusted analysis was performed. After controlling for several co-variates, TC was found to be significantly negatively associated with components of executive control and sustained attention. Because these cognitive functions are crucial in the moment-to-moment regulation of behavior, elevated TC may have negative behavioral consequences in everyday life situations.
C1 [Gendle, Mathew H.; Spaeth, Andrea M.; Dollard, Sarah M.] Elon Univ, Dept Psychol, Elon, NC 27244 USA.
   [Novaky, Cindy A.] Elon Univ, Univ Wellness Coordinator, Elon, NC 27244 USA.
C3 Elon University; Elon University
RP Gendle, MH (corresponding author), Elon Univ, Dept Psychol, 2337 Campus Box, Elon, NC 27244 USA.
EM mgendle@elon.edu
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NR 94
TC 7
Z9 9
U1 0
U2 8
PU MANEY PUBLISHING
PI LEEDS
PA STE 1C, JOSEPHS WELL, HANOVER WALK, LEEDS LS3 1AB, W YORKS, ENGLAND
SN 1028-415X
J9 NUTR NEUROSCI
JI Nutr. Neurosci.
PD APR
PY 2008
VL 11
IS 2
BP 84
EP 94
DI 10.1179/147683008X301469
PG 11
WC Neurosciences; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Nutrition & Dietetics
GA 317DH
UT WOS:000256999300006
PM 18510808
DA 2025-06-11
ER

PT J
AU Puttabyatappa, M
   Martin, JD
   Andriessen, V
   Stevenson, M
   Zeng, LX
   Pennathur, S
   Padmanabhan, V
AF Puttabyatappa, Muraly
   Martin, Jacob D.
   Andriessen, Victoria
   Stevenson, Micaela
   Zeng, Lixia
   Pennathur, Subramaniam
   Padmanabhan, Vasantha
TI Developmental programming: Changes in mediators of insulin sensitivity
   in prenatal bisphenol A-treated female sheep
SO REPRODUCTIVE TOXICOLOGY
LA English
DT Article
DE Endocrine disruptor; Bisphenol A; Insulin resistance; Oxidative stress;
   Inflammation; Lipotoxicity
ID ENDOCRINE-DISRUPTING CHEMICALS; UMBILICAL-CORD SERUM; OXIDATIVE STRESS;
   ADIPOSE-TISSUE; BPA EXPOSURE; TESTOSTERONE EXCESS; METABOLIC SYNDROME;
   SEX STEROIDS; LH SURGE; RESISTANCE
AB Developmental exposure to endocrine disruptor bisphenol A (BPA) is associated with metabolic defects during adulthood. In sheep, prenatal BPA treatment causes insulin resistance (IR) and adipocyte hypertrophy in the female offspring. To determine if changes in insulin sensitivity mediators (increase in inflammation, oxidative stress, and lipotoxicity and/or decrease in adiponectin) and the intracrine steroidal milieu contributes to these metabolic perturbations, metabolic tissues collected from 21-month-old female offspring born to mothers treated with 0, 0.05, 0.5, or 5 mg/kg/day of BPA were studied. Findings showed prenatal BPA in non-monotonic manner (1) increased oxidative stress; (2) induced lipotoxicity in liver and muscle; and (3) increased aromatase and estrogen receptor expression in visceral adipose tissues. These changes are generally associated with the development of peripheral and tissue level IR and may explain the IR status and adipocyte hypertrophy observed in prenatal BPA-treated female sheep.
C1 [Puttabyatappa, Muraly; Martin, Jacob D.; Andriessen, Victoria; Stevenson, Micaela; Padmanabhan, Vasantha] Univ Michigan, Dept Pediat, MSRB1 7510,1500 W Med Ctr Dr, Ann Arbor, MI 48109 USA.
   [Zeng, Lixia; Pennathur, Subramaniam] Univ Michigan, Dept Internal Med, Ann Arbor, MI 48109 USA.
   [Pennathur, Subramaniam; Padmanabhan, Vasantha] Univ Michigan, Dept Mol Physiol, Ann Arbor, MI 48109 USA.
   [Pennathur, Subramaniam; Padmanabhan, Vasantha] Univ Michigan, Dept Integrat Physiol, Ann Arbor, MI 48109 USA.
C3 University of Michigan System; University of Michigan; University of
   Michigan System; University of Michigan; University of Michigan System;
   University of Michigan; University of Michigan System; University of
   Michigan
RP Padmanabhan, V (corresponding author), Univ Michigan, Dept Pediat, MSRB1 7510,1500 W Med Ctr Dr, Ann Arbor, MI 48109 USA.
EM vasantha@umich.edu
RI Puttabyatappa, Muraly/K-2598-2015; Pennathur, Subramaniam/O-7032-2017;
   Stevenson, Micaela/JPA-0105-2023; Padmanabhan, Vasantha/C-8558-2017
OI Pennathur, Subramaniam/0000-0003-3628-6883
FU National Institute of Environmental Health Sciences [R01-ES-016541];
   Ruth L. Kirschstein Institutional Training Grant from the National
   Institutes of Health/National Institute for Environmental Health
   Sciences [T32 ES007062]; National Institute of Diabetes and Digestive
   and Kidney Diseases [P30DK020572] Funding Source: NIH RePORTER; National
   Institute of Environmental Health Sciences [P30ES017885, T32ES007062]
   Funding Source: NIH RePORTER
FX This work was supported by National Institute of Environmental Health
   Sciences Grant R01-ES-016541 (VP) and Ruth L. Kirschstein Institutional
   Training Grant from the National Institutes of Health/National Institute
   for Environmental Health SciencesT32 ES007062 to MP
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NR 91
TC 22
Z9 23
U1 0
U2 4
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0890-6238
J9 REPROD TOXICOL
JI Reprod. Toxicol.
PD APR
PY 2019
VL 85
BP 110
EP 122
DI 10.1016/j.reprotox.2019.03.002
PG 13
WC Reproductive Biology; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Reproductive Biology; Toxicology
GA HT5TH
UT WOS:000464625700015
PM 30853570
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Wu, WW
   Xu, H
   Wang, ZM
   Mao, Y
   Yuan, LS
   Luo, W
   Cui, ZQ
   Cui, TX
   Wang, XL
   Shen, YH
AF Wu, Weiwei
   Xu, Hao
   Wang, Zemin
   Mao, Yun
   Yuan, Liangshuai
   Luo, Wei
   Cui, Zhaoqiang
   Cui, Taixing
   Wang, Xing Li
   Shen, Ying H.
TI PINK1-Parkin-Mediated Mitophagy Protects Mitochondrial Integrity and
   Prevents Metabolic Stress-Induced Endothelial Injury
SO PLOS ONE
LA English
DT Article
ID MUTATIONS; DISEASE; PARKIN; REGULATORS; AUTOPHAGY; MEMBRANE
AB Mitochondrial injury and dysfunction, a significant feature in metabolic syndrome, triggers endothelial cell dysfunction and cell death. Increasing evidence suggests that mitophagy, a process of autophagic turnover of damaged mitochondria, maintains mitochondrial integrity. PINK1 (phosphatase and tensin homolog (PTEN)-induced putative kinase 1) and Parkin signaling is a key pathway in mitophagy control. In this study, we examined whether this pathway could protect mitochondria under metabolic stress. We found that palmitic acid (PA) induced significant mitophagy and activated PINK1 and Parkin in endothelial cells. Knocking down PINK1 or Parkin reduced mitophagy, leading to impaired clearance of damaged mitochondria and intracellular accumulation of mitochondrial fragments. Furthermore, PINK1 and Parkin prevented PA-induced mitochondrial dysfunction, ROS production and apoptosis. Finally, we show that PINK1 and Parkin were up-regulated in vascular wall of obese mice and diabetic mice. Our study demonstrates that PINK1-Parkin pathway is activated in response to metabolic stress. Through induction of mitophagy, this pathway protects mitochondrial integrity and prevents metabolic stress-induced endothelial injury.
C1 [Wu, Weiwei; Xu, Hao; Wang, Zemin; Mao, Yun; Yuan, Liangshuai; Luo, Wei; Cui, Zhaoqiang; Cui, Taixing; Wang, Xing Li] Shandong Univ, Res Ctr Cell Therapy, Key Lab Cardiovasc Remodeling & Funct Res, Qilu Hosp, Jinan 250012, Peoples R China.
   [Cui, Taixing] Univ S Carolina, Dept Cell Biol & Anat, Columbus, SC 29209 USA.
   [Wang, Xing Li; Shen, Ying H.] Baylor Coll Med, Div Cardiothorac Surg, Michael E DeBakey Dept Surg, Houston, TX 77030 USA.
   [Wang, Xing Li; Shen, Ying H.] Texas Heart Inst, Houston, TX 77025 USA.
C3 Shandong University; University of South Carolina System; University of
   South Carolina Columbia; Baylor College of Medicine; Texas Heart
   Institute
RP Wang, XL (corresponding author), Shandong Univ, Res Ctr Cell Therapy, Key Lab Cardiovasc Remodeling & Funct Res, Qilu Hosp, Jinan 250012, Peoples R China.
EM xingliwang@sdu.edu.cn; hyshen@bcm.edu
RI wang, xingli/MHR-1399-2025; Wu, Weiwei/AFY-8257-2022; shen,
   ying/HHS-5635-2022
OI Luo, Wei/0000-0001-9416-9592
FU Shandong University National Qianren Scholar Fund; National 973 Program
   Grant [2014CB542401]
FX This work was supported by the Shandong University National Qianren
   Scholar Fund (XLW) and by the National 973 Program Grant (2014CB542401).
   The funders had no role in study design, data collection and analysis,
   decision to publish, or preparation of the manuscript.
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NR 26
TC 117
Z9 138
U1 0
U2 22
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JUL 10
PY 2015
VL 10
IS 7
AR e0132499
DI 10.1371/journal.pone.0132499
PG 14
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA CN1FD
UT WOS:000358162300142
PM 26161534
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Turgut, O
   Tandogan, I
AF Turgut, Okan
   Tandogan, Izzet
TI Gamma-glutamyltransferase to Determine Cardiovascular Risk: Shifting the
   Paradigm Forward
SO JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
LA English
DT Review
DE Cardiovascular risk; Gamma-glutamyltranferase; Oxidative stress;
   Prognosis
ID MALE WORKERS 3M; METABOLIC SYNDROME; OXIDATIVE STRESS;
   MYOCARDIAL-INFARCTION; PROGNOSTIC VALUE; HEART-DISEASE; FATTY LIVER;
   HIPOP-OHP; ATHEROSCLEROSIS; ASSOCIATION
AB Gamma-glutamyltransferase (GGT), regarded as a marker of excessive alcohol consumption or liver disturbances, is an enzyme catalyzing the first step in the extracellular degradation of the antioxidant glutathione (GSH) and may take part in atherogenesis. The marked relationship between GGT and the atherosclerotic process has shifted attention to the issue of whether its serum levels can aid in the detection of individuals at high risk for incident cardiovascular events. It is likely that the process entails the oxidation of low-density lipoprotein through GSH/GGT-dependent iron reduction within the plaque. In this context, oxidative stress is a probable mediator. Recent insights into the pathophysiological background of GGT in the precipitation and progression of atherosclerosis appear to be supported by relevant epidemiological observations as a cardiovascular risk predictor. Further understanding is, nevertheless, warranted to ameliorate the prognostic stratification of patients through GGT.
C1 [Turgut, Okan; Tandogan, Izzet] Cumhuriyet Univ, Dept Cardiol, Fac Med, TR-58140 Sivas, Turkey.
C3 Cumhuriyet University
RP Turgut, O (corresponding author), Cumhuriyet Univ, Dept Cardiol, Fac Med, TR-58140 Sivas, Turkey.
EM okanturgut@lycos.com
RI Turgut, Okan/C-4396-2008
OI Turgut, Okan/0000-0002-6847-3029
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NR 32
TC 54
Z9 58
U1 1
U2 6
PU JAPAN ATHEROSCLEROSIS SOC
PI TOKYO
PA NICHINAI-KAIKAN B1, 3-28-8 HONGO BUNKYO-KU, TOKYO, 113-0033, JAPAN
SN 1340-3478
EI 1880-3873
J9 J ATHEROSCLER THROMB
JI J. Atheroscler. Thromb.
PY 2011
VL 18
IS 3
BP 177
EP 181
DI 10.5551/jat.6189
PG 5
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 750FJ
UT WOS:000289530600001
PM 21041983
OA hybrid
DA 2025-06-11
ER

PT J
AU Sekiya, M
   Hiraishi, A
   Touyama, M
   Sakamoto, K
AF Sekiya, Mika
   Hiraishi, Ako
   Touyama, Maiko
   Sakamoto, Kazuichi
TI Oxidative stress induced lipid accumulation via SREBP1c activation in
   HepG2 cells
SO BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
LA English
DT Article
DE Fatty acid biosynthesis; Adipogenesis; ROS; Transcription factor
ID TRANSCRIPTION FACTOR; BINDING; INSULIN; PROTEIN; CLEAVAGE; OBESITY;
   KINASE
AB SREBP1c (sterol regulatory element-binding protein 1c) is a metabolic-syndrome-associated transcription factor that controls fatty acid biosynthesis under glucose/insulin stimulation. Oxidative stress increases lipid accumulation, which promotes the generation of reactive oxygen species (ROS). However, we know little about the role of oxidative stress in fatty acid biosynthesis. To clarify the action of oxidative stress in lipid accumulation via SREBP1c, we examined SREBP1c activity in H2O2-treated mammalian cells. We introduced a luciferase reporter plasmid carrying the SREBP1c-binding site into HepG2 or COS-7 cells. With increasing H2O2 dose, SREBP1c transcriptional activity increased in HepG2 cells but declined in COS-7 cells. RT-PCR analysis revealed that mRNA expression of SREBP1c gene or of SREBP1c-regulated genes rose H2O2 dose-dependently in HepG2 cells but dropped in COS-7 cells. Lipid accumulation and levels of the nuclear form of SREBP1c increased in H2O2-stimulated HepG2 cells. ROS may stimulate lipid accumulation in HepG2 cells via SREBP1c activation. (C) 2008 Elsevier Inc. All rights reserved.
C1 [Sekiya, Mika; Hiraishi, Ako; Touyama, Maiko; Sakamoto, Kazuichi] Univ Tsukuba, Grad Sch Life & Environm Sci, Tsukuba, Ibaraki 3058572, Japan.
C3 University of Tsukuba
RP Sakamoto, K (corresponding author), Univ Tsukuba, Grad Sch Life & Environm Sci, 1-1-1 Tennoudai, Tsukuba, Ibaraki 3058572, Japan.
EM sakamoto@biol.tsukuba.ac.jp
FU Ministry of Education, Science, Sports, and Culture of Japan
FX We thank Dr. Hitoshi Shimano (University of Tsukuba) for providing
   plasmid of pGL2-basic SREBP1 c (-2.6 kb) promoter Luc. This work was
   supported in part by Grants-in-Aid for Scientific Research from the
   Ministry of Education, Science, Sports, and Culture of Japan.
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NR 23
TC 142
Z9 152
U1 6
U2 35
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0006-291X
EI 1090-2104
J9 BIOCHEM BIOPH RES CO
JI Biochem. Biophys. Res. Commun.
PD OCT 31
PY 2008
VL 375
IS 4
BP 602
EP 607
DI 10.1016/j.bbrc.2008.08.068
PG 6
WC Biochemistry & Molecular Biology; Biophysics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics
GA 356HL
UT WOS:000259769200023
PM 18727921
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Liu, Y
   Zhai, MM
   Guo, F
   Shi, TR
   Liu, JZ
   Wang, X
   Zhang, XD
   Jing, D
   Hai, CX
AF Liu, Ying
   Zhai, Mingming
   Guo, Fan
   Shi, Tengrui
   Liu, Jiangzheng
   Wang, Xin
   Zhang, Xiaodi
   Jing, Da
   Hai, Chunxu
TI Whole Body Vibration Improves Insulin Resistance in db/db Mice:
   Amelioration of Lipid Accumulation and Oxidative Stress
SO APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
LA English
DT Article
DE Insulinresistance; Liver steatosis; Oxidative stress; Glutathione
   peroxidases; Whole body vibration
ID TYPE-2 DIABETES-MELLITUS; FATTY LIVER-DISEASE; GLUTATHIONE PEROXIDASES;
   METABOLIC SYNDROME; WEIGHT-GAIN; EXERCISE; ACTIVATION; THERAPY; RISK;
   RATS
AB Insulin resistance (IR) is the hallmark of type 2 diabetes mellitus (T2DM), which is one of the most important chronic noncommunicable diseases. Effective and feasible strategies to treat IR are still urgently needed. Previous research studies reported that whole body vibration (WBV) was beneficial for IR in clinical; however, its underlying mechanisms remains unknown. In the present study, db/db mice were treated with WBV administration 60 min/day for 12 weeks and the impaired insulin sensitivity was improved. Besides, liver steatosis was also ameliorated. Further explorations revealed that WBV could reduce the expression of SREBP1c and increase the expression of GSH-Px and consequently suppress oxidative stress. In conclusion, WBV attenuates oxidative stress to ameliorate liver steatosis and thus improves insulin resistance in db/db mice. Therefore, WBV administration is a promising treatment for individuals who suffered from central obesity and IR.
C1 [Liu, Ying; Shi, Tengrui; Liu, Jiangzheng; Wang, Xin; Zhang, Xiaodi; Hai, Chunxu] Fourth Mil Med Univ, Sch Publ Hlth, Dept Toxicol,Shanxi Prov Key Lab Free Rad Biol &, Minist Educ,Key Lab Hazard Assessment & Control S, Xian 710032, Shaanxi, Peoples R China.
   [Zhai, Mingming; Jing, Da] Fourth Mil Med Univ, Dept Biomed Engn, Xian 710032, Peoples R China.
   [Guo, Fan] Fourth Mil Med Univ, Xijing Hosp, Dept Radiol, Xian 710032, Peoples R China.
C3 Ministry of Education - China; Air Force Medical University; Air Force
   Medical University; Air Force Medical University
RP Hai, CX (corresponding author), Fourth Mil Med Univ, Sch Publ Hlth, Dept Toxicol,Shanxi Prov Key Lab Free Rad Biol &, Minist Educ,Key Lab Hazard Assessment & Control S, Xian 710032, Shaanxi, Peoples R China.; Jing, D (corresponding author), Fourth Mil Med Univ, Dept Biomed Engn, Xian 710032, Peoples R China.
EM jingdaasq@126.com; cx-hai@fmmu.edu.cn
RI Zhang, Xiaodi/KIB-3120-2024; shi, teng/GSE-5879-2022; Wang,
   Xin/AAJ-6869-2020; Wang, Xin/S-5548-2016
OI Wang, Xin/0000-0002-7296-9406; di, ming ming/0000-0001-9793-2231
FU Program for Chankiang Scholars, Innovative Research Team in University
   (PCSIRT); National Nature Scientific Foundation [NSFC-81473010,
   NSFC-3140040159]; Natural Science Foundation of Shaanxi Province
   [2014JQ4135]
FX This work was supported by Program for Chankiang Scholars, Innovative
   Research Team in University (PCSIRT) and National Nature Scientific
   Foundation (NSFC-81473010 and NSFC-3140040159). This work was also
   supported by the Natural Science Foundation of Shaanxi Province
   (2014JQ4135).
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NR 47
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Z9 28
U1 1
U2 12
PU HUMANA PRESS INC
PI TOTOWA
PA 999 RIVERVIEW DRIVE SUITE 208, TOTOWA, NJ 07512 USA
SN 0273-2289
EI 1559-0291
J9 APPL BIOCHEM BIOTECH
JI Appl. Biochem. Biotechnol.
PD JUL
PY 2016
VL 179
IS 5
BP 819
EP 829
DI 10.1007/s12010-016-2033-8
PG 11
WC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology
GA DR2TC
UT WOS:000379755800010
PM 26945578
DA 2025-06-11
ER

PT J
AU Brietzke, E
   Kapczinski, F
   Grassi-Oliveira, R
   Grande, I
   Vieta, E
   McIntyre, RS
AF Brietzke, Elisa
   Kapczinski, Flavio
   Grassi-Oliveira, Rodrigo
   Grande, Iria
   Vieta, Eduard
   McIntyre, Roger S.
TI Insulin dysfunction and allostatic load in bipolar disorder
SO EXPERT REVIEW OF NEUROTHERAPEUTICS
LA English
DT Review
DE allostatic load; bipolar disorder; cognition; cytokines; early life
   stress; general medical comorbidities; HPA; insulin; neuroplasticity;
   oxidative stress
ID PITUITARY-ADRENAL AXIS; CORTICOTROPIN-RELEASING HORMONE; METABOLIC
   SYNDROME; SYNAPTIC PLASTICITY; COGNITIVE IMPAIRMENT; ALZHEIMERS-DISEASE;
   HIPPOCAMPAL PLASTICITY; INFLAMMATORY MARKERS; CARDIOVASCULAR RISK;
   MEMORY IMPAIRMENTS
AB Bipolar disorder (BD) is associated with substantial morbidity, as well as premature mortality. Available evidence indicates that 'stress-sensitive' chronic medical disorders, such as cardiovascular disease, obesity and Type 2 diabetes mellitus, are critical mediators and/or moderators of BD. Changes in physiologic systems implicated in allostasis have been proposed to impact brain structures and neurocognition, as well as medical comorbidity in this population. For example, abnormalities in insulin physiology, for example, insulin resistance, hyperinsulinemia and central insulinopenia, are implicated as effectors of allostatic load in BD. Insulin's critical role in CNS physiological (e.g., neurotrophism and synaptic plasticity) and pathophysiological (e.g., neurocognitive deficits, pro-apoptosis and amyloid deposition) processes is amply documented. This article introduces the concept that insulin is a mediator of allostatic load in the BD and possibly a therapeutic target.
C1 [Brietzke, Elisa] Univ Sao Paulo, Inst Psychiat, Bipolar Disorder Program, Sao Paulo, Brazil.
   [Kapczinski, Flavio] Univ Fed Rio Grande do Sul, Hosp Clin Porto Alegre, Bipolar Disorder Program, Porto Alegre, RS, Brazil.
   [Kapczinski, Flavio] Univ Fed Rio Grande do Sul, Hosp Clin Porto Alegre, Lab Mol Psychiat, Porto Alegre, RS, Brazil.
   [Kapczinski, Flavio; Grassi-Oliveira, Rodrigo] INCT TM, Natl Inst Translat Med, Porto Alegre, RS, Brazil.
   [Grassi-Oliveira, Rodrigo] Pontificia Univ Catolica Rio Grande do Sul, Dev Cognit Neurosci Res Grp, Porto Alegre, RS, Brazil.
   [Grande, Iria; Vieta, Eduard] Univ Barcelona, IDIBAPS, Bipolar Disorders Program, CIBERSAM,Inst Clin Neurosci,Hosp Clin, Barcelona, Spain.
   [McIntyre, Roger S.] Univ Toronto, Mood Disorders Psychopharmacol Unit, Toronto, ON, Canada.
C3 Universidade de Sao Paulo; Universidade Federal do Rio Grande do Sul;
   Hospital de Clinicas de Porto Alegre; Hospital de Clinicas de Porto
   Alegre; Universidade Federal do Rio Grande do Sul; Pontificia
   Universidade Catolica Do Rio Grande Do Sul; CIBER - Centro de
   Investigacion Biomedica en Red; CIBERSAM; University of Barcelona;
   Hospital Clinic de Barcelona; IDIBAPS; University of Toronto
RP Brietzke, E (corresponding author), Rua Prof Dr Ovidio Pires de Campos 785, BR-01060970 Sao Paulo, Brazil.
EM elisabrietzke@hotmail.com
RI Vieta, Eduard/Y-2919-2019; Grande, Iria/AAF-9342-2021; Brietzke,
   Elisa/G-9559-2012; McIntyre, Roger/AAU-1000-2020; Grassi-Oliveira,
   R/G-2623-2012; Grande, Iria/D-3072-2015; Vieta, Eduard/I-6330-2013;
   Kapczinski, Flavio/D-3175-2013
OI Grassi-Oliveira, Rodrigo/0000-0001-9911-5921; Grande,
   Iria/0000-0002-0137-0666; Vieta, Eduard/0000-0002-0548-0053; Kapczinski,
   Flavio/0000-0001-8738-856X
FU Stanley Medical Research Institute; National Alliance for Research on
   Schizophrenia and Depression (NARSAD); Eli Lilly; Janssen-Ortho; Shire;
   AstraZeneca; Pfizer; Bristol-Myers Squibb
FX Roger S McIntyre has received research grants from the Stanley Medical
   Research Institute, the National Alliance for Research on Schizophrenia
   and Depression (NARSAD), Eli Lilly, Janssen-Ortho, Shire, AstraZeneca
   and Pfizer. He is on the advisory boards for the following: AstraZeneca,
   Bristol-Myers Squibb, France Foundation, GlaxoSmithKline, Janssen-Ortho,
   Solvay/Wyeth, Eli Lilly, Organon, Lundbeck, Biovail, Pfizer, Shire,
   Schering-Plough and Merck, and on the speakers bureau for the following:
   Janssen-Ortho, Astra-Zeneca, Eli Lilly, Lundbeck, Biovail and Merck. He
   has also carried out CME activities for the following: AstraZeneca,
   Bristol-Myers Squibb, France Foundation, I3CME, Solvay/Wyeth,
   Physicians' Postgraduate Press, CME Outfitters, Optum Health,
   Schering-Plough, Merck and Eli Lilly and received travel funds from
   Bristol-Myers Squibb. The authors have no other relevant affiliations or
   financial involvement with any organization or entity with a financial
   interest in or financial conflict with the subject matter or materials
   discussed in the manuscript apart from those disclosed.
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NR 142
TC 56
Z9 59
U1 0
U2 27
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1473-7175
EI 1744-8360
J9 EXPERT REV NEUROTHER
JI Expert Rev. Neurother.
PD JUL
PY 2011
VL 11
IS 7
BP 1017
EP 1028
DI 10.1586/ERN.10.185
PG 12
WC Clinical Neurology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pharmacology & Pharmacy
GA 806YL
UT WOS:000293853900016
PM 21721918
OA Green Published
DA 2025-06-11
ER

PT J
AU Ge, DL
   Dong, YB
   Wang, XL
   Treiber, FA
   Snieder, H
AF Ge, Dongliang
   Dong, Yanbin
   Wang, Xiaoling
   Treiber, Frank A.
   Snieder, Harold
TI The Georgia Cardiovascular Twin Study: Influence of genetic
   predisposition and chronic stress on risk for cardiovascular disease and
   type 2 diabetes
SO TWIN RESEARCH AND HUMAN GENETICS
LA English
DT Article
ID HEART-RATE-VARIABILITY; RESPIRATORY SINUS ARRHYTHMIA; AMBULATORY
   BLOOD-PRESSURE; PULSE-WAVE VELOCITY; METABOLIC SYNDROME; HERITABILITY;
   AMERICAN; IMPACT; MORTALITY; POLYMORPHISMS
AB The Georgia Cardiovascular Twin Study is a longitudinal study of biobehavioral antecedents of cardiovascular disease in youth and young adults, including around 500 twin pairs with roughly equal numbers of African Americans and European Americans. Focus of study includes the longitudinal change in relative influence of genetic and environmental factors (especially chronic stress) on development of risk factors for cardiovascular disease. Approaches include quantitative genetic modeling of phenotypic twin data as well as the examination of the influence of polymorphic variation in candidate genes and their potential interaction with environmental factors on these risk factors. Future work will expand the scope of the study to investigating the impact of chronic stress as measured by indices of the hypothalamus-pituitary-adrenal axis and the sympathetic nervous system on preclinical markers of cardiovascular disease, essential hypertension and type 2 diabetes.
C1 Med Coll Georgia, Georgia Prevent Inst, Dept Pediat, Augusta, GA 30912 USA.
   Kings Coll London, Twin Res & Genet Epidemiol Unit, London WC2R 2LS, England.
C3 University System of Georgia; Augusta University; University of London;
   King's College London
RP Snieder, H (corresponding author), Med Coll Georgia, Georgia Prevent Inst, Dept Pediat, Bldg HS-1640, Augusta, GA 30912 USA.
EM hsnieder@mcg.edu
RI Ge, Dongliang/GYJ-5489-2022
FU NHLBI NIH HHS [HL 56622, HL 69999] Funding Source: Medline
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NR 41
TC 28
Z9 29
U1 0
U2 8
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
SN 1832-4274
EI 1839-2628
J9 TWIN RES HUM GENET
JI Twin Res. Hum. Genet.
PD DEC
PY 2006
VL 9
IS 6
BP 965
EP 970
DI 10.1375/183242706779462877
PG 6
WC Genetics & Heredity; Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Genetics & Heredity; Obstetrics & Gynecology
GA 122HO
UT WOS:000243216600045
PM 17254438
OA Bronze
DA 2025-06-11
ER

PT J
AU Huynh, VW
   Chiang, JJ
AF Huynh, Virginia W.
   Chiang, Jessica J.
TI Subjective Social Status and Adolescent Health: The Role of Stress and
   Sleep
SO YOUTH & SOCIETY
LA English
DT Article
DE status; health; sleep; stress; Latino; Asian
ID FUNCTIONAL SOMATIC SYMPTOMS; FAMILY SOCIOECONOMIC-STATUS;
   BLOOD-PRESSURE; METABOLIC SYNDROME; DURATION; INTERVENTION; ASSOCIATION;
   PREVALENCE; CHILDHOOD; AMERICANS
AB Despite adolescence being a period marked by significant social changes, research on social status focuses largely on adults. This study examined whether school and societal subjective social status (SSS) are differentially associated with adolescent health above and beyond objective socioeconomic status (SES), and explored pathways linking SSS to health. Latino (n = 169) and Asian American (n = 77) adolescents (M age = 17.23, SD = 0.74; 59% female) completed self-reports of SSS, sleep, stress, and somatic symptoms. Parents reported income and education. Blood pressure (BP) measurements were obtained. Results indicate that independent of objective SES, lower school SSS was associated with higher diastolic BP whereas lower societal SSS was associated with more somatic symptoms. Sleep disruptions and perceived stress mediated the association between societal SSS and somatic symptoms. Results suggest that SSS may be more important to adolescent health than objective SES. Furthermore, school and societal SSS may differentially affect indicators of health through different pathways.
C1 [Huynh, Virginia W.] Calif State Univ Northridge, Dept Child & Adolescent Dev, 18111 Nordhoff St, Northridge, CA 91330 USA.
   [Chiang, Jessica J.] Univ Calif Los Angeles, Dept Psychol, Los Angeles, CA USA.
C3 California State University System; California State University
   Northridge; University of California System; University of California
   Los Angeles
RP Huynh, VW (corresponding author), Calif State Univ Northridge, Dept Child & Adolescent Dev, 18111 Nordhoff St, Northridge, CA 91330 USA.
EM Virginia.huynh@csun.edu
OI huynh, virginia/0000-0002-9741-4482
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NR 65
TC 18
Z9 21
U1 1
U2 38
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0044-118X
EI 1552-8499
J9 YOUTH SOC
JI Youth Soc.
PD OCT
PY 2018
VL 50
IS 7
BP 926
EP 946
DI 10.1177/0044118X16646028
PG 21
WC Social Issues; Social Sciences, Interdisciplinary; Sociology
WE Social Science Citation Index (SSCI)
SC Social Issues; Social Sciences - Other Topics; Sociology
GA GS1ON
UT WOS:000443298800004
DA 2025-06-11
ER

PT J
AU Yasui, N
   Nishiyama, E
   Juman, S
   Negishi, H
   Miki, T
   Yamori, Y
   Ikeda, K
AF Yasui, Naomi
   Nishiyama, Emi
   Juman, Sachiko
   Negishi, Hiroko
   Miki, Tomohiro
   Yamori, Yukio
   Ikeda, Katsumi
TI Caffeic acid phenethyl ester suppresses oxidative stress in 3T3-L1
   adipocytes
SO JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
LA English
DT Article
DE CAPE; adipocyte; ROS; 3T3-L1
ID METABOLIC SYNDROME; DIFFERENTIATION; EXPRESSION; OBESITY
AB The generation of oxidative stress, characterized by enhanced reactive oxygen species (ROS) formation, has been found in obesity. ROS production was increased during the differentiation of 3T3-L1 cells into adipocytes. We previously reported that caffeic acid phenethyl ester (CAPE) suppresses 3T3-L1 differentiation to adipocytes through the inhibition of peroxisome proliferator-activated receptor . In this study, the preventive effect of CAPE on oxidative stress in 3T3-L1 cells was observed. The results were as follows: (1) ROS production during 3T3-L1 cell differentiation to adipocytes was significantly (p<0.05) suppressed by CAPE treatment in a concentration-dependent manner, (2) with CAPE treatment, the extracellular superoxide dismutase mRNA expression level significantly increased, but the NOX4 mRNA expression level did not change, and (3) CAPE treatment significantly increased superoxide dismutase (SOD) activity in 3T3-L1 cells. From these results, we suggest that the increased oxidative stress in 3T3-L1 differentiation to adipocytes is attenuated by CAPE treatment. This attenuation may be partly caused by increased SOD production.
C1 [Yasui, Naomi; Nishiyama, Emi; Juman, Sachiko; Miki, Tomohiro; Ikeda, Katsumi] Mukogawa Womens Univ, Sch Pharm & Pharmaceut Sci, Nishinomiya, Hyogo, Japan.
   [Negishi, Hiroko] Nara Womens Univ, Grad Sch Humanities & Sci, Nara 630, Japan.
   [Yamori, Yukio] Mukogawa Womens Univ, Inst World Hlth Dev, Nishinomiya, Hyogo, Japan.
C3 Mukogawa Women's University; Nara Womens University; Mukogawa Women's
   University
RP Ikeda, K (corresponding author), Mukogawa Womens Univ, Sch Pharm & Pharmaceut Sci, Nishinomiya, Hyogo, Japan.
EM ikeda@mukogawa-u.ac.jp
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NR 21
TC 17
Z9 18
U1 1
U2 23
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1028-6020
EI 1477-2213
J9 J ASIAN NAT PROD RES
JI J. Asian Nat. Prod. Res.
PD NOV 1
PY 2013
VL 15
IS 11
BP 1189
EP 1196
DI 10.1080/10286020.2013.825609
PG 8
WC Plant Sciences; Chemistry, Applied; Chemistry, Medicinal; Pharmacology &
   Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Chemistry; Pharmacology & Pharmacy
GA 270KC
UT WOS:000328316300008
PM 23927014
DA 2025-06-11
ER

PT J
AU Singh, R
   Singh, M
   Krishan, P
AF Singh, Randhir
   Singh, Manjeet
   Krishan, Pawan
TI Effect of Sodium Tungstate on Obesity Induced Cardiac Hypertrophy and
   Oxidative Stress
SO LATIN AMERICAN JOURNAL OF PHARMACY
LA English
DT Article
DE Obesity; Oxidative stress; Sodium tungstate
ID INTENTIONAL WEIGHT-LOSS; CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME;
   ADIPOSE-TISSUE; HEART-FAILURE; RATS; HYPERTENSION; PATHOPHYSIOLOGY;
   THERMOGENESIS; PROTEINS
AB Obesity was induced by high fat diet (30 % fat by weight). Wistar rats of 225-250 g were kept on high fat diet to induce obesity for 90 days. Sodium tungstate (2 mg/ml, in drinking water) was administered for 90 days. Obesity was assessed by measuring % age change in body weight, WHR ratio, adiposity index and obesity index. Left ventricular cardiac hypertrophy was assessed in terms of left ventricular weight, left ventricular wall thickness, left ventricular protein content and left ventricular collagen content. Oxidative stress was measured in terms of levels of thiobarbituric acid reactive substances (TBARS), superoxide anion generation (SAG) and level of reduced glutathione. Sodium tungstate significantly attenuated the increase in body weight adiposity index, obesity index, TBARS, SAG and reduced glutathione, whereas no significant change was observed the parameters of cardiac hypertrophy. So, it can be concluded that sodium tungstate significantly attenuated high fat diet induced obesity and oxidative stress but no significant decrease was observed in the parameters of cardiac hypertrophy.
C1 [Singh, Randhir; Singh, Manjeet; Krishan, Pawan] Punjabi Univ, Dept Pharmaceut Sci & Drug Res, Patiala 147002, Punjab, India.
C3 Punjabi University
RP Singh, R (corresponding author), Punjabi Univ, Dept Pharmaceut Sci & Drug Res, Patiala 147002, Punjab, India.
EM dahiya_rsd@rediffmail.com
RI Dahiya, Randhir/AAF-6424-2020; Krishan, Pawan/AAF-9983-2021
OI Singh, Randhir/0000-0003-0183-0797
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NR 39
TC 0
Z9 0
U1 0
U2 0
PU COLEGIO FARMACEUTICOS PROVINCIA DE BUENOS AIRES
PI LA PLATA
PA DEPT CIENTIFICO, CALLE 5 NO 966, LA PLATA, 00000, ARGENTINA
SN 0326-2383
J9 LAT AM J PHARM
JI Lat. Am. J. Pharm.
PD AUG
PY 2010
VL 29
IS 5
BP 747
EP 753
PG 7
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 654YW
UT WOS:000282208300016
DA 2025-06-11
ER

PT J
AU Yoshino, K
   Suzuki, S
   Ishizuka, Y
   Takayanagi, A
   Sugihara, N
   Kamijyo, H
AF Yoshino, Koichi
   Suzuki, Seitaro
   Ishizuka, Yoichi
   Takayanagi, Atsushi
   Sugihara, Naoki
   Kamijyo, Hideyuki
TI Relationship between job stress and subjective oral health symptoms in
   male financial workers in Japan
SO INDUSTRIAL HEALTH
LA English
DT Article
DE Oral health; Subjective symptoms; Job stress; BJSQ; Stress check
ID PERIODONTAL-DISEASE; METABOLIC SYNDROME; RISK-FACTORS
AB Objective: The aim was to assess subjective oral health symptoms and job stress, as measured by self-assessment of how demanding the job is, in male financial workers. Methods: The participants were recruited by applying screening procedures to a pool of Japanese registrants in an online database. For the stress check, 7 items about how demanding the job is were selected from The Brief Job Stress Questionnaire (BJSQ). Participants comprised a total of 950 financial male workers, ages 25 to 64. Results: Participants who answered "I can't complete my work in the required time" had more decayed teeth (p = 0.010). Participants who felt that their job is highly demanding (answered affirmatively to 6 or all 7 items) were more likely to report "often get food stuck between teeth" (p=0.030), "there are some foods I can't eat" (p=0.005), "bad breath" (p=0.032), and "jaw makes clicking sound" (p=0.032). The independent variable of total stress score of 24-28 was found to be correlated to at least three oral health symptoms (OR: 3.25; 95%CI: 1.66-6.35). Conclusion: These results indicate that certain job stress factors are associated with certain oral health symptoms, and that oral health symptoms are likely predictors of job stress.
C1 [Yoshino, Koichi; Suzuki, Seitaro; Ishizuka, Yoichi; Takayanagi, Atsushi; Sugihara, Naoki] Tokyo Dent Coll, Dept Epidemiol & Publ Hlth, Tokyo, Japan.
   [Kamijyo, Hideyuki] Tokyo Dent Coll, Dept Social Secur Dent, Tokyo, Japan.
C3 Tokyo Dental College; Tokyo Dental College
RP Yoshino, K (corresponding author), Tokyo Dent Coll, Dept Epidemiol & Publ Hlth, Tokyo, Japan.
EM ko-yoshi@d8.dion.ne.jp
RI Ishizuka, Yoichi/HPB-6409-2023
FU Research Fund for Clinical Study of Industrial Accidents and Diseases
   [140201-02]
FX This study was supported by the Research Fund for Clinical Study of
   Industrial Accidents and Diseases (140201-02).
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NR 31
TC 8
Z9 8
U1 0
U2 11
PU NATL INST OCCUPATIONAL SAFETY & HEALTH, JAPAN
PI KAWASAKI KANAGAWA
PA 21-1 NAGAO 6-CHOME TAMA-KU, KAWASAKI KANAGAWA, 214, JAPAN
SN 0019-8366
EI 1880-8026
J9 IND HEALTH
JI Ind. Health
PD MAR
PY 2017
VL 55
IS 2
BP 119
EP 126
DI 10.2486/indhealth.2016-0120
PG 8
WC Environmental Sciences; Public, Environmental & Occupational Health;
   Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health; Toxicology
GA EQ3XY
UT WOS:000398008500004
PM 27840370
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Mumford, EA
   Taylor, BG
   Kubu, B
AF Mumford, Elizabeth A.
   Taylor, Bruce G.
   Kubu, Bruce
TI Law Enforcement Officer Safety and Wellness
SO POLICE QUARTERLY
LA English
DT Article
DE law enforcement; occupational safety; officer health; critical
   incidents; PTSD
ID UNITED-STATES; METABOLIC SYNDROME; CARDIOVASCULAR-DISEASE;
   ALCOHOL-CONSUMPTION; CIGARETTE-SMOKING; POLICE OFFICERS; PTSD SYMPTOMS;
   SHIFT WORK; PART I; STRESS
AB Officers in law enforcement agencies (LEAs) experience long-term health morbidity and mortality at rates exceeding other occupations and the general population. The purpose of this study was to pilot a survey of officer safety and wellness to demonstrate feasibility, assess the need for further research, and lay the groundwork for policies and additional support for officer wellbeing. A random sample of 184 officers from 11 participating LEAs responded to a survey regarding physical activity patterns, job characteristics, substance use, critical incidents, job-related stress, personal health, and health-care usage. Officers reported physical health outcomes at rates similar to the general population but screened positive for elevated rates of posttraumatic stress disorder, common mental disorders, and alcohol misuse. These data support the need for research at the regional and national levels to inform LEA policies and programs.
C1 [Mumford, Elizabeth A.; Taylor, Bruce G.] Univ Chicago, NORC, Bethesda, MD 20814 USA.
   [Kubu, Bruce] Police Execut Res Forum, Washington, DC USA.
C3 University of Chicago
RP Mumford, EA (corresponding author), Univ Chicago, NORC, 4350 East West Highway,Suite 800, Bethesda, MD 20814 USA.
EM mumford-elizabeth@norc.org
OI Taylor, Bruce/0000-0002-8115-1438
FU NORC at the University of Chicago; Police Executive Research Forum
FX The authors disclosed receipt of the following financial support for the
   research, authorship, and/or publication of this article: NORC at the
   University of Chicago in collaboration with Police Executive Research
   Forum provided support for this study.
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NR 92
TC 40
Z9 75
U1 0
U2 34
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1098-6111
EI 1552-745X
J9 POLICE Q
JI Police Q.
PD JUN
PY 2015
VL 18
IS 2
BP 111
EP 133
DI 10.1177/1098611114559037
PG 23
WC Criminology & Penology
WE Social Science Citation Index (SSCI)
SC Criminology & Penology
GA CH8HZ
UT WOS:000354278500001
DA 2025-06-11
ER

PT J
AU de Lemos, ET
   Oliveira, J
   Pinheiro, JP
   Reis, F
AF de Lemos, Edite Teixeira
   Oliveira, Jorge
   Pinheiro, Joao Pascoa
   Reis, Flavio
TI Regular Physical Exercise as a Strategy to Improve Antioxidant and
   Anti-Inflammatory Status: Benefits in Type 2 Diabetes Mellitus
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Review
ID INDUCED OXIDATIVE STRESS; INDUCED WEIGHT-LOSS; INSULIN-RESISTANCE;
   REACTIVE OXYGEN; ENDOTHELIAL FUNCTION; NITRIC-OXIDE; URIC-ACID;
   DENSITY-LIPOPROTEIN; NAD(P)H OXIDASE; FREE-RADICALS
AB Over the last 30 years the combination of both a sedentary lifestyle and excessive food availability has led to a significant increase in the prevalence of obesity and aggravation of rates of metabolic syndrome and type 2 diabetes mellitus (T2DM). Several lines of scientific evidence have been demonstrating that a low level of physical activity and decreased daily energy expenditure leads to the accumulation of visceral fat and, consequently, the activation of the oxidative stress/inflammation cascade, which underlies the development of insulin resistant T2DM and evolution of micro, and macrovascular complications. This paper focuses on the pathophysiological pathways associated with the involvement of oxidative stress and inflammation in the development of T2DM and the impact of regular physical exercise (training) as a natural antioxidant and anti-inflammatory strategy to prevent evolution of T2DM and its serious complications.
C1 [de Lemos, Edite Teixeira; Reis, Flavio] Univ Coimbra, Fac Med, IBILI, Lab Pharmacol & Expt Therapeut, P-3000354 Coimbra, Portugal.
   [de Lemos, Edite Teixeira; Oliveira, Jorge] Polytech Inst Viseu, ESAV, P-3504510 Viseu, Portugal.
   [Oliveira, Jorge] Polytech Inst Viseu, Ctr Study Educ Technol & Hlth, P-3504510 Viseu, Portugal.
C3 Universidade de Coimbra; Instituto Politecnico de Viseu; Instituto
   Politecnico de Viseu
RP Reis, F (corresponding author), Univ Coimbra, Fac Med, IBILI, Lab Pharmacol & Expt Therapeut, P-3000354 Coimbra, Portugal.
EM freis@fmed.uc.pt
RI Reis, Flávio/E-7077-2016; Teixeira-Lemos, Edite/AAW-9401-2021; Oliveira,
   Jorge/C-6443-2014
OI Pascoa Pinheiro, Joao/0000-0001-8666-1819; Teixeira-Lemos,
   Edite/0000-0002-6346-8319; Oliveira, Jorge/0000-0002-9391-5191; Reis,
   Flavio/0000-0003-3401-9554
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NR 158
TC 101
Z9 106
U1 0
U2 38
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PY 2012
VL 2012
AR 741545
DI 10.1155/2012/741545
PG 15
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA 997RT
UT WOS:000308184500001
PM 22928086
OA Green Published, Green Submitted, hybrid
DA 2025-06-11
ER

PT J
AU Kokubun, K
AF Kokubun, Keisuke
TI Effort-Reward Imbalance and Passion Exploitation: A Narrative Review and
   a New Perspective
SO WORLD
LA English
DT Review
DE effort-reward imbalance; passion exploitation; intrinsic motivation;
   transformational leadership
ID CORONARY-HEART-DISEASE; WORK STRESS; MODEL; OVERCOMMITMENT;
   QUESTIONNAIRE; EMPOWERMENT; WORKPLACE
AB This paper provides a narrative review of previous research on effort-reward imbalance (ERI) and passion exploitation, providing a perspective for future research. Previous research has shown that ERI can cause work stress, negative economic behavior such as job turnover, and illnesses such as metabolic syndrome. Previous research also claims that loyal and generous people, as well as young people and women, are more likely to be targets of passion exploitation. However, there are unresolved issues in previous research, such as (i) the mechanism by which effort-reward imbalance leads to stress and illness, (ii) there being lack of research on what types of jobs are more likely to experience imbalance, and (iii) there being lack of research on what level of imbalance is acceptable, and therefore further research is required. To this end, this study recommends addressing these challenges through the integration of ERI and passion exploitation theory.
C1 [Kokubun, Keisuke] Kyoto Univ, Grad Sch Management, Kyoto 6068501, Japan.
C3 Kyoto University
RP Kokubun, K (corresponding author), Kyoto Univ, Grad Sch Management, Kyoto 6068501, Japan.
EM kokubun.keisuke.6x@kyoto-u.jp
RI Kokubun, Keisuke/H-9590-2018
OI Kokubun, Keisuke/0000-0002-7440-5049
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NR 79
TC 0
Z9 0
U1 2
U2 2
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2673-4060
J9 WORLD-BASEL
JI World
PD DEC
PY 2024
VL 5
IS 4
BP 1235
EP 1247
DI 10.3390/world5040063
PG 13
WC Economics; Political Science; Social Sciences, Interdisciplinary
WE Emerging Sources Citation Index (ESCI)
SC Business & Economics; Government & Law; Social Sciences - Other Topics
GA Q8K5U
UT WOS:001387099000001
OA gold
DA 2025-06-11
ER

PT J
AU Bhatti, S
   Kozlov, S
   Farooqi, AA
   Naqi, A
   Lavin, M
   Khanna, KK
AF Bhatti, Shahzad
   Kozlov, Sergei
   Farooqi, Ammad Ahmad
   Naqi, Ali
   Lavin, Martin
   Khanna, Kum Kum
TI ATM protein kinase: the linchpin of cellular defenses to stress
SO CELLULAR AND MOLECULAR LIFE SCIENCES
LA English
DT Review
DE ATM kinase; DNA damage response; Signaling; Carcinogenesis
ID DOUBLE-STRAND BREAKS; DNA-DAMAGE RESPONSE; TELANGIECTASIA MUTATED ATM;
   S-PHASE CHECKPOINT; ATAXIA-TELANGIECTASIA; IONIZING-RADIATION; OXIDATIVE
   STRESS; DEPENDENT PHOSPHORYLATION; MRE11/RAD50/NBS1 COMPLEX;
   INSULIN-RESISTANCE
AB ATM is the most significant molecule involved in monitoring the genomic integrity of the cell. Any damage done to DNA relentlessly challenges the cellular machinery involved in recognition, processing and repair of these insults. ATM kinase is activated early to detect and signal lesions in DNA, arrest the cell cycle, establish DNA repair signaling and faithfully restore the damaged chromatin. ATM activation plays an important role as a barrier to tumorigenesis, metabolic syndrome and neurodegeneration. Therefore, studies of ATM-dependent DNA damage signaling pathways hold promise for treatment of a variety of debilitating diseases through the development of new therapeutics capable of modulating cellular responses to stress. In this review, we have tried to untangle the complex web of ATM signaling pathways with the purpose of pinpointing multiple roles of ATM underlying the complex phenotypes observed in AT patients.
C1 [Kozlov, Sergei; Lavin, Martin; Khanna, Kum Kum] Queensland Inst Med Res, QIMR, Brisbane, Qld 4029, Australia.
   [Bhatti, Shahzad; Farooqi, Ammad Ahmad; Naqi, Ali] Univ Lahore, Inst Mol Biol & Biotechnol, Lahore, Pakistan.
C3 QIMR Berghofer Medical Research Institute; University of Lahore
RP Kozlov, S (corresponding author), Queensland Inst Med Res, QIMR, 300 Herston Rd, Brisbane, Qld 4029, Australia.
EM Sergei.Kozlov@qimr.edu.au
RI Kozlov, Sergei/T-9779-2019; Khanna, Kum/I-1747-2013; Farooqi,
   Ammad/O-9760-2018; Lavin, Martin/F-5961-2014
OI Farooqi, Ammad/0000-0003-2899-5014; Bhatti, Shahzad/0000-0003-1937-0100;
   Khanna, Kum Kum/0000-0001-8650-5381; Lavin, Martin/0000-0002-5940-4769
FU National Health and Medical Research Council (NHMRC); Australian
   Research Council (ARC); Cancer Council Queensland (CCQ)
FX We apologize to our colleagues whose data have not been cited due to
   space limitations. The support by grants from the National Health and
   Medical Research Council (NHMRC), Australian Research Council (ARC) and
   Cancer Council Queensland (CCQ) is gratefully appreciated. We are
   thankful to Madeleine Kersting for excellent graphic artwork
   preparation, Dr Kevin Spring for useful comments and the editor for
   inviting this review.
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NR 273
TC 89
Z9 101
U1 2
U2 22
PU SPRINGER BASEL AG
PI BASEL
PA PICASSOPLATZ 4, BASEL, 4052, SWITZERLAND
SN 1420-682X
EI 1420-9071
J9 CELL MOL LIFE SCI
JI Cell. Mol. Life Sci.
PD SEP
PY 2011
VL 68
IS 18
BP 2977
EP 3006
DI 10.1007/s00018-011-0683-9
PG 30
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA 811ZY
UT WOS:000294258700001
PM 21533982
OA Green Published
DA 2025-06-11
ER

PT J
AU Wang, LZ
   Li, WX
   Li, YG
   Chen, GR
   Zhao, LJ
   Li, W
   Wang, SW
   Wang, CM
   Feng, YX
   Zhang, YB
AF Wang, Lingzhi
   Li, Wenxi
   Li, Yinggang
   Chen, Gengrui
   Zhao, Lijuan
   Li, Wu
   Wang, Shengwei
   Wang, Chunming
   Feng, Yanxian
   Zhang, Yibo
TI Dried tangerine peel polysaccharide (DTPP) alleviates hepatic steatosis
   by suppressing TLR4/MD-2-mediated inflammation and endoplasmic reticulum
   stress
SO BIOORGANIC CHEMISTRY
LA English
DT Article
DE NAFLD; Dried tangerine peel polysaccharide; Inflammation; Endoplasmic
   reticulum stress; Zebrafish
ID RECEPTOR 4; ZEBRAFISH; TLR4; PATHOGENESIS; BINDING; ROLES; CELLS; MD-2;
   LPS
AB Non-alcoholic fatty liver disease (NAFLD) is a complex pathogenic metabolic syndrome characterized by increased inflammation and endoplasmic reticulum stress. In recent years, natural polysaccharides derived from traditional Chinese medicine have shown significant anti-inflammatory effects, making them an attractive therapeutic option. However, little research has been conducted on the therapeutic potential of dried tangerine peel polysaccharide (DTPP) - one of the most important medicinal resources in China. The results of the present study showed that DTPP substantially reduced macrophage infiltration in vivo and suppressed the expression of pro-inflammatory factors and endoplasmic reticulum stress-related genes. Additionally, surface plasmon resonance analysis revealed that DTPP had a specific affinity to myeloid differentiation factor 2, which consequently suppressed lipopolysaccharide-induced inflammation via interaction with the toll-like receptor 4 signaling pathway. This study provides a potential molecular mechanism underlying the anti-inflammatory effects of DTPP on NAFLD and suggests DTPP as a promising therapeutic strategy for NAFLD treatment.
C1 [Wang, Lingzhi; Li, Wenxi; Li, Yinggang; Chen, Gengrui; Zhao, Lijuan; Li, Wu; Wang, Shengwei; Feng, Yanxian] Wuyi Univ, Sch Pharm & Food Engn, Jiangmen 529020, Peoples R China.
   [Wang, Chunming] Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Taipa, Macau, Peoples R China.
   [Wang, Lingzhi; Zhang, Yibo] Jinan Univ, Coll Life Sci & Technol, Dept Cell Biol, State Key Lab Bioact Mol & Druggabil Assessment,Na, Guangzhou, Peoples R China.
   [Wang, Lingzhi; Zhang, Yibo] Jinan Univ, Inst Biomed, Coll Life Sci & Technol, State Key Lab Bioact Mol & Druggabil Assessment,Na, Guangzhou, Peoples R China.
C3 Wuyi University; University of Macau; Jinan University; Jinan University
RP Feng, YX (corresponding author), Wuyi Univ, Sch Pharm & Food Engn, Jiangmen 529020, Peoples R China.; Zhang, YB (corresponding author), Jinan Univ, Coll Life Sci & Technol, Dept Cell Biol, State Key Lab Bioact Mol & Druggabil Assessment,Na, Guangzhou, Peoples R China.; Zhang, YB (corresponding author), Jinan Univ, Inst Biomed, Coll Life Sci & Technol, State Key Lab Bioact Mol & Druggabil Assessment,Na, Guangzhou, Peoples R China.
EM yanxianfeng@wyu.edu.cn; zyb_87@hotmail.com
RI Zhao, Lijuan/E-8485-2012; Yanxian, Feng/ABC-1623-2021; Zhang,
   Bob/ABD-5926-2021
FU National Natural Science Foundation of China [32000936, 81902801];
   Guangdong Provincial Key Construction Discipline Research Ability
   Enhancement Project [2022ZDJS026]; Special projects in key areas of
   general colleges and universities in Guangdong Province [2023ZDZX2064];
   Guangdong Basic and Applied Basic Research Foundation [2024A1515030168];
   Wuyi University-Macau University Joint Research Foundation [2022WGALH10,
   2021WGALH13]
FX This work is supported by the National Natural Science Foundation of
   China (No.32000936 and 81902801) , Guangdong Provincial Key Construction
   Discipline Research Ability Enhancement Project (No.2022ZDJS026) , The
   Special projects in key areas of general colleges and universities in
   Guangdong Province (No. 2023ZDZX2064) , Guangdong Basic and Applied
   Basic Research Foundation (No.2024A1515030168) and Wuyi University-Macau
   University Joint Research Foundation (No.2022WGALH10 and 2021WGALH13) .
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NR 39
TC 4
Z9 5
U1 10
U2 32
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0045-2068
EI 1090-2120
J9 BIOORG CHEM
JI Bioorganic Chem.
PD JUN
PY 2024
VL 147
AR 107369
DI 10.1016/j.bioorg.2024.107369
EA APR 2024
PG 12
WC Biochemistry & Molecular Biology; Chemistry, Organic
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA C8D8I
UT WOS:001291628600001
PM 38640721
DA 2025-06-11
ER

PT J
AU Na, MK
   Jeong, YT
   Li, X
   Jin, F
   Hwang, SL
   Kim, GJ
   Yang, JH
   Chang, YC
   Kim, DS
   Kim, CH
   Chang, HW
AF Na, Min Kyun
   Jeong, Yong-Tae
   Li, Xian
   Jin, Fansi
   Hwang, Seung-Lark
   Kim, Geum Jin
   Yang, Ju Hye
   Chang, Young-Chae
   Kim, Dong Soo
   Kim, Cheorl-Ho
   Chang, Hyeun Wook
TI Protective effect of butanol extracts of skin of Anguilla
   japonica against endoplasmic reticulum stress-induced insulin
   resistance via the AMPK pathway in L6 myotubes
SO FOOD SCIENCE AND BIOTECHNOLOGY
LA English
DT Article
DE AMP-activated protein kinase; Anguilla japonica skin; Insulin
   resistance; L6 myotube
ID ACTIVATED PROTEIN-KINASE; METABOLIC SYNDROME; SKELETAL-MUSCLE; MOUSE
   MODEL; GLUCOSE; SENSITIVITY; HOMEOSTASIS; CASCADE; OBESITY; LECTIN
AB The effect of butanol extracts of the skin of Anguilla japonica (BESA) on endoplasmic reticulum (ER) stress-induced insulin resistance in L6 myotubes was investigated. Western blotting revealed that BESA increased phosphorylation of AMP-activated protein kinase (AMPK) and acetyl-CoA carboxylase, and stimulated glucose uptake in L6 myotubes. Stimulation of AMPK and glucose uptake by BESA were significantly (p < 0.05) reduced by siRNA LKB1 or siRNA AMPK, compared with controls, suggesting that enhanced glucose uptake by BESA was predominantly accomplished via an LKB1-mediated AMPK activation pathway. In addition, BESA effectively reduced phosphorylation of ER stress markers, RNA-activated protein kinase-like ER resident kinase, JNK, and significantly (p < 0.01) increased glucose uptake via AMPK activation in tunicamycin-treated L6 myotubes, compared with controls. Improvement of insulin sensitivity under ER stress conditions by BESA is predominantly accomplished via an LKB1-AMPK-dependent pathway.
C1 [Na, Min Kyun] Chungnam Natl Univ, Coll Pharm, Taejon 305764, South Korea.
   [Jeong, Yong-Tae; Li, Xian; Jin, Fansi; Hwang, Seung-Lark; Kim, Geum Jin; Chang, Hyeun Wook] Yeungnam Univ, Coll Pharm, Gyongsan 712749, Gyeongbuk, South Korea.
   [Yang, Ju Hye] Korea Inst Oriental Med, Korea Med Based Herbal Drug Dev Grp, Taejon 305811, South Korea.
   [Chang, Young-Chae] Catholic Univ Daegu, Sch Med, Dept Pathol, Daegu 705718, South Korea.
   [Kim, Dong Soo] Kyung Sung Univ, Dept Food Sci & Biotechnol, Busan 608736, South Korea.
   [Kim, Cheorl-Ho] Sungkyunkwan Univ, Dept Biol Sci, Suwon 440746, Gyeonggi, South Korea.
C3 Chungnam National University; Yeungnam University; Korea Institute of
   Oriental Medicine (KIOM); Catholic University of Daegu; Sungkyunkwan
   University (SKKU)
RP Chang, HW (corresponding author), Yeungnam Univ, Coll Pharm, Gyongsan 712749, Gyeongbuk, South Korea.
EM hwchang@yu.ac.kr
RI Yang, Ju-Hye/GNH-6607-2022; Kim, Cheorl-Ho/T-6753-2019; na,
   ma/K-4873-2013
OI Na, MinKyun/0000-0002-4865-6506; Kim, Cheorl-Ho/0000-0002-6323-0714
FU Fisheries Technology Development Program - Ministry for Food,
   Agriculture, Forestry, and Fisheries of the Korean government; National
   Research Foundation of Korea - Korean Government (MEST)
   [NRF-2010-0020484]
FX This research was supported by the Fisheries Technology Development
   Program funded by the Ministry for Food, Agriculture, Forestry, and
   Fisheries of the Korean government and, in part, supported by a National
   Research Foundation of Korea Grant funded by the Korean Government
   (MEST) (NRF-2010-0020484).
CR Carling D, 2004, TRENDS BIOCHEM SCI, V29, P18, DOI 10.1016/j.tibs.2003.11.005
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NR 25
TC 0
Z9 0
U1 0
U2 10
PU KOREAN SOCIETY FOOD SCIENCE & TECHNOLOGY-KOSFOST
PI SEOUL
PA #605, KOREA SCI TECHNOL CENT, 635-4 YEOKSAM-DONG, KANGNAM-GU, SEOUL,
   135-703, SOUTH KOREA
SN 1226-7708
EI 2092-6456
J9 FOOD SCI BIOTECHNOL
JI Food Sci. Biotechnol.
PD JUN
PY 2015
VL 24
IS 3
BP 1069
EP 1075
DI 10.1007/s10068-015-0137-5
PG 7
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA CI6QR
UT WOS:000354886300037
DA 2025-06-11
ER

PT J
AU Kwon, AR
   Yoon, YS
   Min, KP
   Lee, YK
   Jeon, JH
AF Kwon, A. Rom
   Yoon, Yeong Sook
   Min, Kyong Pil
   Lee, Yoon Kyung
   Jeon, Ji Ho
TI Eating alone and metabolic syndrome: A population-based Korean National
   Health and Nutrition Examination Survey 2013-2014
SO OBESITY RESEARCH & CLINICAL PRACTICE
LA English
DT Article
DE Eating alone; Commensality; Living alone; Abdominal obesity; Metabolic
   syndrome
ID SCIENTIFIC STATEMENT; PHYSICAL-ACTIVITY; ASSOCIATION; OBESITY; ADULTS;
   FOOD; BEHAVIORS; QUESTIONNAIRE; DEPRESSION; VALIDITY
AB Eating alone has been an emerging social concern in modern life. However, there is little research on the association between eating alone and Metabolic syndrome (MetS).
   We aimed to assess the association between eating alone and the MetS and to identify whether sociodemographic factors modify this association.
   This study included 7725 adults (>= 19 years} who participated in the Korean National Health and Nutrition Examination Survey (KNHANES) 2013-2014. Multivariable logistic regression analysis was used for assessing the association of eating alone (none, 1 time/day, and >= 2 times/day) with MetS.
   The percentages of subjects with MetS were 30.4% in men and 24.2% in women. 20.8% of men and 29.2% of women ate alone >= 2 times/day. Individuals who ate alone 2 or more times per day showed higher frequency of living alone, having no spouse, skip meals, and less eating out (p < 0.05). Women with eating alone >= 2 times/day had a crude OR of 1.29 (95% Cl:1.08-1.53, p-trend = 0.001) for MetS compared with women without eating alone. However, this association was no longer significant after adjustments for confounding factors. Eating alone >= 2 times/day was significantly associated with increase abdominal obesity (OR, 95% Cl: 1.45, 1.10-1.91, p-trend = 0.039) and MetS (1.64, 1.28-2.10, p-trend-0.004) in men. Eating alone was associated with a higher likelihood of having a MetS in men without spouse as compared with those with spouse (OR for men without spouse 3.02, 95% CI: 1.50-6.11 and OR for men with spouse 1.48, 95% CI: 1.22-1.7, p-interaction = 0.027).
   Our results indicate that eating alone may be a potential risk factor for MetS. (C) 2017 Asia Oceania Association for the Study of Obesity. Published by Elsevier Ltd. All rights reserved.
C1 [Kwon, A. Rom; Lee, Yoon Kyung; Jeon, Ji Ho] Dongguk Univ, Smart Healthcare Ctr, Ilsan Hosp, 27 Dongguk Ro, Goyang Si 10326, Gyeonggi Do, South Korea.
   [Yoon, Yeong Sook] Inje Univ, Dept Family Med, Ilsan Paik Hosp, 170 Juhwa Ro, Goyang Si 10380, Gyeonggi Do, South Korea.
   [Min, Kyong Pil] HurayPositive Inc, 69,Nonhyeon Ro 149 Gil, Seoul 06039, South Korea.
C3 Dongguk University; NHIS Ilsan Hospital; Inje University
RP Yoon, YS (corresponding author), Inje Univ, Dept Family Med, Ilsan Paik Hosp, 170 Juhwa Ro, Goyang Si 10380, Gyeonggi Do, South Korea.
EM sweet6531@naver.com; ysyoon@paik.ac.kr; kpmin@huray.net;
   lorain0331@nate.com; jihojeon744@naver.com
OI Yoon, Yeong Sook/0000-0002-9249-2940
FU Residential Environment Research Program - Ministry of Land,
   Infrastructure and Transport of Korean government [17RERP-B090228-04]
FX This research was supported by a grant (17RERP-B090228-04) from
   Residential Environment Research Program funded by Ministry of Land,
   Infrastructure and Transport of Korean government.
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NR 37
TC 34
Z9 36
U1 0
U2 7
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1871-403X
EI 1878-0318
J9 OBES RES CLIN PRACT
JI Obes. Res. Clin. Pract.
PD MAR-APR
PY 2018
VL 12
IS 2
BP 146
EP 157
DI 10.1016/j.orcp.2017.09.002
PG 12
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA GG1LJ
UT WOS:000432448200003
PM 29066025
DA 2025-06-11
ER

PT J
AU Decorde, K
   Teissedre, PL
   Sutra, T
   Ventura, E
   Cristol, JP
   Rouanet, JM
AF Decorde, Kelly
   Teissedre, Pierre-Louis
   Sutra, Thibault
   Ventura, Emilie
   Cristol, Jean-Paul
   Rouanet, Jean-Max
TI Chardonnay grape seed procyanidins prevent obesity in hamsters
SO AGRO FOOD INDUSTRY HI-TECH
LA English
DT Article
DE obesity; adipocytokines; oxidative stress; grape seed proanthocyanidins;
   hamsters
ID SYSTEMIC OXIDATIVE STRESS; DIET-INDUCED OBESITY; FAT ACCUMULATION;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; GLUCOSE LEVEL; OXIDASE; RODENTS;
   MICE; ABSORPTION
AB We analyzed the effects of a phenolic grape seed extract (GSE) on obesity and oxidative stress in hamsters receiving a high-fat diet (HF). Hamsters received a HF diet plus a daily gavage with water (Control, HF) or a solution of GSE (HF+GSE), for 12 weeks. HF diet increased abdominal fat. GSE avoided this feature. HF diet led to higher plasma glucose, triglycerides, insulin and insulin resistance values. GSE prevented in part these effects, reducing insulinemia and leptinemia by 16.5 percent an 45 percent respectively, whereas adiponectin level increased by 61 percent compared with obese controls. GSE lowered glycemic and insulin resistance and strongly prevented cardiac NAD(P)H oxidase activity (74 percent) and expression (30 percent). For the first time the chronic consumption of grape seed tannins has potential effects against the development of obesity.
C1 [Decorde, Kelly; Sutra, Thibault; Ventura, Emilie; Cristol, Jean-Paul; Rouanet, Jean-Max] Univ Montpellier Sud France, UMR Prevent Malnutr & Pathol Associees 204, Montpellier, France.
   [Teissedre, Pierre-Louis] Univ Bordeaux 2, INRA, Fac Oenol, UMR Oenol 1219, Talence, France.
C3 Institut de Recherche pour le Developpement (IRD); Universite de
   Montpellier; INRAE; Universite de Bordeaux
RP Rouanet, JM (corresponding author), Univ Montpellier Sud France, UMR Prevent Malnutr & Pathol Associees 204, Montpellier, France.
RI Teissedre, Pierre-Louis/I-6885-2016
OI TEISSEDRE, Pierre-Louis/0000-0002-0115-5456
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   Nagao T, 2007, OBESITY, V15, P1473, DOI 10.1038/oby.2007.176
   Nakagawa K, 2004, BIOL PHARM BULL, V27, P1775, DOI 10.1248/bpb.27.1775
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NR 25
TC 1
Z9 3
U1 0
U2 8
PU TEKNOSCIENZE PUBL
PI MILANO
PA VIALE BRIANZA 22, 20127 MILANO, ITALY
SN 1722-6996
EI 2035-4606
J9 AGRO FOOD IND HI TEC
JI Agro Food Ind. Hi-Tech
PD NOV-DEC
PY 2009
VL 20
IS 6
BP 22
EP 24
PG 3
WC Biotechnology & Applied Microbiology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Food Science & Technology
GA 548PG
UT WOS:000273978100005
DA 2025-06-11
ER

PT J
AU Wang, JW
   Wan, XY
   Zhu, HT
   Lu, C
   Yu, WL
   Yu, CH
   Shen, Z
   Li, YM
AF Wang, Jie-wei
   Wan, Xing-yong
   Zhu, Hua-tuo
   Lu, Chao
   Yu, Wei-lai
   Yu, Chao-hui
   Shen, Zhe
   Li, You-ming
TI Lipotoxic Effect of p21 on Free Fatty Acid-Induced Steatosis in L02
   Cells
SO PLOS ONE
LA English
DT Article
ID LIVER-DISEASE; NONALCOHOLIC STEATOHEPATITIS; PROTEASOME INHIBITOR;
   OXIDATIVE STRESS; PROGRESSION; MICE; SENESCENCE; REGENERATION;
   PATHOGENESIS; HEPATOCYTES
AB Nonalcoholic fatty liver disease (NAFLD) is increasingly regarded as a hepatic manifestation of metabolic syndrome. Though with high prevalence, the mechanism is poorly understood. This study aimed to investigate the effects of p21 on free fatty acid (FFA)-induced steatosis in L02 cells. We therefore analyzed the L02 cells with MG132 and siRNA treatment for different expression of p21 related to lipid accumulation and lipotoxicity. Cellular total lipid was stained by Oil Red O, while triglyceride content, cytotoxicity assays, lipid peroxidation markers and anti-oxidation levels were measured by enzymatic kits. Treatment with 1 mM FFA for 48 hr induced magnificent intracellular lipid accumulation and increased oxidative stress in p21 overload L02 cells compared to that in p21 knockdown L02 cells. By increasing oxidative stress and peroxidation, p21 accelerates FFA-induced lipotoxic effect in L02 cells and might provide information about potentially new targets for drug development and treatments of NAFLD.
C1 [Wang, Jie-wei; Wan, Xing-yong; Zhu, Hua-tuo; Lu, Chao; Yu, Wei-lai; Yu, Chao-hui; Shen, Zhe; Li, You-ming] Zhejiang Univ, Coll Med, Affiliated Hosp 1, Dept Gastroenterol, Hangzhou 310003, Zhejiang, Peoples R China.
C3 Zhejiang University
RP Li, YM (corresponding author), Zhejiang Univ, Coll Med, Affiliated Hosp 1, Dept Gastroenterol, Hangzhou 310003, Zhejiang, Peoples R China.
EM zlym@zju.edu.cn
OI Ma, Han/0000-0001-9985-3035
FU National Natural Science Foundation of China [81270487, 81300303]
FX National Natural Science Foundation of China Grant number: 81270487,
   81300303 (http://www.nsfc.gov.cn/publish/portal0/default.htm). The
   funders had no role in study design, data collection and analysis,
   decision to publish, or preparation of the manuscript.
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   Zhang X, 2011, AM J PHYSIOL-GASTR L, V302, P558
NR 33
TC 4
Z9 5
U1 0
U2 17
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD APR 30
PY 2014
VL 9
IS 4
AR e96124
DI 10.1371/journal.pone.0096124
PG 8
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA AL1WP
UT WOS:000338917300027
PM 24788149
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Craft, S
   Foster, TC
   Landfield, PW
   Maier, SF
   Resnick, SM
   Yaffe, K
AF Craft, Suzanne
   Foster, Thomas C.
   Landfield, Philip W.
   Maier, Steven F.
   Resnick, Susan M.
   Yaffe, Kristine
TI Session III: Mechanisms of Age-Related Cognitive Change and Targets for
   Intervention: Inflammatory, Oxidative, and Metabolic Processes
SO JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL
   SCIENCES
LA English
DT Article
DE Aging; Cognition; Inflammation; Oxidative stress; Metabolism
ID ALZHEIMER-DISEASE; IMPAIRMENT; DECLINE; MEMORY; RISK; HIPPOCAMPUS;
   PREVALENCE; DEMENTIA; LATINOS; PROTEIN
AB There is increasing evidence from basic science and human epidemiological studies that inflammation, oxidative stress, and metabolic abnormalities are associated with age-related cognitive decline and impairment. This article summarizes selected research on these topics presented at the Cognitive Aging Summit II. Speakers in this session presented evidence highlighting the roles of these processes and pathways on age-related cognitive decline, pointing to possible targets for intervention in nondemented older adults. Specific areas discussed included age differences in the production of cytokines following injury or infection, mechanisms underlying oxidative stress-induced changes in memory consolidation, insulin effects on brain signaling and memory, and the association between metabolic syndrome and cognitive decline in older adults. These presentations emphasize advances in our understanding of mechanisms and modifiers of age-related cognitive decline and provide insights into potential targets to promote cognitive health in older adults.
C1 [Resnick, Susan M.] NIA, Lab Behav Neurosci, BRC, Baltimore, MD 21224 USA.
   [Craft, Suzanne] Univ Washington, Dept Psychiat & Behav Sci, Geriatr Res Educ & Clin Ctr, Seattle, WA 98195 USA.
   [Foster, Thomas C.] Univ Florida, Dept Neurosci, Evelyn F & William L McKnight Brain Inst, Gainesville, FL 32610 USA.
   [Landfield, Philip W.] Univ Kentucky, Dept Mol & Biomed Pharmacol, Coll Med, Lexington, KY 40506 USA.
   [Maier, Steven F.] Univ Colorado, Dept Psychol, Boulder, CO 80309 USA.
   [Maier, Steven F.] Univ Colorado, Dept Neurosci, Boulder, CO 80309 USA.
   [Yaffe, Kristine] Univ Calif San Francisco, Dept Psychiat, San Francisco, CA USA.
   [Yaffe, Kristine] Univ Calif San Francisco, Dept Neurol, San Francisco, CA USA.
   [Yaffe, Kristine] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA.
   [Yaffe, Kristine] San Francisco VA Med Ctr, San Francisco, CA USA.
C3 National Institutes of Health (NIH) - USA; NIH National Institute on
   Aging (NIA); Geriatric Research Education & Clinical Center; University
   of Washington; University of Washington Seattle; State University System
   of Florida; University of Florida; University of Kentucky; University of
   Colorado System; University of Colorado Boulder; University of Colorado
   System; University of Colorado Boulder; University of California System;
   University of California San Francisco; University of California System;
   University of California San Francisco; University of California System;
   University of California San Francisco; US Department of Veterans
   Affairs; Veterans Health Administration (VHA); San Francisco VA Medical
   Center
RP Resnick, SM (corresponding author), NIA, Lab Behav Neurosci, BRC, Room 4B335,251 Bayview Blvd, Baltimore, MD 21224 USA.
EM susan.resnick@nih.gov
RI Yaffe, Kristine/LLL-8209-2024
FU NCATS NIH HHS [UL1 TR000064] Funding Source: Medline; NIA NIH HHS [R37
   AG036800, R01 AG014979, R01 AG034605, P30 AG028740] Funding Source:
   Medline; Intramural NIH HHS [ZIA AG000191] Funding Source: Medline
CR [Anonymous], JAMA
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   Gu YA, 2010, ARCH NEUROL-CHICAGO, V67, P699, DOI 10.1001/archneurol.2010.84
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   Yaffe K, 2007, J AM GERIATR SOC, V55, P758, DOI 10.1111/j.1532-5415.2007.01139.x
   Yaffe K, 2009, ARCH NEUROL-CHICAGO, V66, P324, DOI 10.1001/archneurol.2008.566
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   Zhao WQ, 2009, BBA-MOL BASIS DIS, V1792, P482, DOI 10.1016/j.bbadis.2008.10.014
NR 26
TC 49
Z9 52
U1 0
U2 14
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1079-5006
J9 J GERONTOL A-BIOL
JI J. Gerontol. Ser. A-Biol. Sci. Med. Sci.
PD JUL
PY 2012
VL 67
IS 7
BP 754
EP 759
DI 10.1093/gerona/gls112
PG 6
WC Geriatrics & Gerontology; Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA 970PD
UT WOS:000306143700008
PM 22570133
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Kim, IG
   So, WY
   Sung, DJ
AF Kim, Ill-Gwang
   So, Wi-Young
   Sung, Dong Jun
TI The relationships between lifestyle factors and hypertension in
   community-dwelling Korean adults
SO JOURNAL OF PHYSICAL THERAPY SCIENCE
LA English
DT Article
DE Hypertension; Lifestyle factors
ID BLOOD-PRESSURE; ARTERIAL-HYPERTENSION; METABOLIC SYNDROME; POPULATION;
   PREVENTION; PREVALENCE; STRESS; WOMEN; RACE; MEN
AB [Purpose] This study was performed to determine whether certain lifestyle factors are associated with hypertension in community-dwelling Korean adults. [Subjects and Methods] The subjects were 586 males and 1,135 females >20 years old who had visited a public health promotion center in Seoul, Republic of Korea to take a survey related to lifestyle factors. Hypertension status was defined according to the criteria of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure VII report. [Results] The relationships between lifestyle factors and hypertension status were assessed using multivariate logistic regression analysis after adjusting for age and gender. Only mental stress and economic status significantly predicted hypertension status. [Conclusion] We conclude that sleep duration, education level, frequency of drinking and smoking status were not associated with hypertension status. However, economic status and mental stress were significantly associated with hypertension in community-dwelling Korean adults, regardless of age or gender.
C1 [Kim, Ill-Gwang] Seowon Univ, Sch Human Serv, Dept Leisure Sport, Cheongju, South Korea.
   [So, Wi-Young] Korea Natl Univ Transportat, Coll Human & Arts, Sports & Hlth Care Major, Seoul, South Korea.
   [Sung, Dong Jun] Konkuk Univ, Coll Sci & Technol, Div Sport Sci, 268 Chungwon Daero, Chungju Si 380701, Chungcheongbuk, South Korea.
C3 Seowon University; Korea National University of Transportation; Konkuk
   University
RP Sung, DJ (corresponding author), Konkuk Univ, Coll Sci & Technol, Div Sport Sci, 268 Chungwon Daero, Chungju Si 380701, Chungcheongbuk, South Korea.
EM sls98@kku.ac.kr
OI So, Wi-Young/0000-0002-9322-5852
CR Bae JM, 2002, J KOREAN MED SCI, V17, P328, DOI 10.3346/jkms.2002.17.3.328
   Davis MM, 2002, SEMIN NEPHROL, V22, P35, DOI 10.1053/snep.2002.28642
   de Morais PK, 2015, J PHYS THER SCI, V27, P51, DOI 10.1589/jpts.27.51
   Dickey R A, 2001, Endocr Pract, V7, P392
   Esler M, 2008, CLIN EXP PHARMACOL P, V35, P498, DOI 10.1111/j.1440-1681.2008.04904.x
   Gabler NB, 2012, CHEST, V141, P20, DOI 10.1378/chest.11-0404
   Ham OK, 2011, ASIA-PAC J PUBLIC HE, V23, P485, DOI 10.1177/1010539509347941
   Hur S, 2014, J PHYS THER SCI, V26, P1367, DOI 10.1589/jpts.26.1367
   Lynn S.Bickley, 2013, BATES GUIDE PHYS EXA
   Lyra R, 2012, REV ASSOC MED BRAS, V58, P209, DOI 10.1590/S0104-42302012000200017
   McGrane MM, 2011, CURR CARDIOVASC RISK, V5, P287, DOI 10.1007/s12170-011-0181-5
   National High Blood Pressure Education Program, 2003, JNC7 NAT HIGH BLOOD
   Slama M, 2002, CURR OPIN CARDIOL, V17, P531, DOI 10.1097/00001573-200209000-00014
   Sull JW, 2010, STROKE, V41, P2157, DOI 10.1161/STROKEAHA.110.586347
   Svetkey LP, 2005, J HUM HYPERTENS, V19, P21, DOI 10.1038/sj.jhh.1001770
   Talukder MAH, 2011, AM J PHYSIOL-HEART C, V300, pH388, DOI 10.1152/ajpheart.00868.2010
   Weir M.R., 2005, HYPERTENSION
   Wu MC, 2012, PREV MED, V55, P305, DOI 10.1016/j.ypmed.2012.07.013
NR 18
TC 7
Z9 8
U1 0
U2 2
PU SOC PHYSICAL THERAPY SCIENCE
PI TOKYO
PA C/O PUBLICATION CENTER, 1-24-12 SUGAMO, TOSHIMA-KU, TOKYO, 170-0002,
   JAPAN
SN 0915-5287
EI 2187-5626
J9 J PHYS THER SCI
JI J. Phys. Ther. Sci.
PD DEC
PY 2015
VL 27
IS 12
BP 3689
EP 3692
DI 10.1589/jpts.27.3689
PG 4
WC Rehabilitation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Rehabilitation
GA DB6EF
UT WOS:000368605500018
PM 26834333
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Changchien, TC
   Yen, YC
   Lin, CL
   Lin, MC
   Liang, JA
   Kao, CH
AF Changchien, Te-Chang
   Yen, Yung-Chieh
   Lin, Cheng-Li
   Lin, Ming-Chia
   Liang, Ji-An
   Kao, Chia-Hung
TI High Risk of Depressive Disorders in Patients With Gout A Nationwide
   Population-Based Cohort Study
SO MEDICINE
LA English
DT Article
ID MAGNETIC-RESONANCE-SPECTROSCOPY; METABOLIC SYNDROME; BIPOLAR DISORDER;
   CONTROLLED-TRIAL; MOOD DISORDERS; DOUBLE-BLIND; MANIA; SCHIZOPHRENIA;
   ALLOPURINOL; PLACEBO
AB Metabolic abnormalities are common in patients with depressive disorders. However, the relationship between gout and depression is unclear. We explored the causal relationship among gout, antigout medication, and the associated risk of incidental depressive disorders.
   In this nationwide cohort study, we sampled data from the National Health Insurance Research Database to recruit 34,050 patients with gout as the gout cohort and 68,100 controls (without gout) as the nongout cohort. Our primary endpoint was the diagnosis of depressive disorders during follow-up. The overall study population was followed up until depression diagnosis, withdrawal from the NHI program, or the end of the study. The differences in demographic and clinical characteristics between both cohorts were determined using the Chi-square test for categorical variables and the t-test for continuous variables. Cox proportional hazard regression models were used to examine the effect of gout on the risk of depression, represented using the hazard ratio with the 95% confidence interval.
   Patients with gout exhibited a higher risk of depressive disorders than controls did. The risk of depressive disorders increased with age and was higher in female patients and those with hypertension, stroke, and coronary artery disease. Nonsteroidal antiinflammatory drug and prednisolone use was associated with a reduced risk of depression. Patients with gout who had received antigout medication exhibited a reduced risk of depressive disorders compared with nongout patients.
   Our findings support that gout increases the risk of depressive disorders, and that antigout medication use reduces the risk.
C1 [Changchien, Te-Chang; Yen, Yung-Chieh] E Da Hosp, Dept Psychiat, Kaohsiung, Taiwan.
   [Changchien, Te-Chang; Yen, Yung-Chieh] I Shou Univ, Sch Med, Kaohsiung, Taiwan.
   [Lin, Cheng-Li] China Med Univ Hosp, Management Off Hlth Data, Taichung, Taiwan.
   [Lin, Cheng-Li] China Med Univ, Coll Med, Taichung 40447, Taiwan.
   [Lin, Ming-Chia] I Shou Univ, Dept Nucl Med, Kaohsiung, Taiwan.
   [Liang, Ji-An; Kao, Chia-Hung] China Med Univ, Grad Inst Clin Med Sci, Coll Med, Taichung 40447, Taiwan.
   [Liang, Ji-An; Kao, Chia-Hung] China Med Univ, Sch Med, Coll Med, Taichung 40447, Taiwan.
   [Liang, Ji-An] China Med Univ Hosp, Dept Radiat Oncol, Taichung, Taiwan.
   [Kao, Chia-Hung] China Med Univ Hosp, Dept Nucl Med, Taichung, Taiwan.
   [Kao, Chia-Hung] China Med Univ Hosp, PET Ctr, Taichung, Taiwan.
C3 E-Da Hospital; I Shou University; China Medical University Taiwan; China
   Medical University Hospital - Taiwan; China Medical University Taiwan; I
   Shou University; China Medical University Taiwan; China Medical
   University Taiwan; China Medical University Taiwan; China Medical
   University Hospital - Taiwan; China Medical University Taiwan; China
   Medical University Hospital - Taiwan; China Medical University Taiwan;
   China Medical University Hospital - Taiwan
RP Kao, CH (corresponding author), China Med Univ, Grad Inst Clin Med Sci, Coll Med, 2 Yuh Der Rd, Taichung 40447, Taiwan.
EM d10040@mail.cmuh.org.tw
RI liang, jian/HNI-8846-2023; Liao, Yu-Chi/AAT-1357-2021; , TC
   Changchien/LGZ-0295-2024
OI Lin, Cheng-Li/0000-0001-9926-3668; , TC Changchien/0009-0009-3120-7569
FU Taiwan Ministry of Health and Welfare Clinical Trial and Research Center
   of Excellence [MOHW104-TDU-B-212-113002]; China Medical University
   Hospital, Academia Sinica Taiwan Biobank, Stroke Biosignature Project
   [BM104010092]; NRPB Stroke Clinical Trial Consortium [MOST
   103-2325-B-039-006]; Tseng-Lien Lin Foundation, Taichung, Taiwan; Taiwan
   Brain Disease Foundation, Taipei, Taiwan; Katsuzo and Kiyo Aoshima
   Memorial Funds, Japan; CMU under the Aim for Top University Plan of the
   Ministry of Education, Taiwan
FX This study is supported in part by Taiwan Ministry of Health and Welfare
   Clinical Trial and Research Center of Excellence
   (MOHW104-TDU-B-212-113002); China Medical University Hospital, Academia
   Sinica Taiwan Biobank, Stroke Biosignature Project (BM104010092); NRPB
   Stroke Clinical Trial Consortium (MOST 103-2325-B-039-006); Tseng-Lien
   Lin Foundation, Taichung, Taiwan; Taiwan Brain Disease Foundation,
   Taipei, Taiwan; Katsuzo and Kiyo Aoshima Memorial Funds, Japan; and CMU
   under the Aim for Top University Plan of the Ministry of Education,
   Taiwan.
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NR 35
TC 19
Z9 20
U1 1
U2 15
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD DEC
PY 2015
VL 94
IS 52
AR e2401
DI 10.1097/MD.0000000000002401
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA DD3XM
UT WOS:000369856700044
PM 26717394
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Toraldo, DM
   De Nuccio, F
   De Benedetto, M
   Scoditti, E
AF Toraldo, D. M.
   De Nuccio, F.
   De Benedetto, M.
   Scoditti, E.
TI Obstructive sleep apnoea syndrome: a new paradigm by chronic nocturnal
   intermittent hypoxia and sleep disruption
SO ACTA OTORHINOLARYNGOLOGICA ITALICA
LA English
DT Review
DE Atherosclerosis; Cancer; Chronic intermittent hypoxia; Obstructive sleep
   apnoea; Sleep disruption
ID POSITIVE AIRWAY PRESSURE; PLASMINOGEN-ACTIVATOR INHIBITOR-1;
   CARDIOVASCULAR RISK-FACTORS; OXIDATIVE STRESS; PLATELET ACTIVATION;
   BLOOD-VISCOSITY; FOLLOW-UP; MORTALITY; COAGULABILITY; ASSOCIATION
AB Obstructive sleep apnoea syndrome (OSAS) is associated with severe cerebro-cardiovascular morbidity and mortality. It is an independent risk factor for atherosclerosis, arterial thrombosis and metabolic syndrome, and recently has been associated with an increased incidence of cancer and death. A causal link between OSAS and atherosclerosis has been partially established. Recent research on atherosclerosis in OSAS has focused on thrombotic tendency and blood viscosity, providing new insight into disease mechanisms. Hypoxia is a critical pathophysiological element in OSAS that leads to intensive sympathetic activity, in association with inflammation, oxidative stress and procoagulant activity. Hypoxia and the induction of oxidative stress can simultaneously represent an underlying mechanism in the pathogenesis of cancer development and progression. This mini-review will discuss the latest findings on the association and potential relationship between OSA and pathological vascular sequelae.
C1 [Toraldo, D. M.] ASL Lecce, V Fazzi Hosp, Rehabil Dept, Resp Care Unit, Lecce, Italy.
   [De Nuccio, F.] Univ Salento, Dept Biol & Environm Sci & Technol, Lab Human Anat & Neurosci, Lecce, Italy.
   [De Benedetto, M.] ASL Lecce, ENT Unit, V Fazzi Hosp, Lecce, Italy.
   [Scoditti, E.] CNR, Inst Clin Physiol, Lecce, Italy.
C3 University of Salento; Consiglio Nazionale delle Ricerche (CNR);
   Istituto di Fisiologia Clinica (IFC-CNR)
RP Toraldo, DM (corresponding author), Via AC Casetti 2, I-73100 Lecce, Italy.
EM d.torald@tin.it
RI De Nuccio, Francesco/GSD-5516-2022; SCODITTI, EGERIA/J-8609-2016
OI TORALDO, Domenico Maurizio/0000-0003-0023-0212; SCODITTI,
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NR 57
TC 27
Z9 29
U1 0
U2 15
PU PACINI EDITORE
PI PISA
PA VIA DELLA GHERARDESCA-ZONA INDUSTRIALE OSPEDALETTO, 56121 PISA, ITALY
SN 0392-100X
EI 1827-675X
J9 ACTA OTORHINOLARYNGO
JI Acta Otorhinolaryngol. Ital.
PD APR
PY 2015
VL 35
IS 2
BP 69
EP 74
PG 6
WC Otorhinolaryngology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Otorhinolaryngology
GA CJ2MI
UT WOS:000355318500001
PM 26019388
DA 2025-06-11
ER

PT J
AU Falkner, B
   Gidding, SS
   Baker-Smith, CM
   Brady, TM
   Flynn, JT
   Malle, LM
   South, AM
   Tran, AH
   Urbina, EM
AF Falkner, Bonita
   Gidding, Samuel S.
   Baker-Smith, Carissa M.
   Brady, Tammy M.
   Flynn, Joseph T.
   Malle, Leslie M.
   South, Andrew M.
   Tran, Andrew H.
   Urbina, Elaine M.
CA Amer Heart Assoc Council Hypertens
   Council Lifelong Congenital Heart
   Council Kidney Cardiovasc Dis
   Council Lifestyle Cardiometab Hlth
   Council Cardiovasc Stroke Nursing
TI Pediatric Primary Hypertension: An Underrecognized Condition: A
   Scientific Statement From the American Heart Association
SO HYPERTENSION
LA English
DT Article
DE AHA Scientific Statements; blood pressure; cardiovascular diseases;
   child; hypertension; obesity
ID HIGH BLOOD-PRESSURE; CARDIOMETABOLIC RISK-FACTORS; PHYSICAL-ACTIVITY;
   EUROPEAN-SOCIETY; CHILDREN; CHILDHOOD; ADULTHOOD; OBESITY; TRAJECTORIES;
   GUIDELINES
AB The overall prevalence of hypertension in childhood is 2% to 5%, and the leading type of childhood hypertension is primary hypertension, especially in adolescence. As in adults, the leading risk factors for children with primary hypertension are excess adiposity and suboptimal lifestyles; however, environmental stress, low birth weight, and genetic factors may also be important. Hypertensive children are highly likely to become hypertensive adults and to have measurable target organ injury, particularly left ventricular hypertrophy and vascular stiffening. Ambulatory and home blood pressure monitoring may facilitate diagnosis. Primordial prevention of hypertension through public health implementation of healthier diet and increased physical activity will reduce the prevalence of primary hypertension, and evidence-based treatment guidelines should be implemented when hypertension is diagnosed. Further research to optimize recognition and diagnosis and clinical trials to better define outcomes of treatment are needed.
RI Tran, Andrew/G-1795-2018; Falkner, Bonita/Y-8451-2019; Baker-Smith,
   Carissa/ABL-0815-2022
OI Baker-Smith, Carissa/0000-0002-7528-1586
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NR 53
TC 61
Z9 66
U1 9
U2 20
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0194-911X
EI 1524-4563
J9 HYPERTENSION
JI Hypertension
PD JUN
PY 2023
VL 80
IS 6
BP E101
EP E111
DI 10.1161/HYP.0000000000000228
PG 11
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA H9IX3
UT WOS:000999023600002
PM 36994715
OA Bronze
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Prince, SA
   Rasmussen, CL
   Biswas, A
   Holtermann, A
   Aulakh, T
   Merucci, K
   Coenen, P
AF Prince, Stephanie A.
   Rasmussen, Charlotte Lund
   Biswas, Aviroop
   Holtermann, Andreas
   Aulakh, Tarnbir
   Merucci, Katherine
   Coenen, Pieter
TI The effect of leisure time physical activity and sedentary behaviour on
   the health of workers with different occupational physical activity
   demands: a systematic review
SO INTERNATIONAL JOURNAL OF BEHAVIORAL NUTRITION AND PHYSICAL ACTIVITY
LA English
DT Review
DE Physical activity; Sedentary behaviour; Occupation; Leisure;
   Cardiovascular disease; Mortality
ID ALL-CAUSE MORTALITY; CORONARY-HEART-DISEASE; ACUTE
   MYOCARDIAL-INFARCTION; LOW-BACK-PAIN; CARDIOVASCULAR-DISEASE;
   CARDIORESPIRATORY FITNESS; EXERCISE PROGRAM; FINNISH MEN; NECK PAIN;
   FOLLOW-UP
AB Background: Although it is generally accepted that physical activity reduces the risk for chronic non-communicable disease and mortality, accumulating evidence suggests that occupational physical activity (OPA) may not confer the same health benefits as leisure time physical activity (LTPA). It is also unclear if workers in high OPA jobs benefit from LTPA the same way as those in sedentary jobs. Our objective was to determine whether LTPA and leisure time sedentary behaviour (LTSB) confer the same health effects across occupations with different levels of OPA.
   Methods: Searches were run in Medline, Embase, PsycINFO, ProQuest Public Health and Scopus from inception to June 9, 2020. Prospective or experimental studies which examined the effects of LTPA or LTSB on all-cause and cardiovascular mortality and cardiovascular disease, musculoskeletal pain, diabetes, metabolic syndrome, arrhythmias and depression among adult workers grouped by OPA (low OPA/sitters, standers, moderate OPA/intermittent movers, high OPA/heavy labourers) were eligible. Results were synthesized using narrative syntheses and harvest plots, and certainty of evidence assessed with GRADE.
   Results: The review includes 38 papers. Across all outcomes, except cardiovascular mortality, metabolic syndrome and atrial fibrillation, greater LTPA was consistently protective among low OPA, but conferred less protection among moderate and high OPA. For cardiovascular mortality and metabolic syndrome, higher levels of LTPA were generally associated with similar risk reductions among all OPA groups. Few studies examined effects in standers and none examined effects of LTSB across OPA groups.
   Conclusions: Evidence suggests that LTPA is beneficial for all workers, but with larger risk reductions among those with low compared to high OPA jobs. This suggests that, in our attempts to improve the health of workers through LTPA, tailored interventions for different occupational groups may be required. More high-quality studies are needed to establish recommended levels of LTPA/LTSB for different OPA groups.
C1 [Prince, Stephanie A.] Publ Hlth Agcy Canada, Ctr Surveillance & Appl Res, 785 Carling Ave, Ottawa, ON K1A 0K9, Canada.
   [Prince, Stephanie A.] Univ Ottawa, Fac Med, Sch Epidemiol & Publ Hlth, Ottawa, ON, Canada.
   [Rasmussen, Charlotte Lund; Holtermann, Andreas] Natl Res Ctr Working Environm, Copenhagen, Denmark.
   [Biswas, Aviroop] Inst Work & Hlth, Toronto, ON, Canada.
   [Biswas, Aviroop] Univ Toronto, Dalla Lana Sch Publ Hlth, Toronto, ON, Canada.
   [Aulakh, Tarnbir] Queens Univ, Sch Kinesiol & Hlth Studies, Kingston, ON, Canada.
   [Merucci, Katherine] Hlth Canada, Hlth Lib, Ottawa, ON, Canada.
   [Coenen, Pieter] Vrije Univ Amsterdam, Amsterdam Publ Hlth Res Inst, Dept Publ & Occupat Hlth, Amsterdam UMC, Amsterdam, Netherlands.
C3 Public Health Agency of Canada; University of Ottawa; National Research
   Centre for the Working Environment; Institute for Work & Health;
   University of Toronto; Queens University - Canada; Health Canada; Vrije
   Universiteit Amsterdam; University of Amsterdam
RP Prince, SA (corresponding author), Publ Hlth Agcy Canada, Ctr Surveillance & Appl Res, 785 Carling Ave, Ottawa, ON K1A 0K9, Canada.; Prince, SA (corresponding author), Univ Ottawa, Fac Med, Sch Epidemiol & Publ Hlth, Ottawa, ON, Canada.
EM stephanie.princeware@canada.ca
RI Coenen, Pieter/H-8195-2019; Prince, Stephanie/J-9361-2019; Lund
   Rasmussen, Charlotte/HKW-5734-2023
OI Merucci, Katherine/0000-0003-1981-7013; Coenen,
   Pieter/0000-0002-4034-7063; Biswas, Aviroop/0000-0002-0393-6280;
   Holtermann, Andreas/0000-0003-4825-5697; Lund Rasmussen,
   Charlotte/0000-0003-2193-5019; Prince, Stephanie/0000-0001-6729-5649
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NR 97
TC 81
Z9 87
U1 11
U2 37
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1479-5868
J9 INT J BEHAV NUTR PHY
JI Int. J. Behav. Nutr. Phys. Act.
PD JUL 20
PY 2021
VL 18
IS 1
AR 100
DI 10.1186/s12966-021-01166-z
PG 17
WC Nutrition & Dietetics; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nutrition & Dietetics; Physiology
GA TL5KB
UT WOS:000674895300001
PM 34284795
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Prossin, AR
   Zalcman, SS
   Evans, SJ
   McInnis, MG
   Ellingrod, VL
AF Prossin, Alan R.
   Zalcman, Steven S.
   Evans, Simon J.
   McInnis, McInnis G.
   Ellingrod, Vicki L.
TI A Pilot Study Investigating Tumor Necrosis Factor-α as a Potential
   Intervening Variable of Atypical Antipsychotic-Associated Metabolic
   Syndrome in Bipolar Disorder
SO THERAPEUTIC DRUG MONITORING
LA English
DT Article
DE cytokines; psychoneuroimmunology; bipolar disorder; metabolic syndrome;
   mediation; atypical antipsychotic; tumor necrosis factor
ID TNF-ALPHA; PREVALENCE; ADULTS; GENES; TRIAL; RISK
AB Background: Strong associations exist between tumor necrosis factor-alpha (TNF-alpha) and metabolic syndrome (MetS). Although TNF-a is associated with bipolar depression (BD), its role in atypical antipsychotic (AAP)-associated MetS in BD is unclear. Here, we investigate the potential intervening role of TNF-alpha in the indirect relationship between AAP treatment and MetS in BD.
   Materials and Methods: Using a cross-sectional design, 99 euthymic BD volunteers were stratified by the presence or the absence of MetS (National Cholesterol Education Program Adult Treatment Panel III). Serum TNF-alpha concentration, determined via chemiluminescent immunometric assays, was compared between groups (ie, MetS or no MetS). We investigated the intervening effect of TNF-alpha on the relation between AAP treatment and MetS in BD using regression techniques.
   Results: Treatment with those antipsychotics believed associated with a higher risk for MetS (ie, AAPs: olanzapine, quetiapine, risperidone, paliperidone, clozapine) was found to be associated with significantly greater TNF-alpha (F-1,F-88 = 11.2, P = 0.001, mean difference of 1.7 +/- 0.51) and a higher likelihood of MetS (F-1,F-88 = 4.5, P = 0.036) than in those not receiving treatment with an AAP. Additionally, TNF-alpha was greater (trending toward significance; T-52 = 2.0, P = 0.05) in BD volunteers with MetS and was found to have a statistically significant effect on the indirect relationship between AAP treatment and elevated waist circumference in these BD volunteers.
   Discussion: These results identify TNF-alpha as a potential intervening variable of AAP-associated MetS in BD, not previously identified in this population. Future prospective studies could assess the predictive potential of TNF-alpha in determining risk of AAP-associated MetS in BD. Given previous evidence relating TNF-alpha and mood state in BD, this study increases the importance in understanding the role of TNF-alpha in "mind-body" interactions and renews discussions of the utility of research into the clinical efficacy of TNF-alpha antagonist treatment in mood disorders.
C1 [Prossin, Alan R.; Evans, Simon J.; McInnis, McInnis G.; Ellingrod, Vicki L.] Univ Michigan, Sch Med, Dept Psychiat, Ann Arbor, MN USA.
   [Zalcman, Steven S.] Univ Med & Dent New Jersey, New Jersey Med Sch, Dept Psychiat, Newark, NJ 07103 USA.
   [Ellingrod, Vicki L.] Univ Michigan, Coll Pharm, Ann Arbor, MN USA.
C3 Rutgers University System; Rutgers University New Brunswick; Rutgers
   University Biomedical & Health Sciences
RP Prossin, AR (corresponding author), Univ Michigan, Sch Med, Dept Psychiat, 4250 Plymouth Rd,2409, Ann Arbor, MI 48109 USA.
EM prossin@med.umich.edu
RI Ellingrod, Vicki/G-8764-2012; McInnis, Melvin/F-6963-2012; Prossin,
   Alan/K-2967-2015
OI Evans, Simon/0000-0001-8112-9487; Prossin, Alan/0000-0003-1262-522X
FU National Institute of Diabetes and Digestive and Kidney Diseases
   [DK020572]; National Institute of Diabetes and Digestive and Kidney
   Diseases [P30DK020572] Funding Source: NIH RePORTER
FX This work used the Chemistry Core of the Michigan Diabetes Research and
   Training Center funded by DK020572 from the National Institute of
   Diabetes and Digestive and Kidney Diseases.
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NR 40
TC 7
Z9 7
U1 0
U2 11
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0163-4356
EI 1536-3694
J9 THER DRUG MONIT
JI Ther. Drug Monit.
PD APR
PY 2013
VL 35
IS 2
BP 194
EP 202
DI 10.1097/FTD.0b013e31827e18d2
PG 9
WC Medical Laboratory Technology; Pharmacology & Pharmacy; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Medical Laboratory Technology; Pharmacology & Pharmacy; Toxicology
GA 107DE
UT WOS:000316194100007
PM 23503445
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Bakke, J
   Haj, FG
AF Bakke, Jesse
   Haj, Fawaz G.
TI Protein-tyrosine phosphatase 1B substrates and metabolic regulation
SO SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
LA English
DT Review
DE PTP1B; Substrate; Obesity; Diabetes; ER stress; Pyruvate kinase
ID ENDOPLASMIC-RETICULUM STRESS; PYRUVATE-KINASE M2; INSULIN-RECEPTOR;
   BODY-WEIGHT; GLUCOSE-HOMEOSTASIS; SIGNAL-TRANSDUCTION; NEGATIVE
   REGULATION; MASS-SPECTROMETRY; REDOX REGULATION; S-NITROSYLATION
AB Metabolic homeostasis requires integration of complex signaling networks which, when deregulated, contribute to metabolic syndrome and related disorders. Protein-tyrosine phosphatase 1B (PTP1B) has emerged as a key regulator of signaling networks that are implicated in metabolic diseases such as obesity and type 2 diabetes. In this review, we examine mechanisms that regulate PTP1B-substrate interaction, enzymatic activity and experimental approaches to identify PTP1B substrates. We then highlight findings that implicate PTP1B in metabolic regulation. In particular, insulin and leptin signaling are discussed as well as recently identified PTP1B substrates that are involved in endoplasmic reticulum stress response, cell-cell communication, energy balance and vesicle trafficking. In summary, PTP1B exhibits exquisite substrate specificity and is an outstanding pharmaceutical target for obesity and type 2 diabetes. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Bakke, Jesse; Haj, Fawaz G.] Univ Calif Davis, Dept Nutr, Davis, CA 95616 USA.
   [Haj, Fawaz G.] Univ Calif Davis, Dept Internal Med, Div Endocrinol Diabet & Metab, Sacramento, CA 95817 USA.
   [Haj, Fawaz G.] Univ Calif Davis, Ctr Comprehens Canc, Sacramento, CA 95817 USA.
C3 University of California System; University of California Davis;
   University of California System; University of California Davis;
   University of California System; University of California Davis
RP Haj, FG (corresponding author), Univ Calif Davis, Dept Nutr, 3135 Meyer Hall, Davis, CA 95616 USA.
EM fghaj@ucdavis.edu
OI Bakke, Jesse/0000-0003-0305-5165
FU Juvenile Diabetes Research Foundation; American Diabetes Association;
   National Institutes of Health [R56 DK084317, R01 DK090492, R01 DK095359,
   K99 DK100736]
FX Thanks to Dr. Ahmed Bettaieb for comments on the manuscript and
   preparing the figure. Research in the Haj laboratory is supported by
   grants from Juvenile Diabetes Research Foundation, American Diabetes
   Association and National Institutes of Health (R56 DK084317, R01
   DK090492 and R01 DK095359 to F.G.H. and K99 DK100736 to A.B.).
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NR 132
TC 123
Z9 134
U1 1
U2 37
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 1084-9521
J9 SEMIN CELL DEV BIOL
JI Semin. Cell Dev. Biol.
PD JAN
PY 2015
VL 37
BP 58
EP 65
DI 10.1016/j.semcdb.2014.09.020
PG 8
WC Cell Biology; Developmental Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Developmental Biology
GA CC2ES
UT WOS:000350158600009
PM 25263014
OA Green Accepted, Green Published
DA 2025-06-11
ER

PT J
AU Schuler, BR
   Gardenhire, RA
   Jones, SD
   Spilsbury, JC
   Moore, SM
   Borawski, EA
AF Schuler, Brittany R.
   Gardenhire, Rachel A.
   Jones, Sarah D.
   Spilsbury, James C.
   Moore, Shirley M.
   Borawski, Elaine A.
TI Exploring the Association Between Trauma, Instability, and Youth
   Cardiometabolic Health Outcomes Over Three Years
SO JOURNAL OF ADOLESCENT HEALTH
LA English
DT Article
DE Adverse childhood experiences; Trauma; Instability; Low-income;
   Adolescence; Cardiometabolic risk; Obesity; Diabetes
ID ADVERSE CHILDHOOD EXPERIENCES; RISK; ADOLESCENTS; BEHAVIORS; CHILDREN;
   OBESITY; STRESS; SCALE
AB Purpose: Childhood adversity plays a fundamental role in predicting youth cardiometabolic health. Our understanding of how adverse experiences in childhood should best be conceptualized remains elusive, based on one-dimensional measures of adversity. The present study fills a major gap in existing research by examining two distinct forms of threat and instability -related exposures that may impact cardiometabolic risk (CMR) in adolescence. Methods: We explore two specific subtypes of adversity: trauma (e.g., badly hurt, victim of crime, loss of close person) and instability (e.g., moving, change of schools, change in household structure) as differential influences that can accumulate to impact early childhood onset of CMR (body mass index, high -density lipoprotein (HDL), low -density lipoprotein, diastolic and systolic blood pressure, triglycerides, C -reactive protein, insulin sensitivity). Secondary data were drawn from a randomized control behavioral trial of youth recruited during sixth grade from urban Cleveland (Ohio) schools beginning in 2012-2014 (n 1/4 360) and followed for 3 years. Participants reported on 12 adverse experiences, six trauma- and six instability -specific. Multiple regression assessed effects of prospective and accumulative indices of trauma and instability with 3 -year trajectories of eight objective CMR markers. Results: Instability was associated with increased body mass index, decreased high -density lipoprotein, and increased C -reactive protein slopes. Trauma was associated with trends in triglyceride levels but not with any other CMR outcomes. Discussion: Experiences with instability distinctly impacted adolescent CMR. Future research is needed to examine factors that can enhance stability for families in marginalized communities. (c) 2023 Society for Adolescent Health and Medicine. Published by Elsevier Inc. This is an open access article under the CC BY -NC -ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
C1 [Schuler, Brittany R.] Temple Univ, Coll Publ Hlth, Sch Social Work, Philadelphia, PA USA.
   [Gardenhire, Rachel A.] Case Western Reserve Univ, Sch Med, Cleveland, OH USA.
   [Jones, Sarah D.] Dominican Univ, Borra Coll Hlth Sci Nutr, River Forest, IL USA.
   [Spilsbury, James C.] Case Western Reserve Univ, Sch Med, Dept Populat & Quantitat Hlth Sci, Cleveland, OH USA.
   [Moore, Shirley M.] Case Western Reserve Univ, Frances Payne Bolton Sch Nursing, Cleveland, OH USA.
   [Borawski, Elaine A.] Case Western Reserve Univ, Dept Nutr, Cleveland, OH USA.
   [Schuler, Brittany R.] Temple Univ, Sch Social Work, 1301 Cecil B Moore Ave Ritter Annex 549, Philadelphia, PA 19122 USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE); Temple
   University; University System of Ohio; Case Western Reserve University;
   University System of Ohio; Case Western Reserve University; University
   System of Ohio; Case Western Reserve University; University System of
   Ohio; Case Western Reserve University; Pennsylvania Commonwealth System
   of Higher Education (PCSHE); Temple University
RP Schuler, BR (corresponding author), Temple Univ, Sch Social Work, 1301 Cecil B Moore Ave Ritter Annex 549, Philadelphia, PA 19122 USA.
EM brittany.schuler@temple.edu
RI Spilsbury, James/O-6880-2019; Moore, Shirley/AAB-8911-2019; Borawski,
   Elaine/R-9959-2019
OI Schuler, Brittany/0000-0002-2869-6260
FU National Institute on Minority Health and Health Disparities of the
   National Institutes of Health [K01MD015326]; National Heart, Lung, and
   Blood Institute of the National Institutes of Health [U01 HL103622];
   Prevention Research Centers Program of the Centers for Disease Control
   and Prevention [U48DP005030]
FX This study was supported by the National Institute on Minority Health
   and Health Disparities of the National Institutes of Health to Brittany
   R. Schuler (Grant Number K01MD015326) . This is a secondary study of
   research supported by the National Heart, Lung, and Blood Institute of
   the National Institutes of Health (Grant Number U01 HL103622) and the
   Prevention Research Centers Program of the Centers for Disease Control
   and Prevention (Grant Number U48DP005030) ; Clinicaltrials.gov
   #NCT01514279) .
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NR 55
TC 1
Z9 1
U1 0
U2 6
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1054-139X
EI 1879-1972
J9 J ADOLESCENT HEALTH
JI J. Adolesc. Health
PD FEB
PY 2024
VL 74
IS 2
BP 301
EP 311
DI 10.1016/j.jadohealth.2023.08.049
EA JAN 2024
PG 11
WC Psychology, Developmental; Public, Environmental & Occupational Health;
   Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Public, Environmental & Occupational Health; Pediatrics
GA HY2U1
UT WOS:001163013600001
PM 37843478
OA hybrid, Green Accepted
DA 2025-06-11
ER

PT J
AU Quesada, I
   de Paola, M
   Torres-Palazzolo, C
   Camargo, A
   Ferder, L
   Manucha, W
   Castro, C
AF Quesada, Isabel
   de Paola, Matilde
   Torres-Palazzolo, Carolina
   Camargo, Alejandra
   Ferder, Leon
   Manucha, Walter
   Castro, Claudia
TI Effect of Garlic's Active Constituents in Inflammation, Obesity and
   Cardiovascular Disease
SO CURRENT HYPERTENSION REPORTS
LA English
DT Review
DE Garlic; Organosulfur compounds; Atherosclerosis; Overweight;
   Mitochondria dysfunction; Oxidative stress
ID ALLIUM-SATIVUM L.; OXIDATIVE STRESS; MITOCHONDRIAL DYSFUNCTION;
   DIALLYL-DISULFIDE; ENDOTHELIAL FUNCTION; METABOLIC SYNDROME;
   ORGANOSULFUR COMPOUNDS; BIOACTIVE COMPOUNDS; INSULIN-RESISTANCE;
   SULFUR-COMPOUNDS
AB Purpose of Review Several studies have attributed garlic's beneficial properties to its high content of organosulfur compounds (OSCs). Here, we summarized recent studies published and some own findings regarding OSCs and its effects on cardiovascular disease, inflammation, and obesity. Recent Finding The analysis of the multiple actions produced by OSCs suggests that many of its bioactivities interfere against inflammation, oxidative stress, obesogenic effects, and mitochondrial dysfunction. Accumulating evidence from in vitro, animal, and human studies reinforce the notion that OSCs modify signaling pathways that trigger chronic diseases, and to highlight, actions over these pathways are related to the treatment of disorders addressed in this review. Garlic's bioactive OSCs behave like a nutraceutical panacea because they cover a broad spectrum of applications with promising impact for the prevention and treatment of prevalent chronic pathologies associated with low-grade inflammation.
C1 [Quesada, Isabel; de Paola, Matilde; Manucha, Walter; Castro, Claudia] Consejo Nacl Invest Cient & Tecn, Inst Med & Expt Biol Cuyo IMBECU, Mendoza, Argentina.
   [Quesada, Isabel; de Paola, Matilde; Manucha, Walter; Castro, Claudia] Univ Nacl Cuyo, Fac Ciencias Med Mendoza, Mendoza, Argentina.
   [Torres-Palazzolo, Carolina; Camargo, Alejandra] Consejo Nacl Invest Cient & Tecn, Agr Biol Inst Mendoza IBAM, Mendoza, Argentina.
   [Torres-Palazzolo, Carolina; Camargo, Alejandra] Univ Nacl Cuyo, Fac Ciencias Agr Mendoza, Mendoza, Argentina.
   [Ferder, Leon] Univ Miami, Miller Sch Med, Dept Pediat, Div Nephrol, Miami, FL 33136 USA.
C3 Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET);
   Instituto de Medicina y BiologIa Experimental de Cuyo (IMBECU);
   University Nacional Cuyo Mendoza; Consejo Nacional de Investigaciones
   Cientificas y Tecnicas (CONICET); University Nacional Cuyo Mendoza;
   University of Miami
RP Castro, C (corresponding author), Consejo Nacl Invest Cient & Tecn, Inst Med & Expt Biol Cuyo IMBECU, Mendoza, Argentina.; Castro, C (corresponding author), Univ Nacl Cuyo, Fac Ciencias Med Mendoza, Mendoza, Argentina.
EM ccastro@fcm.uncu.edu.ar
OI Torres Palazzolo, Carolina/0000-0003-1412-9836; Castro,
   Claudia/0000-0002-8428-2484; Camargo, Alejandra
   Beatriz/0000-0001-9749-8842; Manucha, Walter/0000-0002-2279-7626
FU Secretary of Science, Technology and Posgrade [06/J469, 06/J514];
   Universidad Nacional de Cuyo, Mendoza Argentina; PIP-CONICET
   [PICT-2013-2379, PICT-2016-4541]
FX Authors received the following grants: from the Secretary of Science,
   Technology and Posgrade No. 06/J469 (to CC) and No. 06/J514 (to WM),
   Universidad Nacional de Cuyo, Mendoza Argentina; PIP-CONICET 2015-17 (to
   CC); PICT-2013-2379 (to AC) and PICT-2016-4541 (to WM).
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NR 96
TC 45
Z9 46
U1 0
U2 14
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1522-6417
EI 1534-3111
J9 CURR HYPERTENS REP
JI Curr. Hypertens. Rep.
PD JAN 10
PY 2020
VL 22
IS 1
AR 6
DI 10.1007/s11906-019-1009-9
PG 10
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA KO2QS
UT WOS:000515394900002
PM 31925548
DA 2025-06-11
ER

PT J
AU Mazzola, D
   Fornari, F
   Vigano, G
   Oro, T
   Costa, JAV
   Bertolin, TE
AF Mazzola, Daiane
   Fornari, Fernando
   Vigano, Gabriela
   Oro, Tatiana
   Vieira Costa, Jorge Alberto
   Bertolin, Telma Elita
TI Spirulina platensis Enhances the Beneficial Effect of Exercise on
   Oxidative Stress and the Lipid Profile in Rats
SO BRAZILIAN ARCHIVES OF BIOLOGY AND TECHNOLOGY
LA English
DT Article
DE Exercise; antioxidant; cholesterol; lipid peroxidation
ID ANTIOXIDANT; SUPPLEMENTATION; DAMAGE; ATHEROSCLEROSIS; PEROXIDATION;
   DYSFUNCTION; METABOLISM; MECHANISMS; ENDURANCE; TOXICITY
AB This study aimed to evaluate the effect of Spirulina platensis and moderate exercise on oxidative stress and lipid profiles in the rats. Forty male Wistar rats were allocated to the following 10-week treatments, three times a week: exercise (E, 30 min swimming), S. platensis (SP, 26 mg/Kg); exercise and Spirulina (ES); and control (C). Outcomes were Thiobarbituric Acid Reactive Substances (TBARS) in serum and brain, and cholesterol and triglycerides (TG) in serum. Rats treated with exercise showed lower brain TBARS than the controls, mostly in association with S. platensis. In the groups E and ES, serum TBARS decreased after intervention. Compared with the controls, both E and ES prevented an increase in cholesterol and reduced triglycerides. Results demonstrated that S. platensis enhanced the beneficial effect of exercise on oxidative stress and lipid profiles in rats, which might be a promising approach for treating metabolic syndrome in humans.
C1 [Mazzola, Daiane; Vigano, Gabriela; Oro, Tatiana; Bertolin, Telma Elita] Univ Passo Fundo, Inst Ciencias Biol, Lab Tecnol Fermentacoes, Passo Fundo, RS, Brazil.
   [Fornari, Fernando] Univ Passo Fundo, Fac Med, Passo Fundo, RS, Brazil.
   [Vieira Costa, Jorge Alberto] Univ Fed Rio Grande, Fac Quim & Engn Alimentos, Rio Grande, RS, Brazil.
C3 Universidade de Passo Fundo; Universidade de Passo Fundo; Universidade
   Federal do Rio Grande
RP Bertolin, TE (corresponding author), Univ Passo Fundo, Inst Ciencias Biol, Lab Tecnol Fermentacoes, Passo Fundo, RS, Brazil.
EM telma@upf.br
RI Fornari, Fernando/GOJ-7615-2022; Bertolin, Telma/AAG-8473-2021; Costa,
   Jorge Alberto Vieira/L-3999-2013; ORO, TATIANA/H-2801-2014
OI Fornari, Fernando/0000-0003-0899-329X; Costa, Jorge Alberto
   Vieira/0000-0001-8042-7642; ORO, TATIANA/0000-0002-8415-1863
FU CNPq; PPGEH
FX The authors would like to thank the Instituto de Ciencias Biologicas -
   UPF - which provided the location and facilities to perform the
   experimental work. This work was supported by grants from CNPq and
   PPGEH.
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NR 44
TC 7
Z9 9
U1 1
U2 11
PU INST TECNOLOGIA PARANA
PI CURITIBA-PARANA
PA RUA PROF ALGACYR MUNHOZ MADER 3775-CIC, 81350-010 CURITIBA-PARANA,
   BRAZIL
SN 1516-8913
EI 1678-4324
J9 BRAZ ARCH BIOL TECHN
JI Braz. Arch. Biol. Technol.
PD NOV-DEC
PY 2015
VL 58
IS 6
BP 961
EP 969
DI 10.1590/S1516-89132015060216
PG 9
WC Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics
GA CY2ZT
UT WOS:000366277400019
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Huang, SH
   Chen, SC
   Geng, JH
   Wu, DW
   Li, CH
AF Huang, Szu-Han
   Chen, Szu-Chia
   Geng, Jiun-Hung
   Wu, Da-Wei
   Li, Chien-Hsun
TI Metabolic Syndrome and High-Obesity-Related Indices Are Associated with
   Poor Cognitive Function in a Large Taiwanese Population Study Older than
   60 Years
SO NUTRIENTS
LA English
DT Article
DE metabolic syndrome; obesity-related indices; Mini-Mental State
   Examination; cognitive impairment
ID LOW BLOOD-PRESSURE; MINI-MENTAL-STATE; CARDIOVASCULAR-DISEASE;
   INSULIN-RESISTANCE; BRAIN ATROPHY; RISK; DEMENTIA; IMPAIRMENT;
   DEPRESSION; TRIGLYCERIDES
AB Metabolic syndrome (MetS) is prevalent in Taiwan; however, the association between MetS and cognitive function is unclear. The aim of this study was to explore the associations between MetS, its components, and obesity-related indices with cognitive function in a large Taiwanese cohort. We enrolled a total of 28,486 participants who completed the Mini-Mental State Examination (MMSE) questionnaire, which was used to evaluate cognitive function. MetS was defined according to the NCEP-ATP III guidelines and modified criteria for Asians. Ten obesity-related indices were also evaluated: body mass index (BMI), abdominal volume index (AVI), body adiposity index (BAI), waist-hip ratio (WHR), a body shape index (ABSI), lipid accumulation product, waist-to-height ratio (WHtR), conicity index (CI), body roundness index (BRI), and triglyceride glucose index. The prevalence of MetS and its components (except for hypertriglyceridemia) and the number of MetS components increased while the cognitive impairment worsened (from MMSE >= 24, 18-23 to 0-17). In addition, increases in all obesity-related index values were associated with a decline in cognitive function (from MMSE >= 24, 18-23 to 0-17, ANOVA p < 0.001). Multivariable analysis showed that MetS (p = 0.002), abdominal obesity (p < 0.001), low high-density lipoprotein cholesterol (p = 0.004), and hyperglycemia (p = 0.012) were significantly associated with a low MMSE score. Further, participants with high BMI (p = 0.001), WHR (p < 0.001), WHtR (p < 0.001), BRI (p < 0.001), CI (p < 0.001), BAI (p < 0.001), AVI (p < 0.001), and ABSI (p < 0.001) values were significantly associated with a low MMSE score. Our results show that MetS and its components (except for hypertriglyceridemia and high blood pressure) may lead to cognitive impairment, and that high values of obesity-related indices were associated with poor cognitive function.
C1 [Huang, Szu-Han] Kaohsiung Med Univ, Dept Post Baccalaureate Med, Kaohsiung 807, Taiwan.
   [Chen, Szu-Chia; Wu, Da-Wei] Kaohsiung Med Univ, Kaohsiung Municipal Siaogang Hosp, Dept Internal Med, Kaohsiung 812, Taiwan.
   [Chen, Szu-Chia] Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Internal Med, Div Nephrol, Kaohsiung 807, Taiwan.
   [Chen, Szu-Chia] Kaohsiung Med Univ, Coll Med, Fac Med, Kaohsiung 807, Taiwan.
   [Chen, Szu-Chia] Kaohsiung Med Univ, Res Ctr Environm Med, Kaohsiung 807, Taiwan.
   [Geng, Jiun-Hung] Kaohsiung Med Univ, Kaohsiung Municipal Siaogang Hosp, Dept Urol, Kaohsiung 812, Taiwan.
   [Geng, Jiun-Hung] Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Urol, Kaohsiung 807, Taiwan.
   [Wu, Da-Wei] Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Internal Med, Div Pulm & Crit Care Med, Kaohsiung 807, Taiwan.
   [Li, Chien-Hsun] Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Neurol, Kaohsiung 807, Taiwan.
   [Li, Chien-Hsun] Kaohsiung Med Univ, Kaohsiung Municipal Siaogang Hosp, Dept Neurol, Kaohsiung 812, Taiwan.
   [Li, Chien-Hsun] Kaohsiung Med Univ, Kaohsiung Municipal Siaogang Hosp, Integrated Ctr Hlth & Long Term Care, Kaohsiung 812, Taiwan.
C3 Kaohsiung Medical University; Kaohsiung Medical University; Kaohsiung
   Municipal Siao-Gang Hospital; Kaohsiung Medical University; Kaohsiung
   Medical University Hospital; Kaohsiung Medical University; Kaohsiung
   Medical University; Kaohsiung Medical University; Kaohsiung Municipal
   Siao-Gang Hospital; Kaohsiung Medical University; Kaohsiung Medical
   University Hospital; Kaohsiung Medical University; Kaohsiung Medical
   University Hospital; Kaohsiung Medical University; Kaohsiung Medical
   University Hospital; Kaohsiung Medical University; Kaohsiung Municipal
   Siao-Gang Hospital; Kaohsiung Medical University; Kaohsiung Municipal
   Siao-Gang Hospital
RP Li, CH (corresponding author), Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Neurol, Kaohsiung 807, Taiwan.; Li, CH (corresponding author), Kaohsiung Med Univ, Kaohsiung Municipal Siaogang Hosp, Dept Neurol, Kaohsiung 812, Taiwan.; Li, CH (corresponding author), Kaohsiung Med Univ, Kaohsiung Municipal Siaogang Hosp, Integrated Ctr Hlth & Long Term Care, Kaohsiung 812, Taiwan.
EM gavin40708123@gmail.com; scarchenone@yahoo.com.tw; u9001090@gmail.com;
   u8900030@yahoo.com.tw; gavli@kmu.edu.tw
RI 蘇, 河名/AAE-9843-2019; GENG, JIUNHUNG/AAB-2322-2022; Wu,
   Da-Wei/AHB-2174-2022
OI Wu, Da-Wei/0000-0001-5737-6613; Chen, Szu-Chia/0000-0002-1610-4184;
   HUANG, SZU-HAN/0000-0002-2425-1002
FU Research Center for Environmental Medicine, Kaohsiung Medical
   University, Kaohsiung, Taiwan, from The Featured Areas Research Center
   Program within Ministry of Education (MOE) in Taiwan; Kaohsiung Medical
   University Research Center Grants [KMU-TC111A01, KMUTC111IFSP01]
FX This work was supported partially by the Research Center for
   Environmental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan,
   from The Featured Areas Research Center Program within the framework of
   the Higher Education Sprout Project by the Ministry of Education (MOE)
   in Taiwan and by Kaohsiung Medical University Research Center Grants
   (KMU-TC111A01 and KMUTC111IFSP01).
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NR 65
TC 19
Z9 20
U1 2
U2 22
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD APR
PY 2022
VL 14
IS 8
AR 1535
DI 10.3390/nu14081535
PG 15
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nutrition & Dietetics
GA 0S2SB
UT WOS:000786128200001
PM 35458097
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Song, J
   Huang, YP
   Zheng, WJ
   Yan, J
   Cheng, M
   Zhao, RX
   Chen, L
   Hu, C
   Jia, WP
AF Song, Jun
   Huang, Yeping
   Zheng, Wenjian
   Yan, Jing
   Cheng, Min
   Zhao, Ruxing
   Chen, Li
   Hu, Cheng
   Jia, Weiping
TI Resveratrol reduces intracellular reactive oxygen species levels by
   inducing autophagy through the AMPK-mTOR pathway
SO FRONTIERS OF MEDICINE
LA English
DT Article
DE resveratrol; reactive oxygen species; AMPK; mTOR; autophagy
ID OXIDATIVE STRESS; ENDOTHELIAL DYSFUNCTION; CELLS; MECHANISMS;
   PHOSPHORYLATION
AB Oxidative stress induced by free fatty acid aggravates endothelial injury, which leads to diabetic cardiovascular complications. Reduction of intracellular oxidative stress may attenuate these pathogenic processes. The dietary polyphenol resveratrol reportedly exerts potential protective effects against endothelial injury. This study determined whether resveratrol can reduce the palmitic acid (PA)-induced generation of reactive oxygen species (ROS) and further explored the underlying molecular mechanisms. We found that resveratrol significantly reduced the PA-induced endothelial ROS levels in human aortic endothelial cells. Resveratrol also induced endothelial cell autophagy, which mediated the effect of resveratrol on ROS reduction. Resveratrol stimulated autophagy via the AMP-activated protein kinase (AMPK)-mTOR pathway. Taken together, these data suggest that resveratrol prevents PA-induced intracellular ROS by autophagy regulation via the AMPK-mTOR pathway. Thus, the induction of autophagy by resveratrol may provide a novel therapeutic candidate for cardioprotection in metabolic syndrome.
C1 [Song, Jun; Huang, Yeping; Yan, Jing; Hu, Cheng; Jia, Weiping] Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Shanghai Key Clin Ctr Metab Dis, Shanghai Diabet Inst,Shanghai Key Lab Diabet Mell, Shanghai 200233, Peoples R China.
   [Song, Jun; Zhao, Ruxing; Chen, Li] Shandong Univ, Dept Endocrinol, Qilu Hosp, Jinan 250012, Shandong, Peoples R China.
   [Song, Jun] Tongji Univ, Sch Med, Shanghai East Hosp, Dept Endocrinol, Shanghai 200120, Peoples R China.
   [Zheng, Wenjian] Qingdao Haici Med Treatment Grp, Dept Geriatr, Qingdao 266000, Peoples R China.
   [Cheng, Min] Huangdao Dis Prevent & Control Ctr, Qingdao 266555, Peoples R China.
C3 Shanghai Jiao Tong University; Shandong University; Tongji University
RP Hu, C; Jia, WP (corresponding author), Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Shanghai Key Clin Ctr Metab Dis, Shanghai Diabet Inst,Shanghai Key Lab Diabet Mell, Shanghai 200233, Peoples R China.
EM alfredhc@sjtu.edu.cn; wpjia@sjtu.edu.cn
RI Jia, Weiping/B-7483-2012; Hu, Cheng/C-3346-2008
OI Jia, Weiping/0000-0002-6244-2168; Hu, Cheng/0000-0003-4314-2386
FU outstanding young scientist research grant in Shandong Province
   [2013BSE27128]; National Natural Science Foundation of China [81370943];
   China Postdoctoral Science Foundation [2015M580334]; Shanghai Municipal
   Health and Family Planning Commission Project [20134189]
FX The present work was funded by outstanding young scientist research
   grant in Shandong Province (No. 2013BSE27128), National Natural Science
   Foundation of China (No. 81370943), China Postdoctoral Science
   Foundation (No. 2015M580334) and Shanghai Municipal Health and Family
   Planning Commission Project (No. 20134189).
CR Antonioli M, 2017, TRENDS BIOCHEM SCI, V42, P28, DOI 10.1016/j.tibs.2016.09.008
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NR 32
TC 50
Z9 56
U1 3
U2 45
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 2095-0217
EI 2095-0225
J9 FRONT MED-PRC
JI Front. Med.
PD DEC
PY 2018
VL 12
IS 6
BP 697
EP 706
DI 10.1007/s11684-018-0655-7
PG 10
WC Oncology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Research & Experimental Medicine
GA HE4PL
UT WOS:000453348800010
PM 30421395
DA 2025-06-11
ER

PT J
AU Xiong, Y
   Zhang, FX
   Wu, CJ
   Zhang, YC
   Huang, XYZ
   Qin, F
   Yuan, JH
AF Xiong, Yang
   Zhang, Fuxun
   Wu, Changjing
   Zhang, Yangchang
   Huang, Xiaoyingzi
   Qin, Feng
   Yuan, Jiuhong
TI The Circadian Syndrome Predicts Lower Urinary Tract Symptoms Suggestive
   of Benign Prostatic Hyperplasia Better Than Metabolic Syndrome in Aging
   Males: A 4-Year Follow-Up Study
SO FRONTIERS IN MEDICINE
LA English
DT Article
DE aging males; benign prostatic hyperplasia; circadian syndrome; lower
   urinary tract symptoms; metabolic syndrome
ID TESTOSTERONE
AB Background: The prevalence of lower urinary tract symptoms (LUTS) suggestive of benign prostate hyperplasia (BPH) increases in men. Although several risk factors, including metabolic syndrome (MetS) and depression, were identified, the underlying etiological factor remains unclear. Recently, circadian syndrome (CircS) was proposed as a novel risk cluster based on MetS. To compare the predictive power of the CircS and MetS for LUTS/BPH, this study was performed.
   Materials and Methods: In the baseline survey, 4,390 men older than 40 years from the China Health and Retirement Longitudinal Study were enrolled. Of them, 3,658 men were followed in the 2015 survey. Logistic regression was adopted to examine the relationships between CircS, MetS, and LUTS/BPH. To further verify the association, propensity score matching was used for sensitivity analyses. Moreover, the participants who had LUTS/BPH at the baseline were excluded to test the longitudinal relationships between CircS, MetS, and LUTS/BPH. In addition, we employed the receiver operating characteristic (ROC) curve analysis to compare the predictive power using the number of components of CircS and MetS. The DeLong test was used to test the disparities of area under the curves (AUCs).
   Results: The prevalence of CircS and MetS in aging men was 30.23 and 38.36%, respectively. The odds ratios for prevalent LUTS/BPH were 1.61 (95% CI = 1.29-2.00, P < 0.001) and 1.34 (95% CI = 1.08-1.66, P < 0.01), respectively, in aging men. This increased risk was also observed in incident LUTS/BPH. The prevalence of LUTS/BPH in normal, CircS alone, MetS alone, and both CircS and MetS groups was 6.96, 8.77, 7.83, and 10.77%, respectively. The AUCs for CircS predicting prevalent and incident LUTS/BPH were higher than those for MetS (0.582 vs. 0.556 for incident LUTS/BPH, P < 0.001; 0.574 vs. 0.561 for prevalent LUTS/BPH, P < 0.05).
   Conclusions: The CircS predicts both incident and prevalent LUTS/BPH better than MetS.
C1 [Xiong, Yang; Zhang, Fuxun; Wu, Changjing; Huang, Xiaoyingzi; Qin, Feng; Yuan, Jiuhong] Sichuan Univ, West China Hosp, Androl Lab, Chengdu, Peoples R China.
   [Xiong, Yang; Zhang, Fuxun; Yuan, Jiuhong] Sichuan Univ, West China Hosp, Dept Urol, Chengdu, Peoples R China.
   [Zhang, Yangchang] Chongqing Med Univ, Sch Publ Hlth & Management, Dept Epidemiol & Hlth Stat, Chongqing, Peoples R China.
C3 Sichuan University; Sichuan University; Chongqing Medical University
RP Yuan, JH (corresponding author), Sichuan Univ, West China Hosp, Androl Lab, Chengdu, Peoples R China.; Yuan, JH (corresponding author), Sichuan Univ, West China Hosp, Dept Urol, Chengdu, Peoples R China.
EM jiuhongyuan2107@163.com
RI Qin, Feng/JWP-5386-2024; Yang, Xiong/AGP-5601-2022
OI Yuan, Jiuhong/0000-0002-0991-1463; Xiong, Yang/0000-0003-3901-2394; Qin,
   Feng/0000-0001-9521-7146
FU Natural Science Foundation of China [81871147, 82071639]; Chengdu
   Science and Technology Program [2019-YFYF-00087-SN]
FX Funding This work was supported by the Natural Science Foundation of
   China (81871147 and 82071639) and the Chengdu Science and Technology
   Program (2019-YFYF-00087-SN).
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NR 27
TC 23
Z9 23
U1 0
U2 4
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 2296-858X
J9 FRONT MED-LAUSANNE
JI Front. Med.
PD SEP 21
PY 2021
VL 8
AR 715830
DI 10.3389/fmed.2021.715830
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA WB3TB
UT WOS:000703497000001
PM 34621761
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Agarwal, AK
AF Agarwal, AK
TI Cortisol metabolism and visceral obesity:: Role of 11β-hydroxysteroid
   dehydrogenase type I enzyme and reduced co-factor NADPH
SO ENDOCRINE RESEARCH
LA English
DT Article
DE 11 beta-HSD; co-factor NADPH; visceral obesity; cortisone reductase
   deficiency; G6PDH; H6PDH
ID ADIPOSE-TISSUE; EXPRESSION; GENE; RECEPTOR; CLONING; STRESS; G6PD; CDNA;
   MICE
AB Several factors including genetic and environmental play a role in the development of obesity and the metabolic syndrome. The transgenic mouse overexpressing 11beta-hydroxysteroid dehydrogenase (11beta-HSD) develops visceral obesity. However, it remains unclear how a ubiquitously expressed 11beta-HSD1 enzyme affects adipose tissue so much that it would lead to obesity. In this commentary we explore the possibility that increased intracellular availability of reduced co-factor, NADPH, could exacerbate the enzymatic activity.
C1 Univ Texas, SW Med Ctr, Div Nutr & Metab Dis, Dept Internal Med, Dallas, TX 75390 USA.
   Univ Texas, SW Med Ctr, Ctr Human Nutr, Dallas, TX 75390 USA.
C3 University of Texas System; University of Texas Dallas; University of
   Texas Southwestern Medical Center Dallas; University of Texas System;
   University of Texas Dallas; University of Texas Southwestern Medical
   Center Dallas
RP Agarwal, AK (corresponding author), Univ Texas, SW Med Ctr, Div Nutr & Metab Dis, Dept Internal Med, 5323 Harry Hines Blvd, Dallas, TX 75390 USA.
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NR 25
TC 15
Z9 27
U1 0
U2 3
PU MARCEL DEKKER INC
PI NEW YORK
PA 270 MADISON AVE, NEW YORK, NY 10016 USA
SN 0743-5800
J9 ENDOCR RES
JI Endocr. Res.
PY 2003
VL 29
IS 4
BP 411
EP 418
DI 10.1081/ERC-120026947
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 752LX
UT WOS:000187163300005
PM 14682470
DA 2025-06-11
ER

PT J
AU Hayeems, RZ
   Miller, FA
   Barg, CJ
   Bombard, Y
   Carroll, JC
   Tam, K
   Kerr, E
   Chakraborty, P
   Potter, BK
   Patton, S
   Bytautas, JP
   Taylor, L
   Davies, C
   Milburn, J
   Price, A
   Gonska, T
   Keenan, K
   Ratjen, F
   Guttmann, A
AF Hayeems, Robin Z.
   Miller, Fiona A.
   Barg, Carolyn J.
   Bombard, Yvonne
   Carroll, June C.
   Tam, Karen
   Kerr, Elizabeth
   Chakraborty, Pranesh
   Potter, Beth K.
   Patton, Sarah
   Bytautas, Jessica P.
   Taylor, Louise
   Davies, Christine
   Milburn, Jennifer
   Price, April
   Gonska, Tanja
   Keenan, Katherine
   Ratjen, Felix
   Guttmann, Astrid
TI Psychosocial Response to Uncertain Newborn Screening Results for Cystic
   Fibrosis
SO JOURNAL OF PEDIATRICS
LA English
DT Article
ID METABOLIC SYNDROME; DIAGNOSIS; CHILD; PERCEPTIONS; GUIDELINES;
   MANAGEMENT; DISORDERS; KNOWLEDGE; INFANTS; PARENTS
AB Objective To explore the psychosocial implications of diagnostic uncertainty that result from inconclusive results generated by newborn bloodspot screening (NBS) for cystic fibrosis (CF).
   Study design Using a mixed methods prospective cohort study of children who received NBS for CF, we compared psychosocial outcomes of parents whose children who received persistently inconclusive results with those whose children received true positive or screen-negative results.
   Results Mothers of infants who received inconclusive results (n = 17), diagnoses of CF (n = 15), and screen-negative results (n = 411) were surveyed; 23 parent interviews were completed. Compared with mothers of infants with true positive/screen-negative results, mothers of infants with inconclusive results reported greater perceived uncertainty (P < .006) but no differences in anxiety or vulnerability (P > .05). Qualitatively, parents valued being connected to experts but struggled with the meaning of an uncertain diagnosis, worried about their infant's health-related vulnerability, and had mixed views about surveillance.
   Conclusion Inconclusive CF NBS results were not associated with anxiety or vulnerability but led to health-related uncertainty and qualitative concerns. Findings should be considered alongside efforts to optimize protocols for CF screening and surveillance. Educational and psychosocial supports are warranted for these families.
C1 [Hayeems, Robin Z.; Guttmann, Astrid] Hosp Sick Children, Child Hlth Evaluat Sci, Res Inst, Toronto, ON, Canada.
   [Hayeems, Robin Z.; Miller, Fiona A.; Barg, Carolyn J.; Bombard, Yvonne; Patton, Sarah; Bytautas, Jessica P.; Guttmann, Astrid] Univ Toronto, Inst Hlth Policy Management & Evaluat, Toronto, ON, Canada.
   [Bombard, Yvonne] St Michaels Hosp, Li Ka Shing Knowledge Inst, Toronto, ON, Canada.
   [Carroll, June C.] Univ Toronto, Mt Sinai Hosp, Dept Family & Community Med, Sinai Hlth Syst, Toronto, ON, Canada.
   [Tam, Karen] Hosp Sick Children, Dept Pediat, Div Clin & Metab Genet, Toronto, ON, Canada.
   [Kerr, Elizabeth] Hosp Sick Children, Dept Psychol, Toronto, ON, Canada.
   [Kerr, Elizabeth; Ratjen, Felix; Guttmann, Astrid] Univ Toronto, Dept Pediat, Fac Med, Toronto, ON, Canada.
   [Chakraborty, Pranesh; Davies, Christine; Milburn, Jennifer] Childrens Hosp Eastern Ontario, Newborn Screening Ontario, Ottawa, ON, Canada.
   [Chakraborty, Pranesh] Univ Ottawa, Fac Med, Dept Pediat, Ottawa, ON, Canada.
   [Potter, Beth K.] Univ Ottawa, Fac Med, Sch Epidemiol Publ Hlth & Prevent Med, Ottawa, ON, Canada.
   [Bytautas, Jessica P.] Univ Helsinki, Dept Publ Hlth, Helsinki, Finland.
   [Taylor, Louise; Keenan, Katherine; Guttmann, Astrid] Hosp Sick Children, Dept Pediat, Toronto, ON, Canada.
   [Price, April] Childrens Hosp Western Ontario, Dept Pediat Respirol, London, ON, Canada.
   [Gonska, Tanja] Hosp Sick Children, Div Gastroenterol, Dept Pediat, Toronto, ON, Canada.
   [Gonska, Tanja] Hosp Sick Children, Res Inst, Physiol & Expt Med, Toronto, ON, Canada.
   [Ratjen, Felix] Hosp Sick Children, Dept Pediat, Div Resp Med, Toronto, ON, Canada.
   [Guttmann, Astrid] Inst Clin Evaluat Sci, Hlth Syst Planning & Evaluat Res Program, Toronto, ON, Canada.
C3 University of Toronto; Hospital for Sick Children (SickKids); University
   of Toronto; University of Toronto; Saint Michaels Hospital Toronto; Li
   Ka Shing Knowledge Institute; University of Toronto; Sinai Health System
   Toronto; University of Toronto; Hospital for Sick Children (SickKids);
   University of Toronto; Hospital for Sick Children (SickKids); University
   of Toronto; University of Ottawa; Children's Hospital of Eastern
   Ontario; University of Ottawa; University of Ottawa; University of
   Helsinki; University of Toronto; Hospital for Sick Children (SickKids);
   Western University (University of Western Ontario); University Western
   Ontario Hospital; University of Toronto; Hospital for Sick Children
   (SickKids); University of Toronto; Hospital for Sick Children
   (SickKids); University of Toronto; Hospital for Sick Children
   (SickKids); University of Toronto; Institute for Clinical Evaluative
   Sciences (ICES)
RP Hayeems, RZ (corresponding author), Hosp Sick Children, Res Inst, 686 Bay St,11-9710, Toronto, ON M5G 0A4, Canada.
EM robin.hayeems@sickkids.ca
RI Carroll, June/K-2096-2017; Bytautas, Jessica/F-3066-2016
OI Bytautas, Jessica/0000-0002-7931-2036; Miller,
   Fiona/0000-0003-4953-6255; Ratjen, Felix/0000-0003-4057-6592; Hayeems,
   Robin/0000-0003-3269-8004; Price, April/0000-0001-7994-8715
FU Canadian Institutes of Health Research operating grant [106505]
FX Supported by a Canadian Institutes of Health Research operating grant
   (106505). The authors declare no conflicts of interest.
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NR 35
TC 31
Z9 32
U1 0
U2 4
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0022-3476
EI 1097-6833
J9 J PEDIATR-US
JI J. Pediatr.
PD MAY
PY 2017
VL 184
BP 165
EP +
DI 10.1016/j.jpeds.2017.01.049
PG 8
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Pediatrics
GA EU5WH
UT WOS:000401104300033
PM 28279431
DA 2025-06-11
ER

PT J
AU Cosín-Sales, J
   Pizzi, C
   Brown, S
   Kaski, JC
AF Cosín-Sales, J
   Pizzi, C
   Brown, S
   Kaski, JC
TI C-reactive protein, clinical presentation, and ischemic activity in
   patients with chest pain and normal coronary angiograms
SO JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
LA English
DT Article
ID CARDIAC SYNDROME-X; ENDOTHELIAL DYSFUNCTION; MYOCARDIAL-ISCHEMIA;
   ANGINA; ARTERIES; RESISTANCE; DISEASE
AB OBJECTIVES We sought to investigate the relationship among C-reactive protein (hs-CRP), clinical characteristics, exercise stress test responses, and ST-segment changes during daily life in patients with typical chest pain and normal coronary angiograms (CPNCA).
   BACKGROUND Patients with CPNCA have coronary microvascular endothelial dysfunction and myocardial ischemia. Elevated hs-CRP levels have been related to atherogenesis and endothelial dysfunction. The relationship between hs-CRP and disease activity has not been previously investigated in CPNCA patients.
   METHODS We studied 137 consecutive CPNCA patients (mean age, 57 +/- 9; 33 men). All completed standardized angina questionnaires, underwent exercise stress testing, 24-h ambulatory electrocardiogram (ECG) monitoring (Holter), and hs-CRP measurements at study entry.
   RESULTS C-reactive protein levels (mg/l) were higher in patients with frequent (2.9 +/- 3.3) and prolonged (3.9 +/- 4.1) chest pain episodes, and in those with ST-segment depression on exercise testing (2.6 +/- 2.8) and Holter monitoring (3.4 +/- 3.1) compared with patients with occasional (1.3 +/- 1.2; p = 0.002) or shorter chest pain (1.5 +/- 1.3; p < 0.001) episodes, negative exercise stress testing (1.1 +/- 1.1; p < 0.001), and no ST-segment shifts on Holter monitoring (0.9 +/- 0.7; p < 0.001). Moreover, we found a correlation between hs-CRP concentration and number of ischemic episodes during Holter monitoring (r = 0.65; p < 0.001) and with the magnitude of ST-segment depression on exercise testing (r = -0.43; p < 0.001). The hs-CRP was the only independent variable (multivariate logistic regression) capable of predicting positive findings on Holter monitoring (odds ratio [OR], 3.8; confidence interval [CI], 2.3 to 6.2) and exercise testing (OR, 1.7; Cl, 1.2 to 2.2).
   CONCLUSIONS The hs-CRP correlates with symptoms and ECG markers of myocardial ischemia in CPNCA patients. Whether hs-CRP is related to the pathogenesis of angina in these patients deserves further investigation. (C) 2003 by the American College of Cardiology Foundation.
C1 St George Hosp, Sch Med, Dept Cardiol Sci, Coronary Artery Dis Res Unit, London SW17 0RE, England.
C3 City St Georges, University of London
RP St George Hosp, Sch Med, Dept Cardiol Sci, Coronary Artery Dis Res Unit, Cranmer Terrance, London SW17 0RE, England.
EM jkaski@sghms.ac.uk
RI Kaski, Juan Carlos/LKM-8031-2024; PIZZI, Carmine/C-8394-2012
OI Pizzi, Carmine/0000-0002-4048-675X; Cosin-Sales,
   Juan/0000-0002-4249-557X
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NR 23
TC 125
Z9 130
U1 0
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0735-1097
EI 1558-3597
J9 J AM COLL CARDIOL
JI J. Am. Coll. Cardiol.
PD MAY 7
PY 2003
VL 41
IS 9
BP 1468
EP 1474
DI 10.1016/S0735-1097(03)00243-2
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 674HR
UT WOS:000182631800007
PM 12742283
OA Bronze
DA 2025-06-11
ER

PT J
AU Furuto, Y
   Kawamura, M
   Yamashita, J
   Yoshikawa, T
   Namikawa, A
   Isshiki, R
   Takahashi, H
   Shibuya, Y
AF Furuto, Yoshitaka
   Kawamura, Mariko
   Yamashita, Jumpei
   Yoshikawa, Takahiro
   Namikawa, Akio
   Isshiki, Rei
   Takahashi, Hiroko
   Shibuya, Yuko
TI Relationship Between Helicobacter pylori Infection and
   Arteriosclerosis
SO INTERNATIONAL JOURNAL OF GENERAL MEDICINE
LA English
DT Review
DE Helicobacter pylori infection; arteriosclerosis; hypertension
ID ISCHEMIC-HEART-DISEASE; BLOOD-PRESSURE; ATHEROSCLEROTIC DISEASES;
   CORONARY ATHEROSCLEROSIS; ENDOTHELIAL DYSFUNCTION; INSULIN-RESISTANCE;
   METABOLIC SYNDROME; VIRULENT-STRAINS; OXIDATIVE STRESS; ASSOCIATION
AB It is reported that Helicobacter pylori (H. pylori) infection may be linked to non-digestive tract diseases, such as arteriosclerosis including dyslipidemia, diabetes, obesity, hypertension, and cardiovascular disease. Therefore, we reviewed recent studies available in PubMed dealing with the mechanisms of arteriosclerosis due to H. pylori infection and the effects of H. pylori eradication. Conventional studies suggested that H. pylori infection may increase the risk of arteriosclerosis. A large interventional study is required to clarify the causal relationships and the effects of bacterial eradication.
C1 [Furuto, Yoshitaka; Kawamura, Mariko; Yamashita, Jumpei; Yoshikawa, Takahiro; Namikawa, Akio; Isshiki, Rei; Takahashi, Hiroko; Shibuya, Yuko] NTT Med Ctr, Dept Hypertens & Nephrol, Shinagawa Ku, 5-9-22 Higasi Gotanda, Tokyo 1418625, Japan.
C3 Kanto Medical Center NTT EC
RP Furuto, Y (corresponding author), NTT Med Ctr, Dept Hypertens & Nephrol, Shinagawa Ku, 5-9-22 Higasi Gotanda, Tokyo 1418625, Japan.
EM furuto19761006@yahoo.co.jp
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NR 87
TC 12
Z9 12
U1 1
U2 30
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
EI 1178-7074
J9 INT J GEN MED
JI Int. J. Gen. Med.
PY 2021
VL 14
BP 1533
EP 1540
DI 10.2147/IJGM.S303071
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA RS7GE
UT WOS:000643942400001
PM 33935515
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Lee, M
   Kowdley, KV
AF Lee, Maximilian
   Kowdley, Kris V.
TI Alcohol's Effect on Other Chronic Liver Diseases
SO CLINICS IN LIVER DISEASE
LA English
DT Article
DE Alcohol; Autoimmune hepatitis; Fatty liver disease; Hepatitis B;
   Hepatitis C; Hemochromatosis; Fibrosis; Cirrhosis
ID HEPATITIS-C VIRUS; HIGH-FAT DIET; HEPATOCELLULAR-CARCINOMA; HEREDITARY
   HEMOCHROMATOSIS; FIBROSIS PROGRESSION; METABOLIC SYNDROME; CORE PROTEIN;
   B-VIRUS; CIGARETTE-SMOKING; OXIDATIVE STRESS
AB In addition to directly causing liver disease, alcohol consumption is a common comorbid condition with other chronic liver diseases and may exacerbate liver injury, particularly in nonalcoholic fatty liver disease, chronic viral hepatitis, hereditary hemochromatosis, and autoimmune liver diseases. This synergism can result in increased hepatic inflammation and accelerated rates of fibrosis, with more rapid and earlier development of cirrhosis, and also increase the risk for liver cancer and death from liver disease.
C1 [Lee, Maximilian; Kowdley, Kris V.] Virginia Mason Med Ctr, Liver Ctr Excellence, Seattle, WA 98101 USA.
C3 Virginia Mason Medical Center
RP Kowdley, KV (corresponding author), Virginia Mason Med Ctr, Liver Ctr Excellence, 1100 9th Ave,Mailstop C3-GAS, Seattle, WA 98101 USA.
EM kris.kowdley@vmmc.org
RI Kowdley, Kris/AAF-5202-2019
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NR 67
TC 17
Z9 19
U1 0
U2 9
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 1089-3261
EI 1557-8224
J9 CLIN LIVER DIS
JI Clin. Liver Dis.
PD NOV
PY 2012
VL 16
IS 4
BP 827
EP +
DI 10.1016/j.cld.2012.08.010
PG 12
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 058FL
UT WOS:000312619400011
PM 23101984
DA 2025-06-11
ER

PT J
AU Perez-Rubio, KG
   Villar, MMD
   Cortez-Navarrete, M
AF Perez-Rubio, Karina G.
   Mendez-del Villar, Miriam
   Cortez-Navarrete, Marisol
TI The Role of Garlic in Metabolic Diseases: A Review
SO JOURNAL OF MEDICINAL FOOD
LA English
DT Review
DE dyslipidemia; garlic; hypertension; metabolic syndrome; obesity; type 2
   diabetes mellitus
ID TYPE-2 DIABETES-MELLITUS; BLOOD-PRESSURE; NITRIC-OXIDE; POWDER TABLETS;
   ORGANOSULFUR COMPOUNDS; DIETARY-SUPPLEMENTS; CARDIOVASCULAR RISK;
   SERUM-CHOLESTEROL; HYDROGEN-SULFIDE; OXIDATIVE STRESS
AB Garlic (Allium sativum L.) is a popular spice that has been widely used for thousands of years in traditional medicine. Several organosulfur compounds in garlic have been linked to its beneficial effects on health. Evidence from preclinical studies and clinical trials supports garlic's antihypertensive, antidiabetic, antiobesity, and hypolipidemic effects. This study aims to summarize clinical trial evidence regarding the effects of garlic on metabolic diseases and its mechanisms of action.
C1 [Perez-Rubio, Karina G.; Cortez-Navarrete, Marisol] Univ Guadalajara, Hlth Sci Univ Ctr, Inst Expt & Clin Therapeut, Dept Physiol, Guadalajara, Jalisco, Mexico.
   [Mendez-del Villar, Miriam] Univ Guadalajara, Univ Ctr Tonala, Multidisciplinary Hlth Res Ctr, Biomed Sci Dept, Tonala, Jalisco, Mexico.
   [Cortez-Navarrete, Marisol] Univ Guadalajara, Hlth Sci Univ Ctr, Inst Expt & Clin Therapeut, Dept Physiol, Sierra Mojada 950,Colonia Independencia, Guadalajara 44340, Mexico.
C3 Universidad de Guadalajara; Universidad de Guadalajara; Universidad de
   Guadalajara
RP Cortez-Navarrete, M (corresponding author), Univ Guadalajara, Hlth Sci Univ Ctr, Inst Expt & Clin Therapeut, Dept Physiol, Sierra Mojada 950,Colonia Independencia, Guadalajara 44340, Mexico.
EM marisol.cortez@academicos.udg.mx
RI Villar, Miriam/ABF-1251-2021
OI MENDEZ-DEL VILLAR, MIRIAM/0000-0002-9249-7709
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NR 75
TC 8
Z9 8
U1 1
U2 20
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1096-620X
EI 1557-7600
J9 J MED FOOD
JI J. Med. Food
PD JUL 1
PY 2022
VL 25
IS 7
BP 683
EP 694
DI 10.1089/jmf.2021.0146
EA JUN 2022
PG 12
WC Chemistry, Medicinal; Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Food Science & Technology; Nutrition &
   Dietetics
GA 3A9FR
UT WOS:000807876800001
PM 35675656
DA 2025-06-11
ER

PT J
AU Sen, N
   Tavil, Y
   Erdamar, H
   Yazici, HU
   Çakir, E
   Bilgi, C
   Erbil, MK
   Poyraz, F
   Okyay, K
   Turfan, M
   Cemri, M
   Akgul, EO
AF Sen, Nihat
   Tavil, Yusuf
   Erdamar, Huesamettin
   Yazici, Hueseyin Ugur
   Cakir, Erdinc
   Bilgi, Cumhur
   Erbil, Mehmet Kemal
   Poyraz, Fatih
   Okyay, Kaan
   Turfan, Murat
   Cemri, Mustafa
   Akgul, Emin Ozgur
TI Nebivolol therapy improves endothelial function and increases exercise
   tolerance in patients with cardiac syndrome X
SO ANADOLU KARDIYOLOJI DERGISI-THE ANATOLIAN JOURNAL OF CARDIOLOGY
LA English
DT Article
DE Cardiac syndrome X; nebivolol; endothelial function; asymmetric
   dimethylarginine; nitric oxide
ID NORMAL CORONARY-ARTERIES; TYPE-2 DIABETES-MELLITUS; OXIDE SYNTHASE
   INHIBITOR; ORAL L-ARGININE; ASYMMETRIC DIMETHYLARGININE;
   ESSENTIAL-HYPERTENSION; DOUBLE-BLIND; MICROVASCULAR FUNCTION; FOREARM
   VASCULATURE; ANGINA-PECTORIS
AB Objective: We sought to determine whether nebivolol affects coronary endothelial function and exercise induced ischemia in patients with cardiac syndrome X (CSX).
   Methods: The study protocol undertaken was based on a single-blind randomized controlled prospective study. After a 2-week washout period, 38 patients with cardiac syndrome X were randomized to receive either nebivolol 5 mg daily (n=19) or metoprolol 50 mg daily (n=19) in a single-blind design for 12 weeks. The control group under study was consisted of 16 age- and gender-matched subjects with negative treadmill exercise tests. Plasma endothelial nitric oxide INN), L-arginine, and asymmetric dimethylarginine (ADMA) were measured in all patients at baseline and after 12 weeks of treatment. Statistical differences among groups were tested by one-way analysis of variance and unpaired samples t test for parametric; Kruskal-Wallis and Mann-Whitney U tests for non-parametric variables, respectively. A paired - samples t test was used to compare continuous variables before and after drug therapy.
   Results: At baseline, plasma level of NOx, L-arginine, and L-arginine/ADMA ratio were lower (p<0.001 for all) in patients with CSX than in the control patients. Whereas, the plasma ADMA levels were increased in the patient group (p<0.001). After 12 weeks of drug therapy, the patients taking nebivolol had increased levels of plasma NOx, plasma L-arginine, the L-arginine/ADMA ratio and decreased levels of plasma ADMA compared to those of the patients taking metoprolol (p<0.001). In addition, exercise duration to 1-mm ST depression and total exercise duration significantly increased after treatment in the nebivolol group compared to the metoprolol group (p<0.01). In the nebivolol group, Canadian Cardiovascular Society INS) angina classification improved by one or more categories in 12 (70%) patients, whereas it deteriorated or remained in the same category in 5 (30%) patients. Meanwhile, in the metoprolol group, the CCS angina classification improved by one or more categories in 7 (41%), whereas it deteriorated or remained in the same category in 10 (59%) patients.
   Conclusion: Circulating endothelial function parameters (plasma ADMA, L-arginine, NOx levels) were impaired in patients with CSX. Nebivolol treatment was associated with better improvements in both circulating endothelial function and exercise stress test parameters than metoprolol. We believe that further studies are needed to evaluate the effects of nebivolol treatment on long-term clinical outcomes in patients with CSX. (Anadolu Kardiyol Derg 2009;9:371-9)
C1 [Sen, Nihat; Tavil, Yusuf; Yazici, Hueseyin Ugur; Poyraz, Fatih; Okyay, Kaan; Turfan, Murat; Cemri, Mustafa] Gazi Univ, Fac Med, Dept Cardiol, Ankara, Turkey.
   [Erdamar, Huesamettin] Beytepe Mil Hosp, Dept Biochem, Ankara, Turkey.
   [Cakir, Erdinc; Bilgi, Cumhur] Gulhane Mil Med Acad, Dept Emergency Med, Ankara, Turkey.
   [Erbil, Mehmet Kemal; Akgul, Emin Ozgur] Gulhane Mil Med Acad, Dept Biochem, Ankara, Turkey.
C3 Gazi University; Beytepe Military Hospital; Gulhane Military Medical
   Academy; Gulhane Military Medical Academy
RP Sen, N (corresponding author), Gazi Univ, Fac Med, Dept Cardiol, Ankara, Turkey.
EM nihatdrsen@yahoo.com
RI Durakoglugil, Emre/Q-3547-2019; Turfan, Murat/B-8972-2014; Poyraz,
   Fatih/JZD-3254-2024; okyay, kaan/AAK-7355-2020
OI okyay, kaan/0000-0001-6134-8826
CR Abbasi F, 2001, AM J CARDIOL, V88, P1201, DOI 10.1016/S0002-9149(01)02063-X
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NR 34
TC 32
Z9 32
U1 0
U2 10
PU AVES YAYINCILIK
PI FINDIKZADE
PA IBRAHIM KARA, KIZILELMA CAD 5-3, FINDIKZADE, ISTANBUL 34096, TURKEY
SN 1302-8723
J9 ANADOLU KARDIYOL DER
JI Anadolu Kardiyol. Derg.
PD OCT
PY 2009
VL 9
IS 5
BP 371
EP 379
PG 9
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 512QU
UT WOS:000271265900003
PM 19819787
DA 2025-06-11
ER

PT J
AU Li, KL
   Li, T
   Yang, T
   Lin, YZ
   Liao, YT
   Gan, ZY
AF Li, Kanglai
   Li, Tong
   Yang, Ting
   Lin, Youzhen
   Liao, Yingtao
   Gan, Zhaoyu
TI Prevalence of insulin resistance and its associated factors in
   drug-naïve patients with bipolar disorder among Han Chinese population
SO BMC PSYCHIATRY
LA English
DT Article
DE Bipolar disorder; Insulin resistance; Metabolic syndrome; Waist
   circumference; Clinical characteristics
ID METABOLIC SYNDROME; DIABETES-MELLITUS; MOOD DISORDERS; RATING-SCALE;
   FEATURES; DEPRESSION; SYMPTOMS; DISEASE; ILLNESS; OBESITY
AB Background Metabolic syndrome (Mets) is commonly seen in bipolar disorder (BD). As the key component and early biological index of Mets, insulin resistance (IR) among BD has received more and more attention. However, little is known about the prevalence of IR and its associated factors in drug-na & iuml;ve patients with (BD), especially among Han Chinese population. Methods A cross-sectional study was conducted on 125 drug-na & iuml;ve patients with bipolar disorder (BD) and 85 healthy controls (HC). The Homeostatic Model Assessment of insulin resistance (HOMA-IR) was calculated, and IR was defined as HOMA-IR greater than the 75th percentile value for health controls (2.35). Clinical characteristics of BD were collected through semi-structural interview performed by a trained interviewer with background of psychiatric education. Results Among the measured anthropocentric variables including BMI, waist circumference, abdomen circumference, hipline, and hip-waist ratio, waist circumference was found to be the most closely related to IR (0R = 1.070, 95%CI = 1.031-1.110, P < 0.001). Male was another factor that was associated with IR (OR = 2.281, 95%CI = 1.107-4.702, P = 0.025). After adjusted for gender and waist circumference, the risk of IR was significantly higher in bipolar disorder than in healthy controls (OR = 2.66, 95%CI = 1.364-5.214, P = 0.004). No significant association was found between IR and any of the observed physical and mental comorbidities, any characteristic of illness course including age onset, number of mixed episodes, types of current state, duration of current episode, duration of illness course, rapid cycling, number of mood episodes, and subgroup of BD. Hypersomnia was the only symptomatic feature that was significantly associated with IR (OR = 0.316, 95%CI = 0.124-0.803, P = 0.016). Conclusions Bipolar disorder increases two-to-three-fold risk of IR, both circumference and male are the risk factors of IR but hypersomnia act as a protective factor.
C1 [Li, Kanglai; Li, Tong; Yang, Ting; Lin, Youzhen; Liao, Yingtao; Gan, Zhaoyu] Sun Yat Sen Univ, Affiliated Hosp 3, 600 Tianhe Rd, Guangzhou, Guangdong, Peoples R China.
C3 Sun Yat Sen University
RP Gan, ZY (corresponding author), Sun Yat Sen Univ, Affiliated Hosp 3, 600 Tianhe Rd, Guangzhou, Guangdong, Peoples R China.
EM ganzhy@mail.sysu.edu.cn
FU Third Affiliated Hospital of Sun Yat-Sen University, Clinical Research
   Program and the Natural Science Foundation of Guangdong Province, China
FX Not applicable.
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NR 45
TC 0
Z9 0
U1 1
U2 3
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-244X
J9 BMC PSYCHIATRY
JI BMC Psychiatry
PD MAY 23
PY 2024
VL 24
IS 1
AR 388
DI 10.1186/s12888-024-05838-5
PG 9
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychiatry
GA RU9S1
UT WOS:001230297500004
PM 38783222
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Wang, Y
   Fu, W
   Liu, J
AF Wang, Yan
   Fu, Wei
   Liu, Jing
TI Neurodevelopment in children with intrauterine growth restriction:
   adverse effects and interventions
SO JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
LA English
DT Review
DE Adverse effects; interventions; intrauterine growth restriction;
   neurodevelopment
ID INDIVIDUALIZED DEVELOPMENTAL CARE; INDUCED CEREBRAL APOPTOSIS;
   FOR-GESTATIONAL-AGE; PRETERM INFANTS; FETAL RATS; COGNITIVE FUNCTION;
   ASSESSMENT PROGRAM; OXIDATIVE STRESS; YOUNG-ADULTS; RISK-FACTORS
AB Intrauterine growth restriction (IUGR) is associated with higher rates of fetal, perinatal, and neonatal morbidity and mortality. The consequences of IUGR include short-term metabolic, hematological and thermal disturbances that lead to metabolic syndrome in children and adults. Additionally, IUGR severely affects short- and long-term fetal brain development and brain function (including motor, cognitive and executive function) and neurobehavior, especially neuropsychology. This review details the adverse effects of IUGR on fetal brain development and discusses intervention strategies.
C1 [Wang, Yan; Fu, Wei; Liu, Jing] Beijing Mil Gen Hosp, Dept Neonatol & NICU, Bayi Childrens Hosp, Beijing 100700, Peoples R China.
   [Wang, Yan] Taian City Cent Hosp Shandong Prov, Dept Neonatol & NICU, Tai An, Shandong, Peoples R China.
RP Liu, J (corresponding author), Beijing Mil Gen Hosp, Dept Neonatol & NICU, Bayi Childrens Hosp, 5 Nanmen Cang, Beijing 100700, Peoples R China.
EM liujingbj@live.cn
RI Liu, Jing/AFQ-7746-2022
FU National Natural Science Foundation of China [81170577, 81471087]
FX The authors declare that they have no competing interests. This work was
   supported by the National Natural Science Foundation of China (81170577
   & 81471087).
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NR 82
TC 38
Z9 47
U1 1
U2 29
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1476-7058
EI 1476-4954
J9 J MATERN-FETAL NEO M
JI J. Matern.-Fetal Neonatal Med.
PD FEB 16
PY 2016
VL 29
IS 4
BP 660
EP 668
DI 10.3109/14767058.2015.1015417
PG 9
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA CY9RI
UT WOS:000366743600028
PM 25758617
DA 2025-06-11
ER

PT J
AU Van Gaal, LF
   Mertens, IL
   De Block, CE
AF Van Gaal, Luc F.
   Mertens, Ilse L.
   De Block, Christophe E.
TI Mechanisms linking obesity with cardiovascular disease
SO NATURE
LA English
DT Article
ID CORONARY-HEART-DISEASE; FREE FATTY-ACIDS; C-REACTIVE PROTEIN;
   INSULIN-RESISTANCE; ADIPOSE-TISSUE; METABOLIC SYNDROME;
   PHYSICAL-ACTIVITY; RISK-FACTORS; MYOCARDIAL-INFARCTION; OXIDATIVE STRESS
AB Obesity increases the risk of cardiovascular disease and premature death. Adipose tissue releases a large number of bioactive mediators that influence not only body weight homeostasis but also insulin resistance - the core feature of type 2 diabetes - as well as alterations in lipids, blood pressure, coagulation, fibrinolysis and inflammation, leading to endothelial dysfunction and atherosclerosis. We are now beginning to understand the underlying mechanisms as well as the ways in which smoking and dyslipidaemia increase, and physical activity attenuates, the adverse effects of obesity on cardiovascular health.
C1 Univ Antwerp, Univ Antwerp Hosp, Fac Med, Dept Diabetol Metab & Clin Nutr, B-2650 Antwerp, Belgium.
C3 University of Antwerp
RP Van Gaal, LF (corresponding author), Univ Antwerp, Univ Antwerp Hosp, Fac Med, Dept Diabetol Metab & Clin Nutr, Wilrijkstr 10, B-2650 Antwerp, Belgium.
EM luc.van.gaal@uza.be
RI De+Block, Christophe/ABE-1600-2020
OI De Block, Christophe/0000-0002-0679-3203
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NR 81
TC 2152
Z9 2394
U1 7
U2 237
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0028-0836
EI 1476-4687
J9 NATURE
JI Nature
PD DEC 14
PY 2006
VL 444
IS 7121
BP 875
EP 880
DI 10.1038/nature05487
PG 6
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 116LW
UT WOS:000242805400045
PM 17167476
DA 2025-06-11
ER

PT J
AU Hayasaka, T
   Fuda, H
   Hui, SP
   Chiba, H
AF Hayasaka, Takahiro
   Fuda, Hirotoshi
   Hui, Shu-Ping
   Chiba, Hitoshi
TI Imaging Mass Spectrometry Reveals a Decrease of Cardiolipin in the
   Kidney of NASH Model Mice
SO ANALYTICAL SCIENCES
LA English
DT Article
DE Imaging; matrix-assisted laser desorption/ionization; non-alcoholic
   steatohepatitis; kidney; cardiolipin
ID NONALCOHOLIC FATTY LIVER; METABOLIC SYNDROME; OXIDATIVE STRESS; DISEASE;
   PREVALENCE; NAFLD
AB Non-alcoholic steatohepatitis (NASH) can be complicated with chronic kidney disease (CKD). In this study, changes in the distribution of biomolecules in the kidney were studied in NASH model mice with the use of imaging mass spectrometry (IMS). The mass spectra and ion images of IMS showed that the signals of cardiolipin (CL) species were decreased in the kidney cortex of the NASH mice. The decrease of CL might therefore suggest the kidney involvement of NASH.
C1 [Hayasaka, Takahiro; Fuda, Hirotoshi; Hui, Shu-Ping; Chiba, Hitoshi] Hokkaido Univ, Fac Hlth Sci, Hlth Innovat & Technol Ctr, Lab Adv Lipid Anal,Kita Ku, Kita 12,Nishi 5, Sapporo, Hokkaido 0600812, Japan.
C3 Hokkaido University
RP Hui, SP (corresponding author), Hokkaido Univ, Fac Hlth Sci, Hlth Innovat & Technol Ctr, Lab Adv Lipid Anal,Kita Ku, Kita 12,Nishi 5, Sapporo, Hokkaido 0600812, Japan.
FU Ministry of Education, Culture, Sports, Science and Technology, Japan;
   Japan Society for the Promotion of Science
FX This research is supported by the Regional Innovation Strategy Support
   Program, Sapporo Health Innovation "Smart-H", of the Ministry of
   Education, Culture, Sports, Science and Technology, Japan, and partially
   by the Grant-in-Aid for Scientific Research from the Japan Society for
   the Promotion of Science.
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NR 17
TC 10
Z9 11
U1 0
U2 13
PU JAPAN SOC ANALYTICAL CHEMISTRY
PI TOKYO
PA 26-2 NISHIGOTANDA 1 CHOME SHINAGAWA-KU, TOKYO, 141, JAPAN
SN 0910-6340
EI 1348-2246
J9 ANAL SCI
JI Anal. Sci.
PD APR
PY 2016
VL 32
IS 4
BP 473
EP 476
DI 10.2116/analsci.32.473
PG 4
WC Chemistry, Analytical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry
GA DK8HS
UT WOS:000375168400016
PM 27063723
OA gold
DA 2025-06-11
ER

PT J
AU Naowar, M
   Dickton, D
   Francis, J
AF Naowar, Maisha
   Dickton, Darby
   Francis, Jimi
TI Cardiometabolic Risk Factors Associated with Magnesium and Vitamin D
   Nutrients during Pregnancy-A Narrative Review
SO NUTRIENTS
LA English
DT Review
DE gestational diabetes; gestational hypertension; cardiometabolic changes;
   vitamin D; magnesium
ID C-REACTIVE PROTEIN; D DEFICIENCY; INSULIN SENSITIVITY; UNITED-STATES;
   ION CHANNELS; HYPERTENSION; SUPPLEMENTATION; METABOLISM; CALCITRIOL;
   DEPRESSION
AB This narrative review comprehensively explores the cardiometabolic implications of two vital nutrients, magnesium and vitamin D, during gestation. Magnesium, a key regulator of vascular tone, glucose metabolism, and insulin sensitivity, plays a crucial role in mitigating gestational hypertension and diabetes, a point this review underscores. Conversely, vitamin D, critical for immune response and calcium level maintenance, is linked to gestational diabetes and hypertensive disorders of pregnancy. The authors aim to enhance comprehension of the complex interaction between these nutrients and cardiometabolic function in pregnancy, knowledge that is pivotal for optimizing maternal-fetal outcomes. The mother's health during pregnancy significantly influences the long-term development of the fetus. Recognizing the impact of these nutrient deficiencies on the physiology of cardiometabolic cycles underscores the importance of adequate nutritional support during pregnancy. It also emphasizes the pressing need for future research and targeted interventions to alleviate the burden of pregnancy complications, highlighting the crucial role of healthcare professionals, researchers, and policy makers in obstetrics and gynecology in this endeavor.
C1 [Naowar, Maisha] Univ Texas San Antonio, Coll Hlth Community & Policy, Dept Publ Hlth, San Antonio, TX 78249 USA.
   [Dickton, Darby] Fdn Maternal Infant & Lactat Knowledge, San Antonio, TX 78249 USA.
   [Francis, Jimi] Univ Texas San Antonio, Coll Hlth Community & Policy, Dept Kinesiol, San Antonio, TX 78249 USA.
C3 University of Texas System; University of Texas at San Antonio (UTSA);
   University of Texas System; University of Texas at San Antonio (UTSA)
RP Francis, J (corresponding author), Univ Texas San Antonio, Coll Hlth Community & Policy, Dept Kinesiol, San Antonio, TX 78249 USA.
EM maisha.naowar@my.utsa.edu; ddickton@foundation4milk.org;
   jimi.francis@utsa.edu
FX This research received no external funding.
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NR 99
TC 1
Z9 1
U1 1
U2 3
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD AUG
PY 2024
VL 16
IS 16
AR 2630
DI 10.3390/nu16162630
PG 14
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA E7H7G
UT WOS:001304684900001
PM 39203767
OA gold
DA 2025-06-11
ER

PT J
AU Takeshita, J
   Grewal, S
   Langan, SM
   Mehta, NN
   Ogdie, A
   Van Voorhers, AS
   Gelfand, JM
AF Takeshita, Junko
   Grewal, Sungat
   Langan, Sinead M.
   Mehta, Nehal N.
   Ogdie, Alexis
   Van Voorhers, Abby S.
   Gelfand, Joel M.
TI Psoriasis and comorbid diseases Implications for management
SO JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
LA English
DT Review
DE cardiovascular disease; chronic kidney disease; comorbidities; Crohn's
   disease; depression; infection; lymphoma; metabolic syndrome;
   nonalcoholic fatty liver disease; psoriasis; psoriatic arthritis;
   screening; vaccination
ID POPULATION-BASED-COHORT; FACTOR-ALPHA THERAPY; CARDIOVASCULAR
   RISK-FACTORS; NECROSIS-FACTOR INHIBITORS; SQUAMOUS-CELL CARCINOMA;
   HEPATITIS-B-VIRUS; NATIONAL-PSORIASIS; RHEUMATOID-ARTHRITIS; BIOLOGIC
   THERAPY; TREATMENT RECOMMENDATIONS
AB As summarized in the first article in this continuing medical education series, the currently available epidemiologic data suggest that psoriasis may be a risk factor for cardiometabolic disease. Emerging data also suggest associations between psoriasis and other comorbidities beyond psoriatic arthritis, including chronic kidney disease, inflammatory bowel disease, hepatic disease, certain malignancies, infections, and mood disorders. Recognizing the comorbid disease burden of psoriasis is essential for ensuring comprehensive care of patients with psoriasis. The clinical implications of the comorbid diseases that are associated with psoriasis and recommendations for clinical management are reviewed in this article.
C1 [Takeshita, Junko; Grewal, Sungat; Gelfand, Joel M.] Univ Penn, Perelman Sch Med, Dept Dermatol, Philadelphia, PA 19104 USA.
   [Takeshita, Junko; Ogdie, Alexis; Gelfand, Joel M.] Univ Penn, Ctr Clin Epidemiol & Biostat, Perelman Sch Med, Dept Epidemiol & Biostat, Philadelphia, PA 19104 USA.
   [Ogdie, Alexis] Univ Penn, Perelman Sch Med, Div Rheumatol, Philadelphia, PA 19104 USA.
   [Langan, Sinead M.] London Sch Hyg & Trop Med, London, England.
   [Langan, Sinead M.] St Johns Inst Dermatol, London, England.
   [Mehta, Nehal N.] NHLBI, Bldg 10, Bethesda, MD 20892 USA.
   [Van Voorhers, Abby S.] Eastern Virginia Med Sch, Dept Dermatol, Norfolk, VA 23501 USA.
C3 University of Pennsylvania; University of Pennsylvania; University of
   Pennsylvania; University of London; London School of Hygiene & Tropical
   Medicine; University of London; King's College London; National
   Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood
   Institute (NHLBI); Eastern Virginia Medical School
RP Takeshita, J (corresponding author), Univ Penn, Perelman Ctr Adv Med, Dept Dermatol, 3400 Civ Ctr Blvd,7th Floor,South Tower,Off 728, Philadelphia, PA 19104 USA.
EM Junko.Takeshita@uphs.upenn.edu
RI Mehta, Nehal/W-4669-2019
OI Gelfand, Joel/0000-0003-3480-2661; Langan, Sinead/0000-0002-7022-7441
FU National Institute of Arthritis and Musculoskeletal and Skin Diseases
   [K24AR064310, T32AR00746532, K23AR063764, K23AR068433]; Dermatology
   Foundation Career Development Award; Intramural Research Program at the
   National Institutes of Health [ZIAHL006193-02]; National Institute for
   Health Research Clinician Scientist Fellowship [NIHR/CS/010/014]; Pfizer
   Inc; AbbVie; Celgene; Amgen; Eli Lilly; Janssen; Novartis Corp;
   Regeneron
FX Supported in part by National Institute of Arthritis and Musculoskeletal
   and Skin Diseases grants K24AR064310 (Dr Gelfand), T32AR00746532 (Ms
   Grewal), K23AR063764 (Dr Ogdie), and K23AR068433 (Dr Takeshita), a
   Dermatology Foundation Career Development Award (Dr Takeshita), the
   Intramural Research Program at the National Institutes of Health grant
   ZIAHL006193-02 (Mehta), and a National Institute for Health Research
   Clinician Scientist Fellowship (grant NIHR/CS/010/014 to Dr Langan). The
   findings and conclusions in this report are those of the authors and do
   not necessarily represent the views of the UK Department of Health.Dr
   Takeshita has received a research grant (to the Trustees of the
   University of Pennsylvania) from Pfizer Inc and payment for continuing
   medical education work related to psoriasis. Dr Mehta is a full-time
   employee of the US Government. Dr Ogdie receives research grants from
   AbbVie (to the Group for Research and Assessment of Psoriasis and
   Psoriatic Arthritis [GRAPPA]), Celgene (to GRAPPA), and Pfizer Inc (to
   the Trustees of the University of Pennsylvania and GRAPPA), and has
   served as a consultant for Novartis, receiving honoraria. Dr Van
   Voorhees has served as a consultant for AbbVie, Amgen, Aqua,
   AstraZeneca, Celgene, Corrona, Dermira, Janssen, Leo, Novartis, and
   Pfizer, receiving honoraria; received a research grant from AbbVie; and
   has other relationship with Merck. Dr Gelfand has served as a consultant
   for AbbVie, AstraZeneca, Celgene Corp, Coherus, Eli Lilly, Janssen
   Biologics (formerly Centocor), Sanofi, Merck, Novartis Corp, Endo, and
   Pfizer Inc, receiving honoraria; receives research grants (to the
   Trustees of the University of Pennsylvania) from AbbVie, Amgen, Eli
   Lilly, Janssen, Novartis Corp, Regeneron, and Pfizer Inc; and received
   payment for continuing medical education work related to psoriasis. Dr
   Gelfand is a co-patent holder of resiquimod for treatment of cutaneous
   T-cell lymphoma. No other potential conflicts of interest were declared
   by the authors.
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NR 99
TC 151
Z9 160
U1 0
U2 12
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0190-9622
J9 J AM ACAD DERMATOL
JI J. Am. Acad. Dermatol.
PD MAR
PY 2017
VL 76
IS 3
BP 393
EP 403
DI 10.1016/j.jaad.2016.07.065
PG 11
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA ES0KG
UT WOS:000399214700011
PM 28212760
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Dogaru, G
   Bulboaca, AE
   Gheban, D
   Boarescu, PM
   Rus, V
   Festila, D
   Sitar-Taut, AV
   Stanescu, I
AF Dogaru, Gabriela
   Bulboaca, Adriana Elena
   Gheban, Dan
   Boarescu, Paul Mihai
   Rus, Vasile
   Festila, Dana
   Sitar-Taut, Adela-Viviana
   Stanescu, Ioana
TI Effect of Liposomal Curcumin on Acetaminophen Hepatotoxicity by
   Down-regulation of Oxidative Stress and Matrix Metalloproteinases
SO IN VIVO
LA English
DT Article
DE Curcumin; acetaminophen-induced hepatotoxicity; tumor necrosis factor
   alpha; oxidative stress; matrix metalloproteinases
ID HEPATIC MICROVASCULAR INJURY; LIVER-INJURY; METABOLIC SYNDROME;
   IN-VITRO; NECROSIS; ISCHEMIA; PROTECTS; INHIBITION; ALPHA; REGENERATION
AB Background/Aim: The hepatoprotective role of various molecules in drug-induced hepatotoxicity arouses great interest. We investigated the effect of liposomal curcumin (LCC) on experimental acetaminophen (APAP)-induced hepatotoxicity. Materials and Methods: Rats were randomly allocated into 5 groups, and the effect of two LCC concentrations was studied: group 1 - 1 ml intraperitoneal (i.p.) saline, group 2 - APAP pretreatment, group 3 - APAP+silymarin (extract of the silybum marianum with anti-inflammatory, anti-oxidant, and anti-fibrotic properties), group 4 - APAP+LCC1, group 5 - APAP+LCC2. The biomarkers of oxidative stress (nitric oxide and malondialdehyde) and antioxidant status of plasma (thiols and catalase), TNF-alpha, MMP-2 and MMP-9 serum levels were evaluated. Results: An improvement in oxidative stress, antioxidant status, and TNF-alpha, MMP-2 and MMP-9 levels was obtained in groups pretreated with LCC compared to silymarin treatment, in a dose-dependent manner. Histopathological examination reinforced the results. Conclusion: Liposomal curcumin improves the oxidative stress/antioxidant balance and alleviates inflammation in experimental APAP-induced hepatotoxicity.
C1 [Dogaru, Gabriela] Iuliu Hatieganu Univ Med & Pharm, Dept Med Rehabil, Cluj Napoca, Romania.
   [Bulboaca, Adriana Elena; Boarescu, Paul Mihai] Iuliu Hatieganu Univ Med & Pharm, Dept Pathophysiol, Cluj Napoca, Romania.
   [Gheban, Dan] Iuliu Hatieganu Univ Med & Pharm, Dept Pathol Anat, Cluj Napoca, Romania.
   [Rus, Vasile] Univ Agr Sci & Vet Med, Dept Cell Biol Histol & Embryol, Calea Manastur Str 3-5, Cluj Napoca 400375, Romania.
   [Festila, Dana] Iuliu Hatieganu Univ Med & Pharm, Dept Orthodont, Cluj Napoca, Romania.
   [Sitar-Taut, Adela-Viviana] Iuliu Hatieganu Univ Med & Pharm, Dept Internal Med, Cluj Napoca, Romania.
   [Stanescu, Ioana] Iuliu Hatieganu Univ Med & Pharm, Dept Neurol, Cluj Napoca, Romania.
C3 Iuliu Hatieganu University of Medicine & Pharmacy; Iuliu Hatieganu
   University of Medicine & Pharmacy; Iuliu Hatieganu University of
   Medicine & Pharmacy; University of Agricultural Sciences & Veterinary
   Medicine Cluj Napoca; Iuliu Hatieganu University of Medicine & Pharmacy;
   Iuliu Hatieganu University of Medicine & Pharmacy; Iuliu Hatieganu
   University of Medicine & Pharmacy
RP Rus, V (corresponding author), Univ Agr Sci & Vet Med, Dept Cell Biol Histol & Embryol, Calea Manastur Str 3-5, Cluj Napoca 400375, Romania.
EM vasile.rus@usamvcluj.ro
RI Bulboacă, Adriana-Elena/AAD-7347-2020; Rus, Vasile/HAL-6488-2022;
   Gheban, Dan/AEM-1332-2022; STANESCU, IOANA CRISTINA/JVZ-1768-2024;
   Boarescu, Paul/S-2448-2017; Festila, Dana/AEO-5262-2022; Adriana-Elena,
   Bulboaca/S-8093-2017
OI Dan, Gheban/0000-0002-0755-2882; Adriana-Elena,
   Bulboaca/0000-0001-7748-382X; Rus, Vasile/0000-0003-3706-887X; STANESCU,
   IOANA CRISTINA/0000-0003-0613-9575
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NR 79
TC 19
Z9 20
U1 1
U2 11
PU INT INST ANTICANCER RESEARCH
PI ATHENS
PA EDITORIAL OFFICE 1ST KM KAPANDRITIOU-KALAMOU RD KAPANDRITI, PO BOX 22,
   ATHENS 19014, GREECE
SN 0258-851X
EI 1791-7549
J9 IN VIVO
JI In Vivo
PD MAR-APR
PY 2020
VL 34
IS 2
BP 569
EP 582
DI 10.21873/invivo.11809
PG 14
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA KS2ML
UT WOS:000518144400012
PM 32111755
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Luger, M
   Kruschitz, R
   Marculescu, R
   Haslacher, H
   Hoppichler, F
   Kallay, E
   Kienbacher, C
   Klammer, C
   Kral, M
   Langer, F
   Luger, E
   Prager, G
   Trauner, M
   Traussnigg, S
   Würger, T
   Schindler, K
   Ludvik, B
AF Luger, Maria
   Kruschitz, Renate
   Marculescu, Rodrig
   Haslacher, Helmuth
   Hoppichler, Friedrich
   Kallay, Enikoe
   Kienbacher, Christian
   Klammer, Carmen
   Kral, Melanie
   Langer, Felix
   Luger, Eva
   Prager, Gerhard
   Trauner, Michael
   Traussnigg, Stefan
   Wuerger, Tanja
   Schindler, Karin
   Ludvik, Bernhard
TI The link between obesity and vitamin D in bariatric patients with
   omega-loop gastric bypass surgery - a vitamin D supplementation trial to
   compare the efficacy of postoperative cholecalciferol loading (LOAD):
   study protocol for a randomized controlled trial
SO TRIALS
LA English
DT Article
DE Bariatric patients; Cholecalciferol; Obesity; Vitamin D; Vitamin D
   supplementation trial
ID FATTY LIVER-DISEASE; QUALITY-OF-LIFE; D DEFICIENCY; NUTRITIONAL
   DEFICIENCIES; METABOLIC SYNDROME; NONALCOHOLIC STEATOHEPATITIS;
   MORBID-OBESITY; WEIGHT-LOSS; D-RECEPTOR; DEPRESSION
AB Background: Beyond its classical role in calcium homoeostasis and bone metabolism, vitamin D deficiency has been found to be associated with several diseases, including diabetes, non-alcoholic fatty liver disease, and even obesity itself. Importantly, there are limited data on therapeutic strategies for vitamin D deficiency in bariatric patients, and the procedure-specific guidelines may not be sufficient. To improve long-term outcomes, nutritional screening and appropriate supplementation to prevent nutrient deficiencies are urgently needed. Therefore, the aim of this study is to examine effects and safety of a forced dosing regimen of vitamin D versus conventional dose supplementation on vitamin D levels and other parameters in bariatric patients.
   Methods/Design: The study includes loading plus repeat dosing compared with repeated administration of vitamin D without a loading dose, according to guidelines, in a prospective, double-blind, randomized controlled trial. Up to a triple oral loading dose is given on day 1, then 2 and 4 weeks after surgery (100,000 IU dose each time), followed by an oral maintenance dose (3420 IU/day). The control group (n = 25) will receive placebo, followed by administration of a standard dose (3420 IU/day). We hypothesize that a significant increase in vitamin D levels will occur in patients in the treatment group (n = 25) by 24 weeks after surgery. Further measurements are aimed at evaluating changes in inflammation, bone turnover, insulin resistance, blood pressure, liver, mental health, and gut microbiota of patients undergoing omega-loop gastric bypass surgery. Furthermore, possible associations between concentrations of vitamin D, the involved enzymes, or vitamin D receptor in adipose and/or liver tissues will be determined.
   Discussion: To our knowledge, this trial is the first of its kind with this type of vitamin D supplementation in bariatric patients. Its major strength is the design and implementation of evaluation of influencing factors such as liver function, bone health, inflammation, insulin resistance, blood pressure, symptoms of depression, or microbiota. This alternative vitamin D dosing regimen has the potential to be a safe, fast, evidence-based treatment of vitamin D deficiency in bariatric patients. Owing to the increasing number of bariatric patients, it is also of interest to elucidate the link between obesity and vitamin D.
C1 [Luger, Maria; Kruschitz, Renate; Klammer, Carmen; Schindler, Karin; Ludvik, Bernhard] Med Univ Vienna, Dept Internal Med 3, Div Endocrinol & Metab, A-1090 Vienna, Austria.
   [Luger, Maria; Hoppichler, Friedrich] SIPCAN, A-5026 Salzburg, Austria.
   [Marculescu, Rodrig; Haslacher, Helmuth] Med Univ Vienna, Dept Lab Med, Clin Inst Med & Chem Lab Diagnost, A-1090 Vienna, Austria.
   [Kallay, Enikoe] Med Univ Vienna, Dept Pathophysiol & Allergy Res, A-1090 Vienna, Austria.
   [Kienbacher, Christian; Kral, Melanie; Trauner, Michael; Traussnigg, Stefan] Med Univ Vienna, Dept Internal Med 3, Div Gastroenterol & Hepatol, A-1090 Vienna, Austria.
   [Langer, Felix; Prager, Gerhard] Med Univ Vienna, Dept Surg, Div Gen Surg, A-1090 Vienna, Austria.
   [Luger, Eva] Med Univ Vienna, Ctr Publ Hlth, Inst Social Med, A-1090 Vienna, Austria.
   [Wuerger, Tanja] Med Univ Vienna, Dept Pathol, A-1090 Vienna, Austria.
C3 Medical University of Vienna; Medical University of Vienna; Medical
   University of Vienna; Medical University of Vienna; Medical University
   of Vienna; Medical University of Vienna; Medical University of Vienna
RP Schindler, K (corresponding author), Med Univ Vienna, Dept Internal Med 3, Div Endocrinol & Metab, Wahringer Gurtel 18-20, A-1090 Vienna, Austria.
EM karin.schindler@meduniwien.ac.at
RI Trauner, Michael/HCH-4032-2022; Marculescu, Rodrig/B-6474-2016;
   Haslacher, Helmuth/D-4233-2013
OI Trauner, Michael/0000-0002-1275-6425; Marculescu,
   Rodrig/0000-0003-1772-6695; Wakolbinger, Maria/0000-0002-1991-6700;
   Haslacher, Helmuth/0000-0003-4605-2503; Winzer, Eva/0000-0002-5547-8517;
   Kallay, Eniko/0000-0002-4996-0104
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NR 82
TC 11
Z9 11
U1 1
U2 22
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1745-6215
J9 TRIALS
JI Trials
PD AUG 5
PY 2015
VL 16
AR 328
DI 10.1186/s13063-015-0877-9
PG 11
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA CO1MX
UT WOS:000358920600001
PM 26242295
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Garg, A
   Naik, HB
   Kirby, JS
AF Garg, Amit
   Naik, Haley B.
   Kirby, Joslyn S.
TI A Practical Guide for Primary Care Providers on Timely Diagnosis and
   Comprehensive Care Strategies for Hidradenitis Suppurativa
SO AMERICAN JOURNAL OF MEDICINE
LA English
DT Review
DE Hidradenitis suppurativa; HS clinical presentation; HS management;
   Primary care provider
ID QUALITY-OF-LIFE; METABOLIC SYNDROME; PAIN MANAGEMENT; DISEASE;
   PREVALENCE; DEPRESSION; HEALTH; BURDEN; RISK; SEVERITY
AB Hidradenitis suppurativa is a chronic, progressive inflammatory disease of the skin with many systemic implications. Hidradenitis suppurativa is frequently underdiagnosed or misdiagnosed, particularly because of heterogeneity in presentation and low disease recognition. Patients can see multiple types of health care providers, including primary care providers, along their journey to an accurate diagnosis. This review provides a comprehensive overview of the clinical presentation, associated comorbidities, and life impact associated with hidradenitis suppurativa. Disease features described here can facilitate earlier identification of hidradenitis suppurativa, differentiation from common mimickers, and timely referrals for multidisciplinary management when needed. Engagement of the medical community will also support comprehensive care strategies necessary in hidradenitis suppurativa.
C1 [Garg, Amit] Donald & Barbara Zucker Sch Med Hofstra Northwell, New Hyde Pk, NY USA.
   [Naik, Haley B.] Univ Calif San Francisco, San Francisco, CA 94143 USA.
   [Kirby, Joslyn S.] Penn State Hlth Dermatol, Hershey, PA USA.
C3 Northwell Health; University of California System; University of
   California San Francisco
RP Garg, A (corresponding author), Donald & Barbara Zucker Sch Med Hofstra Northwell, Dept Dermatol, 1991 Marcus Ave,Suite 300, New Hyde Pk, NY 11042 USA.
EM amgarg@Northwell.edu
RI Garg, Amit/JEO-9043-2023
OI Garg, Amit/0000-0003-0886-6856
FU Novartis Pharmaceuticals Corporation
FX Medical writing support was provided by Charli Dominguez, PhD, CMPP, of
   Health Interactions, Inc, Chicago, IL, and was funded by Novartis
   Pharmaceuticals Corporation. This manuscript was developed in accordance
   with Good Publication Practice (GPP3) guidelines. Authors had full
   control of the content and made the final decision on all aspects of
   this publication.
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NR 119
TC 10
Z9 10
U1 1
U2 3
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0002-9343
EI 1555-7162
J9 AM J MED
JI Am. J. Med.
PD JAN
PY 2023
VL 136
IS 1
BP 42
EP 53
DI 10.1016/j.amjmed.2022.09.025
EA DEC 2022
PG 12
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 6Z9GN
UT WOS:000898076100019
PM 36252715
OA hybrid
DA 2025-06-11
ER

PT J
AU Bansal, D
   Chahoud, G
   Smith, ES
   Mehta, JL
AF Bansal, Darpan
   Chahoud, Georges
   Smith, Eugene S.
   Mehta, Jawahar L.
TI Prevention of heart failure
SO CURRENT OPINION IN CARDIOLOGY
LA English
DT Review
DE clinical trials; heart failure; prevention
ID CORONARY-ARTERY-DISEASE; CONVERTING-ENZYME-INHIBITOR;
   MYOCARDIAL-INFARCTION; CARDIOVASCULAR EVENTS; METABOLIC SYNDROME;
   LIFETIME RISK; US MEN; DEPRESSION; OUTCOMES; TRIAL
AB Purpose of review
   Chronic heart failure imposes a significant health burden and remains a substantial and increasing problem despite advances in therapy. Hence, prevention of heart failure is a priority.
   Recent findings
   Various risk factors have been identified that contribute to development of heart failure. In this review, we will discuss the various recently reported clinical trials, epidemiological studies, meta-analyses, and subanalyses that have identified these risk factors and have provided evidence regarding the strategies to prevent heart failure.
   Summary
   Heart failure is a costly, disabling, and potentially fatal disease. It is therefore important to incorporate the strategies for prevention of heart failure on the basis of the current available evidence onto routine clinical practice.
C1 Univ Arkansas Med Sci, Div Cardiovasc Med, Dept Internal Med, Little Rock, AR 72205 USA.
   Cent Arkansas Vet Healthcare Syst, Little Rock, AR USA.
C3 University of Arkansas System; University of Arkansas Medical Sciences;
   US Department of Veterans Affairs; Veterans Health Administration (VHA);
   Central Arkansas Veterans Healthcare System
RP Chahoud, G (corresponding author), Univ Arkansas Med Sci, Div Cardiovasc Med, Dept Internal Med, 4301 W Markham,Slot 532, Little Rock, AR 72205 USA.
EM chahoudgeorges@uams.edu
RI Mehta, jl/AAB-8832-2019
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NR 47
TC 7
Z9 7
U1 0
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0268-4705
J9 CURR OPIN CARDIOL
JI Curr. Opin. Cardiol.
PD SEP
PY 2006
VL 21
IS 5
BP 510
EP 516
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 082JZ
UT WOS:000240384200013
PM 16900016
DA 2025-06-11
ER

PT J
AU Chang, YC
   Yu, YH
   Shew, JY
   Lee, WJ
   Hwang, JJ
   Chen, YH
   Chen, YR
   Wei, PC
   Chuang, LM
   Lee, WH
AF Chang, Yi-Cheng
   Yu, Yu-Hsiang
   Shew, Jin-Yuh
   Lee, Wei-Jei
   Hwang, Juey-Jen
   Chen, Yen-Hui
   Chen, Yet-Ran
   Wei, Pei-Chi
   Chuang, Lee-Ming
   Lee, Wen-Hwa
TI Deficiency of NPGPx, an oxidative stress sensor, leads to obesity in
   mice and human
SO EMBO MOLECULAR MEDICINE
LA English
DT Article
DE adipogenesis; C/EBP; N-acetylcysteine; NPGPx; oxidative stress
ID ALPHA-LIPOIC ACID; DIET-INDUCED OBESITY; BODY-MASS INDEX;
   GLUTATHIONE-PEROXIDASE; ADIPOCYTE DIFFERENTIATION; INSULIN-RESISTANCE;
   METABOLIC SYNDROME; CELL-DEATH; PROTECTS; ASSOCIATION
AB Elevated oxidative stress is closely associated with obesity. Emerging evidence shows that instead of being a consequence of obesity, oxidative stress may also contribute to fat formation. Nonselenocysteine-containing phospholipid hydroperoxide glutathione peroxidase (NPGPx) is a conserved oxidative stress sensor/transducer and deficiency of NPGPx causes accumulation of reactive oxygen species (ROS). In this communication, we show that NPGPx was highly expressed in preadipocytes of adipose tissue. Deficiency of NPGPx promoted preadipocytes to differentiate to adipocytes via ROS-dependent dimerization of protein kinase A regulatory subunits and activation of CCAA N-acetylcysteine (NAC). Consistently, NPGPx-deficient mice exhibited markedly increased fat mass and adipocyte hypertrophy, while treatment with NAC ablated these phenotypes. Furthermore, single nucleotide polymorphisms (SNPs) in human NPGPx gene, which correlated with lower NPGPx expression level in adipose tissue, were associated with higher body mass index (BMI) in several independent human populations. These results indicate that NPGPx protects against fat accumulation in mice and human via modulating ROS, and highlight the importance of targeting redox homeostasis in obesity management.
C1 [Chang, Yi-Cheng; Yu, Yu-Hsiang; Shew, Jin-Yuh; Wei, Pei-Chi; Lee, Wen-Hwa] Acad Sinica, Genom Res Ctr, Taipei 115, Taiwan.
   [Chang, Yi-Cheng] Natl Taiwan Univ, Grad Program Translat Med, Taipei 10764, Taiwan.
   [Chang, Yi-Cheng; Hwang, Juey-Jen; Chuang, Lee-Ming] Natl Taiwan Univ Hosp, Dept Internal Med, Taipei 100, Taiwan.
   [Lee, Wei-Jei] Min Sheng Gen Hosp, Dept Surg, Taoyan, Taiwan.
   [Chen, Yen-Hui] Acad Sinica, Inst Biomed Sci, Taipei 115, Taiwan.
   [Chen, Yet-Ran] Acad Sinica, Agr Biotechnol Res Ctr, Taipei 115, Taiwan.
   [Lee, Wen-Hwa] Univ Calif Irvine, Dept Biol Chem, Irvine, CA 92717 USA.
C3 Academia Sinica - Taiwan; National Taiwan University; National Taiwan
   University; National Taiwan University Hospital; Academia Sinica -
   Taiwan; Academia Sinica - Taiwan; University of California System;
   University of California Irvine
RP Lee, WH (corresponding author), Acad Sinica, Genom Res Ctr, Taipei 115, Taiwan.
EM leeming@ntu.edu.tw; whlee@uci.edu
RI Lee, Wen-Hwa/C-2519-2014; Yu, Yu-Hsiang/J-4424-2019; Chen,
   Yi-Ting/I-3161-2013; Chiang, Chieh/C-3815-2015; Chuang,
   Lee-Ming/AAF-3324-2019; Chang, Yi-Cheng/O-1334-2018
OI Wei, Pei-Chi/0000-0002-3309-0511; CHUANG, LEE-MING/0000-0003-0978-2662;
   Chen, Yet-Ran/0000-0002-2409-6655; Chang, Yi-Cheng/0000-0002-8077-5011;
   Yu, Yu-Hsiang/0000-0001-9629-8478; Hwang, Juey-Jen/0000-0001-6437-0455
FU Medical Research Council [G0000934]; Wellcome Trust [068545/Z/02]; NIH
   [R01 HL087679]; National Research Program for Biopharmaceuticals of
   Taiwan; National Science Council of Taiwan [NSC 97-2314-B-002-047-MY3];
   Academia Sinica, Taiwan; MRC [G0000934] Funding Source: UKRI
FX We acknowledge the use of genotype data from the British 1958 Birth
   Cohort DNA collection (funded by the Medical Research Council grant
   G0000934 and the Wellcome Trust grant 068545/Z/02) and the genotype data
   from the Northern Finland Birth Cohort collection (funded by the NIH
   grant R01 HL087679). We thank Dr. Dale R. Nyholt (Queensland Institute
   of Medical Research) for the help of corrections for multiple correlated
   SNPs and Dr. Pi-Hua Liu (Chang-Gung University) for the statistical
   assistance of correction for multiple correlated genetic tests. We thank
   Dr. Eva Y.-H.P. Lee (University of California, Irvine) for critical
   comments of the manuscript. We also thank the Taiwan Mouse Clinic
   (funded by the National Research Program for Biopharmaceuticals of
   Taiwan) for their technical support, the National RNAi Core Facility for
   shRNA plasmid and the Metabolomics Core of Academia Sinica for targeted
   lipidomics study. This work was mainly supported by the Academia Sinica,
   Taiwan to WHL and in part by a grant (NSC 97-2314-B-002-047-MY3) from
   the National Science Council of Taiwan to LMC The funders had no role in
   study design, data collection and analysis, decision to publish, or
   preparation of the manuscript. YHY was supported by a postdoc fellowship
   and YCC by a fellowship for Translational Medicine Graduate Program from
   the Academia Sinica, Taiwan.
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NR 46
TC 60
Z9 63
U1 0
U2 19
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1757-4676
EI 1757-4684
J9 EMBO MOL MED
JI EMBO Mol. Med.
PD AUG
PY 2013
VL 5
IS 8
BP 1165
EP 1179
DI 10.1002/emmm.201302679
PG 15
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 195QE
UT WOS:000322717900006
PM 23828861
OA Green Published
DA 2025-06-11
ER

PT J
AU Wouters, HJCM
   van Loon, HCM
   van der Klauw, MM
   Elderson, MF
   Slagter, SN
   Kobold, AM
   Kema, IP
   Links, TP
   van Vliet-Ostaptchouk, JV
   Wolffenbuttel, BHR
AF Wouters, Hanneke J. C. M.
   van Loon, Hannah C. M.
   van der Klauw, Melanie M.
   Elderson, Martin F.
   Slagter, Sandra N.
   Kobold, Anneke Muller
   Kema, Ido P.
   Links, Thera P.
   van Vliet-Ostaptchouk, Jana V.
   Wolffenbuttel, Bruce H. R.
TI No Effect of the Thr92Ala Polymorphism of Deiodinase-2 on Thyroid
   Hormone Parameters, Health-Related Quality of Life, and Cognitive
   Functioning in a Large Population-Based Cohort Study
SO THYROID
LA English
DT Article
DE TSH; free T4; general population; quality of life; deiodinase-2;
   polymorphism; executive functioning
ID TYPE-2 DEIODINASE; L-THYROXINE; COMMON VARIATION; GENE; ASSOCIATION;
   COMBINATION; THERAPY; TSH; HYPOTHYROIDISM; LEVOTHYROXINE
AB Introduction: The presence of the Thr92Ala polymorphism of deiodinase-2 (D2) has been thought to have several effects. It may influence its enzymatic function, is associated with increased expression of genes involved in oxidative stress in brain tissue, and may predict favorable response to combination levothyroxine (LT4) plus triiodothyronine (T3) therapy. It was hypothesized that homozygous carriers of the D2-92Ala allele have different thyroid hormone parameters, and reduced health-related quality of life (HRQoL) and cognitive functioning.
   Methods: In 12,625 participants from the LifeLines cohort study with genome-wide genetic data available, the effects of the Thr92Ala polymorphism (rs225014) were evaluated in the general population and in 364 people treated with thyroid hormone replacement therapy, the latter mainly because of primary hypothyroidism. In addition to evaluating anthropometric data, medication use, and existence of metabolic syndrome, HRQoL was assessed with the RAND 36-Item Health Survey, and the Ruff Figural Fluency Test was used as a sensitive test for executive functioning. Data on thyrotropin, free thyroxine (fT4), and free T3 (fT3) levels were available in a subset of 4479 participants.
   Results: The mean age (-standard deviation) was 53 +/- 12 years and the body mass index was 27.0 +/- 4.5 kg/m(2) in the LT4 users compared with 48 +/- 11 years and 26.2 +/- 4.1 kg/m(2) in participants from the general population. The Ala/Ala genotype of the D2-Thr92Ala polymorphism was present in 11.3% of LT4 users and in 10.7% of the general population. In total, 3742/4479 subjects with thyroid hormone data available had normal TSH (0.4-4.0 mIU/L), and 88% of LT4 users were females. LT4 users had higher fT4, lower fT3, and a lower fT3/fT4 ratio, and female patients had lower scores on the HRQoL domains of physical functioning, vitality, mental health, social functioning, bodily pain, and general health compared with those not using LT4 (p < 0.005). Executive functioning scores, as part of cognitive functioning, were comparable between female LT4 users and the general population. In both groups, the D2-Thr92Ala polymorphism was not associated with differences in TSH, fT4, fT3, the fT3/fT4 ratio, presence of metabolic syndrome or other comorbidities, use of medication, HRQoL, and cognitive functioning.
   Conclusion: The Thr92Ala polymorphism of D2 was not associated with thyroid parameters, HRQoL, and cognitive functioning in the general population and in participants on thyroid hormone replacement therapy.
C1 [Wouters, Hanneke J. C. M.; van Loon, Hannah C. M.; van der Klauw, Melanie M.; Elderson, Martin F.; Slagter, Sandra N.; Links, Thera P.; van Vliet-Ostaptchouk, Jana V.; Wolffenbuttel, Bruce H. R.] Univ Groningen, Univ Med Ctr Groningen, Dept Endocrinol & Metab, Groningen, Netherlands.
   [Kobold, Anneke Muller; Kema, Ido P.] Univ Groningen, Univ Med Ctr Groningen, Dept Lab Med, Groningen, Netherlands.
C3 University of Groningen; University of Groningen
RP Wolffenbuttel, BHR (corresponding author), Univ Med Ctr Groningen, Dept Endocrinol, HPC AA31,POB 30001, NL-9700 RB Groningen, Netherlands.
EM bwo@umcg.nl
RI Muller Kobold, Anna/HHC-2189-2022; van der Klauw, Melanie/A-2138-2014
OI Wolffenbuttel, Bruce H.R./0000-0001-9262-6921; Muller Kobold,
   Anneke/0000-0003-3457-4179; van Vliet-Ostaptchouk,
   Jana/0000-0002-7943-3153; van der Klauw, Melanie/0000-0001-7178-009X
FU Dutch Government; Netherlands Organization of Scientific Research NOW
   [175.010.2007.006]; Northern Netherlands Collaboration of Provinces
   (SNN); European fund for regional development; Target project;
   University of Groningen; University Medical Center Groningen,
   Netherlands; National Consortium for Healthy Ageing; European Union
   [261433]; Dutch Ministry of Economic Affairs; Pieken in de Delta;
   Province of Groningen; Province of Drenthe; BBMRI-NL
FX LifeLines has been funded by a number of public sources, notably the
   Dutch Government, The Netherlands Organization of Scientific Research
   NOW (grant 175.010.2007.006), the Northern Netherlands Collaboration of
   Provinces (SNN), the European fund for regional development, Dutch
   Ministry of Economic Affairs, Pieken in de Delta, Provinces of Groningen
   and Drenthe, the Target project, BBMRI-NL, the University of Groningen,
   and the University Medical Center Groningen, Netherlands. This work was
   supported by the National Consortium for Healthy Ageing, and funds from
   the European Union's Seventh Framework program (FP7/2007-2013) through
   the BioSHaRE-EU (Biobank Standardisation and Harmonisation for Research
   Excellence in the European Union) project, grant agreement 261433.
   LifeLines (BRIF4568) is engaged in a Bioresource research impact factor
   (BRIF) policy pilot study, details of which can be found at
   www.bioshare.eu/content/bioresource-impact-factor.
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NR 46
TC 75
Z9 78
U1 0
U2 5
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1050-7256
EI 1557-9077
J9 THYROID
JI Thyroid
PD FEB
PY 2017
VL 27
IS 2
BP 147
EP 155
DI 10.1089/thy.2016.0199
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism
GA EK6RK
UT WOS:000394051600004
PM 27786042
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Bermejo-Millo, JC
   Guimaraes, MRM
   de Luxán-Delgado, B
   Potes, Y
   Pérez-Martínez, Z
   Díaz-Luis, A
   Caballero, B
   Solano, JJ
   Vega-Naredo, I
   Coto-Montes, A
AF Carlos Bermejo-Millo, Juan
   Moreira Guimaraes, Marcela Rodrigues
   de Luxan-Delgado, Beatriz
   Potes, Yaiza
   Perez-Martinez, Zulema
   Diaz-Luis, Andrea
   Caballero, Beatriz
   Jose Solano, Juan
   Vega-Naredo, Ignacio
   Coto-Montes, Ana
TI High-Fructose Consumption Impairs the Redox System and Protein Quality
   Control in the Brain of Syrian Hamsters: Therapeutic Effects of
   Melatonin
SO MOLECULAR NEUROBIOLOGY
LA English
DT Article
DE High-fructose; Brain; ER stress; Autophagy; Neurodegeneration; Melatonin
ID GLYCATION END-PRODUCTS; ENDOPLASMIC-RETICULUM STRESS;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; OXIDATIVE STRESS;
   GLUCOSE-TOLERANCE; LIPID-METABOLISM; BLOOD-LIPIDS; RISK-FACTOR;
   URIC-ACID
AB Although numerous studies have demonstrated the harmful effect of excessive fructose consumption at the systemic level, there is little information on its effects in the central nervous system. The purpose of the present work was to study the cellular alterations related to oxidative stress and protein quality control systems induced by a high-fructose diet in the brain of Syrian hamsters and their possible attenuation by exogenous melatonin. High-fructose intake induced type II diabetes together with oxidative damage, led to alterations of the unfolded protein response by activating the eIF2 alpha branch, and impaired the macroautophagic machinery in the brain, favoring the accumulation of aggregates labeled for selective degradation and neurodegeneration markers such as beta-amyloid (1-42), tau-p-S199, and tau-p-S404. Melatonin attenuated the manifestation of type II diabetes and reduced oxidative stress, deactivated eIF2 alpha, and decreased tau-p-S404 levels in the brain of animals fed a high-fructose diet.
C1 [Carlos Bermejo-Millo, Juan; Moreira Guimaraes, Marcela Rodrigues; de Luxan-Delgado, Beatriz; Potes, Yaiza; Perez-Martinez, Zulema; Diaz-Luis, Andrea; Caballero, Beatriz; Vega-Naredo, Ignacio; Coto-Montes, Ana] Univ Oviedo, Fac Med, Dept Morphol & Cell Biol, E-33006 Oviedo, Spain.
   [Carlos Bermejo-Millo, Juan; Potes, Yaiza; Perez-Martinez, Zulema; Diaz-Luis, Andrea; Caballero, Beatriz; Jose Solano, Juan; Vega-Naredo, Ignacio; Coto-Montes, Ana] IISPA, Oviedo 33011, Spain.
   [Perez-Martinez, Zulema] Univ Cent Hosp Asturias, Serv Microbiol, Oviedo 33011, Spain.
C3 University of Oviedo; Instituto de Investigacion Sanitaria del
   Principado de Asturias (ISPA)
RP Vega-Naredo, I (corresponding author), Univ Oviedo, Fac Med, Dept Morphol & Cell Biol, E-33006 Oviedo, Spain.; Vega-Naredo, I (corresponding author), IISPA, Oviedo 33011, Spain.
EM naredo@gmail.com
RI Vega-Naredo, Ignacio/A-4245-2009; Luxán-Delgado, Beatriz/AAC-8452-2020;
   Potes, Yaiza/AAU-2188-2021; Caballero García, Beatriz/AAC-2636-2020;
   coto-montes, ana/D-2544-2016
OI Vega-Naredo, Ignacio/0000-0003-1993-6725; Luxan-Delgado,
   Beatriz/0000-0003-4507-716X; Caballero Garcia,
   Beatriz/0000-0003-0242-9620; Potes, Yaiza/0000-0002-4687-6230
FU Instituto de Salud Carlos III (Spanish Ministry of Economy and
   Competitiveness) [RD12/0043/0030, RD12/0043/0017, PI13/02741,
   PI17/02009, FI14/00405]; Government of the Principality of Asturias
   [GRUPIN14-071]; European Regional Development Fund; AINDACE (Ayuda a la
   Investigacion del Dano Cerebral) foundation (Spain); PUEDES Program
   (European Commission) [2013-2586/001-001-EMA2]
FX This work was supported by the Instituto de Salud Carlos III (Spanish
   Ministry of Economy and Competitiveness) under grants RD12/0043/0030,
   RD12/0043/0017, PI13/02741 and PI17/02009; and the Government of the
   Principality of Asturias under grant GRUPIN14-071, all of them
   co-financed by the European Regional Development Fund. J.C.B.M.
   acknowledges his MSc thesis award from AINDACE (Ayuda a la Investigacion
   del Dano Cerebral) foundation (Spain). M.R.M.G acknowledges her
   postdoctoral fellowship (2013-2586/001-001-EMA2) from the PUEDES Program
   (European Commission). Y.P. acknowledges her predoctoral fellow
   (FI14/00405) from the Instituto de Salud Carlos III (Spanish Ministry of
   Economy and Competitiveness).
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NR 69
TC 13
Z9 13
U1 0
U2 11
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0893-7648
EI 1559-1182
J9 MOL NEUROBIOL
JI Mol. Neurobiol.
PD OCT
PY 2018
VL 55
IS 10
BP 7973
EP 7986
DI 10.1007/s12035-018-0967-2
PG 14
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA GT1FX
UT WOS:000444207800026
PM 29492847
DA 2025-06-11
ER

PT J
AU Fernández-Iglesias, A
   Pajuelo, D
   Quesada, H
   Díaz, S
   Bladé, C
   Arola, L
   Salvadó, MJ
   Mulero, M
AF Fernandez-Iglesias, Anabel
   Pajuelo, David
   Quesada, Helena
   Diaz, Sabina
   Blade, Cinta
   Arola, Lluis
   Josepa Salvado, Maria
   Mulero, Miquel
TI Grape seed proanthocyanidin extract improves the hepatic glutathione
   metabolism in obese Zucker rats
SO MOLECULAR NUTRITION & FOOD RESEARCH
LA English
DT Article
DE Liver; Glutathione; Oxidative Stress; Proanthocyanidins; Zucker fatty
   rats
ID OXIDATIVE STRESS; PROCYANIDIN EXTRACT; MITOCHONDRIAL-FUNCTION;
   ANTIOXIDANT CAPACITY; ADIPOSE-TISSUE; FA/FA RATS; IN-VITRO; LEPTIN;
   ACID; INFLAMMATION
AB ScopeIncreased oxidative stress may play an important role in metabolic syndrome and related manifestations, including obesity, atherosclerosis, hypertension, and insulin resistance. Its relation to obesity is due to increased reactive oxygen species and/or decreased glutathione (GSH) antioxidant metabolism. Consequently, the activation of glutathione metabolism appears to be a central defense response to prevent oxidative stress. In this sense, dietary supplements with natural antioxidant molecules, including proanthocyanidins, may present a useful strategy of controlling and reducing complications of obesity, including hepatic steatosis.
   Materials and resultsWe assessed the grape seed proanthocyanidin extract (GSPE) effect on oxidative alterations related to genetically obese rats (Zucker rats) and, more specifically, to hepatic GSH metabolism. We demonstrate that the administration of GSPE reduced the oxidized glutathione accumulation increasing the total GSH/oxidized glutathione hepatic ratio and consequently decreasing the activation of antioxidant enzymes, including glutathione peroxidase, glutathione reductase, and glutathione S-transferase, and increasing the total antioxidant capacity of the cell.
   ConclusionIn Zucker rats, the obesity-induced oxidative stress related to liver glutathione alteration was mitigated by GSPE administration.
C1 [Fernandez-Iglesias, Anabel; Pajuelo, David; Quesada, Helena; Diaz, Sabina; Blade, Cinta; Arola, Lluis; Josepa Salvado, Maria; Mulero, Miquel] Univ Rovira & Virgili, Dept Bioquim & Biotecnol, Grp Nutrigen, E-43007 Tarragona, Spain.
C3 Universitat Rovira i Virgili
RP Mulero, M (corresponding author), Univ Rovira & Virgili, Dept Bioquim & Biotecnol, Grp Nutrigen, Campus Sescelades,Marcel Li Domingo S-N, E-43007 Tarragona, Spain.
EM miquel.mulero@urv.cat
RI Fernández-Iglesias, Anabel/AAD-6811-2020; Vázquez, Helena/AAC-2695-2021;
   Pajuelo Reguera, David/G-3814-2014; Arola, Lluis/C-6074-2011; Mulero,
   Miquel/L-4672-2014; Fernandez-Iglesias, Anabel/K-2285-2015; SALVADO,
   JOSEPA/B-6062-2015
OI Pajuelo Reguera, David/0000-0002-7715-9402; Blade,
   Cinta/0000-0003-2838-2402; Arola, Lluis/0000-0003-2767-1974; Mulero,
   Miquel/0000-0003-2545-2065; Fernandez-Iglesias,
   Anabel/0000-0003-2364-6675; SALVADO, JOSEPA/0000-0003-3883-3326
FU FPI from the "Ministerio de Economia y Competitividad (MINECO)" for
   Ph.D. students; MINECO of the Spanish Government [AGL2008-00387/ALI]
FX The present study was supported by a grant FPI from the "Ministerio de
   Economia y Competitividad (MINECO)" for Ph.D. students and a grant from
   the MINECO AGL2008-00387/ALI of the Spanish Government.
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NR 52
TC 33
Z9 38
U1 2
U2 39
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1613-4125
EI 1613-4133
J9 MOL NUTR FOOD RES
JI Mol. Nutr. Food Res.
PD APR
PY 2014
VL 58
IS 4
BP 727
EP 737
DI 10.1002/mnfr.201300455
PG 11
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA AF2DA
UT WOS:000334521600008
PM 24338985
DA 2025-06-11
ER

PT J
AU Hernández, J
   Muiño, R
   Benedito, JL
   Abuelo, A
   Castillo, C
AF Hernandez, Joaquin
   Muino, Rodrigo
   Benedito, Jose L.
   Abuelo, A.
   Castillo, Cristina
TI Redox status and oxidative stress in bovine
SO LARGE ANIMAL REVIEW
LA English
DT Article
DE ROS; redox status; internal metabolism; cattle
ID BODY CONDITION SCORE; DAIRY-COWS; CORPUS-LUTEUM; ASSOCIATION; ROLES
AB In the last few years, we have seen a marked increase in the number of articles emphasizing the role of oxidative stress in the pathogenesis of multiple cattle diseases and processes. Since the term oxidative stress (OS), defined as the imbalance between prooxidants and antioxidants, was coined, the physiological and pathological roles of both have also been described. This has shown that understanding the relationship between the two components, known as redox status, is a very useful tool in establishing the health and disease status of cattle. OS has been related to production diseases, metabolic diseases - such as ketosis, fatty liver, and even hypocalcaemia - and reproductive diseases. These include both maternal diseases - like those connected with numerous pathologies such as placental retention, udder oedema, or mastitis - and foetal growth. Finally, the term metabolic stress has been established. It relates OS itself to lipomobilization and immune system dysfunction, similar to the so-called metabolic syndrome in humans. Metabolic stress describes the catabolic response to the alteration of physiological homeostasis and is characterized by excessive lipid mobilization, immune and inflammatory dysfunction, and OS.
C1 [Hernandez, Joaquin; Muino, Rodrigo; Benedito, Jose L.; Castillo, Cristina] Univ Santiago de Compostela, Fac Vet, Dept Anim Pathol, Santiago De Compostela, Spain.
   [Abuelo, A.] Michigan State Univ, Coll Vet Sci, Dept Large Anim Clin Sci, E Lansing, MI 48824 USA.
C3 Universidade de Santiago de Compostela; Michigan State University
RP Hernández, J (corresponding author), Univ Santiago de Compostela, Fac Vet, Dept Anim Pathol, Santiago De Compostela, Spain.
EM joaquin.hernandez@usc.es
RI Muiño Otero, Rodrigo/GRY-6734-2022; Abuelo, Ángel/E-9349-2012; Hernandez
   Bermudez, Joaquin/H-2679-2012; Castillo Rodriguez, Cristina/H-2393-2012
OI Hernandez Bermudez, Joaquin/0000-0002-2588-0089; Castillo Rodriguez,
   Cristina/0000-0002-2467-6406
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NR 35
TC 2
Z9 2
U1 0
U2 2
PU SIVAR-SOC ITALIANA VETERINARI ANIMALI REDDITO
PI CREMONA
PA VIA TRECCHI 20, CREMONA, 26100, ITALY
SN 1124-4593
J9 LARGE ANIM REV
JI Large Anim. Rev.
PD JUN
PY 2022
VL 28
IS 3
BP 145
EP 151
PG 7
WC Agriculture, Dairy & Animal Science
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture
GA A0HB2
UT WOS:000952013700006
DA 2025-06-11
ER

PT J
AU Alciati, A
   Caldirola, D
   Grassi, M
   Foschi, D
   Perna, G
AF Alciati, Alessandra
   Caldirola, Daniela
   Grassi, Massimiliano
   Foschi, Diego
   Perna, Giampaolo
TI Mediation effect of recent loss events on weight gain in obese people
   who experienced childhood parental death or separation
SO JOURNAL OF HEALTH PSYCHOLOGY
LA English
DT Article
DE childhood trauma; obesity; prior trauma; weight gain
ID STRESSFUL LIFE EVENTS; BODY-MASS INDEX; METABOLIC SYNDROME; MAJOR
   DEPRESSION; RISK-FACTORS; PSYCHOPATHOLOGY; ABUSE; MALTREATMENT;
   DISORDER; ADULTS
AB Adverse events during childhood, including loss of a parent, are related to a higher risk of adult obesity. We investigated whether childhood parental loss is related to adult rapid weight gain through exposition to a later loss event. We assessed the mediation effect of recent loss and non-loss events on the association between childhood loss and rapid weight gain in 138 individuals seeking bariatric surgery. Our results showed that recent loss events mediate the effect of childhood parental loss on rapid weight gain (0.790; p<.001), suggesting the need for specific programs to prevent and treat obesity in individuals with multiple losses.
C1 [Alciati, Alessandra; Caldirola, Daniela; Grassi, Massimiliano; Perna, Giampaolo] FoRiPsi, Hermanas Hosp, Villa San Benedetto Hosp, Via Roma 16, I-22032 Albese Con Cassano, Como, Italy.
   [Foschi, Diego] L Sacco Univ Hosp, Milan, Italy.
   [Perna, Giampaolo] Maastricht Univ, Maastricht, Netherlands.
   [Perna, Giampaolo] Univ Miami, Coral Gables, FL 33124 USA.
C3 University of Milan; Luigi Sacco Hospital; Maastricht University;
   University of Miami
RP Alciati, A (corresponding author), FoRiPsi, Hermanas Hosp, Villa San Benedetto Hosp, Via Roma 16, I-22032 Albese Con Cassano, Como, Italy.
EM alessandra.alciati@libero.it
RI Alciati, Alessandra/M-2298-2019; Foschi, Diego/K-7248-2017; Perna,
   Giampaolo/K-5194-2013
OI Alciati, Alessandra/0000-0002-8971-4696; Foschi,
   Diego/0000-0002-7702-8226; Perna, Giampaolo/0000-0002-8166-0785;
   Caldirola, Daniela/0000-0002-1461-9475
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NR 55
TC 2
Z9 2
U1 0
U2 9
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1359-1053
EI 1461-7277
J9 J HEALTH PSYCHOL
JI J. Health Psychol.
PD JAN
PY 2017
VL 22
IS 1
BP 101
EP 110
DI 10.1177/1359105315595451
PG 10
WC Psychology, Clinical
WE Social Science Citation Index (SSCI)
SC Psychology
GA EH0QE
UT WOS:000391468000009
PM 26268512
DA 2025-06-11
ER

PT J
AU Nair, PC
   Chalker, JM
   McKinnon, RA
   Langmead, CJ
   Gregory, KJ
   Bastiampillai, T
AF Nair, Pramod C.
   Chalker, Justin M.
   McKinnon, Ross A.
   Langmead, Christopher J.
   Gregory, Karen J.
   Bastiampillai, Tarun
TI Trace Amine-Associated Receptor 1 (TAAR1): Molecular and Clinical
   Insights for the Treatment of Schizophrenia and Related Comorbidities
SO ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE
LA English
DT Article
DE trace amines; antipsychotics; ulotaront; molecular dynamics;
   treatment-resistant schizophrenia; depression
ID PHARMACOLOGY; ACTIVATION; CAPACITY
AB Schizophrenia is a complex and severe mental illness. Current treatments for schizophrenia typically modulate dopaminergic neurotransmission by D2-receptor blockade. While reducing positive symptoms of schizophrenia, current antipsychotic drugs have little clinical effect on negative symptoms and cognitive impairments. For the last few decades, discovery efforts have sought nondopaminergic compounds with the aim to effectively treat the broad symptoms of schizophrenia. In this viewpoint, we provide an overview on trace amine associated receptor-1 (TAAR1), which presents a clinically validated nondopaminergic target for treating schizophrenia and related disorders, with significantly less overall side-effect burden. TAAR1 agonists may also be specifically beneficial for the substance abuse comorbidity and metabolic syndrome that is often present in patients with schizophrenia.
C1 [Chalker, Justin M.] Flinders Univ S Australia, Inst Nanoscale Sci & Technol, Coll Sci & Engn, Adelaide, SA 5042, Australia.
   [Nair, Pramod C.; McKinnon, Ross A.] Flinders Univ S Australia, Coll Med & Publ Hlth, Flinders Hlth & Med Res Inst FHMRI, Adelaide, SA 5042, Australia.
   [Langmead, Christopher J.; Gregory, Karen J.] Monash Univ, Monash Inst Pharmaceut Sci, Drug Discovery Biol & Neurosci & Mental Hlth Ther, Parkville, Vic 3052, Australia.
   [Bastiampillai, Tarun] Monash Univ, Dept Psychiat, Clayton, Vic 3168, Australia.
   [Bastiampillai, Tarun] Flinders Univ S Australia, Coll Med & Publ Hlth, Adelaide, SA 5042, Australia.
   [Nair, Pramod C.] Flinders Univ S Australia, Coll Med & Publ Hlth, Discipline Clin Pharmacol, Adelaide, SA 5042, Australia.
C3 Flinders University South Australia; Flinders University South
   Australia; Monash University; Monash University; Flinders University
   South Australia; Flinders University South Australia
RP Nair, PC (corresponding author), Flinders Univ S Australia, Coll Med & Publ Hlth, Flinders Hlth & Med Res Inst FHMRI, Adelaide, SA 5042, Australia.; Nair, PC (corresponding author), Flinders Univ S Australia, Coll Med & Publ Hlth, Discipline Clin Pharmacol, Adelaide, SA 5042, Australia.
EM pramod.nair@flinders.edu.au
RI McKinnon, Ross/B-9340-2009; Chalker, Justin/E-6965-2011; Bastiampillai,
   Tarun/ABD-9238-2021
OI Chalker, Justin/0000-0002-7504-5508; Bastiampillai,
   Tarun/0000-0002-6931-2913; Nair, Pramod/0000-0002-8630-0121; McKinnon,
   Ross/0000-0002-3725-793X; Langmead, Christopher/0000-0003-3483-1120
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NR 19
TC 18
Z9 19
U1 0
U2 4
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
EI 2575-9108
J9 ACS PHARMACOL TRANSL
JI ACS Pharmacol. Transl. Sci.
PD MAR 11
PY 2022
VL 5
IS 3
BP 183
EP 188
DI 10.1021/acsptsci.2c00016
PG 6
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Emerging Sources Citation Index (ESCI)
SC Pharmacology & Pharmacy
GA ZU7YC
UT WOS:000770054900007
PM 35311018
OA Green Published
DA 2025-06-11
ER

PT J
AU Delbosc, S
   Paizanis, E
   Magous, R
   Araiz, C
   Dimo, T
   Cristol, JP
   Cros, G
   Azay, J
AF Delbosc, S
   Paizanis, E
   Magous, R
   Araiz, C
   Dimo, T
   Cristol, JP
   Cros, G
   Azay, J
TI Involvement of oxidative stress and NADPH oxidase activation in the
   development of cardiovascular complications in a model of insulin
   resistance, the fructose-fed rat
SO ATHEROSCLEROSIS
LA English
DT Article
DE oxidative stress; NADPH oxidase; insulin-resistance; cardiovascular
   remodeling; hypertension; fructose-fed rat
ID ENHANCED SUPEROXIDE-PRODUCTION; ANGIOTENSIN-II; CARDIAC-HYPERTROPHY;
   NADH/NADPH OXIDASE; NAD(P)H OXIDASE; HYPERTENSION; SYSTEM; DYSFUNCTION;
   PROGRESSION; PRODUCTS
AB Growing evidences suggest a role of oxidative stress in hypertension and cardiac hypertrophy. The fructose (60%)-fed rat represents a model of metabolic syndrome, associating insulin resistance and high blood pressure. In this model, hypertension, cardiac and vessels hypertrophy and markers of oxidative stress were determined. In addition, the production of reactive oxygen species (ROS) was evaluated at different times after the initiation of fructose-enriched diet in aorta, heart and polymorphonuclear cells. High fructose feeding was associated with an early (1-week) increase in ROS production by aorta, heart and circulatory polymorphonuclear cells, in association with enhanced markers of oxidative stress. Vascular and cardiac hypertrophy was also rapidly observed, while the rise in blood pressure was significant only after 3 weeks. In summary, our study suggests that the production of reactive oxygen species can be a key-event in the initiation and development of cardiovascular complications associated with insulin resistance. (c) 2004 Elsevier Ireland Ltd. All rights reserved.
C1 Inst Univ Rech Clin, Lab Nutr Humaine & Atherogenese, F-34093 Montpellier, France.
   INSERM, Lab Pharmacol & Physiopathol Expt, U376, Fac Pharm, F-34093 Montpellier, France.
C3 Universite de Montpellier; Universite de Montpellier; Institut National
   de la Sante et de la Recherche Medicale (Inserm)
RP Hop Lapeyronie, Biochem Lab, 371 Av Doyen Gaston Giraud, F-34295 Montpellier, France.
EM jp-cristol@chu-montpellier.fr
RI DELBOSC, Sandrine/ABB-4618-2021
OI , Jean-Paul Cristol/0000-0001-8563-7278; Azay-Milhau,
   Jacqueline/0000-0001-9965-9996; Delbosc, Sandrine/0000-0001-8076-6927
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NR 40
TC 192
Z9 221
U1 0
U2 8
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0021-9150
EI 1879-1484
J9 ATHEROSCLEROSIS
JI Atherosclerosis
PD MAR
PY 2005
VL 179
IS 1
BP 43
EP 49
DI 10.1016/j.atherosclerosis.2004.10.018
PG 7
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 905ME
UT WOS:000227571700005
PM 15721008
DA 2025-06-11
ER

PT J
AU Sakurai, T
   Izawa, T
   Kizaki, T
   Ogasawara, JE
   Shirato, K
   Imaizumi, K
   Takahashi, K
   Ishida, H
   Ohno, H
AF Sakurai, Takuya
   Izawa, Tetsuya
   Kizaki, Takako
   Ogasawara, Jun-Etsu
   Shirato, Ken
   Imaizumi, Kazuhiko
   Takahashi, Kazuto
   Ishida, Hitoshi
   Ohno, Hideki
TI Exercise training decreases expression of inflammation-related
   adipokines through reduction of oxidative stress in rat white adipose
   tissue
SO BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
LA English
DT Article
DE Exercise training; White adipose tissue; Oxidative stress;
   Inflammation-related adipokines; Superoxide dismutase; NADPH oxidase
ID NECROSIS-FACTOR-ALPHA; MONOCYTE CHEMOATTRACTANT PROTEIN-1;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; EPIDIDYMAL ADIPOCYTES;
   SUPEROXIDE-DISMUTASE; NOX FAMILY; OBESITY; PATHOPHYSIOLOGY
AB Increased oxidative stress in adipocytes causes dysregulated expression of inflammation-related adipokines. We have examined the effects of exercise training on oxidative stress in rat white adipose tissue (WAT), especially focusing on inflammation-related adipokines. The levels of lipid peroxidation in WAT of exercise-trained (TR) rats were lower than those ill Control (C) rats. The content of manganese-containing Superoxide dismutase in WAT of TR rats was increased as compared with those in C rats. In contrast, the expression of the NADPH oxidase NOX2 protein in WAT was downregulated by exercise training. Moreover, the levels of inflammation-related adipokines, Such as tumor necrosis factor-alpha and monocyte chemoattractant protein-1, in WAT of TR rats were lower than those in C rats. The effects of exercise training were more remarkable in visceral WAT than in subcutaneous. These results Suggest that exercise training decreases the expression of inflammation-related adipokines by reducing oxidative stress in WAT. (C) 2008 Elsevier Inc. All rights reserved.
C1 [Sakurai, Takuya; Kizaki, Takako; Ogasawara, Jun-Etsu; Shirato, Ken; Ohno, Hideki] Kyorin Univ, Sch Med, Dept Mol Predict Med & Sport Sci, Tokyo 1818611, Japan.
   [Imaizumi, Kazuhiko] Waseda Univ, Fac Human Sci, Lab Physiol Sci, Tokorozawa, Saitama 3591192, Japan.
   [Izawa, Tetsuya] Doshisha Univ, Fac Hlth & Sport Sci, Kyoto 6100394, Japan.
   [Takahashi, Kazuto; Ishida, Hitoshi] Kyorin Univ, Sch Med, Dept Internal Med 3, Tokyo 1818611, Japan.
C3 Kyorin University; Waseda University; Doshisha University; Kyorin
   University
RP Sakurai, T (corresponding author), Kyorin Univ, Sch Med, Dept Mol Predict Med & Sport Sci, 6-20-2 Shinkawa, Tokyo 1818611, Japan.
EM sakutaku@kyorin-u.ac.jp
OI Izawa, Tetsuya/0000-0001-5197-9085
FU Ministry of Education, Culture, Sport, Science and Technology of Japan;
   Nakatomi Foundation, Tokyo, Japan; Grants-in-Aid for Scientific Research
   [21300237] Funding Source: KAKEN
FX This work was partially supported by Grants-in-Aid for Specific Project
   Research from the Ministry of Education, Culture, Sport, Science and
   Technology of Japan. We are also grateful for financial Support from the
   Nakatomi Foundation, Tokyo, Japan.
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NR 25
TC 49
Z9 61
U1 1
U2 7
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0006-291X
EI 1090-2104
J9 BIOCHEM BIOPH RES CO
JI Biochem. Biophys. Res. Commun.
PD FEB 6
PY 2009
VL 379
IS 2
BP 605
EP 609
DI 10.1016/j.bbrc.2008.12.127
PG 5
WC Biochemistry & Molecular Biology; Biophysics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics
GA 401FF
UT WOS:000262924300084
PM 19121629
DA 2025-06-11
ER

PT J
AU Onumah, N
   Kircik, LH
AF Onumah, Neh
   Kircik, Leon H.
TI Psoriasis and Its Comorbidities
SO JOURNAL OF DRUGS IN DERMATOLOGY
LA English
DT Article
ID METABOLIC SYNDROME; ARTHRITIS; RISK; DEPRESSION; MORTALITY; PREVALENCE;
   MORBIDITY; FATIGUE; DISEASE
AB Psoriasis is a multi-systemic chronic inflammatory skin disease targeting 2% to 3% of the general population. It is a prototype of immune dysregulation mediated by TH1 proinflammatory cytokines such as TNF-alpha, IFN-Y, IL-6, and IL-12, to name a few. Psoriasis, traditionally viewed as an inflammatory skin disorder of unknown origin, is increasingly recognized as an inflammatory skin disease with far reaching systemic effects. There is growing and emerging evidence that psoriasis patients have a higher prevalence of associated comorbid disease with cardiometabolic dysfunction and psoriatic arthritis being at the forefront. It appears that psoriatic skin disease severity portends a serious risk for development of these comorbidities. As such, patients with moderate to severe psoriatic skin disease are found to have a higher association with these extracutaneous disease manifestations.
C1 [Onumah, Neh] Graves Dermacare Ctr PC, Philadelphia, PA USA.
   [Kircik, Leon H.] Mt Sinai Med Ctr, New York, NY 10029 USA.
   [Kircik, Leon H.] Indiana Univ Sch Med, Indianapolis, IN USA.
C3 Icahn School of Medicine at Mount Sinai; Indiana University System;
   Indiana University Bloomington
RP Onumah, N (corresponding author), Phys Skin Care, 1169 Eastern Pkwy,Ste 2310, Louisville, KY 40217 USA.
EM wedoderm@yahoo.com
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NR 33
TC 45
Z9 49
U1 0
U2 3
PU JOURNAL OF DRUGS IN DERMATOLOGY
PI NEW YORK
PA 377 PARK AVE SOUTH, 6TH FLOOR, NEW YORK, NY 10016 USA
SN 1545-9616
J9 J DRUGS DERMATOL
JI J. Drugs Dermatol.
PD MAY
PY 2012
VL 11
IS 5
SU S
BP S5
EP S10
PG 6
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 936ZE
UT WOS:000303628000002
PM 22644770
DA 2025-06-11
ER

PT J
AU Narasimhan, S
   Gokulakrishnan, K
   Sampathkumar, R
   Farooq, S
   Ravikumar, R
   Mohan, V
   Balasubramanyam, M
AF Narasimhan, Sandhya
   Gokulakrishnan, Kuppan
   Sampathkumar, Rangasamy
   Farooq, Syed
   Ravikumar, Radhakrishnan
   Mohan, Viswanathan
   Balasubramanyam, Muthuswamy
TI Oxidative stress is independently associated with non-alcoholic fatty
   liver disease (NAFLD) in subjects with and without type 2 diabetes
SO CLINICAL BIOCHEMISTRY
LA English
DT Article
DE NAFLD; Oxidative stress; Type 2 diabetes; Glutathione; Asian Indians
ID INSULIN-RESISTANCE; LIPID-PEROXIDATION; METABOLIC SYNDROME; HEPATIC
   STEATOSIS; RISK-FACTORS; FOLLOW-UP; STEATOHEPATITIS; PREVALENCE; OXYGEN;
   LIPOTOXICITY
AB Objective: Our work is aimed at exploring the interrelationship of oxidative stress and insulin resistance in NAFLD subjects with and without type 2 diabetes in a population-based study.
   Methods: Subjects [n = 200] were recruited from the Chennai Urban Rural Epidemiology Study. 1: Normal glucose tolerance (NGT) subjects without NAFLD; 2: NGT with NAFLD; 3: type 2 diabetic subjects [T2DM] without NAFLD and 4: T2DM with NAFLD. Thiobarbituric acid reactive substances (TBARS), protein carbonyl (PCC) and glutathione levels were measured by standard methods. Ultrasound of the liver was used to diagnose NAFLD.
   Results: TBARS and PCC levels were significantly elevated and GSH/GSSG ratio was significantly decreased in diabetic subjects with NAFLD compared to all other groups (p trend <0.001). Oxidative stress markers significantly associated with NAFLD even after adjusting for age, gender, BMI and glycemic status.
   Conclusions: Increased oxidative stress is independently associated with NAFLD in Asian Indians without and with T2DM. (c) 2010 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
C1 [Balasubramanyam, Muthuswamy] Madras Diabet Res Fdn, Dept Cell & Mol Biol, Madras 600086, Tamil Nadu, India.
   Dr Mohans Diabet Special Ctr, Chennai, Tamil Nadu, India.
C3 Madras Diabetes Research Foundation
RP Balasubramanyam, M (corresponding author), Madras Diabet Res Fdn, Dept Cell & Mol Biol, Madras 600086, Tamil Nadu, India.
EM balusignal@gmail.com
RI Viswanathan, Mohan/C-2321-2009; GOKULAKRISHNAN, KUPPAN/AAT-3244-2020;
   Syed, Farooq/AAK-6781-2020; /B-7510-2009
OI SYED, FAROOQ/0000-0002-0284-0631; /0000-0003-3952-4672; Mohan,
   Viswanathan/0000-0001-5038-6210; GOKULAKRISHNAN,
   KUPPAN/0000-0003-3167-8239; Rangasamy, Sampath/0000-0003-2151-9162
FU Chennai Willingdon Corporate Foundation, Chennai; DBT; DST-FIST, the
   Government of India; Lady Tata Memorial Trust
FX We are grateful to the Chennai Willingdon Corporate Foundation, Chennai
   for the financial support provided for the study. We thank the
   epidemiology team members for conducting the CURES field studies. This
   is the 89th publication of CURES [CURES-89]. Financial assistance from
   DBT and DST-FIST, the Government of India is greatly acknowledged. SN
   also acknowledges the financial assistance from the Lady Tata Memorial
   Trust.
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NR 48
TC 98
Z9 111
U1 1
U2 15
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0009-9120
EI 1873-2933
J9 CLIN BIOCHEM
JI Clin. Biochem.
PD JUL
PY 2010
VL 43
IS 10-11
BP 815
EP 821
DI 10.1016/j.clinbiochem.2010.04.003
PG 7
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA 615KD
UT WOS:000279133100004
PM 20398645
DA 2025-06-11
ER

PT J
AU Pietrzak, A
   Chodorowska, G
   Jazienicka, I
   Osemlak, P
   Wawrzycki, B
   Terlecki, P
   Mieczkowska, J
   Mosiewicz, J
   Zubilewicz, T
   Szubstarski, F
   Krupski, W
   Hercogova, J
   Szepietowski, JC
   Lotti, T
AF Pietrzak, Aldona
   Chodorowska, Grazyna
   Jazienicka, Iwona
   Osemlak, Pawel
   Wawrzycki, Bartlomiej
   Terlecki, Piotr
   Mieczkowska, Jolanta
   Mosiewicz, Jerzy
   Zubilewicz, Tomasz
   Szubstarski, Franciszek
   Krupski, Witold
   Hercogova, Jana
   Szepietowski, Jacek C.
   Lotti, Torello
TI Psoriatic erythroderma coexisting with erythema multiforme-like lesions
   induced by retinoids or retinoids combined with an antibiotic: case
   report
SO DERMATOLOGIC THERAPY
LA English
DT Article
DE erythema multiforme-like lesions; erytroderma; psoriasis; treatment
AB Psoriasis is currently considered a multifactorial disease, which can coexist with many somatic and psychological disorders. We present the case of a 50-year-old woman referred to our department due to erythroderma with concomitant peculiar violaceous, polycyclic lesions most likely induced by medications. Past medical history revealed numerous systemic disorders, including metabolic syndrome, hypertension, cardiac insufficiency, obesity, and depression. Additional examinations and consultations demonstrated dyslipidemia, xanthelasma, incomplete block of the right branch of His bundle, thyreocardiac syndrome, benign adrenal tumor, and delusions. Recently, psoriasis has been intensively studied. We present the case in which erythroderma was most likely triggered by acitretin combined with ceftriaxone. Treatment of many diseases and psychiatric disturbances coexisting with psoriasis is extremely difficult and requires cooperation of various specialists.
C1 [Pietrzak, Aldona; Chodorowska, Grazyna; Jazienicka, Iwona; Wawrzycki, Bartlomiej] Med Univ Lublin, Dept Dermatol Venereol & Pediat Dermatol, PL-20080 Lublin, Poland.
   [Osemlak, Pawel] Med Univ Lublin, Dept Pediat Surg & Traumatol, PL-20080 Lublin, Poland.
   [Terlecki, Piotr; Zubilewicz, Tomasz] Med Univ Lublin, Dept Vasc Surg & Angiol, PL-20080 Lublin, Poland.
   [Mieczkowska, Jolanta; Mosiewicz, Jerzy] Med Univ Lublin, Dept Internal Dis, PL-20080 Lublin, Poland.
   [Krupski, Witold] Med Univ Lublin, Dept Radiol 2, PL-20080 Lublin, Poland.
   [Szubstarski, Franciszek] 1st Mil Hosp, Dept Pathomorphol, Lublin, Poland.
   [Szepietowski, Jacek C.] Wroclaw Med Univ, Dept Dermatol Venereol & Allergol, Wroclaw, Poland.
   [Hercogova, Jana] Charles Univ Prague, Fac Med 2, Dept Dermatol, Prague, Czech Republic.
   [Lotti, Torello] Univ Rome G Marconi, Dept Dermatol & Venereol 2, Rome, Italy.
C3 Medical University of Lublin; Medical University of Lublin; Medical
   University of Lublin; Medical University of Lublin; Medical University
   of Lublin; Wroclaw Medical University; Motol University Hospital;
   Charles University Prague; Guglielmo Marconi University
RP Pietrzak, A (corresponding author), Med Univ Lublin, Dept Dermatol Venereol & Pediat Dermatol, Radziwillowska 13, PL-20080 Lublin, Poland.
EM aldonkapietrzak@tlen.pl
RI Wawrzycki, Bartek/ABC-2803-2020; Chodorowska, Grazyna/A-2415-2019
OI Pietrzak, Aldona/0000-0001-9494-6160; Szepietowski,
   Jacek/0000-0003-0766-6342; Wawrzycki, Bartlomiej/0000-0002-2172-701X;
   Chodorowska, Grazyna/0000-0002-8055-5764; Mosiewicz,
   Jerzy/0000-0003-0320-1863
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NR 16
TC 3
Z9 3
U1 0
U2 11
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1396-0296
EI 1529-8019
J9 DERMATOL THER
JI Dermatol. Ther.
PD NOV-DEC
PY 2011
VL 24
IS 6
BP 587
EP 590
DI 10.1111/j.1529-8019.2012.01410.x
PG 4
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 928SQ
UT WOS:000303004600010
PM 22515675
OA gold
DA 2025-06-11
ER

PT J
AU Tarry-Adkins, JL
   Blackmore, HL
   Martin-Gronert, MS
   Fernandez-Twinn, DS
   McConnell, JM
   Hargreaves, IP
   Giussani, DA
   Ozanne, SE
AF Tarry-Adkins, Jane L.
   Blackmore, Heather L.
   Martin-Gronert, Malgorzata S.
   Fernandez-Twinn, Denise S.
   McConnell, Josie M.
   Hargreaves, Iain P.
   Giussani, Dino A.
   Ozanne, Susan E.
TI Coenzyme Q10 prevents accelerated cardiac aging in a rat
   model of poor maternal nutrition and accelerated postnatal growth
SO MOLECULAR METABOLISM
LA English
DT Article
DE Developmental programming; Ubiquinone; Oxidative-stress; DNA damage;
   Telemere length; Cellular senescence
ID OXIDATIVE STRESS; LIFE-SPAN; ANTIOXIDANT PROTECTION;
   MITOCHONDRIAL-FUNCTION; TISSUE CONCENTRATIONS; NITROSATIVE STRESS;
   SAFETY ASSESSMENT; SKELETAL-MUSCLE; STRAND BREAKS; DNA-DAMAGE
AB Studies in human and animals have demonstrated that nutritionally induced low birth-weight followed by rapid postnatal growth increases the risk of metabolic syndrome and cardiovascular disease. Although the mechanisms underlying such nutritional programming are not clearly defined, increased oxidative-stress leading to accelerated cellular aging has been proposed to play an important role. Using an established rodent model of low birth-weight and catch-up growth, we show here that post-weaning dietary supplementation with coenzyme Q(10), a key component of the electron transport chain and a potent antioxidant rescued many of the detrimental effects of nutritional programming on cardiac aging. This included a reduction in nitrosative and oxidative-stress, telomere shortening, DNA damage, cellular senescence and apoptosis. These findings demonstrate the potential for postnatal antioxidant intervention to reverse deleterious phenotypes of developmental programming and therefore provide insight into a potential translatable therapy to prevent cardiovascular disease in at risk humans. (C) 2013 The Authors. Published by Elsevier GmbH. All rights reserved.
C1 [Tarry-Adkins, Jane L.] Univ Cambridge, Metab Res Labs, Cambridge CB2 0QQ, England.
   Addenbrookes Hosp, Addenbrookes Treatment Ctr, MRC Metab Dis Unit, Wellcome Trust MRC Inst Metab Sci, Cambridge CB2 0QQ, England.
   UCL, Natl Hosp, Neurometab Unit, London WC1N 3BG, England.
   Univ Cambridge, Dept Physiol Dev & Neurosci, Cambridge CB2 0QQ, England.
C3 University of Cambridge; Cambridge University Hospitals NHS Foundation
   Trust; Addenbrooke's Hospital; University of Cambridge; University of
   London; University College London; UCL Medical School; University
   College London Hospitals NHS Foundation Trust; National Hospital for
   Neurology & Neurosurgery; University of Cambridge
RP Tarry-Adkins, JL (corresponding author), Univ Cambridge, Metab Res Labs, Cambridge CB2 0QQ, England.
EM janeadkins@googlemail.com
RI Hargreaves, Iain/AAJ-6757-2020; Fernandez-Twinn, Denise/B-3881-2011
OI Tarry-Adkins, Jane/0000-0001-9569-6132; Ozanne,
   Susan/0000-0001-8753-5144; Giussani, Dino/0000-0002-1308-1204;
   Fernandez-Twinn, Denise/0000-0003-2610-277X
FU British Heart Foundation; Medical Research Council; Department of
   Health's NIHR Biomedical Research Centres at UCLH/UCL; BBSRC
   [BB/E002668/1] Funding Source: UKRI; MRC [MC_UU_12012/4] Funding Source:
   UKRI
FX We would like to thank K. Phillips and A. Wayman for their technical
   expertise. This work was supported by The British Heart Foundation and
   the Medical Research Council. SEO is a British Heart Foundation Senior
   Fellow and a member of the MRC Metabolic Diseases Unit. DAG is a Lister
   Institute Fellow and a Royal Society Wolfson Research Merit Award
   Holder. IPH is supported by the Department of Health's NIHR Biomedical
   Research Centres funding scheme at UCLH/UCL.
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NR 77
TC 36
Z9 38
U1 0
U2 11
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2212-8778
J9 MOL METAB
JI Mol. Metab.
PD NOV
PY 2013
VL 2
IS 4
BP 480
EP 490
DI 10.1016/j.molmet.2013.09.004
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA V42UE
UT WOS:000209637900017
PM 24327963
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU van Jaarsveld, CHM
   Fidler, JA
   Steptoe, A
   Boniface, D
   Wardle, J
AF van Jaarsveld, Cornelia H. M.
   Fidler, Jennifer A.
   Steptoe, Andrew
   Boniface, David
   Wardle, Jane
TI Perceived Stress and Weight Gain in Adolescence: A Longitudinal Analysis
SO OBESITY
LA English
DT Article
ID BODY-MASS INDEX; INSULIN-RESISTANCE; METABOLIC SYNDROME; ABDOMINAL
   OBESITY; WAIST CIRCUMFERENCE; DIETARY RESTRAINT; WHITEHALL-II; WORK
   STRESS; FOOD-INTAKE; JOB STRAIN
AB Although perceived stress has been hypothesized to be a risk factor for obesity, epidemiological studies relating stress to weight gain have shown mixed results. We examined prospective associations between perceived stress and changes in waist circumference and BMI in a large study of adolescents. As part of the Health and Behaviour in Teenagers Study (HABITS), height, weight, and waist circumference were measured annually in 4,065 adolescents aged from 11 to 16. Waist and BMI standard deviation scores (SDS) were used as indices of adiposity. Adolescents completed a measure of perceived stress each year, from which mean stress scores over the 5-year period were also calculated and divided by tertile into lower, moderate, and higher stress. Associations between perceived stress at each year and adiposity 1-4 years later and also adiposity trajectories over the whole period in relation to mean stress were investigated. Analyses were adjusted for age, sex, ethnicity, socioeconomic deprivation, pubertal timing, and smoking. Perceived stress in any year was not related prospectively to increases in waist or BMI SDS 1-4 years later, nor was there any evidence that higher stress over the whole period was associated with greater gains in waist or BMI SDS. However, waist and BMI SDS were significantly higher in the moderate-and higher-stress groups than the lower-stress group across the whole 5-year period. Persistent stress was associated with higher waist circumference and BMI in adolescence, but did not lead to differential changes over 5 years.
C1 [van Jaarsveld, Cornelia H. M.; Fidler, Jennifer A.; Boniface, David; Wardle, Jane] UCL, Dept Epidemiol & Publ Hlth, Hlth Behav Res Ctr, London, England.
   [Steptoe, Andrew] UCL, Dept Epidemiol & Publ Hlth, Psychobiol Grp, London, England.
C3 University of London; University College London; University of London;
   University College London
RP Wardle, J (corresponding author), UCL, Dept Epidemiol & Publ Hlth, Hlth Behav Res Ctr, London, England.
EM j.wardle@ucl.ac.uk
RI Fidler, Jennifer/B-5832-2009; Boniface, David/C-1490-2008; Steptoe,
   Andrew/Y-2440-2019; Van Jaarsveld, Cornelia HM/A-4632-2016
OI Steptoe, Andrew/0000-0001-7808-4943; Boniface,
   David/0000-0002-0320-5234; Van Jaarsveld, Cornelia
   HM/0000-0002-4269-0041
FU British Heart Foundation
FX This research was supported by Cancer Research UK. A.S. is supported by
   the British Heart Foundation. We gratefully acknowledge the
   participation of the 36 schools and 5,863 students and the work of all
   those involved in collecting the data.
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NR 41
TC 86
Z9 101
U1 0
U2 20
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1930-7381
EI 1930-739X
J9 OBESITY
JI Obesity
PD DEC
PY 2009
VL 17
IS 12
BP 2155
EP 2161
DI 10.1038/oby.2009.183
PG 7
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 523RD
UT WOS:000272091200006
PM 19521353
OA Bronze
DA 2025-06-11
ER

PT J
AU D'Alonzo, KT
   Johnson, S
   Fanfan, D
AF D'Alonzo, Karen T.
   Johnson, Shanda
   Fanfan, Dany
TI A Biobehavioral Approach to Understanding Obesity and the Development of
   Obesogenic Illnesses Among Latino Immigrants in the United States
SO BIOLOGICAL RESEARCH FOR NURSING
LA English
DT Article
DE allostatic load; obesity; Latinos; acculturation stress
ID ALLOSTATIC LOAD; ACCULTURATIVE STRESS; METABOLIC SYNDROME; MARIANISMO
   BELIEFS; COPING STRATEGIES; PHYSICAL-ACTIVITY; RISK-FACTOR; HEALTH;
   PREVALENCE; OVERWEIGHT
AB The prevalence of obesity and obesity-related illnesses is higher among Hispanics (Latinos) than other racial and ethnic groups, and rates increase exponentially with the number of years living in the United States. Mounting evidence suggests that the origins of many chronic illnesses among disadvantaged minority groups may lie with cumulative exposure to chronic psychological and physiological stressors through the biobehavioral process of allostatic load (AL). Among immigrant Latinos, acculturation stress may contribute to an increase in AL and thus may be an independent risk factor for the development of obesity and obesogenic illnesses. The purpose of this theoretical article is to present a proposed model of the effects of acculturation stress on AL and obesity among Latino immigrants. Such a model can be useful to guide intervention efforts to decrease obesity among immigrant Latinos by adding education, skill building, and social integration strategies to healthy eating and physical activity to reduce the deleterious impact of acculturation stress.
C1 [D'Alonzo, Karen T.; Johnson, Shanda] Rutgers State Univ, Coll Nursing, Newark, NJ 07102 USA.
   [Fanfan, Dany] Florida Int Univ, Miami, FL 33199 USA.
C3 Rutgers University System; Rutgers University New Brunswick; Rutgers
   University Newark; State University System of Florida; Florida
   International University
RP D'Alonzo, KT (corresponding author), Rutgers State Univ, Coll Nursing, Newark, NJ 07102 USA.
EM kdalonzo@rutgers.edu
RI D'Alonzo, Karen/GSM-6563-2022
OI Fanfan, Dany/0000-0003-2802-0364; Johnson, Shanda/0000-0002-9860-6259
FU NINR NIH HHS [K01 NR009381] Funding Source: Medline
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NR 96
TC 26
Z9 38
U1 0
U2 16
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1099-8004
EI 1552-4175
J9 BIOL RES NURS
JI Biol. Res. Nurs.
PD OCT
PY 2012
VL 14
IS 4
SI SI
BP 364
EP 374
DI 10.1177/1099800412457017
PG 11
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA 010XD
UT WOS:000309126900005
PM 22923710
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Siegel, G
   Schmidt, A
   Schäfer, P
   Malmsten, M
   Ringstad, L
   Winkler, K
   Just, S
AF Siegel, Guenter
   Schmidt, Annette
   Schaefer, Petra
   Malmsten, Martin
   Ringstad, Lovisa
   Winkler, Karl
   Just, Soeren
TI The importance of scavenging reactive oxygen species in anti-aging
   medicine
SO ENGINEERING IN LIFE SCIENCES
LA English
DT Article
DE Clinical trial; Ellipsometry; Ginkgo biloba; Metabolic syndrome
ID LOW-DENSITY-LIPOPROTEIN; CORONARY-HEART-DISEASE; GINKGO-BILOBA EXTRACT;
   CARDIOVASCULAR RISK-FACTORS; RECEPTOR-BASED BIOSENSOR; 3RD
   NATIONAL-HEALTH; METABOLIC SYNDROME; ENDOTHELIAL DYSFUNCTION;
   ANTIOXIDANT ACTIVITY; NANOPLAQUE FORMATION
AB In a pilot Study, we had reported on the beneficial effects of Ginkgo biloba (EGb 761) on arteriosclerotic nanoplaque formation and size in cardiovascular high-risk patients who had undergone an aortocoronary bypass operation. Briefly, nanoplaque formation and size, the ratio oxLDL/LDL, and the highly atherothrombotic lipoprotein(a) concentration were substantially reduced, while superoxide dismutase activity and the blood concentration of the vasodilating substances cAMP and cGMP were Upregulated. Since the arteriosclerosis prophylactic and well-aging promotive impact of Ginkgo extract has been proven in this pilot study, we wanted to confirm these beneficial effects through a second observational clinical trial. The measurable variables formerly used were additionally supplemented by a wide, novel biomarker spectrum, through which the latest parameters and markers of plaque stability and progression, oxidative stress, and inflammation were available. In eleven patients with metabolic syndrome in the initial stage, the reduction of arteriosclerotic nanoplaque formation amounted to 14.3 +/- 2.9% (p<0.0077) and of nanoplaque size to 23.4 +/- 3.7% (p<0.0004), respectively, after 2-(SOD) and glutathione peroxidase (GPx) activities were upregulated by 19.6 +/- 10.0% (p<0.0785) and 11.6 +/- 2.3% (p<0.001), respectively, the quotient oxLDL/LDL lowered by 21.0 +/- 4.3% (p<0.002), and lipoprotein(a) concentration decreased by 26.3 +/- 4.8% (p<0.001) in the patients' blood. The concentration of cAMP and cGMP was augmented by 43.5 +/- 12.0% (p<0.001) and 32.9 +/- 10.4% (p<0.001), respectively. Surprisingly, we found a lowering of the serum Ca2+ concentration by 5.4 +/- 1.6% (p<0.0076) from 2.37 +/- 0.03 to 2.24 +/- 0.04 mmol/L (p<0.0069). Apart from an additional vasodilatory effect, the lowered extracellular Ca2+ concentration affects Could show a favourable development of the biomarkers 8-iso-PGF(2 alpha), oxLDL/LDL, SOD, GPx (oxidative stress), hs-CRP, MPO, TNF alpha TGF beta(1) (inflammatory status) and MMP-9 (plaque stability). The markers selected here are suited to provide a comprehensive risk profile for the prevention of arteriosclerosis. Finally, a multiple regression analysis reveals a basis for a mechanistic explanation of nanoplaque reduction under Ginkgo treatment. The arteriosclerosis inhibiting effect is due to an attenuation of the risk factors oxLDL/LDL, Lp(a), and [Ca2+](o) as well as to a significant increase in the vasodilator cAMP and cGMP concentration. Thus, Ginkgo with its pleiotropic effects should be assigned a fixed rank among the anti-aging medical therapeutics as a prophylactic measure, especially in patients with early-stage metabolic syndrome.
C1 [Siegel, Guenter; Schaefer, Petra; Malmsten, Martin] Charite, Inst Physiol, D-14195 Berlin, Germany.
   [Schmidt, Annette] Univ Munster, Leibniz Inst Arteriosclerosis Res, D-48149 Munster, Germany.
   [Siegel, Guenter; Malmsten, Martin; Ringstad, Lovisa] Uppsala Univ, Dept Phys Chem, Inst Pharm, S-75123 Uppsala, Sweden.
   [Winkler, Karl] Univ Clin Freiburg, Inst Clin Chem, D-79106 Freiburg, Germany.
   [Just, Soeren] Heart Ctr Cottbus, Dept Cardiac Surg, D-03048 Cottbus, Germany.
C3 Berlin Institute of Health; Free University of Berlin; Humboldt
   University of Berlin; Charite Universitatsmedizin Berlin; University of
   Munster; Uppsala University; University of Freiburg
RP Siegel, G (corresponding author), Charite, Inst Physiol, Campus Benjamin Franklin,Arnimallee 22, D-14195 Berlin, Germany.
EM guenter.siegel@charite.de
FU Spitzner Arzneimittel, Germany
FX G. Siegal was partially supporetd by a research grant from Spitzner
   Arzneimittel, Germany.
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NR 84
TC 8
Z9 9
U1 0
U2 13
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1618-0240
EI 1618-2863
J9 ENG LIFE SCI
JI Eng. Life Sci.
PD OCT
PY 2009
VL 9
IS 5
SI SI
BP 363
EP 375
DI 10.1002/elsc.200800112
PG 13
WC Biotechnology & Applied Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology
GA 525IE
UT WOS:000272207800002
DA 2025-06-11
ER

PT J
AU Sahar, S
   Sassone-Corsi, P
AF Sahar, Saurabh
   Sassone-Corsi, Paolo
TI Regulation of metabolism: the circadian clock dictates the time
SO TRENDS IN ENDOCRINOLOGY AND METABOLISM
LA English
DT Review
ID REV-ERB-ALPHA; ARNT-LIKE PROTEIN-1; RECIPROCAL REGULATION;
   GLUCOSE-HOMEOSTASIS; HEME-BIOSYNTHESIS; NUCLEAR RECEPTORS; MAMMALIAN
   CLOCK; MOLECULAR CLOCK; SHIFT WORK; TRANSCRIPTION
AB Circadian rhythms occur with a periodicity of approximately 24 h and regulate a wide array of metabolic and physiologic functions. Accumulating epidemiological and genetic evidence indicates that disruption of circadian rhythms can be directly linked to many pathological conditions, including sleep disorders, depression, metabolic syndrome and cancer. Intriguingly, several molecular gears constituting the clock machinery have been found to establish functional interplays with regulators of cellular metabolism. Although the circadian clock regulates multiple metabolic pathways, metabolite availability and feeding behavior can in turn regulate the circadian clock. An in-depth understanding of this reciprocal regulation of circadian rhythms and cellular metabolism may provide insights into the development of therapeutic intervention against specific metabolic disorders.
C1 [Sahar, Saurabh; Sassone-Corsi, Paolo] Univ Calif Irvine, Sch Med, Ctr Epigenet & Metab, Irvine, CA 92697 USA.
C3 University of California System; University of California Irvine
RP Sassone-Corsi, P (corresponding author), Univ Calif Irvine, Sch Med, Ctr Epigenet & Metab, Irvine, CA 92697 USA.
EM psc@uci.edu
FU National Institutes of Health; Institut de la Sante et de la Recherche
   Medicale (France); Sirtris Pharmaceutical Inc.
FX We wish to apologize to all colleagues whose work, because of lack of
   space, could not be cited. We thank all the members of the Sassone-Corsi
   laboratory for helpful discussions. Work in our laboratory is supported
   by the National Institutes of Health, the Institut de la Sante et de la
   Recherche Medicale (France), and Sirtris Pharmaceutical Inc.
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NR 84
TC 159
Z9 181
U1 3
U2 49
PU ELSEVIER SCIENCE LONDON
PI LONDON
PA 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND
SN 1043-2760
EI 1879-3061
J9 TRENDS ENDOCRIN MET
JI Trends Endocrinol. Metab.
PD JAN
PY 2012
VL 23
IS 1
BP 1
EP 8
DI 10.1016/j.tem.2011.10.005
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 881AE
UT WOS:000299450900001
PM 22169754
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Ciesielska, K
   Gajewska, M
AF Ciesielska, Karolina
   Gajewska, Malgorzata
TI Fatty Acids as Potent Modulators of Autophagy Activity in White Adipose
   Tissue
SO BIOMOLECULES
LA English
DT Review
DE autophagy; obesity; WAT; fatty acids; ER stress
ID CONJUGATED LINOLEIC-ACID; ENDOPLASMIC-RETICULUM STRESS; QUALITY-CONTROL;
   DIETARY-FAT; ER STRESS; INSULIN-RESISTANCE; BODY-COMPOSITION; OBESITY;
   INFLAMMATION; DEGRADATION
AB A high-fat diet is one of the causative factors of obesity. The dietary profile of fatty acids is also an important variable in developing obesity, as saturated fatty acids are more obesogenic than monounsaturated and polyunsaturated fatty acids. Overweight and obesity are inseparably connected with the excess of adipose tissue in the body, characterized by hypertrophy and hyperplasia of fat cells, which increases the risk of developing metabolic syndrome. Changes observed within hypertrophic adipocytes result in elevated oxidative stress, unfolded protein accumulation, and increased endoplasmic reticulum (ER) stress. One of the processes involved in preservation of cellular homeostasis is autophagy, which is defined as an intracellular lysosome-dependent degradation system that serves to recycle available macromolecules and eliminate damaged organelles. In obesity, activation of autophagy is increased and the process appears to be regulated by different types of dietary fatty acids. This review describes the role of autophagy in adipose tissue and summarizes the current understanding of the effects of saturated and unsaturated fatty acids in autophagy modulation in adipocytes.
C1 [Ciesielska, Karolina; Gajewska, Malgorzata] Warsaw Univ Life Sci WULS, Inst Vet Med, Dept Physiol Sci, SGGW, Nowoursynowska 159b, PL-02776 Warsaw, Poland.
C3 Warsaw University of Life Sciences
RP Ciesielska, K (corresponding author), Warsaw Univ Life Sci WULS, Inst Vet Med, Dept Physiol Sci, SGGW, Nowoursynowska 159b, PL-02776 Warsaw, Poland.
EM karolina_ciesielska@sggw.edu.pl
FU National Science Centre Poland [2018/31/B/NZ9/00658,
   UMO-2018/31/B/NZ9/00658]
FX This review paper was funded by National Science Centre Poland, grant
   number: 2018/31/B/NZ9/00658 (UMO-2018/31/B/NZ9/00658).
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NR 132
TC 18
Z9 18
U1 2
U2 10
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2218-273X
J9 BIOMOLECULES
JI Biomolecules
PD FEB
PY 2023
VL 13
IS 2
AR 255
DI 10.3390/biom13020255
PG 20
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 9G7CI
UT WOS:000938306100001
PM 36830623
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Paschou, SA
   Kosmopoulos, M
   Nikas, IP
   Spartalis, M
   Kassi, E
   Goulis, DG
   Lambrinoudaki, I
   Siasos, G
AF Paschou, Stavroula A.
   Kosmopoulos, Marinos
   Nikas, Ilias P.
   Spartalis, Michael
   Kassi, Evanthia
   Goulis, Dimitrios G.
   Lambrinoudaki, Irene
   Siasos, Gerasimos
TI The Impact of Obesity on the Association between Vitamin D Deficiency
   and Cardiovascular Disease
SO NUTRIENTS
LA English
DT Article
DE vitamin D; obesity; cardiovascular disease; atherosclerosis
ID BODY-MASS INDEX; OXIDATIVE STRESS; RISK-FACTORS; CARDIOMETABOLIC RISK;
   25-HYDROXYVITAMIN D; HYPOVITAMINOSIS-D; D SUPPLEMENTATION; CALCIUM;
   MORTALITY; FAT
AB The aim of this article is to review the literature regarding the relationship between vitamin D deficiency and cardiovascular disease (CVD) and its modification in the presence of obesity. Despite the strong association between vitamin D status and cardiovascular outcomes, vitamin D supplementation trials in the general population have failed to decrease the incidence of cardiovascular events and mortality. A comprehensive study of the published literature and a comparison with experimental data lead to the conclusion that obesity, due to its high prevalence and strong association with both vitamin D deficiency and CVD, may act as a critical confounder, which is responsible for the different results on this association. Adoption of a vitamin D preventive supplementation strategy for CVD is unlikely to yield any benefit to the general population. However, it might be particularly useful in obese adults with increased risk for CVD.
C1 [Paschou, Stavroula A.] Natl & Kapodistrian Univ Athens, Aghia Sophia Hosp, Med Sch, Div Endocrinol & Diabet, Athens 11527, Greece.
   [Paschou, Stavroula A.; Nikas, Ilias P.] European Univ Cyprus, Sch Med, CY-2404 Nicosia, Cyprus.
   [Kosmopoulos, Marinos] Univ Minnesota, Sch Med, Dept Med, Div Cardiol, Minneapolis, MN 55455 USA.
   [Spartalis, Michael] Onassis Cardiac Surg Ctr, Div Cardiol, Athens 17674, Greece.
   [Kassi, Evanthia] Natl & Kapodistrian Univ Athens, Dept Biol Chem, Med Sch, Athens 11527, Greece.
   [Goulis, Dimitrios G.] Aristotle Univ Thessaloniki, Med Sch, Dept Obstet & Gynecol, Unit Reprod Endocrinol, Thessaloniki 56403, Greece.
   [Lambrinoudaki, Irene] Natl & Kapodistrian Univ Athens, Med Sch, Dept Obstet & Gynecol, Athens 11526, Greece.
   [Siasos, Gerasimos] Natl & Kapodistrian Univ Athens, Hippokrat Hosp, Med Sch, Dept Cardiol, Athens 11526, Greece.
C3 National & Kapodistrian University of Athens; European University
   Cyprus; University of Minnesota System; University of Minnesota Twin
   Cities; Onassis Cardiac Surgery Center; National & Kapodistrian
   University of Athens; Aristotle University of Thessaloniki; National &
   Kapodistrian University of Athens; National & Kapodistrian University of
   Athens; Hippokration General Hospital
RP Paschou, SA (corresponding author), Natl & Kapodistrian Univ Athens, Aghia Sophia Hosp, Med Sch, Div Endocrinol & Diabet, Athens 11527, Greece.; Paschou, SA (corresponding author), European Univ Cyprus, Sch Med, CY-2404 Nicosia, Cyprus.
EM s.a.paschou@gmail.com; marinos.kosmopoulos@outlook.com.gr;
   i.nikas@euc.ac.cy; msparta@med.uoa.gr; evakassis@gmail.com;
   dimitrios.goulis@gmail.com; ilambrinoudaki@med.uoa.gr;
   gsiasos@med.uoa.gr
RI Goulis, Dimitrios/AAG-4589-2020; Siasos, Gerasimos/AAD-7218-2019;
   Spartalis, Michael/I-1713-2019
OI Siasos, Gerasimos/0000-0001-7601-8870; Nikas, Ilias/0000-0001-8625-2556;
   Spartalis, Michael/0000-0002-7442-838X; Paschou,
   Stavroula/0000-0002-0651-1376; Lambrinoudaki, Irene/0000-0003-1488-2668
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NR 80
TC 24
Z9 26
U1 1
U2 6
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD OCT
PY 2019
VL 11
IS 10
AR 2458
DI 10.3390/nu11102458
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA JP4HG
UT WOS:000498227300199
PM 31615154
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Ross, K
   Martin, T
   Chen, E
   Miller, GE
AF Ross, Kharah
   Martin, Tara
   Chen, Edith
   Miller, Gregory E.
TI Social encounters in daily life and 2-year changes in metabolic risk
   factors in young women
SO DEVELOPMENT AND PSYCHOPATHOLOGY
LA English
DT Article
ID CORONARY-HEART-DISEASE; AMBULATORY BLOOD-PRESSURE; PHYSICAL-ACTIVITY;
   CARDIOVASCULAR REACTIVITY; MARITAL CONFLICT; ARTERY-DISEASE;
   MYOCARDIAL-INFARCTION; MENTAL STRESS; CARDIORESPIRATORY FITNESS;
   PSYCHOLOGICAL DISTRESS
AB Research shows that poor social ties increase risks of morbidity and mortality from cardiovascular disease (CVD). However, little is known about the nature of everyday social encounters that give rise to this association, or when in the course of development they begin to shape disease-relevant biological processes. In this study, 122 adolescent females recorded the qualities of their everyday social interactions using electronic diaries. At the same time we measured components of the metabolic syndrome, a precursor to CVD that includes central adiposity, high blood pressure, insulin resistance, and lipid dysregulation. Metabolic symptoms were reassessed 12 and 24 months later. Hierarchical linear modeling revealed an association between negative social interactions and metabolic symptom trajectories. To the extent that participants had more intense negative social encounters in daily life, they showed increasing scores on a composite indicator of metabolic risk over 2 years. This association was independent of a variety of potential confounders, and persisted when symptoms of depression and broader personality traits were controlled. There was no association between positive social encounters and metabolic risk trajectories. These findings suggest that even in otherwise healthy adolescents, abrasive social encounters may accelerate the progression of early stages of CVD.
C1 [Ross, Kharah] Univ British Columbia, Dept Psychol, Vancouver, BC V6T 1Z4, Canada.
C3 University of British Columbia
RP Ross, K (corresponding author), Univ British Columbia, Dept Psychol, 2136 West Mall, Vancouver, BC V6T 1Z4, Canada.
EM kmross@psych.ubc.ca
RI ; Ross, Kharah/M-1453-2016
OI Miller, Gregory/0000-0002-7217-1082; Ross, Kharah/0000-0002-1472-5630
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NR 84
TC 24
Z9 32
U1 0
U2 11
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
SN 0954-5794
EI 1469-2198
J9 DEV PSYCHOPATHOL
JI Dev. Psychopathol.
PD AUG
PY 2011
VL 23
IS 3
SI SI
BP 897
EP 906
DI 10.1017/S0954579411000381
PG 10
WC Psychology, Developmental
WE Social Science Citation Index (SSCI)
SC Psychology
GA 801OY
UT WOS:000293451100012
PM 21756440
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Waldman, ZC
   Schenk, BR
   Karera, MGD
   Patterson, AC
   Hormenu, T
   Mabundo, LS
   DuBose, CW
   Jagannathan, R
   Whitesell, PL
   Wentzel, A
   Horlyck-Romanovsky, MF
   Sumner, AE
AF Waldman, Zoe C.
   Schenk, Blayne R.
   Duhuze Karera, Marie Grace
   Patterson, Arielle C.
   Hormenu, Thomas
   Mabundo, Lilian S.
   DuBose, Christopher W.
   Jagannathan, Ram
   Whitesell, Peter L.
   Wentzel, Annemarie
   Horlyck-Romanovsky, Margrethe F.
   Sumner, Anne E.
TI Sleep and Economic Status Are Linked to Daily Life Stress in
   African-Born Blacks Living in America
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Article
DE African immigrants; perceived stress; sleep quality; socioeconomic
   status
ID CARDIOMETABOLIC HEALTH; CARDIOVASCULAR HEALTH; METABOLIC SYNDROME;
   GLUCOSE-TOLERANCE; RISK-FACTORS; IMMIGRANTS; DURATION; QUALITY;
   ASSOCIATION; HEMOGLOBIN
AB To identify determinants of daily life stress in Africans in America, 156 African-born Blacks (Age: 40 +/- 10 years (mean +/- SD), range 22-65 years) who came to the United States as adults (age >= 18 years) were asked about stress, sleep, behavior and socioeconomic status. Daily life stress and sleep quality were assessed with the Perceived Stress Scale (PSS) and Pittsburgh Sleep Quality Index (PSQI), respectively. High-stress was defined by the threshold of the upper quartile of population distribution of PSS (>= 16) and low-stress as PSS < 16. Poor sleep quality required PSQI > 5. Low income was defined as <40 k yearly. In the high and low-stress groups, PSS were: 21 +/- 4 versus 9 +/- 4, p < 0.001 and PSQI were: 6 +/- 3 versus 4 +/- 3, p < 0.001, respectively. PSS and PSQI were correlated (r = 0.38, p < 0.001). The odds of high-stress were higher among those with poor sleep quality (OR 5.11, 95% CI: 2.07, 12.62), low income (OR 5.03, 95% CI: 1.75, 14.47), and no health insurance (OR 3.01, 95% CI: 1.19, 8.56). Overall, in African-born Blacks living in America, daily life stress appears to be linked to poor quality sleep and exacerbated by low income and lack of health insurance.
C1 [Waldman, Zoe C.; Schenk, Blayne R.; Duhuze Karera, Marie Grace; Patterson, Arielle C.; Hormenu, Thomas; Mabundo, Lilian S.; DuBose, Christopher W.; Wentzel, Annemarie; Horlyck-Romanovsky, Margrethe F.; Sumner, Anne E.] NIDDKD, Sect Ethn & Hlth, Diabet Endocrinol & Obes Branch, Bethesda, MD USA.
   [Duhuze Karera, Marie Grace; Sumner, Anne E.] Natl Inst Minor Hlth & Hlth Dispar, Bethesda, MD USA.
   [Duhuze Karera, Marie Grace] Univ Global Hlth Equ, Inst Global Hlth Equ Res, Kigali, Rwanda.
   [Hormenu, Thomas] Univ Cape Coast, Dept Hlth, Phys Educ, POB 5007, Cape Coast, Ghana.
   [Jagannathan, Ram] Emory Univ, Sch Med, Dept Med, Atlanta, GA USA.
   [Whitesell, Peter L.] Howard Univ, Howard Univ Hosp, Sleep Disorders Ctr, 2041 Georgia Ave NW, Washington, DC USA.
   [Horlyck-Romanovsky, Margrethe F.] City Univ New York, Brooklyn Coll, Dept Hlth & Nutr Sci, New York, NY USA.
C3 National Institutes of Health (NIH) - USA; NIH National Institute of
   Diabetes & Digestive & Kidney Diseases (NIDDK); National Institutes of
   Health (NIH) - USA; NIH National Institute on Minority Health & Health
   Disparities (NIMHD); University of Cape Coast; Emory University; Howard
   University; City University of New York (CUNY) System; Brooklyn College
   (CUNY)
RP Sumner, AE (corresponding author), NIDDKD, Sect Ethn & Hlth, Diabet Endocrinol & Obes Branch, Bethesda, MD USA.; Sumner, AE (corresponding author), Natl Inst Minor Hlth & Hlth Dispar, Bethesda, MD USA.
EM blayne.schenk@nih.gov; gduhuze@ughe.org; arielle.patterson@nih.gov;
   thormenu@ucc.edu.gh; lilian.mabundo@nih.gov; christopher.dubose@nih.gov;
   thormenu@ucc.edu.gh; ram.jagannathan@emory.edu;
   peter.whitesell@howard.edu; annemarie.wentzel@nih.gov;
   margrethehr@brooklyn.cuny.edu; zoe.waldman@nih.gov
RI Hormenu, Thomas/JBJ-0389-2023; Jagannathan, Ram/J-1149-2019; Wentzel,
   Annemarie/IUO-0720-2023; Horlyck-Romanovsky, Margrethe/AAZ-4740-2020
OI Whitesell, Peter/0000-0002-3654-6203; Schenk,
   Blayne/0000-0002-9990-424X; Waldman, Zoe/0000-0002-7016-4065; Hormenu,
   Thomas/0000-0002-9416-4406; Sumner, Anne/0000-0001-9640-8999; Duhuze
   Karera, Grace/0000-0002-0815-3576
FU NIDDK; NIMHD
FX Funding came from the Intramural Programs of NIDDK and NIMHD.
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NR 54
TC 4
Z9 4
U1 0
U2 5
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD MAR
PY 2022
VL 19
IS 5
AR 2562
DI 10.3390/ijerph19052562
PG 14
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA ZY8MD
UT WOS:000772834100001
PM 35270258
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Akki, R
   Raghay, K
   Errami, M
AF Akki, Rachid
   Raghay, Kawtar
   Errami, Mohammed
TI Potentiality of ghrelin as antioxidant and protective agent
SO REDOX REPORT
LA English
DT Review
DE Ghrelin; antioxidant; oxidative stress; systemic oxidative stress sensor
ID INDUCED OXIDATIVE STRESS; STEM-CELL FACTOR; ACUTE-PANCREATITIS;
   METABOLIC SYNDROME; ACYLATED GHRELIN; PLASMA GHRELIN; LIVER-INJURY;
   APOPTOSIS; OBESITY; SYSTEM
AB Background
   Oxidative stress is the result of cellular troubles related to aerobic metabolism. Furthermore, this stress is always associated with biological responses evoked by physical, chemical, environmental, and psychological factors. Several studies have developed many approaches of antioxidant defense to diminish the severity of many diseases. Ghrelin was originally identified from the rat stomach, and it is a potent growth hormone-releasing peptide that has pleiotropic functions.
   Methods
   A systematic review was conducted within PubMed, ScienceDirect, MEDLINE, and Scopus databases using keywords such as ghrelin, antioxidant, oxidative stress, and systemic oxidative stress sensor.
   Results
   In the last decade, many studies show that ghrelin exhibits protection effects against oxidative stress derived probably from its antioxidant effects. Pieces of evidence demonstrate that systemic oxidative stress increase ghrelin levels in the plasma. The expression of ghrelin and its receptor in ghrelin peripheral tissues and extensively in the central nervous system suggests that this endogenous peptide plays an important role as a systemic oxidative stress sensor
   Conclusion
   The current evidence confirms that ghrelin and its derived peptides (Desacyl-ghrelin, obestatin) act as a protective antioxidant agent. Therefore, stressor modality, duration, and intensity are the parameters of oxidative stress that must be taken into consideration to determine the role of ghrelin, Desacyl-ghrelin, and obestatin in the regulation of cell death pathways.
C1 [Akki, Rachid] Natl Sch Agr Meknes ENA, Dept Plant Protect & Environm, Meknes, Morocco.
   [Akki, Rachid; Raghay, Kawtar; Errami, Mohammed] Abdelmalek Essaadi Univ, Fac Sci, Dept Biol, Tetouan, Morocco.
C3 Moulay Ismail University of Meknes; Abdelmalek Essaadi University of
   Tetouan
RP Akki, R (corresponding author), Natl Sch Agr Meknes ENA, Dept Plant Protect & Environm, Meknes, Morocco.; Akki, R (corresponding author), Abdelmalek Essaadi Univ, Fac Sci, Dept Biol, Tetouan, Morocco.
EM akki.rachid2011@gmail.com
RI ; Raghay, Kawtar/AAO-9015-2020
OI AKKI, RACHID/0000-0001-7653-5480; Raghay, Kawtar/0000-0003-2695-2635
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NR 105
TC 16
Z9 16
U1 2
U2 14
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1351-0002
EI 1743-2928
J9 REDOX REP
JI Redox Rep.
PD JAN 1
PY 2021
VL 26
IS 1
BP 71
EP 79
DI 10.1080/13510002.2021.1913374
PG 9
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA RN0BU
UT WOS:000640021800001
PM 33849404
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Burgess, APH
   Vanella, L
   Bellner, L
   Gotlinger, K
   Falck, JR
   Abraham, NG
   Schwartzman, ML
   Kappas, A
AF Burgess, Angela P. H.
   Vanella, Luca
   Bellner, Lars
   Gotlinger, Katherine
   Falck, John R.
   Abraham, Nader G.
   Schwartzman, Michal L.
   Kappas, Attallah
TI Heme Oxygenase (HO-1) Rescue of Adipocyte Dysfunction in HO-2 Deficient
   Mice via Recruitment of Epoxyeicosatrienoic Acids (EETs) and Adiponectin
SO CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
LA English
DT Article
DE HO; Stress response genes; Antioxidants; Cardiovascular; Diabetes;
   Carbon monoxide; Bilirubin
ID NECROSIS-FACTOR-ALPHA; OXIDATIVE STRESS; EPOXIDE HYDROLASE;
   11,12-EPOXYEICOSATRIENOIC ACID; INSULIN SENSITIVITY; THERAPEUTIC
   TARGETS; EXPRESSION; EPOXYGENASE; INDUCTION; INCREASES
AB Background/Aims: HO-1 and EETs are functionally linked and their interactions influence body weight, insulin sensitivity, and serum levels of inflammatory cytokines in metabolic syndrome phenotype of HO-2 null mice. The HO-2 isozyme is essential for regulating physiological levels of ROS. Recent studies have suggested a potential role of EET in modifying adipocyte differentiation through up-regulation of HO-1-adiponectin-AkT signaling in human mesenchymal stem cells (MSCs). Our aim was to examine the consequences of HO deficiency on MSC-derived adipogenesis in vitro using MSC derived from HO-2 null and WT mice in vivo. Methods: Four-month-old HO-2 null (HO-2(-/-)) and B6/129SF2/J (WT) mice were divided into three groups (four mice/group): WT, HO2(-/-), and HO-2(-/-) + CoPP. Adipogenesis was performed on purified MSC-derived adipocytes cultured in adipogenic differentiation media and an EET-agonist was added every 3 days. Results: HO-2 depletion of MSC adipocytes resulted in increased adipogenesis (p<0.01) and increased levels of inflammatory cytokines including (TNF)-alpha (p<0.05), (MCP)-1 (p<0.05), and (IL-1)-beta (p<0.05). These results were accompanied by decreases in HO-1 (p<0.05) and subsequently EET and HO activity (p<0.05). Upregulation of HO-1 resulted in decreased MSC-derived adipocyte differentiation, decreased production of TNF-alpha and MCP-1 and increased levels of adiponectin (p<0.05). Cyp2J5 (p<0.05), HO-1 (p<0.05), and adiponectin mRNA levels (p<0.05) were also decreased in visceral adipose tissue isolated from HO-2 null compared to WT mice. EET agonist stimulation of MSC adipocytes derived from HO-2 null mice yielded similar results. Conclusion: Increased levels of EET and HO-1 are essential for protection against the adverse effects of adipocyte hypertrophy and the ensuing metabolic syndrome. These results offer a portal into therapeutic approaches for the prevention of the metabolic syndrome. Copyright (C) 2012 S. Karger AG, Basel
C1 [Kappas, Attallah] Rockefeller Univ Hosp, New York, NY 10021 USA.
   [Burgess, Angela P. H.; Vanella, Luca; Abraham, Nader G.] Univ Toledo, Dept Physiol & Pharmacol, Toledo, OH 43606 USA.
   [Bellner, Lars; Gotlinger, Katherine; Schwartzman, Michal L.] New York Med Coll, Dept Pharmacol, Valhalla, NY 10595 USA.
   [Falck, John R.] Univ Texas SW Med Ctr Dallas, Dept Biochem, Dallas, TX 75390 USA.
C3 Rockefeller University; University System of Ohio; University of Toledo;
   New York Medical College; University of Texas System; University of
   Texas Southwestern Medical Center Dallas
RP Kappas, A (corresponding author), Rockefeller Univ Hosp, 1230 York Ave, New York, NY 10021 USA.
EM michal_schwartzman@nymc.edu; kappas@rockefeller.edu
RI Falck, John/B-3030-2011; Vanella, Luca/J-7354-2016
OI Falck, John/0000-0002-9219-7845; Vanella, Luca/0000-0002-6314-6029
FU NIH [DK068134, HL55601, HL34300]; Beatrice Renfield Foundation
FX This work was supported by NIH grants DK068134, HL55601 (NGA), HL34300
   (MLS), and The Beatrice Renfield Foundation (AK).
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NR 45
TC 39
Z9 41
U1 0
U2 3
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1015-8987
EI 1421-9778
J9 CELL PHYSIOL BIOCHEM
JI Cell. Physiol. Biochem.
PY 2012
VL 29
IS 1-2
BP 99
EP 110
DI 10.1159/000337591
PG 12
WC Cell Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Physiology
GA 903SQ
UT WOS:000301141400011
PM 22415079
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Hung, WC
   Ling, XH
   Chang, CC
   Hsu, HF
   Wang, SW
   Lee, YC
   Luo, C
   Lee, YT
   Houng, JY
AF Hung, Wei-Chin
   Ling, Xue-Hua
   Chang, Chi-Chang
   Hsu, Hsia-Fen
   Wang, Shih-Wei
   Lee, Yi-Chen
   Luo, Ci
   Lee, Yun-Tzu
   Houng, Jer-Yiing
TI Inhibitory Effects of Siegesbeckia orientalis Extracts on
   Advanced Glycation End Product Formation and Key Enzymes Related to
   Metabolic Syndrome
SO MOLECULES
LA English
DT Article
DE Siegesbeckia orientalis linne; antioxidation; advanced glycation end
   products; alpha-amylase; alpha-glucosidase; lipase; angiotensin
   I-converting enzyme
ID ANGIOTENSIN-CONVERTING ENZYME; ALPHA-GLUCOSIDASE; PHENOLIC-COMPOUNDS;
   ANTIOXIDANT ACTIVITY; DIETARY POLYPHENOLS; OXIDATIVE STRESS; ETHANOL
   EXTRACT; AMYLASE; OBESITY; COMPLICATIONS
AB Metabolic syndrome typically includes Type 2 diabetes associated with hyperglycemia, central obesity, dyslipidemia and hypertension. It is highly related to oxidative stress, formation of advanced glycated end products (AGEs) and key enzymes, such as carbohydrate digesting enzymes like pancreatic alpha-amylase and intestinal alpha-glucosidase, pancreatic lipase and angiotensin I-converting enzyme (ACE). This study used an in vitro approach to assess the potential of four extracts of Siegesbeckia orientalis linne on key enzymes relevant to metabolic syndrome. In this research, S. orientailis was firstly extracted by ethanol. The ethanol extract (SE) was then partitioned sequentially with hexane, ethyl acetate and methanol, and these extracts were named SE-Hex, SE-EA and SE-MeOH, respectively. The experimental results showed that SE-EA had the highest total phenolic content (TPC, 76.9 +/- 1.8 mg/g) and the total flavonoids content (TFC, 5.3 +/- 0.3 mg/g). This extract exhibited the most significant antioxidant activities, including DPPH radical-scavenging capacity (IC50 = 161.8 +/- 2.4 mu g/mL), ABTS radical-scavenging capacity (IC50 = 13.9 +/- 1.5 mu g/mL) and reducing power. For anti-glycation activities, SE-EA showed the best results in the inhibition of AGEs, as well as inhibitory activities against alpha-glucosidase (IC50 = 362.3 +/- 9.2 mu g/mL) and alpha-amylase (IC50 = 119.0 +/- 17.7 mu g/mL). For anti-obesity activities, SE-EA indicated the highest suppression effect on pancreatic lipase (IC50 = 3.67 +/- 0.52 mg/mL). Finally, for anti-hypertension activity, SE-EA also demonstrated the strongest inhibitory activity on ACE (IC50 = 626.6 +/- 15.0 mu g/mL). Close relationships were observed among the parameters of TPC, antioxidant activities, inhibitory activities on alpha-amylase, alpha-glucosidase, lipase and ACE (R > 0.9). Moderate correlations were found among the parameters of TFC, antioxidant activities, and suppression of dicarbonyl compounds formation (R = 0.5-0.9). Taken together these in vitro studies reveal the therapeutic potential of SE-EA extract in the prevention and treatment of metabolic disorders.
C1 [Hung, Wei-Chin] E Da Hosp, Div Cardiol, Kaohsiung 82445, Taiwan.
   [Ling, Xue-Hua; Houng, Jer-Yiing] I Shou Univ, Grad Inst Biotechnol & Chem Engn, Kaohsiung 84001, Taiwan.
   [Ling, Xue-Hua; Chang, Chi-Chang] I Shou Univ, E Da Hosp, Dept Obstet & Gynecol, Kaohsiung 82445, Taiwan.
   [Hsu, Hsia-Fen; Luo, Ci; Lee, Yun-Tzu; Houng, Jer-Yiing] I Shou Univ, Dept Nutr, Kaohsiung 82445, Taiwan.
   [Wang, Shih-Wei] I Shou Univ, E Da Hosp, Dept Internal Med, Div Allergy Immunol & Rheumatol, Kaohsiung 82445, Taiwan.
   [Lee, Yi-Chen] E Da Hosp, Dept Nutr Therapy, Kaohsiung 82445, Taiwan.
C3 E-Da Hospital; I Shou University; E-Da Hospital; I Shou University; I
   Shou University; I Shou University; E-Da Hospital; E-Da Hospital
RP Houng, JY (corresponding author), I Shou Univ, Grad Inst Biotechnol & Chem Engn, Kaohsiung 84001, Taiwan.; Houng, JY (corresponding author), I Shou Univ, Dept Nutr, Kaohsiung 82445, Taiwan.
EM ed102600@edah.org.tw; ed107312@gmail.com; ed101779@edah.org.tw;
   fen153848@gmail.com; shihwei8888@gmail.com; ed103549@edah.org.tw;
   r9620239@yahoo.com.tw; lisa10143018@gmail.com; jyhoung@isu.edu.tw
RI Houng, Jer-yiing/W-2464-2019
OI Houng, Jer-Yiing/0000-0002-9723-9987
FU E-Da Hospital, Taiwan [EDAHP106027]; I-Shou University [ISU-104-IUC-01];
   Ministry of Science and Technology of Taiwan [MOST102-2221-E-214-037]
FX The authors gratefully acknowledge the financial support of E-Da
   Hospital, Taiwan (EDAHP106027), I-Shou University (ISU-104-IUC-01), and
   the Ministry of Science and Technology of Taiwan
   (MOST102-2221-E-214-037).
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NR 73
TC 16
Z9 16
U1 0
U2 2
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1420-3049
J9 MOLECULES
JI Molecules
PD OCT
PY 2017
VL 22
IS 10
AR 1785
DI 10.3390/molecules22101785
PG 18
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA FM0PZ
UT WOS:000414670600205
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Andersson, G
   Ljótsson, B
   Weise, C
AF Andersson, Gerhard
   Ljotsson, Brjann
   Weise, Cornelia
TI Internet-delivered treatment to promote health
SO CURRENT OPINION IN PSYCHIATRY
LA English
DT Article
DE children and adolescents; Internet interventions; peer support
ID COGNITIVE-BEHAVIOR THERAPY; SELF-MANAGEMENT PROGRAM; PHYSICAL-ACTIVITY;
   WEIGHT-LOSS; SUPPORT; WOMEN; ADOLESCENTS; INTERVENTION; DEPRESSION;
   ARTHRITIS
AB Purpose of review
   The aim of this paper is to provide an updated review of recent controlled trials of Internet interventions for health conditions and how the Internet is used to promote health.
   Recent findings
   We identified 18 published trials including studies on diabetes, cancer, pain conditions, obesity, irritable bowel syndrome, stress management, hypertension, metabolic syndrome, cerebral palsy, infertility, HIV infection, and fruit/vegetable consumption. Of the 18 trials, one-third targeted children and adolescents. Two cancer studies investigated the role of peer support in an online environment that failed to result in any major improvements. Overall, several trials did not result in any substantial significant improvements, but there are exceptions, such as treatment of irritable bowel syndrome, headache, and chronic pain. Although a few of the reviewed studies had sufficient sample sizes, the majority were small and underpowered. In particular, this was the case for the studies on children and adolescents.
   Summary
   This review suggests that Internet interventions hold some promise as a complement to other treatments such as cognitive behavior therapy. The benefits from participating in online peer support groups are not clear. Although studies on children and adolescents have emerged, there is a lack of studies on older adults with health problems.
C1 [Andersson, Gerhard; Weise, Cornelia] Linkoping Univ, Dept Behav Sci & Learning, Swedish Inst Disabil Res, SE-58183 Linkoping, Sweden.
   [Andersson, Gerhard; Ljotsson, Brjann] Karolinska Inst, Psychiat Sect, Dept Clin Neurosci, Stockholm, Sweden.
C3 Linkoping University; Karolinska Institutet
RP Andersson, G (corresponding author), Linkoping Univ, Dept Behav Sci & Learning, Swedish Inst Disabil Res, SE-58183 Linkoping, Sweden.
EM Gerhard.Andersson@liu.se
RI Weise, Cornelia/G-6825-2013; Andersson, Gerhard/J-8529-2012
OI Weise, Cornelia/0000-0001-5216-1031; Andersson,
   Gerhard/0000-0003-4753-6745; Ljotsson, Brjann/0000-0001-8086-1668
FU Linneus centre head in Linkoping, Sweden; Swedish Research Council;
   Swedish council for working and life research; European Community
FX The authors have no conflict of interest. G. A. and C. W. are sponsored
   in part by a grant for the Linneus centre head in Linkoping, Sweden. G.
   A. has funding from the Swedish Research Council, the Swedish council
   for working and life research and the European Community.
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NR 34
TC 32
Z9 40
U1 0
U2 44
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0951-7367
EI 1473-6578
J9 CURR OPIN PSYCHIATR
JI Curr. Opin. Psychiatr.
PD MAR
PY 2011
VL 24
IS 2
BP 168
EP 172
DI 10.1097/YCO.0b013e3283438028
PG 5
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 715IH
UT WOS:000286876300014
PM 21285706
DA 2025-06-11
ER

PT J
AU Packard, AEB
   Ghosal, S
   Herman, JP
   Woods, SC
   Ulrich-Lai, YM
AF Packard, Amy E. B.
   Ghosal, Sriparna
   Herman, James P.
   Woods, Stephen C.
   Ulrich-Lai, Yvonne M.
TI Chronic variable stress improves glucose tolerance in rats with
   sucrose-induced prediabetes
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE Chronic stress; Glucose tolerance; Type 2 diabetes; Insulin
ID DIABETIC FATTY RAT; INDUCED PROLONGED STRESS; INSULIN-RESISTANCE;
   FOOD-INTAKE; METABOLIC SYNDROME; GLYCEMIC CONTROL; ADRENAL AXIS;
   OBESITY; MELLITUS; LEPTIN
AB The incidence of type-2 diabetes (T2D) and the burden it places on individuals, as well as society as a whole, compels research into the causes, factors and progression of this disease. Epidemiological studies suggest that chronic stress exposure may contribute to the development and progression of T2D in human patients. To address the interaction between chronic stress and the progression of T2D, we developed a dietary model of the prediabetic state in rats utilizing unlimited access to 30% sucrose solution (in addition to unlimited access to normal chow and water), which led to impaired glucose tolerance despite elevated insulin levels. We then investigated the effects of a chronic variable stress paradigm (CVS; twice daily exposure to an unpredictable stressor for 2 weeks) on metabolic outcomes in this prediabetic model. Chronic stress improved glucose tolerance in prediabetic rats following a glucose challenge. Importantly, pair-fed control groups revealed that the beneficial effect of chronic stress did not result from the decreased food intake or body weight gain that occurred during chronic stress. The present work suggests that chronic stress in rodents can ameliorate the progression of diet-induced prediabetic disease independent of chronic stress-induced decreases in food intake and body weight. (C) 2014 Elsevier Ltd. All rights reserved.
C1 Univ Cincinnati, Dept Psychiat & Behav Neurosci, Cincinnati, OH 45237 USA.
C3 University System of Ohio; University of Cincinnati
RP Packard, AEB (corresponding author), Univ Cincinnati, Dept Psychiat & Behav Neurosci, 2180 E Galbraith Rd ML0506, Cincinnati, OH 45237 USA.
EM amy.packard@uc.edu
RI ; Packard, Amy/I-5405-2013; Herman, James/D-4960-2015
OI Ghosal, Sriparna/0000-0003-4471-6230; Packard, Amy/0000-0003-1057-8853;
   Herman, James/0000-0003-3571-2406; Ulrich-Lai,
   Yvonne/0000-0002-9245-0919
FU  [K01 DK078906];  [R01 DK091425]
FX This work was supported by K01 DK078906 (Y.M.U.) and R01 DK091425
   (Y.M.U.).
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NR 49
TC 33
Z9 36
U1 0
U2 16
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD SEP
PY 2014
VL 47
BP 178
EP 188
DI 10.1016/j.psyneuen.2014.05.016
PG 11
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA AM2PY
UT WOS:000339694500019
PM 25001967
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Jurgonski, A
   Juskiewicz, J
   Zdunczyk, Z
   Król, B
AF Jurgonski, Adam
   Juskiewicz, Jerzy
   Zdunczyk, Zenon
   Krol, Boguslaw
TI Caffeoylquinic acid-rich extract from chicory seeds improves glycemia,
   atherogenic index, and antioxidant status in rats
SO NUTRITION
LA English
DT Article
DE Chicory; Caffeoylquinic acids; Chlorogenic acid; Rutin; The metabolic
   syndrome
ID CYNARA-SCOLYMUS L.; OXIDATIVE STRESS; BIOLOGICAL-PROPERTIES; BRAZILIAN
   PROPOLIS; PHENOLIC-COMPOUNDS; CHLOROGENIC ACID; IN-VIVO; FRUCTOSE;
   IDENTIFICATION; RUTIN
AB Objective: Comparison of the effects of a high-fructose diet supplemented with rutin, a phenolic compound with well-recognized bioavailability and bioactivity, and a chicory (Cichorium intybus L.) seed extract rich in caffeoylquinic acids (CQA) on gut physiology and the development of disorders related to metabolic syndrome.
   Methods: A 28-d experiment was conducted on 32 young male Wistar rats. In comparison with control rats fed a standard corn starch diet (group C), the experimental group (group E) was fed a diet with an increased content of cholesterol and fructose (to 1% and 66% of the diet, respectively), as well as with oxidized soybean oil. Rats from the other two experimental groups were administered the same diet as group E during the first 2 wk of feeding, whereas at the beginning of the last 2 wk, the diet was enriched with rutin (group ER) or the CQA-rich ethanol extract from chicory seeds (9.6% of CQA, group EC), so the amount of added phenolics was equal in both dietary groups (0.15%).
   Results: The diet administered in group E caused hyperglycemia and increased blood serum atherogenicity in rats, but did not induce other manifestations of the metabolic syndrome, i.e., dyslipidemia and oxidative stress. Additionally, it affected gut physiology through increasing mucosal sucrase activity and disturbing fermentative processes in the cecum, such as the production of short-chain fatty acids and the activity of microbial enzymes. Similarly to rutin, the dietary addition of the chicory seed extract improved glycemia, which was comparable to that determined in group C. In addition, the extract was found to decrease the atherogenic index to the level observed in group C and to increase blood antioxidant status. Both dietary supplements reduced the content of thiobarbituric acid-reactive substances in kidney and heart tissue when compared with group E.
   Conclusion: The potential efficacy of the CQA-rich extract from chicory seeds in improving diet-induced metabolic disturbances proved to be better than that of rutin; thus, the extract might be considered as a dietary supplement for carrying out clinical trials. (C) 2012 Elsevier Inc. All rights reserved.
C1 [Jurgonski, Adam; Juskiewicz, Jerzy; Zdunczyk, Zenon] Polish Acad Sci, Div Food Sci, Inst Anim Reprod & Food Res, Olsztyn, Poland.
   [Krol, Boguslaw] Tech Univ Lodz, Inst Chem Technol Food, PL-90924 Lodz, Poland.
C3 Polish Academy of Sciences; Institute of Animal Reproduction & Food
   Research of the Polish Academy of Sciences; Lodz University of
   Technology
RP Jurgonski, A (corresponding author), Polish Acad Sci, Div Food Sci, Inst Anim Reprod & Food Res, Olsztyn, Poland.
EM a.jurgonski@pan.olsztyn.pl
RI JURGONSKI, Adam/A-5864-2009; ZDUNCZYK, Zenon/H-7272-2017; JUSKIEWICZ,
   Jerzy/H-7193-2017
OI JURGONSKI, Adam/0000-0003-3524-3259; ZDUNCZYK,
   Zenon/0000-0002-0640-7552; JUSKIEWICZ, Jerzy/0000-0003-0068-5970
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NR 42
TC 37
Z9 41
U1 1
U2 41
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0899-9007
EI 1873-1244
J9 NUTRITION
JI Nutrition
PD MAR
PY 2012
VL 28
IS 3
BP 300
EP 306
DI 10.1016/j.nut.2011.06.010
PG 7
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 895TL
UT WOS:000300519200014
PM 22014632
DA 2025-06-11
ER

PT J
AU Catalano, PM
   Shankar, K
AF Catalano, Patrick M.
   Shankar, Kartik
TI Obesity and pregnancy: mechanisms of short term and long term adverse
   consequences for mother and child
SO BMJ-BRITISH MEDICAL JOURNAL
LA English
DT Review
ID BODY-MASS INDEX; GESTATIONAL WEIGHT-GAIN; OF-MEDICINE RECOMMENDATIONS;
   LIFE-STYLE INTERVENTION; MATERNAL OBESITY; DENSITY-LIPOPROTEIN;
   METABOLIC SYNDROME; CESAREAN DELIVERY; FOLLICULAR-FLUID; AMINO-ACID
AB Obesity is the most common medical condition in women of reproductive age. Obesity during pregnancy has short term and long term adverse consequences for both mother and child. Obesity causes problems with infertility, and in early gestation it causes spontaneous pregnancy loss and congenital anomalies. Metabolically, obese women have increased insulin resistance in early pregnancy, which becomes manifest clinically in late gestation as glucose intolerance and fetal overgrowth. At term, the risk of cesarean delivery and wound complications is increased. Postpartum, obese women have an increased risk of venous thromboembolism, depression, and difficulty with breast feeding. Because 50-60% of overweight or obese women gain more than recommended by Institute of Medicine gestational weight guidelines, postpartum weight retention increases future cardiometabolic risks and prepregnancy obesity in subsequent pregnancies. Neonates of obese women have increased body fat at birth, which increases the risk of childhood obesity. Although there is no unifying mechanism responsible for the adverse perinatal outcomes associated with maternal obesity, on the basis of the available data, increased prepregnancy maternal insulin resistance and accompanying hyperinsulinemia, inflammation, and oxidative stress seem to contribute to early placental and fetal dysfunction. We will review the pathophysiology underlying these data and try to shed light on the specific underlying mechanisms
C1 [Catalano, Patrick M.] MetroHlth Med Ctr, Ctr Reprod Hlth, Dept Obstet & Gynecol, Cleveland, OH USA.
   [Catalano, Patrick M.] Case Western Reserve Univ, Cleveland, OH 44106 USA.
   [Shankar, Kartik] Univ Arkansas Med Sci, Arkansas Childrens Nutr Ctr, Little Rock, AR 72205 USA.
   [Shankar, Kartik] Univ Arkansas Med Sci, Dept Pediat, Little Rock, AR 72205 USA.
C3 MetroHealth System; University System of Ohio; Case Western Reserve
   University; University of Arkansas System; University of Arkansas
   Medical Sciences; University of Arkansas System; University of Arkansas
   Medical Sciences
RP Catalano, PM (corresponding author), MetroHlth Med Ctr, Ctr Reprod Hlth, Dept Obstet & Gynecol, Cleveland, OH USA.; Catalano, PM (corresponding author), Case Western Reserve Univ, Cleveland, OH 44106 USA.
EM pcatalano@metrohealth.org
RI Catalano, Patrick/GVR-9069-2022
OI Shankar, Kartik/0000-0002-7964-9026
FU Eunice Kennedy Shriver National Institute of Child Health and
   development [HD-11089-19]; USDA Agricultural Research Service CRIS
   [625151000-010-05S]
FX The authors are supported in part by the following grants: Eunice
   Kennedy Shriver National Institute of Child Health and development
   HD-11089-19 (PMC) and USDA Agricultural Research Service CRIS
   625151000-010-05S (KS).
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NR 193
TC 711
Z9 768
U1 14
U2 186
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 0959-535X
EI 1756-1833
J9 BMJ-BRIT MED J
JI BMJ-British Medical Journal
PD FEB 8
PY 2017
VL 356
AR j1
DI 10.1136/bmj.j1
PG 16
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA EL4FX
UT WOS:000394578200002
PM 28179267
OA Green Published
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Liu, ML
   Park, S
AF Liu, Meiling
   Park, Sunmin
TI A Causal Relationship between Vitamin C Intake with Hyperglycemia and
   Metabolic Syndrome Risk: A Two-Sample Mendelian Randomization Study
SO ANTIOXIDANTS
LA English
DT Article
DE vitamin C; metabolic syndrome; hyperglycemia; hypertension; type 2
   diabetes; Mendelian randomization
ID OXIDATIVE STRESS; ASSOCIATION; DISEASE; HEALTH
AB Excessive oxidative stress can contribute to metabolic syndrome (MetS), and antioxidants can protect against its development. Vitamin C (VC) is a well-known antioxidant, and observational studies have associated a deficiency with an increased MetS risk. This study tested the hypothesis that dietary VC intake caused an inverse relation of MetS and its components risk using a two-sample Mendelian randomization (MR) method in adults >= 40 years in a city hospital-based (n = 58,701) and Ansan/Ansung plus rural (n = 13,598) cohorts. Independent genetic variants associated with dietary VC intake were explored using a genome-wide association study (GWAS) with significance levels of p < 5 x 10(-5) and linkage disequilibrium (r2 threshold of 0.001), after adjusting for the covariates related to MetS, in a city hospital-based cohort (n = 52,676) excluding the participants having vitamin supplementation. MR methods, including inverse-variance weighting (IVW), weighted median, MR-Egger, and weighted model, were used to determine the causal relationship between the dietary VC intake and the risk of MetS and its components in Ansan/Ansung plus rural cohorts (n = 11,733). Heterogeneity and leave-one-out sensitivity analyses were conducted. Energy intake, as well as other nutrient intakes, were significantly lower in the low VC intake group than in the high VC intake group, but the incidence of MetS and its components, including hyperglycemia, hypertriglyceridemia, and hypertension, was observationally higher in inadequate low VC intake in the combined cohorts. In MR analysis, insufficient dietary VC intake increased the risk of MetS, hyperglycemia, hypertriglyceridemia, and hypertension in an IVW (p < 0.05). In contrast, only the serum fasting blood glucose concentration was significantly associated with VC intake in weight median analysis (p < 0.05), but there was no significant association of low dietary VC with MetS and its components in MR-Egger. There was no likelihood of heterogeneity and horizontal pleiotropy in MetS and its components. A single genetic variant did not affect their association in the leave-one-out sensitivity analysis. In conclusion, insufficient dietary VC intake potentially increased the MetS and hyperglycemia risk in Asian adults. Low VC intake can contribute to increasing type 2 diabetes incidence in Asians.
C1 [Liu, Meiling; Park, Sunmin] Hoseo Univ, Obes Diabet Res Ctr, Dept Food & Nutr, Asan 31499, South Korea.
C3 Hoseo University
RP Park, S (corresponding author), Hoseo Univ, Obes Diabet Res Ctr, Dept Food & Nutr, Asan 31499, South Korea.
EM 20185752@vision.hoseo.edu; smpark@hoseo.edu
OI Park, Sunmin/0000-0002-6092-8340
FU National Research Foundation of Korea [2019R1A2C1007203]
FX This research was supported by the National Research Foundation of Korea
   (2019R1A2C1007203).
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Z9 17
U1 0
U2 7
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD MAY
PY 2022
VL 11
IS 5
AR 857
DI 10.3390/antiox11050857
PG 18
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA 1P2XK
UT WOS:000801877800001
PM 35624721
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Bartoli, F
   Crocamo, C
   Bava, M
   Castagna, G
   Di Brita, C
   Riboldi, I
   Trotta, G
   Verrengia, E
   Clerici, M
   Carrá, G
AF Bartoli, Francesco
   Crocamo, Cristina
   Bava, Mattia
   Castagna, Gloria
   Di Brita, Carmen
   Riboldi, Ilaria
   Trotta, Giulia
   Verrengia, Enrica
   Clerici, Massimo
   Carra, Giuseppe
TI Testing the association of serum uric acid levels with behavioral and
   clinical characteristics in subjects with major affective disorders: A
   cross-sectional study
SO PSYCHIATRY RESEARCH
LA English
DT Article
DE Behavior; Bipolar disorder; Major depression; Uric acid
ID BIPOLAR DISORDER; METABOLIC SYNDROME; DEPRESSIVE DISORDER; OXIDATIVE
   STRESS; METAANALYSIS; RISK; ALLOPURINOL; AGGRESSION; SEVERITY; HISTORY
AB Previous research has hypothesized a role for serum uric acid as a marker of mental disorders and related behaviors, possibly due to its link with purinergic transmission and antioxidant activity. We tested the association of serum uric acid levels with specific behavioral and clinical characteristics in 99 individuals suffering from major affective disorders. Subjects were assessed and interviewed using the Kessler Psychological Distress Scale, the Columbia-Suicide Severity Rating Scale, the Modified Overt Aggression Scale, and the Barratt Impulsiveness Scale. We found that psychological distress and suicidal ideation severity were associated with lower uric acid serum levels. On the other hand, verbal aggression and history of violence were associated with higher levels of serum uric acid. However, according to linear regression analyses, there were no behavioral and clinical characteristics independently associated with serum uric acid. Serum uric acid levels were influenced by creatinine and BMI, as well as, possibly, by white blood cells count and gender. Despite some limitations, these results suggest that no behavioral / clinical features are associated with variations of serum uric acid, which rather seem attributable to specific biochemical and metabolic parameters. Nevertheless, the role of purinergic system in different mental disorders and behavioral abnormalities, deserves further research.
C1 [Bartoli, Francesco; Crocamo, Cristina; Bava, Mattia; Castagna, Gloria; Di Brita, Carmen; Riboldi, Ilaria; Trotta, Giulia; Verrengia, Enrica; Clerici, Massimo; Carra, Giuseppe] Univ Milano Bicocca, Dept Med & Surg, Via Cadore 48, I-20900 Monza, Italy.
   [Carra, Giuseppe] UCL, Div Psychiat, 6th Floor,Maple House,149 Tottenham Court Rd, London W1T 7NF, England.
C3 University of Milano-Bicocca; University of London; University College
   London
RP Bartoli, F (corresponding author), Univ Milano Bicocca, Dept Med & Surg, Via Cadore 48, I-20900 Monza, Italy.
EM f.bartoli@campus.unimib.it
RI Crocamo, Cristina/I-4355-2019; Riboldi, Ilaria/ABF-5800-2020; Clerici,
   Massimo/U-3074-2019; Carra, Giuseppe/C-6091-2012; Bartoli,
   Francesco/K-5755-2016; Dakanalis Antonios Ntakanales, MD, MSc, PsyD,
   PhD, FNASc, Antonios/I-5105-2013; Crocamo, Cristina/B-5404-2014
OI Carra, Giuseppe/0000-0002-6877-6169; Bartoli,
   Francesco/0000-0003-2612-4119; Dakanalis Antonios Ntakanales, MD, MSc,
   PsyD, PhD, FNASc, Antonios/0000-0002-2328-3862; Clerici,
   Massimo/0000-0001-8769-6474; Riboldi, Ilaria/0000-0002-8188-800X;
   Crocamo, Cristina/0000-0002-2979-2107
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NR 42
TC 13
Z9 13
U1 2
U2 13
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0165-1781
EI 1872-7123
J9 PSYCHIAT RES
JI Psychiatry Res.
PD NOV
PY 2018
VL 269
BP 118
EP 123
DI 10.1016/j.psychres.2018.08.039
PG 6
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA HA0MS
UT WOS:000449902700020
PM 30145291
DA 2025-06-11
ER

PT J
AU Askin, L
   Uzel, KE
   Tanriverdi, O
   Turkmen, S
AF Askin, Lutfu
   Uzel, Kader Eliz
   Tanriverdi, Okan
   Turkmen, Serdar
TI Serum Irisin: Pathogenesis and Clinical Research in Cardiovascular
   Diseases
SO CARDIOVASCULAR INNOVATIONS AND APPLICATIONS
LA English
DT Review
DE insulin resistance; irisin; cardiovascular diseases; body mass index
ID TYPE-2 DIABETES-MELLITUS; MYOCARDIAL-INFARCTION; ASSOCIATION;
   ADIPOCYTES; HEALTHY; MYOKINE; MARKER; INJURY
AB Recently, muscular function/dysfunction has gained importance in the maintenance of metabolic homeostasis in cardiovascular diseases. Skeletal muscle plays a vital role in coordinating the activity and metabolism of endocrine organs by secreting many myokines, especially irisin. Irisin is a polypeptide hormone consisting of 112 amino acids secreted into the blood from muscle and adipose tissues. Serum irisin levels are associated with cardiometabolic risk factors such as obesity and insulin resistance as defined by homeostatic model assessment. Irisin reduces endothelial damage by inhibiting inflammation and oxidative stress, thus playing a key role in maintaining endothelial cell function. Unsurprisingly, low irisin levels cause endothelial dysfunction and increase the incidence of atherosclerosis. We aimed to summarize the studies on this issue since we have not found any review in the literature on the role of serum irisin levels in the process of atherosclerosis and other cardiovascular events in cardiovascular diseases.
C1 [Askin, Lutfu; Uzel, Kader Eliz; Tanriverdi, Okan; Turkmen, Serdar] Adiyaman Educ & Res Hosp, Dept Cardiol, TR-2230 Adiyaman, Turkey.
RP Askin, L (corresponding author), Adiyaman Educ & Res Hosp, Dept Cardiol, TR-2230 Adiyaman, Turkey.
EM lutfuaskin23@gmail.com
RI Türkmen, Serdar/ABF-8271-2021; Tanriverdi, Ozgur/M-2172-2015; askin,
   lutfu/H-1047-2018
OI askin, lutfu/0000-0001-7768-2562
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NR 49
TC 5
Z9 5
U1 0
U2 10
PU COMPUSCRIPT
PI SHANNON
PA BAY 11A, SHANNON INDUSTRIAL EST, SHANNON, CLARE 00000, IRELAND
SN 2009-8618
EI 2009-8782
J9 CARDIOVASC INNOV APP
JI Cardiovasc. Innov. Appl.
PD JAN 1
PY 2020
VL 4
IS 3
BP 195
EP 200
DI 10.15212/CVIA.2019.0569
PG 6
WC Cardiac & Cardiovascular Systems
WE Emerging Sources Citation Index (ESCI)
SC Cardiovascular System & Cardiology
GA KY5SH
UT WOS:000522631900005
OA gold
DA 2025-06-11
ER

PT J
AU Vijayan, M
   Reddy, PH
AF Vijayan, Murali
   Reddy, P. Hemachandra
TI Peripheral biomarkers of stroke: Focus on circulatory microRNAs
SO BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
LA English
DT Review
DE Stroke; Vascular dementia; Alzheimer's disease; Circulatory microRNA;
   Serum; Plasma; Protein biomarker
ID C-REACTIVE PROTEIN; TRANSIENT ISCHEMIC ATTACK; PHOSPHOLIPASE A(2);
   INFARCT VOLUME; BIOCHEMICAL MARKERS; HEART-DISEASE; SERUM S100B; RISK;
   BRAIN; EXPRESSION
AB Stroke is the second leading cause of death in the world. Stroke occurs when blood flow stops, and that stoppage results in reduced oxygen supply to neurons in the brain. The occurrence of stroke increases with age, but anyone at any age can suffer from stroke. Recent research has implicated multiple cellular changes in stroke patients, including oxidative stress and mitochondrial dysfunction, inflammatory responses, and changes in mRNA and proteins. Recent research has also revealed that stroke is associated with modifiable and non-modifiable risk factors. Stroke can be controlled by modifiable risk factors, including diet, cardiovascular, hypertension, smoking, diabetes, obesity, metabolic syndrome, depression and traumatic brain injury. Stroke is the major risk factor for vascular dementia (VaD) and Alzheimer's disease (AD). The purpose of this article is to review the latest developments in research efforts directed at identifying 1) latest developments in identifying biomarkers in peripheral and central nervous system tissues, 2) changes in microRNAs (miRNAs) in patients with stroke, 3) miRNA profile and function in animal brain, and 4) protein biomarkers in ischemic stroke. This article also reviews research investigating circulatory miRNAs as peripheral biomarkers of stroke. (C) 2016 Elsevier B.V. All rights reserved.
C1 [Vijayan, Murali; Reddy, P. Hemachandra] Texas Tech Univ, Garrison Inst Aging, Hlth Sci Ctr, 3601 4th St,MS 9424,4A 124, Lubbock, TX 79430 USA.
   [Reddy, P. Hemachandra] Texas Tech Univ, Cell Biol & Biochem, Hlth Sci Ctr, 3601 4th St,MS 9424, Lubbock, TX 79430 USA.
   [Reddy, P. Hemachandra] Texas Tech Univ, Neurosci & Pharmacol, Hlth Sci Ctr, 3601 4th St,MS 9424, Lubbock, TX 79430 USA.
   [Reddy, P. Hemachandra] Texas Tech Univ, Neurol, Hlth Sci Ctr, 3601 4th St,MS 9424, Lubbock, TX 79430 USA.
   [Reddy, P. Hemachandra] Texas Tech Univ, Hlth Sci Ctr, Speech Sci Dept, 3601 4th St,MS 9424, Lubbock, TX 79430 USA.
   [Reddy, P. Hemachandra] Texas Tech Univ, Hlth Sci Ctr, Language & Hearing Sci Dept, 3601 4th St,MS 9424, Lubbock, TX 79430 USA.
   [Reddy, P. Hemachandra] Texas Tech Univ, Hlth Sci Ctr, Garrison Inst Aging, South West Campus,6630 S Quaker Ste E,MS 7495, Lubbock, TX 79413 USA.
C3 Texas Tech University System; Texas Tech University Health Sciences
   Center Lubbock; Texas Tech University System; Texas Tech University
   Health Sciences Center Lubbock; Texas Tech University System; Texas Tech
   University Health Sciences Center Lubbock; Texas Tech University System;
   Texas Tech University Health Sciences Center Lubbock; Texas Tech
   University System; Texas Tech University Health Sciences Center Lubbock;
   Texas Tech University System; Texas Tech University Health Sciences
   Center Lubbock; Texas Tech University System; Texas Tech University
   Health Sciences Center Lubbock
RP Reddy, PH (corresponding author), Texas Tech Univ, Garrison Inst Aging, Hlth Sci Ctr, 3601 4th St,MS 9424,4A 124, Lubbock, TX 79430 USA.
EM hemachandra.reddy@ttuhsc.edu
FU National Institutes of Health [AG042178, AG47812]; Garrison Family
   Foundation
FX Work presented in this article is supported by National Institutes of
   Health grants - AG042178 and AG47812 and Garrison Family Foundation.
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NR 89
TC 102
Z9 109
U1 0
U2 59
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0925-4439
EI 1879-260X
J9 BBA-MOL BASIS DIS
JI Biochim. Biophys. Acta-Mol. Basis Dis.
PD OCT
PY 2016
VL 1862
IS 10
BP 1984
EP 1993
DI 10.1016/j.bbadis.2016.08.003
PG 10
WC Biochemistry & Molecular Biology; Biophysics; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Cell Biology
GA DU7RW
UT WOS:000382413300014
PM 27503360
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Allegrini, S
   Garcia-Gil, M
   Pesi, R
   Camici, M
   Tozzi, MG
AF Allegrini, Simone
   Garcia-Gil, Mercedes
   Pesi, Rossana
   Camici, Marcella
   Tozzi, Maria Grazia
TI The Good, the Bad and the New about Uric Acid in Cancer
SO CANCERS
LA English
DT Review
DE uric acid; hyperuricemia; oxidative stress; cancer; fructose; xanthine
   oxidoreductase; AKT; AMPK; mTOR; uricase
ID XANTHINE OXIDOREDUCTASE; MOLECULAR PHYSIOLOGY; METABOLIC SYNDROME;
   HEPATIC STEATOSIS; OXIDATIVE STRESS; PURINE SYNTHESIS; GENE-EXPRESSION;
   ADIPOSE-TISSUE; DANGER SIGNAL; URATE OXIDASE
AB Simple Summary The concentration of uric acid in blood is sex-, age- and diet-dependent and is maintained close to its maximal solubility, indicating that it plays some important role. Indeed, it has been demonstrated that, at physiological concentrations, uric acid is a powerful antioxidant and is a scavenger of singlet oxygen and radicals. At high intracellular concentration, uric acid has been demonstrated to act as a pro-oxidant molecule. Recently, uric acid has been reported to affect the properties of several proteins involved in metabolic regulation and signaling, and the relationship between uric acid and cancer has been extensively investigated. In this review, we present the most recent results on the positive and negative effects played by uric acid in cancer and some new findings and hypotheses about the implication of this metabolite in the pathogenesis of several diseases such as metabolic syndrome, diabetes, and inflammation, thus favoring the development of cancer. Uric acid is the final product of purine catabolism in man and apes. The serum concentration of uric acid is sex-, age- and diet-dependent and is maintained close to its maximal solubility, indicating that it plays some important role. Indeed, it has been demonstrated that, at physiological concentrations, uric acid is a powerful antioxidant, while at high intracellular concentrations, it is a pro-oxidant molecule. In this review, we describe the possible causes of uric acid accumulation or depletion and some of the metabolic and regulatory pathways it may impact. Particular attention has been given to fructose, which, because of the complex correlation between carbohydrate and nucleotide metabolism, causes uric acid accumulation. We also present recent results on the positive and negative effects played by uric acid in cancer and some new findings and hypotheses about the implication of this metabolite in a variety of signaling pathways, which can play a role in the pathogenesis of diseases such as metabolic syndrome, diabetes, and inflammation, thus favoring the development of cancer. The loss of uricase in Homo sapiens and great apes, although exposing these species to the potentially adverse effects of uric acid, appears to be associated with evolutionary advantages.
C1 [Allegrini, Simone; Pesi, Rossana; Camici, Marcella; Tozzi, Maria Grazia] Univ Pisa, Unita Biochim, Dipartimento Biol, Via San Zeno 51, I-56127 Pisa, Italy.
   [Allegrini, Simone; Garcia-Gil, Mercedes] Univ Pisa, Interdept Res Ctr Nutrafood Nutraceut & Food Hlth, I-56126 Pisa, Italy.
   [Allegrini, Simone; Garcia-Gil, Mercedes] Univ Pisa, CISUP, Ctr Integraz Strumentaz, I-56127 Pisa, Italy.
   [Garcia-Gil, Mercedes] Univ Pisa, Unita Fisiol Gen, Dipartimento Biol, Via San Zeno 31, I-56127 Pisa, Italy.
C3 University of Pisa; University of Pisa; University of Pisa; University
   of Pisa
RP Allegrini, S (corresponding author), Univ Pisa, Unita Biochim, Dipartimento Biol, Via San Zeno 51, I-56127 Pisa, Italy.; Allegrini, S (corresponding author), Univ Pisa, Interdept Res Ctr Nutrafood Nutraceut & Food Hlth, I-56126 Pisa, Italy.; Allegrini, S (corresponding author), Univ Pisa, CISUP, Ctr Integraz Strumentaz, I-56127 Pisa, Italy.
EM simone.allegrini@unipi.it
RI Pesi, Rossana/AAQ-3102-2020; Allegrini, Simone/F-9192-2010; TOZZI, MARIA
   GRAZIA/A-6018-2016
OI GARCIA GIL, MARIA de las MERCEDES/0000-0002-1344-2786; Allegrini,
   Simone/0000-0002-7005-654X; TOZZI, MARIA GRAZIA/0000-0002-1075-7096;
   Pesi, Rossana/0000-0003-4785-7282; CAMICI, MARCELLA/0000-0001-8133-8414
FU University of Pisa
FX This work was supported by local funding from the University of Pisa (ex
   60%) to S.A and M.G.-G.
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NR 140
TC 40
Z9 41
U1 4
U2 24
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6694
J9 CANCERS
JI Cancers
PD OCT
PY 2022
VL 14
IS 19
AR 4959
DI 10.3390/cancers14194959
PG 22
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA 5G2DX
UT WOS:000866815800001
PM 36230882
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Alvarez-Mercado, AI
   Rojano-Alfonso, C
   Micó-Carnero, M
   Caballeria-Casals, A
   Peralta, C
   Casillas-Ramírez, A
AF Alvarez-Mercado, Ana Isabel
   Rojano-Alfonso, Carlos
   Mico-Carnero, Marc
   Caballeria-Casals, Albert
   Peralta, Carmen
   Casillas-Ramirez, Arani
TI New Insights Into the Role of Autophagy in Liver Surgery in the Setting
   of Metabolic Syndrome and Related Diseases
SO FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
LA English
DT Review
DE autophagy; metabolic syndrome; ischemia-reperfusion; liver surgery;
   transplantation
ID ISCHEMIA-REPERFUSION INJURY; ENDOPLASMIC-RETICULUM STRESS; HEPATIC
   ISCHEMIA/REPERFUSION INJURY; ACTIVATED PROTEIN-KINASE; RAT STEATOTIC
   LIVER; FATTY LIVER; INSULIN-RESISTANCE; ANGIOTENSIN-II; MOUSE-LIVER;
   SIRTUIN 1
AB Visceral obesity is an important component of metabolic syndrome, a cluster of diseases that also includes diabetes and insulin resistance. A combination of these metabolic disorders damages liver function, which manifests as non-alcoholic fatty liver disease (NAFLD). NAFLD is a common cause of abnormal liver function, and numerous studies have established the enormously deleterious role of hepatic steatosis in ischemia-reperfusion (I/R) injury that inevitably occurs in both liver resection and transplantation. Thus, steatotic livers exhibit a higher frequency of post-surgical complications after hepatectomy, and using liver grafts from donors with NAFLD is associated with an increased risk of post-surgical morbidity and mortality in the recipient. Diabetes, another MetS-related metabolic disorder, also worsens hepatic I/R injury, and similar to NAFLD, diabetes is associated with a poor prognosis after liver surgery. Due to the large increase in the prevalence of MetS, NAFLD, and diabetes, their association is frequent in the population and therefore, in patients requiring liver resection and in potential liver graft donors. This scenario requires advancement in therapies to improve postoperative results in patients suffering from metabolic diseases and undergoing liver surgery; and in this sense, the bases for designing therapeutic strategies are in-depth knowledge about the molecular signaling pathways underlying the effects of MetS-related diseases and I/R injury on liver tissue. A common denominator in all these diseases is autophagy. In fact, in the context of obesity, autophagy is profoundly diminished in hepatocytes and alters mitochondrial functions in the liver. In insulin resistance conditions, there is a suppression of autophagy in the liver, which is associated with the accumulation of lipids, being this is a risk factor for NAFLD. Also, oxidative stress occurring in hepatic I/R injury promotes autophagy. The present review aims to shed some light on the role of autophagy in livers undergoing surgery and also suffering from metabolic diseases, which may lead to the discovery of effective therapeutic targets that could be translated from laboratory to clinical practice, to improve postoperative results of liver surgeries when performed in the presence of one or more metabolic diseases.
C1 [Alvarez-Mercado, Ana Isabel] Sch Pharm, Dept Biochem & Mol Biol 2, Granada, Spain.
   [Alvarez-Mercado, Ana Isabel] Parque Tecnol Ciencias Salud, Inst Nutr & Food Technol Jose Mataix, Biomed Res Ctr, Granada, Spain.
   [Alvarez-Mercado, Ana Isabel] Complejo Hosp Univ Granada, Inst Invest Biosanitaria Ibs GRANADA, Granada, Spain.
   [Rojano-Alfonso, Carlos; Mico-Carnero, Marc; Caballeria-Casals, Albert; Peralta, Carmen] Inst Invest Biomed August Pi & Sunyer IDIBAPS, Barcelona, Spain.
   [Casillas-Ramirez, Arani] Hosp Reg Alta Especialidad Ciudad Victoria Bicent, Ciudad Victoria, Tamaulipas, Mexico.
   [Casillas-Ramirez, Arani] Univ Autonoma Tamaulipas, Fac Med & Ingn Sistemas Comp Matamoros, Matamoros, Mexico.
C3 Instituto de Investigacion Biosanitaria IBS Granada; University of
   Granada; University of Barcelona; Hospital Clinic de Barcelona; IDIBAPS;
   Universidad Autonoma de Tamaulipas
RP Peralta, C (corresponding author), Inst Invest Biomed August Pi & Sunyer IDIBAPS, Barcelona, Spain.; Casillas-Ramírez, A (corresponding author), Hosp Reg Alta Especialidad Ciudad Victoria Bicent, Ciudad Victoria, Tamaulipas, Mexico.; Casillas-Ramírez, A (corresponding author), Univ Autonoma Tamaulipas, Fac Med & Ingn Sistemas Comp Matamoros, Matamoros, Mexico.
EM cperalta@clinic.cat; aranyc@yahoo.com
RI Alvarez, Ana/GXW-0690-2022; CASILLAS-RAMIREZ, ARANI/LFS-7121-2024;
   Peralta, Carmen/M-8170-2014; Alvarez-Mercado, Ana I./C-3466-2019
OI Rojano Alfonso, Carlos/0000-0001-5035-9626; Peralta,
   Carmen/0000-0002-5767-0676; CASILLAS-RAMIREZ, ARANI/0000-0001-7533-1478;
   Caballeria Casals, Albert/0000-0003-2954-4477; Alvarez-Mercado, Ana
   I./0000-0002-8476-9970
FU Ministerio de Ciencia, Innovacion y Universidades Madrid, Spain
   [RTI2018-095114-B-I00]; European Union (Fondos FEDER, "una manera de
   hacer Europa"); CERCA Program/Generalitat de Catalunya; Secretaria d'
   Universitats I Recerca del Departament d' Economia I Coneixement
   Barcelona, Spain [2017_SGR_551]; COST action [CA17103, CA17112, CA17121,
   CA17126]; Consejo Nacional de Ciencia y Tecnologia (CONACYT), Fondo
   Sectorial de Investigacion para la Educacion, Mexico [257743]; FCT
   (Fundacio Catalana de trasplantament), Spain; Academy of Finland (AKA)
   [257743] Funding Source: Academy of Finland (AKA)
FX This research was funded by the Ministerio de Ciencia, Innovacion y
   Universidades (Project Grant RTI2018-095114-B-I00) Madrid, Spain;
   European Union (Fondos FEDER, "una manera de hacer Europa"); CERCA
   Program/Generalitat de Catalunya; the Secretaria d' Universitats I
   Recerca del Departament d' Economia I Coneixement (Project Grant
   2017_SGR_551) Barcelona, Spain, by the COST action Programs CA17103
   (DARTER), CA17112 (PRO-EURO-DILI-NET), CA17121 (COMULIS), and CA17126
   (TUMIEE), and by the Consejo Nacional de Ciencia y Tecnologia (CONACYT),
   Fondo Sectorial de Investigacion para la Educacion (Project grant
   257743), Mexico. MM-C is the recipient of a fellowship from FCT
   (Fundacio Catalana de trasplantament), Spain.
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NR 205
TC 9
Z9 10
U1 0
U2 10
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-634X
J9 FRONT CELL DEV BIOL
JI Front. Cell. Dev. Biol.
PD JUN 1
PY 2021
VL 9
AR 670273
DI 10.3389/fcell.2021.670273
PG 31
WC Cell Biology; Developmental Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Developmental Biology
GA SS0NL
UT WOS:000661439100001
PM 34141709
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Byrne, ML
   Horne, S
   O'Brien-Simpson, NM
   Walsh, KA
   Reynolds, EC
   Schwartz, OS
   Whittle, S
   Simmons, JG
   Sheeber, L
   Allen, NB
AF Byrne, Michelle L.
   Horne, Sally
   O'Brien-Simpson, Neil M.
   Walsh, Katrina A.
   Reynolds, Eric C.
   Schwartz, Orli S.
   Whittle, Sarah
   Simmons, Julian G.
   Sheeber, Lisa
   Allen, Nicholas B.
TI Associations Between Observed Parenting Behavior and Adolescent
   Inflammation Two and a Half Years Later in a Community Sample
SO HEALTH PSYCHOLOGY
LA English
DT Article
DE adolescence; parenting emotional behavior; inflammation; salivary
   C-reactive protein; family environments
ID C-REACTIVE PROTEIN; EARLY-LIFE; SALIVARY BIOMARKERS; FAMILY
   INTERACTIONS; METABOLIC SYNDROME; IMMUNE FUNCTION; STRESS; DEPRESSION;
   RESPONSES; PREDICT
AB Objective: Family environments have an effect on physical health during adolescence, and a possible underlying mechanism is inflammation. However, little is known about the association between observed parenting behaviors and immune system functioning. The current study examined whether positive and negative emotional parental behaviors observed during family interactions were associated with inflammation in adolescents. Method: Sixty-one parent-adolescent dyads (37 male adolescents, 60.6%; 15 male parents, 24.6%) were observed during 2 laboratory-based interaction tasks designed to elicit positive and conflictual emotional behaviors, respectively. Frequency of aggressive and positive parental behavior was coded. Adolescents were followed up approximately 2.5 years later and salivary concentrations of the inflammatory biomarker C-reactive protein (sCRP) were measured. Results: Controlling for BMI and depressive symptoms, lower sCRP was associated both with greater frequency of positive parental behaviors, t = -3.087, p=.003 and less frequency of aggressive parental behavior (t = 2.087, p=.041) in the conflictual task. Trend associations between positive behavior during the positive task and lower sCRP were also found. Conclusions: This is the first study to show that observed positive parenting is associated with lower levels of inflammation in adolescents.
C1 [Byrne, Michelle L.; Allen, Nicholas B.] Univ Oregon, Dept Psychol, Eugene, OR 97403 USA.
   [Horne, Sally; Schwartz, Orli S.; Allen, Nicholas B.] Univ Melbourne, Melbourne Sch Psychol Sci, Parkville, Vic, Australia.
   [O'Brien-Simpson, Neil M.; Walsh, Katrina A.; Reynolds, Eric C.] Univ Melbourne, Melbourne Dent Sch, Victoria, Parkville, Vic, Australia.
   [Whittle, Sarah; Simmons, Julian G.] Univ Melbourne, Dept Psychiat, Melbourne Neuropsychiat Ctr, Melbourne Sch Psychol Sci, Parkville, Vic, Australia.
   [Whittle, Sarah; Simmons, Julian G.] Melbourne Hlth, Parkville, Vic, Australia.
   [Sheeber, Lisa] Oregon Res Inst, Eugene, OR 97403 USA.
   [Allen, Nicholas B.] Univ Melbourne, Ctr Youth Mental Hlth, Orygen Res Ctr, Parkville, Vic, Australia.
C3 University of Oregon; University of Melbourne; University of Melbourne;
   University of Melbourne; Oregon Research Institute; Orygen, The National
   Centre of Excellence in Youth Mental Health; University of Melbourne
RP Allen, NB (corresponding author), 1227 Univ Oregon, Dept Psychol, Eugene, OR 97403 USA.
EM nallen3@uoregon.edu
RI Schwartz, Orli/ABD-3996-2021; O'Brien-Simpson, Neil/B-2901-2009;
   Whittle, Sarah/I-2200-2014
OI O'Brien-Simpson, Neil/0000-0001-8462-5603; Walsh,
   Katrina/0000-0002-0927-2008; Simmons, Julian G./0000-0002-7228-1847;
   Byrne, Michelle/0000-0002-4180-8095; Schwartz, Orli/0000-0001-7634-3737;
   Whittle, Sarah/0000-0003-3145-1528
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NR 83
TC 11
Z9 12
U1 0
U2 8
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 0278-6133
EI 1930-7810
J9 HEALTH PSYCHOL
JI Health Psychol.
PD JUL
PY 2017
VL 36
IS 7
BP 641
EP 651
DI 10.1037/hea0000502
PG 11
WC Psychology, Clinical; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology
GA EY1FP
UT WOS:000403711500003
PM 28530434
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Gutiérrez-Rojas, L
   Pulido, S
   Azanza, JR
   Bernardo, M
   Rojo, L
   Mesa, FJ
   Martínez-Ortega, JM
AF Gutierrez-Rojas, Luis
   Pulido, Susana
   Azanza, Jose R.
   Bernardo, Miguel
   Rojo, Luis
   Mesa, Francisco J.
   Martinez-Ortega, Jose M.
TI Risk factor assessment and counselling for 12 months reduces metabolic
   and cardiovascular risk in overweight or obese patients with
   schizophrenia spectrum disorders: The CRESSOB study
SO ACTAS ESPANOLAS DE PSIQUIATRIA
LA English
DT Article
DE Schizophrenia; Metabolic Syndrome; Overweight; Cardiovascular Disease
ID INDUCED WEIGHT-GAIN; SYNDROME SCALE PANSS; PSYCHOTIC DISORDERS;
   LIFE-STYLE; ANTIPSYCHOTIC-DRUGS; GLOBAL ASSESSMENT; PHYSICAL ILLNESS;
   PEOPLE; OUTPATIENTS; PREVALENCE
AB Background. Metabolic syndrome (MS) and cardiovascular risk factors (CRF) have been associated with patients with schizophrenia. The main objective is to assess the evolution of CRF and prevalence of MS for 12 months in a cohort of overweight patients diagnosed with schizophrenia schizophreniform disorder or schizoaffective disorder in which the recommendations for the assessment and control of metabolic and cardiovascular risk were applied.
   Methods. The Control of Metabolic and Cardiovascular Risk in Patients with Schizophrenia and Overweight (CRESSOB) study is a 12-month, observational, prospective, open-label, multicentre, naturalistic study including 109 community mental health clinics of Spain. The study included a total of 403 patients, of whom we could collect all variables related to CRF and MS in 366-patients. Of these 366 patients, 286 completed the follow-up, (baseline, months 3, 6 and 12) where they underwent a complete physical examination and a blood test (glucose, cholesterol and triglycerides), they were asked about their health-related habits (smoking, diet and exercise) and they were given a series of recommendations to prevent cardiovascular risk and MS.
   Results. A total of 403 patients were included, 63% men, mean age (mean; (SD)) 40.5 (10.5) years. After 12 months, the study showed statistically significant decrease in weight (p<0.0001), waist circumference (p<0.0001), BMI (p<0.0001), blood glucose (p=0.0034), total cholesterol (p<0.0001), HDL cholesterol (p=0.02), LDL cholesterol (p=0.0023) and triglycerides (p=0.0005). There was a significant reduction in the percentage of smokers (p=0.0057) and in the risk of heart disease at 10 years (p=0.0353).
   Conclusion. Overweight patients with schizophrenia who receive appropriate medical care, including CRF monitoring and control of health-related habits experience improvements with regard to most CRFs.
C1 [Gutierrez-Rojas, Luis] San Cecilio Univ Hosp, Psychiat Serv, Granada, Spain.
   [Pulido, Susana; Mesa, Francisco J.] Pfizer GEP, Med Unit, Madrid, Spain.
   [Azanza, Jose R.] Univ Navarra, Univ Hosp, Invest Unit, Dept Pharmacol, E-31080 Pamplona, Spain.
   [Bernardo, Miguel] IDIBAPS, Barcelona, Spain.
   [Bernardo, Miguel] Hosp Clin Barcelona, Barcelona Clin Schizophrenia Unit, Barcelona, Spain.
   [Bernardo, Miguel] Univ Barcelona, Dept Psychiat & Clin Psychobiol, E-08007 Barcelona, Spain.
   [Rojo, Luis] Hosp La Fe, Dept Unit, E-46009 Valencia, Spain.
   [Martinez-Ortega, Jose M.] Univ Granada, Inst Neurosci, Ctr Biomed Res CIBM, Dept Psychiat, Granada, Spain.
   [Martinez-Ortega, Jose M.] Univ Granada, Inst Neurosci, Ctr Biomed Res CIBM, CTS Res Grp 549, Granada, Spain.
C3 Hospital Universitario San Cecilio; Pfizer; Pfizer Spain; University of
   Navarra; University of Barcelona; Hospital Clinic de Barcelona; IDIBAPS;
   University of Barcelona; Hospital Clinic de Barcelona; University of
   Barcelona; Hospital Universitari i Politecnic La Fe; University of
   Granada; University of Granada
RP Gutiérrez-Rojas, L (corresponding author), Fac Med, Dept Psychiat, Ave Madrid 11, Granada 18071, Spain.
EM gutierrezrojasl@hotmail.com
RI Mesa, Francisco/KRO-3713-2024; Rojas, Luis/AAI-1110-2021; Rojas,
   Luis/B-8732-2013; Azanza Perea, José Ramón/ABG-1593-2021; Bernardo,
   Miquel/P-3049-2015
OI Azanza Perea, Jose Ramon/0000-0003-3190-622X; Bernardo,
   Miquel/0000-0001-8748-6717; Gutierrez-Rojas, Luis/0000-0003-0082-2189
FU Pfizer
FX This study was sponsored by Pfizer. Pfizer contributed to and approved
   the study design and the final draft of the manuscript. A CRO, European
   Biometrics Institute, was engaged by Pfizer to conduct the study,
   including logistics, monitoring, data management, and statistical
   analysis. Pfizer oversaw the entire process of the study.
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NR 57
TC 8
Z9 9
U1 0
U2 8
PU JUAN JOSE LOPEZ-IBOR FOUNDATION
PI MADRID
PA NO 2, MADRID, 28035, SPAIN
SN 1139-9287
EI 1578-2735
J9 ACTAS ESP PSIQUIATRI
JI Actas Esp. Psiquiatri.
PD JAN-FEB
PY 2016
VL 44
IS 1
BP 20
EP 29
PG 10
WC Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA DH0NZ
UT WOS:000372482200003
PM 26905887
DA 2025-06-11
ER

PT J
AU Palomo, I
   Alarcón, M
   Moore-Carrasco, R
   Argilés, JM
AF Palomo, Ivan
   Alarcon, Marcelo
   Moore-Carrasco, Rodrigo
   Argiles, Josep M.
TI Hemostasis alterations in metabolic syndrome (review)
SO INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
LA English
DT Review
DE metabolic syndrome; hemostasis; thrombosis
ID LOW-DENSITY-LIPOPROTEIN; PLASMINOGEN-ACTIVATOR INHIBITOR; CARDIOVASCULAR
   RISK-FACTORS; FACTOR PATHWAY INHIBITOR; CORONARY-HEART-DISEASE;
   C-REACTIVE PROTEIN; INSULIN-RESISTANCE; TISSUE FACTOR; ENDOTHELIAL
   DYSFUNCTION; ANTICARDIOLIPIN ANTIBODIES
AB Metabolic syndrome (MS) is characterized by the presence of at least three of the following alterations: enlargement of the waist diameter, higher levels of arterial pressure, low density lipoprotein cholesterol and glycemia, and reduction of high density lipoprotein cholesterol. The prevalence of MS reaches 23% in young adults, a percentage that increases with age. People with MS have a greater risk of suffering from cardiovascular disease (CVD). The physiopathologic alterations now found to exist in MS are diverse; among them is endothelial dysfunction, which triggers atherogenic lesions and hypercoagulability characterized by alterations of the coagulation factors and the regulatory proteins of fibrinolysis such as the plasminogen activator inhibitor (PAI-1). The increase in oxidative stress and/or the reactive oxygen species in patients with MS is partially related to the oxidation state of the lipoproteins, especially of the low density lipoproteins. This fact favors atherogenesis. Moreover, the oxidative stress produces alterations in the production of adipokines, cytokines secreted by the adipose tissues. The abnormality in the transport of lipoprotein diminishes the catabolism of the very low density lipoprotein (VLDL) and increases the catabolism of the high density lipoprotein (HDL), which creates insulin resistance. This process is associated with a lower concentration of adiponectin that in turn regulates the catabolism of VLDL and HDL; consequently increasing the flow of fatty acids from the adipose tissue to the liver and muscles. The proinflammatory cytokines, among them tumor necrosis factor alpha (TNF-alpha), are of great importance in MS regulating different processes and molecules such as PAI-1. PAI-1 is controlled by the group of transcription factors peroxisome proliferator-activated receptor (PPAR), especially by PPAR gamma and alpha ligands. In summary, MS includes multiple alterations related to insulin resistance at several levels: hepatic, muscular, adipose and vascular tissue (endothelium). The exact mechanism that underlies the relationship between MS and CVD are not sufficiently known yet; pathogenic explanations are lacking for the mechanisms relating metabolic factors to insulin resistance and the association with the development of atherosclerosis and thrombosis. MS alterations and the main aspects related to homeostasis alterations are examined in this report.
C1 Univ Talca, Dept Clin Biochem & Immunohematol, Fac Hlth Sci, Talca, Chile.
   Univ Barcelona, Dept Bioquim & Biol Mol, Fac Biol, Barcelona, Spain.
C3 Universidad de Talca; University of Barcelona
RP Palomo, I (corresponding author), Univ Talca, Dept Clin Biochem & Immunohematol, Fac Hlth Sci, Mailbox 747, Talca, Chile.
EM ipalomo@utalca.cl
RI Alarcon, Marcelo/I-5016-2018; Palomo, Iván/I-4321-2018; Moore-Carrasco,
   Rodrigo/AAK-3349-2020; Argiles, Josep/L-5741-2014
OI alarcon, marcelo/0000-0001-7596-5382; Palomo, Ivan/0000-0002-9618-8778;
   Moore-Carrasco, Rodrigo/0000-0003-4870-9660; Argiles, Josep
   M./0000-0003-4683-5428
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NR 104
TC 71
Z9 76
U1 0
U2 3
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1107-3756
EI 1791-244X
J9 INT J MOL MED
JI Int. J. Mol. Med.
PD NOV
PY 2006
VL 18
IS 5
BP 969
EP 974
PG 6
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 097WE
UT WOS:000241479300022
PM 17016629
DA 2025-06-11
ER

PT J
AU Das, UN
AF Das, Undurti N.
TI Cytokines, angiogenic, and antiangiogenic factors and bioactive lipids
   in preeclampsia
SO NUTRITION
LA English
DT Review
DE Preeclampsia; Lipoxins; Oxidative stress; 2-Methoxyestradiol;
   Polyunsaturated fatty acids; Vascular endothelial growth factor;
   Endoglin; Soluble fms-like tyrosine kinase 1
ID ENDOTHELIAL GROWTH-FACTOR; NITRIC-OXIDE SYNTHASE; POLYUNSATURATED
   FATTY-ACIDS; TRIGGERED-LIPOXIN A(4); ANGIOTENSIN-ALDOSTERONE SYSTEM;
   CATECHOL-O-METHYLTRANSFERASE; PRO-INFLAMMATORY CYTOKINES;
   CONGESTIVE-HEART-FAILURE; METABOLIC SYNDROME-X; OXIDATIVE STRESS
AB Preeclampsia is a low-grade systemic inflammatory condition in which oxidative stress and endothelial dysfunction occurs. Plasma levels of soluble receptor for vascular endothelial growth factor (VEGFR)-1, also known as sFlt1 (soluble fms-like tyrosine kinase 1), an antiangiogenic factor have been reported to be elevated in preeclampsia. It was reported that pregnant mice deficient in catechol-O-methyltransferase (COMT) activity show a preeclampsia-like phenotype due to a deficiency or absence of 2-methoxyoestradiol (2-ME), a natural metabolite of estradiol that is elevated during the third trimester of normal human pregnancy. Additionally, autoantibodies (AT1-AAs) that bind and activate the angiotensin II receptor type 1 a (AT1 receptor) also have a role in preeclampsia. None of these abnormalities are consistently seen in all the patients with preeclampsia and some of them are not specific to pregnancy. Preeclampsia could occur due to an imbalance between pro- and antiangiogenic factors. VEGF, an angiogenic factor, is necessary for the transport of polyunsaturated fatty acids (PUFAs) to endothelial cells. Hence reduced VEGF levels decrease the availability of PUFAs to endothelial cells. This leads to a decrease in the formation of anti-inflammatory and angiogenic factors: lipoxins, resolvins, protectins, and maresins from PUFAs. Lipoxins, resolvins, protectins, maresins, and PUFAs suppress insulin resistance; activation of leukocytes, platelets, and macrophages; production of interleukin-6 and tumor necrosis factor-a; and oxidative stress and endothelial dysfunction; and enhance production of prostacyclin and nitric oxide (NO). Estrogen enhances the formation of lipoxin A(4) and NO. PUFAs also augment the production of NO and inhibit the activity of angiotensin-converting enzyme and antagonize the actions of angiotensin II. Thus, PUFAs can prevent activation of angiotensin II receptor type 1 a (AT1 receptor). Patients with preeclampsia have decreased plasma phospholipid concentrations of arachidonic acid (AA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA), the precursors of lipoxins (from AA), resolvins (from EPA and DHA), and protectins (from DHA) and prostaglandin E-1 (PGE(1) from DGLA: dihomo-gamma-linolenic acid) and prostacyclin (PGI(2) derived from AA). Based on these evidences, it is proposed that preeclampsia may occur due to deficiency of PUFAs and their anti-inflammatory products: lipoxins, resolvins, protectins, and maresins. (C) 2015 Elsevier Inc. All rights reserved.
C1 [Das, Undurti N.] UND Life Sci, Federal Way, WA 98003 USA.
   [Das, Undurti N.] GVP Hosp & BioSci Res Ctr, Dept Med, Visakhapatnam, Andhra Pradesh, India.
RP Das, UN (corresponding author), UND Life Sci, Federal Way, WA 98003 USA.
EM undurti@hotmail.com
RI Das, Undurti/A-7918-2009
FU Department of Biotechnology, New Delhi; Department of Science and
   Technology under Intensification of Research in High Priority Areas
   (IRPHA) [IR/SO/LU/03/2008/1]; Defence Research and Development
   Organisation, New Delhi [TC/2519/INM - 03/2011/CARS, INM-311]
FX The author is in receipt of Ramalingaswami Fellowship of the Department
   of Biotechnology, New Delhi during the tenure of this study. This work
   was supported by grants from the Department of Science and Technology
   (No. IR/SO/LU/03/2008/1) under Intensification of Research in High
   Priority Areas (IRPHA), and Defence Research and Development
   Organisation, New Delhi {(TC/2519/INM - 03/2011/CARS) under R&D Project
   INM-311) to the author.
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Z9 43
U1 0
U2 29
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0899-9007
EI 1873-1244
J9 NUTRITION
JI Nutrition
PD SEP
PY 2015
VL 31
IS 9
BP 1083
EP 1095
DI 10.1016/j.nut.2015.03.013
PG 13
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA CO8CQ
UT WOS:000359393000003
PM 26233865
DA 2025-06-11
ER

PT J
AU Stepaniuk, A
   Baran, A
   Flisiak, I
AF Stepaniuk, A.
   Baran, A.
   Flisiak, I.
TI Kynurenine Pathway in Psoriasis-a Promising Link?
SO DERMATOLOGY AND THERAPY
LA English
DT Review
DE Kynurenine; Kynurenine pathway; Psoriasis; Quinolinic acid
ID RISK
AB Psoriasis is a common dermatosis which affects the patient's skin and general well-being because of its link to diseases such as depression, kidney disease and metabolic syndrome. Pathogenesis remains unknown; however, genetic, environmental and immunological factors seem to play a role in the development of the disease. Due to a lack of complete understanding of the psoriasis pathology, effective treatment is yet to be developed. The kynurenine pathway is one of the ways amino acid tryptophan is metabolised. In comorbidities typical for psoriasis such as chronic kidney disease, depression and atherosclerotic alterations in the activation of the kynurenine pathway were observed, which were mainly characterised by higher activity compared to that in healthy individuals. However, the kynurenine pathway has not been thoroughly studied among patients with psoriasis even though increased levels of l-kynurenine, one of the enzymes in the kynurenine pathway, were found in psoriatic skin lesions. Given the unknown pathogenesis of the disease, this finding seems to be a potential new field of study and shows a possible link between psoriasis and its comorbidities that could also lead to novel effective treatment for this chronic condition.
C1 [Stepaniuk, A.; Baran, A.; Flisiak, I.] Med Univ Bialystok, Dept Dermatol & Venerol, Zurawia 14, PL-15540 Bialystok, Poland.
C3 Medical University of Bialystok
RP Stepaniuk, A (corresponding author), Med Univ Bialystok, Dept Dermatol & Venerol, Zurawia 14, PL-15540 Bialystok, Poland.
EM stepaniukanna@gmail.com
RI BARAN, ALPER/JCO-3007-2023; Flisiak, Iwona/R-5874-2018
OI Stepaniuk, Anna/0000-0003-1414-4569
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NR 50
TC 5
Z9 5
U1 2
U2 15
PU ADIS INT LTD
PI NORTHCOTE
PA 5 THE WAREHOUSE WAY, NORTHCOTE 0627, AUCKLAND, NEW ZEALAND
SN 2193-8210
EI 2190-9172
J9 DERMATOLOGY THER
JI Dermatol. Ther.
PD AUG
PY 2023
VL 13
IS 8
BP 1617
EP 1627
DI 10.1007/s13555-023-00958-4
EA JUN 2023
PG 11
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA M5NU5
UT WOS:001007893900001
PM 37326759
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Muraishi, M
   Shibayama, K
   Noguchi, M
   Watanabe, H
   Obunai, K
AF Muraishi, Makio
   Shibayama, Kentaro
   Noguchi, Masahiko
   Watanabe, Hiroyuki
   Obunai, Kotaro
TI Significance of intravascular ultrasound and exercise stress
   echocardiography in diagnosis of exercise-induced vasospastic angina at
   the site of moderate stenosis
SO JOURNAL OF MEDICAL ULTRASONICS
LA English
DT Article
DE Vasospastic angina; Intracoronary imaging; Stress echocardiography
ID CORONARY ARTERIAL SPASM; VARIANT ANGINA
AB Recently, exercise-induced spastic coronary artery occlusion at the site of moderate stenosis, which Prinzmetal's angina or cardiac syndrome X does not cover, was reported. Multi-modality imaging is important for the diagnosis of coronary artery disease with a complex ischemic mechanism. However, the previous report did not include findings from intracoronary imaging at the site of moderate coronary stenosis. We report a case of exercise-induced vasospastic angina at the site of moderate stenosis, where multi-modality imaging, including exercise stress echocardiography and intravascular ultrasound, was utilized to make a definitive diagnosis and investigate underlying causes.
C1 [Muraishi, Makio; Shibayama, Kentaro; Noguchi, Masahiko; Watanabe, Hiroyuki; Obunai, Kotaro] Tokyo Bay Urayasu Ichikawa Med Ctr, Dept Cardiol, 3-4-32 Todaijima, Chiba 2790001, Japan.
RP Shibayama, K (corresponding author), Tokyo Bay Urayasu Ichikawa Med Ctr, Dept Cardiol, 3-4-32 Todaijima, Chiba 2790001, Japan.
EM shibao_k@hotmail.com
RI Noguchi, Masahiko/JZT-2712-2024
OI Noguchi, Masahiko/0000-0003-4501-3449
CR ROBERTSON RM, 1982, CIRCULATION, V65, P281, DOI 10.1161/01.CIR.65.2.281
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   Yilmaz A, 2010, CIRCULATION, V122, pE570, DOI 10.1161/CIRCULATIONAHA.110.984823
NR 4
TC 0
Z9 0
U1 1
U2 2
PU SPRINGER JAPAN KK
PI TOKYO
PA CHIYODA FIRST BLDG EAST, 3-8-1 NISHI-KANDA, CHIYODA-KU, TOKYO, 101-0065,
   JAPAN
SN 1346-4523
EI 1613-2254
J9 J MED ULTRASON
JI J. Med. Ultrason.
PD APR
PY 2018
VL 45
IS 2
BP 315
EP 317
DI 10.1007/s10396-017-0815-4
PG 3
WC Radiology, Nuclear Medicine & Medical Imaging
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Radiology, Nuclear Medicine & Medical Imaging
GA GA0DN
UT WOS:000427983200015
PM 28819899
DA 2025-06-11
ER

PT J
AU Yamagishi, S
   Nakamura, K
   Inoue, H
AF Yamagishi, S
   Nakamura, K
   Inoue, H
TI Acarbose is a promising therapeutic strategy for the treatment of
   patients with nonalcoholic steatohepatitis (NASH)
SO MEDICAL HYPOTHESES
LA English
DT Article
ID FATTY LIVER-DISEASE; CARDIOVASCULAR-DISEASE; OXIDATIVE STRESS;
   PREVENTION; PREDICTORS; FIBROSIS; RISK
AB The metabolic syndrome is strongly associated with insulin resistance and has been recognized as a cluster of risk factors for cardiovascular diseases such as visceral obesity, hypertension, and diabetes. There is a growing body of evidence to show that nonalcoholic steatohepatitis (NASH) is the hepatic manifestation of insulin resistant patients with the metabolic syndrome. Indeed, insulin resistance increases adipocyte lipolysis and subsequently elevates circulating free fatty acids, thus stimulating the accumulation of fatty acids in the liver (hepatic steatosis). Fatty acids elicit reactive oxygen species generation, thereby promoting disease progression to NASH by both lipid peroxidation and inflammatory cytokine production. Postprandial hyperglycemia, one of the characteristic features of insulin resistance, also induces oxidative stress generation, being involved in dysfunction of pancreatic beta cells and vascular wall cells in the metabolic syndrome. Recently, STOP-NIDDM trial revealed that acarbose (Glucobay((R))), an alpha-glucosidase inhibitor, improved postprandial hyperglycemia and subsequently reduced the risk of development of type 2 diabetes and newly diagnosed hypertension in patients with impaired glucose tolerance. In this study, acarbose treatment was also found to reduce body mass index and waist circumference in these patients. Furthermore, a meta-analysis of seven tong-term studies has also shown that intervention with acarbose improved triglyceride Levels, body weight and systolic blood pressure and subsequently prevented myocardial infarction in type 2 diabetic patients. Since acarbose improves postprandial hyperglycemia by delaying the release of glucose from complex carbohydrates in the absence of an increase in insulin secretion, the beneficial aspects of acarbose could be ascribed to improvement of insulin sensitivity in these patients. Given the pathological link between NASH and insulin resistance, we would like to hypothesize here that acarbose may become a promising therapeutic strategy for the treatment of patients with NASH. Does acarbose treatment improve steatohepatitis histologically? Is the extent of histological improvement by acarbose parallel to that of insulin sensitivity in these patients? Large clinical trials will provide us with more definite information whether acarbose treatment can improve insulin sensitivity and resultantly reduce the risk of progression of liver diseases in patients with NASH. (c) 2005 Elsevier Ltd. All rights reserved.
C1 Kurume Univ, Sch Med, Dept Med, Kurume, Fukuoka 8300011, Japan.
   Kurume Univ, Sch Med, Radioisotope Inst Basic & Clin Med, Kurume, Fukuoka 8300011, Japan.
C3 Kurume University; Kurume University
RP Kurume Univ, Sch Med, Dept Med, 67 Asahi Machi, Kurume, Fukuoka 8300011, Japan.
EM shoichi@med.kurume-u.ac.jp
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NR 22
TC 12
Z9 13
U1 0
U2 10
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0306-9877
EI 1532-2777
J9 MED HYPOTHESES
JI Med. Hypotheses
PY 2005
VL 65
IS 2
BP 377
EP 379
DI 10.1016/j.mehy.2005.01.032
PG 3
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 935YI
UT WOS:000229818900029
PM 15922116
DA 2025-06-11
ER

PT J
AU Rabelo, F
   Stefano, JT
   Cavaleiro, AM
   Lima, RVC
   Mazo, DD
   Carrilho, FJ
   Correa-Giannella, ML
   Oliveira, CP
AF Rabelo, Fabiola
   Stefano, Jose Tadeu
   Cavaleiro, Ana Mercedes
   Costa Lima, Rodrigo Vieira
   de Campos Mazo, DanielFerraz
   Carrilho, Flair Jose
   Correa-Giannella, Maria Lucia
   Oliveira, Claudia P.
TI Association between the CYBA and NOX4 genes of NADPH oxidase and its
   relationship with metabolic syndrome in non-alcoholic fatty liver
   disease in Brazilian population
SO HEPATOBILIARY & PANCREATIC DISEASES INTERNATIONAL
LA English
DT Article
DE Non-alcoholic fatty liver disease; Nonalcoholic steatohepatitis; Genetic
   polymorphism; Metabolic syndrome
ID GENOME-WIDE ASSOCIATION; OXIDATIVE STRESS; POLYMORPHISMS;
   STEATOHEPATITIS; VARIANT; NEPHROPATHY; DIAGNOSIS; FIBROSIS
AB Background: Oxidative stress has been implicated in the progression of severe forms of non-alcoholic fatty liver disease (NAFLD). NADPH oxidase produces reactive oxygen species. In the present study, we investigated for the first time two single nucleotide polymorphisms (SNPs) in the regulatory region of genes encoding NADPH oxidase 4 (NOX4) and p22phox (CYBA) in NAFLD.
   Methods: A total of 207 biopsy-proven NAFLD patients [simple steatosis (n =27); nonalcoholic steatohepatitis (NASH) (n =180)] were evaluated. Genomic DNA was extracted from peripheral blood cells, and polymorphisms in CYBA (unregistered) and NOX4 (rs3017887) were determined by direct sequencing of PCR.
   Results: Associations of CYBA-675 T/A with high-density lipoprotein (HDL) (TT vs TA vs AA; P <0.01) and triglycerides (TGL) (TT vs XA; P < 0.01) were observed only in NASH patients. For polymorphisms in the NOX4 gene, NOX4 (rs3017887) CA + AA genotypes was significant associated with alanine aminotransferase (ALT) (CA + AA vs CC; P=0.02). However, there was no association of SNPs in the CYBA and NOX4 genes encoding the NADPH oxidase system proteins and the presence of NASH. Regarding the clinical results, it was observed that the most advanced degrees of fibrosis occurred in patients diagnosed with type 2 diabetes mellitus (66.9% vs 37.5%, P < 0.01) and those who were more obese (32.2 vs 29.0 kg/m(2), P < 0.01). In addition, serum glucose and insulin levels increased significantly in the presence of NASH.
   Conclusions: There were associations between the presence of the allele A in the NOX4 SNP and a higher concentration of ALT in the NAFLD population; between the presence of the AA genotype in the polymorphism of the CYBA-675 T/A CYBA gene and a higher level of TGL and lower HDL in NASH patients. The presence of metabolic syndrome was associated with advanced degrees of fibrosis in NAFLD patients. (C) 2018 First Affiliated Hospital, Zhejiang University School of Medicine in China. Published by Elsevier B.V. All rights reserved.
C1 [Rabelo, Fabiola; Costa Lima, Rodrigo Vieira; Carrilho, Flair Jose; Oliveira, Claudia P.] Univ Sao Paulo, Fac Med FMUSP, Dept Gastroenterol, Sao Paulo, SP, Brazil.
   [Rabelo, Fabiola; Stefano, Jose Tadeu; Costa Lima, Rodrigo Vieira; de Campos Mazo, DanielFerraz; Carrilho, Flair Jose; Oliveira, Claudia P.] Univ Sao Paulo, Fac Med, LIM07, Hosp Clin HCFMUSP,Dept Gastroenterol, Sao Paulo, SP, Brazil.
   [Cavaleiro, Ana Mercedes; Correa-Giannella, Maria Lucia] Univ Sao Paulo, Fac Med, Hosp Clin HCFMUSP LIM07, Lab Carboidratos & Radioimunensaio,LIM18, Sao Paulo, Brazil.
   [Correa-Giannella, Maria Lucia] Univ Nove Julho UNINOVE, Programa Posgrad Med, Sao Paulo, Brazil.
C3 Universidade de Sao Paulo; Universidade de Sao Paulo; Universidade de
   Sao Paulo; Universidade Nove de Julho
RP Oliveira, CP (corresponding author), Univ Sao Paulo, Fac Med FMUSP, Dept Gastroenterol, Sao Paulo, SP, Brazil.; Oliveira, CP (corresponding author), Univ Sao Paulo, Fac Med, LIM07, Hosp Clin HCFMUSP,Dept Gastroenterol, Sao Paulo, SP, Brazil.
EM cpm@usp.br
RI Carrilho, Flair/I-3046-2012; Correa-Giannella, Maria Lúcia/N-3834-2019;
   STEFANO, JOSE TADEU/AGR-5605-2022; Oliveira, Claudia/D-1216-2014; Mazo,
   Daniel/D-5631-2015
OI Carrilho, Flair Jose/0000-0002-7682-3105; Mazo,
   Daniel/0000-0002-2164-2630; P Oliveira, Claudia/0000-0002-2848-417X;
   Correa-Giannella, Maria Lucia/0000-0003-3655-4446
FU Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
   [Convenio PROAP 190/2014]
FX This study was supported by the grant from Coordenacao de
   Aperfeicoamento de Pessoal de Nivel Superior (CAPES) Grant no. Convenio
   PROAP 190/2014.
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NR 32
TC 16
Z9 17
U1 0
U2 2
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1499-3872
EI 2352-9377
J9 HEPATOB PANCREAT DIS
JI Hepatob. Pancreatic. Dis. Int.
PD AUG
PY 2018
VL 17
IS 4
BP 330
EP 335
DI 10.1016/j.hbpd.2018.06.005
PG 6
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA GS0OC
UT WOS:000443199800008
PM 30087027
DA 2025-06-11
ER

PT J
AU Boutayeb, A
   Boutayeb, S
   Boutayeb, W
AF Boutayeb, Abdesslam
   Boutayeb, Saber
   Boutayeb, Wiam
TI Multi-morbidity of non communicable diseases and equity in WHO Eastern
   Mediterranean countries
SO INTERNATIONAL JOURNAL FOR EQUITY IN HEALTH
LA English
DT Article
ID NONCOMMUNICABLE DISEASES; DEPRESSIVE-DISORDERS; CO-MORBIDITIES;
   PREVALENCE; ANXIETY; COMORBIDITY; HEALTH; BURDEN; ASSOCIATION; PATTERNS
AB Introduction: Non communicable diseases are the biggest cause of death worldwide. Beside mortality, these diseases also cause high rates of morbidity and disability. Their high prevalence is generally associated to multi-morbidity. Because they need costly prolonged treatment and care, non communicable diseases have social and economical consequences that affect individuals, households and the whole society. They raise the equity problem between and within countries.
   Methods and limitations: This annotated bibliography is a systematic review on multimorbidy of non communicable diseases and health equity in WHO Eastern Mediterranean countries. Medline/PubMed, EMBASE and other sources were used to get peer reviewed papers dealing with the review theme. The words/strings used for search and inclusion criteria were: multimorbidity, comorbidity, equity, non communicable diseases, chronic diseases, WHO Eastern Mediterranean and Arab countries.
   Bibliography with annotations: According to the inclusion criteria, 26 papers were included in the present review. Generally, lack or paucity of publications was encountered in themes like headache, cancer and respiratory diseases. Of the 26 contributions selected, twelve dealt with comorbidity of depression and mental disorders with other chronic diseases. Another set of 11 publications was devoted to multimorbidity of diabetes, cardiovascular diseases (CVDs), hypertension, metabolic syndrome and obesity. Considering association of multimorbidity and social determinants, this review shows that female gender, low income, low level of education, old age and unemployed/retired are the most exposed to multimorbidity. It should also be stressed that, geographically, no contribution was issued from North African countries.
   Non communicable diseases are one of the biggest challenges facing health decision makers in WHO Eastern Mediterranean countries where the multidimensional transition is boosting increases in multimorbidity of depression and mental diseases, cardiovascular diseases, diabetes, cancer and respiratory diseases among the whole population but with the highest burden among the least disadvantaged individuals or subpopulations. Health ministries in WHO Eastern Mediterranean countries should pay a particular attention to the association between equity and multimorbidity and opt for cost effective strategies based on early diagnosis and sensitisation for healthy diet, physical activity, no smoking and no alcohol.
C1 [Boutayeb, Abdesslam; Boutayeb, Wiam] Univ Mohamed Ier, LaMSD, Dept Math, Oujda, Morocco.
   [Boutayeb, Abdesslam; Boutayeb, Wiam] Univ Mohamed Ier, Fac Sci, URAC04, Oujda, Morocco.
   [Boutayeb, Saber] Natl Inst Oncol, Dept Med Oncol, Rabat, Morocco.
C3 Mohammed First University of Oujda; Mohammed First University of Oujda;
   Mohammed V University in Rabat; Ibn sina University Hospital Center of
   Rabat
RP Boutayeb, A (corresponding author), Univ Mohamed Ier, LaMSD, Dept Math, Oujda, Morocco.
EM x.boutayeb@menara.ma
OI boutayeb, saber/0000-0003-1642-9330; Boutayeb,
   Abdesslam/0000-0003-0579-4383
CR Abdul-Rahim HF, 2001, INT J OBESITY, V25, P1736, DOI 10.1038/sj.ijo.0801799
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   Alwakeel JS, 2009, SAUDI J KIDNEY DIS T, V20, P402
   [Anonymous], 2022, NONCOMMUNICABLE DIS
   [Anonymous], TANAFFOS
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   Boutayeb A, 2006, T ROY SOC TROP MED H, V100, P191, DOI 10.1016/j.trstmh.2005.07.021
   Boutayeb A., 2012, OPEN J EPIDEMIOLOGY, V2, P55
   Boutayeb Abdesslam, 2005, Int J Equity Health, V4, P2, DOI 10.1186/1475-9276-4-2
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   Commission on Social Determinants of health, 2008, CLOS GAP GEN HLTH EQ
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   International Diabetes Federation, 2011, IDF DIABETES ATLAS
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   Rithie CS, 2011, J ONCOLOGY PRACTICE, V7, P371
   Schwab K., 2010, GLOBAL RISKS 2010 A
   Shah NM, 2010, MED PRIN PRACT, V19, P105, DOI 10.1159/000273069
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   Shiri R, 2006, AM J ADDICTION, V15, P468, DOI 10.1080/10550490601000421
   The WHO, 2011, Global Atlas on Cardiovascular Disease Prevention and Control, P2
   UNDP, HUM DEV IND IN ADJ H
   Waheed Abdul, 2006, JPMA Journal of the Pakistan Medical Association, V56, P243
   WHO, 2010, WORLD MALARIA REPORT 2010, P1
   World Health Organization, 2011, CLOS GAP POL PRACT S
   Yekta Z., 2010, Eastern Mediterranean Health Journal, V16, P286
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   Zindah Meyasser, 2008, Prev Chronic Dis, V5, pA17
NR 43
TC 88
Z9 100
U1 0
U2 24
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1475-9276
J9 INT J EQUITY HEALTH
JI Int. J. Equity Health
PD AUG 20
PY 2013
VL 12
AR 60
DI 10.1186/1475-9276-12-60
PG 13
WC Public, Environmental & Occupational Health
WE Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA 222NG
UT WOS:000324737300001
PM 23961989
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Slagter, SN
   van Vliet-Ostaptchouk, JV
   van Beek, AP
   Keers, JC
   Lutgers, HL
   van der Klauw, MM
   Wolffenbuttel, BHR
AF Slagter, Sandra N.
   van Vliet-Ostaptchouk, Jana V.
   van Beek, Andre P.
   Keers, Joost C.
   Lutgers, Helen L.
   van der Klauw, Melanie M.
   Wolffenbuttel, Bruce H. R.
TI Health-Related Quality of Life in Relation to Obesity Grade, Type 2
   Diabetes, Metabolic Syndrome and Inflammation
SO PLOS ONE
LA English
DT Article
ID C-REACTIVE PROTEIN; BODY-MASS INDEX; CHRONIC KIDNEY-DISEASE;
   FUNCTIONAL-CAPACITY; INDIVIDUALS; SF-36; MEN; ASSOCIATION; OVERWEIGHT;
   WEIGHT
AB Background
   Health-related quality of life (HR-QoL) may be compromised in obese individuals, depending on the presence of other complications. The aim of this study is to assess the effect of obesity-related conditions on HR-QoL. These conditions are i) grade of obesity with and without type 2 diabetes (T2D), ii) metabolic syndrome (MetS), and iii) level of inflammation.
   Methods
   From the Dutch LifeLines Cohort Study we included 13,686 obese individuals, aged 18-80 years. HR-QoL was measured with the RAND 36-Item Health Survey which encompasses eight health domains. We calculated the percentage of obese individuals with poor HR-QoL, i.e. those scoring below the domain and sex specific cut-off value derived from the normal weight population. Logistic regression analysis was used to calculate the probability of having poor domain scores according to the conditions under study.
   Results
   Higher grades of obesity and the additional presence of T2D were associated with lower HR-QoL, particularly in the domains physical functioning (men: odds ratios (ORs) 1.48-11.34, P<0.005, and women: ORs 1.66-5.05, P<0.001) and general health (men: ORs 1.44-3.07, P<0.005, and women: ORs 1.36-3.73, P<0.001). A higher percentage of obese individuals with MetS had a poor HR-QoL than those without MetS. Furthermore, we observed a linear trend between inflammation and the percentage of obese individuals with poor scores on the HR-QoL domains. Individuals with MetS were more likely to have poor scores in the domains general health, vitality, social functioning and role limitations due to emotional problems. Obese women with increased inflammation levels were more likely to have poor scores on all domains except role limitations due to emotional problems and mental health.
   Conclusions
   The impact of obesity on an individual's quality of life is enhanced by grade of obesity, T2D, MetS and inflammation and are mainly related to reduced physical health. The mental wellbeing is less often impaired.
C1 [Slagter, Sandra N.; van Vliet-Ostaptchouk, Jana V.; van Beek, Andre P.; Keers, Joost C.; Lutgers, Helen L.; van der Klauw, Melanie M.; Wolffenbuttel, Bruce H. R.] Univ Groningen, Univ Med Ctr Groningen, Dept Endocrinol, Groningen, Netherlands.
   [Keers, Joost C.] Martini Hosp, Van Swieten Res Inst, Groningen, Netherlands.
C3 University of Groningen; Martini Hospital
RP Wolffenbuttel, BHR (corresponding author), Univ Groningen, Univ Med Ctr Groningen, Dept Endocrinol, Groningen, Netherlands.
EM bwo@umcg.nl
RI Lutgers, Helen/MFK-2548-2025; van der Klauw, Melanie/A-2138-2014; van
   Beek, Andre/O-3753-2014
OI van Vliet-Ostaptchouk, Jana/0000-0002-7943-3153; van der Klauw,
   Melanie/0000-0001-7178-009X; van Beek, Andre/0000-0002-0335-8177;
   Wolffenbuttel, Bruce H.R./0000-0001-9262-6921
FU Netherlands Organization of Scientific Research (NWO)
   [175.010.2007.006]; Economic Structure Enhancing Fund (FES) of the Dutch
   government; Ministry of Economic Affairs; Ministry of Education, Culture
   and Science; Ministry for Health, Welfare and Sports; Northern
   Netherlands Collaboration of Provinces (SNN); Province of Groningen;
   University Medical Center Groningen; University of Groningen; Dutch
   Kidney Foundation; Dutch Diabetes Research Foundation; National
   Consortium for Healthy Ageing; European Union's Seventh Framework
   programme (FP7) through the BioSHaRE-EU (Biobank Standardisation and
   Harmonisation for Research Excellence in the European Union) [261433]
FX The LifeLines Cohort Study was supported by the Netherlands Organization
   of Scientific Research (NWO) [grant 175.010.2007.006]; the Economic
   Structure Enhancing Fund (FES) of the Dutch government; the Ministry of
   Economic Affairs; the Ministry of Education, Culture and Science; the
   Ministry for Health, Welfare and Sports; the Northern Netherlands
   Collaboration of Provinces (SNN); the Province of Groningen; University
   Medical Center Groningen; the University of Groningen; the Dutch Kidney
   Foundation; and the Dutch Diabetes Research Foundation. This work was
   supported by the National Consortium for Healthy Ageing, and the
   European Union's Seventh Framework programme (FP7/2007-2013) through the
   BioSHaRE-EU (Biobank Standardisation and Harmonisation for Research
   Excellence in the European Union) project, grant agreement 261433.
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NR 40
TC 64
Z9 70
U1 0
U2 9
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD OCT 16
PY 2015
VL 10
IS 10
AR e0140599
DI 10.1371/journal.pone.0140599
PG 17
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Science & Technology - Other Topics
GA CU0DF
UT WOS:000363185500071
PM 26474291
OA gold, Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Kaur, D
   Bucholc, M
   Finn, DP
   Todd, S
   Wong-Lin, K
   McClean, PL
AF Kaur, Daman
   Bucholc, Magda
   Finn, David P.
   Todd, Stephen
   Wong-Lin, Kongfatt
   McClean, Paula L.
TI Multi-time-point data preparation robustly reveals MCI and dementia risk
   factors
SO ALZHEIMER'S & DEMENTIA: DIAGNOSIS, ASSESSMENT & DISEASE MONITORING
LA English
DT Article
DE baseline; cardiometabolic risk factors; dementia progression;
   longitudinal data; mild cognitive impairment (MCI); multi-time-point
   data preparation; multivariate logistic regression; National Alzheimer's
   Coordinating Center data
ID MILD COGNITIVE IMPAIRMENT; DEPRESSIVE SYMPTOMS; INCIDENT DEMENTIA;
   ALZHEIMER-DISEASE; MEASUREMENT ERROR; HYPERTENSION; DECLINE; MIDLIFE;
   OLD; EPIDEMIOLOGY
AB Introduction: Conflicting results on dementia risk factors have been reported across studies. We hypothesize that variation in data preparation methods may partially contribute to this issue.
   Methods: We propose a comprehensive data preparation approach comparing individuals with stable diagnosis over time to those who progress to mild cognitive impairment (MCI)/dementia. This was compared to the often-used "baseline" analysis. Multivariate logistic regression was used to evaluate both methods.
   Results: The results obtained from sensitivity analyses were consistent with those from our multi-time-point data preparation approach, exhibiting its robustness. Compared to analysis using only baseline data, the number of significant risk factors identified in progression analyses was substantially lower. Additionally, we found that moderate depression increased healthy-to-MCI/dementia risk, while hypertension reduced MCI-to-dementia risk.
   Discussion: Overall, multi-time-point-based data preparation approaches may pave the way for a better understanding of dementia risk factors, and address some of the reproducibility issues in the field.
C1 [Kaur, Daman; McClean, Paula L.] Ulster Univ, Northern Ireland Ctr Stratified Med, Biomed Sci Res Inst, Clin Translat Res & Innovat Ctr C TRIC, Altnagelvin Hosp Site, Derry Londonderry, North Ireland.
   [Bucholc, Magda; Wong-Lin, Kongfatt] Ulster Univ, Intelligent Syst Res Ctr, Sch Comp Engn & Intelligent Syst, Derry Londonderry, North Ireland.
   [Finn, David P.] Natl Univ Ireland Galway, Pharmacol & Therapeut, Sch Med, Galway Neurosci Ctr, Univ Rd, Galway, Ireland.
   [Todd, Stephen] Western Hlth & Social Care Trust, Altnagelvin Area Hosp, Derry Londonderry, Ireland.
C3 Ulster University; Ulster University; Ollscoil na Gaillimhe-University
   of Galway
RP Kaur, D (corresponding author), Ulster Univ, Biomed Sci Res Inst, Northern Ireland Ctr Stratified Med, C TRIC, Altnagelvin Hosp Site, Derry Londonderry BT47 6SB, Ireland.
EM kaur-d1@ulster.ac.uk
RI Bucholc, Magda/ABF-9272-2020
OI Bucholc, Magda/0000-0002-8417-1602; Kaur, Daman
   Preet/0009-0004-2752-6843; McClean, Paula/0000-0002-3906-1172; Wong-Lin,
   KongFatt/0000-0001-8724-4398
FU European Union [IVA 5036]; Northern Ireland Functional Brain Mapping
   Project Facility - Northern Ireland [1303/101154803]; University of
   Ulster; Alzheimer's Research UK (ARUK) NI Pump Priming; Ulster
   University Research Challenge Fund; Dr George Moore Endowmentfor Data
   Science at Ulster University; COST Action Open Multiscale Systems
   Medicine (OpenMultiMed) - COST(European Cooperation in Science and
   Technology); NIA/NIH [U01 AG016976]; NIA [P30 AG019610, P30 AG013846,
   P50 AG008702, P50 AG025688, P50 AG047266, P30 AG010133, P50 AG005146,
   P50 AG005134, P50 AG016574, P50 AG005138, P30 AG008051, P30AG013854, P30
   AG008017, P30 AG010161, P50 AG047366, P30 AG010129]; The NIA [P50
   AG016573, P50 AG005131, P50 AG023501, P30 AG035982, P30 AG028383,
   P30AG053760, P30 AG010124, P50AG005133, P50AG005142, P30 AG012300, P30
   AG049638, P50 AG005136, P50 AG033514, P50 AG005681, P50 AG047270]
FX This project was supported by the European Union's INTERREG VA
   Programme, managed by the Special EU Programmes Body (SEUPB [Centre for
   Personalised Medicine, IVA 5036]), with additional support by
   theNorthern Ireland Functional Brain Mapping Project Facility
   (1303/101154803), funded by invest Northern Ireland and the University
   of Ulster (KongFatt Wong-Lin), Alzheimer's Research UK (ARUK) NI Pump
   Priming (Magda Bucholc, Stephen Todd, KongFattWong-Lin, Paula L.
   McClean), Ulster University Research Challenge Fund (Magda Bucholc,
   Stephen Todd, KongFatt Wong-Lin), the Dr George Moore Endowmentfor Data
   Science atUlsterUniversity (MagdaBucholc), and the COST Action
   OpenMultiscale Systems Medicine (OpenMultiMed) supported
   byCOST(EuropeanCooperation in Science and Technology; KongFatt
   Wong-Lin). The views and opinions expressed in this article do not
   necessarily reflect those of the European Commission or the SEUPB. The
   NACC database is funded by NIA/NIH Grant U01 AG016976. NACC data are
   contributed by the NIA-funded ADCs: P30 AG019610 (PI Eric Reiman, MD),
   P30 AG013846 (PI Neil Kowall, MD), P50 AG008702 (PI Scott Small, MD),
   P50 AG025688 (PI Allan Levey, MD, PhD), P50 AG047266 (PI Todd Golde, MD,
   PhD), P30 AG010133 (PI Andrew Saykin, PsyD), P50 AG005146 (PI Marilyn
   Albert, PhD), P50 AG005134 (PI Bradley Hyman, MD, PhD), P50 AG016574 (PI
   Ronald Petersen, MD, PhD), P50 AG005138 (PIMary Sano, PhD), P30 AG008051
   (PI Thomas Wisniewski, MD), P30AG013854 (PIM. Marsel Mesulam, MD), P30
   AG008017 (PI Jeffrey Kaye, MD), P30 AG010161 (PI David Bennett, MD), P50
   AG047366 (PI Victor Henderson, MD, MS), P30 AG010129 (PI Charles
   DeCarli, MD), P50 AG016573 (PI Frank LaFerla, PhD), P50 AG005131 (PI
   James Brewer, MD, PhD), P50 AG023501 (PI Bruce Miller, MD), P30 AG035982
   (PI Russell Swerdlow, MD), P30 AG028383 (PI Linda Van Eldik, PhD),
   P30AG053760 (PI Henry Paulson, MD, PhD), P30 AG010124 (PI John
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NR 50
TC 4
Z9 4
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
EI 2352-8729
J9 ALZH DEMENT-DADM
JI Alzheimers Dement.-Diagn. Assess. Dis. Monit.
PY 2020
VL 12
IS 1
AR e12116
DI 10.1002/dad2.12116
PG 13
WC Clinical Neurology; Neurosciences
WE Emerging Sources Citation Index (ESCI)
SC Neurosciences & Neurology
GA WG7VU
UT WOS:000707203600112
PM 33088897
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Aghamohammadzadeh, R
   Withers, S
   Lynch, F
   Greenstein, A
   Malik, R
   Heagerty, A
AF Aghamohammadzadeh, Reza
   Withers, Sarah
   Lynch, Fiona
   Greenstein, Adam
   Malik, R.
   Heagerty, Anthony
TI Perivascular adipose tissue from human systemic and coronary vessels:
   the emergence of a new pharmacotherapeutic target
SO BRITISH JOURNAL OF PHARMACOLOGY
LA English
DT Review
DE perivascular adipose tissue; PVAT; adipocytes; adipokines; obesity;
   metabolic syndrome; adiponectin; leptin; epicardial adipose tissue;
   coronary vessels
ID RENIN-ANGIOTENSIN SYSTEM; SPONTANEOUSLY HYPERTENSIVE-RATS;
   CONVERTING-ENZYME INHIBITION; VASCULAR ENDOTHELIAL-CELLS; NITRIC-OXIDE
   SYNTHASE; INSULIN-RESISTANCE; METABOLIC-SYNDROME; ADIPONECTIN RECEPTORS;
   OXIDATIVE STRESS; ARTERY-DISEASE
AB Fat cells or adipocytes are distributed ubiquitously throughout the body and are often regarded purely as energy stores. However, recently it has become clear that these adipocytes are engine rooms producing large numbers of metabolically active substances with both endocrine and paracrine actions. White adipocytes surround almost every blood vessel in the human body and are collectively termed perivascular adipose tissue (PVAT). It is now well recognized that PVAT not only provides mechanical support for any blood vessels it invests, but also secretes vasoactive and metabolically essential cytokines known as adipokines, which regulate vascular function. The emergence of obesity as a major challenge to our healthcare systems has contributed to the growing interest in adipocyte dysfunction with a view to discovering new pharmacotherapeutic agents to help rescue compromised PVAT function. Very few PVAT studies have been carried out on human tissue. This review will discuss these and the hypotheses generated from such research, as well as highlight the most significant and clinically relevant animal studies showing the most pharmacological promise.
C1 [Heagerty, Anthony] Univ Manchester, Cardiovasc Res Grp, Div Cardiovasc & Endocrine Sci, Core Technol Facil Floor 3, Manchester M13 9NT, Lancs, England.
C3 University of Manchester
RP Heagerty, A (corresponding author), Univ Manchester, Cardiovasc Res Grp, Div Cardiovasc & Endocrine Sci, Core Technol Facil Floor 3, 46 Grafton St, Manchester M13 9NT, Lancs, England.
EM tony.heagerty@manchester.ac.uk
RI Malik, Rayaz/H-9231-2019
OI Heagerty, Anthony/0000-0002-9043-2119; Aghamohammadzadeh,
   Reza/0000-0002-6058-9078; Malik, Rayaz/0000-0002-7188-8903; Withers,
   Sarah/0000-0002-7021-881X; Greenstein, Adam/0000-0002-5274-4189
FU Manchester Wellcome Trust
FX Our group is supported by the Manchester Wellcome Trust Clinical
   Research Facility and Dr Aghamohammadzadeh is a British Heart Foundation
   and NIHR Manchester Biomedical Research Centre Clinical Research Fellow.
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EP 682
DI 10.1111/j.1476-5381.2011.01479.x
PG 13
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 874JS
UT WOS:000298953100011
PM 21564083
OA Green Published
DA 2025-06-11
ER

PT J
AU Berardo, C
   Di Pasqua, LG
   Cagna, M
   Richelmi, P
   Vairetti, M
   Ferrigno, A
AF Berardo, Clarissa
   Di Pasqua, Laura Giuseppina
   Cagna, Marta
   Richelmi, Plinio
   Vairetti, Mariapia
   Ferrigno, Andrea
TI Nonalcoholic Fatty Liver Disease and Non-Alcoholic Steatohepatitis:
   Current Issues and Future Perspectives in Preclinical and Clinical
   Research
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE non-alcoholic fatty liver disease; metabolic syndrome; steatohepatitis;
   hepatocellular carcinoma; steatosis
ID ACTIVATED RECEPTOR-ALPHA; HEPATIC STELLATE CELLS; ASYMMETRIC
   DIMETHYLARGININE ADMA; DE-NOVO LIPOGENESIS; IN-VITRO MODEL; PPAR-ALPHA;
   INSULIN-RESISTANCE; CHOLINE-DEFICIENT; OXIDATIVE STRESS;
   LIPID-METABOLISM
AB Nonalcoholic fatty liver disease (NAFLD) is a continuum of liver abnormalities often starting as simple steatosis and to potentially progress into nonalcoholic steatohepatitis (NASH), fibrosis, cirrhosis and hepatocellular carcinoma. Because of its increasing prevalence, NAFLD is becoming a major public health concern, in parallel with a worldwide increase in the recurrence rate of diabetes and metabolic syndrome. It has been estimated that NASH cirrhosis may surpass viral hepatitis C and become the leading indication for liver transplantation in the next decades. The broadening of the knowledge about NASH pathogenesis and progression is of pivotal importance for the discovery of new targeted and more effective therapies; aim of this review is to offer a comprehensive and updated overview on NAFLD and NASH pathogenesis, the most recommended treatments, drugs under development and new drug targets. The most relevant in vitro and in vivo models of NAFLD and NASH will be also reviewed, as well as the main molecular pathways involved in NAFLD and NASH development.
C1 [Berardo, Clarissa; Di Pasqua, Laura Giuseppina; Cagna, Marta; Richelmi, Plinio; Vairetti, Mariapia; Ferrigno, Andrea] Univ Pavia, Unit Cellular & Mol Pharmacol & Toxicol, Dept Internal Med & Therapeut, I-27100 Pavia, Italy.
C3 University of Pavia
RP Di Pasqua, LG; Ferrigno, A (corresponding author), Univ Pavia, Unit Cellular & Mol Pharmacol & Toxicol, Dept Internal Med & Therapeut, I-27100 Pavia, Italy.
EM clarissa.berardo01@universitadipavia.it;
   lauragiuseppin.dipasqua01@universitadipavia.it;
   marta.cagna02@universitadipavia.it; plinio.richelmi@unipv.it;
   mariapia.vairetti@unipv.it; andrea.ferrigno@unipv.it
RI Cagna, Marta/AAD-4143-2021; Vairetti, Mariapia/AAM-1757-2020; Ferrigno,
   Andrea/J-2087-2019; Di Pasqua, Laura/Y-3987-2019; Berardo,
   Clarissa/U-7316-2019
OI Di Pasqua, Laura Giuseppina/0000-0003-0103-1493; Ferrigno,
   Andrea/0000-0003-2337-2897; Berardo, Clarissa/0000-0002-1257-5843;
   Vairetti, Mariapia/0000-0002-2464-6127
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NR 207
TC 48
Z9 51
U1 1
U2 19
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD DEC
PY 2020
VL 21
IS 24
AR 9646
DI 10.3390/ijms21249646
PG 29
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA PL1RZ
UT WOS:000602909200001
PM 33348908
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Dini, L
   Tacconi, S
   Carata, E
   Tata, AM
   Vergallo, C
   Panzarini, E
AF Dini, L.
   Tacconi, S.
   Carata, E.
   Tata, A. M.
   Vergallo, C.
   Panzarini, E.
TI Microvesicles and exosomes in metabolic diseases and inflammation
SO CYTOKINE & GROWTH FACTOR REVIEWS
LA English
DT Review
DE Metabolic disorders; Inflammation; Extracellular vesicles; M1
   macrophages; M2 macrophages
ID ADIPOSE-TISSUE MACROPHAGES; EXTRACELLULAR VESICLES; INSULIN-RESISTANCE;
   FATTY-ACIDS; ENDOTHELIAL-CELLS; SKELETAL-MUSCLE; DENDRITIC CELLS;
   OBESITY; INDUCE; EXPRESSION
AB Metabolic diseases are based on a dysregulated crosstalk between various cells such as adipocytes, hepatocytes and immune cells. Generally, hormones and metabolites mediate this crosstalk that becomes alterated in metabolic syndrome including obesity and diabetes. Recently, Extracellular Vesicles (EVs) are emerging as a novel way of cell-to-cell communication and represent an attractive strategy to transfer fundamental informations between the cells through the transport of proteins and nucleic acids. EVs, released in the extracellular space, circulate via the various body fluids and modulate the cellular responses following their interaction with the near and far target cells. Clinical and experimental data support their role as biomarkers and bioeffectors in several diseases includimg also the metabolic syndrome. Despite numerous studies on the role of macrophages in the development of metabolic diseases, to date, there are little informations about the influence of metabolic stress on the EVs produced by macrophages and about the role of the released vesicles in the organism. Here, we review current understanding about the role of EVs in metabolic diseases, mainly in inflammation status burst. This knowledge may play a relevant role in health monitoring, medical diagnosis and personalized medicine.
C1 [Dini, L.; Tata, A. M.] Sapienza Univ Rome, Dept Biol & Biotechnol C Darwin, Piazzale Aldo Moro 5, I-00185 Rome, Italy.
   [Dini, L.] CNR Nanotec, Lecce, Italy.
   [Tacconi, S.; Carata, E.; Panzarini, E.] Univ Salento, Dept Biol & Environm Sci & Technol DiSTeBA, Via Prov Le Lecce Monteroni, I-73100 Lecce, Italy.
   [Tata, A. M.] Sapienza Univ Rome, Res Ctr Neurobiol Daniel Bovet, Rome, Italy.
   [Vergallo, C.] Univ Chieti Pescara G dAnnunzio, Dept Pharm, Chieti, Italy.
C3 Sapienza University Rome; Consiglio Nazionale delle Ricerche (CNR);
   Istituto di Nanotecnologia (NANOTEC-CNR); University of Salento;
   Sapienza University Rome; G d'Annunzio University of Chieti-Pescara
RP Dini, L (corresponding author), Sapienza Univ Rome, Dept Biol & Biotechnol C Darwin, Piazzale Aldo Moro 5, I-00185 Rome, Italy.; Panzarini, E (corresponding author), Univ Salento, Dept Biol & Environm Sci & Technol DiSTeBA, Via Prov Le Lecce Monteroni, I-73100 Lecce, Italy.
EM luciana.dini@uniroma1.it; elisa.panzarini@unisalento.it
RI Tacconi, Stefano/JFJ-4278-2023; Vergallo, Cristian/J-4303-2019; CARATA,
   Elisabetta/J-9621-2016
OI CARATA, Elisabetta/0000-0002-3801-5457; Vergallo,
   Cristian/0000-0002-0264-4753
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NR 120
TC 56
Z9 60
U1 5
U2 29
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1359-6101
EI 1879-0305
J9 CYTOKINE GROWTH F R
JI Cytokine Growth Factor Rev.
PD FEB
PY 2020
VL 51
SI SI
BP 27
EP 39
DI 10.1016/j.cytogfr.2019.12.008
PG 13
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA KN0YO
UT WOS:000514566400005
PM 31917095
DA 2025-06-11
ER

PT J
AU Oresic, M
AF Oresic, Matej
TI Systems biology strategy to study lipotoxicity and the metabolic
   syndrome
SO BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
LA English
DT Review
DE Allostasis; Gene network; Lipid metabolism; Lipidomics; Metabolomics;
   Systems biology
ID MOLECULAR NETWORKS; OXIDATIVE STRESS; GENE-EXPRESSION; LIPIDOMICS;
   ALGORITHMS; RESPONSES; GENOMICS; OBESITY; SAMPLES; BRIDGE
AB Systems biology views and studies the biological systems in the context of complex interactions between their building blocks and processes. Given its multi-level complexity, metabolic syndrome (MetS) makes a strong case for adopting the systems biology approach. Despite many MetS traits being highly heritable, it is becoming evident that the genetic contribution to these traits is mediated via gene-gene and gene-environment interactions across several spatial and temporal scales, and that some of these traits such as lipotoxicity may even be a product of long-term dynamic changes of the underlying genetic and molecular networks. This presents several conceptual as well as methodological challenges and may demand a paradigm shift in how we study the undeniably strong genetic component of complex diseases such as MetS. The argument is made here that for adopting systems biology approaches to MetS an integrative framework is needed which glues the biological processes of MetS with specific physiological mechanisms and principles and that lipotoxicity is one such framework. The metabolic phenotypes, molecular and genetic networks can be modeled within the context of such integrative framework and the underlying physiology. (C) 2009 Elsevier B.V. All rights reserved.
C1 VTT Tech Res Ctr Finland, FIN-02044 Espoo, Vtt, Finland.
C3 VTT Technical Research Center Finland
RP Oresic, M (corresponding author), VTT Tech Res Ctr Finland, Tietotie 2,POB 1000, FIN-02044 Espoo, Vtt, Finland.
EM matej.oresic@vtt.fi
RI Oresic, Matej/K-7673-2016
OI Oresic, Matej/0000-0002-2856-9165
FU EU [FP7-KBBE-222639]; TORNADO [FP7-KBBE-222720]
FX This work was supported by the EU-funded projects ETHERPATHS
   (FP7-KBBE-222639, http://www.etherpaths.org/) and TORNADO
   (FP7-KBBE-222720, http://www.fp7tornado.eu/).
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PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1388-1981
EI 1879-2618
J9 BBA-MOL CELL BIOL L
JI Biochim. Biophys. Acta Mol. Cell Biol. Lipids
PD MAR
PY 2010
VL 1801
IS 3
SI SI
BP 235
EP 239
DI 10.1016/j.bbalip.2009.11.003
PG 5
WC Biochemistry & Molecular Biology; Biophysics; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Cell Biology
GA 568YT
UT WOS:000275563300006
PM 19944187
DA 2025-06-11
ER

PT J
AU Catar, RA
   Mueller, G
   Heidler, J
   Schmitz, G
   Bornstein, SR
   Morawietz, H
AF Catar, R. A.
   Mueller, G.
   Heidler, J.
   Schmitz, G.
   Bornstein, S. R.
   Morawietz, H.
TI Low-density lipoproteins induce the renin-angiotensin system and their
   receptors in human endothelial cells
SO HORMONE AND METABOLIC RESEARCH
LA English
DT Article
DE endothelial cells; low-density lipoprotein; oxLDL receptor;
   renin-angiotensin system
ID NF-KAPPA-B; UP-REGULATION; OXIDIZED-LDL; CONVERTING ENZYME;
   GENE-EXPRESSION; SHEAR-STRESS; OX-LDL; ATHEROSCLEROSIS; LOX-1;
   TOLL-LIKE-RECEPTOR-4
AB Increased levels of low-density lipoproteins are well-established risk factors of endothelial dysfunction and the metabolic syndrome. In this study, we evaluated the effect of native low-density lipoprotein (nLDL) and oxidized LDL (oxLDL) on the expression of genes of the renin-angiotensin system (angiotensin-converting enzyme, ACE; angiotensin 11 type I receptor, AT,) and their receptors (low-density lipoprotein receptor: LDLR; lectin-like oxLDL receptor: LOX-1; toll-like receptor 4: TLR4) in primary cultures of human umbilical vein endothelial cells. ACE and AT, expressions were significantly increased after stimulation with nLDL and oxLDL. OxLDL receptor LOX-1 showed a maximum induction after 7 hours. Increased LOX-1 protein expression in response to oxLDL could be blocked by a LOX-1 specific antibody. TLR4 expression was increased by nLDL and oxLDL as well. We conclude that LDL and oxLDL can activate the renin-angiotensin system and their receptors LDLR, LOX-1, and TLR4 in human endothelial cells. These data suggest a novel link between hypercholesterolemia and hypertension in patients with the metabolic syndrome.
RP Morawietz, H (corresponding author), Tech Univ Dresden, Carl Gustav Carus Med Sch, Med Clin & Policlin III, Dept Vasc Endothelium & Microcirculat, Fetscherstasse 74, D-01307 Dresden, Germany.
EM Henning.Morawietz@tu-dresden.de
RI Catar, Rusan/I-3948-2019; Mueller, Gregor/F-3911-2010; Heidler,
   Juliana/MTE-0484-2025
OI Muller, Gregor/0009-0000-9791-1991; Catar, Rusan/0000-0002-7000-7860
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NR 35
TC 46
Z9 51
U1 0
U2 8
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0018-5043
EI 1439-4286
J9 HORM METAB RES
JI Horm. Metab. Res.
PD NOV
PY 2007
VL 39
IS 11
BP 801
EP 805
DI 10.1055/s-2007-991158
PG 5
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 239VF
UT WOS:000251545700006
PM 17992634
DA 2025-06-11
ER

PT J
AU Omidkhoda, N
   Mahdiani, S
   Hayes, AW
   Karimi, G
AF Omidkhoda, Navid
   Mahdiani, Sina
   Hayes, A. Wallace
   Karimi, Gholamreza
TI Natural compounds against nonalcoholic fatty liver disease: A review on
   the involvement of the LKB1/AMPK signaling pathway
SO PHYTOTHERAPY RESEARCH
LA English
DT Review
DE AMPK; LKB1; NAFLD; NASH
ID EUTERPE-OLERACEA MART.; HEPATIC LIPID-ACCUMULATION; ACTIVATED
   PROTEIN-KINASE; GREEN TEA CATECHINS; CYNANCHUM-WILFORDII; COROSOLIC
   ACID; ZANTHOXYLUM-AILANTHOIDES; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   OXIDATIVE STRESS
AB Although various therapeutic approaches are used to manage nonalcoholic fatty liver disease (NAFLD), the best approach to NAFLD management is unclear. NAFLD is a liver disorder associated with obesity, metabolic syndrome, and diabetes mellitus. NAFLD progression can lead to cirrhosis and end-stage liver disease. Hepatic kinase B1 (LKB1) is an upstream kinase of 50-adenosine monophosphate-activated protein kinase (AMPK), a crucial regulator in hepatic lipid metabolism. Activation of LKB1/AMPK inhibits fatty acid synthesis, increases mitochondrial beta-oxidation, decreases the expression of genes encoding lipogenic enzymes, improves nonalcoholic steatohepatitis, and suppresses NAFLD progression. One potential opening for new and safe chemicals that can tackle the NAFLD pathogenesis through the LKB1-AMPK pathway includes natural bioactive compounds. Accordingly, we summarized in vitro and in vivo studies regarding the effect of natural bioactive compounds such as a few members of the polyphenols, terpenoids, alkaloids, and some natural extracts on NAFLD through the LKB1/AMPK signaling pathway. This manuscript may shed light on the way to finding a new therapeutic agent for NAFLD management.
C1 [Omidkhoda, Navid] Mashhad Univ Med Sci, Sch Pharm, Dept Clin Pharm, Mashhad, Iran.
   [Mahdiani, Sina; Karimi, Gholamreza] Mashhad Univ Med Sci, Sch Pharm, Dept Pharmacodynam & Toxicol, Mashhad, Iran.
   [Hayes, A. Wallace] Univ S Florida, Coll Publ Hlth, Tampa, FL USA.
   [Hayes, A. Wallace] Michigan State Univ, Inst Integrat Toxicol, Lansing, MI 48824 USA.
   [Karimi, Gholamreza] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Pharmaceut Res Ctr, Mashhad, Iran.
   [Karimi, Gholamreza] Mashhad Univ Med Sci, Pharmaceut Res Ctr, Sch Pharm, Mashhad, Iran.
C3 Mashhad University of Medical Sciences; Mashhad University of Medical
   Sciences; State University System of Florida; University of South
   Florida; Michigan State University; Mashhad University of Medical
   Sciences; Mashhad University of Medical Sciences
RP Karimi, G (corresponding author), Mashhad Univ Med Sci, Pharmaceut Res Ctr, Sch Pharm, Mashhad, Iran.
EM karimig@mums.ac.ir
RI karimi, gholamreza/B-8726-2017
OI Mahdiani, Sina/0000-0002-3098-8326; Omidkhoda, Navid/0000-0002-5310-0537
FU The authors are thankful to the Mashhad University of Medical Sciences.;
   Mashhad University of Medical Sciences
FX The authors are thankful to the Mashhad University of Medical Sciences.
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NR 159
TC 6
Z9 6
U1 9
U2 30
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0951-418X
EI 1099-1573
J9 PHYTOTHER RES
JI Phytother. Res.
PD DEC
PY 2023
VL 37
IS 12
BP 5769
EP 5786
DI 10.1002/ptr.8020
EA SEP 2023
PG 18
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA GJ8D9
UT WOS:001071311800001
PM 37748097
DA 2025-06-11
ER

PT J
AU Sato, A
   Shiraishi, Y
   Kimura, T
   Osaki, A
   Kagami, K
   Ido, Y
   Adachi, T
AF Sato, Atsushi
   Shiraishi, Yasunaga
   Kimura, Toyokazu
   Osaki, Ayumu
   Kagami, Kazuki
   Ido, Yasuo
   Adachi, Takeshi
TI Resistance to Obesity in SOD1 Deficient Mice with a
   High-Fat/High-Sucrose Diet
SO ANTIOXIDANTS
LA English
DT Article
DE SOD1; metabolic syndrome; superoxide anion; ATP; mitochondrial
   intermembrane space; insulin secretion; AMPK; oxygen consumption
ID ACTIVATED PROTEIN-KINASE; INSULIN-RESISTANCE; OXYGEN-CONSUMPTION;
   HYDROGEN-PEROXIDE; AMPK ACTIVATION; SUPEROXIDE; RADICALS; STRESS;
   MECHANISMS; SECRETION
AB Metabolic syndrome (Mets) is an important condition because it may cause stroke and heart disease in the future. Reactive oxygen species (ROSs) influence the pathogenesis of Mets; however, the types of ROSs and their localization remain largely unknown. In this study, we investigated the effects of SOD1, which localize to the cytoplasm and mitochondrial intermembrane space and metabolize superoxide anion, on Mets using SOD1 deficient mice (SOD1(-/-)). SOD1(-/-) fed on a high-fat/high-sucrose diet (HFHSD) for 24 weeks showed reduced body weight gain and adipose tissue size compared to wild-type mice (WT). Insulin secretion was dramatically decreased in SOD1(-/-) fed on HFHSD even though blood glucose levels were similar to WT. Ambulatory oxygen consumption was accelerated in SOD1(-/-) with HFHSD; however, ATP levels of skeletal muscle were somewhat reduced compared to WT. Reflecting the reduced ATP, the expression of phosphorylated AMPK (Thr 172) was more robust in SOD1(-/-). SOD1 is involved in the ATP production mechanism in mitochondria and may contribute to visceral fat accumulation by causing insulin secretion and insulin resistance.
C1 [Sato, Atsushi; Kimura, Toyokazu; Osaki, Ayumu; Kagami, Kazuki; Ido, Yasuo; Adachi, Takeshi] Natl Def Med Coll, Dept Internal Med, Div Cardiovasc Med, 3-2 Namiki, Tokorozawa, Saitama 3598513, Japan.
   [Shiraishi, Yasunaga] Natl Def Med Coll, Div Environm Med, Res Inst, 3-2 Namiki, Tokorozawa, Saitama 3598513, Japan.
C3 National Defense Medical College - Japan; National Defense Medical
   College - Japan
RP Adachi, T (corresponding author), Natl Def Med Coll, Dept Internal Med, Div Cardiovasc Med, 3-2 Namiki, Tokorozawa, Saitama 3598513, Japan.
EM atsushi19821005@yahoo.co.jp; sirayasu10@hotmail.com;
   oyotikuuyakim@gmail.com; ayumu.osaki@gmail.com; mirror.1028k@gmail.com;
   yasaoido@me.com; tadachibu@gmail.com
OI sato, atsushi/0000-0002-2138-3173; Shiraishi,
   Yasunaga/0000-0001-5901-4026; Kimura, Toyokazu/0000-0002-1347-5115
FU Ministry of Defense; Research Fund of the Mitsukoshi Health andWelfare
   Foundation; JSPS KAKENHI [JP 18H02815, JP20K17204]
FX This work was supported in part by a grant from the Ministry of Defense
   and the Research Fund of the Mitsukoshi Health andWelfare Foundation and
   by the JSPS KAKENHI Grant Number JP 18H02815 and JP20K17204.
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NR 47
TC 4
Z9 4
U1 0
U2 2
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD JUL
PY 2022
VL 11
IS 7
AR 1403
DI 10.3390/antiox11071403
PG 15
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA 3J2PI
UT WOS:000833242000001
PM 35883894
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Asadipooya, K
   Lankarani, KB
   Raj, R
   Kalantarhormozi, M
AF Asadipooya, Kamyar
   Lankarani, Kamran B.
   Raj, Rishi
   Kalantarhormozi, Mohammadreza
TI RAGE is a Potential Cause of Onset and Progression of Nonalcoholic Fatty
   Liver Disease
SO INTERNATIONAL JOURNAL OF ENDOCRINOLOGY
LA English
DT Review
ID GLYCATION END-PRODUCTS; SOLUBLE RECEPTOR; OXIDATIVE STRESS;
   HEPATOCELLULAR-CARCINOMA; DIABETIC-RETINOPATHY; GENE POLYMORPHISMS;
   INSULIN-RESISTANCE; RISK-FACTORS; SERUM-LEVELS; SRAGE
AB Objective. Fatty liver is a rising global health concern, significantly increasing the burden of health care cost. Nonalcoholic fatty liver disease (NAFLD) has a correlation with metabolic syndrome and its complications. Method. We reviewed the literature regarding the mechanisms of developing NAFLD through AGE-RAGE signaling. Results. NAFLD, metabolic syndrome, and production of advanced glycation end-products (AGEs) share many common risk factors and appear to be connected. AGE induces production of the receptor for AGE (RAGE). AGE-RAGE interaction contributes to fat accumulation in the liver leading to inflammation, fibrosis, insulin resistance, and other complications of the fatty liver disease. The immune system, especially macrophages, has an important defense mechanism against RAGE pathway activities. Conclusion. Soluble form of RAGE (sRAGE) has the capability to reduce inflammation by blocking the interaction of AGE with RAGE. However, sRAGE has some limitations, and the best method of usage is probably autotransplantation of transfected stem cells or monocytes, as a precursor of macrophages and Kupffer cells, with a virus that carries sRAGE to alleviate the harmful effects of AGE-RAGE signaling in the settings of fatty liver disease.
C1 [Asadipooya, Kamyar] Univ Kentucky, Dept Med, Div Endocrinol & Mol Med, Lexington, KY 40506 USA.
   [Lankarani, Kamran B.] Shiraz Univ Med Sci, Inst Hlth, Hlth Policy Res Ctr, Shiraz, Iran.
   [Raj, Rishi] Univ Kentucky, Dept Med, Div Endocrinol & Mol Med, Lexington, KY 40506 USA.
   [Kalantarhormozi, Mohammadreza] Bushehr Univ Med Sci, Persian Gulf Trop Med Res Ctr, Endocrinol & Internal Med, Bushehr, Iran.
C3 University of Kentucky; Shiraz University of Medical Science; University
   of Kentucky
RP Asadipooya, K (corresponding author), Univ Kentucky, Dept Med, Div Endocrinol & Mol Med, Lexington, KY 40506 USA.
EM kas224@uky.edu
RI lankarani, kamran/D-5901-2012; Asadipooya, Kamyar/AAF-5660-2020;
   KalantarHormozi, MohammadReza/A-4427-2018; Bagheri Lankarani,
   Kamran/P-2066-2017; Raj, Rishi/Q-2409-2018
OI Kalantarhormozi, Mohammadreza/0000-0003-4029-2370; Asadipooya,
   Kamyar/0000-0003-4484-1971; Bagheri Lankarani,
   Kamran/0000-0002-7524-9017; Raj, Rishi/0000-0002-4151-3246
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NR 96
TC 38
Z9 38
U1 2
U2 32
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1687-8337
EI 1687-8345
J9 INT J ENDOCRINOL
JI Int. J. Endocrinol.
PD SEP 18
PY 2019
VL 2019
AR 2151302
DI 10.1155/2019/2151302
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA JB3RP
UT WOS:000488474700001
PM 31641351
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Van Laecke, S
   Van Biesen, W
   Vanholder, R
AF Van Laecke, S.
   Van Biesen, W.
   Vanholder, R.
TI The paradox of bardoxolone methyl: a call for every witness on the
   stand?
SO DIABETES OBESITY & METABOLISM
LA English
DT Review
DE bardoxolone methyl; cardiovascular; diabetes; magnesium
ID CHRONIC KIDNEY-DISEASE; CORONARY-ARTERY-DISEASE; ORAL MAGNESIUM THERAPY;
   HEART-FAILURE; CARDIOVASCULAR MORTALITY; ENDOTHELIAL DYSFUNCTION;
   DIABETIC-NEPHROPATHY; METABOLIC SYNDROME; DIETARY MAGNESIUM; ELDERLY
   SUBJECTS
AB Peoplewith type 2 diabetes and chronic kidney disease (CKD) remain an extremely vulnerable population with increased cardiovascular morbidity, mortality and mounting societal costs. As such, any effort to improve their dismal outcome is heavily supported. Yet, most drugs fail to replicate the promising signals of early experiments in humans in large and methodologically sound trials. As a recent example, an independent data and safety committee advised the termination of a phase 3 trial due to excessive cardiovascular disease and especially heart failure in patients allocated to the antioxidant synthetic triterpenoid bardoxolone methyl versus placebo. We evaluate the reasons why this outcome in hindsight was possibly not totally unexpected and develop a mechanistic model that shows that the consistent drop in serum magnesium concentration in patients exposed to bardoxolone methyl might have contributed to the development of heart failure. As such, this trial, despite its negative outcome, might provide additional pieces of the puzzle enabling us to get a better grip on diseases that share increased inflammation and oxidative stress, such as type 2 diabetes, metabolic syndrome, heart failure and CKD.
C1 [Van Laecke, S.; Van Biesen, W.; Vanholder, R.] Ghent Univ Hosp, Div Renal, B-9000 Ghent, Belgium.
C3 Ghent University; Ghent University Hospital
RP Van Laecke, S (corresponding author), Ghent Univ Hosp, Div Renal, De Pintelaan 185, B-9000 Ghent, Belgium.
EM steven.vanlaecke@ugent.be
OI Van Laecke, Steven/0000-0001-7628-8491
FU Astellas
FX S. V. L. wrote the manuscript, and S. V. L., W. V. B. and R. V. H.
   revised the manuscript. S. V. L. has received lecture honoraria from
   Fresenius and has received grants for clinical research from Astellas.
   He does not have any stocks in any pharmaceutical or device company. W.
   V. B. and R. V. H. have no conflicts of interest to disclose.
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NR 44
TC 18
Z9 19
U1 0
U2 10
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1462-8902
EI 1463-1326
J9 DIABETES OBES METAB
JI Diabetes Obes. Metab.
PD JAN
PY 2015
VL 17
IS 1
BP 9
EP 14
DI 10.1111/dom.12356
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA CA4BD
UT WOS:000348848300003
PM 25041694
DA 2025-06-11
ER

PT J
AU Li, Z
   Zhou, EC
   Liu, C
   Wicks, H
   Yildiz, S
   Razack, F
   Ying, ZX
   Kooijman, S
   Koonen, DPY
   Heijink, M
   Kostidis, S
   Giera, M
   Sanders, IMJG
   Kuijper, EJ
   Smits, WK
   van Dijk, KW
   Rensen, PCN
   Wang, YA
AF Li, Zhuang
   Zhou, Enchen
   Liu, Cong
   Wicks, Hope
   Yildiz, Sena
   Razack, Farhana
   Ying, Zhixiong
   Kooijman, Sander
   Koonen, Debby P. Y.
   Heijink, Marieke
   Kostidis, Sarantos
   Giera, Martin
   Sanders, Ingrid M. J. G.
   Kuijper, Ed J.
   Smits, Wiep Klaas
   van Dijk, Ko Willems
   Rensen, Patrick C. N.
   Wang, Yanan
TI Dietary butyrate ameliorates metabolic health associated with selective
   proliferation of gut Lachnospiraceae bacterium 28-4
SO JCI INSIGHT
LA English
DT Article
ID CHAIN FATTY-ACIDS; BROWN ADIPOSE-TISSUE; INSULIN-RESISTANCE; OXIDATIVE
   STRESS; MICROBIOTA; RECEPTOR; GLUCOSE; MODEL; MICE
AB Short-chain fatty acids, including butyrate, have multiple metabolic benefits in individuals who are lean but not in individuals with metabolic syndrome, with the underlying mechanisms still being unclear. We aimed to investigate the role of gut microbiota in the induction of metabolic benefits of dietary butyrate. We performed antibiotic-induced microbiota depletion of the gut and fecal microbiota transplantation (FMT) in APOE*3-Leiden.CETP mice, a well-established translational model for developing human-like metabolic syndrome, and revealed that dietary butyrate reduced appetite and ameliorated high-fat diet-induced (HFD-induced) weight gain dependent on the presence of gut microbiota. FMT from butyrate-treated lean donor mice, but not butyrate-treated obese donor mice, into gut microbiota-depleted recipient mice reduced food intake, attenuated HFD-induced weight gain, and improved insulin resistance. 16S rRNA and metagenomic sequencing on cecal bacterial DNA of recipient mice implied that these effects were accompanied by the selective proliferation of Lachnospiraceae bacterium 28-4 in the gut as induced by butyrate. Collectively, our findings reveal a crucial role of gut microbiota in the beneficial metabolic effects of dietary butyrate as strongly associated with the abundance of Lachnospiraceae bacterium 28-4.
C1 [Li, Zhuang; Zhou, Enchen; Liu, Cong; Wicks, Hope; Yildiz, Sena; Razack, Farhana; Ying, Zhixiong; Kooijman, Sander; van Dijk, Ko Willems; Rensen, Patrick C. N.; Wang, Yanan] Leiden Univ, Dept Med, Div Endocrinol, Med Ctr, Leiden, Netherlands.
   [Li, Zhuang; Zhou, Enchen; Liu, Cong; Wicks, Hope; Yildiz, Sena; Razack, Farhana; Ying, Zhixiong; Kooijman, Sander; Rensen, Patrick C. N.; Wang, Yanan] Leiden Univ, Med Ctr, Einthoven Lab Expt Vasc Med, Leiden, Netherlands.
   [Li, Zhuang] Southern Med Univ, Zhujiang Hosp, Microbiome Med Ctr, Dept Lab Med, Guangzhou, Peoples R China.
   [Koonen, Debby P. Y.] Univ Med Ctr Groningen, Dept Pediat, Groningen, Netherlands.
   [Heijink, Marieke; Kostidis, Sarantos; Giera, Martin] Leiden Univ, Med Ctr, Ctr Prote & Metabol, Leiden, Netherlands.
   [Sanders, Ingrid M. J. G.; Kuijper, Ed J.; Smits, Wiep Klaas] Leiden Univ, Med Ctr, Dept Med Microbiol, Leiden, Netherlands.
   [Kuijper, Ed J.; Smits, Wiep Klaas] Leiden Univ, Med Ctr, Ctr Microbiome Anal & Therapeut, Leiden, Netherlands.
   [van Dijk, Ko Willems] Leiden Univ, Dept Human Genet, Med Ctr, Leiden, Netherlands.
   [Rensen, Patrick C. N.; Wang, Yanan] Xi An Jiao Tong Univ, Affiliated Hosp 1, Med X Inst, Ctr Immunol & Metab Dis, Xian, Peoples R China.
   [Rensen, Patrick C. N.; Wang, Yanan] Leiden Univ Med Ctr, Dept Med, Div Endocrinol, Albinusdreef 2, NL-2333 ZA Leiden, Netherlands.
C3 Leiden University - Excl LUMC; Leiden University; Leiden University
   Medical Center (LUMC); Leiden University; Leiden University Medical
   Center (LUMC); Leiden University - Excl LUMC; Southern Medical
   University - China; University of Groningen; Leiden University; Leiden
   University Medical Center (LUMC); Leiden University - Excl LUMC; Leiden
   University; Leiden University Medical Center (LUMC); Leiden University -
   Excl LUMC; Leiden University; Leiden University Medical Center (LUMC);
   Leiden University - Excl LUMC; Leiden University; Leiden University
   Medical Center (LUMC); Leiden University - Excl LUMC; Xi'an Jiaotong
   University; Leiden University; Leiden University Medical Center (LUMC)
RP Wang, YA (corresponding author), Leiden Univ Med Ctr, Dept Med, Div Endocrinol, Albinusdreef 2, NL-2333 ZA Leiden, Netherlands.
EM Y.Wang@lumc.nl
RI Goorhuis, Abraham/A-6037-2009; van Dijk, Ko/A-1798-2008; Liu,
   Cong/LMO-3538-2024; Wang, Yanan/C-4143-2019; Kostidis,
   Sarantos/Y-2422-2018; Ying, Zhixiong/V-5029-2018; Kooijman,
   Sander/S-3857-2016; Smits, Wiep Klaas/A-8366-2008; Giera,
   Martin/Y-2413-2018
OI Ying, Zhixiong/0000-0002-3540-7877; Kooijman,
   Sander/0000-0002-0014-5571; Koonen, Debby/0000-0002-1881-8826; Smits,
   Wiep Klaas/0000-0002-7409-2847; Giera, Martin/0000-0003-1684-1894; Zhou,
   Enchen/0000-0002-3739-4934; Wang, Yanan/0000-0002-0327-0458; Liu,
   Cong/0000-0002-2852-8953
FU Leiden University Fund/Mulder-Hamelers Fonds [W18307-2-53, 82170876];
   National Natural Science Foundation of China [91617027]; VENI grant of
   the Netherlands Organization for Scientific Research-NWO [435004007];
   Early Career Scientist Hotel grant of the Netherlands Organization for
   Health Research and Development-ZonMW; Netherlands Cardiovascular
   Research Initiative; Dutch Heart Foundation [CVON-GENIUS-2]; Netherlands
   Heart Foundation [2009T038]; Leiden University Fund/Elise Mathilde Fund;
   National Natural Science Foundation of China's grant; China Scholarship
   Council's grant; Chinese "Thousand Talents Plan" (Young Talents);
   Shaanxi Province "Thousand Talents Plan" (Young Talents) [W213045-2];
   Department of Science and Technology Foundation's grant [82200936]; Plan
   A of the Foundation of Xi'an Jiaotong University [201506170051]; 
   [2021SF-021]
FX This work was supported by the Leiden University Fund/Mulder-Hamelers
   Fonds grant W18307-2-53 (to YW); grant 82170876 of the National Natural
   Science Foundation of China (to YW); VENI grant 91617027 of the
   Netherlands Organization for Scientific Research-NWO (to YW); Early
   Career Scientist Hotel grant 435004007 of the Netherlands Organization
   for Health Research and Development-ZonMW (to YW); the Netherlands
   Cardiovascular Research Initiative, an initiative with support of the
   Dutch Heart Foundation, with grant CVON-GENIUS-2 (to PCNR) and grant
   (CVON-IN-CONTROL II) (to DPYK); the Netherlands Heart Foundation grant
   2009T038 (to PCNR); grant W213045-2 of the Leiden University Fund/Elise
   Mathilde Fund (to ZL); the National Natural Science Foundation of
   China's grant 82200936 (to ZL); and the China Scholarship Council's
   grant 201506170051 (to ZL). The project was also supported by the
   Chinese "Thousand Talents Plan" (Young Talents) (to YW), the Shaanxi
   Province "Thousand Talents Plan" (Young Talents) (to YW), the Department
   of Science and Technology Foundation's grant 2021SF-021 (to YW), and
   Plan A of the Foundation of Xi'an Jiaotong University (to YW).
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NR 48
TC 21
Z9 23
U1 2
U2 23
PU AMER SOC CLINICAL INVESTIGATION INC
PI ANN ARBOR
PA 2015 MANCHESTER RD, ANN ARBOR, MI 48104 USA
EI 2379-3708
J9 JCI INSIGHT
JI JCI Insight
PD FEB 22
PY 2023
VL 8
IS 4
AR e166655
DI 10.1172/jci.insight.166655
PG 17
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 9E1IT
UT WOS:000936547600001
PM 36810253
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU He, SK
   Wang, JH
   Li, T
   Yin, S
   Cui, JW
   Xiao, YF
   Tang, Y
   Wang, J
   Bai, YJ
AF He, Si-Ke
   Wang, Jia-Hao
   Li, Tao
   Yin, Shan
   Cui, Jian-Wei
   Xiao, Yun-Fei
   Tang, Yin
   Wang, Jia
   Bai, Yun-Jin
TI Sleep and circadian rhythm disturbance in kidney stone disease: a
   narrative review
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Review
DE circadian rhythm disturbance; circadian clock; sleep disorder; circadian
   clock gene; kidney stone disease
ID CALCIUM-OXALATE CRYSTAL; VITAMIN-D STATUS; METABOLIC SYNDROME;
   OXALOBACTER-FORMIGENES; INSULIN-RESISTANCE; OXIDATIVE STRESS; ERB-ALPHA;
   EXPERIMENTAL COLITIS; GENERAL-POPULATION; DIABETES-MELLITUS
AB The circadian rhythm generated by circadian clock genes functions as an internal timing system. Since the circadian rhythm controls abundant physiological processes, the circadian rhythm evolved in organisms is salient for adaptation to environmental change. A disturbed circadian rhythm is a trigger for numerous pathological events. Recently, accumulated data have indicated that kidney stone disease (KSD) is related to circadian rhythm disturbance. However, the mechanism between them has not been fully elucidated. In this narrative review, we summarized existing evidence to illustrate the possible association between circadian rhythm disturbance and KSD based on the epidemiological studies and risk factors that are linked to circadian rhythm disturbance and discuss some chronotherapies for KSD. In summary, KSD is associated with systemic disorders. Metabolic syndrome, inflammatory bowel disease, and microbiome dysbiosis are the major risk factors supported by sufficient data to cause KSD in patients with circadian rhythm disturbance, while others including hypertension, vitamin D deficiency, parathyroid gland dysfunction, and renal tubular damage/dysfunction need further investigation. Then, some chronotherapies for KSD were confirmed to be effective, but the molecular mechanism is still unclear.
C1 [He, Si-Ke; Wang, Jia-Hao; Cui, Jian-Wei; Xiao, Yun-Fei; Tang, Yin; Wang, Jia; Bai, Yun-Jin] Sichuan Univ, West China Hosp, Inst Urol, Dept Urol, Chengdu, Peoples R China.
   [Li, Tao] Guizhou Med Univ, Affiliated Hosp, Dept Urol, Guiyang, Peoples R China.
   [Yin, Shan] North Sichuan Med Coll, Dept Urol, Affiliated Hosp, Nanchong, Peoples R China.
C3 Sichuan University; Guizhou Medical University; North Sichuan Medical
   University
RP Bai, YJ (corresponding author), Sichuan Univ, West China Hosp, Inst Urol, Dept Urol, Chengdu, Peoples R China.
EM baiyunjin@wchscu.cn
RI Wang, Jiahao/GSD-4570-2022; Li, Tao/HTQ-4759-2023
FU National Natural Science Foundation of China [82203298]; PostDoctor
   Research Project, West China Hospital, Sichuan University [2020HXBH027];
   Sichuan Science and Technology Program [2022YFS0306]
FX The author(s) declare financial support was received for the research,
   authorship, and/or publication of this article. This study was funded by
   the National Natural Science Foundation of China (Grant no. 82203298),
   the PostDoctor Research Project, West China Hospital, Sichuan University
   (2020HXBH027), and the Sichuan Science and Technology Program
   (2022YFS0306).
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NR 230
TC 7
Z9 7
U1 7
U2 20
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD NOV 27
PY 2023
VL 14
AR 1293685
DI 10.3389/fendo.2023.1293685
PG 14
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA AM1Z0
UT WOS:001118803400001
PM 38089624
OA gold
DA 2025-06-11
ER

PT J
AU De Long, NE
   Holloway, AC
AF De Long, Nicole E.
   Holloway, Alison C.
TI Early-life chemical exposures and risk of metabolic syndrome
SO DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
LA English
DT Review
DE obesity; pesticides; polybrominated diphenyl ethers; heavy metals;
   acrylamide; endocrine-disrupting chemicals
ID POLYBROMINATED DIPHENYL ETHERS; ENDOCRINE-DISRUPTING CHEMICALS; ADVERSE
   PREGNANCY OUTCOMES; DIETARY ACRYLAMIDE INTAKE; CHILDHOOD BLOOD-PRESSURE;
   PRENATAL LEAD-EXPOSURE; DE-NOVO LIPOGENESIS; FLAME RETARDANTS;
   BIRTH-WEIGHT; OXIDATIVE STRESS
AB The global prevalence of obesity has been increasing at a staggering pace, with few indications of any decline, and is now one of the major public health challenges worldwide. While obesity and metabolic syndrome (MetS) have historically thought to be largely driven by increased caloric intake and lack of exercise, this is insufficient to account for the observed changes in disease trends. There is now increasing evidence to suggest that exposure to synthetic chemicals in our environment may also play a key role in the etiology and pathophysiology of metabolic diseases. Importantly, exposures occurring in early life (in utero and early childhood) may have a more profound effect on life-long risk of obesity and MetS. This narrative review explores the evidence linking early-life exposure to a suite of chemicals that are common contaminants associated with food production (pesticides; imidacloprid, chlorpyrifos, and glyphosate) and processing (acrylamide), in addition to chemicals ubiquitously found in our household goods (brominated flame retardants) and drinking water (heavy metals) and changes in key pathways important for the development of MetS and obesity.
C1 [De Long, Nicole E.; Holloway, Alison C.] McMaster Univ, Dept Obstet & Gynecol, RM HSC-3N52,1280 Main St West, Hamilton, ON L8S 4K1, Canada.
C3 McMaster University
RP Holloway, AC (corresponding author), McMaster Univ, Dept Obstet & Gynecol, RM HSC-3N52,1280 Main St West, Hamilton, ON L8S 4K1, Canada.
EM hollow@mcmaster.ca
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NR 133
TC 60
Z9 69
U1 0
U2 41
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-7007
J9 DIABET METAB SYND OB
JI Diabetes Metab. Syndr. Obes.
PY 2017
VL 10
BP 101
EP 109
DI 10.2147/DMSO.S95296
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA EO6OA
UT WOS:000396811200001
PM 28367067
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Delgado-Lista, J
   Perez-Martinez, P
   Garcia-Rios, A
   Perez-Caballero, AI
   Perez-Jimenez, F
   Lopez-Miranda, J
AF Delgado-Lista, Javier
   Perez-Martinez, Pablo
   Garcia-Rios, Antonio
   Perez-Caballero, Ana I.
   Perez-Jimenez, Francisco
   Lopez-Miranda, Jose
TI Mediterranean Diet and Cardiovascular Risk: Beyond Traditional Risk
   Factors
SO CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
LA English
DT Review
DE Mediterranean diet; cardiovascular prevention; cardiovascular risk
   factors; olive oil
ID VIRGIN OLIVE-OIL; POSTPRANDIAL ENDOTHELIAL FUNCTION; POLYUNSATURATED
   FATTY-ACIDS; BLOOD MONONUCLEAR-CELLS; GENE-EXPRESSION CHANGES; METABOLIC
   SYNDROME; RED WINE; FISH-OIL; HEALTHY-SUBJECTS; DISEASE RISK
AB A strict adherence to the Mediterranean Diet (MedDiet) has repeatedly been linked to a low risk of cardiovascular disease in several situations. Initially, the mechanisms considered as possible causes of this were based on the effects of this dietary pattern on the so-called traditional risk factors (especially lipids and blood pressure). However, the high relative reduction in the prevalence of cardiovascular morbidity and mortality were not proportional to the limited findings about regulation of those traditional risk factors. In addition to several studies confirming the above effects, current research on the MedDiet is being focused on defining its effects on non-traditional risk factors, such as endothelial function, inflammation, oxidative stress, or on controlling the conditions which predispose people to cardiovascular events, such as obesity, metabolic syndrome or type 2 diabetes mellitus. In the current article, after briefly reviewing the known effects of the MedDiet on the traditional risk factors, we will mainly focus on reviewing the current evidence about the effects that this dietary pattern exerts on alternative factors, including postprandial lipemia or coagulation, among others, as well as providing a short review on future directions.
C1 [Delgado-Lista, Javier; Perez-Martinez, Pablo; Garcia-Rios, Antonio; Perez-Caballero, Ana I.; Perez-Jimenez, Francisco; Lopez-Miranda, Jose] Univ Cordoba, Ciber Fisiopatol Obesidad & Nutr CIBEROBN, Hosp Univ Reina Sofia, Unidad Lipidos & Arteriosclerosis,IMIBIC,Inst Sal, Cordoba, Spain.
C3 CIBER - Centro de Investigacion Biomedica en Red; CIBEROBN; Universidad
   de Cordoba
RP Lopez-Miranda, J (corresponding author), Hosp Univ Reina Sofia, Unidad Lipidos & Arteriosclerosis, Serv Med Interna, Cordoba 14004, Spain.
EM jlopezmir@uco.es
RI Delgado-Lista, Javier/KAM-7412-2024; Tejada, Silvia/L-7297-2014;
   Jimenez, Francisco/AAJ-9559-2021; Lopez-Miranda, Jose/Y-8306-2019; Perez
   Martinez, Pablo/AEL-6176-2022
OI Delgado Lista, Francisco Javier/0000-0002-2982-2716; Perez-Caballero,
   Ana Isabel/0000-0001-6315-1453; Lopez-Miranda, Jose/0000-0002-8844-0718;
   Perez Martinez, Pablo/0000-0001-7716-8117
FU Spanish Ministry of Science and Innovation [AGL2009-12270, SAF07-62005,
   FIS PI10/01041, PI10/02412]; Consejeria de Economia, Innovacion y
   Ciencia, Proyectos de Investigacion de Excelencia, Junta de Andalucia
   [P06-CTS-01425, CTS5015, AGR922]; Consejeria de Salud, Junta de
   Andalucia [07/43, PI0193/09, PI-0252/09, PI-0058/10]; Fondo Europeo de
   Desarrollo Regional (FEDER); Ministerio de Economia y Competitividad
   [AGL2012/39615]
FX Supported partly by public funding through research grants from the
   Spanish Ministry of Science and Innovation (AGL2009-12270 to J L-M,
   SAF07-62005 to F. Perez-Jimenez and FIS PI10/01041 to P. Perez-Martinez,
   PI10/02412 to F. Perez-Jimenez); Consejeria de Economia, Innovacion y
   Ciencia, Proyectos de Investigacion de Excelencia, Junta de Andalucia
   (P06-CTS-01425 to J. Lopez-Miranda, CTS5015 and AGR922 to F.
   Perez-Jimenez); Consejeria de Salud, Junta de Andalucia (07/43, and
   PI0193/09 to J. Lopez-Miranda, PI-0252/09 to J. Delgado-Lista, and
   PI-0058/10 to P. Perez-Martinez); Fondo Europeo de Desarrollo Regional
   (FEDER). The CIBEROBN is an initiative of the Instituto de Salud Carlos
   III, Madrid, Spain. Also supported by Ministerio de Economia y
   Competitividad (AGL2012/39615 to J L-M).
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NR 135
TC 29
Z9 29
U1 1
U2 25
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1040-8398
EI 1549-7852
J9 CRIT REV FOOD SCI
JI Crit. Rev. Food Sci. Nutr.
PY 2016
VL 56
IS 5
BP 788
EP 801
DI 10.1080/10408398.2012.726660
PG 14
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA DJ1RM
UT WOS:000373981000006
PM 25118147
DA 2025-06-11
ER

PT J
AU Amirullah, NA
   Abdullah, E
   Abidin, NZ
   Abdullah, N
   Manickam, S
AF Amirullah, Nur Amalina
   Abdullah, Erlina
   Abidin, Nurhayati Zainal
   Abdullah, Noorlidah
   Manickam, Sivakumar
TI Therapeutic potential of mushrooms: A review on NF-κB modulation in
   chronic inflammation
SO FOOD BIOSCIENCE
LA English
DT Review
DE Bioactive compounds; Chronic diseases; Fungal metabolites; Inflammation;
   Medicinal mushrooms; Neuroinflammation
ID DEEP EUTECTIC SOLVENT; OXIDATIVE STRESS; ANTIINFLAMMATORY PROPERTIES;
   MEDICINAL MUSHROOM; METABOLIC SYNDROME; EDIBLE MUSHROOMS; P38 MAPK;
   PATHWAY; TARGET; CANCER
AB Numerous mushroom species are valued not just for their flavor but also for their health advantages. Historically, these mushrooms have been utilized for medicinal purposes across different parts of the world. Research has revealed that metabolites derived from these fungi have health benefits. Recently, there has been a growing interest in understanding how these fungal metabolites provide their healing effects and comprehend their mechanisms of action. A primary focus is the nuclear factor NF-kappa B, kappa B, a family of transcription factors essential for regulating inflammation, cell proliferation, and apoptosis. Dysregulation and abnormal activation of NF-kappa B kappa B proteins are associated with a variety of diseases. Various studies have investigated mushroom compounds and their impact on various conditions, including inflammatory bowel disease, gut health, metabolic syndrome, neuroinflammation, liver injury, renal and pulmonary diseases, and autoimmune disorders. This review provides a comprehensive summary of the NF-kappa B kappa B signaling pathway and other related inflammatory pathways. It discusses the bioactive compounds found in mushrooms, their potential to alleviate various diseases, and the specific inflammatory pathways, particularly NF-kappa B, kappa B, that these bioactives target.
C1 [Amirullah, Nur Amalina; Abdullah, Erlina; Abidin, Nurhayati Zainal; Abdullah, Noorlidah] Univ Malaya, Inst Biol Sci, Fac Sci, Kuala Lumpur 50603, Malaysia.
   [Amirullah, Nur Amalina] Univ Putra Malaysia, Fac Med & Hlth Sci, Dept Nutr, Serdang 43400, Malaysia.
   [Abdullah, Erlina] Lincoln Univ Coll, Fac Appl Sci, Dept Biotechnol, Petaling Jaya 47301, Selangor, Malaysia.
   [Manickam, Sivakumar] Univ Teknol Brunei, Fac Engn, Petr & Chem Engn Dept, BE-1410 Bandar Seri Begawan, Brunei.
C3 Universiti Malaya; Universiti Putra Malaysia; Lincoln University
   College; University of Technology Brunei
RP Amirullah, NA (corresponding author), Univ Malaya, Inst Biol Sci, Fac Sci, Kuala Lumpur 50603, Malaysia.
EM amalinaamirullah@upm.edu.my
RI MANICKAM, SIVAKUMAR/I-2228-2014; abdullah, erlina/KCJ-9315-2024; ABIDIN,
   NURHAYATI/B-9429-2010; Abdullah, Noorlidah/B-9290-2010
OI ABDULLAH, ERLINA/0000-0002-6895-1991; MANICKAM,
   SIVAKUMAR/0000-0001-9102-4013
FU Universiti Malaya Special Research Fund Assistance (BKS) [BKS013-2018];
   Universiti Malaya Research University Grant (RU Faculty) [GPF008B-2018];
   Universiti Malaya
FX The authors received support from the Universiti Malaya Special Research
   Fund Assistance (BKS) [BKS013-2018] and the Universiti Malaya Research
   University Grant (RU Faculty) [GPF008B-2018] , which made this work
   possible. The authors thank Universiti Malaya for this support.
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NR 174
TC 3
Z9 3
U1 5
U2 11
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2212-4292
EI 2212-4306
J9 FOOD BIOSCI
JI Food Biosci.
PD DEC
PY 2024
VL 62
AR 105059
DI 10.1016/j.fbio.2024.105059
EA SEP 2024
PG 25
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA H8E9T
UT WOS:001325729400001
DA 2025-06-11
ER

PT J
AU Anania, C
   Perla, FM
   Olivero, F
   Pacifico, L
   Chiesa, C
AF Anania, Caterina
   Perla, Francesco Massimo
   Olivero, Francesca
   Pacifico, Lucia
   Chiesa, Claudio
TI Mediterranean diet and nonalcoholic fatty liver disease
SO WORLD JOURNAL OF GASTROENTEROLOGY
LA English
DT Review
DE Mediterranean diet; Children; Nonalcoholic fatty liver disease; Adults
ID METABOLIC SYNDROME; GUT MICROBIOTA; WEIGHT-LOSS; CARDIOVASCULAR-DISEASE;
   LIFE-STYLE; VITAMIN-E; INTESTINAL MICROBIOTA; INSULIN-RESISTANCE;
   ADHERENCE; HEALTH
AB Nonalcoholic fatty liver disease (NAFLD) is emerging as the most common chronic liver disease, and is characterized by a wide spectrum of fat-liver disorders that can result in severe liver disease and cirrhosis. Inflammation and oxidative stress are the major risk factors involved in the pathogenesis of NAFLD. Currently, there is no consensus concerning the pharmacological treatment of NAFLD. However, lifestyle interventions based on exercise and a balanced diet for quality and quantity, are considered the cornerstone of NAFLD management. Mediterranean diet (MD), rich in polyunsaturated fats, polyphenols, vitamins and carotenoids, with their anti-inflammatory and antioxidant effects, has been suggested to be effective in preventing cardiovascular risk factors. In adults, MD has also been demonstrated to be efficacious in reducing the risk of metabolic syndrome. However, few studies are available on the effects of the MD in both adult and pediatric subjects with NAFLD. Thus, the aims of the present narrative review are to analyze the current clinical evidence on the impact of MD in patients with NAFLD, and to summarize the main mechanisms of action of MD components on this condition.
C1 [Anania, Caterina; Perla, Francesco Massimo; Olivero, Francesca; Pacifico, Lucia] Sapienza Univ Rome, Policlin Umberto Hosp 1, I-00161 Rome, Italy.
   [Chiesa, Claudio] CNR, Inst Translat Pharmacol, Via Fosso del Cavaliere 100, I-00133 Rome, Italy.
C3 Sapienza University Rome; University Hospital Sapienza Rome; Consiglio
   Nazionale delle Ricerche (CNR); Istituto di Farmacologia Traslazionale
   (IFT-CNR)
RP Chiesa, C (corresponding author), CNR, Inst Translat Pharmacol, Via Fosso del Cavaliere 100, I-00133 Rome, Italy.
EM claudio.chiesa@ift.cnr.it
RI Pacifico, Lucia/S-4662-2019
OI ANANIA, Caterina/0000-0002-9607-8632
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NR 89
TC 185
Z9 190
U1 1
U2 37
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 7041 Koll Center Parkway, Suite 160, PLEASANTON, CA, UNITED STATES
SN 1007-9327
EI 2219-2840
J9 WORLD J GASTROENTERO
JI World J. Gastroenterol.
PD MAY 21
PY 2018
VL 24
IS 19
BP 2083
EP 2094
DI 10.3748/wjg.v24.i19.2083
PG 12
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA GG3MG
UT WOS:000432595300004
PM 29785077
OA hybrid, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Gupta, N
   Goel, K
   Shah, P
   Misra, A
AF Gupta, Nidhi
   Goel, Kashish
   Shah, Priyali
   Misra, Anoop
TI Childhood Obesity in Developing Countries: Epidemiology, Determinants,
   and Prevention
SO ENDOCRINE REVIEWS
LA English
DT Review
ID ASIAN INDIAN ADOLESCENTS; C-REACTIVE PROTEIN; NUTRITION EXAMINATION
   SURVEY; IMPAIRED GLUCOSE-TOLERANCE; TYPE-2 DIABETES-MELLITUS;
   PRIMARY-SCHOOL CHILDREN; 3RD NATIONAL-HEALTH; BODY-MASS INDEX; METABOLIC
   SYNDROME; PHYSICAL-ACTIVITY
AB Rapidly changing dietary practices and a sedentary lifestyle have led to increasing prevalence of childhood obesity (5-19 yr) in developing countries recently: 41.8% in Mexico, 22.1% in Brazil, 22.0% in India, and 19.3% in Argentina. Moreover, secular trends indicate increasing prevalence rates in these countries: 4.1 to 13.9% in Brazil during 1974-1997, 12.2 to 15.6% in Thailand during 1991-1993, and 9.8 to 11.7% in India during 2006-2009. Important determinants of childhood obesity include high socioeconomic status, residence in metropolitan cities, female gender, unawareness and false beliefs about nutrition, marketing by transnational food companies, increasing academic stress, and poor facilities for physical activity. Childhood obesity has been associated with type 2 diabetes mellitus, the early-onset metabolic syndrome, subclinical inflammation, dyslipidemia, coronary artery diseases, and adulthood obesity. Therapeutic lifestyle changes and maintenance of regular physical activity through parental initiative and social support interventions are the most important strategies in managing childhood obesity. Also, high-risk screening and effective health educational programs are urgently needed in developing countries. (Endocrine Reviews 33: 48-70, 2012)
C1 [Gupta, Nidhi] Childrens Hosp Michigan, Dept Pediat, Detroit, MI 48201 USA.
   [Gupta, Nidhi] Mayo Clin, Coll Med, Endocrine Res Unit, Rochester, MN 55905 USA.
   [Goel, Kashish] Mayo Clin, Coll Med, Div Cardiovasc Dis, Rochester, MN 55905 USA.
   [Gupta, Nidhi; Goel, Kashish; Shah, Priyali; Misra, Anoop] Diabet Fdn India, New Delhi 110016, India.
   [Shah, Priyali; Misra, Anoop] Natl Diabet Obes & Cholesterol Disorders Fdn N DO, New Delhi 110016, India.
   [Goel, Kashish] Wayne State Univ, Dept Internal Med, Detroit, MI 48202 USA.
   [Misra, Anoop] Fortis Hosp, Fortis C DOC Ctr Excellence Diabet Metab Dis & En, New Delhi 110070, India.
C3 Children's Hospital of Michigan; Mayo Clinic; Mayo Clinic; Wayne State
   University
RP Misra, A (corresponding author), Fortis Flt Lt Rajan Dhall Hosp, Dept Diabet & Metab Dis, New Delhi 110070, India.
EM anoopmisra@metabolicresearchindia.com
RI Goel, Kashish/E-4916-2011; Shah (Pathak), Priyali/KOC-1951-2024
OI Shah (Pathak), Priyali/0000-0003-2806-6100; Gupta,
   Nidhi/0000-0001-6485-3318
FU National Diabetes, Obesity, and Cholesterol Disorders Foundation
   (N-DOC), NewDelhi; Diabetes Foundation (India); World Diabetes
   Foundation, Denmark
FX We acknowledge the support and cooperation of National Diabetes,
   Obesity, and Cholesterol Disorders Foundation (N-DOC), NewDelhi,
   Diabetes Foundation (India), and World Diabetes Foundation, Denmark in
   various research initiatives in childhood obesity undertaken by our
   group.
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NR 160
TC 414
Z9 483
U1 1
U2 180
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0163-769X
EI 1945-7189
J9 ENDOCR REV
JI Endocr. Rev.
PD FEB
PY 2012
VL 33
IS 1
BP 48
EP 70
DI 10.1210/er.2010-0028
PG 23
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism
GA 894CH
UT WOS:000300404100002
PM 22240243
DA 2025-06-11
ER

PT J
AU Chang, TI
   Tanner, JM
   Harada, ND
   Garrett, NR
   Friedlander, AH
AF Chang, Tina I.
   Tanner, Jeffrey M.
   Harada, Nancy D.
   Garrett, Neal R.
   Friedlander, Arthur H.
TI Prevalence of calcified carotid artery atheromas on the panoramic images
   of patients with syndrome Z, coexisting obstructive sleep apnea, and
   metabolic syndrome
SO ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY
LA English
DT Article
ID INSULIN-RESISTANCE; RISK-FACTORS; CARDIOVASCULAR-DISEASE; INTERMITTENT
   HYPOXIA; OXIDATIVE STRESS; ATHEROSCLEROSIS; COMPLICATIONS; INFLAMMATION;
   ASSOCIATION; POPULATION
AB Objectives. The objective of this study was to compare the prevalence of calcified carotid artery atheromas (CCAAs) on panoramic images of individuals (n = 31) with obstructive sleep apnea (OSA) with individuals (n = 117) with syndrome Z (SZ: OSA with concomitant metabolic syndrome [MetS]).
   Study design. Images of patients with OSA or SZ referred from the Sleep Service to Dentistry were evaluated. Descriptive statistics and t tests (Bonferroni correction) were conducted to determine significant differences between atheroma prevalence and proatherogenic factors (age, apnea-hypopnea index, body mass index, lipid profile, blood pressure, glucose) between OSA and SZ groups.
   Results. Individuals with OSA had an atheroma prevalence of 35% and those with SZ 42% (P = .52). Individuals with SZ also had significantly more severe atherogenic profiles (obesity, dyslipidemia, hyperglycemia) than OSA patients (P <= .05). Greatest CCAA prevalence (63%) was evidenced by SZ patients with severe OSA and moderate MetS.
   Conclusion. Individuals with SZ have significantly greater atherogenic burden and slightly higher prevalence of CCAAs when compared with individuals with OSA. (Oral Surg Oral Med Oral Pathol Oral Radiol 2012;113:134-141)
C1 [Tanner, Jeffrey M.; Friedlander, Arthur H.] VA Greater Los Angeles Healthcare Syst, Dent Serv, Oral & Maxillofacial Surg Sect, Los Angeles, CA 90073 USA.
   [Harada, Nancy D.] Vet Affairs Greater Los Angeles Healthcare Syst, Geriatr Res Educ & Clin Ctr, Los Angeles, CA 90073 USA.
   [Garrett, Neal R.] Univ Calif Los Angeles, Sch Dent, Div Adv Prosthodont Biomat & Hosp Dent, Los Angeles, CA 90024 USA.
   [Harada, Nancy D.] Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90095 USA.
   [Friedlander, Arthur H.] Ronald Reagan UCLA Med Ctr, Hosp Dent Serv, Torrance, CA USA.
C3 US Department of Veterans Affairs; Veterans Health Administration (VHA);
   VA Greater Los Angeles Healthcare System; Geriatric Research Education &
   Clinical Center; US Department of Veterans Affairs; Veterans Health
   Administration (VHA); VA Greater Los Angeles Healthcare System;
   University of California System; University of California Los Angeles;
   University of California System; University of California Los Angeles;
   University of California Los Angeles Medical Center; David Geffen School
   of Medicine at UCLA; University of California System; University of
   California Los Angeles; University of California Los Angeles Medical
   Center; Ronald Reagan UCLA Medical Center
RP Friedlander, AH (corresponding author), VA Greater Los Angeles Healthcare Syst, Dent Serv, Oral & Maxillofacial Surg Sect, 11301 Wilshire Blvd, Los Angeles, CA 90073 USA.
EM arthur.friedlander@va.gov
FU Department of Veterans Affairs; University of California; National
   Center for Research Resources, National Institutes of Health [C06
   RR-14529-01]
FX The financial support of this project was limited to the full-time
   salaries paid to the authors by the Department of Veterans Affairs and
   the University of California. Elements of this investigation were
   conducted in a facility constructed with support from Research
   Facilities Improvement Program Grant Number C06 RR-14529-01 from the
   National Center for Research Resources, National Institutes of Health.
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NR 59
TC 4
Z9 5
U1 0
U2 2
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 2212-4403
EI 1528-395X
J9 OR SURG OR MED OR PA
JI Oral Surg. Oral Med. Oral Pathol. Oral Radiol.
PD JAN
PY 2012
VL 113
IS 1
BP 134
EP 141
DI 10.1016/j.tripleo.2011.07.039
PG 8
WC Dentistry, Oral Surgery & Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dentistry, Oral Surgery & Medicine
GA 898ZW
UT WOS:000300781900016
PM 22669072
OA Bronze
DA 2025-06-11
ER

PT J
AU Cheung, G
   Gee, S
   Jamieson, H
   Berger, U
AF Cheung, Gary
   Gee, Susan
   Jamieson, Hamish
   Berger, Ulrich
TI What Is Frailty? Perspectives from Chinese Clinicians and Older
   Immigrants in New Zealand
SO JOURNAL OF CROSS-CULTURAL GERONTOLOGY
LA English
DT Article
DE Ethnicity; Frailty; Health professionals; Older people; Overseas Chinese
ID METABOLIC SYNDROME; ADULTS; PREVALENCE; DEPRESSION; PEOPLE; RISK
AB This qualitative study explores the meanings of frailty held by Chinese New Zealanders and Chinese health care professionals with the aim of identifying commonalities as well as potential differences. Two guided focus groups with Mandarin and Cantonese speaking older adults (n = 10), one individual interview with a English speaking older Chinese, and one focus group with Chinese New Zealand health care professionals (n = 7) were held to obtain views on frailty in older adults, followed by transcribing and a thematic qualitative analysis. Three main themes emerged: (1) Frailty is marked by ill-health, multiple chronic and unstable medical comorbidities, and is a linked with polypharmacy; (2) Frailty can involve physical weakness, decline in physical function such as reduced mobility or poor balance, and declining cognitive function; and (3) Frailty is associated with psychological and social health including depression, reduced motivation, social isolation, and loss of confidence. The perspectives of frailty that emerged are congruent with a multi-dimensional concept of frailty that has been described in both Chinese and non-Chinese medical research literature.
C1 [Cheung, Gary] Univ Auckland, Dept Psychol Med, Auckland Mail Ctr, Private Bag 92019, Auckland 1142, New Zealand.
   [Gee, Susan; Jamieson, Hamish; Berger, Ulrich] Univ Otago, Christchurch, New Zealand.
   [Gee, Susan; Jamieson, Hamish] Canterbury Dist Hlth Board, Christchurch, New Zealand.
C3 University of Auckland; University of Otago
RP Cheung, G (corresponding author), Univ Auckland, Dept Psychol Med, Auckland Mail Ctr, Private Bag 92019, Auckland 1142, New Zealand.
EM g.cheung@auckland.ac.nz
OI jamieson, hamishj/0000-0002-2462-1595; Bergler, Hans/0000-0002-6478-8541
FU Older People Mental Health Services Research Trust, Canterbury District
   Health Board, New Zealand [6409313.4920.00000]
FX This study was funded by the Older People Mental Health Services
   Research Trust, Canterbury District Health Board, New Zealand (grant
   number 6409313.4920.00000).
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NR 51
TC 6
Z9 6
U1 0
U2 11
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0169-3816
EI 1573-0719
J9 J CROSS-CULT GERONTO
JI J. Cross-Cult. Gerontol.
PD JUN
PY 2021
VL 36
IS 2
BP 201
EP 213
DI 10.1007/s10823-021-09424-0
EA APR 2021
PG 13
WC Gerontology
WE Emerging Sources Citation Index (ESCI)
SC Geriatrics & Gerontology
GA SS1EY
UT WOS:000638123800001
PM 33830425
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Torfadottir, JE
   Ulven, SM
AF Torfadottir, Johanna E.
   Ulven, Stine M.
TI Fish - a scoping review for Nordic Nutrition Recommendations 2023
SO FOOD & NUTRITION RESEARCH
LA English
DT Review
DE fish; seafood; polyunsaturatedfatty acids; dietary recommendations
ID CANCER RISK; FOOD GROUPS; CONSUMPTION; METAANALYSIS;
   OMEGA-3-FATTY-ACIDS; ASSOCIATION; ACID
AB The aim of this scoping review was to conduct evidence-based documentation between fish intake and health outcomes for food-based dietary guidelines (FBDGs) in the Nordic Nutrition Recommendations (NNR) 2023. For most health outcomes, the evidence for fish oil and n-3 long chain (LC) polyunsaturated fatty acids (PUFA) supplementation was included when examining evidence between fish intake and health. In this review, conclusions from qualified systematic reviews (qSR) approved by NNR2023 are included. In addition, conclusions of a de novo systematic reviews on the topic of n-3 LC-PUFA, asthma, and allergy are included. Finally, a systematic literature search was performed limited to systematic reviews and meta-analysis published between 2011 and September 2021. In total, 21 papers from the systematic literature search, four qSR, and eight reports were included addressing the association between fish intake, fish oil, and n-3 LC-PUFA supplementation on several health outcomes. These included cardiovascular disease (CVD), type 2 diabetes, cancers (colorectal, breast, and prostate), metabolic syndrome, obesity, mortality, cognition and mental health, pregnancy-related outcomes (preterm birth and birth weight), and outcomes specific for children (neurodevelopment, and risk of food allergies, and asthma). In addition, intermediate risk factors such as blood lipids, glucose, C -reactive protein, and blood pressure were reviewed. Based on current evidence, fish consumption can have beneficial effects to prevent coronary heart disease (CHD) and stroke incidence, and lower mortality from CVD, CHD, myocardial infarction (MI), and stroke, as well as total mortality risk. In addition, fish consumption is beneficial for preventing cognitive decline in adults (e.g. dementia and Alzheimer's disease). Fish intake may also prevent metabolic syndrome, supported by an observed association between fish intake and reduction in plasma triglycerides and increase in high-density lipoprotein (HDL) cholesterol levels. Data from fish oil and n-3 LC-PUFA supplementation studies supports the conclusions on the effects of fish consumption on most of the health outcomes.
C1 [Torfadottir, Johanna E.] Univ Iceland, Ctr Publ Hlth Sci, Reykjavik, Iceland.
   [Torfadottir, Johanna E.] Directorate Hlth, Reykjavik, Iceland.
   [Ulven, Stine M.] Univ Oslo, Dept Nutr, Oslo, Norway.
   [Torfadottir, Johanna E.] Univ Iceland, Directorate Hlth, Reykjavik, Iceland.
C3 University of Iceland; University of Oslo; University of Iceland
RP Torfadottir, JE (corresponding author), Univ Iceland, Directorate Hlth, Reykjavik, Iceland.
EM jet@hi.is
RI Ulven, Stine/ABD-7140-2020
CR 2020 Dietary Guidelines Advisory Committee and Nutrition Evidence Systematic Review Team, 2020, Seafood consumption during pregnancy and lactation and neurocognitive development in the child: a systematic review. 2020 Dietary Guidelines Advisory Committee Project
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NR 49
TC 1
Z9 1
U1 4
U2 14
PU SWEDISH NUTRITION FOUNDATION-SNF
PI LUND
PA IDEON SCIENCE PARK, BESOK SCHEELEV 17 BETA 5, 3V, LUND, 223 70, SWEDEN
SN 1654-6628
EI 1654-661X
J9 FOOD NUTR RES
JI Food Nutr. Res.
PD MAR 5
PY 2024
VL 68
AR 10485
DI 10.29219/fnr.v68.10485
PG 18
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA PW7H6
UT WOS:001217179600001
PM 38571914
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Elsaka, O
AF Elsaka, Omar
TI Novel Biomarkers in Vascular Diseases: From Discovery to Clinical
   Translation
SO INDIAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
LA English
DT Review
DE Atherosclerosis; biomarkers; cardiovascular diseases; clinical
   applications; diagnostic markers; endothelial activation; endothelial
   dysfunction; inflammation; insulin resistance; metabolic syndrome;
   nitric oxide; oxidative stress; pathogenesis; prediabetes; predictive
   markers; translational research; treatment strategies; type II diabetes;
   vascular diseases; vasodilation
AB Endothelial activation as well as dysfunction is a major factor in atherosclerosis, cardiovascular disorders, and cardiorenal syndrome. Endothelial dysfunction is additionally associated with metabolic syndrome as well as type II diabetes. The hunt for distinctive as well as sensitive biomarkers of endothelial activity and dysfunction may have substantial therapeutic consequences. This review pinpoints the variations in biomarkers that occur between endothelial activation and endothelial dysfunction in cardiovascular illnesses, and then briefly highlights the most significant biomarkers of endothelial activation. Biomarkers of endothelial activation consist of endothelial adhesion molecules, as well as cytokines, and C-reactive protein, along with CD62E++/E-selectin activated endothelial microparticles, and oxidation of low-density lipoproteins, together with asymmetric dimethylarginine as well as endocan. This study also includes an update on the new biomarkers of endothelial dysfunction, such as matrix metalloproteinases (MMP) (e.g., MMP-7, MMP-9), along with ANGPTL2, and endoglin, together with annexin V++ endothelium apoptotic microparticles, and serum homocysteine. Finally, this study stresses the limits of biomarkers of endothelium activation and dysfunction in clinical situations.
C1 [Elsaka, Omar] Mansoura Univ, Dept Cardiol, Mansoura Manchester Med Program MMMP, Fac Med, Mansoura, Egypt.
C3 Egyptian Knowledge Bank (EKB); Mansoura University
RP Elsaka, O (corresponding author), Mansoura Univ, Dept Cardiol, Mansoura Manchester Med Program MMMP, Fac Med, Mansoura, Egypt.
EM omarelsaka0808@gmail.com
RI Elsaka, Omar/ABP-4248-2022
OI Elsaka, Omar/0000-0003-1042-4715
CR Alexander Y, 2021, CARDIOVASC RES, V117, P29, DOI 10.1093/cvr/cvaa085
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NR 37
TC 0
Z9 0
U1 0
U2 0
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, Maharashtra, INDIA
SN 0972-0820
EI 2394-0999
J9 INDIAN J VASCULAR EN
JI Indian J. Vascular Endovasc. Surg.
PD JUL-SEP
PY 2024
VL 11
IS 3
BP 142
EP 151
DI 10.4103/ijves.ijves_42_24
PG 10
WC Cardiac & Cardiovascular Systems; Surgery
WE Emerging Sources Citation Index (ESCI)
SC Cardiovascular System & Cardiology; Surgery
GA K9O0I
UT WOS:001347106500002
OA gold
DA 2025-06-11
ER

PT J
AU Panagiotou, C
   Mihailidou, C
   Brauhli, G
   Katsarou, O
   Moutsatsou, P
AF Panagiotou, Christina
   Mihailidou, Chrysovalantou
   Brauhli, George
   Katsarou, Olga
   Moutsatsou, Paraskevi
TI RETRACTED: Effect of steviol, steviol glycosides and stevia extract on
   glucocorticoid receptor signaling in normal and cancer blood cells
   (Retracted Article)
SO MOLECULAR AND CELLULAR ENDOCRINOLOGY
LA English
DT Article; Retracted Publication
DE Glucocorticoid receptor; Steviol; Steviol glycosides; PBMCs; Type 2
   diabetes mellitus; Metabolic syndrome
ID PITUITARY-ADRENAL AXIS; INDUCED LEUCINE-ZIPPER; PERIPHERAL-BLOOD;
   NATURAL SWEETENER; GENE-EXPRESSION; REBAUDIOSIDE-A; DEXAMETHASONE;
   HEALTHY; APOPTOSIS; STRESS
AB The use of steviol glycosides as non-caloric sweeteners has proven to be beneficial for patients with type 2 diabetes mellitus (T2D), obesity, and metabolic syndrome. However, recent data demonstrate that steviol and stevioside might act as glucocorticoid receptor (GR) agonists and thus correlate with adverse effects on metabolism. Herein, we evaluated the impact of steviol, steviol glycosides, and a Greek-derived stevia extract on a number of key steps of GR signaling cascade in peripheral blood mononuclear cells (PBMCs) and in Jurkat leukemia cells. Our results revealed that none of the tested compounds altered the expression of primary GR-target genes (GILZ, FKPB5), GR protein levels or GR subcellular localization in PBMCs; those compounds increased GILZ and FKPB5 mRNA levels as well as GRE-mediated luciferase activity, inducing in parallel GR nuclear translocation in Jurkat cells. The GR-modulatory activity demonstrated by stevia-compounds in Jurkat cells but not in PBMCs may be due to a cell-type specific effect. (C) 2017 Elsevier B.V. All rights reserved.
C1 [Panagiotou, Christina; Moutsatsou, Paraskevi] Natl & Kapodistrian Univ Athens, Univ Gen Hosp ATTIKO, Med Sch, Dept Clin Biochem, Athens, Greece.
   [Mihailidou, Chrysovalantou] Natl & Kapodistrian Univ Athens, Med Sch, Dept Biol Chem, Athens, Greece.
   [Brauhli, George] ANTHIR SA Co, Agrinion, Greece.
   [Katsarou, Olga] Laikon Gen Hosp, Blood Transfus Ctr 2, Athens, Greece.
   [Katsarou, Olga] Laikon Gen Hosp, Hemophilia Ctr, Athens, Greece.
C3 University Hospital Attikon; National & Kapodistrian University of
   Athens; National & Kapodistrian University of Athens; Laiko General
   Hospital; Laiko General Hospital
RP Moutsatsou, P (corresponding author), Univ Athens, Med Sch, Univ Hosp ATTIKO, Athens 12462, Greece.
EM pmoutsatsou@med.uoa.gr
RI MOUTSATSOU, PARASKEVI/JFA-5539-2023
FU Greek Secretariat of Research and Technology, Ministry of Development
   (Grant ESPA) [11SigmaYN_2_741]; GIOTIS S.A.
FX This research is supported by the Greek Secretariat of Research and
   Technology, Ministry of Development (Grant ESPA, 11 Sigma YN_2_741) in
   cooperation with the company GIOTIS S.A. The funders had no role in
   study design, data collection and analysis, decision to publish, or
   preparation of the manuscript.
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NR 44
TC 27
Z9 27
U1 0
U2 33
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0303-7207
EI 1872-8057
J9 MOL CELL ENDOCRINOL
JI Mol. Cell. Endocrinol.
PD JAN 15
PY 2018
VL 460
IS C
BP 189
EP 199
DI 10.1016/j.mce.2017.07.023
PG 11
WC Cell Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Endocrinology & Metabolism
GA FU5LD
UT WOS:000423893300018
PM 28754349
DA 2025-06-11
ER

PT J
AU Huber, K
   Szerenos, E
   Lewandowski, D
   Toczylowski, K
   Sulik, A
AF Huber, Korbinian
   Szerenos, Emilia
   Lewandowski, Dawid
   Toczylowski, Kacper
   Sulik, Artur
TI The Role of Adipokines in the Pathologies of the Central Nervous System
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE adipokines; adipose tissue; Alzheimer's disease; depression; protein
   hormones; multiple sclerosis; neurological dysfunctions; meningitis;
   encephalitis
ID CYSTATIN C LEVELS; PEPTIDASE-IV ACTIVITY; F344 RAT SUBSTRAINS;
   CEREBROSPINAL-FLUID; CHITINASE-3-LIKE PROTEIN-1; METABOLIC SYNDROME;
   NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE; POTENTIAL BIOMARKER; SERUM
   OMENTIN-1; NEUROPEPTIDE-Y
AB Adipokines are protein hormones secreted by adipose tissue in response to disruptions in physiological homeostasis within the body's systems. The regulatory functions of adipokines within the central nervous system (CNS) are multifaceted and intricate, and they have been identified in a number of pathologies. Therefore, specific adipokines have the potential to be used as biomarkers for screening purposes in neurological dysfunctions. The systematic review presented herein focuses on the analysis of the functions of various adipokines in the pathogenesis of CNS diseases. Thirteen proteins were selected for analysis through scientific databases. It was found that these proteins can be identified within the cerebrospinal fluid either by their ability to modify their molecular complex and cross the blood-brain barrier or by being endogenously produced within the CNS itself. As a result, this can correlate with their measurability during pathological processes, including Alzheimer's disease, amyotrophic lateral sclerosis, multiple sclerosis, depression, or brain tumors.
C1 [Huber, Korbinian; Szerenos, Emilia; Lewandowski, Dawid; Toczylowski, Kacper; Sulik, Artur] Med Univ Bialystok, Dept Pediat Infect Dis, Waszyngtona 17, PL-15274 Bialystok, Poland.
C3 Medical University of Bialystok
RP Toczylowski, K (corresponding author), Med Univ Bialystok, Dept Pediat Infect Dis, Waszyngtona 17, PL-15274 Bialystok, Poland.
EM kacper.toczylowski@umb.edu.pl
RI Lewandowski, Dawid/KWT-9716-2024; Sulik, Artur/S-6083-2018; Toczylowski,
   Kacper/S-4595-2018
OI Sulik, Artur/0000-0002-8391-4793; Toczylowski,
   Kacper/0000-0003-0309-6987; Lewandowski, Dawid/0009-0006-9004-8623
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NR 151
TC 9
Z9 9
U1 1
U2 4
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD OCT
PY 2023
VL 24
IS 19
AR 14684
DI 10.3390/ijms241914684
PG 27
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA U8MQ3
UT WOS:001087292000001
PM 37834128
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Savoy, SM
   Penckofer, S
AF Savoy, Suzanne M.
   Penckofer, Sue
TI Depressive Symptoms Impact Health-Promoting Lifestyle Behaviors and
   Quality of Life in Healthy Women
SO JOURNAL OF CARDIOVASCULAR NURSING
LA English
DT Article
DE depression; quality of life; risk factors; women
ID CORONARY-HEART-DISEASE; ACUTE MYOCARDIAL-INFARCTION; RISK-FACTOR;
   CARDIOVASCULAR RISK; PHYSICAL-ACTIVITY; METABOLIC SYNDROME; 52
   COUNTRIES; MORTALITY; ASSOCIATION; ANXIETY
AB Background: Depressive symptoms are an independent risk factor of cardiovascular disease (CVD). More than 15% of persons with CVD have depressive symptoms, which are twice as likely to occur in women. Depressive symptoms in women being screened for CVD have not been well studied.
   Objective: The relationships between depressive symptoms, health-promoting lifestyle behaviors, heart disease risk awareness, cardiac risk, and quality of life (QOL) in women were investigated. Whether the effect of depressive symptoms on QOL was mediated by cardiac risk and/or health-promoting lifestyle behaviors was also examined.
   Methods: The Wilson-Cleary Health-Related Quality of Life Model guided this descriptive study. A convenience sample of 125 women was recruited from cardiac health screening events. The study measurements were the Center for Epidemiologic Studies Depression Scale; the Framingham risk score; the Ferrans-Powers Quality of Life Index Generic Version-III; the Health-Promoting Lifestyle Profile-II; and questions related to heart disease risk, awareness of heart disease risk, health history, and demographics. Body mass index, percentage of body fat, and lipid profile were also measured.
   Results: More than one-third (34%) of the women reported significant depressive symptoms. Depressive symptoms were not associated with cardiac risk or risk awareness but were inversely associated with health-promoting lifestyle behaviors (r = -0.37, P < 0.01) and QOL (r = -0.51, P < 0.01). There was a dose-response relationship with health-promoting lifestyle behaviors (odds ratio, 0.92; 95% confidence interval, 0.88-0.97; P < 0.001) and QOL (odds ratio, 0.85; 95% confidence interval, 0.79-0.92; P < 0.001) and depressive symptoms. Health-promoting lifestyle behaviors mediated the association between depressive symptoms and QOL.
   Conclusions: Depressive symptoms contribute significantly to health-promoting lifestyle behaviors and QOL for women. Early detection and treatment of depressive symptoms are important for participation in healthy lifestyle behaviors, which could result in improved QOL.
C1 [Savoy, Suzanne M.] Saginaw Valley State Univ, Coll Hlth & Human Serv, Dept Nursing, University Ctr, PA 48710 USA.
   [Penckofer, Sue] Loyola Univ Chicago Niehoff, Sch Nursing, Maywood, IL USA.
C3 Loyola University Chicago
RP Savoy, SM (corresponding author), Saginaw Valley State Univ, 7400 Bay Rd,HHS Rm 233, University Ctr, PA 48710 USA.
EM smsavoy@svsu.edu
FU Columbia-Presbyterian Hospital School of Nursing Alumni Association,
   Inc; Saginaw Valley State University; Theta Chi Chapter, Sigma Theta Tau
   International
FX Supported by graduate scholarship from Columbia-Presbyterian Hospital
   School of Nursing Alumni Association, Inc, and by research grants from
   Saginaw Valley State University and Theta Chi Chapter, Sigma Theta Tau
   International.
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NR 82
TC 22
Z9 29
U1 0
U2 23
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0889-4655
EI 1550-5049
J9 J CARDIOVASC NURS
JI J. Cardiovasc. Nurs.
PD JUL-AUG
PY 2015
VL 30
IS 4
BP 360
EP 372
DI 10.1097/JCN.0000000000000158
PG 13
WC Cardiac & Cardiovascular Systems; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Cardiovascular System & Cardiology; Nursing
GA CL1PK
UT WOS:000356715800012
PM 24850376
DA 2025-06-11
ER

PT J
AU Bates, R
   Salsberry, P
   Ford, J
AF Bates, Randi
   Salsberry, Pamela
   Ford, Jodi
TI Measuring Stress in Young Children Using Hair Cortisol: The State of the
   Science
SO BIOLOGICAL RESEARCH FOR NURSING
LA English
DT Article
DE hair cortisol; chronic stress; young children
ID ADVERSE CHILDHOOD EXPERIENCES; PITUITARY-ADRENAL AXIS; OF-THE-ART;
   SOCIOECONOMIC-STATUS; FUTURE-DIRECTIONS; DEVELOPMENTAL PATHWAYS; HEALTH
   DEVELOPMENT; METABOLIC SYNDROME; CUSHINGS-SYNDROME; ALLOSTATIC LOAD
AB Extensive literature suggests that adverse experiences in early childhood may deleteriously impact later health. These effects are thought to be related to the impact of persistent or chronic stress on various biological processes, mediated by dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis, and ultimately irregularities in cortisol levels. Ameliorating persistent stress in young children requires accurately measuring the chronicity of physiologic stress, which is difficult in young children because of unreliable self-report and the burden and inaccuracy associated with using invasive acute-stress biomeasures. A better way to approximate persistent stress in young children is measuring hair cortisol concentration (HCC), as it only requires one noninvasive collection to measure months of HPA-axis activity or experienced stress. However, few studies measure HCC in young children despite wide use in adult stress research. This article reviews and synthesizes research that uses HCC to approximate persistent stress in healthy children, 12-60 months of age. Reviewed studies indicate that HCC is elevated in young children who are experiencing forms of persistent stress such as low socioeconomic status and maternal distress. Hair cortisol is thus a promising measure of early childhood persistent stress, but due to the limited use of HCC in this population, much research is still needed. Specifically, nurse researchers may need to measure several factors associated with early childhood persistent stress and HCC to identify which children are at risk for stress-related disease.
C1 [Bates, Randi; Ford, Jodi] Ohio State Univ, Coll Nursing, Newton Hall,1585 Neil Ave, Columbus, OH 43210 USA.
   [Salsberry, Pamela] Ohio State Univ, Coll Publ Hlth, Columbus, OH 43210 USA.
C3 University System of Ohio; Ohio State University; University System of
   Ohio; Ohio State University
RP Bates, R (corresponding author), Ohio State Univ, Coll Nursing, Newton Hall,1585 Neil Ave, Columbus, OH 43210 USA.
EM bates.204@osu.edu
RI Bates, Randi/I-2200-2019; Ford, Jodi/AAO-9830-2021
OI Bates, Randi/0000-0002-6672-8155; Ford, Jodi/0000-0002-0778-4667
FU Crane Center for Early Childhood Research and Policy; Jonas Doctoral
   Nurse Scholar Program
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: This
   research received no specific grant from any funding agency in the
   public, commercial, or not-for-profit sectors. Randi Bates is supported
   by a graduate research associateship with the Crane Center for Early
   Childhood Research and Policy and by a scholarship from the Jonas
   Doctoral Nurse Scholar Program.
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NR 86
TC 72
Z9 79
U1 0
U2 31
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1099-8004
EI 1552-4175
J9 BIOL RES NURS
JI Biol. Res. Nurs.
PD OCT
PY 2017
VL 19
IS 5
BP 499
EP 510
DI 10.1177/1099800417711583
PG 12
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA FQ2IU
UT WOS:000418180900003
PM 28617035
OA Green Published
DA 2025-06-11
ER

PT J
AU Das, UN
AF Das, UN
TI Long-chain polyunsaturated fatty acids interact with nitric oxide,
   superoxide anion, and transforming growth factor-β to prevent human
   essential hypertension
SO EUROPEAN JOURNAL OF CLINICAL NUTRITION
LA English
DT Review
DE long-chain polyunsaturated fatty acids; hypertension; angiotensin
   converting enzyme; nitric oxide; eicosapentaenoic acid; Docosahexaenoic
   acid
ID CONVERTING ENZYME-INHIBITOR; ENDOTHELIUM-DEPENDENT VASODILATION;
   METABOLIC SYNDROME-X; LATER BLOOD-PRESSURE; SMOOTH-MUSCLE-CELLS;
   ANGIOTENSIN-II; CALCIUM-ANTAGONIST; DIABETES-MELLITUS; OXIDATIVE STRESS;
   L-ARGININE
AB Patients with uncontrolled essential hypertension have elevated concentrations of superoxide anion (O-2(-circle)), hydrogen peroxide (H2O2), lipid peroxides, endothelin, and transforming growth factor-beta (TGF-beta) with a simultaneous decrease in endothelial nitric oxide (eNO), superoxide dismutase (SOD), vitamin E, and long-chain polyunsaturated fatty acids (LCPUFAs). Physiological concentrations of angiotensin II activate NAD(P) H oxidase and trigger free radical generation (especially that of O-2(-circle)). Normally, angiotensin II-induced oxidative stress is abrogated by adequate production and release of eNO, which quenches O-2(-circle) to restore normotension. Angiotensin II also stimulates the production of endothelin and TGF-beta. TGF-beta enhances NO generation, which in turn suppresses TGF-beta production. Thus, NO has a regulatory role on TGF-beta production and is also a physiological antagonist of endothelin. Antihypertensive drugs suppress the production of O-2(-circle) K and TGF-beta and enhance eNO synthesis to bring about their beneficial actions. LCPUFAs suppress angiotensin-converting enzyme (ACE) activity, reduce angiotensin II formation, enhance eNO generation, and suppress TGF-beta expression. Perinatal supplementation of LCPUFAs decreases insulin resistance and prevents the development of hypertension in adult life, whereas deficiency of LCPUFAs in the perinatal period results in raised blood pressure later in life. Patients with essential hypertension have low concentrations of various LCPUFAs in their plasma phospholipid fraction. Based on this, it is proposed that LCPUFAs serve as endogenous regulators of ACE activity, O-2(-circle), eNO generation, and TGF-beta expression. Further, LCPUFAs have actions similar to statins, inhibit (especially omega-3 fatty acids) cyclooxygenase activity and suppress the synthesis of proinflammatory cytokines, and activate the parasympathetic nervous system, all actions that reduce the risk of major vascular events. Hence, it is proposed that availability of adequate amounts of LCPUFAs during the critical periods of growth prevents the development of hypertension in adulthood.
C1 EFA Sci LLC, Norwood, MA 02062 USA.
RP EFA Sci LLC, 1420 Prov Highway,Suite 266, Norwood, MA 02062 USA.
EM undas@efasciences.com
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NR 103
TC 88
Z9 96
U1 1
U2 5
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0954-3007
EI 1476-5640
J9 EUR J CLIN NUTR
JI Eur. J. Clin. Nutr.
PD FEB
PY 2004
VL 58
IS 2
BP 195
EP 203
DI 10.1038/sj.ejcn.1601766
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 768CZ
UT WOS:000188511800001
PM 14749737
DA 2025-06-11
ER

PT J
AU Cazac, GD
   Lacatusu, CM
   Mihai, C
   Grigorescu, ED
   Onofriescu, A
   Mihai, BM
AF Cazac, Georgiana-Diana
   Lacatusu, Cristina-Mihaela
   Mihai, Catalina
   Grigorescu, Elena-Daniela
   Onofriescu, Alina
   Mihai, Bogdan-Mircea
TI New Insights into Non-Alcoholic Fatty Liver Disease and Coronary Artery
   Disease: The Liver-Heart Axis
SO LIFE-BASEL
LA English
DT Review
DE non-alcoholic fatty liver disease; coronary artery disease;
   cardiovascular risk; liver-heart axis
ID SERUM ALKALINE-PHOSPHATASE; STATES NATIONAL-HEALTH; METABOLIC SYNDROME;
   SUBCLINICAL ATHEROSCLEROSIS; CARDIOVASCULAR RISK; ENDOTHELIAL
   DYSFUNCTION; AMERICAN ASSOCIATION; HEPATIC STEATOSIS; PRACTICE GUIDANCE;
   PROGNOSTIC VALUE
AB Non-alcoholic fatty liver disease (NAFLD) represents the hepatic expression of the metabolic syndrome and is the most prevalent liver disease. NAFLD is associated with liver-related and extrahepatic morbi-mortality. Among extrahepatic complications, cardiovascular disease (CVD) is the primary cause of mortality in patients with NAFLD. The most frequent clinical expression of CVD is the coronary artery disease (CAD). Epidemiological data support a link between CAD and NAFLD, underlain by pathogenic factors, such as the exacerbation of insulin resistance, genetic phenotype, oxidative stress, atherogenic dyslipidemia, pro-inflammatory mediators, and gut microbiota. A thorough assessment of cardiovascular risk and identification of all forms of CVD, especially CAD, are needed in all patients with NAFLD regardless of their metabolic status. Therefore, this narrative review aims to examine the available data on CAD seen in patients with NAFLD, to outline the main directions undertaken by the CVD risk assessment and the multiple putative underlying mechanisms implicated in the relationship between CAD and NAFLD, and to raise awareness about this underestimated association between two major, frequent and severe diseases.
C1 [Cazac, Georgiana-Diana; Lacatusu, Cristina-Mihaela; Grigorescu, Elena-Daniela; Onofriescu, Alina; Mihai, Bogdan-Mircea] Grigore T Popa Univ Med & Pharm, Unit Diabet Nutr & Metab Dis, Iasi 700115, Romania.
   [Cazac, Georgiana-Diana; Lacatusu, Cristina-Mihaela; Onofriescu, Alina; Mihai, Bogdan-Mircea] St Spiridon Cty Clin Emergency Hosp, Clin Ctr Diabet Nutr & Metab Dis, Iasi 700111, Romania.
   [Mihai, Catalina] Sf Spiridon Emergency Hosp, Inst Gastroenterol & Hepatol, Iasi 700111, Romania.
   [Mihai, Catalina] Grigore T Popa Univ Med & Pharm, Unit Med Semiol & Gastroenterol, Iasi 700115, Romania.
C3 Grigore T Popa University of Medicine & Pharmacy; Grigore T Popa
   University of Medicine & Pharmacy; Grigore T Popa University of Medicine
   & Pharmacy; Grigore T Popa University of Medicine & Pharmacy
RP Lacatusu, CM; Grigorescu, ED (corresponding author), Grigore T Popa Univ Med & Pharm, Unit Diabet Nutr & Metab Dis, Iasi 700115, Romania.; Lacatusu, CM (corresponding author), St Spiridon Cty Clin Emergency Hosp, Clin Ctr Diabet Nutr & Metab Dis, Iasi 700111, Romania.
EM cristina.lacatusu@umfiasi.ro; elena-daniela-gh-grigorescu@umfiasi.ro
RI Mihai, Bogdan-Mircea/GMX-0613-2022; Onofriescu, Alina/IAQ-3459-2023;
   Grigorescu, Elena-Daniela/IAP-0871-2023; Mihai, Catalina/AAV-5234-2020;
   Cazac-Panaite, Georgiana-Diana/GQA-5703-2022; Lacatusu, Cristina
   Mihaela/AAE-5515-2022
OI Mihai, Catalina/0000-0001-9375-9224; Cazac-Panaite,
   Georgiana-Diana/0000-0002-6993-5491; Mihai, Bogdan/0000-0003-0413-026X;
   Lacatusu, Cristina Mihaela/0000-0002-9012-5901; GRIGORESCU,
   ELENA-DANIELA/0000-0002-7721-554X
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NR 172
TC 21
Z9 23
U1 0
U2 26
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2075-1729
J9 LIFE-BASEL
JI Life-Basel
PD AUG
PY 2022
VL 12
IS 8
AR 1189
DI 10.3390/life12081189
PG 25
WC Biology; Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics; Microbiology
GA 4C6EK
UT WOS:000846543900001
PM 36013368
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Paik, SH
   Jang, S
   Joh, HK
   Lim, CS
   Cho, B
   Kwon, O
   Jo, SJ
AF Paik, Seung Hwan
   Jang, Sihyeok
   Joh, Hee-Kyung
   Lim, Chun Soo
   Cho, BeLong
   Kwon, Ohsang
   Jo, Seong Jin
TI Association Between Premature Hair Greying and Metabolic Risk Factors: A
   Cross-sectional Study
SO ACTA DERMATO-VENEREOLOGICA
LA English
DT Article
DE hair greying; premature hair greying; metabolic syndrome; metabolic risk
   factors
ID CORONARY-ARTERY-DISEASE; OXIDATIVE STRESS; PREDICTOR; FOLLICLE; OBESITY;
   MARKER
AB The association of hair greying with metabolic syndrome is not well known, while association with obesity and coronary artery disease has been suggested. A cross-sectional study was conducted to identify an association between premature hair greying and metabolic risk factors. Of the 1,929 young healthy subjects (1,067 men and 862 women), 704 (36.4%) were categorized in the premature hair greying group. Waist circumference (means of non-premature hair greying vs. premature hair greying, 74.3 vs. 76.3 cm; p < 0.001), systolic (109.2 vs. 111.7 mmHg; p < 0.001) and diastolic (65.0 vs. 66.2 mmHg; p = 0.003) blood pressures, and fasting blood sugar (90.8 vs. 91.6 mg/dl; p = 0.013) were higher and serum high-density lipoprotein cholesterol (68.1 vs 65.4 mg/dl; p < 0.001) was lower in premature hair greying group. Multivariate logistic regression analysis showed that metabolic risk factors = 2 was independently associated with premature hair greying after controlling for confounding factors (odds ratio 1.725; p = 0.036). The present study revealed an association between premature hair greying and metabolic risk factors.
C1 [Paik, Seung Hwan; Jang, Sihyeok; Kwon, Ohsang; Jo, Seong Jin] Seoul Natl Univ, Coll Med, Dept Dermatol, 101 Daehangno, Seoul 03080, South Korea.
   [Joh, Hee-Kyung] Seoul Natl Univ, Coll Med, Dept Med, Seoul, South Korea.
   [Cho, BeLong] Seoul Natl Univ, Coll Med, Inst Aging, Seoul, South Korea.
   [Paik, Seung Hwan; Kwon, Ohsang; Jo, Seong Jin] Seoul Natl Univ, Inst Human Environm Interface Biol, Seoul, South Korea.
   [Cho, BeLong] Seoul Natl Univ, Adv Inst Convergence, Seoul, South Korea.
   [Paik, Seung Hwan; Kwon, Ohsang; Jo, Seong Jin] Seoul Natl Univ Hosp, Biomed Res Inst, Lab Cutaneous Aging & Hair Res, Seoul, South Korea.
   [Cho, BeLong] Seoul Natl Univ Hosp, Dept Family Med, Seoul, South Korea.
   [Cho, BeLong] Seoul Natl Univ Hosp, Hlth Promot Ctr, Seoul, South Korea.
   [Paik, Seung Hwan] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Dermatol, Seoul, South Korea.
   [Joh, Hee-Kyung] Seoul Natl Univ, Hlth Serv Ctr, Dept Family Med, Seoul, South Korea.
   [Lim, Chun Soo] Seoul Natl Univ, Boramae Med Ctr, Dept Internal Med, Seoul, South Korea.
C3 Seoul National University (SNU); Seoul National University (SNU); Seoul
   National University (SNU); Seoul National University (SNU); Seoul
   National University (SNU); Seoul National University (SNU); Seoul
   National University Hospital; Seoul National University (SNU); Seoul
   National University Hospital; Seoul National University (SNU); Seoul
   National University Hospital; University of Ulsan; Asan Medical Center;
   Seoul National University (SNU); Seoul National University (SNU); Seoul
   National University Hospital
RP Jo, SJ (corresponding author), Seoul Natl Univ, Coll Med, Dept Dermatol, 101 Daehangno, Seoul 03080, South Korea.
EM sj.jo@snu.ac.kr
RI Joh, Hee/J-5674-2012; Cho, Belong/GLU-3443-2022; KWON,
   OHSANG/J-2733-2012
OI Joh, Hee-Kyung/0000-0003-3854-7012; KWON, OHSANG/0000-0003-0464-5124;
   Jo, Seong Jin/0000-0002-2501-7672
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NR 20
TC 7
Z9 8
U1 2
U2 20
PU ACTA DERMATO-VENEREOLOGICA
PI UPPSALA
PA TRADGARDSGATAN 14, UPPSALA, SE-753 09, SWEDEN
SN 0001-5555
EI 1651-2057
J9 ACTA DERM-VENEREOL
JI Acta Derm.-Venereol.
PD SEP
PY 2018
VL 98
IS 8
BP 748
EP 752
DI 10.2340/00015555-2974
PG 5
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA GR3RF
UT WOS:000442511400005
PM 29799603
OA gold
DA 2025-06-11
ER

PT J
AU Lee, S
   Kim, DH
   Nam, HY
   Roh, YK
   Ju, SY
   Yoon, YJ
   Nam, GE
   Choi, JS
   Lee, JE
   Sang, JE
   Han, K
   Park, YG
AF Lee, Sangsu
   Kim, Do Hoon
   Nam, Hyo Yun
   Roh, Yong-Kyun
   Ju, Sang-Yhun
   Yoon, Yeo-Joon
   Nam, Ga-Eun
   Choi, Jun-Seok
   Lee, Jong-Eun
   Sang, Jung-Eun
   Han, Kyungdo
   Park, Yong-Gyu
TI Serum Gamma-Glutamyltransferase Levels are Associated With Concomitant
   Cardiovascular Risk Factors in Korean Hypertensive Patients A
   Nationwide Population-Based Study
SO MEDICINE
LA English
DT Article
ID YOUNG-ADULTS CARDIA; NORMAL BLOOD-PRESSURE; OXIDATIVE STRESS; METABOLIC
   SYNDROME; COHORT; GLUTAMYLTRANSFERASE; MICROALBUMINURIA;
   PREHYPERTENSION; TRANSPEPTIDASE; METAANALYSIS
AB Previous studies suggested that serum gamma-glutamyltransferase (GGT) levels were associated with the prevalence of cardiovascular disease (CVD) risk factors including hypertension, diabetes mellitus (DM), and metabolic syndrome (MetS) in the general population. We aimed to investigate the relationship between serum GGT levels and CVD risk factors in Korean hypertensive patients.
   This cross-sectional study was based on data from the Korea National Health and Nutrition Examination Survey (KNHANES) 2011 to 2012. The analysis included 1541 hypertensive participants. Study participants were divided into groups according to tertiles of serum GGT with cutoff points of 20 and 35 U/L.
   Serum GGT levels were positively associated with the components of MetS (P value < 0.05, except for systolic blood pressure and high-density lipoprotein cholesterol). After adjusting for possible confounders, serumGGT levels were associated with an increased risk of MetS, high waist circumference, high triglyceride level, fasting plasma glucose, DM, and the urinary albumin-to-creatinine ratio (P = 0.001).
   In hypertensive patients, serum GGT levels are positively associated with major cardiovascular risk factors such as MetS, DM, and urinary albumin excretion.
C1 [Lee, Sangsu; Kim, Do Hoon; Nam, Hyo Yun; Yoon, Yeo-Joon; Nam, Ga-Eun; Choi, Jun-Seok; Lee, Jong-Eun; Sang, Jung-Eun] Korea Univ, Coll Med, Dept Family Med, Seoul, South Korea.
   [Roh, Yong-Kyun] Hallym Univ, Coll Med, Dept Family Med, Chunchon, South Korea.
   [Ju, Sang-Yhun] Catholic Univ, Dept Biostat, Seoul, South Korea.
   [Han, Kyungdo; Park, Yong-Gyu] Catholic Univ, Coll Med, Dept Biostat, Seoul, South Korea.
   [Nam, Ga-Eun] Korea Univ, Dept Family Med, Ansan Hosp, Coll Med, 516 Gojan1-Dong, Ansan, Gyeonggi Do, South Korea.
C3 Korea University; Korea University Medicine (KU Medicine); Hallym
   University; Catholic University of Korea; Catholic University of Korea;
   Korea University; Korea University Medicine (KU Medicine)
RP Kim, DH (corresponding author), Korea Univ, Dept Family Med, Ansan Hosp, Coll Med, 516 Gojan1-Dong, Ansan, Gyeonggi Do, South Korea.
EM kmcfm@hanmail.net; yhn231@hanmail.net
RI Nam, Ga Eun/AAU-6055-2020; Lee, Jung-Seok/L-6826-2019; Ju,
   Sang/Q-2946-2019
OI Nam, Ga Eun/0000-0002-6739-9904; Ju, Sang Yhun/0000-0002-0553-7128;
   Park, Yong Gyu/0000-0002-8721-3230; Kim, Do Hoon/0000-0001-7421-4501
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NR 26
TC 1
Z9 3
U1 0
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD DEC
PY 2015
VL 94
IS 50
AR e2171
DI 10.1097/MD.0000000000002171
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA DD3XE
UT WOS:000369855900022
PM 26683926
OA Green Published, gold
DA 2025-06-11
ER

PT B
AU Cai, DS
   Liu, TW
AF Cai, Dongsheng
   Liu, Tiewen
GP Annals NY Acad Sci
TI Hypothalamic inflammation: a double-edged sword to nutritional diseases
SO YEAR IN DIABETES AND OBESITY
SE Annals of the New York Academy of Sciences-Series
LA English
DT Article; Book Chapter
DE hypothalamus; brain; inflammation; energy balance; metabolism; disease
ID NF-KAPPA-B; ENDOPLASMIC-RETICULUM STRESS; ACTIVATED PROTEIN-KINASE;
   DIET-INDUCED OBESITY; HEPATIC INSULIN-RESISTANCE; HIGH-FAT DIET;
   PATTERN-RECOGNITION RECEPTORS; IMPROVES GLUCOSE-HOMEOSTASIS; ENHANCED
   LEPTIN SENSITIVITY; MECHANISMS LINKING OBESITY
AB The hypothalamus is one of the master regulators of various physiological processes, including energy balance and nutrient metabolism. These regulatory functions are mediated by discrete hypothalamic regions that integrate metabolic sensing with neuroendocrine and neural controls of systemic physiology. Neurons and nonneuronal cells in these hypothalamic regions act supportively to execute metabolic regulations. Under conditions of brain and hypothalamic inflammation, which may result from overnutrition-induced intracellular stresses or disease-associated systemic inflammatory factors, extracellular and intracellular environments of hypothalamic cells are disrupted, leading to central metabolic dysregulations and various diseases. Recent research has begun to elucidate the effects of hypothalamic inflammation in causing diverse components of metabolic syndrome leading to diabetes and cardiovascular disease. These new understandings have provocatively expanded previous knowledge on the cachectic roles of brain inflammatory response in diseases, such as infections and cancers. This review describes the molecular and cellular characteristics of hypothalamic inflammation in metabolic syndrome and related diseases as opposed to cachectic diseases, and also discusses concepts and potential applications of inhibiting central/hypothalamic inflammation to treat nutritional diseases.
C1 [Cai, Dongsheng; Liu, Tiewen] Albert Einstein Coll Med, Dept Mol Pharmacol, Diabet Res Ctr, Bronx, NY 10461 USA.
C3 Montefiore Medical Center; Albert Einstein College of Medicine; Yeshiva
   University
RP Cai, DS (corresponding author), Albert Einstein Coll Med, Dept Mol Pharmacol, Diabet Res Ctr, 1300 Morris Pk Ave, Bronx, NY 10461 USA.
EM dongsheng.cai@einstein.yu.edu
RI Cai, Dongsheng/CAH-8271-2022
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NR 411
TC 131
Z9 146
U1 1
U2 20
PU BLACKWELL SCIENCE PUBL
PI OXFORD
PA OSNEY MEAD, OXFORD OX2 0EL, ENGLAND
BN 978-1-57331-847-1
J9 ANN NY ACAD SCI
JI Ann.NY Acad.Sci.
PY 2011
VL 1243
BP E1
EP E39
DI 10.1111/j.1749-6632.2011.06388.x
PG 39
WC Endocrinology & Metabolism; Multidisciplinary Sciences
WE Book Citation Index – Science (BKCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Science & Technology - Other Topics
GA BZG28
UT WOS:000301504400001
PM 22417140
OA hybrid, Green Accepted
DA 2025-06-11
ER

PT J
AU Hu, MX
   Lamers, F
   de Geus, EJC
   Penninx, BWJH
AF Hu, Mandy Xian
   Lamers, Femke
   de Geus, Eco J. C.
   Penninx, Brenda W. J. H.
TI Influences of lifestyle factors on cardiac autonomic nervous system
   activity over time
SO PREVENTIVE MEDICINE
LA English
DT Article
DE Autonomic nervous system; Lifestyle; Physical activity; Alcohol use;
   Smoking
ID HEART-RATE-VARIABILITY; AMBULATORY BLOOD-PRESSURE; CIGARETTE-SMOKING;
   PHYSICAL-ACTIVITY; METABOLIC SYNDROME; ALCOHOL-CONSUMPTION; RISK-FACTOR;
   SHORT-TERM; EXERCISE; DEPRESSION
AB Physical activity, alcohol use and smoking might affect cardiovascular disease through modifying autonomic nervous system (ANS) activity. We investigated: 1) whether there are consistent relationships between lifestyle factors and cardiac ANS activity over time, and 2) whether 2-year changes in lifestyle factors relate to 2-year changes in cardiac activity. Baseline (n = 2618) and 2-year follow-up (n = 2010) data of the Netherlands Study of Depression and Anxiety was combined. Baseline data was collected in the Netherlands from 2004-2007. Lifestyle factors were habitual physical activity, frequency of sport activities, alcohol use, and smoking. Indicators of cardiac activity were heart rate (HR), respiratory sinus arrhythmia (RSA) and pre-ejection period (PEP) (100 min of registration). The results showed that high physical activity (-1.8 beats/min compared to low activity), high frequency of sport activities ('couple of times/week': -2.5 beats/min compared to 'almost never') and mild/moderate alcohol use (-1.2 beats/min compared to non-drinking) were related to low HR. Heavy smoking was related to high HR (> 30 cigarettes/day: +5.1 beats/min compared to non- smoking). High frequency of sport activities was associated with high RSA ('couple of times/week': +1.7 ms compared to 'almost never') and moderate smoking with longer PEP (11-20 cigarettes/day: +2.8 ms compared to non-smoking). Associations were consistent across waves. Furthermore, 2-year change in frequency of sport activities and number of smoked cigarettes/day was accompanied by 2-year change in HR (beta = -0.076 and beta = 0.101, respectively) and RSA (beta = 0.046 and beta = -0.040, respectively). Our findings support consistent effects of lifestyle on HR and parasympathetic activity in the expected direction. Cardiac autonomic dysregulation may be partly mediating the relationship between lifestyle and subsequent cardiovascular health. (C) 2016 Elsevier Inc. All rights reserved.
C1 [Hu, Mandy Xian; Lamers, Femke; Penninx, Brenda W. J. H.] Vrije Univ Amsterdam, Med Ctr, Dept Psychiat, Amsterdam, Netherlands.
   [Hu, Mandy Xian; Lamers, Femke; Penninx, Brenda W. J. H.] Vrije Univ Amsterdam, Med Ctr, EMGO Inst Hlth & Care Res, Amsterdam, Netherlands.
   [de Geus, Eco J. C.] Vrije Univ Amsterdam, Dept Biol Psychol, Amsterdam, Netherlands.
   [de Geus, Eco J. C.] Vrije Univ Amsterdam, EMGO Inst Hlth & Care Res, Amsterdam, Netherlands.
C3 Vrije Universiteit Amsterdam; Vrije Universiteit Amsterdam; Vrije
   Universiteit Amsterdam; Vrije Universiteit Amsterdam
RP Hu, MX (corresponding author), AJ Ernststr 1187, NL-1081 HL Amsterdam, Netherlands.
EM m.hu@ggzingeest.nl
RI Penninx, Brenda/S-7627-2017; Lamers, Femke/G-5161-2012; de Geus,
   Eco/M-9318-2015
OI de Geus, Eco/0000-0001-6022-2666; Hu, Mandy Xian/0000-0002-4496-8772;
   Lamers, Femke/0000-0003-4344-5766
FU Geestkracht program of the Netherlands Organisation for Health Research
   and Development [10000-1002]; VU University Medical Center, Leiden
   University Medical Center, University Medical Center Groningen; European
   Union Seventh Framework Programme(FP7) [PCIG12-GA-2012-334065]
FX The infrastructure for the NESDA study (www.nesda.nl) has been funded
   through the Geestkracht program of the Netherlands Organisation for
   Health Research and Development (Zon-Mw, grant number 10000-1002) and
   participating universities (VU University Medical Center, Leiden
   University Medical Center, University Medical Center Groningen). FL has
   received funding from the European Union Seventh Framework Programme
   (FP7/2007-2013) under grant agreement no: PCIG12-GA-2012-334065. BP has
   received-unrelated-grant funding from Jansen.
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NR 67
TC 24
Z9 27
U1 2
U2 24
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0091-7435
EI 1096-0260
J9 PREV MED
JI Prev. Med.
PD JAN
PY 2017
VL 94
BP 12
EP 19
DI 10.1016/j.ypmed.2016.11.003
PG 8
WC Public, Environmental & Occupational Health; Medicine, General &
   Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; General & Internal Medicine
GA EO0ER
UT WOS:000396371600003
PM 27836526
OA Green Published
DA 2025-06-11
ER

PT J
AU Tain, YL
   Lin, YJ
   Hsu, CN
AF Tain, You-Lin
   Lin, Ying-Jui
   Hsu, Chien-Ning
TI Breastfeeding and Future Cardiovascular, Kidney, and Metabolic Health-A
   Narrative Review
SO NUTRIENTS
LA English
DT Review
DE breastfeeding; lactation; developmental origins of health and disease
   (DOHaD); microbiota; kidney disease; cardiovascular disease; metabolic
   syndrome; milk composition
ID TAURINE SUPPLEMENTATION PREVENTS; MATERNAL NICOTINE EXPOSURE;
   HUMAN-MILK; OXIDATIVE STRESS; BLOOD-PRESSURE; UTEROPLACENTAL
   INSUFFICIENCY; PROGRAMMED HYPERTENSION; PROLACTIN INHIBITION; INSULIN
   SENSITIVITY; RENAL DYSFUNCTION
AB The benefits of breastfeeding for both mother and infant are generally recognized; however, the connections between breast milk, lactation, and long-term offspring health and disease remain incompletely understood. Cardiovascular-kidney-metabolic syndrome (CKMS) has become a major global public health challenge. Insufficient breast milk supply, combined with various early-life environmental factors, markedly increases the future risk of CKMS, as highlighted by the developmental origins of health and disease (DOHaD) concept. Given its richness in nutrients and bioactive components essential for infant health, this review focuses on reprogramming strategies involving breast milk to improve offspring's cardiovascular, kidney, and metabolic health. It also highlights recent experimental advances in understanding the mechanisms driving CKMS programming. Cumulatively, the evidence suggests that lactational impairment heightens the risk of CKMS development. In contrast, early interventions during the lactation period focused on animal models that leverage breast milk components in response to early-life cues show potential in improving cardiovascular, kidney, and metabolic outcomes-an area warranting further investigation and clinical translation.
C1 [Tain, You-Lin] Kaohsiung Chang Gung Mem Hosp, Div Pediat Nephrol, Kaohsiung 833, Taiwan.
   [Tain, You-Lin] Chang Gung Univ, Coll Med, Taoyuan 333, Taiwan.
   [Tain, You-Lin] Kaohsiung Municipal Tatung Hosp, Dept Pediat, Kaohsiung 801, Taiwan.
   [Lin, Ying-Jui] Kaohsiung Chang Gung Mem Hosp, Dept Pediat, Div Crit Care, Kaohsiung 833, Taiwan.
   [Lin, Ying-Jui] Chang Gung Univ, Coll Med, Kaohsiung 833, Taiwan.
   [Lin, Ying-Jui] Kaohsiung Chang Gung Mem Hosp, Dept Pediat, Div Cardiol, Kaohsiung 833, Taiwan.
   [Lin, Ying-Jui] Chang Gung Univ, Kaohsiung Chang Gung Mem Hosp, Dept Resp Therapy, Coll Med, Kaohsiung 833, Taiwan.
   [Lin, Ying-Jui] Cheng Shiu Univ, Dept Early Childhood Care & Educ, Kaohsiung 833, Taiwan.
   [Hsu, Chien-Ning] Kaohsiung Chang Gung Mem Hosp, Dept Pharm, Kaohsiung 833, Taiwan.
   [Hsu, Chien-Ning] Kaohsiung Med Univ, Sch Pharm, Kaohsiung 807, Taiwan.
C3 Chang Gung Memorial Hospital; Chang Gung University; Kaohsiung Medical
   University; Kaohsiung Municipal Ta-Tung Hospital; Chang Gung Memorial
   Hospital; Chang Gung University; Chang Gung Memorial Hospital; Chang
   Gung University; Chang Gung Memorial Hospital; Cheng Shiu University;
   Chang Gung Memorial Hospital; Kaohsiung Medical University
RP Hsu, CN (corresponding author), Kaohsiung Chang Gung Mem Hosp, Dept Pharm, Kaohsiung 833, Taiwan.; Hsu, CN (corresponding author), Kaohsiung Med Univ, Sch Pharm, Kaohsiung 807, Taiwan.
EM tainyl@cgmh.org.tw; rayray@cgmh.org.tw; cnhsu@cgmh.org.tw
RI Tain, You-Lin/H-2827-2019; Hsu, Chien-Ning/GLS-4014-2022
OI Hsu, Chien-Ning/0000-0001-7470-528X
FU National Science and Technology Council, Taiwan; Kaohsiung Chang Gung
   Memorial Hospital, Kaohsiung, Taiwan [CORPG8M0351]; 
   [113-2314-B-182A-118]
FX This work was supported by financial assistance from the National
   Science and Technology Council, Taiwan, under grant number
   113-2314-B-182A-118, and Kaohsiung Chang Gung Memorial Hospital,
   Kaohsiung, Taiwan, under grant number CORPG8M0351.
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NR 222
TC 0
Z9 0
U1 1
U2 1
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD MAR 12
PY 2025
VL 17
IS 6
AR 995
DI 10.3390/nu17060995
PG 23
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 0OU5Q
UT WOS:001452453500001
PM 40290039
OA gold
DA 2025-06-11
ER

PT J
AU Dunham-Snary, KJ
   Sandel, MW
   Westbrook, DG
   Ballinger, SW
AF Dunham-Snary, Kimberly J.
   Sandel, Michael W.
   Westbrook, David G.
   Ballinger, Scott W.
TI A method for assessing mitochondrial bioenergetics in whole white
   adipose tissues
SO REDOX BIOLOGY
LA English
DT Article
DE Mitochondrion; White adipose tissue; Bioenergetics
ID METABOLIC SYNDROME; ENDOCRINE ORGAN; CARDIOVASCULAR-DISEASE; OXIDATIVE
   STRESS; DAMAGE; OBESITY; RESPIRATION; DYSFUNCTION; ADIPOCYTES; DNA
AB Obesity is a primary risk factor for numerous metabolic diseases including metabolic syndrome, type II diabetes (T2DM), cardiovascular disease and cancer. Although classically viewed as a storage organ, the field of white adipose tissue biology is expanding to include the consideration of the tissue as an endocrine organ and major contributor to overall metabolism. Given its role in energy production, the mitochondrion has long been a focus of study in metabolic dysfunction and a link between the organelle and white adipose tissue function is likely. Herein, we present a novel method for assessing mitochondrial bioenergetics from whole white adipose tissue. This method requires minimal manipulation of tissue, and eliminates the need for cell isolation and culture. Additionally, this method overcomes some of the limitations to working with transformed and / or isolated primary cells and allows for results to be obtained more expediently. In addition to the novel method, we present a comprehensive statistical analysis of bioenergetic data as well as guidelines for outlier analysis. (C) 2014 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-SA license
C1 [Dunham-Snary, Kimberly J.; Westbrook, David G.; Ballinger, Scott W.] Univ Alabama Birmingham, Dept Pathol, Div Mol & Cellular Pathol, Birmingham, AL 35294 USA.
   [Sandel, Michael W.] Univ Alabama Birmingham, Dept Biostat, Sect Stat Genet, Birmingham, AL 35294 USA.
C3 University of Alabama System; University of Alabama Birmingham;
   University of Alabama System; University of Alabama Birmingham
RP Ballinger, SW (corresponding author), Univ Alabama Birmingham, Dept Pathol, Div Mol & Cellular Pathol, BMR2 530,1720 2nd Ave South, Birmingham, AL 35294 USA.
EM sballing@uab.edu
RI Dunham-Snary, Kimberly/O-4702-2018; Sandel, Michael/AAZ-2000-2020
OI Dunham-Snary, Kimberly/0000-0001-9760-342X; Sandel,
   Michael/0000-0001-9083-9202
FU NIH [HL94518, HL103859]; American Heart Association Predoctoral
   Fellowship [11PRE7650033]; NHLBI Post-Doctoral Training Grant
   [5T32HL072757]; American Heart Association (AHA) [11PRE7650033] Funding
   Source: American Heart Association (AHA)
FX This study was funded by NIH grants HL94518 (S.W.B.) and HL103859
   (S.W.B.), an American Heart Association Predoctoral Fellowship
   11PRE7650033 (K.J.D.) and NHLBI Post-Doctoral Training Grant
   5T32HL072757 (M.W.S.). The authors thank Dr. Doug Moellering and theUAB
   Diabetes Research Center Bioanalytical Redox Biology Core (P60
   DK079626).
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NR 32
TC 31
Z9 34
U1 0
U2 9
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 2213-2317
J9 REDOX BIOL
JI Redox Biol.
PY 2014
VL 2
BP 656
EP 660
DI 10.1016/j.redox.2014.04.005
PG 5
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA CD0MY
UT WOS:000350769600076
PM 24936439
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Min, BK
   Kang, HJ
   Choi, BJ
   Jeon, YH
   Cho, JY
   Lee, IK
   Kim, DW
AF Min, Byong-Keol
   Kang, Hyeon-Ji
   Choi, Byung-Jun
   Jeon, Yong Hyun
   Cho, Je-Yoel
   Lee, In-Kyu
   Kim, Dong Wook
TI Phenylbutyrate Ameliorates High-Fat Diet-Induced Obesity via Brown
   Adipose Tissue Activation
SO BIOLOGICAL & PHARMACEUTICAL BULLETIN
LA English
DT Article
DE phenylbutyrate; liver type phosphofructokinase; obesity; uncoupling
   protein 1; brown adipose tissue
ID 4-PHENYLBUTYRATE PROTECTS; SODIUM PHENYLBUTYRATE; STRESS; EXPRESSION;
   THERMOGENESIS; INHIBITION; REDUCTION; GENE
AB Obesity, which is characterized by an excessive accumulation of body fat, is one of the critical factors causing metabolic syndrome. Many studies have been performed to identify appropriate agents to control obesity, but toxicity remains a problem. Herein, we identified that phenylbutyrate (PBA), which has been used to treat urea cycle disorder with very low toxicity for a long time, efficiently inhibited high fat-induced body weight gain in a diet-induced obesity mouse model (DIO model). PBA treatment decreased body fat mass and increased lean composition. Moreover, PBA increased brown adipose tissue (BAT) activity by increasing glucose uptake, thereby improving glucose tolerance and insulin tolerance. Interestingly, PBA could induce the expression of liver type phosphofructokinase (PFKL), a key enzyme in the glycolytic pathway, and knocking down PFKL dramatically repressed the expression level of Uep1 as well as those of Prdm16, Cidea, Pgc1 alpha, and Ppar gamma, which are marker genes for BAT activation. These results strongly suggested that PBA could increase energy expenditure by increasing BAT activity via the induction of PFKL. Taken together, PBA could be used as a therapeutic agent for people with obesity to prevent the development of metabolic syndrome.
C1 [Min, Byong-Keol; Kang, Hyeon-Ji; Lee, In-Kyu] Kyungpook Natl Univ, Res Inst Aging & Metab, 80 Daehak Ro, Daegu 41566, South Korea.
   [Choi, Byung-Jun] Kyungpook Natl Univ, Grad Sch, Dept Biomed Sci, 80 Daehak Ro, Daegu 41566, South Korea.
   [Jeon, Yong Hyun] Daegu Gyeongbuk Med Innovat Fdn, Lab Anim Ctr, 88 Dongnae Ro, Daegu 41061, South Korea.
   [Cho, Je-Yoel; Kim, Dong Wook] Seoul Natl Univ, Coll Vet Med, Dept Biochem, 1 Gwanak Ro, Seoul 08826, South Korea.
   [Lee, In-Kyu] Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Internal Med, 130 Dongdeok Ro, Daegu 41944, South Korea.
   [Lee, In-Kyu; Kim, Dong Wook] Kyungpook Natl Univ Hosp, Leading Edge Res Ctr Drug Discovery & Dev Diabet, 807 Hoguk Ro, Daegu 41404, South Korea.
C3 Kyungpook National University (KNU); Kyungpook National University
   (KNU); Seoul National University (SNU); Kyungpook National University
   (KNU); Kyungpook National University Hospital (KNUH); Kyungpook National
   University (KNU); Kyungpook National University Hospital (KNUH)
RP Lee, IK (corresponding author), Kyungpook Natl Univ, Res Inst Aging & Metab, 80 Daehak Ro, Daegu 41566, South Korea.; Kim, DW (corresponding author), Seoul Natl Univ, Coll Vet Med, Dept Biochem, 1 Gwanak Ro, Seoul 08826, South Korea.; Lee, IK (corresponding author), Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Internal Med, 130 Dongdeok Ro, Daegu 41944, South Korea.; Lee, IK; Kim, DW (corresponding author), Kyungpook Natl Univ Hosp, Leading Edge Res Ctr Drug Discovery & Dev Diabet, 807 Hoguk Ro, Daegu 41404, South Korea.
EM leei@knu.ac.kr; bellocan@snu.ac.kr
RI Jeon, Yong/N-6910-2019; Lee, In-Kyu/AAR-6374-2021
OI Min, Byong-Keol/0000-0002-8454-8940
FU Basic Science Research Program through the National Research Foundation
   of Korea (NRF) - Ministry of Education [NRF-2014R1A1A2055894,
   2017R1D1A1B03030844, 2017R1D1A1B03028340]; Korea Health Technology R&D
   Project through the Korea Health Industry Development Institute (KHIDI)
   - Ministry of Health & Welfare, Republic of Korea [HI16C1501]; National
   Research Foundation (NRF) - Ministry of Science, ICT & Future Planning
   [2016M3A9B6026771, 2014M3A9D5A01073598]
FX This work was supported by the Basic Science Research Program through
   the National Research Foundation of Korea (NRF) funded by the Ministry
   of Education (NRF-2014R1A1A2055894, 2017R1D1A1B03030844, and
   2017R1D1A1B03028340), by a Grant from the Korea Health Technology R&D
   Project through the Korea Health Industry Development Institute (KHIDI),
   funded by the Ministry of Health & Welfare, Republic of Korea. (Grant
   Number: HI16C1501), and by the National Research Foundation (NRF) funded
   by the Ministry of Science, ICT & Future Planning (2016M3A9B6026771,
   2014M3A9D5A01073598).
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NR 24
TC 9
Z9 12
U1 0
U2 5
PU PHARMACEUTICAL SOC JAPAN
PI TOKYO
PA 2-12-15 SHIBUYA, SHIBUYA-KU, TOKYO, 150-0002, JAPAN
SN 0918-6158
J9 BIOL PHARM BULL
JI Biol. Pharm. Bull.
PD SEP
PY 2019
VL 42
IS 9
BP 1554
EP 1561
DI 10.1248/bpb.b19-00346
PG 8
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA IV2KW
UT WOS:000484107100016
PM 31474715
OA gold
DA 2025-06-11
ER

PT J
AU Bezek, S
   Ujházy, E
   Dubovicky, M
   Mach, M
AF Bezek, Stefan
   Ujhazy, Eduard
   Dubovicky, Michal
   Mach, Mojmir
TI Nongenomic memory of foetal history in chronic diseases development
SO NEUROENDOCRINOLOGY LETTERS
LA English
DT Review
DE fetal programming; chronic diseases; epigenetic; molecular and endocrine
   mechanisms; hypoxia
ID METABOLIC SYNDROME; LIFE-HISTORY; EVOLUTIONARY PERSPECTIVE;
   POSTNATAL-DEVELOPMENT; GROWTH-RETARDATION; ENDOCRINE PANCREAS; OXIDATIVE
   STRESS; ADULT DISEASES; LUNG-FUNCTION; EARLY ORIGINS
AB Foetal growth from conception to birth is a complex process predetermined by the genetic configuration of the foetus, the availability of nutrients and oxygen to the foetus, maternal nutrition and various growth factors and hormones of maternal, foetal and placental origin.
   Maintenance of the optimal foetal environment is the key factor of the future quality of life. Such conditions like inadequate nutrition and oxygen supply, infection, hypertension, gestational diabetes or drug abuse by the mother, expose the foetus to nonphysiological environment. In conditions of severe intrauterine deprivation, there is a potential loss of structural units within the developing organ systems affecting their functionality and efficiency. Extensive human epidemiologic and animal model data indicate that during critical periods of prenatal and postnatal mammalian development, nutrition and other environmental stimuli influence developmental pathways and thereby induce permanent changes in metabolism and chronic disease susceptibility.
   The studies reviewed in this article show how environmental factors influence a diverse array of molecular mechanisms and consequently alter disease risk including diseases such as metabolic syndrome and cardiovascular diseases, insulin resistance and diabetes mellitus, neuropsychiatric disorders, osteoporosis, asthma and immune system diseases.
C1 [Bezek, Stefan] Slovak Acad Sci, Inst Expt Pharmacol, Lab Cell Cultures, Bratislava 84104, Slovakia.
C3 Slovak Academy of Sciences
RP Bezek, S (corresponding author), Slovak Acad Sci, Inst Expt Pharmacol, Lab Cell Cultures, Dubravska Cesta 9, Bratislava 84104, Slovakia.
EM stefan.bezek@savba.sk
RI , Mojino/GXZ-5248-2022
OI Dubovicky, Michal/0009-0001-5631-918X; Mach, Mojmir/0000-0001-6958-1024
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NR 59
TC 7
Z9 8
U1 0
U2 7
PU MAGHIRA & MAAS PUBLICATIONS
PI STOCKHOLM
PA PO BOX 26132, S-100 41 STOCKHOLM, SWEDEN
SN 0172-780X
J9 NEUROENDOCRINOL LETT
JI Neuroendocrinol. Lett.
PD OCT
PY 2008
VL 29
IS 5
BP 620
EP 626
PG 7
WC Endocrinology & Metabolism; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology
GA 381RI
UT WOS:000261553200004
PM 18987584
DA 2025-06-11
ER

PT J
AU Sovová, E
   Vrbková, J
   Stejskal, D
   Kamínek, M
   Metelková, I
   Budikova, M
   Kaletová, M
   Sova, M
   Sovová, M
AF Sovova, E.
   Vrbkova, J.
   Stejskal, D.
   Kaminek, M.
   Metelkova, I.
   Budikova, M.
   Kaletova, M.
   Sova, M.
   Sovova, M.
TI Pilot study of A-FABP levels as a predictive factor of SPECT results in
   asymptomatic relatives of patients with cardiovascular disease
SO BIOMARKERS IN MEDICINE
LA English
DT Article
DE A-FABP; cardiovascular prevention; first-degree relatives; stress-gated
   SPECT prediction
ID ACID-BINDING PROTEIN; CORONARY-ARTERY-DISEASE; COMPUTED-TOMOGRAPHY;
   RISK-FACTORS; METABOLIC SYNDROME; HEART-DISEASE; CALCIUM; ASSOCIATION;
   INDIVIDUALS; AP2
AB Background: A-FABP is a promising link between metabolic syndrome and atherosclerosis. It is not well known whether level of A-FABP predicts results of SPECT. Patients & methods: In 82 subjects (53 males) with a median age of 54 years, who were first-degree relatives of patients with cardiovascular disease, the following tests and examinations were performed: A-FABP, calcium score (CS) and SPECT. Results: Subjects with positive and negative SPECT results differed significantly in the noncategorized CS (p = 0.001), uric acid (p = 0.025) and the total cholesterol: high-density lipoprotein ratio (p = 0.043), but not in other parameters (including A-FABP). To predict SPECT results, the best model proved to be a logistic regression model with gender and noncategorized CS as predictors, with an area under the receiver operating characteristic curve of 0.89 (the sensitivity and specificity based on a CS cutoff of 11.1 were 77.78 and 75.34%, respectively). Conclusion: The serum level of A-FABP is not a predictor of a positive SPECT result.
C1 [Sovova, E.; Kaletova, M.] Palacky Univ, Fac Med & Dent, Dept Internal Med Cardiol 1, CR-77147 Olomouc, Czech Republic.
   [Sovova, E.; Kaminek, M.; Metelkova, I.; Budikova, M.; Kaletova, M.; Sova, M.] Univ Hosp Olomouc, Olomouc, Czech Republic.
   [Vrbkova, J.] Palacky Univ, Fac Sci, Dept Geoinformat, CR-77147 Olomouc, Czech Republic.
   [Stejskal, D.] Palacky Univ, Fac Med & Dent, Dept Med Chem & Biochem, CR-77147 Olomouc, Czech Republic.
   [Kaminek, M.; Metelkova, I.; Budikova, M.] Palacky Univ, Fac Med & Dent, Dept Nucl Med, CR-77147 Olomouc, Czech Republic.
   [Sova, M.] Palacky Univ, Fac Med & Dent, Dept Resp Med, CR-77147 Olomouc, Czech Republic.
   [Sovova, M.] Palacky Univ, Fac Med & Dent, CR-77147 Olomouc, Czech Republic.
C3 Palacky University Olomouc; University Hospital Olomouc; Palacky
   University Olomouc; Palacky University Olomouc; Palacky University
   Olomouc; Palacky University Olomouc; Palacky University Olomouc
RP Sova, M (corresponding author), Palacky Univ, Fac Med & Dent, Dept Resp Med, CR-77147 Olomouc, Czech Republic.
EM milan.sova@fnol.cz
RI Sova, Milan/AAH-3802-2020; Budíková, Marie/AAF-5455-2019; Stejskal,
   David/D-6125-2018
OI Stejskal, David/0000-0003-1204-0395
FU Operational Program Education for Competitiveness - European Social Fund
   of the Ministry of Education, Youth and Sports of the Czech Republic
   [CZ.1.07/2.3.00/20.0170]
FX The authors gratefully acknowledge the support by the Operational
   Program Education for Competitiveness - European Social Fund (project
   CZ.1.07/2.3.00/20.0170 of the Ministry of Education, Youth and Sports of
   the Czech Republic). The authors have no other relevant affiliations or
   financial involvement with any organization or entity with a financial
   interest in or financial conflict with the subject matter or materials
   discussed in the manuscript apart from those disclosed.
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NR 31
TC 0
Z9 0
U1 0
U2 1
PU FUTURE MEDICINE LTD
PI LONDON
PA UNITEC HOUSE, 3RD FLOOR, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON, N3
   1QB, ENGLAND
SN 1752-0363
EI 1752-0371
J9 BIOMARK MED
JI Biomark. Med.
PD JUN
PY 2014
VL 8
IS 5
BP 633
EP 640
DI 10.2217/BMM.13.160
PG 8
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA AO0QK
UT WOS:000341015700010
PM 25123032
DA 2025-06-11
ER

PT J
AU Armstrong, AW
   Zhao, Y
   Herrera, V
   Li, YF
   Bancroft, T
   Hull, M
   Altan, A
AF Armstrong, April W.
   Zhao, Yang
   Herrera, Vivian
   Li, Yunfeng
   Bancroft, Tim
   Hull, Michael
   Altan, Aylin
TI Drivers of Healthcare Costs Among the Costliest Patients With Psoriasis
   Over Three Years in a United States Health Plan
SO JOURNAL OF DRUGS IN DERMATOLOGY
LA English
DT Article
ID INCREASED PREVALENCE; ECONOMIC BURDEN; METABOLIC SYNDROME;
   DIABETES-MELLITUS; RISK; RECOMMENDATIONS; COMORBIDITIES; ASSOCIATION;
   DEPRESSION; MODERATE
AB Objective: To compare patients with psoriasis by cost level over 3 years.
   Methods: Psoriasis patients in a large US health plan in 2011-2013 were identified. Four groups were created by healthcare costs excluding biologics: patients having top 10% of costs in all 3 years (Top), top 10% in 2 of 3 years (High), bottom 90% in 2 of 3 years (Medium), and bottom 90% in all 3 years (Bottom). Comorbidities, utilization, and costs between groups were compared.
   Results: The study included 18,653 patients: 514 (3%), 805 (4%), 2,443 (13%), and 14,891 (80%) patients in the Top, High, Medium, and Bottom groups, respectively. Significantly more patients in the Top vs Bottom group had diabetes (31.1% vs 9.4%), cardiovascular disease (26.5% vs 4.3%), psoriatic arthritis (25.7% vs 10.7%), depression (27.8% vs 6.9%), and anxiety (22.0% vs 7.9%) in 2011 (all P<0.05). Patients in the Top group had more unique 2011 prescriptions (17.7 vs 6.6; P<0.001) than the Bottom group, but similar biologic use (22.4% vs 21.6%). Patients in the Top, High, Medium, and Bottom groups had mean 2011 total costs of $68,913, $40,575, $24,292, and $8,815, and contributed to 14%, 13%, 23%, and 51% of the overall costs, respectively. Mean total costs increased 14-18% over time for all groups. Although mean 2011 total costs for patients in the Top group were 78 times of those in the Bottom group, psoriasis-related costs were less disparate ($8,716 vs $4,541). Compared with patients in the Bottom group, those in the Top group were more likely to have any 2011 hospitalization (36.8% vs 2.6%; psoriasis-related: 11.1% vs 0.7%) or emergency visit (50.8% vs 20.8%; psoriasis-related: 3.9% vs 1.0%).
   Conclusion: The costliest patients with psoriasis had significantly higher prevalence of comorbidities, prescription fills, inpatient and emergency utilization, but not biologic medication use or biologic costs.
C1 [Armstrong, April W.] Univ Southern Calif, Los Angeles, CA USA.
   [Zhao, Yang; Herrera, Vivian; Li, Yunfeng] Novartis Pharmaceut, Hlth Econ & Outcomes Res, E Hanover, NJ USA.
   [Hull, Michael] Optum, Hlth Econ & Outcomes Res, Eden Prairie, MN 55344 USA.
   [Altan, Aylin] Optum Labs, Eden Prairie, MN USA.
C3 University of Southern California; Novartis; Novartis USA; Optum; Optum
RP Hull, M (corresponding author), Optum, Hlth Econ & Outcomes Res, Eden Prairie, MN 55344 USA.
EM michael.hull@optum.com
FU Novartis Pharmaceuticals Corporation (NPC)
FX This study was supported by Novartis Pharmaceuticals Corporation (NPC),
   Financial support was provided in the form of employment (Zhao, Li,
   Herrera); consultancies (Armstrong); and contract (Optum, Inc., by which
   authors Bancroft, Hull, and Altan, and medical writer C. Jennermann, are
   employed). Dr. Armstrong is employed by the University of Southern
   California, Los Angeles.
CR American Academy of Dermatology, 2015, CLIN GUID PSOR
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NR 32
TC 5
Z9 5
U1 0
U2 1
PU JOURNAL OF DRUGS IN DERMATOLOGY
PI NEW YORK
PA 377 PARK AVE SOUTH, 6TH FLOOR, NEW YORK, NY 10016 USA
SN 1545-9616
J9 J DRUGS DERMATOL
JI J. Drugs Dermatol.
PD JUL
PY 2017
VL 16
IS 7
BP 651
EP 658
PG 8
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA FA6HD
UT WOS:000405543000002
PM 28697216
DA 2025-06-11
ER

PT J
AU Gupte, AA
   Sabek, OM
   Fraga, D
   Minze, LJ
   Nishimoto, SK
   Liu, JZ
   Afshar, S
   Gaber, L
   Lyon, CJ
   Gaber, AO
   Hsueh, WA
AF Gupte, Anisha A.
   Sabek, Omaima M.
   Fraga, Daniel
   Minze, Laurie J.
   Nishimoto, Satoru K.
   Liu, Joey Z.
   Afshar, Solmaz
   Gaber, Lillian
   Lyon, Christopher J.
   Gaber, A. Osama
   Hsueh, Willa A.
TI Osteocalcin Protects Against Nonalcoholic Steatohepatitis in a Mouse
   Model of Metabolic Syndrome
SO ENDOCRINOLOGY
LA English
DT Article
ID FATTY LIVER-DISEASE; ENDOPLASMIC-RETICULUM STRESS; DIET-INDUCED OBESITY;
   ACCELERATED ATHEROSCLEROSIS; INTERMITTENT INJECTIONS; MACROPHAGE
   INFILTRATION; INSULIN SENSITIVITY; BONE PROTEIN; OSTEOPONTIN; TISSUE
AB Nonalcoholic fatty liver disease, particularly its more aggressive form, nonalcoholic steatohepatitis (NASH), is associated with hepatic insulin resistance. Osteocalcin, a protein secreted by osteoblast cells in bone, has recently emerged as an important metabolic regulator with insulin-sensitizing properties. In humans, osteocalcin levels are inversely associated with liver disease. We thus hypothesized that osteocalcin may attenuate NASH and examined the effects of osteocalcin treatment in middle-aged (12-mo-old) male Ldlr(-/-) mice, which were fed a Western-style high-fat, high-cholesterol diet for 12 weeks to induce metabolic syndrome and NASH. Mice were treated with osteocalcin (4.5 ng/h) or vehicle for the diet duration. Osteocalcin treatment not only protected against Western-style high-fat, high-cholesterol diet-induced insulin resistance but substantially reduced multiple NASH components, including steatosis, ballooning degeneration, and fibrosis, with an overall reduction in nonalcoholic fatty liver disease activity scores. Further, osteocalcin robustly reduced expression of proinflammatory and profibrotic genes (Cd68, Mcp1, Spp1, and Col1a2) in liver and suppressed inflammatory gene expression in white adipose tissue. In conclusion, these results suggest osteocalcin inhibits NASH development by targeting inflammatory and fibrotic processes.
C1 [Gupte, Anisha A.] Houston Methodist Res Inst, Bioenerget Program, Houston, TX USA.
   [Sabek, Omaima M.; Fraga, Daniel; Afshar, Solmaz; Gaber, A. Osama] Houston Methodist Hosp, Dept Surg, Houston, TX 77030 USA.
   [Minze, Laurie J.] Houston Methodist Res Inst, Immunobiol Res Ctr, Houston, TX 77030 USA.
   [Nishimoto, Satoru K.] Univ Tennessee, Hlth Sci Ctr, Dept Microbiol Immunol & Biochem, Memphis, TN 38163 USA.
   [Liu, Joey Z.; Lyon, Christopher J.; Hsueh, Willa A.] Methodist Diabet & Metab Inst, Houston Methodist Res Inst, Houston, TX 77030 USA.
   [Gaber, Lillian] Houston Methodist Hosp, Dept Pathol, Houston, TX 77030 USA.
   [Liu, Joey Z.; Hsueh, Willa A.] Ohio State Univ, Dept Med, Div Endocrinol Diabet & Metab, Columbus, OH 43210 USA.
C3 Houston Methodist; Houston Methodist; Houston Methodist; University of
   Tennessee System; University of Tennessee Health Science Center; Houston
   Methodist; Houston Methodist; University System of Ohio; Ohio State
   University
RP Hsueh, WA (corresponding author), Ohio State Univ, Wexner Med Ctr, Diabet Res Ctr, McCampbell Hall,1581 Dodd Dr, Columbus, OH 43210 USA.
EM willa.hsueh@osumc.edu
RI Xiao, Liuling/AFR-2506-2022; Gaber, Ahmed/GPW-7781-2022; Gupte,
   Anisha/D-6756-2015
OI sabek, omaima/0000-0003-0919-0093; Gupte, Anisha/0000-0002-5173-1773
FU Houston Methodist Research Institute; American Heart Association; Vivian
   Smith Foundation; MacDonald Foundation; Patel Family Foundation
FX This work was supported by grants from Houston Methodist Research
   Institute (O.M.S.), American Heart Association (A.A.G.), Vivian Smith
   Foundation (A.O.G.), and MacDonald Foundation and the Patel Family
   Foundation (W.A.H.).
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NR 38
TC 56
Z9 65
U1 1
U2 18
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0013-7227
EI 1945-7170
J9 ENDOCRINOLOGY
JI Endocrinology
PD DEC
PY 2014
VL 155
IS 12
BP 4697
EP 4705
DI 10.1210/en.2014-1430
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA AX0UN
UT WOS:000346668000011
PM 25279794
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Ament, Z
   Masoodi, M
   Griffin, JL
AF Ament, Zsuzsanna
   Masoodi, Mojgan
   Griffin, Julian L.
TI Applications of metabolomics for understanding the action of peroxisome
   proliferator-activated receptors (PPARs) in diabetes, obesity and cancer
SO GENOME MEDICINE
LA English
DT Review
DE metabolic syndrome; obesity; peroxisome proliferator-activated
   receptors; type II diabetes; functional genomics; the metabolic syndrome
ID GENE-EXPRESSION; SPECIES-DIFFERENCES; OXIDATIVE STRESS; ACID OXIDATION;
   GAMMA LIGANDS; FATTY-ACIDS; ALPHA; RAT; METABOLISM; DELTA
AB The peroxisome proliferator-activated receptors (PPARs) are a set of three nuclear hormone receptors that together play a key role in regulating metabolism, particularly the switch between the fed and fasted state and the metabolic pathways involving fatty-acid oxidation and lipid metabolism. In addition, they have a number of important developmental and regulatory roles outside metabolism. The PPARs are also potent targets for treating type II diabetes, dyslipidemia and obesity, although a number of individual agonists have also been linked to unwanted side effects, and there is a complex relationship between the PPARs and the development of cancer. This review examines the part that metabolomics, including lipidomics, has played in elucidating the roles PPARs have in regulating systemic metabolism, as well as their role in aspects of drug-induced cancer and xenobiotic metabolism. These studies have defined the role PPAR delta plays in regulating fatty-acid oxidation in adipose tissue and the interaction between aging and PPAR alpha in the liver. The potential translational benefits of these approaches include widening the role of PPAR agonists and improved monitoring of drug efficacy.
C1 [Ament, Zsuzsanna; Masoodi, Mojgan; Griffin, Julian L.] Med Res Council Human Nutr Res, Elsie Widdowson Lab, Cambridge CB1 9NL, England.
   [Ament, Zsuzsanna; Masoodi, Mojgan; Griffin, Julian L.] Univ Cambridge, Dept Biochem, Cambridge CB2 1GA, England.
C3 UK Research & Innovation (UKRI); Medical Research Council UK (MRC); MRC
   Human Nutrition Research; University of Cambridge; University of
   Cambridge
RP Griffin, JL (corresponding author), Med Res Council Human Nutr Res, Elsie Widdowson Lab, 120 Fulbourn Rd, Cambridge CB1 9NL, England.
EM jules.griffin@mrc-hnr.cam.ac.uk
RI Ament, Zsuzsanna/AGF-6631-2022; MASOODI, MOJGAN/P-1499-2019
OI Ament, Zsuzsanna/0000-0002-0316-4348; MASOODI,
   MOJGAN/0000-0001-9840-1731
FU Medical Research Council [UD99999906]; BBSRC [BB/H013539/1]; Wellcome
   Trust [093148/Z/10/Z]; EU (INHERITANCE); MRC ITTP training PhD
   studentship; BBSRC [BB/H013539/2, BB/H013539/1, BB/D524824/1] Funding
   Source: UKRI; MRC [MC_UP_A090_1006] Funding Source: UKRI; Wellcome Trust
   [093148/Z/10/Z] Funding Source: Wellcome Trust
FX JLG and MM are funded by the Medical Research Council (UD99999906). Work
   in the JLG lab is funded in addition by the BBSRC (BB/H013539/1), the
   Wellcome Trust (093148/Z/10/Z) and the EU (INHERITANCE). ZA is a
   recipient of an MRC ITTP training PhD studentship.
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NR 73
TC 45
Z9 54
U1 0
U2 54
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1756-994X
J9 GENOME MED
JI Genome Med.
PD APR 30
PY 2012
VL 4
AR 32
DI 10.1186/gm331
PG 12
WC Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Genetics & Heredity
GA 084WA
UT WOS:000314569200003
PM 22546357
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Goetz, SMM
   Lucas, T
   Granger, DA
AF Goetz, Stefan M. M.
   Lucas, Todd
   Granger, Douglas A.
TI Salivary uric acid dynamics are associated with stress response hormones
   among African American in an urban sample
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE Stress Reactivity; Uric Acid; Trier Social Stress Test; Health
   Disparities; Purinergic Stress Response; Multisystem Stress
ID SOCIAL EVALUATIVE THREAT; METABOLIC SYNDROME; OXIDATIVE STRESS;
   SEX-DIFFERENCES; BLOOD-PRESSURE; RISK-FACTORS; CORTISOL; REACTIVITY;
   HEALTH; DISCRIMINATION
AB Acute physiological responses to psychosocial stressors are a potential pathway underlying racial disparities in stress-related illnesses. Uric acid (UA) is a potent antioxidant that has been linked to disparities in stress-related illnesses, and recent research has shown that UA is responsive to acute social stress. However, an examination of the relationships between the purinergic system and other commonly measured stress systems is lacking. Here, we measure and characterize associations of salivary uric acid (sUA) with markers of hypothalamic-pituitaryadrenal (HPA) axis activation, sympathetic-adreno-medullar (SAM) axis activation, and acute inflammation. A community sample of 103 African Americans (33 male, 70 female) completed the Trier Social Stress Test to induce social-evaluative threat. Passive drool collected before, during, and after the stressor task provided salivary reactivity measures of UA (sUA), cortisol, dehydroepiandrosterone sulfate (DHEAS), salivary alpha amylase (sAA - a surrogate marker of SAM activity) and C-reactive protein (sCRP). Multiple regressions revealed that total activation of cortisol, DHEAS, and sCRP were each positively associated with higher total activation of sUA. Additionally, DHEAS reactivity was positively associated with sUA reactivity. Relationships between HPAaxis markers and sUA were especially observed among younger and male participants. Overall, findings suggest potential coordination of stress systems with sUA in response to acute stress, which may further the contributions of biological stress processes to racial health disparities.
C1 [Goetz, Stefan M. M.; Lucas, Todd] Michigan State Univ, Coll Human Med, Charles Stewart Mott Dept Publ Hlth, 200 East 1st St, Flint, MI 48502 USA.
   [Granger, Douglas A.] Univ Calif Irvine, Sch Social Ecol, Dept Psychol Sci, Irvine, CA 92697 USA.
   [Granger, Douglas A.] Univ Calif Irvine, Inst Interdisciplinary Salivary Biosci Res, 4201 SBSG, Irvine, CA 92697 USA.
   [Granger, Douglas A.] Johns Hopkins Univ, Dept Int Hlth, Sch Med, 615 North Wolfe St, Baltimore, MD 21205 USA.
C3 Michigan State University; Michigan State University College of Human
   Medicine; University of California System; University of California
   Irvine; University of California System; University of California
   Irvine; Johns Hopkins University
RP Lucas, T (corresponding author), Michigan State Univ, Coll Human Med, Charles Stewart Mott Dept Publ Hlth, 200 East 1st St, Flint, MI 48502 USA.
EM goetzste@msu.edu; lucastod@msu.edu; dagrange@uci.edu
FU National Heart, Lung, and Blood Institute [R21HL097191]
FX This research was supported by the National Heart, Lung, and Blood
   Institute (R21HL097191) awarded to Todd Lucas. The content is solely the
   responsibility of the authors and does not necessarily represent the
   official views of the National Heart, Lung, and Blood Institute. In the
   interest of full disclosure, DAG is founder and chief scientific and
   strategy advisor at Salimetrics LLC and Salivabio LLC and these
   relationships are managed by the policies of the committees on conflict
   of interest at the Johns Hopkins University School of Medicine and
   University of California at Irvine. We thank Mercedes Hendrickson,
   Nathan Weidner, Lenwood Hayman, Edyta Debowska, Kaitlyn Simmonds, Kevin
   Wynne, Rhiana Wegner, and the Clinical Research Center at Wayne State
   University for assistance with data collection. Finally, we appreciate
   biotechnical support with salivary assays provided by Carla Slike, Becky
   Zavacky, and Jessica Acevedo.
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NR 65
TC 1
Z9 1
U1 0
U2 0
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
EI 1873-3360
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD OCT
PY 2024
VL 168
AR 107120
DI 10.1016/j.psyneuen.2024.107120
EA JUL 2024
PG 8
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA YV5P5
UT WOS:001271276400001
PM 39002453
DA 2025-06-11
ER

PT J
AU Vetrani, C
   De Simone, G
   Saia, V
   Barrea, L
   Muscogiuri, G
   Graziadio, C
   De Bartolomeis, A
   Macchia, PE
   Colao, A
AF Vetrani, Claudia
   De Simone, Giuseppe
   Saia, Viviana
   Barrea, Luigi
   Muscogiuri, Giovanna
   Graziadio, Chiara
   De Bartolomeis, Andrea
   Macchia, Paolo E.
   Colao, Annamaria
TI Diet quality in patients with treatment-resistant schizophrenia: time
   for improving nutritional recommendations
SO MINERVA ENDOCRINOLOGY
LA English
DT Article; Early Access
DE Schizophrenia; treatment-resistant; Antipsychotic agents; Insulin
   resistance; Diabetes mellitus; type 2; Car- diovascular diseases
ID WEIGHT-GAIN; ANTIPSYCHOTIC-DRUGS; METABOLIC SYNDROME; RISK-FACTORS;
   FATTY-ACIDS; GUIDELINES; ADULTS; METAANALYSIS; DISEASE; OBESITY
AB BACKGROUND: Treatment-resistant schizophrenia (TRS) is a severe psychiatric disorder that is associated with a high level of psychotic symptoms and cognitive deficit as well as poor functioning, and an increased risk of mortality for cardiometabolic diseases. Some studies suggest that lifestyle, particularly diet, could represent a risk factor for obesity and its metabolic complications in these patients. METHODS: This cross-sectional study aimed to evaluate diet quality and eating habits in individuals with TRS. Seventeen participants (13M/4F aged 37.8 +/- 13 years) were recruited to assess dietary composition and food groups consumption by a 7days food record to assess. In addition, demographic and clinical data were collected. RESULTS: Most of the participants were overweight/obese (82%) and only 35% performed physical activity. As compared to nutritional recommendations, participants presented an insufficient intake of fiber (1 5.9 +/- 3.2 g/day), vitamins (thiamine, riboflavin, vitamin A, D, and E), minerals (calcium, magnesium, selenium, and iron), and polyunsaturated fatty acids (2.11 +/- 0.8%), likely triggered by the low consumption plant-based foods (legumes, fruit, vegetables, and nuts) and fish. Participants exceeded the intake of saturated fatty acids (11.6 +/- 3.4%) and cholesterol (242 +/- 124 mg/day), and simple sugars (15.2 +/- 3.9%) which were mainly related to greater consumption of red meat and processed meat, and sweet foods, respectively. CONCLUSIONS: Individuals with TRS presented low diet quality and did not comply with the nutritional recommendations. These results support the importance of including nutritional assessment in the management of individuals with TRS.
C1 [Vetrani, Claudia; Barrea, Luigi] Pegaso Telemat Univ, Dept Wellbeing Nutr & Sport, Naples, Italy.
   [Vetrani, Claudia; Barrea, Luigi; Muscogiuri, Giovanna; Graziadio, Chiara; Colao, Annamaria] Univ Naples Federico II, Ctr Italiano Cura & Benessere Paziente Obesita CIB, Naples, Italy.
   [De Simone, Giuseppe; Saia, Viviana; De Bartolomeis, Andrea] Univ Naples Federico II, Unit Treatment Resistant Psychosis, Dept Neurosci, Lab Mol & Translat Psychiat,Sect Psychiat, Naples, Italy.
   [Muscogiuri, Giovanna; Graziadio, Chiara; Macchia, Paolo E.; Colao, Annamaria] Univ Naples Federico II, Dept Clin Med & Surg, Unit Endocrinol, Naples, Italy.
   [Muscogiuri, Giovanna; De Bartolomeis, Andrea; Macchia, Paolo E.; Colao, Annamaria] Univ Naples Federico II, Educ Hlth & Sustainable Dev Program, Naples, Italy.
C3 Pegaso Online University; University of Naples Federico II; University
   of Naples Federico II; University of Naples Federico II; University of
   Naples Federico II
RP Vetrani, C (corresponding author), Univ Naples Federico II, Ctr Italiano Cura & Benessere Paziente Obesita CIB, Dept Humanities, Via Porzio, I-80143 Naples, Italy.
EM c.vetrani@libero.it
RI Macchia, Paolo Emidio/B-7391-2012; De Simone, Giuseppe/IQR-6459-2023;
   Claudia, Vetrani/D-3306-2018; Barrea, Luigi/K-6551-2016; Colao,
   Annamaria/A-7671-2011
FU European Union - Next Generation EU - PNRR M6C2 - Investment 2.1
   Enhancement and strengthening of biomedical research [C63C22001460007,
   NHS-PNRR-MR1-2022-12375654]
FX This study is part of the project "RISKMet" (CUP-code C63C22001460007)
   funded by the European Union - Next Generation EU - PNRR M6C2 -
   Investment 2.1 Enhancement and strengthening of biomedical research in
   the NHS-PNRR-MR1-2022-12375654.
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NR 63
TC 1
Z9 1
U1 2
U2 2
PU EDIZIONI MINERVA MEDICA
PI TURIN
PA CORSO BRAMANTE 83-85 INT JOURNALS DEPT., 10126 TURIN, ITALY
SN 2724-6507
EI 2724-6116
J9 MINERVA ENDOCRINOL
JI Minerva Endocrinol.
PD 2024 NOV 20
PY 2024
DI 10.23736/S2724-6507.24.04158-7
EA NOV 2024
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA M8H9S
UT WOS:001359900600001
PM 39565366
DA 2025-06-11
ER

PT J
AU Orakzai, RH
   Orakzal, SH
   Nasir, K
   Roguin, A
   Pimentel, I
   Carvalho, JAM
   Meneghello, R
   Blumenthal, RS
   Santos, RD
AF Orakzai, RH
   Orakzal, SH
   Nasir, K
   Roguin, A
   Pimentel, I
   Carvalho, JAM
   Meneghello, R
   Blumenthal, RS
   Santos, RD
TI Association of increased cardiorespiratory fitness with low risk for
   clustering of metabolic syndrome components in asymptomatic men
SO ARCHIVES OF MEDICAL RESEARCH
LA English
DT Article
DE metabolic syndrome; cardiorespiratory fitness; atherosclerosis; stress
   test
ID TIME PHYSICAL-ACTIVITY; DEPENDENT DIABETES-MELLITUS;
   CARDIOVASCULAR-DISEASE; INSULIN-RESISTANCE; MUSCLE TRIGLYCERIDE;
   SKELETAL-MUSCLE; AEROBIC FITNESS; EXERCISE; MORTALITY; CLASSIFICATION
AB Background. From a preventive aspect, it is especially important to investigate the lifestyle risk factors associated with cardiovascular disease (CVD). The purpose of this study was to determine the relationship of increasing metabolic syndrome (MS) components across increasing levels of estimated cardiorespiratory fitness (CRF) in asymptomatic young to middle-aged men.
   Methods. We studied 449 consecutive asymptomatic men (47 +/- 7 years) who underwent a maximal treadmill exercise test according to the Bruce protocol. Cardiorespiratory fitness (CRF) was divided into textiles based on metabolic equivalents (METs). The following MS components were studied: 1) waist circumference > 102 cm; 2) serum triglycerides >= 150 mg/dL; 3) HDL cholesterol levels of <40 rng/dL; 4) fasting blood glucose (FBG) >= 110 mg/dL or 5) blood pressure : >= 130/85 mmHg or treated hypertension. Multinomial logistic regression was used to investigate the relationship between clustering of MS components and CRF as determined by metabolic equivalents (METs). We used polytomous logistic regression to determine the likelihood of clustering of increasing components of metabolic syndrome with intermediate (2(nd) tertile) and low (1(st) tertile) levels of CRF as compared to those with highest levels of CRF (3(rd) tertile).
   Results. Overall in the study population, zero, 1, 2 and >= 3 (i.e., metabolic syndrome) risk factors for MS were observed in 29% (n = 129), 26% (n = 118), 22% (n = 98) and 23% (n = 104) men, respectively. The mean METS achieved in the study population was 10 +/- 2 (range 4-20). Nearly half (49%) of individuals with the highest levels of CRF had no MS risk factors whereas only 18% of those with low CRF (METS <9) had no MS risk factors. On the other end of the spectrum, the prevalence of MS (>= 3 MS risk factors) increased significantly across decreasing levels of CRF (6, 22, 33% p <0.0001 for trend). Multivariable polytomous logistic regression (adjusting for ace, smoking, cholesterollowering therapy) demonstrated that individuals with low CRF (1(st) tertile of METS) compared to those with highest CRF had 3.1- (p = 0.001) and 11.8- (p <0.0001) fold higher risk of having 2 and >= 3 MS components, respectively. Similar results were observed when the analyses was repeated adjusting for Framingham risk score.
   Conclusions. Asymptomatic men with low levels of CRF have a greater likelihood for clustering of MS components and thus are at higher CVD risk. Further studies are needed to define the risk of cardiovascular disease in patients with intermediate levels of CRF and address which treatment strategies are most important given an individual's risk profile. (C) 2006 IMSS. Published by Elsevier Inc.
C1 Univ Pittsburgh, Dept Med, Pittsburgh, PA USA.
   Johns Hopkins Univ, Sch Med, Ciccarone Prevent Cardiol Ctr, Baltimore, MD USA.
   Albert Einstein Hosp, Albert Einstein Prevent Med Ctr, Inst Ensino & Pesquisa Israelita, Sao Paulo, Brazil.
   Univ Sao Paulo, Med Sch Hosp, Inst Heart, Lipid Clin, Sao Paulo, Brazil.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE); University
   of Pittsburgh; Johns Hopkins University; Hospital Israelita Albert
   Einstein; Universidade de Sao Paulo
RP HCFMUSP, InCor, Unidade Clin Lipides, Av Dr Eneas C Aguiar 44,2 Andar Anexo 2, BR-05403000 Sao Paulo, Brazil.
EM rdsf@uol.com.br
RI Blumenthal, Roger/H-3223-2018; ROGUIN, Ariel/LNR-1950-2024; Nasir,
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NR 50
TC 21
Z9 25
U1 0
U2 4
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0188-4409
EI 1873-5487
J9 ARCH MED RES
JI Arch. Med. Res.
PD MAY
PY 2006
VL 37
IS 4
BP 522
EP 528
DI 10.1016/j.arcmed.2005.08.004
PG 7
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 037JK
UT WOS:000237142700017
PM 16624653
DA 2025-06-11
ER

PT J
AU Talebi, M
   Talebi, M
   Farkhondeh, T
   Simal-Gandara, J
   Kopustinskiene, DM
   Bernatoniene, J
   Pourbagher-Shahri, AM
   Samarghandian, S
AF Talebi, Marjan
   Talebi, Mohsen
   Farkhondeh, Tahereh
   Simal-Gandara, Jesus
   Kopustinskiene, Dalia M.
   Bernatoniene, Jurga
   Pourbagher-Shahri, Ali Mohammad
   Samarghandian, Saeed
TI Promising Protective Effects of Chrysin in Cardiometabolic Diseases
SO CURRENT DRUG TARGETS
LA English
DT Review
DE Chrysin; metabolic syndrome; diabetes mellitus; cardiovascular diseases;
   flavonoid; cardioprotective effects
ID METABOLIC SYNDROME; PHARMACOLOGICAL-ACTIVITIES; OROXYLUM-INDICUM;
   OXIDATIVE STRESS; FLAVONOIDS; RATS; SUPPRESSION; PROTEIN
AB Cardiometabolic diseases (CMD) have caused a great burden in terms of morbidity and mortality worldwide. The vicious cycle of CMD consists of type II diabetes, hypertension, dyslipidemia, obesity, and atherosclerosis. They have interlinked pathways, interacting and interconnecting with each other. The natural flavonoid chrysin has been shown to possess a broad spectrum of therapeutic activities for human health. Herein, we did an in-depth investigation of the novel mechanisms of chrysin's cardioprotection against cardiometabolic disorders. Studies have shown that chrysin protects the cardiovascular system by enhancing the intrinsic antioxidative defense system. This antioxidant property enhanced by chrysin protects against several risk factors of cardiometabolic disorders, including atherosclerosis, vascular inflammation and dysfunction, platelet aggregation, hypertension, dyslipidemia, cardiotoxicity, myocardial infarction, injury, and remodeling, diabetes-induced injuries, and obesity. Chrysin also exhibited anti-inflammatory mechanisms through inhibiting pro-inflammatory pathways, including NF-kappa B, MAPK, and PI3k/Akt. Furthermore, chrysin modulated NO, RAS, AGE/RAGE, and PPARs pathways which contributed to the risk factors of cardiometabolic disorders. Taken together, the mechanisms in which chrysin protects against cardiometabolic disorder are more than merely antioxidation and anti-inflammation in the cardiovascular system.
C1 [Talebi, Marjan] Shahid Beheshti Univ Med Sci, Sch Pharm, Dept Pharmacognosy, Tehran 1991953381, Iran.
   [Talebi, Mohsen] Univ Texas Arlington, Dept Chem & Biochem, Arlington, TX 76019 USA.
   [Talebi, Mohsen] Viatris Pharmaceut Inc, 3300 Res Plaza, San Antonio, TX 78235 USA.
   [Farkhondeh, Tahereh] Birjand Univ Med Sci, Cardiovasc Dis Res Ctr, Birjand, Iran.
   [Farkhondeh, Tahereh] Birjand Univ Med Sci, Fac Pharm, Birjand, Iran.
   [Simal-Gandara, Jesus] Univ Vigo, Fac Sci, Dept Analyt & Food Chem, Nutr & Bromatol Grp, Ourense Campus, E-32004 Orense, Spain.
   [Kopustinskiene, Dalia M.; Bernatoniene, Jurga] Lithuanian Univ Hlth Sci, Med Acad, Fac Pharm, Inst Pharmaceut Technol, Sukileliu Pr 13, LT-50161 Kaunas, Lithuania.
   [Bernatoniene, Jurga] Lithuanian Univ Hlth Sci, Med Acad, Fac Pharm, Dept Drug Technol & Social Pharm, Sukileliu Pr 13, LT-50161 Kaunas, Lithuania.
   [Pourbagher-Shahri, Ali Mohammad] Birjand Univ Med Sci, Med Toxicol & Drug Abuse Res Ctr MTDRC, Birjand, Iran.
   [Samarghandian, Saeed] Neyshabur Univ Med Sci, Noncommunicable Dis Res Ctr, Neyshabur, Iran.
C3 Shahid Beheshti University Medical Sciences; University of Texas System;
   University of Texas Arlington; Birjand University of Medical Sciences;
   Birjand University of Medical Sciences; Universidade de Vigo; Lithuanian
   University of Health Sciences; Lithuanian University of Health Sciences;
   Birjand University of Medical Sciences
RP Samarghandian, S (corresponding author), Neyshabur Univ Med Sci, Hlth Ageing Res Ctr, Neyshabur, Iran.
EM samarghandians1@nums.ac.ir
RI Pourbagher-Shahri, Ali M./Y-5021-2018; Bernatoniene,
   Jurga/JUV-0714-2023; Farkhondeh, Tahereh/Y-2083-2018; Simal-Gandara,
   Jesus/A-9533-2009; Talebi, Marjan/AAS-8240-2020
OI Simal-Gandara, Jesus/0000-0001-9215-9737; Talebi,
   Marjan/0000-0001-5513-3204
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NR 101
TC 8
Z9 8
U1 0
U2 14
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1389-4501
EI 1873-5592
J9 CURR DRUG TARGETS
JI Curr. Drug Targets
PY 2022
VL 23
IS 5
BP 458
EP 470
DI 10.2174/1389450122666211005113234
PG 13
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 2U8SJ
UT WOS:000823424300004
PM 34636295
DA 2025-06-11
ER

PT J
AU Azar, RR
   Sarkis, A
   Salameh, E
   Gannagé-Yared, MH
   Amm-Azar, M
   Badaoui, G
   Germanos, M
   Kassab, R
AF Azar, Rabih R.
   Sarkis, Antoine
   Salameh, Elie
   Gannage-Yared, Marie-Helene
   Amm-Azar, Mireille
   Badaoui, Georges
   Germanos, Mirna
   Kassab, Roland
TI Percutaneous coronary intervention increases leptin and decreases
   adiponectin levels
SO CLINICAL ENDOCRINOLOGY
LA English
DT Article
ID C-REACTIVE PROTEIN; METABOLIC SYNDROME; CARDIOVASCULAR-DISEASE;
   INSULIN-RESISTANCE; ADIPOSE-TISSUE; OXIDATIVE STRESS; OBESITY; RISK;
   INTERLEUKIN-6; ASSOCIATION
AB Objective The study was designed to examine the effect of percutaneous coronary intervention (PCI) on adiponectin and leptin levels. We have previously demonstrated that PCI triggers a systemic inflammatory response. We hypothesized that inflammation participates in the pathogenesis of diabetes mellitus and the metabolic syndrome by modulating levels of adiponectin and leptin.
   Design Prospective study in which inflammation was induced by PCI.
   Patients Forty-eight patients with stable coronary artery disease and without diabetes mellitus.
   Measurements High-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), leptin and adiponectin were measured at baseline and 48 h after the procedure.
   Results Following PCI, hs-CRP increased by 211%, IL-6 by 87% and leptin by 19%, while adiponectin decreased by 14% (P < 0.001 for all). The change in IL-6 correlated with that in hs-CRP (rho = 0.32; P = 0.027), as did the changes in IL-6 and leptin (rho = 0.31; P = 0.03). The change in adiponectin, however, did not correlate with the change in any of the other markers.
   Conclusion This study demonstrates that PCI affects the levels of adiponectin and leptin within 48 h. These effects may be secondary to the inflammatory response triggered by PCI.
C1 Hotel Dieu France Hosp, Div Cardiol, Beirut, Lebanon.
   Hotel Dieu France Hosp, Div Endocrinol, Beirut, Lebanon.
   Hotel Dieu France Hosp, Immunol Lab, Beirut, Lebanon.
   St Joseph Univ Sch Med, Beirut, Lebanon.
RP Azar, RR (corresponding author), Hotel Dieu France Hosp, Div Cardiol, Beirut, Lebanon.
EM razar@usj.edu.lb
RI Azar, Rabih/V-8962-2019
OI Holy Spirit University of Kaslik (USEK), FACULTY OF MEDICINE AND MEDICAL
   SCIENCESHoly Spirit University of Kaslik (USEK)/0000-0001-6734-4105;
   Gannage-Yared, Marie-Helene/0000-0001-8780-1254
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NR 39
TC 8
Z9 11
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0300-0664
EI 1365-2265
J9 CLIN ENDOCRINOL
JI Clin. Endocrinol.
PD DEC
PY 2006
VL 65
IS 6
BP 712
EP 716
DI 10.1111/j.1365-2265.2006.02654.x
PG 5
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 106OW
UT WOS:000242111400003
PM 17121520
DA 2025-06-11
ER

PT J
AU Na, GY
   Yoon, SR
   An, J
   Yeo, R
   Song, J
   Jo, MN
   Han, S
   Kim, OY
AF Na, Ga Yoon
   Yoon, So Ra
   An, Juhyun
   Yeo, Rimkyo
   Song, Juhyun
   Jo, Mi-Na
   Han, Seongho
   Kim, Oh Yoen
TI The relationship between circulating neutrophil gelatinase-associated
   lipocalin and early alteration of metabolic parameters is associated
   with dietary saturated fat intake in non- diabetic Korean women
SO ENDOCRINE JOURNAL
LA English
DT Article
DE Neutrophil gelatinase; associated lipocalin; Metabolic syndrome;
   Saturated fat intake; Inflammation; Oxidative stress
ID INSULIN-RESISTANCE; OXIDATIVE STRESS; CARDIOVASCULAR-DISEASE;
   GENE-EXPRESSION; IMMUNE-RESPONSE; INFLAMMATION; OBESITY; ENDOTOXEMIA;
   PROTEIN; MECHANISM
AB Circulating neutrophil gelatinase-associated lipocalin (NGAL) is associated with obesity-related metabolic disorders. This study investigated the relationship between serum NGAL and early alteration of metabolic parameters in non-diabetic Korean women, particularly with respect to saturated fat (SFA) intake. Anthropometric parameters, fasting glycemic status, and levels of lipids, oxidative stress/inflammatory markers, and NGAL were measured in 82 non-diabetic Korean women [Super-healthy group (n=57) with 0 metabolic syndrome risk factor (MetS RF) and MetS-risk group (n=25) with MetS RF >= 1]. Age, weight, waist circumference, blood pressure, fasting glucose, HbA1C, triglyceride, LDL and total-cholesterol, and NGAL levels were higher, and HDL-cholesterol was lower in the MetS-risk group than in the Super-healthy group. Age-adjusted serum NGAL levels were higher in the MetS-risk group than in the Super-healthy group. NGAL increased proportionally with increase in MetS RFs (p=0.038) and correlated positively with BMI, triglycerides, LDL-and total-cholesterol, interleukin-6, white blood cell count, and neutrophil%, and negatively with HDL-cholesterol and superoxide dismutase activity. Serum NGAL levels positively correlated with SFA intake before and after adjustment (age and BMI). Serum NGAL levels were higher in high-SFA consumers [>= 7g/day, >= 7% of total calorie intake (TCI)] than in low-SFA consumers (< 7g/day, < 7% of TCI). Serum NGAL levels were highest in the MetS-risk group consuming higher SFA and lowest in the Super-healthy group consuming lower SFA. However, serum NGAL did not significantly differ between the low-SFA consuming MetS-risk and Super-healthy groups. The relationship between circulating NGAL and early alteration of metabolic parameters is associated with dietary SFA intake in non-diabetic Korean women.
C1 [Na, Ga Yoon; Yoon, So Ra; An, Juhyun; Yeo, Rimkyo; Kim, Oh Yoen] Dong A Univ, Dept Food Sci & Nutr, Brain Busan Project 21, Busan 49315, South Korea.
   [Song, Juhyun] Chonnam Natl Univ, Ctr Creat Biomed Scientists, Dept Biomed Sci, Gwangju 61469, South Korea.
   [Jo, Mi-Na] Univ Suwon, Div Hotel & Tourism, Coll Econ & Business Adm, Suwon 18323, South Korea.
   [Han, Seongho] Dong A Univ, Coll Med, Dept Family Med, Busan 49315, South Korea.
C3 Dong A University; Chonnam National University; Suwon University; Dong A
   University
RP Kim, OY (corresponding author), Dong A Univ, Dept Food Sci & Nutr, 550beon Gil Hadan Dong 37, Busan 49315, South Korea.
EM oykim@dau.ac.kr
RI Song, Juhyun/AAH-3162-2020; Kim, Oh/AAA-6492-2022
OI Han, Seongho/0000-0002-6983-8683; Song, Juhyun/0000-0002-9165-8507
FU National Research Foundation of Korea - Korean Government
   [2016R1A2B4013627]
FX This study was supported by the National Research Foundation of Korea
   Grant funded by the Korean Government (2016R1A2B4013627).
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NR 45
TC 14
Z9 16
U1 0
U2 5
PU JAPAN ENDOCRINE SOC
PI KYOTO
PA 75  YANAGINOBANBA NISHIIRU-MASUYA-CHO, SANJOU-DORI, NAKAGYOU-KU, KYOTO,
   604-8111, JAPAN
SN 0918-8959
EI 1348-4540
J9 ENDOCR J
JI Endocr. J.
PY 2017
VL 64
IS 3
BP 303
EP 314
DI 10.1507/endocrj.EJ16-0233
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA ER1TK
UT WOS:000398576500007
PM 28049882
OA gold
DA 2025-06-11
ER

PT J
AU Risérus, U
   Sprecher, D
   Johnson, T
   Olson, E
   Hirschberg, S
   Liu, A
   Fang, Z
   Hegde, P
   Richards, D
   Sarov-Blat, L
   Strum, JC
   Basu, S
   Cheeseman, J
   Fielding, BA
   Humphreys, SM
   Danoff, T
   Moore, NR
   Murgatroyd, P
   O'Rahilly, S
   Sutton, P
   Willson, T
   Hassall, D
   Frayn, KN
   Karpe, F
AF Riserus, Ulf
   Sprecher, Dennis
   Johnson, Tony
   Olson, Eric
   Hirschberg, Sandra
   Liu, Aixue
   Fang, Zeke
   Hegde, Priti
   Richards, Duncan
   Sarov-Blat, Leli
   Strum, Jay C.
   Basu, Samar
   Cheeseman, Jane
   Fielding, Barbara A.
   Humphreys, Sandy M.
   Danoff, Theodore
   Moore, Niall R.
   Murgatroyd, Peter
   O'Rahilly, Stephen
   Sutton, Pauline
   Willson, Tim
   Hassall, David
   Frayn, Keith N.
   Karpe, Fredrik
TI Activation of peroxisome proliferator-activated receptor (PPAR)δ
   promotes reversal of multiple metabolic abnormalities, reduces oxidative
   stress, and increases fatly acid oxidation in moderately obese men
SO DIABETES
LA English
DT Article
ID C-III EXPRESSION; SKELETAL-MUSCLE; INSULIN-RESISTANCE; FATTY-ACID;
   ADIPOSE-TISSUE; LIVER FAT; HYPOLIPIDEMIC ACTION; BEZAFIBRATE THERAPY;
   LIPOPROTEIN-LIPASE; DIABETES-MELLITUS
AB OBJECTIEVE-Pharmacological use of peroxisome proliferator-activated receptor (PPAR)delta agonists and transgenic overexpression of PPAR delta in mice suggest amelioration of features of the metabolic syndrome through enhanced fat oxidation in skeletal muscle. We hypothesize a similar mechanism operates in humans.
   RESEARCH DESIGN AND METHODS-The PPAR delta agonist (10 mg o.d. GW501516), a comparator PPAR alpha agonist (20 mu g o.d. GW590735)), and placebo were given in a double-blind, randomized, three-parallel group, 2-week study to six healthy moderately overweight subjects in each group. Metabolic evaluation was made before and after treatment including liver fat quantification, fasting blood samples, a 6-h meal tolerance test with stable isotope fatty acids, skeletal muscle biopsy for gene expression, and urinary isoprostanes for global oxidative stress.
   RESULTS-Treatment with GW501516 showed statistically significant reductions in fasting plasma triglycerides (-30%), apolipoprotein B (-26%), LDL cholesterol (-23%), and insulin (-11%), whereas HDL cholesterol was unchanged. A 20% reduction in liver fat content (P < 0.05) and 30% reduction in urinary isoprostanes (P = 0.01) were also observed. Except for a lowering of triglycerides (-30%, P < 0.05), none of these changes were observed in response to GW590735. The relative proportion of exhaled CO, directly originating from the fat content of the meal was increased (P < 0.05) in response to GW501516, and skeletal muscle expression of carnitine palmitoyl-transferase 1b (CPT1b) was also significantly increased.
   CONCLUSIONS-The PPAR delta agonist GW501516 reverses multiple abnormalities associated with the metabolic syndrome without increasing oxidative stress. The effect is probably caused by increased fat oxidation in skeletal muscle.
C1 [Riserus, Ulf; Cheeseman, Jane; Fielding, Barbara A.; Humphreys, Sandy M.; Sutton, Pauline; Frayn, Keith N.; Karpe, Fredrik] Univ Oxford, Oxford Ctr Diabet Endocrinol & Metab, Oxford, England.
   [Sprecher, Dennis; Johnson, Tony; Olson, Eric; Hirschberg, Sandra; Liu, Aixue; Fang, Zeke; Danoff, Theodore] GlaxoSmithKline, Cardiovasc & Urogenital Ctr Excellence Drug Disco, Human Target Validat, King Of Prussia, PA USA.
   [Hegde, Priti; Sarov-Blat, Leli; Strum, Jay C.] GlaxoSmithKline, CPDM CVU Unit, King Of Prussia, PA USA.
   [Richards, Duncan] GlaxoSmithKline, Addenbrookes Ctr Clin Invest ACCT Unit, Cambridge, England.
   [Basu, Samar] Uppsala Univ, Dept Publ Hlth, Uppsala, Sweden.
   [Moore, Niall R.] Univ Oxford, Churchill Hosp, Dept Radiol, Oxford, England.
   [Murgatroyd, Peter] Addenbrookes Hosp, Wellcome Trust Clin Res Facil, Cambridge, England.
   [O'Rahilly, Stephen] Univ Cambridge, Dept Clin Biochem & Med, Cambridge, England.
   [Willson, Tim] GlaxoSmithKline, Res Triangle Pk, NC USA.
   [Hassall, David] GlaxoSmithKline, Stevenage, Herts, England.
C3 University of Oxford; GlaxoSmithKline; Glaxosmithkline USA;
   GlaxoSmithKline; Glaxosmithkline USA; GlaxoSmithKline; Glaxosmithkline
   United Kingdom; Uppsala University; University of Oxford; University of
   Cambridge; Cambridge University Hospitals NHS Foundation Trust;
   Addenbrooke's Hospital; University of Cambridge; GlaxoSmithKline;
   Glaxosmithkline USA; GlaxoSmithKline; Glaxosmithkline United Kingdom
RP Karpe, F (corresponding author), Churchill Hosp, Oxford OX3 7LJ, England.
EM fredrik.kaipe@ocdem.ox.ac.uk
RI O'Rahilly, Stephen/ABF-6509-2020; feinstein, doug/M-9414-2019
OI Richards, Duncan/0000-0002-8093-7084; Willson,
   Timothy/0000-0003-4181-8223; Frayn, Keith/0000-0001-7281-1863; Karpe,
   Fredrik/0000-0002-2751-1770; o'rahilly, stephen/0000-0003-2199-4449;
   Fielding, Barbara/0000-0001-7887-809X
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NR 48
TC 271
Z9 317
U1 0
U2 17
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0012-1797
EI 1939-327X
J9 DIABETES
JI Diabetes
PD FEB
PY 2008
VL 57
IS 2
BP 332
EP 339
DI 10.2337/db07-1318
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 259BP
UT WOS:000252914400007
PM 18024853
OA Bronze
DA 2025-06-11
ER

PT J
AU Tanaka, S
   Yamazaki, T
   Asano, S
   Mitsumoto, A
   Kobayashi, D
   Kudo, N
   Kawashima, Y
AF Tanaka, Shizuyo
   Yamazaki, Tohru
   Asano, Satoshi
   Mitsumoto, Atsushi
   Kobayashi, Daisuke
   Kudo, Naomi
   Kawashima, Yoichi
TI Increased Lipid Synthesis and Decreased β-Oxidation in the Liver of
   SHR/NDmcr-cp (cp/cp) Rats, an Animal Model of Metabolic
   Syndrome
SO LIPIDS
LA English
DT Article
DE Hepatic TAG accumulation; MUFA; De novo lipogenesis; beta-Oxidation;
   SHR/NDmcr-cp (cp/cp) rat
ID ENDOPLASMIC-RETICULUM STRESS; MONOUNSATURATED FATTY-ACIDS; HEPATIC
   STEATOSIS; TRIGLYCERIDE ACCUMULATION; TRANSCRIPTION FACTOR;
   INSULIN-RESISTANCE; UP-REGULATION; OBESE ZUCKER; ER STRESS; SREBP-1C
AB SHR/NDmcr-cp (cp/cp) rats (SHR/NDcp) are an animal model of metabolic syndrome. A previous study of ours revealed drastic increases in the mass of palmitic (16:0), oleic (18:1n-9), palmitoleic (16:1n-7), cis-vaccenic (18:1n-7) and 5,8,11-eicosatrienoic acids in the liver of SHR/NDcp. However, detailed information on the class of lipid accumulated and the mechanism responsible for the overproduction of the accumulated lipid in the liver was not obtained. This study aimed to characterize the class of lipid accumulated and to explore the mechanism underlying the lipid accumulation in the liver of SHR/NDcp, in comparison with SHR/NDmcr-cp (+/+) (lean hypertensive littermates of SHR/NDcp) and Wistar Kyoto rats. In the liver of SHR/NDcp, de novo synthesis of fatty acids (16:0, 18:1n-9 and 16:1n-7) and triacylglycerol (TAG) synthesis were up-regulated and fatty acid beta-oxidation was down-regulated. These perturbations of lipid metabolism caused fat accumulation in hepatocytes and accumulation of TAG, which were enriched with 16:0, 18:1n-9 and 16:1n-7, in the liver of SHR/NDcp. On the other hand, no changes were found in hepatic contents of diacylglycerol and unesterified fatty acid (FFA); among FFA, there were no differences in the hepatic concentrations of unesterified 16:0 and stearic acid between SHR/NDcp and two other groups of rats. Moreover, little change was brought about in the expression of genes responsive to endoplasmic reticulum stress in the liver of SHR/NDcp. These results may reinforce the pathophysiological role of stearoyl-CoA desaturase 1 and fatty acid elongase 6 in the liver of SHR/NDcp.
C1 [Tanaka, Shizuyo; Yamazaki, Tohru; Kobayashi, Daisuke; Kudo, Naomi; Kawashima, Yoichi] Josai Univ, Fac Pharmaceut Sci, Sakado, Saitama 3500295, Japan.
   [Asano, Satoshi] Int Univ Hlth & Welf, Dept Pharmaceut Sci, Ohtawara, Tochigi 3248501, Japan.
   [Mitsumoto, Atsushi] Josai Int Univ, Fac Pharmaceut Sci, Togane, Chiba 2838555, Japan.
C3 Josai University; International University of Health & Welfare
RP Kawashima, Y (corresponding author), Josai Univ, Fac Pharmaceut Sci, 1-1 Keyakidai, Sakado, Saitama 3500295, Japan.
EM ykawash@josai.ac.jp
FU Ministry of Education, Culture, Sports, Science and Technology of Japan
FX We thank Chiho Kojiguchi for her very helpful technical assistance. This
   work was supported by a Grant-in-Aid for Scientific Research from the
   Ministry of Education, Culture, Sports, Science and Technology of Japan.
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NR 68
TC 5
Z9 6
U1 0
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0024-4201
EI 1558-9307
J9 LIPIDS
JI Lipids
PD NOV
PY 2013
VL 48
IS 11
BP 1115
EP 1134
DI 10.1007/s11745-013-3839-6
PG 20
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA 239TD
UT WOS:000326047500006
PM 24045975
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Yagi, K
   Shimada, S
   Akiyama, Y
   Hatano, M
   Asano, D
   Ishikawa, Y
   Ueda, H
   Watanabe, S
   Akahoshi, K
   Ono, H
   Tanabe, M
   Tanaka, S
AF Yagi, Kohei
   Shimada, Shu
   Akiyama, Yoshimitsu
   Hatano, Megumi
   Asano, Daisuke
   Ishikawa, Yoshiya
   Ueda, Hiroki
   Watanabe, Shuichi
   Akahoshi, Keiichi
   Ono, Hiroaki
   Tanabe, Minoru
   Tanaka, Shinji
TI Loss of SFXN1 mitigates lipotoxicity and predicts poor outcome in
   non-viral hepatocellular carcinoma
SO SCIENTIFIC REPORTS
LA English
DT Article
ID STRESS
AB Hepatocellular carcinoma (HCC) imposes a huge global burden, arising from various etiological factors such as hepatitis virus infection and metabolic syndrome. While prophylactic vaccination and antiviral treatment have decreased the incidence of viral HCC, the growing prevalence of metabolic syndrome has led to an increase in non-viral HCC. To identify genes downregulated and specifically associated with unfavorable outcome in non-viral HCC cases, screening analysis was conducted using publically available transcriptome data. Among top 500 genes meeting the criteria, which were involved in lipid metabolism and mitochondrial function, a serine transporter located on inner mitochondrial membrane SFXN1 was highlighted. SFXN1 protein expression was significantly reduced in 33 of 105 HCC tissue samples, and correlated to recurrence-free and overall survival only in non-viral HCC. Human HCC cells with SFXN1 knockout (KO) displayed higher cell viability, lower fat intake and diminished reactive oxygen species (ROS) production in response to palmitate administration. In a subcutaneous transplantation mouse model, high-fat diet feeding attenuated tumorigenic potential in the control cells, but not in the SFXN1-KO cells. In summary, loss of SFXN1 expression suppresses lipid accumulation and ROS generation, preventing toxic effects from fat overload in non-viral HCC, and predicts clinical outcome of non-viral HCC patients.
C1 [Yagi, Kohei; Shimada, Shu; Akiyama, Yoshimitsu; Hatano, Megumi; Tanaka, Shinji] Tokyo Med & Dent Univ, Grad Sch Med, Dept Mol Oncol, 1-5-45 Yushima,Bunkyo Ku, Tokyo 1138519, Japan.
   [Yagi, Kohei; Asano, Daisuke; Ishikawa, Yoshiya; Ueda, Hiroki; Watanabe, Shuichi; Akahoshi, Keiichi; Ono, Hiroaki; Tanabe, Minoru; Tanaka, Shinji] Tokyo Med & Dent Univ, Grad Sch Med, Dept Hepatobiliary Pancreat Surg, Tokyo, Japan.
C3 Institute of Science Tokyo; Tokyo Medical & Dental University (TMDU);
   Institute of Science Tokyo; Tokyo Medical & Dental University (TMDU)
RP Shimada, S; Tanaka, S (corresponding author), Tokyo Med & Dent Univ, Grad Sch Med, Dept Mol Oncol, 1-5-45 Yushima,Bunkyo Ku, Tokyo 1138519, Japan.; Tanaka, S (corresponding author), Tokyo Med & Dent Univ, Grad Sch Med, Dept Hepatobiliary Pancreat Surg, Tokyo, Japan.
EM shimada.monc@tmd.ac.jp; tanaka.monc@tmd.ac.jp
FU Ministry of Education, Culture, Sports, Science and Technology of Japan
   [19H01055, 22K08864, 20K21627, 22K19554]; P-CREATE [JP19cm0106540]; AMED
   (Japan Agency for Medical Research and Development) [JP23fk0210102,
   JP23fk0210090, JP23fk0210106, JP23fk0210136]; Princess Takamatsu Cancer
   Research Fund; Grants-in-Aid for Scientific Research [22K19554,
   23K27670] Funding Source: KAKEN
FX This work was supported by Grants-in-Aid for Scientific Research (A,
   19H01055; C, 22K08864) and Challenging Research (Exploratory, 20K21627
   and 22K19554) from the Ministry of Education, Culture, Sports, Science
   and Technology of Japan; P-CREATE (JP19cm0106540) and Program for Basic
   and Clinical Research on Hepatitis (JP23fk0210102, JP23fk0210090,
   JP23fk0210106 and JP23fk0210136) from AMED (Japan Agency for Medical
   Research and Development); Research Grant from the Princess Takamatsu
   Cancer Research Fund.
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NR 24
TC 5
Z9 5
U1 1
U2 2
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD JUN 9
PY 2023
VL 13
IS 1
AR 9449
DI 10.1038/s41598-023-36660-w
PG 13
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA J0OQ8
UT WOS:001006690200055
PM 37296228
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Sabidó, E
   Wu, YB
   Bautista, L
   Porstmann, T
   Chang, CY
   Vitek, O
   Stoffel, M
   Aebersold, R
AF Sabido, Eduard
   Wu, Yibo
   Bautista, Lucia
   Porstmann, Thomas
   Chang, Ching-Yun
   Vitek, Olga
   Stoffel, Markus
   Aebersold, Ruedi
TI Targeted proteomics reveals strain-specific changes in the mouse insulin
   and central metabolic pathways after a sustained high-fat diet
SO MOLECULAR SYSTEMS BIOLOGY
LA English
DT Article
DE liver; metabolic syndrome; NAFLD; proteomics; SRM
ID NONALCOHOLIC STEATOHEPATITIS; LIVER-DISEASE; ENERGY-EXPENDITURE;
   MASS-SPECTROMETRY; OXIDATIVE STRESS; RESISTANCE; IDENTIFICATIONS;
   EXPRESSION; OBESITY
AB The metabolic syndrome is a collection of risk factors including obesity, insulin resistance and hepatic steatosis, which occur together and increase the risk of diseases such as diabetes, cardiovascular disease and cancer. In spite of intense research, the complex etiology of insulin resistance and its association with the accumulation of triacylglycerides in the liver and with hepatic steatosis remains not completely understood. Here, we performed quantitative measurements of 144 proteins involved in the insulin-signaling pathway and central metabolism in liver homogenates of two genetically well-defined mouse strains C57BL/6J and 129Sv that were subjected to a sustained high-fat diet. We used targeted mass spectrometry by selected reaction monitoring (SRM) to generate accurate and reproducible quantitation of the targeted proteins across 36 different samples (12 conditions and 3 biological replicates), generating one of the largest quantitative targeted proteomics data sets in mammalian tissues. Our results revealed rapid response to high-fat diet that diverged early in the feeding regimen, and evidenced a response to high-fat diet dominated by the activation of peroxisomal beta-oxidation in C57BL/6J and by lipogenesis in 129Sv mice.
C1 [Sabido, Eduard; Wu, Yibo; Bautista, Lucia; Porstmann, Thomas; Stoffel, Markus; Aebersold, Ruedi] ETH, Inst Mol Syst Biol, Dept Biol, CH-8093 Zurich, Switzerland.
   [Chang, Ching-Yun; Vitek, Olga] Purdue Univ, Dept Stat, W Lafayette, IN 47907 USA.
   [Vitek, Olga] Purdue Univ, Dept Comp Sci, W Lafayette, IN 47907 USA.
   [Aebersold, Ruedi] Univ Zurich, Fac Sci, Dept Sci, Zurich, Switzerland.
C3 Swiss Federal Institutes of Technology Domain; ETH Zurich; Purdue
   University System; Purdue University; Purdue University System; Purdue
   University; University of Zurich
RP Stoffel, M (corresponding author), ETH, Inst Mol Syst Biol, Dept Biol, Wolfgang Pauli Str 16, CH-8093 Zurich, Switzerland.
EM stoffel@imsb.biol.ethz.ch; aebersold@imsb.biol.ethz.ch
RI /AAK-8294-2020; Aebersold, Ruedi/ADH-8497-2022; Sabido,
   Eduard/F-7914-2015
OI Stoffel, Markus/0000-0003-1304-5817; Sabido, Eduard/0000-0001-6506-7714;
   Wu, Yibo/0000-0002-8256-3901
FU European Union via the ERC (European Research Council) [233226]; Swiss
   Initiative for Systems Biology (SystemsX); European Research Council
   (ERC) [233226] Funding Source: European Research Council (ERC); Div Of
   Biological Infrastructure; Direct For Biological Sciences [1054826]
   Funding Source: National Science Foundation
FX Support for this study was provided by the European Union via the ERC
   (European Research Council) advanced grant 'Proteomics v3.0' (grant#
   233226) to RA, and the LiverX program of the Swiss Initiative for
   Systems Biology (SystemsX) to ES, YWand LB.
CR Almind K, 2004, DIABETES, V53, P3274, DOI 10.2337/diabetes.53.12.3274
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NR 35
TC 28
Z9 31
U1 0
U2 21
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1744-4292
J9 MOL SYST BIOL
JI Mol. Syst. Biol.
PD JUL
PY 2013
VL 9
AR 681
DI 10.1038/msb.2013.36
PG 12
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 195QB
UT WOS:000322717600002
PM 23860498
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Che, Y
   Wang, ZP
   Yuan, Y
   Zhang, N
   Jin, YG
   Wan, CX
   Tang, QZ
AF Che, Yan
   Wang, Zhao-Peng
   Yuan, Yuan
   Zhang, Ning
   Jin, Ya-Ge
   Wan, Chun-Xia
   Tang, Qi-Zhu
TI Role of autophagy in a model of obesity: A long-term high fat diet
   induces cardiac dysfunction
SO MOLECULAR MEDICINE REPORTS
LA English
DT Article
DE high-fat diet; cardiac dysfunction; endoplasmic reticulum stress;
   autophagy; mitophagy
ID ENDOPLASMIC-RETICULUM; INSULIN-RESISTANCE; SIGNALING PATHWAY; OXIDATIVE
   STRESS; CELLS; MICE; LIPOTOXICITY; MITOCHONDRIA; HYPERTROPHY; EXPRESSION
AB Obesity may induce end-organ damage through metabolic syndrome, and autophagy serves a vital role in the pathogenesis of metabolic syndrome. The purpose of the present study was to define the roles of autophagy and mitophagy in high fat diet (HFD)-induced cardiomyopathy. Male, 8 week-old C57BL/6 mice were fed either a HFD (60% kcal) or a diet of normal chow (NC; 10% kcal) for 42 weeks. Glucose tolerance tests were performed during the feeding regimes. Blood samples were collected for assaying serum triglyceride with the glycerol-3-phosphate oxidase phenol and aminophenazone (PAP) method and total cholesterol was tested with the cholesterol oxidase-PAP method. Myocardial function was assessed using echocardiography and hemodynamic analyses. Western blot analysis was employed to evaluate endoplasmic reticulum stress (ERS), autophagy and mitochondrial function. Electron microscopy was used to assess the number of lipid droplets and the degree of autophagy within the myocardium. The body weight and adipose tissue weight of mice fed the HFD were increased compared with the NC mice. The serum levels of blood glucose, total cholesterol and triglyceride were significantly increased following 42 weeks of HFD feeding. The results of the glucose tolerance tests additionally demonstrated metabolic dysregulation in HFD mice. In addition, HFD mice exhibited hemodynamic and echocardiographic evidence of impaired diastolic and systolic function, including alterations in the cardiac output, end-diastolic pressure, end-diastolic volume and left ventricular relaxation time constant (tau) following HFD intake. Furthermore, a HFD resulted in increased ERS, and a downregulation of the autophagy and mitophagy level. The present study investigated cardiac function in obese HFD-fed mice. These results aid the pursuit of novel therapeutic targets to combat obesity-associated cardiomyopathy.
C1 [Che, Yan; Wang, Zhao-Peng; Yuan, Yuan; Zhang, Ning; Jin, Ya-Ge; Wan, Chun-Xia; Tang, Qi-Zhu] Wuhan Univ, Renmin Hosp, Dept Cardiol, 238 Jiefang Rd, Wuhan 430060, Hubei, Peoples R China.
   [Che, Yan; Wang, Zhao-Peng; Yuan, Yuan; Zhang, Ning; Jin, Ya-Ge; Wan, Chun-Xia; Tang, Qi-Zhu] Wuhan Univ, Cardiovasc Res Inst, Wuhan 430060, Hubei, Peoples R China.
   [Che, Yan; Wang, Zhao-Peng; Yuan, Yuan; Zhang, Ning; Jin, Ya-Ge; Wan, Chun-Xia; Tang, Qi-Zhu] Hubei Key Lab Cardiol, Wuhan 430060, Hubei, Peoples R China.
C3 Wuhan University; Wuhan University
RP Tang, QZ (corresponding author), Wuhan Univ, Renmin Hosp, Dept Cardiol, 238 Jiefang Rd, Wuhan 430060, Hubei, Peoples R China.
EM qztang@whu.edu.cn
FU National Natural Science Foundation of China [81270303, 81470516,
   81530012]
FX The present study was supported by the National Natural Science
   Foundation of China (grant nos. 81270303, 81470516 and 81530012).
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NR 54
TC 30
Z9 31
U1 0
U2 15
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1791-2997
EI 1791-3004
J9 MOL MED REP
JI Mol. Med. Rep.
PD SEP
PY 2018
VL 18
IS 3
BP 3251
EP 3261
DI 10.3892/mmr.2018.9301
PG 11
WC Oncology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Research & Experimental Medicine
GA GR7RK
UT WOS:000442890400083
PM 30066870
OA Green Published, Green Submitted, hybrid
DA 2025-06-11
ER

PT J
AU Hayden, MR
   Sowers, KM
   Pulakat, L
   Joginpally, T
   Krueger, B
   Whaley-Connell, A
   Sowers, JR
AF Hayden, Melvin R.
   Sowers, Kurt M.
   Pulakat, Lakshmi
   Joginpally, Tejaswini
   Krueger, Bennett
   Whaley-Connell, Adam
   Sowers, James R.
TI Possible Mechanisms of Local Tissue Renin-Angiotensin System Activation
   in the Cardiorenal Metabolic Syndrome and Type 2 Diabetes Mellitus
SO CARDIORENAL MEDICINE
LA English
DT Article
DE Adipose tissue; Insulin resistance; Mast cells; Reactive oxygen species;
   Redox stress; Renin-angiotensin system; Type 2 diabetes mellitus
ID OXIDATIVE STRESS; ADIPOSE-TISSUE; CONVERTING ENZYME; SKELETAL-MUSCLE;
   MAST-CELLS; BETA-CELL; HIP RAT; ALDOSTERONE SYSTEM; INSULIN-RESISTANCE;
   CHRONIC HYPOXIA
AB The role of local tissue renin-angiotensin system (tRAS) activation in the cardiorenal metabolic syndrome (CRS) and type 2 diabetes mellitus (T2DM) is not well understood. To this point, we posit that early redox stress-mediated injury to tissues and organs via accumulation of excessive reactive oxygen species (ROS) and associated wound healing responses might serve as a paradigm to better understand how tRAS is involved. There are at least five common categories responsible for generating ROS that may result in a positive feedback ROS-tRAS axis. These mechanisms include metabolic substrate excess, hormonal excess, hypoxia-ischemia/reperfusion, trauma, and inflammation. Because ROS are toxic to proteins, lipids, and nucleic acids they may be the primary instigator, serving as the injury nidus to initiate the wound healing process. Insulin resistance is central to the development of the CRS and T2DM, and there are now thought to be four major organ systems important in their development. In states of overnutrition and tRAS activation, adipose tissue, skeletal muscle (SkM), islet tissues, and liver (the quadrumvirate) are individually and synergistically related to the development of insulin resistance, CRS, and T2DM. The obesity epidemic is thought to be the driving force behind the CRS and T2DM, which results in the impairment of multiple end-organs, including the cardiovascular system, pancreas, kidney, retina, liver, adipose tissue, SkM, and nervous system. A better understanding of the complex mechanisms leading to local tRAS activation and increases in tissue ROS may lead to new therapies emphasizing global risk reduction of ROS resulting in decreased morbidity and mortality. Copyright (C) 2011 S. Karger AG, Basel
C1 [Hayden, Melvin R.; Pulakat, Lakshmi; Whaley-Connell, Adam; Sowers, James R.] Univ Missouri, Columbia Sch Med, Dept Internal Med, Columbia, MO 65211 USA.
   [Sowers, James R.] Univ Missouri, Columbia Sch Med, Dept Physiol & Pharmacol, Columbia, MO 65211 USA.
   [Hayden, Melvin R.; Pulakat, Lakshmi; Joginpally, Tejaswini; Krueger, Bennett; Whaley-Connell, Adam; Sowers, James R.] Diabetes Cardiovasc Ctr, Columbia, MO USA.
   [Pulakat, Lakshmi; Whaley-Connell, Adam; Sowers, James R.] Harry S Truman VA Med Ctr, Columbia, MO USA.
   [Sowers, Kurt M.] Kidney Specialists So Nevada, Henderson, NV USA.
C3 University of Missouri System; University of Missouri Columbia;
   University of Missouri System; University of Missouri Columbia; US
   Department of Veterans Affairs; Veterans Health Administration (VHA);
   Harry S. Truman Memorial Veterans' Hospital
RP Hayden, MR (corresponding author), D109 HSC Diabet Ctr, 1 Hosp Dr, Columbia, MO 65212 USA.
EM mrh29@usmo.com
FU NIH [R01 HL73101-01A1]; Veterans Affairs Merit System (NSF) [0018];
   Veterans Affairs Grants
FX This research was supported by NIH (R01 HL73101-01A1) and Veterans
   Affairs Merit System (0018; NSF LP) and Veterans Affairs Grants (J.R.S.
   and A.W.-C.).
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NR 117
TC 34
Z9 35
U1 0
U2 4
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1664-3828
EI 1664-5502
J9 CARDIORENAL MED
JI CardioRenal Med.
PY 2011
VL 1
IS 3
BP 193
EP 210
DI 10.1159/000329926
PG 18
WC Cardiac & Cardiovascular Systems; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Urology & Nephrology
GA 051ZM
UT WOS:000312167500007
PM 22096455
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Soukop, J
   Kazdová, L
   Hüttl, M
   Malínská, H
   Marková, I
   Oliyarnyk, O
   Miklánková, D
   Gurská, S
   Rácová, Z
   Poruba, M
   Vecera, R
AF Soukop, Jan
   Kazdova, Ludmila
   Huttl, Martina
   Malinska, Hana
   Markova, Irena
   Oliyarnyk, Olena
   Miklankova, Denisa
   Gurska, Sona
   Racova, Zuzana
   Poruba, Martin
   Vecera, Rostislav
TI Beneficial Effect of Fenofibrate in Combination with Silymarin on
   Parameters of Hereditary Hypertriglyceridemia-Induced Disorders in an
   Animal Model of Metabolic Syndrome
SO BIOMEDICINES
LA English
DT Article
DE fenofibrate; silymarin; triglycerides; metabolic syndrome; oxidative
   stress; insulin resistance; glycogen synthesis; reesterification of
   fatty acids
ID SPONTANEOUSLY HYPERTENSIVE-RATS; INSULIN-RESISTANCE; NONALCOHOLIC
   STEATOHEPATITIS; GLUCOSE-METABOLISM; OXIDATIVE STRESS; PPAR-ALPHA;
   PARAOXONASE; SENSITIVITY; THERAPY; REDUCE
AB Background: Hypertriglyceridemia has serious health risks such as cardiovascular disease, type 2 diabetes mellitus, nephropathy, and others. Fenofibrate is an effective hypolipidemic drug, but its benefits for ameliorating disorders associated with hypertriglyceridemia failed to be proven in clinical trials. Methods: To search for possible causes of this situation and possibilities of their favorable influence, we tested the effect of FF monotherapy and the combination of fenofibrate with silymarin on metabolic disorders in a unique model of hereditary hypertriglyceridemic rats (HHTg). Results: Fenofibrate treatment (100 mg/kg BW/day for four weeks) significantly decreased serum levels of triglyceride, (-77%) and free fatty acids (-29%), the hepatic accumulation of triglycerides, and the expression of genes encoding transcription factors involved in lipid metabolism (Srebf2, Nr1h4. Rxr alpha, and Slco1a1). In contrast, the hypertriglyceridemia-induced ectopic storage of lipids in muscles, the heart, and kidneys reduced glucose utilization in muscles and was not affected. In addition, fenofibrate reduced the activity of the antioxidant system, including Nrf2 expression (-35%) and increased lipoperoxidation in the liver and, to a lesser extent, in the kidneys and heart. Adding silymarin (micronized form, 600 mg/kg BW/day) to fenofibrate therapy increased the synthesis of glycogen in muscles, (+36%) and reduced hyperinsulinemia (-34%). In the liver, it increased the activity of the antioxidant system, including PON-1 activity and Nrf2 expression, and reduced the formation of lipoperoxides. The beneficial effect of combination therapy on the parameters of oxidative stress and lipoperoxidation was also observed, to a lesser extent, in the heart and kidneys. Conclusions: Our results suggest the potential beneficial use of the combination of FF with SLM in the treatment of hypertriglyceridemia-induced metabolic disorders.
C1 [Soukop, Jan; Racova, Zuzana; Poruba, Martin; Vecera, Rostislav] Palacky Univ Olomouc, Fac Med & Dent, Dept Pharmacol, Olomouc 77515, Czech Republic.
   [Kazdova, Ludmila; Huttl, Martina; Malinska, Hana; Markova, Irena; Oliyarnyk, Olena; Miklankova, Denisa] Inst Clin & Expt Med, Ctr Expt Med, Prague 14021, Czech Republic.
   [Gurska, Sona] Palacky Univ Olomouc, Inst Mol & Translat Med, Fac Med & Dent, Olomouc 77515, Czech Republic.
C3 Palacky University Olomouc; Institute for Clinical & Experimental
   Medicine (IKEM); Palacky University Olomouc
RP Poruba, M; Vecera, R (corresponding author), Palacky Univ Olomouc, Fac Med & Dent, Dept Pharmacol, Olomouc 77515, Czech Republic.
EM jan.soukop01@upol.cz; martin.poruba@upol.cz; rostislav.vecera@upol.cz
RI Oliyarnyk, Olena/Q-6380-2019
OI Poruba, Martin/0000-0003-1252-4971; SOUKOP, Jan/0000-0002-0930-4372;
   Malinska, Hana/0000-0002-9076-3399; Markova, Irena/0000-0002-4331-7636;
   Kazdova, Ludmila/0000-0003-0563-0186
FU Internal Grant Agency of Palacky University Olomouc; Czech Science
   Foundation;  [IGA_LF_2024_006];  [IN 00023001]
FX This study was supported by grant IGA_LF_2024_006 of the Internal Grant
   Agency of Palacky University Olomouc, a grant from the Czech Science
   Foundation and by the Ministry of Health of the Czech Republic under its
   program for the conceptual development of research organizations
   (Institute for Clinical and Experimental Medicine-IKEM, IN 00023001).
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NR 57
TC 0
Z9 0
U1 6
U2 6
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2227-9059
J9 BIOMEDICINES
JI Biomedicines
PD JAN
PY 2025
VL 13
IS 1
AR 212
DI 10.3390/biomedicines13010212
PG 21
WC Biochemistry & Molecular Biology; Medicine, Research & Experimental;
   Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Research & Experimental Medicine;
   Pharmacology & Pharmacy
GA T4H6R
UT WOS:001404641000001
PM 39857794
OA gold
DA 2025-06-11
ER

PT J
AU Villegas-Romero, M
   Castrejón-Téllez, V
   Pérez-Torres, I
   Rubio-Ruiz, ME
   Carreón-Torres, E
   Díaz-Díaz, E
   del Valle-Mondragón, L
   Guarner-Lans, V
AF Villegas-Romero, Mariana
   Castrejon-Tellez, Vicente
   Perez-Torres, Israel
   Esther Rubio-Ruiz, Maria
   Carreon-Torres, Elizabeth
   Diaz-Diaz, Eulises
   del Valle-Mondragon, Leonardo
   Guarner-Lans, Veronica
TI Short-Term Exposure to High Sucrose Levels near Weaning Has a Similar
   Long-Lasting Effect on Hypertension as a Long-Term Exposure in Rats
SO NUTRIENTS
LA English
DT Article
DE critical window; hypertension; sucrose; endothelial nitric oxide
   synthase; oxidative stress; fatty acids
ID NITRIC-OXIDE SYNTHASE; LOW-DENSITY-LIPOPROTEIN; ADULT-BLOOD PRESSURE;
   OXIDATIVE STRESS; SUPEROXIDE-DISMUTASE; ENDOTHELIAL FUNCTION; VASCULAR
   REACTIVITY; PROTEIN-SYNTHESIS; HIGH-CARBOHYDRATE; ARACHIDONIC-ACID
AB Adverse conditions during early developmental stages permanently modify the metabolic function of organisms through epigenetic changes. Exposure to high sugar diets during gestation and/or lactation affects susceptibility to metabolic syndrome or hypertension in adulthood. The effect of a high sugar diet for shorter time lapses remains unclear. Here we studied the effect of short-term sucrose ingestion near weaning (postnatal days 12 and 28) (STS) and its effect after long-term ingestion, for a period of seven months (LTS) in rats. Rats receiving sucrose for seven months develop metabolic syndrome (MS). The mechanisms underlying hypertension in this model and those that underlie the effects of short-term exposure have not been studied. We explore NO and endothelin-1 concentration, endothelial nitric oxide synthase (eNOS) expression, fatty acid participation and the involvement of oxidative stress (OS) after LTS and STS. Blood pressure increased to similar levels in adult rats that received sucrose during short- and long-term glucose exposure. The endothelin-1 concentration increased only in LTS rats. eNOS and SOD2 expression determined by Western blot and total antioxidant capacity were diminished in both groups. Saturated fatty acids and arachidonic acid were only decreased in LTS rats. In conclusion, a high-sugar diet during STS increases the hypertension predisposition in adulthood to as high a level as LTS, and the mechanisms involved have similarities (participation of OS and eNOS and SOD expression) and differences (fatty acids and arachidonic acid only participate in LTS and an elevated level of endothelin-1 was only found in LTS) in both conditions. Changes in the diet during short exposure times in early developmental stages have long-lasting effects in determining hypertension susceptibility.
C1 [Villegas-Romero, Mariana; Castrejon-Tellez, Vicente; Esther Rubio-Ruiz, Maria; Guarner-Lans, Veronica] Inst Nacl Cardiol Ignacio Chavez, Dept Physiol, Juan Badiano 1,Secc 16, Mexico City 14080, DF, Mexico.
   [Perez-Torres, Israel] Inst Nacl Cardiol Ignacio Chavez, Dept Pathol, Juan Badiano 1,Secc 16, Mexico City 14080, DF, Mexico.
   [Carreon-Torres, Elizabeth] Inst Nacl Cardiol Ignacio Chavez, Dept Mol Biol, Juan Badiano 1,Secc 16, Mexico City 14080, DF, Mexico.
   [Diaz-Diaz, Eulises] Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Reprod Biol, Vasco de Quiroga 15,Secc 16, Mexico City 14000, DF, Mexico.
   [del Valle-Mondragon, Leonardo] Inst Nacl Cardiol Ignacio Chavez, Dept Pharmacol, Juan Badiano 1,Secc 16, Mexico City 14080, DF, Mexico.
C3 National Institute of Cardiology - Mexico; National Institute of
   Cardiology - Mexico; National Institute of Cardiology - Mexico;
   Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran -
   Mexico; National Institute of Cardiology - Mexico
RP Guarner-Lans, V (corresponding author), Inst Nacl Cardiol Ignacio Chavez, Dept Physiol, Juan Badiano 1,Secc 16, Mexico City 14080, DF, Mexico.
EM mvromero21@gmail.com; vcastrejn@yahoo.com.mx; pertorisr@yahoo.com.mx;
   esther_rubio_ruiz@yahoo.com; qfbelizabethcm@yahoo.es;
   eulisesd@yahoo.com; leonardodvm65@hotmail.com; gualanv@yahoo.com
RI Guarner-Lans, Verónica/AFW-3723-2022; Pérez Torres, Israel/AAE-2579-2022
OI Carreon-Torres, Elizabeth/0000-0003-3600-249X; Guarner-Lans,
   Veronica/0000-0002-2655-7590; del Valle-Mondragon,
   Leonardo/0000-0002-2999-1050; Rubio-Ruiz, Maria
   Esther/0000-0002-8844-2078; Perez-Torres, Israel/0000-0001-6510-2954;
   Castrejon Tellez, Vicente/0000-0002-8518-6961
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NR 99
TC 15
Z9 16
U1 1
U2 1
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JUN
PY 2018
VL 10
IS 6
AR 728
DI 10.3390/nu10060728
PG 20
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA GK8VC
UT WOS:000436507200072
PM 29882756
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Zorach, B
   Shaw, PW
   Bourque, J
   Kuruvilla, S
   Balfour, PC
   Yang, Y
   Mathew, R
   Pan, J
   Gonzalez, JA
   Taylor, AM
   Meyer, CH
   Epstein, FH
   Kramer, CM
   Salerno, M
AF Zorach, Benjamin
   Shaw, Peter W.
   Bourque, Jamieson
   Kuruvilla, Sujith
   Balfour, Pelbreton C.
   Yang, Yang
   Mathew, Roshin
   Pan, Jonathan
   Gonzalez, Jorge A.
   Taylor, Angela M.
   Meyer, Craig H.
   Epstein, Frederick H.
   Kramer, Christopher M.
   Salerno, Michael
TI Quantitative cardiovascular magnetic resonance perfusion imaging
   identifies reduced flow reserve in microvascular coronary artery disease
SO JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE
LA English
DT Article
DE Cardiovascular magnetic resonance; Microvascular disease; Myocardial
   perfusion reserve; Non-obstructive coronary artery disease; Angina;
   Women; Diabetes; Metabolic syndrome
ID MYOCARDIAL-PERFUSION; HEART-DISEASE; CHEST-PAIN; DYSFUNCTION; WOMEN;
   ANGIOGRAPHY; ASSOCIATION; ISCHEMIA; UPDATE; RISK
AB Background: Preliminary semi-quantitative cardiovascular magnetic resonance (CMR) perfusion studies have demonstrated reduced myocardial perfusion reserve (MPR) in patients with angina and risk factors for microvascular disease (MVD), however fully quantitative CMR has not been studied. The purpose of this study is to evaluate whether fully quantitative CMR identifies reduced MPR in this population, and to investigate the relationship between epicardial atherosclerosis, left ventricular hypertrophy (LVH), extracellular volume (ECV), and perfusion.
   Methods: Forty-six patients with typical angina and risk factors for MVD (females, or males with diabetes or metabolic syndrome) who had no obstructive coronary artery disease by coronary angiography and 20 healthy control subjects underwent regadenoson stress CMR perfusion imaging using a dual-sequence quantitative spiral pulse sequence to quantify MPR. Subjects also underwent T1 mapping to quantify ECV, and computed tomographic (CT) coronary calcium scoring to assess atherosclerosis burden.
   Results: In patients with risk factors for MVD, both MPR (2.21 [1.95,2.69] vs. 2.93 [2.763.19], p < 0.001) and stress myocardial perfusion (2.65 +/- 0.62 ml/min/g, vs. 3.17 +/- 0.49 ml/min/g p < 0.002) were reduced as compared to controls. These differences remained after adjusting for age, left ventricular (LV) mass, body mass index (BMI), and gender. There were no differences in native T1 or ECV between subjects and controls.
   Conclusions: Stress myocardial perfusion and MPR as measured by fully quantitative CMR perfusion imaging are reduced in subjects with risk factors for MVD with no obstructive CAD as compared to healthy controls. Neither myocardial hypertrophy nor fibrosis accounts for these differences.
C1 [Zorach, Benjamin; Bourque, Jamieson; Balfour, Pelbreton C.; Yang, Yang; Mathew, Roshin; Pan, Jonathan; Taylor, Angela M.; Kramer, Christopher M.; Salerno, Michael] Univ Virginia Hlth Syst, Cardiol Div, Dept Med, Charlottesville, VA 22903 USA.
   [Shaw, Peter W.] Berkshire Med Ctr, Pittsfield, MA USA.
   [Bourque, Jamieson; Meyer, Craig H.; Epstein, Frederick H.; Kramer, Christopher M.; Salerno, Michael] Univ Virginia Hlth Syst, Cardiovasc Imaging Ctr, Dept Radiol, Charlottesville, VA 22903 USA.
   [Kuruvilla, Sujith] Univ Penn, Dept Med, Philadelphia VA Med Ctr, Perelman Sch Med, Philadelphia, PA 19104 USA.
   [Yang, Yang; Meyer, Craig H.; Epstein, Frederick H.; Salerno, Michael] Univ Virginia Hlth Syst, Dept Biomed Engn, Charlottesville, VA 22903 USA.
   [Gonzalez, Jorge A.] Scripps Clin, Div Cardiovasc Dis, Div Cardiol, Cardiovasc Imaging,Div Radiol, San Diego, CA USA.
C3 University of Virginia; University of Virginia (UVA) Health System;
   University of Virginia; University of Virginia (UVA) Health System;
   University of Pennsylvania; Pennsylvania Medicine; US Department of
   Veterans Affairs; Veterans Health Administration (VHA); Philadelphia
   Veterans Affairs Medical Center; University of Virginia; University of
   Virginia (UVA) Health System; Scripps Research Institute
RP Kramer, CM; Salerno, M (corresponding author), Univ Virginia Hlth Syst, Cardiol Div, Dept Med, Charlottesville, VA 22903 USA.; Kramer, CM; Salerno, M (corresponding author), Univ Virginia Hlth Syst, Cardiovasc Imaging Ctr, Dept Radiol, Charlottesville, VA 22903 USA.; Salerno, M (corresponding author), Univ Virginia Hlth Syst, Dept Biomed Engn, Charlottesville, VA 22903 USA.
EM ckramer@virginia.edu; ms5pc@virginia.edu
RI Carrizosa, Jorge/MVX-8993-2025; Yang, Yang/H-7280-2019
OI Taylor, Angela/0000-0003-4927-4320; Yang, Yang/0000-0002-2841-4243
FU UVA Health System Clinical Research Grant [NIH K23 HL112910, NIH K23
   HL119620, R01 HL131919, 5T32EB003841, R01 EB001763]; Siemens Medical
   Solutions
FX The work was funded by UVA Health System Clinical Research Grant, NIH
   K23 HL112910, NIH K23 HL119620, R01 HL131919, 5T32EB003841, R01
   EB001763, and Siemens Medical Solutions.
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NR 32
TC 79
Z9 81
U1 0
U2 4
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1097-6647
EI 1532-429X
J9 J CARDIOVASC MAGN R
JI J. Cardiov. Magn. Reson.
PD FEB 22
PY 2018
VL 20
AR 14
DI 10.1186/s12968-018-0435-1
PG 8
WC Cardiac & Cardiovascular Systems; Radiology, Nuclear Medicine & Medical
   Imaging
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Radiology, Nuclear Medicine &
   Medical Imaging
GA FX0WQ
UT WOS:000425768500001
PM 29471856
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Zhang, L
   Xu, D
   Zhang, BJ
   Liu, YS
   Chu, FL
   Guo, YM
   Gong, J
   Zheng, X
   Chen, LB
   Wang, H
AF Zhang, Li
   Xu, Dan
   Zhang, Benjian
   Liu, Yansong
   Chu, Fenglong
   Guo, Yuming
   Gong, Jun
   Zheng, Xun
   Chen, Liaobin
   Wang, Hui
TI Prenatal Food Restriction Induces a
   Hypothalamic-Pituitary-Adrenocortical Axis-associated Neuroendocrine
   Metabolic Programmed Alteration in Adult Offspring Rats
SO ARCHIVES OF MEDICAL RESEARCH
LA English
DT Article
DE Food restriction; Intrauterine growth restriction;
   Hypothalamic-pituitary-adrenal axis; Unpredictable chronic stress;
   High-fat diet; Metabolic syndrome
ID HIGH-FAT-DIET; CATCH-UP GROWTH; GREAT CHINESE FAMINE; ADRENAL AXIS;
   LATE-GESTATION; MATERNAL UNDERNUTRITION; NUTRIENT RESTRICTION;
   SEX-DIFFERENCES; FETAL ORIGINS; STRESS
AB Background and Aims. Intrauterine growth restriction produces susceptibility to adult metabolic syndrome, which may be caused by the permanent alteration of the hypothalamic-pituitary-adrenocortical (HPA) axis. We aimed to verify that HPA axis-associated neuroendocrine metabolic programming is altered in food-restricted (FR) offspring.
   Methods. Maternal rats were fed a restricted diet from gestational day 11 until full-term delivery, all pups were fed a high-fat diet after weaning and exposed to unpredictable chronic stress (UCS) during postnatal weeks 17-20.
   Results. Serum levels of adrenocorticotrophic hormone and corticosterone in adult offspring of the prenatal FR group were lower than the control (CN) rats before UCS but increased significantly after UCS. Serum glucose levels in the FR group were normal before UCS but increased after UCS. Serum insulin levels were significantly decreased in FR males but showed a slight increase in FR females before UCS; however, insulin levels decreased significantly in the FR male and female rats after UCS. Before UCS, serum lipid levels were higher in the FR males but were normal in the FR females; after UCS, FR males had a slight decrease and FR females had an increasing trend in serum lipids levels. Lipid droplets in the hypothalamus, pituitary gland, and livers of the FR group indicated steatosis.
   Conclusions. These results suggest that prenatal food restriction alters HPA axis-associated neuroendocrine metabolism in adult offspring fed a high-fat diet, which may originate from the intrauterine programming and increase the susceptibility to adult metabolic diseases. (C) 2013 IMSS. Published by Elsevier Inc.
C1 [Zhang, Li; Xu, Dan; Zhang, Benjian; Liu, Yansong; Guo, Yuming; Gong, Jun; Zheng, Xun; Wang, Hui] Wuhan Univ, Basic Med Sch, Dept Pharmacol, Wuhan 430071, Hubei Province, Peoples R China.
   [Xu, Dan; Wang, Hui] Wuhan Univ, Res Ctr Food & Drug Evaluat, Wuhan 430071, Hubei Province, Peoples R China.
   [Chu, Fenglong; Chen, Liaobin] Wuhan Univ, Dept Orthoped Surg, Zhongnan Hosp, Wuhan 430071, Hubei Province, Peoples R China.
C3 Wuhan University; Wuhan University; Wuhan University
RP Wang, H (corresponding author), Wuhan Univ, Basic Med Sch, Dept Pharmacol, Wuhan 430071, Hubei Province, Peoples R China.
EM wanghui19@whu.edu.cn
RI Guo, Yuming/AAH-1124-2021; Zhang, Benjian/ABC-1130-2020
OI Gong, Jun/0000-0001-9744-7201
FU National Natural Science Foundation of China [30830112, 81072709,
   81220108026, 81202240]; Chinese Ministry of Education [V200801]
FX This work was supported by grants from the National Natural Science
   Foundation of China (No. 30830112, 81072709, 81220108026 and 81202240),
   and the Key Grant Project of the Chinese Ministry of Education (No.
   V200801).
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NR 70
TC 35
Z9 40
U1 1
U2 17
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0188-4409
EI 1873-5487
J9 ARCH MED RES
JI Arch. Med. Res.
PD JUL
PY 2013
VL 44
IS 5
BP 335
EP 345
DI 10.1016/j.arcmed.2013.07.006
PG 11
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 223YH
UT WOS:000324847900002
PM 23911676
DA 2025-06-11
ER

PT J
AU Hattan, N
   Chilian, WM
   Park, F
   Rocic, P
AF Hattan, Naoichiro
   Chilian, William M.
   Park, Frank
   Rocic, Petra
TI Restoration of coronary collateral growth in the Zucker obese rat:
   Impact of VEGF and ecSOD
SO BASIC RESEARCH IN CARDIOLOGY
LA English
DT Article
DE collateral growth; gene therapy; coronary circulation; VEGF; obesity
ID ENDOTHELIAL DYSFUNCTION; NITRIC-OXIDE; GENE-THERAPY; ANGIOGENESIS;
   ISCHEMIA; REPERFUSION; LIVER
AB The metabolic syndrome (MS), a condition characterized by several risk factors for coronary artery disease, including obesity, is associated with endothelial dysfunction and oxidative stress. Because proper endothelial function is essential for signaling of certain growth factors (vascular endothelial growth factor, VEGF) we hypothesized that coronary collateral growth (CCG) is impaired in a model of the MS. To test this hypothesis, we stimulated coronary collateral growth in pre-diabetic Zucker obese fatty rats (OZR) and lean littermates (LZR) by using episodic, repetitive ischemia (RI: 40 s left anterior descending arterial occlusion, 24/d for 14 d). Myocardial blood flow (MBF, radioactive microspheres) was measured in the normal (NZ) and collateral-dependent (ischemic) zones (CZ); CCG was assessed as a ratio of CZ/NZ flow (unity represents complete restoration of CZ flow). In LZR, CZ/NZ ratio increased from 0.18 +/- 0.03 to 0.81 +/- 0.07 after RI (P < 0.05). In contrast, in OZR rats CZ/NZ did not increase after RI (0.15 +/- 0.04 vs 0.18 +/- 0.04). To rectify abrogated collateral growth in OZR, we employed VEGF gene therapy (VEGF-transduced, strained-matched, cultured vascular smooth muscle cells [cVSMCs], delivered intracoronary). VEGF therapy modestly but not significantly increased the CZ/NZ ratio after RI (0.16 +/- 0.05 vs 0.33 +/- 0.06). To facilitate VEGF signaling,we reduced oxidative stress by transducing cVSMCs with both ecSOD and VEGF. This increased the CZ/NZ flow ratio after RI to 0.52 +/- 0.04 (p < 0.05 vs. OZR [(0.19 +/- 0.04]) indicating partial restoration of collateral growth. Our results demonstrate that coronary collateral growth is impaired in a model of the metabolic syndrome and that growth factor gene therapy with VEGF is made far more effective when it is coupled to an intervention that reduces oxidative stress.
C1 Louisiana State Univ, Hlth Sci Ctr, Dept Physiol, New Orleans, LA 70112 USA.
   Louisiana State Univ, Hlth Sci Ctr, Dept Pharmacol, Cardiovasc Ctr Excellence,Program Gene Therapy, New Orleans, LA 70112 USA.
C3 Louisiana State University System; Louisiana State University Health
   Sciences Center New Orleans; Louisiana State University System;
   Louisiana State University Health Sciences Center New Orleans
RP Rocic, P (corresponding author), Louisiana State Univ, Hlth Sci Ctr, Dept Physiol, 1901 Perdido St,Med Educ Bldg, New Orleans, LA 70112 USA.
EM procic@gmail.com
RI Park, Frank/I-4590-2019
OI Park, Frank/0000-0003-2324-2937; Rocic, Petra/0000-0002-5781-3075
FU NCRR NIH HHS [RR 018766] Funding Source: Medline; NHLBI NIH HHS [HL
   65203, HL 73755, HL 32788] Funding Source: Medline
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NR 23
TC 40
Z9 45
U1 0
U2 2
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0300-8428
EI 1435-1803
J9 BASIC RES CARDIOL
JI Basic Res. Cardiol.
PD MAY
PY 2007
VL 102
IS 3
BP 217
EP 223
DI 10.1007/s00395-007-0646-3
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 154PK
UT WOS:000245519500004
PM 17323199
DA 2025-06-11
ER

PT J
AU Kupczyk, D
   Bilski, R
   Sokolowski, K
   Pawlowska, M
   Wozniak, A
   Szewczyk-Golec, K
AF Kupczyk, D.
   Bilski, R.
   Sokolowski, K.
   Pawlowska, M.
   Wozniak, A.
   Szewczyk-Golec, K.
TI Paraoxonase 1: The Lectin-Like Oxidized LDL Receptor Type I and
   Oxidative Stress in the Blood of Men with Type II Obesity
SO DISEASE MARKERS
LA English
DT Article
ID METABOLIC SYNDROME; INSULIN-RESISTANCE; LOX-1; INFLAMMATION; TISSUE
AB Objectives. Obesity has serious consequences such as the onset of metabolic syndrome, type 2 diabetes, atherosclerosis, or cardiovascular complications. The aim of this study was to evaluate the levels of paraoxonase 1 (PON1), lectin-like oxidized LDL receptor-1 (LOX-1), antioxidant enzymes (superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx)), and lipid peroxidation processes in the course of obesity. Methods. 28 men took part in the experiment. Fourteen of them were obese; the control group consisted of 14 physically active men without obesity features. The concentrations of malondialdehyde (MDA), PON1, LOX-1, and tumor necrosis factor alpha (TNF alpha) as well as the activities of erythrocytic SOD, CAT, and GPx were determined in the study. Results. Statistically significant higher MDA, LOX-1, and TNF alpha levels were observed in obese subjects. Conversely, lower concentrations of PON1 in obese men were found. Conclusions. An imbalance in oxidation-reduction processes accompanies obesity. Moreover, inflammatory cytokines and atherosclerotic complications are involved in the obesity process. The obtained results suggest that the studied parameters may be independent prognostic markers preceding the development of cardiovascular and metabolic complications in people afflicted with type II obesity.
C1 [Kupczyk, D.; Bilski, R.; Pawlowska, M.; Wozniak, A.; Szewczyk-Golec, K.] Nicolaus Copernicus Univ Torun, Ludwik Rydygier Coll Med Bydgoszcz, Dept Med Biol & Biochem, Karlowicza 24, PL-85092 Bydgoszcz, Poland.
   [Sokolowski, K.] Family Med Clin Dr Dariusz Gorecki & Partners, Przesmyk 2-4, PL-87100 Torun, Poland.
C3 Nicolaus Copernicus University
RP Bilski, R (corresponding author), Nicolaus Copernicus Univ Torun, Ludwik Rydygier Coll Med Bydgoszcz, Dept Med Biol & Biochem, Karlowicza 24, PL-85092 Bydgoszcz, Poland.
EM rafal.bilski@cm.umk.pl
RI Kupczyk, Daria/P-6159-2015; Pawłowska, Marta/Q-8361-2019; Wozniak,
   Alina/H-4699-2014; Szewczyk-Golec, Karolina/E-9110-2014; Bilski,
   Rafal/P-6170-2015
OI Pawlowska, Marta/0000-0003-1640-9196; Wozniak,
   Alina/0000-0002-4492-4796; Szewczyk-Golec, Karolina/0000-0001-8123-3882;
   Bilski, Rafal/0000-0002-5197-4281; Kupczyk, Daria/0000-0003-1542-0879
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NR 45
TC 9
Z9 9
U1 0
U2 4
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 0278-0240
EI 1875-8630
J9 DIS MARKERS
JI Dis. Markers
PD OCT 15
PY 2019
VL 2019
AR 6178017
DI 10.1155/2019/6178017
PG 7
WC Biotechnology & Applied Microbiology; Genetics & Heredity; Medicine,
   Research & Experimental; Pathology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Genetics & Heredity; Research &
   Experimental Medicine; Pathology
GA JH9RR
UT WOS:000493106100001
PM 31737129
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Cho, S
   Namkoong, K
   Shin, M
   Park, J
   Yang, E
   Ihm, J
   Thu, VT
   Kim, HK
   Han, J
AF Cho, Sanghyun
   Namkoong, Kyung
   Shin, Minji
   Park, Jueun
   Yang, Eunyeong
   Ihm, Jinsoo
   Vu Thi Thu
   Kim, Hyoung Kyu
   Han, Jin
TI Cardiovascular Protective Effects and Clinical Applications of
   Resveratrol
SO JOURNAL OF MEDICINAL FOOD
LA English
DT Review
DE cardiovascular disease; clinical application; resveratrol
ID IMPROVES ENDOTHELIAL FUNCTION; ACTIVATED PROTEIN-KINASE; OXIDATIVE
   STRESS; METABOLIC SYNDROME; PRIMARY PREVENTION; GENE-EXPRESSION;
   CARDIAC-HYPERTROPHY; FRENCH PARADOX; NITRIC-OXIDE; MITOCHONDRIAL
   BIOGENESIS
AB Resveratrol is a naturally occurring phenol that is generated by plant species following injury or attack by bacterial and fungal pathogens. This compound was first described as the French Paradox in 1992. Later in 2003, resveratrol was reported to activate sirtuins in yeast cells. Recent experimental studies have found that resveratrol offers a variety of benefits that include both anticarcinogenic and anti-inflammatory effects in addition to the ability to reverse obesity, attenuate hyperglycemia and hyperinsulinemia, protect heart and endothelial function, and increase the life span. Multiple molecular targets are associated with the cardioprotective capabilities of resveratrol, and therefore, resveratrol has potential for a wide range of new therapeutic strategies for atherosclerosis, ischemia/ reperfusion, metabolic syndrome, cardiac failure, and inflammatory alterations during aging. Expectations for application in human patients, however, suffer from a lack of sufficient clinical evidence in support of these beneficial effects. This article reviews recently reported basic research results that describe the beneficial effects of resveratrol in an attempt to condense the evidence observed in clinical trials and provide support for the future development of novel clinical therapeutics in patients with cardiovascular diseases.
C1 [Cho, Sanghyun; Namkoong, Kyung; Shin, Minji; Park, Jueun; Yang, Eunyeong; Ihm, Jinsoo; Vu Thi Thu; Kim, Hyoung Kyu; Han, Jin] Inje Univ, Natl Res Lab Mitochondrial Signaling, Cardiovasc & Metab Dis Ctr,Project Team BK21, Dept Hlth Sci & Technol,Dept Physiol,Coll Med, Busan, South Korea.
   [Vu Thi Thu] VNU Univ Sci, Fac Biol, Key Lab Enzyme & Prot Technol, Hanoi, Vietnam.
   [Kim, Hyoung Kyu] Inje Univ, Coll Med, Dept Integrated Biomed Sci, Busan, South Korea.
C3 Inje University; Vietnam National University Hanoi (VNU Hanoi) System;
   VNU University of Science (VNU-HUS); Inje University
RP Kim, HK; Han, J (corresponding author), Inje Univ, Natl Res Lab Mitochondrial Signaling, Cardiovasc & Metab Dis Ctr, Plus Project Team BK21,Dept Physiol,Coll Med, Bokji Ro 75, Busan 47392, South Korea.
EM estrus74@gmail.com; phyhanj@inje.ac.kr
RI Kim, Hyung/J-5451-2012
OI Kim, Hyoung Kyu/0000-0002-1791-7865; Cho, Sanghyun/0009-0006-8591-4654
FU Priority Research Centers Program of the National Research Foundation of
   Korea (NRF) - Ministry of Education, Science and Technology of the
   Republic of Korea [2010-0020224, 2015R1A2A1A13001900, 2015R1D1A1A
   01057937]
FX These investigators were supported by grants (2010-0020224,
   2015R1A2A1A13001900, and 2015R1D1A1A 01057937) from the Priority
   Research Centers Program of the National Research Foundation of Korea
   (NRF), which is funded by the Ministry of Education, Science and
   Technology of the Republic of Korea.
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NR 130
TC 70
Z9 76
U1 2
U2 40
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1096-620X
EI 1557-7600
J9 J MED FOOD
JI J. Med. Food
PD APR
PY 2017
VL 20
IS 4
BP 323
EP 334
DI 10.1089/jmf.2016.3856
PG 12
WC Chemistry, Medicinal; Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Food Science & Technology; Nutrition &
   Dietetics
GA ES4HU
UT WOS:000399494700001
PM 28346848
DA 2025-06-11
ER

PT J
AU Laight, DW
AF Laight, DW
TI Therapeutic approaches to the management of dysmetabolic cardiovascular
   disease
SO EXPERT OPINION ON THERAPEUTIC PATENTS
LA English
DT Review
DE antioxidants; atherosclerosis; dysglycaemia; dyslipidaemia; endothelium;
   insulin resistance; nitric oxide; obesity; oxidant stress; syndrome X;
   Type 2 diabetes
ID ACTIVATED RECEPTOR-GAMMA; INSULIN-RESISTANCE; DIABETES-MELLITUS;
   DOUBLE-BLIND; WEIGHT-LOSS; RISK-FACTORS; PREVENTION; ORLISTAT; ACARBOSE;
   ABNORMALITIES
AB Metabolic abnormalities, such as impaired insulin sensitivity, hyperinsulinaemia, dysglycaemia and dyslipidaemia, often encountered ensemble in syndrome X, are acknowledged risk factors for cardiovascular disease that may play significant roles in the accelerated development of macrovascular disease associated with insulin resistance and Type 2 diabetes. Indeed, just as tight glycaemic control has alleviated diabetic microangiopathy, there is now a possibility that targeting the proposed fundamental feature of syndromeX, insulin resistance, will play a leading part, in not only preventing Type 2 diabetes, but also in reducing the burden of both prediabetic and diabetic macrovascular disease. This may be optimally achieved with multiple risk factor interventions that improve insulin sensitivity and modify traditional and newly described dysmetabolic and pro-atherogenic factors.
C1 Univ Portsmouth, Sch Pharm & Biomed Sci, Portsmouth PO1 2DT, Hants, England.
C3 University of Portsmouth
RP Univ Portsmouth, Sch Pharm & Biomed Sci, White Swan Rd, Portsmouth PO1 2DT, Hants, England.
EM David.Laight@port.ac.uk
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TC 2
Z9 2
U1 0
U2 0
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1354-3776
EI 1744-7674
J9 EXPERT OPIN THER PAT
JI Expert Opin. Ther. Patents
PD MAY
PY 2002
VL 12
IS 5
BP 615
EP 620
DI 10.1517/13543776.12.5.615
PG 6
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 553BT
UT WOS:000175656200001
DA 2025-06-11
ER

PT J
AU Kanda, T
   Goto, T
   Hirotsu, Y
   Masuzaki, R
   Moriyama, M
   Omata, M
AF Kanda, Tatsuo
   Goto, Taichiro
   Hirotsu, Yosuke
   Masuzaki, Ryota
   Moriyama, Mitsuhiko
   Omata, Masao
TI Molecular Mechanisms: Connections between Nonalcoholic Fatty Liver
   Disease, Steatohepatitis and Hepatocellular Carcinoma
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE dysbiosis; HCC; HSD17B13; NAFLD; NASH; metabolic syndrome; microbiota;
   obesity; PNPLA3
ID INTESTINAL BACTERIAL OVERGROWTH; FIBROSIS PROGRESSION; AMERICAN
   ASSOCIATION; INSULIN-RESISTANCE; OXIDATIVE STRESS; UNITED-STATES;
   PLASMA-LEVELS; BILE-ACIDS; OBESITY; PROTEIN
AB Nonalcoholic fatty liver disease (NAFLD), including nonalcoholic steatohepatitis (NASH), causes hepatic fibrosis, cirrhosis and hepatocellular carcinoma (HCC). The patatin-like phospholipase-3 (PNPLA3) I148M sequence variant is one of the strongest genetic determinants of NAFLD/NASH. PNPLA3 is an independent risk factor for HCC among patients with NASH. The obesity epidemic is closely associated with the rising prevalence and severity of NAFLD/NASH. Furthermore, metabolic syndrome exacerbates the course of NAFLD/NASH. These factors are able to induce apoptosis and activate immune and inflammatory pathways, resulting in the development of hepatic fibrosis and NASH, leading to progression toward HCC. Small intestinal bacterial overgrowth (SIBO), destruction of the intestinal mucosa barrier function and a high-fat diet all seem to exacerbate the development of hepatic fibrosis and NASH, leading to HCC in patients with NAFLD/NASH. Thus, the intestinal microbiota may play a role in the development of NAFLD/NASH. In this review, we describe recent advances in our knowledge of the molecular mechanisms contributing to the development of hepatic fibrosis and HCC in patients with NAFLD/NASH.
C1 [Kanda, Tatsuo; Masuzaki, Ryota; Moriyama, Mitsuhiko] Nihon Univ, Div Gastroenterol & Hepatol, Dept Med, Sch Med,Itabashi Ku, 30-1 Oyaguchi Kamicho, Tokyo 1738610, Japan.
   [Goto, Taichiro] Yamanashi Cent Hosp, Lung Canc & Resp Dis Ctr, 1-1-1 Fujimi, Kofu, Yamanashi 4008506, Japan.
   [Hirotsu, Yosuke; Omata, Masao] Yamanashi Cent Hosp, Genome Anal Ctr, Yamanashi 4008506, Japan.
   [Omata, Masao] Univ Tokyo, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1138655, Japan.
C3 Nihon University; University of Tokyo
RP Goto, T (corresponding author), Yamanashi Cent Hosp, Lung Canc & Resp Dis Ctr, 1-1-1 Fujimi, Kofu, Yamanashi 4008506, Japan.
EM kanda2t@yahoo.co.jp; taichiro@1997.jukuin.keio.ac.jp;
   hirotsu-bdyu@ych.pref.yamanashi.jp; masuzaki.ryota@nihon-u.ac.jp;
   moriyama.mitsuhiko@nihon-u.ac.jp; m-omata0901@ych.pref.yamanashi.jp
RI Yosuke, Hirotsu/IQR-4402-2023; Goto, Taichiro/AAM-5276-2020; Kanda,
   Tatsuo/AFA-8767-2022
OI Kanda, Tatsuo/0000-0002-1654-5385; Hirotsu, Yosuke/0000-0002-8002-834X;
   Kanda, Tatsuo/0009-0000-8135-342X; Goto, Taichiro/0000-0002-2560-3639
FU JSPS KAKENHI [17K09404]; Grants-in-Aid for Scientific Research
   [17K09404] Funding Source: KAKEN
FX This work was partly supported by JSPS KAKENHI grant number 17K09404 (to
   T.K.).
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NR 115
TC 72
Z9 73
U1 3
U2 59
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD FEB
PY 2020
VL 21
IS 4
AR 1525
DI 10.3390/ijms21041525
PG 17
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA KY4FE
UT WOS:000522524400352
PM 32102237
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Carnagarin, R
   Carlessi, R
   Newsholme, P
   Dharmarajan, AM
   Dass, CR
AF Carnagarin, Revathy
   Carlessi, Rodrigo
   Newsholme, Philip
   Dharmarajan, Arun M.
   Dass, Crispin R.
TI Pigment epithelium-derived factor stimulates skeletal muscle glycolytic
   activity through NADPH oxidase-dependent reactive oxygen species
   production
SO INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
LA English
DT Article
DE PEDF; Skeletal muscle; Reactive oxygen species; Glycolysis;
   Antioxidants; NADPH oxidase
ID ADIPOSE TRIGLYCERIDE LIPASE; INDUCED OXIDATIVE STRESS; FACTOR PEDF;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; SERUM-LEVELS; CELLS; CANCER;
   DIFFERENTIATION; IDENTIFICATION
AB Pigment epithelium-derived factor is a multifunctional serpin implicated in insulin resistance in metabolic disorders. Recent evidence suggests that exposure of peripheral tissues such as skeletal muscle to PEDF has profound metabolic consequences with predisposition towards chronic conditions such as obesity, type 2 diabetes, metabolic syndrome and polycystic ovarian syndrome. Chronic inflammation shifts muscle metabolism towards increased glycolysis and decreased oxidative metabolism. In the present study, we demonstrate a novel effect of PEDF on cellular metabolism in mouse cell line (C2C12) and human primary skeletal muscle cells. PEDF addition to skeletal muscle cells induced enhanced phospholipase A2 activity. This was accompanied with increased production of reactive oxygen species in a nicotinamide adenine dinucleotide phosphate (NADPH) oxidase-dependent manner that triggered a shift towards a more glycolytic phenotype. Extracellular flux analysis and glucose consumption assays demonstrated that PEDF treatment resulted in enhanced glycolysis but did not change mitochondrial respiration. Our results demonstrate that skeletal muscle cells express a PEDF-inducible oxidant generating system that enhances glycolysis but is sensitive to antioxidants and NADPH oxidase inhibition. (C) 2016 Elsevier Ltd. All rights reserved.
C1 [Carnagarin, Revathy; Carlessi, Rodrigo; Newsholme, Philip; Dharmarajan, Arun M.; Dass, Crispin R.] Curtin Hlth Innovat Res Inst, Bentley, WA 6102, Australia.
   [Carnagarin, Revathy; Dass, Crispin R.] Curtin Univ, Sch Pharm, Bentley, WA 6102, Australia.
   [Carnagarin, Revathy; Dharmarajan, Arun M.] Curtin Univ, Sch Biomed Sci, Stem Cell & Canc Biol Lab, Bentley, WA 6102, Australia.
   [Carnagarin, Revathy; Carlessi, Rodrigo; Newsholme, Philip] Curtin Univ, Sch Biomed Sci, Bentley, WA 6102, Australia.
C3 Curtin University; Curtin University; Curtin University
RP Dass, CR (corresponding author), Curtin Univ, Sch Pharm, GPO Box U1987, Perth, WA 6845, Australia.
EM Crispin.Dass@curtin.edu.au
RI Newsholme, Philip/D-4939-2016; Carlessi, Rodrigo/JCE-0678-2023
OI Carlessi, Rodrigo/0000-0003-0038-7391; Dharmarajan,
   Arun/0000-0002-6715-6005; Carnagarin, Revathy/0000-0003-4714-0206; Dass,
   Crispin/0000-0001-7087-7957
FU International Postgraduate Research Scholarship (IPRS) at Curtin
   University; Curtin Academic50
FX The authors acknowledge support provided by the International
   Postgraduate Research Scholarship (IPRS) at Curtin University to RC, and
   Curtin Academic50 support to CRD, and Dr Pat Methoram and Dr Younan Chen
   for various reagents and experimental advice.
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Z9 13
U1 1
U2 5
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 1357-2725
EI 1878-5875
J9 INT J BIOCHEM CELL B
JI Int. J. Biochem. Cell Biol.
PD SEP
PY 2016
VL 78
BP 229
EP 236
DI 10.1016/j.biocel.2016.06.013
PG 8
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA DV9YE
UT WOS:000383297300024
PM 27343430
DA 2025-06-11
ER

PT J
AU Esmaealzadeh, D
   Ghalibaf, AM
   Rad, MS
   Rezaee, R
   Razavi, BM
   Hosseinzadeh, H
AF Esmaealzadeh, Danial
   Ghalibaf, AmirAli Moodi
   Rad, Mohammad Shariati
   Rezaee, Ramin
   Razavi, Bibi Marjan
   Hosseinzadeh, Hossein
TI Pharmacological effects of Safranal: An updated review
SO IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
LA English
DT Review
DE Crocus sativus Patent Review Saffron Safranal
ID SAFFRON CROCUS-SATIVUS; IN-VITRO ASSAYS; OXIDATIVE STRESS; AERIAL PARTS;
   VOLATILE CONSTITUENTS; ACTIVE CONSTITUENT; CANCER-THERAPY;
   BLOOD-PRESSURE; POTENTIAL USE; SERUM-LEVELS
AB Safranal (a monoterpene aldehyde) is the major volatile component of saffron which is responsible for the saffron unique odor. Several studies have shown the pharmacological activities of safranal including anti-oxidant, anti-inflammatory, cardioprotective, neuroprotective, nephroprotective, gastrointestinal protective, etc. This study was designed to review the pharmacological and medical effects of safranal and up-to-date previous knowledge. Moreover, some patents related to the pharmacological effects of safranal were gathered. Therefore, electronic databases including Web of Sciences, Scopus, and Pubmed for pharmacological effects and US patent, Patentscope, and Google Patent for patents were comprehensively searched by related English keywords from 2010 to June 2022. According to our review, most of the studies are related to the safranal effects on CNS such as antianxiety, analgesic, anticonvulsant, antiischemic, anti-tremor, memory enhancement and its protective effects on neurodegenerative disorders such as Alzheimer's, Parkinson and Huntington diseases. Other effects of safranal are antiasthmatic, antihypertensive, antiaging, anticataract, etc. Moreover, the protective effects of this agent on metabolic syndrome and diabetic nephropathy have been shown. Different mechanisms including anti-oxidant, anti-inflammatory, muscle relaxation, antiapoptotic, and regulatory effects on the genes and proteins expression related to signaling pathways of oxidative stress, inflammation, apoptosis, proliferation, etc. are involved in safranal pharmacological effects. Some patents for the prevention and/or treatment of different diseases such as liver cancer, sleep disorder, depression, cognitive disorder, obesity and PMS were also included. Based on the documents, safranal is considered a promising therapeutic agent although more clinical studies are needed to verify the beneficial effects of safranal in humans.
C1 [Esmaealzadeh, Danial; Rad, Mohammad Shariati] Mashhad Univ Med Sci, Sch Med, Mashhad, Iran.
   [Ghalibaf, AmirAli Moodi] Birjand Univ Med Sci, Student Res Comm, Fac Med, Birjand, Iran.
   [Rezaee, Ramin] Mashhad Univ Med Sci, Fac Med, Int UNESCO Ctr Hlth Related Basic Sci & Human Nutr, Mashhad, Iran.
   [Rezaee, Ramin] Mashhad Univ Med Sci, Appl Biomed Res Ctr, Mashhad, Iran.
   [Razavi, Bibi Marjan] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Targeted Drug Delivery Res Ctr, Mashhad, Iran.
   [Razavi, Bibi Marjan; Hosseinzadeh, Hossein] Mashhad Univ Med Sci, Sch Pharm, Dept Pharmacodynam & Toxicol, Mashhad, Iran.
   [Hosseinzadeh, Hossein] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Pharmaceut Res Ctr, Mashhad, Iran.
C3 Mashhad University of Medical Sciences; Birjand University of Medical
   Sciences; Mashhad University of Medical Sciences; Mashhad University of
   Medical Sciences; Mashhad University of Medical Sciences; Mashhad
   University of Medical Sciences; Mashhad University of Medical Sciences
RP Razavi, BM (corresponding author), Mashhad Univ Med Sci, Pharmaceut Technol Inst, Targeted Drug Delivery Res Ctr, Mashhad, Iran.; Hosseinzadeh, H (corresponding author), Mashhad Univ Med Sci, Pharmaceut Technol Inst, Pharmaceut Res Ctr, Mashhad, Iran.
EM razavimr@mums.ac.ir; hosseinzadehh@mums.ac.ir
RI Razavi, Bibi/AAY-5636-2020; Rezaee, Ramin/T-7810-2017; Hosseinzadeh,
   Hossein/F-3013-2010; Moodi Ghalibaf, AmirAli/AAX-1722-2021
FU Pharmaceutical Research Center at Mashhad University of Medical
   Sciences, Iran
FX This work was supported by the Pharmaceutical Research Center and the
   Vice Chancellor of Research, at Mashhad University of Medical Sciences,
   Iran.
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NR 124
TC 18
Z9 18
U1 7
U2 14
PU MASHHAD UNIV MED SCIENCES
PI MASHHAD
PA VICE-CHANCELLOR FOR RES CTR OFF IJBMS, DANESHGAH ST, PO BOX 9138813944 -
   445, MASHHAD, 00000, IRAN
SN 2008-3866
EI 2008-3874
J9 IRAN J BASIC MED SCI
JI Iran. J. Basic Med. Sci.
PD OCT
PY 2023
VL 26
IS 10
BP 1131
EP 1143
DI 10.22038/IJBMS.2023.69824.15197
PG 13
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA CH0I5
UT WOS:001124240800010
PM 37736506
DA 2025-06-11
ER

PT J
AU Fang, CL
   Liu, B
   Wan, M
AF Fang, Ching-Lien
   Liu, Bin
   Wan, Mei
TI "Bone-SASP" in Skeletal Aging
SO CALCIFIED TISSUE INTERNATIONAL
LA English
DT Review
DE Bone-SASP; Cellular senescence; Osteoarthritis; Osteoporosis; Premature
   aging syndromes; Progeria syndrome; Senescence-associated secretory
   phenotype (SASP); Skeletal aging
ID MESENCHYMAL STEM-CELLS; TELOMERIC DNA-DAMAGE; NF-KAPPA-B; CELLULAR
   SENESCENCE; SECRETORY PHENOTYPE; POSTTRAUMATIC OSTEOARTHRITIS;
   OSTEOGENIC DIFFERENTIATION; METABOLIC SYNDROME; INDUCED EXPRESSION;
   OXIDATIVE STRESS
AB Senescence is a complex cell state characterized by stable cell cycle arrest and a unique secretory pattern known as the senescence-associated secretory phenotype (SASP). The SASP factors, which are heterogeneous and tissue specific, normally include chemokines, cytokines, growth factors, adhesion molecules, and lipid components that can lead to multiple age-associated disorders by eliciting local and systemic consequences. The skeleton is a highly dynamic organ that changes constantly in shape and composition. Senescent cells in bone and bone marrow produce diverse SASP factors that induce alterations of the skeleton through paracrine effects. Herein, we refer to bone cell-associated SASP as "bone-SASP." In this review, we describe current knowledge of cellular senescence and SASP, focusing on the role of senescent cells in mediating bone pathologies during natural aging and premature aging syndromes. We also summarize the role of cellular senescence and the bone-SASP in glucocorticoids-induced bone damage. In addition, we discuss the role of bone-SASP in the development of osteoarthritis, highlighting the mechanisms by which bone-SASP drives subchondral bone changes in metabolic syndrome-associated osteoarthritis.
C1 [Fang, Ching-Lien; Liu, Bin; Wan, Mei] Johns Hopkins Univ, Sch Med, Dept Orthopaed Surg, Baltimore, MD 21205 USA.
   [Wan, Mei] Johns Hopkins Univ, Sch Med, Dept Orthopaed Surg, Ross Bldg,Room 209,720 Rutland Ave, Baltimore, MD 21205 USA.
C3 Johns Hopkins University; Johns Hopkins University
RP Wan, M (corresponding author), Johns Hopkins Univ, Sch Med, Dept Orthopaed Surg, Baltimore, MD 21205 USA.; Wan, M (corresponding author), Johns Hopkins Univ, Sch Med, Dept Orthopaed Surg, Ross Bldg,Room 209,720 Rutland Ave, Baltimore, MD 21205 USA.
EM mwan4@jhmi.edu
FU National Institutes of Health [R01AG068226, R01AG072090, P01AG066603]
FX AcknowledgementsThe authors acknowledge the assistance of Rachel Box,
   MS, at The Johns Hopkins Department of Orthopedic Surgery Editorial
   Services for editing the manuscript. This work was supported by the
   National Institutes of Health grant R01AG068226 and R01AG072090 to M.W.
   and P01AG066603 to X.C.
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NR 220
TC 19
Z9 21
U1 9
U2 37
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0171-967X
EI 1432-0827
J9 CALCIFIED TISSUE INT
JI Calcif. Tissue Int.
PD JUL
PY 2023
VL 113
IS 1
SI SI
BP 68
EP 82
DI 10.1007/s00223-023-01100-4
EA MAY 2023
PG 15
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA L1GX3
UT WOS:000998319700001
PM 37256358
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Bergmann, K
   Sypniewska, G
AF Bergmann, Katarzyna
   Sypniewska, Grazyna
TI Diabetes as a complication of adipose tissue dysfunction. Is there a
   role for potential new biomarkers?
SO CLINICAL CHEMISTRY AND LABORATORY MEDICINE
LA English
DT Review
DE adipokines; adipose tissue; diabetes type 2; inflammation; insulin
   resistance; obesity
ID ACID-BINDING PROTEIN; DIPEPTIDYL-PEPTIDASE 4; METABOLIC SYNDROME;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; GENE-EXPRESSION; OBESITY;
   INFLAMMATION; ADIPOKINES; CHEMERIN
AB Increasing incidence of type 2 diabetes is a major health problem of the modern world and requires new diagnostic tools to assess early metabolic disorders, particularly insulin resistance. The link between obesity, inflammation and insulin resistance indicates the important secretory role of adipose tissue. Proinflammatory factors (cytokines, adipokines) produced by enlarged adipose tissue are related to impaired glucose metabolism. Adipokines act as paracrine factors in adipose tissue and as endocrine hormones in the liver, muscles and central nervous system. Novel adipokines secreted from adipocytes such as retinol binding protein-4 (RBP-4), vaspin, omentin, chemerin, fibroblast growth factor 21 (FGF21), adipocyte fatty acid-binding protein (A-FABP) and dipeptidyl peptidase 4 (DPP4) demonstrate pleiotropic activity and their insulin-sensitizing or enhancing insulin resistance properties have not been clearly confirmed yet. In spite of the lack of standardized automated assay methods currently available for these novel biomarkers, promising results from several studies emphasize that they might potentially be useful prognostic factors for diabetes and its complications, especially in individuals without the typical symptoms of metabolic syndrome.
C1 [Bergmann, Katarzyna; Sypniewska, Grazyna] Nicholas Copernicus Univ, Coll Med Bydgoszcz, Dept Lab Med, Bydgoszcz, Poland.
C3 Nicolaus Copernicus University
RP Bergmann, K (corresponding author), Nicholas Copernicus Univ, Coll Med Bydgoszcz, Dept Lab Med, Bydgoszcz, Poland.
EM bergmann@vp.pl
RI ODROWAZ-SYPNIEWSKA, GRAZYN/H-1088-2014; Bergmann, Katarzyna/D-4228-2014
OI Bergmann, Katarzyna/0000-0001-9912-0325
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NR 66
TC 66
Z9 75
U1 0
U2 36
PU WALTER DE GRUYTER GMBH
PI BERLIN
PA GENTHINER STRASSE 13, D-10785 BERLIN, GERMANY
SN 1434-6621
EI 1437-4331
J9 CLIN CHEM LAB MED
JI Clin. Chem. Lab. Med.
PD JAN
PY 2013
VL 51
IS 1
BP 177
EP 185
DI 10.1515/cclm-2012-0490
PG 9
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA 056NP
UT WOS:000312497600017
PM 23241684
OA Bronze
DA 2025-06-11
ER

PT J
AU Cho, HS
   Lee, SW
   Kim, ES
   Shin, J
   Moon, SD
   Han, JH
   Cha, BY
AF Cho, Hyun Sun
   Lee, Sung Won
   Kim, Eun Sook
   Shin, Juyoung
   Moon, Sung Dae
   Han, Je Ho
   Cha, Bong Yun
TI Serum bilirubin levels are inversely associated with PAI-1 and
   fibrinogen in Korean subjects
SO ATHEROSCLEROSIS
LA English
DT Article
DE Bilirubin; Plasminogen activator inhibitor-1; Fibrinogen;
   Atherosclerosis
ID GILBERTS-SYNDROME; CARDIOVASCULAR PROTECTION; PLATELET ACTIVATION;
   METABOLIC SYNDROME; OXIDATIVE STRESS; UNCONJUGATED BILIRUBIN;
   MYOCARDIAL-INFARCTION; INSULIN-RESISTANCE; HEART-DISEASE; RISK
AB Objectives: Oxidative stress may contribute to atherosclerosis and increased activation of the coagulation pathway. Bilirubin may reduce activation of the hemostatic system to inhibit oxidative stress, which would explain its cardioprotective properties shown in many epidemiological studies. This study investigated the association of serum bilirubin with fibrinogen and plasminogen activator inhibitor-1 (PAI-1), respectively.
   Methods: A cross-sectional analysis was performed on 968 subjects (mean age, 56.0 +/- 11.2 years; 61.1% men) undergoing a general health checkup. Serum biochemistry was analyzed including bilirubin sub-types, insulin resistance (using homeostasis model of assessment [HOMA]), C-reactive protein (CRP), fibrinogen, and PAI-1.
   Results: Compared with subjects with a total bilirubin (TB) concentration of <10.0 mu mol/L, those with a TB concentration of >17.1 mu mol/L had a smaller waist circumference, a lower triglyceride level, a lower prevalence of metabolic syndrome, and decreased HOMA-IR and CRP levels. Correlation analysis revealed linear relationships of fibrinogen with TB and direct bilirubin (DB), whereas PAI-1 was correlated with DB. After adjustment for confounding factors, bilirubin levels were inversely associated with fibrinogen and PAI-1 levels, respectively. Multivariate regression models showed a negative linear relationship between all types of bilirubin and fibrinogen, whereas there was a significant linear relationship between PAI-1 and DB.
   Conclusions: High bilirubin concentrations were independently associated with low levels of fibrinogen and PAI-1, respectively. The association between TB and PAI-1 was confined to the highest TB concentration category whereas DB showed a linear association with PAI-1. Bilirubin may protect against the development of atherothrombosis by reducing the hemostatic response. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
C1 [Cho, Hyun Sun; Lee, Sung Won; Kim, Eun Sook; Shin, Juyoung; Moon, Sung Dae; Han, Je Ho; Cha, Bong Yun] Catholic Univ Korea, Dept Internal Med, Coll Med, Seoul 137701, South Korea.
   [Kim, Eun Sook; Moon, Sung Dae; Han, Je Ho] Catholic Univ Korea, Dept Internal Med, Coll Med, Div Endocrinol & Metab, Seoul 137701, South Korea.
   [Lee, Sung Won] Catholic Univ Korea, Dept Internal Med, Coll Med, Div Hepatol, Seoul 137701, South Korea.
   [Cho, Hyun Sun; Shin, Juyoung] Catholic Univ Korea, Seoul St Marys Hosp, Coll Med, Hlth Promot Ctr, Seoul 137701, South Korea.
C3 Catholic University of Korea; Catholic University of Korea; Catholic
   University of Korea; Seoul St. Mary's Hospital; Catholic University of
   Korea
RP Kim, ES (corresponding author), Catholic Univ Korea, Dept Internal Med, Incheon St Marys Hosp, Div Endocrinol & Metab,Coll Med, 222 Banpo Daero, Seoul 137701, South Korea.
EM 13900@catholic.ac.kr
RI Kim, Jang-Hee/AAI-9917-2020
FU National Research Foundation of Korea (NRF) grant - Korea government
   (MSIP) [2014R1A1A1006144]
FX This study was supported by the National Research Foundation of Korea
   (NRF) grant funded by the Korea government (MSIP, 2014R1A1A1006144).
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NR 61
TC 11
Z9 11
U1 0
U2 6
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0021-9150
EI 1879-1484
J9 ATHEROSCLEROSIS
JI Atherosclerosis
PD JAN
PY 2016
VL 244
BP 204
EP 210
DI 10.1016/j.atherosclerosis.2015.11.008
PG 7
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA CZ8UR
UT WOS:000367375100067
PM 26684255
DA 2025-06-11
ER

PT J
AU Karamouzis, I
   Pervanidou, P
   Berardelli, R
   Iliadis, S
   Papassotiriou, I
   Karamouzis, M
   Chrousos, GP
   Kanaka-Gantenbein, C
AF Karamouzis, I.
   Pervanidou, P.
   Berardelli, R.
   Iliadis, S.
   Papassotiriou, I.
   Karamouzis, M.
   Chrousos, G. P.
   Kanaka-Gantenbein, C.
TI Enhanced Oxidative Stress and Platelet Activation Combined with Reduced
   Antioxidant Capacity in Obese Prepubertal and Adolescent Girls with Full
   or Partial Metabolic Syndrome
SO HORMONE AND METABOLIC RESEARCH
LA English
DT Article
DE antioxidant state; isoprostane; thromboxane; pediatric obesity; carbonyl
   proteins
ID INTIMA-MEDIA THICKNESS; PROTEIN-KINASE-C; ALPHA-TOCOPHEROL;
   INSULIN-RESISTANCE; BETA-CAROTENE; CARDIOVASCULAR-DISEASE;
   LIPID-PEROXIDATION; OXIDANT STRESS; ISOPROSTANES; THROMBOXANE
AB In adults, obesity is a main factor implicated in increased oxidative stress (OS), platelet activation (PA) and impaired antioxidant status (AS), all predisposing factors for cardiovascular disease leading to increased morbidity and mortality. Furthermore, the metabolic syndrome (MetS) is an important cardiovascular risk factor, which progressively develops and may already be present during late childhood or adolescence. However, scarce data exist on oxidative-antioxidant balance and PA in childhood and adolescence in the presence of partial (PMetS) or full MetS. The aim of the study was to evaluate OS, PA, and AS in prepubertal and adolescent obese girls with partial or full MetS. 96 girls with a clinical and metabolic evaluation for obesity and 44 healthy normal-weight sex-and age-matched girls were studied. IDF-adopted criteria were used to define full and partial MetS and the patient population was divided into 4 groups: the first comprised 31 pre-pubertal girls with PMetS (PR-PMetS), the second 37 adolescents with PMetS (AD-PMetS), the third 10 prepubertal girls with full MetS (PR-MetS), and the fourth 18 adolescents with full MetS (AD-MetS). The OS was evaluated by measuring plasma 15-F-2t-Isoprostane levels (15-F-2t-IsoP) and protein carbonyls, PA by thromboxane B-2 levels (TXB2), and AS by serum vitamin E and plasma total antioxidant capacity (TAC) levels. 15-F-2t-IsoP, protein carbonyls, and TXB2 levels were significantly gradually amplified, and vitamin E and TAC reduced, and significantly correlated with obesity from childhood to adolescence and from partial to full MetS. This study demonstrates the loss of the normal homeostatic balance between oxidant-antioxidant state in obese children and adolescents with manifestations of partial and full MetS.
C1 [Karamouzis, I.; Pervanidou, P.; Chrousos, G. P.; Kanaka-Gantenbein, C.] Univ Athens, Sch Med, Aghia Sophia Childrens Hosp, Div Endocrinol Diabet & Metab,Dept Pediat 1, GR-11527 Athens, Greece.
   [Berardelli, R.] Univ Turin, Dept Internal Med, Div Endocrinol Diabet & Metab, I-10124 Turin, Italy.
   [Iliadis, S.; Karamouzis, M.] Aristotle Univ Thessaloniki, Biol Chem Lab, Fac Med, Thessaloniki, Greece.
   [Papassotiriou, I.] Aghia Sophia Childrens Hosp, Dept Clin Biochem, Athens, Greece.
C3 Athens Medical School; The Aghia Sophia Children's Hospital; National &
   Kapodistrian University of Athens; University of Turin; Aristotle
   University of Thessaloniki; The Aghia Sophia Children's Hospital
RP Kanaka-Gantenbein, C (corresponding author), Thivon & Papadiamantopoulou Goudi, Athens 11527, Greece.
EM ganten@hol.gr
RI Kanaka-Gantenbein, Christina/AAP-3697-2020; Pervanidou,
   Panagiota/ABI-6356-2020
OI Pervanidou, Panagiota/0000-0002-6593-6489; ILIADIS,
   STAVROS/0000-0001-6671-1401
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NR 62
TC 35
Z9 38
U1 0
U2 4
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0018-5043
EI 1439-4286
J9 HORM METAB RES
JI Horm. Metab. Res.
PD AUG
PY 2011
VL 43
IS 9
BP 607
EP 613
DI 10.1055/s-0031-1284355
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 803IJ
UT WOS:000293574700003
PM 21823055
DA 2025-06-11
ER

PT J
AU Kopp, W
AF Kopp, Wolfgang
TI How Western Diet And Lifestyle Drive The Pandemic Of Obesity And
   Civilization Diseases
SO DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
LA English
DT Article
DE diabetes; obesity; metabolic syndrome; insulin hypersecretion; oxidative
   stress; paleolithic diet; pathogenesis
ID RENIN-ANGIOTENSIN SYSTEM; SYMPATHETIC-NERVOUS-SYSTEM; INDUCED
   INSULIN-RESISTANCE; POLYCYSTIC-OVARY-SYNDROME; OXIDATIVE STRESS;
   HIGH-FAT; ENDOTHELIAL DYSFUNCTION; METABOLIC SYNDROME; CHRONIC
   INFLAMMATION; CIGARETTE-SMOKING
AB Westernized populations are plagued by a plethora of chronic non-infectious degenerative diseases, termed as "civilization diseases", like obesity, diabetes, cardiovascular diseases, cancer, autoimmune diseases, Alzheimer's disease and many more, diseases which are rare or virtually absent in hunter-gatherers and other non-westernized populations. There is a growing awareness that the cause of this amazing discrepancy lies in the profound changes in diet and lifestyle during recent human history. This paper shows that the transition from Paleolithic nutrition to Western diets, along with lack of corresponding genetic adaptations, cause significant distortions of the fine-tuned metabolism that has evolved over millions of years of human evolution in adaptation to Paleolithic diets. With the increasing spread of Western diet and lifestyle worldwide, overweight and civilization diseases are also rapidly increasing in developing countries. It is suggested that the diet-related key changes in the developmental process include an increased production of reactive oxygen species and oxidative stress, development of hyperinsulinemia and insulin resistance, low-grade inflammation and an abnormal activation of the sympathetic nervous system and the renin-angiotensin system, all of which play pivotal roles in the development of diseases of civilization. In addition, diet-related epigenetic changes and fetal programming play an important role. The suggested pathomechanism is also able to explain the well-known but not completely understood close relationship between obesity and the wide range of comorbidities, like type 2 diabetes mellitus, cardiovascular disease, etc., as diseases of the same etiopathology. Changing our lifestyle in accordance with our genetic makeup, including diet and physical activity, may help prevent or limit the development of these diseases.
C1 [Kopp, Wolfgang] Diagnost Zentrum Graz, A-8043 Graz, Austria.
RP Kopp, W (corresponding author), Mariatrosterstr 41, A-8043 Graz, Austria.
EM w.kopp@weiz.cc
OI Kopp, Wolfgang/0000-0002-8869-5470
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NR 198
TC 448
Z9 496
U1 7
U2 109
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-7007
J9 DIABET METAB SYND OB
JI Diabetes Metab. Syndr. Obes.
PY 2019
VL 12
BP 2221
EP 2236
DI 10.2147/DMSO.S216791
PG 16
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA JG6OT
UT WOS:000492191400001
PM 31695465
OA gold, Green Published
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Basile, U
   Bruno, C
   Napodano, C
   Vergani, E
   Pocino, K
   Brunetti, A
   Gulli, F
   Santini, SA
   Mancini, A
AF Basile, Umberto
   Bruno, Carmine
   Napodano, Cecilia
   Vergani, Edoardo
   Pocino, Krizia
   Brunetti, Alessandro
   Gulli, Francesca
   Santini, Stefano Angelo
   Mancini, Antonio
TI Plasmatic free light chains as inflammatory marker in insulin
   resistance: comparison of metabolic syndrome with adult growth hormone
   deficiency
SO BIOFACTORS
LA English
DT Article
DE inflammation; immunoglobulines; personalized medicine; oxidative stress;
   antioxidants
ID OXIDATIVE STRESS; BLOOD-PRESSURE; MAST-CELLS; SERUM; KAPPA;
   INTERLEUKIN-6; PATHOGENESIS; CAPACITY; IGF-1
AB Biological functions of immunoglobulin-free light chains (FLCs), other than in chronic inflammatory diseases, are still poorly defined; the field of insulin resistance (IR) has not been investigated, despite the strict relationships with oxidative stress (OS) and inflammation. Therefore, we evaluated FLCs levels and their relationships with metabolic parameters in adult growth hormone deficiency (GHD) and metabolic syndrome (MetS), both characterized by IR. One hundred subjects were enrolled: group A, patients with GHD [n = 31, 24-69 years, mean +/- SEM body mass index (BMI) 26.8 +/- 1.5 kg/m(2)]; group B, patients with MetS (n = 29, 21-70 years, BMI 31.9 +/- 1.3); group C, controls (N = 40, 21-62 years, BMI 21.6 +/- 1.1). Groups were matched by age range and, for patients, by BMI. Morning blood sample was collected for metabolic parameters and FLCs, assessed by turbidimetric assay. GHD patients show levels of FLCs significantly higher than MetS and controls (mean +/- SEM kappa 37.21 +/- 6.97, 15.27 +/- 0.86, 12.34 +/- 0.85 mg/l; lambda 19.44 +/- 2.61, 11.78 +/- 0.72 and 11.67 +/- 0.77 mg/l; kappa/lambda ratio 1.77 +/- 0.13, 1.38 +/- 0.09; and 1.10 +/- 0.06, respectively); only kappa were higher in MetS versus controls. Therefore, the ratio showed progressive declining values in GHD versus MetS versus controls. Our data show increased FLCs levels in GHD and MetS, with the highest values in the former. Both conditions show OS, but with different molecular patterns. FLCs may contribute to chronic inflammation, leading to OS, and cardiovascular complications of GHD. Prognostic and therapeutic implications require further investigation. (C) 2018 BioFactors
C1 [Basile, Umberto] Fdn Policlin Univ A Gemelli IRCCS, Dept Lab Med, Rome, Italy.
   [Bruno, Carmine; Vergani, Edoardo; Brunetti, Alessandro; Mancini, Antonio] Univ Cattolica Sacro Cuore, Fdn Policlin Univ A Gemelli IRCCS, Operat Unit Endocrinol, Rome, Italy.
   [Napodano, Cecilia; Pocino, Krizia] Univ Cattolica Sacro Cuore, Fdn Policlin Univ A Gemelli IRCCS, Dept Internal Med, Rome, Italy.
   [Gulli, Francesca] Osped MG Vannini, Rome, Italy.
   [Santini, Stefano Angelo] Univ Cattolica Sacro Cuore, Fdn Policlin Univ A Gemelli IRCCS, Inst Biochem & Clin Biochem, Rome, Italy.
C3 Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli;
   Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli;
   Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli;
   Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli
RP Mancini, A (corresponding author), Largo A Gemelli 8, I-00168 Rome, Italy.
EM antonio.mancini@unicatt.it
RI Bruno, Carmine/CAA-0347-2022; Vergani, Edoardo/JCE-0461-2023; Napodano,
   Cecilia/AAO-6048-2020; Brunetti, Alessandro/HKF-8508-2023; basile,
   umberto/E-1720-2018
OI mancini, antonio/0000-0002-9417-6810; Brunetti,
   Alessandro/0000-0001-6651-4117; Napodano, Cecilia/0000-0002-8720-6284;
   Vergani, Edoardo/0000-0002-8444-0091; basile,
   umberto/0000-0002-8328-2570; Bruno, Carmine/0000-0002-3489-0238
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NR 34
TC 15
Z9 15
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0951-6433
EI 1872-8081
J9 BIOFACTORS
JI Biofactors
PD SEP-OCT
PY 2018
VL 44
IS 5
BP 480
EP 484
DI 10.1002/biof.1444
PG 5
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA GY2JC
UT WOS:000448367400007
PM 30175865
DA 2025-06-11
ER

PT J
AU Zilli, AMH
   Zilli, EM
AF Zilli, Aline M. Hilzendeger
   Zilli, Eduardo M.
TI Review of Evidence and Perspectives of Flavonoids on Metabolic Syndrome
   and Neurodegenerative Disease
SO PROTEIN AND PEPTIDE LETTERS
LA English
DT Review
DE Flavonoids; antioxidant; anti-inflammatory; metabolic syndrome; obesity;
   gut microbiota; dementia
ID LOW-GRADE INFLAMMATION; GUT MICROBIOTA; IN-VITRO; INTESTINAL
   INFLAMMATION; DIETARY FLAVONOIDS; ENERGY-EXPENDITURE; COGNITIVE
   FUNCTION; PHENOLIC-ACIDS; BLOOD-PRESSURE; IMMUNE-SYSTEM
AB Flavonoids are commonly found in fruits, vegetables, and plant-derived foods and may promote various health benefits when included in the diet. The biological activity of flavonoids is normally associated to their potent antioxidant and anti-inflammatory effects, since oxidative stress is associated to conditions such as diabetes, obesity, cardiovascular and neurodegenerative diseases. Additionally, flavonoids may be related to metabolic diseases through their effects on inflammatory mediators and pathways, barrier integrity and gut microbiota composition. The extensive metabolism undergone by flavonoids in humans and the individual differences in their bioavailability to target organs hinder the interpretation of results from cell and animal models. Prospective human studies therefore provide an important perspective. In the field of neurodegenerative disease, carefully designed cohort studies have uncovered important associations between flavonoid intake and reduction in dementia risk, especially regarding specific flavonols, but also anthocyanins. Alternative mechanisms of action, such as changes in the gut microbiota or modulation of the production of toxic proteins, such as amyloid and tau, likely account for an important component of their positive effects, and their elucidation may lead to public health benefits of large magnitude.
C1 [Zilli, Aline M. Hilzendeger; Zilli, Eduardo M.] Univ Texas San Antonio, Hlth & Sci Ctr, Glenn Biggs Inst Alzheimer & Neurodegenerat Dis, San Antonio, TX 78229 USA.
C3 University of Texas System; University of Texas Health Science Center at
   San Antonio
RP Zilli, EM (corresponding author), Univ Texas San Antonio, Hlth & Sci Ctr, Glenn Biggs Inst Alzheimer & Neurodegenerat Dis, San Antonio, TX 78229 USA.
EM marqueszilli@uthscsa.edu
OI Marques Zilli, Eduardo/0000-0002-6743-8379
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NR 91
TC 5
Z9 5
U1 1
U2 25
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 0929-8665
EI 1875-5305
J9 PROTEIN PEPTIDE LETT
JI Protein Pept. Lett.
PY 2021
VL 28
IS 7
BP 725
EP 734
DI 10.2174/0929866528666210127152359
PG 10
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA TZ5PC
UT WOS:000684523300002
PM 33504293
DA 2025-06-11
ER

PT J
AU Teixeira, CJ
   Veras, K
   Carvalho, CRD
AF Teixeira, Caio Jordao
   Veras, Katherine
   de Oliveira Carvalho, Carla Roberta
TI Dehydroepiandrosterone on metabolism and the cardiovascular system in
   the postmenopausal period
SO JOURNAL OF MOLECULAR MEDICINE-JMM
LA English
DT Review
DE Dehydroepiandrosterone; Menopause; Adiposity; Insulin resistance;
   Metabolic syndrome; Cardiovascular disease
ID ELEVATED HEPATIC GLUCOSE-6-PHOSPHATASE; CAROTID-ARTERY DISTENSIBILITY;
   STIMULATED INSULIN-SECRETION; URINARY ALBUMIN EXCRETION;
   PROTEIN-KINASE-C; OXIDATIVE STRESS; GLUCOSE-UPTAKE; IN-VITRO; ORAL
   DEHYDROEPIANDROSTERONE; REPLACEMENT THERAPY
AB Dehydroepiandrosterone (DHEA), mostly present as its sulfated ester (DHEA-S), is an anabolic hormone that naturally declines with age. Furthermore, it is the most abundant androgen and estrogen precursor in humans. Low plasma levels of DHEA have been strongly associated with obesity, insulin resistance, dyslipidemia, and high blood pressure, increasing the risk of cardiovascular disease. In this respect, DHEA could be regarded as a promising agent against metabolic syndrome (MetS) in postmenopausal women, since several age-related metabolic diseases are reported during aging. There are plenty of experimental evidences showing beneficial effects after DHEA therapy on carbohydrate and lipid metabolism, as well as cardiovascular health. However, its potential as a therapeutic agent appears to attract controversy, due to the lack of effects on some symptoms related to MetS. In this review, we examine the available literature regarding the impact of DHEA therapy on adiposity, glucose metabolism, and the cardiovascular system in the postmenopausal period. Both clinical studies and in vitro and in vivo experimental models were selected, and where possible, the main cellular mechanisms involved in DHEA therapy were discussed.
C1 [Teixeira, Caio Jordao] Univ Estadual Campinas, Fac Med Sci, Dept Pharmacol, 105 Alexander Fleming St, BR-13083881 Campinas, SP, Brazil.
   [Teixeira, Caio Jordao; de Oliveira Carvalho, Carla Roberta] Univ Sao Paulo, Dept Physiol & Biophys, Inst Biomed Sci, 1524 Prof Lineu Prestes Ave,ICB 1, BR-05508900 Sao Paulo, SP, Brazil.
   [Veras, Katherine] Univ Mogi das Cruzes, Dept Nutr, 200 Dr Candido XA Souza Ave, BR-08780911 Sao Paulo, SP, Brazil.
C3 Universidade Estadual de Campinas; Universidade de Sao Paulo;
   Universidade de Mogi das Cruzes
RP Carvalho, CRD (corresponding author), Univ Sao Paulo, Dept Physiol & Biophys, Inst Biomed Sci, 1524 Prof Lineu Prestes Ave,ICB 1, BR-05508900 Sao Paulo, SP, Brazil.
EM croc@icb.usp.br
RI VERAS, KATHERINE/HTS-8114-2023; Carvalho, Carla/H-6476-2018; Jordao
   Teixeira, Caio/D-5685-2018
OI Veras, Katherine/0000-0003-2658-8618; Carvalho,
   Carla/0000-0001-5824-8656; Jordao Teixeira, Caio/0000-0002-4951-1130
FU Brazilian research agency: Coordenacao de Aperfeicoamento de Pessoal de
   Nivel Superior (CAPES) [001]; Brazilian research agency: Fundacao de
   Amparo a Pesquisa do Estado de Sao Paulo [FAPESP-2012/14183-7];
   Brazilian research agency: Conselho Nacional de Desenvolvimento
   Cientifico e Tecnologico [CNPq-303543/2014-0]
FX This study was supported by grants from the Brazilian research agencies:
   Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior
   (CAPES-Finance Code 001), Fundacao de Amparo a Pesquisa do Estado de Sao
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NR 188
TC 20
Z9 20
U1 0
U2 10
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0946-2716
EI 1432-1440
J9 J MOL MED
JI J. Mol. Med.
PD JAN
PY 2020
VL 98
IS 1
BP 39
EP 57
DI 10.1007/s00109-019-01842-5
EA NOV 2019
PG 19
WC Genetics & Heredity; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Genetics & Heredity; Research & Experimental Medicine
GA KJ2BH
UT WOS:000495980700001
PM 31713639
DA 2025-06-11
ER

PT J
AU Kheirbakhsh, R
   Haddadi, M
   Muhammadnejad, A
   Abdollahi, A
   Shahi, F
   Amanpour-Gharaei, B
   Abrahim-Habibi, A
   Barati, T
   Amanpour, S
AF Kheirbakhsh, Raheleh
   Haddadi, Mahnaz
   Muhammadnejad, Ahad
   Abdollahi, Alireza
   Shahi, Farshad
   Amanpour-Gharaei, Behzad
   Abrahim-Habibi, Azadeh
   Barati, Tahereh
   Amanpour, Saeid
TI Long-term behavioral, histological, biochemical and hematological
   evaluations of amyloid beta-induced Alzheimer's disease in rat
SO ACTA NEUROBIOLOGIAE EXPERIMENTALIS
LA English
DT Article
DE Alzheimer's disease; amyloid beta; animal model; long-term evaluation
ID MEMORY IMPAIRMENT; OXIDATIVE STRESS; LIPID-PEROXIDATION;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; BRAIN; RISK; DIAGNOSIS; PEPTIDE;
   GLUCOSE
AB Alzheimer's disease (AD) is a mental impairment and neural degeneration which causes progressive loss of memory and cognitive functions. This age-dependent illness is associated with extracellular amyloid plaques accumulation and twisted neurofibrillary tangles. Amyloid plaques are experimentally generated in animal models in order to investigate the disease process. In this study, we followed a rat model of AD for over a year. Wistar rats were divided randomly into two groups as control group (surgery without injection An), and experimental group (two-sided intrahippocampal amyloid-beta injection into hippocampus). From each group, three animals were investigated 42 days after injection, and the remaining four animals were studied after one year. All animals were tested for learning abilities and memory. Finally, samples from blood, brain, heart, kidney, liver, colon and spleen were examined. In the experimental group, the size of amyloid plaques were increased significantly after one year and learning abilities and memory were concomitantly decreased. Onsets of various other conditions such as liver and kidney disorders, diabetes, and metabolic syndrome were observed, which indicates that the animals may be prone to cardiovascular disorders and ischemia.
C1 [Kheirbakhsh, Raheleh; Muhammadnejad, Ahad; Barati, Tahereh; Amanpour, Saeid] Univ Tehran Med Sci, Canc Res Inst Iran, Canc Biol Res Ctr, Tehran, Iran.
   [Haddadi, Mahnaz] Univ Tehran Med Sci, Vali E Asr Reprod Hlth Res Ctr, Tehran, Iran.
   [Abdollahi, Alireza] Univ Tehran Med Sci, Sch Med, Dept Pathol, Imam Khomeini Hosp Complex, Tehran, Iran.
   [Shahi, Farshad] Islamic Azad Univ, Tehran Med Branch, Tehran, Iran.
   [Amanpour-Gharaei, Behzad] Univ Tehran Med Sci, Res Ctr Mol & Cellular imaging, Neuroimaging & Anal Grp, Tehran, Iran.
   [Amanpour-Gharaei, Behzad] Ruhr Univ, Int Grad Sch Neurosci, Bochum, Germany.
   [Abrahim-Habibi, Azadeh] Univ Tehran Med Sci, Endocrinol & Metab Mol Cellular Sci Inst, Biosensor Res Ctr, Tehran, Iran.
C3 Tehran University of Medical Sciences; Tehran University of Medical
   Sciences; Tehran University of Medical Sciences; Islamic Azad
   University; Tehran University of Medical Sciences; Ruhr University
   Bochum; Tehran University of Medical Sciences
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EM Amanpour_s@tums.ac.ir
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NR 65
TC 7
Z9 7
U1 0
U2 9
PU NENCKI INST EXPERIMENTAL BIOLOGY
PI WARSAW
PA UL PASTEURA 3, 02-093 WARSAW, POLAND
SN 0065-1400
EI 1689-0035
J9 ACTA NEUROBIOL EXP
JI Acta Neurobiol. Exp.
PY 2018
VL 78
IS 1
BP 51
EP 59
DI 10.21307/ane-2018-004
PG 9
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA GF4IH
UT WOS:000431925900006
PM 29694341
OA gold
DA 2025-06-11
ER

PT J
AU Talbot, S
   Dias, JP
   El Midaoui, A
   Couture, R
AF Talbot, Sebastien
   Dias, Jenny Pena
   El Midaoui, Adil
   Couture, Rejean
TI Beneficial effects of kinin B1 receptor antagonism on plasma fatty acid
   alterations and obesity in Zucker diabetic fatty rats
SO CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
LA English
DT Article
DE fatty acids; kinin B1 receptor; metabolic syndrome; obesity; SSR240612;
   type 2 diabetes; Zucker diabetic fatty rat
ID INSULIN-RESISTANT RATS; ALPHA-LIPOIC ACID; NERVE BLOOD-FLOW; OXIDATIVE
   STRESS; B-1 RECEPTOR; SENSORY ABNORMALITIES; NOCICEPTIVE BEHAVIOR;
   MODEL; BRADYKININ; MELLITUS
AB Kinins are the endogenous ligands of the constitutive B2 receptor (B2R) and the inducible B1 receptor (B1R). Whereas B2R prevents insulin resistance, B1R is involved in insulin resistance and metabolic syndrome. However, the contribution of B1R in type 2 diabetes associated with obesity remains uncertain. The aim of the present study was to examine the impact of 1-week treatment with a selective B1R antagonist (SSR240612, 10 mg/kg per day, by gavage) on hyperglycemia, hyperinsulinemia, leptinemia, body mass gain, and abnormal plasma fatty acids in obese Zucker diabetic fatty (ZDF) rats. Treatment with SSR240612 abolished the body mass gain and reduced polyphagia, polydipsia, and plasma fatty acid alterations in ZDF rats without affecting hyperglycemia, hyperinsulinemia, and hyperleptinemia. The present study suggests that the upregulated B1R plays a role in body mass gain and circulating fatty acid alterations in ZDF rats. However, mechanisms other than B1R induction would be implicated in glucose metabolism disorder in ZDF rats, based on the finding that SSR240612 did not reverse hyperglycemia and hyperinsulinemia.
C1 [Talbot, Sebastien; Dias, Jenny Pena; El Midaoui, Adil; Couture, Rejean] Univ Montreal, Fac Med, Dept Mol & Integrat Physiol, Stn City Ctr, POB 6128, Montreal, PQ H3C 3J7, Canada.
C3 Universite de Montreal
RP Couture, R (corresponding author), Univ Montreal, Fac Med, Dept Mol & Integrat Physiol, Stn City Ctr, POB 6128, Montreal, PQ H3C 3J7, Canada.
EM rejean.couture@umontreal.ca
OI Talbot, Sebastien/0000-0001-9932-7174
FU Canadian Institutes of Health Research (CIHR) [MOP-119329]; CIHR
FX This work was supported by a Grant-in-Aid from the Canadian Institutes
   of Health Research (CIHR) (MOP-119329) to RC. ST and JPD were recipients
   of Studentship Awards from the CIHR (Frederick Banting and Charles Best
   Canada Graduate Scholarships Doctoral Award). We are most grateful to
   Dr. Emile Levy's laboratory (Department of Nutrition, Ste-Justine
   Research Center, Universite de Montreal) for the measurement of plasma
   fatty acids and to Jacques Senecal for his technical assistance.
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NR 40
TC 13
Z9 13
U1 0
U2 5
PU CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS
PI OTTAWA
PA 65 AURIGA DR, SUITE 203, OTTAWA, ON K2E 7W6, CANADA
SN 0008-4212
EI 1205-7541
J9 CAN J PHYSIOL PHARM
JI Can. J. Physiol. Pharmacol.
PD JUL
PY 2016
VL 94
IS 7
BP 752
EP 757
DI 10.1139/cjpp-2016-0063
PG 6
WC Pharmacology & Pharmacy; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Physiology
GA DQ0YG
UT WOS:000378927100010
PM 27172260
DA 2025-06-11
ER

PT J
AU Bautista-Expósito, S
   Martínez-Villaluenga, C
   Dueñas, M
   Silván, JM
   Frias, J
   Peñas, E
AF Bautista-Exposito, Sara
   Martinez-Villaluenga, Cristina
   Duenas, Montserrat
   Manuel Silvan, Jose
   Frias, Juana
   Penas, Elena
TI Combination of pH-controlled fermentation in mild acidic conditions and
   enzymatic hydrolysis by Savinase to improve metabolic health-promoting
   properties of lentil
SO JOURNAL OF FUNCTIONAL FOODS
LA English
DT Article
DE Lentil; pH-controlled fermentation; Lactobacillus plantarum; Savinase;
   Bioactivity; Metabolic syndrome
ID I-CONVERTING-ENZYME; SIMULATED GASTROINTESTINAL DIGESTION; GLUCOSIDASE
   INHIBITORY-ACTIVITY; LOW-DENSITY-LIPOPROTEIN; ALPHA-GLUCOSIDASE;
   ANTIOXIDANT ACTIVITIES; PHENOLIC-COMPOUNDS; OXIDATIVE STRESS;
   ANTIINFLAMMATORY ACTIVITIES; POLYPHENOLIC COMPOUNDS
AB This work evaluated the feasibility of pH-controlled fermentation by Lactobacillus plantarum CECT 748 combined with Savinase-hydrolysis (LPHS) for producing multifunctional lentil ingredients targeted for metabolic syndrome (MetS) relieving. LPHS process was compared with L. plantarum-fermentation (LP) and Savinase-hydrolysis (HS), applied separately. LPHS soluble fraction exhibited higher peptides, p-hydroxybenzoic acid, flavonols, antioxidant (400.74 mM TE/g), angiotensin I-converting enzyme (ACE) (95.43%) and alpha-glucosidase-inhibitory activities (40.55 and 25.03% for maltase and sacarase activities, respectively) than LP and HS. L. plantarum was responsible for the phenolic profile changes and sucrase inhibitory activity of LPHS while Savinase contributed to peptides release and ACE and maltase inhibitory and antioxidant activities. The most active LPHS fraction contained 3 peptides with potential biological activity and flavonoids and phenolic acids. LPHS simulated gastrointestinal digestion enhanced its peptides, phenolics, ACE-inhibitory and antioxidant activities. This study opens new opportunities regarding the production of lentil-multifunctional ingredients for MetS management.
C1 [Bautista-Exposito, Sara; Martinez-Villaluenga, Cristina; Manuel Silvan, Jose; Frias, Juana; Penas, Elena] CSIC, ICTAN, Inst Food Sci Technol & Nutr, Juan de la Cierva 3, Madrid 28006, Spain.
   [Duenas, Montserrat] Univ Salamanca, Fac Pharm, Nutr & Bromatol Unit, Res Grp Polyphenols, Campus Miguel Unamuno, Salamanca 37007, Spain.
C3 Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Instituto
   de Ciencia y Tecnologia de Alimentos y Nutricion (ICTAN); University of
   Salamanca
RP Peñas, E (corresponding author), CSIC, ICTAN, Inst Food Sci Technol & Nutr, Juan de la Cierva 3, Madrid 28006, Spain.
EM elenape@ictan.csic.es
RI Dueñas, M./A-8976-2016; Peñas, Elena/C-8557-2015; Martinez-Villaluenga,
   Cristina/AAK-7199-2021; Silvan Jimenez, Jose Manuel/F-3032-2013; Frias,
   Juana/F-6607-2013
OI Silvan Jimenez, Jose Manuel/0000-0001-8266-3761; Frias,
   Juana/0000-0003-0355-3113; Bautista Exposito, Sara/0000-0002-9099-2247
FU Ministry of Economy and Competitiveness (MINECO, Spain); FEDER program
   [AGL2013-43247-R]; MINECO; European Social Fund
FX The research leading to these results received funding from Ministry of
   Economy and Competitiveness (MINECO, Spain) and FEDER program (grant
   number AGL2013-43247-R). E. P. acknowledges to MINECO and European
   Social Fund for her "Ramon y Cajal" contract.
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NR 69
TC 15
Z9 17
U1 1
U2 22
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1756-4646
J9 J FUNCT FOODS
JI J. Funct. Food.
PD SEP
PY 2018
VL 48
BP 9
EP 18
DI 10.1016/j.jff.2018.06.019
PG 10
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA GX2TS
UT WOS:000447573600002
OA Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Burke, V
AF Burke, Valerie
TI Obesity in childhood and cardiovascular risk
SO CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
LA English
DT Article; Proceedings Paper
CT Joint Meeting of the
   Australian-Physiological-Society/Australian-Biophysics-Society
CY DEC 06-07, 2005
CL Melbourne, AUSTRALIA
SP Australian Physiol Soc, Australian Biophys Soc
DE blood pressure; child; lipids; metabolic syndrome; obesity
ID BODY-MASS INDEX; HEALTH-RELATED BEHAVIORS; PHYSICAL-ACTIVITY;
   YOUNG-ADULTS; AUSTRALIAN CHILDREN; BLOOD-PRESSURE; FOLLOW-UP; OVERWEIGHT
   CHILDREN; INSULIN-RESISTANCE; DIABETES-MELLITUS
AB Childhood obesity is increasing worldwide and is associated with an increase in cardiovascular risk factors in childhood.
   In children, obesity is associated with hypertension, impaired vascular function, dyslipidaemia, atheroma, the metabolic syndrome, type 2 diabetes, systemic inflammation and oxidative stress. Greater risk is associated with clustering of risk factors.
   Obesity tracks from childhood to adult life and predicts adverse levels of risk and an increase in cardiovascular end-points.
   Adults who were obese as children have higher rates of obesity and its sequelae: greater intima-media thickness, left ventricular hypertrophy and atherosclerosis. There is greater all-cause and cardiovascular mortality, as well as a greater risk of stroke, in long-term follow-up of obese children.
   Genetic and environmental factors contribute to familial aggregation of obesity, with parental obesity as a strong predictor of obesity in children. However, clustering of adverse health-related behaviours is seen in such families.
   Adverse behaviours (smoking, poor dietary choices, less physical activity and greater alcohol intake) also cluster in individuals, suggesting the need for multimodal interventions.
   Recognition of families at risk offers opportunities for prevention of obesity in children and decreasing risk in parents.
C1 Univ Western Australia, Sch Med & Pharmacol, Royal Perth Hosp Unit, Perth, WA 6847, Australia.
   Cardiovasc Res Ctr, Perth, WA, Australia.
C3 University of Western Australia; East Metropolitan Health Service; Royal
   Perth Hospital
RP Burke, V (corresponding author), Univ Western Australia, Sch Med & Pharmacol, Royal Perth Hosp Unit, POB X2213, Perth, WA 6847, Australia.
EM vburke@cyllene.uwa.edu.au
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NR 78
TC 66
Z9 90
U1 0
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0305-1870
EI 1440-1681
J9 CLIN EXP PHARMACOL P
JI Clin. Exp. Pharmacol. Physiol.
PD SEP
PY 2006
VL 33
IS 9
BP 831
EP 837
DI 10.1111/j.1440-1681.2006.04449.x
PG 7
WC Pharmacology & Pharmacy; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Pharmacology & Pharmacy; Physiology
GA 072FM
UT WOS:000239659300013
PM 16922816
DA 2025-06-11
ER

PT J
AU Jarmakiewicz-Czaja, S
   Sokal, A
   Pardak, P
   Filip, R
AF Jarmakiewicz-Czaja, Sara
   Sokal, Aneta
   Pardak, Piotr
   Filip, Rafal
TI Glucocorticosteroids and the Risk of NAFLD in Inflammatory Bowel Disease
SO CANADIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
LA English
DT Review
ID FATTY LIVER-DISEASE; ANTI-SACCHAROMYCES-CEREVISIAE; METABOLIC SYNDROME;
   PHYSICAL-ACTIVITY; HEPATIC STEATOSIS; CARDIORESPIRATORY FITNESS;
   AMINOTRANSFERASE LEVELS; INSULIN-RESISTANCE; BARIATRIC SURGERY;
   OXIDATIVE STRESS
AB Each year, the incidence of nonalcoholic fatty liver (NAFLD) disease increases. NAFLD is a chronic disease. One of the most common causes of NAFLD is an inadequate lifestyle, which is characterized by a lack or low physical activity and eating highly processed foods rich in saturated fat and salt and containing low amount of fiber. Moreover, disturbances in intestinal microbiome and the use of certain drugs may predispose to NAFLD. NAFLD is an increasingly described disease in patients with inflammatory bowel disease (IBD). Recent data also indicate a frequent coexistence of metabolic syndrome in this group of patients. Certain groups of drugs also increase the risk of developing inflammation, liver fibrosis, and cirrhosis. Particularly important in the development of NAFLD are steroids, which are used in the treatment of many diseases, for example, IBD. NAFLD is one of the most frequent parenteral manifestations of the disease in IBD patients. However, there is still insufficient information on what dose and exposure time of selected types of steroids may lead to the development of NAFLD. It is necessary to conduct further research in this direction. Therefore, patients with IBD should be constantly monitored for risk factors for the development of NAFLD.
C1 [Jarmakiewicz-Czaja, Sara; Sokal, Aneta] Rzeszow Univ, Inst Hlth Sci, Med Coll, PL-35959 Rzeszow, Poland.
   [Pardak, Piotr; Filip, Rafal] Rzeszow Univ, Inst Med, Med Coll, PL-35959 Rzeszow, Poland.
   [Pardak, Piotr; Filip, Rafal] Clin Hosp, Dept Gastroenterol, IBD Unit, 2, PL-35301 Rzeszow, Poland.
C3 University of Rzeszow; University of Rzeszow
RP Filip, R (corresponding author), Rzeszow Univ, Inst Med, Med Coll, PL-35959 Rzeszow, Poland.; Filip, R (corresponding author), Clin Hosp, Dept Gastroenterol, IBD Unit, 2, PL-35301 Rzeszow, Poland.
EM sjczaja@ur.edu.pl; asokal@ur.edu.pl; piotrpardak@wp.pl; r.s.filip@wp.pl
RI Sokal-Dembowska, Aneta/KZU-3915-2024; Jarmakiewicz - Czaja,
   Sara/AFT-7035-2022; Filip, Rafal/O-4277-2019
OI Sokal-Dembowska, Aneta/0000-0003-4727-8766; Jarmakiewicz-Czaja,
   Sara/0000-0001-6896-4744
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NR 149
TC 8
Z9 8
U1 0
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2291-2789
EI 2291-2797
J9 CAN J GASTROENTEROL
JI Can. J. Gastroenterol. Hepatol.
PD MAY 11
PY 2022
VL 2022
AR 4344905
DI 10.1155/2022/4344905
PG 13
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 1S3GV
UT WOS:000803943600002
PM 35600209
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Leibold, S
   Lakshminarasimha, AB
   Gremse, F
   Hammerschmidt, M
   Michel, M
AF Leibold, Sandra
   Lakshminarasimha, Amrutha Bagivalu
   Gremse, Felix
   Hammerschmidt, Matthias
   Michel, Maximilian
TI Long-term obesogenic diet leads to metabolic phenotypes which are not
   exacerbated by catch-up growth in zebrafish
SO PLOS ONE
LA English
DT Article
ID COMPENSATORY GROWTH; ENERGY-EXPENDITURE; OXIDATIVE STRESS; INDUCED
   OBESITY; PRETERM BIRTH; INFANCY; LIFE; DEFICIENCY; DEPOSITION;
   RESISTANCE
AB Obesity and metabolic syndrome are of increasing global concern. In order to understand the basic biology and etiology of obesity, research has turned to animals across the vertebrate spectrum including zebrafish. Here, we carefully characterize zebrafish in a long-term obesogenic environment as well as zebrafish that went through early lifetime caloric restriction. We found that long-term obesity in zebrafish leads to metabolic endpoints comparable to mammals including increased adiposity, weight, hepatic steatosis and hepatic lesions but not signs of glucose dysregulation or differences in metabolic rate or mitochondrial function. Malnutrition in early life has been linked to an increased likelihood to develop and an exacerbation of metabolic syndrome, however fish that were calorically restricted from five days after fertilization until three to nine months of age did not show signs of an exacerbated phenotype. In contrast, the groups that were shifted later in life from caloric restriction to the obesogenic environment did not completely catch up to the long-term obesity group by the end of our experiment. This dataset provides insight into a slowly exacerbating time-course of obesity phenotypes.
C1 [Leibold, Sandra; Lakshminarasimha, Amrutha Bagivalu; Hammerschmidt, Matthias; Michel, Maximilian] Univ Cologne, Inst Zool, Cologne, Germany.
   [Leibold, Sandra; Hammerschmidt, Matthias] Univ Cologne, Cologne Excellence Cluster Cellular Stress Respon, Cologne, Germany.
   [Gremse, Felix] Rhein Westfal TH Aachen, Fac Med, Inst Expt Mol Imaging, Dept Nanomed & Theranost, Aachen, Germany.
   [Gremse, Felix] Gremse IT GmbH, Aachen, Germany.
   [Hammerschmidt, Matthias] Univ Cologne, Ctr Mol Med Cologne, Cologne, Germany.
C3 University of Cologne; University of Cologne; RWTH Aachen University;
   University of Cologne
RP Michel, M (corresponding author), Univ Cologne, Inst Zool, Cologne, Germany.
EM maximichel@gmail.com
RI Michel, Maximilian/A-8079-2012
OI Michel, Maximilian/0000-0002-5910-5363; Bagivalu Lakshminarasimha,
   Amrutha/0000-0002-5742-4360
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NR 90
TC 4
Z9 4
U1 0
U2 11
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAY 11
PY 2022
VL 17
IS 5
AR e0267933
DI 10.1371/journal.pone.0267933
PG 24
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 2O1VP
UT WOS:000818854500040
PM 35544474
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Al Asoom, LI
AF Al Asoom, Lubna Ibrahim
TI The Association of Adiposity Indices and Plasma Vitamin D in Young
   Females in Saudi Arabia
SO INTERNATIONAL JOURNAL OF ENDOCRINOLOGY
LA English
DT Article
ID BODY-MASS INDEX; PARATHYROID-HORMONE; 25-HYDROXYVITAMIN D; METABOLIC
   SYNDROME; HYPOVITAMINOSIS-D; ADOLESCENTS; POPULATION; MARKERS; HEALTH
AB Background. Vitamin D deficiency is a global health problem. Some evidences indicate its association with metabolic syndrome, type II diabetes, and cardiovascular diseases. In the current study we aim to study the association of vitamin D level and indicators of adiposity in young Saudi females. Subjects and Methods. 87 young healthy Saudi females were recruited from University of Dammam, Dammam, Saudi Arabia. Each subject filled vitamin D questionnaire and had exercise stress test to determine VO2 peak. Body weight, BMI, waist and hip circumference, and ratios were determined. Blood was analyzed for 25-OH vitamin D, glucose, triglycerides, total cholesterol, and differential cholesterol. Results. 25-OH vitamin D/body weight was negatively associated with waist circumference and waist/stature ratio. No significant difference was found between the groups of BMI with regard to the data of questionnaire or 25-OH vitamin D/body weight. Obese and overweight subjects had lower VO2 peak. Conclusion. In young Saudi females we found that the relative value of vitamin D to body weight is a better indicator of vitamin D status particularly in obese subjects and it is negatively associated with adiposity measures of waist circumference and waist/stature ratio.
C1 [Al Asoom, Lubna Ibrahim] Univ Dammam UOD, Coll Med, Dept Physiol, POB 1982, Dammam 31441, Saudi Arabia.
C3 Imam Abdulrahman Bin Faisal University
RP Al Asoom, LI (corresponding author), Univ Dammam UOD, Coll Med, Dept Physiol, POB 1982, Dammam 31441, Saudi Arabia.
EM lasoom@uod.edu.sa
RI Asoom, Lubna/V-2977-2019; Al-Asoom, Lubna/A-3233-2015
OI Al-Asoom, Lubna/0000-0002-0371-2367
FU Deanship of Scientific Research at University of Dammam, Dammam, Saudi
   Arabia [2013183]
FX The author would like to thank her medical students: Dina Al Afandi,
   Leena Abu Ghararah, Deema Sallut, and Alanoud Althkair for their help in
   vitamin D questionnaire preparation. The project was executed by Grant
   no. 2013183 provided by the Deanship of Scientific Research at
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NR 30
TC 8
Z9 9
U1 0
U2 3
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1687-8337
EI 1687-8345
J9 INT J ENDOCRINOL
JI Int. J. Endocrinol.
PY 2016
VL 2016
AR 1215362
DI 10.1155/2016/1215362
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA DS9VC
UT WOS:000381130600001
PM 27525007
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Kelley, DS
   Adkins, YC
   Zunino, SJ
   Woodhouse, LR
   Bonnel, EL
   Breksa, AP
   Manners, GD
   Mackey, BE
AF Kelley, Darshan S.
   Adkins, Yuriko C.
   Zunino, Susan J.
   Woodhouse, Leslie R.
   Bonnel, Ellen L.
   Breksa, Andrew P., III
   Manners, Gary D.
   Mackey, Bruce E.
TI Citrus limonin glucoside supplementation decreased biomarkers of liver
   disease and inflammation in overweight human adults
SO JOURNAL OF FUNCTIONAL FOODS
LA English
DT Article
DE Liver enzymes; Metabolic syndrome; Nonalcoholic fatty liver disease;
   Cardiovascular disease; Obesity; Inflammation
ID GAMMA-GLUTAMYL-TRANSFERASE; HIGH-FAT DIET; SERUM ALANINE
   AMINOTRANSFERASE; INDUCED OBESE MICE; ORANGE JUICE;
   CARDIOVASCULAR-DISEASE; OXIDATIVE STRESS; DRUG-RESISTANCE;
   UNITED-STATES; CANCER-CELLS
AB Mixtures of limonoid glucosides demonstrated health benefits in human and animal studies; however, the specific metabolic effects of purified citrus limonin glucoside (LG) in humans are unknown. We determined effects of LG on circulating biomarkers of chronic inflammatory diseases such as nonalcoholic fatty liver disease (NAFLD), diabetes, CVD, and cancer in a cross-over, placebo controlled, double-blind study in overweight/obese individuals. LG had no specific adverse effects. It did not alter circulating concentrations of blood lipids, lipoproteins or their particle sizes, glucose, insulin, hematological parameters, and markers of inflammation except MMP-9 and TNF-alpha which were decreased by 38.7% and 10.7%, respectively. LG significantly decreased concentrations of liver proteins: gamma-glutamyl transferase (33.8%), alanine aminotransferase (13.1%), alkaline phosphatase (10.1%), and complement C3 (6.4%). Since liver enzymes are elevated in metabolic syndrome, NAFLD, diabetes, CVD, and chronic kidney disease and liver cancer, LG may be useful in the prevention and/or treatment of those diseases. Published by Elsevier Ltd.
C1 [Kelley, Darshan S.; Adkins, Yuriko C.; Zunino, Susan J.; Woodhouse, Leslie R.; Bonnel, Ellen L.] USDA ARS, Western Human Nutr Res Ctr, Davis, CA 95616 USA.
   [Kelley, Darshan S.; Adkins, Yuriko C.; Zunino, Susan J.; Woodhouse, Leslie R.; Bonnel, Ellen L.] Univ Calif Davis, Dept Nutr, Davis, CA 95616 USA.
   [Breksa, Andrew P., III; Manners, Gary D.; Mackey, Bruce E.] USDA, ARS, Western Reg Res Ctr, Albany, CA 94710 USA.
C3 United States Department of Agriculture (USDA); University of California
   System; University of California Davis; United States Department of
   Agriculture (USDA)
RP Kelley, DS (corresponding author), USDA ARS, Western Human Nutr Res Ctr, 430 West Hlth Sci Dr, Davis, CA 95616 USA.
EM darshan.kelley@ars.usda.gov
OI Breksa, Andrew/0000-0002-7472-7849; Adkins, Yuriko/0000-0002-5705-5964
FU U.S. Department of Agriculture, Agricultural Research Service
   [5306-51530-017-00D, 2030-41430-011-00D]; Coca-Cola Company, 1 Coca-Cola
   Plaza, Atlanta, USA
FX Supported in part by the U.S. Department of Agriculture, Agricultural
   Research Service (CRIS # 5306-51530-017-00D and CRIS #
   2030-41430-011-00D) and The Coca-Cola Company, 1 Coca-Cola Plaza,
   Atlanta, GA 30313 USA.
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NR 60
TC 27
Z9 28
U1 0
U2 32
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1756-4646
J9 J FUNCT FOODS
JI J. Funct. Food.
PD JAN
PY 2015
VL 12
BP 271
EP 281
DI 10.1016/j.jff.2014.11.026
PG 11
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA CB3CG
UT WOS:000349505200028
OA hybrid
DA 2025-06-11
ER

PT J
AU Renna, NF
   Diez, EA
   Miatello, RM
AF Renna, Nicolas F.
   Diez, Emiliano A.
   Miatello, Roberto M.
TI Effects of Dipeptidyl-Peptidase 4 Inhibitor about Vascular Inflammation
   in a Metabolic Syndrome Model
SO PLOS ONE
LA English
DT Article
ID GLUCAGON-LIKE PEPTIDE-1; ENDOTHELIAL FUNCTION; RELAXATION; RECEPTOR;
   GLUCOSE; MUSCLE; ARTERY; GLP-1; DPP-4
AB Background: In this study, we used vidagliptin(V) to examine the role of the DDP-IV, incretin system component, in the activation of different molecular inflammatory cytokines, NF-kB and VCAM-1 to generate a microenvironment that supports cardiovascular remodeling.
   Methods: Male WKY and SHR were separated into five groups: Control, FFR: WKY rats receiving a 10% (w/v) fructose solution during all 12 weeks, SHR, FFHR: SHR receiving a 10% (w/v) fructose solution during all 12 weeks and FFHR+V: (5 mg/kg per day for 6 weeks) (n = 8 each group). Metabolic variables and systolic blood pressure were measured. The TBRAS, eNOS activity, and NAD(P) H oxidase activity were estimated to evaluate oxidative stress. Cardiac and vascular remodeling were evaluated. To assess the cytokine, NF-kB and VCAM-1 immunostaining techniques were used.
   Results: The FFHR experimental model presents metabolic syndrome criteria, vascular and cardiac remodeling, vascular inflammation due to increased expression of NF-kB, VCAM-1, and pro-atherogenic cytokines. Chronic treatment with V was able to reverse total or partiality of variables studied.
   Conclusions: Data demonstrated an important effect of DDP-IV in reducing vascular inflammation, accompanied by a favorable reduction in metabolic and structural parameters.
C1 [Renna, Nicolas F.; Miatello, Roberto M.] Natl Univ Cuyo, Sch Med, Dept Pathol, Mendoza, Argentina.
   [Renna, Nicolas F.; Diez, Emiliano A.; Miatello, Roberto M.] Consejo Nacl Invest Cient & Tecn, Lab Cardiovasc Physiopathol, Inst Expt Med & Biol Cuyo IMBECU, Mendoza, Argentina.
C3 University Nacional Cuyo Mendoza; Consejo Nacional de Investigaciones
   Cientificas y Tecnicas (CONICET); Instituto de Medicina y BiologIa
   Experimental de Cuyo (IMBECU)
RP Renna, NF (corresponding author), Natl Univ Cuyo, Sch Med, Dept Pathol, Mendoza, Argentina.
EM nicolasrenna@fcm.uncu.edu.ar
RI Diez, Emiliano/KIB-2439-2024
OI Diez, Emiliano/0000-0001-5163-3703
FU Consejo Nacional de Investigaciones Cientificas y Tecnicas
FX This work was supported by Consejo Nacional de Investigaciones
   Cientificas y Tecnicas (http://www.conicet.gov.ar). The funders had no
   role in study design, data collection and analysis, decision to publish,
   or preparation of the manuscript.
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NR 29
TC 10
Z9 10
U1 0
U2 8
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD SEP 3
PY 2014
VL 9
IS 9
AR e106563
DI 10.1371/journal.pone.0106563
PG 8
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA AO3TB
UT WOS:000341257700088
PM 25184237
OA gold, Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Corona, G
   Maggi, M
AF Corona, Giovanni
   Maggi, Mario
TI The role of testosterone in erectile dysfunction
SO NATURE REVIEWS UROLOGY
LA English
DT Review
ID LATE-ONSET HYPOGONADISM; DISTINCT ANIMAL-MODELS; NITRIC-OXIDE SYNTHASE;
   SEXUAL DYSFUNCTION; METABOLIC SYNDROME; DOUBLE-BLIND; STRUCTURED
   INTERVIEW; ANDROGEN REPLACEMENT; REVERSIBLE REDUCTION; PDE5 INHIBITORS
AB Erectile dysfunction (ED) is a clinical disorder that results from a continuous spectrum of clinical factors, including physical illness (comprising the organic component of ED), reaction to stress (the intrapsychic component of ED) and relationship difficulties (the relationship component of ED). Testosterone clearly has a relevant role in all three causes of ED; the usefulness of this hormone in the treatment of ED has not, however, been completely clarified. The main physiological action of testosterone in the male sexual response is to regulate the timing of the erectile process as a function of sexual desire, thereby coordinating penile erection with sex. The link between ED, hypogonadism and underlying disorders (such as metabolic syndrome and type 2 diabetes mellitus) is nowadays well documented. The recognition of underlying disorders might be useful in motivating men with ED to improve their health-related lifestyle choices. Hence, patients with ED might be considered 'lucky', because their disorder offers the opportunity to undergo medical examinations to detect underlying disease. Both ED and hypogonadism are treatable conditions. A range of testosterone preparations are available for supplementation; their combination with phosphodiesterase 5 inhibitors might improve outcomes in some cases.
C1 [Corona, Giovanni; Maggi, Mario] Univ Florence, Sexual Med & Androl Unit, Dept Clin Physiopathol, I-50139 Florence, Italy.
C3 University of Florence
RP Maggi, M (corresponding author), Univ Florence, Sexual Med & Androl Unit, Dept Clin Physiopathol, Viale Pieraccini 6, I-50139 Florence, Italy.
EM m.maggi@dfc.unifi.it
RI Maggi, Mario/AAB-8284-2019
OI MAGGI, Mario/0000-0003-3267-4221
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NR 103
TC 121
Z9 138
U1 0
U2 21
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 1759-4812
EI 1759-4820
J9 NAT REV UROL
JI Nat. Rev. Urol.
PD JAN
PY 2010
VL 7
IS 1
BP 46
EP 56
DI 10.1038/nrurol.2009.235
PG 11
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 542AD
UT WOS:000273462600007
PM 19997070
DA 2025-06-11
ER

PT J
AU González-Domínguez, A
   Domínguez-Riscart, J
   Savolainen, O
   Lechuga-Sancho, A
   Landberg, R
   González-Domínguez, R
AF Gonzalez-Dominguez, Alvaro
   Dominguez-Riscart, Jesus
   Savolainen, Otto
   Lechuga-Sancho, Alfonso
   Landberg, Rikard
   Gonzalez-Dominguez, Raul
TI Identifying metabotypes of insulin resistance severity in children with
   metabolic syndrome
SO CARDIOVASCULAR DIABETOLOGY
LA English
DT Article
DE Insulin resistance; Childhood obesity; Metabolomics; Metabolic
   flexibility
ID OBESITY
AB BackgroundInsulin resistance is a frequent precursor of typical obesity and metabolic syndrome complications. However, accurate diagnosis remains elusive because of its pathophysiological complexity and heterogeneity. Herein, we have explored the utility of insulin secretion dynamics in response to an oral glucose tolerance test as a surrogate marker to identify distinct metabotypes of disease severity.MethodsThe study population consisted of children with obesity and insulin resistance, stratified according to the post-challenge insulin peak timing (i.e., early, middle, and late peak), from whom fasting and postprandial plasma and erythrocytes were collected for metabolomics analysis.ResultsChildren with late insulin peak manifested worse cardiometabolic health (i.e., higher blood pressure, glycemia, and HOMA-IR scores) than early responders. These subjects also showed more pronounced changes in metabolites mirroring failures in energy homeostasis, oxidative stress, metabolism of cholesterol and phospholipids, and adherence to unhealthy dietary habits. Furthermore, delayed insulin peak was associated with impaired metabolic flexibility, as reflected in compromised capacity to regulate mitochondrial energy pathways and the antioxidant defense in response to glucose overload.ConclusionsAltogether, these findings suggest that insulin resistance could encompass several phenotypic subtypes characterized by graded disturbances in distinctive metabolic derangements occurring in childhood obesity, which serve as severity predictive markers.
C1 [Gonzalez-Dominguez, Alvaro; Dominguez-Riscart, Jesus; Lechuga-Sancho, Alfonso; Gonzalez-Dominguez, Raul] Univ Cadiz, Hosp Univ Puerta Mar, Inst Invest Innovac Biomed Cadiz INiBICA, Cadiz 11009, Spain.
   [Gonzalez-Dominguez, Alvaro] Icahn Sch Med Mt Sinai, Div Liver Dis, New York, NY 10029 USA.
   [Dominguez-Riscart, Jesus; Lechuga-Sancho, Alfonso] Hosp Univ Puerta Mar, Serv Pediat, Unidad Endocrinol Pediat & Diabet, Cadiz 11009, Spain.
   [Savolainen, Otto; Landberg, Rikard] Chalmers Univ Technol, Dept Life Sci, Div Food & Nutr Sci, SE-41296 Gothenburg, Sweden.
   [Lechuga-Sancho, Alfonso] Univ Cadiz, Fac Med, Dept Materno Infantil & Radiol, Cadiz 11009, Spain.
C3 Universidad de Cadiz; Hospital Universitario Puerta del Mar; Icahn
   School of Medicine at Mount Sinai; Universidad de Cadiz; Hospital
   Universitario Puerta del Mar; Chalmers University of Technology;
   Universidad de Cadiz
RP González-Domínguez, R (corresponding author), Univ Cadiz, Hosp Univ Puerta Mar, Inst Invest Innovac Biomed Cadiz INiBICA, Cadiz 11009, Spain.
RI González-Domínguez, Raúl/E-5125-2016; González Domínguez,
   Álvaro/HJH-1098-2023; Lechuga-Sancho, Alfonso/M-2712-2015
OI Lechuga-Sancho, Alfonso/0000-0001-5861-6041
FU Universidad de Cadiz
FX Not applicable.
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NR 41
TC 1
Z9 1
U1 0
U2 1
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1475-2840
J9 CARDIOVASC DIABETOL
JI Cardiovasc. Diabetol.
PD AUG 27
PY 2024
VL 23
IS 1
AR 315
DI 10.1186/s12933-024-02412-x
PG 9
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism
GA E0K7Q
UT WOS:001299987700002
PM 39192263
OA gold
DA 2025-06-11
ER

PT J
AU Darvishi, M
   Alsaraf, KM
   Toama, MA
   Hadrawi, SK
   Ramadan, MF
   Pirhadi, M
   Adeli, OA
AF Darvishi, Mohammad
   Alsaraf, Khulood Majid
   Toama, Mariam Alaa
   Hadrawi, Salema K.
   Ramadan, Montather F.
   Pirhadi, Mohadeseh
   Adeli, Omid-Ali
TI A Review of the Effects of Omega-3 and Omega-6 on Alcoholic and
   Non-Alcoholic Fatty Liver
SO ADVANCEMENTS IN LIFE SCIENCES
LA English
DT Review
DE Omega-3; Omega-6; NAFLD; EPA; DHA
ID CARDIOVASCULAR-DISEASE; BARIATRIC SURGERY; OMEGA-3-FATTY-ACIDS; ACID;
   STEATOHEPATITIS; SUPPLEMENTATION; INVOLVEMENT; CHILDREN; EXERCISE; CELLS
AB Non-alcoholic fatty liver disease is a type of fatty fat that causes an increase in alcohol consumption. Excessive alcohol consumption causes inflammation, and liver damage. The certain fatty acids (FAs) may be involved in this liver damage. Anti-inflammatory and blood lipid lowering effects are the effects of omega-3 unsaturated fatty acids (n-3 PUFAs). NAFLD is the hepatic manifestation of metabolic syndrome because obesity and insulin resistance are the main pathogenic factors of both diseases. NAFLD is a disease associated with metabolic syndrome. Most patients with NAFLD are obese, although the disease can also affect non-obese people. Metabolic and genetic factors play an important role in the occurrence of this disease. Oxidative stress, lipotoxicity and inflammation play a key role in the development of NAFLD. There is a lot of evidence for the therapeutic potential of omega-3 PUFAs fatty acids (n-3 PUFA), mainly docosahexaenoic acid and eicosatetraenoic acid in the treatment of metabolic diseases due to their antioxidant and anti-inflammatory properties. Therefore, in this review article, we examined the effects of omega-3 and omega-6 on alcoholic and non-alcoholic fatty liver disease.
C1 [Darvishi, Mohammad] AJA Univ Med Sci, Infect Dis & Trop Med Res Ctr IDTMRC, Dept Aerosp & Subaquat Med, Tehran, Iran.
   [Toama, Mariam Alaa] Natl Univ Sci & Technol, Coll Pharm, Dhi Qar, Iraq.
   [Hadrawi, Salema K.] Islamic Univ, Coll Tech Engn, Refrigerat & Air Conditioning Tech Engn Dept, Najaf, Iraq.
   [Ramadan, Montather F.] Al Ayen Univ, Coll Dent, Thi Qar, Iraq.
   [Pirhadi, Mohadeseh] Univ Tehran Med Sci, Sch Publ Hlth, Dept Environm Hlth, Food Safety Div, Tehran, Iran.
   [Adeli, Omid-Ali] Lorestan Univ Med Sci, Sch Med, Dept Pathol, Khorramabad, Iran.
   [Adeli, Omid-Ali] Lorestan Univ Med Sci, Razi Herbal Med Res Ctr, Khorramabad, Iran.
C3 National University of Science & Technology - Iraq; Islamic University
   College; Al-Ayen University; Tehran University of Medical Sciences;
   Lorestan University of Medical Sciences; Lorestan University of Medical
   Sciences
RP Adeli, OA (corresponding author), Lorestan Univ Med Sci, Sch Med, Dept Pathol, Khorramabad, Iran.; Adeli, OA (corresponding author), Lorestan Univ Med Sci, Razi Herbal Med Res Ctr, Khorramabad, Iran.
EM omidalieadeli@yahoo.com
FU Shahid Beheshti University of Medical Sciences, Tehran, Iran
FX The authors thankful from Shahid Beheshti University of Medical
   Sciences, Tehran, Iran for the support. The co-corresponding author of
   the article is Dr. Nasrullah Naghdi.
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NR 73
TC 1
Z9 1
U1 2
U2 3
PU The Running Line
PI Lahore
PA 79-A Block, Punjab University Town 1, Abdul Sattar Edhi road, Niaz Baig,
   Lahore, PAKISTAN
SN 2310-5380
J9 ADV LIFE SCI-PAK
JI Advan. Life Sci.
PD DEC
PY 2023
VL 10
IS 4
BP 530
EP 536
PG 7
WC Biology
WE Emerging Sources Citation Index (ESCI)
SC Life Sciences & Biomedicine - Other Topics
GA FI9I3
UT WOS:001145245500017
DA 2025-06-11
ER

PT J
AU Benotti, P
   Wood, GC
   Argyropoulos, G
   Pack, A
   Keenan, BT
   Gao, X
   Gerhard, G
   Still, C
AF Benotti, Peter
   Wood, G. Craig
   Argyropoulos, George
   Pack, Allan
   Keenan, Brendan T.
   Gao, Xiang
   Gerhard, Glenn
   Still, Christopher
TI The impact of obstructive sleep apnea on nonalcoholic fatty liver
   disease in patients with severe obesity
SO OBESITY
LA English
DT Article
ID CHRONIC INTERMITTENT HYPOXIA; INSULIN-RESISTANCE; SURGICAL-PATIENTS;
   STEATOHEPATITIS; OXYGEN; PREVALENCE; DIAGNOSIS; HISTOLOGY; STRESS;
   ADULTS
AB ObjectiveObstructive sleep apnea (OSA) is common among candidates for bariatric surgery. OSA and its associated intermittent hypoxia have been implicated in the pathogenesis of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis. A large cohort of bariatric surgery patients was studied in an effort to explore the relationship between OSA severity, hypoxia, metabolic syndrome, and the severity of NAFLD.
   MethodsBariatric surgery candidates who underwent both polysomnography and liver biopsy were studied. The severity of OSA as determined by the apnea-hypopnea index (AHI) and parameters of hypoxia was studied in relation to extent of abnormalities of liver histology as measured by the presence of hepatic steatosis, inflammation, and fibrosis.
   ResultsThe study cohort included 362 patients with a mean age of 46.2 years and BMI of 49.9 kg/m(2). On the basis of AHI, 26% of the cohort had no OSA, 32% mild OSA, 22% moderate OSA, and 20% severe OSA. For the study subjects without metabolic syndrome, positive correlations were found between OSA severity, as measured by AHI, and parameters of hypoxia, with the severity of NAFLD.
   ConclusionsOSA severity and its accompanying hypoxia are associated with the severity of NAFLD.
C1 [Benotti, Peter; Wood, G. Craig; Argyropoulos, George; Still, Christopher] Geisinger Obes Inst, Danville, PA USA.
   [Pack, Allan; Keenan, Brendan T.] Univ Penn, Philadelphia, PA 19104 USA.
   [Gao, Xiang] Penn State Univ, University Pk, PA 16802 USA.
   [Gerhard, Glenn] Temple Univ, Philadelphia, PA 19122 USA.
C3 University of Pennsylvania; Pennsylvania Commonwealth System of Higher
   Education (PCSHE); Pennsylvania State University; Pennsylvania State
   University - University Park; Penn State Behrend; Pennsylvania
   Commonwealth System of Higher Education (PCSHE); Temple University
RP Benotti, P (corresponding author), Geisinger Obes Inst, Danville, PA USA.
EM pbenotti64@gmail.com
RI Keenan, Brendan/HPH-2801-2023; Gao, Xiang/KFQ-2812-2024
OI Gao, Xiang/0000-0003-2617-6509; Keenan, Brendan/0000-0002-9070-847X;
   Pack, Allan/0000-0002-2879-0484
FU Mid-Atlantic Nutrition Obesity Research Center [DK072488]
FX This research was supported by grant DK072488 from the Mid-Atlantic
   Nutrition Obesity Research Center.
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NR 32
TC 33
Z9 34
U1 0
U2 13
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1930-7381
EI 1930-739X
J9 OBESITY
JI Obesity
PD APR
PY 2016
VL 24
IS 4
BP 871
EP 877
DI 10.1002/oby.21409
PG 7
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA DI6MM
UT WOS:000373613200018
PM 26880657
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Tsuneyama, K
   Baba, H
   Kikuchi, K
   Nishida, T
   Nomoto, K
   Hayashi, S
   Miwa, S
   Nakajima, T
   Nakanishi, Y
   Masuda, S
   Terada, M
   Imura, J
   Selmi, C
AF Tsuneyama, Koichi
   Baba, Hayato
   Kikuchi, Kentaro
   Nishida, Takeshi
   Nomoto, Kazuhiro
   Hayashi, Shinichi
   Miwa, Shigeharu
   Nakajima, Takahiko
   Nakanishi, Yuko
   Masuda, Shinji
   Terada, Mitsuhiro
   Imura, Johji
   Selmi, Carlo
TI Autoimmune Features in Metabolic Liver Disease: A Single-Center
   Experience and Review of the Literature
SO CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY
LA English
DT Review
DE Metabolic syndrome; Female sex; Non-alcoholic fatty liver disease
ID PRIMARY BILIARY-CIRRHOSIS; NONALCOHOLIC STEATOHEPATITIS;
   SEX-DIFFERENCES; OXIDATIVE STRESS; T-CELLS; MICE; GENDER; CHOLANGITIS;
   ANTIBODIES; MODEL
AB Non-alcoholic steatohepatitis (NASH) is the progressive phenotype of non-alcoholic fatty liver disease associated with the metabolic syndrome. The existence of autoimmune features in NASH has been reported, but its significance remains unclear. We herein report the autoantibody profile of 54 patients with histologically proven NASH and further determined the development of autoimmunity in three different murine NASH models (monosodium glutamate, CDAA (choline-deficient l-amino acid-defined), and TSOD (Tsumura Suzuki, Obese Diabetes)) at 48 weeks of age. Forty-eight percent (26/54) of NASH cases were positive for antinuclear (ANA) or antimitochondrial antibody and manifested histological signs of overlap with autoimmune hepatitis and primary biliary cirrhosis, respectively. These patients were significantly older (60 +/- 10 versus 50 +/- 16 years), more frequently women (81 % versus 43 %), and with more severe portal inflammatory infiltrate compared with patients without autoimmunity. In one third of mice, regardless of the model, we observed a marked lymphoid infiltrate with non-suppurative cholangitis, and several cases were ANA-positive, but none AMA-positive. Our data suggest that autoimmunity may share some pathogenetic traits with the chronic inflammation of NASH, possibly related to advanced age.
C1 [Tsuneyama, Koichi; Baba, Hayato; Nishida, Takeshi; Nomoto, Kazuhiro; Hayashi, Shinichi; Miwa, Shigeharu; Nakajima, Takahiko; Nakanishi, Yuko; Imura, Johji] Toyama Univ, Dept Diagnost Pathol, Grad Sch Med & Pharmaceut Sci, Toyama 9300194, Japan.
   [Kikuchi, Kentaro] Teikyo Univ, Mizonokuchi Hosp, Dept Internal Med 4, Kanagawa, Japan.
   [Masuda, Shinji] Kouseiren Takaoka Hosp, Dept Pathol, Takaoka, Toyama, Japan.
   [Terada, Mitsuhiro] Kouseiren Takaoka Hosp, Dept Internal Med, Takaoka, Toyama, Japan.
   [Selmi, Carlo] Humanitas Clin & Res Ctr, Div Rheumatol & Clin Immunol, Milan, Italy.
   [Selmi, Carlo] Univ Calif Davis, Div Rheumatol Allergy & Clin Immunol, Davis, CA 95616 USA.
C3 University of Toyama; Teikyo University; University of California
   System; University of California Davis
RP Tsuneyama, K (corresponding author), Toyama Univ, Dept Diagnost Pathol, Grad Sch Med & Pharmaceut Sci, Toyama 9300194, Japan.
EM ktsune@med.u-toyama.ac.jp
RI Selmi, Carlo/ABG-4899-2021
OI Tsuneyama, Koichi/0000-0002-0670-9868; Selmi, Carlo/0000-0002-0323-0376
FU JSPS KAKENHI [0293341, 10293341]; Takeda Science Foundation;
   Grants-in-Aid for Scientific Research [24390181] Funding Source: KAKEN
FX The authors are thankful to Mr. Tokimasa Kumada and Mr. Hideki Hatta for
   their help and technical assistance with experiments and to Ms. Yukari
   Inoue for the excellent support in the manuscript preparation. This work
   was supported by JSPS KAKENHI Grant Numbers 0293341 and 10293341 and a
   Research grant of 2010 Takeda Science Foundation.
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NR 63
TC 36
Z9 38
U1 0
U2 9
PU HUMANA PRESS INC
PI TOTOWA
PA 999 RIVERVIEW DRIVE SUITE 208, TOTOWA, NJ 07512 USA
SN 1080-0549
EI 1559-0267
J9 CLIN REV ALLERG IMMU
JI Clin. Rev. Allergy Immunol.
PD AUG
PY 2013
VL 45
IS 1
BP 143
EP 148
DI 10.1007/s12016-013-8383-x
PG 6
WC Allergy; Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Allergy; Immunology
GA 185GR
UT WOS:000321955700012
PM 23842720
DA 2025-06-11
ER

PT J
AU Duclos, M
   Pereira, PM
   Barat, P
   Gatta, B
   Roger, P
AF Duclos, M
   Pereira, PM
   Barat, P
   Gatta, B
   Roger, P
TI Increased cortisol bioavailability, abdominal obesity, and the metabolic
   syndrome in obese women
SO OBESITY RESEARCH
LA English
DT Article
DE 11 beta HSD; corticosteroid binding protein; metabolic syndrome;
   glucocorticoid sensitivity
ID PITUITARY-ADRENAL AXIS; BODY-FAT DISTRIBUTION; PERFORMANCE
   LIQUID-CHROMATOGRAPHY; CORTICOSTEROID-BINDING GLOBULIN; CENTRAL
   ADIPOSITY; SENSITIVITY; STRESS; MEN; GLUCOCORTICOIDS; DEXAMETHASONE
AB Objective: This study was conducted to obtain a detailed profile of hypothalamo-pituitary-adrenal (HPA) axis activity and reactivity and its differential relationships with body fat distribution and total fat mass in premenopausal obese women.
   Research Methods and Procedures: Cortisol responses to stimulation (awakening, food intake, exercise) and suppression (0.25 mg dexamethasone), cortisol metabolism, and tissue sensitivity to glucocorticoids were studied in 53 premenopausal obese women grouped according to their waist-to hip ratio: women with abdominal body fat distribution (A-BFD; n = 31) and women with peripheral fat distribution (P-BFD; n = 22).
   Results: Comparatively, A-BFD) women had 1) lower awakening salivary cortisol levels; 2) increased salivary responsiveness to a standardized lunch; 3) similar pituitary sensitivity to dexamethasone but decreased sensitivity of monocytes to dexamethasone; 4) similar 24-hour urinary free cortisol but increased 24-hour urinary ratio of cortisone-to-cortisol; and 5) no difference in corticosteroid binding protein parameters.
   Discussion: Although abdominal obesity is not very different from generalized obesity in terms of HPA function, subtle variations in HPA axis activity and reactivity are evidenced in A-BFD premenopausal obese women.
C1 Univ Bordeaux 2, Inst Francois Magendie, INSERM, U471,Lab Neurogenet & Stress, F-33077 Bordeaux, France.
   CHU Bordeaux, Serv Endocrinol Pediat, Hop Enfants, Bordeaux, France.
   CHU Bordeaux, Hop Haut Leveque, Serv Endocrinol, Pessac, France.
C3 Universite de Bordeaux; Institut National de la Sante et de la Recherche
   Medicale (Inserm); Universite de Bordeaux; CHU Bordeaux; CHU Bordeaux;
   Universite de Bordeaux
RP Duclos, M (corresponding author), Univ Bordeaux 2, Inst Francois Magendie, INSERM, U471,Lab Neurogenet & Stress, Rue C Saint Saens, F-33077 Bordeaux, France.
EM duclos@pop.bordeaux.inserm.fr
RI Barat, Pascal/E-4013-2017; Duclos, Martine/AAI-5684-2020
OI Cherifi, Blandine/0000-0002-7399-1330; BARAT, Pascal/0000-0001-5029-0200
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NR 40
TC 116
Z9 126
U1 0
U2 9
PU NORTH AMER ASSOC STUDY OBESITY
PI SILVER SPRING
PA 8630 FENTON ST, SUITE 918, SILVER SPRING, MD 20910 USA
SN 1071-7323
J9 OBES RES
JI Obes. Res.
PD JUL
PY 2005
VL 13
IS 7
BP 1157
EP 1166
DI 10.1038/oby.2005.137
PG 10
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 955GE
UT WOS:000231212800006
PM 16076984
OA Bronze
DA 2025-06-11
ER

PT J
AU Shin, SK
   Kwon, EY
AF Shin, Su-Kyung
   Kwon, Eun-Young
TI Kaempferol ameliorates metabolic syndrome by inhibiting inflammation and
   oxidative stress in high-fat diet-induced obese mice
SO NUTRITION RESEARCH AND PRACTICE
LA English
DT Article
DE Obesity; inflammation; oxidative stress; fatty liver; metabolic syndrome
ID INSULIN-RESISTANCE; ADIPOSE-TISSUE; LIVER; DYSFUNCTION; QUERCETIN;
   ASSAY; RISK; ACID
AB BACKGROUND/OBJECTIVES: Kaempferol (Ka) is one of the most widely occurring flavonoids found in large amounts in various plants. Ka has anti-obesity, antioxidant, and antiinflammatory effects. Despite the numerous papers documenting the efficacy of Ka, some controversy remains. Therefore, this study examined the impact of Ka using 3T3 -L1 and highfat diet-induced obese mice. MATERIALS/METHODS: 3T3 -L1 cells were treated with 50 mu M Ka from the initiation of 3T3 -L1 differentiation at D0 until the completion of differentiation on D8. Thirty male mice (C57BL/6J, 4 weeks old) were divided into 3 groups: normal diet (ND), high -fat diet (HFD), and HFD + 0.02% (w/w) Ka (Ka) group. All mice were fed their respective diets ad libitum for 16 weeks. The mice were sacrificed, and the plasma and hepatic lipid levels, white adipose tissue weight, hepatic glucose level, lipid level, and antioxidant enzyme activities were analyzed, and immunohistochemistry staining was performed. RESULTS: Ka suppressed the hypertrophy of 3T3 -L1 cells, and the Ka-supplemented mice showed a significant decrease in perirenal, retroperitoneal, mesenteric, and subcutaneous fat compared to the HFD group. Ka supplementation in high -fat diet-induced obese mice also improved the overall blood lipid concentration (total cholesterol, non-high-density lipoprotein-cholesterol, phospholipids, and apolipoprotein B). Ka supplementation in highfat-induced obesity mice reduced hepatic steatosis and insulin resistance by modulating the hepatic lipid (glucose-6-phosphate dehydrogenase, fatty acid synthase, malic enzyme, phosphatidate phosphohydrolase, and beta -oxidation) activities and glucose (glucokinase, phosphoenolpyruvate carboxykinase, and G6pase)-regulating enzymes. Ka supplementation ameliorated the erythrocyte and hepatic mitochondrial H 2 O 2 and inflammation levels (plasma tumor necrosis factor-alpha, monocyte chemoattractant protein -1, interleukin-6, and interferon -gamma and fibrosis of liver and epididymal fat). CONCLUSION: Ka may be beneficial for preventing diet-induced obesity, inflammation, oxidative stress, and diabetes.
C1 [Shin, Su-Kyung; Kwon, Eun-Young] Kyungpook Natl Univ, Dept Food Sci & Nutr, 80 Daehak Ro, Daegu 41566, South Korea.
   [Shin, Su-Kyung; Kwon, Eun-Young] Kyungpook Natl Univ, Ctr Food & Nutr Genom Res, Daegu 41566, South Korea.
   [Kwon, Eun-Young] Kyungpook Natl Univ, Ctr Beautiful Aging, Daegu 41566, South Korea.
C3 Kyungpook National University (KNU); Kyungpook National University
   (KNU); Kyungpook National University (KNU)
RP Kwon, EY (corresponding author), Kyungpook Natl Univ, Dept Food Sci & Nutr, 80 Daehak Ro, Daegu 41566, South Korea.
EM eykwon@knu.ac.kr
OI Shin, Su-Kyung/0000-0002-8918-3995
FU National Research Foundation of Korea (NRF) - Korea government (MSIT)
   [RS-2023-00237118, 2021R1A2C1011233]
FX Funding This work was supported by the National Research Foundation of
   Korea (NRF) grant funded by the Korea government (MSIT) (No.
   RS-2023-00237118 and No. 2021R1A2C1011233) .
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NR 51
TC 2
Z9 2
U1 3
U2 5
PU KOREAN NUTRITION SOC
PI SEOUL
PA 804 KST CTR, 635-4 YEOGSAM-SONG KANGNAM-KU, SEOUL, 135-703, SOUTH KOREA
SN 1976-1457
EI 2005-6168
J9 NUTR RES PRACT
JI Nutr. Res. Pract.
PD JUN
PY 2024
VL 18
IS 3
BP 325
EP 344
DI 10.4162/nrp.2024.18.3.325
PG 20
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA TR4J7
UT WOS:001242971000002
PM 38854471
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Solomon, Z
   Levin, Y
   Ben Assayag, E
   Furman, O
   Shenhar-Tsarfaty, S
   Berliner, S
   Ohry, A
AF Solomon, Zahava
   Levin, Yafit
   Ben Assayag, Einor
   Furman, Orit
   Shenhar-Tsarfaty, Shani
   Berliner, Shlomo
   Ohry, Avi
TI The Implication of Combat Stress and PTSD Trajectories in Metabolic
   Syndrome and Elevated C-Reactive Protein Levels: A Longitudinal Study
SO JOURNAL OF CLINICAL PSYCHIATRY
LA English
DT Article
ID WORLD-WAR-II; CORONARY-HEART-DISEASE; CARDIOVASCULAR-DISEASE;
   PSYCHIATRIC-DISORDERS; INFLAMMATORY MARKERS; INCIDENT CORONARY; FORMER
   PRISONERS; RISK-FACTORS; MORTALITY; VETERANS
AB Objective: This study sheds light on the importance of long-term follow-up of trauma survivors, posttraumatic stress disorder (PTSD) trajectories, and early detection of health risk factors in trauma survivors. The present study prospectively assessed the following over 23 years: (1) the association of psychological and physiologic stress during captivity with elevated C-reactive protein (CRP) levels and metabolic syndrome (MetS), which includes hypertension; elevated levels of insulin, triglycerides, and fasting glucose; decreased levels of high-density lipoprotein cholesterol; and obesity and (2) the implication of PTSD trajectories in elevated CRP levels and MetS.
   Methods: Measurements were taken in 1991, 2003, 2008, and 2015. Participants were 116 Israeli combat veterans of the 1973 Yom Kippur War (of these, 101 were former prisoners of war [ex-POWs] and 15 were comparable controls). The medical assessments relevant for this study were body mass index, fasting blood glucose levels, and diabetes, blood pressure or a diagnosis of hypertension, high-density lipoprotein cholesterol and triglyceride levels, and medication intake. In addition, the PTSD Inventory was used to assess PTSD symptoms and trajectories over time according to DSM-IV-TR PTSD criteria.
   Results: Captivity-in particular, the captivity stressors of weight loss, physical suffering, psychological suffering, and humiliation-was implicated in both elevated CRP levels and MetS, significantly so with elevated CRP levels (P=.01, R-2 = 0.33). Captivity-induced PTSD, in particular chronic and delayed PTSD trajectories, was associated with elevated CRP levels and MetS, significantly so for MetS (P=.05).
   Conclusions: Monitoring inflammation using markers like CRP level in trauma survivors can be beneficial, particularly if PTSD is chronic or delayed. Clinicians treating trauma survivors should raise awareness of the importance of such measures in light of long-term health vulnerabilities. (C) Copyright 2017 Physicians Postgraduate Press, Inc.
C1 [Solomon, Zahava; Levin, Yafit] Tel Aviv Univ, Bob Shapell Sch Social Work, Tel Aviv, Israel.
   [Solomon, Zahava] I Core Res Ctr Mass Trauma, Tel Aviv, Israel.
   [Ben Assayag, Einor; Shenhar-Tsarfaty, Shani; Berliner, Shlomo] Tel Aviv Sourasky Med Ctr, Dept Internal Med, Tel Aviv, Israel.
   [Furman, Orit] Weizmann Inst Sci, Dept Neurobiol, Rehovot, Israel.
   [Furman, Orit] Max Planck Inst Psychiat, Dept Stress Neurobiol & Neurogenet, Munich, Germany.
   [Berliner, Shlomo; Ohry, Avi] Tel Aviv Univ, Sackler Fac Med, Tel Aviv, Israel.
C3 Tel Aviv University; Tel Aviv University; Sackler Faculty of Medicine;
   Tel Aviv Sourasky Medical Center; Weizmann Institute of Science; Max
   Planck Society; Tel Aviv University; Sackler Faculty of Medicine
RP Solomon, Z (corresponding author), Tel Aviv Univ, I Core Res Ctr Mass Trauma, Bob Shapell Sch Social Work, POB 39040, IL-69978 Tel Aviv, Israel.
EM solomon@post.tau.ac.il
RI Levin, Yafit/MHR-0455-2025
OI Furman, Orit/0000-0001-6823-9542; Shenhar-Tsarfaty,
   Shani/0000-0002-8268-1799
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NR 76
TC 23
Z9 24
U1 0
U2 12
PU PHYSICIANS POSTGRADUATE PRESS
PI MEMPHIS
PA P O BOX 752870, MEMPHIS, TN 38175-2870 USA
SN 0160-6689
EI 1555-2101
J9 J CLIN PSYCHIAT
JI J. Clin. Psychiatry
PD NOV-DEC
PY 2017
VL 78
IS 9
BP E1180
EP E1186
DI 10.4088/JCP.16m11344
PG 7
WC Psychology, Clinical; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA FR0YZ
UT WOS:000418792500004
PM 28994516
DA 2025-06-11
ER

PT J
AU Kagota, S
   Maruyama, K
   Tada, Y
   Fukushima, K
   Umetani, K
   Wakuda, H
   Shinozuka, K
AF Kagota, Satomi
   Maruyama, Kana
   Tada, Yukari
   Fukushima, Kazuhito
   Umetani, Keiji
   Wakuda, Hirokazu
   Shinozuka, Kazumasa
TI Chronic oxidative-nitrosative stress impairs coronary vasodilation in
   metabolic syndrome model rats
SO MICROVASCULAR RESEARCH
LA English
DT Article
ID SOLUBLE GUANYLATE-CYCLASE; NITRIC-OXIDE SYNTHASE; ENDOTHELIAL
   DYSFUNCTION; HYPERTENSIVE-RATS; VASCULAR DYSFUNCTION;
   INSULIN-RESISTANCE; ANGIOTENSIN-II; MIMETIC TEMPOL; ANIMAL-MODEL; HEME
   MOIETY
AB Metabolic syndrome (MetS) is a combination of clinical disorders that together increase the risk for cardiovascular disease and diabetes. SHRSP.Z-Lepr(fa)/IzmDmcr (SHRSP.ZF) rats with MetS show impaired nitric oxide-mediated relaxation in coronary and mesenteric arteries, and angiotensin II receptor type 1 blockers protect against dysfunction and oxidative-nitrosative stress independently of metabolic effects. We hypothesize that superoxide contributes to functional deterioration in SHRSP.ZF rats. To test our hypothesis, we studied effects of treatment with tempol, a membrane-permeable radical scavenger, on impaired vasodilation in SHRSP.ZF rats. Tempol did not alter body weight, high blood pressure, or metabolic abnormalities, but prevented impairment of acetylcholine-induced and nitroprusside-induced vasodilation in the coronary and mesenteric arteries. Furthermore, tempol reduced the levels of serum thiobarbituric acid reactive substance (TEARS) and 3-nitrotyrosine content in mesenteric arteries. Systemic administration of tempol elevated the expression of soluble guanylate cyclase (sGC) above basal levels in mesenteric arteries of SHRSP.ZF rats. However, acute treatment with tempol or ebselen, a peroxynitrite scavenger, did not ameliorate impaired relaxation of isolated mesenteric arteries. No nitration of tyrosine residues in sGC was observed; however, sGC mRNA expression levels in the arteries of SHRSP.ZF rats were lower than those in the arteries of Wistar-Kyoto rats. Levels of Thr(496)- and Ser(1177)-phosphofylated endothelial nitric oxide synthase (eNOS) were lower in arteries of SHRSP.ZF rats, and acetylcholine decreased Thr(496)-phosphorylated eNOS levels. These results indicated that prolonged superoxide production, leading to oxidative-nitrosative stress, was associated with impaired vasodilation in SHRSP.ZF rats with MetS. Down-regulated sGC expression may be linked to dysfunction, while reduced NO bioavailability/eNOS activity and modified sGC activity due to superoxide production were excluded as pivotal mechanisms. (C) 2013 Elsevier Inc. All rights reserved.
C1 [Kagota, Satomi; Maruyama, Kana; Tada, Yukari; Wakuda, Hirokazu; Shinozuka, Kazumasa] Mukogawa Womens Univ, Fac Pharmaceut Sci, Dept Pharmacol, Nishinomiya, Hyogo 663, Japan.
   [Fukushima, Kazuhito] Natl Cerebral & Cardiovasc Ctr, Dept Radiol, Osaka, Japan.
   [Umetani, Keiji] SPring 8, Japan Synchrotron Radiat Res Inst, Sayo, Japan.
C3 Mukogawa Women's University; National Cerebral & Cardiovascular Center -
   Japan; Japan Synchrotron Radiation Research Institute
RP Kagota, S (corresponding author), 11-68 Koshien Kyuban Cho, Nishinomiya, Hyogo 6638179, Japan.
EM skagota@mukogawa-u.ac.jp
RI Wakuda, Hirokazu/KZU-6319-2024
OI Wakuda, Hirokazu/0000-0002-5717-8251
FU Ministry of Education, Sciences, Sports, and Culture of Japan
   [23590315]; Grants-in-Aid for Scientific Research [23590315] Funding
   Source: KAKEN
FX We thank Ms. Yasuko Mino, Ms. Yumie Shinoda and Ms. Naoko Nose for their
   technical assistance. This research was partly supported by a Grant-in
   Aid for Scientific Research from the Ministry of Education, Sciences,
   Sports, and Culture of Japan (23590315). Synchrotron radiation
   experiments were performed at the BL28B2 in SPring-8 (Sayo, Japan) with
   the approval of the Japan Synchrotron Radiation Research Institute
   (2008A1512 and 2008B1050).
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NR 41
TC 13
Z9 15
U1 0
U2 4
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0026-2862
EI 1095-9319
J9 MICROVASC RES
JI Microvasc. Res.
PD JUL
PY 2013
VL 88
BP 70
EP 78
DI 10.1016/j.mvr.2013.04.001
PG 9
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 239FI
UT WOS:000326007600010
PM 23571030
DA 2025-06-11
ER

PT J
AU Kang, SY
   Lee, JA
   Sunwoo, S
   Yu, BY
   Lee, JH
   Cho, CH
   Yoo, BW
   Jeon, TH
   Park, HK
   Kim, YS
AF Kang, Seo Young
   Lee, Jung Ah
   Sunwoo, Sung
   Yu, Byung-Yeon
   Lee, Jun Hyung
   Cho, Chung Hwan
   Yoo, Byung-wook
   Jeon, Tae Hee
   Park, Hoon Ki
   Kim, Young Sik
TI Prevalence of Sexual Dysfunction and Associated Risk Factors in
   Middle-Aged and Elderly Korean Men in Primary Care
SO JOURNAL OF SEX RESEARCH
LA English
DT Article
ID LATE-ONSET HYPOGONADISM; ERECTILE DYSFUNCTION; PREMATURE-EJACULATION;
   METABOLIC SYNDROME; ATTITUDES; OBESITY; DEPRESSION; DEFICIENCY; LIFE
AB Although several studies have individually investigated the risk factors for erectile dysfunction (ED), premature ejaculation (PE), and late-onset hypogonadism (LOH), few studies have considered ED, PE, and LOH as categories of sexual dysfunction (SD) within the same population. We therefore aimed to investigate the prevalence of SD and its associated risk factors among men in primary care. Study participants were enrolled by 18 family physicians from 15 hospital-based family practices in Korea between August 2010 and May 2011. Participants answered a questionnaire regarding their demographic characteristics and lifestyle factors as well as the Korean versions of the Androgen Deficiency in the Aging Male, the International Index of Erectile Function, and the Premature Ejaculation Diagnostic Tool questionnaires. SD prevalence was 64.9% among study participants who were 40years of age. ED prevalence was 43.7%, PE prevalence was 38.6%, and LOH prevalence was 16.8%. SD prevalence was significantly associated with increased age, overweight, hypertension, diabetes, and depression. These findings highlight the importance of screening questions for SD in primary care, especially among older male patients with the identified risk factors.
C1 [Kang, Seo Young; Lee, Jung Ah; Sunwoo, Sung; Kim, Young Sik] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Family Med, 88,Olymp Ro 43 Gil, Seoul 05505, South Korea.
   [Yu, Byung-Yeon] Konyang Univ, Coll Med, Konyang Univ Hosp, Dept Family Med, Nonsan, South Korea.
   [Lee, Jun Hyung] Inje Univ, Coll Med, Ilsan Paik Hosp, Dept Family Med, Gimhae, South Korea.
   [Cho, Chung Hwan] Jeonju Jesus Hosp, Dept Family Med, Jeonju, South Korea.
   [Yoo, Byung-wook] Soonchunhyang Univ, Coll Med, Soonchunhyang Univ Hosp Seoul, Dept Family Med, Asan, South Korea.
   [Jeon, Tae Hee] Cent Vet Hosp, Dept Family Med, Seoul, South Korea.
   [Park, Hoon Ki] Hanyang Univ, Coll Med, Hanyang Univ Hosp, Dept Family Med, Seoul, South Korea.
C3 University of Ulsan; Asan Medical Center; Konyang University; Konyang
   University Hospital; Inje University; Soonchunhyang University;
   Soonchunhyang University Hospital; Hanyang University; Hanyang
   University Hospital
RP Kim, YS (corresponding author), Univ Ulsan, Coll Med, Asan Med Ctr, Dept Family Med, 88,Olymp Ro 43 Gil, Seoul 05505, South Korea.
EM youngkim@amc.seoul.kr
OI Kang, Seo Young/0000-0002-7177-7816
FU Bayer Korea
FX This study was a follow-on study of the prevalence and correlates of
   late-onset hypogonadism among Korean men aged 40 years or older in
   primary care study. This study was supported in part by Bayer Korea.
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NR 42
TC 7
Z9 8
U1 0
U2 12
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 0022-4499
EI 1559-8519
J9 J SEX RES
JI J. Sex Res.
PD NOV-DEC
PY 2016
VL 53
IS 9
BP 1165
EP 1178
DI 10.1080/00224499.2016.1174657
PG 14
WC Psychology, Clinical; Social Sciences, Interdisciplinary
WE Social Science Citation Index (SSCI)
SC Psychology; Social Sciences - Other Topics
GA EA2ZG
UT WOS:000386465700011
PM 27215144
DA 2025-06-11
ER

PT J
AU Brogi, S
   Tabanelli, R
   Puca, S
   Calderone, V
AF Brogi, Simone
   Tabanelli, Rita
   Puca, Sara
   Calderone, Vincenzo
TI Intermittent Fasting: Myths, Fakes and Truth on This Dietary Regimen
   Approach
SO FOODS
LA English
DT Review
DE intermittent fasting (IF); alternate day fasting (ADF); time-restricted
   feeding (TRF); obesity; dietary regimen
ID DENSITY-LIPOPROTEIN CHOLESTEROL; RANDOMIZED CONTROLLED-TRIAL; TYPE-2
   DIABETES-MELLITUS; CALORIE-RESTRICTION; WEIGHT-LOSS; ALTERNATE-DAY;
   BODY-COMPOSITION; ENERGY RESTRICTION; COGNITIVE PERFORMANCE;
   BLOOD-CONSTITUENTS
AB Intermittent fasting (IF) has been indicated as a valuable alternative to the classical caloric restriction dietary regimen for lowering body weight and preventing obesity-related complications, such as metabolic syndrome and type II diabetes. However, is it effective? In this review article, we analyzed over 50 clinical studies in which IF, conducted by alternate day fasting (ADF) or time-restricted feeding (TRF), was compared with the caloric restriction approach. We evaluated the different roles of IF in treating and preventing human disorders such as metabolic syndrome, type II diabetes, and some types of cancer, as well as the usefulness of IF in reducing body weight and cardiovascular risk factors such as hypertension. Furthermore, we explored the cellular pathways targeted by IF to exert their beneficial effects by activating effector proteins that modulate cell functions and resistance to oxidative stress. In contrast, we investigated concerns regarding human health related to the adoption of IF dietary regimens, highlighting the profound debate surrounding weight loss regimens. We examined and compared several clinical trials to formulate an updated concept regarding IF and its therapeutic potential.
C1 [Brogi, Simone; Tabanelli, Rita; Puca, Sara; Calderone, Vincenzo] Univ Pisa, Dept Pharm, Via Bonanno 6, I-56126 Pisa, Italy.
   [Brogi, Simone] Isfahan Univ Med Sci, Bioinformat Res Ctr, Sch Pharm & Pharmaceut Sci, Esfahan 8174673461, Iran.
C3 University of Pisa; Isfahan University of Medical Sciences
RP Brogi, S (corresponding author), Univ Pisa, Dept Pharm, Via Bonanno 6, I-56126 Pisa, Italy.; Brogi, S (corresponding author), Isfahan Univ Med Sci, Bioinformat Res Ctr, Sch Pharm & Pharmaceut Sci, Esfahan 8174673461, Iran.
EM simone.brogi@unipi.it; ritatabanelli@gmail.com;
   saravictorlive@hotmail.it; vincenzo.calderone@unipi.it
RI Calderone, Vincenzo/L-9288-2015; Brogi, Simone/AAP-4179-2020
OI Brogi, Simone/0000-0001-9375-6242
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NR 206
TC 4
Z9 4
U1 8
U2 15
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2304-8158
J9 FOODS
JI Foods
PD JUL
PY 2024
VL 13
IS 13
AR 1960
DI 10.3390/foods13131960
PG 44
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA YO9G2
UT WOS:001269538800001
PM 38998465
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Campisano, S
   La Colla, A
   Echarte, SM
   Chisari, AN
AF Campisano, Sabrina
   La Colla, Anabela
   Echarte, Stella M.
   Chisari, Andrea N.
TI Interplay between early-life malnutrition, epigenetic modulation of the
   immune function and liver diseases
SO NUTRITION RESEARCH REVIEWS
LA English
DT Review
DE Early malnutrition; Epigenetics; Immune response; Liver disease
ID HEPATIC STELLATE CELLS; TOLL-LIKE RECEPTORS; HIGH-FAT DIET; KAPPA-B
   ACTIVATION; NONALCOHOLIC STEATOHEPATITIS; HEPATOCELLULAR-CARCINOMA;
   DENDRITIC CELLS; DEVELOPMENTAL ORIGINS; SUPPRESSOR-CELLS; OXIDATIVE
   STRESS
AB Early-life nutrition plays a critical role in fetal growth and development. Food intake absence and excess are the two main types of energy malnutrition that predispose to the appearance of diseases in adulthood, according to the hypothesis of 'developmental origins of health and disease'. Epidemiological data have shown an association between early-life malnutrition and the metabolic syndrome in later life. Evidence has also demonstrated that nutrition during this period of life can affect the development of the immune system through epigenetic mechanisms. Thus, epigenetics has an essential role in the complex interplay between environmental factors and genetics. Altogether, this leads to the inflammatory response that is commonly seen in non-alcoholic fatty liver disease (NAFLD), the hepatic manifestation of the metabolic syndrome. In conjunction, DNA methylation, covalent modification of histones and the expression of non-coding RNA are the epigenetic phenomena that affect inflammatory processes in the context of NAFLD. Here, we highlight current understanding of the mechanisms underlying developmental programming of NAFLD linked to epigenetic modulation of the immune system and environmental factors, such as malnutrition.
C1 [Campisano, Sabrina; La Colla, Anabela; Echarte, Stella M.; Chisari, Andrea N.] Univ Nacl Mar Del Plata, Dept Quim, Fac Ciencias Exactas & Nat, RA-7600 Mar Del Plata, Buenos Aires, Argentina.
C3 National University of Mar del Plata
RP Chisari, AN (corresponding author), Univ Nacl Mar Del Plata, Dept Quim, Fac Ciencias Exactas & Nat, RA-7600 Mar Del Plata, Buenos Aires, Argentina.
EM achisari@mdp.edu.ar
OI Chisari, Andrea/0000-0001-9351-0138
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NR 234
TC 39
Z9 40
U1 0
U2 28
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0954-4224
EI 1475-2700
J9 NUTR RES REV
JI Nutr. Res. Rev.
PD JUN
PY 2019
VL 32
IS 1
BP 128
EP 145
DI 10.1017/S0954422418000239
PG 18
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA HX5HU
UT WOS:000467432600008
PM 30707092
OA Green Published
DA 2025-06-11
ER

PT J
AU Li, Z
   Miard, S
   Laplante, M
   Sonenberg, N
   Picard, F
AF Li, Zhuo
   Miard, Stephanie
   Laplante, Mathieu
   Sonenberg, Nahum
   Picard, Frederic
TI Insulin stimulates IGFBP-2 expression in 3T3-L1 adipocytes through the
   PI3K/mTOR pathway
SO MOLECULAR AND CELLULAR ENDOCRINOLOGY
LA English
DT Article
DE Mouse; 3T3-L1; mTOR; Gene expression; Chromatin immunoprecipitation;
   C/EBP alpha
ID FACTOR-BINDING PROTEIN-2; DIET-INDUCED OBESITY; MTOR COMPLEX 1; I IGF-I;
   ADIPOSE-TISSUE; CELLULAR-DISTRIBUTION; HORMONAL-REGULATION; METABOLIC
   SYNDROME; OXIDATIVE STRESS; MESSENGER-RNAS
AB Insulin-like growth factor binding protein 2 (IGFBP-2) has been implicated in the etiology of several diseases, including the metabolic syndrome. Although IGFBP-2 derives mostly from the liver, recent evidence in mice and humans indicate that aging and obesity are associated with altered IGFBP-2 levels in white adipocytes. The present study was aimed at determining the mechanisms that control IGFBP-2 expression in mature adipocytes. IGFBP-2 mRNA and protein expression in serum-deprived 3T3-L1 adipocytes were twofold increased by acute insulin treatment. Co-treatments with the phosphatidylinositol 3-kinase (PI3K) inhibitor wortmannin or the mammalian target of rapamycin (mTOR) inhibitor rapamycin blunted the effects of insulin. Coherently, IGFBP-2 mRNA levels were robustly increased in adipocytes lacking either TSC2 or 4E-BP1. Insulin triggered the recruitment of CAAT/enhancer binding protein alpha (C/EBP alpha) to the IGFBP-2 proximal promoter. These findings suggest that insulin upregulates IGFBP-2 expression through a PI3K/mTOR/C/EBP alpha pathway in white adipocytes. (c) 2012 Elsevier Ireland Ltd. All rights reserved.
C1 [Li, Zhuo; Miard, Stephanie; Laplante, Mathieu; Picard, Frederic] Univ Laval, Inst Univ Cardiol & Pneumol Quebec, Ctr Rech, Ste Foy, PQ G1V 4G5, Canada.
   [Sonenberg, Nahum] McGill Univ, Dept Biochem, Montreal, PQ H3A 2T5, Canada.
C3 Laval University; Laval University Hospital; McGill University
RP Picard, F (corresponding author), Univ Laval, Inst Univ Cardiol & Pneumol Quebec, Ctr Rech, Y3106 Pavillon Marguerite dYouville,2725 Chemin, Ste Foy, PQ G1V 4G5, Canada.
EM Frederic.Picard@criucpq.ulaval.ca
RI Sonenberg, Nahum/AFN-8144-2022
FU CIHR [MOP-66967, CCI-85677]
FX We thank Dr. David Kwiatkowski and Dr. Katherine Cianflone for their
   generous help on providing MEFs cell lines, and Louise Boivin for expert
   technical assistance. F. Picard holds a FRSQ Junior 2 Investigator
   Award. This work was supported by operating grants from the CIHR
   (MOP-66967 and CCI-85677).
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NR 46
TC 13
Z9 13
U1 0
U2 4
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0303-7207
J9 MOL CELL ENDOCRINOL
JI Mol. Cell. Endocrinol.
PD JUL 6
PY 2012
VL 358
IS 1
BP 63
EP 68
DI 10.1016/j.mce.2012.02.022
PG 6
WC Cell Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Endocrinology & Metabolism
GA 950GY
UT WOS:000304638800008
PM 22410287
OA Green Published
DA 2025-06-11
ER

PT J
AU Ando, K
   Fujita, M
AF Ando, Katsuyuki
   Fujita, Megumi
TI Reactive oxygen species and the central nervous system in salt-sensitive
   hypertension: possible relationship with obesity-induced hypertension
SO CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
LA English
DT Article
DE central nervous system; obesity; rat models of hypertension; reactive
   oxygen species; sodium balance
ID ANGIOTENSIN-ALDOSTERONE SYSTEM; ARTERIAL-PRESSURE ELEVATION; REGIONAL
   BLOOD-FLOW; BODY-MASS INDEX; OXIDATIVE STRESS; METABOLIC SYNDROME;
   MINERALOCORTICOID RECEPTORS; BAROREFLEX IMPAIRMENT; SYMPATHETIC
   ACTIVITY; SODIUM-REABSORPTION
AB 1. There are multiple and complex mechanisms of salt-induced hypertension; however, central sympathoexcitation plays an important role. In addition, the production of reactive oxygen species (ROS) is increased in salt-sensitive hypertensive humans and animals. Thus, we hypothesized that brain ROS overproduction may increase blood pressure (BP) by central sympathostimulation.
   2. Recently, we demonstrated that ROS levels were elevated in the hypothalamus of salt-sensitive hypertensive animals. Moreover, intracerebroventricular anti-oxidants suppressed BP and renal sympathetic nerve activity more in salt-sensitive than nonsalt- sensitive hypertensive rats. Thus, brain ROS overproduction increased BP through central sympathoexcitation in salt-sensitive hypertension.
   3. Salt sensitivity of BP is enhanced in obesity and metabolic syndrome. Interestingly, it is also suggested that, in obesityinduced hypertension models, increases in BP are caused by brain ROS-induced central sympathoexcitation.
   4. Recent studies suggest that increased ROS production in the brain and central sympathoexcitation may share a common pathway that increases BP in both salt-and obesity-induced hypertension.
C1 [Ando, Katsuyuki] Univ Tokyo, Grad Sch Med, Dept Nephrol & Endocrinol, Bunkyo Ku, Tokyo 1138655, Japan.
C3 University of Tokyo
RP Ando, K (corresponding author), Univ Tokyo, Grad Sch Med, Dept Nephrol & Endocrinol, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1138655, Japan.
EM katsua-tky@umin.ac.jp
FU Grants-in-Aid for Scientific Research [21790797, 22590908] Funding
   Source: KAKEN
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NR 69
TC 26
Z9 30
U1 2
U2 14
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0305-1870
J9 CLIN EXP PHARMACOL P
JI Clin. Exp. Pharmacol. Physiol.
PD JAN
PY 2012
VL 39
IS 1
BP 111
EP 116
DI 10.1111/j.1440-1681.2011.05510.x
PG 6
WC Pharmacology & Pharmacy; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Physiology
GA 868RI
UT WOS:000298541600018
PM 21388436
DA 2025-06-11
ER

PT J
AU Renke, G
   Starling-Soares, B
   Baesso, T
   Petronio, R
   Aguiar, D
   Paes, R
AF Renke, Guilherme
   Starling-Soares, Bernardo
   Baesso, Thomaz
   Petronio, Rayssa
   Aguiar, Danilo
   Paes, Raphaela
TI Effects of Vitamin D on Cardiovascular Risk and Oxidative Stress
SO NUTRIENTS
LA English
DT Review
DE cardiovascular; vitamin D; 25-hydroxyvitamin D [25(OH)D]; 1;
   25-dihydroxycholecalciferol [1; 25(OH)2D]; calcitriol; oxidative stress
ID PARATHYROID-HORMONE LEVELS; SERUM 25-HYDROXYVITAMIN D; 3RD
   NATIONAL-HEALTH; BLOOD-PRESSURE; METABOLIC SYNDROME; D DEFICIENCY;
   INCIDENT HYPERTENSION; D SUPPLEMENTATION; ENDOTHELIAL DYSFUNCTION;
   ARTERIAL STIFFNESS
AB Introduction: Vitamin D has been primarily studied as an important factor influencing bone and calcium metabolism. Metabolites of vitamin D are essential for whole-body calcium homeostasis, maintaining serum calcium levels within a narrow range by regulating this process in the bones and gut. Nevertheless, its deficiency is also related to increased risk of type 2 diabetes mellitus (T2DM), metabolic syndrome (MS), and cardiovascular disease (CVD)-with increased visceral adipose tissue and body mass index (BMI), as well as the frequently associated hypercholesterolemia. It has been reported that vitamin D levels are inversely related to cardiovascular (CV) risk in men and women. However, the effects of vitamin D on distinct outcomes in women and the dose of supplementation needed to improve clinical endpoints have not been established. 25-Hydroxyvitamin D [25(OH)D] reduces systemic inflammatory mediators in CVD and favors the release of anti-inflammatory cytokines from the immune system. In addition, 25(OH)D can be primarily converted into calcitriol (1,25-dihydroxycholecalciferol [1,25(OH)2D]) in the kidneys through the action of the 1-alpha-hydroxylase enzyme. Calcitriol, through the downregulation mechanism of renin expression, renin-angiotensin-aldosterone system (RAAS) activity, and its interaction with the vitamin D receptor, can bring CV benefits. The calcitriol form also lowers parathyroid hormone (PTH) levels by indirectly causing a reduction in aldosterone and mineralocorticoid synthesis. Elevated plasma aldosterone is related to endothelial dysfunction and CVD in hypovitaminosis D status. Conclusion: Vitamin D supplementation may benefit certain risk groups, as it improves metabolic variables, reducing oxidative stress and CV outcomes. More studies are needed to define interventions with vitamin D in men and women.
C1 [Renke, Guilherme] Brazilian Minist Hlth, Natl Inst Cardiol, BR-21040900 Rio De Janeiro, Brazil.
   [Renke, Guilherme; Baesso, Thomaz; Petronio, Rayssa; Aguiar, Danilo; Paes, Raphaela] Nutrindo Ideais Performance & Nutr Res Ctr, BR-22640100 Rio De Janeiro, Brazil.
   [Starling-Soares, Bernardo] Extreme Sports Nutr Inst INEE, BR-31270901 Belo Horizonte, Brazil.
RP Renke, G (corresponding author), Brazilian Minist Hlth, Natl Inst Cardiol, BR-21040900 Rio De Janeiro, Brazil.; Renke, G (corresponding author), Nutrindo Ideais Performance & Nutr Res Ctr, BR-22640100 Rio De Janeiro, Brazil.
EM renke@renke.com.br
RI Renke, Guilherme/JKJ-2777-2023
OI Renke, Guilherme/0000-0002-7940-3667; , Instituto Nutrindo
   Ideais/0009-0007-9143-4697; Starling-Soares,
   Bernardo/0000-0002-0730-7684
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NR 89
TC 55
Z9 57
U1 6
U2 51
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD FEB
PY 2023
VL 15
IS 3
AR 769
DI 10.3390/nu15030769
PG 17
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 8V6ET
UT WOS:000930722700001
PM 36771474
OA Green Published, gold
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Phillips, SA
   Sylvester, FA
   Frisbee, JC
AF Phillips, SA
   Sylvester, FA
   Frisbee, JC
TI Oxidant stress and constrictor reactivity impair cerebral artery
   dilation in obese Zucker rats
SO AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE
   PHYSIOLOGY
LA English
DT Article
DE rat models of metabolic syndrome; microcirculation; cerebral
   circulation; vascular reactivity
ID SPONTANEOUSLY HYPERTENSIVE RATS; SKELETAL-MUSCLE; DIABETES-MELLITUS;
   OXIDATIVE STRESS; BASILAR ARTERY; NITRIC-OXIDE; RISK-FACTORS; DEPENDENT
   DILATATION; RESISTANCE ARTERIES; ALZHEIMERS-DISEASE
AB This study tested the hypothesis that evolution of the metabolic syndrome in obese Zucker rats (OZR) leads to impaired dilator reactivity of cerebral resistance arteries vs. responses determined in lean Zucker rats (LZR). Middle cerebral arteries (MCA) from 17-wk-old male LZR and OZR were isolated and cannulated with glass micropipettes. Vascular reactivity was assessed in response to challenge with ACh, sodium nitroprusside (SNP), reductions and elevations in PO2, 5-HT, and increased intralumenal pressure. Vessels were treated with the free radical scavenger 4-hydroxy-2,2,6,6- tetramethylpiperidine 1-oxyl (tempol) to assess the role of superoxide production in altering reactivity, and passive vascular wall mechanics was assessed in each vessel. Vascular superoxide production was assessed in isolated arteries using fluorescence microscopy. Vessel dilation to ACh and hypoxia was impaired in OZR vs. LZR, although responses to SNP were normal. Vessel constriction to 5-HT, elevated PO2, and elevated intralumenal pressure was enhanced in OZR vs. LZR. Fluorescence microscopy demonstrated an increased superoxide production in arteries of OZR vs. LZR, correctable by incubation with tempol. Although treatment of vessels from OZR with tempol improved dilation to ACh and hypoxia, constrictor responses to 5-HT, elevated PO2, and pressure were not altered by tempol treatment. Indexes of vessel wall mechanics were comparable between groups. These results suggest that vasodilator reactivity of MCA of OZR in response to endothelium-dependent dilator stimuli is impaired vs. LZR and that this may represent a reduced bioavailability of signaling molecules due to oxidant scavenging. However, oxidative stress-independent increases in myogenic tone and constrictor reactivity may contribute to blunted dilator responses of cerebral microvessels.
C1 W Virginia Univ, Sch Med, Ctr Interdisciplinary Res Cardiovasc Sci, Dept Physiol & Pharmacol, Morgantown, WV 26506 USA.
   Med Coll Wisconsin, Dept Physiol, Milwaukee, WI 53226 USA.
   Grand Valley State Univ, Dept Biomed Sci, Allendale, MI 49401 USA.
C3 West Virginia University; Medical College of Wisconsin; Grand Valley
   State University
RP W Virginia Univ, Sch Med, Ctr Interdisciplinary Res Cardiovasc Sci, Dept Physiol & Pharmacol, POB 9105, Morgantown, WV 26506 USA.
EM jfrisbee@hsc.wvu.edu
OI Frisbee, Jefferson/0000-0003-2751-0599; Phillips,
   Shane/0000-0001-6030-2367
FU NIDDK NIH HHS [R01-DK-64668] Funding Source: Medline
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NR 55
TC 98
Z9 114
U1 0
U2 4
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0363-6119
EI 1522-1490
J9 AM J PHYSIOL-REG I
JI Am. J. Physiol.-Regul. Integr. Comp. Physiol.
PD FEB
PY 2005
VL 288
IS 2
BP R522
EP R530
DI 10.1152/ajpregu.00655.2004
PG 9
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA 885IC
UT WOS:000226149300027
PM 15514104
DA 2025-06-11
ER

PT S
AU Bueno-Antequera, J
   Munguía-Izquierdo, D
AF Bueno-Antequera, Javier
   Munguia-Izquierdo, Diego
BE Xiao, J
TI Exercise and Schizophrenia
SO PHYSICAL EXERCISE FOR HUMAN HEALTH
SE Advances in Experimental Medicine and Biology
LA English
DT Article; Book Chapter
DE Schizophrenia; Psychosis; Physical activity; Obesity; Physical fitness;
   Exercise
ID MAJOR DEPRESSIVE DISORDER; SEVERE MENTAL-ILLNESS; CARDIOVASCULAR
   RISK-FACTORS; BODY-MASS INDEX; PHYSICAL-ACTIVITY; CARDIORESPIRATORY
   FITNESS; BIPOLAR DISORDER; COHORT PROFILE; SEDENTARY BEHAVIOR; EPA
   GUIDANCE
AB Schizophrenia is a psychiatric disorder characterized by distortions of thinking and perception, with no strictly pathognomonic symptoms that can be divided into positive, negative, and cognitive symptom domains. People with schizophrenia have, between others, a reduced life expectancy and cardiorespiratory and muscular fitness and increased risk of cardiovascular disease, metabolic syndrome, obesity, hypertension, and hyperlipidemia compared to the general population. Furthermore, the economic burden of mental disorders including schizophrenia is evident and it is expected to increase to more than double by 2030. Therefore, reducing the growing burden of mental disorders such as schizophrenia should be a health priority. Improved prevention and treatment are two key factors that may reduce the burden of schizophrenia. Pharmacological- and psychotherapy-based interventions have been traditionally considered for treating schizophrenia disorders; however, there is an increasing amount of scientific evidence confirming that physical activity and physical exercise should be highly considered in prevention and treatment of schizophrenia disorders. In this chapter, we aim to summarize and discuss the research progress of physical activity and exercise in prevention and treatment of schizophrenia disorder. Specifically, we summarized and discussed the research progress of the prognostic use of physical activity for incident schizophrenia; the importance of other outcomes typically improved by physical activity/exercise such as obesity and fitness (cardiorespiratory and muscular fitness) for future schizophrenia; the research progress of the evidence of the benefits of exercise in people with schizophrenia disorders differentiating between effects of exercise on varied health outcomes, cognitive functioning, and cardiorespiratory fitness; and finally the clinical practice recommendations.
C1 [Bueno-Antequera, Javier; Munguia-Izquierdo, Diego] Univ Pablo de Olavide, Phys Performance Sports Res Ctr, Dept Sports & Comp Sci, Sect Phys Educ & Sports,Fac Sports Sci, Seville, Spain.
   [Bueno-Antequera, Javier; Munguia-Izquierdo, Diego] Univ Zaragoza, Res Grp Dev Movimiento Humano, Zaragoza, Spain.
   [Munguia-Izquierdo, Diego] Biomed Res Networking Ctr Frailty & Hlth Aging, Madrid, Spain.
C3 Universidad Pablo de Olavide; University of Zaragoza
RP Munguía-Izquierdo, D (corresponding author), Univ Pablo de Olavide, Phys Performance Sports Res Ctr, Dept Sports & Comp Sci, Sect Phys Educ & Sports,Fac Sports Sci, Seville, Spain.; Munguía-Izquierdo, D (corresponding author), Univ Zaragoza, Res Grp Dev Movimiento Humano, Zaragoza, Spain.; Munguía-Izquierdo, D (corresponding author), Biomed Res Networking Ctr Frailty & Hlth Aging, Madrid, Spain.
EM dmunizq@upo.es
RI Munguía-Izquierdo, Diego/H-6452-2013; Bueno-Antequera,
   Javier/H-5515-2015
OI Bueno-Antequera, Javier/0000-0001-8063-3980
FU Universidad Pablo de Olavide, Andalusian Government [CTS-948];
   Universidad Pablo de Olavide, Spain "A2. Ayudas Puente para la
   Concurrencia al Plan Estatal de I+D"; European University of Madrid,
   Catedra Real Madrid, Spain [P2017/RM08]; Biomedical Research Networking
   Centre on Frailty and Healthy Aging (CIBERFES); FEDER funds from the
   European Union [CB16/10/00477]; Spanish Ministry of Education
   [FPU13/05130]; Departamento de Innovacion, Investigacion y Universidad
   del Gobierno de Aragon y el Fondo Europeo de Desarrollo Regional
   Programa Operativo FEDER Aragon 2014-2020 "Construyendo Europa desde
   Aragon" [FPU13/05130]
FX The work was funded by Research Group CTS-948, Universidad Pablo de
   Olavide, Andalusian Government; Universidad Pablo de Olavide, Spain "A2.
   Ayudas Puente para la Concurrencia al Plan Estatal de I+D"; European
   University of Madrid, Catedra Real Madrid, Spain (funding project number
   P2017/RM08); Biomedical Research Networking Centre on Frailty and
   Healthy Aging (CIBERFES); and FEDER funds from the European Union
   (CB16/10/00477). JBA was supported by the Spanish Ministry of Education
   (grant number FPU13/05130) and by the Departamento de Innovacion,
   Investigacion y Universidad del Gobierno de Aragon y el Fondo Europeo de
   Desarrollo Regional Programa Operativo FEDER Aragon 2014-2020
   "Construyendo Europa desde Aragon" (reference number PUI/2018-337). The
   funders had no role in study design; collection, analysis, and
   interpretation of data; writing the report; and the decision to submit
   the report for publication.
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NR 95
TC 30
Z9 33
U1 4
U2 32
PU SPRINGER-VERLAG SINGAPORE PTE LTD
PI SINGAPORE
PA 152 BEACH ROAD, #21-01/04 GATEWAY EAST, SINGAPORE, 189721, SINGAPORE
SN 0065-2598
EI 2214-8019
BN 978-981-15-1792-1; 978-981-15-1791-4
J9 ADV EXP MED BIOL
JI Adv.Exp.Med.Biol.
PY 2020
VL 1228
BP 317
EP 332
DI 10.1007/978-981-15-1792-1_21
D2 10.1007/978-981-15-1792-1
PG 16
WC Medicine, Research & Experimental; Physiology; Sport Sciences
WE Book Citation Index – Science (BKCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Physiology; Sport Sciences
GA BQ5AS
UT WOS:000596720900021
PM 32342467
DA 2025-06-11
ER

PT J
AU Mehta, D
   Voisey, J
   Bruenig, D
   Harvey, W
   Morris, CP
   Lawford, B
   Young, RM
AF Mehta, Divya
   Voisey, Joanne
   Bruenig, Dagmar
   Harvey, Wendy
   Morris, Charles P.
   Lawford, Bruce
   Young, Ross McD
TI Transcriptome analysis reveals novel genes and immune networks
   dysregulated in veterans with PTSD
SO BRAIN BEHAVIOR AND IMMUNITY
LA English
DT Article
DE PTSD; Genome-wide; Veterans; Gene expression; Immune; Networks
ID POSTTRAUMATIC-STRESS-DISORDER; METABOLIC SYNDROME; TRAUMA EXPOSURE;
   EXPRESSION; RISK; BRAIN; BLOOD; POLYMORPHISMS; PREVALENCE; DEPRESSION
AB Background: Posttraumatic stress disorder (PTSD) is a serious condition that emerges following trauma exposure and involves long-lasting psychological suffering and health-issues. Uncovering critical genes and molecular networks is essential to understanding the biology of the disorder. We performed a genome-wide scan to identify transcriptome signatures of PTSD.
   Methods: Genome-wide peripheral blood transcriptomic data from 380 service personnel were investigated. This included a discovery sample of 96 Australian Vietnam War veterans and two independent pre and post-deployment replication samples of U.S. Marines (N = 188 and N = 96).
   Results: A total of 60 transcripts were differentially expressed between veterans with and without PTSD, surviving Bonferroni multiple testing correction. Genes within the cytokine-cytokine receptor interaction, Jak-STAT signaling and Toll-like receptor signaling pathways were enriched. For 49% of the genes, gene expression changes were also accompanied by DNA methylation changes. Using replication data from two U.S. Marine cohorts, we observed that of the differentially expressed genes, 71% genes also showed significant gene expression changes between pre and post-deployment. Weighted gene co-expression networks revealed two modules of genes associated with PTSD. The first module (67 genes, p-value = 6e-4) was enriched for genes within the 11p13 locus including BDNF. The second module (266 genes, p-value = 0.01) was enriched for genes in 17q11 including SLC6A4, STATSA and STAT5B.
   Conclusions: We identified novel transcriptomic loci and biological pathways for PTSD in service personnel. Network analysis revealed enrichment of loci harboring key candidate genes in PTSD. These findings highlight the role of transcriptional biomarkers in the molecular etiology of PTSD.
C1 [Mehta, Divya] Queensland Univ Technol, Inst Hlth & Biomed Innovat, Sch Psychol & Counselling, Fac Hlth, 60 Musk Ave, Kelvin Grove, Qld 4059, Australia.
   [Voisey, Joanne; Bruenig, Dagmar; Morris, Charles P.; Lawford, Bruce] Queensland Univ Technol, Inst Hlth & Biomed Innovat, Fac Hlth, Sch Biomed Sci, Kelvin Grove, Qld, Australia.
   [Bruenig, Dagmar; Harvey, Wendy; Lawford, Bruce] Greenslopes Private Hosp, Gallipoli Med Res Fdn, Newdegate St, Greenslopes, Qld 4120, Australia.
   [Young, Ross McD] Queensland Univ Technol, Inst Hlth & Biomed Innovat, Fac Hlth, Kelvin Grove, Qld, Australia.
C3 Queensland University of Technology (QUT); Queensland University of
   Technology (QUT); Gallipoli Medical Research Foundation; Greenslopes
   Private Hospital; Queensland University of Technology (QUT)
RP Mehta, D (corresponding author), Queensland Univ Technol, Inst Hlth & Biomed Innovat, Sch Psychol & Counselling, Fac Hlth, 60 Musk Ave, Kelvin Grove, Qld 4059, Australia.
EM divya.mehta@qut.edu.au
RI Voisey, Joanne/HTL-2238-2023; Young, Ross/AAF-2082-2021; Mehta,
   Divya/ABD-4551-2021
OI Young, Ross/0000-0002-6806-6503; Voisey, Joanne/0000-0001-6645-6164;
   Mehta, Divya/0000-0001-7971-7255; Mehta, Divya
   Deepak/0000-0002-7359-348X; Bruenig, Dagmar/0000-0002-3760-7098
FU Queensland Branch of the Returned and Services League of Australia (RSL
   QLD), Australia; Faculty of Health QUT; IHBI; QUT Vice Chancellors
   Research Fellowship; Gallipoli Medical Research Foundation
FX The authors thank the Gallipoli Medical Research Foundation for their
   support, especially Miriam Dwyer and Dr Sarah McLeay for their project
   management support. The authors would also like to acknowledge Dr
   Madeline Romaniuk for psychological expertise and Dr John Gibson and the
   team at the Keith Payne Unit, and the staff and investigators at
   Greenslopes Private Hospital for their valuable contribution to the
   study. All authors extend their gratitude to the study participants for
   their generous provision of data and time. The PTSD Initiative was
   funded by the Queensland Branch of the Returned and Services League of
   Australia (RSL QLD), Australia. The Gallipoli Medical Research
   Foundation wishes to thank the RSL QLD for their generous donation, and
   Sullivan Nicolaides Pathology and Queensland X-Ray for their in-kind
   support. The authors thank The Faculty of Health QUT, and IHBI for
   financial and administrative support. Divya Mehta was funded via the QUT
   Vice Chancellors Research Fellowship.
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U1 1
U2 10
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0889-1591
EI 1090-2139
J9 BRAIN BEHAV IMMUN
JI Brain Behav. Immun.
PD NOV
PY 2018
VL 74
BP 133
EP 142
DI 10.1016/j.bbi.2018.08.014
PG 10
WC Immunology; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Neurosciences & Neurology; Psychiatry
GA HF4FB
UT WOS:000454187500015
PM 30189241
DA 2025-06-11
ER

PT J
AU Santana, LF
   Inada, AC
   Santo, BLSD
   Filiú, WFO
   Pott, A
   Alves, FM
   Guimaraes, RDA
   Freitas, KD
   Hiane, PA
AF Santana, Lidiani F.
   Inada, Aline C.
   Spontoni do Espirito Santo, Bruna Larissa
   Filiu, Wander F. O.
   Pott, Arnildo
   Alves, Flavio M.
   Guimaraes, Rita de Cassia A.
   Freitas, Karine de Cassia
   Hiane, Priscila A.
TI Nutraceutical Potential of Carica papaya in Metabolic Syndrome
SO NUTRIENTS
LA English
DT Review
DE blood glucose; food composition; metabolic syndrome; natural products;
   Carica papaya
ID OXIDATIVE STRESS; BENZYL ISOTHIOCYANATE; AQUEOUS EXTRACT;
   PHENOLIC-COMPOUNDS; ACE ACTIVITY; CANCER; LEAF; L.; ETHANOL; LINN
AB Carica papaya L. is a well-known fruit worldwide, and its highest production occurs in tropical and subtropical regions. The pulp contains vitamins A, C, and E, B complex vitamins, such as pantothenic acid and folate, and minerals, such as magnesium and potassium, as well as food fibers. Phenolic compounds, such as benzyl isothiocyanate, glucosinolates, tocopherols (alpha and delta), beta-cryptoxanthin, beta-carotene and carotenoids, are found in the seeds. The oil extracted from the seed principally presents oleic fatty acid followed by palmitic, linoleic and stearic acids, whereas the leaves have high contents of food fibers and polyphenolic compounds, flavonoids, saponins, pro-anthocyanins, tocopherol, and benzyl isothiocyanate. Studies demonstrated that the nutrients present in its composition have beneficial effects on the cardiovascular system, protecting it against cardiovascular illnesses and preventing harm caused by free radicals. It has also been reported that it aids in the treatment of diabetes mellitus and in the reduction of cholesterol levels. Thus, both the pulp and the other parts of the plant (leaves and seeds) present antioxidant, anti-hypertensive, hypoglycemic, and hypolipidemic actions, which, in turn, can contribute to the prevention and treatment of obesity and associated metabolic disorders.
C1 [Santana, Lidiani F.; Inada, Aline C.; Spontoni do Espirito Santo, Bruna Larissa; Guimaraes, Rita de Cassia A.; Freitas, Karine de Cassia; Hiane, Priscila A.] Fed Univ Mato Grosso Sul UFMS, Grad Program Hlth & Dev Cent West Reg Brazil, BR-79079900 Campo Grande, MS, Brazil.
   [Filiu, Wander F. O.] Fed Univ Mato Grosso Sul UFMS, Fac Ciencias Farmaceut Alimentos & Nutr, BR-79079900 Campo Grande, MS, Brazil.
   [Pott, Arnildo; Alves, Flavio M.] Fed Univ Mato Grosso Sul UFMS, Inst Biosci, BR-79079900 Campo Grande, MS, Brazil.
C3 Universidade Federal de Mato Grosso do Sul; Universidade Federal de Mato
   Grosso do Sul; Universidade Federal de Mato Grosso do Sul
RP Freitas, KD (corresponding author), Fed Univ Mato Grosso Sul UFMS, Grad Program Hlth & Dev Cent West Reg Brazil, BR-79079900 Campo Grande, MS, Brazil.
EM kcfreitas@gmail.com
RI Guimarães, Rita de Cássia/JVO-6281-2024; POTT, ARNILDO/I-5759-2012;
   Alves, Flavio/A-7584-2013
OI HIANE, PRISCILA AIKO/0000-0003-1115-4083; Alves,
   Flavio/0000-0001-5634-8266; Inada, Aline/0000-0001-6788-9172
FU graduate program in Health and Development in the Central-West Region of
   Brazil, Federal University of Mato Grosso do Sul-UFMS
FX We thank the graduate program in Health and Development in the
   Central-West Region of Brazil, Federal University of Mato Grosso do
   Sul-UFMS, for support.
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NR 87
TC 79
Z9 82
U1 3
U2 26
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JUL
PY 2019
VL 11
IS 7
AR 1608
DI 10.3390/nu11071608
PG 19
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA IN7TT
UT WOS:000478885400095
PM 31315213
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Ranhotra, HS
AF Ranhotra, Harmit S.
TI The interplay between retinoic acid receptor-related orphan receptors
   and human diseases
SO JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION
LA English
DT Review
DE Orphan nuclear receptors; metabolic syndrome; autoimmunity; inflammation
ID ROR-GAMMA-T; LYMPHOID ORGAN DEVELOPMENT; NUCLEAR HORMONE-RECEPTORS;
   LIVER-X-RECEPTOR; GENE-EXPRESSION; DRUG-METABOLISM; TRANSCRIPTIONAL
   REGULATION; XENOBIOTIC RESPONSE; IMMUNE-RESPONSE; STRESS-RESPONSE
AB The retinoic acid receptor-related orphan receptors (RORs) are an important subfamily of transcriptional regulators of the nuclear receptors superfamily. Their discovery over a decade ago by gene cloning strategy have revealed three major isoforms of these orphan receptors in animals. Generation and analyses of isoform-specific ROR null mice have provided revealed-vital roles for the RORs in animals. The RORs undoubtedly participate in a host of biological functions such a metabolism, immunity, development and differentiation, angiogenesis, circadian clock, xenobiotic/drug metabolism and other tissue physiologies for optimal animal survival. Moreover, intense work in the last one decade also revealed a host of human diseases being modulated by the RORs. A number of diseases, such as cancer, autoimmune diseases, inflammation, osteoporosis, metabolic syndrome etc., strongly support the involvement of RORs in their onset and progression. By involving in such diseases, the RORs are indeed a critical factor for optimal cell function and are being intensely investigated as novel targets for drug interventions in the treatment of various diseases. This review focuses on the current knowledge and status about RORs in a number of human disease conditions.
C1 St Edmunds Coll, Dept Biochem, Orphan Nucl Receptors Lab, Shillong 793003, Meghalaya, India.
RP Ranhotra, HS (corresponding author), St Edmunds Coll, Dept Biochem, Orphan Nucl Receptors Lab, Shillong 793003, Meghalaya, India.
EM harmitran@gmail.com
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NR 90
TC 10
Z9 12
U1 0
U2 12
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 1079-9893
J9 J RECEPT SIG TRANSD
JI J. Recept. Signal Transduct.
PD AUG
PY 2012
VL 32
IS 4
BP 181
EP 189
DI 10.3109/10799893.2012.692120
PG 9
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA 975QM
UT WOS:000306526000002
PM 22686165
DA 2025-06-11
ER

PT J
AU Denisenko, YK
   Kytikova, OY
   Novgorodtseva, TP
   Antonyuk, MV
   Gvozdenko, TA
   Kantur, TA
AF Denisenko, Yulia K.
   Kytikova, Oxana Yu
   Novgorodtseva, Tatyana P.
   Antonyuk, Marina V.
   Gvozdenko, Tatyana A.
   Kantur, Tatyana A.
TI Lipid-Induced Mechanisms of Metabolic Syndrome
SO JOURNAL OF OBESITY
LA English
DT Review
ID CHAIN FATTY-ACIDS; INSULIN-RESISTANCE; ADIPOSE-TISSUE;
   CARDIOVASCULAR-DISEASE; RESOLVIN D1; INFLAMMATION; RECEPTORS;
   PLASMALOGENS; OBESITY; OMEGA-3
AB Metabolic syndrome (MetS) has a worldwide tendency to increase and depends on many components, which explains the complexity of diagnosis, approaches to the prevention, and treatment of this pathology. Insulin resistance (IR) is the crucial cause of the MetS pathogenesis, which develops against the background of abdominal obesity. In light of recent evidence, it has been shown that lipids, especially fatty acids (FAs), are important signaling molecules that regulate the signaling pathways of insulin and inflammatory mediators. On the one hand, the lack of n-3 polyunsaturated fatty acids (PUFAs) in the body leads to impaired molecular mechanisms of glucose transport, the formation of unresolved inflammation. On the other hand, excessive formation of free fatty acids (FFAs) underlies the development of oxidative stress and mitochondrial dysfunction in MetS. Understanding the molecular mechanisms of the participation of FAs and their metabolites in the pathogenesis of MetS will contribute to the development of new diagnostic methods and targeted therapy for this disease. The purpose of this review is to highlight recent advances in the study of the effect of fatty acids as modulators of insulin response and inflammatory process in the pathogenesis and treatment for MetS.
C1 [Denisenko, Yulia K.; Kytikova, Oxana Yu; Novgorodtseva, Tatyana P.; Antonyuk, Marina V.; Gvozdenko, Tatyana A.] Inst Med Climatol & Rehabilitat Treatment, Vladivostok Branch, Far Eastern Sci Ctr Physiol & Pathol Respirat, Vladivostok 690105, Russia.
   [Kantur, Tatyana A.] Far Eastern Fed Univ, Vladivostok 690950, Russia.
C3 Far Eastern Federal University
RP Denisenko, YK (corresponding author), Inst Med Climatol & Rehabilitat Treatment, Vladivostok Branch, Far Eastern Sci Ctr Physiol & Pathol Respirat, Vladivostok 690105, Russia.
EM karaman@inbox.ru; kytikova@yandex.ru; curdeal@mail.ru;
   antonyukm@mail.ru; tagvozdenko@mail.ru; kanturovichi@yandex.ru
RI Antonyuk, Marina/I-4862-2016; kytikova, oxana/JCD-9123-2023; Gvozdenko,
   Tatyana/I-6374-2016; Novgorodtseva, Tatyana/E-9441-2016; Denisenko,
   Yulia/L-2292-2015
OI Kytikova, Oxana/0000-0001-5018-0271; Gvozdenko,
   Tatyana/0000-0002-6413-9840; Novgorodtseva, Tatyana/0000-0002-6058-201X;
   Denisenko, Yulia/0000-0003-4130-8899
FU Ministry of Education and Science of the Russian Federation
FX The study was funded by the Ministry of Education and Science of the
   Russian Federation.
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NR 112
TC 41
Z9 43
U1 2
U2 11
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2090-0708
EI 2090-0716
J9 J OBES
JI J. Obes.
PD AUG 26
PY 2020
VL 2020
AR 5762395
DI 10.1155/2020/5762395
PG 14
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA NQ6OJ
UT WOS:000570990600001
PM 32963827
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Foisy-Sauvé, M
   Ahmarani, L
   Delvin, E
   Sané, AT
   Spahis, S
   Levy, E
AF Foisy-Sauve, Mathilde
   Ahmarani, Lena
   Delvin, Edgard
   Sane, Alain T.
   Spahis, Schohraya
   Levy, Emile
TI Glycomacropeptide Prevents Iron/Ascorbate-Induced Oxidative Stress,
   Inflammation and Insulin Sensitivity with an Impact on Lipoprotein
   Production in Intestinal Caco-2/15 Cells
SO NUTRIENTS
LA English
DT Article
DE glycomacropeptide; oxidative stress; inflammation; insulin sensitivity;
   metabolic syndrome; milk-derived bioactive peptide
ID ACTIVATED PROTEIN-KINASE; DIET-INDUCED OBESITY; KAPPA-B ACTIVATION;
   HIGH-FAT DIET; CASEIN GLYCOMACROPEPTIDE; PHOSPHATIDYLINOSITOL 3-KINASE;
   BOVINE GLYCOMACROPEPTIDE; INCREASED SUSCEPTIBILITY; CHOLESTEROL
   ABSORPTION; SIGNALING PATHWAY
AB Background. Metabolic Syndrome (MetS), a major worldwide concern for the public health system, refers to a cluster of key metabolic components, and represents a risk factor for diabetes and cardiovascular diseases. As oxidative stress (OxS) and inflammation are the major triggers of insulin sensitivity (IS), a cardinal MetS feature, the principal aim of the present work is to determine whether glycomacropeptide (GMP), a milk-derived bioactive peptide, exerts beneficial effects on their expression. Methods. Fully differentiated intestinal Caco-2/15 cells are used to evaluate the preventive action of 2 mg/mL GMP against OxS and inflammation induced by the mixture iron-ascorbate (Fe/Asc) (200 mu M:2 mM). The potency of GMP of decreasing the production of lipoproteins, including chylomicrons (CM), very-low-density lipoproteins (VLDL) and low-density lipoproteins (LDL) is also assessed. Results. The administration of GMP significantly reduces malondialdehyde, a biomarker of lipid peroxidation, and raises superoxide dismutase 2 and glutathione peroxidase via the induction of the nuclear factor erythroid 2-related factor 2, a transcription factor, which orchestrates cellular antioxidant defenses. Similarly, GMP markedly lowers the inflammatory agents tumor necrosis factor-alpha and cyclooxygenase-2 via abrogation of the nuclear transcription factor-kB. Moreover, GMP-treated cells show a down-regulation of Fe/Asc-induced mitogen activated protein kinase pathway, suggesting greater IS. Finally, GMP decreases the production of CM, VLDL, and LDL. Conclusions. Our results highlight the effectiveness of GMP in attenuating OxS, inflammation and lipoprotein biogenesis, as well as improving IS, the key components of MetS. Further investigation is needed to elucidate the mechanisms mediating the preventive action of GMP.
C1 [Foisy-Sauve, Mathilde; Ahmarani, Lena; Delvin, Edgard; Sane, Alain T.; Spahis, Schohraya; Levy, Emile] CHU Ste Justine, Res Ctr, Montreal, PQ H3T 1C5, Canada.
   [Foisy-Sauve, Mathilde; Spahis, Schohraya; Levy, Emile] Univ Montreal, Dept Nutr, Montreal, PQ H3T 1A8, Canada.
C3 Universite de Montreal; Universite de Montreal
RP Levy, E (corresponding author), CHU Ste Justine, Res Ctr, Montreal, PQ H3T 1C5, Canada.; Levy, E (corresponding author), Univ Montreal, Dept Nutr, Montreal, PQ H3T 1A8, Canada.
EM mfois067@uottawa.ca; lena_ahm@yahoo.com; delvine@sympatico.ca;
   sanealaintheo@gmail.com; schohraya.spahis@recherche-ste-justine.qc.ca;
   emile.levy@recherche-ste-justine.qc.ca
OI Levy, Emile/0000-0001-9983-7027; Spahis, Schohraya/0000-0003-4130-4994;
   Delvin, Edgard/0000-0002-3130-7748
FU Dairy Farmers of Canada [E4839]; JA deSeve Research Chair in nutrition;
   FRQS/CIHR Master Scholarship Award
FX This research was funded by the Dairy Farmers of Canada (E4839) and the
   JA deSeve Research Chair in nutrition. M.F.-S. received a FRQS/CIHR
   Master Scholarship Award.
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TC 17
Z9 17
U1 2
U2 13
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD APR
PY 2020
VL 12
IS 4
AR 1175
DI 10.3390/nu12041175
PG 18
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA LL8VE
UT WOS:000531831300295
PM 32331475
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Nunes, CS
   Maes, M
   Roomruangwong, C
   Moraes, JB
   Bonifacio, KL
   Vargas, HO
   Barbosa, DS
   Anderson, G
   de Melo, LGP
   Drozdstoj, S
   Moreira, E
   Carvalho, AF
   Nunes, SOV
AF Nunes, Caroline Sampaio
   Maes, Michael
   Roomruangwong, Chutima
   Moraes, Juliana Brum
   Bonifacio, Kamila Landucci
   Vargas, Heber Odebrecht
   Barbosa, Decio Sabbatini
   Anderson, George
   Piccoli de Melo, Luiz Gustavo
   Drozdstoj, Stoyanov
   Moreira, Estefania
   Carvalho, Andre F.
   Vargas Nunes, Sandra Odebrecht
TI Lowered quality of life in mood disorders is associated with increased
   neuro-oxidative stress and basal thyroid-stimulating hormone levels and
   use of anticonvulsant mood stabilizers
SO JOURNAL OF EVALUATION IN CLINICAL PRACTICE
LA English
DT Article
DE bipolar disorder; child abuse; depressive disorder; quality of life;
   suicide; tobacco use disorder
ID BIPOLAR DISORDER; METABOLIC SYNDROME; CHILDHOOD MALTREATMENT; SYSTEMATIC
   ANALYSIS; MAJOR DEPRESSION; RISK-FACTORS; ANTIOXIDANT; HEALTH;
   DISABILITY; PATHWAYS
AB Rationale, aims Major affective disorders including bipolar disorder (BD) and major depressive disorder (MDD) are associated with impaired health-related quality of life (HRQoL). Oxidative stress and subtle thyroid abnormalities may play a pathophysiological role in both disorders. Thus, the current study was performed to examine whether neuro-oxidative biomarkers and thyroid-stimulating hormone (TSH) levels could predict HRQoL in BD and MDD.
   Methods This cross-sectional study enrolled 68 BD and 37 MDD patients and 66 healthy controls. The World Health Organization (WHO) QoL-BREF scale was used to assess 4 QoL subdomains. Peripheral blood malondialdehyde (MDA), advanced oxidation protein products, paraoxonaxe/CMPAase activity, a composite index of nitro-oxidative stress, and basal TSH were measured.
   Results In the total WHOQoL score, 17.3% of the variance was explained by increased advanced oxidation protein products and TSH levels and lowered CMPAase activity and male gender. Physical HRQoL (14.4%) was associated with increased MDA and TSH levels and lowered CMPAase activity. Social relations HRQoL (17.4%) was predicted by higher nitro-oxidative index and TSH values, while mental and environment HRQoL were independently predicted by CMPAase activity. Finally, 73.0% of the variance in total HRQoL was explained by severity of depressive symptoms, use of anticonvulsants, lower income, early lifetime emotional neglect, MDA levels, the presence of mood disorders, and suicidal ideation.
   Conclusions These data show that lowered HRQoL in major affective disorders could at least in part result from the effects of lipid peroxidation, protein oxidation, lowered antioxidant enzyme activities, and higher levels of TSH.
C1 [Nunes, Caroline Sampaio; Bonifacio, Kamila Landucci; Vargas, Heber Odebrecht; Piccoli de Melo, Luiz Gustavo; Vargas Nunes, Sandra Odebrecht] Univ Estadual Londrina, Hlth Sci Ctr, Dept Psychiat, Londrina, Parana, Brazil.
   [Maes, Michael; Moraes, Juliana Brum; Vargas, Heber Odebrecht; Barbosa, Decio Sabbatini; Piccoli de Melo, Luiz Gustavo; Moreira, Estefania; Vargas Nunes, Sandra Odebrecht] Univ Estadual Londrina, Hlth Sci Ctr, Hlth Sci Graduat Program, Londrina, Parana, Brazil.
   [Maes, Michael; Roomruangwong, Chutima] Chulalongkorn Univ, Dept Psychiat, Fac Med, Bangkok, Thailand.
   [Maes, Michael; Drozdstoj, Stoyanov] Med Univ Plovdiv, Dept Psychiat, Plovdiv, Bulgaria.
   [Maes, Michael] Deakin Univ, IMPACT Strateg Res Ctr, Geelong, Vic, Australia.
   [Vargas, Heber Odebrecht] Univ Estadual Londrina, Univ Hosp, Ctr Approach & Treatment Smokers, Londrina, Parana, Brazil.
   [Anderson, George] Clin Res Ctr Scotland & London, London, England.
   [Carvalho, Andre F.] Univ Toronto, Dept Psychiat, Toronto, ON, Canada.
   [Carvalho, Andre F.] Ctr Addict & Mental Hlth, Toronto, ON, Canada.
C3 Universidade Estadual de Londrina; Universidade Estadual de Londrina;
   Chulalongkorn University; Medical University Plovdiv; Deakin University;
   Universidade Estadual de Londrina; University of Toronto; University of
   Toronto; Centre for Addiction & Mental Health - Canada
RP Maes, M (corresponding author), Chulalongkorn Univ, Dept Psychiat, Fac Med, Bangkok, Thailand.
EM dr.michaelmaes@hotmail.com
RI de Melo, Luiz Gustavo Piccoli/C-2271-2018; Barbosa, Décio/AAE-6351-2019;
   Brum Moraes, Juliana/AAC-9950-2022; Maes, Michael/B-8546-2011; Carvalho,
   Andre/AEZ-4001-2022; Roomruangwong, Chutima/L-1317-2019; Moreira,
   Estefania/AAC-5959-2019; Anderson, George/AEO-3626-2022
OI Anderson, George/0000-0001-7243-0817; Brum Moraes,
   Juliana/0000-0002-3380-5900; Maes, Michael/0000-0002-2012-871X; Moreira,
   Estefania/0000-0001-8362-9557; Melo, Luiz Gustavo Piccoli
   de/0000-0002-1078-8044
FU Ministry for Science and Technology of Brazil (CNPq) [465928/2014-5,
   470344/2013-0]; Health Sciences Postgraduate Program at Londrina State
   University, Parana, Brazil (UEL)
FX Ministry for Science and Technology of Brazil (CNPq), Grant/Award
   Numbers: 465928/2014-5 and 470344/2013-0; Health Sciences Postgraduate
   Program at Londrina State University, Parana, Brazil (UEL)
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NR 72
TC 22
Z9 23
U1 0
U2 9
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1356-1294
EI 1365-2753
J9 J EVAL CLIN PRACT
JI J. Eval. Clin. Pract.
PD AUG
PY 2018
VL 24
IS 4
BP 869
EP 878
DI 10.1111/jep.12918
PG 10
WC Health Care Sciences & Services; Medical Informatics; Medicine, General
   & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services; Medical Informatics; General & Internal
   Medicine
GA GO6HQ
UT WOS:000440140900032
PM 29665163
DA 2025-06-11
ER

PT J
AU Holmannova, D
   Borska, L
   Andrys, C
   Borsky, P
   Kremlacek, J
   Hamakova, K
   Rehacek, V
   Malkov, A
   Svadlakova, T
   Palicka, V
   Krejsek, J
   Fiala, Z
AF Holmannova, Drahomira
   Borska, Lenka
   Andrys, Ctirad
   Borsky, Pavel
   Kremlacek, Jan
   Hamakova, Kvetoslava
   Rehacek, Vit
   Malkov, Andrea
   Svadlakova, Tereza
   Palicka, Vladimir
   Krejsek, Jan
   Fiala, Zdenek
TI The Impact of Psoriasis and Metabolic Syndrome on the Systemic
   Inflammation and Oxidative Damage to Nucleic Acids
SO JOURNAL OF IMMUNOLOGY RESEARCH
LA English
DT Article
ID CIRCULATING BETATROPHIN; DNA-DAMAGE; PATHOGENESIS; DISEASE; ANGPTL8;
   OBESITY; STRESS; CALPROTECTIN; EXPRESSION; CELLS
AB Background. Psoriasis is a chronic systemic inflammatory disease associated with a wide range of comorbidities, including metabolic syndrome (MetS). Serum calprotectin, ANGPTL8, and oxidative damage to nucleic acids might be associated with both diseases. The presented study describes the influence of psoriasis and MetS on the serum levels of markers of systemic inflammation (calprotectin and ANGPTL8) and markers of oxidative damage to nucleic acids. The applicability of serum levels of calprotectin and ANGPTL8 for monitoring of the activity of psoriasis (diagnostic markers) is also evaluated. Methods. Clinical examination (PASI score, MetS), enzyme-linked immunosorbent assay (ELISA), and Enzyme Immunoassay (EIA). Serum calprotectin, ANGPTL8, 8-hydroxy-2 '-deoxyguanosine, 8-hydroxyguanosine, and 8-hydroxyguanine. Results and Conclusions. The psoriasis significantly increased the serum level of calprotectin and the serum level of oxidative damage to nucleic acids, however not the serum level of ANGPTL8. The presence of MetS did not significantly affect the serum levels of calprotectin, ANGPTL8, and oxidative damage to nucleic acids in either psoriasis patients or controls. It seems that the serum level of calprotectin (but not the serum level of ANGPTL8) could be used as a biomarker for monitoring the activity of psoriasis.
C1 [Holmannova, Drahomira; Borsky, Pavel; Malkov, Andrea; Svadlakova, Tereza; Fiala, Zdenek] Charles Univ Prague, Fac Med Hradec Kralove, Inst Hyg & Prevent Med, Hradec Kralove, Czech Republic.
   [Borska, Lenka; Borsky, Pavel; Kremlacek, Jan] Charles Univ Prague, Fac Med Hradec Kralove, Inst Pathol Physiol, Hradec Kralove, Czech Republic.
   [Andrys, Ctirad; Svadlakova, Tereza; Krejsek, Jan] Charles Univ Prague, Univ Hosp, Inst Clin Immunol & Allergol, Hradec Kralove, Czech Republic.
   [Andrys, Ctirad; Svadlakova, Tereza; Palicka, Vladimir; Krejsek, Jan] Charles Univ Prague, Fac Med Hradec Kralove, Hradec Kralove, Czech Republic.
   [Hamakova, Kvetoslava] Univ Hosp Hradec Kralove, Clin Dermatol & Venereol, Hradec Kralove, Czech Republic.
   [Rehacek, Vit] Univ Hosp, Transfus Ctr, Hradec Kralove 50003, Czech Republic.
   [Palicka, Vladimir] Charles Univ Prague, Univ Hosp Hradec Kralove, Inst Clin Biochem & Diagnost, Hradec Kralove, Czech Republic.
C3 Charles University Prague; University Hospital Hradec Kralove;
   University Hospital Hradec Kralove; Charles University Prague; Charles
   University Prague; University Hospital Hradec Kralove; University
   Hospital Hradec Kralove; Charles University Prague; University Hospital
   Hradec Kralove; University Hospital Hradec Kralove; Charles University
   Prague; University Hospital Hradec Kralove
RP Borsky, P (corresponding author), Charles Univ Prague, Fac Med Hradec Kralove, Inst Hyg & Prevent Med, Hradec Kralove, Czech Republic.; Borsky, P (corresponding author), Charles Univ Prague, Fac Med Hradec Kralove, Inst Pathol Physiol, Hradec Kralove, Czech Republic.
EM borskyp@lfhk.cuni.cz
RI Krejsek, Jan/AAQ-6561-2021; Holmannova, Drahomira/G-6260-2017; Rehacek,
   Vit/H-4564-2018; Fiala, Zdeněk/E-5962-2017; Borsky, Pavel/S-6307-2016;
   Svadlakova, Tereza/E-5562-2017; Malkova, Andrea/B-1013-2017; Palicka,
   Vladimir/N-1802-2017; Kremlacek, Jan/A-4313-2008; Borska,
   Lenka/S-6304-2016
OI Andrys, Ctirad/0000-0001-6489-8786; Borsky, Pavel/0000-0001-5253-2808;
   Svadlakova, Tereza/0000-0002-1581-5531; Holmannova,
   Drahomira/0000-0002-9865-9991; Malkova, Andrea/0000-0001-9444-8065;
   Palicka, Vladimir/0000-0001-7236-1647; Kremlacek,
   Jan/0000-0001-8641-4287; Borska, Lenka/0000-0002-8580-1485
FU Charles University, Faculty of Medicine in Hradec Kralove, the Czech
   Republic [Q40-09, Q40-10, Q40-11, SVV-260397/2017]
FX The authors acknowledge Mgr. Dana Knajflova for text proofreading and
   linguistics. The study was supported by Charles University, Faculty of
   Medicine in Hradec Kralove, the Czech Republic, by projects Q40-09,
   Q40-10, Q40-11, and SVV-260397/2017.
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NR 66
TC 15
Z9 15
U1 0
U2 5
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2314-8861
EI 2314-7156
J9 J IMMUNOL RES
JI J Immunol. Res.
PD MAY 20
PY 2020
VL 2020
AR 7352637
DI 10.1155/2020/7352637
PG 9
WC Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology
GA LU7SJ
UT WOS:000537950300001
PM 32537470
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Topel, ML
   Kelli, HM
   Lewis, TT
   Dunbar, SB
   Vaccarino, V
   Taylor, HA
   Quyyumi, AA
AF Topel, Matthew L.
   Kelli, Heval M.
   Lewis, Tene T.
   Dunbar, Sandra B.
   Vaccarino, Viola
   Taylor, Herman A.
   Quyyumi, Arshed A.
TI High neighborhood incarceration rate is associated with cardiometabolic
   disease in nonincarcerated black individuals
SO ANNALS OF EPIDEMIOLOGY
LA English
DT Article
DE Mass incarceration; Cardiovascular health; Racial disparities
ID MASS INCARCERATION; STRESS; HEALTH; RISK
AB Purpose: To examine the association between residence in neighborhoods with high rates of incarceration and cardiometabolic disease among nonincarcerated individuals.
   Methods: We used data from two community cohort studies (n = 1368) in Atlanta, Georgia - META-Health and Predictive Health (2005-2012)-to assess the association between neighborhood incarceration rate and cardiometabolic disease, adjusting for individual-level and neighborhood-level factors. We also examined the interaction between race and neighborhood incarceration rate.
   Results: Individuals living in neighborhoods with high incarceration rates were more likely to have dyslipidemia (odds ratio [OR] = 1.47; 95% confidence interval [CI] = 1.03-2.09) and metabolic syndrome (OR = 1.67; 95% CI = 1.07-2.59) in fully adjusted models. Interactions between race and neighborhood incarceration rate were significant; black individuals living in neighborhoods with high incarceration rates were more likely to have hypertension (OR = 1.59; 95% CI = 1.01 2.49), dyslipidemia (OR = 1.77; 95% CI = 1.12-2.80), and metabolic syndrome (OR = 1.80; 95% CI = 1.09-2.99).
   Conclusions: Black individuals living in neighborhoods with high rates of incarceration have worse cardiometabolic health profiles. Criminal justice reform may help reduce race-specific health disparities in the United States. (C) 2018 Elsevier Inc. All rights reserved.
C1 [Topel, Matthew L.; Kelli, Heval M.; Quyyumi, Arshed A.] Emory Univ, Sch Med, Div Cardiol, Dept Med, 1462 Clifton Rd NE,Suite 507, Atlanta, GA 30322 USA.
   [Lewis, Tene T.; Vaccarino, Viola] Emory Univ, Dept Epidemiol, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA.
   [Dunbar, Sandra B.; Taylor, Herman A.] Emory Univ, Nell Hodgson Woodruff Sch Nursing, Atlanta, GA 30322 USA.
   [Taylor, Herman A.] Morehouse Sch Med, Dept Med, Cardiovasc Res Inst, Atlanta, GA 30310 USA.
C3 Emory University; Emory University; Rollins School Public Health; Emory
   University; Morehouse School of Medicine
RP Quyyumi, AA (corresponding author), Emory Univ, Sch Med, Div Cardiol, Dept Med, 1462 Clifton Rd NE,Suite 507, Atlanta, GA 30322 USA.
EM aquyyum@emory.edu
RI Vaccarino, Viola/AAW-5600-2020; Lewis, Tene/JBS-7332-2023
OI Vaccarino, Laura Viola/0000-0002-9054-0654
FU National Institutes of Health [UL1 RR025008, U01 HL079156-01, T32
   HL130025-02]; American Heart Association Strategically Focused Research
   Network on Disparities [0000031288]
FX This research was supported by grants from the National Institutes of
   Health (UL1 RR025008, U01 HL079156-01, T32 HL130025-02) and the American
   Heart Association Strategically Focused Research Network on Disparities
   (Grant 0000031288).
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NR 20
TC 29
Z9 32
U1 0
U2 5
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1047-2797
EI 1873-2585
J9 ANN EPIDEMIOL
JI Ann. Epidemiol.
PD JUL
PY 2018
VL 28
IS 7
BP 489
EP 492
DI 10.1016/j.annepidem.2018.01.011
PG 4
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA GJ3VN
UT WOS:000435227000011
PM 29433977
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Fabbri, LM
   Luppi, F
   Beghé, B
   Rabe, KF
AF Fabbri, L. M.
   Luppi, F.
   Beghe, B.
   Rabe, K. F.
TI Complex chronic comorbidities of COPD
SO EUROPEAN RESPIRATORY JOURNAL
LA English
DT Review
DE bronchitis; chronic diseases; chronic heart failure; emphysema;
   inflammation; metabolic syndrome
ID OBSTRUCTIVE PULMONARY-DISEASE; NECROSIS-FACTOR-ALPHA; COMMUNITY-ACQUIRED
   PNEUMONIA; AIR-FLOW OBSTRUCTION; OXIDATIVE STRESS; LUNG-FUNCTION;
   CARDIOVASCULAR-DISEASE; SYSTEMIC INFLAMMATION; HEART-FAILURE;
   RISK-FACTORS
AB Chronic obstructive pulmonary disease (COPD) is defined by fixed airflow limitation associated with an abnormal pulmonary and systemic inflammatory response of the lungs to cigarette smoke.
   The systemic inflammation induced by smoking may also cause chronic heart failure, metabolic syndrome and other chronic diseases, which may contribute to the clinical manifestations and natural history of COPD. Thus COPD can no longer be considered a disease only of the lungs, as it is often associated with a wide variety of systemic consequences.
   A better understanding of the origin and consequences of systemic inflammation, and of potential therapies, will most likely lead to better care of patients with COPD. Medical textbooks and clinical guidelines still largely ignore the fact that COPD seldom occurs in isolation.
   As the diagnosis and assessment of severity of COPD may be greatly affected by the presence of comorbid conditions, the current authors believe that lung function measurement, noninvasive assessment of cardiovascular and metabolic functions, and circulating inflammatory markers (e.g. C-reactive protein) might help to better characterise these patients. Similarly, preventive and therapeutic interventions should address the patient in their complexity.
C1 [Fabbri, L. M.; Luppi, F.; Beghe, B.] Univ Modena & Reggio Emilla, Dept Oncol Haematol & Res Dis, I-41100 Modena, Italy.
   [Rabe, K. F.] Leiden Univ, Med Ctr, Dept Pulm, NL-2300 RA Leiden, Netherlands.
C3 Universita di Modena e Reggio Emilia; Leiden University; Leiden
   University Medical Center (LUMC); Leiden University - Excl LUMC
RP Fabbri, LM (corresponding author), Univ Modena & Reggio Emilla, Dept Oncol Haematol & Res Dis, Via Pozzo 71, I-41100 Modena, Italy.
EM fabbri.leonardo@unimore.it
RI Akdis, Cezmi/AAV-4844-2020; Rabe, Klaus/AAW-6296-2021; Luppi,
   Fabrizio/AAG-8099-2019; Fabbri, Leonardo/I-4055-2012
OI Akdis, Cezmi/0000-0001-8020-019X; LUPPI, FABRIZIO/0000-0001-5775-5947;
   Rabe, Klaus F./0000-0002-7020-1401; Fabbri, Leonardo/0000-0001-8894-1689
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NR 133
TC 481
Z9 508
U1 0
U2 35
PU EUROPEAN RESPIRATORY SOC JOURNALS LTD
PI SHEFFIELD
PA 442 GLOSSOP RD, SHEFFIELD S10 2PX, ENGLAND
SN 0903-1936
EI 1399-3003
J9 EUR RESPIR J
JI Eur. Resp. J.
PD JAN
PY 2008
VL 31
IS 1
BP 204
EP 212
DI 10.1183/09031936.00114307
PG 9
WC Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Respiratory System
GA 251RG
UT WOS:000252390800027
PM 18166598
DA 2025-06-11
ER

PT J
AU Tigno, XT
   Ding, SY
   Erwin, JM
   Aslam, S
   Hansen, BC
AF Tigno, Xenia T.
   Ding, Shi Ying
   Erwin, Joseph M.
   Aslam, Sadaf
   Hansen, Barbara C.
TI Understanding type 2 diabetes and aging: lessons from nonhuman primates
SO ASIAN BIOMEDICINE
LA English
DT Review
DE aging; diabetes; metabolic syndrome; obesity; nonhuman primates; rhesus
   macaques
ID AGE-RELATED-CHANGES; RHESUS-MONKEYS; INSULIN-RESISTANCE; METABOLIC
   SYNDROME; STRESS; HYPERINSULINEMIA; RESTRICTION; HYPERTROPHY; PARAMETERS
AB Background: The increase in global prevalence of obesity and diabetes, and the growth of the elderly population worldwide emphasize the biomedical research need for an animal model which exhibits close similarity to human disease and aging processes. The rhesus monkey develops obesity and type 2 diabetes spontaneously and naturally when ad libitum fed, within a lifespan which is about a third that of the human.
   Objective: To characterize the genetic, structural, biochemical and physiological changes occurring in monkeys who age successfully and in those who develop obesity and type 2 diabetes.
   Results: The rhesus monkey demonstrates the same signs and symptoms of type 2 diabetes, including macro- and microvascular complications, as observed in humans. Age-related changes, potential biomarkers, and proposed biochemical pathways of aging can be readily investigated, with outcomes very similar to those in humans.
   Conclusion: The rhesus monkey model imparts valuable insights to normal and pathological processes accompanying aging and type 2 diabetes. It also provides a valuable tool by which to test novel therapeutic interventions which otherwise can not be performed in humans due to ethical considerations, but where results are highly translatable.
C1 [Tigno, Xenia T.; Aslam, Sadaf; Hansen, Barbara C.] Univ S Florida, Coll Med, Tampa, FL 33612 USA.
   [Ding, Shi Ying] Univ Maryland, Sch Med, Baltimore, MD 21201 USA.
   [Erwin, Joseph M.] Virginia Polytech Inst & State Univ, Virginia Maryland Reg Coll Vet Med, Blacksburg, VA 24060 USA.
C3 State University System of Florida; University of South Florida;
   University System of Maryland; University of Maryland Baltimore;
   Virginia Polytechnic Institute & State University
RP Tigno, XT (corresponding author), Univ S Florida, Coll Med, Tampa, FL 33612 USA.
EM xtigno@yahoo.com
RI Hansen, Barbara/J-8723-2012
CR [Anonymous], GLOBAL BURDEN DIABET
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NR 44
TC 2
Z9 2
U1 0
U2 2
PU WALTER DE GRUYTER GMBH
PI BERLIN
PA GENTHINER STRASSE 13, D-10785 BERLIN, GERMANY
SN 1905-7415
EI 1875-855X
J9 ASIAN BIOMED
JI Asian Biomed.
PD DEC
PY 2007
VL 1
IS 4
BP 359
EP 376
PG 18
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 318UQ
UT WOS:000257118700003
DA 2025-06-11
ER

PT J
AU Eriksson, MD
   Eriksson, JG
   Kautiainen, H
   Salonen, MK
   Mikkola, TM
   Kajantie, E
   Wasenius, N
   von Bonsdorff, M
   Korhonen, P
   Laine, MK
AF Eriksson, Mia D.
   Eriksson, Johan G.
   Kautiainen, Hannu
   Salonen, Minna K.
   Mikkola, Tuija M.
   Kajantie, Eero
   Wasenius, Niko
   von Bonsdorff, Mikaela
   Korhonen, Paivi
   Laine, Merja K.
TI Higher carotid-radial pulse wave velocity is associated with
   non-melancholic depressive symptoms in men - findings from Helsinki
   Birth Cohort Study
SO ANNALS OF MEDICINE
LA English
DT Article
DE Cohort study; comorbidity; depression; depressive disorder; pulse wave
   velocity
ID SMALL-VESSEL DISEASE; MIDDLE-AGED MEN; ARTERIAL STIFFNESS; ENDOTHELIAL
   DYSFUNCTION; VASCULAR DEPRESSION; METABOLIC SYNDROME; AORTIC STIFFNESS;
   BLOOD-PRESSURE; POPULATION; RISK
AB Background
   Depression and cardiovascular disease (CVD) are major causes of global disease burden that are interrelated through mostly unknown mechanisms. We studied the relationship of melancholic and non-melancholic depressive symptoms with arterial stiffness, an important underlying mechanism of CVD.
   Methods
   The Helsinki Birth Cohort Study recruited 683 previously extensively phenotyped subjects for this sub-study. Cross-sectional data along with responses regarding depressive symptoms were obtained for each participant. For evaluation of depressive symptoms, the Beck Depression Inventory (BDI)and subscales were used to measure melancholic and non-melancholic depressive symptoms. Arterial stiffness was assessed as pulse wave velocity (PWV) that was measured between the carotid and radial artery, and carotid and femoral artery.
   Results
   Of the participants, 532 scored <10 on the BDI and were classified as not having depressive symptoms. Of the 151 participants that scored >= 10 on the BDI, 122 were classified as having non-melancholic depressive symptoms and 29 as having melancholic depressive symptoms. Men had higher carotid-radial PWV (crPWV) values than women (p < .001). A positive relationship between BDI scores and crPWV (p < .001) was found in men. We also found higher crPWV in men with non-melancholic depressive symptoms compared to all others. No such differences were found in women.
   Discussion
   Arterial stiffness has a relationship with depressive symptoms and subtypes of depressive symptoms, at least in men. There is a significant relationship between higher PWV and non-melancholic depressive symptoms in men. Due to the intricate nature of the disease causality or directionality is impossible to infer solely based on this study. Further studies into the subtypes of depressive symptoms may be of benefit to understanding depression. KEY MESSAGES
   It is known that arterial stiffness contributes to cardiovascular disease, and is associated with depression.
   Higher Beck Depression Inventory scores are associated with higher carotid-radial pulse wave velocity in men.
   Non-melancholic depressive symptoms are associated with higher carotid-radial pulse wave velocity in men.
C1 [Eriksson, Mia D.] Helsinki Univ Hosp HUS, Primary Hlth Care Unit, Helsinki, Finland.
   [Eriksson, Johan G.; Kautiainen, Hannu; Salonen, Minna K.; Mikkola, Tuija M.; Wasenius, Niko; von Bonsdorff, Mikaela; Laine, Merja K.] Folkhalsan Res Ctr, Helsinki, Finland.
   [Eriksson, Johan G.; Wasenius, Niko; Laine, Merja K.] Univ Helsinki, Dept Gen Practice & Primary Hlth Care, Helsinki, Finland.
   [Eriksson, Johan G.; Wasenius, Niko; Laine, Merja K.] Helsinki Univ Hosp, Helsinki, Finland.
   [Eriksson, Johan G.] Natl Univ Singapore, Dept Obstet & Gynecol, Singapore, Singapore.
   [Eriksson, Johan G.] Natl Univ Singapore, Human Potential Translat Res Programme Yong Loo L, Singapore, Singapore.
   [Eriksson, Johan G.] ASTAR, Singapore Inst Clin Sci SICS, Singapore, Singapore.
   [Kautiainen, Hannu] Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland.
   [Salonen, Minna K.] Finnish Inst Hlth & Welf, Publ Hlth Promot Unit, Dept Publ Hlth Solut, Helsinki, Finland.
   [Mikkola, Tuija M.] Univ Helsinki, Fac Med, Clinicum, Helsinki, Finland.
   [Kajantie, Eero] Oulu Univ Hosp, MRC Oulu, PEDEGO Res Unit, Oulu, Finland.
   [Kajantie, Eero] Univ Oulu, Oulu, Finland.
   [Kajantie, Eero] Norwegian Univ Sci & Technol, Dept Clin & Mol Med, Trondheim, Norway.
   [von Bonsdorff, Mikaela] Univ Jyvaskyla, Gerontol Res Ctr, Jyvaskyla, Finland.
   [von Bonsdorff, Mikaela] Univ Jyvaskyla, Fac Sport & Hlth Sci, Jyvaskyla, Finland.
   [Korhonen, Paivi] Turku Univ Hosp, Dept Gen Practice, Turku, Finland.
   [Korhonen, Paivi] Univ Turku, Turku, Finland.
C3 Folkhalsan Research Center; University of Helsinki; University of
   Helsinki; Helsinki University Central Hospital; National University of
   Singapore; National University of Singapore; Agency for Science
   Technology & Research (A*STAR); A*STAR - Singapore Institute for
   Clinical Sciences (SICS); University of Eastern Finland; University of
   Helsinki; University of Oulu; University of Oulu; Norwegian University
   of Science & Technology (NTNU); University of Jyvaskyla; University of
   Jyvaskyla; University of Turku; University of Turku
RP Laine, MK (corresponding author), Folkhalsan Res Ctr, Helsinki, Finland.; Laine, MK (corresponding author), Univ Helsinki, Dept Gen Practice & Primary Hlth Care, Helsinki, Finland.; Laine, MK (corresponding author), Helsinki Univ Hosp, Helsinki, Finland.
EM merja.k.laine@helsinki.fi
RI Gibbs, J. Raphael/A-3984-2010; Wasenius, Niko/AAE-8927-2020; von
   Bonsdorff, Mikaela/A-5218-2015; Mikkola, Tuija/L-2835-2014; /H-8100-2016
OI Eriksson, Johan/0000-0002-2516-2060; von Bonsdorff,
   Mikaela/0000-0001-8530-5230; Eriksson, Mia/0000-0001-8968-8304;
   Wasenius, Niko/0000-0002-9007-6660; Mikkola, Tuija/0000-0003-0885-2788;
   /0000-0002-1848-1514
FU Finska Lakaresallskapet; Finnish Special Governmental Subsidy for Health
   Sciences; Academy of Finland [126775, 127437, 129255, 129306, 129907,
   130326, 134791, 209072, 210595, 213225, 263924, 275074, 315690];
   Samfundet Folkhalsan; Liv och Halsa; EU FP7 [Developmental Origins of
   Healthy Aging (DORIAN)] [278603]; EU H2020PHC-2014-Dyna Health grant
   [633595]; EU Horizon 2020 Award [733206]; European Commission, Horizon
   2020 award [733280]; RECAP; Foundation for Cardiovascular Research;
   Foundation for Diabetes Research; Foundation for Paediatric Research;
   Novo Nordisk Foundation; Signe and Ane Gyllenberg Foundation; Academy of
   Finland (AKA) [209072, 210595, 275074, 213225] Funding Source: Academy
   of Finland (AKA)
FX The HBCS has been supported by grants from Finska Lakaresallskapet, the
   Finnish Special Governmental Subsidy for Health Sciences, Academy of
   Finland [126775, 127437, 129255, 129306, 129907, 130326, 134791, 209072,
   210595, 213225, 263924, 275074 and 315690], Samfundet Folkhalsan, Liv
   och Halsa, EU FP7 [Developmental Origins of Healthy Aging (DORIAN)]
   project number 278603, and EU H2020PHC-2014-Dyna Health grant [633595]
   and EU Horizon 2020 Award [733206]. LIFECYCLE (all for the Helsinki
   Birth Cohort Study), European Commission, Horizon 2020 award [733280].
   RECAP, Foundation for Cardiovascular Research, Foundation for Diabetes
   Research, Foundation for Paediatric Research, Novo Nordisk Foundation,
   Signe and Ane Gyllenberg Foundation.
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NR 65
TC 7
Z9 7
U1 0
U2 2
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0785-3890
EI 1365-2060
J9 ANN MED
JI Ann. Med.
PD JAN 1
PY 2021
VL 53
IS 1
BP 531
EP 540
DI 10.1080/07853890.2021.1904277
PG 10
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA RD0VC
UT WOS:000633206100001
PM 33769182
OA Green Published
DA 2025-06-11
ER

PT J
AU Ayoub, HM
   McDonald, MR
   Sullivan, JA
   Tsao, R
   Meckling, KA
AF Ayoub, Hala M.
   McDonald, Mary Ruth
   Sullivan, James Alan
   Tsao, Rong
   Meckling, Kelly A.
TI Proteomic Profiles of Adipose and Liver Tissues from an Animal Model of
   Metabolic Syndrome Fed Purple Vegetables
SO NUTRIENTS
LA English
DT Article
DE obesity; hypertension; insulin resistance; high fat diet; carrots;
   potatoes; proteomic analyses
ID HIGH-FAT-DIET; BILE-ACID SYNTHESIS; ATP-CITRATE LYASE; FED RAT MODEL;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; AMELIORATES HYPERGLYCEMIA;
   CHOLESTEROL EFFLUX; LIPID DROPLETS; TART CHERRY
AB Metabolic Syndrome (MetS) is a complex disorder that predisposes an individual to Cardiovascular Diseases and type 2 Diabetes Mellitus. Proteomics and bioinformatics have proven to be an effective tool to study complex diseases and mechanisms of action of nutrients. We previously showed that substitution of the majority of carbohydrate in a high fat diet by purple potatoes (PP) or purple carrots (PC) improved insulin sensitivity and hypertension in an animal model of MetS (obese Zucker rats) compared to a control sucrose-rich diet. In the current study, we used TMT 10plex mass tag combined with LC-MS/MS technique to study proteomic modulation in the liver (n = 3 samples/diet) and adipose tissue (n = 3 samples/diet) of high fat diet-fed rats with or without substituting sucrose for purple vegetables, followed by functional enrichment analysis, in an attempt to elucidate potential molecular mechanisms responsible for the phenotypic changes seen with purple vegetable feeding. Protein folding, lipid metabolism and cholesterol efflux were identified as the main modulated biological themes in adipose tissue, whereas lipid metabolism, carbohydrate metabolism and oxidative stress were the main modulated themes in liver. We propose that enhanced protein folding, increased cholesterol efflux and higher free fatty acid (FFA) re-esterification are mechanisms by which PP and PC positively modulate MetS pathologies in adipose tissue, whereas, decreased de novo lipogenesis, oxidative stress and FFA uptake, are responsible for the beneficial effects in liver. In conclusion, we provide molecular evidence for the reported metabolic health benefits of purple carrots and potatoes and validate that these vegetables are good choices to replace other simple carbohydrate sources for better metabolic health.
C1 [Ayoub, Hala M.; Meckling, Kelly A.] Univ Guelph, Dept Human Hlth & Nutr Sci, Guelph, ON N1G 2W1, Canada.
   [McDonald, Mary Ruth; Sullivan, James Alan] Univ Guelph, Dept Plant Agr, Guelph, ON N1G 2W1, Canada.
   [Tsao, Rong] Agr & Agri Food Canada, Guelph Res & Dev Ctr, Guelph, ON N1G 5C9, Canada.
C3 University of Guelph; University of Guelph; Agriculture & Agri Food
   Canada
RP Meckling, KA (corresponding author), Univ Guelph, Dept Human Hlth & Nutr Sci, Guelph, ON N1G 2W1, Canada.
EM hayoub@uoguelph.ca; mrmcdona@uoguelph.ca; asulliva@uoguelph.ca;
   Rong.Cao@agr.gc.ca; kmecklin@uoguelph.ca
RI Tsao, Rong/I-3096-2014; McDonald, Mary Ruth/R-8809-2019
OI McDonald, Mary Ruth/0000-0002-2881-815X
FU Ontario Ministry of Agriculture, Food and Rural Affairs (OMAFRA);
   OMAFRA-U of G Highly Qualified Personnel (HQP) Scholarship
FX This work was funded by Ontario Ministry of Agriculture, Food and Rural
   Affairs (OMAFRA). H.A. was supported by OMAFRA-U of G Highly Qualified
   Personnel (HQP) Scholarship.
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NR 75
TC 9
Z9 9
U1 1
U2 9
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 2072-6643
J9 NUTRIENTS
JI Nutrients
PD APR
PY 2018
VL 10
IS 4
AR 456
DI 10.3390/nu10040456
PG 29
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA GJ3HN
UT WOS:000435182900072
PM 29642414
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Stanimirovic, J
   Radovanovic, J
   Banjac, K
   Obradovic, M
   Essack, M
   Zafirovic, S
   Gluvic, Z
   Gojobori, T
   Isenovic, ER
AF Stanimirovic, Julijana
   Radovanovic, Jelena
   Banjac, Katarina
   Obradovic, Milan
   Essack, Magbubah
   Zafirovic, Sonja
   Gluvic, Zoran
   Gojobori, Takashi
   Isenovic, Esma R.
TI Role of C-Reactive Protein in Diabetic Inflammation
SO MEDIATORS OF INFLAMMATION
LA English
DT Review
ID ACUTE-PHASE PROTEINS; INNATE IMMUNE-SYSTEM; INSULIN-RESISTANCE;
   OXIDATIVE STRESS; ADIPOSE-TISSUE; COMPLEMENT ACTIVATION; GUT MICROBIOTA;
   TNF-ALPHA; METABOLIC SYNDROME; OBESE-PATIENTS
AB Even though type 2 diabetes mellitus (T2DM) represents a worldwide chronic health issue that affects about 462 million people, specific underlying determinants of insulin resistance (IR) and impaired insulin secretion are still unknown. There is growing evidence that chronic subclinical inflammation is a triggering factor in the origin of T2DM. Increased C-reactive protein (CRP) levels have been linked to excess body weight since adipocytes produce tumor necrosis factor alpha (TNF-alpha) and interleukin 6 (IL-6), which are pivotal factors for CRP stimulation. Furthermore, it is known that hepatocytes produce relatively low rates of CRP in physiological conditions compared to T2DM patients, in which elevated levels of inflammatory markers are reported, including CRP. CRP also participates in endothelial dysfunction, the production of vasodilators, and vascular remodeling, and increased CRP level is closely associated with vascular system pathology and metabolic syndrome. In addition, insulin-based therapies may alter CRP levels in T2DM. Therefore, determining and clarifying the underlying CRP mechanism of T2DM is imperative for novel preventive and diagnostic procedures. Overall, CRP is one of the possible targets for T2DM progression and understanding the connection between insulin and inflammation may be helpful in clinical treatment and prevention approaches.
C1 [Stanimirovic, Julijana; Radovanovic, Jelena; Banjac, Katarina; Obradovic, Milan; Zafirovic, Sonja; Isenovic, Esma R.] Univ Belgrade, VINCA Inst Nucl Sci, Natl Inst Republ Serbia, Dept Radiobiol & Mol Genet, Belgrade, Serbia.
   [Essack, Magbubah; Gojobori, Takashi] King Abdullah Univ Sci & Technol KAUST, Computat Biosci Res Ctr CBRC, Comp Elect & Math Sci & Engn CEMSE Div, Thuwal, Saudi Arabia.
   [Gluvic, Zoran] Univ Belgrade, Univ Clin Hosp Ctr Zemun Belgrade, Clinic Int Med, Sch Med, Belgrade, Serbia.
C3 University of Belgrade; King Abdullah University of Science &
   Technology; University of Belgrade
RP Stanimirovic, J (corresponding author), Univ Belgrade, VINCA Inst Nucl Sci, Natl Inst Republ Serbia, Dept Radiobiol & Mol Genet, Belgrade, Serbia.
EM julijana1008@gmail.com; jelenarad89@gmail.com;
   banjackatarina@hotmail.com; obradovicmilan@hotmail.com;
   magbubah.essack@kaust.edu.sa; sonjazafirovic@hotmail.com;
   zorangluvic@yahoo.com; takashi.gojobori@kaust.edu.sa; isenovic@yahoo.com
RI Radovanović, Jelena/AAD-6068-2021; Isenovic, Esma/D-3017-2009; Gluvic,
   Zoran/Q-5190-2019; Zafirovic, Sonja/HTM-2478-2023; Stanimirovic,
   Julijana/LPQ-7867-2024; Obradovic, Milan/AGN-1229-2022; Essack,
   Magbubah/G-5008-2013
OI Obradovic, Milan/0000-0002-4769-2652; Gluvic, Zoran/0000-0001-6371-6610;
   Radovanovic, Jelena/0000-0002-3005-7943; Zafirovic,
   Sonja/0000-0002-5486-0079; Isenovic, Esma/0000-0002-0012-2636; Banjac,
   Katarina/0000-0001-6100-3887; Essack, Magbubah/0000-0003-2709-5356
FU Ministry of Education, Science and Technological Development of the
   Republic of Serbia [451-03-9/2021-14/200017]; KAUST grant OSR [4129];
   KAUST Office of Sponsored Research (OSR) Award [FCC/1/1976-20-01]; King
   Abdullah University of Science and Technology (KAUST) Base Research Fund
   [BAS/1/1059-01-01]
FX This work was funded by the Ministry of Education, Science and
   Technological Development of the Republic of Serbia (Contract No.
   #451-03-9/2021-14/200017) and KAUST grant OSR#4129 (awarded to E.R.I.
   and V.B.B.), which also supported M.O. M.E. has been supported by the
   KAUST Office of Sponsored Research (OSR) Award no. FCC/1/1976-20-01, and
   TG by the King Abdullah University of Science and Technology (KAUST)
   Base Research Fund (BAS/1/1059-01-01).
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NR 199
TC 71
Z9 76
U1 0
U2 16
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 0962-9351
EI 1466-1861
J9 MEDIAT INFLAMM
JI Mediat. Inflamm.
PD MAY 17
PY 2022
VL 2022
AR 3706508
DI 10.1155/2022/3706508
PG 15
WC Cell Biology; Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Immunology
GA 1U0RG
UT WOS:000805127700001
PM 35620114
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Zugravu, CA
   Bohiltea, RE
   Salmen, T
   Pogurschi, E
   Otelea, MR
AF Zugravu, Corina-Aurelia
   Bohiltea, Roxana-Elena
   Salmen, Teodor
   Pogurschi, Elena
   Otelea, Marina Ruxandra
TI Antioxidants in Hops: Bioavailability, Health Effects and Perspectives
   for New Products
SO ANTIOXIDANTS
LA English
DT Review
DE hops; antioxidants; metabolic syndrome; bioavailability
ID HUMULUS-LUPULUS L.; OXIDATIVE STRESS; PRENYLATED FLAVONOIDS;
   LUNG-CANCER; PPAR-ALPHA; BEER HOPS; IN-VITRO; XANTHOHUMOL; EXTRACT;
   GLUCOSE
AB Hop plant (Humulus lupulus L.) has been used by humans for ages, presumably first as a herbal remedy, then in the manufacturing of different products, from which beer is the most largely consumed. Female hops cones have different useful chemical compounds, an important class being antioxidants, mainly polyphenols. This narrative review describes the main antioxidants in hops, their bioavailability and biological effects, and the results obtained by now in the primary and secondary prevention of several non-communicable diseases, such as the metabolic syndrome related diseases and oncology. This article presents in vitro and in vivo data in order to better understand what was accomplished in terms of knowledge and practice, and what needs to be clarified by additional studies, mainly regarding xantohumol and its derivates, as well as regarding the bitter acids of hops. The multiple protective effects found by different studies are hindered up to now by the low bioavailability of some of the main antioxidants in hops. However, there are new promising products with important health effects and perspectives of use as food supplements, in a market where consumers increasingly search for products originating directly from plants.
C1 [Zugravu, Corina-Aurelia] Carol Davila Univ Med & Pharm, Dept Hyg & Ecol, Bucharest 050463, Romania.
   [Bohiltea, Roxana-Elena] Carol Davila Univ Med & Pharm Bucharest, Dept Obstet & Gynecol, Bucharest 020021, Romania.
   [Salmen, Teodor] Prof Dr NC Paulescu Natl Inst Diabet, Dept Diabet Nutr & Metab Dis, Bucharest 030167, Romania.
   [Pogurschi, Elena] Univ Agron Sci & Vet Med Bucharest, Fac Anim Prod Engn & Management, 57 Marasti Blvd, Bucharest 011464, Romania.
   [Otelea, Marina Ruxandra] Carol Davila Univ Med & Pharm, Clin Dept 5, Bucharest 050463, Romania.
C3 Carol Davila University of Medicine & Pharmacy; Carol Davila University
   of Medicine & Pharmacy; University of Agronomic Science & Veterinary
   Medicine - Bucharest; Carol Davila University of Medicine & Pharmacy
RP Salmen, T (corresponding author), Prof Dr NC Paulescu Natl Inst Diabet, Dept Diabet Nutr & Metab Dis, Bucharest 030167, Romania.
EM corina.zugravu@umfcd.ro; roxana.bohiltea@umfcd.ro;
   teodor.salmen@gmail.com; elena.pogurschi@usamv.ro;
   marina.otelea@umfcd.ro
RI Otelea, Marina/N-4200-2016; Salmen, Teodor/ABG-2747-2021; Zugravu,
   Corina/AAX-3256-2020; Bohiltea, Roxana Elena/L-6144-2017; SALMEN,
   Teodor/ACM-9451-2022
OI Zugravu, Corina/0000-0002-3563-6987; Bohiltea, Roxana
   Elena/0000-0002-6381-7419; Otelea, Marina Ruxandra/0000-0002-0829-0562;
   SALMEN, Teodor/0000-0003-4548-7441
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NR 108
TC 26
Z9 26
U1 1
U2 37
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD FEB
PY 2022
VL 11
IS 2
AR 241
DI 10.3390/antiox11020241
PG 16
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA ZL7DS
UT WOS:000763834600001
PM 35204124
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Mari, A
   Abufaraj, M
   Mansy, K
   Sievert, KD
AF Mari, Andrea
   Abufaraj, Mohammad
   Mansy, Karim
   Sievert, Karl-Dietrich
TI Obesity and its implications on nononcological urological surgery
SO CURRENT OPINION IN UROLOGY
LA English
DT Review
DE incontinence; metabolic syndrome; nononcological urological surgery;
   obesity; outcomes and complications; urolithiasis
ID BODY-MASS INDEX; BENIGN PROSTATIC ENLARGEMENT; MIDURETHRAL SLING
   PROCEDURES; STRESS URINARY-INCONTINENCE; MID-URETHRAL SLINGS; LONG-TERM
   OUTCOMES; PERCUTANEOUS NEPHROLITHOTOMY; FLEXIBLE URETERORENOSCOPY;
   METABOLIC SYNDROME; RENAL STONES
AB Purpose of review
   To review and summarize the current literature of the implications of obesity on nononcological urological surgery. We conducted a comprehensive search of the current literature with emphasis on the published literature in the last 18 months.
   Recent findings
   Over time, obese patients have become a more common encounter in clinical practice. Obesity represents a considerable operative challenge and has been linked to a higher rate of postoperative complications. Data regarding surgery for incontinence are inconsistent. Nevertheless, the success rates in obese women are high, and complication rates are relatively low with comparable results to nonobese women. In renal surgery, percutaneous nephrolithotomy and minipercutaneous nephrolithotomy are feasible, well tolerated, and effective even in obese patients. However, certain precautions and availability of proper instruments are necessary.
   Summary
   Although randomized clinical data are lacking and the results of many studies are inconsistent, evidence supports the feasibility and safety of different nononcological urological interventions in obese patients. Moreover, the success rates and the overall complication rates seem to be comparable to nonobese patients with some exceptions.
C1 [Mari, Andrea; Abufaraj, Mohammad; Mansy, Karim; Sievert, Karl-Dietrich] Med Univ Vienna, Dept Urol, Vienna, Austria.
   [Abufaraj, Mohammad] Univ Jordan, Jordan Univ Hosp, Dept Special Surg, Div Urol, Amman, Jordan.
   [Sievert, Karl-Dietrich] Univ Med Ctr, Dept Urol, Rostock, Germany.
C3 Medical University of Vienna; University of Jordan; University of
   Rostock
RP Sievert, KD (corresponding author), Med Univ Vienna, Vienna Gen Hosp, Dept Urol, Wahringer Gurtel 18-20, A-1090 Vienna, Austria.
EM kd_sievert@hotmail.com
RI Mari, Andrea/N-7656-2019; Abufaraj, Mohammad/I-2336-2019; Mari,
   Andrea/H-8616-2017
OI Mari, Andrea/0000-0001-9070-5706; Abufaraj, Mohammad/0000-0002-6603-6319
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NR 68
TC 3
Z9 3
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0963-0643
EI 1473-6586
J9 CURR OPIN UROL
JI Curr. Opin. Urol.
PD SEP
PY 2017
VL 27
IS 5
BP 456
EP 463
DI 10.1097/MOU.0000000000000430
PG 8
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA FB9OR
UT WOS:000406469100009
PM 28650868
DA 2025-06-11
ER

PT J
AU Akanji, AO
   Ohaeri, JU
   Al-Shammri, SA
   Fatania, HR
AF Akanji, A. O.
   Ohaeri, J. U.
   Al-Shammri, S. A.
   Fatania, H. R.
TI Associations of blood homocysteine concentrations in Arab schizophrenic
   patients
SO CLINICAL BIOCHEMISTRY
LA English
DT Article
DE Arabs; schizophrenia; homocysteine; lipoproteins; oxidative stress;
   disease phenotypes
ID METHYLENETETRAHYDROFOLATE REDUCTASE POLYMORPHISM; PLASMA HOMOCYSTEINE;
   SERUM HOMOCYSTEINE; METABOLIC SYNDROME; RISK-FACTOR; FOLATE;
   HYPERHOMOCYSTEINEMIA; PREVALENCE; DEMENTIA; C677T
AB Background: This study aimed to evaluate the blood homocysteine concentration in Arab patients with schizophrenia and assess its associations with clinical phenotypes of the disease.
   Subjects and methods: Two age-matched groups of subjects were studied: (1) Healthy Controls, HC, n = 165; (2) patients with schizophrenia, SZ: n = 207. Each subject was evaluated with a standard questionnaire for age at disease onset, family history, disease severity and outcome. Plasma homocysteine levels (Hcys) were measured by immunoassay and serum levels of other biochemical parameters were measured by routine Autoanalyzer techniques.
   Results and discussion: Group HC was heavier (body mass index, BMI) while SZ bad greater waist-hip ratio (WHR) and plasma Hcys levels. In SZ, there were significant correlations between Heys and BMI, triglycerides and HDL. Heys levels in SZ were highest in the younger male patients.
   Conclusion: Schizophrenic patients have increased blood Hcys levels which correlate with components of the metabolic syndrome. Hcys levels were highest in the younger male patients and were not influenced by prognostic features of the disease. (c) 2007 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
C1 Kuwait Univ, Fac Med, Dept Pathol, Clin Chem Unit, Safat 13110, Kuwait.
   Kuwait Univ, Fac Med, Dept Med, Safat 13060, Kuwait.
   Kuwait Univ, Fac Med, Dept Biochem, Safat 13060, Kuwait.
C3 Kuwait University; Kuwait University; Kuwait University
RP Akanji, AO (corresponding author), Kuwait Univ, Fac Med, Dept Pathol, Clin Chem Unit, POB 24923, Safat 13110, Kuwait.
EM abayomi@hse.edu.kw
RI Akanji, Abayomi/AAY-4732-2021
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NR 53
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Z9 33
U1 0
U2 7
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0009-9120
EI 1873-2933
J9 CLIN BIOCHEM
JI Clin. Biochem.
PD SEP
PY 2007
VL 40
IS 13-14
BP 1026
EP 1031
DI 10.1016/j.clinbiochem.2007.06.001
PG 6
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA 209XV
UT WOS:000249422200018
PM 17601525
DA 2025-06-11
ER

PT J
AU de Souza, JA
   Vindis, C
   Hansel, B
   Négre-Salvayre, A
   Therond, P
   Serrano, CV
   Chantepie, S
   Salvayre, R
   Bruckert, E
   Chapman, MJ
   Kontush, A
AF de Souza, Juliana A.
   Vindis, Cecile
   Hansel, Boris
   Negre-Salvayre, Anne
   Therond, Patrice
   Serrano, Carlos V., Jr.
   Chantepie, Sandrine
   Salvayre, Robert
   Bruckert, Eric
   Chapman, M. John
   Kontush, Anatol
TI Metabolic syndrome features small, apolipoprotein A-I-poor,
   triglyceride-rich HDL3 particles with defective anti-apoptotic activity
SO ATHEROSCLEROSIS
LA English
DT Article
DE reactive oxygen species; annexin V; Sphingosine-1-phosphate;
   anti-apoptotic activity; antioxidative activity
ID HIGH-DENSITY-LIPOPROTEIN; ELEVATED OXIDATIVE STRESS; PREVENT CELL-DEATH;
   ENDOTHELIAL-CELLS; ANTIOXIDATIVE ACTIVITY; OXIDIZED LDL; SPHINGOSINE
   1-PHOSPHATE; CARDIOVASCULAR-DISEASE; CHOLESTEROL EFFLUX;
   INSULIN-RESISTANCE
AB The metabolic syndrome (MetS) phenotype is typically characterized by visceral obesity, insulin resistance, atherogenic dyslipidemia involving hypertriglyceridemia and subnormal levels of high density lipoprotein-cholesterol (HDL-C), oxidative stress and elevated cardiovascular risk. The potent antioxidative activity of small HDL3 is defective in MetS [Hansel B, et al. J Clin Endocrinol Metab 2004;89:4963-71]. We evaluated the functional capacity of small HDL3 particles from MetS subjects to protect endothelial cells from apoptosis induced by mildly oxidized low-density lipoprotein (oxLDL).
   MetS subjects presented an insulin-resistant obese phenotype, with hypertriglyceridemia, elevated apolipoprotein B and insulin levels, but subnormal HDL-C concentrations and chronic low grade inflammation (threefold elevation of C-reactive protein). When human microvascular endothelial cells (HMEC-1) were incubated with oxLDL (200 jig apolipoprotein B/ml) in the presence or absence of control HDL subfiractions (25 mu g protein/ml), small, dense HDL3b and 3c significantly inhibited cellular annexin V binding and intracellular generation of reactive oxygen species. The potent anti-apoptotic activity of small HDL3c particles was reduced (-35%; p < 0.05) in MetS subjects (n = 16) relative to normolipidemic controls (n = 7). The attenuated anti-apoptotic activity of HDL3c correlated with abdominal obesity, atherogenic dyslipidemia and systemic oxidative stress (p < 0.05), and was intimately associated with altered physicochemical properties of apolipoprotein A-I (apoA-I-poor HDL3c, involving core cholesteryl ester depletion and triglyceride enrichment.
   We conclude that in MetS, apoA-I-poor, small, dense HDL3c exert defective protection of endothelial cells from oxLDL-induced apoptosis, potentially reflecting functional anomalies intimately associated with abnormal neutral lipid core content. (c) 2007 Elsevier Ireland Ltd. All rights reserved.
C1 [de Souza, Juliana A.; Chantepie, Sandrine; Chapman, M. John; Kontush, Anatol] Univ Paris 06, F-75013 Paris, France.
   [de Souza, Juliana A.; Hansel, Boris; Chantepie, Sandrine; Bruckert, Eric; Chapman, M. John; Kontush, Anatol] Grp Hosp Pitie Salpetriere, AP HP, F-75013 Paris, France.
   [de Souza, Juliana A.; Hansel, Boris; Therond, Patrice; Chantepie, Sandrine; Chapman, M. John; Kontush, Anatol] INSERM, Dyalipopreteinemia & Anthrosclerosis Res Unit 551, F-75013 Paris, France.
   [de Souza, Juliana A.; Serrano, Carlos V., Jr.] Univ Sao Paulo, Inst Heart, Sao Paulo, Brazil.
   [Vindis, Cecile; Negre-Salvayre, Anne; Salvayre, Robert] CHU Rangueli, INSERM, Unit 466, Toulouse, France.
   [Therond, Patrice] Univ Paris 05, Dept Biochem, F-75005 Paris, France.
C3 Sorbonne Universite; Assistance Publique Hopitaux Paris (APHP); Hopital
   Universitaire Pitie-Salpetriere - APHP; Sorbonne Universite; Institut
   National de la Sante et de la Recherche Medicale (Inserm); Universidade
   de Sao Paulo; Institut National de la Sante et de la Recherche Medicale
   (Inserm); CHU de Toulouse; Universite Paris Cite
RP Kontush, A (corresponding author), Hop Pitie, INSERM, Uniye 551, Pavillon Benjamin,83 Blvd Hop, F-75651 Paris 13, France.
EM kontush@chupsjussieu.fr; kontush@chups.jussieu.fr
RI Serrano, Carlos/I-2729-2013; Vindis, Cécile/AAH-2708-2019; Kontush,
   Anatol/J-2198-2016; chapman, john/Y-2742-2019
OI Vindis, Cecile/0000-0003-2421-1155; Kontush, Anatol/0000-0002-9008-7335;
   CHANTEPIE-LABORDE, Sandrine/0000-0003-1652-432X; Negre-Salvayre,
   Anne/0000-0003-2136-5706
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NR 48
TC 99
Z9 108
U1 0
U2 6
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0021-9150
EI 1879-1484
J9 ATHEROSCLEROSIS
JI Atherosclerosis
PD MAR
PY 2008
VL 197
IS 1
BP 84
EP 94
DI 10.1016/j.atherosclerosis.2007.08.009
PG 11
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 282LS
UT WOS:000254569900010
PM 17868679
DA 2025-06-11
ER

PT J
AU Fresta, CG
   Fidilio, A
   Lazzarino, G
   Musso, N
   Grasso, M
   Merlo, S
   Amorini, AM
   Bucolo, C
   Tavazzi, B
   Lazzarino, G
   Lunte, SM
   Caraci, F
   Caruso, G
AF Fresta, Claudia G.
   Fidilio, Annamaria
   Lazzarino, Giacomo
   Musso, Nicolo
   Grasso, Margherita
   Merlo, Sara
   Amorini, Angela M.
   Bucolo, Claudio
   Tavazzi, Barbara
   Lazzarino, Giuseppe
   Lunte, Susan M.
   Caraci, Filippo
   Caruso, Giuseppe
TI Modulation of Pro-Oxidant and Pro-Inflammatory Activities of M1
   Macrophages by the Natural Dipeptide Carnosine
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE carnosine; M1 macrophages; nitric oxide; oxidative stress; inflammation;
   antioxidants; energy metabolism
ID NITRIC-OXIDE PRODUCTION; MICROCHIP ELECTROPHORESIS; COGNITIVE DEFICITS;
   OXIDATIVE STRESS; SUPEROXIDE-PRODUCTION; ALZHEIMERS-DISEASE; CELLS;
   TGF-BETA-1; INCREASES; MUSCLE
AB Carnosine is a natural endogenous dipeptide widely distributed in mammalian tissues, existing at particularly high concentrations in the muscles and brain and possesses well-characterized antioxidant and anti-inflammatory activities. In an in vitro model of macrophage activation, induced by lipopolysaccharide + interferon-gamma (LPS + IFN-gamma), we here report the ability of carnosine to modulate pro-oxidant and pro-inflammatory activities of macrophages, representing the primary cell type that is activated as a part of the immune response. An ample set of parameters aimed to evaluate cytotoxicity (MTT assay), energy metabolism (HPLC), gene expressions (high-throughput real-time PCR (qRT-PCR)), protein expressions (western blot) and nitric oxide production (qRT-PCR and HPLC), was used to assess the effects of carnosine on activated macrophages challenged with a non cytotoxic LPS (100 ng/mL) + IFN-gamma (600 U/mL) concentration. In our experimental model, main carnosine beneficial e ffects were: (1) the modulation of nitric oxide production and metabolism; (2) the amelioration of the macrophage energy state; (3) the decrease of the expressions of pro-oxidant enzymes (Nox-2, Cox-2) and of the lipid peroxidation product malondialdehyde; (4) the restoration and/or increase of the expressions of antioxidant enzymes (Gpx1, SOD-2 and Cat); (5) the increase of the transforming growth factor-beta 1 (TGF-beta 1) and the down-regulation of the expressions of interleukins 1 beta and 6 (IL-1 beta and IL-6) and 6) the increase of the expressions of Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) and heme oxygenase-1 (HO-1). According to these results carnosine is worth being tested in the treatment of diseases characterized by elevated levels of oxidative stress and inflammation (atherosclerosis, cancer, depression, metabolic syndrome, and neurodegenerative diseases).
C1 [Fresta, Claudia G.; Lunte, Susan M.] Univ Kansas, Ralph N Adams Inst Bioanalyt Chem, Lawrence, KS 66047 USA.
   [Fresta, Claudia G.; Lunte, Susan M.] Univ Kansas, Dept Pharmaceut Chem, Lawrence, KS 66047 USA.
   [Fidilio, Annamaria; Grasso, Margherita; Caraci, Filippo] Univ Catania, Dept Drug Sci, I-95125 Catania, Italy.
   [Lazzarino, Giacomo] UniCamillus St Camillus Int Univ Hlth Sci, I-00131 Rome, Italy.
   [Musso, Nicolo] Univ Catania, BRIT, I-95125 Catania, Italy.
   [Grasso, Margherita; Caraci, Filippo; Caruso, Giuseppe] IRCCS, Oasi Res Inst, I-94018 Troina, EN, Italy.
   [Merlo, Sara; Amorini, Angela M.; Bucolo, Claudio; Lazzarino, Giuseppe] Univ Catania, Dept Biomed & Biotechnol Sci, I-95125 Catania, Italy.
   [Tavazzi, Barbara] Univ Cattolica Sacro Cuore, Inst Biochem & Clin Biochem, I-00168 Rome, Italy.
   [Tavazzi, Barbara] Fdn Policlin Univ A Gemelli IRCCS, I-00168 Rome, Italy.
   [Lunte, Susan M.] Univ Kansas, Dept Chem, Lawrence, KS 66047 USA.
   [Fresta, Claudia G.] Univ Catania, Dept Biomed & Biotechnol Sci, PhD Program Neurosci, I-95125 Catania, Italy.
C3 University of Kansas; University of Kansas; University of Catania;
   University of Catania; IRCCS - Oasi Research Institute; University of
   Catania; Catholic University of the Sacred Heart; IRCCS Policlinico
   Gemelli; Catholic University of the Sacred Heart; IRCCS Policlinico
   Gemelli; University of Kansas; University of Catania
RP Caruso, G (corresponding author), IRCCS, Oasi Res Inst, I-94018 Troina, EN, Italy.; Lazzarino, G (corresponding author), Univ Catania, Dept Biomed & Biotechnol Sci, I-95125 Catania, Italy.
EM forclaudiafresta@gmail.com; afunict@gmail.com; lazzarig@unict.it;
   nmusso@unict.it; grassomargherita940@gmail.com; sara_merlo@hotmail.com;
   amorini@unict.it; claudio.bucolo@unict.it; barbara.tavazzi@unicatt.it;
   giacomo.lazzarino@unicamillus.org; slunte@ku.edu; carafil@hotmail.com;
   forgiuseppecaruso@gmail.com
RI MUSSO, Nicolo'/CAH-2950-2022; Lazzarino, Giacomo/IQT-0407-2023; Lunte,
   Susan/G-2263-2018; TAVAZZI, BARBARA/AAB-9830-2019; Merlo,
   Sara/X-3872-2019; Caruso, Giuseppe/C-1435-2018; lazzarino,
   giuseppe/K-2277-2015; Caraci, Filippo/K-2262-2016; Fidilio,
   Annamaria/GNP-1855-2022; Grasso, Margherita/AAB-6242-2019
OI Caruso, Giuseppe/0000-0003-1571-5327; lazzarino,
   giuseppe/0000-0002-5917-7279; Merlo, Sara/0000-0002-6558-9800; Caraci,
   Filippo/0000-0002-9867-6054; TAVAZZI, BARBARA/0000-0001-8743-0895;
   Fidilio, Annamaria/0000-0002-9279-0171; MUSSO,
   Nicolo'/0000-0003-2451-1158; Grasso, Margherita/0000-0003-4458-5226;
   Fresta, Claudia Giuseppina/0000-0002-8113-6457; AMORINI, Angela
   Maria/0000-0003-3525-9955; Lazzarino, Giacomo/0000-0003-1639-0966
FU American Heart Association (Midwest Affiliate Postdoctoral Research
   Fellowship) [NFP0075515]; Italian Ministry of Health Research Program
   [RC: 2635256]
FX GC received support from the American Heart Association (Midwest
   Affiliate Postdoctoral Research Fellowship), grant number NFP0075515.
   G.C. and F.C. would like to acknowledge the support received from the
   Italian Ministry of Health Research Program 2018, grant number RC:
   2635256.
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NR 92
TC 75
Z9 76
U1 0
U2 22
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD FEB
PY 2020
VL 21
IS 3
AR 776
DI 10.3390/ijms21030776
PG 22
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA KY4PQ
UT WOS:000522551601045
PM 31991717
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Wang, XY
   Zhang, HP
   Zhang, PF
   Hao, SL
   Yang, X
   Zhou, X
AF Wang, Xiangyu
   Zhang, Huaping
   Zhang, Pengfu
   Hao, Shulan
   Yang, Xi
   Zhou, Xin
TI Clinical investigation of lipopolysaccharide in the persistence of
   metabolic syndrome (MS) through the activation of GRP78-IRE1α-ASK1
   signaling pathway
SO MOLECULAR AND CELLULAR BIOCHEMISTRY
LA English
DT Article
DE Lipopolysaccharide (LPS); Endoplasmic reticulum (ER) stress;
   Inflammation; Insulin resistance
ID ENDOPLASMIC-RETICULUM STRESS; INSULIN-RESISTANCE; GUT MICROBIOTA;
   INFLAMMATION; OBESITY; PATHOGENESIS
AB Objective Endoplasmic reticulum stress (ERS) might play a pivotal role in the persistence of metabolic syndrome (MS). Lipopolysaccharide (LPS) derived from various gram-negative bacteria could result in the ERS. Therefore, we aimed to investigate the association between LPS and ERS in MS. Method We enrolled 86 patients with MS and 42 healthy people aged 35-65 years. Body weight, waist circumference, blood pressure were measured. LPS, LBP and inflammation factors, fasting plasma glucose (FPG), insulin, total cholesterol (TC), triglyceride, high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), free fatty acid (FFA) were analyzed in blood plasma of patient's cohort. Body mass index (BMI) and HOMA-IR were calculated. The mRNA and protein expression of ERS GRP78, IRE1 alpha, ASK1 and IKK beta, JNK1 were measured in blood plasma of patient's cohort by RT-PCR and Elisa. MS was defined by the updated National Cholesterol Education Program Adult Treatment Panel III criterion for Asian Americans. Results BMI, waist circumference, blood pressure, FPG, insulin, HOMA-IR, TC, triglyceride, HDL-C, LDL-C, FFA and LPS, LBP, TNF-alpha, CRP, IL-1, IL-6, MCP-1 were significantly higher in patients with MS than healthy people (P < 0.001). The correlation analysis suggested that LPS were associated with TNF-alpha, IL-1, IL-6, MCP-1, LBP, FFA, HOMA-IR potently (P < 0.05). The marker gene and protein expressions of ERS (GRP78, IRE1 alpha, ASK1, IKK beta and JNK) were significantly overexpressed in patients with MS and were positive correlation with LPS (P < 0.05). Conclusion LPS may play an important role in mediating chronic low-grade inflammation by activating the ERS GRP78-IRE1 alpha-ASK1 signaling pathway, contributing to the persistence of MS.
C1 [Yang, Xi] Shanxi Prov Res Inst Tradit Chinese Med, Dept Oncol, Taiyuan 030012, Peoples R China.
   [Zhang, Huaping; Zhou, Xin] Shanxi Med Univ, Dept Pathophysiol, Basic Med Sci, 52 Xin Jian South Rd, Taiyuan 030001, Peoples R China.
   [Wang, Xiangyu; Zhang, Pengfu; Hao, Shulan] Shanxi Med Univ, Shanxi Prov Key Lab Oral Dis Prevent & New Mat, Sch & Hosp Stomatol, Taiyuan 030001, Peoples R China.
C3 Shanxi Medical University; Shanxi Medical University
RP Yang, X (corresponding author), Shanxi Prov Res Inst Tradit Chinese Med, Dept Oncol, Taiyuan 030012, Peoples R China.; Zhou, X (corresponding author), Shanxi Med Univ, Dept Pathophysiol, Basic Med Sci, 52 Xin Jian South Rd, Taiyuan 030001, Peoples R China.
EM Susieyx0824@126.com; xinxin6633@yeah.net
RI zhang, huaping/KQU-3923-2024
FU Natural Science Foundation of Shanxi Province, China [201801D221387,
   201901D111196]; Shanxi Scholarship Council of China [2020-074]; 2020
   Shanxi Province Graduate Education Reform (mandatory) research project
   China [2020YJJG135]; Follow-up to the Fourth National Oral Health
   Epidemiological Survey [201502002]; Chinese Stomatological Association,
   China
FX This study was funded by the Natural Science Foundation of Shanxi
   Province, China [No. 201801D221387], the Natural Science Foundation of
   Shanxi Province, China [No. 201901D111196], Shanxi Scholarship Council
   of China [No. 2020-074] and 2020 Shanxi Province Graduate Education
   Reform (mandatory) research project China [No. 2020YJJG135], Follow-up
   to the Fourth National Oral Health Epidemiological Survey [No.
   201502002], Chinese Stomatological Association, China.
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NR 39
TC 1
Z9 1
U1 0
U2 3
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0300-8177
EI 1573-4919
J9 MOL CELL BIOCHEM
JI Mol. Cell. Biochem.
PD FEB
PY 2022
VL 477
IS 2
BP 585
EP 592
DI 10.1007/s11010-021-04302-2
EA NOV 2021
PG 8
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA YQ3NZ
UT WOS:000723988200002
PM 34850317
DA 2025-06-11
ER

PT J
AU Radice, RP
   Limongi, AR
   Viviano, E
   Padula, MC
   Martelli, G
   Bermano, G
AF Radice, Rosa Paola
   Limongi, Antonina Rita
   Viviano, Emanuele
   Padula, Maria Carmela
   Martelli, Giuseppe
   Bermano, Giovanna
TI Effects of astaxanthin in animal models of obesity-associated diseases:
   A systematic review and meta-analysis
SO FREE RADICAL BIOLOGY AND MEDICINE
LA English
DT Review
DE Astaxanthin; Meta-analysis; Metabolic syndrome; Non-alcoholic fatty
   liver disease; Obesity; Type 2 diabetes
ID DIET-INDUCED OBESITY; LOWERS BLOOD-PRESSURE; OXIDATIVE STRESS;
   HAEMATOCOCCUS-PLUVIALIS; ADIPOSE-TISSUE; ENDOPLASMIC-RETICULUM; INSULIN
   SENSITIVITY; PPAR-GAMMA; INFLAMMATION; MICE
AB Background and aim: Obesity is a major risk factor for several diseases, including metabolic syndrome (MetS), non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes (T2D). The use of natural products, such as astaxanthin (ASX), a potent antioxidant compound produced by the freshwater green microalga Haematococcus pluvialis, has gained particular interest to reduce oxidative stress and inflammation, and to improve redox status, often associated with obesity. A systematic review and meta-analysis was performed to comprehensively examine the effects of ASX in animal models of diet induced obesity-associated diseases in order to inform the design of future human clinical studies for ASX use as supplement or nutraceutical.
   Methods: Cinahl, Cochraine, MEDLINE, Scopus and Web of Science were searched for English-language manuscripts published between January 2000 and April 2020 using the following key words: astaxanthin, obesity, non-alcoholic fatty liver disease, diabetes mellitus type 2, NAFLD and metabolic.
   Results: Seventeen eligible articles, corresponding to 21 animal studies, were included in the final quantitative analysis. ASX, at different concentrations and administered for different length of time, induced a significant reduction in adipose tissue weight (P = 0.05) and systolic blood pressure (P < 0.0001) in control animals. In animal models of T2D, ASX significantly reduced serum glucose levels (P = 0.04); whereas it improved several disease biomarkers in the blood (e.g. cholesterol, triglycerides, ALT and AST, P < 0.10), and reduced liver (P = 0.0002) and body weight (P = 0.11), in animal models of NAFLD.
   Conclusions: Supplementation of ASX in the diet has positive effects on symptoms associated with obesity related diseases in animals, by having lipid-lowering, hypo-insulin and hypoglycaemic capacity, protecting organs from oxidative stress and mitigating the immune system, as suggested in this review.
C1 [Radice, Rosa Paola; Limongi, Antonina Rita; Viviano, Emanuele; Padula, Maria Carmela; Martelli, Giuseppe] Univ Basilicata, Dept Sci, Potenza, Italy.
   [Radice, Rosa Paola; Limongi, Antonina Rita] Bioinnova Srls, Via Ponte Nove Luci, Potenza, Italy.
   [Padula, Maria Carmela] San Carlo Hosp Potenza, Rheumatol Inst Lucania IReL, Rheumatol Dept Lucania, Potenza, Italy.
   [Padula, Maria Carmela] Madonna delle Grazie Hosp Matera, Potenza, Italy.
   [Bermano, Giovanna] Robert Gordon Univ, Sch Pharm & Life Sci, Ctr Obes Res & Educ CORE, Sir Ian Wood Bldg,Garthdee Rd, Aberdeen AB10 7GJ, Scotland.
C3 Italfarmaco; University of Basilicata; Robert Gordon University
RP Bermano, G (corresponding author), Robert Gordon Univ, Sch Pharm & Life Sci, Ctr Obes Res & Educ CORE, Sir Ian Wood Bldg,Garthdee Rd, Aberdeen AB10 7GJ, Scotland.
EM g.bermano@rgu.ac.uk
RI Limongi, Antonina Rita/AAZ-9422-2021; Radice, Rosa Paola/AFJ-7984-2022;
   Viviano, Emanuele/IST-7926-2023; Padula, Maria/S-8285-2019
OI Viviano, Emanuele/0000-0001-8264-5205; Radice, Rosa
   Paola/0000-0002-5043-8313; , Antonina Rita Limongi/0000-0003-1570-8370;
   Bermano, Giovanna/0000-0001-6027-6437
FU University of Basilicata
FX RPR was supported by a fellowship under the Erasmus Traineeship Program
   from the University of Basilicata during her stay in Aberdeen.
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NR 64
TC 21
Z9 23
U1 4
U2 28
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0891-5849
EI 1873-4596
J9 FREE RADICAL BIO MED
JI Free Radic. Biol. Med.
PD AUG 1
PY 2021
VL 171
BP 156
EP 168
DI 10.1016/j.freeradbiomed.2021.05.008
EA MAY 2021
PG 13
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA SV2VS
UT WOS:000663682800001
PM 33974978
OA Green Published, Green Accepted
DA 2025-06-11
ER

PT J
AU Park, YM
   Lee, HJ
   Kang, SG
   Choi, JE
   Cho, JH
   Kim, L
AF Park, Young-Min
   Lee, Heon-Jeong
   Kang, Seung-Gul
   Choi, Jung-Eun
   Cho, Jae-Hyuck
   Kim, Leen
TI Lack of Association between Glutathione S-Transferase-M1,-T1, and-P1
   Polymorphisms and Olanzapine-Induced Weight Gain in Korean Schizophrenic
   Patients
SO PSYCHIATRY INVESTIGATION
LA English
DT Article
DE Weight gain; Olanzapine; Polymorphism; Glutathione-S-transferase
ID MULTIFACTOR-DIMENSIONALITY REDUCTION; GENE-GENE INTERACTIONS;
   QUALITY-OF-LIFE; INSULIN-RESISTANCE; ANTIPSYCHOTIC MEDICATIONS; ATYPICAL
   ANTIPSYCHOTICS; MULTIPLE-SCLEROSIS; TARDIVE-DYSKINESIA; METABOLIC
   SYNDROME; OXIDATIVE STRESS
AB Objective Oxidative stress may be an important pathogenic mechanism in the obesity and metabolic syndrome. The aims of this study was to assess the possible association between the oxidative stress related Glutathione S-Transferase genes (GST-M1, GST-T1, and GST-P1) variants and the olanzapine-induced weight gain in Korean schizophrenic patients.
   Methods We categorized 78 schizophrenic patients into two groups the more than 7% weight gain from baseline (weight gain >= 7%) and the less weight gain (weight gain <7%) groups according to weight change between before and after long-term olanzapine treatment (440 +/- 288 days). All participants were genotyped for the GST-M1, GST-T1 and GST-P1 genes. Differences in allele frequencies between cohorts with different body weight changes were evaluated by a chi-square analysis and Fisher's exact test. The multifactor dimensionality reduction (MDR) approach was used to analyze gene-gene interactions.
   Results Mean body weight gain was 5.42 kg. There was no difference in the null genotype distribution of GST-M1 and -T1 between subjects with body weight gain >= 7% compared to subjects with body weight gain <7% (p>0.05). No significant difference in GST-P1 genotype and allele frequencies were observed between the groups (p>0.05). MDR analysis did not show a significant interaction between the three GST gene variants and susceptibility to weight gain (p>0.05).
   Conclusion These findings do not support a relationship between the genetic variants of three GST genes (GST-M1, -T1 and -P1) and weight gain in Korean schizophrenic patients receiving olanzapine treatment. Psychiatry Investig 2010;7:147-152
C1 [Lee, Heon-Jeong; Kang, Seung-Gul; Choi, Jung-Eun; Kim, Leen] Korea Univ, Coll Med, Dept Psychiat, Seoul 136705, South Korea.
   [Park, Young-Min; Cho, Jae-Hyuck] Inje Univ, Coll Med, Ilsan Paik Hosp, Dept Neuropsychiat, Goyang, South Korea.
   [Lee, Heon-Jeong; Choi, Jung-Eun] Korea Univ, Coll Med, Div Brain Korea Biomed Sci 21, Seoul 136705, South Korea.
C3 Korea University; Korea University Medicine (KU Medicine); Inje
   University; Korea University; Korea University Medicine (KU Medicine)
RP Lee, HJ (corresponding author), Korea Univ, Coll Med, Dept Psychiat, 126-1 Anam Dong 5 Ga, Seoul 136705, South Korea.
EM leehjeong@korea.ac.kr
RI ; Lee, Heon-Jeong/K-5871-2015
OI Kang, Seung-Gul/0000-0003-4933-0433; Lee, Heon-Jeong/0000-0002-9560-2383
FU Korean Government [KRF-2008-313-E00333]; Inje University
FX This work was supported by the Korea Research Foundation Grant funded by
   the Korean Government (KRF-2008-313-E00333). PYM was supported by a 2008
   Inje University research grant.
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NR 44
TC 5
Z9 6
U1 0
U2 2
PU KOREAN NEUROPSYCHIATRIC ASSOC
PI SEOUL
PA RN 522, G-FIVE CENTRAL PLAZA 1685-8 SEOCHO 4-DONG, SEOCHO-GU, SEOUL,
   137-882, SOUTH KOREA
SN 1738-3684
EI 1976-3026
J9 PSYCHIAT INVEST
JI Psychiatry Investig.
PD JUN
PY 2010
VL 7
IS 2
BP 147
EP 152
DI 10.4306/pi.2010.7.2.147
PG 6
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychiatry
GA 614PN
UT WOS:000279072300011
PM 20577625
OA Green Published, hybrid, Green Submitted
DA 2025-06-11
ER

PT J
AU Abraham, SB
   Rubino, D
   Sinaii, N
   Ramsey, S
   Nieman, LK
AF Abraham, S. B.
   Rubino, D.
   Sinaii, N.
   Ramsey, S.
   Nieman, L. K.
TI Cortisol, Obesity, and the Metabolic Syndrome: A Cross-Sectional Study
   of Obese Subjects and Review of the Literature
SO OBESITY
LA English
DT Review
ID PITUITARY-ADRENAL AXIS; BODY-FAT DISTRIBUTION; PLASMA-CORTISOL;
   CARDIOVASCULAR RISK; INSULIN-RESISTANCE; PRODUCTION-RATES;
   BLOOD-PRESSURE; HEART-DISEASE; WOMEN; MEN
AB Objective: Circulating cortisol and psychosocial stress may contribute to the pathogenesis of obesity and metabolic syndrome (MS). To evaluate these relationships, a cross-sectional study of 369 overweight and obese subjects and 60 healthy volunteers was performed and reviewed the previous literature.
   Design and Methods: Overweight and obese subjects had at least two other features of Cushing's syndrome. They underwent measurements representing cortisol dynamics (24 h urine cortisol excretion (UFC), bedtime salivary cortisol, 1 mg dexamethasone suppression test) and metabolic parameters (BMI, blood pressure (BP); fasting serum triglycerides, HDL, insulin, and glucose). Subjects also completed the Perceived Stress Scale (PSS). UFC, salivary cortisol, and weight from 60 healthy volunteers were analyzed.
   Results: No subject had Cushing's syndrome. UFC and dexamethasone responses were not associated with BMI or weight. However, salivary cortisol showed a trend to increase as BMI increased (P < 0.0001), and correlated with waist circumference (WC) in men (r(s) = 0.28, P = 0.02) and systolic BP in women (r(s) = 0.24, P = 0.0008). Post-dexamethasone cortisol levels were weak to moderately correlated with fasting insulin (r(s) = -0.31, P = 0.01) and HOMA-IR (r(s) = -0.31, P = 0.01) in men and systolic (r(s) = 0.18, P = 0.02) and diastolic BP (r(s) = 0.20, P = 0.009) in women. PSS results were higher in obese subjects than controls, but were not associated with cortisol or metabolic parameters. As expected, WC correlated with fasting insulin, HOMA-IR, and systolic BP (adjusted for BMI and gender; P < 0.01). Literature showed inconsistent relationships between cortisol and metabolic parameters.
   Conclusion: Taken together, these data do not support a strong relationship between systemic cortisol or stress and obesity or MS.
C1 [Abraham, S. B.; Nieman, L. K.] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Program Reprod & Adult Endocrinol, NIH, Bethesda, MD USA.
   [Rubino, D.; Ramsey, S.] Washington Ctr Weight Management & Res, Arlington, VA USA.
   [Rubino, D.; Ramsey, S.] George Washington Univ, Weight Management Program, Washington, DC USA.
   [Sinaii, N.] NIH, Biostat & Clin Epidemiol Serv, Ctr Clin, Bethesda, MD 20892 USA.
C3 National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver
   National Institute of Child Health & Human Development (NICHD); George
   Washington University; National Institutes of Health (NIH) - USA; NIH
   Clinical Center (CC)
RP Rubino, D (corresponding author), Washington Ctr Weight Management & Res, Arlington, VA USA.
EM drubino@wtmgmt.com
OI Rubino, Domenica/0000-0002-3072-2819; Nieman,
   Lynnette/0000-0003-0534-8025
FU Eunice Kennedy Shriver National Institute of Child Health and Human
   Development, National Institutes of Health
FX This work was supported in part by the intramural program of The Eunice
   Kennedy Shriver National Institute of Child Health and Human
   Development, National Institutes of Health.
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NR 40
TC 155
Z9 171
U1 1
U2 35
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1930-7381
EI 1930-739X
J9 OBESITY
JI Obesity
PD JAN
PY 2013
VL 21
IS 1
BP E105
EP E117
DI 10.1002/oby.20083
PG 13
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 187AE
UT WOS:000322086900015
PM 23505190
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Shen, J
   Lai, CQ
   Mattei, J
   Ordovas, JM
   Tucker, KL
AF Shen, Jian
   Lai, Chao-Qiang
   Mattei, Josiemer
   Ordovas, Jose M.
   Tucker, Katherine L.
TI Association of vitamin B-6 status with inflammation, oxidative stress,
   and chronic inflammatory conditions: the Boston Puerto Rican Health
   Study
SO AMERICAN JOURNAL OF CLINICAL NUTRITION
LA English
DT Article
ID C-REACTIVE PROTEIN; NUTRITION EXAMINATION SURVEY; HISPANIC WHITE ELDERS;
   PYRIDOXAL 5'-PHOSPHATE; MYOCARDIAL-INFARCTION; METABOLIC SYNDROME;
   CARIBBEAN ORIGIN; NATIONAL-HEALTH; DEFICIENT RATS; ACUTE-PHASE
AB Background: Low vitamin B-6 status has been linked to an increased risk of cardiovascular diseases. The cardioprotective effects of vitamin B-6 independent of homocysteine suggest that additional mechanisms may be involved.
   Objective: Our objective was to examine the cross-sectional association of vitamin B-6 status with markers of inflammation and oxidative stress.
   Design: We measured plasma pyridoxal-5'-phosphate (PLP), C-reactive protein (CRP), and ail oxidative DNA damage marker, urinary 8-hydroxydeoxyguanosine (8-OHdG), in Puerto Rican adults who were living in Massachusetts (n = 1205, aged 45-75 y).
   Results: There was a strong dose-response relation of plasma PLP concentration with plasma CRP. Increasing quartiles of PLP were significantly associated with lower CRP concentrations (geometric means: 4.7, 3.6, 3.1, and 2.5 mg/L; P for trend < 0.0001) and with lower urinary 8-OHdG concentrations (geometric means: 124, 124, 117, and 108 ng/mg creatinine; P for trend: 0.025) after multivariate adjustment. These negative associations persisted after plasma homocysteine was controlled for. Plasma PLP concentrations were significantly correlated with plasma fasting glucose (r = -0.1, P = 0.0006), glycated hemoglobin (r = -0.08, P = 0.006), and homeostasis model assessment of beta cell function (r = 0.082, P = 0.005). Metabolic syndrome, obesity, and diabetes were also significantly associated with low plasma PLP concentrations (P = 0.011, 0.0007, and 0.004, respectively).
   Conclusions: Low vitamin B-6 concentrations are associated with inflammation. higher oxidative stress, and metabolic conditions in older Puerto Rican adults. Our data suggest that vitamin B-6 may influence cardiovascular disease risk through mechanisms other than homocysteine and support the notion that nutritional status may influence the health disparities present in this population. Am J Clin Nutr 2010;91:337-42.
C1 [Shen, Jian; Lai, Chao-Qiang; Mattei, Josiemer; Ordovas, Jose M.; Tucker, Katherine L.] Tufts Univ, Human Nutr Res Ctr Aging, Jean Mayer USDA, Boston, MA 02111 USA.
   [Tucker, Katherine L.] Northeastern Univ, Bouve Coll Hlth Sci, Boston, MA 02115 USA.
C3 United States Department of Agriculture (USDA); Tufts University;
   Northeastern University
RP Shen, J (corresponding author), Tufts Univ, Human Nutr Res Ctr Aging, Jean Mayer USDA, 711 Washington St, Boston, MA 02111 USA.
EM jian.shen@tufts.edu
RI Tucker, Katherine/A-4545-2010; Ordovas, Jose/B-8727-2013; Mattei,
   Josiemer/H-1800-2016
OI Tucker, Katherine/0000-0001-7640-662X; Lai,
   Chao-Qiang/0000-0003-1107-8375; Ordovas, Jose/0000-0002-7581-5680;
   Mattei, Josiemer/0000-0001-5424-8245
FU National Institutes of Health, National Institute on Aging
   [01AG023394-02]; National Heart, Lung, and Blood Institute [HL54776]; US
   Department of Agriculture, Agricultural Research Service [53-K06-5-10,
   58-1950-9-001]
FX Supported by the National Institutes of Health, National Institute on
   Aging grant 01AG023394-02 and National Heart, Lung, and Blood Institute
   grant HL54776; and the US Department of Agriculture, Agricultural
   Research Service contracts 53-K06-5-10 and 58-1950-9-001.
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NR 50
TC 110
Z9 121
U1 0
U2 9
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0002-9165
EI 1938-3207
J9 AM J CLIN NUTR
JI Am. J. Clin. Nutr.
PD FEB
PY 2010
VL 91
IS 2
BP 337
EP 342
DI 10.3945/ajcn.2009.28571
PG 6
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 548GG
UT WOS:000273947500007
PM 19955400
OA Green Published
DA 2025-06-11
ER

PT J
AU Cadeddu, C
   Nocco, S
   Deidda, M
   Pau, F
   Colonna, P
   Mercuro, G
AF Cadeddu, Christian
   Nocco, Silvio
   Deidda, Martino
   Pau, Fabio
   Colonna, Paolo
   Mercuro, Giuseppe
TI Altered Transmural Contractility in Postmenopausal Women Affected by
   Cardiac Syndrome X
SO JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY
LA English
DT Article
DE Cardiac syndrome X; Exercise echocardiography; Speckle-tracking
   echocardiography
ID NORMAL CORONARY ARTERIOGRAMS; LEFT-VENTRICULAR FUNCTION;
   ANGINA-PECTORIS; CHEST-PAIN; ECHOCARDIOGRAPHY; EXERCISE; PERFUSION;
   RESERVE; STRESS; OBSTRUCTION
AB Background: Cardiac syndrome X (CSX) is characterized by typical angina and abnormal exercise test results, with normal coronary arteries. Cardiovascular magnetic resonance imaging has shown subendocardial hypoperfusion in patients with CSX after adenosine. The aim of this study was to investigate the contribution of separate myocardial layers to global function under stress in women with CSX.
   Methods: Twenty-two postmenopausal women with CSX were studied and compared with 20 healthy women matched for age and body mass index. All subjects underwent clinical evaluations and exercise echocardiography. Left ventricular systolic and diastolic parameters were evaluated at rest and at peak exercise. Layer-specific global longitudinal strain (GLS) and strain rate (SR) were assessed from the endocardium, midmyocardium, and epicardium using two-dimensional speckle-tracking echocardiography.
   Results: All subjects showed normal contractile function at rest and at peak exercise. Significant increases in GLS and SR in all myocardial layers were observed at peak exercise in the control group, whereas patients with CSX showed significantly lower increases in endocardial GLS and SR compared with the control group (endocardial Delta SR, 0.17 +/- 0.19 vs 0.33 +/- 0.13 [P < .01]; endocardial Delta GLS, 1.33 +/- 2.93 vs 6.64 +/- 2.62 [P < .001]). Moreover, significantly impaired diastolic function (Delta E', 1.1 +/- 3.3 vs 4.0 +/- 2.03) was observed in patients with CSX.
   Conclusions: The results of this study show subendocardial impairment of contractile function during exercise in patients with CSX, confirming the existence of reduced myocardial perfusion reserve in patients with CSX and suggesting layer-targeted exercise echocardiography as a sensitive diagnostic tool in the assessment of suspected CSX.
C1 [Cadeddu, Christian; Nocco, Silvio; Deidda, Martino; Pau, Fabio; Mercuro, Giuseppe] Univ Cagliari, Dept Med Sci, Monserrato, Italy.
   [Colonna, Paolo] Policlin Hosp, Dept Cardiol, Bari, Italy.
C3 University of Cagliari
RP Cadeddu, C (corresponding author), Univ Hosp Cagliari, Dept Med Sci, Str Statale 554,Km 4-500, I-09042 Cagliari, Italy.
EM cadedduc@unica.it
RI Colonna, Paolo/N-8144-2016; Cadeddu, Christian/AAI-9219-2020; Deidda,
   Martino/V-4453-2019; Deidda, Martino/L-3166-2015
OI Cadeddu, Christian/0000-0002-2823-1797; Deidda,
   Martino/0000-0002-3725-7614; mercuro, giuseppe/0000-0003-0097-2152;
   Colonna, Paolo/0000-0001-5864-2012
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NR 27
TC 17
Z9 18
U1 0
U2 4
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0894-7317
J9 J AM SOC ECHOCARDIOG
JI J. Am. Soc. Echocardiogr.
PD FEB
PY 2014
VL 27
IS 2
BP 208
EP 214
DI 10.1016/j.echo.2013.09.014
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 296WZ
UT WOS:000330217400011
PM 24161482
DA 2025-06-11
ER

PT J
AU Palachai, N
   Wattanathorn, J
   Muchimapura, S
   Thukham-mee, W
AF Palachai, Nut
   Wattanathorn, Jintanaporn
   Muchimapura, Supaporn
   Thukham-mee, Wipawee
TI Phytosome Loading the Combined Extract of Mulberry Fruit and Ginger
   Protects against Cerebral Ischemia in Metabolic Syndrome Rats
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Article
ID PPAR-GAMMA; OXIDATIVE STRESS; STROKE; HEALTH; ASSOCIATION; COMPONENTS;
   AGONISTS; RISK
AB The prevalence of ischemic stroke in metabolic syndrome (MetS) is continually increasing and produces a great impact on both qualities of life and annual healthcare budget. Due to the efficiency limitation of the current therapeutic strategy, the poor availability of polyphenol substances induced by the first pass effect and the beneficial effects of mulberry fruit and ginger on brain and MetS-related diseases together with the synergistic concept, the neuroprotective effect against ischemic stroke in MetS condition of phytosome containing the combined extract of mulberry fruit and ginger (PMG) has been considered. To explore the neuroprotective effect and possible underlying mechanism of PMG on brain damage in cerebral ischemic rat with MetS, male Wistar rats were induced MetS by high-carbohydrate high-fat diet (HCHF) for 16 weeks and subjected to the cerebral ischemia/reperfusion injury (CIRI) at the right middle cerebral artery (Rt. MCAO). PMG at doses of 50, 100, and 200 mg/kg were orally fed with for 21 days, and they were assessed brain damage, neurological deficit score, and the changes of oxidative stress markers, inflammatory markers, PPAR gamma expression, and epigenetic modification via DNMT-1 were performed. All doses of PMG significantly improved brain infarction, brain edema, and neurological deficit score. In addition, the reduction in DNMT-1, MDA level, NF-kappa B, TNF alpha, and C-reactive protein together with the increase in SOD, CAT, and GPH-Px activities, and PPAR gamma expression in the lesion brain were also observed. The current data clearly revealed the neuroprotective effect against cerebral ischemia with MetS condition. The possible underlying mechanism might occur partly via the suppression of DNMT-1 giving rise to the improvement of signal transduction via PPAR gamma resulting in the decreasing of inflammation and oxidative stress. In conclusion, PMG is the potential neuroprotectant candidate against ischemic stroke in the MetS condition. However, the clinical trial is still essential.
C1 [Palachai, Nut] Khon Kaen Univ, Dept Physiol, Khon Kaen 40002, Thailand.
   [Palachai, Nut] Khon Kaen Univ, Grad Sch, Neurosci Program, Fac Med, Khon Kaen 40002, Thailand.
   [Palachai, Nut; Wattanathorn, Jintanaporn; Muchimapura, Supaporn; Thukham-mee, Wipawee] Khon Kaen Univ, Res Inst Human High Performance & Hlth Promot, Integrat Complementary Alternat Med Res & Dev Ctr, Khon Kaen 40002, Thailand.
   [Wattanathorn, Jintanaporn; Muchimapura, Supaporn; Thukham-mee, Wipawee] Khon Kaen Univ, Fac Med, Dept Physiol, Khon Kaen 40002, Thailand.
C3 Khon Kaen University; Khon Kaen University; Khon Kaen University; Khon
   Kaen University
RP Wattanathorn, J (corresponding author), Khon Kaen Univ, Res Inst Human High Performance & Hlth Promot, Integrat Complementary Alternat Med Res & Dev Ctr, Khon Kaen 40002, Thailand.; Wattanathorn, J (corresponding author), Khon Kaen Univ, Fac Med, Dept Physiol, Khon Kaen 40002, Thailand.
EM jinwat05@gmail.com
RI Palachai, Nut/HKM-6781-2023
OI Palachai, Nut/0000-0002-9672-9941; Wattanathorn,
   Jintanaporn/0000-0002-7383-2348; Muchimapura,
   Supaporn/0000-0001-7756-1955; Thukhammee, Wipawee/0000-0001-6923-396X
FU Royal Golden Jubilee (RGJ) Ph.D. is a part of Thailand Research Fund
   (TRF) [PHD/0181/2558]; Integrative Complementary Alternative Medicine
   Research and Development Center in Research Institute for Human High
   Performance and Health Promotion, Khon Kaen University, Khon Kaen,
   Thailand
FX This study was supported by The Royal Golden Jubilee (RGJ) Ph.D. which
   is a part of Thailand Research Fund (TRF). (Research No. PHD/0181/2558)
   and the Integrative Complementary Alternative Medicine Research and
   Development Center in Research Institute for Human High Performance and
   Health Promotion, Khon Kaen University, Khon Kaen, Thailand.
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NR 37
TC 19
Z9 22
U1 0
U2 11
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PD JUL 25
PY 2020
VL 2020
AR 5305437
DI 10.1155/2020/5305437
PG 15
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA MZ4ZH
UT WOS:000559133200001
PM 32774678
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Mustieles, V
   Arrebola, JP
AF Mustieles, Vicente
   Arrebola, Juan P.
TI How polluted is your fat? What the study of adipose tissue can
   contribute to environmental epidemiology
SO JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH
LA English
DT Article
ID PERSISTENT ORGANIC POLLUTANTS; OXIDATIVE STRESS; ADULT COHORT; ENDOCRINE
   DISRUPTORS; METABOLIC SYNDROME; EXPOSURE; ASSOCIATIONS; HEALTH; OBESITY;
   CANCER
AB The study of the potential contribution of low-dose exposure to environmental chemicals on the development of chronic conditions in human populations is often hampered by methodological issues, including exposure misclassification and the inability to assess biological effects in target organs. White adipose tissue (WAT) presents the unique feature of being both an advantageous matrix for assessing long-term exposure to mixtures of persistent organic pollutants and an interesting tissue to investigate early preclinical effects. Moreover, other lipophilic non-persistent chemicals and heavy metals have been recently quantified in fat, suggesting that human WAT contains chemical mixtures more complex than initially thought. However, WAT has been scarcely used in environmental epidemiology due to collection difficulties. In this essay we discuss the potential of using human WAT as a source of both exposure and effect biomarkers, with the aim of advancing the epidemiological research of obesity-related diseases, including metabolic syndrome and cancer. Overall, we discuss the implications of investigating WAT in a multidisciplinary framework combining toxicological and epidemiological knowledge in order to improve the inference of causal relationships in observational settings. We finalise by suggesting feasible designs and scenarios in which WAT samples may be reasonably collected.
C1 [Mustieles, Vicente] Univ Granada, Ctr Biomed Res CIBM, Granada, Spain.
   [Mustieles, Vicente; Arrebola, Juan P.] CIBER Epidemiol & Publ Hlth CIBERESP, Madrid, Spain.
   [Mustieles, Vicente; Arrebola, Juan P.] Inst Invest Biosanitaria Ibs GRANADA, Granada, Spain.
   [Arrebola, Juan P.] Univ Granada, Dept Prevent Med & Publ Hlth, Granada 18071, Spain.
C3 University of Granada; CIBER - Centro de Investigacion Biomedica en Red;
   CIBERESP; Instituto de Investigacion Biosanitaria IBS Granada;
   University of Granada
RP Arrebola, JP (corresponding author), Univ Granada, Dept Prevent Med & Publ Hlth, Granada 18071, Spain.
EM jparrebola@ugr.es
RI Mustieles, Vicente/KAM-1750-2024; Arrebola, Juan/A-5205-2017
OI Mustieles, Vicente/0000-0002-2010-5438; Arrebola, Juan
   P./0000-0002-8643-2423
FU Ramon y Cajal program (Ministerio de Economia, Industria y
   Competitividad, Spain) [RYC-2016-20155]; Human Biomonitoring for Europe
   Project (European Union Commission) [H2020-EJP-HBM4EU]; Instituto de
   Salud Carlos III [FIS-PI16/01858]
FX JPA is under contract within Ramon y Cajal program (RYC-2016-20155,
   Ministerio de Economia, Industria y Competitividad, Spain). VM is under
   contract within the Human Biomonitoring for Europe Project (European
   Union Commission H2020-EJP-HBM4EU). The authors acknowledge the funding
   received from Instituto de Salud Carlos III (FIS-PI16/01858).
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NR 64
TC 34
Z9 37
U1 0
U2 8
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 0143-005X
EI 1470-2738
J9 J EPIDEMIOL COMMUN H
JI J. Epidemiol. Community Health
PD MAY
PY 2020
VL 74
IS 5
BP 401
EP 407
DI 10.1136/jech-2019-213181
PG 7
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA NM6LJ
UT WOS:000568206800001
PM 32019765
DA 2025-06-11
ER

PT J
AU Bahadoran, Z
   Mirmiran, P
   Jeddi, S
   Carlström, M
   Azizi, F
   Ghasemi, A
AF Bahadoran, Zahra
   Mirmiran, Parvin
   Jeddi, Sajad
   Carlstrom, Mattias
   Azizi, Fereidoun
   Ghasemi, Asghar
TI Circulating markers of nitric oxide homeostasis and cardiometabolic
   diseases: insights from population-based studies
SO FREE RADICAL RESEARCH
LA English
DT Review
DE Cardiovascular disease; chronic kidney disease; hypertension; metabolic
   syndrome; nitrate; nitric oxide; nitrite; type 2 diabetes
ID CHRONIC KIDNEY-DISEASE; INSULIN-RESISTANCE; DIETARY NITRATE;
   CARDIOVASCULAR-DISEASE; OXIDATIVE STRESS; BLOOD-PRESSURE; METABOLITES
   NITRITE; GENDER-DIFFERENCES; CIGARETTE-SMOKING; ADIPOSE-TISSUE
AB Emerging data suggest that impaired nitric oxide (NO) homeostasis has a key role in development of cardiometabolic disorders. The association between circulating levels of NO metabolites, i.e. nitrate and nitrite (NOx), and risk of chronic diseases has not yet been fully clarified. This work aims to address epidemiologic aspects of NO metabolism and discusses different physiologic and pathophysiologic conditions influencing circulating NOx. Further, cross-sectional associations of serum NOx with metabolic disorders are described and along the way, potential short-term and long-term power of serum NOx for predicting cardiometabolic outcomes are reviewed. Results from population-based studies show that circulating NOx is affected by aging, smoking habits, pregnancy, menopause status, thyroid hormones, and various pathologic conditions including type 2 diabetes, insulin resistance, hypertension, and renal dysfunction. Lifestyle factors, especially dietary habits, but also smoking habits and the degree of physical activity influence NO homeostasis and the circulating levels of NOx. Elevated serum NOx, due to increased iNOS activity, is associated with increased incidence of metabolic syndrome, different obesity phenotypes, and cardiovascular events.
C1 [Bahadoran, Zahra] Shahid Beheshti Univ Med Sci, Nutr & Endocrine Res Ctr, Res Inst Endocrine Sci, Tehran, Iran.
   [Mirmiran, Parvin] Shahid Beheshti Univ Med Sci, Natl Nutr & Food Technol Res Inst, Fac Nutr Sci & Food Technol, Dept Clin Nutr & Diet Therapy, Tehran, Iran.
   [Jeddi, Sajad; Ghasemi, Asghar] Shahid Beheshti Univ Med Sci, Endocrine Physiol Res Ctr, Res Inst Endocrine Sci, Tehran, Iran.
   [Carlstrom, Mattias] Karolinska Inst, Dept Physiol & Pharmacol, Stockholm, Sweden.
   [Azizi, Fereidoun] Shahid Beheshti Univ Med Sci, Endocrine Res Ctr, Res Inst Endocrine Sci, Tehran, Iran.
C3 Shahid Beheshti University Medical Sciences; Shahid Beheshti University
   Medical Sciences; Shahid Beheshti University Medical Sciences;
   Karolinska Institutet; Shahid Beheshti University Medical Sciences
RP Ghasemi, A (corresponding author), 24 Sahid Erabi St,Yemen St,Chamran Exp, Tehran, Iran.
EM ghasemi@endocrine.ac.ir
RI Bahadoran, Zahra/V-2003-2019; Jeddi, Sajad/U-8493-2019; Mirmiran,
   Parvin/V-1433-2019; Azizi, Fereidoun/ABD-4136-2021; Carlstrom,
   Mattias/E-7350-2015; Ghasemi, Asghar/O-4145-2017
OI Azizi, Fereidoun/0000-0002-6470-2517; Carlstrom,
   Mattias/0000-0001-9923-8729; Mirmiran, Parvin/0000-0003-2391-4924;
   Ghasemi, Asghar/0000-0001-6867-2151; Jeddi, Sajad/0000-0002-3911-6620
FU Shahid Beheshti University of Medical Sciences [5-1396/D/101865]
FX This study was supported by Shahid Beheshti University of Medical
   Sciences (Grant no. 5-1396/D/101865).
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NR 188
TC 7
Z9 8
U1 0
U2 3
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1071-5762
EI 1029-2470
J9 FREE RADICAL RES
JI Free Radic. Res.
PD APR 3
PY 2019
VL 53
IS 4
BP 359
EP 376
DI 10.1080/10715762.2019.1587168
EA APR 2019
PG 18
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA IK9QD
UT WOS:000471420600001
PM 30821533
DA 2025-06-11
ER

PT J
AU Ouanes, S
   Castelao, E
   Gebreab, S
   von Gunten, A
   Preisig, M
   Popp, J
AF Ouanes, Sami
   Castelao, Enrique
   Gebreab, Sirak
   von Gunten, Armin
   Preisig, Martin
   Popp, Julius
TI Life events, salivary cortisol, and cognitive performance in nondemented
   subjects: a population-based study
SO NEUROBIOLOGY OF AGING
LA English
DT Article
DE Cognition; Life events; Cortisol; Memory; Dementia; Stress
ID CARDIOVASCULAR RISK-FACTORS; POSTTRAUMATIC-STRESS-DISORDER;
   ALZHEIMERS-DISEASE; OLDER-ADULTS; MEMORY PERFORMANCE; AWAKENING
   RESPONSE; METABOLIC SYNDROME; AMYLOID-BETA; DEMENTIA; DEPRESSION
AB Older people are particularly exposed to stressful events, known to activate the hypothalamus-pituitaryadrenal axis resulting in increased cortisol levels. High cortisol has been associated with deleterious effects on cognition. We hypothesized that stressful life events could increase cortisol secretion leading to cognitive impairment. A cross-sectional analysis was conducted using data from Colaus/PsyColaus, a longitudinal population-based study among Lausanne residents. Salivary cortisol samples were obtained from 796 nondemented subjects aged at least 65. A neuropsychological battery was used to assess cognitive performance and determine the Clinical Dementia Rating Sum of Boxes (CDRSOB). Lifetime life events and their subjective impact were assessed using a validated questionnaire. The total impact of life events was associated neither with cortisol area under the curve (AUC) nor with CDRSOB nor with any cognitive domain performance. The CDRSOB was associated with the cortisol AUC, controlling for age, sex, body mass index, education and depressive symptoms ( p = 0.003; B = 0.686 [ 0.240; 1.333]; r = 0.114). This association between CDRSOB and the cortisol AUC remained significant after controlling for life events total impact ( p = 0.040; B = 0.591 [ 0.027; 1.155]; r = 0.106). These findings do not support the hypothesis that stressful life events increase cortisol secretion leading to cognitive impairment. The association of higher cortisol levels with poorer cognition might be not a mere reflection of stressful events but rather explained by other factors, yet to be elucidated. (C) 2016 Elsevier Inc. All rights reserved.
C1 [Ouanes, Sami; Castelao, Enrique; Gebreab, Sirak; von Gunten, Armin; Preisig, Martin; Popp, Julius] Univ Lausanne Hosp, Dept Psychiat, Lausanne, Switzerland.
C3 University of Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV)
RP Popp, J (corresponding author), Univ Lausanne Hosp, Dept Psychiat, Old Age Psychiat, Route Mt, CH-1008 Prilly, Switzerland.
EM julius.popp@chuv.ch
RI Preisig, Martin/H-3441-2016; Popp, Julius/IWM-3913-2023; Popp,
   Julius/ADG-7439-2022
OI Popp, Julius/0000-0002-0068-0312; Preisig, Martin/0000-0001-5689-4259;
   Ouanes, Sami/0000-0003-0867-060X; GEBREAB, SIRAK
   ZENEBE/0000-0001-5849-075X; Castelao, Enrique/0000-0003-1966-3683; von
   Gunten, Armin/0000-0001-7852-3803
FU GlaxoSmithKline; Faculty of Biology and Medicine of Lausanne; Swiss
   National Research Foundation [3200B0-105993, 3200B0-118308,
   33CSCO-122661, 33CS30139468, 33CS30-148401, 320030_141179];
   GlaxoSmithKline, the Faculty of Biology and Medicine of Lausanne; Swiss
   National Science Foundation (SNF) [33CS30_148401] Funding Source: Swiss
   National Science Foundation (SNF)
FX The authors would like to express their gratitude to the Lausanne
   inhabitants who volunteered to participate in the PsyCoLaus study. The
   authors would also like to thank all the investigators of the CoLaus
   study, which made the psychiatric PsyCoLaus study possible. The
   CoLaus/PsyCoLaus study was and is supported by research grants from
   GlaxoSmithKline, the Faculty of Biology and Medicine of Lausanne, and
   the Swiss National Research Foundation (grants 3200B0-105993,
   3200B0-118308, 33CSCO-122661, 33CS30139468 and 33CS30-148401). Julius
   Popp received support from the Swiss National Research Foundation (grant
   320030_141179).
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NR 55
TC 36
Z9 37
U1 0
U2 23
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0197-4580
EI 1558-1497
J9 NEUROBIOL AGING
JI Neurobiol. Aging
PD MAR
PY 2017
VL 51
BP 1
EP 8
DI 10.1016/j.neurobiolaging.2016.11.014
PG 8
WC Geriatrics & Gerontology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Neurosciences & Neurology
GA EP1UA
UT WOS:000397168600001
PM 28012996
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Chiang, JJ
   Ko, A
   Bower, JE
   Taylor, SE
   Irwin, MR
   Fuligni, AJ
AF Chiang, Jessica J.
   Ko, Ahra
   Bower, Julienne E.
   Taylor, Shelley E.
   Irwin, Michael R.
   Fuligni, Andrew J.
TI Stress, Psychological Resources, and HPA and Inflammatory Reactivity
   During Late Adolescence
SO DEVELOPMENT AND PSYCHOPATHOLOGY
LA English
DT Article
ID CHILDHOOD SOCIOECONOMIC-STATUS; PITUITARY-ADRENOCORTICAL AXIS;
   SHIFT-AND-PERSIST; CORTISOL RESPONSES; FAMILY STRESS; PROINFLAMMATORY
   PHENOTYPE; INDIVIDUAL-DIFFERENCES; AMERICAN ADOLESCENTS; METABOLIC
   SYNDROME; SALIVARY CORTISOL
AB Psychosocial stress during childhood and adolescence is associated with alterations in the hypothalamic-pituitary-adrenal (HPA) axis and with heightened inflammation, both of which are implicated in poor health; however, factors that may protect against these effects relatively early in life are not well understood. Thus, we examined whether psychosocial resources protect against stress-related alterations in the HPA axis and heightened inflammation in a sample of 91 late adolescents. Participants completed measures of various stressors (major life events, daily interpersonal stress, early adversity), and psychosocial resources (mastery, optimism, self-esteem, and positive reappraisal). They also completed the Trier Social Stress Test and provided saliva and blood samples for the assessment of cortisol and interleukin-6 reactivity. Each of the stressors was associated with lower cortisol reactivity. Additionally, associations with major life events and daily stress were moderated by psychological resources, such that more life events and daily stress were associated with decreased HPA reactivity among adolescents with lower levels of psychological resources, but not among those with higher levels of psychological resources. This pattern of findings was observed only for cortisol reactivity and not for interleukin-6 reactivity. Findings suggest that psychological resources may counteract the effects of certain adversity-related decreases in cortisol reactivity.
C1 [Chiang, Jessica J.] Northwestern Univ, 1801 Maple Ave,Suite 2450, Evanston, IL 60201 USA.
   [Ko, Ahra] Los Angeles Cty Dept Mental Hlth, Los Angeles, CA USA.
   [Bower, Julienne E.; Taylor, Shelley E.; Irwin, Michael R.; Fuligni, Andrew J.] Univ Calif Los Angeles, Los Angeles, CA 90024 USA.
C3 Northwestern University; University of California System; University of
   California Los Angeles
RP Chiang, JJ (corresponding author), Northwestern Univ, 1801 Maple Ave,Suite 2450, Evanston, IL 60201 USA.
EM jessica.chiang@northwestern.edu
RI Irwin, Michael/H-4870-2013
OI Irwin, Michael/0000-0002-1502-8431
FU Eunice Kennedy Shriver National Institute of Child Health and Human
   Development [R01HD062547]; UCLA California Center for Population
   Research - National Institute of Child Health and Human Development
   [R24HD041022]; UCLA Older Americans Independence Center - National
   Institute of Aging [P30-AG028748]; UCLA Cousins Center for
   Psychoneuroimmunology; University of California Institute for Mexico;
   US, American Psychological Association; Division 38 of the American
   Psychological Association; National Heart, Lung, and Blood Institute
   Grant [F32-HL134276]
FX This research was supported by funding from the Eunice Kennedy Shriver
   National Institute of Child Health and Human Development (R01HD062547),
   UCLA California Center for Population Research funded by the National
   Institute of Child Health and Human Development (R24HD041022), and the
   UCLA Older Americans Independence Center funded by the National
   Institute of Aging (P30-AG028748), UCLA Cousins Center for
   Psychoneuroimmunology, University of California Institute for Mexico and
   the US, American Psychological Association, and Division 38 of the
   American Psychological Association. The authors' efforts were supported
   by the National Heart, Lung, and Blood Institute Grant F32-HL134276 (to
   J.J.C.).
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NR 112
TC 29
Z9 30
U1 2
U2 22
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
SN 0954-5794
EI 1469-2198
J9 DEV PSYCHOPATHOL
JI Dev. Psychopathol.
PD MAY
PY 2019
VL 31
IS 2
BP 699
EP 712
DI 10.1017/S0954579418000287
PG 14
WC Psychology, Developmental
WE Social Science Citation Index (SSCI)
SC Psychology
GA HV9ZY
UT WOS:000466341900022
PM 30079845
OA Green Accepted, Green Submitted, Bronze
DA 2025-06-11
ER

PT J
AU Yan, LJ
AF Yan, Liang-Jun
TI Pathogenesis of Chronic Hyperglycemia: From Reductive Stress to
   Oxidative Stress
SO JOURNAL OF DIABETES RESEARCH
LA English
DT Review
ID BETA-N-ACETYLGLUCOSAMINE; REACTIVE OXYGEN; INSULIN-RESISTANCE; ALDOSE
   REDUCTASE; POLYOL PATHWAY; HIGH-GLUCOSE; SUPEROXIDE-PRODUCTION;
   DIABETES-MELLITUS; O-GLCNACYLATION; GLYCERALDEHYDE-3-PHOSPHATE
   DEHYDROGENASE
AB Chronic overnutrition creates chronic hyperglycemia that can gradually induce insulin resistance and insulin secretion impairment. These disorders, if not intervened, will eventually be followed by appearance of frank diabetes. The mechanisms of this chronic pathogenic process are complex but have been suggested to involve production of reactive oxygen species (ROS) and oxidative stress. In this review, I highlight evidence that reductive stress imposed by overflux of NADH through the mitochondrial electron transport chain is the source of oxidative stress, which is based on establishments that more NADH recycling by mitochondrial complex I leads to more electron leakage and thus more ROS production. The elevated levels of both NADH and ROS can inhibit and inactivate glyceraldehyde 3-phosphate dehydrogenase (GAPDH), respectively, resulting in blockage of the glycolytic pathway and accumulation of glycerol 3-phospate and its prior metabolites along the pathway. This accumulation then initiates all those alternative glucose metabolic pathways such as the polyol pathway and the advanced glycation pathways that otherwise are minor and insignificant under euglycemic conditions. Importantly, all these alternative pathways lead to ROS production, thus aggravating cellular oxidative stress. Therefore, reductive stress followed by oxidative stress comprises a major mechanism of hyperglycemia-induced metabolic syndrome.
C1 Univ N Texas, Hlth Sci Ctr, UNT Syst Coll Pharm, Dept Pharmaceut Sci, Ft Worth, TX 76107 USA.
C3 University of North Texas System; University of North Texas Health
   Science Center
RP Yan, LJ (corresponding author), Univ N Texas, Hlth Sci Ctr, UNT Syst Coll Pharm, Dept Pharmaceut Sci, 3500 Camp Bowie Blvd,RES-314E, Ft Worth, TX 76107 USA.
EM liang-jun.yan@unthsc.edu
OI Yan, Liang-Jun/0000-0002-5815-5430
FU National Institute of Neurological Disorders and Stroke [R01NS079792]
FX Liang-Jun Yan is supported in part by a Grant from the National
   Institute of Neurological Disorders and Stroke (R01NS079792).
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NR 191
TC 284
Z9 315
U1 9
U2 51
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2314-6745
EI 2314-6753
J9 J DIABETES RES
JI J. Diabetes Res.
PY 2014
VL 2014
AR 137919
DI 10.1155/2014/137919
PG 11
WC Endocrinology & Metabolism; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Research & Experimental Medicine
GA AJ9UZ
UT WOS:000338059700001
PM 25019091
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Delibegovic, M
   Zimmer, D
   Kauffman, C
   Rak, K
   Hong, EG
   Cho, YR
   Kim, JK
   Kahn, BB
   Neel, BG
   Bence, KK
AF Delibegovic, Mirela
   Zimmer, Derek
   Kauffman, Caitlin
   Rak, Kimberly
   Hong, Eun-Gyoung
   Cho, You-Ree
   Kim, Jason K.
   Kahn, Barbara B.
   Neel, Benjamin G.
   Bence, Kendra K.
TI Liver-Specific Deletion of Protein-Tyrosine Phosphatase 1B (PTP1B)
   Improves Metabolic Syndrome and Attenuates Diet-Induced Endoplasmic
   Reticulum Stress
SO DIABETES
LA English
DT Article
ID INSULIN-RESISTANCE; GLUCOSE-HOMEOSTASIS; GENE-EXPRESSION; HEPATIC
   GLUCONEOGENESIS; FATTY-ACIDS; ER STRESS; IN-VIVO; MICE; RECEPTOR;
   OBESITY
AB OBJECTIVE-The protein tyrosine phosphatase PTP1B is a negative regulator of insulin signaling; consequently, mice deficient in PTP1B are hypersensitive to insulin. Because PTP1B(-/-) mice have diminished fat stores, the extent to which PTP1B directly regulates glucose homeostasis is unclear. Previously, we showed that brain-specific PTP1B(-/-) mice are protected against high-fat diet-induced obesity and glucose intolerance, whereas muscle-specific PTP1B(-/-) mice have increased insulin sensitivity independent of changes in adiposity. Here we studied the role of liver PTP1B in glucose homeostasis and lipid metabolism.
   RESEARCH DESIGN AND METHODS-We analyzed body mass/adiposity, insulin sensitivity, glucose tolerance, and lipid metabolism in liver-specific PTP1B(-/-) and PTP1Bfl/fl control mice, fed a chow or high-fat diet.
   RESULTS-Compared with normal littermates, liver-specific PTP1B(-/-) mice exhibit improved glucose homeostasis and lipid profiles, independent of changes in adiposity. Liver-specific PTP1B(-/-) mice have increased hepatic insulin signaling, decreased expression of gluconeogenic genes PEPCK mid G-6-Pase, enhanced insulin-induced suppression of hepatic glucose production, and improved glucose tolerance. Liver-specific PTP1B(-/-) mice exhibit decreased triglyceride and cholesterol levels and diminished expression of lipogenic genes SREBPs, FAS, and ACC. Liver-specific PTP1B deletion also protects against high-fat diet-induced endoplasmic reticulum stress response in vivo, as evidenced by decreased phosphorylation of p38MAPK, JNK, PERK, and eIF2 alpha and lower expression of the transcription factors C/EBP homologous protein and spliced X box-binding protein 1.
   CONCLUSIONS-Liver PTP1B plays an important role in glucose and lipid metabolism, independent of alterations in adiposity. Inhibition of PTP1B in peripheral tissues may be useful for the treatment of metabolic syndrome and reduction of cardiovascular risk in addition to diabetes. Diabetes 58:590-599, 2009
C1 [Zimmer, Derek; Kauffman, Caitlin; Rak, Kimberly; Bence, Kendra K.] Univ Penn, Sch Vet Med, Dept Anim Biol, Philadelphia, PA 19104 USA.
   [Delibegovic, Mirela; Neel, Benjamin G.] Beth Israel Deaconess Med Ctr, Canc Biol Program, Boston, MA 02215 USA.
   [Delibegovic, Mirela; Kahn, Barbara B.; Neel, Benjamin G.] Harvard Univ, Sch Med, Boston, MA 02115 USA.
   [Hong, Eun-Gyoung; Kim, Jason K.] Penn State Univ, Coll Med, Dept Cellular & Mol Physiol, Hershey, PA USA.
   [Hong, Eun-Gyoung; Cho, You-Ree; Kim, Jason K.] Yale Univ, Sch Med, Dept Internal Med, Sect Endocrinol & Metab, New Haven, CT 06510 USA.
   [Kahn, Barbara B.] Beth Israel Deaconess Med Ctr, Dept Med, Div Endocrinol Diabet & Metab, Boston, MA 02215 USA.
   [Delibegovic, Mirela] Univ Aberdeen, Sch Biol Sci, Aberdeen, Scotland.
   [Neel, Benjamin G.] Ontario Canc Inst, Div Stem Cell & Dev Biol, Toronto, ON M4X 1K9, Canada.
C3 University of Pennsylvania; Harvard University; Harvard University
   Medical Affiliates; Beth Israel Deaconess Medical Center; Harvard
   University; Harvard Medical School; Pennsylvania Commonwealth System of
   Higher Education (PCSHE); Pennsylvania State University; Penn State
   Health; Yale University; Harvard University; Harvard University Medical
   Affiliates; Beth Israel Deaconess Medical Center; University of
   Aberdeen; University of Toronto; University Health Network Toronto
RP Bence, KK (corresponding author), Univ Penn, Sch Vet Med, Dept Anim Biol, Philadelphia, PA 19104 USA.
EM m.delibegovic@abdn.ac.uk; kbence@vet.upenn.edu
OI Delibegovic, Mirela/0000-0001-6193-3152; Bence,
   Kendra/0000-0002-5879-4726; Kim, Jason/0000-0002-7185-042X
FU National Institutes of Health (NIH) [DK 60838, DK 60839, R37 CA49152,
   U24-DK59635]; Physiology Core Grant [DK57521]; American Diabetes
   Association [1-04-RA-47]; Research Councils UK; Diabetes UK project;
   Royal Society; Penn Center for Molecular Studies in Digestive and Liver
   Disease [DK50306]; University of Pennsylvania Research Foundation; USDA;
   Pennsylvania State Department of Health
FX This work was supported by National Institutes of Health (NIH) Grants DK
   60838 (to B.B.K. and B.G.N.), DK 60839 (to B.B.K.), R37 CA49152 (to
   B.G.N.), and U24-DK59635 (to J.K.K.); the Physiology Core Grant DK57521
   (to B.B.K.); and a Research Grant from the American Diabetes Association
   (to B.G.N.). M.D. was the recipient of a postdoctoral fellowship from
   the American Heart Association and is currently supported by Research
   Councils UK Fellowship, Diabetes UK project grant, and the Royal Society
   Research Grant. K.K.B. was supported by a Penn Center for Molecular
   Studies in Digestive and Liver Disease Pilot Grant (DK50306), University
   of Pennsylvania Research Foundation, and the USDA (Section 1433 Animal
   Health and Disease Formula Grant). Lipid analysis was performed at the
   Vanderbilt MMPC Lipid Core (DK59637). Parts of this study were performed
   at the Penn State Mouse Metabolic Phenotyping Center and the Yale Mouse
   Metabolic Phenotyping Center, and the study was supported by grants from
   the American Diabetes Association (1-04-RA-47 to J.K.K.) and the
   Pennsylvania State Department of Health (to J.K.K.).B.G.N. and B.B.K.
   have equity in Ceptyr Inc, a company trying to develop PTP1B inhibitors,
   and B.B.K. also serves on its Scientific Advisory Board. No other
   potential conflicts of interest relevant to this article were
   reported.We thank C. Ronald Kahn (Joslin Diabetes Center) for the
   Alb-Cre mice.
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NR 49
TC 230
Z9 264
U1 3
U2 16
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0012-1797
EI 1939-327X
J9 DIABETES
JI Diabetes
PD MAR
PY 2009
VL 58
IS 3
BP 590
EP 599
DI 10.2337/db08-0913
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 414FE
UT WOS:000263848500013
PM 19074988
OA hybrid, Green Accepted, Green Published
DA 2025-06-11
ER

PT J
AU Bianchi, VE
   Ribisl, PM
AF Bianchi, Vittorio E.
   Ribisl, Paul M.
TI Reactive Oxygen Species Response to Exercise Training and Weight Loss in
   Sedentary Overweight and Obese Female Adults
SO JOURNAL OF CARDIOPULMONARY REHABILITATION AND PREVENTION
LA English
DT Article
DE community setting intervention; exercise training; oxidative stress;
   reactive oxygen species; weight loss
ID SYSTEMIC OXIDATIVE STRESS; METABOLIC SYNDROME; CAPACITY; TRIAL; MEN
AB PURPOSE: Reactive oxygen species (ROS) are implicated in cardiovascular disease and in the pathogenesis of type 2 diabetes and its complications, and it has been shown to increase insulin resistance. The purpose of this study was to examine the effect of aerobic exercise training and weight loss on ROS in overweight and obese patients as applied in a community clinical setting.
   METHODS: Fifty healthy female clinic patients (M SEM: age, 41.0 1.8 years; body mass index, 28.2 +/- 0.8 kg/m(2)), free of cardiovascular events and not on drug therapy were evaluated before and after 3 months of dietary restriction (similar to 150 to 300 kcal/day deficit) and aerobic training (3 days/week for 1 hour at similar to 75% (V)over dotO(2)max). Measures included ROS, maximal power (kg/min) on cycle ergometry, postexercise heart rate recovery responses at 1 and 2 minutes, and selected anthropometric and hematologic variables.
   RESULTS: Significant (P < .01) improvements were observed after aerobic training and weight loss in body weight in kilograms (-7.1%); maximal power in kg/min (+32.6%), ROS in U.CARR (Carratelli units) (-25.7%); and heart rate recovery 1 minute in beats per minute (-37.6%) following the program. Significant improvements were also noted in other anthropometric, cardiovascular, and hematologic measures.
   CONCLUSIONS: A 12-week program of nutritional and exercise intervention in overweight/obese sedentary women improves levels of oxidative stress when accompanied by weight loss and improved fitness. More than restricted caloric intake, physical activity at a relatively high intensity was effective in improving cardiovascular risk markers. The reduction in ROS may be an additional mechanism by which physical activity may contribute to preventing metabolic syndrome and subsequent atherosclerotic disease.
C1 [Bianchi, Vittorio E.] Ctr Clin Nutr Metab & Phys Performance, San Marino, Italy.
   [Ribisl, Paul M.] Wake Forest Univ, Dept Hlth & Exercise Sci, Winston Salem, NC 27109 USA.
C3 Wake Forest University
RP Ribisl, PM (corresponding author), Wake Forest Univ, Dept Hlth & Exercise Sci, 303 Gymnasium, Winston Salem, NC 27109 USA.
EM pmribisl@gmail.com
RI bianchi, vittorio/I-1396-2013
OI Bianchi, Vittorio/0000-0003-3689-9970
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NR 15
TC 10
Z9 12
U1 0
U2 11
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1932-7501
EI 1932-751X
J9 J CARDIOPULM REHABIL
JI J. Cardiopulm. Rehabil. Prev.
PD JUL-AUG
PY 2015
VL 35
IS 4
BP 263
EP 267
DI 10.1097/HCR.0000000000000114
PG 5
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA CM8IK
UT WOS:000357942700006
PM 25806958
DA 2025-06-11
ER

PT J
AU Hagiwara, S
   Gohda, T
   Tanimoto, M
   Ito, T
   Murakoshi, M
   Ohara, I
   Yamazaki, T
   Matsumoto, M
   Horikoshi, S
   Funabiki, K
   Tomino, Y
AF Hagiwara, Shinji
   Gohda, Tomohito
   Tanimoto, Mitsuo
   Ito, Takamichi
   Murakoshi, Maki
   Ohara, Ikko
   Yamazaki, Takahiko
   Matsumoto, Masakazu
   Horikoshi, Satoshi
   Funabiki, Kazuhiko
   Tomino, Yasuhiko
TI Effects of pyridoxamine (K-163) on glucose intolerance and obesity in
   high-fat diet C57BL/6J mice
SO METABOLISM-CLINICAL AND EXPERIMENTAL
LA English
DT Article
ID TYPE-2 DIABETIC-NEPHROPATHY; INDUCED INSULIN-RESISTANCE; ACTIVATED
   SIGNALING PATHWAYS; INCREASED OXIDATIVE STRESS; GLYCATION END-PRODUCTS;
   BETA-CELL DYSFUNCTION; ALPHA-LIPOIC ACID; METABOLIC SYNDROME; 3T3-L1
   ADIPOCYTES; GLUT4 TRANSLOCATION
AB Advanced glycation end products (AGEs) contribute to the pathogenesis of diabetes-associated complications. Previously, we reported the possible effect of pyridoxamine (K-163), an AGE inhibitor, on improvement of glucose intolerance in type 2 diabetes mellitus KK-A(y)/Ta mice. Recently, AGEs and oxidative stress have been shown to induce insulin resistance. The objective of the present study is to examine the effect of pyridoxamine on glucose intolerance and oxidative stress. C57BL/6J mice were divided into 3 groups as follows: low-fat diet, high-fat diet, and high-fat diet with pyridoxamine treatment. Body and adipose tissue weight, serum insulin, hydrogen peroxide, malondialdehyde and AGE, and urinary 8-hydroxy-2'-deoxyguanosine levels were measured. Nicotinamide adenine dinucleotide phosphate subunits, antioxidant enzymes, and adipocytokine messenger RNA expressions in the adipose tissues were evaluated. Akt/protein kinase B activity and glucose transporter 4 translocation in skeletal muscle were also evaluated. Body and adipose tissue weights of the pyridoxamine treatment group were significantly decreased compared with those of the high-fat diet group. Pyridoxamine attenuated serum hydrogen peroxide, malondialdehyde and AGE, and urinary 8-hydroxy-2'-deoxyguanosine and nicotinamide adenine dinucleotide phosphate oxidase expression-, increased antioxidant enzyme expression; and improved dysregulation of adipocytokines in adipose tissues. Pyridoxamine improved blood glucose levels after glucose injection and fasting hyperinsulinemia. Suppressed Akt/protein kinase B activity and glucose transporter 4 translocation in skeletal muscle in high-fat diet mice were improved by pyridoxamine treatment. It appears that the antioxidative effect of pyridoxamine is associated with improvement of glucose intolerance and obesity in C57BL/6J mice fed a high-fat diet. We assume that pyridoxamine may be useful in the treatment of the obesity-associated metabolic syndrome. (C) 2009 Elsevier Inc. All rights reserved.
C1 [Hagiwara, Shinji; Gohda, Tomohito; Tanimoto, Mitsuo; Ito, Takamichi; Murakoshi, Maki; Ohara, Ikko; Yamazaki, Takahiko; Matsumoto, Masakazu; Horikoshi, Satoshi; Tomino, Yasuhiko] Juntendo Univ, Sch Med, Dept Internal Med, Div Nephrol, Tokyo 1138421, Japan.
   [Funabiki, Kazuhiko] Juntendo Tokyo Koto Geriatr Med Ctr, Dept Hypertens & Nephrol, Tokyo 1360075, Japan.
   [Hagiwara, Shinji] Juntendo Univ, Grad Sch Med, Sportol Ctr, Tokyo 1138421, Japan.
C3 Juntendo University; Juntendo University; Juntendo University
RP Tomino, Y (corresponding author), Juntendo Univ, Sch Med, Dept Internal Med, Div Nephrol, Tokyo 1138421, Japan.
EM yasu@juntendo.ac.jp
RI GOHDA, TOMOHITO/Y-6867-2019
FU Ministry of Education, Culture, Sports, Science, and Technology of Japan
FX We thank Kowa (Tokyo, Japan) for providing K-163. We also thank Ms
   Terumi Shibata, Dr Mariko Tamano, Mr Yoshihiro Kubota, and Ms Mayumi
   Ishiwata. for their skillful technical support and advice. This study
   was partly supported by High Technology Research Center Grant from the
   Ministry of Education, Culture, Sports, Science, and Technology of
   Japan.
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NR 47
TC 28
Z9 36
U1 0
U2 10
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0026-0495
EI 1532-8600
J9 METABOLISM
JI Metab.-Clin. Exp.
PD JUL
PY 2009
VL 58
IS 7
BP 934
EP 945
DI 10.1016/j.metabol.2009.02.033
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 460LZ
UT WOS:000267190500006
PM 19427656
DA 2025-06-11
ER

PT J
AU Perras, B
   Berkemeier, E
   Rasch, B
   Fehm, HL
   Born, J
AF Perras, B.
   Berkemeier, E.
   Rasch, B.
   Fehm, H. L.
   Born, J.
TI PreproTRH(158-183) fails to affect pituitary-adrenal response
   to CRH/vasopressin in man:: A pilot study
SO NEUROPEPTIDES
LA English
DT Article
DE cortisol; ACTH; PreproTRH((158-183)); PreproTRH((178-199)); human
ID RELEASE-INHIBITING FACTOR; ADRENOCORTICAL AXIS; SLEEP; SECRETION;
   HORMONE; STRESS; HUMANS; NEUROENDOCRINE; HYPOTHALAMUS; WAKEFULNESS
AB Non-glucocorticoid inhibitors of the HPA-system are of utmost interest in the treatment of diseases with impaired regulation of this system, like the metabolic syndrome and depression. In rats, a fragment of the thyreotropin-releasing hormone (TRH) preprohormone, preproTRH((178-199)), has been demonstrated to inhibit basal and stimulated secretion of cortisol. Our pilot study aimed to explore the first time similar effects of the homologue peptide preproTRH((158-193)) in healthy humans. In a double-blind within-subject comparison, eight healthy young men were infused intravenously with placebo and preproTRH((158-183)) at varying doses of 5, 10, 25 and 50 mg/kg of body weight. After 15 min of infusion a corticotropin-releasing hormone (CRH)/vasopressin-test was performed. Plasma concentrations of pituitary hormones and free thyroxine, blood pressure, heart rate and feelings of activation and mood were assessed repeatedly at close intervals. Individual hormone profiles and collapsed data across all doses did not reveal any effects of preproTRH((158-183)) on HPA-activity, although it increased TSH and fT4, stimulated the release of GH and increased systolic blood pressure in the course of the experiment (p < 0.05, for all effects). Self-reports indicated enhanced feelings of activation and general well-being following preproTRH (p < 0.05). Our data exclude a substantial inhibitory effect of preproTRH((158-183)) on HPA secretory activity and, thus, contrast with findings in rats. In humans, the peptide appears to even exert an albeit weak stimulatory effect on autonomic stress systems as indicated by increased cardiovascular activity in combination with enhanced subjective arousal. (C) 2007 Elsevier Ltd. All rights reserved.
C1 Med Univ Lubeck, Dept Internal Med 1, D-23538 Lubeck, Germany.
   Med Univ Lubeck, Dept Neuroendocrinol, D-23538 Lubeck, Germany.
C3 University of Lubeck; University of Lubeck
RP Perras, B (corresponding author), Med Univ Lubeck, Dept Internal Med 1, D-23538 Lubeck, Germany.
EM Perras@kfg.mu-luebeck.de
RI Born, Jan/K-2596-2016; Rasch, Bjorn/A-3119-2015
OI Born, Jan/0000-0002-1847-6248; Rasch, Bjorn/0000-0001-7607-3415
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NR 21
TC 1
Z9 1
U1 0
U2 1
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0143-4179
J9 NEUROPEPTIDES
JI Neuropeptides
PD AUG
PY 2007
VL 41
IS 4
BP 233
EP 238
DI 10.1016/j.npep.2007.03.002
PG 6
WC Endocrinology & Metabolism; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology
GA 197WA
UT WOS:000248586000005
PM 17482675
DA 2025-06-11
ER

PT J
AU Xu, D
   Xia, LP
   Zhang, BJ
   Shen, L
   Lei, YY
   Liu, L
   Zhang, L
   Magdalou, J
   Wang, H
AF Xu, Dan
   Xia, Li-ping
   Zhang, Ben-jian
   Shen, Lang
   Lei, You-ying
   Liu, Lian
   Zhang, Li
   Magdalou, Jacques
   Wang, Hui
TI Prenatal nicotine exposure enhances the susceptibility to metabolic
   syndrome in adult offspring rats fed high-fat diet via alteration of HPA
   axis-associated neuroendocrine metabolic programming
SO ACTA PHARMACOLOGICA SINICA
LA English
DT Article
DE nicotine; intrauterine growth retardation;
   hypothalamic-pituitary-adrenal axis; neuroendocrine metabolic
   programming; high-fat diet; stress; metabolic syndrome; insulin;
   glucose; lipid; gender difference
ID PITUITARY-ADRENAL AXIS; INSULIN-RESISTANCE; MATERNAL SMOKING;
   GENE-EXPRESSION; INDUCED OBESITY; BLOOD-PRESSURE; FETAL ORIGINS; GROWTH;
   STRESS; PREGNANCY
AB Aim: Prenatal nicotine exposure (PNE) alters the hypothalamic-pituitary-adrenocortical (HPA) axis-associated neuroendocrine metabolic programming in intrauterine growth retardation offspring rats. In this study we aimed to clarify the susceptibility to metabolic diseases of PNE offspring rats fed a high-fat diet.
   Methods: Maternal Wistar rats were injected with nicotine (1.0 mg/kg, sc) twice per day from gestational day 11 until full-term delivery, and all pups were fed a high-fat diet after weaning and exposed to unpredictable chronic stress (UCS) during postnatal weeks 18-20. Blood samples were collected before and after chronic stress, and serum ACTH, corticosterone, glucose, insulin, total cholesterol, triglyceride and free fatty acids levels were measured. The hypothalamus, pituitary gland and liver were dissected for histological studies.
   Results: UCS significantly increased the serum ACTH, corticosterone and insulin levels as well as the insulin resistant index without changing the serum glucose, total cholesterol, triglyceride and free fatty acids levels in adult offspring rats without PNE. The body weight of PNE offspring rats presented a typical "catch-up" growth pattern. PNE not only aggravated the UCS-induced changes in the HPA axis programmed alteration (caused further increases in the serum ACTH and corticosterone levels), but also significantly changed the glucose and lipid metabolism after UCS (caused further increases in the serum glucose level and insulin resistant index, and decrease in the serum free fatty acids). The effects of PNE on the above indexes after UCS showed gender differences. Pathological studies revealed that PNE led to plenty of lipid droplets in multiple organs.
   Conclusion: PNE enhances not only the HPA axis, but also the susceptibility to metabolic diseases in adult offspring rats fed a high-fat diet after UCS in a gender-specific manner and enhances the susceptibility to metabolic diseases in adult offspring rats fed a high-fat diet.
C1 [Xu, Dan; Xia, Li-ping; Zhang, Ben-jian; Shen, Lang; Lei, You-ying; Liu, Lian; Zhang, Li; Wang, Hui] Wuhan Univ, Basic Med Sch, Dept Pharmacol, Wuhan 430071, Peoples R China.
   [Xu, Dan; Wang, Hui] Wuhan Univ, Res Ctr Food & Drug Evaluat, Wuhan 430071, Peoples R China.
   [Magdalou, Jacques] Nancy Univ, Fac Med, CNRS, UMR 7561, Vandoeuvre Les Nancy, France.
C3 Wuhan University; Wuhan University; Universite de Lorraine; Centre
   National de la Recherche Scientifique (CNRS)
RP Wang, H (corresponding author), Wuhan Univ, Basic Med Sch, Dept Pharmacol, Wuhan 430071, Peoples R China.
EM wanghui19@whu.edu.cn
RI Zhang, Benjian/ABC-1130-2020
FU National Natural Science Foundation of China [30830112, 81072709,
   81220108026, 81371483]; Chinese Ministry of Education [V200801]
FX This work was supported by grants from the National Natural Science
   Foundation of China (No 30830112, 81072709, 81220108026, and 81371483)
   and the Key Grant Project of the Chinese Ministry of Education (No
   V200801).
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NR 51
TC 34
Z9 39
U1 2
U2 19
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1671-4083
EI 1745-7254
J9 ACTA PHARMACOL SIN
JI Acta Pharmacol. Sin.
PD DEC
PY 2013
VL 34
IS 12
BP 1526
EP 1534
DI 10.1038/aps.2013.171
PG 9
WC Chemistry, Multidisciplinary; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Pharmacology & Pharmacy
GA 269UV
UT WOS:000328268600006
PM 24270239
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Van Hoorenbeeck, K
   Franckx, H
   Debode, P
   Aerts, P
   Wouters, K
   Ramet, J
   Van Gaal, LF
   Desager, KN
   De Backer, WA
   Verhulst, SL
AF Van Hoorenbeeck, Kim
   Franckx, Hilde
   Debode, Patrick
   Aerts, Petra
   Wouters, Kristien
   Ramet, Jose
   Van Gaal, Luc F.
   Desager, Kristine N.
   De Backer, Wilfried A.
   Verhulst, Stijn L.
TI Weight Loss and Sleep-Disordered Breathing in Childhood Obesity: Effects
   on Inflammation and Uric Acid
SO OBESITY
LA English
DT Article
ID SYSTEMIC INFLAMMATION; METABOLIC SYNDROME; CHILDREN; ADOLESCENTS;
   OVERWEIGHT; APNEA; ADENOTONSILLECTOMY; PREVALENCE
AB Sleep-disordered breathing (SDB) is prevalent in childhood obesity. It may be an independent risk factor for the metabolic syndrome. Possible mechanisms are inflammation and oxidative stress. Adenotonsillectomy in childhood obesity is associated with a high recurrence rate and risk of postoperative weight gain. Therefore, this study assessed the effects of SDB on inflammation and oxidative stress in childhood obesity before and after weight loss. We included 132 obese subjects between 10 and 18 years consecutively. Median age was 15.4 years (10.1-18.0). Mean BMI z-score was 2.72 +/- 0.42. Leukocytes and differentiation, high sensitivity C-reactive protein (hs-CRP), and uric acid (UA) were determined at baseline and subjects underwent a sleep assessment. SDB was diagnosed in 39%. Linear regression analysis showed an association between UA(log) and oxygen desaturation index(log) (ODI(log)) (r = 0.20; P = 0.03), between leukocytes log and respiratory disturbance index(log) (RDI(log)) (r = 0.23; P = 0.01), and between lymphocytes(log) and RDI(log) (r = 0.19; P = 0.04). Follow-up was organized after 4-6 months of treatment. Median decrease in BMI z-score was 32%. Laboratory measurements were repeated. Subjects with SDB at baseline underwent a second sleep study. Of these 49 subjects, 12 showed residual SDB. This corresponds with a treatment success rate of 71%. Unlike changes in inflammatory markers, improvements in UA were associated with improvements in RDI and ODI (respectively: r = 0.44; P = 0.007, r = 0.41; P = 0.01). In conclusion, weight loss is effective in treating obese children with SDB. At baseline, a link exists between inflammation and SDB. Oxidative stress is reflected by UA at baseline and the concentration decreases after treatment according to improvements in SDB.
C1 [Van Hoorenbeeck, Kim; Aerts, Petra; Ramet, Jose; Van Gaal, Luc F.; De Backer, Wilfried A.] Univ Antwerp, Lab Expt Med & Pediat, B-2020 Antwerp, Belgium.
   [Franckx, Hilde; Debode, Patrick] Zeepreventorium, De Haan, Belgium.
   [Wouters, Kristien] Univ Antwerp Hosp, Dept Stat, Edegem, Belgium.
   [Ramet, Jose; Desager, Kristine N.; Verhulst, Stijn L.] Univ Antwerp Hosp, Dept Pediat, Edegem, Belgium.
   [Van Gaal, Luc F.] Univ Antwerp Hosp, Dept Endocrinol Diabetol & Metab, Edegem, Belgium.
   [De Backer, Wilfried A.] Univ Antwerp Hosp, Dept Pulmonol, Edegem, Belgium.
C3 University of Antwerp; University of Antwerp; University of Antwerp;
   University of Antwerp; University of Antwerp
RP Van Hoorenbeeck, K (corresponding author), Univ Antwerp, Lab Expt Med & Pediat, B-2020 Antwerp, Belgium.
EM kim.vanhoorenbeeck@ua.ac.be
RI Van Hoorenbeeck, Kim/GLS-2363-2022; Wouters, Kristien/ADM-4146-2022;
   Verhulst, Stijn/B-1702-2008
OI Van Hoorenbeeck, Kim/0000-0002-8812-4440; Verhulst,
   Stijn/0000-0002-1922-9716; Wouters, Kristien/0000-0001-9263-186X
CR Amin R, 2008, AM J RESP CRIT CARE, V177, P654, DOI 10.1164/rccm.200710-1610OC
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NR 23
TC 50
Z9 53
U1 0
U2 9
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 1930-7381
J9 OBESITY
JI Obesity
PD JAN
PY 2012
VL 20
IS 1
BP 172
EP 177
DI 10.1038/oby.2011.282
PG 6
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 866SB
UT WOS:000298401400020
PM 21938074
OA Bronze
DA 2025-06-11
ER

PT J
AU Alkazemi, D
   Egeland, G
   Vaya, J
   Meltzer, S
   Kubow, S
AF Alkazemi, Dalal
   Egeland, Grace
   Vaya, Jacob
   Meltzer, Sara
   Kubow, Stan
TI Oxysterol as a Marker of Atherogenic Dyslipidemia in Adolescence
SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Article
ID LOW-DENSITY-LIPOPROTEIN; BODY-MASS-INDEX; OXIDATIVE STRESS;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; CARDIOVASCULAR-DISEASE;
   DIABETES-MELLITUS; OBESE CHILDREN; VITAMIN-E; PLASMA
AB Context: Oxysterols represent potentially important oxidative stress biomarkers in adolescence.
   Objective: The objective of the study was to examine the relationship between the concentrations of serum enzymatically and nonenzymatically generated oxysterols, measures of obesity, and metabolic components including insulin resistance and levels of blood pressure and serum lipids.
   Design: This was a cross-sectional study.
   Setting: All subjects were examined between 2003 and 2005 at a hospital, a part of a follow-up evaluation mother-daughter pairs representing pregnancies affected or unaffected by gestational diabetes that resulted in the deliveries in 1989-1991.
   Subjects: Subjects included a subset (n = 89) of the total study population of 189 adolescent girls with a mean age of 15.32 +/- 0.65 yr and body mass index of 22.54 +/- 3.98 kg/m(2).
   Main Outcome Measures: Measures included serum levels of the oxysterols 7 alpha-hydroxy-cholesterol, 7 beta-hydroxycholesterol, and 7-ketocholesterol; and body mass index, homeostasis model assessment insulin resistance index, fasting insulin, fasting glucose, blood pressure, total cholesterol, non-high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, and apolipoprotein B (ApoB).
   Results: Serum oxysterol concentrations in the adolescent cohort correlated positively with insulin (P < 0.05), total cholesterol (P < 0.05), non-high-density lipoprotein cholesterol (P < 0.05), low-density lipoprotein cholesterol (P < 0.05), and ApoB (P < 0.01). ApoB and fasting insulin were found to be the major determinants of serum oxysterols after adjustment for body mass index. Being a daughter of gestational diabetes pregnancy alone did not seem to be a predisposing factor to increased oxidative stress in our cohort.
   Conclusion: Serum oxysterol concentrations increase with obesity, insulin, and ApoB, which are established derangements associated with the metabolic syndrome. (J Clin Endocrinol Metab 93: 4282-4289, 2008)
C1 [Alkazemi, Dalal; Egeland, Grace; Kubow, Stan] McGill Univ, Sch Dietet & Human Nutr, Ste Anne De Bellevue, PQ H9X 3V9, Canada.
   [Vaya, Jacob] Migal Galilee Technol Ctr, Lab Nat Med Cpds, IL-11016 Kiryat Shmona, Israel.
   [Meltzer, Sara] McGill Univ, Ctr Hlth, Royal Victoria Hosp, Div Endocrinol & Metab,Dept Med, Montreal, PQ H3H 2R9, Canada.
C3 McGill University; McGill University; Royal Victoria Hospital
RP Kubow, S (corresponding author), McGill Univ, Sch Dietet & Human Nutr, 21 111 Lakeshore Rd, Ste Anne De Bellevue, PQ H9X 3V9, Canada.
EM stan.kubow@mcgill.ca
RI Meltzer, Sara/AAF-3564-2020; Kubow, Stan/AAJ-6913-2021; Alkazemi, Dalal
   Usamah Zaid/E-5481-2018
OI Alkazemi, Dalal Usamah Zaid/0000-0001-9349-2144; Kubow,
   Stan/0000-0001-5831-9880
FU Canadian Institutes of Health Research
FX This work was supported by a grant from the Canadian Institutes of
   Health Research.
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NR 40
TC 50
Z9 51
U1 0
U2 3
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0021-972X
EI 1945-7197
J9 J CLIN ENDOCR METAB
JI J. Clin. Endocrinol. Metab.
PD NOV
PY 2008
VL 93
IS 11
BP 4282
EP 4289
DI 10.1210/jc.2008-0586
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 368ZI
UT WOS:000260661900018
PM 18713821
DA 2025-06-11
ER

PT J
AU Tan, RYM
   Grigg, J
   Kulkarni, J
AF Tan, Raelene Y. M.
   Grigg, Jasmin
   Kulkarni, Jayashri
TI Borderline personality disorder and polycystic ovary syndrome: A review
   of the literature
SO AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
LA English
DT Review
DE Borderline personality disorder; psychiatric disorder; polycystic ovary
   syndrome; testosterone; hyperandrogenism
ID ADRENAL ANDROGEN EXCESS; CORTICOTROPIN-RELEASING-FACTOR; CHILDHOOD
   EXPERIENCES; COMMUNITY SAMPLE; RISK-FACTORS; TESTOSTERONE LEVELS;
   METABOLIC SYNDROME; LIFE EVENTS; WOMEN; PREVALENCE
AB Objective: This review examines the existing evidence for the relationship between borderline personality disorder and polycystic ovary syndrome, and to identify commonalities in etiological mechanisms of borderline personality disorder and polycystic ovary syndrome that might explain the relationship between these seemingly disparate disorders.
   Methods: A search of Medline, EMBASE and Cochrane Central was undertaken on 5 December 2016 to identify studies investigating women with borderline personality disorder and polycystic ovary syndrome (or symptoms and markers specific to polycystic ovary syndrome).
   Results: Nine studies were identified, including three cross-sectional studies investigating symptoms of polycystic ovary syndrome in women with borderline personality disorder, two cross-sectional and one cohort study examining the prevalence of psychiatric diagnoses in women with polycystic ovary syndrome and three case reports of comorbid borderline personality disorder and polycystic ovary syndrome.
   Conclusion: Overall, the literature shows women with borderline personality disorder to have higher than expected serum androgen levels and incidence of polycystic ovaries, which can be key features of polycystic ovary syndrome. However, this research is still in its infancy, which limits our understanding of this potential comorbid phenomenon. Given the emerging anecdotal and empirical evidence to date, a theoretical discussion of the potential psychoneuroendocrinological mechanism underlying the borderline personality disorder and polycystic ovary syndrome comorbidity is provided. Further rigorous studies using standardized diagnostic criteria for polycystic ovary syndrome are warranted. Specifically, the use of prospective controlled cohort studies may be able to determine the causality and temporality of observed comorbid borderline personality disorder and polycystic ovary syndrome.
C1 [Tan, Raelene Y. M.; Grigg, Jasmin; Kulkarni, Jayashri] Monash Alfred Psychiat Res Ctr MAPrc, Level 4,607 St Kilda Rd, Melbourne, Vic 3004, Australia.
   [Tan, Raelene Y. M.] Monash Univ, Melbourne, Vic, Australia.
C3 Monash University; Monash University
RP Kulkarni, J (corresponding author), Monash Alfred Psychiat Res Ctr MAPrc, Level 4,607 St Kilda Rd, Melbourne, Vic 3004, Australia.
EM jayashri.kulkarni@monash.edu
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NR 87
TC 14
Z9 16
U1 0
U2 21
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0004-8674
EI 1440-1614
J9 AUST NZ J PSYCHIAT
JI Aust. N. Z. J. Psych.
PD FEB
PY 2018
VL 52
IS 2
BP 117
EP 128
DI 10.1177/0004867417730650
PG 12
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA FV0FQ
UT WOS:000424231800005
PM 28891300
OA Bronze
DA 2025-06-11
ER

PT J
AU Trattner, H
   Blüml, S
   Steiner, I
   Plut, U
   Radakovic, S
   Tanew, A
AF Trattner, H.
   Blueml, S.
   Steiner, I.
   Plut, U.
   Radakovic, S.
   Tanew, A.
TI Quality of life and comorbidities in palmoplantar pustulosis - a
   cross-sectional study on 102 patients
SO JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
LA English
DT Article
ID TISSUE TRANSGLUTAMINASE; PSORIASIS; HEALTH; PREVALENCE; INFECTION; RISK
AB BackgroundAssociation of palmoplantar pustulosis (PPP) with metabolic and autoimmune diseases has been reported in mostly small case series or anecdotal cases.
   ObjectiveTo assess health-related quality of life and prevalence of comorbidities in a large cohort of PPP patients.
   MethodsWe conducted a cross-sectional study on patients with either active or past PPP. Disease severity was measured by the Palmoplantar Pustulosis Area and Severity Index (ppPASI). Quality of life was assessed by the Dermatology Life Quality Index (DLQI). Comorbidities were evaluated by medical history, blood examination, stool testing for Helicobacter pylori antigen and screening tools for depression and psoriatic arthritis.
   ResultsA total of 102 patients (87 women, 15 men) with a mean age of 52.614.1years were evaluated. The mean DLQI was 7 +/- 6. Comorbidities were frequent and consisted of hypercholesterolaemia (38%), hypertension (32%), obesity (27%), metabolic syndrome (26%), depression (24%), diabetes (19%), autoimmune thyroiditis (16%) and psoriatic arthritis (16%).
   ConclusionPatients with PPP have an impaired quality of life and a broad range of comorbidities. Contrary to other reports, our investigation failed to show an association between PPP and coeliac disease or H.pylori infection.
C1 [Trattner, H.; Plut, U.; Radakovic, S.; Tanew, A.] Med Univ Vienna, Dept Dermatol, Vienna, Austria.
   [Blueml, S.] Med Univ Vienna, Dept Rheumatol, Vienna, Austria.
   [Steiner, I.] Med Univ Vienna, Ctr Med Stat Informat & Intelligent Syst, Sect Med Stat, Vienna, Austria.
C3 Medical University of Vienna; Medical University of Vienna; Medical
   University of Vienna
RP Trattner, H (corresponding author), Med Univ Vienna, Dept Dermatol, Vienna, Austria.
EM hannes.trattner@meduniwien.ac.at
OI Trattner, Hannes/0000-0002-1706-0726; Bluml,
   Stephan/0000-0002-2758-4400; Tanew, M.D., Adrian/0000-0002-4433-2790
CR [Anonymous], 2015, STAT AUSTRIA
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NR 21
TC 44
Z9 47
U1 0
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0926-9959
EI 1468-3083
J9 J EUR ACAD DERMATOL
JI J. Eur. Acad. Dermatol. Venereol.
PD OCT
PY 2017
VL 31
IS 10
BP 1681
EP 1685
DI 10.1111/jdv.14187
PG 5
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA FK5ZM
UT WOS:000413582400045
PM 28252813
DA 2025-06-11
ER

PT J
AU Paruthiyil, S
   Hagiwara, S
   Kundassery, K
   Bhargava, A
AF Paruthiyil, Sreenivasan
   Hagiwara, Shin-ichiro
   Kundassery, Keshav
   Bhargava, Aditi
TI Sexually dimorphic metabolic responses mediated by CRF2
   receptor during nutritional stress in mice
SO BIOLOGY OF SEX DIFFERENCES
LA English
DT Article
DE Blood glucose; Dyslipidemia; Fat mass; Hepatic steatosis; Plasma insulin
ID CORTICOTROPIN-RELEASING-FACTOR; INSULIN-RESISTANCE; GLUCAGON-SECRETION;
   ENERGY-BALANCE; MESSENGER-RNA; EXPRESSION; HORMONE; MECHANISMS;
   INFLAMMATION; ISLETS
AB BackgroundChronic stress is a major contributor in the development of metabolic syndrome and associated diseases, such as diabetes. High-fat diet (HFD) and sex are known modifiers of metabolic parameters. Peptide hormones corticotropin-releasing factor (CRF) and urocortins (UCN) mediate stress responses via activation and feedback to the hypothalamic-pituitary-adrenal (HPA) axis. UCN3 is a marker of pancreatic -cell differentiation, and UCN2 is known to ameliorate glucose levels in mice rendered diabetic with HFD. CRF receptor 2 (CRF2) is the only known cognate receptor for UCN2/3. Here, we ascertained the role of CRF2 in glucose clearance, insulin sensitivity, and other parameters associated with metabolic syndrome in a mouse model of nutritional stress.MethodsWild-type (WT) and Crhr2(-/-) (null) mice of both sexes were fed either normal chow diet or HFD. After 8weeks, blood glucose levels in response to glucose and insulin challenge were determined. Change in body and fat mass, plasma insulin, and lipid profile were assessed. Histological evaluation of liver sections was performed.ResultsHere, we show that genotype (Crhr2), sex, and diet were all independent variables in the regulation of blood glucose levels, body and fat mass gain/redistribution, and insulin resistance. Surprisingly, CRF2-deficient mice (Crhr2(-/-)) male mice showed similarly impaired glucose clearance on HFD and chow. HFD-fed female Crhr2(-/-) mice redistributed their fat depots that were distinct from wild-type females and male mice on either diet. Blood cholesterol and low-density lipoprotein (LDL) levels were elevated significantly in male Crhr2(-/-) mice; female Crhr2(-/-) mice were protected. Male, but not female Crhr2(-/-) mice developed peripheral insulin resistance. HFD, but not chow-fed wild-type male mice developed hepatic macrovesicular steatosis. In contrast, livers of Crhr2(-/-) male mice showed microvesicular steatosis on either diet, whereas livers of female mice on this 8-week HFD regimen did not develop steatosis.ConclusionsCRF(2) receptor dysregulation is a sexually dimorphic risk factor in development of pre-diabetic and metabolic symptoms.
C1 [Bhargava, Aditi] Univ Calif San Francisco, Dept Obstet & Gynecol, Ctr Reprod Sci, 513 Parnassus Ave,HSE1645,Box 0556, San Francisco, CA 94143 USA.
   Univ Calif San Francisco, Osher Ctr Integrat Med, 513 Parnassus Ave,HSE1645,Box 0556, San Francisco, CA 94143 USA.
C3 University of California System; University of California San Francisco;
   University of California System; University of California San Francisco
RP Bhargava, A (corresponding author), Univ Calif San Francisco, Dept Obstet & Gynecol, Ctr Reprod Sci, 513 Parnassus Ave,HSE1645,Box 0556, San Francisco, CA 94143 USA.
EM Aditi.bhargava@ucsf.edu
OI Bhargava, Aditi/0000-0003-1334-0517; Kundassery,
   Keshav/0000-0002-1218-1940
FU NIH from UCSF Diabetes Center [P30-DK063720];  [DK R56-080787]
FX This work was funded in part by a NIH grant P30-DK063720 awarded as a
   pilot grant from UCSF Diabetes Center to AB and DK R56-080787 (AB).
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NR 43
TC 23
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U1 0
U2 5
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 2042-6410
J9 BIOL SEX DIFFER
JI Biol. Sex Differ.
PD NOV 6
PY 2018
VL 9
AR 49
DI 10.1186/s13293-018-0208-4
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WC Endocrinology & Metabolism; Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Genetics & Heredity
GA GZ4CD
UT WOS:000449339100001
PM 30400826
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Anderson, G
   Maes, M
AF Anderson, George
   Maes, Michael
TI Gut Dysbiosis Dysregulates Central and Systemic Homeostasis via
   Suboptimal Mitochondrial Function: Assessment, Treatment and
   Classification Implications
SO CURRENT TOPICS IN MEDICINAL CHEMISTRY
LA English
DT Review
DE Butyrate; Gut permeability; Microbiome; Mitochondria; Immune; Melatonin;
   Classification; Psychiatry; Treatment; Stress
ID CATABOLITE TRYCAT PATHWAY; NF-KAPPA-B; NITROSATIVE STRESS; TRYPTOPHAN
   CATABOLITE; PRENATAL STRESS; INFLAMMATORY RESPONSE; NICOTINIC RECEPTOR;
   MULTIPLE-SCLEROSIS; METABOLIC SYNDROME; MAJOR DEPRESSION
AB The gut and mitochondria have emerged as two important hubs at the cutting edge of research across a diverse array of medical conditions, including most psychiatric conditions. This article highlights the interaction of the gut and mitochondria over the course of development, with an emphasis on the consequences for transdiagnostic processes across psychiatry, but with relevance to wider medical conditions. As well as raised levels of circulating lipopolysaccharide (LPS) arising from increased gut permeability, the loss of the short-chain fatty acid, butyrate, is an important mediator of how gut dysbiosis modulates mitochondrial function. Reactive cells, central glia and systemic immune cells are also modulated by the gut, in part via impacts on mitochondrial function in these cells. Gut-driven alterations in the activity of reactive cells over the course of development are proposed to be an important determinant of the transdiagnostic influence of glia and the immune system. Stress, including prenatal stress, also acts via the gut. The suppression of butyrate, coupled to raised LPS, drives oxidative and nitrosative stress signalling that culminates in the activation of acidic sphingomyelinase-induced ceramide. Raised ceramide levels negatively regulate mitochondrial function, both directly and via its negative impact on daytime, arousal-promoting orexin and night-time sleep-promoting pineal gland-derived melatonin. Both orexin and melatonin positively regulate mitochondria oxidative phosphorylation. Consequently, gut-mediated increases in ceramide have impacts on the circadian rhythm and the circadian regulation of mitochondrial function. Butyrate, orexin and melatonin can positively regulate mitochondria via the disinhibition of the pyruvate dehydrogenase complex, leading to increased conversion of pyruvate to acetyl-CoA. Acetyl-CoA is a necessary co-substrate for the initiation of the melatonergic pathway in mitochondria and therefore the beneficial effects of mitochondria melatonin synthesis on mitochondrial function. This has a number of treatment implications across psychiatric and wider medical conditions, including the utilization of sodium butyrate and melatonin.
   Overall, gut dysbiosis and increased gut permeability have significant impacts on central and systemic homeostasis via the regulation of mitochondrial function, especially in central glia and systemic immune cells.
C1 [Anderson, George] CRC Scotland & London, Eccleston Sq, London, England.
   [Maes, Michael] Chulalongkorn Univ, Dept Psychiat, Bangkok, Thailand.
   [Maes, Michael] Deakin Univ, IMPACT Strateg Res Ctr, Geelong, Vic, Australia.
C3 Chulalongkorn University; Deakin University
RP Anderson, G (corresponding author), CRC Scotland & London, Eccleston Sq, London, England.
EM anderson.george@rocketmail.com
RI Maes, Michael/B-8546-2011; Anderson, George/AEO-3626-2022
OI Anderson, George/0000-0001-7243-0817
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PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
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GA LG7NU
UT WOS:000528283700004
PM 32003689
DA 2025-06-11
ER

PT J
AU Caruso, A
   Nicoletti, F
   Gaetano, A
   Scaccianoce, S
AF Caruso, Alessandra
   Nicoletti, Ferdinando
   Gaetano, Alessandra
   Scaccianoce, Sergio
TI Risk Factors for Alzheimer's Disease: Focus on Stress
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Review
DE stress; glucocorticoids; Alzheimer's disease; risk factor; animal model
ID EARLY-LIFE STRESS; AMYLOID-BETA; GLUCOCORTICOID-RECEPTOR; SYNAPTIC
   DYSFUNCTION; TAU-PROTEIN; HYPERPHOSPHORYLATED-TAU; MISSENSE MUTATIONS;
   COGNITIVE FUNCTION; MOUSE MODEL; BRAIN
AB In vulnerable individuals, chronic and persistent stress is an established risk factor for disorders that are comorbid with Alzheimer's disease (AD), such as hypertension, obesity and metabolic syndrome, and psychiatric disorders. There are no disease-modifying drugs in the treatment of AD, and all phase-3 clinical trials with anti-amyloid drugs (e.g., beta- or gamma-secretase inhibitors and monoclonal antibodies) did not meet the primary endpoints. There are many reasons for the lack of efficacy of anti-amyloid drugs in AD, the most likely being a late start of treatment, considering that pathophysiological mechanisms underlying synaptic dysfunction and neuronal death begin several decades before the clinical onset of AD. The identification of risk factors is, therefore, an essential step for early treatment of AD with candidate disease-modifying drugs. Preclinical studies suggest that stress, and the resulting activation of the hypothalamic-pituitary-adrenal axis, can induce biochemical abnormalities reminiscent to those found in autoptic brain samples from individuals affected by AD (e.g., increases amyloid precursor protein and tau hyperphosphorylation). In this review, we will critically analyze the current knowledge supporting stress as a potential risk factor for AD.
C1 [Caruso, Alessandra; Nicoletti, Ferdinando; Gaetano, Alessandra; Scaccianoce, Sergio] Sapienza Univ Roma, Dept Physiol & Pharmacol, Rome, Italy.
   [Nicoletti, Ferdinando] IRCCS Neuromed, Neuropharmacol Res Unit, Pozzilli, Italy.
C3 Sapienza University Rome; IRCCS Neuromed
RP Scaccianoce, S (corresponding author), Sapienza Univ Roma, Dept Physiol & Pharmacol, Rome, Italy.
EM sergio.scaccianoce@uniroma1.it
RI Nicoletti, Ferdinando/M-4428-2016
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NR 88
TC 20
Z9 20
U1 4
U2 26
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD SEP 10
PY 2019
VL 10
AR 976
DI 10.3389/fphar.2019.00976
PG 8
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Pharmacology & Pharmacy
GA IW7JT
UT WOS:000485165700002
PM 31551781
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Iwasaki, Y
   Suganami, T
   Hachiya, R
   Shirakawa, I
   Kim-Saijo, M
   Tanaka, M
   Hamaguchi, M
   Takai-Igarashi, T
   Nakai, M
   Miyamoto, Y
   Ogawa, Y
AF Iwasaki, Yorihiro
   Suganami, Takayoshi
   Hachiya, Rumi
   Shirakawa, Ibuki
   Kim-Saijo, Misa
   Tanaka, Miyako
   Hamaguchi, Miho
   Takai-Igarashi, Takako
   Nakai, Michikazu
   Miyamoto, Yoshihiro
   Ogawa, Yoshihiro
TI Activating Transcription Factor 4 Links Metabolic Stress to
   Interleukin-6 Expression in Macrophages
SO DIABETES
LA English
DT Article
ID ENDOPLASMIC-RETICULUM STRESS; UNFOLDED PROTEIN RESPONSE; NF-KAPPA-B;
   INTERACTION NETWORKS; INFLAMMATORY CHANGES; INSULIN-RESISTANCE;
   FATTY-ACIDS; MOUSE MODEL; ER STRESS; HOMEOSTASIS
AB Chronic inflammation is a molecular element of the metabolic syndrome and type 2 diabetes. Saturated fatty acids (SFAs) are considered to be an important proinflammatory factor. However, it is still incompletely understood how SFAs induce proinflammatory cytokine expression. Hereby we report that activating transcription factor (ATF) 4, a transcription factor that is induced downstream of metabolic stresses including endoplasmic reticulum (ER) stress, plays critical roles in SFA-induced interleukin-6 (Il6) expression. DNA microarray analysis using primary macrophages revealed that the ATF4 pathway is activated by SFAs. Haploinsufficiency and short hairpin RNA-based knockdown of ATF4 in macrophages markedly inhibited SFA- and metabolic stress-induced Il6 expression. Conversely, pharmacological activation of the ATF4 pathway and overexpression of ATF4 resulted in enhanced Il6 expression. Moreover, ATF4 acts in synergy with the Toll-like receptor-4 signaling pathway, which is known to be activated by SFAs. At a molecular level, we found that ATF4 exerts its proinflammatory effects through at least two different mechanisms: ATF4 is involved in SFA-induced nuclear factor-B activation; and ATF4 directly activates the Il6 promoter. These findings provide evidence suggesting that ATF4 links metabolic stress and Il6 expression in macrophages.
C1 [Iwasaki, Yorihiro; Hachiya, Rumi; Kim-Saijo, Misa; Tanaka, Miyako; Hamaguchi, Miho; Ogawa, Yoshihiro] Tokyo Med & Dent Univ, Dept Mol Endocrinol & Metab, Grad Sch Med & Dent Sci, Tokyo, Japan.
   [Suganami, Takayoshi; Shirakawa, Ibuki] Tokyo Med & Dent Univ, Dept Organ Network & Metab, Grad Sch Med & Dent Sci, Tokyo, Japan.
   [Ogawa, Yoshihiro] Tokyo Med & Dent Univ, Global Ctr Excellence Program, Int Res Ctr Mol Sci Tooth & Bone Dis, Tokyo, Japan.
   [Iwasaki, Yorihiro] Tazuke Kofukai Med Res Inst, Ctr Diabet & Endocrinol, Osaka, Japan.
   [Takai-Igarashi, Takako] Tohoku Univ, Dept Hlth Record Informat, Tohoku Med Megabank Org, Sendai, Miyagi 980, Japan.
   [Nakai, Michikazu; Miyamoto, Yoshihiro] Natl Cerebral & Cardiovasc Ctr, Dept Prevent Med & Epidemiol Informat, Osaka, Japan.
   [Miyamoto, Yoshihiro] Natl Cerebral & Cardiovasc Ctr, Dept Prevent Cardiol, Osaka, Japan.
   [Suganami, Takayoshi] Japan Sci & Technol Agcy, Precursory Res Embryon Sci & Technol, Tokyo 1028666, Japan.
   [Hachiya, Rumi] Japan Soc Promot Sci Young Sci, Tokyo, Japan.
C3 Institute of Science Tokyo; Tokyo Medical & Dental University (TMDU);
   Institute of Science Tokyo; Tokyo Medical & Dental University (TMDU);
   Institute of Science Tokyo; Tokyo Medical & Dental University (TMDU);
   Tohoku University; National Cerebral & Cardiovascular Center - Japan;
   National Cerebral & Cardiovascular Center - Japan; Japan Science &
   Technology Agency (JST); Japan Society for the Promotion of Science
RP Suganami, T (corresponding author), Tokyo Med & Dent Univ, Dept Organ Network & Metab, Grad Sch Med & Dent Sci, Tokyo, Japan.
EM suganami.mem@tmd.ac.jp; ogawa.mem@tmd.ac.jp
RI Hachiya, Rumi/ABF-5457-2021; Iwasaki, Yorihiro/HJI-2969-2023; SUGANAMI,
   Takayoshi/A-9475-2016; Nakai, Michikazu/ADJ-0980-2022; Tanaka,
   Miyako/B-2805-2016
OI Suganami, Takayoshi/0000-0002-1918-0465; xing zhi, shi
   zhi/0000-0003-3289-5681; Hachiya, Rumi/0000-0001-8412-3494; Ogawa,
   Yoshihiro/0000-0002-0834-2836; Iwasaki, Yorihiro/0000-0001-9787-7922
FU Ministry of Education, Culture, Sports, Science and Technology of Japan;
   Japan Science and Technology Agency, Precursory Research for Embryonic
   Science and Technology; Astellas Foundation for Research on Metabolic
   Disorders; Nestle Nutrition Council, Japan; Grants-in-Aid for Scientific
   Research [25670407, 24790942, 21117007] Funding Source: KAKEN
FX This work was supported in part by Grants-in-Aid for Scientific Research
   from the Ministry of Education, Culture, Sports, Science and Technology
   of Japan; Japan Science and Technology Agency, Precursory Research for
   Embryonic Science and Technology; Astellas Foundation for Research on
   Metabolic Disorders; and Nestle Nutrition Council, Japan.
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NR 36
TC 101
Z9 107
U1 1
U2 13
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0012-1797
EI 1939-327X
J9 DIABETES
JI Diabetes
PD JAN
PY 2014
VL 63
IS 1
BP 152
EP 161
DI 10.2337/db13-0757
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 275MF
UT WOS:000328680400023
PM 23990363
OA hybrid
DA 2025-06-11
ER

PT J
AU Rajagopalan, K
   Meyer, K
   O'Day, K
   Denno, M
   Loebel, A
AF Rajagopalan, Krithika
   Meyer, Kellie
   O'Day, Ken
   Denno, Melissa
   Loebel, Antony
TI Cost-effectiveness of lurasidone vs quetiapine extended-release (XR) in
   patients with bipolar depression
SO JOURNAL OF MEDICAL ECONOMICS
LA English
DT Article
DE Cost-effectiveness; Lurasidone; Bipolar I depression; Quetiapine XR
ID WEEKLY SYMPTOMATIC STATUS; MAINTENANCE TREATMENT; METABOLIC SYNDROME;
   MOOD STABILIZERS; NATURAL-HISTORY; DISORDER; HEALTH; PREVALENCE;
   LIFETIME; BURDEN
AB Objective:
   Bipolar disorder imposes a high economic burden on patients and society. Lurasidone and quetiapine extended-release (XR) are atypical antipsychotic agents indicated for monotherapy treatment of bipolar depression. Lurasidone is also indicated as adjunctive therapy with lithium or valproate for depressive episodes associated with bipolar disorder. The objective of this analysis was to estimate the cost-effectiveness of lurasidone and quetiapine XR in patients with bipolar depression.
   Methods:
   A cost-effectiveness model was developed to compare lurasidone to quetiapine XR. The model was based on a US third-party payer perspective over a 3-month time horizon. The effectiveness measure in the model was the percentage of patients achieving remission (Montgomery-Asberg Depression Rating Scale [MADRS] total score <= 12 by weeks 6-8). The comparison of remission rates was made through an adjusted indirect treatment comparison of lurasidone and quetiapine XR pivotal trials using placebo as the common comparator. Resource utilization for remission vs no remission was estimated from published expert panel data, and resource costs were obtained from a retrospective database study of bipolar I depression patients. Drug costs were estimated using the mean dose from clinical trials and wholesale acquisition costs.
   Results:
   Over the 3-month model time period, lurasidone and quetiapine XR patients, respectively, had similar mean numbers of emergency department visits (0.48 vs 0.50), inpatient days (2.1 vs 2.2), and office visits (9.3 vs 9.6). More lurasidone than quetiapine XR patients achieved remission (52.0% vs 43.2%) with slightly higher total costs ($4982 vs $4676), resulting in an incremental cost-effectiveness ratio of $3474 per remission. The probabilistic sensitivity analysis showed lurasidone had an 86% probability of being cost-effective compared to quetiapine XR at a willingness-to-pay threshold of $10,000 per remission.
   Conclusions:
   Lurasidone may be a cost-effective option when compared to quetiapine XR for the treatment of adults with bipolar depression.
C1 [Rajagopalan, Krithika; Loebel, Antony] Sunovion Pharmaceut Inc, Marlborough, MA USA.
   [Meyer, Kellie; O'Day, Ken; Denno, Melissa] Xcenda LLC, Palm Harbor, FL USA.
C3 Dainippon Sumitomo Pharmaceutical Company; Sunovion Pharmaceuticals
   Inc.; AmerisourceBergen Corporation; Xcenda, LLC
RP Rajagopalan, K (corresponding author), Sunovion Pharmaceut Inc, Marlborough, MA USA.
EM Krithika.Rajagopalan@sunovion.com
OI Rajagopalan, Krithika/0000-0002-4878-0822
FU Sunovion Pharmaceuticals Inc.
FX This manuscript was sponsored by Sunovion Pharmaceuticals Inc.
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NR 33
TC 5
Z9 5
U1 0
U2 2
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1369-6998
EI 1941-837X
J9 J MED ECON
JI J. Med. Econ.
PY 2015
VL 18
IS 10
BP 821
EP 827
DI 10.3111/13696998.2015.1052462
PG 7
WC Economics; Health Care Sciences & Services; Health Policy & Services;
   Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Business & Economics; Health Care Sciences & Services; General &
   Internal Medicine
GA DD5OL
UT WOS:000369973500007
PM 25985265
DA 2025-06-11
ER

PT J
AU Lu, HJ
   Koju, N
   Sheng, R
AF Lu, Hao-jun
   Koju, Nirmala
   Sheng, Rui
TI Mammalian integrated stress responses in stressed organelles and their
   functions
SO ACTA PHARMACOLOGICA SINICA
LA English
DT Review
DE integrated stress response; organelles; eukaryotic translation
   initiation factor 2; activating transcription factor 4; protein
   homeostasis
ID UNFOLDED-PROTEIN-RESPONSE; ENDOPLASMIC-RETICULUM STRESS;
   RESPIRATORY-CHAIN SUPERCOMPLEXES; ISCHEMIA-REPERFUSION INJURY;
   INITIATION-FACTOR 2B; ER-STRESS; IN-VITRO; EIF2-ALPHA DEPHOSPHORYLATION;
   NUCLEOTIDE EXCHANGE; QUALITY CONTROL
AB The integrated stress response (ISR) triggered in response to various cellular stress enables mammalian cells to effectively cope with diverse stressful conditions while maintaining their normal functions. Four kinases (PERK, PKR, GCN2, and HRI) of ISR regulate ISR signaling and intracellular protein translation via mediating the phosphorylation of eukaryotic translation initiation factor 2 alpha (eIF2 alpha) at Ser51. Early ISR creates an opportunity for cells to repair themselves and restore homeostasis. This effect, however, is reversed in the late stages of ISR. Currently, some studies have shown the non-negligible impact of ISR on diseases such as ischemic diseases, cognitive impairment, metabolic syndrome, cancer, vanishing white matter, etc. Hence, artificial regulation of ISR and its signaling with ISR modulators becomes a promising therapeutic strategy for relieving disease symptoms and improving clinical outcomes. Here, we provide an overview of the essential mechanisms of ISR and describe the ISR-related pathways in organelles including mitochondria, endoplasmic reticulum, Golgi apparatus, and lysosomes. Meanwhile, the regulatory effects of ISR modulators and their potential application in various diseases are also enumerated.
C1 [Lu, Hao-jun; Koju, Nirmala; Sheng, Rui] Soochow Univ, Coll Pharmaceut Sci, Jiangsu Key Lab Neuropsychiat Dis, Dept Pharmacol, Suzhou 215123, Peoples R China.
   [Lu, Hao-jun; Koju, Nirmala; Sheng, Rui] Soochow Univ, Coll Pharmaceut Sci, Lab Aging & Nervous Dis, Jiangsu Key Lab Neuropsychiat Dis, Suzhou 215123, Peoples R China.
C3 Soochow University - China; Soochow University - China
RP Sheng, R (corresponding author), Soochow Univ, Coll Pharmaceut Sci, Jiangsu Key Lab Neuropsychiat Dis, Dept Pharmacol, Suzhou 215123, Peoples R China.; Sheng, R (corresponding author), Soochow Univ, Coll Pharmaceut Sci, Lab Aging & Nervous Dis, Jiangsu Key Lab Neuropsychiat Dis, Suzhou 215123, Peoples R China.
EM sheng_rui@163.com
RI Sheng, Rui/N-5436-2017
FU National Natural Science Foundation of China [82173811, 81973315];
   Jiangsu Key Laboratory of Neuropsychiatric Diseases [BM2013003];
   Priority Academic Program Development of the Jiangsu Higher Education
   Institutes (PAPD); Suzhou International Joint Laboratory for Diagnosis
   and Treatment of Brain Diseases
FX This work was supported by grants from the National Natural Science
   Foundation of China (No. 82173811, 81973315), Jiangsu Key Laboratory of
   Neuropsychiatric Diseases (BM2013003), Priority Academic Program
   Development of the Jiangsu Higher Education Institutes (PAPD) and Suzhou
   International Joint Laboratory for Diagnosis and Treatment of Brain
   Diseases.
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NR 312
TC 15
Z9 16
U1 12
U2 41
PU NATURE PUBL GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1671-4083
EI 1745-7254
J9 ACTA PHARMACOL SIN
JI Acta Pharmacol. Sin.
PD JUN
PY 2024
VL 45
IS 6
BP 1095
EP 1114
DI 10.1038/s41401-023-01225-0
EA JAN 2024
PG 20
WC Chemistry, Multidisciplinary; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Pharmacology & Pharmacy
GA SK6P7
UT WOS:001147845900002
PM 38267546
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Quetglas-Llabrés, MM
   Monserrat-Mesquida, M
   Bouzas, C
   García, S
   Mateos, D
   Ugarriza, L
   Gómez, C
   Sureda, A
   Tur, JA
AF Quetglas-Llabres, Maria Magdalena
   Monserrat-Mesquida, Margalida
   Bouzas, Cristina
   Garcia, Silvia
   Mateos, David
   Ugarriza, Lucia
   Gomez, Cristina
   Sureda, Antoni
   Tur, Josep A.
TI Long-Term Impact of Nutritional Intervention with Increased Polyphenol
   Intake and Physical Activity Promotion on Oxidative and Inflammatory
   Profiles in Patients with Metabolic Syndrome
SO NUTRIENTS
LA English
DT Article
DE obesity; cardiovascular disease; intervention; oxidative stress;
   inflammation
ID WEIGHT-LOSS; CARDIOVASCULAR-DISEASE; ADIPOSE-TISSUE; OBESITY; STRESS;
   MANAGEMENT; MYELOPEROXIDASE; QUESTIONNAIRE; METAANALYSIS; ASSOCIATION
AB Obesity and overweight pose significant risks to health, contributing to the prevalence of chronic conditions like type 2 diabetes mellitus (T2DM) and cardiovascular diseases (CVD). The current study aimed to assess the impact of a 6-year nutritional and lifestyle intervention on oxidative and inflammatory markers in individuals aged 55 to 75, specifically those at high risk of CVD. A study was carried out in a group of 80 participants with metabolic syndrome (MetS) residing in Mallorca, Spain, who underwent nutritional intervention based on a low-calorie Mediterranean diet (MedDiet) and promotion of physical activity. Before and after the intervention, several parameters including anthropometric data, haematological factors, blood pressure, and physical activity level were measured. Oxidative and inflammatory biomarkers in plasma were analysed. After the 6-year intervention, participants who managed to reduce their body mass index (BMI) had greater reductions in abdominal obesity, waist to heigh ratio (WHtR), diastolic blood pressure, and glucose levels, and increased high density protein cholesterol (HDL-c) compared to those who did not reduce BMI. This higher reduction in BMI was related to reduced energy intake and increased adherence to MedDiet, with greater polyphenol intake, and total physical activity (PA). Furthermore, improvements in oxidative stress and proinflammatory status were observed in participants who reduced their BMI. Significant reductions in the activity of the prooxidant enzyme, myeloperoxidase (MPO), levels of the lipid oxidation marker, malondialdehyde (MDA), and the proinflammatory chemokine, monocyte chemoattractant protein-1 (MCP-1,) were found in those who reduced their BMI. In contrast, participants who did not improve their BMI exhibited higher levels of proinflammatory markers such as MCP-1 and tumour necrosis factor alpha (TNF alpha), as well as increased activity of the antioxidant enzyme catalase (CAT). Current findings suggest that an effective way to reduce BMI is a hypocaloric MedDiet combined with tailored physical activity to improve oxidative stress and proinflammatory status, and potentially reducing the risk of CVD.
C1 [Quetglas-Llabres, Maria Magdalena; Monserrat-Mesquida, Margalida; Bouzas, Cristina; Garcia, Silvia; Mateos, David; Ugarriza, Lucia; Gomez, Cristina; Sureda, Antoni; Tur, Josep A.] Univ Balear Isl IUNICS, Res Grp Community Nutr & Oxidat Stress, Palma De Mallorca 07122, Spain.
   [Quetglas-Llabres, Maria Magdalena; Monserrat-Mesquida, Margalida; Bouzas, Cristina; Garcia, Silvia; Mateos, David; Ugarriza, Lucia; Gomez, Cristina; Sureda, Antoni; Tur, Josep A.] Hlth Res Inst Balear Isl IdISBa, Palma De Mallorca 07120, Spain.
   [Quetglas-Llabres, Maria Magdalena; Monserrat-Mesquida, Margalida; Bouzas, Cristina; Garcia, Silvia; Mateos, David; Ugarriza, Lucia; Sureda, Antoni; Tur, Josep A.] Inst Salud Carlos III, Physiopathol Obes & Nutr CIBEROBN, Madrid 28029, Spain.
   [Gomez, Cristina] Univ Hosp Son Espases, Clin Anal Serv, Palma De Mallorca 07198, Spain.
C3 Institut Investigacio Sanitaria Illes Balears (IdISBa); Instituto de
   Salud Carlos III; CIBER - Centro de Investigacion Biomedica en Red;
   CIBEROBN; Hospital Universitari Son Espases
RP Sureda, A (corresponding author), Univ Balear Isl IUNICS, Res Grp Community Nutr & Oxidat Stress, Palma De Mallorca 07122, Spain.; Sureda, A (corresponding author), Hlth Res Inst Balear Isl IdISBa, Palma De Mallorca 07120, Spain.; Sureda, A (corresponding author), Inst Salud Carlos III, Physiopathol Obes & Nutr CIBEROBN, Madrid 28029, Spain.
EM margalida.monserrat@uib.es; antoni.sureda@uib.es; pep.tur@uib.es
RI Bouzas, Cristina/AAE-2069-2019; Quetglas Llabrés, Maria/AAA-4412-2019;
   Tur, Josep/AAE-5748-2020; Mesquida, Margalida/AAB-4773-2019; Sureda,
   Antoni/N-9588-2019; Tur, Josep/F-5576-2014
OI Tur, Josep/0000-0002-6940-0761; Bouzas Velasco,
   Cristina/0000-0002-1407-8461; Monserrat Mesquida,
   Margalida/0000-0002-8856-135X; Garcia, Silvia/0000-0003-3534-1588;
   Quetglas Llabres, Maria Magdalena/0000-0003-4155-7780; ,
   Antoni/0000-0001-8656-6838; GOMEZ COBO, CRISTINA/0000-0002-9776-4730
FU Government of Balearic Islands, Direccio General de Politica
   Universitaria i Recerca [AP_2021_030]; IDISBA grant; SOIB-Investigo
   Program; Juan de la Cierva Program (Ministry of Science and Innovation,
   Spain; Margalida Comas Program (DG R+D+I, Balearic Islands Government,
   Spain); CIBER Fisiopatologia de la Obesidad y Nutricion (CIBEROBN)
   [CB12/03/30038]; Instituto de Salud Carlos III (ISCIII), through the
   Fondo de Investigacion para la Salud [FISP I20/00456]; European Regional
   Development Fund
FX This work was supported by the official Spanish Institutions for funding
   scientific biomedical research, CIBER Fisiopatologia de la Obesidad y
   Nutricion (CIBEROBN CB12/03/30038) and Instituto de Salud Carlos III
   (ISCIII), through the Fondo de Investigacion para la Salud (project FISP
   I20/00456), which is co-funded by the European Regional Development
   Fund. The work was also supported by the Government of Balearic Islands,
   Direccio General de Politica Universitaria i Recerca (AP_2021_030).
   M.M.Q.-L. was granted by IDISBA grant. M.M.M. and S.G. were granted by
   SOIB-Investigo Program. C.B. was granted by Juan de la Cierva Program
   (Ministry of Science and Innovation, Spain, and Margalida Comas Program
   (DG R+D+I, Balearic Islands Government, Spain). The funding sponsors had
   no role in the design of the study, in the collection, analyses, or
   interpretation of the data; in the writing of the manuscript, or in the
   decision to publish the results.
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NR 61
TC 2
Z9 2
U1 1
U2 7
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JUL
PY 2024
VL 16
IS 13
AR 2121
DI 10.3390/nu16132121
PG 18
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA YN6V9
UT WOS:001269215900001
PM 38999869
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Sodhi, K
   Puri, N
   Favero, G
   Stevens, S
   Meadows, C
   Abraham, NG
   Rezzani, R
   Ansinelli, H
   Lebovics, E
   Shapiro, JI
AF Sodhi, Komal
   Puri, Nitin
   Favero, Gaia
   Stevens, Sarah
   Meadows, Charles
   Abraham, Nader G.
   Rezzani, Rita
   Ansinelli, Hayden
   Lebovics, Edward
   Shapiro, Joseph I.
TI RETRACTED: Fructose Mediated Non-Alcoholic Fatty Liver Is Attenuated by
   HO-1-SIRT1 Module in Murine Hepatocytes and Mice Fed a High Fructose
   Diet (Retracted Article)
SO PLOS ONE
LA English
DT Article; Retracted Publication
ID IMPROVES INSULIN SENSITIVITY; MESENCHYMAL STEM-CELLS; HEPATIC STELLATE
   CELLS; HEME OXYGENASE; METABOLIC SYNDROME; CARDIOVASCULAR-DISEASE;
   VASCULAR DYSFUNCTION; LIPID-PEROXIDATION; PROTECTIVE ROLE;
   ADIPOSE-TISSUE
AB Background
   Oxidative stress underlies the etiopathogenesis of nonalcoholic fatty liver disease (NAFLD), obesity and cardiovascular disease (CVD). Heme Oxygenase-1 (HO-1) is a potent endogenous antioxidant gene that plays a key role in decreasing oxidative stress. Sirtuin1 (SIRT1) belongs to the family of NAD-dependent de-acyetylases and is modulated by cellular redox.
   Hypothesis
   We hypothesize that fructose-induced obesity creates an inflammatory and oxidative environment conducive to the development of NAFLD and metabolic syndrome. The aim of this study is to determine whether HO-1 acts through SIRT1 to form a functional module within hepatocytes to attenuate steatohepatitis, hepatic fibrosis and cardiovascular dysfunction.
   Methods and Results
   We examined the effect of fructose, on hepatocyte lipid accumulation and fibrosis in murine hepatocytes and in mice fed a high fructose diet in the presence and absence of CoPP, an inducer of HO-1, and SnMP, an inhibitor of HO activity. Fructose increased oxidative stress markers and decreased HO-1 and SIRT1 levels in hepatocytes (p<0.05). Further fructose supplementation increased FAS, PPARa, pAMPK and triglycerides levels; CoPP negated this increase. Concurrent treatment with CoPP and SIRT1 siRNA in hepatocytes increased FAS, PPARa, pAMPK and triglycerides levels suggesting that HO-1 is upstream of SIRT1 and suppression of SIRT1 attenuates the beneficial effects of HO-1. A high fructose diet increased insulin resistance, blood pressure, markers of oxidative stress and lipogenesis along with fibrotic markers in mice (p<0.05). Increased levels of HO-1 increased SIRT1 levels and ameliorated fructose-mediated lipid accumulation and fibrosis in liver along with decreasing vascular dysfunction (p<0.05 vs. fructose). These beneficial effects of CoPP were reversed by SnMP.
   Conclusion
   Taken together, our study demonstrates, for the first time, that HO-1 induction attenuates fructose-induced hepatic lipid deposition, prevents the development of hepatic fibrosis and abates NAFLD-associated vascular dysfunction; effects that are mediated by activation of SIRT1 gene expression.
C1 [Sodhi, Komal; Stevens, Sarah; Meadows, Charles; Ansinelli, Hayden; Shapiro, Joseph I.] Marshall Univ, Joan C Edwards Sch Med, Dept Med, Huntington, WV 25701 USA.
   [Sodhi, Komal; Stevens, Sarah; Meadows, Charles; Ansinelli, Hayden; Shapiro, Joseph I.] Marshall Univ, Joan C Edwards Sch Med, Dept Surg, Huntington, WV USA.
   [Puri, Nitin] Univ Toledo, Coll Med, Dept Physiol & Pharmacol, Toledo, OH 43606 USA.
   [Favero, Gaia; Rezzani, Rita] Univ Brescia, Dept Clin & Expt Sci, Div Anat & Physiopathol, Brescia, Italy.
   [Abraham, Nader G.; Lebovics, Edward] New York Med Coll, Dept Med, Valhalla, NY 10595 USA.
   [Abraham, Nader G.; Lebovics, Edward] New York Med Coll, Dept Gastroenterol, Valhalla, NY 10595 USA.
C3 Marshall University; Marshall University; University System of Ohio;
   University of Toledo; University of Brescia; New York Medical College;
   New York Medical College
RP Sodhi, K (corresponding author), Marshall Univ, Joan C Edwards Sch Med, Dept Med, Huntington, WV 25701 USA.
EM Sodhi@marshall.edu
FU National Institutes of Health [NIH-1RO1HL109015-01]; Marshall University
FX Dr. Shapiro provided the funds to accomplish this study. Funds were
   taken from National Institutes of Health grant NIH-1RO1HL109015-01. The
   funding institution was Marshall University. Author who received funding
   is JS.
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NR 64
TC 61
Z9 63
U1 0
U2 18
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JUN 22
PY 2015
VL 10
IS 6
AR e0128648
DI 10.1371/journal.pone.0128648
PG 22
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA CL3FM
UT WOS:000356835800018
PM 26098879
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Su, Y
   Yu, H
   Wang, ZR
   Liu, S
   Zhao, LS
   Fu, YM
   Yang, YF
   Du, B
   Zhang, FQ
   Zhang, XR
   Huang, ML
   Hou, CL
   Huang, GP
   Su, ZH
   Peng, M
   Yan, R
   Zhang, YY
   Yan, H
   Wang, LF
   Lu, TL
   Jia, FJ
   Li, KQ
   Lv, LX
   Wang, HX
   Yu, SY
   Wang, Q
   Tan, YL
   Xu, Y
   Zhang, D
   Yue, WH
AF Su, Yi
   Yu, Hao
   Wang, Zhiren
   Liu, Sha
   Zhao, Liansheng
   Fu, Yingmei
   Yang, Yongfeng
   Du, Bo
   Zhang, Fuquan
   Zhang, Xiangrong
   Huang, Manli
   Hou, Cailan
   Huang, Guoping
   Su, Zhonghua
   Peng, Mao
   Yan, Ran
   Zhang, Yuyanan
   Yan, Hao
   Wang, Lifang
   Lu, Tianlan
   Jia, Fujun
   Li, Keqing
   Lv, Luxian
   Wang, Hongxing
   Yu, Shunying
   Wang, Qiang
   Tan, Yunlong
   Xu, Yong
   Zhang, Dai
   Yue, Weihua
TI Protocol for a pharmacogenomic study on individualised antipsychotic
   drug treatment for patients with schizophrenia
SO BJPSYCH OPEN
LA English
DT Article
DE Antipsychotics; clinical trial; schizophrenia; drug interactions and
   side-effects; genetics
ID RATING-SCALE; ASSOCIATION; CLOZAPINE; POLYMORPHISMS; DEFINITION;
   CONCORDANT; ABCB1
AB Background Schizophrenia is a severe and complex psychiatric disorder that needs treatment based on extensive experience. Antipsychotic drugs have already become the cornerstone of the treatment for schizophrenia; however, the therapeutic effect is of significant variability among patients, and only around a third of patients with schizophrenia show good efficacy. Meanwhile, drug-induced metabolic syndrome and other side-effects significantly affect treatment adherence and prognosis. Therefore, strategies for drug selection are desperately needed. In this study, we will perform pharmacogenomics research and set up an individualised preferred treatment prediction model. Aims We aim to create a standard clinical cohort, with multidimensional index assessment of antipsychotic treatment for patients with schizophrenia. Method This trial is designed as a randomised clinical trial comparing treatment with different kinds of antipsychotics. A total sample of 2000 patients with schizophrenia will be recruited from in-patient units from five clinical research centres. Using a computer-generated program, the participants will be randomly assigned to four treatment groups: aripiprazole, olanzapine, quetiapine and risperidone. The primary outcomes will be measured as changes in the Positive and Negative Syndrome Scale of schizophrenia, which reflects the efficacy. Secondary outcomes include the measure of side-effects, such as metabolic syndromes. The efficacy evaluation and side-effects assessment will be performed at baseline, 2 weeks, 6 weeks and 3 months. Results This trial will assess the efficacy and side effects of antipsychotics and create a standard clinical cohort with a multi-dimensional index assessment of antipsychotic treatment for schizophrenia patients. Conclusion This study aims to set up an individualized preferred treatment prediction model through the genetic analysis of patients using different kinds of antipsychotics.
C1 [Su, Yi; Yu, Hao; Zhang, Yuyanan; Yan, Hao; Wang, Lifang; Lu, Tianlan; Zhang, Dai; Yue, Weihua] Peking Univ, Inst Mental Hlth, Hosp 6, Beijing, Peoples R China.
   [Su, Yi; Yu, Hao; Zhang, Yuyanan; Yan, Hao; Wang, Lifang; Lu, Tianlan; Zhang, Dai; Yue, Weihua] Peking Univ, Key Lab Mental Hlth, Minist Hlth, Beijing, Peoples R China.
   [Su, Yi; Yu, Hao; Zhang, Yuyanan; Yan, Hao; Wang, Lifang; Lu, Tianlan; Zhang, Dai; Yue, Weihua] Peking Univ, Natl Clin Res Ctr Mental Disorders, Beijing, Peoples R China.
   [Yu, Hao] Jining Med Univ, Dept Psychiat, Jining, Peoples R China.
   [Wang, Zhiren] Peking Univ, Beijing HuiLongGuan Hosp, Psychiat Res Ctr, Beijing, Peoples R China.
   [Liu, Sha; Xu, Yong] Shanxi Med Univ, Dept Psychiat, Hosp 1, Clin Med Coll 1, Taiyuan, Peoples R China.
   [Zhao, Liansheng; Wang, Qiang] Sichuan Univ, West China Hosp, Mental Hlth Ctr, Chengdu, Peoples R China.
   [Fu, Yingmei; Yu, Shunying] Shanghai Jiao Tong Univ, Shanghai Mental Hlth Ctr, Shanghai, Peoples R China.
   [Yang, Yongfeng; Lv, Luxian] Xinxiang Med Univ, Henan Mental Hosp, Affiliated Hosp 2, Xinxiang, Henan, Peoples R China.
   [Du, Bo; Li, Keqing] Sixth Peoples Hosp Hebei Prov, Hebei Mental Hlth Ctr, Baoding, Peoples R China.
   [Zhang, Fuquan] Nanjing Med Univ, Wuxi Mental Hlth Ctr, Nanjing, Peoples R China.
   [Zhang, Xiangrong] Nanjing Med Univ, Nanjing Brain Hosp, Dept Geriatr Psychiat, Nanjing, Peoples R China.
   [Huang, Manli] Zhejiang Univ, Sch Med, Dept Psychiat, Affiliated Hosp 1, Hangzhou, Peoples R China.
   [Huang, Manli] Key Lab Mental Disorders Management Zhejiang Prov, Hangzhou, Peoples R China.
   [Hou, Cailan] Guangdong Acad Med Sci, Guangdong Prov Peoples Hosp, Guangdong Mental Hlth Ctr, Guangzhou, Guangdong, Peoples R China.
   [Hou, Cailan; Jia, Fujun] South China Univ Technol, Sch Med, Guangzhou, Guangdong, Peoples R China.
   [Huang, Guoping] Mental Hlth Ctr Sichuan Prov, Dept Psychiat, Chengdu, Peoples R China.
   [Su, Zhonghua] Jining Mental Hosp, Dept Psychiat, Jining, Peoples R China.
   [Peng, Mao; Wang, Hongxing] Capital Med Univ, Xuanwu Hosp, Dept Neurol, Beijing, Peoples R China.
   [Yan, Ran] Minist Hlth PRC, Dept Radiol, China Japan Friendship Hosp, Beijing, Peoples R China.
   [Jia, Fujun] Guangdong Gen Hosp, Guangdong Mental Hlth Ctr, Guangzhou, Peoples R China.
   [Tan, Yunlong] Peking Univ, Beijing HuiLongGuan Hosp, HuiLongGuan Clin Med Sch, Beijing, Peoples R China.
   [Zhang, Dai] Peking Univ, Peking Tsinghua Joint Ctr Life Sci, IDG McGovern Inst Brain Res, Beijing, Peoples R China.
C3 Peking University; Peking University; Peking University; Jining Medical
   University; Peking University; Shanxi Medical University; Sichuan
   University; Shanghai Jiao Tong University; Xinxiang Medical University;
   Nanjing Medical University; Nanjing Medical University; Zhejiang
   University; Guangdong Academy of Medical Sciences & Guangdong General
   Hospital; Southern Medical University - China; South China University of
   Technology; Capital Medical University; China-Japan Friendship Hospital;
   Guangdong Academy of Medical Sciences & Guangdong General Hospital;
   Peking University; Peking University
RP Yue, WH (corresponding author), Peking Univ, Inst Mental Hlth, Hosp 6, Beijing, Peoples R China.; Yue, WH (corresponding author), Peking Univ, Key Lab Mental Hlth, Minist Hlth, Beijing, Peoples R China.; Yue, WH (corresponding author), Peking Univ, Natl Clin Res Ctr Mental Disorders, Beijing, Peoples R China.
EM dryue@bjmu.edu.cn
RI , 复之-王红星/ABF-3671-2020; meng, yan/GSE-2653-2022; Zhang,
   Yuyanan/ISR-9977-2023; Zhang, Fengyu/M-1396-2019; Yang,
   Yongfeng/I-7680-2016; She, Zhi-Gang/AFP-9194-2022; Fu,
   Yingmei/AAN-1675-2021; Liu, Feng-Liang/O-4000-2019; qianglong,
   wang/HIK-3742-2022; Yu, Hao/GYD-8698-2022; Zhang, Deng-Feng/K-1125-2015;
   Yan, Hao/U-1330-2017; Su, Yi/ISU-4977-2023
OI Yu, Hao/0000-0002-9785-8489; Zhang, Fuquan/0000-0003-3204-8191; Su,
   Yi/0000-0003-0067-7313
FU Chinese Ministry of Science and Technology [2016YFC1307000]
FX This work is supported by a grant to Weihua Yue on behalf of the whole
   projectfrom the Chinese Ministry of Science and Technology (grant number
   2016YFC1307000).
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NR 34
TC 6
Z9 6
U1 1
U2 12
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 2056-4724
J9 BJPSYCH OPEN
JI BJPsych Open
PD JUN 29
PY 2021
VL 7
IS 4
AR e121
DI 10.1192/bjo.2021.945
PG 6
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA TB1JH
UT WOS:000667698900001
PM 34183088
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Che, LQ
   Xuan, Y
   Hu, L
   Liu, Y
   Xu, Q
   Fang, ZF
   Lin, Y
   Xu, SY
   Wu, D
   Zhang, KY
   Chen, DW
AF Che, Lianqiang
   Xuan, Yue
   Hu, Liang
   Liu, Yan
   Xu, Qin
   Fang, Zhengfeng
   Lin, Yan
   Xu, Shengyu
   Wu, De
   Zhang, Keying
   Chen, Daiwen
TI Effect of Postnatal Nutrition Restriction on the Oxidative Status of
   Neonates with Intrauterine Growth Restriction in a Pig Model
SO NEONATOLOGY
LA English
DT Article
DE Intrauterine growth restriction; Postnatal nutrition restriction;
   Oxidative stress
ID CATCH-UP GROWTH; METABOLIC SYNDROME; FREE-RADICALS; GLUCOSE-INTOLERANCE;
   CALORIE RESTRICTION; DEFENSE CAPACITY; STRESS MARKERS; HIGH-FAT;
   OBESITY; RATS
AB Objective: In offspring with intrauterine growth restriction (IUGR), where oxidative stress may play an important role in inducing metabolic syndrome, nutrition restriction has been shown to improve oxidative status. In this study, we aimed to investigate the effect of postnatal nutrition restriction on the oxidative status of IUGR neonates. Methods: A total of twelve pairs of piglets, of normal birth-weight (NBW) and with IUGR (7 days old), respectively, were randomly allocated to have adequate nutritional intake (ANI) and restricted nutritional intake (RNI) for a period of 21 days, respectively. This design produced 4 experimental groups: NBW-ANI, IUGR-ANI, NBW-RNI and IUGR-RNI (n = 6 per group). Serum, ileum and liver samples were analyzed for antioxidant parameters and the mRNA expression of genes with regard to oxidative status. The data were subjected to general linear model analysis and Duncan's test with a 5% significance level. Results: Irrespective of nutritional intake, the IUGR pigs had markedly lower activity of glutathione peroxidase (GP(x)), gene expressions of liver mitochondrial manganese superoxide dismutase (Mn-SOD) and ileum cytoplasmic copper/zinc (CuZn)-SOD and, accordingly, there was a markedly higher malondialdehyde concentration in the liver of these pigs compared to in the NBW pigs. Irrespective of body weight, pigs receiving ANI treatment had significantly lower activities of antioxidant enzymes in the serum (total antioxidative capability, CuZn-SOD and GP(x)) and liver (total SOD and glutathione reductase) and decreased gene expression of liver CuZn-SOD and Mn-SOD compared to the pig's receiving RNI. In addition, the IUGR pigs had a markedly lower concentration of liver reduced glutathione (GSH), ratio of GSH to oxidized glutathione, gene expression of ileum CuZn-SOD and extracellular SOD than the NBW pigs when receiving ANI, but not all of these differences were observed in those receiving RNI. Conclusion: IUGR neonates may have poor antioxidant defense systems, and postnatal nutrition restriction has the potential to prevent oxidative stress. (C) 2014 S. Karger AG, Basel
C1 [Che, Lianqiang; Xuan, Yue; Hu, Liang; Liu, Yan; Xu, Qin; Fang, Zhengfeng; Lin, Yan; Xu, Shengyu; Wu, De; Zhang, Keying; Chen, Daiwen] Sichuan Agr Univ, Key Lab Anim Dis Resistant Nutr, Inst Anim Nutr, Minist Educ, Chengdu 611130, Sichuan, Peoples R China.
C3 Ministry of Education - China; Sichuan Agricultural University
RP Che, LQ (corresponding author), Sichuan Agr Univ, Key Lab Anim Dis Resistant Nutr, Inst Anim Nutr, Minist Educ, 211 Huimin Rd, Chengdu 611130, Sichuan, Peoples R China.
EM clianqiang@hotmail.com
RI Xu, Shengyu/AFN-8288-2022; Zhang, Keying/AAG-5912-2020
OI Wu, De/0000-0003-1873-9914
FU National Natural Science Foundation, PR China [31101727]
FX This work was supported by the National Natural Science Foundation (No.
   31101727), PR China.
CR [Anonymous], 2012, COCHRANE DATABASE SY
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NR 33
TC 27
Z9 32
U1 1
U2 19
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1661-7800
EI 1661-7819
J9 NEONATOLOGY
JI Neonatology
PY 2015
VL 107
IS 2
BP 93
EP 99
DI 10.1159/000368179
PG 7
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA CB5IG
UT WOS:000349660100003
PM 25412706
DA 2025-06-11
ER

PT J
AU Monti, LD
   Galluccio, E
   Villa, V
   Fontana, B
   Spadoni, S
   Piatti, PM
AF Monti, Lucilla D.
   Galluccio, Elena
   Villa, Valentina
   Fontana, Barbara
   Spadoni, Serena
   Piatti, Pier Marco
TI Decreased diabetes risk over 9 year after 18-month oral L-arginine
   treatment in middle-aged subjects with impaired glucose tolerance and
   metabolic syndrome (extension evaluation of L-arginine study)
SO EUROPEAN JOURNAL OF NUTRITION
LA English
DT Article
DE L-Arginine; Endothelial function; Insulin secretion; Prevention of type
   2 diabetes; Oxidative stress
ID ENDOTHELIAL PROGENITOR CELLS; 10-YEAR FOLLOW-UP; INSULIN SENSITIVITY;
   ASYMMETRIC DIMETHYLARGININE; CARDIOVASCULAR-DISEASE; BETA-CELLS;
   SUPPLEMENTATION; DYSFUNCTION; RESISTANCE; SECRETION
AB Purpose This study aimed to determine whether L-arginine supplementation lasting for 18 months maintained longlasting effects on diabetes incidence, insulin secretion and sensitivity, oxidative stress, and endothelial function during 108 months among subjects at high risk of developing type 2 diabetes.
   Methods One hundred and forty-four middle-aged subjects with impaired glucose tolerance and metabolic syndrome were randomized in 2006 to an L-arginine supplementation (6.4 g orally/day) or placebo therapy lasting 18 months. This period was followed by a 90-month follow-up. The primary outcome was a diagnosis of diabetes during the 108 month study period. Secondary outcomes included changes in insulin secretion (proinsulin/c-peptide ratio), insulin sensitivity (IGI/HOMA-IR), oxidative stress (AOPPs), and vascular function. After the 18 month participation, subjects that were still free of diabetes and willing to continue their participation (104 subjects) were further followed until diabetes diagnosis, with a time span of about 9 years from baseline.
   Results Although results derived from the 18 month of the intervention study demonstrated no differences in the probability of becoming diabetics, at the end of the study, the cumulative incidence of diabetes was of 40.6% in the L-arginine group and of 57.4% in the placebo group. The adjusted HR for diabetes (L-arginine vs. placebo) was 0.66; 95% CI 0.48, 0.91; p < 0.02). Proinsulin/c-peptide ratio (p < 0.001), IGI/HOMA-IR (p < 0.01), and AOPP (p < 0.05) levels were ameliorated in L-arginine compared to placebo.
   Conclusions These results may suggest that the administration of L-arginine could delay the development of T2DM for a long period. This effect could be mediated, in some extent, by L-arginine-induced reduction in oxidative stress.
C1 [Monti, Lucilla D.; Galluccio, Elena; Fontana, Barbara; Spadoni, Serena] Ist Sci San Raffaele, Diabet Res Inst, Cardiodiabet & Core Lab Unit, Dept Internal Med, Via Olgettina 60, I-20132 Milan, Italy.
   [Villa, Valentina; Piatti, Pier Marco] Ist Sci San Raffaele, Diabet Res Inst, Dept Internal Med, Cardiometab & Clin Trials Unit, Milan, Italy.
C3 Vita-Salute San Raffaele University; IRCCS Ospedale San Raffaele;
   Vita-Salute San Raffaele University; IRCCS Ospedale San Raffaele
RP Monti, LD (corresponding author), Ist Sci San Raffaele, Diabet Res Inst, Cardiodiabet & Core Lab Unit, Dept Internal Med, Via Olgettina 60, I-20132 Milan, Italy.
EM monti.lucilla@hsr.it
RI Galluccio, Elena/GQQ-1903-2022; Monti, Lucilla/AAN-3716-2020; Piatti,
   Piermarco/AAN-3115-2020
FU Italian Ministry of Health [88]
FX Funding Italian Ministry of Health, Finalizzata no. 88, 2004.
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NR 50
TC 32
Z9 32
U1 0
U2 4
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1436-6207
EI 1436-6215
J9 EUR J NUTR
JI Eur. J. Nutr.
PD DEC
PY 2018
VL 57
IS 8
BP 2805
EP 2817
DI 10.1007/s00394-017-1548-2
PG 13
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA HB1ZF
UT WOS:000450829600013
PM 29052766
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Tunapong, W
   Apaijai, N
   Yasom, S
   Tanajak, P
   Wanchai, K
   Chunchai, T
   Kerdphoo, S
   Eaimworawuthikul, S
   Thiennimitr, P
   Pongchaidecha, A
   Lungkaphin, A
   Pratchayasakul, W
   Chattipakorn, SC
   Chattipakorn, N
AF Tunapong, Wannipa
   Apaijai, Nattayaporn
   Yasom, Sakawdaurn
   Tanajak, Pongpan
   Wanchai, Keerati
   Chunchai, Titikorn
   Kerdphoo, Sasiwan
   Eaimworawuthikul, Sathima
   Thiennimitr, Parameth
   Pongchaidecha, Anchalee
   Lungkaphin, Anusorn
   Pratchayasakul, Wasana
   Chattipakorn, Siriporn C.
   Chattipakorn, Nipon
TI Chronic treatment with prebiotics, probiotics and synbiotics attenuated
   cardiac dysfunction by improving cardiac mitochondrial dysfunction in
   male obese insulin-resistant rats
SO EUROPEAN JOURNAL OF NUTRITION
LA English
DT Article
DE Prebiotics; Probiotics; Synbiotics; Obese insulin resistance; Cardiac
   mitochondria; Systemic inflammation
ID HEART-RATE-VARIABILITY; DIET-INDUCED OBESITY; DIPEPTIDYL PEPTIDASE-4
   INHIBITOR; GUT MICROBIOTA; OXIDATIVE STRESS; GLUCOSE-INTOLERANCE;
   METABOLIC SYNDROME; BLOOD-GLUCOSE; OLIGOFRUCTOSE; INFLAMMATION
AB Purpose In metabolic syndrome, the composition of gut microbiota has been disrupted, and is associated with left ventricular (LV) dysfunction. Several types of prebiotics, probiotics, and synbiotics have been shown to exert cardio-protection by restoring gut microbiota from dysbiosis and reducing systemic inflammation. However, the effects of prebiotics such as xylooligosaccharides (XOS); probiotics such as Lactobacillus paracasei STII01 HP4, and synbiotics on metabolic and LV function in obese insulin-resistant rats have not been investigated. In this study, we hypothesized that prebiotics and probiotics improve metabolic parameters, heart rate variability (HRV), blood pressure (BP), and LV function by attenuating cardiac mitochondrial dysfunction, systemic inflammation, and oxidative stress, and that synbiotics provide greater efficacy than a single regimen in obese insulin resistance.
   Methods Rats were fed with either normal diet or high-fat diet (HFD) for 12 weeks and then rats in each dietary group were randomly subdivided into four subgroups to receive either a vehicle, prebiotics, probiotics, or synbiotics for another 12 weeks. Metabolic parameters, BP, HRV, LV function, cardiac mitochondrial function, systemic inflammation, and oxidative stress were determined.
   Results HFD-fed rats had obese insulin resistance with markedly increased systemic inflammatory marker [Serum LPS; ND; 0.6 +/- 0.1 EU/ml vs. HFD; 5.7 +/- 1.2 EU/ml (p < 0.05)], depressed HRV, and increased BP and LV dysfunction [%ejection fraction; ND; 93 +/- 2% vs. HFD; 83 +/- 2% (p < 0.05)]. Prebiotics, probiotics, and synbiotics attenuated insulin resistance by improving insulin sensitivity and lipid profiles. All interventions also improved HRV, BP, LV function [%ejection fraction; HFV; 81 +/- 2% vs. HFPE; 93 +/- 3%, HFPO; 92 +/- 1%, HFC; 92 +/- 2% (p < 0.05)] by attenuating mitochondrial dysfunction, oxidative stress, and systemic inflammation in obese insulin-resistant rats.
   Conclusion Prebiotics, probiotics, and synbiotics shared similar efficacy in reducing insulin resistance and LV dysfunction in obese insulin-resistant rats.
C1 [Tunapong, Wannipa; Apaijai, Nattayaporn; Yasom, Sakawdaurn; Tanajak, Pongpan; Wanchai, Keerati; Chunchai, Titikorn; Kerdphoo, Sasiwan; Eaimworawuthikul, Sathima; Thiennimitr, Parameth; Pongchaidecha, Anchalee; Lungkaphin, Anusorn; Pratchayasakul, Wasana; Chattipakorn, Siriporn C.; Chattipakorn, Nipon] Chiang Mai Univ, Cardiac Electrophysiol Res & Training Ctr, Fac Med, Chiang Mai 50200, Thailand.
   [Tunapong, Wannipa; Apaijai, Nattayaporn; Tanajak, Pongpan; Wanchai, Keerati; Chunchai, Titikorn; Kerdphoo, Sasiwan; Eaimworawuthikul, Sathima; Pongchaidecha, Anchalee; Lungkaphin, Anusorn; Pratchayasakul, Wasana; Chattipakorn, Siriporn C.; Chattipakorn, Nipon] Chiang Mai Univ, Ctr Excellence Cardiac Electrophysiol Res, Chiang Mai 50200, Thailand.
   [Tunapong, Wannipa; Tanajak, Pongpan; Wanchai, Keerati; Chunchai, Titikorn; Pongchaidecha, Anchalee; Lungkaphin, Anusorn; Pratchayasakul, Wasana; Chattipakorn, Nipon] Chiang Mai Univ, Dept Physiol, Cardiac Electrophysiol Unit, Fac Med, Chiang Mai 50200, Thailand.
   [Yasom, Sakawdaurn; Thiennimitr, Parameth] Chiang Mai Univ, Dept Microbiol, Fac Med, Chiang Mai 50200, Thailand.
   [Chattipakorn, Siriporn C.] Chiang Mai Univ, Dept Oral Biol & Diagnost Sci, Fac Dent, Chiang Mai 50200, Thailand.
C3 Chiang Mai University; Chiang Mai University; Chiang Mai University;
   Chiang Mai University; Chiang Mai University
RP Chattipakorn, N (corresponding author), Chiang Mai Univ, Cardiac Electrophysiol Res & Training Ctr, Fac Med, Chiang Mai 50200, Thailand.; Chattipakorn, N (corresponding author), Chiang Mai Univ, Ctr Excellence Cardiac Electrophysiol Res, Chiang Mai 50200, Thailand.; Chattipakorn, N (corresponding author), Chiang Mai Univ, Dept Physiol, Cardiac Electrophysiol Unit, Fac Med, Chiang Mai 50200, Thailand.
EM nchattip@gmail.com
RI Tanajak, Pongpan/ABB-2347-2020; Chattipakorn, Nipon/AAJ-4049-2021;
   Thiennimitr, Parameth/AAH-1761-2019
OI Chattipakorn, Nipon/0000-0003-3026-718X; Chattipakorn,
   Siriporn/0000-0003-1677-7052; YASOM, SAKAWDAURN/0000-0002-6145-938X;
   pratchayasakul, wasana/0000-0003-3970-4323; Wanchai,
   Keerati/0000-0003-2282-7909; Chunchai, Titikorn/0000-0003-4405-1208;
   Thiennimitr, Parameth/0000-0002-6339-8744
FU Thailand Research Fund Grants RTA [TRG6080005, RSA5780029]; NSTDA
   Research Chair Grant from the National Science and Technology
   Development Agency Thailand; Chiang Mai University Center of Excellence
   Award
FX This work was supported by Thailand Research Fund Grants RTA (SCC),
   TRG6080005 (NA), RSA5780029 (AL); a NSTDA Research Chair Grant from the
   National Science and Technology Development Agency Thailand (NC), and
   Chiang Mai University Center of Excellence Award (NC). The authors would
   also like to thank Ms. Gabrielle Metzler for her editorial assistance.
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NR 56
TC 70
Z9 73
U1 4
U2 29
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1436-6207
EI 1436-6215
J9 EUR J NUTR
JI Eur. J. Nutr.
PD SEP
PY 2018
VL 57
IS 6
BP 2091
EP 2104
DI 10.1007/s00394-017-1482-3
PG 14
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA GQ7KL
UT WOS:000441919500006
PM 28608320
DA 2025-06-11
ER

PT J
AU Qin, FZ
   Siwik, DA
   Luptak, I
   Hou, XY
   Wang, L
   Higuchi, A
   Weisbrod, RM
   Ouchi, N
   Tu, VH
   Calamaras, TD
   Miller, EJ
   Verbeuren, TJ
   Walsh, K
   Cohen, RA
   Colucci, WS
AF Qin, Fuzhong
   Siwik, Deborah A.
   Luptak, Ivan
   Hou, Xiuyun
   Wang, Lei
   Higuchi, Akiko
   Weisbrod, Robert M.
   Ouchi, Noriyuki
   Tu, Vivian H.
   Calamaras, Timothy D.
   Miller, Edward J.
   Verbeuren, Tony J.
   Walsh, Kenneth
   Cohen, Richard A.
   Colucci, Wilson S.
TI The Polyphenols Resveratrol and S17834 Prevent the Structural and
   Functional Sequelae of Diet-Induced Metabolic Heart Disease in Mice
SO CIRCULATION
LA English
DT Article
DE diastolic dysfunction; left ventricular hypertrophy; metabolic syndrome;
   4-OH-2-nonenol; oxidative stress
ID ACTIVATED PROTEIN-KINASE; VENTRICULAR DIASTOLIC FUNCTION;
   MYOCARDIAL-INFARCTION; OXIDATIVE STRESS; DIABETIC CARDIOMYOPATHY;
   SCIENTIFIC STATEMENT; CARDIAC-HYPERTROPHY; A/J MICE; DYSFUNCTION;
   IMPROVES
AB Background-Diet-induced obesity is associated with metabolic heart disease characterized by left ventricular hypertrophy and diastolic dysfunction. Polyphenols such as resveratrol and the synthetic flavonoid derivative S17834 exert beneficial systemic and cardiovascular effects in a variety of settings including diabetes mellitus and chronic hemodynamic overload.
   Methods and Results-We characterized the structural and functional features of a mouse model of diet-induced metabolic syndrome and used the model to test the hypothesis that the polyphenols prevent myocardial hypertrophy and diastolic dysfunction. Male C57BL/6J mice were fed a normal diet or a diet high in fat and sugar (HFHS) with or without concomitant treatment with S17834 or resveratrol for up to 8 months. HFHS diet-fed mice developed progressive left ventricular hypertrophy and diastolic dysfunction with preservation of systolic function in association with myocyte hypertrophy and interstitial fibrosis. In HFHS diet-fed mice, there was increased myocardial oxidative stress with evidence of oxidant-mediated protein modification via tyrosine nitration and 4-OH-2-nonenol adduction. HFHS diet-fed mice also exhibited increases in plasma fasting glucose, insulin, and homeostasis model assessment of insulin resistance indicative of insulin resistance. Treatment with S17834 or resveratrol prevented left ventricular hypertrophy and diastolic dysfunction. For S17834, these beneficial effects were associated with decreases in oxidant-mediated protein modifications and hyperinsulinemia and increased plasma adiponectin.
   Conclusions-Resveratrol and S17834 administered concurrently with a HFHS diet prevent the development of left ventricular hypertrophy, interstitial fibrosis, and diastolic dysfunction. Multiple mechanisms may contribute to the beneficial effects of the polyphenols, including a reduction in myocardial oxidative stress and related protein modifications, amelioration of insulin resistance, and increased plasma adiponectin. The polyphenols resveratrol and S17834 may be of value in the prevention of diet-induced metabolic heart disease. (Circulation. 2012;125:1757-1764.)
C1 [Colucci, Wilson S.] Boston Univ, Med Ctr, Cardiovasc Med Sect, Dept Med, Boston, MA 02118 USA.
   Boston Univ, Med Ctr, Myocardial Unit, Boston, MA 02118 USA.
   Boston Univ, Med Ctr, Vasc Biol Unit, Boston, MA 02118 USA.
C3 Boston University; Boston University; Boston University
RP Colucci, WS (corresponding author), Boston Univ, Med Ctr, Cardiovasc Med Sect, Dept Med, 88 E Newton St, Boston, MA 02118 USA.
EM wilson.colucci@bmc.org
RI OUCHI, Noriyuki/I-7306-2014; zhou, zhou/HPE-9525-2023
OI Qin, Fuzhong/0000-0002-9534-3617; Luptak, Ivan/0000-0001-7498-7694;
   Colucci, Wilson/0000-0002-0576-9420; /0000-0002-1070-6408; Miller,
   Edward/0000-0002-2156-5962; /0000-0002-7166-327X
FU National Institutes of Health [HL-061639, HL-064750, HL031607, PO1 HL
   068758]; National Heart, Lung, and Blood Institute [N01-HV-28178];
   Strategic Alliance between Servier and the Vascular Biology Section,
   Boston University Medical Center
FX This study was supported by National Institutes of Health grants
   HL-061639 (Dr Colucci), HL-064750 (Dr Colucci), HL031607 (Dr Cohen), and
   PO1 HL 068758 (Drs Cohen and Walsh), the National Heart, Lung, and Blood
   Institute-sponsored Boston University Cardiovascular Proteomics Center
   (contract N01-HV-28178; Drs Cohen and Colucci), and a Strategic Alliance
   between Servier and the Vascular Biology Section, Boston University
   Medical Center (Dr Cohen).
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NR 40
TC 98
Z9 113
U1 1
U2 18
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0009-7322
J9 CIRCULATION
JI Circulation
PD APR 10
PY 2012
VL 125
IS 14
BP 1757
EP U127
DI 10.1161/CIRCULATIONAHA.111.067801
PG 14
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 925WR
UT WOS:000302793300017
PM 22388319
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Mizuno, K
   Watanabe, K
   Yamano, E
   Ebisu, K
   Tajima, K
   Nojima, J
   Ohsaki, Y
   Kabayama, S
   Watanabe, Y
AF Mizuno, Kei
   Watanabe, Kyosuke
   Yamano, Emi
   Ebisu, Kyoko
   Tajima, Kanako
   Nojima, Junzo
   Ohsaki, Yusuke
   Kabayama, Shigeru
   Watanabe, Yasuyoshi
TI Antioxidant effects of continuous intake of electrolyzed hydrogen water
   in healthy adults
SO HELIYON
LA English
DT Article
DE Electrolyzed hydrogen water; Antioxidant oxidative stress; In
   flammation; LDL cholesterol; Renal function
ID SUBCUTANEOUS ADIPOSE-TISSUE; OXIDATIVE STRESS; METABOLIC SYNDROME;
   REDUCED WATER; ASSOCIATION; FATIGUE; MARKER
AB Chronic oxidative stress induces deterioration of health and a risk for the onset of various diseases. Previous clinical studies revealed that electrolyzed hydrogen water (EHW) is effective to reduce oxidative stress during hemodialysis in patients with chronic dialysis. In the present observational study, we investigated the antioxidant effects of a daily continuous intake of EHW in healthy adults. The concentrations of serum reactive oxygen metabolites-derived compounds (d-ROMs) and blood urea nitrogen in healthy volunteers (n = 64) who had a habit of intake over 500 mL/day of EHW at least 5 days a week for longer than 6 months were lower than those of age-and sex-matched controls (n = 470) without the habit of EHW intake. Oxidation stress index which the ratio between concentrations in d-ROMs and biological antioxidant potential was correlated with the serum concentration of high-sensitivity C-reactive protein or low-density lipoprotein cholesterol in the EHW group. These re-sults suggest that the continuous intake of EHW induces antioxidant effects and may contribute to alleviate the risk of various oxidative stress-related dysfunctions and diseases in healthy adults.
C1 [Mizuno, Kei; Watanabe, Kyosuke; Yamano, Emi; Ebisu, Kyoko; Tajima, Kanako; Watanabe, Yasuyoshi] RIKEN Ctr Biosyst Dynam Res, Lab Pathophysiol & Hlth Sci, Chuo Ku, 6-7-3 Minatojima Minamimachi, Kobe, Hyogo 6500047, Japan.
   [Mizuno, Kei; Watanabe, Kyosuke; Yamano, Emi; Ebisu, Kyoko; Tajima, Kanako; Watanabe, Yasuyoshi] RIKEN Compass Healthy Life Res Complex Program, Chuo Ku, 6-7-1 Minatojima Minamimachi, Kobe, Hyogo 6500047, Japan.
   [Mizuno, Kei; Watanabe, Kyosuke; Yamano, Emi; Watanabe, Yasuyoshi] Osaka City Univ, Kita Ku, Ctr Hlth Sci Innovat, 3-1 Ofuka Cho, Osaka, Osaka 5300011, Japan.
   [Nojima, Junzo] Yamaguchi Univ, Dept Lab Sci, Fac Hlth Sci, Grad Sch Med, I-1-1 Minami Kogushi, Ube, Yamaguchi 7558505, Japan.
   [Ohsaki, Yusuke] Tohoku Univ, Grad Sch Agr Sci, Lab Nutr, Aoba Ku, 468-1 Aramaki Aza Aoba, Sendai, Miyagi 9808572, Japan.
   [Kabayama, Shigeru] Trim Med Inst Co Ltd, 22F HERBIS ENT Off Tower 2-2-22 Umeda,City, Osaka, Osaka 5300001, Japan.
C3 RIKEN; Osaka Metropolitan University; Yamaguchi University; Tohoku
   University
RP Watanabe, Y (corresponding author), RIKEN Ctr Biosyst Dynam Res, Lab Pathophysiol & Hlth Sci, Chuo Ku, 6-7-3 Minatojima Minamimachi, Kobe, Hyogo 6500047, Japan.; Watanabe, Y (corresponding author), RIKEN Compass Healthy Life Res Complex Program, Chuo Ku, 6-7-1 Minatojima Minamimachi, Kobe, Hyogo 6500047, Japan.; Watanabe, Y (corresponding author), Osaka City Univ, Kita Ku, Ctr Hlth Sci Innovat, 3-1 Ofuka Cho, Osaka, Osaka 5300011, Japan.
EM yywata@riken.jp
RI Yamano, Emi/AAL-6201-2020; kabayama, shigeru/MFH-2923-2025
OI Watanabe, Yasuyoshi/0000-0003-2623-5599; Watanabe,
   Kyosuke/0000-0001-6261-5690
FU Nihon Trim Co., Ltd [2022-0250]; Japan Science and Technology Agency
   (JST) [RC-01]; Grants-in-Aid for Scientific Research [20K05918] Funding
   Source: KAKEN
FX This work was supported by Nihon Trim Co., Ltd (2022-0250) and RIKEN
   Compass to Healthy Life Research Complex Program (RC-01) of the Japan
   Science and Technology Agency (JST).
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NR 22
TC 2
Z9 2
U1 2
U2 9
PU CELL PRESS
PI CAMBRIDGE
PA 50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA
EI 2405-8440
J9 HELIYON
JI Heliyon
PD NOV
PY 2022
VL 8
IS 11
AR e11853
DI 10.1016/j.heliyon.2022.e11853
EA NOV 2022
PG 4
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 8L1EK
UT WOS:000923531700013
PM 36468139
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Adams, SW
   Allwood, MA
AF Adams, Shane W.
   Allwood, Maureen A.
TI Parallel Processes of Posttraumatic Stress and Cardiometabolic
   Dysfunction: A Systemic Illness of Traumatic Stress
SO HEALTH PSYCHOLOGY
LA English
DT Article
DE posttraumatic stress disorder; traumatic stress; physical health;
   cardiometabolic; systemic illness
ID WORLD-TRADE-CENTER; METABOLIC SYNDROME; HEART-DISEASE; SEPTEMBER 11;
   DISORDER; VALIDITY; RISK; CONSEQUENCES; LONELINESS; PREVALENCE
AB Objective: To determine if and how cardiometabolic conditions (MetC) may be associated with posttraumatic stress disorder (PTSD) symptoms over time when controlling for the influence of potentially confounding variables. Method: Parallel process latent growth modeling was applied to self-reported longitudinal data collected from 35,788 World Trade Center 9/11 survivors to determine how the development and course of PTSD symptoms and MetC influence each other when controlling for age, sex, race/ethnicity, preexisting traumas, physical health problems, general psychological distress, smoking, and alcohol use. Results: A unidirectional relationship was found in which the intercept of PTSD symptoms predicted the slope of MetC. Hyperarousal (beta = .172) and emotional numbing (beta = .171) PTSD symptoms demonstrated the strongest association with MetC changes over and above the effects of control variables and potential confounders. Post hoc analyses indicated that utilization of PTSD-related psychotherapy was associated with decreased early presentations of MetC following trauma, which may have vital implications for the integrated treatment of trauma-exposed individuals. Conclusions: Findings have strong theoretical and clinical implications for conceptualizing traumatic stress reactions as systemic processes and utilizing integrated treatment practices following psychological trauma.
C1 [Adams, Shane W.; Allwood, Maureen A.] CUNY, John Jay Coll Criminal Justice, Dept Psychol, New York, NY USA.
   [Adams, Shane W.; Allwood, Maureen A.] CUNY, Grad Ctr, Dept Psychol, New York, NY USA.
   [Adams, Shane W.] VA Palo Alto Hlth Care Syst, 3801 Miranda Ave, Palo Alto, CA 94304 USA.
C3 City University of New York (CUNY) System; City University of New York
   (CUNY) System; US Department of Veterans Affairs; Veterans Health
   Administration (VHA); VA Palo Alto Health Care System
RP Adams, SW (corresponding author), VA Palo Alto Hlth Care Syst, 3801 Miranda Ave, Palo Alto, CA 94304 USA.
EM swadams2@gmail.com
RI Adams, Shane/V-1657-2019
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NR 51
TC 4
Z9 4
U1 0
U2 7
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 0278-6133
EI 1930-7810
J9 HEALTH PSYCHOL
JI Health Psychol.
PD MAY
PY 2024
VL 43
IS 5
BP 365
EP 375
DI 10.1037/hea0001347
EA DEC 2023
PG 11
WC Psychology, Clinical; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology
GA I1J5K
UT WOS:001128695500001
PM 38127510
DA 2025-06-11
ER

PT J
AU Musazadeh, V
   Mahmoudinezhad, M
   Hamidi, N
   Falahatzadeh, M
   Shidfar, F
AF Musazadeh, Vali
   Mahmoudinezhad, Mahsa
   Hamidi, Niloofar
   Falahatzadeh, Maryam
   Shidfar, Farzad
TI Effects of walnut consumption on biomarkers of oxidative stress: A
   systematic review and meta-analysis of randomized controlled trials
SO PROSTAGLANDINS & OTHER LIPID MEDIATORS
LA English
DT Review
DE Biomarker; Meta-analysis; Metabolic syndrome; Stress oxidative; Walnut
ID ANTIOXIDANT STATUS; CAPACITY; POLYPHENOLS; DERIVATIVES; PLASMA; PHASE;
   ASSAY; ACID; MEAT
AB Oxidative stress is caused by an imbalance between accumulation and production of oxygen reactive species (ROS) in tissues and cells and play a key role in many diseases. This systematic review and meta-analysis of randomized controlled trials (RCTs) was performed to analyze the effects of walnut consumption on biomarkers of oxidative stress. Databases including PubMed, Scopus, Embase and Web of science were searched until November 30th, 2024. Data were subjected to meta-analysis using a random effects model to examine the effect sizes of the pooled results. Four studies were identified eligible to be included in current meta-analysis. Walnut consumption resulted in a significant increase in catalase activity (CAT) (WMD: 42.20; 95 % CI: 34.28, 50.11). Walnut consumption did not affect other biomarkers of oxidative stress such as lipid peroxidation (LPO), reduced glutathione (GSH), oxidized glutathione (GSSG) and oxygen radical absorbance capacity (ORAC). Overall, this meta-analysis demonstrated walnut consumption increase CAT, but did not affect other biomarkers of oxidative stress. This suggests that walnut may have played an indirect and mild role in health. However, due to the limited number of studies, further investigations is suggested in this regard.
C1 [Musazadeh, Vali; Hamidi, Niloofar] Iran Univ Med Sci, Student Res Comm, Sch Publ Hlth, Tehran, Iran.
   [Musazadeh, Vali; Shidfar, Farzad] Iran Univ Med Sci, Sch Publ Hlth, Dept Nutr, Tehran, Iran.
   [Mahmoudinezhad, Mahsa] Urmia Univ Med Sci, Student Res Comm, Orumiyeh, Iran.
   [Mahmoudinezhad, Mahsa] Urmia Univ Med Sci, Food & Beverages Safety Res Ctr, Orumiyeh, Iran.
   [Falahatzadeh, Maryam] Shiraz Univ Med Sci, Dept Pharm, Shiraz, Iran.
C3 Iran University of Medical Sciences; Iran University of Medical
   Sciences; Urmia University of Medical Sciences; Urmia University of
   Medical Sciences; Shiraz University of Medical Science
RP Shidfar, F (corresponding author), Iran Univ Med Sci, Sch Publ Hlth, Dept Nutr, Tehran, Iran.
EM Mosazadeh.vali05@gmail.com; farzadshidfar@yahoo.com
RI Shidfar, Farzad/H-6651-2018
FU Student Research Committee, School of Public Health, Iran University of
   Medical Sciences, Tehran, Iran Tehran, Iran [33392]
FX This study was financially supported by a grant from the Student
   Research Committee, School of Public Health, Iran University of Medical
   Sciences, Tehran, Iran Tehran, Iran (Registration code: 33392) .
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NR 35
TC 0
Z9 0
U1 1
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1098-8823
EI 2212-196X
J9 PROSTAG OTH LIPID M
JI Prostaglandins Other Lipid Mediat.
PD JUN
PY 2025
VL 178
AR 106986
DI 10.1016/j.prostaglandins.2025.106986
PG 6
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA 1FU9M
UT WOS:001464009400001
PM 40187548
DA 2025-06-11
ER

PT J
AU Lotti, F
   Maggi, M
AF Lotti, Francesco
   Maggi, Mario
TI Sexual dysfunction and male infertility
SO NATURE REVIEWS UROLOGY
LA English
DT Review
ID PREMATURE EJACULATION SYNDROMES; 4TH INTERNATIONAL CONSULTATION; SEMEN
   QUALITY IMPAIRMENT; HELP-SEEKING BEHAVIOR; ERECTILE DYSFUNCTION;
   CLOMIPHENE CITRATE; HEALTH-STATUS; DOUBLE-BLIND; TESTOSTERONE LEVELS;
   METABOLIC SYNDROME
AB Infertility affects up to 12% of all men, and sexual dysfunction occurs frequently in men of reproductive age, causing infertility in some instances. In infertile men, hypoactive sexual desire and lack of sexual satisfaction are the most prevalent types of sexual dysfunction, ranging from 8.9% to 68.7%. Erectile dysfunction and/or premature ejaculation, evaluated with validated tools, have a prevalence of one in six infertile men, and orgasmic dysfunction has a prevalence of one in ten infertile men. In addition, infertile men can experience a heavy psychological burden. Infertility and its associated psychological concerns can underlie sexual dysfunction. Furthermore, general health perturbations can lead to male infertility and/or sexual dysfunction. Erectile dysfunction and male infertility are considered proxies for general health, the former underlying cardiovascular disorders and the latter cancerous and noncancerous conditions. The concept that erectile dysfunction in infertile men might be an early marker of poor general health is emerging. Finally, medications used for general health problems can cause sperm abnormalities and sexual dysfunction. The treatment of some causes of male infertility might improve semen quality and reverse infertility-related sexual dysfunction. In infertile men, an investigation of sexual, general, and psychological health status is advisable to improve reproductive problems and general health.
C1 [Lotti, Francesco; Maggi, Mario] Univ Florence, Dept Expt & Clin Biomed Sci, Sexual Med & Androl Unit, Florence, Italy.
C3 University of Florence
RP Maggi, M (corresponding author), Univ Florence, Dept Expt & Clin Biomed Sci, Sexual Med & Androl Unit, Florence, Italy.
EM m.maggi@dfc.unifi.it
RI Maggi, Mario/AAB-8284-2019; Lotti, Francesco/AAC-3186-2019; LOTTI,
   Francesco/K-1801-2018
OI MAGGI, Mario/0000-0003-3267-4221; LOTTI, Francesco/0000-0001-8343-1807
FU Ministry of University and Scientific Research (SIR project)
   [RBSI14LFMQ]
FX This work is funded by the Ministry of University and Scientific
   Research (SIR project to F.L. protocol number: RBSI14LFMQ).
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NR 252
TC 218
Z9 232
U1 3
U2 45
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 1759-4812
EI 1759-4820
J9 NAT REV UROL
JI Nat. Rev. Urol.
PD MAY
PY 2018
VL 15
IS 5
BP 287
EP 307
DI 10.1038/nrurol.2018.20
PG 21
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Urology & Nephrology
GA GE4OA
UT WOS:000431194200009
PM 29532805
DA 2025-06-11
ER

PT J
AU Caron, JP
   Ernyey, H
   Rosenthal, MD
AF Caron, Jesse Pittard
   Ernyey, Helen
   Rosenthal, Martin D.
TI Can caloric restriction improve outcomes of elective surgeries?
SO JOURNAL OF PARENTERAL AND ENTERAL NUTRITION
LA English
DT Review
DE bariatric surgery; critical care; metabolic diseases; metabolic
   syndrome; nutrition; research and diseases; surgery; weight loss
ID DISEASE RISK MARKERS; BODY-MASS INDEX; WEIGHT-LOSS; INSULIN-RESISTANCE;
   BARIATRIC SURGERY; ENERGY RESTRICTION; INTERMITTENT ENERGY; COLORECTAL
   SURGERY; ENHANCED-RECOVERY; OVERWEIGHT
AB Energy restriction (ER) is a nutrition method to reduce the amount of energy intake while maintaining adequate nutrition. In clinical medicine, applications of ER have been implicated in longevity, mortality, metabolic, immune, and psychological health. However, there are limited studies showing the clinical benefit of ER within the immediate surgical setting. A specific, clinically oriented summary of the potential applications of ER is needed to optimize surgery outcomes for patients. The purpose of this article is to examine how ER can be used for perioperative optimization to improve outcomes for the patient and surgeon. It will also explore how these outcomes can feasibly fit in with enhanced recovery after surgery protocols and can be used as a method for nutrition optimization in surgery. Despite evidence of caloric restriction improving outcomes in critically ill surgical patients, there is not enough evidence to conclude that ER, perioperatively across noncritically ill cohorts, improves postoperative morbidity and mortality in elective surgeries. Nevertheless, a contemporary account of how ER techniques may have a significant role in reducing risk factors of adverse surgical outcomes in this cohort, for example, by encouraging preoperative weight loss contributing to decreased operating times, is reviewed.
C1 [Caron, Jesse Pittard] Advent Hlth Orlando, Dept Gen Surg, Orlando, FL 32803 USA.
   [Ernyey, Helen; Rosenthal, Martin D.] Univ Florida, Dept Surg, Gainesville, FL USA.
C3 Adventist Health Services; AdventHealth; State University System of
   Florida; University of Florida
RP Caron, JP (corresponding author), Advent Hlth Orlando, Dept Gen Surg, Orlando, FL 32803 USA.
EM Jesse.p.caron.md@adventhealth.com
OI Rosenthal, Martin/0000-0002-5682-0994
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NR 92
TC 0
Z9 0
U1 0
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0148-6071
EI 1941-2444
J9 JPEN-PARENTER ENTER
JI J. Parenter. Enter. Nutr.
PD AUG
PY 2024
VL 48
IS 6
BP 646
EP 657
DI 10.1002/jpen.2642
EA MAY 2024
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA A5S8P
UT WOS:001231867800001
PM 38802250
DA 2025-06-11
ER

PT J
AU Sproesser, G
   Klusmann, V
   Ruby, MB
   Arbit, N
   Rozin, P
   Schupp, HT
   Renner, B
AF Sproesser, Gudrun
   Klusmann, Verena
   Ruby, Matthew B.
   Arbit, Naomi
   Rozin, Paul
   Schupp, Harald T.
   Renner, Britta
TI The positive eating scale: relationship with objective health parameters
   and validity in Germany, the USA and India
SO PSYCHOLOGY & HEALTH
LA English
DT Article
DE assessment; cross-country validity; normal eating; objective health
   parameters; positive relationship with eating
ID QUALITY-OF-LIFE; METABOLIC SYNDROME; FOOD; VALIDATION; COMPETENCE;
   QUESTIONNAIRE; SATISFACTION; WEIGHT; NUMBER; ASSOCIATIONS
AB Objective: The prevailing focus regarding eating behaviour is on restriction, concern, worry and pathology. In contrast, the purpose of the present studies was to focus on a positive relationship with eating in non-clinical samples from Germany, the USA and India.Design: In Study 1, the Positive Eating Scale (PES) was tested and validated in a large longitudinal sample (T1: N=772; T2: N=510). In Study 2, the PES was tested in online samples from the USA, India and Germany (total N=749).Main Outcome Measures: Health risk status was measured in Study 1 with objective health parameters (fasting serum glucose, triglycerides, high-density lipoprotein cholesterol, blood pressure, waist circumference, BMI).Results: Study 1 revealed acceptable psychometric properties of the PES, internal consistency (=.87), as well as test-retest reliability after six months (r=.67). Importantly, a positive relationship with eating was associated with decreased health risk factors six months later. In Study 2, the structure of the PES was confirmed for German, Indian and US-American adults, suggesting validity across remarkably different eating environments.Conclusion: A positive relationship with eating might be a fruitful starting point for prevention and intervention programmes promoting physical and psychological health.
C1 [Sproesser, Gudrun; Klusmann, Verena; Renner, Britta] Univ Konstanz, Psychol Assessment & Hlth Psychol, Constance, Germany.
   [Ruby, Matthew B.; Rozin, Paul] Univ Penn, Dept Psychol, 3815 Walnut St, Philadelphia, PA 19104 USA.
   [Arbit, Naomi] Columbia Univ, Dept Nutr, New York, NY USA.
   [Schupp, Harald T.] Univ Konstanz, Gen Psychol, Constance, Germany.
   [Ruby, Matthew B.] La Trobe Univ, Bundoora, Vic, Australia.
C3 University of Konstanz; University of Pennsylvania; Columbia University;
   University of Konstanz; La Trobe University
RP Sproesser, G (corresponding author), Univ Konstanz, Psychol Assessment & Hlth Psychol, Constance, Germany.
EM gudrun.sproesser@uni-konstanz.de
RI Klusmann, Verena/AAO-2452-2020; Ruby, Matthew/AHD-4281-2022; Renner,
   Britta/AAW-1895-2020
OI Sproesser, Gudrun/0000-0002-4223-2614; Ruby,
   Matthew/0000-0002-9562-6510; Schupp, Harald/0000-0002-1725-9129;
   Klusmann, Verena/0000-0001-7928-7793; Renner, Britta/0000-0001-8385-2839
FU Federal Ministry of Education and Research [01EA1326, 01EL1420A];
   Zukunftskolleg of the University of Konstanz within the Excellence
   Initiative of the German Federal Governments
FX This work was supported by the Federal Ministry of Education and
   Research within the projects EATMOTIVE [grant number 01EA1326], granted
   to Britta Renner & Harald Schupp and SmartAct [grant number 01EL1420A],
   granted to Britta Renner & Harald Schupp. Additional funding came from
   the Zukunftskolleg of the University of Konstanz within the second
   funding period of the Excellence Initiative of the German Federal
   Governments (granted to Gudrun Sproesser).
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NR 101
TC 19
Z9 20
U1 2
U2 19
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0887-0446
EI 1476-8321
J9 PSYCHOL HEALTH
JI Psychol. Health
PY 2018
VL 33
IS 3
BP 313
EP 339
DI 10.1080/08870446.2017.1336239
PG 27
WC Public, Environmental & Occupational Health; Psychology,
   Multidisciplinary
WE Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; Psychology
GA FX1FO
UT WOS:000425794400002
PM 28641449
DA 2025-06-11
ER

PT J
AU Keil, MF
AF Keil, Margaret F.
TI Quality of Life and Other Outcomes in Children Treated for Cushing
   Syndrome
SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Review
ID BONE-MINERAL DENSITY; TERM-FOLLOW-UP; PITUITARY-ADRENAL AXIS; LONG-TERM;
   TRANSSPHENOIDAL SURGERY; SURGICAL CURE; BILATERAL ADRENALECTOMY;
   CONSENSUS STATEMENT; CARDIOVASCULAR RISK; METABOLIC SYNDROME
AB Context: Cushing syndrome (CS) in children is associated with residual impairment in measures of health-related quality of life, even after successful resolution of hypercortisolemia, highlighting the need for early identification of morbidities and improvements in long-term management of these patients.
   Evidence Acquisition and Synthesis: A PubMed, Scopus, and Web of Science search of articles from 1900 onward identified available studies related to quality of life and complications of pediatric CS as well as important historical articles. This review summarizes studies through November 2012 and highlights recent developments.
   Conclusions: A review of the literature identifies significant morbidities associated with CS of pediatric onset, which must not be treated in isolation. CS affects children and adolescents in many ways that are different than adults. Post-treatment challenges for the child or adolescent treated for CS include: optimize growth and pubertal development, normalize body composition, and promote psychological health and cognitive maturation. All these factors impact health-related quality of life, which is an important outcome measure to assess the burden of disease as well as the effect of treatment. Future research efforts are needed to improve management of the physical, psychological, and emotional aspects of this disease in order to diminish the residual impairments experienced by the pediatric CS patient population.
C1 [Keil, Margaret F.] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Sect Endocrinol Genet, Program Dev Endocrinol Genet, NIH, Bethesda, MD 20892 USA.
C3 National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver
   National Institute of Child Health & Human Development (NICHD)
RP Keil, MF (corresponding author), NICHHD, Program Dev Endocrinol Genet, NIH, East Labs,CRC, Bldg 10,Room I-3330,10 Ctr Dr,MSC1103, Bethesda, MD 20892 USA.
EM keilm@mail.nih.gov
FU Intramural Programs of the Eunice Kennedy Shriver Intramural Project,
   National Institute of Child Health and Human Development, National
   Institutes of Health [Z01-HD-000642-04]
FX This work was supported by the Intramural Programs of the Eunice Kennedy
   Shriver Intramural Project Z01-HD-000642-04 (to C.A.S.), National
   Institute of Child Health and Human Development, National Institutes of
   Health.
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NR 120
TC 28
Z9 30
U1 0
U2 10
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0021-972X
EI 1945-7197
J9 J CLIN ENDOCR METAB
JI J. Clin. Endocrinol. Metab.
PD JUL
PY 2013
VL 98
IS 7
BP 2667
EP 2678
DI 10.1210/jc.2013-1123
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 196MV
UT WOS:000322780600026
PM 23640970
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Al Suwaidi, J
   Higano, ST
   Holmes, DR
   Lerman, A
AF Al Suwaidi, J
   Higano, ST
   Holmes, DR
   Lerman, A
TI Pathophysiology, diagnosis, and current management strategies for chest
   pains in patients with normal findings on angiography
SO MAYO CLINIC PROCEEDINGS
LA English
DT Review
ID NORMAL CORONARY-ARTERIES; TERM FOLLOW-UP; L-ARGININE SUPPLEMENTATION;
   EXERCISE-INDUCED ANGINA; ST SEGMENT DEPRESSION; CARDIAC SYNDROME-X; COLD
   PRESSOR TEST; ENDOTHELIAL DYSFUNCTION; MICROVASCULAR ANGINA; MYOCARDIAL
   PERFUSION
AB Chest pain syndromes in patients with normal angiographic findings represent a multifactorial pathophysiologic state, which may range from abnormalities in pain perception to abnormalities in endothelial- and non-endothelial-dependent coronary flow reserve associated with myocardial ischemia. Treatment begins with an accurate diagnosis by obtaining a comprehensive history and performing a physical examination, followed possibly by performing functional angiography in those who continue to have symptoms. This approach may help to determine appropriate treatment.
C1 Mayo Clin & Mayo Fdn, Div Cardiovasc Dis & Internal Med, Rochester, MN 55905 USA.
C3 Mayo Clinic
RP Mayo Clin & Mayo Fdn, Div Cardiovasc Dis, 200 1st St SW, Rochester, MN 55905 USA.
EM lerman.amir@mayo.edu
OI al suwaidi, MB, ChB, FACC, FESC, FSCAI, jassim/0000-0002-5299-9106
FU NHLBI NIH HHS [HL63911] Funding Source: Medline
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NR 102
TC 26
Z9 26
U1 0
U2 4
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0025-6196
EI 1942-5546
J9 MAYO CLIN PROC
JI Mayo Clin. Proc.
PD AUG
PY 2001
VL 76
IS 8
BP 813
EP 822
PG 10
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 460HF
UT WOS:000170301600010
PM 11499821
DA 2025-06-11
ER

PT J
AU Rupérez, AI
   Gil, A
   Aguilera, CM
AF Ruperez, Azahara I.
   Gil, Angel
   Aguilera, Concepcion M.
TI Genetics of Oxidative Stress in Obesity
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE polymorphism; oxidative stress; reactive oxygen species; antioxidant
   enzymes; obesity
ID MANGANESE SUPEROXIDE-DISMUTASE; METHIONINE SULFOXIDE REDUCTASE;
   DIET-INDUCED OBESITY; BODY-MASS INDEX; INSULIN-RESISTANCE;
   GLUTATHIONE-PEROXIDASE; METABOLIC SYNDROME; ADIPOSE-TISSUE; ANTIOXIDANT
   DEFENSE; SERUM PARAOXONASE
AB Obesity is a multifactorial disease characterized by the excessive accumulation of fat in adipose tissue and peripheral organs. Its derived metabolic complications are mediated by the associated oxidative stress, inflammation and hypoxia. Oxidative stress is due to the excessive production of reactive oxygen species or diminished antioxidant defenses. Genetic variants, such as single nucleotide polymorphisms in antioxidant defense system genes, could alter the efficacy of these enzymes and, ultimately, the risk of obesity; thus, studies investigating the role of genetic variations in genes related to oxidative stress could be useful for better understanding the etiology of obesity and its metabolic complications. The lack of existing literature reviews in this field encouraged us to gather the findings from studies focusing on the impact of single nucleotide polymorphisms in antioxidant enzymes, oxidative stress-producing systems and transcription factor genes concerning their association with obesity risk and its phenotypes. In the future, the characterization of these single nucleotide polymorphisms (SNPs) in obese patients could contribute to the development of controlled antioxidant therapies potentially beneficial for the treatment of obesity-derived metabolic complications.
C1 [Ruperez, Azahara I.; Gil, Angel; Aguilera, Concepcion M.] Univ Granada, Ctr Biomed Res, Inst Nutr & Food Technol, Dept Biochem & Mol Biol 2, Granada 18100, Spain.
C3 University of Granada
RP Aguilera, CM (corresponding author), Univ Granada, Ctr Biomed Res, Inst Nutr & Food Technol, Dept Biochem & Mol Biol 2, Granada 18100, Spain.
EM caguiler@ugr.es
RI Rupérez, Azahara/L-3771-2019; Aguilera, Concepcion/M-1663-2014; Gil,
   Angel/L-2275-2014
OI Aguilera, Concepcion/0000-0002-1451-4788; Ruperez, Azahara
   I./0000-0002-3850-8235; Gil, Angel/0000-0001-7663-0939
FU Instituto de Salud Carlos III-Fondo de Investigacion Sanitaria (FIS)
   [PI11/02042, PI05/1968]; Redes tematicas de investigacion cooperativa
   (RETIC), Research Network on Maternal and Child Health and Development
   (SAMID) [RD08/0072/0028, SAMID RD12/0026/0015]; Junta de Andalucia,
   Consejeria de Innovacion y Ciencia [P06-CTS 2203, PI-0296/2007];
   Formacion de Profesorado Universitario (FPU); Ministry of Education and
   Science of the Spanish Government [AP2009-0547]
FX The present study was funded by the Instituto de Salud Carlos III-Fondo
   de Investigacion Sanitaria (FIS) (project number: PI11/02042 and
   PI05/1968); Redes tematicas de investigacion cooperativa (RETIC),
   Research Network on Maternal and Child Health and Development (SAMID)
   RD08/0072/0028 and SAMID RD12/0026/0015; Junta de Andalucia, Consejeria
   de Innovacion y Ciencia (project number: P06-CTS 2203 and PI-0296/2007).
   Ruperez A. I was funded by a Formacion de Profesorado Universitario
   (FPU) stipend from the Ministry of Education and Science of the Spanish
   Government (AP2009-0547).
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NR 132
TC 69
Z9 76
U1 2
U2 31
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD FEB
PY 2014
VL 15
IS 2
BP 3118
EP 3144
DI 10.3390/ijms15023118
PG 27
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA AG9YP
UT WOS:000335776400086
PM 24562334
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Bijlenga, D
   van der Heijden, KB
   Breuk, M
   van Someren, EJW
   Lie, MEH
   Boonstra, AM
   Swaab, HJT
   Kooij, JJS
AF Bijlenga, Denise
   van der Heijden, Kristiaan B.
   Breuk, Minda
   van Someren, Eus J. W.
   Lie, Maria E. H.
   Boonstra, A. Marije
   Swaab, Hanna J. T.
   Kooij, J. J. Sandra
TI Associations Between Sleep Characteristics, Seasonal Depressive
   Symptoms, Lifestyle, and ADHD Symptoms in Adults
SO JOURNAL OF ATTENTION DISORDERS
LA English
DT Article
DE ADHD; sleep; circadian rhythm; seasonal depressive symptoms; sleep-onset
   latency; sleep-onset insomnia; delayed sleep phase syndrome
ID ATTENTION-DEFICIT/HYPERACTIVITY DISORDER;
   DEFICIT-HYPERACTIVITY-DISORDER; PHASE SYNDROME; BODY-MASS; LIGHT; MOOD;
   RISK; ADOLESCENTS; PREVALENCE; DURATION
AB Objective: The authors explored associations between ADHD symptoms, seasonal depressive symptoms, lifestyle, and health. Method: Adult ADHD patients (n = 202) and controls (n = 189) completed the ASESA questionnaire involving lifestyle, eating pattern, and physical and psychological health, and validated measures on ADHD and sleep. ASESA is the Dutch acronym for Inattention, Sleep, Eating pattern, Mood, and General health questionnaire. Results: Indication for delayed sleep phase syndrome (DSPS) was 26% in patients and 2% in controls (p < .001). Patients reported shorter sleep, longer sleep-onset latency, and later midsleep. Shorter (R2 = .21) and later (R2 = .27) sleep were associated with hyperactivity, male gender, younger age, and seasonal depressive symptoms. Seasonal depressive symptoms were related to hyperactivity, female gender, unemployment, and late sleep (pseudo R2 = .28). Higher body mass index (BMI) was associated with shorter sleep in patients (rho = -.16; p = .04) and controls (rho = -.17; p = .02). Longer sleep showed lower odds for indication of metabolic syndrome (OR = -0.17; p = .053). Conclusion: DSPS is more prevalent in ADHD and needs further investigation to establish treatment to prevent chronic health issues. (J. of Att. Dis. 2013; 17(3)261-275)
C1 [Bijlenga, Denise; Breuk, Minda; Boonstra, A. Marije; Kooij, J. J. Sandra] PsyQ, Expertise Ctr Adult ADHD, The Hague, Netherlands.
   [van der Heijden, Kristiaan B.; Swaab, Hanna J. T.] Leiden Univ, Ctr Study Dev Disorders, Leiden, Netherlands.
   [van Someren, Eus J. W.] Netherlands Inst Neurosci, Amsterdam, Netherlands.
   [Lie, Maria E. H.] Acad Hosp Maastricht, MedPsych Ctr, Maastricht, Netherlands.
C3 Leiden University - Excl LUMC; Leiden University; Royal Netherlands
   Academy of Arts & Sciences; Netherlands Institute for Neuroscience
   (NIN-KNAW); Maastricht University; Maastricht University Medical Centre
   (MUMC)
RP Bijlenga, D (corresponding author), PsyQ Program Adult ADHD, Carel Reinierszkade 197, NL-2593 HR The Hague, Netherlands.
EM d.bijlenga@psyq.nl
RI Swaab, Hanna/AAD-2555-2019; Van Someren, Eus/AAA-6789-2020; Kooij,
   J.J./AAK-3304-2021
OI Van Someren, Eus/0000-0002-9970-8791; Kooij, J.J.
   Sandra/0000-0002-8644-6323
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NR 66
TC 82
Z9 90
U1 1
U2 42
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1087-0547
EI 1557-1246
J9 J ATTEN DISORD
JI J. Atten. Disord.
PD APR
PY 2013
VL 17
IS 3
BP 261
EP 275
DI 10.1177/1087054711428965
PG 15
WC Psychology, Developmental; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA 112ZT
UT WOS:000316635800010
PM 22210799
DA 2025-06-11
ER

PT J
AU Azantsa, BKG
   Raissa, NF
   Mary-Ann, MA
   Amelie, M
   Alexine, K
   Cliffbrown, M
   Lauriane, CN
   Martin, F
   Ferdinand, EE
   Laure, NJ
   Oben, JE
AF Azantsa, Boris K. G.
   Raissa, Ntentie F.
   Mary-Anna, Mbong A.
   Amelie, Mafongang
   Alexine, Kamtchoum
   Cliffbrown, Momo
   Lauriane, Chimou N.
   Martin, Fonkoua
   Ferdinand, Edoun E.
   Laure, Ngondi J.
   Oben, Julius E.
TI Lipomodulatory and anti-oxidative stress effects of a polyherbal
   formulation based on garlic and avocado seed extracts on high fat high
   sucrose diet fed rats
SO METABOLISM OPEN
LA English
DT Article
DE Polyherbal formulation; Oxidative stress; Dyslipidemia; Metabolic
   syndrome; Treatment
ID INSULIN-RESISTANCE; MECHANISMS; COMPLEX; LIVER
AB Objective To determine antioxidant potentials of Allium sativum and Persea americana seeds extracts and three formulation-based extracts in vitro, and to evaluate the effects of the best formulation on oxidative stress and dyslipidemia on rats fed with high fat and high sucrose diet (HFHSD). Methods Aqueous extracts of Allium sativum, Persia. americana and three formulations were mixed at various portions (A. s/P. a; w/w): F (1:1), F (3: 1), and F(1:3). They were then tested for their antioxidant potentials in vitro using FRAP, DPPH and NO radicals to identify the best formulation. Four hundred (400) mg/kg b.w. of formulation F(1:1) were administered once daily for 21 days to rats previously fed with HFHSD for 8 weeks. Standard diet, vitamin E, and Atorvastatin were used as controls. After 21 days, body weight, blood glucose, lipid markers, activities of transaminases and markers of the antioxidant systems were assessed. Results The Formulation F(1:1) showed the best in vitro activity with IC50 values of 6.5 and 2.23 mg/mL respectively for FRAP and DPPH- radical scavenging capacity. HFHSD caused a depletion of antioxidants associated with an increase of pro-oxidants and all the lipid markers except HDL-c Treatment with F(1:1) significantly increased TAC, SOD, and catalase activities, while MDA, protein carbonyls, and NO levels decreased (p < 0.05). Formulation F(1:1) decreased triglycerides (119.88 +/- 4.25 mg/dL) and LDL-c (3.78 +/- 0.66 mg/dL) levels and significantly increased the HDL-c level: (108.07 +/- 6.29 mg/mL). Furthermore, Formulation F(1:1) significantly caused weight loss (2.31%), reduced blood glucose levels (27.38%) and ALT activity. Conclusion The formulation F(1:1) could be a good candidate for the prevention and treatment of oxidative stress, dyslipidemia and features of metabolic syndrome.
C1 [Azantsa, Boris K. G.; Raissa, Ntentie F.; Mary-Anna, Mbong A.; Amelie, Mafongang; Alexine, Kamtchoum; Cliffbrown, Momo; Lauriane, Chimou N.; Martin, Fonkoua; Ferdinand, Edoun E.; Laure, Ngondi J.; Oben, Julius E.] Univ Yaounde I, Fac Sci, Dept Biochem, Lab Nutr & Nutr Biochem, POB 812, Yaounde, Cameroon.
   [Raissa, Ntentie F.] Higher TeachersTraining Coll, Dept Life & Earth Sci, POB 55, Maroua, Cameroon.
   [Ferdinand, Edoun E.] Inst Med Res & Med Plant Studies, Ctr Food & Nutr Res, MINRESI, POB 13033, Yaounde, Cameroon.
C3 University of Yaounde I
RP Azantsa, BKG (corresponding author), Univ Yaounde I, Fac Sci, Dept Biochem, Lab Nutr & Nutr Biochem, POB 812, Yaounde, Cameroon.
EM borisazantsa@yahoo.fr
RI NTENTIE, FRANCOISE RAISSA/AGA-7101-2022
OI NTENTIE, FRANCOISE RAISSA/0000-0003-4646-8728
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NR 44
TC 3
Z9 3
U1 0
U2 1
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
EI 2589-9368
J9 METAB OPEN
JI Metab. Open
PD SEP
PY 2022
VL 15
AR 100195
DI 10.1016/j.metop.2022.100195
PG 8
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA JE8V1
UT WOS:001171588000011
PM 35757834
OA Green Published
DA 2025-06-11
ER

PT J
AU Ishizaki, M
   Morikawa, Y
   Nakagawa, H
   Honda, R
   Kawakami, N
   Haratani, T
   Kobayashi, F
   Araki, S
   Yamada, Y
AF Ishizaki, M
   Morikawa, Y
   Nakagawa, H
   Honda, R
   Kawakami, N
   Haratani, T
   Kobayashi, F
   Araki, S
   Yamada, Y
TI The influence of work characteristics on body mass index and waist to
   hip ratio in Japanese employees
SO INDUSTRIAL HEALTH
LA English
DT Article
DE waist to hip ratio; body mass index; job stress; sedentary job; shift
   work
ID CORONARY-HEART-DISEASE; INSULIN-RESISTANCE-SYNDROME; AMBULATORY
   BLOOD-PRESSURE; WHITE-COLLAR WORKERS; MIDDLE-AGED MEN; PSYCHOSOCIAL
   FACTORS; FAT DISTRIBUTION; CARDIOVASCULAR-DISEASE; SOCIOECONOMIC-STATUS;
   GLUCOSE-TOLERANCE
AB A cross-sectional study on 6,676 workers consisting of 4,243 males and 2,433 females aged 20-58 yr in a metal product factory was conducted to elucidate the relationship between work characteristics, e.g. job demand/control/support, sedentary job, overtime work and shift work, and waist to hip ratio (WHR) as well as body mass index (BMI) taking alcohol consumption, smoking, exercise and other psychosocial factors such as education and marital status into account. By a stepwise multiple regression analysis, BMI was associated with shift work, marital status and sedentary job for males, and with exercise but inversely associated with education for females. WHR was also associated with shift work, alcohol consumption, marital status and sedentary job but inversely associated with exercise for males, and with sedentary job, marital status and education but inversely associated with smoking for females. These results suggest that work characteristics such as sedentary job and shift work should also be considered when trying to prevent increases in BMI and WHR.
C1 Kanazawa Med Univ, Dept Hyg, Uchinada, Ishikawa 9200293, Japan.
   Kanazawa Med Univ, Dept Publ Hlth, Uchinada, Ishikawa 9200293, Japan.
   Okayama Univ, Grad Sch Med & Dent, Div Hyg & Prevent Med, Okayama 7008558, Japan.
   Natl Inst Ind Hlth, Tama Ku, Kawasaki, Kanagawa 2148585, Japan.
   Aichi Med Univ, Sch Med, Dept Hlth & Psychosocial Med, Nagakute, Aichi 4801195, Japan.
C3 Kanazawa Medical University; Kanazawa Medical University; Okayama
   University; Aichi Medical University
RP Ishizaki, M (corresponding author), Kanazawa Med Univ, Dept Hyg, 1-1 Daigaku, Uchinada, Ishikawa 9200293, Japan.
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NR 51
TC 68
Z9 77
U1 0
U2 9
PU NATL INST INDUSTRIAL HEALTH
PI KAWASAKI KANAGAWA
PA 21-1 NAGAO 6-CHOME TAMA-KU, KAWASAKI KANAGAWA, 214, JAPAN
SN 0019-8366
J9 IND HEALTH
JI Ind. Health
PD JAN
PY 2004
VL 42
IS 1
BP 41
EP 49
DI 10.2486/indhealth.42.41
PG 9
WC Environmental Sciences; Public, Environmental & Occupational Health;
   Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health; Toxicology
GA 767QU
UT WOS:000188464800006
PM 14964617
OA Bronze
DA 2025-06-11
ER

PT J
AU Yaghoubi, M
   Arefi, SH
   Assadi, M
AF Yaghoubi, M.
   Arefi, S. H.
   Assadi, M.
TI Comparison of angiographic with myocardial perfusion scintigraphy
   findings in cardiac syndrome X (CSX)
SO EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
LA English
DT Article
DE Cardiac syndrome; Angiography; Myocardial perfusion imaging
ID NORMAL CORONARY ARTERIOGRAMS; LEFT-VENTRICULAR FUNCTION; CHEST-PAIN;
   ESTROGEN DEFICIENCY; ANGINA-PECTORIS; ARTERIES; WOMEN
AB Objective: Cardiac syndrome X (CSX) is defined by an angina-like chest pain, a positive response to stress testing and normal or near normal coronary angiogram. We evaluated the angiographic findings in patients with cardiac syndrome X and compared it with myocardial perfusion scintigraphy findings.
   Patients and Methods: The study included 39 females aged 40-58 years (mean, 49.79 +/- 4.69 [SD] and 13 males ranging from 40 to 54 years (mean, 47.54 +/- 3.76 [SD] with CSX. By reviewing the angiographic film, some variables including stenosis (less than 30% of vessel diameter), delay run off, delay wash out, calcification and tortuosity were evaluated. Thirty-two had been undergone on myocardial perfusion imaging (MPI).
   Results: The most frequent abnormal angiographic finding in three territories was stenosis item. Overall, 22 of 32 (68.75%) CSX patients had ischemia on MPI. The result of the myocardial perfusion imaging was not concordant with five angiographic findings.
   Conclusion: We suggest that the presence of angiographic coronary findings such as stenosis, delay run off, delay wash out, calcification and tortuosity are not invariably associated with atherosclerosis, and also seen in CSX patients.
C1 [Assadi, M.] Bushehr Univ Med Sci, Persian Gulf Nucl Med Res Ctr, Bushehr, Iran.
   [Yaghoubi, M.; Arefi, S. H.] Univ Tehran Med Sci, Shariati Hosp, Dept Cardiol, Tehran, Iran.
C3 Tehran University of Medical Sciences
RP Assadi, M (corresponding author), Bushehr Univ Med Sci, Persian Gulf Nucl Med Res Ctr, Bushehr, Iran.
EM assadipoya@yahoo.com
RI Assadi, Majid/U-5316-2019; Assadi, Majid/H-2812-2017
OI Assadi, Majid/0000-0003-3862-9472
FU Tehran University of Medical Sciences
FX This study was the postgraduate thesis of Dr. Mohammad Yaghoubi for
   residency of Cardiology and was carried out with the sponsorship of
   Tehran University of Medical Sciences.
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NR 20
TC 5
Z9 5
U1 0
U2 0
PU VERDUCI PUBLISHER
PI ROME
PA VIA GREGORIO VII, ROME, 186-00165, ITALY
SN 1128-3602
J9 EUR REV MED PHARMACO
JI Eur. Rev. Med. Pharmacol. Sci.
PD DEC
PY 2011
VL 15
IS 12
BP 1385
EP 1388
PG 4
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 875IB
UT WOS:000299022500004
PM 22288299
DA 2025-06-11
ER

PT J
AU Stenholm, S
   Suorsa, K
   Leskinen, T
   Myllyntausta, S
   Pulakka, A
   Pentti, J
   Vahtera, J
AF Stenholm, Sari
   Suorsa, Kristin
   Leskinen, Tuija
   Myllyntausta, Saana
   Pulakka, Anna
   Pentti, Jaana
   Vahtera, Jussi
TI Finnish Retirement and Aging Study: a prospective cohort study
SO BMJ OPEN
LA English
DT Article
DE Aging; OCCUPATIONAL & INDUSTRIAL MEDICINE; PREVENTIVE MEDICINE; PUBLIC
   HEALTH; EPIDEMIOLOGIC STUDIES
ID LOWER-EXTREMITY FUNCTION; PHYSICAL-ACTIVITY TYPES; OLDER-ADULTS; HEALTH;
   PROFILE; ASSOCIATION; DISABILITY; MOBILITY; FITNESS; BATTERY
AB Purpose The Finnish Retirement and Aging (FIREA) Study was set up to study changes in health behavioural and cardiometabolic risk factors across retirement transition, and to examine the long-term consequences of work and retirement on health and functioning with advancing age. Participants Public sector workers whose estimated statutory retirement date was in 2014-2019 were invited to participate by sending them a questionnaire 18 months prior to their estimated retirement date. In the first phase of the FIREA Study, participants were followed up with annual surveys, accelerometer and clinical measurements during retirement transition into post-retirement years. The FIREA survey cohort includes 6783 participants, of which 908 belong also to the activity substudy and 290 to the clinical substudy. Findings to date Collected data include survey measures about health, lifestyle factors, psychosocial distress, work-related factors as well as retirement intentions. Accelerometer and GPS devices are used to measure 24-hour movement behaviours. Clinical examination includes blood and hair sample, measurements of anthropometry, cardiovascular function, physical fitness, physical and cognitive function. Our results suggest that in general retirement transition seems to have beneficial influence on health behaviours as well as on physical and mental health, but there are large individual differences, and certain behaviours such as sedentariness tend to increase especially among those retiring from manual occupations. Future plans The second phase of the FIREA Study will be conducted during 2023-2025, when participants are 70 years old. The FIREA Study welcomes research collaboration proposals that fall within the general aims of the project.
C1 [Stenholm, Sari; Suorsa, Kristin; Leskinen, Tuija; Pentti, Jaana; Vahtera, Jussi] Univ Turku, Dept Publ Hlth, Turku, Finland.
   [Stenholm, Sari; Suorsa, Kristin; Leskinen, Tuija; Pentti, Jaana; Vahtera, Jussi] Univ Turku, Ctr Populat Hlth Res, Turku, Finland.
   [Stenholm, Sari] Turku Univ Hosp, Res Serv, Turku, Finland.
   [Myllyntausta, Saana] Dept Psychol & Speech Language Pathol, Turun Yliopisto, Turku, Finland.
   [Pulakka, Anna] Univ Oulu, Fac Med, Res Unit Populat Hlth, Oulu, Finland.
   [Pulakka, Anna] Finnish Inst Hlth & Welf, Populat Hlth Unit, Helsinki, Finland.
   [Pentti, Jaana] Univ Helsinki, Fac Med, Clinicum, Helsinki, Finland.
C3 University of Turku; University of Turku; University of Turku;
   University of Oulu; University of Helsinki
RP Stenholm, S (corresponding author), Univ Turku, Dept Publ Hlth, Turku, Finland.; Stenholm, S (corresponding author), Univ Turku, Ctr Populat Hlth Res, Turku, Finland.; Stenholm, S (corresponding author), Turku Univ Hosp, Res Serv, Turku, Finland.
EM sari.stenholm@utu.fi
RI Stenholm, Sari/G-6940-2011; Vahtera, Jussi/J-3271-2013; Pulakka,
   Anna/HKM-8817-2023
OI Vahtera, Jussi/0000-0002-6036-061X; Leskinen, Tuija/0000-0001-7499-6128;
   Myllyntausta, Saana/0000-0002-6503-3829; Suorsa,
   Kristin/0000-0002-3520-8069
FU Academy of Finland [264944, 286294, 294154, 319246, 332030]; Ministry of
   Education and Culture; Hospital District of Southwest Finland; Finnish
   State Grants for Clinical Research; Finnish Work Environment Fund
   [118060]; Juho Vainio Foundation; Signe and Ane Gyllenberg Foundation;
   Paivikki and Sakari Sohlberg Foundation; Finnish Foundation for
   Cardiovascular Research
FX The FIREA Study has been financially supported by Academy of Finland
   (264944, 286294, 294154, 319246 and 332030); Ministry of Education and
   Culture; Hospital District of Southwest Finland, Finnish State Grants
   for Clinical Research; Finnish Work Environment Fund (118060); Juho
   Vainio Foundation; Signe and Ane Gyllenberg Foundation, Paivikki and
   Sakari Sohlberg Foundation and The Finnish Foundation for Cardiovascular
   Research
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NR 55
TC 7
Z9 7
U1 0
U2 3
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2044-6055
J9 BMJ OPEN
JI BMJ Open
PD DEC
PY 2023
VL 13
IS 12
AR e076976
DI 10.1136/bmjopen-2023-076976
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA JD0Z4
UT WOS:001171115000064
PM 38072496
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Vanni, R
   Bussuan, RM
   Rombaldi, RL
   Arbex, AK
AF Vanni, Rafael
   Bussuan, Renata Maksoud
   Rombaldi, Renato Luiz
   Arbex, Alberto K.
TI Endocrine Disruptors and the Induction of Insulin Resistance
SO CURRENT DIABETES REVIEWS
LA English
DT Review
DE endocrine disruptors; insulin resistance; bisphenol A; obesity;
   environmental pollutants; anamnesis
ID PERSISTENT ORGANIC POLLUTANTS; BISPHENOL-A LEVELS; PRECAUTIONARY
   PRINCIPLE; PUBLIC-HEALTH; DEVELOPMENTAL EXPOSURE; ENVIRONMENTAL-HEALTH;
   GLUCOSE-INTOLERANCE; PRIMARY PREVENTION; OXIDATIVE STRESS; DIETARY
   EXPOSURE
AB Introduction: The incidence of insulin resistance syndrome and type 2 diabetes mellitus has increased at an alarming rate worldwide and constitutes a serious challenge to public health care in the 21st century. Endocrine disrupting chemicals are defined as "substances or mixtures of substances that alter the endocrine system functions and, hence, adversely affect organisms, their progeny, or sub populations" and may be associated with this increase in prevalence.
   Objective: This study aimed to assess the role of endocrine disrupting chemicals in insulin resis-tance and the importance of approaching the subject during anamnesis.
   Methods: A full review of the literature regarding insulin resistance, type-2 diabetes and endocrine disruptors were conducted.
   Conclusion: Large-scale production and distribution of endocrine disrupting chemicals coincide with the increase in the prevalence of insulin resistance globally. In recent years, studies have shown that endocrine disrupting chemicals are positively associated with insulin resistance syn-drome, evidenced by worse prognoses among individuals with higher levels of exposure. Health professionals should recognize the forms of exposure, most susceptible people, and lifestyle habits that can worsen patients' prognoses.
C1 [Vanni, Rafael; Bussuan, Renata Maksoud; Rombaldi, Renato Luiz; Arbex, Alberto K.] IPEMED Med School, AFYA Educ, Rio De Janeiro, Brazil.
   [Vanni, Rafael; Rombaldi, Renato Luiz] UCS Univ Caxias Sul, Rio Grande do Sul, Brazil.
   [Arbex, Alberto K.] Med Clin, Schmallenberg, Germany.
RP Arbex, AK (corresponding author), IPEMED Med School, AFYA Educ, Rio De Janeiro, Brazil.; Arbex, AK (corresponding author), Med Clin, Schmallenberg, Germany.
EM albertoarbex@gmail.com
RI Arbex, Alberto/A-6226-2015
OI Krayyem Arbex, Alberto/0000-0002-0290-8923
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NR 150
TC 13
Z9 16
U1 4
U2 15
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1573-3998
EI 1875-6417
J9 CURR DIABETES REV
JI Curr. Diabetes Reviews
PY 2021
VL 17
IS 7
AR e102220187107
DI 10.2174/1573399816666201022121254
PG 14
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA WK2YB
UT WOS:000709595400010
PM 33092513
DA 2025-06-11
ER

PT J
AU Varghese, DS
   Ali, BR
AF Varghese, Divya Saro
   Ali, Bassam R.
TI Pathological Crosstalk Between Oxidized LDL and ER Stress in Human
   Diseases: A Comprehensive Review
SO FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
LA English
DT Review
DE ER stress sensors; UPR arm; human disease; HDL; oxidized LDL; therapy
ID ENDOPLASMIC-RETICULUM STRESS; LOW-DENSITY-LIPOPROTEIN; UNFOLDED PROTEIN
   RESPONSE; COENZYME-A REDUCTASE; FOAM CELL-FORMATION; OXIDATIVE STRESS;
   CHOLESTEROL-SYNTHESIS; ADIPOSE-TISSUE; SQUALENE MONOOXYGENASE; METABOLIC
   SYNDROME
AB The oxidative modification of the major cholesterol carrying lipoprotein, oxLDL, is a biomarker as well as a pathological factor in cardiovascular diseases (CVD), type 2 diabetes mellitus (T2DM), obesity and other metabolic diseases. Perturbed cellular homeostasis due to physiological, pathological and pharmacological factors hinder the proper functioning of the endoplasmic reticulum (ER), which is the major hub for protein folding and processing, lipid biosynthesis and calcium storage, thereby leading to ER stress. The cellular response to ER stress is marked by a defensive mechanism called unfolded protein response (UPR), wherein the cell adapts strategies that favor survival. Under conditions of excessive ER stress, when the survival mechanisms fail to restore balance, UPR switches to apoptosis and eliminates the defective cells. ER stress is a major hallmark in metabolic syndromes such as diabetes, non-alcoholic fatty liver disease (NAFLD), neurological and cardiovascular diseases. Though the pathological link between oxLDL and ER stress in cardiovascular diseases is well-documented, its involvement in other diseases is still largely unexplored. This review provides a deep insight into the common mechanisms in the pathogenicity of diseases involving oxLDL and ER stress as key players. In addition, the potential therapeutic intervention of the targets implicated in the pathogenic processes are also explored.
C1 [Varghese, Divya Saro; Ali, Bassam R.] United Arab Emirates Univ, Coll Med & Hlth Sci, Dept Genet & Genom, Al Ain, U Arab Emirates.
   [Ali, Bassam R.] United Arab Emirates Univ, Zayed Bin Sultan Ctr Hlth Sci, Al Ain, U Arab Emirates.
C3 United Arab Emirates University; United Arab Emirates University
RP Ali, BR (corresponding author), United Arab Emirates Univ, Coll Med & Hlth Sci, Dept Genet & Genom, Al Ain, U Arab Emirates.; Ali, BR (corresponding author), United Arab Emirates Univ, Zayed Bin Sultan Ctr Hlth Sci, Al Ain, U Arab Emirates.
EM bassam.ali@uaeu.ac.ae
RI ; Ali, Bassam R/J-7014-2012
OI Varghese, Divya Saro/0000-0002-6031-1084; Ali, Bassam
   R/0000-0003-1306-6618
FU UAEU Post Doc-Zayed Center [31R243, 12R084]
FX This work was supported by UAEU Post Doc-Zayed Center Grant for a period
   of 2 years (Grant Nos. 31R243 and 12R084).
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NR 252
TC 30
Z9 30
U1 2
U2 13
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-634X
J9 FRONT CELL DEV BIOL
JI Front. Cell. Dev. Biol.
PD MAY 26
PY 2021
VL 9
AR 674103
DI 10.3389/fcell.2021.674103
PG 19
WC Cell Biology; Developmental Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Developmental Biology
GA SO6NC
UT WOS:000659086500001
PM 34124059
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Wagner, J
   Naranjo, D
   Khun, T
   Seng, S
   Horn, IS
   Suttiratana, SC
   Keuky, L
AF Wagner, Julie
   Naranjo, Diana
   Khun, Touch
   Seng, Serey
   Horn, Ien S.
   Suttiratana, Sakinah C.
   Keuky, Lim
TI Diabetes and cardiometabolic risk factors in Cambodia: Results from two
   screening studies
SO JOURNAL OF DIABETES
LA English
DT Article
DE Cambodia; comorbidities; urban
ID MENTAL-HEALTH; PREVALENCE; ADULTS; METAANALYSIS; DISEASE
AB BackgroundDespite growing attention to diabetes throughout Asia, data from Southeast Asia are limited. This article reports rates of diabetes, hypertension, and obesity in Cambodia.
   MethodsTwo studies were conducted across different regions of Cambodia: (i) a 2012 screening study across urban, semi-urban, and rural areas that used point-of-care capillary glucose for determination of diabetes (n=13997); and (ii) a 2005 epidemiological study with random selection from two main urban areas that used oral glucose tolerance tests for determination of diabetes (n=1863). Blood pressure and anthropometrics were also measured.
   ResultsIn the screening study, rates of diabetes were significantly higher in urban than rural sites, with intermediate rates in semi-urban areas. There was a significant dose-response effect for urbanicity on overweight, obesity, and waist:hip ratio, with higher rates for urban versus semi-urban and for semi-urban versus rural locales. Rural sites had the lowest rates of hypertension, followed by urban and semi-urban sites. Among people who screened positive for diabetes, there was a dose-response effect for urbanicity on undiagnosed diabetes; rates of previously undiagnosed diabetes were lowest in urban (51%), followed by semi-urban (55%) and rural (67%) locales. Rural participants reported the highest rates of smoking and alcohol use. In the urban epidemiological study, prevalence rates of diabetes and impaired glucose tolerance were approximately 10%, indicating a prevalence of total glucose intolerance of approximately 20%.
   ConclusionsIn Cambodia, diabetes rates are high among urban residents and undiagnosed diabetes is highest among rural residents. A country-wide public health response is urgently needed; as development continues, rates of diabetes are expected to rise.
C1 [Wagner, Julie] Univ Connecticut, Sch Med, Dept Behav Sci & Community Hlth, Farmington, CT USA.
   [Wagner, Julie] Univ Connecticut, Sch Dent Med, Dept Behav Sci & Community Hlth, Farmington, CT 06032 USA.
   [Naranjo, Diana; Suttiratana, Sakinah C.] Stanford Univ, Sch Med, Dept Pediat Endocrinol & Diabet, Palo Alto, CA 94304 USA.
   [Suttiratana, Sakinah C.] Univ Calif San Francisco, Dept Social & Behav Sci, San Francisco, CA USA.
   [Khun, Touch; Seng, Serey; Horn, Ien S.; Keuky, Lim] Cambodian Diabet Assoc, Siem Reap, Cambodia.
C3 University of Connecticut; University of Connecticut; Stanford
   University; University of California System; University of California
   San Francisco
RP Wagner, J (corresponding author), UConn Hlth, Dept Behav Sci & Community Hlth, MC3910,263 Farmington Ave, Farmington, CT 06030 USA.
EM juwagner@uchc.edu
OI Suttiratana, Sakinah/0000-0001-9775-7736
FU Centre European d'Etude du Diabetes (Strasbourg, France); Medecins Sans
   Frontieres (Belgium); Servier International offices in Paris and Phnom
   Penh, WHO national and regional offices; International Diabetes
   Federation
FX On behalf of the Cambodian Diabetes Association, this manuscript is
   dedicated to our dear friend and colleague, the late Hilary KING. The
   2004 epidemiological study would not have been possible without his
   creativity, expertise, hard work, and commitment. Sadly, he passed away
   soon after the project was completed. His contribution to understanding
   diabetes in Cambodia is just one example of his life-long commitment to
   public health in the developing world. As scientists, we are deeply
   indebted to him. As friends, we miss him dearly. This research was
   conceived and conducted by the Cambodian Diabetes Association, and was
   made possible by direct cooperation between the Association and the
   Ministry of Health of Cambodia. Financial, technical and logistical
   support was provided by the Centre European d'Etude du Diabetes
   (Strasbourg, France), Medecins Sans Frontieres (Belgium), the Servier
   International offices in Paris and Phnom Penh, WHO national and regional
   offices, and the International Diabetes Federation. The Cambodian staff
   of Project Hope also offered endorsement and encouragement. No other
   funding was received. The sponsors had no role in study design, data
   collection, data analysis, data interpretation, or writing of the
   report. The Cambodian Diabetes Association had full access to all the
   data in the study and the corresponding author had final responsibility
   for the decision to submit for publication.
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NR 26
TC 5
Z9 5
U1 0
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1753-0393
EI 1753-0407
J9 J DIABETES
JI J. Diabetes
PD FEB
PY 2018
VL 10
IS 2
BP 148
EP 157
DI 10.1111/1753-0407.12570
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA FX1QZ
UT WOS:000425828100008
PM 28544429
DA 2025-06-11
ER

PT J
AU Chen, E
   Turiano, NA
   Mroczek, DK
   Miller, GE
AF Chen, Edith
   Turiano, Nicholas A.
   Mroczek, Daniel K.
   Miller, Gregory E.
TI Association of Reports of Childhood Abuse and All-Cause Mortality Rates
   in Women
SO JAMA PSYCHIATRY
LA English
DT Article
ID PHYSICAL ABUSE; PSYCHOLOGICAL VIOLENCE; METABOLIC SYNDROME;
   MENTAL-HEALTH; UNITED-STATES; RISK-FACTOR; EXPERIENCES; DISORDERS;
   ADULTHOOD; DEATH
AB IMPORTANCE Research has linked childhood abuse to a variety of adult psychiatric problems, but little is known about associations of child abuse with adult mortality.
   OBJECTIVE To test associations of retrospective reports of physical and emotional abuse in childhood with all-cause mortality rates in adulthood.
   DESIGN, SETTING, AND PARTICIPANTS National sample of 6285 adults (aged 25-74 years at baseline) from the survey of Midlife Development in the United States. Baseline psychosocial data were collected in 1995 and 1996, with follow-up mortality data collected through October 2015.
   MAIN OUTCOMES AND MEASURES Participants completed questionnaires at baseline about self-report of childhood emotional abuse, moderate physical abuse, and severe physical abuse. Mortality data during the next 20 years was tracked using the National Death Index.
   RESULTS Of the 6285 participants included in the study sample, 2987 were men (48%) and 5581 were white (91%), with a mean (SD) age of 46.9 (12.95) years. Women who reported childhood emotional abuse (hazard ratio [HR], 1.22; 95% CI, 1.01-1.49; P = .04), moderate physical abuse (HR, 1.30; 95% CI, 1.05-1.60; P = .02), or severe physical abuse (HR, 1.58; 95% CI, 1.20-2.08; P = .001) were at increased risk for all-cause mortality during the follow-up period. Reports of more types of childhood abuse were also associated with a greater risk of all-cause mortality in women (all vs none HR, 1.68; 95% CI, 1.24-2.30; P = .001; some vs none HR, 1.24; 95% CI, 1.01-1.52; P = .04). These effects could not be accounted for by childhood socioeconomic status, personality traits, or adult depression. No associations were observed in men.
   CONCLUSIONS AND RELEVANCE These results suggest that in addition to the established psychiatric consequences of abuse, women who report childhood abuse also remain vulnerable to premature mortality into adulthood. Thus, reported childhood abuse may have long-term ramifications for health and longevity in women.
C1 [Chen, Edith; Mroczek, Daniel K.; Miller, Gregory E.] Northwestern Univ, Dept Psychol, Evanston, IL USA.
   [Chen, Edith; Miller, Gregory E.] Northwestern Univ, Inst Policy Res, 2029 Sheridan Rd, Evanston, IL 60208 USA.
   [Turiano, Nicholas A.] Western Virginia Univ, Dept Psychol, Morgantown, WV USA.
   [Mroczek, Daniel K.] Northwestern Univ, Dept Med Social Sci, Evanston, IL USA.
C3 Northwestern University; Northwestern University; Northwestern
   University
RP Chen, E (corresponding author), Northwestern Univ, Dept Psychol, Evanston, IL USA.; Chen, E (corresponding author), Northwestern Univ, Inst Policy Res, 2029 Sheridan Rd, Evanston, IL 60208 USA.
EM edith.chen@northwestern.edu
OI Miller, Gregory/0000-0002-7217-1082; Turiano,
   Nicholas/0000-0002-2266-2959
FU National Institute on Aging [AG020166, AG018436]
FX This study was supported by grants AG020166 and AG018436 from the
   National Institute on Aging.
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NR 38
TC 98
Z9 111
U1 0
U2 13
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 2168-622X
EI 2168-6238
J9 JAMA PSYCHIAT
JI JAMA Psychiatry
PD SEP
PY 2016
VL 73
IS 9
BP 920
EP 927
DI 10.1001/jamapsychiatry.2016.1786
PG 8
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA DW9PB
UT WOS:000383992300009
PM 27540997
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU de la Monte, SM
AF de la Monte, Suzanne M.
TI Type 3 diabetes is sporadic Alzheimer's disease: Mini-review
SO EUROPEAN NEUROPSYCHOPHARMACOLOGY
LA English
DT Review
DE Insulin resistance; Diabetes; Glucose Metabolism; Alzheimer's;
   Nitrosamines
ID AMYLOID PRECURSOR PROTEIN; GROWTH-FACTOR EXPRESSION; CEREBRAL
   GLUCOSE-METABOLISM; INSULIN-RESISTANCE SYNDROME; BRAIN INSULIN;
   NONALCOHOLIC STEATOHEPATITIS; IN-VIVO; COGNITIVE IMPAIRMENT;
   SIGNAL-TRANSDUCTION; INTRANASAL INSULIN
AB Alzheimer's disease (AD) is the most common cause of dementia in North America. Growing evidence supports the concept that AD is a metabolic disease mediated by impairments in brain insulin responsiveness, glucose utilization, and energy metabolism, which lead to increased oxidative stress, inflammation, and worsening of insulin resistance. In addition, metabolic derangements directly contribute to the structural, functional, molecular, and biochemical abnormalities that characterize AD, including neuronal loss, synaptic disconnection, tau hyperphosphorylation, and amyloid -beta accumulation. Because the fundamental abnormalities in AD represent effects of brain insulin resistance and deficiency, and the molecular and biochemical consequences overlap with Type 1 and Type 2 diabetes, we suggest the term "Type 3 diabetes" to account for the underlying abnormalities associated with AD-type neurodegeneration. In light of the rapid increases in sporadic AD prevalence rates and vastly expanded use of nitrites and nitrates in foods and agricultural products over the past 30-40 years, the potential role of nitrosamine exposures as mediators of Type 3 diabetes is discussed. (C) 2014 Elsevier B.V. and ECNP. All rights reserved.
C1 [de la Monte, Suzanne M.] Brown Univ, Rhode Isl Hosp, Dept Med, Providence, RI 02903 USA.
   [de la Monte, Suzanne M.] Brown Univ, Rhode Isl Hosp, Dept Pathol, Providence, RI 02903 USA.
   [de la Monte, Suzanne M.] Brown Univ, Rhode Isl Hosp, Dept Neurol & Neurosurg, Providence, RI 02903 USA.
   [de la Monte, Suzanne M.] Brown Univ, Warren Alpert Med Sch, Providence, RI 02903 USA.
C3 Brown University; Lifespan Health Rhode Island; Rhode Island Hospital;
   Brown University; Lifespan Health Rhode Island; Rhode Island Hospital;
   Lifespan Health Rhode Island; Rhode Island Hospital; Brown University;
   Brown University
RP de la Monte, SM (corresponding author), Brown Univ, Rhode Isl Hosp, Dept Med, 55 Claverick St,Room 419, Providence, RI 02903 USA.
EM Suzanne_DeLaMonte_MD@Brown.edu
RI de la monte, suzanne/L-7670-2019
FU National Institutes of Health [AA11431, AA12908]
FX Supported by AA11431 and AA12908 from the National Institutes of Health.
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NR 90
TC 250
Z9 270
U1 0
U2 87
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0924-977X
EI 1873-7862
J9 EUR NEUROPSYCHOPHARM
JI Eur. Neuropsychopharmacol.
PD DEC
PY 2014
VL 24
IS 12
BP 1954
EP 1960
DI 10.1016/j.euroneuro.2014.06.008
PG 7
WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA AX7LJ
UT WOS:000347097200010
PM 25088942
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Putra, IGNE
   Wilkinson, S
   Daly, M
   Robinson, E
AF Putra, I. Gusti Ngurah Edi
   Wilkinson, Sam
   Daly, Michael
   Robinson, Eric
TI Risk of severe obesity development: Examining the role of psychological
   well-being related measures and sociodemographic factors in two
   longitudinal UK cohort studies
SO BRITISH JOURNAL OF HEALTH PSYCHOLOGY
LA English
DT Article
DE longitudinal study; mental health; psychological well-being; severe
   obesity; weight change
ID BODY-MASS INDEX; DEPRESSIVE SYMPTOMS; GENERAL-POPULATION; METABOLIC
   SYNDROME; LIFE SATISFACTION; WEIGHT STIGMA; ASSOCIATION; STRESS;
   CORTISOL; BMI
AB Objective To examine the prospective association between psychological well-being related measures and severe obesity development in young and middle-aged UK adults. Design A longitudinal analysis of two cohort studies. Methods We used data from the 1958 National Child Development Study (NCDS) and the 1970 British Cohort Study (BCS) to examine the association between baseline psychological well-being related measures (depressive symptoms, life satisfaction and self-efficacy) and severe obesity development (defined as body mass index - BMI >= 35 kg/m2) and residualized BMI change scores at follow-up. We analysed repeated measures of baseline and follow-up pairs with 6- to 7-year follow-up on average (n = 22,390 and 23,811 observations in NCDS and BCS, respectively) using panel data logistic and linear models controlling for sociodemographic factors. We conducted additional analyses using analytical sample sizes with longer follow-up (16-17 years). Results Although a range of sociodemographic factors (e.g., being female, non-married) were associated with increased risk of severe obesity development, we found limited evidence that psychological well-being related measures were associated with severe obesity development across cohorts and pooled analyses. Depressive symptoms, life satisfaction and self-efficacy were, however, associated with relatively small changes in continuous BMI change across analyses, and this tended to be limited to participants without obesity (BMI 18.5 to <30 kg/m2) and not those already living with obesity (BMI 30 to <35 kg/m2) at baseline. Conclusions There is limited evidence that psychological well-being related measures prospectively predict the development of severe obesity. Poorer psychological well-being is associated with modest changes in body weight in individuals without obesity.
C1 [Putra, I. Gusti Ngurah Edi] Univ Liverpool, Inst Populat Hlth, Dept Publ Hlth Policy & Syst, Whelan Bldg, Liverpool L69 3GB, England.
   [Wilkinson, Sam; Robinson, Eric] Univ Liverpool, Inst Populat Hlth, Dept Psychol, Liverpool, England.
   [Daly, Michael] Maynooth Univ, Dept Psychol, Maynooth, Ireland.
C3 University of Liverpool; University of Liverpool; Maynooth University
RP Putra, IGNE (corresponding author), Univ Liverpool, Inst Populat Hlth, Dept Publ Hlth Policy & Syst, Whelan Bldg, Liverpool L69 3GB, England.
EM i.gusti.ngurah.edi.putra@liverpool.ac.uk
FU Economic and Social Research Council
FX The Centre for Longitudinal Studies (CLS) at UCL and the UK Data Service
   provided access to NCDS and BCS datasets. Neither CLS nor the UK Data
   Service are responsible for the analysis or interpretation of the data
   presented in this work.
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NR 80
TC 0
Z9 0
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1359-107X
EI 2044-8287
J9 BRIT J HEALTH PSYCH
JI Br. J. Health Psychol.
PD MAY
PY 2025
VL 30
IS 2
AR e12798
DI 10.1111/bjhp.12798
PG 17
WC Psychology, Clinical
WE Social Science Citation Index (SSCI)
SC Psychology
GA 2ZF3O
UT WOS:001494828800005
PM 40256883
DA 2025-06-11
ER

PT J
AU He, YH
   Jiang, JP
   He, BH
   Shi, Z
AF He, Yinghua
   Jiang, Jianping
   He, Beihui
   Shi, Zheng
TI Chemical Activators of the Nrf2 Signaling Pathway in Nonalcoholic Fatty
   Liver Disease
SO NATURAL PRODUCT COMMUNICATIONS
LA English
DT Review
DE chemical activators; Nrf2; nonalcoholic fatty liver disease; ARE
ID CYCLOCARYA-PALIURUS; OXIDATIVE STRESS; PARKINSONS-DISEASE;
   LIPID-PEROXIDATION; MOUSE MODEL; ANTIOXIDANT; STEATOHEPATITIS; EXTRACT;
   NAFLD; MICE
AB Nonalcoholic fatty liver disease (NAFLD) is paralleling the insulin resistance andobesity epidemic and is regarded as liver metabolic syndrome, and its prevalence rate is increasing rapidly. The best explanation forthe occurrence and development of NAFLD is the "multiple hit" hypothesisinstead of the "two-hit" hypothesis. At present, NAFLD therapies are limited. Thenuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway is a keypathway in oxidative stress. Its downstream proteins/enzymes are regulated. Metabolic enzymes and antioxidant proteins/enzymes play a vital rolein cell defense protection and have attracted attention in the field of antioxidant research in recent years. Thispaper summarizes the regulatory mechanism of the Nrf2 signaling pathway and the research progress of Nrf2 activators in NAFLD to provide guidance for NAFLD therapy in the future.
C1 [He, Yinghua] Zhejiang Univ, Affiliated Hosp 1, Dept Clin Pharm, Sch Med, 79 Qingchun Rd, Hangzhou 310003, Zhejiang, Peoples R China.
   [Jiang, Jianping] Zhejiang Chinese Med Univ, Affiliated Hosp 1, Hangzhou, Peoples R China.
   [He, Beihui] Zhejiang Chinese Med Univ, Lab Digest Dis, Affiliated Hosp 1, Hangzhou, Peoples R China.
   [Shi, Zheng] Zhejiang Chinese Med Univ, Dept Pharm, Affiliated Hosp 1, Hangzhou, Peoples R China.
   [Shi, Zheng] Zhejiang Int Exchange Ctr Clin Tradit Chinese Med, Dept Pharm, Hangzhou, Peoples R China.
   [Shi, Zheng] Zhejiang Prov Hosp Tradit Chinese Med, Dept Pharm, St 9, Hangzhou 310081, Zhejiang, Peoples R China.
C3 Zhejiang University; Zhejiang Chinese Medical University; Zhejiang
   Chinese Medical University; Zhejiang Chinese Medical University;
   Zhejiang Chinese Medical University
RP He, YH (corresponding author), Zhejiang Univ, Affiliated Hosp 1, Dept Clin Pharm, Sch Med, 79 Qingchun Rd, Hangzhou 310003, Zhejiang, Peoples R China.; Shi, Z (corresponding author), Zhejiang Prov Hosp Tradit Chinese Med, Dept Pharm, St 9, Hangzhou 310081, Zhejiang, Peoples R China.
EM hyh735637773@zju.edu.cn; zjszyysz@163.com
FU Zhejiang Provincial Natural Science Foundation-Zhejiang Pharmaceutical
   Society Joint Fund [LYY18H280004, LY17H290007]; Special Research Project
   on Hospital Pharmacy of the Zhejiang Pharmaceutical Association
   [2018ZYY24]; National Natural Science Foundation of China [82074186];
   "Ten thousand plan"-high level talents special support plan of Zhejiang
   province, China [ZJWR0108035]
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: This
   project was supported by the Zhejiang Provincial Natural Science
   Foundation-Zhejiang Pharmaceutical Society Joint Fund (No. LYY18H280004,
   LY17H290007) and the Special Research Project on Hospital Pharmacy of
   the Zhejiang Pharmaceutical Association (2018ZYY24). This project was
   supported by the National Natural Science Foundation of China (Grant No.
   82074186). "Ten thousand plan"-high level talents special support plan
   of Zhejiang province, China (Grant No. ZJWR0108035).
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NR 69
TC 9
Z9 9
U1 5
U2 36
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1934-578X
EI 1555-9475
J9 NAT PROD COMMUN
JI Nat. Prod. Commun.
PD JAN
PY 2021
VL 16
IS 1
DI 10.1177/1934578X20987095
PG 9
WC Chemistry, Medicinal; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Food Science & Technology
GA PT8EB
UT WOS:000608843000001
OA gold
DA 2025-06-11
ER

PT S
AU Eleftheriades, M
   Creatsas, G
   Nicolaides, K
AF Eleftheriades, Makarios
   Creatsas, George
   Nicolaides, Kypros
BE Creatsas, G
   Mastorakos, G
   Chrousos, GP
TI Fetal growth restriction and postnatal development
SO WOMEN'S HEALTH AND DISEASE: GYNECOLOGIC, ENDOCRINE, AND REPRODUCTIVE
   ISSUES
SE Annals of the New York Academy of Sciences
LA English
DT Article; Proceedings Paper
CT 6th Athens Congress on Womens Health and Disease
CY SEP 23-25, 2005
CL Athens, GREECE
SP Athens Univ, Med Sch, Int Menopause Soc, European Menopause & Andropause Soc, Int Federat Gynecol & Obstet
DE fetal growth restriction; stress system; postnatal growth acceleration;
   metabolic syndrome
ID FOR-GESTATIONAL-AGE; BLOOD-GAS VALUES; LOW-BIRTH-WEIGHT; CATCH-UP
   GROWTH; PRENATAL STRESS; BIOPHYSICAL PROFILE; INSULIN-RESISTANCE;
   GLUCOSE-TOLERANCE; ADULT LIFE; OBESITY
AB The interaction between genetic constitution and in utero environment determines fetal growth and development and influences the susceptibility to certain disorders in adulthood. Data from both animal and human studies indicate that prenatal and early postnatal malnutrition can program the hypothalamus-pituitary-adrenal axis (HPA axis), altering neuroendocrine response to stressors throughout lifetime. Impaired uteroplacental perfusion results in fetal growth restriction (FGR). In FGR there is evidence of chronic hypoxemia and alterations in metabolic, endocrine, and hematological parameters, compatible with starvation. Furthermore, FGR is associated with increased perinatal mortality and in the survivors there is increased susceptibility to diabetes and cardiovascular disease in adulthood. There is evidence that early postnatal growth acceleration, which would normally be considered desirable, may exacerbate metabolic dysfunction in later life.
C1 Univ Athens, Sch Med, Aretaieio Hosp, Dept Obstet & Gynecol 2, GR-11527 Athens, Greece.
   Kings Coll Hosp London, Harris Birthright Res Ctr Fetal Med, London, England.
C3 National & Kapodistrian University of Athens; Athens Medical School;
   King's College Hospital NHS Foundation Trust; King's College Hospital;
   University of London; King's College London
RP Eleftheriades, M (corresponding author), 26 Haravgis St, Athens 15232, Greece.
EM makarios.eleftheriadis@kcl.ac.uk
OI Nicolaides, Kypros/0000-0003-1266-0711
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NR 67
TC 46
Z9 56
U1 0
U2 6
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN STREET, MALDEN 02148, MA USA
SN 0077-8923
BN 978-1-57331-621-7
J9 ANN NY ACAD SCI
JI Ann.NY Acad.Sci.
PY 2006
VL 1092
BP 319
EP 330
DI 10.1196/annals.1365.047
PG 12
WC Endocrinology & Metabolism; Multidisciplinary Sciences; Obstetrics &
   Gynecology
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Science & Technology - Other Topics;
   Obstetrics & Gynecology
GA BFZ47
UT WOS:000245624300028
PM 17308157
OA Bronze
DA 2025-06-11
ER

PT J
AU Salman, A
   Sellami, M
   AL-Mohannadi, AS
   Chun, S
AF Salman, Ahmad
   Sellami, Maha
   AL-Mohannadi, Abdulla Saeed
   Chun, Sungsoo
TI The Associations between Mental Well-Being and Adherence to Physical
   Activity Guidelines in Patients with Cardiovascular Disease: Results
   from the Scottish Health Survey
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Article
DE physical activity; mental well-being; health-related behavior
ID AMERICAN-HEART-ASSOCIATION; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   EXERCISE; RISK; DEPRESSION; PREVENTION; CHILDREN; CORONARY; FITNESS
AB The association between physical activity (PA) and mental well-being in individuals with a cardiovascular disease (CVD) is poorly studied. The objective of this study was to assess the association between mental well-being and adherence to the recommended guidelines for PA in a Scottish adult population with CVD. The study used data from 3128 adults who had CVD conditions (1547 men and 1581 women; mean age 63.29 years) who participated in the Scottish Health Survey between 2014 and 2017. The Warwick-Edinburgh Mental Well-Being Scale (WEMWBS) was used as a surrogate measure of mental health. PA was classified as "met" or "unmet" on the basis of the recommended PA guidelines (150 min of moderate activity or 75 min of vigorous activity per week). The relationship between PA guidelines being met and the WEMWBS score was explored using hierarchical linear regression accounting for a set of health and sociodemographic characteristics. Of the participants, similar to 41.8% met the recommended PA levels. Among those with CVD, the mean (SD) WEMWBS scores of individuals who did not have a long-standing illness (51.14 +/- 7.65 vs 47.07 +/- 9.54; p < 0.05), diabetes (48.44 +/- 9.05 vs 46.04 +/- 10.25; p < 0.05), or high blood pressure (48.63 +/- 9.08 vs 47.52 +/- 9.47; p < 0.05) were significantly higher than those of individuals with such conditions. Meeting PA recommendations was significantly associated with a higher mean WEMWBS score (50.64 +/- 7.97 vs 46.06 +/- 9.75; p < 0.05). Multiple regression analysis of health-related behaviors improved the prediction of mental well-being over and above meeting the recommended PA levels. Mental well-being was strongly correlated with PA adherence in CVD patients. It seems that for patients with CVD, PA should be tailored to meet patients' health conditions in order to promote mental well-being and improve overall health.
C1 [Salman, Ahmad] Qatar Univ, QU Hlth, Coll Hlth Sci, Doha 2713, Qatar.
   [Salman, Ahmad] Univ York, Dept Hlth Sci, York Y010 5DD, N Yorkshire, England.
   [Salman, Ahmad; Chun, Sungsoo] Kuwait Publ Policy Ctr, Gen Secretariat Supreme Council Planning & Dev, Safat 13001, Kuwait.
   [Sellami, Maha] Qatar Univ, CAS, SSP, Doha 2713, Qatar.
   [AL-Mohannadi, Abdulla Saeed] Aspetar Orthopaed & Sports Med Hosp, Res & Sci Support Dept, Doha 29222, Qatar.
C3 Qatar University; University of York - UK; Qatar University; Aspetar
   Orthopaedic & Sports Medicine Hospital
RP Salman, A (corresponding author), Qatar Univ, QU Hlth, Coll Hlth Sci, Doha 2713, Qatar.; Salman, A (corresponding author), Univ York, Dept Hlth Sci, York Y010 5DD, N Yorkshire, England.; Salman, A (corresponding author), Kuwait Publ Policy Ctr, Gen Secretariat Supreme Council Planning & Dev, Safat 13001, Kuwait.
EM as1816@york.ac.uk; msellami@qu.edu.qa; Abdulla.Almohannadi@aspetar.com;
   Chss9712@gmail.com
RI SALMAN, AHMAD/W-9646-2019
OI AL-MOHANNADI, ABDULLA SAEED/0000-0002-8342-8576; Chun,
   Sungsoo/0000-0002-8105-7062; Sellami, Maha/0000-0003-1832-409X; Salman,
   Ahmad/0000-0003-2204-3565
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NR 71
TC 8
Z9 8
U1 1
U2 5
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD OCT
PY 2019
VL 16
IS 19
AR 3596
DI 10.3390/ijerph16193596
PG 13
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA JK3MF
UT WOS:000494748600092
PM 31561424
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Sharma, A
   Tiwari, S
   Singaravel, M
AF Sharma, Arpita
   Tiwari, Shashank
   Singaravel, Muniyandi
TI Circadian rhythm disruption: health consequences
SO BIOLOGICAL RHYTHM RESEARCH
LA English
DT Article
DE Circadian rhythm; entrainment; SCN; jet lag; shift work; sleep disorders
ID NIGHT-SHIFT WORK; SLEEP-WAKE SYNDROME; CHRONIC JET-LAG; CLOCK
   GENE-EXPRESSION; OXIDATIVE STRESS; MELATONIN SECRETION; CARDIOVASCULAR
   CONSEQUENCES; OCCUPATIONAL STRESS; METABOLIC SYNDROME; LIGHT EXPOSURE
AB Circadian rhythms control many facets of biology and their disruption can be associated with severe pathological conditions. In healthy individuals, disturbances to the sleep-wake cycle can be the root cause of many problems. In the present review, we explore the major factors contributing to circadian rhythm disruption, including sleep disorders, jet lag, and shift work. The consequences of these disruptions on central and peripheral clocks and the important areas of the body controlled by them involve immune function and metabolism, as well as alterations in cognitive abilities, thereby impairing social and occupational behavior. Further work exploring clock genes, light exposure, and cellular changes will be critical for identifying how these factors interact to affect health and behavior.
C1 [Sharma, Arpita; Tiwari, Shashank; Singaravel, Muniyandi] Banaras Hindu Univ, Dept Zool, Chronobiol Lab, Varanasi 221005, Uttar Pradesh, India.
C3 Banaras Hindu University (BHU)
RP Singaravel, M (corresponding author), Banaras Hindu Univ, Dept Zool, Chronobiol Lab, Varanasi 221005, Uttar Pradesh, India.
EM m_singaravel@yahoo.com
FU DST, New Delhi [SR/CSI/157/2012, SB/EMEQ-106/2013]; UGC New Delhi
   [39-572/2010 (SR)]
FX This work was supported Financial aid to MS by DST, New Delhi [number
   SR/CSI/157/2012 & SB/EMEQ-106/2013]; UGC New Delhi [number 39-572/2010
   (SR)].
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NR 181
TC 15
Z9 18
U1 2
U2 127
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0929-1016
EI 1744-4179
J9 BIOL RHYTHM RES
JI Biol. Rhythm Res.
PD MAR 3
PY 2016
VL 47
IS 2
BP 191
EP 213
DI 10.1080/09291016.2015.1103942
PG 23
WC Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics; Physiology
GA DD6KV
UT WOS:000370034000002
DA 2025-06-11
ER

PT J
AU Könner, AC
   Brüning, JC
AF Koenner, A. Christine
   Bruening, Jens C.
TI Toll-like receptors: linking inflammation to metabolism
SO TRENDS IN ENDOCRINOLOGY AND METABOLISM
LA English
DT Review
ID INDUCED INSULIN-RESISTANCE; SATURATED FATTY-ACIDS; WHITE ADIPOSE-TISSUE;
   DIET-INDUCED OBESITY; KAPPA-B; LEPTIN RESISTANCE; EXPRESSING NEURONS;
   ENERGY-BALANCE; BODY-WEIGHT; IKK-BETA
AB Obesity has been characterized as a state of chronic inflammation. Inflammatory signaling not only causes peripheral insulin resistance, but also promotes neuronal insulin and leptin resistance, which further propagates a positive energy balance. Upon development of obesity, numerous conditions, including increased circulating cytokine concentrations and cell autonomous dysregulation of homeostatic signaling pathways, such as the endoplasmic reticulum stress response, promote activation of stress kinases, to cause peripheral insulin as well as central insulin and leptin resistance. Recently, activation of toll-like receptor (TLR) signaling has been recognized as an alternative activator of obesity-induced inflammation. In this paper, we review recent progress in defining the molecular basis of obesity-associated TLR activation and its role in the development of metabolic syndrome.
C1 [Koenner, A. Christine; Bruening, Jens C.] Univ Cologne, Dept Mouse Genet & Metab, Inst Genet, CMMC, D-50674 Cologne, Germany.
   [Koenner, A. Christine; Bruening, Jens C.] Max Planck Inst Biol Ageing, D-50674 Cologne, Germany.
   [Koenner, A. Christine; Bruening, Jens C.] Univ Hosp Cologne, Dept Internal Med 2, D-50924 Cologne, Germany.
C3 University of Cologne; Max Planck Society; University of Cologne
RP Brüning, JC (corresponding author), Univ Cologne, Dept Mouse Genet & Metab, Inst Genet, CMMC, D-50674 Cologne, Germany.
EM jens.bruening@uni-koeln.de
FU Center for Molecular Medicine (CMMC), University of Cologne [TVA1];
   European Community [FP7/2007-2013, 201608]; European Union
   [FP7-HEALTH-2009-241592]; DFG [BR 1492/7-1]; Federal Ministry of
   Education and Research [FKZ01GIO845]; Faculty of Medicine, University of
   Cologne
FX We apologize to all colleagues whose important contributions could not
   be cited because of space limitations. We thank G. Schmall and T. Rayle
   for excellent secretarial assistance. This work was supported by the
   Center for Molecular Medicine (CMMC), University of Cologne (TVA1 to
   J.C.B.), the European Community's Seventh Framework Program
   (FP7/2007-2013) under grant agreement number 201608 (TOBI), the European
   Union (FP7-HEALTH-2009-241592, EurOCHIP, to J.C.B.), the DFG (BR
   1492/7-1 to J.C.B.), the Competence Network for "Adipositas"
   (Neurotarget) funded by the Federal Ministry of Education and Research
   (FKZ01GIO845 to J.C.B.) and the Koeln Fortune Program, Faculty of
   Medicine, University of Cologne (to A.C.K.).
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Z9 297
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PA 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND
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EI 1879-3061
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SC Endocrinology & Metabolism
GA 715FJ
UT WOS:000286865700003
PM 20888253
DA 2025-06-11
ER

PT J
AU Xu, CM
   Yu, J
AF Xu, Chuanming
   Yu, Jun
TI Pathophysiological mechanisms of hypertension development induced by
   fructose consumption
SO FOOD & FUNCTION
LA English
DT Review
ID RENIN-ANGIOTENSIN SYSTEM; SERUM URIC-ACID; ELICITS INSULIN-RESISTANCE;
   NITRIC-OXIDE SYNTHASE; BLOOD-PRESSURE; METABOLIC SYNDROME; OXIDATIVE
   STRESS; PROGRAMMED HYPERTENSION; HIGH-SALT; DIETARY FRUCTOSE
AB During the past several decades, there has been a dramatic increase in fructose consumption worldwide in parallel with epidemics of metabolic diseases. Accumulating evidence has suggested that excessive fructose consumption is extensively linked to an increase in blood pressure. A combined intake of high fructose and high salt induced salt-sensitive hypertension and maternal high-fructose consumption induced programmed hypertension in adult offspring. The underlying mechanisms of these two events are similar and complex. These mainly include activation of the intrarenal renin-angiotensin system, gut dysbiosis, enhanced oxidative stress, activation of nephron ion transporters, and dysregulation of T-lymphocytes. The major objective of this article is to review recent advances in these fields and suggest novel therapies targeting these mechanisms that have potentially beneficial effects on diet-associated hypertension.
C1 [Xu, Chuanming] Jiangxi Univ Chinese Med, Translat Med Ctr, Nanchang 330002, Jiangxi, Peoples R China.
   [Yu, Jun] Temple Univ, Ctr Metab Dis Res, Lewis Katz Sch Med, Philadelphia, PA 19140 USA.
   [Yu, Jun] Temple Univ, Dept Physiol, Lewis Katz Sch Med, Philadelphia, PA 19140 USA.
C3 Jiangxi University of Traditional Chinese Medicine; Pennsylvania
   Commonwealth System of Higher Education (PCSHE); Temple University;
   Pennsylvania Commonwealth System of Higher Education (PCSHE); Temple
   University
RP Xu, CM (corresponding author), Jiangxi Univ Chinese Med, Translat Med Ctr, Nanchang 330002, Jiangxi, Peoples R China.
EM xuchuanming2008@163.com
RI xu, chuanming/ABH-9190-2020
OI xu, chuanming/0000-0001-7082-2833
FU Jiangxi "Double thousand plan" [jxsq2020101074]; National Natural
   Science Foundation of China [82160051, 32100908]; Jiangxi Provincial
   Natural Science Foundation [20212BAB216005]; PhD Start-up Research Fund
   of the Jiangxi University of Chinese Medicine [2020BSZR009]; Jiangxi Key
   Laboratory grant of the Science and Technology Department of Jiangxi
   Province [20202BCD42014]; Science and Technology Research Project of the
   Education Department of Jiangxi Province [GJJ201262]
FX This work was supported by grants from Jiangxi "Double thousand plan"
   (No. jxsq2020101074), the National Natural Science Foundation of China
   (No. 82160051 and 32100908), the Jiangxi Provincial Natural Science
   Foundation (No. 20212BAB216005), the PhD Start-up Research Fund of the
   Jiangxi University of Chinese Medicine (No. 2020BSZR009), the Jiangxi
   Key Laboratory grant of the Science and Technology Department of Jiangxi
   Province (No. 20202BCD42014), and the Science and Technology Research
   Project of the Education Department of Jiangxi Province (No. GJJ201262).
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NR 173
TC 8
Z9 8
U1 3
U2 36
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PD FEB 21
PY 2022
VL 13
IS 4
BP 1702
EP 1717
DI 10.1039/d1fo03381f
EA JAN 2022
PG 16
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA ZD5TM
UT WOS:000750362600001
PM 35113090
DA 2025-06-11
ER

PT J
AU Bullon, P
   Newman, HN
   Battino, M
AF Bullon, Pedro
   Newman, Hubert N.
   Battino, Maurizio
TI Obesity, diabetes mellitus, atherosclerosis and chronic periodontitis: a
   shared pathology via oxidative stress and mitochondrial dysfunction?
SO PERIODONTOLOGY 2000
LA English
DT Article
ID METABOLIC SYNDROME; REACTIVE OXYGEN; FREE-RADICALS; ANTIOXIDANT
   CAPACITY; PANCREATIC-ISLETS; GINGIVAL TISSUE; DNA-DAMAGE; COENZYME-Q;
   AUTOPHAGY; ASSOCIATION
AB As many diseases have been shown to have several or indirect causes (i.e. are multifactorial) the question is what is the relative importance of each factor in a given disease? Also, what happens when some diseases, although apparently disparate, share causative factors and/or tissue pathologies? Host inflammation response mechanisms are largely shared by the body's different tissues and systems and only recently has special attention been paid to the possible linkages among chronic periodontitis and other chronic systemic diseases. The aim of this review was to consider and discuss the mounting evidence that the basis for the inter-relationships between chronic periodontitis and atheromatous disease and diabetes lie at a fundamental intracellular level, namely oxidative stress and mitochondrial dysfunction, as a meeting background among such chronic diseases and periodontitis.
RI Battino, Maurizio/E-6103-2012; Bullon, Pedro/E-6319-2010
OI Battino, Maurizio/0000-0002-7250-1782; Bullon, Pedro/0000-0003-4873-4196
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NR 99
TC 209
Z9 238
U1 3
U2 113
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0906-6713
EI 1600-0757
J9 PERIODONTOL 2000
JI Periodontol. 2000
PD FEB
PY 2014
VL 64
IS 1
BP 139
EP 153
DI 10.1111/j.1600-0757.2012.00455.x
PG 15
WC Dentistry, Oral Surgery & Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dentistry, Oral Surgery & Medicine
GA 268FX
UT WOS:000328156500009
PM 24320961
DA 2025-06-11
ER

PT J
AU Nguyen, HTL
   Panyoyai, N
   Kasapis, S
   Pang, E
   Mantri, N
AF Huong Thi Lan Nguyen
   Panyoyai, Naksit
   Kasapis, Stefan
   Pang, Edwin
   Mantri, Nitin
TI Honey and Its Role in Relieving Multiple Facets of Atherosclerosis
SO NUTRIENTS
LA English
DT Review
DE Honey; composition; antioxidants; atherosclerosis; inflammation;
   oxidative stress; cholesterol
ID RADICAL SCAVENGING ACTIVITY; ANTIOXIDANT ACTIVITY; OXIDATIVE STRESS;
   NATURAL HONEY; CLOSTRIDIUM-BOTULINUM; BOTANICAL ORIGIN; IN-VITRO;
   PHYSICOCHEMICAL CHARACTERISTICS; CHEMICAL-COMPOSITION; METABOLIC
   SYNDROME
AB Honey, a natural sweetener has been used universally as a complete food and in complementary medicine since early antiquity. Honey contains over 180 substances, including sugars mainly fructose and glucose, water and a plethora of minor constituents such as vitamins, minerals and phytochemicals. The chemical composition of honey varies depending on floral origin, environment and geographical conditions. The sugar components dominate honey composition and they are accountable for sensory and physicochemical properties in food industry. Although present in small quantities, non-sugar components are the major contributors to the health benefits of honey. Our review summarizes and discusses composition of honey, its protective effects and possible action modes on risk factors of atherosclerosis.
C1 [Huong Thi Lan Nguyen; Kasapis, Stefan; Pang, Edwin; Mantri, Nitin] RMIT Univ, Sch Sci, Pangen Lab, Melbourne, Vic 3083, Australia.
   [Huong Thi Lan Nguyen] Vietnam Inst Agr Engn & Postharvest Technol, Dept Sci, Hanoi 10000, Vietnam.
   [Panyoyai, Naksit] Rajabhat Chiang Mai Univ, Fac Agr Technol, Chiang Mai 50300, Thailand.
C3 Royal Melbourne Institute of Technology (RMIT); Chiang Mai Rajabhat
   University
RP Mantri, N (corresponding author), RMIT Univ, Sch Sci, Pangen Lab, Melbourne, Vic 3083, Australia.
EM ntlanhuong77@gmail.com; naksit_pan@cmru.ac.th;
   stefan.kasapis@rmit.edu.au; eddie.pang@rmit.edu.au;
   nitin.mantri@rmit.edu.au
RI Kasapis, Stefan/GRS-1908-2022
OI Mantri, Nitin/0000-0002-7621-035X; Kasapis, Stefan/0000-0003-2742-931X
FU RMIT University VIED Scholarship
FX This research received no external funding. HN received RMIT University
   VIED Scholarship for her PhD.
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NR 143
TC 49
Z9 49
U1 0
U2 30
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JAN
PY 2019
VL 11
IS 1
AR 167
DI 10.3390/nu11010167
PG 22
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA HJ8VI
UT WOS:000457477800012
PM 30646548
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Kanbay, M
   Segal, M
   Afsar, B
   Kang, DH
   Rodriguez-Iturbe, B
   Johnson, RJ
AF Kanbay, Mehmet
   Segal, Mark
   Afsar, Baris
   Kang, Duk-Hee
   Rodriguez-Iturbe, Bernardo
   Johnson, Richard J.
TI The role of uric acid in the pathogenesis of human cardiovascular
   disease
SO HEART
LA English
DT Review
ID IMPROVES ENDOTHELIAL FUNCTION; CORONARY-HEART-DISEASE;
   MUSCLE-CELL-PROLIFERATION; XANTHINE-OXIDASE INHIBITION;
   RENIN-ANGIOTENSIN SYSTEM; OXIDATIVE STRESS; BLOOD-PRESSURE;
   NITRIC-OXIDE; SERUM URATE; RISK-FACTOR
AB Hyperuricaemia is common in subjects with cardiovascular disease, but is not commonly considered a true risk factor. Recent studies suggest that uric acid is biologically active and can stimulate oxidative stress, endothelial dysfunction, inflammation and vasoconstriction. Epidemiological studies have found that uric acid can independently predict the development of hypertension, as well as stroke and heart failure. Experimentally raising uric acid in animals increases blood pressure, and pilot studies suggest that lowering uric acid in humans can reduce blood pressure in hypertensive individuals. Uric acid may also have emerging roles in the pathogenesis of kidney disease, metabolic syndrome and diabetes. More studies need to be performed on the pathophysiology and clinical consequences of hyperuricaemia in cardiovascular disease.
C1 [Kanbay, Mehmet] Medeniyet Univ, Sch Med, Dept Med, Div Nephrol, TR-03460 Istanbul, Turkey.
   [Segal, Mark] Univ Florida, Div Nephrol, Gainesville, FL USA.
   [Afsar, Baris] Konya Numune State Hosp, Dept Med, Div Nephrol, Konya, Turkey.
   [Kang, Duk-Hee] Ewha Womans Univ, Sch Med, Ewha Med Res Ctr, Dept Internal Med,Div Nephrol, Seoul, South Korea.
   [Rodriguez-Iturbe, Bernardo] Univ Hosp, Renal Serv, Maracaibo, Venezuela.
   [Johnson, Richard J.] Univ Colorado, Div Nephrol, Denver, CO 80202 USA.
C3 Istanbul Medeniyet University; State University System of Florida;
   University of Florida; Konya Numune Hospital; Ewha Womans University;
   University of Colorado System; University of Colorado Denver
RP Kanbay, M (corresponding author), Medeniyet Univ, Sch Med, Dept Med, Div Nephrol, TR-03460 Istanbul, Turkey.
EM drkanbay@yahoo.com
RI 1, 1/L-6277-2019
OI Segal, Mark/0000-0002-5502-2042
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NR 139
TC 346
Z9 373
U1 1
U2 122
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 1355-6037
EI 1468-201X
J9 HEART
JI Heart
PD JUN
PY 2013
VL 99
IS 11
BP 759
EP 766
DI 10.1136/heartjnl-2012-302535
PG 8
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 138CM
UT WOS:000318486000004
PM 23343689
DA 2025-06-11
ER

PT J
AU Li, C
   Li, J
   Jiang, F
   Tzvetkov, NT
   Horbanczuk, JO
   Li, YL
   Atanasov, AG
   Wang, DD
AF Li, Chao
   Li, Jie
   Jiang, Feng
   Tzvetkov, Nikolay T.
   Horbanczuk, Jaroslaw O.
   Li, Yunlun
   Atanasov, Atanas G.
   Wang, Dongdong
TI Vasculoprotective effects of ginger (Zingiber officinale Roscoe)
   and underlying molecular mechanisms
SO FOOD & FUNCTION
LA English
DT Review
ID CHEMOTHERAPY-INDUCED NAUSEA; FOAM CELL-FORMATION; PLATELET-AGGREGATION;
   OXIDATIVE STRESS; DOUBLE-BLIND; METABOLIC SYNDROME; LIPID PROFILE;
   KAPPA-B; ANTIPLATELET AGGREGATION; MESENCHYMAL TRANSITION
AB Ginger (Zingiber officinale Roscoe) is a common and widely used spice. It is rich in various chemical constituents, including phenolic compounds, terpenes, polysaccharides, lipids, organic acids, and raw fibers. Herein, we reviewed its effects on the vascular system. Studies utilizing cell cultures or animal models showed that ginger constituents alleviate oxidative stress and inflammation, increase nitric oxide synthesis, suppress vascular smooth muscle cell proliferation, promote cholesterol efflux from macrophages, inhibit angiogenesis, block voltage-dependent Ca2+ channels, and induce autophagy. In clinical trials, ginger was shown to have a favorable effect on serum lipids, inflammatory cytokines, blood pressure, and platelet aggregation. Taken together, these studies point to the potential benefits of ginger and its constituents in the treatment of hypertension, coronary artery disease, peripheral arterial diseases, and other vascular diseases.
C1 [Li, Chao; Li, Jie; Li, Yunlun] Shandong Univ Tradit Chinese Med, Expt Ctr, Jinan 250355, Peoples R China.
   [Jiang, Feng; Li, Yunlun] Shandong Univ Tradit Chinese Med, Affiliated Hosp, Dept Cardiol, Jinan 250000, Peoples R China.
   [Tzvetkov, Nikolay T.] Bulgarian Acad Sci, Inst Mol Biol Roumen Tsanev, Dept Biochem Pharmacol & Drug Design, Sofia, Bulgaria.
   [Horbanczuk, Jaroslaw O.; Atanasov, Atanas G.] Polish Acad Sci, Inst Genet & Anim Breeding, Dept Mol Biol, Ul Postepu 36A, PL-05552 Jastrzebiec, Poland.
   [Atanasov, Atanas G.] Med Univ Vienna, Ludwig Boltzmann Inst Digital Hlth & Patient Safe, Spitalgasse 23, A-1090 Vienna, Austria.
   [Atanasov, Atanas G.] Bulgarian Acad Sci, Inst Neurobiol, 23 Acad G Bonchevstr, Sofia 1113, Bulgaria.
   [Atanasov, Atanas G.] Univ Vienna, Dept Pharmacognosy, Althanstr 14, A-1090 Vienna, Austria.
   [Wang, Dongdong] McMaster Univ, Ctr Metab Obes & Diabet Res, Dept Med, Main St West 1280, Hamilton, ON L8S4L8, Canada.
C3 Shandong University of Traditional Chinese Medicine; Shandong University
   of Traditional Chinese Medicine; Bulgarian Academy of Sciences;
   Institute of Genetics & Animal Biotechnology, Polish Academy of
   Sciences; Polish Academy of Sciences; Medical University of Vienna;
   Bulgarian Academy of Sciences; University of Vienna; McMaster University
RP Li, YL (corresponding author), Shandong Univ Tradit Chinese Med, Expt Ctr, Jinan 250355, Peoples R China.; Li, YL (corresponding author), Shandong Univ Tradit Chinese Med, Affiliated Hosp, Dept Cardiol, Jinan 250000, Peoples R China.; Atanasov, AG (corresponding author), Polish Acad Sci, Inst Genet & Anim Breeding, Dept Mol Biol, Ul Postepu 36A, PL-05552 Jastrzebiec, Poland.; Atanasov, AG (corresponding author), Med Univ Vienna, Ludwig Boltzmann Inst Digital Hlth & Patient Safe, Spitalgasse 23, A-1090 Vienna, Austria.; Atanasov, AG (corresponding author), Bulgarian Acad Sci, Inst Neurobiol, 23 Acad G Bonchevstr, Sofia 1113, Bulgaria.; Atanasov, AG (corresponding author), Univ Vienna, Dept Pharmacognosy, Althanstr 14, A-1090 Vienna, Austria.; Wang, DD (corresponding author), McMaster Univ, Ctr Metab Obes & Diabet Res, Dept Med, Main St West 1280, Hamilton, ON L8S4L8, Canada.
EM yunlun.lee@hotmail.com; atanas.atanasov@univie.ac.at;
   dongdong.wang@usz.ch
RI Yang, Tian/JFB-1008-2023; Li, Chao/ABD-9324-2021; Horbanczuk,
   Jaroslaw/ABD-8389-2021; Wang, Dongdong/P-7257-2016; Atanasov,
   Atanas/C-5535-2013
OI Wang, Dongdong/0000-0002-6195-4428; Li, Chao/0000-0003-1568-9704;
   Atanasov, Atanas/0000-0003-2545-0967
FU National Nature Science Foundation of China [81974566, 82004276,
   82004277]; Shandong Provincial Natural Science Foundation [ZR2020QH305,
   ZR2020QH309]; China Postdoctoral Science Foundation [2020M672125];
   Taishan Scholar Post Construction Fund [ts201712042]
FX This work received support from the National Nature Science Foundation
   of China (81974566, 82004276, and 82004277), Shandong Provincial Natural
   Science Foundation (ZR2020QH305 and ZR2020QH309), China Postdoctoral
   Science Foundation (2020M672125) and Taishan Scholar Post Construction
   Fund (ts201712042).
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NR 129
TC 36
Z9 41
U1 11
U2 51
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PD MAR 7
PY 2021
VL 12
IS 5
BP 1897
EP 1913
DI 10.1039/d0fo02210a
PG 17
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA QW9RH
UT WOS:000628984700003
PM 33592084
DA 2025-06-11
ER

PT J
AU Lastra-Gonzalez, G
   Manrique-Acevedo, C
   Sowers, JR
AF Lastra-Gonzalez, Guido
   Manrique-Acevedo, Camila
   Sowers, James R.
TI The Role of Aldosterone in Cardiovascular Disease in People With
   Diabetes and Hypertension: An Update
SO CURRENT DIABETES REPORTS
LA English
DT Article
ID INSULIN-RECEPTOR SUBSTRATE-1; PLASMA-ALDOSTERONE; METABOLIC SYNDROME;
   DOWN-REGULATION; OXIDATIVE STRESS; NADPH OXIDASE; RESISTANCE;
   SENSITIVITY; EPLERENONE; PREVALENCE
AB The role of mineralocorticoids in the development of cardiovascular disease (CVD), cardiometabolic syndrome, type 2 diabetes mellitus, chronic kidney disease (CKD), hypertension, is a growing field of interest. Aldosterone, mainly through nongenomic actions that result in proliferation, fibrosis, inflammation, and tissue remodeling, has,been linked to CVD and CKD. Increased circulating aldosterone is also associated with insulin resistance and impaired glucose homeostasis that contribute to the development of endothelial dysfunction, atherosclerosis, and kidney disease. Aldosterone-induced oxidative stress and inflammation play a key role in impairing insulin sensitivity, counterbalances the deleterious cardiovascular and renal effects of aldosterone, and emerges as an alternative to improve blockade of the renin-angiotensin-aldosterone system, which potentially could contribute to reduce the burden of CVD and CKD.
C1 [Sowers, James R.] Univ Missouri, Dept Internal Med, Endocrinol & Diabet Div, MU Diabet & Cardiovasc Ctr, Columbia, MO 65212 USA.
C3 University of Missouri System; University of Missouri Columbia
RP Sowers, JR (corresponding author), Univ Missouri, Dept Internal Med, Endocrinol & Diabet Div, MU Diabet & Cardiovasc Ctr, D109 HSC Diabet Ctr,1 Hosp Dr, Columbia, MO 65212 USA.
EM sowersj@health.missouri.edu
FU Novartis; Merck Co.; Forest
FX Dr. Sowers has received support from Novartis, Merck & Co., and Forest.
   No other potential conflicts of interest relevant to this article were
   reported.
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NR 35
TC 9
Z9 11
U1 0
U2 3
PU CURRENT MEDICINE GROUP
PI PHILADELPHIA
PA 400 MARKET STREET, STE 700, PHILADELPHIA, PA 19106 USA
SN 1534-4827
EI 1539-0829
J9 CURR DIABETES REP
JI Curr. Diabetes Rep.
PD JUN
PY 2008
VL 8
IS 3
BP 203
EP 207
DI 10.1007/s11892-008-0035-9
PG 5
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 375FV
UT WOS:000261100400006
PM 18625117
DA 2025-06-11
ER

PT J
AU Chung, CC
   Kao, YH
   Chen, YJ
   Chen, YJ
AF Chung, Cheng-Chih
   Kao, Yu-Hsun
   Chen, Yu-Ju
   Chen, Yi-Jen
TI Androgen modulates cardiac fibrosis contributing to gender differences
   on heart failure
SO AGING MALE
LA English
DT Review
DE Androgen; fibroblasts; fibrosis; heart failure; testosterone;
   transforming growth factor-beta
ID ACUTE MYOCARDIAL-INFARCTION; GROWTH-FACTOR-BETA; COLLAGEN TYPE-I;
   SPONTANEOUSLY HYPERTENSIVE-RATS; ANGIOTENSIN-II; TESTOSTERONE
   UNDECANOATE; OXIDATIVE STRESS; TRANSFORMING GROWTH-FACTOR-BETA-1;
   METABOLIC SYNDROME; PRESSURE-OVERLOAD
AB Chronic heart failure (HF) is a major health problem throughout the world. Gender has significant effects on the pathophysiology of HF. Low levels of free testosterone are independently associated with increased chronic HF symptoms and mortality. Cardiac fibrosis plays a pivotal role in structural remodeling in HF. Transforming growth factor (TGF)-beta, angiotensin II and oxidative stress contribute to the activity/extent of cardiac fibrosis. Androgen deficiency can up-regulate TGF-beta expression under angiotensin II stimulation in vivo. In this review, we summarized the potential mechanisms accounting for the effects of androgen on cardiac fibrosis through regulating fibrocytes activity under TGF, which can explain wound healing and cardiac fibrosis in male with acute myocardial injury and chronic HF.
C1 [Chung, Cheng-Chih; Kao, Yu-Hsun; Chen, Yi-Jen] Taipei Med Univ, Grad Inst Clin Med, Coll Med, Taipei 11031, Taiwan.
   [Chung, Cheng-Chih; Chen, Yi-Jen] Taipei Med Univ, Wan Fang Hosp, Dept Internal Med, Div Cardiovasc Med, Taipei 11031, Taiwan.
   [Chen, Yu-Ju] Acad Sinica, Inst Chem, Taipei, Taiwan.
C3 Taipei Medical University; Taipei Medical University; Taipei Municipal
   WanFang Hospital; Academia Sinica - Taiwan
RP Chen, YJ (corresponding author), Taipei Med Univ, Grad Inst Clin Med, 250 Wu Hsing St, Taipei 11031, Taiwan.
EM a9900112@ms15.hinet.net
RI Chen, Yu-Ju/E-9481-2015
OI Chen, Yu-Ju/0000-0002-3178-6697
FU Taipei Medical University-Wan Fang Hospital [100swf05]
FX This study was supported by a grant from Taipei Medical University-Wan
   Fang Hospital Grant no. 100swf05.
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NR 95
TC 12
Z9 12
U1 0
U2 12
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 1368-5538
EI 1473-0790
J9 AGING MALE
JI Aging Male
PD MAR
PY 2013
VL 16
IS 1
BP 22
EP 27
DI 10.3109/13685538.2012.754008
PG 6
WC Endocrinology & Metabolism; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Urology & Nephrology
GA 105SQ
UT WOS:000316093200004
PM 23356882
OA Bronze
DA 2025-06-11
ER

PT J
AU Saedi, S
   Tan, Y
   Watson, SE
   Sparks, JD
   Wintergerst, KA
   Cai, L
AF Saedi, Saman
   Tan, Yi
   Watson, Sara E.
   Sparks, Joshua D.
   Wintergerst, Kupper A.
   Cai, Lu
TI Oxidative stress and pediatric diabetic cardiovascular complications:
   emerging research and clinical applications
SO AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
LA English
DT Review
DE cardiovascular complications; diabetic cardiomyopathy; oxidative stress;
   pediatric diabetes; therapeutic strategies
ID LONG-TERM COMPLICATIONS; INTIMA-MEDIA THICKNESS; INSULIN-RESISTANCE;
   RISK-FACTORS; ENDOTHELIAL DYSFUNCTION; OBESE CHILDREN; CARDIOMETABOLIC
   RISK; CHILDHOOD OBESITY; PHYSICAL-ACTIVITY; LIFETIME RISK
AB The prevalence and incidence of diabetes in pediatrics have dramatically increased over the last three decades. Comparatively, pediatric diabetes has faster pancreatic beta-cells decline and early progression to complications compared with adult diabetes. Therefore, diabetic complications are a major concern in children and adolescents with diabetes. Diabetes has detrimental effects on the macro- and microvascular systems, resulting in cardiovascular diseases, leading causes of morbidity and mortality in youth with diabetes. Oxidative stress plays a critical role in developing cardiovascular complications in the context of pediatric diabetes. In pediatric patients with diabetes, several factors can contribute to the development of excess reactive oxygen species and oxidative stress, including nutritional deficiencies, puberty, environmental exposures, and metabolic disorders such as obesity and high blood pressure. The present study aims to raise awareness of diabetic cardiovascular complications in children and adolescents with diabetes and the role of oxidative stress and their molecular mechanisms in the pathogenesis of cardiovascular complications. In addition, some novel therapeutic strategies for the treatment and prevention of diabetic cardiovascular complications in the pediatric populations are highlighted. In summary, children and adolescents with diabetes no matter type 1 diabetes (T1D) or type 1 diabetes (T2D), have many features similar to those in adults with same kinds of diabetes, but also have many their own features distinct from adults. By developing targeted therapies and preventive measures, healthcare providers can better address the rising incidence of diabetes-related complications in children and adolescents.
C1 [Saedi, Saman] Shiraz Univ, Coll Agr, Dept Anim Sci, Shiraz, Iran.
   [Tan, Yi; Watson, Sara E.; Wintergerst, Kupper A.; Cai, Lu] Univ Louisville Sch Med, Pediat Res Inst, Dept Pediat, Louisville, KY 40202 USA.
   [Tan, Yi; Watson, Sara E.; Wintergerst, Kupper A.; Cai, Lu] Norton Childrens Hosp, Wendy Novak Diabet Inst, Louisville, KY 40202 USA.
   [Tan, Yi; Cai, Lu] Univ Louisville Sch Med, Dept Pharmacol & Toxicol, Louisville, KY 40202 USA.
   [Watson, Sara E.; Wintergerst, Kupper A.] Univ Louisville Sch Med, Dept Pediat, Norton Childrens Endocrinol, Louisville, KY USA.
   [Sparks, Joshua D.] Univ Louisville Sch Med, Dept Pediat, Div Pediat Cardiol, Louisville, KY USA.
   [Wintergerst, Kupper A.; Cai, Lu] Univ Louisville Sch Med, Ctr Integrat Environm Hlth Sci, Louisville, KY 40202 USA.
   [Cai, Lu] Univ Louisville Sch Med, Dept Radiat Oncol, Louisville, KY 40202 USA.
C3 Shiraz University; University of Louisville; University of Louisville;
   University of Louisville; University of Louisville; University of
   Louisville; University of Louisville
RP Cai, L (corresponding author), Univ Louisville Sch Med, Pediat Res Inst, Dept Pediat, Louisville, KY 40202 USA.; Cai, L (corresponding author), Norton Childrens Hosp, Wendy Novak Diabet Inst, Louisville, KY 40202 USA.; Cai, L (corresponding author), Univ Louisville Sch Med, Dept Pharmacol & Toxicol, Louisville, KY 40202 USA.; Cai, L (corresponding author), Univ Louisville Sch Med, Ctr Integrat Environm Hlth Sci, Louisville, KY 40202 USA.; Cai, L (corresponding author), Univ Louisville Sch Med, Dept Radiat Oncol, Louisville, KY 40202 USA.
EM lu.cai@louisville.edu
RI Sparks, Joshua/HOA-8707-2023
FU National Institute of Environmental Health Sciences Grant for University
   of Louisville Center for Integrative Environmental Health Sciences (UofL
   CIEHS) [P30 ES030283]; National Heart, Lung, and Blood Institute [R01
   HL125877, HL160927, HL174922]; Jewish Heritage Fund for Excellence
   Research Enhancement Grant Program at the University of Louisville
   School of Medicine
FX This work was supported in part by funds from the National Institute of
   Environmental Health Sciences Grant P30 ES030283(to K.A.W. and L.C.) for
   University of Louisville Center for Integrative Environmental Health
   Sciences (UofL CIEHS), the National Heart, Lung, and Blood Institute
   Grants R01 HL125877,HL160927, and HL174922 (to Y.T. and L.C.), and the
   Jewish Heritage Fund for Excellence Research Enhancement Grant Program
   at the University of Louisville School of Medicine (to Y.T.).
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NR 204
TC 0
Z9 0
U1 1
U2 1
PU AMER PHYSIOLOGICAL SOC
PI Rockville
PA 6120 Executive Blvd, Suite 600, Rockville, MD, UNITED STATES
SN 0363-6135
EI 1522-1539
J9 AM J PHYSIOL-HEART C
JI Am. J. Physiol.-Heart Circul. Physiol.
PD APR 1
PY 2025
VL 328
IS 4
BP H945
EP H962
DI 10.1152/ajpheart.00673.2024
PG 18
WC Cardiac & Cardiovascular Systems; Physiology; Peripheral Vascular
   Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Physiology
GA 2NV6X
UT WOS:001487087500001
PM 40019178
DA 2025-06-11
ER

PT J
AU Lee, HS
   Park, JC
   Chung, I
   Liu, JX
   Lee, SS
   Han, K
AF Lee, Hong Seok
   Park, Jimin Clara
   Chung, Inkwan
   Liu, Junxiu
   Lee, Seong-Su
   Han, Kyungdo
TI Sustained Low Income, Income Changes, and Risk of All-Cause Mortality in
   Individuals With Type 2 Diabetes: A Nationwide Population-Based Cohort
   Study
SO DIABETES CARE
LA English
DT Article
ID SOCIOECONOMIC-STATUS; CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME;
   BLOOD-VISCOSITY; MENTAL-HEALTH; ASSOCIATION; MELLITUS; STRESS; ADULTS;
   DETERMINANTS
AB OBJECTIVE
   There is limited evidence on the association of sustained low-income status, income changes, and all-cause mortality risk in individuals with type 2 diabetes (T2D).
   RESEARCH DESIGN AND METHODS
   Using the Korean Health Insurance Service database, we studied 1,923,854 adults with T2D (aged >= 30 years) without cardiovascular disease and cancer, who were enrolled from 2009 through 2012 and followed to the end of 2020 (median 10.8 years of follow-up). We defined income levels based on the amount of health insurance premiums and categorized them into quartiles, the first being the low-income group, and assessed the income status annually in the preceding 5 years. Cox proportional hazards models were used to quantify the association of low-income status and income changes with mortality, with adjustment for sociodemographic factors, comorbidities, and diabetes duration and treatment.
   RESULTS
   Participants who consecutively had low income showed a higher risk of mortality (hazard ratio [HR] 1.19; 95% CI 1.16-1.22), compared with those who had never been in the low-income group. This association was much stronger for consecutive recipients of Medical Aid, reflecting very-low-income status (HR 2.26; 95% CI 2.16-2.36), compared with those who had never been Medical Aid beneficiaries. Sustained low- and very-low-income status was associated with increased risk of mortality, specifically for younger adults (aged <40 years) and males. Those who experienced declines in income between the first (preceding 5 years) and the last (baseline) time points had an increased risk of mortality, regardless of baseline income status.
   CONCLUSIONS
   Among Korean adults with T2D, sustained low- income status and declines in income were associated with increased risk of mortality.
C1 [Lee, Hong Seok] Univ Arizona, Dept Med, Tucson, AZ USA.
   [Park, Jimin Clara] Episcopal Coll Sch, Little Rock, AR USA.
   [Chung, Inkwan] Soongsil Univ, Dept Informat Sociol, Seoul, South Korea.
   [Liu, Junxiu] Icahn Sch Med Mt Sinai, Dept Populat Hlth Sci & Policy, New York, NY 10029 USA.
   [Lee, Seong-Su] Catholic Univ Korea, Div Endocrinol & Metab, Bucheon St Marys Hosp, Dept Internal Med,Coll Med, Seoul, South Korea.
   [Han, Kyungdo] Soongsil Univ, Dept Stat & Actuarial Sci, Seoul, South Korea.
C3 University of Arizona; Soongsil University; Icahn School of Medicine at
   Mount Sinai; Catholic University of Korea; Soongsil University
RP Lee, SS (corresponding author), Catholic Univ Korea, Div Endocrinol & Metab, Bucheon St Marys Hosp, Dept Internal Med,Coll Med, Seoul, South Korea.; Han, K (corresponding author), Soongsil Univ, Dept Stat & Actuarial Sci, Seoul, South Korea.
EM mddaniel@catholic.ac.kr; hkd917@naver.com
FU National Research Foundation of Korea - Korea government (Ministry of
   Science and ICT) [2019R1I1A1A01061188]
FX This work was supported by the National Research Foundation of Korea
   grant funded by the Korea government (Ministry of Science and ICT)
   (2019R1I1A1A01061188).
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NR 47
TC 7
Z9 7
U1 1
U2 10
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0149-5992
EI 1935-5548
J9 DIABETES CARE
JI Diabetes Care
PD JAN
PY 2023
VL 46
IS 1
BP 92
EP 100
DI 10.2337/dc21-2305
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 7K3RJ
UT WOS:000905203400020
PM 36367896
OA Green Submitted, Bronze
DA 2025-06-11
ER

EF﻿FN Clarivate Analytics Web of Science
VR 1.0
PT J
AU Fan, JH
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AF Fan, Jihuan
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   Cheng, Yanhua
   Lei, Jie
TI Correlation Between Metabolic Syndrome and Hyperuricemia: A Systematic
   Review and Meta-analysis
SO AMERICAN JOURNAL OF HYPERTENSION
LA English
DT Review; Early Access
DE blood pressure; hypertension; hyperuricemia; meta-analysis; metabolic
   syndrome; systematic review
ID SERUM URIC-ACID; CARDIOVASCULAR-DISEASE; OXIDATIVE STRESS; LONGITUDINAL
   ASSOCIATIONS; INDEPENDENT PREDICTOR; CHINESE ADULTS; RISK; PREVALENCE;
   HEALTH; POPULATION
AB BACKGROUND The main goal of this study was to conduct a meta-analysis and systematic review to examine the correlation between metabolic syndrome (MetS) and hyperuricemia. METHODS All studies available in PubMed, Cochrane Library, Embase, and Web of Science were obtained within the retrieval timeframe ending on 9 December 2023. Utilizing the Agency for Healthcare Research and Quality (AHRQ) and the Newcastle-Ottawa Scale (NOS), the included studies underwent quality appraisal, and Stata v14 software was employed for the subsequent data analysis. RESULTS A total of 40 studies, covering 214,091 patients, were selected based on specified inclusion and exclusion criteria. The analysis revealed a substantial association between MetS and hyperuricemia (odds ratio (OR) = 2.25, 95% confidence interval (CI) 1.19-4.26, P < 0.001). The metabolically abnormal overweight/obese group (MUHOWO) exhibited a heightened risk of hyperuricemia (OR = 3.54, 95% CI 2.66-4.71, P = 0.002). Additionally, hyperuricemia increased the likelihood of developing MetS (OR = 2.13, 95% CI 1.63-2.79, P < 0.001). Stratified by gender, hyperuricemia elevated the risk of MetS in both men (OR = 1.92, 95% CI 1.43-2.58, P < 0.001) and women (OR = 2.13, 95% CI 1.62-2.8, P < 0.001). CONCLUSIONS This meta-analysis and systematic review robustly affirm a significant bidirectional association between MetS and hyperuricemia. The increased risk observed, especially in MUHOWO and across gender lines, underscores the clinical relevance. Addressing MetS emerges as crucial in preventing and managing hyperuricemia, and vice versa. These findings offer valuable insights, urging further research into underlying mechanisms for more targeted interventions and personalized treatments in clinical practice.
C1 [Fan, Jihuan] Jilin Prov FAW Gen Hosp, Dept Teaching & Res, Changchun, Peoples R China.
   [Bian, Cuicui] Jilin Prov FAW Gen Hosp, Dept Hlth Checkup & Primary Care, Changchun, Peoples R China.
   [Wang, Jiapeng; Wang, Xinyue] Jilin Prov FAW Gen Hosp, Dept Org & Personnel, Changchun, Peoples R China.
   [Cheng, Yanhua] Jilin Prov FAW Gen Hosp, Dept Magnet Resonance, Changchun, Peoples R China.
   [Lei, Jie] Jilin Prov FAW Gen Hosp, Hosp Directors Offce, Changchun, Peoples R China.
RP Lei, J (corresponding author), Jilin Prov FAW Gen Hosp, Hosp Directors Offce, Changchun, Peoples R China.
EM lei_jie0306@163.com
RI Fan, Jihuan/GXM-5172-2022
FU Health Technology Capacity Improvement Project of Health Commission of
   Jilin Province [2022GL003]
FX This study was supported by Health Technology Capacity Improvement
   Project of Health Commission of Jilin Province (2022GL003).
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NR 91
TC 0
Z9 0
U1 2
U2 2
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0895-7061
EI 1941-7225
J9 AM J HYPERTENS
JI Am. J. Hypertens.
PD 2025 APR 25
PY 2025
DI 10.1093/ajh/hpaf031
EA APR 2025
PG 13
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 1UX4I
UT WOS:001474240000001
PM 40068943
DA 2025-06-11
ER

PT J
AU Lei, SS
   Peng, WH
   Wu, LL
   Yu, LY
   Wang, MD
   Li, QM
   Deng, Y
   Zhao, S
   Huang, PY
   Chen, BJ
AF Lei, Sisi
   Peng, Weihang
   Wu, Lulu
   Yu, Liyuan
   Wang, Meida
   Li, Qingmin
   Deng, Yi
   Zhao, Shuai
   Huang, Peiying
   Chen, Bojun
TI Chaihu Shugan powder restores fatty acid synthesis to alleviate insulin
   resistance in metabolic syndrome by regulating the LXRα/SREBP-1
   signaling pathway
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Article
DE Chaihu Shugan powder; metabolic syndrome; insulin resistance; LXR
   alpha/SREBP-1; fatty acid synthesis
ID LIVER; LIPOGENESIS; DIET
AB Background Metabolic syndrome (MS) is a significant risk factor for cardiovascular and cerebrovascular diseases, primarily driven by insulin resistance (IR). Although the herbal compound Chaihu Shugan powder (CSP) has demonstrated the potential to improve IR in animal models of MS, its mechanism of action remains incompletely understood. Therefore, this study aimed to investigate the biological pathways through which CSP exerts its therapeutic effects on IR in MS using both in vitro and in vivo methods.Methods The primary metabolites of CSP aqueous extract and CSP-containing serum were measured by LC-MS/MS. A mouse model of MS-related IR was induced by a high-fat, high-fructose diet combined with chronic immobilization stress. The CSP's therapeutic potential was evaluated through glucose and insulin tolerance tests and hepatic insulin signaling molecules (p-IRS-1, IRS-1, p-Akt, and Akt). The expression of lipid metabolism-related factors (FFA, DAG, LXR alpha, SREBP-1, FASN, and ACC) in the liver was also measured. Hepatocyte IR was modeled using high-glucose and high-insulin conditions, and CSP impact was evaluated using 2-NBDG uptake and insulin signaling molecule expression. The specific mechanism of CSP was explored using the LXR alpha agonist T0901317.Results The MS-related IR model exhibited a decreased p-Akt/Akt ratio and increased fasting glucose, insulin, homeostatic model assessment of IR, and hepatic lipid metabolism factors. Treatment with CSP mitigated these effects. In the hepatocyte IR model, CSP-containing serum improved glucose uptake and modulated the expression of insulin signaling and lipid metabolism factors. Furthermore, T0901317 reversed the beneficial effects of CSP, indicating the role of LXR alpha in CSP's therapeutic action.Conclusion The CSP ameliorated IR in MS by restoring fatty acid metabolism through the regulation of the LXR alpha/SREBP-1 signaling pathway.
C1 [Lei, Sisi; Peng, Weihang; Wu, Lulu; Yu, Liyuan; Wang, Meida; Chen, Bojun] Guangzhou Univ Chinese Med, Clin Med Sch 2, Guangzhou, Peoples R China.
   [Lei, Sisi] Peoples Hosp Guangxi Zhuang Autonomous Reg, Dept Tradit Chinese Med, Nanning, Peoples R China.
   [Li, Qingmin] First Peoples Hosp Chenzhou, Dept Tradit Chinese Med, Chenzhou, Peoples R China.
   [Deng, Yi; Zhao, Shuai; Huang, Peiying; Chen, Bojun] Guangdong Prov Hosp Tradit Chinese Med, Emergency Dept, Guangzhou, Peoples R China.
   [Chen, Bojun] Clin Res Team Prevent & Treatment Cardiac Emergenc, Guangdong Prov Key Lab Res Emergency Tradit Chines, Guangzhou, Peoples R China.
C3 Guangzhou University of Chinese Medicine; Guangzhou University of
   Chinese Medicine
RP Chen, BJ (corresponding author), Guangzhou Univ Chinese Med, Clin Med Sch 2, Guangzhou, Peoples R China.; Li, QM (corresponding author), First Peoples Hosp Chenzhou, Dept Tradit Chinese Med, Chenzhou, Peoples R China.; Huang, PY; Chen, BJ (corresponding author), Guangdong Prov Hosp Tradit Chinese Med, Emergency Dept, Guangzhou, Peoples R China.; Chen, BJ (corresponding author), Clin Res Team Prevent & Treatment Cardiac Emergenc, Guangdong Prov Key Lab Res Emergency Tradit Chines, Guangzhou, Peoples R China.
EM 277157546@qq.com; 20212110136@stu.gzucm.edu.cn; 719523476@qq.com
RI lei, sisi/JTU-2808-2023
FU National Natural Science Foundation of China [82074342]
FX The author(s) declare that financial support was received for the
   research, authorship, and/or publication of this article. This work was
   financially supported by grants from the National Natural Science
   Foundation of China(No. 82074342).
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NR 31
TC 1
Z9 1
U1 1
U2 1
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD NOV 5
PY 2024
VL 15
AR 1442279
DI 10.3389/fphar.2024.1442279
PG 13
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA M3T4V
UT WOS:001356803600001
PM 39564113
OA gold
DA 2025-06-11
ER

PT J
AU Podeanu, MA
   Turcu-Stiolica, A
   Subtirelu, MS
   Stepan, MD
   Ionele, CM
   Gheonea, DI
   Vintilescu, BS
   Sandu, RE
AF Podeanu, Mihaela-Andreea
   Turcu-Stiolica, Adina
   Subtirelu, Mihaela Simona
   Stepan, Mioara Desdemona
   Ionele, Claudiu-Marinel
   Gheonea, Dan-Ionut
   Vintilescu, Bianca Stefanita
   Sandu, Raluca Elena
TI C-Reactive Protein as a Marker of Inflammation in Children and
   Adolescents with Metabolic Syndrome: A Systematic Review and
   Meta-Analysis
SO BIOMEDICINES
LA English
DT Review
DE metabolic syndrome; C-reactive protein; inflammation; children;
   adolescents
ID CARDIOVASCULAR RISK; OXIDATIVE STRESS; OBESE CHILDREN; LIFE-STYLE;
   ASSOCIATION; SERUM; POPULATION; PREVALENCE; OVERWEIGHT; ADIPOSITY
AB Metabolic syndrome (MetS) in the pediatric population has been reported in many studies to be associated with an inflammatory response. However, to our knowledge, there is no definitive conclusion in the form of a meta-analysis. The issue we aimed to address is whether C-reactive protein (CRP) is a trustworthy marker in detecting inflammation in children and adolescents with MetS. We systematically searched PubMed, MEDLINE, Cochrane Central Register of Controlled Trials, the ISI Web of Science, and SCOPUS until 31 June 2023 for studies involving children and adolescents with MetS where hsCRP or CRP were measured. After the screening process, we identified 24 full-text articles that compared 930 patients with MetS with either healthy (n = 3782) or obese (n = 1658) controls. The risk of bias in the included studies was assessed using the Begg's rank correlation test and Egger's regression test. Statistical analysis was carried out based on pooled mean differences (MDs) and an associated 95% CI. Data analysis showed that MetS is associated with higher levels of CRP than those in healthy controls (MD = 1.28, 95% CI: (0.49-2.08), p = 0.002) in obese patients (MD = 0.88, 95% CI: (0.38-1.39), p = 0.0006). However, conventional methods of CRP analysis were found to be more accurate in differentiating between children and adolescents with obesity and those with MetS, compared with hsCRP (MD = 0.60, 95% CI: (-0.08-1.28), p = 0.08). No risk of bias was assessed. In conclusion, CRP is a reliable inflammatory marker for differentiating pediatric patients with MetS from healthy ones. On the other hand, it did not prove to be very accurate in distinguishing between patients who had MetS and those who were obese. There should be more research performed in this field.
C1 [Podeanu, Mihaela-Andreea] Univ Med & Pharm Craiova, Doctoral Sch, Craiova 200349, Romania.
   [Turcu-Stiolica, Adina; Subtirelu, Mihaela Simona] Univ Med & Pharm Craiova, Dept Pharmacoecon, Craiova 200349, Romania.
   [Stepan, Mioara Desdemona; Vintilescu, Bianca Stefanita] Univ Med & Pharm Craiova, Dept Infant Care Pediat & Neonatol, Craiova 200349, Romania.
   [Ionele, Claudiu-Marinel; Gheonea, Dan-Ionut] Univ Med & Pharm Craiova, Dept Gastroenterol, Craiova 200349, Romania.
   [Sandu, Raluca Elena] Univ Med & Pharm Craiova, Dept Biochem, Craiova 200349, Romania.
C3 University of Medicine & Pharmacy of Craiova; University of Medicine &
   Pharmacy of Craiova; University of Medicine & Pharmacy of Craiova;
   University of Medicine & Pharmacy of Craiova; University of Medicine &
   Pharmacy of Craiova
RP Turcu-Stiolica, A (corresponding author), Univ Med & Pharm Craiova, Dept Pharmacoecon, Craiova 200349, Romania.
EM podeanu.andreea11@gmail.com; adina.turcu@umfcv.ro;
   mihaela.subtirelu@yahoo.com; desdemona.stepan@umfcv.ro;
   ioneleclaudiu@gmail.com; dan.gheonea@umfcv.ro;
   vintilescubianca92@gmail.com; raluca.sandu@umfcv.ro
RI STEPAN, DESDEMONA/GZH-1533-2022; Gheonea, Dan/C-3578-2012; Naidin,
   Mihaela/GWQ-8130-2022; Turcu-Stiolica, Adina/C-5968-2017
OI Naidin, Mihaela Simona/0000-0001-9173-2976; Turcu-Stiolica,
   Adina/0000-0003-1374-276X; STEPAN, DESDEMONA/0000-0002-4095-6846;
   Podeanu, Mihaela-Andreea/0009-0002-9259-8806; Sandu, Raluca
   Elena/0009-0007-8707-9768; Ionele, Claudiu Marinel/0000-0001-5675-1741;
   Vintilescu, Stefanita Bianca/0000-0002-7801-5646
FU University of Medicine and Pharmacy of Craiova, Romania
FX No Statement Available
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NR 77
TC 19
Z9 20
U1 3
U2 13
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2227-9059
J9 BIOMEDICINES
JI Biomedicines
PD NOV
PY 2023
VL 11
IS 11
AR 2961
DI 10.3390/biomedicines11112961
PG 19
WC Biochemistry & Molecular Biology; Medicine, Research & Experimental;
   Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Research & Experimental Medicine;
   Pharmacology & Pharmacy
GA AJ5B4
UT WOS:001118101600001
PM 38001962
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Cao, TR
   Tong, C
   Halengbieke, A
   Ni, XT
   Tang, JM
   Zheng, DQ
   Guo, XH
   Yang, XH
AF Cao, Tengrui
   Tong, Chao
   Halengbieke, Aheyeerke
   Ni, Xuetong
   Tang, Jianmin
   Zheng, Deqiang
   Guo, Xiuhua
   Yang, Xinghua
TI Serum uric acid to creatinine ratio and metabolic syndrome in
   middle-aged and elderly population: Based on the 2015 CHARLS
SO NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
LA English
DT Article
DE Serum uric acid to creatinine ratio; Metabolic syndrome; Middle-aged and
   elderly population; CHARLS
ID C-REACTIVE PROTEIN; 3RD NATIONAL-HEALTH; UNITED-STATES; RISK;
   PREVALENCE; PREDICTOR; METAANALYSIS; ASSOCIATION; MORTALITY; STRESS
AB Background and aims: Serum uric acid to creatinine ratio (SUA/Cr) may be associated with metabolic syndrome (MS). Here, we investigated the correlation between SUA/Cr and MS in Chinese residents aged >= 45 years.
   Methods and results: Data were obtained from the 2015 China Health and Retirement Longitudinal Study (CHARLS) database. MS was diagnosed using the Chinese Diabetes Society 2017 criteria. We grouped the population according to SUA/Cr quartiles and compared the index differences between groups. We used spearman correlation analysis and binary logistic regression. The possible dose-response association of SUA/Cr with MS were analyzed using restricted cubic spline model. Of 12,946 included participants, 3370 (26.0%) had MS, and 1900 (56.4%) were female. After adjusting for multiple confounders, binary logistic regression analysis showed that compared with Quartile 1, the odds ratio (95% confidence interval) of the MS risk was 1.29 (1.09e1.52), 1.47 (1.25e1.74), and 1.80 ( 1.53e2.12) in Quartiles 2, 3, and 4, respectively. The restricted cubic spline model indicated a significant nonlinear dose-response association (Poverall < 0.001, Pnon- linearity Z 0.029) between SUA/Cr and strength of MS prevalence association; MS risk began increasing when SUA/Cr > 6.22.
   Conclusions: A significant positive correlation existed between SUA/Cr and MS risk in Chinese individuals aged >= 45 years, which may be a new predictive marker for MS risk.
   (c) 2023 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.
C1 [Cao, Tengrui; Tong, Chao; Halengbieke, Aheyeerke; Ni, Xuetong; Tang, Jianmin; Zheng, Deqiang; Guo, Xiuhua; Yang, Xinghua] Capital Med Univ, Sch Publ Hlth, 10 Xitoutiao, Beijing 100069, Peoples R China.
   [Cao, Tengrui; Tong, Chao; Halengbieke, Aheyeerke; Ni, Xuetong; Tang, Jianmin; Zheng, Deqiang; Guo, Xiuhua; Yang, Xinghua] Beijing Municipal Key Lab Clin Epidemiol, 10 Xitoutiao, Beijing 100069, Peoples R China.
C3 Capital Medical University
RP Yang, XH (corresponding author), Capital Med Univ, Sch Publ Hlth, 10 Xitoutiao, Beijing 100069, Peoples R China.
EM caotengrui0417@163.com; xdftongchao@126.com; ahyerkie123@163.com;
   nixuetong123@163.com; tangjianmin127@163.com; deqiangzheng@163.com;
   guoxiuh@ccmu.edu.cn; xinghuayang@ccmu.edu.cn
RI JIANMIN, TANG/JBS-6054-2023
FU Beijing Natural Science Foundation [2020YFC2003404]; National Key Ramp;D
   Program of China;  [7202010]
FX This study was supported by the Beijing Natural Science Foundation
   [grant numbers 7202010] , and the National Key R & D Program of China
   [grant numbers 2020YFC2003404] .
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NR 51
TC 7
Z9 7
U1 9
U2 33
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 0939-4753
EI 1590-3729
J9 NUTR METAB CARDIOVAS
JI Nutr. Metab. Carbiovasc. Dis.
PD JUL
PY 2023
VL 33
IS 7
BP 1339
EP 1348
DI 10.1016/j.numecd.2023.05.004
EA JUN 2023
PG 10
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism; Nutrition
   & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism;
   Nutrition & Dietetics
GA Q5LB1
UT WOS:001057924300001
PM 37248143
DA 2025-06-11
ER

PT J
AU Piazzini, V
   Micheli, L
   Luceri, C
   D'Ambrosio, M
   Cinci, L
   Ghelardini, C
   Bilia, AR
   Mannelli, LD
   Bergonzi, MC
AF Piazzini, Vieri
   Micheli, Laura
   Luceri, Cristina
   D'Ambrosio, Mario
   Cinci, Lorenzo
   Ghelardini, Carla
   Bilia, Anna Rita
   Mannelli, Lorenzo Di Cesare
   Bergonzi, Maria Camilla
TI Nanostructured lipid carriers for oral delivery of silymarin: Improving
   its absorption and in vivo efficacy in type 2 diabetes and
   metabolic syndrome model
SO INTERNATIONAL JOURNAL OF PHARMACEUTICS
LA English
DT Article
DE Silymarin; Nanostructured lipid carriers; PAMPA; Caco-2 cell line;
   Diabetes; Metabolic syndrome
ID MARIANUM L. GAERTN.; HIGH-FAT DIET; OXIDATIVE STRESS; DRUG-DELIVERY;
   NANOPARTICLES; RAT; PERMEABILITY; VITRO; PERMEATION; PREDICTION
AB Silymarin (SLM) is a mixture of flavonolignans extracted from the fruit of Silybum marianum L. Gaertn. which has been used for decades as a hepatoprotector. Silymarin has recently been proposed to be beneficial in type 2 diabetic patients. Constituents of SLM are poorly water-soluble and low permeable compounds, with consequently limited oral bioavailability. This study aimed to investigate the possibility of delivery of SLM via nanostructured lipid carriers (NLCs) to overcome these issues and for preparation of an oral dosage form. NLCs were prepared through an emulsion/evaporation/solidifying method. Cetyl palmitate:Lauroglycol 90 was selected as the lipid mixture and Brij S20 as surfactant. NLCs were chemically and physically characterized. Encapsulation efficiency was more than 92%. The storage stability of the NLC suspension was also investigated and the freeze-drying process was taken into consideration. After assessing the stability of the formulation in a simulated gastrointestinal environment, the release of SLM was monitored in different pH conditions. In vitro experiments with artificial membranes (PAMPA) and Caco-2 cells revealed that the NLCs enhanced the permeation of SLM. Active processes are involved in the internalization of NLCs, as evidenced by cellular uptake studies. After preliminary toxicological studies, the formulation was studied in vivo in a streptozotocin (STZ)-induced diabetic mouse model in the presence of metabolic syndrome. The formulation was also compared to an NLC containing stearic acid:Capryol 90, to evaluate the effect of the lipid matrix on the in vivo performance of nanocarriers. Finally, hepatic histopathological analyses were also conducted. Both SLM-loaded NLCs exhibited in vivo a significant down-regulation of blood glucose and triglyceride levels better than free SLM, with a liver-protective effect. Furthermore, both formulations showed a significant anti-hyperalgesic effect on STZ-induced neuropathy.
C1 [Piazzini, Vieri; Bergonzi, Maria Camilla] Univ Florence, Dept Chem, Via U Schiff 6, I-50019 Florence, Italy.
   [Micheli, Laura; Luceri, Cristina; D'Ambrosio, Mario; Cinci, Lorenzo; Ghelardini, Carla; Bilia, Anna Rita; Mannelli, Lorenzo Di Cesare] Univ Florence, Dept Neurosci Psychol Drug Res & Childrens Hlth, Sect Pharmacol & Toxicol, NEUROFARBA, Viale Pieraccini 6, I-50139 Florence, Italy.
C3 University of Florence; University of Florence
RP Bergonzi, MC (corresponding author), Univ Florence, Dept Chem, Via U Schiff 6, I-50019 Florence, Italy.
EM mc.bergonzi@unifi.it
RI Micheli, Laura/F-5712-2019; Bilia, Anna/AAL-2963-2020; Mannelli,
   Lorenzo/A-7165-2012; Luceri, Cristina/N-4926-2016; Piazzini,
   Vieri/L-2241-2016
OI Micheli, Laura/0000-0001-8834-5801; Bilia, Anna
   Rita/0000-0001-8772-1895; Luceri, Cristina/0000-0003-1232-8778;
   Piazzini, Vieri/0000-0002-3010-165X
FU Ente Cassa di Risparmio di Firenze [2016.0802]
FX This research was funded by Ente Cassa di Risparmio di Firenze 2016,
   grant number 2016.0802.
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NR 74
TC 26
Z9 29
U1 4
U2 21
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0378-5173
EI 1873-3476
J9 INT J PHARMACEUT
JI Int. J. Pharm.
PD DEC 15
PY 2019
VL 572
AR 118838
DI 10.1016/j.ijpharm.2019.118838
PG 12
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA JS4WU
UT WOS:000500308000080
PM 31715362
DA 2025-06-11
ER

PT J
AU Goldstein, BI
   Fagiolini, A
   Houck, P
   Kupfer, DJ
AF Goldstein, Benjamin I.
   Fagiolini, Andrea
   Houck, Patricia
   Kupfer, David J.
TI Cardiovascular disease and hypertension among adults with bipolar I
   disorder in the United States
SO BIPOLAR DISORDERS
LA English
DT Article
DE bipolar disorder; cardiovascular; cardiovascular disease; epidemiologic;
   hypertension
ID NATIONAL EPIDEMIOLOGIC SURVEY; RISK-FACTORS; MYOCARDIAL-INFARCTION;
   METABOLIC SYNDROME; MAJOR DEPRESSION; POPULATION; PREVALENCE;
   SCHIZOPHRENIA; ALCOHOL; MOOD
AB Objective:
   Despite ample evidence of excess cardiovascular mortality in bipolar disorder (BD), few studies have demonstrated increased prevalence of cardiovascular disease (CVD) and/or hypertension (HTN) in BD. We therefore examined this topic in a representative epidemiologic sample.
   Method:
   The 2001-2002 National Epidemiologic Survey on Alcohol and Related Conditions was used to determine whether prevalence of physician-diagnosed CVD and HTN is elevated among subjects with lifetime bipolar I disorder (BD-I), and whether CVD and HTN are prevalent at earlier ages among subjects with BD-I.
   Results:
   The age-, race-, and sex-adjusted prevalence of CVD was significantly greater among subjects with BD-I versus controls [odds ratio (OR) = 4.95, 95% confidence interval (CI): 4.27-5.75] and versus subjects with major depressive disorder [(MDD); OR =1.80, 95% CI: 1.52-2.14], as was the prevalence of HTN (OR = 2.38, 95% CI: 2.16-2.62 versus controls, OR = 1.44, 95% CI: 1.30-1.61 versus MDD; p < 0.0001 for all). Controlling additionally for marital status, education, income, obesity, smoking, anxiety disorders, and substance use disorders did not substantially alter these findings. The mean age of BD-I subjects with CVD and HTN was 14 and 13 years younger, respectively, than controls with CVD and HTN.
   Conclusions:
   Adults with BD-I are at increased risk of CVD and HTN, prevalent over a decade earlier than non-BD adults. Strategies are needed to prevent excessive and premature cardiovascular burden in BD-I.
C1 [Goldstein, Benjamin I.] Univ Toronto, Fac Med, Sunnybrook Hlth Sci Ctr, Dept Psychiat, Toronto, ON M4N 3M5, Canada.
   [Goldstein, Benjamin I.; Fagiolini, Andrea; Houck, Patricia; Kupfer, David J.] Univ Pittsburgh, Sch Med, Western Psychiat Inst & Clin, Pittsburgh, PA USA.
   [Fagiolini, Andrea] Univ Siena, Sch Med, Div Psychiat, Dept Neurosci, I-53100 Siena, Italy.
C3 University of Toronto; Sunnybrook Health Science Center; Sunnybrook
   Research Institute; Pennsylvania Commonwealth System of Higher Education
   (PCSHE); University of Pittsburgh; Western Psychiatric Institute &
   Clinic of UPMC; University of Siena
RP Goldstein, BI (corresponding author), Univ Toronto, Fac Med, Sunnybrook Hlth Sci Ctr, Dept Psychiat, 2079 Bayview Ave, Toronto, ON M4N 3M5, Canada.
EM benjamin.goldstein@sunnybrook.ca
RI Goldstein, Benjamin/ADR-2374-2022; FAGIOLINI, ANDREA/T-2772-2017
OI FAGIOLINI, ANDREA/0000-0001-5827-0853
FU National Institute of Mental Health [R25MH060473]; NESARC; National
   Institute on Alcohol Abuse and Alcoholism, Bethesda, MD, USA; National
   Institute on Drug Abuse, Bethesda, MD, USA
FX Supported in part by the National Institute of Mental Health R25MH060473
   (BIG). The NESARC is supported by the National Institute on Alcohol
   Abuse and Alcoholism, Bethesda, MD, USA, with supplemental support from
   the National Institute on Drug Abuse, Bethesda, MD, USA. The views and
   opinions expressed in this article are those of the authors and should
   not be construed to represent the views of the sponsoring organizations.
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NR 34
TC 205
Z9 229
U1 0
U2 11
PU WILEY-BLACKWELL PUBLISHING, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1398-5647
J9 BIPOLAR DISORD
JI Bipolar Disord.
PD SEP
PY 2009
VL 11
IS 6
BP 657
EP 662
DI 10.1111/j.1399-5618.2009.00735.x
PG 6
WC Clinical Neurology; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Psychiatry
GA 481ZE
UT WOS:000268851800008
PM 19689508
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Nevels, TL
   Burch, JB
   Wirth, MD
   Ginsberg, JP
   McLain, AC
   Andrew, ME
   Allison, P
   Fekedulegn, D
   Violanti, JM
AF Nevels, Torrance L.
   Burch, James B.
   Wirth, Michael D.
   Ginsberg, J. P.
   McLain, Alexander C.
   Andrew, Michael E.
   Allison, Penelope
   Fekedulegn, Desta
   Violanti, John M.
TI Shift Work Adaptation Among Police Officers: The BCOPS Study
SO CHRONOBIOLOGY INTERNATIONAL
LA English
DT Article
DE Police officers; shiftwork adaptation and maladaptation; metabolic and
   immune system biomarkers; sleep; stress
ID SLEEP QUALITY; TOLERANCE; INDEX; RISK
AB Few studies have examined shiftwork adaptation among police officers or potential differences in disease biomarkers among adapted and maladapted shiftworkers. This study characterized shiftwork adaptation among 430 police officers from the Buffalo Cardio-Metabolic Occupational Police Stress (BCOPS) study. Police officers working fixed night shifts with symptoms characteristic of adaptation and maladaptation were identified using latent class analysis (n = 242). Two approaches were applied, one with police-specific symptoms and another using more general symptoms as shiftwork adaptation indicators. Biomarkers of inflammation, heart rate variability, and cardiometabolic risk were then compared between shiftwork adaptation groups, and with officers working day shifts, after adjusting for confounding. When analyses included police-specific symptoms, maladapted shiftworkers (n = 73) had more self-reported stress, sleep disturbances, fatigue, and less social support than adapted shiftworkers (n = 169). Using more general symptoms, maladapted officers (n = 56) reported more stress and depression, and less social support than adapted officers (n = 186). In police-specific models, adjusted (least-squares) means (+/- standard error) of circulating interleukin-6 (IL-6) concentrations in maladapted officers (0.8 +/- 0.1 ln[pg/ml]) were modestly elevated relative to adapted shiftworkers (0.7 +/- 0.1 ln[pg/ml], p = .09) and relative to permanent day workers (0.5 +/- 0.1 ln[pg/ml], p <= 0.01), and leptin levels in maladapted officers (9.6 +/- 0.1 ln[pg/ml]) exceeded those in the adapted (9.4 +/- 0.1 ln[pg/ml], p <= 0.01) and day shift groups (9.4 +/- 0.1 ln[pg/ml], p = .03). In the general model, adjusted mean tumor necrosis factor-alpha (TNF-alpha) concentrations among maladapted officers (5.6 +/- 0.23 pg/ml) exceeded the adapted (4.8 +/- 0.2 pg/ml, p <= 0.01) and day workers (5.0 +/- 0.2 pg/ml, p = .04), and insulin among maladapted officers was higher (2.4 +/- 0.1 ln[uu/ml]) than the adapted group (1.8 +/- 0.1 ln[uu/ml], p = .03). No differences were observed for the other biomarkers. The results suggest that maladaptation among police officers working fixed night shifts may lead to increases in leptin, insulin, IL-6, and TNF-alpha; however, the cross-sectional design and possible residual confounding preclude interpretation of cause and effect. Prospective studies are planned to further characterize the relationship between shiftwork maladaptation and biomarkers of chronic disease risk in this police officer cohort.
C1 [Nevels, Torrance L.; Burch, James B.; Wirth, Michael D.; McLain, Alexander C.] Univ South Carolina, Arnold Sch Publ Hlth, Dept Epidemiol & Biostat, Columbia, SC 29208 USA.
   [Nevels, Torrance L.; Burch, James B.; Ginsberg, J. P.] WJB Dorn Dept Vet Affairs Med Ctr, Dorn Res Inst, Columbia, SC USA.
   [Nevels, Torrance L.] MEDCoE, Interserv Phys Assistant Program, Joint Base San Antonio, TX USA.
   [Ginsberg, J. P.] Univ South Carolina, Sch Med, Dept Pharmacol Physiol & Neurosci, Columbia, SC 29208 USA.
   [Andrew, Michael E.; Allison, Penelope; Fekedulegn, Desta] NIOSH, Bioanalyt Branch, Hlth Effects Lab Div, Ctr Dis Control & Prevent, Morgantown, WV USA.
   [Violanti, John M.] SUNY Buffalo, Sch Publ Hlth & Hlth Profess, Dept Epidemiol & Environm Hlth, Buffalo, NY USA.
C3 University of South Carolina System; University of South Carolina
   Columbia; University of South Carolina System; University of South
   Carolina Columbia; Centers for Disease Control & Prevention - USA;
   National Institute for Occupational Safety & Health (NIOSH); State
   University of New York (SUNY) System; University at Buffalo, SUNY
RP Nevels, TL (corresponding author), MEDCoE, Interserv Phys Assistant Program, 3630 Stanley Rd,Bldg 2841, San Antonio, TX 78234 USA.
EM crimsonpa2009@gmail.com
RI McLain, Alexander/AFD-8215-2022; Wirth, Michael/C-6330-2013
OI McLain, Alexander/0000-0002-5475-0670
FU National Institute of Justice [2019-R2-CX-0021]
FX This work was supported by the National Institute of Justice
   [2019-R2-CX-0021].
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NR 123
TC 9
Z9 11
U1 0
U2 12
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 0742-0528
EI 1525-6073
J9 CHRONOBIOL INT
JI Chronobiol. Int.
PD JUN 3
PY 2021
VL 38
IS 6
BP 907
EP 923
DI 10.1080/07420528.2021.1895824
EA MAR 2021
PG 17
WC Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Life Sciences & Biomedicine - Other Topics; Physiology
GA SF4SR
UT WOS:000635012000001
PM 33781135
OA Green Accepted, Green Submitted
DA 2025-06-11
ER

PT J
AU Lin, HYH
   Chen, IY
   Wang, TM
   Yen, CH
   Chen, YM
   Chen, YH
   Dai, DF
   Huang, JF
   Chiu, YW
   Yang, MY
AF Lin, Hugo Y. -H.
   Chen, I-Ya
   Wang, Tzu-Ming
   Yen, Chia-Hung
   Chen, Yumay
   Chen, Yen-Hua
   Dai, Dao-Fu
   Huang, Jee-Fu
   Chiu, Yi-Wen
   Yang, Ming-Yu
TI The Role of Mitochondrial AKT1 Signaling in Renal Tubular Injury of
   Metabolic Syndrome
SO KIDNEY INTERNATIONAL REPORTS
LA English
DT Article
DE AKT1 signaling; kidney disease; metabolic syndrome; mitochondrial
   dysfunction; renal tubular injury
ID CHRONIC KIDNEY-DISEASE; OXIDATIVE STRESS; OBESITY; PATHOPHYSIOLOGY;
   RESISTANCE; INSULIN; CELLS; RISK
AB Introduction: Metabolic syndrome (MetS) is increasingly recognized as a contributor to kidney disease, yet the underlying mechanisms remain poorly defined. Recent studies suggest a pivotal role for mitochondrial dysfunction in renal injury. We hypothesized that mitochondrial AKT1 signaling in renal tubules plays a critical role in MetS-related kidney injuries. Methods: MetS was induced in a 8-week-old C57BL/6 male mice using a high-fat diet (HFD) for 4 months compared with controls on a standard chow diet. Additional experiments were conducted in DB/DB diabetic mice and their controls (WT and DB/WT) to validate findings. Renal metabolic parameters, mitochondrial AKT1 signaling, and markers of kidney injury were assessed. Results: MetS mice exhibited significant weight gain, altered glucose handling, and decreased energy expenditure. Although kidney size and basic renal function (blood urea nitrogen [BUN], creatinine) were unchanged, markers of renal damage, including proteinuria (P = 0.0002) and KIM-1(P < 0.0001) were elevated. Histological analyses showed increased tubular injury (P < 0.0001) and glomerulosclerosis (P = 0.0004). Transmission electron microscopy revealed aberrant mitochondria (P < 0.001), with reduced cristae length (P = 0.012) and numbers (P < 0.001). Immunohistochemistry, immunofluorescence, and Western blot analysis confirmed increased phosphorylated AKT1 (pAKT1) in the mitochondria of renal tubules (P = 0.0474), findings corroborated in DB/DB mice. This translocation of pAKT1 into mitochondria correlated with decreased cell viability upon inhibition of heat shock protein 90, indicating a dependency on mitochondrial AKT1 for cell survival. Conclusion: These findings underscore the mechanistic link between mitochondrial AKT1 signaling and renal tubular injury in MetS. Targeting mitochondrial dysfunction may offer new avenues for preventing and treating kidney diseases in patients with MetS.
C1 [Lin, Hugo Y. -H.; Chiu, Yi-Wen] Kaohsiung Med Univ Hosp, Dept Internal Med, Div Nephrol, Kaohsiung, Taiwan.
   [Lin, Hugo Y. -H.] Kaohsiung Med Univ, Dept Med, Kaohsiung, Taiwan.
   [Lin, Hugo Y. -H.] Kaohsiung Med Univ, Grad Inst Med, Coll Med, Kaohsiung, Taiwan.
   [Chen, I-Ya; Yang, Ming-Yu] Chang Gung Univ, Grad Inst Clin Med Sci, Coll Med, 259,Wenhua 1st Rd, Taoyuan, Taiwan.
   [Wang, Tzu-Ming] China Med Univ Hosp, Dept Med Res, Taichung, Taiwan.
   [Yen, Chia-Hung] Kaohsiung Med Univ, Grad Inst Nat Prod, Coll Pharm, Kaohsiung, Taiwan.
   [Chen, Yumay] Univ Calif Irvine, Sch Med, Irvine, CA USA.
   [Chen, Yen-Hua] Natl Sun Yat sen Univ, Coll Med, Sch Med, Doctoral Program Clin & Expt Med,Inst Biomed Sci, Kaohsiung, Taiwan.
   [Dai, Dao-Fu] Johns Hopkins Univ, Sch Med, Dept Pathol, Baltimore, MD USA.
   [Huang, Jee-Fu] Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Internal Med, Div Cardiol, Kaohsiung, Taiwan.
   [Yang, Ming-Yu] Kaohsiung Chang Gung Mem Hosp, Dept Otolaryngol, Kaohsiung, Taiwan.
   [Yang, Ming-Yu] Chang Gung Univ, Coll Med, Kaohsiung, Taiwan.
   [Chiu, Yi-Wen] Kaohsiung Med Univ Hosp, Dept Surg, 100,Shih Chuan 1st Rd, Kaohsiung, Taiwan.
C3 Kaohsiung Medical University; Kaohsiung Medical University Hospital;
   Kaohsiung Medical University; Kaohsiung Medical University; Chang Gung
   University; China Medical University Taiwan; China Medical University
   Hospital - Taiwan; Kaohsiung Medical University; University of
   California System; University of California Irvine; National Sun Yat Sen
   University; Johns Hopkins University; Kaohsiung Medical University;
   Kaohsiung Medical University Hospital; Chang Gung Memorial Hospital;
   Chang Gung University; Kaohsiung Medical University; Kaohsiung Medical
   University Hospital
RP Yang, MY (corresponding author), Chang Gung Univ, Grad Inst Clin Med Sci, Coll Med, 259,Wenhua 1st Rd, Taoyuan, Taiwan.; Chiu, YW (corresponding author), Kaohsiung Med Univ Hosp, Dept Surg, 100,Shih Chuan 1st Rd, Kaohsiung, Taiwan.
EM k81069@kmu.edu.tw; yangmy@mail.cgu.edu.tw
RI Yen, Chia-Hung/AFL-8668-2022; Chiu, Yi-Wen/D-5041-2009; Dai,
   Dao-Fu/AAM-4396-2021
FU Ministry of Science and Technology [110-2314-B-037-068-MY3,
   113-2314-B-037-107-MY3]; Kaohsiung Medical University [NK113P22,
   NK114P_14, KMTTH-DK (A) 114001]; Chang Gung Memorial Hospital
   [CMRPD8J0011, CMRPD8J0012, CMRPD8J0013, CMRPD8P0011]
FX Funding Funding was provided by the Ministry of Science and Technology
   (110-2314-B-037-068-MY3, 113-2314-B-037-107-MY3) , Kaohsiung Medical
   University (NK113P22, NK114P_14, KMTTH-DK (A) 114001) , and Chang Gung
   Memorial Hospital (CMRPD8J0011, CMRPD8J0012, CMRPD8J0013, and
   CMRPD8P0011) . The findings and conclusions in this report are those of
   the authors and do not necessarily represent the official position of
   the fund-ing organizations.
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NR 48
TC 0
Z9 0
U1 1
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 2468-0249
J9 KIDNEY INT REP
JI Kidney Int. Rep.
PD MAR
PY 2025
VL 10
IS 3
BP 906
EP 920
DI 10.1016/j.ekir.2024.12.021
EA MAR 2025
PG 15
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA Z7M2U
UT WOS:001440695000001
PM 40225378
OA gold
DA 2025-06-11
ER

PT J
AU Wang, X
   Karvonen-Gutierrez, CA
   Herman, WH
   Mukherjee, B
   Park, SK
AF Wang, Xin
   Karvonen-Gutierrez, Carrie A.
   Herman, William H.
   Mukherjee, Bhramar
   Park, Sung Kyun
TI Metals and risk of incident metabolic syndrome in a prospective cohort
   of midlife women in the United States
SO ENVIRONMENTAL RESEARCH
LA English
DT Article
DE Metals; Arsenic; Cobalt; Zinc; Metabolic syndrome; Women
ID INORGANIC ARSENIC EXPOSURE; NATIONAL-HEALTH; BLOOD-PRESSURE;
   LIPID-PEROXIDATION; PHYSICAL-ACTIVITY; OXIDATIVE STRESS; HEAVY-METALS;
   POPULATION; CADMIUM; ZINC
AB Exposure to metals may contribute to the development of metabolic syndrome (MetS); however, evidence from midlife women who are at greater risk of cardiometabolic disease is limited. We assessed the associations of 15 urinary metal concentrations with incident MetS in a prospective cohort of midlife women in the United States. The study population included 947 White, Black, Chinese and Japanese women, aged 45-56 years, free of MetS at baseline (1999-2000), who participated in the Study of Women's Health Across the Nation Multi-Pollutant Study. Fifteen metals were detected in almost all participants urine samples using inductively coupled plasma mass spectrometry at the baseline. Incident MetS was identified annually through 2017 as having at least three of the following five components: high blood pressure, impaired fasting glucose, abdominal obesity, high triglycerides, and poor high-density lipoprotein cholesterol. We used the Cox proportional hazards models to investigate the associations between individual metals and MetS incidence. The adjusted hazard ratios (HR) (95% CI) for MetS in associations with each doubling of urinary metal concentration were 1.14 (1.08, 1.23) for arsenic, 1.14 (1.01, 1.29) for cobalt, and 1.20 (1.06, 1.37) for zinc. We further evaluated the associations between metal mixtures and MetS using the elastic net penalized Cox model and summarized the results into the environmental risk score (ERS). Arsenic, barium, cobalt, copper, nickel, antimony, thallium, and zinc had positive weights, and cadmium, cesium, mercury, molybdenum, lead, and tin had negative weights in the construction of the ERS. The adjusted HR of MetS comparing 75th vs. 25th percentiles of the ERS was 1.45 (1.13, 1.87). These findings support the view that arsenic, cobalt, zinc, as well as metal mixtures, might influence the risks of incident MetS in midlife women.
C1 [Wang, Xin; Karvonen-Gutierrez, Carrie A.; Herman, William H.; Park, Sung Kyun] Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI USA.
   [Herman, William H.] Univ Michigan, Dept Internal Med, Ann Arbor, MI USA.
   [Mukherjee, Bhramar] Univ Michigan, Sch Publ Hlth, Dept Biostat, Ann Arbor, MI USA.
   [Park, Sung Kyun] Univ Michigan, Sch Publ Hlth, Dept Environm Hlth Sci, Ann Arbor, MI USA.
C3 University of Michigan System; University of Michigan; University of
   Michigan System; University of Michigan; University of Michigan System;
   University of Michigan; University of Michigan System; University of
   Michigan
RP Park, SK (corresponding author), Univ Michigan, Dept Epidemiol, M5541 SPH 2,1415 Washington Hts, Ann Arbor, MI 48109 USA.
EM sungkyun@unich.edu
OI Wang, Xin/0000-0002-0851-6605; Park, Sung Kyun/0000-0001-9981-6250
FU National Institutes of Health (NIH), DHHS, through the National
   Institute on Aging (NIA); National Institute of Nursing Research (NINR);
   NIH Office of Research on Women's Health (ORWH) [U01NR004061,
   U01AG012505, U01AG012535, U01AG012531, U01AG012539, U01AG012546,
   U01AG012553, U01AG012554, U01AG012495, U19AG063720]; National Institute
   of Environmental Health Sciences (NIEHS) [R01-ES026578, R01-ES026964,
   P30-ES017885]; Center for Disease Control and Prevention (CDC)/National
   Institute for Occupational Safety and Health (NIOSH) [T42-OH008455];
   SWAN Repository [U01AG017719]; National Institute for Occupational
   Safety and Health [T42OH008455] Funding Source: NIH RePORTER; National
   Institute of Diabetes and Digestive and Kidney Diseases [P30DK092926]
   Funding Source: NIH RePORTER; National Institute of Environmental Health
   Sciences [P30ES017885, R01ES026964] Funding Source: NIH RePORTER;
   National Institute on Aging [R01AG062622] Funding Source: NIH RePORTER
FX The Study of Women's Health Across the Nation (SWAN) has grant support
   from the National Institutes of Health (NIH), DHHS, through the National
   Institute on Aging (NIA), the National Institute of Nursing Research
   (NINR) and the NIH Office of Research on Women's Health (ORWH) (Grants
   U01NR004061; U01AG012505, U01AG012535, U01AG012531, U01AG012539,
   U01AG012546, U01AG012553, U01AG012554, U01AG012495, and U19AG063720).
   The study was supported by the SWAN Repository (U01AG017719). This study
   was also supported by grants from the National Institute of
   Environmental Health Sciences (NIEHS) R01-ES026578, R01-ES026964 and
   P30-ES017885, and by the Center for Disease Control and Prevention
   (CDC)/National Institute for Occupational Safety and Health (NIOSH)
   grant T42-OH008455.
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NR 104
TC 37
Z9 38
U1 3
U2 28
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0013-9351
EI 1096-0953
J9 ENVIRON RES
JI Environ. Res.
PD JUL
PY 2022
VL 210
AR 112976
DI 10.1016/j.envres.2022.112976
EA FEB 2022
PG 11
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA ZX8MG
UT WOS:000772146500012
PM 35202625
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Paik, JK
   Park, M
   Shin, JE
   Jang, SY
   Shin, JY
AF Paik, Jean Kyung
   Park, Mira
   Shin, Ji Eun
   Jang, Suk-Yong
   Shin, Ji-Yeon
TI Dietary Protein to Carbohydrate Ratio and Incidence of Metabolic
   Syndrome in Korean Adults Based on a Long-Term Prospective
   Community-Based Cohort
SO NUTRIENTS
LA English
DT Article
DE protein; carbohydrate; ratio; metabolic syndrome
ID INSULIN-RESISTANCE; OXIDATIVE STRESS; LIPID-METABOLISM; CALORIC-INTAKE;
   RISK; DISEASE; WEIGHT; HEALTH; ENERGY; SEX
AB Interest in high protein diets has recently been increasing for reduction of weight or management of cardiometabolic risks. However, studies on high protein, low carbohydrate diet in Asians are limited. This study aimed to estimate whether the dietary ratio of protein (%) to carbohydrate (%) from total energy intake (p/c ratio) is associated with the risk of metabolic syndrome (MS) and its components in Korean adults using a long-term prospective cohort. A total of 6335 participants from the Korean Genome and Epidemiology Study, aged between 40 and 69 years, with no previous diagnosis of MS, cardiovascular diseases, or cancer at baseline (2001-2002) were followed until 2013. Dietary intake was measured using a validated semiquantitative food-frequency questionnaire. MS components were measured at baseline and every 2 years. During a mean of 7.7 years of follow up, 1198 (36.1%) men and 1169 (38.8%) women developed MS. The multivariate adjusted hazard ratio (HR) of incident MS was 1.43 (95% confidence interval, 1.09-1.89) for the highest compared lowest quintile of p/c ratio in men. When evaluating each component of MS, higher dietary p/c ratio was associated with an increased risk of high triglyceride and fasting glucose in men (HR for fifth vs. first quintile, 1.39 and 1.41 in Model 3, respectively). However, we observed no associations with incident MS and its components and dietary p/c ratio in women. In conclusion, we found that high dietary p/c ratio was associated with an increased risk of MS and its components (i.e., increased triglycerides and fasting glucose) in men. Our study suggested that even if the absolute amount of protein intake is not large, an increased p/c ratio may increase the risk of metabolic diseases.
C1 [Paik, Jean Kyung] Eulji Univ, Dept Food & Nutr, Seongnam 13135, South Korea.
   [Park, Mira; Jang, Suk-Yong] Eulji Univ, Sch Med, Dept Prevent Med, Deajeon 34824, South Korea.
   [Shin, Ji Eun] Woosuk Univ, Dept Liberal Arts, Jeollabuk Do 55338, South Korea.
   [Shin, Ji-Yeon] Kyungpook Natl Univ, Sch Med, Dept Prevent Med, Daegu 47944, South Korea.
C3 Eulji University; Eulji University; Woosuk University; Kyungpook
   National University (KNU)
RP Shin, JY (corresponding author), Kyungpook Natl Univ, Sch Med, Dept Prevent Med, Daegu 47944, South Korea.
EM jkpaik@eulji.ac.kr; mira@eulji.ac.kr; je_shin@woosuk.ac.kr;
   sukyong@eulji.ac.kr; nunmulgyupda@hanmail.net
OI Paik, Jean Kyung/0000-0003-0393-0353; Shin, Ji-Yeon/0000-0001-5434-0359;
   Jang, Suk-Yong/0000-0003-0558-1505; Park, Mira/0000-0003-3827-9089
FU Bio & Medical Technology Development Program of the National Research
   Foundation (NRF) - Korean government (MSIPMOHW) [2016M3A9B6904244,
   2016M3A9B6904246]
FX This research was supported by the Bio & Medical Technology Development
   Program of the National Research Foundation (NRF) and funded by the
   Korean government (MSIP&MOHW) (no. 2016M3A9B6904244, 2016M3A9B6904246).
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NR 42
TC 8
Z9 9
U1 0
U2 2
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD NOV
PY 2020
VL 12
IS 11
AR 3274
DI 10.3390/nu12113274
PG 13
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA OX7MO
UT WOS:000593744500001
PM 33114605
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Rodriguez, R
   Lee, A
   Mathis, KW
   Broome, HJ
   Thorwald, M
   Martinez, B
   Nakano, D
   Nishiyama, A
   Ryan, MJ
   Ortiz, RM
AF Rodriguez, Ruben
   Lee, Andrew
   Mathis, Keisa W.
   Broome, Hanna J.
   Thorwald, Max
   Martinez, Bridget
   Nakano, Daisuke
   Nishiyama, Akira
   Ryan, Michael J.
   Ortiz, Rudy M.
TI Angiotensin receptor and tumor necrosis factor-α activation contributes
   to glucose intolerance independent of systolic blood pressure in obese
   rats
SO AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
LA English
DT Article
DE hypertension; inflammation; insulin resistance; metabolic syndrome;
   renin-angiotensin system
ID SYSTEMIC-LUPUS-ERYTHEMATOSUS; INSULIN-RESISTANT RATS; CHRONIC
   KIDNEY-DISEASE; TYPE-2 DIABETIC-RATS; METABOLIC SYNDROME; TNF-ALPHA;
   RHEUMATOID-ARTHRITIS; RENAL INJURY; OXIDATIVE STRESS; II BLOCKADE
AB Pathological activation of the renin-angiotensin system and inflammation are associated with hypertension and the development of metabolic syndrome (MetS). The contributions of angiotensin receptor type 1 (AT1) activation, independent of blood pressure, and inflammation to glucose intolerance and renal damage are not well defined. Using a rat model of MetS, we hypothesized that the onset of glucose intolerance is primarily mediated by AT1 activation and inflammation independent of elevated systolic blood pressure (SBP). To address this hypothesis, we measured changes in SBP, adiposity, plasma glucose and triglyceride levels, and glucose tolerance in six groups of rats: 1) lean, strain control Long-Evans Tokushima Otsuka (LETO; n = 5), 2) obese Otsuka Long-Evans Tokushima Fatty (OLETF; n = 8), 3) OLETF + angiotensin receptor blocker (ARB; 10 mg olmesartan/kg; n = 8), 4) OLETF + tumor necrosis factor-alpha (TNF-alpha) inhibitor (ETAN; 1.25 mg etanercept/kg; n = 6), 5) OLETF + TNF-alpha inhibitor + angiotensin receptor blocker (ETAN + ARB; 1.25 mg etanercept/kg + 10 mg olmesartan/kg; n = 6), and 6) OLETF + calcium channel blocker (CCB; 5 mg amlodipine/kg; n = 7). ARB and ETAN + ARB were most effective at decreasing SBP in OLETF, and ETAN did not offer any additional reduction. Glucose tolerance improved in ARB, ETAN, and ETAN + ARB compared with OLETF, whereas CCB had no detectable effect. Furthermore, all treatments reduced adiposity, whereas ETAN alone normalized urinary albumin excretion. These results suggest that AT1 activation and inflammation are primary factors in the development of glucose intolerance in a setting of MetS and that the associated increase in SBP is primarily mediated by AT1 activation.
C1 [Rodriguez, Ruben; Lee, Andrew; Thorwald, Max; Martinez, Bridget; Ortiz, Rudy M.] Univ Calif Merced, Dept Mol & Cellular Biol, 5200 N Lake Rd, Merced, CA 95343 USA.
   [Mathis, Keisa W.] Univ North Texas, Hlth Sci Ctr, Dept Physiol & Anat, Ft Worth, TX USA.
   [Broome, Hanna J.] Mississippi Coll, Dept Biol Sci, Clinton, MS USA.
   [Ryan, Michael J.] Univ Mississippi, Med Ctr, Dept Physiol & Biophys, Jackson, MS 39216 USA.
   [Ryan, Michael J.] GV Sonny Montgomery Vet Affairs Med Ctr, Jackson, MS USA.
   [Nakano, Daisuke; Nishiyama, Akira] Kagawa Univ, Fac Med, Dept Pharmacol, Takamatsu, Kagawa, Japan.
   [Martinez, Bridget] St Georges Univ, Sch Med, St Georges, Grenada.
   [Martinez, Bridget] Los Alamos Natl Lab, Dept Phys & Engn, Los Alamos, NM USA.
C3 University of California System; University of California Merced;
   University of North Texas System; University of North Texas Denton;
   Mississippi College; University of Mississippi; University of
   Mississippi Medical Center; Kagawa University; United States Department
   of Energy (DOE); Los Alamos National Laboratory
RP Ortiz, RM (corresponding author), Univ Calif Merced, Dept Mol & Cellular Biol, 5200 N Lake Rd, Merced, CA 95343 USA.
EM rortiz@ucmerced.edu
RI NAKANO, DAISUKE/JWP-5663-2024
OI Rodriguez, Ruben/0009-0006-5222-7145; Nishiyama,
   Akira/0000-0001-5971-820X; Rodriguez, Ruben/0000-0001-8174-2556;
   Thorwald, Max/0000-0003-0095-5344
FU National Heart, Lung, and Blood Institute (NHLBI) [R01-HL-091767]; NIH
   [P01-HL-051971, P20-GM-104357]; American Heart Association [GIA2060203];
   Veterans Affairs Merit Award [BX002604-01A2]; NHLBI [HL-136684-A0];
   National Institute on Minority Health and Health Disparities
   [9T37-MD-001480]; Dennis R. Washington Graduate Achievement Scholarship
FX This work was partially supported by National Heart, Lung, and Blood
   Institute (NHLBI) Grant R01-HL-091767 to R. M. Ortiz, NIH Grants
   P01-HL-051971 and P20-GM-104357 to University of Mississippi Medical
   Center-Physiology, American Heart Association Grant-in-Aid GIA2060203,
   Veterans Affairs Merit Award BX002604-01A2, and NHLBI Grant HL-136684-A0
   to M. J. Ryan. A. Lee, R. Rodriguez, and B. Martinez were supported in
   part by National Institute on Minority Health and Health Disparities
   Grant 9T37-MD-001480. B. Martinez was supported by the Dennis R.
   Washington Graduate Achievement Scholarship.
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NR 61
TC 5
Z9 6
U1 0
U2 2
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 1931-857X
EI 1522-1466
J9 AM J PHYSIOL-RENAL
JI Am. J. Physiol.-Renal Physiol.
PD OCT
PY 2018
VL 315
IS 4
BP F1081
EP F1090
DI 10.1152/ajprenal.00156.2018
PG 10
WC Physiology; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology; Urology & Nephrology
GA GX3LQ
UT WOS:000447626000031
PM 29993275
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Ferré, N
   Feliu, A
   García-Heredia, A
   Marsillach, J
   París, N
   Zaragoza-Jordana, M
   Mackness, B
   Mackness, M
   Escribano, J
   Closa-Monasterolo, R
   Joven, J
   Camps, J
AF Ferre, Natalia
   Feliu, Albert
   Garcia-Heredia, Anabel
   Marsillach, Judit
   Paris, Neus
   Zaragoza-Jordana, Marta
   Mackness, Bharti
   Mackness, Michael
   Escribano, Joaquin
   Closa-Monasterolo, Ricardo
   Joven, Jorge
   Camps, Jordi
TI Impaired paraoxonase-1 status in obese children. Relationships with
   insulin resistance and metabolic syndrome
SO CLINICAL BIOCHEMISTRY
LA English
DT Article
DE Insulin resistance; Metabolic syndrome; Obesity; Paraoxonase-1
ID BODY-MASS INDEX; HIGH-DENSITY-LIPOPROTEINS; SERUM PARAOXONASE; OXIDATIVE
   STRESS; CHILDHOOD OBESITY; SPANISH ADOLESCENTS; FAT COMPOSITION; PON1;
   RISK; ASSOCIATION
AB Objectives: To investigate the relationships between serum paraoxonase-1 (PON1), insulin resistance, and metabolic syndrome (MetS) in childhood obesity.
   Design and methods: We studied 110 obese children and 36 non-obese children with a similar gender and age distribution. We measured serum PON1 activity against 5-thiobutyl butyrolactone (TBBLase) and against paraoxon (paraoxonase). PON1 concentration was measured separately as were the levels of several standard metabolic variables. The homeostasis model assessment (HOMA) index was calculated as an estimate of insulin resistance.
   Results: TBBLase was significantly decreased in obese children (P = 0.008), while paraoxonase activity and PON1 concentrations showed non-significant trends towards decrease and increase, respectively (P = 0.054 and P = 0.060). TBBLase and paraoxonase specific activities were significantly decreased (P = 0.004 and P = 0.018, respectively). TBBLase specific activity was inversely associated with BMI, percentage body fat, insulin, HOMA, triglycerides, and C-reactive protein, and directly associated with HDL-cholesterol. Paraoxonase specific activity showed similar associations with BMI, percentage fat, HDL-cholesterol, and C-reactive protein. Obese children with MetS had lower TBBLase activities than obese children without MetS (P = 0.018). Linear regression analyses showed that TBBLase was independently associated with HDL-cholesterol, BMI, percentage body fat and PON1(55) polymorphism, but paraoxonase activity was associated only with PON1(192) Polymorphism.
   Conclusions: Our results suggest that PON1 may play a role in the onset and development of metabolic alterations in childhood obesity leading to diabetes and cardiovascular disease later in life. However, being derived from statistical association study, this finding cannot be seen as showing cause-effect (C) 2013 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
C1 [Ferre, Natalia; Feliu, Albert; Paris, Neus; Zaragoza-Jordana, Marta; Escribano, Joaquin; Closa-Monasterolo, Ricardo] Univ Rovira & Virgili, Fac Med & Ciencies Salut, Inst Invest Sanitaria Pere Virgili, Unitat Pediat, E-43201 Reus, Spain.
   [Feliu, Albert; Paris, Neus; Escribano, Joaquin] Hosp Univ St Joan, Serv Pediat, Reus 43201, Catalonia, Spain.
   [Garcia-Heredia, Anabel; Mackness, Bharti; Mackness, Michael; Joven, Jorge; Camps, Jordi] Univ Rovira & Virgili, Hosp Univ St Joan, Inst Invest Sanitaria Pere Virgili, Unitat Recerca Biomed, E-43201 Reus, Spain.
   [Marsillach, Judit] Univ Washington, Dept Med, Seattle, WA USA.
   [Marsillach, Judit] Univ Washington, Dept Genome Sci, Seattle, WA 98195 USA.
C3 Universitat Rovira i Virgili; Institut d'Investigacio Sanitaria Pere
   Virgili (IISPV); Universitat Rovira i Virgili; Institut d'Investigacio
   Sanitaria Pere Virgili (IISPV); University of Washington; University of
   Washington Seattle; University of Washington; University of Washington
   Seattle
RP Camps, J (corresponding author), Hosp Univ St Joan, Unitat Recerca Biomed, C St Joan S-N, Reus 43201, Catalonia, Spain.
EM jcamps@grupsagessa.com
RI Garcia-Heredia, Anabel/ABC-3161-2021; Zaragoza-Jordana,
   Marta/AAL-1342-2020; Ferre, Natalia/AGA-5684-2022; Marsillach,
   Judit/I-1329-2015; Escribano, Joaquin/ABD-6604-2020; Camps,
   Jordi/AAG-3080-2020; Joven, Jorge/B-3360-2016
OI Garcia-Heredia, Anabel/0000-0003-2876-1779; Joven,
   Jorge/0000-0003-2749-4541; Zaragoza-Jordana, Marta/0000-0001-9704-6950;
   Ferre, Natalia/0000-0002-2838-1525; Escribano,
   Joaquin/0000-0002-5041-459X
FU Instituto de Salud Carlos III, Madrid, Spain [PI 08/1381, 08/1032,
   10/0082, 11/2187]
FX This study was supported by grants from the Instituto de Salud Carlos
   III (PI 08/1381, 08/1032, 10/0082, 11/2187), Madrid, Spain. Editorial
   assistance was by Dr. Peter R. Turner of Tscimed.com.
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NR 56
TC 42
Z9 45
U1 0
U2 22
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0009-9120
EI 1873-2933
J9 CLIN BIOCHEM
JI Clin. Biochem.
PD DEC
PY 2013
VL 46
IS 18
BP 1830
EP 1836
DI 10.1016/j.clinbiochem.2013.08.020
PG 7
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA 274HA
UT WOS:000328596200012
PM 24028901
DA 2025-06-11
ER

PT J
AU Saikia, L
   Talukdar, NC
   Dutta, PP
AF Saikia, Lunasmrita
   Talukdar, Nayaran Chandra
   Dutta, Partha Pratim
TI Exploring the Therapeutic Role of Flavonoids Through AMPK Activation in
   Metabolic Syndrome: A Narrative Review
SO PHYTOTHERAPY RESEARCH
LA English
DT Review
DE diabetes; metabolic syndrome; natural products; obesity; signalling
   pathways
ID DIET-INDUCED OBESITY; INSULIN-RESISTANCE; IMPROVES GLUCOSE; OXIDATIVE
   STRESS; SKELETAL-MUSCLE; CARDIOVASCULAR-DISEASE; SIGNALING PATHWAY;
   LIPID-METABOLISM; RICH EXTRACT; QUERCETIN
AB Metabolic syndrome (MetS) is a cluster of interrelated metabolic abnormalities that significantly elevate the risk of cardiovascular disease, obesity, and diabetes. Flavonoids, a diverse class of bioactive polyphenolic compounds found in plant-derived foods and beverages, have garnered increasing attention as potential therapeutic agents for improving metabolic health. This review provides a comprehensive analysis of the therapeutic effects of flavonoids in the context of the MetS, with a particular focus on their modulation of the AMP-activated protein kinase (AMPK) pathway. AMPK serves as a central regulator of cellular energy balance, glucose metabolism, and lipid homeostasis, making it a critical target for metabolic intervention. Through a systematic review of the literature up to April 2024, preclinical studies across various flavonoid subclasses, including flavonols, and flavan-3-ols, were analysed to elucidate their mechanistic roles in metabolic regulation. Many studies suggests that flavonoids enhance glycolipid metabolism by facilitating glucose transporter 4 (GLUT4) translocation and activating the AMPK pathway, thereby improving glycemic control in diabetes models. In obesity-related studies, flavonoids demonstrated significant inhibitory effects on lipid synthesis, reduced adipogenesis, and attenuated proinflammatory cytokine secretion via AMPK activation. These findings show the broad therapeutic potential of flavonoids in addressing the MetS and its associated disorders. While these preclinical insights highlight flavonoids as promising natural agents for metabolic health improvement, it is important to note that their excessive concentrations may disrupt these pathways, potentially leading to metabolic imbalance and cytotoxicity. Further studies and clinical trials are essential to determine optimal dosing regimens, formulations, and the long-term safety and efficacy of flavonoids. This review highlights the importance of flavonoids for natural interventions targeting MetS and its comorbidities, offering a foundation for future translational research.
C1 [Saikia, Lunasmrita; Dutta, Partha Pratim] Assam Down Town Univ, Fac Pharmaceut Sci, Gauhati, Assam, India.
   [Talukdar, Nayaran Chandra] Assam Down Town Univ, Fac Sci, Gauhati, Assam, India.
C3 Assam Down Town University; Assam Down Town University
RP Dutta, PP (corresponding author), Assam Down Town Univ, Fac Pharmaceut Sci, Gauhati, Assam, India.
EM partha184@gmail.com
RI Dutta, Partha/KHE-5018-2024
OI Dutta, Partha Pratim/0000-0003-0907-3030
FU Assam down town University, Assam, India
FX We thank Assam down town University, Assam, India for providing the
   necessary facilities and financial support.
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NR 137
TC 2
Z9 2
U1 8
U2 8
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0951-418X
EI 1099-1573
J9 PHYTOTHER RES
JI Phytother. Res.
PD MAR
PY 2025
VL 39
IS 3
BP 1403
EP 1421
DI 10.1002/ptr.8428
EA JAN 2025
PG 19
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA Z7O0E
UT WOS:001392958700001
PM 39789806
DA 2025-06-11
ER

PT J
AU Chiu, H
   Lee, MY
   Wu, PY
   Huang, JC
   Chen, SC
AF Chiu, Hsuan
   Lee, Mei-Yueh
   Wu, Pei-Yu
   Huang, Jiun-Chi
   Chen, Szu-Chia
TI Development of Metabolic Syndrome Decreases Bone Mineral Density T-Score
   of Calcaneus in Foot in a Large Taiwanese Population Follow-Up Study
SO JOURNAL OF PERSONALIZED MEDICINE
LA English
DT Article
DE metabolic syndrome; osteoporosis; follow-up
ID GLYCATION END-PRODUCTS; OXIDATIVE STRESS; BODY-SIZE; ASSOCIATION;
   OSTEOPOROSIS; WOMEN; OLDER; MEN; FRACTURE; RISK
AB Studies have suggested that there may be common pathogenic pathways linking osteoporosis and metabolic syndrome (MetS) due to the multiple risk factors for atherosclerotic cardiovascular disease caused by MetS. However, results on the association between MetS and bone health are inconsistent and sometimes contradictory. In this study, we aimed to investigate the associations between the effects of MetS risk factors and bone mineral density (BMD) T-score in a longitudinal study of 27,033 participants from the Taiwan Biobank with a follow-up period of 4 years. BMD of the calcaneus was measured in the non-dominant foot using ultrasound in the Taiwanese population. The overall prevalence rates of MetS were 16.7% (baseline) and 21.2% (follow-up). The participants were stratified into four groups according to the status of MetS (no/yes at baseline and follow-up). We investigated associations between MetS and its five components (baseline, follow-up) with BMD Delta T-score and found that the (no, yes) MetS group, (no, yes) abdominal obesity group, (no, yes) hypertriglyceridemia group, and (no, yes) low high-density lipoprotein (HDL) cholesterol group had the lowest Delta T-score. Furthermore, in the (no, yes) MetS group, high Delta waist circumference (p = 0.009), high Delta triglycerides (p = 0.004), low Delta HDL cholesterol (p = 0.034), and low Delta systolic blood pressure (p = 0.020) were significantly associated with low Delta T-score, but Delta fasting glucose was not. In conclusion, in this large population-based cohort study, our data provide evidence that the development of MetS is strongly associated with increased rates of BMD loss in the Taiwanese population. This suggests that the prevention of MetS should be taken into consideration in the prevention of osteoporosis in the Taiwanese population.
C1 [Chiu, Hsuan] Kaohsiung Chang Gung Mem Hosp, Dept Gen Med, Kaohsiung 833, Taiwan.
   [Lee, Mei-Yueh] Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Div Endocrinol & Metab, Dept Internal Med, Kaohsiung 807, Taiwan.
   [Lee, Mei-Yueh; Huang, Jiun-Chi; Chen, Szu-Chia] Kaohsiung Med Univ, Coll Med, Fac Med, Kaohsiung 807, Taiwan.
   [Wu, Pei-Yu; Huang, Jiun-Chi; Chen, Szu-Chia] Kaohsiung Med Univ, Kaohsiung Municipal Siaogang Hosp, Dept Internal Med, Kaohsiung 812, Taiwan.
   [Wu, Pei-Yu; Huang, Jiun-Chi; Chen, Szu-Chia] Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Div Nephrol, Dept Internal Med, Kaohsiung 807, Taiwan.
   [Chen, Szu-Chia] Kaohsiung Med Univ, Res Ctr Environm Med, Kaohsiung 807, Taiwan.
C3 Chang Gung Memorial Hospital; Kaohsiung Medical University; Kaohsiung
   Medical University Hospital; Kaohsiung Medical University; Kaohsiung
   Medical University; Kaohsiung Municipal Siao-Gang Hospital; Kaohsiung
   Medical University; Kaohsiung Medical University Hospital; Kaohsiung
   Medical University
RP Chen, SC (corresponding author), Kaohsiung Med Univ, Coll Med, Fac Med, Kaohsiung 807, Taiwan.; Chen, SC (corresponding author), Kaohsiung Med Univ, Kaohsiung Municipal Siaogang Hosp, Dept Internal Med, Kaohsiung 812, Taiwan.; Chen, SC (corresponding author), Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Div Nephrol, Dept Internal Med, Kaohsiung 807, Taiwan.; Chen, SC (corresponding author), Kaohsiung Med Univ, Res Ctr Environm Med, Kaohsiung 807, Taiwan.
EM mickey990055@gmail.com; lovellelee@hotmail.com; wpuw17@gmail.com;
   karajan77@gmail.com; scarchenone@yahoo.com.tw
RI Huang, Jiun-Chi/IAQ-1908-2023; 蘇, 河名/AAE-9843-2019
OI Chen, Szu-Chia/0000-0002-1610-4184; Lee, Mei Yueh/0000-0001-8950-064X;
   Huang, Jiun-Chi/0000-0002-5897-2860
FU Research Center for Environmental Medicine, Kaohsiung Medical
   University, Kaohsiung, Taiwan; Kaohsiung Medical University Research
   Center [KMU-TC109A01-1]; Kaohsiung Municipal Siaogang Hospital
   [S-109-04]
FX This work was supported partially by the Research Center for
   Environmental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
   from The Featured Areas Research Center Program within the framework of
   the Higher Education Sprout Project by the Ministry of Education (MOE)
   in Taiwan and by Kaohsiung Medical University Research Center Grant
   (KMU-TC109A01-1), and Kaohsiung Municipal Siaogang Hospital (S-109-04).
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NR 75
TC 5
Z9 6
U1 0
U2 4
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2075-4426
J9 J PERS MED
JI J. Pers. Med.
PD MAY
PY 2021
VL 11
IS 5
AR 439
DI 10.3390/jpm11050439
PG 14
WC Health Care Sciences & Services; Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Health Care Sciences & Services; General & Internal Medicine
GA SH7PF
UT WOS:000654325000001
PM 34065445
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Yossef, RR
   Al-Yamany, MF
   Saad, MA
   El-Sahar, AE
AF Yossef, Rasha R.
   Al-Yamany, Mohamed F.
   Saad, Muhammed A.
   El-Sahar, Ayman E.
TI Neuroprotective effects of vildagliptin on drug induced Alzheimer's
   disease in rats with metabolic syndrome: Role of hippocampal klotho and
   AKT signaling pathways
SO EUROPEAN JOURNAL OF PHARMACOLOGY
LA English
DT Article
DE Alzheimer's disease; Metabolic syndrome; GLP-1; Vildagliptin; Klotho;
   AKT pathway
ID INSULIN-RESISTANCE; COGNITIVE DEFICITS; DPP4 INHIBITOR; MOUSE MODEL;
   RECEPTOR; CELLS; RIVASTIGMINE; SAXAGLIPTIN; ACTIVATION; EXPRESSION
AB Growing evidences suggest the presence of several similarities in the molecular mechanisms underlying the neurodegenerative diseases and metabolic abnormalities. Adults who develop Metabolic Syndrome (MS) are at a higher risk of developing Alzheimer's disease (AD). Pharmacological agents, like dipeptidyl peptidase-4 (DPP-4) inhibitors that increase the levels of glucagon like peptide 1 (GLP-1) and ameliorate symptoms of MS, have become an auspicious candidate as disease modifying agents in the treatment of AD. The present study investigates the beneficial effects of Vildagliptin, a DPP-4 inhibitor in counteracting cognitive decline in different models of dementia targeting the AKT, JAK/STAT signaling pathways and hippocampal Klotho expression, to judge the neuroprotective, anti-apoptotic and anti-inflammatory effects of the drug. Cognitive decline was induced by either administration of high fat high sugar (HFHS) diet for 45 days alone, or with oral administration of AlCl3 (100 mg/kg/day) for 60 days. Rats were orally administered Vildagliptin (10 mg/kg) for 60 days along with AlCl3 administration. Vildagliptin treatment improved spatial memory and activities in morris water maze (MWM) test and open field test respectively. Results revealed an increase of both hippocampal klotho and Bcl-2 expressions along with an increase in both AKT and ERK1/2 phosphorylation. In contrast, Vildagliptin treatment decreased hippocampal contents of inflammatory, apoptotic and oxidative stress biomarkers as TNF-alpha, caspase-3 and FOXO1 along with restoring metabolic abnormalities. A significant decrease in BAX expressions with JAK2/STAT3 inhibition was observed. These findings demonstrate that the neuroprotective role of vildagliptin is possibly via modulating Klotho protein together with AKT pathway.
C1 [Yossef, Rasha R.] October 6 Univ, Dept Pharmacol & Toxicol, Fac Pharm, Giza, Egypt.
   [Al-Yamany, Mohamed F.; El-Sahar, Ayman E.] Cairo Univ, Dept Pharmacol & Toxicol, Fac Pharm, Cairo, Egypt.
   [Saad, Muhammed A.] Newgiza Univ, Sch Pharm, Cairo, Egypt.
C3 Egyptian Knowledge Bank (EKB); October 6 University (O6U); Egyptian
   Knowledge Bank (EKB); Cairo University; Newgiza University (NGU)
RP El-Sahar, AE (corresponding author), Cairo Univ, Dept Pharmacol & Toxicol, Fac Pharm, Cairo, Egypt.
EM rasha.re.yossef@std.pharma.cu.edu.eg; mohammedelyamany@gmail.com;
   mohammed.abdellatif@pharma.cu.edu.eg; ayman.elsahar@pharma.cu.edu.eg
RI Elsahar, Ayman/AGD-7849-2022
OI Saad, Muhammed/0000-0001-6017-0069; El-Sahar, Ayman/0000-0002-7597-2352
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NR 45
TC 38
Z9 39
U1 1
U2 8
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0014-2999
EI 1879-0712
J9 EUR J PHARMACOL
JI Eur. J. Pharmacol.
PD DEC 15
PY 2020
VL 889
AR 173612
DI 10.1016/j.ejphar.2020.173612
PG 11
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA PF0AD
UT WOS:000598722000007
PM 33035520
DA 2025-06-11
ER

PT J
AU Baghshini, MR
   Nikbakht-Jam, I
   Mohaddes-Ardabili, H
   Pasdar, A
   Avan, A
   Tayefi, M
   Sahebkar, A
   Sheikh-Andalibi, MS
   Ferns, GA
   Ghayour-Mobarhan, M
AF Baghshini, Mohammad Reza
   Nikbakht-Jam, Irandokht
   Mohaddes-Ardabili, Hossein
   Pasdar, Alireza
   Avan, Amir
   Tayefi, Maryam
   Sahebkar, Amirhossein
   Sheikh-Andalibi, Mohammad Sobhan
   Ferns, Gordon A.
   Ghayour-Mobarhan, Majid
TI Higher prevalence of metabolic syndrome among male employees of a gas
   refinery than in their counterparts in nonindustrial environments
SO ASIAN BIOMEDICINE
LA English
DT Article
DE Cardiovascular disease; industrial employees; metabolic syndrome;
   obesity
ID AMERICAN-HEART-ASSOCIATION; PARTICULATE AIR-POLLUTION;
   SOCIOECONOMIC-STATUS; BLOOD-PRESSURE; CARDIOVASCULAR-DISEASE;
   INDUSTRIAL-WORKERS; HEALTH; STRESS; RISK; METAANALYSIS
AB Background: Occupation and working conditions may affect the risk of developing metabolic syndrome (MetS), an important risk factor for diabetes and cardiovascular disease (CVD).
   Objective: To investigate the prevalence of MetS and its risk factors in employees in an industrial workplace and compare them with those in employees from a nonindustrial setting.
   Methods: Male employees (n = 757) from a gas-refinery and 2700 adult men from the general population of whom 750 were nonindustrial employees (Khorasan province, Iran), were evaluated for CVD risk factors, including those used to define MetS. Individuals were matched for age and educational attainment, and 670 industrial and 681 nonindustrial employees were included in the final analysis. International Diabetes Federation (IDF) and Adult Treatment Panel (ATP) III criteria were used for diagnosis of MetS. We compared MetS and its risk factors between the two groups.
   Results: There were more gas refinery employees with a body mass index > 30 kg/m(2), abdominal obesity, and a high fasting blood glucose level than nonindustrial employees (P < 0.01). A diagnosis of MetS was significantly more likely in refinery workers than in nonindustrial employees (OR 1.38, 95% CI 1.10 to 1,737; P = 0.005). Scores of IDF and ATP III criteria in the refinery employees were significantly higher than for the nonindustrial employees (P < 0.01). The prevalence of hypertriglyceridemia in the refinery employees tended to be higher than in nonindustrial employees, but the difference was not quite significant (P = 0.052). Blood pressure in nonindustrial employees was significantly higher than in refinery employees (P < 0.001).
   Conclusions: The prevalence of MetS among male gas refinery employees was higher than for male nonindustrial employees.
C1 [Baghshini, Mohammad Reza; Nikbakht-Jam, Irandokht; Mohaddes-Ardabili, Hossein; Tayefi, Maryam; Ghayour-Mobarhan, Majid] Mashhad Univ Med Sci, Sch Med, Metab Res Ctr, Mashhad 91388, Iran.
   [Pasdar, Alireza; Avan, Amir] Mashhad Univ Med Sci, Sch Med, Dept Modern Sci & Technol, Mashhad 91388, Iran.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Sch Pharm, Biotechnol Res Ctr, Mashhad 91388, Iran.
   [Sheikh-Andalibi, Mohammad Sobhan] Mashhad Univ Med Sci, Cardiovasc Res Ctr, Student Res Comm, Fac Med, Mashhad 91388, Iran.
   [Ferns, Gordon A.] Univ Sussex, Brighton & Sussex Med Sch, Div Med Educ, Brighton BN1 9PX, E Sussex, England.
C3 Mashhad University of Medical Sciences; Mashhad University of Medical
   Sciences; Mashhad University of Medical Sciences; Mashhad University of
   Medical Sciences; University of Brighton; University of Sussex
RP Ghayour-Mobarhan, M (corresponding author), Mashhad Univ Med Sci, Sch Med, Biochem & Nutr Res Ctr, Mashhad 91388, Iran.
EM ghayourm@mums.ac.ir
RI shahidsales, soudabe/AAY-2920-2020; Sahebkar, Amirhossein/B-5124-2018;
   Ghayour-Mobarhan, Majid/AAY-5963-2020; Sheikh Andalibi,
   Mohammadsobhan/N-4411-2015
OI naseri, shahrokh/0000-0001-8974-2120; Nikbakht Jam,
   Irandokht/0000-0002-4371-4586; Sheikh Andalibi,
   Mohammadsobhan/0000-0002-4895-1214; tayefi, maryam/0000-0003-4637-7754;
   Pasdar, Alireza/0000-0002-7864-9729
FU Mashhad University of Medical Science, Mashhad, Iran
FX We appreciate the contributions of and thank Mahmoud Ebrahimi, Mohsen
   Mohebati, Alireza Heidari-Bakavoli and Mahsa Eghbali for conducting and
   collecting data for the study. We thank the volunteers for this study
   and appreciate their participation. This work was supported by a grant
   from the Mashhad University of Medical Science, Mashhad, Iran.
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NR 30
TC 4
Z9 4
U1 0
U2 5
PU WALTER DE GRUYTER GMBH
PI BERLIN
PA GENTHINER STRASSE 13, D-10785 BERLIN, GERMANY
SN 1905-7415
EI 1875-855X
J9 ASIAN BIOMED
JI Asian Biomed.
PD JUN
PY 2017
VL 11
IS 3
BP 227
EP 234
DI 10.5372/1905-7415.1103.553
PG 8
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA FW4MR
UT WOS:000425288200004
DA 2025-06-11
ER

PT J
AU Denimal, D
   Monier, S
   Brindisi, MC
   Petit, JM
   Bouillet, B
   Nguyen, A
   Demizieux, L
   Simoneau, I
   de Barros, JPP
   Vergès, B
   Duvillard, L
AF Denimal, Damien
   Monier, Serge
   Brindisi, Marie-Claude
   Petit, Jean-Michel
   Bouillet, Benjamin
   Nguyen, Amandine
   Demizieux, Laurent
   Simoneau, Isabelle
   de Barros, Jean-Paul Pais
   Verges, Bruno
   Duvillard, Laurence
TI Impairment of the Ability of HDL From Patients With Metabolic Syndrome
   but Without Diabetes Mellitus to Activate eNOS Correction by S1P
   Enrichment
SO ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
LA English
DT Article
DE eNOS; HDL; metabolic syndrome; sphingosine
ID HIGH-DENSITY-LIPOPROTEIN; ELEVATED OXIDATIVE STRESS; OXIDE SYNTHASE
   ACTIVATION; APOLIPOPROTEIN-A-I; SPHINGOSINE 1-PHOSPHATE;
   INSULIN-RESISTANCE; SPHINGOSINE-1-PHOSPHATE CONTENT; CHOLESTEROL EFFLUX;
   CELL FUNCTION; PARTICLES
AB Objective-High-density lipoprotein (HDL) from nondiabetic patients with metabolic syndrome (MetS) displays abnormalities in their lipidome, such as triglyceride enrichment and sphingosine-1-phosphate depletion. We hypothesized that these abnormalities could impair the ability of HDL to stimulate endothelial nitric oxide synthase (eNOS).
   Approach and Results-Compared with HDL from control subjects, HDL from normoglycemic patients with MetS was 39% richer in triglycerides (P<0.01) and 15% poorer in sphingosine-1-phosphate (P<0.05; n=23 in each group). eNOS activity, assessed by the conversion of L-[3H] arginine to L-[3H] citrulline, was 69% lower in human umbilical vein endothelial cells incubated with HDL from MetS patients than in cells incubated with HDL from controls (P<0.0001). In addition, the activating phosphorylation of eNOS at serine (Ser) 1177 and of Akt (protein kinase B) at Ser473 was 37% (P<0.001) and 39% (P<0.05) lower, respectively, with HDL from MetS patients. Sphingosine-1-phosphate enrichment of HDL from MetS patients restored their ability to stimulate eNOS activity (P<0.05), in relation with a significant increase in eNOS phosphorylation at Ser1177 (P<0.05) and in Akt phosphorylation at Ser473 (P=0.05). By contrast, triglyceride enrichment of HDL from control subjects did not modify eNOS activity (P=0.90) and phosphorylation at Ser1177 (P=0.87).
   Conclusions-We provide evidence that the activation of eNOS by HDL is decreased in MetS patients before the appearance of diabetes mellitus and that sphingosine-1-phosphate depletion of HDL is the main factor responsible for this defect. This has important consequences on the impairment of HDL functionality and antiatherogenic properties in these patients.
C1 [Denimal, Damien; Monier, Serge; Brindisi, Marie-Claude; Petit, Jean-Michel; Bouillet, Benjamin; Nguyen, Amandine; Demizieux, Laurent; Simoneau, Isabelle; Verges, Bruno; Duvillard, Laurence] Univ Bourgogne Franche Comte, LNC UMR1231, Dijon, France.
   [Denimal, Damien; Monier, Serge; Brindisi, Marie-Claude; Petit, Jean-Michel; Bouillet, Benjamin; Demizieux, Laurent; Simoneau, Isabelle; de Barros, Jean-Paul Pais; Verges, Bruno; Duvillard, Laurence] INSERM, LNC UMR1231, Dijon, France.
   [Denimal, Damien; Demizieux, Laurent] Univ Hosp Dijon Burgundy, Dept Biochem, 2 Rue Angelique Ducoudray,BP 37013, F-21070 Dijon, France.
   [Brindisi, Marie-Claude; Petit, Jean-Michel; Bouillet, Benjamin; Nguyen, Amandine; Simoneau, Isabelle; Verges, Bruno] Univ Hosp Dijon Burgundy, Dept Endocrinol & Metab Dis, Dijon, France.
   [de Barros, Jean-Paul Pais] Lipid Analyt Platform, Batiment B3, Dijon, France.
C3 Universite Bourgogne Europe; Institut Agro; AgroSup Dijon; Institut
   National de la Sante et de la Recherche Medicale (Inserm); Institut
   National de la Sante et de la Recherche Medicale (Inserm); Universite
   Bourgogne Europe; Institut Agro; AgroSup Dijon; Universite Bourgogne
   Europe; CHU Dijon Bourgogne; Universite Bourgogne Europe; CHU Dijon
   Bourgogne; Universite Bourgogne Europe; Institut Agro; AgroSup Dijon
RP Denimal, D (corresponding author), Univ Hosp Dijon Burgundy, Dept Biochem, 2 Rue Angelique Ducoudray,BP 37013, F-21070 Dijon, France.
EM damien.denimal@chu-dijon.fr
RI Bouillet, Benjamin/AAG-8165-2019
OI PAIS DE BARROS, Jean-Paul/0000-0002-5124-2283; simoneau,
   isabelle/0000-0002-9092-1908
FU University of Burgundy Franche-Comte; Regional Council of Burgundy;
   National Institute of Health; Medical Research (Institut National de la
   Sante et de la Recherche Medicale [INSERM]); French National Research
   Agency (ANR) under the program Investissements d'Avenir
   [ANR-11-LABX-0021]
FX This investigation was supported by the University of Burgundy
   Franche-Comte, the Regional Council of Burgundy (Conseil Regional de
   Bourgogne), and the National Institute of Health and Medical Research
   (Institut National de la Sante et de la Recherche Medicale [INSERM]).
   The authors acknowledge grants from the French National Research Agency
   (ANR) under the program Investissements d'Avenir with reference
   ANR-11-LABX-0021 (LipSTIC Labex).
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NR 42
TC 45
Z9 49
U1 0
U2 11
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1079-5642
EI 1524-4636
J9 ARTERIOSCL THROM VAS
JI Arterioscler. Thromb. Vasc. Biol.
PD MAY
PY 2017
VL 37
IS 5
BP 804
EP +
DI 10.1161/ATVBAHA.117.309287
PG 14
WC Hematology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Hematology; Cardiovascular System & Cardiology
GA EV7EX
UT WOS:000401939000016
PM 28360087
OA Bronze
DA 2025-06-11
ER

PT J
AU Dong, XM
   Liao, Y
   Chen, KH
   Fang, Y
   Li, WG
   Chen, JD
   You, LX
   Li, SP
AF Dong, Xingmo
   Liao, Ying
   Chen, Kaihong
   Fang, Yong
   Li, Weiguo
   Chen, Jiande
   You, Lixia
   Li, Shuiping
TI Elevated red blood cell distribution width in benign prostatic
   hyperplasia patients with metabolic syndrome
SO INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
LA English
DT Article
DE Red blood cell distribution width; benign prostatic hyperplasia;
   metabolic syndrome; inflammation
ID CORONARY-ARTERY-DISEASE; URINARY-TRACT SYMPTOMS; INFLAMMATION;
   MORTALITY; PROGRESSION; COHORT
AB Red blood distribution width (RDW) is a novel prognostic marker that reflects oxidative stress and inflammation in patients. Chronic inflammation has been proposed as a candidate mechanism between benign prostatic hyperplasia (BPH) and metabolic syndrome (MetS). However, the relationship between RDW and MetS in BPH patients is unclear. Men aged 50 year-old or older with BPH were recruited into the study. The BPH patients were classified as MetS group and non-MetS group. 69 patients without BPH and MetS were as the control group. The clinical information and RDW were measured to identify their relationship. MetS was diagnosed in 34% of the patients. The RDW values were found to be higher in the BPH group than in the control group [(13.3 +/- 0.8) vs. (12.6 +/- 0.8), P < 0.001]. The total prostate volume (TPV) and post void residual (PVR) urine volume were significantly higher in subject with MetS than in non-MetS and related with the number of metabolic abnormalities. High serum triglyceride and low serum high-density lipoprotein cholesterol (HDL-C) levels were significantly associated with TPV even adjusting for age (adjusted r = 0.373, P < 0.001, and adjusted r = -0.425, P < 0.001, respectively). There was a significant correlation between RDW and TPV (r = 0.370, P < 0.001), Body mass index (BMI) (r = 0.367, P < 0.001) and MetS (r = 0.276, P < 0.001). The data indicated that RDW was independently correlated with the presence of MetS (odd ratio 1.226, 95% confidence intervals 0.89-1.87, P < 0.001). MetS is associated with BPH development in men. The RDW level is significantly higher in patients with BPH than that in control. RDW is an independent predictor of MetS in BPH patients.
C1 [Dong, Xingmo; Chen, Jiande] Fujian Med Univ, Affiliated Longyan Hosp 1, Dept Urol, Fujian 364000, Peoples R China.
   [Liao, Ying; Chen, Kaihong; Fang, Yong; Li, Weiguo] Fujian Med Univ, Affiliated Longyan Hosp 1, Dept Cardiol, Longyan 364000, Fujian, Peoples R China.
   [You, Lixia; Li, Shuiping] Fujian Med Univ, Affiliated Longyan Hosp 1, Dept Ultrasonog, Fujian 364000, Peoples R China.
C3 Fujian Medical University; Fujian Medical University; Fujian Medical
   University
RP Liao, Y (corresponding author), Fujian Med Univ, Affiliated Longyan Hosp 1, Dept Cardiol, 104 Jiuyi North Rd, Longyan 364000, Fujian, Peoples R China.
EM wingjays@163.com
RI liao, ying/O-5321-2016; Li, Weiguo/H-8502-2019
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NR 22
TC 7
Z9 8
U1 0
U2 5
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 1940-5901
J9 INT J CLIN EXP MED
JI Int. J. Clin. Exp. Med.
PY 2015
VL 8
IS 1
BP 1213
EP 1219
PG 7
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA CB8RA
UT WOS:000349897200148
PM 25785115
DA 2025-06-11
ER

PT J
AU Martino, F
   Martino, E
   Albanese, CV
   Paravati, V
   Niglio, T
   Zanoni, C
   Puddu, PE
AF Martino, Francesco
   Martino, Eliana
   V. Albanese, Carlina
   Paravati, Vincenzo
   Niglio, Tarcisio
   Zanoni, Cristina
   Puddu, Paolo Emilio
TI The Abnormal Ratio of Android-Gynoid Fat, Measured by Dual-Energy X-Ray
   Absorptiometry (DEXA) Scans, is Moderately Useful for Diagnosing
   Metabolic Syndrome in Children and Adolescents
SO JOURNAL OF CLINICAL DENSITOMETRY
LA English
DT Article
DE DEXA; A; G ratio; Metabolic syndrome; Children; Dyslipidemic risk
ID INSULIN-RESISTANCE; CARDIOVASCULAR-DISEASE; BODY-COMPOSITION; URIC-ACID;
   OXIDATIVE STRESS; VISCERAL FAT; RISK-FACTORS; OBESITY; ATHEROSCLEROSIS;
   ASSOCIATION
AB Background and Aim: Abnormal android to-gynoid-fat ratio (A/G) measured by dual-energy X-ray absorptiometry (DEXA) in children may index cardiometabolic abnormalities including metabolic syndrome (MS) whose diagnosis was not done based on age, sex, and Country specific methods in previous studies. Methodology: Anthropometric measures, blood pressure, liver function, biochemical and lipid and glucose profile were obtained in 82 consecutive children and adolescents (43 girls and 39 boys, aged 5-14 years) out of a consecutive series of 119 of all ages who resided in an urban area and were screened for obesity and/or dyslipidemia during 4 years and submitted to DEXA. The diagnosis of MS was based on Country specific >90th percentile for waist circumference, triglycerides, blood glucose, and systolic or diastolic pressures and <10th percentile for HDL cholesterol and coded 1 when 3 of 5 abnormal components were present. In a different MS definition waist circumference was withhold. Results and Conclusions: There were statistically significant (0.001<p<0.05) differences among abnormal DEXA values of the A/G mass ratio (>1), consisting in higher BMI, arm, waist and hip circumferences and higher amylase, ALT, gGT, uric acid, ferritin, CRP, insulin, and HOMA levels. Total cholesterol and apolipoprotein-A levels were lower and gynoid fat mass was significantly higher. Among subjects with MS, there were higher height and uric acid levels whereas the A/G ratio was higher but borderline significant (p=0.07). Abnormal A/G ratio was moderately useful to index MS when the diagnosis was performed appropriately, not at all if waist circumference was not included in defining MS.
C1 [V. Albanese, Carlina] Sapienza Univ Rome, Dept Internal Med, Anesthesiol & Cardiovasc Sci, I-00161 Rome, Italy.
   [Niglio, Tarcisio; Puddu, Paolo Emilio] Sapienza Univ Rome, Dept Radiol Oncol Anatomo Pathol Sci, I-00161 Rome, Italy.
   [Puddu, Paolo Emilio] Ist Super Sanit Apresidenza, Viale Regina Elena 299, F-00161 Caen, France.
   [Puddu, Paolo Emilio] UNICAEN, EA 4650, Signalisat Electrophysiol & Imagerie Ischemie Rep, F-14000 Caen, France.
   [Puddu, Paolo Emilio] Assoc Cardiac Res, I-00198 Rome, Italy.
   [Puddu, Paolo Emilio] Via Savoia, 78, I-00198 Rome, Italy.
C3 Sapienza University Rome; Sapienza University Rome; Universite de Caen
   Normandie
RP Puddu, PE (corresponding author), Via Savoia, 78, I-00198 Rome, Italy.
EM puddu.pe@gmail.com
RI Puddu, Paolo/G-6180-2012; Zanoni, Cristina/HJA-5257-2022; Niglio,
   Tarcisio/K-2496-2018
OI Martino, Francesco/0000-0002-0368-1994; Puddu, Paolo
   Emilio/0000-0002-6191-7838; Albanese, Carlina V./0000-0002-5676-753X;
   Niglio, Tarcisio/0000-0001-6555-2453
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NR 34
TC 1
Z9 2
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1094-6950
EI 1559-0747
J9 J CLIN DENSITOM
JI J. Clin. Densitom.
PD JAN-MAR
PY 2023
VL 26
IS 1
BP 16
EP 22
DI 10.1016/j.jocd.2022.10.001
EA FEB 2023
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 8X4GN
UT WOS:000931972900001
OA Bronze
DA 2025-06-11
ER

PT J
AU Godoy-Lugo, JA
   Thorwald, MA
   Hui, DY
   Nishiyama, A
   Nakano, D
   Soñanez-Organis, JG
   Ortiz, RM
AF Godoy-Lugo, Jose A.
   Thorwald, Max A.
   Hui, David Y.
   Nishiyama, Akira
   Nakano, Daisuke
   Sonanez-Organis, Jose G.
   Ortiz, Rudy M.
TI Chronic angiotensin receptor activation promotes hepatic triacylglycerol
   accumulation during an acute glucose challenge in
   obese-insulin-resistant OLETF rats
SO ENDOCRINE
LA English
DT Article
DE Angiotensin receptor blocker; ARB; Insulin resistance; Liver steatosis;
   Metabolic syndrome; NAFLD
ID FATTY LIVER-DISEASE; METABOLIC SYNDROME; NONALCOHOLIC STEATOHEPATITIS;
   DIABETES-MELLITUS; OXIDATIVE STRESS; GENE-EXPRESSION; ADIPOSE-TISSUE;
   WHOLE-BODY; HIGH-RISK; TRIGLYCERIDE
AB Purpose Angiotensin receptor blockers (ARBs) can ameliorate metabolic syndrome (MetS)-associated dyslipidemia, hepatic steatosis, and glucose intolerance, suggesting that angiotensin receptor (AT1) over-activation contributes to impaired lipid and glucose metabolism, which is characteristic of MetS. The aim of this study was to evaluate changes in the lipid profile and proteins of fatty acid uptake, triacylglycerol (TAG) synthesis, and beta-oxidation to better understand the links between AT1 overactivation and non-alcoholic fatty liver disease (NAFLD) during MetS. Methods Four groups of 25-week-old-rats were used: (1) untreated LETO, (2) untreated OLETF, (3) OLETF + angiotensin receptor blocker (ARB; 10 mg olmesartan/kg/d x 8 weeks) and (4) OLETF +/- ARB (MINUS; 10 mg olmesartan/kg/d x 4 weeks, then removed until dissection). To investigate the dynamic shifts in metabolism, animals were dissected after an oral glucose challenge (fasting, 3 and 6 h post-glucose). Results Compared to OLETF, plasma total cholesterol and TAG remained unchanged in ARB. However, liver TAG was 55% lesser in ARB than OLETF, and remained lower throughout the challenge. Basal CD36 and ApoB were 28% and 29% lesser, respectively, in ARB than OLETF. PRDX6 abundance in ARB was 45% lesser than OLETF, and it negatively correlated with liver TAG in ARB. Conclusions Chronic blockade of AT1 protects the liver from TAG accumulation during glucose overload. This may be achieved by modulating NEFA uptake and increasing TAG export via ApoB. Our study highlights the contributions of AT1 signaling to impaired hepatic substrate metabolism and the detriments of a high-glucose load and its potential contribution to steatosis during MetS.
C1 [Godoy-Lugo, Jose A.; Thorwald, Max A.; Ortiz, Rudy M.] Univ Calif, Sch Nat Sci, Merced, CA USA.
   [Hui, David Y.] Univ Cincinnati, Pathol & Lab Med, Cincinnati, OH USA.
   [Nishiyama, Akira; Nakano, Daisuke] Kagawa Univ, Sch Med, Dept Pharmacol, Kagawa, Japan.
   [Sonanez-Organis, Jose G.] Univ Sonora, Dept Ciencias Quim & Biol Agr, Navojoa, Sonora, Mexico.
   [Thorwald, Max A.] Univ Southern Calif, Leonard Davis Sch Gerontol, Los Angeles, CA 90007 USA.
C3 University of California System; University of California Merced;
   University System of Ohio; University of Cincinnati; Kagawa University;
   Universidad de Sonora; University of Southern California
RP Godoy-Lugo, JA (corresponding author), Univ Calif, Sch Nat Sci, Merced, CA USA.
EM jgodoy4@ucmerced.edu
RI SONANEZ-ORGANIS, JOSE/L-9583-2019; NAKANO, DAISUKE/JWP-5663-2024
OI Thorwald, Max/0000-0003-0095-5344
FU University of California Mexico-United States (UC MEXUS) [19-194];
   UC-MEXUS Consejo Nacional de Ciencia y Tecnologia (CONACYT) fellowship;
   University of California, Merced; NIH NCMHD [9T37MD001480]
FX Research was partially funded by University of California Mexico-United
   States (UC MEXUS) grant 19-194. J.A.G.L. was supported by the UC-MEXUS
   Consejo Nacional de Ciencia y Tecnologia (CONACYT) fellowship. J.A.G.L.
   and M.A.T. were supported by internal funding from University of
   California, Merced and by NIH NCMHD9T37MD001480.
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NR 96
TC 8
Z9 10
U1 0
U2 1
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1355-008X
EI 1559-0100
J9 ENDOCRINE
JI Endocrine
PD JAN
PY 2022
VL 75
IS 1
BP 92
EP 107
DI 10.1007/s12020-021-02834-7
EA JUL 2021
PG 16
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA YI0VO
UT WOS:000679248900001
PM 34327606
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU de Siqueira, ERF
   Pereira, LB
   Stefano, JT
   Patente, T
   Cavaleiro, AM
   Vasconcelos, LRS
   Carmo, RF
   Pereira, LMMB
   Carrilho, FJ
   Corrêa-Giannella, ML
   Oliveira, CP
AF Forte de Siqueira, Erika Rabelo
   Pereira, Luciano Beltrao
   Stefano, Jose Tadeu
   Patente, Thiago
   Cavaleiro, Ana Mercedes
   Silva Vasconcelos, Luydson Richardson
   Carmo, Rodrigo Feliciano
   Moreira Beltrao Pereira, Leila Maria
   Carrilho, Flair Jose
   Correa-Giannella, Maria Lucia
   Oliveira, Claudia P.
TI Association of a variant in the regulatory region of NADPH oxidase 4
   gene and metabolic syndrome in patients with chronic hepatitis C
SO EUROPEAN JOURNAL OF MEDICAL RESEARCH
LA English
DT Article
DE Hepatitis C; NADPH oxidase 4 polymorphisms; Metabolic syndrome
ID OXIDATIVE STRESS; HEPATOCELLULAR-CARCINOMA; VIRUS-INFECTION; PROTEIN;
   DISEASE; PLASMA; HEALTH; RISK
AB Background: Given the important contribution of the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase system to the generation of reactive oxygen species induced by hepatitis C virus (HCV), we investigated two single nucleotide polymorphisms (SNPs) in the putative regulatory region of the genes encoding NADPH oxidase 4 catalytic subunit (NOX4) and its regulatory subunit p22phox (CYBA) and their relation with metabolic and histological variables in patients with HCV.
   Methods: One hundred seventy eight naive HCV patients (49.3% male; 65% HCV genotype 1) with positive HCV RNA were genotyped using specific primers and fluorescent-labeled probes for SNPs rs3017887 in NOX4 and -675 T -> A in CYBA.
   Results: No association was found between the genotype frequencies of NOX4 and CYBA SNPs and inflammation scores or fibrosis stages in the overall population. The presence of the CA + AA genotypes of the NOX4 SNP was nominally associated with a lower alanine aminotransferase (ALT) concentration in the male population (CA + AA = 72.23 +/- 6.34 U/L versus CC = 100.22 +/- 9.85; mean +/- SEM; P = 0.05). The TT genotype of the CYBA SNP was also nominally associated with a lower ALT concentration in the male population (TT = 84.01 +/- 6.77 U/L versus TA + AA = 109.67 +/- 18.37 U/L; mean +/- SEM; P = 0.047). The minor A-allele of the NOX4 SNP was inversely associated with the frequency of metabolic syndrome (MS) in the male population (odds ratio (OR): 0.15; 95% confidence interval (CI): 0.03 to 0.79; P = 0.025).
   Conclusions: The results suggest that the evaluated NOX4 and CYBA SNPs are not direct genetic determinants of fibrosis in HCV patients, but nevertheless NOX4 rs3017887 SNP could indirectly influence fibrosis susceptibility due to its inverse association with MS in male patients.
C1 [Forte de Siqueira, Erika Rabelo; Pereira, Luciano Beltrao; Stefano, Jose Tadeu] Univ Sao Paulo, Sch Med, Dept Gastroenterol, LIM 07, BR-1246903 Sao Paulo, Brazil.
   [Patente, Thiago; Cavaleiro, Ana Mercedes; Correa-Giannella, Maria Lucia] Univ Sao Paulo, Sch Med, Lab Cellular & Mol Endocrinol, LIM 25, BR-1246903 Sao Paulo, SP, Brazil.
   [Forte de Siqueira, Erika Rabelo; Pereira, Luciano Beltrao; Moreira Beltrao Pereira, Leila Maria] Univ Pernambuco, Sch Med, Dept Gastroenterol, BR-1235 Pernambuco, Brazil.
   [Forte de Siqueira, Erika Rabelo; Pereira, Luciano Beltrao; Silva Vasconcelos, Luydson Richardson; Moreira Beltrao Pereira, Leila Maria] Liver Inst Pernambuco, BR-282 Recife, PE, Brazil.
   [Carmo, Rodrigo Feliciano] Fed Univ Sao Francisco Valley, Coll Pharmaceut Sci, Petrolina, PE, Brazil.
   [Correa-Giannella, Maria Lucia] Univ Sao Paulo, Sch Med, NUCEL NETCEM, Cell & Mol Therapy Ctr, BR-1246903 Sao Paulo, SP, Brazil.
C3 Universidade de Sao Paulo; Universidade de Sao Paulo; Universidade de
   Pernambuco (UPE); Universidade Federal do Vale do Sao Francisco;
   Universidade de Sao Paulo
RP Oliveira, CP (corresponding author), Univ Sao Paulo, Sch Med, Dept Gastroenterol, LIM 07, Av Dr Arnaldo 455,3 Andar 3115, BR-1246903 Sao Paulo, Brazil.
EM cpm@usp.br
RI STEFANO, JOSE TADEU/AGR-5605-2022; Correa-Giannella, Maria
   Lúcia/N-3834-2019; Vasconcelos, Luydson/AAC-4907-2020; Oliveira,
   Claudia/D-1216-2014; Carrilho, Flair/I-3046-2012; Patente,
   Thiago/G-1698-2017; Feliciano do Carmo, Rodrigo/V-9795-2017
OI P Oliveira, Claudia/0000-0002-2848-417X; Silva, Richardson Augusto
   Rosendo da/0000-0001-6290-9365; Patente, Thiago/0000-0001-9333-869X;
   Carrilho, Flair Jose/0000-0002-7682-3105; Feliciano do Carmo,
   Rodrigo/0000-0001-9601-6995; Correa-Giannella, Maria
   Lucia/0000-0003-3655-4446
CR Bedossa P, 1996, HEPATOLOGY, V24, P289, DOI 10.1002/hep.510240201
   Bureau C, 2001, J BIOL CHEM, V276, P23077, DOI 10.1074/jbc.M100698200
   Cave AC, 2006, ANTIOXID REDOX SIGN, V8, P691, DOI 10.1089/ars.2006.8.691
   Choi J, 2014, FREE RADICAL BIO MED, V72, P267, DOI 10.1016/j.freeradbiomed.2014.04.020
   de Mochel NSR, 2010, HEPATOLOGY, V52, P47, DOI 10.1002/hep.23671
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   Guichard C, 2008, BIOCHEM SOC T, V36, P920, DOI 10.1042/BST0360920
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NR 23
TC 5
Z9 6
U1 0
U2 4
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 0949-2321
EI 2047-783X
J9 EUR J MED RES
JI Eur. J. Med. Res.
PD MAR 28
PY 2015
VL 20
AR 45
DI 10.1186/s40001-015-0136-2
PG 6
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA CE8FV
UT WOS:000352078000001
PM 25888935
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU BadioU, S
   Thiebaut, R
   Aurillac-Lavignolle, V
   Dabis, F
   Laporte, F
   Cristol, JP
   Mercie, P
AF Badiou, S.
   Thiebaut, R.
   Aurillac-Lavignolle, V.
   Dabis, F.
   Laporte, F.
   Cristol, J. P.
   Mercie, P.
CA GECSA
TI Association of non-HDL cholesterol with subclinical atherosclerosis in
   HIV-positive patients
SO JOURNAL OF INFECTION
LA English
DT Article
DE apolipoprotein B; atherosclerosis; HIV infection; intima-media
   thickness; metabolic syndrome; non-HDL cholesterol; TG/HDL ratio
ID INTIMA-MEDIA THICKNESS; CORONARY-HEART-DISEASE;
   IMMUNODEFICIENCY-VIRUS-INFECTION; C-REACTIVE PROTEIN; METABOLIC
   SYNDROME; ANTIRETROVIRAL THERAPY; RISK-FACTORS; CARDIOVASCULAR-DISEASE;
   CAROTID ATHEROSCLEROSIS; INSULIN-RESISTANCE
AB Objectives: To assess the relationship between non-classical cardiovascular (CV) risk factors including non-HDL cholesterol (non-HDL-C), apolipoprotein B, triglycerides to HDL ratio, LDL size, inflammation or oxidative stress parameters and carotid intima-media thickness (CIMT), in order to better identify prevention or therapeutic targets. In addition, we studied the relationship between metabolic syndrome (MS) and CIMT.
   Methods: Cross-sectional study including 232 HIV-positive (HIV+) adults (80% treated by combined antiretroviral therapy) extracted from the ANRS CO3 Aquitaine Cohort.
   Results: There was a significant association of higher non-HDL-C (p < 0.01), apolipoprotein B (p < 0.01) levels or TG/HDL ratio (p < 0.05) with higher CIMT when compared the first vs fourth quartile, while there is no association between CIMT and LDL-C (p = 0.09) or LDL size (p = 0.55). In multivariate analysis, only the TG/HDL molar ratio > 1.5 tend toward significance (p = 0.08). MS was observed in only 7.3% of patients with the NCEP-ATP III definition and 11.2% with the IDF criteria. Whatever the used definition, there was a significant association between MS presence and increased CIMT (p < 0.05) in univariate and multivariate model.
   Conclusions: Non-HDL-C, TG/HDL ratio and apolipoprotein B levels, which are closely linked to lipid disorders associated to the MS, appear as stronger predictive markers than LDL-C for screening subclinical atherosclerosis in HIV+ populations. Achieving non-HDL-C target defined by the NCEP-ATP III guidelines appears of great importance to reduce CV complications in HIV+ patients. (c) 2008 The British Infection Society. Published by Elsevier Ltd. All rights reserved.
C1 [Badiou, S.; Cristol, J. P.] Univ Hosp Montpellier, Dept Biochem, F-34295 Montpellier, France.
   [Thiebaut, R.; Aurillac-Lavignolle, V.; Dabis, F.; Mercie, P.] Univ Bordeaux, INSERM U593, ISPED, F-33076 Bordeaux, France.
   [Laporte, F.] Univ Hosp Grenoble, Dept Biochem, F-38000 Grenoble, France.
   [Mercie, P.] Univ Hosp Bordeaux, Dept Internal Med & Infect Dis, F-33076 Bordeaux, France.
   [GECSA] Univ Hosp Bordeaux, CISIH, COREVIH, F-33076 Bordeaux, France.
C3 Universite de Montpellier; CHU de Montpellier; Universite de Bordeaux;
   Institut National de la Sante et de la Recherche Medicale (Inserm); CHU
   Grenoble Alpes; Communaute Universite Grenoble Alpes; Universite
   Grenoble Alpes (UGA); CHU Bordeaux; Universite de Bordeaux; Universite
   de Bordeaux; CHU Bordeaux
RP Cristol, JP (corresponding author), Lapeyronie Univ Hosp, Biochem Lab, 371 Ave Doyen Gaston Giraud, F-34295 Montpellier, France.
EM jp-cristol@chu-montpellier.fr
RI DABIS, FRANCOIS/S-9298-2019; Thiebaut, Rodolphe/T-6803-2019
OI , Jean-Paul Cristol/0000-0001-8563-7278
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NR 58
TC 18
Z9 19
U1 0
U2 0
PU W B SAUNDERS CO LTD
PI LONDON
PA 32 JAMESTOWN RD, LONDON NW1 7BY, ENGLAND
SN 0163-4453
EI 1532-2742
J9 J INFECTION
JI J. Infect.
PD JUL
PY 2008
VL 57
IS 1
BP 47
EP 54
DI 10.1016/j.jinf.2008.05.007
PG 8
WC Infectious Diseases
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases
GA 333VQ
UT WOS:000258181300006
PM 18554723
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Mohamed, HE
   Abdelhady, MA
   Elmaghraby, AM
   Elrashidy, RA
AF Mohamed, Hoda E.
   Abdelhady, Merna A.
   Elmaghraby, Asmaa M.
   Elrashidy, Rania A.
TI Empagliflozin and pirfenidone confer renoprotection through suppression
   of glycogen synthase kinase-3 β and promotion of tubular regeneration in
   rats with induced metabolic syndrome
SO TOXICOLOGY AND APPLIED PHARMACOLOGY
LA English
DT Article
DE Empagliflozin; Glycogen synthasekinase-3 beta; Metabolic syndrome;
   Pirfenidone; CyclinD1
ID SGLT2 INHIBITOR EMPAGLIFLOZIN; OXIDATIVE STRESS; RENAL-FAILURE;
   FRUCTOSE; INFLAMMATION; EXPRESSION; APOPTOSIS; FIBROSIS; PROTECTS;
   INJURY
AB Metabolic syndrome (MetS) is largely coupled with chronic kidney disease (CKD). Glycogen synthase kinase-3 beta (GSK-3 beta) pathway drives tubular injury in animal models of acute kidney injury; but its contribution in CKD is still elusive. This study investigated the effect empagliflozin and/or pirfenidone against MetS-induced kidney dysfunction, and to clarify additional underpinning mechanisms particularly the GSK-3 beta signaling pathway. Adult male rats received 10% w / v fructose in drinking water for 20 weeks to develop MetS, then treated with either drug vehicle, empagliflozin (30 mg/kg/day) and/or pirfenidone (100 mg/kg/day) via oral gavage for subsequent 4 weeks, concurrently with the high dietary fructose. Age-matched rats receiving normal drinking water were used as controls. After 24 weeks, blood and kidneys were harvested for subsequent analyses. Rats with MetS showed signs of kidney dysfunction, structural changes and interstitial fibrosis. Activation of GSK-3 beta, decreased cyclinD1 expression and enhanced apoptotic signaling were found in kidneys of MetS rats. There was abundant alpha-smooth muscle actin ( alpha-SMA) expression along with up-regulation of TGF- beta 1/Smad3 in kidneys of MetS rats. These derangements were almost alleviated by empagliflozin or pirfenidone, with evidence that the combined therapy was more effective than either individual drug. This study emphasizes a novel mechanism underpinning the beneficial effects of empagliflozin and pirfenidone on kidney dysfunction associated with MetS through targeting GSK-3 beta signaling which can mediate the regenerative capacity, anti-apoptotic effects and antifibrotic properties of such drugs. These findings recommend the possibility of using empagliflozin and pirfenidone as promising therapies for management of CKD in patients with MetS.
C1 [Mohamed, Hoda E.; Abdelhady, Merna A.; Elrashidy, Rania A.] Zagazig Univ, Fac Pharm, Biochem Dept, Zagazig 44519, Egypt.
   [Elmaghraby, Asmaa M.] Al Azhar Univ, Fac Med Girls, Histol & Cell Biol Dept, Cairo 11651, Egypt.
C3 Egyptian Knowledge Bank (EKB); Zagazig University; Egyptian Knowledge
   Bank (EKB); Al Azhar University
RP Elrashidy, RA (corresponding author), Zagazig Univ, Fac Pharm, Biochem Dept, Zagazig 44519, Egypt.
EM raelrashidy@zu.edu.eg
RI Elrashidy, Rania/HLW-2856-2023
CR Abd Elmaaboud MA, 2019, J APPL BIOMED, V17, P82, DOI 10.32725/jab.2019.003
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NR 47
TC 1
Z9 1
U1 2
U2 2
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0041-008X
EI 1096-0333
J9 TOXICOL APPL PHARM
JI Toxicol. Appl. Pharmacol.
PD APR
PY 2024
VL 485
AR 116892
DI 10.1016/j.taap.2024.116892
EA MAR 2024
PG 13
WC Pharmacology & Pharmacy; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Toxicology
GA QU2O6
UT WOS:001223318500001
PM 38492675
DA 2025-06-11
ER

PT J
AU Li, XM
   Liu, XJ
   Meng, Q
   Wu, XH
   Bing, X
   Guo, N
   Zhao, XN
   Hou, XZ
   Wang, BW
   Xia, M
   Li, H
AF Li, Xiaoming
   Liu, Xuejian
   Meng, Qiu
   Wu, Xinhao
   Bing, Xin
   Guo, Na
   Zhao, Xuening
   Hou, Xiaozhi
   Wang, Baowei
   Xia, Ming
   Li, Hui
TI Circadian clock disruptions link oxidative stress and systemic
   inflammation to metabolic syndrome in obstructive sleep apnea patients
SO FRONTIERS IN PHYSIOLOGY
LA English
DT Article
DE obstructive sleep apnea; metabolic syndrome; clock genes; insulin
   resistance; flammatory response
ID GENE-EXPRESSION; IDENTIFICATION; INTERLEUKIN-6; MARKERS
AB Objectives: Obstructive sleep apnea (OSA) is an independent risk factor for metabolic syndrome (MetS). Recent studies have indicated that circadian clock genes were dysregulated in OSA. In addition, it is clear that the impairment of circadian clocks drives the progression of MetS. Therefore, we hypothesized that circadian rhythm disruption links OSA with MetS. Methods: A total of 118 participants, who underwent polysomnography (PSG) and were diagnosed as healthy snorers (control, n = 29) or OSA (n = 89) patients based on the apnea-hypopnea index (AHI), were enrolled in the present study. General information, anthropometric data, blood biochemical indicators, clock gene expressions, and levels of oxidative and inflammatory indicators were collected, determined, and compared in all the participants. Results: We found that Brain and muscle aryl hydrocarbon receptor nuclear translocator-like protein 1 (Bmal1) and Differentiated embryo chondrocyte 1 (Dec1) were upregulated, while Period 1 (Per1) was reduced in OSA patients. In addition, these changing trends were closely associated with the hypoxia indicator of AHI and have a significant impact on the presence of MetS components, such as hyperglycemia (Dec1 and Per1, p < 0.05 and 0.001, respectively), hypertension (Bmal1 and Dec1, p < 0.001 and 0.01, respectively), hyperlipidemia (Dec1, p < 0.01), and obesity (Dec1, p < 0.05). Notably, expressions of Dec1 correlated with IR and predicted the presence of MetS in OSA patients. Finally, we also observed that Dec1 expression was interrelated with levels of both oxidative indicators and inflammatory biomarkers (IL-6) in OSA. Conclusion: This study concluded that circadian clock disruptions, especially Dec1, link OSA with MetS in an oxidative and inflammatory-related manner. Circadian clock Dec1 can be used as a specific biomarker (p < 0.001) and therapeutic target in OSA combined with Mets patients.
C1 [Li, Xiaoming; Meng, Qiu; Wu, Xinhao; Bing, Xin; Guo, Na; Zhao, Xuening; Hou, Xiaozhi; Wang, Baowei; Xia, Ming; Li, Hui] Shandong First Med Univ, Dept Otolaryngol, Shandong Prov Hosp, Jinan, Peoples R China.
   [Liu, Xuejian] Shandong Prov Third Hosp, Dept Thyroid & Breast Surg, Jinan, Peoples R China.
C3 Shandong First Medical University & Shandong Academy of Medical Sciences
RP Xia, M; Li, H (corresponding author), Shandong First Med Univ, Dept Otolaryngol, Shandong Prov Hosp, Jinan, Peoples R China.
EM 1977meigui@163.com; xiamingsdu@sohu.com
RI Li, Huihuang/GNM-7727-2022; liu, xuejian/ABB-4120-2021; Xia,
   Ming/I-3645-2019
FU Natural Science Foundationof Shandong Province [ZR2020QH155,
   ZR2021MH189]
FX This work was supported by the Natural Science Foundationof Shandong
   Province (Nos. ZR2020QH155 and ZR2021MH189).
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NR 56
TC 21
Z9 21
U1 2
U2 11
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1664-042X
J9 FRONT PHYSIOL
JI Front. Physiol.
PD AUG 29
PY 2022
VL 13
AR 932596
DI 10.3389/fphys.2022.932596
PG 13
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA 4N5DQ
UT WOS:000854040000001
PM 36105285
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Tran, HQ
   Bretin, A
   Adeshirlarijaney, A
   San Yeoh, B
   Vijay-Kumar, M
   Zou, J
   Denning, TL
   Chassaing, B
   Gewirtz, AT
AF Tran, Hao Q.
   Bretin, Alexis
   Adeshirlarijaney, Aneseh
   San Yeoh, Beng
   Vijay-Kumar, Matam
   Zou, Jun
   Denning, Timothy L.
   Chassaing, Benoit
   Gewirtz, Andrew T.
TI "Western Diet"-Induced Adipose Inflammation Requires a Complex Gut
   Microbiota
SO CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
LA English
DT Article
DE Metabolic Syndrome; Microbiota; Germ-Free; Antibiotics; Altered
   Schaedler Flora; High-Fat Diet; MyD88
ID INTESTINAL MICROBIOTA; INDUCED OBESITY; PPAR-GAMMA; GERM-FREE; FAT;
   MICE; EOSINOPHILS; ACTIVATION
AB BACKGROUND & AIMS: Consumption of a low-fiber, high-fat, Western-style diet (WSD) induces adiposity and adipose inflammation characterized by increases in the M1:M2 macrophage ratio and proinflammatory cytokine expression, both of which contribute to WSD-induced metabolic syndrome. WSD-induced adipose inflammation might result from endoplasmic reticulum stress in lipid-overloaded adipocytes and/or dissemination of gut bacterial products, resulting in activation of innate immune signaling. Hence, we aimed to investigate the role of the gut microbiota, and its detection by innate immune signaling pathways, in WSD-induced adipose inflammation.
   METHODS: Mice were fed grain-based chow or a WSD for 8 weeks, assessed metabolically, and intestinal and adipose tissue were analyzed by flow cytometry and quantitative reverse transcription polymerase chain reaction. Microbiota was ablated via antibiotics and use of gnotobiotic mice that completely lacked microbiota (germ-free mice) or had a low-complexity microbiota (altered Schaedler flora). Innate immune signaling was ablated by genetic deletion of Toll-like receptor signaling adaptor myeloid differentiation primary response 88.
   RESULTS: Ablation of microbiota via antibiotic, germ-free, or altered Schaedler flora approaches did not significantly impact WSD-induced adiposity, yet dramatically reduced WSD-induced adipose inflammation as assessed by macrophage populations and cytokine expression. Microbiota ablation also prevented colonic neutrophil and CD103(-) dendritic cell infiltration. Such reduced indices of inflammation correlated with protection against WSD-induced dysglycemia, hypercholesterolemia, and liver dysfunction. Genetic deletion of myeloid differentiation primary response 88 also prevented WSD-induced adipose inflammation.
   CONCLUSIONS: These results indicate that adipose inflammation, and some aspects of metabolic syndrome, are not purely a consequence of diet-induced adiposity per se but, rather, may require disturbance of intestine-microbiota interactions and subsequent activation of innate immunity.
C1 [Tran, Hao Q.; Bretin, Alexis; Adeshirlarijaney, Aneseh; Zou, Jun; Denning, Timothy L.; Chassaing, Benoit; Gewirtz, Andrew T.] Georgia State Univ, Inst Biomed Sci, Atlanta, GA 30303 USA.
   [Chassaing, Benoit] Georgia State Univ, Neurosci Inst, Atlanta, GA 30303 USA.
   [San Yeoh, Beng] Penn State Univ, Grad Program Immunol & Infect Dis, Philadelphia, PA USA.
   [Vijay-Kumar, Matam] Univ Toledo, Dept Physiol & Pharmacol, Coll Med & Life Sci, 2801 W Bancroft St, Toledo, OH 43606 USA.
C3 University System of Georgia; Georgia State University; University
   System of Georgia; Georgia State University; Pennsylvania Commonwealth
   System of Higher Education (PCSHE); Pennsylvania State University;
   University System of Ohio; University of Toledo
RP Gewirtz, AT (corresponding author), Inst Biomed Sci, 100 Piedmont Ave SE,POB 5035, Atlanta, GA 30303 USA.
EM agewirtz@gsu.edu
RI Denning, Timothy/F-2271-2011; Gewirtz, Andrew/HCH-2932-2022; Chassaing,
   Benoit/R-3819-2017; ZOU, JUN/AAD-3904-2019
FU National Institute of Diabetes and Digestive and Kidney Diseases
   [DK099071, DK083890]; Career Development Award from the Crohn's and
   Colitis Foundation of America; National Institute of Diabetes and
   Digestive and Kidney Diseases [P30DK020572] Funding Source: NIH RePORTER
FX This work was supported by National Institute of Diabetes and Digestive
   and Kidney Diseases grants DK099071 and DK083890 (A.T.G.), and by a
   Career Development Award from the Crohn's and Colitis Foundation of
   America (B.C.).
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NR 36
TC 45
Z9 47
U1 2
U2 24
PU ELSEVIER INC
PI SAN DIEGO
PA 525 B STREET, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 2352-345X
J9 CELL MOL GASTROENTER
JI Cell. Mol. Gastroenterol. Hepatol.
PY 2020
VL 9
IS 2
BP 313
EP 333
DI 10.1016/j.jcmgh.2019.09.009
PG 21
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA KI4CP
UT WOS:000511296900007
PM 31593782
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Aksoy, F
   Guler, S
   Kahraman, F
   Kuyumcu, MS
   Bagci, A
   Bas, HA
   Uysal, D
   Varol, E
AF Aksoy, Fatih
   Guler, Serdar
   Kahraman, Fatih
   Kuyumcu, Mevlut Serdar
   Bagci, Ali
   Bas, Hasan Aydin
   Uysal, Dincer
   Varol, Ercan
TI The Relationship Between Mitral Annular Calcification, Metabolic
   Syndrome and Thromboembolic Risk
SO BRAZILIAN JOURNAL OF CARDIOVASCULAR SURGERY
LA English
DT Article
DE Atrial Fibrilation; Stroke; Metabolic Syndrome; Coronary Artery Disease;
   Brain Ischemia; Thromboembolism; Hypertension
ID ATRIAL-FIBRILLATION; OXIDATIVE STRESS; ATHEROSCLEROSIS; PROGRESSION;
   MANAGEMENT; COMMUNITY; HEART
AB Introduction: Metabolic syndrome (MetS) is defined as an association between diabetes, hypertension, obesity and dyslipidemia and an increased risk of cardiovascular disease. Mitral annular calcification (MAC) is associated with several cardiovascular disorders, including coronary artery disease, atrial fibrillation (AF), heart failure, ischemic stroke and increased mortality. The CHA(2)DS(2)-VASc score is used to estimate thromboembolic risk in AF. However, the association among MAC, MetS and thromboembolic risk is unknown and was evaluated in the current study.
   Methods: The study group consisted of 94 patients with MAC and 86 patients with MetS. Patients were divided into two groups: those with and those without MAC.
   Results: Patients with MAC had a higher MetS rate (P<0.001). In patients with MAC, the CHA(2)DS(2)-VASc scores and the rate of cerebrovascular accident and AF were significantly higher compared to those without MAC (P<0.001, for both parameters). The results of the multivariate regression analysis showed that history of smoking, presence of MetS and high CHA(2)DS(2)-VASc scores were associated with the development of MAC. ROC curve analyses showed that CHA(2)DS(2)-VASc scores were signi.cant predictors for MAC (C-statistic: 0.78; 95% CI: 0.706-0.855, P<0.001). Correlation analysis indicated that MAC was positively correlated with the presence of MetS and CHA(2)DS(2)-VASc score (P=0.001, r=0.264; P<0.001, r=0.490).
   Conclusion: We have shown that CHA(2)DS(2)-VASc score and presence of MetS rates were significantly higher in patients with MAC compared without MAC. Presence of MAC was correlated with CHA(2)DS(2)-VASc score, presence of MetS, AF and left atrial diameter and negatively correlated with left ventricular ejection fraction.
C1 [Aksoy, Fatih; Guler, Serdar; Kahraman, Fatih; Kuyumcu, Mevlut Serdar; Bagci, Ali; Bas, Hasan Aydin; Varol, Ercan] Suleyman Demirel Univ, Med Sch, Dept Cardiol, TR-32260 Isparta, Turkey.
   [Uysal, Dincer] Suleyman Demirel Univ, Med Sch, Dept Cardiovasc Surg, Isparta, Turkey.
C3 Suleyman Demirel University; Suleyman Demirel University
RP Aksoy, F (corresponding author), Suleyman Demirel Univ, Med Sch, Dept Cardiol, TR-32260 Isparta, Turkey.
EM dr.aksoy@hotmail.com
RI Kahraman, Fatih/AEI-5298-2022; Aksoy, Fatih/ABE-2277-2020
OI Aksoy, Fatih/0000-0001-6749-4293; Technologies,
   BioSig/0000-0001-8277-164X
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NR 25
TC 9
Z9 9
U1 0
U2 4
PU SOC BRASIL CIRURGIA CARDIOVASC
PI SAO PAULO SP
PA RUA AFONSO CELSO, 1178, SAO PAULO SP, 04119-061, BRAZIL
SN 0102-7638
EI 1678-9741
J9 BRAZ J CARDIOVA SURG
JI Braz. J. Cardiovasc. Surg.
PY 2019
VL 34
IS 5
BP 535
EP 541
DI 10.21470/1678-9741-2019-0062
PG 7
WC Cardiac & Cardiovascular Systems; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Surgery
GA JG1YI
UT WOS:000491873000007
PM 31719007
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Malinska, H
   Hüttl, M
   Oliyarnyk, O
   Bratova, M
   Kazdova, L
AF Malinska, Hana
   Huettl, Martina
   Oliyarnyk, Olena
   Bratova, Miriam
   Kazdova, Ludmila
TI Conjugated linoleic acid reduces visceral and ectopic lipid accumulation
   and insulin resistance in chronic severe hypertriacylglycerolemia
SO NUTRITION
LA English
DT Article
DE Conjugated linoleic acid; Insulin sensitivity; Fatty acid composition;
   Oxidative stress; Metabolic syndrome; Hypertriacylglycerolmic rats
ID ADIPOSE-TISSUE; FATTY-ACIDS; OBESE; METAANALYSIS; ADIPONECTIN; RAT;
   METABOLISM; EFFICACY; DISEASE; MODEL
AB Objective: The metabolic health effects of conjugated linoleic acid (CIA), which is one of the principal polyunsaturated fatty acids, are controversial and still not fully accepted. The aim of this study was to examine the effects of CIA on adiposity, ectopic lipid accumulation, and insulin-resistant states in a metabolic syndrome model of non-obese hereditary rats with hypertriacylglycerolmia (HHTg).
   Methods: Groups of adult male HHTg rats were fed a high-carbohydrate diet (70% sucrose) with a 2% mixture of CIA isomers, or with the same amount of sunflower oil (control group) for 2 mo.
   Results: CIA supplementation decreased body weight gain (P < 0.05) and visceral adipose tissue weight (P < 0.01), and distinctively reduced serum triacylglycerols (P < 0.01) and triacylglycerol accumulation in the liver, heart, muscle, and aorta. CIA-treated rats exhibited increased insulin sensitivity in the adipose (P < 0.01), a higher release of fatty acids (P < 0.001), and increased adiponectin secretion (P < 0.01),In the skeletal muscle, CIA supplementation was associated with increased glucose oxidation (P < 0.01) and an elevated anti-inflammatory index (P < 0.05), according to phospholipid fatty acid composition. In the liver, CIA reduced the oxidized form of glutathione and elevated the activity of glutathione-dependent antioxidant enzymes.
   Conclusion: Results suggest that CIA supplementation may protect against HHTg-induced dyslipidemia, ectopic lipid deposition, and insulin resistance. Increased glucose oxidation in the skeletal muscle as well as adiponectin secretion may play a role in the mechanism of the CIA action. Results suggest that CIA could reduce the negative consequences of HHTg and metabolic syndrome. (C) 2015 Elsevier Inc. All rights reserved.
C1 [Malinska, Hana; Huettl, Martina; Oliyarnyk, Olena; Bratova, Miriam; Kazdova, Ludmila] Inst Clin & Expt Med, Ctr Med Expt, Prague, Czech Republic.
C3 Institute for Clinical & Experimental Medicine (IKEM)
RP Malinska, H (corresponding author), Inst Clin & Expt Med, Ctr Med Expt, Prague, Czech Republic.
EM haml@ikem.cz
RI Oliyarnyk, Olena/Q-6380-2019
OI Oliyarnyk, Olena/0000-0002-4912-6187
FU Ministry of Health of the Czech Republic
FX This work was supported by the Ministry of Health of the Czech Republic.
   This work is a conceptual development by a research organisation
   (Institute for Clinical and Experimental Medicine - IKEM, IN 00023001).
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NR 39
TC 35
Z9 38
U1 0
U2 17
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0899-9007
EI 1873-1244
J9 NUTRITION
JI Nutrition
PD JUL-AUG
PY 2015
VL 31
IS 7-8
BP 1045
EP 1051
DI 10.1016/j.nut.2015.03.011
PG 7
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA CL5KE
UT WOS:000356998000023
PM 26059381
DA 2025-06-11
ER

PT J
AU Mohanty, S
   Mohanty, P
   Di Biase, L
   Bai, R
   Trivedi, C
   Santangeli, P
   Santoro, F
   Hongo, R
   Hao, S
   Beheiry, S
   Burkhardt, D
   Gallinghouse, JG
   Horton, R
   Sanchez, JE
   Bailey, S
   Hranitzky, PM
   Zagrodzky, J
   Natale, A
AF Mohanty, Sanghamitra
   Mohanty, Prasant
   Di Biase, Luigi
   Bai, Rong
   Trivedi, Chintan
   Santangeli, Pasquale
   Santoro, Francesco
   Hongo, Richard
   Hao, Steven
   Beheiry, Salwa
   Burkhardt, David
   Gallinghouse, Joseph G.
   Horton, Rodney
   Sanchez, Javier E.
   Bailey, Shane
   Hranitzky, Patrick M.
   Zagrodzky, Jason
   Natale, Andrea
TI Long-Term Outcome of Catheter Ablation in Atrial Fibrillation Patients
   with Coexistent Metabolic Syndrome and Obstructive Sleep Apnea: Impact
   of Repeat Procedures versus Lifestyle Changes
SO JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
LA English
DT Article
DE atrial fibrillation; catheter ablation; recurrence; lifestyle
   modifications; metabolic syndrome; obstructive sleep apnea
ID PHYSICAL-ACTIVITY; OXIDATIVE STRESS; PULMONARY VEIN; RISK; RECURRENCE;
   INTERVENTION; INFLAMMATION; EFFICACY; STROKE; ADULTS
AB Ablation Outcome in AF with Concurrent MS and OSA. Introduction: Metabolic syndrome (MS) and obstructive sleep apnea (OSA) are well-known independent risk factors for atrial fibrillation (AF) recurrence. This study evaluated ablation outcome in AF patients with coexistent MS and OSA and influence of lifestyle modifications (LSM) on arrhythmia recurrence.
   Methods and Results: We included 1,257 AF patients undergoing first catheter ablation (30% paroxysmal AF). Patients having MS + OSA were classified into Group 1 (n = 126; 64 +/- 8 years; 76% male). Group 2 (n = 1,131; 62 +/- 11 years; 72% male) included those with either MS (n = 431) or OSA (n = 112; no CPAP users) or neither of these comorbidities (n = 588). Patients experiencing recurrence after first procedure were divided into 2 subgroups; those having sporadic events (frequency < 2 months) remained on previously ineffective antiarrhythmic drugs (AAD) and aggressive LSM, while those with persistent arrhythmia (incessant or >= 2 months) underwent repeat ablation. After 34 +/- 8 months of first procedure, 66 (52%) in Group 1 and 386 (34%) in Group 2 had recurrence (P < 0.001). Recurrence rate in only-MS, only-OSA, and without MS/OSA groups were 40%, 38%, and 29%, respectively. Patients with MS + OSA experienced substantially higher recurrence compared to those with lone MS or OSA (52% vs. 40% vs. 38%; P = 0.036). Of the 452 patients having recurrence, 250 underwent redo-ablation and 194 remained on AAD and LSM. At 20 +/- 6 months, 76% of the redo group remained arrhythmia-free off AAD whereas 74% of the LSM group were free from recurrence (P = 0.71), 33% of which were off AAD.
   Conclusions: MS and OSA have additive negative effect on arrhythmia recurrence following single procedure. Repeat ablation or compliant LSM increase freedom from recurrent AF.
C1 [Mohanty, Sanghamitra; Mohanty, Prasant; Di Biase, Luigi; Bai, Rong; Trivedi, Chintan; Santangeli, Pasquale; Burkhardt, David; Gallinghouse, Joseph G.; Horton, Rodney; Sanchez, Javier E.; Bailey, Shane; Hranitzky, Patrick M.; Zagrodzky, Jason; Natale, Andrea] St Davids Med Ctr, Texas Cardiac Arrhythmia Inst, Austin, TX USA.
   [Mohanty, Sanghamitra] Univ Texas Austin, Coll Nat Sci, Austin, TX 78712 USA.
   [Di Biase, Luigi; Natale, Andrea] Univ Texas Austin, Dept Biomed Engn, Austin, TX 78712 USA.
   [Di Biase, Luigi; Santangeli, Pasquale; Santoro, Francesco] Univ Foggia, Dept Cardiol, Foggia, Italy.
   [Di Biase, Luigi] Montefiore Hosp, Albert Einstein Coll Med, New York, NY USA.
   [Bai, Rong] Capital Med Univ, Beijing Anzhen Hosp, Beijing, Peoples R China.
   [Hongo, Richard; Hao, Steven; Beheiry, Salwa; Natale, Andrea] Calif Pacific Med Ctr, San Francisco, CA USA.
   [Natale, Andrea] Stanford Univ, Div Cardiol, Palo Alto, CA 94304 USA.
   [Natale, Andrea] Scripps Clin, San Diego, CA USA.
   [Natale, Andrea] Case Western Reserve Univ, Cleveland, OH 44106 USA.
C3 Saint David's Medical Center; University of Texas System; University of
   Texas Austin; University of Texas System; University of Texas Austin;
   University of Foggia; Yeshiva University; Capital Medical University;
   California Pacific Medical Center; Stanford University; Scripps Research
   Institute; University System of Ohio; Case Western Reserve University
RP Natale, A (corresponding author), 3000 N I-35,Suite 720, Austin, TX 78705 USA.
EM dr.natale@gmail.com
RI Santoro, Francesco/AAK-7009-2021; Mohanty, Sanghamitra/D-1122-2015
OI Santangeli, Pasquale/0000-0002-0023-9666; Santoro,
   Francesco/0000-0001-9909-6513; Di Biase, Luigi/0000-0001-6508-4047;
   Mohanty, Sanghamitra/0000-0001-6601-944X
FU Boston Scientific; Biosense Webster; Janssen; St. Jude Medical;
   Medtronic; Biotronik
FX Dr. Di Biase is a consultant for Hansen Medical, St. Jude Medical, and
   Biosense Webster. Dr. Hao reports serving as an advisory board member
   for Biosense Webster. Dr. Burkhardt reports compensation for serving on
   a speaker's bureau for Biosense Webster and Boehringer Ingelheim. Dr.
   Natale received consulting fees/honoraria from Boston Scientific,
   Biosense Webster, Janssen, St. Jude Medical, Medtronic, and Biotronik.
   Other authors: No disclosures.
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NR 38
TC 36
Z9 36
U1 0
U2 4
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1045-3873
EI 1540-8167
J9 J CARDIOVASC ELECTR
JI J. Cardiovasc. Electrophysiol.
PD SEP
PY 2014
VL 25
IS 9
BP 930
EP 938
DI 10.1111/jce.12468
PG 9
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA AP1IE
UT WOS:000341821200004
PM 24903158
DA 2025-06-11
ER

PT J
AU Zawieja, SD
   Wang, W
   Wu, X
   Nepiyushchikh, ZV
   Zawieja, DC
   Muthuchamy, M
AF Zawieja, Scott D.
   Wang, Wei
   Wu, Xin
   Nepiyushchikh, Zhanna V.
   Zawieja, David C.
   Muthuchamy, Mariappan
TI Impairments in the intrinsic contractility of mesenteric collecting
   lymphatics in a rat model of metabolic syndrome
SO AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
LA English
DT Article
DE chronotropic effect; lymphatic muscle; calcium sensitivity
ID INSULIN-RESISTANCE; ENDOTHELIAL-CELLS; OXIDATIVE STRESS; ADIPOSE-TISSUE;
   CARDIOVASCULAR-DISEASE; ANIMAL-MODEL; RECEPTOR 4; INFLAMMATION;
   ENDOTOXIN; CHYLOMICRONS
AB Zawieja SD, Wang W, Wu X, Nepiyushchikh ZV, Zawieja DC, Muthuchamy M. Impairments in the intrinsic contractility of mesenteric collecting lymphatics in a rat model of metabolic syndrome. Am J Physiol Heart Circ Physiol 302: H643-H653, 2012. First published December 9, 2011; doi:10.1152/ajpheart.00606.2011.-Numerous studies on metabolic syndrome (MetSyn), a cluster of metabolic abnormalities, have demonstrated its profound impact on cardiovascular and blood microvascular health; however, the effects of MetSyn on lymphatic function are not well understood. We hypothesized that MetSyn would modulate lymphatic muscle activity and alter muscularized lymphatic function similar to the impairment of blood vessel function associated with MetSyn, particularly given the direct proximity of the lymphatics to the chronically inflamed adipose depots. To test this hypothesis, rats were placed on a high-fructose diet (60%) for 7 wk, and their progression to MetSyn was assessed through serum insulin and triglyceride levels in addition to the expression of metabolic and inflammatory genes in the liver. Mesenteric lymphatic vessels were isolated and subjected to different transmural pressures while lymphatic pumping and contractile parameters were evaluated. Lymphatics from MetSyn rats had significant negative chronotropic effects at all pressures that effectively reduced the intrinsic flow-generating capacity of these vessels by similar to 50%. Furthermore, lymphatics were remodeled to a significantly smaller diameter in the animals with MetSyn. Wire myograph experiments demonstrated that permeabilized lymphatics from the MetSyn group exhibited a significant decrease in force generation and were less sensitive to Ca2+, although there were no significant changes in lymphatic muscle cell coverage or morphology. Thus, our data provide the first evidence that MetSyn induces a remodeling of collecting lymphatics, thereby effectively reducing their potential load capabilities and impairing the intrinsic contractility required for proper lymph flow.
C1 [Zawieja, Scott D.; Wang, Wei; Wu, Xin; Nepiyushchikh, Zhanna V.; Zawieja, David C.; Muthuchamy, Mariappan] Texas A&M Hlth Sci Ctr Coll Med, Dept Syst Biol & Translat Med, College Stn, TX 77843 USA.
C3 Texas A&M University System; Texas A&M University College Station; Texas
   A&M Health Science Center
RP Muthuchamy, M (corresponding author), Texas A&M Hlth Sci Ctr Coll Med, Dept Syst Biol & Translat Med, 336 Reynolds Med Bldg, College Stn, TX 77843 USA.
EM marim@tamu.edu
OI wu, xin/0000-0002-5005-6358; Zawieja, David/0000-0002-2644-6524
FU National Heart, Lung, and Blood Institute [HL-80526, KO2-HL-86650,
   HL-070308, HL-096552]; Lymphatic Research Foundation
FX This work was supported by National Heart, Lung, and Blood Institute
   Grants HL-80526 and KO2-HL-86650 (to M. Muthuchamy) and HL-070308 and
   HL-096552 (to D. C. Zawieja). Z. V. Nepiyushchikh is a recipient of a
   postdoctoral research fellowship from the Lymphatic Research Foundation.
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NR 76
TC 75
Z9 87
U1 0
U2 2
PU AMER PHYSIOLOGICAL SOC
PI Rockville
PA 6120 Executive Blvd, Suite 600, Rockville, MD, UNITED STATES
SN 0363-6135
EI 1522-1539
J9 AM J PHYSIOL-HEART C
JI Am. J. Physiol.-Heart Circul. Physiol.
PD FEB
PY 2012
VL 302
IS 3
BP H643
EP H653
DI 10.1152/ajpheart.00606.2011
PG 11
WC Cardiac & Cardiovascular Systems; Physiology; Peripheral Vascular
   Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Physiology
GA 896YE
UT WOS:000300606500016
PM 22159997
OA Green Published
DA 2025-06-11
ER

PT J
AU Fang, YH
   Nicol, L
   Harouki, N
   Monteil, C
   Wecker, D
   Debunne, M
   Bauer, F
   Lallemand, F
   Richard, V
   Thuillez, C
   Mulder, P
AF Fang, Yuehua
   Nicol, Lionel
   Harouki, Najah
   Monteil, Christelle
   Wecker, Didier
   Debunne, Manuelle
   Bauer, Fabrice
   Lallemand, Francoise
   Richard, Vincent
   Thuillez, Christian
   Mulder, Paul
TI Improvement of left ventricular diastolic function induced by β-blockade
   A comparison between nebivolol and metoprolol
SO JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
LA English
DT Article
DE Nebivolol; Metoprolol; Diastolic heart failure; Metabolic syndrome;
   Zucker
ID OBESE ZUCKER RATS; NITRIC-OXIDE SYNTHASE; CHRONIC HEART-FAILURE; FAILING
   DIABETIC HEART; METABOLIC SYNDROME; OXIDATIVE STRESS; NADPH OXIDASE;
   ENDOTHELIAL DYSFUNCTION; MYOCARDIAL PERFUSION; PRESSURE-OVERLOAD
AB Objectives: Enhanced adrenergic drive is involved in the development of left ventricular (LV) diastolic dysfunction observed in metabolic syndrome (MS). Thus, beta-blockers might improve LV dysfunction observed in MS, but whether this occurs is unknown.
   Methods: We assessed in Zucker fa/fa rats the effects of short- (5 days) and long-term (90 days) metoprolol ('pure' beta-blockade; 80 mg/kg/day) or nebivolol (beta-blocker with vasodilating properties: 5 mg/kg/day) treatment on LV hemodynamics and remodeling, as well as the long-term effects on coronary and peripheral endothelial dysfunction.
   Results: At identical degree of beta(1)-receptor blockade, metoprolol and nebivolol decreased heart rate to the same extent and preserved cardiac output via increased stroke volume. None of the beta-blockers, either after long- or short-term administration, modified LV end-systolic pressure-volume relation. Both beta-blockers reduced, after long-term administration, LV end-diastolic pressure, Tau and end-diastolic pressure-volume relation, and this was associated with reduced LV collagen density, but not heart weight. Similar hemodynamic effects were also observed after short-term nebivolol, but not short-term metoprolol. These short-term effects of nebivolol were abolished by NO synthase inhibition. At the vascular level, nebivolol, and to a lesser extend metoprolol, improved NO dependent coronary vasorelaxation, which was abolished by NO synthase inhibition.
   Conclusions: In a model of MS, the beta-blockers metoprolol and nebivolol improve to the same extent LV hemodynamics, remodeling and diastolic function, but nebivolol prevent more markedly endothelium dependent vasorelaxation involving a more marked enhancement of NO bio-availability. (C) 2011 Elsevier Ltd. All rights reserved.
C1 [Fang, Yuehua; Nicol, Lionel; Harouki, Najah; Monteil, Christelle; Debunne, Manuelle; Bauer, Fabrice; Lallemand, Francoise; Richard, Vincent; Thuillez, Christian; Mulder, Paul] INSERM U644, Inst Federatif Rech Multidisciplinaires Peptides, UFR Med & Pharm, F-76000 Rouen, France.
   [Fang, Yuehua] Jiao Tong Univ, Dept Cardiol, Shanghai Ruijin Hosp, Shanghai 200030, Peoples R China.
   [Wecker, Didier] Bruker Biospin MRI GMBH, Ettlingen, Germany.
C3 Institut National de la Sante et de la Recherche Medicale (Inserm);
   Universite de Rouen Normandie; Shanghai Jiao Tong University; Bruker
   Corporation; Bruker BioSpin GmbH
RP Mulder, P (corresponding author), INSERM U644, Inst Federatif Rech Multidisciplinaires Peptides, UFR Med & Pharm, 22 Bd Gambetta, F-76000 Rouen, France.
EM paul.mulder@univ-rouen.fr
RI BAUER, Fabrice/HMP-7663-2023; Monteil, Christelle/ABF-3312-2022;
   Richard, Vincent/B-1059-2014
OI Mulder, Paul/0000-0002-5936-5704; Monteil,
   Christelle/0000-0002-4981-0800; Richard, Vincent/0000-0003-0590-0158
FU Menarini France
FX This work was supported by a research grant from Menarini France.
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NR 56
TC 24
Z9 26
U1 0
U2 3
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 0022-2828
EI 1095-8584
J9 J MOL CELL CARDIOL
JI J. Mol. Cell. Cardiol.
PD AUG
PY 2011
VL 51
IS 2
BP 168
EP 176
DI 10.1016/j.yjmcc.2011.05.012
PG 9
WC Cardiac & Cardiovascular Systems; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Cell Biology
GA 790HG
UT WOS:000292578500004
PM 21640121
DA 2025-06-11
ER

PT J
AU Ryu, S
   Chang, Y
   Woo, HY
   Yoo, SH
   Choi, NK
   Lee, WY
   Kim, I
   Song, J
AF Ryu, Seungho
   Chang, Yoosoo
   Woo, Hee-Yeon
   Yoo, Sang-Ho
   Choi, Nam-Kyong
   Lee, Won-Young
   Kim, Inah
   Song, Jaechul
TI Longitudinal increase in γ-glutamyltransferase within the reference
   interval predicts metabolic syndrome in middle-aged Korean men
SO METABOLISM-CLINICAL AND EXPERIMENTAL
LA English
DT Article
ID ALANINE AMINOTRANSFERASE; CARDIOVASCULAR-DISEASE; INSULIN-RESISTANCE;
   DIABETES-MELLITUS; OXIDATIVE STRESS; RISK DEVELOPMENT; FATTY LIVER;
   ASSOCIATION; MORTALITY; GLUTAMYLTRANSFERASE
AB In the absence of existing research, we examined the association between longitudinal changes in serum gamma-glutamyltransferase (GOT) levels and the risk for metabolic syndrome (MetS). A MetS-free cohort of 9148 healthy male workers, who had participated in a health checkup program in 2002, was followed until September 2007. Metabolic syndrome was defined according to the modified National Cholesterol Education Program, using body mass index instead of waist circumference. Standard Cox proportional hazards and time-dependent Cox models were performed. During 37 663.4 person-years of follow-up, 1056 men developed MetS. The risk of incident MetS increased across the baseline GOT quartiles, even after further updating GGT values during the follow-up. A longitudinal increase in GOT as a time-dependent variable as well as a non-time-dependent variable was significantly related to MetS after adjusting for age plus the elapsed time from visit 1 to visit 2, baseline MetS traits, uric acid, regular exercise, alcohol consumption, and smoking. Even within the GGT reference interval (<40 U/L), the fourth quartile of GGT change predicted the development of MetS (adjusted hazard risk, 1.61; 95% confidence interval, 1.26-2.07). Furthermore, these associations were consistently observed within the subgroups those with body mass index less than 23 kg/m(2), C-reactive protein less than 3.0 mg/L, homeostasis model assessment of insulin resistance less than 2.04, alcohol intake not exceeding 20 g/d, alanine aminotransferase less than 35 U/L, an absence of ultrasonographically detected fatty liver, and an absence of any MetS traits. A longitudinal increase in the GOT level, even within the GOT reference interval, may be an independent predictor for MetS, regardless of the baseline GGT. (C) 2010 Elsevier Inc. All rights reserved.
C1 [Song, Jaechul] Hanyang Univ, Coll Med, Dept Occupat & Environm Med, Seoul 133791, South Korea.
   [Ryu, Seungho] Sungkyunkwan Univ, Kangbuk Samsung Hosp, Dept Occupat Med, Sch Med, Seoul 110746, South Korea.
   [Chang, Yoosoo] Sungkyunkwan Univ, Kangbuk Samsung Hosp, Hlth Screening Ctr, Sch Med, Seoul 110746, South Korea.
   [Woo, Hee-Yeon] Sungkyunkwan Univ, Kangbuk Samsung Hosp, Dept Lab Med, Sch Med, Seoul 110746, South Korea.
   [Lee, Won-Young] Sungkyunkwan Univ, Kangbuk Samsung Hosp, Dept Internal Med, Sch Med, Seoul 110746, South Korea.
   [Yoo, Sang-Ho] Hallym Univ, Sch Med, Dept Family Med, Sacred Heart Hosp, Anyang 431070, South Korea.
   [Choi, Nam-Kyong] Seoul Natl Univ, Coll Med, Med Res Ctr, Dept Prevent Med, Seoul 110799, South Korea.
   [Kim, Inah] Eulji Univ, Eulji Univ Hosp, Sch Med, Dept Occupat & Environm Med, Taejon 302799, South Korea.
C3 Hanyang University; Sungkyunkwan University (SKKU); Samsung Medical
   Center; Sungkyunkwan University (SKKU); Samsung Medical Center;
   Sungkyunkwan University (SKKU); Samsung Medical Center; Sungkyunkwan
   University (SKKU); Samsung Medical Center; Hallym University; Seoul
   National University (SNU); Eulji University; Eulji University Hospital
RP Song, J (corresponding author), Hanyang Univ, Coll Med, Dept Occupat & Environm Med, Seoul 133791, South Korea.
EM jsong@hanyang.ac.kr
RI ; LEE, WON-YOUNG/C-7249-2018
OI Ryu, Seungho/0000-0002-3927-8646; Choi, Nam-Kyong/0000-0003-1153-9928;
   Chang, Yoosoo/0000-0002-6945-9050; LEE, WON-YOUNG/0000-0002-1082-7592
FU Hanyang University [HY-20064]
FX Grant support: This work was supported by the research fund of Hanyang
   University (HY-20064).
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U1 0
U2 9
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0026-0495
EI 1532-8600
J9 METABOLISM
JI Metab.-Clin. Exp.
PD MAY
PY 2010
VL 59
IS 5
BP 683
EP 689
DI 10.1016/j.metabol.2009.08.024
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 588VX
UT WOS:000277103700011
PM 19922966
DA 2025-06-11
ER

PT J
AU Mackonochie, M
   Rodriguez-Mateos, A
   Mills, S
   Rolfe, V
AF Mackonochie, Marion
   Rodriguez-Mateos, Ana
   Mills, Simon
   Rolfe, Vivien
TI A Scoping Review of the Clinical Evidence for the Health Benefits of
   Culinary Doses of Herbs and Spices for the Prevention and Treatment of
   Metabolic Syndrome
SO NUTRIENTS
LA English
DT Review
DE diabetes; herbs and spices; metabolic syndrome; nutrition;
   phytochemicals; preventative health
ID TYPE-2 DIABETES-MELLITUS; POSTPRANDIAL BLOOD-GLUCOSE; FATTY
   LIVER-DISEASE; C-REACTIVE PROTEIN; ZINGIBER-OFFICINALE SUPPLEMENTATION;
   NIGELLA-SATIVA SUPPLEMENTATION; GINGER POWDER SUPPLEMENTATION;
   RANDOMIZED CONTROLLED-TRIALS; OXIDATIVE STRESS BIOMARKERS; DOUBLE-BLIND
AB Metabolic syndrome (MetS) is a growing global health problem. Evidence suggests that diets rich in phytochemical-containing herbs and spices can contribute to reducing the risk of chronic diseases. This review assesses the scope of evidence supporting the use of herbs and spices in the diet for the prevention or treatment of MetS and its associated health conditions. A search of the PubMed, Scopus and Google Scholar databases was carried out to assess the available clinical evidence for culinary doses of commonly used herbs and spices. Trials that were measuring health factors related to metabolic disorders in healthy individuals, or the health of individuals with MetS or associated diseases, were included. Out of a total of 1738 papers identified, there were 142 relevant studies on black pepper, chilli, cardamom, cinnamon, coriander, cumin, fennel, fenugreek, garlic, ginger, nigella seed, rosemary, sage and turmeric. No relevant research was found for cloves, mint, oregano, parsley or thyme. Cinnamon, fenugreek and ginger were the herbs/spices with the most published trials on them and that showed promise for glycaemic control. Cardamom appears to have potential to reduce inflammatory markers, and cinnamon, ginger and turmeric to reduce blood lipids. Patients with type 2 diabetes were the population most likely to be included in studies, but the preventative benefits of herbs/spices in healthy populations were also investigated, particularly for chilli, ginger and cinnamon. There is evidence for the beneficial effect of culinary doses of many common herbs/spices in the prevention and treatment of MetS and associated disorders.
C1 [Mackonochie, Marion; Mills, Simon; Rolfe, Vivien] Pukka Herbs Ltd, 10 York Rd, London SE1 7ND, England.
   [Rodriguez-Mateos, Ana] Kings Coll London, Sch Life Course & Populat Sci, Fac Life Sci & Med, Dept Nutr Sci, London SE1 9NH, England.
C3 University of London; King's College London
RP Mackonochie, M (corresponding author), Pukka Herbs Ltd, 10 York Rd, London SE1 7ND, England.
EM marion.mackonochie@pukkaherbs.com; ana.rodriguez-mateos@kcl.ac.uk;
   simon.mills@pukkaherbs.com; vivien.rolfe@gmail.com
RI Rodriguez-Mateos, Ana/ABE-1560-2020
OI Rolfe, Dr Vivien/0000-0002-5489-6194; Rodriguez-Mateos,
   Ana/0000-0003-3242-402X
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NR 226
TC 8
Z9 8
U1 2
U2 15
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD DEC
PY 2023
VL 15
IS 23
AR 4867
DI 10.3390/nu15234867
PG 44
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA AB6C8
UT WOS:001116025700001
PM 38068725
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Zhang, WCB
   Xing, Y
   Shao, B
AF Zhang Wei Chun Bai
   Xing Yang
   Shao Bing
TI Serum Ferritin and the Risk of Metabolic Syndrome: A Systematic Review
   and Dose-Response Meta-Analysis of Cross-sectional Studies
SO BIOMEDICAL AND ENVIRONMENTAL SCIENCES
LA English
DT Review
DE Serum ferritin; Metabolic syndrome; Meta-analysis; Dose-response
   relationship
ID INSULIN-RESISTANCE; IRON-METABOLISM; ASSOCIATION; HYPERTENSION;
   MORTALITY; PROTEIN; STRESS; HEALTH; LEVEL; MEN
AB Objective This study aims to assess the dose-response relationship between serum ferritin (SF) and metabolic syndrome (MetS) in the two sexes.
   Methods We searched for articles on PubMed, the Cochrane Library, EMBASE, and the Web of Science databases that were published from 1950 to 2020. The summary odds ratio (OR) and 95% confidence interval (CI) of the association between SF and MetS were estimated using a random-effects model through a meta-analysis. Based on the methods described by Greenland and Longnecker, we explored the dose-response relationship between the two sexes.
   Results This study included 14 studies and 74,710 samples. The results of the classical meta-analysis showed that SF was positively associated with MetS (OR = 1.77, 95% CI: 1.59-1.98). Regarding the components of MetS (8 studies included), the results showed that SF was positively associated with abdominal obesity (OR = 1.42, 95% CI: 1.24-1.62), elevated fasting plasma glucose (OR = 1.84, 95% CI: 1.50-2.25), elevated blood pressure (OR = 1.17, 95% CI: 1.08-1.26), elevated triglycerides (OR = 2.09, 95% CI: 1.72-2.54), and reduced high-density lipoprotein cholesterol (OR = 1.33, 95% CI: 1.19-1.49). In the linear dose-response meta-analysis, the ORs of males, females, and postmenopausal females were 1.14 (95% CI: 1.13-1.16), 1.32 (95% CI: 1.26-1.39), and 1.34 (95% CI: 1.22-1.47), respectively.
   Conclusions Our study shows that SF is significantly and positively associated with MetS, and the risk in the male population is higher than that in the female population. This finding also supports the recommendation of using SF as an early warning marker of MetS.
C1 [Zhang Wei Chun Bai; Xing Yang; Shao Bing] Beijing Ctr Dis Prevent & Control, Beijing Key Lab Diagnost & Traceabil Technol Food, Beijing 100013, Peoples R China.
   [Zhang Wei Chun Bai; Shao Bing] Capital Med Univ, Sch Publ Hlth, Beijing 100069, Peoples R China.
   [Xing Yang; Shao Bing] Beijing Res Ctr Prevent Med, Beijing 100013, Peoples R China.
C3 Capital Medical University
RP Shao, B (corresponding author), Beijing Ctr Dis Prevent & Control, Beijing Key Lab Diagnost & Traceabil Technol Food, Beijing 100013, Peoples R China.; Shao, B (corresponding author), Capital Med Univ, Sch Publ Hlth, Beijing 100069, Peoples R China.; Shao, B (corresponding author), Beijing Res Ctr Prevent Med, Beijing 100013, Peoples R China.
EM shaobingch@sina.com
RI shao, bing/L-8793-2019
FU National Natural Science Foundation of China [U1736201, 2167701]
FX This study was supported by the National Natural Science Foundation of
   China [No. U1736201 and 2167701].
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NR 54
TC 12
Z9 12
U1 0
U2 10
PU CHINESE CENTER DISEASE CONTROL & PREVENTION
PI BEIJING
PA 155 CHANGBAI RD, CHANGPING DISTRICT, BEIJING, 102206, PEOPLES R CHINA
SN 0895-3988
J9 BIOMED ENVIRON SCI
JI Biomed. Environ. Sci.
PD AUG
PY 2021
VL 34
IS 8
BP 623
EP +
DI 10.3967/bes2021.086
PG 11
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA UX4KI
UT WOS:000700812200004
PM 34474722
DA 2025-06-11
ER

PT J
AU Zhang, WCB
   Du, J
   Li, H
   Yang, Y
   Cai, C
   Gao, Q
   Xing, Y
   Shao, B
   Li, G
AF Zhang, Weichunbai
   Du, Jing
   Li, Hong
   Yang, Yi
   Cai, Chang
   Gao, Qun
   Xing, Yang
   Shao, Bing
   Li, Gang
TI Multiple-element exposure and metabolic syndrome in Chinese adults: A
   case-control study based on the Beijing population health cohort
SO ENVIRONMENT INTERNATIONAL
LA English
DT Article
DE Multiple-element exposure; Metabolic syndrome; Chinese populations;
   Beijing health cohort
ID TYPE-2 DIABETES-MELLITUS; INSULIN-RESISTANCE; SELENIUM LEVELS; SERUM
   SELENIUM; CARDIOVASCULAR-DISEASE; OXIDATIVE STRESS; LIPID-METABOLISM;
   NATIONAL-HEALTH; BLOOD MERCURY; HEAVY-METALS
AB Background: Metabolic syndrome (MetS) patients have a considerably increased risk for noncommunicable diseases, which poses a serious burden on public health. The effects of different elements on MetS have received increasing attention in the field of noncommunicable diseases over the past decade. These elements can exert adverse or favourable effects on human health by synergistic or antagonistic actions. Nevertheless, few studies have explored the relationship between multiple-element exposure and MetS.
   Method: A total of 2095 MetS patients and 2039 controls free of major cardiovascular disease at baseline and follow-up visits were frequency matched for age (+/- 5 years) and sex. The internal exposure levels of 15 elements in serum were investigated. Logistic regression models were employed to estimate odds ratios (ORs) of MetS for element concentrations categorized according to quartiles in the controls.
   Result: Magnesium (Mg), selenium (Se), barium (Ba) and mercury (Hg) were significantly associated with MetS in the multi-element exposure model. The ORs for the extreme quartiles of Mg, Se, Ba, and Hg were 0.29 (95% CI: 0.23-0.37, P-trend < 0.001), 0.52 (95% CI: 0.42-0.65, P-trend < 0.001), 1.86 (95% CI: 1.51-2.28, Ptrend < 0.001), and 2.61 (95% CI: 2.11-3.22, P-trend < 0.001), respectively. Ba may be antagonistic to Mg and Se in the human body.
   Conclusions: Our study suggested that MetS was negatively associated with Mg and Se and positively associated with Ba and Hg. There were significant dose-response relationships between Mg, Se, Ba and Hg and the prevalence of MetS, suggesting that multiple elements may be involved in MetS.
C1 [Zhang, Weichunbai; Shao, Bing] Capital Med Univ, Sch Publ Hlth, 10 Xitoutiao, Beijing, Peoples R China.
   [Zhang, Weichunbai; Du, Jing; Li, Hong; Yang, Yi; Gao, Qun; Xing, Yang; Shao, Bing; Li, Gang] Beijing Ctr Dis Prevent & Control, Beijing Key Lab Diagnost & Traceabil Technol Food, Beijing, Peoples R China.
   [Cai, Chang] Murdoch Univ, Res & Innovat Off, Perth, WA, Australia.
   [Shao, Bing] China Agr Univ, Beijing Adv Innovat Ctr Food Nutr & Human Hlth, Beijing, Peoples R China.
C3 Capital Medical University; Murdoch University; China Agricultural
   University
RP Shao, B; Li, G (corresponding author), Capital Med Univ, Sch Publ Hlth, 10 Xitoutiao, Beijing, Peoples R China.
EM shaobingch@sina.com; ligang@bjcdc.org
RI shao, bing/L-8793-2019; Yang, Yi/HKF-0416-2023
OI CAI, CHANG/0000-0002-1122-3045; Yang, Yi/0000-0003-1160-3627
FU National Natural Science Foundation of China [U1736201, 2167701];
   Research Special Fund for Municipal Medical Public Welfare Institute
   [2017-BJYJ-15]
FX The authors gratefully acknowledge financial support from the National
   Natural Science Foundation of China (No. U1736201 and 2167701) and the
   Research Special Fund for Municipal Medical Public Welfare Institute
   (2017-BJYJ-15).
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NR 74
TC 35
Z9 35
U1 2
U2 59
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0160-4120
EI 1873-6750
J9 ENVIRON INT
JI Environ. Int.
PD OCT
PY 2020
VL 143
AR 105959
DI 10.1016/j.envint.2020.105959
PG 9
WC Environmental Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology
GA PK2YU
UT WOS:000602318000008
PM 32673904
OA gold
DA 2025-06-11
ER

PT J
AU Hassan, NA
   El Bassossy, HM
   Fahmy, A
   Mahmoud, MF
AF Hassan, Noura A.
   El Bassossy, Hany M.
   Fahmy, Ahmed
   Mahmoud, Mona F.
TI Limonin alleviates macro- and micro-vascular complications of metabolic
   syndrome in rats: A comparative study with azelnidipine
SO PHYTOMEDICINE
LA English
DT Article
DE Metabolic syndrome; Vascular reactivity; Aorta; Limonin; Azelnidipine
ID CALCIUM-CHANNEL BLOCKER; SYMPATHETIC-NERVOUS-SYSTEM; INSULIN-RESISTANCE;
   VASCULAR REACTIVITY; CITRUS LIMONOIDS; OXIDATIVE STRESS; HYPERTENSIVE
   PATIENTS; CARDIAC FIBROSIS; LIVER; INHIBITION
AB Background: Hypertension is a serious component of metabolic syndrome (MetS).
   Hypothesis: This research investigates the potential protective effect of limonin against MetS-associated hypertension in comparison with azelnidipine, a common calcium channel blocker.
   Study design: MetS was induced in rats by 10% fructose in water and 3% salt in diet over a 16-week period. Limonin (50 mg/kg) and azelnidipine (5 mg/kg) were administered daily in the last four weeks
   Methods: Non-invasive blood pressure (BP) was recorded in conscious animals. Concentration-response curves for phenylephrine (PE) and acetylcholine (ACh) were analysed in thoracic aorta (macrovessels) and kidney microvessels. Blood glucose level, serum insulin level, advanced glycation end products (AGEs), tumor necrosis factor-alpha (TNF alpha), malondialdehyde (MDA) and transforming growth factor-beta (TGF-beta 1) were determined.
   Results: Limonin alleviated elevations in systolic and diastolic BP associated with MetS similar to levels associated with azelnidipine. Limonin prevented the MetS induced exaggerated macro- and micro-vascular contractility to PE and the impaired dilatation to ACh. However, in vitro incubation with limonin partially alleviated the deteriorated vascular reactivity of aorta isolated from MetS animals or AGEs injured aorta. Limonin did not have direct relaxant effect on the isolated vessel. On the other hand, limonin reduced the elevated serum levels of AGEs, TNF-alpha and MDA. Limonin suppressed the vascular fibrosis through reducing the elevated serum level of TGF-beta 1 and excessive aortic collagen deposition. Limonin decreased the elevated HOMA-IR in MetS animals.
   Conclusion: Limonin offsets the hypertensive and vascular impairment associated with MetS via attenuation of inflammation and fibrosis. Its impact is comparable to that of azelnidipine.
C1 [Hassan, Noura A.; El Bassossy, Hany M.; Fahmy, Ahmed; Mahmoud, Mona F.] Zagazig Univ, Fac Pharm, Dept Pharmacol & Toxicol, Zagazig 44519, Egypt.
   [El Bassossy, Hany M.] King Abdulaziz Univ, Dept Pharmacol & Toxicol, Fac Pharm, Jeddah 21589, Saudi Arabia.
C3 Egyptian Knowledge Bank (EKB); Zagazig University; King Abdulaziz
   University
RP Hassan, NA (corresponding author), Zagazig Univ, Fac Pharm, Dept Pharmacol & Toxicol, Zagazig 44519, Egypt.
EM nouraeldeb@yahoo.com
RI Hassan, Noura/GXN-4621-2022; El-Bassossy, Hany/NKQ-3705-2025; Mahmoud,
   Mona/Q-8851-2019; El-Bassossy, Hany/I-1576-2012
OI Mahmoud, Mona/0000-0002-5312-2066; El-Bassossy, Hany/0000-0002-6838-6945
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NR 79
TC 28
Z9 28
U1 0
U2 20
PU ELSEVIER GMBH
PI MUNICH
PA HACKERBRUCKE 6, 80335 MUNICH, GERMANY
SN 0944-7113
EI 1618-095X
J9 PHYTOMEDICINE
JI Phytomedicine
PD APR 1
PY 2018
VL 43
BP 92
EP 102
DI 10.1016/j.phymed.2018.03.044
PG 11
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA GG5GD
UT WOS:000432722700012
PM 29747759
DA 2025-06-11
ER

PT J
AU Yokota, T
   Kinugawa, S
   Hirabayashi, K
   Suga, T
   Takada, S
   Omokawa, M
   Kadoguchi, T
   Takahashi, M
   Fukushima, A
   Matsushima, S
   Yamato, M
   Okita, K
   Tsutsui, H
AF Yokota, Takashi
   Kinugawa, Shintaro
   Hirabayashi, Kagami
   Suga, Tadashi
   Takada, Shingo
   Omokawa, Masashi
   Kadoguchi, Tomoyasu
   Takahashi, Masashige
   Fukushima, Arata
   Matsushima, Shouji
   Yamato, Mayumi
   Okita, Koichi
   Tsutsui, Hiroyuki
TI Pioglitazone improves whole-body aerobic capacity and skeletal muscle
   energy metabolism in patients with metabolic syndrome
SO JOURNAL OF DIABETES INVESTIGATION
LA English
DT Article
DE Clinical; Metabolic syndrome; Treatment drug
ID LOW CARDIORESPIRATORY FITNESS; IMPAIRED GLUCOSE-TOLERANCE; TYPE-2
   DIABETES-MELLITUS; INSULIN SENSITIVITY; MITOCHONDRIAL-FUNCTION; EXERCISE
   CAPACITY; OXIDATIVE STRESS; FAT; MORTALITY; MEN
AB Aims/Introduction: Low aerobic capacity is a strong and independent predictor of all-cause mortality in patients with metabolic syndrome (MetS). Here, we investigated the effects of pioglitazone treatment on whole-body aerobic capacity and skeletal muscle energy metabolism in MetS patients.
   Materials and Methods: A total of 14 male patients with MetS received oral pioglitazone 15 mg/day for 4 months. To assess whole-body aerobic capacity, exercise testing with a bicycle ergometer was carried out before and after pioglitazone treatment. To assess skeletal muscle energy metabolism, intramyocellular lipid in the resting leg and high-energy phosphates in the calf muscle during plantar-flexion exercise were measured using (1)proton-and (31)phosphorus magnetic resonance spectroscopy, respectively.
   Results: Pioglitazone significantly increased peak oxygen uptake (25.1 +/- 4.9 mL/kg/min pretreatment vs 27.2 +/- 3.9 mL/kg/min post-treatment, P < 0.05) and anaerobic threshold (12.7 +/- 1.9 mL/kg/min pretreatment vs 13.6 +/- 1.6 mL/kg/min post-treatment, P < 0.05), although daily physical activity was comparable before and after the treatment. Intramyocellular lipid content was significantly reduced after pioglitazone treatment by 26%, indicating improved skeletal muscle fatty acid metabolism. Pioglitazone also significantly decreased the muscle phosphocreatine loss during exercise by 13%, indicating improved skeletal muscle high-energy phosphate metabolism. Notably, the increase in anaerobic threshold; that is, submaximal aerobic capacity, closely correlated with the decrease in intramyocellular lipid content after pioglitazone treatment.
   Conclusions: Pioglitazone significantly improved the MetS patients' whole-body aerobic capacity and skeletal muscle energy metabolism. The beneficial effect of pioglitazone on whole-body aerobic capacity might be at least in part through improved fatty acid metabolism in the skeletal muscle.
C1 [Yokota, Takashi; Kinugawa, Shintaro; Hirabayashi, Kagami; Suga, Tadashi; Takada, Shingo; Kadoguchi, Tomoyasu; Takahashi, Masashige; Fukushima, Arata; Matsushima, Shouji; Tsutsui, Hiroyuki] Hokkaido Univ, Dept Cardiovasc Med, Grad Sch Med, Sapporo, Hokkaido, Japan.
   [Omokawa, Masashi; Okita, Koichi] Hokusho Univ, Dept Sports Educ, Ebetsu, Hokkaido, Japan.
   [Yamato, Mayumi] Kyushu Univ, Innovat Ctr Med Redox Nav, Fukuoka, Japan.
C3 Hokkaido University; Kyushu University
RP Kinugawa, S (corresponding author), Hokkaido Univ, Dept Cardiovasc Med, Grad Sch Med, Sapporo, Hokkaido, Japan.
EM tuckahoe@med.hokudai.ac.jp
RI matsushima, shouji/IUO-9529-2023; Kinugawa, Shintaro/E-1268-2012
OI Kadoguchi, Tomoyasu/0000-0001-6336-5160
FU Ministry of Education, Culture, Sports, Science and Technology of Japan
   [18790487, 17390223, 20117004, 21390236]; Meiji Yasuda Life Foundation
   of Health and Welfare; Mitsui Life Social Welfare Foundation; Uehara
   Memorial Foundation; Mochida Memorial Foundation for Medical and
   Pharmaceutical Research; Center of Innovation Program from Japan Science
   and Technology Agency (JST); Grants-in-Aid for Scientific Research
   [26750331, 17390223, 21390236, 17K09581, 16K16607, 20117004, 15K16497,
   15H04815, 15K01625, 18790487] Funding Source: KAKEN
FX We thank Miwako Fujii, Akiko Aita and Kaoruko Kawai for their technical
   assistance. This study was supported by grants from the Ministry of
   Education, Culture, Sports, Science and Technology of Japan (grant no.
   18790487, 17390223, 20117004 and 21390236); the Meiji Yasuda Life
   Foundation of Health and Welfare; the Mitsui Life Social Welfare
   Foundation; the Uehara Memorial Foundation; the Mochida Memorial
   Foundation for Medical and Pharmaceutical Research; and the Center of
   Innovation Program from Japan Science and Technology Agency (JST).
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NR 26
TC 25
Z9 29
U1 1
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2040-1124
J9 J DIABETES INVEST
JI J. Diabetes Investig.
PD JUL
PY 2017
VL 8
IS 4
BP 535
EP 541
DI 10.1111/jdi.12606
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA EZ7PE
UT WOS:000404917100017
PM 27930876
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Potz, BA
   Sabe, AA
   Elmadhun, NY
   Clements, RT
   Abid, MR
   Sodha, NR
   Sellke, FW
AF Potz, Brittany A.
   Sabe, Ashraf A.
   Elmadhun, Nassrene Y.
   Clements, Richard T.
   Abid, M. Ruhul
   Sodha, Neel R.
   Sellke, Frank W.
TI Calpain inhibition modulates glycogen synthase kinase 3β pathways in
   ischemic myocardium: A proteomic and mechanistic analysis
SO JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
LA English
DT Article
DE calpain inhibition; chronic myocardial ischemia; metabolic syndrome;
   angiogenesis
ID OXIDATIVE STRESS; SWINE MODEL; PHOSPHORYLATION; ACTIVATION; GSK-3-BETA;
   CLEAVAGE; GROWTH
AB Background: Calpain inhibition has an enhancing effect on myocardial perfusion and improves myocardial density by inhibiting glycogen synthase kinase 3 beta (GSK-3 beta) and up-regulating downstream signaling pathways, including the insulin/PI3K and WNT/b-catenin pathways, in a pig model of chronic myocardial ischemia in the setting of metabolic syndrome.
   Methods: Pigs were fed a high-fat diet for 4 weeks, then underwent placement of an ameroid constrictor to the left circumflex artery. Three weeks later, the animals received no drug (high-cholesterol controls [HCC]), a high-dose calpain inhibitor (HCI), a low-dose calpain inhibitor (LCI), or a GSK-3 beta inhibitor (GSK-3 beta I). The diets and drug regimens were continued for 5 weeks and the myocardial tissue was harvested.
   Results: Calpain and GSK-3 beta inhibition caused an increase in myocardial perfusion ratios at rest and during pacing compared with controls. Pigs in the LCI and HCI groups had increased vessel density in the ischemic myocardium, and pigs in the GSK-3 beta I group had increased vessel density in the ischemic and nonischemic myocardium compared with the HCC group. Calpain inhibition modulates proteins involved in the insulin/PI3K and WNT/b-catenin pathways. Quantitative proteomics revealed that calpain and GSK-3 beta inhibition significantly modulated the expression of proteins enriched in cytoskeletal regulation, metabolism, respiration, and calcium-binding pathways.
   Conclusions: In the setting of metabolic syndrome, calpain or GSK-3 beta inhibition increases vessel density in both ischemic and nonischemic myocardial tissue. Calpain inhibition may exert these effects through the inhibition of GSK-3 beta and up-regulation of downstream signaling pathways, including the insulin/ PI3K and WNT/b-catenin pathways.
C1 [Potz, Brittany A.; Sabe, Ashraf A.; Elmadhun, Nassrene Y.; Clements, Richard T.; Abid, M. Ruhul; Sodha, Neel R.; Sellke, Frank W.] Alpert Med Sch Brown Univ, Rhode Isl Hosp, Dept Surg, Div Cardiothorac Surg, Providence, RI USA.
C3 Lifespan Health Rhode Island; Rhode Island Hospital; Brown University
RP Sellke, FW (corresponding author), Div Cardiothorac Surg, 2 Dudley St,,MOC 360, Providence, RI 02905 USA.
EM fsellke@lifespan.org
FU National Heart, Lung, and Blood Institute [R01 HL46716, R01 HL128831];
   National Institute of General Medical Sciences (NIGMS) Training Grant
   [2T32 GM065085]; National Institutes of Health Training Grant
   [5T32-HL094300-03]; American Heart Association (AHA) [GRNT20460376];
   NIGMS Grant [1P20GM103652]; AHA [14GRNT20460291]; American Heart
   Association (AHA) [14GRNT20460291] Funding Source: American Heart
   Association (AHA)
FX Funding for this research was provided by the National Heart, Lung, and
   Blood Institute (R01 HL46716 and R01 HL128831, to Dr Sellke), National
   Institute of General Medical Sciences (NIGMS) Training Grant 2T32
   GM065085 (to Dr Potz), National Institutes of Health Training Grant
   5T32-HL094300-03 (to Drs Sabe and Elmadhun), American Heart Association
   (AHA) Grant-in Aid GRNT20460376 (to Dr Clements), NIGMS Grant
   1P20GM103652 (Project 3; to Dr Abid), and AHA Grant-in-Aid
   14GRNT20460291 (to Dr Abid).
CR Abid MR, 2006, J BIOL CHEM, V281, P35544, DOI 10.1074/jbc.M608620200
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NR 30
TC 18
Z9 22
U1 0
U2 5
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0022-5223
EI 1097-685X
J9 J THORAC CARDIOV SUR
JI J. Thorac. Cardiovasc. Surg.
PD FEB
PY 2017
VL 153
IS 2
BP 342
EP 357
DI 10.1016/j.jtcvs.2016.09.087
PG 16
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA EO7TY
UT WOS:000396894200049
PM 27986275
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Shih, SL
   Lin, YS
   Lin, SY
   Hou, WC
AF Shih, Shen-Liang
   Lin, Yin-Shiou
   Lin, Shyr-Yi
   Hou, Wen-Chi
TI Effects of yam dioscorin interventions on improvements of the metabolic
   syndrome in high-fat diet-induced obese rats
SO BOTANICAL STUDIES
LA English
DT Article
DE Dioscorin; Dipeptidyl peptidase IV (DPP IV); Metabolic syndrome (MS);
   Peptic hydrolysates; Systolic blood pressure; Yam
ID DIPEPTIDYL-PEPTIDASE-IV; TUBER STORAGE PROTEIN; COMPUTER-AIDED
   SIMULATION; TAINONG NO. 1; ANTIOXIDANT ACTIVITIES; OXIDATIVE STRESS;
   INSULIN-RESISTANCE; GLUCOSE-TOLERANCE; PEPSIN HYDROLYSIS; BLOOD-PRESSURE
AB Background: The metabolic syndrome (MS) is termed a cluster of multiple metabolic risk criteria which is positively correlated with cardiovascular disease and type 2 diabetes mellitus (DM). Yam dioscorins have been reported to exhibit biological activities, however, little is known their preventive effects on the MS. Therefore, a high-fat (HF) diet was used to induce Wistar rat obesity and then yam dioscorin (50 mg/kg, dio50) was intervened daily concurrent HF diet (HF diet + dio50) for five weeks to check the changes of weights of body and tissues, blood pressures, and impaired glucose tolerances. The in vitro peptic hydrolysates of dioscorin with molecular mass between 3 kDa and 10 kDa and less than 3 kDa were used to determine dipeptidyl peptidase IV (DPP IV) inhibitory activities which DPP IV inhibitor has been reported to prevent and treat type 2 DM.
   Results: There were no significant difference in body weights, feed intakes, feed conversion, and weights of adipose tissues of obese rats in groups of HF and (HF diet + dio50). However, the systolic blood pressures in obese rats of 2-, 3-and 4-week dioscorin interventions were showed significantly lower (P < 0.05) compared to the HF group. The dioscorin intervention (HF+ dio50) was showed significantly different (P < 0.05) and improved the impaired glucose tolerances compared to HF group in obese rats by the oral glucose tolerance tests. It was also found that the fraction with different molecular mass of dioscorin peptic hydrolysates (5 mg/ml) showed inhibitory activities against DPP IV using sitagliptin phosphate as positive controls.
   Conclusions: Yam dioscorins exhibit improved MS activities in obese rats which the related mechanisms may need further investigations.
C1 [Shih, Shen-Liang] Yuans Gen Hosp, Dept Breast Surg & Canc Ctr, Kaohsiung, Taiwan.
   [Lin, Yin-Shiou; Hou, Wen-Chi] Taipei Med Univ, Grad Inst Pharmacognosy, Taipei, Taiwan.
   [Lin, Shyr-Yi] Taipei Med Univ Hosp, Dept Primary Care Med, Taipei, Taiwan.
   [Lin, Shyr-Yi] Taipei Med Univ, Sch Med, Dept Gen Med, Taipei, Taiwan.
   [Hou, Wen-Chi] Taipei Med Univ Hosp, Tradit Herbal Med Res Ctr, Taipei, Taiwan.
   [Hou, Wen-Chi] Taipei Med Univ, Program Clin Drug Discovery Bot Herbs, Taipei, Taiwan.
C3 Taipei Medical University; Taipei Medical University; Taipei Medical
   University Hospital; Taipei Medical University; Taipei Medical
   University Hospital; Taipei Medical University; Taipei Medical
   University
RP Lin, SY (corresponding author), Taipei Med Univ Hosp, Dept Primary Care Med, Taipei, Taiwan.
EM sylin@tmu.edu.tw; wchou@tmu.edu.tw
RI Zhang, Wentao/T-4790-2019
OI Hou, Wen-Chi/0000-0002-9565-7018; shih, shen liang/0000-0001-8488-5931
FU Yuan's General Hospital, Kaohsiung, Taiwan [103YGH-TMU-02-3]; Ministry
   of Science and Technology, Republic of China [NSC
   102-2313-B-038-004-MY3]
FX The authors would like to express thanks to Yuan's General Hospital,
   Kaohsiung, Taiwan (103YGH-TMU-02-3) and Ministry of Science and
   Technology, Republic of China (NSC 102-2313-B-038-004-MY3) for financial
   supports.
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NR 49
TC 14
Z9 15
U1 0
U2 13
PU SPRINGEROPEN
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
EI 1999-3110
J9 BOT STUD
JI Bot. Stud.
PD FEB 25
PY 2015
VL 56
AR 4
DI 10.1186/s40529-015-0084-8
PG 9
WC Plant Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences
GA CJ3RA
UT WOS:000355400400001
PM 28510813
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Manenschijn, L
   van Kruysbergen, RGPM
   de Jong, FH
   Koper, JW
   van Rossum, EFC
AF Manenschijn, Laura
   van Kruysbergen, Rulanda G. P. M.
   de Jong, Frank H.
   Koper, Jan W.
   van Rossum, Elisabeth F. C.
TI Shift Work at Young Age Is Associated with Elevated Long-Term Cortisol
   Levels and Body Mass Index
SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Article
ID METABOLIC SYNDROME; BIOMARKER; ROTATION; RHYTHMS; HEALTH; SLEEP; HAIR
AB Background: The incidence of obesity and other features of the metabolic syndrome is increased in shift workers. This may be due to a misalignment between the internal circadian rhythm and the behavioral rhythm. The stress hormone cortisol could play a role in this phenomenon because it is secreted in a circadian rhythm, and long-term elevated cortisol leads to components of the metabolic syndrome. We compared cortisol levels in scalp hair of shift and day workers to study changes in long-term cortisol due to shift work.
   Methods: Hair samples were collected from 33 shift workers and 89 day workers. Cortisol was extracted from the hair samples with methanol, and cortisol levels were measured using ELISA. Height and weight were measured, and body mass index (BMI) was calculated.
   Results: Shift workers had higher hair cortisol levels than day workers: 47.32 pg/mg hair [95% confidence interval (CI) = 38.37-58.21] vs. 29.72 pg/mg hair (95% CI = 26.18-33.73) (P < 0.001). When divided in age groups based on the median age, elevated cortisol levels were present only in younger shift workers: 48.53 pg/mg hair (95% CI = 36.56-64.29) vs. 26.42 pg/mg hair (95% CI = 22.91-30.55) (P < 0.001). BMI was increased in younger shift workers as well: 27.2 (95% CI = 25.5-28.8) vs. 23.7 (95% CI = 22.8-24.7) in young day workers (P = 0.001). Hair cortisol and BMI were positively correlated (beta = 0.262; P = 0.005).
   Conclusion: Shift work at a young adult age is associated with elevated long-term cortisol levels and increased BMI. Elevated cortisol levels and BMI may contribute to the increased cardiovascular risk found in shift workers. (J Clin Endocrinol Metab 96: E1862-E1865, 2011)
C1 [Manenschijn, Laura; de Jong, Frank H.; Koper, Jan W.; van Rossum, Elisabeth F. C.] Erasmus MC, Dept Internal Med, NL-3000 CA Rotterdam, Netherlands.
   [van Kruysbergen, Rulanda G. P. M.] Arbo Unie Nijverdal, NL-7442 AC Nijverdal, Netherlands.
C3 Erasmus University Rotterdam; Erasmus MC
RP Manenschijn, L (corresponding author), Erasmus MC, Dept Internal Med, Room Ee 542,POB 2040, NL-3000 CA Rotterdam, Netherlands.
EM l.manenschijn@erasmusmc.nl
RI van Rossum, Elisabeth/AAP-9388-2020; De Jong, Frank/A-9876-2011
OI van Rossum, Elisabeth/0000-0003-0120-4913
FU Netherlands Organization for Scientific Research (NWO) [916.96.069]
FX This work was supported by the Netherlands Organization for Scientific
   Research (NWO) Grant 916.96.069.
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NR 19
TC 165
Z9 191
U1 0
U2 30
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0021-972X
EI 1945-7197
J9 J CLIN ENDOCR METAB
JI J. Clin. Endocrinol. Metab.
PD NOV
PY 2011
VL 96
IS 11
BP E1862
EP E1865
DI 10.1210/jc.2011-1551
PG 4
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 844MF
UT WOS:000296750600020
PM 21880805
OA Bronze
DA 2025-06-11
ER

PT J
AU Ahmad, SR
   Zeyaullah, M
   Alshahrani, AM
   Khan, MS
   Dawria, A
   Mohieldin, A
   Ali, H
   Altijani, AAG
   Alam, MS
   Mehdi, M
   Akram, S
   Hussain, ER
   Kamal, MA
AF Ahmad, S. Rehan
   Zeyaullah, Md
   Alshahrani, Abdullah M.
   Khan, Mohammad Suhail
   Dawria, Adam
   Mohieldin, Ali
   Ali, Haroon
   Altijani, Abdelrhman A. G.
   Alam, Mohammad Shane
   Mehdi, Munzila
   Akram, Sabika
   Hussain, Ejaz Rizvi
   Kamal, Mohammad Amjad
TI Unlocking the potential of lumateperone and novel anti-psychotics for
   schizophrenia
SO BIOIMPACTS
LA English
DT Article
DE Schizophrenia; Treatment; Anti-psychotics; Lumateperone
ID D2-DOPAMINE RECEPTOR OCCUPANCY; SEROTONIN STABILIZER RP5063;
   DOUBLE-BLIND; ADJUNCTIVE PIMAVANSERIN; DOPAMINE-D-2 RECEPTORS;
   INADEQUATE RESPONSE; NEGATIVE SYMPTOMS; CLINICAL-TRIALS; PHASE-3 TRIAL;
   LONG-TERM
AB Schizophrenia is a devastating chronic mental health illness which includes a complex set of symptoms like hallucination, illusion and delusion, and to manage, lifelong antipsychotic medications are needed. Schizophrenia affects 1% of the population worldwide, and to date, two different classes of antipsychotics, i.e., typical and atypical antipsychotics, are available in the market, and there is an urgent need for promising antipsychotic drugs. In this review, we focus on recently approved antipsychotics and then focus on different antipsychotic drugs under clinical trials. In this review, we first focus on lumateperone in detail, which was approved in December 2019 by the Food and Drug Administration (FDA) and simultaneously modulates serotonin, glutamate and dopamine neurotransmitters and is used at doses of 10.5-, 21- and 42 mg, which show mild adverse effects like constipation, sedation, somnolence and fatigue. This review also focuses on a few more emerging antipsychotics like brexpiprazole, brilaroxazine, roluperidone, F17464, pimavanserin (ACP-103), xanomeline, BI 409306, BI 425809 and MK-8189 which are under different phase of clinical trials and might get approved soon. Brexpiprazole and brilaroxazine act on dopamine receptors, whereas xanomeline, pimavanserin and roluperidone do not act on D2 receptors and manage the symptoms. All the antipsychotic drugs covered did not show any other severe adverse effects except gastrointestinal issues and cardiometabolic risk factors. However, still rigorous clinical trials and modifications are needed to manage adverse effects, and we can expect a few antipsychotics to be on the market soon.
C1 [Ahmad, S. Rehan] West Bengal State Univ, Hiralal Mazumdar Mem Coll Women, Kolkata 700035, W Bengal, India.
   [Zeyaullah, Md; Alshahrani, Abdullah M.] King Khalid Univ, Coll Appl Med Sci, Dept Basic Med Sci, Khamis Mushayt Campus, Abha 62561, Saudi Arabia.
   [Khan, Mohammad Suhail; Dawria, Adam; Mohieldin, Ali; Ali, Haroon; Altijani, Abdelrhman A. G.] King Khalid Univ, Coll Appl Med Sci, Dept Publ Hlth, Khamis Mushait Campus, Abha 62561, Saudi Arabia.
   [Alam, Mohammad Shane] Jazan Univ, Coll Appl Med Sci, Dept Med Lab Technol, Jizan 45142, Saudi Arabia.
   [Mehdi, Munzila; Akram, Sabika; Hussain, Ejaz Rizvi] Aligarh Muslim Univ, Dept Bot, Aligarh 202002, Uttar Pradesh, India.
   [Kamal, Mohammad Amjad] Sichuan Univ, West China Hosp, Frontiers Sci Ctr Dis Related Mol Network, Inst Syst Genet,Joint Lab Artificial Intelligence, Chengdu 610000, Sichuan, Peoples R China.
   [Kamal, Mohammad Amjad] Sichuan Univ, West China Hosp, West China Sch Nursing, Chengdu 610000, Sichuan, Peoples R China.
   [Kamal, Mohammad Amjad] Daffodil Int Univ, Fac Allied Hlth Sci, Dept Pharm, Dhaka 1207, Bangladesh.
   [Kamal, Mohammad Amjad] Novel Global Community Educ Fdn, Peterlee Pl, Hebersham, NSW 2770, Australia.
C3 West Bengal State University; King Khalid University; King Khalid
   University; Jazan University; Aligarh Muslim University; Sichuan
   University; Sichuan University; Daffodil International University
RP Ahmad, SR (corresponding author), West Bengal State Univ, Hiralal Mazumdar Mem Coll Women, Kolkata 700035, W Bengal, India.; Zeyaullah, M (corresponding author), King Khalid Univ, Coll Appl Med Sci, Dept Basic Med Sci, Khamis Mushayt Campus, Abha 62561, Saudi Arabia.
EM professor.rehaan@gmail.com; mdhafed@kku.edu.sa
RI KHAN, MOHAMMAD ZUBAIR/D-4478-2012; Kamal, Mohammad/J-2918-2014;
   Alshahrani, Abdullah/HKP-2111-2023; Ahmad, S Rehan/JXM-4746-2024;
   Galaleldin Altijani, Abdelrhman Ahmed/IUO-4174-2023; Zeyaullah,
   Md/JMH-3212-2023
OI Alam, Mohammad/0000-0003-4775-5411; Ahmad, S Rehan/0000-0003-0796-5238;
   Zeyaullah, Md./0000-0003-0573-4129
FU Deanship of Research and Graduate Studies at King Khalid University
   [RGP2/257/45]
FX The authors extend their appreciation to the Deanship of Research and
   Graduate Studies at King Khalid University for funding this through a
   large research project under grant number RGP2/257/45.
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NR 113
TC 0
Z9 0
U1 4
U2 8
PU TABRIZ UNIV MEDICAL SCIENCES & HEALTH SERVICES
PI TABRIZ
PA DANESHGHAH ST, TABRIZ, REPUBLIC ISLAMIC 51664-14766, IRAN
SN 2228-5652
EI 2228-5660
J9 BIOIMPACTS
JI BioImpacts
PD SEP 9
PY 2024
VL 15
DI 10.34172/bi.30259
EA SEP 2024
PG 19
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA W6Z3E
UT WOS:001310441400001
PM 40161932
OA gold
DA 2025-06-11
ER

PT J
AU Kamil, A
   Chen, CYO
AF Kamil, Alison
   Chen, C. -Y. Oliver
TI Health Benefits of Almonds beyond Cholesterol Reduction
SO JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
LA English
DT Review
DE almonds; anti-inflammation; antioxidation; body weight; cholesterol;
   glucoregulation
ID CORONARY-HEART-DISEASE; C-REACTIVE PROTEIN; RISK-FACTORS; POSTPRANDIAL
   GLYCEMIA; MONOUNSATURATED FAT; LIPID-PEROXIDATION; PLASMA-LIPIDS;
   SERUM-LIPIDS; BODY-WEIGHT; CONSUMPTION
AB Almonds are rich in monounsaturated fat, fiber, alpha-tocopherol, minerals such as magnesium and copper, and phytonutrients, albeit being energy-dense. The favorable fat composition and fiber contribute to the hypocholesterolemic benefit of almond consumption. By virtue of their unique nutrient composition, almonds are likely to benefit other modifiable cardiovascular and diabetes risks, such as body weight, glucose homeostasis, inflammation, and oxidative stress. This paper briefly reviews the nutrient composition and hypocholesterolemic benefits; the effects of almond consumption on body weight, glucose regulation, oxidative stress, and inflammation, based on the data of clinical trials, will then be discussed. Although more studies are definitely warranted, the emerging evidence supports that almond consumption beneficially influences chronic degenerative disease risk beyond cholesterol reduction, particularly in populations with metabolic syndrome and type 2 diabetes mellitus.
C1 [Kamil, Alison; Chen, C. -Y. Oliver] Tufts Univ, Antioxidants Res Lab, Jean Mayer USDA Human Nutr Res Ctr Aging, Boston, MA 02111 USA.
C3 Tufts University; United States Department of Agriculture (USDA)
RP Chen, CYO (corresponding author), Tufts Univ, Antioxidants Res Lab, Jean Mayer USDA Human Nutr Res Ctr Aging, 711 Washington St, Boston, MA 02111 USA.
EM oliver.chen@tufts.edu
RI Chen, Yung-Chung/GRY-3101-2022
FU U.S. Department of Agriculture (USDA)/Agricultural Research Service
   Cooperative Agreement [58-1950-7-707]; Almond Board of California
FX Supported by U.S. Department of Agriculture (USDA)/Agricultural Research
   Service Cooperative Agreement 58-1950-7-707 and a grant from the Almond
   Board of California. The contents of this publication do not necessarily
   reflect the views or policies of the USDA nor does mention of trade
   names, commercial products, or organizations imply endorsement by the
   U.S. government.
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NR 58
TC 72
Z9 83
U1 2
U2 91
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0021-8561
EI 1520-5118
J9 J AGR FOOD CHEM
JI J. Agric. Food Chem.
PD JUL 11
PY 2012
VL 60
IS 27
SI SI
BP 6694
EP 6702
DI 10.1021/jf2044795
PG 9
WC Agriculture, Multidisciplinary; Chemistry, Applied; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture; Chemistry; Food Science & Technology
GA 972RO
UT WOS:000306297800006
PM 22296169
DA 2025-06-11
ER

PT J
AU Zarich, SW
AF Zarich, Stuart W.
TI Mechanism by which hyperglycemia plays a role in the setting of acute
   cardiovascular illness
SO REVIEWS IN CARDIOVASCULAR MEDICINE
LA English
DT Article
DE hyperglycemia; acute coronary syndromes; diabetes mellitus
ID ACUTE MYOCARDIAL-INFARCTION; GLUCOSE-INSULIN-POTASSIUM;
   DIABETES-MELLITUS; STRESS HYPERGLYCEMIA; METABOLIC SYNDROME; OXIDATIVE
   STRESS; BLOOD-GLUCOSE; RISK-FACTOR; MORTALITY; DYSFUNCTION
AB Acute hyperglycemia is associated with excess morbidity and mortality in acute cardiovascular illness in both diabetic and nondiabetic patients. Hyperglycemia is associated with altered myocardial energetics, but abnormalities in glucose oxidation and glycolysis do not fully account for this excess risk. Hyperglycemia leads to a pro-oxidative/ proinflammatory state that is associated with endothelial dysfunction, diminished coronary vasodilatory reserve, and a prothrombotic state. Hyperglycemia negates the protective effect of ischemic preconditioning and, most importantly, appears to interfere with the salutary effects of insulin in acute cardiovascular illness. Aggressive therapy with continuous infusion of insulin seems to improve a host of metabolic and physiologic effects associated with acute hyperglycemia and appears warranted if euglycemia can be maintained.
C1 Bridgeport Hosp, Div Cardiovasc Med, Bridgeport, CT 06610 USA.
   Yale Univ, Sch Med, New Haven, CT USA.
C3 Yale University
RP Zarich, SW (corresponding author), Bridgeport Hosp, Div Cardiovasc Med, Bridgeport, CT 06610 USA.
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NR 51
TC 9
Z9 12
U1 0
U2 5
PU IMR PRESS
PI ROBINSON
PA 112 ROBINSON RD, ROBINSON, SINGAPORE
SN 1530-6550
EI 2153-8174
J9 REV CARDIOVASC MED
JI Rev. Cardiovasc. Med.
PY 2006
VL 7
SU 2
BP S35
EP S43
PG 9
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 124HZ
UT WOS:000243360200006
PM 17224876
DA 2025-06-11
ER

PT J
AU O'Reilly, SL
   Leonard, Y
   Dasgupta, K
   Maindal, HT
AF O'Reilly, Sharleen L.
   Leonard, Yvonne
   Dasgupta, Kaberi
   Terkildsen Maindal, Helle
TI Diabetes after pregnancy prevention trials: Systematic review for core
   outcome set development
SO MATERNAL AND CHILD NUTRITION
LA English
DT Review
DE core outcome set; diabetes prevention; gestational diabetes
ID LIFE-STYLE INTERVENTION; RISK PERCEPTION; FOLLOW-UP; WOMEN; MELLITUS;
   WEIGHT; METFORMIN; EXERCISE; COHORT; BIRTH
AB Diabetes prevention intervention studies in women with previous gestational diabetes have increased, but no consensus exists on core outcomes to support comparisons and synthesis of findings. We aimed to systematically catalogue outcomes in diabetes after pregnancy prevention interventions with the goal of developing a core outcome set. Embase, Medline, Cochrane Library, Cochrane Pregnancy and Childbirth Trials Register, and CINAHL were searched from inception to October 2017. Post-partum lifestyle and diabetes screening intervention studies in women with previous gestational diabetes and/or their families were eligible. No limits were placed on intervention type, duration, or location. Two authors independently screened and performed data extraction on outcomes, measurement tools, and relevant study characteristics. We analysed data from 38 studies (29 randomised controlled trials and 9 pre-post intervention evaluations) comprising 12,509 participants. Most publications (80%) occurred between the years 2012 and 2017. Among 172 outcomes, we identified 36 outcome groups and classified them under three domains: health status (body weight, body composition, diabetes risk, cardiometabolic risk, diabetes development, mental health, pregnancy outcomes, and fitness), health behaviours (dietary, physical activity, diabetes screening, behaviour change, and breastfeeding), and intervention processes (implementation). The health status domain contained the most commonly reported outcomes, but measurement tools were very heterogeneous. Despite the recent explosion in diabetes after pregnancy prevention studies, large variation in outcomes and measurement methods exists. Research is needed to define a core outcome set to standardise diabetes after pregnancy prevention interventions. The core outcome set should engage a wide group of stakeholders to identify impactful indicators for future trials.
C1 [O'Reilly, Sharleen L.] Univ Coll Dublin, UCD Inst Food & Hlth, Sch Agr & Food Sci, Dublin, Ireland.
   [O'Reilly, Sharleen L.; Leonard, Yvonne] Univ Coll Dublin, Sch Agr & Food Sci, Dublin 4, Ireland.
   [Dasgupta, Kaberi] McGill Univ, Ctr Hlth, Res Inst, Ctr Outcomes Res & Evaluat, Montreal, PQ, Canada.
   [Terkildsen Maindal, Helle] Aarhus Univ, Sect Hlth Promot & Hlth Serv Res, Aarhus, Denmark.
C3 University College Dublin; University College Dublin; McGill University;
   Aarhus University
RP O'Reilly, SL (corresponding author), Univ Coll Dublin, Sch Agr & Food Sci, Dublin 4, Ireland.
EM sharleen.oreilly@ucd.ie
RI Maindal, Helle/N-8916-2016; O'Reilly, Sharleen/N-3412-2015
OI Maindal, Helle Terkildsen/0000-0003-0525-7254; O'Reilly,
   Sharleen/0000-0003-3547-6634
FU Canadian Institute of Health Research Planning and Dissemination grant
   [33330]
FX Canadian Institute of Health Research Planning and Dissemination grant,
   Grant/Award Number: 33330
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NR 42
TC 9
Z9 10
U1 0
U2 12
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1740-8695
EI 1740-8709
J9 MATERN CHILD NUTR
JI Matern. Child Nutr.
PD JUL
PY 2020
VL 16
IS 3
AR e12947
DI 10.1111/mcn.12947
EA JAN 2020
PG 11
WC Nutrition & Dietetics; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics; Pediatrics
GA MB6EC
UT WOS:000506915000001
PM 31943785
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Longo-Mbenza, B
   Muaka, MM
   Masamba, W
   Kini, LM
   Phamba, IL
   Ndembe, DK
   Mona, DT
AF Longo-Mbenza, Benjamin
   Muaka, Moise Mvitu
   Masamba, Wayiza
   Kini, Lucien Muizila
   Phamba, Igor Longo
   Ndembe, Dalida Kibokela
   Mona, Doris Tulomba
TI Retinopathy in non diabetics, diabetic retinopathy and oxidative stress:
   a new phenotype in Central Africa?
SO INTERNATIONAL JOURNAL OF OPHTHALMOLOGY
LA English
DT Article
DE anticipation; apolipoprotein B; diabetic retinopathy; oxidative stress;
   discriminant analysis; Africa
ID ENDOTHELIAL DYSFUNCTION; SUPEROXIDE-DISMUTASE; ANTIOXIDANT ENZYMES;
   LIPID-PEROXIDATION; RISK-FACTORS; PLASMA; INFLAMMATION; PREVALENCE;
   PRODUCTS; PEOPLE
AB AIM: To evaluate the rates of retinopathy without diabetes and diabetic retinopathy (DR), associated with some markers of oxidative stress, antioxidants and cardiometabolic risk factors.
   METHODS: We determined the prevalence of DR in 150 type 2 diabetes mellitus (T2DM) patients, that of retinopathy in 50 non diabetics, the levels of body mass index (BMI), waist circumference (WC), blood pressure, lipids, 8 -isoprostane, 8 -hydroxydeoxyguanosine (8 - oHdG), gamma-glutamyl transferase (GGT), oxidized low density lipoprotein (LDL) (OxLDL), thiobarbituric acid reacting substances(TBARS), reduced glutathione (GSH), superoxide dismutase (SOD), uric acid, creatinine, albumin, total antioxidant status (TAOS), zinc, selenium, magnesium, vitamin C, vitamin D, vitamin E, glucose, apolipoprotein B (ApoB).
   RESULTS: The prevalences of DR at 53y and Rtp at 62y were 44% (n=66) and 10% (n=5), respectively. The highest levels of 8-isoprostane, 8-OHdG, TBARS, SOD, and OxLDL were in DR. The lowest levels of vitamin D, vitamin C, TAOS, and vitamin E were in DR. In the case-control study discriminant analysis, the levels of vitamin C, vitamin D, ApoB, 8-OHdG, creatinine, Zn, vitamin E, and WC distinguished significantly non-diabetics without DR (controls), T2DM patients without DR and T2DM patients with DR.
   CONCLUSION: Anticipation of DR onset is significantly associated with the exageration of oxidative stress biomarkers or decrease of antioxidants in African type 2 diabetics. Prevention of oxidative stress and abdominal obesity is needed. Supplementation in vitamin C, D, and E should be recommended as complement therapies of T2DM.
C1 [Longo-Mbenza, Benjamin] Walter Sisulu Univ, Fac Hlth Sci, ZA-5117 Mthatha, Eastern Cape, South Africa.
   [Muaka, Moise Mvitu] Univ Kinshasa, Dept Ophthalmol, Kinshasa 11, DEM REP CONGO.
   [Masamba, Wayiza] Walter Sisulu Univ, Dept Chem & Chem Technol, ZA-5117 Mthatha, Eastern Cape, South Africa.
   [Kini, Lucien Muizila] Walter Sisulu Univ, Umtata Gen Hosp, Dept Family Med, ZA-5117 Mthatha, Eastern Cape, South Africa.
   [Phamba, Igor Longo] Wendzou Med Coll, Sch Int Studies, Wenzhou 325005, Zhejiang, Peoples R China.
   [Ndembe, Dalida Kibokela] Univ Kinshasa, Dept Neuropsychiat, Kinshasa 11, DEM REP CONGO.
   [Mona, Doris Tulomba] Lomo Med Ctr, Biostat Unit, Kinshasa 11, DEM REP CONGO.
   [Mona, Doris Tulomba] Heart Africa Ctr Cardiol, Kinshasa 11, DEM REP CONGO.
C3 Walter Sisulu University; Universite de Kinshasa; Walter Sisulu
   University; Walter Sisulu University; Universite de Kinshasa
RP Longo-Mbenza, B (corresponding author), Walter Sisulu Univ, Fac Hlth Sci, Private Bag X1, ZA-5117 Mthatha, Eastern Cape, South Africa.
EM longombenza@gmail.com
RI Masamba, Wayiza/KEJ-6221-2024
OI Masamba, Wayiza/0000-0001-9024-6204
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NR 41
TC 19
Z9 20
U1 0
U2 13
PU IJO PRESS
PI XI AN
PA NO 269 YOUYI EAST RD, XI AN, 710054, PEOPLES R CHINA
SN 2222-3959
EI 2227-4898
J9 INT J OPHTHALMOL-CHI
JI Int. J. Ophthalmol.
PD APR 18
PY 2014
VL 7
IS 2
BP 293
EP 301
DI 10.3980/j.issn.2222-3959.2014.02.18
PG 9
WC Ophthalmology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Ophthalmology
GA AF4BI
UT WOS:000334656000018
PM 24790873
DA 2025-06-11
ER

PT J
AU Murri, M
   el Azzouzi, H
AF Murri, Mora
   el Azzouzi, Hamid
TI MicroRNAs as regulators of mitochondrial dysfunction and obesity
SO AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
LA English
DT Review
DE adipose tissue; microRNAs; mitochondrial dysfunction; obesity
ID MESENCHYMAL STEM-CELLS; BROWN ADIPOSE-TISSUE; ENHANCES ADIPOGENIC
   DIFFERENTIATION; DIET-INDUCED OBESITY; ADIPOCYTE DIFFERENTIATION;
   OXIDATIVE STRESS; SKELETAL-MUSCLE; TNF-ALPHA; INSULIN-RESISTANCE;
   METABOLIC SYNDROME
AB Obesity, which has become a major global epidemic, is associated with numerous comorbidities and nearly every chronic condition. Mitochondria play a central role in this disorder, as they control cell metabolism, regulating important processes, such as ATP production, lipid beta-oxidation, oxidative stress, and inflammation. MicroRNAs (miRs) have been shown to regulate many biological processes associated with obesity, comprising adipocyte differentiation, insulin action, and fat metabolism. In addition, recent studies have confirmed that miRs are important regulators of mitochondrial function by either directly modulating mitochondrial proteins or targeting mitochondrial regulators, thereby modulating metabolic process in the context of obesity. In this review, we describe the different roles of mitochondria in obesity, specifically in adipose tissue, and those miRs that are involved in mitochondrial dysfunction in this disease.
C1 [Murri, Mora; el Azzouzi, Hamid] Maastricht Univ, CARIM Sch Cardiovasc Dis, Dept Cardiol, Maastricht, Netherlands.
C3 Maastricht University
RP Murri, M (corresponding author), Maastricht Univ, Fac Hlth Med & Life Sci, Cardiol Dept, K-3-234,Univ Singel 50, NL-6229 ER Maastricht, Netherlands.
EM moramurri@gmail.com
OI Murri, Mora/0000-0002-6482-192X; el Azzouzi, Hamid/0000-0003-1242-9691
FU Netherlands CardioVascular Research Initiative; Dutch Heart Foundation;
   Dutch Federation of University Medical Centers; ZonMW; Royal Netherlands
   Academy of Sciences; ISCIII (Spain) [CP17/00133]
FX We acknowledge support from The Netherlands CardioVascular Research
   Initiative, the Dutch Heart Foundation, Dutch Federation of University
   Medical Centers, ZonMW, and the Royal Netherlands Academy of
   Sciences.CIBER Fisiopatologia de la Obesidad y Nutricion (CIBEROBN) is
   an ISCIII project. M. Murri is supported by a fellowship from ISCIII
   (Spain) ("Miguel Servet I" program, CP17/00133).
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NR 129
TC 26
Z9 27
U1 1
U2 14
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0363-6135
EI 1522-1539
J9 AM J PHYSIOL-HEART C
JI Am. J. Physiol.-Heart Circul. Physiol.
PD AUG
PY 2018
VL 315
IS 2
BP H291
EP H302
DI 10.1152/ajpheart.00691.2017
PG 12
WC Cardiac & Cardiovascular Systems; Physiology; Peripheral Vascular
   Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Physiology
GA GP8GA
UT WOS:000441147000011
PM 29652540
OA Bronze
DA 2025-06-11
ER

PT J
AU Banik, SD
   Avila-Nava, A
   Lugo, R
   Aké, RC
   Solis, ALG
AF Datta Banik, Sudip
   Avila-Nava, Azalia
   Lugo, Roberto
   Chim Ake, Rodolfo
   Gutierrez Solis, Ana Ligia
TI Association Between Low-Grade Inflammation and Hyperuricemia in Adults
   With Metabolic Syndrome in Yucatan, Mexico
SO CANADIAN JOURNAL OF DIABETES
LA English
DT Article
DE HOMA-IR; hs-CRP; hyperuricemia; IL-6; insulin resistance; metabolic
   syndrome; uric acid
ID C-REACTIVE PROTEIN; URIC-ACID; INSULIN-RESISTANCE; DIABETES-MELLITUS;
   OXIDATIVE STRESS; OBESITY; RISK; IL-6; INTERLEUKIN-6; HYPERTENSION
AB Background: Hyperuricemia (HUA) is commonly diagnosed among individuals with obesity, type 2 diabetes (T2D) and metabolic syndrome (MetS). Nevertheless, the association of HUA in individuals with MetS among the Mexican population is mostly unexplored. Low-grade inflammation has been postulated to have a key role in the pathogenesis of MetS and has been linked to insulin resistance (IR). However, it is uncertain whether HUA is associated with elevated levels of interleukin-6 and -10 (IL-6 and IL-10, respectively) and high-sensitivity C-reactive protein (hs-CRP) in individuals with MetS. Our main goal was to assess the values of inflammatory markers in a Mexican adult population without and with MetS and HUA.
   Methods: A cross-sectional study including 250 adults (77 men, 173 women) was carried out at a tertiary hospital in Merida, Yucatan, Mexico. Serum levels of IL-6, IL-10 and hs-CRP were evaluated by an enzyme-linked immunosorbent assay. The association between different conditions and inflammatory markers was analyzed using the point-biserial correlation (rpb) among patients.
   Results: IR was positively associated with higher levels of serum uric acid (SUA). Serum levels of IL-6 and hs-CRP were found to be significantly associated with MetS, HUA and combined clinical conditions of MetS and HUA in women. Inter-relationships were stronger in women than in men.
   Conclusions: An association between levels of IL-6 and hs-CRP in women with MetS and HUA was found. Therefore, screening and monitoring of SUA and these markers in patients with MetS may be an alternative for treatment of these metabolic conditions. (C) 2021 Canadian Diabetes Association.
C1 [Datta Banik, Sudip] Ctr Res & Adv Studies, Merida, Yucatan, Mexico.
   [Avila-Nava, Azalia; Lugo, Roberto; Chim Ake, Rodolfo; Gutierrez Solis, Ana Ligia] Reg High Special Hosp Yucatan Peninsula, Merida, Yucatan, Mexico.
RP Solis, ALG (corresponding author), Hosp Reg Alta Especialidad Peninsula Yucatan, Calle 7,433 20 & 22, Merida 97130, Yucatan, Mexico.
EM ganaligia@gmail.com
RI Datta Banik, Sudip/AAE-9929-2020
OI Avila-Nava, Azalia/0000-0003-3363-1477
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NR 46
TC 12
Z9 12
U1 1
U2 4
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1499-2671
EI 2352-3840
J9 CAN J DIABETES
JI Can. J. Diabetes
PD JUN
PY 2022
VL 46
IS 4
BP 369
EP 374
DI 10.1016/j.jcjd.2021.11.010
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 4Y6QA
UT WOS:000861649000007
PM 35484052
DA 2025-06-11
ER

PT J
AU Bahadoran, Z
   Golzarand, M
   Mirmiran, P
   Shiva, N
   Azizi, F
AF Bahadoran, Zahra
   Golzarand, Mahdieh
   Mirmiran, Parvin
   Shiva, Niloofar
   Azizi, Fereidoun
TI Dietary total antioxidant capacity and the occurrence of metabolic
   syndrome and its components after a 3-year follow-up in adults: Tehran
   Lipid and Glucose Study
SO NUTRITION & METABOLISM
LA English
DT Article
DE Dietary total antioxidant capacity; Antioxidant-rich foods; Metabolic
   syndrome
ID OXIDATIVE STRESS; RISK-FACTORS; RAT MODEL; SUPPLEMENTATION; ADIPOSITY;
   ASSOCIATION; POLYPHENOLS; POPULATION; EXPRESSION; SU.VI.MAX
AB Background: There is growing evidence that dietary antioxidants could have favorable effects on the attenuation and prevention of metabolic disorders. In the current study we investigated the association of dietary total antioxidant capacity (TAC) and metabolic syndrome (MetS) components and the occurrence of the MetS during a 3-year follow-up.
   Methods: This longitudinal study was conducted in the framework of Tehran Lipid and Glucose Study, between 2006-2008 and 2009-2011, on 1983 adults, aged 19-70 y. The usual intakes of participant were measured using a validated semi-quantitative food frequency questionnaire and dietary TAC was estimated at baseline. The MetS components were assessed at baseline and 3 years later. Multiple logistic regression models were used to estimate the occurrence of the MetS and its components according to dietary TAC quartile categories.
   Results: The mean age of participants was 40.4 +/- 13.0 y, and mean BMI was 27.03 +/- 4.9 kg/m(2) at baseline. After adjustment for potential confounding variables, TAC was associated with MetS components at baseline. Participant with highest TAC score had lower weight and abdominal fat gain during the 3 year follow-up. The chance of having the MetS, abdominal obesity and hypertension after 3 years decreased across the increasing dietary TAC quartile (P for trend < 0.01). Dietary TAC more than 1080 mu molTE/100 g of food, resulted in a 38% decrease in the risk of central obesity (OR = 0.62, 95% CI = 0.38-0.99).
   Conclusion: We demonstrated that higher dietary antioxidant intakes have favorable effects on metabolic disorders and, more interestingly, prevent subsequent weight and abdominal fat gain during a 3-year follow-up.
C1 [Bahadoran, Zahra; Golzarand, Mahdieh; Shiva, Niloofar] Shahid Beheshti Univ Med Sci, Res Inst Endocrine Sci, Nutr & Endocrine Res Ctr, Tehran 193954763, Iran.
   [Mirmiran, Parvin] Shahid Beheshti Univ Med Sci, Natl Nutr & Food Technol Res Inst, Fac Nutr Sci & Food Technol, Dept Clin Nutr & Dietet, Tehran 193954741, Iran.
   [Azizi, Fereidoun] Shahid Beheshti Univ Med Sci, Endocrine Res Ctr, Res Inst Endocrine Sci, Tehran 193954763, Iran.
C3 Shahid Beheshti University Medical Sciences; Shahid Beheshti University
   Medical Sciences; Shahid Beheshti University Medical Sciences
RP Mirmiran, P (corresponding author), Shahid Beheshti Univ Med Sci, Natl Nutr & Food Technol Res Inst, Fac Nutr Sci & Food Technol, Dept Clin Nutr & Dietet, 46 Arghavan E Gharbi St,Farahzadi Blv, Tehran 193954741, Iran.
EM mirmiran@endocrine.ac.ir
RI Bahadoran, Zahra/V-2003-2019; Mirmiran, Parvin/V-1433-2019; Azizi,
   Fereidoun/ABD-4136-2021; Golzarand, Mahdieh/E-4055-2018
OI Mirmiran, Parvin/0000-0003-2391-4924; Azizi,
   Fereidoun/0000-0002-6470-2517; Golzarand, Mahdieh/0000-0003-2651-9276
FU National Research Council of the Islamic Republic of Iran [121];
   Research Institute for Endocrine Sciences of Shahid Beheshti University
   of Medical Sciences
FX We thank the TLGS participants and the field investigators of the TLGS
   for their assistance in physical examinations, biochemical and
   nutritional evaluation and database management. This study was supported
   by grant 121 from National Research Council of the Islamic Republic of
   Iran and the Research Institute for Endocrine Sciences of Shahid
   Beheshti University of Medical Sciences.
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NR 32
TC 93
Z9 94
U1 0
U2 4
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1743-7075
J9 NUTR METAB
JI Nutr. Metab.
PD JUL 31
PY 2012
VL 9
AR 70
DI 10.1186/1743-7075-9-70
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 084JY
UT WOS:000314536400001
PM 22849424
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Jiménez-Morales, AI
   Ruano, J
   Delgado-Lista, J
   Fernandez, JM
   Camargo, A
   López-Segura, F
   Villarraso, JC
   Fuentes-Jiménez, F
   López-Miranda, J
   Pérez-Jiménez, F
AF Jimenez-Morales, Ana I.
   Ruano, Juan
   Delgado-Lista, Javier
   Fernandez, Juan M.
   Camargo, Antonio
   Lopez-Segura, Fernando
   Caballero Villarraso, Javier
   Fuentes-Jimenez, Francisco
   Lopez-Miranda, Jose
   Perez-Jimenez, Francisco
TI NOS3 Glu298Asp Polymorphism Interacts with Virgin Olive Oil Phenols to
   Determine the Postprandial Endothelial Function in Patients with the
   Metabolic Syndrome
SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Article
ID NITRIC-OXIDE SYNTHASE; CORONARY-ARTERY-DISEASE; GENE POLYMORPHISM;
   INTERNATIONAL-CONFERENCE; G894T POLYMORPHISM; CONSENSUS REPORT; COMMON
   VARIANT; RISK-FACTORS; ASSOCIATION; DYSFUNCTION
AB Background: Glu298Asp polymorphism of the endothelial nitric oxide synthase (eNOS) gene (NOS3) has been characterized as a risk factor of hypertension and coronary artery disease. Previous studies suggest that the higher risk observed in T allele carriers is due to endothelial dysfunction associated with a lower eNOS activity and that acute consumption of phenol-rich olive oil ameliorates postprandial endothelial dysfunction by reducing oxidative stress and increasing nitric oxide bioavailability. Nevertheless, how these facts may interact in a population with altered endothelial function such as metabolic syndrome patients remains unknown.
   Objective: The objective of the study was to evaluate whether the presence of NOS3 Glu298Asp polymorphism interacts with the phenol content of virgin olive oil (VOO) to influence postprandial endothelial function.
   Design: Fifty-seven subjects with metabolic syndrome received three breakfasts based on VOO with different phenolic content. Baseline, incremental area under the curve, peak, and maximum parameters of postocclusive skin reactive hyperemia (PORH) were evaluated by laser Doppler, and the nitrate/nitrite [NO(x)] and eNOS concentrations were obtained during fasting and postprandially.
   Results: A gene-diet interaction was found on maximum PORH and NO(x) (P = 0.039 and P = 0.043, respectively). TT subjects showed lower values of eNOS, NO(x), and maximum PORH as compared with GG and GT subjects, especially in the postprandial measurements (all P < 0.05). However, most of these differences were attenuated when high-phenol VOO was consumed.
   Conclusion: In a population with a compromised endothelial function, concentrations of phenols in dietary VOO interact with NOS3 Glu298Asp to ameliorate the endothelial dysfunction associated to the TT genotype. (J Clin Endocrinol Metab 96: E1694-E1702, 2011)
C1 [Perez-Jimenez, Francisco] Univ Cordoba, Hosp Univ Reina Sofia, Med Interna Serv,Lipids & Atherosclerosis Unit, Inst Maimonides Invest Biomed Cordoba, E-14004 Cordoba, Spain.
   [Caballero Villarraso, Javier] Reina Sofia Univ Hosp, Inst Salud Carlos III, Ctr Invest Biomed Red Fisiopatol Obesidad & Nutr, Cordoba 14004, Spain.
   [Caballero Villarraso, Javier] Reina Sofia Univ Hosp, Biochem Lab, Cordoba 14004, Spain.
C3 Universidad de Cordoba; Hospital Universitario Reina Sofia - Cordoba;
   Hospital Universitario Reina Sofia - Cordoba; CIBER - Centro de
   Investigacion Biomedica en Red; CIBEROBN; Instituto de Salud Carlos III;
   Hospital Universitario Reina Sofia - Cordoba
RP Pérez-Jiménez, F (corresponding author), Univ Cordoba, Hosp Univ Reina Sofia, Med Interna Serv,Lipids & Atherosclerosis Unit, Inst Maimonides Invest Biomed Cordoba, Ave Menendez Pidal S-N, E-14004 Cordoba, Spain.
EM fperezjimenez@uco.es
RI Fernandez, Juan/AAE-9556-2020; Fuentes-Jimenez, Francisco
   Jose/HTM-0138-2023; Ruano, Juan/T-1991-2018; Jimenez,
   Francisco/AAJ-9559-2021; Delgado-Lista, Javier/KAM-7412-2024;
   Lopez-Miranda, Jose/Y-8306-2019; Caballero-Villarraso,
   Javier/AAC-3434-2019; FUENTES JIMENEZ, FRANCISCO/G-4311-2016; Camargo
   Garcia, Antonio/G-9720-2015
OI Caballero-Villarraso, Javier/0000-0003-0571-5147; Ruano,
   Juan/0000-0002-0286-4107; Perez-Jimenez, Francisco/0000-0001-7499-7681;
   FUENTES JIMENEZ, FRANCISCO/0000-0002-4584-7366; Perez Jimenez,
   Francisco/0000-0001-9808-1280; Camargo Garcia,
   Antonio/0000-0002-0415-4184; Lopez-Miranda, Jose/0000-0002-8844-0718;
   Delgado Lista, Francisco Javier/0000-0002-2982-2716
FU Consejeria de Economia, Innovacion y Ciencia [AGR 922]; Junta de
   Andalucia; Consejeria de Salud, Junta de Andalucia [06/0129, 0040/07];
   Centro de Excelencia en Investigacion sobre Aceite de Oliva y Salud [REF
   200500253]; Diputacion Provincial de Cordoba; Agencia para el Aceite de
   Oliva and the University of Cordoba; Spanish Ministry of Health
   [CB06/03/0047]; Centro de Investigacion Biomedica en Red Fisiopatologia
   de la Obesidad y Nutricion, Instituto de Salud Carlos III; Fundacion
   Biomedica de Cordoba
FX This work was supported by Grant AGR 922 from the Consejeria de
   Economia, Innovacion y Ciencia, Junta de Andalucia (to F.P.-J.); Grants
   06/0129 (to F.P.-J.) and 0040/07 (to J.R.) from the Consejeria de Salud,
   Junta de Andalucia; Grant REF 200500253 from the Centro de Excelencia en
   Investigacion sobre Aceite de Oliva y Salud (to F.P.-J.); and the
   Diputacion Provincial de Cordoba, Agencia para el Aceite de Oliva and
   the University of Cordoba. The work was also supported in part by
   research grants from the Spanish Ministry of Health (Grant CB06/03/0047,
   Centro de Investigacion Biomedica en Red Fisiopatologia de la Obesidad y
   Nutricion, Instituto de Salud Carlos III, to F.P.-J.) and the Fundacion
   Biomedica de Cordoba.
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NR 42
TC 22
Z9 23
U1 0
U2 5
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0021-972X
EI 1945-7197
J9 J CLIN ENDOCR METAB
JI J. Clin. Endocrinol. Metab.
PD OCT
PY 2011
VL 96
IS 10
BP E1694
EP E1702
DI 10.1210/jc.2011-1056
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 833JC
UT WOS:000295879600021
PM 21816783
OA Bronze
DA 2025-06-11
ER

PT J
AU Beckmann, S
   Denhaerynck, K
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AF Beckmann, Sonja
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CA Psychosocial Interest Grp
   Swiss Transplant Cohort Study
TI New-onset obesity after liver transplantation-outcomes and risk factors:
   the Swiss Transplant Cohort Study
SO TRANSPLANT INTERNATIONAL
LA English
DT Article
DE alcoholic liver disease; cardiovascular; genetics; obesity; survival
ID WEIGHT-GAIN; METABOLIC SYNDROME; TERM; GRAFT; DEPRESSION; SURVIVAL;
   PATIENT; ANXIETY
AB Weight gain after liver transplantation (LTx) facilitates development of new-onset obesity; however, its risk factors and outcomes are poorly understood. We identified the impact of new-onset obesity on cardiovascular events (CVEs) and patient survival, and risk factors for new-onset obesity. Multiple Cox regression models examined risk factors for CVEs, patient survival, and new-onset obesity in 253 adults (mean age 52.2 +/- 11.6 years, male gender 63.6%, mean follow up 5.7 +/- 2.1 years). Cumulative incidence of post-LTx CVE was 28.1%; that of new-onset obesity was 21.3%. Regardless of CVE at LTx, post-LTx CVEs were predicted by new-onset obesity [Hazard Ratio (HR), 2.95; P = 0.002] and higher age at LTx (HR, 1.05; P < 0.001). In patients without known pre-LTx CVEs (n = 214), risk factors for post-LTx CVEs were new-onset obesity (HR, 2.59; P = 0.014) and higher age (HR, 1.04; P = 0.001). Survival was not associated with new-onset obesity (P = 0.696). Alcoholic liver disease predicted new-onset obesity (HR, 3.37; P = 0.025), female gender was protective (HR, 0.39; P = 0.034). In 114 patients with available genetic data, alcoholic liver disease (HR, 12.82; P = 0.014) and hepatocellular carcinoma (HR, 10.02; P = 0.048) predicted new-onset obesity, and genetics remained borderline significant (HR, 1.07; P = 0.071). Early introduction of post-LTx weight management programs may suggest a potential pathway to reduce CVE risk.
C1 [Beckmann, Sonja; Denhaerynck, Kris; De Geest, Sabina] Univ Basel, Inst Nursing Sci, Basel, Switzerland.
   [Beckmann, Sonja] Univ Hosp Zurich, Ctr Clin Nursing Sci, Zurich, Switzerland.
   [Stampf, Susanne] Univ Hosp Basel, Clin Transplantat Immunol & Nephrol Swiss Transpl, Basel, Switzerland.
   [Saigi-Morgui, Nuria] Lausanne Univ Hosp, Unit Pharmacogenet & Clin Psychopharmacol, Dept Psychiat, Ctr Psychiat Neurosci, Prilly, Switzerland.
   [Binet, Isabelle] Cantonal Hosp St Gallen, Nephrol & Transplantat Med, St Gallen, Switzerland.
   [Koller, Michael] Basel Inst Clin Epidemiol & Biostat, Basel, Switzerland.
   [Boely, Elsa] Univ Hosp Geneva, Geneva, Switzerland.
   [De Geest, Sabina] Katholieke Univ Leuven, Dept Publ Hlth & Primary Care, Acad Ctr Nursing & Midwifery, Leuven, Belgium.
C3 University of Basel; University of Zurich; University Zurich Hospital;
   University of Basel; Kantonsspital St. Gallen; Swiss School of Public
   Health (SSPH+); University of Geneva; KU Leuven
RP De Geest, S (corresponding author), Univ Basel, Dept Publ Hlth, Inst Nursing Sci, Bernoullistr 28, CH-4056 Basel, Switzerland.
EM sabina.degeest@unibas.ch
RI De Geest, Sabina/F-7724-2010; Koller, Michael/AEN-1656-2022; Toso,
   Christian/E-7785-2018; Hofbauer, Gunther/B-2671-2010; Mullhaupt,
   Beat/O-3744-2016
OI Schaub, Stefan/0000-0002-9170-1341; STCS, Swiss Transplant Cohort
   Study/0000-0002-6369-819X; Saigi, Nuria/0000-0003-2503-1818; Hirsch,
   Hans H./0000-0003-0883-0423; Berben, Lut/0000-0003-3912-6826; Benden,
   Christian/0000-0002-8409-5646; Toso, Christian/0000-0003-1652-4522;
   huynh-do, uyen/0000-0002-7276-032X; Kunzler-Heule,
   Patrizia/0000-0003-0576-749X; Leppla, Lynn/0000-0003-0233-7304; Passweg,
   Jakob R/0000-0001-7092-3351; Hofbauer, Gunther/0000-0003-0542-7989;
   Elkrief, Laure/0000-0003-2843-1710; Mullhaupt, Beat/0000-0002-9020-8192;
   DE GEEST, SABINA/0000-0001-6596-7237
FU Swiss National Science Foundation STCS Grant [134267]
FX This work was supported by the Swiss National Science Foundation STCS
   Grant (Grant number 134267).
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NR 44
TC 16
Z9 17
U1 0
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0934-0874
EI 1432-2277
J9 TRANSPL INT
JI Transpl. Int.
PD NOV
PY 2018
VL 31
IS 11
BP 1254
EP 1267
DI 10.1111/tri.13308
PG 14
WC Surgery; Transplantation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery; Transplantation
GA GW7QI
UT WOS:000447163400009
PM 29984844
OA Bronze
DA 2025-06-11
ER

PT J
AU Cheon, SY
   Kim, H
   Rubinsztein, DC
   Lee, JE
AF Cheon, So Yeong
   Kim, Hyunjeong
   Rubinsztein, David C.
   Lee, Jong Eun
TI Autophagy, Cellular Aging and Age-related Human Diseases
SO EXPERIMENTAL NEUROBIOLOGY
LA English
DT Review
DE Autophagy; Aging; DNA damage; Oxidative stress; Telomere shortening;
   SASP
ID AMYOTROPHIC-LATERAL-SCLEROSIS; STARVATION-INDUCED AUTOPHAGY; BASE
   EXCISION-REPAIR; OXIDATIVE STRESS; DNA-DAMAGE; A-BETA;
   ALZHEIMERS-DISEASE; MOUSE MODEL; CHROMOSOMAL INSTABILITY;
   MITOCHONDRIAL-FUNCTION
AB Macroautophagy/autophagy is a conserved degradation system that engulfs intracytoplasmic contents, including aggregated proteins and organelles, which is crucial for cellular homeostasis. During aging, cellular factors suggested as the cause of aging have been reported to be associated with progressively compromised autophagy. Dysfunctional autophagy may contribute to age-related diseases, such as neurodegenerative disease, cancer, and metabolic syndrome, in the elderly. Therefore, restoration of impaired autophagy to normal may help to prevent age-related disease and extend lifespan and longevity. Therefore, this review aims to provide an overview of the mechanisms of autophagy underlying cellular aging and the consequent disease. Understanding the mechanisms of autophagy may provide potential information to aid therapeutic interventions in age-related diseases.
C1 [Cheon, So Yeong; Kim, Hyunjeong; Rubinsztein, David C.] Univ Cambridge, CIMR, Dept Med Genet, Cambridge CB2 0XY, England.
   [Cheon, So Yeong; Kim, Hyunjeong; Lee, Jong Eun] Yonsei Univ, Dept Anat, Coll Med, Seoul 03722, South Korea.
   [Rubinsztein, David C.] Univ Cambridge, UK Dementia Res Inst, Cambridge CB2 0AH, England.
   [Lee, Jong Eun] Yonsei Univ, Coll Med, BK21 Plus Project Med Sci, Seoul 03722, South Korea.
   [Lee, Jong Eun] Yonsei Univ, Coll Med, Brain Res Inst, Seoul 03722, South Korea.
C3 University of Cambridge; Yonsei University; Yonsei University Health
   System; University of Cambridge; Yonsei University; Yonsei University
   Health System; Yonsei University; Yonsei University Health System
RP Rubinsztein, DC (corresponding author), Univ Cambridge, CIMR, Dept Med Genet, Cambridge CB2 0XY, England.; Lee, JE (corresponding author), Yonsei Univ, Dept Anat, Coll Med, Seoul 03722, South Korea.; Rubinsztein, DC (corresponding author), Univ Cambridge, UK Dementia Res Inst, Cambridge CB2 0AH, England.; Lee, JE (corresponding author), Yonsei Univ, Coll Med, BK21 Plus Project Med Sci, Seoul 03722, South Korea.; Lee, JE (corresponding author), Yonsei Univ, Coll Med, Brain Res Inst, Seoul 03722, South Korea.
EM dcr1000@cam.ac.uk; jelee@yuhs.ac
RI Lee, Joo Yong/ADE-2110-2022; Rubinsztein, David/C-3472-2011; Cheon, So
   Yeong/AER-6628-2022
OI Cheon, So Yeong/0000-0001-7015-4898; Lee, Jong Eun/0000-0001-6203-7413
FU UK Dementia Research Institute (MRC); UK Dementia Research Institute
   (Alzheimer's Research UK); UK Dementia Research Institute (Alzheimer's
   Society); Roger de Spoelberch Foundation; Alzheimer's Research UK; Tau
   Consortium; Cambridge Centre for Parkinson-Plus; National Institute for
   Health Research Cambridge Biomedical Research Centre; Korea Health
   Technology R&D Project through the Korea Health Industry Development
   Institute - Ministry of Health & Welfare, Republic of Korea [HI14C2173];
   MRC [UKDRI-2002] Funding Source: UKRI
FX We are grateful for funding from the UK Dementia Research Institute
   (funded by the MRC, Alzheimer's Research UK and the Alzheimer's
   Society), Roger de Spoelberch Foundation, Alzheimer's Research UK, The
   Tau Consortium, Cambridge Centre for Parkinson-Plus, National Institute
   for Health Research Cambridge Biomedical Research Centre (D. C. R.), and
   the Korea Health Technology R&D Project (HI14C2173) through the Korea
   Health Industry Development Institute, funded by the Ministry of Health
   & Welfare, Republic of Korea (S.Y.C., H. K., and J.E.L). The views
   expressed are those of the author(s) and not necessarily those of the
   NHS, the NIHR or the Department of Health and Social Care.
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NR 167
TC 58
Z9 63
U1 0
U2 27
PU KOREAN SOC BRAIN & NEURAL SCIENCE, KOREAN SOC NEURODEGENERATIVE DISEASE
PI SEOUL
PA EXPERIMENTAL NEUROBIOLOGY,  SEOUL NATL UNIV, RM 410, BLDG 152-1, SEOUL,
   151-742, SOUTH KOREA
SN 1226-2560
EI 2093-8144
J9 EXP NEUROBIOL
JI Exp. Neurobiol.
PD NOV
PY 2019
VL 28
IS 6
BP 643
EP 657
DI 10.5607/en.2019.28.6.643
PG 15
WC Medicine, Research & Experimental; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Neurosciences & Neurology
GA KA4YR
UT WOS:000505803500001
PM 31902153
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Nguyen, CQ
   Pham, TTP
   Phan, DC
   Do, HT
   Mizoue, T
   Inoue, Y
AF Nguyen, Chau Que
   Pham, Thuy Thi Phuong
   Phan, Danh Cong
   Do, Hung Thai
   Mizoue, Tetsuya
   Inoue, Yosuke
TI Cohort profile of a prospective cohort study among middle-aged
   community-dwellers in rural Vietnam: The Khánh Hòa cardiovascular study
SO PLOS ONE
LA English
DT Article
ID PHYSICAL-ACTIVITY; RISK-FACTORS; HYPERTENSION; DISEASE; INFLAMMATION;
   METAANALYSIS; ASSOCIATION; SMOKING; BURDEN
AB Disease burden associated with cardiovascular diseases (CVDs) in low- and middle-income countries has been on an increasing trend in the past decades. Despite the worldwide genetic, cultural, and environmental variations in determinants of CVDs, few studies have attempted the identification of risk factors of CVDs in low- and middle-income countries. This article aims to introduce the Kh & aacute;nh H & ograve;a Cardiovascular Study, a prospective cohort study among middle-aged community dwellers in rural Kh & aacute;nh H & ograve;a, Vietnam. A total of 3000 individuals, aged 40-60 years at baseline, participated in the baseline survey conducted from June 2019 to June 2020 and will be followed up for the subsequent 10 years. The baseline survey collected information on sociodemographic variables, disease history, lifestyle, social environment, and mental health via questionnaires, physical examinations, and biochemical measurements. Information on the incidence of severe health outcomes (i.e., mortality, CVDs, and cancer) has been and will be collected using a study-specific disease registry. Results showed that the prevalences of excess body weight (body mass index >= 25 kg/m2), hypertension, diabetes mellitus, and dyslipidemia were 25.9%, 39.6%, 10.2%, and 45.1%, respectively. Furthermore, by March 2023, 21 participants had died, including 5 CVD deaths and 12 cancer deaths. Moreover, we recorded 22 and 31 cases of nonfatal CVDs and cancer, respectively. These results suggest that many rural residents in Vietnam have high cardiometabolic risk, and underscore the importance of advancing research to identify risk factors and prevent the onset of serious health events.
C1 [Nguyen, Chau Que; Pham, Thuy Thi Phuong; Phan, Danh Cong] Pasteur Inst Nha Trang, Dept Noncommunicable Dis Control & Nutr, Nha Trang, Khanh Hoa, Vietnam.
   [Do, Hung Thai] Pasteur Inst Nha Trang, Nha Trang, Khanh Hoa, Vietnam.
   [Mizoue, Tetsuya; Inoue, Yosuke] Natl Ctr Global Hlth & Med, Dept Epidemiol & Prevent, Tokyo, Japan.
C3 Japan Institute for Health Security (JIHS); National Center for Global
   Health & Medicine - Japan
RP Inoue, Y (corresponding author), Natl Ctr Global Hlth & Med, Dept Epidemiol & Prevent, Tokyo, Japan.
EM yosuke.yoshi.yosky@gmail.com
OI Inoue, Yosuke/0000-0002-7690-3447
FU National Center for Global Health and Medicine [19A06, 22A02]; Pfizer
   Health Research Foundation; Japan Society for the Promotion of Science
   (KAKANHI) [JP19K20536, JP23H03638, JP21J01171, JP21K17301]
FX This work was supported by The National Center for Global Health and
   Medicine (19A06, 22A02 awarded to YI), The Pfizer Health Research
   Foundation (awarded to YI), and The Japan Society for the Promotion of
   Science (KAKANHI) (JP19K20536, JP23H03638 awarded to YI, JP21J01171
   awarded to Aki Yazawa, JP21K17301 awarded to Dong Van Hoang). The
   funders had no role in study design, data collection and analysis,
   decision to publish, or preparation of the manuscript. Aki Yazawa and
   Dong Van Hoang did not contribute specifically to this work, but we have
   used the research grants awarded to them to manage the cohort.
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NR 52
TC 2
Z9 2
U1 0
U2 0
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD DEC 3
PY 2024
VL 19
IS 12
AR e0312525
DI 10.1371/journal.pone.0312525
PG 15
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA O8X5O
UT WOS:001373890800074
PM 39625885
OA gold
DA 2025-06-11
ER

PT J
AU Park, J
   Kim, J
   Shin, DW
   Shin, J
   Cho, B
   Song, YM
AF Park, Junhee
   Kim, Jiyoung
   Shin, Dong Wook
   Shin, Jinyoung
   Cho, Belong
   Song, Yun-Mi
TI Factors Associated with Dietary Habit Changes in Korean Stomach Cancer
   Survivors after Cancer Treatment
SO NUTRIENTS
LA English
DT Article
DE stomach cancer survivor; dietary habit change; nutritional guidelines
ID GASTRIC-CANCER; METABOLIC SYNDROME; PHYSICAL-ACTIVITY; RISK;
   METAANALYSIS; CONSUMPTION; NUTRITION; FRUIT; FEAR
AB The current nutritional guidelines for stomach cancer survivors (SCSs) mainly focus on the influence of the surgical resection of the stomach, with limited guidance regarding a wider range of food options. We aimed to investigate the factors associated with healthier dietary changes in Korean adult SCSs. This cross-sectional study assessed dietary pattern changes after cancer treatment for 11 food categories, using a self-administered questionnaire. A 'healthier dietary change' was operationally defined as a reduced consumption of red and processed meat, grains, salt, and burnt food, and an increased consumption of poultry, fish, vegetables, fruits, legumes, and dairy products. Among a total of 624 SCSs, approximately 60% of participants reported dietary changes in a healthier direction in three or more food categories, while 9.1% reported no changes. There was no significant difference in dietary habit changes between surgery types. Multivariable adjusted analysis showed that elderly and long-term survivors were inversely associated with a healthier dietary change. SCSs with a higher level of educational achievement and income were more likely to make healthier changes in their intake of processed meat, vegetables, fruits, burnt food, or salt. SCSs with higher levels of fear of cancer recurrence, anxiety, or depression were more likely to follow healthier dietary changes regarding fish, meat, fruits, grains, or burnt food. Change in dietary pattern varied across different food items, and was associated with various characteristics of SCSs. It is crucial to repeatedly provide SCSs with information about healthier dietary patterns, considering their sociodemographic, clinical, and psychological characteristics.
C1 [Park, Junhee; Shin, Dong Wook; Song, Yun-Mi] Sungkyunkwan Univ, Samsung Med Ctr, Dept Family Med, Sch Med, Seoul 06351, South Korea.
   [Park, Junhee; Shin, Dong Wook; Song, Yun-Mi] Sungkyunkwan Univ, Support Care Ctr, Samsung Med Ctr, Sch Med, Seoul 06351, South Korea.
   [Kim, Jiyoung; Cho, Belong] Seoul Natl Univ Hosp, Dept Family Med, Seoul 03080, South Korea.
   [Kim, Jiyoung; Cho, Belong] Seoul Natl Univ Hosp, Hlth Promot Ctr, Seoul 03080, South Korea.
   [Shin, Dong Wook] Sungkyunkwan Univ, Samsung Adv Inst Hlth Sci & Technol, Dept Clin Res Design & Evaluat, Seoul 06355, South Korea.
   [Shin, Jinyoung] Konkuk Univ, Dept Family Med, Med Ctr, Seoul 05030, South Korea.
C3 Sungkyunkwan University (SKKU); Samsung Medical Center; Sungkyunkwan
   University (SKKU); Samsung Medical Center; Seoul National University
   (SNU); Seoul National University Hospital; Seoul National University
   (SNU); Seoul National University Hospital; Sungkyunkwan University
   (SKKU); Samsung Medical Center; Konkuk University; Konkuk University
   Medical Center
RP Song, YM (corresponding author), Sungkyunkwan Univ, Samsung Med Ctr, Dept Family Med, Sch Med, Seoul 06351, South Korea.
EM junhee.park26@gmail.com; a7071@snuh.org; dwshin.md@gmail.com;
   jyshin@kuh.ac.kr; belong.cho@gmail.com; yunmisong@skku.edu
RI Park, Jinkyeong/GLV-1674-2022; Cho, Belong/GLU-3443-2022; Kim,
   Seong-Gon/AAF-7553-2020; Shin, Dong Wook/J-6721-2016
OI Shin, Jinyoung/0000-0001-9558-1853; Kim, Jiyoung/0000-0002-6739-3545;
   PARK, JUNHEE/0000-0003-3780-6844; Shin, Dong Wook/0000-0001-8128-8920
FU Basic Science Research Program through the National Research Foundation
   of Korea (NRF) - Ministry of Science, ICT and Future Planning
   [2014R1A2A2A01002705]
FX This research was supported by Basic Science Research Program through
   the National Research Foundation of Korea (NRF), funded by the Ministry
   of Science, ICT and Future Planning (2014R1A2A2A01002705). The funding
   source had no involvement in the study design, data collection, data
   analysis, or data interpretation.
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NR 54
TC 2
Z9 2
U1 3
U2 8
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JUL
PY 2023
VL 15
IS 14
AR 3268
DI 10.3390/nu15143268
PG 14
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA N3UI6
UT WOS:001036298800001
PM 37513686
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Raherison, C
   Ouaalaya, E
   Bernady, A
   Casteigt, J
   Nocent-Eijnani, C
   Falque, L
   Le Guillou, F
   Nguyen, L
   Ozier, A
   Molimard, M
AF Raherison, Chantal
   Ouaalaya, El-Hassane
   Bernady, Alain
   Casteigt, Julien
   Nocent-Eijnani, Cecilia
   Falque, Laurent
   Le Guillou, Frederic
   Nguyen, Laurent
   Ozier, Annaig
   Molimard, Mathieu
TI Comorbidities and COPD severity in a clinic-based cohort
SO BMC PULMONARY MEDICINE
LA English
DT Article
DE COPD; Comorbidities; Cluster analysis; Management
ID OBSTRUCTIVE PULMONARY-DISEASE; SLEEP-APNEA; MORTALITY
AB Background: Chronic obstructive pulmonary disease (COPD) is an important cause of morbidity and mortality around the world. The aim of our study was to determine the association between specific comorbidities and COPD severity.
   Methods: Pulmonologists included patients with COPD using a web-site questionnaire. Diagnosis of COPD was made using spirometry post-bronchodilator FEV1/FVC < 70%. The questionnaire included the following domains: demographic criteria, clinical symptoms, functional tests, comorbidities and therapeutic management. COPD severity was classified according to GOLD 2011. First we performed a principal component analysis and a non-hierarchical cluster analysis to describe the cluster of comorbidities.
   Results: One thousand, five hundred and eighty-four patients were included in the cohort during the first 2 years. The distribution of COPD severity was: 27.4% in group A, 24.7% in group B, 11.2% in group C, and 36.6% in group D. The mean age was 66.5 (sd: 11), with 35% of women. Management of COPD differed according to the comorbidities, with the same level of severity. Only 28.4% of patients had no comorbidities associated with COPD. The proportion of patients with two comorbidities was significantly higher (p < 0.001) in GOLD B (50.4%) and D patients (53.1%) than in GOLD A (35.4%) and GOLD C ones (34.3%). The cluster analysis showed five phenotypes of comorbidities: cluster 1 included cardiac profile; cluster 2 included less comorbidities; cluster 3 included metabolic syndrome, apnea and anxiety-depression; cluster 4 included denutrition and osteoporosis and cluster 5 included bronchiectasis. The clusters were mostly significantly associated with symptomatic patients i.e. GOLD B and GOLD D.
   Conclusions: This study in a large real-life cohort shows that multimorbidity is common in patients with COPD.
C1 [Raherison, Chantal; Ouaalaya, El-Hassane] Univ Bordeaux, Bordeaux Populat Hlth Res Ctr, INSERM, Team EPICENE,UMR 1219, F-33000 Bordeaux, France.
   [Raherison, Chantal] CHU Bordeaux, Resp Dis Dept, Pole Cardiothorac, F-33000 Bordeaux, France.
   [Bernady, Alain] Rehabil Ctr, Cambo Les Bains, France.
   [Casteigt, Julien] Pneumol Clin, St Medard En Jalles, France.
   [Nocent-Eijnani, Cecilia] Gen Hosp, Bayonne, France.
   [Falque, Laurent] Pneumol Clin, Bordeaux, France.
   [Le Guillou, Frederic] Pneumol Clin, La Rochelle, France.
   [Nguyen, Laurent; Ozier, Annaig] Pneumol Clin, Bordeaux, Germany.
   [Molimard, Mathieu] Bordeaux Univ, Pharmacoepidemiol U1219, Bordeaux, France.
   [Raherison, Chantal] Univ Bordeaux, INSERM, Bordeaux Populat Hlth Res Ctr, Team EPICENE,UMR 1219, 146 Rue Leo Saignat, F-33076 Bordeaux, France.
C3 Institut National de la Sante et de la Recherche Medicale (Inserm);
   Universite de Bordeaux; CHU Bordeaux; Universite de Bordeaux; Universite
   de Bordeaux; Institut National de la Sante et de la Recherche Medicale
   (Inserm)
RP Raherison, C (corresponding author), Univ Bordeaux, Bordeaux Populat Hlth Res Ctr, INSERM, Team EPICENE,UMR 1219, F-33000 Bordeaux, France.; Raherison, C (corresponding author), CHU Bordeaux, Resp Dis Dept, Pole Cardiothorac, F-33000 Bordeaux, France.; Raherison, C (corresponding author), Univ Bordeaux, INSERM, Bordeaux Populat Hlth Res Ctr, Team EPICENE,UMR 1219, 146 Rue Leo Saignat, F-33076 Bordeaux, France.
EM Chantal.raherison@chu-bordeaux.fr
RI OUAALAYA, El/T-4560-2019; Raherison, Chantal/T-3556-2019; molimard,
   mathieu/T-2762-2019
OI ouaalaya, El-hassane/0000-0001-6584-4632; Molimard,
   Mathieu/0000-0002-4346-8346
FU Bordeaux University Foundation; Novartis Pharma; Isis Medical;
   Boehringer Ingelheim; Glaxo-Smith Kline
FX Funding (unrestricted grants): Bordeaux University Foundation, Novartis
   Pharma, Isis Medical, Boehringer Ingelheim, Glaxo-Smith Kline. The
   funding sources had no role in the design or conduct of the study, in
   the collection, management, analysis and interpretation of the data, or
   in the preparation, review or approval of the manuscript.
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NR 18
TC 39
Z9 43
U1 0
U2 11
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1471-2466
J9 BMC PULM MED
JI BMC Pulm. Med.
PD JUL 16
PY 2018
VL 18
AR 117
DI 10.1186/s12890-018-0684-7
PG 10
WC Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Respiratory System
GA GN4DC
UT WOS:000438964500001
PM 30012144
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Patel, PN
   Pathak, R
AF Patel, Priti N.
   Pathak, Rolee
TI Rimonabant: A novel selective cannabinoid-1 receptor antagonist for
   treatment of obesity
SO AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY
LA English
DT Article
DE anorexics; dosage; drug administration; drug interactions; duration of
   action; mechanism of action; obesity; pharmacodynamics;
   pharmacokinetics; rimonabant; toxicity
ID RISK-FACTORS; OVERWEIGHT PATIENTS; WEIGHT; PHARMACOKINETICS; ORLISTAT;
   BLOCKER
AB Purpose. The pharmacology, pharmacokinetics, clinical efficacy, safety, drug interactions, and dosage and administration of rimonabant in the treatment of obesity and related metabolic factors are reviewed. Summary. Discovery of the cannabinoid receptors has led to the development of rimonabant, a cannabinoid-1 (CB1) antagonist. Selective blockade of this receptor has been shown to lead to decreased appetite and food intake in animal models. Clinical studies have shown that rimonabant 20;mg once daily produces significant decreases in weight and waist circumference in obese human subjects and improves the lipid profile and glucose control. The frequency of metabolic syndrome also decreased significantly with rimonabant 20 mg daily. Limited data are available regarding the pharmacokinetics and pharmacodynamics of rimonabant. Preclinical data have demonstrated a long duration of action. As of yet, no drug-drug, drug-food, or drug-disease interactions have been identified with rimonabant. Adverse reactions occurred rarely, with nausea, dizziness, diarrhea, arthralgia, and back pain being the most common. Psychiatric disorders, including depression and anxiety, were the most common reasons for subjects to withdraw from rimonabant studies. Rimonabant has been shown to be safe for up to two years of treatment. Further research will clarify currently unknown areas, including pharmacokinetics, drug interactions, and the drug's role in standard therapy.
   Conclusion. Rimonabant, a selective CB1 antagonist, is a novel treatment option for obese and overweight individuals. Significant weight loss, decrease in waist circumference, and improvements in lipid profile and glucose control have been shown in clinical trials of rimonabant.
C1 St Johns Univ, Coll Pharm & Allied Hlth Profess, Queens, NY 11439 USA.
   St Johns Univ, Drug Informat Ctr, Queens, NY 11439 USA.
   Rutgers State Univ, Ernest Mario Coll Pharm, Piscataway, NJ USA.
   Englewood Hosp & Med Ctr, Englewood, NJ USA.
C3 Saint John's University; Saint John's University; Rutgers University
   System; Rutgers University New Brunswick; Englewood Hospital & Medical
   Center
RP Patel, PN (corresponding author), St Johns Univ, Coll Pharm & Allied Hlth Profess, St Albert Hall,Room 114,8000 Utopia Pkwy, Queens, NY 11439 USA.
EM patelp2@stjohns.edu
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NR 38
TC 45
Z9 45
U1 1
U2 13
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1079-2082
EI 1535-2900
J9 AM J HEALTH-SYST PH
JI Am. J. Health-Syst. Pharm.
PD MAR 1
PY 2007
VL 64
IS 5
BP 481
EP 489
DI 10.2146/060258
PG 9
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 145PZ
UT WOS:000244878300009
PM 17322160
DA 2025-06-11
ER

PT J
AU Rochette, L
   Zeller, M
   Cottin, Y
   Vergely, C
AF Rochette, Luc
   Zeller, Marianne
   Cottin, Yves
   Vergely, Catherine
TI Redox Functions of Heme Oxygenase-1 and Biliverdin Reductase in Diabetes
SO TRENDS IN ENDOCRINOLOGY AND METABOLISM
LA English
DT Review
ID NF-KAPPA-B; OXIDATIVE STRESS; CARBON-MONOXIDE; NITRIC-OXIDE; METABOLIC
   SYNDROME; HEPATIC STEATOSIS; GILBERTS-SYNDROME; SERINE 73; BILIRUBIN;
   INFLAMMATION
AB In patients with diabetes, the hyperglycemia-driven excess generation of reactive oxygen species (ROS) induces oxidative stress (OS) in a variety of tissues. OS is closely associated with chronic inflammation and has a key role in the pathogenesis of vascular complications. The enzymes that generate ROS and gasotransmitters are redox regulated and are implicated in cellular signaling. As a result of cellular metabolism, cells produce significant amounts of carbon monoxide (CO), mainly from heme degradation catalyzed by heme oxygenases (HOs). These reactions also generate biliverdin, bilirubin (BR), and iron. The conversion of biliverdin to BR is catalyzed by biliverdin reductase-A (BVR-A). In this review, we focus on the importance of the HO-1/CO system and BVR in the pathophysiology and therapy of inflammation associated with diabetes.
C1 [Rochette, Luc; Zeller, Marianne; Cottin, Yves; Vergely, Catherine] Univ Bourgogne Franche Comte, Res Team Pathophysiol & Epidemiol Cerebrocardiova, UFR Sci Sante, 7 Blvd Jeanne dArc, F-21079 Dijon, France.
   [Cottin, Yves] CHU Dijon, Cardiol Unit, F-21000 Dijon, France.
C3 Universite Bourgogne Europe; Universite Bourgogne Europe; CHU Dijon
   Bourgogne
RP Rochette, L (corresponding author), Univ Bourgogne Franche Comte, Res Team Pathophysiol & Epidemiol Cerebrocardiova, UFR Sci Sante, 7 Blvd Jeanne dArc, F-21079 Dijon, France.
EM luc.rochette@u-bourgogne.fr
RI COTTIN, YVES/ABA-4622-2020; VERGELY, CATHERINE/L-9534-2015
OI VERGELY, CATHERINE/0000-0003-4009-776X
FU French Ministry of Research; INSERM (Institut National de la Sante et de
   la Recherche Medicale); Regional Council of Burgundy (Conseil Regional
   de Bourgogne); FEDER; Association de Cardiologie de Bourgogne
FX This work was supported by grants from French Ministry of Research,
   INSERM (Institut National de la Sante et de la Recherche Medicale) and,
   from the Regional Council of Burgundy (Conseil Regional de Bourgogne),
   FEDER, and Association de Cardiologie de Bourgogne. The authors have no
   other relevant affiliations or financial involvement with any
   organization or entity with a financial interest in or financial
   conflict with the subject matter or materials discussed in the
   manuscript apart from those disclosed. The authors wish to thank Martine
   Goiset for secretarial assistance and Philip Bastable for English
   assistance.
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NR 75
TC 84
Z9 90
U1 0
U2 13
PU ELSEVIER SCIENCE LONDON
PI LONDON
PA 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND
SN 1043-2760
EI 1879-3061
J9 TRENDS ENDOCRIN MET
JI Trends Endocrinol. Metab.
PD FEB
PY 2018
VL 29
IS 2
BP 74
EP 85
DI 10.1016/j.tem.2017.11.005
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA FS9NS
UT WOS:000422745600003
PM 29249571
DA 2025-06-11
ER

PT J
AU Zhang, NH
   Kong, F
   Jing, XX
   Zhou, JX
   Zhao, L
   Soliman, MM
   Zhang, LB
   Zhou, F
AF Zhang, Nanhai
   Kong, Fang
   Jing, Xiaoxuan
   Zhou, Jingxuan
   Zhao, Liang
   Soliman, Mohamed Mohamed
   Zhang, Liebing
   Zhou, Feng
TI Hongqu Rice Wines Ameliorate High-Fat/High-Fructose Diet-Induced
   Metabolic Syndrome in Rats
SO ALCOHOL AND ALCOHOLISM
LA English
DT Article
ID OXIDATIVE STRESS; DIABETES-MELLITUS; RISK; ALCOHOL; OBESITY;
   DYSLIPIDEMIA; METAANALYSIS; SUPPRESSION; PREVENTION; LOWERS
AB Short Summary: Hongqu rice wines alleviated high-fat/high-fructose diet-induced metabolic syndrome in rats via ameliorating glucose and lipid metabolic disorders, attenuating hepatic and renal damage, reducing the release of inflammatory cytokines and enhancing antioxidant capacities.
   Aim This study evaluated the possible protective impact of different vintages of Hongqu rice wines on metabolic syndrome (MetS) in rats induced by high-fat/high-fructose diet (HFFD). Methods Rats were randomly divided into six groups and treated with (a) basal diet (13.9 kJ/g); (b) HFFD (20.0% w/w lard and 18.0% fructose, 18.9 kJ/g) and (c-f) HFFD with 3-, 5-, 8- and 15-year-aged Hongqu rice wines (9.96 ml/kg body weight), respectively, at an oral route for 20 weeks. Results Hongqu rice wines could alleviate HFFD-induced augment of body weight gain and fat accumulation, and the release of pro-inflammatory cytokines. Glycolipid metabolic abnormalities caused by HFFD were ameliorated after Hongqu rice wines consumption by lowering levels of fasting insulin, GSP, HOMA-IR, AUC of OGTT and ITT, and lipid deposition (reduced contents of TG, TC, FFA and LDL-C, and elevated HDL-C level) in the serum and liver, probably via regulating expressions of genes involving in IRS1/PI3K/AKT pathway, LDL-C uptake, fatty acid beta-oxidation, and lipolysis, export and synthesis of TG. In addition, concentrations of MDA and blood pressure markers (ANG-II and ET-1) declined, and activities of antioxidant enzymes (SOD and CAT) were improved in conditions of Hongqu rice wines compared to those in the HFFD group. Eight-year-aged Hongqu rice wine produced a more effective effect on alleviating HFFD-caused MetS among different vintages of Hongqu rice wines. Conclusion To sum up, Hongqu rice wines exhibited ameliorative effects on HFFD-induced MetS in rats based on antiobesity, antihyperlipidemic, antihyperglycemic, antioxidant, anti-inflammatory and potential antihypertensive properties.
C1 [Zhang, Nanhai; Kong, Fang; Jing, Xiaoxuan; Zhou, Jingxuan; Zhang, Liebing; Zhou, Feng] China Agr Univ, Coll Food Sci & Nutr Engn, Beijing Key Lab Funct Food Plant Resources, 17 Tsinghua East Rd, Beijing 100083, Peoples R China.
   [Zhao, Liang] Beijing Technol & Business Univ, Beijing Engn & Technol Res Ctr Food Addit, Beijing Adv Innovat Ctr Food Nutr & Human Hlth, Beijing 100048, Peoples R China.
   [Soliman, Mohamed Mohamed] Taif Univ, Turabah Univ Coll, Clin Lab Sci Dept, POB 11099, Taif 21944, Saudi Arabia.
C3 China Agricultural University; Beijing Technology & Business University;
   Taif University
RP Zhou, F (corresponding author), China Agr Univ, Coll Food Sci & Nutr Engn, Beijing Key Lab Funct Food Plant Resources, 17 Tsinghua East Rd, Beijing 100083, Peoples R China.
EM nanhaizhang@cau.edu.cn; kongfff@cau.edu.cn; JXX0521@cau.edu.cn;
   zjx888@cau.edu.cn; liangzhao@btbu.edu.cn; mmsoliman@tu.edu.sa;
   lbzhang@cau.edu.cn; zf@cau.edu.cn
RI Soliman, Mohamed/ABJ-0997-2022; jing, xiaoxuan/JFA-5074-2023
OI Soliman, Mohamed Mohamed/0000-0001-7208-7123
FU Taif University, Taif, Saudi Arabia [TURSP-2020/09]; Analysis of the
   Active Components and Function Evaluation of Danxi Hongqu Rice Wines
   [202205410610167]
FX This work was supported by Analysis of the Active Components and
   Function Evaluation of Danxi Hongqu Rice Wines (202205410610167) and the
   Taif University Researchers SupportingProject (TURSP-2020/09), Taif
   University, Taif, Saudi Arabia.
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NR 50
TC 1
Z9 1
U1 6
U2 46
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0735-0414
EI 1464-3502
J9 ALCOHOL ALCOHOLISM
JI Alcohol Alcohol.
PD NOV 11
PY 2022
VL 57
IS 6
BP 776
EP 787
DI 10.1093/alcalc/agac033
EA AUG 2022
PG 12
WC Substance Abuse
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Substance Abuse
GA 6C5OJ
UT WOS:000835559500001
PM 35922962
DA 2025-06-11
ER

PT J
AU Chang, JH
   Chen, IH
   Geng, JH
   Wu, PY
   Huang, JC
   Chen, SC
AF Chang, Jung-Hsiu
   Chen, I-Hua
   Geng, Jiun-Hung
   Wu, Pei-Yu
   Huang, Jiun-Chi
   Chen, Szu-Chia
TI Metabolic Syndrome Is Associated with Cataract in a Large Taiwanese
   Population Study
SO NUTRIENTS
LA English
DT Article
DE metabolic syndrome; cataract; Taiwan Biobank
ID C-REACTIVE PROTEIN; AGE-RELATED CATARACT; BODY-MASS INDEX; RISK-FACTORS;
   OXIDATIVE STRESS; LENS OPACITIES; CARDIOVASCULAR-DISEASE; INFLAMMATORY
   MARKERS; SYNDROME COMPONENTS; CENTRAL OBESITY
AB Cataract is the leading cause of blindness worldwide, and metabolic syndrome (MetS) is a known risk factor. In this study, we investigated the association between the risk of cataract with MetS and its components in a large-scale study. Data were derived from the Taiwan Biobank, and 121,380 individuals were included. The NCEP-ATP III criteria modified for use in an Asian population were used to define MetS and its components. The occurrence of cataract was identified through a standardized interview and self-reported questionnaire. Multivariable analysis showed that MetS (OR, 1.129; 95% CI, 1.0175-1.184; p < 0.001), low high-density lipoprotein (HDL)-cholesterol (OR, 1.057; 95% CI, 1.005-1.113; p = 0.032), and hyperglycemia (OR, 1.162; 95% CI, 1.108-1.218; p < 0.001) were significantly associated with cataract. Furthermore, a stepwise increase in the prevalence of cataract corresponding to the number of MetS components was found. The presence of three MetS components (vs. 0; OR, 1.103; 95% CI, 1.024-1.188; p = 0.010), four MetS components (vs. 0; OR, 1.137; 95% CI, 1.040-1.242; p = 0.005), and five MetS components (vs. 0; OR, 1.208; 95% CI, 1.059-1.378; p = 0.005) were significantly associated with cataract. In conclusion, significant associations were found between a high incidence of cataract with MetS and its components, including low HDL-cholesterolemia and hyperglycemia. Further, a stepwise increase in the prevalence of cataract corresponding to the number of MetS components was also found. The results of this study indicate that MetS may increase the development of cataract in Taiwan.
C1 [Chang, Jung-Hsiu] Kaohsiung Med Univ, Dept Post Baccalaureate Med, Kaohsiung 807, Taiwan.
   [Chen, I-Hua] Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Internal Med, Div Endocrinol & Metab, Kaohsiung 807, Taiwan.
   [Geng, Jiun-Hung] Kaohsiung Med Univ, Kaohsiung Municipal Siaogang Hosp, Dept Urol, Kaohsiung 812, Taiwan.
   [Geng, Jiun-Hung] Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Urol, Kaohsiung 807, Taiwan.
   [Wu, Pei-Yu; Huang, Jiun-Chi; Chen, Szu-Chia] Kaohsiung Med Univ, Kaohsiung Municipal Siaogang Hosp, Dept Internal Med, Kaohsiung 812, Taiwan.
   [Wu, Pei-Yu; Huang, Jiun-Chi; Chen, Szu-Chia] Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Internal Med, Div Nephrol, Kaohsiung 807, Taiwan.
   [Huang, Jiun-Chi; Chen, Szu-Chia] Kaohsiung Med Univ, Coll Med, Fac Med, Kaohsiung 807, Taiwan.
   [Chen, Szu-Chia] Kaohsiung Med Univ, Res Ctr Environm Med, Kaohsiung 807, Taiwan.
C3 Kaohsiung Medical University; Kaohsiung Medical University; Kaohsiung
   Medical University Hospital; Kaohsiung Medical University; Kaohsiung
   Municipal Siao-Gang Hospital; Kaohsiung Medical University; Kaohsiung
   Medical University Hospital; Kaohsiung Medical University; Kaohsiung
   Municipal Siao-Gang Hospital; Kaohsiung Medical University; Kaohsiung
   Medical University Hospital; Kaohsiung Medical University; Kaohsiung
   Medical University
RP Chen, SC (corresponding author), Kaohsiung Med Univ, Kaohsiung Municipal Siaogang Hosp, Dept Internal Med, Kaohsiung 812, Taiwan.; Chen, SC (corresponding author), Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Internal Med, Div Nephrol, Kaohsiung 807, Taiwan.; Chen, SC (corresponding author), Kaohsiung Med Univ, Coll Med, Fac Med, Kaohsiung 807, Taiwan.; Chen, SC (corresponding author), Kaohsiung Med Univ, Res Ctr Environm Med, Kaohsiung 807, Taiwan.
EM jasonjrchang@gmail.com; control521@gmail.com; u9001090@gmail.com;
   wpuw17@gmail.com; karajan77@gmail.com; scarchenone@yahoo.com.tw
RI Huang, Jiun-Chi/IAQ-1908-2023; GENG, JIUNHUNG/AAB-2322-2022; 蘇,
   河名/AAE-9843-2019
OI Huang, Jiun-Chi/0000-0002-5897-2860; GENG, JIUNHUNG/0000-0003-0610-1278;
   Chang, Jung Hsiu/0000-0001-6121-799X; Chen, Szu-Chia/0000-0002-1610-4184
FU Research Center for Environmental Medicine, Kaohsiung Medical
   University, Kaohsiung, Taiwan, from The Featured Areas Research Center
   Program; Kaohsiung Medical University Research Center Grant
   [KMU-TC110A01Ans, KMUTC111IFSP01]
FX This work was supported partially by the Research Center for
   Environmental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan,
   from The Featured Areas Research Center Program within the framework of
   the Higher Education Sprout Project by the Ministry of Education (MOE)
   in Taiwan and by Kaohsiung Medical University Research Center Grant
   (KMU-TC110A01Ans and KMUTC111IFSP01).
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NR 68
TC 4
Z9 4
U1 0
U2 2
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD MAY
PY 2022
VL 14
IS 9
AR 1684
DI 10.3390/nu14091684
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 1E8BU
UT WOS:000794707700001
PM 35565652
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Kagota, S
   Maruyama-Fumoto, K
   McGuire, JJ
   Shinozuka, K
AF Kagota, Satomi
   Maruyama-Fumoto, Kana
   McGuire, John J.
   Shinozuka, Kazumasa
TI A Sodium Glucose Cotransporter 2 Inhibitor Fails to Improve Perivascular
   Adipose Tissue-Mediated Modulation of Vasodilation and Cardiac Function
   in Rats With Metabolic Syndrome
SO JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS
LA English
DT Article
DE adipose tissue; metabolic syndrome; sodium glucose cotransporter-2
   inhibitors; tofogliflozin; vasodilation
ID SELECTIVE SGLT2 INHIBITOR; BLOOD-PRESSURE; SHRSP.Z-LEPR(FA)/IZMDMCR
   RATS; ENDOTHELIAL DYSFUNCTION; GLYCEMIC CONTROL; HEART-FAILURE;
   ANIMAL-MODEL; EMPAGLIFLOZIN; TOFOGLIFLOZIN; STRESS
AB Arterial perivascular adipose tissue (PVAT) can elicit vasodilator signals complementary to those elicited by the endothelium in SHRSP.Z-Lepr(fa) /IzmDmcr (SHRSP.ZF) rats, an animal model of metabolic syndrome (MetS). Here, we tested whether a glucose cotransporter 2 inhibitor (SGLT2-i; tofogliflozin) increased this PVAT effect to prevent the deterioration of cardiac function in aging SHRSP.ZF rats. Tofogliflozin treatments (1 or 10 mg/kg/day) or vehicle (control) were administered for 10 weeks by oral gavage to SHRSP.ZF rats, starting at 13 weeks of age. At 23 weeks of age, glucose levels in the serum and urine (24 h after the last administration) were determined using commercial kits. Vasodilator responsiveness of PVAT-surrounded or PVAT-free superior mesenteric arteries was determined using acetylcholine with organ-bath methods. Cardiac ventricular function and coronary flow were determined using Langendorff heart preparations. Serum and urine glucose levels in SGLT2-i treatment groups did not differ from those in the controls, but the ratios of glycated to non-glycated albumin were lower than those in the controls. Tofogliflozin treatments did not alter relaxations in the presence of PVAT or affect relaxations of PVAT-free arteries. Left ventricular systolic pressures, maximum rate of pressure decline, and coronary flow in ex vivo hearts did not differ among the treatment groups. PVAT effects and cardiac dysfunction were not altered by tofogliflozin treatment in SHRSP.ZF rats with MetS. These results do not provide strong evidence to support the use of SGLT2-i as a cardiovascular protective therapy in MetS, which occurs prior to the onset of type 2 diabetes.
C1 [Kagota, Satomi; Maruyama-Fumoto, Kana; Shinozuka, Kazumasa] Mukogawa Womens Univ, Sch Pharm & Pharmaceut Sci, Dept Pharmacol, Nishinomiya, Hyogo, Japan.
   [Kagota, Satomi] Mukogawa Womens Univ, Inst Biosci, Nishinomiya, Hyogo, Japan.
   [McGuire, John J.] Western Univ, Dept Med Biophys, Schulich Sch Med & Dent, London, ON, Canada.
C3 Mukogawa Women's University; Mukogawa Women's University; Western
   University (University of Western Ontario)
RP Kagota, S (corresponding author), Mukogawa Womens Univ, Sch Pharm & Pharmaceut Sci, 11-68 Koshien Kyuban Cho, Nishinomiya, Hyogo 6638179, Japan.
EM skagota@mukogawa-u.ac.jp
OI McGuire, John/0000-0003-0302-3884; Kagota, Satomi/0000-0003-2044-5552
CR Connelly KA, 2020, CARDIOVASC DIABETOL, V19, DOI 10.1186/s12933-020-0994-y
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NR 40
TC 3
Z9 3
U1 0
U2 3
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1074-2484
EI 1940-4034
J9 J CARDIOVASC PHARM T
JI J. Cardiovasc. Pharmacol. Ther.
PD SEP
PY 2021
VL 26
IS 5
BP 480
EP 489
AR 10742484211001853
DI 10.1177/10742484211001853
EA MAR 2021
PG 10
WC Cardiac & Cardiovascular Systems; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Pharmacology & Pharmacy
GA TE9LJ
UT WOS:000634495200001
PM 33764804
DA 2025-06-11
ER

PT J
AU Appiah, CA
   Afriyie, EO
   Hayford, FEA
   Frimpong, E
AF Appiah, Collins Afriyie
   Afriyie, Edward Opoku
   Hayford, Frank Ekow Atta
   Frimpong, Emmanuel
TI Prevalence and lifestyle-associated risk factors of metabolic syndrome
   among commercial motor vehicle drivers in a metropolitan city in Ghana
SO PAN AFRICAN MEDICAL JOURNAL
LA English
DT Article
DE Metabolic syndrome; overweight/obesity; diabetes; hypertension;
   dyslipidemia; lifestyle-related behaviors; commercial motor vehicle
   drivers
ID CORONARY-HEART-DISEASE; DEFINITION; STRESS
AB Introduction: commercial motor vehicle drivers are at risk of metabolic syndrome (MetS) due to the nature of their work as they tend to go to work early, work for more hours, have irregular dietary habits and patterns, have little sleep and live sedentary lifestyle. The study sought to determine the prevalence and lifestyle-related risk factors of MetS among commercial taxi drivers around Kwame Nkrumah University of Science and Technology (KNUST) campus, in the Kumasi metropolis, Ghana.
   Methods: a cross-sectional survey was conducted among 100 commercial taxi drivers in 3 selected taxi ranks around KNUST campus. Fasting blood lipid and fasting blood glucose levels, blood pressure and anthropometric characteristics were determined using WHO and NCEP-ATP III criteria. Lifestyle-related risk factors of MetS were assessed using a semi-structured questionnaire and dietary pattern was assessed using food frequency questionnaire. Bivariate analysis and linear correlation were used to determine the relationship between lifestyle practices and MetS.
   Results: the prevalence of diabetes, high blood pressure, dyslipidemia, overweight and obesity were 12%, 63%, 40%, 32% and 13% respectively. The prevalence of MetS was 5% according to NCEP-ATP III (2005) criteria. The lifestyle behaviours of the drivers were, alcohol intake, irregular dietary pattern, long working hours, lack of exercise and tiredness due to driving. Tobacco use (R = 0.405, p = 0.041) and time of supper (R = 0.931, p = 0.047) were related with MetS among the participants.
   Conclusion: though prevalence of MetS (5%) was low among the drivers, the need for intervention to promote positive lifestyle change and curb the high prevalence of overweight/obesity, diabetes, high blood pressure and dyslipidemia is necessary to improve the health of the drivers and the safety of passengers.
C1 [Appiah, Collins Afriyie; Afriyie, Edward Opoku; Frimpong, Emmanuel] Kwame Nkrumah Univ Sci & Technol, Coll Sci, Fac Biosci, Dept Biochem & Biotechnol,Human Nutr & Dietet Uni, Kumasi, Ghana.
   [Hayford, Frank Ekow Atta] Univ Ghana, Coll Hlth Sci, Sch Biomed & Allied Hlth Sci, Dept Nutr & Dietet, Accra, Ghana.
   [Hayford, Frank Ekow Atta] North West Univ, Fac Hlth Sci, Ctr Excellence Nutr, Potchefstroom Campus, Potchefstroom, South Africa.
C3 Kwame Nkrumah University Science & Technology; University of Ghana;
   North West University - South Africa
RP Appiah, CA (corresponding author), Kwame Nkrumah Univ Sci & Technol, Coll Sci, Fac Biosci, Dept Biochem & Biotechnol,Human Nutr & Dietet Uni, Kumasi, Ghana.
EM caappiah.cos@knust.edu.gh
RI Hayford, Frank/AGR-3353-2022
OI Hayford, Dr Frank Ekow Atta/0000-0001-5950-2935; Appiah, Collins
   Afriyie/0000-0003-0002-9164
CR Abban HA, 2013, THESIS, V2013, P70
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NR 29
TC 12
Z9 12
U1 1
U2 7
PU AFRICAN FIELD EPIDEMIOLOGY NETWORK-AFENET
PI KAMPALA
PA PO BOX 12874, KAMPALA, 00000, UGANDA
SN 1937-8688
J9 PAN AFR MED J
JI Pan Afr. Med. J.
PD JUN 29
PY 2020
VL 36
AR 136
DI 10.11604/pamj.2020.36.136.16861
PG 16
WC Public, Environmental & Occupational Health
WE Emerging Sources Citation Index (ESCI)
SC Public, Environmental & Occupational Health
GA MY7SQ
UT WOS:000558616400001
PM 32849991
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Fu, SH
   Yao, Y
   Zhao, YL
   Luan, FX
AF Fu, Shihui
   Yao, Yao
   Zhao, Yali
   Luan, Fuxin
TI Relationships of Hyperhomocysteinemia and Hyperuricemia With Metabolic
   Syndrome and Renal Function in Chinese Centenarians
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Article
DE Chinese centenarians; hyperhomocysteinemia; hyperuricemia; metabolic
   syndrome; renal function
ID CHRONIC KIDNEY-DISEASE; URIC-ACID LEVELS; CARDIOVASCULAR-DISEASE; PLASMA
   HOMOCYSTEINE; INSULIN-RESISTANCE; OXIDATIVE STRESS; UNITED-STATES;
   RISK-FACTORS; PREVALENCE; POPULATION
AB As the first time worldwide, this study aimed to investigate the relationships of hyperhomocysteinemia and hyperuricemia with metabolic syndrome (MetS) and renal function in Chinese centenarians. The China Hainan Centenarian Cohort Study was performed in 18 cities and counties of the Hainan Province. Home interview, physical examination, and blood analysis were performed on 808 centenarians following standard procedures. All centenarians had a median age of 102 (100-115) years. Prevalence of hyperhomocysteinemia and hyperuricemia was 91.6% (740 centenarians) and 28.5% (230 centenarians), respectively. The MetS was present in 117 centenarians (14.5%). In simple correlation analyses, hyperhomocysteinemia and hyperuricemia were significantly correlated with MetS and glomerular filtration rate (GFR) < 60 ml/min/1.73 m(2) (P < 0.05 for all). Serum homocysteine levels were significantly correlated with GFR, waist circumference (WC), and triglyceride levels, while serum uric acid levels were significantly correlated with these variables plus high-density lipoprotein cholesterol (HDL-C) levels (P < 0.05 for all). In logistic regression analyses, hyperhomocysteinemia and hyperuricemia were significantly associated with MetS and GFR < 60 ml/min/1.73 m2 (P < 0.05 for all). In linear regression analyses, serum homocysteine levels were significantly associated with GFR, WC, and triglyceride, while serum uric acid levels were significantly associated with these variables plus HDL-C (P < 0.05 for all). Both hyperhomocysteinemia and hyperuricemia had important relationships with MetS and renal function in Chinese centenarians. Hyperuricemia and hyperhomocysteinemia that could help identify, while also affecting, the development of MetS and renal function may unfold complex relationships between MetS, renal function, and cardiovascular risk and provide effective prevention strategies for these conditions.
C1 [Fu, Shihui] Chinese Peoples Liberat Army Gen Hosp, Dept Geriatr Cardiol, Beijing, Peoples R China.
   [Fu, Shihui] Chinese Peoples Liberat Army Gen Hosp, Dept Cardiol, Beijing, Peoples R China.
   [Fu, Shihui] Chinese Peoples Liberat Army Gen Hosp, Hainan Branch, Beijing, Peoples R China.
   [Yao, Yao] Chinese Peoples Liberat Army Gen Hosp, Inst Geriatr, Beijing, Peoples R China.
   [Yao, Yao] Chinese Peoples Liberat Army Gen Hosp, Beijing Key Lab Geriatr, Beijing, Peoples R China.
   [Zhao, Yali; Luan, Fuxin] Chinese Peoples Liberat Army Gen Hosp, Hainan Branch, Cent Lab, Sanya, Peoples R China.
C3 Chinese People's Liberation Army General Hospital; Chinese People's
   Liberation Army General Hospital; Chinese People's Liberation Army
   General Hospital; Chinese People's Liberation Army General Hospital;
   Chinese People's Liberation Army General Hospital; Chinese People's
   Liberation Army General Hospital
RP Zhao, YL; Luan, FX (corresponding author), Chinese Peoples Liberat Army Gen Hosp, Hainan Branch, Cent Lab, Sanya, Peoples R China.
EM zhaoyl301@163.com; baisui301@163.com
RI Yao, Yao/MIQ-7775-2025; Yao, Yao/AAH-2712-2021
OI Yao, Yao/0000-0002-6723-6152; Fu, Shihui/0000-0001-6707-9049
FU Key Research and Development Program of Hainan [ZDYF2016135,
   ZDYF2017095]; Sanya Medical and Health Science and Technology Innovation
   Project [2016YW21]; Clinical Scientific Research Supporting Fund of
   Chinese People's Liberation Army General Hospital [2017FC-CXYY-3009]
FX This work was supported by grants from the Key Research and Development
   Program of Hainan (ZDYF2016135 and ZDYF2017095), Sanya Medical and
   Health Science and Technology Innovation Project (2016YW21), and
   Clinical Scientific Research Supporting Fund of Chinese People's
   Liberation Army General Hospital (2017FC-CXYY-3009). The sponsors had no
   role in the design, conduct, interpretation, review, approval, or
   control of this article.
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NR 48
TC 17
Z9 18
U1 0
U2 6
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD SEP 11
PY 2018
VL 9
AR 502
DI 10.3389/fendo.2018.00502
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA GT1XD
UT WOS:000444269600001
PM 30271378
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Hazarika, A
   Kalita, H
   Boruah, DC
   Kalita, MC
   Devi, R
AF Hazarika, Ankita
   Kalita, Himadri
   Boruah, Dulal Chandra
   Kalita, Mohan Chandra
   Devi, Rajlakshmi
TI Pathophysiology of metabolic syndrome: The onset of natural recovery on
   withdrawal of a high-carbohydrate, high-fat diet
SO NUTRITION
LA English
DT Article
DE Dyslipidemia; Fructose; High-carbohydrate; High-fat diet;
   Histopathology; Metabolic syndrome; Reactive oxygen species
ID OXIDATIVE STRESS; FRUCTOSE; DISEASE; INFLAMMATION; CONSUMPTION;
   ADIPOCYTES; INCREASE; SUCROSE; KIDNEY
AB Objectives: Chronic consumption of high-carbohydrate, high-fat (HCHF) diet induces metabolic syndrome (MetS) and markedly impairs the ultra-structure of organs. To our knowledge, no scientific study has yet to report the effect of withdrawal of an HCHF diet on MetS-associated ultra structural abnormalities in affected organs and tissues. Therefore, the aim of this study was to investigate the effects of subchronic withdrawal of the HCHF diet, specifically with a pathophysiological approach.
   Methods: Wister albino rats (N = 72) were divided into three groups: Groups A and B were fed a standard basal diet and an HCHF diet, respectively, for 16 wk. Group C was on an HCHF diet for the initial 12 wk and then returned to basal diet for 4 wk. Histopathological changes in the heart, lungs, liver, spleen, pancreas, small intestine, kidney, white adipose tissue (WAT), skeletal muscle, and hippocampus of the brain were monitored at 4, 8, 12, and 16 wk.
   Results: Lipid droplets (LDs) in liver, fibrosis in the pancreas, abnormalities in the glomerulus of the kidney, and an increase in the size of adipocytes were observed in groups B and C at week 12. Withdrawal of the HCHF diet in group C showed the onset of regenerative features at the ultra structural level. HCHF diet-fed rats in group B had higher body weights; raised lipid profiles, blood glucose levels, and insulin resistance than basal diet-fed rats in group A and HCHF to basal diet-fed rats in group C at week 16.
   Conclusion: An HCHF diet induces ultra-structural abnormalities, which are significantly reversed by subchronic withdrawal of a MetS-inducing HCHF diet, indicating the onset of natural recovery at the ultra-structural level of affected organs. (C) 2016 Elsevier Inc. All rights reserved.
C1 [Hazarika, Ankita; Kalita, Himadri; Devi, Rajlakshmi] Inst Adv Study Sci & Technol, Div Life Sci, Gauhati, Assam, India.
   [Boruah, Dulal Chandra] Goalpara Coll, Dept Bot, Goalpara, Assam, India.
   [Kalita, Mohan Chandra] Gauhati Univ, Dept Biotechnol, Gauhati, Assam, India.
C3 Department of Science & Technology (India); Institute of Advanced Study
   in Science & Technology (IASST); Gauhati University
RP Devi, R (corresponding author), Inst Adv Study Sci & Technol, Div Life Sci, Gauhati, Assam, India.
EM biochemistry.iasst@gmail.com
RI Baruah, Dr Dulal/GON-6608-2022
OI BORUAH, DULAL CHANDRA/0000-0001-7423-1555
FU Department of Science and Technology, government of India, New Delhi
FX The authors acknowledge the Department of Science and Technology,
   government of India, New Delhi for financial support. They acknowledge
   the Institute of Advanced Studies in Science and Technology, Guwahati,
   Assam for providing necessary facilities, as well as Kaushik Das and
   Aziz Khan for technical help with microscopy.
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NR 41
TC 17
Z9 18
U1 0
U2 20
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0899-9007
EI 1873-1244
J9 NUTRITION
JI Nutrition
PD OCT
PY 2016
VL 32
IS 10
BP 1081
EP 1091
DI 10.1016/j.nut.2016.03.005
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA DU7YE
UT WOS:000382429700007
PM 27209212
DA 2025-06-11
ER

PT J
AU Lin, YC
   Hsiao, TJ
   Chen, PC
AF Lin, Yu-Cheng
   Hsiao, Tun-Jen
   Chen, Pau-Chung
TI Shift work aggravates metabolic syndrome development among
   early-middle-aged males with elevated ALT
SO WORLD JOURNAL OF GASTROENTEROLOGY
LA English
DT Article
DE Alanine aminotransferase; Early middle aged; Male; Metabolic syndrome;
   Shift work
ID FATTY LIVER-DISEASE; SERUM ALANINE AMINOTRANSFERASE; C-REACTIVE PROTEIN;
   5-YEAR FOLLOW-UP; INSULIN-RESISTANCE; CARDIOVASCULAR-DISEASE;
   RISK-FACTORS; OXIDATIVE STRESS; CHOLESTEROL; HEALTHY
AB AIM: To examine whether shift work accelerates metabolic syndrome (MetS) development among early middle-aged males with elevated alanine aminotransferase (e-ALT).
   METHODS: A retrospective, observational follow-up study on MetS development at a 5-year interval was conducted using health examination data. Nine hundred and ninety six male employees not fulfilling MetS criteria at screening were enrolled. Age, MetS-components, liver enzymes, serological markers for viral hepatitis, abdominal ultrasound, insulin resistance status, lifestyles, and workplace factors were analyzed.
   RESULTS: The prevalence of elevated serum ALT (> 40 U/L, e-ALT) at baseline was 19.1%. There were 381 (38.3%) workers with long-term exposures to day-night rotating shift work (RSW). 14.2% of subjects developed MetS during follow-up. After 5 years, the workers with e-ALT had significantly unfavorable changes in MetS-components, and higher rates of MetS development, vs subjects with normal baseline ALT levels. Workers with both baseline e-ALT and 5-year persistent RSW (pRSW) exposure had the highest rate of MetS development. Also, e-ALT-plus-pRSW workers had a significant increase in MetS-components at follow-up, compared with the other subgroups. After controlling for potential confounders, e-ALT-plus-pRSW workers posed a significant risk for MetS development (odds ratio, 2.7; 95% confidence interval, 1.4-5.3, vs workers without baseline e-ALT nor pRSW).
   CONCLUSION: We suggest that all early middle-aged male employees with e-ALT should be evaluated and managed for MetS. Particularly in terms of job arrangements, impacts of long-term RSW on MetS development should be assessed for all male employees having baseline e-ALT. (C) 2009 The WJG Press and Baishideng. All rights reserved.
C1 [Lin, Yu-Cheng; Chen, Pau-Chung] Natl Taiwan Univ, Coll Publ Hlth, Inst Occupat Med & Ind Hyg, Taipei 100, Taiwan.
   [Lin, Yu-Cheng] Tao Yuan Gen Hosp, Dept Occupat Med, Tao Yuan 330, Taiwan.
   [Hsiao, Tun-Jen] Taipei Med Univ, Coll Publ Hlth & Nutr, Taipei 110, Taiwan.
C3 National Taiwan University; Taipei Medical University
RP Chen, PC (corresponding author), Natl Taiwan Univ, Coll Publ Hlth, Inst Occupat Med & Ind Hyg, 17 Xu Zhou Rd, Taipei 100, Taiwan.
EM pchen@ntu.edu.tw
RI 林, 煜程/HSI-3146-2023; Chen, Pau-Chung/H-5686-2011
OI Chu, Yuen-Kuei/0009-0002-5873-5619; Lin, Yu Cheng/0000-0003-4648-8745;
   Chen, Pau-Chung/0000-0002-6242-5974
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NR 39
TC 29
Z9 35
U1 0
U2 6
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 8226 REGENCY DR, PLEASANTON, CA 94588 USA
SN 1007-9327
EI 2219-2840
J9 WORLD J GASTROENTERO
JI World J. Gastroenterol.
PD DEC 7
PY 2009
VL 15
IS 45
BP 5654
EP 5661
DI 10.3748/wjg.15.5654
PG 8
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 529UP
UT WOS:000272544600004
PM 19960561
OA hybrid, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Wuriliga
   Xu, D
   He, Y
   Xu, D
   Chen, BD
   Li, X
   Zhang, XY
   Zhang, J
   Shen, M
   Mu, R
AF Wuriliga
   Xu, Dong
   He, Yang
   Xu, Dan
   Chen, Beidi
   Li, Xue
   Zhang, Xiaoying
   Zhang, Jun
   Shen, Ming
   Mu, Rong
TI Mild cognitive impairment in patients with systemic sclerosis and
   features analysis
SO RHEUMATOLOGY
LA English
DT Article
DE SSc; mild cognitive impairment; Montreal cognitive assessment
ID METABOLIC SYNDROME; SCLERODERMA; DEPRESSION; DEMENTIA; ANXIETY
AB Objective Nervous system damage in patients with SSc has recently attracted attention. In this study, we aimed to explore mild cognitive impairment (MCI) in SSc patients and the characteristics of these patients. Methods A total of 103 SSc patients were consecutively enrolled from July 2018 to May 2019, and 97 matched healthy individuals were also included as controls. Brief cognitive tests, such as the Beijing version of the Montreal Cognitive Assessment (MoCA-BJ), were used to assess the cognitive function of all subjects. We compared the differences in MCI between SSc patients and healthy controls, as well as the differences in demographic and clinical features between SSc patients with and without MCI. Associations of quantitative demographic and clinical features with MoCA-BJ scores in the SSc patients were also evaluated. Results The score of MoCA-BJ was lower in the SSc group compared with those in the healthy group [24 (9-30) vs 26 (15-30), P< 0.001]. MCI (MoCA-BJ score <= 25) was found in 61.2% (63/103) of the enrolled SSc patients but only in 27.8% (27/97) of the healthy individuals. Other tests evaluating some of the specific domains of cognitive functions showed that the SSc patients had impaired memory, attention and executive ability. Compared with SSc patients without MCI, SSc patients with MCI had lower education level, total serum protein and serum albumin but higher ANA positivity. Conclusion MCI is common in patients with SSc and should be drawn to the attention of rheumatologists. Lower education level, malnutrition and higher ANA positivity were closely related to the cognitive dysfunctions in SSc patients, providing directions for further interventions.
C1 [Wuriliga; Xu, Dan; Chen, Beidi; Mu, Rong] Peking Univ Third Hosp, Dept Rheumatol & Immunol, 49 North Hua Yuan Ave, Beijing 100191, Peoples R China.
   [Wuriliga] Affiliated Hosp Inner Mongolia Med Univ, Dept Rheumatol & Immunol, Hohhot, Inner Mongolia, Peoples R China.
   [Xu, Dong] Peking Union Med Coll Hosp, Dept Rheumatol & Immunol, Beijing, Peoples R China.
   [He, Yang; Zhang, Jun; Shen, Ming] Peking Univ Peoples Hosp, Dept Neurol, Beijing, Peoples R China.
   [Li, Xue; Zhang, Xiaoying; Mu, Rong] Peking Univ Peoples Hosp, Dept Rheumatol & Immunol, Beijing, Peoples R China.
C3 Chinese Academy of Medical Sciences - Peking Union Medical College;
   Peking Union Medical College Hospital; Peking University; Peking
   University
RP Mu, R (corresponding author), Peking Univ Third Hosp, Dept Rheumatol & Immunol, 49 North Hua Yuan Ave, Beijing 100191, Peoples R China.
EM murongster@163.com
RI 陈, 蓓迪/ADV-1872-2022
OI Chen, Beidi/0000-0002-7586-1855; , Wuriliga/0000-0001-7801-4240
FU National Natural Science Foundation of China [81771706]
FX This work was supported by the National Natural Science Foundation of
   China (grants 81771706).
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NR 28
TC 5
Z9 5
U1 0
U2 3
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1462-0324
EI 1462-0332
J9 RHEUMATOLOGY
JI RHEUMATOLOGY
PD MAY 30
PY 2022
VL 61
IS 6
BP 2457
EP 2463
DI 10.1093/rheumatology/keab787
EA NOV 2021
PG 7
WC Rheumatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Rheumatology
GA 1T0FI
UT WOS:000789242700001
PM 39806733
DA 2025-06-11
ER

PT J
AU Venturini, E
   Iannuzzo, G
   D'Andrea, A
   Pacileo, M
   Tarantini, L
   Canale, ML
   Gentile, M
   Vitale, G
   Sarullo, FM
   Vastarella, R
   Di Lorenzo, A
   Testa, C
   Parlato, A
   Vigorito, C
   Giallauria, F
AF Venturini, E.
   Iannuzzo, G.
   D'Andrea, A.
   Pacileo, M.
   Tarantini, L.
   Canale, M. L.
   Gentile, M.
   Vitale, G.
   Sarullo, F. M.
   Vastarella, R.
   Di Lorenzo, A.
   Testa, C.
   Parlato, A.
   Vigorito, C.
   Giallauria, F.
TI Oncology and Cardiac Rehabilitation: An Underrated Relationship
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Review
DE cancer; cardiovascular disease bidirectional relationship; exercise
   therapy in cancer; protection from cancer therapy; cardiac
   rehabilitation; cardio-oncology rehabilitation
ID RANDOMIZED CONTROLLED-TRIAL; CHRONIC HEART-FAILURE; ACUTE
   MYOCARDIAL-INFARCTION; DIETARY INFLAMMATORY INDEX; BREAST-CANCER
   SURVIVORS; LONG-TERM SURVIVORS; QUALITY-OF-LIFE; AEROBIC EXERCISE;
   PHYSICAL-ACTIVITY; METABOLIC SYNDROME
AB Cancer and cardiovascular diseases are globally the leading causes of mortality and morbidity. These conditions are closely related, beyond that of sharing many risk factors. The term bidirectional relationship indicates that cardiovascular diseases increase the likelihood of getting cancer and vice versa. The biological and biochemical pathways underlying this close relationship will be analyzed. In this new overlapping scenario, physical activity and exercise are proven protective behaviors against both cardiovascular diseases and cancer. Many observational studies link an increase in physical activity to a reduction in either the development or progression of cancer, as well as to a reduction in risk in cardiovascular diseases, a non-negligible cause of death for long-term cancer survivors. Exercise is an effective tool for improving cardio-respiratory fitness, quality of life, psychological wellbeing, reducing fatigue, anxiety and depression. Finally, it can counteract the toxic effects of cancer therapy. The protection obtained from physical activity and exercise will be discussed in the various stages of the cancer continuum, from diagnosis, to adjuvant therapy, and from the metastatic phase to long-term effects. Particular attention will be paid to the shelter against chemotherapy, radiotherapy, cardiovascular risk factors or new onset cardiovascular diseases. Cardio-Oncology Rehabilitation is an exercise-based multi-component intervention, starting from the model of Cardiac Rehabilitation, with few modifications, to improve care and the prognosis of a patient's cancer. The network of professionals dedicated to Cardiac Rehabilitation is a ready-to-use resource, for implementing Cardio-Oncology Rehabilitation.
C1 [Venturini, E.] Cecina Civil Hosp, Azienda USL Toscana Nord Ovest, Cardiac Rehabil Unit, I-57023 Li Cecina, Italy.
   [Iannuzzo, G.; Gentile, M.] Univ Naples Federico II, Dept Clin Med & Surg, I-80131 Naples, Italy.
   [D'Andrea, A.; Pacileo, M.] Umberto I Hosp, Unit Cardiol & Intens Care, Viale San Francesco, I-84014 Nocera Inferiore, SA, Italy.
   [Tarantini, L.] Osped San Martino ULSS1 Dolomiti, Div Cardiol, I-32100 Belluno, Italy.
   [Canale, M. L.] Osped Versilia, Azienda USL Toscana Nord Ovest, Dept Cardiol, I-55041 Lido Di Camaiore, LU, Italy.
   [Vitale, G.; Sarullo, F. M.] Buccheri La Ferla Fatebenefratelli Hosp, Cardiovasc Rehabil Unit, I-90123 Palermo, Italy.
   [Vastarella, R.] AORN Osped Colli Monaldi, UOSD Scompenso Cardiaco & Cardiol Riabilitat, I-80131 Naples, Italy.
   [Di Lorenzo, A.; Testa, C.; Parlato, A.; Vigorito, C.; Giallauria, F.] Federico II Univ Naples, Dept Translat Med Sci, I-80131 Naples, Italy.
C3 University of Naples Federico II; Ospedale Versilia; University of
   Naples Federico II
RP Venturini, E (corresponding author), Cecina Civil Hosp, Azienda USL Toscana Nord Ovest, Cardiac Rehabil Unit, I-57023 Li Cecina, Italy.
EM vent.elio@tin.it; gabriella.iannuzzo@unina.it;
   antonellodandrea@libero.it; pacmario@yahoo.it;
   luigi.tarantini@gmail.com; marialaura.canale@uslnordovest.toscana.it;
   margenti@unina.it; giuseppevit@hotmail.com; fsarullo@neomedia.it;
   rossellavastarella86@gmail.com; dilorenzoanna2@gmail.com;
   kre.testa@gmail.com; alessandroparlato96@gmail.com; vigorito@unina.it;
   francesco.giallauria@unina.it
RI Tarantini, Luigi/AAY-9493-2021; Sarullo, Filippo/AAJ-5853-2020;
   Venturini, Elio/ABC-8357-2020; iannuzzo, Gabriella/ABH-3527-2020;
   GENTILE, Marco/AAF-3013-2020
OI /0000-0002-8360-5173; Pacileo, Mario/0000-0002-6330-1738; Parlato,
   Alessandro/0009-0000-2108-511X; GENTILE, Marco/0000-0003-3744-6375;
   Vitale, Giuseppe/0000-0002-1565-6550; Venturini,
   Elio/0000-0001-7223-7574; Sarullo, Filippo/0000-0003-2046-8316;
   tarantini, luigi/0000-0003-2580-0963
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NR 162
TC 31
Z9 31
U1 2
U2 15
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD JUN
PY 2020
VL 9
IS 6
AR 1810
DI 10.3390/jcm9061810
PG 26
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA ML2SX
UT WOS:000549323300001
PM 32532011
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Li, ML
   Reynolds, CM
   Segovia, SA
   Gray, C
   Vickers, MH
AF Li, Minglan
   Reynolds, Clare M.
   Segovia, Stephanie A.
   Gray, Clint
   Vickers, Mark H.
TI Developmental Programming of Nonalcoholic Fatty Liver Disease: The
   Effect of Early Life Nutrition on Susceptibility and Disease Severity in
   Later Life
SO BIOMED RESEARCH INTERNATIONAL
LA English
DT Review
ID ENDOPLASMIC-RETICULUM STRESS; MATERNAL OBESITY; INSULIN-RESISTANCE;
   OXIDATIVE STRESS; NATURAL-HISTORY; METABOLIC-SYNDROME; HEPATIC
   STEATOSIS; MITOCHONDRIAL DYSFUNCTION; PRENATAL EXPOSURE; GENE-EXPRESSION
AB Nonalcoholic fatty liver disease (NAFLD) is fast becoming the most common liver disease globally and parallels rising obesity rates. The developmental origins of health and disease hypothesis have linked alterations in the early life environment to an increased risk of metabolic disorders in later life. Altered early life nutrition, in addition to increasing risk for the development of obesity, type 2 diabetes, and cardiovascular disease in offspring, is now associated with an increased risk for the development of NAFLD. This review summarizes emerging research on the developmental programming of NAFLD by both maternal obesity and undernutrition with a particular focus on the possible mechanisms underlying the development of hepatic dysfunction and potential strategies for intervention.
C1 [Vickers, Mark H.] Univ Auckland, Liggins Inst, Auckland 1142, New Zealand.
   Univ Auckland, Gravida Natl Ctr Growth & Dev, Auckland 1142, New Zealand.
C3 University of Auckland; University of Auckland
RP Vickers, MH (corresponding author), Univ Auckland, Liggins Inst, Auckland 1142, New Zealand.
EM m.vickers@auckland.ac.nz
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NR 109
TC 57
Z9 68
U1 0
U2 8
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2314-6133
EI 2314-6141
J9 BIOMED RES INT
JI Biomed Res. Int.
PY 2015
VL 2015
AR 437107
DI 10.1155/2015/437107
PG 12
WC Biotechnology & Applied Microbiology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Research & Experimental Medicine
GA CJ4GU
UT WOS:000355443600001
PM 26090409
OA Green Published, hybrid, Green Submitted
DA 2025-06-11
ER

PT J
AU Kotani, K
AF Kotani, Kazuhiko
TI An update on serum amyloid A-LDL and its potential use for dyslipidemic
   patients receiving lipid-modulating treatment
SO CLINICAL LIPIDOLOGY
LA English
DT Review
DE atherosclerosis; eicosapentaenoic acid; fibrate; lipid disorder; statin
ID LOW-DENSITY-LIPOPROTEIN; C-REACTIVE PROTEIN; METABOLIC SYNDROME;
   EICOSAPENTAENOIC ACID; HYPERCHOLESTEROLEMIC PATIENTS; OXIDATIVE STRESS;
   ASSOCIATION; STATINS; DISEASE; RISK
AB LDL is modified under pathological conditions associated with inflammation and oxidative stress. Serum amyloid A-LDL (SAA-LDL) is considered a possible marker of atherosclerotic diseases. The present article reviews the clinical studies of SAA-LDL in dyslipidemic patients being treated with lipid-modulating drugs. Although limited studies are currently available, a therapeutic reduction of SAA-LDL levels could be seen following treatment of dyslipidemic patients with eicosapentaenoic acid, fibrates and statins. The SAA-LDL level may potentially be used to monitor the effectiveness of treatment in these patients, while the clinical utility of measuring the SAA-LDL level has yet to be established in large prospective clinical trials. Future studies are warranted to confirm the clinical relevance of SAA-LDL.
C1 Jichi Med Univ, Dept Clin Lab Med, Shimotsuke, Tochigi 3290498, Japan.
C3 Jichi Medical University
RP Kotani, K (corresponding author), Jichi Med Univ, Dept Clin Lab Med, 3311-1 Yakushiji, Shimotsuke, Tochigi 3290498, Japan.
EM kazukotani@jichi.ac.jp
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NR 37
TC 0
Z9 0
U1 1
U2 3
PU FUTURE MEDICINE LTD
PI LONDON
PA UNITEC HOUSE, 3RD FLOOR, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON, N3
   1QB, ENGLAND
SN 1758-4299
EI 1758-4302
J9 CLIN LIPIDOL
JI Clin. Lipidol.
PD AUG
PY 2013
VL 8
IS 4
BP 419
EP 423
DI 10.2217/CLP.13.41
PG 5
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 197ZJ
UT WOS:000322891100011
DA 2025-06-11
ER

PT J
AU Smith, DI
   Sakarcan, E
   Adams-Campbell, L
   Dash, C
AF Smith, Danyel I.
   Sakarcan, Eren
   Adams-Campbell, Lucile
   Dash, Chiranjeev
TI Diet Quality, Metabolic Syndrome, and Nativity Status: Elucidating
   Metabolic Advantage and Disadvantage Among Non-US-Native and US-Native
   Populations Using NHANES Data (2013-2018)
SO NUTRIENTS
LA English
DT Article
DE metabolic syndrome; nativity status; diet quality; health disparities
ID CHRONIC STRESS; HEALTH; IMMIGRATION; WOMEN
AB Background/Objectives: Nutrient-poor diet quality is a major driver of the global burden of metabolic syndrome (MetS). The US ranks among the lowest in diet quality and has the highest rate of immigration, which may present unique challenges for non-US-native populations who experience changes in access to health-promoting resources. This study examined associations among MetS, nativity status, diet quality, and interaction effects of race-ethnicity among Hispanic, Asian, Black, and White US-native and non-US-native adults. Methods: We examined data from 5482 adult participants (>= 20 years of age) in the National Health and Nutrition Examination Survey (2013-2018). MetS (per the ATP III panel guidelines) was assessed continuously (MetS z-score) and dichotomously. Dietary recalls were used to compute HEI-2015 scores. Nativity status and sociodemographic variables were assessed. Age-adjusted and multivariate-adjusted logistic regressions were conducted to examine the associations between nativity status and MetS and interaction effects by race-ethnicity. Results: Non-US-native participants displayed more guideline-adherent diet quality (55.23% vs. 49.38%, p < 0.001) compared to their US-native counterparts-even when stratified by racial-ethnic groups. US-native participants had larger waist circumferences and elevated triglyceride levels. Non-US-native Black Americans had a 60% lower risk of having MetS even after adjusting for diet quality (OR: 0.39, 95% CI: 0.17, 0.88) compared to their US-native counterparts. For MetS components, non-US-native Asian participants reported a lower risk for dyslipidemia, while non-US-native multiracial participants had higher triglycerides. Conclusions: Non-US-native groups display better diet quality compared to their US-native counterparts. However, the findings suggest that diet quality alone does not account for nativity-related cardiometabolic disparities, particularly in US-native Black Americans, thus necessitating interventions targeting the social determinants of health.
C1 [Smith, Danyel I.; Adams-Campbell, Lucile; Dash, Chiranjeev] Georgetown Univ, Georgetown Lombardi Comprehens Canc Ctr, Off Minor Hlth & Hlth Dispar Res, 1010 New Jersey Ave SE, Washington, DC 20003 USA.
   [Sakarcan, Eren] Univ South Carolina, Sch Med, 6311 Garners Ferry Rd, Columbia, SC 29209 USA.
C3 Georgetown University; University of South Carolina System; University
   of South Carolina Columbia
RP Smith, DI (corresponding author), Georgetown Univ, Georgetown Lombardi Comprehens Canc Ctr, Off Minor Hlth & Hlth Dispar Res, 1010 New Jersey Ave SE, Washington, DC 20003 USA.
EM ds1924@georgetown.edu; eren.sakarcan@uscmed.sc.edu; lla9@georgetown.edu;
   cd422@georgetown.edu
OI Smith, Danyel/0000-0002-2154-9161; Sakarcan, Eren/0009-0007-0747-0354;
   Adams-Campbell, Lucile/0000-0002-3444-3884
FU National Cancer Institute [T32 CA261787]; T32 postdoctoral fellowship
   from the National Cancer Institute
FX The preparation of this manuscript was supported by a T32 postdoctoral
   fellowship from the National Cancer Institute awarded to Dr. Smith (T32
   CA261787).
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NR 35
TC 0
Z9 0
U1 2
U2 2
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JAN
PY 2025
VL 17
IS 2
AR 215
DI 10.3390/nu17020215
PG 15
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA T6A2Y
UT WOS:001405801300001
PM 39861345
OA gold
DA 2025-06-11
ER

PT J
AU El-Sayed, SS
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AF El-Sayed, Shaimaa S.
   Rezq, Samar
   Alsemeh, Amira Ebrahim
   Mahmoud, Mona F.
TI Moxonidine ameliorates cardiac injury in rats with metabolic syndrome by
   regulating autophagy
SO LIFE SCIENCES
LA English
DT Article
DE Autophagy; Imidazoline-1 receptor; Metabolic syndrome; Heart; Apoptosis
ID INSULIN-RESISTANCE; CARDIOVASCULAR-DISEASE; OXIDATIVE STRESS;
   IMIDAZOLINE RECEPTORS; INDUCED HYPERTENSION; GLUCOSE-HOMEOSTASIS;
   SYMPATHETIC TONE; LIPID PROFILE; OBESITY; HEART
AB Aims: Reduced cardiac autophagy, ischemic injury, sympathetic overactivity, and apoptosis all contribute to metabolic syndrome (MetS)-associated cardiovascular risks. NR4A2, an orphan nuclear receptor NR4A family member, induces autophagy while suppressing apoptosis in myocardial infarction. Moxonidine, a sym-pathoinhibitor imidazoline1 receptor (I1R) agonist, has beneficial metabolic and hemodynamic effects; however, whether autophagy and/or NR4A2 signaling are involved in moxonidine's cardiovascular effects via I1R activation, is unknown, and is the aim of this study. Materials and methods: To induce MetS, rats were fed 3 % salt in their diet and 10 % fructose in their drinking water for 12 weeks. MetS-rats were given either moxonidine (6 mg/kg/day, gavage), efaroxan (I1R antagonist, 0.6 mg/kg/day, i.p), both treatments, or vehicles for the last two weeks. Blood pressure, lipid profile, and gly-cemic control were evaluated. Histopathological examination, circulating cardiac troponin I (c-TnI), proin-flammatory interleukin-6 (IL-6), apoptosis (active caspase-3 and Fas-immunostaining), interstitial fibrosis [transforming growth factor-beta 1 (TGF-beta 1), Mallory's trichrome staining], and extracellular matrix remodeling [matrix metalloproteinase-9 (MMP-9)], were used to assess cardiac pathology. Cardiac NR4A2 and its down-stream factor, p53, as well as autophagic flux markers, SQSTM1/p62, LC3, and Beclin-1 were also determined. Key findings: Moxonidine significantly ameliorated MetS-induced metabolic and hemodynamic derangements and the associated cardiac pathology. Moxonidine restored NR4A2 and p53 myocardial levels and enhanced auto-phagic flux via modulating SQSTM1/p62, LC3, and Beclin-1. Efaroxan reversed the majority of the moxonidine-induced improvements. Significance: The current study suggests that autophagy modulation via I1R activation is involved in moxonidine-mediated cardiac beneficial effects in MetS.
C1 [El-Sayed, Shaimaa S.; Rezq, Samar; Mahmoud, Mona F.] Zagazig Univ, Fac Pharm, Dept Pharmacol & Toxicol, Zagazig, Egypt.
   [Alsemeh, Amira Ebrahim] Zagazig Univ, Fac Med, Dept Human Anat & Embryol, Zagazig, Egypt.
   [Rezq, Samar] Zagazig Univ, Fac Pharm, Dept Pharmacol & Toxicol, Zagazig 44519, Egypt.
   [Rezq, Samar] UMMC, Dept Cell & Mol Biol, Jackson, MS 39216 USA.
C3 Egyptian Knowledge Bank (EKB); Zagazig University; Egyptian Knowledge
   Bank (EKB); Zagazig University; Egyptian Knowledge Bank (EKB); Zagazig
   University; University of Mississippi Medical Center
RP Rezq, S (corresponding author), Zagazig Univ, Fac Pharm, Dept Pharmacol & Toxicol, Zagazig 44519, Egypt.; Rezq, S (corresponding author), UMMC, Dept Cell & Mol Biol, Jackson, MS 39216 USA.
EM srezq@umc.edu
RI El-Sayed, Shaimaa/HJB-0866-2022; Alsemeh, Amira/LWH-9728-2024; Rezq,
   Samar/AAL-6255-2020; Mahmoud, Mona/Q-8851-2019
OI El-Sayed, Shaimaa/0000-0003-2314-6144
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NR 97
TC 6
Z9 6
U1 0
U2 5
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0024-3205
EI 1879-0631
J9 LIFE SCI
JI Life Sci.
PD JAN 1
PY 2023
VL 312
AR 121210
DI 10.1016/j.lfs.2022.121210
EA NOV 2022
PG 11
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA 6S5HT
UT WOS:000893018700003
PM 36410408
DA 2025-06-11
ER

PT J
AU Alkhaldi, MM
   Aldisi, D
   Elshafie, MM
   Alghamdi, MN
   Sabico, S
   Al-Daghri, NM
AF Alkhaldi, Mona M.
   Aldisi, Dara
   Elshafie, Mona M.
   Alghamdi, Mosfer N.
   Sabico, Shaun
   Al-Daghri, Nasser M.
TI Antioxidant status and dietary pattern of Arab adults with and without
   metabolic syndrome
SO JOURNAL OF KING SAUD UNIVERSITY SCIENCE
LA English
DT Article
DE Metabolic syndrome; Antioxidants; Arabs; Diet; Liver enzyme
ID OXIDATIVE STRESS; LIVER; ENZYMES; MARKERS; PROTEIN; WOMEN; ACID; MEN;
   SEX
AB Background: Metabolic syndrome (MetS) is a major health problem in the Saudi Arabian population. The aim of this study was to determine the status of antioxidant enzymes, liver enzymes, and intake of selected nutrients in subjects with MetS among Saudi adults in Taif city. Methods: In this case-control study, a total of 104 subjects (76 with MetS and 28 controls) were recruited. Demographic data was obtained from the participants. Evaluation of anthropometric variables, glucose, lipid profiles, antioxidant enzymes and liver profile were performed. Dietary intake was evaluated through FFQ. Results: A positive correlation was observed between protein intake and alanine transaminase (ALT) among subjects with MetS (R = 0.33; p < 0.01). In all subjects, the macronutrients were significant pre-dictors of body mass index [carbohydrates (p = 0.66; p < 0.001) followed by fats (p = 0.43; p = 0.003) and protein (p = 0.25; p = 0.04). Fat intake was the most significant predictor for waist circumference (p = 0.46; p = 0.001) followed by protein (p = 0.30; p = 0.01) and carbohydrates (p = 0.49; p = 0.02). Linoleic acid intake had a significant protective effect on diastolic blood pressure (p = 0.027). No signif-icant differences were elicited in antioxidants, liver enzymes and dietary intake between MetS and con-trols. Conclusion: Among the antioxidant and liver enzymes, only ALT was significantly associated with protein intake among MetS subjects. Moderate consumption of this macronutrient is recommended among sub-jects with MetS to prevent liver injury. Further studies are needed using a longitudinal design and with larger sample size to confirm present findings. (c) 2021 The Author(s). Published by Elsevier B.V. on behalf of King Saud University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
C1 [Alkhaldi, Mona M.; Alghamdi, Mosfer N.] Alhada Armed Forces Hosp, At Taif, Saudi Arabia.
   [Aldisi, Dara; Elshafie, Mona M.] King Saud Univ, Coll Appl Med Sci, Dept Community Hlth Sci, Riyadh, Saudi Arabia.
   [Sabico, Shaun; Al-Daghri, Nasser M.] Coll Sci, Chair Biomarkers Chron Dis, Dept Biochem, Riyadh, Saudi Arabia.
C3 Al Hada Armed Forces Hospital; King Saud University
RP Aldisi, D (corresponding author), King Saud Univ, Coll Appl Med Sci, Dept Community Hlth Sci, Riyadh, Saudi Arabia.
EM daldisi@ksu.edu.sa
RI Al-Daghri, Nasser/A-8360-2011; Aldisi, Dara/HPG-0366-2023; Sabico,
   Shaun/C-9086-2011
OI Al-Daghri, Nasser/0000-0001-5472-1725; Sabico, Shaun/0000-0002-5248-2350
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NR 40
TC 1
Z9 1
U1 0
U2 0
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1018-3647
EI 2213-686X
J9 J KING SAUD UNIV SCI
JI J. King Saud Univ. Sci.
PD OCT
PY 2021
VL 33
IS 7
AR 101561
DI 10.1016/j.jksus.2021.101561
EA AUG 2021
PG 7
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA WG1VJ
UT WOS:000706785700011
OA gold
DA 2025-06-11
ER

PT J
AU Moriyama, K
AF Moriyama, Kengo
TI Low-density Lipoprotein Subclasses are Associated with Serum Uric Acid
   Levels
SO CLINICAL LABORATORY
LA English
DT Article
DE uric acid; small; dense low-density lipoprotein cholesterol;
   malondialdehyde-modified low-density lipoprotein; metabolic syndrome
ID CORONARY-ARTERY-DISEASE; MALONDIALDEHYDE-MODIFIED LDL; TYPE-2
   DIABETES-MELLITUS; METABOLIC-SYNDROME; RISK-FACTOR; INSULIN SENSITIVITY;
   OXIDATIVE STRESS; HYPERURICEMIA; PARTICLES; MORTALITY
AB Background: Levels of uric acid (UA) and low-density lipoprotein (LDL) subclasses are both associated with coronary heart disease and metabolic syndrome (MetS). However, the relationship between UA and LDL subclasses is not well understood.
   Methods: Subjects included 633 Japanese subjects not receiving medication for hyperuricemia, diabetes mellitus, dyslipidemia, or chronic renal disease who underwent an annual health examination that included determination of small, dense low-density lipoprotein cholesterol (sdLDL-C) and malondialdehyde-modified low-density lipoprotein (MDA-LDL) levels.
   Results: Serum UA exhibited a positive correlation with both sdLDL-C and MDA-LDL (r = 0.335 and 0.339, respectively). Since sdLDL-C and MDA-LDL show strong positive association, sdLDL-C and MDA-LDL were used as separate explanatory variables in multiple linear regression analysis. Male gender, waist circumference (WC), high-density lipoprotein cholesterol (HDL-C), logarithmic transformed triglyceride (TG) [ln(TG)], and MDA-LDL as a group were associated with serum UA. Similarly, male gender, body mass index (BMI), ln(TG), and sdLDL-C as a group were associated with serum UA. These results further supported that both MDA-LDL and sdLDL-C levels were positively correlated with serum UA levels. Evaluation of subjects' characteristics according to tertile UA values (tertile 1, < 5.0 mg/dL; tertile 2, 5.0 - < 6.3 mg/dL; tertile 3, >= 6.3 mg/dL) indicated that MDALDL and sdLDL-C levels gradually increased with increasing UA levels. Additionally, the upper third UA tertile was associated with the worst metabolic profile based on BMI, WC, blood pressure, fasting plasma glucose, fasting immunoreactive insulin, homeostasis model assessment insulin resistance, TG, HDL-C, and the number of MetS components.
   Conclusions: Both LDL particle size and oxidized LDL were associated with serum UA levels in Japanese subjects.
C1 [Moriyama, Kengo] Tokai Univ, Sch Med, Dept Clin Hlth Sci, Ishikawa Machi 1838, Hachioji, Tokyo 1920032, Japan.
C3 Tokai University
RP Moriyama, K (corresponding author), Tokai Univ, Sch Med, Dept Clin Hlth Sci, Ishikawa Machi 1838, Hachioji, Tokyo 1920032, Japan.
EM osaru3moving@gmail.com
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NR 38
TC 3
Z9 3
U1 2
U2 8
PU CLIN LAB PUBL
PI HEIDELBERG
PA IM BREITSPIEL 15, HEIDELBERG, D-69126, GERMANY
SN 1433-6510
J9 CLIN LAB
JI Clin. Lab.
PY 2018
VL 64
IS 7-8
BP 1137
EP 1144
DI 10.7754/Clin.Lab.2018.180108
PG 8
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA GR5JC
UT WOS:000442664700005
PM 30146836
DA 2025-06-11
ER

PT J
AU Radzinskii, VE
   Kuznetsova, IV
   Uspenskaya, YB
   Repina, NB
   Gusak, YK
   Zubova, OM
   Burchakov, DI
   Osmakova, AA
AF Radzinskii, V. E.
   Kuznetsova, I. V.
   Uspenskaya, Y. B.
   Repina, N. B.
   Gusak, Y. K.
   Zubova, O. M.
   Burchakov, D. I.
   Osmakova, A. A.
TI Treatment of climacteric symptoms with an ammonium succinate-based
   dietary supplement: a randomized, double-blind, placebo-controlled trial
SO GYNECOLOGICAL ENDOCRINOLOGY
LA English
DT Article
DE Ammonium succinate; menopause; menopausal symptoms treatment;
   mitochondrial dysfunction; vasomotor and psychosomatic menopause
   symptoms
ID HOT FLASHES; MITOCHONDRIAL-FUNCTION; POSTMENOPAUSAL WOMEN; MENOPAUSAL
   SYMPTOMS; VASOMOTOR SYMPTOMS; METABOLIC SYNDROME; HORMONE-THERAPY;
   ESTROGEN; MIDLIFE; PERIMENOPAUSAL
AB Peri- and postmenopausal women commonly suffer from climacteric symptoms. We evaluated the effectiveness and safety of dietary supplement Amberen to relieve vasomotor and psychosomatic symptoms during the course of a 3-month, randomized, double-blind, placebo-controlled study. General clinical assessment, evaluation using the Greene climacteric test and Spielberger-Hanin test, determination of plasma levels of gonadotropins, estradiol, leptin and apolipoproteins were used to evaluate 42-60-year-old women with vasomotor and psychosomatic menopausal symptoms. One hundred and twenty-five women were enrolled in the study and randomized between two groups. Based on the Greene test results, there was a statistically significant improvement (?<0.05) in 13 out of 21 menopausal symptoms in women who took Amberen. During the course and by the end of the study, patients showed statistically significant changes in the levels of estradiol, gonadotropins and leptin, and decreases in body weight and waist circumference. Spielberger-Hanin test showed that Amberen stabilizes patients' psychological state with a statistically significant decrease in anxiety, increased stress resistance and improved adaptability. Comparative analysis of the vital signs measurements, blood tests and urinalysis did not show any negative effects of Amberen on the patients. Our findings indicate that Amberen can be considered a method of choice to relief mild/moderate climacteric symptoms.
C1 [Radzinskii, V. E.; Osmakova, A. A.] Peoples Friendship Univ Russia, Inst Med, Dept Obstet & Gynecol, Moscow, Russia.
   [Kuznetsova, I. V.; Uspenskaya, Y. B.; Burchakov, D. I.] IM Sechenov First Moscow State Med Univ, Womens Hlth Res Inst, Res Ctr, Elanskogo St 2,Bld 1, Moscow 119991, Russia.
   [Repina, N. B.; Gusak, Y. K.] Ryazan State Med Univ, Dept Obstet & Gynecol, Ryazan, Russia.
   [Zubova, O. M.] Moscow MV Lomonosov State Univ, Dept Therapy, Moscow, Russia.
C3 Peoples Friendship University of Russia; Sechenov First Moscow State
   Medical University; Ryazan State Medical University; Lomonosov Moscow
   State University
RP Kuznetsova, IV (corresponding author), IM Sechenov First Moscow State Med Univ, Womens Hlth Res Inst, Res Ctr, Elanskogo St 2,Bld 1, Moscow 119991, Russia.
EM ms.smith.ivk@gmail.com
RI Burchakov, Denis/H-9237-2019; Uspenskaya, Yulia/C-7531-2019
CR [Anonymous], 2012, MENOPAUSE, V19, P257, DOI 10.1097/gme.0b013e31824b970a
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NR 31
TC 8
Z9 8
U1 0
U2 10
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0951-3590
EI 1473-0766
J9 GYNECOL ENDOCRINOL
JI Gynecol. Endocrinol.
PD OCT
PY 2016
VL 32
SU 2
BP 64
EP 68
DI 10.1080/09513590.2016.1232686
PG 5
WC Endocrinology & Metabolism; Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Obstetrics & Gynecology
GA EA6AH
UT WOS:000386706400017
PM 27759458
OA hybrid
DA 2025-06-11
ER

PT J
AU Guo, Q
   Zhao, YC
   Xue, T
   Zhang, JF
   Duan, XL
AF Guo, Qian
   Zhao, Yuchen
   Xue, Tao
   Zhang, Junfeng
   Duan, Xiaoli
TI Association of PM2.5 and Its Chemical Compositions with
   Metabolic Syndrome: A Nationwide Study in Middle-Aged and Older Chinese
   Adults
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Article
DE particulate matter; metabolic syndrome; adults; composition;
   cross-sectional
ID FINE PARTICULATE MATTER; LONG-TERM EXPOSURE; AIR-POLLUTION; OXIDATIVE
   STRESS; HEALTH; CONSTITUENTS; INFLAMMATION; AEROSOLS; RISK
AB Studies on the association of PM2.5 and its compositions with metabolic syndrome (MetS) were limited, and it was unclear which was the most hazardous composition. In this study, we aimed to investigate the association between PM2.5 and its compositions with MetS and identified the most hazardous composition. In this study, we included 13,418 adults over 45 years across 446 communities from 150 counties of 28 provinces in nationwide China in 2015. MetS was defined based on the five indicators of the Joint Interim Societies, including: blood pressure (SBP (systolic blood pressure) and DBP (diastolic blood pressure)); fasting blood glucose (FBG); fasting triglyceride (FTG); high density lipoprotein cholesterol (HDL-C); and waist circumference (WC). We used chemical transport models to estimate the concentration of PM2.5 and its compositions, including black carbon, ammonium, nitrate, organic matter, and sulfate. We used a generalized linear regression model to examine the association of PM2.5 and its compositions with MetS. In this study, we observed that the average age was 61.40 (standard deviation (SD): 9.59). Each IQR (29.76 mu g/m(3)) increase in PM2.5 was associated with a 1.27 (95% CI: 1.17, 1.37) increase in the odds for MetS. We indicated that black carbon showed stronger associations than other compositions. The higher associations were observed among women, participants aged less than 60 years, who lived in urban areas and in the Northeast, smokers, drinkers, and the obese populations. In conclusion, our findings identified the most harmful composition and sensitive populations and regions that required attention, which would be helpful for policymakers.
C1 [Guo, Qian; Zhao, Yuchen; Duan, Xiaoli] Univ Sci & Technol Beijing, Sch Energy & Environm Engn, Beijing 100083, Peoples R China.
   [Xue, Tao] Peking Univ, Key Lab Reprod Hlth, Inst Reprod & Child Hlth, Minist Hlth, Beijing 100083, Peoples R China.
   [Xue, Tao] Peking Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing 100083, Peoples R China.
   [Zhang, Junfeng] Duke Univ, Nicholas Sch Environm & Global Hlth Inst, Durham, NC 27708 USA.
   [Zhang, Junfeng] Duke Kunshan Univ, Kunshan 215316, Peoples R China.
C3 University of Science & Technology Beijing; Peking University; Peking
   University; Duke University; Duke Kunshan University
RP Duan, XL (corresponding author), Univ Sci & Technol Beijing, Sch Energy & Environm Engn, Beijing 100083, Peoples R China.
EM jasmine@ustb.edu.cn
RI zhang, junfeng/JHT-7871-2023; Xue, Tao/R-4763-2018
OI Zhang, Junfeng/0000-0003-3759-6672; Duan, Xiaoli/0000-0002-7424-9656;
   Xue, Tao/0000-0002-7045-2307
FU National Natural Science Foundation of China [41977374]
FX This research was funded by National Natural Science Foundation of
   China, grant number 41977374.
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NR 53
TC 8
Z9 9
U1 4
U2 28
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD NOV
PY 2022
VL 19
IS 22
AR 14671
DI 10.3390/ijerph192214671
PG 11
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA 6K1PJ
UT WOS:000887283000001
PM 36429390
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Smieszek, A
   Kornicka, K
   Szlapka-Kosarzewska, J
   Androvic, P
   Valihrach, L
   Langerova, L
   Rohlova, E
   Kubista, M
   Marycz, K
AF Smieszek, Agnieszka
   Kornicka, Katarzyna
   Szlapka-Kosarzewska, Jolanta
   Androvic, Peter
   Valihrach, Lukas
   Langerova, Lucie
   Rohlova, Eva
   Kubista, Mikael
   Marycz, Krzysztof
TI Metformin Increases Proliferative Activity and Viability of Multipotent
   Stromal Stem Cells Isolated from Adipose Tissue Derived from Horses with
   Equine Metabolic Syndrome
SO CELLS
LA English
DT Article
DE adipose-derived stromal cells; equine metabolic syndrome; metformin
ID INSULIN-RESISTANCE; OSTEOGENIC DIFFERENTIATION; ANTIDIABETIC DRUG;
   PROGENITOR CELLS; IN-VITRO; EXPRESSION; AUTOPHAGY; WNT; MICRORNAS;
   APOPTOSIS
AB In this study, we investigated the influence of metformin (MF) on proliferation and viability of adipose-derived stromal cells isolated from horses (EqASCs). We determined the effect of metformin on cell metabolism in terms of mitochondrial metabolism and oxidative status. Our purpose was to evaluate the metformin effect on cells derived from healthy horses (EqASC(HE)) and individuals affected by equine metabolic syndrome (EqASC(EMS)). The cells were treated with 0.5 M MF for 72 h. The proliferative activity was evaluated based on the measurement of BrdU incorporation during DNA synthesis, as well as population doubling time rate (PDT) and distribution of EqASCs in the cell cycle. The influence of metformin on EqASC viability was determined in relation to apoptosis profile, mitochondrial membrane potential, oxidative stress markers and BAX/BCL-2 mRNA ratio. Further, we were interested in possibility of metformin affecting the Wnt3a signalling pathway and, thus, we determined mRNA and protein level of WNT3A and -catenin. Finally, using a two-tailed RT-qPCR method, we investigated the expression of miR-16-5p, miR-21-5p, miR-29a-3p, miR-140-3p and miR-145-5p. Obtained results indicate pro-proliferative and anti-apoptotic effects of metformin on EqASCs. In this study, MF significantly improved proliferation of EqASCs, which manifested in increased synthesis of DNA and lowered PDT value. Additionally, metformin improved metabolism and viability of cells, which correlated with higher mitochondrial membrane potential, reduced apoptosis and increased WNT3A/-catenin expression. Metformin modulates the miRNA expression differently in EqASC(HE) and EqASC(EMS). Metformin may be used as a preconditioning agent which stimulates proliferative activity and viability of EqASCs.
C1 [Smieszek, Agnieszka; Kornicka, Katarzyna; Szlapka-Kosarzewska, Jolanta; Marycz, Krzysztof] Univ Environm & Life Sci, Fac Biol & Anim Sci, Dept Expt Biol, PL-50375 Wroclaw, Poland.
   [Androvic, Peter; Valihrach, Lukas; Rohlova, Eva; Kubista, Mikael] CAS, Inst Biotechnol, Gene Express Lab, Biocev, Vestec 25250, Czech Republic.
   [Androvic, Peter] Palacky Univ, Lab Growth Regulators, Fac Sci, Olomouc 78371, Czech Republic.
   [Langerova, Lucie] Gene Core BIOCEV, Prumyslova 595, Vestec 25250, Czech Republic.
   [Rohlova, Eva] Charles Univ Prague, Dept Anthropol & Human Genet, Fac Sci, Prague 12843, Czech Republic.
   [Kubista, Mikael] TATAA Bioctr AB, S-41103 Gothenburg, Sweden.
   [Marycz, Krzysztof] Justus Liebig Univ, Equine Clin Equine Surg, Fac Vet Med, D-35392 Giessen, Germany.
C3 Wroclaw University of Environmental & Life Sciences; Czech Academy of
   Sciences; Institute of Biotechnology of the Czech Academy of Sciences;
   Palacky University Olomouc; Charles University Prague; Justus Liebig
   University Giessen
RP Smieszek, A (corresponding author), Univ Environm & Life Sci, Fac Biol & Anim Sci, Dept Expt Biol, PL-50375 Wroclaw, Poland.
EM agnieszka.smieszek@upwr.edu.pl; kornicka.katarzyna@gmail.com;
   jolanta.szlapka@upwr.edu.pl; peter.androvic@ibt.cas.cz;
   lukas.valihrach@ibt.cas.cz; lucie.langerova@ibt.cas.cz;
   eva.rohlova@ibt.cas.cz; mikael.kubista@ibt.cas.cz;
   krzysztof.marycz@upwr.edu.pl
RI Kubista, Mikael/A-5689-2008; Valihrach, Lukas/H-4368-2014; Langerova,
   Lucie/G-6385-2014; Rohlova, Eva/AAB-3009-2020; Smieszek,
   Agnieszka/A-4887-2017
OI Smieszek, Agnieszka/0000-0002-7314-9821; Valihrach,
   Lukas/0000-0002-6704-4337
FU National Science Centre in Poland [2016/21/B/NZ7/01111,
   2018/29/B/NZ7/02662]; Czech Science Foundation [P303/18/21942S, RVO
   86652036, BIOCEV CZ.1.05/1.1.00/02.0109];  [0019/SDU/2018/18]
FX This project is financed in the framework of grant entitled "Modulation
   mitochondrial metabolism and dynamics and targeting DNA methylation of
   adipose derived mesenchymal stromal stem cell (ASC) using RES and
   5-azacytydin as a therapeutic strategy in the course of EMS" (Grant no.
   2016/21/B/NZ7/01111) and "Inhibition of tyrosine phosphatase as a
   strategy to enhance insulin sensitivity through activation of chaperone
   mediated autophagy and amelioration of inflammation and cellular stress
   in the liver of equine metabolic syndrome (EMS) horses" (Grant no.
   2018/29/B/NZ7/02662) financed by The National Science Centre in Poland.
   The project is financed under the program of the Minister of Science and
   Higher Education "Strategy of Excellence-University of Research" in
   2018-2019 project number 0019/SDU/2018/18 in the amount of PLN 700000.
   This study is supported by following grants: Czech Science Foundation
   P303/18/21942S; RVO 86652036; BIOCEV CZ.1.05/1.1.00/02.0109.
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NR 82
TC 24
Z9 24
U1 1
U2 14
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2073-4409
J9 CELLS-BASEL
JI Cells
PD FEB
PY 2019
VL 8
IS 2
AR 80
DI 10.3390/cells8020080
PG 20
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA HO4MF
UT WOS:000460896000002
PM 30678275
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Gaudreault, V
   Després, JP
   Rhéaume, C
   Bergeron, J
   Alméras, N
   Tremblay, A
   Poirier, P
AF Gaudreault, Valerie
   Despres, Jean-Pierre
   Rheaume, Caroline
   Bergeron, Jean
   Almeras, Natalie
   Tremblay, Angelo
   Poirier, Paul
TI Exercise-induced exaggerated blood pressure response in men with the
   metabolic syndrome: the role of the autonomous nervous system
SO BLOOD PRESSURE MONITORING
LA English
DT Article
DE blood pressure; insulin resistance; metabolic syndrome; heart rate
   variability; exercise
ID INSULIN-RESISTANCE; BAROREFLEX FUNCTION; NORMOTENSIVE MEN; RISK;
   HYPERTENSION; CHOLESTEROL; MORTALITY; OBESITY; STRESS; PLASMA
AB Introduction
   Abnormalities in the autonomic nervous system in the presence of insulin resistance may be involved in the pathophysiology of obesity-associated hypertension. We evaluated the association between exercise-induced exaggerated blood pressure (BP) response [exercise-induced hypertension (EIH)] and heart rate variability (HRV) and insulin resistance in men with metabolic syndrome (MetS).
   Materials and methods
   Ninety-eight resting normotensive men with MetS underwent a maximal symptom-limited treadmill test. BP was measured after a 5-min rest (anticipatory BP) every 3 min during exercise and during the recovery period. EIH was defined as maximum systolic BP of 220 mmHg or higher and/or maximum diastolic BP of 100 mmHg or higher. Insulin resistance was estimated using HOMA-IR. Each participant underwent a 3-h oral glucose tolerance test (OGTT). HRV was derived from a 24-h Holter.
   Results
   About half of the participants (52%) presented EIH. Resting BPs at baseline were 125 +/- 10/83 +/- 7 mmHg in participants with EIH and 120 +/- 9/80 +/- 6 mmHg (P=0.01) in the group with normal BP response to exercise. OGTT glucose levels were higher in the group with EIH (all P < 0.04) as well as HOMA-IR compared with participants with normal BP response to exercise (P=0.03). In terms of HRV, 24-h standard deviation of the RR intervals (SDNN) was lower in participants with EIH (P=0.04) as well as 24-h daytime and night-time high frequency and low frequency (P < 0.05).
   Conclusion
   Normotensive men with MetS but with EIH have greater insulin resistance as well as lower HRV parasympathetic and sympathetic indices. These features may be involved in the pathophysiology of EIH.
C1 [Gaudreault, Valerie; Despres, Jean-Pierre; Rheaume, Caroline; Almeras, Natalie; Tremblay, Angelo; Poirier, Paul] Quebec City Heart & Lung Inst, Dept Cardiol, Quebec City, PQ G1V 4G5, Canada.
   [Bergeron, Jean] Univ Laval, Res Ctr, Dept Lipidol, Quebec City, PQ, Canada.
   [Gaudreault, Valerie; Poirier, Paul] Univ Laval, Fac Pharm, Quebec City, PQ, Canada.
   [Despres, Jean-Pierre; Rheaume, Caroline; Bergeron, Jean; Almeras, Natalie; Tremblay, Angelo] Univ Laval, Fac Med, Quebec City, PQ G1K 7P4, Canada.
C3 Quebec Heart & Lung Institute; Laval University; Laval University; Laval
   University
RP Poirier, P (corresponding author), Quebec City Heart & Lung Inst, Dept Cardiol, 2725 Chemin Ste Foy, Quebec City, PQ G1V 4G5, Canada.
EM paul.poirier@criucpq.ulaval.ca
RI Poirier, Paul/KFS-2253-2024; Rheaume, Caroline/GLS-9147-2022
OI Rheaume, Caroline/0000-0002-1863-4410
FU Canadian Diabetes Association; FRSQ
FX This work was supported by an operating grant from the Canadian Diabetes
   Association to P. Poirier, who holds an FRSQ chercheur-clinicien senior
   award.
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U1 0
U2 16
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1359-5237
EI 1473-5725
J9 BLOOD PRESS MONIT
JI Blood Press. Monit.
PD OCT
PY 2013
VL 18
IS 5
BP 252
EP 258
DI 10.1097/MBP.0b013e3283646f59
PG 7
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 219RZ
UT WOS:000324527900003
PM 23903294
DA 2025-06-11
ER

PT J
AU Puchau, B
   Zulet, MA
   Urtiaga, G
   Navarro-Blasco, I
   Martínez, JA
AF Puchau, Blanca
   Zulet, Maria A.
   Urtiaga, Goizane
   Navarro-Blasco, Inigo
   Alfredo Martinez, J.
TI Asymmetric dimethylarginine association with antioxidants intake in
   healthy young adults: a role as an indicator of metabolic syndrome
   features
SO METABOLISM-CLINICAL AND EXPERIMENTAL
LA English
DT Article
ID OXIDE SYNTHASE INHIBITOR; ENDOTHELIAL DYSFUNCTION; INSULIN-RESISTANCE;
   DEPENDENT PATHWAY; OXIDATIVE STRESS; ADIPOSE-TISSUE; PROTEIN; OBESITY;
   PLASMA; INFLAMMATION
AB The purpose of this study was to evaluate the potential associations between serum asymmetric dimethylarginine (ADMA) and several anthropometric, biochemical, and lifestyle features in healthy young adults, emphasizing on the putative effects of the antioxidant intake on ADMA concentrations. Anthropometric and blood pressure measurements as well as lifestyle features and antioxidant intake were analyzed in 93 healthy Young adults aged 18 to 34 years. Fasting blood samples were collected for the measurement of glucose, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triacylglycerols, and ADMA concentrations, as well as erythrocyte glutathione peroxidase activity. Nail samples were collected for the analysis of selenium and zinc concentrations. Values of body mass index (P = .004), waist circumference (P = .008), waist-to-height ratio (P = .046), systolic blood pressure (P < .001), serum glucose (P < .001) and nail selenium (P = .004) and zinc (P = .018) were significantly different between Subjects with scrum ADMA higher and lower than the median (Cutoff, 458 nmol/L). Furthermore, ADMA showed a positive association with several adiposity markers Such as body weight (P < .001), body mass index (P < .001), waist circumference (P = .006), waist-to-height ratio (P = .020), body fat mass (P = .001), systolic blood pressure (P = .001), and serum glucose (P < .001), whereas erythrocyte glutathione peroxidase activity (P = .021) and nail selenium (P = .040) and Zinc Values (P = .013) were statistically significant negative predictors of ADMA concentrations, In conclusion, ADMA seems to be related with selenium and zinc status and several anthropometric and biochemical measurements linked to metabolic syndrome in apparently healthy young adults. These findings support a role for antioxidant/trace element intake in the modulation of ADMA, whose assessment may be a marker of metabolic syndrome manifestations. (c) 2009 Elsevier Inc. All rights reserved.
C1 [Puchau, Blanca; Zulet, Maria A.; Urtiaga, Goizane; Alfredo Martinez, J.] Univ Navarra, Dept Nutr & Food Sci Physiol & Toxicol, Pamplona 31008, Spain.
   [Navarro-Blasco, Inigo] Univ Navarra, Dept Chem & Soil Sci, Pamplona 31008, Spain.
C3 University of Navarra; University of Navarra
RP Martínez, JA (corresponding author), Univ Navarra, Dept Nutr & Food Sci Physiol & Toxicol, Pamplona 31008, Spain.
EM jalfmtz@unav.es
RI Zulet, M. Angeles/H-1317-2017; Martinez Hernandez, J
   Alfredo/K-8709-2014; Navarro-Blasco, Inigo/D-8148-2012
OI Zulet, M. Angeles/0000-0002-3926-0892; Martinez Hernandez, J
   Alfredo/0000-0001-5218-6941; Navarro-Blasco, Inigo/0000-0003-1863-0580
FU Linea Especial about Nutrition, Obesity, and Health [LE/97]; Health
   Department of the Government of Navarra [22/2007]; Ibercaja; Asociacion
   de Amigos fellowships scheme (BP) of the University of Navarra
FX This Study is supported by the Linea Especial about Nutrition, Obesity,
   and Health (LE/97); the Health Department of the Government of Navarra
   (22/2007); Ibercaja; and the Asociacion de Amigos fellowships scheme
   (BP) of the University of Navarra. We thank Amaia Gonzalez de Echdvarri
   for her help with the recruitment and the data collection, Veronica
   Ciaiurriz and Ana Lorente for technical assistance, Blanca Martinez de
   Morentin and Salome Perez for assistance with the data collection, and
   all those who volunteered to participate in the Study. The authors
   declare no conflict of interest in relation to this Study.
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NR 50
TC 19
Z9 20
U1 0
U2 1
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0026-0495
EI 1532-8600
J9 METABOLISM
JI Metab.-Clin. Exp.
PD OCT
PY 2009
VL 58
IS 10
BP 1483
EP 1488
DI 10.1016/j.metabol.2009.04.037
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 500TF
UT WOS:000270327100018
PM 19586644
DA 2025-06-11
ER

PT J
AU Younis, A
   Goldkorn, R
   Goldenberg, I
   Geva, D
   Tzur, B
   Mazu, A
   Younis, A
   Fisman, Z
   Tannenbaum, A
   Klempfner, R
AF Younis, Arwa
   Goldkorn, Ronen
   Goldenberg, Ilan
   Geva, Diklah
   Tzur, Boaz
   Mazu, Anna
   Younis, Anan
   Fisman, Zvi
   Tannenbaum, Alexander
   Klempfner, Robert
TI Impaired Fasting Glucose Is the Major Determinant of the 20-Year
   Mortality Risk Associated With Metabolic Syndrome in Nondiabetic
   Patients With Stable Coronary Artery Disease
SO JOURNAL OF THE AMERICAN HEART ASSOCIATION
LA English
DT Article
DE impaired glucose tolerance; metabolic syndrome; mortality
ID ACUTE MYOCARDIAL-INFARCTION; ELUTING STENT IMPLANTATION;
   CARDIOVASCULAR-DISEASE; STRESS HYPERGLYCEMIA; INSULIN-RESISTANCE;
   REDUCING TRIGLYCERIDES; SECONDARY PREVENTION; HEART-DISEASE; ALL-CAUSE;
   IMPACT
AB Background-We wanted to explore the association of metabolic syndrome (MetS) versus its individual components with 20-year all-cause mortality among patients with stable coronary artery disease.
   Methods and Results-The cohort comprised 12 403 nondiabetic patients with stable coronary artery disease who were enrolled in the Bezafibrate Infarction Prevention Registry between February 1990 and October 1992 and followed up through December 2014. The study cohort was divided into 4 groups: patients without MetS or impaired fasting glucose (IFG), patients with IFG but without MetS, patients with MetS but without IFG, and patients with both MetS and IFG. Kaplan-Meier survival analysis showed that at 20 years of follow-up, the rates of all-cause mortality were the highest among patients with both MetS and IFG (66%). Patients with IFG without MetS experienced a significantly higher mortality rate compared with those with MetS without IFG (61% versus 56%; log-rank P<0.001). Multivariable Cox proportional hazard analysis showed that the final Cox model demonstrated that the additive effect of MetS (hazard ratio, 1.13; 95% confidence interval, 1.1-1.16; P=0.02) and IFG (hazard ratio, 1.54; 95% confidence interval, 1.46-1.62; P<0.001) on 20 years mortality was nonsignificant (hazard ratio, 1.01; 95% confidence interval, 0.93-1.11; P=0.69). IFG was associated with the most pronounced increase in mortality risk among the individual components (hazard ratio, 1.22; 95% confidence interval, 1.14-1.3; P<0.001).
   Conclusions-Our findings suggest that IFG alone is a major independent predictor of long-term mortality among patients with stable coronary artery disease versus other components of the MetS.
C1 [Younis, Arwa; Goldkorn, Ronen; Goldenberg, Ilan; Geva, Diklah; Tzur, Boaz; Mazu, Anna; Younis, Anan; Tannenbaum, Alexander; Klempfner, Robert] Sheba Med Ctr, Leviev Heart Ctr, Ramat Gan, Israel.
   [Younis, Arwa; Goldkorn, Ronen; Goldenberg, Ilan; Geva, Diklah; Tzur, Boaz; Fisman, Zvi; Tannenbaum, Alexander; Klempfner, Robert] Tel Aviv Univ, Sakler Sch Med, Tel Aviv, Israel.
C3 Chaim Sheba Medical Center; Tel Aviv University; Tel Aviv University
RP Younis, A (corresponding author), Sheba Med Ctr, Heart Ctr, Sheba Rd 2, IL-52620 Ramat Gan, Israel.
EM or.younis@gmail.com
RI Klempfner, Robert/M-4989-2016
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NR 50
TC 11
Z9 12
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
EI 2047-9980
J9 J AM HEART ASSOC
JI J. Am. Heart Assoc.
PD NOV
PY 2017
VL 6
IS 11
AR e006609
DI 10.1161/JAHA.117.006609
PG 11
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA FR3CO
UT WOS:000418943800027
PM 29079562
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Garber, AJ
AF Garber, A. J.
TI Obesity and type 2 diabetes: which patients are at risk?
SO DIABETES OBESITY & METABOLISM
LA English
DT Review
DE diabetes complications; glucose metabolism; insulin resistance;
   treatment guidelines; type 2 diabetes; weight-loss therapy
ID IMPAIRED GLUCOSE-TOLERANCE; FASTING GLUCOSE; CARDIOVASCULAR-DISEASE;
   INSULIN-RESISTANCE; ADIPOSE-TISSUE; ECTOPIC FAT; WEIGHT-LOSS; PREVENTION
   PROGRAM; METABOLIC SYNDROME; RECEPTOR AGONISTS
AB An estimated 72.5 million American adults are obese, and the growing US obesity epidemic is responsible for substantial increase in morbidity and mortality, as well as increased health care costs. Obesity results from a combination of personal and societal factors, but is often viewed as a character flaw rather than a medical condition. This leads to stigma and discrimination towards obese individuals and decreases the likelihood of effective intervention. Conditions related to obesity are increasingly common, such as metabolic syndrome, impaired fasting glucose (IFG) and impaired glucose tolerance (IGT), all of which indicate high risk for type 2 diabetes (T2DM). This paper reviews the progression from obesity to diabetes, identifying physiological changes that occur along this path as well as opportunities for patient identification and disease prevention. Patients with prediabetes (defined as having IFG, IGT or both) and/or metabolic syndrome require interventions designed to preserve insulin sensitivity and beta-cell function, both of which start to deteriorate prior to T2DM diagnosis. Lifestyle modification, including both healthy eating choices and increased physical activity, is essential for weight management and diabetes prevention. Although sustained weight loss is often considered by patients and physicians as being impossible to achieve, effective interventions do exist. Specifically, the Diabetes Prevention Program (DPP) and programs modelled along its parameters have shown repeated successes, even with long-term maintenance. Recent setbacks in the development of medications for weight loss further stress the importance of lifestyle management. By viewing obesity as a metabolic disorder rather than a personal weakness, we can work with patients to address this increasingly prevalent condition and improve long-term health outcomes.
C1 [Garber, A. J.] Baylor Coll Med, Dept Med, Houston, TX 77030 USA.
   [Garber, A. J.] Baylor Coll Med, Dept Biochem & Mol Biol, Houston, TX 77030 USA.
   [Garber, A. J.] Baylor Coll Med, Dept Mol & Cellular Biol, Houston, TX 77030 USA.
C3 Baylor College of Medicine; Baylor College of Medicine; Baylor College
   of Medicine
RP Garber, AJ (corresponding author), Baylor Coll Med, Dept Med, Houston, TX 77030 USA.
EM agarber@bcm.tmc.edu
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NR 105
TC 72
Z9 87
U1 2
U2 29
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1462-8902
EI 1463-1326
J9 DIABETES OBES METAB
JI Diabetes Obes. Metab.
PD MAY
PY 2012
VL 14
IS 5
BP 399
EP 408
DI 10.1111/j.1463-1326.2011.01536.x
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 918GQ
UT WOS:000302237700002
PM 22074144
DA 2025-06-11
ER

PT J
AU Murray, R
   Correll, CU
   Reynolds, GP
   Taylor, D
AF Murray, Robin
   Correll, Christoph U.
   Reynolds, Gavin P.
   Taylor, David
TI Atypical antipsychotics: recent research findings and applications to
   clinical practice: Proceedings of a symposium presented at the 29th
   Annual European College of Neuropsychopharmacology Congress, 19
   September 2016, Vienna, Austria
SO THERAPEUTIC ADVANCES IN PSYCHOPHARMACOLOGY
LA English
DT Review
DE antipsychotic; cardiometabolic side effects; efficacy; nonresponse;
   schizophrenia; tolerability; treatment resistance
ID TREATMENT-RESISTANT SCHIZOPHRENIA; MULTIPLE-TREATMENTS METAANALYSIS;
   WEIGHT-GAIN; COMPARATIVE EFFICACY; INSULIN-RESISTANCE; DOUBLE-BLIND;
   1ST-EPISODE PSYCHOSIS; NETWORK METAANALYSIS; BIPOLAR DEPRESSION;
   CONTROLLED-TRIALS
AB Available evidence suggests that second-generation atypical antipsychotics are broadly similar to first-generation agents in terms of their efficacy, but may have a more favourable tolerability profile, primarily by being less likely to cause extrapyramidal symptoms. However, atypical antipsychotics are variably associated with disturbances in the cardiometabolic arena, including increased body weight and the development of metabolic syndrome, which may reflect differences in their receptor binding profiles. Effective management of schizophrenia must ensure that the physical health of patients is addressed together with their mental health. This should therefore involve consideration of the specific tolerability profiles of available agents and individualization of treatment to minimize the likelihood of adverse metabolic sequelae, thereby improving long-term adherence and optimizing overall treatment outcomes. Alongside this, modifiable risk factors (such as exercise, diet, obesity/body weight and smoking status) must be addressed, in order to optimize patients' overall health and quality of life (QoL). In addition to antipsychotic-induced side effects, the clinical management of early nonresponders and psychopharmacological approaches for patients with treatment-resistant schizophrenia remain important unmet needs. Evidence suggests that antipsychotic response starts early in the course of treatment and that early nonresponse accurately predicts nonresponse over the longer term. Early nonresponse therefore represents an important modifiable risk factor for poor efficacy and effectiveness outcomes, since switching or augmenting antipsychotic treatment in patients showing early nonresponse has been shown to improve the likelihood of subsequent treatment outcomes. Recent evidence has also demonstrated that patients showing early nonresponse to treatment with lurasidone at 2 weeks may benefit from an increase in dose at this timepoint without compromising tolerability/safety. However, further research is required to determine whether these findings are generalizable to other antipsychotic agents.
C1 [Murray, Robin] Kings Coll London, Inst Psychiat Psychol & Neurosci, 16 Crespigny Pk, London SE5 8AF, England.
   [Correll, Christoph U.] Zucker Hillside Hosp, Hofstra Northwell Sch Med, New York, NY USA.
   [Reynolds, Gavin P.] Sheffield Hallam Univ, Biomol Sci Res Ctr, Sheffield, S Yorkshire, England.
   [Taylor, David] Maudsley Hosp & Inst Psychiat, London, England.
C3 University of London; King's College London; Northwell Health; Sheffield
   Hallam University; University of London; King's College London; South
   London & Maudsley NHS Trust; Maudsley Hospital
RP Murray, R (corresponding author), Kings Coll London, Inst Psychiat Psychol & Neurosci, 16 Crespigny Pk, London SE5 8AF, England.
EM robin.murray@kcl.ac.uk
RI Reynolds, Gavin/AAM-9985-2020; Correll, Christoph/D-3530-2011
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NR 65
TC 26
Z9 26
U1 0
U2 12
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 2045-1253
J9 THER ADV PSYCHOPHARM
JI Ther. Adv. Psychopharm.
PD MAR
PY 2017
VL 7
IS 1
SU S
BP 1
EP 14
DI 10.1177/2045125317693200
PG 14
WC Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Psychiatry
GA EM6EY
UT WOS:000395406800001
PM 28344764
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Angel-Isaza, J
   Carmona-Hernandez, JC
   González-Correa, CH
   Narváez-Solarte, WV
AF Angel-Isaza, Jaime
   Carmona-Hernandez, Juan Carlos
   Gonzalez-Correa, Clara Helena
   Narvaez-Solarte, William Vicente
TI Potential Hypoglycemic and Antilipidemic Activity of Polyphenols from
   Passiflora ligularis (Granadilla)
SO MOLECULES
LA English
DT Article
DE Passiflora ligularis (granadilla); Camellia sinensis (green tea);
   glucose; lipids; murine model
ID GREEN TEA POLYPHENOL; FATTY LIVER-DISEASE; METABOLIC SYNDROME; OXIDATIVE
   STRESS; OBESITY; (-)-EPIGALLOCATECHIN-3-GALLATE; CATECHINS; SERUM
AB The consumption of fruits or by-products from plants of the Passifloraceae family has been associated with multiple health and nutritional benefits, due to their phenolic compound content. Likewise, the effects of polyphenols from Camellia sinensis (green tea) have been explored and are considered a reference for different biological actions of these bioactive substances. This study compared the hypoglycemic and antilipemic activity of polyphenol-rich extracts of Passiflora ligularis Juss (passion fruit) and Camellia sinensis (green tea) given to a group of Wistar rats induced to be overweight. The individuals were subjected to three doses of supplementation of both sources of polyphenols in the drinking water. An additional group without polyphenol supplementation served as a control group. Water consumption, weight gain, glycemia, cholesterol, serum triglycerides and percentage of fecal ethereal extracts were analyzed. Although Passiflora ligularis Juss had five times less polyphenol content than Camellia sinensis, rats fed doses of 2.5 and 3.0 g/L Passiflora ligularis Juss showed reduced glycemia by 16%, suggesting an antiglycemic activity similar to that of Camellia sinensis. On the other hand, higher doses of polyphenols from Passiflora ligularis Juss and Camellia sinensis significantly reduced triglyceride levels (p = 0.05) by more than 17% compared to the unsupplemented control group. The polyphenol-rich extracts produced effective inhibitory activity of lipemic metabolites with a reduction in the percentage of fecal lipids (p < 0.05), with no side effects on liver tissue. The 3.0 g/L dose produced the best result on signs of metabolic syndrome associated with excess weight. Polyphenols extracted from fresh Colombian passion fruit showed the potential to decrease metabolic syndrome risk factors in a murine model.
C1 [Angel-Isaza, Jaime; Gonzalez-Correa, Clara Helena; Narvaez-Solarte, William Vicente] Univ Caldas, Res Grp Nutr Metab & Food Secur NUTRIMESA, Manizales 170001, Colombia.
   [Carmona-Hernandez, Juan Carlos] Univ Manizales, Med Res Grp, Metab Nutr Polyphenols MeNutrO, Manizales 170004, Colombia.
C3 Universidad de Caldas; Universidad de Manizales
RP González-Correa, CH (corresponding author), Univ Caldas, Res Grp Nutr Metab & Food Secur NUTRIMESA, Manizales 170001, Colombia.
EM jaime.angel92@gmail.com; jucaca@umanizales.edu.co;
   clara.gonzalez@ucaldas.edu.co; wnarvaez@ucaldas.edu.co
RI Gonzalez-Correa, Clara/AAN-8895-2021; Carmona-Hernandez, Juan
   Carlos/O-9786-2014
OI Angel-Isaza, Jaime/0000-0003-1612-6938; Gonzalez-Correa, Clara
   Helena/0000-0001-5621-2166; Carmona-Hernandez, Juan
   Carlos/0000-0001-9944-4573
FU Universidad de Manizales (Colombia) [2014/II]; Colciencias (Bogota,
   Colombia) [647/2014]; Universidad de Caldas (Colombia)
FX This research was funded by Universidad de Manizales (Colombia) grant
   2014/II, Colciencias (Bogota, Colombia) grant 647/2014, and Universidad
   de Caldas (Colombia) with their consent to use all laboratory supplies
   and facilities.
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NR 47
TC 3
Z9 3
U1 3
U2 31
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1420-3049
J9 MOLECULES
JI Molecules
PD APR
PY 2023
VL 28
IS 8
AR 3551
DI 10.3390/molecules28083551
PG 11
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA E9KW9
UT WOS:000978655300001
PM 37110785
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Rinaldi, B
   Di Filippo, C
   Capuano, A
   Donniacuo, M
   Sodano, L
   Ferraraccio, F
   Rossi, F
   D'Amico, M
AF Rinaldi, B.
   Di Filippo, C.
   Capuano, A.
   Donniacuo, M.
   Sodano, L.
   Ferraraccio, F.
   Rossi, F.
   D'Amico, M.
TI Adiponectin elevation by telmisartan ameliorates ischaemic myocardium in
   zucker diabetic fatty rats with metabolic syndrome
SO DIABETES OBESITY & METABOLISM
LA English
DT Article
DE acute myocardial infarction; cardioprotection; metabolic syndrome;
   telmisartan; ZDF rats
ID PPAR-GAMMA AGONIST; C-REACTIVE PROTEIN; TOLL-LIKE RECEPTOR;
   CARDIOVASCULAR RISK; REPERFUSION INJURY; BLOOD-PRESSURE; ASSOCIATION;
   ADIPOSE; HYPOADIPONECTINEMIA; INFARCTION
AB Aim: This study investigated whether telmisartan, a selective angiotensin type 1 (AT1) receptor antagonist and gamma peroxisome proliferator-activated receptor (PPAR-gamma) partial agonist, reduces myocardial ischaemia/reperfusion (I/R) injury in an experimental model of metabolic syndrome.
   Methods: Zucker Diabetic Fatty (ZDF) rats were treated for 3 weeks with telmisartan at doses of 2, 7 and 12 mg/kg/day. After treatment, rats were subjected to a 25-min occlusion of the left descending coronary artery followed by 2-h reperfusion (I/R).
   Results: Telmisartan reduced the extension of the infarct size in a dose-dependent fashion and decreased the levels of plasma troponin I, a specific marker of myocardial damage. Telmisartan also caused a dose-dependent increase in adiponectin both in plasma and cardiac tissue of infarcted ZDF rats. These levels were minimally increased (p < 0.05 vs. vehicle) by telmisartan 7 mg/kg/day and reached the maximum values with the highest dose of 12 mg/kg/day (p < 0.01 vs. vehicle). In contrast, within the infarcted tissue telmisartan decreased the expression of markers of inflammation such as the transcription factor NF-kappa B, the toll-like receptors TLR2 and TLR4 as well as TNF-alpha cytokine. Nitrosative stress was maximal in vehicle-treated infarcted hearts as evidenced by increased expression of iNOS, which was almost abolished after treatement with telmisartan.
   Conclusions: Treatment of ZDF rats for 3 weeks with telmisartan, a dual angiotensin II receptor antagonist and partial PPAR-gamma receptor agonist, resulted in a significant reduction of myocardial damage induced by I/R and was assocciated with increased adiponectin and a decrease in inflammatory markers.
C1 [Rinaldi, B.; Di Filippo, C.; Capuano, A.; Donniacuo, M.; Sodano, L.; Rossi, F.; D'Amico, M.] Univ Naples 2, Dept Expt Med, Sect Pharmacol L Donatelli, I-80138 Naples, Italy.
   [Rinaldi, B.; Di Filippo, C.; Capuano, A.; Rossi, F.; D'Amico, M.] Univ Naples 2, Excellence Ctr Cardiovasc Dis, I-80138 Naples, Italy.
   [Ferraraccio, F.] Univ Naples 2, Dept Clin Publ & Prevent Med, I-80138 Naples, Italy.
C3 Universita della Campania Vanvitelli; Universita della Campania
   Vanvitelli; Universita della Campania Vanvitelli
RP Di Filippo, C (corresponding author), Univ Naples 2, Dept Expt Med, Sect Pharmacol L Donatelli, Via Costantinopoli 16, I-80138 Naples, Italy.
EM clara.difilippo@unina2.it
RI Donniacuo, Maria/AFM-9320-2022; D Amico, Michele/HSH-3483-2023
OI Donniacuo, Maria/0000-0001-7485-5755; d'amico,
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NR 58
TC 17
Z9 18
U1 0
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1462-8902
EI 1463-1326
J9 DIABETES OBES METAB
JI Diabetes Obes. Metab.
PD APR
PY 2012
VL 14
IS 4
BP 320
EP 328
DI 10.1111/j.1463-1326.2011.01527.x
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 903LD
UT WOS:000301117100005
PM 22050607
DA 2025-06-11
ER

PT J
AU Park, SK
   Auchincloss, AH
   O'Neill, MS
   Prineas, R
   Correa, JC
   Keeler, J
   Barr, RG
   Kaufman, JD
   Roux, AVD
AF Park, Sung Kyun
   Auchincloss, Amy H.
   O'Neill, Marie S.
   Prineas, Ronald
   Correa, Juan C.
   Keeler, Jerry
   Barr, R. Graham
   Kaufman, Joel D.
   Roux, Ana V. Diez
TI Particulate Air Pollution, Metabolic Syndrome, and Heart Rate
   Variability: The Multi-Ethnic Study of Atherosclerosis (MESA)
SO ENVIRONMENTAL HEALTH PERSPECTIVES
LA English
DT Article
DE air pollution; autonomic nervous system; heart rate variability;
   metabolic syndrome; PM2.5
ID EXPOSURE MEASUREMENT ERROR; AUTONOMIC DYSFUNCTION; OXIDATIVE STRESS;
   MORTALITY; OBESITY; EPIDEMIOLOGY; ASSOCIATION; PARTICLES; CRITERIA
AB BACKGROUND: Cardiac autonomic dysfunction has been suggested as a possible biologic pathway for the association between fine particulate matter <= 2.5 mu m in diameter (PM2.5) and cardiovascular disease (CVD). We examined the associations of PM2.5 with heart rate variability, a marker of autonomic function, and whether metabolic syndrome (MetS) modified these associations.
   METHODS: We used data from the Multi-Ethnic Study of Atherosclerosis to measure the standard deviation of normal-to-normal intervals (SDNN) and the root mean square of successive differences (rMSSD) of 5,465 participants 45-84 years old who were free of CVD at the baseline examination (2000-2002). Data from the U. S. regulatory monitor network were used to estimate ambient PM2.5 concentrations at the participants' residences. MetS was defined as having three or more of the following criteria: abdominal obesity, hypertriglyceridemia, low high-density lipoprotein cholesterol, high blood pressure, and high fasting glucose.
   RESULTS: After controlling for confounders, we found that an interquartile range (IQR) increase in 2-day average PM2.5 (10.2 mu g/m(3)) was associated with a 2.1% decrease in rMSSD [95% confidence interval (CI), -4.2 to 0.0] and nonsignificantly associated with a 1.8% decrease in SDNN (95% CI, -3.7 to 0.1). Associations were stronger among individuals with MetS than among those without MetS: an IQR elevation in 2-day PM2.5 was associated with a 6.2% decrease in rMSSD (95% CI, -9.4 to -2.9) among participants with MetS, whereas almost no change was found among participants without MetS (p-interaction = 0.005). Similar effect modification was observed in SDNN (p-interaction = 0.011).
   CONCLUSION: These findings suggest that autonomic dysfunction may be a mechanism through which PM exposure affects cardiovascular risk, especially among persons with MetS.
C1 [Park, Sung Kyun; O'Neill, Marie S.; Keeler, Jerry] Univ Michigan, Sch Publ Hlth, Dept Environm Hlth Sci, Ann Arbor, MI 48109 USA.
   [Auchincloss, Amy H.] Drexel Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Philadelphia, PA 19104 USA.
   [O'Neill, Marie S.; Roux, Ana V. Diez] Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA.
   [Prineas, Ronald] Wake Forest Univ, Bowman Gray Sch Med, Div Publ Hlth Sci, Winston Salem, NC USA.
   [Correa, Juan C.] Fdn Santa Fe Bogota, Bogota, Colombia.
   [Barr, R. Graham] Columbia Univ, Med Ctr, Dept Epidemiol, New York, NY USA.
   [Correa, Juan C.; Barr, R. Graham] Columbia Univ, Med Ctr, Dept Med, New York, NY USA.
   [Kaufman, Joel D.] Univ Washington, Sch Publ Hlth, Dept Environm & Occupat Hlth Sci, Seattle, WA 98195 USA.
C3 University of Michigan System; University of Michigan; Drexel
   University; University of Michigan System; University of Michigan; Wake
   Forest University; Wake Forest Baptist Medical Center; Columbia
   University; Columbia University; University of Washington; University of
   Washington Seattle
RP Park, SK (corresponding author), Univ Michigan, Sch Publ Hlth, Dept Environm Hlth Sci, SPH II M6240,1415 Washington Hts, Ann Arbor, MI 48109 USA.
EM sungkyun@umich.edu
RI ; Kaufman, Joel/B-5761-2008
OI Park, Sung Kyun/0000-0001-9981-6250; Kaufman, Joel/0000-0003-4174-9037
FU National Institute of Environmental Health Sciences [K01-ES016587-01A1];
   U.S. Environmental Protection Agency [R830543, RD831697]; National
   Heart, Lung, and Blood Institute [N01-HC-95159, N01-HC-95165,
   N01-HC-95169]
FX S.K.P. was supported by grant K01-ES016587-01A1 from the National
   Institute of Environmental Health Sciences. The study was supported by
   grants R830543 and RD831697 from the U.S. Environmental Protection
   Agency. The Multi-Ethnic Study of Atherosclerosis (MESA) is supported by
   contracts N01-HC-95159 through N01-HC-95165 and N01-HC-95169 from the
   National Heart, Lung, and Blood Institute (contracts N01-HC-95159
   through N01-HC-95165 and N01-HC-95169).
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NR 36
TC 100
Z9 120
U1 0
U2 43
PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE
PI RES TRIANGLE PK
PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233,
   RES TRIANGLE PK, NC 27709-2233 USA
SN 0091-6765
EI 1552-9924
J9 ENVIRON HEALTH PERSP
JI Environ. Health Perspect.
PD OCT
PY 2010
VL 118
IS 10
BP 1406
EP 1411
DI 10.1289/ehp.0901778
PG 6
WC Environmental Sciences; Public, Environmental & Occupational Health;
   Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health; Toxicology
GA 656YL
UT WOS:000282376900032
PM 20529761
OA Green Submitted, gold, Green Published
DA 2025-06-11
ER

PT J
AU Mogi, M
   Tsukuda, K
   Li, JM
   Wanarni, J
   Min, LJ
   Sakata, A
   Fujita, T
   Iwai, M
   Horiuchi, M
AF Mogi, Masaki
   Tsukuda, Kana
   Li, Jian-Mei
   Wanarni, Jun
   Min, Li-Juan
   Sakata, Akiko
   Fujita, Teppei
   Iwai, Masaru
   Horiuchi, Masatsugu
TI Inhibition of cognitive decline in mice fed a high-salt and cholesterol
   diet by the angiotensin receptor blocker, olmesartan
SO NEUROPHARMACOLOGY
LA English
DT Article
DE angiotensin II receptors; high-salt diet; high-cholesterol diet;
   cognitive impairment
ID SUPEROXIDE ANION PRODUCTION; BLOOD-PRESSURE; OXIDATIVE STRESS; II
   TYPE-1; METABOLIC SYNDROME; RANDOMIZED-TRIAL; DIABETIC MICE; ELDERLY
   SCOPE; OLDER WOMEN; DAHL RATS
AB The metabolic syndrome is closely related to dietary habits and seems to be associated with impairment of cognitive function in humans. Angiotensin receptor blockers are widely used with the expectation of preventing cardiovascular events and stroke and potential amelioration of the metabolic syndrome. We examined the diet-induced changes of cognitive function in mice treated with a high-salt and high-cholesterol diet. C57BL/6J mice were fed a high-salt (2% NaCl in drinking water) and high-cholesterol (1.25% cholesterol, 10% coconut oil) diet (HSCD) or a normal diet (ND), and subjected to 20 trials of a passive avoidance task every week from 8 weeks of age. An age-dependent decline of the avoidance rate starting from 10 weeks of age was observed in HSCD mice, whereas the avoidance rate gradually increased in the ND group. Oral administration of an angiotensin receptor blocker, olmesartan, at a dose of 3 mg/kg per day in drinking water from 8 weeks of age prevents this decline of avoidance rate in HSCD mice (49% vs. 82% at 12 weeks of age). Treatment with olmesartan significantly decreased serum glucose and cholesterol levels in HSCD mice, with a slight decrease in blood pressure. Administration of olmesartan in HSCD-fed mice showed a 1.6-fold increase in mRNA expression of a neuroprotective factor, MMS2, compared to HSCD-fed mice without olmesartan. Olmesartan attenuated the increase in superoxide anion production detected by dihydroethidium staining in the brain of HSCD mice. Our results suggest that olmesartan could be therapeutically effective in preventing the impairment of quality of life in persons on a high-fat and high-salt diet. (c) 2007 Elsevier Ltd. All rights reserved.
C1 [Mogi, Masaki; Tsukuda, Kana; Li, Jian-Mei; Wanarni, Jun; Min, Li-Juan; Sakata, Akiko; Fujita, Teppei; Iwai, Masaru; Horiuchi, Masatsugu] Ehime Univ, Grad Sch Med, Dept Mol Cardiovasc Biol & Pharmacol, Matsuyama, Ehime 7910295, Japan.
C3 Ehime University
RP Horiuchi, M (corresponding author), Ehime Univ, Grad Sch Med, Dept Mol Cardiovasc Biol & Pharmacol, Matsuyama, Ehime 7910295, Japan.
EM horiuchi@m.ehime-u.ac.jp
RI Mogi, Masaki/ABH-2011-2020
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NR 44
TC 33
Z9 38
U1 1
U2 4
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0028-3908
EI 1873-7064
J9 NEUROPHARMACOLOGY
JI Neuropharmacology
PD DEC
PY 2007
VL 53
IS 8
BP 899
EP 905
DI 10.1016/j.neuropharm.2007.08.020
PG 7
WC Neurosciences; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pharmacology & Pharmacy
GA 245UT
UT WOS:000251965000002
PM 18028965
DA 2025-06-11
ER

PT J
AU On, S
   Na, W
   Sohn, C
AF On, Sori
   Na, Woori
   Sohn, Cheongmin
TI The mediating effect of the Korean Healthy Eating Index on the
   relationship between lifestyle patterns and metabolic syndrome in
   middle-aged Koreans: data from the 2019-2021 Korea National Health and
   Nutrition Examination Survey
SO NUTRITION RESEARCH AND PRACTICE
LA English
DT Article
DE Metabolic syndrome; mediation analysis; nutrition assessment, life
   style; middle aged
ID RISK
AB BACKGROUND/OBJECTIVES: Metabolic syndrome (MetS) is closely connected to dietary and lifestyle factors, with diet being one of the primary risk factors for MetS, acting as a key factor in both prevention and management. In this study, we analyzed the mediating effect of the Korean Healthy Eating Index (KHEI) on the relationship between lifestyle patterns and MetS in middle-aged Koreans using data from the 2019-2021 Korea National Health and Nutrition Examination Survey (KNHANES). SUBJECTS/METHODS: This study examined data from 5,196 adults aged 40-64 yrs who participated in the eighth KNHANES. Data on 5 lifestyle factors-smoking, alcohol consumption, physical activity, sleep duration, and stress perception-were analyzed. The latent class analysis (LCA) was performed using Mplus 8.11, and SPSS PROCESS Macro v4.2 was used for statistical analysis to analyze the mediating effect of the KHEI. RESULTS: The model categorized lifestyle factors into three into 3 clusters: 'Low Activity Class,' 'Low Activity and Smoking Class,' and 'Multiple Risk Class.' The KHEI mediation analysis showed significant effects: 0.0205 (95% confidence interval [CI], 0.0062-0.0363) in the 'Low Activity and Smoke Class,' and 0.0420 (95% CI, 0.0133-0.0726) in the 'Multiple Risk Class.' The mediating effect of the KHEI domain "adequacy" was significant in these groups, with effects of 0.0357 (95% CI, 0.0184-00563) and 0.0662 (95% CI, 0.0364-0.6491), for the respective groups. Balance of energy intake was significant in the group with 'Multiple Risk Class' (0.0189; 95% CI, 0.0044-0.0378). CONCLUSION: The results suggest that a healthy diet improves health management and reduces risk factors for MetS. Nonetheless, better strategies for dietary improvement through a detailed analysis of KHEI components are warranted.
C1 [On, Sori; Na, Woori; Sohn, Cheongmin] Wonkwang Univ, Dept Food & Nutr, 460 Iksan Daero, Iksan 54538, South Korea.
   [Na, Woori; Sohn, Cheongmin] Wonkwang Univ, Inst Life Sci & Nat Resources, 460 Iksan Daero, Iksan 54538, South Korea.
C3 Wonkwang University; Wonkwang University
RP Sohn, C (corresponding author), Wonkwang Univ, Dept Food & Nutr, 460 Iksan Daero, Iksan 54538, South Korea.; Sohn, C (corresponding author), Wonkwang Univ, Inst Life Sci & Nat Resources, 460 Iksan Daero, Iksan 54538, South Korea.
EM ccha@wku.ac.kr
CR Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
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NR 30
TC 0
Z9 0
U1 0
U2 0
PU KOREAN NUTRITION SOC
PI SEOUL
PA 804 KST CTR, 635-4 YEOGSAM-SONG KANGNAM-KU, SEOUL, 135-703, SOUTH KOREA
SN 1976-1457
EI 2005-6168
J9 NUTR RES PRACT
JI Nutr. Res. Pract.
PD FEB
PY 2025
VL 19
IS 1
BP 96
EP 106
DI 10.4162/nrp.2025.19.1.96
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA X1F1H
UT WOS:001422883200008
PM 39959746
OA gold
DA 2025-06-11
ER

PT J
AU Wang, JY
   Bai, Y
   Zeng, ZH
   Wang, J
   Wang, P
   Zhao, YG
   Xu, WL
   Zhu, Y
   Qi, XY
AF Wang, Jingya
   Bai, Yang
   Zeng, Zihang
   Wang, Jun
   Wang, Ping
   Zhao, Yongai
   Xu, Weili
   Zhu, Yun
   Qi, Xiuying
TI Association between life-course cigarette smoking and metabolic
   syndrome: a discovery-replication strategy
SO DIABETOLOGY & METABOLIC SYNDROME
LA English
DT Article
DE Cigarette smoking; Metabolic syndrome; Discovery-replication strategy;
   Interaction; Cross-sectional study
ID CARDIOVASCULAR-DISEASE; NATIONAL-HEALTH; CHINA HEALTH; RISK-FACTOR;
   BODY-FAT; MORTALITY; OBESITY; HISTORY; STRESS
AB Background The relation between cigarette smoking and metabolic syndrome (MetS) remains unclear, and previous studies focusing on MetS are limited in sample size. We investigated the association between life-course smoking and MetS with independent discovery and replication samples. Methods Preliminary analysis utilized data from an annual cross-sectional survey of 15,222 participants aged >= 60 years in Tianjin, China. Suggestive associations were followed-up in 8565 adults from the China Health and Nutrition Survey. MetS was identified according to the criteria of the Chinese Diabetes Society in 2013. Life-course smoking was assessed by a comprehensive smoking index (CSI), based on information on smoking intensity, duration, and time since cessation across life-course, collected through standard questionnaires. Participants were divided into four groups: non-smokers; and the tertiles of CSI in ever smokers. Multivariable logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for the association between life-course smoking and MetS. Results In the discovery sample, ORs of MetS were 2.01 (95%CI: 1.64-2.47) and 1.76 (95%CI: 1.44-2.16) for smokers in the highest and second tertile of CSI compared with never smokers. Potential interaction was shown for age, with increased ORs for MetS associated with smoking limited to individuals who aged < 70 years (P-interaction = 0.015). We were able to replicate the association between cigarette smoking and MetS in an independent adult sample (second tertile vs. never: OR = 1.30, 95%CI: 1.04-1.63). The interaction of smoking with age was also replicated. Conclusions Life-course cigarette smoking is associated with an increased odds of MetS, especially among individuals who aged < 70 years.
C1 [Wang, Jingya; Bai, Yang; Zeng, Zihang; Xu, Weili; Zhu, Yun; Qi, Xiuying] Tianjin Med Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Qixiangtai Rd 22, Tianjin 300070, Peoples R China.
   [Wang, Jingya; Bai, Yang; Zeng, Zihang; Xu, Weili; Zhu, Yun; Qi, Xiuying] Tianjin Key Lab Environm Nutr & Publ Hlth, Tianjin, Peoples R China.
   [Wang, Jun; Wang, Ping; Zhao, Yongai] Tianjin Santan Hosp, Tianjin, Peoples R China.
   [Xu, Weili] Karolinska Inst, Aging Res Ctr, Dept Neurobiol Care Sci & Soc, Stockholm, Sweden.
C3 Tianjin Medical University; Karolinska Institutet
RP Zhu, Y; Qi, XY (corresponding author), Tianjin Med Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Qixiangtai Rd 22, Tianjin 300070, Peoples R China.; Zhu, Y; Qi, XY (corresponding author), Tianjin Key Lab Environm Nutr & Publ Hlth, Tianjin, Peoples R China.
EM yun.zhu@tmu.edu.cn; qixiuying@tmu.edu.cn
RI Xu, Weili/AAB-6530-2020; Bai, Yang/MNO-4555-2025; Zhang,
   Zihe/KDN-3311-2024
FU National Natural Science Foundation of China [81771519]
FX This study was supported by the grant from the National Natural Science
   Foundation of China (No. 81771519).
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NR 40
TC 21
Z9 22
U1 1
U2 2
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1758-5996
J9 DIABETOL METAB SYNDR
JI Diabetol. Metab. Syndr.
PD JAN 15
PY 2022
VL 14
IS 1
AR 11
DI 10.1186/s13098-022-00784-2
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA YH1DE
UT WOS:000742914400003
PM 35033177
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Botha, J
   Nielsen, MH
   Christensen, MH
   Vestergaard, H
   Handberg, A
AF Botha, Jaco
   Nielsen, Morten Hjuler
   Christensen, Maja Hoegh
   Vestergaard, Henrik
   Handberg, Aase
TI Bariatric surgery reduces CD36-bearing microvesicles of endothelial and
   monocyte origin
SO NUTRITION & METABOLISM
LA English
DT Article
DE Extracellular vesicles; CD36; Obesity; Ectopic fat deposition; Metabolic
   syndrome; Bariatric surgery
ID SCAVENGER RECEPTOR CD36; ACID TRANSPORTER CD36; FATTY LIVER-DISEASE;
   CIRCULATING MICROPARTICLES; EXTRACELLULAR VESICLES; METABOLIC SYNDROME;
   EXPRESSION; OBESITY; INTERVENTION; MACROPHAGES
AB BackgroundBariatric surgery is a widely adopted treatment for obesity and its secondary complications. In the past decade, microvesicles (MVs) and CD36 have increasingly been considered as possible biomarkers for obesity, the metabolic syndrome (MetSy), type 2 diabetes mellitus (T2DM). Thus, the purpose of this study was to investigate how weight loss resulting from bariatric surgery affects levels of specific MV phenotypes and their expression of CD36 scavenger receptor. Additionally, we hypothesised that subjects with MetSy had higher baseline concentrations of investigated MV phenotypes.MethodsTwenty individuals undergoing Roux-en-Y gastric bypass surgery were evaluated before and 3months after surgery. MVs were characterised by flow cytometry at both time points and defined as lactadherin-binding particles within a 100-1000nm size gate. MVs of monocyte (CD14) and endothelial (CD62E) origin were defined by cell-specific markers, and their expression of CD36 was investigated.ResultsFollowing bariatric surgery, subjects incurred an average BMI reduction (delta) of -8.41.4 (p<0.0001). Significant reductions were observed for the total MVs (-66.55%, p=0.0017) and MVs of monocyte (-36.11%, p=0.0056) and endothelial (-40.10%, p=0.0007) origins. Although the bulk of CD36-bearing MVs were unaltered, significant reductions were observed for CD36-bearing MVs of monocyte (-60.04%, p=0.0192) and endothelial (-54.93%, p=0.04) origin. No differences in levels of MVs were identified between subjects who presented with MetSy at baseline (n=13) and those that did not (n=7).Conclusion p id=Par4 Bariatric surgery resulted in significantly altered levels of CD36-bearing MVs of monocyte and endothelial origin. This likely reflects improvements in ectopic fat distribution, plasma lipid profile, low-grade inflammation, and oxidative stress following weight loss. Conversely, however, the presence of MetSy at baseline had no impact on MV phenotypes.
C1 [Botha, Jaco; Nielsen, Morten Hjuler; Christensen, Maja Hoegh; Handberg, Aase] Aalborg Univ Hosp, Dept Clin Biochem, Hobrovej 18-22, DK-9000 Aalborg, Denmark.
   [Botha, Jaco; Handberg, Aase] Aalborg Univ, Dept Clin Med, Fac Med, Sdr Skowej 15, DK-9000 Aalborg, Denmark.
   [Vestergaard, Henrik] Univ Copenhagen, Sect Metab Genet, Novo Nordisk Fdn Ctr Basic Metab Res, SUND, Bygning 7,8 Etage, DK-2200 Copenhagen N, Denmark.
C3 Aalborg University; Aalborg University Hospital; Aalborg University;
   Novo Nordisk Foundation; University of Copenhagen
RP Botha, J (corresponding author), Aalborg Univ Hosp, Dept Clin Biochem, Hobrovej 18-22, DK-9000 Aalborg, Denmark.; Botha, J (corresponding author), Aalborg Univ, Dept Clin Med, Fac Med, Sdr Skowej 15, DK-9000 Aalborg, Denmark.
EM j.botha@rn.dk
RI Botha, Jaco/HDO-5386-2022; Handberg, Aase/G-6744-2011
OI Nielsen, Morten Hjuler/0000-0003-0748-6296; Handberg,
   Aase/0000-0001-5719-203X; Vestergaard, Henrik/0000-0003-3090-269X;
   Botha, Jaco/0000-0002-8889-9959
FU Novo Nordisk Foundation [NNF13OC0007713]
FX The study was supported by a grant from The Novo Nordisk Foundation
   (NNF13OC0007713). None of the funding bodies had any role in the design
   or conduct of this study nor in the preparation of this manuscript.
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NR 56
TC 9
Z9 9
U1 0
U2 3
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1743-7075
J9 NUTR METAB
JI Nutr. Metab.
PD OCT 23
PY 2018
VL 15
AR 76
DI 10.1186/s12986-018-0309-4
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA GY0MS
UT WOS:000448215500001
PM 30386406
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Barreto, FM
   Simao, ANC
   Morimoto, HK
   Lozovoy, MAB
   Dichi, I
   Miglioranza, LHD
AF Barreto, Fablola Malaga
   Colado Simao, Andrea Name
   Morimoto, Helena Kaminami
   Batisti Lozovoy, Marcell Alysson
   Dichi, Isaias
   da Silva Miglioranza, Lucia Helena
TI Beneficial effects of Lactobacillus plantarum on glycemia and
   homocysteine levels in postmenopausal women with metabolic syndrome
SO NUTRITION
LA English
DT Article
DE Metabolic syndrome; Probiotics; Lactobacillus plantarum; Homocysteine;
   Cytokines
ID GAMMA-GLUTAMYL-TRANSFERASE; OXIDATIVE STRESS; INSULIN-RESISTANCE;
   GASSERI SBT2055; LIVER-ENZYMES; PROBIOTICS; DISEASE; OBESITY; ACID
AB Objective: Metabolic syndrome (MetS) in postmenopausal women is an important risk factor for cardiovascular morbidity, especially stroke and coronary heart disease and mortality. Preventing and treating MetS would be useful in preventing disability and promoting normal aging. Previous human studies have found some beneficial effects of Lactobacillus species on some isolated parameters of MetS. Nevertheless, we are not aware, to date, of any study which has verified the influence of probiotics in patients with MetS. Therefore, the aim of the present study was to evaluate the influence of fermented milk with L. plantarum in the classical parameters related to MetS, as well as in other parameters related to cardiovascular risk in postmenopausal women.
   Methods: Twenty-four individuals were paired by age, ethnicity, and body mass index in two groups: Non-fermented milk (NFM = 12) 80 mL/d and fermented milk (FM = 12) 80 mL/d. Anthropometric and blood pressure measurements, biochemical, inflammatory, and immunologic biomarkers were measured.
   Results: Total cholesterol and gamma-glutamyltranspeptidase had a significant reduction both in NFM (P = 0.043 and P = 0.036, respectively) and FM groups (P = 0.010 and P = 0.018, respectively) after 90 d, whereas low-density lipoprotein cholesterol showed a significant reduction in NFM group (P = 0.002) and trend in the FM group (P = 0.092). Glucose and homocysteine levels showed a significant reduction in the FM group compared with the NFM group (P = 0.037 and P = 0.019, respectively). In relation to inflammatory biomarkers, there was a significant decrease in interleukin-6 both in NFM (P = 0.032) and in FM (P = 0.001) groups.
   Conclusion: FM with L. plantarum showed more favorable results than NFM in relation to cardiovascular risk factors in postmenopausal women with MetS. (C) 2014 Elsevier Inc. All rights reserved.
C1 [Barreto, Fablola Malaga; da Silva Miglioranza, Lucia Helena] Univ Londrina, Dept Food Sci & Technol, Londrina, Parana, Brazil.
   [Colado Simao, Andrea Name; Morimoto, Helena Kaminami; Batisti Lozovoy, Marcell Alysson] Univ Londrina, Dept Pathol Clin Anal & Toxicol, Londrina, Parana, Brazil.
   [Dichi, Isaias] Univ Londrina, Dept Internal Med, Londrina, Parana, Brazil.
RP Dichi, I (corresponding author), Univ Londrina, Dept Internal Med, Londrina, Parana, Brazil.
EM Dichi@sercomtel.com.br
RI Lozovoy, Marcell/AAM-4897-2021; Simão, Andrea/AAM-4892-2021;
   Miglioranza, Lucia/H-1656-2012
CR Andreasen AS, 2010, BRIT J NUTR, V104, P1831, DOI 10.1017/S0007114510002874
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NR 28
TC 102
Z9 105
U1 3
U2 29
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0899-9007
EI 1873-1244
J9 NUTRITION
JI Nutrition
PD JUL-AUG
PY 2014
VL 30
IS 7-8
BP 939
EP 942
DI 10.1016/j.nut.2013.12.004
PG 4
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA AL7IB
UT WOS:000339306300031
PM 24613434
DA 2025-06-11
ER

PT J
AU Jha, SS
   Kumar, M
   Agrawal, PK
   Thakur, DK
AF Jha, S. S.
   Kumar, Mahendra
   Agrawal, Pawan Kumar
   Thakur, Deepak Kumar
TI Osteoporosis in Asthma and COPD
SO INDIAN JOURNAL OF ORTHOPAEDICS
LA English
DT Review
DE Asthma; COPD; Asthma-Chronic Obstructive Pulmonary Disease Overlap
   Syndrome (ACOS)
ID OBSTRUCTIVE PULMONARY-DISEASE; VERTEBRAL FRACTURES; BONE-RESORPTION;
   EXACERBATIONS; INFLAMMATION; OSTEOBLASTS; PREVALENCE; PREDICTORS; BURDEN
AB Asthma and Chronic Obstructive Pulmonary Disease (COPD) are principally lifestyle related chronic inflammatory airway disease. They are globally associated with various systemic comorbidities and mortality. Osteoporosis is the common associated metabolic bone disease with respiratory disturbances, which affect the prognosis and increase mortality and morbidity in the patients. Apart from OSTEOPOROSIS, exhaustive attention has been paid towards other associated systemic comorbidities like cardiovascular diseases, cerebrovascular diseases, metabolic syndrome, malnutrition, skeletal muscle dysfunction (sarcopenia), anxiety, depression and so on (Iheanacho et al. in Int J Chronic Obstr Pulm Dis 15:439-460, 2020; Singh et al. in Eur Respir J 53:1900164, 2019). Osteoporosis is a significant extrapulmonary manifestation in asthma and COPD, which are grossly neglected and inadequately treated. The comorbidities have significant impact in terms of morbidity, mortality and economic burden in asthma and COPD patients, hence management of asthma and COPD should comprise thorough management, as this will also have an impact on the outcome of these patients. Various risk factors such as smoking, systemic inflammation, vitamin deficiency, and the use of oral or inhaled corticosteroid are responsible for osteoporosis in patients with asthma and COPD. The presence of osteoporosis in patients with asthma and COPD is invariably asymptomatic unless complicated by fragility fractures, therefore, it is necessary to explore the pathogenesis of osteoporosis in asthma and COPD and special attention is to be paid for early recognition of patients at high risk for osteoporosis in these patients. This chapter is focussed on osteoporosis as an extrapulmonary manifestation of asthma and COPD with an emphasis on the pathogenesis, risk factor, potential mechanism of osteoporosis, diagnosis, and prevention with passing reference to treatment as well in asthma and COPD patients.
C1 [Jha, S. S.] Nalanda Med Coll, Dept Orthopaed, Patna, India.
   [Jha, S. S.] Harishchandra Inst Orthopaed & Res, Patna, India.
   [Jha, S. S.] IOA Orthopaed Rheumatol Subcomm, New Delhi, India.
   [Jha, S. S.] IOA Osteoporosis Subcomm, New Delhi, India.
   [Jha, S. S.] Innovat Educ & Sci Res Fdn, New Delhi, India.
   [Kumar, Mahendra; Agrawal, Pawan Kumar; Thakur, Deepak Kumar] Patna Med Coll, Dept Pulm Med, Patna, India.
RP Jha, SS (corresponding author), Harishchandra Inst Orthopaed & Res, Patna, India.; Jha, SS (corresponding author), IOA Orthopaed Rheumatol Subcomm, New Delhi, India.; Jha, SS (corresponding author), IOA Osteoporosis Subcomm, New Delhi, India.; Jha, SS (corresponding author), Innovat Educ & Sci Res Fdn, New Delhi, India.
EM drssjha@gmail.com
RI Jha, S. S./JQV-3316-2023
OI Jha, S. S./0000-0002-3113-9465
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NR 34
TC 3
Z9 3
U1 4
U2 11
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0019-5413
EI 1998-3727
J9 INDIAN J ORTHOP
JI Indian J. Orthop.
PD DEC
PY 2023
VL 57
IS SUPPL 1
SU 1
SI SI
BP 200
EP 208
DI 10.1007/s43465-023-01048-5
EA NOV 2023
PG 9
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA HY4A3
UT WOS:001111062800001
PM 38107800
OA Green Published
DA 2025-06-11
ER

PT J
AU Kaps, L
   Labenz, C
   Galle, PR
   Weinmann-Menke, J
   Kostev, K
   Schattenberg, JM
AF Kaps, Leonard
   Labenz, Christian
   Galle, Peter R.
   Weinmann-Menke, Julia
   Kostev, Karel
   Schattenberg, Joern M.
TI Non-alcoholic fatty liver disease increases the risk of incident chronic
   kidney disease
SO UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
LA English
DT Article
DE NASH; NAFLD; metabolic syndrome; anxiety disorder; depression; metabolic
   inflammation
ID FIBROSIS STAGE; MORTALITY; NAFLD
AB Background and aim Non-alcoholic fatty liver disease (NAFLD) is a highly prevalent chronic liver disease. Its role in the development of extrahepatic co-morbidities is under investigation. The impact of NAFLD on the development of chronic kidney disease (CKD) is incompletely understood. The aim of this study was to explore the potential contribution of NAFLD on CKD in Germany. Methods The Disease Analyzer Database covering 7.49 million cases in Germany was explored for patients diagnosed with NAFLD between 2000 and 2015 and was matched 1:1 to a cohort without NAFLD. Matching criteria included age, sex, physician, index year and co-diagnoses associated with CKD. The primary outcomes of this study were incidences of CKD and end-stage renal disease. Results A total of 48,057 patients with NAFLD were matched to 48,057 patients without NAFLD. Within 10 years of the index date, 17.1% of patients with NAFLD and 11.6% of patients without NAFLD were diagnosed with CKD (p < 0.001). On Cox regression analysis, NAFLD was significantly associated with the incidence of CKD (hazard ratio (HR) = 1.58,p < 0.001). This association remained significant across different age groups and subgroups such as patients with diabetes mellitus or arterial hypertension. There was no association between NAFLD and emerging dialysis therapy (HR = 1.25,p = 0.245). Conclusions In this large database analysis in Germany, NAFLD constitutes an independent risk factor for CKD. Patients living with NAFLD should be monitored for a change in kidney function, facilitating therapeutic measures for kidney disease at an early stage.
C1 [Kaps, Leonard; Labenz, Christian; Galle, Peter R.; Weinmann-Menke, Julia; Schattenberg, Joern M.] Johannes Gutenberg Univ Mainz, Univ Med Ctr, Dept Med 1, Mainz, Germany.
   [Kaps, Leonard; Labenz, Christian; Galle, Peter R.; Schattenberg, Joern M.] Johannes Gutenberg Univ Mainz, Univ Med Ctr, Metab Liver Res Programme, Mainz, Germany.
   [Kostev, Karel] IQVIA, Epidemiol, Frankfurt, Germany.
C3 Johannes Gutenberg University of Mainz; Johannes Gutenberg University of
   Mainz; IQVIA
RP Schattenberg, JM (corresponding author), Johannes Gutenberg Univ Mainz, Univ Med Ctr, Dept Med 1, Metab Liver Res Programme, Langenbeckstr 1, D-55131 Mainz, Germany.
EM joern.schattenberg@unimedizin-mainz.de
RI Schattenberg, Jörn/C-1301-2013; Galle, Peter/ABE-2872-2021;
   Weinmann-Menke, Julia/X-7847-2019; Kostev, Karel/S-4755-2019
OI Galle, Peter Robert/0000-0001-8294-0992; Kostev,
   Karel/0000-0002-2124-7227; Weinmann-Menke, Julia/0000-0001-7344-8381;
   Schattenberg, Jorn M./0000-0002-4224-4703
FU University Medical Centre, Mainz, Germany
FX The authors disclosed receipt of the following financial support for the
   research, authorship and/or publication of this article: This work was
   funded in part by intramural funds of the University Medical Centre,
   Mainz, Germany.
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NR 23
TC 47
Z9 49
U1 0
U2 7
PU JOHN WILEY & SONS LTD
PI CHICHESTER
PA THE ATRIUM, SOUTHERN GATE, CHICHESTER PO19 8SQ, W SUSSEX, ENGLAND
SN 2050-6406
EI 2050-6414
J9 UNITED EUR GASTROENT
JI United European Gastroenterol. J.
PD OCT
PY 2020
VL 8
IS 8
BP 942
EP 948
AR 2050640620944098
DI 10.1177/2050640620944098
EA JUL 2020
PG 7
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA NT9HW
UT WOS:000551992800001
PM 32698692
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Booth, FW
   Roberts, CK
   Laye, MJ
AF Booth, Frank W.
   Roberts, Christian K.
   Laye, Matthew J.
TI Lack of Exercise Is a Major Cause of Chronic Diseases
SO COMPREHENSIVE PHYSIOLOGY
LA English
DT Article
ID BODY-MASS INDEX; ALL-CAUSE MORTALITY; TIME PHYSICAL-ACTIVITY;
   GROWTH-FACTOR-I; NEGATIVE-ENERGY BALANCE; LIFE-STYLE INTERVENTION;
   MODIFIABLE RISK-FACTORS; HUMAN SKELETAL-MUSCLE; FATTY LIVER-DISEASE;
   NUTRITION EXAMINATION SURVEY
AB Chronic diseases are major killers in the modern era. Physical inactivity is a primary cause of most chronic diseases. The initial third of the article considers: activity and prevention definitions; historical evidence showing physical inactivity is detrimental to health and normal organ functional capacities; cause versus treatment; physical activity and inactivity mechanisms differ; gene-environment interaction (including aerobic training adaptations, personalized medicine, and co-twin physical activity); and specificity of adaptations to type of training. Next, physical activity/exercise is examined as primary prevention against 35 chronic conditions [accelerated biological aging/premature death, low cardiorespiratory fitness (VO(2)max), sarcopenia, metabolic syndrome, obesity, insulin resistance, prediabetes, type 2 diabetes, nonalcoholic fatty liver disease, coronary heart disease, peripheral artery disease, hypertension, stroke, congestive heart failure, endothelial dysfunction, arterial dyslipidemia, hemostasis, deep vein thrombosis, cognitive dysfunction, depression and anxiety, osteoporosis, osteoarthritis, balance, bone fracture/falls, rheumatoid arthritis, colon cancer, breast cancer, endometrial cancer, gestational diabetes, pre-eclampsia, polycystic ovary syndrome, erectile dysfunction, pain, diverticulitis, constipation, and gallbladder diseases]. The article ends with consideration of deterioration of risk factors in longer-term sedentary groups; clinical consequences of inactive childhood/adolescence; and public policy. In summary, the body rapidly maladapts to insufficient physical activity, and if continued, results in substantial decreases in both total and quality years of life. Taken together, conclusive evidence exists that physical inactivity is one important cause of most chronic diseases. In addition, physical activity primarily prevents, or delays, chronic diseases, implying that chronic disease need not be an inevitable outcome during life. (C) 2012 American Physiological Society. Compr Physiol 2:1143-1211, 2012.
C1 [Booth, Frank W.] Univ Missouri, Dalton Cardiovasc Inst, Dept Biomed Sci, Columbia, MO 65211 USA.
   [Booth, Frank W.] Univ Missouri, Dalton Cardiovasc Inst, Dept Med Pharmacol & Physiol, Columbia, MO USA.
   [Booth, Frank W.] Univ Missouri, Dalton Cardiovasc Inst, Dept Nutr & Exercise Physiol, Columbia, MO USA.
   [Roberts, Christian K.] Univ Calif Los Angeles, Sch Nursing, Los Angeles, CA 90024 USA.
   [Roberts, Christian K.] Univ Calif Los Angeles, Ctr Metab Dis Prevent, Los Angeles, CA 90024 USA.
   [Laye, Matthew J.] Ctr Inflammat & Metab, Copenhagen, Denmark.
   [Laye, Matthew J.] Buck Inst Res Aging, Novato, CA USA.
C3 University of Missouri System; University of Missouri Columbia;
   University of Missouri System; University of Missouri Columbia;
   University of Missouri System; University of Missouri Columbia;
   University of California System; University of California Los Angeles;
   University of California System; University of California Los Angeles;
   Buck Institute for Research on Aging
RP Booth, FW (corresponding author), Univ Missouri, Dalton Cardiovasc Inst, Dept Biomed Sci, Columbia, MO 65211 USA.
EM boothf@missouri.edu
RI Laye, Matthew/AAQ-1897-2020
OI Laye, Matthew/0000-0003-3214-3113
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NR 576
TC 1702
Z9 2008
U1 23
U2 696
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 2040-4603
J9 COMPR PHYSIOL
JI Compr. Physiol.
PD APR
PY 2012
VL 2
IS 2
BP 1143
EP 1211
DI 10.1002/cphy.c110025
PG 69
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA 085YS
UT WOS:000314650800009
PM 23798298
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Ho, LC
   Wu, HT
   Hung, HC
   Chou, HW
   Cheng, KP
   Lin, CH
   Wang, CC
   Ou, HY
AF Ho, Li-Chung
   Wu, Hung-Tsung
   Hung, Hao-Chang
   Chou, Hsuan-Wen
   Cheng, Kai-Pi
   Lin, Ching-Han
   Wang, Chih-Chen
   Ou, Horng-Yih
TI Growth differentiation factor-15 is independently associated with
   metabolic syndrome and hyperglycemia in non-elderly subjects
SO BIOFACTORS
LA English
DT Article
DE diabetes; growth differentiation factor-15; hyperglycemia; metabolic
   syndrome; non-elderly subjects
ID CARDIOVASCULAR RISK; DYSFUNCTION
AB Metabolic syndrome (MetS) is a major health issue worldwide accompanied by cardiovascular comorbidities. Growth differentiation factor-15 (GDF-15) is a stress-responsive cytokine expressed in cardiomyocytes, adipocytes, macrophages, and endothelial cells. Previous research in elderly subjects revealed that GDF-15 levels were associated with the MetS. However, the association between GDF-15 levels and MetS or its components in the non-elderly subjects remains unclear. In this study, a total of 279 subjects younger than 65-year-old with (n = 84) or without (n = 195) MetS were recruited. MetS was defined according to modified NCEP/ATP III criteria. The GDF-15 levels were measured by an enzyme-linked immunosorbent assay. A multiple linear regression analysis was conducted to identify factors independently associated with GDF-15 levels. Subjects with MetS had higher GDF-15 levels than those without MetS (median (interquartile range), 1.72 ng/mL (1.38, 2.26) vs. 1.63 ng/mL (1.27, 2.07), P = 0.037). With the number of MetS components increased, the GDF-15 levels increased significantly (P for trend = 0.005). Multiple linear regression analysis revealed that the presence of MetS was positively associated with the GDF-15 levels (beta = 0.132, P = 0.037). When substituting MetS with its components, only the presence of hyperglycemia was positively associated with the GDF-15 levels after adjustment for covariates (beta = 0.193, P = 0.003). Taken together, the presence of the MetS in non-elderly was associated with higher GDF-15 levels. Among the MetS components, only hyperglycemia was significantly associated with the GDF-15 levels. Future longitudinal studies will be needed to explore whether GDF-15 has the potential to be a biomarker of gluco-metabolic dysfunction in non-elderly subjects.
C1 [Ho, Li-Chung; Chou, Hsuan-Wen; Cheng, Kai-Pi; Lin, Ching-Han; Ou, Horng-Yih] Natl Cheng Kung Univ, Natl Cheng Kung Univ Hosp, Coll Med, Dept Internal Med, Tainan, Taiwan.
   [Wu, Hung-Tsung; Ou, Horng-Yih] Natl Cheng Kung Univ, Coll Med, Sch Med, Dept Internal Med, 1 Univ Rd, Tainan 70101, Taiwan.
   [Hung, Hao-Chang] Kaohsiung Vet Gen Hosp, Dept Internal Med, Div Endocrinol & Metab, Kaohsiung, Taiwan.
   [Wang, Chih-Chen] Natl Cheng Kung Univ, Natl Cheng Kung Univ Hosp, Coll Med, Dept Internal Med,Dou Liou Branch, Tainan, Taiwan.
C3 National Cheng Kung University; National Cheng Kung University Hospital;
   National Cheng Kung University; Kaohsiung Veterans General Hospital;
   National Cheng Kung University; National Cheng Kung University Hospital
RP Ou, HY (corresponding author), Natl Cheng Kung Univ, Coll Med, Sch Med, Dept Internal Med, 1 Univ Rd, Tainan 70101, Taiwan.
EM wahoryi@mail.ncku.edu.tw
OI Wu, Hung-Tsung/0000-0002-0611-8427; Ou, Horng-Yih/0000-0002-3350-6548
FU Ministry of Science and Technology, Taiwan [108-2314-B-006-032-MY3,
   110-2314-B-006-115-MY3, 110-2314-B-006-116-MY3]
FX Ministry of Science and Technology, Taiwan, Grant/Award Numbers:
   108-2314-B-006-032-MY3, 110-2314-B-006-115-MY3, 110-2314-B-006-116-MY3
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NR 25
TC 6
Z9 6
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0951-6433
EI 1872-8081
J9 BIOFACTORS
JI Biofactors
PD JAN
PY 2023
VL 49
IS 1
BP 119
EP 126
DI 10.1002/biof.1871
EA JUN 2022
PG 8
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA Z2QQ1
UT WOS:000808373800001
PM 35686301
DA 2025-06-11
ER

PT J
AU Zhang, WJ
   Li, ZM
   Liu, M
   Mu, Y
   He, J
   Chen, P
   Liu, DD
   Chen, KH
   Che, BW
   Xu, SH
   Zhang, HY
   Tang, KF
AF Zhang, Wenjun
   Li, Zheming
   Liu, Miao
   Mu, Yi
   He, Jun
   Chen, Pan
   Liu, Dongdong
   Chen, Kehang
   Che, Bangwei
   Xu, Shenghan
   Zhang, Hongyan
   Tang, Kaifa
TI Potential role of glutathione S-transferase P1 gene polymorphism and
   metabolic syndrome in lower urinary tract symptoms attributed to benign
   prostatic hyperplasia
SO WORLD JOURNAL OF UROLOGY
LA English
DT Article
DE Glutathione S-transferase Pi; Gene polymorphism; Benign prostatic
   hyperplasia; Metabolic syndrome
ID OXIDATIVE STRESS; EXPRESSION; PI
AB Objective The aim of the study is to investigate the effects of glutathione S-transferase P1 (GSTP1) gene polymorphism and metabolic syndrome (MS) on lower urinary tract symptoms (LUTS) attributed to benign prostatic hyperplasia (BPH). Methods This study included 195 patients diagnosed with LUTS secondary to BPH as case group, divided into simple BPH group (S-BPH group) and combined with MS group (MS-BPH group). Control group included 200 healthy elderly men without LUTS. Use peripheral blood samples detected the GSTP1 gene polymorphism (Ile 105 Val A -> G polymorphism) by polymerase chain reaction-restriction fragment length polymorphism. Recorded age, GSTP1 gene polymorphism, international prostate symptom score (IPSS), prostate volume (PV), residual urine volume (RV), maximal urinary flowrate (Qmax), and prostate-specific antigen (PSA) to statistical analysis. Results Pairwise compared between control group, S-BPH group and MS-BPH, the PV (P < 0.001), PSA (P < 0.001), RV (P < 0.001), Qmax (P < 0.001), IPSS (P < 0.001), frequencies of GSTP1 gene (P < 0.05) were shown significant different, and MS-BPH group had larger PV, and more severe LUTS. In case group, variation genotypes (GSTP1 A/G + G/G) always had larger PV, higher PSA and IPSS, more RV and lower Qmax than homozygote (GSTP1 A/A) and the comparison were significant different (P < 0.05). Variation genotypes were positively correlated with PV (beta = 0.092, P < 0.001), RV (beta = 0.228, P = 0.004), IPSS (beta = 0.274, P = 0.038), PSA (beta = 1.243, P < 0.001) and negatively correlated with Qmax (beta = -0.362, P = 0.025). Conclusion In patients with BPH, GSTP1 variation genotypes and MS might be potential risk factors for faster progression of benign prostatic enlargement and LUTS, which might increase the surgical rate.
C1 [Zhang, Wenjun; Li, Zheming; Liu, Miao; Mu, Yi; He, Jun; Chen, Pan; Liu, Dongdong; Chen, Kehang; Che, Bangwei; Xu, Shenghan; Zhang, Hongyan; Tang, Kaifa] Affiliated Hosp Guizhou Med Univ, Dept Urol, Guiyang, Guizhou, Peoples R China.
   [Tang, Kaifa] Guizhou Med Univ, Inst Med Sci, Guiyang, Guizhou, Peoples R China.
C3 Guizhou Medical University; Guizhou Medical University
RP Zhang, HY; Tang, KF (corresponding author), Affiliated Hosp Guizhou Med Univ, Dept Urol, Guiyang, Guizhou, Peoples R China.; Tang, KF (corresponding author), Guizhou Med Univ, Inst Med Sci, Guiyang, Guizhou, Peoples R China.
EM zwenking@qq.com; zhemingli0106@qq.com; 453506609@qq.com;
   dogxiaobai@163.com; hejun0824@outlook.com; 562998720@qq.com;
   1773110317@qq.com; 294069802@qq.com; 156645087@qq.com;
   1974478700@qq.com; zhhyyn@163.com; tangkaifa@gmc.edu.cn
RI Liu, Dongdong/ADM-8738-2022; 刘, 淼/X-1216-2019
FU National Natural Science Fund of China [81660263]; Doctoral Fund of
   Affiliated Hospital of Guiyang Medical College, Guizhou Province, China
   [C-2012-6]
FX We would like to thank all the research participants of this study. The
   support by the National Natural Science Fund of China (Grant No.
   81660263) and Doctoral Fund of Affiliated Hospital of Guiyang Medical
   College, Guizhou Province, China (Grant No. C-2012-6).
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NR 30
TC 0
Z9 0
U1 0
U2 8
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0724-4983
EI 1433-8726
J9 WORLD J UROL
JI World J. Urol.
PD DEC
PY 2021
VL 39
IS 12
BP 4413
EP 4419
DI 10.1007/s00345-021-03778-3
EA JUL 2021
PG 7
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA XA2SP
UT WOS:000670218600001
PM 34228163
DA 2025-06-11
ER

PT J
AU Wang, XL
   Shan, XD
   Dun, YL
   Cai, C
   Hao, JJ
   Li, GY
   Cui, KY
   Yu, GL
AF Wang, Xueliang
   Shan, Xindi
   Dun, Yunlou
   Cai, Chao
   Hao, Jiejie
   Li, Guoyun
   Cui, Kaiyun
   Yu, Guangli
TI Anti-Metabolic Syndrome Effects of Fucoidan from Fucus
   vesiculosus via Reactive Oxygen Species-Mediated Regulation of JNK,
   Akt, and AMPK Signaling
SO MOLECULES
LA English
DT Article
DE fucoidan; metabolic syndrome; ROS; insulin resistance; AMPK signaling
   pathway; lipid metabolism
ID ACTIVATED PROTEIN-KINASE; ENDOPLASMIC-RETICULUM STRESS;
   INSULIN-RESISTANCE; GUT MICROBIOTA; ACID SYNTHESIS; LIVER-INJURY;
   POLYSACCHARIDES; OBESITY; PHOSPHORYLATION; ASSOCIATION
AB Recent studies have reported that dietary fiber improved metabolic syndrome (MetS). However, the effects of fucoidans on MetS were still not clear. In this study, we evaluated the activity of fucoidan from Fucus vesiculosus (FvF) on attenuating MetS and first elucidated the underlying mechanism. In vitro, FvF treatment remarkably lowered the level of reactive oxygen species (ROS) compared with the sodium palmitate (PA)-induced insulin resistance (IR) group. The phosphorylation level of c-Jun N-terminal kinase (JNK) was significantly decreased, while phosphorylation of protein kinase B (pAkt) level increased, compared with that of the HepG2 cells treated with PA. Thus, FvF increased glucose consumption and relieved IR via ROS-mediated JNK and Akt signaling pathways. In addition, these changes were accompanied by the activation of adenosine 5 '-monophosphate-ativated protein kinase (AMPK) and its downstream targets (e.g., HMG-CoA reductase (HMGCR), acetyl-CoA carboxylase (ACC), and sterol-regulatory element-binding protein-1c (SREBP-1C)), which improved lipid metabolism in IR HepG2 cells. In vivo, FvF improved hyperglycemia and decreased serum insulin level in mice with MetS. Furthermore, we evaluated the inhibition of glucose transport by in vitro (Caco-2 monolayer model), semi-in vivo (everted gut sac model) and oral glucose tolerance test (OGTT), which indicated that FvF could significantly reduce the absorption of glucose into the blood stream, thus it could improve blood-glucose levels and IR in mice with MetS. Moreover, FvF decreased serum triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) levels and liver lipid accumulation, while increased the serum high density lipoprotein cholesterol (HDL-C) level in mice with MetS. Therefore, FvF could be considered as a potential candidate for the treatment of MetS by alleviating IR, inhibiting glucose transportation, and regulating lipid metabolism.
C1 [Wang, Xueliang; Shan, Xindi; Dun, Yunlou; Cai, Chao; Hao, Jiejie; Li, Guoyun; Cui, Kaiyun; Yu, Guangli] Ocean Univ China, Sch Med & Pharm, Shandong Prov Key Lab Glycosci & Glycotechnol, Key Lab Marine Drugs,Minist Educ, Qingdao 266003, Shandong, Peoples R China.
   [Wang, Xueliang; Shan, Xindi; Dun, Yunlou; Cai, Chao; Hao, Jiejie; Li, Guoyun; Cui, Kaiyun; Yu, Guangli] Pilot Natl Lab Marine Sci & Technol Qingdao, Lab Marine Drugs & Bioprod, Qingdao 266237, Shandong, Peoples R China.
C3 Ocean University of China; Ministry of Education - China; Laoshan
   Laboratory
RP Hao, JJ; Yu, GL (corresponding author), Ocean Univ China, Sch Med & Pharm, Shandong Prov Key Lab Glycosci & Glycotechnol, Key Lab Marine Drugs,Minist Educ, Qingdao 266003, Shandong, Peoples R China.; Hao, JJ; Yu, GL (corresponding author), Pilot Natl Lab Marine Sci & Technol Qingdao, Lab Marine Drugs & Bioprod, Qingdao 266237, Shandong, Peoples R China.
EM 2009haojie@ouc.edu.cn; glyu@ouc.edu.cn
RI zhang, chenhong/HCH-9822-2022; Wang, Xueliang/AAY-7112-2021; Shan,
   Xindi/ABE-5237-2020
OI SHAN, XINDI/0000-0003-3951-8766; Cai, Chao/0000-0003-4377-3989; YU,
   GUANGLI/0000-0002-6372-9750
FU National Natural Science Foundation of China [31670811, 81402982];
   National Science and Technology Major Project of China
   [2018ZX09735-004]; NSFC-Shandong Joint Fund for Marine Science Research
   Centers [U1606403]; Qingdao National Laboratory for Marine Science and
   Technology [2016ASKJ08-2]; Taishan Scholar Project Special Funds
   [TS201511011]; Shandong Provincial Major Science and Technology
   Innovation Project [2018SDKJ0404]
FX This work was supported by National Natural Science Foundation of China
   (31670811, 81402982), National Science and Technology Major Project of
   China (2018ZX09735-004), NSFC-Shandong Joint Fund for Marine Science
   Research Centers (U1606403), Qingdao National Laboratory for Marine
   Science and Technology (2016ASKJ08-2), Taishan Scholar Project Special
   Funds (TS201511011), Shandong Provincial Major Science and Technology
   Innovation Project (2018SDKJ0404).
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NR 52
TC 23
Z9 24
U1 4
U2 60
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1420-3049
J9 MOLECULES
JI Molecules
PD SEP
PY 2019
VL 24
IS 18
AR 3319
DI 10.3390/molecules24183319
PG 17
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA JB8ON
UT WOS:000488830500111
PM 31547311
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Rizzo, M
   Rizvi, AA
   Patti, AM
   Nikolic, D
   Giglio, RV
   Castellino, G
   Li Volti, G
   Caprio, M
   Montalto, G
   Provenzano, V
   Genovese, S
   Ceriello, A
AF Rizzo, Manfredi
   Rizvi, Ali A.
   Patti, Angelo Maria
   Nikolic, Dragana
   Giglio, Rosaria Vincenza
   Castellino, Giuseppa
   Li Volti, Giovanni
   Caprio, Massimiliano
   Montalto, Giuseppe
   Provenzano, Vincenzo
   Genovese, Stefano
   Ceriello, Antonio
TI Liraglutide improves metabolic parameters and carotid intima-media
   thickness in diabetic patients with the metabolic syndrome: an 18-month
   prospective study
SO CARDIOVASCULAR DIABETOLOGY
LA English
DT Article
DE Liraglutide; Cardiovascular risk; Carotid intima-media thickness;
   Metabolic syndrome
ID CARDIOVASCULAR OUTCOMES; INFLAMMATORY MARKERS; OXIDATIVE STRESS;
   PEPTIDE-1 ANALOG; GLP-1 ANALOGS; TYPE-2; METFORMIN; SAFETY; EFFICACY;
   MELLITUS
AB Background: Liraglutide, a GLP-1 analogue, exerts several beneficial non-glycemic effects in patients with type-2 diabetes (T2DM), such as those on body weight, blood pressure, plasma lipids and inflammation markers. However, the effects of liraglutide on cardiovascular (CV) risk markers in subjects with the metabolic syndrome (MetS) are still largely unknown. We herein explored its effects on various cardio-metabolic risk markers of the MetS in subjects with T2DM.
   Methods: We performed an 18-month prospective, real-world study. All subjects had T2DM and the MetS based on the AHA/NHLBI criteria. Subjects with a history of a major CV event were excluded. One hundred-twenty-one subjects (71 men and 50 women; mean age: 62 +/- 9 years) with T2DM and the MetS, who were naive to incretin-based therapies and treated with metformin only, were included. Liraglutide (1.2 mg/day) was added to metformin (1500-3000 mg/day) for the entire study. Fasting plasma samples for metabolic parameters were collected and carotid-intima media thickness (cIMT) was assessed by B-mode real-time ultrasound at baseline and every 6 months thereafter.
   Results: There was a significant reduction in waist circumference, body mass index, fasting glycemia, HbA1c, total and LDL-cholesterol, triglycerides, and cIMT during the 18-month follow-up. Correlation analysis showed a significant association between changes in cIMT and triglycerides (r = 0.362; p < 0.0001). The MetS prevalence significantly reduced during the study, and the 26% of subjects no longer fulfilled the criteria for the MetS after 18 months.
   Conclusions: Liraglutide improves cardio-metabolic risk factors in subjects with the MetS in a real-world study.
C1 [Rizzo, Manfredi; Patti, Angelo Maria; Nikolic, Dragana; Giglio, Rosaria Vincenza; Castellino, Giuseppa; Montalto, Giuseppe] Univ Palermo, Biomed Dept Internal Med & Med Specialties, Palermo, Italy.
   [Rizzo, Manfredi; Rizvi, Ali A.] Univ South Carolina, Sch Med, Div Endocrinol Diabet & Metab, Columbia, SC USA.
   [Li Volti, Giovanni] Univ Catania, Dept Biomed & Biotechnol Sci, Catania, Italy.
   [Caprio, Massimiliano] IRCCS San Raffaele Pisana, Lab Cardiovasc Endocrinol, Rome, Italy.
   [Caprio, Massimiliano] San Raffaele Roma Open Univ, Dept Human Sci & Promot Qual Life, Rome, Italy.
   [Montalto, Giuseppe] CNR, Inst Biomed & Mol Immunol Alberto Monroy, Palermo, Italy.
   [Provenzano, Vincenzo] Partinico Hosp, Dept Internal Med, Reg Ctr Diabetol, Partinico, Italy.
   [Genovese, Stefano; Ceriello, Antonio] IRCCS MultiMed, Milan, Italy.
   [Ceriello, Antonio] Hosp Clin Barcelona, Insititut Invest Biomed August Pi I Sunyer, Diabet & Endocrinol, Barcelona, Spain.
   [Ceriello, Antonio] Hosp Clin Barcelona, Ctr Invest Biomed Red Diabet & Enfermedad Metab A, Barcelona, Spain.
C3 University of Palermo; University of South Carolina System; University
   of South Carolina Columbia; University of Catania; IRCCS San Raffaele
   Pisana; Consiglio Nazionale delle Ricerche (CNR); Istituto di
   Biomedicina e di Immunologia Molecolare "Alberto Monroy" (IBIM-CNR);
   IRCCS Multimedica; University of Barcelona; Hospital Clinic de
   Barcelona; CIBER - Centro de Investigacion Biomedica en Red; CIBERDEM;
   University of Barcelona; Hospital Clinic de Barcelona
RP Nikolic, D (corresponding author), Univ Palermo, Biomed Dept Internal Med & Med Specialties, Palermo, Italy.
EM draggana.nikolic@gmail.com
RI RIZZO, MANFREDI/GZL-0551-2022; Ceriello, Antonio/J-9575-2016; GIGLIO,
   Rosaria Vincenza/IAR-9444-2023; Volti, Giovanni/A-2435-2008; Rizvi,
   Ali/AFV-2240-2022; Castellino, Giuseppa/AAF-4272-2020; Licata,
   Anna/ADF-0000-2022; Genovese, Stefano/F-9706-2017; Caprio,
   Massimiliano/J-3020-2012
OI Genovese, Stefano/0000-0002-6085-437X; GIGLIO, Rosaria
   Vincenza/0000-0002-7968-1480; Caprio, Massimiliano/0000-0003-0722-7163;
   Li Volti, Giovanni/0000-0002-8678-2183; Nikolic,
   Dragana/0000-0001-9572-9651
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NR 43
TC 107
Z9 110
U1 0
U2 10
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1475-2840
J9 CARDIOVASC DIABETOL
JI Cardiovasc. Diabetol.
PD DEC 3
PY 2016
VL 15
AR 162
DI 10.1186/s12933-016-0480-8
PG 8
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism
GA EH6NN
UT WOS:000391889900001
PM 27912784
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Sabe, AA
   Elmadhun, NY
   Sadek, AA
   Chu, LM
   Bianchi, C
   Sellke, FW
AF Sabe, Ashraf A.
   Elmadhun, Nassrene Y.
   Sadek, Ahmed A.
   Chu, Louis M.
   Bianchi, Cesario
   Sellke, Frank W.
TI Differential effects of atorvastatin on autophagy in ischemic and
   nonischemic myocardium in Ossabaw swine with metabolic syndrome
SO JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
LA English
DT Article
ID ANGIOGENESIS; STATINS; INHIBITION; RESVERATROL
AB Objectives: The perioperative administration of pleomorphic statin drugs has been implicated in improving outcomes after cardiac surgery. Adaptive autophagy is a highly conserved cellular process that allows for the elimination of dysfunctional cell components in response to stress and survival under starving conditions. We sought to investigate the effects of the statin drug atorvastatin on autophagy in ischemic and nonischemic myocardia using a clinically relevant porcine model of metabolic syndrome.
   Methods: Male Ossabaw swine were fed a regular diet (n = 8), a high-cholesterol diet (n = 8), or a high-cholesterol diet with supplemental atorvastatin (1.5 mg/kg/d) (n = 8). After 14 weeks, all animals underwent surgical placement of an ameroid constrictor to the circumflex coronary artery to induce chronic ischemia. Nonischemic and ischemic myocardia were harvested 6 months after initiation of the diet and processed for Western blotting.
   Results: In the nonischemic myocardium, Western blot results demonstrate that a high cholesterol diet resulted in a statistically significant decrease in autophagy as indicated by an increase in mammalian target of rapamycin and the accumulation of several essential autophagy markers, including Beclin-1, light chain 3B-I, and light chain 3B-II. Atorvastatin supplementation prevented these changes and resulted in an increase in autophagy as indicated by a decrease in autophagy flux marker P62. In the ischemic myocardium, atorvastatin had the opposite effect, with a decrease in autophagy flux as indicated by an increase in p62 and an accumulation of light chain 3B-I, light chain B-II, and lysosome-associated membrane protein 2.
   Conclusions: Atorvastatin administration has differential effects on autophagy in ischemic and nonischemic myocardia. In the setting of metabolic syndrome, atorvastatin stimulates autophagy in nonischemic myocardium while partly inhibiting autophagy in ischemic myocardium. The differential regulation on autophagy may, in part, explain the cardioprotective effect of statins in both ischemic and nonischemic myocardia, and these findings may have implications in the setting of cardiac surgery.
C1 [Sabe, Ashraf A.; Elmadhun, Nassrene Y.; Sadek, Ahmed A.; Chu, Louis M.; Bianchi, Cesario; Sellke, Frank W.] Brown Univ, Div Cardiothorac Surg, Cardiovasc Res Ctr, Warren Alpert Med Sch, Providence, RI 02905 USA.
C3 Brown University
RP Sellke, FW (corresponding author), Brown Univ, Div Cardiothorac Surg, Cardiovasc Res Ctr, Warren Alpert Med Sch, 2 Dudley St,MOC 360, Providence, RI 02905 USA.
EM fsellke@lifespan.org
RI bianchi, cesario/H-6238-2012
FU CSL Behring; Medicines Company
FX Frank W. Sellke reports consulting fees from CSL Behring and the
   Medicines Company. All other authors have nothing to disclose with
   regard to commercial support.
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NR 35
TC 22
Z9 25
U1 0
U2 13
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0022-5223
EI 1097-685X
J9 J THORAC CARDIOV SUR
JI J. Thorac. Cardiovasc. Surg.
PD DEC
PY 2014
VL 148
IS 6
BP 3172
EP 3178
DI 10.1016/j.jtcvs.2014.07.104
PG 7
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA AU6BD
UT WOS:000345686100154
PM 25240527
OA Bronze, Green Accepted
DA 2025-06-11
ER

PT J
AU Ding, YH
   Ma, Y
   Qian, LY
   Xu, Q
   Wang, LH
   Huang, DS
   Zou, H
AF Ding, Ya-Hui
   Ma, Yuan
   Qian, Lin-Yan
   Xu, Qiang
   Wang, Li-Hong
   Huang, Dong-Sheng
   Zou, Hai
TI Linking atrial fibrillation with non-alcoholic fatty liver disease:
   potential common therapeutic targets
SO ONCOTARGET
LA English
DT Review
DE non-alcoholic fatty liver disease; atrial fibrillation; adiponectin;
   insulin resistance; renin angiotensin aldosterone system
ID CORONARY-HEART-DISEASE; CIRCULATING ADIPONECTIN LEVELS;
   ANGIOTENSIN-CONVERTING ENZYME; MOLECULAR-WEIGHT ADIPONECTIN; INCREASED
   ENERGY-EXPENDITURE; INSULIN-RESISTANCE; METABOLIC SYNDROME; HEPATIC
   STEATOSIS; OXIDATIVE STRESS; DIABETES-MELLITUS
AB Non-alcoholic fatty liver disease (NAFLD) and atrial fibrillation (AF) are common chronic non-infectious diseases with rising incidences. NAFLD is an independent risk factor for the onset of AF, after adjusting potentially related factors. The pathogenesis of these diseases share several mechanisms including reduced adiponectin level, insulin resistance, and renin angiotensin aldosterone system (RAAS) activation, in addition to activation of common disease pathways that promote inflammation, oxidative stress, and fibrosis. Furthermore, statins and RAAS blockers exert therapeutic effects concurrently on NAFLD and AF. The common pathogenesis of NAFLD and AF may serve as a potential therapeutic target in the future.
C1 [Ding, Ya-Hui; Ma, Yuan; Qian, Lin-Yan; Xu, Qiang; Wang, Li-Hong; Zou, Hai] Zhejiang Prov Peoples Hosp, Dept Cardiol, Hangzhou 310014, Zhejiang, Peoples R China.
   [Huang, Dong-Sheng] Zhejiang Prov Peoples Hosp, Dept Hepatobiliary Surg, Hangzhou 310014, Zhejiang, Peoples R China.
   [Ding, Ya-Hui; Ma, Yuan; Qian, Lin-Yan; Xu, Qiang; Wang, Li-Hong; Huang, Dong-Sheng; Zou, Hai] Hangzhou Med Coll, Peoples Hosp, Hangzhou 310014, Zhejiang, Peoples R China.
C3 Hangzhou Medical College; Zhejiang Provincial People's Hospital;
   Hangzhou Medical College; Zhejiang Provincial People's Hospital;
   Hangzhou Medical College
RP Xu, Q; Wang, LH; Zou, H (corresponding author), Zhejiang Prov Peoples Hosp, Dept Cardiol, Hangzhou 310014, Zhejiang, Peoples R China.; Huang, DS (corresponding author), Zhejiang Prov Peoples Hosp, Dept Hepatobiliary Surg, Hangzhou 310014, Zhejiang, Peoples R China.; Xu, Q; Wang, LH; Huang, DS; Zou, H (corresponding author), Hangzhou Med Coll, Peoples Hosp, Hangzhou 310014, Zhejiang, Peoples R China.
EM xuqiang@zjheart.com; wanglh@zjheart.com; dshuang@zju.edu.cn;
   haire1993@163.com
RI zou, hai/GLV-6798-2022
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NR 116
TC 13
Z9 13
U1 0
U2 9
PU IMPACT JOURNALS LLC
PI ORCHARD PARK
PA 6666 E QUAKER ST, STE 1, ORCHARD PARK, NY 14127 USA
EI 1949-2553
J9 ONCOTARGET
JI Oncotarget
PD SEP 1
PY 2017
VL 8
IS 36
BP 60673
EP 60683
DI 10.18632/oncotarget.19522
PG 11
WC Oncology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Cell Biology
GA FF4RQ
UT WOS:000408944300053
PM 28948002
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Gulati, M
   McBride, PE
AF Gulati, M
   McBride, PE
TI Functional capacity and cardiovascular assessment: Submaximal exercise
   testing and hidden candidates for pharmacologic stress
SO AMERICAN JOURNAL OF CARDIOLOGY
LA English
DT Article; Proceedings Paper
CT Symposium on Assessing Cardiac Risk
CY JAN 21, 2005
CL Laguna Beach, CA
ID CORONARY-ARTERY-DISEASE; EMISSION COMPUTED-TOMOGRAPHY; INCREMENTAL
   PROGNOSTIC VALUE; MYOCARDIAL-PERFUSION; METABOLIC SYNDROME;
   HEART-DISEASE; PHYSICAL-FITNESS; TASK-FORCE; WOMEN; ADENOSINE
AB Submaximal exercise testing is often used to estimate functional capacity in nonathletes, to assess cardiovascular disease in elderly or frail patients, to demonstrate exercise equipment, or to risk-stratify patients after myocardial infarction. However, submaximal exercise testing is not sufficiently sensitive, specific, or predictive to have widespread clinical utility, except in post-myocardial infarction protocols. Many patients for whom submaximal exercise testing is not useful are unable to exercise sufficiently for maximal testing and are referred for imaging with pharmacologic stress. Although some patients who are unable to exercise adequately are easily recognized, many are not. The identification of such patients before they fail a maximal exercise test attempt is beneficial to both the patient and the imaging laboratory. (c) 2005 Elsevier Inc. All rights reserved.
C1 Northwestern Univ, Bluhm Cardiovasc Inst, Chicago, IL USA.
   Univ Wisconsin, Dept Med, Madison, WI USA.
   Univ Wisconsin, Dept Family Med, Madison, WI USA.
C3 Northwestern University; University of Wisconsin System; University of
   Wisconsin Madison; University of Wisconsin System; University of
   Wisconsin Madison
RP NW Memorial Hosp, Div Cardiol, 201 E Huron,Suite 10-240, Chicago, IL 60611 USA.
EM mgulati@nmff.org
RI Gulati, Martha/AAB-7722-2022
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NR 57
TC 7
Z9 9
U1 0
U2 0
PU EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
PI BRIDGEWATER
PA 685 ROUTE 202-206 STE 3, BRIDGEWATER, NJ 08807 USA
SN 0002-9149
EI 1879-1913
J9 AM J CARDIOL
JI Am. J. Cardiol.
PD OCT 17
PY 2005
VL 96
IS 8A
SU S
BP 11J
EP 19J
DI 10.1016/j.amjcard.2005.06.016
PG 9
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Cardiovascular System & Cardiology
GA 979ON
UT WOS:000232954800003
PM 16246649
DA 2025-06-11
ER

PT J
AU Varade, S
   Nadella, M
   Hirake, A
   Mungas, SB
   Ali, A
   Adela, R
AF Varade, Shruti
   Nadella, Mounika
   Hirake, Amol
   Mungas, Suraj Bhausaheb
   Ali, Amir
   Adela, Ramu
TI Effect of garlic on the components of metabolic syndrome: A systematic
   review and meta-analysis of randomized controlled trials
SO JOURNAL OF ETHNOPHARMACOLOGY
LA English
DT Review
DE Garlic; Metabolic diseases; Anti-hyperglycemic; Anti-hypertensive;
   Anti-inflammatory
ID CARDIOVASCULAR RISK-FACTORS; TYPE-2 DIABETES-MELLITUS; ACTIVATED
   PROTEIN-KINASE; INSULIN-RESISTANCE; ENDOTHELIAL FUNCTION; OXIDATIVE
   STRESS; LIPID PARAMETERS; ALLIUM-SATIVUM; POWDER TABLETS; BLOOD-PRESSURE
AB Ethnopharmacological relevance: Metabolic diseases are the major causes of macrovascular and microvascular complications which lead to morbidity and mortality. Traditionally, garlic has been used as food and medicine for more than 5000 years. However, efficacy studies have shown conflicting results regarding the garlic effect.
   Aim of the study: This study aims to evaluate the efficacy of garlic on the components of metabolic syndrome (MetS) in metabolic disease patients.
   Materials and methods: This study was a systematic review and meta-analysis of randomized controlled trials (RCTs). Pubmed, Cochrane Central Register of Controlled Trials (CENTRAL), and Google scholar were searched till December 25, 2021 for identifying the relevant studies that have shown the effects of garlic on components of metabolic syndrome in metabolic disease patients. The mean difference with 95% CI was calculated using fixed-effect or random-effect models.
   Results: The effect of garlic has shown significant changes on waist circumference (p-value= < 0.0001), total cholesterol (p < 0.0001), low density lipoprotein (p = 0.01), high density lipoprotein (p < 0.00001), triglycerides (p < 0.00001), systolic blood pressure (p < 0.00001), diastolic blood pressure (p < 0.00001), glucose (p < 0.00001), Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) (p = 0.04), C-reactive protein (p < 0.00001), tumor necrosis factor (TNF)-a (p = 0.002), interleukin (IL)-6 (p = 0.0001). Subgroup analysis has shown the favorable effects of garlic in metabolic disease patients.
   Conclusion: Our meta-analysis results confirm the findings that garlic could be useful as an anti-hyperlipidemic, anti-hyperglycemic, anti-hypertensive and anti-inflammatory drug.
C1 [Varade, Shruti; Nadella, Mounika; Hirake, Amol; Mungas, Suraj Bhausaheb; Ali, Amir; Adela, Ramu] NIPER Guwahati, Dept Pharm Practice, Changsari PO, Gauhati 781101, Assam, India.
C3 National Institute of Pharmaceutical Education & Research, S.A.S. Nagar
   (Mohali)
RP Adela, R (corresponding author), NIPER Guwahati, Dept Pharm Practice, Changsari PO, Gauhati 781101, Assam, India.
EM shrutivarade7@gmail.com; nadellamounika08@gmail.com;
   amolhirake@gmail.com; surajmungase98@gmail.com; amirklg1990@gmail.com;
   ramu@niperguwahati.in
RI Adela, Ramu/HKO-9169-2023
OI Mungase, Suraj Bhausaheb/0009-0004-3069-2703
FU Department of Pharmaceuticals (DoP) , Ministry of Chemicals and
   Fertilizers, Govt. of India; Institutional Core Grant, NIPER-Guwahati
FX This research study was funded by the Institutional Core Grant,
   NIPER-Guwahati and Department of Pharmaceuticals (DoP), Ministry of
   Chemicals and Fertilizers, Govt. of India.
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NR 94
TC 9
Z9 9
U1 0
U2 16
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0378-8741
EI 1872-7573
J9 J ETHNOPHARMACOL
JI J. Ethnopharmacol.
PD JAN 10
PY 2024
VL 318
AR 116960
DI 10.1016/j.jep.2023.116960
EA AUG 2023
PN B
PG 16
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA S3JB2
UT WOS:001070153800001
PM 37517570
DA 2025-06-11
ER

PT J
AU Manfredi, JM
   Stapley, ED
   Nadeau, JA
   Nash, D
AF Manfredi, Jane M.
   Stapley, Emma D.
   Nadeau, Jenifer A.
   Nash, Delia
TI Investigation of the Effects of a Dietary Supplement on Insulin and
   Adipokine Concentrations in Equine Metabolic Syndrome/Insulin
   Dysregulation
SO JOURNAL OF EQUINE VETERINARY SCIENCE
LA English
DT Article
DE Resveratrol and leucine; Equine metabolic syndrome; HMW adiponectin;
   Dietary supplement; Insulin dysregulation; Oral sugar test
ID MOLECULAR-WEIGHT ADIPONECTIN; ORAL SUGAR TEST; OXIDATIVE STRESS; GLUCOSE
   DYNAMICS; OBESITY; HYPERINSULINEMIA; METFORMIN; AGE; PHARMACOKINETICS;
   RESVERATROL
AB High insulin concentrations are a common clinical feature of equine metabolic syndrome (EMS) and insulin dysregulation. Hyperinsulinemia can induce laminitis, so reduction of insulin concentrations in response to an oral challenge should decrease risk. In human studies, diets containing a polyphenol (resveratrol) led to improvements in insulin sensitivity. In rodents, the addition of leucine to a resveratrol supplement caused a decrease in the amount of resveratrol needed to achieve a clinical effect. We hypothesize a supplementation with a low dose of a synergistic polyphenol and amino acid blend including leucine (SPB+L) would improve metabolic health in EMS/insulin dysregulated horses. Fifteen EMS/ID horses received a high or low dose of SPB+ L daily for 6 weeks. Insulin during an oral sugar test (OST), body condition score, weight, baseline high-molecular-weight (HMW) adiponectin, triglycerides, nonesterifled fatty acids, and tumor necrosis factor alpha were assessed before supplementation (PRE) and after supplementation (POST) via paired Student's t-tests and a repeated-measures mixed-model analysis of variance (significant at P < .05). There were no differences between doses. Horses in the POST group weighed significantly less, had significantly higher baseline HMW adiponectin concentrations, and had significantly lower insulin concentrations at 60- and 75-minute time points (P < .05). Insulin concentrations of the horsesin the POST group, but not in the PRE group, were lower and similar to results from the study conducted three years before the present study (PRIOR) for 0- and 60-minute time points (P < .002). An increased HMW adiponectin level supports increasing insulin sensitivity after supplementation. These results suggest that SPB + L supplementation at either dose leads to improvements in the clinical manifestations of EMS/insulin dysregulation, potentially reducing laminitis risk. (C) 2020 Elsevier Inc. All rights reserved.
C1 [Manfredi, Jane M.; Stapley, Emma D.] Michigan State Univ, Coll Vet Med, Dept Pathobiol & Diagnost Invest, 784 Wilson Rd, E Lansing, MI 48824 USA.
   [Nadeau, Jenifer A.] Univ Connecticut, Dept Anim Sci, Storrs, CT USA.
   [Nash, Delia] Kentucky Performance Prod, Versailles, KY USA.
C3 Michigan State University; University of Connecticut
RP Manfredi, JM (corresponding author), Michigan State Univ, Coll Vet Med, Dept Pathobiol & Diagnost Invest, 784 Wilson Rd, E Lansing, MI 48824 USA.
EM manfred1@msu.edu
RI Manfredi, Jane/A-2104-2015
FU Kentucky Performance Products (Versailles, KY); Boehringer-Ingelheim
   Veterinary Scholars Program; MSU Graduate School Fellowship; Morris
   Animal Foundation Research Training Fellowship [D14EQ-401]
FX This project was supported by Kentucky Performance Products (Versailles,
   KY) and the Boehringer-Ingelheim Veterinary Scholars Program and the MSU
   Graduate School Fellowship (E. Stapley). Dr Manfredi was supported by a
   Morris Animal Foundation Research Training Fellowship (D14EQ-401) for
   part of the PRIOR data collection.
CR [Anonymous], 2014, Bioenergetics, DOI [10.4172/2167-7662.1000120, DOI 10.4172/2167-7662.1000120]
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   [Anonymous], J EQUINE VET SCI
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NR 49
TC 10
Z9 10
U1 1
U2 17
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0737-0806
EI 1542-7412
J9 J EQUINE VET SCI
JI J. Equine Vet. Sci.
PD MAY
PY 2020
VL 88
AR 102930
DI 10.1016/j.jevs.2020.102930
PG 6
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA LE1XW
UT WOS:000526518500013
PM 32303322
DA 2025-06-11
ER

PT J
AU Karot, SS
   Surenahalli, VG
   Kishore, A
   Mudgal, J
   Nandakumar, K
   Chirayil, MT
   Mathew, G
   Nampurath, GK
AF Karot, Sarine Sebastian
   Surenahalli, Vasantharaju Gowdra
   Kishore, Anoop
   Mudgal, Jayesh
   Nandakumar, Krishnadas
   Chirayil, Magith Thambi
   Mathew, Geetha
   Nampurath, Gopalan Kutty
TI Dose-related antihyperglycemic and hypolipidemic effects of two novel
   thiazolidin-4-ones in a rodent model of metabolic syndrome
SO JOURNAL OF DIABETES
LA English
DT Article
DE antihyperglycemic; anti-inflammatory; hypolipidemic; metabolic syndrome;
   thiazolidin-4-one
ID HIGH-FAT DIET; MONOSODIUM GLUTAMATE; CARDIOVASCULAR-DISEASE;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; OBESITY; RATS; FRUCTOSE; MICE
AB BackgroundThe replacement of the thiazolidinedione moiety with a thiazolidinone may yield antidiabetic compounds with similar pleiotropic effects. Hence, the aim of the present study was to explore the dose-related antihyperglycemic and hypolipidemic effects of two synthesized novel thiazolidin-4-one derivatives, one with a nicotinamide and the other with a p-chlorophenoxyacetamide substitution at the N3 position of the thiazolidinone ring (NAT1 and PAT1, respectively), in a rodent model of metabolic syndrome (MetS).
   MethodsMetabolic syndrome was induced in Wistar rats by neonatal administration of monosodium glutamate (i.p.) on 4 consecutive days followed by high-sucrose diet feeding for 6months. The effects of NAT1 (33 and 66mg/kg) and molar equivalent doses of PAT1 (40 and 80mg/kg) on relevant biochemical parameters were evaluated. Because MetS is a state of chronic low-grade inflammation, we also evaluated the effects of these compounds on proinflammatory markers, namely interleukin (IL)-6, tumor necrosis factor (TNF)-, reactive oxygen species (ROS), and nitric oxide (NO).
   ResultsBoth NAT1 and PAT1 attenuated hyperglycemia, hypertriglyceridemia, hypoalphalipoproteinemia, and glucose intolerance. PAT1 exhibited superior antihyperglycemic and antihypoalphalipoproteinemic effects than NAT1. However, NAT1 had a better triglyceride-lowering effect. At the lower dose tested, both compounds significantly reduced elevated malondialdehyde levels. In addition, PAT1 (80mg/kg) restored hepatic superoxide dismutase enzyme levels. There was a tendency for NAT1 and PAT1 to inhibit elevated hepatic IL-6 and TNF- levels, but the differences did not reach statistical significance. In addition, PAT1 exhibited in vitro anti-inflammatory activity by reducing proinflammatory ROS and NO levels in RAW264.7 macrophages.
   ConclusionsThe novel thiazolidin-4-ones NAT1 and PAT1 could be potential pleiotropic drug candidates targeting MetS.
C1 [Karot, Sarine Sebastian; Kishore, Anoop; Mudgal, Jayesh; Nandakumar, Krishnadas; Chirayil, Magith Thambi; Mathew, Geetha; Nampurath, Gopalan Kutty] Manipal Univ, Dept Pharmacol, Manipal Coll Pharmaceut Sci, Manipal 576104, Karnataka, India.
   [Surenahalli, Vasantharaju Gowdra] Manipal Univ, Dept Pharmaceut Qual Assurance, Manipal Coll Pharmaceut Sci, Manipal, Karnataka, India.
C3 Manipal Academy of Higher Education (MAHE); Manipal Academy of Higher
   Education (MAHE)
RP Nampurath, GK (corresponding author), Manipal Univ, Dept Pharmacol, Manipal Coll Pharmaceut Sci, Manipal 576104, Karnataka, India.
EM ng.kutty@manipal.edu
RI Kishore, Anoop/H-5052-2019; G, Vasantharaju/AAH-9612-2021; Nandakumar,
   Krishnadas/H-3420-2019; Mudgal, Jayesh/H-4733-2019
OI Mathew, Geetha/0000-0002-2154-2672; Nandakumar,
   Krishnadas/0000-0001-6653-4660; Mudgal, Jayesh/0000-0001-8190-7031
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NR 45
TC 2
Z9 2
U1 0
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1753-0393
EI 1753-0407
J9 J DIABETES
JI J. Diabetes
PD SEP
PY 2016
VL 8
IS 5
BP 629
EP 639
DI 10.1111/1753-0407.12341
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA DW1GH
UT WOS:000383390500006
PM 26345135
DA 2025-06-11
ER

PT J
AU Nseir, W
   Taha, H
   Khateeb, J
   Grosovski, M
   Assy, N
AF Nseir, William
   Taha, Hussein
   Khateeb, Julnar
   Grosovski, Maria
   Assy, Nimer
TI Fatty Liver Is Associated with Recurrent Bacterial Infections
   Independent of Metabolic Syndrome
SO DIGESTIVE DISEASES AND SCIENCES
LA English
DT Article
DE Fatty liver; Recurrent bacterial infections; Vitamin D; Metabolic
   syndrome
ID KILLER T-CELLS; VITAMIN-D; NONALCOHOLIC STEATOHEPATITIS; ADIPOSE-TISSUE;
   HEPATIC STEATOSIS; TRACT-INFECTION; INNATE IMMUNITY; URINARY-TRACT;
   UNITED-STATES; KUPFFER CELL
AB Background Diabetes mellitus and obesity are important components of metabolic syndrome (MetS) which are associated with infections. MetS is frequent in nonalcoholic fatty liver disease (NAFLD).
   Aims The objective of this study was to examine whether patients with NAFLD are at higher risk of recurrent bacterial infections (RBIs).
   Methods Two-hundred and forty-seven from 296 hospitalized NAFLD patients were assessed over a three-year period for the occurrence of RBIs and were compared with 100 age and gender-matched patients without NAFLD, who were hospitalized over the same period because of a bacterial infection. An RBI was defined as: a parts per thousand yen2 episodes of bacterial infections per year for a period of three consecutive years. NAFLD was diagnosed by ultrasonography. Biomarkers of inflammation, the level of oxidative stress, insulin resistance, and serum vitamin D levels were measured.
   Results NAFLD patients had significantly more RBIs than the patients without NAFLD (22% vs. 8%; P < 0.001). Univariate analysis showed that age, BMI, male waist circumference, serum 25(OH)D, triglycerides, serum malondialdehyde, and paraoxonase-1 are associated with RBIs in NAFLD patients. Multivariate analysis showed that NAFLD (odds ratio (OR) = 3.0, 95% confidence interval (CI) = 2.6-4.2, P < 0.001), serum 25(OH)D level < 20 ng/mL (OR = 2.6; 95% CI 2.4-3.1, P = 0.01), obesity (BMI > 30 kg/m(2) (OR = 2.2, 95% CI 1.8-2.9, P = 0.02) were associated with RBIs, irrespective of MetS.
   Conclusions NAFLD is associated with increased risk of RBIs irrespective of MetS. Vitamin D insufficiency is frequent in NAFLD and is associated with increased risk of RBIs.
C1 [Nseir, William; Taha, Hussein; Khateeb, Julnar] Holy Family Hosp, Dept Internal Med, IL-16100 Nazareth, Israel.
   [Nseir, William; Khateeb, Julnar] Holy Family Hosp, Infect Unit, IL-16100 Nazareth, Israel.
   [Grosovski, Maria] Ort Braud Coll, Dept Biotechnol, Karmiel, Israel.
   [Assy, Nimer] Ziv Med Ctr, Liver Unit, Safed, Israel.
   [Assy, Nimer] Technion Israel Inst Technol, Fac Med, Haifa, Israel.
C3 Braude Academic College of Engineering; Ziv Medical Center; Technion
   Israel Institute of Technology; Rappaport Faculty of Medicine
RP Nseir, W (corresponding author), Holy Family Hosp, Dept Internal Med, POB 8, IL-16100 Nazareth, Israel.
EM w.nseir@yahoo.com
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NR 47
TC 45
Z9 46
U1 0
U2 8
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0163-2116
EI 1573-2568
J9 DIGEST DIS SCI
JI Dig. Dis. Sci.
PD NOV
PY 2011
VL 56
IS 11
BP 3328
EP 3334
DI 10.1007/s10620-011-1736-5
PG 7
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 843AE
UT WOS:000296643400031
PM 21562784
DA 2025-06-11
ER

PT J
AU Scheffer, PG
   Tushuizen, ME
   Vermue, HPA
   Schindhelm, RK
   Rustemeijer, C
   Diamant, M
AF Scheffer, P. G.
   Tushuizen, M. E.
   Vermue, H. P. A.
   Schindhelm, R. K.
   Rustemeijer, C.
   Diamant, M.
TI Effect of three consecutive meals on the physicochemical properties of
   HDL and LDL in individuals with the metabolic syndrome and patients with
   type 2 diabetes
SO EUROPEAN JOURNAL OF CLINICAL NUTRITION
LA English
DT Article
DE atherogenesis; diabetes; HDL; LDL; metabolic syndrome; postprandial
ID LIPOPROTEIN PARTICLE-SIZE; HIGH-DENSITY-LIPOPROTEINS; NONFASTING
   TRIGLYCERIDES; ENDOTHELIAL DYSFUNCTION; CARDIOVASCULAR EVENTS;
   MYOCARDIAL-INFARCTION; OXIDATIVE STRESS; OXIDIZED LDL;
   HYPERTRIGLYCERIDEMIA; WOMEN
AB Background/Objectives: Postprandial hyperlipidemia, which is exaggerated and prolonged in insulin-resistant individuals, has been associated with cardiovascular disease. The objective of this study was to investigate whether and how the composition, size and function of high-density lipoprotein (HDL) and low-density lipoprotein (LDL) particles are affected in the postprandial state among males with the metabolic syndrome (MetS) or type 2 diabetes (T2DM), compared with controls.
   Subjects/Methods: A total of 14 males with T2DM, 14 with the MetS and 14 age-matched controls were given three standardized high-fat mixed meals (900 kcal; 50-g fat, 75-g carbohydrate and 35-g protein) as breakfast, lunch and dinner. Blood sampling was performed just before each meal, and 4 and 8 h after the last meal. HDL and LDL were isolated by ultracentrifugation and analyzed for their composition, particle diameter and functional properties.
   Results: Postprandial triglycerides levels in plasma, HDL and LDL particles increased significantly in all groups (P<0.01). Compared with the control subjects, patients with T2DM had smaller LDL particles, and in agreement, a lower cholesterol-to-protein content in both fasting and postprandial samples. A prolonged increase in susceptibility of LDL to oxidation was found in all subjects, but was most evident in T2DM. The postprandial effect on LDL oxidation was associated with an increase in LDL triglyceride (r=0.29, P<0.05). In T2DM the anti-oxidative capacity of HDL trended to impairment after the third meal.
   Conclusions: Postprandial increases in triglycerides, especially in T2DM, are accompanied by pro-atherosclerotic functional changes in HDL and LDL particles. European Journal of Clinical Nutrition (2011) 65, 1242-1249; doi:10.1038/ejcn.2011.114; published online 29 June 2011
C1 [Scheffer, P. G.; Vermue, H. P. A.] Vrije Univ Amsterdam, Med Ctr, Dept Clin Chem, Metab Unit, NL-1007 MB Amsterdam, Netherlands.
   [Tushuizen, M. E.; Schindhelm, R. K.; Diamant, M.] Vrije Univ Amsterdam, Med Ctr, Dept Internal Med, Ctr Diabet, NL-1007 MB Amsterdam, Netherlands.
   [Rustemeijer, C.] Hosp Amstelland, Dept Internal Med, Amstelveen, Netherlands.
C3 Vrije Universiteit Amsterdam; Vrije Universiteit Amsterdam
RP Scheffer, PG (corresponding author), Vrije Univ Amsterdam, Med Ctr, Dept Clin Chem, Metab Unit, De Boelelaan 1117,POB 7057, NL-1007 MB Amsterdam, Netherlands.
EM p.scheffer@vumc.nl
RI Tushuizen, Maarten/C-7305-2008; Schindhelm, Roger/B-3975-2008
OI Schindhelm, Roger/0000-0003-2151-6287
FU Dutch Diabetes Foundation [2000.00.025]
FX This study was supported by a grant from the Dutch Diabetes Foundation
   (Grant number 2000.00.025). McDonald's, the Netherlands, is gratefully
   acknowledged for providing the test meals. We gratefully acknowledge
   Bert Volwater for technical support.
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NR 31
TC 9
Z9 11
U1 0
U2 3
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0954-3007
J9 EUR J CLIN NUTR
JI Eur. J. Clin. Nutr.
PD NOV
PY 2011
VL 65
IS 11
BP 1242
EP 1249
DI 10.1038/ejcn.2011.114
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 843ZR
UT WOS:000296717300007
PM 21712838
OA Bronze
DA 2025-06-11
ER

PT J
AU Nakagawa, N
   Yao, N
   Hirayama, T
   Ishida, M
   Ishida, H
   Wada, A
   Fujino, T
   Saijo, Y
   Kikuchi, K
   Hasebe, N
AF Nakagawa, Naoki
   Yao, Naoyuki
   Hirayama, Tomoya
   Ishida, Mari
   Ishida, Hironori
   Wada, Atsushi
   Fujino, Takayuki
   Saijo, Yasuaki
   Kikuchi, Kenjiro
   Hasebe, Naoyuki
TI Potential impact of renin-angiotensin system inhibitors and calcium
   channel blockers on plasma high-molecular-weight adiponectin levels in
   hemodialysis patients
SO HYPERTENSION RESEARCH
LA English
DT Article
DE calcium channel blockers; hemodialysis patients; high-molecular-weight
   adiponectin; renin-angiotensin system inhibitors; visceral obesity
ID CORONARY-ARTERY-DISEASE; VISCERAL FAT ACCUMULATION; CHRONIC
   KIDNEY-DISEASE; STAGE RENAL-DISEASE; METABOLIC SYNDROME;
   CARDIOVASCULAR-DISEASE; DIALYSIS PATIENTS; OXIDATIVE STRESS;
   ADIPOSE-TISSUE; ABDOMINAL FAT
AB Although metabolic syndrome confers an increased risk of cardiovascular disease in the general population, little is known about the alteration of abdominal adiposity and its association with adipocytokines in hemodialysis patients. We investigated the plasma high-molecular-weight (HMW) adiponectin level and its relationship to visceral fat area (VFA) and various markers of atherosclerosis in hemodialysis patients. In a cross-sectional study, conventional cardiovascular risk factors, plasma total and HMW adiponectin, the number of components of the metabolic syndrome and, using computed tomography, the distribution of abdominal adiposity were assessed in 144 hemodialysis patients (90 men and 54 women; mean age, 60.7 years) and 30 age-and sex-matched patients with chronic kidney disease (CKD). Plasma HMW adiponectin levels in hemodialysis patients were significantly higher than those in patients with CKD, negatively associated with VFA and serum triglycerides and positively associated with plasma total adiponectin, as well as the HMW-to-total adiponectin ratio in men and women (all P<0.05) in a simple regression analysis. In a multiple regression analysis, VFA was a significant determinant of HMW adiponectin in hemodialysis patients. Furthermore, after adjustment for classical risk factors, HMW adiponectin levels were significantly higher in patients undergoing treatment with renin-angiotensin system inhibitors or calcium channel blockers compared with patients not undergoing such treatment. This study shows that plasma HMW adiponectin levels were negatively associated with VFA and positively associated with treatment with blockade of the renin-angiotensin system and of the calcium channel. Therefore, these drugs might be effective for improving adipocytokine-related metabolic abnormalities in hemodialysis patients. Hypertension Research (2011) 34, 592-598; doi:10.1038/hr.2010.282; published online 3 February 2011
C1 [Nakagawa, Naoki; Fujino, Takayuki; Kikuchi, Kenjiro; Hasebe, Naoyuki] Asahikawa Med Univ, Dept Internal Med, Div Cardiol Nephrol Pulmonol & Neurol, Asahikawa, Hokkaido 0788510, Japan.
   [Yao, Naoyuki; Hirayama, Tomoya; Ishida, Mari; Ishida, Hironori] Kitasaito Hosp, Dept Nephrol, Asahikawa, Hokkaido, Japan.
   [Yao, Naoyuki; Hirayama, Tomoya; Ishida, Mari; Ishida, Hironori] Kitasaito Hosp, Dept Urol, Asahikawa, Hokkaido, Japan.
   [Wada, Atsushi] Asahikawa Red Cross Hosp, Dept Nephrol, Asahikawa, Hokkaido, Japan.
   [Saijo, Yasuaki] Asahikawa Med Univ, Dept Hlth Sci, Asahikawa, Hokkaido 0788510, Japan.
C3 Asahikawa Medical College; Asahikawa Medical College
RP Nakagawa, N (corresponding author), Asahikawa Med Univ, Dept Internal Med, Div Cardiol Nephrol Pulmonol & Neurol, Asahikawa, Hokkaido 0788510, Japan.
EM naka-nao@asahikawa-med.ac.jp
RI Ishida, Mari/I-5899-2019; Saijo, Yasuaki/J-3796-2019
OI Nakagawa, Naoki/0000-0002-5398-3667; Saijo, Yasuaki/0000-0002-6211-8202
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NR 34
TC 13
Z9 13
U1 0
U2 1
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0916-9636
J9 HYPERTENS RES
JI Hypertens. Res.
PD MAY
PY 2011
VL 34
IS 5
BP 592
EP 598
DI 10.1038/hr.2010.282
PG 7
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 759MQ
UT WOS:000290250200010
PM 21289628
OA Bronze, Green Submitted
DA 2025-06-11
ER

PT J
AU Raman, SV
   Phatak, K
   Hoyle, JC
   Pennell, ML
   McCarthy, B
   Tran, T
   Prior, TW
   Olesik, JW
   Lutton, A
   Rankin, C
   Kissel, JT
   al-Dahhak, R
AF Raman, Subha V.
   Phatak, Kavita
   Hoyle, J. Chad
   Pennell, Michael L.
   McCarthy, Beth
   Tran, Tam
   Prior, Thomas W.
   Olesik, John W.
   Lutton, Anthony
   Rankin, Chelsea
   Kissel, John T.
   al-Dahhak, Roula
TI Impaired myocardial perfusion reserve and fibrosis in Friedreich ataxia:
   a mitochondrial cardiomyopathy with metabolic syndrome
SO EUROPEAN HEART JOURNAL
LA English
DT Article
DE Cardiomyopathy; Microcirculation; Magnetic resonance imaging; Metabolic
   syndrome
ID IDEBENONE; HEART; PROGRESSION; CARDIOLOGY; DIAGNOSIS; DISEASE; ADULTS
AB Aims Cardiomyopathy produces significant mortality in patients with Friedreich ataxia ( FA), a genetic disorder that produces intra-mitochondrial iron accumulation. We sought to test the hypothesis that abnormal myocardial perfusion reserve and fibrosis represent early manifestations of cardiomyopathy.
   Methods and results Twenty-six patients with genetically proven FA ages 36 +/- 12 years without cardiomyopathy and eight controls underwent cardiac magnetic resonance with adenosine. Precontrast imaging for myocardial iron estimation was performed. Myocardial perfusion reserve index (MPRI) was quantified using the normalized upslope of myocardial enhancement during vasodilator stress vs. rest. Left ventricular (LV) mass and volumes were computed from short-axis cine images. Serologies included lipids, and platelets were isolated for iron quantification using inductively coupled plasma mass spectrometry. Left ventricular ejection fraction and mass averaged 64.1 +/- 8.3% and 62.7 +/- 16.7 g/m(2), respectively, indicating preserved systolic function and absence of significant hypertrophy. Myocardial perfusion reserve index quantification revealed significantly lower endocardial-to-epicardial perfusion reserve in patients vs. controls (0.80 +/- 0.18 vs. 1.22 +/- 0.36, P = 0.01). Lower MPRI was predicted by increased number of metabolic syndrome (met-S) features (P < 0.01). Worse concentric remodelling occurred with increased GAA repeat length (r = 0.64, P < 0.001). Peripheral platelet iron measurement showed no distinction between patients and controls (5.4 +/- 8.5 x 10(-7) vs. 5.5 +/- 2.9 x 10(-7) ng/platelet, P = 0.88), nor did myocardial T2* measures.
   Conclusions Patients with FA have abnormal myocardial perfusion reserve that parallels met-S severity. Impaired perfusion reserve and fibrosis occur in the absence of significant hypertrophy and prior to clinical heart failure, providing potential therapeutic targets for stage B cardiomyopathy in FA and related myocardial diseases.
C1 [Raman, Subha V.; Phatak, Kavita; Hoyle, J. Chad; Pennell, Michael L.; McCarthy, Beth; Tran, Tam; Prior, Thomas W.; Olesik, John W.; Lutton, Anthony; Kissel, John T.] Ohio State Univ, Columbus, OH 43210 USA.
   [Rankin, Chelsea; al-Dahhak, Roula] Nationwide Childrens Hosp, Columbus, OH USA.
C3 University System of Ohio; Ohio State University; University System of
   Ohio; Ohio State University; Nationwide Childrens Hospital
RP Raman, SV (corresponding author), Ohio State Univ, 473 W 12th Ave,Suite 200, Columbus, OH 43210 USA.
EM raman.1@osu.edu
RI Hoyle, Joseph/E-3269-2011; Raman, Subha/E-3918-2011; Tran,
   Tam/JJF-1520-2023; Pennell, Michael/IXD-3076-2023
OI Lutton, Anthony/0000-0002-5268-8308
FU Ride Ataxia II; Friedreich's Ataxia Research Alliance (FARA); National
   Ataxia Foundation; Siemens
FX This work was supported by a Kyle Bryant Translational Research Award
   jointly funded by Ride Ataxia II, the Friedreich's Ataxia Research
   Alliance (FARA), and the National Ataxia Foundation. Statistical support
   was provided via UL1RR025755.S. V. R. receives research support from
   Siemens.
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NR 37
TC 69
Z9 71
U1 0
U2 5
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0195-668X
EI 1522-9645
J9 EUR HEART J
JI Eur. Heart J.
PD MAR
PY 2011
VL 32
IS 5
BP 561
EP 567
DI 10.1093/eurheartj/ehq443
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 730JC
UT WOS:000288028600013
PM 21156720
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Zhang, T
   Ni, M
   Jia, J
   Deng, YJ
   Sun, XY
   Wang, XQ
   Chen, YT
   Fang, LL
   Zhao, H
   Xu, SS
   Ma, YB
   Zhu, JS
   Pan, FM
AF Zhang, Tao
   Ni, Man
   Jia, Juan
   Deng, Yujie
   Sun, Xiaoya
   Wang, Xinqi
   Chen, Yuting
   Fang, Lanlan
   Zhao, Hui
   Xu, Shanshan
   Ma, Yubo
   Zhu, Jiansheng
   Pan, Faming
TI Research on the relationship between common metabolic syndrome and
   meteorological factors in Wuhu, a subtropical humid city of China
SO BMC PUBLIC HEALTH
LA English
DT Article
DE Metabolic syndrome; Climate variation; Short-term exposure effect
ID DIURNAL TEMPERATURE-RANGE; OUTDOOR TEMPERATURE; ADIPOSE-TISSUE;
   MORTALITY; RISK; ASSOCIATION; INCREASE; DISEASE; STRESS; STROKE
AB As climate conditions deteriorate, human health faces a broader range of threats. This study aimed to determine the risk of death from metabolic syndrome (MetS) due to meteorological factors. We collected daily data from 2014 to 2020 in Wuhu City, including meteorological factors, environmental pollutants and death data of common MetS (hypertension, hyperlipidemia and diabetes), as well as a total number of 15,272 MetS deaths. To examine the relationship between meteorological factors, air pollutants, and MetS mortality, we used a generalized additive model (GAM) combined with a distributed delay nonlinear model (DLNM) for time series analysis. The relationship between the above factors and death outcomes was preliminarily evaluated using Spearman analysis and structural equation modeling (SEM). As per out discovery, diurnal temperature range (DTR) and daily mean temperature (T mean) increased the MetS mortality risk notably. The ultra low DTR raised the MetS mortality risk upon the general people, with the highest RR value of 1.033 (95% CI: 1.002, 1.065) at lag day 14. In addition, T mean was also significantly associated with MetS death. The highest risk of ultra low and ultra high T mean occured on the same day (lag 14), RR values were 1.043 (95% CI: 1.010, 1.077) and 1.032 (95% CI: 1.003, 1.061) respectively. Stratified analysis's result showed lower DTR had a more pronounced effect on women and the elderly, and ultra low and high T mean was a risk factor for MetS mortality in women and men. The elderly need to take extra note of temperature changes, and different levels of T mean will increase the risk of death. In warm seasons, ultra high RH and T mean can increase the mortality rate of MetS patients.
C1 [Zhang, Tao; Ni, Man; Jia, Juan; Deng, Yujie; Sun, Xiaoya; Wang, Xinqi; Chen, Yuting; Fang, Lanlan; Zhao, Hui; Xu, Shanshan; Ma, Yubo; Pan, Faming] Anhui Med Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, 81 Meishan Rd, Hefei 230032, Anhui, Peoples R China.
   [Zhang, Tao; Ni, Man; Jia, Juan; Chen, Yuting; Fang, Lanlan; Xu, Shanshan; Ma, Yubo; Pan, Faming] Anhui Med Univ, Key Lab Major Autoimmune Dis, 81 Meishan Rd, Hefei 230032, Anhui, Peoples R China.
   [Deng, Yujie; Sun, Xiaoya; Wang, Xinqi; Zhao, Hui] Anhui Med Univ, Dept Hosp Management Res, Affiliated Hosp 1, Hefei 230032, Anhui, Peoples R China.
   [Zhu, Jiansheng] Wuhu Ctr Dis Control & Prevent, Wuhu, Anhui, Peoples R China.
   [Pan, Faming] Anhui Med Univ, 81 Meishan Rd, Hefei 230032, Anhui, Peoples R China.
C3 Anhui Medical University; Anhui Medical University; Anhui Medical
   University; Anhui Medical University
RP Pan, FM (corresponding author), Anhui Med Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, 81 Meishan Rd, Hefei 230032, Anhui, Peoples R China.; Pan, FM (corresponding author), Anhui Med Univ, Key Lab Major Autoimmune Dis, 81 Meishan Rd, Hefei 230032, Anhui, Peoples R China.; Pan, FM (corresponding author), Anhui Med Univ, 81 Meishan Rd, Hefei 230032, Anhui, Peoples R China.
EM famingpan@ahmu.edu.cn
RI zhang, tao/KWU-2129-2024; DENG, Yujie/K-1745-2019
FU National Natural Science Foundation of China
FX The authors thank the participants who made this study possible and
   gratefully acknowledge the role of the staff and volunteers in
   collecting the data.
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NR 56
TC 2
Z9 2
U1 2
U2 7
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2458
J9 BMC PUBLIC HEALTH
JI BMC Public Health
PD NOV 29
PY 2023
VL 23
IS 1
AR 2363
DI 10.1186/s12889-023-17299-8
PG 15
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA CE6S8
UT WOS:001123617800010
PM 38031031
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Huang, CH
   Chen, LF
   Li, JT
   Ma, JJ
   Luo, J
   Lv, Q
   Xiao, J
   Gao, P
   Chai, W
   Li, X
   Zhang, M
   Hu, FL
   Hu, DS
   Qin, P
AF Huang, Cuihong
   Chen, Lifang
   Li, Jiangtao
   Ma, Juanjuan
   Luo, Jun
   Lv, Qian
   Xiao, Jian
   Gao, Pan
   Chai, Wen
   Li, Xu
   Zhang, Ming
   Hu, Fulan
   Hu, Dongsheng
   Qin, Pei
TI Mitochondrial DNA Copy Number and Risk of Diabetes Mellitus and
   Metabolic Syndrome
SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Review
DE mitochondrial DNA; diabetes mellitus; metabolic syndrome; systematic
   review; meta-analysis
ID PERIPHERAL-BLOOD; OXIDATIVE STRESS; CARDIOVASCULAR-DISEASE; ASSOCIATION;
   METAANALYSIS; MORTALITY; OBESITY
AB Context Mitochondrial DNA (mtDNA) plays a key role in diabetes mellitus and metabolic syndrome (MetS). An increasing number of studies have reported the association between mtDNA copy number (mtDNA-CN) and the risk of diabetes mellitus and MetS; however, the associations remain conflicted and a systematic review and meta-analysis on the association between mtDNA-CN and diabetes mellitus and MetS is lacking. Objective We aimed to investigate the association of mtDNA-CN and diabetes mellitus and MetS using a systematic review and meta-analysis of observational studies. Methods PubMed, EMBASE, and Web of Science were searched up to December 15, 2022. Random-effect models were used to summarize the relative risks (RRs) and 95% CIs. Results A total of 19 articles were included in the systematic review and 6 articles (12 studies) in the meta-analysis involving 21 714 patients with diabetes (318 870 participants) and 5031 MetS (15 040 participants). Compared to the highest mtDNA-CN, the summary RR (95% CIs) for the lowest mtDNA-CN were 1.06 (95% CI, 1.01-1.12; I-2 = 79.4%; n = 8) for diabetes (prospective study: 1.11 (1.02-1.21); I-2 = 22.6%; n = 4; case-control: 1.27 (0.66-2.43); I-2 = 81.8%; n = 2; cross-sectional: 1.01 (0.99-1.03); I-2 = 74.7%; n = 2), and 1.03 (0.99-1.07; I-2 = 70.6%; n = 4) for MetS (prospective: 2.87 (1.51-5.48); I-2 = 0; n = 2; cross-sectional: 1.02 (1.01-1.04); I-2 = 0; n = 2). Conclusion Decreased mtDNA-CN was associated with increased risk of diabetes mellitus and MetS when limited to prospective studies. More longitudinal studies are warranted.
C1 [Huang, Cuihong; Ma, Juanjuan; Qin, Pei] Shenzhen Qianhai Shekou Free Trade Zone Hosp, Ctr Clin Epidemiol & Evidence Based Med, Shenzhen 518000, Guangdong, Peoples R China.
   [Huang, Cuihong] Sun Yat Sen Univ, Sch Publ Hlth, Guangzhou 510080, Guangdong, Peoples R China.
   [Chen, Lifang; Li, Jiangtao; Luo, Jun; Lv, Qian; Xiao, Jian] Shenzhen Qianhai Shekou Free Trade Zone Hosp, Dept Cardiovasc Med, Shenzhen 518000, Guangdong, Peoples R China.
   [Gao, Pan; Chai, Wen] Shenzhen Univ Gen Hosp, Dept Neurol, Shenzhen 518000, Guangdong, Peoples R China.
   [Li, Xu] Shenzhen Univ, Dept Neurosurg, Affiliated Hosp 2, Shenzhen 518000, Guangdong, Peoples R China.
   [Zhang, Ming; Hu, Fulan; Hu, Dongsheng] Shenzhen Univ, Sch Publ Hlth, Dept Biostat & Epidemiol, Hlth Sci Ctr, Shenzhen 518000, Guangdong, Peoples R China.
   [Qin, Pei] Shenzhen Qianhai Shekou Free Trade Zone Hosp, Gongye 7th Rd, Shenzhen 518000, Guangdong, Peoples R China.
C3 Shenzhen Qianhai Shekou Free Trade Zone Hospital; Sun Yat Sen
   University; Shenzhen Qianhai Shekou Free Trade Zone Hospital; Shenzhen
   University; Shenzhen University; Shenzhen Qianhai Shekou Free Trade Zone
   Hospital
RP Qin, P (corresponding author), Shenzhen Qianhai Shekou Free Trade Zone Hosp, Gongye 7th Rd, Shenzhen 518000, Guangdong, Peoples R China.
EM qinpei225@163.com
RI Ma, Juan/KPB-2288-2024; ming, zhang/ABH-2736-2020
OI Qin, Pei/0000-0003-2303-0379; Hu, Fulan/0000-0002-2386-1503
FU National Natural Science Foundation of China [82103940]; Natural Science
   Foundation of Guangdong Province [2022A1515010503]; Nanshan District
   Science and Technology Program Key Project [NS2022009]
FX This work was supported by the National Natural Science Foundation of
   China (grant No. 82103940), the Natural Science Foundation of Guangdong
   Province (grant No. 2022A1515010503), and the Nanshan District Science
   and Technology Program Key Project (grant No. NS2022009)
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NR 57
TC 3
Z9 3
U1 3
U2 9
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0021-972X
EI 1945-7197
J9 J CLIN ENDOCR METAB
JI J. Clin. Endocrinol. Metab.
PD JAN
PY 2024
VL 109
IS 1
BP E406
EP E417
DI 10.1210/clinem/dgad403
EA JUL 2023
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA CZ9B7
UT WOS:001051199200001
PM 37431585
DA 2025-06-11
ER

PT J
AU Ding, J
   Liu, Q
   Liu, Z
   Guo, HB
   Liang, JY
   Zhang, Y
AF Ding, Jun
   Liu, Qi
   Liu, Ze
   Guo, Hongbin
   Liang, Jieyu
   Zhang, Yi
TI Association Between Dietary Zinc Intake and Metabolic Syndrome. A
   Meta-Analysis of Observational Studies
SO FRONTIERS IN NUTRITION
LA English
DT Review
DE dietary zinc intake; metabolic syndrome; meta-analysis; observational
   studies; clinical nutrition
ID 3RD NATIONAL-HEALTH; INSULIN-RESISTANCE; OXIDATIVE STRESS;
   SUPPLEMENTATION; PREVALENCE; ADOLESCENTS; RISK; CONSUMPTION; DISEASE;
   SERUM
AB Background: Epidemiological studies have investigated the association between dietary zinc intake and metabolic syndrome (MetS). However, their results are conflicting. This meta-analysis was therefore employed to investigate the associations further. Methods:A comprehensive literature search was employed by using the electronic database of PubMed, Web of Science, and Embase up to November 2021. The pooled relative risk (RR) of MetS for the highest vs. lowest dietary zinc intake category, and the weighted mean difference (WMD) of dietary zinc intake for MetS vs. control subjects as well as their corresponding 95% confidence interval (CI) were calculated. Results:A total of 13 observational studies (18,073 participants) were identified in this meta-analysis. The overall multi-variable adjusted RR demonstrated that the dietary zinc intake was inversely associated with MetS (RR = 0.75, 95%CI: 0.61 to 0.93; P = 0.009). The subgroup analysis confirmed such findings in cross-sectional (RR = 0.70, 95%CI: 0.55 to 0.87; P = 0.002), NCEP-ATP III (RR = 0.64, 95%CI: 0.48 to 0.84; P = 0.002), adult (RR = 0.77, 95%CI: 0.62 to 0.96; P = 0.02), dietary recall method (RR = 0.70, 95%CI: 0.55 to 0.87; P = 0.002), and > 500 sample-sized study (RR = 0.79, 95%CI: 0.64 to 0.99; P = 0.002), respectively. On the other hand, the overall combined WMD showed that the dietary zinc intake in MetS was also lower than that in control subjects (WMD = -0.21, 95%CI: -0.42 to 0.00; P = 0.05). Conclusions: Our results suggest that the dietary zinc intake is negatively associated with MetS. However, due to the limitation of available evidence. More well-designed prospective cohort studies are still needed.
C1 [Ding, Jun] Changsha Social Work Coll, Changsha, Peoples R China.
   [Liu, Qi; Liu, Ze; Guo, Hongbin; Liang, Jieyu; Zhang, Yi] Cent South Univ, Xiangya Hosp, Dept Orthopaed, Changsha, Peoples R China.
   [Liu, Qi; Liu, Ze; Guo, Hongbin; Liang, Jieyu; Zhang, Yi] Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha, Peoples R China.
C3 Changsha Social Work College; Central South University; Central South
   University
RP Zhang, Y (corresponding author), Cent South Univ, Xiangya Hosp, Dept Orthopaed, Changsha, Peoples R China.; Zhang, Y (corresponding author), Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha, Peoples R China.
EM zhangyi0205@csu.edu.cn
RI Zhang, Yi/U-8628-2017; Ding, Jun/ABH-1012-2021; 梁, 捷予/GQH-8556-2022;
   Guo, Hongbin/ABA-7900-2021
FU National Natural Science Foundation of China [82102581]; National
   Postdoctoral Science Foundation of China [2021M693562]; Provincial
   Outstanding Postdoctoral Innovative Talents Program of Hunan
   [2021RC2020]; Provincial Natural Science Foundation of Hunan
   [2019JJ40517]; Young Investigator Grant of Xiangya Hospital, Central
   South University [2020Q14]; FuQing Postdoc Program of Xiangya Hospital,
   Central South University [176]
FX Funding This study was supported by National Natural Science Foundation
   of China (82102581), National Postdoctoral Science Foundation of China
   (2021M693562), Provincial Outstanding Postdoctoral Innovative Talents
   Program of Hunan (2021RC2020), Provincial Natural Science Foundation of
   Hunan (2019JJ40517), Young Investigator Grant of Xiangya Hospital,
   Central South University (2020Q14), and FuQing Postdoc Program of
   Xiangya Hospital, Central South University (176).
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NR 55
TC 5
Z9 5
U1 0
U2 8
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD FEB 3
PY 2022
VL 9
AR 825913
DI 10.3389/fnut.2022.825913
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA ZH3QJ
UT WOS:000760856600001
PM 35187040
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Gao, YH
   Zhao, CW
   Liu, B
   Dong, N
   Ding, L
   Li, YR
   Liu, JG
   Feng, W
   Qi, X
   Jin, XH
AF Gao, Yu-Hang
   Zhao, Cheng-Wu
   Liu, Bo
   Dong, Ning
   Ding, Lu
   Li, Ye-Ran
   Liu, Jian-Guo
   Feng, Wei
   Qi, Xin
   Jin, Xian-Hua
TI An update on the association between metabolic syndrome and
   osteoarthritis and on the potential role of leptin in osteoarthritis
SO CYTOKINE
LA English
DT Review
DE Metabolic syndrome; Osteoarthritis; Epidemiology; Leptin;
   Pathophysiology
ID INFRAPATELLAR FAT PAD; DIET-INDUCED OBESITY; KNEE OSTEOARTHRITIS;
   SYNOVIAL-FLUID; ADIPOSE-TISSUE; ARTICULAR CHONDROCYTES; PHYSICAL
   FUNCTION; ADIPOKINE LEVELS; OLDER-ADULTS; WEIGHT-LOSS
AB Metabolic syndrome (MetS) has been associated with osteoarthritis (OA). Leptin, which is one of the markers of MetS, has been associated with OA pathophysiology. This study aimed to provide an update on the association between MetS and OA and on the potential role of leptin in OA. In this review, we summarized the current knowledge of the association between MetS and OA and updated the evidence on the potential role of leptin in OA. Clinical studies have investigated the epidemiologic association between MetS or its components and OA. Results suggested strong epidemiologic associations between MetS and OA, especially in the Asian population. Animal studies also indicated that metabolic dysregulation may lead to OA pathogenesis. The systemic role of MetS in OA pathophysiology is associated with obesity-related inflammation, the beneficial role of n-3 polyunsaturated fatty acids and deleterious role of cholesterol, physical inactivity, hypertension-induced subchondral ischemia, dyslipidemia-induced ectopic lipid deposition in chondrocytes, hyperglycemia-induced local effects of oxidative stress and advanced glycation end-products, low-grade systemic inflammation, and obesity-related adipokines by inducing the expression of proinflammtory factors. Leptin levels in serum/plasma and synovial fluid were associated with joint pain, radiographic progression, bone formation biomarkers, cartilage volume, knee OA incidence, and total joint arthroplasty in OA patients. Elevated leptin expression and increased effect of leptin on infrapatellar fat pad, synovium, articular cartilage, and bone were also involved in the pathogenesis of OA. Current knowledge indicates a convincing epidemiologic association between MetS and OA, especially in the Asian population. Animal studies have also shown that metabolic dysregulation may lead to OA pathogenesis. Accumulating evidence suggests that leptin may play a potential role in OA pathogenesis. Therefore, leptin and its receptor may be an emerging target for intervention in metabolic-associated OA.
C1 [Gao, Yu-Hang; Ding, Lu; Li, Ye-Ran; Liu, Jian-Guo; Feng, Wei; Qi, Xin] First Hosp Jilin Univ, Dept Orthopaed Surg, Changchun 130021, Jilin, Peoples R China.
   [Zhao, Cheng-Wu] First Hosp Jilin Univ, Dept Sports Med, Changchun 130021, Jilin, Peoples R China.
   [Liu, Bo] First Hosp Jilin Univ, Dept Ultrasound, Changchun 130021, Jilin, Peoples R China.
   [Dong, Ning] First Hosp Jilin Univ, Dept Pediat Surg, Changchun 130021, Jilin, Peoples R China.
   [Jin, Xian-Hua] Second Hosp Jilin Univ, Dept Dermatol, Changchun 130022, Jilin, Peoples R China.
C3 Jilin University; Jilin University; Jilin University; Jilin University;
   Jilin University
RP Qi, X (corresponding author), First Hosp Jilin Univ, Dept Orthopaed Surg, Changchun 130021, Jilin, Peoples R China.; Jin, XH (corresponding author), Second Hosp Jilin Univ, Dept Dermatol, Changchun 130022, Jilin, Peoples R China.
EM qixindoc@163.com; jinxianhuadoc@163.com
RI GAO, YUHANG/IAM-2032-2023
OI zhao, chengwu/0000-0002-2576-5574
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NR 131
TC 37
Z9 38
U1 1
U2 23
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 1043-4666
EI 1096-0023
J9 CYTOKINE
JI Cytokine
PD MAY
PY 2020
VL 129
AR 155043
DI 10.1016/j.cyto.2020.155043
PG 10
WC Biochemistry & Molecular Biology; Cell Biology; Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology; Immunology
GA LF9KQ
UT WOS:000527732100002
PM 32078923
DA 2025-06-11
ER

PT J
AU von Bibra, H
   Ströhle, A
   Sutton, MS
   Worm, N
AF von Bibra, Helene
   Stroehle, Alexander
   Sutton, Martin St John
   Worm, Nicolai
TI Dietary therapy in heart failure with preserved ejection fraction and/or
   left ventricular diastolic dysfunction in patients with metabolic
   syndrome
SO INTERNATIONAL JOURNAL OF CARDIOLOGY
LA English
DT Review
DE Carbohydrate restriction; Metabolic syndrome; Heart failure preserved
   ejection fraction; Insulin resistance; Diastolic dysfunction
ID TYPE-2 DIABETES-MELLITUS; RANDOMIZED CONTROLLED-TRIALS; CARDIOVASCULAR
   RISK-FACTORS; LOW-CARBOHYDRATE DIETS; GLYCEMIC LOAD DIET; LOW-FAT DIETS;
   WEIGHT-LOSS; INSULIN-RESISTANCE; OXIDATIVE STRESS; CLINICAL-TRIALS
AB Background: Heart failure is an ongoing epidemic of left ventricular (LV) dilatation and/or dysfunction due to the increasing prevalence of predisposing risk factors such as age, physical inactivity, (abdominal) obesity, and type-2-diabetes. Approximately half of these patients have diastolic heart failure (HFpEF). The prognosis of HFpEF is comparable to that of systolic heart failure, but without any known effective treatment.
   Diastolic dysfunction: A biomathematically corrected diagnostic approach is presented that quantifies diastolic dysfunction via the predominant age dependency of LV diastolic function and unmasks (metabolic) risk factors, that are independent of age and, therefore, potential targets for therapy. Patients with HFpEF have reduced cardiac energy reserve that is frequently caused by insulin resistance. Consequently, HFpEF and/or LV diastolic dysfunction may be regarded as a cardiac manifestation of the metabolic syndrome (MetS).
   Dietary therapy: Accordingly, a causal therapy for metabolically induced dysfunction aims at normalizing insulin sensitivity by improving postprandial glucose and lipid metabolism. The respective treatments include 1) weight loss induced by dietary energy restriction that is often not sustained long-term and 2) independent of weight loss, focus on carbohydrate modification in exchange for an increase in protein and fat, ideally combined with an aerobic exercise program. Hence, beneficial effects of different macronutrient compositions in the dietary therapy of the underlying MetS are discussed together with the most recently available publications and meta-analyses.
   Conclusion: Modulation/restriction of carbohydrate intake normalizes postprandial hyperglycemic and insulinemic peaks and has been shown to improve all manifestations of the MetS and also to reduce cardiovascular risk. (C) 2017 Elsevier B.V. All rights reserved.
C1 [von Bibra, Helene] Acad Teaching Hosp Muenchen Bogenhausen, Clin Endocrinol Diabet & Vasc Med, Munich, Germany.
   [Stroehle, Alexander] Leibniz Univ Hannover, Nutr Physiol & Human Nutr Unit, Inst Food Sci & Human Nutr, Hannover, Germany.
   [Sutton, Martin St John] Univ Penn, Dept Med, Cardiovascular Div, Philadelphia, PA 19104 USA.
   [Worm, Nicolai] Univ Hlth Care Management & Prevent, Dept Nutr, Saarbrucken, Germany.
C3 Munchen Klinik; Leibniz University Hannover; University of Pennsylvania
RP von Bibra, H (corresponding author), Stadt Klinikum Munchen GmbH, Klinikum Bogenhausen, Munich, Germany.
EM vonbibra@gmx.de
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NR 83
TC 18
Z9 18
U1 0
U2 20
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0167-5273
EI 1874-1754
J9 INT J CARDIOL
JI Int. J. Cardiol.
PD MAY 1
PY 2017
VL 234
BP 7
EP 15
DI 10.1016/j.ijcard.2017.01.003
PG 9
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA EW4LU
UT WOS:000402473800002
PM 28209386
DA 2025-06-11
ER

PT J
AU Gharipour, M
   Sadeghi, M
   Salehi, M
   Behmanesh, M
   Khosravi, E
   Dianatkhah, M
   Javanmard, SH
   Razavi, R
   Gharipour, A
AF Gharipour, Mojgan
   Sadeghi, Masoumeh
   Salehi, Mansour
   Behmanesh, Mehrdad
   Khosravi, Elham
   Dianatkhah, Minoo
   Javanmard, Shaghayegh Haghjoo
   Razavi, Rouzbeh
   Gharipour, Amin
TI Association of expression of selenoprotein P in mRNA and protein levels
   with metabolic syndrome in subjects with cardiovascular disease: Results
   of the Selenegene study
SO JOURNAL OF GENE MEDICINE
LA English
DT Article
DE cardiovascular disease; expression; metabolic syndrome; mRNA protein;
   Selenegene study; selenoprotein P
ID PREVENTION TRIAL SELECT; ANTIOXIDANT VITAMINS; INSULIN-RESISTANCE;
   PROSTATE-CANCER; SELENIUM STATUS; SERUM SELENIUM; PLASMA;
   SUPPLEMENTATION; SU.VI.MAX; MINERALS
AB Background Selenoprotein P (SeP) is involved in transporting selenium from the liver to target tissues. Because SeP confers protection against disease by reducing chronic oxidative stress, the present study aimed to assess the level of SeP in the serum of patients with metabolic syndrome (MetS) with a history of cardiovascular disease (CVD).
   Methods A cross-sectional study was conducted in 63 and 71 subjects with and without MetS in the presence of documented CVD. All demographic, anthropometric and cardiometabolic variables (lipids, blood glucose, blood pressure) were assessed. Lifestyle-related factors and personal history and familial CVD risk factors were recorded. The expression of SELP in mRNA and protein levels in the serumwasmeasured, andMetSwas determined usingATPIII criteria. Binary logistic regression analysis demonstrated MetS and SeP to be dependent and independent variables, respectively.
   Results Mean of systolic and diastolic blood pressure, triglyceride, high-density lipoproteincholesterol, fasting blood sugar, body mass index and waist circumference were higher among subjects with MetS (p = 0.05). The mean of selenium was higher among subjects with MetS, whereas the mean of SeP was lower among subjects with MetS (p < 0.001). In the unadjusted model, the SeP had decreased odds for MetS [odds ratio (OR) = 0.995; 95% confidence interval (CI) = 0.989-1.00] (p < 0.04). Furthermore, the association between MetS and SeP levels remained marginally significant even after adjusting for potential confounders such as age, gender, family history, smoking status and nutrition. SeP and waist circumference show a significant relationship (OR = 0.995; 95% CI = 0.990-1.00) (p < 0.033).
   Conclusions We have demonstrated a significant decrease in circulating SeP levels according to MetS status in patients with documented cardiovascular disease.
C1 [Gharipour, Mojgan; Khosravi, Elham] Isfahan Univ Med Sci, Isfahan Cardiovasc Res Ctr, Cardiovasc Res Inst, Esfahan, Iran.
   [Sadeghi, Masoumeh; Dianatkhah, Minoo] Isfahan Univ Med Sci, Cardiac Rehabil Res Ctr, Isfahan Cardiovasc Res Inst, Esfahan, Iran.
   [Salehi, Mansour] Tarbiat Modares Univ, Fac Biol Sci, Dept Genet, Tehran, Iran.
   [Behmanesh, Mehrdad] Isfahan Univ Med Sci, Dept Genet, Esfahan, Iran.
   [Behmanesh, Mehrdad] Isfahan Univ Med Sci, Mol Biol Med Sch, Esfahan, Iran.
   [Javanmard, Shaghayegh Haghjoo] Isfahan Univ Med Sci, Appl Physiol Res Ctr, Cardiovasc Res Inst, Esfahan, Iran.
   [Razavi, Rouzbeh; Gharipour, Amin] Griffith Univ, Sch Informat & Commun Technol, Nathan Campus, Nathan, Qld, Australia.
C3 Isfahan University of Medical Sciences; Isfahan University of Medical
   Sciences; Tarbiat Modares University; Isfahan University of Medical
   Sciences; Isfahan University of Medical Sciences; Isfahan University of
   Medical Sciences; Griffith University
RP Sadeghi, M (corresponding author), Isfahan Univ Med Sci, Cardiac Rehabil Res Ctr, Cardiovasc Res Inst, Esfahan, Iran.
EM sadeghimasoumeh@gmail.com
RI Gharipour, mojgan/R-3486-2019; Sadeghi, Masoumeh/W-2291-2017; Behmanesh,
   Mehrdad/J-4319-2015; Haghjooy Javanmard, Shaghayegh/W-5060-2017
OI Haghjooy Javanmard, Shaghayegh/0000-0002-3853-5006; Sadeghi Mahonak,
   Masoumeh/0000-0001-7179-5558; Gharipour, Mojgan/0000-0001-7397-1172
FU Isfahan University of Medical Sciences Deputy of Research [192142]
FX Isfahan University of Medical Sciences Deputy of Research, Grant/Award
   Number: 192142
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NR 41
TC 23
Z9 25
U1 1
U2 14
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1099-498X
EI 1521-2254
J9 J GENE MED
JI J. Gene. Med.
PD MAR
PY 2017
VL 19
IS 3
AR e2945
DI 10.1002/jgm.2945
PG 7
WC Biotechnology & Applied Microbiology; Genetics & Heredity; Medicine,
   Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Genetics & Heredity; Research &
   Experimental Medicine
GA EQ6RS
UT WOS:000398211400003
PM 28190280
DA 2025-06-11
ER

PT J
AU Sugiura, M
   Nakamura, M
   Ogawa, K
   Ikoma, Y
   Yano, M
AF Sugiura, Minoru
   Nakamura, Mieko
   Ogawa, Kazunori
   Ikoma, Yoshinori
   Yano, Masamichi
TI High serum carotenoids associated with lower risk for the metabolic
   syndrome and its components among Japanese subjects: Mikkabi cohort
   study
SO BRITISH JOURNAL OF NUTRITION
LA English
DT Article
DE Antioxidants; Carotenoids; Metabolic syndrome; Longitudinal studies;
   Cohort studies
ID CORONARY-HEART-DISEASE; 3RD NATIONAL-HEALTH; OXIDATIVE STRESS;
   YOUNG-ADULTS; INSULIN-RESISTANCE; DIETARY PATTERNS; ANTIOXIDANT
   SUPPLEMENTATION; LOWER PREVALENCE; FREE-RADICALS; VITAMIN-C
AB Recent epidemiological studies show the association of carotenoids with the metabolic syndrome (MetS), but thorough longitudinal cohort studies regarding this association have not been well conducted. The objective of this study was to investigate longitudinally whether serum carotenoids are associated with the risk of developing the MetS and its components in Japanese subjects. We conducted a follow-up study on 1073 men and women aged 30-79 years at the baseline from the Mikkabi prospective cohort study. Those who participated in the baseline and completed follow-up surveys were examined longitudinally. Over the 10-year period, 910 subjects (295 men and 615 women) took part in the follow-up survey at least once. Over a mean follow-up period of 7.8 (SD 2.9) years, thirty-six men and thirty-one women developed new MetS. After adjustments for confounders, the hazard ratio (HR) for the MetS in the highest tertile of serum beta-carotene against the lowest tertile was 0.47 (95 % CI 0.23, 0.95). On the other hand, significantly lower risks for dyslipidaemia were observed in the highest tertiles of serum alpha- and beta-carotene and beta-cryptoxanthin (HR 0.66; 95 % CI 0.46, 0.96; HR, 0.54; 95 % CI 0.37, 0.79; and HR 0.66; 95 % CI 0.44, 0.99, respectively). Other significant associations between the risks for obesity, high blood pressure and hyperglycaemia with serum carotenoids were not observed. Our results further support the hypothesis that eating a diet rich in carotenoids might help prevent the development of the MetS and its complications in Japanese subjects.
C1 [Sugiura, Minoru; Ogawa, Kazunori; Ikoma, Yoshinori; Yano, Masamichi] Natl Agr & Food Res Org, NARO Inst Fruit Tree Sci, Citrus Res Div, Shizuoka, Shizuoka 4240292, Japan.
   [Nakamura, Mieko] Hamamatsu Univ Sch Med, Dept Community Hlth & Prevent Med, Hamamatsu, Shizuoka 4313192, Japan.
C3 National Agriculture & Food Research Organization - Japan; Hamamatsu
   University School of Medicine
RP Sugiura, M (corresponding author), Natl Agr & Food Res Org, NARO Inst Fruit Tree Sci, Citrus Res Div, 485-6 Okitsu Nakachou, Shizuoka, Shizuoka 4240292, Japan.
EM msugiura@affrc.go.jp
RI Nakamura, Mieko/AFS-0483-2022
FU Ministry of Agriculture, Forestry, and Fisheries (MAFF); Council for the
   Advancement of Fruit Tree Science
FX This work was supported by a grant from the Ministry of Agriculture,
   Forestry, and Fisheries (MAFF) for a food research project titled
   'Research project on the development of agricultural products and foods
   with health-promoting benefits (NARO)' and a grant from the Council for
   the Advancement of Fruit Tree Science.
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NR 58
TC 43
Z9 47
U1 0
U2 12
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1145
EI 1475-2662
J9 BRIT J NUTR
JI Br. J. Nutr.
PD NOV 28
PY 2015
VL 114
IS 10
BP 1674
EP 1682
DI 10.1017/S0007114515003268
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA CW4JP
UT WOS:000364957900015
PM 26365147
OA Bronze
DA 2025-06-11
ER

PT J
AU Imai, Y
   Dobrian, AD
   Morris, MA
   Nadler, JL
AF Imai, Yumi
   Dobrian, Anca D.
   Morris, Margaret A.
   Nadler, Jerry L.
TI Islet inflammation: a unifying target for diabetes treatment?
SO TRENDS IN ENDOCRINOLOGY AND METABOLISM
LA English
DT Review
DE beta cell; adipocyte; cytokine; immune cells; obesity; clinical trials
ID BETA-CELL APOPTOSIS; ENDOPLASMIC-RETICULUM STRESS;
   THIOREDOXIN-INTERACTING PROTEIN; INSULIN-SECRETION; ADIPOSE-TISSUE; ER
   STRESS; NOD MICE; PROINFLAMMATORY CYTOKINES; NLRP3 INFLAMMASOME;
   METABOLIC SYNDROME
AB In the past decade, islet inflammation has emerged as a contributor to the loss of functional beta cell mass in both type 1 (T1D) and type 2 diabetes (T2D). Evidence supports the idea that overnutrition and insulin resistance result in the production of proinflammatory mediators by beta cells. In addition to compromising beta cell function and survival, cytokines may recruit macrophages into islets, thus augmenting inflammation. Limited but intriguing data imply a role of adaptive immune response in islet dysfunction in T2D. Clinical trials have validated anti-inflammatory therapies in T2D, whereas immune therapy for T1D remains challenging. Further research is required to improve our understanding of islet inflammatory pathways and to identify more effective therapeutic targets for T1D and T2D.
C1 [Imai, Yumi; Morris, Margaret A.; Nadler, Jerry L.] Eastern Virginia Med Sch, Strelitz Diabet Ctr, Dept Internal Med, Norfolk, VA 23507 USA.
   [Dobrian, Anca D.] Eastern Virginia Med Sch, Dept Physiol Sci, Norfolk, VA 23507 USA.
   [Morris, Margaret A.] Eastern Virginia Med Sch, Dept Microbiol & Mol Cell Biol, Norfolk, VA 23507 USA.
C3 Eastern Virginia Medical School; Eastern Virginia Medical School;
   Eastern Virginia Medical School
RP Imai, Y (corresponding author), Eastern Virginia Med Sch, Strelitz Diabet Ctr, Dept Internal Med, Norfolk, VA 23507 USA.
EM imaiy@evms.edu; nadlerjl@evms.edu
RI Imai, Yumi/IWE-1907-2023
OI Imai, Yumi/0000-0001-5046-4223
FU Juvenile Research Foundation; American Diabetes Association; National
   Institutes of Health [R01-111112605, R01-DK090490]; Ferguson and Iacocca
   Foundation; Merck
FX We apologize that we were unable to cite many outstanding studies
   performed by investigators in the field owing to space limitations.
   Funding support was obtained from the Juvenile Research Foundation
   (J.L.N.), American Diabetes Association (M.A.M.), National Institutes of
   Health (R01-111112605 to J.L.N., R01-DK090490 to Y.I.), the Ferguson and
   Iacocca Foundation (J.L.N.), and Merck (A.D.D.).
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NR 98
TC 96
Z9 108
U1 0
U2 15
PU ELSEVIER SCIENCE LONDON
PI LONDON
PA 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND
SN 1043-2760
EI 1879-3061
J9 TRENDS ENDOCRIN MET
JI Trends Endocrinol. Metab.
PD JUL
PY 2013
VL 24
IS 7
BP 351
EP 360
DI 10.1016/j.tem.2013.01.007
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 183EB
UT WOS:000321795900005
PM 23484621
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Mehta, AA
   Agrawal, AD
   Appanna, V
   Chaudagar, KK
AF Mehta, Anita A.
   Agrawal, Ashok D.
   Appanna, Vasu
   Chaudagar, Kiranj K.
TI Vitamin D improves corticosteroid efficacy and attenuates its
   side-effects in an animal model of asthma
SO CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
LA English
DT Article
DE ovalbumin; dexamethasone; single dose; bolus dose
ID MESSENGER-RNA EXPRESSION; LOW-DENSITY-LIPOPROTEIN; 1,25-DIHYDROXYVITAMIN
   D-3; IMMUNE-SYSTEM; 1-ALPHA,25-DIHYDROXYVITAMIN D-3;
   TYROSINE-HYDROXYLASE; METABOLIC SYNDROME; T-CELLS; RECEPTOR; INSULIN
AB The subacute use of corticosteroids has side-effects such as glucose intolerance, dyslipidemia, anxiety, and depression, which could be halted with vitamin D, which is an immunomodulatory vitamin. Thus, we aimed to study the anti-asthmatic efficacy and side-effects profile of vitamin D, the corticosteroid dexamethasone, and their combination on ovalbumin-induced airway inflammation in rats. For this, 2 different doses of vitamin D (50 IU/kg, daily for 2 weeks, or and 60000 IU/kg, bolus dose, by intraperitoneal injection (i.p.)) were administered in combination with dexamethasone (2.5 mg/kg, i.p., for 2 weeks) prior to challenge with ovalbumin. At the end of the therapy, the asthmatic parameters such as differential white blood cell counts, serum levels of immunoglobulin E, bronchoalveolar lavaged fluid, and interleukin-5, as well as serum levels of nitric oxide were significantly increased after allergen challenges in asthmatic rats as compared with the controls. Such increases were significantly attenuated by monotherapy with vitamin D and with combination therapy of vitamin D and dexamethasone, where the combination therapy was superior to the monotherapy. Dexamethasone-induced hyperglycemia, hyperlipidemia, and behavioral abnormalities in the allergic rats were attenuated with vitamin D. The daily dose was better for controlling serum levels of immunoglobulin E than the bolus dose, whereas the bolus was superior for reducing dexamethasone-induced psychotropic abnormalities. There were no significant changes in other parameters between the daily and the bolus dose. In conclusion, a daily dose of vitamin D in combination with dexamethasone is more efficacious for treating asthma in allergic rats than monotherapy.
C1 [Mehta, Anita A.; Agrawal, Ashok D.; Chaudagar, Kiranj K.] LM Coll Pharm, Dept Pharmacol, Ahmadabad 380009, Gujarat, India.
   [Mehta, Anita A.; Agrawal, Ashok D.] Gujarat Technol Univ, Gandhinagar, Gujarat, India.
   [Chaudagar, Kiranj K.] Laurentian Univ, Dept Chem & Biochem, Sudbury, ON P3E 2C6, Canada.
C3 Gujarat Technological University; Laurentian University
RP Mehta, AA (corresponding author), LM Coll Pharm, Dept Pharmacol, Ahmadabad 380009, Gujarat, India.
EM dranitalmcp@gmail.com
RI Agrawal, Ashok/ABE-2390-2021; Mehta, Anita/AAT-3504-2021
OI Mehta, Anita/0000-0001-7036-3833; Appanna, Vasu/0000-0002-0138-5665
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NR 80
TC 15
Z9 17
U1 0
U2 8
PU CANADIAN SCIENCE PUBLISHING
PI OTTAWA
PA 65 AURIGA DR, SUITE 203, OTTAWA, ON K2E 7W6, CANADA
SN 0008-4212
EI 1205-7541
J9 CAN J PHYSIOL PHARM
JI Can. J. Physiol. Pharmacol.
PD JAN
PY 2015
VL 93
IS 1
BP 53
EP 61
DI 10.1139/cjpp-2014-0323
PG 9
WC Pharmacology & Pharmacy; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Physiology
GA AY2FK
UT WOS:000347403800007
PM 25429688
DA 2025-06-11
ER

PT J
AU Vimaleswaran, KS
   Cavadino, A
   Verweij, N
   Nolte, IM
   Leach, IM
   Auvinen, J
   Veijola, J
   Elliott, P
   Penninx, BW
   Snieder, H
   Järvelin, MR
   van der Harst, P
   Cohen, RD
   Boucher, BJ
   Hyppönen, E
AF Vimaleswaran, Karani S.
   Cavadino, Alana
   Verweij, Niek
   Nolte, Ilja M.
   Leach, Irene Mateo
   Auvinen, Juha
   Veijola, Juha
   Elliott, Paul
   Penninx, Brenda W.
   Snieder, Harold
   Jarvelin, Marjo-Riitta
   van der Harst, Pim
   Cohen, Robert D.
   Boucher, Barbara J.
   Hyppoenen, Elina
CA LifeLines Cohort Study
TI Interactions between uncoupling protein 2 gene polymorphisms, obesity
   and alcohol intake on liver function: a large meta-analysed
   population-based study
SO EUROPEAN JOURNAL OF ENDOCRINOLOGY
LA English
DT Article
ID MIDDLE-AGED HUMANS; INSULIN-RESISTANCE; METABOLIC SYNDROME; RISK;
   ASSOCIATION; EXPRESSION; UCP2; PROMOTER; MEN; HEPATOCYTES
AB Background and objective: Given the role of uncoupling protein 2 (UCP2) in the accumulation of fat in the hepatocytes and in the enhancement of protective mechanisms in acute ethanol intake, we hypothesised that UCP2 polymorphisms are likely to cause liver disease through their interactions with obesity and alcohol intake. To test this hypothesis, we investigated the interaction between tagging polymorphisms in the UCP2 gene (rs2306819, rs599277 and rs659366), alcohol intake and obesity traits such as BMI and waist circumference (WC) on alanine aminotransferase (ALT) and gamma glutamyl transferase (GGT) in a large meta-analysis of data sets from three populations (n=20 242).
   Design and methods: The study populations included the Northern Finland Birth Cohort 1966 (n=4996), Netherlands Study of Depression and Anxiety (n=1883) and LifeLines Cohort Study (n=13 363). Interactions between the polymorphisms and obesity and alcohol intake on dichotomised ALT and GGT levels were assessed using logistic regression and the likelihood ratio test.
   Results: In the meta-analysis of the three cohorts, none of the three UCP2 polymorphisms were associated with GGT or ALT levels. There was no evidence for interaction between the polymorphisms and alcohol intake on GGT and ALT levels. In contrast, the association of WC and BMI with GGT levels varied by rs659366 genotype (P-interaction=0.03 and 0.007, respectively; adjusted for age, gender, high alcohol intake, diabetes, hypertension and serum lipid concentrations).
   Conclusion: In conclusion, our findings in 20 242 individuals suggest that UCP2 gene polymorphisms may cause liver dysfunction through the interaction with body fat rather than alcohol intake.
C1 [Vimaleswaran, Karani S.] Univ Reading, Sch Chem Food & Pharm, Dept Food & Nutr Sci, Hugh Sinclair Unit Human Nutr, Reading RG6 6AP, Berks, England.
   [Vimaleswaran, Karani S.; Cavadino, Alana; Hyppoenen, Elina] UCL Inst Child Hlth, Populat Policy & Practice, London, England.
   [Cavadino, Alana] Queen Mary Univ London, Ctr Environm & Prevent Med, Wolfson Inst Prevent Med, London, England.
   [Verweij, Niek; Leach, Irene Mateo; van der Harst, Pim] Univ Groningen, Univ Med Ctr Groningen, Dept Cardiol, Groningen, Netherlands.
   [Nolte, Ilja M.; Snieder, Harold] Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, Groningen, Netherlands.
   [Auvinen, Juha; Jarvelin, Marjo-Riitta] Oulu Univ Hosp, Unit Primary Care, Oulu, Finland.
   [Auvinen, Juha; Jarvelin, Marjo-Riitta] Univ Oulu, Fac Med, Ctr Life Course Epidemiol, Oulu, Finland.
   [Veijola, Juha] Univ Oulu, Dept Psychiat, Ctr Clin Neurosci, Oulu, Finland.
   [Veijola, Juha] Univ Hosp Oulu, Dept Psychiat, Med Res Ctr, Oulu, Finland.
   [Elliott, Paul; Jarvelin, Marjo-Riitta] Univ London Imperial Coll Sci Technol & Med, MRC PHE Ctr Environm & Hlth, Dept Epidemiol & Biostat, London, England.
   [Penninx, Brenda W.] Leiden Univ, Med Ctr, Dept Psychiat, Leiden, Netherlands.
   [Penninx, Brenda W.] Vrije Univ Amsterdam, Med Ctr, EMGO Inst Hlth & Care Res, Dept Psychiat, Amsterdam, Netherlands.
   [Jarvelin, Marjo-Riitta] Univ Oulu, Bioctr Oulu, Oulu, Finland.
   [van der Harst, Pim] Univ Groningen, Univ Med Ctr Groningen, Dept Genet, Groningen, Netherlands.
   [van der Harst, Pim] Durrer Ctr Cardiogenet Res, ICIN Netherlands Heart Inst, Utrecht, Netherlands.
   [Cohen, Robert D.; Boucher, Barbara J.] Queen Mary Univ London, Blizard Inst, Barts & London Sch Med & Dent, London, England.
   [Hyppoenen, Elina] Univ S Australia, Ctr Populat Hlth Res, Sch Hlth Sci, Adelaide, SA 5001, Australia.
   [Hyppoenen, Elina] Univ S Australia, Sansom Inst Hlth Res, Adelaide, SA 5001, Australia.
   [Hyppoenen, Elina] South Australian Hlth & Med Res Inst, Adelaide, SA, Australia.
C3 University of Reading; University of London; University College London;
   University of London; Queen Mary University London; University of
   Groningen; University of Groningen; University of Oulu; University of
   Oulu; University of Oulu; Imperial College London; Leiden University;
   Leiden University Medical Center (LUMC); Leiden University - Excl LUMC;
   Vrije Universiteit Amsterdam; University of Oulu; University of
   Groningen; University of London; Queen Mary University London;
   University of South Australia; University of South Australia; South
   Australian Health & Medical Research Institute (SAHMRI)
RP Vimaleswaran, KS (corresponding author), Univ Reading, Sch Chem Food & Pharm, Dept Food & Nutr Sci, Hugh Sinclair Unit Human Nutr, POB 226, Reading RG6 6AP, Berks, England.
EM v.karani@reading.ac.uk
RI Verweij, Niek/ABC-6249-2021; Penninx, Brenda/S-7627-2017; Cavadino,
   Alana/CAG-8915-2022; Coin, Lachlan/A-9001-2014; van der Harst,
   Pim/HOH-5622-2023; Hypponen, Elina/B-2596-2014; Alizadeh, Behrooz
   Z./J-2921-2017
OI Cavadino, Alana/0000-0002-5709-367X; Karani, Vimal/0000-0002-8485-8930;
   van der Harst, Pim/0000-0002-2713-686X; Jarvelin,
   Marjo-Riitta/0000-0002-2149-0630; Hypponen, Elina/0000-0003-3670-9399;
   Alizadeh, Behrooz Z./0000-0002-1415-8007; Verweij,
   Niek/0000-0002-4303-7685; Elliott, Paul/0000-0002-7511-5684
FU British Heart Foundation [PG/09/023]; Academy of Finland; NHS Executive;
   Medical Research Council; Public Health England; NIHR Biomedical
   Research Centre at Imperial College Healthcare NHS Trust; Imperial
   College London; NIHR Health Protection Research Unit on Health Effects
   of Environmental Hazards; Netherlands Organization of Scientific
   Research NWO [175.010.2007.006]; Economic Structure Enhancing Fund (FES)
   of the Dutch government; Ministry of Economic Affairs; Ministry of
   Education, Culture and Science; Ministry for Health, Welfare and Sports;
   Northern Netherlands Collaboration of Provinces (SNN); Province of
   Groningen; University Medical Center Groningen; University of Groningen;
   Dutch Kidney Foundation; Dutch Diabetes Research Foundation; Academy of
   Finland (Center of Excellence in Complex Disease Genetics and SALVE)
   [104781, 120315, 129269, 1114194, 24300796]; University Hospital Oulu;
   Biocenter; University of Oulu, Finland [75617]; NHLBI through the
   STAMPEED program [5R01HL087679-02, 1RL1MH083268-01]; NIH/NIMH
   [5R01MH63706:02]; ENGAGE project [HEALTH-F4-2007-201413]; EU FP7
   EurHEALTHAgeing [277849]; Medical Research Council, UK [G0500539,
   G0600705, G1002319]; MRC, Centenary Early Career Award; DynaHEALTH
   action [H2020-633595]; academy of the Finland EGEA-project; Biocentrum
   Helsinki; MRC [G1002319, G0600705, MR/L01341X/1] Funding Source: UKRI
FX The study was supported by the British Heart Foundation (grant number
   PG/09/023) and the Academy of Finland. Research at the University
   College London, Institute of Child Health, and Great Ormond Street
   Hospital for Children National Health Service (NHS) Trust benefits from
   research and development funding received from the NHS Executive. P
   Elliott is director of the MRC-PHE Centre for Environment and Health and
   acknowledges support from the Medical Research Council and Public Health
   England. P Elliott is a National Institute for Health Research (NIHR)
   senior investigator and acknowledges support from the NIHR Biomedical
   Research Centre at Imperial College Healthcare NHS Trust and Imperial
   College London and the NIHR Health Protection Research Unit on Health
   Effects of Environmental Hazards. LifeLines Cohort Study: The LifeLines
   Cohort Study, and generation and management of genome-wide association
   studies (GWAS) genotype data for the LifeLines Cohort Study, is
   supported by The Netherlands Organization of Scientific Research
   NWO(grant number 175.010.2007.006); Economic Structure Enhancing Fund
   (FES) of the Dutch government; Ministry of Economic Affairs; the
   Ministry of Education, Culture and Science; Ministry for Health, Welfare
   and Sports; the Northern Netherlands Collaboration of Provinces (SNN);
   Province of Groningen; University Medical Center Groningen; University
   of Groningen; Dutch Kidney Foundation and Dutch Diabetes Research
   Foundation. Northern Finland Birth Cohort 1966: NFBC 1966 received
   financial support from the Academy of Finland (project grants 104781,
   120315, 129269, 1114194 and 24300796, Center of Excellence in Complex
   Disease Genetics and SALVE); University Hospital Oulu, Biocenter,
   University of Oulu, Finland (75617); NHLBI grant number 5R01HL087679-02
   through the STAMPEED program (1RL1MH083268-01); NIH/NIMH
   (5R01MH63706:02); ENGAGE project and grant agreement
   HEALTH-F4-2007-201413; EU FP7 EurHEALTHAgeing, 277849; Medical Research
   Council, UK (G0500539, G0600705, G1002319, PrevMetSyn/SALVE) and the
   MRC, Centenary Early Career Award. The program is currently being funded
   by the H2020-633595 DynaHEALTH action and academy of the Finland
   EGEA-project. The DNA extractions, sample QCs, biobank upkeeping and
   aliquotting was performed in the National Public Health Institute,
   Biomedicum Helsinki, Finland, and supported financially by the Academy
   of Finland and Biocentrum Helsinki.
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NR 39
TC 10
Z9 10
U1 0
U2 16
PU BIOSCIENTIFICA LTD
PI BRISTOL
PA EURO HOUSE, 22 APEX COURT WOODLANDS, BRADLEY STOKE, BRISTOL BS32 4JT,
   ENGLAND
SN 0804-4643
EI 1479-683X
J9 EUR J ENDOCRINOL
JI Eur. J. Endocrinol.
PD DEC
PY 2015
VL 173
IS 6
BP 863
EP 872
DI 10.1530/EJE-15-0839
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA CV3KZ
UT WOS:000364159400019
PM 26526553
OA Green Submitted, hybrid
DA 2025-06-11
ER

PT J
AU Hasani, M
   Khazdouz, M
   Sobhani, S
   Mardi, P
   Riahi, S
   Agh, F
   Mahdavi-Gorabi, A
   Mohammadipournami, S
   Gomnam, F
   Qorbani, M
AF Hasani, Motahareh
   Khazdouz, Maryam
   Sobhani, Sahar
   Mardi, Parham
   Riahi, Shirin
   Agh, Fahimeh
   Mahdavi-Gorabi, Armita
   Mohammadipournami, Sahar
   Gomnam, Fatemeh
   Qorbani, Mostafa
TI Association of heavy metals and bio-elements blood level with metabolic
   syndrome: a systematic review and meta-analysis of observational studies
SO JOURNAL OF DIABETES AND METABOLIC DISORDERS
LA English
DT Review
DE Metabolic syndrome; Heavy metals; Elements; Cadmium; Mercury; Chromium;
   Heavy metal poisoning; Trace elements
ID KOREA NATIONAL-HEALTH; CADMIUM EXPOSURE; MERCURY CONCENTRATION;
   INSULIN-RESISTANCE; DIABETES-MELLITUS; OXIDATIVE STRESS; URINARY
   CADMIUM; TRACE-ELEMENTS; SERUM FERRITIN; SYNDROME RISK
AB Background and objectives The literature has reported heavy metals might alter the physiological and biochemical functions of body organs and cause several health problems. So, the present systematic review and meta-analysis aimed to investigate the association of blood levels of essential or non-essential metals with metabolic syndrome (MetS). Methods In this systematic review, some international databases including PubMed, Embase, Scopus, and Web of Science were searched up to February 2024. All observational studies which assessed the association of three heavy metals (cadmium, mercury, lead) and bio-elements (chromium, iron, manganese, and magnesium, copper) with the risk of MetS were included. There was no limitation in the time of publication and language. A random-effects meta-analysis was performed to estimate the pooled effect sizes. Possible sources of heterogeneity were explored by meta-regression analysis. Results Totally, 29 studies were eligible for meta-analysis. Our results showed that increased level of cadmium (pooled OR: 1.24, 95% CI: 1.05, 1.46) and mercury (pooled OR: 1.22, 95% CI: 1.08, 1.38) significantly increased the risk of MetS. In contrast, increased level of chromium significantly reduced the risk of developing MetS (pooled OR: 0.68, 95% CI: 0.56, 0.83). Moreover, association between lead, iron, copper, magnesium, and manganese with MetS was not statistically significant (P > 0.05). However, elevated lead levels in men increased the odds of MetS. Conclusion Our results show a significant association between blood levels of some heavy metals, including cadmium, mercury, and lead, with increased odds of MetS. On the other hand, chromium as a biometal decreased the odds of MetS.
C1 [Hasani, Motahareh] Golestan Univ Med Sci, Sch Publ Hlth, Dept Nutr, Gorgan, Iran.
   [Khazdouz, Maryam] Iran Univ Med Sci, Ali Asghar Childrens Hosp, Tehran, Iran.
   [Sobhani, Sahar; Mardi, Parham; Qorbani, Mostafa] Alborz Univ Med Sci, Noncommunicable Dis Res Ctr, Karaj, Iran.
   [Riahi, Shirin] Mazandaran Univ Med Sci, Educ Dev Ctr, Karaj, Iran.
   [Agh, Fahimeh] Saveh Univ Med Sci, Saveh, Iran.
   [Mohammadipournami, Sahar; Gomnam, Fatemeh] Alborz Univ Med Sci, Student Res Comm, Noncommunicable Dis Res Ctr, Karaj, Iran.
   [Gomnam, Fatemeh] Alborz Univ Med Sci, Sch Hlth, Dept Environm Hlth, Karaj, Iran.
   [Qorbani, Mostafa] Alborz Univ Med Sci, Sch Hlth, Dept Biostat & Epidemiol, Karaj, Iran.
   [Mahdavi-Gorabi, Armita] Univ Tehran Med Sci, Mol Med & Genet Res Ctr Adv Technol Cardiovasc Med, Tehran, Iran.
C3 Golestan University of Medical Sciences; Iran University of Medical
   Sciences; Alborz University of Medical Sciences; Mazandaran University
   of Medical Sciences; Alborz University of Medical Sciences; Alborz
   University of Medical Sciences; Alborz University of Medical Sciences;
   Tehran University of Medical Sciences
RP Qorbani, M (corresponding author), Alborz Univ Med Sci, Noncommunicable Dis Res Ctr, Karaj, Iran.; Gomnam, F (corresponding author), Alborz Univ Med Sci, Student Res Comm, Noncommunicable Dis Res Ctr, Karaj, Iran.; Gomnam, F (corresponding author), Alborz Univ Med Sci, Sch Hlth, Dept Environm Hlth, Karaj, Iran.; Qorbani, M (corresponding author), Alborz Univ Med Sci, Sch Hlth, Dept Biostat & Epidemiol, Karaj, Iran.
EM Fatemegomnam1401@yahoo.com; mqorbani1379@yahoo.com
RI Qorbani, Mostafa/M-8171-2017; sobhani, sahar/ABB-1010-2020; Agh,
   Fahimeh/ABC-1794-2021; Hasani, Motahareh/AAY-8608-2020; riahi,
   shirin/R-2460-2017; khazdouz, maryam/AAB-3490-2021
FU Alborz University of Medical Sciences; Alborz University of Medical
   Sciences
FX The authors would like to acknowledge the Clinical Research Development
   Unit of Imam Ali Hospital, Karaj, for their administrative help. This
   study was approved and funded by Alborz University of Medical Sciences.
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NR 97
TC 2
Z9 2
U1 8
U2 8
PU SPRINGER INT PUBL AG
PI CHAM
PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND
EI 2251-6581
J9 J DIABETES METAB DIS
JI J. Diabetes Metab. Disord.
PD DEC
PY 2024
VL 23
IS 2
BP 1719
EP 1752
DI 10.1007/s40200-024-01500-9
EA NOV 2024
PG 34
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA N4L5Z
UT WOS:001349325700001
PM 39610503
DA 2025-06-11
ER

PT J
AU Menezes, A
   Peixoto, M
   Silva, M
   Costa-Bartuli, E
   Oliveira, CL
   Walter-Nuno, AB
   Kistenmacker, N
   Pereira, J
   Ramos, I
   Paiva-Silva, GO
   Atella, GC
   Zancan, P
   Sola-Penna, M
   Gomes, FM
AF Menezes, Alexandre
   Peixoto, Marilia
   Silva, Melissa
   Costa-Bartuli, Emylle
   Oliveira, Cinara Lima
   Walter-Nuno, Ana Beatriz
   da Cruz Kistenmacker, Nathan
   Pereira, Jessica
   Ramos, Isabela
   Paiva-Silva, Gabriela O.
   Atella, Georgia C.
   Zancan, Patricia
   Sola-Penna, Mauro
   Gomes, Fabio M.
TI Western diet consumption by host vertebrate promotes altered gene
   expression on Aedes aegypti reducing its lifespan and increasing
   fertility following blood feeding
SO PARASITES & VECTORS
LA English
DT Article
DE Metabolic syndrome; Western diet; Malnutrition; Immunometabolism; Aedes
   aegypti; Vector capacity; Vector competence; Blood feeding
ID OXIDATIVE STRESS; MOSQUITO; INSULIN; PATHWAY; OBESITY; INTEGRATION;
   ACTIVATION; LIPOPHORIN; BODY; AKT
AB Background The high prevalence of metabolic syndrome in low- and middle-income countries is linked to an increase in Western diet consumption, characterized by a high intake of processed foods, which impacts the levels of blood sugar and lipids, hormones, and cytokines. Hematophagous insect vectors, such as the yellow fever mosquito Aedes aegypti, rely on blood meals for reproduction and development and are therefore exposed to the components of blood plasma. However, the impact of the alteration of blood composition due to malnutrition and metabolic conditions on mosquito biology remains understudied.Methods In this study, we investigated the impact of whole-blood alterations resulting from a Western-type diet on the biology of Ae. aegypti. We kept C57Bl6/J mice on a high-fat, high-sucrose (HFHS) diet for 20 weeks and followed biological parameters, including plasma insulin and lipid levels, insulin tolerance, and weight gain, to validate the development of metabolic syndrome. We further allowed Ae. aegypti mosquitoes to feed on mice and tracked how altered host blood composition modulated parameters of vector capacity.Results Our findings identified that HFHS-fed mice resulted in reduced mosquito longevity and increased fecundity upon mosquito feeding, which correlated with alteration in the gene expression profile of nutrient sensing and physiological and metabolic markers as studied up to several days after blood ingestion.Conclusions Our study provides new insights into the overall effect of alterations of blood components on mosquito biology and its implications for the transmission of infectious diseases in conditions where the frequency of Western diet-induced metabolic syndromes is becoming more frequent. These findings highlight the importance of addressing metabolic health to further understand the spread of mosquito-borne illnesses in endemic areas.
C1 [Menezes, Alexandre; Peixoto, Marilia; Silva, Melissa; da Cruz Kistenmacker, Nathan; Gomes, Fabio M.] Univ Fed Rio de Janeiro, Lab Ultraestrutura Celular Hertha Meyer, Rio De Janeiro, Brazil.
   [Costa-Bartuli, Emylle; Zancan, Patricia; Sola-Penna, Mauro] Univ Fed Rio de Janeiro, Fac Farm, Dept Biotecnol Farmaceut, Metabolizsm Grp, Rio De Janeiro, Brazil.
   [Oliveira, Cinara Lima; Atella, Georgia C.] Univ Fed Rio de Janeiro, Lab Bioquim Lipideos & Lipoproteinas, Inst Bioquim Med Leopoldo De Meis, Rio De Janeiro, Brazil.
   [Walter-Nuno, Ana Beatriz; Paiva-Silva, Gabriela O.] Univ Fed Rio de Janeiro, Lab Bioquim Artropodes Hematofagos, Rio De Janeiro, Brazil.
   [Walter-Nuno, Ana Beatriz; Ramos, Isabela] Inst Nacl Ciencia & Tecnol Entomol Mol, Rio De Janeiro, Brazil.
   [Pereira, Jessica; Ramos, Isabela; Paiva-Silva, Gabriela O.; Atella, Georgia C.; Gomes, Fabio M.] Univ Fed Rio de Janeiro, Lab Ovogenese Mol Insetos Vetores, Rio De Janeiro, Brazil.
C3 Universidade Federal do Rio de Janeiro; Universidade Federal do Rio de
   Janeiro; Universidade Federal do Rio de Janeiro; Universidade Federal do
   Rio de Janeiro; Universidade Federal do Rio de Janeiro
RP Gomes, FM (corresponding author), Univ Fed Rio de Janeiro, Lab Ultraestrutura Celular Hertha Meyer, Rio De Janeiro, Brazil.; Gomes, FM (corresponding author), Univ Fed Rio de Janeiro, Lab Ovogenese Mol Insetos Vetores, Rio De Janeiro, Brazil.
EM fabiomg@biof.ufrj.br
RI Atella, Georgia/AAK-7897-2020; Ramos, Isabela/N-7091-2017; Sola-Penna,
   Mauro/E-8221-2011; Paiva-SIlva, Gabriela/L-3726-2018; Zancan,
   Patricia/Q-6281-2016
OI Costa Bartuli, Emylle/0000-0003-0334-5357
FU Fundao Carlos Chagas Filho de Amparo Pesquisa do Estado do Rio de
   Janeiro
FX We thank Jaciara Miranda Freire for insect rearing. We thank Prof
   Marcelo Bozza for donating AG129 mice.
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NR 77
TC 0
Z9 0
U1 3
U2 4
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1756-3305
J9 PARASITE VECTOR
JI Parasites Vectors
PD JAN 6
PY 2024
VL 17
IS 1
AR 12
DI 10.1186/s13071-023-06095-3
PG 12
WC Parasitology; Tropical Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Parasitology; Tropical Medicine
GA EE4F8
UT WOS:001137223200001
PM 38184590
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Ding, J
   Liu, Q
   Liu, Z
   Guo, HB
   Liang, JY
   Zhang, Y
AF Ding, Jun
   Liu, Qi
   Liu, Ze
   Guo, Hongbin
   Liang, Jieyu
   Zhang, Yi
TI Associations of the Dietary Iron, Copper, and Selenium Level With
   Metabolic Syndrome: A Meta-Analysis of Observational Studies
SO FRONTIERS IN NUTRITION
LA English
DT Review
DE dietary iron level; dietary copper level; dietary selenium level;
   metabolic syndrome; meta-analysis; observational studies
ID OXIDATIVE STRESS; SERUM; RISK; MEAT; DEFICIENCY; ADULTS; ZINC
AB Background: Epidemiological studies have investigated the associations of dietary iron, copper, and selenium level with metabolic syndrome (MetS). However, their results are conflicting. This meta-analysis of observational study was, therefore, employed to investigate the associations above.Methods: A comprehensive literature search was employed using PubMed, Web of Science, Embase, and Scopus database up to October 2021 (no restriction was set for the initiate time). The pooled relative risk (RR) of MetS for the highest vs. lowest dietary iron, copper, and selenium level was estimated, respectively.Results: A total of 14 observational studies (55,131 participants) were identified as meeting the inclusion criteria. Specifically, 7 studies were related to the dietary iron level. The overall multivariable adjusted RR demonstrated that the dietary iron level was positively associated with MetS (RR = 1.27, 95% CI: 1.12-1.44; p < 0.001). With regard to the dietary copper level, 7 studies were included for meta-analysis. The overall multivariable adjusted RR showed that the dietary copper level was inversely associated with MetS (RR = 0.85, 95% CI: 0.78-0.93; p < 0.001). In addition, 4 studies were specified for the dietary selenium level. The overall multivariable adjusted RR indicated that the dietary selenium level was inversely associated with MetS (RR = 0.77, 95% CI: 0.63-0.95; p = 0.01) as well.Conclusion: Our results suggest that the dietary iron level is positively associated with MetS, whereas a negative association between the dietary copper and selenium level and MetS is obtained. Further large well-designed prospective cohort studies are warranted to elaborate on the issues examined in this study.
C1 [Ding, Jun] Changsha Social Work Coll, Changsha, Peoples R China.
   [Liu, Qi; Liu, Ze; Guo, Hongbin; Liang, Jieyu; Zhang, Yi] Cent South Univ, Xiangya Hosp, Dept Orthpaed, Changsha, Peoples R China.
   [Guo, Hongbin; Liang, Jieyu; Zhang, Yi] Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha, Peoples R China.
C3 Changsha Social Work College; Central South University; Central South
   University
RP Zhang, Y (corresponding author), Cent South Univ, Xiangya Hosp, Dept Orthpaed, Changsha, Peoples R China.; Zhang, Y (corresponding author), Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha, Peoples R China.
EM zhangyi0205@csu.edu.cn
RI Guo, Hongbin/ABA-7900-2021; Zhang, Yi/U-8628-2017; Ding,
   Jun/ABH-1012-2021; 梁, 捷予/GQH-8556-2022
FU National Natural Science Foundation of China [82102581]; National
   Postdoctoral Science Foundation of China [2021M693562]; Provincial
   Outstanding Postdoctoral Innovative Talents Program of Hunan
   [2021RC2020]; Provincial Natural Science Foundation of Hunan
   [2019JJ40517]; Young Investigator Grant of Xiangya Hospital, Central
   South University [2020Q14]; Fuqing Postdoc Program of Xiangya Hospital,
   Central South University [176]
FX Funding This study was supported by the National Natural Science
   Foundation of China (82102581), the National Postdoctoral Science
   Foundation of China (2021M693562), the Provincial Outstanding
   Postdoctoral Innovative Talents Program of Hunan (2021RC2020), the
   Provincial Natural Science Foundation of Hunan (2019JJ40517), the Young
   Investigator Grant of Xiangya Hospital, Central South University
   (2020Q14), and the Fuqing Postdoc Program of Xiangya Hospital, Central
   South University (176).
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NR 61
TC 15
Z9 15
U1 0
U2 6
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD FEB 1
PY 2022
VL 8
AR 810494
DI 10.3389/fnut.2021.810494
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA ZH6MS
UT WOS:000761051200001
PM 35178418
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Kalita, H
   Hazarika, A
   Devi, R
AF Kalita, Himadri
   Hazarika, Ankita
   Devi, Rajlakshmi
TI Withdrawal of High-Carbohydrate, High-Fat Diet Alters Status of Trace
   Elements to Ameliorate Metabolic Syndrome in Rats With Type 2 Diabetes
   Mellitus
SO CANADIAN JOURNAL OF DIABETES
LA English
DT Article
DE high-carbohydrate; high-fat diet; metabolic syndrome; oxidative stress;
   reactive oxygen species; trace element
ID ZINC; COPPER; SERUM
AB Objectives: Inadequate nutrient supply and insulin resistance contribute to the pathogenesis of metabolic syndrome (MetS) and increase the risk of developing cardiovascular disease. MetS can be induced by prolonged feeding of a high-carbohydrate, high-fat (HCHF) diet. The present study was designed using Wistar albino rats as an experimental model to investigate the effect of subchronic withdrawal of an HCHF diet during MetS on distribution of copper (Cu), iron (Fe), magnesium (Mg), manganese (Mn), zinc (Zn) and chromium (Cr) in different biological media.
   Methods: The experimental animals were fed an HCHF diet for up to 16 weeks for induction of MetS. After inducing MetS, some animals were shifted to a basal diet for the next 4 weeks. Distribution of trace elements (TE) in serum, liver and faeces at the different time intervals and their relationship with dietary TE were analyzed.
   Results: On withdrawal of the HCHF diet, concentrations of Zn, Mg, Mn (serum, p<0.05; liver, p<0.001) and Cr were increased, and Cu and Fe were decreased in serum and liver at week 16. Furthermore, levels of Cu and Fe were reduced significantly (p<0.05) in faeces on feeding the HCHF diet and increased on withdrawal of the diet, which also reflects the metabolic fate of TE during MetS.
   Conclusions: Consumption of an HCHF diet over a long time period leads to alteration of the TE profile in serum, liver and feces during MetS, which is reversed upon dietary intervention. This can be correlated with their concentrations in HCHF and basal diets, and hence can contribute to proper dietary control of this global issue. (C) 2019 Canadian Diabetes Association.
C1 [Kalita, Himadri; Hazarika, Ankita; Devi, Rajlakshmi] Inst Adv Study Sci & Technol, Life Sci Div, Gauhati 781035, Assam, India.
C3 Department of Science & Technology (India); Institute of Advanced Study
   in Science & Technology (IASST)
RP Devi, R (corresponding author), Inst Adv Study Sci & Technol, Life Sci Div, Gauhati 781035, Assam, India.
EM biochemistry.iasst@gmail.com
FU Department of Science and Technology, Government of India, New Delhi
FX The authors acknowledge Department of Science and Technology, Government
   of India, New Delhi, for financial support. We are thankful to the
   Institute of Advanced Study in Science and Technology (IASST), Guwahati,
   Assam, India, for providing the necessary facilities. We also
   acknowledge Juri Pathak (technical officer at IASST) for technical help
   with FAAS.
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NR 30
TC 14
Z9 14
U1 1
U2 8
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1499-2671
J9 CAN J DIABETES
JI Can. J. Diabetes
PD JUN
PY 2020
VL 44
IS 4
BP 317
EP +
DI 10.1016/j.jcjd.2019.10.001
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA MM2GU
UT WOS:000549976300007
PM 32165144
DA 2025-06-11
ER

PT J
AU Rostami, H
   Tavakoli, HR
   Rahimi, MH
   Mohammadi, M
AF Rostami, Hosein
   Tavakoli, Hamid Reza
   Rahimi, Mohammad Hossein
   Mohammadi, Mohammad
TI Metabolic Syndrome Prevalence among Armed Forces Personnel (Military
   Personnel and Police Officers): A Systematic Review and Meta-Analysis
SO MILITARY MEDICINE
LA English
DT Review
ID CARDIOVASCULAR-DISEASE RISK; SLEEP DURATION; ASSOCIATION; QUALITY;
   STRESS; CHOLESTEROL; POPULATION; REDUCTION; PROGRAM; OBESITY
AB Introduction: Metabolic syndrome (MetS) is closely linked to type 2 diabetes and cardiovascular disease. Various studies have reported the prevalence of MetS in different armed forces personnel in different countries. However, performing a systematic review and meta-analysis on this subject seems necessary. The aim of this study was to estimate the pooled prevalence of MetS among armed forces personnel including members of the military and police forces. Materials and Methods: A systematic review was carried out on all associated papers published in PubMed, Scopus, Web of Science and Cochrane Library, encompassing the timeframe: November, 2018 to January 2000. The overall prevalence of MetS, and its prevalence based on different diagnostic criteria [National Cholesterol Education Program-Adult Treatment Panel III (NCEP-ATP III), American Heart Association (AHA) and International Diabetes Federation (IDF)] were pooled using a random-effects model. Results: Twenty five eligible studies were selected for the meta-analysis. Among all police officers contained in this study group, the overall prevalence of MetS was 26.2% (95% CI: 19.7-34%; Q = 229.45, p = 0.00). Among different military personnel contained in this study group, the overall estimation of MetS prevalence was 8.3% (95% CI: 6.3-11%; Q = 540.88, p = 0.00) the prevalence of MetS was 8.0% (95% CI: 5.7-11%; Q = 409.76, p = 0.00) according to the NCEP-ATP III criterion. Conclusion: The findings from the present meta-analyses displayed a low prevalence of metabolic syndrome in armed forces in general. These findings will allow healthcare providers and policy-makers to find solutions in order to take action to reduce MetS risks on a wider scale, especially among police officers.
C1 [Rostami, Hosein; Tavakoli, Hamid Reza; Rahimi, Mohammad Hossein] Baqiyatallah Univ Med Sci, Life Style Inst, Hlth Res Ctr, Tehran, Iran.
   [Rahimi, Mohammad Hossein] Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Community Nutr, Tehran, Iran.
   [Mohammadi, Mohammad] Shahid Sadoughi Univ Med Sci, Nutr & Food Secur Res Ctr, Yazd, Iran.
   [Mohammadi, Mohammad] Shahid Sadoughi Univ Med Sci, Sch Publ Hlth, Dept Nutr, Yazd, Iran.
C3 Baqiyatallah University of Medical Sciences (BMSU); Tehran University of
   Medical Sciences; Shahid Sadoughi University of Medical Sciences; Shahid
   Sadoughi University of Medical Sciences
RP Rostami, H (corresponding author), Baqiyatallah Univ Med Sci, Life Style Inst, Hlth Res Ctr, Tehran, Iran.
RI Mohammadi, Mohammad/M-8068-2017
OI Rahimi, Mohammad Hossein/0000-0002-8610-346X
FU Baqiyatallah University of Medical Sciences
FX The authors would like to acknowledge Baqiyatallah University of Medical
   Sciences for the funding to conduct this study.
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U1 0
U2 3
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD SEP-OCT
PY 2019
VL 184
IS 9-10
BP E415
EP E422
DI 10.1093/milmed/usz144
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA JN5MC
UT WOS:000496941400006
PM 31247092
OA Bronze
DA 2025-06-11
ER

PT J
AU Attaran, S
   Yokoyama, W
   Pan, J
   Berrios, JD
AF Attaran, Shireen
   Yokoyama, Wallace
   Pan, James
   Berrios, Jose De J.
TI Influence of extruded lentil containing high chromium nutritional yeast
   on the main physiological factors associated with metabolic syndrome in
   rodent models
SO FOOD & FUNCTION
LA English
DT Article
ID GLUCOSE-TOLERANCE; INSULIN; SUPPLEMENTATION; LIPIDS; CHOLESTEROL;
   SECRETION; OBESITY; STRESS
AB Insulin resistance, obesity and dyslipidemia are the main physiological factors associated with metabolic syndrome. The objectives of this study were to understand the effects of diets containing extruded lentil fortified with high chromium nutritional yeast (YCr) or chromium picolinate on glucose tolerance, clearance and fasting blood glucose concentrations in Normal and Obese (Ob/Ob) mice and to determine the effects of the diets on the mice plasma lipid profiles. Diets A, B and C contained YCr in different doses and concentrations, as follows: Diet A = 15.7 g and 16 ppm, B = 157.1 g and 16 ppm, and C = 299.3 g and 27 ppm, respectively. Diet D contained chromium picolinate at a dose and concentration of 15.7 g and 16 ppm, respectively. Intraperitoneal glucose tolerance tests and intraperitoneal insulin tolerance tests were conducted at 4-weeks and 8-weeks post diet initiation, in addition to, plasma lipoprotein profiles and organ weights. Normal mice showed only slight variability with respect to the studied biological parameters compared to the Ob/Ob mice group. Results indicated that following 4-weeks of diet supplementation, Ob/Ob mice fed diets A, C and D had significantly (p < 0.05) lower fasting blood glucose (FBG) than Ob/Ob mice fed Diet B. However, after 8-weeks Ob/Ob mice fed Diet C, containing YCr, had a significantly (p < 0.05) lower FBG than mice supplemented with Diet D, containing chromium picolinate. Therefore, based on these findings, it was concluded that YCr at the highest concentration and dose was more effective than chromium picolinate. These results indicate that ready-to-eat snacks and breakfast cereal type products supplemented with chromium in the form of YCr could be used as vehicles for the amelioration of main physiological factors associated with metabolic syndrome.
C1 [Attaran, Shireen; Yokoyama, Wallace; Pan, James; Berrios, Jose De J.] ARS, USDA, Western Reg Res Ctr, 800 Buchanan St, Albany, CA 94710 USA.
C3 United States Department of Agriculture (USDA)
RP Berrios, JD (corresponding author), ARS, USDA, Western Reg Res Ctr, 800 Buchanan St, Albany, CA 94710 USA.
EM jose.berrios@ars.usda.gov
CR A G. I. Garcia-Alonso, 2018, RESISTANT STARCH POT, DOI [10. 1007/s002170050258, DOI 10.1007/S002170050258]
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NR 27
TC 3
Z9 3
U1 0
U2 19
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PD OCT 1
PY 2018
VL 9
IS 10
BP 5238
EP 5244
DI 10.1039/c8fo00612a
PG 7
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA GX5IY
UT WOS:000447780400018
PM 30207351
DA 2025-06-11
ER

PT J
AU de la Iglesia, R
   Mansego, ML
   Sánchez-Muniz, FJ
   Zulet, MA
   Martinez, JA
AF de la Iglesia, Rocio
   Mansego, Maria L.
   Sanchez-Muniz, Francisco J.
   Angeles Zulet, M.
   Alfredo Martinez, J.
TI ARYLESTERASE ACTIVITY IS ASSOCIATED WITH ANTIOXIDANT INTAKE AND
   PARAOXONASE-1 (PON1) GENE METHYLATION IN METABOLIC
   SYNDROME PATIENTS FOLLOWING AN ENERGY RESTRICTED DIET
SO EXCLI JOURNAL
LA English
DT Article
DE DNA methylation; ARE; PON1 gene; obesity; metabolic syndrome; energy
   restriction; antioxidants
ID HIGH-DENSITY-LIPOPROTEIN; SERUM PARAOXONASE; OXIDATIVE STRESS; DNA
   METHYLATION; WEIGHT-LOSS; REDUCTION; HEALTH; OBESE; INTERVENTION;
   STRATEGY
AB The arylesterase (ARE) activity linked to the paraoxonase-1 (PON1) gene is known to protect lipoproteins from oxidation and provide defense against metabolic syndrome (MetS) and cardiovascular diseases. The epigenetic regulation of enzymatic activities is gaining importance nowadays. This research aimed to assess the potential relationships between the ARE activity with the methylation levels of the PON1 gene transcriptional regulatory region, anthropometrics, biochemical markers and antioxidant dietary components. Forty-seven subjects (47 +/- 10 y.o; BMI 36.2 +/- 3.8 kg/m(2); 46.8 % female) with MetS features, who followed a six-month energy-restricted dietary weight-loss intervention, were included in this study (www.clinicaltrials.gov; NCT01087086). Anthropometric, biochemical, enzymatic and dietary data were assessed using validated procedures. PON1 transcriptional regulatory region methylation was analyzed by a microarray technical approach. Volunteers reduced ARE activity in parallel with body weight (p = 0.005), BMI (p = 0.006), total fat mass (p = 0.020), diastolic blood pressure (p = 0.018), mean blood pressure (p = 0.022) and triglycerides (p = 0.014). Methylation levels of some CpG sites of the PON1 gene correlated negatively with ARE activity (p < 0.05). Interestingly, dietary vitamin C (p = 0.001), tocopherols (p = 0.009) and lycopene (p = 0.038) were positively associated with ARE activity and showed an inverse correlation (p = 0.004, p = 0.029 and p = 0.021, respectively) with the methylation of some selected CpG sites of the PON1 gene. In conclusion, ARE activity decreased in parallel with MetS-related markers associated to the energy restriction, while dietary antioxidants might enhance the ARE activity by lowering the PON1 gene methylation in patients with MetS features.
C1 [de la Iglesia, Rocio; Mansego, Maria L.; Angeles Zulet, M.; Alfredo Martinez, J.] Univ Navarra, Dept Nutr Food Sci & Physiol, Navarra 31008, Spain.
   [Mansego, Maria L.; Angeles Zulet, M.; Alfredo Martinez, J.] Carlos III Inst Hlth, CIBERobn, Madrid, Spain.
   [Sanchez-Muniz, Francisco J.] Univ Complutense Madrid, Dept Nutr & Bromatol Nutr 1, Madrid, Spain.
C3 University of Navarra; Instituto de Salud Carlos III; CIBER - Centro de
   Investigacion Biomedica en Red; CIBEROBN; Complutense University of
   Madrid
RP Martinez, JA (corresponding author), Univ Navarra, C Irunlarrea 1, Navarra 31008, Spain.
EM jalfmtz@unav.es
RI Zulet, M./H-1317-2017; de la Iglesia, Rocio/ABC-6189-2020; Martinez
   Hernandez, J Alfredo/K-8709-2014; MANSEGO, MARIA/A-5687-2011;
   Sanchez-Muniz, Francisco J/K-9795-2014
OI Martinez Hernandez, J Alfredo/0000-0001-5218-6941; MANSEGO,
   MARIA/0000-0001-8914-7890; Sanchez-Muniz, Francisco
   J/0000-0002-2660-5126; de la Iglesia, Rocio/0000-0002-7472-3565
FU Health Department of the Government of Navarra [48/2009]; Linea Especial
   about Nutrition, Obesity and Health (University of Navarra) [LE/97];
   Carlos III Health Institute [FI10/00587]; Spanish Ministry of Economic
   and Competitiveness
FX This work was supported by Health Department of the Government of
   Navarra (48/2009) and the Linea Especial about Nutrition, Obesity and
   Health (University of Navarra LE/97). Also CIBERobn and RETICS schemes
   from the isciii are gratefully credited. Carlos III Health Institute
   provided a predoctoral grant to R. de la Iglesia (no FI10/00587). M. L.
   M. holds a Juan de la Cierva fellowship from Spanish Ministry of
   Economic and Competitiveness.
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NR 48
TC 30
Z9 30
U1 0
U2 7
PU EXCLI JOURNAL MANAGING OFFICE
PI DORTMUND
PA LEIBNIZ RESEARCH CENTRE WORKING ENVIRONMENT & HUMAN FACTORS EXCLI
   JOURNAL, ARDEYSTR 67, DORTMUND, D-44139, GERMANY
SN 1611-2156
J9 EXCLI J
JI EXCLI J.
PY 2014
VL 13
BP 416
EP 426
PG 11
WC Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics
GA AG6HK
UT WOS:000335519500030
PM 26417268
DA 2025-06-11
ER

PT J
AU Beijers, HJBH
   Henry, RMA
   Bravenboer, B
   Ferreira, I
   Dekker, JM
   Nijpels, G
   Stehouwer, CDA
AF Beijers, Hanneke J. B. H.
   Henry, Ronald M. A.
   Bravenboer, Bert
   Ferreira, Isabel
   Dekker, Jacqueline M.
   Nijpels, Giel
   Stehouwer, Coen D. A.
TI Metabolic Syndrome in Nondiabetic Individuals Associated With
   Maladaptive Carotid Remodeling: The Hoorn Study
SO AMERICAN JOURNAL OF HYPERTENSION
LA English
DT Article
DE arterial remodeling; blood pressure; carotid artery; epidemiology;
   hypertension; metabolic syndrome; stroke
ID IMPAIRED GLUCOSE-METABOLISM; ARTERIAL STIFFNESS; BLOOD-PRESSURE;
   RISK-FACTORS; COMPENSATORY ENLARGEMENT; INSULIN RESISTANCE;
   ADIPOSE-TISSUE; PULSE PRESSURE; ATHEROSCLEROSIS; INFLAMMATION
AB BACKGROUND
   The metabolic syndrome (MetS) is associated with an increased risk of stroke. Arterial remodeling could play an important role herein as maladaptive remodeling is a risk factor for stroke. The purpose of this study was to investigate whether MetS was associated with maladaptive remodeling of the carotid artery and if any such association was independent of hemodynamic variables.
   METHODS
   We studied 385 (n = 195 women) nondiabetic, elderly subjects. A MetS z-score (average of sex-specific z-scores of the five MetS traits) was constructed. Intima-media thickness (IMT) and interadventitial diameter (IAD) were assessed by ultrasonography, and lumen diameter (LD), and circumferential wall stress (CWS) were calculated. Multiple linear regression analysis was used to investigate the association between MetS and carotid remodeling.
   RESULTS
   After adjustment for age, sex, height, prior cardiovascular disease (CVD), dyslipidemia, and smoking, MetS was independently associated with a greater IAD (regression coefficient (beta) per s.d. increase in MetS z-score (95% confidence interval), 0.45 mm (0.28; 0.63)), LD (0.41 mm (0.25; 0.58)) and CWS (5.56 kPa (3.71; 7.42)). These associations were attenuated after additional adjustment for inflammatory, metabolic and particularly hemodynamic variables, but remained statistically significant. No significant association was found between MetS and IMT (0.020 mm (-0.006; 0.046)).
   CONCLUSIONS
   MetS is associated with maladaptive remodeling of the carotid artery, which is the result of changes in LD, IAD, and, to a lesser extent, IMT. This process is independent of hemodynamic variables. Whether this association and process will be observed in a broader population and explains the increased risk of stroke in MetS deserves further study.
C1 [Beijers, Hanneke J. B. H.; Bravenboer, Bert] Catharina Hosp, Dept Med, Eindhoven, Netherlands.
   [Henry, Ronald M. A.; Ferreira, Isabel; Stehouwer, Coen D. A.] Maastricht Univ, Med Ctr, Dept Med, Maastricht, Netherlands.
   [Ferreira, Isabel] Maastricht Univ, Med Ctr, Dept Clin Epidemiol & Med Technol Assessment, Maastricht, Netherlands.
   [Ferreira, Isabel; Stehouwer, Coen D. A.] Maastricht Univ, Med Ctr, Cardiovasc Res Inst Maastricht, Maastricht, Netherlands.
   [Ferreira, Isabel] Maastricht Univ, Med Ctr, Care & Publ Hlth Res Inst, Maastricht, Netherlands.
   [Dekker, Jacqueline M.; Nijpels, Giel] Vrije Univ Amsterdam Med Ctr, EMGO Inst Hlth & Care Res, Amsterdam, Netherlands.
C3 Catharina Hospital; Maastricht University; Maastricht University;
   Maastricht University; Maastricht University; Maastricht University
   Medical Centre (MUMC); Vrije Universiteit Amsterdam; VU UNIVERSITY
   MEDICAL CENTER
RP Beijers, HJBH (corresponding author), Catharina Hosp, Dept Med, Eindhoven, Netherlands.
EM hanneke.beijers@catharina-ziekenhuis.nl
RI Stehouwer, Coen/AAB-3435-2021; Ferreira de Sousa, Maria
   Isabel/B-6033-2008
OI Stehouwer, Coen/0000-0001-8752-3223; Ferreira de Sousa, Maria
   Isabel/0000-0003-1434-0607
FU Dutch Heart Foundation (NHS) [2006T050]
FX I.F. is supported by a research grant from the Dutch Heart Foundation
   (NHS; grant #2006T050).
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NR 39
TC 10
Z9 12
U1 0
U2 4
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0895-7061
EI 1941-7225
J9 AM J HYPERTENS
JI Am. J. Hypertens.
PD APR
PY 2011
VL 24
IS 4
BP 429
EP 436
DI 10.1038/ajh.2010.256
PG 8
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 740VT
UT WOS:000288823200014
PM 21212746
OA Bronze
DA 2025-06-11
ER

PT J
AU Hajjar, DP
   Gotto, AM
AF Hajjar, David P.
   Gotto, Antonio M., Jr.
TI Biological Relevance of Inflammation and Oxidative Stress in the
   Pathogenesis of Arterial Diseases
SO AMERICAN JOURNAL OF PATHOLOGY
LA English
DT Review
ID CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; OXIDIZED PHOSPHOLIPIDS;
   BINDING PROTEINS; ADIPOSE-TISSUE; HEART-DISEASE; OBESITY;
   ATHEROSCLEROSIS; LIPOPROTEIN; CHEMOKINES
AB Over the past three decades, age-adjusted rates of cardiovascular morbidity and mortality have fallen in the United States, but the prevalence of obesity and associated metabolic disorders has risen dramatically. Recent studies have begun to unravel the complex Linkages between adipose and vascular tissues that may accelerate the development of atherosclerosis in the context of obesity. Experimental models indicate that inflammation and oxidative stress, which mutually amplify each other within the vasculature and in visceral fat, are key processes that drive the initiation, progression, and subsequent rupture of the atherosclerotic lesion. Emerging research is further elucidating the contributions made by chemokines and their receptors, adipokines, and miRNAs to arterial disease. Translation of these basic science findings to clinical applications represents a tantalizing possibility for reducing the global burden of obesity-associated atherosclerosis and other cardiovascular diseases.
C1 [Hajjar, David P.] Cornell Univ, Weill Cornell Med Coll, Dept Biochem, New York, NY 10065 USA.
   [Hajjar, David P.] Cornell Univ, Weill Cornell Med Coll, Dept Pathol & Lab Med, New York, NY 10065 USA.
   [Gotto, Antonio M., Jr.] Cornell Univ, Weill Cornell Med Coll, Dept Med, New York, NY 10065 USA.
C3 Cornell University; Weill Cornell Medicine; Cornell University; Weill
   Cornell Medicine; Cornell University; Weill Cornell Medicine
RP Hajjar, DP (corresponding author), Cornell Univ, Weill Cornell Med Coll, 1300 York Ave, New York, NY 10065 USA.
EM dphajjar@med.cornell.edu
FU NIH [P01 HL-46403, R01 HL-091101]; Julia & Seymour Gross Foundation
FX Supported by the NIH grants P01 HL-46403 and R01 HL-091101 and the Julia
   & Seymour Gross Foundation (D.P.H.).
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NR 51
TC 136
Z9 149
U1 0
U2 24
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0002-9440
EI 1525-2191
J9 AM J PATHOL
JI Am. J. Pathol.
PD MAY
PY 2013
VL 182
IS 5
BP 1474
EP 1481
DI 10.1016/j.ajpath.2013.01.010
PG 8
WC Pathology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pathology
GA 138TY
UT WOS:000318534100002
PM 23608224
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Pardo, PS
   Boriek, AM
AF Pardo, Patricia S.
   Boriek, Aladin M.
TI SIRT1 Regulation in Ageing and Obesity
SO MECHANISMS OF AGEING AND DEVELOPMENT
LA English
DT Review
DE Ageing; Obesity; SIRT1
ID HYPOXIA-INDUCIBLE FACTORS; FATTY-ACID OXIDATION; CALORIE RESTRICTION;
   LIFE-SPAN; SKELETAL-MUSCLE; ADIPOSE-TISSUE; DNA-DAMAGE; NICOTINAMIDE
   PHOSPHORIBOSYLTRANSFERASE; RESVERATROL SUPPLEMENTATION; MITOCHONDRIAL
   BIOGENESIS
AB Ageing and obesity have common hallmarks: altered glucose and lipid metabolism, chronic inflammation and oxidative stress are some examples. The downstream effects of SIRT1 activity have been thoroughly explored, and their research is still in expanse. SIRT1 activation has been shown to regulate pathways with beneficiary effects on 1) ageing and obesity-associated metabolic disorders such as metabolic syndrome, insulin resistance and type-II diabetes with, 2) chronic inflammatory processes such as arthritis, atherosclerosis and emphysema, 3) DNA damage and oxidative stress with impact on neurodegenerative diseases, cardiovascular health and some cancers. This knowledge intensified the interest in uncovering the mechanisms regulating the expression and activity of SIRT1. This review focuses on the upstream regulatory mechanisms controlling SIRT1, and how this knowledge could potentially contribute to the development of therapeutic interventions.
C1 [Pardo, Patricia S.; Boriek, Aladin M.] Baylor Coll Med, Dept Med, Pulm & Crit Care Med, Houston, TX 77030 USA.
C3 Baylor College of Medicine
RP Pardo, PS; Boriek, AM (corresponding author), Baylor Coll Med, Dept Med, Pulm & Crit Care Med, Houston, TX 77030 USA.
EM pardopatricia@gmail.com; boriek@bcm.edu
FU National Science Foundation
FX This work was supported by the National Science Foundation. The authors
   apologize in advance to those researchers who contributed to the field
   and their publications were not listed in this review.
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NR 208
TC 54
Z9 55
U1 4
U2 36
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0047-6374
EI 1872-6216
J9 MECH AGEING DEV
JI Mech. Ageing Dev.
PD JUN
PY 2020
VL 188
AR 111249
DI 10.1016/j.mad.2020.111249
PG 15
WC Cell Biology; Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Geriatrics & Gerontology
GA LT9TY
UT WOS:000537409200007
PM 32320732
DA 2025-06-11
ER

PT J
AU Cincotta, AH
AF Cincotta, Anthony H.
TI Brain Dopamine-Clock Interactions Regulate Cardiometabolic Physiology:
   Mechanisms of the Observed Cardioprotective Effects of Circadian-Timed
   Bromocriptine-QR Therapy in Type 2 Diabetes Subjects
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE bromocriptine; dopamine; diabetes; circadian; Cycloset; neuroendocrine;
   suprachiasmatic nucleus; cardiovascular; metabolic syndrome
ID SYMPATHETIC-NERVOUS-SYSTEM; PITUITARY-ADRENAL-AXIS; FREE FATTY-ACID;
   CORTICOTROPIN-RELEASING HORMONE; INDUCED INSULIN-RESISTANCE;
   SUPRACHIASMATIC NUCLEUS CONTROLS; HYPOTHALAMIC NEUROPEPTIDE-Y;
   GLUCOSE-SENSING NEURONS; D2 RECEPTORS ACTIVATION; WHITE ADIPOSE-TISSUE
AB Despite enormous global efforts within clinical research and medical practice to reduce cardiovascular disease(s) (CVD), it still remains the leading cause of death worldwide. While genetic factors clearly contribute to CVD etiology, the preponderance of epidemiological data indicate that a major common denominator among diverse ethnic populations from around the world contributing to CVD is the composite of Western lifestyle cofactors, particularly Western diets (high saturated fat/simple sugar [particularly high fructose and sucrose and to a lesser extent glucose] diets), psychosocial stress, depression, and altered sleep/wake architecture. Such Western lifestyle cofactors are potent drivers for the increased risk of metabolic syndrome and its attendant downstream CVD. The central nervous system (CNS) evolved to respond to and anticipate changes in the external (and internal) environment to adapt survival mechanisms to perceived stresses (challenges to normal biological function), including the aforementioned Western lifestyle cofactors. Within the CNS of vertebrates in the wild, the biological clock circuitry surveils the environment and has evolved mechanisms for the induction of the obese, insulin-resistant state as a survival mechanism against an anticipated ensuing season of low/no food availability. The peripheral tissues utilize fat as an energy source under muscle insulin resistance, while increased hepatic insulin resistance more readily supplies glucose to the brain. This neural clock function also orchestrates the reversal of the obese, insulin-resistant condition when the low food availability season ends. The circadian neural network that produces these seasonal shifts in metabolism is also responsive to Western lifestyle stressors that drive the CNS clock into survival mode. A major component of this natural or Western lifestyle stressor-induced CNS clock neurophysiological shift potentiating the obese, insulin-resistant state is a diminution of the circadian peak of dopaminergic input activity to the pacemaker clock center, suprachiasmatic nucleus. Pharmacologically preventing this loss of circadian peak dopaminergic activity both prevents and reverses existing metabolic syndrome in a wide variety of animal models of the disorder, including high fat-fed animals. Clinically, across a variety of different study designs, circadian-timed bromocriptine-QR (quick release) (a unique formulation of micronized bromocriptine-a dopamine D2 receptor agonist) therapy of type 2 diabetes subjects improved hyperglycemia, hyperlipidemia, hypertension, immune sterile inflammation, and/or adverse cardiovascular event rate. The present review details the seminal circadian science investigations delineating important roles for CNS circadian peak dopaminergic activity in the regulation of peripheral fuel metabolism and cardiovascular biology and also summarizes the clinical study findings of bromocriptine-QR therapy on cardiometabolic outcomes in type 2 diabetes subjects.
C1 [Cincotta, Anthony H.] VeroSci LLC, Tiverton, RI 02878 USA.
RP Cincotta, AH (corresponding author), VeroSci LLC, Tiverton, RI 02878 USA.
EM anthony_cincotta@veroscience.com
FU I gratefully acknowledge the excellent mentorship and research
   accomplishments of Albert H. Meier in the genesis of the findings
   related to the cardiometabolic effects of circadian-timed
   bromocriptine-QR therapy described in this review.
FX I gratefully acknowledge the excellent mentorship and research
   accomplishments of Albert H. Meier in the genesis of the findings
   related to the cardiometabolic effects of circadian-timed
   bromocriptine-QR therapy described in this review.
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NR 510
TC 6
Z9 6
U1 2
U2 5
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD SEP
PY 2023
VL 24
IS 17
AR 13255
DI 10.3390/ijms241713255
PG 48
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA Q9LB2
UT WOS:001060648000001
PM 37686060
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Scott, NJA
   Ellmers, LJ
   Pilbrow, AP
   Thomsen, L
   Richards, AM
   Frampton, CM
   Cameron, VA
AF Scott, Nicola J. A.
   Ellmers, Leigh J.
   Pilbrow, Anna P.
   Thomsen, Lotte
   Richards, Arthur Mark
   Frampton, Chris M.
   Cameron, Vicky A.
TI Metabolic and Blood Pressure Effects of Walnut Supplementation in a
   Mouse Model of the Metabolic Syndrome
SO NUTRIENTS
LA English
DT Article
DE metabolic syndrome; walnuts; glucose tolerance; cholesterol; gene
   expression
ID CARDIOVASCULAR RISK-FACTORS; HYPERCHOLESTEROLEMIC MEN; INFLAMMATORY
   MARKERS; ENDOTHELIAL FUNCTION; INSULIN-RESISTANCE; LIPID PROFILE;
   CONSUMPTION; DIETARY; FAT; NUTS
AB There is extensive evidence that walnut consumption is protective against cardiovascular disease and diabetes in the healthy population, but the beneficial effects of walnut consumption in individuals with the metabolic syndrome (MetS) remain uncertain. We compared a range of cardio-metabolic traits and related tissue gene expression associated with 21 weeks of dietary walnut supplementation in a mouse model of MetS (MetS-Tg) and wild-type (WT) mice (n = 10 per genotype per diet, equal males and females). Compared to standard diet, walnuts did not significantly alter food consumption or body weight trajectory of either MetS-Tg or WT mice. In MetS-Tg mice, walnuts were associated with reductions in oral glucose area under the curve (gAUC, standard diet 1455 +/- 54, walnut 1146 +/- 91, p = 0.006) and mean arterial blood pressure (MAP, standard diet 100.6 +/- 1.9, walnut 73.2 +/- 1.8 mmHg, p < 0.001), with neutral effects on gAUC and MAP in WT mice. However, in MetS-Tg mice, walnuts were also associated with trends for higher plasma cholesterol (standard diet 4.73 +/- 0.18, walnut 7.03 +/- 1.99 mmol/L, p = 0.140) and triglyceride levels (standard diet 2.4 +/- 0.5, walnut 5.4 +/- 1.6 mmol/L, p = 0.061), despite lowering cholesterol and having no effect on triglycerides in WT mice. Moreover, in both MetS-Tg and WT mice, walnuts were associated with significantly increased liver expression of genes associated with metabolism (Fabp1, Insr), cell stress (Atf6, Ddit3, Eif2ak3), fibrosis (Hgf, Sp1, Timp1) and inflammation (Tnf, Ptpn22, Pparg). In conclusion, dietary walnuts were associated with modest favourable effects in WT mice, but a combination of beneficial and adverse effects in MetS-Tg mice, and up-regulation of hepatic pro-fibrotic and pro-inflammatory genes in both mouse strains.
C1 [Scott, Nicola J. A.; Ellmers, Leigh J.; Pilbrow, Anna P.; Thomsen, Lotte; Richards, Arthur Mark; Frampton, Chris M.; Cameron, Vicky A.] Univ Otago Christchurch, Christchurch Heart Inst, POB 4345, Christchurch 8140, New Zealand.
   [Richards, Arthur Mark] Natl Univ Singapore, Cardiovasc Res Inst, 1E Kent Ridge Rd, Singapore 119228, Singapore.
C3 University of Otago; National University of Singapore
RP Cameron, VA (corresponding author), Univ Otago Christchurch, Christchurch Heart Inst, POB 4345, Christchurch 8140, New Zealand.
EM nicola.scott@otago.ac.nz; Leigh.ellmers@otago.ac.nz;
   anna.pilbrow@otago.ac.nz; lottekthomsen@icloud.com;
   arthur_mark_richards@nuhs.edu.sg; Statistecol@xtra.co.nz;
   vicky.cameron@otago.ac.nz
RI Cameron, Vicky/L-4046-2019; Scott, Nicola/AAG-8318-2019; Richards,
   Mark/AGQ-8244-2022
OI Cameron, Vicky/0000-0003-3147-683X; Richards, Mark/0000-0002-2023-8177;
   Scott, Nicola/0000-0002-5685-9151
FU Heart Foundation of New Zealand; Canterbury Medical Research Foundation;
   Lotteries Health New Zealand; Maurice and Phyllis Paykel Trust; Health
   Research Council of New Zealand
FX Supported by grants from the Heart Foundation of New Zealand, Canterbury
   Medical Research Foundation, Lotteries Health New Zealand, Maurice and
   Phyllis Paykel Trust and the Health Research Council of New Zealand. We
   are very grateful to Professor Evan Simpson, (Hudson Institute of
   Medical Research, Victoria, Australia) for supply of the aromatase
   knockout (ARKO) mice. We are also grateful to the animal laboratory
   staff of the University of Otago-Christchurch, for animal care.
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NR 43
TC 12
Z9 14
U1 0
U2 5
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JUL
PY 2017
VL 9
IS 7
AR 722
DI 10.3390/nu9070722
PG 14
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA FC2PF
UT WOS:000406679700079
PM 28686204
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Beltowski, J
   Wójcicka, G
   Jamroz-Wisniewska, A
   Marciniak, A
AF Beltowski, Jerzy
   Wojcicka, Grazyna
   Jamroz-Wisniewska, Anna
   Marciniak, Andrzej
TI Resistance to acute NO-mimetic and EDHF-mimetic effects of leptin in the
   metabolic syndrome
SO LIFE SCIENCES
LA English
DT Article
DE Leptin; Nitric oxide; Endothelium-derived hyperpolarizing factor;
   Arterial hypertension; Obesity; Insulin resistance
ID SPONTANEOUSLY HYPERTENSIVE-RATS; II-INDUCED VASOCONSTRICTION;
   INSULIN-SIGNALING PATHWAYS; NITRIC-OXIDE PRODUCTION; ENDOTHELIAL-CELLS;
   BLOOD-PRESSURE; CARDIOVASCULAR-DISEASE; HYPERPOLARIZING FACTOR;
   OXIDATIVE STRESS; VASCULAR-TONE
AB Aims: We examined mechanisms leading to the impairment of nitric oxide (NO) and endothelium-derived hyperpolarizing factor (EDHF)-dependent vasorelaxation in response to acutely administered leptin in rats with the metabolic syndrome.
   Main methods: Effects of leptin on blood pressure and NO and cGMP in the aortic wall were studied in four groups of rats: (1) lean control, (2) obese, fed "cafeteria diet" for 3 months (hyperleptinemia and hyperinsulinemia), (3) hyperleptinemia induced by administration of exogenous leptin for 8 days, and (4) fructose-fed, receiving 20% fructose in the drinking water for 8 weeks (hyperinsulinemia with slightly elevated leptin).
   Keyfindings: Stimulatory effect of leptin on NO and cGMP production in the aortic wall was impaired in obese and hyperleptinemic groups but not in the fructose group. In contrast, EDHF-mimetic effect of leptin was impaired in obese and fructose-fed but not in the hyperleptinemic group. Leptin increased tyrosine phosphorylation of insulin receptor substrate-1 (IRS-1) in the aortic wall, and this effect was impaired in obese and fructose-fed animals. The EDHF-mimetic effect of leptin was abolished by phosphoinositide 3-kinase inhibitor. wortmannin, whereas its effect on NO was not. In addition, IRS-1 phosphorylation at Ser(307) and Set(612) was enhanced in obese and fructose-fed but not in hyperleptinemic rats.
   Significance: These results indicate that: (1) long-term hyperleptinemia induces resistance to acute vascular NO-mimetic effect of leptin in obesity/metabolic syndrome, (2) leptin stimulates EDHF in IRS-1 and PI3K-dependent manner, and this effect is impaired in obesity due to excessive serine phosphorylation of IRS-1. (C) 2009 Elsevier Inc. All rights reserved.
C1 [Beltowski, Jerzy; Wojcicka, Grazyna; Jamroz-Wisniewska, Anna; Marciniak, Andrzej] Med Univ, Dept Pathophysiol, PL-20090 Lublin, Poland.
C3 Medical University of Lublin
RP Beltowski, J (corresponding author), Med Univ, Dept Pathophysiol, Ul Jaczewskiego 8, PL-20090 Lublin, Poland.
EM jerzy.beltowski@am.lublin.pl
RI Beltowski, Jerzy/AAH-4692-2020
OI Wojcicka, Grazyna/0000-0002-1822-5027; Beltowski,
   Jerzy/0000-0001-7903-8121
FU Medical University in Lublin [DS 476]
FX This study was supported by the grant DS 476 from Medical University in
   Lublin.
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NR 52
TC 28
Z9 29
U1 0
U2 4
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0024-3205
EI 1879-0631
J9 LIFE SCI
JI Life Sci.
PD OCT 7
PY 2009
VL 85
IS 15-16
BP 557
EP 567
DI 10.1016/j.lfs.2009.08.002
PG 11
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA 506SX
UT WOS:000270797600002
PM 19686764
DA 2025-06-11
ER

PT J
AU Muñoz-Ruiz, MA
   González-Zapata, LI
   Abril-Ulloa, V
   Gaitán-Charry, DA
AF Munoz-Ruiz, Melisa A.
   Gonzalez-Zapata, Laura I.
   Abril-Ulloa, Victoria
   Gaitan-Charry, Diego A.
TI Metabolic syndrome may be associated with a lower prevalence of iron
   deficiency in Ecuadorian women of reproductive age
SO JOURNAL OF NUTRITIONAL SCIENCE
LA English
DT Article
DE Metabolic syndrome; Iron deficiency; Iron-deficiency anaemia; Women
ID PROCESSED FOOD-PRODUCTS; OXIDATIVE STRESS; HEALTH OUTCOMES; GLYCEMIC
   INDEX; ANEMIA; OBESITY; CAPACITY; AMERICA; LIVER; RISK
AB The present study aimed to assess the associations of the stages of Fe deficiency (Fe deficiency without anaemia (ID) and Fe-deficiency anaemia (IDA)) and anaemia with metabolic syndrome (MetS) in Ecuadorian women. A cross-sectional study was conducted in 5894 women aged 20-59 years, based on data from the 2012 Ecuadorian National Health and Nutrition Survey. The sample was stratified by age. A chi(2) test was used to assess the possible associations of ID, IDA and anaemia with MetS. The prevalence ratio (PR) for each stage of Fe deficiency and anaemia was estimated considering women without MetS as a reference. The total prevalence of MetS, ID, IDA and anaemia was 32.3 % (se 0.6), 6.2 % (se 0.3), 7.1 % (se 0.3) and 5.0 % (se 0.3), respectively. In women aged 20-29, 30-39 and 40-49 years, MetS was associated with a lower prevalence of ID (PR (95 % CI; P-value)): 0.17 (0.06, 0.46; P < 0.001), 0.69 (0.48, 0.99; P = 0.044) and 0.44 (0.29, 0.67; P < 0.001), respectively. In women aged 50-59 years, MetS was associated with IDA and anaemia (PR (95 % CI; P-value)): 0.12 (0.02, 0.96; P = 0.026) and 0.22 (0.07, 0.64; P = 0.002), respectively. In conclusion, Ecuadorian women of reproductive age with MetS have a lower prevalence of ID compared with those without MetS. Furthermore, the MetS and IDA coexist at the population level. These findings require an analysis from a dietary pattern approach, which could provide key elements for developing public policies that simultaneously address all forms of malnutrition.
C1 [Munoz-Ruiz, Melisa A.; Gonzalez-Zapata, Laura I.; Gaitan-Charry, Diego A.] Univ Antioquia UdeA, Escuela Nutr & Dietet, Unidad Problemat Interes Nutr Publ, Calle 70 52-21, Medellin, Colombia.
   [Gonzalez-Zapata, Laura I.] Univ Antioquia UdeA, Escuela Nutr & Dietet, Grp Invest Determinantes Sociales & Econ Situac S, Calle 70 52-21, Medellin, Colombia.
   [Abril-Ulloa, Victoria] Univ Cuenca, Fac Ciencias Med, Grp Invest Salud Publ Alimentac & Actividad Fis C, Carrera Nutr & Dietet, Cuenca, Ecuador.
   [Abril-Ulloa, Victoria] Univ Cuenca, Direcc Invest, Cuenca, Ecuador.
C3 Universidad de Antioquia; Universidad de Antioquia; Universidad de
   Cuenca; Universidad de Cuenca
RP Gaitán-Charry, DA (corresponding author), Univ Antioquia UdeA, Escuela Nutr & Dietet, Unidad Problemat Interes Nutr Publ, Calle 70 52-21, Medellin, Colombia.
RI Abril, Victoria/AAH-2702-2020; González-Zapata, Laura/P-1684-2018
OI Munoz Ruiz, Melisa Alejandra/0000-0001-5415-3166; Abril-Ulloa,
   Victoria/0000-0002-4083-8401
FU research group 'Determinantes Sociales y Economicos de la Situacion de
   Salud y Nutricion' [20260002/1033/2018]; Sustainability Strategy of the
   School of Nutrition and Dietetics from the University of Antioquia;
   School of Nutrition and Dietetics from the University of Antioquia;
   'Facultad de Ciencias Medicas' from the University of Cuenca [CODI
   2019-26350]; 'Direccion de Investigacion' from the University of Cuenca
   [CODI 2019-26350]; research group 'Determinantes Sociales y Economicos
   de la Situacion de Salud y Nutricion' from the University of Antioquia;
   'Direccion de Investigacion' from the University of Cuenca
FX The main author received financial support from the research group
   'Determinantes Sociales y Economicos de la Situacion de Salud y
   Nutricion' (M. A. M.-R., grant number 20260002/1033/2018) and from the
   Sustainability Strategy of the School of Nutrition and Dietetics from
   the University of Antioquia. D. A. G.-C. and L. I. G.-Z. were supported
   by the School of Nutrition and Dietetics from the University of
   Antioquia, and V. A.-U. was supported by the 'Facultad de Ciencias
   Medicas' and the 'Direccion de Investigacion' from the University of
   Cuenca in the context of the research project 'Doble Carga de
   Malnutricion y Sindrome Metabolico en individuos ecuatorianos entre 10 y
   59 anos' (project number CODI 2019-26350). The publication of this paper
   was supported by the research group 'Determinantes Sociales y Economicos
   de la Situacion de Salud y Nutricion' from the University of Antioquia
   and by the 'Direccion de Investigacion' from the University of Cuenca.
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NR 55
TC 1
Z9 1
U1 1
U2 8
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
EI 2048-6790
J9 J NUTR SCI
JI J. Nutr. Sci.
PD JAN 12
PY 2021
VL 10
AR e4
DI 10.1017/jns.2020.55
PG 7
WC Nutrition & Dietetics
WE Emerging Sources Citation Index (ESCI)
SC Nutrition & Dietetics
GA PR3FQ
UT WOS:000607125300001
PM 33889387
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Roos, V
   Elmståhl, S
   Ingelsson, E
   Sundström, J
   Ärnlöv, J
   Lind, L
AF Roos, Vendela
   Elmstahl, Solve
   Ingelsson, Erik
   Sundstrom, Johan
   Arnlov, Johan
   Lind, Lars
TI Alterations in Multiple Lifestyle Factors in Subjects with the Metabolic
   Syndrome Independently of Obesity
SO METABOLIC SYNDROME AND RELATED DISORDERS
LA English
DT Article
DE metabolic syndrome; obesity; lifestyle factors; MHO
ID QUALITY-OF-LIFE; PHYSICAL-ACTIVITY; RISK-FACTORS; ALCOHOL-CONSUMPTION;
   HEALTHY OBESE; NORMAL-WEIGHT; PREVALENCE; ASSOCIATION; METAANALYSIS;
   PHENOTYPES
AB Background: Many lifestyle factors have been associated with the metabolic syndrome (MetS). However, most of these studies have not considered the potential impact of obesity and have often only investigated one lifestyle factor at the time. We aimed to investigate the interplay between body mass index (BMI) and MetS with respect to multiple lifestyle factors.
   Methods: BMI and MetS [National Cholesterol Education Program (NCEP)/Adult Treatment Panel III criteria] were assessed in a sample of 18,880 subjects aged 45-75 years from the population-based EpiHealth study. Participants were categorized into six groups according to BMI category (normal weight/BMI <25 kg/m(2), overweight/BMI 25-30 kg/m(2), and obesity/BMI > 30 kg/m(2)) and MetS status (+/-, NCEP criteria). A wide range of lifestyle factors related to physical activity, smoking, alcohol, sleep quality, working conditions, quality of life and stress, and eating patterns were assessed using a questionnaire.
   Results: Prevalent MetS (23% in the sample) was associated with less physical activity (P < 0.0001), more TV watching (P < 0.0001), more years of smoking (P < 0.0001), lower education level (P = 0.007), and experiencing a poor general quality of life (P < 0.0001). These lifestyle factors were all associated with MetS, independently of each other and independently of BMI. Similar results were generated when number of MetS components and presence/absence of individual MetS components were used as outcomes.
   Conclusions: This cross-sectional study identified alterations in a number of lifestyle factors associated with MetS independently of each other and independently of BMI. Future longitudinal studies are needed to assess causal and temporal relationships between lifestyle factors and MetS development.
C1 [Roos, Vendela; Sundstrom, Johan; Arnlov, Johan; Lind, Lars] Uppsala Univ, Univ Uppsala Hosp, Dept Med Sci, S-75185 Uppsala, Sweden.
   [Elmstahl, Solve] Lund Univ, Malmo Univ Hosp, Dept Hlth Sci, Div Geriatr Med, Malmo, Sweden.
   [Ingelsson, Erik] Stanford Univ, Sch Med, Dept Med, Div Cardiovasc Med, Stanford, CA 94305 USA.
   [Ingelsson, Erik] Uppsala Univ, Dept Med Sci, Mol Epidemiol & Sci Life Lab, Uppsala, Sweden.
   [Sundstrom, Johan] Uppsala Clin Res Ctr UCR, Uppsala, Sweden.
   [Arnlov, Johan] Dalarna Univ, Sch Hlth & Social Studies, Falun, Sweden.
C3 Uppsala University; Uppsala University Hospital; Lund University; Skane
   University Hospital; Stanford University; Uppsala University; Dalarna
   University
RP Lind, L (corresponding author), Uppsala Univ, Univ Uppsala Hosp, Dept Med Sci, S-75185 Uppsala, Sweden.
EM lars.lind@medsci.uu.se
RI Sundström, Johan/IAP-6197-2023; Lind, Lars/KAM-1968-2024; ärnlöv,
   Johan/AAF-2746-2019
OI Arnlov, Johan/0000-0002-6933-4637; Sundstrom, Johan/0000-0003-2247-8454
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NR 38
TC 8
Z9 8
U1 0
U2 5
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-4196
EI 1557-8518
J9 METAB SYNDR RELAT D
JI Metab. Syndr. Relat. Disord.
PD APR
PY 2017
VL 15
IS 3
BP 118
EP 123
DI 10.1089/met.2016.0120
PG 6
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA EP7VO
UT WOS:000397585500003
PM 28339343
DA 2025-06-11
ER

PT J
AU Dullaart, RPF
   de Boer, JF
   Annema, W
   Tietge, UJF
AF Dullaart, Robin P. F.
   de Boer, Jan Freark
   Annema, Wijtske
   Tietge, Uwe J. F.
TI The Inverse Relation of HDL Anti-Oxidative Functionality with Serum
   Amyloid a is Lost in Metabolic Syndrome Subjects
SO OBESITY
LA English
DT Article
ID HIGH-DENSITY-LIPOPROTEIN; C-REACTIVE PROTEIN; REVERSE CHOLESTEROL
   TRANSPORT; ELEVATED OXIDATIVE STRESS; TYPE-2 DIABETES-MELLITUS;
   CORONARY-ARTERY-DISEASE; LOW-GRADE INFLAMMATION; APOLIPOPROTEIN-A-I;
   PHOSPHOLIPASE A(2); CARDIOVASCULAR-DISEASE
AB Objective: Anti-oxidative properties of high density lipoproteins (HDL) are relevant for atheroprotection. HDL carry serum amyloid A (SAA), which may impair HDL functionality. We questioned whether HDL anti-oxidative capacity is determined by SAA.
   Design and Methods: Relationships of HDL anti-oxidative capacity (% inhibition of low density lipoprotein oxidation in vitro) with SAA were determined in 54 non-diabetic subjects without metabolic syndrome (MetS) and 68 subjects with MetS (including 51 subjects with Type 2 diabetes mellitus).
   Results: SAA levels were higher in MetS subjects, coinciding higher high sensitive C-reactive protein (hs-CRP) and lower HDL cholesterol and apolipoprotein (apo) A-I levels (P<0.001 for all). HDL anti-oxidative capacity was not different between subjects with and without MetS (P=0.76), but the HDL anti-oxidation index (HDL anti-oxidative capacity multiplied by individual HDL cholesterol concentrations), as a measure of global anti-oxidative functionality of HDL, was lower in Mets subjects (P<0.001). HDL anti-oxidative capacity was correlated inversely with SAA levels in subjects without MetS (r=-0.286, P=0.036). Notably, this relationship was independent of HDL cholesterol or apoA-I (P<0.05 for both). In contrast, no relation of HDL anti-oxidative capacity with SAA was observed in MetS subjects (r=0.032, P=0.80). The relationship of SAA with HDL anti-oxidative capacity was different in subjects with MetS compared to subjects without MetS (P=0.039 for the interaction between the presence of MetS and SAA on HDL anti-oxidative capacity) taking age and diabetes status into account.
   Conclusion: Higher SAA levels may impair HDL anti-oxidative functionality. The relationship of this physiologically relevant HDL functionality measure with circulating SAA levels is apparently disturbed in metabolic syndrome.
C1 [Dullaart, Robin P. F.] Univ Groningen, Univ Med Ctr Groningen, Ctr Liver Digest & Metab Dis, Dept Endocrinol, NL-9713 AV Groningen, Netherlands.
   [Dullaart, Robin P. F.; de Boer, Jan Freark; Annema, Wijtske; Tietge, Uwe J. F.] Univ Groningen, Univ Med Ctr Groningen, Groningen, Netherlands.
   [de Boer, Jan Freark; Annema, Wijtske; Tietge, Uwe J. F.] Univ Groningen, Univ Med Ctr Groningen, Ctr Liver Digest & Metab Dis, Dept Pediat, NL-9713 AV Groningen, Netherlands.
   [Annema, Wijtske; Tietge, Uwe J. F.] Top Inst Food & Nutr, Wageningen, Netherlands.
C3 University of Groningen; University of Groningen; University of
   Groningen; Top Institute Food & Nutrition
RP Dullaart, RPF (corresponding author), Univ Groningen, Univ Med Ctr Groningen, Ctr Liver Digest & Metab Dis, Dept Endocrinol, NL-9713 AV Groningen, Netherlands.
EM r.p.f.dullaart@int.umcg.nl
FU Dutch Diabetes Research Foundation [2001.00.012]; Top Institute (TI)
   Food and Nutrition; Groningen Expert Center for Kids with Obesity
FX R.P.F. Dullaart, MD, PhD, is supported by the Dutch Diabetes Research
   Foundation, grant 2001.00.012. U.J.F. Tietge, MD, PhD, is supported by
   grants from the Top Institute (TI) Food and Nutrition and the Groningen
   Expert Center for Kids with Obesity.
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NR 39
TC 26
Z9 26
U1 0
U2 3
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1930-7381
J9 OBESITY
JI Obesity
PD FEB
PY 2013
VL 21
IS 2
BP 361
EP 366
DI 10.1002/oby.20058
PG 6
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 187AH
UT WOS:000322087300021
PM 23404653
OA Bronze
DA 2025-06-11
ER

PT J
AU Zhao, YS
   Chen, B
   Shen, J
   Wan, L
   Zhu, YX
   Yi, T
   Xiao, ZG
AF Zhao, Yueshui
   Chen, Bo
   Shen, Jing
   Wan, Lin
   Zhu, Yinxin
   Yi, Tao
   Xiao, Zhangang
TI The Beneficial Effects of Quercetin, Curcumin, and Resveratrol in
   Obesity
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Review
ID BROWN ADIPOSE-TISSUE; ACTIVATED RECEPTOR-GAMMA; ONION PEEL EXTRACT;
   HIGH-FAT; OXIDATIVE STRESS; METABOLIC SYNDROME; ENERGY-EXPENDITURE;
   LIPOPROTEIN-LIPASE; GENE-EXPRESSION; COLD-EXPOSURE
AB Over the past two decades, obesity has been one of the major public health concerns in most countries. In the search for new molecules that could be used for the treatment of obesity, good perspectives have been opened up for polyphenols, a class of natural bioactive phytochemicals. Experimental and limited clinical trial evidence supports that some polyphenols such as quercetin, curcumin, and resveratrol have potential benefit functions on obesity treatment. This brief review focuses on the main functions of the above-named polyphenols on adipose tissue. These polyphenols may play beneficial effects on adipose tissue under obese condition by alleviating intracellular oxidative stress, reducing chronic low-grade inflammation, inhibiting adipogenesis and lipogenesis, and suppressing the differentiation of preadipocytes to mature adipocytes.
C1 [Zhao, Yueshui; Shen, Jing; Xiao, Zhangang] Southwest Med Univ, Sch Pharm, Dept Pharmacol, Lab Mol Pharmacol, Luzhou, Sichuan, Peoples R China.
   [Chen, Bo] Kunming Med Univ, Expt Ctr Med Sci Res, Kunming, Yunnan, Peoples R China.
   [Wan, Lin] Childrens Hosp Soochow, Dept Hematol & Oncol, Suzhou, Jiangsu, Peoples R China.
   [Zhu, Yinxin] Soochow Univ, Affiliated Hosp 3, Dept Gastroenterol, Changzhou, Jiangsu, Peoples R China.
   [Yi, Tao] Hong Kong Baptist Univ, Sch Chinese Med, Kowloon, Hong Kong, Peoples R China.
   [Xiao, Zhangang] Southwest Med Univ, Sch Pharm, Minist Educ, Key Lab Med Electrophysiol, Luzhou, Sichuan, Peoples R China.
C3 Southwest Medical University; Kunming Medical University; Soochow
   University - China; Hong Kong Baptist University; Southwest Medical
   University; Ministry of Education - China
RP Xiao, ZG (corresponding author), Southwest Med Univ, Sch Pharm, Dept Pharmacol, Lab Mol Pharmacol, Luzhou, Sichuan, Peoples R China.; Xiao, ZG (corresponding author), Southwest Med Univ, Sch Pharm, Minist Educ, Key Lab Med Electrophysiol, Luzhou, Sichuan, Peoples R China.
EM xzg555898@hotmail.com
RI , yitao/N-6724-2013
OI YI, Tao/0000-0002-4089-3611; XIAO, Zhangang/0000-0003-3249-1118; ZHAO,
   YUESHUI/0000-0002-1972-6130
FU National Natural Science Foundation of China [81503093, 81602166,
   81672444]; Natural Science Foundation of Jiangsu Province [BK2014086]
FX This study is supported by grants from the National Natural Science
   Foundation of China (Grant nos. 81503093, 81602166, and 81672444) and
   the Natural Science Foundation of Jiangsu Province (BK2014086).
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NR 103
TC 151
Z9 156
U1 0
U2 42
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PY 2017
VL 2017
AR 1459497
DI 10.1155/2017/1459497
PG 8
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA FE6VY
UT WOS:000408348200001
PM 29138673
OA Green Published, hybrid, Green Submitted
DA 2025-06-11
ER

PT J
AU Fan, JH
   Liu, YQ
   Yin, SP
   Chen, NX
   Bai, XX
   Ke, QY
   Shen, J
   Xia, M
AF Fan, Jiahua
   Liu, Yangqing
   Yin, Songping
   Chen, Nixuan
   Bai, Xinxiu
   Ke, Qiuyi
   Shen, Jia
   Xia, Min
TI Small dense LDL cholesterol is associated with metabolic syndrome traits
   independently of obesity and inflammation
SO NUTRITION & METABOLISM
LA English
DT Article
DE Metabolic syndrome; Small dense LDL cholesterol; Lipid metabolism
ID INCIDENT CARDIOVASCULAR-DISEASE; CORONARY-HEART-DISEASE;
   TUMOR-NECROSIS-FACTOR; C-REACTIVE PROTEIN; LIPOPROTEIN-CHOLESTEROL;
   ATHEROSCLEROSIS RISK; OXIDATIVE STRESS; MORTALITY; INTERLEUKIN-6;
   PREVALENCE
AB Small dense LDL cholesterol (sdLDL-c) has been established to be highly associated with metabolic disorder. However, the relationship between circulating sdLDL-c and the presence of metabolic syndrome (MetS) has not been fully established.
   A total of 1065 Chinese males (45.07 +/- 11.08 years old) without diabetes and general obesity was recruited into a population-based, cross-sectional study. The MetS was defined based on the updated National Cholesterol Education Program/ Adult Treatment Panel III criteria for Asian Americans. Serum sdLDL-c concentration was measured by a homogeneous assay method and its relationship with MetS and its traits was investigated.
   Serum sdLDL-c concentrations increased gradually with increasing numbers of MetS components (p < 0.001) and the proportion of patients with MetS increased gradually with increasing sdLDL-c levels (p for trend < 0.001). For the second, third, and fourth sdLDL-c quartiles versus the first, the OR (95% CI) for MetS were 4.47(2.41,8.28), 5.47(2.97,10.07) and 8.39(4.58,15.38) (p < 0.001 for trend) after multivariate adjustment. The stratified analysis conducted according to LDL-c levels showed that the OR between serum sdLDL-c levels and MetS was greater in those LDL-c levels lower than 3.3 mmol/L (OR = 22.97; 95% CI, 7.64-69.09) than in those LDL-c levels higher than 3.3 mmol/L (OR = 17.49; 95% CI, 4.43-68.98). Mediation analysis showed sdLDL-c mediated 38.6% of the association of waist circumference with triglycerides, while the association between sdLDL-c and MetS components did not mediate by hsCRP.
   This study found that high sdLDL-c concentrations were associated with the presence of MetS independently of central obesity and inflammation.
C1 [Fan, Jiahua; Liu, Yangqing; Yin, Songping; Chen, Nixuan; Bai, Xinxiu; Ke, Qiuyi; Shen, Jia; Xia, Min] Sun Yat Sen Univ, Guangdong Prov Key Lab Food Nutr & Hlth, Guangdong Engn Technol Res Ctr Nutr Translat, Dept Nutr,Sch Publ Hlth, Northern Campus, Guangzhou, Guangdong, Peoples R China.
C3 Sun Yat Sen University
RP Xia, M (corresponding author), Sun Yat Sen Univ, Guangdong Prov Key Lab Food Nutr & Hlth, Guangdong Engn Technol Res Ctr Nutr Translat, Dept Nutr,Sch Publ Hlth, Northern Campus, Guangzhou, Guangdong, Peoples R China.
EM fanjh3@mail2.sysu.edu.cn; liuyq49@mail2.sysu.edu.cn;
   yinsp@mail2.sysu.edu.cn; chennx3@mail2.sysu.edu.cn;
   baixinx@mail2.sysu.edu.cn; maomaogege1221@163.com;
   talent.sj@foxmail.com; xiamin@mail.sysu.edu.cn
RI Yang, Yutong/HLW-2136-2023
FU Guangzhou Science and Technology Innovation Committee [201510010220]
FX The Guangzhou Science and Technology Innovation Committee (201510010220)
   supported this work.
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NR 53
TC 47
Z9 52
U1 0
U2 16
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1743-7075
J9 NUTR METAB
JI Nutr. Metab.
PD JAN 21
PY 2019
VL 16
AR 7
DI 10.1186/s12986-019-0334-y
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA HK6JV
UT WOS:000458085000002
PM 30679939
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Fujihara, Y
   Kodo, Y
   Miyoshi, SI
   Watanabe, R
   Toyoda, H
   Mankura, M
   Kabuto, H
   Takayama, F
AF Fujihara, Yuri
   Kodo, Yasumasa
   Miyoshi, Shin-ichi
   Watanabe, Ritsuko
   Toyoda, Hiroshi
   Mankura, Mitsumasa
   Kabuto, Hideaki
   Takayama, Fusako
TI Spirulina platensis and its ingredient biopterin glucoside
   improved insulin sensitivity in non-alcoholic steatohepatitis model
SO JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION
LA English
DT Article
DE metabolic syndrome; oxidative stress; inflammation; insulin resistance
ID RAT MODEL; TETRAHYDROBIOPTERIN; RESISTANCE; LIVER; HYDROXYLATION;
   ELEVATION; TARGET
AB Non-alcoholic steatohepatitis is the chronic liver disease leading to cirrhosis and cancer and its prevalence is increasing. Some agents are under clinical trials for non-alcoholic steatohepatitis treatment. We previously reported Spirulina (Arthrospira) platensis effectively prevented non-alcoholic steatohepatitis progression in our model rats. The contribution of phycocyanin, an ingredient of Spirulina (Arthrospira) platensis, was limited. We, therefore, have looked for more active components of Spirulina (Arthrospira) platensis. In this study, we pursued the effect of biopterin glucoside, another bioactive ingredient of Spirulina (Arthrospira) platensis. We found Spirulina (Arthrospira) platensis and biopterin glucoside oral administrations effectively alleviated oxidative stress, inflammation and insulin signal failure, and prevented fibroblast growth factor 21 gene overexpression in non-alcoholic steatohepatitis rat livers. We concluded biopterin glucoside is a major component of Spirulina (Arthrospira) platensis action.
C1 [Fujihara, Yuri; Miyoshi, Shin-ichi; Takayama, Fusako] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Kita Ku, 1-1 Tsushima Naka, Okayama 7008530, Japan.
   [Kodo, Yasumasa] Spirulina BioLab Co Ltd, Yodogawa Ku, 1-13-6 Nishinakajima, Osaka 5320011, Japan.
   [Watanabe, Ritsuko; Toyoda, Hiroshi] Okayama Kyoritsu Gen Hosp, Naka Ku, 8-10 Akasakahonmachi, Okayama 7038288, Japan.
   [Mankura, Mitsumasa] Kurashiki Sakuyo Univ, 3515 Tamashima Nagao, Kurashiki, Okayama 7100292, Japan.
   [Kabuto, Hideaki] Kagawa Prefectural Coll Hlth Sci, 281-1 Murechohara, Takamatsu, Kagawa 7610123, Japan.
C3 Okayama University
RP Takayama, F (corresponding author), Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Kita Ku, 1-1 Tsushima Naka, Okayama 7008530, Japan.
EM takayamf@cc.okayama-u.ac.jp
FU Japan Society for the Promotion of Science [25350886]; Grants-in-Aid for
   Scientific Research [25350886] Funding Source: KAKEN
FX This work was supported by the Japan Society for the Promotion of
   Science, Grant number 25350886. We would like to express the
   appreciation to Shigeru Okada (Graduate School of Medicine, Dentistry
   and Pharmaceutical Sciences, Okayama University, Okayama, Japan) for
   revision of this manuscript.
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NR 41
TC 0
Z9 0
U1 0
U2 9
PU JOURNAL CLINICAL BIOCHEMISTRY & NUTRITION
PI KYOTO
PA KYOTO PREFECTURAL UNIV MED, GRAD SCH MEDICAL SCIENCE, DEPT MOLECULAR
   GASTROENTEROLOGY & HEPATOLOGY, KYOTO, 602-8566, JAPAN
SN 0912-0009
EI 1880-5086
J9 J CLIN BIOCHEM NUTR
JI J. Clin. Biochem. Nutr.
PD SEP
PY 2021
VL 69
IS 2
BP 151
EP 157
DI 10.3164/jcbn.20-201
PG 7
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA UK6UG
UT WOS:000692102100006
PM 34616107
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Vine, D
   Ghosh, M
   Wang, T
   Bakal, J
AF Vine, Donna
   Ghosh, Mahua
   Wang, Ting
   Bakal, Jeffrey
TI Increased Prevalence of Adverse Health Outcomes Across the Lifespan in
   Those Affected by Polycystic Ovary Syndrome: A Canadian Population
   Cohort
SO CJC OPEN
LA English
DT Article
ID INTIMA-MEDIA THICKNESS; QUALITY-OF-LIFE; CARDIOVASCULAR-DISEASE;
   INSULIN-RESISTANCE; PREGNANCY COMPLICATIONS; METABOLIC SYNDROME;
   DIABETES-MELLITUS; INCREASED RISK; LIPID PROFILE; CO-MORBIDITY
AB Background: Polycystic ovary syndrome (PCOS) is the most common metabolic -endocrine disorder impacting the health and quality of life of women over the lifespan. Evidence -based data on the scope of adverse health outcomes in those affected by PCOS is critical to improve healthcare and quality of life in this population. The aim of this study was to determine the prevalence of adverse health outcomes in those with PCOS compared to age -matched controls. Methods: We conducted a retrospective observational case -control study in those diagnosed with PCOS and age -matched controls using the Alberta Health Services Health Analytics database and the International Classification of Diseases, for the period from 2002-2018 in Alberta, Canada. Results: The cohort consisted of n =16,531 exposed PCOS cases and n = 49,335 age -matched un-exposed controls. The prevalences of hypertension, renal disease, gastrointestinal disease, eating disorders, mental illness, depression -anxiety, rheumatoid arthritis, respiratory infections, and all malignancies were 20%-40% (P < 0.0001) higher in those with PCOS, compared to controls. The prevalence of obesity, dyslipidemia, nonalcoholic fatty liver disease, and type 2 diabetes was 2-3 fold higher in those with PCOS (P < 0.001). Cardiovascular, cerebrovascular, and peripheral vascular disease were 30%-50% higher, and they occurred 3-4 years earlier in those with PCOS (P < 0.0001); a 2 -fold higher prevalence of dementia occurred in those with PCOS, compared to controls. Conclusion: These findings provide evidence that PCOS is associated with a higher prevalence of morbidities over the lifespan, and the potential scope of the healthcare burden in women affected by PCOS.
C1 [Vine, Donna] Univ Alberta, Metab & Cardiovasc Dis Lab, Edmonton, AB, Canada.
   [Ghosh, Mahua] Univ Alberta, Fac Med & Dent, Div Endocrinol & Metab, Edmonton, AB, Canada.
   [Wang, Ting; Bakal, Jeffrey] Alberta Hlth Serv, Prov Res Data Serv, Alberta Strategy Patient Orientated Res, Edmonton, AB, Canada.
   [Vine, Donna] Univ Alberta, 4-002 Li Ka Shing Hlth Res Innovat Ctr, Edmonton, AB T6G 2E1, Canada.
C3 University of Alberta; University of Alberta; Alberta Health Services
   (AHS); University of Alberta
RP Vine, D (corresponding author), Univ Alberta, 4-002 Li Ka Shing Hlth Res Innovat Ctr, Edmonton, AB T6G 2E1, Canada.
EM donna.vine@ualberta.ca
RI Wang, Ting/ISB-2796-2023
OI Vine, Donna/0000-0001-7816-3422
FU Women and Children's Health Research Institute; University of Alberta
   Medical Research Foundation, Canada
FX This research was funded by the Women and Children's Health Research
   Institute and the University of Alberta Medical Research Foundation,
   Canada.
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NR 139
TC 19
Z9 20
U1 1
U2 2
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2589-790X
J9 CJC OPEN
JI CJC Open
PD FEB
PY 2024
VL 6
IS 2
BP 314
EP 326
DI 10.1016/j.cjco.2023.12.010
EA MAR 2024
PN B
PG 13
WC Cardiac & Cardiovascular Systems
WE Emerging Sources Citation Index (ESCI)
SC Cardiovascular System & Cardiology
GA OA2E4
UT WOS:001204465200001
PM 38487056
OA gold
DA 2025-06-11
ER

PT J
AU Bundalo, M
   Zivkovic, M
   Tepavcevic, S
   Culafic, T
   Koricanac, G
   Stankovic, A
AF Bundalo, M.
   Zivkovic, M.
   Tepavcevic, S.
   Culafic, T.
   Koricanac, G.
   Stankovic, A.
TI Fructose-Rich Diet-Induced Changes in the Expression of the Renin
   Angiotensin System Molecules in the Heart of Ovariectomized Female Rats
   Could be Reversed by Estradiol
SO HORMONE AND METABOLIC RESEARCH
LA English
DT Article
DE metabolic syndrome; ovariectomy; angiotensin converting enzyme;
   angiotensin converting enzyme 2; angiotensin II type 1 receptor;
   angiotensin II type 2 receptor
ID II TYPE-1 RECEPTOR; INSULIN-RESISTANCE; ESTROGEN REPLACEMENT; CONVERTING
   ENZYME; OXIDATIVE STRESS; NITRIC-OXIDE; INFLAMMATION; GLUCOSE
AB The renin-angiotensin system has been implicated in the development of metabolic syndrome and appears to be a key in the local tissue control of normal cardiac functions. Physiological concentrations of estrogens have been shown to be cardioprotective, especially against the damaging effects of fructose-rich diet. The aim of the study was to investigate the expression of the renin-angiotensin system molecules with potentially deleterious effect on the heart (angiotensin-converting enzyme and angiotensin II type 1 receptor) and those with potentially protective effects, (angiotensin-converting enzyme 2 and angiotensin II type 2 receptor), in ovariectomized fructose fed female rats with 17-estradiol replacement. Real-time PCR and Western blot analysis were used for quantification of gene and protein expression in the heart. Fructose diet increased the expression of angiotensin-converting enzyme and angiotensin II type 1 receptor and decreased the expression of angiotensin-converting enzyme 2 and angiotensin II type 2 receptor. On the other hand, estradiol replacement seems to undo fructose diet effects on cardiac renin-angiotensin system. Downregulation of angiotensin-converting enzyme and angiotensin II type 1 receptor, and reversion of expression of both potentially protective molecules, angiotensin-converting enzyme 2 and angiotensin II type 2 receptor, to the control level in cardiac tissue took place. Obtained results suggest that estradiol may reverse the harmful effect of fructose-rich diet on the expression of renin-angiotensin system molecules. These findings may also be important in further research of phenotypes like insulin resistance, metabolic syndrome, and following cardiovascular pathology in females.
C1 [Bundalo, M.; Zivkovic, M.; Tepavcevic, S.; Culafic, T.; Koricanac, G.; Stankovic, A.] Univ Belgrade, Lab Radiobiol & Mol Genet, Vinca Inst Nucl Sci, Belgrade 11000, Serbia.
C3 University of Belgrade
RP Stankovic, A (corresponding author), Univ Belgrade, Lab Radiobiol & Mol Genet, Vinca Inst Nucl Sci, POB 522, Belgrade 11000, Serbia.
EM alexas@vinca.rs
RI Korićanac, Goran/ABF-6544-2021; Zivkovic, Maja/T-1038-2018; Stankovic,
   Aleksandra/T-1064-2018
OI Zivkovic, Maja/0000-0002-0447-6626; Bundalo, Maja/0000-0002-0589-2672;
   Koricanac, Goran/0000-0002-9852-3330; Stankovic,
   Aleksandra/0000-0002-1050-5913; Tepavcevic, Snezana/0000-0002-5758-070X;
   Culafic, Tijana/0000-0002-8161-3647
FU Ministry of Education, Science and Technological Development of the
   Republic of Serbia [OI175085, III 41009]
FX This work was supported by The Ministry of Education, Science and
   Technological Development of the Republic of Serbia (grant numbers
   OI175085 and III 41009).
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NR 38
TC 8
Z9 9
U1 0
U2 6
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0018-5043
EI 1439-4286
J9 HORM METAB RES
JI Horm. Metab. Res.
PD JUN
PY 2015
VL 47
IS 7
BP 521
EP 527
DI 10.1055/s-0034-1394373
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA CJ2RM
UT WOS:000355332200009
PM 25369074
DA 2025-06-11
ER

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AF Tabur, S.
   Oztuzcu, S.
   Duzen, I. V.
   Eraydin, A.
   Eroglu, S.
   Ozkaya, M.
   Demiryurek, A. T.
TI Role of the transient receptor potential (TRP) channel gene expressions
   and TRP melastatin (TRPM) channel gene polymorphisms in obesity-related
   metabolic syndrome
SO EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
LA English
DT Article
DE Expression; Gene variants; Metabolic syndrome; Obesity; Transient
   receptor potential
ID CATION CHANNELS; OXIDATIVE STRESS; INSULIN-RESISTANCE; NATIONAL-HEALTH;
   ADP-RIBOSE; PREVALENCE; ASSOCIATION; IMPACT; HERITABILITY; ACTIVATION
AB OBJECTIVE: Metabolic syndrome (MetS) is correlated with increased cardiovascular risk and characterized by several factors, including visceral obesity, hypertension, dyslipidemia, and insulin resistance. The etiology of MetS is complex, and can be influenced by genetic susceptibility. The aim of this study was to investigate a possible association of transient receptor potential (TRP) channels gene expressions and TRP melastatin (TRPM) gene polymorphisms with MetS in a Turkish population.
   PATIENTS AND METHODS: A total of 142 patients with obesity-related MetS and 166 healthy controls with similar age and sex were enrolled to this study. For polymorphism studies, genomic DNA from the participants was analyzed by a BioMark 96.96 dynamic array system (Fluidigm, South San Francisco, CA, USA). For gene expression studies, mRNA from blood samples was extracted, and real time polymerase chain reaction on the BioMark HD system was performed.
   RESULTS: There was an increase in A allele (64.6% in patients vs. 49.5% in controls) and decrease in G allele frequencies (35.4% in patients vs. 50.5% in control, p = 0.0019) of the TRPM5 gene rs4929982 (Arg578Gln) polymorphism. We also observed that the distribution of genotype and allele frequencies of the TRPM8 gene rs12472151 in MetS patients were significantly different from controls (p < 0.0001). Although there were marked decreases in TRPC1, TRPC3, TRPM2, TRPM5, TRPV4, TRPV5, TRPV6, MCOLN2 (TRPML2), and MCOLN3 (TRPML3) gene expressions, an augmentation was noted in TRPC6 gene expression.
   CONCLUSIONS: Genetic polymorphisms in TRPM5 and TRPM8 genes may modify individual susceptibility to MetS in the Turkish population. This study also revealed that there is a significant relationship between TRP channels gene expressions and MetS.
C1 [Tabur, S.; Eraydin, A.; Ozkaya, M.] Gaziantep Univ, Fac Med, Dept Internal Med, Div Endocrinol, Gaziantep, Turkey.
   [Oztuzcu, S.; Eroglu, S.] Gaziantep Univ, Dept Med Biol, Fac Med, Gaziantep, Turkey.
   [Duzen, I. V.] 25 Aralik State Hosp, Dept Cardiol, Gaziantep, Turkey.
   [Demiryurek, A. T.] Gaziantep Univ, Dept Med Pharmacol, Fac Med, Gaziantep, Turkey.
C3 Gaziantep University; Gaziantep University; December 25 State Hospital;
   Gaziantep University
RP Tabur, S (corresponding author), Gaziantep Univ, Fac Med, Dept Internal Med, Div Endocrinol, Gaziantep, Turkey.
EM suzan2471@yahoo.com.tr
RI Demiryurek, Abdullah/AAG-5244-2020; DÜZEN, İRFAN/AAH-1159-2020; Eroglu,
   Secil/P-2209-2019
OI Eroglu, Secil/0000-0002-1536-1736
FU University of Gaziantep [TF.13.20]
FX This study was funded by a project (TF.13.20) from the University of
   Gaziantep.
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NR 50
TC 31
Z9 34
U1 0
U2 8
PU VERDUCI PUBLISHER
PI ROME
PA VIA GREGORIO VII, ROME, 186-00165, ITALY
SN 1128-3602
J9 EUR REV MED PHARMACO
JI Eur. Rev. Med. Pharmacol. Sci.
PD APR
PY 2015
VL 19
IS 8
BP 1388
EP 1397
PG 10
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA CI1WG
UT WOS:000354535200011
PM 25967713
DA 2025-06-11
ER

PT J
AU Yamazaki, Y
   Kondo, K
   Maeba, R
   Nishimukai, M
   Nezu, T
   Hara, H
AF Yamazaki, Yuya
   Kondo, Kazuya
   Maeba, Ryouta
   Nishimukai, Megumi
   Nezu, Toru
   Hara, Hiroshi
TI The Proportion of Nervonic Acid in Serum Lipids is Associated with Serum
   Plasmalogen Levels and Metabolic Syndrome
SO JOURNAL OF OLEO SCIENCE
LA English
DT Article
DE very long chain fatty acid; nervonic acid; plasmalogen; metabolic
   syndrome; peroxisomal dysfunction
ID X-LINKED ADRENOLEUKODYSTROPHY; CHAIN FATTY-ACIDS; ETHANOLAMINE
   PLASMALOGENS; PEROXISOMAL DISORDERS; OXIDATION; ELONGATION; DISEASE;
   ETHER; ATHEROSCLEROSIS; SPECTROMETRY
AB An increase in serum plasmalogens (1-O-alk-1-enyl-2-acyl glycerophospholipids), which are endogenous anti-oxidative phospholipids, can potentially prevent age-related diseases such as atherosclerosis and metabolic syndrome (MetS). Very long chain fatty acids (VLCFAs) in plasma may supply the materials for plasmalogen biosynthesis through peroxisomal beta-oxidation. On the other hand, elevated levels of saturated and monounsaturated VLCFAs in plasma appear to be associated with decreased peroxisomal function, and are a symptom of age-related diseases. To reconcile these contradictory findings, we attempted to investigate the relationship between the serum levels of saturated and monounsaturated VLCFAs, clinical and biochemical parameters, and serum levels of plasmalogens in subjects with MetS (n = 117), who were asymptomatic Japanese males over 40 years of age. Fatty acids in serum lipids were quantified using gas chromatography/mass spectrometry (GC/MS). Serum plasmalogen levels were determined by liquid chromatography using radioactive iodine (I-125-HPLC), and the molecular composition of serum plasmalogens was analyzed by liquid chromatography-tandem mass spectrometry (LC/MS/MS). We found that MetS subjects showed a significant reduction in the proportion of specific saturated and monounsaturated VLCFAs such as behenic acid (C22:0), lignoceric acid (C24:0), and nervonic acid (C24:1) in serum lipids compared to non-MetS subjects. These VLCFAs were positively associated with serum levels of high density lipoprotein cholesterol (HDL-C) as well as plasmalogen-related parameters, and inversely with serum levels of triglyceride (TG) and small dense low density lipoprotein cholesterol (sdLDL-C). In conclusion, the proportion of nervonic acid in serum lipids is associated with serum levels of plasmalogens and with MetS, and probably reflects the peroxisomal dysfunction and enhancement of endoplasmic reticulum (ER) stress seen in common age-related diseases.
C1 [Yamazaki, Yuya; Kondo, Kazuya; Nezu, Toru] ADEKA Co, Food Dev Lab, Arakawa Ku, Tokyo 1168553, Japan.
   [Kondo, Kazuya] Teikyo Univ, Sch Med, Dept Biochem, Itabashi Ku, Tokyo 1738605, Japan.
   [Nishimukai, Megumi; Hara, Hiroshi] Hokkaido Univ, Div Appl Biosci, Res Fac Agr, Kita Ku, Sapporo, Hokkaido 0608589, Japan.
   [Nishimukai, Megumi] Iwate Univ, Fac Agr, Dept Anim Sci, Morioka, Iwate 0208550, Japan.
C3 Teikyo University; Hokkaido University; Iwate University
RP Maeba, R (corresponding author), Teikyo Univ, Sch Med, Dept Biochem, Itabashi Ku, 2-11-1 Kaga, Tokyo 1738605, Japan.
EM maeba@med.teikyo-u.ac.jp
RI HARA, HIROSHI/A-4581-2012
FU "Knowledge Cluster Initiative" of the Ministry of Education, Science,
   Sports and Culture of Japan
FX We would like to thank Professor Hiroshi Chiba from the Faculty of
   Health Sciences, Hokkaido University for measurements of sdLDL-C, hsCRP,
   Hcy, and adiponectin. This study was supported by the "Knowledge Cluster
   Initiative" (2nd stage, "Sapporo Biocluster Bio-S") of the Ministry of
   Education, Science, Sports and Culture of Japan.
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NR 40
TC 58
Z9 65
U1 4
U2 41
PU JAPAN OIL CHEMISTS SOC
PI TOKYO
PA YUSHI KOGYO KAIKAN BLDG, 13-11, NIHONBASHI 3-CHOME, CHUO-KU, TOKYO,
   103-0027, JAPAN
SN 1345-8957
EI 1347-3352
J9 J OLEO SCI
JI J. Oleo Sci.
PD MAY
PY 2014
VL 63
IS 5
BP 527
EP 537
DI 10.5650/jos.ess13226
PG 11
WC Chemistry, Applied; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Food Science & Technology
GA AG0CV
UT WOS:000335083800011
PM 24770479
OA Bronze
DA 2025-06-11
ER

PT J
AU Zeng, YW
   Ali, MK
   Du, J
   Li, X
   Yang, XM
   Yang, JZ
   Pu, XY
   Yang, L
   Hong, JG
   Mou, B
   Li, L
   Zhou, Y
AF Zeng, Yawen
   Ali, Muhammad Kazim
   Du, Juan
   Li, Xia
   Yang, Xiaomeng
   Yang, Jiazhen
   Pu, Xiaoying
   Yang, Li'E
   Hong, Jingan
   Mou, Bo
   Li, Ling
   Zhou, Yan
TI Resistant Starch in Rice: Its Biosynthesis and Mechanism of Action
   Against Diabetes-Related Diseases
SO FOOD REVIEWS INTERNATIONAL
LA English
DT Review
DE Functional rice; resistant starch; diabetes; biosynthesis; action
   mechanisms; metabolic syndrome
ID IN-VITRO DIGESTIBILITY; BRANCHING-ENZYME-IIB; DIET-INDUCED OBESITY;
   ORYZA-SATIVA L.; BROWN RICE; GAMMA-ORYZANOL; COOKED RICE;
   MOLECULAR-STRUCTURE; OXIDATIVE STRESS; MUTANT RICE
AB Rice with a high resistant starch (RS) content is one the most commonly used, effective, and safe functional foods, which can be used to prevent diabetes and its related complications in humans. Based on the health benefits (highest to lowest), the types of RS can be categorized as follows: RS1> RS3> RS5> RS4> RS2. Here, we discuss the biosynthesis and mechanism of action [processing changes, biochemistry, and glycemic index (GI)] of the five RS types present in rice as well as their potential of preventing diabetes-related diseases, based on reports published from 2004 to 2021 in PubMed, CNKI, and ISI Web of Science databases. High-RS rice has gained considerable interest owing to the advantages it offers as a staple food product and its potential for controlling appetite with satiety, lowering glucose levels in the stomach and small intestine, and increasing the short-chain fatty acid content in the large intestine, which helps combat metabolic syndrome by controlling gluconeogenesis, promoting glycogenesis, maintaining glucose and lipid homeostasis, and improving pancreatic function. Rice is an important source of RS (>3%, GI<55) and can help prevent diabetes. However, certain types of rice have a high GI (>85), which may induce metabolic syndrome. The RS content of rice ranges from 0.1% to 25.4% and the GI ranges from 44 to 132, which has many factors relating in the white rice. In this review, we discuss the diversity in RS content based on the biosynthetic mechanism and the mechanism of action of high-RS rice in diabetes. We also discuss potential limitations of rice breeding programs and the methods that can be used to ensure the availability of effective, yet palatable, high-RS rice.
C1 [Zeng, Yawen; Ali, Muhammad Kazim; Du, Juan; Li, Xia; Yang, Xiaomeng; Yang, Jiazhen; Pu, Xiaoying; Yang, Li'E] Yunnan Acad Agr Sci, Biotechnol & Germplasm Resources Inst, Agr Biotechnol Key Lab Yunnan Prov, Kunming 650205, Yunnan, Peoples R China.
   [Ali, Muhammad Kazim] Univ Karachi, Karachi Inst Biotechnol & Genet Engn, Karachi, Pakistan.
   [Yang, Xiaomeng] Minist Agr, Key Lab Southwestern Crop Gene Resources & Germp, Kunming, Yunnan, Peoples R China.
   [Hong, Jingan] First Peoples Hosp Yunnan Prov, Clin Nutr Dept, Kunming, Yunnan, Peoples R China.
   [Mou, Bo; Zhou, Yan] Second Peoples Hosp Yunnan Prov, Clin Nutr Dept, Kunming, Yunnan, Peoples R China.
   [Li, Ling] Kunming Med Univ, Biomed Engn Res Ctr, Kunming, Yunnan, Peoples R China.
C3 Yunnan Academy of Agricultural Sciences; University of Karachi; Ministry
   of Agriculture & Rural Affairs; Kunming University of Science &
   Technology; Yunnan University; Kunming Medical University
RP Zeng, YW (corresponding author), Yunnan Acad Agr Sci, Biotechnol & Germplasm Resources Inst, Agr Biotechnol Key Lab Yunnan Prov, Kunming 650205, Yunnan, Peoples R China.; Ali, MK (corresponding author), Univ Karachi, Karachi Inst Biotechnol & Genet Engn, Karachi, Pakistan.; Yang, XM (corresponding author), Key Lab Southwestern Crop Gene Resources & Germpl, Kunming, Yunnan, Peoples R China.
EM zengyw1967@126.com; kazim.ali@kibge.edu.pk; yxm89ccf@126.com
OI jiazhen, yang/0000-0003-2201-3059; Zeng, Yawen/0000-0001-7616-9177
FU National Natural Science Foundation of China [31760376, 30660092]
FX This work was funded by the National Natural Science Foundation of China
   (No. 31760376; 30660092).
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NR 205
TC 15
Z9 15
U1 3
U2 97
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 8755-9129
EI 1525-6103
J9 FOOD REV INT
JI Food Rev. Int.
PY 2023
VL 39
IS 7
BP 4364
EP 4387
DI 10.1080/87559129.2021.2024221
EA JAN 2022
PG 24
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA U5IO8
UT WOS:000742918100001
DA 2025-06-11
ER

PT J
AU Halajzadeh, J
   Milajerdi, A
   Reiner, Z
   Amirani, E
   Kolahdooz, F
   Barekat, M
   Mirzaei, H
   Mirhashemi, SM
   Asemi, Z
AF Halajzadeh, Jamal
   Milajerdi, Alireza
   Reiner, Zeljko
   Amirani, Elaheh
   Kolahdooz, Fariba
   Barekat, Maryam
   Mirzaei, Hamed
   Mirhashemi, Seyyed Mehdi
   Asemi, Zatollah
TI Effects of resistant starch on glycemic control, serum lipoproteins and
   systemic inflammation in patients with metabolic syndrome and related
   disorders: A systematic review and meta-analysis of randomized
   controlled clinical trials
SO CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
LA English
DT Review
DE Resistant starch; insulin resistance; metabolic syndrome;
   LDL-cholesterol; HDL-cholesterol; meta-analysis
ID CHAIN FATTY-ACIDS; GUT MICROBIOTA; CARDIOVASCULAR-DISEASE; INSULIN
   SENSITIVITY; LIPID CONCENTRATIONS; OXIDATIVE STRESS; ADIPOSE-TISSUE;
   RISK; MANAGEMENT; HEALTH
AB The aim of this systematic review and meta-analysis was to evaluate the effects of resistant starch (RS) on glycemic status, serum lipoproteins and inflammatory markers in patients with metabolic syndrome (MetS) and related disorders. Two independent authors systematically searched online database including EMBASE, Scopus, PubMed, Cochrane Library, and Web of Science from inception until 30 April 2019. Cochrane Collaboration risk of bias tool was applied to assess the methodological quality of included trials. The heterogeneity among the included studies was assessed using Cochrane's Q test and I-square (I-2) statistic. Data were pooled using a random-effects model and weighted mean difference (WMD) was considered as the overall effect size. Nineteen trials were included in this meta-analysis. Administration of RS resulted in significant reduction in fasting plasma glucose (FPG) (14 studies) (WMD: -4.28; 95% CI: -7.01, -1.55), insulin (12 studies) (WMD: -1.95; 95% CI: -3.22, -0.68), and HbA1C (8 studies) (WMD: -0.60; 95% CI: -0.95, -0.24). When pooling data from 13 studies, a significant reduction in total cholesterol levels (WMD: -8.19; 95% CI: -15.38, -1.00) and LDL-cholesterol (WMD: -8.57; 95% CI: -13.48, -3.66) were found as well. Finally, RS administration was associated with a significant decrease in tumor necrosis factor alpha (TNF-alpha) (WMD: -2.02; 95% CI: -3.14, -0.90). This meta-analysis showed beneficial effects of RS on improving FPG, insulin, HbA1c, total cholesterol, LDL-cholesterol and TNF-alpha levels in patients with MetS and related disorders, but it did not affect HOMA-IR, triglycerides, HDL-cholesterol, CRP and IL-6 levels.
C1 [Halajzadeh, Jamal] Maraghe Univ Med Sci, Res Ctr Evidence Based Hlth Management, Dept Biochem & Nutr, Maraghe, Iran.
   [Milajerdi, Alireza] Univ Tehran Med Sci, Students Sci Res Ctr, Tehran, Iran.
   [Milajerdi, Alireza] Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Community Nutr, Tehran, Iran.
   [Reiner, Zeljko] Univ Zagreb, Univ Hosp, Sch Med, Ctr Zagreb,Dept Internal Med, Zagreb, Croatia.
   [Amirani, Elaheh; Mirzaei, Hamed; Asemi, Zatollah] Kashan Univ Med Sci, Res Ctr Biochem & Nutr Metab Dis, Kashan, Iran.
   [Kolahdooz, Fariba] Univ Alberta, Dept Med, Indigenous & Global Hlth Res, Edmonton, AB, Canada.
   [Barekat, Maryam] ACECR, Royan Inst Stem Cell Biol & Technol, Dept Regenerat Biomed, Cell Sci Res Ctr, Tehran, Iran.
   [Mirhashemi, Seyyed Mehdi] Qazvin Univ Med Sci, Metab Dis Res Ctr, Res Inst Prevent Noncommunicable Dis, Qazvin, Iran.
C3 Tehran University of Medical Sciences; Tehran University of Medical
   Sciences; University of Zagreb; University of Alberta; Academic Center
   for Education, Culture & Research (ACECR); Qazvin University of Medical
   Sciences (QUMS)
RP Asemi, Z (corresponding author), Kashan Univ Med Sci, Res Ctr Biochem & Nutr Metab Dis, Kashan, Iran.; Barekat, M (corresponding author), ACECR, Royan Inst Stem Cell Biol & Technol, Dept Regenerat Biomed, Cell Sci Res Ctr, Tehran, Iran.
EM Barekat1001@yahoo.com; asemi_r@yahoo.com
RI Milajerdi, Alireza/ABB-1854-2020; Mirhashemi, Seyyed/K-8628-2017;
   Popescu, Bogdan A./AAA-1319-2022; Asemi, Zatollah/G-7393-2017
FU Kashan University of Medical Sciences, in Iran
FX The present study was founded by a grant from the Vice Chancellor for
   Research, Kashan University of Medical Sciences, in Iran.
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NR 56
TC 42
Z9 43
U1 0
U2 51
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1040-8398
EI 1549-7852
J9 CRIT REV FOOD SCI
JI Crit. Rev. Food Sci. Nutr.
PD OCT 10
PY 2020
VL 60
IS 18
BP 3172
EP 3184
DI 10.1080/10408398.2019.1680950
EA OCT 2019
PG 13
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA NY9OO
UT WOS:000493126300001
PM 31661295
DA 2025-06-11
ER

PT J
AU Romana, BS
   Chela, H
   Dailey, FE
   Nassir, F
   Tahan, V
AF Romana, Bhupinder S.
   Chela, Harleen
   Dailey, Francis E.
   Nassir, Fatiha
   Tahan, Veysel
TI Non-alcoholic Fatty Pancreas Disease (NAFPD): A Silent Spectator or the
   Fifth Component of Metabolic Syndrome? A Literature Review
SO ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS
LA English
DT Review
DE Non-alcoholic; fatty; pancreas; steatopancreatitis; epidemiology;
   pathophysiology; diagnosis; treatment
ID BETA-CELL FUNCTION; ECTOPIC FAT; INSULIN-RESISTANCE; DIABETES-MELLITUS;
   OXIDATIVE STRESS; LIVER-DISEASE; RISK-FACTOR; OBESITY; STEATOSIS;
   ACCUMULATION
AB Background and Objective: Fat accumulation in the pancreas has remained a relatively unknown disease since it was initially described in 1926. However, it has gained increasing attention in the past two decades with the emergence of the obesity epidemic. Pancreatic steatosis is a general term used for fat accumulation in the pancreas. It is further classified into fatty replacement, fatty infiltration, lipomatous pseudo-hypertrophy, non-alcoholic fatty pancreas disease (NAFPD) and non-alcoholic fatty steatopancreatitis (NASP). NAFPD is defined as obesity-associated accumulation of fat in the pancreas without significant alcohol consumption. Data on the prevalence of NAFPD are limited due to a lack of standardized screening tests.
   Methods: MEDLINE/PubMed was searched to find relevant studies and abstracts on pancreatic steatosis.
   Results: Pancreatic fat can be quantified by various imaging techniques including ultrasonography, computed tomography, magnetic resonance imaging and magnetic resonance spectroscopy. The pathophysiology of NAFPD has not been completely understood. Chronic exposure of beta-cells to hyperglycemia and higher levels of free fatty acids results in increased intracellular triglyceride accumulation, which ultimately causes reduced insulin secretion, insulin resistance, cell apoptosis and subsequent fatty replacement. This vicious cycle likely is a determining factor in the development of diabetes mellitus and metabolic syndrome. There is no approved pharmacologic therapy for NAFPD. Caloric restriction might have a role in normalization of beta-cell function by reducing pancreatic fat content. Troglitazone (blend of telmisartan and sitagliptin) has demonstrated effectiveness in animal models but is still in experimental stages.
   Conclusion: The cause and effect relationship between the metabolic syndrome and NAFPD has not yet been established. Further studies are required to study the effect of NAFPD on glucose hemostasis.
C1 [Romana, Bhupinder S.; Dailey, Francis E.; Nassir, Fatiha; Tahan, Veysel] Univ Missouri, Div Gastroenterol & Hepatol, 1 Hosp Dr, Columbia, MO 65212 USA.
   [Chela, Harleen] Univ Missouri, Dept Internal Med, Columbia, MO USA.
C3 University of Missouri System; University of Missouri Columbia;
   University of Missouri System; University of Missouri Columbia
RP Tahan, V (corresponding author), Univ Missouri, Div Gastroenterol & Hepatol, 1 Hosp Dr, Columbia, MO 65212 USA.
EM tahanv@health.missouri.edu
RI Chela, Harleen/LYO-1450-2024; Tahan, Veysel/K-4806-2019
OI Nassir, Fatiha/0000-0002-3653-3621; Gomes, Maria/0000-0001-5965-9000
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NR 84
TC 37
Z9 38
U1 0
U2 5
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1871-5303
EI 2212-3873
J9 ENDOCR METAB IMMUNE
JI Endocr. Metab. Immune Disord.-Drug Targets
PY 2018
VL 18
IS 6
BP 547
EP 554
DI 10.2174/1871530318666180328111302
PG 8
WC Endocrinology & Metabolism; Immunology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Immunology; Pharmacology & Pharmacy
GA IX9FQ
UT WOS:000485993500001
PM 29595117
DA 2025-06-11
ER

PT J
AU Hong, SA
   Kim, MK
AF Hong, Seo Ah
   Kim, Mi Kyung
TI Relationship between fruit and vegetable intake and the risk of
   metabolic syndrome and its disorders in Korean women according to
   menopausal status
SO ASIA PACIFIC JOURNAL OF CLINICAL NUTRITION
LA English
DT Article
DE fruits; vegetables; metabolic syndrome; menopause; women
ID CARDIOVASCULAR-DISEASE; OXIDATIVE STRESS; DIETARY-INTAKE; NUTRITION;
   HEALTH; SERUM; CARBOHYDRATE; PREVALENCE; PROTEIN
AB Background and Objectives: The association between fruit and vegetable (FV) intake and risk of the metabolic syndrome (MetS) has not been elucidated fully, particularly by menopausal status. Method and Study Design: The study population was 2,999 women aged 40-64 years participating in the 4th Korea National Health and Nutrition Examination Survey. The definition of MetS and its components was based on the modified National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) for Koreans. Dietary data were assessed by a 24-hour recall. Results: Fruit intake was inversely related only to the risk of high blood pressure (BP), but not MetS. Total vegetable consumption was inversely associated with the MetS risk, and when combined with fruits, the inverse association was observed even in its features of high triglycerides (TG) and low HDL-cholesterol as well as MetS. Assessing women by menopausal status revealed that the inverse association with the MetS risk was found only in postmenopausal women having greater total vegetables and total FV intake (aOR=0.47, 95% CI=0.29-0.75, p-trend=0.003 and aOR=0.54, 95% CI=0.35-0.85, p-trend=0.007, respectively). Analysis regarding MetS features showed that while the inverse association of total vegetables or total FV intake was observed with high TG risk in postmenopausal women, fruits intake was inversely associated with high BP risk in premenopausal women (aOR=0.54, 95% CI=0.37-0.79, p-trend=0.004). Conclusion: Results suggest that while fruit intake was inversely associated with high BP in premenopausal women, greater dietary intake of vegetables and total FV may protect against the risk of MetS, particularly in postmenopausal women.
C1 [Hong, Seo Ah] Mahidol Univ, ASEAN Inst Hlth Dev, Salaya, Nakhon Pathom, Thailand.
   [Kim, Mi Kyung] Hanyang Univ, Dept Prevent Med, Coll Med, 17 Haengdang Dong, Seoul 133791, South Korea.
   [Hong, Seo Ah; Kim, Mi Kyung] Hanyang Univ, Inst Hlth & Soc, Seoul, South Korea.
C3 Mahidol University; Hanyang University; Hanyang University
RP Kim, MK (corresponding author), Hanyang Univ, Dept Prevent Med, Coll Med, 17 Haengdang Dong, Seoul 133791, South Korea.
EM kmkkim@hanyang.ac.kr
RI Kim, Mi-Kyung/E-8682-2012; Hong, Seo Ah/E-7628-2015
OI Hong, Seo Ah/0000-0002-6702-8038; Kim, Mi Kyung/0000-0001-8503-2631
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NR 32
TC 13
Z9 14
U1 0
U2 18
PU H E C PRESS, HEALTHY EATING CLUB PTY LTD
PI MCKINNON
PA PO BOX 4121, MCKINNON, VIC 3204, AUSTRALIA
SN 0964-7058
EI 1440-6047
J9 ASIA PAC J CLIN NUTR
JI Asia Pac. J. Clin. Nutr.
PY 2017
VL 26
IS 3
BP 514
EP 523
DI 10.6133/apjcn.042016.03
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA ET2SR
UT WOS:000400124900019
PM 28429918
DA 2025-06-11
ER

PT J
AU Wang, WW
   Zhang, FL
   Xhen, JH
   Chen, XH
   Fu, FY
   Tang, MR
   Chen, LL
AF Wang, Weiwei
   Zhang, Feilong
   Xhen, Jianhua
   Chen, Xuehai
   Fu, Fayuan
   Tang, Mirong
   Chen, Lianglong
TI P-wave dispersion and maximum duration are independently associated with
   insulin resistance in metabolic syndrome
SO ANNALES D ENDOCRINOLOGIE
LA English
DT Article
DE Metabolic syndrome; P-wave dispersion; Insulin resistance; Atrial
   conduction
ID ATRIAL-FIBRILLATION; ATHEROSCLEROSIS RISK; MONONUCLEAR-CELLS; OXIDATIVE
   STRESS; OBESITY; ABNORMALITIES; PREDICTORS; RECURRENCE; MECHANISMS;
   EXPRESSION
AB Background. Metabolic syndrome (MS) is an important risk factor for atrial fibrillation. P-wave indices, including P-wave dispersion (PWD) and P-wave duration, can be used as non-invasive markers of heterogeneous atrial conduction. The aim of our study was to evaluate the relationship between P-wave indices and insulin resistance in patients with MS. Methods. Seventy-four patients with MS (44 men, 30 women) and 81 patients without MS (48 men, 33 women) were enrolled in the study. A diagnosis of MS was made as defined by the Adult Treatment Panel III of the National Cholesterol Education Program. Insulin resistance was estimated using the homeostasis model assessment (HOMA) index. P-wave maximum duration (Pmax) and P-wave minimum duration (Pmin) were calculated on a 12-lead electrocardiogram, and the difference between the Pmax and the Pmin was defined as PWD. Results. Patients with MS had a longer PWD and a higher Pmax compared with patients without MS (PWD, 35.65 +/- 4.36 vs. 26.27 +/- 4.04, P<0.001; Pmax, 117.12 +/- 10.77 vs. 105.98 +/- 9.02, P<0.001), whereas no difference was found between Pmin values from MS patients and controls (81.47 +/- 9.54 vs. 79.70 +/- 8.76, P = 0.231). Stepwise multivariate analysis revealed only the HOMA index to be an independent predictor of PWD (beta = 3.115, P < 0.001) and Pmax (beta = 7.175, P<0.001). Conclusion. This study suggests that patients with MS have a prolonged PWD and Pmax. The increase in these parameters may be an indicator for identification of patients at an increased risk for atrial fibrillation. (C) 2014 Published by Elsevier Masson SAS.
C1 [Wang, Weiwei; Zhang, Feilong; Xhen, Jianhua; Chen, Xuehai; Fu, Fayuan; Tang, Mirong; Chen, Lianglong] Fujian Med Univ, Union Clin Med Coll, Union Hosp, Fuzhou 350001, Peoples R China.
C3 Fujian Medical University
RP Chen, LL (corresponding author), Fujian Med Univ, Union Clin Med Coll, Union Hosp, Dept Coronary Artery Dis, 29 Xin Quan Rd, Fuzhou 350001, Peoples R China.
EM lianglongchenxhyy@126.com
RI xuehai, chen/AED-4476-2022
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NR 41
TC 7
Z9 7
U1 0
U2 5
PU MASSON EDITEUR
PI MOULINEAUX CEDEX 9
PA 21 STREET CAMILLE DESMOULINS, ISSY, 92789 MOULINEAUX CEDEX 9, FRANCE
SN 0003-4266
EI 2213-3941
J9 ANN ENDOCRINOL-PARIS
JI Ann Endocrinol.
PD JUL
PY 2014
VL 75
IS 3
BP 156
EP 161
DI 10.1016/j.ando.2014.05.004
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA AP1DI
UT WOS:000341806200004
PM 25016562
DA 2025-06-11
ER

PT J
AU López-Miranda, J
   Pérez-Jiménez, F
   Ros, E
   De Caterina, R
   Badimón, L
   Covas, MI
   Escrich, E
   Ordovás, JM
   Soriguer, F
   Abiá, R
   de la Lastra, CA
   Battino, M
   Corella, D
   Chamorro-Quirós, J
   Delgado-Lista, J
   Giugliano, D
   Esposito, K
   Estruch, R
   Fernandez-Real, JM
   Gaforio, JJ
   La Vecchia, C
   Lairon, D
   López-Segura, F
   Mata, P
   Menéndez, JA
   Muriana, FJ
   Osada, J
   Panagiotakos, DB
   Paniagua, JA
   Pérez-Martinez, P
   Perona, J
   Peinado, MA
   Pineda-Priego, M
   Poulsen, HE
   Quiles, JL
   Ramírez-Tortosa, MC
   Ruano, J
   Serra-Majem, L
   Solá, R
   Solanas, M
   Solfrizzi, V
   de la Torre-Fornell, R
   Trichopoulou, A
   Uceda, M
   Villalba-Montoro, JM
   Villar-Ortiz, JR
   Visioli, F
   Yiannakouris, N
AF Lopez-Miranda, J.
   Perez-Jimenez, F.
   Ros, E.
   De Caterina, R.
   Badimon, L.
   Covas, M. I.
   Escrich, E.
   Ordovas, J. M.
   Soriguer, F.
   Abia, R.
   Alarcon de la Lastra, C.
   Battino, M.
   Corella, D.
   Chamorro-Quiros, J.
   Delgado-Lista, J.
   Giugliano, D.
   Esposito, K.
   Estruch, R.
   Fernandez-Real, J. M.
   Gaforio, J. J.
   La Vecchia, C.
   Lairon, D.
   Lopez-Segura, F.
   Mata, P.
   Menendez, J. A.
   Muriana, F. J.
   Osada, J.
   Panagiotakos, D. B.
   Paniagua, J. A.
   Perez-Martinez, P.
   Perona, J.
   Peinado, M. A.
   Pineda-Priego, M.
   Poulsen, H. E.
   Quiles, J. L.
   Ramirez-Tortosa, M. C.
   Ruano, J.
   Serra-Majem, L.
   Sola, R.
   Solanas, M.
   Solfrizzi, V.
   de la Torre-Fornell, R.
   Trichopoulou, A.
   Uceda, M.
   Villalba-Montoro, J. M.
   Villar-Ortiz, J. R.
   Visioli, F.
   Yiannakouris, N.
TI Olive oil and health: Summary of the II international conference on
   olive oil and health consensus report, Jaen and Cordoba (Spain) 2008
SO NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
LA English
DT Review
DE Olive oil; Mediterranean diet Phenolic compounds; Cardiovascular
   disease; Cancer; Obesity; Diabetes; Metabolic syndrome
ID CORONARY-HEART-DISEASE; DIETARY FATTY-ACIDS; CARDIOVASCULAR
   RISK-FACTORS; MEDITERRANEAN-STYLE DIET; BLOOD MONONUCLEAR-CELLS;
   BODY-MASS INDEX; METABOLIC SYNDROME; OLEIC-ACID; COGNITIVE DECLINE;
   INSULIN SENSITIVITY
AB Olive oil (OO) is the most representative food of the traditional Mediterranean Diet (MedDiet). Increasing evidence suggests that monounsaturated fatty acids (MUFA) as a nutrient, OO as a food, and the MedDiet as a food pattern are associated with a decreased risk of cardiovascular disease, obesity, metabolic syndrome, type 2 diabetes and hypertension. A MedDiet rich in OO and OO per se has been shown to improve cardiovascular risk factors, such as lipid profiles, blood pressure, postprandial hyperlipidemia, endothelial dysfunction, oxidative stress, and antithrombotic profiles. Some of these beneficial effects can be attributed to the OO minor components. Therefore, the definition of the MedDiet should include OO. Phenolic compounds in OO have shown antioxidant and anti-inflammatory properties, prevent lipoperoxidation, induce favorable changes of lipid profile, improve endothelial function, and disclose antithrombotic properties. Observational studies from Mediterranean cohorts have suggested that dietary MUFA may be protective against age-related cognitive decline and Alzheimer's disease. Recent studies consistently support the concept that the OO-rich MedDiet is compatible with healthier aging and increased longevity. In countries where the population adheres to the MedDiet, such as Spain, Greece and Italy, and OO is the principal source of fat, rates of cancer incidence are lower than in northern European countries. Experimental and human cellular studies have provided new evidence on the potential protective effect of OO on cancer. Furthermore, results of case-control and cohort studies suggest that MUFA intake including OO is associated with a reduction in cancer risk (mainly breast, colorectal and prostate cancers). (C) 2009 Elsevier B.V. All rights reserved.
C1 [Lopez-Miranda, J.] Reina Sofia Univ Hosp, Dept Med, Lipid & Atherosclerosis Unit, Sch Med, Cordoba 14004, Spain.
   [Ros, E.; Estruch, R.] Hosp Clin Barcelona, Inst Invest Biomed August Pi Sunyer, Barcelona, Spain.
   [De Caterina, R.] Univ G DAnnunzio, Inst Cardiol, Chieti, Italy.
   [Badimon, L.] CSIC, Barcelona, Spain.
   [Covas, M. I.; de la Torre-Fornell, R.] Inst Municipal Invest Med, E-08003 Barcelona, Spain.
   [Escrich, E.; Solanas, M.] Univ Autonoma Barcelona, Barcelona, Spain.
   [Ordovas, J. M.] Tufts Univ, USDA, Human Nutr Res Ctr Aging, Boston, MA 02111 USA.
   [Soriguer, F.] Carlos Haya Univ Hosp, Malaga, Spain.
   [Abia, R.; Muriana, F. J.; Perona, J.] CSIC, Inst Grasa, E-41080 Seville, Spain.
   [Alarcon de la Lastra, C.] Univ Seville, Dept Pharmacol, Seville, Spain.
   [Battino, M.] Univ Politecn Marche Ancona, Dept Biochem Biol & Genet, Ancona, Italy.
   [Corella, D.] Univ Valencia, Dept Prevent Med & Publ Hlth, Valencia, Spain.
   [Corella, D.] Univ Valencia, C1BEROBN, Valencia, Spain.
   [Chamorro-Quiros, J.] Hosp Ciudad Jaen, Jaen, Spain.
   [Giugliano, D.; Esposito, K.] Univ Naples SUN, Ctr Excellence Cardiovasc Dis, Naples, Italy.
   [Fernandez-Real, J. M.] Hosp Josep Trueta, Dept Endocrinol, Girona, Spain.
   [Gaforio, J. J.] Univ Jaen, Dept Hlth Sci, Jaen, Spain.
   [La Vecchia, C.] Ist Ric Farmacol, Milan, Italy.
   [Lairon, D.] Univ Mediterranee, INRA, Fac Med, INSERM,U476,UMR 1260, Marseille, France.
   [Mata, P.] Fdn Jimenez Diaz, E-28040 Madrid, Spain.
   [Menendez, J. A.] Inst Catalan Oncol, Girona, Spain.
   [Osada, J.] Univ Zaragoza, Dept Biochem & Mol Biol, E-50009 Zaragoza, Spain.
   [Panagiotakos, D. B.; Villalba-Montoro, J. M.] Harokopio Univ Athens, Dept Nutr & Dietet, Athens, Greece.
   [Peinado, M. A.] Univ Jaen, Dept Expt Biol, Jaen, Spain.
   [Pineda-Priego, M.] Univ Cordoba, E-14071 Cordoba, Spain.
   [Poulsen, H. E.] Univ Copenhagen Hosp, Rigshosp, Dept Clin Pharmacol, DK-2100 Copenhagen, Denmark.
   [Quiles, J. L.; Ramirez-Tortosa, M. C.] Univ Granada, Dept Physiol, E-18071 Granada, Spain.
   [Serra-Majem, L.] Univ Las Palmas Gran Canaria, Dept Clin Sci, Las Palmas Gran Canaria, Spain.
   [Sola, R.] Univ Rovira & Virgili, Hosp Univ St Joan, CIBERDEM, IISPV, Tarragona, Spain.
   [Solfrizzi, V.] Univ Bari, Memory Unit, Ctr Aging Brain, Dept Geriatr, Bari, Italy.
   [Trichopoulou, A.] Univ Athens, Sch Med, Dept Hyg & Epidemiol, GR-11527 Athens, Greece.
   [Uceda, M.] IFAPA Ctr Venta del Llano, Jaen, Spain.
   [Villar-Ortiz, J. R.] Univ Seville, Virgen del Rocio Univ Hosp, Seville, Spain.
   [Visioli, F.] Univ Paris 06, UMR7079, Paris 5, France.
C3 Hospital Universitario Reina Sofia - Cordoba; University of Barcelona;
   Hospital Clinic de Barcelona; IDIBAPS; G d'Annunzio University of
   Chieti-Pescara; Consejo Superior de Investigaciones Cientificas (CSIC);
   Autonomous University of Barcelona; United States Department of
   Agriculture (USDA); Tufts University; Hospital Carlos Haya; Consejo
   Superior de Investigaciones Cientificas (CSIC); CSIC - Instituto de la
   Grasa (IG); University of Sevilla; Marche Polytechnic University;
   University of Valencia; University of Valencia; Universitat de Girona;
   Girona University Hospital Dr. Josep Trueta; Universidad de Jaen;
   Aix-Marseille Universite; Institut National de la Sante et de la
   Recherche Medicale (Inserm); INRAE; Institut Catala d'Oncologia;
   University of Zaragoza; Harokopio University Athens; Universidad de
   Jaen; Universidad de Cordoba; Rigshospitalet; University of Copenhagen;
   Copenhagen University Hospital; University of Granada; Universidad de
   Las Palmas de Gran Canaria; Universitat Rovira i Virgili; Institut
   d'Investigacio Sanitaria Pere Virgili (IISPV); CIBER - Centro de
   Investigacion Biomedica en Red; CIBERDEM; Universita degli Studi di Bari
   Aldo Moro; Athens Medical School; National & Kapodistrian University of
   Athens; Virgen del Rocio University Hospital; University of Sevilla;
   Sorbonne Universite
RP López-Miranda, J (corresponding author), Reina Sofia Univ Hosp, Dept Med, Lipid & Atherosclerosis Unit, Sch Med, Avda Menendez Pidal S-N, Cordoba 14004, Spain.
EM jlopezmir@uco.es; fperezjimenez@uco.es; eros@clinic.ub.es
RI Fernández-Real, Jose Manuel/AGH-3599-2022; solfrizzi,
   vincenzo/AAL-3222-2020; Serra-Majem, Lluis/I-6708-2019; TRICHOPOULOU,
   ANTONIA/ABF-8727-2021; Panagiotakos, Demosthenes/K-8294-2019; De
   Caterina, Raffaele/K-3857-2016; Esposito, Katherine/AHE-2564-2022;
   Casas, Rosa/ABD-1915-2020; Garcia, Montserrat/O-4684-2016; Muriana,
   Francisco/S-1825-2016; SOLÀ, Rosa/N-5919-2014; de la Torre,
   Rafael/D-3561-2018; La Vecchia, Carlo/Z-1710-2019; Jimenez,
   Francisco/AAJ-9559-2021; Lopez-Miranda, Jose/Y-8306-2019; BADIMON,
   LINA/S-2950-2019; YIANNAKOURIS, NIKOS/AAL-7123-2021; Delgado-Lista,
   Javier/KAM-7412-2024; Perona, Javier/K-9201-2019; Corella,
   Dolores/L-9888-2014; Ruano, Juan/T-1991-2018; Perez Martinez,
   Pablo/AEL-6176-2022; Ordovas, Jose/B-8727-2013; Visioli,
   Francesco/J-9356-2013; Battino, Maurizio/E-6103-2012; Perona,
   Javier/B-9721-2014; MENENDEZ MENENDEZ, JAVIER ABEL/C-6148-2016;
   Alarcon-de-la-Lastra, Catalina/F-6282-2013; Abia, Rocio/P-1678-2016;
   Quiles, Jose L./C-6911-2013; Badimon, Lina/O-4711-2014
OI Ros, Emilio/0000-0002-2573-1294; Perez Martinez,
   Pablo/0000-0001-7716-8117; Ordovas, Jose/0000-0002-7581-5680;
   Lopez-Miranda, Jose/0000-0002-8844-0718; Fernandez-Real, Jose
   Manuel/0000-0002-7442-9323; Delgado Lista, Francisco
   Javier/0000-0002-2982-2716; Visioli, Francesco/0000-0002-1756-1723;
   Serra-Majem, Lluis/0000-0002-9658-9061; Battino,
   Maurizio/0000-0002-7250-1782; Peinado, Maria
   Angeles/0000-0003-3136-0706; Lairon, Denis/0000-0001-9941-3742; SOLA,
   Rosa/0000-0002-8359-235X; Gaforio, Jose J/0000-0003-2996-9301; Ruano,
   Juan/0000-0002-0286-4107; Perona, Javier/0000-0001-5919-993X; MENENDEZ
   MENENDEZ, JAVIER ABEL/0000-0001-8733-4561; Alarcon-de-la-Lastra,
   Catalina/0000-0001-6625-3818; Abia, Rocio/0000-0003-2741-189X;
   Giugliano, Dario/0000-0002-9377-873X; de la Torre,
   Rafael/0000-0002-6765-1866; Casas, Rosa/0000-0002-0211-9166; SOLANAS
   GARCIA, MONTSERRAT/0000-0003-2949-1344; Perez Jimenez,
   Francisco/0000-0001-9808-1280; Perez-Jimenez,
   Francisco/0000-0001-7499-7681; Quiles, Jose L./0000-0002-9048-9086;
   Yiannakouris, Nikos/0000-0003-3269-4919; Poulsen, Henrik
   Enghusen/0000-0003-4242-9924; , Juan A. Paniagua/0000-0003-2892-980X;
   Badimon, Lina/0000-0002-9162-2459; La Vecchia, Carlo/0000-0003-1441-897X
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NR 105
TC 430
Z9 451
U1 1
U2 197
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0939-4753
EI 1590-3729
J9 NUTR METAB CARDIOVAS
JI Nutr. Metab. Carbiovasc. Dis.
PD MAY
PY 2010
VL 20
IS 4
BP 284
EP 294
DI 10.1016/j.numecd.2009.12.007
PG 11
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism; Nutrition
   & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism;
   Nutrition & Dietetics
GA 612IU
UT WOS:000278891900009
PM 20303720
DA 2025-06-11
ER

PT J
AU Al-Solaiman, Y
   Jesri, A
   Mountford, WK
   Lackland, DT
   Zhao, Y
   Egan, BM
AF Al-Solaiman, Y.
   Jesri, A.
   Mountford, W. K.
   Lackland, D. T.
   Zhao, Y.
   Egan, B. M.
TI DASH lowers blood pressure in obese hypertensives beyond potassium,
   magnesium and fibre
SO JOURNAL OF HUMAN HYPERTENSION
LA English
DT Article
DE blood pressure; Dietary Approaches to Stop Hypertension; metabolic
   syndrome; potassium; magnesium; fibre
ID NITRIC-OXIDE SYNTHASE; OXIDATIVE STRESS; ENDOTHELIAL FUNCTION; ARTERIAL
   STIFFNESS; METABOLIC SYNDROME; VITAMIN-C; DEPENDENT VASODILATION;
   DOUBLE-BLIND; FOLIC-ACID; US ADULTS
AB The mechanism underlying blood pressure (BP) reduction in the high fruits and vegetables arm of the Dietary Approaches to Stop Hypertension (DASH) study is unknown but may include potassium, magnesium and fibre. This study was designed to separate minerals and fibre from other components of DASH on BP in abdominally obese individuals with metabolic syndrome with pre-hypertension to stage 1 hypertension (obese hypertensives). A total of 15 obese hypertensives and 15 lean normotensives were studied on a standardized usual diet, randomized to DASH or usual diet supplemented with potassium, magnesium and fibre to match DASH, then crossed over to the complementary diet. All diets were 3 weeks long, isocaloric and matched for sodium and calcium. In obese hypertensives, BP was lower after 3 weeks on DASH than usual diet (-7.6 +/- 1.4/-5.3 +/- 1.4mmHg, P<0.001/0.02) and usual diet supplemented (-6.2 +/- 1.4/-3.7 +/- 1.4 P<0.005/0.06), whereas BP was not significantly different on usual and supplemented diets. BP values were not different among the three diets in lean normotensives. Small artery elasticity was lower in obese hypertensives than in lean normotensives on the usual and supplemented diets (P<0.02). This index of endothelial function improved in obese hypertensives (P<0.02) but not lean normotensives on DASH, and was no longer different from values in lean normotensives (P>0.50). DASH is more effective than potassium, magnesium and fibre supplements for lowering BP in obese hypertensives, which suggest that high fruits and vegetables DASH lowers BP and improves endothelial function in this group by nutritional factors in addition to potassium, magnesium and fibre. Journal of Human Hypertension (2010) 24, 237-246; doi:10.1038/jhh.2009.58; published online 23 July 2009
C1 [Al-Solaiman, Y.; Jesri, A.; Mountford, W. K.; Lackland, D. T.; Zhao, Y.; Egan, B. M.] MUSC, Dept Med, Charleston, SC 29425 USA.
C3 Medical University of South Carolina
RP Egan, BM (corresponding author), MUSC, Dept Med, 135 Rutledge Ave,RT 1230, Charleston, SC 29425 USA.
EM eganbm@musc.edu
FU National Institutes of Health [HL58794, HL04290]; National Center for
   Minority Health and Disparities [MD00267]; Division of Research
   Resources [RR-01070]
FX We thank Kelley Martin, RD, MS, General Clinical Research Nutritionist,
   for her extraordinary efforts in assisting volunteers to comply with the
   study diets. We also thank the entire General Clinical Research Center
   staff for their dedication to the integrity of the research protocol as
   well as Kim Edwards for administrative support. This research was
   supported by grants from the National Institutes of Health (HL58794,
   HL04290), MD00267 from the National Center for Minority Health and
   Disparities, and the General Clinical Research Center (RR-01070) from
   the Division of Research Resources.
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NR 56
TC 88
Z9 103
U1 1
U2 15
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0950-9240
EI 1476-5527
J9 J HUM HYPERTENS
JI J. Hum. Hypertens.
PD APR
PY 2010
VL 24
IS 4
BP 237
EP 246
DI 10.1038/jhh.2009.58
PG 10
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 570IJ
UT WOS:000275666500003
PM 19626043
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Martin-Cordero, L
   Garcia, JJ
   Giraldo, E
   De la Fuente, M
   Manso, R
   Ortega, E
AF Martin-Cordero, L.
   Garcia, J. J.
   Giraldo, E.
   De la Fuente, M.
   Manso, R.
   Ortega, E.
TI Influence of exercise on the circulating levels and macrophage
   production of IL-1β and IFNγ affected by metabolic syndrome: an obese
   Zucker rat experimental animal model
SO EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
LA English
DT Article
DE Exercise; Metabolic syndrome; Obesity; Inflammation; Macrophages; Zucker
   rats
ID NECROSIS-FACTOR-ALPHA; PHYSICAL-ACTIVITY; PERITONEAL-MACROPHAGES;
   ADIPOSE-TISSUE; INSULIN SENSITIVITY; INDUCED STIMULATION;
   GENE-EXPRESSION; PLASMA-LEVELS; INFLAMMATION; STRESS
AB Regular physical activity is recognized as a non-pharmacological treatment of genetic obesity and typeII diabetes, and based on the "anti-inflammatory" effects of exercise, it has been also proposed for improving the "chronic low-grade inflammation" in metabolic syndrome (MS). The aim of the present work was to evaluate the effects of an habitual exercise program (running, 5 days/week for 35 min at 35 cm/s for 14 weeks) and of a bout of acute exercise (running, for 35 min at 35 cm/s) on MS-associated disorders in the pro-inflammatory cytokines IL-1 beta and IFN gamma. The study was carried out on obese Zucker rats (fa/fa). The obese rats presented higher circulating concentrations and constitutive macrophage production (in the absence of antigenic stimulus) of IL-1 beta (but not of IFN gamma). But their production of both IL-1 beta and IFN gamma by lipopolysaccharide (LPS)-stimulated macrophages was lower than that of the control lean rats. Our protocol of exercise training did not modify the circulating concentration and constitutive macrophage release of either IL-1 beta or IFN gamma in the obese rats, but increased the production of both cytokines by LPS-stimulated macrophages. The single bout of acute exercise only increased the release of IL-1 beta by the LPS-stimulated macrophages from obese rats, in both sedentary and trained animals. The results indicated that: (1) circulating levels and constitutive production of IL-1 beta by macrophages are deregulated in rats with MS, and (2) IL-1 beta and IFN gamma production by macrophages in response to antigenic stimulus (LPS) is impaired in the obese animals, and this MS-associated disorder is improved by the program of habitual exercise training.
C1 [Martin-Cordero, L.; Garcia, J. J.; Giraldo, E.; Ortega, E.] Univ Extremadura, Dept Physiol, Fac Sci, E-06071 Badajoz, Spain.
   [De la Fuente, M.] Univ Complutense, Dept Physiol, Fac Biol, E-28040 Madrid, Spain.
   [Manso, R.] Severo Ochoa CSIC UAM, Dept Mol Biol, Madrid, Spain.
   [Manso, R.] Severo Ochoa CSIC UAM, Ctr Mol Biol, Madrid, Spain.
C3 Universidad de Extremadura; Complutense University of Madrid; Consejo
   Superior de Investigaciones Cientificas (CSIC); Consejo Superior de
   Investigaciones Cientificas (CSIC)
RP Ortega, E (corresponding author), Univ Extremadura, Dept Physiol, Fac Sci, E-06071 Badajoz, Spain.
EM orincon@unex.es
RI Garcia, Juan/C-7383-2013; Martin-Cordero, Leticia/H-9711-2015; Ortega,
   Eduardo/H-9891-2016; Giraldo, Esther/AAU-2995-2021
OI Garcia, Juan/0000-0002-8222-4213; Martin-Cordero,
   Leticia/0000-0002-3651-2265; Ortega, Eduardo/0000-0002-7007-7615;
   Giraldo, Esther/0000-0001-5488-3011
FU Ministry of Science and Innovation [DEP2006-56187-C04-03]; Junta de
   Extremadura; Fundacion Valhondo de Extremadura, Spain
FX This work was partially supported by grants DEP2006-56187-C04-03
   (Ministry of Science and Innovation), GRU08039 (Junta de Extremadura)
   and Fundacion Valhondo de Extremadura, Spain. The experiment was
   approved by the Ethical Committees of the Autonoma University (Madrid,
   Spain) and of the University of Extremadura (Badajoz, Spain) according
   to the guidelines of the European Community Council Directives and the
   Declaration of Helsinki.
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NR 47
TC 30
Z9 35
U1 0
U2 7
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1439-6319
EI 1439-6327
J9 EUR J APPL PHYSIOL
JI Eur. J. Appl. Physiol.
PD NOV
PY 2009
VL 107
IS 5
BP 535
EP 543
DI 10.1007/s00421-009-1140-4
PG 9
WC Physiology; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology; Sport Sciences
GA 511VN
UT WOS:000271199300005
PM 19688220
DA 2025-06-11
ER

PT J
AU Sun, WD
   Zhu, XJ
   Li, JJ
   Mei, YZ
   Li, WS
   Li, JH
AF Sun, Wei-Dong
   Zhu, Xiao-Juan
   Li, Jing-Jing
   Mei, Ya-Zhong
   Li, Wen-Song
   Li, Jiang-Hua
TI Nicotinamide N-methyltransferase (NNMT): a novel therapeutic target for
   metabolic syndrome
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Review
DE nicotinamide N-methyltransferase (NNMT); metabolic syndrome (MetS);
   nicotinamide adenine dinucleotide (NAD(+)); homocysteine (Hcy); obesity;
   diabetes; hyperlipidemia; hypertension
ID INCREASED OXIDATIVE STRESS; SMALL-MOLECULE INHIBITORS; MESENCHYMAL
   STEM-CELL; ADIPOSE-TISSUE; ENDOTHELIAL DYSFUNCTION; PRIMARY
   HYPERTENSION; NAD(+) BIOSYNTHESIS; HYDROGEN-SULFIDE; INTERFERING RNAS;
   LIPID-METABOLISM
AB Metabolic syndrome (MetS) represents a constellation of metabolic abnormalities, typified by obesity, hypertension, hyperglycemia, and hyperlipidemia. It stems from intricate dysregulations in metabolic pathways governing energy and substrate metabolism. While comprehending the precise etiological mechanisms of MetS remains challenging, evidence underscores the pivotal roles of aberrations in lipid metabolism and insulin resistance (IR) in its pathogenesis. Notably, nicotinamide N-methyltransferase (NNMT) has recently surfaced as a promising therapeutic target for addressing MetS. Single nucleotide variants in the NNMT gene are significantly correlated with disturbances in energy metabolism, obesity, type 2 diabetes (T2D), hyperlipidemia, and hypertension. Elevated NNMT gene expression is notably observed in the liver and white adipose tissue (WAT) of individuals with diabetic mice, obesity, and rats afflicted with MetS. Knockdown of NNMT elicits heightened energy expenditure in adipose and hepatic tissues, mitigates lipid accumulation, and enhances insulin sensitivity. NNMT catalyzes the methylation of nicotinamide (NAM) using S-adenosyl-methionine (SAM) as the donor methyl group, resulting in the formation of S-adenosyl-l-homocysteine (SAH) and methylnicotinamide (MNAM). This enzymatic process results in the depletion of NAM, a precursor of nicotinamide adenine dinucleotide (NAD(+)), and the generation of SAH, a precursor of homocysteine (Hcy). Consequently, this cascade leads to reduced NAD(+) levels and elevated Hcy levels, implicating NNMT in the pathogenesis of MetS. Moreover, experimental studies employing RNA interference (RNAi) strategies and small molecule inhibitors targeting NNMT have underscored its potential as a therapeutic target for preventing or treating MetS-related diseases. Nonetheless, the precise mechanistic underpinnings remain elusive, and as of yet, clinical trials focusing on NNMT have not been documented. Therefore, further investigations are warranted to elucidate the intricate roles of NNMT in MetS and to develop targeted therapeutic interventions.
C1 [Sun, Wei-Dong; Zhu, Xiao-Juan; Li, Jing-Jing; Mei, Ya-Zhong; Li, Wen-Song; Li, Jiang-Hua] Jiangxi Normal Univ, Phys Educ Coll, Key Lab Aquat Training Monitoring & Intervent Gen, Nanchang, Peoples R China.
C3 Jiangxi Normal University
RP Li, JH (corresponding author), Jiangxi Normal Univ, Phys Educ Coll, Key Lab Aquat Training Monitoring & Intervent Gen, Nanchang, Peoples R China.
EM lijianghua8@sina.com
RI li, jianghua/GXG-4735-2022
OI Li, Jiang-Hua/0000-0001-9221-0387; Sun, Wei-Dong/0009-0005-2981-4176
FU National Natural Science Foundation of China10.13039/501100001809
FX No Statement Available
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NR 174
TC 8
Z9 8
U1 2
U2 13
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD JUN 11
PY 2024
VL 15
AR 1410479
DI 10.3389/fphar.2024.1410479
PG 17
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA WD7N3
UT WOS:001252997700001
PM 38919254
OA gold
DA 2025-06-11
ER

PT J
AU Jackson, TW
   Ryherd, GL
   Scheibly, CM
   Sasser, AL
   Guillette, TC
   Belcher, SM
AF Jackson, Thomas W.
   Ryherd, Garret L.
   Scheibly, Chris M.
   Sasser, Aubrey L.
   Guillette, T. C.
   Belcher, Scott M.
TI Gestational Cd Exposure in the CD-1 Mouse Induces Sex-Specific Hepatic
   Insulin Insensitivity, Obesity, and Metabolic Syndrome in Adult Female
   Offspring
SO TOXICOLOGICAL SCIENCES
LA English
DT Article
DE cadmium; diabetes mellitus type 2; endocrine disruption; insulin
   resistance; metabolic; nonalcoholic fatty liver disease; retinoic acid
ID BIOLOGICAL HALF-LIFE; FATTY LIVER-DISEASE; CADMIUM EXPOSURE; RETINOIC
   ACID; HEPATOCELLULAR-CARCINOMA; MATERNAL EXPOSURE; DNA METHYLATION;
   URINARY CADMIUM; ZINC; ASSOCIATION
AB There is compelling evidence that developmental exposure to toxic metals increases risk for obesity and obesity-related morbidity including cardiovascular disease and type 2 diabetes. To explore the hypothesis that developmental Cd exposure increases risk of obesity later in life, male, and female CD-1 mice were maternally exposed to 500 ppb CdCl2 in drinking water during a human gestational equivalent period (gestational day 0-postnatal day 10 [GD0-PND10]). Hallmark indicators of metabolic disruption, hepatic steatosis, and metabolic syndrome were evaluated prior to birth through adulthood. Maternal blood Cd levels were similar to those observed in human pregnancy cohorts, and Cd was undetected in adult offspring. There were no observed impacts of exposure on dams or pregnancy-related outcomes. Results of glucose and insulin tolerance testing revealed that Cd exposure impaired offspring glucose homeostasis on PND42. Exposure-related increases in circulating triglycerides and hepatic steatosis were apparent only in females. By PND120, Cd-exposed females were 30% heavier with 700% more perigonadal fat than unexposed control females. There was no evidence of dyslipidemia, steatosis, increased weight gain, nor increased adiposity in Cd-exposed male offspring. Hepatic transcriptome analysis on PND1, PND21, and PND42 revealed evidence for female-specific increases in oxidative stress and mitochondrial dysfunction with significant early disruption of retinoic acid signaling and altered insulin receptor signaling consistent with hepatic insulin sensitivity in adult females. The observed steatosis and metabolic syndrome-like phenotypes resulting from exposure to 500 ppb CdCl2 during the pre- and perinatal period of development equivalent to human gestation indicate that Cd acts developmentally as a sex-specific delayed obesogen.
C1 [Jackson, Thomas W.; Ryherd, Garret L.; Scheibly, Chris M.; Sasser, Aubrey L.; Guillette, T. C.; Belcher, Scott M.] North Carolina State Univ, Dept Biol Sci, Ctr Human Hlth & Environm, 127 David Clark Labs Campus Box 7617, Raleigh, NC 27695 USA.
C3 North Carolina State University
RP Belcher, SM (corresponding author), North Carolina State Univ, Dept Biol Sci, Ctr Human Hlth & Environm, 127 David Clark Labs Campus Box 7617, Raleigh, NC 27695 USA.
EM smbelch2@ncsu.edu
RI Jackson, Thomas/AIC-9702-2022
OI Sasser, Aubrey Lyn/0000-0001-5189-9720; Jackson,
   Thomas/0000-0002-7996-0412; Belcher, Scott/0000-0002-1196-3705;
   Guillette, Theresa/0000-0003-1790-5108
FU NIEHS [5T32ES007046-38, P30ES025128]
FX This work was supported in part by NIEHS training grant 5T32ES007046-38
   and NIEHS award P30ES025128. We are grateful to Dr. Catherine Hoyo and
   Sandy Elliott for their collaboration and dedicated commitment to the
   success of these studies.
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NR 126
TC 21
Z9 25
U1 0
U2 19
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1096-6080
EI 1096-0929
J9 TOXICOL SCI
JI Toxicol. Sci.
PD DEC
PY 2020
VL 178
IS 2
BP 264
EP 280
DI 10.1093/toxsci/kfaa154
PG 17
WC Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Toxicology
GA PT1QQ
UT WOS:000608394200005
PM 33259630
OA Green Published
DA 2025-06-11
ER

PT J
AU Xuan, LL
   Han, FF
   Gong, LL
   Lv, YL
   Wan, ZR
   Liu, H
   Zhang, DS
   Jia, YJ
   Yang, S
   Ren, LL
   Liu, LH
AF Xuan, Lingling
   Han, Feifei
   Gong, Lili
   Lv, Yali
   Wan, Zirui
   Liu, He
   Zhang, Dongsu
   Jia, Yangjie
   Yang, Song
   Ren, Lulu
   Liu, Lihong
TI Association between chronic obstructive pulmonary disease and serum
   lipid levels: a meta-analysis
SO LIPIDS IN HEALTH AND DISEASE
LA English
DT Article
DE COPD; dyslipidemia; high-density lipoprotein cholesterol; low-density
   lipoprotein cholesterol; total cholesterol; triglyceride
ID METABOLIC SYNDROME; SYSTEMIC INFLAMMATION; PHYSICAL-ACTIVITY; OXIDATIVE
   STRESS; LUNG-FUNCTION; COPD; POPULATION; PREVALENCE; FREQUENCY; OBESITY
AB Background: Metabolic syndrome is a common extrapulmonary comorbidity in patients with chronic obstructive pulmonary disease (COPD). However, the reported relationship of COPD with dyslipidemia, an important component of metabolic syndrome, is ambiguous. The aim of this meta-analysis is to investigate the association between COPD and the serum levels of high-density lipoprotein cholesterol (HDL), low-density lipoprotein cholesterol (LDL), total cholesterol (TC), and triglyceride (TG).
   Methods: The PubMed and Embase databases were searched to find potential studies using the search terms of ("dyslipidemia" or "HDL" or "LDL" or "cholesterol" or "triglyceride") and COPD. We also performed subgroup analysis enrolling patients who were not receiving treatment for dyslipidemia. Mean differences (MD) with 95% confidence intervals (CI) were estimated with random effects models.
   Results: A total of 11 studies comprising 615 cases and 471 controls were included in the study. No significant differences were found in the HDL (MD = -2.55, 95% CI [-6.03, 0.93], P = 0.15), LDL (MD = -2.25, 95% CI [-13.36, 8.86], P = 0.69), TC (MD = -2.69, 95% CI [-13.30, 7.92], P = 0.62), and TG (MD = 6.90, 95% CI [-2.81, 16.60], P = 0.16) levels of the 2 groups. However, subgroup analysis enrolling patients who were not receiving treatment for dyslipidemia showed that TG levels were higher in patients with stable COPD than in healthy individuals (MD = 16.35, 95% CI [5.90, 26.80], P = 0.002).
   Conclusions: Excluding the impact of hypolipidemic treatment on serum lipid profile, TG levels were higher in patients with COPD than in healthy individuals. This meta-analysis suggested that physicians should screen COPD patients for elevated TG levels to reduce the risk of cardiovascular morbidity and mortality.
C1 [Xuan, Lingling; Han, Feifei; Gong, Lili; Lv, Yali; Wan, Zirui; Liu, He; Zhang, Dongsu; Jia, Yangjie; Yang, Song; Ren, Lulu; Liu, Lihong] Capital Med Univ, Beijing Chao Yang Hosp, Dept Pharm, Beijing, Peoples R China.
C3 Capital Medical University
RP Liu, LH (corresponding author), Capital Med Univ, Beijing Chao Yang Hosp, Dept Pharm, Beijing, Peoples R China.
EM xuanlinglinghd@163.com; liulihong@bjcyh.com
RI Gong, Lili/F-8452-2014
FU Scientific Research Foundation of Capital Medical University
   [3500-1182080843]; Beijing Chao-Yang Hospital 1351 programme
   [CYXX-2017-32]
FX This study was supported by Scientific Research Foundation of Capital
   Medical University (NO. 3500-1182080843) and Beijing Chao-Yang Hospital
   1351 programme (NO. CYXX-2017-32).
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NR 34
TC 47
Z9 48
U1 1
U2 11
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1476-511X
J9 LIPIDS HEALTH DIS
JI Lipids Health Dis.
PD NOV 21
PY 2018
VL 17
AR 263
DI 10.1186/s12944-018-0904-4
PG 8
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA HB3ID
UT WOS:000450943500001
PM 30463568
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Yamada, Y
   Takeuchi, S
   Yoneda, M
   Ito, S
   Sano, Y
   Nagasawa, K
   Matsuura, N
   Uchinaka, A
   Murohara, T
   Nagata, K
AF Yamada, Yuichiro
   Takeuchi, Shino
   Yoneda, Mamoru
   Ito, Shogo
   Sano, Yusuke
   Nagasawa, Kai
   Matsuura, Natsumi
   Uchinaka, Ayako
   Murohara, Toyoaki
   Nagata, Kohzo
TI Atorvastatin reduces cardiac and adipose tissue inflammation in rats
   with metabolic syndrome
SO INTERNATIONAL JOURNAL OF CARDIOLOGY
LA English
DT Article
DE Metabolic syndrome; Inflammation; AMP-activated protein kinase; Nuclear
   factor-kappa B; Atorvastatin
ID ACTIVATED-PROTEIN-KINASE; COA REDUCTASE INHIBITOR; NF-KAPPA-B;
   ANIMAL-MODEL; DAHLS.Z-LEPR(FA)/LEPR(FA) RATS; DIASTOLIC DYSFUNCTION;
   INSULIN-RESISTANCE; HEART; PRAVASTATIN; PATHOLOGY
AB Background: Statins are strong inhibitors of cholesterol biosynthesis and help to prevent cardiovascular disease. They also exert additional pleiotropic effects that include an anti-inflammatory action and are independent of cholesterol, but the molecular mechanisms underlying these additional effects have remained unclear. We have now examined the effects of atorvastatin on cardiac and adipose tissue inflammation in DahlS.Z-Lepr(fa)/Lepr(fa) (DS/obese) rats, which we previously established as a model of metabolic syndrome (MetS).
   Methods and results: DS/obese rats were treated with atorvastatin (6 or 20 mg kg(-1) day(-1)) from 9 to 13 weeks of age. Atorvastatin ameliorated cardiac fibrosis, diastolic dysfunction, oxidative stress, and inflammation as well as adipose tissue inflammation in these animals at both doses. The high dose of atorvastatin reduced adipocyte hypertrophy to a greater extent than did the low dose. Atorvastatin inhibited the up-regulation of peroxisome proliferator-activated receptor gamma gene expression in adipose tissue as well as decreased the serum adiponectin concentration in DS/obese rats. It also activated AMP-activated protein kinase (AMPK) as well as inactivated nuclear factor-kappa B (NF-kappa B) in the heart of these animals. The down-regulation of AMPK and NF-kappa B activities in adipose tissue of DS/obese rats was attenuated and further enhanced, respectively, by atorvastatin treatment.
   Conclusions: The present results suggest that the anti-inflammatory effects of atorvastatin on the heart and adipose tissue are attributable at least partly to increased AMPK activity and decreased NF-kappa B activity in this rat model of MetS. (C) 2017 Elsevier B.V. All rights reserved.
C1 [Yamada, Yuichiro; Yoneda, Mamoru; Ito, Shogo; Sano, Yusuke; Nagasawa, Kai; Matsuura, Natsumi; Uchinaka, Ayako; Nagata, Kohzo] Nagoya Univ, Grad Sch Med, Dept Pathophysiol Lab Sci, Nagoya, Aichi, Japan.
   [Takeuchi, Shino] Nagoya Univ, Sch Hlth Sci, Dept Med Technol, Nagoya, Aichi, Japan.
   [Murohara, Toyoaki] Nagoya Univ, Grad Sch Med, Dept Cardiol, Nagoya, Aichi, Japan.
C3 Nagoya University; Nagoya University; Nagoya University
RP Nagata, K (corresponding author), Nagoya Univ, Grad Sch Med, Dept Pathophysiol Lab Sci, Higashi Ku, 1-1-20 Daikominami, Nagoya, Aichi 4618673, Japan.
EM nagata@met.nagoya-u.ac.jp
FU Kyowa Hakko Kirin Co. Ltd. (Tokyo, Japan); Ajinomoto Pharmaceuticals Co.
   Ltd. (Tokyo, Japan); Takeda Pharmaceutical Co., Ltd. (Osaka, Japan); MSD
   in Japan (Tokyo, Japan); Daiichi-Sankyo Co. Ltd. (Tokyo, Japan);
   Astellas Pharma Inc. (Tokyo, Japan)
FX This work was supported by unrestricted grants from Kyowa Hakko Kirin
   Co. Ltd. (Tokyo, Japan), Ajinomoto Pharmaceuticals Co. Ltd. (Tokyo,
   Japan), Takeda Pharmaceutical Co., Ltd. (Osaka, Japan), MSD in Japan
   (Tokyo, Japan), Daiichi-Sankyo Co. Ltd. (Tokyo, Japan), Astellas Pharma
   Inc. (Tokyo, Japan), and Dr. Kohzo Nagata (Nagoya University).
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NR 45
TC 37
Z9 39
U1 1
U2 12
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0167-5273
EI 1874-1754
J9 INT J CARDIOL
JI Int. J. Cardiol.
PD AUG 1
PY 2017
VL 240
BP 332
EP 338
DI 10.1016/j.ijcard.2017.04.103
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA FA5AK
UT WOS:000405454800061
PM 28499669
DA 2025-06-11
ER

PT J
AU Suslova, TE
   Sitozhevskii, AV
   Ogurkova, ON
   Kravchenko, ES
   Kologrivova, IV
   Anfinogenova, Y
   Karpov, RS
AF Suslova, Tatiana E.
   Sitozhevskii, Alexei V.
   Ogurkova, Oksana N.
   Kravchenko, Elena S.
   Kologrivova, Irina V.
   Anfinogenova, Yana
   Karpov, Rostislav S.
TI Platelet hemostasis in patients with metabolic syndrome and type 2
   diabetes mellitus: cGMP- and NO-dependent mechanisms in the
   insulin-mediated platelet aggregation
SO FRONTIERS IN PHYSIOLOGY
LA English
DT Article
DE platelets; metabolic syndrome; type 2 diabetes mellitus; nitric oxide;
   nitric oxide synthase; cyclic guanosine monophosphate
ID NITRIC-OXIDE SYNTHASE; TUMOR-NECROSIS-FACTOR; IN-VIVO; VASCULAR-DISEASE;
   FACTOR-ALPHA; OBESE NIDDM; RESISTANCE; HOMOCYSTEINE; INHIBITION;
   ACTIVATION
AB Patients with metabolic syndrome (MetS) and type 2 diabetes mellitus (T2DM) have high risk of microcirculation complications and microangiopathies. An increase in thrombogenic risk is associated with platelet hyperaggregation, hypercoagulation, and hyperfibrinolysis. Factors leading to platelet activation in MetS and T2DM comprise insulin resistance, hyperglycemia, non-enzymatic glycosylation, oxidative stress, and inflammation. This review discusses the role of nitric oxide (NO) in the regulation of platelet adhesion and aggregation processes. NO is synthesized both in endotheliocytes, smooth muscle cells, macrophages, and platelets. Modification of platelet NO-synthase (NOS) activity in MetS patients can play a central role in the manifestation of platelet hyperactivation. Metabolic changes, accompanying T2DM, can lead to an abnormal NOS expression and activity in platelets. Hyperhomocysteinemia, often accompanying T2DM, is a risk factor for cardiovascular accidents. Homocysteine can reduce NO production by platelets. This review provides data on the insulin effects in platelets. Decrease in a number and sensitivity of the insulin receptors on platelets in T2DM can cause platelet hyperactivation. Various intracellular mechanisms of anti-aggregating insulin effects are discussed. Anti-aggregating effects of insulin are mediated by a NO-induced elevation of cGMP and upregulation of cAMP- and cGMP-dependent pathways. The review presents data suggesting an ability of platelets to synthesize humoral factors stimulating thrombogenesis and inflammation. Proinflammatory cytokines are considered as markers of T2DM and cardiovascular complications and are involved in the development of dyslipidemia and insulin resistance. The article provides an evaluation of NO-mediated signaling pathway in the effects of cytokines on platelet aggregation. The effects of the proinflammatory cytokines on functional activity of platelets are demonstrated.
C1 [Suslova, Tatiana E.; Sitozhevskii, Alexei V.; Ogurkova, Oksana N.; Kravchenko, Elena S.; Kologrivova, Irina V.; Anfinogenova, Yana; Karpov, Rostislav S.] Russian Acad Med Sci, Cardiol Res Inst, Fed State Budgetary Sci Inst, Tomsk, Russia.
   [Suslova, Tatiana E.] Natl Res Tomsk State Univ, Ctr High Technol Med, Lab Translat Cellular & Mol Biomed, Tomsk, Russia.
   [Anfinogenova, Yana] Natl Res Tomsk Polytech Univ, Inst Phys & Technol, Tomsk, Russia.
C3 Russian Academy of Sciences; Tomsk National Research Medical Center; E.
   D. Goldberg Research Institute of Pharmacology & Regenerative Medicine;
   Cardiology Research Institute - Tomsk; Russian Academy of Medical
   Sciences; Tomsk State University; Tomsk Polytechnic University
RP Suslova, TE (corresponding author), 111a Kievskaya Street, Tomsk 634012, Russia.
EM tes@cardio-tomsk.ru
RI ; Ogurkova, Oksana/F-8831-2017; Kologrivova, Irina/G-3047-2014; Suslova,
   Tatiana/M-4339-2016; Kravchenko, Elena/L-7723-2016; Karpov,
   Rostislav/F-5406-2014; Anfinogenova, Nina D./E-7458-2014
OI Karpov, Rostislav S./0000-0001-8578-6636; Ogurkova,
   Oksana/0000-0001-8397-0296; Kologrivova, Irina/0000-0003-4537-0008;
   Suslova, Tatiana/0000-0001-9645-6720; Kravchenko,
   Elena/0000-0002-1235-9956; Karpov, Rostislav/0000-0002-7011-4316;
   Anfinogenova, Nina D./0000-0003-1106-0730
FU Seventh Framework Programme [HEALTH-F2-20 10-241558]
FX The work was supported by the Seventh Framework Programme (SICA-HF;
   HEALTH-F2-20 10-241558).
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NR 70
TC 52
Z9 54
U1 0
U2 9
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-042X
J9 FRONT PHYSIOL
JI Front. Physiol.
PD JAN 5
PY 2015
VL 5
AR 501
DI 10.3389/fphys.2014.00501
PG 8
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA AZ4SL
UT WOS:000348213000001
PM 25601838
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Owczarczyk-Saczonek, A
   Kasprowicz-Furmanczyk, M
   Krajewska-Wlodarczyk, M
   Szepietowski, J
AF Owczarczyk-Saczonek, Agnieszka
   Kasprowicz-Furmanczyk, Marta
   Krajewska-Wlodarczyk, Magdalena
   Szepietowski, Jacek
TI Effect of diet and weight loss on the severity of psoriasis
SO POSTEPY HIGIENY I MEDYCYNY DOSWIADCZALNEJ
LA English
DT Review
DE psoriasis; psoriatic arthritis; lifestyle; diet
ID BODY-MASS INDEX; CARDIOVASCULAR RISK-FACTORS; MINIMAL DISEASE-ACTIVITY;
   METABOLIC SYNDROME; PLAQUE PSORIASIS; SELENIUM SUPPLEMENTATION; BIOLOGIC
   THERAPY; ADIPOSE-TISSUE; OBESE-PATIENTS; LIPID PROFILE
AB Psoriasis is one of the most common chronic inflammatory skin diseases, constituting a significant health and socioeconomic problem. Despite numerous therapeutic options, the results of treatment often remain insufficient. This may be due to the lack of compliance with medical prescriptions and patients' limited knowledge of their disease. Psoriatic patient's skin well-being is affected by many factors, including lifestyle. The course of the disease is affected by obesity, improper diet, and stimulants. Often these factors coexist. Excessive weight gain in psoriasis can be caused by a decrease in physical activity, caused by feelings of social stigma, coexistence of psoriatic arthritis, depression, and increased alcohol consumption. Several studies have confirmed that the average fat, protein, and calorie content in the diet of a patient with psoriasis are above the recommended norms. On the other hand, adhering to a low calorie, reducing diet results in a clinically significant improvement in the Psoriasis Area Severity Index (PASI) and patients' quality of life (i.e., reduction of Dermatology Life Quality Index [DLQI]). Weight reduction caused by diet and exercise reduces the severity of skin lesions, even in people who have not achieved improvement after general treatment. Therefore, it is important to educate the patient about the nature of the disease at the very beginning of treatment. Patients with moderate to severe forms of the disease are predisposed to the development of cardiovascular diseases, obesity, diabetes, and anxiety. That is why plaque psoriasis requires a comprehensive treatment and a holistic approach to the patient.
C1 [Owczarczyk-Saczonek, Agnieszka; Kasprowicz-Furmanczyk, Marta] Univ Warmia & Mazury, Dept Dermatol, Sexually Transmitted Dis & Clin Immunol, Olsztyn, Poland.
   [Krajewska-Wlodarczyk, Magdalena] Municipal Polyclin Hosp Olsztyn, Dept Rheumatol, Olsztyn, Poland.
   [Krajewska-Wlodarczyk, Magdalena] Univ Warmia & Mazury, Sch Med, Dept Internal Med, Coll Med, Olsztyn, Poland.
   [Szepietowski, Jacek] Wroclaw Med Univ, Dept Dermatol, Wroclaw, Poland.
C3 University of Warmia & Mazury; University of Warmia & Mazury; Wroclaw
   Medical University
RP Owczarczyk-Saczonek, A; Kasprowicz-Furmanczyk, M (corresponding author), Univ Warmia & Mazury, Dept Dermatol, Sexually Transmitted Dis & Clin Immunol, Olsztyn, Poland.
EM aganek@wp.pl; martak03@wp.pl
RI Krajewska-Włodarczyk, Magdalena/R-6218-2018; Owczarczyk-Saczonek,
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NR 109
TC 2
Z9 2
U1 4
U2 14
PU POLISH ACAD SCIENCES, INST IMMUNOL & EXP THERAPY
PI WROCLAW
PA RUDOLF WEIGL 12, WROCLAW, 53-114, POLAND
SN 0032-5449
EI 1732-2693
J9 POSTEP HIG MED DOSW
JI Postep. Hig. Med. Dosw.
PD JAN 1
PY 2022
VL 76
IS 1
BP 450
EP 460
DI 10.2478/ahem-2022-0039
PG 11
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 7B3XS
UT WOS:000899071000001
OA gold
DA 2025-06-11
ER

PT J
AU Hoang, DV
   Akter, S
   Inoue, Y
   Kuwahara, K
   Fukunaga, A
   Islam, Z
   Nakagawa, T
   Honda, T
   Yamamoto, S
   Okazaki, H
   Miyamoto, T
   Ogasawara, T
   Sasaki, N
   Uehara, A
   Yamamoto, M
   Kochi, T
   Eguchi, M
   Shirasaka, T
   Shimizu, M
   Nagahama, S
   Hori, A
   Imai, T
   Nishihara, A
   Tomita, K
   Nishiura, C
   Konishi, M
   Kabe, I
   Yamamoto, K
   Mizoue, T
   Dohi, S
AF Hoang, Dong V.
   Akter, Shamima
   Inoue, Yosuke
   Kuwahara, Keisuke
   Fukunaga, Ami
   Islam, Zobida
   Nakagawa, Tohru
   Honda, Toru
   Yamamoto, Shuichiro
   Okazaki, Hiroko
   Miyamoto, Toshiaki
   Ogasawara, Takayuki
   Sasaki, Naoko
   Uehara, Akihiko
   Yamamoto, Makoto
   Kochi, Takeshi
   Eguchi, Masafumi
   Shirasaka, Taiki
   Shimizu, Makiko
   Nagahama, Satsue
   Hori, Ai
   Imai, Teppei
   Nishihara, Akiko
   Tomita, Kentaro
   Nishiura, Chihiro
   Konishi, Maki
   Kabe, Isamu
   Yamamoto, Kenya
   Mizoue, Tetsuya
   Dohi, Seitaro
CA Japan Epidemiology Collaboration
TI Metabolic Syndrome and the Increased Risk of Medically Certified
   Long-term Sickness Absence: A Prospective Analysis Among Japanese
   Workers
SO JOURNAL OF EPIDEMIOLOGY
LA English
DT Article
DE Key words; sickness absence; metabolic syndrome; longitudinal study;
   Japan
ID EPIDEMIOLOGY COLLABORATION; CARDIOVASCULAR RISK; ASSOCIATION;
   POPULATION; HEALTH; CANCER; IMPACT; LEAVE
AB Background: Metabolic syndrome (MetS) has been associated with various chronic diseases that may lead to long-term sickness absence (LTSA), but there is lacking information on the direct association between MetS and LTSA. The present study aimed to investigate the all-cause and cause-specific associations between MetS and the risk of medically certified LTSA among Japanese workers. Methods: We recruited 67,403 workers (57,276 men and 10,127 women), aged 20-59 years from 13 companies in Japan during their health check-ups in 2011 (11 companies) and 2014 (2 companies), and we followed them for LTSA events (>= 30 consecutive days) until March 31, 2020. MetS was defined according to the Joint Interim Statement. A Cox proportional hazards regression model was used to estimate hazard ratios (HRs) and its 95% confidence intervals (CIs) for LTSA associated with MetS and its components. Results: During 408,324 person-years of follow-up, 2,915 workers experienced LTSA. The adjusted HR for all-cause LTSA was 1.54 (95% CI, 1.41-1.68) among those with MetS compared to those without MetS. In cause-specific analysis, HRs associated with MetS significantly increased for LTSA due to overall physical disorders (1.76); cardiovascular diseases (3.16); diseases of the musculoskeletal system and connective tissue (2.01); cancers (1.24); obesity-related cancers (1.35); mental, behavioral, and neurodevelopmental disorders (1.28); reaction to severe stress and adjustment disorders (1.46); and external causes (1.46). The number of MetS components were also significantly associated with increased LTSA risk. Conclusion: MetS was associated with an increase in the risk of LTSA due to various diseases among Japanese workers.
C1 [Hoang, Dong V.; Akter, Shamima; Inoue, Yosuke; Kuwahara, Keisuke; Fukunaga, Ami; Islam, Zobida; Konishi, Maki; Mizoue, Tetsuya] Natl Ctr Global Hlth & Med, Dept Epidemiol & Prevent, Tokyo, Japan.
   [Kuwahara, Keisuke] Teikyo Univ, Grad Sch Publ Hlth, Tokyo, Japan.
   [Nakagawa, Tohru; Honda, Toru; Yamamoto, Shuichiro] Hitachi Ltd, Hitachi Hlth Care Ctr, Ibaraki, Japan.
   [Okazaki, Hiroko; Dohi, Seitaro] Mitsui Chem Inc, Tokyo, Japan.
   [Miyamoto, Toshiaki] Nippon Steel Corp Ltd, East Nippon Works, Chiba, Japan.
   [Ogasawara, Takayuki; Sasaki, Naoko] Mitsubishi Fuso Truck & Bus Corp, Kawasaki, Kanagawa, Japan.
   [Uehara, Akihiko] Hidaka Tokushukai Hosp, Hidaka, Hokkaido, Japan.
   [Yamamoto, Makoto] Yamaha Corp, Shizuoka, Japan.
   [Kochi, Takeshi; Eguchi, Masafumi; Shirasaka, Taiki] Furukawa Elect Corp Ltd, Tokyo, Japan.
   [Shimizu, Makiko] JFE Steel Corp, East Japan Works Keihin, Kawasaki, Kanagawa, Japan.
   [Nagahama, Satsue] All Japan Labour Welf Fdn, Tokyo, Japan.
   [Hori, Ai] Univ Tsukuba, Fac Med, Dept Global Publ Hlth, Tsukuba, Ibaraki, Japan.
   [Imai, Teppei] OH Support, Yokohama, Kanagawa, Japan.
   [Nishihara, Akiko] Azbil Corp, Tokyo, Japan.
   [Tomita, Kentaro] Healthplant Co Ltd, Tokyo, Japan.
   [Nishiura, Chihiro] Tokyo Gas Co Ltd, Tokyo, Japan.
   [Kabe, Isamu] Kubota Corp, Tokyo, Japan.
   [Yamamoto, Kenya] Natl Inst Occupat Safety, Div Chem Informat, Kawasaki, Kanagawa, Japan.
C3 Japan Institute for Health Security (JIHS); National Center for Global
   Health & Medicine - Japan; Teikyo University; Hitachi Limited; Mitsui
   Chemicals; Nippon Steel & Sumitomo Metal Corporation; Daimler AG;
   Yamaha; Furukawa Electric; JFE Holdings, Inc.; JFE Steel; University of
   Tsukuba; Tokyo Gas Co., Ltd.; Kubota Corporation
RP Hoang, DV (corresponding author), Natl Ctr Global Hlth & Med, Ctr Clin Sci, Dept Epidemiol & Prevent, 1-21-1 Toyama,Shinju Ku, Tokyo 1628655, Japan.
EM vhoang@hosp.ncgm.go.jp
RI Sasaki, Naoko/JRW-4134-2023; Yamamoto, Kouichi/AAN-1586-2021; Nishiura,
   Chihiro/C-4132-2017; Fukunaga, Ami/LFT-3303-2024; Hori, Ai/G-5277-2019;
   Akter Swapna, Shamima/AAA-5921-2022
OI Islam, Zobida/0000-0002-6785-1753; Inoue, Yosuke/0000-0002-7690-3447;
   Fukunaga, Ami/0000-0002-8705-0056
FU Industrial Health Foundation [140202-01, 150903- 01, 170301-01]; Japan
   Society for the Promotion of Science [JP16H05251]; National Center for
   Global Health and Medicine [28-Shi-1206]
FX This study was financially supported by the Industrial Health Foundation
   (http:// www.ihf.or.jp/) (140202-01, 150903- 01, and 170301-01) , the
   Japan Society for the Promotion of Science (KAKENHI JP16H05251) , and
   the National Center for Global Health and Medicine (28-Shi-1206) .
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NR 45
TC 3
Z9 3
U1 0
U2 3
PU JAPAN EPIDEMIOLOGICAL ASSOC
PI TOKYO
PA HONGO MT BLDG, 4 FL, 7-2-2, HONGO, BUNKYO-KU, TOKYO, JAPAN
SN 0917-5040
J9 J EPIDEMIOL
JI J. Epidemiol.
PD JUN
PY 2023
VL 33
IS 6
BP 311
EP 320
DI 10.2188/jea.JE20210185
PG 10
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA H2AA2
UT WOS:000994031600001
PM 34690243
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Adeoye, AM
   Akintunde, AA
   Akinyemi, J
   Fakunle, AG
   Sarfo, FS
   Akpalu, A
   Wahab, K
   Obiako, R
   Komolafe, M
   Owolabi, L
   Osaigbovo, GO
   Akpa, O
   Arulogun, O
   Okekunle, AP
   Ogah, OS
   Jenkins, C
   Ogbole, G
   Tiwari, HK
   Asowata, OJ
   Ibinaiye, P
   Appiah, L
   Agunloye, AM
   Yaria, J
   Calys-Tagoe, B
   Agbogu-Ike, OU
   Adeniyi, S
   Adebayo, P
   Balogun, O
   Aderonmu, O
   Adeegbe, OT
   Adebayo, O
   Akinyemi, R
   Ovbiagele, B
   Owolabi, M
   Siren, SIREN
AF Adeoye, Abiodun M.
   Akintunde, Adeseye A.
   Akinyemi, Joshua
   Fakunle, Adekunle G.
   Sarfo, Fred S.
   Akpalu, Albert
   Wahab, Kolawole
   Obiako, Reginald
   Komolafe, Morenikeji
   Owolabi, Lukman
   Osaigbovo, Godwin O.
   Akpa, Onoja
   Arulogun, Oyedunni
   Okekunle, Akinkunmi P.
   Ogah, Okechukwu S.
   Jenkins, Carolyn
   Ogbole, Godwin
   Tiwari, Hemant K.
   Asowata, Osahon J.
   Ibinaiye, Philip
   Appiah, Lambert
   Agunloye, Atinuke M.
   Yaria, Joseph
   Calys-Tagoe, Benedict
   Agbogu-Ike, Obiageli U.
   Adeniyi, Sunday
   Adebayo, Philip
   Balogun, Olayemi
   Aderonmu, Olajumoke
   Adeegbe, Oluwayemisi T.
   Adebayo, Oladimeji
   Akinyemi, Rufus
   Ovbiagele, Bruce
   Owolabi, Mayowa
   SIREN, S. I. R. E. N.
TI Determinants of metabolic syndrome and its prognostic implications among
   stroke patients in Africa: Findings from the Stroke Investigative
   Research and Educational Network (SIREN) study
SO JOURNAL OF THE NEUROLOGICAL SCIENCES
LA English
DT Article
DE Metabolic syndrome; Stroke; Prognostic implications; Stroke
   Investigative Research and Educational; Network (SIREN); Africans
ID SEX-DIFFERENCES; GENDER-DIFFERENCES; ISCHEMIC-STROKE; RISK-FACTORS;
   CARDIOVASCULAR MORTALITY; CLASSIFICATION; EPIDEMIOLOGY; MANAGEMENT;
   SUBTYPES; DISEASE
AB Background: The prognostic implications of metabolic syndrome (METS) among African stroke patients are poorly understood. This study aimed to investigate the determinants of METS and its prognostic implications among Africans with newly diagnosed stroke in the SIREN study. Methods: We included stroke cases (adults aged > 18 years with CT/MRI confirmed stroke). The validated tools comprehensively evaluated vascular, lifestyle, and psychosocial factors. We used logistic regression to estimate adjusted odds ratios (OR) with 95% CIs for the association between METS and risk factors. We also computed the prediction power of the domain of covariates in a sequential manner using the area under the receiver operating curve (ROC) curve. Results: Among 3998 stroke subjects enrolled in the study, 76.8% had METS by at least one of the clinical def-initions. Factors associated with METS were age > 50 years (OR-1.46, CI-1.19-1.80), male gender (OR 4.06, CI -3.28-5.03), income > 100USD (OR1.42, CI-1.17-1.71), stress (OR1.46, CI-1.14-1.87), family history of diabetes mellitus (OR1.38, CI-1.06-1.78), and cardiac disease (OR1.42, CI-1.18-1.65). Stroke severity was higher among those with METS (SLS = 5.8 +/- 4.3) compared with those without METS (6.2 +/- 4.5) at p = 0.037. METS was associated with higher odds (aOR 1.31, CI-1.08-1.58) of one-month fatality after adjusting for stroke severity, age > 50 years, and average monthly income > 100USD. Conclusion: METS is very common among African stroke patients and is associated with stroke severity and worse one-month fatality. Lifestyle interventions may prevent METS and attenuate its impact on stroke occurrence and outcomes.
C1 [Adeoye, Abiodun M.; Agunloye, Atinuke M.; Adeegbe, Oluwayemisi T.; Adebayo, Oladimeji; Owolabi, Mayowa] Univ Ibadan, Dept Med, Ibadan, Nigeria.
   [Adeoye, Abiodun M.; Ogah, Okechukwu S.; Agunloye, Atinuke M.; Yaria, Joseph; Aderonmu, Olajumoke] Univ Coll Hosp, Ibadan, Nigeria.
   [Akintunde, Adeseye A.; Adebayo, Philip] Ladoke Akintola Univ Technol LAUTECH, Ogbomosho, Oyo State, Nigeria.
   [Akintunde, Adeseye A.; Ibinaiye, Philip] LAUTECH teaching Hosp, Ogbomosho, Oyo, Nigeria.
   [Akinyemi, Joshua; Akpa, Onoja; Okekunle, Akinkunmi P.; Asowata, Osahon J.] Univ Ibadan, Coll Med, Dept Epidemiol & Med Stat, Ibadan, Nigeria.
   [Fakunle, Adekunle G.] Osun State Univ, Dept Publ Hlth, Osogbo, Osun State, Nigeria.
   [Sarfo, Fred S.; Appiah, Lambert] Kwame Nkrumah Univ Sci & Technol, Dept Med, Kumasi, Ghana.
   [Akpalu, Albert] Univ Ghana Med Sch, Dept Med, Accra, Ghana.
   [Wahab, Kolawole; Adeniyi, Sunday] Univ Ilorin, Teaching Hosp, Dept Med, Ilorin, Nigeria.
   [Obiako, Reginald; Ibinaiye, Philip; Agbogu-Ike, Obiageli U.; Balogun, Olayemi] Ahmadu Bello Univ, Dept Med, Ibadan, Nigeria.
   [Komolafe, Morenikeji] Obafemi Awolowo Univ, Teaching Hosp, Dept Med, Ife, Nigeria.
   [Owolabi, Lukman] Aminu Kano Teaching Hosp, Dept Med, Kano, Nigeria.
   [Osaigbovo, Godwin O.] Jos Univ, Teaching Hosp Jos, Jos, Nigeria.
   [Arulogun, Oyedunni; Akinyemi, Rufus; Owolabi, Mayowa] Univ Ibadan, Coll Med, Ctr Genom & Precis Med, Ibadan, Nigeria.
   [Jenkins, Carolyn] Med Univ South Carolina, Charleston, SC USA.
   [Ogbole, Godwin] Univ Ibadan, Dept Radiol, Ibadan, Nigeria.
   [Tiwari, Hemant K.] Univ Alabama Birmingham, Birmingham, AL USA.
   [Calys-Tagoe, Benedict] Univ Ghana, Med Sch, Dept Community Hlth, Accra, Ghana.
   [Akinyemi, Rufus] Fed Med Ctr, Abeokuta, Nigeria.
   [Ovbiagele, Bruce] Univ Calif San Francisco, Weill Inst Neurosci, Sch Med, Francisco, IN USA.
C3 University of Ibadan; University of Ibadan; University College Hospital,
   Ibadan; University of Ibadan; Kwame Nkrumah University Science &
   Technology; University of Ghana; University of Ilorin; Ahmadu Bello
   University; Obafemi Awolowo University; University of Ibadan; Medical
   University of South Carolina; University of Ibadan; University of
   Alabama System; University of Alabama Birmingham; University of Ghana
RP Owolabi, M (corresponding author), Univ Ibadan, Dept Med, Ibadan, Nigeria.
EM jenkins@musc.edu; htiwari@uab.edu; bruce.ovbiagele@va.gov;
   mayowaowolabi@yahoo.com
RI ADENIYI, SUNDAY/Q-9150-2019; Appiah, Lambert/HJP-4452-2023; Adebayo,
   Philip/ABE-1191-2020; Asowata, Osahon/LKM-9679-2024; Okekunle,
   Akinkunmi/AAC-9804-2020; Ibinaiye, Philip/AAR-6762-2020; Ghanbari,
   Mohsen/AAH-1340-2020; Owolabi, Lukman/AAI-5084-2021; Akinyemi,
   Rufus/X-2370-2019; Arulogun, Oyedunnii/AAL-2714-2021; Akintunde,
   Adeseye/AAA-8679-2020; Adebayo, Oladimeji/Y-5260-2019; Wahab, Kolawole
   Wasiu/F-1206-2010
OI Ibinaiye, Philip/0000-0002-8602-4251; Ogah,
   Okechukwu/0000-0002-2093-7787; Akinyemi, Joshua/0000-0002-0675-2110;
   Okekunle, Akinkunmi/0000-0003-4825-4934; Wahab, Kolawole
   Wasiu/0000-0002-2914-1953; Ogbole, Godwin/0000-0003-0431-7198; Fakunle,
   Adekunle/0000-0001-8391-9394
FU National Institutes of Health [U54HG007479, R01NS115944-01]; SIBS Gen
   Gen [1R01NS114045-01]; African Neurobiobank for Precision Stroke
   Medicine ELSI project [3U24HG009780-03S5]; ARISES [1R13NS115395-01A1];
   H3Africa CVD Supplement [D43TW012030]; CaNVAS; Sub-Saharan Africa
   Conference on Stroke (SSACS) Conference; Training Africans to Lead and
   Execute Neurological Trials & Studies (TALENTS);  [R01NS107900]; 
   [R01NS107900-02S1];  [U01HG010273]
FX The study and investigators were supported by the National Institutes of
   Health grants SIREN (U54HG007479) , SIBS Genomics (R01NS107900) ,
   African Neurobiobank for Precision Stroke Medicine ELSI project
   (U01HG010273) , SIBS Gen Gen (R01NS107900-02S1) , ARISES
   (R01NS115944-01) , H3Africa CVD Supplement (3U24HG009780-03S5) , and
   CaNVAS (1R01NS114045-01) , Sub-Saharan Africa Conference on Stroke
   (SSACS) Conference 1R13NS115395-01A1 and Training Africans to Lead and
   Execute Neurological Trials & Studies (TALENTS) D43TW012030.
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NR 55
TC 2
Z9 2
U1 0
U2 3
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0022-510X
EI 1878-5883
J9 J NEUROL SCI
JI J. Neurol. Sci.
PD OCT 15
PY 2022
VL 441
AR 120360
DI 10.1016/j.jns.2022.120360
EA AUG 2022
PG 10
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 4X6YS
UT WOS:000860986000005
PM 35985161
DA 2025-06-11
ER

PT J
AU Angulo-Bejarano, PI
   Gómez-García, MD
   Valverde, ME
   Paredes-López, O
AF Isabel Angulo-Bejarano, Paola
   del Rocio Gomez-Garcia, Maria
   Elena Valverde, Maria
   Paredes-Lopez, Octavio
TI Nopal (Opuntia spp.) and its Effects on Metabolic Syndrome: New
   Insights for the Use of a Millenary Plant
SO CURRENT PHARMACEUTICAL DESIGN
LA English
DT Review
DE Diabetes; hypercholesterolemia; metabolic syndrome; nopal; obesity;
   Cactaceae family
ID ATTENUATES HEPATIC STEATOSIS; FICUS-INDICA CLADODES; BLOOD-GLUCOSE; SEED
   OIL; STREPTACANTHA LEMAIRE; BIOLOGICAL PARAMETERS; CHEMICAL-COMPOSITION;
   CHOLESTEROL LEVELS; SUPPLEMENTED DIET; OXIDATIVE STRESS
AB Background: Nopal (Opuntia spp.) is by excellence the most utilized cactus in human and animal nutrition. It is also a very noble plant; its main physicochemical, nutritional and nutraceutical characteristics allow the use of nopal in diverse food applications. Special focus has been given over the past decades in the use of Opuntia for the treatment of metabolic syndrome (MetS), which is predominantly related to Diabetes Mellitus. In this sense, the prevalence of MetS is increasing at a worldwide level. This in turn has led to a notorious demand for natural and nutraceutical food sources.
   Methods: The objective of this work was to summarize the main contributions in the field of Opuntia spp. research highlighting the potential use of nopal fruits or cladodes in MetS treatment, providing the reader with historical and novel information in this field. Nevertheless, the present work is not a meta-analysis. We included mainly information from recognized scientific databases, such as PubMed, Scopus, Web of Science and Google Scholar. No homeopathic based studies were included since they lack scientific validation. To the best of our knowledge, this is the first review that fairly categorizes the majority of the information in this field into subsections, which can be of interest for the reader, such as the effect of nopal against cardiovascular disease, type 2 diabetes mellitus, and obesity among others.
   Conclusion: Nopal constitutes one of the most studied members of the Cactaceae family; its potential effects on human health have been described since ancient times, mostly through traditional medicine. The present work highlights the importance of this plant in the treatment of MetS related maladies and points out the importance of elucidating new compounds and their validation for the interactions of nutraceutical compounds which could be related to MetS.
C1 [Isabel Angulo-Bejarano, Paola] Tecnol Monterrey, Sch Engn & Sci, Ctr Bioengn, Campus Queretaro, Queretaro, Qro, Mexico.
   [del Rocio Gomez-Garcia, Maria; Elena Valverde, Maria; Paredes-Lopez, Octavio] IPN, Ctr Invest & Estudios Avanzados, Campus Irapuato,Km 9-6 Libramiento Norte, Guanajuato 36821, Mexico.
C3 Tecnologico de Monterrey; CINVESTAV - Centro de Investigacion y de
   Estudios Avanzados del Instituto Politecnico Nacional; Instituto
   Politecnico Nacional - Mexico
RP Paredes-López, O (corresponding author), IPN, Ctr Invest & Estudios Avanzados, Campus Irapuato,Km 9-6 Libramiento Norte, Guanajuato 36821, Mexico.
EM octavio.paredes@cinvestav.mx
RI Angulo-Bejarano, Paola Isabel/AAG-3160-2019; NACIONAL, CENTRO DE
   INVESTIGACIÓN Y DE ESTUDIOS AVANZADOS DEL INSTITUTO/AEZ-9390-2022
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NR 124
TC 21
Z9 21
U1 0
U2 22
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1381-6128
EI 1873-4286
J9 CURR PHARM DESIGN
JI Curr. Pharm. Design
PY 2019
VL 25
IS 32
BP 3457
EP 3477
DI 10.2174/1381612825666191010171819
PG 21
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA JN6CH
UT WOS:000496983500004
PM 31604414
DA 2025-06-11
ER

PT J
AU Chanakya, K
   Shobha, V
   Chandrashekara, S
   Kumar, S
   Haridas, V
   Rao, V
   Jois, R
   Daware, M
   Singh, Y
   Singhai, S
   Dharmanad, BG
   Chebbi, P
   Ramaswamy, S
   Kamath, A
   Karjiigi, U
   Jain, VK
   Dharmaplaiah, C
   Prasad, S
   Srinivas, C
   Janardana, R
   Pinto, B
   Nazir, B
   Harshini, AS
   Mahendranath
AF Chanakya, K.
   Shobha, Vineeta
   Chandrashekara, S.
   Kumar, Sharath
   Haridas, Vikram
   Rao, Vijay
   Jois, Ramesh
   Daware, Manisha
   Singh, Yogesh
   Singhai, Shweta
   Dharmanad, Balebail G.
   Chebbi, Pramod
   Ramaswamy, Subramanian
   Kamath, Ashwini
   Karjiigi, Uma
   Jain, VikramRaj K.
   Dharmaplaiah, Chethana
   Prasad, Shiva
   Srinivas, C.
   Janardana, Ramya
   Pinto, Benzeeta
   Nazir, Beenish
   Harshini, A. S.
   Mahendranath
TI Comorbidity burden in psoriatic arthritis and its impact on disease
   measures
SO INDIAN JOURNAL OF RHEUMATOLOGY
LA English
DT Article
DE Diabetes mellitus; dyslipidemia; hypertension; metabolic syndrome;
   obesity; psoriatic arthritis comorbidity index
ID BODY-MASS INDEX; QUALITY-OF-LIFE; RHEUMATOID-ARTHRITIS; MANAGING
   COMORBIDITIES; CARDIOVASCULAR-DISEASE; OBESITY; MORTALITY; RISK;
   EPIDEMIOLOGY; PREVALENCE
AB Introduction: Comorbidities frequently accompany psoriasis and psoriatic arthritis (PsA) and add to the disease burden. We aimed to identify the comorbidity burden in patients with PsA and evaluate its impact on the disease activity measures in our geographic region. Methods: This was a multicenter, cross-sectional study involving consecutive PsA patients from 17 rheumatology centers. Their disease variables and comorbidities were recorded. Results: In 549 enrolled patients, the mean age was 39.2 (14.9) years, with male predominance (6:5). The mean duration of PsA was 63.1 (76.3) months and 232 (42.3%) patients had one or more comorbidities. Dyslipidemia was the most prevalent comorbidity, followed by hypertension (HTN) (19.8%) and diabetes (16.6%). About 39% of patients were overweight and 18% were obese. Smoking, ischemic heart disease, hypothyroidism, osteoarthritis, depression, anxiety, and fractures were seen in <5% of the cohort. Increasing age, longer duration of psoriasis, a family history of cardiovascular disease (CVD) or stroke, smoking, alcohol consumption, and higher waist circumference were associated with the presence of one or more comorbidities. Overall, 104 (18.9%) patients needed hospitalization for various comorbidities. Infections accounted for 59 (10.8%), of which skin (23) was the most common site, followed by urinary tract (6) and lung (4).Conclusions: More than 40% of PsA patients have comorbidities. Dyslipidemia, HTN, diabetes, and obesity were most prevalent, putting these patients at risk for CVDs. Active screening for these comorbidities is crucial for providing comprehensive care to these patients.
C1 [Chanakya, K.; Shobha, Vineeta; Janardana, Ramya; Pinto, Benzeeta] St Johns Med Coll Hosp, Dept Clin Immunol, Bangalore, Karnataka, India.
   [Chanakya, K.; Shobha, Vineeta; Janardana, Ramya; Pinto, Benzeeta] St Johns Med Coll Hosp, Dept Rheumatol, Bangalore, Karnataka, India.
   [Chandrashekara, S.; Nazir, Beenish] Chanre Rheumatol & Immunol Res Ctr, Bangalore, Karnataka, India.
   [Kumar, Sharath] Columbia Asia Hosp, Dept Rheumatol, Bangalore, Karnataka, India.
   [Rao, Vijay] Manipal Hosp, Dept Rheumatol, Bangalore, Karnataka, India.
   [Jois, Ramesh; Dharmanad, Balebail G.] Vikram Hosp, Dept Rheumatol, Bangalore, Karnataka, India.
   [Daware, Manisha] Narayana Hlth City, Dept Clin Immunol & Rheumatol, Bangalore, Karnataka, India.
   [Singhai, Shweta] Sakra Hosp, Dept Rheumatol, Bengaluru, Karnataka, India.
   [Karjiigi, Uma] Apollo Hosp, Dept Rheumatol, Bengaluru, Karnataka, India.
   [Jain, VikramRaj K.] Mahaveer Jain Hosp, Dept Clin Immunol, Bengaluru, Karnataka, India.
   [Jain, VikramRaj K.] Mahaveer Jain Hosp, Dept Rheumatol, Bengaluru, Karnataka, India.
   [Dharmaplaiah, Chethana] Aster CMI Hosp, Dept Rheumatol, Bengaluru, Karnataka, India.
   [Srinivas, C.] Fortis Hosp, Dept Rheumatol, Bengaluru, Karnataka, India.
   [Harshini, A. S.] Sparsh Hosp, Dept Rheumatol, Bengaluru, Karnataka, India.
   [Mahendranath] Samarpan Hlth Ctr, Bengaluru, Karnataka, India.
   [Haridas, Vikram] Arthrit Specialty Clin, Hubli, Karnataka, India.
   [Ramaswamy, Subramanian] JSS Med Coll, Dept Rheumatol & Immunol, Mysore, Karnataka, India.
   [Prasad, Shiva] Apollo BGS Hosp, Mysore, Karnataka, India.
   [Chebbi, Pramod] SDM Med Coll, Dept Rheumatol & Clin Immunol, Dharwad, Karnataka, India.
   [Kamath, Ashwini] Yenepoya Specialty Hosp, Dept Rheumatol, Mangalore, Karnataka, India.
   [Shobha, Vineeta] St Johns Med Coll Hosp, Dept Clin Immunol & Rheumatol, Sarjapur Rd, Bengaluru 560034, Karnataka, India.
C3 St. John's National Academy of Health Sciences; St. John's Medical
   College; St. John's National Academy of Health Sciences; St. John's
   Medical College; JSS Academy of Higher Education & Research; JSS Medical
   College, Mysuru; Yenepoya (Deemed to be University); St. John's National
   Academy of Health Sciences; St. John's Medical College
RP Shobha, V (corresponding author), St Johns Med Coll Hosp, Dept Clin Immunol & Rheumatol, Sarjapur Rd, Bengaluru 560034, Karnataka, India.
EM vineeta.s@stjohns.in
RI JAIN, VIKRAMRAJ/NFT-3290-2025; Chebbi, Pramod/AAY-6728-2021;
   Subramanian, Ramaswamy/Q-8671-2019
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NR 38
TC 2
Z9 2
U1 1
U2 2
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, Maharashtra, INDIA
SN 0973-3698
EI 0973-3701
J9 INDIAN J RHEUMATOL
JI Indian J. Rheumatol.
PD JUL-SEP
PY 2023
VL 18
IS 3
BP 185
EP 191
DI 10.4103/injr.injr_29_22
PG 7
WC Rheumatology
WE Emerging Sources Citation Index (ESCI)
SC Rheumatology
GA S1KY2
UT WOS:001068838800002
OA gold
DA 2025-06-11
ER

PT J
AU Kremers, SHM
   Beulens, JWJ
   Strikwerda, M
   Remmelzwaal, S
   Schoonmade, LJ
   van der Beek, AJ
   Elders, PJM
   Rutters, F
AF Kremers, Sanne H. M.
   Beulens, Joline W. J.
   Strikwerda, Marije
   Remmelzwaal, Sharon
   Schoonmade, Linda J.
   van der Beek, Allard J.
   Elders, Petra J. M.
   Rutters, Femke
TI The Association of Burnout and Vital Exhaustion With (Measures of) the
   Metabolic Syndrome: A Systematic Review and Meta-Analysis
SO HEALTH PSYCHOLOGY
LA English
DT Article; Early Access
DE burnout; vital exhaustion; metabolic syndrome; systematic review;
   meta-analysis
ID PSYCHOSOCIAL RISK-FACTORS; CARDIOVASCULAR-DISEASE; ATHEROSCLEROSIS RISK;
   PHYSIOLOGICAL REACTIONS; SCHOOL BURNOUT; BLOOD-PRESSURE; HEART-DISEASE;
   WORK STRESS; LIFE-STYLE; BIOMARKERS
AB Objective: This systematic review and meta-analysis aims to investigate the association of burnout and vital exhaustion (VE) symptoms with (measures of) the metabolic syndrome (MetS). Method: PubMed, Embase, and PsycINFO were systematically searched until April 26, 2024. Studies investigating adult populations, burnout, or VE as exposures and (measures of) MetS as outcomes were included. Data extraction and quality assessment were performed independently by two observers. If at least three independent effect measures (in at least two studies) were available per association, meta-analyses were performed using random-effects models. Results: We included 101 studies (71% cross-sectional, 11% case-control, 13% prospective, 5% alternative) comprising 22 strong, 55 moderate, and 24 weak quality studies. Meta-analyses showed relevant but statistically nonsignificant associations of burnout and VE symptoms with higher incident (odds ratio [OR] = 1.53 [0.82, 2.87], I-2 = 0%) and prevalent MetS (OR = 1.28 [0.99, 1.64], I-2 = 85%), incident obesity (OR = 1.88 [0.81, 4.36], I-2 = 0%), waist-to-hip ratio (standardized mean difference = 0.62 [-0.65, 1.90], I-2 = 95%), prevalent high waist circumference (OR = 1.14 [0.80, 1.62], I-2 = 28%), high triglycerides (OR = 1.49 [0.82, 2.71], I-2 = 40%), and a significantly higher prevalent hypertension (OR = 1.63 [1.44, 1.84], I-2 = 51%). We found no clinically relevant associations with remaining MetS measures. Conclusions: Burnout and VE symptoms might be associated with a higher odds of prevalent and incident MetS, however, not statistically significant. These results should be interpreted with caution due to the cross-sectional design of most studies, use of unadjusted baseline data, and substantial heterogeneity in some analyses.
C1 [Kremers, Sanne H. M.; Beulens, Joline W. J.; Strikwerda, Marije; Remmelzwaal, Sharon; Rutters, Femke] Vrije Univ Amsterdam, Amsterdam UMC Locat, Dept Epidemiol & Data Sci, Meibergdreef 9, NL-1105 Amsterdam, Netherlands.
   [Kremers, Sanne H. M.; Beulens, Joline W. J.; Remmelzwaal, Sharon; van der Beek, Allard J.; Elders, Petra J. M.; Rutters, Femke] Amsterdam Publ Hlth Res Inst, Hlth Behav & Chron Dis, Amsterdam, Netherlands.
   [Beulens, Joline W. J.] Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands.
   [Remmelzwaal, Sharon; Elders, Petra J. M.] Vrije Univ Amsterdam, Amsterdam UMC Locat, Dept Gen Pract, Amsterdam, Netherlands.
   [Schoonmade, Linda J.] Vrije Univ Amsterdam, Univ Lib, Amsterdam, Netherlands.
   [van der Beek, Allard J.] Locat Vrije Univ Amsterdam, Dept Publ & Occupat Hlth, Amsterdam UMC, Amsterdam, Netherlands.
C3 Vrije Universiteit Amsterdam; Vrije Universiteit Amsterdam; Utrecht
   University; Utrecht University Medical Center; Vrije Universiteit
   Amsterdam; Vrije Universiteit Amsterdam; University of Amsterdam
RP Kremers, SHM (corresponding author), Vrije Univ Amsterdam, Amsterdam UMC Locat, Dept Epidemiol & Data Sci, Meibergdreef 9, NL-1105 Amsterdam, Netherlands.
EM s.kremers@amsterdamumc.nl
RI Schoonmade, Linda/P-4413-2019
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NR 130
TC 0
Z9 0
U1 4
U2 4
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 0278-6133
EI 1930-7810
J9 HEALTH PSYCHOL
JI Health Psychol.
PD 2025 APR 10
PY 2025
DI 10.1037/hea0001498
EA APR 2025
PG 15
WC Psychology, Clinical; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology
GA 1HW9Q
UT WOS:001465413800001
PM 40208748
DA 2025-06-11
ER

PT J
AU Tsai, HJ
   Tsou, MT
AF Tsai, Huel-Ju
   Tsou, Meng-Ting
TI Age, Sex, and Profession Difference Among Health Care Workers With
   Burnout and Metabolic Syndrome in Taiwan Tertiary Hospital-A
   Cross-Section Study
SO FRONTIERS IN MEDICINE
LA English
DT Article
DE health care workers; burnout; metabolic syndrome; Taiwan; sex
ID C-REACTIVE PROTEIN; SHIFT-WORK; CARDIOVASCULAR RISK; SLEEP DURATION;
   JOB; MEN; ASSOCIATION; POPULATION; STRESS; GENDER
AB BackgroundThis cross-sectional study aimed to analyze the association between burnout, work-related factors and metabolic syndrome (MetS) among various health-care workers (HCWs) at a tertiary hospital in Taiwan. MethodsRelevant demographic data were obtained through written questionnaires. Information about psychosocial and work conditions, including assigned department, working hours, shifts, and sleep condition, was obtained. Burnout was evaluated according to the Chinese version of Maslach Burnout Inventory-Health Services Survey. MetS was analyzed according to the criteria of the National Cholesterol Education Program of Taiwan-Treatment Panel for Adults III. ResultsA total of 1,055 non-doctor/nurse and 2,078 doctor/nurse staff with a median age of 45.2 and 36.1 years participated in this study. The incidence of burnout was nearly 6.42 and 6.68% and that of MetS was 31.4 and 13.5% in non-doctor/nurse and doctor/nurse staff, respectively. The results showed that burnout induced a higher Odds ratio (OR) of MetS in the doctor/nurse group (OR = 1.96, p = 0.01). Other factors, such as night shift and seniority (>10 years), led to a higher OR of MetS, but a decreased risk was observed based on seniority (2-4 years). Further, young female participants and young doctors/nurses with burnout had a higher OR of MetS compare to other groups (OR = 2.43 and 2.32, p < 0.05). ConclusionThe study results suggested positive relationship between burnout and MetS in young female staffs and young doctors/nurses. For doctor/nurse staff with higher seniority or more night shifts, strategies are needed to prevent burnout and MetS.
C1 [Tsai, Huel-Ju] MacKay Mem Hosp, Dept Hlth Evaluat Ctr, Taipei, Taiwan.
   [Tsai, Huel-Ju; Tsou, Meng-Ting] MacKay Mem Hosp, Dept Family Med, Taipei, Taiwan.
   [Tsou, Meng-Ting] MacKay Mem Hosp, Dept Occupat Med, Taipei, Taiwan.
   [Tsou, Meng-Ting] Dept MacKay Jr Coll Med Nursing & Management, New Taipei, Taiwan.
C3 Mackay Memorial Hospital; Mackay Memorial Hospital; Mackay Memorial
   Hospital
RP Tsou, MT (corresponding author), MacKay Mem Hosp, Dept Family Med, Taipei, Taiwan.; Tsou, MT (corresponding author), MacKay Mem Hosp, Dept Occupat Med, Taipei, Taiwan.; Tsou, MT (corresponding author), Dept MacKay Jr Coll Med Nursing & Management, New Taipei, Taiwan.
EM mttsou@gmail.com
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NR 54
TC 10
Z9 10
U1 4
U2 20
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 2296-858X
J9 FRONT MED-LAUSANNE
JI Front. Med.
PD APR 14
PY 2022
VL 9
AR 854403
DI 10.3389/fmed.2022.854403
PG 10
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 1B5KZ
UT WOS:000792476900001
PM 35492349
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Galvis-Pérez, Y
   Marín-Echeverri, C
   Escobar, CPF
   Aristizábal, JC
   Fernández, ML
   Barona-Acevedo, J
AF Galvis-Perez, Yeisson
   Marin-Echeverri, Catalina
   Franco Escobar, Claudia Patricia
   Aristizabal, Juan C.
   Fernandez, Maria-Luz
   Barona-Acevedo, Jacqueline
TI Comparative Evaluation of the Effects of Consumption of Colombian Agraz
   (Vaccinium meridionale Swartz) on Insulin Resistance, Antioxidant
   Capacity, and Markers of Oxidation and Inflammation, Between Men and
   Women with Metabolic Syndrome
SO BIORESEARCH OPEN ACCESS
LA English
DT Article
DE agraz; antioxidants; inflammation; insulin resistance; metabolic
   syndrome; oxidative stress
ID SEX-DIFFERENCES; GENDER-DIFFERENCES; RISK-FACTORS; POLYPHENOLS; BLOOD;
   OBESE; PREVALENCE; MANAGEMENT; COMPONENTS; ESTROGEN
AB The metabolic syndrome (MS) is a constellation of related factors that increases the risk of developing cardiovascular diseases. Vaccinium meridionale Swartz contains polyphenols that could modulate some components of MS. Epidemiological and intervention studies have shown differences between men and women in MS components and antioxidant capacity. The objective of this study is to compare between men and women with MS the effects of agraz consumption on insulin resistance, antioxidant capacity, and markers of oxidation and inflammation. Men and women diagnosed with MS according to the Adult Treatment Panel III criteria were recruited in a double-blind, crossover study of 12 weeks. Participants were assigned to consume agraz nectar or placebo over 4 weeks. After 4 weeks of washout, they were switched to the alternative treatment. At the end of each period, the components of the MS, insulin resistance, antioxidant capacity, and some oxidative (oxidized low-density lipoprotein [oxLDL]; thiobarbituric acid reactive substances) and inflammatory (high-sensitive C-reactive protein [hs-CRP]) markers were evaluated. After consuming agraz, there was a tendency to increase the levels of antioxidants and to reduce the levels of hs-CRP in both genders. In addition, women who increased their serum phenols after consuming agraz had a significant reduction in insulin resistance, which was different from the results in men. Regarding men, those who increased their serum antioxidant capacity after consuming agraz had a better effect on the reduction of oxLDL levels that was significant compared to women. There are important differences between genders in the effects of agraz consumption in adults with MS.
C1 [Galvis-Perez, Yeisson; Marin-Echeverri, Catalina; Franco Escobar, Claudia Patricia; Barona-Acevedo, Jacqueline] Univ Antioquia UdeA, Sch Microbiol, Res Grp Toxinol Therapeut & Food Alternat, Calle 70 52-21, Medellin 050010, Colombia.
   [Aristizabal, Juan C.] Univ Antioquia UdeA, Sch Nutr & Dietet, Res Grp Physiol & Biochem PHYSIS, Medellin, Colombia.
   [Fernandez, Maria-Luz] Univ Connecticut, Dept Nutr Sci, Storrs, CT USA.
C3 Universidad de Antioquia; Universidad de Antioquia; University of
   Connecticut
RP Barona-Acevedo, J (corresponding author), Univ Antioquia UdeA, Sch Microbiol, Res Grp Toxinol Therapeut & Food Alternat, Calle 70 52-21, Medellin 050010, Colombia.
EM maria.barona@udea.edu.co
RI Rivera, Juan/B-6591-2014
OI Barona Acevedo, Maria Jacqueline/0000-0002-0592-9324; Marin Echeverri,
   Catalina/0000-0002-4267-5677
FU Committee for the Development of Research-CODI-University of Antioquia,
   in the Programmatic Call of Health Sciences, 2016 [2015-7804];
   Colciencias [657-2014]
FX This study was funded by the Committee for the Development of
   Research-CODI-University of Antioquia, in the Programmatic Call of
   Health Sciences, 2016. Act No. 2015-7804. Part of this study was funded
   by Colciencias - Contract No. 657-2014.
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NR 62
TC 4
Z9 5
U1 0
U2 4
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 2164-7860
J9 BIORESEARCH OPEN ACC
JI BioResearch Open Access
PD NOV 1
PY 2020
VL 9
IS 1
BP 247
EP 254
DI 10.1089/biores.2020.0053
PG 8
WC Biochemistry & Molecular Biology
WE Emerging Sources Citation Index (ESCI)
SC Biochemistry & Molecular Biology
GA OY4HG
UT WOS:000594208600001
PM 33269114
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Buinitskaya, Y
   Gurinovich, R
   Wlodaver, CG
   Kastsiuchenka, S
AF Buinitskaya, Yuliya
   Gurinovich, Roman
   Wlodaver, Clifford G.
   Kastsiuchenka, Siarhei
TI Centrality of G6PD in COVID-19: The Biochemical Rationale and Clinical
   Implications
SO FRONTIERS IN MEDICINE
LA English
DT Article
DE COVID-19; glucose-6-phosphate dehydrogenase (G6PD); reactive oxygen
   species; nitric oxide - NO; glutathione; aldosterone (Ald); Metabolic
   syndrome
ID GLUCOSE INHIBITS GLUCOSE-6-PHOSPHATE-DEHYDROGENASE; NITRIC-OXIDE;
   METABOLIC SYNDROME; OXIDATIVE STRESS; NATRIURETIC-PEPTIDE;
   GUANYLATE-CYCLASE; REDOX REGULATION; ALDOSTERONE; HOMOCYSTEINE;
   DYSFUNCTION
AB Introduction: COVID-19 is a novel and devastating disease. Its manifestations vary from asymptomatic to lethal. Moreover, mortality rates differ based on underlying health conditions and ethnicity. We investigated the biochemical rationale behind these observations using machine reasoning by the system (). Facts were extracted and linked from publications available in nlm.nih.gov and Europe PMC to form the dataset which was validated by medical experts.
   Results: Based on the analysis of experimental and clinical data, we synthesized detailed biochemical pathways of COVID-19 pathogenesis which were used to explain epidemiological and clinical observations. Clinical manifestations and biomarkers are highlighted to monitor the course of COVID-19 and navigate treatment. As depicted in the Graphical Abstract, SARS-CoV-2 triggers a pro-oxidant (PO) response leading to the production of reactive oxygen species (ROS) as a normal innate defense. However, SARS-CoV-2's unique interference with the antioxidant (AO) system, through suppression of nitric oxide (NO) production in the renin- angiotensin-aldosterone system (RAAS), leads to an excessive inflammatory PO response. The excessive PO response becomes critical in cohorts with a compromised AO system such as patients with glucose-6-phosphate dehydrogenase deficiency (G6PDd) where NO and glutathione (GSH) mechanisms are impaired. G6PDd develops in patients with metabolic syndrome. It is mediated by aldosterone (Ald) which also increases specifically in COVID-19.
   Conclusion: G6PD is essential for an adequate immune response. Both G6PDd and SARS-CoV-2 compromise the AO system through the same pathways rendering G6PDd the Achilles' heel for COVID-19. Thus, the evolutionary antimalarial advantage of the G6PDd cohort can be a disadvantage against SARS-CoV-2.
C1 [Buinitskaya, Yuliya; Gurinovich, Roman] Sci AI, Tallinn, Estonia.
   [Wlodaver, Clifford G.] Oklahoma Univ, Hlth Sci Ctr, Oklahoma City, OK USA.
   [Kastsiuchenka, Siarhei] Cleveland Clin Abu Dhabi, Anesthesiol Inst, Abu Dhabi, U Arab Emirates.
C3 University of Oklahoma System; University of Oklahoma Health Sciences
   Center; Cleveland Clinic Foundation
RP Buinitskaya, Y (corresponding author), Sci AI, Tallinn, Estonia.
EM julia@sci.ai
OI Gurinovich, Roman/0000-0002-9985-9493; Buinitskaya,
   Yuliya/0000-0002-2746-3705
FU Digital Science through their Catalyst Grant program
FX This work was supported by Digital Science through their Catalyst Grant
   program. The funder was not involved in the study design, collection,
   analysis, interpretation of data, the writing of this article or the
   decision to submit it for publication.
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NR 82
TC 20
Z9 21
U1 0
U2 8
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 2296-858X
J9 FRONT MED-LAUSANNE
JI Front. Med.
PD OCT 22
PY 2020
VL 7
AR 584112
DI 10.3389/fmed.2020.584112
PG 11
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA OL6EK
UT WOS:000585430500001
PM 33195336
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Silvares, RR
   Pereira, ENGD
   Flores, EEI
   Rodrigues, KL
   Silva, AR
   Gonçalves-de-Albuquerque, CF
   Daliry, A
AF Silvares, Raquel Rangel
   Goulart da Silva Pereira, Evelyn Nunes
   Ilaquita Flores, Edgar Eduardo
   Rodrigues, Karine Lino
   Silva, Adriana Ribeiro
   Goncalves-de-Albuquerque, Cassiano Felipe
   Daliry, Anissa
TI High-fat diet-induced kidney alterations in rats with metabolic
   syndrome: endothelial dysfunction and decreased antioxidant defense
SO DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
LA English
DT Article
DE metabolic syndrome; kidney endothelial dysfunction; pyridoxamine;
   advanced glycation end products
ID GLYCATION END-PRODUCTS; PARADOXICAL VASOCONSTRICTION;
   DIABETIC-NEPHROPATHY; PYRIDOXAMINE K-163; LIPID-PEROXIDATION; DISEASE;
   OBESITY; MICROCIRCULATION; GLYCOSYLATION; INHIBITOR
AB Introduction: This study aimed to investigate changes in renal function and the AGE-RAGE axis in the kidney of a non-genetic animal model of metabolic syndrome (MetS) induced by high-fat diet (HFD). Additionally, we evaluated the protective effect of pyridoxamine (PM), a vitamin B6 analog with anti-AGE effects, in the context of diet-related renal endothelial dysfunction.
   Methodology: In Wistar rats, the MetS animal model was induced by 20 or 28 weeks of HFD feeding. When indicated, a subgroup of animals was treated daily with PM (60 mg/kg) for 2 months. Tissue perfusion in renal microcirculation was examined by laser speckle contrast imaging. Oxidative stress was analyzed by thiobarbituric acid reactive species and the inflammatory markers by ELISA (TNF-alpha and IL-1 beta). Reverse transcription polymerase chain reaction was used to analyze eNOs, IL-6, vascular cell adhesion molecule (VCAM), NADPH oxidase subunit 47 (N47), catalase, and receptor for AGE (RAGE) gene expression.
   Results: Wistar rats fed a HFD showed negligible alteration in renal function, decrease in catalase mRNA transcripts and catalase enzyme activity compared to control (CTL) animals. Increased levels of IL-1 beta were observed in the kidney of MetS-induced rats. HFD-fed rats exhibited kidney endothelial dysfunction, with no significant differences in basal microvascular blood flow. PM significantly improved kidney vasorelaxation in HFD-fed rats. eNOS, VCAM, and RAGE gene expression and AGE content were not altered in kidneys of HFD-induced MetS rats in comparison to CTLs.
   Conclusions: Our findings suggest that HFD-induced microvascular dysfunction precedes the decline in renal function, and could be related to antioxidant machinery defects and inflammation activation in the kidney. PM showed a vasoprotective effect, and thus, could be an important contributory factor in ameliorating diet-induced renal damage.
C1 [Silvares, Raquel Rangel; Goulart da Silva Pereira, Evelyn Nunes; Ilaquita Flores, Edgar Eduardo; Rodrigues, Karine Lino; Daliry, Anissa] Fundacao Oswaldo Cruz, Oswaldo Cruz Inst, Lab Cardiovasc Invest, Rio De Janeiro, RJ, Brazil.
   [Silva, Adriana Ribeiro; Goncalves-de-Albuquerque, Cassiano Felipe] Fundacao Oswaldo Cruz, Oswaldo Cruz Inst, Lab Immunopharmacol, Rio De Janeiro, RJ, Brazil.
   [Goncalves-de-Albuquerque, Cassiano Felipe] Fed Univ State Rio de Janeiro, Lab Immunopharmacol, Rio De Janeiro, RJ, Brazil.
C3 Fundacao Oswaldo Cruz; Fundacao Oswaldo Cruz
RP Daliry, A (corresponding author), Inst Oswaldo Cruz, FIOCRUZ, Pavilhao Ozorio Almeida, BR-21040360 Rio De Janeiro, RJ, Brazil.
EM daliry@ioc.fiocruz.br
RI Silva, Adriana/NBW-8392-2025; Daliry, Anissa/F-6256-2014;
   Goncalves-de-Albuquerque, Cassiano Felippe/N-2815-2014; Nunes Goulart da
   Silva Pereira, Evelyn/AAG-2711-2021
OI Daliry, Anissa/0000-0001-7303-0030; Goncalves-de-Albuquerque, Cassiano
   Felippe/0000-0002-4458-3055; Nunes Goulart da Silva Pereira,
   Evelyn/0000-0001-5511-7036; Ribeiro Silva, Adriana/0000-0002-5137-4251
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NR 47
TC 26
Z9 26
U1 0
U2 8
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-7007
J9 DIABET METAB SYND OB
JI Diabetes Metab. Syndr. Obes.
PY 2019
VL 12
BP 1773
EP 1781
DI 10.2147/DMSO.S211253
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA JC9UZ
UT WOS:000489623400001
PM 31564943
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Ahmed, CMS
   Jiang, HH
   Chen, JY
   Lin, YH
AF Ahmed, C. M. Sabbir
   Jiang, Huanhuan
   Chen, Jin Y.
   Lin, Ying-Hsuan
TI Traffic-Related Particulate Matter and Cardiometabolic Syndrome: A
   Review
SO ATMOSPHERE
LA English
DT Review
DE traffic-related air pollution; particulate matter; health effects;
   cardiovascular disease; metabolic syndrome; diabetes; obesity
ID POLYCYCLIC AROMATIC-HYDROCARBONS; AIR-POLLUTION EXPOSURE; LONG-TERM
   EXPOSURE; HEART-RATE-VARIABILITY; METABOLIC SYNDROME; DIESEL EXHAUST;
   CARDIOVASCULAR-DISEASE; DIABETES-MELLITUS; BLOOD-PRESSURE; PEROXISOME
   PROLIFERATOR
AB Traffic-related particulate matter (PM) is a major source of outdoor air pollution worldwide. It has been recently hypothesized to cause cardiometabolic syndrome, including cardiovascular dysfunction, obesity, and diabetes. The environmental and toxicological factors involved in the processes, and the detailed mechanisms remain to be explored. The objective of this study is to assess the current scientific evidence of traffic-related PM-induced cardiometabolic syndrome. We conducted a literature review by searching the keywords of traffic related air pollution, particulate matter, human health, and metabolic syndrome from 1980 to 2018. This resulted in 25 independent research studies for the final review. Both epidemiological and toxicological findings reveal consistent correlations between traffic-related PM exposure and the measured cardiometabolic health endpoints. Smaller sizes of PM, particularly ultrafine particles, are shown to be more harmful due to their greater concentrations, reactive compositions, longer lung retention, and bioavailability. The active components in traffic-related PM could be attributed to metals, black carbon, elemental carbon, polyaromatic hydrocarbons, and diesel exhaust particles. Existing evidence points out that the development of cardiometabolic symptoms can occur through chronic systemic inflammation and increased oxidative stress. The elderly (especially for women), children, genetically susceptible individuals, and people with pre-existing conditions are identified as vulnerable groups. To advance the characterization of the potential health risks of traffic-related PM, additional research is needed to investigate the detailed chemical compositions of PM constituents, atmospheric transformations, and the mode of action to induce adverse health effects. Furthermore, we recommend that future studies could explore the roles of genetic and epigenetic factors in influencing cardiometabolic health outcomes by integrating multi-omics approaches (e.g., genomics, epigenomics, and transcriptomics) to provide a comprehensive assessment of biological perturbations caused by traffic-related PM.
C1 [Ahmed, C. M. Sabbir; Chen, Jin Y.; Lin, Ying-Hsuan] Univ Calif Riverside, Environm Toxicol Grad Program, Riverside, CA 92521 USA.
   [Ahmed, C. M. Sabbir; Jiang, Huanhuan; Chen, Jin Y.; Lin, Ying-Hsuan] Univ Calif Riverside, Dept Environm Sci, Riverside, CA 92521 USA.
C3 University of California System; University of California Riverside;
   University of California System; University of California Riverside
RP Lin, YH (corresponding author), Univ Calif Riverside, Environm Toxicol Grad Program, Riverside, CA 92521 USA.; Lin, YH (corresponding author), Univ Calif Riverside, Dept Environm Sci, Riverside, CA 92521 USA.
EM cahme002@ucr.edu; hjiang@ucr.edu; jchen137@ucr.edu;
   ying-hsuan.lin@ucr.edu
RI Lin, Ying-Hsuan/J-4023-2014; Ahmed, C/AAF-6326-2021; Jiang,
   Huanhuan/B-9433-2019
OI Lin, Ying-Hsuan/0000-0001-8904-1287
FU University of California, Riverside (UCR) Regents' Faculty Fellowships
FX Ying-Hsuan Lin gratefully acknowledges support from the University of
   California, Riverside (UCR) Regents' Faculty Fellowships. We are
   thankful to Cody Cullen for his editorial assistance.
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NR 100
TC 25
Z9 28
U1 4
U2 58
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2073-4433
J9 ATMOSPHERE-BASEL
JI Atmosphere
PD SEP
PY 2018
VL 9
IS 9
AR 336
DI 10.3390/atmos9090336
PG 16
WC Environmental Sciences; Meteorology & Atmospheric Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Meteorology & Atmospheric Sciences
GA GX9PY
UT WOS:000448137500011
OA Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Johansen, D
   Stocks, T
   Jonsson, H
   Lindkvist, B
   Björge, T
   Concin, H
   Almquist, M
   Häggström, C
   Engeland, A
   Ulmer, H
   Hallmans, G
   Selmer, R
   Nagel, G
   Tretli, S
   Stattin, P
   Manjer, J
AF Johansen, Dorthe
   Stocks, Tanja
   Jonsson, Hakan
   Lindkvist, Bjorn
   Bjorge, Tone
   Concin, Hans
   Almquist, Martin
   Haggstrom, Christel
   Engeland, Anders
   Ulmer, Hanno
   Hallmans, Goran
   Selmer, Randi
   Nagel, Gabriele
   Tretli, Steinar
   Stattin, Par
   Manjer, Jonas
TI Metabolic Factors and the Risk of Pancreatic Cancer: A Prospective
   Analysis of almost 580,000 Men and Women in the Metabolic Syndrome and
   Cancer Project
SO CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
LA English
DT Article
ID BODY-MASS INDEX; INSULIN-RESISTANCE; REGRESSION DILUTION;
   PHYSICAL-ACTIVITY; OXIDATIVE STRESS; FOLLOW-UP; SMOKING; GLUCOSE;
   COHORT; POPULATION
AB Background: The aim of this study was to investigate the association between factors in metabolic syndrome (MetS; single and combined) and the risk of pancreatic cancer.
   Methods: The Metabolic Syndrome and Cancer Project is a pooled cohort containing data on body mass index, blood pressure, and blood levels of glucose, cholesterol, and triglycerides. During follow-up, 862 individuals were diagnosed with pancreatic cancer. Cox proportional hazards analysis was used to calculate relative risks (RR) with 95% confidence intervals using the abovementioned factors categorized into quintiles and transformed into z-scores. All z-scores were summarized and a second z-transformation creating a composite z-score for MetS was done. All risk estimates were calibrated to correct for a regression dilution bias.
   Results: The trend over quintiles was positively associated with the risk of pancreatic cancer for mid-blood pressure (mid-BP) and glucose in men and for body mass index, mid-BP, and glucose in women. The z-score for the adjusted mid-BP (RR, 1.10; 1.01-1.20) and the calibrated z-score for glucose (RR, 1.37; 1.14-1.34) were positively associated with pancreatic cancer in men. In women, a positive association was found for calibrated z-scores for mid-BP (RR, 1.34; 1.08-1.66), for the calibrated z-score for glucose (RR, 1.98; 1.41-2.76), and for the composite z-score for MetS (RR, 1.58; 1.34-1.87).
   Conclusion: Our study adds further evidence to a possible link between abnormal glucose metabolism and risk of pancreatic cancer.
   Impact: To our knowledge, this is the first study on MetS and pancreatic cancer using prediagnostic measurements of the examined factors. Cancer Epidemiol Biomarkers Prev; 19(9); 2307-17. (C) 2010 AACR.
C1 [Johansen, Dorthe] Lund Univ, Skane Univ Hosp, Dept Surg, SUS, SE-20502 Malmo, Sweden.
   [Stocks, Tanja; Haggstrom, Christel; Stattin, Par] Umea Univ, Dept Surg & Perioperat Sci, Umea, Sweden.
   [Stocks, Tanja] Vrije Univ Amsterdam, Inst Hlth Sci, Amsterdam, Netherlands.
   [Jonsson, Hakan] Umea Univ, Dept Radiat Sci, Umea, Sweden.
   [Lindkvist, Bjorn] Sahlgrens Univ Hosp, Div Gastroenterol & Hepatol, Dept Internal Med, Gothenburg, Sweden.
   [Bjorge, Tone; Engeland, Anders; Selmer, Randi] Norwegian Inst Publ Hlth, Oslo, Norway.
   [Concin, Hans] Agcy Prevent & Social Med, Bregenz, Austria.
   [Ulmer, Hanno] Innsbruck Med Univ, Dept Med Stat Informat & Hlth Econ, Innsbruck, Austria.
   [Hallmans, Goran] Umea Univ, Dept Publ Hlth & Clin Med, Umea, Sweden.
   [Nagel, Gabriele] Univ Ulm, Inst Epidemiol, Ulm, Germany.
   [Tretli, Steinar] Canc Registry Norway, Inst Population Based Canc Res, Oslo, Norway.
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C3 Lund University; Skane University Hospital; Umea University; Vrije
   Universiteit Amsterdam; Umea University; Sahlgrenska University
   Hospital; Norwegian Institute of Public Health (NIPH); Medical
   University of Innsbruck; Umea University; Ulm University; University of
   Oslo; University of Bergen; Lund University
RP Johansen, D (corresponding author), Lund Univ, Skane Univ Hosp, Dept Surg, SUS, SE-20502 Malmo, Sweden.
EM dorthe.johansen@med.lu.se
RI Engeland, Anders/AAG-7437-2021; Ulmer, Hanno/S-6615-2019; Cífková,
   Renata/O-5731-2017; Stocks, Tanja/HPE-5538-2023; Nagel,
   Gabriele/C-3635-2012; Almquist, Martin/H-7209-2019
OI Almquist, Martin/0000-0002-0953-1188; Lindkvist,
   Bjorn/0000-0001-7485-0006; Bjorge, Tone/0000-0002-9096-5257; Ulmer,
   Hanno/0000-0001-5911-1002
FU World Cancer Research Fund [2007/09]; Swedish Research Council; Ernhold
   Lundstrom Foundation; Einar and Inga Nilsson Foundation; Malmo
   University Hospital; Crafoord Foundation; Mossfelt Foundation
FX World Cancer Research Fund (grant 2007/09), The Swedish Research
   Council, The Ernhold Lundstrom Foundation, The Einar and Inga Nilsson
   Foundation, The Malmo University Hospital Cancer Research Fund, The
   Malmo University Hospital Funds and Donations, The Crafoord Foundation,
   and The Mossfelt Foundation.
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NR 48
TC 92
Z9 103
U1 0
U2 9
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 1055-9965
EI 1538-7755
J9 CANCER EPIDEM BIOMAR
JI Cancer Epidemiol. Biomarkers Prev.
PD SEP
PY 2010
VL 19
IS 9
BP 2307
EP 2317
DI 10.1158/1055-9965.EPI-10-0234
PG 11
WC Oncology; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Public, Environmental & Occupational Health
GA 648HS
UT WOS:000281683800021
PM 20826833
OA Green Submitted, Bronze
DA 2025-06-11
ER

PT J
AU Ye, W
   Wen, CW
   Zeng, AB
   Hu, XZ
AF Ye, Wei
   Wen, Chaowei
   Zeng, Aibing
   Hu, Xingzhong
TI Increased levels of circulating oxidized mitochondrial DNA contribute to
   chronic inflammation in metabolic syndrome, and MitoQ-based antioxidant
   therapy alleviates this DNA-induced inflammation
SO MOLECULAR AND CELLULAR ENDOCRINOLOGY
LA English
DT Article
DE Metabolic syndrome; Inflammation; Mitochondrial DNA; Toll -like receptor
   9; MitoQ
ID NLRP3 INFLAMMASOME; OXIDATIVE STRESS; DYSFUNCTION; ACTIVATION; IMMUNITY;
   PATHWAY; INJURY
AB Here, the aim was to investigate the role of circulating oxidized mitochondrial DNA (ox-mtDNA) in metabolic syndrome (MetS)-associated chronic inflammation and evaluate the effect of Mito-Quinone (MitoQ)-based antioxidant therapy on inflammation. A total of 112 MetS patients and 111 healthy control individuals (HCs) were recruited. Peripheral blood was collected, and mononuclear cells (PBMCs) were separated. In a preclinical study, MitoQ, a mitochondrial-targeted antioxidant, was administered to Sprague-Dawley (SD) rats fed a high-fat diet (HFD). In vitro, H2O2- or MitoQ-treated HUVECs served as the oxidative or antioxidative cell models to detect the cell-free ox-mtDNA level. Plasma or cell-free ox-mtDNA levels were measured by qPCR. Additionally, THP-1 cells were incubated with plasma cell-free DNA (cfDNA) from MetS patients and HCs or cell-free ox-mtDNA to detect TLR9-NF-kappa B pathway activation. Plasma ox-mtDNA levels and TLR9 expression levels in PBMCs were increased in MetS patients. In vivo, HFD-fed rats showed elevated plasma ox-mtDNA and TLR9 expression levels in cardiac-residing immune cells, but MitoQ administration attenuated these increases. In vitro, a significant lower level of cell-free ox-mtDNA was detected in MitoQ-treated cells, compared with H2O2-treated cells. Coincubation of plasma cfDNA from MetS patients or cell-free ox-mtDNA and THP-1 cells increased TLR9-NF-kappa B p65 expression, and promoted IL-1 beta, IL-6 and IL-8 secretion in THP-1 cells. In conclusion, increased circulating ox-mtDNA contributes to chronic inflammation in MetS by activating the TLR9-NF-kappa B pathway. MitoQ-based antioxidant therapy effectively alleviates inflammation by reducing ox-mtDNA release.
C1 [Ye, Wei; Wen, Chaowei; Zeng, Aibing] Wenzhou Med Univ, Sch Lab Med & Life Sci, Wenzhou 325035, Zhejiang, Peoples R China.
   [Hu, Xingzhong] Wenzhou Med Univ, Wenzhou Cent Hosp, Dingli Clin Sch, Dept Clin Lab Med, Wenzhou 325000, Peoples R China.
   [Ye, Wei] Wenzhou Med Univ, Chashan Univ Town, Wenzhou 325035, Zhejiang, Peoples R China.
C3 Wenzhou Medical University; Wenzhou Medical University; Wenzhou Medical
   University
RP Ye, W (corresponding author), Wenzhou Med Univ, Chashan Univ Town, Wenzhou 325035, Zhejiang, Peoples R China.
EM yw415@wmu.edu.cn
OI Ye, Wei/0000-0002-9595-7811
FU Zhejiang Provincial Natural Science Foundation of China [LQ18H020005,
   LGF21C010002]; Medical and Health Research Project of Zhejiang Province
   of China [2018KY507, 2018KY508]
FX We thank the Medical Imaging Center of the First Affiliated Hospital of
   Wenzhou Medical University. This work was supported by the Zhejiang
   Provincial Natural Science Foundation of China under Grant No.
   LQ18H020005 and LGF21C010002 and the Medical and Health Research Project
   of Zhejiang Province of China under Grant No.2018KY507 and 2018KY508.
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NR 51
TC 8
Z9 8
U1 1
U2 8
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0303-7207
EI 1872-8057
J9 MOL CELL ENDOCRINOL
JI Mol. Cell. Endocrinol.
PD JAN 15
PY 2023
VL 560
AR 111812
DI 10.1016/j.mce.2022.111812
EA NOV 2022
PG 13
WC Cell Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Endocrinology & Metabolism
GA 7O9LD
UT WOS:000908335600001
PM 36334615
DA 2025-06-11
ER

PT J
AU Sakhaei, F
   Keshvari, M
   Asgary, S
   Salehizadeh, L
   Rastqar, A
   Samsam-Shariat, SZ
AF Sakhaei, Fariba
   Keshvari, Mahtab
   Asgary, Sedigheh
   Salehizadeh, Leila
   Rastqar, Ali
   Samsam-Shariat, Seyyed Ziaedin
TI Enzymatic antioxidant system and endothelial function in patients with
   metabolic syndrome
SO ARYA ATHEROSCLEROSIS
LA English
DT Article
DE Glutathione Peroxidase-1; Endothelium; Enzyme Activity; Metabolic
   Syndrome
ID OXIDATIVE STRESS; INSULIN-RESISTANCE; FAT OVERLOAD; RISK-FACTORS;
   GLUTATHIONE; BLOOD; DYSFUNCTION
AB BACKGROUND: This study examined the relationship between serum glutathione peroxidase 1 (GPx-1) activity and endothelial dysfunction in the subjects with and without metabolic syndrome (MetS).
   METHODS: This case-control study was conducted on 76 subjects, 38 were patients with MetS and 38 were without MetS. The demographic, clinical, and laboratory features of the subjects were measured and then compared. The MetS was diagnosed according to the definitions of the National Cholesterol Education Program (NCEP) and International Diabetes Federation (IDF). Serum GPx-1 activity was measured by standard methods. Endothelial dysfunction was assessed with flow-mediated dilation (FMD) technique.
   RESULTS: In case-control study of 76 subjects, all of MetS risk factors including abdominal obesity, triglyceride (TG), low serum level of high-density lipoprotein cholesterol (HDL-C), hypertension (HTN), and fasting plasma glucose (FPG) were significantly higher than healthy individuals (P < 0.050). FMD was significantly lower than normal subjects (P < 0.050). Serum GP-1 activity was significantly lower in patients with MetS compared to normal subjects (21.7 +/- 13.5 vs. 79.0 +/- 38.6, respectively) (P = 0.001). The value of GPx-1 was significantly correlated with diastolic blood pressure (DBP) (r = -0.249, P = 0.040), C-reactive protein (CRP) (r = -0.409, P = 0.014), and FMD (r = 0.293, P = 0.050) in patients with MetS. The results of logistic regression showed that a unite increase in CRP (mg/dl), FMD (%), and endothelin-1 (ET-1) (pg/ml) and a unit decrease in GPx significantly increased the odds ratio (OR) of MetS; after adjusting for age and sex the results remained significant except for FMD (P < 0.050)
   CONCLUSION: Endothelial dysfunction is related to serum GPx-1 activity in patients with MetS. GPX-1 activity is associated with risk of cardiovascular diseases (CVDs) and peripheral vascular diseases (PVDs) in patients with MetS.
C1 [Sakhaei, Fariba; Samsam-Shariat, Seyyed Ziaedin] Isfahan Univ Med Sci, Isfahan Pharmaceut Sci Res Ctr, Sch Pharm & Pharmaceut Sci, Esfahan, Iran.
   [Sakhaei, Fariba; Samsam-Shariat, Seyyed Ziaedin] Isfahan Univ Med Sci, Dept Clin Biochem, Sch Pharm & Pharmaceut Sci, Esfahan, Iran.
   [Keshvari, Mahtab; Asgary, Sedigheh] Isfahan Univ Med Sci, Isfahan Cardiovasc Res Ctr, Cardiovasc Res Inst, Esfahan, Iran.
   [Salehizadeh, Leila] Isfahan Univ Med Sci, Cardiac Rehabil Res Ctr, Cardiovasc Res Inst, Esfahan, Iran.
   [Rastqar, Ali] Laval Univ, Dept Psychiat & Neurosci, Quebec City, PQ, Canada.
C3 Isfahan University of Medical Sciences; Isfahan University of Medical
   Sciences; Isfahan University of Medical Sciences; Isfahan University of
   Medical Sciences; Laval University
RP Samsam-Shariat, SZ (corresponding author), Isfahan Univ Med Sci, Isfahan Pharmaceut Sci Res Ctr, Sch Pharm & Pharmaceut Sci, Esfahan, Iran.; Samsam-Shariat, SZ (corresponding author), Isfahan Univ Med Sci, Dept Clin Biochem, Sch Pharm & Pharmaceut Sci, Esfahan, Iran.
EM samsam@pharm.mui.ac.ir
RI keshvari, mahtab/ABD-4038-2020
FU Department of Clinical Biochemistry, Isfahan Pharmaceutical Sciences
   Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan
   University of Medical Sciences
FX The authors would like to thank the internship colleagues at Department
   of Clinical Biochemistry, Isfahan Pharmaceutical Sciences Research
   Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan
   University of Medical Sciences for their wonderful collaboration. This
   work was supported by the Department of Clinical Biochemistry, Isfahan
   Pharmaceutical Sciences Research Center, School of Pharmacy and
   Pharmaceutical Sciences, Isfahan University of Medical Sciences.
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NR 45
TC 9
Z9 11
U1 0
U2 3
PU ISFAHAN UNIV MEDICAL SCIENCES, ISFAHAN CARDIOVASCULAR RES CENTER
PI ISAFAHAN
PA PO BOX 81465-1148, ISAFAHAN, REPUBLIC ISLAMIC 00000, IRAN
SN 1735-3955
EI 2251-6638
J9 ARYA ATHEROSCLER
JI ARYA Atheroscler.
PD MAR
PY 2020
VL 16
IS 2
BP 94
EP 101
DI 10.22122/arya.v16i2.1813
PG 8
WC Cardiac & Cardiovascular Systems
WE Emerging Sources Citation Index (ESCI)
SC Cardiovascular System & Cardiology
GA OK9NQ
UT WOS:000584970900006
PM 33133208
DA 2025-06-11
ER

PT J
AU Yu, TY
   Jin, SM
   Jee, JH
   Bae, JC
   Lee, MK
   Kim, JH
AF Yu, Tae Yang
   Jin, Sang-Man
   Jee, Jae Hwan
   Bae, Ji Cheol
   Lee, Moon-Kyu
   Kim, Jae Hyeon
TI The Protective Effects of Increasing Serum Uric Acid Level on
   Development of Metabolic Syndrome
SO DIABETES & METABOLISM JOURNAL
LA English
DT Article
DE Longitudinal studies; Metabolic syndrome; Uric acid
ID CHRONIC HEART-FAILURE; OXIDATIVE STRESS; INDEPENDENT PREDICTOR;
   ANTIOXIDANT CAPACITY; XANTHINE-OXIDASE; HEALTHY; PEROXYNITRITE;
   SCAVENGER; WOMEN
AB Background: It has not been determined whether changes in serum uric acid (SUA) level are associated with incident metabolic syndrome (MetS). The aim of the current study was to investigate the relationship between changes in SUA level and development of MetS in a large number of subjects.
   Methods: In total, 13,057 subjects participating in a medical health check-up program without a diagnosis of MetS at baseline were enrolled. Cox proportional hazards models were used to test the independent association of percent changes in SUA level with development of MetS.
   Results: After adjustment for age, systolic blood pressure, body mass index, fat-free mass (%), estimated glomerular filtration rate, smoking status, fasting glucose, triglyceride, low density lipoprotein cholesterol, high density lipoprotein cholesterol, and baseline SUA levels, the hazard ratios (HRs) (95% confidence intervals [CIs]) for incident MetS in the second, third, and fourth quartiles compared to the first quartile of percent change in SUA level were 1.055 (0.936 to 1.190), 0.927 (0.818 to 1.050), and 0.807 (0.707 to 0.922) in male (P for trend <0.001) and 1.000 (0.843 to 1.186), 0.744 (0.615 to 0.900), and 0.684 (0.557 to 0.840) in female (P for trend <0.001), respectively. As a continuous variable in the fully-adjusted model, each one-standard deviation increase in percent change in SUA level was associated with an HR (95% CI) for incident MetS of 0.944 (0.906 to 0.982) in male (P=0.005) and 0.851 (0.801 to 0.905) in female (P <0.001).
   Conclusion: The current study demonstrated that increasing SUA level independently protected against the development of MetS, suggesting a possible role of SUA as an antioxidant in the pathogenesis of incident MetS.
C1 [Yu, Tae Yang] Wonkwang Univ, Wonkwang Med Ctr, Dept Med, Div Endocrinol & Metab,Sch Med, Iksan, South Korea.
   [Yu, Tae Yang] Sungkyunkwan Univ, Dept Med, Grad Sch Med, Seoul, South Korea.
   [Jin, Sang-Man; Lee, Moon-Kyu; Kim, Jae Hyeon] Sungkyunkwan Univ, Samsung Med Ctr, Sch Med, Div Endocrinol & Metab,Dept Med, 81 Irwon-Ro, Seoul 06351, South Korea.
   [Jee, Jae Hwan] Sungkyunkwan Univ, Samsung Med Ctr, Sch Med, Dept Hlth Promot Ctr, Seoul, South Korea.
   [Bae, Ji Cheol] Sungkyunkwan Univ, Samsung Changwon Hosp, Dept Med, Div Endocrinol & Metab,Sch Med, Chang Won, South Korea.
   [Kim, Jae Hyeon] Samsung Med Ctr, Samsung Biomed Res Inst, Seoul, South Korea.
   [Kim, Jae Hyeon] Sungkyunkwan Univ, Samsung Adv Inst Hlth Sci & Technol, Dept Clin Res Design & Evaluat, Seoul, South Korea.
C3 Wonkwang University; Sungkyunkwan University (SKKU); Sungkyunkwan
   University (SKKU); Samsung Medical Center; Sungkyunkwan University
   (SKKU); Samsung Medical Center; Sungkyunkwan University (SKKU); Samsung
   Medical Center; Sungkyunkwan University (SKKU); Samsung Medical Center;
   Sungkyunkwan University (SKKU); Samsung Medical Center
RP Kim, JH (corresponding author), Sungkyunkwan Univ, Samsung Med Ctr, Sch Med, Div Endocrinol & Metab,Dept Med, 81 Irwon-Ro, Seoul 06351, South Korea.
EM jaehyeon@skku.edu
RI Kim, Ji/AAN-5655-2021; Jin, Sang-Man/AFO-5933-2022
OI Kim, Jae Hyeon/0000-0001-5001-963X; Jin, Sang-Man/0000-0001-5929-3627;
   Yu, Tae Yang/0000-0003-0893-592X
FU Wonkwang University
FX This study was supported by a grant from Wonkwang University in 2018.
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NR 30
TC 15
Z9 17
U1 0
U2 6
PU KOREAN DIABETES ASSOC
PI SEOUL
PA 101-2104, LOTTE CASTLE PRES, 109 MAPO-DAERO, MAPO-GU, SEOUL, 04146,
   SOUTH KOREA
SN 2233-6079
EI 2233-6087
J9 DIABETES METAB J
JI Diabetes Metab. J.
PD AUG
PY 2019
VL 43
IS 4
BP 504
EP 520
DI 10.4093/dmj.2018.0079
PG 17
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA IS5XL
UT WOS:000482226400012
PM 30877704
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Uchinaka, A
   Yoneda, M
   Yamada, Y
   Murohara, T
   Nagata, K
AF Uchinaka, Ayako
   Yoneda, Mamoru
   Yamada, Yuichiro
   Murohara, Toyoaki
   Nagata, Kohzo
TI Effects of mTOR inhibition on cardiac and adipose tissue pathology and
   glucose metabolism in rats with metabolic syndrome
SO PHARMACOLOGY RESEARCH & PERSPECTIVES
LA English
DT Article
DE Adipose tissue; cardiac remodeling; glucose metabolism; mammalian target
   of rapamycin; metabolic syndrome
ID PANCREATIC BETA-CELLS; DIASTOLIC DYSFUNCTION; MAMMALIAN TARGET;
   PROTEIN-KINASE; RAPAMYCIN; HYPERTROPHY; PATHWAY; GROWTH; MODEL; AKT
AB The mammalian target of rapamycin (mTOR) is a regulator of metabolism and is implicated in pathological conditions such as obesity and diabetes. We aimed to investigate the role of mTOR in obesity. A new animal model of metabolic syndrome (MetS), named DahlS.Z-Lepr(fa)/Lepr(fa) (DS/obese) rats was established previously in our laboratory. In this study, we used this model to evaluate the effects of mTOR inhibition on cardiac and adipose tissue pathology and glucose metabolism. DS/obese rats were treated with the mTOR inhibitor, everolimus, (0.83mg/kg per day, per os) for 4weeks at 9weeks of age. Age-matched homozygous lean (DahlS.Z-Lepr(+)/Lepr(+) or DS/lean) littermates of DS/obese rats were used as controls. Treatment with everolimus ameliorated hypertension, left ventricular (LV) hypertrophy and fibrosis, and LV diastolic dysfunction, and attenuated cardiac oxidative stress and inflammation in DS/obese rats, but had no effect on these parameters in DS/lean rats. Treatment with everolimus reduced Akt Thr308 phosphorylation in the heart of DS/obese rats. It also alleviated obesity, hyperphagia, adipocyte hypertrophy, and adipose tissue inflammation in DS/obese rats. Everolimus treatment exacerbated glucose intolerance, but did not affect Akt phosphorylation levels in the fat or liver in these rats. Pancreatic beta-cell mass was increased in DS/obese rats compared with that in DS/lean rats and this effect was attenuated by everolimus. Activation of mTOR signaling contributes to the pathophysiology of MetS and its associated complications. And mTOR inhibition with everolimus ameliorated obesity as well as cardiac and adipose tissue pathology, but exacerbated glucose metabolism in rats with MetS.
C1 [Uchinaka, Ayako; Yoneda, Mamoru; Yamada, Yuichiro; Nagata, Kohzo] Nagoya Univ, Grad Sch Med, Dept Pathophysiol Lab Sci, Nagoya, Aichi, Japan.
   [Murohara, Toyoaki] Nagoya Univ, Grad Sch Med, Dept Cardiol, Nagoya, Aichi, Japan.
C3 Nagoya University; Nagoya University
RP Nagata, K (corresponding author), Nagoya Univ, Grad Sch Med, Dept Pathophysiol Lab Sci, Higashi Ku, 1-1-20 Daikominami, Nagoya, Aichi 4618673, Japan.
EM nagata@met.nagoya-u.ac.jp
FU University-industry cooperation between Nagoya University and Novartis
   Pharma K. K. (Tokyo, Japan) [6115J0301b]
FX This work was supported by an entrusted research fund (No. 6115J0301b)
   from the University-industry cooperation between Nagoya University and
   Novartis Pharma K. K. (Tokyo, Japan).
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NR 37
TC 15
Z9 15
U1 0
U2 11
PU JOHN WILEY & SONS LTD
PI CHICHESTER
PA THE ATRIUM, SOUTHERN GATE, CHICHESTER PO19 8SQ, W SUSSEX, ENGLAND
SN 2052-1707
J9 PHARMACOL RES PERSPE
JI Pharmacol. Res. Perspect.
PD AUG
PY 2017
VL 5
IS 4
AR e00331
DI 10.1002/prp2.331
PG 14
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA FD3QK
UT WOS:000407447300010
PM 28805979
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Tagzirt, M
   Corseaux, D
   Pasquesoone, L
   Mouquet, F
   Roma-Lavisse, C
   Ung, A
   Lorenzi, R
   Jude, B
   Elkalioubie, A
   Van Belle, E
   Susen, S
   Dupont, A
AF Tagzirt, Madjid
   Corseaux, Delphine
   Pasquesoone, Louise
   Mouquet, Frederic
   Roma-Lavisse, Charlotte
   Ung, Alexandre
   Lorenzi, Rodrigo
   Jude, Brigitte
   Elkalioubie, Ahmed
   Van Belle, Eric
   Susen, Sophie
   Dupont, Annabelle
TI Alterations in Neutrophil Production and Function at an Early Stage in
   the High-Fructose Rat Model of Metabolic Syndrome
SO AMERICAN JOURNAL OF HYPERTENSION
LA English
DT Article
DE blood pressure; fructose; hypertension; metabolic syndrome; neutrophils;
   rat
ID NADPH OXIDASE ACTIVATION; SPRAGUE-DAWLEY RATS; INSULIN-RESISTANCE;
   HIGH-FAT; OXIDATIVE STRESS; CARDIOVASCULAR-DISEASE; BLOOD-PRESSURE;
   VISCERAL FAT; INFLAMMATION; ADIPONECTIN
AB BACKGROUND
   Although neutrophils are crucially involved in inflammation, they have received only little attention in metabolic syndrome (MetS). We hypothesized that neutrophil infiltration into adipose tissue (AT) may occur at an early stage of MetS, in association with modulation of major functions of neutrophils and of their bone marrow production.
   METHODS
   Fifty-six male Sprague-Dawley rats were fed regular (control rats (CRs)) or high-fructose (60%; fructose-fed rats (FFRs)) diets. After 6 weeks, metabolic parameters were measured. Distribution of neutrophils into AT was investigated by immunohistochemistry. Function of circulating neutrophils (activation, reactive oxygen species production, phagocytosis, and apoptosis) was determined by flow cytometry. Granulopoiesis was evaluated by measuring the number and survival characteristics of neutrophil progenitors using bone marrow culture assays and flow cytometry.
   RESULTS Compared with the CR group, the FFR group developed MetS (i.e., arterial hypertension, hypertriglyceridemia, fasting hyperglycemia, and greater intra-abdominal AT volume) and presented higher neutrophil infiltration into AT. At resting state, no significant difference for circulating neutrophil functions was observed between the 2 groups. In contrast, circulating neutrophils from the FFR group exhibited higher responses to phorbol-12-myristate-13-acetate for all studied functions, compared with the CR group, suggesting that early MetS induces neutrophil priming. In parallel, a diminished clonal capacity and an increased apoptosis in bone marrow-derived granulocyte progenitors and neutrophil precursors were observed in the FFR group compared with the CR group.
   CONCLUSIONS
   These results provide evidence of an increased infiltration into intra-abdominal AT and modified production, function, and phenotype of neutrophils at an early stage of high-fructose diet-induced MetS.
C1 [Tagzirt, Madjid; Corseaux, Delphine; Pasquesoone, Louise; Mouquet, Frederic; Roma-Lavisse, Charlotte; Ung, Alexandre; Lorenzi, Rodrigo; Jude, Brigitte; Elkalioubie, Ahmed; Van Belle, Eric; Susen, Sophie; Dupont, Annabelle] UDSL, Univ Lille Nord France, EA 2693, Lille, France.
   [Jude, Brigitte; Van Belle, Eric; Susen, Sophie] Univ Hosp, Cardiovasc & Pulm Dept, Lille, France.
   [Jude, Brigitte; Van Belle, Eric; Susen, Sophie] Univ Hosp, Dept Hematol, Lille, France.
C3 Universite de Lille; Universite de Lille; CHU Lille; Universite de
   Lille; CHU Lille
RP Dupont, A (corresponding author), UDSL, Univ Lille Nord France, EA 2693, Lille, France.
EM annabelle.dupont-2@univ-lille2.fr
RI susen, sophie/G-4337-2018; dupont, annabelle/K-5890-2013; Mouquet,
   Frederic/P-6899-2019; Corseaux, Delphine/R-4360-2018; TAGZIRT,
   Madjid/R-8048-2018
OI Lorenzi, Rodrigo/0000-0001-7676-7636; Corseaux,
   Delphine/0000-0001-8642-1508; TAGZIRT, Madjid/0000-0001-7914-0695; VAN
   BELLE, ERIC/0000-0001-6509-443X; Susen, Sophie/0000-0001-5953-163X
FU Contrat Plan Etat Region Nord Pas de Calais Cardiodiabete [2009-2010]
FX This work was supported by Contrat Plan Etat Region Nord Pas de Calais
   Cardiodiabete 2009-2010 grant. We gratefully thank B. Vaast for his
   excellent technical assistance.
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NR 40
TC 8
Z9 11
U1 0
U2 6
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0895-7061
EI 1941-7225
J9 AM J HYPERTENS
JI Am. J. Hypertens.
PD AUG
PY 2014
VL 27
IS 8
BP 1096
EP 1104
DI 10.1093/ajh/hpu021
PG 9
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA AP7DL
UT WOS:000342237900021
PM 25103937
OA Bronze
DA 2025-06-11
ER

PT J
AU Zulet, MA
   Bondia-Pons, I
   Abete, I
   de la Iglesia, R
   López-Legarrea, P
   Forga, L
   Navas-Carretero, S
   Martínez, JA
AF Zulet, Ma A.
   Bondia-Pons, I.
   Abete, I.
   de la Iglesia, R.
   Lopez-Legarrea, P.
   Forga, L.
   Navas-Carretero, S.
   Martinez, J. A.
TI The reduction of the metabolyc syndrome in Navarra-Spain (RESMENA-S)
   study; a multidisciplinary strategy based on chrononutrition and
   nutritional education, together with dietetic and psychological control
SO NUTRICION HOSPITALARIA
LA English
DT Article
DE Metabolic syndrome; Weight loss; Inflammation; Oxidative stress;
   Mediterranean diet
ID ENERGY-RESTRICTED DIETS; WEIGHT-LOSS; CALORIE RESTRICTION; HYPOCALORIC
   DIET; CARDIOVASCULAR RISK; OBESITY; INFLAMMATION; INDIVIDUALS;
   MAINTENANCE; VALIDATION
AB Introduction: The high prevalence of metabolic syndrome (MS) in Spain requires additional efforts for prevention and treatment.
   Objective: The study RESMENA-S aims to improve clinical criteria and biomarkers associated with MS though an integral therapy approach.
   Methods: The study is a randomized prospective parallel design in which is expected to participate a total of 100 individuals. The RESMENA-S group (n = 50) is a personalized weight loss (30% energy restriction) diet, with a macronutrient distribution (carbohydrate / fat / protein) of 40/30/30, high meal frequency (7 / day), low glycemic index/load and high antioxidant capacity as well as a high adherence to the Mediterranean diet. The control group (n = 50) is assigned to a diet with the same energy restriction and based on the American Heart Association pattern. Both experimental groups are under dietary and psychological control during 8 weeks. Likewise, for an additional period of 16 weeks of self-control, is expected that volunteers will follow the same pattern but with no dietary advice.
   Results: Anthropometrical data and body composition determinations as well as blood and urine samples are being collected at the beginning and end of each phase. This project is registered at www.clinicaltrials.gov with the number NCT01087086 and count with the Research Ethics Committee of the University of Navarra approval (065/2009).
   Conclusions: Intervention trials to promote the adoption of dietary patterns and healthy lifestyle are of great importance to identify the outcomes and nutritional mechanisms that might explain the link between obesity, metabolic syndrome and associated complications. (Nutr Hosp. 2011;26:16-26) DOI:10.3305/nh.2011.26.1.5050
C1 [Zulet, Ma A.; Bondia-Pons, I.; Abete, I.; de la Iglesia, R.; Lopez-Legarrea, P.; Navas-Carretero, S.; Martinez, J. A.] Univ Navarra, Dept Nutr Food Sci Physiol & Toxicol, Pamplona 31008, Spain.
   [Forga, L.] Hosp Navarra, Dept Endocrinol, Pamplona, Spain.
C3 University of Navarra; Servicio Navarro de Salud - Osasunbidea
RP Martínez, JA (corresponding author), Univ Navarra, Dept Nutr & Food Sci Physiol & Toxicol, Irunlarrea 1, Pamplona 31008, Spain.
EM jalfmtz@unav.es
RI de la Iglesia, Rocio/ABC-6189-2020; Martinez Hernandez, J
   Alfredo/K-8709-2014; Zulet, M. Angeles/H-1317-2017; Abete,
   Itziar/H-4827-2017; Navas-Carretero, Santiago/L-2918-2015
OI de la Iglesia, Rocio/0000-0002-7472-3565; Martinez Hernandez, J
   Alfredo/0000-0001-5218-6941; Zulet, M. Angeles/0000-0002-3926-0892;
   Abete, Itziar/0000-0002-6475-5387; Navas-Carretero,
   Santiago/0000-0002-5163-2230
FU Health Department of the Government of Navarra [2443/2009]; University
   of Navarra [LE/97]; Government of Navarra [028/02/09, 233/2009];
   Instituto Carlos III de Salud at the Spanish Ministry of Health
FX The authors wish to thank those members of the Nutritional Intervention
   Metabolic Unit, Veronica Ciaurriz (technical assistant), Maria Hernandez
   (Dietitian), Blanca Martinez de Morentin (physician) and Salome Perez
   (nurse) the collaboration in this project as well as to Department of
   Psychiatry and Medical Psychology/University of Navarra, Dra. Francisca
   Lahortiga and Clara Isabel Lacunza, for advice in psychological
   questionnaires. This work is supported by the Health Department of the
   Government of Navarra (2443/2009) and by Linea Especial about Nutrition,
   Obesity and Health (University of Navarra LE/97). Government of Navarra
   also provide research grants to Rocio de la Iglesia (Beca para la
   Formacion de Tecnologos n<SUP>o</SUP> 028/02/09) and Patricia Lopez
   Legarrea (Pre-doctoral n<SUP>o</SUP> 233/2009). Isabel Bondia-Pons is a
   recipient of a Sara Borrell postdoctoral fellowship from the Instituto
   Carlos III de Salud at the Spanish Ministry of Health.
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NR 58
TC 61
Z9 62
U1 0
U2 31
PU ARAN EDICIONES, S L
PI MADRID
PA C/ CASTELLO, 128, 1O, MADRID, 28006, SPAIN
SN 0212-1611
EI 1699-5198
J9 NUTR HOSP
JI Nutr. Hosp.
PD JAN-FEB
PY 2011
VL 26
IS 1
BP 16
EP 26
DI 10.3305/nh.2011.26.1.5050
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 729IX
UT WOS:000287943200002
PM 21519726
DA 2025-06-11
ER

PT J
AU Setola, E
   Monti, LD
   Galluccio, E
   Palloshi, A
   Fragasso, G
   Paroni, R
   Magni, F
   Sandoli, EP
   Lucotti, P
   Costa, S
   Fermo, I
   Galli-Kienle, M
   Origgi, A
   Margonato, A
   Piatti, P
AF Setola, E
   Monti, LD
   Galluccio, E
   Palloshi, A
   Fragasso, G
   Paroni, R
   Magni, F
   Sandoli, EP
   Lucotti, P
   Costa, S
   Fermo, I
   Galli-Kienle, M
   Origgi, A
   Margonato, A
   Piatti, P
TI Insulin resistance and endothelial function are improved after folate
   and vitamin B12 therapy in patients with metabolic syndrome:
   relationship between homocysteine levels and hyperinsulinemia
SO EUROPEAN JOURNAL OF ENDOCRINOLOGY
LA English
DT Article
ID NITRIC-OXIDE; FOLIC-ACID; ASYMMETRIC DIMETHYLARGININE; L-ARGININE;
   OXIDATIVE STRESS; SENSITIVITY; DYSFUNCTION; RISK;
   HYPERHOMOCYST(E)INEMIA; ASSOCIATION
AB Objective: The purpose of this study was (a) to study whether a folate and vitamin B12 treatment, aimed at decreasing homocysteine levels, might ameliorate insulin resistance and endothelial dysfunction in patients with metabolic syndrome according to the National Cholesterol Education Program-Adult Treatment Panel-III criteria and (b) to evaluate whether, under these metabolic conditions, there is a relationship between hyperhomocysteinemia and insulin resistance.
   Design and methods: A double-blind, parallel, identical placebo-drug, randomized study was performed for 2 months in 50 patients. Patients were randomly allocated to two groups. In group 1, patients were treated with diet plus placebo for 2 months. In group 2, patients were treated with diet plus placebo for 1. month, followed by diet plus folic acid (5mg/day) plus vitamin B12 (500 mug/day) for another month.
   Results: In group 2, folate treatment significantly decreased homocysteine levels by 27.8% (12.2 +/- 1.2 vs 8.8 +/- 0.7 mumol/l; P < 0.0 1). A significant decrement was observed for insulin levels (19.9 +/- 1.7 vs 14.8 +/- 1.6 muU/ml; P < 0.01) accompanied by a 27% reduction in the homeostasis model assessment levels. A positive relationship was found between the decrement of homocysteine and insulin levels (r = 0.60; P < 0.002). In parallel, endothelial dysfunction significantly improved in the treated group, since post-ischemic maximal hyperemic vasodilation increased by 29.8% and cGMP by 13.6% while asymmetrical dimethylarginine levels decreased by 21.7%. On the contrary, in group 1 patients, treated with placebo, no changes were shown in any of the variables.
   Conclusions: Folate and vitamin B12 treatment improved insulin resistance and endothelial dysfunction, along with decreasing homocysteine levels, in patients with metabolic syndrome, suggesting that folic acid has several beneficial effects on cardiovascular disease risk factors.
C1 Cardiovasc & Metab Rehabil Unit, Rehabil & Funct Reeducat Div, I-20132 Milan, Italy.
   Diabet Endocrinol Metab Dis Unit, Lab L20, Core Lab, Milan, Italy.
   Cardiothorac & Vasc Dept, Clin Cardiol Unit, Milan, Italy.
   Ist Sci San Raffaele, Dept Lab Med, I-20132 Milan, Italy.
   Univ Milan, Fac Med, Milan, Italy.
C3 Vita-Salute San Raffaele University; IRCCS Ospedale San Raffaele;
   University of Milan
RP Cardiovasc & Metab Rehabil Unit, Rehabil & Funct Reeducat Div, Via Olgettina 60, I-20132 Milan, Italy.
EM piermarco.piatti@hsr.it
RI Setola, Elisabetta/ABC-4357-2020; MARGONATO, ALBERTO/B-4185-2015; Monti,
   Lucilla/AAN-3716-2020; fermo, isabella/AAN-3999-2020; fragasso,
   gabriele/K-5483-2012; Galluccio, Elena/GQQ-1903-2022; Piatti,
   Piermarco/AAN-3115-2020; Magni, Fulvio/A-7340-2014; PARONI,
   RITA/C-2955-2012
OI fermo, isabella/0000-0003-2947-1933; Magni, Fulvio/0000-0002-8663-0374;
   Costa, Sabrina/0000-0001-9325-0882; PARONI, RITA/0000-0002-3186-8860
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NR 44
TC 124
Z9 135
U1 0
U2 9
PU BIOSCIENTIFICA LTD
PI BRISTOL
PA EURO HOUSE, 22 APEX COURT WOODLANDS, BRADLEY STOKE, BRISTOL BS32 4JT,
   ENGLAND
SN 0804-4643
EI 1479-683X
J9 EUR J ENDOCRINOL
JI Eur. J. Endocrinol.
PD OCT
PY 2004
VL 151
IS 4
BP 483
EP 489
DI 10.1530/eje.0.1510483
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 864NP
UT WOS:000224640500012
PM 15476449
OA Bronze
DA 2025-06-11
ER

PT J
AU Cifuentes, M
   Vahid, F
   Devaux, Y
   Bohn, T
AF Cifuentes, Miguel
   Vahid, Farhad
   Devaux, Yvan
   Bohn, Torsten
TI Biomarkers of food intake and their relevance to metabolic syndrome
SO FOOD & FUNCTION
LA English
DT Review
ID TRIMETHYLAMINE-N-OXIDE; FASTING PLASMA-CONCENTRATIONS; ALPHA-LINOLENIC
   ACID; WHOLE-GRAIN WHEAT; VITAMIN-E; LIQUID-CHROMATOGRAPHY;
   INTERINDIVIDUAL VARIABILITY; DIETARY SOURCES; FATTY-ACIDS; OLIVE OIL
AB Metabolic syndrome (MetS) constitutes a prevalent risk factor associated with non communicable diseases such as cardiovascular disease and type 2 diabetes. A major factor impacting the etiology of MetS is diet. Dietary patterns and several individual food constituents have been related to the risk of developing MetS or have been proposed as adjuvant treatment. However, traditional methods of dietary assessment such as 24 h recalls rely greatly on intensive user-interaction and are subject to bias. Hence, more objective methods are required for unbiased dietary assessment and efficient prevention. While it is accepted that some dietary-derived constituents in blood plasma are indicators for certain dietary patterns, these may be too unstable (such as vitamin C as a marker for fruits/vegetables) or too broad (e.g. polyphenols for plant-based diets) or reflect too short-term intake only to allow for strong associations with prolonged intake of individual food groups. In the present manuscript, commonly employed biomarkers of intake including those related to specific food items (e.g. genistein for soybean or astaxanthin and EPA for fish intake) and novel emerging ones (e.g. stable isotopes for meat intake or microRNA for plant foods) are emphasized and their suitability as biomarker for food intake discussed. Promising alternatives to plasma measures (e.g. ethyl glucuronide in hair for ethanol intake) are also emphasized. As many biomarkers (i.e. secondary plant metabolites) are not limited to dietary assessment but are also capable of regulating e.g. anti-inflammatory and antioxidant pathways, special attention will be given to biomarkers presenting a double function to assess both dietary patterns and MetS risk.
   To assess diet and the risk of metabolic syndrome, this review highlights food bioactives that are correlated with dietary intake. In addition, these bioactives have shown to impact systemic inflammation and oxidative stress, among other.
C1 [Cifuentes, Miguel; Vahid, Farhad; Devaux, Yvan; Bohn, Torsten] Luxembourg Inst Hlth, Dept Precis Hlth, Strassen, Luxembourg.
   [Cifuentes, Miguel] Univ Luxembourg, Doctoral Sch Sci & Engn, 2 Ave Univ, L-4365 Esch Sur Alzette, Luxembourg.
C3 Luxembourg Institute of Health; University of Luxembourg
RP Bohn, T (corresponding author), Luxembourg Inst Hlth, Dept Precis Hlth, Strassen, Luxembourg.
EM torsten.bohn@lih.lu
RI Cifuentes, Miguel/HTN-0818-2023; Bohn, Torsten/AAE-8393-2019; DEVAUX,
   Yvan/AAK-3463-2020; Vahid, Farhad/L-7547-2018
OI Devaux, Yvan/0000-0002-5321-8543; Bohn, Torsten/0000-0002-7825-0697;
   Vahid, Farhad/0000-0002-7380-3790; Cifuentes Acebal,
   Miguel/0000-0002-1517-2409
FU Fonds National de la Recherche Luxembourg
   [PRIDE21/16749720/NEXTIMMUNE2]; Luxembourg National Research Fund
FX The authors are grateful for the support of the Luxembourg National
   Research Fund (PRIDE21/16749720/NEXTIMMUNE2).
CR A. H. Association, WHOLE GRAINS REFINED
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NR 328
TC 5
Z9 5
U1 6
U2 12
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PD JUL 15
PY 2024
VL 15
IS 14
BP 7271
EP 7304
DI 10.1039/d4fo00721b
EA JUN 2024
PG 34
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA YU1Q3
UT WOS:001251309600001
PM 38904169
OA hybrid
DA 2025-06-11
ER

PT J
AU Yari, Z
   Movahedian, M
   Imani, H
   Alavian, SM
   Hedayati, M
   Hekmatdoost, A
AF Yari, Zahra
   Movahedian, Mina
   Imani, Hossein
   Alavian, Seyed Moayed
   Hedayati, Mehdi
   Hekmatdoost, Azita
TI The effect of hesperidin supplementation on metabolic profiles in
   patients with metabolic syndrome: a randomized, double-blind,
   placebo-controlled clinical trial
SO EUROPEAN JOURNAL OF NUTRITION
LA English
DT Article
DE Metabolic syndrome; Hesperidin; Metabolic abnormalities; Inflammatory
   biomarker
ID GLUCOSYL HESPERIDIN; FLAVONOID HESPERIDIN; INSULIN-RESISTANCE;
   SERUM-CHOLESTEROL; CITRUS FLAVONOIDS; OXIDATIVE STRESS; ALL-CAUSE;
   NARINGIN; INFLAMMATION; PLASMA
AB Purpose Hesperidin as an antioxidant flavonoid exerts anti-adipogenic, anti-inflammatory, anti-oxidant and anti-hypercholesterolemic effects. Besides, the increasing prevalence of metabolic syndrome (MetS) and its allied complications, on the one hand, and the willingness of individuals to use natural products for curing their diseases, on the other hand, led to the design of this study to evaluate the efficacy of hesperidin in normalizing the metabolic abnormalities in patients with MetS. Methods In this clinical trial with a parallel-group design, 49 patients with MetS received either 500-mg hesperidin or placebo, twice daily, for 12 weeks. Number of participants with treated MetS was considered as a primary end point. Anthropometric parameters, dietary intake, physical activity, lipid profile, glucose homeostasis parameter, tumor necrosis factor alpha (TNF-alpha), high-sensitivity C-reactive protein (hs-CRP) were assessed at the beginning and at the end of the study. This trial is registered at clinicaltrials.gov as NCT03734874. Results Compared with the placebo group, hesperidin decreased fasting glucose level (- 6.07 vs. - 13.32 mg/dL,P = 0.043), triglyceride (- 8.83 vs. - 49.09 mg/dL,P = 0.049), systolic blood pressure (- 0.58 vs. - 2.68 mmHg,P = 0.048) and TNF-alpha (- 1.29 vs. - 4.44 pg/mL,P = 0.009). Based on the within-group analysis, hesperidin led to significant decrease in serum levels of glucose, insulin, triglyceride, total cholesterol, low density lipoprotein cholesterol, TNF-alpha and hs-CRP, while in control group only glucose and insulin significantly decreased. Conclusions The results indicate that hesperidin supplementation can improve metabolic abnormalities and inflammatory status in patients with MetS.
C1 [Yari, Zahra] Shahid Beheshti Univ Med Sci, Natl Nutr & Food Technol Res Inst, Fac Nutr & Food Technol, Student Res Comm,Dept Clin Nutr & Dietet, Tehran, Iran.
   [Movahedian, Mina; Hekmatdoost, Azita] Shahid Beheshti Univ Med Sci, Fac Nutr Sci & Food Technol, Dept Clin Nutr & Dietet, Res Inst,Natl Nutr & Food Technol, Tehran, Iran.
   [Imani, Hossein] Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Clin Nutr, Tehran, Iran.
   [Alavian, Seyed Moayed] Middle East Liver Dis MELD Ctr, Tehran, Iran.
   [Hedayati, Mehdi] Shahid Beheshti Univ Med Sci, Res Inst Endocrine Sci, Cellular & Mol Endocrine Res Ctr, Tehran, Iran.
C3 Shahid Beheshti University Medical Sciences; Shahid Beheshti University
   Medical Sciences; Tehran University of Medical Sciences; Shahid Beheshti
   University Medical Sciences
RP Hekmatdoost, A (corresponding author), Shahid Beheshti Univ Med Sci, Fac Nutr Sci & Food Technol, Dept Clin Nutr & Dietet, Res Inst,Natl Nutr & Food Technol, Tehran, Iran.
EM Zahrayari_nut@yahoo.com; nutritionist1993@gmail.com;
   H-imani@sina.tums.ac.ir; Alavian@thc.ir; Hedayati@endocrine.ac.ir;
   Azita.Hekmatdoost@cw.bc.ca
RI Yari, Zahra/P-6594-2019; Ghorashi, Seyed/C-1529-2016; Movahedian,
   Mina/IWM-2701-2023; Imani, Hossein/AAU-7884-2020; Hedayati,
   Mehdi/AAG-3006-2019; Hekmatdoost, Azita/AGM-6497-2022
OI yari, zahra/0000-0003-2796-2413; Movahedian, Mina/0000-0001-8887-1385;
   Hekmatdoost, Azita/0000-0002-1944-0052
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NR 61
TC 42
Z9 43
U1 3
U2 16
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1436-6207
EI 1436-6215
J9 EUR J NUTR
JI Eur. J. Nutr.
PD SEP
PY 2020
VL 59
IS 6
BP 2569
EP 2577
DI 10.1007/s00394-019-02105-2
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA MW4ND
UT WOS:000557014800022
PM 31844967
DA 2025-06-11
ER

PT J
AU Chechi, K
   Yasui, N
   Ikeda, K
   Yamori, Y
   Cheema, SK
AF Chechi, Kanta
   Yasui, Naomi
   Ikeda, Katsumi
   Yamori, Yukio
   Cheema, Sukhinder K.
TI Flax oil-mediated activation of PPAR-γ correlates with reduction of
   hepatic lipid accumulation in obese spontaneously hypertensive/NDmcr-cp
   rats, a model of the metabolic syndrome
SO BRITISH JOURNAL OF NUTRITION
LA English
DT Article
DE Flax oil; Obese spontaneously hypertensive/NDmcr-cp rats; Hepatic
   lipids; PPAR-gamma expression
ID ALPHA-LINOLENIC ACID; POLYUNSATURATED FATTY-ACIDS; INDUCED
   INSULIN-RESISTANCE; GENE-EXPRESSION; PREVENTS TRANS-10; ADIPOSE-TISSUE;
   UP-REGULATION; LIVER; MICE; CHOLESTEROL
AB Flax oil feeding has been proposed to have beneficial effects on the outcome of the metabolic syndrome due to the high n-3 fatty acid content of flax oil; however, the mechanisms of its action remain largely unknown. We investigated the effects of flax oil feeding on hyperlipidaemia, hyperglycaemia, hepatic steatosis and oxidative stress in the spontaneously hypertensive (SHR)/NDmcr-cp rats, a genetic model of the metabolic syndrome. Hepatic gene expression of PPAR-alpha, PPAR-gamma and sterol-regulatory element-binding protein-1c was also assessed in order to investigate the possible underlying mechanisms. Obese and lean SHR/NDmcr-cp rats were fed high-fat diets enriched with either lard or flax oil for a period of 4 weeks. Obese rats exhibited higher body weight, liver weight and mesenteric fat-, epididymal fat-and renal fat-pad weights, and also TAG and cholesterol concentrations in serum and VLDL, LDL and HDL fractions, when compared with the lean rats (P<0.001), irrespective of the diets. Concentrations of fasting serum insulin and urinary thiobarbituric acid reactive substances were lower in flax oil-fed obese (FO) rats compared with the lard-fed obese (LO) rats (P<0.01). Flax oil feeding also revealed a significant reduction in hepatic TAG and cholesterol concentrations in obese rats compared with the LO rats (P<0.05). In addition, FO rats exhibited significantly higher hepatic mRNA expression of PPAR-gamma, which negatively correlated (r -0.98, P<0.05) with their hepatic lipid levels. These findings suggest that flax oil feeding may activate PPAR-gamma-dependent pathways to alter the hepatic lipid metabolism and to increase insulin sensitivity in the obese SHR/NDmcr-cp rats.
C1 [Chechi, Kanta; Cheema, Sukhinder K.] Mem Univ Newfoundland, Dept Biochem, St John, NF A1B 3X9, Canada.
   [Chechi, Kanta; Yasui, Naomi; Ikeda, Katsumi] Mukogawa Womens Univ, Sch Pharm & Pharmaceut Sci, Dept Pharm, Nishinomiya, Hyogo 6638179, Japan.
   [Yamori, Yukio] Mukogawa Womens Univ, Inst World Hlth Dev, Nishinomiya, Hyogo 6638558, Japan.
C3 Memorial University Newfoundland; Mukogawa Women's University; Mukogawa
   Women's University
RP Cheema, SK (corresponding author), Mem Univ Newfoundland, Dept Biochem, St John, NF A1B 3X9, Canada.
EM skaur@mun.ca
OI Chechi, Kanta/0000-0003-1929-4128
FU Mukogawa Women's University, Hyogo, Japan; Japanese Society for the
   Promotion of Science (JSPS); Matsumae International Foundation (MIF),
   Tokyo, Japan; Natural Sciences and Engineering Research Council of
   Canada; Canadian Innovation Fund
FX This work was supported by the Open Research Center Project of Mukogawa
   Women's University, Hyogo, Japan; the Japanese Society for the Promotion
   of Science (JSPS), Matsumae International Foundation (MIF), Tokyo,
   Japan; and the Natural Sciences and Engineering Research Council of
   Canada and Canadian Innovation Fund. S. K. C. is a JSPS fellow and K. C.
   is a MIF fellow. K. C. was involved in the design of the study,
   execution of the experiments, data analysis and preparation of the
   manuscript; N. Y. helped with the animal feeding and other experiments;
   K. I. and Y. Y. were involved in the conception and execution of the
   study; and S. K. C. was involved in the conception, design and execution
   of the study, along with preparation and revisions of the manuscript.
   The present study represents the original work that has not been
   published previously, and is not presently being considered by another
   journal, and that if accepted for the British Journal of Nutrition, will
   not be published elsewhere in the same form, in English or in any other
   language, without the written consent of the Nutrition Society. All the
   procedures used were approved by the Mukogawa Women's University Animal
   Care Committee. The authors would like to disclose that there are no
   financial or other contractual agreements that might cause conflicts of
   interest or be perceived as causing conflicts of interest.
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NR 49
TC 12
Z9 13
U1 0
U2 7
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1145
EI 1475-2662
J9 BRIT J NUTR
JI Br. J. Nutr.
PD NOV
PY 2010
VL 104
IS 9
BP 1313
EP 1321
DI 10.1017/S0007114510002187
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 677TS
UT WOS:000284015300007
PM 20546645
OA Bronze
DA 2025-06-11
ER

PT J
AU Druss, BG
   Li, JH
   Tapscott, S
   Lally, CA
AF Druss, Benjamin G.
   Li, Jianheng
   Tapscott, Stephanie
   Lally, Cathy A.
TI Randomized Trial of a Mobile Personal Health Record for Behavioral
   Health Homes
SO PSYCHIATRIC SERVICES
LA English
DT Article
ID SERIOUS MENTAL-ILLNESS; MEDICAL-CARE; PATIENT ASSESSMENT;
   SELF-MANAGEMENT; PEOPLE; QUALITY; ADULTS; INTERVENTIONS; VALIDATION;
   SETTINGS
AB Objective: Behavioral health homes, which provide onsite primary medical care in mental health clinics, face challenges in integrating information across multiple health records. This study tested whether a mobile personal health record application improved quality of medical care for individuals treated in these settings.
   Methods: This randomized study enrolled 311 participants with a serious mental illness and one or more cardiometabolic risk factors across two behavioral health homes to receive a mobile personal health record application (N=156) or usual care (N=155). A secure mobile personal health record (mPHR) app provided participants in the intervention group with key information about diagnoses, medications, and laboratory test values and allowed them to track health goals. The primary study outcome was a chart-derived composite measure of quality of cardiometabolic and preventive services.
   Results: At 12-month follow-up, participants in the mPHR group maintained high quality of care (70% of indicated services at baseline and at 12-month follow-up), in contrast to a decline in quality for the usual-care group (71% at baseline and 67% at follow-up), resulting in a statistically significant but clinically modest differential impact between the groups. No differences between the study groups were found in secondary self-reported outcomes, including delivery of chronic illness care, patient activation, and quality of life related to mental or general medical health.
   Conclusions: Use of a mPHR app was associated with a statistically significant but clinically modest differential benefit for quality of medical care among individuals with serious mental illness and comorbid cardiometabolic conditions.
C1 [Druss, Benjamin G.; Li, Jianheng; Tapscott, Stephanie; Lally, Cathy A.] Emory Univ, Rollins Sch Publ Hlth, Dept Hlth Policy & Management, Atlanta, GA 30322 USA.
C3 Emory University; Rollins School Public Health
RP Druss, BG (corresponding author), Emory Univ, Rollins Sch Publ Hlth, Dept Hlth Policy & Management, Atlanta, GA 30322 USA.
EM bdruss@emory.edu
RI Li, Jianheng/MZR-5198-2025
FU National Institute of Mental Health [R01-MH-100467]
FX The study was funded by the National Institute of Mental Health
   (R01-MH-100467). The study sponsor provided financial support only and
   had no role in the analysis and interpretation of the data or in the
   preparation, review, or approval of the manuscript. ClinicalTrials.gov
   registry number: NCT01890226.
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NR 50
TC 10
Z9 10
U1 0
U2 4
PU AMER PSYCHIATRIC PUBLISHING, INC
PI WASHINGTON
PA 800 MAINE AVE SW, SUITE 900, WASHINGTON, DC 20024 USA
SN 1075-2730
EI 1557-9700
J9 PSYCHIAT SERV
JI Psychiatr. Serv.
PD AUG
PY 2020
VL 71
IS 8
BP 803
EP 809
DI 10.1176/appi.ps.201900381
PG 7
WC Health Policy & Services; Public, Environmental & Occupational Health;
   Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services; Public, Environmental & Occupational
   Health; Psychiatry
GA MW1SE
UT WOS:000556825000008
PM 32362226
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Mocan, M
   Anton, F
   Suciu, S
   Rahaian, R
   Blaga, SN
   Farcas, AD
AF Mocan, Mihaela
   Anton, Florin
   Suciu, Soimita
   Rahaian, Rodica
   Blaga, Sorin Nicu
   Farcas, Anca Daniela
TI Multimarker Assessment of Diastolic Dysfunction in Metabolic Syndrome
   Patients
SO METABOLIC SYNDROME AND RELATED DISORDERS
LA English
DT Article
DE metabolic syndrome; left ventricular diastolic dysfunction;
   inflammation; oxidative stress; NT-proBNP
ID C-REACTIVE PROTEIN; NATRIURETIC PEPTIDE; MYOCARDIAL FIBROSIS; CONSENSUS
   STATEMENT; EJECTION FRACTION; HEART-FAILURE; INTERLEUKIN-6; PREVENTION;
   PARAMETERS; SOCIETY
AB Background: Metabolic syndrome (MetS) has been associated with left ventricular diastolic dysfunction (LVDD) with preserved systolic function. This study aims at identifying the predictive factors for LVDD in MetS patients. Methods: The studied group comprised 72 consecutive hospitalized patients (2010-2011) diagnosed with MetS based on AHA/NHLBI/IDF 2009 definition, free of cardiovascular disease (36.11% males, age 59.195.26 years), who underwent echocardiographic examination. Laboratory measurements of high-sensitivity C-reactive protein (hs-CRP), fibrinogen (Fbg) and interleukin-6 (IL-6), 8-isoprostaglandin-F2alpa (8-isoPGF2), uric acid, glutathione peroxidases, and N-terminal pro-B-type natriuretic peptide (NT-proBNP) were measured. Results: LVDD was identified in 47 (65.27%) of the MetS patients. The diastolic blood pressure (DBP) was the strongest prediction factor for LVDD (areas under the receiver operating curve [AUC]: 0.73, odds ratios [OR]: 1.065). The number of MetS criteria was also significantly predictive for LVDD (AUC: 0.65, OR: 2.029, P<0.04). IL-6, hs-CRP, Fbg, and NT-proBNP were predictive for LVDD when receiver operating curve (ROC) analyses were used. The multimarker model comprising age, sex, SBP and DBP, waist, circumference, triglycerides along with hs-CRP, IL-6, and NT-proBNP had the best predictive capacity (AUC: 0.88, P=0.0001). In multivariate analysis, IL-6 remained an independent predictive biomarker for LVDD (OR: 2.045). Conclusion: Both MetS components and biomarkers of inflammation (IF) are predictive factors for LVDD. The best predictive multimarker model for LVDD in MetS patients is composed of waist, triglycerides (TGL), SBP, DBP, fasting glucose, IL-6, hs-CRP, and NT-proBNP. IL-6 remains an independent predictive biomarker for LVDD in MetS patients, underlining the importance of IF in the evolution of MetS to subclinical cardiac damage.
C1 [Mocan, Mihaela; Anton, Florin; Blaga, Sorin Nicu; Farcas, Anca Daniela] Univ Med & Pharm Iuliu Hatieganu Cluj Napoca, Dept Internal Med, 8 Victor Babes, Cluj Napoca 400012, Romania.
   [Mocan, Mihaela; Blaga, Sorin Nicu] Emergency Cty Hosp Cluj, Div Internal Med, Cluj Napoca, Romania.
   [Anton, Florin; Farcas, Anca Daniela] Emergency Cty Hosp Cluj, Div Cardiol, Cluj Napoca, Romania.
   [Suciu, Soimita] Univ Med & Pharm Iuliu Hatieganu Cluj Napoca, Dept Physiol, Cluj Napoca, Romania.
   [Rahaian, Rodica] Emergency Cty Hosp Cluj, Div Immunol, Cluj Napoca, Romania.
C3 Iuliu Hatieganu University of Medicine & Pharmacy; Iuliu Hatieganu
   University of Medicine & Pharmacy
RP Mocan, M (corresponding author), Univ Med & Pharm Iuliu Hatieganu Cluj Napoca, Dept Internal Med, 8 Victor Babes, Cluj Napoca 400012, Romania.
EM mihaela.mocan@gmail.com
RI Farcas, Anca/O-7569-2014; Mocan, Mihaela/L-4813-2019; Suciu,
   Şoimiţa/S-8470-2017
OI Mocan, Mihaela/0000-0001-5906-8024; Suciu, Soimita
   Mihaela/0000-0003-2208-5132
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NR 34
TC 16
Z9 16
U1 1
U2 4
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-4196
EI 1557-8518
J9 METAB SYNDR RELAT D
JI Metab. Syndr. Relat. Disord.
PD DEC
PY 2017
VL 15
IS 10
BP 507
EP 514
AR 0060
DI 10.1089/met.2017.0060
EA NOV 2017
PG 8
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA FP5BZ
UT WOS:000414580500001
PM 29099655
DA 2025-06-11
ER

PT J
AU Waniek, S
   di Giuseppe, R
   Plachta-Danielzik, S
   Ratjen, I
   Jacobs, G
   Koch, M
   Borggrefe, J
   Both, M
   Müller, HP
   Kassubek, J
   Nöthlings, U
   Esatbeyoglu, T
   Schlesinger, S
   Rimbach, G
   Lieb, W
AF Waniek, Sabina
   di Giuseppe, Romina
   Plachta-Danielzik, Sandra
   Ratjen, Ilka
   Jacobs, Gunnar
   Koch, Manja
   Borggrefe, Jan
   Both, Marcus
   Mueller, Hans-Peter
   Kassubek, Jan
   Noethlings, Ute
   Esatbeyoglu, Tuba
   Schlesinger, Sabrina
   Rimbach, Gerald
   Lieb, Wolfgang
TI Association of Vitamin E Levels with Metabolic Syndrome, and MRI-Derived
   Body Fat Volumes and Liver Fat Content
SO NUTRIENTS
LA English
DT Article
DE vitamin E; alpha- and gamma-tocopherol; metabolic syndrome; body fat
   volumes; liver fat content
ID TOCOPHEROL TRANSFER PROTEIN; ALPHA-TOCOPHEROL; OXIDATIVE STRESS;
   NONALCOHOLIC STEATOHEPATITIS; ANTIOXIDANT CONCENTRATIONS; SERUM
   CONCENTRATIONS; ADIPOSE-TISSUE; BETA-CAROTENE; PLASMA-LEVELS;
   DOUBLE-BLIND
AB We aimed to relate circulating alpha- and gamma-tocopherol levels to a broad spectrum of adiposity-related traits in a cross-sectional Northern German study. Anthropometric measures were obtained, and adipose tissue volumes and liver fat were quantified by magnetic resonance imaging in 641 individuals (mean age 61 years; 40.6% women). Concentrations of alpha- and gamma-tocopherol were measured using high performance liquid chromatography. Multivariable-adjusted linear and logistic regression were used to assess associations of circulating alpha- and gamma-tocopherol/cholesterol ratio levels with visceral (VAT) and subcutaneous adipose tissue (SAT), liver signal intensity (LSI), fatty liver disease (FLD), metabolic syndrome (MetS), and its individual components. The gamma-tocopherol/cholesterol ratio was positively associated with VAT (scaled by interquartile range (IQR): 0.036; 95%Confidence Interval (CI): 0.0003; 0.071) and MetS (Odds Ratio (OR): 1.83; 95% CI: 1.21-2.76 for 3rd vs. 1st tertile), and the gamma-tocopherol/cholesterol ratio was positively associated with VAT ( scaled by IQR: 0.066; 95% CI: 0.027; 0.104), SAT ( scaled by IQR: 0.048; 95% CI: 0.010; 0.087) and MetS (OR: 1.87; 95% CI: 1.23-2.84 for 3rd vs. 1st tertile). alpha- and gamma-tocopherol levels were positively associated with high triglycerides and low high density lipoprotein cholesterol levels (all P-trend < 0.05). No association of alpha- and gamma-tocopherol/cholesterol ratio with LSI/FLD was observed. Circulating vitamin E levels displayed strong associations with VAT and MetS. These observations lay the ground for further investigation in longitudinal studies.
C1 [Waniek, Sabina; di Giuseppe, Romina; Plachta-Danielzik, Sandra; Ratjen, Ilka; Jacobs, Gunnar; Koch, Manja; Lieb, Wolfgang] Christian Albrechts Univ Kiel, Inst Epidemiol, D-24105 Kiel, Germany.
   [Jacobs, Gunnar; Lieb, Wolfgang] Univ Hosp Schleswig Holstein, Biobank PopGen, Campus Kiel, D-24105 Kiel, Germany.
   [Koch, Manja] Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA.
   [Borggrefe, Jan] Univ Hosp Cologne, Inst Diagnost & Intervent Radiol, D-50937 Cologne, Germany.
   [Both, Marcus] Univ Hosp Schleswig Holstein, Dept Radiol & Neuroradiol, Campus Kiel, D-24105 Kiel, Germany.
   [Mueller, Hans-Peter; Kassubek, Jan] Univ Ulm, Dept Neurol, D-89081 Ulm, Germany.
   [Noethlings, Ute] Univ Bonn, Dept Nutr & Food Sci, D-53113 Bonn, Germany.
   [Esatbeyoglu, Tuba; Rimbach, Gerald] Christian Albrechts Univ Kiel, Inst Human Nutr & Food Sci, D-24118 Kiel, Germany.
   [Schlesinger, Sabrina] Heinrich Heine Univ Dusseldorf, German Diabet Ctr DDZ, Inst Biometr & Epidemiol, D-40225 Dusseldorf, Germany.
C3 University of Kiel; University of Kiel; Schleswig Holstein University
   Hospital; Harvard University; Harvard T.H. Chan School of Public Health;
   University of Cologne; University of Kiel; Schleswig Holstein University
   Hospital; Ulm University; University of Bonn; University of Kiel;
   Heinrich Heine University Dusseldorf; Leibniz Association; Deutsches
   Diabetes-Zentrum (DDZ)
RP Lieb, W (corresponding author), Christian Albrechts Univ Kiel, Inst Epidemiol, D-24105 Kiel, Germany.; Lieb, W (corresponding author), Univ Hosp Schleswig Holstein, Biobank PopGen, Campus Kiel, D-24105 Kiel, Germany.
EM sabina.waniek@epi.uni-kiel.de; romina.digiuseppe@epi.uni-kiel.de;
   sandra.plachta-danielzik@epi.uni-kiel.de; ilka.ratjen@epi.uni-kiel.de;
   jacobs@popgen.de; mkoch@hsph.harvard.edu; jan.borggrefe@uk-koeln.de;
   Marcus.both@uksh.de; hans-peter.mueller@uni-ulm.de;
   jan.kassubek@uni-ulm.de; noethlings@uni-bonn.de;
   tuba.esatbeyoglu@mri.bund.de;
   sabrina.schlesinger@DDZ.uni-duesseldorf.de; rimbach@foodsci.uni-kiel.de;
   wolfgang.lieb@epi.uni-kiel.de
RI Esatbeyoglu, Tuba/ABB-7997-2021; Borggrefe, Jan/N-6549-2018; Nöthlings,
   Ute/B-2713-2010; Gratten, Jacob/G-1485-2011; Mueller,
   Hans/JYQ-4388-2024; Both, Marcus/F-9633-2010; Lieb,
   Wolfgang/AAC-7650-2022; Rimbach, Gerald/A-7178-2011; Schlesinger,
   Sabrina/AAE-7640-2020; Kassubek, Jan/F-2774-2015
OI Rimbach, Gerald/0000-0001-7888-4684; Schlesinger,
   Sabrina/0000-0003-4244-0832; Esatbeyoglu, Tuba/0000-0003-2413-6925;
   Kassubek, Jan/0000-0002-7106-9270; Waniek, Sabina/0000-0003-4381-9676;
   di Giuseppe, Romina/0000-0002-5214-8897; Nothlings,
   Ute/0000-0002-5789-2252; Borggrefe, Jan/0000-0003-2908-7560; Koch,
   Manja/0000-0002-4794-4821; Both, Marcus/0000-0001-6357-1538
FU German Research Foundation (Deutsche Forschungsgemeinschaft, DFG) [KO
   5187/1-1]; Deutsche Forschungsgemeinschaft Excellence Cluster
   "Inflammation at Interfaces" [EXC306, EXC306/2]; German Federal Ministry
   of Education and Research [01GR0468, 01EY1103]
FX Manja Koch is recipient of a Postdoctoral Research Fellowship from the
   German Research Foundation (Deutsche Forschungsgemeinschaft, DFG, KO
   5187/1-1). Romina di Giuseppe is supported by the Deutsche
   Forschungsgemeinschaft Excellence Cluster "Inflammation at Interfaces"
   (grants EXC306 and EXC306/2). The PopGen 2.0 Network is supported by the
   German Federal Ministry of Education and Research (grant 01GR0468 and
   01EY1103). The founding sponsors had no role in the design of the study;
   in the collection, analyses, or interpretation of data; in the writing
   of the manuscript, and in the decision to publish the results.
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NR 51
TC 35
Z9 35
U1 0
U2 7
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 2072-6643
J9 NUTRIENTS
JI Nutrients
PD OCT
PY 2017
VL 9
IS 10
AR 1143
DI 10.3390/nu9101143
PG 15
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA FM0DM
UT WOS:000414629900099
PM 29057829
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU McElroy, SL
   Frye, MA
   Hellemann, G
   Altshuler, L
   Leverich, GS
   Suppes, T
   Keck, PE
   Nolen, WA
   Kupka, R
   Post, RM
AF McElroy, Susan L.
   Frye, Mark A.
   Hellemann, Gerhard
   Altshuler, Lori
   Leverich, Gabriele S.
   Suppes, Trisha
   Keck, Paul E.
   Nolen, Willem A.
   Kupka, Ralph
   Post, Robert M.
TI Prevalence and correlates of eating disorders in 875 patients with
   bipolar disorder
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Eating disorders; Bipolar disorder; Binge
ID COMORBIDITY SURVEY REPLICATION; TREATMENT ENHANCEMENT PROGRAM;
   ANOREXIA-NERVOSA; STEP-BD; PSYCHIATRIC-DISORDERS; METABOLIC SYNDROME;
   CO-MORBIDITY; I-DISORDER; SPECTRUM; ILLNESS
AB Objective: Relatively little is known about the co-occurrence of bipolar and eating disorders. We therefore assessed the prevalence and clinical correlates of eating disorders in 875 patients with bipolar disorder.
   Method: 875 outpatients with DSM-IV bipolar I or II disorder were evaluated with structured diagnostic interviews and clinician- and self-administered questionnaires to determine bipolar and eating disorder diagnoses, other comorbid Axis I disorder diagnoses, and demographic and historical illness characteristics.
   Results: 125 (14.3%) patients met DSM-IV criteria for at least one comorbid lifetime Axis I eating disorder, with binge eating disorder (N = 77) being more common than bulimia nervosa (n = 42) and anorexia nervosa (N = 27). There were no significant eating disorder comorbidity differences between bipolar I and bipolar II patients. Presence of a lifetime comorbid eating disorder was associated with female gender, younger age, earlier age of onset of mood symptoms and of bipolar disorder, presentation in a mixed episode, greater number of prior mood episodes, history of rapid cycling and suicide attempts, greater mean BMI, obesity and severe obesity, and family history of depression, bipolar disorder, alcoholism, and drug abuse. When the three eating disorder groups were compared, lifetime anorexia nervosa was associated with normal weight and a lifetime anxiety disorder, lifetime bulimia nervosa was associated with overweight, and lifetime binge eating disorder was associated with obesity and severe obesity.
   Conclusions: Patients with bipolar disorder, especially women, not infrequently have comorbid eating disorders, and this comorbidity is associated with an earlier age of onset and more severe course of bipolar illness. (C) 2010 Elsevier B.V. All rights reserved.
C1 [McElroy, Susan L.; Keck, Paul E.] Craig & Frances Lindner Ctr HOPE, Mason, OH USA.
   [McElroy, Susan L.; Keck, Paul E.] Univ Cincinnati, Coll Med, Dept Psychiat, Cincinnati, OH USA.
   [Frye, Mark A.] Mayo Clin, Dept Psychiat & Psychol, Rochester, MN USA.
   [Hellemann, Gerhard; Altshuler, Lori] Univ Calif Los Angeles, Dept Psychiat & Behav Sci, Los Angeles, CA 90024 USA.
   [Altshuler, Lori] VA Greater Los Angeles Healthcare Syst, W Los Angeles Healthcare Ctr, Dept Psychiat, Los Angeles, CA USA.
   [Leverich, Gabriele S.; Post, Robert M.] Bipolar Collaborat Network, Bethesda, MD USA.
   [Suppes, Trisha] Stanford Univ, Sch Med, Dept Psychiat & Behav Sci, Palo Alto, CA 94304 USA.
   [Suppes, Trisha] VA Palo Alto Hlth Care Syst, Bipolar Disorder Res Program, Palo Alto, CA USA.
   [Nolen, Willem A.] Univ Groningen, Dept Psychiat, Univ Med Ctr Groningen, Groningen, Netherlands.
   [Kupka, Ralph] Altrech Inst Mental Hlth Care, Utrecht, Netherlands.
   [Post, Robert M.] George Washington Sch Med, Washington, DC USA.
C3 University System of Ohio; University of Cincinnati; Mayo Clinic;
   University of California System; University of California Los Angeles;
   US Department of Veterans Affairs; Veterans Health Administration (VHA);
   VA Greater Los Angeles Healthcare System; Stanford University; US
   Department of Veterans Affairs; Veterans Health Administration (VHA); VA
   Palo Alto Health Care System; University of Groningen; George Washington
   University
RP McElroy, SL (corresponding author), Linder Ctr HOPE, 4075 Old Western Row Rd, Mason, OH 45040 USA.
EM susan.mcelroy@lindnercenter.org
RI Kupka, Ralph/HDM-4184-2022; Nolen, Willem/E-9006-2014
OI Kupka, Ralph/0000-0002-1662-7436
FU Astra Zeneca Pharmaceuticals; National Institute of Mental Health
   (NIMH); Pfizer; Pharma Solutions (CNS Drug Supplement); Wolters Kluwer;
   Theodore and Vada Stanley Foundation
FX T Suppes receives honoraria and/or research support from Astra Zeneca
   Pharmaceuticals, National Institute of Mental Health (NIMH), Pfizer,
   Pharma Solutions (CNS Drug Supplement), and Wolters Kluwer.Supported by
   a generous grant from The Theodore and Vada Stanley Foundation.
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NR 49
TC 125
Z9 133
U1 1
U2 30
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0165-0327
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD FEB
PY 2011
VL 128
IS 3
BP 191
EP 198
DI 10.1016/j.jad.2010.06.037
PG 8
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA 743JG
UT WOS:000289014000002
PM 20674033
DA 2025-06-11
ER

PT J
AU Lee, S
AF Lee, Sunghou
TI Aequorin Based Functional Assessment of the Melanin Concentrating
   Hormone Receptor by Intracellular Calcium Mobilization
SO BIOMOLECULES & THERAPEUTICS
LA English
DT Article
DE Melanin concentrating hormone; MCH1; Aequorin; High throughput
   screening; Calcium mobilization
ID PROTEIN-COUPLED RECEPTOR; INDUCED OBESE MICE; ANTAGONIST;
   IDENTIFICATION; DEPRESSION; ANXIETY; SLC-1; ASSAY; RESPONSES; LIGAND
AB Melanin concentrating hormone is a neuropeptide highly expressed in the brain that regulates several physiological functions mediated by receptors in the G-protein coupled receptor family, especially plays an important role in the complex regulation of energy balance and body weight mediated by the melanin concentrating hormone receptor subtype 1 (MCH1). Compelling pharmacological evidence implicating MCH1 signaling in the regulation of food intake and energy expenditure has generated a great deal of interest by pharmaceutical companies as MCH1 antagonists may have potential therapeutic benefit in the treatment of obesity and metabolic syndrome. Although fluorescence-based calcium mobilization assay platform has been one of the most widely accepted tools for receptor research and drug discovery, fluorescence interference and shallow assay window limit their application in high throughput screening and have led to a growing interest in alternative, luminescence-based technologies. Herein, a luminescence-based functional assay system for the MCH1 receptor was developed and validated with the mitochondrial targeted aequorin. Aequorin based functional assay system for MCH1 presented excellent Z' factor (0.8983) and high signal-to-noise ratio (141.9). The nonpeptide MCH1 receptor antagonist, SNAP 7941 and GSK 803430, exhibited IC(50) values of 0.62 +/- 0.11 and 12.29 +/- 2.31 nM with excellent correlation coefficient. These results suggest that the aequorin based assay system for MCH1 is a strong alternative to the traditional GPCR related tools such as radioligand binding experiments and fluorescence functional determinations for the compound screening and receptor research.
C1 Sangmyung Univ, Dept Biomed Technol, Cheonan 330720, South Korea.
C3 Sangmyung University
RP Lee, S (corresponding author), Sangmyung Univ, Dept Biomed Technol, Cheonan 330720, South Korea.
EM sunghou.lee@gmail.com
FU Center for Biological Modulators [CBM32-B4001-01-01-00]; National
   Research Foundation of Korea [KRF-2008-331-E00019]; Ministry of
   Education, Science and Technology
FX This work was supported by the grants from the Center for Biological
   Modulators of the 21C Frontier R&D Program (CBM32-B4001-01-01-00) and
   from the National Research Foundation of Korea Grant
   (KRF-2008-331-E00019), the Ministry of Education, Science and
   Technology.
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NR 32
TC 0
Z9 0
U1 0
U2 2
PU KOREAN SOC APPLIED PHARMACOLOGY
PI SEOUL
PA RM 805, KOREAN FEDERATION SCIENCE & TECHNOLOGY B/D, 635-4 YEOKSAM-DONG,
   KANGNAM-GU, SEOUL, 135-703, SOUTH KOREA
SN 1976-9148
J9 BIOMOL THER
JI Biomol. Ther.
PD APR 30
PY 2010
VL 18
IS 2
BP 152
EP 158
DI 10.4062/biomolther.2010.18.2.152
PG 7
WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
GA 595AB
UT WOS:000277582000004
OA Bronze
DA 2025-06-11
ER

PT J
AU Aslam, H
   Jacka, FN
   Marx, W
   Karatzi, K
   Mavrogianni, C
   Karaglani, E
   Mohebbi, M
   Pasco, JA
   O'Neil, A
   Berk, M
   Nomikos, T
   Kanellakis, S
   Androutsos, O
   Manios, Y
   Moschonis, G
AF Aslam, Hajara
   Jacka, Felice N.
   Marx, Wolfgang
   Karatzi, Kalliopi
   Mavrogianni, Christina
   Karaglani, Eva
   Mohebbi, Mohammadreza
   Pasco, Julie A.
   O'Neil, Adrienne
   Berk, Michael
   Nomikos, Tzortzis
   Kanellakis, Spyridon
   Androutsos, Odysseas
   Manios, Yannis
   Moschonis, George
TI The Associations between Dairy Product Consumption and Biomarkers of
   Inflammation, Adipocytokines, and Oxidative Stress in Children: A
   Cross-Sectional Study
SO NUTRIENTS
LA English
DT Article
DE milk; dairy products; oxidative stress; inflammation; obesity; leptin;
   children
ID C-REACTIVE PROTEIN; CARDIOMETABOLIC RISK; LEPTIN; WEIGHT; OBESITY;
   PROFILE; YOGURT; IMPACT; ADULTS; ALPHA
AB The association between dairy product consumption and biomarkers of inflammation, adipocytokines, and oxidative stress is poorly studied in children. Therefore, these associations were examined in a representative subsample of 1338 schoolchildren with a mean age of 11.5 (+/- 0.7) years in the Healthy Growth Study. Information on dairy product consumption was collected by dietary recalls. Total dairy consumption was calculated by summing the intake of milk, yogurt, and cheese. Inflammatory markers, i.e., high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), and adipocytokines, i.e., leptin, adiponectin, and the antioxidant enzyme glutathione peroxidase (GPx) were analysed. Due to the skewed distribution hs-CRP, IL-6, and leptin were log transformed. Multivariable regression analyses adjusted for age, sex, energy intake, physical activity, parental education, Tanner stage, and fat mass were used to assess the associations between consumption of total dairy, milk, yogurt, cheese, and markers of inflammation, adipocytokines, oxidative stress, and adiponectin-leptin ratio. Our results showed that milk consumption was inversely associated with leptin (beta: -0.101; 95% CI: -0.177, -0.025, p = 0.009) and positively associated with the adiponectin-leptin ratio (beta: 0.116; 95% CI: 0.020, 0.211; p = 0.018), while total dairy, cheese, and yogurt consumption were not associated with inflammatory, adipocytokine, or antioxidant markers. Further prospective studies are needed to confirm these results.
C1 [Aslam, Hajara; Jacka, Felice N.; Marx, Wolfgang; Pasco, Julie A.; O'Neil, Adrienne; Berk, Michael] Deakin Univ, Barwon Hlth, Sch Med, IMPACT Inst Mental & Phys Hlth & Clin Translat, Geelong, Vic 3220, Australia.
   [Jacka, Felice N.] Murdoch Childrens Res Inst, Ctr Adolescent Hlth, Parkville, Vic 3052, Australia.
   [Jacka, Felice N.] Black Dog Inst, Sydney, NSW 2031, Australia.
   [Jacka, Felice N.] James Cook Univ, Biomed Sci, Douglas, Qld 4811, Australia.
   [Karatzi, Kalliopi; Mavrogianni, Christina; Karaglani, Eva; Nomikos, Tzortzis; Kanellakis, Spyridon; Manios, Yannis] Harokopio Univ, Sch Hlth Sci & Educ, Dept Nutr & Dietet, Athens 17676, Greece.
   [Mohebbi, Mohammadreza] Deakin Univ, Fac Hlth, Biostat Unit, Burwood, Vic 3125, Australia.
   [Pasco, Julie A.] Univ Melbourne, Dept Med Western Hlth, St Albans, Vic 3010, Australia.
   [Pasco, Julie A.] Monash Univ, Dept Epidemiol & Prevent Med, Prahran, Vic 3800, Australia.
   [O'Neil, Adrienne] Univ Melbourne, Melbourne Sch Publ Hlth, Melbourne, Vic 3010, Australia.
   [Berk, Michael] Univ Melbourne, Florey Inst Neurosci & Mental Hlth, Ctr Youth Mental Hlth, Orygen,Natl Ctr Excellence Youth Mental Hlth, Melbourne, Vic 3010, Australia.
   [Berk, Michael] Univ Melbourne, Dept Psychiat, Melbourne, Vic 3010, Australia.
   [Androutsos, Odysseas] Univ Thessaly, Sch Phys Educ Sport Sci & Dietet, Dept Nutr & Dietet, Thessaly 38221, Greece.
   [Moschonis, George] La Trobe Univ, Sch Allied Hlth Human Serv & Sport, Dept Dietet Nutr & Sport, Melbourne, Vic 3086, Australia.
C3 Barwon Health; Deakin University; Murdoch Children's Research Institute;
   Black Dog Institute; James Cook University; Harokopio University Athens;
   Deakin University; University of Melbourne; Monash University;
   University of Melbourne; Florey Institute of Neuroscience & Mental
   Health; Orygen, The National Centre of Excellence in Youth Mental
   Health; University of Melbourne; University of Melbourne; University of
   Thessaly; La Trobe University
RP Manios, Y (corresponding author), Harokopio Univ, Sch Hlth Sci & Educ, Dept Nutr & Dietet, Athens 17676, Greece.; Moschonis, G (corresponding author), La Trobe Univ, Sch Allied Hlth Human Serv & Sport, Dept Dietet Nutr & Sport, Melbourne, Vic 3086, Australia.
EM habdussa@deakin.edu.au; f.jacka@deakin.edu.au; wolf.marx@deakin.edu.au;
   pkaratzi@hua.gr; cmavrog@hua.gr; ekaragl@hua.gr;
   m.mohebbi@deakin.edu.au; julie.pasco@deakin.edu.au;
   adrienne.oneil@deakin.edu.au; michael.berk@deakin.edu.au;
   tnomikos@hua.gr; kanellakis@hua.gr; oandroutsos@uth.gr; manios@hua.gr;
   g.moschonis@latrobe.edu.au
RI Berk, Michael/AGH-9427-2022; Marx, Wolfgang/AFO-7355-2022; Nomikos,
   Tzortzis/AAD-5269-2019; Androutsos, Odysseas/ABF-8670-2021; Jacka,
   Felice/ABE-6322-2020; Manios, Yannis/AAM-8953-2021; Ackland,
   Julie/C-8607-2012; Karatzi, Kalliopi/AGJ-2400-2022; Moschonis,
   George/AAM-9616-2021; Stefanadis, Christodoulos/ABH-2232-2020; Berk,
   Michael/M-7891-2013
OI Aslam, Dr Hajara/0000-0002-6023-1658; Karatzi,
   Kalliopi/0000-0001-5453-898X; Marx, Wolfgang/0000-0002-8556-8230;
   Stefanadis, Christodoulos/0000-0001-5974-6454; Manios,
   Yannis/0000-0001-6486-114X; Berk, Michael/0000-0002-5554-6946;
   Mavrogianni, Christina/0000-0002-3534-6832; Moschonis,
   George/0000-0003-3009-6675; O'Neil, Adrienne/0000-0002-4811-5830;
   Karaglani, Eva/0000-0001-5395-7023; Pasco, Julie/0000-0002-8968-4714
FU Deakin University Postgraduate Industry Research Scholarship; Brain and
   Behaviour Research Institute; National Health and Medical Research
   Council (NHMRC); Geelong Medical Research Foundation; Ian Potter
   Foundation; University of Melbourne; Fernwood Foundation; Wilson
   Foundation; JTM Foundation; Serp Hills Foundation; Roberts Family
   Foundation; Waterloo Foundation; NHMRC Senior Principal Research
   Fellowship [1059660, 1156072]; NIH; Simons Autism Foundation; Cancer
   Council of Victoria; Stanley Medical Research Foundation; Medical
   Benefits Fund; National Health and Medical Research Council; Medical
   Research Futures Fund; Beyond Blue; Rotary Health; A2 milk company; Meat
   and Livestock Board; Woolworths; Avant; HarryWindsor Foundation; Heart
   Foundation Australia [101160]; National Health & Medical Research
   Council; Australian Research Council; Deakin University; Sanofi; Meat
   and Livestock Australia; Woolworths Limited; Be Fit Foods; Australian
   Rotary Health; Sanofi-Synthelabo; Janssen Cilag; Servier; Pfizer; Health
   Ed; Network Nutrition; Angelini Farmaceutica; Eli Lilly; Metagenics
FX H.A. is supported by Deakin University Postgraduate Industry Research
   Scholarship. F.N.J. has received: (1) competitive Grant/Research support
   from the Brain and Behaviour Research Institute, the National Health and
   Medical Research Council (NHMRC), Australian Rotary Health, the Geelong
   Medical Research Foundation, the Ian Potter Foundation, The University
   of Melbourne; (2) industry support for research from Meat and Livestock
   Australia, Woolworths Limited, the A2 Milk Company, Be Fit Foods; (3)
   philanthropic support from the Fernwood Foundation, Wilson Foundation,
   the JTM Foundation, the Serp Hills Foundation, the Roberts Family
   Foundation, theWaterloo Foundation; and (4) travel support and speakers
   honoraria from Sanofi-Synthelabo, Janssen Cilag, Servier, Pfizer, Health
   Ed, Network Nutrition, Angelini Farmaceutica, Eli Lilly, and Metagenics.
   F.N.J. has written two books for commercial publication. M.B. is
   supported by a NHMRC Senior Principal Research Fellowship (1059660 and
   1156072). M.B. has received Grant/Research Support from the NIH,
   Cooperative Research Centre, Simons Autism Foundation, Cancer Council of
   Victoria, Stanley Medical Research Foundation, Medical Benefits Fund,
   National Health and Medical Research Council, Medical Research Futures
   Fund, Beyond Blue, Rotary Health, A2 milk company, Meat and Livestock
   Board, Woolworths, Avant and the HarryWindsor Foundation, has been a
   speaker for Astra Zeneca, Lundbeck, Merck, Pfizer, and served as a
   consultant to Allergan, Astra Zeneca, Bioadvantex, Bionomics,
   Collaborative Medicinal Development, Lundbeck Merck, Pfizer, and
   Servier. A.O. is supported by a Future Leader Fellowship (#101160) from
   the Heart Foundation Australia and Wilson Foundation. She has received
   research funding from the National Health & Medical Research Council,
   Australian Research Council, University of Melbourne, Deakin University,
   Sanofi, Meat and Livestock Australia and Woolworths Limited and
   Honoraria from Novartis. The funding and their sources are unrelated to
   the present study.
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NR 43
TC 5
Z9 5
U1 0
U2 7
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD OCT
PY 2020
VL 12
IS 10
AR 3055
DI 10.3390/nu12103055
PG 15
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA OH8RI
UT WOS:000582858500001
PM 33036196
OA Green Accepted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Kaya, C
   Cengiz, H
   Alay, I
   Örs, S
   Kaya, SE
   Ekin, M
   Yasar, L
AF Kaya, Cihan
   Cengiz, Huseyin
   Alay, Ismail
   Ors, Suna
   Kaya, Sinem Ertas
   Ekin, Murat
   Yasar, Levent
TI The Relation Between Metabolic Syndrome and Its Components with Breast
   Density in Postmenopausal Women
SO METABOLIC SYNDROME AND RELATED DISORDERS
LA English
DT Article
DE breast; mammography; menopause; metabolic syndrome; postmenopause
ID MAMMOGRAPHIC DENSITY; LIPOPROTEIN CHOLESTEROL; OXIDATIVE STRESS; CANCER;
   RISK; ASSOCIATION; GLUCOSE
AB Background: Metabolic syndrome (MetS) could lead to an increase in fatty tissue that could be seen as a radiolucent image depicting breast density (BD) by a mammogram. We aimed to investigate the association between MetS and its separate components with BD among naturally postmenopausal women. Materials and Methods: Data of 494 postmenopausal patients who were admitted to our outpatient clinic between December 2012 and July 2015 were retrospectively reviewed. A total of 279 patients were in the without MetS group and 215 patients were in the with MetS group. Average BD percentage of the left and right breasts were measured. Basic characteristics, laboratory, and mammography results between the without MetS and the with MetS groups were compared. Results: The mean age of the patients was 53.20 +/- 6.67 years in the without MetS group and 55.41 +/- 6.56 years in the with MetS group. There were 219 (78.5%) patients in the without MetS group and 187 (86.9%) patients in the with MetS group with lower BD. The without MetS group had significantly higher BD scores than those patients in the with MetS group (P = 0.02). In correlation analysis, there was a negative correlation between fasting plasma glucose (FPG), systolic and diastolic blood pressures, waist circumference (WC), and BD scores. However, there was a positive correlation between high-density lipoprotein (HDL) and BD score (P = 0.046). In multivariate logistic regression analysis, it is found that lower body mass index (BMI) and parity were significantly associated with higher BD (P = 0.002 and P = 0.001; respectively). Conclusion: The lower BMI and parity may be associated with higher BD in postmenopausal women. In addition, higher HDL and lower FPG, blood pressure, triglyceride, and WC may be correlated with higher BD.
C1 [Kaya, Cihan; Cengiz, Huseyin; Alay, Ismail; Ekin, Murat; Yasar, Levent] Univ Hlth Sci, Dept Obstet & Gynecol, Bakirkoy Dr Sadi Konuk Training & Res Hosp, Tevfik Saglam St,11, TR-34147 Istanbul, Turkey.
   [Ors, Suna] Univ Hlth Sci, Dept Radiol, Van Training & Res Hosp, Van, Turkey.
   [Kaya, Sinem Ertas] VKV Amer Hosp, Dept Obstet & Gynecol, Istanbul, Turkey.
C3 Bakirkoy Dr. Sadi Konuk Research & Training Hospital; Van Training &
   Research Hospital; University of Health Sciences Turkey; Amerikan
   Hospital
RP Alay, I (corresponding author), Univ Hlth Sci, Dept Obstet & Gynecol, Bakirkoy Dr Sadi Konuk Training & Res Hosp, Tevfik Saglam St,11, TR-34147 Istanbul, Turkey.
EM dr_ismailalay@hotmail.com
RI EKİN, MURAT/G-4282-2013; Yasar, Levent/AAL-2513-2020; Cengiz,
   Hüseyin/AAF-4187-2019; Alay, Ismail/ABB-7376-2020; Kaya,
   Cihan/F-8883-2013
OI Kaya, Cihan/0000-0003-4175-7694; ekin, murat/0000-0002-4525-5125
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NR 24
TC 5
Z9 6
U1 0
U2 2
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-4196
EI 1557-8518
J9 METAB SYNDR RELAT D
JI Metab. Syndr. Relat. Disord.
PD AUG 1
PY 2019
VL 17
IS 6
BP 341
EP 345
DI 10.1089/met.2018.0139
EA MAY 2019
PG 5
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA IN5TF
UT WOS:000467441400001
PM 31045476
DA 2025-06-11
ER

PT J
AU Dweik, H
   Kaur, J
   Jaka, S
   Faruki, F
   Shah, RP
   Williams, OCA
   Chalia, A
   Bachu, A
AF Dweik, Hadeel
   Kaur, Jaskaranpreet
   Jaka, Sanobar
   Faruki, Farzana
   Shah, Rushi P.
   Williams, Ozge C. Amuk
   Chalia, Ankit
   Bachu, Anil
TI Cardiometabolic Comorbidity Risk in Pediatric Patients With Psychiatric
   Illnesses: A Case-Control Inpatient Study
SO CUREUS JOURNAL OF MEDICAL SCIENCE
LA English
DT Article
DE risk-factors; cardiometabolic conditions; child and adolescent; obesity
   and diabetes; psychiatric comorbidities
ID METABOLIC SYNDROME; BLOOD-PRESSURE; CHILDREN; OBESITY; ADOLESCENTS;
   DEPRESSION; PREVALENCE; DISORDERS; HEALTH; TRENDS
AB Objectives
   To delineate the differences in the cardiometabolic comorbidities in pediatric patients with medical versus psychiatric illnesses and to determine the risk of association between the spectrum of cardiometabolic comorbidities in pediatric patients with a broad range of psychiatric illnesses.
   Methods
   We conducted a case-control study using the nationwide inpatient sample (NIS), the largest hospital database in the United States (US) and included 179,550 pediatric patients (age 10-18 years) that were hospitalized with a primary diagnosis of psychiatric illness (N = 89,775) and pediatric patients that were hospitalized with a primary diagnosis of medical illness (N = 89,775). We used descriptive statistics and Pearson's chi-square test to delineate the differences between pediatric inpatients with medical versus psychiatric illnesses.
   Results
   The majority of pediatric patients with psychiatric illnesses were females (58%) and white (62%), with a mean age of 15 years. Cardiometabolic comorbidities were higher in patients admitted for psychiatric illness, with a higher prevalence of hypothyroidism (1.6%) and obesity (7.1%) than in those hospitalized for medical illnesses. Among all cardiometabolic comorbidities, obesity had the highest prevalence across all psychiatric illnesses, measuring eight percent in patients with disruptive behavior disorders, followed by seven percent each in anxiety, mood, and psychotic disorders. Diabetes had the lowest prevalence hovering between one and two percent for a spectrum of psychiatric illnesses.
   Conclusion
   The prevalence of cardiometabolic comorbidities is higher in pediatric inpatients with psychiatric illnesses. This calls for timely monitoring of the routine labs and early diagnosis and management of the cardiometabolic comorbidities in this at-risk population.
C1 [Dweik, Hadeel] Univ Jordan, Med, Amman, Jordan.
   [Kaur, Jaskaranpreet] North Alabama Med Ctr, Internal Med, Florence, SC USA.
   [Jaka, Sanobar] NYU, Sch Global Publ Hlth, New York, NY 10012 USA.
   [Faruki, Farzana] Essen Hlth Care, Psychiat, Bronx, NY USA.
   [Shah, Rushi P.] Byramjee Jeejeebhoy Med Coll, Med, Ahmadabad, Gujarat, India.
   [Williams, Ozge C. Amuk] Griffin Mem Hosp, Psychiat, Norman, OK USA.
   [Chalia, Ankit] West Virginia Univ, Sch Med, Behav Med & Psychiat, Martinsburg, WV USA.
   [Bachu, Anil] Univ Arkansas Med Sci, Psychiat, North Little Rock, AR USA.
C3 University of Jordan; New York University; University of Arkansas
   System; University of Arkansas Medical Sciences
RP Jaka, S (corresponding author), NYU, Sch Global Publ Hlth, New York, NY 10012 USA.
EM jsanobar@gmail.com
RI Chalia, Ankit/KHU-2246-2024; Amuk Williams, Ozge/ITU-9689-2023; Bachu,
   Anil/GPG-1540-2022
OI Bachu, Anil/0000-0002-9256-6823
CR Abosi O, 2018, HORM MOL BIOL CLIN I, V36, DOI 10.1515/hmbci-2017-0065
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NR 27
TC 0
Z9 0
U1 0
U2 1
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
EI 2168-8184
J9 CUREUS J MED SCIENCE
JI Cureus J Med Sci
PD JUN 25
PY 2022
VL 14
IS 6
AR e26326
DI 10.7759/cureus.26326
PG 5
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA 3N7JM
UT WOS:000836321900006
PM 35911267
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Luiro, K
   Aittomäki, K
   Jousilahti, P
   Tapanainen, JS
AF Luiro, Kaisu
   Aittomaki, Kristiina
   Jousilahti, Pekka
   Tapanainen, Juha S.
TI Long-term health of women with genetic POI due to FSH-resistant ovaries
SO ENDOCRINE CONNECTIONS
LA English
DT Article
DE POI; primary ovarian insufficiency; primary amenorrhea; FSH receptor;
   osteopenia
ID CAUSE-SPECIFIC MORTALITY; BONE-MINERAL DENSITY; SEXUAL FUNCTION;
   YOUNG-WOMEN; EARLY MENOPAUSE; RISK-FACTORS; HORMONE; INSUFFICIENCY;
   POPULATION; FRACTURES
AB Objective: To study the use of hormone therapy (HT), morbidity and reproductive outcomes of women with primary ovarian insufficiency (POI) due to FSH-resistant ovaries (FSHRO).
   Design: A prospective follow-up study in a university-based tertiary clinic setting.
   Methods: Twenty-six women with an inactivating A189V FSH receptor mutation were investigated by means of a health questionnaire and clinical examination. Twenty-two returned the health questionnaire and 14 were clinically examined. Main outcome measures in the health questionnaire were reported as HT, morbidity, medication and infertility treatment outcomes. In the clinical study, risk factors for cardiovascular disease (CVD) and metabolic syndrome (MetS) were compared to age-matched controls from a national population survey (FINRISK). Average number of controls was 326 per FSHRO subject (range 178-430). Bone mineral density and whole-body composition were analyzed with DXA. Psychological and sexual well-being was assessed with Beck Depression Inventory (BDI21), Generalized Anxiety Disorder 7 (GAD-7) and Female Sexual Function Index (FSFI) questionnaires.
   Results: HT was initiated late (median 18 years of age) compared with normal puberty and the median time of use was shorter (20-22 years) than the normal fertile period. Osteopenia was detected in 9/14 of the FSHRO women despite HT. No major risk factors for CVD or diabetes were found.
   Conclusions: HT of 20 years seems to be associated with a similar cardiovascular and metabolic risk factor profile as in the population control group. However, optimal bone health may require an early-onset and longer period of HT, which would better correspond to the natural fertile period.
C1 [Luiro, Kaisu; Tapanainen, Juha S.] Helsinki Univ Hosp, Dept Obstet & Gynecol, Reprod Med Unit, Helsinki, Finland.
   [Luiro, Kaisu; Tapanainen, Juha S.] Univ Helsinki, Helsinki, Finland.
   [Aittomaki, Kristiina] Helsinki Univ Hosp, Dept Med Genet, Helsinki, Finland.
   [Jousilahti, Pekka] Natl Inst Hlth & Welf, Dept Publ Hlth Solut, Helsinki, Finland.
   [Tapanainen, Juha S.] Univ Oulu, Dept Obstet & Gynecol, Oulu, Finland.
   [Tapanainen, Juha S.] Oulu Univ Hosp, Med Res Ctr, PEDEGO Res Unit, Oulu, Finland.
C3 University of Helsinki; Helsinki University Central Hospital; University
   of Helsinki; University of Helsinki; Helsinki University Central
   Hospital; Finland National Institute for Health & Welfare; University of
   Oulu; University of Oulu
RP Tapanainen, JS (corresponding author), Helsinki Univ Hosp, Dept Obstet & Gynecol, Reprod Med Unit, Helsinki, Finland.; Tapanainen, JS (corresponding author), Univ Helsinki, Helsinki, Finland.
EM juha.tapanainen@helsinki.fi
RI Luiro, Kaisu/LGY-1961-2024
OI Luiro, Kaisu/0000-0003-0736-2891
FU Finnish Medical Society; Sigrid Juselius Foundation; Academy of Finland;
   Helsinki University Hospital; Finska Lakaresallskapet Fund
FX This work was financially supported by the Finnish Medical Society (K
   L), The Sigrid Juselius Foundation (J S T), the Academy of Finland (J S
   T), the Helsinki University Hospital Research Fund (K L, J S T) and
   Finska Lakaresallskapet Fund (K A).
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NR 37
TC 3
Z9 4
U1 0
U2 4
PU BIOSCIENTIFICA LTD
PI BRISTOL
PA EURO HOUSE, 22 APEX COURT WOODLANDS, BRADLEY STOKE, BRISTOL BS32 4JT,
   ENGLAND
SN 2049-3614
J9 ENDOCR CONNECT
JI Endocr. Connect.
PD OCT
PY 2019
VL 8
IS 10
BP 1354
EP 1362
DI 10.1530/EC-19-0244
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA JC5QD
UT WOS:000489337100004
PM 31505457
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Ramezankhani, A
   Tohidi, M
   Hadaegh, F
AF Ramezankhani, Azra
   Tohidi, Maryam
   Hadaegh, Farzad
TI Association between the systemic immune-inflammation index and metabolic
   syndrome and its components: results from the multi-ethnic study of
   atherosclerosis (MESA)
SO CARDIOVASCULAR DIABETOLOGY
LA English
DT Article
DE MESA; Systemic immune-inflammation index; Metabolic syndrome
ID PROGNOSTIC VALUE; RESPONSE INDEX; HYPERTENSION; OBESITY; STRESS; ADULTS
AB Background The Systemic Immune-Inflammation Index (SII) is a novel biomarker of systemic inflammation. We explored the association between the SII and metabolic syndrome (MetS) and its components in middle-aged and older adults. MethodsWe included 2755 participants (1305 men) aged 45-84 years from the Multi-Ethnic Study of Atherosclerosis (MESA) cohort from examination 5 (2010-2012). Logistic regression was employed to assess the relationship between the SII and MetS, as well as its components. Results A total of 1082 participants (463 men) were diagnosed with MetS. On a continuous scale, the SII was positively associated with MetS (odds ratio (OR): 1.23, 95% confidence interval (CI): 1.05-1.46) and its components including hyperglycemia (1.23: 1.05-1.44) and elevated blood pressure (BP) (1.47: 1.14-1.89). When analyzed on a quartile scale, participants in the quartile 4 of SII had 32% and 63% higher prevalence of hyperglycemia and elevated BP, respectively, compared to those in the quartile 1 (P for trend: 0.021 and < 0.001, respectively). Additionally, we identified 40% higher prevalence of low HDL-C in quartile 2 of the SII compared to quartile 1 (1.40; 1.07-1.83) (P trend = 0.454). In subgroup analysis, general obesity status modified the relationship between SII and abdominal obesity, showing a positive association in obese individuals (1.72: 1.00-2.95) and a negative association (0.80: 0.66-0.97) in non-obese individuals (P for interaction = 0.009). Conclusions Higher SII scores were associated with an increased likelihood of MetS, hyperglycemia, and high BP among middle-aged and older adults. Longitudinal studies are needed to determine the causal relationships between SII and the development of MetS, as well as to assess the potential role of SII as a screening tool in clinical practice.
C1 [Ramezankhani, Azra; Tohidi, Maryam; Hadaegh, Farzad] Shahid Beheshti Univ Med Sci, Res Inst Metab & Obes Disorders, Res Inst Endocrine Sci, Prevent Metab Disorders Res Ctr, POB 19395-4763,Floor 3th,24,Yemen St,Shahid Chamra, Tehran, Iran.
C3 Shahid Beheshti University Medical Sciences
RP Hadaegh, F (corresponding author), Shahid Beheshti Univ Med Sci, Res Inst Metab & Obes Disorders, Res Inst Endocrine Sci, Prevent Metab Disorders Res Ctr, POB 19395-4763,Floor 3th,24,Yemen St,Shahid Chamra, Tehran, Iran.
EM ma.ramezankhani@gmail.com; tohidimaryam@yahoo.com;
   fzhadaegh@endocrine.ac.ir
RI hadaegh, farzad/K-2460-2017; Ramezankhani, Azra/K-2507-2017; Tohidi,
   Maryam/V-2261-2019
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NR 58
TC 0
Z9 0
U1 2
U2 2
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1475-2840
J9 CARDIOVASC DIABETOL
JI Cardiovasc. Diabetol.
PD FEB 15
PY 2025
VL 24
IS 1
AR 78
DI 10.1186/s12933-025-02629-4
PG 13
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism
GA X0P5W
UT WOS:001422479000003
PM 39955525
OA gold
DA 2025-06-11
ER

PT J
AU Sanee, A
   Somrongthong, R
   Plianbangchang, S
AF Sanee, Aree
   Somrongthong, Ratana
   Plianbangchang, Samlee
TI The positive effects of a peer-led intervention system for individuals
   with a risk of metabolic syndrome
SO JOURNAL OF MULTIDISCIPLINARY HEALTHCARE
LA English
DT Article
DE peer-led intervention; individuals; metabolic syndrome
ID RANDOMIZED CONTROLLED-TRIAL; SELF-MANAGEMENT; OUTCOMES; HEALTH;
   COMMUNITY; NUTRITION; EDUCATION; BEHAVIOR; WOMEN
AB Background: Metabolic syndrome (MetS) is a major health risk in Thailand. Although it is reported that females have a higher rate of MetS than males, very few peer-led intervention studies have been conducted on specific groups, such as seamstresses, at risk of MetS. This study aimed to evaluate the effect of a peer-led intervention program on reducing MetS risk factors in individuals working in Thai Uniform Sewing Military Factories.
   Methods: A quasiexperimental program was introduced using a pre-and posttest design that was applied to female sewing factory workers selected for this research. All participants had at least one of the key MetS symptoms. The experimental group (N=50 participants) received 12 weekly peer-led individual support discussion sessions that included both dietary and physical activity (PA) advice and the control group (N=50 participants) followed their usual daily routines. The Student's t-test and the Pearson's chi-squared test were used to compare the differences of baseline data and analysis of variance was used for analysis of the data after intervention.
   Results: The results showed that after 3 months of participation, when compared to the control group, the experimental group had significantly improved systolic blood pressure (BP) (P=0.04), diastolic BP (P<0.001), PA (P=0.05), knowledge scores of MetS, perception of MetS and risk factors (P<0.001), and stress assessment (P=0.002). Waist circumference, body mass index, and Food Frequency Questionnaire score were not significantly different but still improved.
   Conclusion: Findings from this study suggest that a peer-led support program can be introduced as an effective means of improving the behaviors of mostly sedentary factory workers at risk of MetS caused by working habits that are detrimental to health.
C1 [Sanee, Aree; Somrongthong, Ratana; Plianbangchang, Samlee] Chulalongkorn Univ, Coll Publ Hlth Sci, Inst Bldg 3,10 Floor,Soi Chulalongkorn 62, Bangkok 10330, Thailand.
C3 Chulalongkorn University
RP Sanee, A (corresponding author), Chulalongkorn Univ, Coll Publ Hlth Sci, Inst Bldg 3,10 Floor,Soi Chulalongkorn 62, Bangkok 10330, Thailand.
EM aoodya@yahoo.com
RI Somrongthong, Ratana/D-6814-2015
OI Somrongthong, Ratana/0000-0003-4425-1760
FU 90th Anniversary of Chulalongkorn University Scholarship under the
   Ratchadaphisek Somphot Fund, Chulalongkorn University
   [GCU-GR1125594023D]
FX This study was supported by the 90th Anniversary of Chulalongkorn
   University Scholarship under the Ratchadaphisek Somphot Fund,
   Chulalongkorn University (Grant no GCU-GR1125594023D). The authors thank
   Mrs Marina Moore, College of Public Health Sciences, Chulalongkorn
   University.
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NR 37
TC 5
Z9 5
U1 0
U2 8
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-2390
J9 J MULTIDISCIP HEALTH
JI J. Multidiscip. Healthc.
PY 2017
VL 10
BP 293
EP 300
DI 10.2147/JMDH.S142272
PG 8
WC Health Care Sciences & Services
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Health Care Sciences & Services
GA FD9JX
UT WOS:000407839700001
PM 28860796
OA gold, Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Shanaki, M
   Hossein-Nezhad, A
   Meshkani, R
   Beigy, M
   Shirzad, M
   Pasalar, P
   Golmohammadi, T
AF Shanaki, Mehrnoosh
   Hossein-Nezhad, Arash
   Meshkani, Reza
   Beigy, Maani
   Shirzad, Mahmoud
   Pasalar, Parvin
   Golmohammadi, Taghi
TI Effects of Resveratrol on Crosstalk between Canonical B-Catenin/Wnt and
   FOXO Pathways in Coronary Artery Disease Patients with Metabolic
   Syndrome: A Case Control Study
SO IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH
LA English
DT Article
DE Coronary artery disease; Metabolic syndrome; Resveratrol; beta-catenin;
   Wnt signaling; FOXO; MnSOD
ID TYPE-2 DIABETIC-PATIENTS; BLOOD MONONUCLEAR-CELLS; FORKHEAD-BOX-O;
   OXIDATIVE STRESS; TRANSCRIPTION FACTOR; RISK-FACTORS; PPAR-DELTA;
   ANTIOXIDANT CAPACITY; THERAPEUTIC TARGET; BETA-CATENIN
AB Coronary artery disease (CAD) is the major cause of mortality and morbidity worldwide. The aim of this study was to explore the effect of resveratrol (RES) on Canonical beta-catenin/Wnt and forkhead box O(FOXO) pathways in CAD patients.
   We performed this study on 10 metabolic syndrome patients with three-vessel CAD and 10 sex-aged matched healthy subjects. The effects of RES on beta-Catenin, manganese superoxide dismutase (MnSOD), and peroxisome proliferator-activated receptor delta (PPAR-delta) expression were evaluated in peripheral blood mononuclear cells (PBMCs) of participants.
   RES could increase the MnSOD expression in CAD patients (38%, p < 0.0001). After RES treatment, the MnSOD expression of patients is still non-significantly lower than controls. In both blank and RES treatments, a significant positive correlation between beta-catenin and MnSOD mRNA expressions was found in controls, whereas no correlation between these gene expressions was found in untreated PBMCs of CAD patients. However, RES could modestly improve this pathway in CAD. RES could increase the MnSOD activity in healthy and CAD subjects (p = 0.051 and p = 0.009, respectively). Furthermore, in both blank and RES treatments, the significant correlation was found between total beta-catenin protein and the MnSOD activity in PBMCs of the controls but not in patients.
   The cross-talk between beta-catenin/Wnt and FOXO pathways was impaired in PBMCs of CAD patients. RES treatment could lead to a modest increase in the MnSOD activity independent of beta-catenin/FOXO pathway. Despite a modest improvement in the beta-catenin/FOXO pathway after RES treatment, this pathway was not completely repaired in CAD patients.
C1 [Shanaki, Mehrnoosh; Meshkani, Reza; Pasalar, Parvin; Golmohammadi, Taghi] Univ Tehran Med Sci, Sch Med, Dept Biochem, Tehran, Iran.
   [Shanaki, Mehrnoosh] Shahid Beheshti Univ Med Sci, Sch Allied Med Sci, Dept Med Lab Sci, Tehran, Iran.
   [Hossein-Nezhad, Arash] Univ Tehran Med Sci, Osteoporosis Res Ctr, Endocrinol & Metab Clin Sci Inst, Tehran, Iran.
   [Hossein-Nezhad, Arash] Boston Univ, Med Ctr, Sect Endocrinol Nutr & Diabet, Dept Med,Vitamin Skin & Bone Res Lab D, Boston, MA 02118 USA.
   [Beigy, Maani] Univ Tehran Med Sci, Students Sci Res Ctr, Tehran, Iran.
   [Shirzad, Mahmoud] Univ Tehran Med Sci, Cardiovasc Surg Dept, Tehran Heart Ctr, Tehran, Iran.
C3 Tehran University of Medical Sciences; Shahid Beheshti University
   Medical Sciences; Tehran University of Medical Sciences; Boston
   University; Tehran University of Medical Sciences; Tehran University of
   Medical Sciences
RP Golmohammadi, T (corresponding author), Univ Tehran Med Sci, Sch Med, Dept Biochem, Tehran, Iran.
EM golmoham@sina.tums.ac.ir
RI Shirvani, Arash/AAD-6246-2020; Beigy, Maani/S-4091-2019; Beigy,
   Maani/J-4446-2013; Shirvani, Arash/A-2847-2010
OI Beigy, Maani/0000-0003-2963-3533; Shirvani, Arash/0000-0003-2847-4737;
   Shanaki, Mehrnoosh/0000-0002-2684-1014; pasalar,
   parvin/0000-0002-8556-6729
FU Tehran University of Medical Sciences Grant [17001-30-01-91]
FX We are thankful to all participants of this study for their dedication
   and contribution to our study. This study was supported by Tehran
   University of Medical Sciences Grant for PhD thesis (ID:
   17001-30-01-91).
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NR 38
TC 10
Z9 11
U1 0
U2 3
PU SHAHEED BEHESHTI UNIV, SCH PHARMACY
PI TEHRAN
PA NO 10 SHAMS ALLEY, VALI-E ASR ST, TEHRAN, 00000, IRAN
SN 1735-0328
EI 1726-6890
J9 IRAN J PHARM RES
JI Iran. J. Pharm. Res.
PD SUM
PY 2016
VL 15
IS 3
BP 547
EP 559
PG 13
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA EH5FJ
UT WOS:000391797700033
PM 27980591
DA 2025-06-11
ER

PT J
AU Senkal, R
   Yemenoglu, H
   Kose, O
   Karakas, SM
   Yilmaz, A
   Akyildiz, K
   Beder, M
   Bostan, SA
AF Senkal, Reyhan
   Yemenoglu, Hatice
   Kose, Oguz
   Karakas, Sibel Mataraci
   Yilmaz, Adnan
   Akyildiz, Kerimali
   Beder, Melek
   Bostan, Semih Alperen
TI The role of interleukin-20 on inflammatory stress and periodontal tissue
   destruction in patients with metabolic syndrome and periodontitis
SO BMC ORAL HEALTH
LA English
DT Article
DE MetS; Periodontitis; IL-20; RANKL; Oxidative stress
ID GINGIVAL CREVICULAR FLUID; LIPID-PEROXIDATION LEVELS; TOTAL OXIDANT
   STATUS; OXIDATIVE STRESS; MATRIX METALLOPROTEINASE-8; CIRCULATING
   LEVELS; ASSOCIATION; SERUM; OSTEOPROTEGERIN; DISEASE
AB BackgroundThere is an increasing occurrence of periodontitis and metabolic syndrome (MetS), which is resulting in a decline in the overall quality of life. Both disorders can occur together since they are both linked to insulin resistance and systemic inflammation. However, evidence for a role of interleukin (IL)-20 in this comorbidity is very limited. This cross-sectional study aimed to comprehensively investigate, for the first time, the levels of RANKL/OPG, MMP-8 and OSI as well as the role of IL-20 in patients with MetS and periodontitis. MethodsThe study included a total of 80 individuals, divided into four groups: 20 individuals who were healthy both systemically and periodontally, 20 individuals who were systemically healthy but had periodontitis, 20 individuals who had MetS but were periodontally healthy, and 20 individuals who had both MetS and periodontitis. Periodontal clinical parameters (plaque index, gingival index, bleeding on probing, clinical attachment loss, probing pocket depth) were evaluated. Gingival crevicular fluid (GGF) and serum samples were collected and used for biochemical assays. Enzyme-linked immunosorbent assay was used to determine the levels of IL-20, receptor activator of nuclear factor kappa B ligand (RANKL)/osteoprotegerin (OPG), matrix metalloproteinase-8 (MMP-8) and oxidative stress index (OSI). ResultsIL-20 levels measured in serum and GCF were statistically significantly highest in patients with MetS and periodontitis (p = 0.001). Significant positive correlation was observed between serum and GCF IL-20 values and periodontal parameters (p < 0.05). There was a positive correlation between RANKL and RANKL/OPG levels and IL-20 and clinical parameters (p < 0.05). OSI values were found to be increased in the presence of both periodontitis and MetS (p = 0.001) and were positively correlated with serum and GCF IL-20 (p < 0.05). ConclusionsThese data from the study suggest a correlation between IL-20 and both MetS and periodontitis. IL-20 may potentially worsen the condition of periodontal tissue by increasing both the oxidative stress levels, periodontal collagen degredation and the ratio of RANKL to OPG. Trial registrationThis study was registered on ClinicTrials.gov (NCT06092853), 2023-10-10, retrospectively registered.
C1 [Senkal, Reyhan; Yemenoglu, Hatice; Kose, Oguz; Beder, Melek; Bostan, Semih Alperen] Recep Tayyip Erdogan Univ, Fac Dent, Dept Periodontol, TR-53100 Rize, Turkiye.
   [Karakas, Sibel Mataraci; Yilmaz, Adnan] Recep Tayyip Erdogan Univ, Fac Med, Dept Biochem, Rize, Turkiye.
   [Akyildiz, Kerimali] Recep Tayyip Erdogan Univ, Hlth Care Serv Vocat Sch, Dept Med Serv & Tech, Rize, Turkiye.
C3 Recep Tayyip Erdogan University; Recep Tayyip Erdogan University; Recep
   Tayyip Erdogan University
RP Yemenoglu, H (corresponding author), Recep Tayyip Erdogan Univ, Fac Dent, Dept Periodontol, TR-53100 Rize, Turkiye.
EM htcymnglu@hotmail.com
RI Akyildiz, Kerimali/O-1225-2019; Beder, Melek/NDS-2867-2025; kose,
   oguz/KHC-7197-2024; Yemenoglu, Hatice/KHD-2761-2024; Mataraci Karakas,
   Sibel/GXF-9961-2022; yilmaz, adnan/ABB-9340-2020
OI Mataraci Karakas, Sibel/0000-0001-7147-5087; Kose,
   Oguz/0000-0002-0318-2458; BEDER, MELEK/0009-0000-1483-3132; yilmaz,
   adnan/0000-0003-4842-1173
FU Scientific Research Fund of Recep Tayyip Erdogan University, Rize,
   Turkey [TDH-2022-1354]; Recep Tayyip Erdogan University Development
   Foundation [02024009018063]
FX This study has been supported by the Scientific Research Fund of Recep
   Tayyip Erdogan University, Rize, Turkey (Project No: TDH-2022-1354).
   This study has been supported by the Recep Tayyip Erdogan University
   Development Foundation (Grant number: 02024009018063).
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NR 57
TC 0
Z9 0
U1 7
U2 8
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1472-6831
J9 BMC ORAL HEALTH
JI BMC Oral Health
PD NOV 22
PY 2024
VL 24
IS 1
AR 1423
DI 10.1186/s12903-024-05224-3
PG 11
WC Dentistry, Oral Surgery & Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dentistry, Oral Surgery & Medicine
GA N2B7X
UT WOS:001362456500001
PM 39578819
OA gold, Green Accepted
DA 2025-06-11
ER

PT J
AU Winkley, K
   Graham, I
   Tylor, Y
   Chamley, M
   Rook, C
   Simpson, A
   Ismail, K
AF Winkley, Kirsty
   Graham, Isabel
   Tylor, Yvonne
   Chamley, Mark
   Rook, Caroline
   Simpson, Alan
   Ismail, Khalida
TI The psychosis and type 2 diabetes service model (PODS) population
   profile study
SO PRIMARY CARE DIABETES
LA English
DT Article
DE Type 2 diabetes; Severe mental illness; Primary care
ID MORTALITY; COHORT; HEALTH; PREVALENCE; ILLNESS
AB Objective: To describe diabetes care received and views of people with severe mental illness (SMI) and type 2 diabetes (T2D) in an inner-city primary care setting. Design: A cross-sectional study of adults with SMI and T2D from two primary care localities in south London. Methods: Medical record data was extracted on annual diabetes review and participants invited for telephone interview. Results: 125 adults participated, 37 completed interviews. 43 % were female, 48 %, 35 % and 16 % were: Black African/Caribbean, White, Asian/other ethnicity. Mean age= 59.47 years (SD:12.68), diabetes duration= 8.62 years (SD:6.10), systolic blood pressure (BP)= 133.42 mmHg (SD:17.28), diastolic BP= 81.42 mmHg (SD:8.93), BMI= 33.17 m/kg(2) (SD:7.22), HbA1c= 61.64 mmol/mol (SD:25.18). Older age (OR:1.06, 95 % C.I.:1.0, 1.10), shorter diabetes duration (OR:0.90, 95 % C.I.:0.84, 0.97) were associated with target HbA1c< /= 58 mM. Younger age and Black ethnicity were associated with BP> 140 mmHg (OR:0.94, 95 % C.I.:0.90, 0.98; OR:0.08 (95 % C.I.:0.01, 0.56). Being older was associated with cholesterol, < 5.0 mmol/mol (OR:1.06, 95 % C.I.:1.01, 1.11). Questionnaires demonstrated low physical activity, alcohol/drug use, diabetes distress, psychiatric symptoms. Interviews indicated that > 50 % wanted more support with SMI and T2D. Conclusions: Younger, black people with SMI and T2D are potentially at greater cardiometabolic risk. Interviews suggest people with T2D and SMI group require more mental health and diabetes support.
C1 [Winkley, Kirsty; Graham, Isabel; Simpson, Alan] Kings Coll London, Florence Nightingale Fac Nursing Midwifery & Palli, London, England.
   [Tylor, Yvonne; Chamley, Mark; Rook, Caroline; Simpson, Alan] Lambeth Diabet Intermediate Care Team, London, England.
   [Ismail, Khalida] Kings Coll London, Inst Psychiat Psychol & Neurosci, London, England.
C3 University of London; King's College London; University of London;
   King's College London
RP Winkley, K (corresponding author), Florence Nightingale Fac Nursing Midwifery & Palli, James Clerk Maxwell Bldg,Waterloo Rd, London SE1 8WA, England.
EM kirsty.winkley@kcl.ac.uk
RI Winkley, Kirsty/AAH-9458-2020
OI Winkley, Kirsty/0000-0002-1725-6040; Simpson, Alan/0000-0003-3286-9846
FU Burdett Trust for Nursing
FX The Burdett Trust for Nursing.
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NR 29
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 1751-9918
EI 1878-0210
J9 PRIM CARE DIABETES
JI Prim. Care Diabetes
PD JUN
PY 2025
VL 19
IS 3
BP 329
EP 333
DI 10.1016/j.pcd.2025.03.007
PG 5
WC Endocrinology & Metabolism; Primary Health Care
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; General & Internal Medicine
GA 2TC4T
UT WOS:001490669700012
PM 40189440
DA 2025-06-11
ER

PT J
AU Graham, JK
   Jenkins, D
   Iris, K
   Knudsen, M
   Kelley, C
AF Graham, Julie-Kathryn
   Jenkins, Danisha
   Iris, Kalie
   Knudsen, Morgan
   Kelley, Christina
TI The Toxic Stress of Racism and Its Relationship to Frailty
SO CLINICAL NURSING RESEARCH
LA English
DT Article
DE age; covid-19; C-reactive protein; comorbidity; Hispanic ethnicity
ID C-REACTIVE PROTEIN; HEALTH DISPARITIES; METABOLIC SYNDROME; COMORBIDITY;
   SEPSIS; PTSD; CRP
AB Significant morbidity and mortality from COVID-19-related illnesses have been observed among people of color within the United States. While theories involving healthcare inequity and political division have emerged to explain this observation, the role of chronic stress and inflammation is also being explored. Toxic stress is experienced disproportionately by race, ethnicity, and socioeconomic status and increases frailty and vulnerability to diseases such as COVID-19. C-reactive protein (CRP) is a biomarker associated with the inflammatory response that is typically elevated due to exposure to acute or chronic traumatic stress, as well as COVID-19. This study explored the relationship between CRP and Hispanic/non-Hispanic ethnicity among adults hospitalized with COVID-19 via a secondary analysis of retrospective electronic health record (EHR) data collected from a community healthcare system in Southern California. A total of 1,744 cases representing hospitalized adults with COVID-19 were reviewed. Data were extracted from the EHR to reflect demographics, medical diagnoses, medications, CRP, and comorbidity burden. Frequencies, percentages, and measures of central tendency were assessed to understand the distribution of data. Associations were conducted using Pearson's r and the chi-square test of independence. Differences between groups were examined via independent samples t-tests. The sample was 52% Hispanic, 56% male, and the mean age was 62 years (SD = 16.1). The mean age of Hispanic cases was younger than non-Hispanic cases (p < .001, eta = 0.289). Serum CRP was significantly higher in the Hispanic cases, with a high degree of association (p < .001, eta = 0.472). In addition, higher CRP levels were significantly associated with the need for mechanical ventilation (p < .001, phi(c) = 0.216). No significant relationships were found between CRP and age, body mass index (BMI), or comorbidity burden. Findings challenge the assumption that the disproportionate morbidity and mortality suffered by the Hispanic population due to COVID-19 was due to age, BMI, or comorbidities such as metabolic syndrome or heart disease. CRP in the Hispanic population should be further investigated to understand its relationship to chronic stress, frailty, and risk for COVID-19 in this population.
C1 [Graham, Julie-Kathryn; Jenkins, Danisha; Iris, Kalie; Knudsen, Morgan] San Diego State Univ, San Diego, CA USA.
   [Graham, Julie-Kathryn; Jenkins, Danisha; Kelley, Christina] Sharp HealthCare, San Diego, CA USA.
   [Graham, Julie-Kathryn] San Diego State Univ, 5500 Campanile Dr, San Diego, CA 92182 USA.
C3 California State University System; San Diego State University;
   California State University System; San Diego State University
RP Graham, JK (corresponding author), San Diego State Univ, 5500 Campanile Dr, San Diego, CA 92182 USA.
EM jegraham@sdsu.edu
OI graham, julie/0000-0002-5408-898X
CR Ahnach M, 2020, J MED BIOCHEM, V39, P500, DOI 10.5937/jomb0-27554
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NR 49
TC 0
Z9 0
U1 1
U2 2
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1054-7738
EI 1552-3799
J9 CLIN NURS RES
JI Clin. Nurs. Res.
PD JUN
PY 2024
VL 33
IS 5
SI SI
BP 301
EP 308
DI 10.1177/10547738241233050
EA MAR 2024
PG 8
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA UX3W8
UT WOS:001180957800001
PM 38454542
DA 2025-06-11
ER

PT J
AU Butler, MJ
   Muscat, SM
   Caetano-Silva, ME
   Shrestha, A
   Olmo, BMG
   Mackey-Alfonso, SE
   Massa, N
   Alvarez, BD
   Blackwell, JA
   Bettes, MN
   Demarsh, JW
   Mccusker, RH
   Allen, JM
   Barrientos, RM
AF Butler, Michael J.
   Muscat, Stephanie M.
   Caetano-Silva, Maria Elisa
   Shrestha, Akriti
   Olmo, Brigitte M. Gonzalez
   Mackey-Alfonso, Sabrina E.
   Massa, Nashali
   Alvarez, Bryan D.
   Blackwell, Jade A.
   Bettes, Menaz N.
   Demarsh, James W.
   Mccusker, Robert H.
   Allen, Jacob M.
   Barrientos, Ruth M.
TI Obesity-associated memory impairment and neuroinflammation precede
   widespread peripheral perturbations in aged rats
SO IMMUNITY & AGEING
LA English
DT Article
DE Cytokines; High fat diet; Gut microbiome
ID HIGH-FAT DIET; HYPOTHALAMIC INFLAMMATION; IMMUNE-SYSTEM; SATURATED FAT;
   WESTERN DIET; HIPPOCAMPAL; MICROBIOME; AMYGDALA; ANXIETY; MICE
AB BackgroundObesity and metabolic syndrome are major public health concerns linked to cognitive decline with aging. Prior work from our lab has demonstrated that short-term high fat diet (HFD) rapidly impairs memory function via a neuroinflammatory mechanism. However, the degree to which these rapid inflammatory changes are unique to the brain is unknown. Moreover, deviations in gut microbiome composition have been associated with obesity and cognitive impairment, but how diet and aging interact to impact the gut microbiome, or how rapidly these changes occur, is less clear. Thus, our study investigated the impact of HFD after two distinct consumption durations: 3 months (to model diet-induced obesity) or 3 days (to detect the rapid changes occurring with HFD) on memory function, anxiety-like behavior, central and peripheral inflammation, and gut microbiome profile in young and aged rats.ResultsOur data indicated that both short-term and long-term HFD consumption impaired memory function and increased anxiety-like behavior in aged, but not young adult, rats. These behavioral changes were accompanied by pro- and anti-inflammatory cytokine dysregulation in the hippocampus and amygdala of aged HFD-fed rats at both time points. However, changes to fasting glucose, insulin, and inflammation in peripheral tissues such as the distal colon and visceral adipose tissue were increased in young and aged rats only after long-term, but not short-term, HFD consumption. Furthermore, while subtle HFD-induced changes to the gut microbiome did occur rapidly, robust age-specific effects were only present following long-term HFD consumption.ConclusionsOverall, these data suggest that HFD-evoked neuroinflammation, memory impairment, and anxiety-like behavior in aging develop quicker than, and separately from the peripheral hallmarks of diet-induced obesity.
C1 [Butler, Michael J.; Muscat, Stephanie M.; Olmo, Brigitte M. Gonzalez; Mackey-Alfonso, Sabrina E.; Massa, Nashali; Alvarez, Bryan D.; Blackwell, Jade A.; Bettes, Menaz N.; Demarsh, James W.; Barrientos, Ruth M.] Ohio State Univ, Inst Behav Med Res, 460 Med Ctr Dr, Columbus, OH 43210 USA.
   [Muscat, Stephanie M.; Barrientos, Ruth M.] Ohio State Univ, Dept Neurosci, Columbus, OH 43210 USA.
   [Caetano-Silva, Maria Elisa; Shrestha, Akriti; Mccusker, Robert H.; Allen, Jacob M.] Univ Illinois, Dept Hlth & Kinesiol, Urbana, IL USA.
   [Mackey-Alfonso, Sabrina E.] Ohio State Univ, Med Scientist Training Program, Columbus, OH USA.
   [Alvarez, Bryan D.] Ohio State Univ, Neurosci Grad Program, Columbus, OH USA.
   [Blackwell, Jade A.] Ohio State Univ, MCDB Grad Program, Columbus, OH USA.
   [Barrientos, Ruth M.] Ohio State Univ, Dept Psychiat & Behav Hlth, 460 Med Ctr Dr, Columbus, OH 43210 USA.
   [Barrientos, Ruth M.] Ohio State Univ, Chron Brain Injury Program, Discovery Themes Initiat, Columbus, OH 43210 USA.
C3 University System of Ohio; Ohio State University; University System of
   Ohio; Ohio State University; University of Illinois System; University
   of Illinois Urbana-Champaign; University System of Ohio; Ohio State
   University; University System of Ohio; Ohio State University; University
   System of Ohio; Ohio State University; University System of Ohio; Ohio
   State University; University System of Ohio; Ohio State University
RP Barrientos, RM (corresponding author), Ohio State Univ, Inst Behav Med Res, 460 Med Ctr Dr, Columbus, OH 43210 USA.; Barrientos, RM (corresponding author), Ohio State Univ, Dept Neurosci, Columbus, OH 43210 USA.; Barrientos, RM (corresponding author), Ohio State Univ, Dept Psychiat & Behav Hlth, 460 Med Ctr Dr, Columbus, OH 43210 USA.; Barrientos, RM (corresponding author), Ohio State Univ, Chron Brain Injury Program, Discovery Themes Initiat, Columbus, OH 43210 USA.
EM ruth.barrientos@osumc.edu
RI Barrientos, Ruth/P-4734-2019
OI Allen, Jacob/0000-0001-9476-7605
FU National Institute on Aging [RF1AG028271, R03AG067061]
FX This work is supported in part by grants from the National Institute on
   Aging RF1AG028271 and R03AG067061 to RMB
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NR 72
TC 0
Z9 0
U1 2
U2 2
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1742-4933
J9 IMMUN AGEING
JI Immun. Ageing
PD JAN 3
PY 2025
VL 22
IS 1
AR 2
DI 10.1186/s12979-024-00496-3
PG 21
WC Geriatrics & Gerontology; Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology; Immunology
GA R1L5B
UT WOS:001389152900001
PM 39754121
OA gold
DA 2025-06-11
ER

PT J
AU Kawaguchi, T
   Ueno, T
   Nogata, Y
   Hayakawa, M
   Koga, H
   Torimura, T
AF Kawaguchi, Takumi
   Ueno, Takato
   Nogata, Yoichi
   Hayakawa, Masako
   Koga, Hironori
   Torimura, Takuji
TI Wheat-bran autolytic peptides containing a branched-chain amino acid
   attenuate non-alcoholic steatohepatitis via the suppression of oxidative
   stress and the upregulation of AMPK/ACC in high-fat diet-fed mice
SO INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
LA English
DT Article
DE wheat; bran; non-alcoholic steatohepatitis; oxidative stress;
   AMP-activated protein kinase
ID C VIRUS POLYPROTEIN; LIVER-DISEASE; CONTROLLED-TRIAL; VITAMIN-E;
   HEPATOCELLULAR-CARCINOMA; METABOLIC SYNDROME; RAT MODEL; RECEPTOR;
   PIOGLITAZONE; CHOLESTASIS
AB Whole-wheat intake is known to reduce the risk of metabolic syndrome. However, the active component remains unclear. Recently, we identified bioactive peptides [leucinearginine-proline (LRP) and leucine-glutamine-proline (LQP)] from wheat bran autolytic hydrolysate. The present study aimed to investigate the effects of LRP and LQP on non-alcoholic steatohepatitis (NASH) in a mouse model. We also evaluated the effects of these peptides on oxidative stress and on the AMP-activated protein kinase (AMPK) signaling pathway, two major pathogenic factors of NASH. Seven-week-old male C57BL/6 mice were fed a high-fat diet for 10 weeks and administered water supplemented with 0.05% LRP, 0.20% LRP, 0.05% LQP, or 0.20% LQP (each n=5) or distilled water (control; n=5) ad libitum. Oxidative stress was evaluated by measuring the serum levels of diacron reactive oxygen metabolite (d-ROM) and biological antioxidant potential (BAP). Hepatic expression of phosphorylated AMPK and phosphorylated acetyl-CoA carboxylase (ACC) were evaluated by immunoblotting. The result showed that non-alcoholic fatty liver disease activity score was significantly decreased in all types of treatment. Serum d-ROM levels were significantly decreased in the 0.20% LRP group, but not in the 0.05% LRP, 0.05% LQP, and 0.20% LQP groups. Serum BAP levels were significantly increased in the 0.05% LRP and 0.20% LRP groups, but not in the 0.05% LQP and 0.20% LQP groups. Immunoblotting analysis revealed that the expression of phospho-AMPK was increased whereas that of phospho-ACC was decreased in the 0.20% LQP group. In conclusion, we demonstrated that both LRP and LQP alleviated the severity of NASH in a high-fat diet-induced NASH mouse model. In addition, we showed that LRP and LQP modulated oxidative stress and upregulated AMPK/ACC, respectively. Thus, LRP and LQP may constitute clinically applicable therapeutic agents for NASH.
C1 [Kawaguchi, Takumi; Koga, Hironori; Torimura, Takuji] Kurume Univ, Sch Med, Dept Med, Div Gastroenteorl, 67 Asahi Machi, Kurume, Fukuoka 8300011, Japan.
   [Ueno, Takato] Asakura Med Assoc Hosp, Asakura, Japan.
   [Ueno, Takato; Hayakawa, Masako; Koga, Hironori; Torimura, Takuji] Kurume Univ, Liver Canc Div, Res Ctr Innovat Canc Therapy, Kurume, Fukuoka, Japan.
   [Nogata, Yoichi] NARO Western Reg Agr Res Ctr, Zentsuji, Kagawa, Japan.
C3 Kurume University; Kurume University; National Agriculture & Food
   Research Organization - Japan
RP Kawaguchi, T (corresponding author), Kurume Univ, Sch Med, Dept Med, Div Gastroenteorl, 67 Asahi Machi, Kurume, Fukuoka 8300011, Japan.
EM takumi@med.kurume-u.ac.jp
FU Japan Agency for Medical Research and Development, AMED
FX This study is supported by the Research Program on Hepatitis from Japan
   Agency for Medical Research and Development, AMED.
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NR 41
TC 27
Z9 37
U1 0
U2 19
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1107-3756
EI 1791-244X
J9 INT J MOL MED
JI Int. J. Mol. Med.
PD FEB
PY 2017
VL 39
IS 2
BP 407
EP 414
DI 10.3892/ijmm.2016.2831
PG 8
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA EL9GK
UT WOS:000394928200019
PM 28000843
OA Bronze
DA 2025-06-11
ER

PT J
AU Ceolotto, G
   Bevilacqua, M
   Papparella, I
   Baritono, E
   Franco, L
   Corvaja, C
   Mazzoni, M
   Semplicini, A
   Avogaro, A
AF Ceolotto, G
   Bevilacqua, M
   Papparella, I
   Baritono, E
   Franco, L
   Corvaja, C
   Mazzoni, M
   Semplicini, A
   Avogaro, A
TI Insulin generates free radicals by an NAD(P)H, phosphatidylinositol
   3′-kinase-dependent mechanism in human skin fibroblasts ex vivo
SO DIABETES
LA English
DT Article
ID ACTIVATED PROTEIN-KINASE; OXIDATIVE STRESS; NADPH OXIDASE;
   CARDIOVASCULAR-DISEASES; DEPENDENT ACTIVATION; SIGNALING PATHWAYS;
   CELL-SURVIVAL; RESISTANCE; HYPERTENSION; HYPERINSULINEMIA
AB Oxidative stress may be involved in the development of vascular complications associated with diabetes; however, the molecular mechanism responsible for increased production of free radicals in diabetes remains uncertain. Therefore, we examined whether acute hyperinsulinemia increases the production of free radicals and whether this condition affects proliferative extracellular signal-regulated kinase (ERK-1 and -2) signaling in human fibroblasts in vitro. Insulin treatment significantly increased intracellular superoxide anion (O-2(-)) production, an effect completely abolished by Tiron, a cell-permeable superoxide dismutase (SOD) mimetic and by polyethylene glycol (PEG)-SOD, but not by PEG catalase. Furthermore, insulin-induced O-2(-) production was attenuated by the NAD(P)H inhibitor apocynin, but not by rotenone or oxypurinol. Inhibition of the phosphatidylinositol 3'-kinase (PI 3'-kinase) pathway with LY294002 blocked insulin-stimulated O-2(-) production, suggesting a direct involvement of PI 3'-kinase in the activation of NAD(P)H oxidase. The insulin-induced free radical production led to membranous translocation of p47phox and markedly enhanced ERK-1 and -2 activation in human fibroblasts. In conclusion, these findings provided direct evidence that elevated insulin levels generate O-2(-) by an NAD(P)H-dependent mechanism that involves the activation of PI W-kinase and stimulates ERK-1- and ERK-2-dependent pathways. This effect of insulin may contribute to the pathogenesis and progression of cardiovascular disease in the insulin resistance syndrome.
C1 Univ Padua, Dept Clin & Expt Med, Sch Med, I-35128 Padua, Italy.
   Univ Padua, Dept Phys Chem, Padua, Italy.
C3 University of Padua; University of Padua
RP Univ Padua, Dept Clin & Expt Med, Sch Med, Via Giustiniani 2, I-35128 Padua, Italy.
EM angelo.avogaro@unipd.it
RI Avogaro, Angelo/S-3808-2016; Franco, Laercio/H-3814-2013; Franco,
   Lorenzo/Q-6629-2017; Semplicini, Andrea/B-5959-2013
OI AVOGARO, ANGELO/0000-0002-1177-0516; Franco,
   Lorenzo/0000-0003-3548-4423; Semplicini, Andrea/0000-0003-0652-0739;
   Ceolotto, Giulio/0000-0002-4687-8033
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NR 39
TC 69
Z9 80
U1 0
U2 0
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0012-1797
EI 1939-327X
J9 DIABETES
JI Diabetes
PD MAY
PY 2004
VL 53
IS 5
BP 1344
EP 1351
DI 10.2337/diabetes.53.5.1344
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 817DD
UT WOS:000221157300022
PM 15111505
DA 2025-06-11
ER

PT J
AU Xu, MX
   Wang, M
   Yang, WW
AF Xu, Min-Xuan
   Wang, Ming
   Yang, Wei-Wei
TI RETRACTED: Gold-quercetin nanoparticles prevent metabolic
   endotoxemia-induced kidney injury by regulating TLR4/NF-κB signaling and
   Nrf2 pathway in high fat diet fed mice (Retracted Article)
SO INTERNATIONAL JOURNAL OF NANOMEDICINE
LA English
DT Article; Retracted Publication
DE gold-quercetin nanoparticles; kidney injury; podocytes; TLR4/NF-kappa B;
   Nrf2
ID AMELIORATE OXIDATIVE STRESS; BLOOD-PRESSURE; INDUCED OBESITY; MOUSE
   MODEL; INFLAMMATION; DISEASE; INHIBITION; ACTIVATION; FIBROSIS; CURCUMIN
AB High-fat diet-induced metabolic syndrome followed by chronic kidney disease caused by intestinal endotoxemia have received extensive attention. Toll-like receptor 4 (TLR4)/ nuclear factor-kappa B (NF-kappa B) and oxidative stress-related Nrf2/Keap1 were regarded as the key target points involved in metabolic inflammation and kidney injury. However, the molecular mechanism of interaction between TLR4/NF-kappa B and Nrf2 activation in high-fat diet-induced renal injury is not absolutely understood. Quercetin, a natural product, has been reported to possess antitumor and anti-inflammatory effects. In this regard, this study attempted to prepare poly(D, L-lactide-co-glycolide)-loaded gold nanoparticles precipitated with quercetin (GQ) to investigate the anti-inflammatory and anti-oxidative stress effects in high-fat diet-induced kidney failure. For this study, C57BL/6 mice fed fat-rich fodder were used as the metabolic syndrome model to evaluate the protective effects of GQ on kidney injury and to determine whether TLR4/NF-kappa B and Nrf2 pathways were associated with the process. Moreover, histological examinations, enzyme-linked immunosorbent assay, Western blot, and basic blood tests and systemic inflammation-related indicators were used to investigate the inhibitory effects of GQ and underlying molecular mechanism by which it may reduce renal injury. Of note, podocyte injury was found to participate in endotoxin-stimulated inflammatory response. TLR4/NF-kappa B and Nrf2 pathways were upregulated with high-fat diet intake in mice, resulting in reduction of superoxide dismutase activity and increase in superoxide radical, H2O2, malondialdehyde, XO, XDH, and XO/XDH ratio. In addition, upregulation of TLR4/NF-kappa B and oxidative stress by endotoxin were observed in vitro, which were suppressed by GQ administration, ultimately alleviating podocyte injury. These findings indicated that GQ could restore the metabolic disorders caused by high-fat diet, which suppresses insulin resistance, lipid metabolic imbalance, and proinflammatory cytokine production. Also, it may prevent kidney injury by inhibition of TLR4/NF-kappa B and oxidative stress, further increasing superoxide dismutase activity.
C1 [Xu, Min-Xuan] Chongqing Univ Educ, Sch Biol & Chem Engn, Chongqing Key Lab Med Resources Three Gorges Rese, Chongqing, Peoples R China.
   [Xu, Min-Xuan] Nanjing Univ, Coll Engn & Appl Sci, Nanjing, Jiangsu, Peoples R China.
   [Wang, Ming] Zhejiang Univ, Dept Urol, Affiliated Hosp 2, Sch Med, Hangzhou, Zhejiang, Peoples R China.
   [Yang, Wei-Wei] Nanjing Med Univ, Dept Nephrol, Huaian Peoples Hosp 1, 6 Beijing Rd West, Nanjing 223300, Jiangsu, Peoples R China.
C3 Chongqing University of Education; Nanjing University; Zhejiang
   University; Nanjing Medical University
RP Yang, WW (corresponding author), Nanjing Med Univ, Dept Nephrol, Huaian Peoples Hosp 1, 6 Beijing Rd West, Nanjing 223300, Jiangsu, Peoples R China.
EM yangweiweihuaian@126.com
OI Xu, Minxuan/0000-0002-0742-4717
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NR 55
TC 53
Z9 59
U1 0
U2 40
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-2013
J9 INT J NANOMED
JI Int. J. Nanomed.
PY 2017
VL 12
BP 327
EP 345
DI 10.2147/IJN.S116010
PG 19
WC Nanoscience & Nanotechnology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics; Pharmacology & Pharmacy
GA EG7CP
UT WOS:000391203200001
PM 28115850
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Liu, Y
   Wang, D
   Li, D
   Sun, RF
   Xia, M
AF Liu, Yan
   Wang, Duan
   Li, Di
   Sun, Ruifang
   Xia, Min
TI Associations of retinol-binding protein 4 with oxidative stress,
   inflammatory markers, and metabolic syndrome in a middle-aged and
   elderly Chinese population
SO DIABETOLOGY & METABOLIC SYNDROME
LA English
DT Article
DE RBP4; Oxidative stress; Inflammatory markers; Diabetes mellitus
ID IMPAIRED GLUCOSE-TOLERANCE; C-REACTIVE PROTEIN; INSULIN-RESISTANCE;
   WEIGHT-LOSS; RETINOL-BINDING-PROTEIN-4; OBESITY; PLASMA; RBP4;
   DYSREGULATION; ADIPONECTIN
AB Background: Retinol-binding protein 4 (RBP4), a novel adipokine secreted by adipocytes and the liver, has elevated levels in type 2 diabetes mellitus (T2DM). However, its association with human metabolic diseases remains controversial. The present study was designed to investigate the associations of plasma RBP4 levels with oxidative stress, inflammatory markers, and metabolic syndrome (MetS) in a Chinese population.
   Method: We evaluated plasma RBP4 levels in a cross-sectional sample of 1748 Chinese men and women aged 50 to 70 years in Guangzhou using an in-house developed and validated sandwich ELISA. Plasma glucose, insulin, lipid profile, serum adiponectin, adipocyte fatty acid-binding protein (A-FABP), 8-iso-prostaglandin F2a (8-iso PGF2a), 13-(S)-hydroxyoctadecadienoic acid (13-HODE), high-sensitivity C-reactive protein (hsCRP), interleukin 6 (IL6), monocyte chemotactic protein 1 (MCP1) and tumor necrosis factor a (TNFa) were all measured. MetS was defined according to the updated National Cholesterol Education Program Adult Treatment Panel III criteria for Asian Americans.
   Results: Circulating RBP4 levels were positively correlated with A-FABP (r = 0.104, P < 0.001), 8-iso PGF2a (0.236, P < 0.001), and 13-HODE (0.204, P < 0.001) and were inversely correlated with HDL cholesterol (r = -0.072, P = 0.004). After multivariable adjustment, the RBP4 levels were strongly associated with MetS and its components. The ORs (95% CIs) for the comparisons of the extreme quartiles of RBP4 were 3.46 (2.87, 4.42) for MetS, 5.92 (4.47, 8.02) for hypertriglyceridemia, 1.42 (1.11, 1.68) for reduced HDL cholesterol, 1.87 (1.48, 2.36) for central obesity and 2.74 (2.15, 3.36) for hyperglycemia (all P < 0.001). When we further controlled for adipokines, markers of oxidative stress and proinflammatory response, the association of RBP4 with central obesity was abolished but not the association with other MetS components.
   Conclusions: Plasma RBP4 levels are associated with an adverse profile of oxidative stress and inflammatory markers and an increased risk of MetS in this Chinese population. These associations are independent of conventional risk factors.
C1 [Liu, Yan; Li, Di; Sun, Ruifang; Xia, Min] Guangdong Prov Key Lab Food Nutr & Hlth, Guangzhou, Guangdong, Peoples R China.
   [Liu, Yan; Wang, Duan; Li, Di; Sun, Ruifang; Xia, Min] Sun Yat Sen Univ, Sch Publ Hlth, Dept Nutr, Guangzhou 510080, Guangdong, Peoples R China.
C3 Sun Yat Sen University
RP Xia, M (corresponding author), Guangdong Prov Key Lab Food Nutr & Hlth, Guangzhou, Guangdong, Peoples R China.
EM xiamin@mail.sysu.edu.cn
FU National Natural Science Foundation of China [81072301]; National
   Natural Science Foundation from Guangdong Province [S2012020011104];
   Guangdong Province Universities and Colleges Funded Scheme; Guangzhou
   City Science and Technology Project [12C22061588]
FX This study was supported by grants from the National Natural Science
   Foundation of China (No. 81072301) and the National Natural Science
   Foundation from Guangdong Province (No. S2012020011104). The project was
   supported by the Guangdong Province Universities and Colleges Funded
   Scheme (2011) and the Guangzhou City Science and Technology Project
   (12C22061588).
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NR 38
TC 45
Z9 52
U1 0
U2 22
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1758-5996
J9 DIABETOL METAB SYNDR
JI Diabetol. Metab. Syndr.
PD FEB 24
PY 2014
VL 6
AR 25
DI 10.1186/1758-5996-6-25
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA AB9HZ
UT WOS:000332104000001
PM 24559154
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Tamashiro, KLK
   Hegeman, MA
   Nguyen, MMN
   Melhorn, SJ
   Ma, LY
   Woods, SC
   Sakai, RR
AF Tamashiro, Kellie L. K.
   Hegeman, Maria A.
   Nguyen, Mary M. N.
   Melhorn, Susan J.
   Ma, Li Yun
   Woods, Stephen C.
   Sakai, Randall R.
TI Dynamic body weight and body composition changes in response to
   subordination stress
SO PHYSIOLOGY & BEHAVIOR
LA English
DT Article; Proceedings Paper
CT Annual Meeting of the Society-for-the-Study-of-Ingestive-Behavior
CY JUL 18-22, 2006
CL Naples, FL
SP Soc Study Ingest Behav
DE dominance; hierarchy; social stress; obesity; food intake; high fat
   diet; anhedonia
ID CHRONIC SOCIAL STRESS; MALE-RATS; PSYCHOSOCIAL STRESS; SUCROSE
   CONSUMPTION; RECEPTOR-BINDING; BRAIN-REGIONS; TREE SHREWS; FOOD-INTAKE;
   WILD RATS; MODEL
AB Social stress is prevalent in many facets of modem society. Epidemiological data suggest that stress is linked to the development of overweight, obesity and metabolic disease. Although there are strong associations between the incidence of obesity with stress and elevated levels of hormones such as cortisol, there are limited animal models to allow investigation of the etiology of increased adiposity resulting from exposure to stress. Perhaps more importantly, an animal model that mirrors the consequences of stress in humans will provide a vehicle to develop rational clinical therapy to treat or prevent adverse outcomes from exposure to chronic social stress. In the visible burrow system (VBS) model of chronic social stress mixed gender colonies are housed for 2 week periods during which male rats of the colony quickly develop a dominance hierarchy. We found that social stress has significant effects on body weight and body composition such that subordinate rats progressively develop characteristics of obesity that occurs, in part, through neuroendocrine alterations and changes in food intake amount. Although subordinate rats are hyperphagic following social stress they do not increase their intake of sucrose solution as control and dominants do suggesting that they are anhedonic. Consumption of a high fat diet does not appear to affect development of a social hierarchy and appears to enhance the effect that chronic stress has on body composition. The visible burrow system (VBS) model of social stress may be a potential laboratory model for studying stress-associated metabolic disease, including the metabolic syndrome. (C) 2007 Elsevier Inc. All rights reserved.
C1 Univ Cincinnati, Genome Res Inst, Dept Psychiat, Cincinnati, OH 45237 USA.
   Univ Cincinnati, Grad Program Neurosci, Cincinnati, OH 45237 USA.
C3 University System of Ohio; University of Cincinnati; University System
   of Ohio; University of Cincinnati
RP Sakai, RR (corresponding author), Univ Cincinnati, Genome Res Inst, Dept Psychiat, 2170 E Galbraith Rd E-212, Cincinnati, OH 45237 USA.
EM randall.sakai@uc.edu
OI Tamashiro, Kellie/0000-0002-9398-8796
FU NIDDK NIH HHS [DK-17844, R37 DK017844, DK066596, R01 DK017844, R01
   DK066596] Funding Source: Medline; NINDS NIH HHS [NS047791, F31
   NS047791] Funding Source: Medline
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NR 71
TC 92
Z9 104
U1 0
U2 17
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0031-9384
J9 PHYSIOL BEHAV
JI Physiol. Behav.
PD JUL 24
PY 2007
VL 91
IS 4
SI SI
BP 440
EP 448
DI 10.1016/j.physbeh.2007.04.004
PG 9
WC Psychology, Biological; Behavioral Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI); Conference Proceedings Citation Index - Science (CPCI-S); Conference Proceedings Citation Index - Social Science &amp; Humanities (CPCI-SSH)
SC Psychology; Behavioral Sciences
GA 196HS
UT WOS:000248472900013
PM 17512562
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Yeo, HY
   Kim, OY
   Lim, HH
   Kim, JY
   Lee, JH
AF Yeo, Hyun Yang
   Kim, Oh Yoen
   Lim, Hyo Hee
   Kim, Ji Young
   Lee, Jong Ho
TI Association of serum lycopene and brachial-ankle pulse wave velocity
   with metabolic syndrome
SO METABOLISM-CLINICAL AND EXPERIMENTAL
LA English
DT Article
ID ANTIOXIDANT CONCENTRATIONS; CAROTID ATHEROSCLEROSIS;
   CARDIOVASCULAR-DISEASE; INSULIN-RESISTANCE; OXIDATIVE STRESS; TOMATO
   LYCOPENE; HUMAN HEALTH; ALL-CAUSE; RISK; CAROTENOIDS
AB Metabolic syndrome (MetS) is known to inversely correlate with antioxidant status. Recently, it has been reported that MetS is associated with arterial stiffness, a composite risk factor for early atherosclerosis. In addition, our recent study for healthy women showed an inverse relationship between arterial stiffness and circulating lycopene. Therefore, this study aimed to investigate the interrelationship between arterial stiffness, antioxidant status, and the risk of MetS. Korean men (N = 299) were subgrouped according to the number of MetS risk factors (RF 0, RF 1-2, RF >= 3). Anthropometric parameters, brachial-ankle pulse wave velocity (baPWV; a marker of arterial stiffness), antioxidants (lycopene, beta-carotene, alpha-tocopherol), lipid profiles, glucose, insulin, and oxidative stress (low-density lipoprotein [LDL] particle size, oxidized LDL) were measured. Corresponding to the number of MetS RF, baPWV (1306 +/- 17, 1364 +/- 16, and 1420 +/- 33 cm/s; P < .001) and insulin resistance (1.5 +/- 0.1, 1.9 +/- 0.1, and 2.7 +/- 0.2; P < .001) gradually increased after adjustment for age, body mass index, smoking, and drinking, whereas serum lycopene among antioxidants and LDL particle size gradually decreased (0.036 +/- 0.001, 0.031 +/- 0.001, and 0.028 +/- 0.001 mmol/L; P = .004 and 23.9 +/- 0.1, 23.7 +/- 0.1, and 23.3 +/- 0.1 nm; P < .001, respectively). Brachial-ankle pulse wave velocity inversely correlated with serum lycopene after adjustment for the above confounders, blood pressure, insulin resistance, and oxidative stress (r = -0.136, P < .05). Oxidative stress markers also significantly correlated with baPWV as well as serum lycopene. Study subjects were divided into 2 groups by the median level of serum lycopene. When serum lycopene was lower than median level (<= 0.0294 mmol/L), baPWV was significantly higher in MetS subjects than non-MetS subjects (1436 +/- 41 vs 1367 +/- 23 cm/s) after adjustment for age, body mass index, smoking, drinking, and oxidative stress (P = .041). However, when serum lycopene levels were high, no statistically significant difference was observed between the 2 subject groups (1386 +/- 36 vs 1326 +/- 13 cm/s). In conclusion, our result shows the interrelationship between circulating lycopene, baPWV, and MetS. In addition, much enhanced baPWV in MetS may be associated with lower lycopene concentration. (C) 2011 Elsevier Inc. All rights reserved.
C1 [Yeo, Hyun Yang; Kim, Oh Yoen; Lim, Hyo Hee; Kim, Ji Young; Lee, Jong Ho] Yonsei Univ, Dept Food & Nutr, Natl Res Lab Clin Nutrigenet Nutrigenom, Seoul 120749, South Korea.
   [Yeo, Hyun Yang; Kim, Oh Yoen; Kim, Ji Young; Lee, Jong Ho] Yonsei Univ, Res Inst Sci Aging, Seoul 120749, South Korea.
   [Yeo, Hyun Yang; Lee, Jong Ho] Yonsei Univ, Interdisciplinary Course Sci Aging, Grad Sch, Seoul 120749, South Korea.
C3 Yonsei University; Yonsei University; Yonsei University
RP Lee, JH (corresponding author), Yonsei Univ, Dept Food & Nutr, Natl Res Lab Clin Nutrigenet Nutrigenom, Seoul 120749, South Korea.
EM jhleeb@yonsei.ac.kr
RI Kim, Oh/AAA-6492-2022; Kim, Ji Young/HNS-6229-2023
FU National Research Foundation, Ministry of Education, Science and
   Technology [2010-0015017, M10642120002-06N4212-00210]; Korea Health 21
   R&D Projects, Ministry of Health & Welfare, Seoul, Korea [A080348]
FX This study was supported by the National Research Foundation, Ministry
   of Education, Science and Technology (Mid-career Researcher Program:
   2010-0015017, and M10642120002-06N4212-00210), and Korea Health 21 R&D
   Projects, Ministry of Health & Welfare (A080348), Seoul, Korea.
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NR 37
TC 25
Z9 27
U1 0
U2 3
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0026-0495
EI 1532-8600
J9 METABOLISM
JI Metab.-Clin. Exp.
PD APR
PY 2011
VL 60
IS 4
BP 537
EP 543
DI 10.1016/j.metabol.2010.05.003
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 743TP
UT WOS:000289041900013
PM 20580031
DA 2025-06-11
ER

PT J
AU Strohmaier, S
   Devore, EE
   Zhang, Y
   Schernhammer, ES
AF Strohmaier, S.
   Devore, E. E.
   Zhang, Y.
   Schernhammer, E. S.
TI A Review of Data of Findings on Night Shift Work and the Development of
   DM and CVD Events: a Synthesis of the Proposed Molecular Mechanisms
SO CURRENT DIABETES REPORTS
LA English
DT Review
DE Night work; Cardiovascular; Cardiometabolic; Diabetes; Circadian
   misalignment; Inflammation
ID TYPE-2 DIABETES-MELLITUS; OXIDATIVE STRESS; MELATONIN SECRETION;
   INSULIN-RESISTANCE; VASCULAR REACTIVITY; GENE-EXPRESSION;
   BLOOD-PRESSURE; HEART-DISEASE; RISK; INFLAMMATION
AB Purpose of ReviewNight shift work has become highly prevalent in our 24/7 societies, with up to 18% of the US work force working alternate shift schedules. However, studies indicate that there may be adverse health effects of chronic night work across diverse populations. These effects are likely due to misalignment of the circadian system with work schedules, mediated by the system's primary marker melatonin as well as other downstream molecules.Recent FindingsMelatonin has multiple biologic actions that are relevant to cardiometabolic disease, including modulation of oxidative stress, inflammation, and (via the melatonin receptor) vasoconstriction. Behavioral traits, such as chronotype and meal timing, have recently been shown to interact with the effects of night work on cardiometabolic health.SummaryTogether with recent findings suggesting a role for circadian genes in cardiometabolic risk, the interactions of night shift work and behavioral traits are likely to facilitate novel treatment and prevention approaches for cardiovascular disease and type 2 diabetes, incorporating aspects of clock and timing.
C1 [Strohmaier, S.; Schernhammer, E. S.] Med Univ Vienna, Ctr Publ Hlth, Dept Epidemiol, Kinderspitalgasse 15, A-1090 Vienna, Austria.
   [Strohmaier, S.; Devore, E. E.; Zhang, Y.; Schernhammer, E. S.] Harvard Med Sch, Channing Div Network Med, Boston, MA 02115 USA.
   [Schernhammer, E. S.] Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.
C3 Medical University of Vienna; Harvard University; Harvard Medical
   School; Harvard University; Harvard T.H. Chan School of Public Health
RP Schernhammer, ES (corresponding author), Med Univ Vienna, Ctr Publ Hlth, Dept Epidemiol, Kinderspitalgasse 15, A-1090 Vienna, Austria.; Schernhammer, ES (corresponding author), Harvard Med Sch, Channing Div Network Med, Boston, MA 02115 USA.; Schernhammer, ES (corresponding author), Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.
EM nksus@channing.harvard.edu; nheed@channing.harvard.edu;
   n2zhy@channing.harvard.edu; eva.schernhammer@meduniwien.ac.at
RI Schernhammer, Eva/L-7898-2018
OI Strohmaier, Susanne/0000-0002-9387-2056
FU NIOSH CDC HHS [R01 OH009803] Funding Source: Medline
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NR 74
TC 61
Z9 66
U1 1
U2 22
PU CURRENT MEDICINE GROUP
PI PHILADELPHIA
PA 400 MARKET STREET, STE 700, PHILADELPHIA, PA 19106 USA
SN 1534-4827
EI 1539-0829
J9 CURR DIABETES REP
JI Curr. Diabetes Rep.
PD DEC
PY 2018
VL 18
IS 12
AR 132
DI 10.1007/s11892-018-1102-5
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA GX5PV
UT WOS:000447802900002
PM 30343445
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Vuong, E
   Hemmings, SM
   Mhlongo, S
   Chirwa, E
   Lombard, C
   Peer, N
   Abrahams, N
   Seedat, S
AF Vuong, Eileen
   Hemmings, Sian Megan
   Mhlongo, Shibe
   Chirwa, Esnat
   Lombard, Carl
   Peer, Nasheeta
   Abrahams, Naeemah
   Seedat, Soraya
TI Adiponectin gene polymorphisms and posttraumatic stress disorder
   symptoms among female rape survivors: an exploratory study
SO EUROPEAN JOURNAL OF PSYCHOTRAUMATOLOGY
LA English
DT Article
DE Adiponectin gene; posttraumatic stress disorder; rape; trauma; biomarker
ID HARDY-WEINBERG EQUILIBRIUM; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   DENTATE GYRUS; PTSD; ASSOCIATION; DEPRESSION; CORTISOL; SCALE; RISK
AB Background: Rape is a common traumatic event which may result in the development of posttraumatic stress disorder (PTSD), yet few studies have investigated risk biomarkers in sexually traumatised individuals. Adiponectin is a novel cytokine within inflammatory and cardiometabolic pathways with evidence of involvement in PTSD. Objective: This prospective exploratory study in a sample of female rape survivors investigated the association of single nucleotide polymorphisms (SNPs) in the adiponectin gene (ADIPOQ) and posttraumatic stress symptom (PTSS) severity, and the interaction of these SNPs of interest with childhood trauma in modifying the association with PTSS severity. Method: The study involved 455 rape-exposed black South African women (mean age (SD), 25.3 years (+/- 5.5)) recruited within 20 days of being raped. PTSS was assessed using the Davidson Trauma Scale (DTS) and childhood trauma was assessed using a modified version of the Childhood Trauma Scale-Short Form Questionnaire. Eight ADIPOQ SNPs (rs17300539, rs16861194, rs16861205, rs2241766, rs6444174, rs822395, rs1501299, rs1403697) were genotyped using KASP. Mixed linear regression models were used to test additive associations of ADIPOQ SNPs and PTSS severity at baseline, 3 and 6 months following rape. Results: The mean DTS score post-sexual assault was high (71.3 +/- 31.5), with a decrease in PTSS severity shown over time for all genotypes. rs6444174TT genotype was inversely associated with baseline PTSS in the unadjusted model (beta = -13.6, 95% CI [-25.1; -2.1], p = .021). However, no genotype was shown to be significantly associated with change in PTSS severity over time and therefore ADIPOQ SNP x childhood trauma interaction was not further investigated. Conclusion: None of the ADIPOQ SNPs selected for investigation in this population were shown to be associated with change in PTSS severity over a 6-month period and therefore their clinical utility as risk biomarkers for rape-related PTSD appears limited. These SNPs should be further investigated in possible gene-gene and gene-environment interactions.
C1 [Vuong, Eileen; Hemmings, Sian Megan; Seedat, Soraya] Stellenbosch Univ, Dept Psychiat, PTSD Program, South African Res Chairs Initiat SARChI, POB 241, ZA-8000 Cape Town, South Africa.
   [Vuong, Eileen; Seedat, Soraya] Stellenbosch Univ, Dept Psychiat, Stellenbosch, South Africa.
   [Hemmings, Sian Megan; Seedat, Soraya] Stellenbosch Univ, South African Med Res Council, Genom Brain Disorders Res Unit, Cape Town, South Africa.
   [Mhlongo, Shibe; Chirwa, Esnat; Abrahams, Naeemah] South African Med Res Council, Gender & Hlth Res Unit, Cape Town, South Africa.
   [Lombard, Carl] South African Med Res Council, Biostatitist Unit, Cape Town, South Africa.
   [Peer, Nasheeta] South African Med Res Council, Noncommunicable Dis Res Unit, Durban, South Africa.
   [Peer, Nasheeta] Univ Cape Town, Dept Med, Cape Town, South Africa.
   [Abrahams, Naeemah] Univ Cape Town, Sch Publ Hlth & Family Med, Fac Hlth Sci, Cape Town, South Africa.
   [Chirwa, Esnat] Univ Witwatersrand, Fac Hlth Sci, Sch Publ Hlth, Johannesburg, South Africa.
C3 Stellenbosch University; Stellenbosch University; Stellenbosch
   University; South African Medical Research Council; South African
   Medical Research Council; South African Medical Research Council; South
   African Medical Research Council; University of Cape Town; University of
   Cape Town; University of Witwatersrand
RP Vuong, E (corresponding author), Stellenbosch Univ, Dept Psychiat, PTSD Program, South African Res Chairs Initiat SARChI, POB 241, ZA-8000 Cape Town, South Africa.
EM eileenthomas@sun.ac.za
RI Hemmings, Sian/ABF-9676-2022; Chirwa, Esnat/JJF-2631-2023; Abrahams,
   Naeemah/JAN-9361-2023
OI Seedat, Soraya/0000-0002-5118-786X; Chirwa, Esnat/0000-0003-0471-4978;
   Hemmings, Sian/0000-0001-8461-1017; Lombard, Carl/0000-0002-2136-6533;
   Abrahams, Naeemah/0000-0002-6138-6256; Thomas,
   Eileen/0000-0002-5756-7687
FU South African Research Chair in PTSD - Department of Science and
   Innovation (DSI) [UID64811]; South African Medical Research Council
   [SAMRC-RFA-IFSP-01-2013/RAPE COHORT]
FX This research is supported by: (i) The South African Research Chair in
   PTSD (SARChi UID64811) hosted by Stellenbosch University, funded by the
   Department of Science and Innovation (DSI) and administered by the South
   African National Research Foundation (NRF) and (ii) South African
   Medical Research Council in terms of the SAMRC's Flagships Awards
   Project SAMRC-RFA-IFSP-01-2013/RAPE COHORT.
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NR 93
TC 1
Z9 1
U1 0
U2 8
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 2000-8198
EI 2000-8066
J9 EUR J PSYCHOTRAUMATO
JI Eur. J. Psychotraumatol.
PD DEC 19
PY 2022
VL 13
IS 2
AR 2107820
DI 10.1080/20008066.2022.2107820
PG 15
WC Psychology, Clinical; Psychiatry
WE Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA 3T8FF
UT WOS:000840504800001
PM 35992226
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Hayden, MR
AF Hayden, Melvin R.
TI Type 2 Diabetes Mellitus Increases the Risk of Late-Onset Alzheimer's
   Disease: Ultrastructural Remodeling of the Neurovascular Unit and
   Diabetic Gliopathy
SO BRAIN SCIENCES
LA English
DT Review
DE aging; Alzheimer's disease; brain insulin resistance; db; db diabetic
   mouse model; diabetic cognopathy; insulin resistance; metabolic
   syndrome; mixed dementia; obesity; type 2 diabetes mellitus
ID MILD COGNITIVE IMPAIRMENT; BLOOD-BRAIN-BARRIER; ASTROCYTE-ENDOTHELIAL
   INTERACTIONS; MITOCHONDRIAL CASCADE HYPOTHESIS; CARDIORENAL METABOLIC
   SYNDROME; RENIN-ANGIOTENSIN SYSTEM; BODY-MASS INDEX; INTRANASAL INSULIN;
   OXIDATIVE STRESS; AMYLOID-BETA
AB Type 2 diabetes mellitus (T2DM) and late-onset Alzheimer's disease-dementia (LOAD) are increasing in global prevalence and current predictions indicate they will only increase over the coming decades. These increases may be a result of the concurrent increases of obesity and aging. T2DM is associated with cognitive impairments and metabolic factors, which increase the cellular vulnerability to develop an increased risk of age-related LOAD. This review addresses possible mechanisms due to obesity, aging, multiple intersections between T2DM and LOAD and mechanisms for the continuum of progression. Multiple ultrastructural images in female diabetic db/db models are utilized to demonstrate marked cellular remodeling changes of mural and glia cells and provide for the discussion of functional changes in T2DM. Throughout this review multiple endeavors to demonstrate how T2DM increases the vulnerability of the brain's neurovascular unit (NVU), neuroglia and neurons are presented. Five major intersecting links are considered: i. Aging (chronic age-related diseases); ii. metabolic (hyperglycemia advanced glycation end products and its receptor (AGE/RAGE) interactions and hyperinsulinemia-insulin resistance (a linking linchpin); iii. oxidative stress (reactive oxygen-nitrogen species); iv. inflammation (peripheral macrophage and central brain microglia); v. vascular (macrovascular accelerated atherosclerosis-vascular stiffening and microvascular NVU/neuroglial remodeling) with resulting impaired cerebral blood flow.
C1 [Hayden, Melvin R.] Univ Missouri, Diabet & Cardiovasc Ctr, Sch Med, Columbia, MO 65212 USA.
   [Hayden, Melvin R.] Univ Missouri, Dept Med, Div Endocrinol & Metab, Columbia, MO 65212 USA.
C3 University of Missouri System; University of Missouri Columbia;
   University of Missouri System; University of Missouri Columbia
RP Hayden, MR (corresponding author), Univ Missouri, Diabet & Cardiovasc Ctr, Sch Med, Columbia, MO 65212 USA.; Hayden, MR (corresponding author), Univ Missouri, Dept Med, Div Endocrinol & Metab, Columbia, MO 65212 USA.
EM mrh29pete@gmail.com
FU Office of Research: University of Missouri, Columbia, Missouri;
   Transmission Electron Microscope Core Facility: University of Missouri,
   Columbia, Missouri
FX This review was supported by an internal grant entitled Excellence in
   Electron Microscopy to M. R. H. by the Transmission Electron Microscope
   Core Facility and Office of Research: University of Missouri, Columbia,
   Missouri. There were no external grants provided to prepare this
   manuscript.
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NR 183
TC 55
Z9 58
U1 0
U2 22
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3425
J9 BRAIN SCI
JI Brain Sci.
PD OCT
PY 2019
VL 9
IS 10
AR 262
DI 10.3390/brainsci9100262
PG 44
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA JI5NX
UT WOS:000493515400041
PM 31569571
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Krzyzewska, A
   Kloza, M
   Kozlowska, H
AF Krzyzewska, Anna
   Kloza, Monika
   Kozlowska, Hanna
TI Comprehensive mini-review: therapeutic potential of cannabigerol - focus
   on the cardiovascular system
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Review
DE hypertension; phytocannabinoids; animal models; oxidative stress;
   inflammation; alpha-2-adrenergic receptors
ID PLANT CANNABINOID CANNABIGEROL; ARTERIAL-HYPERTENSION; OXIDATIVE STRESS;
   RECEPTOR; INFLAMMATION; INTERLEUKIN-18; CANNABIDIOL; SATIVA; MODEL; CB1
AB Backgrounds Cannabigerol (CBG) is a non-psychoactive phytocannabinoid with a broad spectrum of biological effects. However, there is still too little research on its safety especially its effects on the cardiovascular system. Due to its agonist effects on alpha-2-adrenergic receptors (alpha 2AR), it is speculated that it may have applications in the pharmacotherapy of metabolic syndrome, particularly hypertension. Thus, the aim of our review was to analyse the therapeutic potential of CBG in cardiovascular diseases.Methods The review was based on searches of the PubMed and Web of Science databases. Keywords were used to identify literature containing therapeutic and mechanistic information on CBG and its potential effects on the cardiovascular system.Results A review of the literature shows that CBG exhibits hypotensive effects in mice probably through alpha 2AR agonism. Other numerous in vitro and in vivo studies show that CBG has anti-inflammatory, antioxidant effects and also regulates cell apoptosis. Cannabigerol improved tissue sensitivity to insulin, and also showed efficacy in inhibiting platelet aggregation. However, there are reports of adverse effects of high doses of CBG on liver architecture and function, which calls into question its usefulness and safety profile.Conclusion Above mentioned beneficial properties of CBG suggest that it may be useful in treating hypertension and metabolic syndrome. However, there is still a lack of studies on the chronic administration of CBG and its effects on cardiovascular parameters in hypertension condition, which may be necessary to determine its safety and the need for future studies on other indications.
C1 [Krzyzewska, Anna; Kloza, Monika; Kozlowska, Hanna] Med Univ Bialystok, Dept Expt Physiol & Pathophysiol, Bialystok, Poland.
C3 Medical University of Bialystok
RP Krzyzewska, A (corresponding author), Med Univ Bialystok, Dept Expt Physiol & Pathophysiol, Bialystok, Poland.
EM anna.krzyzewska@umb.edu.pl
RI Kloza, Monika/T-5349-2018; Krzyżewska, Anna/GWZ-2246-2022; Kozlowska,
   Hanna/AAP-7716-2021
FU Medical University of Bialstrok;ystok
FX The author(s) declare that financial support was received for the
   research and/or publication of this article. This work was supported by
   the Medical University of Bia & lstrok;ystok.
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NR 101
TC 0
Z9 0
U1 2
U2 2
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD MAR 26
PY 2025
VL 16
AR 1561385
DI 10.3389/fphar.2025.1561385
PG 16
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 1LW4V
UT WOS:001468116400001
PM 40206058
OA gold
DA 2025-06-11
ER

PT J
AU Vileigas, DF
   de Souza, SLB
   Corrêa, CR
   Silva, CCVD
   de Campos, DHS
   Padovani, CR
   Cicogna, AC
AF Vileigas, Danielle Fernandes
   de Souza, Sergio Luiz Borges
   Correa, Camila Renata
   Silva, Carol Cristina Vagula de Almeida
   de Campos, Dijon Henrique Salome
   Padovani, Carlos Roberto
   Cicogna, Antonio Carlos
TI The effects of two types of Western diet on the induction of metabolic
   syndrome and cardiac remodeling in obese rats
SO JOURNAL OF NUTRITIONAL BIOCHEMISTRY
LA English
DT Article
DE Obesity; High-fat high-sugar diet; Metabolic diseases; Cardiac
   dysfunction; Energy metabolism; Oxidative stress; Inflammation
ID HIGH-FAT DIET; DIASTOLIC DYSFUNCTION; HIGH-CARBOHYDRATE; MOUSE MODEL;
   HEART; TERM
AB Metabolic syndrome (MetS) include obesity as a critical feature and is strongly associated with risk of cardiovascular disease (CVD). Insights into mechanisms involved in the pathophysiology of these clinical manifestations are essential for the development of therapeutic strategies. Thus, Western diets (WD) have been widely employed in diet-induced obesity (DIO) model. However, there are variations in fat and sugar proportions of such diets, making comparisons challenging. We aimed to assess the impact of two types of the WD on metabolic status and cardiac remodeling, to achieve a DIO model that better mimics the human pathogenesis of MetS-induced CVD. Male Wistar rats were distributed into three groups: control diet, Western diet fat (WDF), and Western diet sugar (WDS) for 41 weeks. Metabolic and inflammatory parameters and cardiac changes were characterized. WDF and WDS feeding promoted higher serum triglycerides, glucose intolerance, and insulin resistance, while just WDF presented inflammation in adipose tissue. WDF-fed rats showed increased catalase activity and malondialdehyde (MDA) and carbonyl protein levels, suggesting cardiac oxidative stress, while WDS-fed rats only raised MDA. Both WD equally elevated protein expressions involved in lipid metabolism, but only WDF downregulated the glycolysis pathway. Furthermore, the mechanical myocardial function was impaired in obese rats, being more relevant in WDF. In conclusion, both WD effectively triggered MetS features, although inflammation was detected just on the WDF-fed animals. Moreover, the WDF promoted a more pronounced functional, metabolic, and oxidative cardiac disorder, suggesting to be an adequate model for studying CVD in the scenario of MetS.
   (c) 2021 Elsevier Inc. All rights reserved.
C1 [Vileigas, Danielle Fernandes; de Souza, Sergio Luiz Borges; Silva, Carol Cristina Vagula de Almeida; de Campos, Dijon Henrique Salome; Cicogna, Antonio Carlos] Sao Paulo State Univ UNESP, Botucatu Med Sch, Dept Internal Med, BR-18618687 Botucatu, SP, Brazil.
   [Correa, Camila Renata] Sao Paulo State Univ UNESP, Botucatu Med Sch, Dept Patol, Botucatu, SP, Brazil.
   [Padovani, Carlos Roberto] Sao Paulo State Univ UNESP, Inst Biosci, Dept Biostat, Botucatu, SP, Brazil.
C3 Universidade Estadual Paulista; Universidade Estadual Paulista;
   Universidade Estadual Paulista
RP Vileigas, DF; Cicogna, AC (corresponding author), Sao Paulo State Univ UNESP, Botucatu Med Sch, Dept Internal Med, BR-18618687 Botucatu, SP, Brazil.
EM dani.vileigas@iq.usp; ac.cicogna@unesp.br
RI Correa, Camila/Q-2071-2019; Vileigas, Danielle/AAN-6725-2020; Padovani,
   Carlos/A-3656-2013
OI Vileigas, Danielle/0000-0002-0551-0435; Correa, Camila
   Renata/0000-0001-8493-5329
FU CAPES; Sao Paulo Research Foundation -FAPESP [2014/22152-0,
   2015/16934-8]
FX This work was supported by the CAPES and Sao Paulo Research Foundation
   -FAPESP (grant numbers: 2014/22152-0 and 2015/16934-8).
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NR 83
TC 9
Z9 11
U1 0
U2 9
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0955-2863
EI 1873-4847
J9 J NUTR BIOCHEM
JI J. Nutr. Biochem.
PD JUN
PY 2021
VL 92
AR 108625
DI 10.1016/j.jnutbio.2021.108625
EA APR 2021
PG 12
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA RS7IR
UT WOS:000643949200006
PM 33705955
DA 2025-06-11
ER

PT J
AU Seidel, G
   Meierhofer, D
   Sen, NE
   Guenther, A
   Krobitsch, S
   Auburger, G
AF Seidel, Gunnar
   Meierhofer, David
   Sen, Nesli-Ece
   Guenther, Anika
   Krobitsch, Sylvia
   Auburger, Georg
TI Quantitative Global Proteomics of Yeast PBP1 Deletion Mutants and Their
   Stress Responses Identifies Glucose Metabolism, Mitochondrial, and
   Stress Granule Changes
SO JOURNAL OF PROTEOME RESEARCH
LA English
DT Article
DE PBP1; proteome profiling; mass spectrometry; stress response;
   neurobiology
ID SACCHAROMYCES-CEREVISIAE; GENETIC MODIFIERS; MLLE DOMAIN; ATAXIN-2;
   PROTEIN; SUPPRESSION; ASSOCIATION; DISRUPTION; ACTIVATION; EXPRESSION
AB The yeast protein PBP1 is implicated in very diverse pathways. Intriguingly, its deletion mitigates the toxicity of human neurodegeneration factors. Here, we performed label-free quantitative global proteomics to identify crucial downstream factors, either without stress or under cell stress conditions (heat and NaN3). Compared to the wildtype BY4741 strain, PBP1 deletion always triggered downregulation of the key bioenergetics enzyme KGD2 and the prion protein RNQ1 as well as upregulation of the leucine biosynthesis enzyme LEU1. Without stress, enrichment of stress response factors was consistently detected for both deletion mutants; upon stress, these factors were more pronounced. The selective analysis of components of stress granules and P-bodies revealed a prominent downregulation of GIS2. Our yeast data are in good agreement with a global proteomics and metabolomics publication that the PBP1 ortholog ATAXIN-2 (ATXN2) knockout (KO) in mouse results in mitochondrial deficits in leucine/fatty acid catabolism and bioenergetics, with an obesity phenotype. Furthermore, our data provide the completely novel insight that PBP1 mutations in stress periods involve GIS2, a plausible scenario in view of previous data that both PBP1 and GIS2 relocalize from ribosomes to stress granules, interact with poly(A)-binding protein in translation regulation and prevent mitochondrial precursor overaccumulation stress (mPOS). This may be relevant for human diseases like spinocerebellar ataxias, amyotrophic lateral sclerosis, and the metabolic syndrome.
C1 [Seidel, Gunnar; Meierhofer, David; Guenther, Anika; Krobitsch, Sylvia] Max Planck Inst Mol Genet, Ihnestr 63-73, D-14195 Berlin, Germany.
   [Sen, Nesli-Ece; Auburger, Georg] Goethe Univ, Expt Neurol, Sch Med, Theodor Stern Kai 7, D-60590 Frankfurt, Germany.
C3 Max Planck Society; Goethe University Frankfurt
RP Auburger, G (corresponding author), Goethe Univ, Expt Neurol, Sch Med, Theodor Stern Kai 7, D-60590 Frankfurt, Germany.
EM auburger@em.uni-frankfurt.de
RI Meierhofer, David/V-4711-2019
OI Meierhofer, David/0000-0002-0170-868X
FU DFG [AU96/11-3, KR1949/3-1]; Max Planck Society
FX We are grateful to B. Meseck Selchow and Beata Lukazewska-McGreal for
   technical assistance. The project was financially supported by the DFG
   (AU96/11-3 and KR1949/3-1) and the Max Planck Society.
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NR 70
TC 23
Z9 27
U1 2
U2 25
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1535-3893
EI 1535-3907
J9 J PROTEOME RES
JI J. Proteome Res.
PD FEB
PY 2017
VL 16
IS 2
BP 504
EP 515
DI 10.1021/acs.jproteome.6b00647
PG 12
WC Biochemical Research Methods
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA EJ9IK
UT WOS:000393539600014
PM 27966978
OA Green Published
DA 2025-06-11
ER

PT J
AU Hauser, G
   Horvat, IB
   Rajilic-Stojanovic, M
   Krznaric-Zrnic, I
   Kukla, M
   Aljinovic-Vucic, V
   Mikolasevic, I
AF Hauser, Goran
   Benjak Horvat, Indira
   Rajilic-Stojanovic, Mirjana
   Krznaric-Zrnic, Irena
   Kukla, Michail
   Aljinovic-Vucic, Vedrana
   Mikolasevic, Ivana
TI Intestinal Microbiota Modulation by Fecal Microbiota Transplantation in
   Nonalcoholic Fatty Liver Disease
SO BIOMEDICINES
LA English
DT Review
DE nonalcoholic fatty liver disease; gut-liver axis; gut microbiota; NAFLD
   pathogenesis; fecal microbiota transplantation
ID CLOSTRIDIUM-DIFFICILE INFECTION; IRRITABLE-BOWEL-SYNDROME; GUT
   MICROBIOTA; METABOLIC SYNDROME; DOUBLE-BLIND; RECURRENT; DYSBIOSIS;
   FROZEN; NAFLD; PLACEBO
AB Numerous factors are involved in the pathogenesis of nonalcoholic fatty liver disease (NAFLD), which are responsible for its development and progression as an independent entity, but also thanks to their simultaneous action. This is explained by the hypothesis of multiple parallel hits. These factors are insulin resistance, lipid metabolism alteration, oxidative stress, endoplasmic reticulum stress, inflammatory cytokine liberation, gut microbiota dysbiosis or gut-liver axis activation. This is a systematic review which has an aim to show the connection between intestinal microbiota and the role of its disbalance in the development of NAFLD. The gut microbiota is made from a wide spectrum of microorganisms that has a systemic impact on human health, with a well-documented role in digestion, energy metabolism, the stimulation of the immune system, synthesis of essential nutrients, etc. It has been shown that dysbiosis is associated with all three stages of chronic liver disease. Thus, the modulation of the gut microbiota has attracted research interest as a novel therapeutic approach for the management of NAFLD patients. The modification of microbiota can be achieved by substantial diet modification and the application of probiotics or prebiotics, while the most radical effects are observed by fecal microbiota transplantation (FMT). Given the results of FMT in the context of metabolic syndrome (MetS) and NAFLD in animal models and scarce pilot studies on humans, FMT seems to be a promising treatment option that could reverse intestinal dysbiosis and thereby influence the course of NAFLD.
C1 [Hauser, Goran; Krznaric-Zrnic, Irena; Mikolasevic, Ivana] Clin Hosp Ctr Rijeka, Dept Gastroenterol, Rijeka 51000, Croatia.
   [Hauser, Goran; Benjak Horvat, Indira; Aljinovic-Vucic, Vedrana; Mikolasevic, Ivana] Univ Rijeka, Fac Med, Rijeka 51000, Croatia.
   [Benjak Horvat, Indira] Cty Hosp Varazdin, Dept Neurol, Varazhdin, Croatia.
   [Rajilic-Stojanovic, Mirjana] Univ Belgrade, Fac Technol & Met, Dept Biochem Engn & Biotechnol, Belgrade 11000, Serbia.
   [Kukla, Michail] Jagiellonian Univ, Med Coll, Dept Internal Med & Geriatr, PL-31121 Krakow, Poland.
   [Kukla, Michail] Univ Hosp Cracow, Dept Endoscopy, Krakow, Poland.
   [Kukla, Michail] Gromkowski Reg Specialist Hosp, Infect Dis Ward 1, 5 Koszarowa St, PL-50149 Wroclaw, Poland.
   [Aljinovic-Vucic, Vedrana] Jadran Galenski Lab Dd, Med Affairs Dept, Rijeka 51000, Croatia.
C3 University of Rijeka; University of Rijeka; University of Belgrade;
   Jagiellonian University; Collegium Medicum Jagiellonian University
RP Horvat, IB (corresponding author), Univ Rijeka, Fac Med, Rijeka 51000, Croatia.; Horvat, IB (corresponding author), Cty Hosp Varazdin, Dept Neurol, Varazhdin, Croatia.
EM goran.hauser@uniri.hr; indirabenjak@gmail.com; rajilic78@yahoo.com;
   ikrznariczrnic@yahoo.co.uk; kuklamich@poczta.onet.pl;
   vedrana.aljinovic@gmail.com; ivana.mikolasevic@uniri.hr
RI Zrnic, Irena/U-5347-2018; Benjak Horvat, Indira/AFL-8073-2022;
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NR 153
TC 0
Z9 0
U1 0
U2 0
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2227-9059
J9 BIOMEDICINES
JI Biomedicines
PD MAR 23
PY 2025
VL 13
IS 4
AR 779
DI 10.3390/biomedicines13040779
PG 27
WC Biochemistry & Molecular Biology; Medicine, Research & Experimental;
   Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Research & Experimental Medicine;
   Pharmacology & Pharmacy
GA 1ZI8P
UT WOS:001477243100001
PM 40299326
OA gold
DA 2025-06-11
ER

PT J
AU Bahçeci, E
   Kaya, C
   Karakas, S
   Yildiz, S
   Hosgören, M
   Ekin, M
AF Bahceci, Ece
   Kaya, Cihan
   Karakas, Sema
   Yildiz, Sukru
   Hosgoren, Murat
   Ekin, Murat
TI Serum X-box-binding protein 1 levels in PCOS patients
SO GYNECOLOGICAL ENDOCRINOLOGY
LA English
DT Article
DE Polycystic ovary syndrome; X-box protein 1; ER stress; insulin
   resistance
ID POLYCYSTIC-OVARY-SYNDROME; ENDOPLASMIC-RETICULUM STRESS; UNFOLDED
   PROTEIN; INSULIN; OBESITY; IRE1-ALPHA-XBP1; CONTRIBUTES; ACTIVATION;
   GRANULOSA; CELLS
AB Objective X-box binding protein-1 (XBP1) is a possible indicator of metabolic syndrome and diabetes. This study aimed to evaluate the relationship between serum XBP1 levels and polycystic ovary syndrome (PCOS). Method A prospective observational study was conducted with 88 patients. The first group was defined as the control group with ovulatory and normal-BMI patients (n = 28). The second group comprised of nonobese PCOS patients (n = 30). The third group included overweight/obese patients with PCOS (n = 30). Fasting plasma glucose, serum lipids, follicle stimulating hormone, luteinizing hormone, total testosterone, dehydroepiandrosterone and XBP1 levels l were evaluated in all groups. Results There was a significant difference in XBP1 levels between the study groups, and higher levels were observed both in the nonobese and obese PCOS groups than in the healthy controls (p < .001). The median level of XBP1 was 73.7 pg/ml in the control group, 114.11 pg/ml in the nonobese PCOS group, and 151.61 pg/ml in the overweight/obese PCOS group. A cutoff level of XBP1 at 95.79 pg/ml level was determined with a significant AUC (area under the curve) level of 99% and high specificity and sensitivity rates to predict PCOS. Also, a significant positive correlation was observed between XBP1 levels and BMI, waist circumference, fasting plasma glucose and triglyceride levels (p < .05). Conclusions XBP1 levels were significantly higher in PCOS patients, particularly in overweight/obese PCOS patients, than in the controls. Also, the parameters associated with metabolic syndrome were related to XBP1 levels.
C1 [Bahceci, Ece; Kaya, Cihan; Karakas, Sema; Yildiz, Sukru; Hosgoren, Murat; Ekin, Murat] Univ Hlth Sci, Obstet & Gynecol Clin, Dr Sadi Konuk Educ & Res Hosp, Istanbul, Turkey.
C3 University of Health Sciences Turkey
RP Bahçeci, E (corresponding author), Tevfik Saglam St 11, Istanbul, Turkey.
EM ecebahceci@yahoo.com
RI Yıldız, Şükrü/ABI-1553-2020; EKİN, MURAT/G-4282-2013; Kaya,
   Cihan/F-8883-2013
OI ekin, murat/0000-0002-4525-5125; Hosgoren, Murat/0000-0002-3714-4062;
   Karakas, Sema/0000-0002-2795-4766; Kaya, Cihan/0000-0003-4175-7694;
   Yildiz, Sukru/0000-0003-1490-365X
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NR 30
TC 10
Z9 10
U1 0
U2 6
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0951-3590
EI 1473-0766
J9 GYNECOL ENDOCRINOL
JI Gynecol. Endocrinol.
PD OCT 3
PY 2021
VL 37
IS 10
BP 920
EP 924
DI 10.1080/09513590.2021.1942449
EA JUN 2021
PG 5
WC Endocrinology & Metabolism; Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Obstetrics & Gynecology
GA UZ3IW
UT WOS:000664902700001
PM 34160344
DA 2025-06-11
ER

PT J
AU Ferreira, NS
   Tostes, RC
   Paradis, P
   Schiffrin, EL
AF Ferreira, Nathanne S.
   Tostes, Rita C.
   Paradis, Pierre
   Schiffrin, Ernesto L.
TI Aldosterone, Inflammation, Immune System, and Hypertension
SO AMERICAN JOURNAL OF HYPERTENSION
LA English
DT Review
DE adaptive immune response; lymphocytes; blood pressure; dendritic cells;
   hypertension; inflammation; innate immune response; mineralocorticoid
   receptor; monocytes/macrophages
ID GELATINASE-ASSOCIATED LIPOCALIN; VASCULAR ENDOTHELIAL-CELLS; II-INDUCED
   HYPERTENSION; ANGIOTENSIN-II; T-CELLS; OXIDATIVE STRESS; CARDIAC
   FIBROSIS; BLOOD-PRESSURE; NLRP3 INFLAMMASOME; DIABETES-MELLITUS
AB Aldosterone is a mineralocorticoid hormone that controls body fluid and electrolyte balance. Excess aldosterone is associated with cardiovascular and metabolic diseases. Inflammation plays a critical role on vascular damage promoted by aldosterone and aggravates vascular abnormalities, including endothelial dysfunction, vascular remodeling, fibrosis and oxidative stress, and other manifestations of end-organ damage that are associated with hypertension, other forms of cardiovascular disease, and diabetes mellitus and the metabolic syndrome. Over the past few years, many studies have consistently shown that aldosterone activates cells of the innate and adaptive immune systems. Macrophages and T cells accumulate in the kidneys, heart, and vasculature in response to aldosterone, and infiltration of immune cells contributes to end-organ damage in cardiovascular and metabolic diseases. Aldosterone activates various subsets of innate immune cells such as dendritic cells and monocytes/macrophages, as well as adaptive immune cells such as T lymphocytes, and, by activation of mineralocorticoid receptors stimulates proinflammatory transcription factors and the production of adhesion molecules and inflammatory cytokines and chemokines. This review will briefly highlight some of the studies on the involvement of aldosterone in activation of innate and adaptive immune cells and its impact on the cardiovascular system. Since aldosterone plays a key role in many cardiovascular and metabolic diseases, these data will open up promising perspectives for the identification of novel biomarkers and therapeutic targets for prevention and treatment of diseases associated with increased levels of aldosterone, such as arterial hypertension, obesity, the metabolic syndrome, and heart failure.
   [GRAPHICS]
   .
C1 [Ferreira, Nathanne S.; Paradis, Pierre; Schiffrin, Ernesto L.] McGill Univ, Sir Mortimer B Davis Jewish Gen Hosp, Lady Davis Inst Med Res, Hypertens & Vasc Res Unit, Montreal, PQ, Canada.
   [Tostes, Rita C.] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Pharmacol, Ribeirao Preto, SP, Brazil.
   [Schiffrin, Ernesto L.] McGill Univ, Sir Mortimer B Davis Jewish Gen Hosp, Dept Med, Montreal, PQ, Canada.
C3 Lady Davis Institute; Jewish General Hospital - Montreal; McGill
   University; Universidade de Sao Paulo; McGill University; Jewish General
   Hospital - Montreal
RP Schiffrin, EL (corresponding author), McGill Univ, Sir Mortimer B Davis Jewish Gen Hosp, Lady Davis Inst Med Res, Hypertens & Vasc Res Unit, Montreal, PQ, Canada.; Schiffrin, EL (corresponding author), McGill Univ, Sir Mortimer B Davis Jewish Gen Hosp, Dept Med, Montreal, PQ, Canada.
EM ernesto.schiffrin@mcgill.ca
RI Schiffrin, Ernesto/AAB-9061-2019; Tostes, Rita/C-1025-2012
OI Schiffrin, Ernesto/0000-0002-4502-2823; Paradis,
   Pierre/0000-0002-5692-1891
FU Canadian Institutes of Health Research (CIHR) [102606, 123465]; Canadian
   Institutes of Health Research First Pilot Foundation, a Tier 1 Canada
   Research Chair (CRC) on Hypertension and Vascular Research by the Canada
   Research Chairs/CIHR Program [143348]; Canada Fund for Innovation; Sao
   Paulo Research Foundation (FAPESP) [2013/08216-2]; Fundacao de Amparo a
   Pesquisa do Estado de Sao Paulo (FAPESP) [13/08216-2] Funding Source:
   FAPESP
FX The work of NSF, PP, and ELS was supported by Canadian Institutes of
   Health Research (CIHR) grants 102606 and 123465, and Canadian Institutes
   of Health Research First Pilot Foundation grant 143348, a Tier 1 Canada
   Research Chair (CRC) on Hypertension and Vascular Research by the Canada
   Research Chairs/CIHR Program, and by the Canada Fund for Innovation, all
   to ELS. RT was supported by the Sao Paulo Research Foundation (FAPESP,
   grant no. 2013/08216-2 to the Center for Research in Inflammatory
   Diseases).
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NR 107
TC 155
Z9 161
U1 8
U2 80
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0895-7061
EI 1941-7225
J9 AM J HYPERTENS
JI Am. J. Hypertens.
PD JAN
PY 2021
VL 34
IS 1
BP 15
EP 27
DI 10.1093/ajh/hpaa137
PG 13
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA QY7EE
UT WOS:000630199200003
PM 32820797
OA Green Published, hybrid
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Saleem, U
   Khaleghi, M
   Morgenthaler, NG
   Bergmann, A
   Struck, J
   Mosley, TH
   Kullo, IJ
AF Saleem, Umer
   Khaleghi, Mahyar
   Morgenthaler, Nils G.
   Bergmann, Andreas
   Struck, Joachim
   Mosley, Thomas H., Jr.
   Kullo, Iftikhar J.
TI Plasma Carboxy-Terminal Provasopressin (Copeptin): A Novel Marker of
   Insulin Resistance and Metabolic Syndrome
SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Article
ID HOMEOSTASIS MODEL ASSESSMENT; PITUITARY-ADRENAL AXIS;
   ARGININE-VASOPRESSIN; NATRIURETIC PEPTIDE; PSYCHOSOCIAL STRESS;
   SECRETION; GLUCOSE; RECEPTORS; HYPERTENSION; STIMULATION
AB Context: Stress-mediated hypothalamic-pituitary-adrenal axis activation, regulated by arginine vasopressin (AVP), may have a role in the pathophysiology of metabolic syndrome (MetSyn).
   Objective: The objective of the study was to investigate whether plasma C-terminal provasopressin fragment (copeptin), a surrogate for circulating AVP, was associated with measures of insulin resistance and presence of MetSyn.
   Design, Setting, and Participants: This was a multicenter, community-based study, investigating novel biomarkers for vascular disease. Participants included 1293 African-Americans (AA) (64 +/- 9 yr) and 1197 non-Hispanic whites (NHW) (59 +/- 10 yr) belonging to hypertensive sibships.
   Main Outcome Measures: Plasma copeptin levels were measured by an immunoluminometric assay. MetSyn was defined per Adult Treatment Panel III criteria. Generalized estimating equations were used to assess whether plasma copeptin was associated with measures of insulin resistance and MetSyn.
   Results: The prevalence of MetSyn was 50% in AA and 49% in NHW. In each group, after adjustment for age and sex, plasma copeptin levels significantly correlated with body mass index, fasting plasma glucose and insulin, homeostasis model assessment of insulin resistance, triglycerides, and (inversely) high-density lipoprotein cholesterol (P < 0.05 for each variable). In multivariable logistic regression models that adjusted for age, sex, smoking, statin use, serum creatinine, education, physical activity, and diuretic use, plasma copeptin levels in the highest quartile were associated with an increased odds ratio of having MetSyn compared with bottom quartile: odds ratio (95% confidence interval) in AA, 2.07 (1.45-2.95); in NHW, 1.74 (1.21-2.5).
   Conclusions: Our findings indicate a novel cross-sectional association between plasma copeptin and measures of insulin resistance and MetSyn. (J Clin Endocrinol Metab 94: 2558-2564, 2009)
C1 [Saleem, Umer; Khaleghi, Mahyar; Kullo, Iftikhar J.] Mayo Clin, Div Cardiovasc Dis, Rochester, MN 55905 USA.
   [Morgenthaler, Nils G.; Bergmann, Andreas; Struck, Joachim] Ctr Biotechnol, Dept BRAHMS AG, D-16761 Hennigsdorf, Germany.
   [Mosley, Thomas H., Jr.] Univ Mississippi, Med Ctr, Dept Geriatr Med, Jackson, MS 39216 USA.
C3 Mayo Clinic; Thermo Fisher Scientific; Brahms AG; University of
   Mississippi; University of Mississippi Medical Center
RP Kullo, IJ (corresponding author), Mayo Clin, Div Cardiovasc Dis, 200 1st St SW, Rochester, MN 55905 USA.
EM kullo.iftikhar@mayo.edu
FU National Institutes of Health [HL-81331]
FX This work was supported by Grant HL-81331 from the National Institutes
   of Health.
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NR 40
TC 135
Z9 146
U1 0
U2 5
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0021-972X
EI 1945-7197
J9 J CLIN ENDOCR METAB
JI J. Clin. Endocrinol. Metab.
PD JUL
PY 2009
VL 94
IS 7
BP 2558
EP 2564
DI 10.1210/jc.2008-2278
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 467UB
UT WOS:000267767500054
PM 19366852
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Barbagallo, I
   Li Volti, G
   Sorrenti, V
   Di Giacomo, C
   Acquaviva, R
   Raffaele, M
   Galvano, F
   Vanella, L
AF Barbagallo, Ignazio
   Li Volti, Giovanni
   Sorrenti, Valeria
   Di Giacomo, Claudia
   Acquaviva, Rosaria
   Raffaele, Marco
   Galvano, Fabio
   Vanella, Luca
TI Caffeic Acid Phenethyl Ester Restores Adipocyte Gene Profile Expression
   Following Lipopolysaccharide Treatment
SO LETTERS IN DRUG DESIGN & DISCOVERY
LA English
DT Article
DE Adipocyte; heme oxygenase; inflammation; caffeic acid phenethyl ester;
   antioxidants
ID NECROSIS-FACTOR-ALPHA; ADIPOSE-TISSUE; HEME OXYGENASE-1; OXIDATIVE
   STRESS; UP-REGULATION; SUPPRESSES; OBESITY; DIFFERENTIATION; SILIBININ;
   ADIPOGENESIS
AB Background: Obesity alters endocrine and metabolic function of the adipose tissue leading to an increased release of fatty acids, adipokynes and pro-inflammatory molecules which in turn lead to complications related to the onset of metabolic syndrome.
   Methods: To this regard, natural antioxidants have been found to have anti-inflammatory and protective action in cardiovascular diseases, diabetes mellitus and obesity. Caffeic acid phenethyl ester (CAPE) is synthesized in a variety of plants and is one of the main components of propolis. CAPE inhibits oxidative stress and showed beneficial effects under various experimental conditions.
   Aims: The aim of the study was to evaluate the effect of CAPE on adipocyte function after an inflammatory stimulus with lipopolysaccharide (LPS) (1 ng/ml for 6h).
   Results: Our data showed that LPS caused an increased expression of proinflammatory interleukin IL-6 and a lipolytic effect on the adipocytes. CAPE treatment inhibited LPS effects through a significant decrease of IL-6 and a concomitant increase of peroxisome proliferator-activated receptor gamma (PPAR.), CCAAT/Enhancer Binding Protein alpha (CEBP alpha), fatty acid synthase (FAS), fatty acid binding protein 4 (FABP4), diacylglycerol O-acyltransferase 1 (DGAT1) and transcription factor sterol regulatory element binding protein-1c (SREBP-1c). Moreover, the increased levels of adiponectin, heme oxygenase-1, nuclear factor (erythroid-derived 2)-like 2 (Nrf2), peroxisome proliferator- activated receptor alpha (PPARa) and Sirtuin-1 suggest that CAPE administration restores adipocyte function following inflammation.
   Conclusion: In conclusion, the use of this metabolite such as a food supplement may represent a possible strategy for the treatment of conditions related to metabolic syndrome.
C1 [Barbagallo, Ignazio; Sorrenti, Valeria; Di Giacomo, Claudia; Acquaviva, Rosaria; Raffaele, Marco; Vanella, Luca] Univ Catania, Dept Drug Sci, Viale Andrea Doria,6, I-95125 Catania, Italy.
   [Li Volti, Giovanni; Galvano, Fabio] Univ Catania, Dept Biomed & Biotechnol Sci, Catania, Italy.
C3 University of Catania; University of Catania
RP Barbagallo, I (corresponding author), Univ Catania, Dept Drug Sci, Viale Andrea Doria,6, I-95125 Catania, Italy.
EM ignazio.barbagallo@unict.it
RI Volti, Giovanni/A-2435-2008; Raffaele, Marco/AAQ-2895-2020; Vanella,
   Luca/J-7354-2016; Galvano, Fabio/JSL-7451-2023; Acquaviva,
   Rosaria/A-6750-2018; Galvano, Fabio/F-8122-2010
OI Di Giacomo, Claudia/0000-0002-2665-0007; Li Volti,
   Giovanni/0000-0002-8678-2183; Galvano, Fabio/0000-0003-0644-0755;
   Barbagallo, Ignazio/0000-0002-7761-0662
FU University of Catania
FX This study was supported by FIR2014 program from the University of
   Catania.
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NR 44
TC 4
Z9 4
U1 0
U2 8
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1570-1808
EI 1875-628X
J9 LETT DRUG DES DISCOV
JI Lett. Drug Des. Discov.
PY 2017
VL 14
IS 4
BP 481
EP 487
DI 10.2174/1570180813666160901124707
PG 7
WC Chemistry, Medicinal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA EN0DA
UT WOS:000395679300010
DA 2025-06-11
ER

PT J
AU Green, E
   Fairchild, JK
   Kinoshita, LM
   Noda, A
   Yesavage, J
AF Green, Erin
   Fairchild, J. Kaci
   Kinoshita, Lisa M.
   Noda, Art
   Yesavage, Jerome
TI Effects of Posttraumatic Stress Disorder and Metabolic Syndrome on
   Cognitive Aging in Veterans
SO GERONTOLOGIST
LA English
DT Article
DE Veterans; Cognition; Obesity; Memory; Metabolic Sydrome; PTSD
ID CARDIOVASCULAR RISK-FACTORS; ADMINISTERED PTSD SCALE; ISCHEMIC
   BRAIN-LESIONS; LOW BLOOD-PRESSURE; LATER LIFE; KUNGSHOLMEN PROJECT;
   ALZHEIMERS-DISEASE; OLDER VETERANS; DEMENTIA; PEOPLE
AB Purpose of the Study: With the influx of veterans entering older adulthood, it is increasingly important to understand risk factors for cognitive decline. Posttraumatic stress disorder (PTSD) and the metabolic syndrome (MetS) are highly prevalent in older veterans. Although both increase risk for cognitive decline and often co-occur, it is unclear how they may interact to negatively impact cognition. The aim of this cross-sectional study was to investigate associations among PTSD, MetS, and cognitive function in older veterans. We hypothesized that co-occurring PTSD and MetS would be associated with worse cognitive performance than seen in either illness alone.
   Design and Methods: Participants completed cognitive testing to assess processing speed, verbal memory, and executive function. Data from 204 male veterans aged 55-89 were analyzed with the use of hierarchical multiple regression models.
   Results: Veterans with MetS demonstrated poorer performance on tasks of executive function (response inhibition and cognitive set shifting) and immediate verbal memory regardless of PTSD status. There was an interaction between MetS and PTSD on delayed verbal memory, suggesting that the negative impact of MetS on verbal memory was only significant for veterans not classified as having PTSD.
   Implications: This is the first study to examine the impact of comorbid PTSD and MetS on cognition. The results suggest that MetS is associated with poorer verbal learning and executive functioning independent of PTSD. We discuss the necessity of monitoring cerebrovascular risk factors and providing early behavioral and/or pharmaceutical interventions to lessen the risk of cognitive decline in older age.
C1 [Green, Erin; Fairchild, J. Kaci; Kinoshita, Lisa M.; Yesavage, Jerome] VA Palo Alto Hlth Care Syst, Dept Vet Affairs, Palo Alto, CA USA.
   [Green, Erin; Fairchild, J. Kaci; Kinoshita, Lisa M.; Noda, Art; Yesavage, Jerome] Stanford Univ, Sch Med, Dept Psychiat & Behav Sci, Stanford, CA 94305 USA.
C3 US Department of Veterans Affairs; Veterans Health Administration (VHA);
   VA Palo Alto Health Care System; Stanford University
RP Yesavage, J (corresponding author), Stanford Univ, Sch Med, Dept Psychiat & Behav Sci, Stanford, CA 94305 USA.
EM yesavage@stanford.edu
FU Medical Research Service of the Department of Veterans Affairs, VA Merit
   Review Grant; Sierra-Pacific Mental Illness Research, Education, and
   Clinical Center (MIRECC); Advanced Fellowship in Mental Illness and
   Treatment at the Sierra-Pacific MIRECC
FX This research was supported by the Medical Research Service of the
   Department of Veterans Affairs, VA Merit Review Grant and the
   Sierra-Pacific Mental Illness Research, Education, and Clinical Center
   (MIRECC). E. Green is supported by the Advanced Fellowship in Mental
   Illness and Treatment at the Sierra-Pacific MIRECC.
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NR 54
TC 24
Z9 26
U1 0
U2 15
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0016-9013
EI 1758-5341
J9 GERONTOLOGIST
JI Gerontologist
PD FEB
PY 2016
VL 56
IS 1
SI SI
BP 72
EP 81
DI 10.1093/geront/gnv040
PG 10
WC Gerontology
WE Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA DJ5AW
UT WOS:000374220200009
PM 26220415
DA 2025-06-11
ER

PT J
AU Andrés-Blasco, I
   Herrero-Cervera, A
   Vinué, A
   Martínez-Hervás, S
   Piqueras, L
   Sanz, MJ
   Burks, DJ
   González-Navarro, H
AF Andres-Blasco, Irene
   Herrero-Cervera, Andrea
   Vinue, Angela
   Martinez-Hervas, Sergio
   Piqueras, Laura
   Jesus Sanz, Maria
   Jane Burks, Deborah
   Gonzalez-Navarro, Herminia
TI Hepatic lipase deficiency produces glucose intolerance, inflammation and
   hepatic steatosis
SO JOURNAL OF ENDOCRINOLOGY
LA English
DT Article
DE glucose intolerance; steatosis; inflammation; lipase
ID FATTY LIVER-DISEASE; INSULIN-RESISTANCE; TRIGLYCERIDE LIPASE;
   LIPOPROTEIN-LIPASE; AGGRAVATES ATHEROSCLEROSIS; METABOLIC SYNDROME;
   DIABETES-MELLITUS; SIGNALING PATHWAY; HERITAGE FAMILY; BLOOD-LIPIDS
AB Metabolic syndrome and type 2 diabetes mellitus constitute a major problem to global health, and their incidence is increasing at an alarming rate. Non-alcoholic fatty liver disease, which affects up to 90% of obese people and nearly 70% of the overweight, is commonly associated with MetS characteristics such as obesity, insulin resistance, hypertension and dyslipidemia. In the present study, we demonstrate that hepatic lipase (HL)-inactivation in mice fed with a high-fat, high-cholesterol diet produced dyslipidemia including hypercholesterolemia, hypertriglyceridemia and increased non-esterified fatty acid levels. These changes were accompanied by glucose intolerance, pancreatic and hepatic inflammation and steatosis. In addition, compared with WT mice, HL-/- mice exhibited enhanced circulating MCP1 levels, monocytosis and higher percentage of CD4CTh17C cells. Consistent with increased inflammation, livers from HL-/- mice had augmented activation of the stress SAPK/JNK- and p38-pathways compared with the activation levels of the kinases in livers from WT mice. Analysis of HL-/- and WT mice fed regular chow diet showed dyslipidemia and glucose intolerance in HL-/- mice without any other changes in inflammation or hepatic steatosis. Altogether, these results indicate that dyslipidemia induced by HL-deficiency in combination with a high-fat, high-cholesterol diet promotes hepatic steatosis and inflammation in mice which are, at least in part, mediated by the activation of the stress SAPK/JNK- and p38-pathways. Future studies are warranted to asses the viability of therapeutic strategies based on the modulation of these kinases to reduce hepatic steatosis associated to lipase dysfunction.
C1 [Andres-Blasco, Irene; Herrero-Cervera, Andrea; Vinue, Angela; Martinez-Hervas, Sergio; Piqueras, Laura; Jesus Sanz, Maria; Gonzalez-Navarro, Herminia] Inst Hlth Res INCLIVA, Valencia 46010, Spain.
   [Martinez-Hervas, Sergio] Univ Valencia, Endocrinol & Nutr Dept, Clin Hosp, Valencia, Spain.
   [Martinez-Hervas, Sergio] Univ Valencia, Dept Med, Valencia, Spain.
   [Martinez-Hervas, Sergio; Jane Burks, Deborah; Gonzalez-Navarro, Herminia] CIBER Diabet & Enfermedades Metab Asociadas CIBER, Valencia, Spain.
   [Jesus Sanz, Maria] Univ Valencia, Dept Farmacol, Valencia, Spain.
   [Jane Burks, Deborah] Ctr Invest Principe Felipe, Valencia, Spain.
C3 University of Valencia; University of Valencia; CIBER - Centro de
   Investigacion Biomedica en Red; CIBERES; University of Valencia; Prince
   Felipe Research Center
RP González-Navarro, H (corresponding author), Inst Hlth Res INCLIVA, Ave Menendez Pelayo 4, Valencia 46010, Spain.
EM gonzaleh@uv.es
RI Sanz, Maria/A-6099-2016; PIQUERAS, LAURA/LXW-1265-2024; Martinez Hervas,
   Sergio/K-2829-2014
OI Martinez Hervas, Sergio/0000-0002-6775-2034; Gonzalez-Navarro,
   Herminia/0000-0001-6883-3808; Sanz, Maria Jesus/0000-0002-8885-294X;
   PIQUERAS, LAURA/0000-0001-8010-5168; , Andrea/0000-0001-6490-6504
FU Carlos III Health Institute [FIS: PI-CP10/00555, PI13/00834]; Spanish
   Ministry of Economy and Competitiveness [SAF2011-23777]; European
   Regional Development Fund (FEDER); Generalitat Valenciana
   [GVACOMP2014-006, PROMETEO II/2013/014]; 'Miguel Servet' program
   [CP10/00555]; Proyecto Paula; CIBERDEM, a Carlos III Health Institute
   initiative
FX This study was supported by grants from the Carlos III Health Institute
   (FIS: PI-CP10/00555 and PI13/00834 to HG-N) from the Spanish Ministry of
   Economy and Competitiveness (SAF2011-23777 to M J S) and from the
   European Regional Development Fund (FEDER) and research grants from
   Generalitat Valenciana (GVACOMP2014-006 and PROMETEO II/2013/014). H G-N
   is an investigator from the 'Miguel Servet' program (CP10/00555). I A-B
   and A V received salary support from Proyecto Paula. This work was
   supported by the CIBERDEM, a Carlos III Health Institute initiative.
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NR 52
TC 28
Z9 30
U1 1
U2 18
PU BIOSCIENTIFICA LTD
PI BRISTOL
PA EURO HOUSE, 22 APEX COURT WOODLANDS, BRADLEY STOKE, BRISTOL BS32 4JT,
   ENGLAND
SN 0022-0795
EI 1479-6805
J9 J ENDOCRINOL
JI J. Endocrinol.
PD DEC
PY 2015
VL 227
IS 3
BP 179
EP 191
DI 10.1530/JOE-15-0219
PG 13
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA CW5LA
UT WOS:000365035700008
PM 26423094
OA Bronze
DA 2025-06-11
ER

PT J
AU Bourgoin, F
   Bachelard, H
   Badeau, M
   Larivière, R
   Nadeau, A
   Pitre, M
AF Bourgoin, Frederic
   Bachelard, Helene
   Badeau, Mylene
   Lariviere, Richard
   Nadeau, Andre
   Pitre, Maryse
TI Effects of tempol on endothelial and vascular dysfunctions and insulin
   resistance induced by a high-fat high-sucrose diet in the rat
SO CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
LA English
DT Article
DE insulin resistance; oxidative stress; cardiometabolic complications;
   endothelial dysfunction; HFHS diet; tempol; metabolic syndrome
ID ALPHA-LIPOIC ACID; GLUCOSE-TRANSPORT ACTIVITY; NITRIC-OXIDE SYNTHESIS;
   MUSCLE BLOOD-FLOW; SKELETAL-MUSCLE; METABOLIC SYNDROME;
   HEMODYNAMIC-RESPONSES; IN-VIVO; SYMPATHETIC HYPERACTIVITY; MICROVASCULAR
   RECRUITMENT
AB We investigated the effects of treatment with tempol (an antioxidant) on vascular and metabolic dysfunction induced by a high-fat high-sucrose (HFHS) diet. Rats were randomized to receive an HFHS or chow diet with or without tempol treatment (1.5 mmol.(kg body mass)(-1).day(-1)) for 4 weeks. Blood pressure, heart rate, and blood flow were measured in the rats by using intravascular catheters and Doppler flow probes. Insulin sensitivity and vascular responses to insulin were assessed during a euglycemic-hyperinsulinemic clamp. In-vitro studies were performed to evaluate vascular reactivity and endothelial and inducible nitric oxide synthase (eNOS; iNOS) expression in vascular and muscle tissues. Endothelin, nitrotyrosine, and NAD(P)H oxidase expressions were determined in vascular tissues, and glucose transport activity and glucose transporter 4 (GLUT4) expression were examined in muscles. Tempol treatment was found to prevent alterations in insulin sensitivity, glucose transport activity, GLUT4 expression, and vascular reactivity, and to prevent increases in plasma insulin, blood pressure, and heart rate noted in the untreated HFHS-fed rats. These were associated with increased levels of eNOS expression in vascular and muscle tissues, but reductions in nitrotyrosine, endothelin, NAD(P) H oxidase, and iNOS expressions. Therefore, oxidative stress induced by a relatively short-term HFHS diet could contribute to the early development of vascular and metabolic abnormalities in rats.
C1 [Bourgoin, Frederic; Bachelard, Helene; Badeau, Mylene; Nadeau, Andre; Pitre, Maryse] Univ Laval, Dept Med, CHUL, CHUQ Res Ctr, Quebec City, PQ G1V 4G2, Canada.
   [Lariviere, Richard] Univ Laval, Fac Med, Dept Med, CHUQ Res Ctr,Hotel Dieu Quebec, Quebec City, PQ G1V 4G2, Canada.
C3 Laval University; Laval University Hospital; Laval University; Laval
   University Hospital
RP Bachelard, H (corresponding author), Univ Laval, Dept Med, CHUL, CHUQ Res Ctr, Quebec City, PQ G1V 4G2, Canada.
EM helene.bachelard@crchul.ulaval.ca
FU Canadian Institutes of Health Research; Heart and Stroke Foundation of
   Quebec; Association Diabete Quebec
FX The authors wish to thank Marie Tremblay from Andre Nadeau's laboratory
   for her expert assistance for insulin and glucose plasma analysis. We
   thank Genevieve Pilon and Patrice Dallaire from Andre Marette's
   laboratory for their professional support and judicious advice
   concerning Western blot analysis. We also thank Nadia Chbinou from
   Richard Lariviere's laboratory for her experimental support in confocal
   microscopy method. This work was supported by grants to Dr. H. Bachelard
   from the Canadian Institutes of Health Research and the Heart and Stroke
   Foundation of Quebec. F. Bourgoin was supported by a studentship from
   the Association Diabete Quebec.
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NR 85
TC 12
Z9 13
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U2 9
PU CANADIAN SCIENCE PUBLISHING
PI OTTAWA
PA 65 AURIGA DR, SUITE 203, OTTAWA, ON K2E 7W6, CANADA
SN 0008-4212
EI 1205-7541
J9 CAN J PHYSIOL PHARM
JI Can. J. Physiol. Pharmacol.
PD JUL
PY 2013
VL 91
IS 7
BP 547
EP 561
DI 10.1139/cjpp-2012-0273
PG 15
WC Pharmacology & Pharmacy; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Physiology
GA 176UO
UT WOS:000321331300006
PM 23826653
DA 2025-06-11
ER

PT J
AU Nawrocka-Rutkowska, J
   Szydlowska, I
   Jakubowska, K
   Olszewska, M
   Chlubek, D
   Szczuko, M
   Starczewski, A
AF Nawrocka-Rutkowska, Jolanta
   Szydlowska, Iwona
   Jakubowska, Katarzyna
   Olszewska, Maria
   Chlubek, Dariusz
   Szczuko, Malgorzata
   Starczewski, Andrzej
TI The Role of Oxidative Stress in the Risk of Cardiovascular Disease and
   Identification of Risk Factors Using AIP and Castelli Atherogenicity
   Indicators in Patients with PCOS
SO BIOMEDICINES
LA English
DT Article
DE PCOS; oxidative stress; atherogenicity indicators; AIP; Castelli index;
   cardiovascular disease
ID POLYCYSTIC-OVARY-SYNDROME; INSULIN-RESISTANCE; DIAGNOSTIC-CRITERIA;
   METABOLIC SYNDROME; TNF-ALPHA; IGF-I; PATHWAYS; OBESITY; WOMEN;
   HYPERANDROGENISM
AB Polycystic ovarian syndrome (PCOS) is one of the most common endocrinopathies in females of reproductive age and may affect 5-14% of women. In women with PCO syndrome, metabolic disorders such as insulin resistance, hyperinsulinemia, obesity, diabetes mellitus, and other elements of metabolic syndrome may occur. Patients with PCOS often have overweight and obesity, especially abdominal obesity, which is one of the risk factors for developing atherosclerosis. The atherogenicity indicators of AIP (atherogenic index of plasma) and Castelli's index are used to assess the risk of developing atherosclerosis. Studies have shown an increase in the concentration and activity of oxidative stress markers in patients with PCOS compared to women without the disease. The aim of the present study was to evaluate oxidative stress parameters in patients with PCOS in relation to insulin resistance, BMI, and hyperandrogenemia and to correlate them with cardiovascular risk parameters. Conclusions: The severity of oxidative stress in women with PCOS correlates with exposure to cardiovascular diseases. The assessment of additional cardiovascular disease (CVD) parameters is useful in identifying the risk groups for cardiometabolic disease among PCOS patients. When additional risk factors such as hyperandrogenism and insulin resistance (IR) are present in patients with PCOS, it is reasonable to include preventive examinations early. It is also important to evaluate lipidograms, which will make it possible to determine indicators of atherogenicity. Patients with PCOS and IR are at particular risk for cardiovascular complications. PCOS should be considered an important risk factor for CVD, which occurs independently of the occurrence of obesity. This factor is related to the important role of insulin resistance, which occurs independently of obesity. Atherogenic factors (AIP and Castelli index) are useful additional parameters to assess the risk of cardiometabolic disease in PCOS patients, especially among groups with insulin resistance. The early detection of risk factors should be an integral part of the care of PCOS patients. In laboratory studies of women with PCOS, TG, TChol, HDL-c and LDL-c levels, and glutathione peroxidase (GPx) activity were most clearly correlated with exposure to cardiovascular disease.
C1 [Nawrocka-Rutkowska, Jolanta; Szydlowska, Iwona; Starczewski, Andrzej] Pomeranian Med Univ, Dept Gynecol Endocrinol & Gynecol Oncol, Unii Lubelskiej St 1, PL-71252 Szczecin, Poland.
   [Jakubowska, Katarzyna; Olszewska, Maria; Chlubek, Dariusz] Pomeranian Med Univ, Dept Biochem & Med Chem, Powstancow Wielkopolskich St 72, PL-70111 Szczecin, Poland.
   [Szczuko, Malgorzata] Pomeranian Med Univ, Dept Human Nutr & Metabol, PL-71460 Szczecin, Poland.
C3 Pomeranian Medical University; Pomeranian Medical University; Pomeranian
   Medical University
RP Nawrocka-Rutkowska, J (corresponding author), Pomeranian Med Univ, Dept Gynecol Endocrinol & Gynecol Oncol, Unii Lubelskiej St 1, PL-71252 Szczecin, Poland.
EM jolanta.nawrocka.rutkowska@pum.edu.pl; iwona.szydlowska@pum.edu.pl;
   katarzyna.jakubowska@pum.edu.pl; maria.olszewska@pum.edu.pl;
   dariusz.chlubek@pum.edu.pl; malgorzata.szczuko@pum.edu.pl;
   andrzejstarcz@o2.pl
RI Jakubowska, Katarzyna/B-2611-2016; Szydłowska, Iwona/AAA-6713-2022;
   Olszewska, Maria/N-7170-2014; Chlubek, Dariusz/J-6310-2014; Szczuko,
   Malgorzata/A-9501-2015
OI Nawrocka-Rutkowska, Jolanta/0000-0002-1631-152X; Chlubek,
   Dariusz/0000-0003-4497-4395; Szydlowska, Iwona/0000-0003-1518-8838;
   Szczuko, Malgorzata/0000-0001-9808-0624
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NR 55
TC 12
Z9 13
U1 1
U2 5
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2227-9059
J9 BIOMEDICINES
JI Biomedicines
PD JUL
PY 2022
VL 10
IS 7
AR 1700
DI 10.3390/biomedicines10071700
PG 14
WC Biochemistry & Molecular Biology; Medicine, Research & Experimental;
   Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Research & Experimental Medicine;
   Pharmacology & Pharmacy
GA 3J7YM
UT WOS:000833608800001
PM 35885005
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Jung, E
   Romero, R
   Yeo, L
   Gomez-Lopez, N
   Chaemsaithong, P
   Jaovisidha, A
   Gotsch, F
   Erez, O
AF Jung, Eunjung
   Romero, Roberto
   Yeo, Lami
   Gomez-Lopez, Nardhy
   Chaemsaithong, Piya
   Jaovisidha, Adithep
   Gotsch, Francesca
   Erez, Offer
TI The etiology of preeclampsia
SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
LA English
DT Review
DE angiotensin receptor II; atherosclerosis; autoantibodies; Ballantyne
   syndrome; body mass index; COVID-19; Cushing's syndrome; endothelial
   cell dysfunction; genetic incompatibility; gestational diabetes
   mellitus; hydatidiform mole; hydrops fetalis; hyperaldosteronism;
   hyperparathyroidism; hypertension; infection; inflammation; insulin
   resistance; intestinal dysbiosis; maternal antifetal rejection;
   metabolic syndrome; mirror syndrome; molar pregnancy; obesity; placental
   aging; placental ischemia; placental lesions of maternal vascular
   malperfusion; primipaternity; proteinuria; SARS-CoV-2; sleep-disordered
   breathing; sleep disorders; snoring; tolerance
ID EARLY-ONSET PREECLAMPSIA; FOR-GESTATIONAL-AGE; MATERNAL
   PLASMA-CONCENTRATIONS; PERIVILLOUS FIBRIN DEPOSITION; UTERINE
   PERFUSION-PRESSURE; VITAMIN-D SUPPLEMENTATION; ANTI-ANGIOGENIC FACTORS;
   NECROSIS-FACTOR-ALPHA; ACUTE ATHEROSIS; METABOLIC SYNDROME
AB Preeclampsia is one of the "great obstetrical syndromes" in which multiple and sometimes overlapping pathologic processes activate a common pathway consisting of endothelial cell activation, intravascular inflammation, and syncytiotrophoblast stress. This article reviews the potential etiologies of preeclampsia. The role of uteroplacental ischemia is well-established on the basis of a solid body of clinical and experimental evidence. A causal role for microorganisms has gained recognition through the realization that periodontal disease and maternal gut dysbiosis are linked to atherosclerosis, thus possibly to a subset of patients with preeclampsia. The recent reports indicating that SARS-CoV-2 infection might be causally linked to preeclampsia are reviewed along with the potential mechanisms involved. Particular etiologic factors, such as the breakdown of maternal-fetal immune tolerance (thought to account for the excess of preeclampsia in primipaternity and egg donation), may operate, in part, through uteroplacental ischemia, whereas other factors such as placental aging may operate largely through syncytiotrophoblast stress. This article also examines the association between gestational diabetes mellitus and maternal obesity with preeclampsia. The role of autoimmunity, fetal diseases, and endocrine disorders is discussed. A greater understanding of the etiologic factors of preeclampsia is essential to improve treatment and prevention.
C1 [Jung, Eunjung; Romero, Roberto; Yeo, Lami; Gomez-Lopez, Nardhy; Chaemsaithong, Piya; Gotsch, Francesca; Erez, Offer] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Perinatol Res Branch, Div Obstet & Maternal Fetal Med, Div Intramural Res,NIH,US Dept Hlth & Human Serv, Bethesda, MD 20892 USA.
   [Jung, Eunjung; Romero, Roberto; Yeo, Lami; Gomez-Lopez, Nardhy; Chaemsaithong, Piya; Gotsch, Francesca; Erez, Offer] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Perinatol Res Branch, Div Obstet & Maternal Fetal Med, Div Intramural Res,NIH,US Dept Hlth & Human Serv, Bethesda, MD 20892 USA.
   [Jung, Eunjung; Yeo, Lami; Gomez-Lopez, Nardhy; Chaemsaithong, Piya; Gotsch, Francesca; Erez, Offer] Wayne State Univ, Sch Med, Dept Obstet & Gynecol, Detroit, MI 48201 USA.
   [Romero, Roberto] Univ Michigan, Dept Obstet & Ginecol, Ann Arbor, MI 48109 USA.
   [Romero, Roberto] Michigan State Univ, Dept Epidemiol & Biostat, E Lansing, MI 48824 USA.
   [Romero, Roberto] Wayne State Univ, Ctr Mol Med & Genet, Detroit, MI 48202 USA.
   [Romero, Roberto] Detroit Med Ctr, Detroit, MI 48201 USA.
   [Gomez-Lopez, Nardhy] Wayne State Univ, Sch Med, Dept Biochem Microbiol & Immunol, Detroit, MI USA.
   [Chaemsaithong, Piya; Jaovisidha, Adithep] Mahidol Univ, Ramathibodi Hosp, Dept Obstet & Gynecol, Fac Med, Bangkok, Thailand.
   [Erez, Offer] HaEmek Med Ctr, Dept Obstet & Gynecol, Afula, Israel.
C3 National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver
   National Institute of Child Health & Human Development (NICHD); Division
   of Intramural Research (DIR); National Institutes of Health (NIH) - USA;
   NIH Eunice Kennedy Shriver National Institute of Child Health & Human
   Development (NICHD); Division of Intramural Research (DIR); Wayne State
   University; University of Michigan System; University of Michigan;
   Michigan State University; Wayne State University; Detroit Medical
   Center; Wayne State University; Mahidol University; Emek Medical Center
RP Romero, R (corresponding author), Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Perinatol Res Branch, Div Obstet & Maternal Fetal Med, Div Intramural Res,NIH,US Dept Hlth & Human Serv, Bethesda, MD 20892 USA.; Romero, R (corresponding author), Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Perinatol Res Branch, Div Obstet & Maternal Fetal Med, Div Intramural Res,NIH,US Dept Hlth & Human Serv, Bethesda, MD 20892 USA.; Romero, R (corresponding author), Univ Michigan, Dept Obstet & Ginecol, Ann Arbor, MI 48109 USA.; Romero, R (corresponding author), Michigan State Univ, Dept Epidemiol & Biostat, E Lansing, MI 48824 USA.; Romero, R (corresponding author), Wayne State Univ, Ctr Mol Med & Genet, Detroit, MI 48202 USA.; Romero, R (corresponding author), Detroit Med Ctr, Detroit, MI 48201 USA.
EM prbchiefstaff@med.wayne.edu
RI Romero, Roberto/JFJ-5209-2023; Erez, Offer/F-1466-2012; Romero,
   Roberto/A-5268-2019; Gomez-Lopez, Nardhy/R-7664-2016
OI Romero, Roberto/0000-0002-4448-5121; chaemsaithong,
   piya/0000-0003-1750-9834; Gomez-Lopez, Nardhy/0000-0002-3406-5262
FU Perinatology Research Branch, Division of Obstetrics and Maternal-Fetal
   Medicine, Division of Intramural Research, Eunice Kennedy Shriver
   National Institute of Child Health and Human Development, National
   Institutes of Health, US Department of Health and H; NICHD/NIH/DHHS
   [HHSN275201300006C]; Wayne State University Perinatal Initiative in
   Maternal, Perinatal and Child Health; Eunice Kennedy Shriver National
   Institute of Child Health and Human Development [ZIAHD002400] Funding
   Source: NIH RePORTER
FX This research was supported, in part, by the Perinatology Research
   Branch, Division of Obstetrics and Maternal-Fetal Medicine, Division of
   Intramural Research, Eunice Kennedy Shriver National Institute of Child
   Health and Human Development, National Institutes of Health, US
   Department of Health and Human Services (NICHD/NIH/DHHS); and, in part,
   with federal funds from NICHD/NIH/DHHS under contract number
   HHSN275201300006C. This research was also supported by the Wayne State
   University Perinatal Initiative in Maternal, Perinatal and Child Health
   (N.G.L.).
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NR 315
TC 252
Z9 267
U1 10
U2 80
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0002-9378
EI 1097-6868
J9 AM J OBSTET GYNECOL
JI Am. J. Obstet. Gynecol.
PD FEB
PY 2022
VL 226
IS 2
SU S
BP S844
EP S866
DI 10.1016/j.ajog.2021.11.1356
EA FEB 2022
PG 23
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA ZF5VZ
UT WOS:000759636700005
PM 35177222
OA Green Accepted
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Chan, PC
   Liao, MT
   Hsieh, PS
AF Chan, Pei-Chi
   Liao, Min-Tser
   Hsieh, Po-Shiuan
TI The Dualistic Effect of COX-2-Mediated Signaling in Obesity and Insulin
   Resistance
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE cyclooxygenase II; prostaglandins; obesity; metabolic syndrome; energy
   metabolism
ID ADIPOSE-TISSUE INFLAMMATION; CYCLOOXYGENASE-2 EXPRESSION; PROSTAGLANDIN
   E-2; NONALCOHOLIC STEATOHEPATITIS; ADIPOCYTE DIFFERENTIATION; OXIDATIVE
   STRESS; RECEPTOR; WHITE; CELECOXIB; LIVER
AB Obesity and insulin resistance are two major risk factors for the development of metabolic syndrome, type 2 diabetes and associated cardiovascular diseases (CVDs). Cyclooxygenase (COX), a rate-limiting enzyme responsible for the biosynthesis of prostaglandins (PGs), exists in two isoforms: COX-1, the constitutive form, and COX-2, mainly the inducible form. COX-2 is the key enzyme in eicosanoid metabolism that converts eicosanoids into a number of PGs, including PGD(2), PGE(2), PGF(2 alpha), and prostacyclin (PGI(2)), all of which exert diverse hormone-like effects via autocrine or paracrine mechanisms. The COX-2 gene and immunoreactive proteins have been documented to be highly expressed and elevated in adipose tissue (AT) under morbid obesity conditions. On the other hand, the environmental stress-induced expression and constitutive over-expression of COX-2 have been reported to play distinctive roles under different pathological and physiological conditions; i.e., over-expression of the COX-2 gene in white AT (WAT) has been shown to induce de novo brown AT (BAT) recruitment in WAT and then facilitate systemic energy expenditure to protect mice against high-fat diet-induced obesity. Hepatic COX-2 expression was found to protect against diet-induced steatosis, obesity, and insulin resistance. However, COX-2 activation in the epidydimal AT is strongly correlated with the development of AT inflammation, insulin resistance, and fatty liver in high-fat-diet-induced obese rats. This review will provide updated information regarding the role of COX-2-derived signals in the regulation of energy metabolism and the pathogenesis of obesity and MS.
C1 [Chan, Pei-Chi; Hsieh, Po-Shiuan] Natl Def Med Ctr, Inst Physiol, Taipei 114, Taiwan.
   [Liao, Min-Tser] Taoyuan Armed Forces Gen Hosp, Dept Pediat, Taoyuan 325, Taiwan.
   [Liao, Min-Tser] Triserv Gen Hosp, Dept Pediat, Taipei 114, Taiwan.
   [Hsieh, Po-Shiuan] Triserv Gen Hosp, Dept Med Res, Taipei 114, Taiwan.
C3 National Defense Medical Center; Tri-Service General Hospital;
   Tri-Service General Hospital
RP Hsieh, PS (corresponding author), Natl Def Med Ctr, Inst Physiol, Taipei 114, Taiwan.; Hsieh, PS (corresponding author), Triserv Gen Hosp, Dept Med Res, Taipei 114, Taiwan.
EM pshsieh@hotmail.com
RI Hsieh, Po-Shiuan/AAF-4173-2020
OI Hsieh, Po Shiuan/0000-0002-3402-9851
FU Taoyuan Armed Forces General Hospital [AFTYGH-10638]; Taipei, Taichung,
   Kaohsiung Veterans General Hospital, Tri-Service General Hospital,
   Academia Sinica Joint Research Program (VGH, TSGH, AS Joint Research
   Program) [VTA 105-T-4-1, VTA 106-T-7-1]
FX This study was supported by the Taoyuan Armed Forces General Hospital
   [grant number AFTYGH-10638] and the Taipei, Taichung, Kaohsiung Veterans
   General Hospital, Tri-Service General Hospital, Academia Sinica Joint
   Research Program (VGH, TSGH, AS Joint Research Program) [grant number
   VTA 105-T-4-1 and VTA 106-T-7-1].
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NR 53
TC 59
Z9 64
U1 0
U2 6
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD JUL 1
PY 2019
VL 20
IS 13
AR 3115
DI 10.3390/ijms20133115
PG 13
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA IL1EG
UT WOS:000477041100003
PM 31247902
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Sauvé, MF
   Feldman, F
   Koudoufio, M
   Ould-Chikh, NEH
   Ahmarani, L
   Sane, A
   N'Timbane, T
   El-Jalbout, R
   Patey, N
   Spahis, S
   Stintzi, A
   Delvin, E
   Levy, E
AF Sauve, Mathilde Foisy
   Feldman, Francis
   Koudoufio, Mireille
   Ould-Chikh, Nour-El-Houda
   Ahmarani, Lena
   Sane, Alain
   N'Timbane, Thierry
   El-Jalbout, Ramy
   Patey, Nathalie
   Spahis, Schohraya
   Stintzi, Alain
   Delvin, Edgard
   Levy, Emile
TI Glycomacropeptide for Management of Insulin Resistance and Liver
   Metabolic Perturbations
SO BIOMEDICINES
LA English
DT Article
DE milk peptide; nutraceutical; metabolic syndrome; metabolism; insulin
   signaling; inflammation; oxidative stress; mice; mitochondria
   dysfunction
ID HIGH-FAT DIET; CASEIN GLYCOMACROPEPTIDE; CARDIOVASCULAR-DISEASE; INDUCED
   OBESITY; GUT MICROBIOTA; MILK; MICE; PATHWAY; HEALTH; F-2-ISOPROSTANES
AB Background and Aims: The increasing prevalence and absence of effective global treatment for metabolic syndrome (MetS) are alarming given the potential progression to severe non-communicable disorders such as type 2 diabetes and nonalcoholic fatty liver disease. The purpose of this study was to investigate the regulatory role of glycomacropeptide (GMP), a powerful milk peptide, in insulin resistance and liver dysmetabolism, two central MetS conditions. Materials and Methods: C57BL/6 male mice were fed a chow (Ctrl), high-fat, high-sucrose (HFHS) diet or HFHS diet along with GMP (200 mg/kg/day) administered by gavage for 12 weeks. Results: GMP lowered plasma insulin levels (in response to oral glucose tolerance test) and HOMA-IR index, indicating a more elevated systemic insulin sensitivity. GMP was also able to decrease oxidative stress and inflammation in the circulation as reflected by the decline of malondialdehyde, F2 isoprostanes and lipopolysaccharide. In the liver, GMP raised the protein expression of the endogenous anti-oxidative enzyme GPx involving the NRF2 signaling pathway. Moreover, the administration of GMP reduced the gene expression of hepatic pro-inflammatory COX-2, TNF-alpha and IL-6 via inactivation of the TLR4/NF-kappa B signaling pathway. Finally, GMP improved hepatic insulin sensitization given the modulation of AKT, p38 MAPK and SAPK/JNK activities, thereby restoring liver homeostasis as revealed by enhanced fatty acid beta-oxidation, reduced lipogenesis and gluconeogenesis. Conclusions: Our study provides evidence that GMP represents a promising dietary nutraceutical in view of its beneficial regulation of systemic insulin resistance and hepatic insulin signaling pathway, likely via its powerful antioxidant and anti-inflammatory properties.
C1 [Sauve, Mathilde Foisy; Feldman, Francis; Koudoufio, Mireille; Ould-Chikh, Nour-El-Houda; Ahmarani, Lena; Sane, Alain; N'Timbane, Thierry; El-Jalbout, Ramy; Patey, Nathalie; Spahis, Schohraya; Delvin, Edgard; Levy, Emile] CHU Ste Justine, Res Ctr, Montreal, PQ H3T 1C5, Canada.
   [Sauve, Mathilde Foisy; Feldman, Francis; Koudoufio, Mireille; Ahmarani, Lena; Spahis, Schohraya; Levy, Emile] Univ Montreal, Dept Nutr, Montreal, PQ H3C 3J7, Canada.
   [El-Jalbout, Ramy] Univ Montreal, Dept Radiol, Montreal, PQ H3T 1C5, Canada.
   [Patey, Nathalie] Univ Montreal, Dept Pathol, Montreal, PQ H3T 1C5, Canada.
   [Stintzi, Alain] Univ Ottawa, Fac Med, Ottawa Inst Syst Biol, Dept Biochem Microbiol & Immunol, Ottawa, ON K1H 8M5, Canada.
   [Delvin, Edgard] Univ Montreal, Dept Biochem, Montreal, PQ H3T 1C5, Canada.
C3 Universite de Montreal; Universite de Montreal; Universite de Montreal;
   Universite de Montreal; University of Ottawa; Universite de Montreal
RP Levy, E (corresponding author), CHU Ste Justine, Res Ctr, Montreal, PQ H3T 1C5, Canada.; Levy, E (corresponding author), Univ Montreal, Dept Nutr, Montreal, PQ H3C 3J7, Canada.
EM mathilde.foisy.sauve@umontreal.ca; francis.feldman@umontreal.ca;
   mireille.koudoufio@umontreal.ca; nour-el-houda.ould-chikh@umontreal.ca;
   lena.ahmarani@gmail.com; sanealaintheo@gmail.com;
   mintyathierry@yahoo.ca; ramy.el-jalbout.med@ssss.gouv.qc.ca;
   natalie.patey.hsj@ssss.gouv.qc.ca; schohraya.spahis.hsj@ssss.gouv.qc.ca;
   astintzi@uottawa.ca; delvine@sympatico.ca;
   emile.levy.hsj@ssss.gouv.qc.ca
RI Jalbout, Ramy/AAT-6880-2020
OI Feldman, Francis/0000-0003-2758-9305; Spahis,
   Schohraya/0000-0003-4130-4994; Stintzi, Alain/0000-0003-3728-4038;
   Delvin, Edgard/0000-0002-3130-7748
FU Dairy Farmers of Canada; CHU Sainte-Justine Doctoral Scholarship; JA
   deSeve Research Chair in nutrition
FX This research was funded by research grants from the Dairy Farmers of
   Canada & the JA deSeve Research Chair in nutrition (E.L.) and CHU
   Sainte-Justine Doctoral Scholarship (M.F.S.).
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NR 60
TC 13
Z9 14
U1 1
U2 12
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2227-9059
J9 BIOMEDICINES
JI Biomedicines
PD SEP
PY 2021
VL 9
IS 9
AR 1140
DI 10.3390/biomedicines9091140
PG 15
WC Biochemistry & Molecular Biology; Medicine, Research & Experimental;
   Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Research & Experimental Medicine;
   Pharmacology & Pharmacy
GA UX0TB
UT WOS:000700560300001
PM 34572325
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Höhn, A
   König, J
   Jung, T
AF Hoehn, Annika
   Koenig, Jeannette
   Jung, Tobias
TI Metabolic Syndrome, Redox State, and the Proteasomal System
SO ANTIOXIDANTS & REDOX SIGNALING
LA English
DT Review
DE proteasome; metabolism; inflammation; redox; ROS; nutrition
ID OXIDATIVE-STRESS; OXIDIZED PROTEINS; 20S PROTEASOME; 26S PROTEASOME;
   INTRACELLULAR-DISTRIBUTION; ENDOTHELIAL DYSFUNCTION; DIABETIC
   CARDIOMYOPATHY; INFLAMMATORY RESPONSE; HT22 CELLS; ACTIVATION
AB Significance: Since the metabolic syndrome (MS) and pathologies associated with/resulting from metabolic dysregulations became a worldwide spreading and growing problem, the mechanisms mediating the according cellular changes got into a focus of interest. The ubiquitin-proteasomal system (UPS) is the main regulator of both the functional and dysfunctional protein pool of (not only) mammalian cells-thus, it is obvious that an impact on this system may also affect cellular functionality that directly depends on permanent regulation/adaption of the cell's proteostasis. However, the according research is still at the beginning.
   Recent Advances: It was also recently shown that maintaining a highly functional UPS positively correlates with increased health or even life span, thus modulation or restoration of UPS function may be an effective approach alleviating or even preventing MS detrimental consequences.
   Critical Issues: Even if many consequences of metabolic dysregulation such as a slight but chronic redox shift to a more oxidative state (i.e., a low-grade systemic inflammation that increases reactive oxygen species formation, lipid peroxidation, protein oxidation, formation of advanced glycation end products, glycosylation, S-glutathionylation, redox shifts, endoplasmic reticulumstress, unfolded protein response, expression of transcription factors, and release k of cytokines) are already known to affect the highly redox-regulated UPS, experimental data about UPS changes that are directly mediated by glucotoxic and/or lipotoxic stress are still rarely published.
   Future Directions: It may be taken into account that many MS-related pathologic changes result from UPS dysfunction or dysregulation. In this review, the main interface between MS effects and their impact on the UPS are highlighted since they may direct to new therapeutic approaches.
C1 [Hoehn, Annika; Koenig, Jeannette; Jung, Tobias] German Inst Human Nutr Potsdam Rehbruecke DIfE, Dept Mol Toxicol, Arthur Scheunert Allee 114-116, D-14558 Nuthetal, Germany.
   [Hoehn, Annika] German Ctr Diabet Res DZD, Neuherberg, Germany.
C3 Leibniz Association; Deutsches Institut fur Ernahrungsforschung
   Potsdam-Rehbrucke (DIfE); German Center for Diabetes Research (DZD)
RP Jung, T (corresponding author), German Inst Human Nutr Potsdam Rehbruecke DIfE, Dept Mol Toxicol, Arthur Scheunert Allee 114-116, D-14558 Nuthetal, Germany.
EM tobias.jung@dife.de
OI Hohn, Annika/0000-0003-1306-2668; Konig, Jeannette/0000-0003-3217-573X
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NR 78
TC 17
Z9 20
U1 0
U2 17
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1523-0864
EI 1557-7716
J9 ANTIOXID REDOX SIGN
JI Antioxid. Redox Signal.
PD DEC 1
PY 2016
VL 25
IS 16
BP 902
EP 917
DI 10.1089/ars.2016.6815
PG 16
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA EC6RA
UT WOS:000388262600004
PM 27412984
DA 2025-06-11
ER

PT J
AU Saruwatari, J
   Yasui-Furukori, N
   Kamihashi, Y
   Yoshimori, Y
   Oniki, K
   Tsuchimine, H
   Noai, M
   Sato, Y
   Nakagami, T
   Sugawara, N
   Saito, M
   Fujii, K
   Kajiwara, Y
   Mihara, H
   Ogata, Y
   Kaneko, S
   Nakagawa, K
AF Saruwatari, Junji
   Yasui-Furukori, Norio
   Kamihashi, Yoko
   Yoshimori, Yuki
   Oniki, Kentaro
   Tsuchimine, Hoko
   Noai, Madoka
   Sato, Yasushi
   Nakagami, Taku
   Sugawara, Norio
   Saito, Manabu
   Fujii, Kira
   Kajiwara, Yami
   Mihara, Huichi
   Ogata, Yasuhiro
   Kaneko, Sunao
   Nakagawa, Kazuko
TI Possible associations between antioxidant enzyme polymorphisms and
   metabolic abnormalities in patients with schizophrenia
SO NEUROPSYCHIATRIC DISEASE AND TREATMENT
LA English
DT Article
DE schizophrenia; metabolic syndrome; oxidative stress; glutathione
   S-transferase; superoxide dismutase 2; polymorphism
ID MANGANESE SUPEROXIDE-DISMUTASE; GLUTATHIONE S-TRANSFERASES; DRUG-NAIVE
   PATIENTS; INDUCED WEIGHT-GAIN; OXIDATIVE STRESS; CARDIOVASCULAR
   MORTALITY; GLUCOSE-TOLERANCE; DIABETES-MELLITUS; RISK-FACTORS; GENOTYPES
AB Background: This study investigated the possible association between common and potentially functional polymorphisms of antioxidant enzymes and metabolic abnormalities in patients with schizophrenia.
   Methods: The possible associations of the glutathione S-transferase (GST) M1 null and GSTT1 null genotypes, and the superoxide dismutase 2 (SOD2) Val16Ala polymorphism with the risks of being overweight and having metabolic syndrome were examined using a logistic regression analysis in 154 schizophrenic Japanese patients and 203 controls.
   Results: Among smokers with schizophrenia, the risks of being overweight and having decreased high-density lipoprotein cholesterol were significantly higher in those with the GSTM1 null genotype than in those with the present genotype (odds ratio 3.20 and 3.15, P= 0.03 and P= 0.04, respectively), while among nonsmokers with schizophrenia, the risk of an abnormal waist circumference was lower in those with the GSTM1 null genotype (odds ratio 0.34, P= 0.04). The risk of a decreased high-density lipoprotein cholesterol level was significantly higher in patients with the combined GSTM1 null and GSTT1 present genotypes than in those with the present genotypes of both genes (odds ratio 3.60, P, 0.01). The SOD2 Val16Ala polymorphism was not associated with risk of metabolic abnormalities in either group.
   Conclusion: The present study suggests that the GSTM1 null genotype, in combination with smoking status or GSTT1 genotype, might be associated with the metabolic abnormalities in patients with schizophrenia.
C1 [Saruwatari, Junji; Kamihashi, Yoko; Yoshimori, Yuki; Oniki, Kentaro; Noai, Madoka; Kajiwara, Yami; Nakagawa, Kazuko] Kumamoto Univ, Grad Sch Pharmaceut Sci, Div Pharmacol & Therapeut, Kumamoto 8620973, Japan.
   [Yasui-Furukori, Norio; Tsuchimine, Hoko; Sugawara, Norio; Saito, Manabu; Fujii, Kira; Kaneko, Sunao] Hirosaki Univ, Sch Med, Dept Neuropsychiat, Hirosaki, Aomori 036, Japan.
   [Sato, Yasushi] Hirosaki Aiseikai Hosp, Dept Psychiat, Hirosaki, Aomori, Japan.
   [Nakagami, Taku] Odate Municipal Gen Hosp, Dept Psychiat, Odate, Japan.
   [Mihara, Huichi] Mihara Life Care Clin, Kumamoto, Japan.
   [Ogata, Yasuhiro] Japanese Red Cross Kumamoto Hlth Care Ctr, Kumamoto, Japan.
   [Nakagawa, Kazuko] Kumamoto Univ, Ctr Clin Pharmaceut Sci, Kumamoto, Japan.
C3 Kumamoto University; Hirosaki University; Kumamoto University
RP Saruwatari, J (corresponding author), Kumamoto Univ, Grad Sch Pharmaceut Sci, Div Pharmacol & Therapeut, Chuo Ku, 5-1 Oe Honmachi, Kumamoto 8620973, Japan.
EM junsaru@gpo.kumamoto-u.ac.jp
RI Saruwatari, Junji/Q-7748-2019
FU Japan Research Foundation for Clinical Pharmacology; KAKENHI [23510348,
   24590652, 25860117]; Smoking Research Foundation; Grants-in-Aid for
   Scientific Research [25860117, 24590652, 23510348] Funding Source: KAKEN
FX The authors wish to thank all of the study participants. This work was
   supported by grants from the Japan Research Foundation for Clinical
   Pharmacology, the Research Group for Schizophrenia, and KAKENHI
   (23510348, 24590652, 25860117), and in part by a grant from the Smoking
   Research Foundation. The authors thank Yoshiyuki Tsuda and Motoki
   Imamura for their help with the DNA extraction and genotyping
   polymorphisms.
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NR 46
TC 14
Z9 15
U1 0
U2 8
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
EI 1178-2021
J9 NEUROPSYCH DIS TREAT
JI Neuropsychiatr. Dis. Treat.
PY 2013
VL 9
BP 1683
EP 1698
DI 10.2147/NDT.S52585
PG 16
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Psychiatry
GA 244JT
UT WOS:000326385000001
PM 24204153
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Huang, YX
   Zhao, LQ
   Yan, YX
   Chen, JY
   Liu, PF
   Xv, WC
   Qian, G
   Li, CJ
   Liang, SY
   Zou, HQ
   Li, YQ
AF Huang, Yuxiang
   Zhao, Liqin
   Yan, Yuxiang
   Chen, Jingyu
   Liu, Pengfei
   Xv, Weicheng
   Qian, Ge
   Li, Chijian
   Liang, Shiyi
   Zou, Hequn
   Li, Yongqiang
TI PBMCs to Stress-Associated miR-18a-5p and miR-22-3p Ratios as New
   Indicators of Metabolic Syndrome
SO BIOMED RESEARCH INTERNATIONAL
LA English
DT Article
ID TYPE-2 DIABETES-MELLITUS; BLOOD MONONUCLEAR-CELLS; POTENTIAL ROLE;
   EXPRESSION; BIOMARKERS; MICRORNAS; VULNERABILITY
AB Purpose. Metabolic syndrome (MetS) is associated with chronic stress. miR-18a-5p and miR-22-3p are two miRNAs which can target the glucocorticoid receptor. This study looked at the changes in metabolic parameters and the predictive value of the peripheral blood mononuclear cells (PBMCs) to stress-associated miRNA ratios as new indicators in subjects with and without MetS in southern China. Patients and Methods. There were 81 participants (39 with MetS and 42 without MetS) in this cross-sectional study. The potential miRNAs were filtrated in the GEO database. The expression of miR-18a-5p and miR-22-3p in PBMCs was evaluated by quantitative reverse transcription polymerase chain reaction (qRT-PCR). The risk of miRNA and PBMCs to stress-associated miRNA ratios contributing to the presence of MetS was estimated by univariate and multivariate logistic regression models. The area under the receiver operating characteristic curve (AUC) was used to evaluate diagnostic accuracy. Results. MetS was positively correlated with cortisol, IL-6, lymphocyte to miR-18a-5p ratio (LT18R), lymphocyte to miR-22-3p ratio (LT22R), monocyte to miR-18a-5p ratio (MT18R), monocyte to miR-22-3p ratio (MT22R), PBMCs to miR-18a-5p ratio (PT18R), and PBMCs to miR-22-3p ratio (PT22R) and negatively associated with the expression levels of miR-18a-5p and miR-22-3p (P<0.05). In addition, PT18R (odds ratio: 0.894; 95% CI: 0.823-0.966; P<0.001) and PT22R (odds ratio: 0.809; 95% CI: 0.717-0.900; P<0.001) were independent predictors of MetS, respectively. A receiver operating characteristic (ROC) curve analysis was performed to assess the value of the PT18R-PT22R (PMR) panel (odds ratio: 0.905; 95% CI: 0.838-0.971; P<0.001) for predicting MetS. The area under the curve yielded a cut-off value of 0.608, with sensitivity of 74.4% and specificity of 95.2% (P<0.001). Conclusion. In summary, miR-18a-5p and miR-22-3p in PBMCs may be important biomarkers of stress reaction and may play a role in vulnerability to MetS. Besides, the inflammatory cells to the two miRNA ratios demonstrated high accuracy in the diagnosis of MetS.
C1 [Huang, Yuxiang; Xv, Weicheng; Qian, Ge; Li, Chijian; Liang, Shiyi; Zou, Hequn; Li, Yongqiang] Southern Med Univ, Affiliated Hosp 3, Dept Nephrol, Inst Nephrol & Urol, Guangzhou, Peoples R China.
   [Zhao, Liqin] Southern Med Univ, Ctr Hlth Management, Affiliated Hosp 3, Guangzhou, Peoples R China.
   [Yan, Yuxiang] Capital Med Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing, Peoples R China.
   [Chen, Jingyu; Liu, Pengfei] Southern Med Univ, Affiliated Hosp 3, Dept Clin Lab, Guangzhou, Peoples R China.
C3 Southern Medical University - China; Southern Medical University -
   China; Capital Medical University; Southern Medical University - China
RP Li, YQ (corresponding author), Southern Med Univ, Affiliated Hosp 3, Dept Nephrol, Inst Nephrol & Urol, Guangzhou, Peoples R China.
EM 1255856885@qq.com; 940349991@qq.com; yanyxepi@ccmu.edu.cn;
   645411106@qq.com; 42219399@qq.com; drxwc@qq.com; 363316700@qq.com;
   1139583983@qq.com; l95s18y@163.com; hequnzou@hotmail.com;
   liyongqiang851@163.com
RI Zou, He/GXH-0280-2022; chen, jingyu/AAY-2275-2021
OI Huang, Yuxiang/0000-0003-1329-8814; Xu, Weicheng/0000-0003-1621-8787
FU Science and Technology Planning Project of Tianhe District, Guangzhou
   City [201704KW011]; Science and Technology Planning Project of Southern
   Medical University [CX2016N018]; Natural Science Foundation of Guangdong
   Province [2016A030313559]; South Wisdom Valley Innovative Research Team
   Program [CXTD-004,2014]; Science and Technology Program of Guangzhou
   [201604020015]
FX This work was supported by the Science and Technology Planning Project
   of Tianhe District, Guangzhou City (No. 201704KW011), the Science and
   Technology Planning Project of Southern Medical University (No.
   CX2016N018), the Natural Science Foundation of Guangdong Province (No.
   2016A030313559), the South Wisdom Valley Innovative Research Team
   Program (No. CXTD-004,2014), and the Science and Technology Program of
   Guangzhou (No. 201604020015).
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NR 23
TC 11
Z9 11
U1 0
U2 4
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2314-6133
EI 2314-6141
J9 BIOMED RES INT
JI Biomed Res. Int.
PD APR 24
PY 2020
VL 2020
AR 8159342
DI 10.1155/2020/8159342
PG 10
WC Biotechnology & Applied Microbiology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Research & Experimental Medicine
GA LM5LP
UT WOS:000532290300003
PM 32382575
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Gorur, GD
   Ciftci, EA
   Kozdag, G
   Isgoren, S
   Oc, MA
   Haksal, C
   Gur, M
   Demir, H
AF Gorur, Gozde Daglioz
   Ciftci, Esra Alkan
   Kozdag, Guliz
   Isgoren, Serkan
   Oc, Murat Alper
   Haksal, Cagla
   Gur, Muammer
   Demir, Hakan
TI Reduced heart rate response to dipyridamole in patients undergoing
   myocardial perfusion SPECT
SO ANNALS OF NUCLEAR MEDICINE
LA English
DT Article
DE Myocardial perfusion scintigraphy; Dipyridamole; Heart rate
ID CORONARY-ARTERY-DISEASE; LEFT-VENTRICULAR DYSFUNCTION; AUTONOMIC
   NEUROPATHY; VASODILATOR STRESS; HEMODYNAMIC-RESPONSES; CARDIOVASCULAR
   RISK; METABOLIC SYNDROME; DIABETIC-PATIENTS; RENAL-FAILURE; ADENOSINE
AB A mild decrease in blood pressure and increase in heart rate (HR) are considered normal hemodynamic responses to dipyridamole. In this study, we tried to investigate HR response to dipyridamole and its predictors in patients undergoing gated myocardial perfusion single photon emission computed tomography (SPECT).
   201 consecutive patients undergoing dipyridamole stress Tc99m-MIBI or Tl-201 gated myocardial perfusion SPECT were prospectively enrolled. Dipyridamole was infused over 4 min and radiopharmaceutical was injected 3 min after the end of infusion. A reduced heart rate response to dipyridamole considered if the HR ratio (peak HR/rest HR) was 1.20 or less. Stress (sLVEF), rest (rLVEF) left ventricular ejection fractions, stress and rest motion (SMS, RMS) and thickening scores (STS, RTS) were derived automatically by QGS. Summed stress score (SSS), summed rest score (SRS), and summed difference score (SDS) for myocardial perfusion were calculated. Patients were grouped according to HR response and groups were compared. A logistic regression analysis was used to determine independent predictors of reduced HR response.
   Reduced HR response was found in 78 % of patients. Patients with abnormal HR response were more frequently had a history of diabetes mellitus, chronic renal failure, and had lower high-density lipoprotein (HDL) levels. Peak HR, SSS, SRS, sLVEF and rLVEF were lower; rest HR, RTS, and the number of patients with a parts per thousand currency sign45 % sLVEF and rLVEF were higher in reduced HR response group (all p < 0.05). There was no difference between groups by means of gender, rest and peak systolic or diastolic tension, SDS, SMS, STS, RMS, history of hypertension, peripheral arterial disease, metabolic syndrome, coronary interventions, digoxin, calcium channel blocker or beta blocker usage. Multivariable logistic regression analysis demonstrated that the independent predictors of reduced HR response were HDL, rest HR and SSS. When HDL was removed from the model, chronic renal failure also emerged as an independent predictor.
   Reduced HR response to dipyridamole is associated with ventricular dysfunction, cardiac autonomic neuropathy. Low HDL levels also seem to be related with reduced HR response.
C1 [Gorur, Gozde Daglioz; Ciftci, Esra Alkan; Isgoren, Serkan; Oc, Murat Alper; Haksal, Cagla; Gur, Muammer; Demir, Hakan] Kocaeli Univ, Sch Med, Dept Nucl Med, TR-41380 Umuttepe, Kocaeli, Turkey.
   [Kozdag, Guliz] Kocaeli Univ, Sch Med, Dept Cardiol, TR-41380 Umuttepe, Kocaeli, Turkey.
C3 Kocaeli University; Kocaeli University
RP Gorur, GD (corresponding author), Kocaeli Univ, Sch Med, Dept Nucl Med, TR-41380 Umuttepe, Kocaeli, Turkey.
EM gozdedaglioz@yahoo.com
RI isgoren, Serkan/A-5733-2018
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NR 27
TC 6
Z9 6
U1 0
U2 11
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0914-7187
J9 ANN NUCL MED
JI Ann. Nucl. Med.
PD OCT
PY 2012
VL 26
IS 8
BP 609
EP 615
DI 10.1007/s12149-012-0618-z
PG 7
WC Radiology, Nuclear Medicine & Medical Imaging
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Radiology, Nuclear Medicine & Medical Imaging
GA 024CJ
UT WOS:000310085000001
PM 22714113
DA 2025-06-11
ER

PT J
AU Gholamil, M
   Rezvanfar, MR
   Delavar, M
   Abdollahl, M
   Khosrowbeygi, A
AF Gholamil, Mahsa
   Rezvanfar, Mohammad Reza
   Delavar, Mostafa
   Abdollahl, Mandi
   Khosrowbeygi, Ali
TI Effects of Coenzyme Q10 Supplementation on Serum Values of
   Gamma-glutamyl transferase, Pseudocholinesterase, Bilirubin, Ferritin,
   and High-Sensitivity C-Reactive Protein in Women with Type 2 Diabetes
SO EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
LA English
DT Article
DE type 2 diabetes; coenzyme Q(10); butyrylcholinesterase; gamma-glutamyl
   transferase; ferritin
ID GLYCEMIC CONTROL; DOUBLE-BLIND; INSULIN SENSITIVITY; METABOLIC SYNDROME;
   OXIDATIVE STRESS; ALPHA-TOCOPHEROL; LIVER-ENZYMES;
   BUTYRYLCHOLINESTERASE; MELLITUS; ARTERY
AB Background Type 2 diabetes mellitus (T2DM) is a disease associated with increased oxidative stress which results from mitochondrial dysfunction. Coenzyme Q(10) (CoQ(10)) is an essential antioxidant for energy production in mitochondria. The purpose of this randomized double-blind clinical trial study was to evaluate the effects of CoQ(10) supplementation on serum values of gamma-glutamyl transferase (GGT), pseudocholinesterase (PchE), bilirubin, ferritin, and high-sensitivity c-reactive protein (hs-CRP) and metabolic syndrome biomarkers in women with T2DM.
   Material & Methods Eighty women with T2DM enrolled in this study. Thirty six of them were randomized in the drug group (receiving 100 mg/day of CoQ(10)) and 44 women were randomized in placebo group. Intervention was continued for 12 weeks. In both groups 35 subjects finished the study and were included in the analysis. Serum levels of the variables were measured before and after supplementation.
   Results Serum values of FBS (P = 0.039), HOMA-IR (P = 0.01), ferritin (P < 0.001), total cholesterol (TC) (P = 0.006), LDL-C (P = 0.007) decreased and HDL-C (P = 0.02) increased significantly in the drug group after intervention. Serum levels of triglyceride (P = 0.09) decreased marginally in CoQ(10) group.
   Conclusions The results of the current study had shown that after supplementation with 100 mg/day of CoQ(10) for 12 weeks, serum values of FBS, HOMA-IR, TC, LDL-C and ferritin were decreased and values of HDL-C were increased in women with T2DM.
C1 [Gholamil, Mahsa] Arak Univ Med Sci, Student Res Comm, Arak, Iran.
   [Rezvanfar, Mohammad Reza] Arak Univ Med Sci, Sch Med, Dept Internal Med, Arak, Iran.
   [Delavar, Mostafa] Arak Univ Med Sci, Sch Med, Dept Pharmacol, Arak, Iran.
   [Abdollahl, Mandi] Arak Univ Med Sci, Araks Med Sci Univ, Control Lab Food & Beverage Decorat Hygien Prod, Arak, Iran.
   [Khosrowbeygi, Ali] Arak Univ Med Sci, Sch Med, Dept Biochem & Genet, Arak, Iran.
RP Khosrowbeygi, A (corresponding author), Arak Univ Med Sci, Sch Med, Dept Biochem & Genet, Arak, Iran.
EM khosrowbeygi@yahoo.com
FU Research Council of Arak University of Medical Sciences [2413]
FX The authors gratefully acknowledge the Research Council of Arak
   University of Medical Sciences for their financial support (Grant
   Number: 2413). This work was performed in partial fulfillment of the
   requirements for the M.Sc. degree of Mahsa Gholami, in the School of
   Medicine, Arak University of Medical Sciences, Arak, Iran. The authors
   would like to thank Ms. Fateme Rafiei for her assistance in statistical
   analysis. We also should appreciate all patients for their patience and
   time.
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NR 57
TC 18
Z9 19
U1 0
U2 4
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0947-7349
EI 1439-3646
J9 EXP CLIN ENDOCR DIAB
JI Exp. Clin. Endocrinol. Diabet.
PD MAY
PY 2019
VL 127
IS 5
BP 311
EP 319
DI 10.1055/s-0043-124183
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA HX1CV
UT WOS:000467127900007
PM 29365333
DA 2025-06-11
ER

PT J
AU Alam, MA
   Kauter, K
   Withers, K
   Sernia, C
   Brown, L
AF Alam, Md. Ashraful
   Kauter, Kathleen
   Withers, Kerry
   Sernia, Conrad
   Brown, Lindsay
TI Chronic L-arginine treatment improves metabolic, cardiovascular and
   liver complications in diet-induced obesity in rats
SO FOOD & FUNCTION
LA English
DT Article
ID NONALCOHOLIC FATTY LIVER; HEPATIC INSULIN-RESISTANCE; NITRIC-OXIDE
   PATHWAY; HIGH-CARBOHYDRATE; ATTENUATION; MECHANISMS; PROTECTION;
   NUTRITION; MUSCLE; MODEL
AB L-Arginine is an important dietary amino acid in both health and disease, especially of the cardiovascular system. This study has determined whether dietary supplementation with L-arginine attenuates cardiovascular, metabolic, pancreatic and liver changes in a rat model of the human metabolic syndrome. Male Wistar rats (8-9 weeks old) were divided into four groups. Two groups of rats were fed a corn starch-rich diet (C) whereas the other two groups were given a high carbohydrate, high fat diet (H) with 25% fructose in the drinking water, for 16 weeks. One group fed each diet was supplemented with 5% L-arginine in the food for the final 8 weeks of this protocol. The corn starch diet (C) contained similar to 68% carbohydrates mainly as polysaccharides, while the high-carbohydrate, high-fat diet contained similar to 68% carbohydrates mainly as fructose and sucrose together with 24% fat mainly as saturated and monounsaturated fats from beef tallow. The high-carbohydrate, high-fat diet-fed rats showed the symptoms of metabolic syndrome including obesity and hypertension with heart and liver damage. Supplementation with L-arginine attenuated impairment in left ventricular and liver structure and function, glucose tolerance, and decreased blood pressure, abdominal fat pads, inflammatory cell infiltration, pancreatic cell hypertrophy and oxidative stress. This study indicates that oral supplementation with L-arginine attenuated or normalised obesity-related changes in the heart, liver and pancreas by reducing inflammation and oxidative stress associated with high carbohydrate, high fat feeding in rats.
C1 [Alam, Md. Ashraful; Sernia, Conrad] Univ Queensland, Sch Biomed Sci, Brisbane, Qld 4072, Australia.
   [Kauter, Kathleen; Withers, Kerry; Brown, Lindsay] Univ So Queensland, Dept Biol & Phys Sci, Toowoomba, Qld 4350, Australia.
C3 University of Queensland; University of Southern Queensland
RP Alam, MA (corresponding author), Univ Queensland, Sch Biomed Sci, Brisbane, Qld 4072, Australia.
EM Lindsay.Brown@usq.edu.au
RI Alam, Ashraful/G-1964-2014
OI Alam, Md Ashraful/0000-0001-7596-5868; Kauter, Kate/0000-0003-2470-9172
FU Merit Development Scholarship from the Islamic Development Bank, Jeddah,
   Saudi Arabia; UQIRTA from The University of Queensland
FX MAA was supported by a Merit Development Scholarship from the Islamic
   Development Bank, Jeddah, Saudi Arabia and UQIRTA from The University of
   Queensland. We thank Mr Brian Bynon, School of Veterinary Science, and
   Mr Paul Addison, School of Biomedical Sciences, both at The University
   of Queensland, for their help with plasma biochemical analyses and
   histology, respectively. We also thank Mr Jason Brightwell, The Prince
   Charles Hospital, Brisbane, for his assistance with echocardiography.
   All the authors have nothing to disclose.
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NR 49
TC 36
Z9 37
U1 2
U2 23
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PD JAN
PY 2013
VL 4
IS 1
BP 83
EP 91
DI 10.1039/c2fo30096f
PG 9
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA 057EC
UT WOS:000312544200008
PM 23010865
DA 2025-06-11
ER

PT J
AU Gattere, G
   Stojanovic-Pérez, A
   Monseny, R
   Martorell, L
   Ortega, L
   Montalvo, I
   Solé, M
   Algora, MJ
   Cabezas, A
   Reynolds, RM
   Vilella, E
   Labad, J
AF Gattere, Giulia
   Stojanovic-Perez, Alexander
   Monseny, Rosa
   Martorell, Lourdes
   Ortega, Laura
   Montalvo, Itziar
   Sole, Montse
   Jose Algora, Maria
   Cabezas, Angel
   Reynolds, Rebecca M.
   Vilella, Elisabet
   Labad, Javier
TI Gene-environment interaction between the brain-derived neurotrophic
   factor Val66Met polymorphism, psychosocial stress and dietary intake in
   early psychosis
SO EARLY INTERVENTION IN PSYCHIATRY
LA English
DT Article
DE BDNF Val66Met; brain-derived neurotrophic factor; diet; early psychosis;
   stress
ID PITUITARY-ADRENAL AXIS; FOOD-INTAKE REGULATION; METABOLIC SYNDROME; LIFE
   EVENTS; FACTOR BDNF; SCHIZOPHRENIA; OBESITY; QUESTIONNAIRE; INDIVIDUALS;
   CORTISOL
AB AimThe brain-derived neurotrophic factor (BDNF) is a major participant in the regulation of food intake and may play a role in the regulation of the stress response. We aimed to investigate whether there is a gene-environment interaction in the relationship between stress and BDNF Val66Met polymorphism in relation to dietary patterns in a sample of subjects with early psychosis.
   MethodsWe studied 124 early psychotic disorder (PD) patients, 36 At-Risk Mental States (ARMS) and 62 healthy subjects (HS). Dietary patterns were examined by a dietician. Physical activity, life stress and perceived stress were assessed by validated questionnaires. BDNF Val66Met polymorphism (rs6265) was genotyped. A gene-environment interaction was tested with multiple linear regression analysis while adjusting for covariates.
   ResultsPerceived stress was not associated with calorie intake in HS. In ARMS subjects, Met-carriers who presented low-perceived stress were associated with increased caloric intake. Conversely, those who presented high-perceived stress were associated with reduced caloric intake. In PD, perceived stress was neither associated with increased calorie intake without an effect by BDNF genotype nor a gene-environment interaction. Perceived stress was associated with food craving in PD patients, independent of genotype, and in ARMS or HS who were Val homozygous.
   ConclusionsThis study suggests that the common Val66Met polymorphism of the BDNF gene may modulate the relationship between life stress and calorie intake in subjects at risk for psychosis.
C1 [Gattere, Giulia; Stojanovic-Perez, Alexander; Monseny, Rosa; Martorell, Lourdes; Ortega, Laura; Sole, Montse; Jose Algora, Maria; Cabezas, Angel; Vilella, Elisabet] Univ Rovira & Virgili, Hosp Univ Inst Pere Mata, Early Intervent Serv & Res Dept, IISPV,CIBERSAM, Reus, Spain.
   [Montalvo, Itziar; Labad, Javier] Corp Sanitaria Univ Parc Tauli, UAB, Dept Psychiat, I3PT,CIBERSAM, Sabadell, Spain.
   [Reynolds, Rebecca M.] Univ Edinburgh, Queens Med Res Inst, Univ BHF Ctr Cardiovasc Sci, Endocrinol Unit, Edinburgh, Midlothian, Scotland.
C3 CIBER - Centro de Investigacion Biomedica en Red; CIBERSAM; Universitat
   Rovira i Virgili; Institut d'Investigacio Sanitaria Pere Virgili
   (IISPV); Autonomous University of Barcelona; Parc Tauli Hospital
   Universitari; CIBER - Centro de Investigacion Biomedica en Red;
   CIBERSAM; University of Edinburgh
RP Labad, J (corresponding author), Corp Sanitaria Univ Parc Tauli, Dept Psychiat, C Parc Tauli 1, Sabadell 08208, Spain.
EM jlabad@tauli.cat
RI Reynolds, Rebecca/C-3044-2008; Labad, Javier/AAF-6632-2020; Vilella,
   Elisabet/HII-9781-2022; Ortega, Laura/M-7042-2019
OI Martorell, Lourdes/0000-0003-4999-2197; Cabezas Serisa,
   Angel/0000-0001-8114-0264; Montalvo, Itziar/0000-0002-7320-5109; Sole,
   Montse/0000-0001-8871-2720; Ortega, Laura/0000-0003-2476-7700; Labad,
   Javier/0000-0003-2214-1886
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NR 38
TC 11
Z9 11
U1 0
U2 12
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1751-7885
EI 1751-7893
J9 EARLY INTERV PSYCHIA
JI Early Interv. Psychiatry
PD OCT
PY 2018
VL 12
IS 5
BP 811
EP 820
DI 10.1111/eip.12371
PG 10
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA GU3LX
UT WOS:000445180900006
PM 27629407
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Sawai, A
   Endo, M
   Suzuki, Y
   Watanabe, K
   Sawai, S
   Yamasue, K
   Bannai, Y
   Takeda, Y
   Fujikawa, T
   Ohno, M
   Fujii, H
   Tochikubo, O
AF Sawai, Asuka
   Endo, Mayu
   Suzuki, Yuho
   Watanabe, Kaito
   Sawai, Shinya
   Yamasue, Kotaro
   Bannai, Yuichi
   Takeda, Yuichi
   Fujikawa, Tetsuya
   Ohno, Masato
   Fujii, Hitoshi
   Tochikubo, Osamu
TI Relationship between the evaluation of lifestyle factors of elderly
   people as measured by the Health Wrist Watch and the health index
SO GAZZETTA MEDICA ITALIANA ARCHIVIO PER LE SCIENZE MEDICHE
LA English
DT Article
DE Stress; psychological; Exercise; Aged; Sleep; Life style; Health status
   indicators
ID LEPTIN LEVELS; GHRELIN
AB BACKGROUND: The Health Wrist Watch (HW; Seiko Epson Co., Ltd., Suwa, Japan) was developed to monitor and evaluate lifestyles as measured by heart rate (HR) variability, acceleration, and calculation of energy expenditure (EE). In this study, we verified the accuracy of the HW by comparing EE in 30 elderly people obtained from the HWwith that from a precise metabolizer (VO 2000 (R); Medical Graphics, Milan, Italy). Furthermore, the relationship in 33 elderly people between the risk of metabolic syndrome, results determined by a medical examination, and the lifestyle index measured by the HW were compared.
   METHODS: To investigate validity, controlled rest, mental arithmetic, and walking were measured with the HW and VO2000 in elderly men. In the application study, activity times (sleep, mental activity, mental stress, physical activity, exercise) and EE were measured with the HW. The HW data were compared with medical examination results regarding the risk of lifestyle-related disease.
   RESULTS: EE measured by the HW correlated significantly with VO2000 measurements for mental and physical activity performed high significant (r=0.89, P<0.01). Deep sleep time as measured by the HW correlated significantly (P<0.05) with body weight (r=-0.44), BMI (-0.41), abdominal circumference (-0.49), T-cho (-0.37), LDL-cho (-0.40), and lower limb muscle strength (0.42). Physical activity times correlated significantly with brachial-ankle pulse wave velocity (-0.51) (P<0.05).
   CONCLUSIONS: The HW could easily evaluate EE during mental and physical activity in elderly men. Physical activity times, EE, and sleep times as measured by the HW correlated significantly with the risk of metabolic syndrome and nursing care factors.
C1 [Sawai, Asuka] Kanagawa Inst Technol, Grad Sch Engn, Atsugi, Kanagawa, Japan.
   [Sawai, Asuka; Endo, Mayu; Suzuki, Yuho; Watanabe, Kaito] Kanagawa Inst Technol, Dept Nutr & Life Sci, Shimo Ogino 1030, Atsugi, Kanagawa 2430292, Japan.
   [Sawai, Shinya] Natl Def Acad, Dept Math & Phys, Yokosuka, Kanagawa, Japan.
   [Yamasue, Kotaro; Tochikubo, Osamu] Yokohama City Univ, Grad Sch Med, Yokohama, Kanagawa, Japan.
   [Bannai, Yuichi] Kanagawa Inst Technol, Dept Informat Media, Atsugi, Kanagawa, Japan.
   [Takeda, Yuichi] Kanagawa Inst Technol, Ctr Basic Educ & Integrated Learning, Atsugi, Kanagawa, Japan.
   [Fujikawa, Tetsuya] Yokohama Natl Univ, Ctr Hlth Serv Sci, Yokohama, Kanagawa, Japan.
   [Ohno, Masato] Yonago Coll, Natl Inst Technol, Yonago, Tottori, Japan.
   [Fujii, Hitoshi] Mejiro Univ, Dept Nursing, Saitama, Japan.
C3 Kanagawa Institute Technology; Kanagawa Institute Technology; National
   Defense Academy - Japan; Yokohama City University; Kanagawa Institute
   Technology; Kanagawa Institute Technology; Yokohama National University
RP Sawai, A (corresponding author), Kanagawa Inst Technol, Dept Nutr & Life Sci, Shimo Ogino 1030, Atsugi, Kanagawa 2430292, Japan.
EM asawai@bio.kanagawa-it.ac.jp
RI Fujikawa, Tetsuya/N-6520-2014
FU JSPS KAKENHI [15K00853]; Grants-in-Aid for Scientific Research
   [15K00853] Funding Source: KAKEN
FX This work was funded by JSPS KAKENHI Grant Number 15K00853. The authors
   declare no conflicts of interest.
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NR 29
TC 0
Z9 0
U1 0
U2 1
PU EDIZIONI MINERVA MEDICA
PI TURIN
PA CORSO BRAMANTE 83-85 INT JOURNALS DEPT., 10126 TURIN, ITALY
SN 0393-3660
EI 1827-1812
J9 GAZZ MED ITAL ARCH S
JI Gazz. Med. Ital. Arch. Sci. Med.
PD DEC
PY 2021
VL 180
IS 12
BP 785
EP 795
DI 10.23736/S0393-3660.19.04246-3
PG 11
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA ZM3DJ
UT WOS:000764242000003
DA 2025-06-11
ER

PT J
AU Sid, V
   Wu, N
   Sarna, LK
   Siow, YL
   House, JD
   Karmin, O
AF Sid, Victoria
   Wu, Nan
   Sarna, Lindsei K.
   Siow, Yaw L.
   House, James D.
   Karmin, O.
TI Folic acid supplementation during high-fat diet feeding restores AMPK
   activation via an AMP-LKB1-dependent mechanism
SO AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE
   PHYSIOLOGY
LA English
DT Article
DE AMP-activated protein kinase; liver kinase B1; AMP; nonalcoholic fatty
   liver disease; folic acid
ID HMG-COA REDUCTASE; PROTEIN-KINASE; LIVER-DISEASE; INTESTINAL-ABSORPTION;
   CHOLESTEROL-SYNTHESIS; METABOLIC SYNDROME; ENERGY-METABOLISM; FOLATE;
   LKB1; METFORMIN
AB AMPK is an endogenous energy sensor that regulates lipid and carbohydrate metabolism. Nonalcoholic fatty liver disease (NAFLD) is regarded as a hepatic manifestation of metabolic syndrome with impaired lipid and glucose metabolism and increased oxidative stress. Our recent study showed that folic acid supplementation attenuated hepatic oxidative stress and lipid accumulation in high-fat diet-fed mice. The aim of the present study was to investigate the effect of folic acid on hepatic AMPK during high-fat diet feeding and the mechanisms involved. Male C57BL/6J mice were fed a control diet (10% kcal fat), a high-fat diet (60% kcal fat), or a high-fat diet supplemented with folic acid (26 mg/kg diet) for 5 wk. Mice fed a high-fat diet exhibited hyperglycemia, hepatic cholesterol accumulation, and reduced hepatic AMPK phosphorylation. Folic acid supplementation restored AMPK phosphorylation (activation) and reduced blood glucose and hepatic cholesterol levels. Activation of AMPK by folic acid was mediated through an elevation of its allosteric activator AMP and activation of its upstream kinase, namely, liver kinase B1 (LKB1) in the liver. Consistent with in vivo findings, 5-methyltetrahydrofolate (bioactive form of folate) restored phosphorylation (activation) of both AMPK and LKB1 in palmitic acid-treated HepG2 cells. Activation of AMPK by folic acid might be responsible for AMPK-dependent phosphorylation of HMG-CoA reductase, leading to reduced hepatic cholesterol synthesis during high-fat diet feeding. These results suggest that folic acid supplementation may improve cholesterol and glucose metabolism by restoration of AMPK activation in the liver.
C1 [Sid, Victoria; Wu, Nan; Sarna, Lindsei K.; Siow, Yaw L.; Karmin, O.] St Boniface Hosp Res Ctr, Winnipeg, MB R2H 2A6, Canada.
   [Sid, Victoria; Wu, Nan; Siow, Yaw L.; Karmin, O.] Dept Physiol & Pathophysiol, Winnipeg, MB, Canada.
   [Sarna, Lindsei K.; House, James D.; Karmin, O.] Univ Manitoba, Dept Anim Sci, Winnipeg, MB R3T 2N2, Canada.
   [Siow, Yaw L.] Agr & Agri Food Canada, Winnipeg, MB, Canada.
   [House, James D.] Univ Manitoba, Dept Human Nutr Sci, Winnipeg, MB, Canada.
C3 University of Manitoba; Children's Hospital Research Institute of
   Manitoba; Saint Boniface Hospital; University of Manitoba; Agriculture &
   Agri Food Canada; University of Manitoba
RP Karmin, O (corresponding author), St Boniface Hosp Res Ctr, CCARM, Lab Integrat Biol, 351 Tache Ave, Winnipeg, MB R2H 2A6, Canada.
EM karmino@sbrc.ca
RI House, James/AAF-9299-2019; Siow, Yaw/AGE-1903-2022; House,
   James/I-7319-2013
OI House, James/0000-0003-1389-5491; Siow, Yaw/0000-0001-6623-2881; O,
   Karmin/0000-0002-2163-9458
FU Natural Sciences and Engineering Research Council of Canada; St.
   Boniface Hospital Research Centre
FX This study was supported, in part, by grants from the Natural Sciences
   and Engineering Research Council of Canada and St. Boniface Hospital
   Research Centre.
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NR 67
TC 40
Z9 43
U1 2
U2 27
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0363-6119
EI 1522-1490
J9 AM J PHYSIOL-REG I
JI Am. J. Physiol.-Regul. Integr. Comp. Physiol.
PD NOV 15
PY 2015
VL 309
IS 10
BP R1215
EP R1225
DI 10.1152/ajpregu.00260.2015
PG 11
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA CX7JT
UT WOS:000365878700003
PM 26400185
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Bakkar, NMZ
   Dwaib, HS
   Fares, S
   Eid, AH
   Al-Dhaheri, Y
   El-Yazbi, AF
AF Bakkar, Nour-Mounira Z.
   Dwaib, Haneen S.
   Fares, Souha
   Eid, Ali H.
   Al-Dhaheri, Yusra
   El-Yazbi, Ahmed F.
TI Cardiac Autonomic Neuropathy: A Progressive Consequence of Chronic
   Low-Grade Inflammation in Type 2 Diabetes and Related Metabolic
   Disorders
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE cardiac autonomic neuropathy; inflammation; reactive oxygen species;
   type 2 diabetes
ID SYMPATHETIC-NERVOUS-SYSTEM; RENIN-ANGIOTENSIN SYSTEM; C-REACTIVE
   PROTEIN; ADIPOSE-TISSUE; BAROREFLEX SENSITIVITY; INSULIN-RESISTANCE; GUT
   MICROBIOTA; OXIDATIVE STRESS; CHRONIC COMPLICATIONS; NORMOTENSIVE
   PATIENTS
AB Cardiac autonomic neuropathy (CAN) is one of the earliest complications of type 2 diabetes (T2D), presenting a silent cause of cardiovascular morbidity and mortality. Recent research relates the pathogenesis of cardiovascular disease in T2D to an ensuing chronic, low-grade proinflammatory and pro-oxidative environment, being the hallmark of the metabolic syndrome. Metabolic inflammation emerges as adipose tissue inflammatory changes extending systemically, on the advent of hyperglycemia, to reach central regions of the brain. In light of changes in glucose and insulin homeostasis, dysbiosis or alteration of the gut microbiome (GM) emerges, further contributing to inflammatory processes through increased gut and blood-brain barrier permeability. Interestingly, studies reveal that the determinants of oxidative stress and inflammation progression exist at the crossroad of CAN manifestations, dictating their evolution along the natural course of T2D development. Indeed, sympathetic and parasympathetic deterioration was shown to correlate with markers of adipose, vascular, and systemic inflammation. Additionally, evidence points out that dysbiosis could promote a sympatho-excitatory state through differentially affecting the secretion of hormones and neuromodulators, such as norepinephrine, serotonin, and gamma-aminobutyric acid, and acting along the renin-angiotensin-aldosterone axis. Emerging neuronal inflammation and concomitant autophagic defects in brainstem nuclei were described as possible underlying mechanisms of CAN in experimental models of metabolic syndrome and T2D. Drugs with anti-inflammatory characteristics provide potential avenues for targeting pathways involved in CAN initiation and progression. The aim of this review is to delineate the etiology of CAN in the context of a metabolic disorder characterized by elevated oxidative and inflammatory load.
C1 [Bakkar, Nour-Mounira Z.; Dwaib, Haneen S.; Eid, Ali H.; El-Yazbi, Ahmed F.] Amer Univ Beirut, Fac Med, Dept Pharmacol & Toxicol, Riad El Solh 1107 2020, Beirut 110236, Lebanon.
   [Fares, Souha] Amer Univ Beirut, Rafic Hariri Sch Nursing, Riad El Solh 1107 2020, Beirut 110236, Lebanon.
   [Eid, Ali H.] Qatar Univ, Coll Med, Dept Basic Med Sci, QU Hlth, Doha 2713, Qatar.
   [Eid, Ali H.] Qatar Univ, Biomed & Pharmaceut Res Unit, QU Hlth, Doha 2713, Qatar.
   [Al-Dhaheri, Yusra] United Arab Emirates Univ, Coll Sci, Dept Biol, Al Ain 15551, U Arab Emirates.
   [El-Yazbi, Ahmed F.] Alexandria Univ, Fac Pharm, Dept Pharmacol & Toxicol, Alexandria 21521, Egypt.
C3 American University of Beirut; American University of Beirut; Qatar
   University; Qatar University; United Arab Emirates University; Egyptian
   Knowledge Bank (EKB); Alexandria University
RP El-Yazbi, AF (corresponding author), Amer Univ Beirut, Fac Med, Dept Pharmacol & Toxicol, Riad El Solh 1107 2020, Beirut 110236, Lebanon.; Al-Dhaheri, Y (corresponding author), United Arab Emirates Univ, Coll Sci, Dept Biol, Al Ain 15551, U Arab Emirates.; El-Yazbi, AF (corresponding author), Alexandria Univ, Fac Pharm, Dept Pharmacol & Toxicol, Alexandria 21521, Egypt.
EM nb87@aub.edu.lb; hsd12@mail.aub.edu; sf31@aub.edu.lb; ae81@aub.edu.lb;
   yusra.aldhaheri@uaeu.ac.ae; ae88@aub.edu.lb
RI El-Yazbi, Ahmed/AAT-6837-2021; Bakkar, Nour/MGA-8112-2025; Fares,
   Silvano/H-4322-2011; Eid, Ali/ABD-6291-2021
OI Eid, Ali/0000-0003-3004-5675; El-Yazbi, Ahmed/0000-0003-3432-3038;
   Bakkar, Nour-Mounira/0000-0002-6403-9348; Dwaib,
   Haneen/0000-0002-2514-2617
FU Faculty of Medicine at the American University of Beirut, Medical
   Practice Plan [320148]; UAEU Program for Advanced Research [31S398-UPAR]
FX This work was funded by the Faculty of Medicine at the American
   University of Beirut, Medical Practice Plan, grant #320148 to A.F.E. and
   UAEU Program for Advanced Research, grant number 31S398-UPAR to Y.A.-D.
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NR 136
TC 31
Z9 33
U1 0
U2 6
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD DEC
PY 2020
VL 21
IS 23
AR 9005
DI 10.3390/ijms21239005
PG 20
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA PD2JY
UT WOS:000597518900001
PM 33260799
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Tousian, H
   Razavi, BM
   Hosseinzadeh, H
AF Tousian, Hourieh
   Razavi, Bibi Marian
   Hosseinzadeh, Hossein
TI Effects of alpha-mangostin on memory senescence induced by high glucose
   in human umbilical vein endothelial cells
SO IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
LA English
DT Article
DE Cellular senescence; Diabetes; Diabetes complications; Endothelial
   cells; Garcinia mangostana; Hyperglycemia; Mangostin; Metabolic syndrome
ID CELLULAR METABOLIC MEMORY; D-GALACTOSE; OXIDATIVE STRESS; CROCIN
AB Objective(s): Hyperglycemia induces cellular senescence in various body cells, such as vascular endothelial cells. Since the vessels are highly distributed in the body and nourish all tissues, vascular damages cause diabetes complications such as kidney failure and visual impairment. Alpha-mangostin is a xanthone found in mangosteen fruit with protective effects in metabolic syndrome and diabetes. This paper has investigated the protective effect of this xanthone against high glucose-induced memory senescence in human vascular endothelial cells (HUVECs) in the presence of metformin, as a positive control.
   Materials and Methods: To induce the memory senescence model, HUVECs, after three days incubation with high glucose, were incubated with normal glucose for another three days, and for whole six days, cells were treated with metformin (50 mu M) or alpha-mangostin (1.25 mu M). On the last day, cell viability by MTT assay, oxidative stress by fluorimetric assay, the number of senescent cells by SA beta-galactosidase staining kit, and secretory interleukin-6 by ELISA kit were measured. SIRT1 and P53 proteins were also evaluated by Western blotting.
   Results: Metformin and alpha-mangostin significantly increased cell viability, decreased reactive oxygen species, and senescence-associated beta-galactosidase in HUVECs incubated in metabolic memory condition. Generally, metabolic memory increased p53 and acetyl-P53 and decreased SIRT1 proteins in HUVECs, which were reversed by alpha-mangostin and metformin.
   Conclusion: These data exhibit that alpha-mangostin, comparable to metformin, protects endothelial cells against metabolic memory-induced senescence, which is likely via SIRT1.
C1 [Tousian, Hourieh; Razavi, Bibi Marian; Hosseinzadeh, Hossein] Mashhad Univ Med Sci, Sch Pharm, Dept Pharmacodynam & Toxicol, Mashhad, Razavi Khorasan, Iran.
   [Razavi, Bibi Marian] Mashhad Univ Med Sci, Targeted Drug Delivery Res Ctr, Pharmaceut Technol Inst, Mashhad, Razavi Khorasan, Iran.
   [Hosseinzadeh, Hossein] Mashhad Univ Med Sci, Pharmaceut Res Ctr, Pharmaceut Technol Inst, Mashhad, Razavi Khorasan, Iran.
C3 Mashhad University of Medical Sciences; Mashhad University of Medical
   Sciences; Mashhad University of Medical Sciences
RP Hosseinzadeh, H (corresponding author), Mashhad Univ Med Sci, Pharmaceut Res Ctr, Pharmaceut Technol Inst, Mashhad, Razavi Khorasan, Iran.
EM hosseinzadehh@mums.ac.ir
RI Hosseinzadeh, Hossein/F-3013-2010; tousian, hourieh/AAA-4820-2020;
   razavi, Bibi Marjan/AAY-5636-2020
OI razavi, Bibi Marjan/0000-0002-7450-9286; Tousian,
   Hourieh/0000-0001-7760-0301
FU Mashhad University of Medical Sciences, Mashhad, Iran [941389]
FX We thank the Research Vice-Chancellors of Mashhad University of Medical
   Sciences, Mashhad, Iran (Grant 941389), for financial support. The
   results described in this paper were part of a Pharmacy student thesis.
CR Arunachalam G, 2014, BRIT J PHARMACOL, V171, P523, DOI 10.1111/bph.12496
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NR 26
TC 6
Z9 6
U1 0
U2 4
PU MASHHAD UNIV MED SCIENCES
PI MASHHAD
PA VICE-CHANCELLOR FOR RES CTR OFF IJBMS, DANESHGAH ST, PO BOX 9138813944 -
   445, MASHHAD, 00000, IRAN
SN 2008-3866
EI 2008-3874
J9 IRAN J BASIC MED SCI
JI Iran. J. Basic Med. Sci.
PD OCT
PY 2020
VL 23
IS 10
BP 1261
EP 1267
DI 10.22038/ijbms.2020.40651.9612
PG 7
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA NX0ES
UT WOS:000575392900003
PM 33149857
DA 2025-06-11
ER

PT J
AU Nakatsu, Y
   Niida, S
   Tanaka, K
   Takenak, S
   Kuwabara, A
AF Nakatsu, Yuka
   Niida, Shumpei
   Tanaka, Kiyoshi
   Takenak, Shigeo
   Kuwabara, Akiko
TI The Relationship between Serum Vitamin E Level and Risk Factors for
   Arteriosclerosis in Japanese Postmenopausal Women
SO JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY
LA English
DT Article
DE antioxidant; alpha-tocopherol; insufficiency; metabolic syndrome;
   oxidative stress; serum lipids adjustment
ID METABOLIC SYNDROME; ALPHA-TOCOPHEROL; GAMMA-TOCOPHEROL; OXIDATIVE
   STRESS; ANTIOXIDANT CONCENTRATIONS; NATIONAL-HEALTH; DOUBLE-BLIND;
   SUPPLEMENTATION; ADULTS; ASSOCIATIONS
AB Since vitamin E is one of the most potent antioxidant and anti-inflammatory agents, vitamin E can play a role against arteriosclerosis through various actions. Then, we have studied the relationship between serum vitamin E status and risk factors for arteriosclerosis in Japanese postmenopausal women. One hundred and seven subjects (70.0 +/- 7.7 y) were evaluated for vitamin E status by measuring serum alpha- and gamma-tocopherol (alpha T and gamma T) levels. The number of arteriosclerosis risk factors was defined by the existence of high blood pressure, hyperglycemia, and dyslipidemia. Median serum alpha T and gamma T concentrations were 24.32 and 2.79 mu mol/L, respectively. In none of the subjects, serum alpha T level was below the cutoff value (<12 mu mol/L) for vitamin E deficiency which causes fragile erythrocyte and hemolysis. While no significant differences were found in serum levels of alpha T and gamma T between the groups categorized by the number of arteriosclerosis risks, serum levels of alpha T adjusted by serum total cholesterol (TC) and triglyceride (TG) decreased with an increasing number of arteriosclerotic risk factors (p= 0.074). Serum alpha T level adjusted by serum TC and TG was also a negative significant predictor for the number of arteriosclerosis risk factors controlled by covariates associated with arteriosclerosis. The present study described that serum vitamin E level was positively associated with a lower number of arteriosclerotic risks, and its role for preventing noncom municable diseases was suggested.
C1 [Nakatsu, Yuka; Takenak, Shigeo; Kuwabara, Akiko] Osaka Prefecture Univ, Grad Sch Comprehens Rehabil, Dept Clin Nutr, 3-7-30 Habikino, Habikino, Osaka 5838555, Japan.
   [Niida, Shumpei] Natl Ctr Geriatr & Gerontol, Med Genome Ctr, Obu 4748511, Japan.
   [Tanaka, Kiyoshi] Kobe Gakuin Univ, Fac Nutr, Kobe, Hyogo 6512180, Japan.
C3 Osaka Metropolitan University; National Center for Geriatrics &
   Gerontology; Kobe Gakuin University
RP Kuwabara, A (corresponding author), Osaka Prefecture Univ, Grad Sch Comprehens Rehabil, Dept Clin Nutr, 3-7-30 Habikino, Habikino, Osaka 5838555, Japan.
EM akuwabara@rehab.osakafu-u.ac.jp
FU JSPS KAKENHI [19K11747]; Grants-in-Aid for Scientific Research
   [19K11747] Funding Source: KAKEN
FX This work was supported by JSPS KAKENHI Grant Number 19K11747.
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NR 34
TC 2
Z9 3
U1 0
U2 1
PU CENTER ACADEMIC PUBL JAPAN
PI TOKYO
PA 2-4-16 YAYOI, BUNKYO-KU, TOKYO, 113-0032, JAPAN
SN 0301-4800
EI 1881-7742
J9 J NUTR SCI VITAMINOL
JI J. Nutr. Sci. Vitaminol.
PY 2020
VL 66
IS 3
BP 213
EP 218
DI 10.3177/jnsv.66.213
PG 6
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA MF4TQ
UT WOS:000545337100001
PM 32612082
OA gold
DA 2025-06-11
ER

PT J
AU Geetha, R
   Radika, MK
   Priyadarshini, E
   Bhavani, K
   Anuradha, CV
AF Geetha, Rajagopalan
   Radika, Mutulur Krishnamoorthy
   Priyadarshini, Emayavaramban
   Bhavani, Krishnamurthy
   Anuradha, Carani Venkatraman
TI RETRACTED: Troxerutin reverses fibrotic changes in the myocardium of
   high-fat high-fructose diet-fed mice (Retracted Article)
SO MOLECULAR AND CELLULAR BIOCHEMISTRY
LA English
DT Article; Retracted Publication
DE High-fat high-fructose diet; Metabolic syndrome; Oxidative stress;
   Cardiac dysfunction; Fibrosis; Troxerutin
ID LEFT-VENTRICULAR HYPERTROPHY; OXIDATION PROTEIN PRODUCTS; DEPENDENT
   ACTIVATION; INSULIN SENSITIVITY; REPERFUSION INJURY; DIABETES-MELLITUS;
   NADPH OXIDASE; STRESS; MATRIX; HEART
AB A previous study from our laboratory showed that troxerutin (TX) provides cardioprotection by mitigating lipid abnormalities in a high-fat high-fructose diet (HFFD)-fed mice model of metabolic syndrome (MS). The present study aims to investigate the reversal effect of TX on the fibrogenic changes in the myocardium of HFFD-fed mice. Adult male Mus musculus mice were grouped into four and fed either control diet or HFFD for 60 days. Each group was divided into two, and the mice were either treated or untreated with TX (150 mg/kg bw, p.o) from the 16th day. HFFD-fed mice showed marked changes in the electrocardiographic data. Increased levels of myocardial superoxide, p22phox subunit of NADPH oxidase, transforming growth factor (TGF), smooth muscle actin (alpha-SMA), and matrix metalloproteinases (MMPs)-9 and -2, and decreased levels of tissue inhibitors of MMPs-1 and -2 were observed. Furthermore, degradation products of troponin I and myosin light chain-1 were observed in the myocardium by immunoblotting. Rise in collagen was observed by hydroxyproline assay, while fibrotic changes were noticed by histology and Western blotting. Hypertrophy of cardiomyocytes and myocardial calcium accumulation were also observed in HFFD-fed mice. TX treatment exerted cardioprotective and anti-fibrotic effects in HFFD-fed mice by improving cardiac contractile function, reducing superoxide production and by favorably modifying the fibrosis markers. These findings suggest that TX could be cardioprotective through its antioxidant and antifibrogenic actions. This new finding could pave way for translation studies to human MS.
C1 [Geetha, Rajagopalan; Radika, Mutulur Krishnamoorthy; Priyadarshini, Emayavaramban; Anuradha, Carani Venkatraman] Annamalai Univ, Dept Biochem & Biotechnol, Chidambaram 608002, Tamil Nadu, India.
   [Bhavani, Krishnamurthy] Mahatma Gandhi Med Coll & Res Inst, Dept Pathol, Pondicherry, India.
C3 Annamalai University; Mahatma Gandhi Medical College & Research
   Institute
RP Anuradha, CV (corresponding author), Annamalai Univ, Dept Biochem & Biotechnol, Chidambaram 608002, Tamil Nadu, India.
EM cvaradha@hotmail.com
RI Venkatraman, Anuradha/U-8717-2019
OI Carani Venkatraman, Anuradha/0000-0001-9924-2533
FU Indian Council of Medical Research (ICMR), New Delhi
FX The first author Rajagopalan Geetha is thankful to the Indian Council of
   Medical Research (ICMR), New Delhi for awarding Senior Research
   Fellowship (SRF) to carry out this work.
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NR 59
TC 29
Z9 32
U1 0
U2 22
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0300-8177
EI 1573-4919
J9 MOL CELL BIOCHEM
JI Mol. Cell. Biochem.
PD SEP
PY 2015
VL 407
IS 1-2
BP 263
EP 279
DI 10.1007/s11010-015-2474-3
PG 17
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA CP3KX
UT WOS:000359778900025
PM 26077659
DA 2025-06-11
ER

PT J
AU Onat, A
   Köroglu, B
   Can, G
   Karagöz, A
   Yuksel, M
   Aydin, M
AF Onat, Altan
   Koroglu, Bayram
   Can, Gunay
   Karagoz, Ahmet
   Yuksel, Murat
   Aydin, Mesut
TI Apparently "low" serum asymmetric dimethylarginine is associated with
   fasting glucose and tends toward association with type-2 diabetes
SO ANATOLIAN JOURNAL OF CARDIOLOGY
LA English
DT Article
DE asymmetric dimethylarginine; diabetes type-2; glucose; oxidative stress;
   sex difference; regression analysis
ID CORONARY-ARTERY-DISEASE; ADVERSE CARDIOVASCULAR EVENTS; OXIDE SYNTHASE
   INHIBITOR; ENDOTHELIAL FUNCTION; METABOLIC SYNDROME; L-ARGININE;
   RHEUMATOID-ARTHRITIS; RENAL-DISEASE; RISK-FACTORS; TURKISH MEN
AB Objective: We investigated the association of serum asymmetric dimethylarginine (ADMA) with metabolic syndrome (MetS), type-2 diabetes and coronary heart disease (CHD) in the general population.
   Methods: Cross-sectional and, at 2000 person-years' follow-up, prospective analysis. Adults with measured serum ADMA level (n=848) were analyzed using tertiles or dichotomized values. ADMA concentrations were measured by a validated commercial ELISA kit.
   Results: Dichotomized subjects of combined sexes with low (<= 0.68 mu ol/L) ADMA values had significantly higher fasting glucose, total cholesterol, apolipoprotein B and lower diastolic blood pressure. In linear regression analyses comprising age, smoking, triglyceride, HDL-cholesterol, C-reactive protein and waist circumference as well, creatinine was significantly and independently associated with ADMA, further in women glucose (inversely). In logistic regression analyses uniformly adjusted for age, smoking status and waist girth, prevalent MetS tended to positive independent association with ADMA tertiles only in men. Combined prevalent and incident diabetes weakly tended to be associated with the lowest (vs mid-and highest) ADMA tertiles in combined gender; and prevalent and incident CHD was not associated with ADMA tertiles in either sex.
   Conclusion: Apparently "low" circulating ADMA is independently associated with fasting glucose and tends to be so with type-2 diabetes. The lack of anticipated positive associations of ADMA with cardiometabolic disorders is likely due to autoimmune responses operating against serum ADMA under oxidative stress, rendering partial failure in immunoassay.
C1 [Onat, Altan] Istanbul Univ, Cerrahpasa Fac Med, Turkish Soc Cardiol, Istanbul, Turkey.
   [Onat, Altan] Istanbul Univ, Cerrahpasa Fac Med, Dept Cardiol, Istanbul, Turkey.
   [Can, Gunay] Istanbul Univ, Cerrahpasa Fac Med, Dept Publ Hlth, Istanbul, Turkey.
   [Koroglu, Bayram] Siyami Ersek Ctr Cardiovasc Surg, Clin Cardiol, Istanbul, Turkey.
   [Karagoz, Ahmet] Numune Hosp, Clin Cardiol, Ankara, Turkey.
   [Yuksel, Murat; Aydin, Mesut] Dicle Univ, Fac Med, Dept Cardiol, Diyarbakir, Turkey.
C3 Istanbul University - Cerrahpasa; Turkish Heart Foundation; Istanbul
   University; Istanbul University; Istanbul University - Cerrahpasa;
   Istanbul University; Istanbul University - Cerrahpasa; Dr. Siyami Ersek
   Cardiac & Vascular Surgery Training & Research Hospital; Ankara Numune
   Training & Research Hospital; Dicle University
RP Onat, A (corresponding author), Nisbetiye Cad 59-24, TR-34335 Istanbul, Turkey.
EM alt_onat@yahoo.com.tr
RI Can, Günay/AAB-1669-2020; Yuksel, Murat/B-7287-2013; Karagöz,
   Ahmet/G-2175-2015
OI Yuksel, Murat/0000-0003-2636-5211
FU Turkish Adult Risk Factor surveys by the Turkish Society of Cardiology
FX We are grateful for the financial support of the Turkish Adult Risk
   Factor surveys over the years by the Turkish Society of Cardiology, and
   the various pharmaceutical companies in Istanbul.
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NR 39
TC 8
Z9 8
U1 0
U2 5
PU TURKISH SOC CARDIOLOGY
PI BAHCELIEVLER
PA COBANCESME SANAYI CAD NO 11, NISH ISTANBUL A BLOK KAT 8 NO 47-48,
   YENIBOSNA, BAHCELIEVLER, ISTANBUL 34196, TURKEY
SN 2149-2263
EI 2149-2271
J9 ANATOL J CARDIOL
JI Anat. J. Cardiol.
PD FEB
PY 2014
VL 14
IS 1
BP 26
EP 33
DI 10.5152/akd.2013.5009
PG 8
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA AK0LU
UT WOS:000338105200009
PM 24342929
DA 2025-06-11
ER

PT J
AU Schuppan, D
   Schattenberg, JM
AF Schuppan, Detlef
   Schattenberg, Jorn M.
TI Non-alcoholic steatohepatitis: Pathogenesis and novel therapeutic
   approaches
SO JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
LA English
DT Article; Proceedings Paper
CT 7th International Symposium on Alcoholic Liver and Pancreatic Diseases
   and Cirrhosis
CY SEP 06-07, 2012
CL Beijing, PEOPLES R CHINA
DE apoptosis; diabetes; DPP-4; fibrosis; FXR; GLP-1; lifestyle; metabolic
   syndrome; microbiome; NASH
ID FATTY LIVER-DISEASE; HEPATIC STEATOSIS; RISK-FACTORS; NATURAL-HISTORY;
   GLUCOSE-METABOLISM; INSULIN-RESISTANCE; PHYSICAL-ACTIVITY;
   UNITED-STATES; C57BL/6J MICE; DIET
AB Non-alcoholic fatty liver disease (NAFLD) refers to a disease spectrum, ranging from mere hepatic steatosis to hepatic necroinflammation (NASH, non-alcoholic steatohepatitis). NASH often leads to fibrosis, which can progress to cirrhosis with a high risk of liver failure and hepatocellular carcinoma. The course of NAFLD is highly variable, and only a minority of patients (2-3%) progress to end-stage liver disease. However, due to a dramatic increase of the risk factors for NAFLD, that is obesity and insulin resistance/type 2 diabetes, that affect 15-30% and 7-15% of subjects, in most industrialized countries, respectively, NAFLD has become the most frequent liver disease and is even considered a pace setter of the metabolic syndrome. Sedentary lifestyle, modern Western nutrition, and genetic predispositions have been identified as major causes of NAFLD. These lead to liver injury via insulin resistance and an excess of free fatty acids in hepatocytes, resulting in oxidant stress and lipotoxicity that promote the activation of intracellular stress kinases and apoptosis or necroapoptosis (NASH). The damaged hepatocytes directly trigger inflammation and fibrogenesis, but can also lead to the emergence of fibrogenic progenitor cells. Moreover, NASH is linked to inflammation in peripheral adipose tissues that involves mainly macrophages and humoral factors, such as adipokines and cytokines. The most efficient treatment is by weight loss and exercise, but (adjunctive) pharmacological strategies are urgently needed. Here, we highlight the aspects of NAFLD epidemiology and pathophysiology that are beginning to lead to novel pharmacological approaches to address this growing health-care challenge.
C1 [Schuppan, Detlef] Johannes Gutenberg Univ Mainz, D-55131 Mainz, Germany.
   [Schuppan, Detlef; Schattenberg, Jorn M.] Johannes Gutenberg Univ Mainz, Dept Med 1, Univ Med Ctr, D-55131 Mainz, Germany.
C3 Johannes Gutenberg University of Mainz; Johannes Gutenberg University of
   Mainz
RP Schuppan, D (corresponding author), Johannes Gutenberg Univ Mainz, Dept Med 1, Langenbeckstr 1, D-55131 Mainz, Germany.
EM detlef.schuppan@unimedizin-mainz.de
RI Schattenberg, Jörn/C-1301-2013; Schuppan, Detlef/AER-9743-2022
OI Schattenberg, Jorn M./0000-0002-4224-4703
FU NIH; European Union; State of Rhino-Palatinate; German Research
   Foundation; German Ministry of Education and Research;
   Boehringer-Ingelheim; DFG; University Medical Center Mainz
FX DS and JMS declare no conflicting interests. DS received funding from
   the NIH, European Union, the State of Rhino-Palatinate, the German
   Research Foundation, the German Ministry of Education and Research, and
   Boehringer-Ingelheim. JMS receives funding from the DFG and intramural
   funds of the University Medical Center Mainz.
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NR 92
TC 211
Z9 242
U1 0
U2 98
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0815-9319
EI 1440-1746
J9 J GASTROEN HEPATOL
JI J. Gastroenterol. Hepatol.
PD AUG
PY 2013
VL 28
SU 1
SI SI
BP 68
EP 76
DI 10.1111/jgh.12212
PG 9
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Gastroenterology & Hepatology
GA 286JB
UT WOS:000329463400013
PM 23855299
DA 2025-06-11
ER

PT J
AU Iwen, KAH
   Senyaman, O
   Schwartz, A
   Drenckhan, M
   Meier, B
   Hadaschik, D
   Klein, J
AF Iwen, K. Alexander H.
   Senyaman, Oezge
   Schwartz, Arne
   Drenckhan, Maren
   Meier, Britta
   Hadaschik, Dirk
   Klein, Johannes
TI Melanocortin crosstalk with adipose functions: ACTH directly induces
   insulin resistance, promotes a pro-inflammatory adipokine profile and
   stimulates UCP-1 in adipocytes
SO JOURNAL OF ENDOCRINOLOGY
LA English
DT Article
ID ACTIVATED PROTEIN-KINASE; PITUITARY-ADRENAL AXIS; BROWN ADIPOCYTES;
   SKELETAL-MUSCLE; 3T3-L1 ADIPOCYTES; ABDOMINAL OBESITY; LEPTIN SECRETION;
   GLUCOSE-UPTAKE; EXPRESSION; TISSUE
AB The melanocortin (MC) system is a pivotal component of the hypothalamo-pituitary-adrenal (HPA) stress axis and plays an important role in the pathogenesis of obesity and the metabolic syndrome. Adipose dysfunction is implicated in the pathogenesis of these disorders. We investigated direct ACTH effects on adipose functions in immortalised murine white and brown adipocytes. MC receptor types 2 and 5 were expressed at the mRNA and protein levels and were strongly up-regulated during differentiation. Chronic ACTH stimulation did not affect adipogenesis. Insulin-induced glucose uptake in white adipocytes was acutely and transiently reduced by 45% upon ACTH treatment. Visfatin and adiponectin gene expression was reduced by about 50% in response to ACTH, while interleukin-6 (IL-6) and monocyte chemoattractant protein-1 (MCP-1) mRNA levels were acutely tip-regulated by 2100 and 60% respectively. Moreover, IL-6 secretion was increased by 1450% within 4 h of ACTH treatment. In brown adipocytes, stimulation with ACTH caused a 690% increase in uncoupling protein (UCP)-1 mRNA levels within 8 h, followed by a 470% increase in UCP-1 protein concentrations after 24 h. Consistently, p38 mitogen-activated protein kinase (MAPK) phosphorylation was acutely increased by 1800% in response to ACTH stimulation, and selective inhibition of p38 MAPK abolished the ACTH-mediated UCP-1 protein increase. Taken together, ACTH acutely promotes an insulin-resistant, pro-inflammatory state and transiently enhances energy combustion. In conditions characterised by a dysregulation of the HPA stress axis such as the metabolic syndrome, direct MC interaction with adipocytes may contribute to dysregulated energy balance, insulin resistance and cardiometabolic complications.
C1 [Iwen, K. Alexander H.; Senyaman, Oezge; Schwartz, Arne; Drenckhan, Maren; Meier, Britta; Hadaschik, Dirk; Klein, Johannes] Med Univ Lubeck, Dept Internal Med 1, D-23538 Lubeck, Germany.
C3 University of Lubeck
RP Senyaman, O (corresponding author), Med Univ Lubeck, Dept Internal Med 1, Ratzeburger Allee 160, D-23538 Lubeck, Germany.
EM j.klein@uni-luebeck.de
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NR 42
TC 55
Z9 67
U1 0
U2 2
PU BIOSCIENTIFICA LTD
PI BRISTOL
PA EURO HOUSE, 22 APEX COURT WOODLANDS, BRADLEY STOKE, BRISTOL BS32 4JT,
   ENGLAND
SN 0022-0795
EI 1479-6805
J9 J ENDOCRINOL
JI J. Endocrinol.
PD MAR
PY 2008
VL 196
IS 3
BP 465
EP 472
DI 10.1677/JOE-07-0299
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 278PC
UT WOS:000254297800003
PM 18310442
DA 2025-06-11
ER

PT J
AU Maggi, M
   Schulman, C
   Quinton, R
   Langham, S
   Uhl-Hochgraeber, K
AF Maggi, Mario
   Schulman, Claude
   Quinton, Richard
   Langham, Sue
   Uhl-Hochgraeber, Kerstin
TI The burden of testosterone deficiency syndrome in adult men: Economic
   and quality-of-life impact
SO JOURNAL OF SEXUAL MEDICINE
LA English
DT Article
DE testosterone deficiency; cost of illness; quality of life; hypogonadism
ID BONE-MINERAL DENSITY; ANDROGEN RECEPTOR POLYMORPHISM; METABOLIC
   SYNDROME; ERECTILE DYSFUNCTION; KLINEFELTER-SYNDROME; HIP FRACTURE;
   ELDERLY-MEN; TRABECULAR ARCHITECTURE; DEPRESSIVE SYMPTOMS; REPLACEMENT
   THERAPY
AB Introduction. Testosterone deficiency syndrome (TDS) causes a wide range of symptoms that can lead to significant morbidity. Preliminary evidence has also linked TDS with premature mortality and with a number of comorbid diseases including diabetes and metabolic syndrome. Such associations can lead to substantial economic and quality- of-life implications, the magnitude of which remains largely unknown.
   Aim. To review the economic and quality-of-life consequences of a largely untreated condition and to consider the likely health economic benefits of testosterone treatment.
   Methods. A systematic review of four main areas: epidemiological evidence of the magnitude of TDS, estimates of cost of illness, impact on quality-of-life, and cost-effectiveness of testosterone treatment.
   Main Outcome Measure. Review of peer-reviewed literature.
   Results. The lack of clear universally accepted diagnostic criteria and the uncertainty surrounding the link between TDS and some of its consequences complicate the estimation of the burden of illness of TDS. Consequences of TDS that potentially lead to increased economic burden include depression, sexual dysfunction, mild cognitive impairment, osteoporosis, cardiovascular disease, and mortality. However, although good evidence exists demonstrating an association between TDS and sexual dysfunction and cognitive impairment, evidence is less strong for depression, the incidence of fractures and mortality, and highly controversial for cardiovascular disease. The consequences that are likely to impact on patients' quality of life include sexual function, energy levels, body composition, mood, and cognitive function.
   Conclusion. Understanding the burden is only the first step decision makers need to take to decide whether to allocate scarce resources to treat the condition. To make informed decisions on when and who to treat information is also needed on the cost-effectiveness of available treatments. Such data would highlight the benefits of treatment of TDS to physicians, patients, and to society as a whole.
C1 Univ Florence, Androl Unit, Dept Clin Physiopathol, I-50139 Florence, Italy.
   Free Univ Brussels, Erasme Hosp, Dept Urol, B-1050 Brussels, Belgium.
   Royal Victoria Infirm, Endocrine Unit, Newcastle Upon Tyne NE1 4LP, Tyne & Wear, England.
   Newcastle Univ, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England.
   Bayer Schering Pharma AG, Global Hlth Econ & Outcomes Res, Berlin, Germany.
C3 University of Florence; Universite Libre de Bruxelles; Newcastle
   University - UK; Newcastle University - UK; Bayer AG; Bayer Healthcare
   Pharmaceuticals
RP Maggi, M (corresponding author), Univ Florence, Androl Unit, Dept Clin Physiopathol, Viale Pieraccini 6, I-50139 Florence, Italy.
EM m.maggi@dfc.unifi.it
RI Maggi, Mario/AAB-8284-2019
OI MAGGI, Mario/0000-0003-3267-4221
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NR 95
TC 90
Z9 93
U1 0
U2 4
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1743-6095
EI 1743-6109
J9 J SEX MED
JI J. Sex. Med.
PD JUL
PY 2007
VL 4
IS 4
BP 1056
EP 1069
DI 10.1111/j.1743-6109.2007.00531.x
PN 1
PG 14
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Urology & Nephrology
GA 188MZ
UT WOS:000247925300026
PM 17627750
DA 2025-06-11
ER

PT J
AU Taliyan, R
   Chandra, SK
   Kakoty, V
AF Taliyan, Rajeev
   Chandra, Sarathlal K.
   Kakoty, Violina
TI Therapeutic Approaches to Alzheimer's Type of Dementia: A Focus on FGF21
   Mediated Neuroprotection
SO CURRENT PHARMACEUTICAL DESIGN
LA English
DT Review
DE Metabolic syndrome; insulin resistance; neurodegeneration; Alzheimer's
   disease; fibroblast growth factor 21; diabetes mellitus
ID CENTRAL-NERVOUS-SYSTEM; IMPROVES INSULIN SENSITIVITY; INDUCED COGNITIVE
   DEFICITS; AMYLOID-BETA PEPTIDE; A-BETA; MOUSE MODEL; INTRANASAL INSULIN;
   ENERGY-EXPENDITURE; MITOCHONDRIAL DYSFUNCTION; SIGNALING PATHWAY
AB Neurodegenerative disorders are the most devastating disorder of the nervous system. The pathological basis of neurodegeneration is linked with dysfunctional protein trafficking, mitochondrial stress, environmental factors and aging. With the identification of insulin and insulin receptors in some parts of the brain, it has become evident that certain metabolic conditions associated with insulin dysfunction like Type 2 diabetes mellitus (T2DM), dyslipidemia, obesity etc., are also known to contribute to neurodegeneration mainly Alzheimer's Disease (AD). Recently, a member of the fibroblast growth factor (FGF) superfamily, FGF21 has proved tremendous efficacy in diseases like diabetes mellitus, obesity and insulin resistance (IR). Increased levels of FGF21 have been reported to exert multiple beneficial effects in metabolic syndrome. FGF21 receptors are present in certain areas of the brain involved in learning and memory. However, despite extensive research, its function as a neuroprotectant in AD remains elusive. FGF21 is a circulating endocrine hormone which is mainly secreted by the liver primarily in fasting conditions. FGF21 exerts its effects after binding to FGFR1 and co-receptor, beta-klotho (KLB). It is involved in regulating energy via glucose and lipid metabolism. It is believed that aberrant FGF21 signalling might account for various anomalies like neurodegeneration, cancer, metabolic dysfunction etc. Hence, this review will majorly focus on FGF21 role as a neuroprotectant and potential metabolic regulator. Moreover, we will also review its potential as an emerging candidate for combating metabolic stress induced neurodegenerative abnormalities.
C1 [Taliyan, Rajeev; Chandra, Sarathlal K.; Kakoty, Violina] Birla Inst Technol & Sci, Dept Pharm, Pilani 333031, Rajasthan, India.
C3 Birla Institute of Technology & Science Pilani (BITS Pilani)
RP Taliyan, R (corresponding author), Birla Inst Technol & Sci, Dept Pharm, Pilani 333031, Rajasthan, India.
EM taliyanraja@gmail.com
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NR 163
TC 23
Z9 25
U1 1
U2 14
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1381-6128
EI 1873-4286
J9 CURR PHARM DESIGN
JI Curr. Pharm. Design
PY 2019
VL 25
IS 23
BP 2555
EP 2568
DI 10.2174/1381612825666190716101411
PG 14
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA JB0VV
UT WOS:000488276900005
PM 31333086
DA 2025-06-11
ER

PT J
AU Hosokawa, K
   Takata, T
   Sugihara, T
   Matono, T
   Koda, M
   Kanda, T
   Taniguchi, S
   Ida, A
   Mae, Y
   Yamamoto, M
   Iyama, T
   Fukuda, S
   Isomoto, H
AF Hosokawa, Kohshiro
   Takata, Tomoaki
   Sugihara, Takaaki
   Matono, Tomomitsu
   Koda, Masahiko
   Kanda, Tsutomu
   Taniguchi, Sosuke
   Ida, Ayami
   Mae, Yukari
   Yamamoto, Marie
   Iyama, Takuji
   Fukuda, Satoko
   Isomoto, Hajime
TI Ipragliflozin Ameliorates Endoplasmic Reticulum Stress and Apoptosis
   through Preventing Ectopic Lipid Deposition in Renal Tubules
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE SGLT2 inhibitor; ER stress; lipotoxicity; steatonephropathy; ectopic fat
   accumulation; NASH; NAFLD
ID CHRONIC KIDNEY-DISEASE; NONALCOHOLIC STEATOHEPATITIS; MOUSE;
   ACCUMULATION
AB Background: Chronic kidney disease (CKD) and non-alcoholic steatohepatitis (NASH) are major health burdens closely related to metabolic syndrome. A link between CKD and NASH has been assumed; however, the underlying mechanism is still unknown. Ectopic lipid deposition (ELD) in the hepatocyte results in endoplasmic reticulum (ER) stress, which plays an important role in the development of steatohepatitis. ELD is also assumed to play a role in the development of kidney injury. We aimed to investigate the role of ELD and ER stress in the development of CKD, and evaluate the efficacy of a sodium glucose cotransporter-2 inhibitor, ipragliflozin. Methods: Male FLS-ob/ob mice that closely imitate the pathophysiology of NASH were treated with vehicle or ipragliflozin. Metabolic characteristics, histology of the kidney, ER stress, and apoptotic signals were evaluated. Results: The serum triglyceride was significantly lower in mice treated with ipragliflozin. Ipragliflozin reduced ELD in renal tubules. Ipragliflozin also reduced the expression levels of GRP78 and CHOP, apoptotic cells, and interstitial fibrosis. Conclusions: ELD induced kidney injury through ER stress. Ipragliflozin improved the pathogenesis of CKD by reducing ELD and ER stress in NASH-model mice. Our results suggest ipragliflozin has therapeutic effect on CKD in NASH.
C1 [Hosokawa, Kohshiro; Takata, Tomoaki; Sugihara, Takaaki; Matono, Tomomitsu; Kanda, Tsutomu; Taniguchi, Sosuke; Ida, Ayami; Mae, Yukari; Yamamoto, Marie; Iyama, Takuji; Fukuda, Satoko; Isomoto, Hajime] Tottori Univ, Div Med & Clin Sci, Fac Med, Yonago, Tottori 6838504, Japan.
   [Koda, Masahiko] Hino Hosp, Tottori 6894504, Japan.
C3 Tottori University
RP Takata, T (corresponding author), Tottori Univ, Div Med & Clin Sci, Fac Med, Yonago, Tottori 6838504, Japan.
EM koh-pd0415@jcom.zaq.ne.jp; t-takata@tottori-u.ac.jp;
   sugitaka2002@gmail.com; tonox1976@gmail.com; masakoda89@yahoo.co.jp;
   tsutomu.kanda.s@gmail.com; sosuket@icloud.com;
   idaayami1991914@yahoo.co.jp; yuuchanfront@gmail;
   m-lili@cameo.plala.or.jp; raisei_ka_1227@yahoo.co.jp;
   maetasa@med.tottori-u.ac.jp; isomoto@med.tottori-u.ac.jp
RI Takata, Tomoaki/AAC-9506-2020
OI Takata, Tomoaki/0000-0003-2959-6015; Kanda, Tsutomu/0000-0003-0409-9258
CR Akazawa Y, 2018, J GASTROENTEROL, V53, P893, DOI 10.1007/s00535-018-1451-5
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NR 28
TC 38
Z9 42
U1 1
U2 9
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD JAN 1
PY 2020
VL 21
IS 1
AR 190
DI 10.3390/ijms21010190
PG 12
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA KO2KF
UT WOS:000515378000190
PM 31888083
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Bekyarova, GY
   Vankova, DG
   Madjova, VH
   Bekyarov, NA
   Salim, AS
   Ivanova, DG
   Stoeva, SM
   Gerova, DI
   Kiselova-Kaneva, YD
AF Bekyarova, Ganka Y.
   Vankova, Deyana G.
   Madjova, Valentina H.
   Bekyarov, Nicolai A.
   Salim, Ayshe S.
   Ivanova, Diana G.
   Stoeva, Stefka M.
   Gerova, Daniela I.
   Kiselova-Kaneva, Yoana D.
TI Association between Nfr2, HO-1, NF-kB Expression, Plasma ADMA, and
   Oxidative Stress in Metabolic Syndrome
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE Nrf2; NF-kB; HO-1; PBMC; plasma ADMA; oxidative stress; endothelial
   dysfunction
ID ASYMMETRIC DIMETHYLARGININE ADMA; HUMAN HEME OXYGENASE-1; ENDOTHELIAL
   DYSFUNCTION; CARDIOVASCULAR RISK; KAPPA-B; NRF2; INFLAMMATION;
   ACTIVATION; MECHANISMS; INDUCTION
AB Endothelial dysfunction is one of the major factors in the pathogenesis of metabolic syndrome (MetS), and its molecular mechanisms are not completely understood. The present study aimed to examine the connection between nuclear factor2-related factor2 (Nrf2), nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappa B), heme oxygenase 1 (HO-1), and plasma asymmetric dimethylarginine (ADMA) and malondialdehyde (MDA) in people with MetS. Participants in the study were as follows: with MetS (n = 30) and without MetS (Control) (n = 14). Expression of Nrf2, NF-kB, and HO-1 was measured in peripheral blood mononuclear cells (PBMCs). Plasma ADMA was determined using the ELISA technique and MDA via the thiobarbituric acid method. Our study showed that mRNA of NF-kB, Nrf2, and HO-1 levels in PBMCs in the MetS group were significantly higher than in the controls by 53%, 130%, and 185% (p < 0.05), respectively. Similarly, elevated levels of MDA (by 78%, p < 0.001) and ADMA (by 18.7%, p < 0.001) were established in the MetS group. Our findings show the importance of transcription factor Nrf2, playing an integral role in the protection of the endothelium, and of NF-kappa B, a transcription factor mediating the inflammatory response in MetS. Knowledge of complex cellular-molecular mechanisms would allow the use of biomarkers such as Nrf2, NF-kB, HO-1, and ADMA for the assessment of endothelial dysfunction in clinical practice.
C1 [Bekyarova, Ganka Y.] Med Univ Varna, Dept Physiol & Pathophysiol, Varna 9002, Bulgaria.
   [Vankova, Deyana G.; Salim, Ayshe S.; Ivanova, Diana G.; Stoeva, Stefka M.; Kiselova-Kaneva, Yoana D.] Med Univ Varna, Dept Biochem Mol Med & Nutrigen, Varna 9002, Bulgaria.
   [Madjova, Valentina H.; Bekyarov, Nicolai A.] Med Univ Varna, Dept Gen Med, Varna 9002, Bulgaria.
   [Gerova, Daniela I.] Med Univ Varna, Dept Clin Lab, Varna 9002, Bulgaria.
C3 Medical University Varna; Medical University Varna; Medical University
   Varna; Medical University Varna
RP Kiselova-Kaneva, YD (corresponding author), Med Univ Varna, Dept Biochem Mol Med & Nutrigen, Varna 9002, Bulgaria.
EM valentina.madjova@mu-varna.bg; ayshe.salim@mu-varna.bg;
   divanova@mu-varna.bg; stefka.stoeva@mu-varna.bg;
   yoana.kiselova@mu-varna.bg
RI Ivanova, Diana/JVY-8696-2024; Vankova, Deyana/MZQ-2229-2025
OI Ivanova, Diana/0000-0002-4502-081X; Salim, Ayshe/0000-0002-1422-7121;
   Kiselova-Kaneva, Yoana/0000-0001-9692-6227
FU European Union, NextGenerationEU
FX No Statement Available
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NR 53
TC 5
Z9 5
U1 2
U2 10
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD DEC
PY 2023
VL 24
IS 23
AR 17067
DI 10.3390/ijms242317067
PG 11
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA AH9Q0
UT WOS:001117695600001
PM 38069389
OA gold
DA 2025-06-11
ER

PT J
AU Mercurio, G
   Giacco, A
   Scopigno, N
   Vigliotti, M
   Goglia, F
   Cioffi, F
   Silvestri, E
AF Mercurio, Giovanna
   Giacco, Antonia
   Scopigno, Nicla
   Vigliotti, Michela
   Goglia, Fernando
   Cioffi, Federica
   Silvestri, Elena
TI Mitochondria at the Crossroads: Linking the Mediterranean Diet to
   Metabolic Health and Non-Pharmacological Approaches to NAFLD
SO NUTRIENTS
LA English
DT Review
DE mitochondrial bioenergetics; mitochondrial quality control; polyphenols;
   MUFA; PUFA; fructose; fatty liver; metabolic syndrome; lifestyle; MASLD
ID NONALCOHOLIC FATTY LIVER; DE-NOVO LIPOGENESIS; INSULIN-RESISTANCE; OLIVE
   OIL; HEPATIC STEATOSIS; ENERGY-METABOLISM; OBETICHOLIC ACID; OXIDATIVE
   STRESS; FOOD-PRODUCTS; DISEASE
AB Nonalcoholic fatty liver disease (NAFLD) is a growing global health concern that is closely linked to metabolic syndrome, yet no approved pharmacological treatment exists. The Mediterranean diet (MD) emerged as a first-line dietary intervention for NAFLD, offering metabolic and hepatoprotective benefits. Now conceptualized as a complex chemical matrix rich in bioactive compounds, the MD exerts antioxidant and anti-inflammatory effects, improving insulin sensitivity and lipid metabolism. Mitochondria play a central role in NAFLD pathophysiology, influencing energy metabolism, oxidative stress, and lipid homeostasis. Emerging evidence suggests that the MD's bioactive compounds enhance mitochondrial function by modulating oxidative phosphorylation, biogenesis, and mitophagy. However, most research has focused on individual compounds rather than the MD as a whole, leaving gaps in understanding its collective impact as a complex dietary pattern. This narrative review explores how the MD and its bioactive compounds influence mitochondrial health in NAFLD, highlighting key pathways such as mitochondrial substrate control, dynamics, and energy efficiency. A literature search was conducted to identify relevant studies on the MD, mitochondria, and NAFLD. While the search was promising, our understanding remains incomplete, particularly when current knowledge is limited by the lack of mechanistic and comprehensive studies on the MD's holistic impact. Future research integrating cutting-edge experimental approaches is needed to elucidate the intricate diet-mitochondria interactions. A deeper understanding of how the MD influences mitochondrial health in NAFLD is essential for developing precision-targeted nutritional strategies that can effectively prevent and manage the disease.
C1 [Mercurio, Giovanna; Giacco, Antonia; Scopigno, Nicla; Vigliotti, Michela; Goglia, Fernando; Cioffi, Federica; Silvestri, Elena] Univ Sannio, Dept Sci & Technol, Via Sanctis, I-82100 Benevento, Italy.
C3 University of Sannio
RP Silvestri, E (corresponding author), Univ Sannio, Dept Sci & Technol, Via Sanctis, I-82100 Benevento, Italy.
EM giomercurio@unisannio.it; antonia.giacco@unisannio.it;
   n.scopigno@studenti.unisannio.it; mvigliotti@unisannio.it;
   goglia@unisannio.it; fecioffi@unisannio.it; silvestri@unisannio.it
RI cioffi, federica/AAB-8161-2019
FU Nutraceutica, nutrigenomica e alimenti funzionali; ISTITUTO NEUROLOGICO
   MEDITERRANEO; Creazione di un programma di azione per la lotta alla
   malnutrizione in tutte le sue forme e per la diffusione dei principi
   della dieta mediterranea [CUP: F83C22002080008]
FX This research was funded by "Nutraceutica, nutrigenomica e alimenti
   funzionali", ISTITUTO NEUROLOGICO MEDITERRANEO "NEUROMED S.p.A",
   Traiettoria 5, Azione 5.1, << Creazione di un programma di azione per la
   lotta alla malnutrizione in tutte le sue forme e per la diffusione dei
   principi della dieta mediterranea >> -UOR UNISANNIO (CUP:
   F83C22002080008).
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NR 253
TC 0
Z9 0
U1 1
U2 1
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD MAR 30
PY 2025
VL 17
IS 7
AR 1214
DI 10.3390/nu17071214
PG 38
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 1FK2D
UT WOS:001463730300001
PM 40218971
DA 2025-06-11
ER

PT J
AU Ghaderi-Zefrehi, H
   Seif, F
   Niayesh-Mehr, R
   Ayashi, S
   Jafarirad, S
   Niknam, Z
   Rafiee, MH
   Babaahmadi-Rezaei, H
AF Ghaderi-Zefrehi, Hossein
   Seif, Faezeh
   Niayesh-Mehr, Reyhaneh
   Ayashi, Saleh
   Jafarirad, Sima
   Niknam, Zahra
   Rafiee, Mohammad Hessam
   Babaahmadi-Rezaei, Hossein
TI Impact of the supplementation of melatonin on oxidative stress marker
   and serum endothelin-1 in patients with metabolic syndrome
SO INTERNATIONAL JOURNAL OF DIABETES IN DEVELOPING COUNTRIES
LA English
DT Article
DE Cardiovascular diseases; Metabolic syndrome; Endothelin-1; Melatonin
ID BLOOD-PRESSURE; DOUBLE-BLIND; ANTIOXIDANT; PARAMETERS; PATHOPHYSIOLOGY;
   INFLAMMATION; THERAPY; OBESITY; INJURY; SYSTEM
AB ObjectiveMetabolic syndrome (MetS) is characterized by the cluster of risk factors associated with diabetes and cardiovascular diseases. Given the influential role of oxidative stress (OxS) in the pathogenesis of MetS and the antioxidant properties of melatonin, our study aims to investigate the impact of melatonin supplementation on OxS biomarkers and serum endothelin-1 (ET-1) levels in patients diagnosed with MetS.MethodsThis double-blind, placebo-controlled, randomized clinical trial involved male and female adult participants with MetS. Subjects in the melatonin and control groups were administered 6 mg/day of encapsulated powdered melatonin or placebo (wheat flour), respectively, over a 12-week period. We evaluated serum levels of malondialdehyde (MDA), superoxide dismutase (SOD) activity, and ET-1 in MetS patients, both pre- and post-intervention.ResultsMelatonin supplementation significantly decreased serum ET-1 level (1.55 +/- 0.24 pg/ml vs. 0.808 +/- 0.18 pg/ml; p = 0.04) and MDA (1.326 +/- 0.05 mu M vs. 1.134 +/- 0.05 mu M; p = 0.021) in the melatonin group relative to baseline values. Additionally, SOD activity displayed a significant increase (23.64 +/- 2.77 U/ml vs. 41.35 +/- 1.22 U/ml; p = 0.0001) in the melatonin group when compared to baseline.ConclusionOur research indicates that 12 weeks of melatonin supplementation in MetS patients leads to a significant reduction in serum ET-1 and MDA levels, alongside an increase in SOD activity levels relative to baseline. However, further comprehensive and well-structured randomized controlled trials are essential for establishing the effects of melatonin supplementation on OxS biomarkers in diverse age demographics.
C1 [Ghaderi-Zefrehi, Hossein; Niayesh-Mehr, Reyhaneh; Niknam, Zahra; Babaahmadi-Rezaei, Hossein] Ahvaz Jundishapur Univ Med Sci, Fac Med, Hyperlipidemia Res Ctr, Dept Clin Biochem, Ahvaz, Iran.
   [Seif, Faezeh] Shoushtar Sch Med Sci, Dept Sci, Shushtar, Iran.
   [Ayashi, Saleh] Abadan Sch Med Sci, Dept Clin Biochem, Abadan, Iran.
   [Jafarirad, Sima] Ahvaz Jundishapur Univ Med Sci, Fac Allied Med Sci, Nutr & Metab Dis Res Ctr, Dept Nutr Sci, Ahvaz, Iran.
   [Rafiee, Mohammad Hessam] High Inst Res & Educ Transfus Med, Blood Transfus Res Ctr, Tehran, Iran.
C3 Ahvaz Jundishapur University of Medical Sciences (AJUMS); Ahvaz
   Jundishapur University of Medical Sciences (AJUMS)
RP Babaahmadi-Rezaei, H (corresponding author), Ahvaz Jundishapur Univ Med Sci, Fac Med, Hyperlipidemia Res Ctr, Dept Clin Biochem, Ahvaz, Iran.
EM babaahmadi-h@ajums.ac.ir
RI seif, faezeh/AAZ-7423-2020; Rafiee, Mohammad/C-9808-2017;
   Babaahmadi-Rezaei, Hossein/D-3373-2013; Jafarirad, Sima/I-3688-2018
FU Ahvaz jundishapur University of Medical Sciences [HLRC-9612]
FX This study was financially supported by a grant No: HLRC-9612 from Ahvaz
   jundishapur University of Medical Sciences.
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NR 41
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER INDIA
PI NEW DELHI
PA 7TH FLOOR, VIJAYA BUILDING, 17, BARAKHAMBA ROAD, NEW DELHI, 110 001,
   INDIA
SN 0973-3930
EI 1998-3832
J9 INT J DIABETES DEV C
JI Int. Diabetes Dev. Ctries.
PD SEP
PY 2024
VL 44
IS 3
BP 619
EP 625
DI 10.1007/s13410-023-01266-5
EA OCT 2023
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA C0T0D
UT WOS:001097542800002
DA 2025-06-11
ER

PT J
AU Wahba, NS
   Abdel-Ghany, RH
   Ghareib, SA
   Abdel-Aal, M
   Alsemeh, AE
   Sabry, D
AF Wahba, Nehal S.
   Abdel-Ghany, Rasha H.
   Ghareib, Salah A.
   Abdel-Aal, Mohamed
   Alsemeh, Amira E.
   Sabry, Dina
TI Vitamin D3 potentiates the nephroprotective effects of
   vildagliptin-metformin combination in a rat model of metabolic syndrome
SO FUNDAMENTAL & CLINICAL PHARMACOLOGY
LA English
DT Article
DE DPP-4; SIRT1; AMPK; metformin; MetS-induced nephropathy; RAAS;
   vildagliptin; vitamin D3
ID DENSITY-LIPOPROTEIN CHOLESTEROL; RENIN-ANGIOTENSIN SYSTEM; BODY-FAT
   DISTRIBUTION; BETA-CELL FUNCTION; INSULIN-RESISTANCE; URIC-ACID;
   ADIPOSE-TISSUE; ADVANCED GLYCATION; SERUM ADIPONECTIN; OXIDATIVE STRESS
AB The current study was conducted to investigate the nephroprotective effects of vildagliptin-metformin combination in an experimental model of fructose/salt-induced metabolic syndrome (MetS). A major aim was to evaluate the potential capacity of vitamin D3 to potentiate the pleiotropic nephroprotective effects of vildagliptin-metformin combination. MetS was induced in adult male Wistar rats by adding fructose (10%) to everyday drinking water and salt (3%) to the diet for 6 weeks. Along with the same concentrations of fructose/salt feeding, MetS rats were then treated orally with either vildagliptin (10 mg/kg/day)-metformin (200 mg/kg/day) combination, vitamin D3 (10 mu g/kg/day), or the triple therapy for a further 6 weeks. The incidence of MetS was confirmed 6 weeks after fructose/salt consumption, when the rats exhibited significant weight gain, dyslipidemia, hyperuricemia, insulin resistance, hyperinsulinemia, and impaired glucose tolerance. At the end of the 12-week experimental period, MetS rats displayed significantly deteriorated renal function, enhanced intrarenal oxidative stress and inflammation together with exaggerated renal histopathological damages and interstitial fibrosis. The study has corroborated antioxidant, anti-inflammatory, and antifibrotic effects of vildagliptin-metformin combination, vitamin D3, and the triple collaborative therapy, conferring renoprotection in the setting of MetS. Due attention has been paid to the crucial role of dipeptidyl peptidase-4 inhibition and sirtuin-1/5 ' adenosine monophosphate-activated protein kinase activation as novel therapeutic targets to optimize renoprotection. The apparent potentiating effect, evoked upon coadministration of vitamin D3 with vildagliptin-metformin combination, may provide a cornerstone for further clinical investigations.
C1 [Wahba, Nehal S.; Abdel-Ghany, Rasha H.; Ghareib, Salah A.; Abdel-Aal, Mohamed] Zagazig Univ, Fac Pharm, Dept Pharmacol & Toxicol, Zagazig 44519, Egypt.
   [Alsemeh, Amira E.] Zagazig Univ, Fac Human Med, Dept Anat & Embryol, Zagazig, Egypt.
   [Sabry, Dina] Cairo Univ, Fac Med, Dept Med Biochem & Mol Biol, Cairo, Egypt.
   [Sabry, Dina] Badr Univ Cairo, Fac Med, Dept Med Biochem & Mol Biol, Badr City, Egypt.
C3 Egyptian Knowledge Bank (EKB); Zagazig University; Egyptian Knowledge
   Bank (EKB); Zagazig University; Egyptian Knowledge Bank (EKB); Cairo
   University; Badr University in Cairo
RP Wahba, NS (corresponding author), Zagazig Univ, Fac Pharm, Dept Pharmacol & Toxicol, Zagazig 44519, Egypt.
EM nehal.samir2011@yahoo.com
RI Wahba, Nehal/AAX-3271-2021; Alsemeh, Amira/LWH-9728-2024; abdalaal,
   mohamed/JGD-9871-2023; Atteiah, salah/I-1537-2012
OI Sabry, Dina/0000-0002-6720-3385; Ghareib, Salah/0009-0005-5718-321X;
   Wahba, Nehal/0000-0002-8637-9204
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NR 132
TC 2
Z9 2
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0767-3981
EI 1472-8206
J9 FUND CLIN PHARMACOL
JI Fundam. Clin. Pharmacol.
PD APR
PY 2022
VL 36
IS 2
BP 306
EP 323
DI 10.1111/fcp.12721
EA SEP 2021
PG 18
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA ZR6GE
UT WOS:000694949800001
PM 34453360
DA 2025-06-11
ER

PT J
AU Einvik, G
   Vistnes, M
   Hrubos-Strom, H
   Randby, A
   Namtvedt, SK
   Nordhus, IH
   Somers, VK
   Dammen, T
   Omland, T
AF Einvik, Gunnar
   Vistnes, Maria
   Hrubos-Strom, Harald
   Randby, Anna
   Namtvedt, Silje K.
   Nordhus, Inger H.
   Somers, Virend K.
   Dammen, Toril
   Omland, Torbjorn
TI Circulating cytokine concentrations are not associated with major
   depressive disorder in a community-based cohort
SO GENERAL HOSPITAL PSYCHIATRY
LA English
DT Article
DE Major depressive disorder; Inflammation; Cytokines; Obstructive sleep
   apnea; Beck Depression Inventory
ID OBSTRUCTIVE SLEEP-APNEA; CORONARY-HEART-DISEASE; C-REACTIVE PROTEIN;
   INFLAMMATION; PATHOPHYSIOLOGY; INTERLEUKIN-6; SYMPTOMS; RISK; TH2
AB Objective: The objective was to test the hypotheses that cytokine levels are elevated in community-residing persons at high risk for obstructive sleep apnea with major depressive disorder (MDD) compared to nondepressive persons and that cytokine levels show stronger correlations with somatic than psychological symptoms of depression.
   Method: A case control study within the cross-sectional Akershus Sleep Apnea Project was performed. Two controls matched for age, gender, metabolic syndrome and obstructive sleep apnea were drawn for each case of MDD.
   Results: Group comparisons revealed no significant difference in the levels of 17 cytokines [interleukin-1 beta -2,-4, -5, -6, -7, -8, -10, -12(p70), -13 and -17; tumor necrosis factor-alpha; interferon-gamma; granulocyte colony-stimulating factor; granulocyte monocyte colony-stimulating factor; macrophage chemoattractant protein-1 and monocyte inhibitory protein-1 beta] between persons with (n=34) and without MDD (n=68). There was no association between cytokines levels and MDD in multivariate regression analyses. The concentration of interleukin-4 was significantly more positively correlated with psychological than somatic symptoms (r=0.046 vs. -0.143, respectively, P=0.024), while no different correlations were observed for other cytokines.
   Conclusion: The cytokine levels were not elevated in MDD, and cytokine levels were not more strongly associated with somatic than psychological symptoms of depression. The depression-specific effect on inflammation may be weak in community-based samples with prevalent somatic comorbidity. (C) 2012 Elsevier Inc. All rights reserved.
C1 [Einvik, Gunnar; Randby, Anna; Namtvedt, Silje K.; Omland, Torbjorn] Akershus Univ Hosp, Div Med, N-1478 Lorenskog, Norway.
   [Einvik, Gunnar; Randby, Anna; Namtvedt, Silje K.; Omland, Torbjorn] Univ Oslo, Inst Clin Med, Oslo, Norway.
   [Vistnes, Maria] Oslo Univ Hosp, Expt Med Res Inst, Oslo, Norway.
   [Vistnes, Maria] Univ Oslo, KG Jebsen Cardiac Res Ctr, Oslo, Norway.
   [Vistnes, Maria] Univ Oslo, Ctr Heart Failure Res, Oslo, Norway.
   [Hrubos-Strom, Harald; Dammen, Toril] Univ Oslo, Dept Behav Med, Inst Basic Med Sci, Oslo, Norway.
   [Hrubos-Strom, Harald] Akershus Univ Hosp, Div Surg, Dept Otorhinolaryngol, N-1478 Lorenskog, Norway.
   [Nordhus, Inger H.] Univ Bergen, Dept Psychol, Bergen, Norway.
   [Somers, Virend K.] Mayo Clin, Dept Internal Med, Div Cardiovasc Dis, Rochester, MN USA.
   [Dammen, Toril] Oslo Univ Hosp Ulleval, Div Psychiat, Oslo, Norway.
C3 University of Oslo; University of Oslo; University of Oslo; University
   of Oslo; University of Oslo; University of Oslo; University of Oslo;
   University of Bergen; Mayo Clinic; University of Oslo
RP Einvik, G (corresponding author), Akershus Univ Hosp, Div Med, N-1478 Lorenskog, Norway.
EM gunnar.einvik@medisin.uio.no
OI Vistnes, Maria/0000-0002-6243-0626; Hrubos-Strom,
   Harald/0000-0003-0065-0145
FU regional health authority Helse Sor-Ost; University of Oslo
FX The study was supported by the regional health authority Helse Sor-Ost
   and the University of Oslo. Thanks for the statistical advices provided
   by Jurate Saltyte Benth, University of Oslo.
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NR 34
TC 27
Z9 33
U1 0
U2 3
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0163-8343
EI 1873-7714
J9 GEN HOSP PSYCHIAT
JI Gen. Hosp. Psych.
PD MAY-JUN
PY 2012
VL 34
IS 3
BP 262
EP 267
DI 10.1016/j.genhosppsych.2012.01.017
PG 6
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 944XR
UT WOS:000304237600008
PM 22401706
DA 2025-06-11
ER

PT J
AU El-Hafidi, M
   Franco, M
   Ramírez, AR
   Sosa, JS
   Flores, JAP
   Acosta, OL
   Salgado, MC
   Cardoso-Saldaña, G
AF El-Hafidi, Mohammed
   Franco, Martha
   Ruiz Ramirez, Angelica
   Santamaria Sosa, Jose
   Pineda Flores, Jose Antonio
   Lopez Acosta, Ocarol
   Chavez Salgado, Monserrath
   Cardoso-Saldana, Guillermo
TI Glycine Increases Insulin Sensitivity and Glutathione Biosynthesis and
   Protects against Oxidative Stress in a Model of Sucrose-Induced Insulin
   Resistance
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Article
ID FREE FATTY-ACIDS; LIVER-INJURY; BUTHIONINE SULFOXIMINE;
   SIGNAL-TRANSDUCTION; HEPATIC GLUTATHIONE; REACTIVE OXYGEN; FED RATS;
   IN-VIVO; DIET; CYSTEINE
AB Oxidative stress and redox status play a central role in the link between insulin resistance (IR) and lipotoxicity in metabolic syndrome. This mechanistic link may involve alterations in the glutathione redox state. We examined the effect of glycine supplementation to diet on glutathione biosynthesis, oxidative stress, IR, and insulin cell signaling in liver from sucrose- fed (SF) rats characterized by IR and oxidative stress. Our hypothesis is that the correction of glutathione levels by glycine treatment leads to reduced oxidative stress, a mechanism associated with improved insulin signaling and IR. Glycine treatment decreases the levels of oxidative stress markers in liver from SF rats and increases the concentrations of glutathione (GSH) and gamma-glutamylcysteine and the amount of gamma-glutamylcysteine synthetase (gamma-GCS), a key enzyme of GSH biosynthesis in liver from SF rats. In liver from SF rats, glycine also decreases the insulin-induced phosphorylation of insulin receptor substrate-1 (ISR-1) in serine residue and increases the phosphorylation of insulin receptor beta-subunit (IR-beta) in tyrosine residue. Thus, supplementing diets with glycine to correct GSH deficiency and to reduce oxidative stress provides significant metabolic benefits to SF rats by improving insulin sensitivity.
C1 [El-Hafidi, Mohammed; Ruiz Ramirez, Angelica; Pineda Flores, Jose Antonio; Lopez Acosta, Ocarol; Chavez Salgado, Monserrath] Inst Nacl Cardiol Ignacio Chavez, Dept Biomed Cardiovasc, Juan Badiano 1,Colonia Secc 16, Mexico City 14080, DF, Mexico.
   [Franco, Martha; Santamaria Sosa, Jose] Inst Nacl Cardiol Ignacio Chavez, Dept Nefrol, Juan Badiano 1,Colonia Secc 16, Mexico City 14080, DF, Mexico.
   [Cardoso-Saldana, Guillermo] Inst Nacl Cardiol Ignacio Chavez, Dept Endocrinol, Juan Badiano 1,Colonia Secc 16, Mexico City 14080, DF, Mexico.
C3 National Institute of Cardiology - Mexico; National Institute of
   Cardiology - Mexico; National Institute of Cardiology - Mexico
RP El-Hafidi, M (corresponding author), Inst Nacl Cardiol Ignacio Chavez, Dept Biomed Cardiovasc, Juan Badiano 1,Colonia Secc 16, Mexico City 14080, DF, Mexico.
EM medelhafidi@yahoo.com
RI Flores, José/T-7838-2018; El-Hafidi, Mohammed/AAN-4083-2021; Franco,
   Martha/H-2759-2017
FU CONACyT [106845]; Instituto de Ciencia y Tecnologia del Distrito
   Federal, Mexico City (ICyTDF) [PICDS08-67]
FX This work was supported in part by CONACyT (Grant no. 106845) and by
   Instituto de Ciencia y Tecnologia del Distrito Federal, Mexico City
   (ICyTDF) (Grant no. PICDS08-67).
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NR 48
TC 61
Z9 62
U1 2
U2 21
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PY 2018
VL 2018
AR 2101562
DI 10.1155/2018/2101562
PG 12
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA FX1RI
UT WOS:000425829100001
PM 29675131
OA Green Published, Green Submitted, hybrid
DA 2025-06-11
ER

PT J
AU Seematter, G
   Binnert, C
   Martin, JL
   Tappy, L
AF Seematter, G
   Binnert, C
   Martin, JL
   Tappy, L
TI Relationship between stress, inflammation and metabolism
SO CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE
LA English
DT Review
DE brain-derived neurotrophic factor; cortisol; epinephrine; insulin
   resistance; sympathetic nervous system
ID NECROSIS-FACTOR-ALPHA; INDUCED INSULIN-RESISTANCE; ACUTE MENTAL STRESS;
   ADIPOSE-TISSUE; COUNTERREGULATORY RESPONSES; ANTECEDENT HYPOGLYCEMIA;
   EUGLYCEMIC EXERCISE; NEUROTROPHIC FACTOR; ENERGY-EXPENDITURE; TNF-ALPHA
AB Purpose of review Various threatening stimuli, such as pain, low blood pressure, or infection, elicit a set of neuroendocrine responses that include an increased secretion of catecholamines and glucocorticoid from the adrenal gland and activation of the sympathetic nervous system. These hormonal secretions allow a 'fight or flight' response by mobilizing endogenous substrate. They also exert anti-insulin actions, and may in the long term induce a state of insulin resistance. In addition, stress stimulates inflammatory mediators in mononuclear cells. Given the possible role of low-grade inflammation in chronic metabolic disorders, this suggests that stress may be a factor in the development of insulin resistance and the metabolic syndrome.
   Recent findings Studies reviewed in this article cover: (1) the metabolic and haemodynamic effects of stress in healthy and insulin-resistant individuals; (2) the relationship between stress and inflammation and the role of the autonomic nervous system; and (3) some factors known to modulate the neuroendocrine responses to stress. Future perspectives, together with some hints regarding the role of neurotrophins such as brain-derived neurotrophic factor, are delineated.
   Summary Recent work performed in the field has indicated that stress may be a significant factor in the pathogenesis of metabolic disorders. Nutritional intervention or pharmacological agents targeted at modulating stress should be investigated.
C1 Univ Lausanne Hosp, Anesthesiol Serv, Lausanne, Switzerland.
   Univ Lausanne, Dept Physiol, Lausanne, Switzerland.
C3 University of Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV);
   University of Lausanne
RP Dept Physiol, 7 Rue Bugnon, CH-1005 Lausanne, Switzerland.
EM luc.tappy@physiol.unil.ch
RI Tappy, Luc/A-8911-2017
OI Tappy, Luc/0000-0001-8469-4692; Martin, Jean-Luc/0000-0002-5082-4687
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NR 51
TC 57
Z9 69
U1 0
U2 30
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1363-1950
EI 1473-6519
J9 CURR OPIN CLIN NUTR
JI Curr. Opin. Clin. Nutr. Metab. Care
PD MAR
PY 2004
VL 7
IS 2
BP 169
EP 173
DI 10.1097/00075197-200403000-00011
PG 5
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 804MT
UT WOS:000220303500010
PM 15075708
DA 2025-06-11
ER

PT J
AU Anderson, CD
   Upadhya, G
   Conzen, KD
   Jia, JL
   Brunt, EM
   Tiriveedhi, V
   Xie, Y
   Ramachandran, S
   Mohanakumar, T
   Davidson, NO
   Chapman, WC
AF Anderson, Christopher D.
   Upadhya, Gundumi
   Conzen, Kendra D.
   Jia, Jianlou
   Brunt, Elizabeth M.
   Tiriveedhi, Venkataswarup
   Xie, Yan
   Ramachandran, Sabarinathan
   Mohanakumar, Thalachallour
   Davidson, Nicholas O.
   Chapman, William C.
TI Endoplasmic Reticulum Stress Is a Mediator of Posttransplant Injury in
   Severely Steatotic Liver Allografts
SO LIVER TRANSPLANTATION
LA English
DT Article
ID ISCHEMIA-REPERFUSION INJURY; UNFOLDED PROTEIN RESPONSE; ER STRESS;
   INSULIN-RESISTANCE; HEPATIC STEATOSIS; TRANSPLANTATION; APOPTOSIS;
   DISEASE; MOUSE; CASPASE-11
AB Hepatic steatosis continues to present a major challenge in liver transplantation. These organs have been shown to have increased susceptibility to cold ischemia/reperfusion (CIR) injury in comparison with otherwise comparable lean livers; the mechanisms governing this increased susceptibility to CIR injury are not fully understood. Endoplasmic reticulum (ER) stress is an important link between hepatic steatosis, insulin resistance, and metabolic syndrome. In this study, we investigated ER stress signaling and blockade in the mediation of CIR injury in severely steatotic rodent allografts. Steatotic allografts from genetically leptin-resistant rodents had increased ER stress responses and increased markers of hepatocellular injury after liver transplantation into strain-matched lean recipients. ER stress response components were reduced by the chemical chaperone taurine-conjugated ursodeoxycholic acid (TUDCA), and this resulted in an improvement in the allograft injury. TUDCA treatment decreased nuclear factor kappa B activation and the proinflammatory cytokines interleukin-6 and interleukin-1 beta. However, the predominant response was decreased expression of the ER stress cell death mediator [CCAAT/enhancer-binding protein homologous protein (CHOP)]. Furthermore, activation of inflammation-associated caspase-11 was decreased, and this linked ER stress/CHOP to proinflammatory cytokine production after steatotic liver transplantation. These data confirm ER stress in steatotic allografts and implicate this as a mediating mechanism of inflammation and hepatocyte death in the steatotic liver allograft. Liver Transpl 17:189-200, 2011. (C) 2011 AASLD.
C1 [Anderson, Christopher D.; Upadhya, Gundumi; Conzen, Kendra D.; Jia, Jianlou; Tiriveedhi, Venkataswarup; Ramachandran, Sabarinathan; Mohanakumar, Thalachallour; Chapman, William C.] Washington Univ, Dept Surg, St Louis, MO 63110 USA.
   [Brunt, Elizabeth M.] Washington Univ, Dept Pathol & Immunol, St Louis, MO 63110 USA.
   [Xie, Yan; Davidson, Nicholas O.] Washington Univ, Dept Med, St Louis, MO 63110 USA.
C3 Washington University (WUSTL); Washington University (WUSTL); Washington
   University (WUSTL)
RP Anderson, CD (corresponding author), Washington Univ, Dept Surg, 660 S Euclid Ave,Campus Box 8109, St Louis, MO 63110 USA.
EM andersonc@wudosis.wustl.edu
OI Ramachandran, Sabarinathan/0000-0003-2239-8083; Chapman,
   William/0000-0002-0072-3239
FU American Society of Transplant Surgeons; National Institutes of Health
   [P30 DK056341-09, L30 DK082350, HL-38180, DK-56260, DK-52574]
FX This work was supported in part by the American Society of Transplant
   Surgeons/Astellas Faculty Development Award (to Christopher D. Anderson)
   and by the National Institutes of Health (grant P30 DK056341-09 and L30
   DK082350 to Christopher D. Anderson and grants HL-38180, DK-56260, and
   DK-52574 to Nicholas O. Davidson).
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NR 46
TC 42
Z9 45
U1 0
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1527-6465
EI 1527-6473
J9 LIVER TRANSPLANT
JI Liver Transplant.
PD FEB
PY 2011
VL 17
IS 2
BP 189
EP 200
DI 10.1002/lt.22220
PG 12
WC Gastroenterology & Hepatology; Surgery; Transplantation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery; Transplantation
GA 716YU
UT WOS:000287010200013
PM 21280192
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Shell, AL
   Crawford, CA
   Cyders, MA
   Hirsh, AT
   Stewart, JC
AF Shell, Aubrey L.
   Crawford, Christopher A.
   Cyders, Melissa A.
   Hirsh, Adam T.
   Stewart, Jesse C.
TI Depressive disorder subtypes, depressive symptom clusters, and risk of
   obesity and diabetes: A systematic review
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Review
DE Depression; Depressive disorder subtypes; Depressive symptom clusters;
   Atypical; Somatic symptoms; Obesity; Diabetes
ID BODY-MASS INDEX; INSULIN-RESISTANCE; MAJOR DEPRESSION; ATYPICAL
   FEATURES; CARDIOVASCULAR-DISEASE; RHEUMATOID-ARTHRITIS; METABOLIC
   SYNDROME; WEIGHT CHANGE; OLDER-ADULTS; FAT MASS
AB Background: Overlapping but divided literatures suggest certain depression facets may pose greater obesity and diabetes risk than others. Our objectives were to integrate the major depressive disorder (MDD) subtype and depressive symptom cluster literatures and to clarify which facets are associated with the greatest cardiometabolic disease risk. Methods: We conducted a systematic review of published studies examining associations of >= 2 MDD subtypes or symptom clusters with obesity or diabetes risk outcomes. We report which facets the literature is "in favor" of (i. e., having the strongest or most consistent results). Results: Forty-five articles were included. Of the MDD subtype-obesity risk studies, 14 were in favor of atypical MDD, and 8 showed similar or null associations across subtypes. Of the symptom cluster-obesity risk studies, 5 were in favor of the somatic cluster, 1 was in favor of other clusters, and 5 were similar or null. Of the MDD subtype-diabetes risk studies, 7 were in favor of atypical MDD, 3 were in favor of other subtypes, and 5 were similar or null. Of the symptom cluster-diabetes risk studies, 7 were in favor of the somatic cluster, and 5 were similar or null. Limitations: Limitations in study design, sample selection, variable measurement, and analytic approach in these literatures apply to this review. Conclusions: Atypical MDD and the somatic cluster are most consistently associated with obesity and diabetes risk. Future research is needed to establish directionality and causality. Identifying the depression facets conferring the greatest risk could improve cardiometabolic disease risk stratification and prevention programs.
C1 [Shell, Aubrey L.] Indiana Univ Hlth, Dept Psychiat, Indianapolis, IN USA.
   [Crawford, Christopher A.; Cyders, Melissa A.; Hirsh, Adam T.; Stewart, Jesse C.] Indiana Univ Indianapolis, Dept Psychol, 402 North Blackford St,LD 100E, Indianapolis, IN 46202 USA.
C3 Indiana University Health; IU Health University Hospital; Indiana
   University System; Indiana University Indianapolis
RP Stewart, JC (corresponding author), Indiana Univ Indianapolis, Dept Psychol, 402 North Blackford St,LD 100E, Indianapolis, IN 46202 USA.
EM jstew@iupui.edu
OI Cyders, Melissa/0000-0003-1990-8337
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NR 106
TC 4
Z9 4
U1 4
U2 12
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD MAY 15
PY 2024
VL 353
BP 70
EP 89
DI 10.1016/j.jad.2024.02.051
EA MAR 2024
PG 20
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA QA0S0
UT WOS:001218048500001
PM 38432462
DA 2025-06-11
ER

PT J
AU Bhargava, B
   Rao, PN
   Kulkarni, AV
   Vishnubhotla, R
   Pramod, N
   Anitha, CT
   Mahadev, K
AF Bhargava, Bharam
   Rao, Padaki Nagaraja
   Kulkarni, Anand V.
   Vishnubhotla, Ravikanth
   Pramod, Nanditha
   Anitha, Chandanadur Thippaiah
   Mahadev, Kalyankar
TI Prevalence of metabolic dysfunction-associated fatty liver disease among
   information technology employees in India
SO SCIENTIFIC REPORTS
LA English
DT Article
DE Liver disease; NAFLD; MAFLD; IT industry; Liver steatosis; Metabolic
   syndrome; Non-communicable disease
ID PRACTICE GUIDANCE; MANAGEMENT
AB The Information Technology (IT) sector is a leading industry that fuels India's economic growth. However, the work culture in this sector often promotes sedentary lifestyle, inadequate physical activity, and unhealthy dietary patterns which are risk factors for various non-communicable disease (NCD). This study aims to assess the prevalence of metabolic dysfunction-associated fatty liver disease (MAFLD) among IT employees and its association with behavioural and biological risk factors. This cross-sectional study involved 345 IT employees in Hyderabad, India, who responded to a questionnaire on their occupational sitting, shift work, stress, sleep duration, smoking, physical activity, and food habits. Anthropometric, biochemical, metabolic, and liver function parameters were evaluated. MAFLD was diagnosed using a Vibration-Controlled Transient Elastography FibroScan. Chi-square test and Spearman's rank correlation were performed to analyse the associations and correlations between risk factors. The median age of the employees was 38 years (34-43 years) with a body mass index (BMI) of 244 (70.72%) obese. Approximately, 248 (71.88%), 89 (25.80%), 241 (69.86%) and 131 (37.97%) of employees were found to sit for long hours at work, had shift work, sleep deprivation and stress, respectively. Almost 72 (20.87%) of IT employees had elevated fasting blood glucose (FBG) and 264 (76.52%) had high low-density lipoprotein (LDL-C). Metabolic Syndrome (MetS) was present in 118 (34.20%) of the employees. A total of 290 (84.06%) employees had increased liver fat accumulation indicating MAFLD. There is high prevalence of MAFLD among IT employees, highlighting the urgent need for workplace interventions and health promotion initiatives addressing MAFLD risk in the IT workforce.
C1 [Bhargava, Bharam; Pramod, Nanditha; Anitha, Chandanadur Thippaiah; Mahadev, Kalyankar] Univ Hyderabad, Sch Med Sci, Hyderabad, India.
   [Rao, Padaki Nagaraja; Kulkarni, Anand V.; Vishnubhotla, Ravikanth] Asian Inst Gastroenterol Hosp, Hyderabad, India.
C3 University of Hyderabad
RP Anitha, CT; Mahadev, K (corresponding author), Univ Hyderabad, Sch Med Sci, Hyderabad, India.
EM actmd@uohyd.ac.in; mkmd@uohyd.ac.in
OI Pramod, Nanditha/0009-0008-9004-5814
FU University of Hyderabad; Ministry of Education, Government of India;
   ICMR project [52/10/2020-BIO/BMS]
FX The University of Hyderabad provided resources such as infrastructure,
   library and logistics under the Institute of Eminence program of the
   Ministry of Education, Government of India. BB was the recipient of a
   non-NET fellowship from University of Hyderabad. NP is the recipient of
   Project Research Scientist-1 funds from the ICMR project (F. No.
   52/10/2020-BIO/BMS). The investigators would like to thank Dr. Barry J.
   Goldstein, former Vice-President-Drug Development, Labcorp Drug
   Development and Merck Company for critically reading the manuscript and
   providing comments. The investigators would like to thank Dr. Pramod
   Rajaram for discussion on statistics. The investigators would like to
   thank Mr. Amith Chaudhary, Mr. Danish Quamar and Mr. Govardhan for the
   recruitment of participants, collection of serum samples and all those
   who participated in this study.
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   WHO, STEPwise approach to NCD risk factor surveillance (STEPS)
NR 43
TC 0
Z9 0
U1 0
U2 0
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD MAR 24
PY 2025
VL 15
IS 1
AR 10124
DI 10.1038/s41598-025-91482-2
PG 14
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 0NA6U
UT WOS:001451257100031
PM 40128210
OA gold
DA 2025-06-11
ER

PT J
AU Banerjee, P
   Reddy, GB
   Panda, H
   Angadi, KK
   Reddy, T
   Gavaravarapu, SM
AF Banerjee, Paromita
   Reddy, G. Bhanuprakash
   Panda, Hrusikesh
   Angadi, Kiran Kumar
   Reddy, Thirupathi
   Gavaravarapu, SubbaRao M.
TI Diets, Lifestyles and Metabolic Risk Factors among Corporate Information
   Technology (IT) Employees in South India
SO NUTRIENTS
LA English
DT Article
DE employee health; workplace wellness
ID NONCOMMUNICABLE DISEASES; OCCUPATIONAL STRESS; ASSOCIATION; WORKPLACE;
   INTERVENTIONS; NUTRITION; BURNOUT
AB (1) Information Technology (IT) Business Process Outsourcing (BPO), the largest employment sector of India, contributes to rapid economic growth. However, the work of IT employees is sedentary, and the food environments of their worksites expose them to an obesogenic environment. This study aimed to assess their metabolic and lifestyle risk factors. (2) Methods: To examine the health and nutrition status of IT employees, anthropometric, biochemical and clinical assessments were conducted among 183 employees from three IT organizations of varied operational sizes. Their health-, diet- and physical activity-related practices were assessed using a questionnaire. The prevalence of MetS was assessed. Selected biomarker levels were assessed and associated with their self-perceived stress levels. (3) Results: The median age of the employees was 30 years (26-35 years). While 44.02% of employees were overweight, 16.85% of employees were obese. About 3.89% of employees were found to be diabetic, and HDL-C levels were lower than recommended in 64.93% of employees. In all, 29.87% of the study population were considered to have metabolic syndrome since they had metabolic risk scores & GE; 3. Those with metabolic syndrome were significantly older (p = 0.000), and levels of MDA (p = 0.003), homocysteine (p = 0.001), IL-6 (p = 0.017) and IL-4 (p = 0.000) were significantly higher among them. Although the prevalence of MetS was significantly lower among those aged >30 years, the lifestyle risk factors were significantly higher among them. (4) Conclusions: The assessed parameters indicate a high risk of developing NCDs among employees in the IT industry in India. This shows the need for the modification of lifestyle and workplace food and physical activity environments.
C1 [Banerjee, Paromita; Panda, Hrusikesh; Reddy, Thirupathi; Gavaravarapu, SubbaRao M.] ICMR Natl Inst Nutr, Nutr Informat Commun & Hlth Educ NICHE Div, Hyderabad 500007, Telangana, India.
   [Reddy, G. Bhanuprakash; Angadi, Kiran Kumar] ICMR Natl Inst Nutr, Biochem Div, Hyderabad 500007, Telangana, India.
C3 Indian Council of Medical Research (ICMR); ICMR - National Institute of
   Nutrition (NIN); Indian Council of Medical Research (ICMR); ICMR -
   National Institute of Nutrition (NIN)
RP Gavaravarapu, SM (corresponding author), ICMR Natl Inst Nutr, Nutr Informat Commun & Hlth Educ NICHE Div, Hyderabad 500007, Telangana, India.
EM paromitabanerjee0806@gmail.com; geereddy@yahoo.com; hrusinin@gmail.com;
   dr.kirankumarangadi@gmail.com; thirupathireddy2423@gmail.com;
   subbarao.gm@icmr.gov.in
RI Mokalla, Thirupathi Reddy/AEE-3952-2022; Reddy, G.
   Bhanuprakash/AAJ-3494-2020; BANERJEE, PAROMITA/AIE-2822-2022
OI Reddy, G. Bhanuprakash/0000-0003-4787-3944; BANERJEE,
   PAROMITA/0000-0001-7122-8561; Reddy Mokalla,
   Thirupathi/0000-0002-6329-7206
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NR 45
TC 5
Z9 5
U1 0
U2 1
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD AUG
PY 2023
VL 15
IS 15
AR 3404
DI 10.3390/nu15153404
PG 14
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA O7NA5
UT WOS:001045621600001
PM 37571341
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Facca, TA
   Mastroianni-Kirsztajn, G
   Sabino, ARP
   Passos, MT
   dos Santos, LF
   Famá, EAB
   Nishida, SK
   Sass, N
AF Facca, Thais Alquezar
   Mastroianni-Kirsztajn, Gianna
   Pereira Sabino, Amelia Rodrigues
   Passos, Michelle Tiveron
   dos Santos, Larissa Fatima
   Brosco Fama, Eduardo Augusto
   Nishida, Sonia Kiyomi
   Sass, Nelson
TI Pregnancy as an early stress test for cardiovascular and kidney disease
   diagnosis
SO PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR
   HEALTH
LA English
DT Article
DE Hypertension; Obesity; Hypertension pregnancy-induced; Kidney diseases;
   Cardiovascular diseases
ID BLOOD-PRESSURE; RISK-FACTORS; LATER LIFE; PREECLAMPSIA; HYPERTENSION;
   WOMEN; MANAGEMENT; DISORDERS; OBESITY
AB Objectives: Pregnancy is a cardiometabolic and renal stress test for women, primarily when associated with hypertension syndrome, which can have deleterious effects in the long term. We undertook this study to make a long-term evaluation on these women.
   Study design: A retrospective cohort study was conducted to investigate voluntary women who had pregnancyinduced hypertension syndrome versus normal pregnancy.
   Main outcome measures: We evaluated a total of 85 women, divided in case (n= 25) and control (n= 60) groups, by clinical, anthropometric and epidemiological profiles, general, metabolic and renal tests, and risk stratification for cardiovascular disease (CVD) and chronic kidney disease (CKD).
   Results: The case group showed a higher incidence of hypertension (P = .003), shorter period between its diagnosis and end of pregnancy (P < .001) and lower age at diagnosis (P = .033); higher weight (P < .001), body mass index (BMI) (P < .001), waist-to-height ratio (p = .001) and abdominal circumference (P < .001); higher fat percentage (P =. 004) and weight to lose (P < .001) as measured by bioimpedance; lower estimate glomerular filtration rate (eGFR) by the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation (P =. 021), greater difference between estimated vascular age and real age (P=.008) according to Framingham Risk Score (2008) and higher frequency of metabolic syndrome (P < .001).
   Conclusions: Women who had pregnancy-induced hypertension syndrome were found with a higher incidence of obesity, metabolic syndrome and hypertension, earlier onset of hypertension, higher estimated vascular age and lower eGFR. These findings reinforce the importance of investigating the history of hypertension syndrome in pregnancy, which should be considered an indicator to be followed long term after childbirth.
C1 [Mastroianni-Kirsztajn, Gianna; Pereira Sabino, Amelia Rodrigues; Passos, Michelle Tiveron; dos Santos, Larissa Fatima; Nishida, Sonia Kiyomi] Dept Med, Div Nephrol, Sao Paulo, SP, Brazil.
   [Facca, Thais Alquezar; Brosco Fama, Eduardo Augusto; Sass, Nelson] Fed Univ Sao Paulo UNIFESP, Obstet, Sao Paulo, Brazil.
C3 Universidade Federal de Sao Paulo (UNIFESP)
RP Facca, TA; Mastroianni-Kirsztajn, G (corresponding author), Rua Botucatu 740,2 Andar Vila Clementino, BR-04023900 Sao Paulo, SP, Brazil.
EM tafacca@unifesp.br; gianna@nefro.epm.br
RI facca, thais/M-8499-2018; Sass, Nelson/E-3252-2013; Mastroianni
   Kirsztajn, Gianna/D-9596-2013
OI Mastroianni Kirsztajn, Gianna/0000-0003-1317-4109; Facca,
   Thais/0000-0003-2858-5584; Fama, Eduardo Augusto
   Brosco/0000-0001-6150-7276
FU FAPESP (Foundation for Research Support of the State of Sao Paulo)
   [2014/00213-7]; Fundacao de Amparo a Pesquisa do Estado de Sao Paulo
   (FAPESP) [14/00213-7] Funding Source: FAPESP
FX This research received Grant from FAPESP (Foundation for Research
   Support of the State of Sao Paulo) 2014/00213-7.
CR [Anonymous], PAN INS AL AM LAT CA
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NR 32
TC 21
Z9 22
U1 0
U2 3
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 2210-7789
J9 PREGNANCY HYPERTENS
JI Pregnancy Hypertens.
PD APR
PY 2018
VL 12
BP 169
EP 173
DI 10.1016/j.preghy.2017.11.008
PG 5
WC Obstetrics & Gynecology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology; Cardiovascular System & Cardiology
GA GH5BB
UT WOS:000433429700029
PM 29198741
DA 2025-06-11
ER

PT J
AU Oyama, J
   Yamamoto, H
   Maeda, T
   Ito, A
   Node, K
   Makino, N
AF Oyama, Jun-ichi
   Yamamoto, Hiroaki
   Maeda, Toyoki
   Ito, Akira
   Node, Koichi
   Makino, Naoki
TI Continuous Positive Airway Pressure Therapy Improves Vascular
   Dysfunction and Decreases Oxidative Stress in Patients With the
   Metabolic Syndrome and Obstructive Sleep Apnea Syndrome
SO CLINICAL CARDIOLOGY
LA English
DT Article
ID C-REACTIVE PROTEIN; MIDDLE-AGED MEN; ENDOTHELIAL DYSFUNCTION;
   CARDIOVASCULAR OUTCOMES; RESISTANCE; HYPEREMIA; DISEASE; HYPERTENSION;
   ASSOCIATION; ACTIVATION
AB Background: Patients with obstructive sleep apnea syndrome (OSAS) are always exposed to intermittent hypoxia and reoxygenation. The metabolic syndrome (MetS) and OSAS are also known to accelerate atherosclerosis, diabetes, and dyslipidemia. Therefore, nasal continuous positive airway pressure (CPAP) therapy may have beneficial effects in patients with the MetS and OSAS.
   Hypothesis: This study in patients with the MetS and OSAS tested the validity of the hypothesis that chronic CPAP therapy improves factors involved in atherosclerosis, including impaired endothelial function. Methods: Thirty-two patients (19 males and 13 females, mean age 54 +/- 9 y) diagnosed with theMetS and OSAS were enrolled in the study and received CPAP therapy for 3 months. Vascular function was investigated by measuring forearm blood flow (FBF) responses to reactive hyperemia (RH) using venous occlusion strain-gauge plethysmography. Biochemical markers were also measured before and after this procedure.
   Results: Basal apnea-hypopnea index was statistically correlated with FBF response to RH. The FBF response to RH was increased significantly after 3 months of CPAP therapy. A significant increase in plasma nitric oxide levels and a decrease in the levels of asymmetrical dimethylarginine, thiobarbituric acid reactive substance, soluble Fas ligand, and soluble CD40 ligand were detected after CPAP therapy. The plasma concentrations of tumor necrosis factor-alpha, interleukin (IL)-6, and IL-8 also decreased significantly with CPAP therapy, whereas IL-1 beta levels remained unchanged.
   Conclusions: Continuous positive airway pressure therapy has beneficial effects on vascular function and inflammatory and oxidative stress in patients with the MetS and OSAS.
C1 [Oyama, Jun-ichi; Maeda, Toyoki; Makino, Naoki] Kyushu Univ, Dept Cardiovasc Resp & Geriatr Med, Kyushu Univ Hosp Beppu, Oita, Japan.
   Kyushu Univ, Med Inst Bioregulat, Oita, Japan.
   [Oyama, Jun-ichi; Node, Koichi] Saga Univ, Dept Cardiovasc Med, Saga 840, Japan.
   [Yamamoto, Hiroaki; Ito, Akira] Gakkentoshi Clin, Fukuoka, Japan.
C3 Kyushu University; Kyushu University; Saga University
RP Oyama, J (corresponding author), Kyushu Univ, Dept Cardiovasc Resp & Geriatr Med, Kyushu Univ Hosp Beppu, 4546 Tsurumihara, Beppu, Oita 8740838, Japan.
EM joyama@tsurumi.beppu.kyushu-u.ac.jp
FU Grants-in-Aid for Scientific Research [23590885] Funding Source: KAKEN
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NR 28
TC 69
Z9 77
U1 1
U2 16
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0160-9289
EI 1932-8737
J9 CLIN CARDIOL
JI Clin. Cardiol.
PD APR
PY 2012
VL 35
IS 4
BP 231
EP 236
DI 10.1002/clc.21010
PG 6
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 922JI
UT WOS:000302542800007
PM 22278815
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU DeSantis, AS
   DiezRoux, AV
   Hajat, A
   Golden, SH
   Jenny, NS
   Sanchez, BN
   Shea, S
   Seeman, TE
AF DeSantis, A. S.
   DiezRoux, A. V.
   Hajat, A.
   Golden, S. H.
   Jenny, N. S.
   Sanchez, B. N.
   Shea, S.
   Seeman, T. E.
TI Associations of Salivary Cortisol Levels with Metabolic Syndrome and Its
   Components: The Multi-Ethnic Study of Atherosclerosis
SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Article
ID INSULIN-RESISTANCE; ABDOMINAL OBESITY; BLOOD-PRESSURE; STRESS;
   RESPONSES; PROFILES; RISK
AB Context: Prior research has identified associations between social-environmental factors and metabolic syndrome (MetS) components. The physiological mechanisms underlying these associations are not fully understood, but alterations in activity of the hypothalamic-pituitary-adrenal axis, a stress-responsive biological system, have been hypothesized to play a role.
   Objective: The aim of the study was to determine whether MetS diagnosis and specific clusters of MetS components (waist circumference, high-density lipoproteins, glucose, and blood pressure) are associated with cortisol levels.
   Design and Setting: We conducted cross-sectional analyses of data from the Multi-Ethnic Study of Atherosclerosis (MESA) study in the general community.
   Patients or Other Participants: We studied a population-based sample of 726 adults (ages 48 to 89 yr) who do not have clinical diabetes.
   Intervention(s): There were no interventions.
   Main Outcome Measure(s): Cortisol awakening response, cortisol decline across the waking day, and total cortisol output were analyzed (using 18 timed measures of salivary cortisol over 3 d).
   Results: Overall, we found little evidence that the presence of MetS or its components is related to cortisol output or patterns. Contrary to expectation, the presence of MetS was associated with lower rather than higher area under the curve, and no consistent pattern was observed when MetS components or subsets of components were examined in relation to cortisol.
   Conclusions: Our findings do not support the hypothesis that differences in level or diurnal pattern of salivary cortisol output are associated with MetS among persons without clinical diabetes. (J Clin Endocrinol Metab 96: 3483-3492, 2011)
C1 [DeSantis, A. S.; DiezRoux, A. V.; Hajat, A.] Univ Michigan, Ctr Social Epidemiol & Populat Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA.
   [Golden, S. H.] Johns Hopkins Univ, Dept Med Endocrinol, Dept Epidemiol, Baltimore, MD 21205 USA.
   [Jenny, N. S.] Univ Vermont, Dept Pathol, Coll Med, Burlington, VT 05405 USA.
   [Sanchez, B. N.] Univ Michigan, Dept Biostat, Ann Arbor, MI 48109 USA.
   [Shea, S.] Columbia Univ, Dept Epidemiol, Coll Phys & Surg, New York, NY 10032 USA.
   [Seeman, T. E.] Univ Calif Los Angeles, Dept Epidemiol, Dept Med, Los Angeles, CA 90095 USA.
C3 University of Michigan System; University of Michigan; Johns Hopkins
   University; University of Vermont; University of Michigan System;
   University of Michigan; Columbia University; University of California
   System; University of California Los Angeles
RP DeSantis, AS (corresponding author), Univ Michigan, Ctr Social Epidemiol & Populat Hlth, Dept Epidemiol, 1415 Washington Hts,SPH Tower 1, Ann Arbor, MI 48109 USA.
EM amydes@umich.edu
OI Hajat, Anjum/0000-0001-8807-9232; Sanchez, Brisa/0000-0002-4824-7200
FU National Heart, Lung, and Blood Institute (NHLBI) [N01-HC-95159,
   N01-HC-95169]; National Institutes of Health [1R01HL101161, R21
   DA024273]; National Center for Minority Health and Health Disparities of
   the National Institutes of Health [P60 MD002249]
FX MESA was supported by contracts N01-HC-95159 through N01-HC-95169 from
   the National Heart, Lung, and Blood Institute (NHLBI). NHLBI had no
   further role in the study design; in the collection, analysis, and
   interpretation of data; in the writing of the report; or in the decision
   to submit the paper for publication. The MESA Stress Study was supported
   by additional National Institutes of Health Grants 1R01HL101161 and R21
   DA024273. This work was also partly supported by the National Center for
   Minority Health and Health Disparities of the National Institutes of
   Health Grant P60 MD002249.
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NR 36
TC 38
Z9 40
U1 0
U2 8
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0021-972X
EI 1945-7197
J9 J CLIN ENDOCR METAB
JI J. Clin. Endocrinol. Metab.
PD NOV
PY 2011
VL 96
IS 11
BP 3483
EP 3492
DI 10.1210/jc.2011-0483
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 844MF
UT WOS:000296750600054
PM 21880797
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Bye, A
   Langaas, M
   Hoydal, MA
   Kemi, OJ
   Heinrich, G
   Koch, LG
   Britton, SL
   Najjar, SM
   Ellingsen, O
   Wisloff, U
AF Bye, Anja
   Langaas, Mette
   Hoydal, Morten A.
   Kemi, Ole Johan
   Heinrich, Garrett
   Koch, Lauren G.
   Britton, Steven L.
   Najjar, Sonia M.
   Ellingsen, Oyvind
   Wisloff, Ulrik
TI Aerobic capacity-dependent differences in cardiac gene expression
SO PHYSIOLOGICAL GENOMICS
LA English
DT Article
DE metabolic syndrome; metabolism; hypoxia; VO2max; hypertrophy
ID ENDURANCE RUNNING CAPACITY; COLONY-STIMULATING FACTOR; FATTY-ACID
   OXIDATION; HEART-FAILURE; ARTIFICIAL SELECTION; ENERGY-METABOLISM;
   RISK-FACTORS; RATS; HYPERTROPHY; MYOCYTES
AB Aerobic capacity is a strong predictor of cardiovascular mortality. To determine the relationship between inborn aerobic capacity and cardiac gene expression we examined genome-wide gene expression in hearts of rats artificially selected for high and low running capacity (HCR and LCR, respectively) over 16 generations. The artificial selection of LCR caused accumulation of risk factors of cardiovascular disease similar to the metabolic syndrome seen in human, whereas HCR had markedly better cardiac function. We also studied alterations in gene expression in response to exercise training in these animals. Left ventricle gene expression of both sedentary and exercise-trained HCR and LCR was characterized by microarray and gene ontology analysis. Out of 28,000 screened genes, 1,540 were differentially expressed between sedentary HCR and LCR. Only one gene was found differentially expressed by exercise training, but this gene had unknown name and function. Sedentary HCR expressed higher amounts of genes involved in lipid metabolism, whereas sedentary LCR expressed higher amounts of the genes involved in glucose metabolism. This suggests a switch in cardiac energy substrate utilization from normal mitochondrial fatty acid beta-oxidation in HCR to carbohydrate metabolism in LCR, an event that often occurs in diseased hearts. LCR were also associated with pathological growth signaling and cellular stress. Hypoxic conditions seemed to be a common source for several of these observations, triggering hypoxia-induced alterations of transcription. In conclusion, inborn high vs. low aerobic capacity was associated with differences in cardiac energy substrate, growth signaling, and cellular stress.
C1 [Bye, Anja; Hoydal, Morten A.; Ellingsen, Oyvind] Norwegian Univ Sci & Technol, Dept Circulat & Med Imaging, N-7034 Trondheim, Norway.
   [Langaas, Mette] Norwegian Univ Sci & Technol, Dept Math Sci, N-7034 Trondheim, Norway.
   [Kemi, Ole Johan] Univ Glasgow, Inst Biomed & Life Sci, Glasgow, Lanark, Scotland.
   [Heinrich, Garrett; Najjar, Sonia M.] Univ Toledo, Dept Pharmacol Cardiovasc Biol & Metab Dis, Toledo, OH USA.
   [Koch, Lauren G.; Britton, Steven L.] Univ Michigan, Med Ctr, Dept Phys Med & Rehabil, Ann Arbor, MI 48109 USA.
C3 Norwegian University of Science & Technology (NTNU); Norwegian
   University of Science & Technology (NTNU); University of Glasgow;
   University System of Ohio; University of Toledo; University of Michigan
   System; University of Michigan
RP Wisloff, U (corresponding author), Medisink Tekn Forkningssenter, N-7489 Trondheim, Norway.
EM Ulrik.Wisloff@ntnu.no
RI Koch, Lauren/D-1258-2010; Langaas, Mette/G-7423-2012; Wisloff,
   Ulrik/K-2899-2012; Bye, Anja/K-8041-2019; najjar, sonia/GXW-2217-2022;
   Hoydal, Morten/K-2806-2012
OI najjar, sonia/0000-0001-6209-8902; Kemi, Ole Johan/0000-0003-1344-9512;
   Wisloff, Ulrik/0000-0002-7211-3587; Langaas, Mette/0000-0002-5714-0288;
   Hoydal, Morten/0000-0003-1804-2578; Bye, Anja/0000-0003-1259-5542
FU NCRR NIH HHS [RR-17718] Funding Source: Medline
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NR 55
TC 31
Z9 42
U1 0
U2 8
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 1094-8341
EI 1531-2267
J9 PHYSIOL GENOMICS
JI Physiol. Genomics
PD MAR 14
PY 2008
VL 33
IS 1
BP 100
EP 109
DI 10.1152/physiolgenomics.00269.2007
PG 10
WC Cell Biology; Genetics & Heredity; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Genetics & Heredity; Physiology
GA 314ON
UT WOS:000256818800012
PM 18171719
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Holterman, AX
   Browne, A
   Dillard, BE
   Tussing, L
   Gorodner, V
   Stahl, C
   Browne, N
   Labott, S
   Herdegen, J
   Guzman, G
   Rink, A
   Nwaffo, I
   Galvani, C
   Horgan, S
   Holterman, M
AF Holterman, Ai-Xuan
   Browne, Allen
   Dillard, Barney E., III
   Tussing, Lisa
   Gorodner, Veronica
   Stahl, Christiane
   Browne, Nancy
   Labott, Sue
   Herdegen, James
   Guzman, Grace
   Rink, Andy
   Nwaffo, Ifeoma
   Galvani, Carlos
   Horgan, Santiago
   Holterman, Mark
TI Short-term outcome in the first 10 morbidly obese adolescent patients in
   the FDA-approved trial for laparoscopic adjustable gastric banding
SO JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
LA English
DT Article
DE laparoscopic adjustable gastric banding; LAP-BAND; adolescent obesity;
   bariatric surgery; comorbidities; health-related quality of life
ID NONALCOHOLIC FATTY LIVER; QUALITY-OF-LIFE; INSULIN-RESISTANCE; BARIATRIC
   SURGERY; SEVERELY OBESE; WEIGHT-LOSS; US EXPERIENCE; OVERWEIGHT;
   CHILDHOOD; CHILDREN
AB Background: We received the LAP-BAND Investigational Device Exemption (IDE) from the US Food and Drug Administration in December 2004 to conduct a prospective longitudinal trial examining the safety and efficacy of laparoscopic adjustable gastric banding (LAGB) in morbidly obese adolescents ages 14 to 17 years.
   Objectives: To report the short-term results of LAGB in the first 10 adolescents with complete 9 months of follow-up.
   Patients and Methods: Baseline characteristics and outcome data were analyzed in 10 patients enrolled between March 2005 and February 2006.
   Results: All of the patients were girls. Their mean body mass 2 index (+/- SD) was 50 +/- 13 kg/m(2) and excess weight was 171 +/- 79 pounds. Comorbidities included depression (3 patients), sleep apnea (3), hypertension (6), dyslipidemia (7), insulin resistance (9), metabolic syndrome (9), and steatoliepatitis (in 4 of 5 patients with liver biopsy). Operative time was 45 +/- 9 minutes, and discharges were within 23 hours of surgery. Band-related complications were as follows: 2 dehydration, 1 pouch dilation, and I port revision. All of the patients lost weight, with a 9-month excess weight loss of 30% 16% (range 14%57%). Hypertension and the metabolic syndrome were resolved in 100% of patients (P = 0.04) and 80% of the patients (P = 0.01), respectively, along with significant improvement in the Pediatric Quality of Life and Beck Depression Inventory scores and a trend toward improvement in high-density lipoprotein cholesterol abnormalities (P = 0.08).
   Conclusions: At short-term follow-up, weight loss occurred with minimal complications, leading to early resolution of major obesity-related comorbidities. Continued evaluation of the long-term safety and efficacy of LAGB as a surgical adjunct to a comprehensive obesity treatment program is warranted. JPGN 45:465-473, 2007.
C1 Univ Illinois, Div Pediat Surg, Dept Surg, Chicago, IL 60680 USA.
   Univ Illinois, New Hope Pediat & Adolescent Weight Management Pr, Chicago, IL 60680 USA.
   Univ Illinois, Div Gen Surg & Minimally Invas Surg, Dept Surg, Chicago, IL 60680 USA.
   Univ Illinois, Dept Pediat, Chicago, IL 60680 USA.
   Univ Illinois, Dept Psychiat, Chicago, IL 60680 USA.
   Univ Illinois, Ctr Sleep & Ventilatory Disorders, Sect Pulm Crit Care & Sleep Med, Dept Med, Chicago, IL 60680 USA.
   Univ Illinois, Dept Pathol, Chicago, IL 60680 USA.
C3 University of Illinois System; University of Illinois Chicago;
   University of Illinois Chicago Hospital; University of Illinois System;
   University of Illinois Chicago; University of Illinois Chicago Hospital;
   University of Illinois System; University of Illinois Chicago;
   University of Illinois Chicago Hospital; University of Illinois System;
   University of Illinois Chicago; University of Illinois Chicago Hospital;
   University of Illinois System; University of Illinois Chicago;
   University of Illinois Chicago Hospital; University of Illinois System;
   University of Illinois Chicago; University of Illinois Chicago Hospital;
   University of Illinois System; University of Illinois Chicago;
   University of Illinois Chicago Hospital
RP Holterman, AX (corresponding author), 840 S Wood St,Suite 416 M C 958, Chicago, IL 60612 USA.
EM aithanh@uic.edu
RI Browne, Allen/ABC-9684-2020; Browne, Nancy/AFU-2851-2022
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NR 43
TC 44
Z9 49
U1 0
U2 7
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0277-2116
EI 1536-4801
J9 J PEDIATR GASTR NUTR
JI J. Pediatr. Gastroenterol. Nutr.
PD OCT
PY 2007
VL 45
IS 4
BP 465
EP 473
DI 10.1097/MPG.0b013e318063eef6
PG 9
WC Gastroenterology & Hepatology; Nutrition & Dietetics; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Nutrition & Dietetics; Pediatrics
GA 212OQ
UT WOS:000249607100013
PM 18030214
OA Bronze
DA 2025-06-11
ER

PT J
AU Congur, I
   Mingrone, G
   Guan, KM
AF Congur, Irem
   Mingrone, Geltrude
   Guan, Kaomei
TI Targeting endoplasmic reticulum stress as a potential therapeutic
   strategy for diabetic cardiomyopathy
SO METABOLISM-CLINICAL AND EXPERIMENTAL
LA English
DT Article
DE ER stress; Insulin; Leptin; Lipotoxicity; Mitochondria-associated ER
   membrane; Diabetic cardiomyopathy
ID ER STRESS; INSULIN SENSITIVITY; CHEMICAL CHAPERONES; MEDIATED APOPTOSIS;
   METABOLIC SYNDROME; LEPTIN RESISTANCE; ENERGY-BALANCE; CELLS PROTECTS;
   ADIPOSE-TISSUE; POMC NEURONS
AB Endoplasmic reticulum (ER) is an essential organelle involved in vesicular transport, calcium handling, protein synthesis and folding, and lipid biosynthesis and metabolism. ER stress occurs when ER homeostasis is disrupted by the accumulation of unfolded and/or misfolded proteins in the ER lumen. Adaptive pathways of the unfolded protein response (UPR) are activated to maintain ER homeostasis. In obesity and type 2 diabetes mellitus (T2DM), accumulating data indicate that persistent ER stress due to maladaptive UPR interacts with insulin/ leptin signaling, which may be the potential and central mechanistic link between obesity-/T2DM-induced metabolic dysregulation (chronic hyperglycemia, dyslipidemia and lipotoxicity in cardiomyocytes), insulin/ leptin resistance and the development of diabetic cardiomyopathy (DiabCM). Meanwhile, these pathological conditions further exacerbate ER stress. However, their interrelationships and the underlying molecular mechanisms are not fully understood. A deeper understanding of ER stress-mediated pathways in DiabCM is needed to develop novel therapeutic strategies. The aim of this review is to discuss the crosstalk between ER stress and leptin/insulin signaling and their involvement in the development of DiabCM focusing on mitochondriaassociated ER membranes and chronic inflammation. We also present the current direction of drug development and important considerations for translational research into targeting ER stress for the treatment of DiabCM.
C1 [Congur, Irem; Guan, Kaomei] Tech Univ Dresden, Inst Pharmacol & Toxicol, Fetscherstr 74, D-01307 Dresden, Germany.
   [Mingrone, Geltrude] Kings Coll London, Sch Cardiovasc & Metab Med & Sci, Div Diabet & Nutr Sci, London, England.
   [Mingrone, Geltrude] Univ Cattolica Sacro Cuore, Rome, Italy.
   [Mingrone, Geltrude; Guan, Kaomei] Fdn Policlin Univ A Gemelli IRCCS, Dept Med & Surg Sci, Rome, Italy.
C3 Technische Universitat Dresden; University of London; King's College
   London; Catholic University of the Sacred Heart; IRCCS Policlinico
   Gemelli; Catholic University of the Sacred Heart; IRCCS Policlinico
   Gemelli
RP Guan, KM (corresponding author), Tech Univ Dresden, Inst Pharmacol & Toxicol, Fetscherstr 74, D-01307 Dresden, Germany.
EM kaomei.guan@tu-dresden.de
RI Congur, Irem/IAR-7246-2023
OI CONGUR, IREM/0000-0002-0414-3346
FU Deutsche Forschungsgemeinschaft (DFG) [288034826-IRTG2251]
FX IC was financially supported by the Deutsche Forschungsgemeinschaft
   (DFG) under project number 288034826-IRTG2251: "Immunological and
   Cellular Strategies in Metabolic Disease" for project 10 to GM and KG.
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NR 137
TC 3
Z9 3
U1 11
U2 12
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0026-0495
EI 1532-8600
J9 METABOLISM
JI Metab.-Clin. Exp.
PD JAN
PY 2025
VL 162
AR 156062
DI 10.1016/j.metabol.2024.156062
EA NOV 2024
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA M8P6K
UT WOS:001360100200001
PM 39515414
DA 2025-06-11
ER

PT J
AU Ferramosca, A
   Moscatelli, N
   Di Giacomo, M
   Zara, V
AF Ferramosca, A.
   Moscatelli, N.
   Di Giacomo, M.
   Zara, V.
TI Dietary fatty acids influence sperm quality and function
SO ANDROLOGY
LA English
DT Article
DE high-fat diet; male infertility; metabolic syndrome; sperm mitochondria
ID SEMEN QUALITY; MITOCHONDRIAL RESPIRATION; OXIDATIVE STRESS;
   MALE-INFERTILITY; LIVER-DISEASE; OLIVE OIL; HEPATIC LIPOGENESIS;
   MEDITERRANEAN DIET; METABOLIC SYNDROME; HUMAN SPERMATOZOA
AB Recently, obesity has been linked to male infertility. In animal models the administration of a high-fat diet caused a reduction in sperm quality, by impairing gamete energy metabolism. The aim of this study was to investigate a possible effect of dietary fatty acids supplementation in the modulation of sperm energy metabolism and, in turn, in the improvement of sperm quality in rats fed a high-fat diet. Sexually mature male Sprague-Dawley rats were divided into four groups and fed for 4weeks a standard diet (control group), a high-fat diet (enriched in 35% of fat and 15% sucrose), a high-fat diet supplemented with 2.5% olive oil (a source of monounsaturated fatty acids) or a high-fat diet supplemented with 2.5% krill oil (a source of n-3 polyunsaturated fatty acids). Liver and adipose tissue weight, plasma glucose, insulin and lipid concentrations were determined. Activities of enzymes involved in sperm energetic metabolism were evaluated by spectrophotometric assays. Sperm mitochondrial respiratory efficiency was also assayed. The obtained results suggest that olive oil partially counteracts the negative effects of a high-fat diet on sperm quality, by increasing gamete motility, by reducing oxidative stress and slightly improving mitochondrial respiration efficiency. On the other hand, krill oil determines an increase in sperm concentration and motility, an increase in the activities of lactate dehydrogenase, Krebs cycle enzymes and respiratory chain complexes; a parallel increase in the cellular levels of ATP and a reduction in oxidative damage were also observed. These results suggest that dietary fatty acids are able to positively influence sperm quality and function.
C1 [Ferramosca, A.; Moscatelli, N.; Di Giacomo, M.; Zara, V.] Univ Salento, Dipartimento Sci & Tecnol Biol & Ambientali, Via Prov Lecce Monteroni, I-73100 Lecce, Italy.
   [Ferramosca, A.; Moscatelli, N.] Ist Italiano Tecnol, Ctr Biomol Nanotechnol UNILE, Arnesano, LE, Italy.
C3 University of Salento; Istituto Italiano di Tecnologia - IIT; Center for
   Biomolecular Nanotechnologies IIT
RP Ferramosca, A (corresponding author), Univ Salento, Dipartimento Sci & Tecnol Biol & Ambientali, Via Prov Lecce Monteroni, I-73100 Lecce, Italy.
EM alessandra.ferramosca@unisalento.it
RI Zara, Vincenzo/AAC-2900-2019; Ferramosca, Alessandra/B-8801-2015
OI Di Giacomo, Mariangela/0000-0002-2082-7836; MOSCATELLI,
   NATALINA/0000-0002-9291-9588; Zara, Vincenzo/0000-0001-6592-4501;
   Ferramosca, Alessandra/0000-0002-8251-9652
FU Fondazione Cassa di Risparmio di Puglia
FX This research was financially supported by Fondazione Cassa di Risparmio
   di Puglia, regarding the project 'Obesita e infertilita maschile: ruolo
   degli acidi grassi nella modulazione del metabolismo energetico degli
   spermatozoi'.
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NR 45
TC 48
Z9 50
U1 1
U2 19
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2047-2919
EI 2047-2927
J9 ANDROLOGY-US
JI Andrology
PD MAY
PY 2017
VL 5
IS 3
BP 423
EP 430
DI 10.1111/andr.12348
PG 8
WC Andrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA ES6FV
UT WOS:000399642700007
PM 28334508
OA Bronze
DA 2025-06-11
ER

PT J
AU Isik, S
   Kiliç, S
   Ögretmen, Z
   Çakir, DÜ
   Türkön, H
   Cevizci, S
   Hiz, MM
AF Isik, Selda
   Kilic, Sevilay
   Ogretmen, Zerrin
   Cakir, Dilek Ulker
   Turkon, Hakan
   Cevizci, Sibel
   Hiz, Meliha Merve
TI The correlation between the psoriasis area severity index and
   ischemia-modified albumin, mean platelet volume levels in patients with
   psoriasis
SO POSTEPY DERMATOLOGII I ALERGOLOGII
LA English
DT Article
DE psoriasis; ischemia-modified albumin; mean platelet volume; psoriasis
   area severity index
ID METABOLIC SYNDROME; CARDIOVASCULAR-DISEASE; OXIDATIVE STRESS;
   ASSOCIATION; BIOMARKERS; ACTIVATION; NECROSIS; BINDING; LIPIDS
AB Introduction: Ischemia-modified albumin (IMA), a novel ischemia marker, and mean platelet volume (MPV), a determinant of platelet activation, have been reported as elevated markers in cardiovascular risk factors such as atherosclerosis, metabolic syndrome, diabetes mellitus (DM), hypertension, and dyslipidemia. As psoriasis is a chronic inflammatory disease having comorbidities, IMA and MPV can help determine the risk factors for psoriasis.
   Aim: To investigate the correlation between the psoriasis area severity index (PASO, IMA and MPV levels in patients with psoriasis.
   Material and methods: This cross-sectional, case-control study was performed between January 2014 and December 2014 at the University hospital in Canakkale, Turkey. Forty-five patients with psoriasis and 44 healthy volunteers over 18 years of age were included in the study. In the psoriasis patient group, clinical features and PASI scores were recorded. Serum IMA and MPV concentrations were evaluated in both groups.
   Results: The mean IMA values were 0.85 +/- 0.15 and 0.79 +/- 0.09 (in the psoriasis patients and control groups, respectively), and there was a statistically significant difference (p = 0.048). Ischemia-modified albumin levels were not correlated with PASI scores (r = 0.024; p = 0.889) but were correlated with disease duration (r = 0.323; p = 0.048). There was no statistically significant difference between the MPV values of the two groups (8.98 +/- 1.14 and 9.19 +/- 1.28 in the psoriasis patients and control groups, respectively) (p = 0.435).
   Conclusions: Ischemia-modified albumin may be used as a marker for detecting oxidative stress in patients with psoriasis, especially those with a long disease duration.
C1 [Isik, Selda; Kilic, Sevilay; Ogretmen, Zerrin] Canakkale Onsekiz Mart Univ, Fac Med, Dept Dermatol, TR-17100 Canakkale, Turkey.
   [Cakir, Dilek Ulker; Turkon, Hakan] Canakkale Onsekiz Mart Univ, Fac Med, Dept Biochem, Canakkale, Turkey.
   [Cevizci, Sibel] Canakkale Onsekiz Mart Univ, Fac Med, Dept Publ Hlth, Canakkale, Turkey.
   [Hiz, Meliha Merve] Canakkale Onsekiz Mart Univ, Fac Arts & Sci, Dept Biol, Canakkale, Turkey.
C3 Canakkale Onsekiz Mart University; Canakkale Onsekiz Mart University;
   Canakkale Onsekiz Mart University; Canakkale Onsekiz Mart University
RP Kiliç, S (corresponding author), Canakkale Onsekiz Mart Univ, Fac Med, Dept Dermatol, TR-17100 Canakkale, Turkey.
EM sevilay.oguz@gmail.com
RI ışık mermutlu, selda/JVZ-0089-2024; HIZ, Meliha Merve/AFM-3576-2022;
   Kılıç, Sevilay/AAK-4705-2020
OI HIZ, Meliha Merve/0000-0003-4303-9717
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NR 24
TC 21
Z9 22
U1 0
U2 15
PU TERMEDIA PUBLISHING HOUSE LTD
PI POZNAN
PA KLEEBERGA ST 2, POZNAN, 61-615, POLAND
SN 1642-395X
J9 POSTEP DERM ALERGOL
JI Postep. Dermatol. Alergol.
PY 2016
VL 33
IS 4
BP 290
EP 293
DI 10.5114/ada.2016.61606
PG 4
WC Allergy; Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Allergy; Dermatology
GA DU7QY
UT WOS:000382410900009
PM 27605901
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Bonomo, R
   Kramer, S
   Aubert, VM
AF Bonomo, Raiza
   Kramer, Sarah
   M. Aubert, Virginie
TI Obesity-Associated Neuropathy: Recent Preclinical Studies and Proposed
   Mechanisms
SO ANTIOXIDANTS & REDOX SIGNALING
LA English
DT Review
DE neuropathy; obesity; treatments; molecular mechanism; peripheral nerve
   system
ID GENE-RELATED PEPTIDE; DIABETIC PERIPHERAL NEUROPATHY;
   ENDOPLASMIC-RETICULUM STRESS; METABOLIC SYNDROME; CALCIUM HOMEOSTASIS;
   NERVE DYSFUNCTION; RISK-FACTORS; FATTY-ACIDS; ER STRESS; PAIN
AB Significance: The prevalence of metabolic syndrome (MetS) and associated obesity has increased in recent years, affecting millions worldwide. One of the most common complications of obesity is damage to the peripheral nerve system, referred to as neuropathy. The lack of disease-modifying therapy for this complication is largely due to a poor understanding of the complex neurobiology underlying neuropathy. Recent preclinical studies suggest that in addition to glucotoxic events, other mechanisms, including lipid signaling, microbiome, or inflammation, may be viable targets to prevent nerve damage and neuropathic pain in obesity.Recent Advances: Clinical and preclinical studies using diet-induced obesity rodent models have identified novel interventions that improve neuropathy. Notably, mechanistic studies suggest that lipid, calcium signaling, and inflammation are converging pathways.Critical Issues: In this review, we focus on interventions and their mechanisms that are shown to ameliorate neuropathy in MetS obese models, including: (i) inhibition of a sensory neuron population, (ii), modification of dietary components, (iii) activation of nuclear and mitochondrial lipid pathways, (iv) exercise, and (v) modulation of gut microbiome composition and their metabolites.Future Directions: These past years, novel research increased our knowledge about neuropathy in obesity and discovered the involvement of nonglucose signaling. More studies are necessary to uncover the interplay between complex metabolic pathways in the peripheral nerve system of obese individuals. Further mechanistic studies in preclinical models and humans are crucial to create single- or multitarget interventions for this complex disease implying complex metabolic phenotyping.
C1 [Bonomo, Raiza; Kramer, Sarah; M. Aubert, Virginie] Loyola Univ Chicago, Dept Cell & Mol Physiol, Maywood, IL USA.
   [Kramer, Sarah] Loyola Univ Chicago, Stritch Sch Med, Maywood, IL USA.
   [M. Aubert, Virginie] Loyola Univ Chicago, Dept Cell & Mol Physiol, 1st St, Maywood, IL 60153 USA.
C3 Loyola University Chicago; Loyola University Chicago; Loyola University
   Chicago
RP Aubert, VM (corresponding author), Loyola Univ Chicago, Dept Cell & Mol Physiol, 1st St, Maywood, IL 60153 USA.
EM vmansuyaubert@luc.edu
OI Bonomo Hardy, Raiza/0000-0001-5525-9253; Mansuy-Aubert,
   Virginie/0000-0002-9976-446X
FU DiaComp Pilot & Feasibility project [20AU4112]; NIDDK [5R01DK117404-02];
   National Institute of Diabetes and Digestive and Kidney Diseases
   [R01DK117404] Funding Source: NIH RePORTER
FX The authors are thankful to their funding sources DiaComp Pilot &
   Feasibility project, 20AU4112 and NIDDK 5R01DK117404-02, to V.M.A
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NR 121
TC 16
Z9 16
U1 0
U2 14
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1523-0864
EI 1557-7716
J9 ANTIOXID REDOX SIGN
JI Antioxid. Redox Signal.
PD SEP 1
PY 2022
VL 37
IS 7-9
BP 597
EP 612
DI 10.1089/ars.2021.0278
EA MAY 2022
PG 16
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 6D9DT
UT WOS:000799734500001
PM 35152780
DA 2025-06-11
ER

PT J
AU Fujii, Y
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   Kubota, Y
   Tozawa, K
   Hayashi, Y
   Kohri, K
AF Fujii, Yasuhiro
   Okada, Atsushi
   Yasui, Takahiro
   Niimi, Kazuhiro
   Hamamoto, Shuzo
   Hirose, Masahito
   Kubota, Yasue
   Tozawa, Keiichi
   Hayashi, Yutaro
   Kohri, Kenjiro
TI RETRACTED: Effect of Adiponectin on Kidney Crystal Formation in
   Metabolic Syndrome Model Mice via Inhibition of Inflammation and
   Apoptosis (Retracted Article)
SO PLOS ONE
LA English
DT Article; Retracted Publication
ID ISCHEMIA-REPERFUSION INJURY; INSULIN-RESISTANCE; STONE DISEASE;
   CELL-DEATH; NEPHROLITHIASIS; EXPRESSION; OXALATE; MOUSE; UROLITHIASIS;
   OBESITY
AB The aims of the present study were to elucidate a possible mechanism of kidney crystal formation by using a metabolic syndrome (MetS) mouse model and to assess the effectiveness of adiponectin treatment for the prevention of kidney crystals. Further, we performed genome-wide expression analyses for investigating novel genetic environmental changes. Wild-type (+/+) mice showed no kidney crystal formation, whereas ob/ob mice showed crystal depositions in their renal tubules. However, this deposition was remarkably reduced by adiponectin. Expression analysis of genes associated with MetS-related kidney crystal formation identified 259 genes that were >2.0-fold up-regulated and 243 genes that were <0.5-fold down-regulated. Gene Ontology (GO) analyses revealed that the up-regulated genes belonged to the categories of immunoreaction, inflammation, and adhesion molecules and that the down-regulated genes belonged to the categories of oxidative stress and lipid metabolism. Expression analysis of adiponectin-induced genes related to crystal prevention revealed that the numbers of up- and down-regulated genes were 154 and 190, respectively. GO analyses indicated that the up-regulated genes belonged to the categories of cellular and mitochondrial repair, whereas the down-regulated genes belonged to the categories of immune and inflammatory reactions and apoptosis. The results of this study provide compelling evidence that the mechanism of kidney crystal formation in the MetS environment involves the progression of an inflammation and immunoresponse, including oxidative stress and adhesion reactions in renal tissues. This is the first report to prove the preventive effect of adiponectin treatment for kidney crystal formation by renoprotective activities and inhibition of inflammation and apoptosis.
C1 [Fujii, Yasuhiro; Okada, Atsushi; Yasui, Takahiro; Niimi, Kazuhiro; Hamamoto, Shuzo; Hirose, Masahito; Kubota, Yasue; Tozawa, Keiichi; Hayashi, Yutaro; Kohri, Kenjiro] Nagoya City Univ, Grad Sch Med Sci, Dept Nephrourol, Nagoya, Aichi, Japan.
C3 Nagoya City University
RP Okada, A (corresponding author), Nagoya City Univ, Grad Sch Med Sci, Dept Nephrourol, Nagoya, Aichi, Japan.
EM a-okada@med.nagoya-cu.ac.jp
RI YASUI, Takahiro/E-6401-2018
OI Yasui, Takahiro/0000-0003-2197-2477; Okada, Atsushi/0000-0003-2080-3794
FU Japanese Ministry of Education, Culture, Sports, Science and Technology
   [23249074, 23592374, 23592375, 23791770, 23791774, 23791775, 22591797,
   22791481, 22791479, 22791484, 21791517, 21791520]; Grants-in-Aid for
   Scientific Research [23791775, 24659716, 22791479, 23249074, 21791520,
   23592374, 22791481, 23791774, 25462524, 22591797, 23592375, 23791769,
   22791484, 23791770, 21791517] Funding Source: KAKEN
FX This work was supported in part by Grants-in-Aid for Scientific Research
   (Nos. 23249074, 23592374, 23592375, 23791770, 23791774, 23791775,
   22591797, 22791481, 22791479, 22791484, 21791517, and 21791520) from the
   Japanese Ministry of Education, Culture, Sports, Science and Technology.
   The funders had no role in study design, data collection and analysis,
   decision to publish, or preparation of the manuscript.
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NR 29
TC 36
Z9 36
U1 1
U2 23
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD APR 22
PY 2013
VL 8
IS 4
AR e61343
DI 10.1371/journal.pone.0061343
PG 12
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 130JR
UT WOS:000317911500029
PM 23630583
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Satoh, M
   Ishikawa, Y
   Takahashi, Y
   Itoh, T
   Minami, Y
   Nakamura, M
AF Satoh, Mamoru
   Ishikawa, Yuh
   Takahashi, Yuji
   Itoh, Tomonori
   Minami, Yoshitaka
   Nakamura, Motoyuki
TI Association between oxidative DNA damage and telomere shortening in
   circulating endothelial progenitor cells obtained from metabolic
   syndrome patients with coronary artery disease
SO ATHEROSCLEROSIS
LA English
DT Article
DE acute myocardial infarction; flow cytometry; flow-FISH; stable angina
   pectoris; telomerase
ID STRESS; SUPEROXIDE
AB Metabolic syndrome (MS) induces an increase in oxidative stress and may be an important contributory factor for coronary artery disease (CAD). Telomere shortening of endothelial progenitor cells (EPCs) may be the key factor in endothelial cell senescence. The rate of telomere shortening is highly dependent on cellular oxidative damage. This study analyzed the relationship between telomere shortening and oxidative DNA damage in EPCs obtained from CAD patients with MS and without MS. We analyzed circulating EPCs in peripheral blood obtained from 57 patients with CAD (acute myocardial infarction [AMI], n = 26; stable angina pectoris [AP], n = 31) and 21 age-matched healthy subjects (control). Telomere length and telomerase activity were significantly lower in CAD patients than in controls, and were lower in AMI patients than in AP patients. Oxidative DNA damage was higher in CAD patients compared with controls, and oxidative DNA damage in AMI patients was also higher than in AP patients. There was a negative correlation between telomere length and oxidative DNA damage. Telomere length and telomerase activity were lower in CAD patients with MS than in those without MS. Oxidative DNA damage in CAD patients with MS was higher than in those without MS. In our in vitro study, oxidative treatments induced telomere shortening and decrease in telomerase activity of EPCs. These results suggest that EPC telomere shortening via increased oxidative DNA damage may play an important role in the pathogenesis of CAD. In addition, MS may be related to increased oxidative DNA damage and EPC telomere shortening. (C) 2007 Elsevier Ireland Ltd. All rights reserved.
C1 [Satoh, Mamoru] Iwate Med Univ, Sch Med, Dept Internal Med 2, Morioka, Iwate 0208505, Japan.
   Iwate Med Univ, Sch Med, Mem Heart Ctr, Morioka, Iwate 0208505, Japan.
C3 Iwate Medical University; Iwate Medical University
RP Satoh, M (corresponding author), Iwate Med Univ, Sch Med, Dept Internal Med 2, Uchimaru 19-1, Morioka, Iwate 0208505, Japan.
EM m_satoh@imu.ncvc.go.jp
OI Itoh, Tomonori/0000-0001-9277-6567
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NR 29
TC 123
Z9 139
U1 0
U2 10
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0021-9150
EI 1879-1484
J9 ATHEROSCLEROSIS
JI Atherosclerosis
PD JUN
PY 2008
VL 198
IS 2
BP 347
EP 353
DI 10.1016/j.atherosclerosis.2007.09.040
PG 7
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 319AH
UT WOS:000257133600014
PM 17983621
DA 2025-06-11
ER

PT J
AU Sfarti, CV
   Ciobica, A
   Stanciu, C
   Balan, GG
   Garleanu, I
   Trifan, A
AF Sfarti, Catalin Victor
   Ciobica, Alin
   Stanciu, Carol
   Balan, Gheorghe G.
   Garleanu, Irina
   Trifan, Anca
TI Oxidative Stress Status in Patients with Choledocholithiasis: Before and
   After Endoscopic Sphincterotomy and Biliary Clearance
SO REVISTA DE CHIMIE
LA English
DT Article
DE elderly; endoscopic retrograde cholangiopancreatography; superoxide
   dismutase; gallstones
ID BILE-DUCT LIGATION; LIPID-PEROXIDATION; N-ACETYLCYSTEINE;
   GLUTATHIONE-PEROXIDASE; OBSTRUCTIVE-JAUNDICE; METABOLIC SYNDROME;
   LIVER-DISEASE; RAT-LIVER; ANTIOXIDANT; ENZYME
AB Choledocholithiasis may cause biliary obstruction which leads to hepatocellular injury. Oxidative stress has been proposed as a possible mechanism involved in this disorder. This study evaluates the oxidative stress burden in patients with choledocholithiasis and secondary cholestasis, before and after endoscopic sphincterotomy. Experimental part: Patients diagnosed with choledocholithiasis and secondary extrahepatic cholestasis were included in the study between January 1st 2016 and October 31st 2016. In all patients oxidative stress markers were collected within 2 hours before and 48 hours after therapeutic ERCP. Selected markers were superoxide dismutase (SOD), glutathione peroxidase (GPX) and malondialdehyde (MDA). The results were compared to those from a group of 40 healthy subjects. Significantly lower concentrations of SOD (p = 0.03) and GPX (p < 0.0001) activities, associated with an increased level of MDA level (p < 0.0001) were shown in patients before biliary clearance compared with the healthy control group. After ERCP the only oxidative stress parameter which showed improvement was the SOD specific activity (p = 0.037). This study shows that extrahepatic cholestasis secondary to choledocholithiasis is associated with increased oxidative stress status. After biliary clearance one oxidative stress marker was significantly improved (SOD), suggesting a possible antioxidant effect of such procedure.
C1 [Sfarti, Catalin Victor; Balan, Gheorghe G.; Garleanu, Irina; Trifan, Anca] Grigore T Popa Univ Med & Pharm, 16 Univ Str, Iasi 700115, Romania.
   [Ciobica, Alin] Alexandru Ioan Cuza Univ, Dept Res, Fac Biol, 11 Carol 1 Blvd, Iasi 700506, Romania.
   [Ciobica, Alin; Stanciu, Carol] Romanian Acad, Ctr Biomed Res, 8 Carol 1 Blvd, Iasi 700505, Romania.
   [Ciobica, Alin] Acad Romanian Scientists, 54 Splaiul Independentei, Bucharest 050094, Romania.
C3 Grigore T Popa University of Medicine & Pharmacy; Alexandru Ioan Cuza
   University; Romanian Academy; Academy of Romanian Scientists (AOSR)
RP Ciobica, A (corresponding author), Alexandru Ioan Cuza Univ, Dept Res, Fac Biol, 11 Carol 1 Blvd, Iasi 700506, Romania.; Ciobica, A (corresponding author), Romanian Acad, Ctr Biomed Res, 8 Carol 1 Blvd, Iasi 700505, Romania.; Ciobica, A (corresponding author), Acad Romanian Scientists, 54 Splaiul Independentei, Bucharest 050094, Romania.
EM alin.ciobica@uaic.ro
RI Girleanu, Irina/MTF-8711-2025; Ciobica, Alin/B-6073-2012; Trifan,
   Anca/MTF-7993-2025
OI Trifan, Anca/0000-0001-9144-5520
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NR 64
TC 2
Z9 2
U1 1
U2 4
PU CHIMINFORM DATA S A
PI BUCHAREST
PA CALEA PLEVNEI NR 139, SECTOR 6, BUCHAREST R-77131, ROMANIA
SN 0034-7752
J9 REV CHIM-BUCHAREST
JI Rev. Chim.
PD AUG
PY 2018
VL 69
IS 8
BP 2172
EP 2176
PG 5
WC Chemistry, Multidisciplinary; Engineering, Chemical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Engineering
GA GT6ED
UT WOS:000444602300047
DA 2025-06-11
ER

PT J
AU Sauvé, MF
   Spahis, S
   Delvin, E
   Levy, E
AF Foisy Sauve, Mathilde
   Spahis, Schohraya
   Delvin, Edgard
   Levy, Emile
TI Glycomacropeptide: A Bioactive Milk Derivative to Alleviate Metabolic
   Syndrome Outcomes
SO ANTIOXIDANTS & REDOX SIGNALING
LA English
DT Review
DE glycomacropeptide; casein; oxidative stress; cardiometabolic disorders;
   inflammation; microbiota
ID CHAIN FATTY-ACIDS; KAPPA-CASEIN MACROPEPTIDE; BOVINE GLYCOMACROPEPTIDE;
   ESCHERICHIA-COLI; WHEY-PROTEIN; WEIGHT-LOSS; ALPHA-LACTALBUMIN; INSULIN
   ACTION; AMINO-ACIDS; GOAT MILK
AB Significance:Metabolic syndrome (MetS) represents a cluster of cardiometabolic disorders, which accelerate the risk of developing diabetes, nonalcoholic fatty liver disease, and cardiovascular disorders such as atherosclerosis. Oxidative stress (OxS) and inflammation contribute to insulin resistance (IR) that greatly promotes the clinical manifestations of MetS components. Given the growing prevalence of this multifactorial condition, its alerting comorbidities, and the absence of specific drugs for treatment, there is an urgent need of prospecting for alternative nutraceutics as effective therapeutic agents for MetS. Recent Advances:There is a renewed interest in bioactive peptides derived from human and bovine milk proteins given their high potential in magnifying health benefits. Special attention has been paid to glycomacropeptide (GMP), a bioactive and soluble derivative from casein and milk whey, because of the wide range of its health-promoting functions perceived in the MetS and related complications. Critical Issues:In the present review, the challenging issue relative to clinical utility of GMP in improving MetS outcomes will be critically reported. Its importance in alleviating obesity, OxS, inflammation, IR, dyslipidemia, and hypertension will be underlined. The mechanisms of action will be analyzed, and the various gaps of knowledge in this area will be specified. Future Directions:Valuable data from cellular, preclinical, and clinical investigations have emphasized the preventive and therapeutic actions of GMP toward the MetS. However, additional efforts are needed to support its proofs of principle and causative relationship to translate its concept into the clinic.
C1 [Foisy Sauve, Mathilde; Spahis, Schohraya; Delvin, Edgard; Levy, Emile] CHU St Justine, Res Ctr, 3175 Cote Ste Catherine, Montreal, PQ H3T 1C5, Canada.
   [Foisy Sauve, Mathilde; Spahis, Schohraya; Levy, Emile] Univ Montreal, Dept Nutr, Montreal, PQ, Canada.
C3 Universite de Montreal; Centre Hospitalier Universitaire Sainte-Justine;
   Universite de Montreal
RP Levy, E (corresponding author), CHU St Justine, Res Ctr, 3175 Cote Ste Catherine, Montreal, PQ H3T 1C5, Canada.
EM emile.levy@recherche-ste-justine.qc.ca
OI Spahis, Schohraya/0000-0003-4130-4994
FU CIHR Funding Source: Medline
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NR 157
TC 16
Z9 19
U1 5
U2 61
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1523-0864
EI 1557-7716
J9 ANTIOXID REDOX SIGN
JI Antioxid. Redox Signal.
PD JAN 20
PY 2021
VL 34
IS 3
BP 201
EP 222
DI 10.1089/ars.2019.7994
PG 22
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA PP0DR
UT WOS:000605540800003
PM 32338040
DA 2025-06-11
ER

PT J
AU Illesca, PG
   Alvarez, SM
   Selenscig, DA
   Ferreira, MD
   Giménez, MS
   Lombardo, YB
   D'Alessandro, ME
AF Illesca, Paola G.
   Alvarez, Silvina M.
   Selenscig, Dante A.
   Ferreira, Maria del R.
   Gimenez, Maria S.
   Lombardo, Yolanda B.
   D'Alessandro, Maria E.
TI Dietary soy protein improves adipose tissue dysfunction by modulating
   parameters related with oxidative stress in dyslipidemic
   insulin-resistant rats
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Article
DE Soy protein; High sucrose diet; Adipose tissue; Antioxidant defenses;
   Oxidative stress; Visceral adiposity
ID METABOLIC ABNORMALITIES; LIPID-METABOLISM; SKELETAL-MUSCLE; OBESITY;
   GENISTEIN; LIVER; INFLAMMATION; MECHANISMS; ISOFLAVONES; SECRETION
AB The present study investigates the benefits of the dietary intake of soy protein on adipose tissue dysfunction in a rat model that mimics several aspects of the human metabolic syndrome. Wistar rats were fed a sucrose-rich diet (SRD) for 4 months. After that, half of the animals continued with SRD until month 8 while in the other half, casein protein was replaced by isolated soy protein for 4 months (SRD-S). A reference group consumed a control diet all the time. In adipose tissue we determined: i) the activities of antioxidant enzymes, gene expression of Mn-superoxide dismutase (SOD) and glutathione peroxidase (GPx), and glutathione redox state ii) the activity of xanthine oxidase (XO), ROS levels and the gene expression of NAD(P) H oxidase iii) the expression of the nuclear factor erythroid-2 related factor-2 (Nrf2). Besides, adiposity visceral index, insulin sensitivity, and tumor necrosis factor-alpha (TNF-alpha ) in plasma were determined. Compared with the SRD-fed rats, the animals fed a SRD-S showed: activity normalization of SOD and glutathione reductase, improvement of mRNA SOD and normalization of mRNA GPx without changes in the expression of the Nrf2, and improvement of glutathione redox state. These results were accompanied by a normalization of XO activity and improvement of both the ROS production as well as TNF-alpha levels in plasma. Besides, adipocyte size distribution, adiposity visceral index and insulin sensitivity improved. The results suggest that soy protein can be a complementary nutrient for treating some signs of the metabolic syndrome. (C) 2017 Elsevier Masson SAS. All rights reserved.
C1 [Illesca, Paola G.; Selenscig, Dante A.; Ferreira, Maria del R.; Lombardo, Yolanda B.; D'Alessandro, Maria E.] Univ Litoral, Sch Biochem, Dept Biochem, Ciudad Univ,El Pozo CC 242, RA-3000 Santa Fe, Argentina.
   [Alvarez, Silvina M.; Gimenez, Maria S.] Natl Univ San Luis, Lab Mol Biochem, Fac Chem Biochem & Pharm, Ave Ejercito Andes 950, RA-5700 San Luis, Argentina.
   [Alvarez, Silvina M.; Ferreira, Maria del R.; Gimenez, Maria S.; Lombardo, Yolanda B.; D'Alessandro, Maria E.] Consejo Nacl Invest Cient & Tecn, Consejo Nacl Invest Cient & Tecn, RA-1033 Buenos Aires, DF, Argentina.
C3 National University of the Littoral; Universidad Nacional de San Luis;
   Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET)
RP D'Alessandro, ME (corresponding author), Univ Litoral, Sch Biochem, Dept Biochem, Ciudad Univ,El Pozo CC 242, RA-3000 Santa Fe, Argentina.
EM medaless@fbcb.unl.edu.ar
RI Alvarez, Silvina/GOE-5780-2022; Illesca, Paola/IVH-6615-2023
OI Illesca, Paola/0000-0002-8491-2458; Ferreira, Maria del
   Rosario/0000-0003-0760-9495; Gimenez, Maria Sofia/0000-0003-1312-0661;
   Alvarez, Silvina/0000-0001-7522-7208; D' Alessandro, Maria
   Eugenia/0000-0001-6008-5614
FU University of Litoral [50120110100293-2012]; Agencia Nacional de
   Promocion Cientifica y Tecnologica (ANPCyT) [PICT 945 BID OC/AR 2011];
   CONICET [0105]
FX The present study was supported by the University of Litoral [grant
   CAI+D number 50120110100293-2012]; the Agencia Nacional de Promocion
   Cientifica y Tecnologica (ANPCyT) [grant number PICT 945 BID OC/AR
   2011]; and the CONICET [grant PIP number 0105].
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NR 50
TC 10
Z9 10
U1 0
U2 11
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD APR
PY 2017
VL 88
BP 1008
EP 1015
DI 10.1016/j.biopha.2017.01.153
PG 8
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA EM7YJ
UT WOS:000395528000120
PM 28178612
OA Green Published
DA 2025-06-11
ER

PT J
AU Hardeland, R
AF Hardeland, Ruediger
TI Melatonin and the pathologies of weakened or dysregulated circadian
   oscillators
SO JOURNAL OF PINEAL RESEARCH
LA English
DT Review
DE aging; cancer; circadian; melatonin; sirtuin 1; type 2 diabetes
ID INFORMATION REGULATOR 1; ENDOPLASMIC-RETICULUM STRESS; MESENCHYMAL
   STEM-CELLS; INSULIN-RESISTANCE; METABOLIC SYNDROME; OXIDATIVE STRESS;
   IN-VITRO; GENE-EXPRESSION; MITOCHONDRIAL DYSFUNCTION;
   MOLECULAR-MECHANISMS
AB Dynamic aspects of melatonin's actions merit increasing future attention. This concerns particularly entirely different effects in senescent, weakened oscillators and in dysregulated oscillators of cancer cells that may be epigenetically blocked. This is especially obvious in the case of sirtuin 1, which is upregulated by melatonin in aged tissues, but strongly downregulated in several cancer cells. These findings are not at all controversial, but are explained on the basis of divergent changes in weakened and dysregulated oscillators. Similar findings can be expected to occur in other accessory oscillator components that are modulated by melatonin, among them several transcription factors and metabolic sensors. Another cause of opposite effects concerns differences between nocturnally active laboratory rodents and the diurnally active human. This should be more thoroughly considered in the field of metabolic syndrome and related pathologies, especially with regard to type 2 diabetes and other aspects of insulin resistance. Melatonin was reported to impair glucose tolerance in humans, especially in carriers of the risk allele of the MT2 receptor gene, MTNR1B, that contains the SNP rs10830963. These findings contrast with numerous reports on improvements of glucose tolerance in preclinical studies. However, the relationship between melatonin and insulin may be more complex, as indicated by loss-of-function mutants of the MT2 receptor that are also prodiabetic, by the age-dependent time course of risk allele overexpression, by progressive reduction in circadian amplitudes and melatonin secretion, which are aggravated in diabetes. By supporting high-amplitude rhythms, melatonin may be beneficial in preventing or delaying diabetes.
C1 [Hardeland, Ruediger] Univ Gottingen, Johann Friedrich Blumenbach Inst Zool & Anthropol, Gottingen, Germany.
C3 University of Gottingen
RP Hardeland, R (corresponding author), Univ Gottingen, Johann Friedrich Blumenbach Inst Zool & Anthropol, Gottingen, Germany.
EM rhardel@gwdg.de
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NR 216
TC 83
Z9 87
U1 0
U2 18
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0742-3098
EI 1600-079X
J9 J PINEAL RES
JI J. Pineal Res.
PD JAN
PY 2017
VL 62
IS 1
AR e12377
DI 10.1111/jpi.12377
PG 16
WC Endocrinology & Metabolism; Neurosciences; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Physiology
GA EM0RU
UT WOS:000395026200002
PM 27763686
OA Bronze
DA 2025-06-11
ER

PT J
AU Baez-Duarte, BG
   Zamora-Ginez, I
   De Jésus, KL
   Torres-Rasgado, E
   González-Mejía, E
   Porchia, L
   Ruiz-Vivanco, G
   Pérez-Fuentes, R
AF Baez-Duarte, Blanca G.
   Zamora-Ginez, Irma
   Luna De Jesus, Karina
   Torres-Rasgado, Enrique
   Gonzalez-Mejia, Elba
   Porchia, Leonardo
   Ruiz-Vivanco, Guadalupe
   Perez-Fuentes, Ricardo
TI Association of the Metabolic Syndrome with Antioxidant Defense and
   Outstanding Superoxide Dismutase Activity in Mexican Subjects
SO METABOLIC SYNDROME AND RELATED DISORDERS
LA English
DT Article
ID GAMMA-GLUTAMYLCYSTEINE SYNTHETASE; GLUTATHIONE-PEROXIDASE ACTIVITIES;
   SYSTEMIC OXIDATIVE STRESS; FAT OVERLOAD; CATALASE; INSULIN;
   DYSREGULATION; EXPRESSION; BIOMARKERS; OXIDASE
AB Background: Metabolic syndrome (MetS) is considered a public health problem worldwide. Recently, oxidative stress (OS) has been proposed as a factor related with the genesis of MetS. Different studies have reported decreased antioxidant defense, such as superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase (GRed) activities, and reduced glutathione (GSH) concentration, and, on the other hand, an increase in nitrotyrosine concentration in MetS patients. However, it is not known whether there is a direct association of antioxidant defense with MetS in a Mexican population.
   The aim of the study was to determine the relationship between antioxidant defense and MetS in Mexican subjects.
   Materials and Methods: The subjects were Mexican mestizos, who were anthropometrically, biochemically, and clinically characterized. MetS was diagnosed by National Cholesterol Education Program-Adult Treatment Panel III (NCEP-ATP III)-modified criteria. Antioxidant defense was determined by activity of SOD, GPx, GRed, and GSH concentrations; as a marker of OS, nitrotyrosine concentration was determined.
   Results: The study included 376 subjects, among whom 152 subjects had MetS and 224 were assigned to the non-MetS group. Statistical association was found between MetS and SOD activity (Odds ratio: 167.1; P < 0.01; adjusted by age, gender, and waist circumference). It is noteworthy that a significant correlation between antioxidant defense (SOD and GPx activities, and GSH) and different MetS components was found and between MetS and nitrotyrosine concentration (P < 0.05).
   Conclusion: The results indicate that SOD activity is associated with MetS in Mexican subjects, allowing us to suggest that this enzyme plays an important role in the pathophysiology of MetS.
C1 [Baez-Duarte, Blanca G.; Zamora-Ginez, Irma; Torres-Rasgado, Enrique; Gonzalez-Mejia, Elba; Ruiz-Vivanco, Guadalupe; Perez-Fuentes, Ricardo] Benemerita Univ Autonoma Puebla, Fac Med, Ave 13 Sur 2702, Puebla 72410, Mexico.
   [Luna De Jesus, Karina] Benemerita Univ Autonoma Puebla, Fac Ciencias Quim, Ciudad Univ, Puebla 72410, Mexico.
   [Porchia, Leonardo; Perez-Fuentes, Ricardo] Inst Mexicano Seguro Social, Ctr Invest Biomed Oriente CIBIOR, Puebla, Mexico.
C3 Benemerita Universidad Autonoma de Puebla; Benemerita Universidad
   Autonoma de Puebla; Instituto Mexicano del Seguro Social
RP Baez-Duarte, BG (corresponding author), Benemerita Univ Autonoma Puebla, Fac Med, Ave 13 Sur 2702, Puebla 72410, Mexico.
EM blanquis121280@yahoo.com.mx
RI Gonzalez-Mejia, M./F-8739-2012; Zamora-Ginez, Irma/AEI-8729-2022
OI Baez Duarte, Blanca Guadalupe/0000-0002-2311-8605; Gonzalez-Mejia, M.
   Elba/0000-0003-2569-1998; Porchia, Leonardo Martin/0000-0002-4082-7606;
   Luna de Jesus, Karina/0009-0004-9706-1981; Ruiz Vivanco,
   Guadalupe/0000-0001-5685-3860; Zamora-Ginez, Irma/0000-0003-0403-2969
FU Programa de Mejoramiento del Profesorado (PROMEP) such as NPTC [PTC-342,
   PROMEP/103.5/13/6823]
FX This study was conducted at the Eastern Biomedical Research Center of
   the Instituto Mexicano del Seguro Social (CIBIOR, IMSS) in Puebla,
   Mexico. The authors gratefully acknowledge the commitment and dedication
   of physicians, chemists, nurses, nutritionists, and participating
   personnel in the study. This study was supported by grants from the
   Programa de Mejoramiento del Profesorado (PROMEP) such as NPTC with
   folio number PTC-342, agreement number PROMEP/103.5/13/6823.
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NR 46
TC 14
Z9 15
U1 1
U2 10
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-4196
EI 1557-8518
J9 METAB SYNDR RELAT D
JI Metab. Syndr. Relat. Disord.
PD APR 1
PY 2016
VL 14
IS 3
BP 154
EP 160
DI 10.1089/met.2015.0088
PG 7
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA DH0EP
UT WOS:000372455600004
PM 26859464
DA 2025-06-11
ER

PT J
AU Ciciliot, S
   Albiero, M
   Menegazzo, L
   Poncina, N
   Scattolini, V
   Danesi, A
   Pagnin, E
   Marabita, M
   Blaauw, B
   Giorgio, M
   Trinei, M
   Foletto, M
   Prevedello, L
   Nitti, D
   Avogaro, A
   Fadini, GP
AF Ciciliot, Stefano
   Albiero, Mattia
   Menegazzo, Lisa
   Poncina, Nicol
   Scattolini, Valentina
   Danesi, Andrea
   Pagnin, Elisa
   Marabita, Manuela
   Blaauw, Bert
   Giorgio, Marco
   Trinei, Mirella
   Foletto, Mirto
   Prevedello, Luca
   Nitti, Donato
   Avogaro, Angelo
   Fadini, Gian Paolo
TI p66Shc deletion or deficiency protects from obesity but not
   metabolic dysfunction in mice and humans
SO DIABETOLOGIA
LA English
DT Article
DE Diabesity; Inflammation; Longevity; Oxidative stress
ID OXIDATIVE STRESS; ADIPOSE-TISSUE; INSULIN-RESISTANCE; FAT ACCUMULATION;
   ADAPTER PROTEIN; P66(SHC) GENE; LIFE-SPAN; APOPTOSIS; MAMMALS; CELLS
AB Aims/hypothesis Oxygen radicals generated by p66Shc drive adipogenesis, but contradictory data exist on the role of p66Shc in the development of obesity and the metabolic syndrome. We herein explored the relationships among p66Shc, adipose tissue remodelling and glucose metabolism using mouse models and human adipose tissue samples.
   Methods In wild-type (WT), leptin-deficient (ob/ob), p66Shc(-/-) and p66Shc(-/-) ob/ob mice up to 30 weeks of age, we analysed body weight, subcutaneous and visceral adipose tissue histopathology, glucose tolerance and insulin sensitivity, and liver and muscle fat accumulation. A group of mice on a high fat diet (HFD) was also analysed. A parallel study was conducted on adipose tissue collected from patients undergoing elective surgery.
   Results We found that p66Shc(-/-) mice were slightly leaner than WT mice, and p66Shc(-/-) ob/ob mice became less obese than ob/ob mice. Despite their lower body weight, p66Shc(-/-) mice accumulated ectopic fat in the liver and muscles, and were glucose intolerant and insulin resistant. Features of adverse adipose tissue remodelling induced by obesity, including adipocyte enlargement, apoptosis, inflammation and perfusion were modestly and transiently improved by p66Shc (also known as Shc1) deletion. After 12 weeks of the HFD, p66Shc(-/-) mice were leaner than but equally glucose intolerant and insulin resistant compared with WT mice. In 77 patients, we found a direct correlation between BMI and p66Shc protein levels. Patients with low p66Shc levels were less obese, but were not protected from other metabolic syndrome features (diabetes, dyslipidaemia and hypertension).
   Conclusions/interpretation In mice and humans, reduced p66Shc levels protect from obesity, but not from ectopic fat accumulation, glucose intolerance and insulin resistance.
C1 [Ciciliot, Stefano; Albiero, Mattia; Menegazzo, Lisa; Poncina, Nicol; Scattolini, Valentina; Pagnin, Elisa; Avogaro, Angelo; Fadini, Gian Paolo] Univ Padua, Dept Med, I-35128 Padua, Italy.
   [Ciciliot, Stefano; Albiero, Mattia; Menegazzo, Lisa; Poncina, Nicol; Scattolini, Valentina; Danesi, Andrea; Marabita, Manuela; Blaauw, Bert; Avogaro, Angelo; Fadini, Gian Paolo] Venetian Inst Mol Med, Padua, Italy.
   [Blaauw, Bert] Univ Padua, Dept Biomed Sci, I-35128 Padua, Italy.
   [Giorgio, Marco; Trinei, Mirella] European Inst Oncol, Milan, Italy.
   [Foletto, Mirto; Prevedello, Luca; Nitti, Donato] Univ Padua, Dept Surg, Oncol Gastroenterol Sci, I-35128 Padua, Italy.
C3 University of Padua; Veneto Institute Molecular Medicine; University of
   Padua; IRCCS European Institute of Oncology (IEO); University of Padua
RP Fadini, GP (corresponding author), Univ Padua, Dept Med, Via Giustiniani 2, I-35128 Padua, Italy.
EM Gianpaolo.fadini@unipd.it
RI Giorgio, Marco/I-9425-2012; Avogaro, Angelo/S-3808-2016; Fadini,
   Gian/M-4575-2019; foletto, mirto/I-5182-2018; Albiero,
   Mattia/AAG-4257-2019; blaauw, bert/A-7614-2014; Ciciliot,
   Stefano/L-3887-2019
OI AVOGARO, ANGELO/0000-0002-1177-0516; Ciciliot,
   Stefano/0000-0002-5833-6581; Scattolini, Valentina/0000-0002-0855-9402;
   BLAAUW, BERT/0000-0002-4167-5106; FADINI, GIAN
   PAOLO/0000-0002-6510-2097; Albiero, Mattia/0000-0003-4142-9738
FU Italian Ministry of Health [GR-2010-2301676]
FX This study was funded by an Italian Ministry of Health grant (no.
   GR-2010-2301676) to GPF.
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NR 22
TC 27
Z9 29
U1 0
U2 14
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0012-186X
EI 1432-0428
J9 DIABETOLOGIA
JI Diabetologia
PD OCT
PY 2015
VL 58
IS 10
BP 2352
EP 2360
DI 10.1007/s00125-015-3667-8
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA CR7NY
UT WOS:000361538600019
PM 26122877
OA Bronze
DA 2025-06-11
ER

PT J
AU Nestorov, J
   Glban, AM
   Mijuskovic, A
   Nikolic-Kokic, A
   Elakovic, I
   Velickovic, N
   Matic, G
AF Nestorov, Jelena
   Glban, Alhadi M.
   Mijuskovic, Ana
   Nikolic-Kokic, Aleksandra
   Elakovic, Ivana
   Velickovic, Natasa
   Matic, Gordana
TI Long-term fructose-enriched diet introduced immediately after weaning
   does not induce oxidative stress in the rat liver
SO NUTRITION RESEARCH
LA English
DT Article
DE Antioxidant enzymes; Fructose-fed rat; Liver; Oxidative stress; Young
   rats
ID MANGANESE-SUPEROXIDE-DISMUTASE; METABOLIC SYNDROME; SWEETENED BEVERAGES;
   INACTIVATION; PEROXYNITRITE; CATALASE; DISEASE; OBESITY; INJURY; TISSUE
AB Increased fructose consumption is correlated with the rising prevalence of obesity, metabolic syndrome, and type 2 diabetes. It is believed that reactive oxygen species contribute to the development and progression of metabolic disturbances, especially those associated with insulin resistance. Dietary fructose produces both pro-oxidative and antioxidative effects, depending upon the experimental conditions, dosage, duration of treatment, and pathophysiological milieu. The effects of fructose overconsumption on young populations, which have an increased risk of developing metabolic disorders in adulthood, have not been fully elucidated. We have previously shown that rats subjected to a long-term fructose-enriched diet immediately after weaning display impaired hepatic insulin sensitivity. In this study, we tested the hypothesis that long-term fructose consumption induces alterations in the redox setting of the liver. Starting from the 21st day afterbirth, male Wistar rats were maintained for 9 weeks on a standard diet (control) or a fructose-enriched diet that consisted of standard food and 10% fructose solution instead of drinking water. The expression and activity of antioxidant enzymes as well as lipid peroxidation and protein damage markers were measured. The results showed that a fructose-enriched diet led to an increased expression of mitochondrial manganese superoxide dismutase but did not affect antioxidant enzymes activity, lipid peroxidation, thiol content, and the level of protein oxidation. Therefore, our results suggest that the decrease in hepatic insulin sensitivity that was previously observed in rats that were kept on the same diet regime might be attributed to molecular mechanisms other than redox disbalance. A possible fructose-related micronutrient deficiency should be examined. (C) 2014 Elsevier Inc. All rights reserved.
C1 [Nestorov, Jelena; Glban, Alhadi M.; Elakovic, Ivana; Velickovic, Natasa; Matic, Gordana] Univ Belgrade, Inst Biol Res Sinisa Stankovic, Dept Biochem, Belgrade 11060, Serbia.
   [Mijuskovic, Ana; Nikolic-Kokic, Aleksandra] Univ Belgrade, Inst Biol Res Sinisa Stankovic, Dept Physiol, Belgrade 11060, Serbia.
C3 University of Belgrade; University of Belgrade
RP Nestorov, J (corresponding author), Univ Belgrade, Inst Biol Res Sinisa Stankovic, Dept Biochem, Belgrade 11060, Serbia.
EM brkljacic@ibiss.bg.ac.rs
RI Brkljacic, Jelena/JQW-4422-2023; Matic, Gordana/N-7134-2014;
   Nikolic-Kokic, Aleksandra/AAD-5591-2022
OI Brkljacic, Jelena/0000-0003-1978-8646; Matic,
   Gordana/0000-0002-0142-1056; Velickovic, Natasa/0000-0003-3604-5836;
   Nikolic-Kokic, Aleksandra/0000-0002-1116-2035
FU Ministry of Education, Science and Technological Development of the
   Republic of Serbia [III41009]
FX This work was supported by the Ministry of Education, Science and
   Technological Development of the Republic of Serbia, Grant III41009.
   There are no conflicts of interest regarding the publication of this
   article.
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NR 44
TC 9
Z9 10
U1 0
U2 6
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0271-5317
J9 NUTR RES
JI Nutr. Res.
PD JUL
PY 2014
VL 34
IS 7
BP 646
EP 652
DI 10.1016/j.nutres.2014.06.006
PG 7
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA AO2CW
UT WOS:000341124100011
PM 25150124
DA 2025-06-11
ER

PT J
AU Milic, M
   Kisan, M
   Rogulj, D
   Radman, M
   Lovrencic, MV
   Konjevoda, P
   Domijan, AM
AF Milic, Mirta
   Kisan, Maja
   Rogulj, Dinko
   Radman, Maja
   Lovrencic, Marijana Vucic
   Konjevoda, Pasko
   Domijan, Ana-Marija
TI Level of primary DNA damage in the early stage of metabolic syndrome
SO MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
LA English
DT Article
DE Alkaline comet assay; hOGG1-modified comet assay; Neutral comet assay;
   Urinary 8-oxo-dG; Oxidative stress
ID COMET ASSAY; OXIDATIVE STRESS; REPAIR; CELLS; ASSOCIATION
AB Metabolic syndrome (MetS) is a multi-component disease, characterised by abdominal obesity, hypertension, hyperglycaemia and dyslipidaemia. Since the number of MetS patients has significantly increased over the past two decades and because MetS may lead to development of cardiovascular diseases, diabetes type-2, and cancer, it has become important to extend the knowledge on the pathogenesis of MetS and to establish its possible early biomarkers. Studies on MetS and DNA damage are few and are inconclusive. The aim of this study was to elucidate the involvement of DNA damage in the development of MetS and to establish if DNA damage can serve as early biomarker of MetS. A total of 121 subjects participated in the study: 56 healthy controls and 65 MetS patients who were diagnosed with MetS for the first time. The amount of primary DNA damage in peripheral leukocytes of the subjects was assessed with three types of comet assay: the alkaline, the hOGG1-modified, and the neutral comet assay. In addition, the extent of oxidative DNA damage was monitored in urine by assessing 8-oxo-dG. The parameters of the three types of comet assay did not differ between the control and the MetS group. Interestingly, urinary 8-oxo-dG level in the control group was higher than in the MetS group. Our results imply that DNA damage is not involved in the early stage of MetS and, therefore, DNA damage cannot serve as an early marker of MetS, (C) 2013 Elsevier B.V. All rights reserved,
C1 [Milic, Mirta] Inst Med Res & Occupat Hlth, Mutagenesis Unit, Zagreb 41000, Croatia.
   [Kisan, Maja; Domijan, Ana-Marija] Univ Zagreb, Fac Pharm & Biochem, Zagreb 41000, Croatia.
   [Rogulj, Dinko] Polyclin Sunce, Zagreb, Croatia.
   [Radman, Maja] Univ Hosp Ctr Split, Dept Internal Med, Split, Croatia.
   [Lovrencic, Marijana Vucic] Clin Hosp Merkur, Dept Clin Chem, Zagreb, Croatia.
   [Lovrencic, Marijana Vucic] Clin Hosp Merkur, Lab Med, Zagreb, Croatia.
   [Konjevoda, Pasko] Rudjer Boskovic Inst, NMR Ctr, Zagreb, Croatia.
C3 Institute for Medical Research & Occupational Health (IMROH); University
   of Zagreb; University of Split; Rudjer Boskovic Institute
RP Domijan, AM (corresponding author), Univ Zagreb, Fac Pharm & Biochem, Zagreb 41000, Croatia.
EM adomijan@pharma.hr
RI Radman, Maja/H-2891-2017; Milic, Mirta/T-4887-2018
OI Konjevoda, Pasko/0000-0003-3966-1132; Vucic Lovrencic,
   Marijana/0000-0001-7365-0627; Milic, Mirta/0000-0002-9837-7185
FU the Ministry of Science, Education, and Sports of the Republic of
   Croatia [0022-0222148-2137]
FX This study was supported by the Ministry of Science, Education, and
   Sports of the Republic of Croatia (Grant Number 0022-0222148-2137).
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NR 35
TC 17
Z9 18
U1 0
U2 16
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1383-5718
EI 1879-3592
J9 MUTAT RES-GEN TOX EN
JI Mutat. Res. Genet. Toxicol. Environ. Mutagen.
PD DEC 12
PY 2013
VL 758
IS 1-2
BP 1
EP 5
DI 10.1016/j.mrgentox.2013.07.013
PG 5
WC Biotechnology & Applied Microbiology; Genetics & Heredity; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Genetics & Heredity; Toxicology
GA 276CB
UT WOS:000328724600001
PM 24076402
DA 2025-06-11
ER

PT J
AU Meineri, G
   Ingravalle, F
   Radice, E
   Aragno, M
   Peiretti, PG
AF Meineri, G.
   Ingravalle, F.
   Radice, E.
   Aragno, M.
   Peiretti, P. G.
TI Effects of High Fat Diets and Spirulina platensis Supplementation
   in New Zealand White Rabbits
SO JOURNAL OF ANIMAL AND VETERINARY ADVANCES
LA English
DT Article
DE Obesity; Spirulina platensis; metabolic syndrome; rabbits; fats; plasma
ID INSULIN-RESISTANCE; OXIDATIVE STRESS; LIPOPROTEIN-LIPASE; TRANSGENIC
   RABBITS; CENTRAL OBESITY; DISEASE; ALPHA; HEART; MODEL; COMPLICATIONS
AB The present study was designed to examine, whether rabbits fed a diet containing High Fat (HF) could develop obesity and be predisposed to developing metabolic syndrome (Mets). The results have shown an increased adipose accumulation with a significant weight gain and an increase in abdominal circumference, periscapolar fat and liver weight in rabbits fed HF diets compared to rabbits fed a Low Fat (LFC) diet, associated with higher levels of plasma glucose, insulin and lower levels of High-Density-Lipoprotein (HDL) cholesterol in the rabbits fed the HF diets than the rabbits fed the LFC diet. An Oral Glucose Tolerance Test (OGTT) has been performed to evaluate glucose metabolism; the plasma glucose levels in the rabbits fed the HF diets were constantly higher (statistically significant at 0, 60, 90, 120 and 240 min) than in the rabbits fed the LFC diet. The association between the HF diets and oxidative stress, indicated by the presence of Reactive Oxygen Species (ROS) in plasma, has also been investigated; the rabbits fed the HF diets had higher ROS values than the rabbits fed the LFC diet. In addition, the protective effect of Spirulina platensis (SP), antioxidant of vegetable origin, has also been investigated. The SP supplementation (10 g kg(-1) of the diet) did not have any effect on the morphological data or some parameters in plasma, while SP was able to reduce the ROS value in rabbits fed the high fat diet probably due to beneficial effect of the gamma-linolenic acid content in the SP.
C1 [Meineri, G.] Univ Torino, Dept Anim Prod Epidemiol & Ecol, I-10095 Grugliasco, Italy.
   [Peiretti, P. G.] CNR, Inst Sci & Food Prod, Grugliasco, Italy.
   [Aragno, M.] Univ Turin, Dept Expt Med & Oncol, Gen Pathol Sect, Turin, Italy.
   [Radice, E.] Univ Torino, Dept Clin Physiopathol, Turin, Italy.
   [Ingravalle, F.] Ist Zooprofilatt Sperimentale Piemonte Liguria &, Turin, Italy.
C3 University of Turin; Consiglio Nazionale delle Ricerche (CNR); Istituto
   Scienze delle Produzioni Alimentari (ISPA-CNR); University of Turin;
   University of Turin; IZS Piemonte Liguria e Valle D'aosta
RP Meineri, G (corresponding author), Univ Torino, Dept Anim Prod Epidemiol & Ecol, Via L Da Vinci 44, I-10095 Grugliasco, Italy.
RI Peiretti, Pier/B-6871-2013
OI Radice, Elisabetta/0000-0003-1935-7512; MEINERI,
   Giorgia/0000-0002-4969-5136; Ingravalle, Francesco/0000-0003-0722-7120;
   Peiretti, Pier Giorgio/0000-0001-7072-3974; ARAGNO,
   Manuela/0000-0002-0453-5235
FU University funds
FX The research was supported by University funds. Thanks are due to Dr. I.
   Vercellinatto for her technical support.
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NR 56
TC 13
Z9 14
U1 1
U2 5
PU MEDWELL ONLINE
PI FAISALABAD
PA ANSINET BUILDING, 308-LASANI TOWN, SARGODHA RD, FAISALABAD, 38090,
   PAKISTAN
SN 1680-5593
EI 1993-601X
J9 J ANIM VET ADV
JI J. Anim. Vet. Adv.
PD DEC
PY 2009
VL 8
IS 12
BP 2735
EP 2744
PG 10
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA 517NZ
UT WOS:000271623400058
DA 2025-06-11
ER

PT J
AU Bouzas, C
   Bibiloni, MD
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   Martinez-Gonzalez, MA
   Salas-Salvado, J
   Corella, D
   Goday, A
   Martinez, JA
   Alonso-Gomez, AM
   Waernberg, J
   Vioque, J
   Romaguera, D
   Lopez-Miranda, J
   Estruch, R
   Tinahones, FJ
   Lapetra, J
   Serra-Majem, L
   Riquelme-Gallego, B
   Martin-Sanchez, V
   Pinto, X
   Gaforio, JJ
   Matia, P
   Vidal, J
   Vazquez, C
   Daimiel, L
   Ros, E
   Pascual-Roquet-Jalmar, E
   Babio, N
   Gonzalez-Monge, I
   Castaner, O
   Abete, I
   Sorto-Sanchez, C
   Benavente-Marin, JC
   Torres-Collado, L
   Martin, M
   Garcia-Rios, A
   Castro-Barquero, S
   Fernandez-Garcia, JC
   Santos-Lozano, JM
   Fernandez-Lazaro, CI
   Salas-Huetos, A
   Guillem-Saiz, P
   Zomeno, MD
   Zulet, MA
   Goikoetxea-Bahon, A
   Gea, A
   Nishi, SK
   Schroeder, H
   Tur, JA
AF Bouzas, Cristina
   Bibiloni, Maria del Mar
   Garcia, Silvia
   Mateos, David
   Martinez-Gonzalez, Miguel Angel
   Salas-Salvado, Jordi
   Corella, Dolores
   Goday, Albert
   Martinez, J. Alfredo
   Alonso-Gomez, Angel M.
   Waernberg, Julia
   Vioque, Jesus
   Romaguera, Dora
   Lopez-Miranda, Jose
   Estruch, Ramon
   Tinahones, Francisco J.
   Lapetra, Jose
   Serra-Majem, Lluis
   Riquelme-Gallego, Blanca
   Martin-Sanchez, Vicente
   Pinto, Xavier
   Gaforio, Jose J.
   Matia, Pilar
   Vidal, Josep
   Vazquez, Clotilde
   Daimiel, Lidia
   Ros, Emilio
   Pascual-Roquet-Jalmar, Elena
   Babio, Nancy
   Gonzalez-Monge, Inmaculada
   Castaner, Olga
   Abete, Itziar
   Sorto-Sanchez, Carolina
   Carlos Benavente-Marin, Juan
   Torres-Collado, Laura
   Martin, Marian
   Garcia-Rios, Antonio
   Castro-Barquero, Sara
   Fernandez-Garcia, Jose C.
   Santos-Lozano, Jose Manuel
   Fernandez-Lazaro, Cesar I.
   Salas-Huetos, Albert
   Guillem-Saiz, Patricia
   Zomeno, Maria Dolores
   angeles Zulet, Maria
   Goikoetxea-Bahon, Amaia
   Gea, Alfredo
   Nishi, Stephanie K.
   Schroeder, Helmut
   Tur, Josep A.
CA PREDIMED-Plus Investigators
TI Desired weight loss and its association with health, health behaviors
   and perceptions in an adult population with weight excess: One-year
   follow-up
SO FRONTIERS IN NUTRITION
LA English
DT Article
DE desired weight loss; Mediterranean diet; health perception;
   PREDIMED-plus trial; metabolic syndrome
ID SPANISH VERSION; BODY-WEIGHT; QUESTIONNAIRE; SATISFACTION; MAINTENANCE;
   DEPRESSION; STRATEGIES; STIGMA; IMAGE; SIZE
AB Background: Metabolic syndrome (MetS) worsens quality of life and increases mortality. Dissatisfaction with weight in patients with MetS may modify the effect of lifestyle interventions to achieve changes in health-related behaviors. Objective: To assess 1-year changes in cardiovascular risk scores, self-perceived general health and health-related behaviors according to observed changes in desired weight loss during the first year of intervention in a large cardiovascular prevention trial. Design: Prospective analysis of the PREDIMED-PLUS trial, including 5,499 adults (55-75 years old) with overweight or obesity at baseline. Methods: The desired weight loss was the difference between ideal and measured weight. Tertiles of change in desired weight loss (1 year vs. baseline) were defined by the following cut-off points: >= 0.0 kg (T1, n = 1,638); 0.0 to -4.0 kg (T2, n = 1,903); <=-4.0 kg (T3, n = 1,958). A food frequency questionnaire assessed diet and the Minnesota-REGICOR questionnaire assessed physical activity. The Framingham equation assessed cardiovascular risks. The changes in the severity of MetS were also assessed. The Beck Depression Inventory assessed depressive symptoms and the SF-36 assessed health-related quality of life. Data were analyzed using general linear models. Results: BMI decreased at T2 and T3 (T1: 0.3, T2: -0.7, T3: -1.9). The most significant improvement in diet quality was observed at T3. Cardiovascular risk decreased at T2 and T3. Mean reductions in MetS severity score were: -0.02 at T1, -0.39 at T2 and -0.78 at T3. The perception of physical health increases in successive tertiles. Conclusions: In older adults with MetS, more ambitious desired weight loss goals were associated with improvements in diet, cardiovascular health and perceived physical health during the first year of a healthy lifestyle intervention programme. Weight dissatisfaction needs to be considered by health professionals.
C1 [Bouzas, Cristina; Bibiloni, Maria del Mar; Garcia, Silvia; Mateos, David; Martinez-Gonzalez, Miguel Angel; Salas-Salvado, Jordi; Corella, Dolores; Goday, Albert; Martinez, J. Alfredo; Alonso-Gomez, Angel M.; Waernberg, Julia; Romaguera, Dora; Lopez-Miranda, Jose; Estruch, Ramon; Tinahones, Francisco J.; Lapetra, Jose; Serra-Majem, Lluis; Pinto, Xavier; Ros, Emilio; Babio, Nancy; Castaner, Olga; Abete, Itziar; Sorto-Sanchez, Carolina; Carlos Benavente-Marin, Juan; Martin, Marian; Garcia-Rios, Antonio; Castro-Barquero, Sara; Fernandez-Garcia, Jose C.; Santos-Lozano, Jose Manuel; Salas-Huetos, Albert; Guillem-Saiz, Patricia; Zomeno, Maria Dolores; angeles Zulet, Maria; Goikoetxea-Bahon, Amaia; Nishi, Stephanie K.; Tur, Josep A.] Inst Salud Carlos III ISCIII, CIBER Fisiopatol Obes & Nutr CIBEROBN, Madrid, Spain.
   [Bouzas, Cristina; Bibiloni, Maria del Mar; Garcia, Silvia; Mateos, David; Tur, Josep A.] Univ Balear Isl, Res Grp Community Nutr & Oxidat Stress, Palma De Mallorca, Spain.
   [Bouzas, Cristina; Bibiloni, Maria del Mar; Garcia, Silvia; Mateos, David; Romaguera, Dora; Martin, Marian; Tur, Josep A.] Hlth Res Inst Balear Isl IdISBa, Palma De Mallorca, Spain.
   [Martinez-Gonzalez, Miguel Angel; Pascual-Roquet-Jalmar, Elena; Abete, Itziar; Fernandez-Lazaro, Cesar I.; angeles Zulet, Maria; Gea, Alfredo] Univ Navarra, Dept Prevent Med & Publ Hlth, Inst Invest Sanitaria Navarra IDISNA, Pamplona, Spain.
   [Martinez-Gonzalez, Miguel Angel] Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA.
   [Salas-Salvado, Jordi; Babio, Nancy; Salas-Huetos, Albert; Nishi, Stephanie K.] Univ Rovira & Virgili, Tarragona, Spain.
   [Corella, Dolores; Gonzalez-Monge, Inmaculada; Guillem-Saiz, Patricia] Univ Valencia, Dept Prevent Med, Valencia, Spain.
   [Goday, Albert; Castaner, Olga; Zomeno, Maria Dolores; Schroeder, Helmut] Inst Hosp Mar Invest Med Municipal Invest Med IMIM, Unit Cardiovasc Risk & Nutr, Barcelona, Spain.
   [Martinez, J. Alfredo] Inst Madrileno Estudios Avanzados IMDEA Food, Cardiometab Precis Nutr Program, Campus Excelencia Int CEI UAM CSIC, Madrid, Spain.
   [Martinez, J. Alfredo] Univ Navarra, Ctr Nutr Res, Dept Nutr Food Sci & Physiol, Pamplona, Spain.
   [Alonso-Gomez, Angel M.; Sorto-Sanchez, Carolina; Goikoetxea-Bahon, Amaia] Bioaraba Hlth Res Inst, Vitoria, Spain.
   [Alonso-Gomez, Angel M.; Sorto-Sanchez, Carolina; Goikoetxea-Bahon, Amaia] Araba Univ Hosp, Osakidetza Basque Hlth Serv, Vitoria, Spain.
   [Alonso-Gomez, Angel M.; Sorto-Sanchez, Carolina; Goikoetxea-Bahon, Amaia] Univ Basque Country, Univ Pais Vasco Euskal Herriko Unibertsitatea UPV, Dept Med, Vitoria, Spain.
   [Waernberg, Julia; Gaforio, Jose J.; Carlos Benavente-Marin, Juan] Univ Malaga, Sch Hlth Sci, Dept Nursing, IBIMA, Malaga, Spain.
   [Vioque, Jesus; Torres-Collado, Laura] Inst Invest Sanitaria & Biomed Alicante ISABIAL UM, Inst Invest Sanitaria & Biomed Alicante, Alicante, Spain.
   [Vioque, Jesus; Riquelme-Gallego, Blanca; Torres-Collado, Laura; Schroeder, Helmut] Inst Salud Carlos III ISCIII, CIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain.
   [Lopez-Miranda, Jose; Garcia-Rios, Antonio] Univ Cordoba, Reina Sofia Univ Hosp, Maimonides Biomed Res Inst Cordoba IMIB, Dept Internal Med,Lipids & Atherosclerosis Unit, Cordoba, Argentina.
   [Estruch, Ramon; Castro-Barquero, Sara] Univ Barcelona, Hosp Clin, Inst Invest Biomed August Pi & Sunyer IDIBAPS, Dept Internal Med, Barcelona, Spain.
   [Tinahones, Francisco J.; Fernandez-Garcia, Jose C.] Univ Malaga, Virgen Victoria Hosp, Dept Endocrinol, Malaga, Spain.
   [Lapetra, Jose; Santos-Lozano, Jose Manuel] Dept Family Med, Res Unit, Dist Sanitario Atenc Primaria Sevilla, Seville, Spain.
   [Serra-Majem, Lluis] Univ Las Palmas Gran Canaria, Inst Biomed Res, Las Palmas Gran Canaria, Spain.
   [Riquelme-Gallego, Blanca] Univ Granada, Dept Prevent Med, Granada, Spain.
   [Martin-Sanchez, Vicente] Inst Salud Carlos III ISCIII, CIBER Diabet & enfermedades Metab CIBERDEM, Madrid, Spain.
   [Martin-Sanchez, Vicente] Univ Leon, Inst Biomed IBIOMED, Leon, Spain.
   [Pinto, Xavier] Hosp Univ Bellvitge, Lipids & Vasc Risk Unit, Internal Med, Barcelona, Spain.
   [Gaforio, Jose J.] Univ Jaen, Ctr Adv Studies Olive Grove & Olive Oils, Dept Hlth Sci, Jaen, Spain.
   [Matia, Pilar] Fdn Invest Biomed Hosp Clin San Carlos IdISSC, Dept Endocrinol & Nutr, Madrid, Spain.
   [Vidal, Josep] Univ Barcelona, Hosp Clin, Inst Invest Biomed August Pi Sunyer IDIBAPS, Dept Endocrinol, Barcelona, Spain.
   [Vazquez, Clotilde] Fdn Jimenez Diaz, Dept Endocrinol, Madrid, Spain.
   [Daimiel, Lidia] Campus Excelencia Int CEI UAM CSIC, Precis Nutr & Obes Program, Nutr Control Epigenome Grp, IMDEA Food, Madrid, Spain.
   [Ros, Emilio] Hosp Clin Barcelona, Inst Invest Biomed August Pi Sunyer IDIBAPS, Dept Endocrinol & Nutr, Lipid Clin, Barcelona, Spain.
   [Pascual-Roquet-Jalmar, Elena] Serv Navarro Salud, Osasunbidea, Atenc Primaria, Pamplona, Spain.
C3 CIBER - Centro de Investigacion Biomedica en Red; CIBEROBN; Universitat
   de les Illes Balears; Institut Investigacio Sanitaria Illes Balears
   (IdISBa); University of Navarra; Harvard University; Harvard T.H. Chan
   School of Public Health; Universitat Rovira i Virgili; University of
   Valencia; IMDEA Food Institute; University of Navarra; Bioaraba Health
   Research Institute; University Hospital of Araba; University of Basque
   Country; Universidad de Malaga; Instituto de Investigacion Biomedica de
   Malaga y Plataforma en Nanomedicina (IBIMA); CIBER - Centro de
   Investigacion Biomedica en Red; CIBERESP; National University of
   Cordoba; University of Barcelona; Hospital Clinic de Barcelona; IDIBAPS;
   Universidad de Malaga; Universidad de Las Palmas de Gran Canaria;
   University of Granada; CIBER - Centro de Investigacion Biomedica en Red;
   CIBERDEM; Universidad de Leon; University of Barcelona; Institut
   d'Investigacio Biomedica de Bellvitge (IDIBELL); Bellvitge University
   Hospital; Universidad de Jaen; University of Barcelona; Hospital Clinic
   de Barcelona; IDIBAPS; IMDEA Food Institute; University of Barcelona;
   Hospital Clinic de Barcelona; IDIBAPS; Servicio Navarro de Salud -
   Osasunbidea
RP Tur, JA (corresponding author), Inst Salud Carlos III ISCIII, CIBER Fisiopatol Obes & Nutr CIBEROBN, Madrid, Spain.; Tur, JA (corresponding author), Univ Balear Isl, Res Grp Community Nutr & Oxidat Stress, Palma De Mallorca, Spain.; Tur, JA (corresponding author), Hlth Res Inst Balear Isl IdISBa, Palma De Mallorca, Spain.
EM pep.tur@uib.es
RI Pintó, Xavier/AGI-4297-2022; Tur, Josep/AAE-5748-2020; Mateos,
   David/N-7366-2018; Warnberg, Julia/G-1390-2011; RIQUELME GALLEGO,
   BLANCA/AAB-1710-2020; Nishi, Stephanie/GSN-1143-2022; Serra-Majem,
   Lluis/I-6708-2019; Sureda, Antoni/N-9588-2019; Vioque,
   Jesus/A-1066-2008; Lopez-Miranda, Jose/Y-8306-2019; Martinez,
   Juan/GXM-4393-2022; Castaner, Olga/F-1533-2013; Romaguera,
   Dora/ABE-7004-2020; Martinez-Gonzalez, Miguel/AAE-7669-2019;
   Daimiel-Ruiz, Lidia/M-7779-2014; Fernandez-Garcia, Jose/B-5312-2013;
   Corella, Dolores/L-9888-2014; ALONSO GOMEZ, ANGEL/HLG-2476-2023;
   Estruch, Ramon/AAZ-3723-2020; Bouzas, Cristina/AAE-2069-2019; Lapetra,
   Jose/F-2552-2015; Fernandez-Lazaro, Cesar/V-6390-2019; Babio,
   Nancy/AAN-2715-2020; Abad-Gurumeta, Alfredo/M-2337-2019; Tinahones,
   Francisco/AAB-2882-2020; Vidal, Josep/MIK-6936-2025; Salas-Salvado,
   Jordi/C-7229-2017; Martin, Vicente/A-1597-2008; Salas-Huetos,
   Albert/A-8509-2011; Schroder, Helmut/G-2586-2015
OI Benavente Marin, Juan Carlos/0000-0002-4037-0239; Riquelme Gallego,
   Blanca/0000-0003-3422-7310; Salas-Salvado, Jordi/0000-0003-2700-7459;
   Martin, Vicente/0000-0003-0552-2804; BABIO SANCHEZ,
   NANCY/0000-0003-3527-5277; Vioque, Jesus/0000-0002-2284-148X; Tercero
   Macia, Cristina/0009-0000-6092-9231; Tinahones, Francisco
   J/0000-0001-6871-4403; Salas-Huetos, Albert/0000-0001-5914-6862;
   Schroder, Helmut/0000-0003-2231-5081; Guillem Saiz,
   Patricia/0000-0003-4422-5538; Nishi, Stephanie/0000-0002-7878-5368;
   Lopez-Miranda, Jose/0000-0002-8844-0718
FU European Research Council [20132018, 340918]; Spanish government,
   ISCIII, through the Fondo de Investigacion para la Salud (FIS) -
   European Regional Development Fund [PI13/00673, PI13/00492, PI13/00272,
   PI13/01123, PI13/00462, PI13/00233, PI13/02184, PI13/00728, PI13/01090,
   PI13/01056, PI14/01722, PI14/00636, PI14/00618, PI14/00696, PI14/01206,
   PI14/01919]; Especial Action Project entitled: Implementacion y
   evaluacion de una intervencion intensive sobre la actividad fisica
   Cohorte PREDIMED-Plus grant; Recercaixa Grant [2013ACUP00194];
   Consejeria de Salud de la Junta de Andalucia [PI0458/2013, PS0358/2016,
   PI0137/2018]; Generalitat Valenciana [PROMETEO/2017/017]; EU-COST Action
   [CA16112]; Balearic Islands Health Research Institute (IDISBA); European
   Regional Development Fund [CIBEROBN CB06/03, CB12/03]; European
   Commission [EAT2BENICE_H2020_SFS2016]; Fundacio La Marato TV3
   [201630.10]; Fernando Tarongi Bauza Grant; 'Spanish government, ISCIII,
   through the Fondo de Investigacion para la Salud (FIS) - European
   Regional Development Fund' [PI17/00855, PI17/01347, PI17/00525,
   PI17/01827, PI17/00532, PI17/00215, PI17/01441, PI17/00508, PI17/01732,
   PI17/00926, PI19/00957, PI19/00386, PI19/00309, PI19/01032, PI19/00576,
   PI19/00017]; the Spanish government, ISCIII, through the Fondo de
   Investigacion para la Salud (FIS) - European Regional Development Fund
   [PI14/00853, PI14/01374, PI14/00972, PI14/00728, PI14/01471, PI16/00473,
   PI16/00662, PI16/01873, PI16/01094, PI16/00501, PI16/00533, PI16/00381,
   PI16/00366, PI16/01522, PI16/01120, PI17/00764, PI17/01183, PI19/01226];
   "Spanish government, ISCIII, through the Fondo de Investigacion para la
   Salud (FIS) - European Regional Development Fund" [PI19/00781,
   PI19/01560, PI19/01332, PI20/01802, PI20/00138, PI20/01532, PI20/00456,
   PI20/00339, PI20/00557, PI20/00886, PI20/01158]
FX The PREDIMED-Plus trial was supported by the European Research Council
   (Advanced Research Grant 20132018, 340918) to MA and the official
   funding agency for biomedical research of the Spanish government,
   ISCIII, through the Fondo de Investigacion para la Salud (FIS), which is
   co-funded by the European Regional Development Fund (five coordinated
   FIS projects led by JS-S and JVid, including the following projects:
   PI13/00673, PI13/00492, PI13/00272, PI13/01123, PI13/00462, PI13/00233,
   PI13/02184, PI13/00728, PI13/01090, PI13/01056, PI14/01722, PI14/00636,
   PI14/00618, PI14/00696, PI14/01206, PI14/01919, PI14/00853, PI14/01374,
   PI14/00972, PI14/00728, PI14/01471, PI16/00473, PI16/00662, PI16/01873,
   PI16/01094, PI16/00501, PI16/00533, PI16/00381, PI16/00366, PI16/01522,
   PI16/01120, PI17/00764, PI17/01183, PI17/00855, PI17/01347, PI17/00525,
   PI17/01827, PI17/00532, PI17/00215, PI17/01441, PI17/00508, PI17/01732,
   PI17/00926, PI19/00957, PI19/00386, PI19/00309, PI19/01032, PI19/00576,
   PI19/00017, PI19/01226, PI19/00781, PI19/01560, PI19/01332, PI20/01802,
   PI20/00138, PI20/01532, PI20/00456, PI20/00339, PI20/00557, PI20/00886,
   and PI20/01158), the Especial Action Project entitled: Implementacion y
   evaluacion de una intervencion intensive sobre la actividad fisica
   Cohorte PREDIMED-Plus grant to JS-S, the Recercaixa Grant to JS-S
   (2013ACUP00194), Grants from the Consejeria de Salud de la Junta de
   Andalucia (PI0458/2013, PS0358/2016, and PI0137/2018), a Grant from the
   Generalitat Valenciana (PROMETEO/2017/017), a SEMERGEN Grant, EU-COST
   Action CA16112, Grants (FOLIUM, PRIMUS, SYNERGIA, and LIBERI) from the
   Balearic Islands Health Research Institute (IDISBA), funds from the
   European Regional Development Fund (CIBEROBN CB06/03 and CB12/03), and
   from the European Commission (EAT2BENICE_H2020_SFS2016). Fundacio La
   Marato TV3 (project ref. 201630.10). Cristina Bouzas received a Fernando
   Tarongi Bauza Grant. The funding sponsors had no role in the design of
   the study, in the collection, analyses, or interpretation of the data;
   in the writing of the manuscript, and in the decision to publish the
   results.
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NR 63
TC 2
Z9 2
U1 1
U2 18
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD JUL 22
PY 2022
VL 9
AR 848055
DI 10.3389/fnut.2022.848055
PG 14
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 3P3AK
UT WOS:000837409900001
PM 35938116
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Lee, JY
   Han, K
   Kim, J
   Lim, JS
   Cheon, DY
   Lee, M
AF Lee, Jeong-Yoon
   Han, Kyungdo
   Kim, Jonguk
   Lim, Jae-Sung
   Cheon, Dae Young
   Lee, Minwoo
TI Association Between Metabolic Syndrome and Young-Onset Dementia
SO NEUROLOGY
LA English
DT Article
ID RISK; INFLAMMATION; DIAGNOSIS; COGNITION; PROFILE
AB Background and ObjectivesYoung-onset dementia (YOD) poses substantial societal and health care burdens. Although metabolic syndrome (MetS) is recognized as a contributor to late-onset dementia, its effect on YOD remains unclear. This study aimed to determine whether MetS and its individual components increase the risk of YOD, including all-cause dementia, Alzheimer disease (AD), and vascular dementia (VaD).MethodsWe conducted a nationwide population-based cohort study using data from the Korean National Insurance Service. Individuals aged 40-60 who underwent national health check-ups in 2009 were included and followed until December 31, 2020, or age 65, whichever came first. MetS was defined according to established guidelines, incorporating measurements of waist circumference, blood pressure, fasting glucose, triglycerides, and high-density lipoprotein cholesterol. Covariates included age, sex, income level, smoking status, alcohol consumption, and comorbidities such as hypertension, diabetes, dyslipidemia, and depression. The primary outcome was incident all-cause YOD, defined as a dementia diagnosis before age 65; secondary outcomes included young-onset AD and VaD. Multivariable Cox proportional hazards models were used to estimate hazard ratios (HRs) with 95% CIs.ResultsA total of 1,979,509 participants (mean age, 49.0 years; 51.3% men; 50.7% with MetS) were included. Over an average follow-up of 7.75 years, 8,921 individuals (0.45%) developed YOD. MetS was associated with a 24% higher risk of all-cause YOD (adjusted HR 1.24, 95% CI 1.19-1.30), a 12.4% increased risk of AD (HR 1.12, 95% CI 1.03-1.22), and a 20.9% increased risk of VaD (HR 1.21, 95% CI 1.08-1.35). Significant interactions were noted with younger age (40-49 vs 50-59), female sex, drinking status, obesity, and depression.DiscussionIn this large Korean cohort, MetS and its individual components were significantly associated with an increased risk of YOD. These findings suggest that interventions targeting MetS may help mitigate YOD risk. However, the observational design precludes definitive causal inferences, and reliance on claims data could introduce misclassification bias. Future research using longitudinal designs and comprehensive data collection is needed to validate and expand on these associations.
C1 [Lee, Jeong-Yoon] Soonchunhyang Univ, Seoul Hosp, Coll Med, Dept Neurol, Seoul, South Korea.
   [Han, Kyungdo] Soongsil Univ, Dept Stat & Actuarial Sci, Seoul, South Korea.
   [Kim, Jonguk] Inha Univ, Inha Univ Hosp, Coll Med, Incheon, South Korea.
   [Lim, Jae-Sung] Ulsan Univ, Coll Med, Asan Med Ctr, Dept Neurol, Seoul, South Korea.
   [Cheon, Dae Young] Hallym Univ, Dongtan Sacred Heart Hosp, Dept Internal Med, Div Cardiol, Hwaseong, South Korea.
   [Lee, Minwoo] Hallym Univ, Sacred Heart Hosp, Dept Neurol, Anyang, South Korea.
C3 Soonchunhyang University; Soongsil University; Inha University; Inha
   University Hospital; University of Ulsan; Asan Medical Center; Hallym
   University; Hallym University
RP Cheon, DY (corresponding author), Hallym Univ, Dongtan Sacred Heart Hosp, Dept Internal Med, Div Cardiol, Hwaseong, South Korea.; Lee, M (corresponding author), Hallym Univ, Sacred Heart Hosp, Dept Neurol, Anyang, South Korea.
EM arkad86@hanmail.net; neuromlee@hallym.or.kr
RI Lim, Jae-Sung/D-5555-2012; Cheon, Dae Young/LRD-0217-2024
FU Bio and Medical Technology Development Program of the National Research
   Foundation - Korean government (MSIT) [RS-2023-00223501]
FX This research was supported by the Bio and Medical Technology
   Development Program of the National Research Foundation funded by the
   Korean government (MSIT) (No.RS-2023-00223501).
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NR 42
TC 0
Z9 0
U1 1
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0028-3878
EI 1526-632X
J9 NEUROLOGY
JI Neurology
PD MAY 27
PY 2025
VL 104
IS 10
AR e213599
DI 10.1212/WNL.0000000000213599
PG 12
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 2DY8Z
UT WOS:001480378100001
PM 40267374
DA 2025-06-11
ER

PT J
AU Liu, W
   Wu, Y
   Hu, YL
   Qin, S
   Guo, XY
   Wang, MH
   Wu, LL
   Liu, TH
AF Liu, Wei
   Wu, You
   Hu, Yuli
   Qin, Shuai
   Guo, Xiaoyuan
   Wang, Minghui
   Wu, Lili
   Liu, Tonghua
TI Effects of Cyclocarya paliurus Aqueous and Ethanol Extracts on
   Glucolipid Metabolism and the Underlying Mechanisms: A Meta-Analysis and
   Systematic Review
SO FRONTIERS IN NUTRITION
LA English
DT Review
DE Cyclocarya paliurus; metabolic syndrome; insulin resistance;
   dyslipidemia; hyperglycemia; glucolipid metabolism
ID OXIDATIVE STRESS; CHEMICAL-COMPOSITION; INSULIN-RESISTANCE; BATAL.
   ILJINSKAJA; INFLAMMATION; OBESITY; FAT; POLYSACCHARIDE; LEAVES;
   DYSFUNCTION
AB Background and Aims: Cyclocarya paliurus (CP) has been used as an herbal tea to treat diabetes mellitus and obesity for hundreds of years. Previous research suggests that CP specifically restores glucolipid metabolic homeostasis, and the two most studied preparations are aqueous and ethanol extracts. In order to verify the effect of CP on glucolipid metabolism in animal models with metabolic syndrome, a meta-analysis was performed, and the active components and underlying mechanisms were systematically reviewed.
   Methods: Four databases: PubMed, Web of Science, Embase, and Cochrane Library were searched to identify potential literature. Data of blood glucose (BG) level, area under curve (AUC) of oral glucose tolerance test (OGTT), total cholesterol (TC), triglyceride (TG), high-density lipoprotein (HDL), and low-density lipoprotein (LDL) levels were extracted as indicators of the assessment of CP's effects. Follow-up analyses including subgroup analysis, meta-regressions, and publication bias were also conducted.
   Results: A total of 96 papers were identified from the databases and 11 papers including 31 data reports were involved in the meta-analysis. CP had a positive effect in down-regulating BG, AUC of OGTT, TC, TG, and LDL, and up-regulating HDL (P < 0.001, 95% confidence interval of standard mean difference did not incorporate the null value 0).
   Conclusion: CP showed definite activity of regulating glucolipid metabolism in animal models, and it exerted its function through multiple mechanisms including but not limited to: (1) improving insulin resistance; (2) protecting pancreatic beta cells; (3) decreasing inflammatory infiltration; and (4) anti-oxidative stress.
C1 [Liu, Wei; Wu, You; Hu, Yuli; Wu, Lili; Liu, Tonghua] Beijing Univ Chinese Med, Key Lab Hlth Cultivat, Minist Educ, Beijing, Peoples R China.
   [Liu, Wei; Wu, You; Hu, Yuli; Guo, Xiaoyuan] Beijing Univ Chinese Med, Dongfang Hosp, Beijing, Peoples R China.
   [Qin, Shuai] Guizhou Univ Tradit Chinese Med, Sch Clin Med 1, Guiyang, Peoples R China.
   [Wang, Minghui] Chengdu Integrated TCM & Western Med Hosp, Chengdu, Peoples R China.
C3 Ministry of Education - China; Beijing University of Chinese Medicine;
   Beijing University of Chinese Medicine; Guizhou University of
   Traditional Chinese Medicine
RP Wu, LL; Liu, TH (corresponding author), Beijing Univ Chinese Med, Key Lab Hlth Cultivat, Minist Educ, Beijing, Peoples R China.
EM qingniao_566@163.com; thliu@vip.163.com
RI liu, th/KBQ-0635-2024; Guo, Xiaoyuan/AAP-1101-2021; Wu,
   You/AAG-2495-2021
OI Wu, You/0000-0002-0179-8865
FU Creation and Talent Introduction Base of Prevention and Treatment of
   Diabetes and Its Complications with Traditional Chinese Medicine
   [B20055]
FX This work was supported by the Creation and Talent Introduction Base of
   Prevention and Treatment of Diabetes and Its Complications with
   Traditional Chinese Medicine (Grant No. B20055).
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NR 65
TC 9
Z9 9
U1 4
U2 56
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD DEC 1
PY 2020
VL 7
AR 605605
DI 10.3389/fnut.2020.605605
PG 17
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA PE6XF
UT WOS:000598506400001
PM 33335910
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Zhang, XM
   Guo, L
   Huang, X
   Li, QM
   Chi, MH
AF Zhang, Xi-Mei
   Guo, Lin
   Huang, Xiang
   Li, Qiu-Ming
   Chi, Mei-Hua
TI 4-Hydroxynonenal Regulates TNF-α Gene Transcription Indirectly via ETS1
   and microRNA-29b in Human Adipocytes Induced From Adipose Tissue-Derived
   Stromal Cells
SO ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY
   BIOLOGY
LA English
DT Article
DE miRNA; adipose stem cells; stromal cells; obesity; inflammation
ID NECROSIS-FACTOR-ALPHA; INSULIN-RESISTANCE; HUMAN OBESITY; INFLAMMATION;
   EXPRESSION; ADIPOKINES
AB Obesity is characterized by an accumulation of excessive body fat and can be diagnosed by a variety of measures, such as BMI. However, in some obese individuals, oxidative stress is also thought to be an important pathogenic mechanism of obesity-associated metabolic syndrome. Oxidative stress increases the lipid peroxidation product, 4-hydroxynonenal (4-HNE), which is one of the most abundant and active lipid peroxides. Within the adipose tissue, adipocytes are derived from adipose tissue-derived stromal cells (ADSCs), which play a key role in the generation and metabolism of adipose tissue. Additionally, obesity is associated with low-grade inflammation. Specific microRNAs (miRNAs) that regulate obesity-associated inflammation are largely dysregulated in metabolic syndrome (MS). In this study, we aim to confirm whether 4-HNE and miRNAs play a role in the regulation of TNF-alpha gene transcription. We enrolled six obese individuals who were referred to Harbin Medical University (Heilongjiang, China) and six nonobese control participants. Plasma 4-HNE levels of the 12 subjects were determined by ELISA. Using qRT-PCR, we measured ETS1, miR-29b, SP1, and TNF-alpha levels in subcutaneous white adipose tissue (WAT). Furthermore, we examined the relationship between ETS1 and TNF-alpha using a luciferase reporter assay and a ChIP assay. Our results suggest that ETS1 promotes TNF-alpha gene transcription in adipocytes. In addition, we demonstrated that 4-HNE promotes TNF-alpha gene transcription through the inhibition of the miR-29b -> SP1 -> TNF-alpha pathway and promotion of the ETS1 -> TNF-alpha pathway. Anat Rec, 299:1145-1152, 2016. (C) 2016 Wiley Periodicals, Inc.
C1 [Zhang, Xi-Mei; Huang, Xiang; Li, Qiu-Ming] Harbin Med Univ, Dept Histol & Embryol, 157 Baojian Rd, Harbin 150081, Peoples R China.
   [Guo, Lin] Harbin Med Univ, Dept Endocrinol & Metab, Affiliated Hosp 1, Harbin 150081, Peoples R China.
   [Chi, Mei-Hua] Harbin Med Univ, Teaching Expt Ctr Morphol, Harbin 150081, Peoples R China.
C3 Harbin Medical University; Harbin Medical University; Harbin Medical
   University
RP Zhang, XM (corresponding author), Harbin Med Univ, Dept Histol & Embryol, 157 Baojian Rd, Harbin 150081, Peoples R China.
EM ximei1119@126.com
FU Natural Science Foundation of China [81302420]; Heilongjiang Province
   Study Abroad Returnees Science Fund [LC2015028]; Postdoctoral Scientific
   Research Developmental Fund of Heilongjiang Province [LBH-Q15084]
FX Grant sponsor: Natural Science Foundation of China; Grant number:
   81302420; Grant sponsor: Heilongjiang Province Study Abroad Returnees
   Science Fund; Grant number: LC2015028; Grant sponsor: Postdoctoral
   Scientific Research Developmental Fund of Heilongjiang Province; Grant
   number: LBH-Q15084.
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NR 20
TC 18
Z9 20
U1 0
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1932-8486
EI 1932-8494
J9 ANAT REC
JI Anat. Rec.
PD AUG
PY 2016
VL 299
IS 8
BP 1145
EP 1152
DI 10.1002/ar.23371
PG 8
WC Anatomy & Morphology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Anatomy & Morphology
GA DT7BU
UT WOS:000381641900017
PM 27164408
OA Bronze
DA 2025-06-11
ER

PT J
AU Higuchi, M
   Dusting, GJ
   Peshavariya, H
   Jiang, F
   Hsiao, STF
   Chan, EC
   Liu, GS
AF Higuchi, Masayoshi
   Dusting, Gregory J.
   Peshavariya, Hitesh
   Jiang, Fan
   Hsiao, Sarah Tzu-Feng
   Chan, Elsa C.
   Liu, Guei-Sheung
TI Differentiation of Human Adipose-Derived Stem Cells into Fat Involves
   Reactive Oxygen Species and Forkhead Box O1 Mediated Upregulation of
   Antioxidant Enzymes
SO STEM CELLS AND DEVELOPMENT
LA English
DT Article
ID TRANSCRIPTION FACTOR FOXO1; ADIPOCYTE DIFFERENTIATION; OXIDATIVE STRESS;
   CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; OBESITY; IMPACT; FKHR; AKT
AB Both reactive oxygen species (ROS) and Forkhead box O (FOXO) family transcription factors are involved in the regulation of adipogenic differentiation of preadipocytes and stem cells. While FOXO has a pivotal role in maintaining cellular redox homeostasis, the interactions between ROS and FOXO during adipogenesis are not clear. Here we examined how ROS and FOXO regulate adipogenesis in human adipose-derived stem cells (hASC). The identity of isolated cells was confirmed by their surface marker expression pattern typical for human mesenchymal stem cells (positive for CD29, CD44, CD73, CD90, and CD105, negative for CD45 and CD31). Using a standard adipogenic cocktail consisting of insulin, dexamethasone, indomethacin, and 3-Isobutyl-1-methylanxthine (IDII), adipogenesis was induced in hASC, which was accompanied by ROS generation. Scavenging ROS production with N-acetyl-L-cysteine or EUK-8, a catalytic mimetic of superoxide dismutase (SOD) and catalase, inhibited IDII-induced adipogenesis. We then mimicked IDII-induced oxidative stress through a lentiviral overexpression of Nox4 and an exogenous application of hydrogen peroxide in hASC and both manipulations significantly enhanced adipogenesis without changing the adipogenic differentiation rate. These data suggest that ROS promoted lipid accumulation in hASC undergoing adipogenesis. Antioxidant enzymes, including SOD2, catalase, and glutathione peroxidase were upregulated by IDII during adipogenesis, and these effects were blunted by FOXO1 silencing, which also suppressed significantly IDII-induced adipogenesis. Our findings demonstrated a balance of ROS generation and endogenous antioxidants in cells undergoing adipogenesis. Approaches targeting ROS and/or FOXO1 in adipocytes may bring new strategies to prevent and treat obesity and metabolic syndrome.
C1 [Higuchi, Masayoshi; Dusting, Gregory J.; Peshavariya, Hitesh; Chan, Elsa C.; Liu, Guei-Sheung] Ctr Eye Res Australia, Melbourne, Vic 3002, Australia.
   [Higuchi, Masayoshi; Dusting, Gregory J.; Peshavariya, Hitesh; Hsiao, Sarah Tzu-Feng; Chan, Elsa C.; Liu, Guei-Sheung] OBrien Inst, Fitzroy, Vic, Australia.
   [Dusting, Gregory J.; Hsiao, Sarah Tzu-Feng] Univ Melbourne, Dept Surg, Melbourne, Vic 3010, Australia.
   [Jiang, Fan] Shandong Univ, Chinese Minist Educ, Key Lab Cardiovasc Remodeling & Funct Res, Jinan 250100, Peoples R China.
   [Jiang, Fan] Shandong Univ, Chinese Minist Hlth, Qilu Hosp, Jinan 250100, Peoples R China.
C3 Centre for Eye Research Australia; O'Brien Institute; University of
   Melbourne; Ministry of Education - China; Shandong University; Shandong
   University
RP Liu, GS (corresponding author), Ctr Eye Res Australia, 1-32 Gisborne St, Melbourne, Vic 3002, Australia.
EM guei-sheung.liu@unimelb.edu.au
RI Jiang, Fan/B-7753-2013; Hsiao, Sarah/P-3955-2018; Liu,
   Guei-Sheung/Q-6472-2018
OI Hsiao, Sarah/0000-0002-8455-2763; Liu, Guei-Sheung/0000-0003-3379-724X
FU National Health and Medical Research Council of Australia [NHMRC
   09007G]; JO&JR Wicking Trust; National Natural Science Foundation of
   China [NSFC81070164]; NHMRC
FX This work was supported by project grants from the National Health and
   Medical Research Council of Australia (NHMRC 09007G) (G. L.), the JO&JR
   Wicking Trust, and the National Natural Science Foundation of China
   (NSFC81070164) (F. J.). G. J. D. is supported by a principal research
   fellowship from NHMRC. Centre for Eye Research Australia and O'Brien
   Institute acknowledges the Victorian State Government's Department of
   Innovation, Industry and Regional Development's Operational
   Infrastructure Support Program.
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NR 39
TC 173
Z9 186
U1 1
U2 29
PU MARY ANN LIEBERT INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1547-3287
J9 STEM CELLS DEV
JI Stem Cells Dev.
PD MAR
PY 2013
VL 22
IS 6
BP 878
EP 888
DI 10.1089/scd.2012.0306
PG 11
WC Cell & Tissue Engineering; Hematology; Medicine, Research &
   Experimental; Transplantation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Hematology; Research & Experimental Medicine;
   Transplantation
GA 098YC
UT WOS:000315584000005
PM 23025577
OA Green Published
DA 2025-06-11
ER

PT J
AU Boccara, F
   Auclair, M
   Cohen, A
   Lefèvre, C
   Prot, M
   Bastard, JP
   Capeau, J
   Caron-Debarle, M
AF Boccara, Franck
   Auclair, Martine
   Cohen, Ariel
   Lefevre, Chloe
   Prot, Mathieu
   Bastard, Jean-Philippe
   Capeau, Jacqueline
   Caron-Debarle, Martine
TI HIV protease inhibitors activate the adipocyte renin angiotensin system
SO ANTIVIRAL THERAPY
LA English
DT Article
ID PPAR-GAMMA AGONIST; INSULIN-RESISTANCE; ADIPOSE-TISSUE; ANTIRETROVIRAL
   THERAPY; METABOLIC SYNDROME; RECEPTOR BLOCKERS; TYPE-1 RECEPTOR;
   ALDOSTERONE SYSTEM; OXIDATIVE STRESS; FAT DISTRIBUTION
AB Background: HIV-infected patients under antiretroviral therapy that includes HIV protease inhibitors (PIs) are prone to develop a complex metabolic syndrome including insulin resistance, lipodystrophy and hypertension. Whether hypertension and cardiovascular events could result from the adipocyte renin angiotensin system (RAS) overactivation has never been investigated.
   Methods: Primary human adipocytes and 3T3-F442A murine adipocytes were incubated with lopinavir or atazanavir boosted with ritonavir, with or without the angiotensin II type-1 receptor (AT1R) blockers (ARBs), irbesartan or telmisartan, and the peroxysome proliferator-activated receptor-gamma (PPAR-gamma) regulators, rosiglitazone and GW9662. Adipose RAS activation and adipocyte functions were evaluated.
   Results: The ritonavir-boosted Pis activated the adipose RAS in human and murine adipocytes as shown by the overexpression of AT1R protein, angiotensinogen messenger RNA and the amplified effect of angiotensin II on extracellular signal-regulated kinase 1/2 activity. ARBs prevented the PI effect on RAS activation (AT1R overexpression and signalling) and adipocyte functions (dedifferentiation, insulin resistance, oxidative stress and inflammation). Consistent with a role of PPAR-gamma signalling in PI-induced RAS activation, the PPAR-gamma agonist (rosiglitazone) normalized PI-induced AT1R overexpression and adipocyte dysfunction. Conversely, the PPAR-gamma antagonist (GW9662) induced AT1R overexpression and reduced the beneficial effect of telmisartan on PI toxicity.
   Conclusions: We report that two frequently prescribed PI combinations could activate the adipose RAS in cultured cells, in part through a PPAR-gamma-dependant signalling pathway. Our data suggest a role for the adipose RAS in the development of hypertension in HIV-infected patients under PI treatment, and point out the potential use of ARBs to decrease PI adverse effects.
C1 [Boccara, Franck; Auclair, Martine; Lefevre, Chloe; Prot, Mathieu; Bastard, Jean-Philippe; Capeau, Jacqueline; Caron-Debarle, Martine] INSERM, Fac Med St Antoine, UMR S 938, Paris, France.
   [Boccara, Franck; Auclair, Martine; Cohen, Ariel; Lefevre, Chloe; Prot, Mathieu; Bastard, Jean-Philippe; Capeau, Jacqueline; Caron-Debarle, Martine] UPMC Univ Paris 06, UMR S 938, Paris, France.
   [Boccara, Franck; Cohen, Ariel] Hop St Antoine, AP HP, Dept Cardiol, F-75571 Paris, France.
   [Bastard, Jean-Philippe; Capeau, Jacqueline] Hop Tenon, AP HP, Dept Biochem, F-75970 Paris, France.
C3 Institut National de la Sante et de la Recherche Medicale (Inserm);
   Sorbonne Universite; Sorbonne Universite; Institut National de la Sante
   et de la Recherche Medicale (Inserm); Assistance Publique Hopitaux Paris
   (APHP); Sorbonne Universite; Hopital Universitaire Saint-Antoine - APHP;
   Assistance Publique Hopitaux Paris (APHP); Sorbonne Universite; Hopital
   Universitaire Tenon - APHP
RP Boccara, F (corresponding author), INSERM, Fac Med St Antoine, UMR S 938, Paris, France.
EM franck.boccara@sat.aphp.fr
OI Auclair, Martine/0000-0003-3600-1999
FU Institut National de la Sante et de la Recherche Medicale (INSERM);
   Universite Pierre et Marie Curie (UPMC); Agence Nationale pour la
   Recherche sur le SIDA et les hepatites virales (ANRS); Sidaction and la
   Fondation de France; Boehringer Ingelheim Pharma GmbH Co., KG
FX This work was supported by funds from Institut National de la Sante et
   de la Recherche Medicale (INSERM), Universite Pierre et Marie Curie
   (UPMC), Agence Nationale pour la Recherche sur le SIDA et les hepatites
   virales (ANRS), Sidaction and la Fondation de France, and unrestricted
   grants from Boehringer Ingelheim Pharma GmbH & Co., KG. These
   pharmaceutical firms had no role in the study design, data collection,
   data interpretation or writing of the report. The authors declare no
   competing interests.
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NR 54
TC 51
Z9 51
U1 0
U2 5
PU INT MEDICAL PRESS LTD
PI LONDON
PA 2-4 IDOL LANE, LONDON EC3R 5DD, ENGLAND
SN 1359-6535
J9 ANTIVIR THER
JI Antivir. Ther.
PY 2010
VL 15
IS 3
BP 363
EP 375
DI 10.3851/IMP1533
PG 13
WC Infectious Diseases; Pharmacology & Pharmacy; Virology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases; Pharmacology & Pharmacy; Virology
GA 609PZ
UT WOS:000278670800009
PM 20516556
OA Bronze
DA 2025-06-11
ER

PT J
AU Ojeda, ML
   Nogales, F
   Serrano, A
   Murillo, ML
   Carreras, O
AF Ojeda, Maria Luisa
   Nogales, Fatima
   Serrano, Atejandra
   Murillo, Maria Luisa
   Carreras, Otimpia
TI Selenoproteins and renal programming in metabolic syndrome-exposed rat
   offspring
SO FOOD & FUNCTION
LA English
DT Article
ID OXIDATIVE STRESS; GLUTATHIONE-PEROXIDASE; ANTIOXIDANT ENZYMES;
   BASEMENT-MEMBRANES; DIABETES-MELLITUS; KIDNEY INJURY; SELENIUM;
   EXPRESSION; GESTATION; LIVER
AB Maternal metabolic syndrome (MS) during gestation and lactation leads to several cardiometabolic changes related to selenium (Se) status and selenoprotein expression in offspring. However, little is known about kidney programming and antioxidant selenoprotein status in MS pups. To gain more knowledge on this subject, two experimental groups of dam rats were used: Control (Se: 0.1 ppm) and MS (fructose 65% and Se: 0.1 ppm). At the end of lactation, Se deposits in kidneys, selenoprotein expression (GPx1, GPx3, GPx4 and selenoprotein P), oxidative balance and AMP-activated protein kinase (AMPK) and activated transcriptional factor NF-kappa B expression were measured. Kidney functional parameters, albuminuria, creatinine clearance, aldosteronemia, and water and electrolyte balance, were also evaluated. One week later systolic blood pressure was measured. Lipid peroxidation takes place in the kidneys of MS pups and Se, selenoproteins and NF-kappa B expression increased, while AMPK activation decreased. MS pups have albuminuria and low creatinine clearance which implies glomerular renal impairment with protein loss. They also present hypernatremia and hyperaldosteronemia, together with a high renal Na+ reabsorption, leading to a hypertensive status, which was detected in these animals one week later. Since these alterations seem to be related, at least in part, to oxidative stress, the increase in Se and selenoproteins found in the kidneys of these pups seems to be beneficial, avoiding a higher lipid oxidation. However, in order to analyze the possible global beneficial role of Se in kidneys during MS exposure, more data are necessary to document the relationships between GPx4 and NF-kappa B, and SelP and AMPK in kidneys.
C1 [Ojeda, Maria Luisa; Nogales, Fatima; Serrano, Atejandra; Murillo, Maria Luisa; Carreras, Otimpia] Univ Seville, Dept Physiol, Fac Pharm, Seville 41012, Spain.
C3 University of Sevilla
RP Nogales, F (corresponding author), Univ Seville, Dept Physiol, Fac Pharm, Seville 41012, Spain.
EM fnogales@us.es
RI Nogales, F/B-8562-2019; Ojeda, Luisa/B-8571-2019
OI Nogales, Fatima/0000-0003-4844-2740
FU Andalusian Regional Government
FX Grants from Andalusian Regional Government for its support to CTS-193
   research group.
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NR 56
TC 3
Z9 3
U1 0
U2 11
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PD MAY 1
PY 2020
VL 11
IS 5
BP 3904
EP 3915
DI 10.1039/d0fo00264j
PG 12
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA LU9BG
UT WOS:000538041500009
PM 32342074
DA 2025-06-11
ER

PT J
AU Dludla, PV
   Nyambuya, TM
   Orlando, P
   Silvestri, S
   Mxinwa, V
   Mokgalaboni, K
   Nkambule, BB
   Louw, J
   Muller, CJF
   Tiano, L
AF Dludla, Phiwayinkosi V.
   Nyambuya, Tawanda M.
   Orlando, Patrick
   Silvestri, Sonia
   Mxinwa, Vuyolwethu
   Mokgalaboni, Kabelo
   Nkambule, Bongani B.
   Louw, Johan
   Muller, Christo J. F.
   Tiano, Luca
TI The impact of coenzyme Q10 on metabolic and cardiovascular
   disease profiles in diabetic patients: A systematic review and
   meta-analysis of randomized controlled trials
SO ENDOCRINOLOGY DIABETES & METABOLISM
LA English
DT Review
DE cardiovascular diseases; coenzyme Q(10); diabetes mellitus; heart
   failure; metabolic syndrome; oxidative stress
AB Aims: Coenzyme Q(10) (CoQ10) is well known for its beneficial effects in cardiovascular disease (CVD); however, reported evidence has not been precisely synthesized to better inform on its impact in protecting against cardiovascular-related complications in diabetic patients.
   Materials and Methodology: The current meta-analysis included randomized controlled trials published in the past 5 years reporting on the effect of CoQ10 on metabolic and CVD-related risk profiles in individuals with diabetes or metabolic syndrome. We searched electronic databases such as MEDLINE, Cochrane Library, Scopus and EMBASE for eligible studies. In addition to assessing the risk of bias and quality of evidence, the random and fixed-effect models were used to calculate the standardized mean difference and 95% confidence intervals for metabolic parameters and CVD outcomes.
   Results: Overall, 12 studies met the inclusion criteria, enrolling a total of 650 patients. Although CoQ10 supplementation did not statistically affect all metabolic profiles measured, it significantly reduced CVD-risk-related indexes such as total cholesterol and low-density lipoprotein (LDL) levels in diabetic patients when compared to those on placebo [SMD = 0.13, 95% CI (0.03; 0.23), Chi(2) = 43.62 and I-2 = 29%, P = .07].
   Conclusions: The overall results demonstrated that supplementation with CoQ10 shows an enhanced potential to lower CVD risk in diabetic patients by reducing total cholesterol and LDL. Moreover, the beneficial effects of CoQ10 in lowering the CVD risk are associated with its ameliorative properties against oxidative stress and improving endothelial health.
C1 [Dludla, Phiwayinkosi V.; Louw, Johan; Muller, Christo J. F.] South African Med Res Council, Biomed Res & Innovat Platform, Tygerberg, South Africa.
   [Dludla, Phiwayinkosi V.; Orlando, Patrick; Silvestri, Sonia; Tiano, Luca] Polytech Univ Marche, Dept Life & Environm Sci, Ancona, Italy.
   [Nyambuya, Tawanda M.; Mxinwa, Vuyolwethu; Mokgalaboni, Kabelo; Nkambule, Bongani B.] Univ KwaZulu Natal, Coll Hlth Sci, Sch Lab Med & Med Sci, Durban, South Africa.
   [Nyambuya, Tawanda M.] Namibia Univ Sci & Technol, Fac Hlth & Appl Sci, Dept Hlth Sci, Windhoek, Namibia.
   [Louw, Johan; Muller, Christo J. F.] Univ Zululand, Dept Biochem & Microbiol, Kwa Dlangezwa, South Africa.
   [Muller, Christo J. F.] Stellenbosch Univ, Fac Hlth Sci, Div Med Physiol, Tygerberg, South Africa.
C3 South African Medical Research Council; Marche Polytechnic University;
   University of Kwazulu Natal; Namibia University of Science & Technology;
   University of Zululand; Stellenbosch University
RP Dludla, PV (corresponding author), South African Med Res Council, Biomed Res & Innovat Platform, ZA-7505 Tygerberg, South Africa.
EM pdludla@mrc.ac.za
RI Orlando, Patrick/LSJ-0851-2024; Nkambule, Bongani/ABD-7943-2022;
   Mokgalaboni, Kabelo/ACZ-1282-2022; Nyambuya, Tawanda
   Maurice/GLU-4124-2022; Tiano, Luca/ABC-2341-2020
OI Mokgalaboni, Kabelo/0000-0002-3224-7433; Nyambuya, Tawanda
   Maurice/0000-0002-3288-9524; Louw, Johan/0000-0002-9023-1659; Nkambule,
   Bongani/0000-0001-8846-1992; Mxinwa, Vuyolwethu/0000-0002-7680-4406;
   Dludla, Phiwayinkosi/0000-0001-5965-3610; Tiano,
   Luca/0000-0002-7519-7106; Orlando, Patrick/0000-0002-4203-9611; Muller,
   Christo/0000-0001-6821-2120
FU NIH D43 grant [D43TW010131]
FX BB Nkambule is a University of KwaZulu-Natal Developing Research
   Innovation, Localisation and Leadership in South Africa (DRILL) fellow.
   DRILL is an NIH D43 grant (D43TW010131) awarded to UKZN in 2015 to
   support a research training and induction programme for early career
   academics. The content hereof is the sole responsibility of the authors
   and does not necessarily represent the official views of the funders.
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NR 57
TC 25
Z9 25
U1 0
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
EI 2398-9238
J9 ENDOCRIN DIAB METAB
JI Endocrinol. Diabetes Metab.
PD APR
PY 2020
VL 3
IS 2
AR e00118
DI 10.1002/edm2.118
PG 12
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA VM2XV
UT WOS:000993472300008
PM 32318636
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Urquiaga, I
   Troncoso, D
   Mackenna, MJ
   Urzúa, C
   Pérez, D
   Dicenta, S
   de la Cerda, PM
   Amigo, L
   Carreño, JC
   Echeverría, G
   Rigotti, A
AF Urquiaga, Ines
   Troncoso, Danitza
   Jose Mackenna, Maria
   Urzua, Catalina
   Perez, Druso
   Dicenta, Sara
   Maria de la Cerda, Paula
   Amigo, Ludwig
   Carlos Carreno, Juan
   Echeverria, Guadalupe
   Rigotti, Attilio
TI The Consumption of Beef Burgers Prepared with Wine Grape Pomace Flour
   Improves Fasting Glucose, Plasma Antioxidant Levels, and Oxidative
   Damage Markers in Humans: A Controlled Trial
SO NUTRIENTS
LA English
DT Article
DE antioxidant; dietary intervention; fiber; oxidative damage; wine grape
   pomace
ID TYPE-2 DIABETES-MELLITUS; PROTEIN PRODUCTS; DIETARY FIBER; STOMACH
   MEDIUM; WHOLE GRAINS; HEALTH; DISEASE; NUTRITION; CAPACITY; STRESS
AB Wine grape pomace flour (WGPF) is a fruit byproduct that is high in fiber and antioxidants. We tested whether WGPF consumption could affect blood biochemical parameters, including oxidative stress biomarkers. In a three-month intervention study, 27 male volunteers, each with some components of metabolic syndrome, consumed a beef burger supplemented with 7% WGPF containing 3.5% of fiber and 1.2 mg gallic equivalents (GE)/g of polyphenols (WGPF-burger), daily, during the first month. The volunteers consumed no burgers in the second month, and one control-burger daily in the third month. At baseline and after these periods, we evaluated the metabolic syndrome components, plasma antioxidant status (i.e., 2,2-diphenyl-1-picrylhydrazyl radical scavenging capacity (DPPH), vitamin E, vitamin C), and oxidative damage markers (i.e., advanced oxidation protein products (AOPPs), oxidized low-density lipoproteins (oxLDLs), malondialdehyde (MDA)). The WGPF-burger intake significantly reduced glycemia and homeostatic model assessment-based measurement of insulin resistance. Vitamin C increased and decreased during the consumption of the WGPF-burger and control-burger, respectively. The WGPF-burger intake significantly decreased AOPP and oxLDL levels. Vitamin E and MDA levels showed no significant changes. In conclusion, the consumption of beef burgers prepared with WGPF improved fasting glucose and insulin resistance, plasma antioxidant levels, and oxidative damage markers. Therefore, this functional ingredient has potential as a dietary supplement to manage chronic disease risk in humans.
C1 [Urquiaga, Ines; Troncoso, Danitza; Jose Mackenna, Maria; Urzua, Catalina; Perez, Druso; Dicenta, Sara; Maria de la Cerda, Paula; Echeverria, Guadalupe; Rigotti, Attilio] Pontificia Univ Catolica Chile, Sch Med, Ctr Mol Nutr & Chron Dis, Santiago 08330033, Chile.
   [Amigo, Ludwig; Rigotti, Attilio] Pontificia Univ Catolica Chile, Sch Med, Dept Nutr Diabet & Metab, Santiago 08330033, Chile.
   [Carlos Carreno, Juan] Agrosuper Comercializadora Alimentos Ltda, Rancagua, Chile.
C3 Pontificia Universidad Catolica de Chile; Pontificia Universidad
   Catolica de Chile
RP Urquiaga, I (corresponding author), Pontificia Univ Catolica Chile, Sch Med, Ctr Mol Nutr & Chron Dis, Santiago 08330033, Chile.
EM iurquiaga@bio.puc.cl; da.troncosos@gmail.com; josemackenna@gmail.com;
   catalina.urzua.u@gmail.com; dperezp@uc.cl; saradicenta@opalum.es;
   pdelacerda@gmail.com; ludwig@med.puc.cl; jcarreno@agrosuper.com;
   gecheverria@bio.puc.cl; arigotti@med.puc.cl
RI Echeverría, Guadalupe/GWV-3832-2022
OI Echeverria, Guadalupe/0000-0002-2915-0171; Carreno, Juan
   Carlos/0000-0002-8625-1032
FU FONDEF-CONICYT [IT14i10011]
FX This work was supported by FONDEF-CONICYT (grant #IT14i10011).
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NR 59
TC 31
Z9 32
U1 0
U2 15
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD OCT
PY 2018
VL 10
IS 10
AR 1388
DI 10.3390/nu10101388
PG 15
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA GY7UM
UT WOS:000448821300054
PM 30275350
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Lo, EM
   Rodriguez, KM
   Pastuszak, AW
   Khera, M
AF Lo, Eric M.
   Rodriguez, Katherine M.
   Pastuszak, Alexander W.
   Khera, Mohit
TI Alternatives to Testosterone Therapy: A Review
SO SEXUAL MEDICINE REVIEWS
LA English
DT Review
DE Testosterone; Aromatase Inhibitors; Selective Estrogen Receptor
   Modulator; Varicocele; Testosterone Therapy; Human Chorionic
   Gonadotropin
ID HUMAN CHORIONIC-GONADOTROPIN; OLDER MEN; ERECTILE DYSFUNCTION; ANDROGEN
   DEFICIENCY; CLOMIPHENE CITRATE; METABOLIC SYNDROME; HYPOGONADOTROPIC
   HYPOGONADISM; AROMATASE INHIBITION; TESTICULAR FUNCTION; INFERTILE MEN
AB Introduction: Although testosterone therapy (TTh) is an effective treatment for hypogonadism, recent concerns regarding its safety have been raised. In 2015, the US Food and Drug Administration issued a warning about potential cardiovascular risks resulting from TTh. Fertility preservation is another reason to search for viable alternative therapies to conventional TTh, and in this review we evaluate the literature examining these alternatives.
   Aims: To review the role and limitations of non-testosterone treatments for hypogonadism.
   Methods: A literature search was conducted using PubMed to identify relevant studies examining medical and non-medical alternatives to TTh. Search terms included hypogonadism, testosterone replacement therapy, testosterone therapy, testosterone replacement alternatives, diet and exercise and testosterone, varicocele repair and testosterone, stress reduction and testosterone, and sleep apnea and testosterone.
   Main Outcome Measures: Review of peer-reviewed literature.
   Results: Medical therapies examined include human chorionic gonadotropins, aromatase inhibitors, and selective estrogen receptor modulators. Non-drug therapies that are reviewed include lifestyle modifications including diet and exercise, improvements in sleep, decreasing stress, and varicocele repair. The high prevalence of obesity and metabolic syndrome in the United States suggests that disease modification could represent a viable treatment approach for affected men with hypogonadism.
   Conclusions: These alternatives to TTh can increase testosterone levels and should be considered before TTh. Lo EM, Rodriguez KM, Pastuszak AW, Khera M. Alternatives to Testosterone Therapy: A Review. Sex Med Rev 2018;6:106-113. Copyright (C) 2017, International Society for Sexual Medicine. Published by Elsevier Inc. All rights reserved.
C1 [Lo, Eric M.; Rodriguez, Katherine M.] Baylor Coll Med, Houston, TX 77030 USA.
   [Pastuszak, Alexander W.] Baylor Coll Med, Ctr Reprod Med, Houston, TX 77030 USA.
   [Pastuszak, Alexander W.; Khera, Mohit] Baylor Coll Med, Scott Dept Urol, Houston, TX 77030 USA.
C3 Baylor College of Medicine; Baylor College of Medicine; Baylor College
   of Medicine
RP Khera, M (corresponding author), 7200 Cambridge St, Houston, TX 77005 USA.
EM mkhera@bcm.edu
OI Pastuszak, Alexander/0000-0002-6740-8348; Lo, Eric/0000-0001-7118-0852
FU Male Reproductive Health Research Career Development Physician-Scientist
   Award [HD073917-01]; Eunice Kennedy Shriver National Institute of Child
   Health and Human Development Program
FX Dr Pastuszak is a K12 scholar supported by a Male Reproductive Health
   Research Career Development Physician-Scientist Award (grant
   HD073917-01) from the Eunice Kennedy Shriver National Institute of Child
   Health and Human Development Program.
CR [Anonymous], [No title captured]
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NR 59
TC 44
Z9 46
U1 0
U2 13
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2050-0513
EI 2050-0521
J9 SEX MED REV
JI Sex. Med. Rev.
PD JAN
PY 2018
VL 6
IS 1
BP 106
EP 113
DI 10.1016/j.sxmr.2017.09.004
PG 8
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA JN2RC
UT WOS:000496747100012
PM 29174957
DA 2025-06-11
ER

PT J
AU Saravanan, N
   Patil, MA
   Kumar, PU
   Suryanarayana, P
   Reddy, GB
AF Saravanan, Natarajan
   Patil, Madhoosudhan Ananth
   Kumar, Puthcha Uday
   Suryanarayana, Palla
   Reddy, Geereddy Bhanuprakash
TI Dietary ginger improves glucose dysregulation in a long-term high-fat
   high-fructose fed prediabetic rat model
SO INDIAN JOURNAL OF EXPERIMENTAL BIOLOGY
LA English
DT Article
DE Diet; Glucose dysregulation; Hyperinsulinemia; Hyperglycemia;
   Hypertriglyceridemia; Insulin resistance; metabolic syndrome; Type 2
   diabetes; Zingiber officinale
ID ZINGIBER-OFFICINALE ROSCOE; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   ETHANOLIC EXTRACT; HIGH-CARBOHYDRATE; SENSITIVITY; MECHANISMS;
   TOLERANCE; OBESITY; LIVER
AB The rapid increase in global diabetes burden with its associated morbidity and mortality is a major health concern for humans. Prediabetes is a condition which predispose a person not only to diabetes but also to the associated complications including morbidity even in the absaace of an apparant hyperglycemia. However, appropriate dietary intervention may not only prevent but also improve one's condition as diet is the major contributor to such metabolic disorders. Here, we investigated the effect of dietary ginger (Zingiber officinale Roscoe) on the markers of insulin resistance and pathophysiology in a diet-induced prediabetic rat model. Male Sprague-Dawley (SD) rats were fed the following diets: control (5% groundnut oil + 65 % corn starch), high fat high fructose (HFHF; 25% beef tallow + 35 % fructose) and HFHF with 3 % ginger (HFHFG) for eight months. Plasma markers of insulin resistance, lipid profile, oral glucose tolerance (OGTT; 2nd and 5th month), intraperitoneal insulin tolerance (ITT), plasma total antioxidant capacity (TAC), liver histology and pancreatic immunohistochemistry (IHC) were examined. The impaired OGTT, ITT and insulin sensitivity indices with observed hyperinsulinemia and hypertriglyceridemia suggest that HFHF feeding resulted in prediabetes in rats. HFHF feeding also decreased insulin secretion in the pancreas, increased lipid accumulation in liver and total oxidants in plasma. The effects of HFHF feeding on glucose regulation, pathophysiology of pancreas and liver; total oxidative stress were improved by ginger feeding. The present study demonstrated that long-term HFHF feeding induces prediabetes in experimental rats while dietary ginger neutralizes the HFHF induced impairment in glucose regulation, dyslipidemia, and oxidative stress.
C1 [Saravanan, Natarajan; Patil, Madhoosudhan Ananth; Suryanarayana, Palla; Reddy, Geereddy Bhanuprakash] Natl Inst Nutr, Div Biochem, Hyderabad, Andhra Pradesh, India.
   [Kumar, Puthcha Uday] Natl Inst Nutr, Div Pathol, Hyderabad, Andhra Pradesh, India.
C3 Indian Council of Medical Research (ICMR); ICMR - National Institute of
   Nutrition (NIN); Indian Council of Medical Research (ICMR); ICMR -
   National Institute of Nutrition (NIN)
RP Reddy, GB (corresponding author), Natl Inst Nutr, Div Biochem, Hyderabad, Andhra Pradesh, India.
EM geereddy@yahoo.com
RI Patil, Madhoosudan/Y-9859-2019; Reddy, G. Bhanuprakash/AAJ-3494-2020
OI Reddy, G. Bhanuprakash/0000-0003-4787-3944
FU Indian Council of Medical Research; Department of Science Technology;
   Department of Biotechnology, Government of India
FX The second author MAP is a recipient of Senior Research Fellowship from
   the Indian Council of Medical Research. This work was supported by
   grants from Department of Science & Technology and Department of
   Biotechnology, Government of India.
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NR 48
TC 15
Z9 15
U1 0
U2 15
PU NATL INST SCIENCE COMMUNICATION-NISCAIR
PI NEW DELHI
PA DR K S KRISHNAN MARG, PUSA CAMPUS, NEW DELHI 110 012, INDIA
SN 0019-5189
EI 0975-1009
J9 INDIAN J EXP BIOL
JI Indian J. Exp. Biol.
PD MAR
PY 2017
VL 55
IS 3
BP 142
EP 150
PG 9
WC Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics
GA EN2OK
UT WOS:000395849600002
PM 30184415
DA 2025-06-11
ER

PT J
AU Tarantino, G
   Finelli, C
   Colao, A
   Capone, D
   Tarantino, M
   Grimaldi, E
   Chianese, D
   Gioia, S
   Pasanisi, F
   Contaldo, F
   Scopacasa, F
   Savastano, S
AF Tarantino, Giovanni
   Finelli, Carmine
   Colao, Annamaria
   Capone, Domenico
   Tarantino, Marianna
   Grimaldi, Ernesto
   Chianese, Donato
   Gioia, Saverio
   Pasanisi, Fabrizio
   Contaldo, Franco
   Scopacasa, Francesco
   Savastano, Silvia
TI Are hepatic steatosis and carotid intima media thickness associated in
   obese patients with normal or slightly elevated
   gamma-glutamyltransferase?
SO JOURNAL OF TRANSLATIONAL MEDICINE
LA English
DT Article
DE NAFLD; Atherosclerosis; Metabolic syndrome
ID FATTY LIVER-DISEASE; ENDOPLASMIC-RETICULUM STRESS; HEAT-SHOCK PROTEINS;
   C-REACTIVE PROTEIN; INSULIN-RESISTANCE; ATHEROSCLEROSIS; INFLAMMATION;
   CHOLESTEROL; MEN
AB Background: Hepatic steatosis (HS) has been associated with obesity and metabolic syndrome (MS), conditions carrying a high risk of coronary artery disease. We aimed to determine whether HS was an independent factor of atherogenic risk beyond its association with MS and its components.
   Methods: We assessed the circulating levels of the heat shock protein-70 (HSP-70), a chaperone involved in inflammation, endoplasmic reticulum stress and apoptosis at liver and endothelial level and the gamma-glutamyl transferase activity (gamma-GT) correlating them to carotid intima-media thickness (IMT), along with lipid profile, HOMA, C-reactive protein, fibrinogen, ferritin, adiposity type as well as spleen volume in 52 obese pts with grade 1, 128 with grade 2, and 20 with grade 3 of HS evaluated by sonography.
   Results: Patients with different grade of HS demonstrated overlapping HSP-70 levels; similarly performed obese subjects regarding IMT. Using multiple regression analysis, IMT was predicted by age, visceral adiposity and by HOMA (beta = 0.50, rho < 0.0001, beta = 0.30, rho = 0.01 and beta = 0.18, rho = 0.048 respectively, while the severity of HS was predicted by visceral and subcutaneous adiposity and HOMA (beta = 0.50, rho < 0.0001 and beta = 0.27, rho = 0.001 and beta = 0.18, rho = 0.024, respectively).
   Conclusion: In our series of patients with normal or mild elevation of gamma-GT, the severity of HS does not entail higher IMT, which may be linked to MS stigmata.
C1 [Tarantino, Giovanni; Pasanisi, Fabrizio; Contaldo, Franco] Federico II Univ Med Sch Naples, Dept Clin & Expt Med, Naples, Italy.
   [Finelli, Carmine; Gioia, Saverio] Fdn Stella Maris Mediterraneo, Ctr Riferimento Reg Disturbi & Comportamenti Alim, Chiaromonte, PZ, Italy.
   [Colao, Annamaria; Savastano, Silvia] Federico II Univ Med Sch Naples, Endocrinol Sect, Dept Mol & Clin Endocrinol & Oncol, Naples, Italy.
   [Capone, Domenico] Federico II Univ Med Sch Naples, Clin Pharmacol Unit, Dept Neurosci, Naples, Italy.
   [Tarantino, Marianna] Federico II Univ Med Sch Naples, Dept Biomorphol & Funct Sci, Naples, Italy.
   [Grimaldi, Ernesto; Chianese, Donato; Scopacasa, Francesco] Federico II Univ Med Sch Naples, Dept Biochem & Med Biotechnol, Naples, Italy.
C3 University of Naples Federico II; IRCCS Fondazione Stella Maris;
   University of Naples Federico II; University of Naples Federico II;
   University of Naples Federico II; University of Naples Federico II
RP Tarantino, G (corresponding author), Federico II Univ Med Sch Naples, Dept Clin & Expt Med, Naples, Italy.
EM tarantin@unina.it
RI Colao, Annamaria/A-7671-2011; Tarantino, Giovanni/AAW-2007-2021;
   Pasanisi, Fabrizio/L-7437-2015; Savastano, Silvia/K-6546-2016
OI Pasanisi, Fabrizio/0000-0003-4224-7821; Chianese,
   Donato/0000-0003-2437-1466; Savastano, Silvia/0000-0002-3211-4307;
   Contaldo, Franco/0000-0002-3657-3922
FU Federico II University Medical School
FX This research was supported by departmental funds of Federico II
   University Medical School
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NR 41
TC 50
Z9 51
U1 0
U2 11
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1479-5876
J9 J TRANSL MED
JI J. Transl. Med.
PD MAR 16
PY 2012
VL 10
AR 50
DI 10.1186/1479-5876-10-50
PG 9
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 934BV
UT WOS:000303416200001
PM 22424154
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Huang, PS
   Wang, CS
   Yeh, CT
   Lin, KH
AF Huang, Po-Shuan
   Wang, Chia-Siu
   Yeh, Chau-Ting
   Lin, Kwang-Huei
TI Roles of Thyroid Hormone-Associated microRNAs Affecting Oxidative Stress
   in Human Hepatocellular Carcinoma
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE oxidative stress; microRNA; thyroid hormone; liver cancer
ID HEPATITIS-C VIRUS; DOXORUBICIN-INDUCED CARDIOTOXICITY; TOTAL T3 LEVEL;
   LIVER-CANCER; DNA-DAMAGE; INHIBITS PROLIFERATION; TRANSCRIPTION FACTOR;
   ANTIOXIDANT DEFENSE; TELOMERASE ACTIVITY; LIPID-PEROXIDATION
AB Oxidative stress occurs as a result of imbalance between the generation of reactive oxygen species (ROS) and antioxidant genes in cells, causing damage to lipids, proteins, and DNA. Accumulating damage of cellular components can trigger various diseases, including metabolic syndrome and cancer. Over the past few years, the physiological significance of microRNAs (miRNA) in cancer has been a focus of comprehensive research. In view of the extensive level of miRNA interference in biological processes, the roles of miRNAs in oxidative stress and their relevance in physiological processes have recently become a subject of interest. In-depth research is underway to specifically address the direct or indirect relationships of oxidative stress-induced miRNAs in liver cancer and the potential involvement of the thyroid hormone in these processes. While studies on thyroid hormone in liver cancer are abundantly documented, no conclusive information on the potential relationships among thyroid hormone, specific miRNAs, and oxidative stress in liver cancer is available. In this review, we discuss the effects of thyroid hormone on oxidative stress-related miRNAs that potentially have a positive or negative impact on liver cancer. Additionally, supporting evidence from clinical and animal experiments is provided.
C1 [Huang, Po-Shuan; Lin, Kwang-Huei] Chang Gung Univ, Dept Biochem, Coll Med, Taoyuan 33302, Taiwan.
   [Huang, Po-Shuan; Lin, Kwang-Huei] Chang Gung Univ, Dept Biomed Sci, Coll Med, Taoyuan 33302, Taiwan.
   [Wang, Chia-Siu] Chang Gung Mem Hosp, Dept Gen Surg, Chiayi 61363, Taiwan.
   [Yeh, Chau-Ting; Lin, Kwang-Huei] Chang Gung Mem Hosp, Liver Res Ctr, Taoyuan 33302, Taiwan.
   [Lin, Kwang-Huei] Chang Gung Univ Sci & Technol, Coll Human Ecol, Res Ctr Chinese Herbal Med, Taoyuan 33302, Taiwan.
C3 Chang Gung University; Chang Gung University; Chang Gung Memorial
   Hospital; Chang Gung Memorial Hospital; Chang Gung University of Science
   & Technology
RP Lin, KH (corresponding author), Chang Gung Univ, Dept Biochem, Coll Med, Taoyuan 33302, Taiwan.; Lin, KH (corresponding author), Chang Gung Univ, Dept Biomed Sci, Coll Med, Taoyuan 33302, Taiwan.; Lin, KH (corresponding author), Chang Gung Mem Hosp, Liver Res Ctr, Taoyuan 33302, Taiwan.; Lin, KH (corresponding author), Chang Gung Univ Sci & Technol, Coll Human Ecol, Res Ctr Chinese Herbal Med, Taoyuan 33302, Taiwan.
EM leo_6813@msn.com; wangcs@cgmh.org.tw; chauting@adm.cgmh.org.tw;
   khlin@mail.cgu.edu.tw
OI Lin, Kwang-Huei/0000-0002-5649-2222
FU Chang Gung Memorial Hospital, Taoyuan, Taiwan; Ministry of Science and
   Technology of the Republic of China [MOST 106-2320-B-182-031-MY3,
   106-2320-B-182-032-MY3]
FX This research was funded by grants from Chang Gung Memorial Hospital,
   Taoyuan, Taiwan (CMRPD1J0051, CMRPD1H0631 to K. H. Lin; CMRPG6F0621,
   CMRPG6F0622, CMRPG6F0623 to C. S. Wang) and from the Ministry of Science
   and Technology of the Republic of China (MOST 106-2320-B-182-031-MY3 and
   106-2320-B-182-032-MY3 to K.H. Lin). And The APC was funded by Chang
   Gung Memorial Hospital, Taoyuan, Taiwan.
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NR 191
TC 28
Z9 29
U1 0
U2 11
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD OCT 2
PY 2019
VL 20
IS 20
AR 5220
DI 10.3390/ijms20205220
PG 24
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA JQ3AZ
UT WOS:000498822800252
PM 31640265
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Tavares, VDD
   Schuch, FB
   de Sousa, GM
   Hallgren, M
   Neto, LO
   Cabral, DAR
   de Almeida, RN
   Barbosa, DC
   de Almeida, VRN
   Tinoco, H
   Lira, RA
   Hallak, JE
   Arcoverde, E
   Cuthbert, C
   Patten, S
   Galvao-Coelho, NL
AF Tavares, Vagner Deuel de O.
   Schuch, Felipe B.
   de Sousa, Geovan Menezes
   Hallgren, Mats
   Oliveira Neto, Leonidas
   Cabral, Daniel A. R.
   de Almeida, Raissa Nobrega
   Barbosa, David Cavalcante
   de Almeida, Victor Rocha Nobrega
   Tinoco, Hanna
   Lira, Rodolfo A.
   Hallak, Jaime Eduardo
   Arcoverde, Emerson
   Cuthbert, Colleen
   Patten, Scott
   Galvao-Coelho, Nicole Leite
TI Effectiveness of an affect-adjusted, supervised, multimodal, online and
   home-based exercise group protocol for major depression: A randomized
   controlled trial
SO PSYCHOLOGY OF SPORT AND EXERCISE
LA English
DT Article
DE Multimodal exercise; Cardiorespiratory fitness; Major depression;
   Randomized controlled trial
ID SHUTTLE RUN TEST; CARDIORESPIRATORY FITNESS; PHYSICAL-ACTIVITY; BIPOLAR
   DISORDER; PERCEIVED EXERTION; METABOLIC SYNDROME; PEOPLE; SCALE;
   METAANALYSIS; VALIDITY
AB This randomized controlled trial investigated the effectiveness of an affect-adjusted, supervised, multimodal, online, and home-based exercise group protocol as an adjunct therapy to antidepressants on depressive symptoms, cardiorespiratory fitness, and side effects related to antidepressants in adults with major depression (MDD, diagnosed by a clinician). Depressive symptom scales were administered by a psychiatrist and self-reported. A health-related measure (i.e., cardiorespiratory fitness), was also administered. The exercise intervention was adjusted by perceived effort and affect (pleasure and enjoyment) toward exercise and lasted 12 weeks. In total, 59 adults with MDD were divided into two groups: the exercise-group (EG; exercise + pharmacotherapy) with 26-patients (76.9 % females, mean age 28.5 years) and the control-group (CG, pharmacotherapy) with 33-patients (78.7 % females, mean age 25.6 years). The EG had a lower dropout rate (15.3 %) than CG and an increase in cardiorespiratory fitness (CRF), which was not observed in the CG. Both groups showed a decrease in self-reported depressive symptoms. However, the EG had significantly lower depressive symptom scores at t1 and t2. The EG also had higher remission rates (t1, EG: = 42.3 % and CG = 27.2 %) and remission rates (t2, EG: = 72.7 % and CG = 48.1 %) than CG, which were maintained during the four month follow-up. Side effects from anti-depressant medication were larger in the EG compared to CG. Complementing usual care for MDD with exercise resulted in better clinical outcomes and supports the use of this type of exercise protocol in the clinical management of depression.
C1 [Tavares, Vagner Deuel de O.; de Sousa, Geovan Menezes; de Almeida, Raissa Nobrega; Tinoco, Hanna; Lira, Rodolfo A.; Galvao-Coelho, Nicole Leite] Univ Fed Rio Grande do Norte, Dept Physiol & Behav, Lab Hormone Measurement, Natal, Brazil.
   [Tavares, Vagner Deuel de O.; de Sousa, Geovan Menezes; Galvao-Coelho, Nicole Leite] Univ Fed Rio Grande do Norte, Ctr Biosci, Grad Program Psychobiol, Natal, Brazil.
   [Tavares, Vagner Deuel de O.; Patten, Scott] Univ Calgary, Dept Community Hlth Sci, Calgary, AB, Canada.
   [Tavares, Vagner Deuel de O.; Cuthbert, Colleen] Univ Calgary, Fac Nursing, Calgary, AB, Canada.
   [Schuch, Felipe B.] Univ Fed Santa Maria, Dept Sports Methods & Tech, Santa Maria, Brazil.
   [Schuch, Felipe B.] Univ Fed Rio de Janeiro, Inst Psychiat, Rio De Janeiro, Brazil.
   [Schuch, Felipe B.] Univ Autonoma Chile, Inst Hlth Sci, Providencia, Chile.
   [Hallgren, Mats] Karolinska Inst, Dept Global Publ Hlth, Stockholm, Sweden.
   [Oliveira Neto, Leonidas] Univ Fed Rio Grande do Norte, Dept Phys Educ, Res Grp Biomech GEBIO, Natal, RN, Brazil.
   [Cabral, Daniel A. R.] Virginia Tech Carilion, Fralin Biomed Res Inst, Roanoke, VA USA.
   [Barbosa, David Cavalcante; de Almeida, Victor Rocha Nobrega] Univ Fed Rio Grande do Norte, Onofre Lopes Univ Hosp, Natal, Brazil.
   [Hallak, Jaime Eduardo] Univ Sao Paulo, Ribeirao Preto Med Sch, Neurosci & Behav Dept, Sao Paulo, Brazil.
   [Hallak, Jaime Eduardo; Arcoverde, Emerson; Galvao-Coelho, Nicole Leite] Natl Inst Sci & Technol Translat Med INCT TM, CNPq, CAPES, FAPESP, Brasilia, Brazil.
   [Cuthbert, Colleen] Univ Calgary, Cumming Sch Med, Dept Oncol, Calgary, AB, Canada.
   [Galvao-Coelho, Nicole Leite] Western Sydney Univ, NICM Hlth Res Inst, Westmead, NSW, Australia.
C3 Universidade Federal do Rio Grande do Norte; Universidade Federal do Rio
   Grande do Norte; University of Calgary; University of Calgary;
   Universidade Federal de Santa Maria (UFSM); Universidade Federal do Rio
   de Janeiro; Universidad Autonoma de Chile; Karolinska Institutet;
   Universidade Federal do Rio Grande do Norte; Universidade Federal do Rio
   Grande do Norte; Universidade de Sao Paulo; Coordenacao de
   Aperfeicoamento de Pessoal de Nivel Superior (CAPES); Fundacao de Amparo
   a Pesquisa do Estado de Sao Paulo (FAPESP); University of Calgary;
   Western Sydney University
RP Galvao-Coelho, NL (corresponding author), Campus Univ UFRN Lagoa Nova, BR-59072970 Natal, RN, Brazil.
EM nicole.galvao@ufrn.br
RI Schuch, Felipe/AAF-5028-2019; Hallak, Jaime/J-3547-2012; Neto,
   Leônida/AAB-1131-2021; Patten, Scott/B-4434-2011; Cabral,
   Daniel/I-6686-2018; Galvão-Coelho, Nicole/E-3439-2014; Tavares,
   Vagner/JNE-8973-2023
OI Menezes Sousa Junior, Geovan/0000-0002-8674-5067; Cavalcante Barbosa,
   David/0009-0005-3947-577X; Hallak, Jaime/0000-0002-8784-0189
FU Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior - Brasil
   (CAPES) [001]; CAPES [Proc. 88887.597821/2021-00]
FX This study was financed in part by the Coordenacao de Aperfeicoamento de
   Pessoal de Nivel Superior - Brasil (CAPES) - Finance Code 001. VDOT and
   GMS was supported by CAPES (Proc. 88887.597821/2021-00).
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NR 65
TC 4
Z9 4
U1 8
U2 11
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1469-0292
EI 1878-5476
J9 PSYCHOL SPORT EXERC
JI Psychol. Sport Exerc.
PD JAN
PY 2025
VL 76
AR 102729
DI 10.1016/j.psychsport.2024.102729
EA SEP 2024
PG 11
WC Hospitality, Leisure, Sport & Tourism; Psychology, Applied; Psychology;
   Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Social Sciences - Other Topics; Psychology; Sport Sciences
GA H7P2L
UT WOS:001325319200001
PM 39299665
DA 2025-06-11
ER

PT J
AU Busquets-Cortés, C
   Capó, X
   Argelich, E
   Ferrer, MD
   Mateos, D
   Bouzas, C
   Abbate, M
   Tur, JA
   Sureda, A
   Pons, A
AF Busquets-Cortes, Carla
   Capo, Xavier
   Argelich, Emma
   Ferrer, Miguel D.
   Mateos, David
   Bouzas, Cristina
   Abbate, Manuela
   Tur, Josep A.
   Sureda, Antoni
   Pons, Antoni
TI Effects of Millimolar Steady-State Hydrogen Peroxide Exposure on
   Inflammatory and Redox Gene Expression in Immune Cells from Humans with
   Metabolic Syndrome
SO NUTRIENTS
LA English
DT Article
DE gene expression; glucose oxidase; hydrogen peroxide; inflammation;
   mitochondrial biogenesis; neutrophils; PBMCs; ROS
ID ANTIOXIDANT ENZYME-ACTIVITIES; NUCLEAR RESPIRATORY FACTOR-2; OXYGEN
   SPECIES ROS; OXIDATIVE STRESS; SKELETAL-MUSCLE; DIET SUPPLEMENTATION;
   TNF-ALPHA; EXERCISE; PROTEIN; OBESITY
AB Reactive oxygen species (ROS) such as hydrogen peroxide (H2O2) can exert opposed effects depending on the dosage: low levels can be involved in signalling and adaptive processes, while higher levels can exert deleterious effects in cells and tissues. Our aim was to emulate a chronic ex vivo oxidative stress situation through a 2 h exposure of immune cells to sustained H2O2 produced by glucose oxidase (GOX), at high or low production rate, in order to determine dissimilar responses of peripheral blood mononuclear cells (PBMCs) and neutrophils on ROS and cytokine production, and mitochondrial dynamics-related proteins, pro/anti-inflammatory and anti-oxidant gene expression. Immune cells were obtained from subjects with metabolic syndrome. H2O2 at low concentrations can trigger a transient anti-inflammatory adiponectin secretion and reduced gene expression of toll-like receptors (TLRs) in PBMCs but may act as a stimulator of proinflammatory genes (IL6, IL8) and mitochondrial dynamics-related proteins (Mtf2, NRF2, Tfam). H2O2 at a high concentration enhances the expression of pro-inflammatory genes (TLR2 and IL1) and diminishes the expression of mitochondrial dynamics-related proteins (Mtf1, Tfam) and antioxidant enzymes (Cu/Zn SOD) in PBMCs. The GOX treatments produce dissimilar changes in immune cells: Neutrophils were more resistant to H2O2 effects and exhibited a more constant response in terms of gene expression than PBMCs. We observe emerging roles of H2O2 in mitochondrial dynamics and redox and inflammation processes in immune cells.
C1 [Busquets-Cortes, Carla; Capo, Xavier; Argelich, Emma; Ferrer, Miguel D.; Mateos, David; Bouzas, Cristina; Abbate, Manuela; Tur, Josep A.; Sureda, Antoni; Pons, Antoni] Univ Balearic Isl, Dept Fundamental Biol & Hlth Sci, Res Grp Community Nutr & Oxidat Stress, Sci Lab Phys Act, Palma De Mallorca 07122, Spain.
   [Tur, Josep A.; Sureda, Antoni; Pons, Antoni] Univ Balearic Isl, Inst Salud Carlos III ISCIII, CIBER Fisiopatol Obesidad Nutr CB12 03 30038, CIBEROBN, Palma De Mallorca 07122, Spain.
C3 Universitat de les Illes Balears; CIBER - Centro de Investigacion
   Biomedica en Red; CIBEROBN; Universitat de les Illes Balears
RP Pons, A (corresponding author), Univ Balearic Isl, Dept Fundamental Biol & Hlth Sci, Res Grp Community Nutr & Oxidat Stress, Sci Lab Phys Act, Palma De Mallorca 07122, Spain.; Pons, A (corresponding author), Univ Balearic Isl, Inst Salud Carlos III ISCIII, CIBER Fisiopatol Obesidad Nutr CB12 03 30038, CIBEROBN, Palma De Mallorca 07122, Spain.
EM carla_busquets@hotmail.com; xaviercapofiol@hotmail.com;
   eargelich15@gmail.com; miguel-david.ferrer@uib.es;
   david-mateos@hotmail.es; cristinabouvel@gmail.com;
   manuela.abbate@uib.es; pep.tur@uib.es; antoni.sureda@uib.es;
   antonipons@uib.es
RI Capò, Xavier/AAL-4246-2020; Tur, Josep/AAE-5748-2020; Mateos,
   David/N-7366-2018; Reynés, Miguel/J-4206-2019; Bouzas,
   Cristina/AAE-2069-2019; Sureda, Antoni/N-9588-2019; Abbate,
   Manuela/HCI-8844-2022; Pons, Antoni/L-4844-2014; Tur, Josep/F-5576-2014
OI Abbate, Manuela/0000-0001-9905-2414; Pons, Antoni/0000-0003-2447-3868;
   Tur, Josep/0000-0002-6940-0761; Bouzas Velasco,
   Cristina/0000-0002-1407-8461; Capo Fiol, Xavier/0000-0002-3499-5494; ,
   Antoni/0000-0001-8656-6838; Ferrer, Miguel D./0000-0003-1924-7727
FU official funding agency for biomedical research of the Spanish
   government, Institute of Health Carlos III (ISCIII) through the Fondo de
   Investigacion para la Salud (FIS) - European Regional Development Fund
   [14/00636, 17/01827, Red Predimed-RETIC RD06/0045/1004, CIBEROBN
   CB12/03/30038]; EU Cost ACTION [CA16112]; Balearic Islands Gov.
   [35/2011, AAEE01/2017, AAEE26/2017]
FX The PREDIMED-Plus trial was supported by the official funding agency for
   biomedical research of the Spanish government, Institute of Health
   Carlos III (ISCIII) through the Fondo de Investigacion para la Salud
   (FIS), which is co-funded by the European Regional Development Fund
   (Projects 14/00636 and 17/01827, Red Predimed-RETIC RD06/0045/1004, and
   CIBEROBN CB12/03/30038), Grant of support to research groups no.
   35/2011, AAEE01/2017, and AAEE26/2017 (Balearic Islands Gov.), and EU
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NR 87
TC 18
Z9 19
U1 0
U2 7
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 2072-6643
J9 NUTRIENTS
JI Nutrients
PD DEC
PY 2018
VL 10
IS 12
AR 1920
DI 10.3390/nu10121920
PG 18
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA HG6EG
UT WOS:000455073200101
PM 30563042
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Razavi, A
   Baghshani, MR
   Rahsepar, AA
   Ardabili, HM
   Andalibi, MSS
   Parizadeh, SMR
   Tavallaie, S
   Mousavi, S
   Ghayour-Mobarhan, M
   Ferns, G
AF Razavi, Akramosadat
   Baghshani, Mohammad Reza
   Rahsepar, Amir Ali
   Ardabili, Hossein Mohaddes
   Andalibi, Mohammad Sobhan Sheikh
   Parizadeh, Seyyed Mohammad Reza
   Tavallaie, Shima
   Mousavi, Somayeh
   Ghayour-Mobarhan, Majid
   Ferns, Gordon
TI Association between C-reactive protein, pro-oxidant-antioxidant balance
   and traditional cardiovascular risk factors in an Iranian population
SO ANNALS OF CLINICAL BIOCHEMISTRY
LA English
DT Article
ID CORONARY-ARTERY-DISEASE; PERIPHERAL POLYMORPHONUCLEAR LEUKOCYTES;
   AMERICAN-HEART-ASSOCIATION; INCREASED OXIDATIVE STRESS; URIC-ACID;
   PHYSICAL-ACTIVITY; ENDOTHELIAL DYSFUNCTION; INFLAMMATORY MARKERS;
   METABOLIC SYNDROME; XANTHINE-OXIDASE
AB Background: Inflammatory states are known to cause an imbalance in the redox status. We aimed to study the possible associations between pro-oxidant-antioxidant balance (PAB) and serum high-sensitive C-reactive protein (hs-CRP) concentrations and traditional cardiovascular disease (CVD) risk factors in an unselected Iranian population and in groups of individuals with specific disease.
   Methods: The study was conducted among an unselected population of 758 male subjects. Biochemical markers, including hs-CRP and PAB values, were measured.
   Results: Serum hs-CRP concentrations were positively associated with serum PAB values (r = 0.260, P <= 0.001). Univariate analysis showed that PAB values were statistically higher in individuals who were obese or smokers compared with non-obese and non-smokers individuals (P < 0.01). While serum hs-CRP concentrations were significantly higher in older subjects, subjects with obesity, diabetes mellitus, metabolic syndrome, central obesity, hypertriglyceridaemia, higher low-density lipoprotein cholesterol concentrations, positive history of CVD and lower physical activity than subjects without these risk factors (P < 0.05). Comparing hs-CRP and PAB values in different CVD risk score subgroups showed a significant incremental rise in both parameters as CVD risk score increased (P < 0.05). Using multiple linear regression analysis we found a strong association between PAB values and hs-CRP concentrations.
   Conclusions: This study showed that among Iranian subjects, the inflammatory marker, hs-CRP, was strongly and positively associated with a marker of oxidative stress and also with several traditional risk factors of CVD. Moreover, the impact of traditional cardiovascular risk factors on hs-CRP concentrations and PAB values differed.
C1 [Razavi, Akramosadat; Baghshani, Mohammad Reza; Rahsepar, Amir Ali; Ardabili, Hossein Mohaddes; Andalibi, Mohammad Sobhan Sheikh; Parizadeh, Seyyed Mohammad Reza; Tavallaie, Shima; Mousavi, Somayeh; Ghayour-Mobarhan, Majid] Mashhad Univ Med Sci, Fac Med, Biochem Nutr Res Ctr, Mashhad 9196773117, Iran.
   [Rahsepar, Amir Ali; Ghayour-Mobarhan, Majid] Mashhad Univ Med Sci, Fac Med, Cardiovasc Res Ctr, Mashhad 9919991766, Iran.
   [Ferns, Gordon] Keele Univ, Inst Sci & Technol Med, Stoke On Trent ST4 7QB, Staffs, England.
C3 Mashhad University of Medical Sciences; Mashhad University of Medical
   Sciences; Keele University
RP Ghayour-Mobarhan, M (corresponding author), Mashhad Univ Med Sci, Fac Med, Cardiovasc Res Ctr, Mashhad 9919991766, Iran.
EM ghayourm@mums.ac.ir
RI Ghayour-Mobarhan, Majid/AAY-5963-2020; Sheikh Andalibi,
   Mohammadsobhan/N-4411-2015
OI /0000-0002-6228-4673; Sheikh Andalibi,
   Mohammadsobhan/0000-0002-4895-1214
FU Mashhad University of Medical Science (MUMS), Iran
FX This work was supported by Mashhad University of Medical Science (MUMS),
   Iran.
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NR 57
TC 20
Z9 22
U1 0
U2 3
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0004-5632
EI 1758-1001
J9 ANN CLIN BIOCHEM
JI Ann. Clin. Biochem.
PD MAR
PY 2013
VL 50
IS 2
BP 115
EP 121
DI 10.1258/acb.2012.012104
PG 7
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA 150MT
UT WOS:000319395700004
PM 23440541
OA Bronze
DA 2025-06-11
ER

PT J
AU Auclair, N
   Sané, AT
   Delvin, E
   Spahis, S
   Levy, E
AF Auclair, Nickolas
   Sane, Alain T.
   Delvin, Edgard
   Spahis, Schohraya
   Levy, Emile
TI Phospholipase D As a Potential Modulator of Metabolic Syndrome: Impact
   of Functional Foods
SO ANTIOXIDANTS & REDOX SIGNALING
LA English
DT Article
DE oxidative stress; inflammation; insulin resistance; dyslipidemia;
   metabolic pathway; bioactive nutrients
ID PROTEIN-KINASE-C; NF-KAPPA-B; POLYUNSATURATED FATTY-ACIDS;
   ADP-RIBOSYLATION FACTOR-1; PHOSPHATIDIC-ACID; D ACTIVATION;
   ENDOTHELIAL-CELLS; D INHIBITORS; GLUCOSE-TRANSPORT; SIGNALING PATHWAY
AB Significance:Cardiometabolic disorders (CMD) are composed of a plethora of metabolic dysfunctions such as dyslipidemia, nonalcoholic fatty liver disease, insulin resistance, and hypertension. The development of these disorders is highly linked to inflammation and oxidative stress (OxS), two metabolic states closely related to physiological and pathological conditions. Given the drastically rising CMD prevalence, the discovery of new therapeutic targets/novel nutritional approaches is of utmost importance. Recent Advances:The tremendous progress in methods/technologies and animal modeling has allowed the clarification of phospholipase D (PLD) critical roles in multiple cellular processes, whether directly or indirectlyviaphosphatidic acid, the lipid product mediating signaling functions. In view of its multiple features and implications in various diseases, PLD has emerged as a drug target. Critical Issues:Although insulin stimulates PLD activity and, in turn, PLD regulates insulin signaling, the impact of the two important PLD isoforms on the metabolic syndrome components remains vague. Therefore, after outlining PLD1/PLD2 characteristics and functions, their role in inflammation, OxS, and CMD has been analyzed and critically reported in the present exhaustive review. The influence of functional foods and nutrients in the regulation of PLD has also been examined. Future Directions:Available evidence supports the implication of PLD in CMD, but only few studies emphasize its mechanisms of action and specific regulation by nutraceutical compounds. Therefore, additional investigations are first needed to clarify the functional role of nutraceutics and, second, to elucidate whether targeting PLDs with food compounds represents an appropriate therapeutic strategy to treat CMD.
C1 [Auclair, Nickolas; Sane, Alain T.; Delvin, Edgard; Spahis, Schohraya; Levy, Emile] Univ Montreal, Res Ctr, CHU St Justine, 3175 Ste Catherine Rd 4-17-005, Montreal, PQ H3T 1C5, Canada.
   [Auclair, Nickolas; Levy, Emile] Univ Montreal, Dept Pharmacol & Physiol, Montreal, PQ, Canada.
   [Spahis, Schohraya; Levy, Emile] Univ Montreal, Dept Nutr, Montreal, PQ, Canada.
C3 Universite de Montreal; Centre Hospitalier Universitaire Sainte-Justine;
   Universite de Montreal; Universite de Montreal
RP Levy, E (corresponding author), Univ Montreal, Res Ctr, CHU St Justine, 3175 Ste Catherine Rd 4-17-005, Montreal, PQ H3T 1C5, Canada.
EM emile.levy@recherche-ste-justine.qc.ca
OI Spahis, Schohraya/0000-0003-4130-4994
FU Canadian Institutes of Health Research Grants [PJT 153113]; J.A. DeSeve
   Research Chair in Nutrition
FX This study was supported by the Canadian Institutes of Health Research
   Grants (PJT 153113) and the J.A. DeSeve Research Chair in Nutrition.
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NR 269
TC 4
Z9 5
U1 0
U2 16
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1523-0864
EI 1557-7716
J9 ANTIOXID REDOX SIGN
JI Antioxid. Redox Signal.
PD JAN 20
PY 2021
VL 34
IS 3
BP 252
EP 278
DI 10.1089/ars.2020.8081
EA JUL 2020
PG 27
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA PP0DR
UT WOS:000556041700001
PM 32586106
DA 2025-06-11
ER

PT J
AU Wu, JP
   Liao, W
   Udenigwe, CC
AF Wu, Jianping
   Liao, Wang
   Udenigwe, Chibuike C.
TI Revisiting the mechanisms of ACE inhibitory peptides from food proteins
SO TRENDS IN FOOD SCIENCE & TECHNOLOGY
LA English
DT Article; Proceedings Paper
CT 1st International Conference on Food Bioactives and Health (FBHC)
CY SEP 13-15, 2016
CL Norwich, ENGLAND
SP Quadrum Inst Bioscience
DE Bioactive peptides; Antihypertension; ACE inhibition; ACE2; Metabolic
   syndrome; Cardiovascular disease; Endothelial function; Vascular
   oxidation; Inflammation
ID ANGIOTENSIN-CONVERTING ENZYME; ENDOTHELIAL DYSFUNCTION; BLOOD-PRESSURE;
   OXIDATIVE STRESS; ANTIHYPERTENSIVE PEPTIDES; BIOACTIVE PEPTIDES;
   VASCULAR FUNCTION; ALPHA-LACTORPHIN; PROGNOSTIC VALUE; MILK
AB Background: Angiotensin converting enzyme (ACE) is a key enzyme in the renin angiotensin system (RAS) responsible for conversion of angiotensin (Ang) I into Ang II, a vasoconstrictor leading to elevated blood pressure. ACE inhibitory (ACEi) peptides derived from food proteins have shown potential in the prevention and management of hypertension. Although most ACEi peptides were characterized based on in vitro ACEi activity, a relationship between ACE inhibition and physiological antihypertensive effect is not apparent, indicating the involvement of other mechanisms of action.
   Scope and approach: This paper focuses on emerging antihypertensive mechanisms of ACEi peptides. As an alternate arm of the classic RAS, ACE2 cleaves Ang II into Ang (1-7) and thus counterbalances the harmful effects of Ang II. Endothelial dysfunction is now recognized as an early feature in the pathophysiology of metabolic syndrome and cardiovascular disorders including hypertension; endothelial dysfunction, vascular oxidative stress and inflammation are interplayed. Future perspectives on mechanistic study of ACEi peptides are forecasted.
   Key findings and conclusions: Apart from classic ACE inhibition, emerging evidence suggests that food peptides can exert antihypertensive activity through upregulation of ACE2 (an ACE homologue that counterbalances the detrimental effect of elevated ACE), improvement of endothelial function, as well as reduced vascular oxidation and inflammation. Future research is expected to look into the effects of bioaccessibility, bioavailability, stability and reactivity of the peptides with food and gut matrices, as well as the gut microbiota, on blood pressure reduction. (C) 2017 Elsevier Ltd. All rights reserved.
C1 [Wu, Jianping] Zhejiang Univ, Coll Biosyst Engn & Food Sci, ZJU UA Joint Lab Mol Nutr & Bioact Peptides, 865 Yuhangtang Rd, Hangzhou 310058, Zhejiang, Peoples R China.
   [Wu, Jianping; Liao, Wang] Univ Alberta, Dept Agr Food & Nutr Sci, 4-10 Ag For Bldg, Edmonton, AB T6G 2P5, Canada.
   [Udenigwe, Chibuike C.] Univ Ottawa, Fac Hlth Sci, Sch Nutr Sci, 451 Smyth Rd, Ottawa, ON K1H 8M5, Canada.
C3 Zhejiang University; University of Alberta; University of Ottawa
RP Wu, JP (corresponding author), Univ Alberta, Dept Agr Food & Nutr Sci, 4-10 Ag For Bldg, Edmonton, AB T6G 2P5, Canada.; Udenigwe, CC (corresponding author), Univ Ottawa, Fac Hlth Sci, Sch Nutr Sci, 451 Smyth Rd, Ottawa, ON K1H 8M5, Canada.
EM jwu3@ualberta.ca; cudenigw@uottawa.ca
RI Wu, Jianping/H-9150-2012; Udenigwe, Chibuike/AAM-8650-2020
OI Liao, Wang/0000-0001-8319-2199; Udenigwe, Chibuike/0000-0001-8802-7707
FU Natural Sciences and Engineering Research Council of Canada (NSERC)
FX Our research programs are supported by the Natural Sciences and
   Engineering Research Council of Canada (NSERC) through Individual
   Discovery Grants to CCU and JW.
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NR 73
TC 142
Z9 154
U1 7
U2 110
PU ELSEVIER SCIENCE LONDON
PI LONDON
PA 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND
SN 0924-2244
EI 1879-3053
J9 TRENDS FOOD SCI TECH
JI Trends Food Sci. Technol.
PD NOV
PY 2017
VL 69
SI SI
BP 214
EP 219
DI 10.1016/j.tifs.2017.07.011
PN B
PG 6
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Food Science & Technology
GA FN1TN
UT WOS:000415774200004
DA 2025-06-11
ER

PT J
AU Spahis, S
   Borys, JM
   Levy, E
AF Spahis, Schohraya
   Borys, Jean-Michel
   Levy, Emile
TI Metabolic Syndrome as a Multifaceted Risk Factor for Oxidative Stress
SO ANTIOXIDANTS & REDOX SIGNALING
LA English
DT Review
DE reactive oxygen species; mitochondria; obesity; dyslipidemia; insulin
   resistance; hypertension; cardiovascular disease
ID LOW-DENSITY-LIPOPROTEIN; FATTY-ACID OXIDATION; INDUCED
   INSULIN-RESISTANCE; OXYGEN SPECIES PRODUCTION; SKELETAL-MUSCLE;
   MITOCHONDRIAL DYSFUNCTION; ADIPOSE-TISSUE; NITRIC-OXIDE;
   CARDIOVASCULAR-DISEASE; ENDOTHELIAL-CELLS
AB Significance: Metabolic syndrome (MetS) is associated with a greater risk of diabetes and cardiovascular diseases. It is estimated that this multifactorial condition affects 20%-30% of the world's population. A detailed understanding of MetS mechanisms is crucial for the development of effective prevention strategies and adequate intervention tools that could curb its increasing prevalence and limit its comorbidities, particularly in younger age groups. With advances in basic redox biology, oxidative stress (OxS) involvement in the complex pathophysiology of MetS has become widely accepted. Nevertheless, its clear association with and causative effects on MetS require further elucidation.
   Recent Advances: Although a better understanding of the causes, risks, and effects of MetS is essential, studies suggest that oxidant/antioxidant imbalance is a key contributor to this condition. OxS is now understood to be a major underlying mechanism for mitochondrial dysfunction, ectopic lipid accumulation, and gut microbiota impairment.
   Critical Issues: Further studies, particularly in the field of translational research, are clearly required to understand and control the production of reactive oxygen species (ROS) levels, especially in the mitochondria, since the various therapeutic trials conducted to date have not targeted this major ROS-generating system, aimed to delay MetS onset, or prevent its progression.
   Future Directions: Multiple relevant markers need to be identified to clarify the role of ROS in the etiology of MetS. Future clinical trials should provide important proof of concept for the effectiveness of antioxidants as useful therapeutic approaches to simultaneously counteract mitochondrial OxS, alleviate MetS symptoms, and prevent complications. Antioxid. Redox Signal. 26, 445-461.
C1 [Spahis, Schohraya; Levy, Emile] Ste Justine MUHC, Res Ctr, Montreal, PQ, Canada.
   [Spahis, Schohraya; Levy, Emile] Univ Montreal, Dept Nutr, Montreal, PQ, Canada.
   [Borys, Jean-Michel; Levy, Emile] EPODE Int Network, Paris, France.
C3 Universite de Montreal
RP Levy, E (corresponding author), Univ Montreal, CHU Sainte Justine, Dept Nutr, GI Nutr Unit, 3175 Cote Ste Catherine, Montreal, PQ H3T 1C5, Canada.
EM emile.levy@recherche-ste-justine.qc.ca
FU JA deSeve Research Chair in nutrition; FRQS doctoral Scholarship Award
FX The current work was supported by research grants from the JA deSeve
   Research Chair in nutrition (E.L.) and FRQS doctoral Scholarship Award
   (S.S.). The authors thank D. StCyr-Huot for her technical assistance.
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NR 223
TC 98
Z9 103
U1 0
U2 27
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1523-0864
EI 1557-7716
J9 ANTIOXID REDOX SIGN
JI Antioxid. Redox Signal.
PD MAR
PY 2017
VL 26
IS 9
BP 445
EP 461
DI 10.1089/ars.2016.6756
PG 17
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA EN8DZ
UT WOS:000396232400003
PM 27302002
DA 2025-06-11
ER

PT J
AU Knight, ET
   Liu, J
   Seymour, GJ
   Faggion, CM
   Cullinan, MP
AF Knight, Ellie T.
   Liu, Jenny
   Seymour, Gregory J.
   Faggion, Clovis M., Jr.
   Cullinan, Mary P.
TI Risk factors that may modify the innate and adaptive immune responses in
   periodontal diseases
SO PERIODONTOLOGY 2000
LA English
DT Review
ID BONE-MINERAL DENSITY; SUBANTIMICROBIAL DOSE DOXYCYCLINE; TYPE-2
   DIABETES-MELLITUS; TUMOR-NECROSIS-FACTOR; NECROTIZING ULCERATIVE
   GINGIVITIS; IMPAIRED GLUCOSE-TOLERANCE; CHEMICAL PLAQUE CONTROL; SEX
   STEROID-HORMONES; CIGARETTE-SMOKING; METABOLIC SYNDROME
AB Plaque-induced periodontal diseases occur in response to the accumulation of dental plaque. Disease manifestation and progression is determined by the nature of the immune response to the bacterial complexes in plaque. In general, predisposing factors for these periodontal diseases can be defined as those factors which retain or hinder the removal of plaque and, depending upon the nature of the immune response to this plaque, the disease will either remain stable and not progress or it may progress and result in chronic periodontitis. In contrast, modifying factors can be defined as those factors that alter the nature or course of the inflammatory lesion. These factors do not cause the disease but rather modify the chronic inflammatory response, which, in turn, is determined by the nature of the innate and adaptive immune responses and the local cytokine and inflammatory mediator networks. Chronic inflammation is characterized by vascular, cellular and repair responses within the tissues. This paper will focus on how common modifying factors, such as smoking, stress, hormonal changes, diabetes, metabolic syndrome and HIV/AIDS, influence each of these responses, together with treatment implications. As treatment planning in periodontics requires an understanding of the etiology and pathogenesis of the disease, it is important for all modifying factors to be taken into account. For some of these, such as smoking, stress and diabetic control, supportive health behavior advice within the dental setting should be an integral component for overall patient management.
C1 [Knight, Ellie T.] Univ Otago, Fac Dent, Dept Oral Sci, Dunedin, New Zealand.
   [Seymour, Gregory J.] Univ Otago, Sir John Walsh Res Inst, Dunedin, New Zealand.
   [Faggion, Clovis M., Jr.] Univ Munster, Dept Periodontol & Operat Dent, D-48149 Munster, Germany.
   [Cullinan, Mary P.] Univ Otago, Sir John Walsh Res Inst, Dunedin, New Zealand.
C3 University of Otago; University of Otago; University of Munster;
   University of Otago
RP Knight, ET (corresponding author), Univ Otago, Fac Dent, Dept Oral Sci, Dunedin, New Zealand.
RI Seymour, Gregory/L-4482-2019; Faggion, Clóvis/V-1987-2019
OI Seymour, Gregory/0000-0001-7595-5651; Cullinan, Mary/0000-0002-0423-1581
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NR 430
TC 103
Z9 127
U1 1
U2 69
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0906-6713
EI 1600-0757
J9 PERIODONTOL 2000
JI Periodontol. 2000
PD JUN
PY 2016
VL 71
IS 1
BP 22
EP 51
DI 10.1111/prd.12110
PG 30
WC Dentistry, Oral Surgery & Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dentistry, Oral Surgery & Medicine
GA DJ0XU
UT WOS:000373928500003
PM 27045429
DA 2025-06-11
ER

PT J
AU Sharkey, D
   Symonds, ME
   Budge, H
AF Sharkey, Don
   Symonds, Michael E.
   Budge, Helen
TI Adipose Tissue Inflammation: Developmental Ontogeny and Consequences of
   Gestational Nutrient Restriction in Offspring
SO ENDOCRINOLOGY
LA English
DT Article
ID ENDOPLASMIC-RETICULUM STRESS; INSULIN-RESISTANCE; KAPPA-B; NUTRITIONAL
   MANIPULATION; MATERNAL UNDERNUTRITION; UNCOUPLING PROTEIN-2; METABOLIC
   SYNDROME; PRENATAL EXPOSURE; JUVENILE OBESITY; UP-REGULATION
AB Increasing adiposity predisposes to the development of the metabolic syndrome, in part, through adipose tissue dysregulation and inflammation. In addition, offspring nutrient-restricted (NR) in utero can exhibit an increased risk of early-onset insulin resistance and obesity, although the mechanisms remain unclear. We aimed to: 1) define adipose tissue ontogeny of key proinflammatory and endoplasmic reticulum stress gene expression from late fetal to early adult life and 2) examine the impact on these genes in gestational nutrient restriction. Pregnant sheep were fed 100% (control) or 50% (NR) of their nutritional requirements between early to mid (28-80 d, term similar to 147 d) or late (110-147 d) gestation. In control offspring, toll-like receptor 4 (TLR4), and the macrophage marker CD68, peaked at 30 d of life before declining. IL-18 peaked at 6 months of age, whereas the endoplasmic reticulum chaperone glucose-regulated protein 78 peaked at birth and subsequently declined through postnatal life. TLR4 and CD68 positively correlated with relative adipose tissue mass and with each other. Early to midgestational NR offspring had decreased abundance of IL-18 at 6 months of age. In late gestational NR offspring, CD68 was significantly lower at birth, a pattern that reversed in juvenile offspring, coupled with increased TLR4 abundance. In conclusion, the in utero nutritional environment can alter the adipose tissue inflammatory profile in offspring. This may contribute to the increased risk of insulin resistance or obesity, dependent on the timing of nutrient restriction. Establishing the optimal maternal diet during pregnancy could reduce the burden of later adult disease in the offspring. (Endocrinology 150: 3913-3920, 2009)
C1 [Sharkey, Don; Symonds, Michael E.; Budge, Helen] Univ Nottingham, Inst Clin Res, Ctr Reprod & Early Life, Nottingham NG7 2UH, England.
C3 University of Nottingham
RP Symonds, ME (corresponding author), Univ Nottingham Hosp, Div Child Hlth, Sch Clin Sci, E Floor,East Block,Derby Rd, Nottingham NG7 2UH, England.
EM michael.symonds@nottingham.ac.uk
OI Symonds, Michael/0000-0001-9649-8963; Sharkey, Don/0000-0002-4989-8697
FU British Heart Foundation Clinical Fellowship [FS/05/098/19942]; European
   Union [FOOD-CT-2005-007036]
FX This work was supported by British Heart Foundation Clinical Fellowship
   FS/05/098/19942 (to D.S.) and the European Union Sixth Framework for
   Research and Technical Development of the European Community, the Early
   Nutrition Programming Project (FOOD-CT-2005-007036).
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NR 46
TC 24
Z9 25
U1 0
U2 3
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0013-7227
EI 1945-7170
J9 ENDOCRINOLOGY
JI Endocrinology
PD AUG
PY 2009
VL 150
IS 8
BP 3913
EP 3920
DI 10.1210/en.2008-1784
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 472UR
UT WOS:000268158400058
PM 19423760
OA Bronze
DA 2025-06-11
ER

PT J
AU Real-Hohn, A
   Navegantes, C
   Ramos, K
   Ramos, D
   Cahuê, B
   Galina, A
   Salerno, VP
AF Real-Hohn, Antonio
   Navegantes, Clarice
   Ramos, Katia
   Ramos-Filho, Dionisio
   Cahue, Bio
   Galina, Antonio
   Salerno, Veronica P.
TI The synergism of high-intensity intermittent exercise and
   every-other-day intermittent fasting regimen on energy metabolism
   adaptations includes hexokinase activity and mitochondrial efficiency
SO PLOS ONE
LA English
DT Article
ID RAT SKELETAL-MUSCLE; GLUCOSE-TRANSPORTER; INSULIN SENSITIVITY;
   PHYSICAL-ACTIVITY; OXIDATIVE STRESS; PROTEIN; PHOSPHORYLATION;
   HYPERGLYCEMIA; EXPRESSION; INTERVAL
AB Visceral lipid accumulation, organ hypertrophy and a reduction in skeletal muscle strength are all signs associated with the severity of obesity-related disease. Intermittent fasting (IF) and high-intensity intermittent exercise (HIIE) are natural strategies that, individually, can prevent and help treat obesity along with metabolic syndrome and its associated diseases. However, the combinatorial effect of IF and HIIE on energetic metabolism is currently not well understood. We hypothesized that their combination could have a potential for more than strictly additive benefits. Here, we show that two months of every-other-day intermittent fasting regimen combined with a high-intensity intermittent exercise protocol (IF/HIIE) produced a synergistic effect, enhancing physical endurance (vs. control, HIIE and IF) and optimizing metabolic pathways of energy production in male Wistar rats. The IF/HIIE group presented enhanced glucose tolerance (vs. control, HIIE and IF), lower levels of plasma insulin (vs. control and HIIE), and a global activation of low Km hexokinases in liver (vs. control, HIIE and IF), heart (vs. control and HIIE) and skeletal muscle (vs. control, HIIE and IF). The IF/HIIE synergism, rather than a simply additive effect, is evidenced by increase in muscle mass and cross-section area, activation of the FoF1 ATP synthase, and the gain of characteristics suggestive of augmented mitochondrial mass and efficiency observed in this group. Finally, important reductions in plasma oxidative stress markers were present preferentially in IF/HIIE group. These findings provide new insights for the implementation of non-pharmaceutical strategies to prevent/treat metabolic syndrome and associated diseases.
C1 [Real-Hohn, Antonio] Med Univ Vienna, Max F Perutz Labs, Vienna, Austria.
   [Navegantes, Clarice; Ramos, Katia; Cahue, Bio; Salerno, Veronica P.] Univ Fed Rio de Janeiro, Sch Phys Educ & Sports, Biosci Dept, Lab Exercise Biochem & Mol Motors, Rio De Janeiro, Brazil.
   [Ramos-Filho, Dionisio; Galina, Antonio] Univ Fed Rio de Janeiro, Inst Med Biochem Leopoldo de Meis, Lab Bioenerget & Mitochondrial Physiol, Rio De Janeiro, Brazil.
C3 Medical University of Vienna; University of Vienna; Vienna Biocenter
   (VBC); Max F. Perutz Laboratories (MFPL); Universidade Federal do Rio de
   Janeiro; Universidade Federal do Rio de Janeiro
RP Real-Hohn, A (corresponding author), Med Univ Vienna, Max F Perutz Labs, Vienna, Austria.; Salerno, VP (corresponding author), Univ Fed Rio de Janeiro, Sch Phys Educ & Sports, Biosci Dept, Lab Exercise Biochem & Mol Motors, Rio De Janeiro, Brazil.
EM antonio.hohn@univie.ac.at; vpsalerno@yahoo.com.br
RI Salerno, Verônica/AAD-1137-2019; Ramos-Filho, Dionizio/A-3687-2010;
   Galina, Antonio/A-9292-2008; Real-Hohn, Antonio/AAS-3935-2020; Salerno,
   Veronica/F-2678-2012
OI Mendes Ramos Filho, Dionizio/0000-0003-3625-2958; Real-Hohn,
   Antonio/0000-0003-0334-2877; Galina, Antonio/0000-0003-2862-8820;
   Salerno, Veronica/0000-0002-4344-6710; Cahue, Fabio/0000-0003-2273-8893
FU Fundacao de Amparo a Pesquisa do Estado do Rio de Janeiro (FAPERJ);
   Conselho Nacional de Desenvolvimento Cienti fico e Tecnologico (CNPq)
FX This work was supported by the Fundacao de Amparo a Pesquisa do Estado
   do Rio de Janeiro (FAPERJ) and Conselho Nacional de Desenvolvimento
   Cienti fico e Tecnologico (CNPq). The funders had no role in study
   design, data collection and analysis, decision to publish, or
   preparation of the manuscript.
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NR 62
TC 32
Z9 35
U1 0
U2 21
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD DEC 21
PY 2018
VL 13
IS 12
AR e0202784
DI 10.1371/journal.pone.0202784
PG 18
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA HF3QK
UT WOS:000454149400002
PM 30576325
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Sánchez, D
   Quiñones, M
   Moulay, L
   Muguerza, B
   Miguel, M
   Aleixandre, A
AF Sanchez, David
   Quinones, Mar
   Moulay, Leila
   Muguerza, Begona
   Miguel, Marta
   Aleixandre, Amaya
TI Soluble fiber-enriched diets improve inflammation and oxidative stress
   biomarkers in Zucker fatty rats
SO PHARMACOLOGICAL RESEARCH
LA English
DT Article
DE Fiber; Inflammation; Obesity; Oxidative stress; Zucker rats
ID NECROSIS-FACTOR-ALPHA; CORONARY-HEART-DISEASE; C-REACTIVE PROTEIN;
   METABOLIC-SYNDROME; CARDIOVASCULAR-DISEASE; INSULIN-RESISTANCE;
   WHOLE-GRAIN; ENDOTHELIAL DYSFUNCTION; SYSTEMIC INFLAMMATION; OBESITY
AB In this study we evaluated the effect of the administration of different soluble fiber enriched-diets on inflammatory and redox state of Zucker fatty rats. Four groups of ten 8 week-old female Zucker fatty rats were used. The four groups were respectively fed the following diets until the 15th week of life: standard diet (obese control), 10% high methoxylated apple pectin (HMAP)-, 5% soluble cocoa fiber (SCF)-, and 10% beta-glucan-enriched diets. A group of Zucker lean rats fed the standard diet was also used as control for normal values of this rat strain. The plasma levels of tumoral necrosis factor-alpha (TNF-alpha), adiponectin, and malondialdehyde (MDA) were measured at the end of treatment. The reduced glutathione liver levels were also obtained at that moment. TNF-alpha plasma levels decreased somewhat in Zucker fatty rats fed the different fibers, and MDA plasma levels significantly decreased in these animals. Nevertheless, adiponectin plasma levels increased in the Zucker fatty rats fed the SCF enriched diet, but did not change in the HMAP and the beta-glucan group. The Zucker fatty rats fed the different fiber showed a trend towards increased the reduced glutathione liver levels, but significant differences with obese control rats were only obtained in the beta-glucan group. The results obtained in this study suggest that the intake of the different soluble fiber-enriched diets that we have evaluated could prevent and/or attenuate the inflammatory and/or the prooxidative state of the metabolic syndrome. (C) 2011 Elsevier Ltd. All rights reserved.
C1 [Miguel, Marta] CSIC UAM, Inst Invest Ciencias Alimentac CIAL, Madrid 28049, Spain.
   [Sanchez, David; Quinones, Mar; Aleixandre, Amaya] U Complutense, Fac Med, Dpto Farmacol, Madrid 28040, Spain.
   [Moulay, Leila; Muguerza, Begona] Natraceut Grp SL, Valencia 46930, Spain.
C3 Consejo Superior de Investigaciones Cientificas (CSIC); CSIC-UAM -
   Instituto de Investigacion en Ciencias de la Alimentacion (CIAL)
RP Miguel, M (corresponding author), CSIC UAM, Inst Invest Ciencias Alimentac CIAL, C Nicolas Cabrera 9, Madrid 28049, Spain.
EM marta.miguel@csic.es
RI Quiñones, Mar/AAA-9225-2020; Muguerza, Begoña/AAT-3544-2021;
   Sanchez-Infantes, David/A-7055-2013; Muguerza, Begona/C-6704-2015;
   MIGUEL CASTRO, MARTA/F-6112-2011
OI Quinones, Mar/0000-0003-0180-2147; Muguerza, Begona/0000-0001-7384-8588;
   Sanchez-Infantes, David/0000-0001-6086-7501; MIGUEL CASTRO,
   MARTA/0000-0002-5525-1056
FU Natraceutical Group [206/2006]; MICINN
FX This study was supported by Natraceutical Group (206/2006 U.C.M.
   Project). We also thank Manuel Bas Caro, Technician in Pharmacology, for
   his excellent care of the rats and control of the diets in the different
   groups of animals. Miguel M. is recipient of a Ramon y Cajal contract
   from MICINN.
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NR 46
TC 44
Z9 50
U1 0
U2 31
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 1043-6618
J9 PHARMACOL RES
JI Pharmacol. Res.
PD JUL
PY 2011
VL 64
IS 1
BP 31
EP 35
DI 10.1016/j.phrs.2011.02.005
PG 5
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 781CJ
UT WOS:000291907900005
PM 21349333
DA 2025-06-11
ER

PT J
AU Bishop, SC
   Basch, S
   Futterweit, W
AF Bishop, Suzette C.
   Basch, Samuel
   Futterweit, Walter
TI POLYCYSTIC OVARY SYNDROME, DEPRESSION, AND AFFECTIVE DISORDERS
SO ENDOCRINE PRACTICE
LA English
DT Review
ID QUALITY-OF-LIFE; IMPAIRED GLUCOSE-TOLERANCE; GRADE CHRONIC INFLAMMATION;
   C-REACTIVE PROTEIN; FACTOR-KAPPA-B; METABOLIC SYNDROME;
   INSULIN-RESISTANCE; HYPERINSULINEMIC HYPERANDROGENISM;
   ORAL-CONTRACEPTIVES; EMOTIONAL DISTRESS
AB Objective: To assess the prevalence of depression and psychologic disorders and their effect on the quality of life in women with polycystic ovary syndrome.
   Methods: We performed a PubMed search of major relevant articles published during the period from 1985 to 2009 dealing with polycystic ovary syndrome, associated psychologic morbidity, and the relationship to clinical and biochemical changes affecting the quality of life.
   Results: In patients with polycystic ovary syndrome, the presence of depression and allied disorders was frequently noted to diminish mental well-being, affect, and self-worth. The symptoms often associated with this syndrome, such as hirsutism, obesity, irregular menses, and self-worth. The symptoms often associated with this syndrome, such as hirsutism, obesity, irregular menses, and subfertility, were a major source of psychologic morbidity. Obesity was the most prevalent cause of mental distress, whereas other features such its hirsutism and infertility were less well defined as major factors. Although the findings in some studies have been inconclusive, the presence of clinically significant eating disorders and a 7-fold increase in the suicide rate have been reported in women with polycystic ovary syndrome.
   Conclusion: Women with polycystic ovary syndrome have a high risk for depression and affective disorders that impair their quality of life. The presence of obesity, eating disorders, hirsutism, poor self-image, and a significant suicide rate makes evaluation of their emotional state an integral part of their assessment and treatment. For adequate treatment of the woman with polycystic ovary syndrome, it biopsychosocial model should be used, with all aspects of the patient's mental status considered before implementation of optimal intervention. (Endocr Pract. 2009;15:475-482)
C1 [Futterweit, Walter] Mt Sinai Med Ctr, Div Endocrinol Diabet & Bone Dis, Dept Med, New York, NY 10029 USA.
   [Bishop, Suzette C.] CUNY Hunter Coll, Sch Arts & Sci, Postgrad Program, New York, NY 10021 USA.
   [Basch, Samuel] Mt Sinai Med Ctr, Dept Psychiat, New York, NY 10029 USA.
C3 Icahn School of Medicine at Mount Sinai; City University of New York
   (CUNY) System; Hunter College (CUNY); Icahn School of Medicine at Mount
   Sinai
RP Futterweit, W (corresponding author), Mt Sinai Med Ctr, Div Endocrinol, Box 1055, New York, NY 10029 USA.
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NR 71
TC 22
Z9 27
U1 0
U2 11
PU AMER ASSOC CLINICAL ENDOCRINOLOGISTS
PI JACKSONVILLE
PA 245 RIVERSIDE AVENUE, STE 200, JACKSONVILLE, FL 32202 USA
SN 1530-891X
EI 1934-2403
J9 ENDOCR PRACT
JI Endocr. Pract.
PD JUL-AUG
PY 2009
VL 15
IS 5
BP 475
EP 482
DI 10.4158/EP09083.RAR
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism
GA 482XJ
UT WOS:000268923600012
PM 19454378
DA 2025-06-11
ER

PT J
AU Tohyama, D
   Yamaguchi, A
AF Tohyama, Daisuke
   Yamaguchi, Atsushi
TI A critical role of SNF1A/dAMPKα (Drosophila
   AMP-activated protein kinase α) in muscle on longevity and
   stress resistance in Drosophila melanogaster
SO BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
LA English
DT Article
DE AMPK; Longevity; Stress resistance; Drosophila melanogaster
ID EXTENDS LIFE-SPAN; INDUCED OXIDATIVE STRESS; SKELETAL-MUSCLE;
   CAENORHABDITIS-ELEGANS; C-ELEGANS; ENERGY; METABOLISM; RESTRICTION;
   SENSOR; EXPRESSION
AB Energy homeostasis and stress resistance are closely linked on aging and longevity. AMPK (AMP-activated protein kinase) is a sensor of cellular energy status activated by metabolic stress that accelerates AMP/ATP ratio, regulating cell polarity, metabolic homeostasis and sensitivity to stress resistance. AMPK could be therapeutic targets for cancer, diabetic mellitus and obesity, providing a possible link to metabolic syndrome. However, little is known how functional deficiency of AMPK affects longevity and stress resistance in vivo due to its redundancy and lethality in null-mutant. SNF1A/dAMPK alpha (CG3051) is a single orthologue for its mammalian counterparts in Drosophila melanogaster. Using time- and tissue-specific RNAi system in D. melanogaster, we found that adult-onset inhibition of dAMPK alpha especially in muscle shortens lifespan. In addition, inhibition of dAMPK alpha in muscle enhances sensitivity to paraquat and starvation stress. Real-time PCR analysis showed that inhibition of dAMPK alpha in muscle affected the transcriptional regulation of various genes in response to starvation. These results raise the possibility that muscle is one of major tissues in which AMPK plays a critical role on longevity and stress resistance and the intervention to activate AMPK in muscle could be a prominent treatment strategy for longevity. (C) 2010 Elsevier Inc. All rights reserved.
C1 [Tohyama, Daisuke; Yamaguchi, Atsushi] Chiba Univ, Grad Sch Med, Dept Neurobiol, Chuo Ku, Chiba 2608670, Japan.
C3 Chiba University
RP Yamaguchi, A (corresponding author), Chiba Univ, Grad Sch Med, Dept Neurobiol, Chuo Ku, 1-8-1 Inohana, Chiba 2608670, Japan.
EM atsyama@restaff.chiba-u.jp
CR Adams KF, 2006, NEW ENGL J MED, V355, P763, DOI 10.1056/NEJMoa055643
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NR 33
TC 39
Z9 50
U1 0
U2 13
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0006-291X
EI 1090-2104
J9 BIOCHEM BIOPH RES CO
JI Biochem. Biophys. Res. Commun.
PD MAR 26
PY 2010
VL 394
IS 1
BP 112
EP 118
DI 10.1016/j.bbrc.2010.02.126
PG 7
WC Biochemistry & Molecular Biology; Biophysics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics
GA 580UB
UT WOS:000276474800020
PM 20184862
DA 2025-06-11
ER

PT J
AU Ren, QY
   Wang, YN
   Han, XH
   Wang, QY
   Liang, GY
AF Ren, Qianyi
   Wang, Yanan
   Han, Xinhui
   Wang, Qingyi
   Liang, Guoying
TI The relationship of cardiometabolic index with bowel movement frequency:
   an NHANES-based cross-sectional analysis
SO LIPIDS IN HEALTH AND DISEASE
LA English
DT Article
DE Bowel movement frequency; Cardiometabolic index; Cross-sectional study;
   NHANES
ID METABOLIC SYNDROME; GUT MICROBIOTA; TRANSIT TIMES; OBESITY; ASSOCIATION;
   DEPRESSION; LIVER; RISK; AGE
AB Background Prior studies have indicated a notable link between gut health and metabolic syndrome (MetS). The cardiometabolic index (CMI), an innovative indicator of metabolic health, effectively predicts MetS. Bowel movement frequency (BMF) closely reflects gastrointestinal function and is a key sign of gut health. Nonetheless, the relationship between CMI and BMF is still unclear. Our research explores the possible association between these two variables. Methods This study employed 2005 to 2010 National Health and Nutrition Examination Survey data. The CMI for each participant was determined by triglycerides, high-density lipoprotein cholesterol, and the waist-to-hip ratio. Multiple regression, smooth curve fitting, and threshold effect analyses were employed to investigate the association between CMI and BMF. The association's stability across populations was assessed through subgroup analyses and interaction tests. Results The study included 9,678 participants in total. After controlling for potential confounding variables, those in the uppermost CMI quartile had a 0.69 more increase in BMF than the bottom quartile (beta = 0.69, 95% CI: 0.34, 1.03). The trend analyses showed that BMF increased steadily with the advancement of the CMI quartiles (P for trend < 0.0001). Associations between CMI and BMF were shown to be nonlinear through smooth curve fitting and threshold effect analyses. Specifically, when CMI ranged from 4.97 to 11.75, a negative connection was observed (beta = -0.78, 95% CI: -1.33, -0.23), while positive associations were identified in other ranges. Subgroup analyses and interaction tests indicated significant CMI and BMF association variations when stratified by depression and age categories (P for interaction < 0.05). Conclusions This research indicates that CMI is generally associated with an increase in BMF. However, when CMI ranges from 4.97 to 11.75, it is associated with a BMF decrease. Notably, the association of CMI and BMF is more potent in young, middle-aged, and depressed people.
C1 [Ren, Qianyi; Han, Xinhui; Wang, Qingyi] Heilongjiang Univ Chinese Med, Sch Clin Med 1, Harbin 150040, Peoples R China.
   [Wang, Yanan] Heilongjiang Univ Chinese Med, Affiliated Hosp 2, Dept Intens Care Rehabil 1, Harbin 150001, Peoples R China.
   [Liang, Guoying] Heilongjiang Univ Chinese Med, Affiliated Hosp 1, Dept Gastroenterol 1, Harbin 150040, Peoples R China.
C3 Heilongjiang University of Chinese Medicine; Heilongjiang University of
   Chinese Medicine; Heilongjiang University of Chinese Medicine
RP Liang, GY (corresponding author), Heilongjiang Univ Chinese Med, Affiliated Hosp 1, Dept Gastroenterol 1, Harbin 150040, Peoples R China.
EM lgy1976190606@sina.com
FU Natural Science Foundation of Heilongjiang Province, China
FX Not applicable.
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NR 67
TC 0
Z9 0
U1 0
U2 0
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1476-511X
J9 LIPIDS HEALTH DIS
JI Lipids Health Dis.
PD APR 24
PY 2025
VL 24
IS 1
AR 154
DI 10.1186/s12944-025-02567-w
PG 13
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA 1WO2E
UT WOS:001475353000003
PM 40275266
DA 2025-06-11
ER

PT J
AU Kwon, KM
   Kam, JH
   Kim, MY
   Kim, MY
   Chung, CH
   Kim, JK
   Linton, JA
   Eom, A
   Koh, SB
   Kang, HT
AF Kwon, Kyung-Min
   Kam, Jin-Hwa
   Kim, Min-Young
   Kim, Moon-Young
   Chung, Choon Hee
   Kim, Jong-Koo
   Linton, John A.
   Eom, Aeyong
   Koh, Sang-Baek
   Kang, Hee-Taik
TI Inverse Association Between Total Bilirubin and Metabolic Syndrome in
   Rural Korean Women
SO JOURNAL OF WOMENS HEALTH
LA English
DT Article
ID NUTRITION EXAMINATION SURVEY; OXIDATIVE STRESS; INSULIN-RESISTANCE;
   SERUM BILIRUBIN; NATIONAL-HEALTH; SMOKING; DISEASE; INDUCTION; NHANES;
   LEVEL
AB Background: Chronic inflammation and oxidative stress are associated with the development of metabolic syndrome (MetS). Bilirubin is an antioxidant and has a protective effect against cardiovascular disease (CVD). The purpose of this study was to examine the association between total bilirubin levels and the prevalence of MetS in rural Korean women.
   Methods: This cross-sectional study included 5,266 women (>40 years) enrolled in the Korean Genomic Rural Cohort (KGRC). MetS was defined using the American Heart Association/National Heart, Lung, and Blood Institute (AHA/NHLBI) guidelines. Total bilirubin levels were categorized into quartiles.
   Results: Subjects in the upper quartiles of total bilirubin were younger and had lower waist circumferences, systolic blood pressure, and triglyceride levels and higher high-density lipoprotein cholesterol (HDL-C) concentrations. The overall prevalence of MetS was 39.0%. When the participants were categorized into quartiles by total bilirubin level, the prevalence of MetS according to increasing total bilirubin quartiles was 47.9%, 41.2%, 34.3%, and 32.7%, respectively. By comparison to the lowest quartile of total bilirubin (<0.61mg/dL), the odds ratio (OR) (95% confidence interval [CI]) for MetS in the highest quartile of total bilirubin (>= 0.94mg/dL) was 0.63 (0.52-0.77) after adjusting for menopausal status, C-reactive protein (CRP) levels, insulin resistance, and other covariates.
   Conclusions: Total bilirubin level appears to be inversely associated with the prevalence of MetS in rural Korean women >40 years of age in the KGRC, even after adjusting for risk factors of MetS, including body mass index (BMI), menopausal status, CRP levels, and homeostasis model assessment of insulin resistance (HOMA-IR).
C1 [Kwon, Kyung-Min] Yonsei Univ, Dept Family Med, Wonju Coll Med, Wonju 449930, South Korea.
   [Linton, John A.] Yonsei Univ, Coll Med, Severance Hosp, Int Hlth Care Ctr, Seoul, South Korea.
   [Eom, Aeyong] Mokpo Natl Univ, Dept Nursing, Mokpo, South Korea.
   [Kang, Hee-Taik] Yonsei Univ, Dept Med, Grad Sch, Seoul 120749, South Korea.
C3 Yonsei University; Yonsei University; Yonsei University Health System;
   Mokpo National University; Yonsei University
RP Kang, HT (corresponding author), Yonsei Univ, Dept Family Med, Wonju Coll Med, Gangwon Do 220-710, Wonju 449930, South Korea.
EM kohhj@yonsei.ac.kr; knury@naver.com
RI Kim, Young/T-8521-2019; Cho, Young/J-5669-2012; Kim, Min/N-1961-2015;
   Lee, JongGu/B-7384-2013
OI Kang, Hee-Taik/0000-0001-8048-6247; Linton, John/0000-0001-8000-3049;
   Chung, Choon/0000-0003-1144-7206
FU Korean Centers for Disease Control and Prevention [2005-E71013-00,
   2006-E71002-00, 2007-E71013-00]
FX We thank all members in the Cohort study in Wonju Christian Hospital for
   helpful discussion and comments. This study was supported in part by a
   grant from the Korean Centers for Disease Control and Prevention
   (Reseach Serial Number: 2005-E71013-00, 2006-E71002-00, and
   2007-E71013-00).
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NR 47
TC 36
Z9 39
U1 0
U2 9
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-9996
EI 1931-843X
J9 J WOMENS HEALTH
JI J. Womens Health
PD JUN
PY 2011
VL 20
IS 6
BP 963
EP 969
DI 10.1089/jwh.2010.2453
PG 7
WC Public, Environmental & Occupational Health; Medicine, General &
   Internal; Obstetrics & Gynecology; Women's Studies
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; General & Internal
   Medicine; Obstetrics & Gynecology; Women's Studies
GA 777CG
UT WOS:000291590700016
PM 21671781
DA 2025-06-11
ER

PT J
AU Zhang, JP
   Niaura, R
   Dyer, JR
   Shen, BJ
   Todaro, JF
   McCaffery, JM
   Spiro, A
   Ward, KD
AF Zhang, Jianping
   Niaura, Raymond
   Dyer, Joshua R.
   Shen, Biing-Jiun
   Todaro, John F.
   McCaffery, Jeanne M.
   Spiro, Avron, III
   Ward, Kenneth D.
TI Hostility and urine norepinephrine interact to predict insulin
   resistance: The VA normative aging study
SO PSYCHOSOMATIC MEDICINE
LA English
DT Article
DE hostility; norepinephrine; insulin resistance; HOMA; metabolic syndrome
ID HOMEOSTASIS MODEL ASSESSMENT; METABOLIC SYNDROME;
   CARDIOVASCULAR-DISEASE; GLUCOSE-TOLERANCE; ADIPOSE-TISSUE; CHRONIC
   STRESS; RISK-FACTORS; SENSITIVITY; PATHOGENESIS; CYNICISM
AB Objective: Previous research has produced mixed results pertaining to the association between hostility and insulin resistance. These inconsistent findings may be the result of a lack of studies examining potential moderators of this relationship and inconsistent measures of insulin resistance and/or hostility. We hypothesized that hostility may interact with circulating norepinephrine (KEPI) levels, indexed by 24-hour urine concentrations, to affect insulin resistance. Methods: Six hundred forty-three men (mean age = 63.1 years) free of diabetic medications completed the Minnesota Multiphasic Personality Inventory and participated in a laboratory assessment. The Cook-Medley Hostility (Ho) and 24-hour urine NEPI were used to predict insulin resistance defined by the homeostatic model assessment (HOMA) index, 2-hour postchallenge glucose (PCGL), and insulin levels (PCIL) after controlling for nine common covariates. Results: Multiple regression showed that the two-way interaction between Ho and NEPI significantly predicted HOMA and PCIL, but not PCGL, after controlling for covariates. Simple regression slopes of Ho on HOMA and PCIL were explored and indicated that, at higher levels of NEPI, higher Ho was associated with higher HOMA (beta = 0.14, p < .05). Ho was not a significant predictor of HOMA at mean and lower levels of NEPI. Similar results were obtained for PCIL, but not PCGL. Cynicism, but not other subscales of Ho, was similarly related to insulin resistance and NEPI. Conclusion: Individuals with high stress and high hostility were more likely to have insulin resistance. It is important to study moderators in the relationship between hostility and insulin resistance.
C1 Indiana Univ Purdue Univ, Dept Psychol, Indianapolis, IN 46205 USA.
   Butler Hosp, Providence, RI 02906 USA.
   Brown Univ, Sch Med, Providence, RI 02912 USA.
   Univ Miami, Dept Psychol, Miami, FL 33152 USA.
   Miriam Hosp, Ctr Behav Med, Providence, RI 02906 USA.
   Miriam Hosp, Ctr Prevent Med, Providence, RI 02906 USA.
   Brown Univ, Sch Med, Providence, RI 02912 USA.
   Boston Univ, Sch Publ Hlth, Boston, MA 02215 USA.
   VA Boston Healthcare Syst, Massachussetts Vet Epidemiol Res Informat Ctr, MAVERIC, Boston, MA USA.
   Univ Memphis, Dept Hlth & Sport Sci, Memphis, TN 38152 USA.
   Univ Memphis, Ctr Community Hlth, Memphis, TN 38152 USA.
C3 Purdue University System; Purdue University; Purdue University in
   Indianapolis; Butler Hospital Rhode Island; Brown University; University
   of Miami; Lifespan Health Rhode Island; Miriam Hospital; Lifespan Health
   Rhode Island; Miriam Hospital; Brown University; Boston University;
   Harvard University; Harvard University Medical Affiliates; US Department
   of Veterans Affairs; Veterans Health Administration (VHA); VA Boston
   Healthcare System; University of Memphis; University of Memphis
RP Zhang, JP (corresponding author), Cleveland Clin Fdn, Dept Psychiat & Psychol, 9500 Euclid Ave,P57, Cleveland, OH 44195 USA.
EM jpzhang2005@gmail.com
RI She, Ji/AAW-6150-2021; Niaura, Raymond/AAE-7319-2019; Zhang,
   Jian-Ping/L-9805-2016
OI Spiro III, Avron/0000-0003-4080-8621; McCaffery,
   Jeanne/0000-0002-2166-5840; Zhang, Jian-Ping/0000-0001-6363-6362
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NR 62
TC 37
Z9 43
U1 0
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0033-3174
EI 1534-7796
J9 PSYCHOSOM MED
JI Psychosom. Med.
PD SEP-OCT
PY 2006
VL 68
IS 5
BP 718
EP 726
DI 10.1097/01.psy.0000228343.89466.11
PG 9
WC Psychiatry; Psychology; Psychology, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry; Psychology
GA 093YH
UT WOS:000241205700011
PM 17012525
DA 2025-06-11
ER

PT J
AU Caturano, A
   Rocco, M
   Tagliaferri, G
   Piacevole, A
   Nilo, D
   Di Lorenzo, G
   Iadicicco, I
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   Sardu, C
   Russo, V
   Vetrano, E
   Conte, C
   Marfella, R
   Rinaldi, L
   Sasso, FC
AF Caturano, Alfredo
   Rocco, Maria
   Tagliaferri, Giuseppina
   Piacevole, Alessia
   Nilo, Davide
   Di Lorenzo, Giovanni
   Iadicicco, Ilaria
   Donnarumma, Mariarosaria
   Galiero, Raffaele
   Acierno, Carlo
   Sardu, Celestino
   Russo, Vincenzo
   Vetrano, Erica
   Conte, Caterina
   Marfella, Raffaele
   Rinaldi, Luca
   Sasso, Ferdinando Carlo
TI Oxidative Stress and Cardiovascular Complications in Type 2 Diabetes:
   From Pathophysiology to Lifestyle Modifications
SO ANTIOXIDANTS
LA English
DT Review
DE oxidative stress; type 2 diabetes mellitus; cardiovascular
   complications; lifestyle interventions; Mediterranean diet;
   pathophysiology
ID GLYCATION END-PRODUCTS; NITRIC-OXIDE SYNTHASE; ENDOTHELIAL DYSFUNCTION;
   PROTEIN-KINASE; MITOCHONDRIAL DYNAMICS; METABOLIC SYNDROME; ALDOSE
   REDUCTASE; HEALTH-BENEFITS; ADIPOSE-TISSUE; EXERCISE
AB Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder that significantly increases the risk of cardiovascular disease, which is the leading cause of morbidity and mortality among diabetic patients. A central pathophysiological mechanism linking T2DM to cardiovascular complications is oxidative stress, defined as an imbalance between reactive oxygen species (ROS) production and the body's antioxidant defenses. Hyperglycemia in T2DM promotes oxidative stress through various pathways, including the formation of advanced glycation end products, the activation of protein kinase C, mitochondrial dysfunction, and the polyol pathway. These processes enhance ROS generation, leading to endothelial dysfunction, vascular inflammation, and the exacerbation of cardiovascular damage. Additionally, oxidative stress disrupts nitric oxide signaling, impairing vasodilation and promoting vasoconstriction, which contributes to vascular complications. This review explores the molecular mechanisms by which oxidative stress contributes to the pathogenesis of cardiovascular disease in T2DM. It also examines the potential of lifestyle modifications, such as dietary changes and physical activity, in reducing oxidative stress and mitigating cardiovascular risks in this high-risk population. Understanding these mechanisms is critical for developing targeted therapeutic strategies to improve cardiovascular outcomes in diabetic patients.
C1 [Caturano, Alfredo; Rocco, Maria; Tagliaferri, Giuseppina; Piacevole, Alessia; Nilo, Davide; Di Lorenzo, Giovanni; Iadicicco, Ilaria; Donnarumma, Mariarosaria; Galiero, Raffaele; Sardu, Celestino; Vetrano, Erica; Marfella, Raffaele; Sasso, Ferdinando Carlo] Univ Campania Luigi Vanvitelli, Dept Adv Med & Surg Sci, I-80138 Naples, Italy.
   [Caturano, Alfredo; Conte, Caterina] San Raffaele Roma Open Univ, Dept Human Sci & Promot Qual Life, I-00166 Rome, Italy.
   [Acierno, Carlo] Azienda Osped Reg San Carlo, I-85100 Potenza, Italy.
   [Russo, Vincenzo] Temple Univ, Coll Sci & Technol, Sbarro Inst Canc Res & Mol Med, Ctr Biotechnol,Dept Biol, Philadelphia, PA 19122 USA.
   [Russo, Vincenzo] Univ Campania Luigi Vanvitelli, Dept Med Translat Sci, Div Cardiol, I-80138 Naples, Italy.
   [Conte, Caterina] IRCCS MultiMed, Dept Endocrinol Nutr & Metab Dis, I-20099 Milan, Italy.
   [Rinaldi, Luca] Univ Molise, Dept Med & Hlth Sci Vincenzo Tiberio, I-86100 Campobasso, Italy.
C3 Universita della Campania Vanvitelli; Pennsylvania Commonwealth System
   of Higher Education (PCSHE); Temple University; Universita della
   Campania Vanvitelli; IRCCS Multimedica; University of Molise
RP Sasso, FC (corresponding author), Univ Campania Luigi Vanvitelli, Dept Adv Med & Surg Sci, I-80138 Naples, Italy.; Rinaldi, L (corresponding author), Univ Molise, Dept Med & Hlth Sci Vincenzo Tiberio, I-86100 Campobasso, Italy.
EM alfredo.caturano@unicampania.it; maria.rocco@studenti.unicampania.it;
   giuseppina.tagliaferri@gmail.com; alessia0694@hotmail.it;
   nilodavide@gmail.com; giuann86@gmail.com; ilariaiad@gmail.com;
   mariarosaria.donnarumma@unicampania.it; raffaele.galiero@unicampania.it;
   carlo894@gmail.com; celestino.sardu@unicampania.it; v.p.russo@libero.it;
   erica.vetrano@unicampania.it; caterina.conte@uniroma5.it;
   raffaele.marfella@unicampania.it; luca.rinaldi@unimol.it;
   ferdinandocarlo.sasso@unicampania.it
RI Sasso, Ferdinando Carlo/AAE-5665-2019; Conte, Caterina/Z-4807-2019;
   Sardu, Celestino/AAA-7451-2019; Marfella, Raffaele/AAH-2595-2019;
   Galiero, Raffaele/KTP-8361-2024; Caturano, Alfredo/AAA-4014-2022;
   Caturano, Alfredo/ACM-4169-2022; Russo, Vincenzo/ABH-1766-2020
OI Galiero, Raffaele/0000-0002-7766-3430; Nilo, Davide/0009-0000-9617-4491;
   Sasso, Ferdinando Carlo/0000-0002-9142-7848; Conte,
   Caterina/0000-0001-7066-5292; Acierno, Carlo/0000-0002-1239-7012;
   Caturano, Alfredo/0000-0001-7761-7533; marfella,
   raffaele/0000-0003-3960-9270; Russo, Vincenzo/0000-0002-9227-0360;
   Sardu, Celestino/0000-0001-5099-3790
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NR 261
TC 9
Z9 9
U1 7
U2 7
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD JAN
PY 2025
VL 14
IS 1
AR 72
DI 10.3390/antiox14010072
PG 28
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA T3I1V
UT WOS:001403978400001
PM 39857406
OA gold
DA 2025-06-11
ER

PT J
AU Wang, CF
   Wu, MZ
   Arvapalli, R
   Dai, XN
   Mahmood, M
   Driscoll, H
   Rice, KM
   Blough, E
AF Wang, Cuifen
   Wu, Miaozong
   Arvapalli, Ravikumar
   Dai, Xiaoniu
   Mahmood, Muhammad
   Driscoll, Henry
   Rice, Kevin M.
   Blough, Eric
TI Acetaminophen Attenuates Obesity-Related Renal Injury Through
   ER-Mediated Stress Mechanisms
SO CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
LA English
DT Article
DE Obesity; Acetaminophen; Kidney; Endoplasmic reticulum stress;
   Lipotoxicity; Apoptosis
ID ENDOPLASMIC-RETICULUM STRESS; CHRONIC KIDNEY-DISEASE; METABOLIC
   SYNDROME; GLUCOSE-HOMEOSTASIS; MICE; PREVALENCE; APOPTOSIS; LINKS; RATS
AB Background/Aims: Obesity is an independent risk factor for the development of kidney disease. The purpose of this study was to determine how obesity may contribute to renal damage and whether acetaminophen ingestion can diminish obesity-associated renal cell injury in the obese Zucker rat model. Methods: Male obese Zucker rats (4 weeks old, n=6) were treated with acetaminophen (30 mg / kg body weight / day) for 26 weeks. Age matches obese control (OC),obese vehicle (OV, 0.073 mL DMSO/kg/d), and lean Zucker rats (LC) were used to determine the effects of treatment and obesity. Results: Compared to lean control rats, renal lipid deposition, expression of the endoplasmic reticulum (ER) stress protein GRP78 and activation of the ER stress-related eIF2 alpha-ATF4-CHOP, capcase 12,and JNK-MAPK signaling pathways were increased in the obese control and obese vehicle rats. These alterations were associated with the elevated renal cell apoptosis and urinary albumin excretion. Acetaminophen treatment decreased renal lipid deposition, ER-stress related signaling, apoptosis and albuminuria. Conclusion: These data suggest that the protective effects of low dose acetaminophen on renal injury are mediated, at least in part, through attenuation of ER stress. Copyright (C) 2014 S. Karger AG, Basel
C1 [Wang, Cuifen; Wu, Miaozong; Arvapalli, Ravikumar; Rice, Kevin M.; Blough, Eric] Marshall Univ, Ctr Diagnost Nanosyst, Huntington, WV 25755 USA.
   [Wang, Cuifen; Wu, Miaozong; Arvapalli, Ravikumar; Blough, Eric] Marshall Univ, Sch Pharm, Huntington, WV 25755 USA.
   [Wu, Miaozong; Mahmood, Muhammad; Driscoll, Henry; Blough, Eric] Marshall Univ, Dept Internal Med, Joan C Edwards Sch Med, Huntington, WV 25755 USA.
   [Dai, Xiaoniu] Southeast Univ, Med Sch, Nanjing, Jiangsu, Peoples R China.
C3 Marshall University; Marshall University; Marshall University; Southeast
   University - China
RP Wu, MZ (corresponding author), Marshall Univ, Ctr Diagnost Nanosyst, MEB SOP 208,1 John Marshall Dr, Huntington, WV 25755 USA.
EM wum@marshall.edu; blough@marshall.edu
RI Rice, Kevin/HTL-7237-2023; Wu, Miaozong/C-1344-2009
OI Rice, Kevin/0000-0002-5785-3405
FU Department of Energy [DE-SC0005162]; U.S. Department of Energy (DOE)
   [DE-SC0005162] Funding Source: U.S. Department of Energy (DOE)
FX This work was supported by the Department of Energy grant #DE-SC0005162.
   The funders had no role in study design,data collection and
   analysis,preparation of the manuscript, or decision to publish.The
   authors would like to acknowledge the support of the Huntington VA
   Medical Center and the Joan C.Edwards School of Medicine Training
   Program in Endocrinology for technical support,laboratory space and
   equipment.
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NR 35
TC 16
Z9 16
U1 0
U2 6
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1015-8987
EI 1421-9778
J9 CELL PHYSIOL BIOCHEM
JI Cell. Physiol. Biochem.
PY 2014
VL 33
IS 4
BP 1139
EP 1148
DI 10.1159/000358683
PG 10
WC Cell Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Physiology
GA AH9VO
UT WOS:000336493100023
PM 24731963
OA gold
DA 2025-06-11
ER

PT J
AU Lin, JA
   Wu, CH
   Yen, GC
AF Lin, Jer-An
   Wu, Chi-Hao
   Yen, Gow-Chin
TI Methylglyoxal displays colorectal cancer-promoting properties in the
   murine models of azoxymethane and CT26 isografts
SO FREE RADICAL BIOLOGY AND MEDICINE
LA English
DT Article
DE Carbonyl stress; Colon cancer; Inflammation; Methylglyoxal; Oxidative
   stress
ID GLYCATION END-PRODUCTS; METABOLIC SYNDROME; DICARBONYL STRESS; OXIDATIVE
   STRESS; DNA-DAMAGE; APOPTOSIS; CELLS; RISK; INFLAMMATION; EXPRESSION
AB Methylglyoxal (MG), a highly reactive carbonyl species (RCS) with pro-oxidant and proinflammatory properties, may be a colon tumor-promoting factor in food and biological systems. In the present study, we found that consumption of MG significantly deteriorated azoxymethane (AOM)-induced colonic preneoplastic lesions in ICR mice, in which biomarkers of oxidative stress and inflammation within the body and feces induced by MG-fueled carbonyl stress may have played important roles. Interestingly, exposure to MG also led to increases in the serum low-density lipoprotein (LDL)/high-density lipoprotein (HDL) ratio and fecal bile acid levels in mice, which may be critical factors involved in MG-induced colonic lesions. Additionally, MG treatment (50 mg/kg body weight (BW); intraperitoneally) promoted tumor growth of CT26 isografts in mice partly by carbonyl stress-evoked protumorigenic responses, including low-grade inflammation and oxidative stress. Furthermore, primary tumor cells isolated from mice with MG-induced CT26 isografts had greater proliferative and migratory activities as well as stem-like properties compared to those isolated from the vehicle controls. Excitingly, enhanced expression or activation of proteins that modulate cell survival, proliferation, or migration/invasion was also observed in those cells. In conclusion, it is conceivable that MG-induced carbonyl stress may be the pivotal promoter involved in colon cancer progression.
C1 [Lin, Jer-An; Yen, Gow-Chin] Natl Chung Hsing Univ, Dept Food Sci & Biotechnol, 145 Xingda Rd, Taichung 40227, Taiwan.
   [Wu, Chi-Hao] Natl Taiwan Normal Univ, Dept Human Dev & Family Studies, 162,Sect 1,Heping E Rd, Taipei 106, Taiwan.
   [Yen, Gow-Chin] Natl Chung Hsing Univ, Grad Inst Food Safety, 145 Xingda Rd, Taichung 40227, Taiwan.
C3 National Chung Hsing University; National Taiwan Normal University;
   National Chung Hsing University
RP Yen, GC (corresponding author), Natl Chung Hsing Univ, Dept Food Sci & Biotechnol, 145 Xingda Rd, Taichung 40227, Taiwan.
EM gcyen@nchu.edu.tw
RI Wu, chihao/G-3512-2011; Yen, Gow-Chin/B-7886-2009; Lin,
   Jer-An/O-1576-2015
OI Yen, Gow-Chin/0000-0001-9538-4219; Wu, ChiHao/0000-0001-7243-3436; Lin,
   Jer-An/0000-0002-1362-1370
FU Ministry of Education, Taiwan, R.O.C. under ATU plan
FX This research work was supported in part by the Ministry of Education,
   Taiwan, R.O.C. under the ATU plan.
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NR 64
TC 21
Z9 21
U1 1
U2 15
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0891-5849
EI 1873-4596
J9 FREE RADICAL BIO MED
JI Free Radic. Biol. Med.
PD FEB 1
PY 2018
VL 115
BP 436
EP 446
DI 10.1016/j.freeradbiomed.2017.12.020
PG 11
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA FS3UN
UT WOS:000419709200039
PM 29269310
DA 2025-06-11
ER

PT J
AU de Castro, AGC
   Bajbouj, M
   Schlattmann, P
   Lemke, H
   Heuser, I
   Neu, P
AF de Castro, A. Gomez-Carrillo
   Bajbouj, M.
   Schlattmann, P.
   Lemke, H.
   Heuser, I.
   Neu, P.
TI Cerebrovascular reactivity in depressed patients without vascular risk
   factors
SO JOURNAL OF PSYCHIATRIC RESEARCH
LA English
DT Article
DE cerebrovascular reactivity; depression; vascular risk factor; metabolic
   syndrome; non-smokers
ID CEREBRAL-BLOOD-FLOW; TRANSCRANIAL DOPPLER; POTASSIUM CHANNELS; MAJOR
   DEPRESSION; FOLLOW-UP; STROKE; SYMPTOMS; ACETAZOLAMIDE; DISORDERS;
   MORTALITY
AB Introduction: Cerebrovascular reactivity (CVR) seems to be gaining importance as a prognostic factor for stroke risk. CVR reflects the compensatory dilatory capacity of cerebral arterioles to a dilatory stimulus; this mechanism plays an important role in maintaining a constant cerebral blood flow. Evaluating factors that influence CVR will help prevention or early detection of cerebrovascular disease (CVD). In this study we aimed to measure the CVR in vascular-risk free depressed individuals so as to evaluate the effect depression has on CVR and hence its role as a stroke risk factor.
   Methods: Using acetazolamid (ACZ) stimulation, CVR was assessed with a transcranial Doppler ultrasound in 25 non-smoking depressed patients (average age: 48.48 +/- 14.40) and in 25 healthy non-smoking controls (average age: 46.76 +/- 13.69) by calculating the difference between the maximal mean blood flow velocity at baseline and the maximal mean blood flow velocity after ACZ stimulation.
   Results: Basal Cerebral Blood flow in Patients was 50.6 cm/s (SD: 11.6) versus controls 52.80 cm/s (SD: 12.70) whereas after stimulation maximal blood flow velocity was 72.64 cm/s (SD: 15.75) in patients versus 80.20 cm/s (SD: 18.43) in controls. In an analysis of covariance we found that cerebrovascular reactivity was significantly reduced in the vascular-risk free depressed sample. Age had a significant influence whereas gender did not.
   Discussion: Major Depression appears to decrease cerebrovascular reactivity supporting the idea of increased risk for stroke in depressed patients. The mechanisms leading to this phenomenon and its subtle subgroup differences should be further investigated. (c) 2006 Elsevier Ltd. All rights reserved.
C1 Charite Univ Med Berlin, Dept Psychiat, D-14050 Berlin, Germany.
   Charite Univ Med Berlin, Dept Biometry, D-14050 Berlin, Germany.
C3 Berlin Institute of Health; Free University of Berlin; Humboldt
   University of Berlin; Charite Universitatsmedizin Berlin; Berlin
   Institute of Health; Free University of Berlin; Humboldt University of
   Berlin; Charite Universitatsmedizin Berlin
RP Neu, P (corresponding author), Charite Univ Med Berlin, Dept Psychiat, Campus Benjamin Franklin,Eschenalle 3, D-14050 Berlin, Germany.
EM peter.neu@charite.de
RI Bajbouj, Malek/B-3579-2012; Schlattmann, Peter/B-5289-2008
OI Bajbouj, Malek/0000-0002-0073-3322; Heuser, Isabella/0000-0001-7075-1158
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NR 33
TC 23
Z9 26
U1 0
U2 3
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-3956
J9 J PSYCHIATR RES
JI J. Psychiatr. Res.
PD JAN
PY 2008
VL 42
IS 1
BP 78
EP 82
DI 10.1016/j.jpsychires.2006.10.001
PG 5
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 231TX
UT WOS:000250973200009
PM 17113598
DA 2025-06-11
ER

PT J
AU Unno, K
   Noda, S
   Nii, H
   Kawasaki, Y
   Iguchi, K
   Yamada, H
AF Unno, Keiko
   Noda, Shigenori
   Nii, Hirohiko
   Kawasaki, Yohei
   Iguchi, Kazuaki
   Yamada, Hiroshi
TI Anti-stress Effect of β-Cryptoxanthin in Satsuma Mandarin Orange on
   Females
SO BIOLOGICAL & PHARMACEUTICAL BULLETIN
LA English
DT Article
DE stress; clinical study; salivary alpha-amylase; orange juice
ID SALIVARY ALPHA-AMYLASE; HIGH SERUM CAROTENOIDS; PSYCHOSOCIAL STRESS;
   LOWERED CAFFEINE; GREEN TEA; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   JAPANESE SUBJECTS; DIURNAL COURSE; LOWER RISK
AB Beta-cryptoxanthin (beta-CRX, (3R)-beta, beta-caroten-3-ol) is an oxygenated carotenoid and a potent antioxidant that is abundant in Satsuma mandarin orange (Citrus unshiu MARC.), which is the most popular fruit in Japan. Since our preliminary data suggested that the ingestion of beta-CRX had an anti-stress effect in female participants, the effect was evaluated in another set of female participants. The study design was a double-blind group comparison and participants (n =23) were randomly assigned to beta-CRX-rich orange juice or placebo (beta-CRX was removed from orange juice) groups. beta-CRX or placebo juice (125 mL, after breakfast) were consumed from 1 week prior to pharmacy practice and continued for 5d into the practice period. Salivary alpha-amylase activity (sAA), a marker of sympathetic nervous system activity, was significantly higher in the evening than in the morning in the placebo-group during pharmacy practice, but not in the beta-CRX-group. This result supports the anti-stress effect of beta-CRX. The dose-dependency of beta-CRX was observed in male mice that were loaded with stress. These results indicate that the ingestion of beta-CRX is helpful to reduce stress.
C1 [Unno, Keiko; Iguchi, Kazuaki] Univ Shizuoka, Sch Pharmaceut Sci, Dept Neurophysiol, Suruga Ku, 52-1 Yada, Shizuoka 4228526, Japan.
   [Unno, Keiko] Univ Shizuoka, Grad Sch Integrated Pharmaceut & Nutr Sci, Tea Sci Ctr, Suruga Ku, 52-1 Yada, Shizuoka 4228526, Japan.
   [Noda, Shigenori; Nii, Hirohiko; Yamada, Hiroshi] Univ Shizuoka, Sch Pharmaceut Sci, Div Drug Evaluat & Informat, Suruga Ku, 52-1 Yada, Shizuoka 4228526, Japan.
   [Kawasaki, Yohei] Chiba Univ Hosp, Biostat Sect, Chuo Ku, 1-8-1 Inohana, Chiba 2608677, Japan.
C3 University of Shizuoka; University of Shizuoka; University of Shizuoka;
   Chiba University
RP Unno, K (corresponding author), Univ Shizuoka, Sch Pharmaceut Sci, Dept Neurophysiol, Suruga Ku, 52-1 Yada, Shizuoka 4228526, Japan.; Unno, K (corresponding author), Univ Shizuoka, Grad Sch Integrated Pharmaceut & Nutr Sci, Tea Sci Ctr, Suruga Ku, 52-1 Yada, Shizuoka 4228526, Japan.
EM unno@u-shizuoka-ken.ac.jp
FU  [KAKENHI 23617014]
FX The authors thank all participants of the study and Ehime Beverage Inc.
   for providing Satsuma Mandarin orange juice. This research study was
   supported by a Grant-in-Aid for Scientific Research (KAKENHI 23617014)
   and a Grant for specially promoted research of the University of
   Shizuoka.
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NR 32
TC 5
Z9 6
U1 0
U2 4
PU PHARMACEUTICAL SOC JAPAN
PI TOKYO
PA 2-12-15 SHIBUYA, SHIBUYA-KU, TOKYO, 150-0002, JAPAN
SN 0918-6158
J9 BIOL PHARM BULL
JI Biol. Pharm. Bull.
PD AUG
PY 2019
VL 42
IS 8
BP 1402
EP 1408
DI 10.1248/bpb.b19-00325
PG 7
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Pharmacology & Pharmacy
GA IN7JZ
UT WOS:000478859000019
PM 31366875
OA gold
DA 2025-06-11
ER

PT J
AU Gómez-Pérez, D
   Cancino, M
   Moreno, PI
   Ortiz, MS
AF Gomez-Perez, Daniela
   Cancino, Margarita
   Moreno, Patricia I.
   Ortiz, Manuel S.
TI Weight Stigma, Chronic Stress, Unhealthy Diet, and Obesity in Chilean
   Adults
SO INTERNATIONAL JOURNAL OF BEHAVIORAL MEDICINE
LA English
DT Article
DE Weight stigma; Obesity; Chronic stress; Unhealthy diet
ID DEPRESSIVE SYMPTOMS; PHYSICAL-ACTIVITY; LIFE-STYLE; HEALTH;
   CONSEQUENCES; DETERMINANTS; OVERWEIGHT; AVOIDANCE; NUTRITION; DISEASE
AB Background Obesity is highly prevalent around the world, including in Chile. Although various psychological factors have been previously associated with obesity, there has been less attention on the role of weight stigma as a determinant of obesity in Chile. Therefore, the primary aim of this study was to examine the direct effect of weight stigma on obesity and determine whether chronic stress and unhealthy diet mediate the relationship between weight stigma and obesity. Methods Faculty and staff from a Chilean university enrolled in the Chilean Study of Psychological Predictors of Obesity and Metabolic Syndrome and completed anthropometric measurements and measures of weight stigma, chronic stress, and unhealthy diet. Results Three-hundred and eighty-three participants (M-age= 45 years old; 58% female) were included in the present analysis. Structural equation model analyses demonstrated a direct effect of weight stigma on obesity, chronic stress, and unhealthy diet. However, chronic stress and unhealthy diet did not mediate the relationship between weight stigma and obesity. Conclusions Weight stigma is an important determinant of obesity and is associated with high levels of chronic stress and unhealthy diet in Chilean adults. Our results provide further support for the multifactorial nature of obesity and can inform future interventions aimed promoting weight loss in people with overweight and obesity.
C1 [Gomez-Perez, Daniela; Cancino, Margarita; Ortiz, Manuel S.] Univ La Frontera, Dept Psychol, Temuco 0830, Chile.
   [Moreno, Patricia I.] Northwestern Univ, Dept Med Social Sci, Feinberg Sch Med, Chicago, IL 60611 USA.
C3 Universidad de La Frontera; Northwestern University; Feinberg School of
   Medicine
RP Gómez-Pérez, D (corresponding author), Univ La Frontera, Dept Psychol, Temuco 0830, Chile.
EM daniela.gomez@ufrontera.cl; margarita.cancino@ufrontera.cl;
   patricia.moreno@northwestern.edu; manuel.ortiz@ufrontera.cl
RI Gómez-Pérez, Daniela/KPB-4059-2024; Ortiz, Manuel/G-1044-2019
OI Ortiz, Manuel/0000-0002-7749-0699; Moreno, Patricia
   I./0000-0002-3083-6461
FU National Commission for Scientific and Technological Research, Formation
   of Advanced Human Capital Program/Doctorado Nacional [21150016];
   Universidad de La Frontera, Postdoctoral research program UFRO
   [VRIP19P001]; National Fund for Scientific and Technological Development
   Regular [1180463]; National Fund for Scientific and Technological
   Development Postdoctoral [3180534]; Health and Behavior International
   Collaborative Award - American Psychosomatic Society
FX This study was fully funded by the National Commission for Scientific
   and Technological Research, Formation of Advanced Human Capital
   Program/Doctorado Nacional 21150016; and partially by Universidad de La
   Frontera, Postdoctoral research program UFRO, VRIP19P001; National Fund
   for Scientific and Technological Development Regular (1180463), National
   Fund for Scientific and Technological Development Postdoctoral
   (3180534); and by a Health and Behavior International Collaborative
   Award sponsored by American Psychosomatic Society.
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NR 55
TC 9
Z9 11
U1 1
U2 32
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1070-5503
EI 1532-7558
J9 INT J BEHAV MED
JI Int. J. Behav. Med.
PD JUN
PY 2021
VL 28
IS 3
BP 292
EP 298
DI 10.1007/s12529-020-09917-1
EA JUL 2020
PG 7
WC Psychology, Clinical
WE Social Science Citation Index (SSCI)
SC Psychology
GA SC4DQ
UT WOS:000545908400001
PM 32632745
DA 2025-06-11
ER

PT J
AU Luo, W
   Cao, J
   Li, H
   He, W
AF Luo, Weijia
   Cao, Jin
   Li, He
   He, Welmin
TI Adipose tissue-specific PPARγ deficiency increases resistance to
   oxidative stress
SO EXPERIMENTAL GERONTOLOGY
LA English
DT Article
DE PPAR gamma; adipose tissue; oxidative stress; antioxidant genes;
   prooxidant genes
ID IMPROVED INSULIN-SENSITIVITY; TRANSCRIPTION FACTOR FOXO3A; LIFE-SPAN;
   PRO12ALA POLYMORPHISM; CALORIE RESTRICTION; METABOLIC SYNDROME;
   DIABETES-MELLITUS; SIRT1 DEACETYLASE; REACTIVE OXYGEN; CELL-CYCLE
AB The nuclear hormone receptor peroxisome proliferator activated receptor gamma (PPAR gamma) critically regulates adipogenesis and lipogenesis. Obesity is closely associated with increased oxidative stress, and pharmacological activation of PPAR gamma by its ligands significantly suppresses oxidative stress in cultured adipocytes. On the other hand, a PPAR gamma 2(Prol2AIa) polymorphism, which decreases receptor transcription activity, is associated with lower body mass index and increased insulin sensitivity in humans. This mutation is also found to be positively associated with increased human lifespan. Here we show that adipose tissue-specific PPAR gamma heterozygous mice, which exhibit significant improvement in insulin sensitivity in skeletal muscle, show increased resistance to paraquat-induced oxidative stress. The enhanced oxidative stress tolerance is associated with significant upregulation of antioxidant genes in white adipose tissue and skeletal muscle whereas prooxidant genes are not changed. This is also associated with a significant increase in adipose tissue of Foxo3a, a transcription factor that is known to regulate clearance of reactive oxygen species. Consistently, Foxo3a dependent genes are significantly upregulated in adipose tissue. These data implicate adipose tissue PPAR gamma in the regulation of oxidative stress, which may underlie extended lifespan in humans bearing PPARy2(Prol2AIa) mutation. (c) 2007 Elsevier Inc. Ail rights reserved.
C1 [Luo, Weijia; Cao, Jin; Li, He; He, Welmin] Texas A&M Univ, Syst Hlth Sci Ctr, Inst Biosci & Technol, Ctr Environm & Genet Med, Houston, TX 77030 USA.
C3 Texas A&M University System; Texas A&M University College Station; Texas
   A&M Health Science Center
RP He, W (corresponding author), Texas A&M Univ, Syst Hlth Sci Ctr, Inst Biosci & Technol, Ctr Environm & Genet Med, 2121 W Holcombe Blvd, Houston, TX 77030 USA.
EM whe@ibt.tamhse.edu
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NR 51
TC 32
Z9 33
U1 0
U2 3
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0531-5565
EI 1873-6815
J9 EXP GERONTOL
JI Exp. Gerontol.
PD MAR
PY 2008
VL 43
IS 3
BP 154
EP 163
DI 10.1016/j.exger.2007.11.002
PG 10
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA 273GW
UT WOS:000253919400005
PM 18083318
DA 2025-06-11
ER

PT J
AU Grajales, D
   Vázquez, P
   Alén, R
   Hitos, AB
   Valverde, AM
AF Grajales, Diana
   Vazquez, Patricia
   Alen, Rosa
   Hitos, Ana B.
   Valverde, Angela M.
TI Attenuation of Olanzapine-Induced Endoplasmic Reticulum Stress Improves
   Insulin Secretion in Pancreatic Beta Cells
SO METABOLITES
LA English
DT Article
DE olanzapine; ER stress; beta cell; second-generation antipsychotics;
   schizophrenia; type 2 diabetes
ID UNFOLDED PROTEIN RESPONSE; DIABETES-MELLITUS; ER STRESS; ANTIPSYCHOTICS;
   SCHIZOPHRENIA; DYSFUNCTION; APOPTOSIS; RESISTANCE; CHAPERONE
AB Second-generation antipsychotics (SGAs), in particular, olanzapine and clozapine, have been associated with the development of type 2 diabetes mellitus (T2D) and metabolic syndrome in individuals with schizophrenia. In this context, beta cell dysfunction is a plausible mechanism by which SGAs cause T2D. Herein, we analyzed the direct effects of olanzapine, a commonly prescribed SGA with diabetogenic properties, on the INS-1 (821/13) beta cell line and isolated pancreatic islets. Treatment of INS-1 beta cells with non-toxic concentrations of olanzapine (3-6 mu M) during 4 h activated endoplasmic reticulum (ER) stress-mediated signaling by increasing PERK/eIF2 alpha phosphorylation, IRE-1 phosphorylation and XBP-1 splicing. Moreover, glucose-stimulated insulin secretion (GSIS) was inhibited when olanzapine was present for 16 h. The insulin secretory function of INS-1 cells was restored by inhibiting olanzapine-induced ER stress with tauroursodeoxycholic acid (TUDCA). Similar effects of olanzapine with or without TUDCA on ER-stress-mediated signaling and GSIS were found in pancreatic islets from female mice. Our results indicate that early activation of ER stress in pancreatic beta cells is a potential mechanism behind the alterations in glucose homeostasis induced by olanzapine.
C1 [Grajales, Diana; Vazquez, Patricia; Alen, Rosa; Hitos, Ana B.; Valverde, Angela M.] CSIC, Inst Invest Biomed Alberto Sols, Madrid 28029, Spain.
   [Grajales, Diana; Vazquez, Patricia; Alen, Rosa; Hitos, Ana B.; Valverde, Angela M.] Inst Salud Carlos III, CIBER Diabet & Enfermedades Metab Asociadas CIBER, Madrid 28029, Spain.
C3 Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Instituto
   de Investigaciones Biomedicas Alberto Sols (IIBM); CIBER - Centro de
   Investigacion Biomedica en Red; CIBERES; Instituto de Salud Carlos III
RP Valverde, AM (corresponding author), CSIC, Inst Invest Biomed Alberto Sols, Madrid 28029, Spain.; Valverde, AM (corresponding author), Inst Salud Carlos III, CIBER Diabet & Enfermedades Metab Asociadas CIBER, Madrid 28029, Spain.
EM dgrajales@iib.uam.es; patrivazquez@iib.uam.es; ralen@iib.uam.es;
   ahitos@iib.uam.es; avalverde@iib.uam.es
RI Vázquez, Patricia/GOP-0520-2022; Grajales, Diana/AAE-5877-2021
OI Grajales, Diana/0000-0002-9332-6979; Alen, Rosa/0000-0003-1876-2612; ,
   Ana Belen/0000-0002-0403-6647; Martinez Valverde,
   Angela/0000-0003-1192-9045
FU H2020 Marie Sklodowska-Curie ITN-TREATMENT, European Commission
   [721236]; MICINN//AEI (Ministerio de Ciencia e Innovacion y Fondo
   Europeo de Desarrollo Regional [FEDER, EU]) [RTI2018-094052-B-100];
   Comunidad de Madrid, Spain [S2017/BMD-3684]; Fundacion Ramon Areces
   (Spain); CIBERDEM (ISCIII, Spain)
FX This work was funded by H2020 Marie Sklodowska-Curie ITN-TREATMENT
   (grant agreement 721236), European Commission. We also acknowledge
   grants RTI2018-094052-B-100 (MICINN//AEI/10.13039/501100011033
   (Ministerio de Ciencia e Innovacion y Fondo Europeo de Desarrollo
   Regional [FEDER, EU])) and S2017/BMD-3684 (Comunidad de Madrid, Spain),
   and grants from Fundacion Ramon Areces (Spain) and CIBERDEM (ISCIII,
   Spain).
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NR 36
TC 4
Z9 5
U1 0
U2 7
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2218-1989
J9 METABOLITES
JI Metabolites
PD MAY
PY 2022
VL 12
IS 5
AR 443
DI 10.3390/metabo12050443
PG 14
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 1O5CP
UT WOS:000801350500001
PM 35629947
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Charlier, CM
   Barr, ML
   Colby, SE
   Greene, GW
   Olfert, MD
AF Charlier, Camille M.
   Barr, Makenzie L.
   Colby, Sarah E.
   Greene, Geoffrey W.
   Olfert, Melissa D.
TI Correlations of Self-Reported Androgen Deficiency in Ageing Males (ADAM)
   with Stress and Sleep among Young Adult Males
SO HEALTHCARE
LA English
DT Article
DE androgen deficiency; ADAM score; low testosterone; young adult males;
   stress; sleep
ID TESTOSTERONE DEFICIENCY; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   HYPOGONADISM; MEN; RISK; QUESTIONNAIRES; THERAPY
AB Androgen deficiency in males has traditionally been predominantly limited to older men aged 50+ years. However, little is known of the correlation between hormonal disruption, stress, and sleep in college-aged males. This cross-sectional study investigates lifestyle behavior patterns in young men and a screening for potential androgen deficiency. A survey of 409 male students, as part of a larger USDA-funded Get-Fruved study, was analyzed for this sub-project. Survey instruments used include the Androgen Deficiency in the Aging Male Questionnaire (ADAM) to assess for inadequate ADAM scores, the Perceived Stress Scale to measure stress levels and the Pittsburgh Sleep Quality Index to evaluate sleep quality. In total, 144 male participants (35%) met criteria for potential androgen deficiency defined by the ADAM questionnaire. Correlation was found between having a positive ADAM score and both increased stress levels (p < 0.001) and poor sleep quality (p < 0.001), with stress displaying the strongest effect (p < 0.001 vs p = 0.124). An increased prevalence of having a positive ADAM score versus established norms for this age group was also noted. These findings highlight the need for investigation of endocrine disruptions in young men.
C1 [Charlier, Camille M.] West Virginia Univ, Hlth Sci Ctr, Clin & Translat Sci, Morgantown, WV 26506 USA.
   [Barr, Makenzie L.; Olfert, Melissa D.] West Virginia Univ, Dept Anim & Nutr Sci, Davis Coll Agr Nat Resources & Design, Agr Sci Bldg G025, Morgantown, WV 26506 USA.
   [Colby, Sarah E.] Univ Tennessee, Dept Nutr, 1215 W Cumberland Ave,229 Jesse Harris Bldg, Knoxville, TN 37996 USA.
   [Greene, Geoffrey W.] Univ Rhode Isl, Dept Nutr & Food Sci, Kingston, RI 02881 USA.
C3 West Virginia University; West Virginia University; University of
   Tennessee System; University of Tennessee Knoxville; University of Rhode
   Island
RP Olfert, MD (corresponding author), West Virginia Univ, Dept Anim & Nutr Sci, Davis Coll Agr Nat Resources & Design, Agr Sci Bldg G025, Morgantown, WV 26506 USA.
EM ccharlie@hsc.wvu.edu; mbarr6@mix.wvu.edu; scolby@utk.edu;
   ggreene@uri.edu; Melissa.olfert@mail.wvu.edu
RI Barr, Makenzie/P-9902-2019; Olfert, Melissa/NFS-7300-2025
OI Barr-Porter, Makenzie/0000-0002-6332-215X; Olfert, Melissa
   D/0000-0002-6686-3891
FU National Institute of Food and Agriculture, U.S. Department of
   Agriculture [2014-67001-21851]
FX The authors thank Ida Holaskova for help with data analysis. Approval to
   use the dataset was granted by the University of Tennessee Institutional
   Review Board prior to study implementation. This material is based upon
   work that is supported by the National Institute of Food and
   Agriculture, U.S. Department of Agriculture, under award number
   2014-67001-21851.
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NR 30
TC 5
Z9 5
U1 0
U2 2
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2227-9032
J9 HEALTHCARE-BASEL
JI Healthcare
PD DEC
PY 2018
VL 6
IS 4
AR 121
DI 10.3390/healthcare6040121
PG 8
WC Health Care Sciences & Services; Health Policy & Services
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services
GA HH0FN
UT WOS:000455389400003
PM 30275371
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Takaki, A
   Kawai, D
   Yamamoto, K
AF Takaki, Akinobu
   Kawai, Daisuke
   Yamamoto, Kazuhide
TI Multiple Hits, Including Oxidative Stress, as Pathogenesis and Treatment
   Target in Non-Alcoholic Steatohepatitis (NASH)
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE molecular hydrogen; non-alcoholic steatohepatitis; oxidative stress
ID FATTY LIVER-DISEASE; ENDOPLASMIC-RETICULUM STRESS; HYDROGEN-RICH WATER;
   INCREASED INTESTINAL PERMEABILITY; IMPROVES HEPATIC STEATOSIS;
   INSULIN-RESISTANCE; VITAMIN-E; MOLECULAR-HYDROGEN; METABOLIC SYNDROME;
   RAT MODEL
AB Multiple parallel hits, including genetic differences, insulin resistance and intestinal microbiota, account for the progression of non-alcoholic steatohepatitis (NASH). Multiple hits induce adipokine secretion, endoplasmic reticulum (ER) and oxidative stress at the cellular level that subsequently induce hepatic steatosis, inflammation and fibrosis, among which oxidative stress is considered a key contributor to progression from simple fatty liver to NASH. Although several clinical trials have shown that anti-oxidative therapy can effectively control hepatitis activities in the short term, the long-term effect remains obscure. Several trials of long-term anti-oxidant protocols aimed at treating cerebrovascular diseases or cancer development have failed to produce a benefit. This might be explained by the non-selective anti-oxidative properties of these drugs. Molecular hydrogen is an effective antioxidant that reduces only cytotoxic reactive oxygen species (ROS) and several diseases associated with oxidative stress are sensitive to hydrogen. The progress of NASH to hepatocellular carcinoma can be controlled using hydrogen-rich water. Thus, targeting mitochondrial oxidative stress might be a good candidate for NASH treatment. Long term clinical intervention is needed to control this complex lifestyle-related disease.
C1 [Takaki, Akinobu; Kawai, Daisuke; Yamamoto, Kazuhide] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Gastroenterol & Hepatol, Kita Ku, Okayama 7008558, Japan.
C3 Okayama University
RP Takaki, A (corresponding author), Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Gastroenterol & Hepatol, Kita Ku, 2-5-1 Shikata Cho, Okayama 7008558, Japan.
EM akitaka@md.okayama-u.ac.jp; daicawai@yahoo.co.jp;
   kazuhide@md.okayama-u.ac.jp
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NR 131
TC 352
Z9 388
U1 2
U2 54
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD OCT
PY 2013
VL 14
IS 10
BP 20704
EP 20728
DI 10.3390/ijms141020704
PG 25
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 274QK
UT WOS:000328620900079
PM 24132155
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Fragasso, G
   Chierchia, SL
   Arioli, F
   Carandente, O
   Gerosa, S
   Carlino, M
   Palloshi, A
   Gianolli, L
   Calori, G
   Fazio, F
   Margonato, A
AF Fragasso, Gabriele
   Chierchia, Sergio L.
   Arioli, Francesco
   Carandente, Orazio
   Gerosa, Stefano
   Carlino, Mauro
   Palloshi, Altin
   Gianolli, Luigi
   Calori, Giliola
   Fazio, Ferruccio
   Margonato, Alberto
TI Coronary slow-flow causing transient myocardial hypoperfusion in
   patients with cardiac syndrome X: Long-term clinical and functional
   prognosis
SO INTERNATIONAL JOURNAL OF CARDIOLOGY
LA English
DT Article
DE Cardiac syndrome X; Myocardial ischemia; Myocardial perfusion
   scintigraphy; Coronary slow-flow; Prognosis
ID LEFT-VENTRICULAR FUNCTION; SYNDROME EVALUATION WISE; ANGINA-PECTORIS;
   CHEST-PAIN; FOLLOW-UP; ARTERY-DISEASE; ENDOTHELIAL DYSFUNCTION;
   CARDIOVASCULAR EVENTS; ARTERIOGRAMS; ANGIOGRAMS
AB Background: We investigated the possibility that transient coronary slow-flow as assessed during coronary angiography in patients with cardiac syndrome X may impair myocardial perfusion and the effects of this phenomenon on long-term prognosis.
   Methods: From 50 consecutive patients with cardiac syndrome X, we prospectively recruited 16 who exhibited coronary slow-flow during angiography. The remaining 34 patients served as controls. The slow-flow phenomenon was invariably worsened by nitrates and reversed by papaverine. During slow-flow, a dose of 99m-Tc-Methoxy-isobutyl-isonitrile (MIBI) was injected in 12 patients and SPECT imaging performed 1 h later. The perfusion study was repeated after 2 days at rest and, in 9 patients, at peak exercise after 10 +/- 4 days. Patients were then regularly followed-up.
   Results: All 12 patients had a significant MIBI defect in the regions served by the coronary artery that showed slow-flow just prior MIBI injection. After exercise, MIBI tomograms revealed a perfusion defect in 5 out of the 9 patients who underwent stress scanning. At 14 +/- 2 years follow-up, 1 patient with slow-flow had died and 4 developed significant coronary artery disease (CAD), while all patients of the control group were alive and none had developed significant CAD.
   Conclusions: These results show that the slow-flow phenomenon might be the cause of transient myocardial underperfusion in patients with angina and normal coronary arteries. Apparently, this phenomenon is associated with a worse cardiac prognosis. Therefore, patients with coronary slow-flow should be carefully followed-up. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
C1 [Fragasso, Gabriele] Univ Vita Salute, Cardiol Clin, Div Cardiol, Ist Sci H San Raffaele, I-20132 Milan, Italy.
   [Chierchia, Sergio L.] Villa Azzurra Hosp, Div Cardiol, Genoa, Italy.
   [Gianolli, Luigi; Fazio, Ferruccio] Univ Vita Salute, Dept Nucl Med, Ist Sci San Raffaele, Milan, Italy.
   [Fazio, Ferruccio] Univ Milano Bicocca, INB CNR, Milan, Italy.
C3 Vita-Salute San Raffaele University; IRCCS Ospedale San Raffaele;
   Vita-Salute San Raffaele University; IRCCS Ospedale San Raffaele;
   University of Milano-Bicocca
RP Fragasso, G (corresponding author), Univ Vita Salute, Cardiol Clin, Div Cardiol, Ist Sci H San Raffaele, Via Olgettina 60, I-20132 Milan, Italy.
EM fragasso.gabriele@hsr.it
RI gianolli, luigi/AAN-3892-2020; MARGONATO, ALBERTO/B-4185-2015; fragasso,
   gabriele/K-5483-2012
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NR 45
TC 47
Z9 52
U1 1
U2 4
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0167-5273
EI 1874-1754
J9 INT J CARDIOL
JI Int. J. Cardiol.
PD OCT
PY 2009
VL 137
IS 2
BP 137
EP 144
DI 10.1016/j.ijcard.2008.06.070
PG 8
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 503MT
UT WOS:000270539800007
PM 18762343
DA 2025-06-11
ER

PT J
AU Sil, R
   Chakraborti, AS
AF Sil, Rajarshi
   Chakraborti, Abhay Sankar
TI Major heme proteins hemoglobin and myoglobin with respect to their roles
   in oxidative stress - a brief review
SO FRONTIERS IN CHEMISTRY
LA English
DT Review
DE hemoglobin; myoglobin; oxidative stress; free iron; fenton reaction
ID NONENZYMATIC GLYCATION; MITOCHONDRIAL DYSFUNCTION; KIDNEY INJURY; IRON;
   CARBONYLATION; FERROPTOSIS; CELLS; NANOPARTICLES; METHYLGLYOXAL;
   GLYCYRRHIZIN
AB Oxidative stress is considered as the root-cause of different pathological conditions. Transition metals, because of their redox-active states, are capable of free radical generation contributing oxidative stress. Hemoglobin and myoglobin are two major heme proteins, involved in oxygen transport and oxygen storage, respectively. Heme prosthetic group of heme proteins is a good reservoir of iron, the most abundant transition metal in human body. Although iron is tightly bound in the heme pocket of these proteins, it is liberated under specific circumstances yielding free ferrous iron. This active iron can react with H2O2, a secondary metabolite, forming hydroxyl radical via Fenton reaction. Hydroxyl radical is the most harmful free radical among all the reactive oxygen species. It causes oxidative stress by damaging lipid membranes, proteins and nucleic acids, activating inflammatory pathways and altering membrane channels, resulting disease conditions. In this review, we have discussed how heme-irons of hemoglobin and myoglobin can promote oxidative stress under different pathophysiological conditions including metabolic syndrome, diabetes, cardiovascular, neurodegenerative and renal diseases. Understanding the association of heme proteins to oxidative stress may be important for knowing the complications as well as therapeutic management of different pathological conditions.
C1 [Sil, Rajarshi] Allied Sci Prod, Kolkata, India.
   [Chakraborti, Abhay Sankar] Univ Calcutta, Dept Biophys Mol Biol & Bioinformat, Univ Coll Sci, Kolkata, India.
C3 University of Calcutta
RP Chakraborti, AS (corresponding author), Univ Calcutta, Dept Biophys Mol Biol & Bioinformat, Univ Coll Sci, Kolkata, India.
EM abhay_chakraborti@yahoo.co.in
FU University Grants Commission; Council of Scientific and Industrial
   Research, New Delhi
FX The senior author (ASC) acknowledges the receipt of funds from
   University Grants Commission and Council of Scientific and Industrial
   Research, New Delhi to undertake different earlier studies, some of
   which have been cited as the published reports.
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NR 192
TC 1
Z9 1
U1 2
U2 2
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-2646
J9 FRONT CHEM
JI Front. Chem.
PD FEB 25
PY 2025
VL 13
AR 1543455
DI 10.3389/fchem.2025.1543455
PG 12
WC Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry
GA Z8A0Q
UT WOS:001441056000001
PM 40070406
OA gold
DA 2025-06-11
ER

PT J
AU Lee, J
   Liu, R
   de Jesus, D
   Kim, BS
   Ma, K
   Moulik, M
   Yechoor, V
AF Lee, J.
   Liu, R.
   de Jesus, D.
   Kim, B. S.
   Ma, K.
   Moulik, M.
   Yechoor, V.
TI Circadian control of -cell function and stress responses
SO DIABETES OBESITY & METABOLISM
LA English
DT Review
DE Bmal1; circadian; clock; diabetes; ER stress; insulin; islet;
   mitochondria; oxidative stress; OXPHOS; Rev-erb; shift work; UPR; -cell
ID STIMULATED INSULIN-SECRETION; ENDOPLASMIC-RETICULUM STRESS; ACTIVATED
   SIGNALING PATHWAYS; UNFOLDED PROTEIN RESPONSE; CONTROLS
   LIPID-METABOLISM; PANCREATIC BETA-CELLS; ARNT-LIKE PROTEIN-1; OXIDATIVE
   STRESS; GENE-EXPRESSION; GLUCOSE-HOMEOSTASIS
AB Circadian disruption is the bane of modern existence and its deleterious effects on health; in particular, diabetes and metabolic syndrome have been well recognized in shift workers. Recent human studies strongly implicate a dose-dependent' relationship between circadian disruption and diabetes. Genetic and environmental disruption of the circadian clock in rodents leads to diabetes secondary to -cell failure. Deletion of Bmal1, a non-redundant core clock gene, leads to defects in -cell stimulus-secretion coupling, decreased glucose-stimulated ATP production, uncoupling of OXPHOS and impaired glucose-stimulated insulin secretion. Both genetic and environmental circadian disruptions are sufficient to induce oxidative stress and this is mediated by a disruption of the direct transcriptional control of the core molecular clock and Bmal1 on Nrf2, the master antioxidant transcription factor in the -cell. In addition, circadian disruption also leads to a dysregulation of the unfolded protein response and leads to endoplasmic reticulum stress in -cells. Both the oxidative and endoplasmic reticulum (ER) stress contribute to an impairment of mitochondrial function and -cell failure. Understanding the basis of the circadian control of these adaptive stress responses offers hope to target them for pharmacological modulation to prevent and mitigate the deleterious metabolic consequences of circadian disruption.
C1 [Lee, J.; Liu, R.; de Jesus, D.; Kim, B. S.; Yechoor, V.] Baylor Coll Med, Dept Med, Diabet Res Ctr, Houston, TX 77030 USA.
   [Lee, J.; Liu, R.; de Jesus, D.; Kim, B. S.; Yechoor, V.] Baylor Coll Med, Dept Med, Div Diabet Endocrinol & Metab, Houston, TX 77030 USA.
   [Ma, K.] Methodist Hosp, Res Inst, Ctr Diabet Res, Houston, TX 77030 USA.
   [Moulik, M.] Univ Texas Med Sch Houston, Dept Pediat, Div Cardiol, Houston, TX USA.
   [Yechoor, V.] Baylor Coll Med, Dept Mol & Cellular Biol, Houston, TX 77030 USA.
C3 Baylor College of Medicine; Baylor College of Medicine; Houston
   Methodist; University of Texas System; University of Texas Health
   Science Center Houston; Baylor College of Medicine
RP Yechoor, V (corresponding author), Baylor Coll Med, DERC, R612,One Baylor Plaza, Houston, TX 77030 USA.
EM vyechoor@bcm.edu
RI Yechoor, Vijay/AAX-3244-2021
FU NIH [R01DK097160, R56 DK089061-01]; PF Grant [DRC-P30DK079638]; American
   Diabetes Association [7-12-BS-210, 1-13-BS-118]; Mouse Metabolism Core
   of the Diabetes Research Center at Baylor College of Medicine
   [DRC-P30DK079638]
FX The work was supported by grants to V.K.Y. from NIH: R01DK097160; R56
   DK089061-01; P&F Grant (DRC-P30DK079638); American Diabetes Association:
   7-12-BS-210. The work was also supported by grants to K.M. from American
   Diabetes Association (1-13-BS-118). We also thank the Mouse Metabolism
   Core of the Diabetes Research Center at Baylor College of Medicine
   (DRC-P30DK079638).
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NR 121
TC 27
Z9 29
U1 3
U2 17
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1462-8902
EI 1463-1326
J9 DIABETES OBES METAB
JI Diabetes Obes. Metab.
PD SEP
PY 2015
VL 17
SU 1
BP 123
EP 133
DI 10.1111/dom.12524
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA CQ7GF
UT WOS:000360770300018
PM 26332977
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Mathew, GM
   Hale, L
   Chang, AM
AF Mathew, Gina Marie
   Hale, Lauren
   Chang, Anne-Marie
TI Sex Moderates Relationships Among School Night Sleep Duration, Social
   Jetlag, and Depressive Symptoms in Adolescents
SO JOURNAL OF BIOLOGICAL RHYTHMS
LA English
DT Article
DE depression; adolescence; social jetlag; sleep duration; circadian
   rhythms; sex; cross-sectional
ID CORTISOL AWAKENING RESPONSE; GENDER-DIFFERENCES; METABOLIC SYNDROME;
   ADVERSE CHILDHOOD; MAJOR DEPRESSION; MIDDLE SCHOOL; UNITED-STATES;
   STUDENTS; ASSOCIATION; CHRONOTYPE
AB Social jetlag, a misalignment between sleep timing on the weekend and during the work week, is associated with depressive symptoms among adults across both sexes. A previous study found that later sleep timing was associated with depressive symptoms in women but not men. To date, however, no research has investigated whether the association between social jetlag and depression varies by sex among adolescents. The current study assessed self-reported sleep, depressive symptoms, and demographic information from 3058 adolescents (48% female, mean [SD] age 15.59 [0.77] years) from the age 15 wave of the Fragile Families and Child Wellbeing Study (FFCWS). Social jetlag was calculated as the absolute value of the midpoint of sleep on the weekend minus the midpoint of sleep during the school week. Depressive symptoms were measured through a modified 5-item version of the Center for Epidemiologic Studies Depression Scale (CES-D). We assessed whether the associations among sleep duration on school nights, social jetlag, and depressive symptoms were similar between male and female adolescents using multiple linear regression. In fully adjusted models, sex moderated the association between school night total sleep time and depressive symptoms (p < 0.001) and between social jetlag and depressive symptoms (p = 0.037). In females, but not in males, school night total sleep time was negatively associated with depressive symptoms (p < 0.001), whereas social jetlag (p < 0.001) was positively and independently associated with depressive symptoms. The results indicate the importance of regular sleep timing across the week and adequate sleep duration for the maintenance of optimal emotional health among female adolescents.
C1 [Mathew, Gina Marie; Chang, Anne-Marie] Penn State Univ, Coll Hlth & Human Dev, Dept Biobehav Hlth, 219 Biobehav Hlth Bldg, University Pk, PA 16802 USA.
   [Hale, Lauren] Stony Brook Med, Dept Family Populat & Prevent Med, Program Publ Hlth, Stony Brook, NY USA.
   [Chang, Anne-Marie] Penn State Univ, Coll Nursing, University Pk, PA 16802 USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE);
   Pennsylvania State University; Penn State Behrend; Pennsylvania State
   University - University Park; State University of New York (SUNY)
   System; Stony Brook University; Stony Brook University Hospital;
   Pennsylvania Commonwealth System of Higher Education (PCSHE);
   Pennsylvania State University; Penn State Behrend; Pennsylvania State
   University - University Park
RP Mathew, GM (corresponding author), Penn State Univ, Coll Hlth & Human Dev, Dept Biobehav Hlth, 219 Biobehav Hlth Bldg, University Pk, PA 16802 USA.
EM gmm42@psu.edu
OI Mathew, Gina/0000-0002-9658-7154; Chang, Anne-Marie/0000-0002-3943-416X
FU Eunice Kennedy Shriver National Institute of Child Health and Human
   Development (NICHD) of the National Institutes of Health [R01HD073352,
   R01HD36916, R01HD39135, R01HD40421]
FX The authors have indicated no financial conflicts of interest relevant
   to the current study. Dr. Lauren Hale receives an honorarium from the
   National Sleep Foundation for serving as Editor-in-Chief of the journal
   Sleep Health. Research reported in this publication was supported by the
   Eunice Kennedy Shriver National Institute of Child Health and Human
   Development (NICHD) of the National Institutes of Health under award
   numbers R01HD073352 (to LH), R01HD36916, R01HD39135, and R01HD40421, as
   well as a consortium of private foundations. The content is solely the
   responsibility of the authors and does not necessarily represent the
   official views of the National Institutes of Health.
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NR 75
TC 43
Z9 46
U1 1
U2 23
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0748-7304
EI 1552-4531
J9 J BIOL RHYTHM
JI J. Biol. Rhythms
PD APR
PY 2019
VL 34
IS 2
BP 205
EP 217
DI 10.1177/0748730419828102
PG 13
WC Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Life Sciences & Biomedicine - Other Topics; Physiology
GA HS7FF
UT WOS:000464034700008
PM 30773079
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Chen, Y
   Qian, LJ
AF Chen, Yue
   Qian, Lingjia
TI Association between lifetime stress and obesity in Canadians
SO PREVENTIVE MEDICINE
LA English
DT Article
DE Body mass index; National survey; Obesity; Stress; Woman
ID BODY-MASS INDEX; MALE JAPANESE WORKERS; EATING BEHAVIOR; JOB STRESS;
   PSYCHOSOCIAL STRESS; METABOLIC SYNDROME; MILITARY VETERANS; ABDOMINAL
   OBESITY; PHYSICAL-ACTIVITY; VISCERAL OBESITY
AB Background. Obesity has been linked to stress, but there is lack of strong evidence from general populations.
   Methods. The analysis was based on data from 112,716 Canadians aged 18 years or more who participated in a national survey conducted in 2007-2008. A questionnaire covered the information on self-perceived lifetime stress, height, and weight. Logistic regression analysis was used to determine the association between chronic stress and obesity.
   Results. The crude prevalence of obesity was 18.1% for men and 16.0% for women. A small proportion (3.7%) of the participants reported being extremely stressed most days in their lives and 19.1% reported being quite a bit stressed, and the proportions of stress were slightly higher in women than in men. Overall, those who reported being extremely stressed (adjusted OR: 1.23, 95% CI: 1.13, 135) or those who reported being quite a bit stressed (adjusted OR: 1.08, 95% CI: 1.02, 1.15) had an increased risk of obesity compared with who were not at all stressed. The adjusted odds ratio was 1.44 (95% CI: 1.13, 135) for women who were extremely stressed compared with women who were not at all stressed.
   Conclusion. Lifetime stress was associated with an increased risk of obesity especially in women. (C) 2012 Elsevier Inc. All rights reserved.
C1 [Chen, Yue] Univ Ottawa, Fac Med, Dept Epidemiol & Community Med, Ottawa, ON K1H 8M5, Canada.
   [Qian, Lingjia] Basic Med Res Inst, Beijing, Peoples R China.
C3 University of Ottawa
RP Chen, Y (corresponding author), Univ Ottawa, Fac Med, Dept Epidemiol & Community Med, 451 Smyth Rd, Ottawa, ON K1H 8M5, Canada.
EM ychen@uottawa.ca
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NR 34
TC 30
Z9 33
U1 3
U2 27
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0091-7435
EI 1096-0260
J9 PREV MED
JI Prev. Med.
PD NOV
PY 2012
VL 55
IS 5
BP 464
EP 467
DI 10.1016/j.ypmed.2012.08.013
PG 4
WC Public, Environmental & Occupational Health; Medicine, General &
   Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health; General & Internal Medicine
GA 036VT
UT WOS:000311061100023
PM 22944151
DA 2025-06-11
ER

PT J
AU Magnavita, N
   Capitanelli, I
   Garbarino, S
   Pira, E
AF Magnavita, N.
   Capitanelli, I.
   Garbarino, S.
   Pira, E.
TI Work-related stress as a cardiovascular risk factor in police officers:
   a systematic review of evidence
SO INTERNATIONAL ARCHIVES OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH
LA English
DT Review
DE Police officers; Cardiovascular disease; Cardiovascular risk factors;
   Stress; Public safety
ID CORONARY-HEART-DISEASE; EFFORT-REWARD IMBALANCE; JOB STRAIN;
   OCCUPATIONAL STRESSORS; METABOLIC SYNDROME; PERCEIVED STRESS; SWEDISH
   POLICE; BLOOD-PRESSURE; METAANALYSIS; PERSONNEL
AB Several studies suggest that work-related stress in police officers may be associated with an increased risk of cardiovascular diseases. A systematic review of studies is, however, still lacking.
   According to PRISMA statement, a systematic search of PubMed, ISI Web of Science, Cinahl and PsychInfo electronic databases was undertaken. Studies published in English between 1/1/2000 and 31/12/2016 were included. A studies quality assessment was performed using the Newcastle Ottawa scale (NOS).
   The preliminary search retrieved 752 records. After selection, 16 studies (total population 17,698) were retrieved. The average quality of studies was low. Exposure to stress in cross-sectional studies was inconstantly associated with hypertension, obesity, dyslipidaemia, and impaired glucose metabolism. In addition, there was a prevalence of positive studies showing an association between stress and cardiovascular disease morbidity. Studies of higher quality, such as longitudinal studies on large sample size, were more supportive of a significant positive association between stress and cardiovascular risk factors. Results were, however, often conflicting and inconsistent with regard to definitions and measurement of stress, features of individual study design, study conduct, and conclusions drawn.
   A sound precautionary principle would be to adopt worksite health promotion programs designed to implement stress management strategies in this category of workers.
C1 [Magnavita, N.; Capitanelli, I.] Univ Cattolica Sacro Cuore, Inst Publ Hlth, Occupat Hlth Unit, Rome, Italy.
   [Garbarino, S.] Minist Interior, State Police, Cent Hlth Serv, Rome, Italy.
   [Garbarino, S.] Univ Genoa, DINOGMI, Genoa, Italy.
   [Pira, E.] Univ Turin, Occupat Hlth, Turin, Italy.
C3 Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli;
   University of Genoa; University of Turin
RP Capitanelli, I (corresponding author), Univ Cattolica Sacro Cuore, Inst Publ Hlth, Occupat Hlth Unit, Rome, Italy.
EM ilaria.capitanelli@yahoo.it
RI Magnavita, Nicola/J-6074-2014; capitanelli, Ilaria/AAA-8808-2022;
   Garbarino, Sergio/X-5368-2018
OI Garbarino, Sergio/0000-0002-8508-552X; PIRA, Enrico/0000-0003-2754-0827
CR [Anonymous], LINEE GUIDA SORVEGLI
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NR 64
TC 68
Z9 90
U1 3
U2 28
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0340-0131
EI 1432-1246
J9 INT ARCH OCC ENV HEA
JI Int. Arch. Occup. Environ. Health
PD MAY
PY 2018
VL 91
IS 4
BP 377
EP 389
DI 10.1007/s00420-018-1290-y
PG 13
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA GD4IX
UT WOS:000430467900002
PM 29344727
DA 2025-06-11
ER

PT J
AU Lara-Hernández, F
   Melero, R
   Quiroz-Rodríguez, ME
   Moya-Valera, C
   Gallardo-Espinoza, MD
   Alvarez, L
   Valarezo-Torres, IL
   Briongos-Figuero, L
   Abadía-Otero, J
   Mena-Martin, FJ
   Saez, G
   Redon, J
   Martín-Escudero, JC
   García-García, AB
   Ayala, G
   Chaves, FJ
AF Lara-Hernandez, Francisco
   Melero, Rebeca
   Quiroz-Rodriguez, Maria Elena
   Moya-Valera, Celeste
   Gallardo-Espinoza, Mariana de Jesus
   Alvarez, Luis
   Valarezo-Torres, Ingrid Lizeth
   Briongos-Figuero, Laisa
   Abadia-Otero, Jessica
   Mena-Martin, Francisco Javier
   Saez, Guillermo
   Redon, Josep
   Martin-Escudero, Juan-Carlos
   Garcia-Garcia, Ana-Barbara
   Ayala, Guillermo
   Chaves, Felipe Javier
TI Genetic interaction between oxidative stress and body mass index in a
   Spanish population
SO REDOX BIOLOGY
LA English
DT Article
DE Body mass index; Oxidative stress; SNP; Linear regression model;
   Interaction; Lipid peroxidation
ID NF-KAPPA-B; RENIN-ANGIOTENSIN SYSTEM; TNF-ALPHA; METABOLIC SYNDROME;
   WEIGHT-LOSS; OBESITY; ADIPOSE; INFLAMMATION; POLYMORPHISMS; EXPRESSION
AB Oxidative stress may act as a contributing factor in the development of an elevated body mass index (BMI). Oxidative stress has the potential to modulate genetic activity at various levels, including gene transcription and protein function regulation. Nevertheless, the interplay between genetic variants and oxidative stress in relation to BMI remains to be elucidated. Based on this premise, we studied the potential association between 723 single- nucleotide polymorphisms (SNPs) located within a set of 212 genes and both BMI and oxidative stress parameters in 1502 adults from the general Spanish population (Hortega Study). Oxidative stress parameters measured included malondialdehyde (MDA) levels, 8-oxo-2 '-deoxyguanosine (8-oxo-dG) levels and oxidised/reduced glutathione ratio (GSSG/GSH). We also examined the potential impact of the interaction between these SNPs and oxidative stress levels on BMI. The genes selected regulate several key biological processes, including obesity, blood pressure, inflammation, lipid metabolism and redox homeostasis. Our findings indicate a robust association between specific genes and both BMI and oxidative stress parameters. Significant BMI-related interactions between genes and oxidative stress parameters were identified, which have a multifactorial impact on oxidative stress modulation and on BMI. SNPs identified in genes such as NPPA, CPT1A, DDIT3, NOX and IL6ST were significantly associated with all oxidative stress parameters analysed, indicating a substantial influence on BMI modulation. The results provide compelling evidence of a significant relationship between oxidative stress levels and genetic background. Our data provide new insights into BMI modulation by oxidative stress levels, highlighting a role for TNF as a key player in the interrelation of oxidative stress and BMI.
C1 [Lara-Hernandez, Francisco; Melero, Rebeca; Quiroz-Rodriguez, Maria Elena; Moya-Valera, Celeste; Gallardo-Espinoza, Mariana de Jesus; Alvarez, Luis; Valarezo-Torres, Ingrid Lizeth; Garcia-Garcia, Ana-Barbara; Chaves, Felipe Javier] INCLIVA Biomed Res Inst, Genom & Diabet Unit, Valencia 46010, Spain.
   [Briongos-Figuero, Laisa; Abadia-Otero, Jessica; Mena-Martin, Francisco Javier; Martin-Escudero, Juan-Carlos] Rio Hortega Univ Hosp, Internal Med Serv, Valladolid 47012, Spain.
   [Saez, Guillermo] Univ Valencia, Fac Med & Odontol, Dept Biochem & Mol Biol, Valencia 46010, Spain.
   [Saez, Guillermo] Univ Hosp Dr Peset FISABIO, Serv Clin Anal, Valencia, Spain.
   [Redon, Josep] Univ Valencia, INCLIVA Biomed Res Inst, Cardiometab Renal Risk Res Grp, Valencia 46010, Spain.
   [Redon, Josep] CIBEROBN, ISCIII, Madrid 28029, Spain.
   [Martin-Escudero, Juan-Carlos] Univ Valladolid, Dept Med, Fac Med, Valladolid 47002, Spain.
   [Garcia-Garcia, Ana-Barbara; Chaves, Felipe Javier] CIBERDEM, ISCIII, Madrid 28029, Spain.
   [Ayala, Guillermo] Univ Valencia, Dept Stat & Operat Res, Valencia 46100, Spain.
   [Alvarez, Luis] CEU Univ, Univ Cardenal Herrera CEU, Vet Med Fac, Fac Vet,Dept Anim Prod & Hlth Publ Hlth & Food Sc, Valencia, Spain.
   [Briongos-Figuero, Laisa] Hosp Santos Reyes Aranda Duero, Internal Med Serv, Burgos, Spain.
   [Briongos-Figuero, Laisa] Valladolid Univ, Med Dermatol & Toxi col Dept Valladolid, Valladolid, Spain.
C3 Hospital del Rio Hortega; University of Valencia; University of
   Valencia; Instituto de Salud Carlos III; CIBER - Centro de Investigacion
   Biomedica en Red; CIBEROBN; Universidad de Valladolid; CIBER - Centro de
   Investigacion Biomedica en Red; CIBERDEM; Instituto de Salud Carlos III;
   University of Valencia; Universidad CEU Cardenal Herrera; Universidad de
   Valladolid
RP García-García, AB (corresponding author), Menendez Pelayo 4 acc, Valencia 46010, Spain.
EM a.barbara.garcia@ext.uv.es
RI CHAVES, FELIPE/ABC-3294-2021; MARTÍN ESCUDERO, JUAN
   CARLOS/HKO-9048-2023; REDON, JOSEP/E-1719-2019; Briongos Figuero, Laisa
   Socorro/AEE-2624-2022
OI CHAVES, FELIPE J/0000-0001-8009-3689
FU Generalitat Valenciana; FISABIO [Emerging Groups-UGP-19-037]; I + D + i
   project PGC type B) [PID2020-117114GBI00 (G A)]; Ministerio de Ciencia e
   Innovacio <acute accent> [PI17/00544, PI21/00506]; Instituto de Salud
   Carlos III (ISCIII) [CIPROM/2023/066 (G A)]; CIBERDEM [CB07/08/0018];
   ISCIII - European Union (European Regional Development Fund (ERDF))
FX <STRONG> </STRONG>This work has been funded by research grants:
   "Emerging Groups-UGP-19-037" funded by FISABIO, PID2020-117114GBI00 (G
   A) (a I + D + i project PGC type B) MCIN/AEI/10.13039/501100011033/,
   PI17/00544 (F J Ch) , and PI21/00506 (F.J.Ch) , from "Ministerio de
   Ciencia e Innovacion and Instituto de Salud Carlos III (ISCIII) ", and
   CIPROM/2023/066 (G A) from Generalitat Valenciana. CIBERDEM
   (CB07/08/0018) and CIBEROBN are part of CIBER (Consorcio Centro de
   Inves-tigacio <acute accent> n Biome <acute accent> ica en Red) funded
   by ISCIII. Research projects and CIBER are co-funded by the European
   Union (European Regional Development Fund (ERDF) "A way to build
   Europe") . R.M, F.L-H, C.M-V and M -E.Q-R, are PhD-Students funded by
   grants ACIF/2020/217, ACIF/2021/229, CIACIF/2021/411 and
   GRISOLIAP/2020/039, respectively, from Generalitat Valenciana. Funders
   have no role in the design, collection, analysis, or interpretation of
   data, writing or sub-mitting the article for publication.
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NR 127
TC 1
Z9 1
U1 8
U2 8
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2213-2317
J9 REDOX BIOL
JI Redox Biol.
PD MAR
PY 2025
VL 80
AR 103531
DI 10.1016/j.redox.2025.103531
EA FEB 2025
PG 13
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA X4D3W
UT WOS:001424872700001
PM 39923398
OA gold
DA 2025-06-11
ER

PT J
AU Koponen, H
   Kautiainen, H
   Leppänen, E
   Mäntyselkä, P
   Vanhala, M
AF Koponen, Hannu
   Kautiainen, Hannu
   Leppanen, Esa
   Mantyselka, Pekka
   Vanhala, Mauno
TI Association between suicidal behaviour and impaired glucose metabolism
   in depressive disorders
SO BMC PSYCHIATRY
LA English
DT Article
DE Cholesterol; Depression; Glucose; Insulin resistance; Suicidal
   behaviour; Ideation; Suicidality; Suicide attempt; Triglyceride
ID INSULIN-RESISTANCE; SERUM-CHOLESTEROL; MENTAL-DISORDERS; KEY COMPONENT;
   INFLAMMATION; ACTIVATION; CYTOKINES; SYMPTOMS; EPIDEMIOLOGY;
   METAANALYSIS
AB Background: Disturbances in lipid metabolism have been linked to suicidal behaviour, but little is known about the association between suicide risk and abnormal glucose metabolism in depression. Hyperglycaemia and hyperinsulinaemia may increase the risk of depression and also the risk for suicide, we therefore studied associations between suicidal behaviour and disturbances in glucose metabolism in depressive patients who had been referred to depression nurse case managers.
   Methods: Patients aged 35 years and older (N = 448, mean age 51 years) who were experiencing a new depressive episode, who were referred to depression nurse case managers in 2008-2009 and who scored = 10 on the Beck Depression Inventory were enrolled in this study. The study was conducted in municipalities within the Central Finland Hospital District (catchment area of 274 000 inhabitants) as part of the Finnish Depression and Metabolic Syndrome in Adults study. The patients' psychiatric diagnoses and suicidal behaviour were confirmed by the Mini-International Neuropsychiatric Interview. Blood samples, for glucose and lipid determinations, were drawn from participants after 12 h of fasting, which was followed by a 2-hour oral glucose tolerance test (OGTT) when blood was drawn at 0 and 2 h. Insulin resistance was measured by the Quantitative Insulin Sensitivity Check Index (QUICKI) method.'
   Results: Suicidal ideation (49 %) and previous suicide attempts (16 %) were common in patients with major depressive disorder or dysthymia. Patients with depression and suicidal behaviour had higher blood glucose concentrations at baseline and at 2 hours in the OGTT. Glucose levels associated positively with the prevalence of suicidal behaviour, and the linearity was significant at baseline (p for linearity: 0.012, adjusted for age and sex) and for 2-hour OGTT glucose (p for linearity: 0.004, adjusted for age and sex). QUICKI levels associated with suicidal behavior (p for linearity across tertiles of QUICKI: 0.026). Total and LDL cholesterol and triglyceride levels were also higher in those patients with suicidal behaviour. Multivariate analysis revealed that blood glucose levels, BDI scores and antidepressive medications associated with suicidal behaviour.
   Conclusion: Insulin resistance and disturbances in glucose and lipid metabolism may be more common in middle-aged depressive patients with suicidal behaviour.
C1 [Koponen, Hannu] Univ Helsinki, Old Age Psychiat, FIN-00014 Helsinki, Finland.
   [Koponen, Hannu] Helsinki Univ Hosp, FIN-00014 Helsinki, Finland.
   [Kautiainen, Hannu; Mantyselka, Pekka; Vanhala, Mauno] Kuopio Univ Hosp, Primary Hlth Care Unit, SF-70210 Kuopio, Finland.
   [Kautiainen, Hannu; Vanhala, Mauno] Cent Hosp Cent Finland, Primary Hlth Care Unit, Jyvaskyla, Finland.
   [Leppanen, Esa] Cent Finland Hosp Dist, KESLAB, Publ Util Lab, Jyvaskyla, Finland.
   [Mantyselka, Pekka] Univ Eastern Finland, Sch Med, Inst Publ Hlth & Clin Nutr, Primary Hlth Care Unit, Kuopio, Finland.
   [Vanhala, Mauno] Univ Eastern Finland, Dept Hlth Sci, Kuopio, Finland.
C3 University of Helsinki; University of Helsinki; Helsinki University
   Central Hospital; Kuopio University Hospital; University of Eastern
   Finland; University of Eastern Finland Hospital; Central Finland Central
   Hospital; Central Finland Central Hospital; University of Eastern
   Finland; University of Eastern Finland
RP Koponen, H (corresponding author), Univ Helsinki, Old Age Psychiat, POB 22, FIN-00014 Helsinki, Finland.
EM hannu.j.koponen@hus.fi
OI Koponen, Hannu/0000-0002-7368-1869
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NR 39
TC 78
Z9 85
U1 0
U2 15
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1471-244X
J9 BMC PSYCHIATRY
JI BMC Psychiatry
PD JUL 22
PY 2015
VL 15
AR 163
DI 10.1186/s12888-015-0567-x
PG 8
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychiatry
GA CN1UB
UT WOS:000358204500001
PM 26199013
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Lan, LY
   Peng, SS
   Zhang, R
   He, HY
   Yang, Y
   Xi, B
   Zhang, JJ
AF Lan, Liuyi
   Peng, Sisi
   Zhang, Ran
   He, Haoying
   Yang, Yong
   Xi, Bing
   Zhang, Junjian
TI Serum proteomic biomarker investigation of vascular depression using
   data-independent acquisition: a pilot study
SO FRONTIERS IN AGING NEUROSCIENCE
LA English
DT Article
DE vascular depression (VaD); serum proteome; biomarkers; cerebrovascular
   disease; machine learning
ID LATE-LIFE DEPRESSION; CEREBRAL-BLOOD-FLOW; WHITE-MATTER; FTO GENE;
   MICROVASCULAR DYSFUNCTION; METABOLIC SYNDROME; FAT MASS; ASSOCIATION;
   SYMPTOMS; EPIDEMIOLOGY
AB Background Vascular depression (VaD) is a depressive disorder closely associated with cerebrovascular disease and vascular risk factors. It remains underestimated owing to challenging diagnostics and limited information regarding the pathophysiological mechanisms of VaD. The purpose of this study was to analyze the proteomic signatures and identify the potential biomarkers with diagnostic significance in VaD.Methods Deep profiling of the serum proteome of 35 patients with VaD and 36 controls was performed using liquid chromatography-tandem mass spectrometry (LC-MS/MS). Functional enrichment analysis of the quantified proteins was based on Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway, and Reactome databases. Machine learning algorithms were used to screen candidate proteins and develop a protein-based model to effectively distinguish patients with VaD.Results There were 29 up-regulated and 31 down-regulated proteins in the VaD group compared to the controls (|log2FC| >= 0.26, p <= 0.05). Enrichment pathways analyses showed that neurobiological processes related to synaptic vesicle cycle and axon guidance may be dysregulated in VaD. Extrinsic component of synaptic vesicle membrane was the most enriched term in the cellular components (CC) terms. 19 candidate proteins were filtered for further modeling. A nomogram was developed with the combination of HECT domain E3 ubiquitin protein ligase 3 (HECTD3), Nidogen-2 (NID2), FTO alpha-ketoglutarate-dependent dioxygenase (FTO), Golgi membrane protein 1 (GOLM1), and N-acetylneuraminate lyase (NPL), which could be used to predict VaD risk with favorable efficacy.Conclusion This study offers a comprehensive and integrated view of serum proteomics and contributes to a valuable proteomics-based diagnostic model for VaD.
C1 [Lan, Liuyi; Zhang, Ran; He, Haoying; Zhang, Junjian] Wuhan Univ, Zhongnan Hosp, Dept Neurol, Wuhan, Peoples R China.
   [Peng, Sisi] Wuhan Univ, Dept Neuropsychol, Zhongnan Hosp, Wuhan, Peoples R China.
   [Yang, Yong; Xi, Bing] SpecAlly Life Technol Co Ltd, Wuhan, Peoples R China.
C3 Wuhan University; Wuhan University
RP Zhang, JJ (corresponding author), Wuhan Univ, Zhongnan Hosp, Dept Neurol, Wuhan, Peoples R China.
EM zhangjj@whu.edu.cn
FU Medical Science and Technology Innovation Platform Support Project;
   Zhongnan Hospital of Wuhan University;  [PTXM2020006]
FX We express our appreciation to the investigators in the cohort study of
   vascular depression in the Department of Neurology, Zhongnan Hospital of
   Wuhan University. We sincerely appreciate the support of Zhongnan
   Hospital of Wuhan University with the funding of: the Medical Science
   and Technology Innovation Platform Support Project (PTXM2020006).
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NR 78
TC 3
Z9 3
U1 1
U2 5
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1663-4365
J9 FRONT AGING NEUROSCI
JI Front. Aging Neurosci.
PD FEB 7
PY 2024
VL 16
AR 1341374
DI 10.3389/fnagi.2024.1341374
PG 13
WC Geriatrics & Gerontology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology; Neurosciences & Neurology
GA IG1Q5
UT WOS:001165089000001
PM 38384936
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Chang, NC
   Dai, CY
   Lin, WY
   Yang, HL
   Wang, HM
   Chien, CY
   Ho, KY
AF Chang, Ning Chia
   Dai, Chia Yen
   Lin, Wen Yi
   Yang, Hua Ling
   Wang, Hsun Mo
   Chien, Chen Yu
   Ho, Kuen Yao
TI Prevalence of Persistent Tinnitus and Dizziness in an Elderly Population
   in Southern Taiwan
SO JOURNAL OF INTERNATIONAL ADVANCED OTOLOGY
LA English
DT Article; Proceedings Paper
CT 30th Congress of the Barany-Society
CY JUN 10-13, 2018
CL Uppsala, SWEDEN
SP Barany Soc
DE Dizziness; elderly; metabolic syndrome; prevalence; tinnitus
ID COMMUNITY; EPIDEMIOLOGY; SYMPTOMS; HEALTH; DETERMINANTS; ASSOCIATION
AB OBJECTIVES: Tinnitus and dizziness are common among the elderly. The conditions may increase depression, and patients may become susceptible to falls, thereby affecting the quality of life of the geriatric population. Investigating the prevalence of persistent tinnitus and chronic/recurrent dizziness in an elderly population and analyzing the association of certain comorbidities with tinnitus and dizziness in southern Taiwan were the main purposes of this study.
   MATERIALS and METHODS: This was a cross-sectional study performed in a metropolitan hospital. Hearing tests were conducted in a total of 597 volunteers aged >= 65 years involving 322 (53.9%) men and 275 (46.1%) women recruited in the study. The pure tone average (PTA) and hearing handicap (HH) score were calculated. Patients completed questionnaires regarding the history of hypertension and diabetes and symptoms of tinnitus and dizziness. The association of gender, age, PTA/HH, body mass index (BMI), hypertension, diabetes, and metabolic syndrome (MetS) with tinnitus and dizziness were analyzed.
   RESULTS: The prevalence of persistent tinnitus and chronic/recurrent dizziness was 32.0% and 24.1%, respectively. Tinnitus or dizziness were not associated with age, BMI, hypertension, diabetes, and MetS but was associated with hearing impairment. Women and those with fasting glucose levels <100 mg/dL were more likely to experience dizziness.
   CONCLUSION: Persistent tinnitus and dizziness were common in an elderly population in southern Taiwan. These findings may help develop strategies to promote the quality of life in the elderly population.
C1 [Chang, Ning Chia; Dai, Chia Yen; Ho, Kuen Yao] Kaohsiung Med Univ, Sch Med, Dept Otorhinolaryngol, Kaohsiung, Taiwan.
   [Wang, Hsun Mo] Kaohsiung Municipal Hsiaokang Hosp, Dept Otorhinolaryngol, Kaohsiung, Taiwan.
   [Chang, Ning Chia; Lin, Wen Yi] Kaohsiung Municipal Hsiaokang Hosp, Hlth Management Ctr, Kaohsiung, Taiwan.
   [Chien, Chen Yu] Kaohsiung Med Univ, Sch Med, Dept Internal Med, Kaohsiung, Taiwan.
   [Dai, Chia Yen; Yang, Hua Ling] Kaohsiung Med Univ Hosp, Sch Med, Div Hepatobiliary & Pancreat Med, Dept Internal Med, Kaohsiung, Taiwan.
   [Chien, Chen Yu; Ho, Kuen Yao] Kaohsiung Med Univ Hosp, Dept Otorhinolaryngol, Kaohsiung, Taiwan.
C3 Kaohsiung Medical University; Kaohsiung Medical University; Kaohsiung
   Municipal Siao-Gang Hospital; Kaohsiung Medical University; Kaohsiung
   Municipal Siao-Gang Hospital; Kaohsiung Medical University; Kaohsiung
   Medical University; Kaohsiung Medical University Hospital; Kaohsiung
   Medical University; Kaohsiung Medical University Hospital
RP Ho, KY (corresponding author), Kaohsiung Med Univ, Sch Med, Dept Otorhinolaryngol, Kaohsiung, Taiwan.; Ho, KY (corresponding author), Kaohsiung Med Univ Hosp, Dept Otorhinolaryngol, Kaohsiung, Taiwan.
EM 890098@kmuh.org.tw
RI Huang, Yi-Hsiang/ADX-9119-2022; CHIEN, CHEN-YU/HME-0129-2023; Dai,
   Chia-Yen/V-6560-2019; Ho, Kuen-Yao/D-5177-2009
FU Training and Research Center of Kaohsiung Municipal Hsiao-Kang Hospital
   [kmhk-105-004]
FX This study was supported by Training and Research Center of Kaohsiung
   Municipal Hsiao-Kang Hospital (Grant No: kmhk-105-004).
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Z9 25
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U2 7
PU AVES
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EI 2148-3817
J9 J INT ADV OTOL
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IS 1
BP 99
EP 105
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WC Otorhinolaryngology
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Otorhinolaryngology
GA HU7LX
UT WOS:000465464000019
PM 31058599
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Sun, XY
   Zhang, ZA
   Ren, JY
   Pei, HT
   Liu, J
   Yin, BW
   Zhang, CY
   Wen, R
   Qiao, SM
   Wang, ZY
   Ma, YX
AF Sun, Xiaoya
   Zhang, Zhenao
   Ren, Jingyi
   Pei, Huanting
   Liu, Jie
   Yin, Bowen
   Zhang, Chongyue
   Wen, Rui
   Qiao, Simeng
   Wang, Ziyi
   Ma, Yuxia
TI Association Between Volatile Organic Compounds and Circadian Syndrome
   Among Pre- and Postmenopausal Women
SO TOXICS
LA English
DT Article
DE volatile organic compounds; circadian syndrome; premenopausal;
   postmenopausal; NHANES
ID LIPID-PEROXIDATION; INSULIN-RESISTANCE; METABOLIC SYNDROME; DEPRESSION;
   EXPOSURE; CLOCK
AB Air pollution is closely associated with the development of multiple metabolic diseases. Circadian syndrome (CircS), as an extended concept of metabolic syndrome (MetS), has been proven to be a better predictor of metabolic diseases than MetS. However, the relationship between volatile organic compounds (VOCs) and CircS in pre- and postmenopausal women remains unclear. This study used data from the National Health and Nutrition Examination Survey (NHANES) 2011-2020, including 520 premenopausal women and 531 postmenopausal women. Generalized linear model (GLM), restricted cubic spline (RCS) model, subgroup analyses, and weighted quantile sum (WQS) model were used to assess the relationship between VOCs and CircS. In addition, sensitivity analyses were performed to evaluate the robustness of the results. Our findings showed that seven VOC metabolites were positively associated with the risk of CircS in postmenopausal women. In premenopausal women, only two VOC metabolites were positively associated with the risk of CircS. The WQS analysis further confirmed that VOC mixtures selected by a least absolute shrinkage and selection operator (LASSO) were significantly associated with an increased risk of CircS in postmenopausal women, with HPMMA identified as the primary contributor to the combined effect. This association was not evident in premenopausal women. Meanwhile, in postmenopausal women, individual urinary VOC metabolites and VOC mixtures were observed to be positively associated with elevated glucose and short sleep. Our results highlighted that VOC exposure was strongly associated with the occurrence of CircS in postmenopausal women. Further research is needed to confirm this conclusion.
C1 [Sun, Xiaoya; Zhang, Zhenao; Ren, Jingyi; Pei, Huanting; Liu, Jie; Yin, Bowen; Zhang, Chongyue; Wen, Rui; Qiao, Simeng; Wang, Ziyi; Ma, Yuxia] Hebei Med Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Hebei Key Lab Environm & Human Hlth, Shijiazhuang 050017, Peoples R China.
C3 Hebei Medical University
RP Ma, YX (corresponding author), Hebei Med Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Hebei Key Lab Environm & Human Hlth, Shijiazhuang 050017, Peoples R China.
EM mayuxia@hebmu.edu.cn
FU National Natural Science Foundation of China;  [82373558]
FX Our research was funded by the National Natural Science Foundation of
   China (No. 82373558).
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NR 69
TC 0
Z9 0
U1 0
U2 0
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2305-6304
J9 TOXICS
JI Toxics
PD APR 23
PY 2025
VL 13
IS 5
AR 328
DI 10.3390/toxics13050328
PG 17
WC Environmental Sciences; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Toxicology
GA 3AC5O
UT WOS:001495440100001
PM 40423407
OA gold
DA 2025-06-11
ER

PT J
AU Huang, SS
   Lin, CH
   Chan, CH
   Loh, EW
   Lan, TH
AF Huang, Shiau-Shian
   Lin, Ching-Heng
   Chan, Chin-Hong
   Loh, El-Wui
   Lan, Tsuo-Hung
TI Newly diagnosed major depressive disorder and the risk of erectile
   dysfunction: A population-based cohort study in Taiwan
SO PSYCHIATRY RESEARCH
LA English
DT Article
DE Antidepressants; Erectile dysfunction; Untreated depression; Major
   depressive disorder
ID INDUCED SEXUAL DYSFUNCTION; METABOLIC SYNDROME; SYMPTOMS; ASSOCIATION;
   SERTRALINE; MEN; EPIDEMIOLOGY; OUTPATIENTS; PREVALENCE; EFFICACY
AB Introduction: The primary aim of this study was to explore the incidence rate of erectile dysfunction (ED) among major depressive disorder (MDD) patients in an Asian country. The second aim was to compare the risk of ED in MDD patients that were treated using antidepressants with a high risk-ED, antidepressants with a low risk-ED, or without treatment.
   Methods: We identified 4339 male patients with newly diagnosed MDD using the National Health Database. Four matched controls per case were selected for the study.
   Results: The mean age of the participants was 42.3 +/- 16.9. A higher crude HR of 3.6 (95% CI: 2.8-4.6) was seen in the male patients with MDD. After adjusting for obesity, monthly income, urbanization level, and comorbidity, the MDD patients had a 3.2-fold higher HR for an ED diagnosis than the controls. Patients with untreated depression had the highest risk of ED, compared to the control group (HR=3.9). Patients treated with IHiRA had a medium risk of developing ED (HR=3.6), and patients treated with ILoRA had the lowest risk of ED (HR: 2.5).
   Conclusion: This prospective cohort study found an association between ED and prior MDD. Patients with untreated depression may have the highest risk of developing ED. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
C1 [Huang, Shiau-Shian; Chan, Chin-Hong; Lan, Tsuo-Hung] Taichung Vet Gen Hosp, Dept Psychiat, Taichung, Taiwan.
   [Lin, Ching-Heng] Taichung Vet Gen Hosp, Dept Med Res, Taichung, Taiwan.
   [Loh, El-Wui] Kaohsiung Municipal Kai Syuan Psychiat Hosp, Kaohsiung, Taiwan.
   [Lan, Tsuo-Hung] Natl Yang Ming Univ, Sch Med, Taipei 112, Taiwan.
   [Lan, Tsuo-Hung] Natl Hlth Res Inst, Taipei, Taiwan.
C3 Taichung Veterans General Hospital; Taichung Veterans General Hospital;
   National Yang Ming Chiao Tung University; National Health Research
   Institutes - Taiwan
RP Lan, TH (corresponding author), 160,Sec 3,Chung Kang Rd, Taichung 40705, Taiwan.
EM tosafish@hotmail.com
RI Lin, Chih-Cheng/IQT-4912-2023; Loh, El-Wui/ABD-6129-2020
OI Huang, Shiau-Shian/0000-0001-8647-1871; Lan,
   Tsuo-Hung/0000-0002-2796-1026
FU Biostatistics Task Force of Taichung Veterans General Hospital
FX The statistical analysis is supported by the Biostatistics Task Force of
   Taichung Veterans General Hospital. This study is based, in part, on
   data obtained from NHIRD that were provided by the Bureau of National
   Health Insurance of the Department of Health and managed by National
   Health Research Institutes (registration #A101095). The interpretation
   and conclusions contained herein do not represent those of the Bureau of
   National Health Insurance, Department of Health, or National Health
   Research Institutes.
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NR 40
TC 17
Z9 18
U1 0
U2 10
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0165-1781
J9 PSYCHIAT RES
JI Psychiatry Res.
PD DEC 15
PY 2013
VL 210
IS 2
BP 601
EP 606
DI 10.1016/j.psychres.2013.06.012
PG 6
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 273EU
UT WOS:000328518600037
PM 23850431
DA 2025-06-11
ER

PT J
AU Khan, UI
   Khan, SF
   Qureshi, A
AF Khan, Unab I.
   Khan, Sonya F.
   Qureshi, Asra
TI Prevalence of metabolic syndrome and its association with cardiovascular
   disease risk and common risk factors amongst healthcare workers in
   Pakistan
SO PLOS GLOBAL PUBLIC HEALTH
LA English
DT Article
ID AMERICAN-HEART-ASSOCIATION; DEPRESSION; PREDICTION; PHYSICIANS; SMOKING
AB Metabolic syndrome (MetS) significantly increases the risk of cardiovascular disease (CVD). Healthcare workers (HCWs) are at a higher risk of CVD. However, little is known about the association between MetS and CVD risk in healthcare workers in Pakistan. We aimed to assess the prevalence of MetS and its components and examined the association between MetS and 10-year CVD-risk using Framingham Risk Score (FRS) and common CVD risk factors amongst HCWs working in a private healthcare system in Pakistan. This cross-sectional study uses baseline data from an existing CVD risk screening program for employees at a private healthcare system in Pakistan. MetS was diagnosed using the American Heart Association cut-offs for Asian population. Healthcare workers were divided into MetS positive and negative groups; demographics, MetS components and CVD risk were compared between these groups. Logistic regression was used to examine the association of MetS with 10-year CVD-risk and its risk factors. In 1,807 healthcare workers, 677 (37%) had MetS and 48 (2.7%) had a high 10-year CVD-risk. Of the MetS components, low High-density Lipoprotein (HDL) 1,467 (81%) and elevated waist circumference (WC) 1,049 (58%) were the most prevalent. Compared to MetS negative group, MetS positive group had a higher proportion of high-risk CVD (0.7% vs. 5.9%; p: <0.01). After controlling for known risk factors, we found that the odds of having MetS is 5.7 times higher (aOR: 5.67 (95% CI: 2.39-13.4) in those with high CVD risk. In addition, we found a significant association between screening positive for depression and MetS (OR: 2.42 (95% CI: 1.24-4.72). Interestingly, tobacco use was not significantly associated with MetS (OR: 0.81 (95% CI: 0.58-1.15). We found a high prevalence of MetS amongst Pakistani healthcare workers and of the MetS components, low HDL and elevated WC were the most prevalent. Along with biologic risk factors (age, sex and family history of CVD), depression significantly increases the odds of having MetS. In addition, both intermediate and high CVD risk groups have significant association with MetS. Comprehensive, workplace based screening and management programs are required for HCWs to mitigate the risk of MetS and cardiovascular disease. Early identification and treatment of these risk factors may be cost-effective in lowering MetS burden in low-middle income countries.
C1 [Khan, Unab I.; Qureshi, Asra] Aga Khan Univ Hosp, Dept Family Med, Karachi, Sindh, Pakistan.
   [Khan, Sonya F.] Ziauddin Univ, Dept Family Med, Karachi, Sindh, Pakistan.
C3 Aga Khan University; Ziauddin University
RP Khan, UI (corresponding author), Aga Khan Univ Hosp, Dept Family Med, Karachi, Sindh, Pakistan.
EM unab.khan@aku.edu
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NR 27
TC 0
Z9 0
U1 0
U2 0
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
EI 2767-3375
J9 PLOS GLOB PUBL HLTH
JI PLOS Glob. Public Health
PD MAR 3
PY 2025
VL 5
IS 3
AR e0004135
DI 10.1371/journal.pgph.0004135
PG 9
WC Public, Environmental & Occupational Health
WE Emerging Sources Citation Index (ESCI)
SC Public, Environmental & Occupational Health
GA 1DH1D
UT WOS:001462289300001
PM 40029896
OA gold
DA 2025-06-11
ER

PT J
AU Cicero, AFG
   Sahebkar, A
   Fogacci, F
   Bove, M
   Giovannini, M
   Borghi, C
AF Cicero, Arrigo F. G.
   Sahebkar, Amirhossein
   Fogacci, Federica
   Bove, Marilisa
   Giovannini, Marina
   Borghi, Claudio
TI Effects of phytosomal curcumin on anthropometric parameters, insulin
   resistance, cortisolemia and non-alcoholic fatty liver disease indices:
   a double-blind, placebo-controlled clinical trial
SO EUROPEAN JOURNAL OF NUTRITION
LA English
DT Article
DE Curcumin; Phosphatidylserine; NAFLD; Diabetes; Metabolic syndrome;
   Clinical trial
ID METABOLIC SYNDROME; OBESITY; BIOAVAILABILITY; DYSREGULATION; DEPRESSION;
   BIOMARKERS; DIETARY
AB Purpose Curcumin has shown to exert a positive impact on human glucose metabolism, even if its bioavailability is usually very low. The present study aimed to explore the effect of phosphatidylserine- and piperine-containing curcumin phytosomes on a large number of metabolic parameters related to insulin resistance, in the context of a randomized double-blind placebo-controlled trial involving 80 overweight subjects with suboptimal fasting plasma glucose. Methods Subjects were randomized to be treated with indistinguishable tablets (2 per day, to be taken after dinner) containing 800 mg phytosomal curcumin (Curserin (R): 200 mg curcumin, 120 mg phosphatidylserine, 480 mg phosphatidylcholine and 8 mg piperine from Piper nigrum L. dry extract) for 8 weeks. Results After 56-day treatment, the curcumin-treated group experienced a significant improvement in fasting plasma insulin (FPI), HOMA index, waist circumference, blood pressure, triglycerides (TG), HDL-C, liver transaminases, gamma-GT, index of liver steatosis and serum cortisol compared to the baseline. FPI, TG, liver transaminases, fatty liver index and serum cortisol level also significantly improved compared with the placebo-treated group. Compared to the baseline, at the end of the study placebo group experienced an improvement only in FPG and TG. Conclusion In conclusion, the present trial shows that supplementation with a phytosomal preparation of curcumin containing phosphatidylserine and piperine could improve glycemic factors, hepatic function and serum cortisol levels in subjects with overweight and impaired fasting glucose.
C1 [Cicero, Arrigo F. G.; Fogacci, Federica; Bove, Marilisa; Giovannini, Marina; Borghi, Claudio] Univ Bologna, St Orsola Malpighi Hosp, Med & Surg Sci Dept, Atherosclerosis Res Unit, Via Albertoni 15, I-40138 Bologna, Italy.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Biotechnol Res Ctr, Pharmaceut Technol Inst, Mashhad, Razavi Khorasan, Iran.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Neurogen Inflammat Res Ctr, Mashhad, Razavi Khorasan, Iran.
C3 IRCCS Azienda Ospedaliero-Universitaria di Bologna; University of
   Bologna; Mashhad University of Medical Sciences; Mashhad University of
   Medical Sciences
RP Cicero, AFG (corresponding author), Univ Bologna, St Orsola Malpighi Hosp, Med & Surg Sci Dept, Atherosclerosis Res Unit, Via Albertoni 15, I-40138 Bologna, Italy.
EM arrigo.cicero@unibo.it
RI Sahebkar, Amirhossein/B-5124-2018; Giovannini, Marina/ITV-5674-2023;
   Cicero, Arrigo/H-8244-2019; Fogacci, Federica/R-5931-2016
OI Fogacci, Federica/0000-0001-7853-0042; Cicero, Arrigo Francesco
   Giuseppe/0000-0002-4367-3884
FU Universit? di Bologna [RFO2017] Funding Source: Medline
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NR 41
TC 152
Z9 154
U1 5
U2 32
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1436-6207
EI 1436-6215
J9 EUR J NUTR
JI Eur. J. Nutr.
PD MAR
PY 2020
VL 59
IS 2
BP 477
EP 483
DI 10.1007/s00394-019-01916-7
PG 7
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA KS7LG
UT WOS:000518487600005
PM 30796508
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Slachtová, L
   Kaminská, D
   Chvál, M
   Králík, L
   Martásek, P
   Papezová, H
AF Slachtova, L.
   Kaminska, D.
   Chval, M.
   Kralik, L.
   Martasek, P.
   Papezova, H.
TI Stress Perception and (GT)n Repeat Polymorphism in Haem Oxygenase 1
   Promoter Are Both Risk Factors in Development of Eating Disorders
SO FOLIA BIOLOGICA
LA English
DT Article
ID MICROSATELLITE POLYMORPHISM; ANOREXIA-NERVOSA; GENE PROMOTER;
   EXAMINATION-QUESTIONNAIRE; METABOLIC SYNDROME; CARBON-MONOXIDE;
   SUSCEPTIBILITY; INHIBITION; MECHANISMS; BILIRUBIN
AB Haem oxygenase 1 (110-1) plays a pivotal role in metabolic stress protecting cells in dependence on reactive oxygen species. This study investigated a potential gene environment interaction between the (GT)n repeat H01 polymorphism and the stress perception in patients with eating disorder and in controls. Stress perception and (GT)n polymorphism were measured in 127 patients with eating disorders and in 78 healthy controls using Stress and Coping Inventory and genotyping. Based on the inventory, overall, specific and weighted stress scores were defined. Clinical stress score was generated according to the patient's history and interviews. According to our hypothesis, 1) all stress scores describing subjective stress perception were significantly higher in patients compared to controls (P < 0.001; P 5_ 0.002; P 5. 0.001), 2) the L/L genotype of GT promoter repeats (L > 25 GT repeats, S < 25 GT repeats) in the patients was associated with higher overall (P < 0.001), specific (P 0.010) and weighted stress score (P < 0.005) compared to the L/S variant, and 3) Pearson's correlation of clinical versus objective stress scores showed not very tight relationship (0.198; 0.287; 0.224, respectively). We assume potential risk of the L allele of H01 promoter polymorphism for the stress response and contribution of the subjective stress perception together with the L/L genotype to the development of eating disorder. Decreased HO1 expression in the presence of L/L genotype plus more intensive stress perception in the patients can lead to secondary stress, with increasing severity of the symptoms and aggravation of the disease.
C1 [Slachtova, L.; Kralik, L.; Martasek, P.] Charles Univ Prague, Fac Med & Surg 1, Dept Paediat & Adolescent Med, Prague 12808 2, Czech Republic.
   [Kaminska, D.; Papezova, H.] Charles Univ Prague, Fac Med & Surg 1, Dept Psychiat, Prague 12808 2, Czech Republic.
   [Kaminska, D.; Papezova, H.] Gen Univ Hosp, Prague, Czech Republic.
   [Chval, M.] Charles Univ Prague, Fac Educ, Inst Res & Dev Educ, Prague 12808 2, Czech Republic.
C3 Charles University Prague; Charles University Prague; General University
   Hospital Prague; Charles University Prague
RP Martásek, P (corresponding author), Charles Univ Prague, Fac Med & Surg 1, Dept Paediat & Adolescent Med, Ke Karlovu 2, Prague 12808 2, Czech Republic.
EM pavel.martasek@gmail.com
RI Slachtova, Lenka/A-1770-2013; Chval, Martin/JGM-1085-2023; Martasek,
   Pavel/G-6622-2017; Kralik, Lubomir/D-2390-2017
OI Chval, Martin/0000-0001-8027-8907; Martasek, Pavel/0000-0001-6165-4444;
   Kralik, Lubomir/0000-0003-1428-5433; Kaminska,
   Deborah/0000-0002-9256-1117
FU Ministry of Health of the Czech Republic [IGA NT 14094/3,
   RVOVFN64165/2012]; Research programme [PRVOUK P24/LF1/3, PRVOUK
   P24/LF1/3 and P26/LF1/4, MSM 0021620849 (MSMT)]; Charles University in
   Prague, Czech Republic [UNCE 204011]
FX This study was supported by grants IGA NT 14094/3 and RVOVFN64165/2012
   from the Ministry of Health of the Czech Republic, Research programme
   MSM 0021620849 (MSMT), PRVOUK P24/LF1/3 and P26/LF1/4, UNCE 204011 from
   Charles University in Prague, Czech Republic.
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NR 54
TC 0
Z9 0
U1 0
U2 4
PU CHARLES UNIV PRAGUE, FIRST FACULTY MEDICINE
PI PRAGUE 6
PA FLEMINGOVO NAM. 2, PRAGUE 6 166 37, CZECH REPUBLIC
SN 0015-5500
J9 FOLIA BIOL-PRAGUE
JI Folia Biol.-Prague
PY 2013
VL 59
IS 6
BP 233
EP 239
PG 7
WC Biochemistry & Molecular Biology; Biology; Oncology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Oncology; Cell Biology
GA 296CB
UT WOS:000330161600004
PM 24485305
DA 2025-06-11
ER

PT J
AU Toussirot, E
   Aubin, F
   Dumoulin, G
AF Toussirot, Eric
   Aubin, Francois
   Dumoulin, Gilles
TI Relationships between adipose tissue and psoriasis, with or without
   arthritis
SO FRONTIERS IN IMMUNOLOGY
LA English
DT Review
DE obesity; psoriasis; psoriatic arthritis; cardiovascular risk; adipokines
ID BODY-MASS INDEX; CHRONIC PLAQUE PSORIASIS; MINIMAL DISEASE-ACTIVITY;
   MYOCARDIAL-INFARCTION; INCREASED PREVALENCE; GENERAL-POPULATION;
   METABOLIC SYNDROME; SERUM LEPTIN; RISK-FACTORS; OBESITY
AB Psoriasis (Pso) is a common chronic cutaneous inflammatory disease involving the skin that is associated with serious comorbidities. Comorbidities in Pso include psoriatic arthritis (PsA), reduced quality of life, malignancy, depression, but also a constellation of associated conditions that enhance the cardiovascular (CV) risk. Indeed, obesity is common in patients with Pso or PsA and is considered to be a risk factor for the onset of these diseases. Patients with Pso and PsA share common obesity-related complications such as metabolic syndrome (MetS), dyslipidemia, diabetes or insulin resistance, and CV diseases. Chronic inflammation in Pso and PsA partially explains the development of atherosclerosis and CV diseases. In parallel, body composition is disturbed in patients with Pso or PsA, as suggested by anthropometric measurements, while an excess of abdominal adiposity is observed in PsA, enhancing the risk of MetS and CV diseases. Adipokines may link the adipose tissue to the obesity-related complications of Pso and PsA. Indeed, altered circulating levels of the adipokines leptin, adiponectin, visfatine, and resistin have been found in patients with Pso or PsA. In addition, an excess of adipose tissue may compromise the therapeutic response to traditional drugs or biological agents in Pso and PsA. This paper reviews the comorbidities that contribute to enhanced CV risk, the body composition results, and the potential role of adipokines in systemic inflammation and energetic balance in Pso and PsA.
C1 [Toussirot, Eric] Univ Hosp Besancon, INSERM, Clin Invest Ctr Biotherapy, CIC 1431, F-25000 Besancon, France.
   [Toussirot, Eric] Univ Hosp Besancon, Dept Rheumatol, F-25000 Besancon, France.
   [Toussirot, Eric] Univ Franche Comte, Dept Therapeut, F-25030 Besancon, France.
   [Toussirot, Eric] Univ Franche Comte, UPRES EA Pathogens & Inflammat, F-25030 Besancon, France.
   [Toussirot, Eric] LabEX LipSTIC, ANR 11, LABX 0021, Besancon, France.
   [Aubin, Francois] Univ Hosp Besancon, Dept Dermatol, Besancon, France.
   [Aubin, Francois] Univ Franche Comte, F-25030 Besancon, France.
   [Dumoulin, Gilles] Univ Hosp Besancon, Endocrine & Metab Biochem, Besancon, France.
   [Dumoulin, Gilles] Univ Franche Comte, UPRES EA Cardiovasc Pathophysiol & Prev 3920, F-25030 Besancon, France.
C3 Universite de Franche-Comte; CHU Besancon; Institut National de la Sante
   et de la Recherche Medicale (Inserm); Universite de Franche-Comte; CHU
   Besancon; Universite de Franche-Comte; Universite de Franche-Comte;
   Universite de Franche-Comte; CHU Besancon; Universite de Franche-Comte;
   Universite de Franche-Comte; CHU Besancon; Universite de Franche-Comte
RP Toussirot, E (corresponding author), Univ Hosp Besancon, INSERM, Clin Invest Ctr Biotherapy, CIC 1431, Pl St Jacques, F-25000 Besancon, France.
EM etoussirot@chu-besancon.fr
RI Aubin, François/ABE-1236-2021
OI Aubin, Francois/0000-0002-1421-4996
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NR 56
TC 72
Z9 75
U1 0
U2 13
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-3224
J9 FRONT IMMUNOL
JI Front. Immunol.
PD AUG 12
PY 2014
VL 5
AR 368
DI 10.3389/fimmu.2014.00368
PG 7
WC Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology
GA CH9ZM
UT WOS:000354395300001
PM 25161652
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Constantino, JL
   Godschalk, M
   van Dalfsen, JH
   Veraart, JKE
   Spijker, J
   van Exel, E
   Schoevers, RA
   Kamphuis, J
AF Constantino, Juliana Lima
   Godschalk, Martijn
   van Dalfsen, Jens H.
   Veraart, Jolien K. E.
   Spijker, Jan
   van Exel, Eric
   Schoevers, Robert A.
   Kamphuis, Jeanine
TI Demographic and clinical predictors of response and remission in the
   treatment of major depressive disorder with ketamine and esketamine: A
   systematic review
SO PSYCHIATRY RESEARCH
LA English
DT Review
DE Ketamine; Esketamine; Major depressive disorder; Treatment-resistant
   depression; Systematic review
ID TREATMENT-RESISTANT DEPRESSION; ELECTROCONVULSIVE-THERAPY;
   ANTIDEPRESSANT RESPONSE; INTRANASAL ESKETAMINE; INTRAVENOUS KETAMINE;
   EFFICACY; METAANALYSIS; ASSOCIATION; MANAGEMENT; INFUSION
AB Accumulating evidence supports the efficacy of (es)ketamine in the treatment of major depressive disorder (MDD), particularly treatment-resistant depression (TRD). Yet around 50% of the individuals with TRD do not respond to (es)ketamine. Elucidating predictors of response and remission could improve treatment outcomes at the individual level by defining subpopulations that are most likely to benefit from (es)ketamine. This systematic review outlines the predictive value of demographic and clinical characteristics for treatment outcomes of (es) ketamine in MDD. A systematic literature search was performed to retrieve studies investigating the association between baseline characteristics and the likelihood of achieving response and remission following (es)ketamine treatment in MDD. Forty-four studies investigating the association between response and remission and demographic variables, characteristics of the depressive episode, treatment resistance, psychiatric comorbidities, symptomatology, suicidal risk/attempts, family/personal history, medication use, somatic variables, personality traits, and neurocognitive performance were included. The predictive value of demographic and clinical variables for treatment outcomes of (es)ketamine was limited with either no significant relationship or inconsistent results. Findings provide preliminary support for a positive association of response with anhedonia, sleep disturbances, childhood physical abuse, obesity, openness, better episodic memory, and visual learning, poorer neurocognitive performance, slower processing speed, and lower attention, as well as a negative association with melancholic depression, benzodiazepine use, and metabolic syndrome. However, these characteristics have been investigated in a limited number of studies and warrant replication. These findings suggest that (es)ketamine represents a promising treatment prospect for individuals who present clinical characteristics that are often considered difficult to treat.
C1 [Constantino, Juliana Lima; Godschalk, Martijn; van Dalfsen, Jens H.; Veraart, Jolien K. E.; Schoevers, Robert A.; Kamphuis, Jeanine] Univ Med Ctr Groningen, Dept Psychiat, Hanzepl 1, NL-9713 RB Groningen, Netherlands.
   [Veraart, Jolien K. E.] Parnassia Grp, PsyQ, The Hague, Netherlands.
   [Spijker, Jan] Pro Persona Mental Hlth Care, Depress Expertise Ctr, Nijmegen, Netherlands.
   [van Exel, Eric] Amsterdam Univ Med Ctr, Dept Psychiat, Amsterdam, Netherlands.
C3 University of Groningen; Parnassia Psychiatric Institute
RP Constantino, JL (corresponding author), Univ Med Ctr Groningen, Dept Psychiat, Hanzepl 1, NL-9713 RB Groningen, Netherlands.
EM j.lima.constantino@umcg.nl
RI van Dalfsen, Jens/AAQ-9864-2020
OI van Dalfsen, Jens H./0000-0002-4388-8447; Veraart,
   Jolien/0000-0002-9075-4804; Lima Constantino,
   Juliana/0000-0002-1889-7341; Schoevers, Robert A/0000-0003-0760-9866;
   Spijker, Jan/0000-0003-1480-9647
FU Health Holland Top Sector Life Sciences & Health Top Consortia for
   Knowledge and Innovations (TKI) [LSHM22041]
FX The writing of this systematic review was funded by a research grant
   from Health Holland Top Sector Life Sciences & Health Top Consortia for
   Knowledge and Innovations (TKI) (Grant number: LSHM22041) .
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NR 80
TC 1
Z9 1
U1 1
U2 1
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0165-1781
EI 1872-7123
J9 PSYCHIAT RES
JI Psychiatry Res.
PD MAR
PY 2025
VL 345
AR 116355
DI 10.1016/j.psychres.2025.116355
EA JAN 2025
PG 13
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA S8V9M
UT WOS:001400942600001
PM 39813859
OA hybrid
DA 2025-06-11
ER

PT J
AU Eslick, GD
   Jones, MP
   Talley, NJ
AF Eslick, GD
   Jones, MP
   Talley, NJ
TI Non-cardiac chest pain: prevalence, risk factors, impact and consulting
   - a population-based study
SO ALIMENTARY PHARMACOLOGY & THERAPEUTICS
LA English
DT Article
ID ISCHEMIC-HEART-DISEASE; NORMAL CORONARY-ARTERIES; QUALITY-OF-LIFE;
   TERM-FOLLOW-UP; GASTROESOPHAGEAL-REFLUX; ANGINA-PECTORIS; HEALTH SURVEY;
   SYNDROME-X; QUESTIONNAIRE; DIAGNOSES
AB Background: Little is known about the prevalence and importance of non-cardiac chest pain in the general population.
   Aim: To evaluate the magnitude and impact of this condition.
   Methods: A validated self-report questionnaire was mailed to a sample of 1000 residents of Penrith, selected randomly from the electoral rolls. Symptoms, risk factors, psychological distress, quality of life and demographics were measured.
   Results: The response rate was 73% (n = 672; mean age, 46 years; 52% female). Chest pain ever was reported by 39% of the population; 7% reported a history of myocardial infarction and 8% a history of angina. Two hundred and nineteen (33%) cases were classified as non-cardiac chest pain; only 23% had consulted a physician about chest pain in the previous year. The only independent risk factor for non-cardiac chest pain was the frequency of heartburn (odds ratio, 1.74; 95% confidence interval, 1.08-2.79; P = 0.02). None of the gastrointestinal (heartburn, dysphagia, acid regurgitation) or psychological (anxiety, depression, neuroticism) risk factors were significantly associated with consulting for non-cardiac chest pain.
   Conclusions: Non-cardiac chest pain is remarkably common in the general population and negatively impacts on the quality of life. Gastro-oesophageal reflux disease is a key risk factor for non-cardiac chest pain in the community. Health care seeking for non-cardiac chest pain remains unexplained.
C1 Univ Sydney, Nepean Hosp, Dept Med, Penrith, NSW 2751, Australia.
   Johnson & Johnson, New Brunswick, NJ USA.
C3 University of Sydney; Nepean Hospital; Johnson & Johnson; Johnson &
   Johnson USA
RP Univ Sydney, Nepean Hosp, Dept Med, Level 5,S Block,POB 63, Penrith, NSW 2751, Australia.
EM eslickg@med.usyd.edu.au
RI Eslick, Guy/HMT-5739-2023; Talley, Nicholas/D-5399-2013; Jones,
   Michael/A-9013-2013
OI Jones, Michael/0000-0003-0565-4938; Eslick, Guy/0000-0002-0098-1705
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NR 46
TC 185
Z9 195
U1 0
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0269-2813
EI 1365-2036
J9 ALIMENT PHARM THER
JI Aliment. Pharmacol. Ther.
PD MAY 1
PY 2003
VL 17
IS 9
BP 1115
EP 1124
DI 10.1046/j.1365-2036.2003.01557.x
PG 10
WC Gastroenterology & Hepatology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Gastroenterology & Hepatology; Pharmacology & Pharmacy
GA 674UB
UT WOS:000182653400004
PM 12752348
DA 2025-06-11
ER

PT J
AU Baeta, IGR
   Bittencourt, FV
   Gontijo, B
   Goulart, EMA
AF Ribeiro Baeta, Isabela Guimaraes
   Bittencourt, Flavia Vasques
   Gontijo, Bernardo
   Andrade Goulart, Eugenio Marcos
TI Comorbidities and cardiovascular risk factors in patients with psoriasis
SO ANAIS BRASILEIROS DE DERMATOLOGIA
LA English
DT Article
DE Comorbidity; Cardiovascular diseases; Psoriasis
ID METABOLIC SYNDROME; ALCOHOL INTAKE; DISEASE; PREVALENCE; ARTHRITIS;
   SMOKING; CARE
AB BACKGROUND: Psoriasis is a chronic inflammatory disease and its pathogenesis involves an interaction between genetic, environmental, and immunological factors. Recent studies have suggested that the chronic inflammatory nature of psoriasis may predispose to an association with other inflammatory diseases, especially cardiovascular diseases and metabolic disorders.
   OBJECTIVES: To describe the demographic, clinical, epidemiological, and laboratory characteristics of a sample of psoriasis patients; to assess the prevalence of cardiovascular comorbidities in this group of patients; and to identify the cardiovascular risk profile using the Framingham risk score.
   METHODS: We conducted a cross-sectional study involving the assessment of 190 patients. Participants underwent history and physical examination. They also completed a specific questionnaire about epidemiological data, past medical history, and comorbidities. The cardiovascular risk profile was calculated using the Framingham risk score.
   RESULTS: Patients' mean age was 51.5 +/- 14 years, and the predominant clinical presentation was plaque psoriasis (78.4%). We found an increased prevalence of systemic hypertension, type 2 diabetes, metabolic syndrome, and obesity. Increased waist circumference was also found in addition to a considerable prevalence of depression, smoking, and regular alcohol intake. Patients' cardiovascular risk was high according to the Framingham risk score, and 47.2% of patients had moderate or high risk of fatal and non-fatal coronary events in 10 years.
   CONCLUSIONS: Patients had high prevalence of cardiovascular comorbidities, and high cardiovascular risk according to the Framingham risk score. Further epidemiological studies are needed in Brazil for validation of our results.
C1 [Ribeiro Baeta, Isabela Guimaraes; Bittencourt, Flavia Vasques; Gontijo, Bernardo; Andrade Goulart, Eugenio Marcos] Univ Fed Minas Gerais, Hosp Clin, Outpatient Clin Dermatol, Belo Horizonte, MG, Brazil.
C3 Universidade Federal de Minas Gerais
RP Baeta, IGR (corresponding author), Alameda Alvaro Celso 55, BR-30150260 Belo Horizonte, MG, Brazil.
EM isabelagribeiro@hotmail.com
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NR 40
TC 40
Z9 43
U1 0
U2 10
PU SOC BRASILEIRA DERMATOLOGIA
PI RIO DE JANEIRO RJ
PA AV RIO BRANCO, 39-18 ANDAR, RIO DE JANEIRO RJ, 20090-003, BRAZIL
SN 0365-0596
EI 1806-4841
J9 AN BRAS DERMATOL
JI An. Brasil. Dermatol.
PD SEP-OCT
PY 2014
VL 89
IS 5
BP 735
EP 744
DI 10.1590/abd1806-4841.20142874
PG 10
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA AP0SE
UT WOS:000341773300005
PM 25184912
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Pano, O
   Martinez-Lapiscina, EH
   Sayón-Orea, C
   Martinez-Gonzalez, MA
   Martinez, JA
   Sanchez-Villegas, A
AF Pano, Octavio
   Martinez-Lapiscina, Elena H.
   Sayon-Orea, Carmen
   Martinez-Gonzalez, Miguel Angel
   Martinez, Jose Alfredo
   Sanchez-Villegas, Almudena
TI Healthy diet, depression and quality of life: A narrative review of
   biological mechanisms and primary prevention opportunities
SO WORLD JOURNAL OF PSYCHIATRY
LA English
DT Review
DE Depression; Nutrition; Mediterranean; Quality of life; Primary
   prevention; Epidemiology
ID POLYUNSATURATED FATTY-ACIDS; NECROSIS-FACTOR-ALPHA; C-REACTIVE PROTEIN;
   MEDITERRANEAN DIET; OLDER-ADULTS; SEGUIMIENTO-UNIVERSIDAD;
   ANTIDEPRESSANT RESPONSE; PERIPHERAL CYTOKINE; NEUROTROPHIC FACTOR;
   METABOLIC SYNDROME
AB Unipolar depressive disorder (UDD) affects more than 264 million people worldwide and was projected well before the severe acute respiratory syndrome coronavirus 2 pandemic to be the leading cause of disability-adjusted life years lost in 2030. It is imperative for leading economies to implement preventive strategies targeted towards UDD, given consistent policies are currently lacking. Recently established similarities between the aetiological hypotheses of depression and cardiometabolic diseases are shifting paradigms within this field. It is believed that dietary practices could potentially reduce the incidence of depression; similar to their effects on metabolism. Thus, the aim of this review was to compile current evidence on healthy dietary patterns as suitable contributors towards primary prevention strategies against UDD. Most of the well-known biological mechanisms behind depression have been positively associated with healthful diets and dietary patterns to varying degrees. Interestingly, a common factor of UDD is the production and overall effects of inflammatory cytokines, such as interleukin-6, tumor necrosis factor-alpha, and C-reactive protein. These compounds have been associated with depressive symptoms, disturbances in neuroendocrine function, leaky gut, monoamine activity and brain function, while also being key factors in the development of cardiometabolic diseases. The Mediterranean diet (MD) in particular, is well supported by first-level evidence regarding its preventive qualities against metabolic and cardiovascular diseases and thus considered a model for healthy eating by various organizations. In one of the few clinical trials investigating these associations, the PREDIMED trial, individuals with diabetes assigned to a MD supplemented with mixed tree nuts experienced a 41% relative risk reduction for developing depression. Lastly, there is a need to include health related quality of life as an indicator of physical and mental well-being, considering its putative associations with depression and suicide risk. Going forward, focusing on clinical trials, using precise nutritional assessments, and identifying nutritional biomarkers which may be related to depression are needed to fully support the implementation of dietary recommendations in the field of psychiatry.
C1 [Pano, Octavio; Martinez-Gonzalez, Miguel Angel] Univ Navarra, Prevent Med & Publ Hlth, Pamplona 31008, Spain.
   [Martinez-Lapiscina, Elena H.] Hosp Clin Barcelona, Inst Invest Biomed August Pi Sunyer, Ctr Neuroimmunol, Dept Neurol, Barcelona 08036, Spain.
   [Sayon-Orea, Carmen] Univ Navarra, Dept Prevent Med & Publ Hlth, Pamplona 31008, Spain.
   [Sayon-Orea, Carmen; Martinez, Jose Alfredo] Navarra Inst Hlth Res, IdiSNA, Pamplona 31008, Spain.
   [Sayon-Orea, Carmen] Navarra Inst Publ Hlth & Epidemiol, Dept Publ Hlth, Pamplona 31003, Spain.
   [Martinez-Gonzalez, Miguel Angel; Martinez, Jose Alfredo; Sanchez-Villegas, Almudena] Inst Hlth Carlos III, CIBER Pathophysiol Obes & Nutr, Madrid 28049, Spain.
   [Martinez-Gonzalez, Miguel Angel] Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA.
   [Martinez, Jose Alfredo] Univ Navarra, Dept Food Sci & Physiol, Pamplona 31008, Spain.
   [Martinez, Jose Alfredo] IMDEA Food Inst, Precis Nutr & Cardiometab Hlth Program, Madrid 28049, Spain.
   [Sanchez-Villegas, Almudena] Univ Las Palmas Gran Canaria, Dept Clin, Las Palmas Gran Canaria 35080, Spain.
C3 University of Navarra; University of Barcelona; Hospital Clinic de
   Barcelona; IDIBAPS; University of Navarra; University of Navarra; CIBER
   - Centro de Investigacion Biomedica en Red; CIBEROBN; Harvard
   University; Harvard T.H. Chan School of Public Health; University of
   Navarra; IMDEA Food Institute; Universidad de Las Palmas de Gran Canaria
RP Sanchez-Villegas, A (corresponding author), Univ Las Palmas Gran Canaria, Dept Clin Sci, POB 550, Las Palmas Gran Canaria 35080, Spain.
EM asanchez@dcc.ulpgc.es
RI Sanchez-Villegas, Almudena/T-6733-2019; Martínez-Lapiscina,
   Elena/L-1161-2014; Martinez-Gonzalez, Miguel/AAE-7669-2019; Pano
   Espinola, Octavio/LMO-0860-2024; Sayon-Orea, Carmen/A-9828-2017
OI Sayon-Orea, Carmen/0000-0002-4137-3263
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NR 136
TC 23
Z9 24
U1 0
U2 28
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 7041 Koll Center Parkway, Suite 160, PLEASANTON, CA, UNITED STATES
SN 2220-3206
J9 WORLD J PSYCHIATR
JI World J. Psychiatr.
PD NOV 19
PY 2021
VL 11
IS 11
BP 997
EP 1016
DI 10.5498/wjp.v11.i11.997
PG 20
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA XJ6MU
UT WOS:000726900300005
PM 34888169
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Manolis, TA
   Manolis, AA
   Manolis, AS
AF Manolis, Theodora A.
   Manolis, Antonis A.
   Manolis, Antonis S.
TI Cardiovascular Safety of Psychiatric Agents: A Cautionary Tale
SO ANGIOLOGY
LA English
DT Review
DE antipsychotics; schizophrenia; antidepressants; depression;
   cardiovascular disease; metabolic syndrome; postural hypotension;
   acquired long QTc syndrome; torsade de pointes; sudden cardiac death;
   acute coronary syndrome; myocardial infarction
ID SEROTONIN REUPTAKE INHIBITORS; ACUTE MYOCARDIAL-INFARCTION; INDUCED
   WEIGHT-GAIN; CORONARY-HEART-DISEASE; TORSADES-DE-POINTES; PROLONGS
   CARDIAC REPOLARIZATION; ATYPICAL ANTIPSYCHOTIC-DRUGS; NEW-ZEALAND
   COLLEGE; C-REACTIVE PROTEIN; DOUBLE-BLIND
AB Psychiatric agents are among the most commonly prescribed medications. Despite the advent of newer generation agents, patients receiving them still experience cardiovascular (CV) side effects. However, these agents may have heterogeneous properties, calling for an individualized approach based on efficacy and also on the particular side effect profile of each specific agent. Proarrhythmic effects arising from drug-induced long-QT syndrome and consequent potentially life-threatening polymorphic ventricular arrhythmias in the form of torsade de pointes, the metabolic syndrome contributing to atherosclerosis and acute coronary syndromes, and drug-induced orthostatic hypotension raise major concerns. Of course, it is also crucial that fear of potential CV adverse effects does not deprive psychiatric patients of appropriate drug therapy. Modification of CV risk factors in psychiatric patients together with optimal management of their CV diseases and appropriate selection of psychotropic agents with greater efficacy and least CV toxicity are of paramount importance in mitigating CV risks and enhancing safety. Identifying patients at high risk of CV complications and close monitoring of all patients receiving these agents are crucial steps to prevent and manage such complications. All these issues are herein reviewed, relevant guidelines are discussed, and schemas are depicted that illustrate the interrelated connections among the psychotropic agents and their CV effects.
C1 [Manolis, Theodora A.] Zakynthos Hosp, Zakynthos, Greece.
   [Manolis, Antonis A.] Univ Patras, Sch Med, Patras, Greece.
   [Manolis, Antonis S.] Athens Univ, Sch Med, Dept Cardiol 3, Athens, Greece.
C3 University of Patras; National & Kapodistrian University of Athens;
   Athens Medical School
RP Manolis, AS (corresponding author), Athens Univ, Sch Med, Dept Cardiol 3, Hippokratio Hosp, Vas Sofias 114, Athens 11527, Greece.
EM asm@otenet.gr
RI Manolis, Theodora A./GSI-9370-2022; Manolis, Antonis/F-5003-2014
OI Manolis, Theodora A./0000-0001-7611-0984; Manolis,
   Antonis/0000-0002-0336-4745
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   Wysokinski A, 2015, NORD J PSYCHIAT, V69, P346, DOI 10.3109/08039488.2014.984755
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NR 220
TC 19
Z9 20
U1 1
U2 18
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0003-3197
EI 1940-1574
J9 ANGIOLOGY
JI Angiology
PD FEB
PY 2019
VL 70
IS 2
BP 103
EP 129
DI 10.1177/0003319718780145
PG 27
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Cardiovascular System & Cardiology
GA HG4JU
UT WOS:000454942400002
PM 29874922
DA 2025-06-11
ER

PT J
AU Maksimovic, M
   Vlajinac, H
   Radak, D
   Marinkovic, J
   Maksimovic, J
   Jorga, J
AF Maksimovic, Milos
   Vlajinac, Hristina
   Radak, Djordje
   Marinkovic, Jelena
   Maksimovic, Jadranka
   Jorga, Jagoda
TI Sex Differences of Cardiovascular Risk Factors in Patients with
   Symptomatic Carotid Disease
SO SRPSKI ARHIV ZA CELOKUPNO LEKARSTVO
LA English
DT Article
DE carotid disease; atherosclerotic risk factors; gender
ID INTIMA-MEDIA THICKNESS; METABOLIC SYNDROME; GENDER-DIFFERENCES;
   ENDOTHELIAL DYSFUNCTION; ASSOCIATION; ATHEROSCLEROSIS; ENDARTERECTOMY;
   MENOPAUSE; ESTROGENS; EVENTS
AB Introduction Cardiovascular diseases, especially heart disease and stroke are the cause of more than a half of the total number of deaths in Serbia.
   Objectives The aim of the present study was to determine sex differences of atherosclerotic risk factors in patients with symptomatic carotid disease.
   Methods The cross-sectional study, involving 657 consecutive patients with verified carotid atherosclerotic disease, was performed in Belgrade, Serbia. Sex differences of anthropometric parameters and atherosclerotic risk factors were analyzed by means of the univariate logistic regression.
   Results In comparison with men, lower education and physical inactivity were significantly more frequent in women, and the frequency of metabolic syndrome (MetS), lower high-density cholesterol, abdominal obesity, body mass index >= 30.0 kg/m(2), hypercholesterolemia and depression were also significantly higher in women. Smoking and high serum uric acid level were significantly more frequent in men than in women. Women had significantly higher number of MetS components per person, but there were no significant sex differences in the number of other risk factors. Out of all observed risk factors, including MetS components, physical inactivity and hypertension were most frequent in both sexes followed by ever smoking and low education in men and low education and dyslipidemia in women.
   Conclusion There were significant sex differences in the distribution of some atherosclerotic risk factors, but not in their number per person. Only the number of MetS components was significantly higher in women.
C1 [Maksimovic, Milos; Jorga, Jagoda] Univ Belgrade, Sch Med, Inst Hyg & Med Ecol, Belgrade, Serbia.
   [Vlajinac, Hristina; Maksimovic, Jadranka] Univ Belgrade, Sch Med, Inst Epidemiol, Belgrade, Serbia.
   [Radak, Djordje] Dedinje Cardiovasc Inst, Dept Vasc Surg, Belgrade, Serbia.
   [Radak, Djordje] Univ Belgrade, Sch Med, Belgrade, Serbia.
   [Marinkovic, Jelena] Univ Belgrade, Sch Med, Inst Med Stat & Informat, Belgrade, Serbia.
C3 University of Belgrade; University of Belgrade; University of Belgrade;
   University of Belgrade
RP Maksimovic, M (corresponding author), Sch Med, Inst Hyg & Med Ecol, Dr Subotica 8, Belgrade 11000, Serbia.
EM milos.maksimovic@mfub.bg.ac.rs
RI Maksimović, Miloš/ABF-7728-2021; jorga, jagoda/I-1383-2012
OI Vlajinac, Hristina/0000-0002-8239-2989; Maksimovic,
   Jadranka/0000-0002-8215-7399; Maksimovic, Milos/0000-0002-6346-3171
FU Ministry of Education, Science and Technological Development, Serbia
   [III41002]
FX This work was supported by the Ministry of Education, Science and
   Technological Development, Serbia, through contract no. III41002
   (2011-2014).
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NR 34
TC 0
Z9 0
U1 0
U2 6
PU SRPSKO LEKARSKO DRUSTVO
PI BEOGRAD
PA UREDNISTVO CASOPISA SRPSKI ARHIV, UL DZORDZA VASINGTONA 19, BEOGRAD,
   11000, SERBIA
SN 0370-8179
J9 SRP ARK CELOK LEK
JI Srp. Ark. Celok. Lek.
PD NOV-DEC
PY 2013
VL 141
IS 11-12
BP 758
EP 763
DI 10.2298/SARH1312758M
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 294ZO
UT WOS:000330086600006
PM 24502093
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Ruxton, CHS
   Gardner, EJ
   McNnulty, HM
AF Ruxton, C. H. S.
   Gardner, E. J.
   McNnulty, H. M.
TI Is Sugar Consumption Detrimental to Health? A Review of the Evidence
   19952006
SO CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
LA English
DT Review
DE Sucrose; obesity; diet adequacy; dental caries
ID BREAST-CANCER RISK; DEFICIT HYPERACTIVITY DISORDER; RANDOMIZED
   CONTROLLED-TRIAL; DIURNAL METABOLIC PROFILES; HIGH-CARBOHYDRATE DIETS;
   LACTIC-ACID PRODUCTION; MILK EXTRINSIC SUGARS; BODY-WEIGHT CONTROL;
   LOW-FAT DIETS; DENTAL-CARIES
AB Many countries set quantitative targets for added sugars, justifying this by expressing concern about the likely impact of sugar on weight control, dental health, diet quality, or metabolic syndrome. This review considers whether current intakes of sugar are harmful to health, and analyses recent literature using a systematic approach to collate, rank, and evaluate published studies from 1995-2006. Results from high quality obesity studies did not suggest a positive association between body mass index and sugar intake. Some studies, specifically on sweetened beverages, highlighted a potential concern in relation to obesity risk, although these were limited by important methodological issues. Diet adequacy appeared to be achieved across sugar intakes of 6 to 20% energy, depending on subject age. Studies on metabolic syndrome reported no adverse effects of sugar in the long-term, even at intakes of 40-50% energy. The evidence for colorectal cancer suggested an association with sugar, but this appeared to have been confounded by energy intake and glycemic load. There was no credible evidence linking sugar with attention-deficit, dementia, or depression. Regarding dental caries, combinations of sugar amount/frequency, fluoride exposure, and food adhesiveness were more reliable predictors of caries risk than the amount of sugar alone. Overall, the available evidence did not support a single quantitative sugar guideline covering all health issues.
C1 [Ruxton, C. H. S.] Nutr Commun, Cupar KY15 4EA, England.
   [McNnulty, H. M.] Univ Ulster, Sch Biomed Sci, Coleraine BT52 1SA, Londonderry, North Ireland.
C3 Ulster University
RP Ruxton, CHS (corresponding author), Nutr Commun, 6 Front Lebanon, Cupar KY15 4EA, England.
EM carrie@nutrition-communications.com
RI Ruxton, Carrie/GON-7831-2022
OI McNulty, Helene/0000-0002-4366-6457
FU Sugar Bureau (UK)
FX This review was made possible by a grant from the Sugar Bureau (UK), a
   condition of which was that Sugar Bureau representatives or associates
   played no role in the selection or methodological assessment of papers,
   nor in the interpretation or writing up of the results. Ruxton and
   Gardner reviewed the literature, while Ruxton and McNulty wrote the
   paper.
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   2002, CANADIAN FOOD GUIDE
NR 175
TC 94
Z9 110
U1 0
U2 89
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1040-8398
EI 1549-7852
J9 CRIT REV FOOD SCI
JI Crit. Rev. Food Sci. Nutr.
PY 2010
VL 50
IS 1
BP 1
EP 19
AR PII 918157476
DI 10.1080/10408390802248569
PG 19
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA 538PN
UT WOS:000273196500001
PM 20047137
DA 2025-06-11
ER

PT J
AU Suzuki, H
   Matsubara, H
   Koba, S
   Murakami, M
   Takeyama, Y
   Katagiri, T
AF Suzuki, H
   Matsubara, H
   Koba, S
   Murakami, M
   Takeyama, Y
   Katagiri, T
TI Clinical characteristics and follow-up in patients with microvascular
   angina
SO CIRCULATION JOURNAL
LA English
DT Article
DE endocardial biopsy; microvascular angina; syndrome X
ID NORMAL CORONARY-ARTERIES; LEFT-VENTRICULAR FUNCTION; SYNDROME-X; CHEST
   PAIN; ARTERIOGRAMS; CARDIOMYOPATHY; PROGNOSIS; PECTORIS; DISEASE
AB Arteriosclerosis of the small arteries is one of the main causes of microvascular angina, and although some reports have shown favorable prognoses, there is progressive reduction in left ventricular function. The present study evaluated the prognosis of microvascular angina in 86 Japanese patients (51 women, 35 men; average age, 59 9 years) who had ischemic ST segment depression, normal coronary angiograms and small artery sclerosis confirmed by endomyocardial biopsies. The mean follow-up period was 7.2+/-3.4 years. Questionnaires regarding their symptoms, cardiac medication, and now events were sent to all patients. Eighty-five patients (98.9%) were still alive at the end of the follow-up period. Chest pain remained in 35.3%; the degree of pain was unchanged in 18.8%, and had lessened in 11.8%. None of the patients died of cardiac events or suffered from a myocardial infarction. At the end of the follow-up period, calcium antagonist was used in 63.5% of patients. Seventeen patients (20.0%) were free of antianginal medication. The prognosis of microvascular angina diagnosed by strict criteria was favorable.
C1 Showa Univ, Sch Med, Dept Internal Med 3, Tokyo 142, Japan.
   Showa Univ, Fujigaoka Hosp, Dept Internal Med, Div Cardiol, Yokohama, Kanagawa 227, Japan.
C3 Showa University; Showa University
RP 1-5-8 Hatanodai,Shinagawa Ku, Tokyo 1428666, Japan.
EM hrsuzuki@med.showa-u.ac.jp
RI Koba, Shinji/GZK-2961-2022
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NR 28
TC 18
Z9 19
U1 0
U2 0
PU JAPANESE CIRCULATION SOC
PI TOYKO
PA 6th Floor, Uchikanda Central Building, 1-18-13 Uchikanda, Chiyoda-ku,
   TOYKO, 101-0047, JAPAN
SN 1346-9843
EI 1347-4820
J9 CIRC J
JI Circ. J.
PD JUL
PY 2002
VL 66
IS 7
BP 691
EP 695
DI 10.1253/circj.66.691
PG 5
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 567XE
UT WOS:000176511100014
PM 12135140
OA Bronze
DA 2025-06-11
ER

PT J
AU Reser, JE
AF Reser, Jared E.
TI Schizophrenia and phenotypic plasticity: Schizophrenia may represent a
   predictive, adaptive response to severe environmental adversity that
   allows both bioenergetic thrift and a defensive behavioral strategy
SO MEDICAL HYPOTHESES
LA English
DT Review
ID HIPPOCAMPAL VOLUME REDUCTIONS; STRESSFUL LIFE EVENTS; BODY-MASS INDEX;
   EVOLUTIONARY NEUROPATHOLOGY; TAU HYPERPHOSPHORYLATION;
   MATERNAL-DEPRIVATION; METABOLIC SYNDROME; PRENATAL EXPOSURE;
   WORKING-MEMORY; LIMBIC SYSTEM
AB It is well recognized that investigation into the relationship between early life programming and subsequent neurological disorders may have powerful implications for understanding the human vulnerability to psychopathology. The present article will propose that schizophrenia may be adaptively programmed by early environmental adversity permitting physiological and behavioral characteristics that would have created a fitness advantage in the ancestral environment under conditions of nutritional scarcity and severe environmental stress. This proposition will be analyzed in terms of phenotypic plasticity theory which explains how and why specific environmental stressors can alter normal gene expression resulting in an alternative phenotype that is better suited for an adverse environment. The primary neurophysiological symptoms of schizophrenia can be induced in animals through exposure to prenatal and postnatal stressors, and that schizophrenia itself is known to be associated with exposure to stress during development, supports the view that the "disorder" may represent a predictive, adaptive response to adversity. In fact, maternal malnutrition, maternal stress, multiparity, short birth interval and stress provoking postnatal events are well recognized epidemiological risk factors for schizophrenia that may represent cues for the initiation of epigenetic programming.
   Behavioral and physiological characteristics of schizophrenia will be analyzed and interpreted as protective in the context of environmental hardship. For instance, the hypometabotic areas of the schizophrenic brain - the hippocampus and the frontal lobes - are the same areas that are known to become adaptively hypometabolic in response to starvation, stress and variations in ecological rigor in birds and mammals. Individuals with schizophrenia are also highly genetically inclined to develop the metabolic syndrome, which is widely thought to allow developmentally deprived mammals to conserve energy under poor circumstances. It is well known that schizophrenia features an up-regulated hypothalamic-pituitary-adrenal axis and an exaggerated stress response - both alterations thought to represent predictive, adaptive responses to stress in mammals - which may have increased attentiveness to the environment and created a defensive, vigilance-based behavioral strategy. The habituation deficits characteristic of schizophrenia - which can be induced in other mammals through stress - may represent a cognitive strategy that alerts the organism to salient, potentially informative stimuli and that permits it to be more impulsive and vigilant. Inability to calm instinctual drives, ignore arousing stimuli, and inhibit transient desires are all core characteristics of the disorder, which predict social and vocational disabilities in modern times, but may have amounted to a robust, selfish strategy in prehistoric times. (c) 2007 Elsevier Ltd. All rights reserved.
RP Reser, JE (corresponding author), 16380 Meadowridge Rd, Encino, CA 91436 USA.
EM jared@jaredreser.com
OI Reser, Jared/0000-0003-0580-3403
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NR 114
TC 16
Z9 18
U1 0
U2 8
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0306-9877
EI 1532-2777
J9 MED HYPOTHESES
JI Med. Hypotheses
PY 2007
VL 69
IS 2
BP 383
EP 394
DI 10.1016/j.mehy.2006.12.031
PG 12
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Research & Experimental Medicine
GA 185AN
UT WOS:000247683800028
PM 17321061
DA 2025-06-11
ER

PT J
AU Johnson, RJ
   Wilson, WL
   Bland, ST
   Lanaspa, MA
AF Johnson, Richard J.
   Wilson, William L.
   Bland, Sondra T.
   Lanaspa, Miguel A.
TI Fructose and uric acid as drivers of a hyperactive foraging response: A
   clue to behavioral disorders associated with impulsivity or mania?
SO EVOLUTION AND HUMAN BEHAVIOR
LA English
DT Article
DE High glycemic carbohydrates; Fructose; Foraging; HFCS; Sucrose;
   Impulsivity; Attention Deficit Hyperactivity Disorder; Starvation
ID ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; BIPOLAR DISORDER; METABOLIC
   SYNDROME; SUGAR CONSUMPTION; BRAIN DOPAMINE; RECEPTOR GENE;
   DOUBLE-BLIND; SOFT DRINKS; SWEETENED BEVERAGES; FLAVOR PREFERENCES
AB Several behavioral disorders, including attention deficit hyperactivity disorder (ADHD), bipolar disorder, and aggressive behaviors are linked with sugar intake and obesity. The reason(s) for this association has been unclear. Here we present a hypothesis supporting a role for fructose, a component of sugar and high fructose corn syrup (HFCS), and uric acid (a fructose metabolite), in increasing the risk for these behavioral disorders. Recent studies have shown that the reason fructose intake is strongly associated with development of metabolic syndrome is that fructose intake activates an evolutionary-based survival pathway that stimulates foraging behavior and the storage of energy as fat. While modest intake may aid animals that would like to store fat as a protective response from food shortage or starvation, we propose that high intake of sugar and HFCS causes a hyperactive foraging response that stimulates craving, impulsivity, risk taking and aggression that increases the risk for ADHD, bipolar disease and aggressive behavior. High glycemic carbohydrates and salty foods may also contribute as they can be converted to fructose in the body. Some studies suggest uric acid produced during fructose metabolism may mediate some of these effects. Chronic stimulation of the pathway could lead to desensitization of hedonic responses and induce depression. In conclusion, a hyperactive foraging response driven by high glycemic carbohydrates and sugars may contribute to affective disorders.
C1 [Johnson, Richard J.; Lanaspa, Miguel A.] Univ Colorado, Div Renal Dis, Anschutz Med Campus, Aurora, CO 80045 USA.
   [Wilson, William L.] New England Inpatient Specialists, N Andover, MA 01845 USA.
   [Bland, Sondra T.] Univ Colorado Denver, Dept Psychol, Denver, CO 80217 USA.
C3 University of Colorado System; University of Colorado Anschutz Medical
   Campus; Children's Hospital Colorado; University of Colorado System;
   University of Colorado Denver; University of Colorado Anschutz Medical
   Campus
RP Johnson, RJ (corresponding author), Univ Colorado, Div Renal Dis & Hypertens, Anschutz Med Campus,12700 East 19th Ave, Aurora, CO 80045 USA.
EM richard.johnson@ucdenver.edu
RI Lanaspa, Miguel/AAO-4971-2020
OI Bland, Sondra/0000-0002-5790-089X
FU NIH [DK 109408, UO1 AA027997]
FX Supported in part by NIH grant DK 109408 and NIH UO1 AA027997
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NR 178
TC 14
Z9 14
U1 0
U2 19
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1090-5138
EI 1879-0607
J9 EVOL HUM BEHAV
JI Evol. Hum. Behav.
PD MAY
PY 2021
VL 42
IS 3
BP 194
EP 203
DI 10.1016/j.evolhumbehav.2020.09.006
EA MAY 2021
PG 10
WC Psychology, Biological; Behavioral Sciences; Social Sciences, Biomedical
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Behavioral Sciences; Biomedical Social Sciences
GA SA9ON
UT WOS:000649632500003
PM 33994772
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Koller, A
   Balasko, M
   Bagi, Z
AF Koller, Akos
   Balasko, Marta
   Bagi, Zsolt
TI Endothelial regulation of coronary microcirculation in health and
   cardiometabolic diseases
SO INTERNAL AND EMERGENCY MEDICINE
LA English
DT Review
DE Coronary circulation; Obesity; Type 2 diabetes mellitus;
   Hyperhomocysteinemia; Wall shear stress; Endothelial function
ID METABOLIC SYNDROME; DIABETES-MELLITUS; ARTERIOLES; ACTIVATION; DILATION;
   OBESITY; OXIDASE; HEART; LEADS
AB Cardiometabolic disorders have been shown to impair coronary microvascular functions leading to diminished cardiac performance and increased mortality. In this review, we focus on the molecular pathomechanisms of impaired endothelium-dependent and flow-induced dysregulation of coronary vasomotor tone in cardiometabolic disorders such as obesity, diabetes mellitus or hyperhomocysteinemia based on animal experiments and human studies. We also briefly summarize the relationship among key signaling mechanisms that contribute to the development of coronary dysfunctions in these disorders, which may help develop new targets for efficient cardiometabolic prevention and treatments.
C1 [Koller, Akos; Balasko, Marta] Univ Pecs, Dept Pathophysiol & Gerontol, Sch Med, J Szentagothai Res Ctr, H-7624 Pecs, Hungary.
   [Koller, Akos] New York Med Coll, Dept Physiol, Valhalla, NY 10595 USA.
   [Bagi, Zsolt] Med Coll Georgia, Vasc Biol Ctr, GRU, Augusta, GA 30912 USA.
C3 University of Pecs; New York Medical College; University System of
   Georgia; Augusta University
RP Koller, A (corresponding author), Univ Pecs, Dept Pathophysiol & Gerontol, Sch Med, J Szentagothai Res Ctr, 12 Szigeti Str, H-7624 Pecs, Hungary.
EM akos.koller@aok.pte.hu
RI Ákos, Koller/Q-4672-2019
OI Bagi, Zsolt/0000-0001-8755-2980
FU American Heart Association; Founders Affiliate; NIH [PO-1 HL-43023];
   Hungarian National Science Research Fund (OTKA) [K71591, K67984,
   SROP-4.2.1/B-10/2/KONV-2010-0002, SROP-4.2.2.A-11/1/KONV-2012-0024]; 
   [0855910D]
FX The authors apologize, because many excellent reviews and studies could
   not be cited due to space limitation. Support: American Heart
   Association, Founders Affiliate, 0855910D, NIH PO-1 HL-43023, the
   Hungarian National Science Research Fund (OTKA) K71591 and K67984,
   SROP-4.2.1/B-10/2/KONV-2010-0002, SROP-4.2.2.A-11/1/KONV-2012-0024.
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NR 10
TC 24
Z9 25
U1 0
U2 14
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1828-0447
J9 INTERN EMERG MED
JI Intern. Emerg. Med.
PD APR
PY 2013
VL 8
SU 1
BP S51
EP S54
DI 10.1007/s11739-013-0910-5
PG 4
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 118FO
UT WOS:000317009400011
PM 23494539
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Freeman, AM
   Morris, PB
   Barnard, N
   Esselstyn, CB
   Ros, E
   Agatston, A
   Devries, S
   O'Keefe, J
   Miller, M
   Ornish, D
   Williams, K
   Kris-Etherton, P
AF Freeman, Andrew M.
   Morris, Pamela B.
   Barnard, Neal
   Esselstyn, Caldwell B.
   Ros, Emilio
   Agatston, Arthur
   Devries, Stephen
   O'Keefe, James
   Miller, Michael
   Ornish, Dean
   Williams, Kim
   Kris-Etherton, Penny
TI Trending Cardiovascular Nutrition Controversies
SO JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
LA English
DT Article
DE cardiovascular risk; fats green leafy vegetables; healthy dietary
   patterns; nutrition
ID GLUTEN-FREE DIET; CORONARY-HEART-DISEASE; METABOLIC SYNDROME STATUS;
   OLIVE OIL CONSUMPTION; LIFE-STYLE CHANGES; OXIDATIVE STRESS; NUT
   CONSUMPTION; CELIAC-DISEASE; BLOOD-PRESSURE; COCONUT OIL
AB The potential cardiovascular benefits of several trending foods and dietary patterns are still incompletely understood, and nutritional science continues to evolve. However, in the meantime, a number of controversial dietary patterns, foods, and nutrients have received significant media exposure and are mired by hype. This review addresses some of the more popular foods and dietary patterns that are promoted for cardiovascular health to provide clinicians with accurate information for patient discussions in the clinical setting. (C) 2017 by the American College of Cardiology Foundation.
C1 [Freeman, Andrew M.] Natl Jewish Hlth, Dept Med, Div Cardiol, 1400 Jackson St,J317, Denver, CO 80206 USA.
   [Morris, Pamela B.] Med Univ South Carolina, Charleston, SC USA.
   [Barnard, Neal] George Washington Univ, Sch Med, Washington, DC USA.
   [Barnard, Neal] Phys Comm Responsible Med, Washington, DC USA.
   [Esselstyn, Caldwell B.] Cleveland Clin, Wellness Inst, Cleveland, OH 44106 USA.
   [Ros, Emilio] Hosp Clin Barcelona, Lipid Clin, Endocrinol & Nutr Serv, Inst Invest Biomed August Pi & Sunyer, Barcelona, Spain.
   [Ros, Emilio] Inst Salud Carlos III, Ciber Fisiopatol Obesidad & Nutr, Madrid, Spain.
   [Agatston, Arthur] Florida Int Univ, Herbert Wertheim Coll Med, Miami, FL 33199 USA.
   [Agatston, Arthur] Baptist Hlth South Florida, Miami, FL USA.
   [Devries, Stephen] Gaples Inst Integrat Cardiol, Deerfield, IL USA.
   [Devries, Stephen] Northwestern Univ, Feinberg Sch Med, Chicago, IL 60611 USA.
   [O'Keefe, James] St Lukes Mid Amer Heart Inst, Kansas City, MO USA.
   [Miller, Michael] Univ Maryland, Sch Med, Baltimore, MD 21201 USA.
   [Ornish, Dean] Res Inst Prevent Med, Sausalito, CA USA.
   [Ornish, Dean] Univ Calif San Francisco, San Francisco, CA 94143 USA.
   [Williams, Kim] Rush Univ, Med Ctr, Chicago, IL 60612 USA.
   [Kris-Etherton, Penny] Penn State Univ, Dept Nutr Sci, University Pk, PA 16802 USA.
C3 National Jewish Health; Medical University of South Carolina; George
   Washington University; Cleveland Clinic Foundation; University of
   Barcelona; Hospital Clinic de Barcelona; IDIBAPS; CIBER - Centro de
   Investigacion Biomedica en Red; CIBEROBN; Instituto de Salud Carlos III;
   State University System of Florida; Florida International University;
   Northwestern University; Feinberg School of Medicine; Saint Luke's Mid
   America Heart Institute; University System of Maryland; University of
   Maryland Baltimore; University of California System; University of
   California San Francisco; Rush University; Pennsylvania Commonwealth
   System of Higher Education (PCSHE); Pennsylvania State University;
   Pennsylvania State University - University Park; Penn State Behrend
RP Freeman, AM (corresponding author), Natl Jewish Hlth, Dept Med, Div Cardiol, 1400 Jackson St,J317, Denver, CO 80206 USA.
EM andrew@docandrew.com
RI Miller, Michael/AGX-6773-2022
OI MILLER, MICHAEL/0000-0002-1679-2095; Ros, Emilio/0000-0002-2573-1294;
   Kris-Etherton, Penny/0000-0001-6012-4900
FU California Walnut Commission; Canola Oil Council; McCormick Spice
   Institute; National Cattlemen's Beef Association
FX Dr. Morris has served on advisory boards for Amgen, AstraZeneca, and
   Sanofi Regeneron. Dr. Ros has received grants for research through his
   institution from the California Walnut Commission and is a nonpaid
   member of its Scientific Advisory Committee. Dr. Miller is a Scientific
   Advisor for Pressed Juicery. Dr. Ornish consults with Healthways and
   TerraVia, and receives royalties as an author and honoraria as a
   speaker. Dr. O'Keefe has a financial interest in Cardiotabs, a
   nutritional supplement company; and has done promotional speaking for
   Boehringer Ingelheim, Amgen, and Sanofi Regeneron. Dr. Kris-Etherton
   serves on the California Walnut Commission Scientific Advisory
   Committee, Avocado Nutrition Sciences Advisors, Seafood Nutrition
   Partnership Scientific and Nutrition Advisory Council, McDonald's Global
   Advisory Council, and the TerraVia Scientific Advisory Board, and has
   research funding from the California Walnut Commission, Canola Oil
   Council, McCormick Spice Institute, and National Cattlemen's Beef
   Association.
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NR 145
TC 114
Z9 125
U1 1
U2 54
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0735-1097
EI 1558-3597
J9 J AM COLL CARDIOL
JI J. Am. Coll. Cardiol.
PD MAR 7
PY 2017
VL 69
IS 9
BP 1172
EP 1187
DI 10.1016/j.jacc.2016.10.086
PG 16
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA EN9ZY
UT WOS:000396359300011
PM 28254181
DA 2025-06-11
ER

PT J
AU Monte, S
   Macchia, A
   Romero, M
   D'Ettorre, A
   Giuliani, R
   Tognoni, G
AF Monte, Simona
   Macchia, Alejandro
   Romero, Marilena
   D'Ettorre, Antonio
   Giuliani, Rachele
   Tognoni, Gianni
TI Antidepressants and cardiovascular outcomes in patients without known
   cardiovascular risk
SO EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
LA English
DT Article
DE Cardiovascular risk; Depression; Epidemiology
ID CORONARY-HEART-DISEASE; NUTRITION EXAMINATION SURVEY;
   MYOCARDIAL-INFARCTION; DEPRESSIVE SYMPTOMS; BLOOD-PRESSURE;
   YOUNG-ADULTS; FOLLOW-UP; ATRIAL-FIBRILLATION; METABOLIC SYNDROME;
   ELDERLY-PATIENTS
AB To identify a cohort of subjects without treatment for any cardiovascular risk and analyze the potential causative role of treatment for depression on the development of major cardiovascular outcomes during 2 years of follow-up.
   We carried out a record-linkage analysis of hospital discharge records, prescription databases and vital statistics for all consecutive patients aged 30 years or older in one Italian region during a 4-year period. Depression was defined in terms of exposure to at least three prescriptions of antidepressant drugs within 1 year. Patients had no history of treatment with cardiovascular or antidiabetic agents and had not been hospitalized with a diagnosis of any cardiovascular condition in the preceding year. Follow-up was extended up to 2 years or to time to occurrence of major outcomes defined as either all-cause mortality, hospitalization for any cardiovascular cause or chronic exposure to cardiovascular drugs (antihypertensive, statins, antidiabetics). The results are expressed hazard ratios (HRs) and 95% confidence intervals (CIs) within age categories (30-49, 50-59, a parts per thousand yen60 years).
   A total of 105,573 persons without treated cardiovascular risk at baseline were identified, among whom 1,129 (1.1%) had been chronically exposed to antidepressant treatment. Treated depression determined an increased risk of all cause-mortality (HR 1.88, 95% CI 1.33-2.66, p < 0.001) and of subsequent treatment with antidiabetic agents (HR 0.89, 95% CI 1.34-2.66, p < 0.001), statins (HR 1.87, 95% CI 1.53-2.29, p < 0.001) and antihypertensive drugs (HR 1.25, 95% CI 1.07-1.47, p = 0.006).
   Among the general population without treated cardiovascular risk, pharmacologic treatment for depression was associated with an increase in all-cause mortality and major cardiovascular outcomes.
C1 [Monte, Simona; Macchia, Alejandro; Romero, Marilena; D'Ettorre, Antonio; Giuliani, Rachele; Tognoni, Gianni] Consorzio Mario Negri Sud, Lab Pharmacoepidemiol, Dept Clin Pharmacol & Epidemiol, Chieti, Italy.
   [Macchia, Alejandro] GESICA Fdn, Buenos Aires, DF, Argentina.
C3 Consorzio Mario Negri Sud
RP Monte, S (corresponding author), Consorzio Mario Negri Sud, Lab Pharmacoepidemiol, Dept Clin Pharmacol & Epidemiol, Via Nazl Lanciano,1, Chieti, Italy.
EM monte@negrisud.it
RI Macchia, Alejandro/AAV-9665-2020; D'Ettorre, Antonio/ABG-2375-2020
OI Macchia, Alejandro/0000-0002-5424-5009; D'Ettorre,
   Antonio/0000-0002-5880-4234
FU Rischio Assoluto Cardiovascolare-Epidemiologia (RIACE) Project; Agenzia
   Italiana del Farmaco (AIFA) [FARM5T8T47]
FX This work has been partially funded by the Rischio Assoluto
   Cardiovascolare-Epidemiologia (RIACE) Project, funded by the Agenzia
   Italiana del Farmaco (AIFA), Project FARM5T8T47.
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NR 41
TC 16
Z9 17
U1 0
U2 4
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0031-6970
EI 1432-1041
J9 EUR J CLIN PHARMACOL
JI Eur. J. Clin. Pharmacol.
PD NOV
PY 2009
VL 65
IS 11
BP 1131
EP 1138
DI 10.1007/s00228-009-0692-x
PG 8
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 508ZR
UT WOS:000270980200009
PM 19597805
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Brody, GH
   Lei, MK
   Chen, E
   Miller, GE
AF Brody, Gene H.
   Lei, Man-Kit
   Chen, Edith
   Miller, Gregory E.
TI Neighborhood Poverty and Allostatic Load in African American Youth
SO PEDIATRICS
LA English
DT Article
DE African Americans; allostasis; physiology; human development; poverty
ID CUMULATIVE RISK; PUBERTAL CHANGES; STRESS; CHILDHOOD; ADULTS;
   STRATEGIES; MACARTHUR; PATTERN
AB OBJECTIVE: This study was designed to determine whether living in a neighborhood in which poverty levels increase across adolescence is associated with heightened levels of allostatic load (AL), a biological composite reflecting cardiometabolic risk. The researchers also sought to determine whether receipt of emotional support could ameliorate the effects of increases in neighborhood poverty on AL.
   METHODS: Neighborhood concentrations of poverty were obtained from the Census Bureau for 420 African American youth living in rural Georgia when they were 11 and 19 years of age. AL was measured at age 19 by using established protocols for children and adolescents. When youth were 18, caregivers reported parental emotional support and youth assessed receipt of peer and mentor emotional support. Covariates included family poverty status at ages 11 and 19, family financial stress, parental employment status, youth stress, and youths' unhealthful behaviors.
   RESULTS: Youth who lived in neighborhoods in which poverty levels increased from ages 11 to 19 evinced the highest levels of AL even after accounting for the individual-level covariates. The association of increasing neighborhood poverty across adolescence with AL was not significant for youth who received high emotional support.
   CONCLUSIONS: This study is the first to show an association between AL and residence in a neighborhood that increases in poverty. It also highlights the benefits of supportive relationships in ameliorating this association.
C1 [Brody, Gene H.; Lei, Man-Kit] Univ Georgia, Ctr Family Res, Athens, GA 30602 USA.
   [Chen, Edith; Miller, Gregory E.] Northwestern Univ, Dept Psychol, Evanston, IL USA.
   [Chen, Edith; Miller, Gregory E.] Northwestern Univ, Inst Policy Res, Evanston, IL USA.
C3 University System of Georgia; University of Georgia; Northwestern
   University; Northwestern University
RP Brody, GH (corresponding author), Univ Georgia, Ctr Family Res, 1095 Coll Stn Rd, Athens, GA 30602 USA.
EM gbrody@uga.edu
RI Lei, Man/AAM-9616-2020
OI Lei, Man-Kit/0000-0002-7757-6548; Miller, Gregory/0000-0002-7217-1082
FU NIH [R01 HD030588, P30 DA027827]; National Institutes of Health (NIH)
FX Supported by NIH grants R01 HD030588 and P30 DA027827. Funded by the
   National Institutes of Health (NIH).
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NR 43
TC 74
Z9 91
U1 1
U2 30
PU AMER ACAD PEDIATRICS
PI ELK GROVE VILLAGE
PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA
SN 0031-4005
EI 1098-4275
J9 PEDIATRICS
JI Pediatrics
PD NOV
PY 2014
VL 134
IS 5
BP E1362
EP E1368
DI 10.1542/peds.2014-1395
PG 7
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Pediatrics
GA AS6PU
UT WOS:000344385900012
PM 25311604
OA Green Published
DA 2025-06-11
ER

PT J
AU Lee, DY
   Kim, C
   Shin, Y
   Park, RW
AF Lee, Dong Yun
   Kim, Chungsoo
   Shin, Yunmi
   Park, Rae Woong
TI Combined Methylphenidate and Selective Serotonin Reuptake Inhibitors in
   Adults With Attention-Deficit/Hyperactivity Disorder
SO JAMA NETWORK OPEN
LA English
DT Article
ID QUALITY-OF-LIFE; HYPERACTIVITY DISORDER; DEPRESSIVE/ANXIETY SYMPTOMS;
   METABOLIC SYNDROME; DEFICIT; ADHD; GENDER; ANTIDEPRESSANTS; ADOLESCENTS;
   PREVALENCE
AB Importance Depression is a common comorbidity of adult attention-deficit/hyperactivity disorder (ADHD), and the combination of methylphenidate and selective serotonin reuptake inhibitors (SSRIs) is a frequently prescribed treatment. However, there is limited clinical evidence on the safety of this medication combination in adults with ADHD. Objective To evaluate the safety of administering a combination of SSRI and methylphenidate in adults with ADHD and comorbid depression. Design, Setting, and Participants This cohort study obtained data from a nationwide claims database in South Korea from January 2016 to February 2021. Participants were adults aged 18 years or older with a diagnosis of ADHD and depressive disorder who were prescribed methylphenidate. Comparisons of 4 groups who received prescriptions were conducted: (1) SSRI plus methylphenidate (hereafter, SSRI) group vs methylphenidate-only group and (2) methylphenidate plus fluoxetine (hereafter, fluoxetine) group vs methylphenidate plus escitalopram (hereafter, escitalopram) group (compared to find a preferable treatment option). Data analysis was conducted between July and December 2023. Exposures New users of the methylphenidate and SSRI combination among adults with both ADHD and depressive disorder. Main Outcomes and Measures A total of 17 primary and secondary outcomes, including neuropsychiatric and other events, were assessed, with respiratory tract infection used as a control outcome. Groups were matched at a 1:1 ratio using a propensity score to balance confounders. A Cox proportional hazards regression model was used to calculate hazard ratio (HRs) and 95% CIs. Subgroup analysis by sex and sensitivity analyses in varying epidemiologic settings were conducted. Results The study included 17 234 adults with ADHD (mean [SD] age at study entry, 29.4 [10.8] years; 9079 females [52.7%]). There was no difference in the risk of outcomes between the methylphenidate-only and SSRI groups, except for a lower risk of headache in the SSRI group (HR, 0.50; 95% CI, 0.24-0.99). In sensitivity analyses of fluoxetine vs escitalopram, the risk of hypertension (HR: 1:n matching, 0.26; 95% CI, 0.08-0.67) and hyperlipidemia (HR: 1:n matching, 0.23; 95% CI, 0.04-0.81) was lower in the fluoxetine group than in the escitalopram group. Conclusions and Relevance Results of this study revealed no significant increase in adverse event risk associated with use of SSRI plus methylphenidate vs methylphenidate alone in adults with ADHD and comorbid depression. Instead, the combination was associated with a lower risk of headache.
C1 [Lee, Dong Yun; Park, Rae Woong] Ajou Univ, Sch Med, Dept Biomed Informat, 206 Worldcup Ro, Suwon 16499, Gyeonggi, South Korea.
   [Lee, Dong Yun] Ajou Univ, Grad Sch, Dept Med Sci, Suwon, South Korea.
   [Kim, Chungsoo] Yale Univ, Sch Med, Dept Internal Med, Sect Cardiovasc Med, New Haven, CT USA.
   [Shin, Yunmi] Ajou Univ, Sch Med, Dept Psychiat, 206 Worldcup Ro, Suwon 16499, Gyeonggi, South Korea.
   [Park, Rae Woong] Ajou Univ, Grad Sch Med, Dept Biomed Sci, Suwon, South Korea.
C3 Ajou University; Ajou University; Yale University; Ajou University; Ajou
   University
RP Park, RW (corresponding author), Ajou Univ, Sch Med, Dept Biomed Informat, 206 Worldcup Ro, Suwon 16499, Gyeonggi, South Korea.; Shin, Y (corresponding author), Ajou Univ, Sch Med, Dept Psychiat, 206 Worldcup Ro, Suwon 16499, Gyeonggi, South Korea.
EM ymshin@ajou.ac.kr; veritas@ajou.ac.kr
RI Kim, Chungsoo/HSB-5238-2023
OI Kim, Chungsoo/0000-0003-1802-1777
FU Government-wide research and development (R&D) fund project for
   infectious disease research in South Korea [HG22C0024]; Korea Health
   Technology R&D Project through the Korea Health Industry Development
   Institute - Ministry of Health and Welfare in South Korea [HR16C0001];
   Health Insurance Review and Assessment Service (HIRA); The
   government-wide research and development (R&D) fund project for
   infectious disease research in South Korea; Korea Health Technology R&D
   Project through the Korea Health Industry Development Institute by the
   Ministry of Health and Welfare in South Korea; Health Insurance Review
   and Assessment Service (HIRA)
FX This research was funded by grant HG22C0024 (Dr Park) from a
   government-wide research and development (R&D) fund project for
   infectious disease research in South Korea and grant HR16C0001 (DrPark)
   from the Korea Health Technology R&D Project through the Korea Health
   Industry Development Institute, which is funded by the Ministry of
   Health and Welfare in South Korea, and was supported by the Health
   Insurance Review and Assessment Service (HIRA).
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NR 53
TC 0
Z9 0
U1 2
U2 3
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 2574-3805
J9 JAMA NETW OPEN
JI JAMA Netw. Open
PD OCT 9
PY 2024
VL 7
IS 10
AR e2438398
DI 10.1001/jamanetworkopen.2024.38398
PG 13
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA J4V2H
UT WOS:001337051100010
PM 39382893
OA gold
DA 2025-06-11
ER

PT J
AU Dagla, I
   Benaki, D
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   Brown, L
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AF Dagla, Ioanna
   Benaki, Dimitra
   Baira, Eirini
   Lemonakis, Nikolaos
   Poudyal, Hemant
   Brown, Lindsay
   Tsarbopoulos, Anthony
   Skaltsounis, Alexios-Leandros
   Mikros, Emmanouel
   Gikas, Evagelos
TI Alteration in the liver metabolome of rats with metabolic syndrome after
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   Resonance - based metabolomics study
SO TALANTA
LA English
DT Article
DE Metabolomics; Metabolic syndrome; MS; NMR; Hydroxytyrosol
ID INSULIN-RESISTANCE; LIPIDOMIC ANALYSIS; OXIDATIVE STRESS; DIET; OBESITY;
   NMR; IDENTIFICATION; COMPONENTS; DISCOVERY
AB Metabolic syndrome (MetS) represents a group of abnormalities that enhances the risk for cardiovascular disease, diabetes and stroke. The Mediterranean diet seems to be an important dietary pattern, which reduces the incidence of MetS. Hydroxytyrosol (HT)-a simple phenol found in olive oil-has received increased attention for its antioxidant activity. Recently, the European Foods Safety Authority (EFSA) claimed that dietary consumption of HT exhibits a protective role against cardiovascular disease. In this study, an experimental protocol has been setup, including isolated HT administration in a diet induced model of MetS in young Wistar rats, in order to find out whether HT has a protective effect against MetS. Rats were randomly divided into two groups nurtured by high-carbohydrate high-fat (H) (MetS inducing diet) and high-carbohydrate high-fat + HT (HHT). HT (20 mg/ kg/d oral gavage, water vehicle) was administered for 8 weeks on the basal diet. Previous pharmacological evaluation of HT showed that hepatic steatosis was reduced and the inflammatory cells into the liver were infiltrated. These indicate that HT shows bioactivity against metabolic syndrome. Therefore, the metabolomics evaluation of liver extracts would indicate the putative biochemical mechanisms of HT activity. Thus, the extracts of liver tissues were analyzed using Ultra Performance Liquid Chromatography High Resolution Mass Spectrometry (UPLC-HRMS, Orbitrap Discovery) and. Nuclear Magnetic Resonance (NMR) spectroscopy (Broker Avance III 600 MHz). Multivariate analysis was performed in order to gain insight on the metabolic effects of HT administration on the liver metabolome. Normalization employing multiple internal standards and Quality Control based Robust LOESS (Locally Estimated Scatterplot Smoothing) Signal Correction algorithm (QC-RLSC) was added in the processing pipeline to enhance the reliability of metabolomic analysis by reducing unwanted information. Experimentally, HHT rats were clearly distinguished from H in PLS-DA, showing differences in the liver metabolome between the groups and specific biomarkers were determined supporting the pharmacological findings. More specifically, HT has shown to be effective towards the mobilization of lipids as various lipid classes being differentially regulated between the H and HHT groups. Interestingly branched fatty acid esters of hydroxy oleic acids (OAHSA) lipids have been shown to be up regulated to the HHT group, denoting the alleviation of the MetS to the animals administered with HT.
C1 [Dagla, Ioanna; Benaki, Dimitra; Baira, Eirini; Mikros, Emmanouel; Gikas, Evagelos] Univ Athens, Sch Hlth Sci, Div Pharmaceut Chem, Lab Pharmaceut Anal,Fac Pharm, Athens 15771, Greece.
   [Lemonakis, Nikolaos; Skaltsounis, Alexios-Leandros] Univ Athens, Sch Hlth Sci, Div Pharmacognosy & Nat Prod Chem, Fac Pharm, Athens 15771, Greece.
   [Poudyal, Hemant] Kyoto Univ, Dept Diabet Endocrinol & Nutr, Hakubi Ctr Adv Res, Kyoto, Japan.
   [Brown, Lindsay] Univ Southern Queensland, Sch Hlth & Wellbeing, Toowoomba, Qld 4350, Australia.
   [Tsarbopoulos, Anthony] Univ Athens, Dept Descript Funct Studies, Lab Pharmacol, Fac Med, Athens, Greece.
C3 National & Kapodistrian University of Athens; National & Kapodistrian
   University of Athens; Kyoto University; University of Southern
   Queensland; National & Kapodistrian University of Athens
RP Mikros, E; Gikas, E (corresponding author), Univ Athens, Sch Hlth Sci, Div Pharmaceut Chem, Lab Pharmaceut Anal,Fac Pharm, Athens 15771, Greece.
EM mikros@pharm.uoa.gr; vgikas@pharm.uoa.gr
RI skaltsounis, alexios/AAE-9617-2019; Gikas, Evagelos/H-6226-2019; Mikros,
   Emmanuel/E-4223-2017; Poudyal, Hemant/HOH-9324-2023
OI BAIRA, EIRINI/0000-0003-4058-4031; Mikros, Emmanuel/0000-0002-5984-5169;
   BENAKI, DIMITRA/0000-0003-3072-204X
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NR 49
TC 18
Z9 20
U1 1
U2 67
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0039-9140
EI 1873-3573
J9 TALANTA
JI Talanta
PD FEB 1
PY 2018
VL 178
BP 246
EP 257
DI 10.1016/j.talanta.2017.09.029
PG 12
WC Chemistry, Analytical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry
GA FO2NH
UT WOS:000416615500034
PM 29136819
DA 2025-06-11
ER

PT J
AU Campaniello, D
   Bevilacqua, A
   Speranza, B
   Racioppo, A
   Sinigaglia, M
   Corbo, MR
AF Campaniello, Daniela
   Bevilacqua, Antonio
   Speranza, Barbara
   Racioppo, Angela
   Sinigaglia, Milena
   Corbo, Maria Rosaria
TI A narrative review on the use of probiotics in several diseases.
   Evidence and perspectives
SO FRONTIERS IN NUTRITION
LA English
DT Review
DE probiotics; disease; clinical trials; effects; genera
ID IRRITABLE-BOWEL-SYNDROME; COLORECTAL-CANCER RISK; GUT MICROBIOTA;
   DOUBLE-BLIND; AKKERMANSIA-MUCINIPHILA; FERMENTED MILK; GERM-FREE;
   PLACEBO; METAANALYSIS; DEPRESSION
AB Gut microbiota is a complex ecosystem, strictly linked to health and disease, as a balanced composition (referred as eubiosis) is necessary for several physiological functions, while an unbalanced composition (dysbiosis) is often associated to pathological conditions and/or diseases. An altered microbiota could be positively affected and partially restored through probiotic supplementation, among others. This review addresses the effects of probiotics in several conditions, used as case-studies (colorectal cancer, neuro-psychiatric diseases, intestinal diseases, obesity, diabetes, metabolic syndrome, immune system, and musculoskeletal system disorders) by pointing out the clinical outcomes, the mode of action, mainly related to the production of short chain fatty acids (SCFA), the impact of probiotic dose and mode of supplementation, as well as trying to highlight a hit of the most used genera.
C1 [Campaniello, Daniela; Bevilacqua, Antonio; Speranza, Barbara; Racioppo, Angela; Sinigaglia, Milena; Corbo, Maria Rosaria] Univ Foggia, Dept Agr Food Nat Resources & Engn, Foggia, Italy.
C3 University of Foggia
RP Corbo, MR (corresponding author), Univ Foggia, Dept Agr Food Nat Resources & Engn, Foggia, Italy.
EM mariarosaria.corbo@unifg.it
RI Racioppo, Angela/ADL-2285-2022
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NR 142
TC 10
Z9 11
U1 0
U2 10
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD JUL 10
PY 2023
VL 10
AR 1209238
DI 10.3389/fnut.2023.1209238
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA N2IL9
UT WOS:001035310400001
PM 37497058
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Sharma, K
   Poudyal, S
   Subba, HK
   Khatiwada, S
AF Sharma, Kalpana
   Poudyal, Sunita
   Subba, Hem K.
   Khatiwada, Saurav
TI Metabolic syndrome and life style factors among diabetes patients
   attending in a teaching hospital, Chitwan
SO PLOS ONE
LA English
DT Article
ID PREVALENCE; COMPONENTS; DISEASE; SLEEP
AB BackgroundMetabolic syndrome (MetS) is associated with an increased incidence of chronic complications and mortality of diabetes patients. Prevention and treatment of MetS is important means of lowering the risk of cardiovascular diseases and mortality. ObjectiveThis study aimed to find out metabolic syndrome and life style factors among diabetes patients. MethodsA cross-sectional survey was carried out among 296 patients with type 2 diabetes mellitus attending Chitwan Medical College Teaching Hospital. Consecutive sampling technique was used to select sample. Data were collected from 15(th) December 2021 to 15(th) March, 2022 using Interview Schedule, bio-physiological measurement and record review. Obtained data were analysed in SPSS version 20 for window using descriptive and inferential statistics. Chi-square test was applied to measure the association between the variables. Logistic regression analysis was performed to identify the factors associated with metabolic syndrome. ResultFindings revealed that the prevalence of MetS was 66.2% and 58.4% in patients according to International Diabetes Federation (IDF) and National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) criteria respectively. The most common MetS parameters were raised fasting plasma glucose (94.6%) and abnormal waist circumference (78.4% in IDF criteria) while the least prevalent parameter was reduced HDL level (43.2%). Majorities of the patients were non-vegetarian (85.5%), had poor dietary compliance (poor-46.3%, very poor-32.1%), overweight/obese (65.5%), and suffered from moderate stress (90.1%). Bivariate analysis showed that MetS as per NCEP ATP criteria was significantly associated with gender (p = 0.006), occupation (p = 0.007), presence of other co-morbid condition (<0.001) and sleep problem (p = <0.001). However, MetS as per IDF criteria was significantly associated with age (p = <0.028), duration of diabetes (p = <0.001), follow-up visit (p = <0.030), blood sugar monitoring (p = <0.009) and physical activity of diabetes patients (p = <0.001). Further logistic regression analysis revealed that sleep problem (AOR = 21.812;95%CI = 8.512,55.894) and presence of other comorbidities (AOR = 4.024;95%CI = 2.220,7.295) were the significant factors of metabolic syndrome. Conclusion and recommendationMetabolic syndrome is high in patients with type 2 diabetes mellitus. Therefore, treating physicians and other health workers need to monitor MetS parameters regularly to reduce the risk of cardiovascular diseases, stroke and premature death.
C1 [Sharma, Kalpana; Poudyal, Sunita; Subba, Hem K.] Chitwan Med Coll, Sch Nursing, Bharatpur, Nepal.
   [Khatiwada, Saurav] Chitwan Med Coll, Dept Endocrine Med, Bharatpur, Nepal.
RP Sharma, K (corresponding author), Chitwan Med Coll, Sch Nursing, Bharatpur, Nepal.
EM sharma.kalpana@cmc.edu.np
RI SHARMA, KALPANA/HCH-4334-2022
OI Sharma, Kalpana/0000-0001-8761-8505
FU Nepal Health Research Council
FX This study was funded by Nepal Health Research Council as provincial
   research grant. The funders had no role in study design, data collection
   and analysis, decision to publish, or preparation of manuscript.
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NR 35
TC 3
Z9 3
U1 0
U2 1
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAY 25
PY 2023
VL 18
IS 5
DI 10.1371/journal.pone.0286139
PG 17
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA H4ZZ2
UT WOS:000996075100061
PM 37228052
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Xu, ZY
   Zheng, H
   Pan, ZJ
   Hu, SY
   Wang, YX
   Su, WJ
AF Xu, Zhang-Yang
   Zheng, Hong
   Pan, Zi-Jun
   Hu, Shou-Yi
   Wang, Yun-Xia
   Su, Wen-Jun
TI Association between triglyceride-glucose (TyG) index and risk of
   depression in middle-aged and elderly Chinese adults: Evidence from a
   large national cohort study
SO BIOMOLECULES AND BIOMEDICINE
LA English
DT Article; Early Access
ID INSULIN-RESISTANCE; METABOLIC SYNDROME; CARDIOVASCULAR-DISEASE;
   MENTAL-ILLNESS; PREVALENCE; WOMEN; METAANALYSIS; INDIVIDUALS; DISORDERS;
   PEOPLE
AB The BiomolBiomed publishes an "Advanced Online" manuscript format as a free service to authors in order to expedite the dissemination of scientific findings to the research community as soon as possible after acceptance following peer review and corresponding modification (where appropriate). An "Advanced Online" manuscript is published online prior to copyediting, formatting for publication and author proofreading, but is nonetheless fully citable through its Digital Object Identifier (doi (R)). Nevertheless, this "Advanced Online" version is NOT the final version of the manuscript. When the final version of this paper is published within a definitive issue of the journal with copyediting, full pagination, etc., the new final version will be accessible through the same doi and this "Advanced Online" version of the paper will disappear.
C1 [Xu, Zhang-Yang; Zheng, Hong; Su, Wen-Jun] Second Mil Med Univ, Fac Psychol, Dept Stress Med, Shanghai, Peoples R China.
   [Xu, Zhang-Yang; Wang, Yun-Xia] Second Mil Med Univ, Fac Psychol, Dept Naut Psychol, Shanghai, Peoples R China.
   [Pan, Zi-Jun] Naval Med Univ, Changzheng Hosp, Dept Med Psychol, Shanghai, Peoples R China.
   [Hu, Shou-Yi] Chinese Peoples Liberat Army Gen Hosp, Med Sch Chinese PLA, Dept Endocrinol, Beijing, Peoples R China.
C3 Naval Medical University; Naval Medical University; Naval Medical
   University; Chinese People's Liberation Army General Hospital
RP Su, WJ (corresponding author), Second Mil Med Univ, Fac Psychol, Dept Stress Med, Shanghai, Peoples R China.; Wang, YX (corresponding author), Second Mil Med Univ, Fac Psychol, Dept Naut Psychol, Shanghai, Peoples R China.
EM cloudywang66@163.com; suwenjun1992@163.com
RI Pan, Zijun/LFS-1175-2024; Su, Wen-Jun/KPA-3786-2024
OI Xu, ZhangYang/0000-0003-3352-5324; Su, Wen-Jun/0000-0002-2707-3600
FU National Natural Science Foundation of China [82101607]; Shanghai
   Sailing Program [20YF1458300]; Opening Project of Hubei Key Laboratory
   of Cognitive and Affective Disorders [HBCAD2024-04]; Research Project
   for Basic Medicine [MS2024005]
FX This work was supported by the National Natural Science Foundation of
   China (82101607),Shanghai Sailing Program (20YF1458300), Opening Project
   of Hubei Key Laboratory of Cognitive and Affective
   Disorders(HBCAD2024-04), and Research Project for Basic Medicine
   (MS2024005)
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NR 51
TC 1
Z9 1
U1 0
U2 0
PU ASSOC BASIC MEDICAL SCI FEDERATION BOSNIA & HERZEGOVINA SARAJEVO
PI CEKALUSA
PA UNIV SARAJEVO, MEDICAL FAC, CEKALUSA, SARAJEVO 90, BOSNIA & HERCEG
SN 2831-0896
EI 2831-090X
J9 BIOMOL BIOMED
JI Biomol. Biomed.
PD 2025 JAN 15
PY 2025
DI 10.17305/bb.2024.11800
EA JAN 2025
PG 26
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA S7B7U
UT WOS:001399736800001
PM 39834212
OA gold
DA 2025-06-11
ER

PT J
AU Perazzo, H
   Poynard, T
   Dufour, JF
AF Perazzo, Hugo
   Poynard, Thierry
   Dufour, Jean-Francois
TI The Interactions of Nonalcoholic Fatty Liver Disease and Cardiovascular
   Diseases
SO CLINICS IN LIVER DISEASE
LA English
DT Article
DE Nonalcoholic fatty liver disease; Liver fibrosis; Cardiovascular
   disease; Atherosclerosis; Insulin resistance
ID GAMMA-GLUTAMYL-TRANSFERASE; CORONARY-HEART-DISEASE; INTIMA-MEDIA
   THICKNESS; CAROTID-ARTERY INTIMA; FRAMINGHAM RISK SCORE; TERM-FOLLOW-UP;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; LONG-TERM; HEPATIC STEATOSIS
AB A complex interaction among metabolic factors, adipose tissue lipolysis, oxidative stress, and insulin resistance results in a deleterious process that may link nonalcoholic fatty liver disease (NAFLD) with severe cardiovascular (CV) outcomes. Patients with NAFLD are at higher risk of atherosclerosis, new onset of CV events, and overall mortality. The strong association between NAFLD and CV disease should affect clinical practice, with screening and surveillance of patients with NAFLD. This review discusses the data linking these major diseases.
C1 [Perazzo, Hugo; Poynard, Thierry] Grp Hosp Pitie Salpetriere, AP HP, Ctr Liver, Hepatol Dept, F-75013 Paris, France.
   [Perazzo, Hugo; Poynard, Thierry] Univ Paris 06, INSERM, UMR S 938, Paris, France.
   [Poynard, Thierry] Inst Cardiometab & Nutr, Paris, France.
   [Dufour, Jean-Francois] Univ Bern, Inselspital, Univ Clin Visceral Surg & Med, CH-3010 Bern, Switzerland.
   [Dufour, Jean-Francois] Univ Bern, Dept Clin Res, CH-3010 Bern, Switzerland.
C3 Assistance Publique Hopitaux Paris (APHP); Hopital Universitaire
   Pitie-Salpetriere - APHP; Sorbonne Universite; Institut National de la
   Sante et de la Recherche Medicale (Inserm); Sorbonne Universite;
   Sorbonne Universite; University of Bern; University Hospital of Bern;
   University of Bern
RP Dufour, JF (corresponding author), Univ Bern, Inselspital, Univ Clin Visceral Surg & Med, Freiburgstr, CH-3010 Bern, Switzerland.
EM jean-francois.dufour@ikp.unibe.ch
RI Poynard, Thierry/C-1355-2010; Dufour, Jean/AAL-9866-2020
OI Dufour, Jean-Francois/0000-0002-8062-1346; Perazzo,
   Hugo/0000-0003-0931-6418; , Poynard/0000-0002-3726-7230
FU European Union [Health-F2-2009-241762]; Institute of Cardiometabolism
   and Nutrition (ICAN); MESR [2011-2016]; Association pour la Recherche
   sur les Maladies Hepatiques Virales (ARMHV)
FX This study was supported by the European Union Seventh Framework
   Programme (FP7/2007-2013) under grant agreement no
   Health-F2-2009-241762, for the project FLIP; the Institute of
   Cardiometabolism and Nutrition (ICAN) funded by MESR 2011-2016 and the
   Association pour la Recherche sur les Maladies Hepatiques Virales
   (ARMHV). These sponsors played no role in the interpretation of data.
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NR 89
TC 18
Z9 18
U1 2
U2 16
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 1089-3261
EI 1557-8224
J9 CLIN LIVER DIS
JI Clin. Liver Dis.
PD FEB
PY 2014
VL 18
IS 1
BP 233
EP +
DI 10.1016/j.cld.2013.09.014
PG 17
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 278VL
UT WOS:000328917900018
PM 24274877
DA 2025-06-11
ER

PT J
AU Denova-Gutiérrez, E
   Flores, YN
   Gallegos-Carrillo, K
   Ramírez-Palacios, P
   Rivera-Paredez, B
   Muñoz-Aguirre, P
   Velázquez-Cruz, R
   Torres-Ibarra, L
   Meneses-León, J
   Méndez-Hernández, P
   Hernández-López, R
   Salazar-Martínez, E
   Talavera, JO
   Tamayo, J
   Castañón, S
   Osuna-Ramírez, I
   León-Maldonado, L
   Flores, M
   Macías, N
   Antúnez, D
   Huitrón-Bravo, G
   Salmerón, J
AF Denova-Gutierrez, Edgar
   Flores, Yvonne N.
   Gallegos-Carrillo, Katia
   Ramirez-Palacios, Paula
   Rivera-Paredez, Berenice
   Munoz-Aguirre, Paloma
   Velazquez-Cruz, Rafael
   Torres-Ibarra, Leticia
   Meneses-Leon, Joacim
   Mendez-Hernandez, Pablo
   Hernandez-Lopez, Rubi
   Salazar-Martinez, Eduardo
   Talavera, Juan O.
   Tamayo, Juan
   Castanon, Susana
   Osuna-Ramirez, Ignacio
   Leon-Maldonado, Leith
   Flores, Mario
   Macias, Nayeli
   Antunez, Daniela
   Huitron-Bravo, Gerardo
   Salmeron, Jorge
TI Health workers cohort study: methods and study design
SO SALUD PUBLICA DE MEXICO
LA English
DT Article
DE cohort studies; characteristics; study population; Mexico
ID DIETARY PATTERNS; PHYSICAL-ACTIVITY; METABOLIC SYNDROME;
   CARDIOVASCULAR-DISEASE; RISK; ASSOCIATION; MEXICO; OBESITY;
   QUESTIONNAIRE; DEPRESSION
AB Objective. To examine different health outcomes that are associated with specific lifestyle and genetic factors. Materials and methods. From March 2004 to April 2006, a sample of employees from three different health and academic institutions, as well as their family members, were enrolled in the study after providing informed consent. At baseline and follow-up (2010-2013), participants completed a self-administered questionnaire, a physical examination, and provided blood samples. Results.A total of 10 729 participants aged 6 to 94 years were recruited at baseline. Of these, 70% were females, and 50% were from the Mexican Social Security Institute. Nearly 42% of the adults in the sample were overweight, while 20% were obese. Conclusion. Our study can offer new insights into disease mechanisms and prevention through the analysis of risk factor information in a large sample of Mexicans.
C1 [Denova-Gutierrez, Edgar] Hosp Infantil Mexico Dr Federico Gomez, Unidad Invest Epidemiol Clin, Mexico City, DF, Mexico.
   [Flores, Yvonne N.; Gallegos-Carrillo, Katia; Ramirez-Palacios, Paula; Rivera-Paredez, Berenice; Munoz-Aguirre, Paloma; Meneses-Leon, Joacim; Hernandez-Lopez, Rubi; Castanon, Susana; Antunez, Daniela; Salmeron, Jorge] Inst Mexicano Seguro Social, Unidad Invest Epidemiol & Serv Salud, Blvd Benito Juarez 3 Col Ctr, Cuernavaca 62000, Morelos, Mexico.
   [Flores, Yvonne N.] Univ Calif Los Angeles, Dept Hlth Policy & Management, Fielding Sch Publ Hlth, Los Angeles, CA USA.
   [Flores, Yvonne N.] Jonsson Comprehens Canc Ctr, Los Angeles, CA 90034 USA.
   [Velazquez-Cruz, Rafael] Inst Nacl Med Genom, Lab Genom Metab Oseo, Mexico City, DF, Mexico.
   [Torres-Ibarra, Leticia; Salazar-Martinez, Eduardo; Leon-Maldonado, Leith; Salmeron, Jorge] Inst Nacl Salud Publ, Ctr Invest Salud Poblac, Cuernavaca, Morelos, Mexico.
   [Mendez-Hernandez, Pablo] Univ Autonoma Tlaxcala, Fac Ciencias Salud, Tlaxcala, Mexico.
   [Mendez-Hernandez, Pablo] Secretaria Salud Tlaxcala, Tlaxcala, Mexico.
   [Talavera, Juan O.] Hosp Especialidades CMN SXXI, Inst Mexicano Seguro Social, Ctr Adiestramiento & Invest Clin, Mexico City, DF, Mexico.
   [Tamayo, Juan] Com Mexicano Prevent Osteoporosis, Mexico City, DF, Mexico.
   [Osuna-Ramirez, Ignacio] Univ Autonoma Sinaloa, Fac Ciencias Quim Biol, Culiacan, Sinaloa, Mexico.
   [Flores, Mario; Macias, Nayeli] Inst Nacl Salud Publ, Ctr Invest Nutr & Salud, Cuernavaca, Morelos, Mexico.
   [Huitron-Bravo, Gerardo] Univ Autonoma Estado Mexico, Fac Med, Toluca, Mexico.
C3 Hospital Infantil de Mexico Federico Gomez; Instituto Mexicano del
   Seguro Social; University of California System; University of California
   Los Angeles; UCLA Jonsson Comprehensive Cancer Center; Instituto
   Nacional de Medicina Genomica; Instituto Nacional de Salud Publica;
   Instituto Mexicano del Seguro Social; Universidad Autonoma de Sinaloa;
   Instituto Nacional de Salud Publica
RP Salmerón, J (corresponding author), Inst Mexicano Seguro Social, Unidad Invest Epidemiol & Serv Salud, Blvd Benito Juarez 3 Col Ctr, Cuernavaca 62000, Morelos, Mexico.
EM jorge.salmec@gmail.com
RI Edgar, Denova-Gutiérrez/HLW-7955-2023; Hernández, Pablo/AAH-8598-2020;
   RAMIREZ, PAULA/KFB-3996-2024; Huitron, Gerardo/KVC-3091-2024;
   Velazquez-Cruz, Rafael/AAC-3710-2021; León-Maldonado,
   Leith/AAH-7161-2020; Rivera-Paredez, Berenice/AAF-5745-2020
OI Ramirez-Palacios, Paula/0000-0002-2586-4396; OSUNA RAMIREZ,
   IGNACIO/0000-0002-4419-0710; Salmeron, Jorge/0000-0002-5113-299X;
   Leon-Maldonado, Leith/0000-0003-2106-206X; Macias,
   Nayeli/0000-0003-2268-9622; Flores, Yvonne N./0000-0002-0601-357X;
   Flores, Mario/0000-0001-5522-6849; Meneses Leon,
   Joacim/0000-0003-4217-1521
FU Consejo Nacional de Ciencia y Tecnologia [7876, 87783, 262233, 26267M,
   SALUD-2010-1-139796, CB-2013-01-221628, SALUD-201-01-161930]
FX The Health Workers Cohort Study is supported by the grants: Consejo
   Nacional de Ciencia y Tecnologia (grants: 7876, 87783, 262233, 26267M,
   SALUD-2010-1-139796, CB-2013-01-221628, SALUD-201-01-161930).
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NR 43
TC 71
Z9 71
U1 0
U2 15
PU INST NACIONAL SALUD PUBLICA
PI CUERNAVACA
PA AV UNIVERSIDAD 655, COL SANTA MARIA AHUACATITLAN, CUERNAVACA 62508,
   MORELOS, MEXICO
SN 0036-3634
EI 1606-7916
J9 SALUD PUBLICA MEXICO
JI Salud Publica Mexico
PD NOV-DEC
PY 2016
VL 58
IS 6
BP 708
EP 716
DI 10.21149/spm.v58i6.8299
PG 9
WC Public, Environmental & Occupational Health
WE Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA EH3CF
UT WOS:000391646000026
PM 28225947
OA Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Koehler, E
   Watt, K
   Charlton, M
AF Koehler, Edith
   Watt, Kymberly
   Charlton, Michael
TI Fatty Liver and Liver Transplantation
SO CLINICS IN LIVER DISEASE
LA English
DT Article
DE Fatty liver disease; Steatohepatitis; Cirrhosis; Liver transplantation;
   Metabolic syndrome; Obesity
ID Y GASTRIC BYPASS; NONALCOHOLIC STEATOHEPATITIS; CRYPTOGENIC CIRRHOSIS;
   OBESE-PATIENTS; URSODEOXYCHOLIC ACID; INSULIN-RESISTANCE; HEPATIC
   STEATOSIS; BARIATRIC SURGERY; OXIDATIVE STRESS; CONTROLLED-TRIAL
AB Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis are common complications of overnutrition and obesity. In the setting of worsening epidemics of obesity in developed and developing countries, the global prevalence and impact of NAFLD seems likely to increase. The large number of patients at risk will translate into major challenges for the liver transplant community, affecting donors and recipients. The comorbidities and hepatic effects of obesity and NAFLD present important new challenges in the management of donors and recipients. This article addresses some of these challenges.
C1 [Koehler, Edith; Watt, Kymberly; Charlton, Michael] Mayo Clin, Mayo Clin & Fdn, Transplant Ctr, Dept Gastroenterol & Hepatol, Rochester, MN 55905 USA.
C3 Mayo Clinic
RP Charlton, M (corresponding author), Mayo Clin, Mayo Clin & Fdn, Transplant Ctr, Dept Gastroenterol & Hepatol, CH-10,200 1st St, Rochester, MN 55905 USA.
EM charlton.michael@mayo.edu
RI Watt, Kymberly/D-5359-2017
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NR 58
TC 29
Z9 35
U1 1
U2 7
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 1089-3261
EI 1557-8224
J9 CLIN LIVER DIS
JI Clin. Liver Dis.
PD NOV
PY 2009
VL 13
IS 4
BP 621
EP +
DI 10.1016/j.cld.2009.07.010
PG 11
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 514JJ
UT WOS:000271390100009
PM 19818309
DA 2025-06-11
ER

PT J
AU Souza-Pereira, A
   Hernandez, MD
   Guerra, JMD
   Nieswald, BH
   Bianchini, MC
   Godinho, DB
   Nascimento, AS
   Puntel, RL
   Royes, LFF
   Rambo, LM
AF Souza-Pereira, Adson
   Hernandez, Mariele da Silva
   Guerra, Jozye Milena da Silva
   Nieswald, Bruno Henrique
   Bianchini, Matheus Chimelo
   Godinho, Douglas Buchmann
   Nascimento, Alexandre Seixas
   Puntel, Robson Luiz
   Royes, Luiz Fernando Freire
   Rambo, Leonardo Magno
TI Swimming training and caffeine supplementation protects against
   metabolic syndrome-induced nuclear factor-KB activation and cognitive
   deficits in rats
SO NUTRITION RESEARCH
LA English
DT Article
DE Memory; Metabolism; Anxiety; Immunoblotting; physical exercise; NRF2
ID INDUCED INSULIN-RESISTANCE; HIGH-FAT DIET; DIABETES-MELLITUS;
   PHYSICAL-ACTIVITY; BLOOD-PRESSURE; EXERCISE; BRAIN; DAMAGE; RISK;
   HYPERTENSION
AB Metabolic syndrome (MS) is a disorder that increasingly affects the world population, mainly because of changes in lifestyle and dietary habits. In this regard, both physical exercise and caffeine are low-cost and easily accessible therapies that separately have shown positive effects against metabolic disorders. Therefore, we hypothesized that physical exercise combined with caffeine could have a synergistic effect in the treatment of MS, risk factors, and cognitive deficits. Animals were divided into 8 groups and received fructose (15% w/v) or vehicle for 10 weeks. Swimming training and caffeine (6 mg/kg) started 4 weeks after fructose administration. Trained animals presented decreased body weight and visceral fat mass and increased soleus weight compared with untrained fructose-treated animals. Caffeine supplementation also prevented the gain of visceral fat mass induced by fructose. Furthermore, both treatments reversed fructose-induced decrease in glucose clearance over time and fructose-induced increase in 4-hydroxynonenal and nuclear factor -KB immunoreactivity. Physical training also improved the lipidic profile in fructose-treated animals (high-density lipoprotein, low-density lipoprotein, and triglycerides), improved short-term, long-term, and localization memory, and reversed the fructose-induced deficit in short-term memory. Physical training also increased nuclear factor erythroid 2-related factor 2 immunoreactivity perse . Considering that physical training and caffeine reversed some of the damages induced by fructose it is plausible to consider these treatments as alternative, nonpharmacological, and low-cost therapies to help reduce MS-associated risk factors; however, combined treatments did not show additive effects as hypothesized.(c) 2023 Elsevier Inc. All rights reserved.
C1 [Souza-Pereira, Adson; Hernandez, Mariele da Silva; Guerra, Jozye Milena da Silva; Nieswald, Bruno Henrique; Bianchini, Matheus Chimelo; Puntel, Robson Luiz; Rambo, Leonardo Magno] Fed Univ Pampa, Biochem Grad Program, Uruguaiana, RS, Brazil.
   [Godinho, Douglas Buchmann; Nascimento, Alexandre Seixas; Royes, Luiz Fernando Freire] Univ Fed Santa Maria, Dept Methods & Sport Tech, Santa Maria, RS, Brazil.
   [Rambo, Leonardo Magno] Fed Univ Pampa, Biochem Grad Program, BR-97500970 Uruguaiana, RS, Brazil.
C3 Universidade Federal do Pampa; Universidade Federal de Santa Maria
   (UFSM); Universidade Federal do Pampa
RP Rambo, LM (corresponding author), Fed Univ Pampa, Biochem Grad Program, BR-97500970 Uruguaiana, RS, Brazil.
EM leonardorambo@unipampa.edu.br
RI royes, luiz/T-3581-2019; Rambo, Leonardo/F-8195-2012; BIANCHINI,
   MATHEUS/AEI-5035-2022
OI Seixas Nascimento, Alexandre/0000-0002-5588-4558; BIANCHINI,
   MATHEUS/0000-0002-7024-775X; Rambo, Leonardo Magno/0000-0002-4769-3663;
   Buchmann Godinho, Douglas/0000-0002-7674-3025
FU Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
   [307382/2017-6]
FX This study was supported by Conselho Nacional de Desenvolvimento
   Cientifico e Tecnologico (CNPq no. 307382/2017-6 for L.F.R.) .
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NR 63
TC 0
Z9 0
U1 0
U2 0
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0271-5317
EI 1879-0739
J9 NUTR RES
JI Nutr. Res.
PD FEB
PY 2024
VL 122
BP 19
EP 32
DI 10.1016/j.nutres.2023.11.002
EA DEC 2023
PG 14
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA DV9G0
UT WOS:001134968100001
PM 38070463
DA 2025-06-11
ER

PT J
AU Yan, A
   Xie, GN
   Ding, XY
   Wang, Y
   Guo, LP
AF Yan, An
   Xie, Guinan
   Ding, Xinya
   Wang, Yi
   Guo, Liping
TI Effects of Lipid Overload on Heart in Metabolic Diseases
SO HORMONE AND METABOLIC RESEARCH
LA English
DT Review
DE lipid metabolism; cardiac energy metabolism; metabolic diseases;
   metabolic syndrome; type 2 diabetes; diabetic cardiomyopathy
ID FATTY-ACID-METABOLISM; INSULIN-RESISTANCE; DIABETIC CARDIOMYOPATHY;
   CONTRACTILE DYSFUNCTION; DIASTOLIC DYSFUNCTION; OXIDATIVE STRESS;
   INHIBITION; DIET; ATHEROSCLEROSIS; PHOSPHORYLATION
AB Metabolic diseases are often associated with lipid and glucose metabolism abnormalities, which increase the risk of cardiovascular disease. Diabetic cardiomyopathy (DCM) is an important development of metabolic diseases and a major cause of death. Lipids are the main fuel for energy metabolism in the heart. The increase of circulating lipids affects the uptake and utilization of fatty acids and glucose in the heart, and also affects mitochondrial function. In this paper, the mechanism of lipid overload in metabolic diseases leading to cardiac energy metabolism disorder is discussed.
C1 [Yan, An; Xie, Guinan; Ding, Xinya; Wang, Yi] Tianjin Univ Tradit Chinese Med, Tianjin, Peoples R China.
   [Guo, Liping] Tianjin Acad Tradit Chinese Med, Tianjin 300120, Peoples R China.
C3 Tianjin University of Traditional Chinese Medicine
RP Guo, LP (corresponding author), Tianjin Acad Tradit Chinese Med, Tianjin 300120, Peoples R China.; Wang, Y (corresponding author), Tianjin Univ Tradit Chinese Med, Inst Tradit Chinese Med, Tianjin 300193, Peoples R China.
EM wangyi@tjutcm.edu.cn; lpgtjn@163.com
RI wang, yingying/JSK-6741-2023; Yan, An/JPA-0307-2023
OI Xie, Guinan/0000-0001-7428-8180
FU Tianjin Postgraduate Research and Innovation Project [2020YJSB196]
FX This work was supported by Tianjin Postgraduate Research and Innovation
   Project (2020YJSB196).
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NR 99
TC 13
Z9 15
U1 1
U2 31
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA Oswald-Hesse-Strasse 50, D-70469 STUTTGART, GERMANY
SN 0018-5043
EI 1439-4286
J9 HORM METAB RES
JI Horm. Metab. Res.
PD DEC
PY 2021
VL 53
IS 12
BP 771
EP 778
DI 10.1055/a-1693-8356
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA XM6IT
UT WOS:000728929000001
PM 34891207
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Esposito, K
   Giugliano, D
AF Esposito, K
   Giugliano, D
TI Diet and inflammation: a link to metabolic and cardiovascular diseases
SO EUROPEAN HEART JOURNAL
LA English
DT Review
DE dietary patterns; inflammation; endothelial dysfunction; insulin
   resistance; metabolic syndrome
ID POSTPRANDIAL ENDOTHELIAL DYSFUNCTION; HIGH-FAT MEAL; MEDITERRANEAN DIET;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; ASYMMETRIC DIMETHYLARGININE;
   PLASMA BIOMARKERS; HEALTHY-SUBJECTS; LIFE-STYLE; SHORT-TERM
AB Both epidemiological studies and intervention trials support an important role of diet in reducing the risk of a variety of chronic diseases, including cardiovascular disease, and overall mortality. We discuss available evidence indicating that the generation of a pro-inflammatory milieu might be one mechanism through which unhealthy diets are linked to metabolic and cardiovascular diseases. In practical terms, fully understanding the link between diet and inflammation holds the premise to elucidate the mechanisms by which dietary patterns improve cardiovascular health.
C1 Univ Naples Federico II, Policlin Univ Naples 2, Div Metab Dis, I-80138 Naples, Italy.
C3 University of Naples Federico II; Universita della Campania Vanvitelli;
   University of Campania Luigi Vanvitelli Hospital
RP Univ Naples Federico II, Policlin Univ Naples 2, Div Metab Dis, Piazza L Miraglia, I-80138 Naples, Italy.
EM dario.giugliano@unina2.it
OI Giugliano, Dario/0000-0002-9377-873X
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NR 49
TC 152
Z9 169
U1 1
U2 10
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0195-668X
EI 1522-9645
J9 EUR HEART J
JI Eur. Heart J.
PD JAN
PY 2006
VL 27
IS 1
BP 15
EP 20
DI 10.1093/eurheartj/ehi605
PG 6
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 991XO
UT WOS:000233848200008
PM 16219650
DA 2025-06-11
ER

PT J
AU Belazarian, L
AF Belazarian, Leah
TI New insights and therapies for teenage psoriasis
SO CURRENT OPINION IN PEDIATRICS
LA English
DT Review
DE adolescent; pediatric; psoriasis; teenage
ID CHILDHOOD PSORIASIS; PEDIATRIC-PATIENTS; CHILDREN; ETANERCEPT;
   PHOTOTHERAPY; CALCIPOTRIOL; ADOLESCENTS; CYCLOSPORINE; MEDICATIONS;
   DISEASE
AB Purpose of review
   Psoriasis is an important disorder in the adolescent population and has a tremendous physical and psychological impact on patients. It is important to understand the genetics, various clinical presentations, comorbidities, and treatment options associated with psoriasis.
   Recent findings The human leukocyte antigen-C gene likely contains a susceptibility locus for psoriasis. Cytokines interleukin-12 and interleukin-23 have been implicated in the pathogenesis of psoriasis as well. Psoriasis is likely associated with an increased risk of myocardial infarction, metabolic syndrome, Crohn's disease, and depression; it is difficult to assess the implications in the adolescent population.
   Summary Psoriasis is not rare in the adolescent population. It is important for physicians to be aware of the different clinical presentations as well as the spectrum of treatment options that are available.
C1 Univ Massachusetts, Sch Med, Worcester, MA 01605 USA.
C3 University of Massachusetts System; University of Massachusetts
   Worcester
RP Belazarian, L (corresponding author), Univ Massachusetts, Sch Med, 281 Lincoln St, Worcester, MA 01605 USA.
EM Belazl0l@ummhc.org
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NR 36
TC 3
Z9 3
U1 0
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1040-8703
EI 1531-698X
J9 CURR OPIN PEDIATR
JI CURR. OPIN. PEDIATR.
PD AUG
PY 2008
VL 20
IS 4
BP 419
EP 424
DI 10.1097/MOP.0b013e328305e24b
PG 6
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA 331PM
UT WOS:000258024400009
PM 18622197
DA 2025-06-11
ER

PT J
AU Carlin, BW
AF Carlin, Brian W.
TI COPD and Associated Comorbidities: A Review of Current Diagnosis and
   Treatment
SO POSTGRADUATE MEDICINE
LA English
DT Article
DE COPD; comorbidities; pulmonary rehabilitation; adherence;
   patient-centered medical home
ID OBSTRUCTIVE PULMONARY-DISEASE; BODY-MASS INDEX; QUALITY-OF-LIFE;
   PRIMARY-CARE; HEART-FAILURE; GASTROESOPHAGEAL-REFLUX;
   CARDIOVASCULAR-DISEASE; ELDERLY-PATIENTS; HEALTH-STATUS; RISK
AB Health care utilization and costs associated with chronic obstructive pulmonary disease (COPD) continue to increase, notwithstanding evidence-based management strategies described by major respiratory societies. Cardiovascular diseases, asthma, diabetes and its precursors (obesity and metabolic syndrome), depression, cognitive impairment, and osteoporosis arc examples of common comorbidities that can affect or be affected by COPD. Appropriate diagnosis and management (from a pharmacologic and nonpharmacologic perspective) of COPD and its associated comorbidities are important to ensure optimal patient care. An evolving understanding of COPD as a multimorbid disease that affects an aging population, rather than just a lung-specific disease, necessitates an integrated, tailored disease-management approach to improve prognoses and reduce costs.
C1 [Carlin, Brian W.] Drexel Univ, Sch Med, Allegheny Gen Hosp, Pittsburgh, PA USA.
C3 Drexel University; Allegheny Health Network; Allegheny General Hospital
RP Carlin, BW (corresponding author), Sleep Med & Lung Hlth Consultants, POB 174, Ingomar, PA 15127 USA.
EM bwcmd@yahoo.com
FU Boehringer Ingelheim Pharmaceuticals, Inc; Pfizer Inc.
FX Manuscript preparation, including medical writing assistance, which was
   provided by Zeena Nackerdien, PhD and Kim Coleman Healy, PhD, of
   Envision Scientific Solutions, was supported by Boehringer Ingelheim
   Pharmaceuticals, Inc and Pfizer Inc. The article reflects the concepts
   of the author and is the author's sole responsibility. It was not
   reviewed by Boehringer Ingelheim Pharmaceuticals, Inc and Pfizer Inc,
   except to ensure medical and safety accuracy. The author received no
   compensation for manuscript development.
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NR 113
TC 22
Z9 27
U1 0
U2 16
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0032-5481
EI 1941-9260
J9 POSTGRAD MED
JI Postgrad. Med.
PD JUL
PY 2012
VL 124
IS 4
BP 225
EP 240
DI 10.3810/pgm.2012.07.2582
PG 16
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 984OW
UT WOS:000307201700023
PM 22913911
DA 2025-06-11
ER

PT J
AU Fischer, CW
   Elfving, B
   Lund, S
   Wegener, G
AF Fischer, Christina W.
   Elfving, Betina
   Lund, Sten
   Wegener, Gregers
TI Behavioral and systemic consequences of long-term inflammatory challenge
SO JOURNAL OF NEUROIMMUNOLOGY
LA English
DT Article
DE Cytokines; Sickness behavior; Depression-like behavior;
   Lipopolysaccharide
ID TUMOR-NECROSIS-FACTOR; INSULIN-RESISTANCE; INDOLEAMINE 2,3-DIOXYGENASE;
   ENDOTOXIN TOLERANCE; METABOLIC SYNDROME; SICKNESS BEHAVIOR;
   INTERFERON-GAMMA; TNF-ALPHA; BRAIN; LIPOPOLYSACCHARIDE
AB Inflammatory reactions are involved in a diversity of diseases, including major depressive disorder. Cytokines act as intercellular signaling molecules and mediators of inflammation between the periphery and the brain. Within the brain, evidence from animal studies of acute inflammation has shown that elevated cytokine levels are linked to behavioral responses of sickness and depression-like behavior. Although chronic inflammation is more translational to human depression than acute studies, little is known on central cytokine expression and associated behavioral responses following chronic immune challenges.
   The present study assessed behavioral changes and a selection of cytokines in the brain and in the blood in rats randomized to receive a single or 8 week administration with either lipopolysaccharide (LPS, 600 mu g/kg, i.p.) or saline.
   Acute and long-term LPS treatments caused similar sickness and depression-like behavior. Chronic LPS administration did not have an effect on blood cytokine levels, indicating endotoxin tolerance, whereas increased fasting blood glucose was observed, indicating insulin resistance, a metabolic consequence of chronic inflammation. While a single LPS injection produced a generalized cytokine response in the brain, long-term LPS administration produced a specific central cytokine response with increased interleukin (IL)-1 beta and interferon (IFN)-gamma. These cytokines can explain the behavioral changes observed, and could indicate microglia activation, although future studies are needed to uncover this assumption.
   Taken together, although the behavioral outcome was similar between acute and chronic LPS administration, the central cytokine response was distinct As the long-term LPS paradigm also posed a metabolic demand, this setting may reflect a more translational insight into inflammatory reactions in human depression, and could prove useful for assessing cytokine down-stream effects and experimental antidepressant drug products. (C) 2015 Elsevier B.V. All rights reserved.
C1 [Fischer, Christina W.; Elfving, Betina; Wegener, Gregers] Aarhus Univ, Translat Neuropsychiat Unit, DK-8240 Risskov, Denmark.
   [Lund, Sten] Aarhus Univ Hosp, Dept Internal Med & Endocrinol, DK-8000 Aarhus, Denmark.
C3 Aarhus University; Aarhus University
RP Fischer, CW (corresponding author), Skovagervej 2, DK-8240 Risskov, Denmark.
EM Christinawfischer@gmail.com; betina.elfving@clin.au.dk; SL@dadlnet.dk;
   wegener@dadlnet.dk
RI Elfving, Betina/H-2814-2019; Wegener, Gregers/A-1019-2011
OI Elfving, Betina/0000-0001-6939-5088; Lund, Sten/0000-0002-3805-6267;
   Wegener, Gregers/0000-0002-0081-0068
FU Aase og Ejnar Danielsens fond [10-001080]; Henry Hansen og hustru Karla
   Hansen fodt Westergaards Legat [16163008]
FX This project is funded by Aase og Ejnar Danielsens fond (10-001080) and
   Henry Hansen og hustru Karla Hansen fodt Westergaards Legat (16163008).
   We would like to thank Cecilie Bay-Richter for helpful discussions.
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NR 42
TC 34
Z9 34
U1 0
U2 18
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0165-5728
EI 1872-8421
J9 J NEUROIMMUNOL
JI J. Neuroimmunol.
PD NOV 15
PY 2015
VL 288
BP 40
EP 46
DI 10.1016/j.jneuroim.2015.08.011
PG 7
WC Immunology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Neurosciences & Neurology
GA CW5PV
UT WOS:000365049800006
PM 26531693
DA 2025-06-11
ER

PT J
AU Lentine, T
   Johnson, Q
   Lockie, R
   Joyce, J
   Orr, R
   Dawes, J
AF Lentine, Tim
   Johnson, Quincy
   Lockie, Robert
   Joyce, Jill
   Orr, Rob
   Dawes, Jay
TI Occupational Challenges to the Development and Maintenance of Physical
   Fitness Within Law Enforcement Officers
SO STRENGTH AND CONDITIONING JOURNAL
LA English
DT Article
ID METABOLIC SYNDROME; POLICE OFFICERS; RISK-FACTORS; WORK HOURS;
   SHIFTWORK; DISEASE; OBESITY; STRESS
AB Law enforcement officers must perform physically demanding tasks as part of their job duties. Consequently, law enforcement officers must possess an adequate level of physical fitness to perform these activities safely and effectively. Ironically, most of an officer's shift time is sedentary. This, in addition to other occupational challenges, may make it difficult for officers to develop and maintain fitness across the occupational life span. This is concerning when considering that physical fitness is associated with their occupational task performance. In this column, the unique challenges law enforcement officers experience when trying to maintain health and occupational fitness are discussed.
C1 [Lentine, Tim] 4th Infantry Div, World Class Athlete Program, Ft Carson, CA USA.
   [Lentine, Tim] 4th Infantry Div, Ft Carson, CA USA.
   [Lentine, Tim] 759th Mil Police, Ft Carson, CA USA.
   [Johnson, Quincy] Oklahoma State Univ, Sch Kinesiol Appl Hlth & Recreat, Stillwater, OK 74078 USA.
   [Lockie, Robert] Calif State Univ Fullerton, Strength & Conditioning, Fullerton, CA 92634 USA.
   [Joyce, Jill] Oklahoma State Univ, Dept Nutr Sci, Publ Hlth Nutr, Stillwater, OK 74078 USA.
   [Orr, Rob] Bond Univ, Fac Hlth Sci & Med, Southport, Qld, Australia.
   [Dawes, Jay] Sch Kinesiol Appl Hlth & Recreat, Appl Exercise Sci, Stillwater, OK 74078 USA.
C3 Oklahoma State University System; Oklahoma State University -
   Stillwater; California State University System; California State
   University Fullerton; Oklahoma State University System; Oklahoma State
   University - Stillwater; Bond University
RP Dawes, J (corresponding author), Sch Kinesiol Appl Hlth & Recreat, Appl Exercise Sci, Stillwater, OK 74078 USA.
EM jay.dawes@okstate.edu
RI Orr, Robin/H-3757-2019; Dawes, Jay/K-9645-2019
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NR 38
TC 5
Z9 5
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1524-1602
EI 1533-4295
J9 STRENGTH COND J
JI Strength Cond. J.
PD DEC
PY 2021
VL 43
IS 6
BP 115
EP 118
PG 4
WC Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Sport Sciences
GA XL7CU
UT WOS:000728300600013
DA 2025-06-11
ER

PT J
AU Cheung, BMY
   Li, C
AF Cheung, Bernard M. Y.
   Li, Chao
TI Diabetes and Hypertension: Is There a Common Metabolic Pathway?
SO CURRENT ATHEROSCLEROSIS REPORTS
LA English
DT Article
DE Diabetes; Hypertension; Obesity; Metabolic syndrome; Metabolic pathway;
   Insulin resistance
ID IMPAIRED GLUCOSE-TOLERANCE; SYMPATHETIC-NERVE ACTIVITY; GENOME-WIDE
   ASSOCIATION; C-REACTIVE PROTEIN; HONG-KONG CHINESE; BLOOD-PRESSURE;
   INSULIN-RESISTANCE; ANGIOTENSIN-II; PHYSICAL-ACTIVITY;
   CARDIOVASCULAR-DISEASE
AB Diabetes and hypertension frequently occur together. There is substantial overlap between diabetes and hypertension in etiology and disease mechanisms. Obesity, inflammation, oxidative stress, and insulin resistance are thought to be the common pathways. Recent advances in the understanding of these pathways have provided new insights and perspectives. Physical activity plays an important protective role in the two diseases. Knowing the common causes and disease mechanisms allows a more effective and proactive approach in their prevention and treatment.
C1 [Cheung, Bernard M. Y.] Queen Mary Hosp, Dept Med, Hong Kong, Hong Kong, Peoples R China.
   [Cheung, Bernard M. Y.; Li, Chao] Univ Hong Kong, Dept Med, Hong Kong, Hong Kong, Peoples R China.
C3 University of Hong Kong; University of Hong Kong
RP Cheung, BMY (corresponding author), Queen Mary Hosp, Dept Med, 102 Pokfulam Rd, Hong Kong, Hong Kong, Peoples R China.
EM mycheung@hku.hk; dcli@hku.hk
RI Li, Chao/E-6186-2012; /E-9829-2010
OI /0000-0001-9106-7363
FU Li Ka Shing Faculty of Medicine, University of Hong Kong
FX BMY Cheung received support from the Faculty Research Fund, Li Ka Shing
   Faculty of Medicine, University of Hong Kong.
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NR 114
TC 394
Z9 440
U1 1
U2 38
PU CURRENT MEDICINE GROUP
PI PHILADELPHIA
PA 400 MARKET STREET, STE 700, PHILADELPHIA, PA 19106 USA
SN 1523-3804
EI 1534-6242
J9 CURR ATHEROSCLER REP
JI Curr. Atheroscleros. Rep.
PD APR
PY 2012
VL 14
IS 2
BP 160
EP 166
DI 10.1007/s11883-012-0227-2
PG 7
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 918OT
UT WOS:000302260500010
PM 22281657
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Oliva-Olivera, W
   Moreno-Indias, I
   Coín-Aragüez, L
   Lhamyani, S
   Torres, JA
   Fernández-Veledo, S
   Vendrell, J
   Camargo, A
   El Bekay, R
   Tinahones, FJ
AF Oliva-Olivera, Wilfredo
   Moreno-Indias, Isabel
   Coin-Araguez, Leticia
   Lhamyani, Said
   Alcaide Torres, Juan
   Fernandez-Veledo, Sonia
   Vendrell, Joan
   Camargo, Antonio
   El Bekay, Rajaa
   Jose Tinahones, Francisco
TI Different response to hypoxia of adipose-derived multipotent cells from
   obese subjects with and without metabolic syndrome
SO PLOS ONE
LA English
DT Article
ID IMPROVE POSTNATAL NEOVASCULARIZATION; MESENCHYMAL STEM-CELLS;
   INSULIN-RESISTANCE; STROMAL CELLS; MACROPHAGE INFILTRATION; TISSUE
   ANGIOGENESIS; ENDOTHELIAL-CELLS; OXIDATIVE STRESS; PROGENITOR CELLS;
   INFLAMMATION
AB Background/Objectives
   Multiple studies suggest that hypoxia, together with inflammation, could be one of the phenomena involved in the onset and progression of obesity-related insulin resistance. In addition, dysfunction of adipose tissue in obese subjects with metabolic syndrome is associated with decreased angiogenesis. However, some subjects with a high body mass index do not develop metabolic abnormalities associated with obesity. The aim of the current study was to examine the neovascular properties of visceral adipose tissue-derived multipotent mesenchymal cells subjected to hypoxia (hypox-visASCs) from normal-weight subjects (Nw) and obese patients with metabolic syndrome (MS) and without metabolic syndrome (NonMS).
   Methods
   This was a 2-year study to enroll subjects who underwent bariatric surgery or cholecystectomy. Eight patients who underwent either bariatric surgery or cholecystectomy (27 patients) participated in the study. Visceral adipose tissue samples from Nw, MS and NonMS subjects were processed by enzymatic digestion. VisASCs cultured under hypoxic conditions were characterized by tubule formation assay, ELISA, flow cytometry, migration rate, and qRT-PCR, and the effects of visASCs-conditioned medium on survival and endothelial cell tubule formation were evaluated.
   Results
   Hypox-visASCs from NonMS subjects showed a greater capacity for tubule formation than hypox-visASCs from Nw and MS subjects. The lower percentage of CD140b(+)/CD44(+) and CD140b(+)/CD184(+) cells observed in hypox-visASCs from NonMS subjects compared to MS subjects was accompanied not only by a lower migration rate from the chemotactic effects of stromal cell derived factor 1 alpha, but also by lower levels of NOX5 mRNA expression. While the levels of monocyte chemoattractant protein 1 mRNA expressed by hypox-visASCs correlated positively with the body mass index and waist circumference of the subjects, the concentration of vascular endothelial growth factor present in hypox-visASC-conditioned culture medium decreased significantly with increasing plasma glucose. The survival rate and tubules formed by endothelial cells cultured in hypox-visASC-conditioned medium decreased significantly with increasing homeostasis model assessment to quantify insulin resistance.
   Conclusions
   Our results suggest that hypox-visASCs from NonMS subjects could promote healthy adipose tissue expansion, while hypox-visASCs from MS subjects appear to contribute to the decreased angiogenic potential and increased inflammation underlying adipose tissue dysfunction in obesity. Our results emphasize the importance of taking into account not only the BMI but also the metabolic profile of the subjects during the implementation of ASCs-based therapy to promote neovascularization.
C1 [Oliva-Olivera, Wilfredo; Moreno-Indias, Isabel; Coin-Araguez, Leticia; Alcaide Torres, Juan; El Bekay, Rajaa; Jose Tinahones, Francisco] Univ Malaga UMA, Hosp Malaga Virgen de la Victoria, Dept Clin Endocrinol & Nutr, Inst Biomed Res Malaga IBIMA, Malaga, Spain.
   [Oliva-Olivera, Wilfredo; Moreno-Indias, Isabel; Coin-Araguez, Leticia; Alcaide Torres, Juan; Camargo, Antonio; El Bekay, Rajaa; Jose Tinahones, Francisco] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nut, Madrid, Spain.
   [Lhamyani, Said] Univ Malaga UMA, Res Lab, Sci Sch, Malaga, Spain.
   [Fernandez-Veledo, Sonia; Vendrell, Joan] Univ Rovirai Virgili, Hosp Univ Tarragona Joan 23, Inst Invest Sanitaria Pere Virgili, Tarragona, Spain.
   [Fernandez-Veledo, Sonia; Vendrell, Joan] Inst Salud Carlos III, CIBER Diabet & Enfermedades Metab Asociadas CIBER, Madrid, Spain.
   [Camargo, Antonio] Univ Cordoba, Reina Sofia Univ Hosp, Lipids & Atherosclerosis Unit, IMIBIC, Cordoba, Spain.
C3 Instituto de Investigacion Biomedica de Malaga y Plataforma en
   Nanomedicina (IBIMA); Universidad de Malaga; Instituto de Salud Carlos
   III; Universitat Rovira i Virgili; Institut d'Investigacio Sanitaria
   Pere Virgili (IISPV); Instituto de Salud Carlos III; CIBER - Centro de
   Investigacion Biomedica en Red; CIBERES; Universidad de Cordoba
RP Oliva-Olivera, W; El Bekay, R; Tinahones, FJ (corresponding author), Univ Malaga UMA, Hosp Malaga Virgen de la Victoria, Dept Clin Endocrinol & Nutr, Inst Biomed Res Malaga IBIMA, Malaga, Spain.; Oliva-Olivera, W; El Bekay, R; Tinahones, FJ (corresponding author), Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nut, Madrid, Spain.
EM oliva_olivera@hotmail.com; elbekay@gmail.com; fjtinahones@hotmail.com
RI Tinahones, Francisco/AAB-2882-2020; LHAMYANI, said/AAQ-1973-2020; Bekay,
   Rajaa/AAZ-3959-2020; Oliva-Olivera, Wilfredo/GSN-7320-2022;
   Moreno-Indias, Isabel/B-6595-2017; Camargo Garcia, Antonio/G-9720-2015;
   Fernandez-Veledo, Sonia/V-4625-2018; Moreno-Indias, Isabel/E-8907-2011
OI Camargo Garcia, Antonio/0000-0002-0415-4184; Oliva Olivera,
   Wilfredo/0000-0003-3473-7898; Fernandez-Veledo,
   Sonia/0000-0003-2906-3788; Moreno-Indias, Isabel/0000-0002-6121-151X; El
   Bekay Rizky, RAJAA/0000-0003-3332-3431; LHAMYANI,
   said/0000-0002-9830-9772; Tinahones, Francisco J/0000-0001-6871-4403
FU European Union through the European Regional Development Fund (FEDER);
   Ministry of Economy and Competitiveness, Institute of Health Carlos III
   [PI15/01114, PI13/02628, PI12/02355]; Ministry of Economy and Knowledge
   [PI-CTS-08181/2011, CTS-7895/2011]; Fondo de Investigacion Sanitaria
   (FIS) - European Regional Development Fund (ERDF) [CP10/00438]
FX This work was cofunded by the European Union through the European
   Regional Development Fund (FEDER). The authors wish to thank all the
   participants for their collaboration. GIBER Fisiopatologia de la
   Obesidad y Nutricion (Pathophysiology of Obesity and Nutrition,
   CIBEROBN) are part of the Institute de Salud del Carlos III (Institute
   of Health Carlos III, ISCIII) Project. We would also like to thank Maria
   Repice for her help with the English language version of the text. This
   work was supported by grants from the Ministry of Economy and
   Competitiveness, Institute of Health Carlos III (PI15/01114, PI13/02628;
   PI12/02355) and the Ministry of Economy and Knowledge
   (PI-CTS-08181/2011; CTS-7895/2011). S.F.V. acknowledges support from the
   "Miguel Servet" tenure-track program (CP10/00438) from the Fondo de
   Investigacion Sanitaria (FIS) co-financed by the European Regional
   Development Fund (ERDF). R.E. is under a contract of "Nicolas Monardes"
   programme from the Servicio Andaluz de Salud, Regional Ministry of
   Health of the Andalusia Government, Andalusia, Spain.
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NR 45
TC 11
Z9 14
U1 1
U2 8
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD NOV 22
PY 2017
VL 12
IS 11
AR e0188324
DI 10.1371/journal.pone.0188324
PG 18
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA FN5GQ
UT WOS:000416035300031
PM 29166648
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Hajizadeh-Sharafabad, F
   Zahabi, ES
AF Hajizadeh-Sharafabad, Fatemeh
   Zahabi, Elham Sharifi
TI Role of alpha-lipoic acid in vascular function: A systematic review of
   human intervention studies
SO CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
LA English
DT Review
DE Alpha-lipoic acid; cardiovascular diseases; endothelial function;
   oxidative stress; vascular function
ID NF-KAPPA-B; IMPROVES ENDOTHELIAL DYSFUNCTION; NITRIC-OXIDE; OXIDATIVE
   STRESS; ASYMMETRIC DIMETHYLARGININE; DIABETIC-PATIENTS; ASCORBIC-ACID;
   ANTIOXIDANT; ACTIVATION; CELLS
AB Alpha-lipoic acid (ALA) has long been the focus of interest due to its promising effects on cardiometabolic risk factors. The aim of this systematic review was to summarize findings from existing human intervention studies evaluating the effect of ALA on vascular function. We performed a systematic search in the PubMed, SCOPUS, and Web of science electronic databases from inception until 1 July 2020. A total of 1106 records were identified from the database search, of which 12 were eligible: nine addressed chronic effects and three measured acute effects of ALA on vascular function. Of 11 trials that evaluated endothelial function by methods such as flow-mediated dilation (n = 7), reactive hyperemia (n = 2) and ACh-induced endothelium-dependent vasodilation (n = 2), 10 reported a significant improvement in endothelial function. In contrast, none of six trials examining the response of endothelium-independent vasodilation reported the favorable impact. The effect of ALA on arterial stiffness measures has been poorly studied. ALA appears to improve endothelial function through increasing the bioavailability of endothelium-derived nitric oxide as well as decreasing oxidative stress and inflammation. In conclusion, these results suggest improvement of endothelial function, but not endothelium-independent vasodilation as a potential mechanism by which ALA attenuates cardiovascular diseases.
C1 [Hajizadeh-Sharafabad, Fatemeh] Tabriz Univ Med Sci, Fac Nutr & Food Sci, Nutr Res Ctr, Dept Clin Nutr, Tabriz, Iran.
   [Hajizadeh-Sharafabad, Fatemeh] Tabriz Univ Med Sci, Fac Nutr & Food Sci, Student Res Comm, Tabriz, Iran.
   [Zahabi, Elham Sharifi] Iran Univ Med Sci, Sch Publ Hlth, Dept Nutr, Tehran, Iran.
C3 Tabriz University of Medical Science; Tabriz University of Medical
   Science; Iran University of Medical Sciences
RP Hajizadeh-Sharafabad, F (corresponding author), Tabriz Univ Med Sci, Fac Nutr & Food Sci, Dept Clin Nutr, Tabriz 5166614711, Iran.
EM fm.hajizadeh@gmail.com
RI Hajizadeh, Fatemeh/HPC-8746-2023
OI Hajizadeh-Sharafabad, Fatemeh/0000-0003-1959-5705
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NR 61
TC 9
Z9 9
U1 0
U2 11
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1040-8398
EI 1549-7852
J9 CRIT REV FOOD SCI
JI Crit. Rev. Food Sci. Nutr.
PD JUN 17
PY 2022
VL 62
IS 11
BP 2928
EP 2941
DI 10.1080/10408398.2020.1861425
EA DEC 2020
PG 14
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA 0I6EP
UT WOS:000599383000001
PM 33327738
DA 2025-06-11
ER

PT J
AU Tahir, NT
   Alkhader, RAY
   ALfatlawi, WR
   Al-Auqbi, TFR
AF Tahir, Noor Thair
   Alkhader, Raghd A. Y.
   ALfatlawi, Wafaa Raji
   Al-Auqbi, Tawfeeq F. R.
TI Obesity is a Major Health Problem Threatening the Iraqis- review article
SO JOURNAL OF POPULATION THERAPEUTICS AND CLINICAL PHARMACOLOGY
LA English
DT Article
DE Obesity; Iraq; BMI; Age; gender; type 2 diabetes mellitus; COVID-19
ID LIFE-STYLE; PREVALENCE; DEPRESSION; OVERWEIGHT; VISFATIN; IMPACT
AB Obesity can be defined as an excessive or abnormal fat accumulation which may impair health. It is recognized as a top public health issue and it is ranked as the 5th foremost cause of death worldwide. The current review set out to summarize the studies which provide basic information about the obesity prevalence in Iraq (adults, children and adolescents); moreover, it set out to address the impact of obesity on multiple health conditions. It is now demonstrated that obesity (dependent upon the duration, distribution, and degree of the excess adipocytes/weight) may progressively exacerbate and/or cause a wide range of comorbidities. This review discusses the contributions of obesity toward the pathogenesis of type II diabetes, insulin resistance, metabolic syndrome, and COVID-19 in addition to other diseases.
C1 [Tahir, Noor Thair; Al-Auqbi, Tawfeeq F. R.] Mustansiriyah Univ, Natl Diabet Ctr, Baghdad, Iraq.
   [Alkhader, Raghd A. Y.] Mustansiriyah Univ, Coll Med, Dept Chem & Biochem, Baghdad, Iraq.
   [ALfatlawi, Wafaa Raji] Univ Technol Baghdad, Appl Sci Dept, Appl Chem Branch, Baghdad, Iraq.
C3 Mustansiriya University; Mustansiriya University; University of
   Technology- Iraq
RP Tahir, NT (corresponding author), Mustansiriyah Univ, Natl Diabet Ctr, Baghdad, Iraq.
EM dr.noorthair.ndc@uomustansiriyah.edu.iq
RI tahir, noor thair/JWD-5794-2024; ALKHADER, RAGHD/GXH-4432-2022
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NR 83
TC 0
Z9 0
U1 0
U2 0
PU RESEARCHTRENTZ ACAD PUBL EDUCATION SERVICES
PI Somerville
PA 240 Elm Street, 2nd & 3rd Floors, Somerville, MA, UNITED STATES
SN 2561-8741
J9 J POPUL THER CLIN PH
JI J. Popul. Ther. Clin. Pharmacol.
PY 2023
VL 30
IS 5
BP E532
EP E541
DI 10.47750/jptcp.2023.30.05.053
PG 10
WC Pharmacology & Pharmacy
WE Emerging Sources Citation Index (ESCI)
SC Pharmacology & Pharmacy
GA C9LW1
UT WOS:000965059800005
OA Bronze
DA 2025-06-11
ER

PT J
AU Rosenthal, T
   Nussinovitch, N
AF Rosenthal, Talma
   Nussinovitch, Naomi
TI Managing hypertension in the elderly in light of the changes during
   aging
SO BLOOD PRESSURE
LA English
DT Review
DE Aging; altered metabolism; polypharmacy
ID CONVERTING-ENZYME-INHIBITORS; ISOLATED SYSTOLIC HYPERTENSION;
   BLOOD-PRESSURE REDUCTION; ADVERSE DRUG-REACTIONS; ANTIHYPERTENSIVE
   DRUGS; MEDICATION USE; METABOLIC SYNDROME; VASCULAR DEMENTIA; ACTIVE
   TREATMENT; ACE-INHIBITORS
AB The natural rise in systolic blood pressure with age is often complicated by other co-morbidities. Pharmacokinetics and pharmacodynamics of antihypertensive drugs are altered during aging, resulting in decrease in absorption and function of the kidney and liver, as well as interactions and adverse reactions of antihypertensives with the often large number of medications taken by the elderly. The problem of compliance in the elderly that may be disrupted by depression, loss of memory, vascular dementia and other conditions that compromise cognition is also of concern. Despite the many issues facing healthcare providers in managing hypertension in the elderly, the benefits are extensively documented and warrant overcoming therapeutic inertia, especially in view of current access to well documented therapeutic options.
C1 [Rosenthal, Talma] Tel Aviv Univ, Dept Physiol & Pharmacol, Hypertens Res Unit, Sackler Sch Med, IL-69978 Tel Aviv, Israel.
   [Nussinovitch, Naomi] Chaim Sheba Med Ctr, Dept Med D, Ramat Gan, Israel.
C3 Tel Aviv University; Sackler Faculty of Medicine; Chaim Sheba Medical
   Center
RP Rosenthal, T (corresponding author), Tel Aviv Univ, Dept Physiol & Pharmacol, Hypertens Res Unit, Sackler Sch Med, IL-69978 Tel Aviv, Israel.
EM rtalma@post.tau.ac.il
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NR 84
TC 15
Z9 19
U1 1
U2 2
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0803-7051
EI 1651-1999
J9 BLOOD PRESSURE
JI Blood Pressure
PY 2008
VL 17
IS 4
BP 186
EP 194
DI 10.1080/08037050802305578
PG 9
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 361YL
UT WOS:000260163900002
PM 18663653
DA 2025-06-11
ER

PT J
AU Li, TP
   Fu, SY
   Huang, X
   Zhang, XS
   Cui, YM
   Zhang, ZY
   Ma, Y
   Zhang, X
   Yu, QH
   Yang, SN
   Li, SH
AF Li, Tuoping
   Fu, Siyu
   Huang, Xin
   Zhang, Xiushan
   Cui, Yanmin
   Zhang, Zuoyi
   Ma, Yue
   Zhang, Xuan
   Yu, Qianhui
   Yang, Shuning
   Li, Suhong
TI Biological properties and potential application of hawthorn and its
   major functional components: A review
SO JOURNAL OF FUNCTIONAL FOODS
LA English
DT Review
DE Hawthorn; Antioxidant; Glucose and lipid metabolism; Inflammation;
   Memory
ID HAW PECTIC OLIGOSACCHARIDE; CRATAEGUS-PINNATIFIDA; CHINESE HAWTHORN;
   OXIDATIVE STRESS; IN-VITRO; ANTIOXIDANT ACTIVITY; BIOACTIVE COMPOUNDS;
   METABOLIC SYNDROME; PHENOLIC-COMPOUNDS; DIABETES-MELLITUS
AB Hawthorn (Crataegus) widely distribute in the world, and is known as an excellent fruit resource commonly planted in China. It has been used for food and medicine for thousands of years in China. This paper surmised the up-to-date literatures on the functional properties of flavonoids, phenols, terpenoids and polysaccharides of hawthorn. Meanwhile, the application prospects of hawthorn in functional foods are also prospected. These will be helpful for the developments of functional foods or deep-processing technologies of hawthorn.
C1 [Li, Tuoping; Fu, Siyu; Huang, Xin; Zhang, Xiushan; Cui, Yanmin; Zhang, Zuoyi; Ma, Yue; Zhang, Xuan; Yu, Qianhui; Yang, Shuning; Li, Suhong] Shenyang Agr Univ, Coll Food Sci, Shenyang 110866, Peoples R China.
C3 Shenyang Agricultural University
RP Li, SH (corresponding author), Shenyang Agr Univ, Coll Food Sci, Shenyang 110866, Peoples R China.
EM leesuhong@syau.edu.cn
RI yu, QH/HOC-9806-2023
FU National Natural Science Foundation of China [32072225]; Applied Basic
   Research Program of Shenyang [F16-205-1-52]; scientific research
   foundation of Shenyang Agricultural University
FX This work was supported by the National Natural Science Foundation of
   China (32072225), the Applied Basic Research Program of Shenyang
   (F16-205-1-52) and the scientific research foundation of Shenyang
   Agricultural University.
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NR 77
TC 44
Z9 49
U1 30
U2 216
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1756-4646
EI 2214-9414
J9 J FUNCT FOODS
JI J. Funct. Food.
PD MAR
PY 2022
VL 90
AR 104988
DI 10.1016/j.jff.2022.104988
EA FEB 2022
PG 7
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA ZY3BQ
UT WOS:000772463100009
OA gold
DA 2025-06-11
ER

PT J
AU Wiecek, M
   Szymura, J
   Sproull, J
   Szygula, Z
AF Wiecek, Magdalena
   Szymura, Jadwiga
   Sproull, Justyna
   Szygula, Zbigniew
TI Whole-Body Cryotherapy Is an Effective Method of Reducing Abdominal
   Obesity in Menopausal Women with Metabolic Syndrome
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Article
DE whole-body cryotherapy; body composition; visceral obesity; menopausal
   women; metabolic syndrome; irisin; interleukin-6
ID OXIDATIVE STRESS; CRYOSTIMULATION; IRISIN; INFLAMMATION; PREVALENCE;
   OVERWEIGHT; EXPRESSION; LIPOLYSIS; MARKERS; FNDC5
AB Abdominal obesity predominates in menopausal women (MW) and contributes to the development of metabolic syndrome (MetS). It is associated with increased mortality related to cardiovascular disease, diabetes and fatty liver disease. The effects of whole-body cryotherapy (WBC) on body composition and the blood concentration of irisin, interleukin-6 (IL-6) and C-reactive proteins (CRP) in MW with MetS and in healthy women (HW), were assessed. The study included 19 women with MetS (61.53 +/- 3.99 y, BMI 30.09 +/- 4.98 kg/m(2)) and 18 HW (60.28 +/- 3.63 y, BMI 25.50 +/- 2.37 kg/m(2)) who were subjected to 20 WBC treatments at -130 degrees C for 3 min daily. In both groups, body mass (BM), BMI, abdominal circumference, triceps skinfold, total fat mass and percentage of leg fat significantly decreased after 20 WBC sessions. Additionally, the percentage of total, trunk and android fat in the MetS group were significantly decreased after 20 WBC applications. Waist circumference (WC) and waist-to-height ratio (WHtR) significantly decreased in both groups, and in the HW group, hip circumference and abdominal skinfold also significantly decreased after 10 WBC and 20 WBC treatments. In both groups, the concentration of plasma irisin significantly increased after 1 WBC and 10 WBC exposures, while the concentration of IL-6 significantly increased only in MetS group after 10 WBC and 20 WBC, and were significantly higher than in HW. CRP concentrations were significantly higher in the MetS group than in HW before 1 WBC, after 1 WBC and 10 WBC sessions, but not after 20. In the MetS group, there were significant negative correlations between the change in irisin level and the changes in WC and BM, and between the level of irisin and the change in percentage of total fat, and significant negative correlations between the change in IL-6 level and changes in WC, waist-to-hip ratio and WHtR. Whole-body cryotherapy, assuming the application of 20 treatments in the series, reduces abdominal obesity in menopausal women indirectly through the secretion of irisin and IL-6, and can be used as adjunctive therapy in the treatment of metabolic syndrome. Our conclusion is limited to menopausal women with low-moderate physical activity for whom its level as well as diet were not changed during the treatment.
C1 [Wiecek, Magdalena] Univ Phys Educ Krakow, Fac Phys Educ & Sport, Dept Physiol & Biochem, PL-31571 Krakow, Poland.
   [Szymura, Jadwiga] Univ Phys Educ Krakow, Fac Motor Rehabil, Dept Clin Rehabil, PL-31571 Krakow, Poland.
   [Sproull, Justyna] Univ Phys Educ Krakow, Fac Phys Educ & Sport, PL-31571 Krakow, Poland.
   [Szygula, Zbigniew] Univ Phys Educ Krakow, Fac Phys Educ & Sport, Inst Biomed Sci, PL-31571 Krakow, Poland.
RP Wiecek, M (corresponding author), Univ Phys Educ Krakow, Fac Phys Educ & Sport, Dept Physiol & Biochem, PL-31571 Krakow, Poland.
EM magdalena.wiecek@awf.krakow.pl; jadwiga.szymura@awf.krakow.pl;
   bednarekjustyna1@gmail.com; wfszygul@cyf-kr.edu.pl
RI Szymura, Jadwiga/V-6413-2018; Wiecek, Magdalena/P-8276-2018
OI Szymura, Jadwiga/0000-0003-4594-7954; Wiecek,
   Magdalena/0000-0002-5390-3049; Szygula, Zbigniew/0000-0002-6685-6579
FU National Science Centre, Poland [2014/2015/N/NZ7/03036]; University of
   Physical Education in Krakow, Poland
FX This research was funded by the National Science Centre, Poland, grant
   number 2014/2015/N/NZ7/03036, and partly by University of Physical
   Education in Krakow, Poland, grant number 2016/BS/INB/20. Open Access
   financed by University of Physical Education in Krakow, Poland.
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NR 59
TC 22
Z9 22
U1 0
U2 11
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD SEP
PY 2020
VL 9
IS 9
AR 2797
DI 10.3390/jcm9092797
PG 21
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA OE8LZ
UT WOS:000580776600001
PM 32872598
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Wu, Y
   Mills, D
   Bala, M
AF Wu, Ying
   Mills, Douglas
   Bala, Mohan
TI Psoriasis: Cardiovascular risk factors and other disease comorbidities
SO JOURNAL OF DRUGS IN DERMATOLOGY
LA English
DT Article
ID METABOLIC SYNDROME; INCREASED PREVALENCE; CLINICAL-FEATURES;
   HEALTH-CARE; EPIDEMIOLOGY; POPULATION; MORTALITY; THERAPY
AB The risk factors of cardiovascular disease and other disease comorbidities appear to be more common in patients with psoriasis compared with the general population. To support this concept, the association between psoriasis and cardiovascular disease and other comorbidities was analyzed using data collected from 40 730 patients in the National Health and Wellness Survey (NHWS) during May and June 2004. A case-control study was conducted with data from 1127 patients with psoriasis and a matched cohort of nonpsoriasis patients. Psoriasis patients were significantly more likely to have cardiovascular comorbidities, including hypertension, hypercholesterolemia, and diabetes, compared with nonpsoriasis patients. Other comorbidities significantly associated with psoriasis were arthritis, depression, sleep disorder/insomnia, chronic obstructive pulmonary disease, and gastroesophageal reflux disease. Responses to this large survey confirm that patients with psoriasis have a higher rate of cardiovascular risk factors and other comorbidities compared with patients without psoriasis.
C1 [Wu, Ying; Bala, Mohan] Centocor Inc, Malvern, PA 19355 USA.
C3 Johnson & Johnson; Johnson & Johnson USA; Janssen Biotech Inc
RP Wu, Y (corresponding author), Centocor Inc, Mailstop C-4-2,200 Great Valley Pkwy, Malvern, PA 19355 USA.
EM YWu3@cntus.jnj.com
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NR 28
TC 89
Z9 92
U1 0
U2 6
PU JOURNAL OF DRUGS IN DERMATOLOGY
PI NEW YORK
PA 377 PARK AVE SOUTH, 6TH FLOOR, NEW YORK, NY 10016 USA
SN 1545-9616
J9 J DRUGS DERMATOL
JI J. Drugs Dermatol.
PD APR
PY 2008
VL 7
IS 4
BP 373
EP 377
PG 5
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 294AH
UT WOS:000255376000009
PM 18459519
DA 2025-06-11
ER

PT J
AU Lindenberger, U
AF Lindenberger, Ulman
TI Human cognitive aging: Corriger la fortune?
SO SCIENCE
LA English
DT Review
ID ADULT AGE-DIFFERENCES; LIFE-SPAN; WORKING-MEMORY; HEALTHY-ADULTS;
   VASCULAR RISK; GENETIC CONTRIBUTIONS; EPISODIC MEMORY; BRAIN;
   INTELLIGENCE; PLASTICITY
AB Human cognitive aging differs between and is malleable within individuals. In the absence of a strong genetic program, it is open to a host of hazards, such as vascular conditions, metabolic syndrome, and chronic stress, but also open to protective and enhancing factors, such as experience-dependent cognitive plasticity. Longitudinal studies suggest that leading an intellectually challenging, physically active, and socially engaged life may mitigate losses and consolidate gains. Interventions help to identify contexts and mechanisms of successful cognitive aging and give science and society a hint about what would be possible if conditions were different.
C1 [Lindenberger, Ulman] Max Planck Inst Human Dev, Ctr Lifespan Psychol, D-14195 Berlin, Germany.
   [Lindenberger, Ulman] Max Planck Univ Coll London Ctr Computat Psychiat, London WC1B 5EH, England.
C3 Max Planck Society
RP Lindenberger, U (corresponding author), Max Planck Inst Human Dev, Ctr Lifespan Psychol, Lentzeallee 94, D-14195 Berlin, Germany.
EM seklindenberger@mpib-berlin.mpg.de
RI Lindenberger, Ulman/A-5846-2013
FU German Research Foundation (DFG); Federal Ministry of Education and
   Research
FX U.L. thanks R. Dolan, M. Lovden, N. Raz, and F. Schmiedek for providing
   valuable comments on an earlier version of this article, and the Max
   Planck Society for continued research support. Parts of the research
   described in this article were financed by a Gottfried Wilhelm Leibniz
   Award 2010 of the German Research Foundation (DFG) to U.L. and a grant
   from the Federal Ministry of Education and Research ("The Berlin Aging
   Study II").
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NR 120
TC 266
Z9 289
U1 2
U2 89
PU AMER ASSOC ADVANCEMENT SCIENCE
PI WASHINGTON
PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA
SN 0036-8075
EI 1095-9203
J9 SCIENCE
JI Science
PD OCT 31
PY 2014
VL 346
IS 6209
SI SI
BP 572
EP 578
DI 10.1126/science.1254403
PG 7
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Science & Technology - Other Topics
GA AR8BE
UT WOS:000343799700035
PM 25359964
OA Green Published
DA 2025-06-11
ER

PT J
AU Schröder, JB
   Petersen, SH
AF Schroder, Julie Bernstorf
   Petersen, Sven Hogh
TI What is the optimum protein level in infant formulas?
SO AGRO FOOD INDUSTRY HI-TECH
LA English
DT Article
ID ALPHA-LACTALBUMIN; ENERGY RATIO; TERM INFANTS; BIRTH; ADEQUATE; GROWTH;
   SAFE
AB Low protein is a hot topic in the development of infant formulas. The arguments for low protein formulas include optimal development, reduced stress on kidneys and the possible implication of excessive protein supply on later overweight and development of symptoms of the metabolic syndrome. Furthermore, the amino acid compositions of low protein infant formulas are more similar to human milk than that of high protein formulas, due to a different protein profile. Thus, reduction of the protein content has priority in producing better infant formula products, which are closer to human milk in composition and functionality, however safety should be closely monitored.
C1 [Schroder, Julie Bernstorf; Petersen, Sven Hogh] Arla Foods Ingredients Nutr, Team Pediat, DK-8260 Viby J, Denmark.
RP Schröder, JB (corresponding author), Arla Foods Ingredients Nutr, Team Pediat, Skanderborgsvej 234, DK-8260 Viby J, Denmark.
RI Petersen, Sven/V-6315-2019
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NR 15
TC 2
Z9 2
U1 0
U2 5
PU TEKNOSCIENZE PUBL
PI MILANO
PA VIALE BRIANZA 22, 20127 MILANO, ITALY
SN 1722-6996
EI 2035-4606
J9 AGRO FOOD IND HI TEC
JI Agro Food Ind. Hi-Tech
PD JUL-AUG
PY 2009
VL 20
IS 4
BP 22
EP 25
PG 4
WC Biotechnology & Applied Microbiology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Food Science & Technology
GA 505GP
UT WOS:000270680400007
DA 2025-06-11
ER

PT J
AU Chang, R
   Huang, ZY
   Zhao, SZ
   Zou, J
   Li, YK
   Tan, SJ
AF Chang, Rui
   Huang, Zeyi
   Zhao, Size
   Zou, Ju
   Li, Yukun
   Tan, Sijie
TI Emerging Roles of FTO in Neuropsychiatric Disorders
SO BIOMED RESEARCH INTERNATIONAL
LA English
DT Review
ID INDUCED WEIGHT-GAIN; BODY-MASS INDEX; OBESITY-ASSOCIATED GENE; METABOLIC
   SYNDROME; FAT MASS; RNA METHYLATION; SCHIZOPHRENIA; ASSOCIATION;
   DOPAMINE; RISK
AB FTO (fat mass and obesity associated) is a recently discovered gene related to obesity and expressed in various tissues of the human body, especially with high expression in the brain. Earlier studies have found that FTO is involved in several biological processes, including brain development and function. In particular, recent studies have found that FTO is a demethylase of N6-methyladenosine (m6A) and it can affect neurological function through the m6A modification of mRNA. At present, a number of studies have shown that FTO is associated with many neuropsychiatric disorders. This paper reviews the discovery, structure, function, and tissue expression of FTO followed by discussing the relationship between FTO and neuropsychiatric diseases. In addition, the potential roles of FTO gene in drug addiction, major depression (MDD), and schizophrenia (SCZ) through regulating m6A modification of dopamine related genes were also highlighted.
C1 [Chang, Rui; Huang, Zeyi; Zhao, Size; Zou, Ju; Li, Yukun; Tan, Sijie] Univ South China, Inst Clin Anat & Reprod Med, Sch Basic Med, Hengyang Med Sch, Hunan 421001, Hunan, Peoples R China.
C3 University of South China
RP Zou, J; Li, YK; Tan, SJ (corresponding author), Univ South China, Inst Clin Anat & Reprod Med, Sch Basic Med, Hengyang Med Sch, Hunan 421001, Hunan, Peoples R China.
EM 2896562623@qq.com; 1139481082@qq.com; 46664856@qq.com;
   2012002007@usc.edu.cn; 839571274@qq.com; sjtan@usc.edu.cn
RI chang, rui/KEI-1676-2024; Li, yukun/HZJ-2455-2023; Tan,
   Sijie/W-6260-2019
OI Tan, Sijie/0000-0002-8389-7372
FU National Science Foundation of China [NSFC 81301144]; Hunan Provincial
   Natural Science Foundation [2019JJ40250]; Research Project of Hunan
   Education Department [21C0312]; College Students Science and Technology
   Innovation Project of the University of South China and Hunan Province
   [210XCX486, 210XCX510, 200XCX322]
FX This work was supported by grants from the National Science Foundation
   of China (NSFC 81301144), Hunan Provincial Natural Science Foundation
   (2019JJ40250), and a Research Project of Hunan Education Department
   (21C0312). Size Zhao was supported by the College Students Science and
   Technology Innovation Project of the University of South China and Hunan
   Province (210XCX486, 210XCX510, and 200XCX322).
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NR 107
TC 19
Z9 20
U1 5
U2 23
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2314-6133
EI 2314-6141
J9 BIOMED RES INT
JI Biomed Res. Int.
PD APR 26
PY 2022
VL 2022
AR 2677312
DI 10.1155/2022/2677312
PG 9
WC Biotechnology & Applied Microbiology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Biotechnology & Applied Microbiology; Research & Experimental Medicine
GA 1G2RI
UT WOS:000795700000007
PM 35528183
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Kranjac, AW
   Nie, J
   Trevisan, M
   Freudenheim, JL
AF Kranjac, Ashley Wendell
   Nie, Jing
   Trevisan, Maurizio
   Freudenheim, Jo L.
TI Depression and body mass index, differences by education: Evidence from
   a population-based study of adult women in the US Buffalo-Niagara region
SO OBESITY RESEARCH & CLINICAL PRACTICE
LA English
DT Article
DE Depression; Obesity; Women's health; Education
ID METABOLIC SYNDROME; MENTAL-DISORDERS; OBESITY; HEALTH; ASSOCIATIONS;
   METAANALYSIS
AB The relationship between obesity and depression is well described. However, the evidence linking depression and body mass index (BMI) across the broad range of body size is less consistent. We examined the association between depressive symptoms and BMI in a sample of adult women in the Buffalo-Niagara region between 1997 and 2001. Using logistic regression, we investigated whether increased weight status beyond normal-weight was associated with a higher prevalence of depressive symptoms, and if educational attainment modified the association between obesity and depression. There was a trend for increased weight status to be associated with higher depressive symptoms (obese II/III, OR 1.57, 95% CI 1.03-2.41), whereas higher education was associated with lower odds of depressive symptoms, in an adjusted model including BMI (more than 12 but less than 16 years, OR 0.70, 95% CI 0.49-0.98; 16 or more years of education, OR 0.61, 95% CI 0.40-0.93). The association of being obese I with depressive symptoms was different for more educated (OR 2.15, 95% CI 1.27-3.62) compared to less educated women (OR 0.90, 95% CI 0.50-1.62); the sample was larger for the more educated women and reached statistical significance. There were no differences in the association for obese II/III women in strata of education. There was evidence of risk-difference heterogeneity (0.88, 95% CI 0.84-0.93). In this population-based sample of women in western New York state, increased weight was negligibly associated with depressive symptoms. The association of being obese I with depressive symptoms was different for more compared to less educated women. (C) 2016 Asia Oceania Association for the Study of Obesity. Published by Elsevier Ltd. All rights reserved.
C1 [Kranjac, Ashley Wendell] Rice Univ, Kinder Inst Urban Res, Dept Sociol, 6500 Main St 1020, Houston, TX 77005 USA.
   [Nie, Jing; Freudenheim, Jo L.] Univ Buffalo State Univ New York, Dept Epidemiol & Environm Hlth, Buffalo, NY USA.
   [Trevisan, Maurizio] CUNY City Coll, Sophie Davis Sch Biomed Educ, New York, NY USA.
C3 Rice University; State University of New York (SUNY) System; University
   at Buffalo, SUNY; City University of New York (CUNY) System; City
   College of New York (CUNY); Sophie Davis School of Biomedical Education
RP Kranjac, AW (corresponding author), Rice Univ, Kinder Inst Urban Res, Dept Sociol, 6500 Main St 1020, Houston, TX 77005 USA.
EM awkranjac@rice.edu
OI Freudenheim, Jo/0000-0002-9301-0499
FU National Institute on Alcohol Abuse and Alcoholism [P50-AA09802];
   Department of Defense [DAMD 179616202, DAMD 17030446]; National Cancer
   Institute [R01CA 092040]; Div Of Information & Intelligent Systems;
   Direct For Computer & Info Scie & Enginr [1514204] Funding Source:
   National Science Foundation
FX This work was supported in part by the National Institute on Alcohol
   Abuse and Alcoholism (P50-AA09802), the Department of Defense (DAMD
   179616202 and DAMD 17030446), and the National Cancer Institute (R01CA
   092040).
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NR 33
TC 11
Z9 12
U1 0
U2 4
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1871-403X
EI 1878-0318
J9 OBES RES CLIN PRACT
JI Obes. Res. Clin. Pract.
PD JAN-FEB
PY 2017
VL 11
IS 1
BP 63
EP 71
DI 10.1016/j.orcp.2016.03.002
PG 9
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA EO0PJ
UT WOS:000396400000008
PM 27025915
OA Bronze, Green Accepted
DA 2025-06-11
ER

PT J
AU Dols, A
   Rhebergen, D
   Beekman, A
   Kupka, R
   Sajatovic, M
   Stek, ML
AF Dols, Annemiek
   Rhebergen, Didi
   Beekman, Aartjan
   Kupka, Ralph
   Sajatovic, Martha
   Stek, Max L.
TI Psychiatric and Medical Comorbidities: Results from a Bipolar Elderly
   Cohort Study
SO AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
LA English
DT Article
DE Somatic; medical; psychiatric; comorbidity; bipolar; elderly
ID OLDER-ADULTS; DSM-IV; DISORDERS; PREVALENCE; ONSET; AGE
AB Objective: Bipolar disorder is associated with concurrent mental and physical disorders. Although well studied among younger adults, less is known about concurrent morbidity among older patients. This is important because comorbidity may increase with age and optimal treatment requires awareness of medical and psychiatric comorbidities. This study analyzed psychiatric and medical comorbidity in a Dutch bipolar elderly cohort. Methods: This cross-sectional descriptive study included demographic and clinical data on 101 bipolar patients aged 60 and over (mean age: 68.9 +/- 7.8 years); 53.4% were women. Psychiatric diagnoses were confirmed by semi-structured diagnostic interviews. Somatic history, including current somatic complaints, was obtained by interview. Medication and indicators of metabolic syndrome were obtained via record review. Results: Most patients received outpatient care. Bipolar I disorder was diagnosed in 56.4% of patients, and 75.6% had an onset of first affective symptoms before age 50. The prevalence rates of psychiatric comorbidities were low, except for lifetime alcohol dependence (24.8%) and abuse (13.9%). On average, there were 1.7 (SD: 1.6) medical comorbid conditions, predominantly hypertension (27.8%), arthrosis (29.1%), and allergies (25.6%). Polypharmacy was found in 31.7% of patients and metabolic syndrome in 28.7%. Conclusion: Psychiatric comorbidity (especially anxiety disorders) was relatively uncommon, except for substance use disorder. Geriatric bipolar patients had on average two comorbid medical conditions and relatively high medication use. Findings underline the need to assess for comorbid conditions in bipolar elders, thereby enabling tailored treatment to optimize the general condition of these patients.
C1 [Dols, Annemiek; Rhebergen, Didi; Stek, Max L.] GGZ inGeest VUmc, Dept Old Age Psychiat, NL-1081 JC Amsterdam, Netherlands.
   [Beekman, Aartjan; Kupka, Ralph] GGZ inGeest VUmc, Dept Psychiat, NL-1081 JC Amsterdam, Netherlands.
   [Sajatovic, Martha] Univ Hosp Cleveland, Case Med Ctr, Cleveland, OH 44106 USA.
C3 University Hospitals of Cleveland; University System of Ohio; Case
   Western Reserve University
RP Dols, A (corresponding author), GGZ inGeest VUmc, Old Age Psychiat, Amstelveenseweg 589, NL-1081 JC Amsterdam, Netherlands.
EM a.dols@ggzingeest.nl
RI Sajatovic, Martha/I-8001-2014; Kupka, Ralph/HDM-4184-2022; Beekman,
   Aartjan T./LUZ-6919-2024
OI Dols, Annemiek/0000-0003-1964-0318; Kupka, Ralph/0000-0002-1662-7436
FU Eli Lilly; Astra Zeneca; Jansen and Shire; AstraZeneca; Pfizer; Merck;
   Ortho-McNeil Janssen
FX Dr. Beekman has received unrestricted grants for research from Eli
   Lilly, Astra Zeneca, and Jansen and Shire and has received honoraria as
   a speaker from Eli Lilly and Lundbeck. Dr. Kupka has received
   unrestricted research grants from AstraZeneca; honoraria as a speaker
   from AstraZeneca, Lundbeck, and BristolMyersSquibb; and royalties from
   Wolters Kluwer Health. Dr. Sajatovic has received research grants from
   Pfizer, Merck, and Ortho-McNeil Janssen; served as a consultant for
   United BioSource Corporation (Bracket), Prophase, Pfizer, and Otsuka;
   and received royalties from Springer Press, Johns Hopkins University
   Press, and Oxford Press.
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NR 26
TC 51
Z9 53
U1 0
U2 20
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1064-7481
EI 1545-7214
J9 AM J GERIAT PSYCHIAT
JI Am. J. Geriatr. Psychiatr.
PD NOV
PY 2014
VL 22
IS 11
BP 1066
EP 1074
DI 10.1016/j.jagp.2013.12.176
PG 9
WC Geriatrics & Gerontology; Gerontology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Psychiatry
GA AR8YG
UT WOS:000343856600002
PM 24495405
DA 2025-06-11
ER

PT J
AU Szczuko, M
   Kaczkan, M
   Drozd, A
   Maciejewska, D
   Palma, J
   Owczarzak, A
   Marczuk, N
   Rutkowski, P
   Malgorzewicz, S
AF Szczuko, Malgorzata
   Kaczkan, Malgorzata
   Drozd, Arleta
   Maciejewska, Dominika
   Palma, Joanna
   Owczarzak, Anna
   Marczuk, Natalia
   Rutkowski, Przemyslaw
   Malgorzewicz, Sylwia
TI Comparison of Fatty Acid Profiles in a Group of Female Patients with
   Chronic Kidney Diseases (CKD) and Metabolic Syndrome (MetS)-Similar
   Trends of Changes, Different Pathophysiology
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE fatty acids; chronic kidney disease; metabolic syndrome; nutrition
ID ENDOPLASMIC-RETICULUM STRESS; POLYCYSTIC-OVARY-SYNDROME;
   INSULIN-RESISTANCE; ARACHIDONIC-ACID; NERVONIC ACID; CAPRYLIC-ACID;
   SERUM; RISK
AB Fatty acid (FA) profiles in the plasma of patients with metabolic syndrome and chronic kidney disease (CKD) seem to be identical despite their different etiology (dietary mistakes vs. cachexia). The aim of this study was to compare both profiles and to highlight the differences that could influence the improvement of the treatment of patients in both groups. The study involved 73 women, including 24 patients with chronic kidney disease treated with haemodialysis, 19 patients with metabolic syndrome (MetS), and 30 healthy women in the control group. A total of 35 fatty acids and derivatives were identified and quantified by gas chromatography. Intensified elongation processes from acid C10:0 to C16:0 were noted in both groups (more intense in MetS), as well as an increased synthesis of arachidonic acid (C20:4n6), which was more intense in CKD. Significant correlations of oleic acid (C18:1n9), gamma linoleic acid (C18:3n6), and docosatetraenoate acid (C22:4n6) with parameters of CKD patients were observed. In the MetS group, auxiliary metabolic pathways of oleic acid were activated, which simultaneously inhibited the synthesis of eicosapentanoic acid (EPA) and docosahexaenoic acid (DHA) from alpha lipoic acid (ALA). On the other hand, in the group of female patients with CKD, the synthesis of EPA and DHA was intensified. Activation of the synthesis of oleic acid (C18: 1n9 ct) and trans-vaccinic acid (C18:1) is a protective mechanism in kidney diseases and especially in MetS due to the increased concentration of saturated fatty acid (SFA) in plasma. The cause of the increased amount of all FAs in plasma in the CKD group, especially in the case of palmitic (C16:0) and derivatives stearic (C18:0) acids, may be the decomposition of adipose tissue and the progressing devastation of the organism, whereas, in the MetS group, dietary intake seems to be the main reason for the increase in SFA. Moreover, in MetS, auxiliary metabolic pathways are activated for oleic acid, which cause the simultaneous inhibition of EPA and DHA synthesis from ALA, whereas, in the CKD group, we observe an increased synthesis of EPA and DHA. The higher increase of nervonic acid (C24:1) in CKD suggests a higher degree of demyelination and loss of axons.
C1 [Szczuko, Malgorzata; Drozd, Arleta; Maciejewska, Dominika; Palma, Joanna] Pomeranian Med Univ, Dept Biochem & Human Nutr, PL-71460 Szczecin, Poland.
   [Kaczkan, Malgorzata; Owczarzak, Anna; Malgorzewicz, Sylwia] Med Univ Gdansk, Dept Clin Nutr, PL-80210 Gdansk, Poland.
   [Marczuk, Natalia] Pomeranian Med Univ, Dept Microbiol & Immunol, PL-71460 Szczecin, Poland.
   [Rutkowski, Przemyslaw] Med Univ Gdansk, Gen Nursery Dept, Diaverum Hemodialysis Unit, PL-80210 Gdansk, Poland.
C3 Pomeranian Medical University; Fahrenheit Universities; Medical
   University Gdansk; Pomeranian Medical University; Fahrenheit
   Universities; Medical University Gdansk; Diaverum
RP Szczuko, M (corresponding author), Pomeranian Med Univ, Dept Biochem & Human Nutr, PL-71460 Szczecin, Poland.
EM malgorzata.szczuko@pum.edu.pl; kaczkan@gumed.edu.pl;
   arleta.drozd@gmail.com; domi.maciejka@wp.pl; palma.01.01@gmail.com;
   anna.owczarzak@gumed.edu.pl; n.marczuk03@yahoo.pl;
   przemyslaw.rutkowski@gumed.edu.pl; sylwia.malgorzewicz@gumed.edu.pl
RI Maciejewska, Dominika/AAJ-7454-2020; Kaczkan, Małgorzata/V-3432-2018;
   Małgorzewicz, Sylwia/AAA-5945-2022; Drozd, Arleta/AGF-1128-2022; Palma,
   Joanna/AAE-7293-2020; Maciejewska-Markiewicz, Dominika/T-9081-2018;
   Szczuko, Malgorzata/A-9501-2015
OI Drozd, Arleta/0000-0002-5816-2040; Malgorzewicz,
   Sylwia/0000-0001-8773-9649; Palma, Joanna/0000-0003-0620-3776;
   Rutkowski, Przemyslaw/0000-0003-1177-3634; Maciejewska-Markiewicz,
   Dominika/0000-0002-2293-6489; Szczuko, Malgorzata/0000-0001-9808-0624
FU Department of Biochemistry and Human Nutrition, Pomeranian Medical
   University in Szczecin, Poland
FX The article is supported by statutory activity of the Department of
   Biochemistry and Human Nutrition, Pomeranian Medical University in
   Szczecin, Poland.
CR Alves FC, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0190410
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NR 30
TC 24
Z9 24
U1 1
U2 10
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD APR
PY 2019
VL 20
IS 7
AR 1719
DI 10.3390/ijms20071719
PG 13
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA HU4PM
UT WOS:000465258100062
PM 30959940
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Messier, L
   Elisha, B
   Schmitz, N
   Gariepy, G
   Malla, A
   Lesage, A
   Boyer, R
   Wang, JL
   Strychar, I
AF Messier, Lyne
   Elisha, Belinda
   Schmitz, Norbert
   Gariepy, Genevieve
   Malla, Ashok
   Lesage, Alain
   Boyer, Richard
   Wang, JianLi
   Strychar, Irene
TI Weight Cycling and Depressive Symptoms in Diabetes: A Community-Based
   Study of Adults with Type 2 Diabetes Mellitus in Quebec
SO CANADIAN JOURNAL OF DIABETES
LA English
DT Article
DE depression; type 2 diabetes; weight cycling
ID METABOLIC SYNDROME; BODY-WEIGHT; LIFE-STYLE; INDICATORS; PREVALENCE;
   RISK; MORTALITY; HISTORY; OBESITY
AB Objective: The problems of obesity and depression in type 2 diabetes mellitus are well documented, yet the role of weight cycling in relation to these 2 chronic conditions has not been examined. The study objective was to determine whether weight cycling predicts the development of depressive symptoms in the course of 1 year.
   Methods: A cohort study of 1100 adults with type 2 diabetes participating in the Diabetes Health and Well-Being Study (telephone survey using the random-digit-dialling method) had complete data at the 1-year follow up on depressive symptoms (Patient Health Questionnaire 9) and weight cycling frequency (going on a diet and losing >10 kg).
   Results: At baseline, 56.5% of subjects reported weight cycling on at least 1 occasion in their lifetime; it was found to be associated with baseline body mass index, depression, sex and age (p<0.05). Regression analyses indicated that severe weight cycling (>= 4 times) was not associated with the development of major depressive symptoms; however, it was associated with maintaining major depressive symptoms (p=0.038) but significance disappeared after adjusting for body mass index, physical activity, smoking and sociodemographic characteristics. Development and maintenance of major depressive symptoms were associated with physical inactivity (p<0.05); maintenance of major depressive symptoms was also associated with higher body mass index values (p<0.05).
   Conclusions: Weight cycling is a widespread phenomenon in diabetes. It was associated with depression, but severe cycling was not an independent predictor of the development and maintenance of major depressive symptoms. Clinicians should consider physical inactivity when evaluating and addressing depression in patients with type 2 diabetes. (C) 2014 Canadian Diabetes Association
C1 [Messier, Lyne; Elisha, Belinda; Strychar, Irene] Univ Montreal, Dept Nutr, Montreal, PQ H3C 3J7, Canada.
   [Elisha, Belinda; Strychar, Irene] Inst Recherches Clin Montreal, Montreal, PQ H3C 3J7, Canada.
   [Schmitz, Norbert; Malla, Ashok] McGill Univ, Dept Psychiat, Montreal, PQ, Canada.
   [Schmitz, Norbert; Gariepy, Genevieve; Malla, Ashok] Douglas Mental Hlth Univ Inst, Montreal, PQ, Canada.
   [Schmitz, Norbert; Strychar, Irene] Montreal Diabet Res Ctr, Montreal, PQ, Canada.
   [Gariepy, Genevieve] McGill Univ, Dept Epidemiol, Montreal, PQ, Canada.
   [Lesage, Alain] Univ Montreal, Dept Psychiat, Montreal, PQ H3C 3J7, Canada.
   [Lesage, Alain; Boyer, Richard] Inst Univ Sante Mentale Montreal, Ctr Rech Fernand Seguin, Montreal, PQ, Canada.
   [Wang, JianLi] Univ Calgary, Fac Med, Dept Community Hlth Sci, Dept Psychiat, Calgary, AB, Canada.
   [Strychar, Irene] Univ Montreal, Ctr Hosp, Ctr Rech, Montreal, PQ, Canada.
C3 Universite de Montreal; Universite de Montreal; McGill University;
   Universite de Montreal; McGill University; Universite de Montreal;
   Universite de Montreal; University of Calgary; Universite de Montreal
RP Strychar, I (corresponding author), Univ Montreal, Fac Med, Dept Nutr, 2405 Chemin Cote Ste Catherine,CP 6128, Montreal, PQ H3C 3J7, Canada.
EM irene.strychar@umontreal.ca
RI Schmitz, Norbert/AAH-3624-2020; Schmitz, Norbert/A-5177-2010
OI ELISHA, Belinda/0009-0006-0085-6900; Schmitz,
   Norbert/0000-0001-7777-6323
FU Canadian Institutes of Health Research [MOP-84574]; Diabete Quebec;
   Department of Nutrition and the Faculty of Graduate and Postdoctoral
   Studies, University of Montreal
FX This study was supported by an operating grant from the Canadian
   Institutes of Health Research (MOP-84574). L. Messier received a
   doctoral student scholarship from Diabete Quebec, summer 2010, and from
   the Department of Nutrition and the Faculty of Graduate and Postdoctoral
   Studies, University of Montreal.
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NR 31
TC 6
Z9 8
U1 0
U2 10
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1499-2671
J9 CAN J DIABETES
JI Can. J. Diabetes
PD DEC
PY 2014
VL 38
IS 6
BP 456
EP 460
DI 10.1016/j.jcjd.2014.01.005
PG 5
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA AU1LO
UT WOS:000345382400013
PM 25034243
DA 2025-06-11
ER

PT J
AU Lloyd, GL
   Makedon, AM
   Marks, JM
   Wiesen, B
   Carmichael, H
AF Lloyd, Granville L.
   Makedon, Alan M.
   Marks, Jeffrey M.
   Wiesen, Brett
   Carmichael, Heather
TI The relationship of depression, alcohol and marijuana with treatment for
   LUTS/BPH
SO CANADIAN JOURNAL OF UROLOGY
LA English
DT Article
DE BPH; voiding; LUTS; prostate; marijuana
ID URINARY-TRACT SYMPTOMS; BENIGN PROSTATIC HYPERPLASIA; BLADDER; MEN;
   CANNABINOIDS; ASSOCIATION; DYSFUNCTION; SEVERITY; EFFICACY
AB Introduction: Despite widespread usage, research on the relationship of marijuana use to disease is sorely lacking. We sought to test the relationship of LUTS/BPH treatment and endocannabinoid agonist usage, as well as alcohol usage and depression, with treatment for LUTS/BPH in our health system.
   Materials and methods: We queried our hospital system database of nearly three million patients in a marijuana-legalized region for data from the electronic medical record between January 2011 and October 2018. Men over the age of 45 on medical therapy for LUTS (selective alpha blockade and/or finasteride) were included. Exclusions were diagnosis of bladder or prostate malignancy and men with only one visit. Alcohol and marijuana (MJ) use were found from diagnosis code and/or social history text. Medical diagnoses were based on ICD-9/10 codes. Multiple logistic regression was used to control for confounders. We considered all men over the age of 45 who had any of these features: depression, obesity or metabolic syndrome (MetS), hypertension (HTN), erectile dysfunction (ED), hypogonadism, diabetes (DM) and calculated the odds ratio of also receiving medical therapy for LUTS. Univariable and multivariable analyses were employed, multiple logistic regression was used to control for confounders.
   Results: A total of 173,469 patients were identified meeting criteria with 20,548 (11.9%) on medical treatment for LUTS. After adjusting for confounding variables, MJ and depression remained associated with an increased risk of LUTS medication, within the context of verifying previously established relationships of ED, Obesity/MetS, DM, HTN and hypogonadism.
   Conclusions: Men with depression and MJ usage were more likely to be treated for LUTS/BPH in our system. Better understanding of the causality of this relationship and potential interaction of LUTS/BPH with the endocannabinoid system is desirable.
C1 [Lloyd, Granville L.; Makedon, Alan M.; Wiesen, Brett; Carmichael, Heather] Univ Colorado, Dept Surg, Div Urol, Anschutz Sch Med, Aurora, CO USA.
   [Marks, Jeffrey M.] Kansas City Urol Care, Overland Pk, KS USA.
C3 University of Colorado System; University of Colorado Anschutz Medical
   Campus
RP Lloyd, GL (corresponding author), Univ Colorado, Anschutz Sch Med, Dept Surg Urol, Rocky Mt Reg Vet Hosp, Aurora, CO 80045 USA.
RI Lloyd, Granville/AAD-9749-2021
FU Health Data Compass Data Warehouse project
FX Supported by the Health Data Compass Data Warehouse project
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NR 30
TC 1
Z9 1
U1 0
U2 1
PU CANADIAN J UROLOGY
PI ST LAURENT
PA 2330 WARD ST, STE 604, ST LAURENT, QUEBEC H4M 2V6, CANADA
SN 1195-9479
J9 CAN J UROL
JI Can. J. Urol.
PD AUG
PY 2022
VL 29
IS 4
BP 11249
EP 11254
PG 6
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 3Y4BM
UT WOS:000843671300009
PM 35969729
DA 2025-06-11
ER

PT J
AU Gaffo, AL
   Saag, KG
AF Gaffo, Angelo L.
   Saag, Kenneth G.
TI Drug Treatment of Hyperuricemia to Prevent Cardiovascular Outcomes Are
   We There Yet?
SO AMERICAN JOURNAL OF CARDIOVASCULAR DRUGS
LA English
DT Article
ID SERUM URIC-ACID; NUTRITION EXAMINATION SURVEY; 3RD NATIONAL-HEALTH;
   BLOOD-PRESSURE; GLOMERULAR HYPERTENSION; HEART-FAILURE; INCIDENT
   HYPERTENSION; METABOLIC SYNDROME; DECISION-ANALYSIS; OXIDATIVE STRESS
AB Data supporting an association between high levels of serum urate and cardiovascular disease have continued to emerge. Basic science data, small clinical trials, and epidemiologic studies have provided support for the idea of a true causal effect. In this paper, we present evidence about the association between hyperuricemia and selected cardiovascular diseases. Although data generated so far compellingly support pharmacologic urate-lowering therapy in selected cases with high cardiovascular risk, further evidence is necessary before widely advocating this approach to prevent cardiovascular outcomes putatively associated with hyperuricemia.
C1 [Gaffo, Angelo L.] Birmingham VA Med Ctr, Birmingham, AL USA.
   [Gaffo, Angelo L.; Saag, Kenneth G.] Univ Alabama Birmingham, Div Clin Immunol & Rheumatol, Birmingham, AL 35294 USA.
C3 US Department of Veterans Affairs; Veterans Health Administration (VHA);
   Veterans Affairs Medical Center - Birmingham; University of Alabama
   System; University of Alabama Birmingham
RP Saag, KG (corresponding author), FOT 820,1530 3rd Ave S, Birmingham, AL 35294 USA.
EM ksaag@uab.edu
RI Gaffo, Angelo/ABD-1653-2021
OI Gaffo, Angelo/0000-0001-7365-7212
FU Takeda; Savient; Merck
FX Dr Saag is a consultant to Takeda, Savient, and Merck. He has received
   research grants from Takeda, Savient, and Merck. Dr Gaffo has no
   conflicts of interest to declare.
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NR 58
TC 8
Z9 9
U1 0
U2 3
PU ADIS INT LTD
PI NORTHCOTE
PA 5 THE WAREHOUSE WAY, NORTHCOTE 0627, AUCKLAND, NEW ZEALAND
SN 1175-3277
EI 1179-187X
J9 AM J CARDIOVASC DRUG
JI Am. J. Cardiovasc. Drugs
PY 2012
VL 12
IS 1
BP 1
EP 6
PG 6
WC Cardiac & Cardiovascular Systems; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Pharmacology & Pharmacy
GA 905NE
UT WOS:000301278100001
PM 22204636
DA 2025-06-11
ER

PT J
AU Corona, G
   Mannucci, E
   Ricca, V
   Lotti, F
   Boddi, V
   Bandini, E
   Balercia, G
   Forti, G
   Maggi, M
AF Corona, G.
   Mannucci, E.
   Ricca, V.
   Lotti, F.
   Boddi, V.
   Bandini, E.
   Balercia, G.
   Forti, G.
   Maggi, M.
TI The age-related decline of testosterone is associated with different
   specific symptoms and signs in patients with sexual dysfunction
SO INTERNATIONAL JOURNAL OF ANDROLOGY
LA English
DT Article
DE ageing; erectile dysfunction; sexual dysfunction; structured interview
   on erectile dysfunction; testosterone
ID ERECTILE DYSFUNCTION; OLDER MEN; REPLACEMENT THERAPY; SERUM
   TESTOSTERONE; METABOLIC SYNDROME; ESTRADIOL; DISEASE; CHOLESTEROL;
   ANDROGENS; MORTALITY
AB P>In males, testosterone (T) levels decline with ageing. Several symptoms characteristic of the ageing process are similar to those related to hypogonadism. The aim of the present study was to evaluate the specific association among hypogonadism-related symptoms and signs and the ageing process. A consecutive series of 1647 (mean age 52.4 +/- 13.1 years) male patients with sexual dysfunction were investigated. Several hormonal and biochemical, instrumental and psychological parameters were studied. The parameters significantly associated with total levels in the entire cohort, after adjustment for confounders, were studied as a function of age and T quartiles. In all age quartiles, low T was associated with higher waist circumference and triglyceride levels and with an increased prevalence of metabolic syndrome. The prevalence of hypoactive sexual desire decreased as a function of T only in the youngest (17- to 42-year old) age quartile as well as the reported reduction in nocturnal erections. In the oldest age quartile, we found an inverse relationship between T levels and the prevalence of severe erectile dysfunction and a positive relationship with intercourse frequency. Accordingly, in the oldest age quartile, subjects with higher T levels showed better penile flow at penile colour doppler ultrasound as well as a better lipid profile. Finally, an inverse association between somatized anxiety and T levels was observed only in the oldest age quartile. In conclusion, our study shows for the first time that in subjects with sexual dysfunction, some hypogonadism-related symptoms can be age-specific. In particular, low T is associated with sexual dysfunction more often in the oldest subjects.
C1 [Corona, G.; Lotti, F.; Boddi, V.; Bandini, E.; Forti, G.; Maggi, M.] Univ Florence, Dept Clin Physiopathol, Androl Unit, I-50139 Florence, Italy.
   [Corona, G.] Maggiore Bellaria Hosp, Endocrinol Unit, Bologna, Italy.
   [Mannucci, E.] Univ Florence, Dept Crit Care, Diabet Sect, Geriatr Unit, I-50139 Florence, Italy.
   [Ricca, V.] Univ Florence, Dept Neurol & Psychiat Sci, Psychiat Unit, I-50139 Florence, Italy.
   [Balercia, G.] Polytechn Univ Marche, Endocrinol Unit, Ancona, Italy.
C3 University of Florence; AUSL di Bologna; University of Florence;
   University of Florence; Marche Polytechnic University
RP Maggi, M (corresponding author), Univ Florence, Dept Clin Physiopathol, Androl Unit, Viale Pieraccini 6, I-50139 Florence, Italy.
EM m.maggi@dfc.unifi.it
RI Lotti, Francesco/AAC-3186-2019; Maggi, Mario/AAB-8284-2019; ricca,
   valdo/K-8382-2012; Mannucci, Edoardo/K-6749-2016; LOTTI,
   Francesco/K-1801-2018
OI ricca, valdo/0000-0002-9291-2124; Mannucci, Edoardo/0000-0001-9759-9408;
   MAGGI, Mario/0000-0003-3267-4221; LOTTI, Francesco/0000-0001-8343-1807
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NR 37
TC 92
Z9 95
U1 0
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0105-6263
EI 1365-2605
J9 INT J ANDROL
JI Int. J. Androl.
PD DEC
PY 2009
VL 32
IS 6
BP 720
EP 728
DI 10.1111/j.1365-2605.2009.00952.x
PG 9
WC Andrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 516DI
UT WOS:000271521500016
PM 19226406
OA Bronze
DA 2025-06-11
ER

PT J
AU Simenson, AJ
   Corey, S
   Markovic, N
   Kinsky, S
AF Simenson, Ashley J.
   Corey, Stephanie
   Markovic, Nina
   Kinsky, Suzanne
TI Disparities in Chronic Health Outcomes and Health Behaviors Between
   Lesbian and Heterosexual Adult Women in Pittsburgh: A Longitudinal Study
SO JOURNAL OF WOMENS HEALTH
LA English
DT Article
DE women's health; sexual orientation; heterosexual women; lesbian women;
   health behavior
ID C-REACTIVE PROTEIN; MASS INDEX TRAJECTORIES; SEXUAL ORIENTATION; NURSES
   HEALTH; METABOLIC SYNDROME; EATING-DISORDERS; DEPRESSION; POPULATION;
   PREVALENCE; SMOKING
AB Background:Compared to heterosexual women, lesbian women experience higher rates of many chronic diseases, including depression, obesity, hypertension, and diabetes. Lesbian women report higher rates of risky health behaviors such as hazardous drinking and cigarette smoking. However, little longitudinal research has been done to examine changes in disparities between lesbian and heterosexual adult women. Methods:A total of 1,084 women were initially recruited from Pittsburgh, PA to participate in the Epidemiologic Study of HEalth Risk in Women (ESTHER) study and completed a baseline survey between 2003 and 2006. In 2015 or 2016,N = 483 women, 270 of whom were lesbian, completed a follow-up survey. Participants completed a questionnaire at both baseline and follow-up and completed a clinic visit for the baseline study to provide biometric data. Results:At baseline, lesbian participants reported higher rates of obesity (p = 0.03), depression (p = 0.02), and smoking (p = 0.04). Lesbian participants had elevated measured C-reactive protein levels (p = 0.05). By the time of the follow-up survey 10 years later, lesbian women continued to have higher rates of smoking (p = 0.04), but the disparity in depression (p = 0.53) and obesity (p = 0.24) rates had resolved. We found no differences in any other outcomes of interest. Conclusions:To our knowledge, this is the first study to report a resolution in obesity or depression disparities between lesbian and heterosexual women. Future research is necessary to determine if other disparities, such as respiratory conditions, appear over time and how lesbian women's health may continue to improve relative to heterosexual women and stem this public health inequity.
C1 [Simenson, Ashley J.; Corey, Stephanie; Markovic, Nina] Univ Pittsburgh, Grad Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA 15261 USA.
   [Markovic, Nina] Univ Pittsburgh, Sch Dent Med, Dept Dent Publ Hlth, Pittsburgh, PA 15261 USA.
   [Kinsky, Suzanne] Univ Pittsburgh, Grad Sch Publ Hlth, Dept Behav & Community Hlth Sci, Pittsburgh, PA 15261 USA.
   [Kinsky, Suzanne] Univ Pittsburgh, Ctr High Value Hlth Care, Med Ctr UPMC, Pittsburgh, PA 15261 USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE); University
   of Pittsburgh; Pennsylvania Commonwealth System of Higher Education
   (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of
   Higher Education (PCSHE); University of Pittsburgh; Pennsylvania
   Commonwealth System of Higher Education (PCSHE); University of
   Pittsburgh
RP Simenson, AJ (corresponding author), Univ Pittsburgh, Grad Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA 15261 USA.
EM simenson@pitt.edu
RI Corey, Stephanie/AHB-1439-2022
OI Kinsky, Suzanne/0000-0001-6957-2566
FU National Institutes of Health [NIH-NHLBI RO1HL067052]; Lesbian Health
   Fund of the Gay and Lesbian Medical Association
FX Funding provided by the National Institutes of Health (NIH-NHLBI
   RO1HL067052) and a research grant from the Lesbian Health Fund of the
   Gay and Lesbian Medical Association.
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NR 65
TC 7
Z9 8
U1 0
U2 9
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-9996
EI 1931-843X
J9 J WOMENS HEALTH
JI J. Womens Health
PD AUG 1
PY 2020
VL 29
IS 8
BP 1059
EP 1067
DI 10.1089/jwh.2019.8052
EA JUL 2020
PG 9
WC Public, Environmental & Occupational Health; Medicine, General &
   Internal; Obstetrics & Gynecology; Women's Studies
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; General & Internal
   Medicine; Obstetrics & Gynecology; Women's Studies
GA ND6ZD
UT WOS:000547976600001
PM 32639182
OA Green Published
DA 2025-06-11
ER

PT J
AU Liu, M
   Yun, P
   Hu, Y
   Yang, J
   Khadka, RB
   Peng, XC
AF Liu, Miao
   Yun, Peng
   Hu, Ying
   Yang, Jiao
   Khadka, Rim Bahadur
   Peng, Xiaochun
TI Effects of Grape Seed Proanthocyanidin Extract on Obesity
SO OBESITY FACTS
LA English
DT Review
DE Grape seed proanthocyanidin extract; Obesity; Mechanism
ID DIET-INDUCED OBESITY; HIGH-FAT DIET; BROWN ADIPOSE-TISSUE;
   ENERGY-BALANCE; INSULIN-RESISTANCE; OXIDATIVE STRESS; GENE-EXPRESSION;
   MIR-122 LEVELS; MESSENGER-RNA; LIVER MIR-33A
AB Obesity is a chronic metabolic disease resulting from excessive fat accumulation and/or abnormal distribution caused by multiple factors. As a major component of metabolic syndrome, obesity is closely related to many diseases such as type 2 diabetes mellitus, hyperlipidemia, hypertension, coronary heart disease, stroke and cancer. Hence, the problem of obesity cannot be ignored, and recent studies have shown that grape seed proanthocyanidin extract (GSPE) has an antiobesity effect. This paper systematically reviews the research progress and potential mechanism of GSPE emphasizing on obesity prevention and treatment.
C1 [Liu, Miao; Hu, Ying; Yang, Jiao; Peng, Xiaochun] Yangtze Univ, Med Sch, Jingzhou, Peoples R China.
   [Yun, Peng] Sun Yat Sen Univ, Affiliated Hosp 7, Dept Endocrinol, Shenzhen, Peoples R China.
   [Khadka, Rim Bahadur] Yangtze Univ, Jingzhou, Peoples R China.
C3 Yangtze University; Sun Yat Sen University; Yangtze University
RP Peng, XC (corresponding author), Yangtze Univ, Med Sch, Nanhuan Rd 1, Jingzhou City 434023, Hubei Province, Peoples R China.
EM pxcwd789@sina.com
RI peng, xiaochun/HJI-4832-2023
OI peng, xiaochun/0000-0001-9443-0439; yun, peng/0000-0003-3887-729X
FU Nature Science Foundation of Hubei province [2017CFB786]; medical school
   Youth Fund of Yangtze University [YXYQ201411]; Jingzhou Science and
   Technology Bureau Project [2017-93]
FX This work was supported by the Nature Science Foundation of Hubei
   province (2017CFB786), a medical school Youth Fund of Yangtze University
   (YXYQ201411) and a Jingzhou Science and Technology Bureau Project
   (2017-93).
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NR 103
TC 49
Z9 50
U1 8
U2 81
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1662-4025
EI 1662-4033
J9 OBESITY FACTS
JI Obes. Facts
PD MAY
PY 2020
VL 13
IS 2
BP 279
EP 291
DI 10.1159/000502235
PG 13
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA LO8HW
UT WOS:000533867800016
PM 32114568
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Govindarajan, G
   Whaley-Connell, A
   Mugo, M
   Stump, C
   Sowers, JR
AF Govindarajan, G
   Whaley-Connell, A
   Mugo, M
   Stump, C
   Sowers, JR
TI The cardiometabolic syndrome as a cardiovascular risk factor
SO AMERICAN JOURNAL OF THE MEDICAL SCIENCES
LA English
DT Article
DE cardiometabolic syndrome; obesity; hypertension; microalbuminuria;
   endothelial dysfunction
ID CORONARY-HEART-DISEASE; VASCULAR SMOOTH-MUSCLE; LOWERS BLOOD-PRESSURE;
   SAN-ANTONIO HEART; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   ANGIOTENSIN-II; ASSOCIATION CONFERENCE; HYPERINSULINEMIA; HYPERTENSION
AB The cardiometabolic syndrome (CMS) is associated with cardiovascular disease (CVD) and includes a constellation of risk factors such as central obesity, hypertension, insulin resistance, dyslipidemia, microalbuminuria, and hypercoagulability. Collectively, these risk factors increase CVD endpoints such as stroke, congestive heart failure, chronic kidney disease (CKD), and overall mortality. The CMS is associated with endothelial dysfunction, inflammation, abnormal thrombolysis, and increased oxidative stress that accentuate progression of CVD. We will review how the varying components of the CMS relate to an increased CVD and renal disease risk.
C1 Univ Missouri, Sch Med, Dept Internal Med & Physiol, Columbia, MO 65212 USA.
   Univ Missouri, Dept Pharmacol, Columbia, MO 65212 USA.
   Harry S Truman VA Med Ctr, Columbia, MO 65212 USA.
C3 University of Missouri System; University of Missouri Columbia;
   University of Missouri System; University of Missouri Columbia; US
   Department of Veterans Affairs; Veterans Health Administration (VHA);
   Harry S. Truman Memorial Veterans' Hospital
RP Univ Missouri, Hlth Sci Ctr, Dept Internal Med, Div Nephrol, 1 Hosp Dr,MA436,DC 043-0, Columbia, MO 65212 USA.
EM whaleyconnella@health.missouri.edu
OI Whaley-Connell, Adam/0000-0001-8955-5560
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NR 54
TC 60
Z9 71
U1 0
U2 6
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0002-9629
EI 1538-2990
J9 AM J MED SCI
JI Am. J. Med. Sci.
PD DEC
PY 2005
VL 330
IS 6
BP 311
EP 318
DI 10.1097/00000441-200512000-00009
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 995VJ
UT WOS:000234132200009
PM 16355016
DA 2025-06-11
ER

PT J
AU Cotrim, C
   Palinkas, ED
   Cotrim, N
AF Cotrim, Carlos
   Palinkas, Eszter Dalma
   Cotrim, Nuno
TI The Importance of Left Ventricular Outflow Tract and Mid-Ventricular
   Gradients in Stress Echocardiography: A Narrative Review
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Review
DE intraventricular gradients; exercise echocardiography; angina; athletes;
   hypertrophic cardiomyopathy; tiredness with normal systolic function;
   syncope or dizziness related to exercise
ID INTRAVENTRICULAR PRESSURE-GRADIENTS; HYPERTROPHIC CARDIOMYOPATHY;
   EXERCISE ECHOCARDIOGRAPHY; AMERICAN SOCIETY; OBSTRUCTION; CARDIOLOGY;
   RECOMMENDATIONS; GUIDELINES; VELOCITIES; MECHANISM
AB This review aims to serve as a guide for clinical practice and to appraise the current knowledge on exercise stress echocardiography in the evaluation of intraventricular obstruction in HCM, in patients with cardiac syndrome X, in athletes with symptoms related to exercise, and in patients with normal left ventricular systolic function and exercise-related unexplained tiredness. The appearance of intraventricular obstruction while exercising is considered rare, and it usually occurs in patients with hypertrophy of the left ventricle. The occurrence of intraventricular obstruction when exercising has been evidenced in patients with hypertrophic cardiomyopathy, athletes, patients with cardiac syndrome X, patients with syncope or dizziness related to exercise, and patients with dyspnea and preserved ejection fraction. The clinical significance of this observation and the exercise modality that is most likely to trigger intraventricular obstruction remains unknown. Supine exercise and lying supine after exercise are less technically demanding, but they are also less physiologically demanding than upright exercise. Importantly, in everyday life, human beings generally do not become supine after exercise, as takes place in post-exercise treadmill stress echocardiograms in most echocardiography labs. The presence of induced intraventricular obstruction might be considered when patients have exercise-related symptoms that are not understood, and to assess prognosis in hypertrophic cardiomyopathy.
C1 [Cotrim, Carlos] Heart Ctr Hosp Cruz Vermelha, P-1500048 Lisbon, Portugal.
   [Cotrim, Carlos] UCARDIO, Cardiovasc Unit, P-2350325 Riachos, Portugal.
   [Cotrim, Carlos] Hosp Particular Algarve, P-8005226 Gambelas, Faro, Portugal.
   [Palinkas, Eszter Dalma] Univ Szeged, Doctoral Sch Clin Med, H-6720 Szeged, Hungary.
   [Cotrim, Nuno] Santarem Hosp, P-2005177 Santarem, Portugal.
C3 Szeged University
RP Cotrim, C (corresponding author), Heart Ctr Hosp Cruz Vermelha, P-1500048 Lisbon, Portugal.; Cotrim, C (corresponding author), UCARDIO, Cardiovasc Unit, P-2350325 Riachos, Portugal.; Cotrim, C (corresponding author), Hosp Particular Algarve, P-8005226 Gambelas, Faro, Portugal.
EM carlosadcotrim@gmail.com; palinkaseszti@hotmail.com;
   nuno_cotrim1@hotmail.com
RI Cotrim, Carlos/AAI-1691-2021; Pálinkás, Eszter/HGF-2606-2022
OI Cotrim, Carlos/0000-0002-4802-0831; Palinkas, Eszter
   Dalma/0000-0003-0713-3909
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NR 45
TC 7
Z9 7
U1 1
U2 1
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD AUG
PY 2023
VL 12
IS 16
AR 5292
DI 10.3390/jcm12165292
PG 13
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA Q4NQ8
UT WOS:001057308100001
PM 37629333
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Baptista-Gonzalez, H
   Chavez-Tapia, NC
   Zamora-Valdés, D
   Uribe, M
   Mendez-Sanchez, N
AF Baptista-Gonzalez, Hector
   Chavez-Tapia, Norberto C.
   Zamora-Valdes, Daniel
   Uribe, Misael
   Mendez-Sanchez, Nahum
TI Importance of iron and iron metabolism in nonalcoholic fatty liver
   disease
SO MINI-REVIEWS IN MEDICINAL CHEMISTRY
LA English
DT Review
DE iron; iron overload; insulin resistance; metabolic syndrome;
   nonalcoholic fatty liver disease
ID MITOCHONDRIAL PERMEABILITY TRANSITION; OXIDATIVE STRESS;
   GENE-EXPRESSION; HEPATIC IRON; INSULIN-RESISTANCE; SERUM FERRITIN;
   IN-VIVO; OVERLOAD; HEMOCHROMATOSIS; ACTIVATION
AB Iron homeostasis disturbances are associated with liver disease. Non-alcoholic steatohepatitis is part of the spectrum of non-alcoholic fatty liver disease, which can progress to hepatic cirrhosis and end-stage liver disease. Increasing information supports that multiple factors underlie the development and progression of nonalcoholic steatohepatitis. However, the relation between non-alcoholic steatohepatitis and iron metabolism/overload is still controversial. We review the recent literature, both basic and clinical, regarding iron homeostasis as it pertains to the pathogenesis of nonalcoholic fatty liver disease.
C1 [Uribe, Misael; Mendez-Sanchez, Nahum] Med Clin & Fdn, Dept Biomed Res, Gastroenterol & Liver Unit, Mexico City, DF, Mexico.
   [Baptista-Gonzalez, Hector] Inst Nacl Perinatol, Subdirecc Invest Clin, Mexico City, DF, Mexico.
   [Chavez-Tapia, Norberto C.; Uribe, Misael] Inst Nacl Ciencias Med & Nutr Zalvador Zubiran, Dept Gastroenterol, Mexico City, DF, Mexico.
   [Zamora-Valdes, Daniel] Univ Veracruzana, Fac Med, Xalapa 91000, Veracruz, Mexico.
C3 Universidad Nacional Autonoma de Mexico; Instituto Nacional de Ciencias
   Medicas y Nutricion Salvador Zubiran - Mexico; Universidad Veracruzana
RP Mendez-Sanchez, N (corresponding author), Med Clin & Fdn, Dept Biomed Res, Gastroenterol & Liver Unit, Puente Piedra 150, Mexico City, DF, Mexico.
EM nmendez@medicasur.org.mx
RI ; Zamora-Valdes, Daniel/N-1399-2017
OI Uribe, Misael/0000-0002-6514-7869; Zamora-Valdes,
   Daniel/0000-0001-6821-1478; Chavez-Tapia, Norberto/0000-0002-7451-3306;
   Baptista, Hector/0000-0003-0340-0942
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TC 6
Z9 7
U1 1
U2 17
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1389-5575
EI 1875-5607
J9 MINI-REV MED CHEM
JI Mini-Rev. Med. Chem.
PD FEB
PY 2008
VL 8
IS 2
BP 171
EP 174
PG 4
WC Chemistry, Medicinal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 276FD
UT WOS:000254125800009
PM 18289100
DA 2025-06-11
ER

PT J
AU Qi, GY
   Wu, WQ
   Mi, YS
   Shi, RJ
   Sun, KY
   Li, RN
   Liu, X
   Liu, XB
AF Qi, Guoyuan
   Wu, Wanqiang
   Mi, Yashi
   Shi, Renjie
   Sun, Keyu
   Li, Runnan
   Liu, Xiao
   Liu, Xuebo
TI Tea polyphenols direct Bmal1-driven ameliorating of the redox imbalance
   and mitochondrial dysfunction in hepatocytes
SO FOOD AND CHEMICAL TOXICOLOGY
LA English
DT Article
DE Tea polyphenols; Circadian clock; Oxidative stress; Mitochondrial
   function; Nrf2/ARE/HO-1; Bmal1
ID TRANSCRIPTIONAL SIGNALING PATHWAY; BV-2 MICROGLIAL CELLS; HIGH-FAT DIET;
   CIRCADIAN CLOCK; OXIDATIVE STRESS; METABOLIC SYNDROME; GENE-EXPRESSION;
   PROTEIN BMAL1; CARE WORKERS; MICE
AB Circadian rhythms are intimately linked to cellular redox status homeostasis via the regulation of mitochondrial function. Tea polyphenols (TP) are nutraceuticals that possess powerful antioxidant properties, especially ameliorating oxidative stress. The objective of this study was to investigate whether circadian clock is involved in the protection effect of TP on oxidative stress cell models. TP ameliorate H2O2-triggered relatively shallow daily oscillations and phase shift of circadian clock genes transcription and protein expression. Meanwhile, TP attenuate H2O2-stimulated excessive secretions of reactive oxygen species (ROS) and restore the depletions of mitochondrial function in a Bmal1-dependent manner. Furthermore, TP treatment accelerates nuclear translocation of Nrf2 and modulates the downstream expressions of antioxidant enzymes. Intriguingly, knockdown of Bmal1 notably blocked Nrf2/ARE/HO-1 redox-sensitive transcription pathway. Our study revealed that TP, as a Bmal1-enhancing natural compound, alleviated redox imbalance via strengthening Keapl/Nrf2 antioxidant defense pathway and ameliorating mitochondrial dysfunction in a Bmal1-dependent manner.
C1 [Qi, Guoyuan; Wu, Wanqiang; Mi, Yashi; Shi, Renjie; Sun, Keyu; Li, Runnan; Liu, Xiao; Liu, Xuebo] Northwest A&F Univ, Coll Food Sci & Engn, Lab Funct Chem & Nutr Food, Yangling 712100, Shaanxi, Peoples R China.
C3 Northwest A&F University - China
RP Liu, XB (corresponding author), Northwest A&F Univ, Coll Food Sci & Engn, 28 Xi Nong Rd, Yangling 712100, Shaanxi, Peoples R China.
EM xueboliu@aliyun.com
RI Wu, Wanqiang/LFR-5674-2024; /AAZ-9695-2020
OI Li., Runnan/0009-0007-6655-2325
FU National Key Research and Development Program of China [2016YFD0400601];
   National Natural Science Foundation of China [31571842]
FX This work was supported by grants from the National Key Research and
   Development Program of China (No. 2016YFD0400601) and the National
   Natural Science Foundation of China (No.31571842).
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NR 54
TC 29
Z9 30
U1 3
U2 40
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0278-6915
EI 1873-6351
J9 FOOD CHEM TOXICOL
JI Food Chem. Toxicol.
PD DEC
PY 2018
VL 122
BP 181
EP 193
DI 10.1016/j.fct.2018.10.031
PG 13
WC Food Science & Technology; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Toxicology
GA HA0JG
UT WOS:000449893700019
PM 30316844
DA 2025-06-11
ER

PT J
AU van der Valk, ES
   Savas, M
   van Rossum, EFC
AF van der Valk, Eline S.
   Savas, Mesut
   van Rossum, Elisabeth F. C.
TI Stress and Obesity: Are There More Susceptible Individuals?
SO CURRENT OBESITY REPORTS
LA English
DT Article
DE Obesity; Stress; Cortisol; Hair cortisol; Glucocorticoid receptor;
   Glucocorticoid receptor polymorphisms; Corticosteroids
ID GLUCOCORTICOID-RECEPTOR GENE; PITUITARY-ADRENAL AXIS; TERM
   CORTISOL-LEVELS; MAJOR DEPRESSIVE DISORDER; HAIR CORTISOL; METABOLIC
   SYNDROME; SCALP HAIR; HPA AXIS; CUSHINGS-SYNDROME; 11-BETA-HSD1
   INHIBITORS
AB Purpose of Review Stress has long been suspected to be interrelated to (abdominal) obesity. However, interindividual differences in this complex relationship exist. We suggest that the extent of glucocorticoid action partly explains these interindividual differences. We provide latest insights with respect to multiple types of stressors.
   Recent Findings Increased long-term cortisol levels, as measured in scalp hair, are strongly related to abdominal obesity and to specific mental disorders. However, not all obese patients have elevated cortisol levels. Possibly, the interindividual variation in glucocorticoid sensitivity, which is partly genetically determined, may lead to higher vulnerability to mental or physical stressors. Other evidence for the important role for increased glucocorticoid action is provided by recent studies investigating associations between body composition and local and systemic corticosteroids.
   Summary Stress may play a major role in the development and maintenance of obesity in individuals who have an increased glucocorticoid exposure or sensitivity. These insights may lead to more effective and individualized obesity treatment strategies.
C1 [van der Valk, Eline S.; Savas, Mesut; van Rossum, Elisabeth F. C.] Univ Med Ctr Rotterdam, Erasmus MC, Obes Ctr CGG, Room D-428,POB 2040, NL-3000 CA Rotterdam, Netherlands.
   [van der Valk, Eline S.; Savas, Mesut; van Rossum, Elisabeth F. C.] Univ Med Ctr Rotterdam, Erasmus MC, Dept Internal Med, Div Endocrinol, Rotterdam, Netherlands.
C3 Erasmus University Rotterdam; Erasmus MC; Erasmus University Rotterdam;
   Erasmus MC
RP van Rossum, EFC (corresponding author), Univ Med Ctr Rotterdam, Erasmus MC, Obes Ctr CGG, Room D-428,POB 2040, NL-3000 CA Rotterdam, Netherlands.; van Rossum, EFC (corresponding author), Univ Med Ctr Rotterdam, Erasmus MC, Dept Internal Med, Div Endocrinol, Rotterdam, Netherlands.
EM e.vanrossum@erasmusmc.nl
RI van Rossum, Elisabeth/AAP-9388-2020; Savas, Mesut/AAE-6955-2021
OI van Rossum, Elisabeth/0000-0003-0120-4913; van der Valk,
   Eline/0000-0001-5134-5453
FU Netherlands Organization of Scientific Research NWO [91716453]
FX EFCvR is supported by a Vidi grant from the Netherlands Organization of
   Scientific Research NWO (grant number: 91716453).
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NR 114
TC 212
Z9 234
U1 1
U2 24
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 2162-4968
J9 CURR OBES REP
JI Curr. Obes. Rep.
PD JUN
PY 2018
VL 7
IS 2
BP 193
EP 203
DI 10.1007/s13679-018-0306-y
PG 11
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA GG3XX
UT WOS:000432628100012
PM 29663153
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Donker, FJS
   Breteler, MHM
AF Donker, FJS
   Breteler, MHM
TI Blood lipids: A shortcut from hostility to CHD?
SO PSYCHOLOGY & HEALTH
LA English
DT Article
DE hostility; serum lipids; coronary artery disease; triglycerides;
   metabolic syndrome
ID CORONARY-HEART-DISEASE; DENSITY-LIPOPROTEIN CHOLESTEROL; ACUTE
   MYOCARDIAL-INFARCTION; RISK-FACTORS; METABOLIC SYNDROME; ARTERY-DISEASE;
   FOLLOW-UP; BEHAVIOR PATTERN; ANGER EXPRESSION; PRONE BEHAVIOR
AB The present article describes the associations between hostility and serum lipids in Coronary Artery Disease (CAD) patients. A sample of 212 male coronary patients was used of which 127 recently suffered a Myocardial Infarction (MI), and 85 had undergone either a Coronary Artery Bypass Grafting (CABG) or a Percutaneous Transluminal Coronary Angioplasty (PTCA). Total Cholesterol (TC), High Density Lipoprotein (HDL), Low Density Lipoprotein (LDL) and triglyceride concentrations were measured as well as four hostility factors: 'Negative Affectivity' (NA), 'Anger-In' (AI), 'Anger-Out' (AO) and Coping, i.e. behaviors to control feelings of anger and anxiety. The results indicated that the effects of hostility on lipids were mediated by various factors such as body weight in relation to body length (BMI), Socio-Economic Status (SES), Left Ventricle Ejection Fraction (LVEF) and Age. In subgroups of highly exhausted patients or of patients scoring high on the Type A Behavior Pattern (TABP), however, more direct (unilinear) associations between lipids and hostility were found. The findings of the present study confirm the rather weak association between hostility and blood lipids found elsewhere. Furthermore, a low level of triglycerides was consistently associated with low AO, be it again in interaction with BMI (AO x BMI), both in the group of non-MI patients and in the total sample for those patients who score high on vital exhaustion and/or TABP. This finding provides an extra argument against the popular notion of the healthfulness under all circumstances of anger expression. Until now the exact role of triglycerides as a function of anger/hostility has been under-explored. This issue merits further attention in future research.
C1 Univ Nijmegen, Dept Clin Psychol, NL-6500 HE Nijmegen, Netherlands.
   Maxima Med Ctr, Dept Med Psychol, NL-5500 MB Veldhoven, Netherlands.
C3 Radboud University Nijmegen; Maxima Medical Center
RP Donker, FJS (corresponding author), Univ Nijmegen, Dept Clin Psychol, Montessorilaan 3, NL-6500 HE Nijmegen, Netherlands.
EM F.Donker@mmc.nl
RI Breteler, Marinus/E-6313-2011
CR [Anonymous], CORONARY RISK FACTOR
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NR 73
TC 4
Z9 4
U1 0
U2 8
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 0887-0446
J9 PSYCHOL HEALTH
JI Psychol. Health
PD APR
PY 2004
VL 19
IS 2
BP 197
EP 212
DI 10.1080/08870440310001627126
PG 16
WC Public, Environmental & Occupational Health; Psychology,
   Multidisciplinary
WE Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; Psychology
GA 800SW
UT WOS:000220049000005
DA 2025-06-11
ER

PT J
AU Aztatzi-Aguilar, OG
   Sierra-Vargas, MP
   Ortega-Romero, M
   Jiménez-Corona, AE
AF Gamaliel Aztatzi-Aguilar, Octavio
   Patricia Sierra-Vargas, Martha
   Ortega-Romero, Manolo
   Eunice Jimenez-Corona, Azucena
TI Osteopontin's relationship with malnutrition and oxidative stress in
   adolescents. A pilot study
SO PLOS ONE
LA English
DT Article
AB Osteopontin (OPN) is a protein involved in inflammatory illnesses such as fibrosis and cancer; its overexpression in cardiovascular diseases promotes the biomineralization of blood vessels and other soft tissues. Moreover, there is an active component of oxidative stress related with those diseases. The present study relates serum OPN levels with nutritional condition and oxidative stress in a group of adolescents. Anthropometric measurements were performed, and fasting blood samples were analyzed to determine OPN concentrations, blood chemistry parameters (glucose, triglycerides, total cholesterol, urea, uric acid, and creatinine) and oxidative stress biomarkers (Paraoxonase-1, Glutathione S-Transferase, Catalase, NAD(P)H Quinone Oxidoreductase, free carbonyl groups and malondialdehyde). Adolescents were categorized according to body mass index (BMI) and metabolic syndrome (MetS) criteria. We found increased OPN serum concentrations in overweight and obese adolescents, as well as in adolescents with MetS. Rises in OPN correlated with arm circumference and biomarkers of lipid peroxidation; with regard to serum glucose there was a trend to positive correlation. Our results suggest that serum OPN is associated to nutritional status and could be considered as an early biomarker of low-grade inflammation and probably the early biomineralization of soft tissues in adolescence.
C1 [Gamaliel Aztatzi-Aguilar, Octavio; Patricia Sierra-Vargas, Martha] Inst Nacl Enfermedades Resp Ismael Cosio Villegas, Dept Invest Toxicol & Med Ambiental, Cdmx, Mexico.
   [Gamaliel Aztatzi-Aguilar, Octavio] Catedras CONACyT, Cdmx, Mexico.
   [Patricia Sierra-Vargas, Martha] La Salle Univ, Fac Mexicana Med, Cdmx, Mexico.
   [Ortega-Romero, Manolo] Inst Politecn Nacl, Ctr Invest & Estudios Avanzados, Cdmx, Mexico.
   [Eunice Jimenez-Corona, Azucena] Univ Autonoma Estado Hidalgo, Escuela Super Huejutla, Huejutla, Hidalgo, Mexico.
C3 Consejo Nacional de Ciencia y Tecnologia (CONACyT); Universidad Autonoma
   del Estado de Hidalgo
RP Sierra-Vargas, MP (corresponding author), Inst Nacl Enfermedades Resp Ismael Cosio Villegas, Dept Invest Toxicol & Med Ambiental, Cdmx, Mexico.; Sierra-Vargas, MP (corresponding author), La Salle Univ, Fac Mexicana Med, Cdmx, Mexico.; Jiménez-Corona, AE (corresponding author), Univ Autonoma Estado Hidalgo, Escuela Super Huejutla, Huejutla, Hidalgo, Mexico.
EM mpsierra@iner.gob.mx; azucena_jimenez@uaeh.edu.mx
RI Sierra Vargas, Martha Patricia/C-5097-2018
OI Sierra Vargas, Martha Patricia/0000-0002-1894-745X; Aztatzi-Aguilar,
   Octavio Gamaliel/0000-0003-1761-9443; de la cruz hernandez, cinthia
   yarely/0000-0003-0066-1725; Jimenez-Corona, Azucena
   E./0000-0002-8987-506X
FU PRODEP (Programa para el Desarrollo Profesional Docente para el tipo
   Superior, Secretaria de Educacion Publica grant) [UAEH-PTC763]
FX This research was funded by grants from the PRODEP (Programa para el
   Desarrollo Profesional Docente para el tipo Superior, Secretaria de
   Educacion Publica grant UAEH-PTC763). The funders had no role in study
   design, data collection and analysis, decision to publish, or
   preparation of the manuscript.
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NR 49
TC 7
Z9 7
U1 0
U2 3
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAR 25
PY 2021
VL 16
IS 3
AR e0249057
DI 10.1371/journal.pone.0249057
PG 15
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA RF4TN
UT WOS:000634832800074
PM 33765028
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Rastrelli, G
   Corona, G
   Maggi, M
AF Rastrelli, Giulia
   Corona, Giovanni
   Maggi, Mario
TI The role of prolactin in andrology: what is new?
SO REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
LA English
DT Review
DE Prolactin; Serotonin; Man; Metabolism; Sexuality
ID SEROTONIN TRANSPORTER GENE; INDUCED PENILE ERECTIONS; MALE
   SEXUAL-BEHAVIOR; GROWTH-HORMONE; PLASMA PROLACTIN; RECEPTOR GENE;
   METABOLIC SYNDROME; PARAVENTRICULAR NUCLEUS; CEREBROSPINAL-FLUID; PRL
   RECEPTOR
AB Prolactin (PRL) has been long deemed as a hormone involved only in female reproduction. However, PRL is a surprising hormone and, since its identification in the 1970s, its attributed functions have greatly increased. However, its specific role in male health is still widely unknown. Recently, low PRL has been associated with reduced ejaculate and seminal vesicle volume in infertile subjects. In addition, in men consulting for sexual dysfunction, hypoprolactinemia has been associated with erectile dysfunction and premature ejaculation, findings further confirmed in the general European population and infertile men. Several metabolic derangements, recapitulating metabolic syndrome, have also been associated with low PRL both in men with sexual dysfunction and from the general European population. In men with sexual dysfunction, followed-up for more than 4 years, low PRL was identified as an independent predictor of the incidence of major adverse cardiovascular events. Finally, an association with anxiety or depressive symptoms has been found in men with sexual dysfunction and from the general European population. While a direct role for impaired PRL function in the pathogenesis of these reproductive, sexual, metabolic and psychological disorders is conceivable, the possibility that low PRL is a mirror of an increased dopaminergic or a decreased serotonergic tone cannot be ruled-out. Hyperactivity of the dopaminergic system can explain only a few of the aforementioned findings, whereas a hypo-serotonergic tone fits well with the clinical features associated with low PRL, and there is significant evidence supporting the hypothesis that PRL could be a mirror of serotonin in the brain.
C1 [Rastrelli, Giulia; Corona, Giovanni; Maggi, Mario] Univ Florence, Dept Expt & Clin Biomed Sci, Sexual Med & Androl Unit, I-50139 Florence, Italy.
   [Corona, Giovanni] Maggiore Hosp, Endocrinol Sect, I-40133 Bologna, Italy.
C3 University of Florence; AUSL di Bologna
RP Maggi, M (corresponding author), Univ Florence, Dept Expt & Clin Biomed Sci, Sexual Med & Androl Unit, Viale Pieraccini 6, I-50139 Florence, Italy.
EM mario.maggi@unifi.it
RI Maggi, Mario/AAB-8284-2019
OI Rastrelli, Giulia/0000-0002-6164-4278; MAGGI, Mario/0000-0003-3267-4221
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NR 239
TC 51
Z9 53
U1 0
U2 10
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1389-9155
EI 1573-2606
J9 REV ENDOCR METAB DIS
JI Rev. Endocr. Metab. Disord.
PD SEP
PY 2015
VL 16
IS 3
BP 233
EP 248
DI 10.1007/s11154-015-9322-3
PG 16
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA CZ9OW
UT WOS:000367427900005
PM 26542707
DA 2025-06-11
ER

PT J
AU Carrier, P
   Debette-Gratien, M
   Girard, M
   Jacques, J
   Nubukpo, P
   Loustaud-Ratti, V
AF Carrier, Paul
   Debette-Gratien, Marilyne
   Girard, Murielle
   Jacques, Jeremie
   Nubukpo, Philippe
   Loustaud-Ratti, Veronique
TI Liver Illness and Psychiatric Patients
SO HEPATITIS MONTHLY
LA English
DT Review
DE Viral Hepatitis; Non-Alcoholic Fatty Liver Disease; Mental Disorders;
   Hepatotoxicity
ID SEVERE MENTAL-ILLNESS; HEPATITIS-C INFECTION; NONALCOHOLIC
   STEATOHEPATITIS; WILSONS-DISEASE; CANNABIS USE; RISK-FACTORS;
   DEPRESSION; FAILURE; TRANSPLANTATION; HEPATOTOXICITY
AB Patients with psychiatric disorders are usually more exposed to multiple somatic illnesses, including liver diseases. Specific links are established between psychiatric disorders and alcohol hepatitis, hepatitis B, and hepatitis C in the population as a whole, and specifically in drug abusers. Metabolic syndrome criteria, and associated steatosis or non-alcoholic steato-hepatitis (NASH) are frequent in patients with chronic psychiatric disorders under psychotropic drugs, and should be screened. Some psychiatric medications, such as neuroleptics, mood stabilizers, and a few antidepressants, are often associated with drug-induced liver injury (DILI). In patients with advanced chronic liver diseases, the prescription of some specific psychiatric treatments should be avoided. Psychiatric disorders can be a limiting factor in the decision-making and following up for liver transplantation.
C1 [Carrier, Paul; Debette-Gratien, Marilyne; Jacques, Jeremie; Loustaud-Ratti, Veronique] CHU Limoges, Serv Hepatogastroenterol, F-87042 Limoges, France.
   [Carrier, Paul; Debette-Gratien, Marilyne; Loustaud-Ratti, Veronique] Univ Limoges, INSERM, U850, F-87000 Limoges, France.
   [Girard, Murielle] Ctr Hosp Specialise Esquirol, Unite Invest Clin, F-87042 Limoges, France.
   [Nubukpo, Philippe] Ctr Hosp Specialise Esquirol, Pole Addictol, F-87042 Limoges, France.
C3 CHU Limoges; Universite de Limoges; Institut National de la Sante et de
   la Recherche Medicale (Inserm)
RP Carrier, P (corresponding author), CHU Limoges, Serv Hepatogastroenterol, F-87042 Limoges, France.
EM pcarrier@hotmail.fr
RI Nubukpo, Philippe/KXR-1904-2024; Carrier, Paul/A-2106-2017
OI JACQUES, Jeremie/0000-0003-4105-6804; Girard,
   Murielle/0000-0003-1222-0329
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NR 80
TC 17
Z9 17
U1 0
U2 38
PU KOWSAR PUBL
PI HOENSBROEK
PA PATERSWEG 22,, HOENSBROEK, LIMBURG 6431 GC, NETHERLANDS
SN 1735-143X
EI 1735-3408
J9 HEPAT MON
JI Hepat. Mon.
PD DEC
PY 2016
VL 16
IS 12
AR e41564
DI 10.5812/hepatmon.41564
PG 9
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA EI1GZ
UT WOS:000392226300005
PM 28123443
OA Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Kammoun, HL
   Hainault, I
   Ferré, P
   Foufelle, F
AF Kammoun, Helene L.
   Hainault, Isabelle
   Ferre, Pascal
   Foufelle, Fabienne
TI Nutritional related liver disease: targeting the endoplasmic reticulum
   stress
SO CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE
LA English
DT Article
DE endoplasmic reticulum stress; hepatic steatosis; metabolic syndrome;
   NAFLD
ID UNFOLDED PROTEIN RESPONSE; ELEMENT-BINDING PROTEIN-1C; C-REACTIVE
   PROTEIN; ER STRESS; INSULIN-RESISTANCE; HEPATIC STEATOSIS; NONALCOHOLIC
   STEATOHEPATITIS; GENE-EXPRESSION; INFLAMMATORY RESPONSE;
   GLUCOSE-HOMEOSTASIS
AB Purpose of review
   Nutritional hepatic disorders are spreading worldwide associated to obesity and type 2 diabetes. The underlying mechanisms leading to the development of hepatic steatosis and its complications are not fully understood. The endoplasmic reticulum (ER) stress response has recently been proposed to play a crucial role in the setting of these pathologies. This review will evaluate the late discoveries highlighting ER stress as a major actor in the development of nutritional liver diseases.
   Recant findings
   Activation of ER stress has been reported in the fatty liver of obese rodents and obese individuals. The mechanisms by which ER stress leads to the development of hepatic steatosis have been recently documented. ER stress has been shown to directly activate the lipogenic transcription factor SREBP-1c (sterol regulatory element binding protein-1c) conducting to an induction of the lipogenic pathway. ER stress activation is also associated with impaired VLDL (very low density lipoprotein) secretion. ER stress could also have a role in hepatic steatosis progression by triggering inflammation and fibrosis. In rodents, therapies aiming to reduce ER stress have fully demonstrated their efficiency in the treatment of hepatic steatosis.
   Summary
   ER stress has been recently involved in the development of hepatic steatosis. Thus, ER stress could represent in the future an eligible therapeutic target for the treatment of nonalcoholic fatty liver disease. However, as ER stress is a fundamental mechanism involved in cell survival, any modification of this pathway must be carefully assessed.
C1 [Foufelle, Fabienne] INSERM, UMR S 872, Ctr Rech Cordeliers, F-75006 Paris, France.
   Univ Paris 06, UMR S 872, Paris, France.
C3 Universite Paris Cite; Sorbonne Universite; Institut National de la
   Sante et de la Recherche Medicale (Inserm); Sorbonne Universite;
   Universite Paris Cite
RP Foufelle, F (corresponding author), INSERM, UMR S 872, Ctr Rech Cordeliers, 15 Rue Ecole Med, F-75006 Paris, France.
EM fabienne.foufelle@crc.jussieu.fr
OI FOUFELLE, Fabienne/0000-0002-0752-622X
FU INSERM; Agence Nationale de la Recherche [ANR-2005-PCOD-035]; Alfediam
   Takeda; European Commission [LSHM-CT-2004-005272]; Ministere de la
   Recherche et de l'Enseignement superieur
FX This work was supported by grants from INSERM, from the Agence Nationale
   de la Recherche (ANR-2005-PCOD-035), from Alfediam Takeda and from the
   EXGENESIS Integrated Project Grant LSHM-CT-2004-005272 funded by the
   European Commission. H.L.K. is a recipient of a doctoral fellowship from
   the Ministere de la Recherche et de l'Enseignement superieur.
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NR 58
TC 32
Z9 36
U1 0
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1363-1950
EI 1473-6519
J9 CURR OPIN CLIN NUTR
JI Curr. Opin. Clin. Nutr. Metab. Care
PD NOV
PY 2009
VL 12
IS 6
BP 575
EP 582
DI 10.1097/MCO.0b013e32833189db
PG 8
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 513BI
UT WOS:000271296600003
PM 19726979
DA 2025-06-11
ER

PT J
AU Leboyer, M
   Godin, O
   Llorca, PM
   Aubin, V
   Bellivier, F
   Belzeaux, R
   Courtet, P
   Costagliola, D
   Dubertret, C
   M'Bailara, K
   Haffen, E
   Henry, C
   Laouamri, H
   Passerieux, C
   Pelletier, A
   Polosan, M
   Roux, P
   Schwan, R
   Samalin, L
   Olié, E
   Etain, B
AF Leboyer, M.
   Godin, O.
   Llorca, P. M.
   Aubin, V
   Bellivier, F.
   Belzeaux, R.
   Courtet, P.
   Costagliola, D.
   Dubertret, C.
   M'Bailara, K.
   Haffen, E.
   Henry, C.
   Laouamri, H.
   Passerieux, C.
   Pelletier, A.
   Polosan, M.
   Roux, P.
   Schwan, R.
   Samalin, L.
   Olie, E.
   Etain, Bruno
CA Fondamental Adv Ctr Expertise Bipo
TI Key findings on bipolar disorders from the longitudinal FondaMental
   Advanced Center of Expertise-Bipolar Disorder (FACE-BD) cohort
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Bipolar disorders; Cohort; Longitudinal; Course; Biomarkers; Environment
ID REACTIVE PROTEIN ALTERATIONS; METABOLIC SYNDROME; SLEEP QUALITY;
   EMOTIONAL REACTIVITY; EUTHYMIC PATIENTS; MEDICATION; ADHERENCE; RISK;
   METAANALYSIS; PREVALENCE
AB Background: The FACE-BD cohort is an observational cohort of individuals with bipolar disorders (BD) who benefited from a systematic evaluation with evidence-based treatment recommendations and who were followed-up every year for 3 years in France. The objectives were to describe the lifetime course of BD, associated psychiatric and somatic comorbidities, and cognition profile. This cohort aims to identify clinical/biological signatures of outcomes, trajectories of functioning and transition between clinical stages. This article summarizes 10 years of findings of the FACE-BD cohort.Method & results: We included 4422 individuals, all having a baseline assessment, among which 61.2% had at least one follow-up visit at either one, two or three years. A subsample of 1200 individuals had at least one biological sample (serum, plasma, DNA). Assessments include family history of psychiatric disorders, psychiatric diagnosis, current mood symptoms, functioning, hospitalizations, suicidal attempts, physical health, routine blood tests, treatment history, psychological dimensions, medico-economic data and a cognitive assessment. Studies from this cohort illustrate that individuals with BD display multiple coexistent psychiatric associated conditions including sleep disturbances, anxiety disorders, substance use disorders and suicide attempts as well as a high prevalence of metabolic syndrome. During follow-up, we observed a 55% reduction of the number of days of hospitalization and a significant improvement in functioning.Conclusions: The FACE-BD cohort provides a strong research infrastructure for clinical research in BD and has a unique position among international cohorts because of its comprehensive clinical assessment and sustainable funding from the French Ministry of Health.
C1 [Leboyer, M.; Godin, O.; Pelletier, A.] Univ Paris Est Creteil, Translat Neuro Psychiat, IMRB, INSERM U955, F-94010 Creteil, France.
   [Leboyer, M.; Godin, O.; Pelletier, A.] Hop Univ Henri Mondor, AP HP, Dept Med Univ Psychiat & Addictol DMU IMPACT, Federat Hospitalo Univ Med Precis Psychiat FHU AD, F-94010 Creteil, France.
   [Leboyer, M.; Godin, O.; Llorca, P. M.; Aubin, V; Bellivier, F.; Belzeaux, R.; Courtet, P.; Dubertret, C.; M'Bailara, K.; Haffen, E.; Henry, C.; Laouamri, H.; Passerieux, C.; Pelletier, A.; Polosan, M.; Roux, P.; Schwan, R.; Samalin, L.; Olie, E.; Etain, Bruno] Fdn FondaMental, Creteil, France.
   [Llorca, P. M.; Samalin, L.] Univ Clermont Auvergne, UMR 6602 Inst Pascal IP, Dept Psychiat, CHU Clermont Ferrand, Clermont Ferrand, France.
   [Aubin, V] Ctr Hosp Princesse Grace, Pole Psychiat, Monaco, Monaco.
   [Bellivier, F.; Etain, Bruno] Univ Paris, Paris, France.
   [Bellivier, F.; Etain, Bruno] Hop Fernand Widal, AP HP, Grp Hospitalo Univ AP HP Nord, DMU Neurosci,Dept Psychiat & Med Addictol, Paris, France.
   [Bellivier, F.; Etain, Bruno] INSERM UMRS 1144, Paris, France.
   [Belzeaux, R.] Assistance Publ HOp Marseille, Pole Psychiat, Marseille, France.
   [Belzeaux, R.] Aix Marseille Univ, INT UMR7289, CNRS, Marseille, France.
   [Courtet, P.; Olie, E.] Univ Montpellier, Dept Emergency Psychiat & Acute Care, INSERM, CNRS,CHU Montpellier,IGF, Montpellier, France.
   [Costagliola, D.] Sorbonne Univ, Inst Pierre Louis Epidemiol & Sante Publ IPLESP, INSERM, Paris, France.
   [Dubertret, C.] Univ Paris, Hop Louis Mourier, AP HP,Grp Hospitalo Univ AP HP Nord, INSERM UMR1266,DMU Esprit,Serv Psychiat & Addicto, Colombes, France.
   [M'Bailara, K.] Univ Bordeaux, LabPsy, EA 4139, F-33000 Bordeaux, France.
   [M'Bailara, K.] Ctr Hosp Charles Perrens, Pole 3-4-7,121 Rue Bechade, Bordeaux, France.
   [Haffen, E.] CHU Besancon, Dept Psychiat Clin, CIC 1431 INSERM, Besancon, France.
   [Haffen, E.] Univ Bourgogne Franche Comte, EA481 Neurosci, Besancon, France.
   [Henry, C.] GHU Paris Psychiat & Neurosci, Dept Psychiat, Serv Hospitalo Univ, F-75014 Paris, France.
   [Passerieux, C.; Roux, P.] Univ Paris Saclay, Univ Versailles St Quentin En Yvelines, Serv Hospitalo Univ Psychiat Adulte & Addictol, Ctr Hosp Versailles,INSERM UMR1018,DisAP DevPsy C, Paris, France.
   [Polosan, M.] Univ Grenoble Alpes, Grenoble Inst Neurosci Gin Inserm U 1216, CHU Grenoble & Alpes, Grenoble, France.
   [Schwan, R.] Univ Lorraine, Pole Hospitalo Univ Psychiat Adultes & Addictol, CPN Laxou, Inserm U 1114, Nancy, France.
C3 Universite Paris-Est-Creteil-Val-de-Marne (UPEC); Institut National de
   la Sante et de la Recherche Medicale (Inserm); Universite
   Paris-Est-Creteil-Val-de-Marne (UPEC); Assistance Publique Hopitaux
   Paris (APHP); Hopital Universitaire Henri-Mondor - APHP; Universite
   Clermont Auvergne (UCA); CHU Clermont Ferrand; Universite Paris Cite;
   Assistance Publique Hopitaux Paris (APHP); Universite Paris Cite;
   Hopital Universitaire Saint-Louis - APHP; Hopital Universitaire
   Lariboisiere-Fernand-Widal - APHP; Institut National de la Sante et de
   la Recherche Medicale (Inserm); Universite Paris Cite; Aix-Marseille
   Universite; Assistance Publique-Hopitaux de Marseille; Aix-Marseille
   Universite; Centre National de la Recherche Scientifique (CNRS); CNRS -
   National Institute for Biology (INSB); Centre National de la Recherche
   Scientifique (CNRS); Universite de Montpellier; Institut National de la
   Sante et de la Recherche Medicale (Inserm); CHU de Montpellier; Institut
   National de la Sante et de la Recherche Medicale (Inserm); Sorbonne
   Universite; Assistance Publique Hopitaux Paris (APHP); Universite Paris
   Cite; Hopital Universitaire Louis-Mourier - APHP; Institut National de
   la Sante et de la Recherche Medicale (Inserm); Universite de Bordeaux;
   Institut National de la Sante et de la Recherche Medicale (Inserm);
   Universite de Franche-Comte; CHU Besancon; Universite de Franche-Comte;
   Universite Paris Cite; GHU PARIS Psychiatrie Neurosciences; Universite
   Paris Saclay; Institut National de la Sante et de la Recherche Medicale
   (Inserm); Centre Hospitalier de Versailles; Communaute Universite
   Grenoble Alpes; Universite Grenoble Alpes (UGA); CHU Grenoble Alpes;
   Universite de Lorraine; Institut National de la Sante et de la Recherche
   Medicale (Inserm)
RP Leboyer, M (corresponding author), Hop Albert Chenevier, Dept Hospitalo Univ Psychiat, 40 Rue Mesly, F-94000 Creteil, France.
EM marion.leboyer@inserm.fr
RI Roux, Paul/B-5795-2013; haffen, emmanuel/R-2765-2017; Fond,
   Guillaume/D-7646-2011; BELLIVIER, FRANK/H-5197-2012; Samalin,
   Ludovic/AAP-6362-2020; Polosan, Mircea/MGV-2270-2025; Etain,
   Bruno/L-6647-2017; Costagliola, Dominique/H-5849-2011
OI Etain, Bruno/0000-0002-5377-1488; BELLIVIER, FRANK/0000-0002-3660-6640;
   Costagliola, Dominique/0000-0003-0765-0869; Samalin,
   Ludovic/0000-0003-0740-4019
FU Foundation FondaMental, Institut National de la Sante et de la Recherche
   Medicale (INSERM), AP-HP; Investissements d'Avenir program
   [ANR-11-IDEX-0004-02, ANR-10-COHO-10-01]
FX This research was supported by the Foundation FondaMental, Institut
   National de la Sante et de la Recherche Medicale (INSERM), AP-HP, and by
   the Investissements d'Avenir program managed by the ANR under reference
   ANR-11-IDEX-0004-02 and ANR-10-COHO-10-01. This funding source had no
   role in the study design, data collection, analysis, preparation of the
   manuscript, or decision to submit the manuscript for publication.
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NR 46
TC 13
Z9 13
U1 1
U2 3
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD JUN 15
PY 2022
VL 307
BP 149
EP 156
DI 10.1016/j.jad.2022.03.053
EA APR 2022
PG 8
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA 1V6IN
UT WOS:000806191000018
PM 35339569
OA Green Submitted, Bronze
DA 2025-06-11
ER

PT J
AU Santamaria-Juarez, C
   Atonal-Flores, F
   Diaz, A
   Sarmiento-Ortega, VE
   Garcia-Gonzalez, M
   Aguilar-Alonso, P
   Lopez-Lopez, G
   Brambila, E
   Treviño, S
AF Santamaria-Juarez, Celeste
   Atonal-Flores, Fausto
   Diaz, Alfonso
   Sarmiento-Ortega, Victor E.
   Garcia-Gonzalez, Miguel
   Aguilar-Alonso, Patricia
   Lopez-Lopez, Gustavo
   Brambila, Eduardo
   Trevino, Samuel
TI Aortic dysfunction by chronic cadmium exposure is linked to multiple
   metabolic risk factors that converge in anion superoxide production
SO ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
LA English
DT Article
DE Hypertension; superoxide dismutase; apocynin; vascular reactivity; NADPH
   oxidase
ID ENDOTHELIAL-CELLS ROLE; OXIDATIVE STRESS; NITRIC-OXIDE; BLOOD-PRESSURE;
   DENSITY-LIPOPROTEIN; INSULIN-RESISTANCE; OXIDIZED LDL; FATTY-ACIDS;
   HYPERTENSION; ACCUMULATION
AB Context: The chronic exposure to Cadmium (Cd) constitute an risk to develop hypertension and cardiovascular diseases associated with the increase of oxidative stress. Objective: In this study, we investigate the role of metabolic changes produced by exposure to Cd on the endothelial dysfunction via oxidative stress. Methods: Male Wistar rats were exposed to Cd (32.5-ppm) for 2-months. The zoometry and blood pressure were evaluated, also glucose and lipids profiles in serum and vascular reactivity evaluated in isolated aorta rings. Results: Rats exposed to Cd showed an increase of blood pressure and biochemical parameters similar to metabolic syndrome. Additionally, rats exposed to Cd showed a reduced relaxation in aortic rings, which was reversed after the addition of SOD and apocynin an inhibitor of NADPH. Conclusion: The Cd-exposition induced hypertension and endothelial injury by that modifying the vascular relaxation and develop oxidative stress via NADPH oxidase, superoxide and loss nitric oxide bioavailability.
C1 [Santamaria-Juarez, Celeste; Diaz, Alfonso; Garcia-Gonzalez, Miguel; Lopez-Lopez, Gustavo] Univ Autonomous Puebla, Fac Chem Sci, Dept Pharm, Puebla, Mexico.
   [Atonal-Flores, Fausto] Univ Autonomous Puebla, Fac Med, Dept Physiol, Volcano, Puebla, Mexico.
   [Sarmiento-Ortega, Victor E.; Aguilar-Alonso, Patricia; Brambila, Eduardo; Trevino, Samuel] Univ Autonomous Puebla, Fac Chem Sci, Dept Clin Chem, Lab Chem Clin Invest, 14 South CQ1, Puebla 72560, Mexico.
C3 Benemerita Universidad Autonoma de Puebla; Benemerita Universidad
   Autonoma de Puebla; Benemerita Universidad Autonoma de Puebla
RP Treviño, S (corresponding author), Univ Autonomous Puebla, Fac Chem Sci, Dept Clin Chem, Lab Chem Clin Invest, 14 South CQ1, Puebla 72560, Mexico.
OI Diaz, Alfonso/0000-0003-4092-6636; Garcia-Gonzalez, Miguel
   Angel/0000-0002-0826-2932
FU Vicerrectoria de Investigacion y Estudios de Posgrado (VIEP-BUAP)
   [00027]
FX This work was supported by the Vicerrectoria de Investigacion y Estudios
   de Posgrado (VIEP-BUAP) through Dr. Ygnacio Martinez Laguna for the
   financial support of this research project 00027.
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NR 65
TC 11
Z9 12
U1 1
U2 4
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1381-3455
EI 1744-4160
J9 ARCH PHYSIOL BIOCHEM
JI Arch. Physiol. Biochem.
PD MAY 4
PY 2022
VL 128
IS 3
BP 748
EP 756
DI 10.1080/13813455.2020.1726403
EA FEB 2020
PG 9
WC Biochemistry & Molecular Biology; Biophysics; Endocrinology &
   Metabolism; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Endocrinology &
   Metabolism; Physiology
GA 1U8AJ
UT WOS:000514728800001
PM 32067514
DA 2025-06-11
ER

PT J
AU Liu, XY
   Wang, X
   Wen, CS
   Wan, L
AF Liu, Xiuyan
   Wang, Xiu
   Wen, Chunsong
   Wan, Li
TI Decision tree distinguish affective disorder diagnosis from psychotic
   disorder diagnosis with clinical and lab factors
SO HELIYON
LA English
DT Article
DE Lab factors; Affective disorder; Psychotic disorder; Decision tree;
   Predictive model
ID MAJOR DEPRESSIVE DISORDER; NECROSIS-FACTOR-ALPHA;
   SCHIZOPHRENIA-PATIENTS; METABOLIC SYNDROME; CREATININE LEVELS; SERUM
   BILIRUBIN; CYTOKINE LEVELS; APOLIPOPROTEIN; INTERLEUKIN-6; ASSOCIATIONS
AB Background: Affective symptoms usually occur at the same time of psychotic symptoms. An effective predictive method would help the differential diagnosis at an early stage of the mental disorder. The purpose of the study was to establish a predictive model by using laboratory indexes and clinical factors to improve the diagnostic accuracy. Methods: Subjects were patients diagnosed with psychiatric disorders with affective and/or psychotic symptoms. Two patient samples were collected in the study (n 1/4 309) With three classification methods (logistic regression, decision tree, and discriminant analysis), we established the models and verified the models. Results: Seven predictors were found to be significant to distinguish the affective disorder diagnosis from the psychotic disorder diagnosis in all three methods, the 7 factors were Activities of daily living, direct bilirubin, apolipoproteinA1, lactic dehydrogenase, creatinine, monocyte count and interleukin-8. The decision tree outperformed the other 2 methods in area under the receiver operating characteristic curve, and also had the highest percentage of correctly classification. Conclusion: We established a predictive model that included activities of daily living, biochemical, and immune indicators. In addition, the model established by the decision tree method had the highest predictive power, which provided a reliable basis for future clinical work. Our work would help make diagnosis more accurate at an early stage of the disorder.
C1 [Liu, Xiuyan; Wen, Chunsong; Wan, Li] Anhui Med Univ, Hefei Peoples Hosp 4, Anhui Mental Hlth Ctr, Affiliated Psychol Hosp, Hefei 230026, Anhui, Peoples R China.
   [Liu, Xiuyan; Wen, Chunsong; Wan, Li] Natl Clin Res Ctr Mental Disorders, Anhui Branch, Hefei 230026, Anhui, Peoples R China.
   [Liu, Xiuyan; Wen, Chunsong; Wan, Li] Anhui Clin Res Ctr Mental Disorders, Hefei 230026, Anhui, Peoples R China.
   [Wang, Xiu] Anhui Univ, Hefei 230039, Anhui, Peoples R China.
C3 Anhui Medical University; Anhui University
RP Wan, L (corresponding author), Anhui Med Univ, Hefei Peoples Hosp 4, Anhui Mental Hlth Ctr, Affiliated Psychol Hosp, Hefei 230026, Anhui, Peoples R China.; Wan, L (corresponding author), Natl Clin Res Ctr Mental Disorders, Anhui Branch, Hefei 230026, Anhui, Peoples R China.; Wan, L (corresponding author), Anhui Clin Res Ctr Mental Disorders, Hefei 230026, Anhui, Peoples R China.
EM wanli@ahmu.edu.cn
FU Anhui Medical University School Funding Project [2021xkj235]; Anhui
   Mental Health Center Research Project [HFSY202117]; Hefei Municipal
   Health Commission Applied Medicine Research Project [Hwk2022zd015]
FX This work was supported by the grants from Anhui Medical University
   School Funding Project (2021xkj235) , Anhui Mental Health Center
   Research Project (HFSY202117) , and Hefei Municipal Health Commis- sion
   Applied Medicine Research Project (Hwk2022zd015) .
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NR 54
TC 0
Z9 0
U1 1
U2 2
PU CELL PRESS
PI CAMBRIDGE
PA 50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA
EI 2405-8440
J9 HELIYON
JI Heliyon
PD NOV
PY 2022
VL 8
IS 11
AR e11514
DI 10.1016/j.heliyon.2022.e11514
EA NOV 2022
PG 9
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 7I7ZB
UT WOS:000904106400003
PM 36406667
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Pereira, SS
   Teixeira, LG
   Aguilar, EC
   Matoso, RO
   Soares, FLP
   Ferreira, AVM
   Alvarez-Leite, JI
AF Pereira, Solange S.
   Teixeira, Lilian G.
   Aguilar, Edenil C.
   Matoso, Rafael O.
   Soares, Fabiola L. P.
   Ferreira, Adaliene V. M.
   Alvarez-Leite, Jacqueline I.
TI Differences in adipose tissue inflammation and oxidative status in
   C57BL/6 and ApoE-/- mice fed high fat diet
SO ANIMAL SCIENCE JOURNAL
LA English
DT Article
DE adipocytes; adipokines; metabolic syndrome; obesity; oxidative stress
ID INSULIN-RESISTANCE; DEFICIENT MICE; OBESITY; STRESS; ADIPOCYTES;
   ACCUMULATION
AB Apolipoprotein E deficient (Apo E-/-) mice are more resistant to the development of obesity compared to C57BL/6 wild type mice. They also hold a high basal oxidative status due to the loss of antioxidant action of apolipoprotein E. Since obesity is also an inducer of inflammation, we studied the effect of high-fat diet on obesity and oxidative stress in C57BL/6 and Apo E-/- mice for 9 weeks. The results confirmed that Apo E-/- mice fed high-fat diet are more resistant to the increase of both body weight and adiposity compared to C57BL/6 mice. Despite this, Apo E-/- mice presented a higher basal oxidative stress that was enhanced by high-fat diet. Macrophage infiltration, macrophage forming crown-like structures and proinflammatory adipokines (interleukin 6 and tumor necrosis factor alpha) were all higher in adipose tissue from Apo E-/- compared to C57BL/6 mice, regardless of diet type. In conclusion, although Apo E-/- mice are more resistant to becoming obese, they develop more severe adipose tissue inflammation companied by its consequences.
C1 [Pereira, Solange S.; Teixeira, Lilian G.; Aguilar, Edenil C.; Matoso, Rafael O.; Soares, Fabiola L. P.; Alvarez-Leite, Jacqueline I.] Univ Fed Minas Gerais, Biochem & Immunol Dept, Atherosclerosis & Nutr Biochem Lab, Belo Horizonte, MG, Brazil.
   [Ferreira, Adaliene V. M.] Univ Fed Minas Gerais, Nursing Basic Dept, Sch Nursing, Belo Horizonte, MG, Brazil.
   [Pereira, Solange S.; Soares, Fabiola L. P.] Univ Fed Minas Gerais, Sch Pharm, Food Sci Dept, Belo Horizonte, MG, Brazil.
C3 Universidade Federal de Minas Gerais; Universidade Federal de Minas
   Gerais; Universidade Federal de Minas Gerais
RP Pereira, SS (corresponding author), Univ Fed Minas Gerais, Biochem & Immunol Dept, Atherosclerosis & Nutr Biochem Lab, Av Antonio Carlos,6627 Pampulha, Belo Horizonte, MG, Brazil.
EM solangesilveirapereira@yahoo.com.br
RI Teixeira, Lílian/CAI-1620-2022; Ferreira, adaliene/G-8523-2011;
   ALVAREZ-LEITE, JACQUELINE/C-9175-2014
OI Ferreira, adaliene/0000-0003-2256-8652; S. Pereira,
   Solange/0000-0002-3146-6992; ALVAREZ-LEITE,
   JACQUELINE/0000-0001-6601-9853
FU CNPq (Conselho Nacional de Desenvolvimento Cientifico e Tecnologico);
   CAPES (Cordenacao de Aperfeicoamento de Pessoal de Nivel Superior);
   FAPEMIG (Fundacao de Amparo a Pesquisa de Minas Gerais)
FX This study was supported by Brazilian funds from CNPq (Conselho Nacional
   de Desenvolvimento Cientifico e Tecnologico), CAPES (Cordenacao de
   Aperfeicoamento de Pessoal de Nivel Superior) and FAPEMIG (Fundacao de
   Amparo a Pesquisa de Minas Gerais).
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NR 28
TC 28
Z9 31
U1 0
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1344-3941
EI 1740-0929
J9 ANIM SCI J
JI Anim. Sci. J.
PY 2012
VL 83
IS 7
BP 549
EP 555
DI 10.1111/j.1740-0929.2011.00982.x
PG 7
WC Agriculture, Dairy & Animal Science
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture
GA 971QZ
UT WOS:000306220200005
PM 22776793
DA 2025-06-11
ER

PT J
AU Heslin, M
   Patel, A
   Stahl, D
   Gardner-Sood, P
   Mushore, M
   Smith, S
   Greenwood, K
   Onagbesan, O
   O'Brien, C
   Fung, C
   Ohlsen, R
   Hopkins, D
   Lowe, P
   Arbuthnot, M
   Mutatsa, S
   Todd, G
   Kolliakou, A
   Lally, J
   Stubbs, B
   Ismail, K
   David, A
   Murray, R
   Atakan, Z
   Gaughran, F
AF Heslin, Margaret
   Patel, Anita
   Stahl, Daniel
   Gardner-Sood, Poonam
   Mushore, Manyara
   Smith, Shubulade
   Greenwood, Kathryn
   Onagbesan, Oluwadamilola
   O'Brien, Conan
   Fung, Catherine
   Ohlsen, Ruth
   Hopkins, David
   Lowe, Philippa
   Arbuthnot, Maurice
   Mutatsa, Stan
   Todd, Gill
   Kolliakou, Anna
   Lally, John
   Stubbs, Brendon
   Ismail, Khalida
   David, Anthony
   Murray, Robin
   Atakan, Zerrin
   Gaughran, Fiona
TI Randomised controlled trial to improve health and reduce substance use
   in established psychosis (IMPaCT): cost-effectiveness of integrated
   psychosocial health promotion
SO BMC PSYCHIATRY
LA English
DT Article
DE Health promotion; Psychosis; Quality of life; Economic; Cost
ID BASE-LINE DATA; CARDIOVASCULAR RISK; METABOLIC SYNDROME;
   DECISION-MAKING; PHYSICAL HEALTH; MENTAL-ILLNESS; WEIGHT-LOSS;
   SELF-REPORT; LIFE-STYLE; PEOPLE
AB Background: There is mounting evidence that people with severe mental illness have unhealthy lifestyles, high rates of cardiovascular and metabolic diseases, and greater risk of early mortality. This study aimed to assess the cost-effectiveness of a health promotion intervention seeking to improve physical health and reduce substance use in people with psychosis.
   Methods: Participants with a psychotic disorder, aged 18-65 years old and registered on an enhanced care approach programme or equivalent were recruited from community mental health teams in six mental health trusts in England. Participants were randomisation to either standard community mental health team care (treatment as usual) or treatment as usual with an integrated health promotion intervention (IMPaCT). Cost-effectiveness and cost-utility analyses from health and social care and societal perspectives were conducted alongside a cluster randomised controlled trial. Total health and social care costs and total societal costs at 12 and 15 months were calculated as well as cost-effectiveness (incremental cost-effectiveness ratios and cost-effectiveness acceptability curves) at 15 months based on quality of life (SF-36 mental and physical health components, primary outcome measures) and quality adjusted life years (QALYs) using two measures, EQ-5D-3 L and SF-36. Data were analysed using bootstrapped regressions with covariates for relevant baseline variables.
   Results: At 12-15 months 301 participants had full data needed to be included in the economic evaluation. There were no differences in adjusted health and social care costs (95 pound, 95% CI -1410 pound to 1599) pound or societal costs (675 pound, 95% CI -1039 pound to 2388) pound between the intervention and control arms. Similarly, there were no differences between the groups in the SF-36 mental component (-0.80, 95% CI -3.66 to 2.06), SF-36 physical component (-0.68, 95% CI -3.01 to 1.65), QALYs estimated from the SF-36 (-0.00, -0.01 to 0.00) or QALYs estimated from the EQ-5D-3 L (0.00, 95% CI -0.01 to 0.02). Cost-effectiveness acceptability curves for all four outcomes and from both cost perspectives indicate that the probability of the health promotion intervention being cost-effective does not exceed 0.4 for willingness to pay thresholds ranging from 0- pound 50,000 pound.
   Conclusions: Alongside no evidence of additional quality of life/clinical benefit, there is also no evidence of cost-effectiveness.
C1 [Heslin, Margaret] Kings Coll London, Inst Psychiat Psychol & Neurosci, Kings Hlth Econ, London, England.
   [Patel, Anita] Queen Mary Univ London, Barts & London Sch Med & Dent, Blizard Inst, Ctr Primary Care & Publ Hlth, Yvonne Carter Bldg,58 Turner St, London E1 2AB, England.
   [Stahl, Daniel; Gardner-Sood, Poonam; Smith, Shubulade; Onagbesan, Oluwadamilola; O'Brien, Conan; Fung, Catherine; Kolliakou, Anna; Lally, John; Ismail, Khalida; David, Anthony; Murray, Robin; Atakan, Zerrin; Gaughran, Fiona] Kings Coll London, Inst Psychiat Psychol & Neurosci, London, England.
   [Mushore, Manyara] London South Bank Univ, London, England.
   [Greenwood, Kathryn] Sussex Partnership NHS Fdn Trust, R&D Dept, Brighton, E Sussex, England.
   [Greenwood, Kathryn] Univ Sussex, Sch Psychol, Brighton, E Sussex, England.
   [Ohlsen, Ruth] Kings Coll London, Florence Nightingale Fac Nursing & Midwifery, London, England.
   [Hopkins, David] Kings Coll Hosp NHS Fdn Trust, Div Ambulatory Care & Local Networks, London, England.
   [Hopkins, David] Kings Coll London, Sch Med, London, England.
   [Lowe, Philippa] Carer Advisor, London, England.
   [Arbuthnot, Maurice] Serv User Advisor, London, England.
   [Mutatsa, Stan] City Univ London, London, England.
   [Todd, Gill] South London & Maudsley NHS Fdn Trust, London, England.
   [Stubbs, Brendon] South London & Maudsley NHS Fdn Trust, Physiotherapy Dept, London, England.
C3 University of London; King's College London; University of London; Queen
   Mary University London; University of London; King's College London;
   London South Bank University; University of Sussex; University of
   London; King's College London; King's College Hospital NHS Foundation
   Trust; University of London; King's College London; City St Georges,
   University of London; City, University of London; South London &
   Maudsley NHS Trust; South London & Maudsley NHS Trust
RP Patel, A (corresponding author), Queen Mary Univ London, Barts & London Sch Med & Dent, Blizard Inst, Ctr Primary Care & Publ Hlth, Yvonne Carter Bldg,58 Turner St, London E1 2AB, England.
EM anitapatelconsulting@gmail.com
RI Gaughran, Fiona/AAC-7160-2019; Hopkins, David/AAP-4541-2020; greenwood,
   kathryn/I-8638-2012; Patel, Anita/F-9832-2010; David,
   Anthony/O-1750-2019; Stubbs, Brendon/X-1904-2018; murray,
   robin/F-8658-2012; Stahl, Daniel/B-9713-2011; Stubbs,
   Brendon/C-5696-2015; Gaughran, Fiona/H-5495-2011; Heslin,
   Margaret/C-4307-2014; David, Anthony/C-1315-2011
OI Hopkins, David/0000-0002-0451-0900; Kolliakou, Anna/0000-0003-1234-4129;
   murray, robin/0000-0003-0829-0519; Ismail, Khalida/0000-0001-6084-449X;
   Stahl, Daniel/0000-0001-7987-6619; Lally, John/0000-0003-3038-0625;
   Patel, Anita/0000-0003-0769-1732; Stubbs, Brendon/0000-0001-7387-3791;
   Gaughran, Fiona/0000-0001-7414-5569; Heslin,
   Margaret/0000-0002-3094-9255; David, Anthony/0000-0003-0967-774X;
   Onagbesan, Okanlawon/0000-0002-9019-8828; Greenwood,
   Kathryn/0000-0001-7899-8980; Smith, Shubulade/0000-0002-3797-6985
FU National Institute for Health Research (NIHR) under its IMPACT Programme
   [RP-PG-0606-1049]; NIHR Collaboration for Leadership in Applied Health
   Research & Care Funding scheme; MRC [G1100583, G0700995, G0600972,
   MR/K013807/1] Funding Source: UKRI
FX This paper summarises independent research funded by the National
   Institute for Health Research (NIHR) under its IMPACT Programme (Grant
   Reference Number RP-PG-0606-1049). FG receives funding from the NIHR
   Collaboration for Leadership in Applied Health Research & Care Funding
   scheme. The views expressed in this publication are those of the
   author(s) and not necessarily those of the NHS, the National Institute
   for Health Research or the Department of Health.
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NR 39
TC 8
Z9 8
U1 0
U2 10
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-244X
J9 BMC PSYCHIATRY
JI BMC Psychiatry
PD DEC 22
PY 2017
VL 17
AR 407
DI 10.1186/s12888-017-1570-1
PG 13
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA FQ9OO
UT WOS:000418691700001
PM 29273021
OA Green Published, gold, Green Accepted
DA 2025-06-11
ER

PT J
AU Di Filippo, C
   Cuzzocrea, S
   Rossi, F
   Marfella, R
   D'Amico, M
AF Di Filippo, Clara
   Cuzzocrea, Salvatore
   Rossi, Francesco
   Marfella, Raffaele
   D'Amico, Michele
TI Oxidative stress as the leading cause of acute myocardial infarction in
   diabetics
SO CARDIOVASCULAR DRUG REVIEWS
LA English
DT Review
DE diabetes; hyperglycemia; inflammation; M40403; myocardial infarction;
   oxidative stress
ID UBIQUITIN-PROTEASOME SYSTEM; SMOOTH-MUSCLE-CELLS; SUPEROXIDE-DISMUTASE;
   HEME OXYGENASE-1; NITRIC-OXIDE; DNA-DAMAGE; POLY(ADP-RIBOSE) POLYMERASE;
   ACUTE HYPERGLYCEMIA; ISCHEMIA-REPERFUSION; ACUTE-INFLAMMATION
AB The risk factors, such as hypertension and metabolic syndrome, tend to promote heart pathology. These risk factors can aggravate concomitant heart insults as well. Diabetes mellitus represents one of the most important risk factors for the development of heart pathology. By itself it represents a source of vascular and heart dysfunction through formation of reactive oxygen species (ROS) and can compromise the recovery from cardiovascular diseases. This review focuses on the evidence that cellular oxidative stress is the leading cause of the worst outcome of myocardial infarction (MI) in diabetics. Hyperglycemia is viewed in this article as the primary mediator of a cascade of heart damaging events, starting from ROS formation and leading to myocardial ischemia, inflammation and death of myocytes. This article also provides insights into why diverse therapeutic interventions, which have in common the ability to reduce oxidative stress and inflammation, can impede or delay the onset of complications of myocardial infarction in diabetic patients.
C1 Univ Naples 2, Dept Expt Med, Naples, Italy.
   Univ Naples 2, Dept Geratr & Metabol Dis, Naples, Italy.
   Univ Naples 2, Excellence Ctr Cardiovasc Dis, Naples, Italy.
   Univ Messina, Dept Clin & Expt Med & Pharmacol, Messina, Italy.
   IRCCS, Ctr Neurolesi Bonino Pulejo, Messina, Italy.
C3 Universita della Campania Vanvitelli; Universita della Campania
   Vanvitelli; Universita della Campania Vanvitelli; University of Messina;
   IRCCS Bonino Pulejo
RP D'Amico, M (corresponding author), Dept Expt Med, Dept Pharmacol, Via Costantinopoli 16, I-80128 Naples, Italy.
EM michele.damico@unina2.it
RI D Amico, Michele/HSH-3483-2023; Cuzzocrea, Salvatore/K-4734-2016;
   Marfella, Raffaele/AAH-2595-2019
OI marfella, raffaele/0000-0003-3960-9270; d'amico,
   michele/0000-0002-6899-0595
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NR 76
TC 84
Z9 90
U1 0
U2 11
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0897-5957
J9 CARDIOVASC DRUG REV
JI Cardiovasc. Drug Rev.
PD SUM
PY 2006
VL 24
IS 2
BP 77
EP 87
PG 11
WC Cardiac & Cardiovascular Systems; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Pharmacology & Pharmacy
GA 080ZZ
UT WOS:000240288300001
PM 16961722
DA 2025-06-11
ER

PT J
AU Li, S
   Fong, DYT
   Wong, JYH
   McPherson, B
   Lau, EYY
   Huang, LX
   Man, IPMS
AF Li, Sha
   Fong, Daniel Yee Tak
   Wong, Janet Yuen Ha
   McPherson, Bradley
   Lau, Esther Yuet Ying
   Huang, Lixi
   Man, I. P. Mary Sau
TI Indoor nocturnal noise is associated with body mass index and blood
   pressure: a cross-sectional study
SO BMC PUBLIC HEALTH
LA English
DT Article
DE Indoor noise; Obesity; Body mass index; Blood pressure
ID ROAD TRAFFIC NOISE; TRANSPORTATION NOISE; HEALTH QUESTIONNAIRE;
   ABDOMINAL ADIPOSITY; OCCUPATIONAL NOISE; METABOLIC SYNDROME; SLEEP
   DURATION; WEIGHT-GAIN; HYPERTENSION; EXPOSURE
AB BackgroundStudies have demonstrated that noise is associated with various health problems, such as obesity and hypertension. Although the evidence of the associations of noise with obesity and hypertension is inconsistent, there seems to be a stronger association of the latter. This study aimed to investigate the associations of noise with body mass index (BMI) and blood pressure in adults living in multi-story residential buildings.MethodsA cross-sectional study was conducted in Hong Kong from February 2018 to September 2019. The Weinstein Noise Sensitivity Scale, Pittsburgh Sleep Quality Index, ENRICHD Social Support Instrument, Patient Health Questionnaire, Perceived Stress Scale, and Hospital Anxiety and Depression Scale were administered to the participants. BMI and blood pressure were assessed. Nocturnal noise exposure and total sleep duration were measured for a week.ResultsFive hundred adults (66.4% female), with an average age of 39years (range: 18-80), completed the study. The average levels of nocturnal noise, BMI, systolic blood pressure (SBP), and diastolic blood pressure (DBP) were 51.3 dBA, 22.2kg/m(2), 116.0mmHg, and 75.4mmHg, respectively. After adjusting for sociodemographic characteristics, nocturnal noise was associated with BMI (b=0.54, 95% CI: 0.01 to 1.06, p=0.045) and SBP (b=2.90, 95% CI: 1.12 to 4.68, p=0.001). No association was detected between nocturnal noise and DBP (b=0.79, 95% CI: -0.56 to 2.13, p=0.253). Specifically, higher nocturnal noise was associated with higher BMI (b=0.72, 95% CI: 0.07 to 1.38, p=0.031) and SBP (b=3.91, 95% CI: 2.51 to 5.31, p<0.001) in females but only higher SBP (b=3.13, 95% CI: 1.35 to 4.92, p<0.001) in males. The association between noise and SBP remained significant (b=2.41, 95% CI: 0.62 to 4.20, p=0.008) after additionally adjusting for lifestyle, diagnosis of hypertension, psychometric constructs, and sleep.ConclusionsIndoor nocturnal noise was associated with BMI and blood pressure in females but only blood pressure in males. It is important to control nocturnal noise or use soundproofing materials in buildings to reduce noise exposure.
C1 [Li, Sha; Fong, Daniel Yee Tak; Wong, Janet Yuen Ha] Univ Hong Kong, Li Ka Shing Fac Med, Sc Nursing, Pokfulam, 21 Sassoon Rd, Hong Kong, Peoples R China.
   [McPherson, Bradley] Univ Hong Kong, Fac Educ, Div Speech & Hearing Sci, Pokfulam, Hong Kong, Peoples R China.
   [Lau, Esther Yuet Ying] Educ Univ Hong Kong, Dept Psychol, Sleep Lab, Tai Po, 10 Lo Ping Rd, Hong Kong, Peoples R China.
   [Lau, Esther Yuet Ying] Educ Univ Hong Kong, Ctr Psychosocial Hlth, Tai Po, 10 Ping Rd, Hong Kong, Peoples R China.
   [Huang, Lixi] Univ Hong Kong, Dept Mech Engn, Pokfulam, Hong Kong, Peoples R China.
   [Man, I. P. Mary Sau] Univ Hong Kong, Li Ka Shing Fac Med, Dept Med, Pokfulam, 21 Sassoon Rd, Hong Kong, Peoples R China.
C3 University of Hong Kong; University of Hong Kong; Education University
   of Hong Kong (EdUHK); Education University of Hong Kong (EdUHK);
   University of Hong Kong; University of Hong Kong
RP Fong, DYT (corresponding author), Univ Hong Kong, Li Ka Shing Fac Med, Sc Nursing, Pokfulam, 21 Sassoon Rd, Hong Kong, Peoples R China.
EM dytfong@hku.hk
RI Wong, Janet/F-4433-2011; Li, Shasha/AAT-3255-2021; Fong,
   Daniel/C-4269-2009
OI Fong, Daniel/0000-0001-7365-9146
FU Health and Medical Research Fund [14150801]; Food and Health Bureau,
   Hong Kong Special Administrative Region
FX This study was supported by the Health and Medical Research Fund [Grant
   No. 14150801], the Food and Health Bureau, Hong Kong Special
   Administrative Region. The funder was not involved in the study's
   design, the collection, analysis, and interpretation of the data, or the
   preparation of the manuscript.
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NR 71
TC 9
Z9 10
U1 0
U2 13
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2458
J9 BMC PUBLIC HEALTH
JI BMC Public Health
PD APR 28
PY 2021
VL 21
IS 1
AR 815
DI 10.1186/s12889-021-10845-2
PG 10
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA RX0GV
UT WOS:000646898700004
PM 33910532
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Gallegos-Carrillo, K
   Garcia-Pena, C
   Salgado-de-Snyder, N
   Salmeron, J
   Lobelo, F
AF Gallegos-Carrillo, Katia
   Garcia-Pena, Carmen
   Salgado-de-Snyder, Nelly
   Salmeron, Jorge
   Lobelo, Felipe
TI Levels of Adherence of an Exercise Referral Scheme in Primary Health
   Care: Effects on Clinical and Anthropometric Variables and Depressive
   Symptoms of Hypertensive Patients
SO FRONTIERS IN PHYSIOLOGY
LA English
DT Article
DE health behaviors; physical activity; hypertension; adherence; primary
   care (MeSH)
ID PHYSICAL-ACTIVITY PROMOTION; RANDOMIZED CONTROLLED-TRIAL; PUBLIC-HEALTH;
   DISEASE; QUESTIONNAIRE; RELIABILITY; PROGRAM
AB Among the modifiable health behaviors, physical activity (PA) promotion has been one of the challenges in primary care, particularly how to translate the results of proven interventions and implement them in the real world. This study was aimed to compare whether two programs designed for hypertensive patients achieve changes in clinical and anthropometric variables, quality of life, and depressive symptoms; and if higher levels of adherence to one of the interventions using an exercise referral (ER) approach achieved better health outcomes. Pragmatic cluster randomized trials were carried out in four Primary Health Care Units (PHCUs). Physicians in the PHCUs identified hypertensive patients and assessed whether they were eligible to be part of this trial. Each center was randomized to a brief PA counseling (BC, n = 2) or an exercise referral (ER, n = 2) intervention to conducted PA programs among hypertensive patients aged 35-70 years, self-reported as physically inactive. Outcome variables included changes in blood pressure levels, triglycerides, HDL cholesterol, fasting glucose, body mass index, waist/hip ratio, abdominal obesity, and metabolic syndrome risk score, health-related quality of life, and depressive symptoms. Longitudinal multilevel analyses assessed the effects of the BC and ER programs and the level of adherence of the ER on clinical, anthropometric, and mental health variables, models were linear for continuous variables, and logistic for dichotomous variables. Differences were observed in triglycerides, BMI, metabolic risk scores variables, and depressive symptoms among ER and BC programs. In addition, differences in the ER group were observed according to the level of adherence in blood pressure levels, waist circumference and waist/hip ratio, depressive symptoms, and the mental health component of health-related quality of life. An ER program in comparison to a BC intervention is promoting changes in some specific health indicators of hypertensive patients, showing the usefulness of these PA programs in primary health care facilities.
C1 [Gallegos-Carrillo, Katia] IMSS, Unidad Invest Epidemiol & Serv Salud, Cuernavaca, Morelos, Mexico.
   [Garcia-Pena, Carmen] Inst Nacl Geriatria, Mexico City, DF, Mexico.
   [Salgado-de-Snyder, Nelly] Inst Nacl Salud Publ Mexico, Ctr Invest Sistemas Salud, Cuernavaca, Morelos, Mexico.
   [Salmeron, Jorge] Univ Nacl Autonoma Mexico, Acad Unit Epidemiol Res, Mexico City, DF, Mexico.
   [Lobelo, Felipe] Emory Univ, Rollins Sch Publ Hlth, Atlanta, GA USA.
C3 Instituto Nacional de Salud Publica; Universidad Nacional Autonoma de
   Mexico; Emory University; Rollins School Public Health
RP Garcia-Pena, C (corresponding author), Inst Nacl Geriatria, Mexico City, DF, Mexico.
EM mcgarciapena@gmail.com
RI García-Peña, Carmen/F-1468-2011; Lobelo, R.L/AAB-2264-2021
FU Secretaria de Educacion, Ciencia, Tecnologia e Innovacion de la Ciudad
   de Mexico [CM-SECTEI/200/2020]; Mexican Social Security Institute,
   Health Research Council (CIS) [FIS/IMSS/PROT/G10/10/841]
FX This project was supported by a grant from the Secretaria de Educacion,
   Ciencia, Tecnologia e Innovacion de la Ciudad de Mexico
   CM-SECTEI/200/2020 "Red colaborativa de Investigacion Traslacional para
   el Envejecimiento Saludable de la Ciudad de Mexico (RECITES)" and also
   by a grant from Mexican Social Security Institute, Health Research
   Council (CIS). FIS/IMSS/PROT/G10/10/841.
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NR 38
TC 2
Z9 4
U1 3
U2 8
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1664-042X
J9 FRONT PHYSIOL
JI Front. Physiol.
PD DEC 21
PY 2021
VL 12
AR 712135
DI 10.3389/fphys.2021.712135
PG 12
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Physiology
GA YB5OI
UT WOS:000739061100001
PM 34992544
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Forgerini, M
   Herdeiro, MT
   Galduróz, JCF
   Mastroianni, PDC
AF Forgerini, Marcela
   Herdeiro, Maria Teresa
   Fernandes Galduroz, Jose Carlos
   Mastroianni, Patricia de Carvalho
TI Risk factors associated with drug therapy among elderly people with
   Alzheimer's disease: a cross-sectional study
SO SAO PAULO MEDICAL JOURNAL
LA English
DT Article
DE Dementia; Patient safety; Polypharmacy
ID POTENTIALLY INAPPROPRIATE MEDICATION; DWELLING OLDER-ADULTS; METABOLIC
   SYNDROME; CONSENSUS PANEL; BEERS CRITERIA; EVENTS; HOSPITALIZATION;
   POLYPHARMACY; COMPLEXITY; MORTALITY
AB BACKGROUND: Improving knowledge and establishing strategies and policies for better patient safety are worldwide priorities.
   OBJECTIVE: To evaluate drug safety among elderly people with Alzheimer's disease (AD).
   DESIGN AND SETTING: Cross-sectional study among elderly people within the National AD Assistance Protocol (PCDTDA/MS) who were living in the municipality of Araraquara, Brazil, in 2017.
   METHODS: Through interviews conducted with relatives/caregivers of elderly people with diagnoses of AD, the following variables were evaluated: comorbidities, drug therapy used, use of potentially inappropriate medications for the elderly (PIMs), presence of potentially inappropriate interactions (PIIs) and medication regimen complexity index. Factors associated with AD severity were also evaluated. Multivariate and simple logistic regressions were applied.
   RESULTS: 143 elderly people enrolled in PCDTDA/MS were analyzed. The majority were women (67.1%); assisted only through the public healthcare system (75.5%); polymedicated (57.4%); using at least one PIM (63.6%); presenting at least one PII (63.6%); and under drug therapy of low to medium complexity (92.2%). No semi-annual monitoring of the effectiveness of PCDTDA/MS drugs was identified. The proportion using AD drug therapy at daily doses differing from those recommended by the World Health Organization was 75.6%. However, these doses were not associated with drug risk.
   CONCLUSION: The data from this study raise the hypothesis that use of polypharmacy might show a correlation with severity of AD. The drug safety risk may be associated with comorbidities of the metabolic syndrome, anxiety and off-label use of PIMs, such as risperidone and quetiapine, and benzodiazepines (i.e. clonazepam and flunitrazepam).
C1 [Forgerini, Marcela] Univ Estadual Paulista UNESP, Sch Pharmaceut Sci, Dept Drugs & Med, Araraquara, SP, Brazil.
   [Herdeiro, Maria Teresa; Fernandes Galduroz, Jose Carlos] Univ Estadual Paulista UNESP, Araraquara, SP, Brazil.
   [Herdeiro, Maria Teresa] Univ Aveiro, Inst Biomed iBiMED, Dept Med Sci, Aveiro, Portugal.
   [Fernandes Galduroz, Jose Carlos] Univ Fed Sao Paulo UNIFESP, Dept Psychobiol, Sao Paulo, SP, Brazil.
   [Mastroianni, Patricia de Carvalho] Univ Estadual Paulista UNESP, Dept Drugs & Med, Araraquara, SP, Brazil.
C3 Universidade Estadual Paulista; Universidade Estadual Paulista;
   Universidade de Aveiro; Universidade Federal de Sao Paulo (UNIFESP);
   Universidade Estadual Paulista
RP Mastroianni, PDC (corresponding author), Univ Estadual Paulista UNESP, Fac Ciencias Farmaceut, Dept Farmacos & Medicamentos, Rodovia Jau,Km 01 S-N, BR-14800901 Araraquara, SP, Brazil.
EM patriciamastroianni@yahoo.com.br
RI Galduróz, José Carlos/G-3305-2012; Mastroianni, Patricia/Y-7107-2019;
   Forgerini, Marcela/AAD-9291-2020; Herdeiro, Maria Teresa/H-8195-2013
OI Herdeiro, Maria Teresa/0000-0002-0500-4049; Forgerini,
   Marcela/0000-0002-2905-8519; Mastroianni, Patricia/0000-0001-8467-7278
FU Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
   [2013/12681-2, 2018/07501-9]; Conselho Nacional de Desenvolvimento
   Tecnologico (CNPq) [459461/2014-1, 131206/2017-6]; Coordenacao de
   Aperfeicoamento de Pessoal de Nivel Superior -Brasil (CAPES) [001];
   Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
   [18/07501-9] Funding Source: FAPESP
FX This work was supported by the Fundacao de Amparo a Pesquisa do Estado
   de Sao Paulo (FAPESP) [grant numbers 2013/12681-2; 2018/07501-9];
   Conselho Nacional de Desenvolvimento Tecnologico (CNPq) [459461/2014-1;
   131206/2017-6] and Coordenacao de Aperfeicoamento de Pessoal de Nivel
   Superior -Brasil (CAPES) -finance code 001
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NR 50
TC 7
Z9 8
U1 2
U2 10
PU ASSOCIACAO PAULISTA MEDICINA
PI SAO PAULO
PA AV BRIG LUIS ANTONIO, 278-7 ANDAR, SAO PAULO, CEP01318-901, BRAZIL
SN 1516-3180
J9 SAO PAULO MED J
JI Sao Paulo Med. J.
PD MAY-JUN
PY 2020
VL 138
IS 3
BP 216
EP 228
DI 10.1590/1516-3180.2019.0461.R2.19022020
PG 13
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA MO7IA
UT WOS:000551693500008
PM 32578741
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Kempf, K
   Martin, S
AF Kempf, Kerstin
   Martin, Stephan
TI Autonomous exercise game use improves metabolic control and quality of
   life in type 2 diabetes patients - a randomized controlled trial
SO BMC ENDOCRINE DISORDERS
LA English
DT Article
DE Type 2 diabetes mellitus; Overweight; Obesity; Exercise game; Lifestyle
   intervention; Non-pharmacological therapy; HbA1c; Weight loss; Quality
   of life
ID VIDEOGAMES; INTERVENTION; MOTIVATION; ADULTS; RISK
AB Background: Lifestyle intervention in type 2 diabetes mellitus (T2DM) is effective but needs a special local setting and is costly. Therefore, in a randomized-controlled trial we tested the hypothesis that the autonomous use of the interactive exercise game Wii Fit Plus over a period of 12 weeks improves metabolic control, with HbA1c reduction as the primary outcome, and weight loss, reduction of cardiometabolic risk factors, physical activity and quality of life (secondary outcomes) in T2DM patients.
   Methods: Participants (n = 220) were randomized into an intervention and a control group. The intervention group was provided with a Wii console, a balance board and the exercise game Wii Fit Plus for 12 weeks. The control group remained under routine care and received the items 12 weeks later. At baseline and after 12 weeks (and for the control group additionally after 12 weeks of intervention) the participants' health parameters, medication, physical activity and validated questionnaires for quality of life (PAID, SF12, WHO-5, CES-D) were requested and compared in a complete case analysis using the Mann-Whitney test and the Wilcoxon signed rank test.
   Results: 80% of participants completed the 12-week study. Patients in the intervention group significantly improved HbA1c (from 7.1 +/- 1.3% to 6.8 +/- 0.9%; -0.3 +/- 1.1%; p = 0.0002) in comparison to the control group (from 6.8 +/- 0.9% to 6.7 +/- 0.7%; -0.1 +/- 0.5%) and also significantly reduced fasting blood glucose (from 135.8 +/- 38.9 mg/dl to 126.6 +/- 36.6 mg/dl; p = 0.04), weight (from 97.6 +/- 19.2 kg to 96.3 +/- 18.7 kg; p < 0.001) and body mass index (from 34.1 +/- 6.5 kg/m(2) to 33.5 +/- 6.5 kg/m(2); p < 0.001). Daily physical activity increased significantly (p < 0.001). Diabetes-dependent impairment, mental health, subjective wellbeing and quality of life also improved significantly, and the number of patients with depression decreased. Similar improvements were seen in the control group after exercise game intervention.
   Conclusions: In this trial a low-threshold intervention with the interactive exercise game Wii Fit Plus was able to motivate T2DM patients to improve physical activity, glucometabolic control and quality of life.
C1 [Kempf, Kerstin; Martin, Stephan] West German Ctr Diabet & Hlth, Dusseldorf Catholic Hosp Grp, D-40591 Dusseldorf, Germany.
RP Kempf, K (corresponding author), West German Ctr Diabet & Hlth, Dusseldorf Catholic Hosp Grp, Hohensandweg 37, D-40591 Dusseldorf, Germany.
EM kerstin.kempf@wdgz.de
FU Novartis Pharma GmbH; foundation 'Motivation zur Lebensstil-Anderung -
   Chance bei Diabetes Stiftung in der Deutschen Diabetes Stiftung'
FX The study was funded by Novartis Pharma GmbH and supported by the
   foundation 'Motivation zur Lebensstil-Anderung - Chance bei Diabetes
   Stiftung in der Deutschen Diabetes Stiftung'. We thank our study nurse
   B. Arnold for her excellent work.
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NR 22
TC 71
Z9 75
U1 1
U2 26
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1472-6823
J9 BMC ENDOCR DISORD
JI BMC Endocr. Disord.
PD DEC 10
PY 2013
VL 13
AR 57
DI 10.1186/1472-6823-13-57
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 293AH
UT WOS:000329943300001
PM 24321337
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Sentissi, O
   Zosso, G
   Cogordon, A
   Chillà, C
AF Sentissi, Othman
   Zosso, Gabrielle
   Cogordon, Anouck
   Chilla, Chiara
TI The effects of a group-based intervention through physical activities
   and dietary changes in young patients with severe psychiatric disorders:
   a pilot study
SO FRONTIERS IN SPORTS AND ACTIVE LIVING
LA English
DT Article
DE physical activity program; exercises; dietary program; eating behaviour;
   mental disorders; weight gain; metabolic disturbances
ID MAJOR DEPRESSIVE DISORDER; EUROFIT TEST BATTERY; METABOLIC SYNDROME;
   MENTAL-HEALTH; CARDIORESPIRATORY FITNESS; SEDENTARY BEHAVIOR; BIPOLAR
   DISORDER; AEROBIC EXERCISE; WEIGHT-GAIN; SCHIZOPHRENIA
AB Background and objectives: The present study aims to investigate the effect of the 4-F (Fit, Fun, Feel, and Food) group-based program on physical, clinical, and biological outcomes in young patients suffering from severe psychiatric disorders.
   Methods: A pilot study with a naturalistic design was conducted to investigate the effect of a group-based intervention on young patients.
   Results: A descriptive analysis revealed that out of the 61 outpatients initially enrolled in the program, with a mean age of 26.9 years old (+/- 6.1, 60% men), 71% were overweight or obese. Paired T-tests for the difference between T0 and T1 were used to evaluate the evolution of the outcomes. The 24 patients who completed the full program showed no significant decrease in weight or body composition. Despite the limitations, the main findings of this study were the significant improvement in muscular endurance and coordination (from T0 (M= 13.65, SD = +/- 1.93) compared to T1 (M= 12.49, SD = +/- 1.81), [t(20) = 3.072, p < 0.05] and the general increase in mental well-being from baseline to the end of the program according to the type of psychopathology [F(3,10) = 4.25, p <.05]. A slight modification in eating behavior, with a tendency towards a decrease in TFEQ hunger levels, was also noticed. The ANCOVA showed no difference in outcomes between the groups based on diagnosis.
   Conclusion: Despite its limitations and the small sample size, this pilot study provides valuable insights, demonstrating the feasibility of the program and its positive impact on physical well-being and improved mental health in young patients with psychiatric disorders, sedentary behavior, and unhealthy lifestyles. These encouraging results warrant further research in controlled, larger population samples to deepen our understanding of the potential effects of such interventions.
C1 [Sentissi, Othman; Zosso, Gabrielle; Cogordon, Anouck; Chilla, Chiara] Univ Hosp Geneva, Ambulatory Psychiat Ctr Cappi Jonct, Adult Psychiat Div, Geneva, Switzerland.
   [Sentissi, Othman] Univ Geneva, Fac Med, Dept Psychiat, Geneva, Switzerland.
C3 University of Geneva; University of Geneva
RP Sentissi, O (corresponding author), Univ Hosp Geneva, Ambulatory Psychiat Ctr Cappi Jonct, Adult Psychiat Div, Geneva, Switzerland.; Sentissi, O (corresponding author), Univ Geneva, Fac Med, Dept Psychiat, Geneva, Switzerland.
EM o.sentissi@hcuge.ch
RI Sentissi, Othman/AAS-9239-2021
FU This pilot study is part of a clinical and research program
   investigating WG and sedentary inpatients suffering from psychiatric
   disorders, funded by the Foundation priv des HUG (University Hospitals
   of Geneva) and with a sponsorship grant from Sun; Foundation priv des
   HUG (University Hospitals of Geneva); Sunovion; University of Geneva
FX This pilot study is part of a clinical and research program
   investigating WG and sedentary inpatients suffering from psychiatric
   disorders, funded by the Foundation prive des HUG (University Hospitals
   of Geneva) and with a sponsorship grant from Sunovion. Open access
   funding by University of Geneva.r This pilot study is part of a clinical
   and research program investigating WG and sedentary inpatients suffering
   from psychiatric disorders, funded by the Foundation prive des HUG
   (University Hospitals of Geneva) and with a sponsorship grant from
   Sunovion. Open access funding by University of Geneva.
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NR 69
TC 0
Z9 0
U1 0
U2 5
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 2624-9367
J9 FRONT SPORTS ACT LIV
JI Front. Sports Act. Living
PD AUG 22
PY 2023
VL 5
AR 1197925
DI 10.3389/fspor.2023.1197925
PG 12
WC Sport Sciences
WE Emerging Sources Citation Index (ESCI)
SC Sport Sciences
GA R1QH8
UT WOS:001062152600001
PM 37674637
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Helget, LN
   England, BR
   Roul, P
   Sayles, H
   Petro, AD
   Neogi, T
   O'Dell, JR
   Mikuls, TR
AF Helget, Lindsay N.
   England, Bryant R.
   Roul, Punyasha
   Sayles, Harlan
   Petro, Alison D.
   Neogi, Tuhina
   O'Dell, James R.
   Mikuls, Ted R.
TI Cause-Specific Mortality in Patients With Gout in the US Veterans Health
   Administration: A Matched Cohort Study
SO ARTHRITIS CARE & RESEARCH
LA English
DT Article
ID SERUM URIC-ACID; CHRONIC KIDNEY-DISEASE; CARDIOVASCULAR MORTALITY;
   METABOLIC SYNDROME; BLOOD-PRESSURE; HYPERURICEMIA; PREVALENCE; RISK;
   ASSOCIATION; INCREASES
AB Objective To compare all-cause and cause-specific mortality risk between patients with gout and patients without gout in the Veteran's Health Administration (VHA). Methods We performed a matched cohort study, identifying patients with gout in the VHA from January 1999 to September 2015 based on the presence of >= 2 International Classification of Diseases, Ninth Revision codes for gout (274.X). Gout patients were matched up to 1:10 on birth year, sex, and year of VHA enrollment with patients without gout and followed until death or end of study (December 2017). Cause of death was obtained from the National Death Index. Associations of gout with all-cause and cause-specific mortality were examined using multivariable Cox regression. Results Gout (n = 559,243) and matched non-gout controls (n = 5,428,760) had a mean age of 67 years and were 99% male. There were 246,291 deaths over 4,250,371 patient-years in gout patients and 2,000,000 deaths over 40,441,353 patient-years of follow-up in controls. After matching, gout patients had an increased risk of death (hazard ratio [HR] 1.09 [95% confidence interval (95% CI) 1.08-1.09]), which was no longer present after adjusting for comorbidities (HR 0.98 [95% CI 0.97-0.98]). The strongest association of gout with cause-specific mortality was observed with genitourinary conditions (HR 1.50 [95% CI 1.47-1.54]). Gout patients were at lower risk of death related to neurologic (e.g., Alzheimer's disease and Parkinson's disease) (HR 0.63 [95% CI 0.62-0.65]) and mental health (HR 0.66 [95% CI 0.65-0.68]) conditions. Conclusion A higher risk of death among gout patients in the VHA was related to comorbidity burden. While deaths attributable to neurologic and mental health conditions were less frequent among gout patients, genitourinary conditions were the most overrepresented causes of death.
C1 [Helget, Lindsay N.; England, Bryant R.; Roul, Punyasha; Petro, Alison D.; O'Dell, James R.; Mikuls, Ted R.] Vet Affairs NebraskaWestern Iowa Hlth Care Syst, Omaha, NE 68105 USA.
   [Helget, Lindsay N.; England, Bryant R.; Roul, Punyasha; Sayles, Harlan; Petro, Alison D.; O'Dell, James R.; Mikuls, Ted R.] Univ Nebraska Med Ctr, Omaha, NE 68198 USA.
   [Neogi, Tuhina] Boston Univ, Sch Med, Boston, MA 02118 USA.
C3 University of Nebraska System; University of Nebraska Medical Center;
   Boston University
RP Mikuls, TR (corresponding author), Vet Affairs NebraskaWestern Iowa Hlth Care Syst, Omaha, NE 68105 USA.; Mikuls, TR (corresponding author), Univ Nebraska Med Ctr, Omaha, NE 68198 USA.
EM tmikuls@unmc.edu
RI England, Bryant/AAH-6545-2020; Neogi, Tuhina/AAM-1110-2020; ,
   Punyasha/HJO-8788-2023
OI Helget, Lindsay/0000-0001-7716-209X; England, Bryant
   R./0000-0002-9649-3588; Neogi, Tuhina/0000-0002-9515-1711; ,
   Punyasha/0000-0001-6035-700X; Mikuls, Ted/0000-0002-0897-2272
FU Horizon Therapeutics; Rheumatology Research Foundation; NIH
   [U54-GM-115458, K24-AR-070892]; Department of Veterans Affairs
   [BX004600, IK2CX002203]
FX Supported by Horizon Therapeutics (unrestricted grant). Dr. England's
   work was supported by the Department of Veterans Affairs (Clinical
   Science Research and Development grant IK2CX002203) and the Rheumatology
   Research Foundation. Dr. Neogi's work was supported by the NIH (grant
   K24-AR-070892). Dr. Mikuls' work was supported by the Department of
   Veterans Affairs (grant BX004600) and the NIH (grant U54-GM-115458).
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NR 50
TC 6
Z9 6
U1 0
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2151-464X
EI 2151-4658
J9 ARTHRIT CARE RES
JI Arthritis Care Res.
PD APR
PY 2023
VL 75
IS 4
BP 808
EP 816
DI 10.1002/acr.24881
EA NOV 2022
PG 9
WC Rheumatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Rheumatology
GA C1DQ7
UT WOS:000881720500001
PM 35294114
OA hybrid, Green Accepted
DA 2025-06-11
ER

PT J
AU Szczepanska-Sadowska, E
   Cudnoch-Jedrzejewska, A
   Ufnal, M
   Zera, T
AF Szczepanska-Sadowska, E.
   Cudnoch-Jedrzejewska, A.
   Ufnal, M.
   Zera, T.
TI BRAIN AND CARDIOVASCULAR DISEASES: COMMON NEUROGENIC BACKGROUND OF
   CARDIOVASCULAR, METABOLIC AND INFLAMMATORY DISEASES
SO JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
LA English
DT Review
DE angiotensin; apelin; cardiovascular diseases; cytokines;
   endocannabinoids; gasotransmitters; neuropeptides; orexin; vasopressin
ID TUMOR-NECROSIS-FACTOR; ROSTRAL VENTROLATERAL MEDULLA; CENTRALLY
   ADMINISTERED INTERLEUKIN-1-BETA; HYPOTHALAMIC PARAVENTRICULAR NUCLEUS;
   PROINFLAMMATORY CYTOKINE RESPONSE; CENTRAL VASOPRESSINERGIC SYSTEM;
   SYMPATHETIC-NERVE ACTIVITY; MEDIAL PREFRONTAL CORTEX; RENIN-ANGIOTENSIN
   SYSTEM; CENTRAL PRESSOR ACTION
AB In spite of significant progress in pharmacotherapy the incidence of newly diagnosed cases of cardiovascular diseases and cardiovascular morbidity is alarmingly high. Treatment of hypertension or heart failure still remains a serious challenge. Continuous attempts are made to identify the mechanisms that decide about susceptibility to pathogenic factors, and to determine effectiveness of a specific therapeutic approach. Coincidence of cardiovascular diseases with metabolic disorders and obesity has initiated intensive research for their common background. In the recent years increasing attention has been drawn to disproportionately greater number of depressive disorders and susceptibility to stress in patients with coronary artery disease. An opposite relationship, i.e. a greater number of sudden cardiovascular complications in patients with depression, has been also postulated. Progress in functional neuroanatomy and neurochemistry provided new information about the neural network responsible for regulation of cardiovascular functions, metabolism and emotionality in health and under pathological conditions. In this review we will focus on the role of neuromodulators and neurotransmitters engaged in regulation of the cardiovascular system, neuroendocrine and metabolic functions in health and in pathogenesis of cardiovascular diseases and obesity. Among them are classical neurotransmitters (epinephrine and norepinephrine, serotonin, GABA), classical (CRH, vasopressin, neuropeptide Y) and newly discovered (orexins, apelin, leptin IL-I beta, TNF-alpha, ghrelin) neuropeptides, gasotransmitters, eicozanoids, endocannabinoids, and some other compounds involved in regulation of neuroendocrine, sympatho-adrenal and parasympathetic nervous systems. Special attention is drawn to those factors which play a role in immunology and inflammatory processes. Interaction between various neurotransmitter/neuromodulatory systems which may be involved in integration of metabolic and cardiovascular functions is analyzed. The survey gives evidence for significant disturbances in release or action of the same mediators in hypertension heart failure, obesity, diabetes mellitus, metabolic syndrome, starvation, chronic stress, depression and other psychiatric disorders. With regard to the pathogenic background of the cardiovascular diseases especially valuable are the studies showing inappropriate function of angiotensin peptides, vasopressin, CRH, apelin, cytokines and orexins in chronic stress, cardiovascular and metabolic diseases. The studies surveyed in this review suggest that multiple brain mechanisms interact together sharing the same neural circuits responsible for adjustment of function of the cardiovascular system and metabolism to current needs.
C1 [Szczepanska-Sadowska, E.; Cudnoch-Jedrzejewska, A.; Ufnal, M.; Zera, T.] Med Univ Warsaw, Dept Expt & Clin Physiol, PL-00924 Warsaw, Poland.
C3 Medical University of Warsaw
RP Szczepanska-Sadowska, E (corresponding author), Med Univ Warsaw, Dept Expt & Clin Physiol, 26-28 Krakowskie Przedmiescie St, PL-00924 Warsaw, Poland.
EM eszczepanska@wum.edu.pl
RI Cudnoch-Jedrzejewska, Agnieszka/AAU-8663-2020; Szczepanska-Sadowska,
   Ewa/AGQ-9776-2022; Ufnal, Marcin/I-6868-2019; Zera,
   Tymoteusz/Y-7586-2018; Cudnoch-Jedrzejewska, Agnieszka/M-3642-2018
OI Zera, Tymoteusz/0000-0003-3535-715X; Ufnal, Marcin/0000-0003-0088-8284;
   Cudnoch-Jedrzejewska, Agnieszka/0000-0002-1605-4447;
   Szczepanska-Sadowska, Ewa/0000-0002-3761-508X
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NR 207
TC 105
Z9 114
U1 0
U2 26
PU POLISH PHYSIOLOGICAL SOC
PI GRZEGORZECKA
PA JAGIELLONIAN UNIV SCHOOL MED, INST PHYSIOLOGY, 31-531 KRAKOW, 16
   GRZEGORZECKA, POLAND
SN 0867-5910
J9 J PHYSIOL PHARMACOL
JI J. Physiol. Pharmacol.
PD OCT
PY 2010
VL 61
IS 5
BP 509
EP 521
PG 13
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA 687PN
UT WOS:000284790500001
PM 21081794
DA 2025-06-11
ER

PT J
AU Dastghaib, S
   Kumar, PS
   Aftabi, S
   Damera, G
   Dalvand, A
   Sepanjnia, A
   Kiumarsi, M
   Aghanoori, MR
   Sohal, SS
   Ande, SR
   Alizadeh, J
   Mokarram, P
   Ghavami, S
   Sharma, P
   Zeki, AA
AF Dastghaib, Sanaz
   Kumar, P. Sravan
   Aftabi, Sajjad
   Damera, Gautam
   Dalvand, Azadeh
   Sepanjnia, Adel
   Kiumarsi, Mohammad
   Aghanoori, Mohamad-Reza
   Sohal, Sukhwinder Singh
   Ande, Sudharsana R.
   Alizadeh, Javad
   Mokarram, Pooneh
   Ghavami, Saeid
   Sharma, Pawan
   Zeki, Amir A.
TI Mechanisms Targeting the Unfolded Protein Response in Asthma
SO AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
LA English
DT Review
DE endoplasmic reticulum; endoplasmic reticulum stress; asthma; unfolded
   protein response
ID ENDOPLASMIC-RETICULUM STRESS; ER STRESS; CELL-DEATH; ORMDL3 GENE;
   AUTOPHAGY; INFLAMMATION; APOPTOSIS; UPR; EXPRESSION; SENSOR
AB Lung cells are constantly exposed to various internal and external stressors that disrupt protein homeostasis. To cope with these stimuli, cells evoke a highly conserved adaptive mechanism called the unfolded protein response (UPR). UPR stressors can impose greater protein secretory demands on the endoplasmic reticulum (ER), resulting in the development, differentiation, and survival of these cell types to meet these increasing functional needs. Dysregulation of the UPR leads to the development of the disease. The UPR and ER stress are involved in several human conditions, such as chronic inflammation, neurodegeneration, metabolic syndrome, and cancer. Furthermore, potent and specific compounds that target the UPR pathway are under development as future therapies. The focus of this review is to thoroughly describe the effects of both internal and external stressors on the ER in asthma. Furthermore, we discuss how the UPR signaling pathway is activated in the lungs to overcome cellular damage. We also present an overview of the pathogenic mechanisms, with a brief focus on potential strategies for pharmacological interventions.
C1 [Dastghaib, Sanaz; Mokarram, Pooneh] Shiraz Univ Med Sci, Dept Clin Biochem, Shiraz, Iran.
   [Aghanoori, Mohamad-Reza] Shiraz Univ Med Sci, Dept Human Genet, Sch Med, Shiraz, Iran.
   [Dastghaib, Sanaz; Mokarram, Pooneh; Ghavami, Saeid] Shiraz Univ Med Sci, Autophagy Res Ctr, Hlth Policy Res Ctr, Inst Hlth, Shiraz, Iran.
   [Kumar, P. Sravan] Natl Inst Pharmaceut Educ & Res, Hyderabad, Telangana, India.
   [Aftabi, Sajjad; Dalvand, Azadeh; Kiumarsi, Mohammad; Alizadeh, Javad; Ghavami, Saeid] Univ Manitoba, Rady Fac Hlth Sci, Dept Human Anat & Cell Sci, Max Rady Coll Med,Children Hosp Res Inst Manitoba, Winnipeg, MB, Canada.
   [Aghanoori, Mohamad-Reza] Univ Manitoba, Dept Pharmacol & Therapeut, Children Hosp Res Inst Manitoba, Winnipeg, MB, Canada.
   [Ande, Sudharsana R.; Ghavami, Saeid] Univ Manitoba, Dept Internal Med, Children Hosp Res Inst Manitoba, Winnipeg, MB, Canada.
   [Ghavami, Saeid] Univ Manitoba, Biol Breathing Theme, Children Hosp Res Inst Manitoba, Winnipeg, MB, Canada.
   [Aftabi, Sajjad] Univ Manitoba, Med Phys Dept, Canc Care Manitoba, Winnipeg, MB, Canada.
   [Alizadeh, Javad] Univ Manitoba, Res Inst Oncol & Hematol, Canc Care Manitoba, Winnipeg, MB, Canada.
   [Damera, Gautam] Teva Pharmaceut, Global Res & Dev, Personalized & Predict Med Resp, Malvern, PA USA.
   [Sepanjnia, Adel] Jiroft Univ Med Sci, Sch Med, Dept Immunol, Jiroft, Iran.
   [Aghanoori, Mohamad-Reza] St Boniface Gen Hosp, Div Neurodegenerat Disorders, Albrechtsen Res Ctr, Winnipeg, MB, Canada.
   [Sohal, Sukhwinder Singh] Univ Tasmania, Coll Hlth & Med, Dept Lab Med, Resp Translat Res Grp, Launceston, Tas, Australia.
   [Sharma, Pawan] Thomas Jefferson Univ, Ctr Translat Med, Philadelphia, PA 19107 USA.
   [Zeki, Amir A.] Univ Calif Davis, Lung Ctr, Div Pulm Crit Care & Sleep Med, Dept Internal Med,Sch Med, Davis, CA 95616 USA.
   [Zeki, Amir A.] Vet Affairs Med Ctr, Mather, CA USA.
C3 Shiraz University of Medical Science; Shiraz University of Medical
   Science; Shiraz University of Medical Science; National Institute of
   Pharmaceutical Education & Research, Hyderabad; National Institute of
   Pharmaceutical Education & Research, S.A.S. Nagar (Mohali); University
   of Manitoba; Children's Hospital Research Institute of Manitoba;
   University of Manitoba; Children's Hospital Research Institute of
   Manitoba; University of Manitoba; Children's Hospital Research Institute
   of Manitoba; University of Manitoba; Children's Hospital Research
   Institute of Manitoba; University of Manitoba; CancerCare Manitoba
   Foundation; University of Manitoba; CancerCare Manitoba Foundation; Teva
   Pharmaceutical Industries; Teva Pharmaceutical Industries USA;
   University of Manitoba; Children's Hospital Research Institute of
   Manitoba; Saint Boniface Hospital; University of Tasmania; Thomas
   Jefferson University; University of California System; University of
   California Davis; US Department of Veterans Affairs; Veterans Health
   Administration (VHA)
RP Zeki, AA (corresponding author), Univ Calif Davis, Davis Genome & Biomed Sci Facil, 451 Hlth Sci Dr Room 6517, Davis, CA 95616 USA.
EM aazeki@ucdavis.edu
RI Aghanoori, Mohamad-Reza/AAC-8164-2021; Alizadeh, Javad/AAR-4824-2020;
   Sohal, Sukhwinder/J-7395-2014; Zeki, Amir/I-3930-2019; Ghavami,
   Saeid/Q-8918-2016; Ande, Sudharsana Rao/AAU-6950-2021; Dastghaib,
   Sanaz/ABD-5899-2021; Mokarram, Pooneh/E-1613-2012; Sepanjnia,
   Adel/G-1163-2017; Sharma, Pawan/D-4314-2016
OI Dastghaib, Sanaz/0000-0001-8553-9221; Sharma, Pawan/0000-0002-2904-2306;
   Ande, Sudharsana Rao/0000-0001-8194-2902; Sohal, Sukhwinder
   Singh/0000-0001-9627-6498; Aghanoori, Mohamad-Reza/0000-0003-1495-748X;
   Ghavami, Saeid/0000-0001-5948-508X
FU University of California, Davis, Principal Investigator Bridge Fund;
   Rebecca Cooper Research Foundation; Research Manitoba New Investigator
   Operating grant
FX Supported by University of California, Davis, Principal Investigator
   Bridge Fund (A.A.Z.), the Rebecca Cooper Research Foundation (P.S. and
   S.S.S.), and a Research Manitoba New Investigator Operating grant
   (S.G.).
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NR 117
TC 29
Z9 30
U1 0
U2 13
PU AMER THORACIC SOC
PI NEW YORK
PA 25 BROADWAY, 18 FL, NEW YORK, NY 10004 USA
SN 1044-1549
EI 1535-4989
J9 AM J RESP CELL MOL
JI Am. J. Respir. Cell Mol. Biol.
PD JAN
PY 2021
VL 64
IS 1
BP 29
EP 38
DI 10.1165/rcmb.2019-0235TR
PG 10
WC Biochemistry & Molecular Biology; Cell Biology; Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology; Respiratory System
GA PO5SS
UT WOS:000605229700009
PM 32915643
OA Green Published
DA 2025-06-11
ER

PT J
AU Rajasingam, D
   Seed, PT
   Briley, AL
   Shennan, AH
   Poston, L
AF Rajasingam, Daghni
   Seed, Paul T.
   Briley, Annette L.
   Shennan, Andrew H.
   Poston, Lucilla
TI A prospective study of pregnancy outcome and biomarkers of oxidative
   stress in nulliparous obese women
SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
LA English
DT Article; Proceedings Paper
CT 54th Annual Meeting of the Society-for-Gynecologic-Investigation
CY MAR 14-17, 2007
CL Reno, NV
SP Soc Gynecol Invest
DE obesity; oxidative stress; preeclampsia; small for gestational age
ID SERUM URIC-ACID; BODY-MASS INDEX; PERFORMANCE LIQUID-CHROMATOGRAPHY;
   MATERNAL OBESITY; RISK-FACTORS; METABOLIC SYNDROME; VITAMIN-E;
   PREECLAMPSIA; OVERWEIGHT; WEIGHT
AB OBJECTIVE: We sought to investigate pregnancy outcome and biomarkers of oxidative stress in nulliparous obese pregnant women.
   STUDY DESIGN: Pregnancy outcome and blood biomarkers were assessed prospectively in 385 obese nulliparous women from the placebo arm of a randomized controlled trial.
   RESULTS: Body mass index was associated with higher rates of preeclampsia (PE) (P = .010) and cesarean section (P = .016). In all, 18.8% of infants were small for gestational age (< 10th adjusted birthweight centile), 13.4% were large for gestational age (> 90th centile), and 11.9% were preterm. The plasma ascorbic acid concentration was inversely related to small-for-gestational-age delivery (P < .025), and increased plasma triglyceride concentrations with later PE (P < .0001). Plasma uric acid concentration (P = .043) and the gamma- tocopherol: alpha-tocopherol ratio (P = .023) were related to body mass index.
   CONCLUSION: A previously unreported risk of fetal growth restriction associated with reduced plasma ascorbic acid concentration was identified in nulliparous obese women. The high incidence of PE and preterm birth were unrelated to oxidative stress markers.
C1 [Rajasingam, Daghni; Seed, Paul T.; Briley, Annette L.; Shennan, Andrew H.; Poston, Lucilla] Kings Coll London, Maternal & Fetal Res Unit, Div Reprod & Endocrinol, London SE1 7EH, England.
C3 University of London; King's College London
RP Poston, L (corresponding author), Kings Coll London, St Thomas Hosp, Maternal & Fetal Res Unit, Div Reprod & Endocrinol, 10th Floor N Wing,Westminster Bridge Rd, London SE1 7EH, England.
EM lucilla.poston@kcl.ac.uk
RI Briley, Annette/N-1704-2019; Seed, Paul T/C-4435-2008
OI Briley, Annette/0000-0002-4266-920X; Shennan,
   Andrew/0000-0001-5273-3132; Seed, Paul T/0000-0001-7904-7933
FU Wellcome Trust [069056/Z/02/Z] Funding Source: Medline
CR [Anonymous], 2007, TACKL OB FUT CHOIC P
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NR 47
TC 88
Z9 95
U1 0
U2 9
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0002-9378
EI 1097-6868
J9 AM J OBSTET GYNECOL
JI Am. J. Obstet. Gynecol.
PD APR
PY 2009
VL 200
IS 4
AR 395.e1
DI 10.1016/j.ajog.2008.10.047
PG 9
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Obstetrics & Gynecology
GA 422BX
UT WOS:000264403100016
PM 19200933
DA 2025-06-11
ER

PT J
AU Liang, E
   Ma, M
   Wang, L
   Liu, X
   Xu, JF
   Zhang, MX
   Yang, RX
   Zhao, YX
AF Liang, Ershun
   Ma, Min
   Wang, Lei
   Liu, Xue
   Xu, Jinfeng
   Zhang, Mingxiang
   Yang, Ruixue
   Zhao, Yuxia
TI The BET/BRD inhibitor JQ1 attenuates diabetes-induced cognitive
   impairment in rats by targeting Nox4-Nrf2 redox imbalance
SO BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
LA English
DT Article
DE Diabetes; Cognitive dysfunction; Oxidative stress; Nox4; Nrf2
ID OXIDATIVE STRESS; INSULIN-RESISTANCE; METABOLIC SYNDROME; BRAIN;
   INFLAMMATION; EXPRESSION; PATHWAY; DAMAGE; NOX4; PHOSPHORYLATION
AB Diabetes-induced oxidative damage is believed to play an important role in the development of cognitive dysfunction. In this study, the involvement of the Nox4-Nrf2 redox imbalance was investigated. STZ-induced diabetic rats exhibited obvious oxidative stress and apoptosis in the hippocampus assessed by augmentation of lipid peroxidation, positive TUNEL staining, elevated ratio of Bax/Bcl-2 and increased caspase 3 activity. Furthermore, hyperglycemia markedly increased Nox4 activity and reduced the activation of Nrf2 by suppressing its up-stream regulatory Akt as well as down-stream target HO-1. Significant improvement of cognitive performance was observed after treatment with the BET/BRD inhibitor JQ1, accompanied by decreased oxidative stress, neuroinflammation and apoptosis in the hippocampus. JQ1 treatment also improved changes in the neuronal cell morphology as well as increased the expression of p-AKT, Nrf2 and HO-1. Our results provide evidence indicating that JQ1 treatment could modulate Nox4-Nrf2 redox imbalance in the hippocampus and may be a promising agent for diabetes associated cognitive dysfunction. (C) 2017 Elsevier Inc. All rights reserved.
C1 [Liang, Ershun; Liu, Xue; Zhang, Mingxiang; Yang, Ruixue; Zhao, Yuxia] Shandong Univ, Qilu Hosp, Dept Cardiol, Key Lab Cardiovasc Remodeling & Funct Res, Jinan 250012, Shandong, Peoples R China.
   [Liang, Ershun; Liu, Xue; Zhang, Mingxiang; Yang, Ruixue; Zhao, Yuxia] Shandong Univ, Qilu Hosp, Dept Cardiol, State & Shandong Prov Joint Key Lab Translat Card, Jinan 250012, Shandong, Peoples R China.
   [Ma, Min] Third Hosp Jinan, Dept Oncol, Jinan 250132, Shandong, Peoples R China.
   [Wang, Lei] Jining 1 Peoples Hosp, Dept Urol, Jining 272011, Shandong, Peoples R China.
   [Xu, Jinfeng] Jinan Univ, Shenzhen Peoples Hosp, Clin Coll 2, Dept Ultrasonog, Shenzhen 518020, Peoples R China.
C3 Shandong University; Shandong University; Jinan University
RP Zhang, MX; Yang, RX (corresponding author), Shandong Univ, Qilu Hosp, Dept Cardiol, Key Lab Cardiovasc Remodeling & Funct Res, Jinan 250012, Shandong, Peoples R China.; Zhang, MX; Yang, RX (corresponding author), Shandong Univ, Qilu Hosp, Dept Cardiol, State & Shandong Prov Joint Key Lab Translat Card, Jinan 250012, Shandong, Peoples R China.
EM zhangmingxiangsd@163.com; yangruixueql@126.com
RI ma, min/IWV-2792-2023; xu, Linlin/JCF-2403-2023; Zhang,
   Yunjiao/AAG-4482-2020
FU National 973 Basic Research Program of China [2012CB518603]; National
   Natural Science Foundation of China [81302939, 81771841]
FX This study was supported by the National 973 Basic Research Program of
   China (No. 2012CB518603), and the National Natural Science Foundation of
   China (No. 81302939, No. 81771841).
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TC 25
Z9 25
U1 2
U2 17
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0006-291X
EI 1090-2104
J9 BIOCHEM BIOPH RES CO
JI Biochem. Biophys. Res. Commun.
PD JAN 1
PY 2018
VL 495
IS 1
BP 204
EP 211
DI 10.1016/j.bbrc.2017.11.020
PG 8
WC Biochemistry & Molecular Biology; Biophysics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics
GA FU5MM
UT WOS:000423897600033
PM 29113796
DA 2025-06-11
ER

PT J
AU Hayakawa, S
   Ohashi, K
   Shibata, R
   Takahashi, R
   Otaka, N
   Ogawa, H
   Ito, M
   Kanemura, N
   Hiramatsu-Ito, M
   Ikeda, N
   Murohara, T
   Ouchi, N
AF Hayakawa, Satoko
   Ohashi, Koji
   Shibata, Rei
   Takahashi, Ryotaro
   Otaka, Naoya
   Ogawa, Hayato
   Ito, Masanori
   Kanemura, Noriyoshi
   Hiramatsu-Ito, Mizuho
   Ikeda, Nobuo
   Murohara, Toyoaki
   Ouchi, Noriyuki
TI Association of Circulating Follistatin-Like 1 Levels with Inflammatory
   and Oxidative Stress Markers in Healthy Men
SO PLOS ONE
LA English
DT Article
ID C-REACTIVE PROTEIN; CHRONIC KIDNEY-DISEASE; CARDIOVASCULAR-DISEASE;
   PROMOTES ARTHRITIS; METABOLIC SYNDROME; HEART-FAILURE; ATHEROSCLEROSIS;
   EXPRESSION; INJURY; OBESITY
AB Objectives
   Follistatin-like 1 (Fstl1) is a circulating glycoprotein that plays a crucial role in cardiovascular diseases and inflammation-related disorders. We have shown that Fstl1 acts as an anti-inflammatory factor that protects against ischemic heart disease and chronic kidney disease. Here we examined whether plasma level of Fstl1 associates with markers of inflammation and oxidative stress in apparently healthy Japanese men.
   Methods and Results
   Plasma Fstl1 levels were measured by enzyme-linked immunosorbent assay. Circulating Fstl1 concentrations positively correlated with levels of fasting immune-reactive insulin (FIRI), high-sensitive CRP (hsCRP) and derivatives of reactive oxidative metabolites (dROMs), an indicator of oxidative stress. The levels of hsCRP positively associated with Fstl1, body mass index (BMI), triglyceride, FIRI and dROMs levels. dROMs levels positively associated with Fstl1, Hemoglobin A1c and hsCRP levels. Multiple regression analysis with confounding factors revealed that Fstl1 levels, together with BMI and FIRI, correlated with hsCRP and that Fstl1 levels correlated with dROMs.
   Conclusion
   Our observations indicate that measurement of plasma Fstl1 levels can be valuable for assessment of pro-inflammatory and oxidative stress conditions.
C1 [Hayakawa, Satoko; Otaka, Naoya; Ogawa, Hayato; Ito, Masanori; Kanemura, Noriyoshi; Hiramatsu-Ito, Mizuho; Murohara, Toyoaki] Nagoya Univ, Grad Sch Med, Dept Cardiol, Nagoya, Aichi 4648601, Japan.
   [Ohashi, Koji; Ouchi, Noriyuki] Nagoya Univ, Grad Sch Med, Mol Cardiovasc Med, Nagoya, Aichi 4648601, Japan.
   [Shibata, Rei] Nagoya Univ, Grad Sch Med, Dept Adv Cardiovasc Therapeut, Nagoya, Aichi 4648601, Japan.
   [Takahashi, Ryotaro; Ikeda, Nobuo] Chunichi Hosp, Dept Cardiol, Nagoya, Aichi, Japan.
C3 Nagoya University; Nagoya University; Nagoya University
RP Ohashi, K; Ouchi, N (corresponding author), Nagoya Univ, Grad Sch Med, Mol Cardiovasc Med, Nagoya, Aichi 4648601, Japan.
EM ohashik@med.nagoya-u.ac.jp; nouchi@med.nagoya-u.ac.jp
RI Murohara, Toyoaki/M-4958-2014
OI Hiramatsu-Ito, Mizuho/0000-0003-1740-1794
FU Takeda Science Foundation; Uehara Memorial Foundation; Nakatomi
   Foundation
FX This work was supported by Grant-in-Aid for Scientific Research,
   Grant-in-Aid for Challenging Exploratory Research and grants from Takeda
   Science Foundation and the Uehara Memorial Foundation to N. Ouchi. K.
   Ohashi was supported with the Grant-in-Aid for Scientific Research C and
   The Nakatomi Foundation, 2015.
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NR 37
TC 26
Z9 26
U1 0
U2 12
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAY 4
PY 2016
VL 11
IS 5
AR e0153619
DI 10.1371/journal.pone.0153619
PG 8
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA DL5KR
UT WOS:000375676400022
PM 27145224
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Dahech, I
   Harrabi, B
   Hamden, K
   Feki, A
   Mejdoub, H
   Belghith, H
   Belghith, KS
AF Dahech, Imen
   Harrabi, Bahira
   Hamden, Khaled
   Feki, Abdelfattah
   Mejdoub, Hafedh
   Belghith, Hafedh
   Belghith, Karima Srih
TI Antioxidant effect of nondigestible levan and its impact on
   cardiovascular disease and atherosclerosis
SO INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
LA English
DT Article
DE Levan; Atherosclerosis; Cholesterol-fed rat; Antioxidant enzymes;
   Hypocholesterolemic effect
ID CORONARY-HEART-DISEASE; DIETARY FIBER; OXIDATIVE STRESS; LEVANSUCRASE;
   LIPOPROTEIN; INULIN; RISK
AB Levan polysaccharide, a type of fructan, has been shown to favorably affect diabetes type 2 and hypercholesterolemia. Recent reports have indicated that excessive oxidative stress contributes to the development of atherosclerosis linked metabolic syndrome. The objective of this current study was to investigate the possible protection against oxidative stress linked atherosclerosis. A group of twenty four male rats was divided into four subgroups; a normal diet group (Control), normal rats received levan (L), a high-cholesterol diet group (Chol) and a high-cholesterol diet with 5% (w/w) levan group. After the treatment period, the plasma antioxidant enzymes and lipid profiles were determined. Our results show that treatment with levan positively changed plasma antioxidant enzyme activities by increasing superoxide dismutase (SOD) and catalase (CAT) by 40% and 28%, respectively, in heart. Similarly, the treatment of Chol fed groups with levan positively changed lipid profiles by decreasing total cholesterol, triglycerides and LDL-cholesterol by 50%, 38.33% and 64%, respectively. Thus may have potential antioxidant effects and could protect against oxidative stress linked atherosclerosis. (C) 2013 Elsevier B.V. All rights reserved.
C1 [Dahech, Imen; Harrabi, Bahira; Mejdoub, Hafedh; Belghith, Karima Srih] Fac Sci Sfax, Biochem Lab, Sfax 3018, Tunisia.
   [Hamden, Khaled; Feki, Abdelfattah] Fac Sci Sfax, Sfax 3018, Tunisia.
   [Belghith, Hafedh] Univ Sfax, Biotechnol Ctr Sfax, Sfax 3018, Tunisia.
C3 Universite de Sfax; Faculty of Sciences Sfax; Ecole Nationale
   dIngenieurs de Sfax (ENIS); Universite de Sfax; Faculty of Sciences
   Sfax; Universite de Sfax; Centre de Biotechnologie de Sfax
RP Dahech, I (corresponding author), Univ Sfax, Fac Sci, Dept Life Sci, Biochem Lab, PB 802, Sfax 3018, Tunisia.
EM imenbiologie@yahoo.fr
RI ; HAMDEN, khaled/AAM-2452-2020
OI Hamden, Khaled/0009-0008-4278-5674; Hamdene, Khalid/0009-0003-0139-3301;
   HAMDEN, khaled/0000-0001-5651-3962
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NR 38
TC 47
Z9 52
U1 1
U2 23
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0141-8130
EI 1879-0003
J9 INT J BIOL MACROMOL
JI Int. J. Biol. Macromol.
PD JUL
PY 2013
VL 58
BP 281
EP 286
DI 10.1016/j.ijbiomac.2013.04.058
PG 6
WC Biochemistry & Molecular Biology; Chemistry, Applied; Polymer Science
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry; Polymer Science
GA 168ZJ
UT WOS:000320746200041
PM 23624165
DA 2025-06-11
ER

PT J
AU Cicuéndez, B
   Ruiz-Garrido, I
   Mora, A
   Sabio, G
AF Cicuendez, Beatriz
   Ruiz-Garrido, Irene
   Mora, Alfonso
   Sabio, Guadalupe
TI Stress kinases in the development of liver steatosis and hepatocellular
   carcinoma
SO MOLECULAR METABOLISM
LA English
DT Review
DE SAPK; JNK; p38; Steatosis; Hepatocarcinoma; Metabolism
ID NONALCOHOLIC FATTY LIVER; JUN NH2-TERMINAL KINASE; HEPATIC
   LIPID-ACCUMULATION; P38 MAP-KINASES; C-JUN; INSULIN-RESISTANCE; T-CELLS;
   OXIDATIVE STRESS; AIRWAY INFLAMMATION; PERIPHERAL-TISSUES
AB Non-alcoholic fatty liver disease (NAFLD) is an important component of metabolic syndrome and one of the most prevalent liver diseases worldwide. This disorder is closely linked to hepatic insulin resistance, lipotoxicity, and inflammation. Although the mechanisms that cause steatosis and chronic liver injury in NAFLD remain unclear, a key component of this process is the activation of stress-activated kinases (SAPKs), including p38 and JNK in the liver and immune system. This review summarizes findings which indicate that the dysregulation of stress kinases plays a fundamental role in the development of steatosis and are important players in inducing liver fibrosis. To avoid the development of steatohepatitis and liver cancer, SAPK activity must be tightly regulated not only in the hepatocytes but also in other tissues, including cells of the immune system. Possible cellular mechanisms of SAPK actions are discussed. (c) 2021 The Authors. Published by Elsevier GmbH. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
C1 [Cicuendez, Beatriz; Ruiz-Garrido, Irene; Mora, Alfonso; Sabio, Guadalupe] Ctr Nacl Invest Cardiovasc CNIC, Madrid 28029, Spain.
C3 Centro Nacional de Investigaciones Cardiovasculares (CNIC)
RP Mora, A; Sabio, G (corresponding author), Ctr Nacl Invest Cardiovasc CNIC, Madrid 28029, Spain.
EM amora@cnic.es; gsabio@cnic.es
RI Mora, Alfonso/D-2759-2017; Cicuendez, Beatriz/HTR-3204-2023; Sabio,
   Guadalupe/H-9733-2015
OI Sabio, Guadalupe/0000-0002-2822-0625; Cicuendez,
   Beatriz/0000-0002-5810-5185; Mora, Alfonso/0000-0002-6397-4836
FU European Union Seventh Framework Programme (FP7/2007-2013) ERC [260464];
   EFSD/Lilly Eu-ropean Diabetes Research Programme; BBVA Foundation [IN
   [17] _BBM_BAS_0066]; Ministerio de Economia y Competitividad
   [MINECO-FEDER SAF2016-79126-R, PID2019104399RBI00]; Fundacion AECC
   [PROYE19047SABI]; Comunidad de Madrid [IMMUNOTHERCAN-CM S2010/BMD-2326,
   B2017/BMD3733]; Ministerio de Ciencia, Innovacion y Universidades (MCNU)
   Ministerio de Ciencia, Innovacion y Universidades; Pro CNIC Foundation;
   Severo Ochoa Center of Excellence [SEV20150505]; European Research
   Council (ERC) [260464] Funding Source: European Research Council (ERC)
FX We thank S. Bartlett for English editing. GS receives funding from the
   European Union Seventh Framework Programme (FP7/2007-2013) ERC 260464,
   the EFSD/Lilly Eu-ropean Diabetes Research Programme, a Leonardo Grant
   for Researchers and Cultural Creators from the BBVA Foundation
   (InvestigadoresBBVA2017) IN [17] _BBM_BAS_0066, the Ministerio de
   Economia y Competitividad (MINECO-FEDER SAF2016-79126-R and
   PID2019104399RBI00) , the Fundacion AECC (PROYE19047SABI) , and the
   Comunidad de Madrid (IMMUNOTHERCAN-CM S2010/BMD-2326 and B2017/BMD3733)
   . The CNIC is supported by the Ministerio de Ciencia, Innovacion y
   Universidades (MCNU) Ministerio de Ciencia, Innovacion y Universidades,
   and the Pro CNIC Foundation and is a Severo Ochoa Center of Excellence
   (SEV20150505) . We thank our collaborators and all the students and
   fellows who have contributed to studies in the Sabio group over the
   years. We regret the inadvertent omission of important references due to
   space limitations.
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NR 219
TC 34
Z9 34
U1 1
U2 8
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2212-8778
J9 MOL METAB
JI Mol. Metab.
PD AUG
PY 2020
VL 50
AR 101190
DI 10.1016/j.molmet.2021.101190
PG 20
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA TP3OQ
UT WOS:000677503500004
PM 33588102
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Ishigooka, J
   Kato, T
   Miyajima, M
   Watabe, K
   Masuda, T
   Hagi, K
   Higuchi, T
AF Ishigooka, Jun
   Kato, Tadafumi
   Miyajima, Mari
   Watabe, Kei
   Masuda, Takahiro
   Hagi, Katsuhiko
   Higuchi, Teruhiko
TI Lurasidone in the Long-Term Treatment of Bipolar I Depression: A 28-week
   Open Label Extension Study
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Lurasidone; Bipolar disorder; Bipolar depression; Major depressive
   episode; Atypical antipsychotic
ID DOUBLE-BLIND; METABOLIC SYNDROME; DISORDER; SCALE; METAANALYSIS;
   RELIABILITY; MONOTHERAPY; PREVALENCE; OLANZAPINE; VALIDITY
AB Background: Lurasidone has demonstrated efficacy for short-term treatment of bipolar depression in a diverse ethnic population including Japanese. This study evaluated the long-term safety and effectiveness of open-label lurasidone treatment in these patients.
   Methods: Patients for this 28-week extension study were recruited from those who completed a 6-week doubleblind study of lurasidone, 20-60 mg/day, lurasidone 80-120 mg/day, and placebo. In the extension study, lurasidone was flexibly dosed (20 to 120 mg/day). Safety was evaluated in terms of change from extension-phase baseline to endpoint including adverse events, vital signs, body weight, ECG, laboratory tests, and measures of suicidality and extrapyramidal symptoms. Effectiveness was determined by Montgomery angstrom sberg Depression Rating Scale (MADRS) and other measures.
   Results: 303 of 413 (73.3%) subjects completed the extension study. Discontinuation due to a treatment-emergent adverse event occurred for 11.4% of those who received placebo, and 8.9% of those who received lurasidone, in the prior 6-week trial. The most common treatment-emergent adverse event was akathisia. Minimal changes were evident on body weight and metabolic parameters. Long-term treatment with lurasidone further reduced mean MADRS total scores from long-term baseline to week 28 (or endpoint) for both those who had received prior placebo (-11.3), and those who had receive prior lurasidone (-8.9), in the 6-week double-blind trial.
   Limitations: There was no placebo control and treatment was not double-blind.
   Conclusions: Long-term treatment with lurasidone (20-120 mg/day) was well-tolerated with no new safety concerns and associated with continued improvement in depressive symptoms in this international sample of patients with bipolar depression. Clinical trial registration: JapicCTI-132319, clinicaltrials.gov NCT01986114
C1 [Ishigooka, Jun] Inst CNS Pharmacol, Tokyo, Japan.
   [Kato, Tadafumi] RIKEN Ctr Brain Sci, Lab Mol Dynam Mental Disorders, Wako, Saitama, Japan.
   [Kato, Tadafumi] Juntendo Univ, Dept Psychiat, Tokyo, Japan.
   [Miyajima, Mari; Watabe, Kei; Masuda, Takahiro; Hagi, Katsuhiko] Sumitomo Dainippon Pharma Co Ltd, Tokyo, Japan.
   [Higuchi, Teruhiko] Japan Depress Ctr, Tokyo, Japan.
   [Higuchi, Teruhiko] Natl Ctr Neurol & Psychiat, Tokyo, Japan.
C3 RIKEN; Juntendo University; Dainippon Sumitomo Pharmaceutical Company;
   National Center for Neurology & Psychiatry - Japan
RP Hagi, K (corresponding author), Sumitomo Dainippon Pharma Co Ltd, Med Affairs, Chuo Ku, 13-1,Kyobashi 1 Chome, Tokyo 1048356, Japan.
EM katsuhiko-hagi@ds-pharma.co.jp
RI Kato, Tadafumi/J-3583-2014
FU Sumitomo Dainippon Pharma Co., Ltd., Tokyo Japan
FX This study was supported by Sumitomo Dainippon Pharma Co., Ltd., Tokyo
   Japan.
CR Bai YM, 2016, BMC PSYCHIATRY, V16, DOI 10.1186/s12888-016-1143-8
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NR 28
TC 8
Z9 8
U1 0
U2 10
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD FEB 15
PY 2021
VL 281
BP 160
EP 167
DI 10.1016/j.jad.2020.12.005
PG 8
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA PY8SI
UT WOS:000612310700022
PM 33321381
OA hybrid
DA 2025-06-11
ER

PT J
AU Shan, B
   Wang, XX
   Wu, Y
   Xu, C
   Xia, ZX
   Dai, JL
   Shao, ML
   Zhao, F
   He, SQ
   Yang, L
   Zhang, ML
   Nan, FJ
   Li, J
   Liu, JM
   Liu, JF
   Jia, WP
   Qiu, YF
   Song, BL
   Han, JDJ
   Rui, LY
   Duan, SZ
   Liu, Y
AF Shan, Bo
   Wang, Xiaoxia
   Wu, Ying
   Xu, Chi
   Xia, Zhixiong
   Dai, Jianli
   Shao, Mengle
   Zhao, Feng
   He, Shengqi
   Yang, Liu
   Zhang, Mingliang
   Nan, Fajun
   Li, Jia
   Liu, Jianmiao
   Liu, Jianfeng
   Jia, Weiping
   Qiu, Yifu
   Song, Baoliang
   Han, Jing-Dong J.
   Rui, Liangyou
   Duan, Sheng-Zhong
   Liu, Yong
TI The metabolic ER stress sensor IRE1α suppresses alternative activation
   of macrophages and impairs energy expenditure in obesity
SO NATURE IMMUNOLOGY
LA English
DT Article
ID UNFOLDED PROTEIN RESPONSE; ENDOPLASMIC-RETICULUM; ADIPOSE-TISSUE; BEIGE
   FAT; POLARIZATION; DISEASE; INSULIN; CELL; THERMOGENESIS; INFLAMMATION
AB Obesity is associated with metabolic inflammation and endoplasmic reticulum (ER) stress, both of which promote metabolic disease progression. Adipose tissue macrophages (ATMs) are key players orchestrating metabolic inflammation, and ER stress enhances macrophage activation. However, whether ER stress pathways underlie ATM regulation of energy homeostasis remains unclear. Here, we identified inositol-requiring enzyme 1 alpha (IRE1 alpha) as a critical switch governing M1-M2 macrophage polarization and energy balance. Myeloid-specific IRE1 alpha abrogation in Ern1(f/f); Lyz2-Cre mice largely reversed high-fat diet (HFD)-induced M1-M2 imbalance in white adipose tissue (WAT) and blocked HFD-induced obesity, insulin resistance, hyperlipidemia and hepatic steatosis. Brown adipose tissue (BAT) activity, WAT browning and energy expenditure were significantly higher in Ern1(f/f); Lyz2-Cre mice. Furthermore, IRE1 alpha ablation augmented M2 polarization of macrophages in a cell-autonomous manner. Thus, IRE1 alpha senses protein unfolding and metabolic and immunological states, and consequently guides ATM polarization. The macrophage IRE1 alpha pathway drives obesity and metabolic syndrome through impairing BAT activity and WAT browning.
C1 [Shan, Bo; Wang, Xiaoxia; Wu, Ying; Dai, Jianli; Zhao, Feng; He, Shengqi; Duan, Sheng-Zhong] Univ Chinese Acad Sci, Chinese Acad Sci, Shanghai Inst Biol Sci, Key Lab Nutr & Metab,Inst Nutr Sci, Shanghai, Peoples R China.
   [Xu, Chi; Han, Jing-Dong J.] Chinese Acad Sci, Shanghai Inst Biol Sci, Key Lab Computat Biol, Chinese Acad Sci Max Planck Partner Inst Computat, Shanghai, Peoples R China.
   [Xia, Zhixiong; Liu, Jianmiao; Liu, Jianfeng] Huazhong Univ Sci & Technol, Minist Educ, Key Lab Mol Biophys, Cellular Signaling Lab, Wuhan, Peoples R China.
   [Shao, Mengle] Univ Texas Southwestern Med Ctr Dallas, Dept Internal Med, Touchstone Diabet Ctr, Dallas, TX 75390 USA.
   [He, Shengqi; Song, Baoliang; Liu, Yong] Wuhan Univ, Inst Adv Studies, Coll Life Sci, Hubei Key Lab Cell Homeostasis, Wuhan, Peoples R China.
   [Yang, Liu; Zhang, Mingliang; Jia, Weiping] Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Shanghai Diabet Inst,Shanghai Key Lab Diabet Mell, Shanghai Clin Ctr Diabet,Dept Endocrinol & Metab, Shanghai, Peoples R China.
   [Nan, Fajun; Li, Jia] Chinese Acad Sci, Shanghai Inst Mat Med, Natl Ctr Drug Screening, Shanghai, Peoples R China.
   [Qiu, Yifu] Peking Univ, Beijing Key Lab Cardiometab Mol Med, Acad Adv Interdisciplinary Studies, Inst Mol Med,Peking Tsinghua Ctr Life Sci, Beijing, Peoples R China.
   [Rui, Liangyou] Univ Michigan, Med Sch, Dept Mol & Integrat Physiol, Ann Arbor, MI 48109 USA.
C3 Chinese Academy of Sciences; University of Chinese Academy of Sciences,
   CAS; Chinese Academy of Sciences; Max Planck Society; Huazhong
   University of Science & Technology; Ministry of Education - China;
   University of Texas System; University of Texas Southwestern Medical
   Center Dallas; Wuhan University; Shanghai Jiao Tong University; Chinese
   Academy of Sciences; Shanghai Institute of Materia Medica, CAS; Peking
   University; University of Michigan System; University of Michigan
RP Duan, SZ (corresponding author), Univ Chinese Acad Sci, Chinese Acad Sci, Shanghai Inst Biol Sci, Key Lab Nutr & Metab,Inst Nutr Sci, Shanghai, Peoples R China.; Liu, Y (corresponding author), Wuhan Univ, Inst Adv Studies, Coll Life Sci, Hubei Key Lab Cell Homeostasis, Wuhan, Peoples R China.
EM szduan@sibs.ac.cn; liuyong31279@whu.edu.cn
RI Xu, Chi/H-9523-2018; Liu, Jiacheng/KHX-5326-2024; Han,
   Jing/MDS-8233-2025; Liu, Jian-Feng/Q-2096-2019; Liu, Yong/R-4019-2017;
   SHAN, BO/AAC-5167-2021; Shao, Mengle/AAH-8392-2019; Li, Jia/F-9116-2011;
   Shao, Mengle/D-9951-2014; Jia, Weiping/B-7483-2012
OI Shao, Mengle/0000-0002-5488-9904; Song, Bao-Liang/0000-0002-6397-5935;
   Shan, Bo/0000-0002-1675-5809; Wu, Ying/0009-0008-1808-3349; Jia,
   Weiping/0000-0002-6244-2168
FU Ministry of Science and Technology [2016YFA0500100]; Ministry of Science
   and Technology (973 Program) [2012CB524900]; National Natural Science
   Foundation of China [81420108006, 31690102, 31230036, 31671181,
   31371153, 91539107, 31671227, 91642113]; European Foundation for the
   Study of Diabetes/Chinese Diabetes Society/Lilly Programme
FX We thank S. Kajimura from UCSF for the beige preadipocytes and C. Jiang
   from Peking University for assistance with the macrophage depletion
   experiments. This work was supported by grants from the Ministry of
   Science and Technology (2016YFA0500100 and 973 Program 2012CB524900) and
   the National Natural Science Foundation of China (81420108006, 31690102
   and 31230036) to Y.L.; the National Natural Science Foundation of China
   (31671181 and 31371153) to S.Z.D.; the National Natural Science
   Foundation of China (91539107) to Jianmiao Liu; and the National Natural
   Science Foundation of China (31671227 and 91642113) to Y.Q. This work
   was also supported by a research grant from the European Foundation for
   the Study of Diabetes/Chinese Diabetes Society/Lilly Programme to Y.L.
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NR 46
TC 295
Z9 323
U1 10
U2 207
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 1529-2908
EI 1529-2916
J9 NAT IMMUNOL
JI Nat. Immunol.
PD MAY
PY 2017
VL 18
IS 5
BP 519
EP 529
DI 10.1038/ni.3709
PG 11
WC Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology
GA ES2SR
UT WOS:000399378700009
PM 28346409
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Hibner, TA
   Wakefield, AN
   Eaves, SM
   Gonzalvo, JD
   Macik, MR
   Williams, GD
AF Hibner, Taylor A.
   Wakefield, Andrew N.
   Eaves, Shannon M.
   Gonzalvo, Jasmine D.
   Macik, Monica R.
   Williams, Gabriela D.
TI Metabolic monitoring of second-generation antipsychotics: Evaluation of
   a pharmacist- and nurse-driven protocol
SO JOURNAL OF THE AMERICAN PHARMACISTS ASSOCIATION
LA English
DT Article
ID OF-CARE; RISK; SCHIZOPHRENIA; PROGRAM
AB Objective: Second-generation antipsychotic therapy can lead to metabolic abnormalities, increasing the risk of cardiovascular disease and death in patients with serious mental illness. However, the literature suggests there is a lack of appropriate monitoring in individuals receiving these therapies. This study aims to evaluate whether the implementation of a pharmacist- and nurse-driven metabolic monitoring protocol will increase monitoring in patients prescribed second-generation antipsychotic therapy in an outpatient community mental health clinic.
   Methods: A retrospective review of adult outpatients in a community mental health clinic who were prescribed second-generation antipsychotics was conducted from October 1, 2017, to March 31, 2019. Pre- and postprotocol implementation groups were compared to assess the impact of the protocol on the primary outcome of appropriateness in monitoring for metabolic parameters.
   Results: A total of 160 patients who met the inclusion criteria were randomly selected and reviewed, allowing for 80 individuals in each group. Improvement in the appropriateness of monitoring was found for 4 of 5 metabolic parameters after protocol implementation, including blood pressure (17.5% to 43.8%, P < 0.001), weight (17.5% to 43.8%, P < 0.001), hemoglobin A1C (27.5% to 42.5%, P = 0.044), and lipid levels (17.5% to 31.3%, P = 0.04). Primary care physicians ordered most of the laboratory values (44.5% to 46.2%); however, pharmacists and nurses ordered 7% of laboratory tests after the protocol implementation.
   Conclusion: Despite the knowledge that second-generation antipsychotic therapies commonly lead to metabolic syndrome and therefore increased cardiovascular disease risk, monitoring for metabolic effects remains poor, and there is a lack in diversity of strategies to improve this monitoring. Although further research on the effectiveness of a pharmacist- and nurse-driven metabolic monitoring protocol in this setting is warranted, this protocol serves as an example of a novel strategy with the potential to improve metabolic monitoring of second-generation antipsychotic therapy. (C) 2020 American Pharmacists Association (R). Published by Elsevier Inc. All rights reserved.
C1 [Hibner, Taylor A.] Community Hlth Network, Indianapolis, IN USA.
   [Hibner, Taylor A.] Eskenazi Hlth, Dept Pharm, 720 Eskenazi Ave, Indianapolis, IN 46202 USA.
   [Wakefield, Andrew N.] Parkland Hlth & Hosp Syst, Dept Pharm, Dallas, TX USA.
   [Wakefield, Andrew N.; Gonzalvo, Jasmine D.] Purdue Univ, Coll Pharm, W Lafayette, IN 47907 USA.
   [Eaves, Shannon M.] UC San Diego Hlth, San Diego, CA USA.
   [Eaves, Shannon M.; Williams, Gabriela D.] Eskenazi Hlth, Dept Pharm, Psychiat, Indianapolis, IN 46202 USA.
   [Gonzalvo, Jasmine D.] Eskenazi Hlth, Dept Pharm, Ambulatory Care, Indianapolis, IN 46202 USA.
   [Macik, Monica R.] Eskenazi Hlth, Dept Pharm, Hematol Oncol, Indianapolis, IN 46202 USA.
   [Williams, Gabriela D.] Genomind Inc, King Of Prussia, PA USA.
C3 Eskenazi Health; Purdue University System; Purdue University; Eskenazi
   Health; Eskenazi Health; Eskenazi Health
RP Hibner, TA (corresponding author), Eskenazi Hlth, Dept Pharm, 720 Eskenazi Ave, Indianapolis, IN 46202 USA.
EM taylorhibner@gmail.com
OI Macik, Monica/0000-0002-6781-8216
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NR 17
TC 7
Z9 9
U1 0
U2 4
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1544-3191
EI 1544-3450
J9 J AM PHARM ASSOC
JI J. Am. Pharm. Assoc.
PD SEP-OCT
PY 2020
VL 60
IS 5
SU S
BP S88
EP S92
DI 10.1016/j.japh.2020.04.016
PG 5
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Pharmacology & Pharmacy
GA OD7OD
UT WOS:000580037500013
PM 32513507
DA 2025-06-11
ER

PT J
AU Tricot, S
   Mimouni, V
   Rompion, S
   Froger, C
   Lacroix, P
   Roux, S
   Ulmann, L
AF Tricot, Sompadthana
   Mimouni, Virginie
   Rompion, Sonia
   Froger, Christelle
   Lacroix, Pierre
   Roux, Sylvain
   Ulmann, Lionel
TI No altered blood pressure and serum markers of oxidative stress after a
   long time dietary fish oil in the genetically 9 month-old type-2
   diabetes Zucker rat
SO PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
LA English
DT Article
DE Fish oil; Zucker rats; Telemetry; Blood pressure; Oxidative stress
ID NITRIC-OXIDE SYNTHASE; POLYUNSATURATED FATTY-ACIDS;
   CONVERTING-ENZYME-ACTIVITY; DOCOSAHEXAENOIC ACID; LIPID-METABOLISM;
   EICOSAPENTAENOIC ACID; ENDOTHELIAL FUNCTION; ANTIOXIDANT STATUS;
   ANGIOTENSIN-II; MESSENGER-RNA
AB In this study, we investigated the effect of a high n-3 fatty acid diet (eicosapentaenoic and docosahexaenoic acids) in Zucker obese and lean rats on blood pressure in association with physiological parameters, serum biochemistry and oxidative stress analysis.
   After 150 days of treatment, dietary fish oil supplementation in Zucker obese rats (9 months of age) reduces bodyweight gain and serum triglyceridemia and nitrite levels, increases serum glucose and angiotensin converting enzyme activity, but does not alter blood pressure, cholesterol levels and serum markers of oxidative stress (malondialdehyde, glutathione), compared to the Zucker rats fed control diet.
   According to these results, we can consider that after 150 days of treatment, fish oil is not enough to regulate parameters involved in the metabolic syndrome, such as cholesterolemia and blood pressure, in a 9 month-old genetically type-2 diabetes rat. (C) 2010 Elsevier Ltd. All rights reserved.
C1 [Tricot, Sompadthana; Mimouni, Virginie; Ulmann, Lionel] Univ Maine, IUT Laval, Dept Genie Biol, PRES UNAM,EA Mer Mol Sante 2160, F-53020 Laval 9, France.
   [Rompion, Sonia; Froger, Christelle; Lacroix, Pierre; Roux, Sylvain] Porsolt & Partners Pharmacol, F-92100 Boulogne, France.
C3 Le Mans Universite
RP Ulmann, L (corresponding author), Univ Maine, IUT Laval, Dept Genie Biol, PRES UNAM,EA Mer Mol Sante 2160, 52 Rue Drs Calmette & Guerin,BP 2045, F-53020 Laval 9, France.
EM lulman@univ-lemans.fr
RI ; Ulmann, Lionel/AAC-6561-2019
OI Mimouni, Virginie/0000-0002-2468-0659; Ulmann,
   Lionel/0000-0002-9009-2791
FU local collectivities of the Mayenne, France
FX This work was supported by grants from the local collectivities of the
   Mayenne, France. The authors are grateful to Monika Ghosh for English
   revision of the manuscript. Thank Philippe Guillaume and Isabelle Fauque
   (Porsolt and Partners Pharmacology, Le Genest Saint Isle, France) for
   technical assistance in physiological measurements, and Marie Mathieu
   (ONIRIS, Nantes, France) for statistical analysis.
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NR 61
TC 2
Z9 3
U1 0
U2 3
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0952-3278
EI 1532-2823
J9 PROSTAG LEUKOTR ESS
JI Prostaglandins Leukot. Essent. Fatty Acids
PD OCT-DEC
PY 2010
VL 83
IS 4-6
BP 211
EP 218
DI 10.1016/j.plefa.2010.08.005
PG 8
WC Biochemistry & Molecular Biology; Cell Biology; Endocrinology &
   Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology; Endocrinology &
   Metabolism
GA 703BQ
UT WOS:000285949400006
PM 20833009
DA 2025-06-11
ER

PT J
AU Golbidi, S
   Edvinsson, L
   Laher, I
AF Golbidi, Saeid
   Edvinsson, Lars
   Laher, Ismail
TI Smoking and Endothelial Dysfunction
SO CURRENT VASCULAR PHARMACOLOGY
LA English
DT Review
DE Smoking; e-cigarette; oxidative stress; endothelial dysfunction;
   atherosclerosis; cardiovascular function
ID OBSTRUCTIVE PULMONARY-DISEASE; CARDIOVASCULAR RISK-FACTORS;
   BRAIN-BARRIER PERMEABILITY; NICOTINE DELIVERY-SYSTEMS; NITRIC-OXIDE
   SYNTHASE; HIGH-SCHOOL-STUDENTS; CIGARETTE-SMOKE; OXIDATIVE STRESS;
   ELECTRONIC CIGARETTES; METABOLIC SYNDROME
AB Cigarette smoking is one of the most important health concerns worldwide. Even though the rate of smoking is declining in developed countries, it is still experiencing growth in developing regions. Many studies have examined the relationship between smoking, as an established risk factor, and cardiovascular diseases. We provide an updated review of the underlying mechanisms of smokinginduced cardiovascular diseases, with a focus on the relationship between smoking and oxidative stress, particularly from the perspective of endothelial cell dysfunction. We review smoking-induced oxidative stress as a trigger for a generalized vascular inflammation associated with cytokine release, adhesion of inflammatory cells and, ultimately, disruption of endothelial integrity as a protective barrier layer. We also briefly discuss the harms related to the vaping of electronic cigarettes, which many erroneously consider as a safe alternative to smoking. We conclude that even though e-cigarette could be a helpful device during the transition period of cigarette quitting, it is by no means a safe substitute.
C1 [Golbidi, Saeid] Univ British Columbia, Fac Med, Dept Family Practice, Vancouver, BC, Canada.
   [Edvinsson, Lars] Lund Univ, Inst Clin Sci, Dept Med, S-22185 Lund, Sweden.
   [Laher, Ismail] Univ British Columbia, Fac Med, Dept Pharmacol & Therapeut, 2176 Hlth Sci Mall, Vancouver, BC V6T 1Z3, Canada.
C3 University of British Columbia; Lund University; University of British
   Columbia
RP Laher, I (corresponding author), Univ British Columbia, Fac Med, Dept Pharmacol & Therapeut, 2176 Hlth Sci Mall, Vancouver, BC V6T 1Z3, Canada.
EM ilaher@mail.ubc.ca
OI Edvinsson, Lars/0000-0002-1805-1346
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NR 174
TC 54
Z9 61
U1 0
U2 24
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1570-1611
EI 1875-6212
J9 CURR VASC PHARMACOL
JI Current Vascular Pharmacology
PY 2020
VL 18
IS 1
BP 1
EP 11
DI 10.2174/1573403X14666180913120015
PG 11
WC Pharmacology & Pharmacy; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Cardiovascular System & Cardiology
GA KG2EN
UT WOS:000509754200001
PM 30210003
DA 2025-06-11
ER

PT J
AU Yang, RL
   Li, W
   Yue, P
   Shi, YH
   Le, GW
AF Yang, Rui-li
   Li, Wu
   Yue, Peng
   Shi, Yong-Hui
   Le, Guo-Wei
TI Relation of plasma somatostatin levels with malondialdehyde in
   hyperlipidemic patients
SO ASIA PACIFIC JOURNAL OF CLINICAL NUTRITION
LA English
DT Article
DE somatostatin; insulin resistance; oxidative stress; malondialdehyde;
   hyperlipidemia
ID INSULIN-RESISTANCE; METABOLIC SYNDROME; OXIDATIVE STRESS; RECEPTOR
   LIGANDS; OBESITY; GLUCOSE; ABSORPTION; OCTREOTIDE; DISORDERS; DISEASE
AB Somatostatin (SST) may protect organism from overnutrition-induced insulin resistance and oxidative stress by inhibiting pancreatic endocrine and exocrine secretion, gastrointestinal digestion and absorption. Many studies clearly show its release becomes perturbed in diabetes and obesity. Therefore, in the present study we first aimed to investigate whether or not plasma somatostatin level was different in patients with hyperlipidemia and normolipidemic controls. We also assessed the relationship between plasma somatostatin levels with atherosclerotic index (AI) and malondialdehyde (MDA) in non-diabetic dyslipidemic patients. Subjects with hyperlipidemia have insulin resistance and high levels of oxidative stress. Median somatostatin (57.2+/-19.2 vs 68.0+/-21.9 pg/mL; p<0.05) levels were lower in hyperlipidemic than in normolipidemic subjects. Significant inverse relationships between SST level and AI (r=-0.21, p<0.05), or MDA (r=-0.31, p<0.01) were observed. These results suggest a possible protective role of endogenous SST, at least on hyperlipidemia and atherosclerosis that are attributed to excess energy intake and physical inactivity. Of course these preliminary results should be supported by prospective studies.
C1 [Yang, Rui-li; Li, Wu; Yue, Peng; Shi, Yong-Hui; Le, Guo-Wei] Jiangnan Univ, State Key Lab Food Sci & Technol, Wuxi 214122, Jiangsu Prov, Peoples R China.
   [Yang, Rui-li] S China Agr Univ, Coll Food Sci, Key Lab Food Qual & Safety Guangdong Prov, Guangzhou, Guangdong, Peoples R China.
C3 Jiangnan University; South China Agricultural University
RP Le, GW (corresponding author), Jiangnan Univ, State Key Lab Food Sci & Technol, 1800 Lihu Rd, Wuxi 214122, Jiangsu Prov, Peoples R China.
EM lgw@sytu.edu.cn
RI li, wu/AAG-2304-2020; SHI, YH/HLG-1159-2023
OI li, wu/0000-0003-3942-0515; yang, ruili/0000-0001-6347-3196
FU National Natural Science Foundation of China [30571347]
FX This work was supported by National Natural Science Foundation of China
   (No. 30571347). We are grateful to the physicians Fang Xu, Li-Hua Wang,
   and Jin-Feng Liu in the Jiangnan University hospital for referral of
   people for the study and blood extractions, and to the study
   participants for their cooperation.
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NR 28
TC 1
Z9 1
U1 0
U2 3
PU H E C PRESS, HEALTHY EATING CLUB PTY LTD
PI MCKINNON
PA PO BOX 4121, MCKINNON, VIC 3204, AUSTRALIA
SN 0964-7058
J9 ASIA PAC J CLIN NUTR
JI Asia Pac. J. Clin. Nutr.
PY 2011
VL 20
IS 2
BP 220
EP 224
PG 5
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 787JP
UT WOS:000292372700013
PM 21669591
DA 2025-06-11
ER

PT J
AU Collins, AR
   Lyon, CJ
   Xia, XF
   Liu, JZ
   Tangirala, RK
   Yin, F
   Boyadjian, R
   Bikineyeva, A
   Praticò, D
   Harrison, DG
   Hsueh, WA
AF Collins, Alan R.
   Lyon, Christopher J.
   Xia, Xuefeng
   Liu, Joey Z.
   Tangirala, Rajendra K.
   Yin, Fen
   Boyadjian, Rima
   Bikineyeva, Alfiya
   Pratico, Domenico
   Harrison, David G.
   Hsueh, Willa A.
TI Age-Accelerated Atherosclerosis Correlates With Failure to Upregulate
   Antioxidant Genes
SO CIRCULATION RESEARCH
LA English
DT Article
DE aging; atherosclerosis; basic research; mouse; oxidative stress
ID RECEPTOR-DEFICIENT MICE; 2 DIFFERENT STRAINS; OXIDATIVE STRESS; CALORIC
   RESTRICTION; REDUCES ATHEROSCLEROSIS; GLUTATHIONE-PEROXIDASE;
   INSULIN-RESISTANCE; REACTIVE OXYGEN; KNOCKOUT MICE; MOUSE MODELS
AB Excess food intake leads to obesity and diabetes, both of which are well-known independent risk factors for atherosclerosis, and both of which are growing epidemics in an aging population. We hypothesized that aging enhances the metabolic and vascular effects of high fat diet (HFD) and therefore examined the effect of age on atherosclerosis and insulin resistance in lipoprotein receptor knockout (LDLR-/-) mice. We found that 12-month-old (middle-aged) LDLR-/- mice developed substantially worse metabolic syndrome, diabetes, and atherosclerosis than 3-month-old (young) LDLR-/- mice when both were fed HFD for 3 months, despite similar elevations in total cholesterol levels. Microarray analyses were performed to analyze the mechanism responsible for the marked acceleration of atherosclerosis in middle-aged mice. Chow-fed middle-aged mice had greater aortic expression of multiple antioxidant genes than chow-fed young mice, including glutathione peroxidase-1 and -4, catalase, superoxide dismutase-2, and uncoupling protein-2. Aortic expression of these enzymes markedly increased in young mice fed HFD but decreased or only modestly increased in middle-aged mice fed HFD, despite the fact that systemic oxidative stress and vascular reactive oxygen species generation, measured by plasma F2 alpha isoprostane concentration (systemic) and dihydroethidium conversion and p47phox expression (vascular), were greater in middle-aged mice fed HFD. Thus, the mechanism for the accelerated vascular injury in older LDLR-/- mice was likely the profound inability to mount an antioxidant response. This effect was related to a decrease in vascular expression of 2 key transcriptional pathways regulating the antioxidant response, DJ-1 and forkhead box, subgroup O family (FOXOs). Treatment of middle-aged mice fed HFD with the antioxidant apocynin attenuated atherosclerosis, whereas treatment with the insulin sensitizer rosiglitazone attenuated both metabolic syndrome and atherosclerosis. Both treatments decreased oxidative stress. A novel effect of rosiglitazone was to increase expression of Nrf2 (nuclear factor [erythroid-derived 2]-like 2), a downstream target of DJ-1 contributing to enhanced expression of vascular antioxidant enzymes. This investigation underscores the role of oxidative stress when multiple atherosclerotic risk factors, particularly aging, converge on the vessel wall and emphasizes the need to develop effective strategies to inhibit oxidative stress to protect aging vasculature. (Circ Res. 2009; 104: e42-e54.)
C1 [Collins, Alan R.; Lyon, Christopher J.; Xia, Xuefeng; Liu, Joey Z.; Hsueh, Willa A.] Methodist Hosp, Res Inst, Ctr Diabet Res, Weill Cornell Med Coll, Houston, TX 77030 USA.
   [Tangirala, Rajendra K.; Yin, Fen; Boyadjian, Rima] Univ Calif Los Angeles, David Geffen Sch Med, Div Endocrinol Diabet & Hypertens, Los Angeles, CA 90095 USA.
   [Bikineyeva, Alfiya] Emory Sch Med, Dept Med, Div Cardiol, Atlanta, GA USA.
   [Pratico, Domenico] Temple Univ, Sch Med, Dept Pharmacol, Philadelphia, PA 19122 USA.
C3 Cornell University; Houston Methodist; University of California System;
   University of California Los Angeles; University of California Los
   Angeles Medical Center; David Geffen School of Medicine at UCLA; Emory
   University; Pennsylvania Commonwealth System of Higher Education
   (PCSHE); Temple University
RP Hsueh, WA (corresponding author), Methodist Hosp, Res Inst, Ctr Diabet Res, Weill Cornell Med Coll, 6565 Fannin St,F7-070, Houston, TX 77030 USA.
EM wahsueh@tmhs.org
RI Xiao, Liuling/AFR-2506-2022; Pratico, Domenico/ABA-9590-2020; Harrison,
   David/ITT-6732-2023
FU NIH [U01 HL70526]
FX This work was supported in part by NIH grants U01 HL70526 ("Novel Models
   of Cardiovascular Complications of Diabetes") ( to W. A. H.) and R01
   HL75171-2 ( to W. A. H.).
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NR 56
TC 185
Z9 210
U1 0
U2 15
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0009-7330
EI 1524-4571
J9 CIRC RES
JI Circ.Res.
PD MAR 27
PY 2009
VL 104
IS 6
BP e42
EP E54
DI 10.1161/CIRCRESAHA.108.188771
PG 13
WC Cardiac & Cardiovascular Systems; Hematology; Peripheral Vascular
   Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Hematology
GA 424KM
UT WOS:000264565600018
PM 19265038
OA Bronze
DA 2025-06-11
ER

PT J
AU Ruiz, JS
   Garcia, JB
   Ruiloba, JV
   Ubago, JG
   González, MPGP
AF Saiz Ruiz, J.
   Bobes Garcia, J.
   Vallejo Ruiloba, J.
   Giner Ubago, J.
   Garcia-Portilla Gonzalez, M. P.
CA Work Grp Phys Hlth Patient Schizop
TI Consensus on physical health of patients with schizophrenia from the
   Spanish Societies of Psychiatry and Biological Psychiatry
SO ACTAS ESPANOLAS DE PSIQUIATRIA
LA English
DT Review
DE Schizophrenia; Physical health; Morbidity; Mortality; Intervention
   guides
ID SERIOUS MENTAL-ILLNESS; DIABETES-MELLITUS; EXCESS MORTALITY; METABOLIC
   SYNDROME; NEUROLEPTIC-NAIVE; HEART-DISEASE; FOLLOW-UP; CARDIOVASCULAR
   PROCEDURES; NEUROLOGIC ORGANIZATION; ANTIPSYCHOTIC TREATMENT
AB Introduction. Schizophrenia has traditionally been associated with higher rates of physical comorbidity and excess mortality.
   Objective. To develop a Spanish consensus document concerning the physical health of patients with schizophrenia and the interventions required to reduce the over-morbidity and over-mortality of these patients.
   Method. The process consisted of: G) systematic review of the literature in the Medline database up to January 2006 and manual review of the bibliographical references of the papers obtained; b) reviews of national and international guides by the coordinating committee and medical specialist acting as expert advisors; e) multidisciplinary consensus meetings, and d) editing of the final consensus document.
   Results. Compared to the general population, patients with schizophrenia present higher rates of infection (HBV, HCV, HIV), endocrine/metabolic disorders, cardiac and respiratory diseases (over-morbidity) and higher global death risk, as well as death from natural causes -basically respiratory, cardiovascular and oncological diseases (over-mortality)-. As a guide, therefore, this document proposes a series of interventions to be performed by psychiatrists to reduce the current rates.
   Conclusions. Given the over-morbidity and over-mortality of patients with schizophrenia, awareness of these aspects should be increased among primary healthcare providers and specialists, including psychiatrists, and physical health problems should be incorporated into psycho-educational programs, and treatment compliance and severe mental disorder treatment units.
C1 [Garcia-Portilla Gonzalez, M. P.] Univ Oviedo, Fac Med & Psiquiatria, E-33006 Oviedo, Spain.
   [Saiz Ruiz, J.] Univ Alcala de Henares, Madrid, Spain.
   [Vallejo Ruiloba, J.] Univ Cent Barcelona, Barcelona, Spain.
   [Giner Ubago, J.] Univ Seville, Seville, Spain.
C3 University of Oviedo; Universidad de Alcala; University of Barcelona;
   University of Sevilla
RP González, MPGP (corresponding author), Univ Oviedo, Fac Med & Psiquiatria, Julian Claveria 6, E-33006 Oviedo, Spain.
EM albert@uniovi.es
RI Ruiloba, Juana/AAA-4755-2019; Bobes, Julio/AAH-4365-2019;
   Garcia-Portilla, Paz/AAC-8272-2020; Olivares Diez, Jose
   Manuel/L-2151-2015
OI Mayoral-Cleries, Fermin/0000-0002-9710-9672; Iglesias Garcia,
   Celso/0000-0002-5064-0095; Bobes, Julio/0000-0003-2187-4033;
   Garcia-Portilla, Paz/0000-0003-3643-1622; Paramo,
   Mario/0000-0001-5165-9612; Olivares Diez, Jose
   Manuel/0000-0003-0784-9720
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NR 110
TC 59
Z9 65
U1 0
U2 15
PU JUAN JOSE LOPEZ-IBOR FOUNDATION
PI MADRID
PA NO 2, MADRID, 28035, SPAIN
SN 1139-9287
EI 1578-2735
J9 ACTAS ESP PSIQUIATRI
JI Actas Esp. Psiquiatri.
PD SEP-OCT
PY 2008
VL 36
IS 5
BP 251
EP 264
PG 14
WC Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Psychiatry
GA 370KH
UT WOS:000260760600002
PM 18830847
DA 2025-06-11
ER

PT J
AU Lam, T
   Cheema, B
   Hayden, A
   Lord, SR
   Gurney, H
   Gounden, S
   Reddy, N
   Shahidipour, H
   Read, S
   Stone, G
   McLean, M
   Birzniece, V
AF Lam, Teresa
   Cheema, Birinder
   Hayden, Amy
   Lord, Stephen R.
   Gurney, Howard
   Gounden, Shivanjini
   Reddy, Navneeta
   Shahidipour, Haleh
   Read, Scott
   Stone, Glenn
   McLean, Mark
   Birzniece, Vita
TI Androgen deprivation in prostate cancer: benefits of home-based
   resistance training
SO SPORTS MEDICINE-OPEN
LA English
DT Article
DE Progressive resistance training; Androgen deprivation therapy; Prostate
   cancer; Adverse effects
ID QUALITY-OF-LIFE; PHYSICAL-ACTIVITY; BODY-COMPOSITION; METABOLIC
   SYNDROME; FOLLOW-UP; THERAPY; EXERCISE; MEN; INSULIN; PROFESSIONALS
AB Introduction Androgen deprivation therapy (ADT) has detrimental effects on body composition, metabolic health, physical functioning, bone mineral density (BMD) and health-related quality of life (HRQOL) in men with prostate cancer. We investigated whether a 12-month home-based progressive resistance training (PRT) programme, instituted at the start of ADT, could prevent these adverse effects. Methods Twenty-five patients scheduled to receive at least 12 months of ADT were randomly assigned to either usual care (UC) (n = 12) or PRT (n = 13) starting immediately after their first ADT injection. Body composition, body cell mass (BCM; a functional component of lean body mass), BMD, physical function, insulin sensitivity and HRQOL were measured at 6 weeks and 6 and 12 months. Data were analysed by a linear mixed model. Results ADT had a negative impact on body composition, BMD, physical function, glucose metabolism and HRQOL. At 12 months, the PRT group had greater reductions in BCM by - 1.9 +/- 0.8 % (p = 0.02) and higher gains in fat mass by 3.1 +/- 1.0 % (p = 0.002), compared to the UC group. HRQOL domains were maintained or improved in the PRT versus UC group at 6 weeks (general health, p = 0.04), 6 months (vitality, p = 0.02; social functioning, p = 0.03) and 12 months (mental health, p = 0.01; vitality, p = 0.02). A significant increase in the Matsuda Index in the PRT versus UC group was noted at 6 weeks (p = 0.009) but this difference was not maintained at subsequent timepoints. Between-group differences favouring the PRT group were also noted for physical activity levels (step count) (p = 0.02). No differences in measures of BMD or physical function were detected at any time point. Conclusion A home-based PRT programme instituted at the start of ADT may counteract detrimental changes in body composition, improve physical activity and mental health over 12 months.
C1 [Lam, Teresa; Reddy, Navneeta; Shahidipour, Haleh; Read, Scott; McLean, Mark; Birzniece, Vita] Western Sydney Univ, Sch Med, Penrith, NSW, Australia.
   [Lam, Teresa] Westmead Hosp, Dept Diabet & Endocrinol, Sydney, NSW 2148, Australia.
   [Lam, Teresa; Reddy, Navneeta; Shahidipour, Haleh; Read, Scott; McLean, Mark; Birzniece, Vita] Blacktown Hosp, Dept Diabet & Endocrinol, Blacktown, NSW, Australia.
   [Cheema, Birinder; Gounden, Shivanjini] Western Sydney Univ, Sch Sci & Hlth, Penrith, NSW, Australia.
   [Hayden, Amy] Blacktown Hosp, Dept Radiat Oncol, Blacktown, NSW, Australia.
   [Hayden, Amy; Gurney, Howard] Westmead Hosp, Crown Princess Mary Canc Ctr, Sydney, NSW, Australia.
   [Lord, Stephen R.] Univ New South Wales, NeuRA, Sydney, NSW, Australia.
   [Shahidipour, Haleh; Birzniece, Vita] Univ New South Wales, Sch Med Sci, Sydney, NSW, Australia.
   [Lam, Teresa; Shahidipour, Haleh; Birzniece, Vita] Translat Hlth Res Inst, Penrith, NSW, Australia.
   [Stone, Glenn] Western Sydney Univ, Sch Comp Engn & Math, Penrith, NSW, Australia.
   [Birzniece, Vita] Garvan Inst Med Res, Sydney, NSW, Australia.
C3 Western Sydney University; NSW Health; Westmead Hospital; University of
   Sydney; NSW Health; Blacktown & Mount Druitt Hospital; Western Sydney
   University; NSW Health; Blacktown & Mount Druitt Hospital; University of
   Sydney; NSW Health; Westmead Hospital; Neuroscience Research Australia;
   University of New South Wales Sydney; University of New South Wales
   Sydney; Western Sydney University; Garvan Institute of Medical Research
RP Lam, T (corresponding author), Western Sydney Univ, Sch Med, Penrith, NSW, Australia.; Lam, T (corresponding author), Westmead Hosp, Dept Diabet & Endocrinol, Sydney, NSW 2148, Australia.; Lam, T (corresponding author), Blacktown Hosp, Dept Diabet & Endocrinol, Blacktown, NSW, Australia.
EM Teresa.Lam@health.nsw.gov.au
RI Read, Scott/K-6462-2019; Gurney, Howard/ABF-6924-2020; Lord,
   Stephen/C-9612-2011
OI Lord, Stephen R/0000-0002-7111-8802; Gurney, Howard/0000-0003-0217-5261;
   Reddy, Navneeta/0000-0002-9506-9275
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NR 47
TC 17
Z9 18
U1 2
U2 11
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 2199-1170
EI 2198-9761
J9 SPORTS MED-OPEN
JI Sports Med.-Open
PD DEC 14
PY 2020
VL 6
IS 1
AR 59
DI 10.1186/s40798-020-00288-1
PG 12
WC Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Sport Sciences
GA PG5SL
UT WOS:000599794500001
PM 33315154
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Koppold, DA
   Kandil, FI
   Güttler, O
   Müller, A
   Steckhan, N
   Meiss, S
   Breinlinger, C
   Nelle, E
   Hartmann, AM
   Jeitler, M
   Hanslian, E
   Fischer, JM
   Michalsen, A
   Kessler, CS
AF Koppold, Daniela A.
   Kandil, Farid I.
   Guettler, Oliver
   Mueller, Anna
   Steckhan, Nico
   Meiss, Sara
   Breinlinger, Carolin
   Nelle, Esther
   Hartmann, Anika M.
   Jeitler, Michael
   Hanslian, Etienne
   Fischer, Jan Moritz
   Michalsen, Andreas
   Kessler, Christian S.
TI Effects of Prolonged Fasting during Inpatient Multimodal Treatment on
   Pain and Functional Parameters in Knee and Hip Osteoarthritis: A
   Prospective Exploratory Observational Study
SO NUTRIENTS
LA English
DT Article
DE fasting; caloric restriction; osteoarthritis; dietary intervention;
   fasting-mimicking diet; integrative medicine; complementary medicine;
   traditional European medicine; nutrition; multimodal integrative
   treatment
ID RHEUMATOID-ARTHRITIS; LEECH THERAPY; METABOLIC SYNDROME; VEGETARIAN
   DIET; MOOD; MEDICINE; STRESS; TRIAL
AB Preliminary clinical data suggest that pain reduction through fasting may be effective for different diagnoses. This uncontrolled observational clinical study examined the effects of prolonged modified fasting on pain and functional parameters in hip and knee osteoarthritis. Patients admitted to the inpatient department of Internal Medicine and Nature-based Therapies of the Immanuel Hospital Berlin between February 2018 and December 2020 answered questionnaires at the beginning and end of inpatient treatment, as well as at 3, 6, and 12 months after discharge. Additionally, selected blood and anthropometric parameters, as well as subjective pain ratings, were routinely assessed during the inpatient stay. Fasting was the only common intervention for all patients, being performed as part of a multimodal integrative treatment program, with a daily caloric intake of <600 kcal for 7.7 & PLUSMN; 1.7 days. N = 125 consecutive patients were included. The results revealed an amelioration of overall symptomatology (WOMAC Index score: -14.8 & PLUSMN; 13.31; p < 0.001; d = 0.78) and pain alleviation (NRS Pain: -2.7 & PLUSMN; 1.98, p < 0.001, d = 1.48). Pain medication was reduced, stopped, or replaced by herbal remedies in 36% of patients. Improvements were also observed in secondary outcome parameters, including increased quality of life (WHO-5: +4.5 & PLUSMN; 4.94, p < 0.001, d = 0.94), reduced anxiety (HADS-A: -2.1 & PLUSMN; 2.91, p < 0001, d = 0.55) and depression (HADS-D: -2.3 & PLUSMN; 3.01, p < 0.001, d = 0.65), and decreases in body weight (-3.6 kg & PLUSMN; 1.65, p < 0.001, d = 0.21) and blood pressure (systolic: -6.2 & PLUSMN; 15.93, p < 0.001, d = 0.43; diastolic: -3.7 & PLUSMN; 10.55, p < 0.001, d = 0.43). The results suggest that patients with osteoarthritis of the lower extremities may benefit from prolonged fasting as part of a multimodal integrative treatment to improve quality of life, pain, and disease-specific functional parameters. Confirmatory randomized controlled trials are warranted to further investigate these hypotheses.
C1 [Koppold, Daniela A.; Kandil, Farid I.; Guettler, Oliver; Mueller, Anna; Steckhan, Nico; Meiss, Sara; Breinlinger, Carolin; Nelle, Esther; Hartmann, Anika M.; Jeitler, Michael; Hanslian, Etienne; Fischer, Jan Moritz; Michalsen, Andreas; Kessler, Christian S.] Univ Berlin, Univ Med Berlin Corp Member Freie, Inst Social Med Epidemiol & Hlth Econ, Charite, D-10117 Berlin, Germany.
   [Koppold, Daniela A.; Kandil, Farid I.; Guettler, Oliver; Mueller, Anna; Steckhan, Nico; Meiss, Sara; Breinlinger, Carolin; Nelle, Esther; Hartmann, Anika M.; Jeitler, Michael; Hanslian, Etienne; Fischer, Jan Moritz; Michalsen, Andreas; Kessler, Christian S.] Humboldt Univ, D-10117 Berlin, Germany.
   [Koppold, Daniela A.; Breinlinger, Carolin; Jeitler, Michael; Michalsen, Andreas; Kessler, Christian S.] Immanuel Hosp Berlin, Dept Internal Med & Nat Based Therapies, D-14109 Berlin, Germany.
   [Koppold, Daniela A.; Kandil, Farid I.] Univ Med Berlin, Corp Member Freie Univ Berlin, Charite, Dept Pediat,Div Oncol & Hematol, D-10117 Berlin, Germany.
   [Mueller, Anna] State Inst Forens Med Berlin, D-10559 Berlin, Germany.
   [Steckhan, Nico] Univ Potsdam, Hasso Plattner Inst, Connected Healthcare, D-14482 Potsdam, Germany.
   [Hartmann, Anika M.] Univ Med Berlin, Corp Member Freie Univ Berlin, Charite, Dept Dermatol Venereol & Allergol, D-10117 Berlin, Germany.
C3 Berlin Institute of Health; Free University of Berlin; Humboldt
   University of Berlin; Charite Universitatsmedizin Berlin; Humboldt
   University of Berlin; Berlin Institute of Health; Free University of
   Berlin; Humboldt University of Berlin; Charite Universitatsmedizin
   Berlin; University of Potsdam; Berlin Institute of Health; Free
   University of Berlin; Humboldt University of Berlin; Charite
   Universitatsmedizin Berlin
RP Koppold, DA (corresponding author), Univ Berlin, Univ Med Berlin Corp Member Freie, Inst Social Med Epidemiol & Hlth Econ, Charite, D-10117 Berlin, Germany.; Koppold, DA (corresponding author), Humboldt Univ, D-10117 Berlin, Germany.; Koppold, DA (corresponding author), Immanuel Hosp Berlin, Dept Internal Med & Nat Based Therapies, D-14109 Berlin, Germany.; Koppold, DA (corresponding author), Univ Med Berlin, Corp Member Freie Univ Berlin, Charite, Dept Pediat,Div Oncol & Hematol, D-10117 Berlin, Germany.
EM daniela.koppold@charite.de; farid-ihab.kandil@charite.de;
   oliver.guettler@charite.de; anna.mueller@charite.de;
   nico.steckhan@hpi.de; carolin.breinlinger@nu.uni-giessen.de;
   esther.nelle@charite.de; anika.hartmann@charite.de;
   michael.jeitler@charite.de; etienne.hanslian@charite.de;
   jan-moritz.fischer@charite.de; andreas.michalsen@immanuelalbertinen.de;
   christian.kessler@charite.de
RI Kessler, Christian/KMX-3377-2024; Hanslian, Etienne/HJI-1501-2023;
   Koppold, Daniela/HRC-4226-2023
OI Breinlinger, Carolin/0009-0000-1188-732X; Kessler,
   Christian/0000-0001-7794-8375; Rajput Khokhar,
   Anika/0000-0002-0135-9643; Hanslian, Etienne/0000-0002-8683-5011;
   Jeitler, Michael/0000-0003-3277-9090; Kandil, Farid/0000-0003-3071-7902;
   Koppold, Daniela/0000-0003-3367-3327; Fischer, Jan
   Moritz/0000-0002-3495-6495
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NR 65
TC 7
Z9 7
U1 1
U2 5
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JUN
PY 2023
VL 15
IS 12
AR 2695
DI 10.3390/nu15122695
PG 20
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA K2VK4
UT WOS:001015066200001
PM 37375597
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Kilic, A
   Yarlioglues, M
   Ercan, EA
   Duran, M
   Ugurlu, M
   Oksuz, F
   Ozdemir, S
   Kurtul, A
   Karadeniz, M
   Murat, SN
   Korkmaz, S
   Demirtas, S
AF Kilic, Alparslan
   Yarlioglues, Mikail
   Ercan, Ebru Akgul
   Duran, Mustafa
   Ugurlu, Murat
   Oksuz, Fatih
   Ozdemir, Sedat
   Kurtul, Alparslan
   Karadeniz, Muhammed
   Murat, Sani Namik
   Korkmaz, Sule
   Demirtas, Selda
TI Association of total serum antioxidant capacity with the Tei index in
   echocardiography in patients with microvascular angina
SO CORONARY ARTERY DISEASE
LA English
DT Article
DE cardiac syndrome X; Tei index; total antioxidant capacity
ID CARDIAC SYNDROME-X; NORMAL CORONARY-ARTERIES; C-REACTIVE PROTEIN;
   VASCULAR ENDOTHELIAL DYSFUNCTION; CHEST-PAIN; OXIDATIVE STRESS;
   PECTORIS; DISEASE; ARTERIOGRAMS; TISSUE
AB Objectives Cardiac syndrome X (CSX) is a condition characterized by exercise-induced chest pain that occurs considering a normal coronary angiogram. We aimed to investigate the total serum antioxidant capacity (TAC) and biventricular global functions using echocardiography in patients with CSX.
   Patients and methods The study population included 55 patients with typical anginal symptoms and a positive exercise stress test, or ischemia in myocardial perfusion scintigraphy and normal coronary arteries detected angiographically, and 49 healthy volunteers with atypical chest pain and a negative stress test. TAC was assessed from blood samples. Transthoracic echocardiography was performed for the entire study population. The Tei index was calculated using the formula IVCT + IVRT/ET.
   Results TAC was found to be significantly lower in the CSX group compared with the control group (0.70 +/- 0.37 vs. 1.5 +/- 0.30, respectively, P < 0.001). The Tei index was significantly higher in patients with CSX than the control group (0.60 +/- 0.18 vs. 0.42 +/- 0.12, respectively, P < 0.001). There was a significant and inverse relationship between TAC and the Tei index (r = -0.41, P < 0.001). When we divided the study population according to the normal range of TAC into the decreased TAC group (< 1.30 mmol/l), the normal TAC group (1.30-1.77 mmol/l), and the increased TAC group (> 1.77 mmol/l), it was found that the Tei index was higher in the decreased TAC group compared with the other groups (0.66 +/- 0.18 vs. 0.49 +/- 0.10 and 0.46 +/- 0.13 mmol/l, P < 0.001, respectively).
   Conclusion Our study suggested that TAC was significantly decreased in CSX patients and decreased antioxidant levels were related to impaired Tei index in echocardiography in patients with microvascular angina. Copyright (C) 2015 Wolters Kluwer Health, Inc. All rights reserved.
C1 [Kilic, Alparslan; Yarlioglues, Mikail; Duran, Mustafa; Oksuz, Fatih; Kurtul, Alparslan; Karadeniz, Muhammed; Murat, Sani Namik] Ankara Educ & Res Hosp, Dept Cardiol, TR-06600 Ankara, Turkey.
   [Ercan, Ebru Akgul; Ugurlu, Murat; Korkmaz, Sule] Ufuk Univ, Sch Med, Dept Cardiol, Ankara, Turkey.
   [Ozdemir, Sedat; Demirtas, Selda] Ufuk Univ, Sch Med, Dept Biochem, Ankara, Turkey.
C3 Ankara Training & Research Hospital; Ufuk University; Ufuk University
RP Kilic, A (corresponding author), Ankara Educ & Res Hosp, Dept Cardiol, TR-06600 Ankara, Turkey.
EM dr-alp@hotmail.com
RI Duran, Mustafa/ABT-9168-2022; Özdemir, Sedat/AAM-8439-2021; Yarlioglues,
   Mikail/IZD-4680-2023; Savran Karadeniz, Meltem/AAT-1165-2020; Kurtul,
   Alparslan/G-6952-2016; kilic, alparslan/ABD-9579-2022
OI Yarlioglues, Mikail/0000-0001-8905-9807
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NR 35
TC 4
Z9 4
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0954-6928
EI 1473-5830
J9 CORONARY ARTERY DIS
JI Coronary Artery Dis.
PD NOV
PY 2015
VL 26
IS 7
BP 620
EP 625
DI 10.1097/MCA.0000000000000293
PG 6
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA DD0GI
UT WOS:000369598000013
PM 26267745
DA 2025-06-11
ER

PT J
AU Peix, A
   González, A
   García, EJ
   Valiente, J
   Cabrera, LO
   Sixto, S
   Filgueiras, CE
   Cabalé, B
   Hechavarría, S
   González, I
   Carrillo, R
   García-Barreto, D
AF Peix, Amalia
   Gonzalez, Anibal
   Garcia, Ernesto J.
   Valiente, Juan
   Cabrera, Lazaro O.
   Sixto, Sherien
   Filgueiras, Cesar E.
   Cabale, Beatriz
   Hechavarria, Sheila
   Gonzalez, Iovank
   Carrillo, Regla
   Garcia-Barreto, David
TI Left Ventricular Dysfunction Secondary to Ischemia in Women with Angina
   and Normal Coronary Angiograms
SO JOURNAL OF WOMENS HEALTH
LA English
DT Article
ID CARDIAC SYNDROME-X; MYOCARDIAL-PERFUSION SPECT; ARTERY-DISEASE;
   ENDOTHELIAL DYSFUNCTION; BLOOD-FLOW; POSTSTRESS MEASUREMENTS; EJECTION
   FRACTION; PROGNOSTIC VALUE; CHEST-PAIN; PECTORIS
AB Background: Microvascular disease is proposed as a cause of segmental myocardial blood flow abnormalities and heterogeneous myocardial perfusion in cardiac syndrome X.
   Objective: To assess if myocardial ischemia can be evidenced through both perfusion abnormalities and post-stress left ventricular ejection fraction (LVEF) reduction by gated single photon emission tomography (SPECT) myocardial scintigraphy in women with syndrome X in a similar way to those with epicardial coronary lesions.
   Methods: Three groups of postmenopausal women were studied: group I, 20 women with angina, perfusion defects, and normal coronary angiography; group II, 20 women with epicardial coronary lesions (>= 50% of coronary lumen reduction); group III, 15 volunteers without signs or symptoms of ischemia (control group). Each underwent technetium- 99m ((99m)TC) methoxyisobutylisonitrile gated SPECT myocardial scintigraphy (protocol: exercise-stress-rest), brachial artery endothelial function measured by ultrasonography, and lipidogram.
   Results: Groups I and III patients had a higher body mass index (BMI). There were more smokers in groups I and II. Very low density lipoprotein cholesterol (VLDL-C) and triglycerides were higher in group II patients. The brachial artery vasodilator responsiveness after 5 minutes of ischemia was similarly lower in patients of groups I and II compared with those of group III (3% vs. 6.5%, respectively; p = 0.03 group III vs. group I and group II). Mean Delta LVEF (LVEF poststress minus LVEF at rest) was -3.86%, -2.90%, and 4.18% in groups I, II, and III, respectively (p = NS between I and II, p = 0.005 between II and III, and p = 0.003 between I and III). In 43% of group I patients and in 10 of 18 group III patients with perfusion defects, there was a poststress LVEF reduction >5%.
   Conclusions: Stress-induced ischemia is associated with poststress LVEF reduction as a probable manifestation of myocardial stunning in postmenopausal women with typical angina and normal coronary angiography.
C1 [Peix, Amalia] Inst Cardiol, Dept Nucl Med, Havana 10400, Cuba.
RP Peix, A (corresponding author), Inst Cardiol, Dept Nucl Med, Havana 10400, Cuba.
EM peix@infomed.sld.cu
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NR 37
TC 7
Z9 9
U1 0
U2 2
PU MARY ANN LIEBERT INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-9996
J9 J WOMENS HEALTH
JI J. Womens Health
PD FEB
PY 2009
VL 18
IS 2
BP 155
EP 161
DI 10.1089/jwh.2008.0844
PG 7
WC Public, Environmental & Occupational Health; Medicine, General &
   Internal; Obstetrics & Gynecology; Women's Studies
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; General & Internal
   Medicine; Obstetrics & Gynecology; Women's Studies
GA 402HE
UT WOS:000263004000004
PM 19183086
DA 2025-06-11
ER

PT J
AU Farah, R
   Jubran, F
   Khamisy-Farah, R
AF Farah, R.
   Jubran, F.
   Khamisy-Farah, R.
TI Effects of statins on oxidative stress and primed polymorphonuclear
   leukocytes in hyperlipidemic patients
SO BIOTECHNIC & HISTOCHEMISTRY
LA English
DT Article
DE apoptosis; Atrovastatin; hyperlipidemia; oxidative stress; PMNL-priming
ID DIABETIC-PATIENTS; INFLAMMATION; INVOLVEMENT; NEUTROPHILS; DISEASE
AB Inflammation and oxidative stress are among the factors that have been implicated in the pathogenesis of hyperlipidemia. In metabolic syndrome and hyperlipidemic patients, peripheral polymorphonuclear leukocytes (PMNL) are primed and they release uncontrolled superoxide that contributes to oxidative stress and inflammation. Recent studies have demonstrated that the anti-hyperlipidemic drug, Atrovastatin effects improvement in endothelial function, exhibits anti-oxidative characteristics and reduces lipid markers of oxidation. To evaluate possible nontraditional effects of treatment with Atrovastatin on PMNL priming, oxidative stress and inflammation in hyperlipidemia, 50 non-smoking hyperlipidemic patients were treated for 6 months with Atrovastatin and compared to age and gender-matched healthy controls. PMNL priming was assessed by the rate of superoxide release from separated, phorbol ester-stimulated PMNL and by PMNL-CD11b levels. Inflammation was reflected by blood inflammatory markers including albumin, transferrin, C-reactive protein (CRP) and fibrinogen levels, white blood cells (WBC), PMNL counts and PMNL apoptosis. Atrovastatin treatment showed a reduction in PMNL priming, PMNL apoptosis, fibrinogen and CRP levels concomitant with decreased lipid levels. Atrovastatin may be preferred for hyperlipidemic patients owing to its combined anti-PMNL priming and anti-inflammatory effects in addition to its anti-atherogenic effects.
C1 [Farah, R.; Jubran, F.] Ziv Med Ctr, Dept Internal Med B, Safed, Israel.
   [Khamisy-Farah, R.] Bar Ilan Univ, Fac Med, Clalit Hlth Serv, Galille, Israel.
C3 Ziv Medical Center; Bar Ilan University; Clalit Health Services
RP Farah, R (corresponding author), Ziv Med Ctr, Dept Internal Med B, Safed, Israel.
EM raymond.f@ziv.health.gov.il
RI Farah, Raymond/LWJ-6661-2024
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NR 17
TC 4
Z9 4
U1 0
U2 2
PU INFORMA HEALTHCARE
PI NEW YORK
PA 52 VANDERBILT AVE, NEW YORK, NY 10017 USA
SN 1052-0295
J9 BIOTECH HISTOCHEM
JI Biotech. Histochem.
PD NOV
PY 2012
VL 87
IS 8
BP 519
EP 525
DI 10.3109/10520295.2012.719243
PG 7
WC Biotechnology & Applied Microbiology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Cell Biology
GA 022FB
UT WOS:000309939900006
PM 22989353
DA 2025-06-11
ER

PT J
AU do Nascimento, LCP
   Lacerda, DC
   Ferreira, DJS
   de Souza, EL
   Alves, JLD
AF Paulino do Nascimento, Luciana Caroline
   Lacerda, Diego Cabral
   Soares Ferreira, Diorginis Jose
   de Souza, Evandro Leite
   de Brito Alves, Jose Luiz
TI Limosilactobacillus fermentum, Current Evidence on the
   Antioxidant Properties and Opportunities to be Exploited as a Probiotic
   Microorganism
SO PROBIOTICS AND ANTIMICROBIAL PROTEINS
LA English
DT Article
DE Probiotic; Limosilactobacillus fermentum; Oxidative stress; Antioxidant
   capacity
ID LACTOBACILLUS-FERMENTUM; OXIDATIVE STRESS; DIETARY SUPPLEMENTATION;
   FERULOYL ESTERASE; METABOLIC SYNDROME; REACTIVE OXYGEN; IN-VITRO; MODEL;
   GLUTATHIONE; PLANTARUM
AB The unbalance in the production and removal of oxygen-reactive species in the human organism leads to oxidative stress, a physiological condition commonly linked to the occurrence of cancer, neurodegenerative, inflammatory, and metabolic disorders. The implications of oxidative stress in the gut have been associated with gut microbiota impairments and gut dysbiosis. Some lactobacilli strains have shown an efficient antioxidant system capable of protecting against oxidative stress and related-chronic diseases. Recently, in vitro and experimental studies and some clinical trials have demonstrated the efficacy of the administration of various Limosilactobacillus fermentum strains to modulate beneficially the host antioxidant system resulting in the amelioration of a variety of systemic diseases phenotypes. This review presents and discusses the currently available studies on identifying L. fermentum strains with anti-oxidant properties, their sources, range of the administered doses, and duration of the intervention in experiments with animals and clinical trials. This review strives to serve as a relevant and well-cataloged reference of L. fermentum strains with capabilities of inducing anti-oxidant effects and health-promoting benefits to the host, envisaging their broad applicability to disease control.
C1 [Paulino do Nascimento, Luciana Caroline; Lacerda, Diego Cabral; de Souza, Evandro Leite; de Brito Alves, Jose Luiz] Univ Fed Paraiba, Dept Nutr, Hlth Sci Ctr, Campus 1, Joao Pessoa, Paraiba, Brazil.
   [Soares Ferreira, Diorginis Jose] Fed Univ Sao Franscisco Valley, Colegiado Educaeao Fis, Petrolina, Brazil.
C3 Universidade Federal da Paraiba
RP Alves, JLD (corresponding author), Univ Fed Paraiba, Dept Nutr, Hlth Sci Ctr, Campus 1, Joao Pessoa, Paraiba, Brazil.
EM jose_luiz_61@hotmail.com
RI Lacerda, Diego/GOV-3252-2022; De Brito Alves, José/R-7175-2017; de
   Souza, Evandro/E-8851-2017
OI de Souza, Evandro/0000-0003-4927-9383; de Brito Alves, Jose
   Luiz/0000-0003-4696-3809
FU Fundacao de Apoio a Pesquisa do Estado da Paraiba (FAPESQ, Brazil);
   Brazilian National Council for Scientific and Technological Development
   (CNPq)
FX The authors are grateful to the Fundacao de Apoio a Pesquisa do Estado
   da Paraiba (FAPESQ, Brazil) for the scholarships awarded to L.C.P.d. N
   and D.C.L. Additionally, the authors give thanks for the research
   productivity fellowship granted by the Brazilian National Council for
   Scientific and Technological Development (CNPq) to J.L.d.B.A and E.L.d.
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NR 108
TC 31
Z9 32
U1 7
U2 43
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1867-1306
EI 1867-1314
J9 PROBIOTICS ANTIMICRO
JI Probiotics Antimicrob. Proteins
PD OCT
PY 2022
VL 14
IS 5
BP 960
EP 979
DI 10.1007/s12602-022-09943-3
EA APR 2022
PG 20
WC Biotechnology & Applied Microbiology; Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Microbiology
GA 4N2UI
UT WOS:000787124500001
PM 35467236
DA 2025-06-11
ER

PT J
AU Aloui, F
   Charradi, K
   Hichami, A
   Subramaniam, S
   Khan, NA
   Limam, F
   Aouani, E
AF Aloui, Faten
   Charradi, Kamel
   Hichami, Aziz
   Subramaniam, Selvakumar
   Khan, Naim Akhtar
   Limam, Ferid
   Aouani, Ezzedine
TI Grape seed and skin extract reduces pancreas lipotoxicity, oxidative
   stress and inflammation in high fat diet fed rats
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Article
DE Obesity; Pancreas; Grape seed and skin extract; Oxidative stress;
   Inflammation
ID INDUCED DIABETIC-RATS; LIPID-ACCUMULATION; ISLET INFLAMMATION; METABOLIC
   SYNDROME; ZINC-DEFICIENCY; ADIPOSE-TISSUE; RESVERATROL; POLYPHENOLS;
   DISEASE; SERUM
AB Obesity is related to an elevated risk of diabetes and the mechanisms whereby fat adversely affects the pancreas are poorly understood. We studied the effect of a high fat diet (HFD) on pancreas steatosis, oxidative stress and inflammation as well as the putative protection afforded by grape seed and skin extract (GSSE). HFD induced body weight gain, without affecting insulinemia, nor glycemia and dropped adiponectemia. HFD also provoked the ectopic deposition of cholesterol and triglyceride, and an oxidative stress characterized by increased lipoperoxidation and carbonylation, inhibition of antioxidant enzyme activities such as CAT, GPx and SOD, depletion of zinc and a concomitant increase in calcium and H2O2. HFD induced pro-inflammatory chemokines mRNA as RANTES and MCP1 as well as cytokines expression as TNF alpha, IL6 and IL1 beta. Importantly GSSE counteracted all the deleterious effects of HFD on pancreas in vivo i-e lipotoxicity, oxidative stress and inflammation.
   In conclusion, GSSE could find potential applications in fat-induced pancreas lipotoxicity and dysfunction. (C) 2016 Elsevier Masson SAS. All rights reserved.
C1 [Aloui, Faten; Charradi, Kamel; Aouani, Ezzedine] Univ Carthage, Fac Sci Bizerte, Jarzouna 7021, Tunisia.
   [Aloui, Faten; Charradi, Kamel; Limam, Ferid; Aouani, Ezzedine] Ctr Biotechnol Borj Cedria, Lab Subst Bioact LSBA, BP-901, Hammam Lif 2050, Tunisia.
   [Hichami, Aziz; Subramaniam, Selvakumar; Khan, Naim Akhtar] Univ Bourgogne, INSERM, UMR U866, Physiol Nutr & Toxicol,Agrosup, 6,Blvd Gabriel, F-21000 Dijon, France.
C3 Universite de Carthage; Centre de Biotechnologie de Borj Cedria;
   Universite Bourgogne Europe; Institut Agro; AgroSup Dijon; Institut
   National de la Sante et de la Recherche Medicale (Inserm)
RP Charradi, K (corresponding author), Ctr Biotechnol Borj Cedria, Lab Subst Bioact LSBA, BP-901, Hammam Lif 2050, Tunisia.
EM charradi3@yahoo.com
RI Hichami, Aziz/MCJ-2247-2025; aloui, foued/LVR-0740-2024; Charradi,
   Kamel/AAR-8778-2021; Subramaniam, Selvakumar/AAI-2163-2020
OI Selvakumar, Subramaniam/0000-0001-9471-7632; Khan, Naim
   Akhtar/0000-0002-8930-9332
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NR 57
TC 26
Z9 27
U1 0
U2 22
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD DEC
PY 2016
VL 84
BP 2020
EP 2028
DI 10.1016/j.biopha.2016.11.017
PG 9
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA EF6JU
UT WOS:000390438100240
PM 27847215
DA 2025-06-11
ER

PT J
AU Ju, H
   Kang, E
   Kim, Y
   Ko, H
   Cho, B
AF Ju, HyoRim
   Kang, EunKyo
   Kim, YoungIn
   Ko, HyunYoung
   Cho, Belong
TI The Effectiveness of a Mobile Health Care App and Human Coaching Program
   in Primary Care Clinics: Pilot Multicenter Real-World Study
SO JMIR MHEALTH AND UHEALTH
LA English
DT Article
DE healthcare; health care; mobile application; app; self-management;
   primary care; chronic conditions
AB Background: As the global burden of chronic conditions increases, their effective management is a concern. Although the need for chronic disease management using mobile self-management health care apps is increasing, there are still many barriers to their practical application in the primary care field.
   Objective: This study evaluated the effectiveness of primary care services combining a mobile self-management health care app with human coaching for patients with chronic diseases in the current primary care system.
   Methods: A total of 110 patients (mean age 53.2, SD 9.2 years; 64 of 110, 58.2% female) with hypertension, diabetes, dyslipidemia, or metabolic syndrome who visited one of 17 participating primary care clinics from September to November 2020 were included in this study. All participants recorded data regarding changes in body weight, sleep conditions, quality of life, depression, anxiety, stress, BMI, waist circumference, blood sugar levels, blood pressure, and blood lipids levels. The app user group (n=65) used a mobile self-management health care app with human coaching for 12 weeks, and the control group (n=45) underwent conventional self-managed health care.
   Results: Patients in the app user group reported significantly more weight loss than those in the control group-the body weight of the app user group decreased by 1.43 kg (95% CI -2.07 to -0.79) and that of the control group decreased by 0.13 kg (95% CI -0.67 to 0.41; P=.002). The weight loss was markedly greater after using the app for 9 weeks than that when used for 4 weeks or 5-8 weeks (P=.002). Patients in the app user group reported better sleep quality (P=.04) and duration (P=.004) than those in the control group.
   Conclusions: The combination of primary care clinics and a mobile self-management health care app with human coaching results in better management of chronic conditions. This study shows that the primary care services combining a mobile self-management health care app with human coaching are effective in the current primary care system. An implication of this study is the possibility that a mobile self-management health care app with human coaching is a treatment option in the current primary care system.
C1 [Ju, HyoRim; Cho, Belong] Seoul Natl Univ Hosp, Dept Family Med, 101 Daehangno, Seoul 03080, South Korea.
   [Kang, EunKyo] Natl Canc Ctr, Natl Canc Control Inst, Goyang, South Korea.
   [Kim, YoungIn; Ko, HyunYoung] Noom Inc, Noom Korea, Seoul, South Korea.
C3 Seoul National University (SNU); Seoul National University Hospital;
   National Cancer Center - Korea (NCC)
RP Cho, B (corresponding author), Seoul Natl Univ Hosp, Dept Family Med, 101 Daehangno, Seoul 03080, South Korea.
EM belong@snu.ac.kr
RI Cho, Belong/GLU-3443-2022
OI Ju, HyoRim/0000-0002-5122-8932; Kang, EunKyo/0000-0001-5844-5625; Cho,
   Belong/0000-0001-9558-689X; Ko, Hyunyoung/0000-0002-0791-1208
FU Korea Health Technology R&D Project through the Korea Health Industry
   Development Institute - Ministry of Health & Welfare, Republic of Korea
   [Nutrition-2020-70]; Korea Health Industry Development Institute
   [Nutrition-2020-70]
FX This research was supported by a grant of the Korea Health Technology
   R&D Project through the Korea Health Industry Development Institute,
   funded by the Ministry of Health & Welfare, Republic of Korea (grant
   Nutrition-2020-70) . Noom conducted this research and provided
   applications for this research. We thank Noom?s coaches for their
   dedicated contributions. Noom?s employees, except for YK and HK, had no
   role in the management, analysis, and interpretation of the data;
   preparation, review,or approval of the manuscript; and decision to
   submit the manuscript for publication. This study was supported by the
   Korea Health Industry Development Institute (grant Nutrition-2020-70) .
CR [Anonymous], 2022, JMIR MHEALTH UHEALTH, V10, DOI 10.2196/34531
   [Anonymous], 2022, JMIR MHEALTH UHEALTH
   Ju H., 2022, JMIR MHealth UHealth
NR 3
TC 6
Z9 6
U1 0
U2 13
PU JMIR PUBLICATIONS, INC
PI TORONTO
PA 130 QUEENS QUAY East, Unit 1100, TORONTO, ON M5A 0P6, CANADA
SN 2291-5222
J9 JMIR MHEALTH UHEALTH
JI JMIR mHealth uHealth
PD MAY
PY 2022
VL 10
IS 5
AR e34531
DI 10.2196/34531
PG 11
WC Health Care Sciences & Services; Medical Informatics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Health Care Sciences & Services; Medical Informatics
GA 3L2ZR
UT WOS:000834634900008
PM 35522461
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Jarczok, MN
   Jarczok, M
   Mauss, D
   Koenig, J
   Li, J
   Herr, RM
   Thayer, JF
AF Jarczok, Marc N.
   Jarczok, Marion
   Mauss, Daniel
   Koenig, Julian
   Li, Jian
   Herr, Raphael M.
   Thayer, Julian F.
TI Autonomic nervous system activity and workplace stressors-A systematic
   review
SO NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
LA English
DT Review
DE Stress; Psychosocial strain; Employees; Heart rate variability; Vagal
   tone; Psychosocial work environment
ID HEART-RATE-VARIABILITY; EFFORT-REWARD IMBALANCE; AMBULATORY
   BLOOD-PRESSURE; VAGAL CARDIAC CONTROL; WORK STRESS; ORGANIZATIONAL
   JUSTICE; METABOLIC SYNDROME; NEURAL REGULATION; JOB STRAIN; DISEASE
AB Aim: This systematic review evaluates and summarizes the evidence of the association between psychosocial work environment as indicated by several work-stress models such as Job-Demand-Control (JDC), Effort-Reward-Imbalance (ERI), or Organizational Justice (OJ) and autonomic nervous system (ANS) function as indexed by heart rate variability (HRV).
   Method: We conducted a systematic literature search following the PRISMA-Statement in eleven databases including Medline, Web of Science and PsycINFO to address medical as well as psychological aspects of the relation between psychosocial work-stress models and HRV.
   Results: We identified 19 publications with a total of 8382 employees from ten countries reporting data from the years 1976-2008. Overall, nine of all studies report a negative and significant association between vagally-mediated HRV and measures of stress at work, while eight of all studies report a negative and significant association to mixed sympathetic and parasympathetic measures of HRV.
   Conclusions: This systematic review provides evidence that adverse psychosocial work conditions are negatively associated with ANS function as indexed by HRV. (C) 2013 Elsevier Ltd. All rights reserved.
C1 [Jarczok, Marc N.; Jarczok, Marion; Herr, Raphael M.] Heidelberg Univ, Mannheim Med Fac, Mannheim Inst Publ Hlth Social & Prevent Med, D-68167 Mannheim, Germany.
   [Jarczok, Marion; Herr, Raphael M.] Univ Amsterdam, Dept Clin Psychol, NL-1018 XA Amsterdam, Netherlands.
   [Mauss, Daniel] Allianz Germany, Dept Occupat Med, D-80802 Munich, Germany.
   [Koenig, Julian] SRH Univ, Sch Therapeut Sci, D-69123 Heidelberg, Germany.
   [Li, Jian] Univ Dusseldorf, Fac Med, Inst Occupat & Social Med, D-40225 Dusseldorf, Germany.
   [Thayer, Julian F.] Ohio State Univ, Dept Psychol, Columbus, OH 43210 USA.
C3 Ruprecht Karls University Heidelberg; University of Amsterdam; Allianz
   SE; Heinrich Heine University Dusseldorf; University System of Ohio;
   Ohio State University
RP Jarczok, MN (corresponding author), Heidelberg Univ, Mannheim Med Fac, Mannheim Inst Publ Hlth Social & Prevent Med, Ludolf Krehl Str 7-11, D-68167 Mannheim, Germany.
EM Marc.Jarczok@gmail.com; Marion.jarczok@gmail.com;
   Daniel.mauss@allianz.de; Julian.koenig@fh-heidelberg.de;
   Lijian1974@hotmail.com; Raphael.herr@medma.uni-heidelberg.de;
   Thayer@psy.ohio-state.edu
RI Herr, Raphael/GYU-5115-2022; Thayer, Julian/AAA-1161-2020; Jarczok,
   Marion/NFT-1717-2025; Jarczok, Marc N./A-2383-2014; Koenig,
   Julian/J-8863-2017
OI Jarczok, Marc N./0000-0002-6055-385X; Koenig, Julian/0000-0003-1009-9625
FU Humboldt Senior Research Award
FX Julian F. Thayer was supported by a Humboldt Senior Research Award.
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NR 67
TC 158
Z9 171
U1 1
U2 85
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0149-7634
EI 1873-7528
J9 NEUROSCI BIOBEHAV R
JI Neurosci. Biobehav. Rev.
PD SEP
PY 2013
VL 37
IS 8
BP 1810
EP 1823
DI 10.1016/j.neubiorev.2013.07.004
PG 14
WC Behavioral Sciences; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Behavioral Sciences; Neurosciences & Neurology
GA 251BK
UT WOS:000326902600037
PM 23891906
DA 2025-06-11
ER

PT J
AU Obaya, HE
   Abdeen, HA
   Salem, AA
   Shehata, MA
   Aldhahi, MI
   Muka, T
   Marques-Sule, E
   Taha, MM
   Gaber, M
   Atef, H
AF Obaya, Hany Ezzat
   Abdeen, Heba Ahmed
   Salem, Alae Ahmed
   Shehata, Mai Ali
   Aldhahi, Monira I.
   Muka, Taulant
   Marques-Sule, Elena
   Taha, Mona Mohamed
   Gaber, Marwa
   Atef, Hady
TI Effect of aerobic exercise, slow deep breathing and mindfulness
   meditation on cortisol and glucose levels in women with type 2 diabetes
   mellitus: a randomized controlled trial
SO FRONTIERS IN PHYSIOLOGY
LA English
DT Article
DE aerobic training; breathing exercise; mindfulness meditation; serum
   cortisol concentrations; glucose
ID STRESS; RISK; METAANALYSIS; ANXIETY; DISEASE; HEALTH; AXIS
AB Background: Aerobic exercise combined with breathing exercise can be an integral part of diabetes mellitus treatment. This single-center, randomized, parallel-group study investigated the effect of the combination of aerobic exercise with slow deep breathing and mindfulness meditation on the glucose and cortisol levels of women with type 2 diabetes mellitus (T2DM).
   Materials and Methods: Fifty-eight middle-aged women with T2DM (mean age: 45.67 +/- 2.92 years) were randomly assigned to either the aerobic training group (AT: n = 29; mean age [46.1 +/- 2.7 years]) or the aerobic exercise combined with slow deep breathing and mindfulness meditation (AT + DMM: n = 29; mean age [45.24 +/- 3.14 years]). Aerobic exercise was performed at 60%-75% of the maximum heart rate. The women in each group were asked to perform the training three times weekly over a 6-week period. The duration of each session was 40 min for the AT group and 60 min for the AT + DMM group. The two groups were asked to perform aerobic exercise at 60%-75% of the maximum heart rate. Their fasting blood glucose (FBG) and serum cortisol levels were measured at the baseline and after the 6 weeks.
   Results: Compared with the AT group, the group undertaking 6 weeks of aerobic training combined with slow, deep breathing exercises and mindfulness meditation showed significantly lower levels of FBG (p = 0.001) and cortisol levels (p = 0.01) than the AT group.
   Conclusion: The addition of slow deep breathing and mindfulness meditation to aerobic exercise can better control the glucose and cortisol levels of women with T2DMand thereby improve their outcomes and decrease their cardiometabolic risk.
C1 [Obaya, Hany Ezzat; Abdeen, Heba Ahmed; Atef, Hady] Cairo Univ, Fac Phys Therapy, Dept Phys Therapy Cardiovasc Resp Disorder & Geria, Giza, Egypt.
   [Salem, Alae Ahmed] Cairo Univ, OutpatientsClin Fac Phys Therapy, Giza, Egypt.
   [Shehata, Mai Ali] Cairo Univ, Fac Phys Therapy, Dept Phys Therapy Womens Hlth, Giza, Egypt.
   [Aldhahi, Monira I.; Taha, Mona Mohamed] Princess Nourah bint Abdulrahman Univ, Coll Hlth & Rehabil Sci, Dept Rehabil Sci, Riyadh, Saudi Arabia.
   [Muka, Taulant] Univ Bern, Inst Social & Prevent Med ISPM, Bern, Switzerland.
   [Muka, Taulant] Epistudia, Bern, Switzerland.
   [Marques-Sule, Elena] Univ Valencia, Fac Physiotherapy, Dept Physiotherapy, Physiotherapy Mot,Multispecialty Res Grp, Valencia, Spain.
   [Gaber, Marwa] Alexandria Univ, Med Res Inst, Alexandria, Egypt.
   [Atef, Hady] Keele Univ, Sch Allied Hlth Profess, Keele, Staffs, England.
C3 Egyptian Knowledge Bank (EKB); Cairo University; Egyptian Knowledge Bank
   (EKB); Cairo University; Egyptian Knowledge Bank (EKB); Cairo
   University; Princess Nourah bint Abdulrahman University; University of
   Bern; University of Valencia; Egyptian Knowledge Bank (EKB); Alexandria
   University; Keele University
RP Aldhahi, MI (corresponding author), Princess Nourah bint Abdulrahman Univ, Coll Hlth & Rehabil Sci, Dept Rehabil Sci, Riyadh, Saudi Arabia.
EM mialdhahi@pnu.edu.sa
RI Taha, Mona/GRJ-1326-2022; Abdeen, Heba/AAV-2954-2021; Aldhahi,
   Monira/ABF-6238-2021
OI atef, hady/0000-0002-3089-2674; Aldhahi, Monira/0000-0002-5255-4860;
   Marques Sule, Elena/0000-0001-8554-5402
FU Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia
   [PNURSP2023R286]
FX & nbsp;This research was funded by Princess Nourah bint Abdulrahman
   University Researchers Supporting Project number (PNURSP2023R286),
   Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia.
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NR 41
TC 6
Z9 7
U1 6
U2 21
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1664-042X
J9 FRONT PHYSIOL
JI Front. Physiol.
PD JUL 13
PY 2023
VL 14
AR 1186546
DI 10.3389/fphys.2023.1186546
PG 8
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA N6QQ4
UT WOS:001038238000001
PM 37520826
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Yadav, DMD
   Muralidhar, MN
   Prasad, SMVK
   Rao, KR
AF Yadav, D. M. Dinesh
   Muralidhar, M. N.
   Prasad, S. M. V. K.
   Rao, K. Rajender
TI Pre-pubertal diet restriction reduces reactive oxygen species and
   restores fertility in male WNIN/Obese rat
SO ANDROLOGIA
LA English
DT Article
DE diet restriction; male fertility; obesity; oxidative stress; WNIN; Ob
ID BODY-MASS INDEX; MILD CALORIE RESTRICTION; OXIDATIVE STRESS; METABOLIC
   SYNDROME; TESTOSTERONE PROPIONATE; REPRODUCTIVE HORMONES; INFERTILE
   PATIENTS; DIABETES-MELLITUS; PLASMA PARAMETERS; GENE-EXPRESSION
AB Obesity is a multifactorial disorder associated with increased body adiposity, chronic oxidative stress which contributes to impaired fertility in males. Diet restriction and anti-oxidant supplementations are known to protect obese subjects from oxidative stress and improves fertility. However, the role of oxidative stress and the age of intervention in restoring male fertility are poorly understood. This study was aimed to assess the effect of diet restriction on fertility with respect to the age of intervention, body composition and oxidative stress using WNIN/Ob obese mutant rat strain. Unlike lean and carrier phenotypes, obese rats are hyperphagic, hyperlipaemic and infertile. Male obese rats aged for 35, 60 and 90days were fed either ad libitum or diet restricted for 6weeks. Upon diet restriction mean body weight, total body fat percentage, circulatory lipids and oxidative stress markers were significantly reduced and it follows the order as 35<60<90days. Diet-restricted males of the three age groups were allowed to mate with female carrier rats, and fertility was restored only in 35-day group. Diet restriction in male obese WNIN/Ob rats lowered the rate of body weight gain, with reduced oxidative stress overall and fertility restoration in groups intervened at pre-pubertal stages.
C1 [Yadav, D. M. Dinesh; Muralidhar, M. N.; Prasad, S. M. V. K.; Rao, K. Rajender] Natl Inst Nutr, Mol Genet, Natl Ctr Lab Anim Sci, Hyderabad, Telangana, India.
C3 Indian Council of Medical Research (ICMR); ICMR - National Animal
   Resource Facility for Biomedical Research (NARFBR); ICMR - National
   Institute of Nutrition (NIN)
RP Rao, KR (corresponding author), Natl Inst Nutr ICMR, Natl Ctr Lab Anim Sci, Hyderabad, Telangana, India.
EM rkrajender@yahoo.com
RI yadav, dinkar/AAD-6322-2019
OI Prasad, SMVK/0000-0003-3300-9215; Yadav, Dinesh/0000-0002-8843-3016
FU National Institute of Nutrition-ICMR, Intramural grants [11-NC02]
FX This work was supported by National Institute of Nutrition-ICMR,
   Intramural grants No. 11-NC02
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NR 58
TC 6
Z9 6
U1 0
U2 13
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0303-4569
EI 1439-0272
J9 ANDROLOGIA
JI Andrologia
PD MAR
PY 2018
VL 50
IS 2
AR e12849
DI 10.1111/and.12849
PG 7
WC Andrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA FW0PS
UT WOS:000424997800012
PM 28718974
DA 2025-06-11
ER

PT S
AU Batista, TM
   da Silva, PMR
   Amaral, AG
   Ribeiro, RA
   Boschero, AC
   Carneiro, EM
AF Batista, Thiago Martins
   Ribeiro da Silva, Priscilla Muniz
   Amaral, Andressa Godoy
   Ribeiro, Rosane Aparecida
   Boschero, Antonio Carlos
   Carneiro, Everardo Magalhaes
BE ElIdrissi, A
   LAmoreaux, WJ
TI Taurine Supplementation Restores Insulin Secretion and Reduces ER Stress
   Markers in Protein-Malnourished Mice
SO TAURINE 8, VOL 2: NUTRITION AND METABOLISM, PROTECTIVE ROLE, AND ROLE IN
   REPRODUCTION, DEVELOPMENT, AND DIFFERENTIATION
SE Advances in Experimental Medicine and Biology
LA English
DT Article; Proceedings Paper
CT 18th International Taurine Meeting
CY APR 07-13, 2012
CL Marrakesh, MOROCCO
SP Taisho Pharmaceut Co Ltd
ID ENDOPLASMIC-RETICULUM STRESS; PANCREATIC-ISLETS; LEUCINE
   SUPPLEMENTATION; GLUCOSE-HOMEOSTASIS; DIABETES-MELLITUS; RATS; DIET;
   EXPRESSION; DISEASE; OBESITY
AB Endoplasmic reticulum (ER) stress is a cellular response to increased intra-reticular protein accumulation or poor ER function. Chronic activation of this pathway may lead to beta cell death and metabolic syndrome (MS). Poor nutrition during perinatal period, especially protein malnutrition, is associated with increased risk for MS in later life. Here, we analyzed the effects of taurine (TAU) supplementation upon insulin secretion and ER stress marker expression in pancreatic islets and in the liver from mice fed a low-protein diet. Malnourished mice had lower body weight and plasma insulin. Their islets secreted less insulin in response to stimulatory concentrations of glucose. TAU supplementation increased insulin secretion in both normal protein and malnourished mice. Western blot analysis revealed lower expression of the ER stress markers CHOP and ATF4 and increased phosphorylation of the survival protein Akt in pancreatic islets of TAU-supplemented mice. The phosphorylation of the mitogenic protein extracellular signal-regulated kinase (ERK1/2) was increased after acute incubation with TAU. Finally, the ER stress markers p-PERK and BIP were increased in the liver of malnourished mice and TAU supplementation normalized these parameters.
   In conclusion, malnutrition leads to impaired islet function which is restored with TAU supplementation possibly by increasing survival signals and lowering ER stress proteins. Lower ER stress markers in the liver may also contribute to the improvement of insulin action on peripheral organs.
C1 [Batista, Thiago Martins; Ribeiro da Silva, Priscilla Muniz; Boschero, Antonio Carlos; Carneiro, Everardo Magalhaes] Univ Estadual Campinas, Inst Biol, Dept Biol Func & Estrutural, BR-13081970 Campinas, SP, Brazil.
   [Amaral, Andressa Godoy] Univ Sao Paulo, Div Nefrol & Med Mol, Sao Paulo, Brazil.
   [Ribeiro, Rosane Aparecida] UFRJ, Nucleo Ecol & Desenvolvimento Socioambiental Maca, Macae, RJ, Brazil.
C3 Universidade Estadual de Campinas; Universidade de Sao Paulo;
   Universidade Federal do Rio de Janeiro
RP Batista, TM (corresponding author), Univ Estadual Campinas, Inst Biol, Dept Biol Func & Estrutural, BR-13081970 Campinas, SP, Brazil.
EM thiagombatista@yahoo.com.br
RI Ribeiro, Rosane/C-2180-2013; Silva, Priscilla/C-3515-2014; Boschero,
   Antonio/O-7525-2014; Carneiro, Everardo/D-4758-2012; AMARAL,
   ANDRESSA/E-8212-2018; Batista, Thiago M./C-9816-2014; GODOY AMARAL,
   ANDRESSA/O-1821-2015
OI Batista, Thiago M./0000-0001-6971-1191; GODOY AMARAL,
   ANDRESSA/0000-0002-1261-2982; Magalhaes Carneiro,
   Everardo/0000-0003-3212-369X
FU Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP); Conselho
   Nacional para o Desenvolvimento Cientfico e Tecnologico (CNPq);
   Instituto Nacional de Ciencia e Tecnologia (INCT)
FX This study was supported by grants from Fundacao de Amparo a Pesquisa do
   Estado de Sao Paulo (FAPESP), Conselho Nacional para o Desenvolvimento
   Cientfico e Tecnologico (CNPq), and Instituto Nacional de Ciencia e
   Tecnologia (INCT).
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NR 34
TC 24
Z9 26
U1 0
U2 2
PU SPRINGER
PI NEW YORK
PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES
SN 0065-2598
EI 2214-8019
BN 978-1-4614-6093-0; 978-1-4614-6092-3
J9 ADV EXP MED BIOL
JI Adv.Exp.Med.Biol.
PY 2013
VL 776
BP 129
EP 139
DI 10.1007/978-1-4614-6093-0_14
PG 11
WC Biochemical Research Methods; Biochemistry & Molecular Biology;
   Medicine, Research & Experimental; Nutrition & Dietetics
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Research & Experimental Medicine;
   Nutrition & Dietetics
GA BA5XW
UT WOS:000337057500014
PM 23392878
DA 2025-06-11
ER

PT J
AU George, SA
   Khan, S
   Briggs, H
   Abelson, JL
AF George, Sophie A.
   Khan, Samir
   Briggs, Hedieh
   Abelson, James L.
TI CRH-stimulated cortisol release and food intake in healthy, non-obese
   adults
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE Stress; Cortisol; CRH; Appetite; HPA
ID STRESS-INDUCED CORTISOL; PITUITARY-ADRENAL AXIS; BODY-FAT DISTRIBUTION;
   EATING BEHAVIOR; DAILY HASSLES; METABOLIC SYNDROME; WOMEN;
   GLUCOCORTICOIDS; CORTICOSTERONE; SECRETION
AB Background: There is considerable anecdotal and some scientific evidence that stress triggers eating behavior, but underlying physiological mechanisms remain uncertain. The hypothalamic-pituitary-adrenal (HPA) axis is a key mediator of physiological stress responses and may play a role in the link between stress and food intake. Cortisol responses to laboratory stressors predict consumption but it is unclear whether such responses mark a vulnerability to stress-related eating or whether cortisol directly stimulates eating in humans.
   Methods: We infused healthy adults with corticotropin-releasing hormone (CRH) at a dose that is subjectively undetectable but elicits a robust endogenous cortisol response, and measured subsequent intake of snack foods, allowing analysis of HPA reactivity effects on food intake without the complex psychological effects of a stress paradigm.
   Results: CRH elevated cortisol levels relative to placebo but did not impact subjective anxious distress. Subjects ate more following CRH than following placebo and peak cortisol response to CRH was strongly related to both caloric intake and total consumption.
   Conclusions: These data show that HPA axis reactivity to pharmacological stimulation predicts subsequent food intake and suggest that cortisol itself may directly stimulate food consumption in humans. Understanding the physiological mechanisms that underlie stress-related eating may prove useful in efforts to attack the public health crises created by obesity. (C) 2009 Elsevier Ltd. All rights reserved.
C1 [George, Sophie A.; Khan, Samir; Briggs, Hedieh; Abelson, James L.] Univ Michigan, Dept Psychiat, Trauma Stress & Anxiety Res Grp, Ann Arbor, MI 48109 USA.
C3 University of Michigan System; University of Michigan
RP Abelson, JL (corresponding author), Univ Michigan, Dept Psychiat, Trauma Stress & Anxiety Res Grp, 4250 Plymouth Rd,Box 5765, Ann Arbor, MI 48109 USA.
EM jabelson@umich.edu
FU National Institute of Mental Health [ROI MH052724]; National Institute
   of Health General Clinical Research Center [M01-RR000042]
FX This work was supported by the National Institute of Mental Health (ROI
   MH052724) and a National Institute of Health General Clinical Research
   Center grant (M01-RR000042). NIH/NIMH had no role in the study design;
   in the collection, analysis and interpretation of data; in the writing
   of the report; or in the decision to submit for publication.
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NR 31
TC 98
Z9 117
U1 2
U2 24
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD MAY
PY 2010
VL 35
IS 4
BP 607
EP 612
DI 10.1016/j.psyneuen.2009.09.017
PG 6
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA 590JS
UT WOS:000277222300013
PM 19828258
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Monickaraj, F
   Aravind, S
   Nandhini, P
   Prabu, P
   Sathishkumar, C
   Mohan, V
   Balasubramanyam, M
AF Monickaraj, Finny
   Aravind, Sankaramoorthy
   Nandhini, Pichamoorthy
   Prabu, Paramasivam
   Sathishkumar, Chandrakumar
   Mohan, Viswanathan
   Balasubramanyam, Muthuswamy
TI Accelerated fat cell aging links oxidative stress and insulin resistance
   in adipocytes
SO JOURNAL OF BIOSCIENCES
LA English
DT Article
DE Adipocytes; insulin resistance; oxidative stress; p53; senescence
ID ASYMMETRIC DIMETHYLARGININE; ADIPOSE-TISSUE; DNA-DAMAGE; METABOLIC
   SYNDROME; PREMATURE DEATH; SENESCENCE; OVEREXPRESSION; PATHWAY; OBESITY;
   MICE
AB Telomere shortening is emerging as a biological indicator of accelerated aging and aging-related diseases including type 2 diabetes. While telomere length measurements were largely done in white blood cells, there is lack of studies on telomere length in relation to oxidative stress in target tissues affected in diabetes. Therefore, the aim of this study is to induct oxidative stress in adipocytes and to test whether these adipocytes exhibit shortened telomeres, senescence and functional impairment. 3T3-L1 adipocytes were subjected to oxidative stress and senescence induction by a variety of means for 2 weeks (exogenous application of H2O2, glucose oxidase, asymmetric dimethylarginine (ADMA) and glucose oscillations). Cells were probed for reactive oxygen species generation (ROS), DNA damage, mRNA and protein expression of senescent and pro-inflammatory markers, telomere length and glucose uptake. Compared to untreated cells, both ROS generation and DNA damage were significantly higher in cells subjected to oxidative stress and senescence. Adipocytes subjected to oxidative stress also showed shortened telomeres and increased mRNA and protein expression of p53, p21, TNF alpha and IL-6. Senescent cells were also characterized by decreased levels of adiponectin and impaired glucose uptake. Briefly, adipocytes under oxidative stress exhibited increased ROS generation, DNA damage, shortened telomeres and switched to senescent/pro-inflammatory phenotype with impaired glucose uptake.
C1 [Balasubramanyam, Muthuswamy] Madras Diabet Res Fdn, Madras 600086, Tamil Nadu, India.
   IDF Ctr Educ, Dr Mohans Diabet Special Ctr, WHO Collaborating Ctr Noncommunicable Dis Prevent, Madras 600086, Tamil Nadu, India.
C3 Madras Diabetes Research Foundation
RP Balasubramanyam, M (corresponding author), Madras Diabet Res Fdn, Madras 600086, Tamil Nadu, India.
EM balusignal@gmail.com
RI Prabu, Paramasivam/V-8323-2018; Viswanathan, Mohan/C-2321-2009; Prabu,
   Paramasivam/HPE-3307-2023; Chandrakumar, Sathishkumar/AAM-3149-2020
OI Sankaramoorthy, Aravind/0009-0001-2989-199X; Prabu,
   Paramasivam/0000-0002-8626-1601; Chandrakumar,
   Sathishkumar/0000-0003-2320-050X; Mohan, Viswanathan/0000-0001-5038-6210
FU Department of Biotechnology (DBT), India; Council of Scientific and
   Industrial Research (CSIR), India
FX The present work was supported by a grant from the Department of
   Biotechnology (DBT), India. Financial assistance through Senior Research
   Fellowship by the Council of Scientific and Industrial Research (CSIR),
   India, is also acknowledged.
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NR 38
TC 49
Z9 58
U1 0
U2 18
PU INDIAN ACAD SCIENCES
PI BANGALORE
PA C V RAMAN AVENUE, SADASHIVANAGAR, P B #8005, BANGALORE 560 080, INDIA
SN 0250-5991
EI 0973-7138
J9 J BIOSCIENCES
JI J. Biosci.
PD MAR
PY 2013
VL 38
IS 1
BP 113
EP 122
DI 10.1007/s12038-012-9289-0
PG 10
WC Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics
GA 087GK
UT WOS:000314749100015
PM 23385819
DA 2025-06-11
ER

PT J
AU Xu, SJ
   Xi, JQ
   Wu, T
   Wang, ZL
AF Xu, Shengjie
   Xi, Jiaqiu
   Wu, Tao
   Wang, Zhonglin
TI The Role of Adipocyte Endoplasmic Reticulum Stress in Obese Adipose
   Tissue Dysfunction: A Review
SO INTERNATIONAL JOURNAL OF GENERAL MEDICINE
LA English
DT Review
DE endoplasmic reticulum stress; unfolded protein response; obesity;
   adipose tissue dysfunction
ID NUCLEAR FACTOR-Y; UNFOLDED PROTEIN RESPONSE; INDUCED HEPATIC STEATOSIS;
   INSULIN-RESISTANCE; ER STRESS; INFLAMMATORY RESPONSES; ADIPONECTIN
   EXPRESSION; METABOLIC-DISORDERS; KAPPA-B; DIET
AB Adipose tissue dysfunction plays an important role in metabolic diseases associated with chronic inflammation, insulin resistance and lipid ectopic deposition in obese patients. In recent years, it has been found that under the stimulation of adipocyte endoplasmic reticulum stress (ERS), the over-activated ER unfolded protein response (UPR) exacerbates the inflammatory response of adipose tissue by interfering with the normal metabolism of adipose tissue, promotes the secretion of adipokines, and affects the browning and thermogenic pathways of adipose tissue, ultimately leading to the manifestation of metabolic syndrome such as ectopic lipid deposition and disorders of glucolipid metabolism in obese patients. This paper mainly summarizes the relationship between adipocyte ERS and obese adipose tissue dysfunction and provides an overview of the mechanisms by which ERS induces metabolic disorders such as catabolism, thermogenesis and inflammation in obese adipose tissue through the regulation of molecules and pathways such as NF-KB, ADPN, STAMP2, LPIN1, TRIP-Br2, NF-Y and SIRT2 and briefly describes the current mechanisms targeting adipocyte endoplasmic reticulum stress to improve obesity and provide ideas for intervention and treatment of obese adipose tissue dysfunction.
C1 [Xu, Shengjie; Wu, Tao] Shandong Univ Tradit Chinese Med, Clin Coll 1, Jinan 250000, Shandong, Peoples R China.
   [Xi, Jiaqiu] Shandong Univ Tradit Chinese Med, Jinan 250000, Peoples R China.
   [Wang, Zhonglin] Shandong Univ Tradit Chinese Med, Affiliated Hosp, Jinan 250014, Peoples R China.
C3 Shandong University of Traditional Chinese Medicine; Shandong University
   of Traditional Chinese Medicine; Shandong University of Traditional
   Chinese Medicine
RP Wang, ZL (corresponding author), Shandong Univ Tradit Chinese Med, Affiliated Hosp, Jinan 250014, Peoples R China.
EM zydoctor7@126.com
OI Xu, Shengjie/0009-0004-7263-0420
FU Shandong Traditional Chinese Medicine Science and Technology Development
   Project Fund of China [2019-0108]; Qilu Internal Medicine Academic
   School of Blood Turbidity Inheritance Project Fund of China;  [45]
FX The Shandong Traditional Chinese Medicine Science and Technology
   Development Project Fund of China (2019-0108) and Qilu Internal Medicine
   Academic School of Blood Turbidity Inheritance Project Fund of China (Lu
   WeiHan [2021] No. 45) funded this study.
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NR 110
TC 11
Z9 11
U1 4
U2 15
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
EI 1178-7074
J9 INT J GEN MED
JI Int. J. Gen. Med.
PY 2023
VL 16
BP 4405
EP 4418
DI 10.2147/IJGM.S428482
PG 14
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA T8HQ0
UT WOS:001080340200001
PM 37789878
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Wolf, AM
   Asoh, S
   Hiranuma, H
   Ohsawa, I
   Iio, K
   Satou, A
   Ishikura, M
   Ohta, S
AF Wolf, Alexander M.
   Asoh, Sadamitsu
   Hiranuma, Hidenori
   Ohsawa, Ikuroh
   Iio, Kumiko
   Satou, Akira
   Ishikura, Masaharu
   Ohta, Shigeo
TI Astaxanthin protects mitochondrial redox state and functional integrity
   against oxidative stress
SO JOURNAL OF NUTRITIONAL BIOCHEMISTRY
LA English
DT Article
DE Oxidative stress; Mitochondrial membrane potential; Oxygen consumption;
   Redox-sensitive GFP; Astaxanthin; Metabolic syndrome
ID COMPLEX-I ACTIVITY; GLUTATHIONE DEPLETION; INHIBITION; CELLS;
   2',7'-DICHLORODIHYDROFLUORESCEIN; ANTIOXIDANTS; INCREASES; MECHANISM;
   MEMBRANE; PROBE
AB Mitochondria combine the production of energy with an efficient chain of reduction-oxidation (redox) reactions but also with the unavoidable production of reactive oxygen species. Oxidative stress leading to mitochondrial dysfunction is a critical factor in many diseases, such as cancer and neurodegenerative and lifestyle-related diseases. Effective antioxidants thus offer great therapeutic and preventive promise. Investigating the efficacy of antioxidants, we found that a carotenoid, astaxanthin (AX), decreased physiologically occurring oxidative stress and protected cultured cells against strong oxidative stress induced with a respiratory inhibitor. Moreover, AX improved maintenance of a high mitochondrial membrane potential and stimulated respiration. Investigating how AX stimulates and interacts with mitochondria, a redox-sensitive fluorescent protein (roGFP1) was stably expressed in the cytosol and mitochondrial matrix to measure the redox state in the respective compartments. AX at nanomolar concentrations was effective in maintaining mitochondria in a reduced state. Additionally, AX improved the ability of mitochondria to remain in a reduced state under oxidative challenge. Taken together, these results suggest that AX is effective in improving mitochondrial function through retaining mitochondria in the reduced state. (C) 2010 Elsevier Inc. All rights reserved.
C1 [Wolf, Alexander M.; Asoh, Sadamitsu; Hiranuma, Hidenori; Ohsawa, Ikuroh; Ohta, Shigeo] Nippon Med Sch, Inst Dev & Aging Sci, Dept Biochem & Cell Biol, Nakahara Ku, Kanagawa 2118533, Japan.
   [Ohsawa, Ikuroh] Nippon Med Sch, Inst Dev & Aging Sci, Ctr Mol Hydrogen Med, Nakahara Ku, Kanagawa 2118533, Japan.
   [Iio, Kumiko; Satou, Akira; Ishikura, Masaharu] Yamaha Motor Co Ltd, Inst Life Sci, Shizuoka 4370061, Japan.
C3 Nippon Medical School; Nippon Medical School; Yamaha Motor Company
RP Ohta, S (corresponding author), Nippon Med Sch, Inst Dev & Aging Sci, Dept Biochem & Cell Biol, Nakahara Ku, Kanagawa 2118533, Japan.
EM ohta@nms.ac.jp
RI Ohta, Shigeo/HKO-9826-2023
OI Wolf, Alexander/0000-0002-5755-8756; Ohta, Shigeo/0000-0002-2539-470X
FU Japan Society for the Promotion of Science
FX We express our deep gratitude to Prof. Jim Remington and his team for
   kindly providing the roGFP1 containing plasmids. Alexander Wolf was
   supported by a Postdoctoral Fellowship and grant from the Japan Society
   for the Promotion of Science.
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NR 48
TC 144
Z9 155
U1 1
U2 47
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0955-2863
EI 1873-4847
J9 J NUTR BIOCHEM
JI J. Nutr. Biochem.
PD MAY
PY 2010
VL 21
IS 5
BP 381
EP 389
DI 10.1016/j.jnutbio.2009.01.011
PG 9
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA 588FW
UT WOS:000277054500004
PM 19423317
DA 2025-06-11
ER

PT J
AU Sumii, K
   Miyake, H
   Enatsu, N
   Matsushita, K
   Fujisawa, M
AF Sumii, K.
   Miyake, H.
   Enatsu, N.
   Matsushita, K.
   Fujisawa, M.
TI Prospective assessment of health-related quality of life in men with
   late-onset hypogonadism who received testosterone replacement therapy
SO ANDROLOGIA
LA English
DT Article
DE health-related quality of life; late-onset hypogonadism; testosterone
   replacement therapy
ID METABOLIC SYNDROME; OLDER MEN; EXOGENOUS TESTOSTERONE; ERECTILE
   DYSFUNCTION; VISCERAL ADIPOSITY; SEXUAL FUNCTION; FINASTERIDE;
   DEFICIENCY; PARAMETERS; ANDROGENS
AB The objective of this study was to characterise the status of health-related quality of life (HRQOL) in Japanese men with late-onset hypogonadism (LOH) treated with testosterone replacement therapy (TRT). HRQOL in 69 consecutive Japanese men with LOH undergoing TRT for at least 6months was prospectively evaluated before and 6months after the initiation of TRT using the Medical Outcomes Study 8-Item Short-Form Health Survey (SF-8). All eight-scale scores except for bodily pain (BP) in the 69 patients at 6months after the introduction of TRT significantly improved compared with those before TRT; however, all scale scores except for BP in the 69 patients were significantly inferior to those in age-matched Japanese controls irrespective of the timing of SF-8. Multivariate analyses of several parameters revealed that both age and Aging Male Symptom (AMS) score had an independent impact on mental health (MH), despite the lack of an independent association between any score and the remaining factors examined. TRT appeared to significantly improve the status of HRQOL in men with LOH; however, even after the introduction of TRT, HRQOL associated with MH remained significantly impaired in elderly men and/or those with a high AMS score.
C1 [Sumii, K.; Miyake, H.; Enatsu, N.; Matsushita, K.; Fujisawa, M.] Kobe Univ, Fac Med, Grad Sch Med, Div Urol,Dept Surg Related, Kobe, Hyogo 6500017, Japan.
C3 Kobe University
RP Sumii, K (corresponding author), Kobe Univ, Fac Med, Grad Sch Med, Div Urol,Dept Surg Related,Chuo Ku, 7-5-1 Kusunoki Cho, Kobe, Hyogo 6500017, Japan.
EM ksumii@med.kobe-u.ac.jp
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NR 27
TC 3
Z9 3
U1 0
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0303-4569
EI 1439-0272
J9 ANDROLOGIA
JI Andrologia
PD MAR
PY 2016
VL 48
IS 2
BP 198
EP 202
DI 10.1111/and.12433
PG 5
WC Andrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA DD9CW
UT WOS:000370224300010
PM 25988884
OA gold
DA 2025-06-11
ER

PT J
AU Hernández-Ruiz, RG
   Olivares-Ochoa, XC
   Salinas-Varela, Y
   Guajardo-Espinoza, D
   Roldán-Flores, LG
   Rivera-Leon, EA
   López-Quintero, A
AF Hernandez-Ruiz, Rocio Guadalupe
   Olivares-Ochoa, Xochitl Citalli
   Salinas-Varela, Yahatziri
   Guajardo-Espinoza, David
   Roldan-Flores, Luis Gustavo
   Rivera-Leon, Edgar Alfonso
   Lopez-Quintero, Andres
TI Phenolic Compounds and Anthocyanins in Legumes and Their Impact on
   Inflammation, Oxidative Stress, and Metabolism: Comprehensive Review
SO MOLECULES
LA English
DT Review
DE phenolic compounds; anthocyanins; legumes; inflammation; metabolism
ID HIGH-FAT DIET; SOYBEAN SEED COAT; IN-VITRO; ANTIOXIDANT ACTIVITY; RICH
   EXTRACTS; LENTIL; BIOAVAILABILITY; ADULTS; HEALTH; CYANIDIN-3-GLUCOSIDE
AB Inflammation, oxidative stress, and metabolic diseases are intricately linked in a complex, self-reinforcing relationship. Inflammation can induce oxidative stress, while oxidative stress can trigger inflammatory responses, creating a cycle that contributes to the development and progression of metabolic disorders; in addition, these effects can be observed at systemic and local scales. Both processes lead to cellular damage, mitochondrial dysfunction, and insulin resistance, particularly affecting adipose tissue, the liver, muscles, and the gastrointestinal tract. This results in impaired metabolic function and energy production, contributing to conditions such as type 2 diabetes, obesity, and metabolic syndrome. Legumes are a good source of phenolic compounds and anthocyanins that exert an antioxidant effect-they directly neutralize reactive oxygen species and free radicals, reducing oxidative stress. In vivo, in vitro, and clinical trial studies demonstrate that these compounds can modulate key cellular signaling pathways involved in inflammation and metabolism, improving insulin sensitivity and regulating lipid and glucose metabolism. They also exert anti-inflammatory effects by inhibiting proinflammatory enzymes and cytokines. Additionally, anthocyanins and phenolics may positively influence the gut microbiome, indirectly affecting metabolism and inflammation.
C1 [Hernandez-Ruiz, Rocio Guadalupe; Olivares-Ochoa, Xochitl Citalli; Salinas-Varela, Yahatziri; Lopez-Quintero, Andres] Univ Guadalajara UdeG, Ctr Univ Ciencias Salud CUCS, Doctorado Ciencias Nutr Traslac, Guadalajara 44340, Jalisco, Mexico.
   [Guajardo-Espinoza, David; Roldan-Flores, Luis Gustavo] UdeG, Licenciatura Med Cirujano & Partero, CUCS, Guadalajara 44340, Jalisco, Mexico.
   [Rivera-Leon, Edgar Alfonso; Lopez-Quintero, Andres] UdeG, CUCS, Inst Nutrigenet & Nutrigenom Traslac, Guadalajara 44340, Jalisco, Mexico.
   [Rivera-Leon, Edgar Alfonso] UdeG, Ctr Univ Altos CUAltos, Dept Ciencias Salud, Tepatitlan De Morelos 47620, Jalisco, Mexico.
RP López-Quintero, A (corresponding author), Univ Guadalajara UdeG, Ctr Univ Ciencias Salud CUCS, Doctorado Ciencias Nutr Traslac, Guadalajara 44340, Jalisco, Mexico.; López-Quintero, A (corresponding author), UdeG, CUCS, Inst Nutrigenet & Nutrigenom Traslac, Guadalajara 44340, Jalisco, Mexico.
EM rocio.hernandez9558@alumnos.udg.mx; xochitl.olivares2305@alumnos.udg.mx;
   patricia.salinas3709@alumnos.udg.mx; edgar.rleon@academicos.udg.mx;
   andres.lopezq@academicos.udg.mx
OI Olivares-Ochoa, Xochitl Citlalli/0000-0002-4456-4620; RIVERA LEON, EDGAR
   ALFONSO/0000-0002-4980-3053; LOPEZ-QUINTERO, ANDRES/0000-0002-5151-041X;
   Salinas Varela, Yahatziri/0009-0008-9970-1398; Hernandez Ruiz,
   Rocio/0000-0001-7303-1164
FU Universidad de Guadalajara, Centro Universitario de Ciencias de la Salud
FX This research was funded by Universidad de Guadalajara, Centro
   Universitario de Ciencias de la Salud.
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NR 109
TC 1
Z9 1
U1 8
U2 8
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1420-3049
J9 MOLECULES
JI Molecules
PD JAN
PY 2025
VL 30
IS 1
AR 174
DI 10.3390/molecules30010174
PG 41
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA R8D3P
UT WOS:001393682900001
PM 39795230
OA gold
DA 2025-06-11
ER

PT J
AU Yubero-Serrano, EM
   Gonzalez-Guardia, L
   Rangel-Zuñiga, O
   Delgado-Lista, J
   Gutierrez-Mariscal, FM
   Perez-Martinez, P
   Delgado-Casado, N
   Cruz-Teno, C
   Tinahones, FJ
   Villalba, JM
   Perez-Jimenez, F
   Lopez-Miranda, J
AF Yubero-Serrano, Elena M.
   Gonzalez-Guardia, Lorena
   Rangel-Zuniga, Oriol
   Delgado-Lista, Javier
   Gutierrez-Mariscal, Francisco M.
   Perez-Martinez, Pablo
   Delgado-Casado, Nieves
   Cruz-Teno, Cristina
   Tinahones, Francisco J.
   Villalba, Jose M.
   Perez-Jimenez, Francisco
   Lopez-Miranda, Jose
TI Mediterranean Diet Supplemented With Coenzyme Q10 Modifies
   the Expression of Proinflammatory and Endoplasmic Reticulum
   Stress-Related Genes in Elderly Men and Women
SO JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL
   SCIENCES
LA English
DT Article
DE CoQ(10); Mediterranean diet; Chronic inflammation; Endoplasmic reticulum
   stress; Gene expression
ID NF-KAPPA-B; VITAMIN-E; OXIDATIVE STRESS; ENDOTHELIAL FUNCTION;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; MONONUCLEAR-CELLS;
   HEART-DISEASE; OLIVE OIL; ACTIVATION
AB We have investigated whether the quality of dietary fat and supplementation with coenzyme Q(10) (CoQ) modifies expression of genes related with inflammatory response and endoplasmic reticulum stress in elderly persons. Twenty participants received three diets for 4 weeks each: Mediterranean diet + CoQ (Med + CoQ), Mediterranean diet (Med), and saturated fatty acid-rich diet (SFA). After 12-hour fast, volunteers consumed a breakfast with a fat composition similar to that consumed in each of the diets. Med and Med + CoQ diets produced a lower fasting calreticulin, IL-1b, and JNK-1 gene expression; a lower postprandial p65, IKK-b, MMP-9, IL-1b, JNK-1, sXBP-1, and BiP/Grp78 gene expression; and a higher postprandial IkB-a gene expression compared with the SFA diet. Med + CoQ diet produced a lower postprandial decrease p65 and IKK-b gene expression compared with the other diets. Our results support the anti-inflammatory effect of Med diet and that exogenous CoQ supplementation in synergy with a Med diet modulates the inflammatory response and endoplasmic reticulum stress.
C1 [Yubero-Serrano, Elena M.; Gonzalez-Guardia, Lorena; Rangel-Zuniga, Oriol; Delgado-Lista, Javier; Gutierrez-Mariscal, Francisco M.; Perez-Martinez, Pablo; Delgado-Casado, Nieves; Cruz-Teno, Cristina; Perez-Jimenez, Francisco; Lopez-Miranda, Jose] Univ Cordoba, Reina Sofia Univ Hosp, IMIBIC, Lipids & Atherosclerosis Unit, E-14004 Cordoba, Spain.
   [Tinahones, Francisco J.] Hosp Virgen de la Victoria, Malaga, Spain.
   [Villalba, Jose M.] Univ Cordoba, Dept Cell Biol Physiol & Immunol, E-14004 Cordoba, Spain.
C3 Hospital Universitario Reina Sofia - Cordoba; Universidad de Cordoba;
   Hospital Virgen de la Victoria; Universidad de Cordoba
RP Lopez-Miranda, J (corresponding author), Univ Cordoba, Reina Sofia Univ Hosp, IMIBIC, Lipids & Atherosclerosis Unit, Avda Menendez Pidal S-N, E-14004 Cordoba, Spain.
EM jlopezmir@uco.es
RI Yubero-Serrano, Elena/H-4832-2013; Jimenez, Francisco/AAJ-9559-2021;
   Lopez-Miranda, Jose/Y-8306-2019; Delgado-Lista, Javier/KAM-7412-2024;
   Tinahones, Francisco/AAB-2882-2020; Mariscal, Francisco/AAH-3689-2020;
   Gutierrez Mariscal, Francisco Miguel/F-9804-2016; Perez Martinez,
   Pablo/AEL-6176-2022
OI Gutierrez Mariscal, Francisco Miguel/0000-0003-3353-2188; Perez
   Martinez, Pablo/0000-0001-7716-8117; Villalba Montoro, Jose
   Manuel/0000-0001-8554-3802; Perez Jimenez,
   Francisco/0000-0001-9808-1280; Tinahones, Francisco
   J/0000-0001-6871-4403; Perez-Jimenez, Francisco/0000-0001-7499-7681;
   Yubero-Serrano, Elena M/0000-0002-2733-5359; Lopez-Miranda,
   Jose/0000-0002-8844-0718; Delgado Lista, Francisco
   Javier/0000-0002-2982-2716; Rangel-Zuniga, Oriol
   Alberto/0000-0003-3495-5705
FU Ministerio de Ciencia e Innovacion [AGL 2004-07907, AGL2006-01979,
   AGL2009-12270, FIS PI10/01041]; Consejeria de Innovacion, Ciencia y
   Empresa, Junta de Andalucia [P06-CTS-01425, CTS5015]; Consejeria de
   Salud, Junta de Andalucia [06/128, 07/43, PI0193/2009, 06/129,
   PI-0252/09, PI-0058/10]; Kaneka Corporation (Japan)
FX This study was supported in part by research grants from the Ministerio
   de Ciencia e Innovacion (AGL 2004-07907, AGL2006-01979, and
   AGL2009-12270 to J.L-M. and FIS PI10/01041 to P. P-M.), Consejeria de
   Innovacion, Ciencia y Empresa, Junta de Andalucia (P06-CTS-01425 to
   J.L-M. and CTS5015 to F.P-J.), Consejeria de Salud, Junta de Andalucia
   (06/128, 07/43, PI0193/2009 to J.L-M., 06/129 to F.P-J., PI-0252/09 to
   J.D-L., and PI-0058/10 to P.P-M.), and Kaneka Corporation (Japan) by the
   production of CoQ and placebo capsules. The CIBEROBN is an initiative of
   the Instituto de Salud Carlos III, Madrid, Spain.
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NR 52
TC 62
Z9 63
U1 0
U2 10
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1079-5006
J9 J GERONTOL A-BIOL
JI J. Gerontol. Ser. A-Biol. Sci. Med. Sci.
PD JAN
PY 2012
VL 67
IS 1
BP 3
EP +
DI 10.1093/gerona/glr167
PG 8
WC Geriatrics & Gerontology; Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA 885PQ
UT WOS:000299791700001
PM 22016358
DA 2025-06-11
ER

PT J
AU Oh, E
   Song, E
   Shin, J
AF Oh, EunJung
   Song, EunJu
   Shin, JungEun
TI Individual Factors Affecting Self-esteem, and Relationships Among
   Self-esteem, Body Mass Index, and Body Image in Patients With
   Schizophrenia
SO ARCHIVES OF PSYCHIATRIC NURSING
LA English
DT Article
DE Body image; Body mass index; Schizophrenia; Self-esteem
ID QUALITY-OF-LIFE; RELATIONS QUESTIONNAIRE; METABOLIC SYNDROME;
   PHYSICAL-ACTIVITY; BIPOLAR DISORDER; WEIGHT; PEOPLE; ASSOCIATIONS;
   OVERWEIGHT; SYMPTOMS
AB The purposes of this study were to identify correlations between body mass index, body image, and self-esteem in patients with schizophrenia and to analyse the specific factors affecting self-esteem. This study had a descriptive design, utilising a cross-sectional survey. Participants were patients with schizophrenia who were admitted to a mental health facility in South Korea. A total of 180 questionnaires were distributed, and an appropriate total sample size of 167 valid questionnaires was analysed. Self-esteem was significantly correlated with body image, the subscale of appearance orientation, and body areas satisfaction. However, body mass index exhibited no significant correlation with any variable. The variables found to have a significant explanatory power of 21.4% were appearance orientation and body areas satisfaction. The explanatory power of all factors was 33.6%. The self-esteem of patients with schizophrenia was influenced by body mass index and body image. The positive symptoms of schizophrenia can be controlled by medication, whereas negative symptoms can be improved through education and nursing care with medication. Thus, psychiatric nurses should develop education and care programs that contribute to the positive body image and self-esteem of patients with schizophrenia.
C1 [Oh, EunJung] Jeonbuk Sci Coll, Dept Nursing, Jeongeup, South Korea.
   [Song, EunJu] Wonkwang Univ, Dept Nursing, 460 Iksan Daero, Iksan 54338, Jeonbuk, South Korea.
   [Shin, JungEun] Maeumsarang Hosp, Dept Nursing, Jeollabuk Do, South Korea.
C3 Wonkwang University
RP Song, E (corresponding author), Wonkwang Univ, Dept Nursing, 460 Iksan Daero, Iksan 54338, Jeonbuk, South Korea.
EM chanjun@wku.ac.kr
FU Wonkwang University
FX This paper was supported by Wonkwang University in 2017.
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NR 55
TC 14
Z9 14
U1 0
U2 20
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0883-9417
EI 1532-8228
J9 ARCH PSYCHIAT NURS
JI Arch. Psychiatr. Nurs.
PD DEC
PY 2017
VL 31
IS 6
BP 588
EP 595
DI 10.1016/j.apnu.2017.08.007
PG 8
WC Nursing; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Psychiatry
GA FP3XJ
UT WOS:000417551000011
PM 29179826
DA 2025-06-11
ER

PT J
AU Långstedt, C
   Bressington, D
   Välimäki, M
AF Langstedt, Camilla
   Bressington, Daniel
   Valimaki, Maritta
TI Understanding Implementation Fidelity of Physical Health Screening in
   Mental Health Nursing: A Mixed Methods Study
SO ISSUES IN MENTAL HEALTH NURSING
LA English
DT Article
ID QUALITATIVE CONTENT-ANALYSIS; METABOLIC SYNDROME; NURSES VIEWS; ILLNESS;
   PEOPLE; CARE; LEADERSHIP; ADHERENCE; STAFF; SCHIZOPHRENIA
AB Physical health screening for patients with schizophrenia spectrum disorders is suboptimal despite patients' poor physical health and nurses' willingness to conduct assessments. However, this inadequate service provision is poorly understood. The purpose of this study was to describe nurses' adherence to conducting screening with the Finnish Health Improvement Profile and related factors. An explanatory, sequential two-phase mixed-methods design was used. A quantitative method was used to describe nurses' adherence and a qualitative approach to describe moderating factors. The data were collected and analyzed separately and later integrated into one dataset. Generally, screening was implemented as intended regarding content adherence despite very few nurses conducting the screening. Analysis identified four main themes related to adherence. Comprehensiveness of policy description included complexity and duration; strategies to facilitate implementation included fragmented information, instructions, nurses' fragmented work tasks, management and equipment; quality of delivery included preparedness and nurses' confidence and skills; and participant responsiveness included nurses' enthusiasm in screening, nurses' engagement in screening, patient willingness to participate, patient's refusal to participate, patient's cognitive capacity and collaborative screening. For successful screening, the utility and feasibility of the screening tool would need to be reevaluated after addressing some of the barriers identified as moderating factors.
C1 [Langstedt, Camilla; Valimaki, Maritta] Univ Turku, Fac Med, Dept Nursing Sci, Kiinamyllynkatu 10,Med B, Turku 20520, Finland.
   [Bressington, Daniel] Chiang Mai Univ, Fac Nursing, Chiang Mai, Thailand.
   [Valimaki, Maritta] Univ Helsinki, Sch Publ Hlth, Helsinki, Finland.
   [Valimaki, Maritta] Univ Helsinki, Helsinki, Finland.
   [Valimaki, Maritta] Helsinki Univ Hosp, Helsinki, Finland.
C3 University of Turku; Chiang Mai University; University of Helsinki;
   University of Helsinki; University of Helsinki; Helsinki University
   Central Hospital
RP Långstedt, C (corresponding author), Univ Turku, Fac Med, Dept Nursing Sci, Kiinamyllynkatu 10,Med B, Turku 20520, Finland.
EM camaka@utu.fi
RI Bressington, Daniel/G-2789-2017; Valimaki, Maritta/E-7092-2017
OI Bressington, Daniel/0000-0003-0951-2208; Valimaki,
   Maritta/0000-0001-7234-2454
FU Helsinki University Hospitals (HUH) Nursing Research Center (NRC); HUH
   Funding
FX Helsinki University Hospitals (HUH) Nursing Research Center (NRC) and
   HUH Funding, Psychiatry supported this study by granting a paid research
   period for the first author (CL).
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NR 99
TC 0
Z9 0
U1 0
U2 0
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 0161-2840
EI 1096-4673
J9 ISSUES MENT HEALTH N
JI Issues Ment. Health Nurs.
PD MAR 4
PY 2025
VL 46
IS 3
BP 267
EP 279
DI 10.1080/01612840.2025.2464692
EA FEB 2025
PG 13
WC Nursing; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Psychiatry
GA Z5R3U
UT WOS:001433525500001
PM 40014812
DA 2025-06-11
ER

PT J
AU Titmuss, A
   Korula, S
   Wicklow, B
   Nadeau, KJ
AF Titmuss, Angela
   Korula, Sophy
   Wicklow, Brandy
   Nadeau, Kristen J.
TI Youth-onset Type 2 Diabetes: An Overview of Pathophysiology, Prognosis,
   Prevention and Management
SO CURRENT DIABETES REPORTS
LA English
DT Review
DE Type 2 diabetes; Child; Youth; Insulin; Intergenerational; Hyperglycemia
ID BETA-CELL FUNCTION; IMPAIRED GLUCOSE-TOLERANCE; PHYSICAL-ACTIVITY;
   YOUNG-ADULTS; CARDIOVASCULAR-DISEASE; INTRAUTERINE EXPOSURE; INSULIN
   SENSITIVITY; METABOLIC SYNDROME; DISPOSITION INDEX; HIGH PREVALENCE
AB Purpose of review:This review explores the emerging evidence regarding pathogenesis, future trajectories, treatment options, and phenotypes of youth-onset type 2 diabetes (T2D).Recent findings:Youth-onset T2D is increasing in incidence and prevalence worldwide, disproportionately affecting First Nations communities, socioeconomically disadvantaged youth, and people of colour. Youth-onset T2D differs in pathogenesis to later-onset T2D and progresses more rapidly. It is associated with more complications, and these occur earlier. While there are limited licensed treatment options available, the available medications also appear to have a poorer response in youth with T2D. Multiple interacting factors likely contribute to this rising prevalence, as well as the increased severity of the condition, including structural inequities, increasing obesity and sedentary lifestyles, and intergenerational transmission from in-utero exposure to maternal hyperglycemia and obesity. Youth-onset T2D is also associated with stigma and poorer mental health, and these impact clinical management.Summary:There is an urgent need to develop effective interventions to prevent youth-onset T2D and enhance engagement of affected youth. It is also critical to better understand the differing phenotypes of youth-onset T2D, to effectively target treatments, and to address intergenerational transmission in high-risk populations.
C1 [Titmuss, Angela] Charles Darwin Univ, Menzies Sch Hlth Res, Wellbeing & Preventable Chron Dis Div, POB 41096,Casuarina, Darwin, NT, Australia.
   [Titmuss, Angela] Royal Darwin Hosp, Dept Paediat, Div Women Children & Youth, Darwin, NT, Australia.
   [Korula, Sophy] Christian Med Coll & Hosp, Paediat Endocrinol & Metab Div, Paediat Unit 1, Vellore, Tamil Nadu, India.
   [Korula, Sophy] Latrobe Reg Hosp, Dept Paediat, Traralgon, Vic, Australia.
   [Wicklow, Brandy] Univ Manitoba, Dept Paediat & Child Hlth, Winnipeg, MB, Canada.
   [Wicklow, Brandy] Childrens Hosp, Res Inst Manitoba, Winnipeg, MB, Canada.
   [Nadeau, Kristen J.] Childrens Hosp Colorado, Aurora, CO USA.
   [Nadeau, Kristen J.] Univ Colorado, Sch Med, Anschutz Med Campus, Aurora, CO USA.
C3 Charles Darwin University; Menzies School of Health Research; Royal
   Darwin Hospital; Christian Medical College & Hospital (CMCH) Vellore;
   Latrobe Regional Health; University of Manitoba; University of Manitoba;
   Children's Hospital Research Institute of Manitoba; Children's Hospital
   Colorado; University of Colorado System; University of Colorado Anschutz
   Medical Campus
RP Titmuss, A (corresponding author), Charles Darwin Univ, Menzies Sch Hlth Res, Wellbeing & Preventable Chron Dis Div, POB 41096,Casuarina, Darwin, NT, Australia.; Titmuss, A (corresponding author), Royal Darwin Hosp, Dept Paediat, Div Women Children & Youth, Darwin, NT, Australia.
EM Angela.titmuss@menzies.edu.au
OI Titmuss, Angela/0000-0002-9865-1252
FU Commonwealth Government of Australia MTP Connect Targeted Translation
   Research Accelarator; Commonwealth Government of Australia; Commonwealth
   Government (Co-design of youth-friendly, culturally appropriate models
   of care with Aboriginal and Torres Strait Islander Children and Youth);
   Medical Research Council of Australia
FX The authors' work was supported in part by the Commonwealth Government
   of Australia. AT receives salary and research support from the
   Commonwealth Government (Co-design of youth-friendly, culturally
   appropriate models of care with Aboriginal and Torres Strait Islander
   Children and Youth with type 2 diabetes). The views expressed in this
   publication are those of the authors and do not reflect the views of the
   Commonwealth Government or the National Health and Medical Research
   Council of Australia.
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NR 147
TC 7
Z9 8
U1 2
U2 5
PU CURRENT MEDICINE GROUP
PI PHILADELPHIA
PA 400 MARKET STREET, STE 700, PHILADELPHIA, PA 19106 USA
SN 1534-4827
EI 1539-0829
J9 CURR DIABETES REP
JI Curr. Diabetes Rep.
PD AUG
PY 2024
VL 24
IS 8
BP 183
EP 195
DI 10.1007/s11892-024-01546-2
EA JUL 2024
PG 13
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA ZO5Z3
UT WOS:001261445700001
PM 38958831
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Henderson, DC
AF Henderson, DC
TI Schizophrenia and comorbid metabolic disorders
SO JOURNAL OF CLINICAL PSYCHIATRY
LA English
DT Article
ID INDUCED WEIGHT-GAIN; TYPE-2 DIABETES-MELLITUS; D-2 RECEPTOR OCCUPANCY;
   ATYPICAL ANTIPSYCHOTICS; TRIGLYCERIDE LEVELS; OLANZAPINE; CLOZAPINE;
   RISPERIDONE; QUETIAPINE; LEPTIN
AB Comorbid metabolic disorders in patients with schizophrenia are underrecognized by many health care professionals and patients. That lack of awareness can contribute to serious morbidity and mortality in patients with schizophrenia. Patients with schizophrenia may be at greater risk for metabolic disorders such as insulin resistance, lipid abnormalities, and weight gain. In addition, although the use of atypical antipsychotics in the treatment of schizophrenia offers many positive benefits and may reduce some of the factors related to the morbidity and mortality of the disorder, these drugs appear to be associated with varying degrees of comorbid metabolic disorders, such as metabolic syndrome, and more serious consequences, such as cardiovascular disease. Recent consensus guidelines recommend that metabolic risks be considered when initiating therapy with atypical antipsychotics. Thus, baseline screening and routine monitoring of patient weight, fasting lipid profile, and fasting plasma glucose are essential. In addition, optimal treatment for patients with schizophrenia and comorbid metabolic disorders is best achieved when all parties involved with patient care (mental health and medical community, caregiver/family, and patient) communicate and work together. With proper awareness and cooperation on the part of the medical community, caregivers, and patients, the detrimental consequences that may result from the metabolic disorders addressed in this article can be at least partially offset.
C1 Harvard Univ, Sch Med, Massachusetts Gen Hosp, Schizophrenia Program,Freedom Trail Clin, Boston, MA 02114 USA.
C3 Harvard University; Harvard Medical School; Harvard University Medical
   Affiliates; Massachusetts General Hospital
RP Harvard Univ, Sch Med, Massachusetts Gen Hosp, Schizophrenia Program,Freedom Trail Clin, 25 Staniford St, Boston, MA 02114 USA.
EM dchenderson@partners.org
OI Henderson, David/0000-0001-8755-4505
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NR 84
TC 82
Z9 88
U1 0
U2 6
PU PHYSICIANS POSTGRADUATE PRESS
PI MEMPHIS
PA P O BOX 752870, MEMPHIS, TN 38175-2870 USA
SN 0160-6689
EI 1555-2101
J9 J CLIN PSYCHIAT
JI J. Clin. Psychiatry
PY 2005
VL 66
SU 6
BP 11
EP 20
PG 10
WC Psychology, Clinical; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA 961ON
UT WOS:000231671800003
PM 16107179
DA 2025-06-11
ER

PT J
AU Kelly, AS
   Steinberger, J
   Olson, TP
   Dengel, DR
AF Kelly, Aaron S.
   Steinberger, Julia
   Olson, Thomas P.
   Dengel, Donald R.
TI In the absence of weight loss, exercise training does not improve
   adipokines or oxidative stress in overweight children
SO METABOLISM-CLINICAL AND EXPERIMENTAL
LA English
DT Article
ID C-REACTIVE PROTEIN; TIME PHYSICAL-ACTIVITY; CORONARY-HEART-DISEASE;
   INFLAMMATORY MARKERS; CARDIORESPIRATORY FITNESS; VASCULAR DYSFUNCTION;
   ENDOTHELIAL FUNCTION; COAGULATION MARKERS; METABOLIC SYNDROME; US ADULTS
AB The aim of the present study was to examine the effect of exercise training on adipokines, inflammatory markers, and oxidative stress in overweight children. Nineteen overweight children were randomly assigned to an aerobic exercise training or sedentary control group for 8 weeks. Measurements included peak oxygen uptake (Vo(2)max), body weight and composition, adipokines (C-reactive protein, interleukin 6, tumor necrosis factor g., adiponectin, leptin, and resistin), and oxidative stress (8-isoprostane). There were no differences between groups for change in body weight or composition over the 8 weeks. Exercise training improved Vo(2)max (exercise group, 1.64 +/- 0.13 to 1.85 +/- 0.17 L/min vs control group, 1.83 +/- 0.12 to 1.60 +/- 0.13 L/min, P < .05) but did not change any of the measured adipokines or the marker of systemic oxidative stress.. 8-isoprostane. These data suggest that in the absence of weight loss, exercise training alone does not improve the adipokine profile or levels of oxidative stress in overweight children. (c) 2007 Elsevier Inc. All rights reserved.
C1 Univ Minnesota, Dept Pediat, Minneapolis, MN 55455 USA.
   Univ Minnesota, Sch Kinesiol, Minneapolis, MN 55455 USA.
   St Paul Heart Clin, Dept Res, St Paul, MN 55102 USA.
C3 University of Minnesota System; University of Minnesota Twin Cities;
   University of Minnesota System; University of Minnesota Twin Cities
RP Kelly, AS (corresponding author), Univ Minnesota, Dept Pediat, Minneapolis, MN 55455 USA.
EM kelly105@umn.edu
OI Steinberger, Julia/0000-0002-2892-8594
FU NCRR NIH HHS [M01-RR00400] Funding Source: Medline; NIDDK NIH HHS [1 P30
   DK 50456-08] Funding Source: Medline
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NR 35
TC 114
Z9 125
U1 0
U2 8
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0026-0495
J9 METABOLISM
JI Metab.-Clin. Exp.
PD JUL
PY 2007
VL 56
IS 7
BP 1005
EP 1009
DI 10.1016/j.metabol.2007.03.009
PG 5
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 182ZK
UT WOS:000247542300023
PM 17570265
DA 2025-06-11
ER

PT J
AU Katz, P
   Andonian, BJ
   Huffman, KM
AF Katz, Patricia
   Andonian, Brian J.
   Huffman, Kim M.
TI Benefits and promotion of physical activity in rheumatoid arthritis
SO CURRENT OPINION IN RHEUMATOLOGY
LA English
DT Review
DE exercise; physical activity; rheumatoid arthritis; sedentary
ID INCIDENT COGNITIVE IMPAIRMENT; DEPRESSIVE SYMPTOMS; RESISTANCE EXERCISE;
   INTENSITY EXERCISE; ENERGY-EXPENDITURE; AEROBIC EXERCISE; JOINT HEALTH;
   RISK-FACTORS; FATIGUE; ADULTS
AB Purpose of review The aim of this article is to describe the benefits of physical activity and exercise on rheumatoid arthritis disease activity, functioning, and symptoms; and offer recommendations for promotion of physical activity and exercise among people with rheumatoid arthritis. Recent findings In addition to well-known benefits of exercise such as improving cardiovascular health and metabolic syndrome and reducing obesity, exercise has consistently shown rheumatoid arthritis-specific benefits. Exercise and increases in physical activity improve clinically measured disease activity, reduce symptoms such as fatigue and pain, and improve function and mental health. In spite of these benefits, most people with rheumatoid arthritis are inactive. Patient barriers to engaging in physical activity may include fears of joint damage, rheumatoid arthritis symptoms, and lack of understanding that physical activity improves the symptoms that may be barriers. However, the greatest barrier to healthy levels of physical activity among individuals with rheumatoid arthritis appears to be the lack of direction from healthcare providers. Exercise is safe and highly beneficial for people with rheumatoid arthritis. Because receiving recommendations from healthcare providers may be the factor most strongly associated with engaging in physical activity or exercise, providers are encouraged to give patients positive messages about the benefits of physical activity and the extremely low risks of harm.
C1 [Katz, Patricia] Univ Calif San Francisco, Dept Med, 3333 Calif St, San Francisco, CA 94143 USA.
   [Andonian, Brian J.; Huffman, Kim M.] Duke Univ, Dept Med, Durham, NC USA.
C3 University of California System; University of California San Francisco;
   Duke University
RP Katz, P (corresponding author), Univ Calif San Francisco, Dept Med, 3333 Calif St, San Francisco, CA 94143 USA.
EM Patti.Katz@ucsf.edu
OI Andonian, Brian/0000-0003-1847-0660
FU Rauch Family Rheumatology Research Scholarship
FX B.J.A. was supported by the Rauch Family Rheumatology Research
   Scholarship.
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NR 93
TC 47
Z9 49
U1 3
U2 60
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1040-8711
EI 1531-6963
J9 CURR OPIN RHEUMATOL
JI Curr. Opin. Rheumatol.
PD MAY
PY 2020
VL 32
IS 3
BP 307
EP 314
DI 10.1097/BOR.0000000000000696
PG 8
WC Rheumatology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Rheumatology
GA LB3EE
UT WOS:000524519900013
PM 32141951
DA 2025-06-11
ER

PT J
AU Bolino, MC
   Kelemen, TK
   Matthews, SH
AF Bolino, Mark C.
   Kelemen, Thomas K.
   Matthews, Samuel H.
TI Working 9-to-5? A review of research on nonstandard work schedules
SO JOURNAL OF ORGANIZATIONAL BEHAVIOR
LA English
DT Review
DE compressed schedule; flextime; night shift; nonstandard; shiftwork; work
   schedule
ID NIGHT-SHIFT WORK; FAMILY CONFLICT; METABOLIC SYNDROME; ORGANIZATIONAL
   ATTACHMENT; MORNINGNESS-EVENINGNESS; OCCUPATIONAL INJURIES;
   RETROSPECTIVE COHORT; EMPLOYED PARENTS; MEDIATING ROLE; MENTAL-HEALTH
AB Increasingly, organizations around the world need employees to work weekends and during hours that fall outside of a traditional 9-to-5, Monday through Friday, schedule. At the same time, in recent years, employees have sought more flexible working arrangements that result in longer work shifts that occur on fewer days each week. Although nonstandard work schedules have important organizational implications, much of this research has occurred outside of the management literature. Further, within the management literature, there has been little attempt to review and integrate the findings of prior studies of nonstandard work schedules. In this paper, we review research that has investigated nonstandard work shifts and how they affect work-related outcomes (e.g., job behavior and job attitudes), health-related outcomes (e.g., physiological, behavioral, and psychological consequences), and personal/family-related outcomes (e.g., work-family conflict, divorce, and parent-child relations). Following our review, we identify avenues for future investigations, with a particular emphasis on methodological improvements and research that would facilitate the development of integrated conceptual models that more fully consider the implications of work schedules in the context of other important areas of organizational scholarship.
C1 [Bolino, Mark C.; Kelemen, Thomas K.] Univ Oklahoma, Price Coll Business, Div Management & Int Business, Norman, OK 73019 USA.
   [Matthews, Samuel H.] Univ Northern Iowa, Coll Business Adm, Cedar Falls, IA USA.
C3 University of Oklahoma System; University of Oklahoma - Norman;
   University of Northern Iowa
RP Bolino, MC (corresponding author), Univ Oklahoma, Price Coll Business, Div Management & Int Business, Norman, OK 73019 USA.
EM mbolino@ou.edu
RI Bolino, Mark/HOA-8329-2023
OI Kelemen, Thomas/0000-0002-3637-2258; Bolino, Mark/0000-0003-0736-140X
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NR 208
TC 50
Z9 57
U1 11
U2 152
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0894-3796
EI 1099-1379
J9 J ORGAN BEHAV
JI J. Organ. Behav.
PD FEB
PY 2021
VL 42
IS 2
SI SI
BP 188
EP 211
DI 10.1002/job.2440
EA APR 2020
PG 24
WC Business; Psychology, Applied; Management
WE Social Science Citation Index (SSCI)
SC Business & Economics; Psychology
GA QF2SN
UT WOS:000558364600001
DA 2025-06-11
ER

PT J
AU Castañeda, TR
   Nogueiras, R
   Müller, TD
   Krishna, R
   Grant, E
   Jones, A
   Ottaway, N
   Ananthakrishnan, G
   Pfluger, PT
   Chaudhary, N
   Solomon, MB
   Woods, SC
   Herman, JP
   Tschöp, M
AF Castaneda, T. R.
   Nogueiras, R.
   Mueller, T. D.
   Krishna, R.
   Grant, E.
   Jones, A.
   Ottaway, N.
   Ananthakrishnan, G.
   Pfluger, P. T.
   Chaudhary, N.
   Solomon, M. B.
   Woods, S. C.
   Herman, J. P.
   Tschoep, M. H.
TI Decreased glucose tolerance and plasma adiponectin: resistin ratio in a
   mouse model of post-traumatic stress disorder
SO DIABETOLOGIA
LA English
DT Article
DE Adiponectin; Glucose tolerance; High-fat diet; Mouse; Post-traumatic
   stress disorder; Resistin
ID PITUITARY-ADRENAL-AXIS; INDUCED INSULIN-RESISTANCE; CHRONIC VARIABLE
   STRESS; VIETNAM VETERANS; HEALTH-STATUS; ADRENOCORTICAL AXIS; METABOLIC
   SYNDROME; CUSHINGS-SYNDROME; LIPID-METABOLISM; BODY-FAT
AB Obesity and type 2 diabetes are among the most serious health pathologies worldwide. Stress has been proposed as a factor contributing to the development of these health risk factors; however, the underlying mechanisms that link stress to obesity and diabetes need to be further clarified. Here, we study in mice how chronic stress affects dietary consumption and how that relationship contributes to obesity and diabetes.
   C57BL/6J mice were subjected to chronic variable stress (CVS) for 15 days and subsequently fed with a standard chow or high-fat diet. Food intake, body weight, respiratory quotient, energy expenditure and spontaneous physical activity were measured with a customised calorimetric system and body composition was measured with nuclear magnetic resonance. A glucose tolerance test was also applied and blood glucose levels were measured with a glucometer. Plasma levels of adiponectin and resistin were measured using Lincoplex kits.
   Mice under CVS and fed with a high-fat diet showed impaired glucose tolerance associated with low plasma adiponectin:resistin ratios.
   This study demonstrates, in a novel mouse model, how post-traumatic stress disorder enhances vulnerability for impaired glucose metabolism in an energy-rich environment and proposes a potential adipokine-based mechanism.
C1 [Ananthakrishnan, G.; Pfluger, P. T.; Chaudhary, N.; Tschoep, M. H.] Univ Cincinnati, Dept Med, Div Endocrinol, Metab Dis Inst, Cincinnati, OH 45237 USA.
   [Castaneda, T. R.] Univ Toledo, Coll Pharm, Dept Med & Biol Chem, Toledo, OH 43606 USA.
   [Castaneda, T. R.] Univ Toledo, Ctr Diabet & Endocrine Res, Coll Med, Toledo, OH 43606 USA.
   [Nogueiras, R.] Univ Santiago de Compostela, Dept Physiol, Inst Invest Sanitaria, CIBER Fisiopatol Obesidad & Nutr CIBERobn,Sch Med, Santiago De Compostela, A Coruna, Spain.
   [Jones, A.; Solomon, M. B.; Woods, S. C.; Herman, J. P.] Univ Cincinnati, Dept Psychiat, Metab Dis Inst, Cincinnati, OH 45237 USA.
C3 University System of Ohio; University of Cincinnati; University System
   of Ohio; University of Toledo; University System of Ohio; University of
   Toledo; CIBER - Centro de Investigacion Biomedica en Red; CIBEROBN;
   Universidade de Santiago de Compostela; University System of Ohio;
   University of Cincinnati
RP Tschöp, M (corresponding author), Univ Cincinnati, Dept Med, Div Endocrinol, Metab Dis Inst, 2170 E Galbraith Rd, Cincinnati, OH 45237 USA.
EM tschoemh@ucmail.uc.edu
RI Solomon, Matia/KQV-0178-2024; Tschoep, Matthias/I-5443-2014; Müller,
   Timo/AAZ-4445-2020; Nogueiras, Ruben/AAS-9427-2021; Pfluger,
   Paul/A-3770-2019; Herman, James/D-4960-2015
OI Tschoep, Matthias/0000-0002-4744-371X; Pfluger,
   Paul/0000-0002-8118-7588; Nogueiras, Ruben/0000-0002-9976-9930; Herman,
   James/0000-0003-3571-2406; Muller, Timo/0000-0002-0624-9339
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NR 50
TC 19
Z9 23
U1 1
U2 13
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0012-186X
EI 1432-0428
J9 DIABETOLOGIA
JI Diabetologia
PD APR
PY 2011
VL 54
IS 4
BP 900
EP 909
DI 10.1007/s00125-010-2019-y
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 732VG
UT WOS:000288217200024
PM 21181395
OA Bronze
DA 2025-06-11
ER

PT J
AU Morley-Fletcher, S
   Gaetano, A
   Gao, V
   Gatta, E
   Van Camp, G
   Bouwalerh, H
   Thomas, P
   Nicoletti, F
   Maccari, S
AF Morley-Fletcher, Sara
   Gaetano, Alessandra
   Gao, Vance
   Gatta, Eleonora
   Van Camp, Gilles
   Bouwalerh, Hammou
   Thomas, Pierre
   Nicoletti, Ferdinando
   Maccari, Stefania
TI Postpartum Oxytocin Treatment via the Mother Reprograms Long-Term
   Behavioral Disorders Induced by Early Life Stress on the Plasma and
   Brain Metabolome in the Rat
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE early life stress; plasma; prefrontal cortex; oxytocin; secondary bile
   acid; glutathione; behavior; corticosterone; glucose
ID CSF HISTAMINE; CONSEQUENCES; NARCOLEPSY; MECHANISMS
AB The rat model of perinatal stress (PRS), in which exposure of pregnant dams to restraint stress reduces maternal behavior, is characterized by a metabolic profile that is reminiscent of the "metabolic syndrome". We aimed to identify plasma metabolomic signatures linked to long-term programming induced by PRS in aged male rats. This study was conducted in the plasma and frontal cortex. We also investigated the reversal effect of postpartum carbetocin (Cbt) on these signatures, along with its impact on deficits in cognitive, social, and exploratory behavior. We found that PRS induced long-lasting changes in biomarkers of secondary bile acid metabolism in the plasma and glutathione metabolism in the frontal cortex. Cbt treatment demonstrated disease-dependent effects by reversing the metabolite alterations. The metabolomic signatures of PRS were associated with long-term cognitive and emotional alterations alongside endocrinological disturbances. Our findings represent the first evidence of how early life stress may alter the metabolomic profile in aged individuals, thereby increasing vulnerability to CNS disorders. This raises the intriguing prospect that the pharmacological activation of oxytocin receptors soon after delivery through the mother may rectify these alterations.
C1 [Morley-Fletcher, Sara; Gaetano, Alessandra; Gao, Vance; Gatta, Eleonora; Van Camp, Gilles; Bouwalerh, Hammou; Maccari, Stefania] Univ Lille, UGSF, CNRS, GlycoStress Team,Unite Glycobiol Structurale & Fon, F-59000 Lille, France.
   [Thomas, Pierre] Univ Lille, CHU Lille, Hop Fontan, INSERM,U1172 ,Lab Lille Neurosci & Cognit,Equipe P, F-59000 Lille, France.
   [Nicoletti, Ferdinando] Univ Sapienza Rome, Dept Physiol & Pharmacol V Erspamer, I-00185 Rome, Italy.
   [Nicoletti, Ferdinando] IRCCS Neuromed, I-86077 Pozzilli, Italy.
   [Maccari, Stefania] Univ Sapienza Rome, Dept Sci & Med Surg Biotechnol, I-00185 Rome, Italy.
   [Gao, Vance] Univ Lille, Inst Pasteur Lille, CHU Lille, U1011 EGID, F-59000 Lille, France.
   [Gatta, Eleonora] Chicago Biomed Consortium, Evanston, IL 60208 USA.
   [Nicoletti, Ferdinando; Maccari, Stefania] ULille, CNRS, Int Associated Lab LIA,Lab Int Associated LIA CNRS, France Italy Perinatal Stress & Neurodegenerat Dis, Lille, France.
   [Nicoletti, Ferdinando; Maccari, Stefania] ULille, IRCCS Neuromed, CNRS, Sapienza UniRome 1, Lille, France.
C3 Universite de Lille; Centre National de la Recherche Scientifique
   (CNRS); Universite de Lille; CHU Lille; Institut National de la Sante et
   de la Recherche Medicale (Inserm); Sapienza University Rome; IRCCS
   Neuromed; Sapienza University Rome; Universite de Lille; CHU Lille;
   Pasteur Network; Institut Pasteur Lille; Institut National de la Sante
   et de la Recherche Medicale (Inserm); Universite de Lille; Centre
   National de la Recherche Scientifique (CNRS); Universite de Lille;
   Centre National de la Recherche Scientifique (CNRS)
RP Maccari, S (corresponding author), Univ Lille, UGSF, CNRS, GlycoStress Team,Unite Glycobiol Structurale & Fon, F-59000 Lille, France.; Maccari, S (corresponding author), Univ Sapienza Rome, Dept Sci & Med Surg Biotechnol, I-00185 Rome, Italy.; Maccari, S (corresponding author), ULille, CNRS, Int Associated Lab LIA,Lab Int Associated LIA CNRS, France Italy Perinatal Stress & Neurodegenerat Dis, Lille, France.; Maccari, S (corresponding author), ULille, IRCCS Neuromed, CNRS, Sapienza UniRome 1, Lille, France.
EM sara.morley-fletcher@univ-lille.fr; alessandra.gaetano@univ-lille.fr;
   vance.gao@univ-lille.fr; eleonora.gatta@northwestern.edu;
   gilles.van-camp@univ-lille.fr; hammou.bouwalerh@univ-lille.fr;
   pierre.thomas@univ-lille.fr; ferdinandonicoletti@hotmail.com;
   stefania.maccari@univ-lille.fr
RI BOUWALERH, Hammou/P-1608-2019
OI Gao, Vance/0000-0003-4492-1154; Morley-Fletcher,
   Sara/0000-0003-0423-5563
FU Agence Nationale de la Recherche (ANR PERISTRESS)
FX This research was funded by Agence Nationale de la Recherche (ANR
   PERISTRESS (PIS. Maccari).
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NR 51
TC 0
Z9 0
U1 3
U2 3
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD MAR
PY 2024
VL 25
IS 5
AR 3014
DI 10.3390/ijms25053014
PG 23
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA KV7V7
UT WOS:001182812600001
PM 38474260
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Rentería, I
   Berumen, EA
   García, MEA
   Carrasco-Legleu, CE
   De León-Fierro, LG
   Arenas-Berumen, EA
AF Renteria, Ivan
   Arenas Berumen, Ever
   Arellano Garcia, Maria Evarista
   Esther Carrasco-Legleu, Claudia
   Guillermina De Leon-Fierro, Lidia
   Alejandro Arenas-Berumen, Enrique
TI FACTORS AFFECTING OXIDATIVE DAMAGE IN OBESE CHILDREN: AN EXPLORATORY
   STUDY
SO NUTRICION HOSPITALARIA
LA English
DT Article
DE Oxidative stress; Childhood obesity; Damage to DNA; Total antioxidant
   capacity
ID LIPID-PEROXIDATION; DNA-ADDUCTS; STRESS; ADOLESCENTS; HUMANS; CANCER;
   REPAIR; SITES
AB Introduction: Obesity is a metabolic disorder that creates oxidizing conditions, which can generate high levels of physiological stress as well as a disturbance in the state of redox cell known as Oxidative Stress.
   Objective: To examine the association between the damage on chromosomal DNA and the total antioxidant capacity (TAC) in obese children with severe obesity.
   Methods: Participants were 11 children with a mean age and body mass index of 9.5 +/- 1.2 years and 27.7 +/- 3.3 kg/m(2), respectively, from which venous blood samples were obtained to determine distinctive risk factors of metabolic syndrome, the number of DNA abasic sites (AS) and TAC levels. Biomarkers were quantified from spectrophotometric techniques and ELISA assays.
   Results: Were identified 4.1 +/- 4.0x105 AS and TAC of 0.218 +/- 0.03 mmoUL, and an inverse correlation between AS and TAC (r = -0.63, p=0.038). These results suggest an imbalance in reduction-oxidation status (REDOX) within the cell.
   Conclusion: Increased AS and decreased TAC concentrations in the presence of severe obesity suggest that oxidative stress could be considered as an important risk factor closely linked to the early development of comorbidities associated to obesity.
C1 [Renteria, Ivan; Arenas Berumen, Ever] Univ Autonoma Baja California, Fac Deportes, Ensenada, Baja California, Mexico.
   [Arenas Berumen, Ever] Univ Autonoma Baja California, Escuela Ciencias Salud, Ensenada, Baja California, Mexico.
   [Arellano Garcia, Maria Evarista] Univ Autonoma Baja California, Fac Ciencias, Ensenada, Baja California, Mexico.
   [Esther Carrasco-Legleu, Claudia; Guillermina De Leon-Fierro, Lidia] Univ Autonoma Chihuahua, Fac Ciencias Cultura Fis, Chihuahua 31124, Mexico.
C3 Universidad Autonoma de Baja California; Universidad Autonoma de Baja
   California; Universidad Autonoma de Chihuahua
RP Carrasco-Legleu, CE (corresponding author), Univ Autonoma Chihuahua, Circuito Univ S-N Fracc,Apartado Postal 21585, Chihuahua 31124, Mexico.
EM ccarrasco@uach.mx
RI De León, Lidia/IZE-2174-2023; RENTERIA, IVAN/N-9343-2019; Arellano
   Garcia, Maria Evarista/B-8084-2014; De Leon, Lidia G./R-3580-2016
OI Arellano Garcia, Maria Evarista/0000-0002-0997-6902; Carrasco-Legleu,
   Claudia E./0000-0003-0899-3484; De Leon, Lidia G./0000-0002-7778-1314;
   Renteria, Ivan/0000-0001-5179-1699
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NR 26
TC 2
Z9 2
U1 0
U2 6
PU ARAN EDICIONES, S L
PI MADRID
PA CASTELLO, 128, 1O, MADRID, 28006, SPAIN
SN 0212-1611
EI 1699-5198
J9 NUTR HOSP
JI Nutr. Hosp.
PD APR
PY 2015
VL 31
IS 4
BP 1499
EP 1503
DI 10.3305/nh.2015.31.4.8508
PG 5
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA CG0AE
UT WOS:000352928200006
PM 25795933
DA 2025-06-11
ER

PT J
AU Park, DY
   Kim, HJ
   Kim, CH
   Lee, JY
   Han, K
   Choi, JH
AF Park, Do-Yang
   Kim, Hyun Jun
   Kim, Chang-Hoon
   Lee, Jae Yong
   Han, Kyungdo
   Choi, Ji Ho
TI Prevalence and relationship of olfactory dysfunction and tinnitus among
   middle- and old-aged population in Korea
SO PLOS ONE
LA English
DT Article
ID NATIONAL-HEALTH; RISK-FACTORS; ANOSMIA
AB Olfactory dysfunction and tinnitus are age-related otorhinolaryngological disorders with a high prevalence in the elderly population and share several common clinical features. However, there is no study investigating the relationship between these two diseases. We studied the prevalence of olfactory dysfunction and tinnitus among Koreans and studied the relationship between these two diseases based on the Korean National Health and Nutrition Examination Survey. The subjects of this study were enrolled from the Fifth Korean National Health and Nutrition Examination Survey (2010-2012, n = 25,534). Data of subjects aged 40 years and older who underwent physical examination and completed a self-reported questionnaire and other anthropometric variables were statistically analyzed. Odds ratios were calculated to identify the relationship between olfactory dysfunction and tinnitus, using multiple logistic regression models. Older males, non-smokers, non/lower alcohol drinker groups exhibited the relationship between olfactory dysfunction and tinnitus. Metabolic syndrome and mental health problems were associated with both olfactory dysfunction and tinnitus. After adjusting for confounding factors, olfactory dysfunction was significantly associated with tinnitus (OR 1.318). There was a dose-response relationship between tinnitus severity and the odds of olfactory dysfunction (ORs for mild, moderate and severe tinnitus were, respectively, 1.134, 1.569 and 2.044). Additional molecular genetics and animal studies are needed to determine the shared pathophysiology of the two diseases.
C1 [Park, Do-Yang; Kim, Hyun Jun] Ajou Univ, Dept Otolaryngol, Sch Med, Suwon, South Korea.
   [Park, Do-Yang] Yonsei Univ, Dept Med, Grad Sch, Seoul, South Korea.
   [Kim, Chang-Hoon] Yonsei Univ, Dept Otorhinolaryngol, Coll Med, Seoul, South Korea.
   [Lee, Jae Yong; Choi, Ji Ho] Soonchunhyang Univ, Bucheon Hosp, Dept Otorhinolaryngol Head & Neck Surg, Coll Med, Bucheon, South Korea.
   [Han, Kyungdo] Catholic Univ Korea, Coll Med, Dept Biostat, Seoul, South Korea.
C3 Ajou University; Yonsei University; Yonsei University; Yonsei University
   Health System; Soonchunhyang University; Catholic University of Korea
RP Choi, JH (corresponding author), Soonchunhyang Univ, Bucheon Hosp, Dept Otorhinolaryngol Head & Neck Surg, Coll Med, Bucheon, South Korea.
EM handsomemd@hanmail.net
RI Lee, Joo Yong/ADE-2110-2022
OI Choi, Ji Ho/0000-0002-5194-930X; PARK, DO YANG/0000-0001-9969-3051
FU National Research Foundation of Korea Grant - Korean Government
   [NRF-2017R1C1B1007454]; Soonchunhyang University Research Fund
FX This work was supported by the National Research Foundation of Korea
   Grant funded by the Korean Government (NRF-2017R1C1B1007454). This study
   was supported by the Soonchunhyang University Research Fund (URL:
   http://sanhak.sch.ac.kr).The funders had no role in study design, data
   collection and analysis, decision to publish, or preparation of the
   manuscript.
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NR 30
TC 5
Z9 5
U1 2
U2 5
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD OCT 23
PY 2018
VL 13
IS 10
AR e0206328
DI 10.1371/journal.pone.0206328
PG 11
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA GX8WQ
UT WOS:000448076200047
PM 30352085
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Choi, YJ
   Shin, HS
   Choi, HS
   Park, JW
   Jo, IH
   Oh, ES
   Lee, KY
   Lee, BH
   Johnson, RJ
   Kang, DH
AF Choi, Yea-Jin
   Shin, Hyun-Soo
   Choi, Hack Sun
   Park, Joo-Won
   Jo, Inho
   Oh, Eok-Soo
   Lee, Kang-Yo
   Lee, Byung-Hoon
   Johnson, Richard J.
   Kang, Duk-Hee
TI Uric acid induces fat accumulation via generation of endoplasmic
   reticulum stress and SREBP-1c activation in hepatocytes
SO LABORATORY INVESTIGATION
LA English
DT Article
ID ELEMENT-BINDING PROTEIN-1C; LIVER-DISEASE; HEPATIC STEATOSIS; OXIDATIVE
   STRESS; ER STRESS; INSULIN-RESISTANCE; GENE-EXPRESSION; RAT-LIVER;
   GLUCOSE; MICE
AB Non-alcoholic fatty liver disease (NAFLD) is currently one of the most common types of chronic liver injury. Elevated serum uric acid is a strong predictor of the development of fatty liver as well as metabolic syndrome. Here we demonstrate that uric acid induces triglyceride accumulation by SREBP-lc activation via induction of endoplasmic reticulum (ER) stress in hepatocytes. Uric acid-induced ER stress resulted in an increase of glucose-regulated protein (GRP78194), splicing of the X-box-binding protein-1 (XBP-1), the phosphorylation of protein kinase RNA-like ER kinase (PERK), and eukaryotic translation initiation factor-2 alpha (eIF-2 alpha) in cultured hepatocytes. Uric acid promoted hepatic lipogenesis through overexpression of the lipogenic enzyme, acetyl-CoA carboxylase 1 (ACC1), fatty acid synthase (FAS), and stearoyl-CoA desaturase 1 (SCD1) via activation of SREBP-1c, which was blocked by probenecid, an organic anion transport blocker in HepG2 cells and primary hepatocytes. A blocker of ER stress, tauroursodeoxycholic acid (TUDCA), and an inhibitor of SREBP-1c, metformin, blocked hepatic fat accumulation, suggesting that uric acid promoted fat synthesis in hepatocytes via ER stress-induced activation of SREBP-1c. Uric acid-induced activation of NADPH oxidase preceded ER stress, which further induced mitochondrial ROS production in hepatocytes. These studies provide new insights into the mechanisms by which uric acid stimulates fat accumulation in the liver.
C1 [Choi, Yea-Jin; Shin, Hyun-Soo; Choi, Hack Sun; Kang, Duk-Hee] Ewha Womans Univ, Ewha Med Res Ctr, Sch Med, Dept Internal Med, Seoul 158710, South Korea.
   [Park, Joo-Won] Ewha Womans Univ, Ewha Med Res Ctr, Sch Med, Dept Biochem, Seoul 158710, South Korea.
   [Jo, Inho] Ewha Womans Univ, Ewha Med Res Ctr, Sch Med, Dept Mol Med, Seoul 158710, South Korea.
   [Oh, Eok-Soo] Ewha Womans Univ, Dept Life Sci, Div Life & Pharmaceut Sci, Seoul 158710, South Korea.
   [Lee, Kang-Yo; Lee, Byung-Hoon] Seoul Natl Univ, Coll Pharm, Seoul, South Korea.
   [Lee, Kang-Yo; Lee, Byung-Hoon] Seoul Natl Univ, Pharmaceut Sci Res Inst, Seoul, South Korea.
   [Johnson, Richard J.] Univ Colorado Denver, Div Renal Dis & Hypertens, Aurora, CO USA.
C3 Ewha Womans University; Ewha Womans University; Ewha Womans University;
   Ewha Womans University; Seoul National University (SNU); Seoul National
   University (SNU); Children's Hospital Colorado; University of Colorado
   System; University of Colorado Anschutz Medical Campus
RP Kang, DH (corresponding author), Ewha Womans Univ, Ewha Med Res Ctr, Sch Med, Div Nephrol, 911 Mok Dong, Seoul 158710, South Korea.
EM OhES@ewha.ac.kr; dhkang@ewha.ac.kr
RI Lee, Byung-Hoon/L-7490-2018; Park, JOO-WON/LRU-3013-2024; Jo,
   Inho/R-3581-2019
OI Jo, Inho/0000-0001-6060-6416; Kang, Duk-Hee/0000-0001-8475-8932
FU Korea Healthcare Technology RD Project; Ministry for Health, Welfare
   Family Affairs; Republic of Korea [A101742]; National Research
   Foundation of Korea (NRF) - Korea Government (MEST) [2010-0019866,
   2012R1A2A2A01013541]; Seoul Scholarship Foundation; Ewha Global Top 5
   Grant of Ewha Womans University
FX This study was supported by the grant from the Korea Healthcare
   Technology R&D Project, Ministry for Health, Welfare & Family Affairs,
   Republic of Korea (A101742), the National Research Foundation of Korea
   (NRF) grant funded by the Korea Government (MEST) (2010-0019866,
   2012R1A2A2A01013541), Hi Seoul Science (Humanities) Fellowship funded by
   Seoul Scholarship Foundation, and the Ewha Global Top 5 Grant 2013 of
   Ewha Womans University.
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NR 31
TC 208
Z9 231
U1 3
U2 33
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 0023-6837
EI 1530-0307
J9 LAB INVEST
JI Lab. Invest.
PD OCT
PY 2014
VL 94
IS 10
BP 1114
EP 1125
DI 10.1038/labinvest.2014.98
PG 12
WC Medicine, Research & Experimental; Pathology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pathology
GA AQ0NW
UT WOS:000342481000005
PM 25111690
OA Bronze
DA 2025-06-11
ER

PT J
AU Corona, G
   Mannucci, E
   Jannini, EA
   Lotti, F
   Ricca, V
   Monami, M
   Boddi, V
   Bandini, E
   Balercia, G
   Forti, G
   Maggi, M
AF Corona, Giovanni
   Mannucci, Edoardo
   Jannini, Emmanuele A.
   Lotti, Francesco
   Ricca, Valdo
   Monami, Matteo
   Boddi, Valentina
   Bandini, Elisa
   Balercia, Giancarlo
   Forti, Gianni
   Maggi, Mario
TI Hypoprolactinemia: A New Clinical Syndrome in Patients with Sexual
   Dysfunction
SO JOURNAL OF SEXUAL MEDICINE
LA English
DT Article
DE Hypoprolactinemia; Sexual Dysfunction; Erectile Dysfunction; SIEDY
ID CENTRAL SEROTONERGIC RESPONSIVITY; INDUCED DIABETIC-RATS; ERECTILE
   DYSFUNCTION; METABOLIC SYNDROME; PREMATURE EJACULATION;
   ANTERIOR-PITUITARY; TRANSPORTER GENE; PROLACTIN; HYPERPROLACTINEMIA;
   DISORDERS
AB The physiological role of prolactin (PRL) in male sexual behavior is poorly understood. Conversely, the association between PRL pathological elevation in both reproductive and sexual behavior is well defined.
   The aim of the present study is to assess the correlates of normal PRL (PRL < 735 mU/L or 35 ng/mL), in male subjects consulting for sexual dysfunction.
   A consecutive series of 2,531 (mean age 52.0 +/- 12.9 years) subjects was investigated. Patients were interviewed using the structured interview on erectile dysfunction (SIEDY), a 13-item tool for the assessment of erectile dysfunction (ED)-related morbidities. Middlesex Hospital Questionnaire was used for the evaluation of psychological symptoms.
   Several hormonal (testosterone, thyroid stimulation hormone, and PRL) and biochemical parameters (glycemia and lipid profile) were studied, along with penile Doppler ultrasound (PDU) and SIEDY items.
   After adjustment for confounders anxiety symptoms decreased across PRL quartiles (I: < 113 mU/L or 5 ng/mL; II: 113-156 mU/L or 5.1-7 ng/mL; III: 157-229 mU/L or 7.1-11 ng/mL; IV: 229-734 mU/L or 11.1-34.9 ng/mL). Patients in the lowest PRL quartile showed a higher risk of metabolic syndrome (MetS; odds ratio [OR] = 1.74 [1.01-2.99], P < 0.05), arteriogenic ED (peak systolic velocity at PDU < 35 cm/sec; OR = 1.43 [1.01-2.03], P < 0.05), and premature ejaculation (PE; OR = 1.38 [1.02-1.85]; P < 0.05). Conversely, comparing subjects with PRL-secreting pituitary adenomas (N = 13) with matched controls, no significant difference was observed, except for a higher prevalence of hypoactive sexual desire in hyperprolactinemia.
   Our findings demonstrate that, in subjects consulting for sexual dysfunction, PRL in the lowest quartile levels are associated with MetS and arteriogenic ED, as well as with PE and anxiety symptoms. Further studies are advisable in order to confirm our preliminary results in different populations. Corona G, Mannucci E, Jannini EA, Lotti F, Ricca V, Monami M, Boddi V, Bandini E, Balercia G, Forti G, and Maggi M. Hypoprolactinemia: A new clinical syndrome in patients with sexual dysfunction. J Sex Med 2009;6:1457-1466.
C1 [Corona, Giovanni; Lotti, Francesco; Boddi, Valentina; Bandini, Elisa; Forti, Gianni; Maggi, Mario] Univ Florence, Dept Clin Physiopathol, Androl Unit, I-50139 Florence, Italy.
   [Mannucci, Edoardo; Monami, Matteo] Univ Florence, Dept Crit Care, Diabet Sect, Geriatr Unit, I-50139 Florence, Italy.
   [Jannini, Emmanuele A.] Univ Aquila, Dept Expt Med, Sch Sexol, I-67100 Laquila, Italy.
   [Ricca, Valdo] Univ Florence, Dept Neurol & Psychiat Sci, Psychiat Unit, I-50139 Florence, Italy.
   [Balercia, Giancarlo] Polytech Univ Marche, Endocrinol Unit, Ancona, Italy.
   [Corona, Giovanni] Maggiore Bellaria Hosp, Endocrinol Unit, Bologna, Italy.
C3 University of Florence; University of Florence; University of L'Aquila;
   University of Florence; Marche Polytechnic University; AUSL di Bologna
RP Maggi, M (corresponding author), Univ Florence, Dept Clin Physiopathol, Androl Unit, Viale Pieraccini 6, I-50139 Florence, Italy.
EM m.maggi@dfc.unifi.it
RI Monami, Matteo/L-4074-2019; Lotti, Francesco/AAC-3186-2019; Maggi,
   Mario/AAB-8284-2019; ricca, valdo/K-8382-2012; Mannucci,
   Edoardo/K-6749-2016; LOTTI, Francesco/K-1801-2018
OI Mannucci, Edoardo/0000-0001-9759-9408; LOTTI,
   Francesco/0000-0001-8343-1807; Jannini, Emmanuele
   A./0000-0002-5874-039X; MAGGI, Mario/0000-0003-3267-4221; ricca,
   valdo/0000-0002-9291-2124
FU University of Florence
FX We would like to thank Angela Magini, Riccardo Mansani, Csilla Krausz,
   and Luisa Petrone of the Andrology Unit of the University of Florence.
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NR 43
TC 134
Z9 142
U1 0
U2 20
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1743-6095
EI 1743-6109
J9 J SEX MED
JI J. Sex. Med.
PD MAY
PY 2009
VL 6
IS 5
BP 1457
EP 1466
DI 10.1111/j.1743-6109.2008.01206.x
PG 10
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 438LI
UT WOS:000265556500028
PM 19210705
DA 2025-06-11
ER

PT J
AU Meng, FXZ
   Liu, ZC
   Qin, SC
   Liu, BY
AF Meng, Fanxianzi
   Liu, Zhichao
   Qin, Shucun
   Liu, Boyan
TI Oral Administration of Hydrogen-rich Water: Biomedical Activities,
   Potential Mechanisms, and Clinical Applications
SO CURRENT PHARMACEUTICAL DESIGN
LA English
DT Review
DE Hydrogen-rich water; molecular hydrogen; reactive oxygen species;
   oxidative stress; inflammation; clinical trials
ID ALKALINE ELECTROLYZED WATER; MOLECULAR-HYDROGEN; METABOLIC SYNDROME;
   OXIDATIVE STRESS; LIVER-FUNCTION; REDUCED WATER; ANTIOXIDANT; DISEASE;
   SUPPLEMENTATION; CONSUMPTION
AB Molecular hydrogen (H2) is considered a biological antioxidant. Hydrogen-rich Water (HRW) is regular water that contains dissolved H2 and has become more widely used in recent years. This review summarizes the basic research and clinical applications of HRW consumption to support its use for daily health and clinical treatment. The biological effects of HRW include reducing oxidative stress, exerting anti-inflammatory effects, regulating glucose and lipid metabolism, protecting mitochondrial function, and regulating apoptosis. Hypotheses about the mechanisms of H2 include the direct scavenging of toxic free radicals, the Fe-porphyrin biosensor hypothesis, the effect of H2 on biological enzymes, the lipoprotein regulation of H2, and H2 acting on the intestinal barrier. Clinically, HRW has been used for adjuvant treatment, disease prevention, and quality of life improvement. In the future, more in-depth studies and large-scale clinical trials are needed.
C1 [Meng, Fanxianzi; Liu, Zhichao; Qin, Shucun; Liu, Boyan] Shandong First Med Univ, Affiliated Hosp 2, Shandong Prov Key Med & Hlth Lab Hydrogen Biomed R, Tai An, Peoples R China.
   [Meng, Fanxianzi; Liu, Zhichao; Qin, Shucun; Liu, Boyan] Shandong First Med Univ, Affiliated Hosp 2, Taishan Inst Hydrogen Biomed Res, Key Lab Major Dis & Hydrogen Med Translat Applicat, Tai An, Peoples R China.
RP Qin, SC; Liu, BY (corresponding author), Shandong First Med Univ, Affiliated Hosp 2, Shandong Prov Key Med & Hlth Lab Hydrogen Biomed R, Tai An, Peoples R China.; Qin, SC; Liu, BY (corresponding author), Shandong First Med Univ, Affiliated Hosp 2, Taishan Inst Hydrogen Biomed Res, Key Lab Major Dis & Hydrogen Med Translat Applicat, Tai An, Peoples R China.
EM byliu@sdfmu.edu.cn; scqin@sdfmu.edu.cn
FU National Natural Science Foundation of China [82200508]; Science and
   Technology Support Plan for Youth Innovation Team of Universities in
   Shandong Province [2023KJ184]; Shandong Provincial Natural Science
   Foundation [ZR2020QH020]; Academic Promotion Program of Shandong First
   Medical University [2019QL010]
FX This research work was supported by the National Natural Science
   Foundation of China (82200508), Science and Technology Support Plan for
   Youth Innovation Team of Universities in Shandong Province (2023KJ184),
   Shandong Provincial Natural Science Foundation (ZR2020QH020), and
   Academic Promotion Program of Shandong First Medical University
   (2019QL010).
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NR 102
TC 0
Z9 0
U1 3
U2 3
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1381-6128
EI 1873-4286
J9 CURR PHARM DESIGN
JI Curr. Pharm. Design
PY 2025
VL 31
IS 19
BP 1537
EP 1550
DI 10.2174/0113816128330516241121150719
PG 14
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 2VH8U
UT WOS:001492174700003
PM 39810534
DA 2025-06-11
ER

PT J
AU Ahmad, I
   Imran, M
   Noreen, S
   Farwa, U
   Riaz, M
   Javaid, S
   Aslam, M
   Tahir, M
   Niazi, MN
   Safdar, S
   Hassan, M
AF Ahmad, Ishtiaque
   Imran, Muhammad
   Noreen, Sana
   Farwa, Umme
   Riaz, Mishal
   Javaid, Shehla
   Aslam, Mahwish
   Tahir, Maham
   Niazi, Madiha Naveed
   Safdar, Sadaf
   Hassan, Mashal
TI Hydroxytyrosol: A comprehensive approach to Mitigate Maladies
SO BIOSCIENCE RESEARCH
LA English
DT Review
DE Olive oil; hydroxytyrosol; polyphenol; cancer; anti-diabetic
ID OLIVE LEAF EXTRACT; CELL-CYCLE ARREST; OXIDATIVE STRESS; ANTIOXIDANT
   ACTIVITY; METABOLIC SYNDROME; PHENOLIC-COMPOUNDS; NATURAL MOLECULE;
   TUMOR-GROWTH; OIL PHENOLS; IN-VIVO
AB The olive oil has been found essential part of human daily diet with a healthy way of eating and living nowadays. Oilve tree is promising source of phytochemicals such as hydroxytyrosol, oleocanthal, tyrosol, oleuropein, and oleacein along with numerous health endorsing perspectives in an invitro and in vivo studies such as prevention from cancer insurgence, diabetes, obesity, oxidative stress, microbial contamination and cardiac complications, respectively. In this regard, hydroxytyrosol inhibited the cancer proliferation stages such as cell growth, invasion and proliferation. It also lowered the expressions of nuclear factor kappa B (NF-kappa B), Akt and signal transducer and transcript 3 activator (STAT3). It also reduces the oxidative, & nitrosative stress, and brain inflammatory mediators with decreasing the TBARS level, neutralizing the free radicals, decreasing the higher glucose level, and increasing the insulin sensitivity. The current review article highlights the absorption and metabolism of hydroxytyrosol, in addition pharmacological potential, further studies are still required.
C1 [Ahmad, Ishtiaque; Aslam, Mahwish] Univ Vet & Anim Sci, Dept Dairy Technol, Lahore 54000, Pakistan.
   [Imran, Muhammad; Noreen, Sana; Farwa, Umme; Riaz, Mishal; Tahir, Maham; Niazi, Madiha Naveed; Safdar, Sadaf; Hassan, Mashal] Univ Lahore, Univ Inst Diet & Nutrit Sci, Lahore, Pakistan.
   [Javaid, Shehla] Univ Lahore, Univ Inst Med Lab Technol, Lahore, Pakistan.
C3 University of Veterinary & Animal Science - Pakistan; University of
   Lahore; University of Lahore
RP Noreen, S (corresponding author), Univ Lahore, Univ Inst Diet & Nutrit Sci, Lahore, Pakistan.
EM sananoreen.rizwan@gmail.com
RI NOREEN, SANA/AAN-7542-2021; Imran, Muhammad/JEF-6364-2023; Safdar,
   Sadaf/KRQ-3393-2024; Ahmad, Dr. Ishtiaque/AAC-9252-2020
OI Ahmad, Dr. Ishtiaque/0000-0002-1117-3703
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NR 84
TC 0
Z9 0
U1 1
U2 8
PU INNOVATIVE SCIENTIFIC INFORMATION & SERVICES NETWORK
PI FAISALABAD
PA INNOVATIVE SCIENTIFIC INFORMATION & SERVICES NETWORK, FAISALABAD, 00000,
   PAKISTAN
SN 1811-9506
EI 2218-3973
J9 BIOSCI RES
JI Biosci. Res.
PD OCT-DEC
PY 2021
VL 18
IS 4
BP 2811
EP 2821
PG 11
WC Biology
WE Emerging Sources Citation Index (ESCI)
SC Life Sciences & Biomedicine - Other Topics
GA YI6MH
UT WOS:000743960200030
DA 2025-06-11
ER

PT J
AU DeMarco, VG
   Johnson, MS
   Whaley-Connell, AT
   Sowers, JR
AF DeMarco, Vincent G.
   Johnson, Megan S.
   Whaley-Connell, Adam T.
   Sowers, James R.
TI Cytokine Abnormalities in the Etiology of the Cardiometabolic Syndrome
SO CURRENT HYPERTENSION REPORTS
LA English
DT Article
DE Metabolic syndrome; CMS; Hypertension; Adipokines; Oxidative stress;
   Insulin resistance
ID REVERSES INSULIN-RESISTANCE; COMPLEMENT-RELATED PROTEIN; ADIPOSE-TISSUE;
   WEIGHT-LOSS; DIABETES-MELLITUS; ADIPONECTIN; OBESITY; MUSCLE; FAT;
   HYPERTENSION
AB The cardiometabolic syndrome comprises a cluster of risk factors, including abdominal obesity, dyslipidemia, hypertension, insulin resistance/glucose intolerance, and proteinuria. This syndrome is due, in part, to the accumulation of visceral fat, which promotes synthesis of proinflammatory adipokines resulting in a visceral adipose tissue-specific increase in reactive oxygen species derived from NADPH oxidase. Adipose tissue oxidative stress results in the development of systemic oxidative stress and inflammation, which further lead to development of metabolic dyslipidemia, impaired glucose metabolism, renal disease, and hypertension. Importantly, visceral-not subcutaneous-fat is the significant source of the circulating adipokines that promote these systemic abnormalities. Chronic low-grade inflammation develops within adipose tissue because of the additional infiltration and accumulation of inflammatory macrophages. There is evidence that lifestyle changes, bariatric surgery, and/or administration of insulin-sensitizing, anti-inflammatory, or antihypertensive drugs that address the risk factors promoting the cardiometabolic syndrome act, in part, by promoting an anti-inflammatory adipokine profile in visceral fat.
C1 [DeMarco, Vincent G.; Johnson, Megan S.; Whaley-Connell, Adam T.; Sowers, James R.] Univ Missouri, Diabet & Cardiovasc Ctr Excellence, Columbia, MO 65212 USA.
C3 University of Missouri System; University of Missouri Columbia
RP Sowers, JR (corresponding author), Univ Missouri, Diabet & Cardiovasc Ctr Excellence, 1 Hosp Dr, Columbia, MO 65212 USA.
EM demarcov@missouri.edu; johnsonm@missouri.edu;
   whaleyconnella@missouri.edu; sowersj@health.missouri.edu
OI Whaley-Connell, Adam/0000-0001-8955-5560; DeMarco,
   Vincent/0000-0003-2092-9995
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NR 54
TC 39
Z9 40
U1 0
U2 6
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1522-6417
EI 1534-3111
J9 CURR HYPERTENS REP
JI Curr. Hypertens. Rep.
PD APR
PY 2010
VL 12
IS 2
BP 93
EP 98
DI 10.1007/s11906-010-0095-5
PG 6
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 596XR
UT WOS:000277719600008
PM 20424939
DA 2025-06-11
ER

PT J
AU Kvandová, M
   Majzúnová, M
   Dovinová, I
AF Kvandova, M.
   Majzunova, M.
   Dovinova, I.
TI The Role of PPARγ in Cardiovascular Diseases
SO PHYSIOLOGICAL RESEARCH
LA English
DT Review
DE PPAR gamma; Hypertension; Oxidative stress; Antioxidant response;
   Renin-angiotensin system; Nitric oxide
ID ACTIVATED-RECEPTOR-GAMMA; VASCULAR SMOOTH-MUSCLE; ROSTRAL VENTROLATERAL
   MEDULLA; NITRIC-OXIDE SYNTHASE; KINASE-MEDIATED PHOSPHORYLATION;
   ANGIOTENSIN-CONVERTING ENZYME; PROTEIN-COUPLED RECEPTORS; II TYPE-1
   RECEPTOR; BLOOD-PRESSURE; OXIDATIVE STRESS
AB The peroxisome proliferator-activated receptors (PPAR) belong to the nuclear superfamily of ligand-activated transcription factors. PPAR. acts as a nutrient sensor that regulates several homeostatic functions. Its disruption can lead to vascular pathologies, disorders of fatty acid/lipid metabolism and insulin resistance. PPAR. can modulate several signaling pathways connected with blood pressure regulation. Firstly, it affects the insulin signaling pathway and endothelial dysfunction by modulation of expression and/or phosphorylation of signaling molecules through the PI3K/Akt/eNOS or MAPK/ET-1 pathways. Secondly, it can modulate gene expression of the renin-angiotensin system -cascade proteins, which potentially slow down the progression of atherosclerosis and hypertension. Thirdly, it can modulate oxidative stress response either directly through PPAR or indirectly through Nrf2 activation. In this context, activation and functioning of PPAR. is very important in the regulation of several disorders such as diabetes mellitus, hypertension and/or metabolic syndrome.
C1 [Kvandova, M.; Majzunova, M.; Dovinova, I.] Slovak Acad Sci, Inst Normal & Pathol Physiol, Sienkiewiczova 1, Bratislava 81371, Slovakia.
C3 Slovak Academy of Sciences; Institute of Normal & Pathological
   Physiology, SAS
RP Dovinová, I (corresponding author), Slovak Acad Sci, Inst Normal & Pathol Physiol, Sienkiewiczova 1, Bratislava 81371, Slovakia.
EM ima.dovinova@savba.sk
RI Dovinova, Ima/F-2449-2018; Majzunova, Miroslava/JCE-6584-2023
OI Kvandova, Miroslava/0000-0002-7741-8283; DOVINOVA,
   IMA/0000-0001-9840-1950; Majzunova, Miroslava/0000-0001-8748-4279
FU  [APVV-0348-12];  [VEGA02/0129/14]
FX Supported by APVV-0348-12 and VEGA02/0129/14.
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NR 173
TC 84
Z9 90
U1 1
U2 24
PU ACAD SCIENCES CZECH REPUBLIC, INST PHYSIOLOGY
PI PRAGUE 4
PA VIDENSKA 1083, PRAGUE 4 142 20, CZECH REPUBLIC
SN 0862-8408
EI 1802-9973
J9 PHYSIOL RES
JI Physiol. Res.
PY 2016
VL 65
SU 3
BP S343
EP S363
DI 10.33549/physiolres.933439
PG 21
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA EA5UK
UT WOS:000386689100005
PM 27775420
OA gold
DA 2025-06-11
ER

PT J
AU Wang, F
   Yuan, CD
   Wang, XF
   Cao, JW
   Gao, XW
   Wang, YF
   Han, FL
   Qian, QH
   Shao, ZG
AF Wang, Fei
   Yuan, Chendi
   Wang, Xuefei
   Cao, Jiawen
   Gao, Xiaowen
   Wang, Yifei
   Han, Fulong
   Qian, Qiaohui
   Shao, Zeguo
TI ANALYSIS OF RISK FACTORS FOR THYROID NODULES AND STUDY ON THEIR
   ASSOCIATION WITH DIABETES AND STROKE
SO JOURNAL OF MECHANICS IN MEDICINE AND BIOLOGY
LA English
DT Article
DE Thyroid nodules; diabetes; stroke; risk factors; association analysis
AB To explore the risk factors for thyroid nodules and their correlation with diabetes and stroke, the authors conducted a study on 1000 patients with metabolic syndrome (MS). The analysis included variables such as gender, age, familial thyroid disease, salt intake, iodine intake, smoking, alcohol consumption, sleep quality, mental stress, exercise, BMI, blood pressure, diabetes, and baseline nodules. The Apriori algorithm of machine learning was used to derive 12 association rules (confidence >= 0.5), and the decision tree algorithm was used to derive 20 effective knowledge rules. The results showed that iodine intake, salt intake, BMI, and advanced age were high-risk factors for thyroid nodules. Exercise, BMI, and age were strongly correlated, while exercise, mental stress, iodine intake, and salt intake showed a strong correlation. Exercise, sleep, smoking, and alcohol consumption influenced mental stress, while age, diseases (diabetes, hypertension, obesity), and lifestyle habits influenced sleep quality. The risk of diabetes and stroke increased in patients with thyroid nodules, and there was a strong correlation among diabetes, stroke, and thyroid nodules.
C1 [Wang, Fei; Yuan, Chendi; Wang, Xuefei] Univ Shanghai Sci & Technol, Sch Hlth Sci & Engn, Shanghai 200093, Peoples R China.
   [Cao, Jiawen] Shanghai Inst Technol, Sch Mech Engn, Shanghai 201418, Peoples R China.
   [Gao, Xiaowen; Wang, Yifei; Han, Fulong] Shanghai Univ Med & Hlth Sci, Sch Mech Engn, Shanghai 201318, Peoples R China.
   [Qian, Qiaohui] Shanghai Univ Med & Hlth Sci, Affliated Zhoupu Hosp, Shanghai 201318, Peoples R China.
   [Shao, Zeguo] Shanghai Univ Med & Hlth Sci, Affiliated Zhoupu Hosp, Sch Mech Engn, Shanghai 201318, Peoples R China.
C3 University of Shanghai for Science & Technology; Shanghai Institute of
   Technology; Shanghai University of Medicine & Health Sciences; Shanghai
   University of Medicine & Health Sciences; Shanghai University of
   Medicine & Health Sciences
RP Qian, QH (corresponding author), Shanghai Univ Med & Hlth Sci, Affliated Zhoupu Hosp, Shanghai 201318, Peoples R China.; Shao, ZG (corresponding author), Shanghai Univ Med & Hlth Sci, Affiliated Zhoupu Hosp, Sch Mech Engn, Shanghai 201318, Peoples R China.
EM 1711960437@qq.com; 1004527491@qq.com; 18115859631@163.com;
   2602430386@qq.com; gxw.2002@qq.com; 784357236@qq.com; 3588831317@qq.com;
   18917684029@189.cn; zeguoshao@fudan.edu.cn
RI Shao, Zeguo/AAB-2677-2020; Yuan, chendi/HNB-9965-2023; c,
   jiawen/KFA-3371-2024; Wang, Fei/HSI-3141-2023; qian,
   qiaohui/LVS-5036-2024; Wang, Xuefei/HCI-5764-2022
OI shao, zeguo/0000-0003-4313-8758
FU 2020 National Social Science Fund [20BTQ073]; Shanghai Pudong New Area
   Science and Technology Development Fund Public Institution Livelihood
   Research Special [PKJ2021-Y32]
FX This research was funded by the 2020 National Social Science Fund, grant
   number 20BTQ073 and Shanghai Pudong New Area Science and Technology
   Development Fund Public Institution Livelihood Research Special (Medical
   and Health) Project, grant number PKJ2021-Y32.
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NR 27
TC 0
Z9 0
U1 3
U2 22
PU WORLD SCIENTIFIC PUBL CO PTE LTD
PI SINGAPORE
PA 5 TOH TUCK LINK, SINGAPORE 596224, SINGAPORE
SN 0219-5194
EI 1793-6810
J9 J MECH MED BIOL
JI J. Mech. Med. Biol.
PD NOV
PY 2023
VL 23
IS 09
DI 10.1142/S0219519423401048
EA OCT 2023
PG 17
WC Biophysics; Engineering, Biomedical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biophysics; Engineering
GA AE7C3
UT WOS:001080651400002
DA 2025-06-11
ER

PT J
AU Sun, WP
   Zhai, MZ
   Zhou, Q
   Qian, CR
   Jiang, CY
AF Sun, Wuping
   Zhai, Mingzhu
   Zhou, Qian
   Qian, Chengrui
   Jiang, Changyu
TI Effects of B Vitamins Overload on Plasma Insulin Level and Hydrogen
   Peroxide Generation in Rats
SO CHINESE JOURNAL OF PHYSIOLOGY
LA English
DT Article
DE B vitamins; insulin resistance; nicotinamide; nicotinic acid; oxidative
   stress
ID METABOLIC SYNDROME; NICOTINAMIDE; GLUCOSE; OBESITY; DIET;
   N-1-METHYLNICOTINAMIDE; POPULATION; PREVALENCE; EXPRESSION; SAFETY
AB It has been reported that nicotinamide-overload induces oxidative stress associated with insulin resistance, the key feature of type 2 diabetes mellitus (T2DM). This study aimed to investigate the effects of B vitamins in T2DM. Glucose tolerance tests (GTT) were carried out in adult Sprague-Dawley rats treated with or without cumulative doses of B vitamins. More specifically, insulin tolerance tests (ITT) were also carried out in adult Sprague-Dawley rats treated with or without cumulative doses of Vitamin B3. We found that cumulative Vitamin B1 and Vitamin B3 administration significantly increased the plasma H2O2 levels associated with high insulin levels. Only Vitamin B3 reduced muscular and hepatic glycogen contents. Cumulative administration of nicotinic acid, another form of Vitamin B3, also significantly increased plasma insulin level and 14202 generation. Moreover, cumulative administration of nicotinic acid or nicotinamide impaired glucose metabolism. This study suggested that excess Vitamin B1 and Vitamin B3 caused oxidative stress and insulin resistance.
C1 [Sun, Wuping; Zhou, Qian; Qian, Chengrui; Jiang, Changyu] Shenzhen Univ, Shenzhen Municipal Peoples Hosp 6, Dept Pain Med, Affiliated Nanshan Peoples Hosp, Shenzhen 518060, Peoples R China.
   [Zhai, Mingzhu] IST Austria, Campus 1, A-3400 Klosterneuburg, Austria.
C3 Shenzhen University; Institute of Science & Technology - Austria
RP Sun, WP (corresponding author), Shenzhen Univ, Shenzhen Municipal Peoples Hosp 6, Dept Pain Med, Affiliated Nanshan Peoples Hosp, Shenzhen 518060, Peoples R China.
EM wuping.sun@foxmail.com
RI Zhai, Mingzhu/KGK-9927-2024; jiang, changyu/D-7547-2015; zhou,
   qian/HSG-2858-2023; Sun, Wuping/A-4492-2015
OI Zhai, Mingzhu/0000-0003-4694-4368
FU Shenzhen Municipal Science, Technology and Innovation Commission
   [JCYJ20160429182122843, JCYJ20160429181451546]; Municipal Key Laboratory
   Program of Shenzhen [ZD-SYS20140509150415945]
FX This work was supported by grants from Shenzhen Municipal Science,
   Technology and Innovation Commission (No. JCYJ20160429182122843, No.
   JCYJ20160429181451546), Municipal Key Laboratory Program of Shenzhen
   (No. ZD-SYS20140509150415945).
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NR 30
TC 3
Z9 4
U1 0
U2 8
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, 400059, INDIA
SN 0304-4920
EI 2666-0059
J9 CHINESE J PHYSIOL
JI Chin. J. Physiol.
PD AUG 31
PY 2017
VL 60
IS 4
BP 207
EP 214
DI 10.4077/CJP.2017.BAF469
PG 8
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA FG1OT
UT WOS:000409566300002
PM 28847140
DA 2025-06-11
ER

PT J
AU Luo, ZC
   Bilodeau, JF
   Nuyt, AM
   Fraser, WD
   Julien, P
   Audibert, F
   Xiao, L
   Garofalo, C
   Levy, E
AF Luo, Zhong-Cheng
   Bilodeau, Jean-Francois
   Nuyt, Anne Monique
   Fraser, William D.
   Julien, Pierre
   Audibert, Francois
   Xiao, Lin
   Garofalo, Carole
   Levy, Emile
TI Perinatal Oxidative Stress May Affect Fetal Ghrelin Levels in Humans
SO SCIENTIFIC REPORTS
LA English
DT Article
ID GLUCOSE-TOLERANCE; INSULIN-SECRETION; GROWTH; BIRTH; F-2-ISOPROSTANES;
   RECEPTOR; MARKERS; LEPTIN; PLASMA; BLOOD
AB In vitro cell model studies have shown that oxidative stress may affect beta-cell function. It is unknown whether oxidative stress may affect metabolic health in human fetuses/newborns. In a singleton pregnancy cohort (n = 248), we studied maternal (24-28 weeks gestation) and cord plasma biomarkers of oxidative stress [malondialdehyde (MDA), F2-isoprostanes] in relation to fetal metabolic health biomarkers including cord plasma glucose-to-insulin ratio (an indicator of insulin sensitivity), proinsulin-to-insulin ratio (an indicator of beta-cell function), insulin, IGF-I, IGF-II, leptin, adiponectin and ghrelin concentrations. Strong positive correlations were observed between maternal and cord plasma biomarkers of oxidative stress (r = 0.33 for MDA, r = 0.74 for total F2-isoprostanes, all p < 0.0001). Adjusting for gestational age at blood sampling, cord plasma ghrelin concentrations were consistently negatively correlated to oxidative stress biomarkers in maternal (r = -0.32, p < 0.0001 for MDA; r = -0.31, p < 0.0001 for F2-isoprostanes) or cord plasma (r = -0.13, p = 0.04 for MDA; r = -0.32, p < 0.0001 for F2-isoprostanes). Other fetal metabolic health biomarkers were not correlated to oxidative stress. Adjusting for maternal and pregnancy characteristics, similar associations were observed. Our study provides the first preliminary evidence suggesting that oxidative stress may affect fetal ghrelin levels in humans. The implications in developmental "programming" the vulnerability to metabolic syndrome related disorders remain to be elucidated.
C1 [Luo, Zhong-Cheng] Shanghai Jiao Tong Univ, Sch Med, Shanghai Key Lab Childrens Environm Hlth, Minist Educ,Xinhua Hosp, Shanghai 200092, Peoples R China.
   [Luo, Zhong-Cheng; Nuyt, Anne Monique; Audibert, Francois; Xiao, Lin] Univ Montreal, Dept Obstet & Gynecol, Montreal, PQ H3T 1C5, Canada.
   [Luo, Zhong-Cheng; Audibert, Francois; Xiao, Lin] Univ Montreal, Dept Pediat, Montreal, PQ H3T 1C5, Canada.
   [Bilodeau, Jean-Francois] Med Univ Montreal, Dept Obstet, Montreal, PQ H3T 1C5, Canada.
   [Bilodeau, Jean-Francois] Med Univ Montreal, Dept Gynecol, Montreal, PQ H3T 1C5, Canada.
   [Bilodeau, Jean-Francois] Med Univ Montreal, Dept Reprod Med, Montreal, PQ H3T 1C5, Canada.
   [Nuyt, Anne Monique] Univ Montreal, Dept Nutr, Montreal, PQ H3T 1C5, Canada.
   [Garofalo, Carole; Levy, Emile] Univ Montreal, Hop St Justine, Res Ctr, Dept Obstet, Montreal, PQ H3T 1C5, Canada.
   [Garofalo, Carole; Levy, Emile] Univ Montreal, Hop St Justine, Res Ctr, Dept Gynecol, Montreal, PQ H3T 1C5, Canada.
   [Julien, Pierre] Dept Obstet & Gynecol, Quebec City, PQ G1V 4G2, Canada.
   [Julien, Pierre] Dept Mol & Oncol Endocrinol, Quebec City, PQ G1V 4G2, Canada.
   [Julien, Pierre] Human Genom Res Ctr, Quebec City, PQ G1V 4G2, Canada.
   [Julien, Pierre] Univ Laval, Univ Hosp, Res Ctr, Dept Obstet, Quebec City, PQ G1V 4G2, Canada.
   [Julien, Pierre] Univ Laval, Univ Hosp, Res Ctr, Dept Gynecol, Quebec City, PQ G1V 4G2, Canada.
   [Fraser, William D.] Univ Sherbrooke, Dept Obstet & Gynecol, Sherbrooke, PQ J1H 5N4, Canada.
C3 Shanghai Jiao Tong University; Ministry of Education - China; Universite
   de Montreal; Universite de Montreal; Universite de Montreal; Universite
   de Montreal; Universite de Montreal; Laval University; University of
   Quebec; Laval University; University of Quebec; University of Sherbrooke
RP Luo, ZC (corresponding author), Shanghai Jiao Tong Univ, Sch Med, Shanghai Key Lab Childrens Environm Hlth, Minist Educ,Xinhua Hosp, Shanghai 200092, Peoples R China.
EM zhongcheng_luo3@163.com; emile.levy@recherche-ste-justine.qc.ca
RI Bilodeau, Jean-François/B-1712-2013; Audibert, François/AAL-1265-2020;
   Julien, Pierre/AGO-7542-2022; LUO, Zhong-Cheng/T-3882-2017
OI Audibert, Francois/0000-0002-2697-3826; Bilodeau,
   Jean-Francois/0000-0001-9427-5387; LUO, Zhong-Cheng/0000-0002-1794-1312
FU Canadian Institutes of Health Research (CIHR) [79896, 78879, 88055];
   National Natural Science Foundation of China [81370742]
FX We would like to acknowledge the excellent professional work of research
   staff at Sainte-Justine Hospital Research Center in patient recruitment,
   follow-ups, data management and biochemical assays. This study was
   supported by research grants from the Canadian Institutes of Health
   Research (CIHR grant # 79896, #78879 and # 88055) and National Natural
   Science Foundation of China (grant # 81370742).
CR Agarwal A, 2005, REPROD BIOL ENDOCRIN, V3, DOI 10.1186/1477-7827-3-28
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NR 36
TC 11
Z9 11
U1 1
U2 9
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD DEC 8
PY 2015
VL 5
AR 17881
DI 10.1038/srep17881
PG 7
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA CX8OK
UT WOS:000365963100001
PM 26643495
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Maeyama, H
   Hirasawa, T
   Tahara, Y
   Obata, C
   Kasai, H
   Moriishi, K
   Mochizuki, K
   Kubota, T
AF Maeyama, H.
   Hirasawa, T.
   Tahara, Y.
   Obata, C.
   Kasai, H.
   Moriishi, K.
   Mochizuki, K.
   Kubota, T.
TI Maternal restraint stress during pregnancy in mice induces
   11β-HSD1-associated metabolic changes in the livers of the offspring
SO JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE
LA English
DT Article
DE fatty liver; metabolic syndrome; pregnancy; restraint stress; 11
   beta-HSD1
ID 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1; INTRAUTERINE GROWTH
   RESTRICTION; PRENATAL STRESS; FATTY LIVER; DEVELOPMENTAL ORIGINS;
   INSULIN SENSITIVITY; VISCERAL OBESITY; MESSENGER-RNA; RATS; DISEASE
AB In rats, maternal exposure to restraint stress during pregnancy can induce abnormalities in the cardiovascular and central nervous systems of the offspring. These effects are mediated by long-lasting hyperactivation of the hypothalamic-pituitary-adrenal axis. However, little is known about the potential effects of stress during pregnancy on metabolic systems. We examined the effect of restraint stress in pregnant mice on the liver function of their offspring. The offspring of stressed mothers showed significantly higher lipid accumulation in the liver after weaning than did the controls; this accumulation was associated with increased expression of lipid metabolism-related proteins such as alanine aminotransferase 2 diglyceride acyltransferase 1, peroxisome proliferator-activated receptor gamma and glucocorticoid receptor. Additionally, we observed increased levels of 11 beta-hydroxysteroid dehydrogenase type 1, an intercellular mediator that converts glucocorticoid from the inactive to the active form, in the foetal and postnatal periods. These results indicate that restraint stress in pregnancy in mice induces metabolic abnormalities via 11 beta-hydroxysteroid dehydrogenase type 1-related pathways in the foetal liver. It is therefore possible that exposure to stress in pregnant women may be a risk factor for metabolic syndromes (e.g. fatty liver) in children.
C1 [Maeyama, H.; Hirasawa, T.; Tahara, Y.; Obata, C.; Kubota, T.] Univ Yamanashi, Dept Epigenet Med, Yamanashi 4093898, Japan.
   [Kasai, H.; Moriishi, K.] Univ Yamanashi, Dept Microbiol, Chuo Ku, Yamanashi 4093898, Japan.
   [Mochizuki, K.] Univ Yamanashi, Fac Life & Environm Sci, Kofu, Yamanashi, Japan.
   [Hirasawa, T.; Obata, C.] Japan Sci & Technol Agcy JST, CREST, Kawaguchi, Saitama, Japan.
C3 University of Yamanashi; University of Yamanashi; University of
   Yamanashi; Japan Science & Technology Agency (JST)
RP Hirasawa, T (corresponding author), Univ Yamanashi, Dept Epigenet Med, Chuo Ku, 1110 Shimokato, Yamanashi 4093898, Japan.
EM takae@yamanashi.ac.jp
RI Moriishi, Kohji/I-4173-2019; Kasai, Hirotake/L-9668-2017
OI Moriishi, Kohji/0000-0002-9542-5188
FU JSPS KAKENHI, Japan [23591491, 25670473]; Japan Science and Technology
   Agency (JST); Grants-in-Aid for Scientific Research [23591491, 25670473]
   Funding Source: KAKEN
FX This study was supported by grants for Scientific Research (C) (23591491
   to T Hirasawa) and Exploratory Research (25670473 to T Kubota) from JSPS
   KAKENHI, Japan, and by a grant for Core Research for Evolutional Science
   and Technology (CREST) from the Japan Science and Technology Agency
   (JST) (to T Hirasawa).
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NR 44
TC 14
Z9 15
U1 0
U2 12
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 2040-1744
EI 2040-1752
J9 J DEV ORIG HLTH DIS
JI J. Dev. Orig. Health Dis.
PD APR
PY 2015
VL 6
IS 2
BP 105
EP 114
DI 10.1017/S2040174415000100
PG 10
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA CF7LR
UT WOS:000352738400006
PM 25708481
DA 2025-06-11
ER

PT J
AU Tavasoli, S
   Taheri, M
AF Tavasoli, Sanaz
   Taheri, Maryam
TI Vitamin D and calcium kidney stones: a review and a proposal
SO INTERNATIONAL UROLOGY AND NEPHROLOGY
LA English
DT Review
DE Urolithiasis; Calcium stones; Vitamin D deficiency; Oxidative stress;
   Secondary hyperparathyroidism; Inflammation
ID MONOCYTE CHEMOATTRACTANT PROTEIN-1; RENIN-ANGIOTENSIN SYSTEM;
   SELF-REPORTED HISTORY; OXIDATIVE STRESS; OXALATE CRYSTAL; D DEFICIENCY;
   METABOLIC SYNDROME; NATIONAL-HEALTH; NADPH OXIDASE; ESSENTIAL
   HYPERTENSIVES
AB Urolithiasis is a common, highly recurrent disease with increasing prevalence worldwide. The association between vitamin D and calcium stones has often been investigated on the basis of the role of vitamin D in calcium homeostasis. Currently, there is no consensus on the management of vitamin D deficiency in patients with renal calculi, because of controversies about the relationship between vitamin D and calcium stones. However, the vitamin D deficiency is shown to be highly prevalent among kidney stone formers, and some studies found a higher prevalence in stone formers compared with non-stone formers. This article attempts to review the relationship between calcium stones and vitamin D, and propose a mechanism for the association between vitamin D deficiency and calcium-based calculi according to the substantial role of inflammation and oxidative stress in calcium stone formation and also the pro-inflammatory effect of vitamin D deficiency.
C1 [Tavasoli, Sanaz; Taheri, Maryam] Shahid Beheshti Univ Med Sci, Urol & Nephrol Res Ctr, 103 Shahid Jafari St,Pasdaran Ave, Tehran, Iran.
C3 Shahid Beheshti University Medical Sciences
RP Tavasoli, S (corresponding author), Shahid Beheshti Univ Med Sci, Urol & Nephrol Res Ctr, 103 Shahid Jafari St,Pasdaran Ave, Tehran, Iran.
EM s.tavasoli@sbmu.ac.ir
RI Tavasoli, Sanaz/M-9512-2019; Taheri, Maryam/AAH-8081-2019
OI Tavasoli, Sanaz/0000-0001-7561-3918; Taheri, Maryam/0000-0002-0647-2944
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NR 103
TC 22
Z9 24
U1 0
U2 18
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0301-1623
EI 1573-2584
J9 INT UROL NEPHROL
JI Int. Urol. Nephrol.
PD JAN
PY 2019
VL 51
IS 1
BP 101
EP 111
DI 10.1007/s11255-018-1965-z
PG 11
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA HH0JL
UT WOS:000455402200013
PM 30136085
DA 2025-06-11
ER

PT J
AU Jiménez, AR
   Torres, RRH
   Medrano, AW
   Romero, RU
   Barahona, I
   Molina, RV
AF Ramos Jimenez, Arnulfo
   Hernandez Torres, Rosa R.
   Wall Medrano, Abraham
   Urguidez Romero, Rene
   Barahona, Igor
   Villalobos Molina, Rafael
TI Body shape as body image determinant in university students
SO NUTRICION HOSPITALARIA
LA English
DT Article
DE Abdominal fat; Body constitution; Mental health
ID DYSMORPHIC DISORDER; YOUNG-ADULTS; METABOLIC SYNDROME; OBESE
   ADOLESCENTS; EUROPEAN-UNION; WEIGHT STATUS; SELF-ESTEEM; MASS INDEX;
   DISSATISFACTION; AGE
AB Introduction and objectives: Body shape (BSP) and body image (BI) are part of the external physical structure, then modifications in body shape necessarily affect body image; however, both combined have not been studied. The purpose of the study was to evaluate the statistical relationship between BSP and BI in university students.
   Method: Two hundred and ninety-six participants (17-35 years) were included in this study. Different anthropometric measurements were used to define their somatotype (BSP), body mass index (BMI), waist to hip ratio (WHR) and waist circumference (WC). In addition, a questionnaire on body image perception was applied (McElhone et al.), regarding "how do I look?", "how do I think others see me?", "how do others see me?", and "how do I want to look like?"
   Results: On average, men perceived themselves in normal weight; in contrast, women perceived themselves as overweight. Men were meso-endomorphic, while women were endo-mesomorphic as an average.
   Conclusion: Body shape measured as somatotype as well as WC and WHR were excellent determinants of body image. Participants who presented a higher endomorphy, WC and WHR and a lower ectomorphy had a higher appreciation of being overweight or obese and wish to become thinner.
C1 [Ramos Jimenez, Arnulfo; Wall Medrano, Abraham; Urguidez Romero, Rene] Univ Autonoma Ciudad Juarez, Inst Ciencias Biomed, Dept Hlth Sci, Ciudad Juarez, Mexico.
   [Hernandez Torres, Rosa R.] Univ Autonoma Chihuahua, Fac Ciencias Cultura Fis, Chihuahua, Mexico.
   [Barahona, Igor] Univ Nacl Autonoma Mexico, Unidad Cuernavaca, Inst Matemat, Cuernavaca, Morelos, Mexico.
   [Villalobos Molina, Rafael] Univ Nacl Autonoma Mexico, Fac Estudios Super Iztacala, Unit Biomed, Tlalnepantla, Mexico.
C3 Universidad Autonoma de Ciudad Juarez; Universidad Autonoma de
   Chihuahua; Universidad Nacional Autonoma de Mexico; Universidad Nacional
   Autonoma de Mexico
RP Jiménez, AR (corresponding author), Univ Autonoma Ciudad Juarez, Inst Ciencias Biomed, Lab Fisiol Ejercicio, Edificio Z, Ciudad Juarez 32310, Chihuahua, Mexico.
EM aramos@uacj.mx
RI Wall-Medrano, Abraham/AAX-1333-2020; Ramos-Jimenez, Arnulfo/G-6228-2017;
   Barahona, Igor/L-5709-2019; URQUIDEZ ROMERO, RENE/C-3422-2016;
   Ramos-Jimenez, Arnulfo/B-4684-2014
OI URQUIDEZ ROMERO, RENE/0000-0003-3827-6056; Ramos-Jimenez,
   Arnulfo/0000-0002-4347-6725
FU PRODEP, SEP, Mexico
FX The present study received founding from PRODEP, SEP, Mexico. The study
   sponsors were not involved in the research design, implementation or
   publication.
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NR 35
TC 1
Z9 1
U1 0
U2 12
PU ARAN EDICIONES, S L
PI MADRID
PA C/ CASTELLO, 128, 1O, MADRID, 28006, SPAIN
SN 0212-1611
EI 1699-5198
J9 NUTR HOSP
JI Nutr. Hosp.
PD SEP-OCT
PY 2017
VL 34
IS 5
BP 116
EP 122
DI 10.20960/nh.744
PG 7
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA FM7QV
UT WOS:000415276500014
OA gold, Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Sampson, NR
   Tetteh, MM
   Schulz, AJ
   Ramirez, E
   Wilkins, D
   de Majo, R
   Mentz, G
   Johnson-Lawrence, V
AF Sampson, Natalie R.
   Tetteh, Myra M.
   Schulz, Amy J.
   Ramirez, Erminia
   Wilkins, Donele
   de Majo, Ricardo
   Mentz, Graciela
   Johnson-Lawrence, Vicki
TI Multidirectional Translation of Environmental Health Science in
   Community Settings: The Case of Oxidative Stress Pathways
SO PROGRESS IN COMMUNITY HEALTH PARTNERSHIPS-RESEARCH EDUCATION AND ACTION
LA English
DT Article
DE Multidirectionality; environmental health promotion; oxidative stress;
   translational research; environmental health; tools
ID AIR-POLLUTION EXPOSURE; PARTICULATE MATTER; INFLAMMATION; PARTNERSHIP;
   DYSFUNCTION; CAPACITY; RISK
AB Background: Translation of environmental health science in vulnerable communities is particularly important to promote public health and reduce health inequities.
   Methods: We describe a structured, multidirectional process used to develop a suite of health promotion tools (e.g., fact sheets, video, maps) documenting patterning of local air pollution sources and availability of antioxidant-rich foods in Detroit, Michigan as factors that jointly affect oxidative stress (OS). OS underlies many pathological processes associated with air pollution, including asthma, metabolic syndrome, cancer, diabetes, and obesity. This translational effort involved a 2-year dialogue among representatives from community-based and environmental organizations, health service providers, and academic researchers.
   Results: This dialogue led to development of tools, as well as new opportunities to inform related policies and research.
   Conclusions: Through this example, we highlight how collaborative partnerships can enhance multidirectional dialogue to inform translation of environmental health science by promoting consideration of multilevel risk factors, local priorities and context, and diverse audiences.
C1 [Sampson, Natalie R.] Univ Michigan Dearborn, Coll Educ Hlth & Human Serv, Dept Hlth & Human Serv, Dearborn, MI 48128 USA.
   [Tetteh, Myra M.; Schulz, Amy J.; de Majo, Ricardo; Mentz, Graciela] Univ Michigan, Sch Publ Hlth, Dept Hlth Behav Hlth Educ, Ann Arbor, MI 48109 USA.
   [Ramirez, Erminia] Community Hlth & Social Serv Ctr, Detroit, MI USA.
   [Wilkins, Donele] Green Door Initiat, Detroit, MI USA.
   [Johnson-Lawrence, Vicki] Univ Michigan Flint, Sch Publ Hlth, Dept Publ Hlth & Hlth Sci, Flint, MI USA.
C3 University of Michigan System; University of Michigan Dearborn;
   University of Michigan System; University of Michigan; University of
   Michigan System; University of Michigan Flint
RP Sampson, NR (corresponding author), Univ Michigan Dearborn, Coll Educ Hlth & Human Serv, Dept Hlth & Human Serv, Dearborn, MI 48128 USA.
RI Schulz, Amy/ADZ-4839-2022; Johnson-Lawrence, Vicki/G-8539-2014
OI Johnson-Lawrence, Vicki/0000-0002-8582-3916
FU National institute of Environmental Health Science [P30ES017885];
   National Institute of Environmental Health Sciences [P30ES017885]
   Funding Source: NIH RePORTER
FX This work was funded by the National institute of Environmental Health
   Science (P30ES017885). The authors thank MLEEaD scientists, including
   Rita Loch-Caruso and Toby Lewis, for their presentation of OS research
   to the SAB and review of the scientific content of the OS fact sheets
   and videos. We also thank members of the SAB for their contributions,
   particularly Donele Wilkins for her role in producing the video and
   Sheryl Weir for her contributions to the video discussion guide. We also
   recognize many community partners and students for their instrumental
   role in developing the fact sheets and video, including Josillia
   Johnson, Rebecca Mandell, Kwamena Mensah, Nicola Milgrom, Ezinne Ndukwe,
   Todd Scott, Malik Yakini, the D-Town Farms Community Garden, and members
   of the Green Door Initiative Green Jobs Training Core.
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NR 56
TC 5
Z9 5
U1 0
U2 4
PU JOHNS HOPKINS UNIV PRESS
PI BALTIMORE
PA JOURNALS PUBLISHING DIVISION, 2715 NORTH CHARLES ST, BALTIMORE, MD
   21218-4363 USA
SN 1557-0541
EI 1557-055X
J9 PROG COMM HLTH PARTN
JI Prog. Community Health Partnersh.
PD SUM
PY 2016
VL 10
IS 2
BP 275
EP 284
PG 10
WC Public, Environmental & Occupational Health
WE Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA DP2ME
UT WOS:000378322000014
PM 27346774
DA 2025-06-11
ER

PT J
AU Almadi, T
   Cathers, I
   Mansour, AMH
   Chow, CM
AF Almadi, Tawfiq
   Cathers, Ian
   Mansour, Ayman M. Hamdan
   Chow, Chin Moi
TI The association between work stress and inflammatory biomarkers in
   Jordanian male workers
SO PSYCHOPHYSIOLOGY
LA English
DT Article
DE Biochemical; Psychopathological
ID C-REACTIVE PROTEIN; EFFORT-REWARD IMBALANCE; ACUTE-PHASE PROTEINS;
   CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; PHYSICAL-ACTIVITY; WAIST
   CIRCUMFERENCE; CRP LEVELS; RISK; INTERLEUKIN-6
AB The study aimed to establish the association of work stress, expressed as effort-reward imbalance (ERI), and C-reactive protein (CRP) in 152 healthy Jordanian male employees. Self-report work stress, anthropometric data, and blood for CRP analysis were collected. A significant correlation between ERI and CRP (r=0.29, p<.01), and between waist circumference with CRP (r=0.44, p<.01) was found. Central obesity explained most of the variance in CRP after controlling for various covariates, and ERI was not a significant predictor of CRP (Delta R2=0.02; beta=0.15, p=.052). However, when only the centrally obese group was considered, ERI accounted for 5.0% of the variability in the CRP (beta=0.24, p<.05). Results of this study confirm previous findings that obesity is significantly associated with CRP, and support the notion that higher ERI amongst obese workers is one small but significant predictor of increased levels of CRP.
C1 [Almadi, Tawfiq; Cathers, Ian; Chow, Chin Moi] Univ Sydney, Fac Hlth Sci, Discipline Exercise & Sport Sci, Lidcombe, NSW 1825, Australia.
   [Mansour, Ayman M. Hamdan] Univ Jordan, Fac Nursing, Dept Community Hlth, Amman, Jordan.
C3 University of Sydney; University of Jordan
RP Almadi, T (corresponding author), Univ Sydney, Fac Hlth Sci, Discipline Exercise & Sport Sci, POB 170, Lidcombe, NSW 1825, Australia.
EM talm3809@uni.sydney.edu.au
RI Chow, Chin Moi/B-2971-2013; hamdan mansour, ayman/C-1257-2015
OI Chow, Chin Moi/0000-0001-9916-9882; hamdan mansour,
   ayman/0000-0002-9855-951X; Mansour, Ahmad/0000-0002-5849-4838
CR [Anonymous], INT DIAB FED CONS WO
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NR 41
TC 10
Z9 11
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0048-5772
EI 1469-8986
J9 PSYCHOPHYSIOLOGY
JI Psychophysiology
PD FEB
PY 2012
VL 49
IS 2
BP 172
EP 177
DI 10.1111/j.1469-8986.2011.01296.x
PG 6
WC Psychology, Biological; Neurosciences; Physiology; Psychology;
   Psychology, Experimental
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Neurosciences & Neurology; Physiology
GA 879NC
UT WOS:000299335600004
PM 22091987
DA 2025-06-11
ER

PT J
AU Madhusudhan, T
   Wang, HJ
   Dong, W
   Ghosh, S
   Bock, F
   Thangapandi, VR
   Ranjan, S
   Wolter, J
   Kohli, S
   Shahzad, K
   Heidel, F
   Krueger, M
   Schwenger, V
   Moeller, MJ
   Kalinski, T
   Reiser, J
   Chavakis, T
   Isermann, B
AF Madhusudhan, Thati
   Wang, Hongjie
   Dong, Wei
   Ghosh, Sanchita
   Bock, Fabian
   Thangapandi, Veera Raghavan
   Ranjan, Satish
   Wolter, Juliane
   Kohli, Shrey
   Shahzad, Khurrum
   Heidel, Florian
   Krueger, Martin
   Schwenger, Vedat
   Moeller, Marcus J.
   Kalinski, Thomas
   Reiser, Jochen
   Chavakis, Triantafyllos
   Isermann, Berend
TI Defective podocyte insulin signalling through p85-XBP1 promotes
   ATF6-dependent maladaptive ER-stress response in diabetic nephropathy
SO NATURE COMMUNICATIONS
LA English
DT Article
ID ENDOPLASMIC-RETICULUM-STRESS; CHRONIC KIDNEY-DISEASE; BOX-BINDING
   PROTEIN-1; GLUCOSE-HOMEOSTASIS; REGULATORY SUBUNITS; GLOMERULAR
   PODOCYTE; METABOLIC SYNDROME; INCREASES; RISK; ACTIVATION
AB Endoplasmic reticulum (ER) stress is associated with diabetic nephropathy (DN), but its pathophysiological relevance and the mechanisms that compromise adaptive ER signalling in podocytes remain unknown. Here we show that nuclear translocation of the transcription factor spliced X-box binding protein-1 (sXBP1) is selectively impaired in DN, inducing activating transcription factor-6 (ATF6) and C/EBP homology protein (CHOP). Podocyte-specific genetic ablation of XBP1 or inducible expression of ATF6 in mice aggravates DN. sXBP1 lies downstream of insulin signalling and attenuating podocyte insulin signalling by genetic ablation of the insulin receptor or the regulatory subunits phosphatidylinositol 3-kinase (PI3K) p85 alpha or p85 beta impairs sXBP1 nuclear translocation and exacerbates DN. Corroborating our findings from murine DN, the interaction of sXBP1 with p85 alpha and p85 beta is markedly impaired in the glomerular compartment of human DN. Thus, signalling via the insulin receptor, p85, and XBP1 maintains podocyte homeostasis, while disruption of this pathway impairs podocyte function in DN.
C1 [Madhusudhan, Thati; Wang, Hongjie; Dong, Wei; Ghosh, Sanchita; Bock, Fabian; Ranjan, Satish; Wolter, Juliane; Kohli, Shrey; Shahzad, Khurrum; Isermann, Berend] Otto von Guericke Univ, Fac Med, Inst Clin Chem & Pathobiochem, D-39120 Magdeburg, Germany.
   [Wang, Hongjie] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Cardiol, Wuhan 430030, Peoples R China.
   [Thangapandi, Veera Raghavan; Heidel, Florian] Otto von Guericke Univ, Fac Med, Dept Internal Med Hematol & Oncol, D-39120 Magdeburg, Germany.
   [Shahzad, Khurrum] Univ Hlth Sci, Khayaban e Jamia Punjab, Lahore 54600, Pakistan.
   [Krueger, Martin] Univ Leipzig, Inst Anat, D-04103 Leipzig, Germany.
   [Schwenger, Vedat] Heidelberg Univ, Internal Med & Div Nephrol 1, D-69120 Heidelberg, Germany.
   [Moeller, Marcus J.] RWTH Aachen Univ Technol, Univ Hosp, Div Nephrol & Immunol, D-52074 Aachen, Germany.
   [Kalinski, Thomas] Otto von Guericke Univ, Fac Med, Inst Pathol, D-39120 Magdeburg, Germany.
   [Reiser, Jochen] Rush Univ, Div Med, Chicago, IL 60612 USA.
   [Chavakis, Triantafyllos] Tech Univ Dresden, Dept Clin Pathobiochem, D-01307 Dresden, Germany.
   [Chavakis, Triantafyllos] Tech Univ Dresden, Inst Clin Chem, D-01307 Dresden, Germany.
   [Chavakis, Triantafyllos] Tech Univ Dresden, Lab Med, D-01307 Dresden, Germany.
C3 Otto von Guericke University; Huazhong University of Science &
   Technology; Otto von Guericke University; University of Health Science -
   Pakistan; Leipzig University; Ruprecht Karls University Heidelberg; RWTH
   Aachen University; RWTH Aachen University Hospital; Otto von Guericke
   University; Rush University; Technische Universitat Dresden; Technische
   Universitat Dresden; Technische Universitat Dresden
RP Madhusudhan, T (corresponding author), Otto von Guericke Univ, Fac Med, Inst Clin Chem & Pathobiochem, D-39120 Magdeburg, Germany.
EM madhusudhan.thati@med.ovgu.de; berend.isermann@med.ovgu.de
RI Chavakis, Triantafyllos/ABE-8845-2020; Bock, Fabian/K-3366-2019;
   Moeller, Marcus/L-1836-2015; Heidel, Florian/KIY-7104-2024
OI Heidel, Florian/0000-0003-2438-1955; Reiser, Jochen/0000-0002-0460-662X;
   Ranjan, Dr. Satish/0000-0003-0200-5385
FU 'Deutsche Forschungsgemeinschaft' [IS 67/2-4, IS-67/5-2, SFB 854, TH
   1789/1-1, CH279/5-1]; 'Stiftung Pathobiochemie und Molekulare
   Diagnostik; European Research Council (ENDHOMRET); EASD; Bristol
   Myers-Squibb; AstraZeneca; National Institute of Diabetes and Digestive
   and Kidney Diseases [P30DK081943] Funding Source: NIH RePORTER
FX This work was supported by grants of the 'Deutsche
   Forschungsgemeinschaft' (IS 67/2-4, IS-67/5-2, SFB 854 to BI, TH
   1789/1-1 to TM, and CH279/5-1 to TC), of the 'Stiftung Pathobiochemie
   und Molekulare Diagnostik to B.I. and T.M., of the European Research
   Council (ENDHOMRET) to T.C., and from the EASD to B.I. Support for this
   study was provided by Bristol Myers-Squibb and AstraZeneca. We thank
   Laurie Glimcher (Weill Cornell Medical College, New York) for providing
   XBP1<SUP>flox</SUP> mice; we thank Hans-Joachim Anders, University of
   Munich, for providing immortalized mouse glomerular endothelial cells,
   Ingo Bechmann, University of Leipzig for supporting with electron
   microscopy studies. We thank Kathrin Deneser, Julia Judin, Juliane
   Friedrich, Rene Rudat and Rumiya Makarova for excellent technical
   support.
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NR 57
TC 148
Z9 158
U1 0
U2 29
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 2041-1723
J9 NAT COMMUN
JI Nat. Commun.
PD MAR
PY 2015
VL 6
AR 6496
DI 10.1038/ncomms7496
PG 15
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA CF6WN
UT WOS:000352697500005
PM 25754093
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Calcaterra, V
   Cena, H
   Pelizzo, G
   Porri, D
   Regalbuto, C
   Vinci, F
   Destro, F
   Vestri, E
   Verduci, E
   Bosetti, A
   Zuccotti, G
   Stanford, FC
AF Calcaterra, Valeria
   Cena, Hellas
   Pelizzo, Gloria
   Porri, Debora
   Regalbuto, Corrado
   Vinci, Federica
   Destro, Francesca
   Vestri, Elettra
   Verduci, Elvira
   Bosetti, Alessandra
   Zuccotti, Gianvincenzo
   Stanford, Fatima Cody
TI Bariatric Surgery in Adolescents: To Do or Not to Do?
SO CHILDREN-BASEL
LA English
DT Review
DE pediatric obesity; bariatric surgery; adolescents; nutritional status;
   weight loss; laparoscopic sleeve gastrectomy; multi-disciplinarity;
   complications
ID LAPAROSCOPIC SLEEVE GASTRECTOMY; Y GASTRIC BYPASS; SEVERELY OBESE
   ADOLESCENTS; 3RD NATIONAL-HEALTH; FATTY LIVER-DISEASE; BODY-MASS INDEX;
   METABOLIC SYNDROME; WEIGHT-LOSS; GUT HORMONES; YOUNG-ADULTS
AB Pediatric obesity is a multifaceted disease that can impact physical and mental health. It is a complex condition that interweaves biological, developmental, environmental, behavioral, and genetic factors. In most cases lifestyle and behavioral modification as well as medical treatment led to poor short-term weight reduction and long-term failure. Thus, bariatric surgery should be considered in adolescents with moderate to severe obesity who have previously participated in lifestyle interventions with unsuccessful outcomes. In particular, laparoscopic sleeve gastrectomy is considered the most commonly performed bariatric surgery worldwide. The procedure is safe and feasible. The efficacy of this weight loss surgical procedure has been demonstrated in pediatric age. Nevertheless, there are barriers at the patient, provider, and health system levels, to be removed. First and foremost, more efforts must be made to prevent decline in nutritional status that is frequent after bariatric surgery, and to avoid inadequate weight loss and weight regain, ensuring successful long-term treatment and allowing healthy growth. In this narrative review, we considered the rationale behind surgical treatment options, outcomes, and clinical indications in adolescents with severe obesity, focusing on LSG, nutritional management, and resolution of metabolic comorbidities.
C1 [Calcaterra, Valeria] Univ Pavia, Dept Internal Med, Pediat & Adolescent Unit, I-27100 Pavia, Italy.
   [Calcaterra, Valeria; Vestri, Elettra; Verduci, Elvira; Bosetti, Alessandra] V Buzzi Childrens Hosp, Pediat Dept, I-20154 Milan, Italy.
   [Cena, Hellas; Porri, Debora] ICS Maugeri IRCCS, Unit Internal Med & Endocrinol, Clin Nutr & Dietet Serv, I-27100 Pavia, Italy.
   [Cena, Hellas; Porri, Debora] Univ Pavia, Lab Dietet & Clin Nutr, Dept Publ Hlth Expt & Forens Med, I-27100 Pavia, Italy.
   [Pelizzo, Gloria; Destro, Francesca] Pediat Surg Dept, V Buzzi Childrens Hosp, I-20154 Milan, Italy.
   [Regalbuto, Corrado; Vinci, Federica] Fond IRCCS Policlin S Matteo, Pediat Unit, I-27100 Pavia, Italy.
   [Calcaterra, Valeria; Regalbuto, Corrado; Vinci, Federica] Univ Pavia, I-27100 Pavia, Italy.
   [Verduci, Elvira] Univ Milan, Dept Hlth Sci, I-20146 Milan, Italy.
   [Zuccotti, Gianvincenzo] Univ Milan, L Sacco Dept Biomed & Clin Sci, I-20146 Milan, Italy.
   [Stanford, Fatima Cody] Massachusetts Gen Hosp, Boston, MA 02114 USA.
   [Stanford, Fatima Cody] Harvard Med Sch, Boston, MA 02115 USA.
C3 University of Pavia; Istituti Clinici Scientifici Maugeri IRCCS;
   University of Pavia; IRCCS Fondazione San Matteo; University of Pavia;
   University of Milan; University of Milan; Harvard University; Harvard
   University Medical Affiliates; Massachusetts General Hospital; Harvard
   University; Harvard Medical School
RP Pelizzo, G (corresponding author), Pediat Surg Dept, V Buzzi Childrens Hosp, I-20154 Milan, Italy.
EM valeria.calcaterra@unipv.it; hellas.cena@unipv.it;
   gloriapelizzo@gmail.com; Debora.porri01@universitadipavia.it;
   corrado.regalbuto01@universitadipavia.it; fede90vinci@gmail.com;
   francesca.destro@asst-fbf-sacco.it; elettra.vestri@asst-fbf-sacco.it;
   elvira.verduci@unimi.it; alessandra.bosetti@asst-fbf-sacco.it;
   GianVincenzo.Zuccotti@unimi.it; fstanford@mgh.harvard.edu
RI Destro, Francesca/E-7961-2017; Verduci, Elvira/D-7338-2014; porri,
   debora/LRU-6886-2024; Calcaterra, Valeria/AAB-7563-2022; Zuccotti,
   Gianvincenzo/H-8572-2017; Stanford, Fatima/H-3953-2019; Cena,
   Hellas/AAB-9995-2019
OI Destro, Francesca/0000-0002-0206-2892; Porri,
   Debora/0000-0002-3327-5057; Zuccotti, Gianvincenzo/0000-0002-2795-9874;
   Verduci, Elvira/0000-0003-2111-3111; CALCATERRA,
   VALERIA/0000-0002-2137-5974; Stanford, Fatima/0000-0003-4616-533X; Cena,
   Hellas/0000-0002-5752-6199
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NR 163
TC 18
Z9 19
U1 0
U2 6
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2227-9067
J9 CHILDREN-BASEL
JI Children-Basel
PD JUN
PY 2021
VL 8
IS 6
AR 453
DI 10.3390/children8060453
PG 20
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Pediatrics
GA SX8TD
UT WOS:000665469200001
PM 34072065
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Gomes, E
   Bastos, T
   Probst, M
   Ribeiro, JC
   Silva, G
   Corredeira, R
AF Gomes, Eluana
   Bastos, Tania
   Probst, Michel
   Ribeiro, Jose C.
   Silva, Gustavo
   Corredeira, Rui
TI Quality of life and physical activity levels in outpatients with
   schizophrenia
SO REVISTA BRASILEIRA DE PSIQUIATRIA
LA English
DT Article
DE Quality of life; physical activity; outpatients; schizophrenia
ID METABOLIC SYNDROME; PEOPLE; SMOKING; IMPACT
AB Objectives: To assess quality of life (QoL) and physical activity (PA) levels of outpatients with schizophrenia and healthy controls matched for age, gender, body mass index (BMI), hip circumference, waist circumference, and waist-to-hip ratio. Additionally, the present study investigated associations between PA levels, QoL, and anthropometric and behavioral measures among outpatients with schizophrenia.
   Methods: Thirty-two outpatients with schizophrenia and 32 individuals without mental illness were included in the study. QoL and PA levels were assessed by the World Health Organization Quality of Life Instrument - Abbreviated version (WHOQOL-Bref) and by GT3X triaxial accelerometers, respectively.
   Results: Outpatients with schizophrenia had poorer QoL and lower vigorous PA levels compared with healthy controls (p < 0.05). The group with schizophrenia showed a significant association between higher weight and lower scores in the mental health domain of the WHOQOL-Bref. A higher BMI was also significantly associated with lower scores in the physical health domain of the WHOQOL-Bref. Schizophrenic patients with smoking behaviors were associated with fewer steps per day and with less moderate to vigorous PA.
   Conclusions: This study seeks to shed some light upon the lifestyle of patients with schizophrenia. New psychosocial approaches should focus on PA, weight, and smoking management, thereby helping these patients to improve their QoL.
C1 [Gomes, Eluana; Ribeiro, Jose C.; Silva, Gustavo; Corredeira, Rui] Univ Porto, Fac Desporto, Ctr Invest Atividade Fis Saude & Lazer CIAFEL, P-4200450 Oporto, Portugal.
   [Bastos, Tania] Univ Porto, Fac Desporto, CIFI2D, P-4200450 Oporto, Portugal.
   [Bastos, Tania] Inst Univ Maia ISMAI, Ctr Invest Desporto Saude & Desenvolvimento Human, Maia, Portugal.
   [Probst, Michel] Katholieke Univ Leuven, Fac Kinesiol & Rehabil Sci, Res Grp Adapted Phys Act & Psychomotor Rehabil, Leuven, Belgium.
C3 Universidade do Porto; Universidade do Porto; Instituto Universitario da
   Maia (ISMAI); KU Leuven
RP Gomes, E (corresponding author), Univ Porto, Fac Desporto, Rua Dr Placido Costa 91, P-4200450 Oporto, Portugal.
EM aeluana@yahoo.com.br
RI Probst, Michel/ABE-6137-2020; Silva, Gustavo/L-7529-2013; Corredeira,
   Rui/A-7265-2014; Ribeiro, Jose/L-7487-2013
OI Silva, Gustavo/0000-0003-3930-7037; Gomes, Eluana/0000-0002-2156-1451;
   Corredeira, Rui/0000-0002-2125-0805; Ribeiro, Jose/0000-0001-6628-4606
FU Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES); 
   [UID/DTP/00617/2013]; Fundação para a Ciência e a Tecnologia
   [UID/DTP/00617/2013] Funding Source: FCT
FX The PhD project was funded by Coordenacao de Aperfeicoamento de Pessoal
   de Nivel Superior (CAPES). We would like to thank Associacao Nova Aurora
   de Reabilitacao e Reintegracao Psicossocial (ANARP), the Department of
   Psychiatry at Hospital Sao Joao, and the Department of Psychiatry at
   Hospital Santo Antonio. Centro de Investigacao em Atividade Fisica,
   Saude e Lazer (CIAFEL) is supported by UID/DTP/00617/2013.
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NR 17
TC 18
Z9 24
U1 1
U2 13
PU ASSOC BRASILEIRA PSIQUIATRIA
PI SAO PAULO
PA SUBSCRIPTION DEPARTMENT, RUA PEDRO DE TOLEDO, 967 - CASA 01, SAO PAULO,
   SP 04039-032  A, BRAZIL
SN 1516-4446
EI 1809-452X
J9 REV BRAS PSIQUIATR
JI Rev. Bras. Psiquiatr.
PD APR-JUN
PY 2016
VL 38
IS 2
BP 157
EP 160
DI 10.1590/1516-4446-2015-1709
PG 4
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA DP1FB
UT WOS:000378234800011
PM 26814836
OA Green Accepted, Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Siddiqui, A
   Madhu, SV
   Sharma, SB
   Desai, NG
AF Siddiqui, Azaz
   Madhu, S. V.
   Sharma, S. B.
   Desai, N. G.
TI Endocrine stress responses and risk of type 2 diabetes mellitus
SO STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS
LA English
DT Article
DE Activation; alpha amylase; cortisol; diabetes; salivary; stress-pathways
ID SALIVARY ALPHA-AMYLASE; PITUITARY-ADRENAL AXIS;
   SYMPATHETIC-NERVOUS-SYSTEM; AGED SWEDISH MEN; INSULIN-RESISTANCE;
   METABOLIC SYNDROME; PSYCHOLOGICAL DISTRESS; PERCEIVED STRESS; WHITEHALL
   II; WORK STRESS
AB This study was carried to ascertain whether stress responses are associated with abnormalities in glucose tolerance, insulin sensitivity and pancreatic beta cell function and risk of type 2 Diabetes Mellitus. Salivary cortisol, a marker of hypothalamic-pituitary-adrenal (HPA) axis and salivary a-amylase, a marker of sympathetic nervous system (SNS) were compared in 125 subjects of newly detected diabetes mellitus (NDDM) and normal glucose tolerance (NGT) subjects who were diagnosed on the basis of oral glucose tolerance test (OGTT). Assessment of stress in them was done through stress scales - presumptive stressful life events scale (PSLES), perceived stress scale (PSS) and sense of coherence (SOC) and correlated with these and other stress response markers. Significantly higher 10 pm salivary cortisol and post dexamethasone salivary cortisol were found in NDDM subjects as compared to NGT. 10 pm salivary cortisol correlated significantly with fasting plasma glucose (FPG), 2 h plasma glucose (2h PG) and glycated hemoglobin (HbA1c) while post dex salivary cortisol correlated with 2h PG, HbA1c and salivary a-amylase with 2h PG. Stepwise logistic regression analysis showed that body mass index (OR: 1.840), SOC (OR: 0.688) and 10 pm salivary cortisol (OR: 1.427) were the strongest predictors of NDDM. The results of the present study indicate that NDDM subjects display significantly higher chronic stress and stress responses when compared to subjects with NGT. Chronic stress and endocrine stress responses are significantly associated with glucose intolerance, insulin resistance and diabetes mellitus.
C1 [Siddiqui, Azaz] Cent Res Inst, Kasauli, Himachal Prades, India.
   [Siddiqui, Azaz; Madhu, S. V.] Univ Delhi, Univ Coll Med Sci, Dept Med, Ctr Diabet Endocrinol & Metab, Delhi 110007, India.
   [Sharma, S. B.] Univ Delhi, Univ Coll Med Sci, Dept Med Biochem, Delhi 110007, India.
   [Desai, N. G.] Inst Human Behav & Allied Sci, Dept Psychiat, Delhi, India.
C3 University of Delhi; University College of Medical Sciences; University
   of Delhi; University College of Medical Sciences
RP Madhu, SV (corresponding author), Univ Coll Med Sci, Dept Med, Delhi 110095, India.
EM drsvmadhu@gmail.com
RI Madhu, S/AAH-7431-2019
FU Indian Council of Medical Research, New Delhi, India
FX All authors declare no conflict of interest. This work was supported by
   a grant from Indian Council of Medical Research, New Delhi, India.
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NR 45
TC 48
Z9 52
U1 0
U2 22
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1025-3890
EI 1607-8888
J9 STRESS
JI Stress
PY 2015
VL 18
IS 5
BP 498
EP 506
DI 10.3109/10253890.2015.1067677
PG 9
WC Behavioral Sciences; Endocrinology & Metabolism; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Behavioral Sciences; Endocrinology & Metabolism; Neurosciences &
   Neurology
GA DD4JP
UT WOS:000369888600002
PM 26270888
DA 2025-06-11
ER

PT J
AU Hsu, JY
   Lin, HH
   Chyau, CC
   Wang, ZH
   Chen, JH
AF Hsu, Jen-Ying
   Lin, Hui-Hsuan
   Chyau, Charng-Cherng
   Wang, Zhi-Hong
   Chen, Jing-Hsien
TI Aqueous Extract of Pepino Leaves Ameliorates Palmitic Acid-Induced
   Hepatocellular Lipotoxicity via Inhibition of Endoplasmic Reticulum
   Stress and Apoptosis
SO ANTIOXIDANTS
LA English
DT Article
DE aqueous extract of pepino leaf; lipotoxicity; endoplamic reticulum
   stress; apoptosis; oxidative stress; non-alcoholic fatty liver disease
ID SATURATED FATTY-ACIDS; OXIDATIVE STRESS; MITOCHONDRIAL DYSFUNCTION;
   LIQUID-CHROMATOGRAPHY; LIVER-DISEASE; ACTIVATION; CELLS; HOMEOSTASIS;
   INCREASES; CLEAVAGE
AB Saturated fatty acid is one of the important nutrients, but contributes to lipotoxicity in the liver, causing hepatic steatosis. Aqueous pepino leaf extract (AEPL) in the previous study revealed alleviated liver lipid accumulation in metabolic syndrome mice. The study aimed to investigate the mechanism of AEPL on saturated long-chain fatty acid-induced lipotoxicity in HepG2 cells. Moreover, the phytochemical composition of AEPL was identified in the present study. HepG2 cells treated with palmitic acid (PA) were used for exploring the effect of AEPL on lipid accumulation, apoptosis, ER stress, and antioxidant response. The chemical composition of AEPL was analyzed by HPLC-ESI-MS/MS. AEPL treatment reduced PA-induced ROS production and lipid accumulation. Further molecular results revealed that AEPL restored cytochrome c in mitochondria and decreased caspase 3 activity to cease apoptosis. In addition, AEPL in PA-stressed HepG2 cells significantly reduced the ER stress and suppressed SREBP-1 activation for decreasing lipogenesis. For defending PA-induced oxidative stress, AEPL promoted Nrf2 expression and its target genes, SOD1 and GPX3, expressions. The present study suggested that AEPL protected from PA-induced lipotoxicity through reducing ER stress, increasing antioxidant ability, and inhibiting apoptosis. The efficacy of AEPL on lipotoxicity was probably concerned with kaempferol and isorhamnetin derived compounds.
C1 [Hsu, Jen-Ying; Chen, Jing-Hsien] Chung Shan Med Univ, Dept Nutr, Taichung 40201, Taiwan.
   [Lin, Hui-Hsuan] Chung Shan Med Univ, Dept Med Lab & Biotechnol, Taichung 40201, Taiwan.
   [Chyau, Charng-Cherng] Hungkuang Univ, Res Inst Biotechnol, Taichung 43302, Taiwan.
   [Wang, Zhi-Hong] Asia Univ, Dept Food Nutr & Hlth Biotechnol, Taichung 41354, Taiwan.
   [Chen, Jing-Hsien] Chung Shan Med Univ Hosp, Dept Med Res, Taichung 40201, Taiwan.
C3 Chung Shan Medical University; Chung Shan Medical University; Hungkuang
   University; Asia University Taiwan; Chung Shan Medical University; Chung
   Shan Medical University Hospital
RP Chen, JH (corresponding author), Chung Shan Med Univ, Dept Nutr, Taichung 40201, Taiwan.; Chen, JH (corresponding author), Chung Shan Med Univ Hosp, Dept Med Res, Taichung 40201, Taiwan.
EM jyhsu0530@gmail.com; linhh@csmu.edu.tw; ccchyau@sunrise.hk.edu.tw;
   wangzh@asia.edu.tw; cjh0828@csmu.edu.tw
RI Wang, Zhihong/H-5327-2013
OI /0000-0001-5232-8428; Lin, Hui-Hsuan/0000-0003-0021-5709; Chen,
   Jing-Hsien/0000-0001-5756-5959
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NR 53
TC 18
Z9 21
U1 0
U2 14
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD JUN
PY 2021
VL 10
IS 6
AR 903
DI 10.3390/antiox10060903
PG 18
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA SX6BR
UT WOS:000665288500001
PM 34204987
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Du, H
   Duan, SD
   Lei, R
   Liu, XY
AF Du, Hong
   Duan, Shidong
   Lei, Rui
   Liu, Xiaoyan
TI Astragalin Inhibits Insulin Resistance and Oxidative Stress in Palmitic
   Acid-Induced HEPG2 Cells
SO CURRENT TOPICS IN NUTRACEUTICAL RESEARCH
LA English
DT Article
DE Astragalin; HepG2; Insulin resistance; Metabolic diseases; Palmitic acid
ID ACTIVATION
AB Insulin resistance is an element of metabolic syndrome, manifested as a decrease in glucose uptake, which often leads to a variety of complications, including type 2 diabetes. Astragalin is a natural flavonoid, isolated from traditional medicinal plants, such as Cuscuta chinensis, that has been shown to exhibit a variety of pharmacological activities with anti-inflammatory, antioxidant, neuroprotective, cardioprotective, antiobesity, antiosteoporotic, anticancer, antiulcer, and antidiabetic properties. However, the mechanism of astragalin on insulin resistance has not yet been elucidated. To this end, we examined the effect of astragalin on palmitic acid-induced insulin resistance in HepG2 cells. The effects of the co-incubation of PA and astragalin on the cell viability, superoxide dismutase, fat content, and markers of oxidative stress in HepG2 cells were measured. The results show that astragalin restored the cell viability, reduced oxidative stress, and insulin resistance in palmitic acid treated HepG2 cells. The protective effect of astragalin on palmitic acid-induced lipotoxicity in HepG2 cells was through inhibition of NF-kappa B and JNK signaling pathways.
C1 [Du, Hong; Lei, Rui; Liu, Xiaoyan] Cent Hosp Enshi Tujia & Miao Autonomous Prefectur, Hlth Management Ctr, Enshi City, Hubei, Peoples R China.
   [Duan, Shidong] Cent Hosp Enshi Tujia & Miao Autonomous Prefectur, Enshi City 445000, Hubei, Peoples R China.
RP Lei, R (corresponding author), Cent Hosp Enshi Tujia & Miao Autonomous Prefectur, Hlth Management Ctr, 88 Jinlong Rd Sect, Enshi City, Hubei, Peoples R China.
EM rui_l8@163.com
CR Agyemang K, 2013, EVID-BASED COMPL ALT, V2013, DOI 10.1155/2013/654643
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NR 26
TC 1
Z9 2
U1 8
U2 46
PU NEW CENTURY HEALTH PUBLISHERS, LLC
PI COPPELL
PA PO BOX 175, COPPELL, TX 75019 USA
SN 1540-7535
EI 2641-452X
J9 CURR TOP NUTRACEUT R
JI Curr. Top. Nutraceutical Res.
PD NOV
PY 2022
VL 20
IS 4
BP 635
EP 640
AR 7
DI 10.37290/ctnr2641-452X.20:635-640
PG 6
WC Nutrition & Dietetics; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics; Pharmacology & Pharmacy
GA 6Q3VD
UT WOS:000891541500007
DA 2025-06-11
ER

PT J
AU Tsuneki, H
   Maeda, T
   Takata, S
   Sugiyama, M
   Otsuka, K
   Ishizuka, H
   Onogi, Y
   Tokai, E
   Koshida, C
   Kon, K
   Takasaki, I
   Hamashima, T
   Sasahara, M
   Rudich, A
   Koya, D
   Sakurai, T
   Yanagisawa, M
   Yamanaka, A
   Wada, T
   Sasaoka, T
AF Tsuneki, Hiroshi
   Maeda, Takahiro
   Takata, Shinjiro
   Sugiyama, Masanori
   Otsuka, Koyuki
   Ishizuka, Hinako
   Onogi, Yasuhiro
   Tokai, Emi
   Koshida, Chiaki
   Kon, Kanta
   Takasaki, Ichiro
   Hamashima, Takeru
   Sasahara, Masakiyo
   Rudich, Assaf
   Koya, Daisuke
   Sakurai, Takeshi
   Yanagisawa, Masashi
   Yamanaka, Akihiro
   Wada, Tsutomu
   Sasaoka, Toshiyasu
TI Hypothalamic orexin prevents non-alcoholic steatohepatitis and
   hepatocellular carcinoma in obesity
SO CELL REPORTS
LA English
DT Article
ID SPONTANEOUS PHYSICAL-ACTIVITY; HEPATIC INSULIN-RESISTANCE; FATTY
   LIVER-DISEASE; PERIPHERAL-TISSUES; METABOLIC SYNDROME; EXERCISE;
   GLUCOSE; MICE; STRESS; SYSTEM
AB Non-alcoholic steatohepatitis (NASH) occasionally occurs under obesity; however, factors modulating the natural history of fatty liver disease remain unknown. Since hypothalamic orexin that regulates physical ac-tivity and autonomic balance prevents obesity, we investigate its role in NASH development. Male orexin-deficient mice fed a high-fat diet (HFD) show severe obesity and progression of NASH with fibrosis in the liver. Hepatic fibrosis also develops in ovariectomized orexin-deficient females fed an HFD but not ovariectomized wild-type controls. Moreover, long-term HFD feeding causes hepatocellular carcinoma (HCC) in orexin-defi-cient mice. Intracerebroventricular injection of orexin A or pharmacogenetic activation of orexin neurons acutely activates hepatic mTOR-sXbp1 pathway to prevent endoplasmic reticulum (ER) stress, a NASH-causing factor. Daily supplementation of orexin A attenuates hepatic ER stress and inflammation in orexin-deficient mice fed an HFD, and autonomic ganglionic blocker suppresses the orexin actions. These results suggest that hypothalamic orexin is an essential factor for preventing NASH and associated HCC under obesity.
C1 [Tsuneki, Hiroshi; Maeda, Takahiro; Takata, Shinjiro; Sugiyama, Masanori; Otsuka, Koyuki; Ishizuka, Hinako; Onogi, Yasuhiro; Tokai, Emi; Koshida, Chiaki; Kon, Kanta; Wada, Tsutomu; Sasaoka, Toshiyasu] Univ Toyama, Dept Clin Pharmacol, 2630 Sugitani, Toyama 9300194, Japan.
   [Takasaki, Ichiro] Univ Toyama, Dept Pharmacol, Toyama, Japan.
   [Hamashima, Takeru; Sasahara, Masakiyo] Univ Toyama, Dept Pathol, Toyama, Japan.
   [Rudich, Assaf] Ben Gurion Univ Negev, Dept Clin Biochem & Pharmacol, Beer Sheva, Israel.
   [Koya, Daisuke] Kanazawa Med Univ, Dept Diabetol & Endocrinol, Kahoku, Ishikawa, Japan.
   [Sakurai, Takeshi; Yanagisawa, Masashi] Univ Tsukuba, Fac Med, WPI IIIS, Tsukuba, Japan.
   [Yamanaka, Akihiro] Nagoya Univ, Res Inst Environm Med, Dept Neurosci 2, Nagoya, Japan.
C3 University of Toyama; University of Toyama; University of Toyama;
   Ben-Gurion University of the Negev; Kanazawa Medical University;
   University of Tsukuba; Nagoya University
RP Tsuneki, H; Sasaoka, T (corresponding author), Univ Toyama, Dept Clin Pharmacol, 2630 Sugitani, Toyama 9300194, Japan.
EM htsuneki@pha.u-toyama.ac.jp; tsasaoka@pha.u-toyama.ac.jp
RI Wada, Tsutomu/AAY-4450-2020; Onogi, Yasuhiro/AAD-9305-2022; Kovacs,
   Werner/AAD-1107-2019; RUDICH, ASSAF/MSY-8816-2025; Sakurai,
   Takeshi/C-3335-2015
OI Wada, Tsutomu/0000-0001-5819-8556; Onogi, Yasuhiro/0000-0002-7950-8952;
   Takasaki, Ichiro/0000-0002-6083-1119
FU JSPS KAKENHI [JP15K09380, JP15K15599, JP19H05011, JP21K19704,
   JP22H03506]; JSPS and ISF under the Japan-Israel Research Cooperative
   Program; Toyama Pharmaceutical Valley Development Consortium; JST
   Moonshot RD [JPMJMS2021]; JST SPRING [JPMJSP2145]; JST-the establishment
   of university fellowships [JPMJFS2115]; Tamura Science and Technology
   Foundation; Grants-in-Aid for Scientific Research [23K24763, 22H03506,
   22H04918, 21H05036, 21K19287, 21K19704, 21H02713, 21K06574, 20K21773]
   Funding Source: KAKEN
FX This study was supported by JSPS KAKENHI grant numbers JP15K09380 (to
   H.T.), JP15K15599 (to T. Sasaoka), JP19H05011 (to T. Sasaoka),
   JP21K19704 (to H.T.), and JP22H03506 (to H.T.); JSPS and ISF under the
   Japan-Israel Research Cooperative Program (to T. Sasaoka); Toyama
   Pharmaceutical Valley Development Consortium (to T. Sasaoka); JST
   Moonshot R&D grant number JPMJMS2021 (to T. Sasaoka); JST SPRING grant
   number JPMJSP2145 (to T.M.); JST-the establishment of university
   fellowships toward the creation of science technology innovation grant
   number JPMJFS2115 (to M.S.); and Tamura Science and Technology
   Foundation (to T.Sasaoka). We thank Y. Nunome, T. Asaoka, Y. Matsuoka,
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   Inokuchi (University of Toyama, Japan) for their technical assistance.
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NR 69
TC 14
Z9 14
U1 2
U2 6
PU CELL PRESS
PI CAMBRIDGE
PA 50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA
SN 2211-1247
J9 CELL REP
JI Cell Reports
PD OCT 18
PY 2022
VL 41
IS 3
AR 111497
DI 10.1016/j.celrep.2022.111497
EA OCT 2022
PG 22
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA 6S5CV
UT WOS:000893005900007
PM 36261021
OA gold
DA 2025-06-11
ER

PT J
AU Mihanfar, A
   Nouri, M
   Roshangar, L
   Khadem-Ansari, MH
AF Mihanfar, Aynaz
   Nouri, Mohammad
   Roshangar, Leila
   Khadem-Ansari, Mohammad Hassan
TI Polyphenols: Natural compounds with promising potential in treating
   polycystic ovary syndrome
SO REPRODUCTIVE BIOLOGY
LA English
DT Review
DE PCOS; Polyphenols; Antioxidant; Stress oxidative
ID RAT MODEL; INSULIN-RESISTANCE; CINNAMON EXTRACT; DOUBLE-BLIND;
   INFLAMMATORY CYTOKINES; ANTIOXIDANT ACTIVITY; OXIDATIVE STRESS; LIPID
   PROFILE; UP-REGULATION; GALLIC ACID
AB Polyphenols are natural compounds used by plants as a defense system against various stresses. In recent years, the importance of these polyhydroxyphenols has extensively increased due to their potent cardioprotection, anti-carcinogenic, anti-oxidant, anti-apoptotic, and anti-inflammatory properties. Therefore, various studies have reported promising results from the studies investigating their efficacy as a therapeutic strategy in various disorders such as human malignancies, cardiovascular diseases, nervous system impairments, diabetes, metabolic syndrome, aging, and inflammation-associated disorders, as well as a polycystic ovarian syndrome (PCOS). Since oxidative stress, hormonal, metabolic, and endocrine disturbances have been shown to play a crucial role in the initiation/progression of PCOS, polyphenols are suggested to be an effective treatment for this disorder. Therefore, this study aimed to discuss the therapeutic potential of multiple polyphenols in PCOS. (C) 2021 Published by Elsevier B.V. on behalf of Society for Biology of Reproduction & the Institute of Animal Reproduction and Food Research of Polish Academy of Sciences in Olsztyn.
C1 [Mihanfar, Aynaz; Khadem-Ansari, Mohammad Hassan] Urmia Univ Med Sci, Fac Med, Dept Clin Biochem, Orumiyeh, Iran.
   [Nouri, Mohammad; Roshangar, Leila] Tabriz Univ Med Sci, Stem Cell Res Ctr, Tabriz, Iran.
   [Nouri, Mohammad] Tabriz Univ Med Sci, Fac Adv Med Sci, Dept Reprod Biol, Tabriz, Iran.
   [Nouri, Mohammad] Tabriz Univ Med Sci, Stem Cell & Regenerat Med Inst, Tabriz, Iran.
C3 Urmia University of Medical Sciences; Tabriz University of Medical
   Science; Tabriz University of Medical Science; Tabriz University of
   Medical Science
RP Khadem-Ansari, MH (corresponding author), Urmia Univ Med Sci, Fac Med, Dept Clin Biochem, Orumiyeh, Iran.
EM Ansari_mh@umsu.ac.ir
RI Roshangar, leila/H-3541-2018; Mihanfar, Aynaz/LUW-8667-2024; nouri,
   mohammad/HSB-4293-2023; ansari, Mohammad/N-8662-2017
OI Mihanfar, Aynaz/0000-0002-5801-0522
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NR 158
TC 27
Z9 28
U1 1
U2 25
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1642-431X
EI 2300-732X
J9 REPROD BIOL
JI Reprod. Biol.
PD JUN
PY 2021
VL 21
IS 2
AR 100500
DI 10.1016/j.repbio.2021.100500
EA APR 2021
PG 11
WC Reproductive Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Reproductive Biology
GA SN5RD
UT WOS:000658345700008
PM 33878526
DA 2025-06-11
ER

PT J
AU Dai, YX
   Chen, MH
   Chen, TJ
   Lin, MH
AF Dai, Ying-Xiu
   Chen, Mu-Hong
   Chen, Tzeng-Ji
   Lin, Ming-Hwai
TI Patterns of Psychiatric Outpatient Practice in Taiwan: A Nationwide
   Survey
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Article
DE national health programs; physician's practice patterns; psychiatry;
   Taiwan
ID COMORBIDITY SURVEY REPLICATION; OFFICE-BASED PHYSICIANS;
   POPULATION-BASED SURVEY; MENTAL-HEALTH-SERVICES; DSM-IV DISORDERS;
   UNITED-STATES; EMERGENCY-DEPARTMENTS; METABOLIC SYNDROME; INSOMNIA;
   TRENDS
AB (1) Background: Limited studies have utilized nationwide data to assess the patterns of psychiatric practice in other countries. In this study, data from the National Health Insurance Research Database in Taiwan (NHIRD-TW) for 2012 was analyzed to determine the patterns of psychiatric outpatient practice in Taiwan; (2) Methods: To determine the patterns of psychiatric outpatient practice in Taiwan, the data were drawn from the datasets of Taiwan's National Health Insurance Research Database for 2012, with 619,760 records of outpatient visits representing 1/500 of all the claims in Taiwan for that year. The analysis of psychiatric outpatient visits included patient demographics, diagnoses, and prescribed medications; (3) Results: Neurotic disorders were the most prevalent diagnoses (43.1%, n = 5714). Hypnotics-sedatives and anxiolytics were prescribed in 51.7% (n = 6850) and 39.1% (n = 5181) of psychiatric visits, respectively, with zolpidem being the most commonly prescribed drug (22.6%, n = 2998); and (4) Conclusion: Hypnotics and sedatives were widely prescribed for the outpatient population, and zolpidem had the highest annual prevalence of use. These findings deserve the attention of clinicians and policy makers for monitoring the abuse and dependence of these agents and subsequent adverse events.
C1 [Dai, Ying-Xiu; Chen, Tzeng-Ji; Lin, Ming-Hwai] Taipei Vet Gen Hosp, Dept Family Med, 201,Sec 2,Shi Pai Rd, Taipei 112, Taiwan.
   [Dai, Ying-Xiu; Chen, Mu-Hong; Chen, Tzeng-Ji; Lin, Ming-Hwai] Natl Yang Ming Univ, Sch Med, 115,Sec 2,Linong St, Taipei 112, Taiwan.
   [Chen, Mu-Hong] Taipei Vet Gen Hosp, Dept Psychiat, 201,Sec 2,Shi Pai Rd, Taipei 112, Taiwan.
C3 Taipei Veterans General Hospital; National Yang Ming Chiao Tung
   University; Taipei Veterans General Hospital
RP Lin, MH (corresponding author), Taipei Vet Gen Hosp, Dept Family Med, 201,Sec 2,Shi Pai Rd, Taipei 112, Taiwan.; Lin, MH (corresponding author), Natl Yang Ming Univ, Sch Med, 115,Sec 2,Linong St, Taipei 112, Taiwan.
EM daiinxiu@gmail.com; kremer7119@gmail.com; tjchen@vghtpe.gov.tw;
   minghwai@gmail.com
RI Chen, MuHong/ACJ-6131-2022; Chen, TJ/AAH-8430-2021
OI Dai, Yuxing/0009-0005-8568-3190; Dai, Ying-Xiu/0000-0002-3279-4509;
   Chen, Tzeng-Ji/0000-0002-8350-0232
FU Ministry of Science and Technology, R.O.C. [MOST 104-2410-H-010-015];
   Taipei Veterans General Hospital [V105E10-002-MY2-1]
FX This study was partially supported by grants from Ministry of Science
   and Technology, R.O.C. (MOST 104-2410-H-010-015) and Taipei Veterans
   General Hospital (V105E10-002-MY2-1).
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NR 49
TC 8
Z9 8
U1 0
U2 2
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD OCT
PY 2016
VL 13
IS 10
AR 955
DI 10.3390/ijerph13100955
PG 10
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA EE4KF
UT WOS:000389570100022
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Freedman, DE
   Richter, MA
AF Freedman, David E.
   Richter, Margaret A.
TI A narrative review of exercise and obsessive-compulsive disorder
SO GENERAL HOSPITAL PSYCHIATRY
LA English
DT Review
DE Obsessive-compulsive disorder; OCD; Anxiety disorders; Exercise;
   Physical activity; Review
ID FACTOR BDNF GENE; AEROBIC EXERCISE; PHYSICAL-ACTIVITY; ANXIETY
   SENSITIVITY; OCD; INTERVENTION; BENEFITS; LIFE; METAANALYSIS; PREVALENCE
AB Objective: Individuals with obsessive-compulsive disorder (OCD) suffer significant distress due to their condition; however, there can be multiple barriers to treatment. Even following OCD-tailored treatment, symptoms often remain. Exercise may be an effective and available approach to managing OCD, and yet, there are no specifically dedicated reviews, limiting integration into clinical practice. This study aimed to provide an overview of the literature on exercise and OCD.
   Method: Four databases, the Cochrane Central Register of Controlled Trials, MEDLINE, PsycINFO, and EMBASE, were systematically searched. 1534 records were screened and the reference lists of eligible articles were examined. For this review, 11 extracted studies were narratively explored.
   Results: Two observational and nine interventional studies were included, of which one article focused on youth and ten studies focused on adults. Physical activity likely reduces the risk of metabolic syndrome or general health conditions. Several pre-post studies demonstrated exercise's benefits for OCD symptoms, while the only randomized controlled trial showed negative findings for its efficacy in reducing obsessions and compulsions.
   Conclusions: The evidence for aerobic exercise's long-term benefits for the symptoms of OCD is mixed, but remains promising. Potential mechanisms of exercise's effects and future directions for research are explored.
C1 [Freedman, David E.; Richter, Margaret A.] Univ Toronto, Sunnybrook Hlth Sci Ctr, Dept Psychiat, Toronto, ON, Canada.
C3 University of Toronto; Sunnybrook Research Institute; Sunnybrook Health
   Science Center
RP Freedman, DE (corresponding author), 2075 Bayview Ave,F109, Toronto, ON M4N 3M5, Canada.
EM david.freedman@sunnybrook.ca
FU CIHR; McLaughlin Centre Accelerator Grants; Labatt Family Innovation
   Fund; Physician Services Inc.
FX Dr. David E. Freedman has no conflicts of interest to report. Dr.
   Margaret A. Richter reports an honorarium from Brainsway, and grant
   funding from CIHR, McLaughlin Centre Accelerator Grants, Labatt Family
   Innovation Fund, and Physician Services Inc.
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NR 73
TC 15
Z9 16
U1 0
U2 27
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0163-8343
EI 1873-7714
J9 GEN HOSP PSYCHIAT
JI Gen. Hosp. Psych.
PD JUL-AUG
PY 2021
VL 71
BP 1
EP 10
DI 10.1016/j.genhosppsych.2021.03.014
EA APR 2021
PG 10
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA TC9KB
UT WOS:000668955100001
PM 33887525
DA 2025-06-11
ER

PT J
AU Li, X
   Hu, CY
   Luo, SS
   Dai, FB
   Li, CY
   Zhou, WJ
   Wang, JW
   Chen, H
   Wang, Z
   Long, TF
   Jiang, L
   Tang, CL
AF Li, Xue
   Hu, Chengyun
   Luo, Shanshan
   Dai, Feibiao
   Li, Chuanyao
   Zhou, Wanjun
   Wang, Jiawu
   Chen, Hao
   Wang, Zhen
   Long, Tengfei
   Jiang, Lai
   Tang, Chaoliang
TI paper Cav3.2 deletion attenuates nonalcoholic fatty liver disease in
   mice
SO GENE
LA English
DT Article
DE Cav3.2; Nonalcoholic fatty liver disease; Oxidative stress; Inflammation
ID CHANNELS; CAMKII
AB Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease and represents the main cause of liver cirrhosis and hepatocellular carcinoma. Cav3.2 is a T-type calcium channel that is widely present in tissues throughout the body and plays a vital role in energy and metabolic balance. However, the effects of Cav3.2 on the NFALD remain unclear. Here, we investigated the role of Cav3.2 channel in the development and progression of NAFLD. After 16 weeks on a high-fat diets (HFD), Cav3.2 knockout (Cav3.2 KO) improved hepatic steatosis, liver injury and metabolic syndrome in an NAFLD mouse model. We provided evidence that Cav3.2 KO inhibited HFD-induced hepatic oxidative stress, inflammation and hepatocyte apoptosis. In addition, Cav3.2 KO also attenuated hepatic lipid accumulation, oxidative stress, inflammation and hepatocyte apoptosis in palmitic acid/oleic acid (PAOA)-treated primary hepatocytes. These results suggest that therapeutic approaches targeting Cav3.2 provide effective approaches for treating NAFLD.
C1 [Li, Xue; Hu, Chengyun; Luo, Shanshan; Dai, Feibiao; Li, Chuanyao; Zhou, Wanjun; Wang, Jiawu; Tang, Chaoliang] Univ Sci & Technol China, Affiliated Hosp USTC 1, Dept Anesthesiol, Div Life Sci & Med, Hefei 230001, Anhui, Peoples R China.
   [Li, Xue; Hu, Chengyun; Luo, Shanshan; Dai, Feibiao; Wang, Jiawu; Tang, Chaoliang] Anhui Prov Canc Hosp, Dept Anesthesiol, Hefei 230031, Anhui, Peoples R China.
   [Chen, Hao] Univ Sci & Technol China, Affiliated Hosp USTC 1, Dept Gen Surg, Div Life Sci & Med, Hefei 230001, Anhui, Peoples R China.
   [Wang, Zhen] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Ultrasound Med, Wuhan 430022, Peoples R China.
   [Long, Tengfei] Univ Sci & Technol China, Affiliated Hosp USTC 1, Hefei Ion Med Ctr, Dept Radiotherapy & Oncol,Div Life Sci & Med, Hefei 230088, Anhui, Peoples R China.
   [Jiang, Lai] Univ Sci & Technol China, Affiliated Hosp USTC 1, Dept Obstet & Gynecol, Div Life Sci & Med, Hefei 230001, Anhui, Peoples R China.
C3 Chinese Academy of Sciences; University of Science & Technology of
   China, CAS; Chinese Academy of Sciences; University of Science &
   Technology of China, CAS; Huazhong University of Science & Technology;
   Chinese Academy of Sciences; University of Science & Technology of
   China, CAS; Chinese Academy of Sciences; University of Science &
   Technology of China, CAS
RP Tang, CL (corresponding author), Univ Sci & Technol China, Affiliated Hosp USTC 1, Dept Anesthesiol, Div Life Sci & Med, Hefei 230001, Anhui, Peoples R China.; Tang, CL (corresponding author), Anhui Prov Canc Hosp, Dept Anesthesiol, Hefei 230031, Anhui, Peoples R China.; Wang, Z (corresponding author), Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Ultrasound Med, Wuhan 430022, Peoples R China.; Long, TF (corresponding author), Univ Sci & Technol China, Affiliated Hosp USTC 1, Hefei Ion Med Ctr, Dept Radiotherapy & Oncol,Div Life Sci & Med, Hefei 230088, Anhui, Peoples R China.; Jiang, L (corresponding author), Univ Sci & Technol China, Affiliated Hosp USTC 1, Dept Obstet & Gynecol, Div Life Sci & Med, Hefei 230001, Anhui, Peoples R China.
EM wangzhen1993@hust.edu.cn; longtengfei@himc.org.cn; gyobjiang@163.com;
   chaolt@ustc.edu.cn
RI Wang, Zhen/GXM-6873-2022; Liu, Shubin/B-1502-2009
OI wang, zhen/0000-0001-9289-4889
FU Anhui Provincial Nat-ural Science Foundation [2208085Y32]; Anhui
   Provincial Depart-ment of Education Scientific Research Project
   [2022AH020076]; Chen Xiao-Ping Foundation for the Development of Science
   and Tech-nology of Hubei Province [CXPJJH12000005-07-115]
FX This study was supported by grants from the Anhui Provincial Nat-ural
   Science Foundation (2208085Y32) , the Anhui Provincial Depart-ment of
   Education Scientific Research Project (2022AH020076) , the Chen
   Xiao-Ping Foundation for the Development of Science and Tech-nology of
   Hubei Province (CXPJJH12000005-07-115)
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NR 62
TC 2
Z9 2
U1 8
U2 9
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0378-1119
EI 1879-0038
J9 GENE
JI Gene
PD DEC 15
PY 2024
VL 929
AR 148812
DI 10.1016/j.gene.2024.148812
EA AUG 2024
PG 10
WC Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Genetics & Heredity
GA D0U8Q
UT WOS:001293431100001
PM 39116959
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Li, F
   Huang, H
   Wu, YK
   Lu, Z
   Zhou, XR
   Tan, F
   Zhao, X
AF Li, Fang
   Huang, Hui
   Wu, Yangkun
   Lu, Zhe
   Zhou, Xianrong
   Tan, Fang
   Zhao, Xin
TI Lactobacillus fermentum HFY06 attenuates d-galactose-induced
   oxidative stress and inflammation in male Kunming mice
SO FOOD & FUNCTION
LA English
DT Article
ID METABOLIC SYNDROME; IMMUNE-RESPONSE; EXPRESSION; PROBIOTICS; DIET
AB There has been considerable research on oxidative stress and inflammation, and their relationship with degenerative diseases. This study investigated the effect of Lactobacillus fermentum HFY06 on aging mice induced by d-galactose. The results showed that L. fermentum HFY06 inhibited the atrophy of the brain, kidneys, liver, and spleen, increased serum SOD, GSH, CAT, and MDA, and decreased IL-6, IL-1 beta, TNF-alpha, and IFN-gamma. Quantitative PCR showed that L. fermentum HFY06 upregulated the expression of Nrf2, gamma-GCS, NOS1, NOS3, SOD1, SOD2, and CAT in the liver and brain tissues, but decreased the expression of NOS2. Western blot analysis showed that L. fermentum HFY06 effectively upregulated the protein expression of SOD1, SOD2, and CAT in the livers and brains of mice. These results suggest that L. fermentum HFY06 can effectively alleviate d-galactose-induced aging in mice, and may activate the Nrf2 signaling pathway and increase the levels of downstream regulatory inflammatory factors and antioxidant enzymes. In conclusion, consumption of L. fermentum HFY06 may prevent aging or reduce oxidative stress.
C1 [Li, Fang; Wu, Yangkun; Lu, Zhe; Zhou, Xianrong; Zhao, Xin] Chongqing Univ Educ, Chongqing Engn Res Ctr Funct Food, Chongqing Collaborat Innovat Ctr Funct Food, Chongqing Engn Lab Res & Dev Funct Food, Chongqing 400067, Peoples R China.
   [Li, Fang; Wu, Yangkun; Lu, Zhe] Chongqing Univ Educ, Coll Biol & Chem Engn, Chongqing 400067, Peoples R China.
   [Huang, Hui] Ninth Peoples Hosp Chongqing, Chongqing 400700, Peoples R China.
   [Tan, Fang] Our Lady Fatima Univ, Dept Publ Hlth, Valenzuela 838, Philippines.
C3 Chongqing University of Education; Chongqing University of Education;
   Our Lady of Fatima University
RP Zhao, X (corresponding author), Chongqing Univ Educ, Chongqing Engn Res Ctr Funct Food, Chongqing Collaborat Innovat Ctr Funct Food, Chongqing Engn Lab Res & Dev Funct Food, Chongqing 400067, Peoples R China.; Tan, F (corresponding author), Our Lady Fatima Univ, Dept Publ Hlth, Valenzuela 838, Philippines.
EM tanfang@foods.ac.cn; zhaoxin@cque.edu.cn
RI Lu, Zhe/GYJ-5494-2022
OI Tan, Fang/0000-0003-2406-129X
FU Chongqing University Innovation Research Group Project [CXQTP20033];
   Science and Technology Project of Chongqing Education Commission
   [KJZD-K202001602]; General Program of Natural Science Foundation of
   Chongqing, China [cstc2021jcyj-msxmX0070]
FX This research was funded by the Chongqing University Innovation Research
   Group Project (CXQTP20033), the Science and Technology Project of
   Chongqing Education Commission (KJZD-K202001602) and the General Program
   of Natural Science Foundation of Chongqing (cstc2021jcyj-msxmX0070),
   China.
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NR 37
TC 15
Z9 16
U1 3
U2 43
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PD DEC 13
PY 2021
VL 12
IS 24
BP 12479
EP 12489
DI 10.1039/d1fo00982f
EA OCT 2021
PG 11
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA XN5RD
UT WOS:000720022900001
PM 34792515
DA 2025-06-11
ER

PT J
AU McGarrity, LA
   Huebner, DM
AF McGarrity, Larissa A.
   Huebner, David M.
TI Is Being Out About Sexual Orientation Uniformly Healthy? The Moderating
   Role of Socioeconomic Status in a Prospective Study of Gay and Bisexual
   Men
SO ANNALS OF BEHAVIORAL MEDICINE
LA English
DT Article
DE Sexual orientation; Health disparities; Socioeconomic status (SES);
   Outness; Disclosure; Concealment
ID PHYSICAL HEALTH; HOMOSEXUAL IDENTITY; MINORITY STRESS; METABOLIC
   SYNDROME; SOCIAL SUPPORT; DISCLOSURE; SYMPTOMS; MODEL; DISCRIMINATION;
   GRADIENT
AB Stress associated with concealing sexual orientation is a possible mechanism for health disparities among lesbian, gay, bisexual (LGB) individuals. However, disclosing one's sexual orientation might not be uniformly healthy across social contexts.
   The present study tested whether being out is less healthy for gay and bisexual men of lower socioeconomic status (SES) relative to higher SES men.
   Using longitudinal data on gay and bisexual men (N = 564, ages 18-72), we examined whether the association between outness and physical health differs by SES.
   SES significantly moderated associations between outness and physician visits, nonprescription medication use, and physical symptoms. Outness predicted physical health benefits for higher SES men but health problems for lower SES men.
   The common assumption that disclosing one's sexual orientation is uniformly healthy may be less accurate (or inaccurate) for lower status groups. Future research should explore SES as context for minority stress and LGB health disparities.
C1 [McGarrity, Larissa A.; Huebner, David M.] Univ Utah, Dept Psychol, Salt Lake City, UT 84112 USA.
C3 Utah System of Higher Education; University of Utah
RP McGarrity, LA (corresponding author), Univ Utah, Dept Psychol, Salt Lake City, UT 84112 USA.
EM larissa.mcgarrity@psych.utah.edu
RI Huebner, David/ABA-2547-2021
OI Huebner, David/0000-0001-6006-5146
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NR 61
TC 76
Z9 97
U1 0
U2 34
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0883-6612
EI 1532-4796
J9 ANN BEHAV MED
JI Ann. Behav. Med.
PD FEB
PY 2014
VL 47
IS 1
BP 28
EP 38
DI 10.1007/s12160-013-9575-6
PG 11
WC Psychology, Multidisciplinary
WE Social Science Citation Index (SSCI)
SC Psychology
GA AB2TX
UT WOS:000331646100004
PM 24307473
OA Bronze
DA 2025-06-11
ER

PT J
AU Perkins, JD
   Wilkins, SS
   Kamran, S
   Shuaib, A
AF Perkins, Jon Davis
   Wilkins, Stacy Schantz
   Kamran, Saadat
   Shuaib, Ashfaq
TI Post-traumatic stress disorder and its association with stroke and
   stroke risk factors: A literature review
SO NEUROBIOLOGY OF STRESS
LA English
DT Review
ID C-REACTIVE PROTEIN; HEART-RATE-VARIABILITY; APOLIPOPROTEIN-E GENOTYPE;
   RENIN-ANGIOTENSIN SYSTEM; CARDIOVASCULAR-DISEASE; ATRIAL-FIBRILLATION;
   METABOLIC SYNDROME; HPA AXIS; PSYCHIATRIC-DISORDERS; ALCOHOL-CONSUMPTION
AB Stroke is a major cause of mortality and disability globally that has multiple risk factors. A risk factor that has recently gained more attention is post-traumatic stress disorder (PTSD).
   Literature searches were carried out for updated PTSD information and for the relationship between PTSD and stroke. The review was divided into two sections, one exploring PTSD as an independent risk factor for stroke, with a second concentrating on PTSD's influence on stroke risk factors.
   The study presents accumulating evidence that shows traumatic stress predicts stroke and is also linked to many major stroke risk factors.
   The review contributes knowledge to stroke aetiology and acts as a reference for understanding the relationship between PTSD and stroke.
   The information presented indicates that screening and identification of traumatic experience would be beneficial for directing stroke patients to appropriate psychological and lifestyle interventions. In doing so, the burden of stroke may be reduced worldwide.
C1 [Perkins, Jon Davis; Kamran, Saadat] Hamad Med Corp, Neurosci Inst, POB 3050, Doha, Qatar.
   [Perkins, Jon Davis] Univ Edinburgh, PMARC, Edinburgh, Midlothian, Scotland.
   [Shuaib, Ashfaq] Univ Alberta, Div Neurol, Edmonton, AB, Canada.
   [Wilkins, Stacy Schantz] Greater Los Angeles VA Med Ctr, Los Angeles, CA USA.
   [Wilkins, Stacy Schantz] Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90095 USA.
   [Kamran, Saadat] Weill Cornell Sch Med, Doha, Qatar.
C3 Hamad Medical Corporation; University of Edinburgh; University of
   Alberta; US Department of Veterans Affairs; Veterans Health
   Administration (VHA); VA Greater Los Angeles Healthcare System;
   University of California System; University of California Los Angeles;
   University of California Los Angeles Medical Center; David Geffen School
   of Medicine at UCLA; Qatar Foundation (QF); Weill Cornell Medical
   College Qatar
RP Perkins, JD (corresponding author), Hamad Med Corp, Neurosci Inst, Acad Hlth, POB 3050, Doha, Qatar.
EM jperkins@hamad.qa
RI Kamran, Saadat/AAG-7499-2019
FU Qatar National Library
FX This research did not receive any specific grant from funding agencies
   in the public, commercial, or not-for-profit sectors. Qatar National
   Library funded the publication of this article.
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NR 269
TC 20
Z9 21
U1 1
U2 14
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 2352-2895
J9 NEUROBIOL STRESS
JI Neurobiol. Stress
PD MAY
PY 2021
VL 14
AR 100332
DI 10.1016/j.ynstr.2021.100332
EA MAY 2021
PG 14
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology
GA SU4AD
UT WOS:000663081700004
PM 34026954
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Sun, YR
   Wang, WJ
   Li, Y
   Wang, HF
   Liang, LN
   Wang, XQ
   Wang, K
   Bai, WP
   Luan, LJ
   Qin, LH
AF Sun, Yanrong
   Wang, Wenjuan
   Li, Yao
   Wang, Hanfei
   Liang, Lining
   Wang, Xiangqiu
   Wang, Ke
   Bai, Wenpei
   Luan, Liju
   Qin, Lihua
TI Unveiling proteomic targets in the hypothalamus of ovariectomized and
   estradiol-treated rats: Insights into menopausal syndrome mechanisms
SO ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER
LA English
DT Article
DE Menopausal syndrome; Hypothalamus; Proteomics; Estrogen; Women's health
ID QUALITY-OF-LIFE; METABOLIC SYNDROME; HOT FLASHES; RISK-FACTOR; WOMEN;
   PREVALENCE; ESTROGEN; 17-BETA-ESTRADIOL; NEUROINFLAMMATION; TRANSITION
AB Background: Menopausal syndrome profoundly affects the physical and mental health of many women, drawing increasing attention from the medical community. However, its pathogenesis remains unclear. These symptoms are primarily driven by hormonal fluctuation. The hypothalamus, a key regulator of hormonal balance, potentially playing a critical role in the manifestation of menopausal syndrome. Methods: We simulated the low-estrogen menopausal state using ovariectomized rats, confirmed the success of ovariectomy via histological analysis of the uterus and vagina, followed by estrogen treatment. TMT-labeled quantitative proteomics, RTqPCR, targeted proteomics and Western blotting were used to identify differentially expressed proteins and their functions in the hypothalamus under low-estrogen conditions. Results: One-way ANOVA (p < 0.05) identified 295 differentially expressed proteins across the sham, ovariectomized and estrogen-treated groups. Post-ovariectomy, 103 differentially expressed proteins were upregulated and 93 were downregulated. Among these, 50 proteins were involved in hormones and neurotransmitters, immunity, metabolism and cardiovascular function. Notably, four proteins-Prkcg, Hsp90ab1, Ywhae, and Gad2-were identified as crucial regulators. Conclusions: This study elucidates the central molecular mechanism of menopausal syndrome through bioinformatics analysis of differentially expressed proteins in the hypothalamus under low-estrogen conditions, providing novel targets for the treatment of related symptoms.
C1 [Sun, Yanrong; Wang, Wenjuan; Wang, Hanfei; Liang, Lining; Wang, Xiangqiu; Wang, Ke; Luan, Liju; Qin, Lihua] Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Dept Human Anat Histol & Embryol, Beijing 100191, Peoples R China.
   [Li, Yao] Qingdao Univ, Affiliated Hosp, Dept Cardiol, Qingdao 266071, Peoples R China.
   [Bai, Wenpei] Capital Med Univ, Beijing Shijitan Hosp, Dept Obstet & Gynecol, Beijing 100038, Peoples R China.
C3 Peking University; Qingdao University; Capital Medical University
RP Luan, LJ; Qin, LH (corresponding author), Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Dept Human Anat Histol & Embryol, Beijing 100191, Peoples R China.; Bai, WP (corresponding author), Capital Med Univ, Beijing Shijitan Hosp, Dept Obstet & Gynecol, Beijing 100038, Peoples R China.
EM baiwp@bjsjth.cn; luanliju@bjmu.edu.cn; qinlihua88@bjmu.edu.cn
FU National Natural Science Foundation of China [81873818, 82171635];
   Natural Science Foundation of Beijing [7232091]; Beijing Hospitals
   Authority Clinical Medicine Development of Special Funding Support
   [ZYLX202112]
FX This work was supported by the grants from the National Natural Science
   Foundation of China (No. 81873818, No. 82171635) , the Natural Science
   Foundation of Beijing (No. 7232091) and Beijing Hospitals Authority
   Clinical Medicine Development of Special Funding Support (No.
   ZYLX202112) .
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NR 66
TC 0
Z9 0
U1 3
U2 5
PU ELSEVIER GMBH
PI MUNICH
PA HACKERBRUCKE 6, 80335 MUNICH, GERMANY
SN 0940-9602
EI 1618-0402
J9 ANN ANAT
JI Ann. Anat.-Anat. Anz.
PD JAN
PY 2025
VL 257
AR 152341
DI 10.1016/j.aanat.2024.152341
EA SEP 2024
PG 17
WC Anatomy & Morphology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Anatomy & Morphology
GA I1O2E
UT WOS:001328012600001
PM 39326767
DA 2025-06-11
ER

PT J
AU Godos, J
   Ferri, R
   Caraci, F
   Cosentino, FII
   Castellano, S
   Galvano, F
   Grosso, G
AF Godos, Justyna
   Ferri, Raffaele
   Caraci, Filippo
   Cosentino, Filomena Irene Ilaria
   Castellano, Sabrina
   Galvano, Fabio
   Grosso, Giuseppe
TI Adherence to the Mediterranean Diet is Associated with Better Sleep
   Quality in Italian Adults
SO NUTRIENTS
LA English
DT Article
DE Mediterranean diet; sleep quality; cognitive decline; dementia; weight
   status; mental health; obesity; cohort; Italy
ID FOOD FREQUENCY QUESTIONNAIRE; PHYSICAL-ACTIVITY; COGNITIVE IMPAIRMENT;
   METABOLIC SYNDROME; LIFE-STYLE; DURATION; METAANALYSIS; LEPTIN; GHRELIN;
   OBESITY
AB Background: Sleep quality has been associated with human health and diseases, including cognitive decline and dementia; however major determinants of sleep disorders are largely unknown. The aim of this study was to evaluate the association between sleep quality and adherence to the Mediterranean dietary pattern in a sample of Italian adults. Methods: A total of 1936 individuals were recruited in the urban area of Catania during 2014-2015 through random sampling. A food frequency questionnaire and validated instruments were used to assess the adherence to the Mediterranean diet and sleep quality (Pittsburg sleep quality index). Multivariate logistic regressions were performed to determine the association between exposure and outcome. Results: A total of 1314 individuals (67.9% of the cohort) reported adequate sleep quality: for each point increase of the Mediterranean diet score, individuals were 10% more likely to have adequate sleep quality. In an additional analysis stratifying the sample by weight status, the association between sleep quality and high adherence to the Mediterranean diet was observed only among normal/overweight individuals but not in obese participants. Conclusions: high adherence to a Mediterranean diet is associated with better sleep quality either toward direct effect on health or indirect effects through improvement of weight status.
C1 [Godos, Justyna; Galvano, Fabio; Grosso, Giuseppe] Univ Catania, Dept Biomed & Biotechnol Sci, I-95123 Catania, Italy.
   [Ferri, Raffaele; Caraci, Filippo; Cosentino, Filomena Irene Ilaria] IRCCS, Oasi Res Inst, I-94018 Troina, Italy.
   [Caraci, Filippo] Univ Catania, Dept Drug Sci, I-95125 Catania, Italy.
   [Castellano, Sabrina] Univ Catania, Dept Educ Sci, I-95124 Catania, Italy.
C3 University of Catania; IRCCS - Oasi Research Institute; University of
   Catania; University of Catania
RP Grosso, G (corresponding author), Univ Catania, Dept Biomed & Biotechnol Sci, I-95123 Catania, Italy.
EM justyna.godos@student.uj.edu.pl; rferri@oasi.en.it; carafil@hotmail.com;
   fcosentino@oasi.en.it; sabrinacastellano@hotmail.it; fgalvano@unict.it;
   giuseppe.grosso@unict.it
RI Castellano, Sabrina/GYI-8462-2022; Galvano, Fabio/JSL-7451-2023; Godos,
   Justyna/AAC-1302-2019; Cosentino, Filomena/C-9873-2017; Ferri,
   Raffaele/B-5439-2013; Grosso, Giuseppe/K-6730-2016; Caraci,
   Filippo/K-2262-2016; Galvano, Fabio/F-8122-2010
OI Godos, Justyna/0000-0002-5809-5706; Cosentino,
   Filomena/0000-0003-1296-9321; Castellano, Sabrina/0009-0002-5470-142X;
   Ferri, Raffaele/0000-0001-6937-3065; Grosso,
   Giuseppe/0000-0003-3930-5285; Caraci, Filippo/0000-0002-9867-6054;
   Galvano, Fabio/0000-0003-0644-0755
FU Italian Ministry of Health "Ricerca Corrente" (RC) [2751594]
FX This study was partially supported by a fund from the Italian Ministry
   of Health "Ricerca Corrente" (RC n. 2751594) (Drs. Ferri, Caraci and
   Cosentino).
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NR 83
TC 99
Z9 104
U1 0
U2 23
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD MAY
PY 2019
VL 11
IS 5
AR 976
DI 10.3390/nu11050976
PG 15
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nutrition & Dietetics
GA IC5PY
UT WOS:000471021600036
PM 31035395
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Barbaresko, J
   Bröder, J
   Conrad, J
   Szczerba, E
   Lang, A
   Schlesinger, S
AF Barbaresko, Janett
   Broeder, Janine
   Conrad, Johanna
   Szczerba, Edyta
   Lang, Alexander
   Schlesinger, Sabrina
TI Ultra-processed food consumption and human health: an umbrella review of
   systematic reviews with meta-analyses
SO CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
LA English
DT Review
DE Health outcomes; NOVA; ultra-processed foods; umbrella review
ID CLASSIFICATION
AB Recently, ultra-processed foods received a lot of attention, but also criticism. Our aim was to provide an overview of the existing evidence of ultra-processed food consumption on human health. We conducted a systematic search in four databases until January 5th, 2024. Systematic reviews with meta-analyses on ultra-processed food consumption as defined by the NOVA classification system were included. The certainty of evidence was evaluated by the GRADE approach. We identified 16 publications. Moderate certainty of evidence was found for all-cause mortality (Summary Risk Ratio per 50 g: 1.02; 95% confidence Interval (CI): 1.01, 1.03), cardiovascular disease incidence and mortality (per 50 g/d: 1.04; 95% CI: 1.02, 1.06, and 1.05; 95% CI: 1.01, 1.08), type 2 diabetes incidence (per 10%: 1.12; 95% CI: 1.10, 1.13) and colorectal cancer (per 10%: 1.04; 95% CI: 1.01, 1.07). For several outcomes such as inflammatory bowel diseases, obesity, metabolic syndrome, nonalcoholic fatty liver disease, mental health as well as nutrient quality, similar estimates were observed, but certainty of evidence was limited. Discussing the NOVA concept, it remains unclear whether the processing of foods leads to increased health risks or if ultra-processed food consumption is only a measure for poor diet quality.
C1 [Barbaresko, Janett; Szczerba, Edyta; Lang, Alexander; Schlesinger, Sabrina] Heinrich Heine Univ, Leibniz Ctr Diabet Res, Inst Biometr & Epidemiol, German Diabet Ctr, Dusseldorf, Germany.
   [Broeder, Janine; Conrad, Johanna] German Nutr Soc, Bonn, Germany.
   [Szczerba, Edyta; Schlesinger, Sabrina] German Ctr Diabet Res DZD, Munich Neuherberg, Germany.
C3 Leibniz Association; Deutsches Diabetes-Zentrum (DDZ); Heinrich Heine
   University Dusseldorf; German Center for Diabetes Research (DZD)
RP Barbaresko, J (corresponding author), Heinrich Heine Univ, Leibniz Ctr Diabet Res, Inst Biometr & Epidemiol, German Diabet Ctr, Dusseldorf, Germany.
EM janett.barbaresko@ddz.de
RI Schlesinger, Sabrina/AAE-7640-2020
OI Conrad, Johanna/0000-0001-5047-1669; Lang,
   Alexander/0000-0002-0584-3213; Schlesinger, Sabrina/0000-0003-4244-0832;
   Schaefer, Edyta/0009-0006-4566-6158
FU German Federal Ministry of Health; Ministry of Science and Culture of
   the State North Rhine-Westphalia; German Federal Ministry of Education
   and Research to the German Center for Diabetes Research (DZD); German
   Nutrition Society - German Federal Ministry of Food and Agriculture
FX Funding: JBa, AL, ES and SS work at the German Diabetes Center (DDZ),
   which is funded by the German Federal Ministry of Health and the
   Ministry of Science and Culture of the State North Rhine-Westphalia.
   This study was supported in part by a grant from the German Federal
   Ministry of Education and Research to the German Center for Diabetes
   Research (DZD). JBr and JC work at the German Nutrition Society, which
   is partly funded by the German Federal Ministry of Food and Agriculture.
   The funder had no role in the decisions about data collection, analyses,
   interpretation of data, or in the writing of the report nor in the
   decision to submit the article for publication.
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NR 49
TC 16
Z9 17
U1 11
U2 40
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1040-8398
EI 1549-7852
J9 CRIT REV FOOD SCI
JI Crit. Rev. Food Sci. Nutr.
PD APR 20
PY 2025
VL 65
IS 11
BP 1999
EP 2007
DI 10.1080/10408398.2024.2317877
EA FEB 2024
PG 9
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA 1AQ0H
UT WOS:001163446900001
PM 38363072
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Baravia, PA
   Qhabibi, FR
   Hadinata, E
   Katuuk, SHH
   Alfaray, RI
   Rampengan, DDCH
   Syahputra, RA
   Taslim, NA
   Tjandrawinata, RR
   Tallei, TE
   Bukhari, A
   Nurkolis, F
AF Baravia, Pirel Aulia
   Qhabibi, Faqrizal Ria
   Hadinata, Edwin
   Katuuk, Steffinna Heronna Helda
   Alfaray, Ricky Indra
   Rampengan, Derren D. C. H.
   Syahputra, Rony Abdi
   Taslim, Nurpudji Astuti
   Tjandrawinata, Raymond Rubianto
   Tallei, Trina Ekawati
   Bukhari, Agussalim
   Nurkolis, Fahrul
TI Algal peptides for future food: Key players and multifaceted agents in
   the fight against cardiometabolic syndrome
SO JOURNAL OF AGRICULTURE AND FOOD RESEARCH
LA English
DT Article
DE Algae; Antioxidant; Cardiometabolic syndrome; Marine peptide;
   Non-communicable disease; Functional food
ID METABOLIC SYNDROME; INHIBITORY PEPTIDES; OXIDATIVE STRESS; ANTIOXIDANTS;
   BIOACTIVITY; MICROALGAE
AB Cardiometabolic syndrome (CMS) is a cluster of metabolic disorders, including obesity, hypertension, oxidative stress, and atherosclerosis, that significantly increase the risk of cardiovascular diseases. Recent studies highlight the therapeutic potential of algae-derived peptides in mitigating these conditions. These bioactive peptides exert anti-obesity effects by enhancing PPAR-gamma activity, reducing white adipose tissue (WAT), and regulating malonylCoA synthesis in hepatocytes, which is essential for lipid metabolism. Additionally, they activate the AMPK pathway, promoting GLUT-4 translocation and improving insulin sensitivity, thereby reducing the risk of type II diabetes. In terms of cardiovascular health, algae peptides demonstrate potent anti-hypertensive properties by inhibiting renin and angiotensin-converting enzyme (ACE), thereby modulating the renin-angiotensinaldosterone system (RAAS) and kallikrein-kinin system (KKS). Furthermore, their strong antioxidant activity mitigates oxidative stress by reducing reactive oxygen species (ROS), protecting endothelial cells, and preventing vascular inflammation. These antioxidant effects contribute to their anti-atherosclerotic potential by suppressing atheroma formation and preserving arterial function.
C1 [Baravia, Pirel Aulia; Qhabibi, Faqrizal Ria] Brawijaya Univ, Fac Med, Dept Cardiol & Vasc Med, Malang 65145, Indonesia.
   [Hadinata, Edwin] Ciputra Hosp Surabaya, Internal Med Dept, Surabaya 60219, Jawa Timur, Indonesia.
   [Katuuk, Steffinna Heronna Helda] Hasanuddin Univ, Fac Med, Dept Internal Med, Makassar 90245, Indonesia.
   [Alfaray, Ricky Indra] Univ Airlangga, Inst Trop Dis, Helicobacter Pylori & Microbiota Study Grp, Surabaya 60286, Indonesia.
   [Rampengan, Derren D. C. H.] Univ Sam Ratulangi, Fac Med, Manado, Indonesia.
   [Syahputra, Rony Abdi] Univ Sumatera Utara, Fac Pharm, Dept Pharmacol, Medan 20155, Indonesia.
   [Taslim, Nurpudji Astuti; Bukhari, Agussalim] Hasanuddin Univ, Fac Med, Dept Nutrititon, Div Clin Nutr, Makassar, Indonesia.
   [Tjandrawinata, Raymond Rubianto] Atma Jaya Catholic Univ Indonesia, Ctr Pharmaceut & Nutraceut Res & Policy, Jakarta 12930, Indonesia.
   [Tallei, Trina Ekawati] Sam Ratulangi Univ, Fac Math & Nat Sci, Dept Biol, Manado 95115, Indonesia.
   [Nurkolis, Fahrul] State Islamic Univ Sunan Kalijaga UIN Sunan Kalija, Yogyakarta 55281, Indonesia.
   [Nurkolis, Fahrul] Univ Airlangga, Fac Med, Master Program Basic Med Sci, Surabaya, Indonesia.
   [Alfaray, Ricky Indra; Nurkolis, Fahrul] Bioinformat Res Ctr, Malang, Indonesia.
C3 Brawijaya University; Universitas Hasanuddin; Airlangga University;
   Universitas Sam Ratulangi; University of North Sumatra; Universitas
   Hasanuddin; University Katolik Indonesia Atma Jaya; Universitas Sam
   Ratulangi; Airlangga University
RP Syahputra, RA (corresponding author), Univ Sumatera Utara, Dept Pharmacol, Medan 20155, Indonesia.
EM pirelaulia@gmail.com; faqrizalhabib2628@gmail.com;
   edwin.hadinata@yahoo.com; steffinnakatuuk@gmail.com;
   rickyindraalfaray@gmail.com; derrenrmed@gmail.com; rony@usu.ac.id;
   pudji_taslim@yahoo.com; raytjan@yahoo.com; trina_tallei@unsrat.ac.id;
   agussalim.bukhari@med.unhas.ac.id; fahrul.nurkolis.mail@gmail.com
RI Bukhari, Agussalim/R-9284-2019; Tjandrawinata, Raymond/F-1889-2013;
   Nurkolis, Fahrul/AAY-1874-2021; Taslim, Nurpduji/AAP-3464-2021; Alfaray,
   Ricky/JDV-5336-2023; Qhabibi, Faqrizal Ria/GSI-4757-2022; Tallei, Trina
   Ekawati/U-1322-2019
OI Qhabibi, Faqrizal Ria/0000-0001-5320-358X; Tallei, Trina
   Ekawati/0000-0002-7963-7527
FU Universitas Sumatera Utara
FX Visualization. Funding This study was supported by Universitas Sumatera
   Utara.
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NR 80
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2666-1543
J9 J AGR FOOD RES
JI J. Agric. Food Res.
PD APR
PY 2025
VL 20
AR 101786
DI 10.1016/j.jafr.2025.101786
EA MAR 2025
PG 12
WC Agriculture, Multidisciplinary; Food Science & Technology
WE Emerging Sources Citation Index (ESCI)
SC Agriculture; Food Science & Technology
GA Z7V2R
UT WOS:001440930200001
DA 2025-06-11
ER

PT J
AU Gentile, G
   Negro, A
   D'Alonzo, L
   Aimati, L
   Simmaco, M
   Martelletti, P
   Borro, M
AF Gentile, Giovanna
   Negro, Andrea
   D'Alonzo, Lidia
   Aimati, Laura
   Simmaco, Maurizio
   Martelletti, Paolo
   Borro, Marina
TI Lack of association between oxidative stress-related gene polymorphisms
   and chronic migraine in an Italian population
SO EXPERT REVIEW OF NEUROTHERAPEUTICS
LA English
DT Review
DE chronic migraine; gene polymorphisms; oxidative stress
ID MAGNETIC-RESONANCE-SPECTROSCOPY; S-TRANSFERASE POLYMORPHISMS; HIGH-DOSE
   RIBOFLAVIN; C-REACTIVE PROTEIN; DOUBLE-BLIND; MITOCHONDRIAL DYSFUNCTION;
   SUPEROXIDE-DISMUTASE; DENSITY-LIPOPROTEIN; ENERGY-METABOLISM;
   PROPHYLAXIS
AB Migraine patients present increased risks of vascular diseases such as high blood pressure, insulin resistance, metabolic syndrome, stroke and coronary heart disease. Oxidative stress (OS) is increasingly being studied in relation to the pathophysiology of migraine, stimulated by the described association with the most frequent migraine comorbidities. Because many of the gene-encoded players of the OS balance are characterized by functional polymorphisms, it is supposed that the individual genomic profile could affect susceptibility to OS and to related pathophysiological conditions. This study aimed to characterize a panel of 10 polymorphisms in 8 OS-related genes in a chronic migraine (CM) population and healthy controls, to recognize a genetic risk in the process of migraine chronification. The sample consisted of 45 healthy women and 96 women diagnosed with CM. No deviations from the Hardy-Weinberg equilibrium were detected, or in the overall population, or in the CM group or in the control group.
C1 [Gentile, Giovanna; Aimati, Laura; Simmaco, Maurizio; Borro, Marina] St Andrea Hosp, Adv Mol Diagnost Unit, Rome, Italy.
   [Gentile, Giovanna; Simmaco, Maurizio; Borro, Marina] Univ Roma La Sapienza, NESMOS Dept, I-00185 Rome, Italy.
   [Negro, Andrea; Martelletti, Paolo] Univ Roma La Sapienza, Dept Clin & Mol Med, I-00185 Rome, Italy.
   [D'Alonzo, Lidia; Martelletti, Paolo] St Andrea Hosp, Reg Referral Headache Ctr, Rome, Italy.
C3 Sapienza University Rome; Azienda Ospedaliera Sant'Andrea; Sapienza
   University Rome; Sapienza University Rome; Sapienza University Rome;
   Azienda Ospedaliera Sant'Andrea
RP Martelletti, P (corresponding author), Univ Roma La Sapienza, Dept Clin & Mol Med, Piazzale Aldo Moro 5, I-00185 Rome, Italy.
EM paolo.martelletti@uniroma1.it
RI Simmaco, Maurizio/AAC-2870-2019; BORRO, Marina/Q-1190-2016; Gentile,
   giovanna/M-3565-2016
OI Negro, Andrea/0000-0003-3590-298X; BORRO, Marina/0000-0002-7839-9125;
   Martelletti, Paolo/0000-0002-6556-4128; Gentile,
   giovanna/0000-0001-8667-3094
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NR 89
TC 10
Z9 10
U1 0
U2 13
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1473-7175
EI 1744-8360
J9 EXPERT REV NEUROTHER
JI Expert Rev. Neurother.
PD FEB
PY 2015
VL 15
IS 2
BP 215
EP 225
DI 10.1586/14737175.2015.1001748
PG 11
WC Clinical Neurology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pharmacology & Pharmacy
GA AZ8HM
UT WOS:000348456300009
PM 25585507
DA 2025-06-11
ER

PT J
AU Vancampfort, D
   Probst, M
   Sweers, K
   Maurissen, K
   Knapen, J
   Willems, B
   Heip, T
   De Hert, M
AF Vancampfort, D.
   Probst, M.
   Sweers, K.
   Maurissen, K.
   Knapen, J.
   Willems, B.
   Heip, T.
   De Hert, M.
TI Eurofit test battery in patients with schizophrenia or schizoaffective
   disorder: Reliability and clinical correlates
SO EUROPEAN PSYCHIATRY
LA English
DT Article
DE Physical Fitness; Eurofit; Schizophrenia; Reliability
ID ALL-CAUSE MORTALITY; PHYSICAL-FITNESS; METABOLIC SYNDROME;
   CARDIORESPIRATORY FITNESS; ATYPICAL ANTIPSYCHOTICS; SAMPLE-SIZE;
   HEALTHY; SMOKING; WEIGHT; OBESE
AB Objective: To investigate the reproducibility of the Eurofit physical fitness test battery in patients with schizophrenia or schizoaffective disorder. Secondary aims were to assess clinical and demographic characteristics that correlate with the performance on the Eurofit and evaluation of the feasibility of the test.
   Methods: Fifty patients with schizophrenia or schizoaffective disorder (mean age of 32.9 +/- 9.5 years) with a mean body mass index (BMI) of 26.1 +/- 6.0 kg/m(2) performed two Eurofit tests administered within 3 days.
   Results: All Eurofit items showed good reproducibility with intraclass correlation coefficients ranging from 0.72 for flamingo balance to 0.98 for standing broad jump test. All participants could perform five of the seven test items without problems. The whole body balance and abdominal muscle endurance test could be executed by 74 and 90%, respectively. Significant correlations were found with age, BMI, waist circumference, dose of antipsychotic medication and extrapyramidal, negative and cognitive symptoms.
   Conclusions: The Eurofit test showed good reproducibility and can be recommended for evaluating physical fitness parameters in patients with schizophrenia or schizoaffective disorder. Physical fitness measures were related to both physical and mental health parameters. (C) 2011 Elsevier Masson SAS. All rights reserved.
C1 [Vancampfort, D.; Probst, M.; Sweers, K.; Maurissen, K.; Knapen, J.; Willems, B.; Heip, T.; De Hert, M.] Katholieke Univ Leuven, Univ Psychiat Ctr, B-3070 Kortenberg, Belgium.
   [Vancampfort, D.; Probst, M.; Maurissen, K.; Knapen, J.] Katholieke Univ Leuven, Fac Kinesiol & Rehabil Sci, Louvain, Belgium.
   [De Hert, M.] Katholieke Univ Leuven, Fac Med, Louvain, Belgium.
C3 KU Leuven; KU Leuven; KU Leuven
RP Vancampfort, D (corresponding author), Katholieke Univ Leuven, Univ Psychiat Ctr, Campus Kortenberg,Leuvensesteenweg 517, B-3070 Kortenberg, Belgium.
EM Davy.Vancampfort@uc-kortenberg.be
RI De Hert, Marc/AAH-6090-2021; Vancampfort, Davy/AAD-1987-2019; Probst,
   Michel/ABE-6137-2020
OI De Hert, Marc/0000-0003-4255-5920
FU Astra Zeneca; Bristol-Myers Squibb; Eli Lilly; Janssen-Cilag; Lundbeck;
   Pfizer; Sanofi-Aventis
FX M. De Hert has been a consultant for, received grant/research support
   and honoraria from, and has been on the Astra Zeneca, Bristol-Myers
   Squibb, Eli Lilly, Janssen-Cilag, Lundbeck, Pfizer and Sanofi-Aventis.
   He did not receive a financial compensation for writing the article. The
   other authors declare that they have no conflicts of interest to
   disclose relative to the article and did not receive a financial
   compensation for writing the article.
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NR 44
TC 27
Z9 31
U1 1
U2 23
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0924-9338
EI 1778-3585
J9 EUR PSYCHIAT
JI Eur. Psychiat.
PD AUG
PY 2012
VL 27
IS 6
BP 416
EP 421
DI 10.1016/j.eurpsy.2011.01.009
PG 6
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 974ZP
UT WOS:000306476500006
PM 21398095
DA 2025-06-11
ER

PT J
AU Rusciano, D
AF Rusciano, Dario
TI Health Benefits of Epigallocatechin Gallate and Forskolin with a Special
   Emphasis on Glaucoma and Other Retinal Diseases
SO MEDICINA-LITHUANIA
LA English
DT Review
DE epigallocatechin gallate; forskolin; eye; retinal disease; glaucoma;
   macular degeneration; diabetic retinopathy
ID LOWERS INTRAOCULAR-PRESSURE; GREEN TEA CATECHIN; (-)-EPIGALLOCATECHIN
   GALLATE; ENDOTHELIAL-CELLS; OXIDATIVE STRESS; GANGLION-CELLS; MOUSE
   MODEL; METABOLIC SYNDROME; INDUCED APOPTOSIS; OPTIC-NERVE
AB This review highlights the therapeutic potential of epigallocatechin gallate (EGCG) and forskolin in managing retinal diseases, with a focus on glaucoma, age-related macular degeneration (AMD), and diabetic retinopathy. EGCG, a potent polyphenol from green tea, exhibits significant antioxidant, anti-inflammatory, and neuroprotective effects, making it a promising candidate for reducing oxidative stress and inflammation in ocular tissues. Forskolin, a diterpene from Coleus forskohlii, increases cyclic AMP (cAMP) levels, which helps lower intraocular pressure (IOP) and provides neuroprotection. Both compounds target critical pathways involved in retinal disease progression, including oxidative stress, mitochondrial dysfunction, and inflammation, offering complementary therapeutic benefits. This review consolidates preclinical and clinical studies, highlighting the potential of EGCG and forskolin as adjunctive or alternative treatments for retinal diseases. Future research should explore the synergistic effects of these compounds, particularly in combination therapies aimed at addressing multiple pathogenic mechanisms in retinal health.
C1 [Rusciano, Dario] Fidia Ophthalm, I-95124 Catania, Italy.
RP Rusciano, D (corresponding author), Fidia Ophthalm, I-95124 Catania, Italy.
EM drusciano55@gmail.com
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NR 164
TC 1
Z9 1
U1 1
U2 1
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1010-660X
EI 1648-9144
J9 MEDICINA-LITHUANIA
JI Med. Lith.
PD DEC
PY 2024
VL 60
IS 12
AR 1957
DI 10.3390/medicina60121957
PG 23
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA Q4W8Q
UT WOS:001384711800001
PM 39768839
OA gold
DA 2025-06-11
ER

PT J
AU Manzoor, MF
   Arif, Z
   Kabir, A
   Mehmood, I
   Munir, D
   Razzaq, A
   Ali, A
   Goksen, G
   Cosier, V
   Ahmad, N
   Ali, M
   Rusu, A
AF Manzoor, Muhammad Faisal
   Arif, Zaira
   Kabir, Asifa
   Mehmood, Iqra
   Munir, Danial
   Razzaq, Aqsa
   Ali, Anwar
   Goksen, Gulden
   Cosier, Viorica
   Ahmad, Nazir
   Ali, Murtaza
   Rusu, Alexandru
TI Oxidative stress and metabolic diseases: Relevance and therapeutic
   strategies
SO FRONTIERS IN NUTRITION
LA English
DT Review
DE oxidative stress; metabolic diseases; a burden on health; therapeutic
   approaches; LDL
ID LOW-DENSITY-LIPOPROTEIN; GLYCATION END-PRODUCTS; INSULIN-RESISTANCE;
   OXIDIZED LDL; RISK-FACTORS; PATHOGENESIS; CARNOSINE; OBESITY;
   DYSLIPIDEMIA; INHIBITION
AB Metabolic syndrome (MS) is a prominent cause of death worldwide, posing a threat to the global economy and public health. A mechanism that causes the oxidation of low-density lipoproteins (LDL) is associated with metabolic abnormalities. Various processes are involved in oxidative stress (OS) of lipoprotein. Although the concept of the syndrome has been fiercely debated, this confluence of risk factors is associated with a higher chance of acquiring type 2 diabetes mellitus (T2DM) and atherosclerosis. Insulin resistance has been found to play a significant role in the progression of these metabolism-associated conditions. It causes lipid profile abnormalities, including greater sensitivity to lipid peroxidation, contributing to the increased prevalence of T2DM and atherosclerosis. This review aims to cover the most recent scientific developments in dietary OS, the consequence of metabolic disorders, and their most significant clinical manifestations (T2DM and atherosclerosis). It will also emphasize the effects of dietary approaches in alleviating OS in MS.
C1 [Manzoor, Muhammad Faisal; Ali, Murtaza] Foshan Univ, Guangdong Prov Key Lab Intelligent Food Mfg, Foshan, Peoples R China.
   [Manzoor, Muhammad Faisal; Ali, Murtaza] South China Univ Technol, Sch Food Sci & Engn, Guangzhou, Peoples R China.
   [Arif, Zaira; Kabir, Asifa; Mehmood, Iqra; Munir, Danial; Razzaq, Aqsa; Ahmad, Nazir] Govt Coll Univ, Fac Med Sci, Dept Nutr Sci, Faisalabad, Pakistan.
   [Ali, Anwar] Cent South Univ, Xiangya Sch Publ Hlth, Dept Epidemiol & Hlth Stat, Changsha, Peoples R China.
   [Ali, Anwar] Cent South Univ, Xiangya Sch Publ Hlth, Hunan Prov Key Lab Clin Epidemiol, Changsha, Peoples R China.
   [Goksen, Gulden] Tarsus Univ, Vocat Sch Tech Sci, Dept Food Technol, Mersin Tarsus Organized Ind Zone, Mersin, Turkey.
   [Cosier, Viorica; Rusu, Alexandru] Univ Agr Sci & Vet Med Cluj Napoca, Anim Sci & Biotechnol Fac, Genet & Genet Engn Dept, Cluj Napoca, Romania.
   [Rusu, Alexandru] Univ Agr Sci & Vet Med Cluj Napoca, Life Sci Inst, Cluj Napoca, Romania.
C3 Foshan University; South China University of Technology; Government
   College University Faisalabad; Central South University; Central South
   University; Tarsus University; University of Agricultural Sciences &
   Veterinary Medicine Cluj Napoca; University of Agricultural Sciences &
   Veterinary Medicine Cluj Napoca
RP Ali, M (corresponding author), Foshan Univ, Guangdong Prov Key Lab Intelligent Food Mfg, Foshan, Peoples R China.; Ali, M (corresponding author), South China Univ Technol, Sch Food Sci & Engn, Guangzhou, Peoples R China.; Ahmad, N (corresponding author), Govt Coll Univ, Fac Med Sci, Dept Nutr Sci, Faisalabad, Pakistan.; Rusu, A (corresponding author), Univ Agr Sci & Vet Med Cluj Napoca, Anim Sci & Biotechnol Fac, Genet & Genet Engn Dept, Cluj Napoca, Romania.; Rusu, A (corresponding author), Univ Agr Sci & Vet Med Cluj Napoca, Life Sci Inst, Cluj Napoca, Romania.
EM drnazirahmad@gcuf.edu.pk; alimurtaza@aup.edu.pk;
   rusu_alexandru@hotmail.com
RI Manzoor, Muhammad Faisal/AAJ-2767-2021; Rusu, Alexandru/AAI-2282-2020;
   ALI, ANWAR/ADP-3857-2022; Ali, Murtaza/GSD-3325-2022; Goksen,
   Gulden/GQQ-1993-2022
OI Ali, Murtaza/0000-0002-5020-7398; Goksen, Gulden/0000-0002-5432-7936;
   Ali, Anwar/0000-0003-3169-1804
FU Romanian National Authority for Scientific Research and Innovation,
   CNCS-UEFISCDI within PNCDI III [PN-III-P2-2.1-PED-2019-1723, PFE 14];
   Guangdong Provincial Key Laboratory of Intelligent Food Manufacturing,
   Foshan University, Foshan, China [2022B1212010015]
FX This study was supported by a grant from the Romanian National Authority
   for Scientific Research and Innovation, CNCS-UEFISCDI, Project Number
   PN-III-P2-2.1-PED-2019-1723 and PFE 14, within PNCDI III. The authors
   also want to acknowledge the support of Guangdong Provincial Key
   Laboratory of Intelligent Food Manufacturing, Foshan University, Foshan
   528225, China (Project ID:2022B1212010015).
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NR 104
TC 20
Z9 22
U1 2
U2 13
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD OCT 17
PY 2022
VL 9
AR 994309
DI 10.3389/fnut.2022.994309
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 5W8XM
UT WOS:000878192300001
PM 36324618
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Rico, D
   Martin-Diana, AB
   Lasa, A
   Aguirre, L
   Milton-Laskibar, I
   de Luis, DA
   Miranda, J
AF Rico, Daniel
   Belen Martin-Diana, Ana
   Lasa, Arrate
   Aguirre, Leixuri
   Milton-Laskibar, Inaki
   Antonio de Luis, Daniel
   Miranda, Jonatan
TI Effect of Wakame and Carob Pod Snacks on Non-Alcoholic Fatty Liver
   Disease
SO NUTRIENTS
LA English
DT Article
DE wakame; carob; snack; steatohepatitis; NAFLD
ID OXIDATIVE STRESS; BROWN SEAWEED; RATS; EXPRESSION; STEATOHEPATITIS;
   EPIDEMIOLOGY; RESVERATROL; COMBINATION; QUERCETIN; FRUCTOSE
AB Snacks combining different functional ingredients could represent a useful therapeutic strategy against NAFLD. The present study aimed to analyze the effect of two snack formulations based on carob and wakame flour in the treatment for NAFLD in rats. For this purpose, metabolic syndrome was induced in 50 adult rats by a high-fat high-fructose diet over eight weeks. After this period, rats were fed either normal calorie diets supplemented or not with snack A (1/50 wakame/carob pod) and snack B (1/5 wakame/carob pod) for four additional weeks. After sacrifice, liver composition and serum parameters were analyzed. Different pathways of triacylglycerol metabolism in liver were studied including fatty acid oxidation, fatty acid synthesis, triglyceride assembly and release, fatty acid uptake and glucose uptake. Oxidative stress was also measured. Snack treatment, and mainly B snack, reduced liver triacylglycerol levels by increasing fat oxidation. Moreover, this snack reduced oxidative stress. Therefore, this snack formulation could represent an interesting tool useful for fatty liver treatment.
C1 [Rico, Daniel; Belen Martin-Diana, Ana] Govt Castilla & Leon, Dept Res & Technol, Agr Technol Inst Castilla & Leon ITACyL, Ctra Burgos Km 119, Valladolid 47071, Spain.
   [Lasa, Arrate; Aguirre, Leixuri; Milton-Laskibar, Inaki; Miranda, Jonatan] Univ Basque Country UPV EHU, Fac Pharm, Dept Nutr & Food Sci, Nutr & Obes Grp, Vitoria 01006, Spain.
   [Lasa, Arrate; Aguirre, Leixuri; Milton-Laskibar, Inaki; Miranda, Jonatan] Lucio Lascaray Res Ctr, Vitoria 01006, Spain.
   [Lasa, Arrate; Aguirre, Leixuri; Milton-Laskibar, Inaki; Miranda, Jonatan] Inst Hlth Carlos III ISCIII, CIBEROBN Physiopathol Obes & Nutr, Vitoria 01006, Spain.
   [Antonio de Luis, Daniel] Univ Valladolid, Endocrinol & Nutr Dept, Hosp Clin Univ Valladolid IEN, Fac Med, E-47005 Valladolid, Spain.
C3 University of Basque Country; CIBER - Centro de Investigacion Biomedica
   en Red; CIBEROBN; Universidad de Valladolid
RP Lasa, A (corresponding author), Univ Basque Country UPV EHU, Fac Pharm, Dept Nutr & Food Sci, Nutr & Obes Grp, Vitoria 01006, Spain.; Lasa, A (corresponding author), Lucio Lascaray Res Ctr, Vitoria 01006, Spain.; Lasa, A (corresponding author), Inst Hlth Carlos III ISCIII, CIBEROBN Physiopathol Obes & Nutr, Vitoria 01006, Spain.
EM ricbarda@itacyl.es; mardiaan@itacyl.es; arrate.lasa@ehu.eus;
   leixuri.aguirre@ehu.eus; inaki.milton@ehu.eus; dadluis@yahoo.es;
   jonatan.miranda@ehu.eus
RI aguirre, leixuri/ABH-2354-2020; de luis roman, Daniel/HKN-3846-2023;
   Lasa, Arrate/L-7549-2014; Miranda, Jonatan/F-3289-2011; Rico,
   Daniel/AAV-5368-2020; Milton, Iñaki/HFZ-8950-2022; Martin-Diana, Ana
   Belen/E-5825-2012; Miranda, Jonatan/L-4511-2014
OI Martin-Diana, Ana Belen/0000-0001-5014-9848; Aguirre,
   Leixuri/0000-0002-6965-4358; Rico, Daniel/0000-0002-0755-3033; de Luis,
   Daniel/0000-0002-1745-9315; LASA ELGUEZUA, ARRATE/0000-0002-8309-8212;
   Milton-Laskibar, Inaki/0000-0003-4312-9720; Miranda,
   Jonatan/0000-0002-5484-2671
FU National Institute for Agricultural and Food Research and Technology of
   Spain [INIA: RTA2014-0037-C02]; Instituto de Salud Carlos III
   (CIBERobn); Basque Government [IT-572-13]
FX This study has been supported by the National Institute for Agricultural
   and Food Research and Technology of Spain (INIA: RTA2014-0037-C02),
   Instituto de Salud Carlos III (CIBERobn) and Basque Government
   (IT-572-13).
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NR 38
TC 10
Z9 10
U1 3
U2 18
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JAN
PY 2019
VL 11
IS 1
AR 86
DI 10.3390/nu11010086
PG 14
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA HJ8VI
UT WOS:000457477800058
PM 30621142
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Molina-Sotomayor, E
   Arreguín-Moreno, R
   Rodríguez, F
   Pradas, F
   León, JA
   González-Jurado, JA
AF Molina-Sotomayor, Edgardo
   Arreguin-Moreno, Rocio
   Rodriguez, Fernando
   Pradas, Francisco
   Antonio Leon, Juan
   Antonio Gonzalez-Jurado, Jose
TI Effects of exercise on the cognition of older women treated with
   lovastatin
SO BIOMEDICA
LA English
DT Article
DE Exercise; cognition; dyslipidemia; hydroxymethylglutaryl- CoA reductase
   inhibitors; mental health; aging
ID 6-MINUTE WALK TEST; DENSITY-LIPOPROTEIN CHOLESTEROL; MINI-MENTAL-STATE;
   QUALITY-OF-LIFE; AEROBIC EXERCISE; BLOOD-LIPIDS; METABOLIC SYNDROME;
   PHYSICAL-ACTIVITY; METAANALYSIS; IMPAIRMENT
AB Introduction: The deterioration of cognition is highly predominant in older adults.
   Objective: The aim of this study was to analyse the effects of a walk program on the cognition and blood concentration of lipids in women over 60 years of age who were being treated with Lovastatin.
   Materials and methods: Participants were distributed in two groups: an exercise group (EG, n=45) with aerobic training and an inactive sedentary group (SG, n=22). The cognitive state of the subjects was assessed through the Spanish Mini-Cog Test version of the MMSE; lipoproteins were quantified using a lipid profile test and the cardiorespiratory fitness was measured using the 6 min Walk Test (6MWT).
   Results: EG showed a significant increase (p<0.05) in cardiorespiratory fitness and in HDL-C concentrations. Furthermore, the results from the cognition tests showed a large effect size in spatial orientation and attention and calculation. The decrease in LDL-C was not significant (p>0.05).
   Conclusion: A controlled and progressive walk program for older women treated with Lovastatin may induce a boost of brain activity linked to HDL-C, which could delay cognitive impairment.
C1 [Molina-Sotomayor, Edgardo; Rodriguez, Fernando] Univ Metropolitana Ciencias Educ, Dept Educ Fis, Santiago, Chile.
   [Arreguin-Moreno, Rocio] Univ Sonora, Dept Psicol & Ciencias Comunicac, Hermosillo, Sonora, Mexico.
   [Pradas, Francisco] Univ Zaragoza, Dept Expres Mus Plast & Corporal, Zaragoza, Spain.
   [Antonio Leon, Juan; Antonio Gonzalez-Jurado, Jose] Univ Pablo de Olavide, Fac Ciencias Deporte, Carretera Utrera Km 1, Seville 41013, Spain.
C3 Universidad Metropolitana de Ciencias de la Educacion (UMCE);
   Universidad de Sonora; University of Zaragoza; Universidad Pablo de
   Olavide
RP González-Jurado, JA (corresponding author), Univ Pablo de Olavide, Fac Ciencias Deporte, Carretera Utrera Km 1, Seville 41013, Spain.
EM jagonjur@upo.es
RI Pradas de la Fuente, Francisco/JCE-4701-2023; Leon-Prados,
   Juan/HLH-0679-2023; Gonzalez-Jurado, Jose/C-2843-2015; Molina Sotomayor,
   Edgardo/A-2195-2019
OI Molina Sotomayor, Edgardo/0000-0002-0362-6960
FU Direction of Research of Universidad Metropolitana de Ciencias de la
   Educacion (Santiago de Chile)
FX This study was funded by Direction of Research of Universidad
   Metropolitana de Ciencias de la Educacion (Santiago de Chile).
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NR 78
TC 1
Z9 1
U1 0
U2 0
PU INST NACIONAL SALUD - Colombia
PI BOGOTA D C
PA AVENIDA CALLE 26 NO 51-60, APARTADO AEREO 80334 Y 80080, BOGOTA D C,
   00000, COLOMBIA
SN 0120-4157
EI 2590-7379
J9 BIOMEDICA
JI Biomedica
PD DEC
PY 2018
VL 38
IS 4
PG 33
WC Tropical Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Tropical Medicine
GA GZ5JO
UT WOS:000449455600014
DA 2025-06-11
ER

PT J
AU Vanasse, A
   Blais, L
   Courteau, J
   Cohen, AA
   Roberge, P
   Larouche, A
   Grignon, S
   Fleury, MJ
   Lesage, A
   Demers, MF
   Roy, MA
   Carrier, JD
   Delorme, A
AF Vanasse, A.
   Blais, L.
   Courteau, J.
   Cohen, A. A.
   Roberge, P.
   Larouche, A.
   Grignon, S.
   Fleury, M-J.
   Lesage, A.
   Demers, M-F.
   Roy, M-A.
   Carrier, J-D.
   Delorme, A.
TI Comparative effectiveness and safety of antipsychotic drugs in
   schizophrenia treatment: a real-world observational study
SO ACTA PSYCHIATRICA SCANDINAVICA
LA English
DT Article
DE real-world study; schizophrenia; antipsychotic drugs; relative
   effectiveness; safety; discontinuation
ID PRESCRIPTION CLAIMS DATABASE; ATYPICAL ANTIPSYCHOTICS; METABOLIC
   SYNDROME; CLINICAL-TRIALS; DISCONTINUATION; METAANALYSIS; EFFICACY;
   ILLNESS; QUEBEC; COMORBIDITY
AB Objective: The objective was to compare, in a real-world setting, the risk of mental and physical health events associated with different antipsychotic drugs (clozapine, olanzapine, risperidone, quetiapine and first-generation antipsychotics) in patients with SZ.
   Methods: This is a retrospective cohort study using administrative data. Outcome measures included any mental health event (suicide, hospitalization or emergency visit for mental disorders) and physical health event (death other than suicide, hospitalization or emergency visit for physical disorders). Cox proportional hazard models were used to estimate the hazard ratios of the events associated with the use of the different antipsychotic drugs.
   Results: The cohort included 18 869 adult patients living in the province of Quebec (Canada) with SZ and starting antipsychotic drugs between January 1998 and December 2005. Results show that quetiapine and not using any antipsychotics were associated with an increased risk of mental and physical health events as compared to other drugs. The second finding is the confirmation of better performance of clozapine. The results were robust across sensitivity analyses.
   Conclusion: Both findings call for an international public health and drug agencies surveillance of 'real-world' antipsychotic medication to ensure the optimal choices in treatment guidelines for SZ.
C1 [Vanasse, A.; Courteau, J.; Cohen, A. A.; Roberge, P.] Univ Sherbrooke, Dept Med Famille & Med Urgence, 3001 12th Ave North, Sherbrooke, PQ J1H 5N4, Canada.
   [Vanasse, A.; Courteau, J.; Cohen, A. A.; Roberge, P.; Larouche, A.; Carrier, J-D.] Univ Sherbrooke, CHUS, Ctr Rech, PRIMUS Grp, Sherbrooke, PQ, Canada.
   [Blais, L.] Univ Montreal, Fac Med, Montreal, PQ, Canada.
   [Grignon, S.] Univ Sherbrooke, Dept Psychiat, Sherbrooke, PQ, Canada.
   [Fleury, M-J.] McGill Univ, Douglas Mental Hlth Univ Inst, Montreal, PQ, Canada.
   [Lesage, A.] Inst Univ Sante Mentale Montreal, Ctr Rech, Montreal, PQ, Canada.
   [Demers, M-F.] Univ Laval, Fac Pharm, Quebec City, PQ, Canada.
   [Demers, M-F.; Roy, M-A.] CRIUSMQ, Quebec City, PQ, Canada.
   [Delorme, A.] Minist Sante & Serv Sociaux Quebec, Direct Sante Mentale, Quebec City, PQ, Canada.
C3 University of Sherbrooke; University of Sherbrooke; Universite de
   Montreal; University of Sherbrooke; McGill University; Universite de
   Montreal; Laval University
RP Vanasse, A (corresponding author), Univ Sherbrooke, Dept Med Famille & Med Urgence, 3001 12th Ave North, Sherbrooke, PQ J1H 5N4, Canada.
EM Alain.Vanasse@Usherbrooke.ca
RI Roberge, Pasquale/H-6090-2016; Carrier, Jean-Daniel/HNR-8897-2023
OI Demers, Marie-France/0000-0002-4045-9890; Cohen,
   Alan/0000-0003-4113-3988
FU Canadian Institutes of Health Research (CIHR) [311143]; Fonds de
   Recherche du Quebec - Sante; Department of Family Medicine and Emergency
   medicine, Universite de Sherbrooke
FX This work was supported by the Canadian Institutes of Health Research
   (CIHR grant number 311143), the Fonds de Recherche du Quebec - Sante,
   and the Department of Family Medicine and Emergency medicine, Universite
   de Sherbrooke. The Authors have declared that there are no conflict of
   interests in relation to the subject of this study.
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NR 38
TC 50
Z9 56
U1 0
U2 14
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0001-690X
EI 1600-0447
J9 ACTA PSYCHIAT SCAND
JI Acta Psychiatr. Scand.
PD NOV
PY 2016
VL 134
IS 5
BP 374
EP 384
DI 10.1111/acps.12621
PG 11
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA EC1GB
UT WOS:000387851800002
PM 27404582
DA 2025-06-11
ER

PT J
AU Lee, HY
   Lee, GH
   Yoon, Y
   Chae, HJ
AF Lee, Hwa-Young
   Lee, Geum-Hwa
   Yoon, Young
   Chae, Han-Jung
TI Rhus verniciflua and Eucommia ulmoides Protects
   Against High-Fat Diet-Induced Hepatic Steatosis by Enhancing
   Anti-Oxidation and AMPK Activation
SO AMERICAN JOURNAL OF CHINESE MEDICINE
LA English
DT Article
DE Oxidative Stress; ER Stress; AMPK; Anti-oxidant; Reactive Oxygen Species
ID ENDOPLASMIC-RETICULUM STRESS; LIVER-DISEASE; OXIDATIVE STRESS;
   LIPID-ACCUMULATION; STOKES EXTRACT; SUPPRESSION; DIAGNOSIS; OBESITY
AB Nonalcoholic fatty liver disease (NAFLD) is a chronic liver disorder associated with features of metabolic syndrome and oxidative stress. We examined the mechanism by which the combined extracts of Rhus verniciflua and Eucommia ulmoides extracts (ILF-RE) regulate hepatic dyslipidemia in an established NAFLD model, high-fat diet (HFD)-induced lipid dysmetabolism in rats. ILF-RE attenuated alanine aminotransferase (ALT) by 1.5% (p < 0.05), aspartate aminotransferase (AST) by 1.5% (p < 0.05), triglycerides by 1.5% (p < 0.05), cholesterol by 2.0% (p < 0.05), and lipid peroxidation by 1.5% (p < 0.05) in the NAFLD model. ILF-RE, recently shown to have anti-oxidant properties, also inhibited hepatic ROS accumulation by 1.68% (p < 0.05) and regulated ER-redox imbalance, a key phenomenon of ER stress. Due to nutrient overload stress-associated protein folding, ER stress and downstream SREBP-lipogenic transcription signaling were highly activated, and the mTORC1-AMPK axis was also disturbed, leading to hepatic steatosis. ILF-RE results in recovery from hepatic conditions induced by nutrient-based protein folding stress signaling and the ER stress-SREBP and AMPK-mTORC1-SREBP1 axes. Based on these results, ILF-RE is suggested to be a potential therapeutic strategy for hepatic steatosis and may represent a promising novel agent for the prevention and treatment of NAFLD.
C1 [Lee, Hwa-Young] Chonbuk Natl Univ Hosp, Dept Pharmacol, Jeonju 561180, Chonbuk, South Korea.
   [Lee, Hwa-Young] Chonbuk Natl Univ Hosp, New Drug Dev Inst, Jeonju 561180, Chonbuk, South Korea.
   [Lee, Geum-Hwa; Chae, Han-Jung] Chonbuk Natl Univ Hosp, Nonclin Evaluat Ctr, Biomed Res Inst, Jeonju 561180, Chonbuk, South Korea.
   [Yoon, Young] Imsil Cheese & Food Res Inst, Doin 2 Gil, Imsil Gun 55918, Chonbuk, South Korea.
C3 Jeonbuk National University; Jeonbuk National University Hospital;
   Jeonbuk National University; Jeonbuk National University Hospital;
   Jeonbuk National University; Jeonbuk National University Hospital
RP Chae, HJ (corresponding author), Chonbuk Natl Univ Hosp, Dept Pharmacol, Jeonju 561180, Chonbuk, South Korea.; Chae, HJ (corresponding author), Chonbuk Natl Univ Hosp, New Drug Dev Inst, Jeonju 561180, Chonbuk, South Korea.; Chae, HJ (corresponding author), Chonbuk Natl Univ Hosp, Nonclin Evaluat Ctr, Biomed Res Inst, Jeonju 561180, Chonbuk, South Korea.
EM hjchae@chonbuk.ac.kr
FU Local Strategic Food Industry Development Project
FX This work was supported by the Local Strategic Food Industry Development
   Project.
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NR 34
TC 7
Z9 8
U1 2
U2 17
PU WORLD SCIENTIFIC PUBL CO PTE LTD
PI SINGAPORE
PA 5 TOH TUCK LINK, SINGAPORE 596224, SINGAPORE
SN 0192-415X
EI 1793-6853
J9 AM J CHINESE MED
JI Am. J. Chin. Med.
PY 2019
VL 47
IS 6
BP 1253
EP 1270
DI 10.1142/S0192415X19500642
PG 18
WC Integrative & Complementary Medicine; Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine; General & Internal Medicine
GA IZ6WM
UT WOS:000487225600004
PM 31488034
DA 2025-06-11
ER

PT J
AU Isa, ZM
   Amsah, N
   Ahmad, N
AF Md Isa, Zaleha
   Amsah, Norizzati
   Ahmad, Norfazilah
TI The Impact of Vitamin D Deficiency and Insufficiency on the Outcome of
   Type 2 Diabetes Mellitus Patients: A Systematic Review
SO NUTRIENTS
LA English
DT Review
DE impact; implication; vitamin D deficiency; vitamin D insufficiency;
   diabetes mellitus; hyperglycaemia
ID SERUM 25-HYDROXYVITAMIN D; QUALITY-OF-LIFE; GLYCEMIC CONTROL;
   INSULIN-RESISTANCE; D SUPPLEMENTATION; D LEVEL; ASSOCIATION;
   COMPLICATIONS; NEPHROPATHY; PREVALENCE
AB Vitamin D deficiency and insufficiency are public health concerns that have contributed to multiple negative health outcomes. Recent studies have revealed that vitamin D deficiency and insufficiency influence glycaemic control and the development of diabetes complications. The goal of this systematic review is to summarise the latest evidence on the impact of vitamin D deficiency and insufficiency on the outcome of Type 2 Diabetes Mellitus (T2DM) patients. In this PRISMA-guided systematic review, articles were sourced from three databases, namely, PubMed, Scopus, and Web of Science. The review only included literature published from 2012 until 2022, and 33 eligible studies met the inclusion criteria for this review. The included articles were critically appraised using the Mixed Method Appraisal Tool (MMAT). According to our findings, vitamin D deficiency or insufficiency is associated with mental health status, macrovascular and microvascular complications of T2DM, metabolic syndrome, increased risk of obesity, increased blood pressure, dyslipidaemia, glycaemic control, nerve-related disease, musculoskeletal-related complications, and reduced quality of life. Due to the diverse implications of vitamin D deficiency and insufficiency, screening for vitamin D levels in T2DM patients may be beneficial.
C1 [Md Isa, Zaleha; Amsah, Norizzati; Ahmad, Norfazilah] Univ Kebangsaan Malaysia, Fac Med, Dept Publ Hlth Med, Jalan Yaacob Latif, Kuala Lumpur 56000, Malaysia.
C3 Universiti Kebangsaan Malaysia
RP Ahmad, N (corresponding author), Univ Kebangsaan Malaysia, Fac Med, Dept Publ Hlth Med, Jalan Yaacob Latif, Kuala Lumpur 56000, Malaysia.
EM norfazilah@ppukm.ukm.edu.my
RI Amsah, Norizzati/AFT-0052-2022; Isa, Zaleha/AAJ-9654-2020
OI Amsah, Norizzati/0000-0003-2531-5159; Ahmad, Dr.
   Norfazilah/0000-0003-4964-8652
FU Universiti Kebangsaan Malaysia (UKM) [FF-2022-252]
FX The authors would like to thank Universiti Kebangsaan Malaysia (UKM) for
   funding this study under the Faculty of Medicine Fundamental Grant
   (FF-2022-252).
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NR 95
TC 14
Z9 14
U1 2
U2 11
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD MAY 15
PY 2023
VL 15
IS 10
AR 2310
DI 10.3390/nu15102310
PG 16
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA H5UC7
UT WOS:000996602500001
PM 37242192
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Lykouras, L
   Douzenis, A
AF Lykouras, Lefteris
   Douzenis, Athanasios
TI Do psychiatric departments in general hospitals have an impact on the
   physical health of mental patients?
SO CURRENT OPINION IN PSYCHIATRY
LA English
DT Article
DE physical comorbidity; serious mental illness
ID CORONARY-HEART-DISEASE; METABOLIC SYNDROME; EXCESS MORTALITY;
   SCHIZOPHRENIA; PEOPLE; ILLNESS; RISK; PREVENTION; DISORDERS; CANCER
AB Purpose of review
   Recent literature has increased awareness of the physical health problems that affect mental-health patients. The close association of psychiatric departments with other medical departments can lead to improved communication and support between all medical specialties. This review assesses the impact these developments have on the physical health of individuals with psychiatric disorders.
   Recent findings
   The current literature shows that mentally ill individuals have increased physical illness comorbidity. They do not regularly attend screening programmes or follow-up appointments. They also have an increased incidence of unwanted events while hospitalized. These disturbing findings cannot be wholly explained by lifestyle factors and antipsychotic medication and it seems that stigma against mental illness has an effect as well.
   Summary
   No evidence has emerged that the medical screening of psychiatric patients has improved overall. Psychiatrists may be coming more sensitive to the fact that their patients need close monitoring, not only of their mental state but also their blood pressure, sugar glucose and weight. Sensitizing clinicians to the needs of psychiatric patients is a slow procedure. There is a great need for studies on specific interventions aimed at specific medical conditions that coexist more frequently with psychiatric disorders.
C1 [Lykouras, Lefteris; Douzenis, Athanasios] Univ Athens, Sch Med, Dept Psychiat 2, Attikon Hosp, GR-11527 Athens, Greece.
C3 National & Kapodistrian University of Athens; University Hospital
   Attikon; Athens Medical School
RP Lykouras, L (corresponding author), Univ Athens, Sch Med, Dept Psychiat 2, Attikon Hosp, GR-11527 Athens, Greece.
EM panpsyclin@attikonhospital.gr
RI Douzenis, Athanasios/AGG-3433-2022
OI , Douzenis/0000-0002-5321-7276
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NR 32
TC 18
Z9 20
U1 0
U2 7
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0951-7367
EI 1473-6578
J9 CURR OPIN PSYCHIATR
JI Curr. Opin. Psychiatr.
PD JUL
PY 2008
VL 21
IS 4
BP 398
EP 402
DI 10.1097/YCO.0b013e32830079d0
PG 5
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 318ZB
UT WOS:000257130200018
PM 18520746
DA 2025-06-11
ER

PT J
AU Mohseni, R
   Teimouri, M
   Safaei, M
   Sadeghabadi, ZA
AF Mohseni, Roohollah
   Teimouri, Maryam
   Safaei, Mohsen
   Sadeghabadi, Zahra Arab
TI AMP-activated protein kinase is a key regulator of obesity-associated
   factors
SO CELL BIOCHEMISTRY AND FUNCTION
LA English
DT Review
DE AMP-activated protein kinases; inflammation; obesity; oxidative stress;
   silent information regulators
ID NF-KAPPA-B; ANGIOPOIETIN-LIKE PROTEINS; INSULIN-RESISTANCE; OXIDATIVE
   STRESS; GHRELIN LEVELS; CHICORIC ACID; FOOD-INTAKE; INFLAMMATION;
   EXPRESSION; VISFATIN
AB An imbalance between caloric intake and energy expenditure leads to obesity. Obesity is an important risk factor for the development of several metabolic diseases including insulin resistance, metabolic syndrome, type 2 diabetes mellitus, and cardiovascular disease. So, controlling obesity could be effective in the improvement of obesity-related diseases. Various factors are involved in obesity, such as AMP-activated protein kinases (AMPK), silent information regulators, inflammatory mediators, oxidative stress parameters, gastrointestinal hormones, adipokines, angiopoietin-like proteins, and microRNAs. These factors play an important role in obesity by controlling fat metabolism, energy homeostasis, food intake, and insulin sensitivity. AMPK is a heterotrimeric serine/threonine protein kinase known as a fuel-sensing enzyme. The central role of AMPK in obesity makes it an attractive molecule to target obesity and related metabolic diseases. In this review, the critical role of AMPK in obesity and the interplay between AMPK and obesity-associated factors were elaborated.
C1 [Mohseni, Roohollah; Sadeghabadi, Zahra Arab] Shahrekord Univ Med Sci, Basic Hlth Sci Inst, Clin Biochem Res Ctr, Shahrekord, Iran.
   [Mohseni, Roohollah; Sadeghabadi, Zahra Arab] Shahrekord Univ Med Sci, Sch Med, Dept Clin Biochem & Nutr, Shahrekord, Iran.
   [Teimouri, Maryam] Shahroud Univ Med Sci, Sch Allied Med Sci, Dept Biochem, Shahroud, Iran.
   [Safaei, Mohsen] Shahrekord Univ Med Sci, Sch Adv Technol, Dept Med Biotechnol, Shahrekord, Iran.
C3 Shahrekord University Medical Sciences; Shahrekord University Medical
   Sciences; Shahroud University Medical Sciences; Shahrekord University
   Medical Sciences
RP Sadeghabadi, ZA (corresponding author), Shahrekord Univ Med Sci, Basic Hlth Sci Inst, Clin Biochem Res Ctr, Shahrekord, Iran.
EM zahra.arab125@yahoo.com
RI Mohseni, Rooholla/AAX-2500-2020; teimouri, maryam/AAO-9967-2021
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NR 99
TC 16
Z9 16
U1 2
U2 18
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0263-6484
EI 1099-0844
J9 CELL BIOCHEM FUNCT
JI Cell Biochem. Funct.
PD JAN
PY 2023
VL 41
IS 1
BP 20
EP 32
DI 10.1002/cbf.3767
EA DEC 2022
PG 13
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA FB2W4
UT WOS:000897591400001
PM 36468539
DA 2025-06-11
ER

PT J
AU Barbaresco, GQ
   Reis, AVP
   Lopes, GD
   Boaventura, LP
   Castro, AF
   Vilanova, TCF
   Da Cunha, EC
   Pires, KC
   Pôrto, R
   Pereira, BB
AF Barbaresco, Geovana Queiroz
   Pires Reis, Anelise Vitoria
   Lopes, Gabriella Da Rocha
   Boaventura, Leticia Pereira
   Castro, Amanda Freitas
   Ferreira Vilanova, Tereza Cristina
   Da Cunha Junior, Ezequias Cardozo
   Pires, Kyllian Cesar
   Porto Filho, Roberto
   Pereira, Boscolli Barbosa
TI Effects of environmental noise pollution on perceived stress and
   cortisol levels in street vendors
SO JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES
LA English
DT Article
DE Toxicology; stress; biomarkers; environmental health; public health
ID AIR-POLLUTION; METABOLIC SYNDROME; SALIVA CORTISOL; ASSOCIATION;
   EXPOSURE; OBESITY
AB The present study describes and analyzes experimental results of a study performed with street vendors exposed to noise pollution by monitoring daily variations in cortisol levels taking into account the influence of variables such as age and body mass index (BMI). The study was conducted with 17 male street vendors, inhabitants of Uberlandia - Brazil, who work in the central region of the city. The levels of exposure to noise were assessed using an audio dosimeter and, every two hr, samples of saliva were collected for determination of salivary cortisol levels through an enzymatic immunoassay. The measured equivalent A-weighted sound level (LAeq) ranged from 70.2 to 76.6 dB (A) during the monitoring period of endogenous salivary cortisol levels. Morning levels of cortisol in street vendors were higher in older and overweight individuals. The noise levels to which the subjects were exposed were above the acoustic comfort threshold established by the World Health Organization and hence may be associated with severe discomfort and stress
C1 [Barbaresco, Geovana Queiroz; Pires Reis, Anelise Vitoria; Lopes, Gabriella Da Rocha; Boaventura, Leticia Pereira; Castro, Amanda Freitas; Ferreira Vilanova, Tereza Cristina; Pires, Kyllian Cesar; Porto Filho, Roberto; Pereira, Boscolli Barbosa] Univ Fed Uberlandia, Inst Geog, Dept Environm Hlth, Santa Monica Campus,Ave Joao Naves de Avila 2121, BR-38408100 Uberlandia, MG, Brazil.
   [Da Cunha Junior, Ezequias Cardozo] Univ Fed Uberlandia, Inst Biol, Uberlandia, MG, Brazil.
C3 Universidade Federal de Uberlandia; Universidade Federal de Uberlandia
RP Pereira, BB (corresponding author), Univ Fed Uberlandia, Inst Geog, Dept Environm Hlth, Santa Monica Campus,Ave Joao Naves de Avila 2121, BR-38408100 Uberlandia, MG, Brazil.
EM boscolli86@hotmail.com
RI Pires, Kelly/M-8757-2014; da Cunha Junior, Ezequias/B-4311-2019;
   Pereira, Boscolli/LRS-7712-2024
OI Pereira, Boscolli/0000-0002-2633-9067; Reis,
   AlessanRSS/0000-0001-8486-7469
FU "Conselho Nacional de Desenvolvimento Cientifico e Tecnologico" (CNPq)
FX Financial support is acknowledged to "Conselho Nacional de
   Desenvolvimento Cientifico e Tecnologico" (CNPq).
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NR 33
TC 24
Z9 26
U1 1
U2 37
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1528-7394
EI 1087-2620
J9 J TOXICOL ENV HEAL A
JI J. Toxicol. Env. Health Part A
PD MAR 4
PY 2019
VL 82
IS 5
BP 331
EP 337
DI 10.1080/15287394.2019.1595239
EA MAR 2019
PG 7
WC Environmental Sciences; Public, Environmental & Occupational Health;
   Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health; Toxicology
GA HY4EX
UT WOS:000464379200001
PM 30915910
DA 2025-06-11
ER

PT J
AU Brahmi, N
   Saoudi, M
   Kadri, Y
   Kallel, C
   El Euch, A
   Ayadi, FM
   Harrath, AH
   El Feki, A
   Allagui, MS
AF Brahmi, Noura
   Saoudi, Mongi
   Kadri, Yamina
   Kallel, Chomous
   El Euch, Aida
   Ayadi, Fatma Makni
   Harrath, Abdel Halim
   El Feki, Abdelfatah
   Allagui, Mohamed Salah
TI Protective effect of Chaetomorpha gracilis aqueous extract
   against erythrocytes oxidative damage induced by high fat diet in
   treated mice
SO ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
LA English
DT Article
DE Erythrocytes; high fat diet; oxidative stress; Chaetomorpha gracilis
ID METABOLIC SYNDROME; ANTIOXIDANT; STRESS; LIVER; SELENIUM; OBESITY; ACID;
   RATS; SEED
AB High fat diet (HFD) exposure is associated with various pathological dysfunctions, including haematological disorders and oxidative stress. The in vitro analysis of AECG revealed the presence of important levels of polyphenols and flavonoids, and denoted antioxidant capacities confirmed by nitric oxide radical (NO center dot), reducing the power and HPLC chemical components' determinations. The animals exposed to HFD revealed a severe damage in the blood cells structure and haematological parameters accompanied with a significant decrease in serum Mg2+ and Ca2+ ATPase activities. Furthermore, malondialdehyde (MDA) and the advanced oxidation of protein products (AOPP) levels were significantly increased, while vitamin C level, superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities were markedly reduced in the erythrocytes and platelets of HFD-treated mice. However, the co-administration of AECG with HFD-treated animals restored the parameters cited above to near-normal values. Therefore, our investigation revealed that Chaetomorpha gracilis extract was a useful element preventing HFD-induced blood cells damage.
C1 [Brahmi, Noura; Saoudi, Mongi; Kadri, Yamina; El Feki, Abdelfatah; Allagui, Mohamed Salah] Univ Sfax, Sfax Fac Sci, Lab Anim Physiol, Sfax, Tunisia.
   [Kallel, Chomous] Univ Sfax, Hematol Lab, CHU Habibbourguibaof Sfax, Sfax, Tunisia.
   [El Euch, Aida; Ayadi, Fatma Makni] CHU Habib Bourguiba Sfax, Biochem Lab, Sfax, Tunisia.
   [Harrath, Abdel Halim] King Saud Univ, Zool Dept, Coll Sci, Riyadh, Saudi Arabia.
C3 Universite de Sfax; Faculty of Sciences Sfax; Universite de Sfax;
   Universite de Sfax; Ecole Nationale dIngenieurs de Sfax (ENIS); Hopital
   Habib Bourguiba; King Saud University
RP Saoudi, M (corresponding author), Sfax Fac Sci, Dept Life Sci, BP 1171, Sfax 3000, Tunisia.
EM mongifss@yahoo.fr
RI elfeki, abdelfattah/LKL-6561-2024; Harrath, Abdel Halim/K-2166-2014
OI Harrath, Abdel Halim/0000-0002-2170-1303; elfeki,
   abdelfattah/0009-0009-9949-1367; Saoudi, Mongi/0000-0001-6535-6823
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NR 36
TC 7
Z9 7
U1 0
U2 9
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1381-3455
EI 1744-4160
J9 ARCH PHYSIOL BIOCHEM
JI Arch. Physiol. Biochem.
PD MAY 27
PY 2019
VL 125
IS 3
BP 220
EP 227
DI 10.1080/13813455.2018.1448997
PG 8
WC Biochemistry & Molecular Biology; Biophysics; Endocrinology &
   Metabolism; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Endocrinology &
   Metabolism; Physiology
GA HX9LK
UT WOS:000467729000004
PM 29544357
DA 2025-06-11
ER

PT J
AU Cüce, F
   Demiray, Ö
   Küçük, U
   Olgun Küçük, H
AF Cuce, Ferhat
   Demiray, Ozay
   Kucuk, Ugur
   Olgun Kucuk, Hilal
TI Varicocele: tissue stress in the etiology
SO TURKISH JOURNAL OF MEDICAL SCIENCES
LA English
DT Article
DE RDW; MPV; varicocele; infertility; BMI
ID CELL DISTRIBUTION WIDTH; CORONARY-ARTERY ECTASIA; MEAN PLATELET VOLUME;
   BODY-MASS INDEX; OXIDATIVE STRESS; METABOLIC SYNDROME; ASSOCIATION;
   MORTALITY; PROTEIN; DISEASE
AB Background/aim: It is accepted that red blood cell distribution width (RDW) is a novel prognostic marker that reflects oxidative stress and chronic inflammation. In this study, we aimed to investigate the correlation between RDW and varicocele, the etiology of which has not fully elucidated yet. This study also aimed to study the mean platelet volume (MPV) values of the patient and control group.
   Materials and methods: RDW and MPV levels were measured in 50 varicocele subjects (group 1) and 48 healthy controls (group 2) from January 2012 to January 2014, retrospectively.
   Results: MPV levels were significantly higher in group 1 than in group 2 (P < 0.001). Although the relationship was weak, the patients with varicocele had significantly lower RDW values than did the controls (r: 0.24 P = 0.026). Positive correlations were not found between varicocele grade and MPV and RDW values (P < 0.05)
   Conclusion: Higher MPV values are associated with increased odds of developing varicocele.
C1 [Cuce, Ferhat] Van Mil Hosp, Dept Radiol, Van, Turkey.
   [Demiray, Ozay] Van Mil Hosp, Dept Urol, Van, Turkey.
   [Kucuk, Ugur] Van Mil Hosp, Dept Cardiol, Van, Turkey.
   [Olgun Kucuk, Hilal] Van Educ & Res Hosp, Dept Cardiol, Van, Turkey.
C3 Van Training & Research Hospital; Van Training & Research Hospital;
   Yuzuncu Yil University; Van Training & Research Hospital; Van Training &
   Research Hospital; Yuzuncu Yil University
RP Cüce, F (corresponding author), Van Mil Hosp, Dept Radiol, Van, Turkey.
EM ferhatcuce@hotmail.com
RI Cuce, Ferhat/AAY-4703-2021
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NR 24
TC 6
Z9 6
U1 0
U2 4
PU Tubitak Scientific & Technological Research Council Turkey
PI ANKARA
PA ATATURK BULVARI NO 221, KAVAKLIDERE, TR-06100 ANKARA, TURKIYE
SN 1300-0144
EI 1303-6165
J9 TURK J MED SCI
JI Turk. J. Med. Sci.
PY 2016
VL 46
IS 4
BP 1014
EP 1017
DI 10.3906/sag-1411-70
PG 4
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA DP6YT
UT WOS:000378646700011
PM 27513398
OA Bronze
DA 2025-06-11
ER

PT J
AU Garbarino, S
   Magnavita, N
AF Garbarino, Sergio
   Magnavita, Nicola
TI Sleep problems are a strong predictor of stress-related metabolic
   changes in police officers. A prospective study
SO PLOS ONE
LA English
DT Article
ID JOB STRESS; PSYCHOSOCIAL STRESS; SHIFT WORK; PSYCHOMETRIC PROPERTIES;
   DECISION LATITUDE; QUALITY INDEX; RISK-FACTORS; POOR SLEEP; DURATION;
   SUPPORT
AB Objective
   Previous studies have shown that workers chronically exposed to occupational stress have an increased risk of metabolic syndrome (MetS) and sleep problems (SPs). The purpose of this study was to verify whether SPs mediate the relationship between stress and MetS.
   Method
   A 5-year prospective cohort study included 242 police officers from a rapid response unit engaged exclusively in maintaining law and order. Perceived stress levels were measured repeatedly with the demand-control-support and the effort-reward-imbalance questionnaires; insomnia symptoms were assessed with the Pittsburgh Sleep Quality Index; excessive daytime sleepiness was measured using the Epworth Sleepiness Scale. MetS and its components were evaluated at baseline and at follow-up.
   Results
   During 5-year follow-up period, 26 new cases of MetS were identified. Both occupational stress and SPs were significantly related to incident cases of MetS. Insomnia symptoms showed a highly significant association with MetS (aOR 11.038; C195% 2.867-42.493). Mediation analysis confirmed that SPs mediate the relationship between stress and MetS.
   A reciprocal relationship was found between job stress and SPs. Work-related stress was a significant predictor of insomnia symptoms, short sleep duration, sleep dissatisfaction, and sleepiness. Compared to the reference group, police officers with SPs at baseline had significantly higher odds of reporting high stress at follow-up.
   Conclusion
   SPs play a mediating role in the relationship between occupational stress and MetS. Prevention of MetS must include the control of stress factors and an increase in the resilience of workers, but correct sleep hygiene is also an essential factor.
C1 [Garbarino, Sergio; Magnavita, Nicola] Univ Cattolica Sacro Cuore, Postgrad Sch Occupat Hlth, Rome, Italy.
   [Garbarino, Sergio] Minist Interior, State Police Hlth Serv Dept, Rome, Italy.
   [Garbarino, Sergio] Dept Neurosci Rehabil Ophthalmol Genet & Maternal, Genoa, Italy.
   [Magnavita, Nicola] Fdn Policlin Gemelli IRCCS, Dept Woman Child & Publ Hlth, Rome, Italy.
C3 Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli;
   Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli
RP Magnavita, N (corresponding author), Univ Cattolica Sacro Cuore, Postgrad Sch Occupat Hlth, Rome, Italy.; Magnavita, N (corresponding author), Fdn Policlin Gemelli IRCCS, Dept Woman Child & Publ Hlth, Rome, Italy.
EM nicolamagnavita@gmail.com
RI Magnavita, Nicola/J-6074-2014; Garbarino, Sergio/X-5368-2018
OI Garbarino, Sergio/0000-0002-8508-552X
FU Universita Cattolica del Sacro Cuore of Rome
FX The Universita Cattolica del Sacro Cuore of Rome contributed to the
   funding of this research project and its publication. The funders had no
   role in study design, data collection and analysis, decision to publish,
   or preparation of the manuscript.The Universita Cattolica del Sacro
   Cuore of Rome contributed to the funding of this research project and
   its publication. The funders had no role in study design, data
   collection and analysis, decision to publish, or preparation of the
   manuscript.
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NR 87
TC 55
Z9 67
U1 0
U2 8
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD OCT 22
PY 2019
VL 14
IS 10
AR e0224259
DI 10.1371/journal.pone.0224259
PG 19
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Science & Technology - Other Topics
GA LM9ME
UT WOS:000532571400043
PM 31639178
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Wessel, J
   Moratorio, G
   Rao, F
   Mahata, M
   Zhang, L
   Greene, W
   Rana, BK
   Kennedy, BP
   Khandrika, S
   Huang, P
   Lillie, EO
   Shih, PAB
   Smith, DW
   Wen, G
   Hamilton, BA
   Ziegler, MG
   Witztum, JL
   Schork, NJ
   Schmid-Schonbein, GW
   O'Connor, DT
AF Wessel, Jennifer
   Moratorio, Guillermo
   Rao, Fangwen
   Mahata, Manjula
   Zhang, Lian
   Greene, William
   Rana, Brinda K.
   Kennedy, Brian P.
   Khandrika, Srikrishna
   Huang, Pauline
   Lillie, Elizabeth O.
   Shih, Pei-An Betty
   Smith, Douglas W.
   Wen, Gen
   Hamilton, Bruce A.
   Ziegler, Michael G.
   Witztum, Joseph L.
   Schork, Nicholas J.
   Schmid-Schonbein, Geert W.
   O'Connor, Daniel T.
TI C-reactive protein, an 'intermediate phenotype' for inflammation:: human
   twin studies reveal heritability, association with blood pressure and
   the metabolic syndrome, and the influence of common polymorphism at
   catecholaminergic/β-adrenergic pathway loci
SO JOURNAL OF HYPERTENSION
LA English
DT Article
DE adrenergic; catecholamine; hypertension; inflammation; metabolic;
   receptor; tyrosine hydroxylase
ID SYMPATHETIC-NERVOUS-SYSTEM; CORONARY-HEART-DISEASE; SPONTANEOUSLY
   HYPERTENSIVE-RATS; HYDROGEN-PEROXIDE PRODUCTION; TRAIT LINKAGE ANALYSIS;
   CARDIOVASCULAR-DISEASE; OXIDATIVE STRESS; RECEPTOR GENE; RISK-FACTORS;
   TYROSINE-HYDROXYLASE
AB Background C-reactive protein (CRP) both reflects and participates in inflammation, and its circulating concentration marks cardiovascular risk. Here we sought to understand the role of heredity in determining CRP secretion.
   Methods CRP, as well as multiple facets of the metabolic syndrome, were measured in a series of 229 twins, both monozygotic (MZ) and dizygotic (DZ), to estimate trait heritability (h 2). Single nucleoticle polymorphism (SNP) genotyping was done at adrenergic pathway loci. Haplotypes were inferred from genotypes by likelihood methods. Association of CRP with hypertension and the metabolic syndrome was studied in a larger series of 732 individuals, including 79 with hypertension.
   Results MZ and DZ twin variance components indicated substantial h(2) for CRP, at similar to 56 +/- 7% (P < 0.001). CRP was significantly associated (P < 0.05) with multiple features of the metabolic syndrome in twins, including body mass index (BMI), blood pressure (BP), leptin and lipids. In established hypertension, elevated CRP was associated with increased BP, BMI, insulin, HOMA (index of insulin resistance), leptin, triglycerides and norepinephrine. Twin correlations indicated pleiotropy (shared genetic determination) for CRP with BMI (P=0.0002), leptin (P < 0.001), triglycerides (P=0.002) and systolic blood pressure (SBP) (P=0.042). Approximately 9800 genotypes (43 genetic variants at 17 loci) were scored within catecholaminergic pathways: biosynthetic, receptor and signal transduction. Plasma CRP concentration in twins was predicted by polymorphisms at three loci in physiological series within the catecholamine biosynthetic/beta-adrenergic pathway: TH (tyrosine hydroxylase), ADRB1 (beta(1)-adrenergic receptor) and ADRB2 (beta(2)-adrenergic receptor). In the TH promoter, common allelic variation accounted for up to similar to 6.6% of CRP inter-individual variance. At ADRB1, variation at Gly389Arg predicted similar to 2.8% of CRP, while ADRB2 promoter variants T-47C and T-20C also contributed. Particular haplotypes and diplotypes at TH and ADRB1 also predicted CRP, though typically no better than single SNPs alone. Epistasis (gene-by-gene interaction) was demonstrated for particular combinations of TH and ADRB2 alleles, consistent with their actions in a pathway in series. In an illustration of pleiotropy, not only CRP but also plasma triglycericles were predicted by polymorphisms at TH (P=0.0053) and ADRB2 (P=0.027).
   Conclusions CRP secretion is substantially heritable in humans, demonstrating pleiotropy (shared genetic determination) with other features of the metabolic syndrome, such as BMI, triglycerides or BP. Multiple, common genetic variants in the catecholaminergic/beta-adrenergic pathway contribute to CRP, and these variants (especially at TH and ADRB2) seem to interact (epistasis) to influence the trait. The results uncover novel pathophysiological links between the adrenergic system and inflammation, and suggest new strategies to probe the role and actions of inflammation within this setting. J Hypertens 25:329-343 (c) 2007 Lippincott Williams & Wilkins.
C1 Univ Calif San Diego, Dept Bioengn, La Jolla, CA 92093 USA.
   Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA.
   Univ Calif San Diego, Dept Biol, La Jolla, CA 92093 USA.
   Univ Calif San Diego, Dept Pharmacol, La Jolla, CA 92093 USA.
   Univ Calif San Diego, Polymorphism Res Lab, La Jolla, CA 92093 USA.
   Univ Calif San Diego, Ctr Human Genet & Genomics, La Jolla, CA 92093 USA.
   VA San Diego Healthcare Syst, San Diego, CA USA.
C3 University of California System; University of California San Diego;
   University of California System; University of California San Diego;
   University of California System; University of California San Diego;
   University of California System; University of California San Diego;
   University of California System; University of California San Diego;
   University of California System; University of California San Diego; US
   Department of Veterans Affairs; Veterans Health Administration (VHA); VA
   San Diego Healthcare System
RP Schmid-Schonbein, GW (corresponding author), Univ Calif San Diego, Sch Med, Dept Med 0838, 9500 Gilman Dr, La Jolla, CA 92093 USA.
EM gschmid@ucsd.edu; doconnor@ucsd.edu
RI 文, 根/JWP-9726-2024; Ziegler, Michael/L-4728-2019; Shih, Pei-an
   (Betty)/M-9504-2016
OI Shih, Pei-an (Betty)/0000-0001-5318-6476; Wessel,
   Jennifer/0000-0002-7031-0085; Schork, Nicholas/0000-0003-0920-5013
FU NCRR NIH HHS [RR00827] Funding Source: Medline; NHLBI NIH HHS [P01
   HL058120] Funding Source: Medline
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NR 73
TC 91
Z9 98
U1 0
U2 12
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0263-6352
EI 1473-5598
J9 J HYPERTENS
JI J. Hypertens.
PD FEB
PY 2007
VL 25
IS 2
BP 329
EP 343
DI 10.1097/HJH.0b013e328011753e
PG 15
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 130ZD
UT WOS:000243836600013
PM 17211240
DA 2025-06-11
ER

PT J
AU Mitsuhashi, T
AF Mitsuhashi, Toshiharu
TI Heterogeneity of the effect of the COVID-19 pandemic on the incidence of
   Metabolic Syndrome onset at a Japanese campus
SO PEERJ
LA English
DT Article
DE COVID-19; Metabolic syndrome; Healch check up; Conditional average
   treatment effect; CATE; Public health; Pandemic
ID HEALTH-CARE WORKERS; IMPACT; POPULATION; PREVALENCE
AB Background. The coronavirus disease 2019 (COVID-19) outbreak began in China in December 2019, with the World Health Organization declaring a state of emergency in January 2020. Worldwide implementation of lockdown measures to slow the spread of the virus led to reduced physical activity, disrupted eating habits, mental health issues, and sleep disturbances, which increased the risk of lifestyle -related diseases such as metabolic syndrome (MetS). During the COVID-19 pandemic, healthcare workers, especially intensive care workers, experienced longer working hours and burnout, which further increased the risk of lifestyle -related diseases. Accordingly, it is important to identify individuals at a risk of new -onset MetS during a pandemic, which could direct preventive interventions. This study aimed to assess the heterogeneous impact of the COVID-19 pandemic on the incidence of new -onset MetS based on the conditional average treatment effect (CATE) and to identify at -risk populations. Methods. This study analyzed health checkup data obtained from Okayama University Shikata Campus workers using paired baseline and follow-up years. Baseline data encompassed 2017 to 2019, with respective follow-up data from 2018 to 2020. Furthermore, as the COVID-19 pandemic in Japan began in January 2020, workers who underwent follow-up health checkups in 2018 to 2019 and 2020 were considered as "unexposed"and "exposed,"respectively. As the Shikata campus has several departments, comparisons among departments were made. The primary outcome was new -onset MetS at follow-up. Predictor variables included baseline health checkup results, sex, age, and department (administrative, research, medical, or intensive care department). X -learner was used to calculate the CATE. Results. This study included 3,572 eligible individuals (unexposed, n = 2,181; exposed, n = 1,391). Among them, 1,544 (70.8%) and 866 (62.3%) participants in the unexposed and exposed groups, respectively, were females. The mean age (+/- standard deviation) of the unexposed and exposed groups was 48.2 +/- 8.2 and 47.8 +/- 8.3 years, respectively. The COVID-19 pandemic increased the average probability of new -onset MetS by 4.4% in the overall population. According to the department, the intensive care department showed the highest CATE, with a 15.4% increase. Moreover, there was large heterogeneity according to the department. The high-CATE group was characterized by older age, urinary protein, elevated liver enzymes, higher triglyceride levels, and a history of hyperlipidemia treatment. Conclusions. This study demonstrated that the COVID-19 pandemic increased the incidence of new -onset MetS, with this effect showing heterogeneity at a single Japanese campus. Regarding specific populations, workers in the intensive care department showed an increased risk of new -onset MetS. At -risk populations require specific preventive interventions in case the current COVID-19 pandemic persists or a new pandemic occurs.
C1 [Mitsuhashi, Toshiharu] Okayama Univ Hosp, Ctr Innovat Clin Med, Okayama, Okayama, Japan.
C3 Okayama University
RP Mitsuhashi, T (corresponding author), Okayama Univ Hosp, Ctr Innovat Clin Med, Okayama, Okayama, Japan.
EM mitsuh-t@cc.okayama-u.ac.jp
RI Mitsuhashi, Toshiharu/HSF-6228-2023
FU Occupational Health Promotion Foundation [142]
FX Funding This work was supported by the Occupational Health Promotion
   Foundation (Reiwa-3, No.142) . The funders had no role in study design,
   data collection and analysis, decision to publish, or preparation of the
   manuscript.
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NR 64
TC 1
Z9 1
U1 5
U2 5
PU PEERJ INC
PI LONDON
PA 341-345 OLD ST, THIRD FLR, LONDON, EC1V 9LL, ENGLAND
SN 2167-8359
J9 PEERJ
JI PeerJ
PD APR 5
PY 2024
VL 12
AR e17013
DI 10.7717/peerj.17013
PG 24
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA NV5M7
UT WOS:001203244800004
PM 38590703
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Echeverría, G
   Samith, B
   von Schultzendorf, A
   Pinto, V
   Martínez, X
   Sara, D
   Calzada, M
   Pacheco, J
   Plaza, G
   Scott, F
   Romero, J
   Mateo, C
   Julio, MV
   Utreras-Mendoza, Y
   Binder, MV
   Gutiérrez, F
   Riquelme, ME
   Cuevas, M
   Willatt, R
   Sánchez, O
   Keilendt, A
   Butrón, P
   Jarufe, A
   Huete, I
   Tobar, J
   Martin, S
   Alfaro, V
   Olivos, M
   Pedrals, N
   Bitran, M
   Avalos, I
   Ruini, C
   Ryff, C
   Pérez, D
   Berkowitz, L
   Rigotti, A
AF Echeverria, Guadalupe
   Samith, Barbara
   von Schultzendorf, Andrea
   Pinto, Victoria
   Martinez, Ximena
   Sara, Daniela
   Calzada, Mariana
   Pacheco, Josefina
   Plaza, Gianella
   Scott, Francesca
   Romero, Javiera
   Mateo, Camila
   Julio, Maria Veronica
   Utreras-Mendoza, Yildy
   Binder, Maria Victoria
   Gutierrez, Florencia
   Riquelme, Maria Emilia
   Cuevas, Margarita
   Willatt, Rosario
   Sanchez, Omayra
   Keilendt, Aracelli
   Butron, Patricia
   Jarufe, Alessandra
   Huete, Isidora
   Tobar, Josefina
   Martin, Sofia
   Alfaro, Valentina
   Olivos, Matilde
   Pedrals, Nuria
   Bitran, Marcela
   Avalos, Ivette
   Ruini, Chiara
   Ryff, Carol
   Perez, Druso
   Berkowitz, Loni
   Rigotti, Attilio
TI Mediterranean diet and psychological well-being intervention to reverse
   metabolic syndrome in Chile (CHILEMED trial)
SO CONTEMPORARY CLINICAL TRIALS COMMUNICATIONS
LA English
DT Article
DE Mediterranean diet; Psychological well-being; Metabolic syndrome
ID MENTAL-HEALTH CONTINUUM; SAMPLE-SIZE CALCULATION; POSITIVE PSYCHOLOGY;
   RED WINE; CARDIOVASCULAR-DISEASE; SPANISH TRANSLATION; NEGATIVE AFFECT;
   VALIDATION; METAANALYSIS; STUDENTS
AB Psychosocial status and lifestyle are key risk factors of non-communicable diseases (NCDs), which, in turn, are main drivers of healthcare costs and morbimortality worldwide, including Chile. Mediterranean diet (MedDiet) is one of the healthiest dietary patterns under study. However, its impact on high-risk conditions, such as metabolic syndrome (MetS), and NCDs outside the Mediterranean Basin remains mostly unexplored. Even though Central Chile has an environment, food production, and culinary traditions comparable to those present in Mediterranean countries, few studies-some with significant methodological limitations-have evaluated the effect of MedDiet on health and/or disease in Chilean subjects. Importantly, a Mediterranean lifestyle is a modus vivendi that integrates physical health with mental and social well-being. Psychological well-being (PWB) is associated with healthy behaviors, positive health outcomes, and longevity, thereby emerging as a novel healthcare goal. We report here an ongoing randomized controlled clinical trial in Chilean patients with MetS seeking to test whether (1) a PWB theory-based intervention facilitates induction to and increases long-term adherence to a locally adapted MedDiet, and (2) a MedDiet intervention-implemented alone or combined with well-being promotion-is more effective at reversing MetS compared to individuals following a low-fat diet without psychological support. The CHILEan MEDiterranean (CHILEMED) diet intervention study is a 1-year trial including patients with MetS living in Chile. Participants will be assigned randomly by a computer-generated random number sequence to one of the three intervention arms: a) low-fat diet as control group, b) MedDiet alone, and c) MedDiet plus well-being support. Patients will be followed-up by individual and/or group online nutritional sessions or phone cal as well as 6-and 12-month in-person re-assessment of medical history, medication use, food intake, PWB, anthropometrics/physical exam, and blood collection for laboratory analysis. The primary outcome of the trial will be the effect of the MedDiet-with or without PWB intervention-on overall reversal of MetS compared to low-fat diet alone. Based on a statistical superiority trial, expected impact, and patient loss, the estimated study sample is 339 subjects (113 individuals per arm in 3 equal-sized groups). Currently, we have enrolled 179 patients, predominantly women, evenly distributed by age (group means ranging from 45.7 to 48,9 years-old), 3/4 are obese with almost all of them showing abdominal obesity, 70% are hypertensive, whereas <10% exhibit diabetes. If findings turn out as expected (e.g., MedDiet-with or without PWB intervention-is better than the low-fat diet for reversion of MetS at 1-year follow-up), CHILEMED will provide further beneficial evidence of the MedDiet on NCD risk conditions beyond the Mediterranean region.
C1 [Echeverria, Guadalupe; Samith, Barbara; von Schultzendorf, Andrea; Pinto, Victoria; Martinez, Ximena; Sara, Daniela; Pacheco, Josefina; Plaza, Gianella; Scott, Francesca; Romero, Javiera; Mateo, Camila; Julio, Maria Veronica; Utreras-Mendoza, Yildy; Binder, Maria Victoria; Gutierrez, Florencia; Riquelme, Maria Emilia; Cuevas, Margarita; Willatt, Rosario; Sanchez, Omayra; Keilendt, Aracelli; Butron, Patricia; Jarufe, Alessandra; Huete, Isidora; Tobar, Josefina; Martin, Sofia; Alfaro, Valentina; Olivos, Matilde; Pedrals, Nuria; Bitran, Marcela; Perez, Druso; Berkowitz, Loni; Rigotti, Attilio] Pontificia Univ Catolica, Escuela Med, Ctr Nutr Mol & Enfermedades Cron, Santiago, Chile.
   [Echeverria, Guadalupe; Samith, Barbara; Calzada, Mariana; Pedrals, Nuria; Berkowitz, Loni; Rigotti, Attilio] Pontificia Univ Catolica, Escuela Med, Dept Nutr Diabet & Metab, Diagonal Paraguay 362, 4to Piso, Santiago, Chile.
   [Pinto, Victoria] Pontificia Univ Catolica, Fac Med, Carrera Nutr & Dietet, Ciencias Salud, Santiago, Chile.
   [Avalos, Ivette] Clin Bupa Santiago, Santiago, Chile.
   [Ruini, Chiara] Univ Bologna, Dept Life Qual Studies, Rimini, Italy.
   [Ryff, Carol] Univ Wisconsin, Inst Aging, Madison, WI 53706 USA.
   [Ryff, Carol] Univ Wisconsin, Dept Psychol, Madison, WI 53706 USA.
C3 Pontificia Universidad Catolica de Chile; Pontificia Universidad
   Catolica de Chile; Pontificia Universidad Catolica de Chile; University
   of Bologna; University of Wisconsin System; University of Wisconsin
   Madison; University of Wisconsin System; University of Wisconsin Madison
RP Rigotti, A (corresponding author), Pontificia Univ Catolica, Escuela Med, Dept Nutr Diabet & Metab, Diagonal Paraguay 362, 4to Piso, Santiago, Chile.
EM arigotti@med.puc.cl
RI Berkowitz, Loni/KSF-2029-2024; Echeverría, Guadalupe/GWV-3832-2022;
   Gutierrez, María/AFG-1766-2022; bitran, marcela/AAF-4205-2019; Calzada,
   Mariana/HOC-5725-2023; Ruini, Chiara/AAM-8978-2021
OI Pinto, Victoria/0009-0006-3916-9294; Berkowitz,
   Loni/0000-0002-8562-4845; Calzada, Mariana/0009-0009-2089-9280; RUINI,
   CHIARA/0000-0002-7805-3183
FU grant FONDECYT by Agencia Nacional de Investigacion y Desarrollo (ANID)
   from the Government of Chile [1201607]
FX The ongoing research is funded by grant FONDECYT #1201607 provided by
   Agencia Nacional de Investigacion y Desarrollo (ANID) from the
   Government of Chile. We acknowledge the support of Ambassador Mauro
   Battocchi and his team at the Embassy of Italy in Santiago for
   encouraging promotion of and research on the Mediterranean diet in Chile
   and academic collaborations with Italian academic institutions. Foods
   items delivered to participants were generously provided by Terramater
   (olive oil), COLUN (low-fat milk), and AGROSUPER (poultry and low-fat
   pork meat). Patients have been kindly referred by our colleagues as well
   as SODEXO and Banco Santander in Chile.
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NR 102
TC 0
Z9 0
U1 4
U2 14
PU ELSEVIER INC
PI SAN DIEGO
PA 525 B STREET, STE 1900, SAN DIEGO, CA 92101-4495 USA
EI 2451-8654
J9 CONT CLIN TRIAL COMM
JI Contemp. Clin. Trials Commun.
PD OCT
PY 2023
VL 35
AR 101167
DI 10.1016/j.conctc.2023.101167
EA JUL 2023
PG 9
WC Medicine, Research & Experimental
WE Emerging Sources Citation Index (ESCI)
SC Research & Experimental Medicine
GA P1CY0
UT WOS:001048097900001
PM 37538196
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Zhang, ZQ
   Chen, SC
   Wei, XF
   Xiao, JH
   Huang, DW
AF Zhang, Zongqi
   Chen, Sicong
   Wei, Xunfan
   Xiao, Jinhua
   Huang, Dawei
TI Characterization, Antioxidant Activities, and Pancreatic Lipase
   Inhibitory Effect of Extract From the Edible Insect Polyrhachis
   vicina
SO FRONTIERS IN NUTRITION
LA English
DT Article
DE edible insect; Polyrhachis vicina; hydro-ethanolic extract; antioxidant
   activity; pancreatic lipase
ID PRODUCTS; PLASMA; ACID; FOOD
AB Oxidative stress and obesity are critical risk factors for metabolic syndrome. The consumption of functional food ingredients can a viable strategy to alleviate oxidative stress and obesity. In this study, the hydro-ethanolic extract of the edible insect Polyrhachis vicina was prepared and its bioactive components were characterized. The total polyphenol contents, total flavonoid contents, antioxidant and pancreatic lipase (PL) inhibitory activities of the extract were determined in vitro. In total, 60 bioactive components were tentatively identified in the P. vicina extract. Polyphenols and fatty acids were further quantified using LC-MS and GC-MS, respectively. P. vicina extract possessed excellent antioxidant and PL inhibition activities. Salicylic acid, gallic acid, liquiritigenin, and naringenin, which were the major polyphenols in the P. vicina extract, interacted with PL through hydrogen bonding, hydrophilic or hydrophobic and pi-cation interactions. Thus, P. vicina extract can be used as a nutraceutical to alleviate oxidative stress-induced disease and manage obesity.
C1 [Zhang, Zongqi; Chen, Sicong; Wei, Xunfan; Xiao, Jinhua; Huang, Dawei] Nankai Univ, Coll Life Sci, Tianjin, Peoples R China.
C3 Nankai University
RP Xiao, JH; Huang, DW (corresponding author), Nankai Univ, Coll Life Sci, Tianjin, Peoples R China.
EM xiaojh@nankai.edu.cn; huangdw@ioz.ac.cn
RI Zhang, Zongqi/AAQ-1471-2020
FU National Natural Science Foundation of China [31830084, 31970440];
   construction funds for the "Double First-Class" initiative for Nankai
   University [96172158, 96173250, 91822294]
FX This work was financially supported by the National Natural Science
   Foundation of China (Nos. 31830084 and 31970440), and the construction
   funds for the "Double First-Class" initiative for Nankai University
   (Nos. 96172158, 96173250, and 91822294).
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NR 42
TC 14
Z9 15
U1 5
U2 48
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD APR 7
PY 2022
VL 9
AR 860174
DI 10.3389/fnut.2022.860174
PG 13
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 1D1IX
UT WOS:000793562800001
PM 35464030
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Van De Wier, B
   Koek, GH
   Bast, A
   Haenen, GRMM
AF Van De Wier, Bregje
   Koek, Ger H.
   Bast, Aalt
   Haenen, Guido R. M. M.
TI The potential of flavonoids in the treatment of non-alcoholic fatty
   liver disease
SO CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
LA English
DT Review
DE NAFLD; non-alcoholic steatohepatitis; polyphenols; oxidative stress;
   antioxidants
ID GREEN TEA EXTRACT; NF-KAPPA-B; DIET-INDUCED OBESITY; HEME OXYGENASE 1;
   HEPATIC STEATOSIS; OXIDATIVE STRESS; METABOLIC SYNDROME; RAT MODEL;
   INSULIN-RESISTANCE; LIPID-ACCUMULATION
AB The contemporary pathophysiological model of non-alcoholic fatty liver disease (NAFLD) comprises multiple parallel pathways with a dynamic cross talk that cumulate in steatosis and inflammation, and ultimately fibrosis, cirrhosis, liver failure, and hepatocellular carcinoma. So far, no pharmacological treatment has been approved. A major impediment of drugs, in general, is that they are intended to act on one single target in the pathology of a disease. However, the multitude of pathways involved in the pathogenesis of NAFLD underpins the need for treatments that address these various pathways. Interestingly, flavonoids have been found to have positive effects on lipid metabolism, insulin resistance, inflammation, and oxidative stress, the most important pathophysiological pathways in NAFLD. This puts flavonoids in the spotlight for the treatment of NAFLD and prompted us to review the existing evidence for the use of these food-derived compounds in the treatment of NAFLD.
C1 [Van De Wier, Bregje; Bast, Aalt; Haenen, Guido R. M. M.] Maastricht Univ, Dept Toxicol, POB 616, NL-6200 MD Maastricht, Netherlands.
   [Koek, Ger H.] Maastricht Univ, Div Gastroenterol Hepatol, Dept Internal Med, Med Ctr, Maastricht, Netherlands.
C3 Maastricht University; Maastricht University
RP Van De Wier, B (corresponding author), Maastricht Univ, Dept Toxicol, POB 616, NL-6200 MD Maastricht, Netherlands.
EM b.vandewier@maastrichtuniversity.nl
RI Bast, Aalt/I-7809-2013; Haenen, Guido/H-9209-2013
OI Bast, Aalt/0000-0002-5383-2789; Haenen, Guido/0000-0001-6986-290X
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NR 173
TC 140
Z9 145
U1 3
U2 101
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1040-8398
EI 1549-7852
J9 CRIT REV FOOD SCI
JI Crit. Rev. Food Sci. Nutr.
PY 2017
VL 57
IS 4
BP 834
EP 855
DI 10.1080/10408398.2014.952399
PG 22
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA EF5TU
UT WOS:000390393300013
PM 25897647
OA hybrid
DA 2025-06-11
ER

PT J
AU Saez, F
   Drevet, JR
AF Saez, Fabrice
   Drevet, Joel R.
TI Dietary Cholesterol and Lipid Overload: Impact on Male Fertility
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Review
ID FATTY-ACID-COMPOSITION; WESTERN-STYLE DIET; SEMEN QUALITY; OXIDATIVE
   STRESS; HUMAN-SPERMATOZOA; DOCOSAHEXAENOIC ACIDS; ANTIOXIDANT STATUS;
   METABOLIC SYNDROME; ACROSOME REACTION; SUPEROXIDE ANION
AB Lipid metabolic disorders due to poor eating habits are on the rise in both developed and developing countries, with a negative impact of the "Western diet" on sperm count and quality. Dietary lipid imbalance can involve cholesterol, fatty acids, or both, under different pathophysiological conditions grouped under the term dyslipidemia. The general feature of dyslipidemia is the development of systemic oxidative stress, a well-known deleterious factor for the quality of male gametes and associated with infertility. Sperm are particularly rich in polyunsaturated fatty acids (PUFA), an important characteristic associated with normal sperm physiology and reproductive outcomes, but also targets of choice for oxidative thrust. This review focuses on the effects of dietary cholesterol or different fatty acid overload on sperm composition and function in both animals and humans. The links between oxidative stress induced by dyslipidemia and sperm dysfunction are then discussed, including possible preventive or therapeutic strategies to preserve gamete quality, longevity when stored in cryobanking, and male fertility.
C1 [Saez, Fabrice; Drevet, Joel R.] Univ Clermont Auvergne, INSERM U1103, UMR CNRS 6293, Genet Reprod & Dev GReD Lab, 28 Pl Henri Dunant, F-63000 Clermont Ferrand, France.
C3 Centre National de la Recherche Scientifique (CNRS); Institut National
   de la Sante et de la Recherche Medicale (Inserm); Universite Clermont
   Auvergne (UCA)
RP Saez, F; Drevet, JR (corresponding author), Univ Clermont Auvergne, INSERM U1103, UMR CNRS 6293, Genet Reprod & Dev GReD Lab, 28 Pl Henri Dunant, F-63000 Clermont Ferrand, France.
EM fabrice.saez@uca.fr; joel.drevet@uca.fr
RI Drevet, Joël/W-2692-2019
OI SAEZ, Fabrice/0000-0001-9570-3777; Drevet, Joel/0000-0003-3077-6558
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NR 92
TC 32
Z9 35
U1 1
U2 8
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PD DEC 6
PY 2019
VL 2019
AR 4521786
DI 10.1155/2019/4521786
PG 11
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA JX5NF
UT WOS:000503780800005
PM 31885793
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Otsuka, Y
   Kaneita, Y
   Itani, O
   Nakagome, S
   Jike, M
   Ohida, T
AF Otsuka, Yuichiro
   Kaneita, Yoshitaka
   Itani, Osamu
   Nakagome, Sachi
   Jike, Maki
   Ohida, Takashi
TI Relationship between stress coping and sleep disorders among the general
   Japanese population: a nationwide representative survey
SO SLEEP MEDICINE
LA English
DT Article
DE Stress; Stress coping; Sleep disorder; Epidemiology; Prevalence;
   Japanese
ID PERCEIVED STRESS; ALCOHOL-USE; PSYCHOSOCIAL STRESS; DAYTIME SLEEPINESS;
   PROSPECTIVE COHORT; METABOLIC SYNDROME; CIGARETTE-SMOKING; INSOMNIA
   SYMPTOMS; ALLOSTATIC LOAD; METAANALYSIS
AB Objective: To clarify the prevalence of stress, and examine the relationship between sleep disorders and stress coping strategies among highly stressed individuals in the general Japanese population.
   Methods: A cross-sectional nationwide survey was undertaken in November 2007. Men and women were randomly selected from 300 districts throughout Japan. Data from 7671 (3532 men (average age 53.5 +/- 17.0 years) and 4139 women (average age 53.9 +/- 17.7 years)) were analyzed. Participants completed a self-reported questionnaire on stress, sleep disorders, and stress coping strategies in the previous month.
   Results: Highly stressed individuals comprised 16.6% (95% confidence interval 15.8-17.5%) of the total sample, and most were aged 20-49 years. In multiple logistic regression, symptoms of insomnia (ie, difficulty initiating sleep, difficulty maintaining sleep, and early morning awakening), excessive daytime sleepiness, nightmares, daytime malfunction, and lack of rest due to sleep deprivation were more prone to occur in highly stressed individuals. In addition, logistic regression analysis controlling for other adjustment factors revealed that stress coping strategies such as 'giving up on problem-solving', 'enduring problems patiently', 'smoking' and 'drinking alcohol' were positively associated with the above-mentioned sleep disorders. On the other hand, stress coping strategies such as 'exercising', 'enjoying hobbies', and 'sharing worries' were inversely associated with the above-mentioned sleep disorders.
   Conclusions: Distraction-based stress coping (eg, hobbies, exercise, and optimistic thinking) was found to be preferable to problem-based stress coping in a highly stressed Japanese general population. (C) 2017 Elsevier B.V. All rights reserved.
C1 [Otsuka, Yuichiro; Nakagome, Sachi; Jike, Maki; Ohida, Takashi] Nihon Univ, Sch Med, Dept Social Med, Div Publ Hlth, Tokyo, Japan.
   [Kaneita, Yoshitaka; Itani, Osamu] Oita Univ, Fac Med, Dept Publ Hlth & Epidemiol, Oita, Japan.
C3 Nihon University; Oita University
RP Kaneita, Y (corresponding author), Oita Univ, Fac Med, Dept Publ Hlth & Epidemiol, Yufu, Oita 8795593, Japan.
EM nusmpublichealth@gmail.com
RI Itani, Osamu/AEN-6732-2022
OI Itani, Osamu/0000-0002-8526-785X
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NR 74
TC 40
Z9 45
U1 0
U2 30
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1389-9457
EI 1878-5506
J9 SLEEP MED
JI Sleep Med.
PD SEP
PY 2017
VL 37
BP 38
EP 45
DI 10.1016/j.sleep.2017.06.007
PG 8
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology
GA FG9XI
UT WOS:000410792900008
PM 28899538
DA 2025-06-11
ER

PT J
AU Demir, I
   Toker, A
   Aksoy, H
   Tasyurek, E
   Zengin, S
AF Demir, Irfan
   Toker, Aysun
   Aksoy, Hulya
   Tasyurek, Erkan
   Zengin, Selcuk
TI The Impact of Shift Type on Oxidative Stress, Inflammation, and Platelet
   Activation
SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
LA English
DT Article
DE inflammation; oxidative stress; platelet activation; rotating shift
ID LONG PENTRAXIN PTX3; METABOLIC SYNDROME; 8 HOUR; WORK; DISEASE; MARKERS;
   RECEPTOR; RISK; B-2
AB Objective: Rotating shift is known to disrupt circadian rhythms. The 12/24 shift system, with frequent day-night rotations and the ergonomic shift system (ESS), with 90% less rotations were compared for their impacts on oxidative stress, inflammation, and platelet activation by using pentraxin 3 (PTX3), urinary 15-isoprostane F2t, and 11-dehydrotromboxane B-2 (11-DTB2). Methods: All tests were performed by enzyme linked immunosorbent assay (ELISA). Unpaired t test and Pearson correlation analysis were employed. Results: Two hundred twenty 12/24 and 198 ESS workers were included. Plasma PTX3 and urinary 15-isoprostane F2t levels were not different between groups. Urinary 11-DTB2 in 12/24 workers were found significantly higher compared with ESS workers (P < 0.0001). A weak but significant correlation was found between urinary 15-isoprostane F2t and urinary 11-DTB2 levels (r = 0.17, P = 0.001). Conclusions: 12/24 rotating shift was found to cause platelet activation disturbances.
C1 [Toker, Aysun] Hipokrat Labs, Dept Biochem, TR-34725 Istanbul, Turkey.
   [Tasyurek, Erkan] Community Hlth Ctr, Karaman, Turkey.
RP Toker, A (corresponding author), Hipokrat Labs, Dept Biochem, TR-34725 Istanbul, Turkey.
EM aysuntoker@gmail.com
RI Demir, Ibrahim/ABI-4695-2020
FU Scientific and Technological Research Council of Turkey (TUBITAK)
FX This study was financially supported by a research fund from the
   Scientific and Technological Research Council of Turkey (TUBITAK).
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NR 34
TC 1
Z9 1
U1 0
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1076-2752
EI 1536-5948
J9 J OCCUP ENVIRON MED
JI J. Occup. Environ. Med.
PD MAR
PY 2021
VL 63
IS 3
BP E127
EP E131
DI 10.1097/JOM.0000000000002124
PG 5
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA SV3JQ
UT WOS:000663719200004
PM 33652448
DA 2025-06-11
ER

PT J
AU Sharma, P
   Verma, R
   Sharma, V
   Singh, TG
AF Sharma, Prateek
   Verma, Reet
   Sharma, Veerta
   Singh, Thakur Gurjeet
TI Targeting Cardiotoxicity Induced by Environmental Toxins: The Role of
   Natural Products
SO CARDIOVASCULAR TOXICOLOGY
LA English
DT Review; Early Access
DE Cardiotoxicity; Cardioprotection; Environmental toxins; Inflammation;
   Natural products; Oxidative stress
ID HEAVY-METAL POLLUTION; OXIDATIVE STRESS; METABOLIC SYNDROME;
   MITOCHONDRIAL DYSFUNCTION; PROTECTIVE ROLE; HERG CHANNEL; TOXICITY;
   ACID; QUERCETIN; EXPOSURE
AB Environmental toxins such as heavy metals, industrial pollutants, pesticides, and environmental chemicals are becoming recognized as key contributors to cardiotoxicity, with considerable implications for worldwide cardiovascular health. Humans are unintentionally exposed to environmental toxins, which have a variety of cardiopathologic effects. These poisons cause oxidative stress, inflammation, mitochondrial dysfunction, and dysregulation of important physiological pathways which ultimately contribute to cardiac dysfunction and diseases. Natural compounds originating from medicinal plants, microbes, and marine organisms have emerged as promising cardioprotective agents. These bioactive chemicals exhibit potent anti-oxidant, anti-inflammatory, and cardio-regenerative activities, which target molecular mechanisms involved in cardiotoxicity. Phytochemicals such as terpenoids, polyphenols, flavonoids, and alkaloids, as well as bioactive peptides and microbial metabolites, have shown promise in pre-clinical and clinical investigations for preventing toxin-induced cardiac damage. Therefore, this review highlights the mechanisms of environmental toxin-induced cardiotoxicity and the novel therapeutic agents for the prevention and treatment of environmental toxin-induced cardiotoxicity.
C1 [Sharma, Prateek; Verma, Reet; Sharma, Veerta; Singh, Thakur Gurjeet] Chitkara Univ, Chitkara Coll Pharm, Rajpura 140401, Punjab, India.
C3 Chitkara University, Punjab
RP Singh, TG (corresponding author), Chitkara Univ, Chitkara Coll Pharm, Rajpura 140401, Punjab, India.
EM Prateeksharma99155@gmail.com; Reetv04@gmail.com; veerta@chitkara.edu.in;
   gurjeet.singh@chitkara.edu.in
FU Chitkara College of Pharmacy, Chitkara University
FX The authors are grateful to the Chitkara College of Pharmacy, Chitkara
   University, Rajpura, Patiala, Punjab, India for providing the necessary
   facilities to carry out the research work.
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NR 98
TC 0
Z9 0
U1 0
U2 0
PU HUMANA PRESS INC
PI TOTOWA
PA 999 RIVERVIEW DRIVE SUITE 208, TOTOWA, NJ 07512 USA
SN 1530-7905
EI 1559-0259
J9 CARDIOVASC TOXICOL
JI Cardiovasc. Toxicol.
PD 2025 JUN 4
PY 2025
DI 10.1007/s12012-025-10005-7
EA JUN 2025
PG 13
WC Cardiac & Cardiovascular Systems; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Toxicology
GA 3JR2J
UT WOS:001501955200001
PM 40465026
DA 2025-06-11
ER

PT J
AU Clement, CC
   Nanaware, PP
   Yamazaki, T
   Negroni, MP
   Ramesh, K
   Morozova, K
   Thangaswamy, S
   Graves, A
   Kim, HJ
   Li, TWX
   Vigano', M
   Soni, RK
   Gadina, M
   Tse, HY
   Galluzzi, L
   Roche, PA
   Denzin, LK
   Stern, LJ
   Santambrogio, L
AF Clement, Cristina C.
   Nanaware, Padma P.
   Yamazaki, Takahiro
   Negroni, Maria Pia
   Ramesh, Karthik
   Morozova, Kateryna
   Thangaswamy, Sangeetha
   Graves, Austin
   Kim, Hei Jung
   Li, Tsai Wanxia
   Vigano', Marco
   Soni, Rajesh K.
   Gadina, Massimo
   Tse, Harley Y.
   Galluzzi, Lorenzo
   Roche, Paul A.
   Denzin, Lisa K.
   Stern, Lawrence J.
   Santambrogio, Laura
TI Pleiotropic consequences of metabolic stress for the major
   histocompatibility complex class II molecule antigen processing and
   presentation machinery
SO IMMUNITY
LA English
DT Article
ID GLYCATION END-PRODUCTS; OXIDATIVE STRESS; HLA-DM; NONENZYMATIC
   GLYCATION; ENDOTHELIAL-CELLS; CRYSTAL-STRUCTURE; T-CELLS;
   CARDIOVASCULAR-DISEASE; MASS-SPECTROMETRY; GLYOXALASE-I
AB Hyperglycemia and hyperlipidemia are often observed in individuals with type II diabetes (T2D) and related mouse models. One dysmetabolic biochemical consequence is the non-enzymatic reaction between sugars, lipids, and proteins, favoring protein glycation, glycoxidation, and lipoxidation. Here, we identified oxidative alterations in key components of the major histocompatibility complex (MHC) class II molecule antigen processing and presentation machinery in vivo under conditions of hyperglycemia-induced metabolic stress. These modifications were linked to epitope-specific changes in endosomal processing efficiency, MHC class II-peptide binding, and DM editing activity. Moreover, we observed some quantitative and qualitative changes in the MHC class II immunopeptidome of Ob/Ob mice on a high-fat diet compared with controls, including changes in the presentation of an apolipoprotein B100 peptide associated previously with T2D and metabolic syndrome-related clinical complications. These findings highlight a link between glycation reactions and altered MHC class II antigen presentation that may contribute to T2D complications.
C1 [Clement, Cristina C.; Yamazaki, Takahiro; Morozova, Kateryna; Thangaswamy, Sangeetha; Galluzzi, Lorenzo; Santambrogio, Laura] Weill Cornell Med, Dept Radiat Oncol, New York, NY 10065 USA.
   [Nanaware, Padma P.; Negroni, Maria Pia; Stern, Lawrence J.] Univ Massachusetts, Sch Med, Dept Pathol, Worcester, MA 01605 USA.
   [Ramesh, Karthik; Stern, Lawrence J.] Univ Massachusetts, Sch Med, Immunol & Microbiol Program, Worcester, MA 01605 USA.
   [Graves, Austin; Denzin, Lisa K.] Rutgers Robert Wood Johnson Med Sch, Child Hlth Inst New Jersey, New Brunswick, NJ USA.
   [Kim, Hei Jung; Roche, Paul A.] NCI, Expt Immunol Branch, NIH, Bethesda, MD 20892 USA.
   [Li, Tsai Wanxia; Gadina, Massimo] NIAMSD, Translat Immunol Sect, NIH, Bethesda, MD 20892 USA.
   [Vigano', Marco] Galeazzi Orthoped Inst Care & Sci Res, Orthoped Biotechnol Lab, Milan, Italy.
   [Soni, Rajesh K.] Columbia Univ, Herbert Irving Comprehens Canc Ctr, Prote & Macromol Crystallog Shared Resource, Irving Med Ctr, New York, NY USA.
   [Tse, Harley Y.] Wayne State Univ, Sch Med, Cardiovasc Res Inst, Dept Microbiol & Immunol, Detroit, MI USA.
   [Galluzzi, Lorenzo; Santambrogio, Laura] Sandra & Edward Meyer Canc Ctr, New York, NY 10065 USA.
   [Galluzzi, Lorenzo; Santambrogio, Laura] Caryl & Israel Englander Inst Precis Med, New York, NY 10065 USA.
C3 Cornell University; Weill Cornell Medicine; University of Massachusetts
   System; University of Massachusetts Worcester; University of
   Massachusetts System; University of Massachusetts Worcester; Rutgers
   University System; Rutgers University New Brunswick; Rutgers University
   Biomedical & Health Sciences; National Institutes of Health (NIH) - USA;
   NIH National Cancer Institute (NCI); National Institutes of Health (NIH)
   - USA; NIH National Institute of Arthritis & Musculoskeletal & Skin
   Diseases (NIAMS); Columbia University; NewYork-Presbyterian Hospital;
   Wayne State University
RP Santambrogio, L (corresponding author), Weill Cornell Med, Dept Radiat Oncol, New York, NY 10065 USA.; Stern, LJ (corresponding author), Univ Massachusetts, Sch Med, Dept Pathol, Worcester, MA 01605 USA.; Stern, LJ (corresponding author), Univ Massachusetts, Sch Med, Immunol & Microbiol Program, Worcester, MA 01605 USA.; Santambrogio, L (corresponding author), Sandra & Edward Meyer Canc Ctr, New York, NY 10065 USA.; Santambrogio, L (corresponding author), Caryl & Israel Englander Inst Precis Med, New York, NY 10065 USA.
EM lawrence.stern@umassmed.edu; las4011@med.cornell.edu
RI Galluzzi, Lorenzo/AAH-3286-2021; Sanchez-Prieto, Ricardo/B-6877-2008;
   Clement, Cristina/ABG-4525-2021; Nanaware, Padma/AAC-7567-2020
OI Ramesh, Karthik/0009-0001-3978-2922; Clement,
   Cristina/0000-0003-1464-407X
FU NIH [AI146180, AI137198]; Barile Children's Medical Research Trust;
   Robert Wood Johnson Foundation [67038]; Intramural Research Program of
   the National Institutes of Health; PHS [R01AI117535]
FX The work was supported by NIH AI146180 and NIH AI137198 (to L.S. and
   L.J.S.), PHS R01AI117535, The Barile Children's Medical Research Trust
   and the Robert Wood Johnson Foundation (67038 to the Child Health
   Institute of New Jersey) (to L.K.D.), and the Intramural Research
   Program of the National Institutes of Health (to P.A.R.).
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NR 88
TC 36
Z9 36
U1 1
U2 10
PU CELL PRESS
PI CAMBRIDGE
PA 50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA
SN 1074-7613
EI 1097-4180
J9 IMMUNITY
JI Immunity
PD APR 13
PY 2021
VL 54
IS 4
BP 721
EP +
DI 10.1016/j.immuni.2021.02.019
EA APR 2021
PG 26
WC Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology
GA RN1GO
UT WOS:000640102800013
PM 33725478
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Lardone, PJ
   Alvarez-Sánchez, N
   Guerrero, JM
   Carrillo-Vico, A
AF Lardone, P. J.
   Alvarez-Sanchez, N.
   Guerrero, J. M.
   Carrillo-Vico, A.
TI Melatonin and Glucose Metabolism: Clinical Relevance
SO CURRENT PHARMACEUTICAL DESIGN
LA English
DT Article
DE Diabetes; glucagon; glucose; insulin; melatonin; melatonin receptors;
   metabolic syndrome; oxidative stress
ID FASTING PLASMA-GLUCOSE; RECEPTOR MESSENGER-RNA; RAT PANCREATIC-ISLETS;
   GESTATIONAL DIABETES-MELLITUS; STIMULATED INSULIN-RELEASE; INDUCED
   OXIDATIVE STRESS; PRECURSOR L-TRYPTOPHAN; DIET-INDUCED OBESITY;
   GOTO-KAKIZAKI RATS; NF-KAPPA-B
AB The role of melatonin in glucose homeostasis is an active area of investigation. There is a growing body of evidence suggesting a link between disturbances in melatonin production and impaired insulin, glucose, lipid metabolism, and antioxidant capacity. Furthermore, melatonin has been found to influence insulin secretion both in vivo and in vitro, and night-time melatonin levels are related to night-time insulin concentrations in patients with diabetes. In several recent studies, a single nucleotide polymorphism of the human melatonin receptor 1B has been described as being causally linked to an increased risk of developing type 2 diabetes. Taken together, these data suggest that endogenous as well as exogenous melatonin may play a role in diabetes and associated metabolic disturbances not only by regulating insulin secretion but also by providing protection against reactive oxygen species, considering pancreatic beta-cells are particularly susceptible to oxidative stress because they possess only low-antioxidative capacity.
C1 [Carrillo-Vico, A.] Univ Seville, CSIC, Virgen del Rocio Univ Hosp, Inst Biomed Seville IBiS, Seville 41013, Spain.
   Univ Seville, CSIC, Virgen del Rocio Univ Hosp, Dept Med Biochem & Mol Biol, Seville 41013, Spain.
C3 Consejo Superior de Investigaciones Cientificas (CSIC); University of
   Sevilla; CSIC-JA-USE - Instituto de Biomedicina de Sevilla (IBIS);
   Virgen del Rocio University Hospital; University of Sevilla; Consejo
   Superior de Investigaciones Cientificas (CSIC); Virgen del Rocio
   University Hospital
RP Carrillo-Vico, A (corresponding author), Univ Seville, CSIC, Virgen del Rocio Univ Hosp, Inst Biomed Seville IBiS, Avda Manuel Siurot S-N, Seville 41013, Spain.
EM vico@us.es
RI Lardone, Patricia/H-1959-2015; Carrillo-Vico, Antonio/K-5265-2014;
   Alvarez-Sanchez, Nuria/A-2844-2013
OI Carrillo-Vico, Antonio/0000-0002-8516-0999; Guerrero, Juan
   Miguel/0000-0001-7553-0119; Alvarez-Sanchez, Nuria/0000-0002-1313-0440;
   Lardone, Patricia Judith/0000-0003-1793-3985
FU Instituto de Salud Carlos III; Ministerio de Economia y Competitividad
   [PI07/90175, RD06/0013/0001]; PAIDI Program from the Andalusian
   Government [CTS160]; Regional Government Ministry of Health
   [PI-0209-2010]
FX The authors are grateful for financial support from the Instituto de
   Salud Carlos III, Ministerio de Economia y Competitividad (PI07/90175
   and RD06/0013/0001), the PAIDI Program from the Andalusian Government
   (CTS160) and the Regional Government Ministry of Health (PI-0209-2010).
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NR 192
TC 34
Z9 35
U1 0
U2 15
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1381-6128
EI 1873-4286
J9 CURR PHARM DESIGN
JI Curr. Pharm. Design
PY 2014
VL 20
IS 30
BP 4841
EP 4853
PG 13
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA AN7TT
UT WOS:000340804600008
PM 24251676
DA 2025-06-11
ER

PT J
AU Mansur, RB
   Delgado-Peraza, F
   Subramaniapillai, M
   Lee, Y
   Iacobucci, M
   Nasri, F
   Rodrigues, N
   Rosenblat, JD
   Brietzke, E
   Cosgrove, VE
   Kramer, NE
   Suppes, T
   Raison, CL
   Fagiolini, A
   Rasgon, N
   Chawla, S
   Nogueras-Ortiz, C
   Kapogiannis, D
   McIntyre, RS
AF Mansur, Rodrigo B.
   Delgado-Peraza, Francheska
   Subramaniapillai, Mehala
   Lee, Yena
   Iacobucci, Michelle
   Nasri, Flora
   Rodrigues, Nelson
   Rosenblat, Joshua D.
   Brietzke, Elisa
   Cosgrove, Victoria E.
   Kramer, Nicole E.
   Suppes, Trisha
   Raison, Charles L.
   Fagiolini, Andrea
   Rasgon, Natalie
   Chawla, Sahil
   Nogueras-Ortiz, Carlos
   Kapogiannis, Dimitrios
   McIntyre, Roger S.
TI Exploring brain insulin resistance in adults with bipolar depression
   using extracellular vesicles of neuronal origin
SO JOURNAL OF PSYCHIATRIC RESEARCH
LA English
DT Article
DE Bipolar disorders; Insulin; Extracellular vesicles; Inflammation;
   TNF-alpha; Cognition
ID ALZHEIMERS-DISEASE; COGNITIVE FUNCTIONS; GLUCOSE REGULATION; METABOLIC
   SYNDROME; DIABETES-MELLITUS; OXIDATIVE STRESS; CONTROLLED-TRIAL; BLOOD
   EXOSOMES; DOUBLE-BLIND; TNF-ALPHA
AB Accumulating evidence suggests that disrupted insulin signaling is involved in bipolar disorder (BD) pathogenesis. Herein, we aimed to directly explore the potential role of neuronal insulin signaling using an innovative technique based on biomarkers derived from plasma extracellular vesicles enriched for neuronal origin (NEVs). We leveraged plasma samples from a randomized, double-blind, placebo-controlled, 12-week clinical trial evaluating infliximab as a treatment of bipolar depression. We isolated NEVs using immunoprecipitation against neuronal marker L1CAM from samples collected at baseline and weeks 2, 6 and 12 (endpoint) and measured NEV biomarkers using immunoassays. We assessed neuronal insulin signaling at its first node (IRS-1) and along the canonical (Akt, GSK-3 beta, p7056K) and alternative (ERK1/2, JNK and p38-MAPK) pathways. A subset of participants (n = 27) also underwent whole-brain magnetic resonance imaging (MRI) at baseline and endpoint. Pretreatment, NEV biomarkers of insulin signaling were independently associated with cognitive function and MRI measures (i.e. hippocampal and ventromedial prefrontal cortex [vmPFC] volumes). In fact, the association between IRS-1 phosphorylation at serine site 312 (p5312-IRS-1), an indicator of insulin resistance, and cognitive dysfunction was mediated by vmPFC volume. In the longitudinal analysis, patients treated with infliximab, a tumor necrosis factor-alpha antagonist with known insulin sensitizing properties, compared to those treated with placebo, had augmented phosphorylation of proteins from the alternative pathway. Infliximab responders had significant increases in phosphorylated JNK levels, relative to infliximab non-responders and placebo responders. In addition, treatment with infliximab resulted in increase in MRI measures of brain volume; treatment-related changes in the dorsolateral prefrontal cortex volume were mediated by changes in biomarkers from the insulin alternative pathway. In conclusion, our findings support the idea that brain insulin signaling is a target for further mechanistic and therapeutic investigations.
C1 [Mansur, Rodrigo B.; Subramaniapillai, Mehala; Lee, Yena; Iacobucci, Michelle; Nasri, Flora; Rodrigues, Nelson; Rosenblat, Joshua D.; McIntyre, Roger S.] Univ Hlth Network, Mood Disorders Psychopharmacol Unit, Toronto, ON, Canada.
   [Mansur, Rodrigo B.; Rosenblat, Joshua D.; McIntyre, Roger S.] Univ Toronto, Dept Psychiat, Toronto, ON, Canada.
   [Delgado-Peraza, Francheska; Chawla, Sahil; Nogueras-Ortiz, Carlos; Kapogiannis, Dimitrios] NIA, Lab Clin Invest, Intramural Res Program, NIH, Baltimore, MD 21224 USA.
   [Lee, Yena; McIntyre, Roger S.] Univ Toronto, Inst Med Sci, Toronto, ON, Canada.
   [Brietzke, Elisa] Queens Univ, Kingston Gen Hosp, Providence Care Hosp, Dept Psychiat,Sch Med, Kingston, ON, Canada.
   [Cosgrove, Victoria E.; Kramer, Nicole E.; Suppes, Trisha] Stanford Univ, Vet Affairs Hlth Care Syst, Sch Med, Dept Psychiat & Behav Sci, Palo Alto, CA 94304 USA.
   [Raison, Charles L.] Univ Wisconsin, Sch Human Ecol, Madison, WI USA.
   [Raison, Charles L.] Univ Wisconsin, Sch Med & Publ Hlth, Dept Psychiat, Madison, WI 53706 USA.
   [Fagiolini, Andrea] Univ Siena, Dept Mol Med, Siena, Italy.
   [Rasgon, Natalie] Stanford Univ, Ctr Neurosci Womens Hlth, Palo Alto, CA 94304 USA.
C3 University of Toronto; University Health Network Toronto; University of
   Toronto; National Institutes of Health (NIH) - USA; NIH National
   Institute on Aging (NIA); University of Toronto; Queens University -
   Canada; Queens University Hospital; US Department of Veterans Affairs;
   Veterans Health Administration (VHA); Stanford University; University of
   Wisconsin System; University of Wisconsin Madison; University of
   Wisconsin System; University of Wisconsin Madison; University of Siena;
   Stanford University
RP Kapogiannis, D (corresponding author), NIA, Intramural Res Program, NIH, 251 Bayview Blvd,Ste 8C228, Baltimore, MD 21224 USA.
EM kapogiannisd@mail.nih.gov
RI Mansur, Rodrigo/N-7131-2019; Lee, Yena/L-5505-2019; Kapogiannis,
   Dimitrios/AAW-4934-2020; Raison, Charles/N-6972-2018; McIntyre,
   Roger/AAU-1000-2020
OI Rosenblat, Joshua/0000-0002-4773-2191; Lee, Yena/0000-0003-0629-9456
FU Intramural Research Program of the National Institute on Aging, National
   Institutes of Health
FX This study was supported in part by the Intramural Research Program of
   the National Institute on Aging, National Institutes of Health.
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NR 77
TC 36
Z9 38
U1 2
U2 11
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-3956
EI 1879-1379
J9 J PSYCHIATR RES
JI J. Psychiatr. Res.
PD JAN
PY 2021
VL 133
BP 82
EP 92
DI 10.1016/j.jpsychires.2020.12.007
PG 11
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA PS3KS
UT WOS:000607825200012
PM 33316649
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Ding, YJ
   Xu, X
AF Ding, Yijian
   Xu, Xi
TI Dose- and Intensity-Response Associations Between Leisure-Time Physical
   Activity and Markers of Inflammation and Oxidative Stress in Older
   Adults
SO JOURNAL OF AGING AND PHYSICAL ACTIVITY
LA English
DT Article
DE albumin; C-reactive protein; multivariable linear regression; National
   Health and Nutrition Examination Survey
ID C-REACTIVE PROTEIN; CARDIOVASCULAR-DISEASE; EXERCISE INTENSITY;
   METABOLIC SYNDROME; POPULATION; BIOMARKERS; CANCER
AB This study aimed to investigate the dose- and intensity-response associations between leisure-time physical activity (LTPA) and markers of inflammation and oxidative stress in older adults. Multivariable linear regression was performed to evaluate the associations among 3,559 older adults in 2015-2018 National Health and Nutrition Examination Survey. LTPA was negatively associated with inflammatory markers including C-reactive protein, segmented neutrophil count and alkaline phosphatase, and positively associated with one marker of antioxidants albumin in older adults. Compared with vigorous LTPA, moderate LTPA could provide more benefits through further decreasing white blood cell count and alkaline phosphatase, and increasing serum bilirubin and albumin. The effects of LTPA on C-reactive protein and albumin were more significant in participants with chronic diseases including diabetes, hypertension, and cancer. In conclusion, this study demonstrates the dose- and intensity-response effects of LTPA on inflammation and oxidative stress and provides exercise prescription recommendations for older adults.
C1 [Ding, Yijian] Nanjing Univ Sci & Technol, Dept Phys Educ, Nanjing, Peoples R China.
   [Xu, Xi] Nanjing Univ Sci & Technol, Ctr Mol Metab, Nanjing, Peoples R China.
C3 Nanjing University of Science & Technology; Nanjing University of
   Science & Technology
RP Xu, X (corresponding author), Nanjing Univ Sci & Technol, Ctr Mol Metab, Nanjing, Peoples R China.
EM xuxi@njust.edu.cn
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   ,, 2010, Global recommendations on physical activity for health
NR 65
TC 9
Z9 9
U1 0
U2 6
PU HUMAN KINETICS PUBL INC
PI CHAMPAIGN
PA 1607 N MARKET ST, PO BOX 5076, CHAMPAIGN, IL 61820-2200 USA
SN 1063-8652
EI 1543-267X
J9 J AGING PHYS ACTIV
JI J. Aging Phys. Act.
PD DEC
PY 2022
VL 30
IS 6
BP 950
EP 962
DI 10.1123/japa.2021-0219
PG 13
WC Geriatrics & Gerontology; Gerontology; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Sport Sciences
GA 7P0RG
UT WOS:000908422000004
PM 35203054
DA 2025-06-11
ER

PT J
AU Pérez-López, FR
   Chedraui, P
   Gilbert, JJ
   Pérez-Roncero, G
AF Perez-Lopez, Faustino R.
   Chedraui, Peter
   Gilbert, Juan J.
   Perez-Roncero, Gonzalo
TI Cardiovascular risk in menopausal women and prevalent related co-morbid
   conditions: facing the post-Women's Health Initiative era
SO FERTILITY AND STERILITY
LA English
DT Review
DE Menopause; cardiovascular disease; hormone therapy; depression; sleeping
   disorders; vitamin D insufficiency; psychosocial factors; obesity
ID HORMONE-REPLACEMENT THERAPY; CORONARY-HEART-DISEASE; OBESE
   POSTMENOPAUSAL WOMEN; VASCULAR ENDOTHELIAL-CELLS; VITAMIN-D
   SUPPLEMENTATION; ENDOGENOUS SEX-HORMONES; SHORT-SLEEP DURATION;
   TREATMENT PANEL-III; MIDDLE-AGED WOMEN; QUALITY-OF-LIFE
AB Objective: To review scientific publications regarding cardiovascular risk during the menopausal years and that related to currently recognized highly prevalent co-morbid factors within this period.
   Methods: Citations were selected from a PubMed search and the authors' files according to their clinical and experimental relevance.
   Results and Discussion: Although experimental and some observational data have supported the fact that estrogens are beneficial for the female vascular system, these positive actions have been challenged by the results of the Women's Health Initiative trial and the Million Women Study, which demonstrated an increase in cardiovascular risk and related adverse events. The role of hormone therapy for the menopause has shifted from a preventive use to a limited role in symptom management, for which it remains the most effective intervention. Baseline evaluation of menopausal women should include individual cardiovascular risk assessment, including hypertension, dyslipidemia, elevated body weight, and the metabolic syndrome. Concomitantly, new factors influencing cardiovascular risk have been delineated among postmenopausal women, namely sleeping disorders, depression, vitamin D insufficiency, rheumatoid arthritis, sexual dysfunction, stress, and psychosocial factors. Therefore, a new landscape may be recognized for menopausal women management. Precise evaluation and treatment of each factor should be separately assessed to improve quality of life and reduce cardiovascular disease prevalence. At present, cardiovascular risk reduction strategies are a requisite (albeit underused) for menopausal women. These include education in terms of health, healthy lifestyle, and pharmacologic preventive interventions to reduce co-morbid conditions. (Fertil Steril (R) 2009;92:1171-86. (C) 2009 by American Society for Reproductive Medicine.)
C1 [Perez-Lopez, Faustino R.] Univ Zaragoza, Hosp Clin Univ Zaragoza, Dept Obstet & Gynaecol, Fac Med, E-50009 Zaragoza, Spain.
   [Chedraui, Peter; Gilbert, Juan J.] Univ Catolica Santiago Guayaquil, Inst Biomed, Guayaquil, Ecuador.
   [Perez-Roncero, Gonzalo] Inst Ginecol Zaragoza, Zaragoza, Spain.
C3 University of Zaragoza
RP Pérez-López, FR (corresponding author), Univ Zaragoza, Fac Med, Domingo Miral S-N, E-50009 Zaragoza, Spain.
EM faustino.perez@unizar.es
RI Blümel, Juan Enrique/JUV-6950-2023
OI Perez-Lopez, Faustino R./0000-0002-2801-416X
FU Spanish "Ministerio de Asuntos Exteriores y Cooperacion" [B/017543/08];
   Catholic University of Santiago de Guayaquil (Ecuador)
FX Partially supported by the B/017543/08 AECID ("Agencia Espanola de
   Cooperacion Internacional para el Desarrollo") grant from the Spanish
   "Ministerio de Asuntos Exteriores y Cooperacion" to the University of
   Zaragoza (Spain) and the Catholic University of Santiago de Guayaquil
   (Ecuador).
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NR 158
TC 109
Z9 125
U1 1
U2 28
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0015-0282
EI 1556-5653
J9 FERTIL STERIL
JI Fertil. Steril.
PD OCT
PY 2009
VL 92
IS 4
BP 1171
EP 1186
DI 10.1016/j.fertnstert.2009.06.032
PG 16
WC Obstetrics & Gynecology; Reproductive Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology; Reproductive Biology
GA 504KS
UT WOS:000270616100001
PM 19700149
OA Bronze
DA 2025-06-11
ER

PT J
AU Lewis, SA
   Britt, WM
   Koch, RL
   Razavi, AC
   Patel, P
   Sperling, LS
   D'Souza, MS
AF Lewis, Steven A.
   Britt, William M.
   Koch, Rachel L.
   Razavi, Alexander C.
   Patel, Parth
   Sperling, Laurence S.
   D'Souza, Melroy S.
TI Can age be a modifiable risk factor? the impact of dietary patterns on
   the molecular mechanisms that underlie cardiovascular aging
SO JOURNAL OF CARDIOVASCULAR AGING
LA English
DT Review
DE Cardiovascular aging; dietary patterns; chronic inflammation;
   epigenetics; oxidative stress
ID TERM CALORIE RESTRICTION; MEDITERRANEAN-STYLE DIET; C-REACTIVE PROTEIN;
   OXIDATIVE STRESS; DNA-METHYLATION; MITOCHONDRIAL BIOGENESIS; ENDOTHELIAL
   DYSFUNCTION; CARDIAC-HYPERTROPHY; METABOLIC SYNDROME; SKELETAL-MUSCLE
AB Aging is the number one risk factor for the development of cardiovascular disease (CVD). Therefore, an evaluation of therapies for the prevention of CVD should focus on factors that slow down aging, particularly cardiovascular aging. There are various proposed mechanisms that advance cardiovascular age; in this review, we focus on chronic inflammation, oxidative stress and epigenetics as the primary drivers of aging. Furthermore, we will evaluate several dietary patterns on their impact on these aging mechanisms. The traditional "heart-healthy" dietary patterns such as the Mediterranean diet, plant-based diet and intermittent fasting will be evaluated for their performance to slow down the aforementioned aging mechanisms. The aim of this review will be to guide practitioners and patients on the dietary components that can slow down the effects of aging to prevent CVD.
C1 [Lewis, Steven A.; Britt, William M.; Koch, Rachel L.; Razavi, Alexander C.] Emory Univ, Sch Med, Dept Med, Atlanta, GA 30307 USA.
   [Patel, Parth] Emory Univ, Sch Med, Div Hosp Med, Atlanta, GA 30307 USA.
   [Razavi, Alexander C.; Sperling, Laurence S.; D'Souza, Melroy S.] Emory Univ, Sch Med, Dept Cardiol, 101 Woodruff Circle,WMB 1105, Atlanta, GA 30322 USA.
C3 Emory University; Emory University; Emory University
RP D'Souza, MS (corresponding author), Emory Univ, Sch Med, Dept Cardiol, 101 Woodruff Circle,WMB 1105, Atlanta, GA 30322 USA.
EM msdsouz@emory.edu
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NR 198
TC 1
Z9 1
U1 0
U2 0
PU OAE PUBLISHING INC
PI ALHAMBRA
PA 245 E MAIN ST, ST122, ALHAMBRA, CA 91801 USA
EI 2768-5993
J9 J CARDIOVASC AGING
JI J. Cardiovasc. Aging
PD MAY
PY 2023
VL 3
IS 2
AR 14
DI 10.20517/jca.2023.1
PG 28
WC Cardiac & Cardiovascular Systems
WE Emerging Sources Citation Index (ESCI)
SC Cardiovascular System & Cardiology
GA I1Q1C
UT WOS:001328062500001
OA gold
DA 2025-06-11
ER

PT J
AU Silva, HM
   Báfica, A
   Rodrigues-Luiz, GF
   Chi, J
   Santos, PDA
   Reis, BS
   van Konijnenburg, DPH
   Crane, A
   Arifa, RDN
   Martin, P
   Mendes, DAGB
   Mansur, DS
   Torres, CJ
   Cadwell, K
   Cohen, P
   Mucida, D
   Lafaille, JJ
AF Silva, Hernandez Moura
   Bafica, Andre
   Rodrigues-Luiz, Gabriela Flavia
   Chi, Jingyi
   Alves Santos, Patricia d'Emery
   Reis, Bernardo S.
   Hoytema van Konijnenburg, David P.
   Crane, Audrey
   Nascimento Arifa, Raquel Duque
   Martin, Patricia
   Mendes, Daniel Augusto G. B.
   Mansur, Daniel Santos
   Torres, Ctor J.
   Cadwell, Ken
   Cohen, Paul
   Mucida, Daniel
   Lafaille, Juan J.
TI Vasculature-associated fat macrophages readily adapt to inflammatory and
   metabolic challenges
SO JOURNAL OF EXPERIMENTAL MEDICINE
LA English
DT Article
ID ADIPOSE-TISSUE MACROPHAGES; NECROSIS-FACTOR-ALPHA; BETA(3)-ADRENOCEPTOR
   AGONIST; MYCOBACTERIUM-TUBERCULOSIS; INSULIN-RESISTANCE; WEIGHT-LOSS;
   OBESITY; RECEPTOR; APOPTOSIS; CELLS
AB Tissue-resident macrophages are the most abundant immune cell population in healthy adipose tissue. Adipose tissue macrophages (ATMs) change during metabolic stress and are thought to contribute to metabolic syndrome. Here, we studied ATM subpopulations in steady state and in response to nutritional and infectious challenges. We found that tissue-resident macrophages from healthy epididymal white adipose tissue (eWAT) tightly associate with blood vessels, displaying very high endocytic capacity. We refer to these cells as vasculature-associated ATMs (VAMs). Chronic high-fat diet (HFD) results in the accumulation of a monocyte-derived CD11c(+)CD64(+ )double-positive (DP) macrophage eWAT population with a predominant anti-inflammatory/detoxifying gene profile, but reduced endocytic function. In contrast, fasting rapidly and reversibly leads to VAM depletion, while acute inflammatory stress induced by pathogens transiently depletes VAMs and simultaneously boosts DP macrophage accumulation. Our results indicate that ATM populations dynamically adapt to metabolic stress and inflammation, suggesting an important role for these cells in maintaining tissue homeostasis.
C1 [Silva, Hernandez Moura; Bafica, Andre; Alves Santos, Patricia d'Emery; Nascimento Arifa, Raquel Duque; Martin, Patricia; Cadwell, Ken; Lafaille, Juan J.] NYU, Sch Med, Skirball Inst, Kimmel Ctr Biol & Med, New York, NY 10003 USA.
   [Bafica, Andre; Rodrigues-Luiz, Gabriela Flavia; Mendes, Daniel Augusto G. B.; Mansur, Daniel Santos] Univ Fed Santa Catarina, Ctr Ciencias Biol, Dept Microbiol Imunol & Parasitol, Lab Imunobiol, Florianopolis, SC, Brazil.
   [Bafica, Andre; Reis, Bernardo S.; Hoytema van Konijnenburg, David P.; Mucida, Daniel] Rockefeller Univ, Lab Mucosal Immunol, 1230 York Ave, New York, NY 10021 USA.
   [Chi, Jingyi; Crane, Audrey; Cohen, Paul] Rockefeller Univ, Lab Mol Metab, 1230 York Ave, New York, NY 10021 USA.
   [Torres, Ctor J.; Cadwell, Ken] NYU, Sch Med, Dept Microbiol, New York, NY 10016 USA.
   [Lafaille, Juan J.] NYU, Sch Med, Dept Pathol, New York, NY 10016 USA.
C3 New York University; Universidade Federal de Santa Catarina (UFSC);
   Rockefeller University; Rockefeller University; New York University; New
   York University
RP Silva, HM (corresponding author), NYU, Sch Med, Skirball Inst, Kimmel Ctr Biol & Med, New York, NY 10003 USA.
EM hernandez.mourasilva@med.nyu.edu; juan.lafaille@med.nyu.edu
RI Hoytema van Konijnenburg, David/AAN-8626-2021; Rodrigues-Luiz,
   Gabriela/AAE-4937-2020; Bafica, Andre/ABF-5986-2020; Mansur,
   Daniel/AAQ-8062-2020; Mendes, Daniel/AAY-4058-2020; Sgarbi Reis,
   Bernardo/E-3448-2012; Santos, Patricia/L-2668-2018; Mansur,
   Daniel/KVB-4036-2024; Torres, Victor/JQW-7499-2023
OI Sgarbi Reis, Bernardo/0000-0002-6841-116X; Mucida,
   Daniel/0000-0002-0000-0452; Gasparin Bueno Mendes, Daniel
   Augusto/0000-0001-5655-0931; Santos, Patricia/0000-0003-4669-3343;
   Cadwell, Ken/0000-0002-5860-0661; Chi, Jingyi/0000-0001-6013-8544;
   Mansur, Daniel/0000-0001-6773-9334; Hoytema van Konijnenburg,
   David/0000-0001-5198-9718; Rodrigues-Luiz, Gabriela
   Flavia/0000-0003-3838-1008; Torres, Victor/0000-0002-7126-0489
FU National Center for Research Resources [S10 RR023704-01A1]; Laura and
   Isaac Perlmutter Cancer Center, Cancer Center Support Grant
   [P30CA016087]; National Council for Scientific and Technological
   Development; Computational Biology Program, Coordenacao de
   Aperfeicoamento de Pessoal de Nivel Superior
FX The NYU microscope core is supported by the National Center for Research
   Resources, grant S10 RR023704-01A1. NYU genomic core is a shared
   resource partially supported by the Laura and Isaac Perlmutter Cancer
   Center, Cancer Center Support Grant P30CA016087. H.M. Silva was
   supported by a fellowship from the National Council for Scientific and
   Technological Development and a postdoctoral fellowship from Dr. Bernard
   B. Levine. A. Bafica, G.F. Rodrigues-Luiz, D. Mucida, and D.S. Mansur
   were funded by the Computational Biology Program, Coordenacao de
   Aperfeicoamento de Pessoal de Nivel Superior.
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NR 73
TC 103
Z9 111
U1 0
U2 5
PU ROCKEFELLER UNIV PRESS
PI NEW YORK
PA 950 THIRD AVE, 2ND FLR, NEW YORK, NY 10022 USA
SN 0022-1007
EI 1540-9538
J9 J EXP MED
JI J. Exp. Med.
PD APR
PY 2019
VL 216
IS 4
BP 786
EP 806
DI 10.1084/jem.20181049
PG 21
WC Immunology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Research & Experimental Medicine
GA HR1CR
UT WOS:000462866300008
PM 30862706
OA Green Published, Green Submitted, hybrid
DA 2025-06-11
ER

PT J
AU Chen, JL
   Lei, YF
   Wu, GH
   Zhang, YH
   Fu, W
   Xiong, CM
   Ruan, JL
AF Chen, Jinglou
   Lei, Yongfang
   Wu, Guanghua
   Zhang, Yonghui
   Fu, Wei
   Xiong, Chaomei
   Ruan, Jinlan
TI Renoprotective potential of Macrothelypteris torresiana via
   ameliorating oxidative stress and proinflammatory cytokines
SO JOURNAL OF ETHNOPHARMACOLOGY
LA English
DT Article
DE Macrothelypteris torresiana; Nephrotic syndrome; Oxidative stress;
   Vascular endothelial growth factor; Nitric oxide
ID NITRIC-OXIDE SYNTHASE; GENTAMICIN-INDUCED NEPHROTOXICITY; ENDOTHELIAL
   GROWTH-FACTOR; INDUCED DIABETIC-RATS; PUROMYCIN-AMINONUCLEOSIDE;
   KIDNEY-TRANSPLANTATION; ANTIOXIDANT STATUS; NEPHROTIC SYNDROME;
   RENAL-CORTEX; NEPHROPATHY
AB Ethnopharmacological relevance: Macrothelypteris torresiana is traditionally used in Chinese folk medicine for the treatment of edema for patients suffering from kidney/bladder problems due to its satisfactory therapeutic effectiveness.
   Aim of the study:The aim of this study was to investigate the renoprotective nature of the total polyphenols fraction from Macrothelypteris torresiana (PMT).
   Materials and methods: The biochemical criterions of plasma and kidney tissues were evaluated to study the effects of PMT on puromycin aminonucleoside-induced chronic nephrotic syndrome (NS) in hyperlipidemic mice. Results: In this study, the NS and hyperlipidemia were ameliorated after 9 weeks administration of PMT. Besides, PMT was able to modulate the level of renal oxidative stress and vascular endothelial growth factor-nitric oxide (VEGF-NO) pathway.
   Conclusions: It represented a potential resource of PMT for the treatment of NS involved in metabolic syndrome. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
C1 [Chen, Jinglou; Lei, Yongfang; Wu, Guanghua; Zhang, Yonghui; Xiong, Chaomei; Ruan, Jinlan] Huazhong Univ Sci & Technol, Coll Pharm, Key Lab Nat Med Chem & Resource Evaluat Hubei Pro, Tongji Med Ctr, Wuhan 430030, Hubei Province, Peoples R China.
   [Fu, Wei] Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Dept Pharm, Wuhan 430030, Hubei Province, Peoples R China.
C3 Huazhong University of Science & Technology; Huazhong University of
   Science & Technology
RP Zhang, YH (corresponding author), Huazhong Univ Sci & Technol, Coll Pharm, Key Lab Nat Med Chem & Resource Evaluat Hubei Pro, Tongji Med Ctr, 13 Hangkong Rd, Wuhan 430030, Hubei Province, Peoples R China.
EM yfleiwolftree@163.com; zhangyh@mails.tjmu.edu.cn; jinlan8152@163.com
RI Zhang, Yonghui/AGY-5688-2022
FU State Natural Sciences Fund [NO30973864]; Ministry of Education
   [NO20090142110021]; Key Natural Science Fund of Hubei Province
   [NO2009CDA067]
FX The authors thank Prof. Ceming Tan from the Jiujiang Forest Plants
   Specimen Mansion for the identification of the plant, the financial
   support from the State Natural Sciences Fund (NO30973864), the Ministry
   of Education Fund for Doctoral Program of higher subjects
   (NO20090142110021) and the Key Natural Science Fund of Hubei Province
   (NO2009CDA067).
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NR 41
TC 8
Z9 10
U1 0
U2 13
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0378-8741
J9 J ETHNOPHARMACOL
JI J. Ethnopharmacol.
PD JAN 6
PY 2012
VL 139
IS 1
BP 207
EP 213
DI 10.1016/j.jep.2011.11.002
PG 7
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA 888AT
UT WOS:000299976900028
PM 22101083
DA 2025-06-11
ER

PT J
AU Singh, NR
   Rondeau, P
   Hoareau, L
   Bourdon, E
AF Singh, Nihar Ranjan
   Rondeau, Philippe
   Hoareau, Laurence
   Bourdon, Emmanuel
TI Identification of preferential protein targets for carbonylation in
   human mature adipocytes treated with native or glycated albumin
SO FREE RADICAL RESEARCH
LA English
DT Article
DE glycation; albumin; adipocytes; oxidative stress; oxidation; carbonyls
ID BOVINE SERUM-ALBUMIN; OXIDATIVE STRESS; DICHLOROFLUORESCEIN ASSAY;
   ALDEHYDE DEHYDROGENASE; ANTIOXIDANT PROPERTIES; METABOLIC SYNDROME;
   MOUSE ADIPOCYTES; REDOX REGULATION; ADIPOSE-TISSUE; FREE-RADICALS
AB Oxidative modifications in proteins can participate in the regulation of cellular functions and are frequently observed in numerous states of diseases. Albumin can undergo increased glycation during diabetes. An accumulation of oxidatively modified proteins in human mature adipocytes incubated with glycated albumin has previously been described. This study herein reports the identification of specifically carbonylated targets following separation of the cell proteins by 2D gels, Western blotting and mass spectrometry analyses. It identified eight oxidatively modified proteins, two of which ( ACTB and Annexin A2) appeared as significantly more carbonylated in adipocytes treated with glycated albumin than with native albumin. Intracellular stress, evaluated in SW872 cell line, showed an impairment in the protective antioxidant action exerted by native BSA after the glycation of the protein. Decreased proteasome peptidase activities were found in glycated BSA-treated mature adipocytes. The data suggest an association of oxidative damage with the progression of diabetes disorders at the adipocytes level.
C1 Univ Reunion, LBGM, St Denis 97715 09, Reunion, France.
C3 University of La Reunion
RP Bourdon, E (corresponding author), Univ Reunion, LBGM, 15 Ave Rene Cassin,BP 7151, St Denis 97715 09, Reunion, France.
EM emmanuel.bourdon@univ-reunion.fr
RI Singh, NIHAR/AAQ-3492-2020; Bourdon, Emmanuel/P-8455-2019; rondeau,
   philippe/Q-1967-2019
OI Hoareau, Laurence/0000-0003-3104-0120; Singh, Nihar
   Ranjan/0000-0002-4784-2163; Bourdon, Emmanuel/0000-0003-3731-150X
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NR 47
TC 34
Z9 38
U1 0
U2 3
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1071-5762
EI 1029-2470
J9 FREE RADICAL RES
JI Free Radic. Res.
PY 2007
VL 41
IS 10
BP 1078
EP 1088
DI 10.1080/10715760701487674
PG 11
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 217OX
UT WOS:000249958300002
PM 17886029
DA 2025-06-11
ER

PT J
AU Zheng, H
   Wu, JZ
   Jin, Z
   Yan, LJ
AF Zheng, Hong
   Wu, Jinzi
   Jin, Zhen
   Yan, Liang-Jun
TI Potential Biochemical Mechanisms of Lung Injury in Diabetes
SO AGING AND DISEASE
LA English
DT Review
DE diabetic hyperglycemia; diabetic lung injury; diabetes mellitus;
   mitochondria; oxidative stress
ID GLYCATION END-PRODUCTS; FACTOR-KAPPA-B; OXIDATIVE STRESS; MITOCHONDRIAL
   DYSFUNCTION; ADVANCED GLYCOSYLATION; PULMONARY-FUNCTION; MACROVASCULAR
   COMPLICATIONS; ANTIOXIDANT STATUS; METABOLIC SYNDROME; GLYCEMIC CONTROL
AB Accumulating evidence has shown that the lung is one of the target organs for microangiopathy in patients with either type 1 or type 2 diabetes mellitus (DM). Diabetes is associated with physiological and structural abnormalities in the diabetic lung concurrent with attenuated lung function. Despite intensive investigations in recent years, the pathogenic mechanisms of diabetic lung injury remain largely elusive. In this review, we summarize currently postulated mechanisms of diabetic lung injury. We mainly focus on the pathogenesis of diabetic lung injury that implicates key pathways, including oxidative stress, non-enzymatic protein glycosylation, polyol pathway, NF-kappa B pathway, and protein kinase c pathway. We also highlight that while numerous studies have mainly focused on tissue or cell damage in the lung, studies focusing on mitochondrial dysfunction in the diabetic lung have remained sketchy. Hence, further understanding of mitochondrial mechanisms of diabetic lung injury should provide invaluable insights into future therapeutic approaches for diabetic lung injury.
C1 [Zheng, Hong; Wu, Jinzi; Jin, Zhen; Yan, Liang-Jun] Univ North Texas, Hlth Sci Ctr, UNT Syst Coll Pharm, Dept Pharmaceut Sci, Ft Worth, TX 76107 USA.
   [Zheng, Hong] Shandong Univ Tradit Chinese Med, Coll Basic Med, Dept Basic Theory Tradit Chinese Med, Jinan 250355, Shandong, Peoples R China.
C3 University of North Texas System; University of North Texas Denton;
   Shandong University of Traditional Chinese Medicine
RP Yan, LJ (corresponding author), Univ North Texas, Hlth Sci Ctr, UNT Syst Coll Pharm, Dept Pharmaceut Sci, Ft Worth, TX 76107 USA.
EM liang-jun.yan@unthsc.edu
OI Jin, Zhen/0000-0003-0540-5173; Yan, Liang-Jun/0000-0002-5815-5430
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NR 110
TC 74
Z9 76
U1 2
U2 18
PU INT SOC AGING & DISEASE
PI FORT WORTH
PA EDITORIAL OFF, 3400 CAMP BOWIE BLVD, FORT WORTH, TX 76106 USA
SN 2152-5250
J9 AGING DIS
JI Aging Dis.
PD FEB
PY 2017
VL 8
IS 1
BP 7
EP 16
DI 10.14336/AD.2016.0627
PG 10
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA EQ5MM
UT WOS:000398126900002
PM 28203478
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Abdallah, MS
   Eldeen, AH
   Tantawy, SS
   Mostafa, TM
AF Abdallah, Mahmoud Samy
   Eldeen, Ahmed Hossam
   Tantawy, Sally Said
   Mostafa, Tarek Mohamed
TI The leukotriene receptor antagonist montelukast in the treatment of
   non-alcoholic steatohepatitis: A proof-of-concept, randomized,
   double-blind, placebo-controlled trial
SO EUROPEAN JOURNAL OF PHARMACOLOGY
LA English
DT Article
DE NASH; Montelukast; TNF-alpha; 8-OHdG; HA; TGF-beta 1; Liver stiffness
ID FATTY LIVER-DISEASE; INSULIN-RESISTANCE; OXIDATIVE STRESS; NONINVASIVE
   ASSESSMENT; METABOLIC SYNDROME; DNA-DAMAGE; FIBROSIS; PENTOXIFYLLINE;
   PLASMA; MODEL
AB Non-alcoholic fatty liver disease (NAFLD) is associated with fat accumulation in the liver which can progress into non-alcoholic steatohepatitis (NASH). There is no specific treatment strategy for NASH. In this context, this study aimed at evaluating the efficacy and safety of montelukast in the treatment of patients with NASH. In this randomized double-blind placebo-controlled study, 52 overweight/obese patients with NASH were randomized into group 1 (n = 26) which received montelukast 10 mg tablets once daily and group 2 (n = 26) which received placebo tablets once daily for 12 weeks. The fibro-scan was used to assess liver stiffness as a primary outcome at baseline and 12 weeks post-treatment. Furthermore, patients were assessed for biochemical analysis of liver aminotransferases, metabolic parameters, TNF-alpha, 8-hydroxy-2 '-deoxyguanosine (8-OHdG), liver fibrosis biomarkers including hyaluronic acid (HA) and transforming growth factor beta-1 (TGF-beta 1). Beck depression inventory questionnaire was used to report depressive symptoms. Data were statistically analyzed by paired and unpaired student's t-test, and Chi-square test. A total number of 44 patients completed the study. The two groups were statistically similar at baseline. After treatment and as compared to baseline data and placebo, montelukast showed a statistically significant improvement in liver stiffness, liver enzymes, metabolic parameters (except LDL-C), TNF-alpha, 8-OHdG, and liver fibrosis biomarkers (HA and TGF-beta 1). Furthermore, montelukast was well tolerated and didn't provoke depression. In this proof-of-concept study, treatment with montelukast may represent a promising therapeutic strategy for patients with non-alcoholic steatohepatitis secondary to its efficacy and safety.
C1 [Abdallah, Mahmoud Samy] Univ Sadat City USC, Fac Pharm, Dept Clin Pharm, Menoufia 32897, Egypt.
   [Eldeen, Ahmed Hossam] Menoufia Univ, Natl Liver Inst, Dept Hepatol, Menoufia, Egypt.
   [Tantawy, Sally Said] Shebin El Kom Hosp Fever, Gastrointestinal & Hepat Dis, Menoufia, Egypt.
   [Mostafa, Tarek Mohamed] Tanta Univ, Fac Pharm, Dept Clin Pharm, Tanta, Egypt.
C3 Egyptian Knowledge Bank (EKB); University of Sadat City; Egyptian
   Knowledge Bank (EKB); Menofia University; Egyptian Knowledge Bank (EKB);
   Tanta University
RP Abdallah, MS (corresponding author), Univ Sadat City USC, Fac Pharm, Dept Clin Pharm, Menoufia 32897, Egypt.; Mostafa, TM (corresponding author), Tanta Univ, Fac Pharm, Dept Clin Pharm, Tanta, Egypt.
EM Mahmoud.samy@fop.usc.edu.eg; Ashhossam2000@yahoo.com;
   Sallysaid016@gmail.com; tarek.mostafa@pharm.tanta.edu.eg
RI Abdallah, Mahmoud/G-7905-2017
OI Mohamed Mostafa, Tarek/0000-0003-1071-5416
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NR 56
TC 6
Z9 7
U1 0
U2 24
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0014-2999
EI 1879-0712
J9 EUR J PHARMACOL
JI Eur. J. Pharmacol.
PD SEP 5
PY 2021
VL 906
AR 174295
DI 10.1016/j.ejphar.2021.174295
EA JUL 2021
PG 8
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA TX4CT
UT WOS:000683036900003
PM 34214585
DA 2025-06-11
ER

PT J
AU Wroolie, TE
   Kenna, HA
   Singh, MK
   Rasgon, NL
AF Wroolie, Tonita E.
   Kenna, Heather A.
   Singh, Manpreet K.
   Rasgon, Natalie L.
TI Association between insulin resistance and cognition in patients with
   depressive disorders: Exploratory analyses into age-specific effects
SO JOURNAL OF PSYCHIATRIC RESEARCH
LA English
DT Article
DE Insulin resistance; Depression; Obesity; Cognition; Family history of
   diabetes; Age
ID ALZHEIMERS-DISEASE; METABOLIC SYNDROME; MAJOR DEPRESSION; SUPPRESSION
   TEST; OLDER-PEOPLE; TYPE-2; SYMPTOMS; OBESITY; ADULTS; GLUCOREGULATION
AB The current preliminary cross sectional study sought to examine the effects of insulin resistance (IR) and body mass index (BMI) on cognitive performance in adult patients with a history depression, currently not in an acute Major Depressive Episode (MDD). As an exploratory post hoc investigation, special consideration was given to adults <45 years and >= 45 years old.
   Subjects included men and women ages 19-71 (N = 39) with a history of a non-psychotic, non-melancholic MDD. All subjects underwent an insulin suppression test to determine Steady-State Plasma Glucose (SSPG), a battery of neuropsychological tests, and measurement of BMI. Multiple linear regressions were conducted to determine whether there were differential effects of direct (SSPG) and indirect (BMI) measures on cognition in the whole sample and within dichotomized age groups (<45 and >= 45 years).
   Preliminary results showed that in the sample as a whole, SSPG was not associated with worse performance on any cognitive variables, while higher BMI was associated with worse dominant hand fine motor skills. Within age groups, differential effects on cognition were found in relation to SSPG and BMI. Higher SSPG was associated with worse cognitive flexibility in the group <45 years, whereas higher BMI was associated with worse estimate of global intelligence in the group >= 45 years.
   The potential negative impact of IR in younger adults with depression raises concerns regarding the long-term impact on cognition and risk for Alzheimer's disease in undiagnosed younger adults with IR and depression. These negative consequences may not be seen with indirect measures of IR in younger adult populations. Overweight and obesity in older adults with a history of depression appear to have further negative impacts on cognition similar to deficits seen in patients with diabetes. ClinicalTrials.gov Identifier: Clinical Trial NCT01106313 (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Wroolie, Tonita E.; Kenna, Heather A.; Singh, Manpreet K.; Rasgon, Natalie L.] Stanford Univ, Sch Med, Dept Psychiat & Behav Sci, Stanford, CA 94305 USA.
C3 Stanford University
RP Rasgon, NL (corresponding author), Stanford Univ, Sch Med, Dept Psychiat & Behav Sci, 401 Quarry Rd, Stanford, CA 94305 USA.
EM nrasgon@stanford.edu
RI Rasgon, Natalie/ABH-9813-2020; Singh, Manpreet/L-1068-2014
OI Singh, Manpreet/0000-0002-4373-3293
FU American Diabetes Association [709050]; National Center for Research
   Resources, National Institutes of Health [M01 RR-00070]
FX This study was funded by grant 709050 from the American Diabetes
   Association and supported in part by grant M01 RR-00070 from the
   National Center for Research Resources, National Institutes of Health.
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NR 43
TC 17
Z9 17
U1 0
U2 22
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-3956
EI 1879-1379
J9 J PSYCHIATR RES
JI J. Psychiatr. Res.
PD JAN
PY 2015
VL 60
BP 65
EP 72
DI 10.1016/j.jpsychires.2014.10.001
PG 8
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA AY0DR
UT WOS:000347268500008
PM 25455511
DA 2025-06-11
ER

PT J
AU Peterson, SJ
   Vanella, L
   Gotlinger, K
   Jiang, HL
   Singh, SP
   Sodhi, K
   Maher, E
   O'Hanlon, K
   Shapiro, JI
   Abraham, NG
AF Peterson, Stephen J.
   Vanella, Luca
   Gotlinger, Katherine
   Jiang, Houli
   Singh, Shailendra P.
   Sodhi, Komal
   Maher, Eamonn
   O'Hanlon, Kathleen
   Shapiro, Joseph I.
   Abraham, Nader G.
TI Oxidized HDL is a potent inducer of adipogenesis and causes activation
   of the Ang-II and 20-HETE systems in human obese females
SO PROSTAGLANDINS & OTHER LIPID MEDIATORS
LA English
DT Article
DE Female; Obesity; Inflammation; OX-HDL; 20-HETE; Isoprostane;
   Adiponectin; Angiotensin ll
ID HIGH-DENSITY-LIPOPROTEIN; CELL-DERIVED ADIPOCYTES; RENIN-ANGIOTENSIN
   SYSTEM; ACUTE CORONARY SYNDROMES; HEME OXYGENASE HO-1; HIGH-FAT DIET;
   20-HYDROXYEICOSATETRAENOIC ACID; VASCULAR DYSFUNCTION; OXIDATIVE STRESS;
   GENE-EXPRESSION
AB Background: Oxidized-HDL (OX-HDL) has been reported to increase coronary events in obese patients; however, OX-HDL has not been studied in subjects with the metabolic syndrome. A high body mass index (BMI) correlates positively with higher levels of metabolic syndrome biomarkers including vasoconstrictors and adipokines. We hypothesize that a subject with a high BMI would present with higher levels of OX-HDL, 20-HETE and Angiotensin II (Ang II) with a reciprocal reduction in serum adiponectin.
   Methods: Female subjects with a BMI of 17-25 and a BMI of 30-40, without overt cardiovascular disease, were enrolled in the study. All patients had a history and physical exam documenting the absence of signs and symptoms of cardiovascular disease. Appropriate screening was done and documented. Blood pressure was taken at two discrete points. The BP data are presented as the average. Changes in the relationship between BMI, OX-HDL, 20-HETE, Ang II, TNF alpha, isoprostane and adiponectin were examined. In addition, the effects of OX-HDL, 20-HETE and Ang II on adipogenesis were examined in human MSC derived adipocytes.
   Results: Subjects with a high BMI>30 displayed an increase in OX-HDL and isoprostane (P<0.05) compared to those with the lower BMI<25 which was associated with an increase in Ang II and 20-HETE (p<0.05). Serum TNFa levels increased in subjects with a high BMI, compared to subjects with the lower BMI (p<0.05). In contrast, adiponectin levels were increased in subjects with a low BMI compared to obese subjects (p<0.05). In MSC derived adipocytes OX-HDL increased adipogenesis 6 fold at a concentration of 50 ng compared to untreated adipocytes. Adipocytes treated with Ang II and 20-HETE also displayed increased adipogenesis (p<0.05), which was attenuated by endogenous increases of the anti-oxidant heme oxygenase-1. Our study demonstrates that OX-HDL presents a unique inflammatory biomarker profile in obese females with the metabolic syndrome at risk for developing cardiovascular disease.
   Conclusions: Females with increased BMI (30-40) exhibit a marked increase in OX-HDL and isoprostane levels, which was associated with an increase in 20-HETE, TNF alpha and Ang II and decreased levels of adiponectin when compared to a group with a low BMI. OX-HDL had a more powerful adipogenic effect when compared to 20-HETE and Ang II. Our study demonstrates that OX-HDL presents a unique inflammatory biomarker profile in obese females with the metabolic syndrome at risk for developing cardiovascular disease. This represents a novel mechanism by which females with a high BMI and controlled blood pressure remain "at risk" for the development of the metabolic syndrome as a result of increased adipogenesis by OX-HDL and activation of the 20-HETE and Ang II systems. (C) 2016 Elsevier Inc. All rights reserved.
C1 [Vanella, Luca; Gotlinger, Katherine; Jiang, Houli; Singh, Shailendra P.; Abraham, Nader G.] New York Med Coll, Dept Pharmacol, Valhalla, NY 10595 USA.
   [Peterson, Stephen J.; Abraham, Nader G.] New York Med Coll, Dept Med, Valhalla, NY 10595 USA.
   [Sodhi, Komal; Maher, Eamonn; O'Hanlon, Kathleen; Shapiro, Joseph I.; Abraham, Nader G.] Marshall Univ, Joan C Edwards Sch Med, Huntington, WV 25701 USA.
   [Vanella, Luca] Univ Catania, Dept Drug Sci, Sect Biochem, Catania, Italy.
   [Peterson, Stephen J.] New York Methodist Hosp, Dept Med, Weill Cornell Med Coll, Brooklyn, NY 11215 USA.
C3 New York Medical College; New York Medical College; Marshall University;
   University of Catania; NewYork-Presbyterian Hospital;
   NewYork-Presbyterian Brooklyn Methodist Hospital; Cornell University;
   Weill Cornell Medicine
RP Peterson, SJ (corresponding author), New York Methodist Hosp, Chair Med, Weill Cornell Med Coll, Internal Med, Brooklyn, NY 11215 USA.
EM sjpmunger@icloud.com
RI Maher, Eamonn/AAA-9430-2022; Vanella, Luca/J-7354-2016; SINGH,
   SHAILENDRA PRATAP/R-8524-2018
OI SINGH, SHAILENDRA PRATAP/0000-0003-2996-0374
FU National Institutes of Health [HL-34300, HL-55561, HL-109015];
   Brick-street Foundation; Huntington Foundation
FX All authors had full access to the data and take responsibility for its
   integrity. All authors have read and agreed with the manuscript as
   written. This work was supported by National Institutes of Health grants
   HL-34300, HL-55561, and HL-109015 (NGA) and the Brick-street Foundation
   and the Huntington Foundation (NGA, JIS). We thank Dr. Kim for his
   contribution of his expertise in adipogenesis measurement. We also thank
   Ms. Morghan Getty and Hayden Ansinelli for their technical assistance,
   Dr. M.L. Schwartzman for expert comments, and Dr. George S. Drummond for
   his expertise and editorial comments. We thank Jennifer Brown and Gail
   Anderson for their outstanding editorial assistance in the preparation
   of the manuscript.
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PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
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J9 PROSTAG OTH LIPID M
JI Prostaglandins Other Lipid Mediat.
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EF﻿FN Clarivate Analytics Web of Science
VR 1.0
PT J
AU Münzel, T
   Kuntic, M
   Daiber, A
   Sorensen, M
AF Muenzel, Thomas
   Kuntic, Marin
   Daiber, Andreas
   Sorensen, Mette
TI Transportation noise and the cardiometabolic risk
SO ATHEROSCLEROSIS
LA English
DT Article
DE Transportation noise; Stress hormones; Inflammation and oxidative
   stress; Metabolic dysregulation; Diabetes mellitus
ID TRAFFIC NOISE; AIRCRAFT NOISE; CARDIOVASCULAR-DISEASE; ENDOTHELIAL
   FUNCTION; ENVIRONMENTAL NOISE; AIR-POLLUTION; EXPOSURE; ROAD;
   HYPERTENSION; METAANALYSIS
AB Transportation noise is a widespread and often underestimated environmental pollutant, posing a substantial health risk particularly in urban areas. In contrast to air pollution, the health effects of noise pollution are less extensively documented. Defined as an unwanted and/or harmful sound, noise pollution affects over 20 % of the European Union (EU) population, contributing to an estimated 12,000 premature deaths and 48,000 new cases of ischemic heart disease annually. Recent epidemiological evidence strengthens the link between transportation noise and cardiovascular disease (CVD). A 2024 Umbrella + review with subsequent meta-analyses found that road traffic noise was associated with risk of CVD, more specifically a 4.1 % higher risk for ischemic heart disease, 4.6 % for stroke, and 4.4 % for heart failure per 10 dB(A). Translational and experimental studies have investigated the biological mechanisms behind noise-induced cardiovascular damage, showing that noise impacts stress and sleep pathways. Human studies reveal that nighttime noise impairs vascular function, elevates stress hormone levels, and triggers inflammation and oxidative stress, particularly in individuals with pre-existing CVD. Animal research corroborates these findings, demonstrating that noise exposure leads to endothelial dysfunction, elevated blood pressure, and oxidative stress through mechanisms shared with traditional cardiovascular risk factors. Mitigation strategies are crucial to reducing the health impacts of environmental noise. For road traffic, transitioning to electric vehicles offers minimal noise reduction, necessitating measures such as noise-reducing asphalt, low-noise tyres, and changes in urban infrastructure, whereas for aircraft noise nighttime flight bans and optimized flight paths are important tools for reducing noise exposure. Addressing co-exposure to noise and air pollution is essential for a comprehensive approach to mitigating the environmental burden on cardiovascular health.
C1 [Muenzel, Thomas; Kuntic, Marin; Daiber, Andreas] Univ Med Ctr Mainz, Dept Cardiol, Mainz, Germany.
   [Sorensen, Mette] Danish Canc Soc, Danish Canc Inst, Copenhagen, Denmark.
   [Sorensen, Mette] Roskilde Univ, Dept Nat Sci & Environm, Roskilde, Denmark.
C3 Johannes Gutenberg University of Mainz; Danish Cancer Society; Roskilde
   University
RP Münzel, T (corresponding author), Johannes Gutenberg Univ Mainz, Univ Med Ctr Mainz, Langenbeckstr 1, D-55131 Mainz, Germany.
EM tmuenzel@uni-mainz.de
RI Daiber, Andreas/HJY-5274-2023; Muenzel, Thomas/A-2912-2014
OI Muenzel, Thomas/0000-0001-5503-4150
FU Environmental network EXPOHEALTH - Science Initiative of the state
   Rhineland-Palatinate, Germany; European Union [101156161]; Swiss State
   Secretariat for Education, Research and Innovation (SERI)
FX T.M. is PI of the German Cardiovascular Research Center (DZHK), Partner
   Site Rhine Main, Mainz. The collaboration of the authors was funded by
   the environmental network EXPOHEALTH funded by the Science Initiative of
   the state Rhineland-Palatinate, Germany. The present MS is funded by the
   European Union (Grant Agreement Number 101156161) and the Swiss State
   Secretariat for Education, Research and Innovation (SERI). Views and
   opinions expressed are, however, those of the author(s) only and do not
   necessarily reflect those of the European Union, the European Health and
   Digital Executive Agency (HADEA) or the SERI.
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PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0021-9150
EI 1879-1484
J9 ATHEROSCLEROSIS
JI Atherosclerosis
PD APR
PY 2025
VL 403
AR 119148
DI 10.1016/j.atherosclerosis.2025.119148
PG 11
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 1WL6G
UT WOS:001475285600001
PM 40055082
OA hybrid
DA 2025-06-11
ER

PT J
AU Eraly, SA
   Nievergelt, CM
   Maihofer, AX
   Barkauskas, DA
   Biswas, N
   Agorastos, A
   O'Connor, DT
   Baker, DG
AF Eraly, Satish A.
   Nievergelt, Caroline M.
   Maihofer, Adam X.
   Barkauskas, Donald A.
   Biswas, Nilima
   Agorastos, Agorastos
   O'Connor, Daniel T.
   Baker, Dewleen G.
CA Marine Resiliency Study Team
TI Assessment of Plasma C-Reactive Protein as a Biomarker of Posttraumatic
   Stress Disorder Risk
SO JAMA PSYCHIATRY
LA English
DT Article
ID METABOLIC SYNDROME; MENTAL-HEALTH; DEPRESSIVE SYMPTOMS; CARDIOVASCULAR
   RISK; ALCOHOL-CONSUMPTION; INFLAMMATION; PTSD; ASSOCIATION; MOOD;
   VETERANS
AB IMPORTANCE Posttraumatic stress disorder (PTSD) has been associated in cross-sectional studies with peripheral inflammation. It is not known whether this observed association is the result of PTSD predisposing to inflammation (as sometimes postulated) or to inflammation predisposing to PTSD.
   OBJECTIVE To determine whether plasma concentration of the inflammatory marker C-reactive protein (CRP) helps predict PTSD symptoms.
   DESIGN, SETTING, AND PARTICIPANTS The Marine Resiliency Study, a prospective study of approximately 2600 war zone-deployed Marines, evaluated PTSD symptoms and various physiological and psychological parameters before deployment and at approximately 3 and 6 months following a 7-month deployment. Participants were recruited from 4 all-male infantry battalions imminently deploying to a war zone. Participation was requested of 2978 individuals; 2610 people (87.6%) consented and 2555 (85.8%) were included in the present analysis. Postdeployment data on combat-related trauma were included for 2208 participants (86.4% of the 2555 included) and on PTSD symptoms at 3 and 6 months after deployment for 1861 (72.8%) and 1617 (63.3%) participants, respectively.
   MAIN OUTCOMES AND MEASURES Severity of PTSD symptoms 3 months after deployment assessed by the Clinician-Administered PTSD Scale (CAPS).
   RESULTS We determined the effects of baseline plasma CRP concentration on postdeployment CAPS using zero-inflated negative binomial regression (ZINBR), a procedure designed for distributions, such as CAPS in this study, that have an excess of zeroes in addition to being positively skewed. Adjusting for the baseline CAPS score, trauma exposure, and other relevant covariates, we found baseline plasma CRP concentration to be a highly significant overall predictor of postdeployment CAPS scores (P = .002): each 10-fold increment in CRP concentration was associated with an odds ratio of nonzero outcome (presence vs absence of any PTSD symptoms) of 1.51 (95% CI, 1.15-1.97; P = .003) and a fold increase in outcome with a nonzero value (extent of symptoms when present) of 1.06 (95% CI, 0.99-1.14; P = .09).
   CONCLUSIONS AND RELEVANCE A marker of peripheral inflammation, plasma CRP may be prospectively associated with PTSD symptom emergence, suggesting that inflammation may predispose to PTSD.
C1 [Eraly, Satish A.; Biswas, Nilima; O'Connor, Daniel T.] Univ Calif San Diego, Dept Med, San Diego, CA 92103 USA.
   [Eraly, Satish A.; Nievergelt, Caroline M.; O'Connor, Daniel T.; Baker, Dewleen G.] Vet Affairs VA San Diego Healthcare Syst, San Diego, CA USA.
   [Nievergelt, Caroline M.; Baker, Dewleen G.] VA Ctr Excellence Stress & Mental Hlth, San Diego, CA USA.
   [Nievergelt, Caroline M.; Maihofer, Adam X.; Baker, Dewleen G.] UCSD, Dept Psychiat, La Jolla, CA USA.
   [Barkauskas, Donald A.] Univ So Calif, Dept Prevent Med, Los Angeles, CA 90089 USA.
   [Agorastos, Agorastos] Univ Med Ctr Hamburg Eppendorf, Dept Psychiat & Psychotherapy, Hamburg, Germany.
C3 University of California System; University of California San Diego; US
   Department of Veterans Affairs; Veterans Health Administration (VHA); VA
   San Diego Healthcare System; University of California System; University
   of California San Diego; University of Southern California; University
   of Hamburg; University Medical Center Hamburg-Eppendorf
RP Baker, DG (corresponding author), Vet Affairs Ctr Excellence Stress & Mental Hlth, 3350 La Jolla Village Dr,Ste 116A, San Diego, CA 92161 USA.
EM dgbaker@ucsd.edu
RI Barkauskas, Donald/ISA-9806-2023; Baker, Dewleen/O-4957-2019
OI Nievergelt, Caroline/0000-0001-5766-8923; Agorastos,
   Agorastos/0000-0003-4801-4957
FU UCSD Department of Medicine Career Award; National Heart, Lung, and
   Blood Institute [HL094728]; VA Health Service Research and Development
   [SDR 09-0128]; National Institutes of Health [MH093500]; US Marine
   Corps; US Navy Bureau of Medicine and Surgery
FX Dr Eraly was funded by a UCSD Department of Medicine Career Award and by
   National Heart, Lung, and Blood Institute grant HL094728; Drs
   Nievergelt, O'Connor, Baker, and MRS personnel were supported by VA
   Health Service Research and Development Project Number SDR 09-0128,
   National Institutes of Health MH093500, the US Marine Corps, and the US
   Navy Bureau of Medicine and Surgery.
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NR 81
TC 281
Z9 307
U1 1
U2 44
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 2168-622X
EI 2168-6238
J9 JAMA PSYCHIAT
JI JAMA Psychiatry
PD APR
PY 2014
VL 71
IS 4
BP 423
EP 431
DI 10.1001/jamapsychiatry.2013.4374
PG 9
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA AH2BU
UT WOS:000335926500013
PM 24576974
OA Green Accepted, Green Published
DA 2025-06-11
ER

PT J
AU Jonasson, JM
   Hendryx, M
   Manson, JE
   Dinh, P
   Garcia, L
   Liu, SM
   Luo, JH
AF Miao Jonasson, Junmei
   Hendryx, Michael
   Manson, JoAnn E.
   Dinh, Paul
   Garcia, Lorena
   Liu, Simin
   Luo, Juhua
TI Personality traits and the risk of coronary heart disease or stroke in
   women with diabetes - an epidemiological study based on the Women's
   Health Initiative
SO MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY
LA English
DT Article
DE Coronary heart disease; Epidemiology; Personality traits; Stroke; Type 2
   diabetes
ID METABOLIC SYNDROME; LINE CHARACTERISTICS; TREATMENT ADHERENCE;
   HOSTILITY; ASSOCIATION; OPTIMISM; STRESS; ANGER; COMPLICATIONS;
   DEPRESSION
AB Objective: We studied the associations between personality traits and the risk of coronary heart disease (CHD) or stroke in women with diabetes. Methods: From the Women's Health Initiative, 15,029 women aged 50 to 79 years at enrollment and with self-reported treated diabetes at baseline or follow-up, were followed for a mean of 10 years. Personality traits measured from validated scales included hostility, optimism, ambivalence over emotional expressiveness, and negative emotional expressiveness. Multivariable Cox proportional-hazards regression models were used to examine associations between personality traits and the risk of adjudicated CHD (nonfatal myocardial infarction and CHD death) or stroke outcomes. Progressively adjusted regression approach was used in the multivariable models to adjust for demographics, depression, anthropometric variables, and lifestyle factors. Results: A total of 1,118 incident CHD and 710 incident stroke cases were observed. Women in the highest quartile of hostility had 22% (hazard ratio [HR] 1.22, 95% confidence interval [CI] 1.01-1.48) increased risk for CHD compared with women in the lowest quartile of hostility. P values for trend were greater than 0.05. Stratified analysis by prevalent or incident diabetes showed that the highest quartile of hostility had 34% increased risk for CHD (HR 1.34, 95% CI 1.03-1.74) among women with incident diabetes. Other personality traits were not significantly associated with stroke or CHD. Conclusions: Hostility was associated with incidence of CHD among postmenopausal women with diabetes, especially among incident diabetes. These results provide a basis for targeted prevention programs for women with a high level of hostility and diabetes.
C1 [Miao Jonasson, Junmei] Univ Gothenburg, Sahlgrenska Acad, Inst Med, Dept Publ Hlth & Community Med, Gothenburg, Sweden.
   [Hendryx, Michael] Indiana Univ, Sch Publ Hlth, Dept Environm & Occupat Hlth, Bloomington, IN USA.
   [Manson, JoAnn E.] Harvard Med Sch, Brigham & Womens Hosp, Div Prevent Med, Boston, MA 02115 USA.
   [Dinh, Paul; Luo, Juhua] Indiana Univ, Dept Epidemiol & Biostat, Sch Publ Hlth, Bloomington, IN USA.
   [Garcia, Lorena] Univ Calif Davis, Sch Med, Dept Publ Hlth Sci, Davis, CA 95616 USA.
   [Liu, Simin] Brown Univ, Sch Publ Hlth, Providence, RI 02912 USA.
C3 University of Gothenburg; Indiana University System; Indiana University
   Bloomington; Harvard University; Harvard University Medical Affiliates;
   Brigham & Women's Hospital; Harvard Medical School; Indiana University
   System; Indiana University Bloomington; University of California System;
   University of California Davis; Brown University
RP Jonasson, JM (corresponding author), Univ Gothenburg, Sahlgrenska Acad, Inst Med, Dept Publ Hlth & Community Med, Gothenburg, Sweden.
EM junmei.jonasson@gu.se
RI Miao Jonasson, Junmei/MIN-9869-2025; Manson, JoAnn/JOZ-3576-2023; Liu,
   Simin/I-3689-2014; Dinh, Paul/HTR-1669-2023
OI Liu, Simin/0000-0003-2098-3844; luo, juhua/0000-0002-8901-4462; Dinh,
   Paul/0000-0003-0235-8519
FU National Heart, Lung, and Blood Institute, National Institutes of
   Health, US Department of Health and Human Services [HHSN268201600018C,
   HHSN268201600001C, HHSN268201600002C, HHSN268201600003C,
   HHSN268201600004C]
FX The WHI program is funded by the National Heart, Lung, and Blood
   Institute, National Institutes of Health, US Department of Health and
   Human Services through contracts HHSN268201600018C, HHSN268201600001C,
   HHSN268201600002C, HHSN268201600003C, and HHSN268201600004C.
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NR 41
TC 7
Z9 8
U1 0
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1072-3714
EI 1530-0374
J9 MENOPAUSE
JI Menopause-J. N. Am. Menopause Soc.
PD OCT
PY 2019
VL 26
IS 10
BP 1117
EP 1124
DI 10.1097/GME.0000000000001382
PG 8
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Obstetrics & Gynecology
GA KC0FJ
UT WOS:000506862200007
PM 31479031
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Hung, YJ
   Hsieh, CH
   Chen, YJ
   Pei, D
   Kuo, SW
   Shen, DC
   Sheu, WHH
   Chen, YC
AF Hung, Yi-Jen
   Hsieh, Chang-Hsun
   Chen, Yu-Jun
   Pei, Dee
   Kuo, Shi-Wen
   Shen, Der-Chung
   Sheu, Wayne Huey-Herng
   Chen, Yi-Chyan
TI Insulin sensitivity, proinflammatory markers and adiponectin in young
   males with different subtypes of depressive disorder
SO CLINICAL ENDOCRINOLOGY
LA English
DT Article
ID METABOLIC SYNDROME; GLUCOSE-TOLERANCE; MAJOR DEPRESSION; INFLAMMATORY
   MARKERS; DIABETES-MELLITUS; RATING-SCALE; RESISTANCE; TYPE-2; RISK;
   ASSOCIATION
AB Objective This study was designed to evaluate insulin sensitivity, proinflammatory markers and adiponectin concentration in young males with different subtypes of depressive disorder.
   Methods Nonobese young males with depressive disorder (ages between 18 years and 30 years; body mass index, BMI <= 25 kg/m(2)) were recruited and divided into reactive depression (RD, N = 14), major depression (MD, N = 21) and bipolar depression (BD, N = 15) based on clinical course and symptom changes in Hamilton rating scale for depression (HAM-D). Fourteen age- and BMI-matched healthy males were enrolled as controls. All of the participants received a 75-g oral glucose tolerance test (OGTT). Insulin sensitivity and beta-cell function were calculated by minimal model method from the frequently sampled intravenous glucose tolerance test. Plasma C-reactive protein (CRP), adiponectin, tumour necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) were determined.
   Results Compared to the controls, insulin sensitivity (S(I)) were significantly lower in MD and BD (0.78 +/- 0.09 min(-1)/pmol and 0.75 +/- 0.09 min(-1)/pmol vs. 1.09 +/- 0.08 x 10(-5) min(-1)/pmol, P < 0.05, respectively). Acute insulin response (AIR) to intravenous glucose was elevated in BD as compared to control and RD groups (6079.9 +/- 841.8 pmol vs. 3339.8 +/- 356.4 pmol and 3494.8 +/- 337.7 pmol, P < 0.05, respectively). Plasma adiponectin level was diminished in BD group as compared to the control and RD groups (7.41 +/- 0.45 mu g/ml vs. 9.07 +/- 0.54 mu g/ml and 9.38 +/- 0.46 mu g/ml; P < 0.05 and P < 0.01, respectively). By regression analysis, a significantly negative correlation between HAM-D score and S(I) was found in MD (r = -0.60, P = 0.005) and BD groups (r = -0.57, P = 0.04).
   Conclusions The results suggest that there is an inverse relationship between both major and bipolar depression and insulin resistance in nonobese young males.
C1 Tri Serv Gen Hosp, Natl Def Med Ctr, Dept Psychiat, Taipei 114, Taiwan.
   Tri Serv Gen Hosp, Natl Def Med Ctr, Div Endocrinol & Metab, Taipei, Taiwan.
   Buddhist Tzu Chi Gen Hosp, Div Endocrinol & Metab, Hualien, Taiwan.
   Chung Shan Hosp, Dept Internal Med, Taipei, Taiwan.
   Taichung Vet Gen Hosp, Dept Endocrinol & Metab, Taichung, Taiwan.
C3 Tri-Service General Hospital; National Defense Medical Center;
   Tri-Service General Hospital; National Defense Medical Center; Buddhist
   Tzu Chi General Hospital; Hualien Tzu Chi Hospital; Taichung Veterans
   General Hospital
RP Chen, YC (corresponding author), Tri Serv Gen Hosp, Natl Def Med Ctr, Dept Psychiat, 325 Sec 2 Cheng Kung Rd,Nei Hu Area, Taipei 114, Taiwan.
EM yichyanc@ndmctsgh.edu.tw
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NR 38
TC 64
Z9 72
U1 0
U2 7
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0300-0664
J9 CLIN ENDOCRINOL
JI Clin. Endocrinol.
PD NOV
PY 2007
VL 67
IS 5
BP 784
EP 789
DI 10.1111/j.1365-2265.2007.02963.x
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 221UO
UT WOS:000250253000023
PM 17697007
DA 2025-06-11
ER

PT J
AU Oei, NYL
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   Slagboom, PE
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AF Oei, Nicole Y. L.
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   Veer, Ilya M.
   Slagboom, P. Eline
   van de Grond, Jeroen
   van Heemst, Diana
TI Stress evokes stronger medial posterior cingulate deactivations during
   emotional distraction in slower paced aging
SO BIOLOGICAL PSYCHOLOGY
LA English
DT Article
DE Cortisol; Social stress; Aging; Emotional distraction; Medial posterior
   cingulate cortex; Familial longevity; HPA-axis
ID DOWN SUPPRESSION DEFICIT; AGE-RELATED DIFFERENCES; DEFAULT NETWORK;
   NONAGENARIAN SIBLINGS; METABOLIC SYNDROME; SALIVARY CORTISOL;
   WORKING-MEMORY; INTERFERENCE; ROBUST; OPTIMIZATION
AB Introduction: Middle-aged offspring from long-lived families are thought to have a slower pace of aging, possibly related to HPA-axis function. Here, we investigated the neural and behavioral effects of social stress in offspring compared to their regular aging partners on emotional distraction during working memory (WM).
   Methods: 104 middle-aged participants (53 males) consisting of offspring and their partners underwent the Trier Social Stress Test or a control procedure. Hereafter, a WM task with emotional distracters was performed using fMRI. Saliva cortisol levels were obtained during the procedure.
   Results: Partners had higher overall cortisol levels than offspring. In addition, partners had decreased deactivations compared to offspring in the medial posterior cingulate cortex (mPCC) during emotional distraction, which were significantly correlated with lower accuracy during emotional distraction.
   Discussion: mPCC-deactivations are known to be modulated by chronological aging, with more deactivations in the young than in the old. Here we show the same pattern in familial longevity versus regular aging after mild stress, with more deactivations related to better accuracy during emotional distraction. Functional mPCC deactivations might thus be related to pace of aging, and can be revealed by inducing mild stress.
C1 [Oei, Nicole Y. L.] Univ Amsterdam, Inst Psychol, Dept Dev Psychol, ADAPT Lab, Amsterdam, Netherlands.
   [Oei, Nicole Y. L.] Univ Amsterdam, Amsterdam Brain & Cognit, Amsterdam, Netherlands.
   [Jansen, Steffy W.; van Heemst, Diana] Leiden Univ, Med Ctr, Dept Internal Med, Sect Gerontol & Geriatr, Leiden, Netherlands.
   [Veer, Ilya M.] Charite Univ Med Berlin, Div Mind & Brain Res, Dept Psychiat & Psychotherapy CCM, Berlin, Germany.
   [Veer, Ilya M.] Free Univ Berlin, Berlin, Germany.
   [Veer, Ilya M.] Humboldt Univ, Berlin, Germany.
   [Veer, Ilya M.] Berlin Inst Hlth, Berlin, Germany.
   [Slagboom, P. Eline] Leiden Univ, Med Ctr, Sect Mol Epidemiol, Dept Med Stat & Bioinformat, Leiden, Netherlands.
   [van de Grond, Jeroen] Leiden Univ, Med Ctr, Dept Radiol, Leiden, Netherlands.
C3 University of Amsterdam; University of Amsterdam; Leiden University;
   Leiden University Medical Center (LUMC); Leiden University - Excl LUMC;
   Berlin Institute of Health; Free University of Berlin; Humboldt
   University of Berlin; Charite Universitatsmedizin Berlin; Free
   University of Berlin; Humboldt University of Berlin; Berlin Institute of
   Health; Leiden University; Leiden University Medical Center (LUMC);
   Leiden University - Excl LUMC; Leiden University - Excl LUMC; Leiden
   University; Leiden University Medical Center (LUMC)
RP Oei, NYL (corresponding author), Nieuwe Achtergracht 129B, NL-1018 WS Amsterdam, Netherlands.
EM N.Y.L.Oei@uva.nl
RI Slagboom, P./R-4790-2016; Oei, Nicole/T-1219-2019
FU European Commission project Switchbox (FP7) [Health-F2-2010-2597772];
   Amsterdam Brain and Cognition (University of Amsterdam)
FX This project was financially supported by the European Commission
   project Switchbox (FP7, Health-F2-2010-2597772). N.O. was funded by a
   project grant from Amsterdam Brain and Cognition (University of
   Amsterdam).
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NR 72
TC 6
Z9 6
U1 0
U2 8
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0301-0511
EI 1873-6246
J9 BIOL PSYCHOL
JI Biol. Psychol.
PD MAY
PY 2018
VL 135
BP 84
EP 92
DI 10.1016/j.biopsycho.2018.02.018
PG 9
WC Psychology, Biological; Behavioral Sciences; Psychology; Psychology,
   Experimental
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Behavioral Sciences
GA GK8KN
UT WOS:000436471500009
PM 29505812
OA Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Rodríguez, V
   Rivoira, M
   Guizzardi, S
   de Talamoni, NT
AF Rodriguez, V.
   Rivoira, M.
   Guizzardi, S.
   de Talamoni, N. Tolosa
TI Naringin prevents the inhibition of intestinal Ca<SUP>2+</SUP>
   absorption induced by a fructose rich diet
SO ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
LA English
DT Article
DE Fructose rich diet; Naringin; Intestinal Ca2+ absorption; Oxidative
   stress; Inflammation; Nitrosative stress
ID OXIDATIVE STRESS; CALCIUM-ABSORPTION; INSULIN-RESISTANCE; METABOLIC
   SYNDROME; FED RATS; KAPPA-B; INFLAMMATION; ACTIVATION; EXPRESSION;
   FLAVONOIDS
AB This study tries to elucidate the mechanisms by which fructose rich diets (FRI)) inhibit the rat intestinal Ca2+ absorption, and determine if any or all underlying alterations are prevented by naringin (NAR). Male rats were divided into: 1) controls, 2) treated with FRD, 3) treated with FRD and NAR. The intestinal Ca2+ absorption and proteins of the transcellular and paracellular Ca2+ pathways were measured. Oxidative/nitrosative stress and inflammation parameters were evaluated. FRD rats showed inhibition of the intestinal Ca2+ absorption and decrease in the protein expression of molecules of both Ca2+ pathways, which were blocked by NAR. FRD rats showed an increase in the superoxide anion, a decrease in the glutathione and in the enzymatic activities of the antioxidant system, as well as an increase in the NO content and in the nitrotyrosine content of proteins. They also exhibited an increase in both IL-6 and nuclear NF-kappa B. All these changes were prevented by NAR. In conclusion, FRD inhibit both pathways of the intestinal Ca2+ absorption due to the oxidative/nitrosative stress and inflammation. Since NAR prevents the oxidative/nitrosative stress and inflammation, it might be a drug to avoid alteration in the intestinal Ca2+ absorption caused by FRD.
C1 [Rodriguez, V.; Rivoira, M.; Guizzardi, S.; de Talamoni, N. Tolosa] Univ Nacl Cordoba, INICSA, Fac Ciencias Med, Lab Dr Canas Catedra Bioquim & Biol Mol,CONICET, Cordoba, Argentina.
C3 National University of Cordoba; Consejo Nacional de Investigaciones
   Cientificas y Tecnicas (CONICET)
RP de Talamoni, NT (corresponding author), Univ Nacl Cordoba, Catedra Bioquim & Biol Mol, Fac Ciencias Med, Pabellon Argentina,2do Piso,Ciudad Univ, RA-5000 Cordoba, Argentina.
EM ntolosatalamoni@yahoo.com.ar
OI Rivoira, Maria Angelica/0000-0002-7316-1564
FU FonCyT [PICT 2015-386]; Ministerio de Ciencia de la Provincia de Cordoba
   (GRFT); CONICET (PIP); SECYT (UNC), Argentina; CONICET fellowship
FX This work was supported by Grants from FonCyT (PICT 2015-386),
   Ministerio de Ciencia de la Provincia de Cordoba (GRFT-2015), CONICET
   (PIP 2013-2015) and SECYT (UNC 2016-2017), Argentina. Special thanks
   from the authors to GEPSA (Grupo Pilar S.A.) and the Fundacion de la
   Facultad de Ciencias Medicas for donation of the animal feeding. Prof.
   Dr. Non Tolosa de Talamoni and Dr. Valeria Rodriguez are Members of
   Investigator Career from the Consejo Nacional de Investigaciones
   Cientificas y Tecnologicas (CONICET). Solangue Guizzardi is the
   recipient of a CONICET fellowship. All of the authors participated in
   the conception, design, and performance of the study as well as
   interpretation of data and drafting the manuscript. None of the authors
   had a personal conflict of interest associated with this work.
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NR 55
TC 10
Z9 10
U1 0
U2 11
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0003-9861
EI 1096-0384
J9 ARCH BIOCHEM BIOPHYS
JI Arch. Biochem. Biophys.
PD DEC 15
PY 2017
VL 636
BP 1
EP 10
DI 10.1016/j.abb.2017.11.002
PG 10
WC Biochemistry & Molecular Biology; Biophysics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics
GA FQ1HL
UT WOS:000418107500001
PM 29122589
OA Green Published
DA 2025-06-11
ER

PT J
AU Yong, J
   Johnson, JD
   Arvan, P
   Han, J
   Kaufman, RJ
AF Yong, Jing
   Johnson, James D.
   Arvan, Peter
   Han, Jaeseok
   Kaufman, Randal J.
TI Therapeutic opportunities for pancreatic β-cell ER stress in diabetes
   mellitus
SO NATURE REVIEWS ENDOCRINOLOGY
LA English
DT Review
ID ENDOPLASMIC-RETICULUM STRESS; UNFOLDED PROTEIN RESPONSE;
   THIOREDOXIN-INTERACTING PROTEIN; ELEVATED GLUCOSE-LEVELS; FREE CA2+
   CONCENTRATION; INITIATION-FACTOR 2; HIGH-FAT-DIET; OXIDATIVE STRESS;
   INSULIN-RESISTANCE; TRANSMEMBRANE PROTEIN
AB Diabetes mellitus is characterized by the failure of insulin-secreting pancreatic beta-cells (or beta-cell death) due to either autoimmunity (type 1 diabetes mellitus) or failure to compensate for insulin resistance (type 2 diabetes mellitus; T2DM). In addition, mutations of critical genes cause monogenic diabetes. The endoplasmic reticulum (ER) is the primary site for proinsulin folding; therefore, ER proteostasis is crucial for both beta-cell function and survival under physiological and pathophysiological challenges. Importantly, the ER is also the major intracellular Ca2+ storage organelle, generating Ca2+ signals that contribute to insulin secretion. ER stress is associated with the pathogenesis of diabetes mellitus. In this Review, we summarize the mutations in monogenic diabetes that play causal roles in promoting ER stress in beta-cells. Furthermore, we discuss the possible mechanisms responsible for ER proteostasis imbalance with a focus on T2DM, in which both genetics and environment are considered important in promoting ER stress in beta-cells. We also suggest that controlled insulin secretion from beta-cells might reduce the progression of a key aspect of the metabolic syndrome, namely nonalcoholic fatty liver disease. Finally, we evaluate potential therapeutic approaches to treat T2DM, including the optimization and protection of functional beta-cell mass in individuals with T2DM.
C1 [Yong, Jing; Kaufman, Randal J.] Sanford Burnham Prebys Med Discovery Inst, Degenerat Dis Program, La Jolla, CA 92037 USA.
   [Johnson, James D.] Univ British Columbia, Dept Cellular & Physiol Sci, Vancouver, BC, Canada.
   [Johnson, James D.] Univ British Columbia, Life Sci Inst, Vancouver, BC, Canada.
   [Arvan, Peter] Univ Michigan, Med Ctr, Div Metab Endocrinol & Diabet, Ann Arbor, MI USA.
   [Han, Jaeseok] Soonchunhyang Univ, Soonchunhyang Inst Medi Biosci SIMS, Cheonan Si, Choongchungnam, South Korea.
C3 Sanford Burnham Prebys Medical Discovery Institute; University of
   British Columbia; University of British Columbia; University of Michigan
   System; University of Michigan; Soonchunhyang University
RP Kaufman, RJ (corresponding author), Sanford Burnham Prebys Med Discovery Inst, Degenerat Dis Program, La Jolla, CA 92037 USA.; Han, J (corresponding author), Soonchunhyang Univ, Soonchunhyang Inst Medi Biosci SIMS, Cheonan Si, Choongchungnam, South Korea.
EM hanjs015@sch.ac.kr; rkaufman@sbpdiscovery.org
RI Johnson, James/B-3919-2008; Kaufman, Randal/LGY-4753-2024; Yong,
   Jing/I-2150-2012
OI Johnson, James/0000-0002-7523-9433
FU NIH [CA198103, DK113171, DK110973, DK103185, DK48280]; National Research
   Foundation of Korea [NRF-2017M3A9G7072745, NRF2019R1A5A8083404,
   NRF-2017M3A9C6033069, NRF2019R1A2C1085284]; Diabetes Investigator Award
   from Diabetes Canada; National Institute of Diabetes and Digestive and
   Kidney Diseases [R01DK048280] Funding Source: NIH RePORTER
FX The authors acknowledge the support of NIH grants CA198103, DK113171,
   DK110973, DK103185 (R.J.K.) and DK48280 (P. A.), and the National
   Research Foundation of Korea NRF-2017M3A9G7072745, NRF2019R1A5A8083404,
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NR 154
TC 149
Z9 162
U1 14
U2 72
PU NATURE RESEARCH
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 1759-5029
EI 1759-5037
J9 NAT REV ENDOCRINOL
JI Nat. Rev. Endocrinol.
PD AUG
PY 2021
VL 17
IS 8
BP 455
EP 467
DI 10.1038/s41574-021-00510-4
EA JUN 2021
PG 13
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA TJ0UB
UT WOS:000664829300001
PM 34163039
OA Green Accepted
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Utge, SJ
   Soronen, P
   Loukola, A
   Kronholm, E
   Ollila, HM
   Pirkola, S
   Porkka-Heiskanen, T
   Partonen, T
   Paunio, T
AF Utge, Siddheshwar J.
   Soronen, Pia
   Loukola, Anu
   Kronholm, Erkki
   Ollila, Hanna M.
   Pirkola, Sami
   Porkka-Heiskanen, Tarja
   Partonen, Timo
   Paunio, Tiina
TI Systematic Analysis of Circadian Genes in a Population-Based Sample
   Reveals Association of TIMELESS with Depression and Sleep
   Disturbance
SO PLOS ONE
LA English
DT Article
ID BIPOLAR-I-DISORDER; CLOCK GENE; DIURNAL PREFERENCE; PHASE SYNDROME;
   METABOLIC SYNDROME; SUPRACHIASMATIC NUCLEUS; TRANSCRIPTION FACTOR;
   LINKAGE ANALYSES; MOOD DISORDERS; POLYMORPHISM
AB Disturbances in the circadian pacemaker system are commonly found in individuals with depression and sleep-related problems. We hypothesized that some of the canonical circadian clock genes would be associated with depression accompanied by signs of disturbed sleep, early morning awakening, or daytime fatigue. We tested this hypothesis in a population-based sample of the Health 2000 dataset from Finland, including 384 depressed individuals and 1270 controls, all with detailed information on sleep and daytime vigilance, and analyzed this set of individuals with regard to 113 single-nucleotide polymorphisms of 18 genes of the circadian system. We found significant association between TIMELESS variants and depression with fatigue (D+FAT+) (rs7486220: pointwise P = 0.000099, OR = 1.66; corrected empirical P for the model of D+FAT+ = 0.0056; haplotype 'C-A-A-C' of rs2291739-rs2291738-rs7486220-rs1082214: P = 0.0000075, OR = 1.72) in females, and association to depression with early morning awakening (D+EMA+) (rs1082214: pointwise P = 0.0009, OR = 2.70; corrected empirical P = 0.0374 for the model D+EMA+; haplotype 'G-T' of rs7486220 and rs1082214: P = 0.0001, OR = 3.01) in males. There was significant interaction of gender and TIMELESS (for example with rs1082214, P = 0.000023 to D+EMA+ and P = 0.005 to D+FAT+). We obtained supported evidence for involvement of TIMELESS in sleeping problems in an independent set of control individuals with seasonal changes in mood, sleep duration, energy level and social activity in females (P = 0.036, (R) = 0.123 for rs1082214) and with early morning awakening or fatigue in males (P = 0.038 and P = 0.0016, respectively, for rs1082214). There was also some evidence of interaction between TIMELESS and PER1 in females to D+FAT+ as well as between TIMELESS and ARNTL, RORA or NR1D1 in males to D+EMA+. These findings support a connection between circadian genes and gender-dependent depression and defective sleep regulation.
C1 [Utge, Siddheshwar J.; Soronen, Pia; Loukola, Anu; Ollila, Hanna M.; Paunio, Tiina] Natl Inst Hlth & Welf, Publ Hlth Genom Unit, Helsinki, Finland.
   [Utge, Siddheshwar J.; Ollila, Hanna M.; Porkka-Heiskanen, Tarja] Univ Helsinki, Dept Physiol, Helsinki, Finland.
   [Utge, Siddheshwar J.; Soronen, Pia; Pirkola, Sami; Paunio, Tiina] Univ Helsinki, Cent Hosp, Dept Psychiat, Helsinki, Finland.
   [Utge, Siddheshwar J.; Soronen, Pia; Loukola, Anu; Ollila, Hanna M.; Paunio, Tiina] Univ Helsinki, FIMM, Helsinki, Finland.
   [Kronholm, Erkki] Natl Inst Hlth & Welf, Dept Chron Dis Prevent, Populat Studies Unit, Turku, Finland.
   [Pirkola, Sami; Partonen, Timo] Natl Inst Hlth & Welf, Dept Mental Hlth & Subst Abuse Serv, Helsinki, Finland.
C3 Finland National Institute for Health & Welfare; University of Helsinki;
   University of Helsinki; Helsinki University Central Hospital; University
   of Helsinki; Finland National Institute for Health & Welfare; Finland
   National Institute for Health & Welfare
RP Utge, SJ (corresponding author), Natl Inst Hlth & Welf, Publ Hlth Genom Unit, Helsinki, Finland.
EM Tiina.Paunio@thl.fi
RI ; Partonen, Timo/G-1105-2012; Ollila, Hanna/I-8552-2017
OI Pirkola, Sami/0000-0003-0138-3130; Partonen, Timo/0000-0003-1951-2455;
   Ollila, Hanna/0000-0002-5302-6429; Stenberg, Tarja/0000-0003-1843-7625;
   Loukola, Anu-Maria/0000-0003-0542-5967
FU European Union [LSHM-CT-2005-518189, MCRTN-CT-2004-512362]; Centre for
   International Mobility [CIMO, TM-09-6095]; Helsinki University Central
   Hospital [EVO, TYH6254]; Academy of Finland post-doctoral research
   fellowship
FX This study was supported by grants from the European Union
   (LSHM-CT-2005-518189 and MCRTN-CT-2004-512362), Centre for International
   Mobility (CIMO, TM-09-6095), and Helsinki University Central Hospital
   (EVO, TYH6254), and this support is gratefully acknowledged. Dr. Anu
   Loukola and Dr. Timo Partonen were supported by an Academy of Finland
   post-doctoral research fellowship. The funders had no role in study
   design, data collection and analysis, decision to publish, or
   preparation of the manuscript.
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NR 89
TC 82
Z9 91
U1 1
U2 14
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD FEB 18
PY 2010
VL 5
IS 2
AR e9259
DI 10.1371/journal.pone.0009259
PG 13
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 557FJ
UT WOS:000274654700011
PM 20174623
OA Green Submitted, gold, Green Published
DA 2025-06-11
ER

PT J
AU Wei, J
   Zeng, C
   Gong, QY
   Li, XX
   Lei, GH
   Yang, TB
AF Wei, Jie
   Zeng, Chao
   Gong, Qian-yi
   Li, Xiao-xiao
   Lei, Guang-hua
   Yang, Tu-bao
TI Associations between Dietary Antioxidant Intake and Metabolic Syndrome
SO PLOS ONE
LA English
DT Article
ID HEALTHY-YOUNG ADULTS; SELENIUM INTAKE; CARDIOVASCULAR-DISEASE; OXIDATIVE
   STRESS; SERUM; RISK; PREVALENCE; POPULATION; ADIPOSITY; CHINA
AB Background
   The objective of this study was to evaluate the association between dietary antioxidant intake (carotenoid, vitamin C, E and selenium) intake and metabolic syndrome (MS).
   Method
   This cross-sectional study included 2069 subjects undergoing a regular health checkup. Biochemical test results and data on dietary intakes were collected for analysis. Adjustment for energy intake and multi-variable logistic regression were performed to determine adjusted odds ratios (ORs) and corresponding 95% confidence intervals (95% CI) for the relationship between dietary antioxidants intake and MS. The lowest quartile of antioxidant intake was regarded as the reference category.
   Result
   Dietary vitamin C intake (P values for trend were 0.02 in energy adjusted analysis and 0.08 in multivariable adjusted analysis) had a negative association with MS, as did selenium intake in the second quartile (energy adjusted OR: 0.60, 95% CI: 0.43 to 0.85; multivariable adjusted OR: 0.60, 95% CI: 0.43 to 0.86). However, there was no significant relationship between dietary carotenoid and vitamin E intake and MS.
   Conclusion
   Subjects with low intake of vitamin C might be predisposed to development of MS, while dietary selenium intake had a moderate negative association with MS. Dietary carotenoid and vitamin E intake was not associated with MS.
C1 [Wei, Jie; Gong, Qian-yi; Li, Xiao-xiao; Yang, Tu-bao] Cent S Univ, Dept Epidemiol & Hlth Stat, Sch Publ Hlth, Changsha 410008, Hunan, Peoples R China.
   [Zeng, Chao; Lei, Guang-hua] Cent S Univ, Xiangya Hosp, Dept Orthopaed, Changsha 410008, Hunan, Peoples R China.
C3 Central South University; Central South University
RP Yang, TB (corresponding author), Cent S Univ, Dept Epidemiol & Hlth Stat, Sch Publ Hlth, Changsha 410008, Hunan, Peoples R China.
EM 1064960669@qq.com
RI Wei, Jie/ACR-8087-2022
OI Wei, Jie/0000-0003-3510-8241
FU Hunan Provincial Innovation Foundation for Postgraduate [CX2014B096];
   Fundamental Research Funds for the Central Universities of Central South
   University [2014zzts070]
FX This work was supported by Hunan Provincial Innovation Foundation for
   Postgraduate (CX2014B096), the Fundamental Research Funds for the
   Central Universities of Central South University (2014zzts070). The
   funders had no role in study design, data collection and analysis,
   decision to publish, or preparation of the manuscript.
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NR 36
TC 59
Z9 60
U1 1
U2 15
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JUN 22
PY 2015
VL 10
IS 6
AR e0130876
DI 10.1371/journal.pone.0130876
PG 13
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA CL3FM
UT WOS:000356835800115
PM 26098747
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Rocha, NG
   Sales, ARK
   Penedo, LA
   Pereira, FS
   Silva, MS
   Miranda, RL
   Silva, JFR
   Silva, BM
   Santos, AA
   Nobrega, ACL
AF Rocha, Natalia G.
   Sales, Allan R. K.
   Penedo, Leticia A.
   Pereira, Felipe S.
   Silva, Mayra S.
   Miranda, Renan L.
   Silva, Jemima F. R.
   Silva, Bruno M.
   Santos, Aline A.
   Nobrega, Antonio C. L.
TI Impaired Circulating Angiogenic Cells Mobilization and
   Metalloproteinase-9 Activity after Dynamic Exercise in Early Metabolic
   Syndrome
SO BIOMED RESEARCH INTERNATIONAL
LA English
DT Article
ID ENDOTHELIAL PROGENITOR CELLS; CORONARY-ARTERY-DISEASE; ADHESION
   MOLECULES; CARDIOVASCULAR-DISEASE; INFLAMMATORY MARKERS; OXIDATIVE
   STRESS; E-SELECTIN; RISK; HYPERTENSION; RECRUITMENT
AB Increased levels of adhesion molecules or metalloproteinases (MMPs) may indicate endothelial dysfunction. Exercise mobilizes circulating angiogenic cells (CACs) from bone marrow in healthy subjects, improving vascular function. However, it is unclear whether this mechanism is preserved in the early stages of metabolic syndrome (early MetS). We aimed to evaluate the acute effects of exercise on adhesion molecules, angiogenic factors, MMPs, and CACs in early MetS. Fifteen subjects with early MetS and nine healthy controls underwent an exercise session and a nonexercise session, randomly. Adhesion molecules, angiogenic factors, CACs, and MMPs were evaluated before and after exercise or nonexercise sessions. At baseline, levels of sE-selectin, sICAM-1, and MMP-9 were higher in early MetS than in controls (p <= 0.03). After exercise, sE-selectin, sICAM-1, and MMP-9 levels were still higher in early MetS (p < 0.05). Subjects with early MetS presented less CACs (p = 0.02) and higher MMP-9 activity (p <= 0.04), while healthy controls presented higher MMP-2 activity after exercise. There was no difference between moments in nonexercise session (p > 0.05). In conclusion, subjects with early MetS already presented impaired endothelial function at rest along with a decrease in CACs and an increase in MMP-9 activity in response to exercise.
C1 [Rocha, Natalia G.; Sales, Allan R. K.; Penedo, Leticia A.; Pereira, Felipe S.; Silva, Mayra S.; Miranda, Renan L.; Silva, Jemima F. R.; Santos, Aline A.; Nobrega, Antonio C. L.] Univ Fed Fluminense, Dept Physiol & Pharmacol, Lab Exercise Sci, BR-24210130 Niteroi, RJ, Brazil.
   [Silva, Bruno M.] Univ Fed Sao Paulo, Dept Physiol, Sect Exercise Physiol, BR-04023062 Sao Paulo, SP, Brazil.
C3 Universidade Federal Fluminense; Universidade Federal de Sao Paulo
   (UNIFESP)
RP Nobrega, ACL (corresponding author), Univ Fed Fluminense, Dept Physiol & Pharmacol, Lab Exercise Sci, BR-24210130 Niteroi, RJ, Brazil.
EM anobrega@id.uff.br
RI da Nobrega, Antonio/O-5107-2019; Sales, Allan/ABA-8691-2021; Silva,
   Bruno/F-7781-2010; Rocha, Natalia Galito/AAN-7903-2020
OI Silva, Bruno/0000-0003-0473-3706; Rocha, Natalia
   Galito/0000-0002-1990-9834; Miranda, Renan/0000-0002-3305-3913
FU State of Rio de Janeiro Agency for Research (FAPERJ)
   [E-26/102.378/2009]; National Council of Scientific and Technological
   Development (CNPq) [307251/2009-8]
FX The authors would like to thank Helena Naly Miguens Rocha for technical
   assistance and Tyler Bammert, Collin Beckstrom, and Grace Lincenberg for
   their English review of the paper. This work was supported by the State
   of Rio de Janeiro Agency for Research (FAPERJ, E-26/102.378/2009) and
   the National Council of Scientific and Technological Development (CNPq,
   307251/2009-8).
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NR 44
TC 6
Z9 6
U1 0
U2 4
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2314-6133
EI 2314-6141
J9 BIOMED RES INT
JI Biomed Res. Int.
PY 2015
VL 2015
AR 920356
DI 10.1155/2015/920356
PG 9
WC Biotechnology & Applied Microbiology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Research & Experimental Medicine
GA CV2LH
UT WOS:000364087600001
PM 26557715
OA Green Submitted, Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Ros, E
AF Ros, Emilio
TI Health Benefits of Nut Consumption
SO NUTRIENTS
LA English
DT Review
DE tree nuts; peanuts; fatty acids; antioxidants; cholesterol;
   cardiovascular disease; diabetes; inflammation
ID CORONARY-HEART-DISEASE; CARDIOVASCULAR RISK-FACTORS; ENDOTHELIAL
   FUNCTION; LONG-TERM; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   BODY-WEIGHT; TREE NUTS; WALNUT CONSUMPTION; PEANUT CONSUMPTION
AB Nuts (tree nuts and peanuts) are nutrient dense foods with complex matrices rich in unsaturated fatty and other bioactive compounds: high-quality vegetable protein, fiber, minerals, tocopherols, phytosterols, and phenolic compounds. By virtue of their unique composition, nuts are likely to beneficially impact health outcomes. Epidemiologic studies have associated nut consumption with a reduced incidence of coronary heart disease and gallstones in both genders and diabetes in women. Limited evidence also suggests beneficial effects on hypertension, cancer, and inflammation. Interventional studies consistently show that nut intake has a cholesterol-lowering effect, even in the context of healthy diets, and there is emerging evidence of beneficial effects on oxidative stress, inflammation, and vascular reactivity. Blood pressure, visceral adiposity and the metabolic syndrome also appear to be positively influenced by nut consumption. Thus it is clear that nuts have a beneficial impact on many cardiovascular risk factors. Contrary to expectations, epidemiologic studies and clinical trials suggest that regular nut consumption is unlikely to contribute to obesity and may even help in weight loss. Safety concerns are limited to the infrequent occurrence of nut allergy in children. In conclusion, nuts are nutrient rich foods with wide-ranging cardiovascular and metabolic benefits, which can be readily incorporated into healthy diets.
C1 [Ros, Emilio] Hosp Clin Barcelona, Lipid Clin, Endocrinol & Nutr Serv, Inst Invest Biomed August Pii Sunyer, Barcelona, Spain.
C3 University of Barcelona; Hospital Clinic de Barcelona; IDIBAPS
RP Ros, E (corresponding author), Hosp Clin Barcelona, Lipid Clin, Endocrinol & Nutr Serv, Inst Invest Biomed August Pii Sunyer, Barcelona, Spain.
EM eros@clinic.ub.es
OI Ros, Emilio/0000-0002-2573-1294
FU Spanish Health Ministry (FIS Thematic Research Networks) [C03/01,
   G03/140]; California Walnut Commission, Sacramento, CA
FX Work supported in part by grants from the Spanish Health Ministry (FIS
   Thematic Research Networks C03/01 and G03/140) and the California Walnut
   Commission, Sacramento, CA. CIBERobn is an initiative of ISCIII, Spain.
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NR 150
TC 568
Z9 607
U1 5
U2 183
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JUL
PY 2010
VL 2
IS 7
BP 652
EP 682
DI 10.3390/nu2070652
PG 31
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 864JS
UT WOS:000298236900001
PM 22254047
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Yao, GP
   Wang, ZW
   Xie, R
   Zhanghuang, CH
   Yan, B
AF Yao, Guiping
   Wang, Zhiwei
   Xie, Rui
   Zhanghuang, Chenghao
   Yan, Bing
TI Trace element zinc metabolism and its relation to tumors
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Review
DE zinc; zinc metabolism; metabolic syndrome; cancer therapy; controversy
ID IMMUNE FUNCTION; CANCER; SUPPLEMENTATION; GENE; TRANSPORTERS;
   RESISTANCE; SURVIVAL; HEALTH; FAMILY; COPPER
AB Zinc is an essential trace element in the human body, playing a crucial role in cellular metabolism.Dysregulation of zinc homeostasis can lead to abnormal cellular metabolism, contributing to diseases and closely related to tumor development. Adequate zinc intake can maintain zinc homeostasis in the body and support normal cellular metabolism. This review discusses the metabolic processes of zinc in the human body and its close relationship with tumorigenesis. It briefly describes zinc absorption, transport, storage, and release, as well as its important role in gene expression, signal transduction, oxidative stress, immune response, and apoptosis. It focuses on the abnormal cellular metabolism caused by excessive or insufficient zinc, the relationship between zinc homeostasis disruption and metabolic syndrome, and the mechanisms involved in tumor development. It analyzes how changes in the expression and activity of zinc transporters may lead to disrupted zinc homeostasis in tumor tissues. It points out that zinc deficiency is associated with various cancers, including prostate cancer, hepatocellular carcinoma, pancreatic cancer, lung cancer, ovarian cancer, esophageal squamous cell carcinoma, and breast cancer. The summary emphasizes that zinc metalloproteins could serve as potential targets for cancer therapy, and regulating the expression and activity of zinc transport proteins may offer new methods and strategies for clinical cancer treatment.
C1 [Yao, Guiping; Wang, Zhiwei; Zhanghuang, Chenghao; Yan, Bing] Kunming Childrens Hosp, Dept Urol, Kunming, Yunnan, Peoples R China.
   [Xie, Rui] Kunming Childrens Hosp, Dept Orthoped, Kunming, Yunnan, Peoples R China.
   [Zhanghuang, Chenghao; Yan, Bing] Kunming Childrens Solid Tumor Diag & Treatment Ctr, Yunnan Prov Clin Res Ctr Childrens Hlth & Dis, Kunming, Yunnan, Peoples R China.
   [Zhanghuang, Chenghao; Yan, Bing] Kunming Childrens Hosp, Yunnan Clin Med Ctr Pediat Dis, Yunnan Key Lab Childrens Major Dis Res, Kunming, Yunnan, Peoples R China.
RP Zhanghuang, CH; Yan, B (corresponding author), Kunming Childrens Hosp, Dept Urol, Kunming, Yunnan, Peoples R China.; Zhanghuang, CH; Yan, B (corresponding author), Kunming Childrens Solid Tumor Diag & Treatment Ctr, Yunnan Prov Clin Res Ctr Childrens Hlth & Dis, Kunming, Yunnan, Peoples R China.; Zhanghuang, CH; Yan, B (corresponding author), Kunming Childrens Hosp, Yunnan Clin Med Ctr Pediat Dis, Yunnan Key Lab Childrens Major Dis Res, Kunming, Yunnan, Peoples R China.
EM 736564145@qq.com; ybwcy@163.com
RI ids, dw/HHN-4570-2022
FU Scientific Research Foundation of Education Department of Yunnan
   Province [2020J0228, 2023J0295]; Kunming Medical University Joint
   Project of Department of Science and Technology of Yunnan Province
   [202301AY070001-108]; Kunming City Health Science and Technology Talent
   "1000" training Project [2020-SW]; Kunming Health Personnel Training
   Project Technology Center Construction Project [2020-SW]; Yunnan
   Province Clinical Research Center for Children's Health and Disease
FX The author(s) declare financial support was received for the research,
   authorship, and/or publication of this article. The study was supported
   by: Scientific Research Foundation of Education Department of Yunnan
   Province (No. 2020J0228, 2023J0295), Kunming Medical University Joint
   Project of Department of Science and Technology of Yunnan Province (No.
   202301AY070001-108); Kunming City Health Science and Technology Talent
   "1000" training Project (No. 2020-SW (Reserve)-112), Kunming Health
   Personnel Training Project Technology Center Construction Project (No.
   2020-SW (Tech) -15) and Yunnan Province Clinical Research Center for
   Children's Health and Disease. The funding bodies played no role in the
   study's design and collection, analysis and interpretation of data, and
   writing the manuscript.
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NR 101
TC 3
Z9 3
U1 14
U2 14
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD DEC 5
PY 2024
VL 15
AR 1457943
DI 10.3389/fendo.2024.1457943
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA Q0D9S
UT WOS:001381513100001
PM 39717098
OA gold
DA 2025-06-11
ER

PT J
AU Redman, LM
   Ravussin, E
AF Redman, Leanne M.
   Ravussin, Eric
TI Caloric Restriction in Humans: Impact on Physiological, Psychological,
   and Behavioral Outcomes
SO ANTIOXIDANTS & REDOX SIGNALING
LA English
DT Review
ID RHESUS-MONKEYS; DEHYDROEPIANDROSTERONE-SULFATE; INSULIN SENSITIVITY;
   DIETARY RESTRICTION; PHYSICAL-ACTIVITY; OXIDATIVE STRESS;
   BODY-COMPOSITION; WEIGHT-LOSS; ENERGY RESTRICTION; METABOLIC SYNDROME
AB The current societal environment is marked by overabundant accessibility of food coupled with a strong trend of reduced physical activity, both leading to the development of a constellation of disorders, including central obesity, insulin resistance, dyslipidemia, and hypertension (metabolic syndrome). Prolonged calorie restriction (CR) has been shown to extend both the median and maximal lifespan in a variety of lower species such as yeast, worms, fish, rats, and mice. Mechanisms of this CR-mediated lifespan extension are not fully elucidated, but possibly involve significant alterations in energy metabolism, oxidative damage, insulin sensitivity, inflammation, and functional changes in both the neuroendocrine and sympathetic nervous systems. Here we review some of the major physiological, psychological, and behavioral changes after 6 months of CR in overweight otherwise healthy volunteers. Special emphasis is given to the first completed clinical studies that have investigated the effects of controlled, high-quality energy-restricted diets on both biomarkers of longevity and on the development of chronic diseases related to age in humans. With the incremental expansion of research endeavors in the area of energy or caloric restriction, data on the effects of CR in animal models and human subjects are becoming more accessible. Antioxid. Redox Signal. 14, 275-287.
C1 [Redman, Leanne M.; Ravussin, Eric] Pennington Biomed Res Ctr, Baton Rouge, LA 70808 USA.
C3 Louisiana State University System; Louisiana State University;
   Pennington Biomedical Research Center
RP Redman, LM (corresponding author), Pennington Biomed Res Ctr, 6400 Perkins Rd, Baton Rouge, LA 70808 USA.
EM leanne.redman@pbrc.edu
RI Redman, Leanne/N-1986-2017; Ravussin, Eric/N-1985-2017
FU NHMRC of Australia [349553]
FX L.M.R. is supported by a Neil Hamilton-Fairley Training Fellowship
   awarded by the NHMRC of Australia (ID 349553). E.R. has initiated
   studies of caloric restriction in nonobese individuals supported by U01
   AG20478.
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NR 109
TC 215
Z9 243
U1 0
U2 51
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1523-0864
EI 1557-7716
J9 ANTIOXID REDOX SIGN
JI Antioxid. Redox Signal.
PD JAN
PY 2011
VL 14
IS 2
BP 275
EP 287
DI 10.1089/ars.2010.3253
PG 13
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 695RR
UT WOS:000285390800009
PM 20518700
OA Green Published
DA 2025-06-11
ER

PT J
AU Villeda-Gonzalez, JD
   Gomez-Olivares, JL
   Baiza-Gutman, LA
AF Villeda-Gonzalez, Juan David
   Gomez-Olivares, Jose Luis
   Baiza-Gutman, Luis Arturo
TI New paradigms in the study of the cholinergic system and metabolic
   diseases: Acetyl-and-butyrylcholinesterase
SO JOURNAL OF CELLULAR PHYSIOLOGY
LA English
DT Article
DE anti-inflammatory cholinergic pathway; cholinesterases; metabolic
   syndrome; obesity
ID GAMMA-GLUTAMYL-TRANSFERASE; ACTIVE-SITE GORGE; OXIDATIVE STRESS; HUMAN
   ACETYLCHOLINESTERASE; ANTIINFLAMMATORY PATHWAY; VAGUS NERVE;
   CHOLINESTERASE; RISK; GLYCOSYLATION; INFLAMMATION
AB Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are enzymes that belong to the neuromuscular cholinergic system, their main function is to hydrolyze the neurotransmitter acetylcholine (ACh), through their hydrolysis these enzymes regulate the neuronal and neuromuscular cholinergic system. They have recently attracted considerable attention due to the discovery of new enzymatic and nonenzymatic functions. These discoveries have aroused the interest of numerous scientists, consolidating the relevance of this group of enzymes. Recent investigations have revealed a positive correlation between several risk factors for metabolic syndrome (MetS) and the expression of cholinesterases (ChE's), which underscore the impact of high ChE's activity on the pro-inflammatory state associated with MetS. In addition, the excessive hydrolysis of ACh and other choline esters (succinylcholine, propionylcholine, butyrylcholine, etc.) by both ChE's results in the overproduction of fatty acid precursor metabolites, which facilitate the synthesis of very low-density lipoproteins and triacylglycerols. Participation in these processes may represent the link between ChE's and metabolic disorders. However, further scientific research is required to fully elucidate the involvement of ChE's in metabolic diseases. This review aims to collect recent research studies that contribute to understanding the association between the cholinergic system and metabolic diseases.
C1 [Villeda-Gonzalez, Juan David] Univ Nacl Autonoma Mexico, Estancia Posdoctoral CONAHCYT, Inst Fisiol Celular, Mexico City, Mexico.
   [Gomez-Olivares, Jose Luis] Univ Autonoma Metropolitana Iztapalapa, Div Ciencias Biol & Salud, Lab Biomembranas, Mexico City, Mexico.
   [Baiza-Gutman, Luis Arturo] Univ Nacl Autonoma Mexico, Fac Estudios Super Iztacala, Unidad Morfol & Func, Lab Biol Desarrollo, Mexico City, Estado De Mexic, Mexico.
   [Villeda-Gonzalez, Juan David] Univ Nacl Autonoma Mexico, Inst Fisiol Celular, Estancia Posdoctoral CONAHCYT, Edificio Neurociencias,Lab AL-102,Ciudad Univ, Mexico City 04510, Mexico.
C3 Universidad Nacional Autonoma de Mexico; Universidad Autonoma
   Metropolitana - Mexico; Universidad Nacional Autonoma de Mexico;
   Universidad Nacional Autonoma de Mexico
RP Villeda-Gonzalez, JD (corresponding author), Univ Nacl Autonoma Mexico, Inst Fisiol Celular, Estancia Posdoctoral CONAHCYT, Edificio Neurociencias,Lab AL-102,Ciudad Univ, Mexico City 04510, Mexico.
EM jvilleda@ifc.unam.mx
RI Baiza-Gutman, Luis/H-9160-2019; Villeda-González, Juan
   David/ITV-3995-2023; /Y-6604-2018
OI /0000-0002-5663-4710; Baiza-Gutman, Luis Arturo/0000-0002-3669-4185;
   Villeda Gonzalez, Juan David/0000-0002-5279-8590
FU CONAHCYT; Universidad Nacional Autonomade Mexico; Direccion General de
   Asuntos del Personal Academico, Universidad NacionalAutonoma de Mexico;
   PAPIIT
FX CONAHCYT; Universidad Nacional Autonomade Mexico; Direccion General de
   Asuntos del Personal Academico, Universidad NacionalAutonoma de Mexico;
   PAPIIT
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NR 107
TC 11
Z9 12
U1 3
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0021-9541
EI 1097-4652
J9 J CELL PHYSIOL
JI J. Cell. Physiol.
PD AUG
PY 2024
VL 239
IS 8
DI 10.1002/jcp.31274
EA APR 2024
PG 17
WC Cell Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Physiology
GA C9R6J
UT WOS:001200414300001
PM 38605655
OA hybrid
DA 2025-06-11
ER

PT J
AU Natt, D
   Ost, A
AF Natt, D.
   Ost, A.
TI Male reproductive health and intergenerational metabolic responses from
   a small RNA perspective
SO JOURNAL OF INTERNAL MEDICINE
LA English
DT Review
DE small RNA; metabolic syndrome; obesity; cell biology; diet;
   reproduction; sperm; infertility; epigenetic inheritance; sperm motility
ID SMALL NONCODING RNAS; HIGH-FAT DIET; GENE-EXPRESSION; MESSENGER-RNA;
   SPERM MATURATION; HUMAN EPIDIDYMIS; TRANSGENERATIONAL INHERITANCE;
   PATERNAL OBESITY; OXIDATIVE STRESS; DNA METHYLATION
AB The world has recently experienced a decline in male reproductive (e.g. sperm counts and motility) and metabolic (e.g. obesity and diabetes) health. Accumulated evidence from animal models also shows that the metabolic health of the father may influence the metabolic health in his offspring. Vectors for such paternal intergenerational metabolic responses (IGMRs) involve small noncoding RNAs (sncRNAs) that often increase in spermatozoa during the last days of maturation in the epididymis. We and others have shown that the metabolic state - depending on factors such as diet, obesity and physical exercise - may affect sperm quality and sperm sncRNA. Together, this suggests that there are overlapping aetiologies between the male metabolic syndrome, male factor infertility and intergenerational responses. In this review, we present a theoretical framework for an overlap of these aetiologies by exploring the advances in our understanding of the roles of sncRNA in spermatogenesis and offspring development. A special focus will lie on novel findings about tRNA-derived small RNA (tsRNA), rRNA-derived small RNA (rsRNA) and small mitochondrial RNA (mitoRNA), and their emerging roles in intergenerational metabolic and reproductive health.
C1 [Natt, D.; Ost, A.] Linkoping Univ, Dept Clin & Expt Med, Linkoping, Sweden.
C3 Linkoping University
RP Ost, A (corresponding author), Linkoping Univ, Dept Biomed & Clin Sci, Cell Biol Bldg,Floor 12, S-58183 Linkoping, Sweden.
EM anita.ost@liu.se
RI Natt, Daniel/AAR-3928-2021
OI Natt, Daniel/0000-0001-9182-9401
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NR 158
TC 32
Z9 34
U1 2
U2 25
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0954-6820
EI 1365-2796
J9 J INTERN MED
JI J. Intern. Med.
PD SEP
PY 2020
VL 288
IS 3
BP 305
EP 320
DI 10.1111/joim.13096
PG 16
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA NA7HS
UT WOS:000559988500005
PM 32415866
OA Bronze
DA 2025-06-11
ER

PT J
AU Caliceti, C
   Calabria, D
   Roda, A
   Cicero, AFG
AF Caliceti, Cristiana
   Calabria, Donato
   Roda, Aldo
   Cicero, Arrigo F. G.
TI Fructose Intake, Serum Uric Acid, and Cardiometabolic Disorders: A
   Critical Review
SO NUTRIENTS
LA English
DT Review
DE fructose; uric acid; cardiometabolic disorders; xanthine oxidase;
   pathophysiology; epidemiology
ID CORONARY-HEART-DISEASE; XANTHINE-OXIDASE INHIBITION; CANCER RESISTANCE
   PROTEIN; SWEETENED SOFT DRINKS; NITRIC-OXIDE; ENDOTHELIAL DYSFUNCTION;
   BLOOD-PRESSURE; CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; OXIDATIVE
   STRESS
AB There is a direct relationship between fructose intake and serum levels of uric acid (UA), which is the final product of purine metabolism. Recent preclinical and clinical evidence suggests that chronic hyperuricemia is an independent risk factor for hypertension, metabolic syndrome, and cardiovascular disease. It is probably also an independent risk factor for chronic kidney disease, Type 2 diabetes, and cognitive decline. These relationships have been observed for high serum UA levels (> 5.5 mg/dL in women and > 6 mg/dL in men), but also for normal to high serum UA levels (5-6 mg/dL). In this regard, blood UA levels are much higher in industrialized countries than in the rest of the world. Xanthine-oxidase inhibitors can reduce UA and seem to minimize its negative effects on vascular health. Other dietary and pathophysiological factors are also related to UA production. However, the role of fructose-derived UA in the pathogenesis of cardiometabolic disorders has not yet been fully clarified. Here, we critically review recent research on the biochemistry of UA production, the relationship between fructose intake and UA production, and how this relationship is linked to cardiometabolic disorders.
C1 [Caliceti, Cristiana; Roda, Aldo] Univ Bologna, Alma Mater Studiorum, Dept Chem Giacomo Ciamician, I-40126 Bologna, Italy.
   [Caliceti, Cristiana; Roda, Aldo] INBB, I-00136 Rome, Italy.
   [Caliceti, Cristiana; Calabria, Donato; Roda, Aldo] Univ Bologna, Alma Mater Studiorum, CIRI EA, I-47900 Rimini, Italy.
   [Cicero, Arrigo F. G.] Univ Bologna, Alma Mater Studiorum, Dept Med & Surg Sci, I-40138 Bologna, Italy.
C3 University of Bologna; University of Bologna; University of Bologna
RP Cicero, AFG (corresponding author), Univ Bologna, Alma Mater Studiorum, Dept Med & Surg Sci, I-40138 Bologna, Italy.
EM cristiana.caliceti@unibo.it; donato.calabria2@unibo.it;
   aldo.roda@unibo.it; arrigo.cicero@unibo.it
RI caliceti, cristiana/AAW-9614-2020; Cicero, Arrigo/H-8244-2019; Calabria,
   Donato/AAB-1144-2021
OI Roda, Aldo/0000-0001-7649-4797; caliceti, cristiana/0000-0002-6740-5331;
   Cicero, Arrigo Francesco Giuseppe/0000-0002-4367-3884
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   Zhu YY, 2011, ARTHRITIS RHEUM-US, V63, P3136, DOI 10.1002/art.30520
NR 123
TC 180
Z9 201
U1 10
U2 139
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 2072-6643
J9 NUTRIENTS
JI Nutrients
PD APR
PY 2017
VL 9
IS 4
AR 395
DI 10.3390/nu9040395
PG 15
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA EU9JI
UT WOS:000401355600080
PM 28420204
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Caimi, G
   Lo Presti, R
   Montana, M
   Noto, D
   Canino, B
   Averna, MR
   Hopps, E
AF Caimi, Gregorio
   Lo Presti, Rosalia
   Montana, Maria
   Noto, Davide
   Canino, Baldassare
   Averna, Maurizio R.
   Hopps, Eugenia
TI Lipid Peroxidation, Nitric Oxide Metabolites, and Their Ratio in a Group
   of Subjects with Metabolic Syndrome
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Article
ID LOW-DENSITY-LIPOPROTEIN; OXIDATIVE STRESS; INSULIN-RESISTANCE;
   SKELETAL-MUSCLE; POSTMENOPAUSAL WOMEN; MEDITERRANEAN-STYLE; BY-PRODUCTS;
   PLASMA; SYNTHASE; COMPONENTS
AB Our aim was to evaluate lipid peroxidation, expressed as thiobarbituric acid-reactive substances (TBARS), nitric oxide metabolites (nitrite + nitrate) expressed as NOx, and TBARS/NOx. ratio in a group of subjects with metabolic syndrome (MS). In this regard we enrolled 106 subjects with MS defined according to the IDF criteria, subsequently subdivided into diabetic (DMS) and nondiabetic (NDMS) and also into subjects with a low triglycerides/HDL-cholesterol (TG/HDL-C) index or with a high TG/HDL-C index. In the entire group and in the four subgroups of MS subjects we found an increase in TBARS and NOx levels and a decrease in TBARS/NOx ratio in comparison with normal controls. Regarding all these parameters no statistical difference between DMS and NDMS was evident, but a significant increase in NOx was present in subjects with a high TG/HDL-C index in comparison with those with a low index. In MS subjects we also found a negative correlation between TBARS/NOx ratio and TG/HDL-C index. Considering the hyperactivity of the inducible NO synthase in MS, these data confirm the altered redox and inflammatory status that characterizes the MS and suggest a link between lipid peroxidation, inflammation, and insulin resistance, evaluated as TG/HDL-C index.
C1 [Caimi, Gregorio; Lo Presti, Rosalia; Montana, Maria; Noto, Davide; Canino, Baldassare; Averna, Maurizio R.; Hopps, Eugenia] Univ Palermo, Dipartimento Biomed Med Interna & Specialist, I-90100 Palermo, Italy.
C3 University of Palermo
RP Hopps, E (corresponding author), Univ Palermo, Dipartimento Biomed Med Interna & Specialist, Via Vespro 129, I-90100 Palermo, Italy.
EM eugenia.hopps@unipa.it
RI Montaña, Fernanda/ADG-6031-2022; Noto, Davide/AAA-9208-2019; Averna,
   Maurizio/U-9527-2017; LO PRESTI, Rosalia/J-5394-2016
OI Caimi, Gregorio/0000-0001-8964-255X; LO PRESTI,
   Rosalia/0000-0002-7491-568X; Averna, Maurizio/0000-0003-3558-9209; Noto,
   Davide/0000-0002-5346-2829; canino, baldassare/0000-0001-6024-331X
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NR 59
TC 13
Z9 16
U1 0
U2 3
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PY 2014
VL 2014
AR 824756
DI 10.1155/2014/824756
PG 8
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA AJ1QW
UT WOS:000337431800001
PM 24987495
OA Green Submitted, hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Anastasopoulos, NAT
   Lianos, GD
   Tatsi, V
   Karampa, A
   Goussia, A
   Glantzounis, GK
AF Anastasopoulos, Nikolaos-Andreas T.
   Lianos, Georgios D.
   Tatsi, Vera
   Karampa, Anastasia
   Goussia, Anna
   Glantzounis, Georgios K.
TI Clinical heterogeneity in patients with non-alcoholic fatty liver
   disease-associated hepatocellular carcinoma
SO EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY
LA English
DT Review
DE Liver steatosis; NAFLD; hepatocellular carcinoma; metabolic syndrome;
   cirrhosis; survival
ID ELEVATED SERUM FERRITIN; BARIATRIC SURGERY; DIABETES-MELLITUS;
   STEATOHEPATITIS; FIBROSIS; NAFLD; IRON; MANAGEMENT; MORTALITY; CIRRHOSIS
AB Introduction The indisputable increase in nonalcoholic Fatty Liver Disease (NAFLD) prevalence (25% of population) has consequently led to an increase in Hepatocellular Carcinoma (HCC) and liver-related mortality worldwide. The characteristics of patients with HCC, secondary to NAFLD, are older age, large tumors due to late diagnosis, often without cirrhosis and high prevalence of the metabolic syndrome components, leading to an increased mortality rate. Although the mechanisms of disease remain partially obscure, insulin resistance, oxidative stress, apoptosis, iron overload, and excessive local and systemic inflammation are identified as culprits for hepatocarcinogenesis in the presence of NAFLD. Area covered In this review, the authors report that there are no uniform guidelines for surveillance and early diagnosis in this patient group. Barcelona Clinic Liver Cancer staging is generally applicable to HCC due to NAFLD and management depends on liver function, tumor characteristics, and cardiovascular comorbidity. Evidence suggests that HCC due to NAFLD can be associated with worse survival due to late diagnosis. Expert opinion The need for effective early diagnosis and management of NAFLD is urgent, considering the galloping incidence of the obesity and the fact that liver cirrhosis and HCC due to NAFLD will become the first indication for liver transplantation in foreseeable future.
C1 [Anastasopoulos, Nikolaos-Andreas T.] Natl & Kapodistrian Univ Athens, Hippokrate Gen Hosp Athens, Propaedeut Dept Gen Surg 1, Athens, Greece.
   [Anastasopoulos, Nikolaos-Andreas T.; Lianos, Georgios D.; Tatsi, Vera; Karampa, Anastasia; Glantzounis, Georgios K.] Univ Hosp Ioannina, Dept Surg, Ioannina, Greece.
   [Anastasopoulos, Nikolaos-Andreas T.; Lianos, Georgios D.; Tatsi, Vera; Karampa, Anastasia; Goussia, Anna; Glantzounis, Georgios K.] Univ Ioannina, Sch Med, Ioannina, Greece.
   [Goussia, Anna] Univ Hosp Ioannina, Dept Pathol, Ioannina, Greece.
C3 National & Kapodistrian University of Athens; University Hospital
   Ioannina; University of Ioannina; University Hospital Ioannina
RP Glantzounis, GK (corresponding author), Univ Ioannina, Sch Med, Dept Surg, Ioannina 45110, Greece.
EM gglantzounis@uoi.gr
RI Anastasopoulos, Nikolaos-Andreas/JAX-5800-2023
OI Anastasopoulos, Nikolaos-Andreas/0000-0003-1048-0960
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NR 95
TC 15
Z9 15
U1 0
U2 6
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1747-4124
EI 1747-4132
J9 EXPERT REV GASTROENT
JI Expert Rev. Gastroenterol. Hepatol.
PD NOV 1
PY 2020
VL 14
IS 11
BP 1025
EP 1033
DI 10.1080/17474124.2020.1802244
EA AUG 2020
PG 9
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA OD5EX
UT WOS:000565041700001
PM 32746645
DA 2025-06-11
ER

PT J
AU Kar, S
   Shahshahan, HR
   Hackfort, BT
   Yadav, SK
   Yadav, R
   Kambis, TN
   Lefer, DJ
   Mishra, PK
AF Kar, Sumit
   Shahshahan, Hamid R.
   Hackfort, Bryan T.
   Yadav, Santosh K.
   Yadav, Roopali
   Kambis, Tyler N.
   Lefer, David J.
   Mishra, Paras K.
TI Exercise Training Promotes Cardiac Hydrogen Sulfide Biosynthesis and
   Mitigates Pyroptosis to Prevent High-Fat Diet-Induced Diabetic
   Cardiomyopathy
SO ANTIOXIDANTS
LA English
DT Article
DE cardiac remodeling; insulin resistance; inflammasome; metabolic syndrome
ID NLRP3 INFLAMMASOME ACTIVATION; HEART-FAILURE; CYTOKINE PRODUCTION;
   METABOLIC SYNDROME; DIASTOLIC FUNCTION; CELL-DEATH; ER STRESS;
   DYSFUNCTION; OBESITY; RISK
AB Obesity increases the risk of developing diabetes and subsequently, diabetic cardiomyopathy (DMCM). Reduced cardioprotective antioxidant hydrogen sulfide (H2S) and increased inflammatory cell death via pyroptosis contribute to adverse cardiac remodeling and DMCM. Although exercise training (EX) has cardioprotective effects, it is unclear whether EX mitigates obesity-induced DMCM by increasing H2S biosynthesis and mitigating pyroptosis in the heart. C57BL6 mice were fed a high-fat diet (HFD) while undergoing treadmill EX for 20 weeks. HFD mice developed obesity, hyperglycemia, and insulin resistance, which were reduced by EX. Left ventricle pressure-volume measurement revealed that obese mice developed reduced diastolic function with preserved ejection fraction, which was improved by EX. Cardiac dysfunction was accompanied by increased cardiac pyroptosis signaling, structural remodeling, and metabolic remodeling, indicated by accumulation of lipid droplets in the heart. Notably, EX increased cardiac H2S concentration and expression of H2S biosynthesis enzymes. HFD-induced obesity led to features of type 2 diabetes (T2DM), and subsequently DMCM. EX during the HFD regimen prevented the development of DMCM, possibly by promoting H2S-mediated cardioprotection and alleviating pyroptosis. This is the first report of EX modulating H2S and pyroptotic signaling in the heart.
C1 [Kar, Sumit; Shahshahan, Hamid R.; Hackfort, Bryan T.; Yadav, Santosh K.; Yadav, Roopali; Kambis, Tyler N.; Mishra, Paras K.] Univ Nebraska Med Ctr, Dept Cellular & Integrat Physiol, Omaha, NE 68198 USA.
   [Lefer, David J.] Louisiana State Univ, Cardiovasc Ctr Excellence, Dept Pharmacol & Expt Therapeut, Hlth Sci Ctr, New Orleans, LA 70112 USA.
C3 University of Nebraska System; University of Nebraska Medical Center;
   Louisiana State University System; Louisiana State University Health
   Sciences Center New Orleans
RP Mishra, PK (corresponding author), Univ Nebraska Med Ctr, Dept Cellular & Integrat Physiol, Omaha, NE 68198 USA.
EM sumit.kar@unmc.edu; hamid.shahshahan@unmc.edu; bryan.hackfort@unmc.edu;
   santosh.yadav@unmc.edu; yadavroopali@gmail.com; tyler.kambis@unmc.edu;
   dlefe1@lsuhsc.edu; paraskumar.mishra@unmc.edu
RI Yadav, Roopali/HHN-7822-2022; Lefer, David/A-6372-2012; Yadav,
   Santosh/GQZ-7569-2022; Mishra, Paras/ABG-3882-2020
OI Hackfort, Bryan/0000-0002-8472-3622; Lefer, David/0000-0003-2293-7278;
   Yadav, Santosh/0000-0001-9728-4561; Yadav, Roopali/0000-0001-5648-2369;
   Kar, Sumit/0000-0002-8213-8497
FU National Institutes of Health [HL-113281, HL-116205]
FX This work was supported by the National Institutes of Health grants
   HL-113281 and HL-116205 to Paras K. Mishra.
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NR 51
TC 71
Z9 76
U1 0
U2 13
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD DEC
PY 2019
VL 8
IS 12
AR 638
DI 10.3390/antiox8120638
PG 16
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA KB6WN
UT WOS:000506633000071
PM 31835893
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Liang, M
   Li, AQ
   Lou, AJ
   Zhang, XF
   Chen, YY
   Yang, L
   Li, YM
   Yang, SL
   Hou, FF
AF Liang, Min
   Li, Aiqing
   Lou, Aiju
   Zhang, Xifang
   Chen, Youyuan
   Yang, Lei
   Li, Yumin
   Yang, Shenglin
   Hou, Fan Fan
TI Advanced oxidation protein products promote NADPH oxidase-dependent
   β-cell destruction and dysfunction through the Bcl-2/Bax apoptotic
   pathway
SO LABORATORY INVESTIGATION
LA English
DT Article
ID RAT PANCREATIC-ISLETS; ANGIOTENSIN-ALDOSTERONE SYSTEM; METABOLIC
   SYNDROME; DIABETIC-PATIENTS; NAD(P)H OXIDASE; END-PRODUCTS; STRESS;
   GLUCOSE; INFLAMMATION; ACTIVATION
AB The accumulation of plasma advanced oxidation protein products (AOPPs) has been linked with diverse disorders, including diabetes, chronic kidney disease, obesity, and metabolic syndrome. The aim of the present study was to evaluate the pathophysiological relevance of AOPPs in beta-cell destruction and dysfunction. Exposure of cultured rat beta-cells (INS-1) to AOPPs induced an increase in Bax expression, caspase-3 activity, and apoptosis as well as a decrease in Bcl-2 expression in a dose-and time-dependent manner. AOPP challenge rapidly increased the production of intracellular superoxide by activation of NADPH oxidases, demonstrated by p47phox translocation and interaction with p22phox and gp91phox, and this in turn led to apoptosis. AOPPs treatment resulted in beta-cell apoptosis, AOPPs accumulation, and decreased insulin content in pancreas and plasma in unilateral nephrectomized rats. Chronic inhibition of NADPH oxidase by apocynin prevented beta-cell apoptosis and ameliorated insulin deficiency in AOPP-challenged rats. This study demonstrates for the first time that accumulation of AOPPs promotes NADPH oxidase-dependent beta-cell destruction and dysfunction by the Bcl-2/Bax-caspase apoptotic pathway. This finding may provide a mechanistic explanation for beta-cell destruction and dysfunction in patients with diverse disorders.
C1 [Liang, Min; Li, Aiqing; Lou, Aiju; Zhang, Xifang; Chen, Youyuan; Yang, Lei; Li, Yumin; Yang, Shenglin; Hou, Fan Fan] Southern Med Univ, Nanfang Hosp, State Key Lab Organ Failure Res,Div Nephrol, Natl Clin Res Ctr Kidney Dis,Key Clin Specialty D, Guangzhou, Guangdong, Peoples R China.
C3 Southern Medical University - China
RP Hou, FF (corresponding author), Nanfang Hosp, Div Nephrol, 1838 North Guangzhou Ave, Guangzhou 510515, Guangdong, Peoples R China.
EM ffhouguangzhou@163.com
FU National Natural Science Foundation of China [81620108003, 30971382,
   81270825]
FX This study was supported by the National Natural Science Foundation of
   China (Grant Nos. 81620108003 to FFH, 30971382 to ML, and 81270825 to
   AL).
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NR 45
TC 18
Z9 22
U1 1
U2 15
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 0023-6837
EI 1530-0307
J9 LAB INVEST
JI Lab. Invest.
PD JUL
PY 2017
VL 97
IS 7
BP 792
EP 805
DI 10.1038/labinvest.2017.24
PG 14
WC Medicine, Research & Experimental; Pathology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pathology
GA EZ3YR
UT WOS:000404647900004
PM 28263293
OA Bronze
DA 2025-06-11
ER

PT J
AU van Dijk, G
   van Heijningen, S
   Reijne, AC
   Nyakas, C
   van der Zee, EA
   Eisel, ULM
AF van Dijk, Gertjan
   van Heijningen, Steffen
   Reijne, Aaffien C.
   Nyakas, Csaba
   van der Zee, Eddy A.
   Eisel, Ulrich L. M.
TI Integrative neurobiology of metabolic diseases, neuroinflammation, and
   neurodegeneration
SO FRONTIERS IN NEUROSCIENCE
LA English
DT Review
DE neuroinflammation; obesity; metabolic syndrome; type-2 diabetes
   mellitus; TNF; blood-brain barrier; aging; Alzheimer's disease
ID GROWTH-FACTOR-I; HIGH-FAT-DIET; NECROSIS-FACTOR-ALPHA;
   CENTRAL-NERVOUS-SYSTEM; AMYLOID-BETA-PROTEIN; BODY-MASS INDEX;
   TRIGLYCERIDE-RICH LIPOPROTEINS; MILD COGNITIVE IMPAIRMENT; BRAIN-BARRIER
   TRANSPORT; OBESE ZUCKER RATS
AB Alzheimer's disease (AD) is a complex, multifactorial disease with a number of leading mechanisms, including neuroinflammation, processing of amyloid precursor protein (APP) to amyloid peptide, tau protein hyperphosphorylation, relocalization, and deposition. These mechanisms are propagated by obesity, the metabolic syndrome and type-2 diabetes mellitus. Stress, sedentariness, dietary overconsumption of saturated fat and refined sugars, and circadian derangements/disturbed sleep contribute to obesity and related metabolic diseases, but also accelerate age-related damage and senescence that all feed the risk of developing AD too. The complex and interacting mechanisms are not yet completely understood and will require further analysis. Instead of investigating AD as a mono- or oligocausal disease we should address the disease by understanding the multiple underlying mechanisms and how these interact. Future research therefore might concentrate on integrating these by "systems biology" approaches, but also to regard them from an evolutionary medicine point of view. The current review addresses several of these interacting mechanisms in animal models and compares them with clinical data giving an overview about our current knowledge and puts them into an integrated framework.
C1 [van Dijk, Gertjan; van Heijningen, Steffen; Reijne, Aaffien C.] Univ Groningen, Groningen Inst Evolutionary Life Sci, Dept Behav Neurosci, NL-9747 AG Groningen, Netherlands.
   [Reijne, Aaffien C.] Univ Groningen, Univ Med Ctr Groningen, Syst Biol Ctr Energy Metab & Ageing, NL-9747 AG Groningen, Netherlands.
   [Nyakas, Csaba; van der Zee, Eddy A.; Eisel, Ulrich L. M.] Univ Groningen, Groningen Inst Evolutionary Life Sci, Dept Mol Neurobiol, NL-9747 AG Groningen, Netherlands.
   [Eisel, Ulrich L. M.] Univ Groningen, Univ Med Ctr Groningen, Univ Ctr Psychiat, NL-9747 AG Groningen, Netherlands.
C3 University of Groningen; University of Groningen; University of
   Groningen; University of Groningen
RP van Dijk, G (corresponding author), Univ Groningen, Groningen Inst Evolutionary Life Sci, Dept Behav Neurosci, Nijenborgh 7, NL-9747 AG Groningen, Netherlands.
EM gertjan.van.dijk@rug.nl
RI van der Zee, Eddy/AAZ-2120-2020
OI Eisel, Ulrich/0000-0003-4178-0384; van Dijk, Gertjan/0000-0002-6565-4019
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NR 279
TC 57
Z9 61
U1 0
U2 26
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1662-453X
J9 FRONT NEUROSCI-SWITZ
JI Front. Neurosci.
PD MAY 18
PY 2015
VL 9
AR 173
DI 10.3389/fnins.2015.00173
PG 19
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA CS3NO
UT WOS:000361981400001
PM 26041981
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Giorgio, V
   Prono, F
   Graziano, F
   Nobili, V
AF Giorgio, Valentina
   Prono, Federica
   Graziano, Francesca
   Nobili, Valerio
TI Pediatric non alcoholic fatty liver disease: old and new concepts on
   development, progression, metabolic insight and potential treatment
   targets
SO BMC PEDIATRICS
LA English
DT Review
DE Nonalcoholic fatty liver disease; Non-alcoholic steatohepatatis;
   Obesity; Metabolic syndrome
ID CARDIOVASCULAR RISK-FACTORS; NECROSIS-FACTOR-ALPHA; ELEVATED ALANINE
   AMINOTRANSFERASE; NAFLD FIBROSIS INDEX; OBESE CHILDREN; NONALCOHOLIC
   STEATOHEPATITIS; INSULIN-RESISTANCE; HEPATIC STEATOSIS; LIFE-STYLE;
   OXIDATIVE STRESS
AB Nonalcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease in children. NAFLD has emerged to be extremely prevalent, and predicted by obesity and male gender. It is defined by hepatic fat infiltration >5% hepatocytes, in the absence of other causes of liver pathology. It includes a spectrum of disease ranging from intrahepatic fat accumulation (steatosis) to various degrees of necrotic inflammation and fibrosis (non-alcoholic steatohepatatis [NASH]). NAFLD is associated, in children as in adults, with severe metabolic impairments, determining an increased risk of developing the metabolic syndrome. It can evolve to cirrhosis and hepatocellular carcinoma, with the consequent need for liver transplantation. Both genetic and environmental factors seem to be involved in the development and progression of the disease, but its physiopathology is not yet entirely clear. In view of this mounting epidemic phenomenon involving the youth, the study of NAFLD should be a priority for all health care systems. This review provides an overview of current and new clinical-histological concepts of pediatric NAFLD, going through possible implications into patho-physiolocical and therapeutic perspectives.
C1 [Giorgio, Valentina; Prono, Federica; Graziano, Francesca; Nobili, Valerio] Bambino Gesu Children Hosp, Hepatometab Unit, Rome, Italy.
C3 IRCCS Bambino Gesu
RP Giorgio, V (corresponding author), Bambino Gesu Children Hosp, Hepatometab Unit, Rome, Italy.
EM valentagio@yahoo.it
RI Nobili, Valerio/K-8670-2018; Giorgio, Valentina/I-6110-2016
OI nobili, valerio/0000-0002-4570-3979; Giorgio,
   Valentina/0000-0002-7448-8710
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NR 95
TC 124
Z9 142
U1 0
U2 20
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-2431
J9 BMC PEDIATR
JI BMC Pediatr.
PD MAR 25
PY 2013
VL 13
AR 40
DI 10.1186/1471-2431-13-40
PG 10
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA 119YQ
UT WOS:000317136400001
PM 23530957
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Alessi, MC
   Poggi, M
   Juhan-Vague, I
AF Alessi, Marie-Christine
   Poggi, Marjorie
   Juhan-Vague, Irene
TI Rasminogen activator inhibitor-1, adipose tissue and insulin resistance
SO CURRENT OPINION IN LIPIDOLOGY
LA English
DT Review
DE adipose tissue; atherothrombosis; metabolic syndrome; obesity;
   plasminogen activator inhibitor-1
ID NECROSIS-FACTOR-ALPHA; NUTRITIONALLY INDUCED OBESITY; CIRCADIAN CLOCK;
   METABOLIC SYNDROME; ENDOTHELIAL DYSFUNCTION; MURINE MODEL; I GENE;
   PAI-1; EXPRESSION; POLYMORPHISM
AB Purpose of review Plasminogen activator inhibitor (PAI)-1 is a physiological inhibitor of plasminogen activators (urokinase and tissue types) and vitronectin. It is synthesized by adipose tissue, and its levels in plasma are increased in obesity and reduced with weight loss. Circulating PAI-1 level predicts development of type 2 diabetes, suggesting that it may be causally related to development of obesity. A role for PAI-1 in development of obesity has only partially been established, however. This review summarizes current knowledge, gives context to developments thus far and discusses controversies.
   Recent findings, In addition to its role in atherothrombosis, PAI-1 might be involved in adipose tissue development. PAI-1 is produced by ectopic fat depots under the influence of inducers. Among the most recently described inducers are inflammation, oxidative stress and circadian clock protein. PAI-1 may play several roles in contributing to obesity: through indirect effects on insulin signalling, by influencing adipocyte differentiation and by regulating recruitment of inflammatory cells within adipose tissue.
   Summary These recent findings emphasize the involvement of PAH in controlling the biology of adipose tissue; PAI-1 is an attractive new therapeutic target to retard the metabolic complications that accompany obesity.
C1 Fac Med Marseille, INSERM, UMR 626, Hematol Lab, F-13385 Marseille 5, France.
C3 Aix-Marseille Universite; Institut National de la Sante et de la
   Recherche Medicale (Inserm)
RP Alessi, MC (corresponding author), Fac Med Marseille, INSERM, UMR 626, Hematol Lab, 27 Bd Jean Moulin, F-13385 Marseille 5, France.
EM marie-christine.alessi@medecine.univ-mrs.fr
RI poggi, marjorie/ABG-6438-2021; ALESSI, Marie-christine/AAK-3582-2020
OI poggi, marjorie/0000-0001-6331-9682; ALESSI,
   Marie-christine/0000-0003-3927-5792
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NR 68
TC 164
Z9 181
U1 0
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0957-9672
EI 1473-6535
J9 CURR OPIN LIPIDOL
JI Curr. Opin. Lipidology
PD JUN
PY 2007
VL 18
IS 3
BP 240
EP 245
DI 10.1097/MOL.0b013e32814e6d29
PG 6
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism; Peripheral
   Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism;
   Cardiovascular System & Cardiology
GA 176LJ
UT WOS:000247086300002
PM 17495595
DA 2025-06-11
ER

PT J
AU Stump, CS
   Henriksen, EJ
   Wei, YZ
   Sowers, JR
AF Stump, Craig S.
   Henriksen, Erik J.
   Wei, Yongzhong
   Sowers, James R.
TI The metabolic syndrome: Role of skeletal muscle metabolism
SO ANNALS OF MEDICINE
LA English
DT Review
DE adiponectin; antioxidants; inflammatory cytokines; insulin resistance;
   intramyocellular lipid; metabolic flexibility; physical activity;
   reactive oxygen species; renin-angiotensin-aldosterone system (RAAS)
ID ALPHA-LIPOIC ACID; NECROSIS-FACTOR-ALPHA; ANGIOTENSIN-CONVERTING ENZYME;
   INDUCED INSULIN-RESISTANCE; TYPE-2 DIABETES-MELLITUS; ACTIVATED
   SIGNALING PATHWAYS; RECEPTOR SUBSTRATE PROTEINS; OXIDATIVE STRESS;
   GLUCOSE-TRANSPORT; SERINE PHOSPHORYLATION
AB Skeletal muscle constitutes the largest insulin-sensitive tissue in the body and is the primary site for insulin-stimulated glucose utilization. Skeletal muscle resistance to insulin is fundamental to the metabolic dysregulation associated with obesity and physical inactivity, and contributes to the development of the metabolic syndrome (MS). The inability to efficiently take up and store fuel, and to transition from fat to glucose as the primary source of fuel during times of caloric abundance (high insulin) or scarcity (low insulin) has been termed metabolic inflexibility which contributes to a whole body metabolic dysregulation and cardiovascular risk. Potential mechanisms contributing to reduced insulin signaling and action in skeletal muscle includes adipose tissue expansion and increased inflammatory adipokines, increased renin-angiotensin-aldosterone system (RAAS) activity, decreases in muscle mitochondrial oxidative capacity, increased intramuscular lipid accumulation, and increased reactive oxygen species. Future research is focused upon understanding these and other potential mechanisms in order to identify therapeutic targets for reducing MS risk. Strategies will include adequate physical activity and maintaining a healthy weight, but may also require specific pharmacologic interventions.
C1 Harry S Truman VA Med Ctr, MU Diabet & Cardiovasc Res Ctr, Columbia, MO USA.
   Harry S Truman VA Med Ctr, Dept Internal Med Endocrinol, Columbia, MO USA.
   Univ Arizona, Dept Physiol, Tucson, AZ USA.
C3 US Department of Veterans Affairs; Veterans Health Administration (VHA);
   Harry S. Truman Memorial Veterans' Hospital; University of Missouri
   System; University of Missouri Columbia; US Department of Veterans
   Affairs; Veterans Health Administration (VHA); Harry S. Truman Memorial
   Veterans' Hospital; University of Arizona
RP Stump, CS (corresponding author), Univ Missouri, Dept Internal Med Endocrinol, 1 Hosp Dr,D110A, Columbia, MO 65212 USA.
EM stumpc@health.missouri.edu
FU NHLBI NIH HHS [1R01-HL073101-02] Funding Source: Medline
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NR 150
TC 266
Z9 309
U1 0
U2 22
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0785-3890
EI 1365-2060
J9 ANN MED
JI Ann. Med.
PY 2006
VL 38
IS 6
BP 389
EP 402
DI 10.1080/07853890600888413
PG 14
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 096VM
UT WOS:000241404900002
PM 17008303
DA 2025-06-11
ER

PT J
AU Wang, JH
   Hwang, SJ
   Shin, KS
   Lim, DW
   Son, CG
AF Wang, Jing-Hua
   Hwang, Seung-Ju
   Shin, Kwang-Soo
   Lim, Dong-Woo
   Son, Chang-Gue
TI Bacillus subtilis-Fermented Amomum xanthioides Ameliorates
   Metabolic-Syndrome-Like Pathological Conditions in Long-Term HFHFD-Fed
   Mice
SO ANTIOXIDANTS
LA English
DT Article
DE Bacillus subtilis; Amomum xanthioides; fermentation; metabolic diseases;
   oxidative stress; gut microbiota
AB In modern society, numerous metabolic disorders are widespread globally. The present study aimed to demonstrate whether Bacillus subtilis-fermented Amomum xanthioides (BSAX) exerts anti-metabolic disturbance effects compared with the ethyl acetate fraction of Amomum xanthioides (EFAX), a previously verified functional fraction. Mice fed with a high-fat, high-fructose diet (HFHFD) for 10 wk presented a typical model of metabolic dysfunction, and BSAX significantly attenuated a string of metabolic-syndrome-related pathological parameters, such as body, fat, organ mass, lipid markers (TGs, TC, free fatty acids), and glucose metabolism (glucose, insulin), without influencing appetite. Further, BSAX markedly lowered malondialdehyde (MDA) and ROS in the blood and restored antioxidative parameters (SOD, GSH, and CAT in liver tissue, and total bilirubin in serum) by elevating Nrf2 and HO-1. Moreover, BSAX noticeably restored gut microbiota diversity and normalized lipid-metabolism-associated proteins, including SREBP-1, p-AMPK, and PPAR-alpha. Generally, most metabolic parameters were improved by BSAX to a greater extent than EFAX, except for liver weight and hepatic TC. In conclusion, BSAX alleviates metabolic dysfunction by enhancing lipid metabolism and antioxidative capacity and is more effective than EFAX. Therefore, the application of high-yield, effective BSAX might be a promising approach for curing and preventing metabolic disorders.
C1 [Wang, Jing-Hua; Hwang, Seung-Ju; Son, Chang-Gue] Daejeon Univ, Inst Biosci & Integrat Med, 75 Daedeok daero 176, Daejeon 35235, South Korea.
   [Wang, Jing-Hua; Hwang, Seung-Ju; Son, Chang-Gue] Daejeon Korean Med Hosp, Liver & Immunol Res Ctr, 75 Daedeok daero 176, Daejeon 35235, South Korea.
   [Shin, Kwang-Soo] Daejeon Univ, Grad Sch, Dept Microbiol, Daejeon 34520, South Korea.
   [Lim, Dong-Woo] Dongguk Univ, Coll Korean Med, Dept Diagnost, Dongguk Ro 32, Goyang 10326, South Korea.
C3 Daejeon University; Daejeon University; Dongguk University
RP Wang, JH; Son, CG (corresponding author), Daejeon Univ, Inst Biosci & Integrat Med, 75 Daedeok daero 176, Daejeon 35235, South Korea.; Wang, JH; Son, CG (corresponding author), Daejeon Korean Med Hosp, Liver & Immunol Res Ctr, 75 Daedeok daero 176, Daejeon 35235, South Korea.
EM wjhdon@dju.kr; ckson@dju.kr
RI Lim, Dongwoo/GLU-0640-2022; son, chang gue/ABC-2215-2021; Wang,
   Jing-hua/AAO-2350-2020; Hwang, Seung-Ju/MTF-4411-2025
OI Lim, Dongwoo/0000-0002-3179-9439; Wang, jing-hua/0000-0002-2034-7429;
   Son, Chang-Gue/0000-0003-4876-0167; Hwang, Seung-Ju/0000-0003-1037-9133
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NR 53
TC 6
Z9 6
U1 0
U2 4
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD NOV
PY 2022
VL 11
IS 11
AR 2254
DI 10.3390/antiox11112254
PG 15
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA 6U4QW
UT WOS:000894354200001
PM 36421440
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Jang, HH
   Lee, J
   Lee, SH
   Lee, YM
AF Jang, Hwan-Hee
   Lee, Jounghee
   Lee, Sung-Hyen
   Lee, Young-Min
TI Effects of Capsicum annuum supplementation on the components of
   metabolic syndrome: a systematic review and meta-analysis
SO SCIENTIFIC REPORTS
LA English
DT Review
ID NON-PUNGENT CULTIVAR; ALL-CAUSE MORTALITY; RED-PEPPER; OXIDATIVE STRESS;
   CH-19 SWEET; ANTHROPOMETRIC INDEXES; CARDIOVASCULAR-DISEASE; ANTIOXIDANT
   ACTIVITY; DIABETES-MELLITUS; BODY-TEMPERATURE
AB Metabolic syndrome (MetS) has increasingly gained importance as the main risk factor for cardiovascular diseases and type II diabetes mellitus. Various natural compounds derived from plants are associated with beneficial effects on the incidence and progression of MetS. This study aimed to evaluate the effects of Capsicum annuum on factors related to MetS by assessing randomized controlled trials (written in English). We searched the online databases of PubMed, Embase, Google scholar, and Cochrane Library up to April 2020. 'Patient/Population, Intervention, Comparison and Outcomes' format was used to determine whether intervention with C. annuum supplementation compared with placebo supplementation had any effect on the components of MetS among participants. We considered standardized mean differences (SMD) with 95% confidence intervals (CI) as effect size measures using random-effects model. Analysis of the included 11 studies (n=609) showed that C. annuum supplementation had significant effect on low density lipoprotein-cholesterol [SMD=- 0.39; 95% CI - 0.72, - 0.07; P=0.02; prediction interval, - 1.28 to 0.50] and marginally significant effect on body weight [SMD=- 0.19; 95% CI - 0.40, 0.03; P=0.09]. However, larger and well-designed clinical trials are needed to investigate the effects of C. annuum on MetS.
C1 [Jang, Hwan-Hee; Lee, Sung-Hyen] Rural Dev Adm, Funct Food Div, Natl Inst Agr Sci, Wonju 55365, South Korea.
   [Lee, Jounghee] Kunsan Natl Univ, Dept Food & Nutr, Gunsan 54150, South Korea.
   [Lee, Young-Min] Seoul Womens Univ, Div Appl Food Syst, Major Food & Nutr, Seoul 01797, South Korea.
C3 Rural Development Administration (RDA), Republic of Korea; National
   Institute of Agricultural Sciences; Kunsan National University; Seoul
   Women's University
RP Lee, YM (corresponding author), Seoul Womens Univ, Div Appl Food Syst, Major Food & Nutr, Seoul 01797, South Korea.
EM ymlee@swu.ac.kr
RI Jang, HwanHee/KWT-7773-2024
FU National Institute of Agricultural Science (NAS)-Rural Development
   Administration (RDA), South Korea [PJ01420101]; Seoul Women's
   University, South Korea [2020-0389]
FX This research was supported by a research program for Agricultural
   Science & Technology Development from National Institute of Agricultural
   Science (NAS)-Rural Development Administration (RDA), South Korea (Grant
   number: PJ01420101), and by a research grant from Seoul Women's
   University, South Korea (Grant number 2020-0389).
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NR 61
TC 22
Z9 22
U1 0
U2 9
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD DEC 1
PY 2020
VL 10
IS 1
AR 20912
DI 10.1038/s41598-020-77983-2
PG 11
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA PU0CK
UT WOS:000608975400024
PM 33262398
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Chielle, EO
   Bonfanti, G
   De Bona, KS
   Moresco, RN
   Moretto, MB
AF Chielle, Eduardo Ottobelli
   Bonfanti, Gabriela
   De Bona, Karine Santos
   Moresco, Rafael Noal
   Moretto, Maria Beatriz
TI Adenosine deaminase, dipeptidyl peptidase-IV activities and lipid
   peroxidation are increased in the saliva of obese young adult
SO CLINICAL CHEMISTRY AND LABORATORY MEDICINE
LA English
DT Article
DE adenosine deaminase; dipeptidyl peptidase-IV; lipid peroxidation;
   obesity; saliva
ID BODY-MASS INDEX; METABOLIC SYNDROME; ADIPOSE-TISSUE; OXIDATIVE STRESS;
   LIPOLYSIS; ASSOCIATION; INHIBITION; ENZYME; CD26
AB Background: Obesity is the hallmark of the metabolic syndrome representing a major global health problem. It is considered a state of chronic inflammation with minimal exploration of salivary biomarkers. Thus, the intent of the present study was to assess the activities of salivary dipeptidyl peptidase IV (DPP-IV), adenosine deaminase (ADA) and lipid peroxidation in obese young and overweight young subjects.
   Methods: ADA, DPP-IV activities and lipid peroxidation were investigated in saliva, as well as insulin, glucose, HbA(1c), HOMA and anthropometric measurements in 149 young adults, including 54 with normal weight, 27 overweight and 68 obese subjects.
   Results: Salivary ADA and DPP-IV activities as well as lipid peroxidation were higher in patients with obesity compared to the normal weight group. Correlations between ADA/DPP-IV activities, lipid peroxidation/ADA activity, ADA activity/hip circumference and BMI/weight were observed.
   Conclusions: Our results indicate that the increase in the salivary ADA and DPP-IV activities as well as in the lipid peroxidation could be related of the regulation to various aspects of adipose tissue function and inflammatory obesity. It is suggested that these salivary biomarkers may be used as biochemical test in clinical abnormalities present in obesity, in the absence of oral inflammatory diseases.
C1 [Chielle, Eduardo Ottobelli; Moresco, Rafael Noal; Moretto, Maria Beatriz] Fed Univ Santa Maria UFSM, Ctr Hlth Sci, Dept Clin & Toxicol Anal, Postgrad Program Pharmaceut Sci, BR-97105900 Santa Maria, RS, Brazil.
   [Chielle, Eduardo Ottobelli] Univ West Santa Catarina, UNOESC, Ctr Hlth Sci, Sao Miguel Do Oeste, SC, Brazil.
   [Bonfanti, Gabriela; De Bona, Karine Santos; Moresco, Rafael Noal] UFSM Santa Maria, Ctr Hlth Sci, Postgrad Program Pharmacol, Santa Maria, RS, Brazil.
C3 Universidade Federal de Santa Maria (UFSM); Universidade do Oeste de
   Santa Catarina; Universidade Federal de Santa Maria (UFSM)
RP Moretto, MB (corresponding author), Fed Univ Santa Maria UFSM, Ctr Hlth Sci, Dept Clin & Toxicol Anal, Postgrad Program Pharmaceut Sci, BR-97105900 Santa Maria, RS, Brazil.
EM Beatriz@smail.ufsm.br
RI Moresco, Rafael/K-6118-2017
OI Moresco, Rafael/0000-0003-3072-5080; Bonfanti-Azzolin,
   Gabriela/0000-0003-2602-6092
FU Brazilian National Research Council (CNPq) [477029/2011-6]
FX The work had the financial support of the Brazilian National Research
   Council (CNPq), Universal no 477029/2011-6.
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NR 37
TC 11
Z9 13
U1 0
U2 6
PU WALTER DE GRUYTER GMBH
PI BERLIN
PA GENTHINER STRASSE 13, D-10785 BERLIN, GERMANY
SN 1434-6621
EI 1437-4331
J9 CLIN CHEM LAB MED
JI Clin. Chem. Lab. Med.
PD JUN
PY 2015
VL 53
IS 7
BP 1041
EP 1047
DI 10.1515/cclm-2014-1086
PG 7
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA CJ3XR
UT WOS:000355418300019
PM 25527815
DA 2025-06-11
ER

PT J
AU de Quixano, BB
   Villena, JA
   Aranda, M
   Brils, G
   Cuevas, A
   Hespel, T
   Lekuona, H
   Súarez, C
   Tornavaca, O
   Meseguer, A
AF Bardaji de Quixano, Beatriz
   Villena, Josep A.
   Aranda, Miguel
   Brils, Gemma
   Cuevas, Antoni
   Hespel, Theana
   Lekuona, Haizea
   Suarez, Cristina
   Tornavaca, Olga
   Meseguer, Anna
TI Kidney Androgen-Regulated Protein (KAP) Transgenic Mice Are Protected
   Against High-Fat Diet Induced Metabolic Syndrome
SO SCIENTIFIC REPORTS
LA English
DT Article
ID RENIN-ANGIOTENSIN SYSTEM; CARDIOVASCULAR-DISEASE; INSULIN-RESISTANCE;
   OXIDATIVE STRESS; ADIPOSE-TISSUE; TNF-ALPHA; OBESITY; EXPRESSION;
   HYPERTENSION; INFLAMMATION
AB Metabolic Syndrome (MS) is reaching epidemic proportions with significant social and economical burden worldwide. Since the molecular basis of MS remains poorly defined, we investigated the impact of KAP, a kidney specific androgen-regulated gene, in the development of high fat-diet (hfd)-induced MS. Tg mice overexpressing KAP specifically in proximal tubule cells of the kidney exhibited reduced body weight and lower liver and adipose tissue weight compared to control littermates when fed a hfd. KAP Tg mice showed diminished adipocyte hypertrophy and reduced hepatic steatosis, significantly correlating with expression of relevant molecular markers and lower lipid content in liver. KAP transgenic were protected from hfd-induced insulin resistance, increased blood pressure and exhibited lower IL-6 serum levels and diminished expression of inflammatory markers in the adipose. Moreover, KAP was localized in the secretory pathway of proximal tubule cells and it is released to the extracellular media, preventing IL-6 induction and STAT-3 activation upon TNF alpha stimulation. We conclude that KAP, which might act as a hormone-like product in extra-renal tissues, protects Tg mice against hfd-induced MS by preventing inflammatory related events that are mediated, in part, through the IL-6 pathway.
C1 [Bardaji de Quixano, Beatriz; Aranda, Miguel; Brils, Gemma; Cuevas, Antoni; Hespel, Theana; Lekuona, Haizea; Suarez, Cristina; Tornavaca, Olga; Meseguer, Anna] VHIR, Ctr Invest Bioquim & Biol Mol CIBBIM, Fisiopatol Renal, Barcelona, Spain.
   [Villena, Josep A.] VHIR, Lab Metab & Obes, Barcelona, Spain.
   [Meseguer, Anna] Univ Autonoma Barcelona, Dept Bioquim & Biol Mol, Unitat Bioquim Med, Bellaterra, Barcelona, Spain.
   [Meseguer, Anna] Fdn Renal Inigo Alvarez de Toledo, Inst Reina Sofia Invest Nefrol, Alvarez De Toledo, Spain.
   [Meseguer, Anna] Inst Carlos III FEDER, Red Invest Renal REDINREN, Madrid, Spain.
C3 Autonomous University of Barcelona; Hospital Universitari Vall d'Hebron;
   Vall d'Hebron Institut de Recerca (VHIR); Autonomous University of
   Barcelona; Hospital Universitari Vall d'Hebron; Vall d'Hebron Institut
   de Recerca (VHIR); Autonomous University of Barcelona
RP Meseguer, A (corresponding author), VHIR, Ctr Invest Bioquim & Biol Mol CIBBIM, Fisiopatol Renal, Barcelona, Spain.; Meseguer, A (corresponding author), Univ Autonoma Barcelona, Dept Bioquim & Biol Mol, Unitat Bioquim Med, Bellaterra, Barcelona, Spain.; Meseguer, A (corresponding author), Fdn Renal Inigo Alvarez de Toledo, Inst Reina Sofia Invest Nefrol, Alvarez De Toledo, Spain.; Meseguer, A (corresponding author), Inst Carlos III FEDER, Red Invest Renal REDINREN, Madrid, Spain.
EM ana.meseguer@vhir.org
RI Aranda, Miguel/M-1236-2014; Villena, Josep/H-1597-2015; Navarro,
   Anna/M-2222-2014
OI Bardaji de Quixano, Beatriz/0000-0001-7456-355X; Aranda Martin,
   Miguel/0000-0002-4033-641X; Villena, Josep A/0000-0002-2200-2985
FU Ministerio de Economia y Competitividad [SAF2011-2950, SAF2014-59945-R,
   SAF2012-39484]; Fundacion Senefro (SEN); Instituto de Salud Carlos III
   [PIE13/00027]; Red de InvestigacionRenal REDinREN [12/0021/0013]
FX This work was supported in part by grants from Ministerio de Economia y
   Competitividad (SAF2011-2950 and SAF2014-59945-R to A. Meseguer), the
   Fundacion Senefro (SEN to A. Meseguer), Ministerio de Economia y
   Competitividad (SAF2012-39484 to J.A. Villena), Instituto de Salud
   Carlos III (PIE13/00027), and Red de InvestigacionRenal REDinREN
   (12/0021/0013 to A. Meseguer). Meseguer's research group holds the
   Quality Mention from the Generalitat de Catalunya (2014 SGR). We deeply
   thank Dr. Manoocher Soleimani (University of Cincinnati Ohio, USA) and
   Dra. Angela Nieto (Instituto de Neurociencias, CSIC-UMH, Alicante,
   Spain) for critical reading of the manuscript, and Dra. Esther Sole and
   Veronica Olmedo for technical help and advice.
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NR 42
TC 6
Z9 6
U1 0
U2 2
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD NOV 23
PY 2017
VL 7
AR 16102
DI 10.1038/s41598-017-16487-y
PG 13
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA FN6MP
UT WOS:000416129200014
PM 29170528
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Machado, ADC
   Barbosa, TC
   Sales, ARK
   de Souza, MN
   da Nobrega, ACL
   Silva, BM
AF Machado, Alessandro da Costa
   Barbosa, Thales Coelho
   Kluser Sales, Allan Robson
   de Souza, Marcio Nogueira
   Lucas da Nobrega, Antonio Claudio
   Silva, Bruno Moreira
TI Adults with Initial Metabolic Syndrome have Altered Muscle Deoxygenation
   During Incremental Exercise
SO OBESITY
LA English
DT Article
ID NEAR-INFRARED SPECTROSCOPY; LOWER AEROBIC CAPACITY; BLOOD-FLOW;
   SKELETAL-MUSCLE; CARDIORESPIRATORY FITNESS; SUBMAXIMAL EXERCISE; O-2
   EXTRACTION; MENTAL STRESS; HUMANS; YOUNG
AB Objective: Reduced aerobic power is independently associated with metabolic syndrome ( MetS) incidence and prevalence in adults. This study investigated whether muscle deoxygenation ( proxy of microvascular O-2 extraction) during incremental exercise is altered in MetS and associated with reduced oxygen consumption ( (V) over dotO(2peak)).
   Methods: Twelve men with initial MetS ( no overt diseases and medication-naive; mean+/-SD, age 38+/-7 years) and 12 healthy controls ( HCs) ( 34+/-7 years) completed an incremental cycling test to exhaustion, in which pulmonary ventilation and gas exchange ( metabolic analyzer), as well as vastus lateralis deoxygenation ( near infrared spectroscopy), were measured.
   Results: Subjects with MetS, in contrast to HCs, showed lower (V) over dotO(2peak) normalized to total lean mass, similar (V) over dotO(2peak) response to exercise, and earlier break point ( BP) in muscle deoxygenation. Consequently, deoxygenation slope from BP to peak exercise was greater. Furthermore, absolute (V) over dotO(2peak) was positively associated with BP in correlations adjusted for total lean mass.
   Conclusions: MetS, without overt diseases, altered kinetics of muscle deoxygenation during incremental exercise, particularly at high-intensity exercise. Therefore, the balance between utilization and delivery of O-2 within skeletal muscle is impaired early in MetS natural history, which may contribute to the reduction in aerobic power.
C1 [Machado, Alessandro da Costa; Barbosa, Thales Coelho; Kluser Sales, Allan Robson; Lucas da Nobrega, Antonio Claudio] Univ Fed Fluminense, Dept Physiol & Pharmacol, Niteroi, RJ, Brazil.
   [de Souza, Marcio Nogueira] Univ Fed Rio de Janeiro, Dept Elect & Comp, Rio De Janeiro, Brazil.
   [Silva, Bruno Moreira] Univ Fed Sao Paulo, Dept Physiol, Sao Paulo, Brazil.
C3 Universidade Federal Fluminense; Universidade Federal do Rio de Janeiro;
   Universidade Federal de Sao Paulo (UNIFESP)
RP Silva, BM (corresponding author), Univ Fed Sao Paulo, Dept Physiol, Sao Paulo, Brazil.
EM silva.bruno@unifesp.br
RI Sales, Allan/ABA-8691-2021; da Nobrega, Antonio/O-5107-2019; Souza,
   Marcio/G-8547-2017; Barbosa, Thales/B-4617-2015; Silva,
   Bruno/F-7781-2010
OI Souza, Marcio/0000-0001-9409-3786; Barbosa, Thales/0000-0001-5776-3824;
   Silva, Bruno/0000-0003-0473-3706
FU National Council for Scientific and Technological Development (CNPq)
   [PRONEX - 17/2009]; Foundation of Research Support of Rio de Janeiro
   State (FAPERJ) [E-26/102.378/2009]
FX The study was supported by grants from the National Council for
   Scientific and Technological Development (CNPq; PRONEX - 17/2009) and
   the Foundation of Research Support of Rio de Janeiro State (FAPERJ;
   grant: E-26/102.378/2009).
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NR 40
TC 5
Z9 5
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1930-7381
EI 1930-739X
J9 OBESITY
JI Obesity
PD FEB
PY 2017
VL 25
IS 2
BP 424
EP 431
DI 10.1002/oby.21744
PG 8
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA EL9WF
UT WOS:000394970100027
PM 28059464
DA 2025-06-11
ER

PT J
AU Macfarlane, DP
   Forbes, S
   Walker, BR
AF Macfarlane, David P.
   Forbes, Shareen
   Walker, Brian R.
TI Glucocorticoids and fatty acid metabolism in humans: fuelling fat
   redistribution in the metabolic syndrome
SO JOURNAL OF ENDOCRINOLOGY
LA English
DT Review
ID 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1; HUMAN ADIPOSE-TISSUE;
   INDUCED INSULIN-RESISTANCE; LOW-DENSITY LIPOPROTEIN; DE-NOVO
   LIPOGENESIS; GLYCEROL PHOSPHATE ACYLTRANSFERASE; CARDIOVASCULAR
   RISK-FACTORS; GROWTH-HORMONE DEFICIENCY; CULTURED RAT HEPATOCYTES;
   MESSENGER-RNA LEVELS
AB Glucocorticoid hormones constitute an integral component of the response to stress, and many of the manifestations of glucocorticoid excess (Cushing's syndrome) are predictable on the basis of their acute effects to raise blood pressure, induce insulin resistance, increase protein catabolism and elevate plasma glucose. However, it appears to be a paradox that the acute lipolytic effect of glucocorticoids is not manifest in long-term weight loss in humans. The effects of glucocorticoids on glucose inetabolism are well characterised, involving impaired peripheral glucose uptake and hepatic insulin resistance, and there is mounting evidence that subtle abnormalities in glucocorticoid concentrations in the plasma and/or in tissue sensitivity to glucocorticoids are important in metabolic syndroine. The I effects of glucocorticoids on fatty acid metabolism are less well understood than their influence on glucose metabolism. In this article, we review the literature describing the effects of glucocorticoids on fatty acid metabolism, with particular reference to ill Vi[A) human studies. We consider the implications for contrasting acute Versus chronic effects of glucocorticoids on fat accumulation, effects in different adipose depots and the potential role of glucocorticoid signalling in the pathogenesis and therapy of metabolic syndrome.
C1 [Macfarlane, David P.; Forbes, Shareen; Walker, Brian R.] Univ Edinburgh, Ctr Cardiovasc Sci, Queens Med Res Inst, Endocrinol Unit, Edinburgh EH16 4TJ, Midlothian, Scotland.
C3 University of Edinburgh
RP Walker, BR (corresponding author), Univ Edinburgh, Ctr Cardiovasc Sci, Queens Med Res Inst, Endocrinol Unit, 47 Little France Crescent, Edinburgh EH16 4TJ, Midlothian, Scotland.
EM b.walker@ed.ac.uk
RI Forbes, Shareen/AAG-1816-2021
OI Forbes, Shareen/0000-0002-9127-0641
FU British Heart Foundation Funding Source: Medline; Wellcome Trust Funding
   Source: Medline
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NR 169
TC 292
Z9 342
U1 1
U2 40
PU BIOSCIENTIFICA LTD
PI BRISTOL
PA EURO HOUSE, 22 APEX COURT WOODLANDS, BRADLEY STOKE, BRISTOL BS32 4JT,
   ENGLAND
SN 0022-0795
EI 1479-6805
J9 J ENDOCRINOL
JI J. Endocrinol.
PD MAY
PY 2008
VL 197
IS 2
BP 189
EP 204
DI 10.1677/JOE-08-0054
PG 16
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 302PL
UT WOS:000255980600001
PM 18434349
OA Bronze
DA 2025-06-11
ER

PT J
AU Duncan, BB
   Schmidt, MI
AF Duncan, Bruce B.
   Schmidt, Maria Ines
TI The epidemiology of low-grade chronic systemic inflammation and type 2
   diabetes
SO DIABETES TECHNOLOGY & THERAPEUTICS
LA English
DT Article
ID C-REACTIVE PROTEIN; BLOOD-CELL COUNT; METABOLIC SYNDROME;
   ATHEROSCLEROSIS RISK; INSULIN-RESISTANCE; CARDIOVASCULAR-DISEASE;
   SUBCLINICAL INFLAMMATION; INDEPENDENT PREDICTOR; PLASMA ADIPONECTIN;
   OXIDATIVE STRESS
AB The fattening of the human species and the accompanying emergence of the metabolic syndrome and of type 2 diabetes as remarkably frequent clinical entities are among the major epidemiologic events of our time. Control of the diabetes epidemic requires a greater understanding of the pathophysiologic processes underlying these phenomena. Many epidemiologic studies have now shown associations between inflammation markers and diabetes, with the most consistent being for leukocytes and the strongest being for C-reactive protein. Consistent protective associations have also been reported for adiponectin, an adipocyte secretory protein with anti-inflammatory actions. Although great variability is seen between reported associations, as a whole these studies suggest a role for inflammation linked to obesity. The variability reported is in part due to differences in model adjustment, in how diabetes was ascertained, and in the different means used to operationalize the concept of low-grade chronic systemic inflammation. It is also due, in part, to sample characterization, as findings are heterogeneous across some subgroups, such as those defined by smoking. Consistent with their association with type 2 diabetes, inflammation markers have also be shown to predict conditions present in the prediabetes state such as weight gain, hypertension, gestational diabetes, and decline in insulin sensitivity.
C1 Univ Fed Rio Grande do Sul, Fac Med, Sch Med, Grad Studies Program Epidemiol, BR-90035003 Porto Alegre, RS, Brazil.
C3 Universidade Federal do Rio Grande do Sul
RP Duncan, BB (corresponding author), Univ Fed Rio Grande do Sul, Fac Med, Sch Med, Grad Studies Program Epidemiol, Predio Ciclo Basico,R Ramiro Barcelos 2600-414, BR-90035003 Porto Alegre, RS, Brazil.
EM bbduncan@orion.ufrgs.br
RI Schmidt, Maria/V-3196-2019; Duncan, Bruce/L-4140-2016
OI Duncan, Bruce/0000-0002-7491-2630
FU NIDDK NIH HHS [R01-DK56918] Funding Source: Medline
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NR 63
TC 77
Z9 87
U1 1
U2 9
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1520-9156
EI 1557-8593
J9 DIABETES TECHNOL THE
JI Diabetes Technol. Ther.
PD FEB
PY 2006
VL 8
IS 1
BP 7
EP 17
DI 10.1089/dia.2006.8.7
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 110TY
UT WOS:000242405200002
PM 16472046
DA 2025-06-11
ER

PT J
AU Lee, AA
   Gabriele, JM
AF Lee, Aaron A.
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TI Racial Differences in the Associations of Posttraumatic Stress and
   Insomnia With Body Mass Index Among Trauma-Exposed Veterans
SO BEHAVIORAL MEDICINE
LA English
DT Article
DE BMI; insomnia; PTSD; race; trauma
ID SHORT-SLEEP DURATION; RISK-FACTORS; WAIST CIRCUMFERENCE; METABOLIC
   SYNDROME; SEVERITY INDEX; ADULT OBESITY; UNITED-STATES; WEIGHT-GAIN;
   DSM-IV; DISORDER
AB Posttraumatic stress is associated with increased body mass index (BMI) and rates of obesity. Black adults are at greater risk for obesity, trauma exposure, development of posttraumatic stress disorder, and comorbid sleep problems compared to White adults. Accordingly, Black adults with a history of trauma exposure may be at greater risk for elevated BMI associated with posttraumatic stress and insomnia. Multiple linear regression was used to examine race as a moderator of the relationship between posttraumatic symptoms and insomnia with BMI in a sample of Black and White trauma-exposed Veterans (N = 171), controlling for age and sex. There was a significant interaction of race with PTSD (p = 0.042) and insomnia symptoms (p = 0.045) on BMI. Simple slopes showed a significant positive association of posttraumatic stress and BMI among Black (p = 0.003), but not White Veterans (p = 0.590). Similarly, insomnia was significantly associated with greater BMI for Black (p = 0.023), but not White Veterans (p = 0.496). Posttraumatic stress and insomnia may play a particularly important role in the development of weight related health problems among Black Veterans. Early identification and treatment of these symptoms may reduce the risk of obesity among this vulnerable population.
C1 [Lee, Aaron A.] VA Ctr Clin Management Res, Ann Arbor, MI USA.
   [Gabriele, Jeanne M.] GV Sonny Montgomery Vet Affairs Med Ctr, Jackson, MS USA.
RP Lee, AA (corresponding author), Univ Michigan, VA Ctr Clin Management Res, North Campus Res Complex,2800 Plymouth Rd, Ann Arbor, MI 48109 USA.
EM aaronlee@med.umich.edu
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NR 68
TC 4
Z9 5
U1 0
U2 9
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 0896-4289
EI 1940-4026
J9 BEHAV MED
JI Behav. Med.
PY 2018
VL 44
IS 4
BP 263
EP 270
DI 10.1080/08964289.2017.1292998
PG 8
WC Behavioral Sciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Behavioral Sciences; Psychiatry
GA GV6GM
UT WOS:000446206200001
PM 28323566
DA 2025-06-11
ER

PT J
AU Wang, J
   He, WP
   Tsai, PJ
   Chen, PH
   Ye, MX
   Guo, J
   Su, ZQ
AF Wang, Jin
   He, Wanping
   Tsai, Ping-Ju
   Chen, Pei-Hsuan
   Ye, Manxiang
   Guo, Jiao
   Su, Zhengquan
TI Mutual interaction between endoplasmic reticulum and mitochondria in
   nonalcoholic fatty liver disease
SO LIPIDS IN HEALTH AND DISEASE
LA English
DT Review
DE Endoplasmic reticulum stress; Non-alcoholic fatty liver disease;
   Mitochondria-associated membrane; Oxidative stress; Calcium ion
   homeostasis
ID DISRUPTS CALCIUM HOMEOSTASIS; UNFOLDED PROTEIN RESPONSE; INDUCED HEPATIC
   STEATOSIS; ER STRESS; MOLECULAR-MECHANISMS; LIPID-METABOLISM; MITOFUSIN
   2; INSULIN-RESISTANCE; MEMBRANES; STEATOHEPATITIS
AB Nonalcoholic fatty liver disease (NAFLD) is a common metabolic syndrome. Imbalances between liver lipid output and input are the direct causes of NAFLD, and hepatic steatosis is the pathological premise and basis for NAFLD progression. Mutual interaction between endoplasmic reticulum stress (ERS) and oxidative stress play important roles in NAFLD pathogenesis. Notably, mitochondria-associated membranes (MAMs) act as a structural bridges for functional clustering of molecules, particularly for Ca2+, lipids, and reactive oxygen species (ROS) exchange. Previous studies have examined the crucial roles of ERS and ROS in NAFLD and have shown that MAM structural and functional integrity determines normal ER- mitochondria communication. Upon disruption of MAM integrity, miscommunication directly or indirectly causes imbalances in Ca2+ homeostasis and increases ERS and oxidative stress. Here, we emphasize the involvement of MAMs in glucose and lipid metabolism, chronic inflammation and insulin resistance in NAFLD and summarize MAM-targeting drugs and compounds, most of which achieve their therapeutic or ameliorative effects on NAFLD by improving MAM integrity. Therefore, targeting MAMs may be a viable strategy for NAFLD treatment. This review provides new ideas and key points for basic NAFLD research and drug development centred on mitochondria and the endoplasmic reticulum.
C1 [Wang, Jin; He, Wanping; Su, Zhengquan] Guangdong Pharmaceut Univ, Guangdong Engn Res Ctr Nat Prod & New Drugs, Guangdong Prov Univ Engn Technol Res Ctr Nat Prod, Guangzhou 510006, Peoples R China.
   [Wang, Jin; He, Wanping; Guo, Jiao] Guangdong Pharmaceut Univ, Guangdong Metab Dis Res Ctr Integrated Chinese &, Key Lab Modulating Liver Treat Hyperlipemia SATCM, Guangdong TCM Key Lab Metab Dis,Lab Lipid Metab S, Level 3, Guangzhou 510006, Peoples R China.
   [Tsai, Ping-Ju; Chen, Pei-Hsuan] King Prebiot Biotechnol TW Co LTD, 2F-1,250 Zhongshan Rd, New Taipei 24446, Taiwan.
   [Ye, Manxiang] New Francisco Yunfu City Biotechnol Co Ltd, Yunfu City, Guangdong, Peoples R China.
C3 Guangdong Pharmaceutical University; Guangdong Pharmaceutical University
RP Su, ZQ (corresponding author), Guangdong Pharmaceut Univ, Guangdong Engn Res Ctr Nat Prod & New Drugs, Guangdong Prov Univ Engn Technol Res Ctr Nat Prod, Guangzhou 510006, Peoples R China.; Guo, J (corresponding author), Guangdong Pharmaceut Univ, Guangdong Metab Dis Res Ctr Integrated Chinese &, Key Lab Modulating Liver Treat Hyperlipemia SATCM, Guangdong TCM Key Lab Metab Dis,Lab Lipid Metab S, Level 3, Guangzhou 510006, Peoples R China.
EM gyguoyz@163.com; suzhq@scnu.edu.cn
RI Hung, Chun-Cheng/C-8661-2009
FU Science and Technology Planning Project of Yunfu, Guangdong, China
   [201702-9]; Guangdong Provincial University Engineering Technology
   Research Center of Natural Products and Drugs, China [2017GCZX002];
   Science and Technology Planning Project of Guangdong, China
   [201806040009, 201804010349, 201804010329]
FX This work was financially supported by the Science and Technology
   Planning Project of Yunfu, Guangdong, China (No. 201702-9); Guangdong
   Provincial University Engineering Technology Research Center of Natural
   Products and Drugs, China (No.2017GCZX002); and the Science and
   Technology Planning Project of Guangdong, China (No.201806040009,
   201804010349, 201804010329).
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NR 130
TC 102
Z9 110
U1 7
U2 46
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1476-511X
J9 LIPIDS HEALTH DIS
JI Lipids Health Dis.
PD APR 13
PY 2020
VL 19
IS 1
AR 72
DI 10.1186/s12944-020-01210-0
PG 19
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA LE7WI
UT WOS:000526934100005
PM 32284046
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Shi, H
   Deng, HX
   Gius, D
   Schumacker, PT
   Surmeier, DJ
   Ma, YC
AF Shi, Han
   Deng, Han-Xiang
   Gius, David
   Schumacker, Paul T.
   Surmeier, D. James
   Ma, Yong-Chao
TI Sirt3 protects dopaminergic neurons from mitochondrial oxidative stress
SO HUMAN MOLECULAR GENETICS
LA English
DT Article
ID MANGANESE SUPEROXIDE-DISMUTASE; SUBSTANTIA-NIGRA NEURONS; ATP SYNTHASE
   BETA; PARKINSONS-DISEASE; NIGROSTRIATAL DEGENERATION; METABOLIC
   SYNDROME; OXIDANT STRESS; DNA DELETIONS; MUTATIONS; DJ-1
AB Age-dependent elevation in mitochondrial oxidative stress is widely posited to be a major factor underlying the loss of substantia nigra pars compacta (SNc) dopaminergic neurons in Parkinson's disease (PD). However, mechanistic links between aging and oxidative stress are not well understood. Sirtuin-3 (Sirt3) is a mitochondrial deacetylase that could mediate this connection. Indeed, genetic deletion of Sirt3 increased oxidative stress and decreased the membrane potential of mitochondria in SNc dopaminergic neurons. This change was attributable to increased acetylation and decreased activity of manganese superoxide dismutase (MnSOD). Site directed mutagenesis of lysine 68 to glutamine (K68Q), mimicking acetylation, decreased MnSOD activity in SNc dopaminergic neurons, whereas mutagenesis of lysine 68 to arginine (K68R), mimicking deacetylation, increased activity. Introduction of K68R MnSOD rescued mitochondrial redox status and membrane potential of SNc dopaminergic neurons from Sirt3 knockouts. Moreover, deletion of DJ-1, which helps orchestrate nuclear oxidant defenses and Sirt3 in mice led to a clear age-related loss of SNc dopaminergic neurons. Lastly, K68 acetylation of MnSOD was significantly increased in the SNc of PD patients. Taken together, our studies suggest that an age-related decline in Sirt3 protective function is a major factor underlying increasing mitochondrial oxidative stress and loss of SNc dopaminergic neurons in PD.
C1 [Shi, Han; Ma, Yong-Chao] Northwestern Univ, Dept Pediat, Feinberg Sch Med, Anne & Robert H Lurie Childrens Hosp Chicago, Chicago, IL 60611 USA.
   [Shi, Han; Ma, Yong-Chao] Northwestern Univ, Dept Neurol, Feinberg Sch Med, Anne & Robert H Lurie Childrens Hosp Chicago, Chicago, IL 60611 USA.
   [Shi, Han; Ma, Yong-Chao] Northwestern Univ, Dept Physiol, Feinberg Sch Med, Anne & Robert H Lurie Childrens Hosp Chicago, Chicago, IL 60611 USA.
   [Deng, Han-Xiang] Northwestern Univ, Feinberg Sch Med, Ken & Ruth Davee Dept Neurol, Chicago, IL 60611 USA.
   [Gius, David] Northwestern Univ, Dept Radiol, Lurie Canc Inst, Feinberg Sch Med, Chicago, IL 60611 USA.
   [Schumacker, Paul T.] Northwestern Univ, Dept Pediat, Feinberg Sch Med, Chicago, IL 60611 USA.
   [Surmeier, D. James] Northwestern Univ, Dept Physiol, Feinberg Sch Med, Chicago, IL 60611 USA.
C3 Northwestern University; Feinberg School of Medicine; Ann & Robert H.
   Lurie Children's Hospital of Chicago; Ann & Robert H. Lurie Children's
   Hospital of Chicago; Northwestern University; Feinberg School of
   Medicine; Ann & Robert H. Lurie Children's Hospital of Chicago;
   Northwestern University; Feinberg School of Medicine; Northwestern
   University; Feinberg School of Medicine; Northwestern University;
   Feinberg School of Medicine; Robert H. Lurie Comprehensive Cancer
   Center; Northwestern University; Feinberg School of Medicine;
   Northwestern University; Feinberg School of Medicine
RP Ma, YC (corresponding author), Northwestern Univ, Dept Pediat, Feinberg Sch Med, Anne & Robert H Lurie Childrens Hosp Chicago, Chicago, IL 60611 USA.; Ma, YC (corresponding author), Northwestern Univ, Dept Neurol, Feinberg Sch Med, Anne & Robert H Lurie Childrens Hosp Chicago, Chicago, IL 60611 USA.; Ma, YC (corresponding author), Northwestern Univ, Dept Physiol, Feinberg Sch Med, Anne & Robert H Lurie Childrens Hosp Chicago, Chicago, IL 60611 USA.
EM ma@northwestern.edu
RI Shi, Han/AAM-4853-2021
OI Deng, Han-Xiang/0000-0002-0030-8465; Ma, Yongchao/0000-0002-2469-4356;
   Gius, David/0000-0001-9647-3571; Schumacker, Paul T/0000-0001-9591-2034
FU National Institutes of Health [AG043970, R01NS094564, 2R01CA152601-A1,
   1R01CA152799-01A1, 1R01CA168292-01A1, 1R01CA214025-01, NS047085];
   Hartwell Foundation; Chicago Biomedical Consortium; Whitehall
   Foundation; Joseph and Bessie Feinberg Foundation; Zell Family
   Foundation; Lynn Sage Foundation; Avon Foundation; Searle Funds at The
   Chicago Community Trust; JPB Foundation
FX This work was supported by National Institutes of Health (grant numbers
   AG043970 and R01NS094564) and grants from The Hartwell Foundation, the
   Chicago Biomedical Consortium and Whitehall Foundation to Y.C.M. Y.C.M.
   is Ann Marie and Francis Klocke M.D. Research Scholar supported by the
   Joseph and Bessie Feinberg Foundation. D.G. is supported by National
   Institutes of Health (grant numbers 2R01CA152601-A1, 1R01CA152799-01A1,
   1R01CA168292-01A1, 1R01CA214025-01), the Chicago Biomedical Consortium,
   Zell Family Foundation, the Lynn Sage Foundation, the Avon Foundation
   and the Searle Funds at The Chicago Community Trust. D.J.S. is supported
   by National Institutes of Health (grant number NS047085) and JPB
   Foundation.
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NR 52
TC 80
Z9 88
U1 1
U2 6
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0964-6906
EI 1460-2083
J9 HUM MOL GENET
JI Hum. Mol. Genet.
PD MAY 15
PY 2017
VL 26
IS 10
BP 1915
EP 1926
DI 10.1093/hmg/ddx100
PG 12
WC Biochemistry & Molecular Biology; Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Genetics & Heredity
GA EV8DK
UT WOS:000402010500011
PM 28369333
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Arab, A
   Mostafalou, S
AF Arab, Ali
   Mostafalou, Sara
TI Pesticides and insulin resistance-related metabolic diseases: Evidences
   and mechanisms
SO PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
LA English
DT Article
DE Chronic kidney disease; Diabetes; Hypertension; Insulin resistance;
   Metabolic syndrome; Obesity; Pesticide; Polycystic ovary syndrome
ID PERSISTENT ORGANIC POLLUTANTS; NUTRITION EXAMINATION SURVEY;
   POLYCYSTIC-OVARY-SYNDROME; BODY-MASS INDEX; ORGANOCHLORINE PESTICIDES;
   POLYCHLORINATED-BIPHENYLS; URINARY CONCENTRATIONS; SERUM CONCENTRATIONS;
   ADIPOSE-TISSUE; DICHLOROPHENOL PESTICIDES
AB The use of pesticides in the past century has lot helped humankind in improving crops' field and general hygiene level. Nevertheless, there has been countless evidences on the toxic effects of pesticides on the living systems. The link of exposure to pesticides with different human chronic diseases in the context of carcinogenicity, neurotoxicity, developmental toxicity, etc., have been evaluated in various types of studies. There are also some evidences on the link of exposure to pesticides with higher incidence of metabolic diseases associated with insulin resistance like diabetes, obesity, metabolic syndrome, hypertension, polycystic ovary syndrome and chronic kidney diseases. Physiologically, weakening intracellular insulin signaling is considered as a compensatory mechanism for cells to cope with cellular stresses like xenobiotic effects, oxidative stress and inflammatory responses, but it can pathologically lead to a defective cycle with lowered sensitivity of the cells to insulin which happens in metabolic disorders. In this work, the data related to metabolic toxicity of pesticides categorized in the mentioned metabolic diseases with a focus on the effects of pesticides on insulin signaling pathway and the mechanisms of development of insulin resistance will be systematically reviewed and presented.
C1 [Arab, Ali; Mostafalou, Sara] Ardabil Univ Med Sci, Sch Pharm, Dept Pharmacol & Toxicol, Ardebil, Iran.
   [Mostafalou, Sara] Ardabil Univ Med Sci, Sch Pharm, Dept Pharmacol & Toxicol, Ardebil 5618953141, Iran.
C3 Ardabil University of Medical Sciences; Ardabil University of Medical
   Sciences
RP Mostafalou, S (corresponding author), Ardabil Univ Med Sci, Sch Pharm, Dept Pharmacol & Toxicol, Ardebil 5618953141, Iran.
EM s.mostafalou@arums.ac.ir
RI Arab, Ali/KFA-3733-2024; Mostafalou, Sara/I-3151-2017
OI Arab, Ali/0000-0002-4601-6978
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NR 102
TC 11
Z9 11
U1 2
U2 16
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0048-3575
EI 1095-9939
J9 PESTIC BIOCHEM PHYS
JI Pest. Biochem. Physiol.
PD SEP
PY 2023
VL 195
AR 105521
DI 10.1016/j.pestbp.2023.105521
EA JUL 2023
PG 12
WC Biochemistry & Molecular Biology; Entomology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Entomology; Physiology
GA P1IS5
UT WOS:001048251800001
PM 37666627
DA 2025-06-11
ER

PT J
AU Nunes, AR
   Alves, G
   Falcao, A
   Lopes, JA
   Silva, LR
AF Nunes, Ana R.
   Alves, Gilberto
   Falcao, Amilcar
   Lopes, Joao A.
   Silva, Luis R.
TI Phenolic Acids from Fruit By-Products as Therapeutic Agents for
   Metabolic Syndrome: A Review
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE by-products; bioactive compounds; metabolic health; valorization;
   biological properties
ID FERULIC ACID; INSULIN-RESISTANCE; OXIDATIVE STRESS; CHLOROGENIC ACID;
   ELLAGIC ACID; IN-VITRO; PANCREATIC LIPASE; GLUCOSE-UPTAKE; CAFFEIC ACID;
   APPLE SEEDS
AB The cultivation and processing of fruits generate a wide range of by-products (e.g., pulp, seeds, pomace, leaves, and stems), which are often underutilized despite being rich sources of phenolic compounds with well-documented bioactive properties. The bioactive potential of these compounds has attracted significant interest from both the pharmaceutical and food sectors, offering opportunities for their use in functional foods, dietary supplements, natural medicines, and additives. Among these, phenolic acids have shown promising potential in modulating risk factors associated with metabolic syndrome (MetS), a condition encompassing hypertension, dyslipidemia, hyperglycemia, and abdominal obesity, and contributing significantly to cardiovascular disease. Given the global burden of MetS and the need for novel preventive strategies, numerous studies have investigated the bioactivity of phenolic acids derived from fruit by-products. In this review, we critically examine recent studies regarding the phenolic acid composition of fruit-derived by-products and their biological activity in relation to MetS-related risk factors. This work aims to synthesize current findings, highlight prevailing research trends, and identify existing gaps in the literature to inform future research and promote the sustainable use of fruit by-products in the prevention and management of MetS.
C1 [Nunes, Ana R.; Alves, Gilberto; Silva, Luis R.] Univ Beira Interior, Fac Hlth Sci, RISE Hlth Dept Med Sci, Ave Infante D Henrique, P-6200506 Covilha, Portugal.
   [Nunes, Ana R.] Univ Coimbra, Fac Med, CNC Ctr Neurosci & Cell Biol, P-3004504 Coimbra, Portugal.
   [Falcao, Amilcar] Univ Coimbra, Fac Pharm, Lab Pharmacol, P-3000548 Coimbra, Portugal.
   [Falcao, Amilcar] Univ Coimbra, CIBIT Coimbra Inst Biomed Imaging & Translat Res, P-3000548 Coimbra, Portugal.
   [Lopes, Joao A.] Univ Lisbon, Res Inst Med, Fac Farm, iMed ULisboa, P-1649003 Lisbon, Portugal.
   [Silva, Luis R.] Polytech Inst Guarda, Ctr Potential & Innovat Nat Resources, CPIRN UDI IPG, P-6300559 Guarda, Portugal.
   [Silva, Luis R.] Univ Coimbra, Dept Chem Engn, CERES UC, P-3030790 Coimbra, Portugal.
C3 Universidade da Beira Interior; Universidade de Coimbra; Universidade de
   Coimbra; Universidade de Coimbra; Universidade de Lisboa; Instituto
   Politecnico da Guarda; Universidade de Coimbra
RP Silva, LR (corresponding author), Univ Beira Interior, Fac Hlth Sci, RISE Hlth Dept Med Sci, Ave Infante D Henrique, P-6200506 Covilha, Portugal.; Silva, LR (corresponding author), Polytech Inst Guarda, Ctr Potential & Innovat Nat Resources, CPIRN UDI IPG, P-6300559 Guarda, Portugal.; Silva, LR (corresponding author), Univ Coimbra, Dept Chem Engn, CERES UC, P-3030790 Coimbra, Portugal.
EM araqueln@gmail.com; gilberto@fcsaude.ubi.pt; acfalcao@ff.uc.pt;
   jlopes@ff.ulisboa.pt; luissilva@ipg.pt
RI Silva, Luís/D-5485-2013
FU Foundation for Science and Technology (FCT); CICS-UBI
   [PRR-C05-i03-I-000143]; National funds included in the budget of the
   Foundation for Science and Technology (FCT); La Caixa Foundation
   [PD21-00023, SFRH/BD/139137/2018]; FCT under the Programa Promove
   Project
FX This research was funded by base funding from CICS-UBI
   (https://doi.org/10.54499/UIDB/00709/2020) and programmatic funding
   (https://doi.org/10.54499/UIDP/00709/2020) with national funds included
   in the budget of the Foundation for Science and Technology (FCT). It was
   also supported by project PRR-C05-i03-I-000143 (RedFruit4Health), by La
   Caixa Foundation, and by the FCT under the Programa Promove Project
   PD21-00023 (PharmaStar). Financial support from the FCT was also
   provided to ARN [SFRH/BD/139137/2018].
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NR 169
TC 0
Z9 0
U1 1
U2 1
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD APR 18
PY 2025
VL 26
IS 8
AR 3834
DI 10.3390/ijms26083834
PG 31
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 1WJ9T
UT WOS:001475242700001
PM 40332518
DA 2025-06-11
ER

PT J
AU Souza, BSFE
   Carvalho, HO
   Taglialegna, T
   Barros, ASA
   da Cunha, EL
   Ferreira, IM
   Keita, H
   Navarrete, A
   Carvalho, JCT
AF Faria e Souza, Belmira S.
   Carvalho, Helison O.
   Taglialegna, Talisson
   Barros, Albenise Santana A.
   da Cunha, Edilson Leal
   Ferreira, Irlon Maciel
   Keita, Hady
   Navarrete, Andres
   Tavares Carvalho, Jose Carlos
TI Effect of Euterpe oleracea Mart. (Acai) Oil on Dyslipidemia
   Caused by Cocos nucifera L. Saturated Fat in Wistar Rats
SO JOURNAL OF MEDICINAL FOOD
LA English
DT Article
DE Acai; atherosclerosis; Cocos nucifera L; dyslipidemia; Euterpe oleracea
   Mart.; fatty acids; oil
ID METABOLIC SYNDROME; BRAZILIAN GUIDELINES; OXIDATIVE STRESS;
   ATHEROSCLEROSIS; PREVENTION; EXTRACT
AB Dyslipidemia is caused by disturbances in lipid metabolism that lead to chronic elevations of serum lipids, especially low-density lipoprotein (LDL)-cholesterol and triglycerides, increasing the risk of metabolic syndrome, obesity, diabetes, atherogenic processes, and cardiovascular diseases. The oil from the fruits of Euterpe oleracea (OFEO) is rich in unsaturated fatty acids with potential for treating alterations in lipid metabolism. In this study, we aimed to investigate the effect of OFEO on hyperlipidemia induced by Cocos nucifera L. saturated fat (GSC) in Wistar rats. Chromatographic profile showed that unsaturated fatty acids account for 66.08% in OFEO, predominately oleic acid (54.30%), and saturated fatty acids (palmitic acid 31.6%) account for 33.92%. GSC-induced dyslipidemia resulted in an increase in total cholesterol, LDL-cholesterol, triglycerides, glucose, and liver and abdominal fat, as well as atherogenic processes in the thoracic aorta. OFEO treatment did not reduce hypertriglyceridemia, but did reduce total cholesterol and LDL-cholesterol, thus contributing to the antiatherogenic action of OFEO. OFEO treatment inhibited the formation of atheromatous plaques in the vascular endothelium of the treated rats, as well as those who were treated with simvastatin. The results obtained suggest that OFEO has an antiatherogenic effect in a rat model of dyslipidemia.
C1 [Faria e Souza, Belmira S.; Carvalho, Helison O.; Taglialegna, Talisson; Barros, Albenise Santana A.; da Cunha, Edilson Leal; Keita, Hady; Tavares Carvalho, Jose Carlos] Univ Fed Amapa, Coll Pharm, Dept Biol Sci & Hlth, Drug Res Lab, Rod JK,KM 02, BR-68902280 Macapa, Brazil.
   [Faria e Souza, Belmira S.; da Cunha, Edilson Leal] Univ Fed Amapa, Coll Pharm, Dept Biol Sci & Hlth, Grad Program Pharmaceut Innovat, Macapa, Brazil.
   [Carvalho, Helison O.] Univ Fed Amapa, Dept Biol Sci & Hlth, Sch Sci Degree Program, Macapa, Brazil.
   [Ferreira, Irlon Maciel] Univ Fed Amapa, Dept Chem, Biocatal & Biotransformat Lab Organ Chem, Macapa, Brazil.
   [Navarrete, Andres] Univ Nacl Autonoma Mexico, Dept Pharm, Fac Chem, Pharmacol Nat Prod Lab, Mexico City, DF, Mexico.
C3 Fundacao Universidade Federal do Amapa; Fundacao Universidade Federal do
   Amapa; Fundacao Universidade Federal do Amapa; Fundacao Universidade
   Federal do Amapa; Universidad Nacional Autonoma de Mexico
RP Carvalho, JCT (corresponding author), Univ Fed Amapa, Coll Pharm, Dept Biol Sci & Hlth, Drug Res Lab, Rod JK,KM 02, BR-68902280 Macapa, Brazil.
EM farmacos@unifap.br
RI Carvalho, Jose Carlos/S-2427-2019; Carvalho, Helison/IQT-9898-2023;
   Ferreira, Irlon/ITT-4781-2023; Navarrete, Andres/ABB-6148-2020
OI FERREIRA, IRLON/0000-0002-4517-0105
FU National Council for Scientific, Technological Development-CNPq
   [402332/2013-0]; Universidad Autonoma de Mexico - Programa de Estancias
   de Investigacion (PREI)
FX This study was supported by National Council for Scientific,
   Technological Development-CNPq (Biotec-Process 402332/2013-0), and
   Universidad Autonoma de Mexico - Programa de Estancias de Investigacion
   (PREI).
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NR 42
TC 10
Z9 10
U1 0
U2 10
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1096-620X
EI 1557-7600
J9 J MED FOOD
JI J. Med. Food
PD SEP
PY 2017
VL 20
IS 9
BP 830
EP 837
DI 10.1089/jmf.2017.0027
PG 8
WC Chemistry, Medicinal; Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Food Science & Technology; Nutrition &
   Dietetics
GA FG3MX
UT WOS:000410070100002
PM 28731787
DA 2025-06-11
ER

PT J
AU Lam, DCL
   Xu, A
   Lam, KSL
   Lam, B
   Lam, JCM
   Lui, MMS
   Ip, MSM
AF Lam, D. C-L.
   Xu, A.
   Lam, K. S-L.
   Lam, B.
   Lam, J. C-M.
   Lui, M-M-S.
   Ip, M. S-M.
TI Serum adipocyte-fatty acid binding protein level is elevated in severe
   OSA and correlates with insulin resistance
SO EUROPEAN RESPIRATORY JOURNAL
LA English
DT Article
DE Adipocyte-fatty acid binding protein; obstructive sleep apnoea
ID OBSTRUCTIVE SLEEP-APNEA; METABOLIC SYNDROME; GLUCOSE-METABOLISM;
   APOLIPOPROTEIN-E; AP2; OBESITY; EXPRESSION; DEFICIENT; STRESS;
   ATHEROSCLEROSIS
AB Obstructive sleep apnoea (OSA) is associated with insulin resistance and metabolic syndrome. There is evidence that adipocyte-fatty acid binding protein (A-FABP) may be involved in the development of cardiometabolic dysfunction. The present authors hypothesise that A-FABP is upregulated in OSA.
   A total of 124 males without hypertension, diabetes mellitus, hyperlipidaemia or cardiovascular disease were recruited and underwent polysomnography. Serum A-FABP levels showed significant positive correlations with duration of oxygen desaturation and minimal oxygen saturation, fasting insulin and insulin resistance index by homeostasis model assessment. When subjects were divided into tertiles according to apnoea/hypopnoea index (AHI), serum A-FABP levels were significantly higher in the group with AHI >= 34.4 events.h(-1) than the groups with AHI 13.2-34.4 events.h(-1) or with AHI <13.2 events.h(-1). Serum A-FABP levels were significantly higher in the AHI >= 34.4 group than obesity-matched subjects with AHI <34.4 events.h(-1).
   Serum adipocyte-fatty acid binding protein levels correlated with obstructive sleep apnoea and insulin resistance, independently of obesity, and were significantly higher in severe obstructive sleep apnoea. Adipocyte-fatty acid binding protein may play a role in obstructive sleep apnoea and metabolic dysfunction.
C1 [Lam, D. C-L.; Xu, A.; Lam, K. S-L.; Lam, B.; Lam, J. C-M.; Lui, M-M-S.; Ip, M. S-M.] Univ Hong Kong, Dept Med, Hong Kong, Hong Kong, Peoples R China.
   [Xu, A.; Lam, K. S-L.; Ip, M. S-M.] Univ Hong Kong, Res Ctr Heart Brain Hormone & Healthy Aging, Hong Kong, Hong Kong, Peoples R China.
C3 University of Hong Kong; University of Hong Kong
RP Ip, MSM (corresponding author), Univ Hong Kong, Queen Mary Hosp, Univ Dept Med, 102 Pokfulam Rd, Hong Kong, Hong Kong, Peoples R China.
EM msmip@hkucc.hku.hk
RI Lam, David/AAI-3657-2020; Lam, Jason/KYP-4593-2024; Xu,
   Aimin/D-3291-2013; /E-9868-2010; Ip, Mary Sau Man/C-4284-2009
OI Lui, Macy/0000-0002-7150-9360; /0000-0002-0004-2660; Ip, Mary Sau
   Man/0000-0002-8692-6933
FU Research Grants Council (RGC) Earmarked Competitive Grant award
   [7667/07M]; RGC Central Allocation [HKU 2/07C]; Lee Wing Tat
   Cardiorespiratory Research Fund
FX This study was jointly supported by the Research Grants Council (RGC)
   Earmarked Competitive Grant award 7667/07M, the RGC Central Allocation
   Grant (HKU 2/07C) and the Lee Wing Tat Cardiorespiratory Research Fund.
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NR 30
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Z9 34
U1 0
U2 2
PU EUROPEAN RESPIRATORY SOC JOURNALS LTD
PI SHEFFIELD
PA 442 GLOSSOP RD, SHEFFIELD S10 2PX, ENGLAND
SN 0903-1936
EI 1399-3003
J9 EUR RESPIR J
JI Eur. Resp. J.
PD FEB
PY 2009
VL 33
IS 2
BP 346
EP 351
DI 10.1183/09031936.50075408
PG 6
WC Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Respiratory System
GA 412FK
UT WOS:000263709300018
PM 19181913
OA Bronze
DA 2025-06-11
ER

PT J
AU Arabshomali, A
   Bazzazzadehgan, S
   Mahdi, F
   Shariat-Madar, Z
AF Arabshomali, Arman
   Bazzazzadehgan, Shadi
   Mahdi, Fakhri
   Shariat-Madar, Zia
TI Potential Benefits of Antioxidant Phytochemicals in Type 2 Diabetes
SO MOLECULES
LA English
DT Review
DE oxidative stress; reactive oxygen and nitrogen species; redox state;
   antioxidant response; diabetes; metabolic syndrome; inflammation
ID NF-KAPPA-B; ENDOPLASMIC-RETICULUM-STRESS; PROTEIN-KINASE-C;
   OXIDATIVE-STRESS; ANGIOTENSIN-II; CARDIOVASCULAR-DISEASE; INFLAMMATORY
   RESPONSES; DIETARY SUPPLEMENTATION; GLUCOSE-HOMEOSTASIS; SIGNALING
   PATHWAYS
AB The clinical relationship between diabetes and inflammation is well established. Evidence clearly indicates that disrupting oxidant-antioxidant equilibrium and elevated lipid peroxidation could be a potential mechanism for chronic kidney disease associated with type 2 diabetes mellitus (T2DM). Under diabetic conditions, hyperglycemia, especially inflammation, and increased reactive oxygen species generation are bidirectionally associated. Inflammation, oxidative stress, and tissue damage are believed to play a role in the development of diabetes. Although the exact mechanism underlying oxidative stress and its impact on diabetes progression remains uncertain, the hyperglycemia-inflammation-oxidative stress interaction clearly plays a significant role in the onset and progression of vascular disease, kidney disease, hepatic injury, and pancreas damage and, therefore, holds promise as a therapeutic target. Evidence strongly indicates that the use of multiple antidiabetic medications fails to achieve the normal range for glycated hemoglobin targets, signifying treatment-resistant diabetes. Antioxidants with polyphenols are considered useful as adjuvant therapy for their potential anti-inflammatory effect and antioxidant activity. We aimed to analyze the current major points reported in preclinical, in vivo, and clinical studies of antioxidants in the prevention or treatment of inflammation in T2DM. Then, we will share our speculative vision for future diabetes clinical trials.
C1 [Arabshomali, Arman; Bazzazzadehgan, Shadi] Univ Mississippi, Sch Pharm, Dept Pharm Adm, University, MS 38677 USA.
   [Mahdi, Fakhri; Shariat-Madar, Zia] Univ Mississippi, Sch Pharm, Dept BioMol Sci, Div Pharmacol, University, MS 38677 USA.
C3 University of Mississippi; University of Mississippi
RP Shariat-Madar, Z (corresponding author), Univ Mississippi, Sch Pharm, Dept BioMol Sci, Div Pharmacol, University, MS 38677 USA.
EM marabsho@go.olemiss.edu; sbazzazz@go.olemiss.edu; fmahdi@olemiss.edu;
   madar@olemiss.edu
RI Arabshomali, Arman/MBW-1676-2025
OI Mahdi, Fakhri/0000-0003-4891-2992; Bazzazzadehgan,
   Shadi/0000-0002-1407-4727; Arabshomali, Arman/0000-0001-7243-6573
FU University of Mississippi
FX This work was supported by the University of Mississippi to Z.S.-M.
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NR 262
TC 23
Z9 23
U1 0
U2 14
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 1420-3049
J9 MOLECULES
JI Molecules
PD OCT
PY 2023
VL 28
IS 20
AR 7209
DI 10.3390/molecules28207209
PG 29
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA X0JH1
UT WOS:001095395100001
PM 37894687
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Stanciu, SM
   Jinga, M
   Miricescu, D
   Stefani, C
   Nica, RI
   Stanescu-Spinu, II
   Vacaroiu, IA
   Greabu, M
   Nica, S
AF Stanciu, Silviu Marcel
   Jinga, Mariana
   Miricescu, Daniela
   Stefani, Constantin
   Nica, Remus Iulian
   Stanescu-Spinu, Iulia-Ioana
   Vacaroiu, Ileana Adela
   Greabu, Maria
   Nica, Silvia
TI mTOR Dysregulation, Insulin Resistance, and Hypertension
SO BIOMEDICINES
LA English
DT Review
DE sedentarism; obesity; insulin resistance; protein kinases; mTOR
   dysregulation; metformin; inhibitors
ID ANGIOTENSIN-ALDOSTERONE SYSTEM; SALT-INDUCED HYPERTENSION; TYPE-2
   DIABETES-MELLITUS; METABOLIC SYNDROME; SIGNALING PATHWAY; MAMMALIAN
   TARGET; GLUCOSE-METABOLISM; OXIDATIVE-STRESS; PROTECTIVE ROLE; MOUSE
   MODELS
AB Worldwide, diabetes mellitus (DM) and cardiovascular diseases (CVDs) represent serious health problems associated with unhealthy diet and sedentarism. Metabolic syndrome (MetS) is characterized by obesity, dyslipidemia, hyperglycemia, insulin resistance (IR) and hypertension. The mammalian target of rapamycin (mTOR) is a serine/threonine kinase with key roles in glucose and lipid metabolism, cell growth, survival and proliferation. mTOR hyperactivation disturbs glucose metabolism, leading to hyperglycemia and further to IR, with a higher incidence in the Western population. Metformin is one of the most used hypoglycemic drugs, with anti-inflammatory, antioxidant and antitumoral properties, having also the capacity to inhibit mTOR. mTOR inhibitors such as rapamycin and its analogs everolimus and temsirolimus block mTOR activity, decrease the levels of glucose and triglycerides, and reduce body weight. The link between mTOR dysregulation, IR, hypertension and mTOR inhibitors has not been fully described. Therefore, the main aim of this narrative review is to present the mechanism by which nutrients, proinflammatory cytokines, increased salt intake and renin-angiotensin-aldosterone system (RAAS) dysregulation induce mTOR overactivation, associated further with IR and hypertension development, and also mTOR inhibitors with higher potential to block the activity of this protein kinase.
C1 [Stanciu, Silviu Marcel; Jinga, Mariana] Carol Davila Univ Med & Pharm, Cent Mil Emergency Univ Hosp Dr Carol Davila, Dept Internal Med & Gastroenterol, Bucharest 010825, Romania.
   [Miricescu, Daniela; Greabu, Maria] Carol Davila Univ Med & Pharm, Discipline Biochem, Fac Dent, 8 Eroii Sanit Blvd, Bucharest 050474, Romania.
   [Stefani, Constantin] Cent Mil Emergency Univ Hosp Dr Carol Davila, Dept Family Med & Clin Base, Bucharest 010825, Romania.
   [Nica, Remus Iulian] Cent Mil Emergency Univ Hosp Dr Carol Davila, Surg Dept, Bucharest 010825, Romania.
   [Nica, Remus Iulian] Carol Davila Univ Med & Pharm, Discipline Gen Surg, 8 Eroii Sanotari Blvd, Bucharest 054474, Romania.
   [Stanescu-Spinu, Iulia-Ioana] Carol Davila Univ Med & Pharm, Discipline Physiol, Fac Dent, 8 Eroii Sanit Blvd, Bucharest 050474, Romania.
   [Vacaroiu, Ileana Adela] Carol Davila Univ Med & Pharm, Fac Med, Dept Nephrol, Bucharest 020021, Romania.
   [Nica, Silvia] Univ Hosp Bucharest, Emergency Discipline, Bucharest 050098, Romania.
   [Nica, Silvia] Carol Davila Univ Med & Pharm, Dept Emergency & First Aid, 8 Eroii Sanit Blvd, Bucharest 050474, Romania.
C3 Carol Davila University of Medicine & Pharmacy; Carol Davila University
   of Medicine & Pharmacy; Carol Davila University of Medicine & Pharmacy;
   Carol Davila University of Medicine & Pharmacy; Carol Davila University
   of Medicine & Pharmacy; Carol Davila University of Medicine & Pharmacy
RP Miricescu, D (corresponding author), Carol Davila Univ Med & Pharm, Discipline Biochem, Fac Dent, 8 Eroii Sanit Blvd, Bucharest 050474, Romania.; Stanescu-Spinu, II (corresponding author), Carol Davila Univ Med & Pharm, Discipline Physiol, Fac Dent, 8 Eroii Sanit Blvd, Bucharest 050474, Romania.
EM silviu.stanciu@umfcd.ro; mariana.jinga@umfcd.ro;
   daniela.miricescu@umfcd.ro; constantin.stefani@umfcd.ro;
   remus.nica@umfcd.ro; iulia.stanescu@umfcd.ro; ileana.vacaroiu@umfcd.ro;
   maria.greabu@umfcd.ro; silvia.nica@umfcd.ro
RI Daniela, Miricescu/G-8788-2016; Nica, Remus/HGE-3025-2022; Greabu,
   Maria/Q-9336-2019; Vacaroiu, Ileana/AAL-6901-2021; Nica,
   Silvia/HGE-8305-2022; STANCIU, Silviu/HJY-0379-2023; Jinga,
   Mariana/AAA-7101-2022; Stanescu-Spinu, Iulia-Ioana/AAD-7140-2021
OI Jinga, Mariana/0000-0001-5826-0815; Stanescu-Spinu,
   Iulia-Ioana/0000-0001-9224-6056
FU University of Medicine and Pharmacy Carol Davila
FX The publication of this paper was supported by the University of
   Medicine and Pharmacy Carol Davila, through the institutional program
   Publish not Perish.
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NR 171
TC 2
Z9 2
U1 3
U2 4
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2227-9059
J9 BIOMEDICINES
JI Biomedicines
PD AUG
PY 2024
VL 12
IS 8
AR 1802
DI 10.3390/biomedicines12081802
PG 18
WC Biochemistry & Molecular Biology; Medicine, Research & Experimental;
   Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Research & Experimental Medicine;
   Pharmacology & Pharmacy
GA E7Y7A
UT WOS:001305127500001
PM 39200267
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Tellechea, ML
   Mensegue, MF
   Pirola, CJ
AF Tellechea, Mariana L.
   Mensegue, Melisa F.
   Pirola, Carlos J.
TI The Association between High Fat Diet around Gestation and Metabolic
   Syndrome-related Phenotypes in Rats: A Systematic Review and
   Meta-Analysis
SO SCIENTIFIC REPORTS
LA English
DT Article
ID LINOLEIC-ACID SUPPLEMENTATION; MATERNAL OBESITY; LEPTIN SENSITIVITY;
   SATURATED-FAT; OXIDATIVE STRESS; MILK-COMPOSITION; GENE-EXPRESSION; RICH
   DIET; ENDOTHELIAL DYSFUNCTION; DEVELOPMENTAL ORIGINS
AB Numerous rodent studies have evaluated the effects of a maternal high-fat diet (HFD) on later in life susceptibility to Metabolic Syndrome (MetS) with varying results. Our aim was to quantitatively synthesize the available data on effects of maternal HFD around gestation on offspring's body mass, body fat, plasma leptin, glucose, insulin, lipids and systolic blood pressure (SBP). Literature was screened and summary estimates of the effect of maternal HFD on outcomes were calculated by using fixed-or random-effects models. 362 effect sizes from 68 studies together with relevant moderators were collected. We found that maternal HFD is statistically associated with higher body fat, body weight, leptin, glucose, insulin and triglycerides levels, together with increased SBP in offspring later in life. Our analysis also revealed non-significant overall effect on offspring's HDL-cholesterol. A main source of variation among studies emerged from rat strain and lard-based diet type. Strain and sex -specific effects on particular data subsets were detected. Recommendations are suggested for future research in the field of developmental programming of the MetS. Despite significant heterogeneity, our meta-analysis confirms that maternal HFD had long-term metabolic effects in offspring.
C1 [Tellechea, Mariana L.; Mensegue, Melisa F.; Pirola, Carlos J.] Univ Buenos Aires, Inst Med Res A Lanari, Buenos Aires, DF, Argentina.
   [Tellechea, Mariana L.; Mensegue, Melisa F.; Pirola, Carlos J.] Univ Buenos Aires, CONICET, Natl Sci & Tech Res Council, Inst Med Res IDIM,Dept Mol Genet & Biol Complex D, Buenos Aires, DF, Argentina.
C3 University of Buenos Aires; Consejo Nacional de Investigaciones
   Cientificas y Tecnicas (CONICET); University of Buenos Aires
RP Mensegue, MF; Pirola, CJ (corresponding author), Univ Buenos Aires, Inst Med Res A Lanari, Buenos Aires, DF, Argentina.; Mensegue, MF; Pirola, CJ (corresponding author), Univ Buenos Aires, CONICET, Natl Sci & Tech Res Council, Inst Med Res IDIM,Dept Mol Genet & Biol Complex D, Buenos Aires, DF, Argentina.
EM mariana.tellechea@conicet.gov.ar; pirola.carlos@lanari.fmed.uba.ar
RI TELLECHEA, MARIANA/AAM-6673-2021; Pirola, Carlos/H-2720-2019
OI TELLECHEA, MARIANA LORENA/0000-0002-1194-8433
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NR 102
TC 39
Z9 41
U1 0
U2 8
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD JUL 11
PY 2017
VL 7
AR 5086
DI 10.1038/s41598-017-05344-7
PG 18
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA FA1BI
UT WOS:000405172600053
PM 28698653
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Di Pierro, F
   Bressan, A
   Ranaldi, D
   Rapacioli, G
   Giacomelli, L
   Bertuccioli, A
AF Di Pierro, F.
   Bressan, A.
   Ranaldi, D.
   Rapacioli, G.
   Giacomelli, L.
   Bertuccioli, A.
TI Potential role of bioavailable curcumin in weight loss and omental
   adipose tissue decrease: preliminary data of a randomized, controlled
   trial in overweight people with metabolic syndrome. Preliminary study
SO EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
LA English
DT Article
DE Curcumin phytosome; Phosphatidylserine; White adipose tissue
ID OXIDATIVE STRESS; CANCER CELLS; OBESITY; METAANALYSIS; MICE; RAT;
   EXPRESSION; CORTISOL; DISEASE; AGENTS
AB OBJECTIVE: This randomized, controlled study aims to evaluate the tolerability and the efficacy of curcumin in overweight subjects affected from metabolic syndrome, with a focus on impaired glucose intolerance and android-type fat accumulation.
   PATIENTS AND METHODS: Forty-four subjects, selected among those who after 30 days of diet and intervention lifestyle have shown a weight loss < 2%, have been treated for further 30 days either with curcumin complexed with phosphatidylserine in phytosome form or with pure phosphatidylserine. Outcomes concerning anthropometric measurements and body composition were analyzed at enrollment and after 30 and 60 days.
   RESULTS: Curcumin administration increased weight loss from 1.88 to 4.91%, enhanced percentage reduction of body fat (from 0.70 to 8.43%), increased waistline reduction (from 2.36 to 4.14%), improved hip circumference reduction from 0.74 to 2.51% and enhanced reduction of BMI (from 2.10 to 6.43%) (p < 0.01 for all comparisons). Phosphatidylserine did not show any statistical significant effect. Tolerability was very good for both treatments, and no drop-out was reported.
   CONCLUSIONS: Although preliminary, our findings suggest that a bioavailable form of curcumin is well-tolerated and can positively influence weight management in overweight people.
C1 [Di Pierro, F.] Velleja Res, Milan, Italy.
   [Bressan, A.] ASUR Area 1, Pesaro, Italy.
   [Ranaldi, D.] Pharmextracta, Pontenure, Italy.
   [Rapacioli, G.] AIOR, Piacenza, Italy.
   [Giacomelli, L.] Univ Genoa, Sch Med, Dept Surg Sci & Integrated Diagnost, Genoa, Italy.
   [Bertuccioli, A.] AIFeM, Ravenna, Italy.
C3 University of Genoa
RP Di Pierro, F (corresponding author), Velleja Res, Milan, Italy.
EM f.dipierro@vellejaresearch.com
RI Bertuccioli, Alexander/AAA-1762-2022; Giacomelli, Luca/K-2489-2018
OI Giacomelli, Luca/0000-0002-5393-9340; Bertuccioli,
   Alexander/0000-0002-3922-9115
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NR 43
TC 104
Z9 111
U1 1
U2 12
PU VERDUCI PUBLISHER
PI ROME
PA VIA GREGORIO VII, ROME, 186-00165, ITALY
SN 1128-3602
J9 EUR REV MED PHARMACO
JI Eur. Rev. Med. Pharmacol. Sci.
PD NOV
PY 2015
VL 19
IS 21
BP 4195
EP 4202
PG 8
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA CY0MT
UT WOS:000366100900032
PM 26592847
DA 2025-06-11
ER

PT J
AU Kanagasabai, T
   Ardern, CI
AF Kanagasabai, Thirumagal
   Ardern, Chris I.
TI Inflammation, Oxidative Stress, and Antioxidants Contribute to Selected
   Sleep Quality and Cardiometabolic Health Relationships: A
   Cross-Sectional Study
SO MEDIATORS OF INFLAMMATION
LA English
DT Article
ID C-REACTIVE PROTEIN; HORMONE-BINDING GLOBULIN; METABOLIC SYNDROME;
   CARDIOVASCULAR-DISEASE; PHYSICAL-ACTIVITY; VITAMIN-C; DURATION; MARKERS;
   APNEA; LIFE
AB Sleep is vital for cardiometabolic health, but a societal shift toward poor sleep is a prominent feature of many modern cultures. Concurrently, factors such as diet and lifestyle have also changed and may mediate the relationship between sleep quality and cardiometabolic health. Objectives were to explore (1) the interrelationship and (2) mediating effect of inflammation, oxidative stress, and antioxidants on sleep quality and cardiometabolic health. Cross-sectional data from the US National Health and Nutritional Examination Survey 2005-06 (>= 20 y; N = 2,072) was used. Cardiometabolic health was defined as per the Joint Interim Statement; overall sleep quality was determined from six sleep habits and categorized as good, fair, poor, and very poor. Fair quality sleepers had optimal inflammation, oxidative stress, and antioxidant levels. Inflammation was above the current clinical reference range across all sleep quality categories, while oxidative stress was only within the clinical reference range for fair sleep quality. Selected sleep quality-cardiometabolic health relationships were mediated by inflammation, oxidative stress, and antioxidants and were moderated by sex. Our results provide initial evidence of a potential role for inflammation, oxidative stress, and antioxidants in the pathway between poor sleep quality-cardiometabolic decline. Further prospective research is needed to confirm our results.
C1 [Kanagasabai, Thirumagal; Ardern, Chris I.] York Univ, Sch Kinesiol & Hlth Sci, Toronto, ON M3J 1P3, Canada.
C3 York University - Canada
RP Ardern, CI (corresponding author), York Univ, Sch Kinesiol & Hlth Sci, Toronto, ON M3J 1P3, Canada.
EM cardern@yorku.ca
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NR 51
TC 32
Z9 33
U1 1
U2 9
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 0962-9351
EI 1466-1861
J9 MEDIAT INFLAMM
JI Mediat. Inflamm.
PY 2015
VL 2015
AR 824589
DI 10.1155/2015/824589
PG 11
WC Cell Biology; Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Immunology
GA CV1VR
UT WOS:000364046700001
PM 26568665
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Stoica, F
   Aprodu, I
   Enachi, E
   Stanciuc, N
   Condurache, NN
   Duta, DE
   Bahrim, GE
   Rapeanu, G
AF Stoica, Florina
   Aprodu, Iuliana
   Enachi, Elena
   Stanciuc, Nicoleta
   Condurache, Nina Nicoleta
   Duta, Denisa Eglantina
   Bahrim, Gabriela Elena
   Rapeanu, Gabriela
TI Bioactive's Characterization, Biological Activities, and In Silico
   Studies of Red Onion (Allium cepa L.) Skin Extracts
SO PLANTS-BASEL
LA English
DT Article
DE red onion skins; anthocyanins; antioxidant activity; thermal stability;
   molecular modeling; biological activity
ID THERMAL-DEGRADATION KINETICS; ANTIOXIDANT ACTIVITIES; METABOLIC
   SYNDROME; PHENOLIC-COMPOUNDS; PANCREATIC LIPASE; ANTHOCYANINS; JUICE;
   CONSTITUENTS; POLYPHENOLS; QUERCETIN
AB This study aimed to investigate the thermal stability and biological activities of the phytochemicals from the red onion skins extract, which are a rich source of anthocyanins. Eight anthocyanins were identified in the extract by high-performance liquid chromatography, the most abundant ones being cyanidin 3-O-laminaribioside and cyanidin 3-O-(6 & DPRIME;-malonoyl-laminaribioside). The study also involved the assessment of the thermal degradation kinetics of anthocyanins and antioxidant activity in the 75-155 & DEG;C temperature range. The thermal degradation kinetics was described using the first-order kinetics model. In terms of thermal stability, increasing the temperature resulted in lower half-life values (t(1/2)) and higher degradation rate constant values (k) for both anthocyanins and antioxidant activity. The thermodynamic parameters revealed that the phytochemicals' degradation is a non-spontaneous and endothermic reaction. Furthermore, the inhibitory effect of the extract was investigated against the enzymes affiliated with metabolic syndrome, oxidative stress, and inflammatory process diseases. Thus, we also demonstrated that the red onion skins extract exerted inhibitory activity on alpha-glucosidase, alpha-amylase, lipase, and lipoxygenase. Considering the high content of bioactives and various biological properties, the red onion skins extract is suitable for multiple applications.
C1 [Stoica, Florina; Aprodu, Iuliana; Enachi, Elena; Stanciuc, Nicoleta; Condurache, Nina Nicoleta; Bahrim, Gabriela Elena; Rapeanu, Gabriela] Dunarea de Jos Univ Galati, Fac Food Sci & Engn, 111 Domneasca St, Galati 800201, Romania.
   [Duta, Denisa Eglantina] Natl Inst Res & Dev Food Bioresources IBA Buchare, 6 Dinu Vintila St, Bucharest 021102, Romania.
C3 Dunarea De Jos University Galati; National Research & Development
   Institute for Food Bioresources - IBA Bucharest
RP Rapeanu, G (corresponding author), Dunarea de Jos Univ Galati, Fac Food Sci & Engn, 111 Domneasca St, Galati 800201, Romania.
EM florina.stoica@ugal.ro; iuliana.aprodu@ugal.ro; elena.ionita@ugal.ro;
   nicoleta.stanciuc@ugal.ro; nina.condurache@ugal.ro;
   denisa.duta@bioresurse.ro; gabriela.bahrim@ugal.ro;
   gabriela.rapeanu@ugal.ro
RI Enachi, Elena/S-9025-2016; Stoica, Florina/KQU-0675-2024; Aprodu,
   Iuliana/B-3535-2011; Lazăr, Nina/AEA-6211-2022; Bahrim,
   Gabriela-Elena/G-4935-2013; DUTA, Denisa/C-7057-2017
OI stoica, florina/0000-0002-3841-3068; Enachi, Elena/0000-0002-4014-213X;
   Bahrim, Gabriela-Elena/0000-0001-8210-1793; DUTA,
   Denisa/0000-0002-8821-7268; Lazar (Condurache),
   Nina-Nicoleta/0000-0002-7182-8820; Rapeanu, Gabriela/0000-0002-5804-2786
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NR 66
TC 9
Z9 9
U1 1
U2 13
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
SN 2223-7747
J9 PLANTS-BASEL
JI Plants-Basel
PD NOV
PY 2021
VL 10
IS 11
AR 2330
DI 10.3390/plants10112330
PG 17
WC Plant Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences
GA XJ6GP
UT WOS:000726884200001
PM 34834693
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Dineen, SL
   McKenney, ML
   Bell, LN
   Fullenkamp, AM
   Schultz, KA
   Alloosh, M
   Chalasani, N
   Sturek, M
AF Dineen, Stacey L.
   McKenney, Mikaela L.
   Bell, Lauren N.
   Fullenkamp, Allison M.
   Schultz, Kyle A.
   Alloosh, Mouhamad
   Chalasani, Naga
   Sturek, Michael
TI Metabolic Syndrome Abolishes Glucagon-Like Peptide 1 Receptor Agonist
   Stimulation of SERCA in Coronary Smooth Muscle
SO DIABETES
LA English
DT Article
ID ER STRESS; APOPTOSIS; PROLIFERATION; EXENDIN-4
AB Metabolic syndrome (MetS) doubles the risk of adverse cardiovascular events. Glucagon-like peptide 1 (GLP-1) receptor agonists induce weight loss, increase insulin secretion, and improve glucose tolerance. Studies in healthy animals suggest cardioprotective properties of GLP-1 receptor agonists, perhaps partially mediated by improved sarco-endoplasmic reticulum Ca2+ ATPase (SERCA) activity. We examined the acute effect of GLP-1 receptor agonists on coronary smooth muscle cells (CSM) enzymatically isolated from lean, healthy Ossabaw miniature swine. Intracellular Ca2+ handling was interrogated with fura-2. The GLP-1 receptor agonist exenatide activated SERCA but did not alter other Ca2+ transporters. Further, we tested the hypothesis that chronic, in vivo treatment with GLP-1 receptor agonist AC3174 would attenuate coronary artery disease (CAD) in swine with MetS. MetS was induced in 20 swine by 6 months' feeding of a hypercaloric, atherogenic diet. Swine were then randomized (n = 10/group) into placebo or AC3174 treatment groups and continued the diet for an additional 6 months. AC3174 treatment attenuated weight gain, increased insulin secretion, and improved glucose tolerance. Intravascular ultrasound and histology showed no effect of AC3174 on CAD. MetS abolished SERCA activation by GLP-1 receptor agonists. We conclude that MetS confers vascular resistance to GLP-1 receptor agonists, partially through impaired cellular signaling steps involving SERCA.
C1 [Dineen, Stacey L.; McKenney, Mikaela L.; Schultz, Kyle A.; Alloosh, Mouhamad; Chalasani, Naga; Sturek, Michael] Indiana Univ Sch Med, Dept Cellular & Integrat Physiol, Indianapolis, IN 46202 USA.
   [Bell, Lauren N.; Fullenkamp, Allison M.; Chalasani, Naga] Indiana Univ Sch Med, Dept Med, Indianapolis, IN 46202 USA.
C3 Indiana University System; Indiana University Bloomington; Indiana
   University System; Indiana University Bloomington
RP Sturek, M (corresponding author), Indiana Univ Sch Med, Dept Cellular & Integrat Physiol, Indianapolis, IN 46202 USA.
EM msturek@iu.edu
RI Sturek, Michael/CAH-2948-2022
OI Sturek, Michael/0000-0002-2920-7406
FU National Institutes of Health [HL-062552]
FX This study was supported by National Institutes of Health grant
   HL-062552.
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NR 25
TC 15
Z9 21
U1 0
U2 7
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0012-1797
EI 1939-327X
J9 DIABETES
JI Diabetes
PD SEP
PY 2015
VL 64
IS 9
BP 3321
EP 3327
DI 10.2337/db14-1790
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA CP9AE
UT WOS:000360185300031
PM 25845661
OA Green Accepted, Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Nam, WS
   Park, KM
   Park, JW
AF Nam, Woo Suk
   Park, Kwon Moo
   Park, Jeen-Woo
TI RNA interference targeting cytosolic NADP<SUP>+</SUP>-dependent
   isocitrate dehydrogenase exerts anti-obesity effect in vitro and in vivo
SO BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
LA English
DT Article
DE NADPH; Obesity; RNAi; Adipogenesis; Lipogenesis
ID OXIDATIVE STRESS; NAD(P)H OXIDASE; METABOLIC SYNDROME; REACTIVE OXYGEN;
   NITRIC-OXIDE; GLUCOSE-6-PHOSPHATE-DEHYDROGENASE; OBESITY; EXPRESSION;
   ENZYMES; DAMAGE
AB A metabolic abnormality in lipid biosynthesis is frequently associated with obesity and hyperlipidemia. Nicotinamide adenine dinucleotide phosphate-oxidase (NADPH) is an essential reducing equivalent for numerous enzymes required in fat and cholesterol biosynthesis. Cytosolic NADP(+)-dependent isocitrate dehydrogenase (IDPc) has been proposed as a key enzyme for supplying cytosolic NADPH. We report here that knockdown of IDPc expression by Ribonucleic acid (RNA) interference (RNAi) inhibited adipocyte differentiation and lipogenesis in 3T3-L1 preadipocytes and mice. Attenuated IDPc expression by IDPc small interfering RNA (siRNA) resulted in a reduction of differentiation and triglyceride level and adipogenic protein expression as well as suppression of glucose uptake in cultured adipocytes. In addition, the attenuation of Nox activity and Reactive oxygen species (ROS) generation accompanied with knockdown of IDPc was associated with inhibition of adipogenesis and lipogenesis. The loss of body weight and the reduction of triglyceride level were also observed in diet-induced obese mice transduced with IDPc short-hairpin (shRNA). Taken together, the inhibiting effect of RNAi targeting IDPc on adipogenesis and lipid biosynthesis is considered to be of therapeutic value in the treatment and prevention of obesity and obesity-associated metabolic syndrome. (C) 2012 Elsevier B.V. All rights reserved.
C1 [Nam, Woo Suk; Park, Jeen-Woo] Kyungpook Natl Univ, Coll Nat Sci, Sch Life Sci & Biotechnol, Taegu 702701, South Korea.
   [Park, Kwon Moo] Kyungpook Natl Univ, Dept Anat, Sch Med, Taegu 700422, South Korea.
C3 Kyungpook National University (KNU); Kyungpook National University (KNU)
RP Park, JW (corresponding author), Kyungpook Natl Univ, Coll Nat Sci, Sch Life Sci & Biotechnol, Taegu 702701, South Korea.
EM parkjw@knu.ac.kr
RI park, jun yeon/GPX-5293-2022
FU Ministry of Health, Welfare & Family Affairs, Republic of Korea
   [A084042]; National Research Foundation of Korea (NRF); Korean
   government (MEST) [2011-0001256, 2011-0025802]
FX This work was supported by a grant from the Korea Healthcare Technology
   R&D Project Ministry of Health, Welfare & Family Affairs, Republic of
   Korea (A084042) and the National Research Foundation of Korea (NRF)
   grants funded by the Korean government (MEST) (2011-0001256 and
   2011-0025802). We thank Eun Kyeong Shin for technical assistance.
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NR 36
TC 19
Z9 20
U1 0
U2 6
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0925-4439
J9 BBA-MOL BASIS DIS
JI Biochim. Biophys. Acta-Mol. Basis Dis.
PD AUG
PY 2012
VL 1822
IS 8
BP 1181
EP 1188
DI 10.1016/j.bbadis.2012.04.003
PG 8
WC Biochemistry & Molecular Biology; Biophysics; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Cell Biology
GA 969CH
UT WOS:000306032800001
PM 22542506
OA Bronze
DA 2025-06-11
ER

PT J
AU Silaghi, AC
   Pais, R
   Valea, A
   Mironiuc, AI
   Silaghi, H
AF Silaghi, Alina Cristina
   Pais, Raluca
   Valea, Ana
   Mironiuc, Aurel Ion
   Silaghi, Horatiu
TI Epicardial adipose tissue and relationship with coronary artery disease
SO CENTRAL EUROPEAN JOURNAL OF MEDICINE
LA English
DT Review
DE Epicardial adipose tissue; Visceral adiposity; Cytokines; Coronary
   artery disease
ID LEFT-VENTRICULAR STRUCTURE; INTIMA-MEDIA THICKNESS; ACUTE
   MYOCARDIAL-INFARCTION; BODY-FAT DISTRIBUTION; PIGS IN-VIVO; METABOLIC
   SYNDROME; UNCOMPLICATED OBESITY; INSULIN-RESISTANCE; OXIDATIVE STRESS;
   DIASTOLIC DYSFUNCTION
AB Epicardial adipose tissue (EAT) is metabolically active tissue that accumulates around the coronary arteries. Epicardial fat is a rich source of free fatty acids and may contribute to local inflammatory load by increased synthesis of inflammatory cytokines. Direct passage of bioactive molecules into the coronary arteries due to close contact with the vascular wall and the lack of fascia may contribute to the pathogenesis of coronary artery disease. Direct correlation between visceral fat and EAT defines the latter as an indirect marker of intra-abdominal visceral adiposity. EAT is related to anthropometric and clinical features of the metabolic syndrome (MS) and to hepatic transaminases as markers of steatohepatitis. An increase in EAT thickness is related to an increase in left ventricular mass and is correlated with atrial enlargement and impairment in diastolic filling in obesity. Echocardiographic study of EAT is an easy and reliable imaging indicator of visceral adiposity and cardiovascular risk. EAT is an independent factor strongly correlated with significant coronary stenosis. A level of EAT above an established average value can be considered a predictive marker of cardiovascular risk. We review the most recent studies proving the specific active role of EAT in the development of cardiac disease.
C1 [Silaghi, Alina Cristina; Valea, Ana] Cty Clin Emergency Hosp, Dept Endocrinol, Cluj Napoca 400349, Romania.
   [Pais, Raluca] Univ Med & Pharm Iuliu Hatieganu, Dept Internal Med 2, Cluj Napoca 400006, Romania.
   [Mironiuc, Aurel Ion; Silaghi, Horatiu] Univ Med & Pharm Iuliu Hatieganu, Dept Surg 2, Cluj Napoca 400006, Romania.
C3 Iuliu Hatieganu University of Medicine & Pharmacy; Iuliu Hatieganu
   University of Medicine & Pharmacy
RP Silaghi, AC (corresponding author), Cty Clin Emergency Hosp, Dept Endocrinol, Cluj Napoca 400349, Romania.
EM alinasilaghi@yahoo.com
RI valea, ana/GRJ-8005-2022; Silaghi, Cristina Alina/KPB-7315-2024;
   Silaghi, Horatiu/LYP-2128-2024
OI Silaghi, Cristina Alina/0000-0002-8233-6960; Silaghi,
   Horatiu/0000-0001-9060-610X
FU CNCSIS-UEFISCSU, Romania [682/2010]
FX This work was supported by a scientific grant from the CNCSIS-UEFISCSU,
   Romania, PN II-RU project number 682/2010.
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NR 79
TC 4
Z9 5
U1 0
U2 17
PU VERSITA
PI WARSAW
PA SOLIPSKA 14A-1, 02-482 WARSAW, POLAND
SN 1895-1058
J9 CENT EUR J MED
JI Cent. Eur. J. Med.
PD JUN
PY 2011
VL 6
IS 3
BP 251
EP 262
DI 10.2478/s11536-011-0011-7
PG 12
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 747CN
UT WOS:000289298000001
OA hybrid
DA 2025-06-11
ER

PT J
AU Bo, S
   Pisu, E
AF Bo, Simona
   Pisu, Elisabetta
TI Role of dietary magnesium in cardiovascular disease prevention, insulin
   sensitivity and diabetes
SO CURRENT OPINION IN LIPIDOLOGY
LA English
DT Review
DE cardiovascular diseases; diabetes; inflammation; insulin resistance;
   magnesium
ID CORONARY-HEART-DISEASE; C-REACTIVE PROTEIN; OLDER US WOMEN; METABOLIC
   SYNDROME; ENDOTHELIAL-CELLS; ARTERY-DISEASE; DRINKING-WATER; OBESE
   SUBJECTS; RISK; HYPERTENSION
AB Purpose of review
   This review summarizes the evidence for benefits of magnesium on metabolic abnormalities, inflammatory parameters, and cardiovascular risk factors and related-potential mechanisms. Controversy due to contrasting results in the literature is also discussed.
   Recent findings
   Increased dietary magnesium intake confers protection against the incidence of diabetes, metabolic syndrome, hypertension, and cardiovascular disease. It ameliorates insulin resistance, serum lipid profiles, and lowers inflammation, endothelial dysfunction, oxidative stress, and platelet aggregability. Magnesium acts as a mild calcium antagonist on vascular smooth muscle tone, and on postreceptor insulin signaling; it is critically involved in energy metabolism, fatty acid synthesis, glucose utilization, ATPase functions, release of neurotransmitters, and endothelial cell function and secretion. Prospective studies, however, have found only a modest effect for dietary magnesium on incident pathologies. Furthermore, magnesium supplementation on glucose metabolism, blood lipid levels, and ischemic heart disease has given inconsistent results.
   Summary
   There is strong biological plausibility for the direct impact of magnesium intake on metabolic and cardiovascular risk factors, but in-vivo magnesium deficiency might play only a modest role. Reverse causality, the strong association between magnesium and other beneficial nutrients, or the possibility that people who choose magnesium-rich foods are more health-conscious may be confounding factors.
C1 [Bo, Simona; Pisu, Elisabetta] Univ Turin, Dept Internal Med, I-10126 Turin, Italy.
C3 University of Turin
RP Bo, S (corresponding author), Univ Turin, Dept Internal Med, Corso Dogliotti 14, I-10126 Turin, Italy.
EM sbo@molinette.piemonte.it
RI Bo, Simona/AAC-1110-2019
OI Bo, Simona/0000-0001-6862-8628
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NR 60
TC 151
Z9 162
U1 0
U2 29
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0957-9672
EI 1473-6535
J9 CURR OPIN LIPIDOL
JI Curr. Opin. Lipidology
PD FEB
PY 2008
VL 19
IS 1
BP 50
EP 56
DI 10.1097/MOL.0b013e3282f33ccc
PG 7
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism; Peripheral
   Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism;
   Cardiovascular System & Cardiology
GA 260QA
UT WOS:000253023800010
PM 18196987
DA 2025-06-11
ER

PT J
AU Park, S
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AF Park, Sangshin
   Choi, Nam-Kyong
   Kim, Seungsoo
   Lee, Chang-Hoon
TI The relationship between metabolic syndrome and asthma in the elderly
SO SCIENTIFIC REPORTS
LA English
DT Article
ID BODY-MASS INDEX; INSULIN-RESISTANCE; OXIDATIVE STRESS; LUNG-FUNCTION;
   OBESITY; ASSOCIATION; PREDICTOR; DISEASE; ADULTS; YOUNG
AB The burden of asthma in the elderly is increasing, but the etiology of asthma in the elderly is not clearly understood. Recent studies have reported the epidemiological link between metabolic syndrome (MS) and asthma, but it has rarely been studied in the elderly. This study investigated the association between MS and asthma and the contribution of insulin resistance (IR) and systemic inflammation to this MS-asthma association in the elderly. Our study analyzed 4,060 elderly participants (>= 65 years old) from a cross-sectional survey, the Korean National Health and Nutritional Examination Survey 2007-2012. Mediation analyses were performed to examine whether IR and systemic inflammation mediates the MS-asthma association. Participants with MS had significantly higher prevalence of asthma (adjusted odds ratio = 1.34; 95% confidence interval = 1.09-1.64), and those who had greater waist circumference and lower HDL-C were especially likely to have asthma. Participants with IR and systemic inflammation were associated with higher prevalence of asthma. Prevalence of IR and systemic inflammation were higher in participants with MS or with each MS component. The MS-asthma association was substantially mediated by IR and systemic inflammation. Our study showed a significant association between MS and asthma in the elderly. MS might affect asthma through both IR and systemic inflammation.
C1 [Park, Sangshin] Brown Univ, Rhode Isl Hosp, Warren Alpert Med Sch, Ctr Int Hlth Res, Providence, RI 02903 USA.
   [Park, Sangshin] Brown Univ, Dept Pediat, Warren Alpert Med Sch, Providence, RI 02912 USA.
   [Choi, Nam-Kyong] Ewha Womans Univ, Dept Hlth Convergence, Seoul, South Korea.
   [Kim, Seungsoo] Catholic Univ Korea Daejeon, St Marys Hosp, Dept Internal Med, Div Allergy & Pulmonol, Daejeon, South Korea.
   [Lee, Chang-Hoon] Seoul Natl Univ Hosp, Dept Internal Med, Div Pulm & Crit Care Med, Seoul, South Korea.
C3 Lifespan Health Rhode Island; Rhode Island Hospital; Brown University;
   Brown University; Ewha Womans University; Seoul National University
   (SNU); Seoul National University Hospital
RP Lee, CH (corresponding author), Seoul Natl Univ Hosp, Dept Internal Med, Div Pulm & Crit Care Med, Seoul, South Korea.
EM kauri670@empal.com
RI Lee, Chang-Hoon/AAC-7650-2021; Park, Sangshin/K-6889-2014
OI Park, Sangshin/0000-0003-2407-0962
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NR 38
TC 26
Z9 26
U1 3
U2 10
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD JUN 20
PY 2018
VL 8
AR 9378
DI 10.1038/s41598-018-26621-z
PG 8
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA GJ8HM
UT WOS:000435630000004
PM 29925841
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Taylor, JK
   Plaisance, EP
   Mahurin, AJ
   Mestek, ML
   Moncada-Jimenez, J
   Grandjean, PW
AF Taylor, James Kyle
   Plaisance, Eric P.
   Mahurin, A. Jack
   Mestek, Michael L.
   Moncada-Jimenez, Jose
   Grandjean, Peter W.
TI Paraoxonase responses to exercise and niacin therapy in men with
   metabolic syndrome
SO REDOX REPORT
LA English
DT Article
DE Paraoxonase; Lipoprotein particle size; Lipid oxidation; Exercise;
   Niacin
ID EXTENDED-RELEASE NIACIN; LOW-DENSITY-LIPOPROTEIN; OXIDATIVE STRESS;
   AEROBIC EXERCISE; ANTIOXIDANT; CHOLESTEROL; EFFICACY; SAFETY; CORONARY;
   NIASPAN
AB Our purpose was to characterize changes in paraoxonase 1 (PON1) activity and concentration after single aerobic exercise sessions conducted before and after 6 weeks of niacin therapy in men with metabolic syndrome (MetS). Twelve men with MetS expended 500 kcal by walking at 65% of VO2max before and after a 6-week regimen of niacin. Niacin doses were titrated by 500 mg/week from 500 to 1500 mg/day and maintained at 1500 mg/day for the last 4 weeks. Fasting blood samples were collected before and 24 hours after each exercise session and analyzed for PON1 activity, PON1 concentration, myeloperoxidase (MPO), apolipoprotein A1, oxidized low-density lipoprotein (oLDL), lipoprotein particle sizes and concentrations. PON1 activity, PON1 concentration, MPO, and oLDL were unaltered following the independent effects of exercise and niacin (P > 0.05 for all). High-density lipoprotein particle size decreased by 3% (P = 0.040) and concentrations of small very low-density lipoprotein increased (P = 0.016) following exercise. PON1 activity increased 6.1% (P = 0.037) and PON1 concentrations increased 11.3% (P = 0.015) with the combination of exercise and niacin. Exercise and niacin works synergistically to increase PON1 activity and concentration with little or no changes in lipoproteins or markers of lipid oxidation.
C1 [Taylor, James Kyle] Auburn Univ, Div Clin Lab Sci, Montgomery, AL 36117 USA.
   [Plaisance, Eric P.] Univ Alabama Birmingham, Dept Human Studies, Birmingham, AL USA.
   [Mahurin, A. Jack] Baptist Family Med Residency Program, Montgomery, AL USA.
   [Mestek, Michael L.] Covidien Resp Monitoring Solut, Boulder, CO USA.
   [Moncada-Jimenez, Jose] Univ Costa Rica, Sch Phys Educ & Sports, San Jose, Costa Rica.
   [Grandjean, Peter W.] Baylor Univ, Ctr Hlth Living, Waco, TX 76798 USA.
   [Grandjean, Peter W.] Baylor Univ, Baylor Labs Exercise Sci & Technol HHPR, Waco, TX 76798 USA.
C3 Auburn University System; Auburn University; Auburn University
   Montgomery; University of Alabama System; University of Alabama
   Birmingham; Covidien; Universidad Costa Rica; Baylor University; Baylor
   University
RP Taylor, JK (corresponding author), Auburn Univ, Montgomery, AL 36117 USA.
EM jtaylor@aum.edu
RI Moncada-Jimenez, Jose/A-8423-2013
OI Moncada-Jimenez, Jose/0000-0001-9807-5163; Taylor, James
   Kyle/0000-0001-6688-1718
FU Global Pharmaceuticals Research Development; Abbott Laboratories
FX Supported by a Global Pharmaceuticals Research & Development Grant from
   Abbott Laboratories.
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NR 38
TC 11
Z9 11
U1 1
U2 7
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1351-0002
EI 1743-2928
J9 REDOX REP
JI Redox Rep.
PD JAN
PY 2015
VL 20
IS 1
DI 10.1179/1351000214Y.0000000103
PG 7
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA AW8WE
UT WOS:000346538600006
PM 25180827
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Kim, J
   Kim, SH
   Kang, H
   Lee, S
   Park, SY
   Cho, Y
   Lim, YM
   Ahn, JW
   Kim, YH
   Chung, S
   Choi, CS
   Jang, YJ
   Park, HS
   Heo, Y
   Kim, KH
   Lee, MS
AF Kim, Jinyoung
   Kim, Seong Hun
   Kang, Hyereen
   Lee, Soyeon
   Park, Shi-Young
   Cho, Yoonil
   Lim, Yu-Mi
   Ahn, Ji Woong
   Kim, Young-Hwan
   Chung, Seungsoo
   Choi, Cheol Soo
   Jang, Yeon Jin
   Park, Hye Soon
   Heo, Yoonseok
   Kim, Kook Hwan
   Lee, Myung-Shik
TI TFEB-GDF15 axis protects against obesity and insulin resistance as a
   lysosomal stress response
SO NATURE METABOLISM
LA English
DT Article
ID DIFFERENTIATION FACTOR 15; SUBCUTANEOUS ADIPOSE-TISSUE;
   LIPID-METABOLISM; AUTOPHAGY DEFICIENCY; T-CELLS; TFEB; THERMOGENESIS;
   TRANSCRIPTION; INFLAMMASOME; CALCINEURIN
AB Kim et al. reveal that TFEB expression is protective in the setting of diet-induced obesity by activating the expression of GDF15 in adipose tissue macrophages in mice and humans.
   TFEB, a key regulator of lysosomal biogenesis and autophagy, is induced not only by nutritional deficiency but also by organelle stress. Here, we find that Tfeb and its downstream genes are upregulated together with lipofuscin accumulation in adipose tissue macrophages (ATMs) of obese mice or humans, suggestive of obesity-associated lysosomal dysfunction/stress in ATMs. Macrophage-specific TFEB-overexpressing mice display complete abrogation of diet-induced obesity, adipose tissue inflammation and insulin resistance, which is independent of autophagy, but dependent on TFEB-induced GDF15 expression. Palmitic acid induces Gdf15 expression through lysosomal Ca2+-mediated TFEB nuclear translocation in response to lysosomal stress. In contrast, mice fed a high-fat diet with macrophage-specific Tfeb deletion show aggravated adipose tissue inflammation and insulin resistance, accompanied by reduced GDF15 level. Finally, we observe activation of TFEB-GDF15 in ATMs of obese humans as a consequence of lysosomal stress. These findings highlight the importance of the TFEB-GDF15 axis as a lysosomal stress response in obesity or metabolic syndrome and as a promising therapeutic target for treatment of these conditions.
C1 [Kim, Jinyoung; Kim, Seong Hun; Kang, Hyereen; Lee, Soyeon; Lim, Yu-Mi; Kim, Kook Hwan; Lee, Myung-Shik] Yonsei Univ, Severance Biomed Sci Inst, Coll Med, Seoul, South Korea.
   [Kim, Seong Hun; Kim, Kook Hwan] GI Innovat, Discovery 1 Team, Seoul, South Korea.
   [Park, Shi-Young; Cho, Yoonil] Gachon Univ, Lee Gil Ya Canc & Diabet Inst, Korea Mouse Metab Phenotyping Ctr, Coll Med, Incheon, South Korea.
   [Ahn, Ji Woong; Kim, Young-Hwan; Chung, Seungsoo] Yonsei Univ, Dept Physiol, Brain Korea 21 Project Med Sci, Coll Med, Seoul, South Korea.
   [Choi, Cheol Soo] Gachon Univ, Endocrinol, Internal Med, Gil Med Ctr, Incheon, South Korea.
   [Jang, Yeon Jin] Univ Ulsan, Dept Physiol, Coll Med, Seoul, South Korea.
   [Park, Hye Soon] Univ Ulsan, Dept Family Med, Coll Med, Seoul, South Korea.
   [Heo, Yoonseok] Inha Univ, Dept Gen Surg, Coll Med, Incheon, South Korea.
   [Lee, Myung-Shik] Yonsei Univ, Dept Internal Med, Coll Med, Seoul, South Korea.
C3 Yonsei University; Yonsei University Health System; Gachon University;
   Yonsei University; Yonsei University Health System; Gachon University;
   University of Ulsan; University of Ulsan; Inha University; Yonsei
   University; Yonsei University Health System
RP Kim, KH; Lee, MS (corresponding author), Yonsei Univ, Severance Biomed Sci Inst, Coll Med, Seoul, South Korea.; Kim, KH (corresponding author), GI Innovat, Discovery 1 Team, Seoul, South Korea.; Lee, MS (corresponding author), Yonsei Univ, Dept Internal Med, Coll Med, Seoul, South Korea.
EM khkim1978@gi-innovation.com; mslee0923@yuhs.ac
RI Lee, Myung/C-9606-2011; JINYOUNG, KIM/IAM-3353-2023
OI Lee, Myung-Shik/0000-0003-3292-1720; Chung,
   Seungsoo/0000-0002-3119-9628; Kim, Jinyoung/0000-0002-3810-8549; Kim,
   Kook Hwan/0000-0003-2702-9156; Ahn, Ji Woong/0000-0001-6951-5422
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NR 67
TC 57
Z9 62
U1 2
U2 29
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
EI 2522-5812
J9 NAT METAB
JI Nat. Metab.
PD MAR
PY 2021
VL 3
IS 3
BP 410
EP U215
DI 10.1038/s42255-021-00368-w
PG 34
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA RF4DX
UT WOS:000634791100014
PM 33758420
DA 2025-06-11
ER

PT J
AU Vermeltfoort, IAC
   Bondarenko, O
   Raijmakers, PGHM
   Odekerken, DAM
   Kuijper, AFM
   Zwijnenburg, A
   van der Vis-Melsen, MJE
   Twisk, JWR
   Beek, AM
   Teule, GJJ
   van Rossum, AC
AF Vermeltfoort, Ilse A. C.
   Bondarenko, Olga
   Raijmakers, Pieter G. H. M.
   Odekerken, Diego A. M.
   Kuijper, Aaf F. M.
   Zwijnenburg, Anton
   van der Vis-Melsen, Mary J. E.
   Twisk, Jos W. R.
   Beek, Aernout M.
   Teule, Gerrit J. J.
   van Rossum, Albert C.
TI Is subendocardial ischaemia present in patients with chest pain and
   normal coronary angiograms? A cardiovascular MR study
SO EUROPEAN HEART JOURNAL
LA English
DT Article
DE angina pectoris with normal; coronary arteries; cardiac syndrome X;
   cardiovascular MR; microvascular angina
ID CARDIAC SYNDROME-X; MYOCARDIAL-PERFUSION; ANGINA-PECTORIS; STRESS;
   RESPONSES; RESERVE; ARTERIOGRAMS; DYSFUNCTION; PERCEPTION; ARTERIES
AB Aims On the basis of an MRI study it has been suggested that subendocardial hypoperfusion is present in patients with cardiac syndrome X. However, further work is required to test whether these findings can be generalized.
   Methods and results MRI was used to visually and semi-quantitatively assess subendocardial and subepicardial perfusion, at rest and during an infusion of adenosine, in 20 patients with angina pectoris and normal coronary angiograms. A myocardial perfusion index (MPI) was calculated using the normalized upstope of myocardial signal enhancement. An index for myocardial perfusion reserve (MPRI) was calculated by dividing the MPI values at maximal vasodilatation by the values at rest. The MPI in our study population increased significantly during adenosine infusion in both the subendocardium (from 0.091 +/- 0.020 to 0.143 +/- 0.030; P < 0.001) and the subepicardium (from 0.074 +/- 0.017 to 0.135 +/- 0.03; P < 0.001). The overall MPRI was 1.83 +/- 0.50.
   Conclusion The results show that patients with chest pain and normal coronary angiograms had significant perfusion responses to adenosine in both the subendocardium and subepicardium. In the present study we found no evidence for subendocardial hypoperfusion in these patients.
C1 Vrije Univ Amsterdam, Med Ctr, Dept Nucl Med & PET Res, NL-1007 MB Amsterdam, Netherlands.
   Vrije Univ Amsterdam, Med Ctr, Dept Cardiol, Amsterdam, Netherlands.
   Vrije Univ Amsterdam, Med Ctr, Dept Clin Epidemiol & Biostat, Amsterdam, Netherlands.
   Spaarne Hosp, Dept Cardiol, Hoofdorf, Netherlands.
   Spaarne Hosp, Dept Nucl Med, Hoofdorf, Netherlands.
C3 Vrije Universiteit Amsterdam; Vrije Universiteit Amsterdam; Vrije
   Universiteit Amsterdam; Spaarne Hospital; Spaarne Hospital
RP Vermeltfoort, IAC (corresponding author), Vrije Univ Amsterdam, Med Ctr, Dept Nucl Med & PET Res, NL-1007 MB Amsterdam, Netherlands.
EM i.vermeltfoort@vumc.nl
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U1 0
U2 1
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0195-668X
EI 1522-9645
J9 EUR HEART J
JI Eur. Heart J.
PD JUL
PY 2007
VL 28
IS 13
BP 1554
EP 1558
DI 10.1093/eurheartj/ehm088
PG 5
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 193JZ
UT WOS:000248271600006
PM 17504803
DA 2025-06-11
ER

PT J
AU Türkel, I
   Memi, G
   Yazgan, B
AF Turkel, Ibrahim
   Memi, Gulsun
   Yazgan, Burak
TI Impact of spexin on metabolic diseases and inflammation: An updated
   minireview
SO EXPERIMENTAL BIOLOGY AND MEDICINE
LA English
DT Review
DE Cardiovascular diseases; chronic kidney failure; diabetes; metabolic
   syndrome; inflammation; spexin
ID INSULIN-RESISTANCE; NEGATIVELY CORRELATE; IDENTIFICATION; EXPRESSION;
   GOLDFISH; HORMONES; GLUCOSE; OBESITY
AB Spexin (SPX) is a 14 amino acid length peptide hormone which was discovered using bioinformatic tools. It is extensively expressed in central and peripheral tissues and secreted into circulation in response to metabolic stress. Recent studies revealed that SPX acts as a multifunctional peptide in various metabolic processes such as body weight, food intake, energy balance, glucose and lipid metabolism, lipid storage, salt-water balance, and arterial blood pressure. Endogenous SPX is sensitive to metabolic changes, and circulating levels of SPX have been shown to be reduced in chronic diseases such as obesity, diabetes, and insulin resistance. Moreover, in fish and rodent models, systemic SPX treatment has positive effects on metabolism including reduced food intake, fat mass, lipid accumulation, and inflammation, improved insulin sensitivity, energy expenditure, and organ functions which are underlying mechanisms in diseases. Taken together, these findings suggest that SPX is a potential drug target for the development of new pharmacological strategies to cure metabolic diseases. This review focuses on metabolo-protective properties of SPX and discusses novel insights into the biology and mechanism of SPX in the pathogenesis of diabetes, obesity, non-alcoholic fatty liver disease, metabolic syndrome, polycystic ovary syndrome, cardiovascular diseases, and kidney diseases, which are considerable global health problems.
C1 [Turkel, Ibrahim] Hacettepe Univ, Fac Sport Sci, Div Exercise & Sport Physiol, TR-06800 Ankara, Turkey.
   [Memi, Gulsun] Adiyaman Univ, Fac Med, Dept Physiol, TR-02040 Adiyaman, Turkey.
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C3 Hacettepe University; Adiyaman University; Amasya University
RP Yazgan, B (corresponding author), Amasya Univ, Sabuncuoglu Serefeddin Hlth Serv Vocat Sch, Dept Med Serv & Tech, TR-05100 Amasya, Turkey.
EM burak_yazgan@yahoo.com
RI yazgan, burak/KIG-0400-2024
OI Memi, Gulsun/0000-0002-4897-6307; Turkel, Ibrahim/0000-0002-5187-8847;
   YAZGAN, BURAK/0000-0003-0717-7768
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NR 70
TC 17
Z9 17
U1 2
U2 27
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1535-3702
EI 1535-3699
J9 EXP BIOL MED
JI Exp. Biol. Med.
PD APR
PY 2022
VL 247
IS 7
BP 567
EP 573
AR 15353702211072443
DI 10.1177/15353702211072443
EA JAN 2022
PG 7
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 0N5YW
UT WOS:000748929900001
PM 35068225
OA Green Published
DA 2025-06-11
ER

PT J
AU Pawar, AS
   Zhu, XY
   Eirin, A
   Tang, H
   Jordan, KL
   Woollard, JR
   Lerman, A
   Lerman, LO
AF Pawar, Aditya S.
   Zhu, Xiang-Yang
   Eirin, Alfonso
   Tang, Hui
   Jordan, Kyra L.
   Woollard, John R.
   Lerman, Amir
   Lerman, Lilach O.
TI Adipose Tissue Remodeling in a Novel Domestic Porcine Model of
   Diet-Induced Obesity
SO OBESITY
LA English
DT Article
ID NECROSIS-FACTOR-ALPHA; CORONARY-ARTERY STENOSIS; OSSABAW MINIATURE
   SWINE; METABOLIC SYNDROME; EARLY ATHEROSCLEROSIS; INSULIN-RESISTANCE;
   OXIDATIVE STRESS; HYPERTENSION; DISEASE; MICE
AB ObjectiveTo establish and characterize a novel domestic porcine model of obesity.
   MethodsFourteen domestic pigs were fed normal (lean, n=7) or high-fat/high-fructose diet (obese, n=7) for 16 weeks. Subcutaneous abdominal adipose tissue biopsies were obtained after 8, 12, and 16 weeks of diet, and pericardial adipose tissue after 16 weeks, for assessments of adipocyte size, fibrosis, and inflammation. Adipose tissue volume and cardiac function were studied with multidetector computed tomography, and oxygenation was studied with magnetic resonance imaging. Plasma lipids profile, insulin resistance, and markers of inflammation were evaluated.
   ResultsCompared with lean pigs, obese pigs had elevated cholesterol and triglyceride levels, blood pressure, and insulin resistance. Both abdominal and pericardial fat volume increased in obese pigs after 16 weeks. In abdominal subcutaneous adipose tissue, adipocyte size and both tumor necrosis factor (TNF)- expression progressively increased. Macrophage infiltration showed in both abdominal and pericardial adipose tissues. Circulating TNF- increased in obese pigs only at 16 weeks. Compared with lean pigs, obese pigs had similar global cardiac function, but myocardial perfusion and oxygenation were significantly impaired.
   ConclusionsA high-fat/high-fructose diet induces in domestic pigs many characteristics of metabolic syndrome, which is useful for investigating the effects of the obesity.
C1 [Pawar, Aditya S.; Zhu, Xiang-Yang; Eirin, Alfonso; Tang, Hui; Jordan, Kyra L.; Woollard, John R.; Lerman, Lilach O.] Mayo Clin, Div Nephrol & Hypertens, Rochester, MN 55905 USA.
   [Lerman, Amir; Lerman, Lilach O.] Mayo Clin, Div Cardiovasc Dis, Rochester, MN USA.
C3 Mayo Clinic; Mayo Clinic
RP Lerman, LO (corresponding author), Mayo Clin, Div Nephrol & Hypertens, Rochester, MN 55905 USA.
EM lerman.lilach@mayo.edu
RI Lerman, Lilach/M-4962-2017; Pawar, Aditya/T-4504-2019; Tang,
   Hui/B-3643-2010; Eirin, Alfonso/N-9873-2013
OI Pawar, Aditya/0000-0002-9178-4386; Eirin, Alfonso/0000-0002-3864-9644
FU NIH [DK73608, HL121561, U01DK104273, C06-RR018898, UL1-TR000135]; Mayo
   Clinic Center for Regenerative Medicine
FX This study was partly supported by NIH grants DK73608, HL121561,
   U01DK104273, C06-RR018898, and UL1-TR000135 and the Mayo Clinic Center
   for Regenerative Medicine.
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NR 39
TC 69
Z9 69
U1 0
U2 19
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1930-7381
EI 1930-739X
J9 OBESITY
JI Obesity
PD FEB
PY 2015
VL 23
IS 2
BP 399
EP 407
DI 10.1002/oby.20971
PG 9
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA CA6QN
UT WOS:000349040400023
PM 25627626
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Seale, LA
   Hashimoto, AC
   Kurokawa, S
   Gilman, CL
   Seyedali, A
   Bellinger, FP
   Raman, AV
   Berry, MJ
AF Seale, Lucia A.
   Hashimoto, Ann C.
   Kurokawa, Suguru
   Gilman, Christy L.
   Seyedali, Ali
   Bellinger, Frederick P.
   Raman, Arjun V.
   Berry, Marla J.
TI Disruption of the Selenocysteine Lyase-Mediated Selenium Recycling
   Pathway Leads to Metabolic Syndrome in Mice
SO MOLECULAR AND CELLULAR BIOLOGY
LA English
DT Article
ID TYROSINE-PHOSPHATASE 1B; SELENOPROTEIN-P; PROSTATE-CANCER; VITAMIN-E;
   GLUTATHIONE-PEROXIDASE; INSULIN-RESISTANCE; ADIPOSE-TISSUE; BETA-CELLS;
   PROTEIN; EXPRESSION
AB Selenium (Se) is an essential trace element used for biosynthesis of selenoproteins and is acquired either through diet or cellular recycling mechanisms. Selenocysteine lyase (Scly) is the enzyme that supplies Se for selenoprotein biosynthesis via decomposition of the amino acid selenocysteine (Sec). Knockout (KO) of Scly in a mouse affected hepatic glucose and lipid homeostasis. Mice lacking Scly and raised on an Se-adequate diet exhibit hyperinsulinemia, hyperleptinemia, glucose intolerance, and hepatic steatosis, with increased hepatic oxidative stress, but maintain selenoprotein levels and circulating Se status. Insulin challenge of Scly KO mice results in attenuated Akt phosphorylation but does not decrease phosphorylation levels of AMP kinase alpha (AMPK alpha). Upon dietary Se restriction, Scly KO animals develop several characteristics of metabolic syndrome, such as obesity, fatty liver, and hypercholesterolemia, with aggravated hyperleptinemia, hyperinsulinemia, and glucose intolerance. Hepatic glutathione peroxidase I (GPx1) and selenoprotein S (SelS) production and circulating selenoprotein P (Sepp1) levels are significantly diminished. Scly disruption increases the levels of insulin-signaling inhibitor PTP1B. Our results suggest a dependence of glucose and lipid homeostasis on Scly activity. These findings connect Se and energy metabolism and demonstrate for the first time a unique physiological role of Scly in an animal model.
C1 [Seale, Lucia A.; Hashimoto, Ann C.; Kurokawa, Suguru; Gilman, Christy L.; Seyedali, Ali; Bellinger, Frederick P.; Raman, Arjun V.; Berry, Marla J.] Univ Hawaii Manoa, John A Burns Sch Med, Dept Cell & Mol Biol, Honolulu, HI 96822 USA.
C3 University of Hawaii System; University of Hawaii Manoa
RP Berry, MJ (corresponding author), Univ Hawaii Manoa, John A Burns Sch Med, Dept Cell & Mol Biol, Honolulu, HI 96822 USA.
EM mberry@hawaii.edu
RI Seale, Lucia/AFT-9036-2022
OI Seale, Lucia/0000-0002-0686-7516
FU National Institutes of Health [R01-DK47320, G12-MD007601, G12-RR003061]
FX This work was supported by National Institutes of Health grants
   R01-DK47320, G12-MD007601, and G12-RR003061.
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NR 66
TC 97
Z9 103
U1 0
U2 18
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0270-7306
EI 1098-5549
J9 MOL CELL BIOL
JI Mol. Cell. Biol.
PD OCT
PY 2012
VL 32
IS 20
BP 4141
EP 4154
DI 10.1128/MCB.00293-12
PG 14
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA 015JG
UT WOS:000309441600006
PM 22890841
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Visschers, RGJ
   Luyer, MD
   Schaap, FG
   Damink, SWMO
   Soeters, PB
AF Visschers, Ruben G. J.
   Luyer, Misha D.
   Schaap, Frank G.
   Damink, Steven W. M. Olde
   Soeters, Peter B.
TI The gut-liver axis
SO CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE
LA English
DT Review
DE autonomous neural system; bile salts; enterohepatic circulation; gut
   microbiota; metabolic syndrome
ID CHRONIC KIDNEY-DISEASE; PARENTERAL FISH-OIL; METABOLIC SYNDROME; CELL
   ACTIVATION; BILE-ACIDS; T-CELLS; NUTRITION; RECEPTOR; MICROBIOTA;
   FAILURE
AB Purpose of reviewThe liver adaptively responds to extra-intestinal and intestinal inflammation. In recent years, the role of the autonomic nervous system, intestinal failure and gut microbiota has been investigated in the development of hepatic, intestinal and extra-intestinal disease.Recent findingsThe autonomic nervous system can be stimulated via enteral fat leading to cholecystokinin release, stimulating receptors in the gut and in the brain. This promotes bowel integrity, dampening the inflammatory response to food antigens. Consensus exists that intravenously administered long-chain fatty acids can cause liver damage but randomized-controlled trials are lacking. Disruption of the enterohepatic circulation of bile salts can give rise to cholestasis and nonalcoholic fatty liver disease, which may progress to fibrosis and cirrhosis. Reduced intestinal availability of bile salts reduces stimulation of the farnesoid X receptor. This may induce hepatic bile salt overload and associated hepatotoxicity through reduced action of intestinal fibroblast growth factor 19. Evidence is put forward to suggest that the intestinal microbiota is associated with liver abnormalities.SummaryEnteral lipids reduce inflammation and liver damage during stress or systemic inflammation, whereas parenteral lipid is associated with liver damage. Maintaining the enterohepatic circulation of bile salts limits hepatic cholestasis through an farnesoid X receptor feedback pathway. Changes in gut microbiota composition may induce liver disease.
C1 [Visschers, Ruben G. J.] Orbis Med Ctr, Dept Surg, Sittard, Netherlands.
   [Luyer, Misha D.] Catharina Hosp, Dept Surg, Eindhoven, Netherlands.
   [Schaap, Frank G.; Damink, Steven W. M. Olde; Soeters, Peter B.] Maastricht Univ, Med Ctr, Dept Surg, NUTRIM Sch Nutr Toxicol & Metab, NL-6202 AZ Maastricht, Netherlands.
   [Damink, Steven W. M. Olde] Royal Free Hosp, London NW3 2QG, England.
   [Damink, Steven W. M. Olde] UCL, Div Surg & Intervent Sci, London, England.
C3 Orbis Medical Center; Catharina Hospital; Maastricht University;
   Maastricht University Medical Centre (MUMC); University of London;
   University College London; Royal Free London NHS Foundation Trust; UCL
   Medical School; University of London; University College London
RP Soeters, PB (corresponding author), Maastricht Univ, Med Ctr, Dept Surg, POB 5800, NL-6202 AZ Maastricht, Netherlands.
EM pb.soeters@maastrichtuniversity.nl
RI Olde Damink, Steven/U-7919-2019
OI Olde Damink, Steven/0000-0002-5202-9345; Schaap,
   Frank/0000-0002-1597-572X
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NR 58
TC 53
Z9 58
U1 0
U2 68
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1363-1950
EI 1473-6519
J9 CURR OPIN CLIN NUTR
JI Curr. Opin. Clin. Nutr. Metab. Care
PD SEP
PY 2013
VL 16
IS 5
BP 576
EP 581
DI 10.1097/MCO.0b013e32836410a4
PG 6
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 248UU
UT WOS:000326730700013
PM 23873346
DA 2025-06-11
ER

PT J
AU Remuzzi, A
   Remuzzi, G
AF Remuzzi, Andrea
   Remuzzi, Giuseppe
TI Potential protective effects of telmisartan on renal function
   deterioration
SO JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM
LA English
DT Review
DE angiotensin II peroxisome-activated receptor-gamma; angiotensin receptor
   antagonists; angiotensin-converting enzyme inhibitors; metabolic
   syndrome; insulin resistance renal diseases; renoprotection
ID AT(1) RECEPTOR ANTAGONIST; TYPE-2 DIABETES-MELLITUS; C-REACTIVE PROTEIN;
   BLOOD-PRESSURE; ENDOTHELIAL DYSFUNCTION; HYPERTENSIVE PATIENTS;
   OXIDATIVE STRESS; ACE-INHIBITION; ANGIOTENSIN; ADIPONECTIN
AB Experimental and clinical evidence is now available that antagonism of angiotensin II (Ang II) with both angiotensin-converting enzyme inhibitors and Ang II receptor antagonists (AIIAs) is effective in slowing the rate of renal functional loss in patients affected by proteinuric kidney diseases. Among AIIAs, telmisartan has been shown to be characterised by a potent and long lasting antihypertensive effect that may be associated with another specific effect of this molecule, the partial agonism of the peroxisome-activated receptor-gamma. Although this action has also been observed with other AIIAs, telmisartan seems to exert a more effective and specific action as in such a way to influence beneficially adipocyte metabolism, diabetes onset and insulin resistance. Recently, we have demonstrated, at the experimental and clinical level, that sustained blockade of Ang II biological activity with this class of compounds can potentially reduce the progression of renal dysfunction and in some circumstances induce the regression of renal functional and structural changes. In this review we analyse available experimental and clinical data that suggest that blocking Ang II with telmisartan may effectively ameliorate renal dysfunction in patients affected by the now frequently observed condition termed metabolic syndrome.
C1 Mario Negri Inst Pharmacol Res, Dept Biomed Engn, I-24125 Bergamo, Italy.
   Osped Riuniti Bergamo, Unit Nephrol & Dialysis, I-24128 Bergamo, Italy.
C3 Istituto di Ricerche Farmacologiche Mario Negri IRCCS; Ospedali Riuniti
   di Bergamo
RP Remuzzi, A (corresponding author), Mario Negri Inst Pharmacol Res, Dept Biomed Engn, Via Gavazzeni 11, I-24125 Bergamo, Italy.
EM aremuzzi@marionegri.it
RI Remuzzi, Giuseppe/V-9766-2017; Remuzzi, Andrea/F-2409-2015
OI Remuzzi, Giuseppe/0000-0002-6194-3446; Remuzzi,
   Andrea/0000-0002-4301-8927
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NR 42
TC 11
Z9 12
U1 0
U2 3
PU J R A A S LTD
PI BIRMINGHAM
PA EDGBASTON HOUSE, 3 DUCHESS PLACE, EDGBASTON, BIRMINGHAM B16 8NH, ENGLAND
SN 1470-3203
J9 J RENIN-ANGIO-ALDO S
JI J. Renin-Angiotensin-Aldosterone Syst.
PD DEC
PY 2006
VL 7
IS 4
BP 185
EP 191
DI 10.3317/jraas.2006.036
PG 7
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 141XK
UT WOS:000244612200001
PM 17318786
DA 2025-06-11
ER

PT J
AU Utumatwishima, JN
   Baker, RL
   Bingham, BA
   Chung, ST
   Berrigan, D
   Sumner, AE
AF Utumatwishima, Jean N.
   Baker, Rafeal L., Jr.
   Bingham, Brianna A.
   Chung, Stephanie T.
   Berrigan, David
   Sumner, Anne E.
TI Stress Measured by Allostatic Load Score Varies by Reason for
   Immigration: The Africans in America Study
SO JOURNAL OF RACIAL AND ETHNIC HEALTH DISPARITIES
LA English
DT Article
DE Stress; Allostatic load score; Immigrants; African immigrants;
   Biomarkers
ID NUTRITION EXAMINATION SURVEY; INSULIN-RESISTANCE; NATIONAL-HEALTH;
   ETHNIC-DIFFERENCES; METABOLIC SYNDROME; ALL-CAUSE; RISK; TRIGLYCERIDE;
   PATTERNS; MEN
AB Objective Reason for immigration as a biological stress has not been studied in Africans. Our goal was to determine in African immigrants, if biological stress measured by allostatic load score (ALS) varies by reason for immigration.
   Methods Using an ALS which had been previously developed with the National Health and Nutrition Examination Survey (NHANES) data to assess stress due to racism and nativity, ALS was calculated in 85 African immigrants (67% male, age 42 +/- 10 years). For confirmation, we tested five additional ALS also built from NHANES.
   Results The two reasons for immigration which consistently had the lowest ALS were family reunification and lottery winner for self and immediate family. The other reasons for immigration such as study, asylum/refugee, and work had higher ALS. As reasons for immigration with the lowest ALS promoted family unity, they were combined (group 1) and the Africans who came for other reasons were combined (group 2). ALS in group 1 vs. group 2 was 1.96 +/- 1.40 vs. 2.94 +/- 1.87, P = 0.03.
   Conclusions Biological stress varies by reason for immigration and appears to be mitigated by maintaining family unity. Overall, reason for immigration is an important biographical data likely to influence health.
C1 [Utumatwishima, Jean N.; Baker, Rafeal L., Jr.; Bingham, Brianna A.; Chung, Stephanie T.; Sumner, Anne E.] NIDDK, Sect Ethn & Hlth, Diabet Endocrinol & Obes Branch, NIH, Bld 10 CRC,Rm 6-5940,MSC 1612,9000 Rockville Pike, Bethesda, MD 20892 USA.
   [Berrigan, David] NCI, Hlth Behav Res Branch, Div Canc Control & Populat Sci, NIH, Bethesda, MD 20892 USA.
   [Sumner, Anne E.] Natl Inst Minor Hlth & Hlth Dispar, NIH, Bethesda, MD 20892 USA.
C3 National Institutes of Health (NIH) - USA; NIH National Institute of
   Diabetes & Digestive & Kidney Diseases (NIDDK); National Institutes of
   Health (NIH) - USA; NIH National Cancer Institute (NCI); NIH Division of
   Cancer Control & Population Sciences; National Institutes of Health
   (NIH) - USA; NIH National Institute on Minority Health & Health
   Disparities (NIMHD)
RP Sumner, AE (corresponding author), NIDDK, Sect Ethn & Hlth, Diabet Endocrinol & Obes Branch, NIH, Bld 10 CRC,Rm 6-5940,MSC 1612,9000 Rockville Pike, Bethesda, MD 20892 USA.; Sumner, AE (corresponding author), Natl Inst Minor Hlth & Hlth Dispar, NIH, Bethesda, MD 20892 USA.
EM annes@intra.niddk.nih.gov
RI Berrigan, David/AAF-1576-2020
OI Berrigan, David/0000-0002-5333-179X
FU intramural program of the National Institute of Diabetes and Digestive
   and Kidney Diseases, National Institutes of Health; extramural program
   of the National Cancer Institute; intramural program of the National
   Institute of Minority Health and Health Disparities; Intramural Program
   of the National Institutes of Health;  [99-DK-0002]
FX Author Jean N. Utumatwishima, author Rafeal L. Baker, Jr., author
   Brianna A. Bingham, author Stephanie T. Chung, and author Anne E. Sumner
   were supported by the intramural program of the National Institute of
   Diabetes and Digestive and Kidney Diseases, National Institutes of
   Health. Author David Berrigan is supported by the extramural program of
   the National Cancer Institute. Author Jean N. Utumatwishima and author
   Anne E. Sumner are also supported by the intramural program of the
   National Institute of Minority Health and Health Disparities. The
   organization which sponsored the research is the Intramural Program of
   the National Institutes of Health. The grant number/intramural study
   protocol is 99-DK-0002.
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NR 34
TC 15
Z9 19
U1 0
U2 10
PU SPRINGER INTERNATIONAL PUBLISHING AG
PI CHAM
PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND
SN 2197-3792
EI 2196-8837
J9 J RACIAL ETHN HEALTH
JI J. Racial Ethn. Health Disparities
PD APR
PY 2018
VL 5
IS 2
BP 279
EP 286
DI 10.1007/s40615-017-0368-7
PG 8
WC Public, Environmental & Occupational Health
WE Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA GC0DV
UT WOS:000429448000007
PM 28444629
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Salminen, A
   Ojala, J
   Kaarniranta, K
   Kauppinen, A
AF Salminen, Antero
   Ojala, Johanna
   Kaarniranta, Kai
   Kauppinen, Anu
TI Mitochondrial dysfunction and oxidative stress activate inflammasomes:
   impact on the aging process and age-related diseases
SO CELLULAR AND MOLECULAR LIFE SCIENCES
LA English
DT Review
DE Ageing; Autophagy; Inflammasome; Inflammation; NF-kappa B; NLRP3
ID NF-KAPPA-B; THIOREDOXIN-BINDING PROTEIN-2; NLRP3 INFLAMMASOME;
   UNCOUPLING PROTEIN-2; IMMUNE-SYSTEM; EXPRESSION PROFILES; NALP3
   INFLAMMASOME; MOLECULAR PLATFORM; NITRIC-OXIDE; LIFE-SPAN
AB Oxidative stress and low-grade inflammation are the hallmarks of the aging process and are even more enhanced in many age-related degenerative diseases. Mitochondrial dysfunction and oxidative stress can provoke and potentiate inflammatory responses, but the mechanism has remained elusive. Recent studies indicate that oxidative stress can induce the assembly of multiprotein inflammatory complexes called the inflammasomes. Nod-like receptor protein 3 (NLRP3) is the major immune sensor for cellular stress signals, e.g., reactive oxygen species, ceramides, and cathepsin B. NLRP3 activation triggers the caspase-1-mediated maturation of the precursors of IL-1 beta and IL-18 cytokines. During aging, the autophagic clearance of mitochondria declines and dysfunctional mitochondria provoke chronic oxidative stress, which disturbs the cellular redox balance. Moreover, increased NF-kappa B signaling observed during aging could potentiate the expression of NLRP3 and cytokine proforms enhancing the priming of NLRP3 inflammasomes. Recent studies have demonstrated that NLRP3 activation is associated with several age-related diseases, e.g., the metabolic syndrome. We will review here the emerging field of inflammasomes in the appearance of the proinflammatory phenotype during the aging process and in age-related diseases.
C1 [Salminen, Antero; Ojala, Johanna] Univ Eastern Finland, Dept Neurol, Inst Clin Med, FIN-70211 Kuopio, Finland.
   [Salminen, Antero] Kuopio Univ Hosp, Dept Neurol, FIN-70211 Kuopio, Finland.
   [Kaarniranta, Kai; Kauppinen, Anu] Univ Eastern Finland, Dept Ophthalmol, Inst Clin Med, FIN-70211 Kuopio, Finland.
   [Kaarniranta, Kai] Kuopio Univ Hosp, Dept Ophthalmol, FIN-70211 Kuopio, Finland.
C3 University of Eastern Finland; Kuopio University Hospital; University of
   Eastern Finland; Kuopio University Hospital
RP Salminen, A (corresponding author), Univ Eastern Finland, Dept Neurol, Inst Clin Med, POB 1627, FIN-70211 Kuopio, Finland.
EM antero.salminen@uef.fi
OI Ojala, Johanna/0000-0002-8528-1387; Kaarniranta, Kai/0000-0003-2600-8679
FU Academy of Finland; University of Eastern Finland, Kuopio, Finland
FX This study was financially supported by Grants from the Academy of
   Finland and the University of Eastern Finland, Kuopio, Finland. The
   authors thank Dr. Ewen MacDonald for checking the language of the
   manuscript.
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NR 168
TC 229
Z9 241
U1 1
U2 39
PU SPRINGER BASEL AG
PI BASEL
PA PICASSOPLATZ 4, BASEL, 4052, SWITZERLAND
SN 1420-682X
EI 1420-9071
J9 CELL MOL LIFE SCI
JI Cell. Mol. Life Sci.
PD SEP
PY 2012
VL 69
IS 18
BP 2999
EP 3013
DI 10.1007/s00018-012-0962-0
PG 15
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA 995VI
UT WOS:000308041500002
PM 22446749
OA Green Published
DA 2025-06-11
ER

PT J
AU Rana, N
   Singh, SK
   Banu, NA
   Hjazi, A
   Vamanu, E
   Singh, MP
AF Rana, Neha
   Singh, Sandeep Kumar
   Banu, Najitha A.
   Hjazi, Ahmed
   Vamanu, Emanuel
   Singh, Mahendra P.
TI The Ethnopharmacological Properties of Green-Engineered Metallic
   Nanoparticles against Metabolic Disorders
SO MEDICINA-LITHUANIA
LA English
DT Review
DE metabolic disorders; green synthesis; metallic nanoparticles;
   nano-formulation; plant-based nanomedicine
ID MEDIATED SILVER NANOPARTICLES; GOLD NANOPARTICLES; ENHANCED
   PERMEABILITY; DISRUPTING CHEMICALS; INSULIN-RESISTANCE; OXIDATIVE
   STRESS; DRUG-DELIVERY; EXTRACT; CANCER; MANAGEMENT
AB Metabolic syndrome is a multifaceted pathophysiologic condition that is largely caused by an imbalance between caloric intake and energy expenditure. The pathogenesis of metabolic syndrome is determined by an individual's genetic/epigenetics and acquired factors. Natural compounds, notably plant extracts, have antioxidant, anti-inflammatory, and insulin-sensitizing properties and are considered to be a viable option for metabolic disorder treatment due to their low risk of side effects. However, the limited solubility, low bioavailability, and instability of these botanicals hinder their performance. These specific limitations have prompted the need for an efficient system that reduces drug degradation and loss, eliminates unwanted side effects, and boosts drug bioavailability, as well as the percentage of the drug deposited in the target areas. The quest for an enhanced (effective) drug delivery system has led to the formation of green-engineered nanoparticles, which has increased the bioavailability, biodistribution, solubility, and stability of plant-based products. The unification of plant extracts and metallic nanoparticles has helped in the development of new therapeutics against metabolic disorders such as obesity, diabetes mellitus, neurodegenerative disorders, non-alcoholic fatty liver, and cancer. The present review outlines the pathophysiology of metabolic diseases and their cures with plant-based nanomedicine.
C1 [Rana, Neha; Banu, Najitha A.] Lovely Profess Univ, Sch Bioengn & Biosci, Phagwara 144411, India.
   [Singh, Sandeep Kumar] Indian Sci Educ & Technol Fdn, Lucknow 226002, India.
   [Hjazi, Ahmed] Prince Sattam bin Adulaziz Univ, Coll Appl Med Sci, Dept Med Lab Sci, Al Kharj 11942, Saudi Arabia.
   [Vamanu, Emanuel] Univ Agr Sci & Vet Med, Fac Biotechnol, Bucharest 011464, Romania.
   [Singh, Mahendra P.] DDU Gorakhpur Univ, Dept Zool, Gorakhpur 273009, India.
   [Singh, Mahendra P.] DDU Gorakhpur Univ, Ctr Genom & Bioinformat, Gorakhpur 273009, India.
C3 Lovely Professional University; University of Agronomic Science &
   Veterinary Medicine - Bucharest; Deen Dayal Upadhyaya Gorakhpur
   University; Deen Dayal Upadhyaya Gorakhpur University
RP Banu, NA (corresponding author), Lovely Profess Univ, Sch Bioengn & Biosci, Phagwara 144411, India.; Vamanu, E (corresponding author), Univ Agr Sci & Vet Med, Fac Biotechnol, Bucharest 011464, Romania.; Singh, MP (corresponding author), DDU Gorakhpur Univ, Dept Zool, Gorakhpur 273009, India.; Singh, MP (corresponding author), DDU Gorakhpur Univ, Ctr Genom & Bioinformat, Gorakhpur 273009, India.
EM sandeeps.bhu@gmail.com; najitha.21553@lpu.co.in; email@emanuelvamanu.ro;
   mprataps01@gmail.com
RI Singh, Sandeep/HNR-1589-2023; Vamanu, Emanuel/E-9084-2012; SINGH,
   MAHENDRA PRATAP/W-5690-2019; Hjazi, Ahmed/HLH-4596-2023
OI Banu, Dr.A.Najitha/0000-0002-3847-0441; Hjazi,
   Ahmed/0009-0006-5207-5487; Vamanu, Emanuel/0000-0002-3376-2058; Singh,
   Sandeep Kumar/0000-0002-0022-6240; Hjazi, Ahmad/0009-0008-5429-2519;
   SINGH, MAHENDRA PRATAP/0000-0002-6237-7191; Hjazi,
   Ahmed/0000-0002-1129-6930
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NR 157
TC 5
Z9 5
U1 1
U2 4
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1010-660X
EI 1648-9144
J9 MEDICINA-LITHUANIA
JI Med. Lith.
PD JUN
PY 2023
VL 59
IS 6
AR 1022
DI 10.3390/medicina59061022
PG 21
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA K3DU6
UT WOS:001015285000001
PM 37374226
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Tanaka, A
   Takeuchi, K
   Furuta, M
   Takeshita, T
   Suma, S
   Shinagawa, T
   Shimazaki, Y
   Yamashita, Y
AF Tanaka, Akihiko
   Takeuchi, Kenji
   Furuta, Michiko
   Takeshita, Toru
   Suma, Shino
   Shinagawa, Takashi
   Shimazaki, Yoshihiro
   Yamashita, Yoshihisa
TI Relationship of toothbrushing to metabolic syndrome in middle-aged
   adults
SO JOURNAL OF CLINICAL PERIODONTOLOGY
LA English
DT Article
DE epidemiology; lifestyle-related diseases; oral health behaviour; oral
   hygiene; periodontitis; retrospective cohort study
ID PERIODONTAL-DISEASE; OXIDATIVE STRESS; ORAL-HEALTH; ASSOCIATION; COHORT
AB Aim: To examine the effect of toothbrushing on the development of metabolic syndrome (MetS), including assessment of periodontal status, in middle-aged adults.
   Methods: This 5-year follow-up retrospective study was performed in 3,722 participants (2,897 males and 825 females) aged 35-64 years who underwent both medical check-ups and dental examinations. Metabolic components included obesity, elevated triglycerides, blood pressure, fasting glucose and reduced high-density lipoprotein. Toothbrushing frequency was assessed using a questionnaire. Periodontal disease was defined as having at least one site with a pocket depth of >= 4 mm. Logistic regression analysis was performed to evaluate the relationship between toothbrushing frequency at the baseline examination and the development of MetS (>= 3 components).
   Results: During follow-up, 11.1% of participants developed MetS. After adjusting for potential confounders including periodontal disease, participants with more frequent daily toothbrushing tended to have significantly lower odds of developing MetS (p for trend=.01). The risk of development of MetS was significantly lower in participants brushing teeth >= 3 times/day than in those brushing teeth <= 1 time/day (odds ratio=0.64, 95% confidence interval = 0.45-0.92).
   Conclusions: Frequent daily toothbrushing was associated with lower risk of development of MetS.
C1 [Tanaka, Akihiko; Takeuchi, Kenji; Furuta, Michiko; Takeshita, Toru; Suma, Shino; Yamashita, Yoshihisa] Kyushu Univ, Fac Dent Sci, Div Oral Hlth Growth & Dev, Sect Prevent & Publ Hlth Dent, Fukuoka, Japan.
   [Takeshita, Toru] Kyushu Univ, Fac Dent Sci, OBT Res Ctr, Fukuoka, Japan.
   [Shinagawa, Takashi] Heisei Yokohama Hosp, Yokohama, Kanagawa, Japan.
   [Shimazaki, Yoshihiro] Aichi Gakuin Univ, Sch Dent, Dept Prevent Dent & Dent Publ Hlth, Nagoya, Aichi, Japan.
C3 Kyushu University; Kyushu University; Aichi Gakuin University
RP Yamashita, Y (corresponding author), Kyushu Univ, Fac Dent Sci, Div Oral Hlth Growth & Dev, Sect Prevent & Publ Hlth Dent, Fukuoka, Japan.
EM yoshi@dent.kyushu-u.ac.jp
RI Suma, Shino/MSV-6497-2025; Takeshita, Toru/AAT-2321-2021; Takeuchi,
   Kenji/E-9922-2013
OI Takeuchi, Kenji/0000-0001-8769-8955
FU Ministry of Education, Science, Sports, and Culture of Japan, Tokyo,
   Japan Ministry of Education, Culture, Sports, Science and Technology of
   Japan [17K17375, 26861832]; Grants-in-Aid for Scientific Research
   [26861832, 17K17375] Funding Source: KAKEN
FX This study was supported by Grant-in-Aid for Young Scientists (B)
   (17K17375 and 26861832) from the Ministry of Education, Science, Sports,
   and Culture of Japan, Tokyo, Japan Ministry of Education, Culture,
   Sports, Science and Technology of Japan.
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NR 33
TC 16
Z9 17
U1 0
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0303-6979
EI 1600-051X
J9 J CLIN PERIODONTOL
JI J. Clin. Periodontol.
PD MAY
PY 2018
VL 45
IS 5
BP 538
EP 547
DI 10.1111/jcpe.12876
PG 10
WC Dentistry, Oral Surgery & Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dentistry, Oral Surgery & Medicine
GA GF5LR
UT WOS:000432009300003
PM 29421856
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Li, RY
   Cao, ZG
   Li, Y
   Wang, RT
AF Li, Rui-yan
   Cao, Zhi-gang
   Li, Ying
   Wang, Rui-tao
TI Increased whole blood viscosity is associated with silent cerebral
   infarction
SO CLINICAL HEMORHEOLOGY AND MICROCIRCULATION
LA English
DT Article
DE Silent cerebral infarction; whole blood viscosity; risk factors;
   atherosclerosis
ID WALL SHEAR-STRESS; BRAIN INFARCTS; METABOLIC SYNDROME; CAROTID-ARTERY;
   RISK-FACTORS; ATHEROSCLEROSIS; DISORDERS; LESIONS; STROKE; FLOW
AB BACKGROUND: The presence of silent cerebral infarction (SCI) increases the risk of transient ischemia attack, symptomatic stroke, cardiovascular disease and dementia. Increased viscosity is associated with aging, obesity, carotid intima-media thickness, metabolic syndrome, hypertension, diabetes, ischemic heart disease, and stroke.
   AIMS: The purpose of the study was to assess the hemorheological parameters levels in SCI patients.
   METHODS: A cross-sectional study was conducted to evaluate the association between hemorheological parameters and SCI in 1487 subjects (868 men and 619 women) undergoing medical check-up.
   RESULTS: The participants with SCI had higher whole blood viscosity (WBV) levels at low shear rate than those without SCI (10.34 +/- 1.77mPa.s vs. 8.98 +/- 0.88mPa.s; P < 0.001). Moreover, the subjects with a high WBV had a higher prevalence of SCI. Logistic regression analysis revealed that a significant association of WBV levels with the risk of SCI after adjustment for confounding factors (OR: 2.025; 95% CI: 1.750-2.343; P < 0.001).
   CONCLUSIONS: Whole blood viscosity at low shear rate is a novel indicator for SCI regardless of classical cardiovascular risk factors. Early measurement of whole blood viscosity may be helpful to assess the risk of stroke.
C1 [Li, Rui-yan] Harbin Med Univ, Affiliated Hosp 2, Dept Neurosurg, Harbin 150086, Heilongjiang, Peoples R China.
   [Cao, Zhi-gang] Harbin Med Univ, Affiliated Hosp 2, Dept Intervent Radiol, Harbin 150086, Heilongjiang, Peoples R China.
   [Li, Ying; Wang, Rui-tao] Harbin Med Univ, Affiliated Hosp 2, Dept Geriatr, Harbin 150086, Heilongjiang, Peoples R China.
   [Li, Ying] Harbin Med Univ, Affiliated Hosp 2, Int Phys Examinat & Hlth Ctr, Harbin 150086, Heilongjiang, Peoples R China.
C3 Harbin Medical University; Harbin Medical University; Harbin Medical
   University; Harbin Medical University
RP Wang, RT (corresponding author), Harbin Med Univ, Affiliated Hosp 2, Dept Geriatr, 246 Xuefu ST, Harbin 150086, Heilongjiang, Peoples R China.
EM ruitao_wang@yahoo.cn
FU Heilongjiang provincial government postdoctoral science foundation
   [LBH-Z11060]; Natural Science Foundation of Heilongjiang Province of
   China [LC 201005]
FX This study was supported by the Heilongjiang provincial government
   postdoctoral science foundation (LBH-Z11060) and Natural Science
   Foundation of Heilongjiang Province of China (No. LC 201005).
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NR 21
TC 35
Z9 36
U1 0
U2 11
PU IOS PRESS
PI AMSTERDAM
PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS
SN 1386-0291
EI 1875-8622
J9 CLIN HEMORHEOL MICRO
JI Clin. Hemorheol. Microcirc.
PY 2015
VL 59
IS 4
BP 301
EP 307
DI 10.3233/CH-131760
PG 7
WC Hematology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Hematology; Cardiovascular System & Cardiology
GA CJ0WX
UT WOS:000355201300002
PM 23988733
DA 2025-06-11
ER

PT J
AU Park, KH
   Kim, KJ
   Lee, BW
   Kang, ES
   Cha, BS
   Lee, HC
AF Park, Kyeong Hye
   Kim, Kwang Joon
   Lee, Byung-Wan
   Kang, Eun Seok
   Cha, Bong Soo
   Lee, Hyun Chul
TI The effect of insulin resistance on postprandial triglycerides in Korean
   type 2 diabetic patients
SO ACTA DIABETOLOGICA
LA English
DT Article
DE Postprandial triglyceride; Insulin resistance; Metabolic syndrome;
   Diabetes mellitus
ID IMPAIRED GLUCOSE-TOLERANCE; ENDOTHELIAL DYSFUNCTION; OXIDATIVE STRESS;
   FASTING GLUCOSE; LIPEMIA; YOUNG; RISK; FAT; LIPOPROTEINS; DIETARY
AB We hypothesized that the influence of metabolic parameters depends on metabolic syndrome (MetS) status. The clinical and metabolic implications of postprandial triglyceride (ppTG) in Korean type 2 diabetes were investigated in the presence or absence of MetS, MetS+, or MetS-. To investigate the relationship between ppTG and metabolic parameters, we analyzed plasma TG levels in 126 newly diagnosed, drug-na < ve diabetic patients after ingestion of a standardized low calorie and fat (500 kcal, 17.5 g fat) liquid meal formula. We report that MetS+ patients have significantly higher BMI, waist/hip ratio, HOMA-IR, and HOMA-beta, but insignificantly higher fasting TG, ppTG, and Delta TG than MetS- patients. In the MetS+ patients, ppTG correlated with fasting TG and non-HDL, but was not related to HOMA-IR. In MetS- patients, ppTG correlated with fasting TG, non-HDL, blood pressure, waist/hip ratio, fasting C-peptide and insulin levels, and HOMA-IR. Multivariate analysis showed HOMA-IR to be a predictive factor for ppTG in MetS- patients but not in MetS+ patients. ppTG correlated with IR in MetS- type 2 diabetic patients but not in MetS+. This unexpected result implies that MetS+ diabetic patients already have high fasting TG and that IR influences fasting TG more dominantly than ppTG.
C1 [Park, Kyeong Hye; Kim, Kwang Joon; Lee, Byung-Wan; Kang, Eun Seok; Cha, Bong Soo; Lee, Hyun Chul] Yonsei Univ, Coll Med, Dept Internal Med, Div Endocrinol & Metab, Seoul 120752, South Korea.
   [Kim, Kwang Joon] Yonsei Univ Hlth Syst, Severance Execut Healthcare Clin, Seoul, South Korea.
C3 Yonsei University; Yonsei University Health System; Yonsei University;
   Yonsei University Health System
RP Lee, BW (corresponding author), Yonsei Univ, Coll Med, Dept Internal Med, Div Endocrinol & Metab, 50 Yonsei Ro, Seoul 120752, South Korea.
EM bwanlee@yuhs.ac
RI Wan, Lee/K-2649-2019; Lee, YoungMi/JCF-0461-2023
OI Cha, Bong-Soo/0000-0003-0542-2854; Lee, Byung-Wan/0000-0002-9899-4992;
   Kang, Eun Seok/0000-0002-0364-4675
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NR 31
TC 3
Z9 3
U1 0
U2 4
PU SPRINGER-VERLAG ITALIA SRL
PI MILAN
PA VIA DECEMBRIO, 28, MILAN, 20137, ITALY
SN 0940-5429
EI 1432-5233
J9 ACTA DIABETOL
JI Acta Diabetol.
PD FEB
PY 2014
VL 51
IS 1
BP 15
EP 22
DI 10.1007/s00592-012-0420-3
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA AB1IX
UT WOS:000331545800003
PM 22854916
DA 2025-06-11
ER

PT J
AU Carallo, C
   Mancuso, G
   Mauro, G
   Laghi, F
   Madafferi, B
   Irace, C
   Gnasso, A
   Scavelli, F
   Dell'Aquila, F
   Bartone, M
   Gullo, F
   Ferraro, M
   Spagnuolo, V
   Belmonte, M
   Ferrara, A
   Rotondaro, AS
   Brandolino, N
   Parasporo, F
   Scopelliti, F
AF Carallo, Claudio
   Mancuso, Gerardo
   Mauro, Gaetano
   Laghi, Ferdinando
   Madafferi, Bruno
   Irace, Concetta
   Gnasso, Agostino
   Scavelli, Faustina
   Dell'Aquila, Ferruccio
   Bartone, Mose
   Gullo, Francesco
   Ferraro, Maria
   Spagnuolo, Vitaliano
   Belmonte, Maria
   Ferrara, Antonio
   Rotondaro, Antonio Silvano
   Brandolino, Nicola
   Parasporo, Francesca
   Scopelliti, Francesco
TI Hepatic steatosis, carotid atherosclerosis and metabolic syndrome: the
   STEATO Study
SO JOURNAL OF GASTROENTEROLOGY
LA English
DT Article
DE Fatty liver; Metabolic liver disease; Carotid artery disease; Carotid
   plaques; Echo-Doppler
ID NONALCOHOLIC FATTY LIVER; GAMMA-GLUTAMYL-TRANSFERASE;
   INSULIN-RESISTANCE; CARDIOVASCULAR-DISEASE; ALANINE AMINOTRANSFERASE;
   ENDOTHELIAL DYSFUNCTION; OXIDATIVE STRESS; RISK; HEART; EVENTS
AB Hepatic steatosis is frequently observed in subjects with metabolic syndrome (MS). In type 2 diabetics, it is independently associated with cardiovascular diseases. In order to confirm and extend this finding, a large group of patients with risk factors for atherosclerosis was studied.
   Carotid atherosclerosis was investigated by echo-Doppler, and hepatic steatosis by ultrasound and transaminase values. Strict exclusion criteria were chosen in order to avoid secondary forms of fatty liver and interference on transaminase values.
   Among 970 enrolled patients, about 20% were diabetics, half had MS and 76% presented echographic hepatic steatosis. In multivariate analyses, fatty liver and MS were associated with carotid atherosclerosis [odds ratio (95% confidence intervals) 2.15 (1.27-3.63) and 1.72 (1.12-2.64), respectively], whereas HOMA index was not. Aspartate aminotransferase and alanine aminotransferase were not independently associated with carotid atherosclerosis, whereas gamma-glutamyl transferase showed a link with atherosclerosis beyond MS and steatosis presence. The analyses of the 780 non diabetics recruited showed similar results.
   The results of the present study demonstrate that hepatic steatosis measured by echography is associated with carotid atherosclerosis in a large population mostly carrying cardiovascular or metabolic risk factors, independently of MS, cardiovascular diseases, diabetes mellitus and/or insulin resistance.
C1 [Carallo, Claudio; Irace, Concetta; Gnasso, Agostino; Scavelli, Faustina; Dell'Aquila, Ferruccio] Magna Graecia Univ Catanzaro, Dept Clin & Expt Med G Salvatore, Metab Dis Unit, I-88100 Catanzaro, Italy.
   [Mancuso, Gerardo; Bartone, Mose; Gullo, Francesco] Gen Hosp, Internal Med Unit, Catanzaro, Italy.
   [Mauro, Gaetano; Laghi, Ferdinando; Ferraro, Maria; Spagnuolo, Vitaliano; Belmonte, Maria; Ferrara, Antonio; Rotondaro, Antonio Silvano] Gen Hosp, Internal Med Unit, Cosenza, Italy.
   [Madafferi, Bruno; Brandolino, Nicola; Parasporo, Francesca; Scopelliti, Francesco] Gen Hosp, Internal Med Unit, Reggio Di Calabria, Italy.
C3 Magna Graecia University of Catanzaro
RP Gnasso, A (corresponding author), Magna Graecia Univ Catanzaro, Dept Clin & Expt Med G Salvatore, Metab Dis Unit, Viale Europa, I-88100 Catanzaro, Italy.
EM gnasso@unicz.it
RI Irace, Concetta/AAC-7796-2022; Santilli, Francesca/ABC-6243-2021;
   Giancaterini, Francesco/HJI-1305-2023
OI IRACE, Concetta/0000-0001-5182-5473; Carallo,
   Claudio/0000-0002-3958-3245
CR Bloomgarden ZT, 2005, DIABETES CARE, V28, P1518, DOI 10.2337/diacare.28.6.1518
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NR 32
TC 13
Z9 15
U1 0
U2 6
PU SPRINGER JAPAN KK
PI TOKYO
PA SHIROYAMA TRUST TOWER 5F, 4-3-1 TORANOMON, MINATO-KU, TOKYO, 105-6005,
   JAPAN
SN 0944-1174
EI 1435-5922
J9 J GASTROENTEROL
JI J. Gastroenterol.
PD NOV
PY 2009
VL 44
IS 11
BP 1156
EP 1161
DI 10.1007/s00535-009-0125-8
PG 6
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 518ZK
UT WOS:000271734600009
PM 19802520
DA 2025-06-11
ER

PT J
AU Yahyazadeh, R
   Rahbardar, MG
   Razavi, BM
   Karimi, G
   Hosseinzadeh, H
AF Yahyazadeh, Roghayeh
   Rahbardar, Mahboobeh Ghasemzadeh
   Razavi, Bibi Marjan
   Karimi, Gholamreza
   Hosseinzadeh, Hossein
TI The effect of Elettaria cardamomum (cardamom) on the
   metabolic Narrative review
SO IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
LA English
DT Review
DE Anti-inflammatory agents; Anti-oxidants; Elettaria cardamomum;
   Hypoglycemic agents; Hypolipidemic agents; Metabolic syndrome
ID NF-KAPPA-B; OXIDATIVE STRESS; INSULIN-RESISTANCE; ALPHA-TERPINEOL; POMC
   NEURONS; L. MATON; OBESITY; SIRT1; ANTIOXIDANT; INFLAMMATION
AB Metabolic syndrome (MetS), as a health-threatening factor, consists of various symptoms including insulin resistance, high blood sugar, hypertension, dyslipidemia, inflammation, and abdominal obesity that raise the risk of diabetes mellitus and cardiovascular disease. Cardiovascular diseases are important causes of mortality among the world population. Recently, there has been a growing interest in using phytomedicine and natural compounds in the prevention and treatment of various diseases. The data was gathered by searching various standard electronic databases (Google Scholar, Scopus, Web of Science, and PubMed) for English articles with no time limitations. All in vivo, in vitro, and clinical studies were included. Elettaria cardamomum (cardamom) is a rich source of phenolic compounds, volatile oils, and fixed oils. Cardamom and its pharmacologically effective substances have shown broad-spectrum activities including antihypertensive, anti-oxidant, lipid-modifying, anti-inflammatory, anti-atherosclerotic, anti-thrombotic, hepatoprotective, hypocholesterolemic, anti-obesity, and antidiabetic effects. This review aims to highlight the therapeutic effects of cardamom on MetS and its components including diabetes, hyperlipidemia, obesity, and high blood pressure as well as the underlying mechanisms in the management of MetS. Finally, it can be stated that cardamom has beneficial effects on the treatment of MetS and its complications.
C1 [Yahyazadeh, Roghayeh; Razavi, Bibi Marjan; Karimi, Gholamreza; Hosseinzadeh, Hossein] Mashhad Univ Med Sci, Sch Pharm, Dept Pharmacodynam & Toxicol, Mashhad, Razavi Khorasan, Iran.
   [Rahbardar, Mahboobeh Ghasemzadeh; Karimi, Gholamreza; Hosseinzadeh, Hossein] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Pharmaceut Res Ctr, Mashhad, Razavi Khorasan, Iran.
   [Razavi, Bibi Marjan] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Targeted Drug Delivery Res Ctr, Mashhad, Razavi Khorasan, Iran.
C3 Mashhad University of Medical Sciences; Mashhad University of Medical
   Sciences; Mashhad University of Medical Sciences
RP Hosseinzadeh, H (corresponding author), Mashhad Univ Med Sci, Pharmaceut Technol Inst, Pharmaceut Res Ctr, Mashhad, Razavi Khorasan, Iran.
EM hosseinzadehh@mums.ac.ir
RI Hosseinzadeh, Hossein/F-3013-2010; Ghasemzadeh Rahbardar,
   Mahboobeh/V-4452-2019; karimi, gholamreza/B-8726-2017; Razavi,
   Bibi/AAY-5636-2020
OI Ghasemzadeh Rahbardar, Mahboobeh/0000-0002-5491-572X
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NR 84
TC 28
Z9 29
U1 0
U2 4
PU MASHHAD UNIV MED SCIENCES
PI MASHHAD
PA VICE-CHANCELLOR FOR RES CTR OFF IJBMS, DANESHGAH ST, PO BOX 9138813944 -
   445, MASHHAD, 00000, IRAN
SN 2008-3866
EI 2008-3874
J9 IRAN J BASIC MED SCI
JI Iran. J. Basic Med. Sci.
PD NOV
PY 2021
VL 24
IS 11
BP 1462
EP 1469
DI 10.22038/IJBMS.2021.54417.12228
PG 8
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA WS0LV
UT WOS:000714882700001
PM 35317114
DA 2025-06-11
ER

PT J
AU Tsou, YH
   Wang, B
   Ho, W
   Hu, B
   Tang, P
   Sweet, S
   Zhang, XQ
   Xu, XY
AF Tsou, Yung-Hao
   Wang, Bin
   Ho, William
   Hu, Bin
   Tang, Pei
   Sweet, Sydney
   Zhang, Xue-Qing
   Xu, Xiaoyang
TI Nanotechnology-Mediated Drug Delivery for the Treatment of Obesity and
   Its Related Comorbidities
SO ADVANCED HEALTHCARE MATERIALS
LA English
DT Review
DE adipose; diabetes; heart diseases; nanotechnology; obesity
ID PERCUTANEOUS CORONARY INTERVENTION; TYPE-2 DIABETES-MELLITUS; WHITE
   ADIPOSE-TISSUE; BODY-MASS INDEX; METABOLIC SYNDROME; BARIATRIC SURGERY;
   OXIDE NANOPARTICLES; MICRONEEDLE PATCH; OXIDATIVE STRESS;
   MYOCARDIAL-INFARCTION
AB Obesity is a serious health issue affecting humanity on a global scale. Recognized by the American Medical Association as a chronic disease, the incidence of obesity continues to grow at an accelerating rate and obesity has become one of the major threats to human health. Excessive weight gain is tied to metabolic syndrome, which is shown to increase the risk of chronic diseases, such as heart disease and type 2 diabetes, taxing an already overburdened healthcare system and increasing mortality worldwide. Available treatments such as bariatric surgery and pharmacotherapy are often accompanied by adverse side effects and poor patient compliance. Nanotechnology, an emerging technology with a wide range of biomedical applications, has provided an unprecedented opportunity to improve the treatment of many diseases, including obesity. This review provides an introduction to obesity and obesity-related comorbidities. The most recent developments of nanotechnology-based drug delivery strategies are highlighted and discussed. Additionally, challenges and consideration for the development of nanoformulations with translational potential are discussed. The overall objective of this review is to enhance the understanding of the design and development of nanomedicine for treatments of obesity and related comorbidities.
C1 [Tsou, Yung-Hao; Ho, William; Sweet, Sydney; Xu, Xiaoyang] New Jersey Inst Technol, Dept Chem & Mat Engn, Newark, NJ 07102 USA.
   [Wang, Bin; Hu, Bin; Tang, Pei; Zhang, Xue-Qing] Shanghai Jiao Tong Univ, Sch Pharm, Minist Educ, Engn Res Ctr Cell & Therapeut Antibody, 800 Dongchuan Rd, Shanghai 200240, Peoples R China.
C3 New Jersey Institute of Technology; Ministry of Education - China;
   Shanghai Jiao Tong University
RP Xu, XY (corresponding author), New Jersey Inst Technol, Dept Chem & Mat Engn, Newark, NJ 07102 USA.; Zhang, XQ (corresponding author), Shanghai Jiao Tong Univ, Sch Pharm, Minist Educ, Engn Res Ctr Cell & Therapeut Antibody, 800 Dongchuan Rd, Shanghai 200240, Peoples R China.
EM xueqingzhang@sjtu.edu.cn; xiaoyang@njit.edu
RI Xu, Xiaoyang/LSL-3763-2024; Wang, Bin/O-1322-2015
OI Ho, William/0000-0002-8329-8572; xu, xiaoyang/0000-0002-1634-3329
FU New Jersey Institute of Technology (NJIT) startup funding; New Jersey
   Health Foundation [PC102-17, ISFP 18-19, PC25-18]; American Heart
   Association [_19AIREA34380849/Xiaoyang Xu/2019]; NSF Innovation Corps
   [1723667]; Div Of Industrial Innovation & Partnersh; Directorate For
   Engineering [1723667] Funding Source: National Science Foundation
FX Y.-H.T. and B.W. contributed equally to this work. The financial support
   coming from New Jersey Institute of Technology (NJIT) startup funding,
   New Jersey Health Foundation (PC102-17, ISFP 18-19, and PC25-18), this
   work was supported by American Heart Association grant#_
   19AIREA34380849/Xiaoyang Xu/2019, and NSF Innovation Corps (1723667)
   program is gratefully acknowledged.
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NR 136
TC 27
Z9 28
U1 2
U2 85
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2192-2640
EI 2192-2659
J9 ADV HEALTHC MATER
JI Adv. Healthc. Mater.
PD JUN
PY 2019
VL 8
IS 12
SI SI
AR 1801184
DI 10.1002/adhm.201801184
PG 14
WC Engineering, Biomedical; Nanoscience & Nanotechnology; Materials
   Science, Biomaterials
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering; Science & Technology - Other Topics; Materials Science
GA IM1PD
UT WOS:000477762100010
PM 30938934
OA Bronze
DA 2025-06-11
ER

PT J
AU Forbes-Hernandez, TY
   Gasparrini, M
   Afrin, S
   Bompadre, S
   Mezzetti, B
   Quiles, JL
   Giampieri, F
   Battino, M
AF Forbes-Hernandez, Tamara Y.
   Gasparrini, Massimiliano
   Afrin, Sadia
   Bompadre, Stefano
   Mezzetti, Bruno
   Quiles, Jose L.
   Giampieri, Francesca
   Battino, Maurizio
TI The Healthy Effects of Strawberry Polyphenols: Which Strategy behind
   Antioxidant Capacity?
SO CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
LA English
DT Review
DE Strawberry; polyphenols; inflammation; metabolism; cardiovascular
   diseases; cancer
ID DIETARY FLAVONOID FISETIN; KAPPA-B PATHWAYS; GALLIC ACID; OXIDATIVE
   STRESS; CANCER CELLS; ANTIINFLAMMATORY ACTIVITY; MITOCHONDRIAL-FUNCTION;
   INDUCED INFLAMMATION; BIOACTIVE COMPOUNDS; INDUCED APOPTOSIS
AB Current evidence indicates that the consumption of strawberries, a natural source of a wide range of nutritive and bioactive compounds, is associated with the prevention and improvement of chronic-degenerative diseases. Studies involving cells and animals provide evidence on the anti-inflammatory, anticarcinogenic and antiproliferative activity of the strawberry. Epidemiological and clinical studies demonstrate that its acute consumption increases plasma antioxidant capacity, improves circulating inflammatory markers and ameliorates postprandial glycemic response. At the same time, a protracted intake reduces chronic inflammation and improves plasma lipid profile, supporting cardiovascular health, especially in individuals with increased risk for metabolic syndrome. To explain these beneficial effects, much attention has been paid in the past to the antioxidant properties of strawberry polyphenols. However, recent research has shown that their biological and functional activities are related not only to the antioxidant capacity but also to the modulation of many cellular pathways involved in metabolism, survival, proliferation, and antioxidant defenses. The aim of this review is to update and discuss the molecular and cellular mechanisms proposed in recent studies to elucidate the healthy effects of strawberry polyphenols against the most common chronic diseases, such as cancer, cardiovascular diseases, metabolic syndrome, and inflammation.
C1 [Forbes-Hernandez, Tamara Y.; Gasparrini, Massimiliano; Afrin, Sadia; Giampieri, Francesca; Battino, Maurizio] Univ Politecn Marche, Fac Med, Dipartimento Sci Clin Specialistiche & Odontostom, Sez Biochim, Ancona, Italy.
   [Forbes-Hernandez, Tamara Y.] Univ Int Iberoamer UNINI, Area Nutr & Salud, Campeche, Mexico.
   [Bompadre, Stefano] Univ Politecn Marche, Fac Med, Dipartimento Sci Biomed & Sanita Pubbl, Ancona, Italy.
   [Mezzetti, Bruno] Univ Politecn Marche, Dipartimento Sci Agr Alimentari & Ambientali, Ancona, Italy.
   [Quiles, Jose L.] Univ Granada, Biomed Res Ctr, Inst Nutr & Food Technol Jose Mataix, Dept Physiol, Granada, Spain.
   [Giampieri, Francesca; Battino, Maurizio] UEA, Ctr Nutr & Hlth, Santander, Spain.
C3 Marche Polytechnic University; Marche Polytechnic University; Marche
   Polytechnic University; University of Granada
RP Giampieri, F; Battino, M (corresponding author), Univ Politecn Marche, Fac Med, DISCO, Via Ranieri 65, I-60131 Ancona, Italy.
EM m.a.battino@univpm.it; m.a.battino@univpm.it
RI Battino, Maurizio/E-6103-2012; Mezzetti, Bruno/AAB-8500-2019; Afrin,
   Sadia/AAQ-5030-2020; Quiles, Jose L./C-6911-2013; Giampieri,
   Francesca/I-1911-2015; Forbes Hernandez, Tamara/AAB-1872-2021
OI Afrin, Sadia/0000-0001-5063-9900; Mezzetti, Bruno/0000-0001-9307-812X;
   Quiles, Jose L./0000-0002-9048-9086; Giampieri,
   Francesca/0000-0002-8151-9132; Forbes Hernandez,
   Tamara/0000-0001-7021-9276
FU Fondazione Umberto Veronesi Fellowship
FX Dr. F. Giampieri was supported by a Fondazione Umberto Veronesi
   Fellowship.
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NR 111
TC 130
Z9 130
U1 4
U2 14
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1040-8398
EI 1549-7852
J9 CRIT REV FOOD SCI
JI Crit. Rev. Food Sci. Nutr.
PY 2016
VL 56
SU 1
BP S46
EP S59
DI 10.1080/10408398.2015.1051919
PG 14
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA DR0HY
UT WOS:000379589800004
PM 26357900
DA 2025-06-11
ER

PT J
AU Yan, B
   Yan, H
   Sun, L
   Yan, X
   Peng, LY
   Wang, YH
   Wang, G
AF Yan, Bin
   Yan, Hang
   Sun, Lu
   Yan, Xin
   Peng, Liyuan
   Wang, Yuhuan
   Wang, Gang
TI Novel Association Between the Reverse-Dipper Pattern of Ambulatory Blood
   Pressure Monitoring and Metabolic Syndrome in Men But Not in Women
SO MEDICINE
LA English
DT Article
ID ARTERIAL-HYPERTENSION; INFLAMMATION; GLUCOSE; MANAGEMENT; OBESITY;
   STRESS
AB The aim of this study was to investigate the relationships between nocturnal variations in blood pressure (BP) and metabolic syndrome (MetS) in different gender.This cross-sectional study involved 509 hypertensive patients (254 males and 255 females, 45 to 75 years old) from September 2013 to March 2014. BP values were acquired from ambulatory BP monitoring (ABPM). The dipper pattern of BP was defined as 10% to 20% reduction of the mean systolic BP (SBP) values at night compared with the daytime values. The diagnosis of MetS was made according to NCEP ATP-III definition. Multivariate logistic regression analyses were used to explore the relationships between ABPM results and MetS.In our study, MetS were observed in 29.1% of male and 18.4% of female participants. The prevalence of MetS was higher in the patients with reverse-dipper pattern than in others. After multivariate logistic regression analysis, the reverse-dipper pattern of BP (odds ratio 2.298; P=0.006) and 24-SBP (odds ratio 1.063; P=0.021) were independently correlated with MetS in males. However, there was no association between MetS and BP reverse dipping in females.Our cross-sectional study showed that the reverse-dipper pattern of BP is associated with MetS in male, while the underlying mechanism deserves further investigation.
C1 [Yan, Bin; Wang, Gang] Xi An Jiao Tong Univ, Dept Emergency Med, Affiliated Hosp 2, Xian 710049, Peoples R China.
   [Yan, Hang; Wang, Yuhuan] Xi An Jiao Tong Univ, Dept Endocrinol, Affiliated Hosp 2, Xian 710049, Peoples R China.
   [Sun, Lu] Xi An Jiao Tong Univ, Dept Ultrasound, Affiliated Hosp 2, Xian 710049, Peoples R China.
   [Yan, Xin] Xi An Jiao Tong Univ, Hlth Sci Ctr, Xian 710049, Peoples R China.
   [Peng, Liyuan] Tianjin Med Univ, Sch Med, Tianjin, Peoples R China.
C3 Xi'an Jiaotong University; Xi'an Jiaotong University; Xi'an Jiaotong
   University; Xi'an Jiaotong University; Tianjin Medical University
RP Wang, G (corresponding author), Xi An Jiao Tong Univ, Dept Emergency Med, Affiliated Hosp 2, Xian 710049, Peoples R China.
EM gang_wang@mail.xjtu.edu.cn
RI Sun, Lu/L-2238-2019
FU National Natural Science Foundation of China [81300116]; Research Fund
   for the Young Scholars of the Higher Education Doctoral Program of China
   [20120201120083]; Fundamental Research Funds for the Central
   Universities of China [XJJ2013062]; Scientific Fund for the Young talent
   of Shaanxi Province [2015KJXX-06]
FX Funding for this study was provided by the National Natural Science
   Foundation of China (81300116), the Research Fund for the Young Scholars
   of the Higher Education Doctoral Program of China (20120201120083), the
   Fundamental Research Funds for the Central Universities of China
   (XJJ2013062), and the Scientific Fund for the Young talent of Shaanxi
   Province (2015KJXX-06).
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NR 29
TC 7
Z9 8
U1 0
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD NOV
PY 2015
VL 94
IS 47
AR e2115
DI 10.1097/MD.0000000000002115
PG 4
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA DC9KB
UT WOS:000369539300055
PM 26632731
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Prasanth, MI
   Gayathri, S
   Bhaskar, JP
   Krishnan, V
   Balamurugan, K
AF Prasanth, Mani Iyer
   Gayathri, Subramanyam
   Bhaskar, James Prabhanand
   Krishnan, Venkateswaran
   Balamurugan, Krishnaswamy
TI Analyzing the Synergistic Effects of Antioxidants in Combating
   Photoaging Using Model Nematode, Caenorhabditis elegans
SO PHOTOCHEMISTRY AND PHOTOBIOLOGY
LA English
DT Article
ID EXTENDS LIFE-SPAN; STRESS RESISTANCE; METABOLIC SYNDROME; CITRUS
   FLAVONOIDS; OXIDATIVE STRESS; COMBINATION; NARINGENIN; SURVIVAL;
   PATHWAY; DAF-16
AB Aging, a universal and unique process, occurs both intrinsically (chronological) and extrinsically (photoaging). Ultraviolet-A (UV-A)-mediated stress is a growing health hazard to mankind as it is the major cause of photoaging, which could lead to much damage of skin cells and tissues ranging from tan, burn, or even cancer. The present study focuses on the role of antioxidants and other natural compounds which have been widely used in oral/topical applications to combat and delay the effects of photoaging using model nematode Caenorhabditis elegans. Compounds like green tea extract, naringenin, and naringin, which are known for their antioxidant properties, were able to extend life span and healthspan of the nematode in normal as well as under UV-A-mediated stress conditions. Regulation of both the stress-responsive genes (skn-1 and sir-2.1) and the aging-regulating genes (daf-2 and age-1) was attributable for these conditions. Interestingly, it was observed that these compounds when combined in equal ratios by weight worked synergistically to combat the aging process. Pronounced synergistic effects were observed during UV-A-mediated stress conditions, suggesting that these could be used as potential antiphotoaging compounds which will be of greater significance for health-based research.
C1 [Prasanth, Mani Iyer; Balamurugan, Krishnaswamy] Alagappa Univ, Dept Biotechnol, Sci Campus, Karaikkudi, Tamil Nadu, India.
   [Gayathri, Subramanyam; Bhaskar, James Prabhanand; Krishnan, Venkateswaran] ITC Life Sci & Technol Ctr, Bengaluru, Karnataka, India.
C3 Alagappa University
RP Balamurugan, K (corresponding author), Alagappa Univ, Dept Biotechnol, Sci Campus, Karaikkudi, Tamil Nadu, India.
EM bsuryar@yahoo.com
OI Balamurugan, Prof. Dr. Krishnaswamy/0000-0001-9316-8141; PRABHANAND
   BHASKAR, JAMES/0000-0001-6648-8414
FU National Institute of Health, National Center for Research Resources;
   Department of Biotechnology (DBT); University Grants Commission (UGC);
   Indian Council of Medical Research (ICMR); Council of Scientific and
   Industrial Research (CSIR); Department of Science and Technology (DST),
   Government of India, New Delhi, India; ITC Ltd; CSIR; UGC, India;
   Department of Biotechnology, Ministry of Science and Technology,
   Government of India [BT/BI/25/015/2012]; DST, Government of India
   through PURSE [SR/S9Z-23/2010/42(G)]; DST, Government of India through
   FIST [SR-FST/LSI-087/2008]; UGC, New Delhi, through SAP-DRS1
   [F.3-28/2011(SAPII)]; UGC, New Delhi, through RUSA 2.0 [Policy (TN
   Multi-Gen), Dept of Education, GOI] [F. 24-51/2014-U]
FX We thank Caenorhabditis Genetics Center, which is funded by the National
   Institute of Health, National Center for Research Resources for
   providing C. elegans N2 WT, mutant strains, and E. coli OP50. KB
   thankfully acknowledges ITC Ltd for collaborative project and Department
   of Biotechnology (DBT), University Grants Commission (UGC), Indian
   Council of Medical Research (ICMR), Council of Scientific and Industrial
   Research (CSIR), and Department of Science and Technology (DST),
   Government of India, New Delhi, India, for the financial assistances.
   PMI wishes to thank ITC Ltd, CSIR, and UGC, India, for the financial
   assistance (AU-ITC JRF, CSIR-SRF, and UGCBSR). The authors also
   gratefully acknowledge the use of the Bioinformatics Infrastructure
   Facility, Alagappa University, funded by the Department of
   Biotechnology, Ministry of Science and Technology, Government of India
   (No. BT/BI/25/015/2012), the Instrumentation Facility provided by DST,
   Government of India through PURSE [Grant No.SR/S9Z-23/2010/42(G)] and
   FIST (Grant No.SR-FST/LSI-087/2008), and UGC, New Delhi, through
   SAP-DRS1 [Grant No. F.3-28/2011(SAPII)] and RUSA 2.0 [F. 24-51/2014-U,
   Policy (TN Multi-Gen), Dept of Education, GOI], for providing the
   instrumentation facilities.
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NR 66
TC 19
Z9 19
U1 2
U2 34
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0031-8655
EI 1751-1097
J9 PHOTOCHEM PHOTOBIOL
JI Photochem. Photobiol.
PD JAN
PY 2020
VL 96
IS 1
BP 139
EP 147
DI 10.1111/php.13167
EA OCT 2019
PG 9
WC Biochemistry & Molecular Biology; Biophysics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics
GA KD0AI
UT WOS:000491767800001
PM 31556119
DA 2025-06-11
ER

PT J
AU Tain, YL
   Hsu, CN
AF Tain, You-Lin
   Hsu, Chien-Ning
TI Melatonin Use during Pregnancy and Lactation Complicated by Oxidative
   Stress: Focus on Offspring's Cardiovascular-Kidney-Metabolic Health in
   Animal Models
SO ANTIOXIDANTS
LA English
DT Review
DE oxidative stress; hypertension; metabolic syndrome; developmental
   origins of health and disease (DOHaD); kidney disease; nitric oxide;
   melatonin; antioxidants
ID ASYMMETRIC DIMETHYLARGININE ADMA; INDUCED PROGRAMMED HYPERTENSION;
   MATERNAL NICOTINE EXPOSURE; REDUCES NEPHRON NUMBER; NITRIC-OXIDE
   SYNTHESIS; BLOOD-PRESSURE; SUPPLEMENTATION PREVENTS; ADIPOSE-TISSUE;
   VASCULAR DYSFUNCTION; GLOBAL BURDEN
AB Cardiovascular-kidney-metabolic (CKM) syndrome has emerged as a major global public health concern, posing a substantial threat to human health. Early-life exposure to oxidative stress may heighten vulnerability to the developmental programming of adult diseases, encompassing various aspects of CKM syndrome. Conversely, the initiation of adverse programming processes can potentially be thwarted through early-life antioxidant interventions. Melatonin, originally recognized for its antioxidant properties, is an endogenous hormone with diverse biological functions. While melatonin has demonstrated benefits in addressing disorders linked to oxidative stress, there has been comparatively less focus on investigating its reprogramming effects on CKM syndrome. This review consolidates the current knowledge on the role of oxidative stress during pregnancy and lactation in inducing CKM traits in offspring, emphasizing the underlying mechanisms. The multifaceted role of melatonin in regulating oxidative stress, mediating fetal programming, and preventing adverse outcomes in offspring positions it as a promising reprogramming strategy. Currently, there is a lack of sufficient information in humans, and the available evidence primarily originates from animal studies. This opens up new avenues for novel preventive intervention in CKM syndrome.
C1 [Tain, You-Lin] Kaohsiung Chang Gung Mem Hosp, Div Pediat Nephrol, Kaohsiung 833, Taiwan.
   [Tain, You-Lin] Kaohsiung Chang Gung Mem Hosp, Inst Translat Res Biomed, Kaohsiung 833, Taiwan.
   [Tain, You-Lin] Chang Gung Univ, Coll Med, Taoyuan 333, Taiwan.
   [Hsu, Chien-Ning] Kaohsiung Chang Gung Mem Hosp, Dept Pharm, Kaohsiung 833, Taiwan.
   [Hsu, Chien-Ning] Kaohsiung Med Univ, Sch Pharm, Kaohsiung 807, Taiwan.
C3 Chang Gung Memorial Hospital; Chang Gung Memorial Hospital; Chang Gung
   University; Chang Gung Memorial Hospital; Kaohsiung Medical University
RP Hsu, CN (corresponding author), Kaohsiung Chang Gung Mem Hosp, Dept Pharm, Kaohsiung 833, Taiwan.; Hsu, CN (corresponding author), Kaohsiung Med Univ, Sch Pharm, Kaohsiung 807, Taiwan.
EM tainyl@cgmh.org.tw; cnhsu@cgmh.org.tw
RI Tain, You-Lin/H-2827-2019; Hsu, Chien-Ning/GLS-4014-2022
OI Tain, You-Lin/0000-0002-7059-6407; Hsu, Chien-Ning/0000-0001-7470-528X
FU Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan
FX No Statement Available
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PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD FEB
PY 2024
VL 13
IS 2
AR 226
DI 10.3390/antiox13020226
PG 18
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA IY7Z8
UT WOS:001169979600001
PM 38397824
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Ma, X
   Nan, F
   Liang, HT
   Shu, PY
   Fan, XZ
   Song, XS
   Hou, YF
   Zhang, DF
AF Ma, Xiao
   Nan, Fang
   Liang, Hantian
   Shu, Panyin
   Fan, Xinzou
   Song, Xiaoshuang
   Hou, Yanfeng
   Zhang, Dunfang
TI Excessive intake of sugar: An accomplice of inflammation
SO FRONTIERS IN IMMUNOLOGY
LA English
DT Review
DE macrophages; autoimmune disorders; Th17 cells (Th17); low-grade chronic
   inflammation; TGF-beta; IL-1beta
ID SWEETENED BEVERAGE CONSUMPTION; CORONARY-HEART-DISEASE; FRUCTOSE CORN
   SYRUP; METABOLIC SYNDROME; INSULIN SENSITIVITY; AUTOIMMUNE-DISEASES;
   LIPID-ACCUMULATION; SIGNALING PATHWAYS; OXIDATIVE STRESS; GUT MICROBIOTA
AB High sugar intake has long been recognized as a potential environmental risk factor for increased incidence of many non-communicable diseases, including obesity, cardiovascular disease, metabolic syndrome, and type 2 diabetes (T2D). Dietary sugars are mainly hexoses, including glucose, fructose, sucrose and High Fructose Corn Syrup (HFCS). These sugars are primarily absorbed in the gut as fructose and glucose. The consumption of high sugar beverages and processed foods has increased significantly over the past 30 years. Here, we summarize the effects of consuming high levels of dietary hexose on rheumatoid arthritis (RA), multiple sclerosis (MS), psoriasis, inflammatory bowel disease (IBD) and low-grade chronic inflammation. Based on these reported findings, we emphasize that dietary sugars and mixed processed foods may be a key factor leading to the occurrence and aggravation of inflammation. We concluded that by revealing the roles that excessive intake of hexose has on the regulation of human inflammatory diseases are fundamental questions that need to be solved urgently. Moreover, close attention should also be paid to the combination of high glucose-mediated immune imbalance and tumor development, and strive to make substantial contributions to reverse tumor immune escape.
C1 [Ma, Xiao; Nan, Fang; Liang, Hantian; Shu, Panyin; Fan, Xinzou; Song, Xiaoshuang; Zhang, Dunfang] Sichuan Univ, West China Hosp, Dept Biotherapy, State Key Lab Biotherapy, Chengdu, Peoples R China.
   [Ma, Xiao; Nan, Fang; Liang, Hantian; Shu, Panyin; Fan, Xinzou; Song, Xiaoshuang; Zhang, Dunfang] Sichuan Univ, West China Hosp, Canc Ctr, Chengdu, Peoples R China.
   [Hou, Yanfeng] Shandong First Med Univ, Affiliated Hosp 1, Dept Rheumatol & Autoimmunol, Jinan, Peoples R China.
   [Hou, Yanfeng] Shandong Provincial Qianfoshan Hosp, Shandong Key Lab Rheumat Dis & Translationalmedici, Shandong Med & Hlth Key Lab Rheumatism, Jinan, Peoples R China.
C3 Sichuan University; Sichuan University; Shandong First Medical
   University & Shandong Academy of Medical Sciences; Shandong First
   Medical University & Shandong Academy of Medical Sciences
RP Zhang, DF (corresponding author), Sichuan Univ, West China Hosp, Dept Biotherapy, State Key Lab Biotherapy, Chengdu, Peoples R China.; Zhang, DF (corresponding author), Sichuan Univ, West China Hosp, Canc Ctr, Chengdu, Peoples R China.; Hou, YF (corresponding author), Shandong First Med Univ, Affiliated Hosp 1, Dept Rheumatol & Autoimmunol, Jinan, Peoples R China.; Hou, YF (corresponding author), Shandong Provincial Qianfoshan Hosp, Shandong Key Lab Rheumat Dis & Translationalmedici, Shandong Med & Hlth Key Lab Rheumatism, Jinan, Peoples R China.
EM yfhou1016@163.com; izdf@163.com
RI song, xiaoshuang/GSN-4958-2022
OI Zhang, Dunfang/0000-0001-7545-9930
FU Key Project of the Science and Technology Department of Sichuan Province
   [2022YFH0100]; National Natural Science Foundation of China [82171829];
   1.3.5 Project for Disciplines of Excellence, West China Hospital,
   Sichuan University [ZYYC21012]; Fundamental Research Funds for the
   Central Universities [20822041E4084]; Shandong Medical and Health
   Technology Development Funds [2014WS0361]; Special Fund for Flow
   Cytometry Lymphocyte Subgroups of Shandong Provincial Medical
   Association [YXH2022ZX03223]
FX This work was supported by the Key Project of the Science and Technology
   Department of Sichuan Province (NO. 2022YFH0100), the National Natural
   Science Foundation of China (NO. 82171829), the 1.3.5 Project for
   Disciplines of Excellence, West China Hospital, Sichuan University (NO.
   ZYYC21012), the Fundamental Research Funds for the Central Universities
   (20822041E4084), Special Fund for Flow Cytometry Lymphocyte Subgroups of
   Shandong Provincial Medical Association (YXH2022ZX03223), and Shandong
   Medical and Health Technology Development Funds (2014WS0361).
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NR 123
TC 119
Z9 122
U1 17
U2 76
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-3224
J9 FRONT IMMUNOL
JI Front. Immunol.
PD AUG 31
PY 2022
VL 13
AR 988481
DI 10.3389/fimmu.2022.988481
PG 12
WC Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology
GA 4V5LG
UT WOS:000859517700001
PM 36119103
OA Green Published, gold
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Du, SS
   Sun, SH
   Liu, L
   Zhang, Q
   Guo, FC
   Li, CL
   Feng, RN
   Sun, CH
AF Du, Shanshan
   Sun, Shuhong
   Liu, Liyan
   Zhang, Qao
   Guo, Fuchuan
   Li, Chunlong
   Feng, Rennan
   Sun, Changhao
TI Effects of Histidine Supplementation on Global Serum and Urine
   <SUP>1</SUP>H NMR-based Metabolomics and Serum Amino Acid Profiles in
   Obese Women from a Randomized Controlled Study
SO JOURNAL OF PROTEOME RESEARCH
LA English
DT Article
DE histidine; H-1 nuclear magnetic resonance-based metabolomics; amino acid
   profile; obesity; metabolic syndrome
ID INSULIN-RESISTANCE; OXIDATIVE STRESS; METABOLISM; INFLAMMATION; LEUCINE;
   IDENTIFICATION; ASSOCIATION; BETAINE; MICE
AB The aim of current study was to investigate the metabolic changes associated with histidine supplementation in serum and urine metabolic signatures and serum amino acid (AA) profiles. Serum and urine H-1 NMR-based metabolomics and serum AA profiles were employed in 32 and 37 obese women with metabolic syndrome (MetS) intervened with placebo or histidine for 12 weeks. Multivariable statistical analysis were conducted to define characteristic metabolites. In serum H-1 NMR metabolic profiles, increases in histidine, glutamine, aspartate, glycine, choline, and trimethylamine-N-oxide (TMAO) were observed; meanwhile, decreases in cholesterol, triglycerides, fatty acids and unsaturated lipids, acetone, and alpha/beta-glucose were exhibited after histidine supplement. In urine H-1 NMR metabolic profiles, citrate, creatinine/creatine, methylguanidine, and betaine + TMAO were higher, while hippurate was lower in histidine supplement group. In serum AA profiles, 10 AAs changed after histidine supplementation, including increased histidine, glycine, alanine, lysine, asparagine, and tyrosine and decreased leucine, isoleucine, ornithine, and citrulline. The study showed a systemic metabolic response in serum and urine metabolomics and AA profiles to histidine supplementation, showing significantly changed metabolism in AAs, lipid, and glucose in obese women with MetS.
C1 [Du, Shanshan; Liu, Liyan; Zhang, Qao; Feng, Rennan; Sun, Changhao] Harbin Med Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, 157 Baojian Rd, Harbin 150086, Heilongjiang Pr, Peoples R China.
   [Sun, Shuhong] Harbin Med Univ, Affiliated Hosp 1, Dept Psychiat, 23 Youzheng St, Harbin 150001, Heilongjiang Pr, Peoples R China.
   [Guo, Fuchuan] Fujian Med Univ, Sch Publ Hlth, Dept Nutr & Food Safety, 1 Xuefu North Rd, Fuzhou 350122, Fujian Province, Peoples R China.
   [Li, Chunlong] Harbin Med Univ, Affiliated Hosp 2, Dept Gen Surg, 246 Xuefu Rd, Harbin 150086, Heilongjiang Pr, Peoples R China.
C3 Harbin Medical University; Harbin Medical University; Fujian Medical
   University; Harbin Medical University
RP Feng, RN; Sun, CH (corresponding author), Harbin Med Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, 157 Baojian Rd, Harbin 150086, Heilongjiang Pr, Peoples R China.
EM fengrennan@163.com; changhao2002sun@gmail.com
RI du, shanshan/AAE-7491-2022; Chunlong, Li/AAM-8644-2021
OI Guo, Fuchuan/0000-0003-2528-1278
FU National Natural Science Fund of China [81573133, 8202184, 81202185];
   Natural Science Fund of Heilongjiang Province [H2016018]
FX R.F. received funding from the National Natural Science Fund of China
   Nos. 81573133 and 8202184 and Natural Science Fund of Heilongjiang
   Province No. H2016018. F.G. received funding from the National Natural
   Science Fund of China No. 81202185.
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NR 53
TC 37
Z9 49
U1 1
U2 40
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1535-3893
EI 1535-3907
J9 J PROTEOME RES
JI J. Proteome Res.
PD JUN
PY 2017
VL 16
IS 6
BP 2221
EP 2230
DI 10.1021/acs.jproteome.7b00030
PG 10
WC Biochemical Research Methods
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA EW9PD
UT WOS:000402850800010
PM 28447460
DA 2025-06-11
ER

PT J
AU Takeda, Y
AF Takeda, Yoshiyu
TI Effects of eplerenone, a selective mineralocorticoid receptor
   antagonist, on clinical and experimental salt-sensitive hypertension
SO HYPERTENSION RESEARCH
LA English
DT Review
DE aldosterone; eplerenone; obese; renin; salt
ID ANGIOTENSIN-II; METABOLIC SYNDROME; ADRENAL-STEROIDS; CARDIAC FIBROSIS;
   BLOOD-PRESSURE; ALDOSTERONE; RATS; SPIRONOLACTONE; ELECTROLYTES;
   EXPRESSION
AB Mineralocorticoid receptors (MRs) are expressed in non-epithelial tissues, such as blood vessels, the heart and adipose tissue. The combined effects of aldosterone and insulin link the metabolic syndrome with hypertension and salt sensitivity. Eplerenone is the newly developed inhibitor of MRs that has significantly fewer adverse effects than similar doses of spironolactone. Eplerenone has been reported to have anti-hypertensive and protective effects on cardiovascular and renal injury in salt-sensitive hypertensive animal models, such as the Dahl salt-sensitive (DS) hypertensive rat and leptin receptor-deficient spontaneously hypertensive rat (SHR/cp). Eplerenone also increases nitric oxide bioavailability and improves impaired endothelial function by decreasing oxidative stress. Clinical studies support the concept that eplerenone is effective for the treatment of salt-sensitive hypertension as well as idiopathic hyperaldosteronism and does not have adverse anti-androgenic adverse effects. In Japan, eplerenone has been used clinically since 2007 for the treatment of hypertension, with its price being marginally lower than all types of angiotensin II receptor antagonists. This will inevitably result in an increasing number of hypertensive patients and those with primary aldosteronism being treated with this agent in the near future. Hypertension Research ( 2009) 32, 321-324; doi:10.1038/hr.2009.29; published online 20 March 2009
C1 Kanazawa Univ, Dept Internal Med, Grad Sch Med Sci, Kanazawa, Ishikawa 9208641, Japan.
C3 Kanazawa University
RP Takeda, Y (corresponding author), Kanazawa Univ, Dept Internal Med, Grad Sch Med Sci, 13-1 Takara Machi, Kanazawa, Ishikawa 9208641, Japan.
EM takeday@med.kanazawa.u.ac.jp
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NR 33
TC 25
Z9 25
U1 0
U2 6
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0916-9636
EI 1348-4214
J9 HYPERTENS RES
JI Hypertens. Res.
PD MAY
PY 2009
VL 32
IS 5
BP 321
EP 324
DI 10.1038/hr.2009.29
PG 4
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 443DG
UT WOS:000265889800001
PM 19300447
OA Bronze
DA 2025-06-11
ER

PT J
AU Caturano, A
   Acierno, C
   Nevola, R
   Pafundi, PC
   Galiero, R
   Rinaldi, L
   Salvatore, T
   Adinolfi, LE
   Sasso, FC
AF Caturano, Alfredo
   Acierno, Carlo
   Nevola, Riccardo
   Pafundi, Pia Clara
   Galiero, Raffaele
   Rinaldi, Luca
   Salvatore, Teresa
   Adinolfi, Luigi Elio
   Sasso, Ferdinando Carlo
TI Non-Alcoholic Fatty Liver Disease: From Pathogenesis to Clinical Impact
SO PROCESSES
LA English
DT Review
DE NAFLD; insulin resistance; metabolic syndrome; cytokines; CV risk
AB Non-Alcoholic Fatty Liver Disease (NAFLD) is caused by the accumulation of fat in over 5% of hepatocytes in the absence of alcohol consumption. NAFLD is considered the hepatic manifestation of metabolic syndrome (MS). Recently, an expert consensus suggested as more appropriate the term MAFLD (metabolic-associated fatty liver disease). Insulin resistance (IR) plays a key role in the development of NAFLD, as it causes an increase in hepatic lipogenesis and an inhibition of adipose tissue lipolysis. Beyond the imbalance of adipokine levels, the increase in the mass of visceral adipose tissue also determines an increase in free fatty acid (FFA) levels. In turn, an excess of FFA is able to determine IR through the inhibition of the post-receptor insulin signal. Adipocytes secrete chemokines, which are able to enroll macrophages inside the adipose tissue, responsible, in turn, for the increased levels of TNF-alpha. The latter, as well as resistin and other pro-inflammatory cytokines such as IL-6, enhances insulin resistance and correlates with endothelial dysfunction and an increased cardiovascular (CV) risk. In this review, the role of diet, intestinal microbiota, genetic and epigenetic factors, low-degree chronic systemic inflammation, mitochondrial dysfunction, and endoplasmic reticulum stress on NAFLD have been addressed. Finally, the clinical impact of NAFLD on cardiovascular and renal outcomes, and its direct link with type 2 diabetes have been discussed.
C1 [Caturano, Alfredo; Acierno, Carlo; Nevola, Riccardo; Pafundi, Pia Clara; Galiero, Raffaele; Rinaldi, Luca; Adinolfi, Luigi Elio; Sasso, Ferdinando Carlo] Univ Campania Luigi Vanvitelli, Dept Adv Med & Surg Sci, Piazza L Miraglia 2, I-80138 Naples, Italy.
   [Salvatore, Teresa] Univ Campania Luigi Vanvitelli, Dept Precis Med, Piazza L Miraglia 2, I-80138 Naples, Italy.
C3 Universita della Campania Vanvitelli; Universita della Campania
   Vanvitelli
RP Sasso, FC (corresponding author), Univ Campania Luigi Vanvitelli, Dept Adv Med & Surg Sci, Piazza L Miraglia 2, I-80138 Naples, Italy.
EM alfredo.caturano@virgilio.it; carlo894@gmail.com;
   riccardo.nevola@unicampania.it; piaclara.pafundi@unicampania.it;
   raffaele.galiero@unicampania.it; luca.rinaldi@unicampania.it;
   teresa.salvatore@unicampania.it; luigielio.adinolfi@unicampania.it;
   ferdinando.sasso@unicampania.it
RI Caturano, Alfredo/AAA-4014-2022; Nevola, Riccardo/AAC-6298-2020; Sasso,
   Ferdinando Carlo/AAE-5665-2019; Galiero, Raffaele/KTP-8361-2024; Nevola,
   Riccardo/G-3257-2018; Caturano, Alfredo/ACM-4169-2022; PAFUNDI, PIA
   CLARA/GLN-5679-2022
OI Nevola, Riccardo/0000-0003-3320-3878; ADINOLFI, Luigi
   Elio/0000-0001-8453-4912; Caturano, Alfredo/0000-0001-7761-7533;
   Rinaldi, Luca/0000-0002-6541-3821; Sasso, Ferdinando
   Carlo/0000-0002-9142-7848; Acierno, Carlo/0000-0002-1239-7012; PAFUNDI,
   PIA CLARA/0000-0002-0310-3529
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NR 185
TC 74
Z9 76
U1 1
U2 8
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2227-9717
J9 PROCESSES
JI Processes
PD JAN
PY 2021
VL 9
IS 1
AR 135
DI 10.3390/pr9010135
PG 18
WC Engineering, Chemical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering
GA PW5UD
UT WOS:000610734500001
OA gold
DA 2025-06-11
ER

PT J
AU Vidovic, B
   Dordevic, B
   Milovanovic, S
   Skrivanj, S
   Pavlovic, Z
   Stefanovic, A
   Kotur-Stevuljevic, J
AF Vidovic, Bojana
   Dordevic, Brizita
   Milovanovic, Srdan
   Skrivanj, Sandra
   Pavlovic, Zoran
   Stefanovic, Aleksandra
   Kotur-Stevuljevic, Jelena
TI Selenium, Zinc, and Copper Plasma Levels in Patients with Schizophrenia:
   Relationship with Metabolic Risk Factors
SO BIOLOGICAL TRACE ELEMENT RESEARCH
LA English
DT Article
DE Selenium; Copper; Zinc; Metabolic syndrome; Schizophrenia
ID OXIDATIVE STRESS; INSULIN-RESISTANCE; TRACE-ELEMENTS; SERUM COPPER;
   ANTIOXIDANTS; INFLAMMATION; HYPOTHESIS; MORTALITY; DIETARY; BLOOD
AB The aim of this study was to determine the plasma selenium (Se), copper (Cu), and zinc (Zn) levels and to evaluate their possible association with metabolic syndrome (MetS) components in patients with schizophrenia. The study group consisted of 60 patients with schizophrenia and 60 sex- and age-matched healthy controls. Anthropometric measurements, blood pressure, and biochemical analysis of fasting blood were performed in all subjects. Patients with schizophrenia had significantly higher plasma Cu concentrations compared with controls (0.97 +/- 0.31 vs. 0.77 +/- 0.32 mg/L, p = 0.001). The plasma Cu concentration showed a positive correlation with plasma glucose and diastolic blood pressure in the patient groups (r (s) = 0.263, p < 0.05 and r (s) = 0.272, p < 0.05, respectively). The plasma Se level correlated positive with MetS score (r (s) = 0.385, p < 0.01), waist circumference (r (s) = 0.344, p < 0.05), plasma glucose (r (s) = 0.319, p < 0.05), and triglyceride concentrations (r (s) = 0.462, p < 0.001) in patients with schizophrenia. Plasma Zn did not correlate with any of the MetS components. These results suggest that alterations in plasma Cu and Se levels in medicated patients with schizophrenia could be associated with metabolic risk factors.
C1 [Vidovic, Bojana; Dordevic, Brizita] Univ Belgrade, Dept Bromatol, Fac Pharm, Belgrade 11221, Serbia.
   [Milovanovic, Srdan] Univ Belgrade, Fac Med, Belgrade 11000, Serbia.
   [Milovanovic, Srdan] Clin Ctr Serbia, Psychiat Clin, Belgrade 11000, Serbia.
   [Skrivanj, Sandra] Univ Belgrade, Fac Chem, Belgrade 11000, Serbia.
   [Pavlovic, Zoran] Inst Publ Hlth Pozarevac, Pozarevac 12000, Serbia.
   [Stefanovic, Aleksandra; Kotur-Stevuljevic, Jelena] Univ Belgrade, Dept Med Biochem, Fac Pharm, Belgrade 11221, Serbia.
C3 University of Belgrade; University of Belgrade; Clinical Centre of
   Serbia; University of Belgrade; University of Belgrade
RP Vidovic, B (corresponding author), Univ Belgrade, Dept Bromatol, Fac Pharm, Vojvode Stepe 450, Belgrade 11221, Serbia.
EM bojana@pharmacy.bg.ac.rs
RI Djordjevic, Brizita/V-5590-2017; Vidovic, Bojana/S-2370-2017
OI Milovanovic, Srdjan/0000-0003-2516-0783; Vidovic,
   Bojana/0000-0001-6644-6230; Stefanovic, Aleksandra/0000-0002-0331-6807
FU Ministry of Education, Science and Technological Development, Republic
   of Serbia [III46001]
FX We appreciate the financial support from the Ministry of Education,
   Science and Technological Development, Republic of Serbia (project
   number III46001). The authors would like to thank Dr. Steve Quarrie for
   his help in editing the manuscript.
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NR 46
TC 57
Z9 59
U1 0
U2 11
PU HUMANA PRESS INC
PI TOTOWA
PA 999 RIVERVIEW DRIVE SUITE 208, TOTOWA, NJ 07512 USA
SN 0163-4984
EI 1559-0720
J9 BIOL TRACE ELEM RES
JI Biol. Trace Elem. Res.
PD DEC
PY 2013
VL 156
IS 1-3
BP 22
EP 28
DI 10.1007/s12011-013-9842-1
PG 7
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 264RJ
UT WOS:000327897800004
PM 24150923
DA 2025-06-11
ER

PT J
AU Meng, R
   Zhu, DL
   Bi, Y
   Yang, DH
   Wang, YP
AF Meng, Ran
   Zhu, Da-Long
   Bi, Yan
   Yang, Dong-Hui
   Wang, Ya-Ping
TI Anti-Oxidative Effect of Apocynin on Insulin Resistance in High-Fat Diet
   Mice
SO ANNALS OF CLINICAL AND LABORATORY SCIENCE
LA English
DT Article
DE apocynin; oxidative stress; insulin resistance; high-fat diet
ID NADPH OXIDASE ACTIVATION; OXIDATIVE STRESS; METABOLIC SYNDROME;
   LIQUID-CHROMATOGRAPHY; HEMORRHAGIC-SHOCK; MOUSE MODELS; LIVER-INJURY;
   RATS; INFLAMMATION; HYPERCHOLESTEROLEMIA
AB The present study examines the effects of apocynin on oxidative stress and antioxidant enzymes in high-fat diet (HFD) induced obese mice. After 12 weeks on HFD, the C57BL/6J mice that clearly exhibited insulin resistance received apocynin (2.4g/L) in their drinking water for five weeks. The results show that apocynin treatment significantly ameliorated hyperglycemia, hyperinsulinemia and dyslipidemia in HFD mice.Furthermore, the intraperitoneal glucose tolerance test (IPGTT) and homeostasis model assessment of insulin resistance (HOMA-IR) indicate significant improvement of insulin sensitivity in HFD mice after apocynin treatment. Compared to the HFD control mice, serum malondialdehyde (MDA) was significantly lower and serum superoxide dismutase (SOD) was significantly higher in apocynin treated HFD mice, indicating that apocynin suppressed systemic oxidative stress in the treated group. In the liver, apocynin significantly reduced the level of MDA. Accordingly, apocynin treatment strengthened the antioxidative defense system with an increased activity of SOD, glutathione-peroxidase (GSHpx) and content of reduced glutathione (GSH). We also found that hepatic catalase (CAT) activity significantly decreased after apocynin treatment which may indicate that apocynin reduces hydrogen peroxide and oxidative stress in the liver. These results suggest that apocynin may ameliorate insulin resistance by reducing systemic and hepatic oxidative stress in HFD fed mice.
C1 [Meng, Ran; Zhu, Da-Long; Bi, Yan; Yang, Dong-Hui] Nanjing Univ, Sch Med, Nanjing Drum Tower Hosp, Dept Endocrinol, Nanjing 210008, Peoples R China.
   [Meng, Ran; Wang, Ya-Ping] Nanjing Univ, Sch Med, Dept Med Genet, Nanjing 210093, Peoples R China.
   [Meng, Ran; Wang, Ya-Ping] Nanjing Univ, Jiangsu Key Lab Mol Med, Nanjing 210008, Peoples R China.
C3 Nanjing University; Nanjing University; Nanjing University
RP Zhu, DL (corresponding author), Nanjing Univ, Sch Med, Nanjing Drum Tower Hosp, Dept Endocrinol, 321 Zhongshan Rd, Nanjing 210008, Peoples R China.
EM zhudldr@gmail.com; wangyap@nju.edu.cn
RI Bi, Yan/O-5153-2015
FU National Natural Science Foundation of China [30671004, 81070273];
   Natural Science Foundation of Jiangsu Province of China [BS2006006]
FX This study was supported by National Natural Science Foundation of China
   (30671004, 81070273) and Natural Science Foundation of Jiangsu Province
   of China (BS2006006).
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NR 41
TC 38
Z9 42
U1 1
U2 16
PU ASSOC CLINICAL SCIENTISTS
PI MIDDLEBURY
PA PO BOX 1287, MIDDLEBURY, VT 05753 USA
SN 0091-7370
EI 1550-8080
J9 ANN CLIN LAB SCI
JI Ann. Clin. Lab. Sci.
PD SUM
PY 2011
VL 41
IS 3
BP 236
EP 243
PG 8
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA 837CH
UT WOS:000296168200005
PM 22075506
DA 2025-06-11
ER

PT J
AU García-Díaz, DF
   Campion, J
   Milagro, FI
   Lomba, A
   Marzo, F
   Martínez, JA
AF Garcia-Diaz, D. F.
   Campion, J.
   Milagro, F. I.
   Lomba, A.
   Marzo, F.
   Martinez, J. A.
TI Chronic mild stress induces variations in locomotive behavior and
   metabolic rates in high fat fed rats
SO JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
LA English
DT Article
DE obesity; stress; cafeteria diet; locomotive activity; calorimetry
ID BODY-WEIGHT; INSULIN-RESISTANCE; INDUCED OBESITY; ADIPOSE-TISSUE; DIET;
   HYPERTHERMIA; EXPRESSION; LEPTIN; MUSCLE; CELLS
AB Chronic mild stress (CMS) has been often associated to the pathogenesis of many diseases including obesity. Indeed, visceral obesity has been linked to the development of metabolic syndrome features and constitutes a serious risk factor for cardiovascular diseases and diabetes. In order to study possible mechanistic relationships between stress and the onset of obesity, we developed during 11 weeks a model of high-fat dietary intake (cafeteria diet) together with a CMS regimen in male Wistar rats. During the experimental period, basal metabolism by indirect calorimetry, rectal temperature, food intake, and locomotive markers were specifically analyzed. After 77 days, animals were sacrificed and body, adiposity and plasma biochemical profiles were also examined. As expected, cafeteria diet in unstressed animals induced a significative increase in body weight, adiposity, and insulin resistance markers. Locomotive variables, specifically distance, rearing and meander, were significantly increased by CMS on the first weeks of stress. Moreover, this model of CMS in Wistar rats increased significantly energy expenditure, and apparently interplayed with the dietary treatment on the muscle weight/fat weight ratio. In summary, this chronic stress model did not affected weight gain in control and high fat fed animals, but induced an interaction concerning the metabolic muscle/fat repartitioning.
C1 [Garcia-Diaz, D. F.; Campion, J.; Milagro, F. I.; Lomba, A.; Martinez, J. A.] Univ Navarra, Dept Nutr Food Sci Physiol & Toxicol, E-31080 Pamplona, Spain.
   [Marzo, F.] Univ Publ Navarra, Sch Agron, Lab Anim Physiol & Nutr, Pamplona, Spain.
C3 University of Navarra; Universidad Publica de Navarra
RP Martínez, JA (corresponding author), Univ Navarra, Dept Nutr Food Sci Physiol & Toxicol, E-31080 Pamplona, Spain.
EM jalfmtz@unav.cs
RI Marzo, Florencio/I-2611-2015; Milagro, Fermin/F-2315-2015; Garcia,
   Diego/AGH-4056-2022; Martinez Hernandez, J Alfredo/K-8709-2014
OI Garcia-Diaz, Diego/0000-0002-7551-0553; Martinez Hernandez, J
   Alfredo/0000-0001-5218-6941; Milagro, Fermin I./0000-0002-3228-9916;
   Campion, Javier/0000-0002-6522-8271
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NR 45
TC 43
Z9 44
U1 0
U2 10
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1138-7548
EI 1877-8755
J9 J PHYSIOL BIOCHEM
JI J. Physiol. Biochem.
PD DEC
PY 2007
VL 63
IS 4
BP 337
EP 346
DI 10.1007/BF03165765
PG 10
WC Biochemistry & Molecular Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Physiology
GA 279JG
UT WOS:000254350900006
PM 18457009
DA 2025-06-11
ER

PT J
AU Albardan, L
   Platat, C
   Kalupahana, NS
AF Albardan, Laila
   Platat, Carine
   Kalupahana, Nishan Sudheera
TI Role of Omega-3 Fatty Acids in Improving Metabolic Dysfunctions in
   Polycystic Ovary Syndrome
SO NUTRIENTS
LA English
DT Review
DE polycystic ovary syndrome; omega-3 fatty acids; metabolic syndrome
ID POLYUNSATURATED FATTY-ACIDS; INSULIN-RESISTANCE; OXIDATIVE STRESS;
   RISK-FACTORS; ARACHIDONIC-ACID; LIPID PROFILES; DASH DIET; WOMEN;
   SUPPLEMENTATION; N-3
AB Polycystic ovary syndrome (PCOS) is a common endocrine disorder that impacts women of reproductive age. In addition to reproductive and psychological complications, women with PCOS are also at a higher risk of developing metabolic diseases such as obesity, type 2 diabetes and cardiovascular disease. While weight reduction can help manage these complications in overweight or obese women, many weight loss interventions have been ineffective due to weight stigma and its psychological impact on women with PCOS. Therefore, exploring alternative dietary strategies which do not focus on weight loss per se is of importance. In this regard, omega-3 polyunsaturated fatty acids of marine origin (n-3 PUFAs), which are known for their hypotriglyceridemic, cardioprotective and anti-inflammatory effects, have emerged as a potential therapy for prevention and reversal of metabolic complications in PCOS. Several clinical trials showed that n-3 PUFAs can improve components of metabolic syndrome in women with PCOS. In this review, we first summarize the available clinical evidence for different dietary patterns in improving PCOS complications. Next, we summarize the clinical evidence for n-3 PUFAs for alleviating metabolic complications in PCOS. Finally, we explore the mechanisms by which n-3 PUFAs improve the metabolic disorders in PCOS in depth.
C1 [Albardan, Laila; Platat, Carine; Kalupahana, Nishan Sudheera] United Arab Emirates Univ, Coll Med & Hlth Sci, Dept Nutr & Hlth, POB 15551, Al Ain, U Arab Emirates.
C3 United Arab Emirates University
RP Kalupahana, NS (corresponding author), United Arab Emirates Univ, Coll Med & Hlth Sci, Dept Nutr & Hlth, POB 15551, Al Ain, U Arab Emirates.
EM nkalupahana@uaeu.ac.ae
RI Kalupahana, Nishan/E-1913-2011
OI PLATAT, Carine/0000-0002-8704-6372; Albardan, Laila/0000-0001-9880-440X;
   Kalupahana, Nishan/0000-0001-7129-5588
FU United Arab Emirates University [G00004624]
FX This research was funded by United Arab Emirates University, research
   start-up grant (G00004624)-N.S.K.
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NR 94
TC 5
Z9 5
U1 5
U2 8
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD SEP
PY 2024
VL 16
IS 17
AR 2961
DI 10.3390/nu16172961
PG 16
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA F6N3I
UT WOS:001310961600001
PM 39275277
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Borowska, B
   Suder, A
   Klis, K
   Wronka, I
AF Borowska, Beata
   Suder, Agnieszka
   Klis, Katarzyna
   Wronka, Iwona
TI Associations between Sleep Duration and Anthropometric Indices of
   Adiposity in Female University Students
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Article
DE anthropologic indices; sleep duration; BMI
ID WEIGHT-GAIN; INCREASED RISK; OBESITY; ADULTS; QUALITY; RHYTHM; POOR; AGE
AB Objectives: To examine associations between sleep duration as well as time of going to sleep and anthropometric indices related to the amount and distribution of adiposity. Material: A total of 969 female university students, aged 19-24 years. Methods: Participants self-reported their sleep duration. Body weight, height, and waist circumference were measured. BMI, WHR and WHtR were calculated. Statistical analyses of results involved logistic regression models. Socioeconomic status and level of stress were added as covariates. Results: In 15% of the sample, sleep was too short (<6 h), and 10% slept too long (>8 h). Compared to women who followed the recommended sleep duration, among short sleepers, both underweight and overweight were more frequent, while long sleepers were more likely to be overweight. A higher prevalence of abdominal obesity and increased risk of metabolic syndrome were observed in both short and long sleepers than in recommended sleepers. Irregular sleep times were connected with higher OR, both for BMI < 18.5 and BMI > 25, for WC > 80, and WHtR below 0.4 and above 0.5. Irregular sleep times also led to an increased risk of metabolic diseases prevalence. Conclusions: Both too long and too short sleep increases the risk of overweight, obesity and abdominal obesity and, as a consequence, the risk of metabolic syndrome in young women.
C1 [Borowska, Beata] Univ Lodz, Fac Biol & Environm Protect, Dept Anthropol, PL-90136 Lodz, Poland.
   [Suder, Agnieszka] Univ Phys Educ, Dept Anat, PL-31571 Krakow, Poland.
   [Klis, Katarzyna] Univ Wroclaw, Dept Human Biol, PL-50137 Wroclaw, Poland.
   [Wronka, Iwona] Jagiellonian Univ, Fac Biol, Inst Zool & Biomed Res, Lab Anthropol, PL-31007 Krakow, Poland.
C3 University of Lodz; University of Wroclaw; Jagiellonian University
RP Borowska, B (corresponding author), Univ Lodz, Fac Biol & Environm Protect, Dept Anthropol, PL-90136 Lodz, Poland.
EM beata.borowska@biol.uni.lodz.pl
RI Borowska, Beata/ABR-9957-2022; Suder, Agnieszka/GZA-5397-2022
OI Borowska, Beata/0000-0001-6449-6955; Wronka, Iwona/0000-0002-8740-7991;
   Suder, Agnieszka/0000-0001-6135-8274
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   WORLD REP DIS
NR 48
TC 7
Z9 7
U1 0
U2 10
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD SEP
PY 2022
VL 19
IS 18
AR 11681
DI 10.3390/ijerph191811681
PG 9
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA 4T6LN
UT WOS:000858226200001
PM 36141950
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU dos Santos, M
   Veronese, FV
   Moresco, RN
AF dos Santos, Mariane
   Veronese, Francisco Verissimo
   Moresco, Rafael Noal
TI Uric acid and kidney damage in systemic lupus erythematosus
SO CLINICA CHIMICA ACTA
LA English
DT Review
DE Systemic lupus erythematosus; Lupus nephritis; Uric acid
ID B SIGNALING PATHWAY; INFLAMMATORY BIOMARKERS; OXIDATIVE STRESS;
   NEPHRITIS; DISEASE; HYPERURICEMIA; CLASSIFICATION; PATHOGENESIS;
   MANAGEMENT; PROGRESSION
AB Systemic lupus erythematosus (SLE) is an autoimmune disease that affects multiple organs; lupus nephritis (LN) is one of the most severe complications of SLE. In the kidneys, an intense inflammatory reaction affects the glomeruli and tubular interstitium.
   Uric acid has been considered a key molecule in the pathogenesis of some conditions such as metabolic syndrome, hypertension, and kidney disease as it is produced by injured cells and promotes immune-inflammatory responses. In this regard, high serum uric acid concentrations may be involved in the activation of some inflammatory pathways, associated with kidney damage in SLE. Therefore, the purpose of this article was to review the main physiological mechanisms and clinical data on the association between serum uric acid and kidney damage in SLE. Scientific evidence indicates that hyperuricemia has the potential to be an adjuvant in the development and progression of kidney manifestations in SLE. Uric acid may promote the activation of inflammatory pathways and the formation and deposition of autoantibodies in kidneys, leading to a reduction of glomerular filtration rate. Other potential mechanisms of this association include the presence of polymorphisms in the urate transporters, metabolic syndrome, use of some medications, and other situations associated with a reduced renal excretion of uric acid.
C1 [dos Santos, Mariane; Moresco, Rafael Noal] Univ Fed Santa Maria, Dept Clin & Toxicol Anal, Lab Clin Biochem, Santa Maria, RS, Brazil.
   [dos Santos, Mariane; Moresco, Rafael Noal] Univ Fed Santa Maria, Grad Program Pharmaceut Sci, Santa Maria, RS, Brazil.
   [Veronese, Francisco Verissimo] Hosp Clin Porto Alegre, Div Nephrol, Porto Alegre, RS, Brazil.
C3 Universidade Federal de Santa Maria (UFSM); Universidade Federal de
   Santa Maria (UFSM); Hospital de Clinicas de Porto Alegre
RP Moresco, RN (corresponding author), Univ Fed Santa Maria, Ctr Ciencias Saude, Dept Anal Clin & Toxicol, Ave Roraima 1000,Predio 26,Sala 1401, BR-97105900 Santa Maria, RS, Brazil.
EM rnmoresco@ufsm.br
RI ; Moresco, Rafael/K-6118-2017
OI dos Santos, Mariane/0000-0001-6273-1317; Moresco,
   Rafael/0000-0003-3072-5080
FU Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES,
   Brazil) [001]; Conselho Nacional de Desenvolvimento Cientifico e
   Tecnologico (CNPq, Brazil) [309799/2017-1]
FX M. Santos is recipient of a postdoctoral fellowship from the Coordenacao
   de Aperfeicoamento de Pessoal de Nivel Superior (CAPES, Brazil, finance
   code 001). R. N. Moresco is recipient of a research productivity
   scholarship from the Conselho Nacional de Desenvolvimento Cientifico e
   Tecnologico (CNPq, Brazil, number 309799/2017-1).
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NR 96
TC 29
Z9 29
U1 2
U2 31
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0009-8981
EI 1873-3492
J9 CLIN CHIM ACTA
JI Clin. Chim. Acta
PD SEP
PY 2020
VL 508
BP 197
EP 205
DI 10.1016/j.cca.2020.05.034
PG 9
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA ML1IJ
UT WOS:000549228300029
PM 32428504
DA 2025-06-11
ER

PT J
AU Sihali-Beloui, O
   El-Aoufi, S
   Maouche, B
   Marco, S
AF Sihali-Beloui, Ouahiba
   El-Aoufi, Salima
   Maouche, Boubekeur
   Marco, Sergio
TI Psammomys obesus, a unique model of metabolic syndrome,
   inflammation and autophagy in the pathologic development of hepatic
   steatosis
SO COMPTES RENDUS BIOLOGIES
LA English
DT Article
DE Psammomys obesus; Liver; Electron microscopy; Inflammation; Autophagy
ID FATTY LIVER-DISEASE; ENDOPLASMIC-RETICULUM STRESS; DIABETES-MELLITUS;
   SAND RAT; ADHESION MOLECULES; LIPID-METABOLISM; OBESITY; EXPRESSION;
   CYTOKINES; PROTEINS
AB The aim of our transmission electron microscope study was to show, for the first time, the alteration of liver cells involved in the evolution of steatosis to steatohepatitis on a murine model of the diet-induced metabolic syndrome, Psammomys obesus. This pathologic evolution was induced by using the standard laboratory diet during 10 months, and analyzed with metabolic studies and the immunohistochemistry technique. Four months later, hepatocytes charged with lipid vacuoles were involved in autophagy. Furthermore, in the sinusoids, we observed Kupffer cells, neutrophils and macrophages. All those cells were associated with necrotic hepatocytes inducing hepatocellular necrosis. We also noticed a synthesis of extracellular matrix in excess, caused by proliferation and activation of hepatic stellate cells in necrotic areas. We observed as well a fragmentation of the endoplasmic reticulum, which formed isolated membranes (phagophores) surrounding mitochondria. The complex membrane-mitochondria formed like an autophagosome. Thus, a defect in autophagy favored the development and progression of steatohepatitis. In conclusion, our results suggest that P. obesus is very well adapted for experimental research, and could help improve the early therapeutic management of patients and the prevention of autophagic risks in the liver. (C) 2016 Academie des sciences. Published by Elsevier Masson SAS. All rights reserved.
C1 [Sihali-Beloui, Ouahiba; El-Aoufi, Salima] Univ Sci & Technol Houari Boumediene, Fac Biol Sci, Lab Biol & Physiol Organisms Mol Modelling Endoth, POB 32, Dar El Beida 16111, Alger, Algeria.
   [Maouche, Boubekeur] USTHB, Fac Chem, Lab Theoret Phys Chem & Informat Chem, Dar El Beida 16111, Alger, Algeria.
   [Marco, Sergio] Inst Curie, Ctr Rech, F-91405 Orsay, France.
   [Marco, Sergio] INSERM, U1196, F-91405 Orsay, France.
   [Marco, Sergio] CNRS, UMR9187, F-91405 Orsay, France.
   [Marco, Sergio] Univ Paris Sud, Univ Paris Saclay, F-91190 Gif Sur Yvette, France.
C3 University Science & Technology Houari Boumediene; University Science &
   Technology Houari Boumediene; UNICANCER; Universite PSL; Institut Curie;
   Institut National de la Sante et de la Recherche Medicale (Inserm);
   Universite Paris Saclay; Centre National de la Recherche Scientifique
   (CNRS); CNRS - Institute of Chemistry (INC); Universite Paris Saclay;
   Universite Paris Saclay
RP Sihali-Beloui, O (corresponding author), Univ Sci & Technol Houari Boumediene, Fac Biol Sci, Lab Biol & Physiol Organisms Mol Modelling Endoth, POB 32, Dar El Beida 16111, Alger, Algeria.
EM obeloui@yahoo.fr
RI marco, SERGIO/E-4875-2017
FU General Direction of Scientific Research and Development of Technology
   (Ministry of Higher Education and Scientific Research, DGRSDT-MESRS),
   Algeria
FX This research is supported by the General Direction of Scientific
   Research and Development of Technology (Ministry of Higher Education and
   Scientific Research, DGRSDT-MESRS), Algeria.
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NR 54
TC 7
Z9 7
U1 0
U2 12
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI PARIS
PA 23 RUE LINOIS, 75724 PARIS, FRANCE
SN 1631-0691
EI 1768-3238
J9 CR BIOL
JI C. R. Biol.
PD NOV-DEC
PY 2016
VL 339
IS 11-12
BP 475
EP 486
DI 10.1016/j.crvi.2016.08.001
PG 12
WC Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics
GA EB5SS
UT WOS:000387441300005
PM 27614586
OA Bronze
DA 2025-06-11
ER

PT J
AU Terruzzi, I
   Senesi, P
AF Terruzzi, Ileana
   Senesi, Pamela
TI Does intestinal dysbiosis contribute to an aberrant inflammatory
   response to severe acute respiratory syndrome coronavirus 2 in frail
   patients?
SO NUTRITION
LA English
DT Review
DE SARS-CoV-2; COVID-19; metabolic syndrome; cardiovascular diseases; gut
   dysbiosis; nutraceuticals
ID TRIMETHYLAMINE-N-OXIDE; NLRP3 INFLAMMASOME; GUT MICROBIOTA; CUTTING
   EDGE; ENDOTHELIAL DYSFUNCTION; OXIDATIVE STRESS; ANGIOTENSIN-II;
   ACTIVATION; TLR4; LIPOPOLYSACCHARIDE
AB In a few months, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has become the main health problem worldwide. Epidemiologic studies revealed that populations have different vulnerabilities to SARS-CoV-2. Severe outcomes of the coronavirus disease 2019 (COVID-19) with an increased risk of death are observed in patients with metabolic syndrome, as well as diabetic and heart conditions (frail population). Excessive proinflammatory cytokine storm could be the main cause of increased vulnerability in this frail population. In patients with diabetes and/or heart disease, a low inflammatory state is often associated with gut dysbiosis. The increase amount of microbial metabolites (i.e., trimethylamine N-oxide and lipopolysaccharide), which generate an inflammatory microenvironment, is probably associated with an improved risk of severe illness from COVID-19. Nutritional interventions aimed at restoring the gut microbial balance could represent preventive strategies to protect the frail population from COVID-19. This narrative review presents the possible molecular mechanisms by which intestinal dysbiosis that enhances the inflammatory state could promote the spread of SARS-CoV-2 infection. Some nutritional strategies to counteract inflammation in frail patients are also analyzed. (C) 2020 Elsevier Inc. All rights reserved.
C1 [Terruzzi, Ileana; Senesi, Pamela] Univ Milan, Dept Biomed Sci & Hlth, Milan, Italy.
   [Terruzzi, Ileana; Senesi, Pamela] IRCCS MultiMed, Dept Endocrinol Nutr & Metab Dis, Milan, Italy.
C3 University of Milan; IRCCS Multimedica
RP Terruzzi, I (corresponding author), Univ Milan, Dept Biomed Sci & Hlth, Milan, Italy.; Terruzzi, I (corresponding author), IRCCS MultiMed, Dept Endocrinol Nutr & Metab Dis, Milan, Italy.
EM ileana.terruzzi@unimi.it
RI Senesi, Pamela/AAA-5678-2019; Terruzzi, Ileana/AAA-9737-2019
OI Terruzzi, Ileana/0000-0002-8663-4033
FU Italian Ministry of Health-Ricerca Corrente-IRCCS Multimedica
FX This work was supported by the Italian Ministry of Health-Ricerca
   Corrente-IRCCS Multimedica.
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NR 91
TC 17
Z9 18
U1 0
U2 9
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0899-9007
EI 1873-1244
J9 NUTRITION
JI Nutrition
PD NOV-DEC
PY 2020
VL 79-80
AR 110996
DI 10.1016/j.nut.2020.110996
PG 6
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA PY7HH
UT WOS:000612212200028
PM 33002653
OA Green Published
DA 2025-06-11
ER

PT J
AU Garg, R
   Adler, GK
AF Garg, Rajesh
   Adler, Gail K.
TI Role of mineralocorticoid receptor in insulin resistance
SO CURRENT OPINION IN ENDOCRINOLOGY DIABETES AND OBESITY
LA English
DT Review
DE aldosterone; insulin resistance; mineralocorticoid receptor; obesity
ID PLASMA-RENIN ACTIVITY; HUMAN PROMONOCYTIC CELLS; BODY-MASS INDEX;
   BLOOD-PRESSURE; ESSENTIAL-HYPERTENSION; PRIMARY ALDOSTERONISM; METABOLIC
   SYNDROME; WEIGHT-LOSS; RISK-FACTORS; PROINFLAMMATORY ADIPOKINES
AB Purpose of review
   Recent data suggest that mineralocorticoid receptor activation can affect insulin resistance independent of its effects on blood pressure. This review discusses new evidence linking mineralocorticoid receptor to insulin resistance and the underlying mechanisms of these effects.
   Recent findings
   Observational studies have shown mineralocorticoid activity to be associated with insulin resistance irrespective of race, blood pressure or body weight. Increased mineralocorticoid activity may be the common link between obesity, hypertension, dyslipidemia and insulin resistance, features that make up the metabolic syndrome. Treatment of primary aldosteronism is associated with a decrease in insulin resistance and provides one of the most convincing evidences in favor of the contribution of mineralocorticoid receptor to insulin resistance. Dietary salt restriction, which increases aldosterone levels, is also associated with an increase in insulin resistance. Potential mechanisms by which mineralocorticoid receptor may contribute to insulin resistance include a decreased transcription of the insulin receptor gene, increased degradation of insulin receptor substrates, interference with insulin signaling mechanisms, decreased adiponectin production and increased oxidative stress and inflammation. Advantages of mineralocorticoid receptor antagonists on insulin resistance have been demonstrated in animal models.
   Summary
   There may be a benefit of mineralocorticoid receptor antagonists in human insulin resistance states, but more clinical research is needed to explore these possibilities.
C1 [Garg, Rajesh; Adler, Gail K.] Harvard Univ, Brigham & Womens Hosp, Sch Med, Div Endocrinol Diabet & Hypertens,Dept Med, Boston, MA 02115 USA.
C3 Harvard University; Harvard University Medical Affiliates; Brigham &
   Women's Hospital; Harvard Medical School
RP Adler, GK (corresponding author), Div Endocrinol Diabet & Hypertens, 221 Longwood Ave, Boston, MA 02115 USA.
EM gadler@partners.org
OI Garg, Rajesh/0000-0002-7779-1619; Adler, Gail/0000-0003-3506-7347
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NR 78
TC 24
Z9 25
U1 1
U2 17
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1752-296X
EI 1752-2978
J9 CURR OPIN ENDOCRINOL
JI Curr. Opin. Endocrinol. Diabetes Obes.
PD JUN
PY 2012
VL 19
IS 3
BP 168
EP 175
DI 10.1097/MED.0b013e3283533955
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 931YS
UT WOS:000303255900004
PM 22499218
DA 2025-06-11
ER

PT J
AU Tang, HX
   Zhang, X
   Huang, JT
   Luo, N
   Chen, HY
   Yang, QL
   Lin, HY
   Hua, H
AF Tang, Haoxian
   Zhang, Xuan
   Huang, Jingtao
   Luo, Nan
   Chen, Hongyu
   Yang, Qinglong
   Lin, Hanyuan
   Hua, Hao
TI Phthalate and gallstones: the mediation of insulin
SO FRONTIERS IN PUBLIC HEALTH
LA English
DT Article
DE plasticizer; cholelithiasis; hyperinsulinemia; mediation; NHANES
ID NUTRITION EXAMINATION SURVEY; METABOLIC SYNDROME; NATIONAL-HEALTH;
   ASSOCIATION; RESISTANCE; GLUCOSE; CHOLELITHIASIS; EXPOSURE; DISEASES
AB Background Exposure to a mixture of environmental chemicals may cause gallstone, but the evidence remains equivocal. The current study aims to investigate the association between phthalate metabolites and gallstones, and to explore their mediators.Methods Data from the National Health and Nutrition Examination Survey 2017-2018 on U.S. adults (>= 20 years) were analyzed to explore the association between phthalate metabolites and gallstones by employed survey-weighted logistic regression, restricted cubic spline (RCS), weighted quantile sum (WQS) regression, and Bayesian kernel machine regression (BKMR). Mediation analyses examined the role of oxidative stress markers, inflammatory markers, metabolic syndrome, body composition, diabetes, and insulin.Results The current study included 1,384 participants, representing 200.6 million U.S. adults. Our results indicated a significant association between phthalate metabolites, particularly high molecular weight metabolites such as Di(2-ethylhexyl) phthalate (DEHP) and 1,2-Cyclohexane dicarboxylic acid diisononyl ester (DINCH), and gallstones. Furthermore, mediation analyses indicated that phthalate metabolites may play a role in the development of gallstones by influencing insulin secretion. Subgroup analyses did not reveal significant interaction.Conclusion The association between exposure to phthalates and the occurrence of gallstones, potentially mediated by hyperinsulinemia from a nationally representative epidemiological perspective. These insights contribute to a better understanding of the potential health implications of plasticizers, emphasizing the need for proactive management measures.
C1 [Tang, Haoxian; Zhang, Xuan; Huang, Jingtao; Luo, Nan; Chen, Hongyu; Yang, Qinglong; Lin, Hanyuan] Shantou Univ, Med Coll, Shantou, Guangdong, Peoples R China.
   [Tang, Haoxian; Chen, Hongyu] Shantou Univ, Affiliated Hosp 1, Dept Cardiol, Med Coll, Shantou, Guangdong, Peoples R China.
   [Zhang, Xuan] Peking Univ, Shenzhen Hosp, Dept Bone & Joint Surg, Shenzhen, Guangdong, Peoples R China.
   [Huang, Jingtao] Peking Univ, Shenzhen Hosp, Dept Sports Med & Rehabil, Shenzhen, Guangdong, Peoples R China.
   [Luo, Nan] Shantou Univ Mental Hlth Ctr, Dept Psychiat, Shantou, Guangdong, Peoples R China.
   [Yang, Qinglong; Lin, Hanyuan] Shantou Univ, Dept Urol, Affiliated Hosp 2, Med Coll, Shantou, Guangdong, Peoples R China.
   [Hua, Hao] Guizhou Med Univ, Dept Hepat Biliary Pancreat Surg, Affiliate Hosp, Guiyang, Guizhou, Peoples R China.
C3 Shantou University; Shantou University; Peking University; Peking
   University; Shantou University; Guizhou Medical University
RP Hua, H (corresponding author), Guizhou Med Univ, Dept Hepat Biliary Pancreat Surg, Affiliate Hosp, Guiyang, Guizhou, Peoples R China.
EM a52906522222@163.com
RI Hongyu, Chen/ABZ-9662-2022; Tang, Haoxian/IAQ-6364-2023
OI Tang, Haoxian/0000-0002-4346-7159; Huang, Jingtao/0000-0003-4104-2402
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NR 60
TC 4
Z9 4
U1 1
U2 7
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 2296-2565
J9 FRONT PUBLIC HEALTH
JI Front. Public Health
PD JUN 5
PY 2024
VL 12
AR 1401420
DI 10.3389/fpubh.2024.1401420
PG 14
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA UQ5J7
UT WOS:001249534100001
PM 38903577
OA gold
DA 2025-06-11
ER

PT J
AU Lu, S
   Li, YR
   Qian, ZJ
   Zhao, TS
   Feng, ZW
   Weng, XG
   Yu, LL
AF Lu, Shen
   Li, Yanrong
   Qian, Zhaojun
   Zhao, Tiesuo
   Feng, Zhiwei
   Weng, Xiaogang
   Yu, Lili
TI Role of the inflammasome in insulin resistance and type 2 diabetes
   mellitus
SO FRONTIERS IN IMMUNOLOGY
LA English
DT Review
DE inflammasome; insulin resistance; type 2 diabetes mellitus; therapeutic
   agents; NLRP3
ID NLRP3 INFLAMMASOME; SIGNALING PATHWAYS; METABOLIC SYNDROME; OXIDATIVE
   STRESS; REGULATED NLRP3; GENE FAMILY; PPAR-GAMMA; ACTIVATION; OBESITY;
   COMPLEMENT
AB The inflammasome is a protein complex composed of a variety of proteins in cells and which participates in the innate immune response of the body. It can be activated by upstream signal regulation and plays an important role in pyroptosis, apoptosis, inflammation, tumor regulation, etc. In recent years, the number of metabolic syndrome patients with insulin resistance (IR) has increased year by year, and the inflammasome is closely related to the occurrence and development of metabolic diseases. The inflammasome can directly or indirectly affect conduction of the insulin signaling pathway, involvement the occurrence of IR and type 2 diabetes mellitus (T2DM). Moreover, various therapeutic agents also work through the inflammasome to treat with diabetes. This review focuses on the role of inflammasome on IR and T2DM, pointing out the association and utility value. Briefly, we have discussed the main inflammasomes, including NLRP1, NLRP3, NLRC4, NLRP6 and AIM2, as well as their structure, activation and regulation in IR were described in detail. Finally, we discussed the current therapeutic options-associated with inflammasome for the treatment of T2DM. Specially, the NLRP3-related therapeutic agents and options are widely developed. In summary, this article reviews the role of and research progress on the inflammasome in IR and T2DM.
C1 [Lu, Shen; Qian, Zhaojun; Weng, Xiaogang; Yu, Lili] Xinxiang Med Univ, Affiliated Hosp 3, Xinxiang, Henan, Peoples R China.
   [Li, Yanrong; Zhao, Tiesuo; Feng, Zhiwei; Yu, Lili] Xinxiang Med Univ, Sch Basic Med Sci, Xinxiang, Henan, Peoples R China.
   [Li, Yanrong; Zhao, Tiesuo; Feng, Zhiwei; Yu, Lili] Xinxiang Med Univ, Inst Precis Med, Xinxiang, Henan, Peoples R China.
   [Zhao, Tiesuo; Feng, Zhiwei; Yu, Lili] Xinxiang Med Univ, Xinxiang Key Lab Tumor Vaccine & Immunotherapy, Xinxiang, Henan, Peoples R China.
C3 Xinxiang Medical University; Xinxiang Medical University; Xinxiang
   Medical University; Xinxiang Medical University
RP Weng, XG; Yu, LL (corresponding author), Xinxiang Med Univ, Affiliated Hosp 3, Xinxiang, Henan, Peoples R China.; Yu, LL (corresponding author), Xinxiang Med Univ, Sch Basic Med Sci, Xinxiang, Henan, Peoples R China.; Yu, LL (corresponding author), Xinxiang Med Univ, Inst Precis Med, Xinxiang, Henan, Peoples R China.; Yu, LL (corresponding author), Xinxiang Med Univ, Xinxiang Key Lab Tumor Vaccine & Immunotherapy, Xinxiang, Henan, Peoples R China.
EM wengxiaogang@aliyun.com; merrys222@126.com
RI jia, xiaolong/HII-6615-2022; FENG, ZHIWEI/L-5072-2014
FU National Natural Science Foundation of China [81500675, 82070895,
   81671226]; Research and Innovation Support Program for Graduate Students
   of Xinxiang Medical University [YJSCX202105Y]; Open Project Program of
   the Third Affiliated Hospital of Xinxiang Medical University
   [KFKTYB202115]; Natural Science Foundation of Henan Province
FX This work was supported by grants from the National Natural Science
   Foundation (81500675, 82070895, and 81671226) of China, Research and
   Innovation Support Program for Graduate Students of Xinxiang Medical
   University (YJSCX202105Y), Open Project Program of the Third Affiliated
   Hospital of Xinxiang Medical University (No. KFKTYB202115) and Natural
   Science Foundation of Henan Province.
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NR 209
TC 40
Z9 42
U1 6
U2 30
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-3224
J9 FRONT IMMUNOL
JI Front. Immunol.
PD MAR 13
PY 2023
VL 14
AR 1052756
DI 10.3389/fimmu.2023.1052756
PG 22
WC Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology
GA A6PG2
UT WOS:000956315900001
PM 36993972
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Shobatake, R
   Ota, H
   Takahashi, N
   Ueno, S
   Sugie, K
   Takasawa, S
AF Shobatake, Ryogo
   Ota, Hiroyo
   Takahashi, Nobuyuki
   Ueno, Satoshi
   Sugie, Kazuma
   Takasawa, Shin
TI The Impact of Intermittent Hypoxia on Metabolism and Cognition
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE sleep apnea; intermittent hypoxia; appetite; obesity; diabetes; insulin
   resistance; hypertension; dementia; Alzheimer's disease; cognitive
   impairment
ID OBSTRUCTIVE SLEEP-APNEA; CYCLIC ADP-RIBOSE; DOPAMINE-BETA-HYDROXYLASE;
   CATECHOLAMINE BIOSYNTHETIC-ENZYMES; INTRACELLULAR CA2+ MOBILIZATION;
   INDUCED INSULIN-SECRETION; RYANODINE-RECEPTOR; BLOOD-PRESSURE;
   TYROSINE-HYDROXYLASE; UP-REGULATION
AB Intermittent hypoxia (IH), one of the primary pathologies of sleep apnea syndrome (SAS), exposes cells throughout the body to repeated cycles of hypoxia/normoxia that result in oxidative stress and systemic inflammation. Since SAS is epidemiologically strongly correlated with type 2 diabetes/insulin resistance, obesity, hypertension, and dyslipidemia included in metabolic syndrome, the effects of IH on gene expression in the corresponding cells of each organ have been studied intensively to clarify the molecular mechanism of the association between SAS and metabolic syndrome. Dementia has recently been recognized as a serious health problem due to its increasing incidence, and a large body of evidence has shown its strong correlation with SAS and metabolic disorders. In this narrative review, we first outline the effects of IH on the expression of genes related to metabolism in neuronal cells, pancreatic beta cells, hepatocytes, adipocytes, myocytes, and renal cells (mainly based on the results of our experiments). Next, we discuss the literature regarding the mechanisms by which metabolic disorders and IH develop dementia to understand how IH directly and indirectly leads to the development of dementia.
C1 [Shobatake, Ryogo; Ueno, Satoshi; Sugie, Kazuma] Nara Med Univ, Dept Neurol, 840 Shijo Cho, Kashihara, Nara 6348522, Japan.
   [Shobatake, Ryogo; Takahashi, Nobuyuki] Nara City Hosp, Dept Neurol, I-50-1 Higashikidera Cho, Nara 6308305, Japan.
   [Shobatake, Ryogo; Takasawa, Shin] Nara Med Univ, Dept Biochem, 840 Shijo Cho, Kashihara, Nara 6348521, Japan.
   [Ota, Hiroyo] Nara Med Univ, Dept Resp Med, 840 Shijo Cho, Kashihara, Nara 6348522, Japan.
C3 Nara Medical University; Nara Medical University; Nara Medical
   University
RP Shobatake, R (corresponding author), Nara Med Univ, Dept Neurol, 840 Shijo Cho, Kashihara, Nara 6348522, Japan.; Shobatake, R (corresponding author), Nara City Hosp, Dept Neurol, I-50-1 Higashikidera Cho, Nara 6308305, Japan.; Shobatake, R (corresponding author), Nara Med Univ, Dept Biochem, 840 Shijo Cho, Kashihara, Nara 6348521, Japan.
EM rshobatake@naramed-u.ac.jp
RI Takahashi, Nobuyuki/ABB-8784-2020
OI Shobatake, Ryogo/0000-0002-4165-1200; Sugie, Kazuma/0000-0003-0148-4687;
   Takasawa, Shin/0000-0002-4066-0199
FU Ministry of Education, Culture, Sports, Science and Technology, Japan
   [08102003, 15K19425, 21K16344]; Japan Society for the Promotion of
   Science; Japan Science and Technology Agency; Grants-in-Aid for
   Scientific Research [21K16344] Funding Source: KAKEN
FX This research was supported in part by the Grant-in-Aid for Scientific
   Research from the Ministry of Education, Culture, Sports, Science and
   Technology, Japan (grant numbers 08102003, 15K19425, and 21K16344), the
   Japan Society for the Promotion of Science, and the Japan Science and
   Technology Agency.
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NR 177
TC 20
Z9 22
U1 2
U2 16
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD NOV
PY 2022
VL 23
IS 21
AR 12957
DI 10.3390/ijms232112957
PG 20
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 6B3XQ
UT WOS:000881270300001
PM 36361741
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Sanches, IC
   Brito, JD
   Candido, GO
   Dias, DD
   Jorge, L
   Irigoyen, MC
   De Angelis, K
AF Sanches, Iris Callado
   Brito, Janaina de Oliveira
   Candido, Georgia Orsi
   Dias, Danielle da Silva
   Jorge, Luciana
   Irigoyen, Maria-Claudia
   De Angelis, Katia
TI Cardiometabolic benefits of exercise training in an experimental model
   of metabolic syndrome and menopause
SO MENOPAUSE-THE JOURNAL OF THE MENOPAUSE SOCIETY
LA English
DT Article
DE Exercise training; Menopause; Hypertension; Metabolic syndrome;
   Fructose; Autonomic control
ID SPONTANEOUSLY HYPERTENSIVE-RATS; BLOOD-PRESSURE; INSULIN-RESISTANCE;
   OXIDATIVE STRESS; AUTONOMIC DYSFUNCTION; FRUCTOSE; SENSITIVITY;
   ESTROGEN; GAIN
AB Objective: The aim of this study was to investigate the cardiometabolic effects of exercise training in ovariectomized hypertensive rats both submitted and not submitted to fructose overload.
   Methods: Spontaneously hypertensive ovariectomized rats were divided into sedentary and trained (THO) groups submitted to normal chow and sedentary and trained groups submitted to fructose overload (100 g/L in drinking water for 19 wk). Exercise training was performed on a treadmill (8 wk). Arterial pressure (AP) was directly recorded. Cardiovascular autonomic control was evaluated through pharmacological blockade (atropine and propranolol) and in the time and frequency domains by spectral analysis.
   Results: The THO group presented reduced AP (approximately 16 mm Hg) and enhanced cardiac vagal tonus (approximately 49%) and baroreflex sensitivity (approximately 43%) compared with the sedentary hypertensive ovariectomized group. Exercise training attenuated metabolic impairment, resting tachycardia, cardiac and vascular sympathetic increases, and baroreflex sensitivity decrease induced by fructose overload in hypertensive rats. However, the trained hypertensive ovariectomized group submitted to fructose overload presented higher AP (approximately 32 mm Hg), associated with baroreflex sensitivity (approximately 69%) and parasympathetic dysfunctions compared with the THO group.
   Conclusions: These data suggest that the metabolic disorders in hypertensive rats after ovarian hormone deprivation could blunt and/or attenuate some exercise training benefits.
C1 [De Angelis, Katia] Nove de Julho Univ, Sci Rehabil Program, Lab Translat Physiol, BR-05001100 Sao Paulo, Brazil.
   [Candido, Georgia Orsi; Jorge, Luciana; Irigoyen, Maria-Claudia] Univ Sao Paulo, Inst Heart, Hypertens Unit, Sao Paulo, Brazil.
C3 Universidade Nove de Julho; Universidade de Sao Paulo
RP De Angelis, K (corresponding author), Nove de Julho Univ, Sci Rehabil Program, Lab Translat Physiol, Av Francisco Matarazzo 612,1 Andar, BR-05001100 Sao Paulo, Brazil.
EM prof.kangelis@uninove.br
RI da Silva Dias, Danielle/AAN-7618-2020; Jorge, Luciana/AAG-4015-2021;
   Irigoyen, maria Claudia/N-6880-2014; DE ANGELIS, KATIA/I-6098-2016;
   Sanches, Iris Callado/D-5079-2013
OI Irigoyen, maria Claudia/0000-0003-2097-3662; DE ANGELIS,
   KATIA/0000-0002-3640-9049; Sanches, Iris Callado/0000-0001-6195-4340
FU Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior
   (CAPES-PROSUP); Fundacao de Amparo a Pesquisa do Estado de Sao Paulo
   (FAPESP) [2007/57595-5, 2007/52419-4, 2010/17188-4]; CNPq-BPQ; Fundacao
   de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [10/17188-4]
   Funding Source: FAPESP
FX This study was supported by Coordenacao de Aperfeicoamento de Pessoal de
   Nivel Superior (CAPES-PROSUP) and Fundacao de Amparo a Pesquisa do
   Estado de Sao Paulo (FAPESP: 2007/57595-5, 2007/52419-4, 2010/17188-4).
   K. De Angelis and M.C. Irigoyen are the recipients of CNPq-BPQ
   fellowships.
CR [Anonymous], ARTERIOSCLER THROMB
   [Anonymous], AUTON NEUROSCI
   [Anonymous], AM J PHYSL HEART CIR
   [Anonymous], CIRCULATION
   [Anonymous], CLIN SCI
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NR 42
TC 29
Z9 31
U1 0
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1072-3714
EI 1530-0374
J9 MENOPAUSE
JI Menopause-J. Menopause Soc..
PD MAY
PY 2012
VL 19
IS 5
BP 562
EP 568
DI 10.1097/gme.0b013e3182358c9c
PG 7
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA 934AN
UT WOS:000303411200014
PM 22157682
DA 2025-06-11
ER

PT J
AU Grau, T
   Bonet, A
AF Grau, Teodoro
   Bonet, Alfonso
TI Caloric intake and liver dysfunction in critically ill patients
SO CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE
LA English
DT Article
DE critically ill; energy requirements; insulin resistance; liver
   dysfunction; overfeeding
ID DE-NOVO LIPOGENESIS; INSULIN-RESISTANCE; GLUCOSE-METABOLISM; MECHANISMS;
   NUTRITION; STRESS; HUMANS; MORTALITY
AB Purpose of review
   Despite increasing evidence that critically ill patients have lower energy requirements than expected, most guidelines continue to recommend elevated caloric requirements in h patients, particularly in septic patients. This practice leads to liver dysfunction when artificial nutrition is employed and worsens the prognosis of these patients. This review is focused on recent developments in the pathogenesis of artificial nutrition associated liver dysfunction in critically ill patients.
   Recent findings
   The liver plays a pivotal role in managing nutritional substrates, and it is involved in the inflammatory response to injury and sepsis. The landmark phenomenon is insulin resistance and changes in the metabolic fates of glucose and fat. Glucose and lipids can act as toxics synergistically with inflammation to induce liver dysfunction. There are experimental evidences that insulin resistance in critically ill patients can share the same biochemical mechanisms and metabolic fates involved in insulin resistance of type 2 diabetes mellitus and metabolic syndrome. Furthermore, steatosis is also a common feature in both clinical pictures
   Summary
   The pathogenesis of artificial nutrition associated with liver dysfunction is related to overfeeding and sepsis with a pathophysiology, similar to metabolic syndrome and type 2 diabetes. Changing nutritional strategies and adding new drugs will prevent, in part, liver dysfunction in these patients.
C1 [Grau, Teodoro] Hosp Univ Doce Octubre, Dept Intens Care, Madrid 28041, Spain.
   [Bonet, Alfonso] Hosp Josep Trueta, Dept Intens Care, Girona, Spain.
C3 Hospital Universitario 12 de Octubre; Universitat de Girona; Girona
   University Hospital Dr. Josep Trueta
RP Grau, T (corresponding author), Hosp Univ Doce Octubre, Dept Intens Care, Av Corboda S-N, Madrid 28041, Spain.
EM tgrau.hdoc@salud.madrid.org
RI Grau, Teodoro/J-5127-2019
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TC 27
Z9 30
U1 1
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1363-1950
EI 1473-6519
J9 CURR OPIN CLIN NUTR
JI Curr. Opin. Clin. Nutr. Metab. Care
PD MAR
PY 2009
VL 12
IS 2
BP 175
EP 179
DI 10.1097/MCO.0b013e3283252f9e
PG 5
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 420DK
UT WOS:000264268500012
PM 19202389
DA 2025-06-11
ER

PT J
AU Ghayour-Mobarhan, M
   Yaghootkar, H
   Lanham-New, SA
   Lamb, DJ
   Ferns, GA
AF Ghayour-Mobarhan, Majid
   Yaghootkar, Hanyeh
   Lanham-New, Suzan A.
   Lamb, David J.
   Ferns, Gordon A.
TI Association between serum CRP concentrations with dietary intake in
   healthy and dyslipidaemic patients
SO ASIA PACIFIC JOURNAL OF CLINICAL NUTRITION
LA English
DT Article
DE CRP; dyslipidaemia; dietary intake; atherosclerosis; inflammation
ID C-REACTIVE PROTEIN; METABOLIC SYNDROME; FATTY-ACIDS; RISK-FACTORS;
   PLASMA; STRESS
AB Serum CRP concentrations are elevated in subjects at risk of coronary events and in subjects with metabolic syndrome. Although dietary fat and antioxidants are known for their immune-modulating actions, their reported effects on CRP concentrations have been inconsistent. In the present study we have investigated whether dietary constituents are associated with serum CRP concentrations in healthy subjects and patients with dyslipidaemic. Dyslipidaemic subjects (n=238) were recruited from Hospital Outpatient Clinics in Guilford, UK. Apparently healthy subjects (n=188) were recruited from amongst adjacent University and Hospital employees. A validated food frequency questionnaire was used to estimate dietary intake. Dyslipidaemic patients had higher serum CRP [1.25 (0.42-3.26) mg/L] than control subjects [0.50 (0.17-1.42) mg/L] (p<0.001). In the dyslipidaemic patients, approximately 4% of the variation in serum CRP could be explained by dietary cholesterol intake (p = 0.015, 2.8%), and weakly by dietary vitamin C intake (p = 0.06, 1.2%). No relationship between dietary constituents and serum CRP concentrations was found among the healthy subjects. Hence the present study shows that serum CRP concentrations are increased in patients with classical coronary risk factors, and that they may be modulated by dietary cholesterol.
C1 Univ Surrey, Sch Biomed & Mol Sci, Ctr Clin Sci & Measurement, Guildford GU2 7XH, Surrey, England.
   Univ Surrey, Sch Biomed & Life Sci, Ctr Nutr & Food Safety, Guildford GU2 7XH, Surrey, England.
   Royal Surrey Cty Hosp, Dept Clin Biochem, Surrey GU2 7XX, England.
   Mashad Univ Med Sci, Fac Med, Mashhad, Iran.
C3 University of Surrey; University of Surrey; Royal Surrey County
   Hospital; Mashhad University of Medical Sciences
RP Ferns, GA (corresponding author), Univ Surrey, Sch Biol Sci, Ctr Clin Sci & Measurement, Guildford GU2 5XH, Surrey, England.
EM g.ferns@surrey.ac.uk
RI Ghayour-Mobarhan, Majid/AAY-5963-2020
OI , Hanieh/0000-0001-9672-9477; Lanham-New, Susan/0000-0003-3153-6345
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NR 35
TC 4
Z9 7
U1 0
U2 3
PU H E C PRESS, HEALTHY EATING CLUB PTY LTD
PI MCKINNON
PA PO BOX 4121, MCKINNON, VIC 3204, AUSTRALIA
SN 0964-7058
EI 1440-6047
J9 ASIA PAC J CLIN NUTR
JI Asia Pac. J. Clin. Nutr.
PY 2007
VL 16
IS 2
BP 262
EP 268
PG 7
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 171DO
UT WOS:000246715300009
PM 17468081
DA 2025-06-11
ER

PT J
AU Lin, CH
   Lin, TH
   Pan, TM
AF Lin, Chih-Hui
   Lin, Tzu-Hsing
   Pan, Tzu-Ming
TI Alleviation of metabolic syndrome by monascin and ankaflavin: the
   perspective of Monascus functional foods
SO FOOD & FUNCTION
LA English
DT Review
ID DEEP-OCEAN WATER; HIGH-FAT DIET; MONACOLIN-K; PPAR-GAMMA; OXIDATIVE
   STRESS; PIGMENT BIOSYNTHESIS; FERMENTED PRODUCTS; INSULIN-RESISTANCE;
   TNF-ALPHA; INFLAMMATION
AB The metabolites of Monascus with multiple benefits are popular subjects for the development of functional foods. The yellow pigments, monascin and ankaflavin, which are the constituent metabolites of M. purpureus, M. pilosus and M. ruber, are becoming the focus of research on Monascus. Monascin and ankaflavin are azaphilone compounds with similar structures that exhibit multiple beneficial effects including anti-inflammation, anti-oxidation, anti-diabetes, immunomodulation, attenuation of Alzheimer's disease risk factor, and anti-tumorigenic effects. Monascin and ankaflavin not only possess pleiotropic bioactivities, but are also more potent than monacolin K in lowering lipid levels and have lower toxicity. Monascin and ankaflavin act as the activators of PPAR. agonist/Nrf-2 that subsequently ameliorate metabolic syndrome. Following the intensive exploration of Monascus bioactivities in recent years, the focus of research on Monascus-functional foods has shifted from whole fermented products/extracts to specific bioactive compounds. Therefore, the production of monascin and ankaflavin is an important topic with respect to Monascus-functional foods. Although several genomic studies have paved the way for understanding the production of secondary metabolites in Monascus, efforts are still required to effectively manipulate the biosynthesis of secondary metabolites with genetic engineering and/or culture techniques.
C1 [Lin, Chih-Hui; Lin, Tzu-Hsing] Natl Taitung Univ, Dept Life Sci, 369,Sec 2,Univ Rd, Taitung, Taiwan.
   [Pan, Tzu-Ming] Natl Taiwan Univ, Coll Life Sci, Dept Biochem Sci & Technol, 1,Sec 4,Roosevelt Rd, Taipei, Taiwan.
C3 National Taiwan University
RP Lin, CH (corresponding author), Natl Taitung Univ, Dept Life Sci, 369,Sec 2,Univ Rd, Taitung, Taiwan.; Pan, TM (corresponding author), Natl Taiwan Univ, Coll Life Sci, Dept Biochem Sci & Technol, 1,Sec 4,Roosevelt Rd, Taipei, Taiwan.
EM tmpan@ntu.edu.tw
RI Pan, Tzu-Ming/KHX-6323-2024
OI Lin, Chih-Hui/0000-0002-6456-2649
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NR 61
TC 41
Z9 54
U1 3
U2 122
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PD JUN 1
PY 2017
VL 8
IS 6
BP 2102
EP 2109
DI 10.1039/c7fo00406k
PG 8
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA EY9UU
UT WOS:000404345100003
PM 28608901
DA 2025-06-11
ER

PT J
AU Yu, JW
   Lee, MS
AF Yu, Je-Wook
   Lee, Myung-Shik
TI Mitochondria and the NLRP3 inflammasome: physiological and pathological
   relevance
SO ARCHIVES OF PHARMACAL RESEARCH
LA English
DT Review
DE Interleukin 1; Innate immunity; ROS; Metabolic syndrome;
   Neurodegeneration
ID NF-KAPPA-B; LINKS OXIDATIVE STRESS; ISCHEMIA-REPERFUSION; MACULAR
   DEGENERATION; NALP3 INFLAMMASOME; PARKINSONS-DISEASE; DENDRITIC CELLS;
   HOST-DEFENSE; MITOFUSIN 2; K+ EFFLUX
AB The NLRP3 inflammasome is assembled and activated in certain types of myeloid cells upon sensing microbe-derived toxins or host-derived danger signals. Activation of the NLRP3 inflammasome by endogenous ligands has been discovered in various disorders, including metabolic syndrome, type 2 diabetes, atherosclerosis, gout, reperfusion injury of the heart, neurodegeneration, such as Alzheimer's disease, chronic kidney diseases, and macular degeneration of the eyes. Despite the potential significance of the NLRP3 inflammasome in the pathogenesis of several diseases, details on the activation mechanism of the NLRP3 inflammasome by a variety of stimulators have yet to be reported. Emerging evidence suggests that mitochondrial events are associated with NLRP3 activation in disease conditions. Mitochondrial dysfunction acts upstream of NLRP3 activation by providing reactive oxygen species ( ROS) to trigger NLRP3 oligomerization or by inducing alpha-tubulin acetylation to relocate mitochondria to the proximity of NLRP3. In addition, mitochondria work as a platform for inflammasome assembly. Mitochondrial events may also lie downstream of NLRP3 activation. While the molecular mechanisms of mitochondrial dysfunction associated with NLRP3 activation are still unclear, they may involve the perturbation of mitochondria by K+ efflux and subsequent intracellular disequilibrium. Thus, mitochondria and NLRP3 machinery appear to be closely interwoven at multiple levels.
C1 [Yu, Je-Wook] Yonsei Univ, Coll Med, Dept Microbiol & Immunol, BK PLUS Project Med Sci 21, Seoul 03722, South Korea.
   [Lee, Myung-Shik] Yonsei Univ, Coll Med, Severance Biomed Sci Inst, 50-1 Yonsei Ro, Seoul 03722, South Korea.
   [Lee, Myung-Shik] Yonsei Univ, Coll Med, Dept Internal Med, 50-1 Yonsei Ro, Seoul 03722, South Korea.
C3 Yonsei University; Yonsei University Health System; Yonsei University;
   Yonsei University Health System; Yonsei University; Yonsei University
   Health System
RP Lee, MS (corresponding author), Yonsei Univ, Coll Med, Severance Biomed Sci Inst, 50-1 Yonsei Ro, Seoul 03722, South Korea.; Lee, MS (corresponding author), Yonsei Univ, Coll Med, Dept Internal Med, 50-1 Yonsei Ro, Seoul 03722, South Korea.
EM mslee0923@yuhs.ac
RI Lee, Myung/C-9606-2011
OI Lee, Myung-Shik/0000-0003-3292-1720; Yu, Je-Wook/0000-0001-5943-4071
FU Bio & Medical Technology Development Program Fund of the National
   Research Foundation [NRF-2015M3A9B6073846, NRF-2015M3A9B6073856]; NRF
   [NRF-2013R1A2A2A01067985]; Global Research Laboratory Grant of the
   National Research Foundation of Korea [K21004000003-12A0500-00310];
   Ulsan National Institute of Science and Technology Research Fund
   [2014M3A9D8034459]
FX This study was supported by Bio & Medical Technology Development Program
   Fund of the National Research Foundation (NRF-2015M3A9B6073846,
   NRF-2015M3A9B6073856), and the NRF grant (NRF-2013R1A2A2A01067985). M-SL
   is the recipient of the Global Research Laboratory Grant of the National
   Research Foundation of Korea (K21004000003-12A0500-00310) and the Ulsan
   National Institute of Science and Technology Research Fund
   (2014M3A9D8034459).
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NR 134
TC 161
Z9 173
U1 1
U2 51
PU PHARMACEUTICAL SOC KOREA
PI SEOUL
PA 1489-3 SUHCHO-DONG, SUHCHO-KU, SEOUL 137-071, SOUTH KOREA
SN 0253-6269
EI 1976-3786
J9 ARCH PHARM RES
JI Arch. Pharm. Res.
PD NOV
PY 2016
VL 39
IS 11
SI SI
BP 1503
EP 1518
DI 10.1007/s12272-016-0827-4
PG 16
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA ED4WZ
UT WOS:000388853900002
PM 27600432
DA 2025-06-11
ER

PT J
AU Montefusco-Pereira, CV
   de Carvalho, MJ
   Boleti, APD
   Teixeira, LS
   Matos, HR
   Lima, ES
AF Montefusco-Pereira, Carlos Victor
   de Carvalho, Maria Jose
   de Araujo Boleti, Ana Paula
   Teixeira, Lorisa Simas
   Matos, Humberto Reis
   Lima, Emerson Silva
TI Antioxidant, Anti-inflammatory, and Hypoglycemic Effects of the Leaf
   Extract from Passiflora nitida Kunth
SO APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
LA English
DT Article
DE Passiflora nitida; Diabetes mellitus; Amazon plants; Extract plants
ID ALPHA-GLUCOSIDASE; BLOOD-GLUCOSE; ACID; RAT
AB Diabetes mellitus is a metabolic disease characterized by abnormally high plasma glucose levels, leading to major complications, such as insulin resistance, obesity, hyperlipidemia, and hypertension, also with alterations in the immune and neuronal systems. Brazilian plants have been studied as important sources for new molecules with medicinal properties. The genus Passiflora known as "Maracuja" has been used as a traditional folk medicine for a long time, so an investigation was performed regarding an endemic kind of passion fruit (Passiflora nitida Kunth) from Amazonas, Brazil. Here, we aimed to determine its potential biological activity against metabolic syndrome, oxidative stress, pain, and inflammation. The hydroethanol leaf extract revealed an in vitro alpha-glucosidase inhibitory activity of 50 % inhibitory concentration (IC50) = 6.78 +/- 0.31 mu g/mL and an alpha-amylase inhibition of IC50 = 93.36 +/- 4.37. In vivo, experiments of different saccharide tolerance resulted in significant glycemia control and, with alloxan-diabetic mice, resulted in a decrease of total cholesterol, a hypoglycemic effect, and an antioxidant activity by thiobarbituric acid-reactive substances measurement. Also, it decreased the carrageenan-induced edema volume and the rate of writhing as a nociceptive response. These results indicate positive effects of P. nitida extract and its potential to inhibit metabolic syndrome.
C1 [Montefusco-Pereira, Carlos Victor; de Carvalho, Maria Jose; de Araujo Boleti, Ana Paula; Teixeira, Lorisa Simas; Matos, Humberto Reis; Lima, Emerson Silva] Amazonas Fed Univ, Lab Biol Act, Fac Pharmaceut Sci, BR-69010300 Manaus, Amazonas, Brazil.
RP Lima, ES (corresponding author), Amazonas Fed Univ, Lab Biol Act, Fac Pharmaceut Sci, Alexandre Amorim St 330, BR-69010300 Manaus, Amazonas, Brazil.
EM eslima@ufam.edu.br
RI ; Silva Lima, Emerson/L-4553-2016; Araujo Boleti, Ana Paula/F-3433-2019
OI Montefusco Pereira, Carlos Victor/0000-0003-4167-4653; Silva Lima,
   Emerson/0000-0002-9367-2812; Araujo Boleti, Ana
   Paula/0000-0003-0253-8907
FU Foundation for the Support of Research in the State of Amazonas
   (FAPEAM); National Council for Scientific and Technological Development
   (CNPq)
FX The authors are grateful for the financial support provided by the
   Foundation for the Support of Research in the State of Amazonas (FAPEAM)
   and the National Council for Scientific and Technological Development
   (CNPq). E. S. L. and H. R. M. are members of the INCT de Processos Redox
   em Biomedicina-Redoxoma (MCT/CNPq). A.P.A.B is a researcher of Programa
   de Desenvolvimento Cientifico Regional (DCR-FAPEAM). Jim Hesson of
   Academic English Solutions.com proofread the text.
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Z9 25
U1 1
U2 30
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0273-2289
EI 1559-0291
J9 APPL BIOCHEM BIOTECH
JI Appl. Biochem. Biotechnol.
PD JUL
PY 2013
VL 170
IS 6
BP 1367
EP 1378
DI 10.1007/s12010-013-0271-6
PG 12
WC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology
GA 175EO
UT WOS:000321213600008
PM 23666642
DA 2025-06-11
ER

PT J
AU Farahmandpour, F
   Haidari, F
   Heidari, Z
   Hajarzadeh, S
   Ahangarpour, A
AF Farahmandpour, Fatemeh
   Haidari, Fatemeh
   Heidari, Zeinab
   Hajarzadeh, Samaneh
   Ahangarpour, Akram
TI Whey Protein Intervention and Inflammatory Factors and Oxidative Stress:
   Systematic Review and Meta-analysis of Randomized Controlled Trials
SO NUTRITION REVIEWS
LA English
DT Review
DE whey protein; inflammatory factors; oxidative stress; meta-analysis;
   systematic review
ID CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; SUPPLEMENTATION; OVERWEIGHT;
   MARKERS; BLOOD; RISK
AB Context Whey protein (WP), a high-biological-value protein contained in milk, may have anti-inflammatory properties and can reduce proinflammatory cytokines; however, the current evidence is inconclusive.Objective The aim of this study was to further investigate the effects of whey protein supplementation on inflammatory factors and oxidative stress in adults.Data Sources We conducted a comprehensive search up to March 2022 using relevant key words in databases such as PubMed, Scopus, Embase, and the Cochrane Central Register of Controlled Trials, focusing on randomized controlled trials (RCTs).Data Extraction RCTs that examined the impact of WP on C-reactive protein, tumor necrosis factor alpha, interleukin-6, glutathione, malondialdehyde, and total antioxidant capacity were selected independently by 2 authors. Results were pooled using a random-effects model as weighted mean differences and 95% CIs.Data Analysis The results of the present study demonstrated that WP supplementation had no significant effect on the modulation of inflammation and oxidative stress compared with the control. None of the predefined subgroup analyses explained the differences in the effects of WP supplementation on inflammatory factors and oxidative stress.Conclusion This research suggests that WP supplementation had no significant effect on inflammatory factors and oxidative stress.Systematic Review Registration PROSPERO registration no. CRD42022325855.
C1 [Farahmandpour, Fatemeh; Heidari, Zeinab; Hajarzadeh, Samaneh] Ahvaz Jundishapur Univ Med Sci, Student Res Comm, Ahvaz 6135715794, Iran.
   [Haidari, Fatemeh] CQ Univ, Sch Hlth Med & Appl Sci, Brisbane 4701, Australia.
   [Ahangarpour, Akram] Ahvaz Jundishapur Univ Med Sci, Med Basic Sci Res Inst, Persian Gulf Physiol Res Ctr, Dept Physiol, Ahvaz 6135715794, Iran.
C3 Ahvaz Jundishapur University of Medical Sciences (AJUMS); Central
   Queensland University; Ahvaz Jundishapur University of Medical Sciences
   (AJUMS)
RP Ahangarpour, A (corresponding author), Ahvaz Jundishapur Univ Med Sci, Med Basic Sci Res Inst, Persian Gulf Physiol Res Ctr, Dept Physiol, Ahvaz 6135715794, Iran.
EM akramahangarpour@gmail.com
RI ahangarpour, akram/I-7638-2017; Heidari, Zeinab/AAX-7772-2020; Haidari,
   Fatemeh/K-4157-2018
FU Research Affairs of Jundishapur University of Medical Sciences, Ahvaz,
   Iran [IR.AJUMS.REC.1401.1409, 01S53]
FX This work was financially (01S53) supported by the Research Affairs of
   Jundishapur University of Medical Sciences, Ahvaz, Iran
   (IR.AJUMS.REC.1401.1409)
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NR 42
TC 0
Z9 0
U1 1
U2 4
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0029-6643
EI 1753-4887
J9 NUTR REV
JI Nutr. Rev.
PD AUG 28
PY 2024
VL 83
IS 4
BP 609
EP 621
DI 10.1093/nutrit/nuae100
EA AUG 2024
PG 13
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA Z7W1J
UT WOS:001299289800001
PM 39196774
DA 2025-06-11
ER

PT J
AU Martínez-Martínez, E
   Souza-Neto, FV
   Jiménez-Gonzalez, S
   Cachofeiro, V
AF Martinez-Martinez, Ernesto
   V. Souza-Neto, Francisco
   Jimenez-Gonzalez, Sara
   Cachofeiro, Victoria
TI Oxidative Stress and Vascular Damage in the Context of Obesity: The
   Hidden Guest
SO ANTIOXIDANTS
LA English
DT Review
DE endoplasmic reticulum stress; obesity; oxidative stress; vascular
   damage; perivascular adipose tissue
ID PERIVASCULAR ADIPOSE-TISSUE; ENDOPLASMIC-RETICULUM STRESS; HIGH-FAT
   DIET; MEDIATES ENDOTHELIAL DYSFUNCTION; NITRIC-OXIDE PRODUCTION;
   INSULIN-RESISTANCE; MINERALOCORTICOID RECEPTOR; ARTERIAL STIFFNESS;
   METABOLIC SYNDROME; REACTIVE OXYGEN
AB The vascular system plays a central role in the transport of cells, oxygen and nutrients between different regions of the body, depending on the needs, as well as of metabolic waste products for their elimination. While the structure of different components of the vascular system varies, these structures, especially those of main arteries and arterioles, can be affected by the presence of different cardiovascular risk factors, including obesity. This vascular remodeling is mainly characterized by a thickening of the media layer as a consequence of changes in smooth muscle cells or excessive fibrosis accumulation. These vascular changes associated with obesity can trigger functional alterations, with endothelial dysfunction and vascular stiffness being especially common features of obese vessels. These changes can also lead to impaired tissue perfusion that may affect multiple tissues and organs. In this review, we focus on the role played by perivascular adipose tissue, the activation of the renin-angiotensin-aldosterone system and endoplasmic reticulum stress in the vascular dysfunction associated with obesity. In addition, the participation of oxidative stress in this vascular damage, which can be produced in the perivascular adipose tissue as well as in other components of the vascular wall, is updated.
C1 [Martinez-Martinez, Ernesto; V. Souza-Neto, Francisco; Jimenez-Gonzalez, Sara; Cachofeiro, Victoria] Univ Complutense Madrid, Inst Invest Sanit Gregorio Maranon IiSGM, Fac Med, Dept Fisiol, Madrid 28040, Spain.
   [Martinez-Martinez, Ernesto; Cachofeiro, Victoria] Inst Salud Carlos III, Ciber Enfermedades Cardiovasc CIBERCV, Madrid 28040, Spain.
C3 Complutense University of Madrid; CIBER - Centro de Investigacion
   Biomedica en Red; CIBERCV; Instituto de Salud Carlos III
RP Martínez-Martínez, E; Cachofeiro, V (corresponding author), Univ Complutense Madrid, Inst Invest Sanit Gregorio Maranon IiSGM, Fac Med, Dept Fisiol, Madrid 28040, Spain.; Martínez-Martínez, E; Cachofeiro, V (corresponding author), Inst Salud Carlos III, Ciber Enfermedades Cardiovasc CIBERCV, Madrid 28040, Spain.
EM ernmarti@ucm.es; franvasc@ucm.es; saraji02@ucm.es; vcara@ucm.es
RI Martinez-Martinez, Ernesto/M-1376-2017
OI Martinez-Martinez, Ernesto/0000-0002-3011-2041; Jimenez-Gonzalez,
   Sara/0000-0002-8388-4678; Cachofeiro, Victoria/0000-0001-6959-6293
FU Instituto de Salud Carlos III-Fondo Europeo de Desarrollo Regional
   (FEDER) [PI18/00257, PI15/00742]; Universidad Complutense de Madrid y
   Banco Santander [CT42/18-CT43/18]; CAM [PEJD-2018-PRE/BMD-9171]
FX This research was funded by Instituto de Salud Carlos III-Fondo Europeo
   de Desarrollo Regional (FEDER) [grant numbers PI18/00257; PI15/00742;
   CIBERCV]. F.V.S-N was supported by a contract from Universidad
   Complutense de Madrid y Banco Santander (CT42/18-CT43/18) E.M-M was
   supported by a contract from CAM (Atraccion de talento) and S.J-G was
   supported by a contract from CAM (Ayuda de empleo juvenil
   PEJD-2018-PRE/BMD-9171).
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NR 236
TC 20
Z9 22
U1 1
U2 13
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD MAR
PY 2021
VL 10
IS 3
AR 406
DI 10.3390/antiox10030406
PG 24
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA RD2IU
UT WOS:000633309400001
PM 33800427
OA gold, Green Published, Green Accepted
DA 2025-06-11
ER

PT J
AU Bundalo, M
   Romic, S
   Tepavcevic, S
   Stojiljkovic, M
   Stankovic, A
   Zivkovic, M
   Koricanac, G
AF Bundalo, Maja
   Romic, Snjezana
   Tepavcevic, Snezana
   Stojiljkovic, Mojca
   Stankovic, Aleksandra
   Zivkovic, Maja
   Koricanac, Goran
TI Fructose-rich diet and insulin action in female rat heart: Estradiol
   friend or foe?
SO EUROPEAN JOURNAL OF PHARMACOLOGY
LA English
DT Article
DE Fructose-rich diet; Heart; Insulin; Estradiol
ID RENIN-ANGIOTENSIN SYSTEM; NITRIC-OXIDE; FATTY-ACID; OXIDATIVE STRESS;
   IN-VIVO; VASCULAR DYSFUNCTION; CARDIAC-HYPERTROPHY; SIGNALING PATHWAYS;
   METABOLIC SYNDROME; CONTAINING SUGARS
AB Increased intake of fructose in humans and laboratory animals is demonstrated to be a risk factor for development of metabolic disorders (insulin resistance, metabolic syndrome, type 2 diabetes) and cardiovascular diseases. On the other hand, estradiol is emphasized as a cardioprotective agent. The main goal of this review is to summarize recent findings on damaging cardiac effects of fructose-rich diet in females, mostly experimental animals, and to evaluate protective capacity of estradiol. Published results of our and other research groups indicate mostly detrimental effects of fructose-rich diet on cardiac insulin signaling molecules, glucose and fatty acid metabolism, nitric oxide production and ion transport, as well as renin-angiotensin system and inflammation. Some of these processes are involved in cardiac insulin signal transmission, others are regulated by insulin or have an influence on insulin action. Administration of estradiol to ovariectomized female rats, exposed to increased intake of fructose, was mostly beneficial to the heart, but sometimes it was ineffective or even detrimental, depending on the particular processes. We believe that these data, carefully translated to human population, could be useful for clinicians dealing with postmenopausal women susceptible to metabolic diseases and hormone replacement therapy.
C1 [Romic, Snjezana; Tepavcevic, Snezana; Stojiljkovic, Mojca; Koricanac, Goran] Univ Belgrade, Vinca Inst Nucl Sci, Lab Mol Biol & Endocrinol, Belgrade, Serbia.
   [Bundalo, Maja; Stankovic, Aleksandra; Zivkovic, Maja] Univ Belgrade, Vinca Inst Nucl Sci, Lab Radiobiol & Mol Genet, Belgrade, Serbia.
C3 University of Belgrade; University of Belgrade
RP Koricanac, G (corresponding author), Univ Belgrade, Vinca Inst Nucl Sci, Lab Mol Biol & Endocrinol, Belgrade, Serbia.
EM gogi@vin.bg.ac.rs
RI Korićanac, Goran/ABF-6544-2021; Zivkovic, Maja/T-1038-2018; Stankovic,
   Aleksandra/T-1064-2018
OI Romic, Snjezana/0000-0002-3346-7438; Stojiljkovic,
   Mojca/0000-0002-9041-7947; Zivkovic, Maja/0000-0002-0447-6626;
   Stankovic, Aleksandra/0000-0002-1050-5913; Tepavcevic,
   Snezana/0000-0002-5758-070X; Bundalo, Maja/0000-0002-0589-2672;
   Koricanac, Goran/0000-0002-9852-3330
FU Ministry of Education, Science and Technological Development, Republic
   of Serbia [41009, 175085]
FX This study was supported by the Ministry of Education, Science and
   Technological Development, Republic of Serbia (grant No. 41009 and grant
   No. 175085).
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NR 91
TC 5
Z9 6
U1 0
U2 6
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0014-2999
EI 1879-0712
J9 EUR J PHARMACOL
JI Eur. J. Pharmacol.
PD SEP 15
PY 2017
VL 811
BP 141
EP 147
DI 10.1016/j.ejphar.2017.06.003
PG 7
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA FH1EF
UT WOS:000410881800018
PM 28601616
DA 2025-06-11
ER

PT J
AU Kishimoto, A
   Dong, SF
   Negishi, H
   Yasui, N
   Sun, JN
   Ikeda, K
AF Kishimoto, Aya
   Dong, Shi-fen
   Negishi, Hiroko
   Yasui, Naomi
   Sun, Jian-ning
   Ikeda, Katsumi
TI Effects of Berberine on Adipose Tissues and Kidney Function in 3T3-L1
   Cells and Spontaneously Hypertensive Rats
SO NATURAL PRODUCT COMMUNICATIONS
LA English
DT Article
DE Berberine; Adipose tissues; 3T3-L1 cell; SHR; Renal injury
ID METABOLIC SYNDROME; OXIDATIVE STRESS; DYSFUNCTION
AB We aimed to investigate the effect of berberine on adipose tissues, as well as its effect on renal injury in 3T3-L1 cells and spontaneously hypertensive rats. 3T3-L1 cells were cultured and treated with berberine (5-20 mu M) from days 3 to 8. Berberine added to the cultured medium could significantly down-regulate transcription factors, including CCAAT/enhancer binding protein beta, CCAAT/enhancer binding protein alpha, and peroxisome proliferator-activated receptor gamma, and suppress peroxisome proliferator-activated receptor target genes, such as adipocyte fatty acid binding protein and fatty acid synthase, and inhibit 3T3-L1 fibroblast differentiation to adipocytes. Male spontaneously hypertensive rats received either 150 mg/day of berberine or saline orally for 8 weeks. Compared with the control, berberine-treated rats exhibited significant reductions in body weight gain (p<0.05), as well as retroperitoneal and mesenteric adipose tissues (p<0.05). Berberine-treated rats significantly decreased urinary albumin excretion, a marker of renal injury (p<0.05). Long-term treatment with berberine decreased the adipose tissues weight and attenuated renal injury in spontaneously hypertensive rats. Based on these results, berberine has an important role in regulating adipose tissues. These results suggest the protective effect of berberine on metabolic syndrome related diseases, such as renal injury.
C1 [Kishimoto, Aya; Negishi, Hiroko; Yasui, Naomi; Ikeda, Katsumi] Mukogawa Womens Univ, Sch Pharm & Pharmaceut Sci, Nishinomiya, Hyogo 6638179, Japan.
   [Dong, Shi-fen; Sun, Jian-ning] Beijing Univ Chinese Med, Sch Chinese Mat Med, Dept Pharmacol, Beijing 100029, Peoples R China.
C3 Mukogawa Women's University; Beijing University of Chinese Medicine
RP Kishimoto, A (corresponding author), Mukogawa Womens Univ, Sch Pharm & Pharmaceut Sci, Nishinomiya, Hyogo 6638179, Japan.
EM ikeda@mukogawa-u.ac.jp
RI Dong, Shifen/AAS-9769-2021
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NR 20
TC 5
Z9 5
U1 0
U2 5
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1934-578X
EI 1555-9475
J9 NAT PROD COMMUN
JI Nat. Prod. Commun.
PD SEP
PY 2015
VL 10
IS 9
BP 1543
EP 1546
PG 4
WC Chemistry, Medicinal; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Food Science & Technology
GA CS1ZZ
UT WOS:000361868900014
PM 26594754
DA 2025-06-11
ER

PT J
AU Jang, HH
   Hwang, IG
   Lee, YM
AF Jang, Hwan-Hee
   Hwang, In-Guk
   Lee, Young-Min
TI Effects of anthocyanin supplementation on blood lipid levels: a
   systematic review and meta-analysis
SO FRONTIERS IN NUTRITION
LA English
DT Article
DE metabolic syndrome; dyslipidemia; food supplementation; triglyceride;
   HDL cholesterol
ID CRANBERRY JUICE CONSUMPTION; DOUBLE-BLIND; ENDOTHELIAL FUNCTION;
   METABOLIC SYNDROME; POSTMENOPAUSAL WOMEN; ANTIOXIDANT CAPACITY;
   PLASMA-CHOLESTEROL; POMEGRANATE JUICE; VASCULAR FUNCTION; OXIDATIVE
   STRESS
AB Introduction: Dyslipidemia is amajor cardiovascular disease risk factor associated with increasedmortality. The intake of plant food-derived bioactive compounds is associated with beneficial cardiovascular effects, including decreased blood lipid levels and cardiovascular risk. We aimed to evaluate the e ects of anthocyanin intake on blood lipid levels by analyzing relevant randomized controlled trials.
   Methods: We searched the PubMed and Embase databases using the "Patient/Population, Intervention, Comparison, and Outcomes" format to determine whether anthocyanin supplementation intervention affected blood lipid levels compared with placebo supplementation in human participants.
   Results: A total of 41 studies with 2,788 participants were included in the meta-analysis. Anthocyanin supplementation significantly reduced triglyceride [standardized mean difference (SMD) = -0.10; 95% confidence interval [CI], -0.18, -0.01) and low-density lipoprotein-cholesterol (SMD = -0.16; 95% CI -0.26, -0.07) levels and increased high-density lipoprotein-cholesterol levels (SMD = 0.42; 95% CI 0.20, 0.65).
   Discussion: Anthocyanin supplementation significantly improved blood lipid component levels in the included studies. Larger, well-designed clinical trials are needed to further investigate the e ects of anthocyanin intake on blood lipid levels and the safety of anthocyanin supplementation for treating dyslipidemia.
C1 [Jang, Hwan-Hee; Hwang, In-Guk] Natl Inst Agr Sci, Rural Dev Adm, Funct Food & Nutr Div, Wonju, South Korea.
   [Lee, Young-Min] Gyeongin Natl Univ Educ, Dept Pract Sci Educ, Incheon, South Korea.
C3 Rural Development Administration (RDA), Republic of Korea; National
   Institute of Agricultural Sciences
RP Lee, YM (corresponding author), Gyeongin Natl Univ Educ, Dept Pract Sci Educ, Incheon, South Korea.
EM ymlee@ginue.ac.kr
RI Jang, HwanHee/KWT-7773-2024
FU This research was supported by the research program for Agricultural
   Science amp;amp; Technology Development under the National Institute of
   Agricultural Science (NAS)-Rural Development Administration (RDA), South
   Korea, under grant numbers PJ01420101 and [PJ01703102]; research program
   for Agricultural Science & Technology Development under the National
   Institute of Agricultural Science (NAS)-Rural Development Administration
   (RDA), South Korea [PJ01703102, PJ01420101]
FX This research was supported by the research program for Agricultural
   Science & Technology Development under the National Institute of
   Agricultural Science (NAS)-Rural Development Administration (RDA), South
   Korea, under grant numbers PJ01420101 and PJ01703102.
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NR 90
TC 9
Z9 9
U1 4
U2 8
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD AUG 15
PY 2023
VL 10
AR 1207751
DI 10.3389/fnut.2023.1207751
PG 14
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA Q5NO6
UT WOS:001057991100001
PM 37649528
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Stump, CS
AF Stump, Craig S.
TI Physical Activity in the Prevention of Chronic Kidney Disease
SO CARDIORENAL MEDICINE
LA English
DT Review
DE Cardiovascular disease; Chronic kidney disease; Diabetes; Exercise;
   Obesity; Physical activity; Renal function
ID BODY-MASS INDEX; CARDIORESPIRATORY FITNESS; METABOLIC SYNDROME;
   INSULIN-RESISTANCE; CARDIOVASCULAR-DISEASE; RENAL-FUNCTION; ACTIVITY
   THERMOGENESIS; BLOOD-PRESSURE; WEIGHT-LOSS; EXERCISE
AB Chronic kidney disease (CKD) is an important risk factor for cardiovascular disease (CVD) and mortality. The increase in CKD in recent decades has paralleled increases in obesity, diabetes, and the metabolic syndrome. Physical inactivity is a modifiable risk factor that may affect the development and course of CKD. It is well established that exercise training improves a number of metabolic factors, including blood pressure and insulin resistance, which would be expected to preserve renal function as well as lower CVD risk. Epidemiological studies have suggested that partaking in vigorous physical activity may protect against kidney disease. However, to date few studies have rigorously measured physical activity levels. Instead, investigators have relied on subjective measures of physical activity and patient recall. This is particularly problematic when attempting to capture low- and very-low-intensity physical activity and in quantifying sedentary behavior. Improvements in vascular endothelial function, insulin sensitivity, adipocytokine profiles, and oxidative stress likely mediate the benefits of physical activity on the kidney. While formal exercise recommendations have been published for diabetes and hypertension, guidelines regarding the optimal type, frequency, intensity and duration of physical activity for preventing CKD have yet to be formalized. Copyright (C) 2011 S. Karger AG, Basel
C1 [Stump, Craig S.] Univ Arizona, Sect Endocrinol Diabet & Hypertens, Dept Med, Tucson, AZ 85714 USA.
   [Stump, Craig S.] So Arizona VA Hlth Care Syst, Tucson, AZ USA.
C3 University of Arizona; US Department of Veterans Affairs; Veterans
   Health Administration (VHA); Southern Arizona Veterans Affairs Health
   Care System
RP Stump, CS (corresponding author), Univ Arizona, Sect Endocrinol Diabet & Hypertens, Dept Med, 3950 S Country Club Rd,Suite 200,Room 2221, Tucson, AZ 85714 USA.
EM cstump@deptofmed.arizona.edu
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NR 61
TC 48
Z9 58
U1 2
U2 15
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1664-3828
EI 1664-5502
J9 CARDIORENAL MED
JI CardioRenal Med.
PY 2011
VL 1
IS 3
BP 164
EP 173
DI 10.1159/000329929
PG 10
WC Cardiac & Cardiovascular Systems; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Urology & Nephrology
GA 051ZM
UT WOS:000312167500004
PM 22258539
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Alfeqy, MM
   El-Hawary, SS
   El-Halawany, AM
   Rabeh, MA
   Alshehri, SA
   Serry, AM
   Fahmy, HA
   Ezzat, MI
AF Alfeqy, Marwah M.
   El-Hawary, Seham S.
   El-Halawany, Ali M.
   Rabeh, Mohamed A.
   Alshehri, Saad A.
   Serry, Aya M.
   Fahmy, Heba A.
   Ezzat, Marwa. I.
TI Effect of Phenolics from Aeonium arboreum on Alpha Glucosidase,
   Pancreatic Lipase, and Oxidative Stress; a Bio-Guided Approach
SO PHARMACEUTICS
LA English
DT Article
DE Aeonium arboreum; metabolic syndrome; antioxidant; alpha-glucosidase;
   lipase
ID CHARANTIA BITTER-MELON; ANTIOXIDANT CAPACITY; INSULIN-RESISTANCE;
   INHIBITION; NANOFORMULATION; MECHANISMS; GLYCATION
AB Metabolic syndrome (MetS) is a global issue affecting over a billion people, raising the risk of diabetes, cardiovascular disorders, and other ailments. It is often characterized by hypertension, dyslipidemia and/or obesity, and hyperglycemia. Chemical investigation of Aeonium arboreum (L.) Webb & Berthel led to the isolation of six compounds, viz. beta-sitosterol, beta-sitosterol glucoside, myricetin galactoside, quercetin rhamnoside, kaempferol rhamnoside, and myricetin glucoside. Interestingly, A. arboreum's dichloromethane (DCM), 100 and 50% MeOH Diaion fractions and the isolated compound (quercetin-3-rhamnoside) revealed potent alpha-glucosidase inhibitory activity, especially 50% Diaion fraction. In addition, they also showed very potent antioxidant potential, especially the polar fractions, using DPPH, ABTS, FRAP, ORAC, and metal chelation assays. Notably, the 50% Diaion fraction had the highest antioxidant potential using DPPH and ORAC assays, while the 100% Diaion fraction and quercetin-3-rhamnoside showed the highest activity using ABTS, FRAP, and metal chelation assays. Also, quercetin-3-rhamnoside showed a good docking score of -5.82 kcal/mol in comparison to acarbose. In addition, molecular dynamic stimulation studies illustrated high stability of compound binding to pocket of protein. Such potent activities present A. arboreum as a complementary safe approach for the management of diabetes mellitus as well as MetS.
C1 [Alfeqy, Marwah M.; Fahmy, Heba A.] Modern Univ Technol & Informat, Fac Pharm, Pharmacognosy Dept, Cairo 11571, Egypt.
   [El-Hawary, Seham S.; El-Halawany, Ali M.; Ezzat, Marwa. I.] Cairo Univ, Fac Pharm, Pharmacognosy Dept, Cairo 11562, Egypt.
   [Rabeh, Mohamed A.; Alshehri, Saad A.] King Khalid Univ, Coll Pharm, Pharmacognosy Dept, Abha 62251, Saudi Arabia.
   [Serry, Aya M.] Modern Univ Technol & Informat, Fac Pharm, Pharmaceut Chem Dept, Cairo 11571, Egypt.
C3 Egyptian Knowledge Bank (EKB); Cairo University; King Khalid University
RP Alfeqy, MM (corresponding author), Modern Univ Technol & Informat, Fac Pharm, Pharmacognosy Dept, Cairo 11571, Egypt.; Ezzat, MI (corresponding author), Cairo Univ, Fac Pharm, Pharmacognosy Dept, Cairo 11562, Egypt.
EM drmarwahalfeqy@gmail.com; seham.elhawary@pharma.cu.edu.eg;
   ali.elhalawany@pharma.cu.edu.eg; mrabeh@kku.edu.sa; salshhri@kku.edu.sa;
   ayaserry@hotmail.com; heba.fahmy@pharm.mti.edu.eg;
   marwa.ezzat@pharma.cu.edu.eg
RI Alshehri, Saad/GQP-7813-2022; Ezzat, Marwa I./KFQ-3977-2024;
   El-Halawany, Ali/ABE-2550-2021
OI Fahmy, Heba/0000-0001-7359-2447
FU King Khalid University [RGP1/165/44]; Deanship of Scientific Research at
   King Khalid University; Drug Design at Faculty of Pharmacy, Egyptian
   Russian University
FX The authors extend their appreciation to the Deanship of Scientific
   Research at King Khalid University for funding this work through small
   group Research Project under grant number RGP1/165/44. The authors are
   also thankful to Mohamed Adel, the head of the Laboratory of Scientific
   Research and Drug Design at Faculty of Pharmacy, Egyptian Russian
   University.
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NR 50
TC 3
Z9 3
U1 1
U2 5
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1999-4923
J9 PHARMACEUTICS
JI Pharmaceutics
PD NOV
PY 2023
VL 15
IS 11
AR 2541
DI 10.3390/pharmaceutics15112541
PG 19
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA Z8ED7
UT WOS:001114343400001
PM 38004522
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Ferguson, M
   Vel, J
   Phan, V
   Ali, R
   Mabe, L
   Cherner, A
   Doan, T
   Manakatt, B
   Jose, M
   Powell, AR
   McKinney, K
   Serag, H
   Sallam, HS
AF Ferguson, Monique
   Vel, Jaysonn
   Phan, Vincent
   Ali, Roshaneh
   Mabe, Lainie
   Cherner, Annie
   Doan, Thao
   Manakatt, Bushra
   Jose, Mini
   Powell, Audrey Ross
   McKinney, Kevin
   Serag, Hani
   Sallam, Hanaa S.
TI Coronavirus Disease 2019, Diabetes, and Inflammation: A Systemic Review
SO METABOLIC SYNDROME AND RELATED DISORDERS
LA English
DT Review
DE COVID-19; SARS-CoV-2; type 2 diabetes; inflammation; obesity; metabolic
   syndrome
ID SARS-COV-2 INFECTION; COVID-19; HYPERGLYCEMIA; INDIVIDUALS; EXPRESSION;
   MORTALITY; OUTCOMES; TYPE-1
AB People with cardiometabolic diseases [namely type 2 diabetes (T2D), obesity, or metabolic syndrome] are more susceptible to coronavirus disease 2019 (COVID-19) infection and endure more severe illness and poorer outcomes. Hyperinflammation has been suggested as a common pathway for both diseases. To examine the role of inflammatory biomarkers shared between COVID-19 and cardiometabolic diseases, we reviewed and evaluated published data using PubMed, SCOPUS, and World Health Organization COVID-19 databases for English articles from December 2019 to February 2022. Of 248 identified articles, 50 were selected and included. We found that people with diabetes or obesity have (i) increased risk of COVID-19 infection; (ii) increased risk of hospitalization (those with diabetes have a higher risk of intensive care unit admissions) and death; and (iii) heightened inflammatory and stress responses (hyperinflammation) to COVID-19, which worsen their prognosis. In addition, COVID-19-infected patients have a higher risk of developing T2D, especially if they have other comorbidities. Treatments controlling blood glucose levels and or ameliorating the inflammatory response may be valuable for improving clinical outcomes in these patient populations. In conclusion, it is critical for health care providers to clinically evaluate hyperinflammatory states to drive clinical decisions for COVID-19 patients.
C1 [Ferguson, Monique; Vel, Jaysonn; Phan, Vincent; Ali, Roshaneh; Mabe, Lainie; Cherner, Annie; Doan, Thao; McKinney, Kevin; Serag, Hani; Sallam, Hanaa S.] Univ Texas Med Branch, John Sealy Sch Med, Galveston, TX USA.
   [Ferguson, Monique; McKinney, Kevin; Serag, Hani; Sallam, Hanaa S.] Univ Texas Med Branch, Dept Internal Med, Galveston, TX USA.
   [Powell, Audrey Ross] Univ Texas Med Branch Alumni, Galveston, TX USA.
   [Manakatt, Bushra; Jose, Mini] Univ Texas Med Branch, Sch Nursing, Galveston, TX USA.
   [Powell, Audrey Ross] Madrigal Pharmaceut, Conshohocken, PA USA.
   [Sallam, Hanaa S.] Suez Canal Univ, Fac Med, Physiol Dept, Ismailia, Egypt.
   [Sallam, Hanaa S.] Univ Texas Med Branch, Dept Internal Med, 301 Univ Blvd,MRB,Room 8 162, Galveston, TX 77555 USA.
C3 University of Texas System; University of Texas Medical Branch
   Galveston; University of Texas System; University of Texas Medical
   Branch Galveston; University of Texas System; University of Texas
   Medical Branch Galveston; Egyptian Knowledge Bank (EKB); Suez Canal
   University; University of Texas System; University of Texas Medical
   Branch Galveston
RP Sallam, HS (corresponding author), Univ Texas Med Branch, Dept Internal Med, 301 Univ Blvd,MRB,Room 8 162, Galveston, TX 77555 USA.
EM hssallam@utmb.edu
RI Sallam, Hanaa/ABD-7361-2020
OI MANAKATT, BUSHRA/0000-0002-9981-5781
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NR 82
TC 5
Z9 5
U1 0
U2 6
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-4196
EI 1557-8518
J9 METAB SYNDR RELAT D
JI Metab. Syndr. Relat. Disord.
PD MAY 1
PY 2023
VL 21
IS 4
BP 177
EP 187
DI 10.1089/met.2022.0090
EA MAY 2023
PG 11
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA AU6K0
UT WOS:000979150900001
PM 37130311
OA hybrid
DA 2025-06-11
ER

PT J
AU Kowalska, K
   Olejnik, A
AF Kowalska, Katarzyna
   Olejnik, Anna
TI Current evidence on the health-beneficial effects of berry fruits in the
   prevention and treatment of metabolic syndrome
SO CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE
LA English
DT Review
DE berries; metabolic disorders; prevention
ID RANDOMIZED CONTROLLED-TRIAL; OXIDATIVE STRESS MARKERS; HEPATIC
   GENE-EXPRESSION; RICH CHOKEBERRY JUICE; C-REACTIVE PROTEIN;
   BLOOD-PRESSURE; BLACK-CURRANT; CRANBERRY JUICE; HIGH-FAT; ARTERIAL
   STIFFNESS
AB Purpose of reviewBerries belong to the best dietary sources of bioactive compounds, which exert a synergistic and cumulative effect on promotion of human health and prevention of diseases. The present review presents the most recent findings of animal and human studies regarding the health benefits of berries in terms of prevention and treatment of obesity, hypertension, type 2 diabetes, dyslipidemia, and nonalcoholic fatty liver disease.Recent findingsIn the last years, there was a growing number of evidence from human epidemiological and interventional studies, which emphasized the role of berries in the management of metabolic diseases. Based on the results from recent clinical trials, it can be established that a berry diet rich in antioxidants and bioactive phytochemicals has beneficial effects on hepatic function, increase of insulin sensitivity and high-density lipoprotein-cholesterol, decrease of serum glucose and low-density lipoprotein-cholesterol, and finally is inversely associated with the incidence of type 2 diabetes.SummaryNumerous recent studies have shown that berries provide great benefits in preventing or mitigating metabolic disorders. The results of this review indicate that regular long-term consumption of different berries could potentially delay the progression of metabolic syndrome and comorbidities.
C1 [Kowalska, Katarzyna; Olejnik, Anna] Poznan Univ Life Sci, Dept Biotechnol & Food Microbiol, Wojska Polskiego 48, PL-60627 Poznan, Poland.
C3 Poznan University of Life Sciences
RP Kowalska, K (corresponding author), Poznan Univ Life Sci, Dept Biotechnol & Food Microbiol, Wojska Polskiego 48, PL-60627 Poznan, Poland.
EM kaskakow@up.poznan.pl
RI Kowalska, Katarzyna/AAC-7968-2021
OI Kowalska, Katarzyna/0000-0001-7706-4035; Olejnik,
   Anna/0000-0002-4385-0051
FU National Science Centre, Poland [2015/19/B/NZ9/01054]
FX This work was supported by the National Science Centre, Poland (Grant
   No. 2015/19/B/NZ9/01054).
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NR 48
TC 32
Z9 34
U1 2
U2 42
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1363-1950
EI 1473-6519
J9 CURR OPIN CLIN NUTR
JI Curr. Opin. Clin. Nutr. Metab. Care
PD NOV
PY 2016
VL 19
IS 6
BP 446
EP 452
DI 10.1097/MCO.0000000000000322
PG 7
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA EA1IN
UT WOS:000386345800007
PM 27583706
DA 2025-06-11
ER

PT J
AU He, Z
   Li, J
   Luo, HW
   Zhang, L
   Ma, L
   Chen, LB
   Wang, H
AF He, Zheng
   Li, Jing
   Luo, Hanwen
   Zhang, Li
   Ma, Lu
   Chen, Liaobin
   Wang, Hui
TI Sex-specific increase in susceptibility to metabolic syndrome in adult
   offspring after prenatal ethanol exposure with post-weaning high-fat
   diet
SO SCIENTIFIC REPORTS
LA English
DT Article
ID PITUITARY-ADRENAL AXIS; ALCOHOL EXPOSURE; PERINATAL OUTCOMES;
   INSULIN-RESISTANCE; GROWTH RESTRICTION; GLUCOSE-TOLERANCE; OXIDATIVE
   STRESS; CHILDREN; OBESITY; LIVER
AB Prenatal ethanol exposure (PEE) is an established risk factor for intrauterine growth retardation. The present study was designed to determine whether PEE can increase the susceptibility of highfat diet (HFD)-induced metabolic syndrome (MS) in adult offspring in a sex-specific manner, based on a generalized linear model analysis. Pregnant Wistar rats were administered ethanol (4 g/kg. d) from gestational day 11 until term delivery. All offspring were fed either a normal diet or a HFD after weaning and were sacrificed at postnatal week 20, and blood samples were collected. Results showed that PEE reduced serum adrenocorticotropic hormone (ACTH) and corticosterone levels but enhanced serum glucose, insulin, insulin resistant index (IRI), triglyceride and total cholesterol (TC) concentrations. Moreover, the analysis showed interactions among PEE, HFD and sex. In the PEE offspring, HFD aggravated the decrease in ACTH and corticosterone levels and further increased serum glucose, insulin, triglyceride and TC levels. The changes of serum ACTH, glucose and IRI levels in the female HFD rats were greater than those in the male HFD rats. Our findings suggest that PEE enhances the susceptibility to MS induced by HFD in a sex-specific manner, which might be primarily associated with the neuroendocrine metabolic programming by PEE.
C1 [He, Zheng; Li, Jing; Zhang, Li; Wang, Hui] Wuhan Univ, Basic Med Sch, Dept Pharmacol, Wuhan 430071, Peoples R China.
   [Luo, Hanwen; Chen, Liaobin] Wuhan Univ, Zhongnan Hosp, Dept Orthoped Surg, Wuhan 430071, Peoples R China.
   [Wang, Hui] Hubei Prov Key Lab Dev Originated Dis, Wuhan 430071, Peoples R China.
   [Ma, Lu] Wuhan Univ, Sch Publ Hlth, Dept Epidemiol & Hlth Stat, Wuhan 430071, Peoples R China.
C3 Wuhan University; Wuhan University; Wuhan University
RP Wang, H (corresponding author), Wuhan Univ, Basic Med Sch, Dept Pharmacol, Wuhan 430071, Peoples R China.
EM wanghui19@whu.edu.cn
FU National Science & Technology Pillar Program of China [2013BAI12B01-3];
   National Natural Science Foundation of China [81220108026, 81430089,
   30830112, 81072709]
FX This work was supported by grants from the National Science & Technology
   Pillar Program of China (No. 2013BAI12B01-3), and National Natural
   Science Foundation of China (Nos 81220108026, 81430089, 30830112,
   81072709).
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NR 52
TC 14
Z9 15
U1 0
U2 13
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD DEC 3
PY 2015
VL 5
AR 17679
DI 10.1038/srep17679
PG 10
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA CX4WX
UT WOS:000365702200001
PM 26631430
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Thomson, RL
   Buckley, JD
   Brinkworth, GD
AF Thomson, Rebecca L.
   Buckley, Jonathan D.
   Brinkworth, Grant D.
TI Perceived exercise barriers are reduced and benefits are improved with
   lifestyle modification in overweight and obese women with polycystic
   ovary syndrome: a randomised controlled trial
SO BMC WOMENS HEALTH
LA English
DT Article
DE Weight loss; PCOS; Aerobic training; Resistance training; Diet
ID PHYSICAL-ACTIVITY; DIAGNOSTIC-CRITERIA; CARDIOMETABOLIC RISK; REPORTED
   EXERCISE; SYNDROME PCOS; HEALTH; PREVALENCE; MODEL
AB Background: This study assessed the perceived benefits and barriers to exercise participation in overweight and obese women with polycystic ovary syndrome (PCOS) and monitored changes in response to a lifestyle intervention.
   Methods: Forty-three overweight/obese PCOS women (Age, 30.3(6.2) yrs; BMI, 36.4(5.6) kg/m(2)) were randomised to one of three 20-week lifestyle programs: diet only (DO, n = 13), diet and aerobic exercise (DA, n = 11) and diet and combined aerobic-resistance exercise (DC, n = 19). Exercise Benefits/Barriers Scale (EBBS), weight, aerobic fitness, depression and PCOS specific health-related quality of life were measured.
   Results: Barriers score was related to depression (r = 0.45, P = 0.002) and aerobic fitness (r = -0.32, P = 0.04), while benefits score was related to aerobic fitness (r = 0.41, P = 0.007). EBBS, benefits and barriers scores improved overtime (P = 0.001). Benefits subscales psychological outlook and social interaction increased (P = 0.001) and life enhancement and preventative health did not change (P = 0.3). Physical performance increased only in DA (P = 0.009). There were no differences between treatments for any of the other subscales (P = 0.2). Barriers subscales exercise milieu, time expenditure and physical exertion reduced (P = 0.003) and family discouragement did not change (P = 0.6).
   Conclusions: This study demonstrated that lifestyle modification consisting of an energy-restricted diet with or without exercise training improved the perceived benefits from and barriers to exercise.
C1 [Thomson, Rebecca L.; Buckley, Jonathan D.] Univ S Australia, Sansom Inst Hlth Res, ARENA, Adelaide, SA 5001, Australia.
   [Brinkworth, Grant D.] CSIRO, Food & Nutr Flagship, Food & Nutr Sci, Adelaide, SA 5000, Australia.
C3 University of South Australia; Commonwealth Scientific & Industrial
   Research Organisation (CSIRO)
RP Thomson, RL (corresponding author), Univ S Australia, Sansom Inst Hlth Res, ARENA, Adelaide, SA 5001, Australia.
EM rebecca.thomson@unisa.edu.au
RI Buckley, Jonathan/B-7830-2009; Brinkworth, Grant/H-2815-2013; Thomson,
   Rebecca/AAL-8597-2021; Thomson, Rebecca/B-7831-2009
OI Buckley, Jonathan/0000-0003-0298-2186; Thomson,
   Rebecca/0000-0002-7807-4144; Brinkworth, Grant/0000-0001-9017-8395
FU National Health and Medical Research Council of Australia [401817];
   South Australia Department of Health
FX We gratefully acknowledge Manny Noakes, Peter Clifton and Robert Norman
   for their input with study design and acquiring funding, Julia Weaver
   for assisting with trial management, Lindy Lawson and Rosemary McArthur
   for their assistance in the nursing activities, and Gemma Williams,
   Xenia Cleanthous and Julianne McKeough for their dietetic guidance. This
   project was funded by a grant from the National Health and Medical
   Research Council of Australia (401817). Rebecca Thomson was funded by a
   postgraduate scholarship from the South Australia Department of Health.
   The funding sources had no role in study design, data collection and
   analysis, decision to publish, or preparation of the manuscript.
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NR 25
TC 34
Z9 39
U1 3
U2 22
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1472-6874
J9 BMC WOMENS HEALTH
JI BMC Womens Health
PD MAR 9
PY 2016
VL 16
AR 14
DI 10.1186/s12905-016-0292-8
PG 9
WC Public, Environmental & Occupational Health; Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; Obstetrics & Gynecology
GA DG3NK
UT WOS:000371976200001
PM 26960762
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Henley, P
   Jahedmotlagh, Z
   Thomson, S
   Hill, J
   Darnell, R
   Jacobs, D
   Johnson, J
   Williams, NC
   Williams, RM
   Van Uum, S
   Bend, JR
   Koren, G
AF Henley, Phaedra
   Jahedmotlagh, Zahra
   Thomson, Steven
   Hill, Julie
   Darnell, Regna
   Jacobs, Dean
   Johnson, Joyce
   Williams, Naomi C.
   Williams, Rosemary M.
   Van Uum, Stan
   Bend, John R.
   Koren, Gideon
TI Hair Cortisol as a Biomarker of Stress Among a First Nation in Canada
SO THERAPEUTIC DRUG MONITORING
LA English
DT Article
DE First Nations; cortisol; chronic stress; hair; diabetes mellitus;
   smoking
ID PITUITARY-ADRENAL AXIS; METABOLIC SYNDROME; PERCEIVED DISCRIMINATION;
   SOCIOECONOMIC-STATUS; DRUG INCORPORATION; ABORIGINAL HEALTH; HABITUAL
   SMOKERS; SMOKING; NICOTINE; MECHANISMS
AB Background:Cortisol level in hair is increasingly being used as a biomarker of chronic stress. Members of First Nation communities in Canada are experiencing stress related to a higher incidence of chronic diseases, socioeconomic factors, the state of their environment, and cultural oppression. This study aimed to investigate hair cortisol as a biomarker of stress in this population.Materials and Methods:Hair samples were collected from the posterior vertex of 55 Walpole Island First Nation (WIFN) volunteers and compared with white volunteers living in and around London, ON, Canada. An enzyme-linked immunosorbent assay technique was used to measure cortisol content in 1 cm of hair, considered to represent 1 month of growth. In parallel, the Perceived Stress Scale (PSS), which measures short-term stress, was also completed.Results:Median hair cortisol level (range) in WIFN volunteers was 177 (93-273) ng/g, significantly higher than the median hair cortisol in the healthy white controls of 116 (26-204) ng/g (P < 0.0001, Mann-Whitney U test). Hair cortisol correlated positively with gender, smoking status, and self-reported diabetes. Unlike hair cortisol, the Perceived Stress Scale did not differentiate between the First Nation and control population.Conclusions:The increased hair cortisol concentrations among WIFN volunteers compared with volunteers from a non-First Nation community suggests higher levels of chronic stress. The causes for this apparent increased stress are likely due to factors such as socioeconomic and poorer health and are worthy of further evaluation. The results highlight the difference between acute stress measured for short periods of time compared with chronic stress, measured by hair analysis.
C1 [Henley, Phaedra; Jahedmotlagh, Zahra; Hill, Julie; Darnell, Regna; Bend, John R.; Koren, Gideon] Univ Western Ontario, Ecosyst Hlth Res Program, London, ON N6A 3K7, Canada.
   [Henley, Phaedra; Jahedmotlagh, Zahra; Darnell, Regna; Bend, John R.] Univ Western Ontario, Dept Pathol, London, ON N6A 3K7, Canada.
   [Henley, Phaedra; Jahedmotlagh, Zahra; Thomson, Steven; Hill, Julie; Van Uum, Stan; Koren, Gideon] Univ Western Ontario, Ivey Chair Mol Toxicol, London, ON N6A 3K7, Canada.
   [Thomson, Steven; Hill, Julie; Bend, John R.; Koren, Gideon] Univ Western Ontario, Dept Physiol & Pharmacol, London, ON N6A 3K7, Canada.
   [Darnell, Regna] Univ Western Ontario, Dept Anthropol, London, ON N6A 3K7, Canada.
   [Jacobs, Dean; Johnson, Joyce; Williams, Naomi C.] Walpole Isl First Nation Heritage Ctr, Toronto, ON, Canada.
   [Williams, Rosemary M.] Ctr Hlth, Toronto, ON, Canada.
   [Van Uum, Stan] Univ Western Ontario, Div Endocrinol, London, ON N6A 3K7, Canada.
   [Bend, John R.; Koren, Gideon] Univ Western Ontario, Dept Pediat, London, ON N6A 3K7, Canada.
   [Koren, Gideon] Univ Western Ontario, Dept Med, London, ON N6A 3K7, Canada.
   [Koren, Gideon] Univ Toronto, Motherisk Program, Hosp Sick Children, Toronto, ON M5S 1A1, Canada.
   [Koren, Gideon] Univ Toronto, Div Clin Pharmacol, Hosp Sick Children, Toronto, ON M5S 1A1, Canada.
C3 Western University (University of Western Ontario); Western University
   (University of Western Ontario); Western University (University of
   Western Ontario); Western University (University of Western Ontario);
   Western University (University of Western Ontario); Western University
   (University of Western Ontario); Western University (University of
   Western Ontario); Western University (University of Western Ontario);
   University of Toronto; Hospital for Sick Children (SickKids); University
   of Toronto; Hospital for Sick Children (SickKids)
RP Henley, P (corresponding author), Univ Western Ontario, Schulich Sch Med & Dent, Dent Sci Bldg,Room 4037, London, ON N6A 3K7, Canada.
EM dhenley@uwo.ca
RI van Uum, Stan/G-3351-2011; Bend, John/AFO-2623-2022
FU Health Canada National First Nations Environmental Contaminants Program
FX Supported by Health Canada National First Nations Environmental
   Contaminants Program.
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NR 71
TC 28
Z9 33
U1 0
U2 40
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0163-4356
EI 1536-3694
J9 THER DRUG MONIT
JI Ther. Drug Monit.
PD OCT
PY 2013
VL 35
IS 5
BP 595
EP 599
DI 10.1097/FTD.0b013e318292eb84
PG 5
WC Medical Laboratory Technology; Pharmacology & Pharmacy; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology; Pharmacology & Pharmacy; Toxicology
GA 224LP
UT WOS:000324887600005
PM 24052063
DA 2025-06-11
ER

PT J
AU Dornas, WC
   de Lima, WG
   Pedrosa, ML
   Silva, ME
AF Dornas, Waleska C.
   de Lima, Wanderson G.
   Pedrosa, Maria L.
   Silva, Marcelo E.
TI Health Implications of High-Fructose Intake and Current Research
SO ADVANCES IN NUTRITION
LA English
DT Review
DE antioxidants; fructose; hypertension; oxidative stress; sugar-sweetened
   beverages
ID SERUM URIC-ACID; TRIGLYCERIDE TRANSFER PROTEIN; SKELETAL-MUSCLE
   VASODILATION; INDUCED INSULIN-RESISTANCE; INDUCED METABOLIC SYNDROME;
   NITRIC-OXIDE SYNTHASE; FATTY LIVER-DISEASE; DIETARY FRUCTOSE;
   ENDOTHELIAL DYSFUNCTION; SWEETENED BEVERAGES
AB Although fructose consumption has dramatically increased and is suspected to be causally linked to metabolic abnormalities, the mechanisms involved are still only partially understood. We discuss the available data and investigate the effects of dietary fructose on risk factors associated with metabolic disorders. The evidence suggests that fructose may be a predisposing cause in the development of insulin resistance in association with the induction of hypertriglyceridemia. Experiments in animals have shown this relation when they are fed diets very high in fructose or sucrose, and human studies also show this relation, although with conflicting results due to the heterogeneity of the studies. The link between increased fructose consumption and increases in uric acid also has been confirmed as a potential risk factor for metabolic syndrome, and insulin resistance/hyperinsulinemia may be causally related to the development of hypertension. Collectively, these results suggest a link between high fructose intake and insulin resistance, although future studies must be of reasonable duration, use defined populations, and improve comparisons regarding the effects of relevant doses of nutrients on specific endpoints to fully understand the effect of fructose intake in the absence of potential confounding factors.
C1 [Dornas, Waleska C.; de Lima, Wanderson G.; Pedrosa, Maria L.; Silva, Marcelo E.] Univ Fed Ouro Preto, Res Biol Sci Ctr Res Biol Sci NUPEB, Ouro Preto, MG, Brazil.
   [de Lima, Wanderson G.; Pedrosa, Maria L.] Univ Fed Ouro Preto, Dept Biol Sci, Inst Exact & Biol Sci, Ouro Preto, MG, Brazil.
   [Silva, Marcelo E.] Univ Fed Ouro Preto, Dept Foods, Sch Nutr, Ouro Preto, MG, Brazil.
C3 Universidade Federal de Ouro Preto; Universidade Federal de Ouro Preto;
   Universidade Federal de Ouro Preto
RP Dornas, WC (corresponding author), Univ Fed Ouro Preto, Res Biol Sci Ctr Res Biol Sci NUPEB, Ouro Preto, MG, Brazil.
EM w.dornas@ig.com.br
RI Dornas, Waleska/AAH-5934-2020; Silva, Maria/JXM-0158-2024; Lima,
   Wanderson/Y-7198-2019
OI Lima, Wanderson/0000-0001-9844-3472
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NR 103
TC 71
Z9 77
U1 0
U2 37
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 2161-8313
EI 2156-5376
J9 ADV NUTR
JI Adv. Nutr.
PD NOV
PY 2015
VL 6
IS 6
BP 729
EP 737
DI 10.3945/an.114.008144
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA CV8ZQ
UT WOS:000364577400010
PM 26567197
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Alam, MA
   Kauter, K
   Brown, L
AF Alam, Md. Ashraful
   Kauter, Kathleen
   Brown, Lindsay
TI Naringin Improves Diet-Induced Cardiovascular Dysfunction and Obesity in
   High Carbohydrate, High Fat Diet-Fed Rats
SO NUTRIENTS
LA English
DT Article
DE naringin; obesity; hypertension; inflammation; mitochondria
ID INDUCED MYOCARDIAL-INFARCTION; INDUCED METABOLIC SYNDROME; CITRUS
   FLAVONOIDS; WISTAR RATS; REGULATING ENZYMES; LIPID PEROXIDES; IN-VIVO;
   HESPERIDIN; CHOLESTEROL; FLAVANONES
AB Obesity, insulin resistance, hypertension and fatty liver, together termed metabolic syndrome, are key risk factors for cardiovascular disease. Chronic feeding of a diet high in saturated fats and simple sugars, such as fructose and glucose, induces these changes in rats. Naturally occurring compounds could be a cost-effective intervention to reverse these changes. Flavonoids are ubiquitous secondary plant metabolites; naringin gives the bitter taste to grapefruit. This study has evaluated the effect of naringin on diet-induced obesity and cardiovascular dysfunction in high carbohydrate, high fat-fed rats. These rats developed increased body weight, glucose intolerance, increased plasma lipid concentrations, hypertension, left ventricular hypertrophy and fibrosis, liver inflammation and steatosis with compromised mitochondrial respiratory chain activity. Dietary supplementation with naringin (approximately 100 mg/kg/day) improved glucose intolerance and liver mitochondrial dysfunction, lowered plasma lipid concentrations and improved the structure and function of the heart and liver without decreasing total body weight. Naringin normalised systolic blood pressure and improved vascular dysfunction and ventricular diastolic dysfunction in high carbohydrate, high fat-fed rats. These beneficial effects of naringin may be mediated by reduced inflammatory cell infiltration, reduced oxidative stress, lowered plasma lipid concentrations and improved liver mitochondrial function in rats.
C1 [Alam, Md. Ashraful] Univ Queensland, Sch Biomed Sci, Brisbane, Qld 4072, Australia.
   [Kauter, Kathleen; Brown, Lindsay] Univ So Queensland, Dept Biol & Phys Sci, Toowoomba, Qld 4350, Australia.
C3 University of Queensland; University of Southern Queensland
RP Brown, L (corresponding author), Univ Queensland, Sch Biomed Sci, Brisbane, Qld 4072, Australia.
EM sonaliagun@yahoo.com; Kate.Kauter@usq.edu.au; Lindsay.Brown@usq.edu.au
RI Alam, Ashraful/G-1964-2014
OI Alam, Md Ashraful/0000-0001-7596-5868; Kauter, Kate/0000-0003-2470-9172
FU Islamic Development Bank, Jeddah, Saudi Arabia; UQIRTA from University
   of Queensland
FX MAA was supported by a Merit Development Scholarship from the Islamic
   Development Bank, Jeddah, Saudi Arabia, and UQIRTA from The University
   of Queensland. We thank Brian Bynon, School of Veterinary Science, and
   Paul Addison, School of Biomedical Sciences, both at The University of
   Queensland, for their help with plasma biochemical analyses and
   histology, respectively. We also thank Jason Brightwell, The Prince
   Charles Hospital, Brisbane, for the acquisition of the echocardiographic
   images.
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NR 41
TC 150
Z9 162
U1 1
U2 65
PU MDPI AG
PI BASEL
PA POSTFACH, CH-4005 BASEL, SWITZERLAND
SN 2072-6643
J9 NUTRIENTS
JI Nutrients
PD MAR
PY 2013
VL 5
IS 3
BP 637
EP 650
DI 10.3390/nu5030637
PG 14
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 112RM
UT WOS:000316610400002
PM 23446977
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Husain, S
   Hillmann, K
   Hengst, K
   Englert, H
AF Husain, Sarah
   Hillmann, Katharina
   Hengst, Karin
   Englert, Heike
TI Effects of a lifestyle intervention on the biomarkers of oxidative
   stress in non-communicable diseases: A systematic review
SO FRONTIERS IN AGING
LA English
DT Review
DE oxidative stress; lifestyle intervention; lifestyle diseases;
   antioxidants; non-communicable diseases; prevention; ageing; immunity
ID GLYCATION END-PRODUCTS; METABOLIC SYNDROME; LIPID-PEROXIDATION;
   WEIGHT-LOSS; ANTIOXIDANT; VEGETABLES; MARKERS; DIET; GLUTATHIONE;
   PROFILE
AB Oxidative stress plays a critical role in the pathogenesis of chronic diseases. Therefore, improvement of oxidative stress status through lifestyle intervention can play a vital role in preventing and treating chronic diseases. This systematic review aims to provide an overview of articles published in the last decade examining the association between lifestyle intervention and oxidative stress biomarkers in the context of non-communicable diseases. The electronic databases PubMed and Web of Science were searched for relevant studies, following the PRISMA (Preferred Reporting of Systematic Reviews and Meta-Analyses) guidelines. This systematic review focused on the four important oxidative stress biomarkers; glutathione (GSH), superoxide dismutase (SOD), catalase, and malondialdehyde. 671 articles were identified, of which nine met the inclusion criteria. A trend emerged, showing that lifestyle modifications that focus on diet and physical health can improve oxidative stress in the form of an increase in superoxide dismutase and CAT levels and a decrease in Malondialdehyde levels in participants with non-communicable diseases (NCDs), GSH levels were not affected. However, the results are difficult to compare because of the heterogeneity of the methods of the biomarkers studied. Our review indicates that oxidative stress can be influenced by lifestyle modifications and may be an effective tool for the prevention and management of non-communicable diseases. This review also elucidated the importance of analyzing multiple oxidative stress biomarkers to evaluate oxidative stress, it further highlights the need to conduct long-term lifestyle intervention studies on oxidative stress biomarkers to understand the connection between oxidative stress biomarkers, NCDs and Lifestyle intervention.
C1 [Husain, Sarah; Hillmann, Katharina; Englert, Heike] Univ Muenster WWU, Fac Med, Munster, Germany.
   [Husain, Sarah; Englert, Heike] Univ Appl Sci Muenster, Dept Food Nutr & Facil, Munster, Germany.
   [Hengst, Karin] Univ Hosp Muenster UKM, Dept Med, Munster, Germany.
C3 University of Applied Sciences, Muenster
RP Husain, S (corresponding author), Univ Muenster WWU, Fac Med, Munster, Germany.; Husain, S (corresponding author), Univ Appl Sci Muenster, Dept Food Nutr & Facil, Munster, Germany.
EM shusain@uni-muenster.de
RI Husain, Sarah/NBX-6933-2025
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NR 70
TC 19
Z9 19
U1 3
U2 10
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 2673-6217
J9 FRONT AGING-LAUSANNE
JI Front. Aging
PD MAR 9
PY 2023
VL 4
AR 1085511
DI 10.3389/fragi.2023.1085511
PG 12
WC Geriatrics & Gerontology
WE Emerging Sources Citation Index (ESCI)
SC Geriatrics & Gerontology
GA U9FF7
UT WOS:001087781300001
PM 36970730
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Haley, S
   Neff, K
   Gulliver, K
   Gough, G
   Slater, H
   Lane, RH
   Moyer-Mileur, LJ
AF Haley, Shannon
   Neff, Kimberly
   Gulliver, Kristina
   Gough, Grace
   Slater, Hillarie
   Lane, Robert H.
   Moyer-Mileur, Laurie J.
TI Mechanical-tactile stimulation (MTS) intervention in a neonatal stress
   model alters adult adipose tissue deposition and prevents
   hyperinsulinemia in male rats
SO EARLY HUMAN DEVELOPMENT
LA English
DT Article
DE Mechanical-tactile stimulation; Adipose tissue; Adiponectin; Leptin
ID FATTY-ACID OXIDATION; IGF-I; BRAIN-DEVELOPMENT; PRETERM INFANTS;
   ADIPONECTIN; LEPTIN; GROWTH; MASSAGE; INSULIN; HYPERGLYCEMIA
AB Preterm infants are exposed to numerous stressors during hospitalization and by term corrected gestational age they have lower body weight but a greater proportion of total body as well as abdominal visceral adipose tissue (VAT) accumulation. Greater abdominal VAT stores have a known association with metabolic syndrome. Mechanical-tactile stimulation (MTS) improves modulation of stress response in both humans and rodents. We hypothesize that MTS, administered during an established model of neonatal stress, would decrease stress-driven adiposity and prevent associated metabolic imbalances in adult rats. Neonatal stress, administered to rat pups from postnatal days 5 to P9, consisted of needle puncture and hypoxic/hyperoxic challenge during 60 min of maternal separation (STRESS; n = 20). Mechanical-tactile stimulation (MTS; n = 20) was administered to rat pups for 10 min during maternal separation in the stress protocol. Control animals received standard care (CTL; n = 20). MRI measured adult (P120) abdominal total fat mass, subcutaneous (SAT) and visceral adipose tissue (VAT). Body weight and fasting serum adiponectin, leptin, glucose, insulin, and corticosterone were also measured. STRESS results in elevated VAT/SAT ratio compared to CTL but lower abdominal total fat mass and abdominal SAT. STRESS males experience hyperinsulinemia. Both STRESS and MTS had elevated leptin with lower adiponectin and corticosterone compared to CTL. In summary, neonatal stress promotes greater abdominal VAT accumulation and, in males, caused hyperinsulinemia and hypoadiponectinemia. Importantly, MTS normalized the VAT/SAT ratio and prevented hyperinsulinemia. We speculate that MTS ameliorates some of the negative metabolic consequences of early life perturbations due to neonatal stress exposure. (c) 2012 Elsevier Ireland Ltd. All rights reserved.
C1 [Haley, Shannon; Neff, Kimberly; Gulliver, Kristina; Gough, Grace; Slater, Hillarie; Moyer-Mileur, Laurie J.] Univ Utah, Ctr Pediat Nutr Res, Salt Lake City, UT 84108 USA.
   [Lane, Robert H.] Univ Utah, Sch Med, Salt Lake City, UT 84108 USA.
C3 Utah System of Higher Education; University of Utah; Utah System of
   Higher Education; University of Utah
RP Haley, S (corresponding author), Univ Utah, Dept Pediat, Ctr Pediat Nutr Res, POB 581289, Salt Lake City, UT 84108 USA.
EM shannon.haley@hsc.utah.edu
FU National Institutes of Health National Center for Complementary and
   Alternative Medicine [F32AT005568]
FX Shannon Haley is supported by the National Institutes of Health National
   Center for Complementary and Alternative Medicine (F32AT005568). We
   thank the Developmental Origins of Disease Laboratories for their help
   with MTS treatments and harvests.
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NR 48
TC 10
Z9 10
U1 0
U2 6
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0378-3782
EI 1872-6232
J9 EARLY HUM DEV
JI Early Hum. Dev.
PD JUN
PY 2013
VL 89
IS 6
BP 387
EP 392
DI 10.1016/j.earlhumdev.2012.12.005
PG 6
WC Obstetrics & Gynecology; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology; Pediatrics
GA 143SY
UT WOS:000318889700004
PM 23290636
DA 2025-06-11
ER

PT J
AU Macedo, IC
   Medeiros, LF
   Oliveira, C
   Oliveira, CM
   Rozisky, JR
   Scarabelot, VL
   Souza, A
   Silva, FR
   Santos, VS
   Cioato, SG
   Caumo, W
   Torres, ILS
AF Macedo, I. C.
   Medeiros, L. F.
   Oliveira, C.
   Oliveira, C. M.
   Rozisky, J. R.
   Scarabelot, V. L.
   Souza, A.
   Silva, F. R.
   Santos, V. S.
   Cioato, S. G.
   Caumo, W.
   Torres, I. L. S.
TI Cafeteria diet-induced obesity plus chronic stress alter serum leptin
   levels
SO PEPTIDES
LA English
DT Article
DE Adipose tissue; Cafeteria diet; Chronic restraint stress; Hypercaloric
   diet; Leptin; Obesity
ID HIGH-FAT DIET; CHRONIC SOCIAL STRESS; NEUROPEPTIDE-Y; BODY-WEIGHT;
   FEEDING-BEHAVIOR; RESTRAINT STRESS; METABOLIC SYNDROME; EATING BEHAVIOR;
   ADIPOSE-TISSUE; CARDIOVASCULAR-DISEASES
AB Obesity is a disease that has become a serious public health issue worldwide, and chronic stressors, which are a problem for modern society, cause neuroendocrine changes with alterations in food intake. Obesity and chronic stress are associated with the development of cardiovascular diseases and metabolic disorders. In this study, a rat model was used to evaluate the effects of a hypercaloric diet plus chronic restraint stress on the serum leptin and lipids levels and on the weight of specific adipose tissue (mesenteric, MAT; subcutaneous, SAT and visceral, VAT). Wistar rats were divided into the following 4 groups: standard chow (C), hypercaloric diet (HD), stress plus standard chow (S), and stress plus hypercaloric diet (SHD). The animals in the stress groups were subjected to chronic stress (placed inside a 25 cm x 7 cm plastic tube for 1 h per day, 5 days per week for 6 weeks). The following parameters were evaluated: the weight of the liver, adrenal glands and specific adipose tissue; the delta weight; the Lee index; and the serum levels of leptin, corticosterone, glucose, total cholesterol, and triglycerides. The hypercaloric diet induced obesity in rats, increasing the Lee index, weight, leptin, triglycerides, and cholesterol levels. The stress decreased weight gain even in animals fed a hypercaloric diet but did not prevent a significant increase in the Lee index. However, an interaction between the independent factors (hypercaloric diet and stress) was observed, which is demonstrated by the increased serum leptin levels in the animals exposed to both protocols. (C) 2012 Elsevier Inc. All rights reserved.
C1 [Macedo, I. C.; Medeiros, L. F.; Oliveira, C.; Oliveira, C. M.; Rozisky, J. R.; Scarabelot, V. L.; Souza, A.; Silva, F. R.; Santos, V. S.; Cioato, S. G.; Torres, I. L. S.] Univ Fed Rio Grande do Sul, Inst Ciencias Basicas Saude, Dept Farmacol, Pain Pharmacol Lab, BR-90050170 Porto Alegre, RS, Brazil.
   [Macedo, I. C.; Medeiros, L. F.; Scarabelot, V. L.; Torres, I. L. S.] Univ Fed Rio Grande do Sul, Inst Ciencias Basicas Saude, Grad Program Biol Sci Physiol, BR-90050170 Porto Alegre, RS, Brazil.
   [Macedo, I. C.; Medeiros, L. F.; Oliveira, C.; Oliveira, C. M.; Rozisky, J. R.; Scarabelot, V. L.; Souza, A.; Silva, F. R.; Santos, V. S.; Cioato, S. G.; Torres, I. L. S.] Hosp Clin Porto Alegre, Anim Experimentat Unit, BR-90035003 Porto Alegre, RS, Brazil.
   [Macedo, I. C.; Medeiros, L. F.; Oliveira, C.; Oliveira, C. M.; Rozisky, J. R.; Scarabelot, V. L.; Souza, A.; Silva, F. R.; Santos, V. S.; Cioato, S. G.; Torres, I. L. S.] Hosp Clin Porto Alegre, Grad Res Grp, BR-90035003 Porto Alegre, RS, Brazil.
   [Caumo, W.] Univ Fed Rio Grande do Sul, Grad Program Med Sci, BR-90035003 Porto Alegre, RS, Brazil.
C3 Universidade Federal do Rio Grande do Sul; Universidade Federal do Rio
   Grande do Sul; Hospital de Clinicas de Porto Alegre; Hospital de
   Clinicas de Porto Alegre; Universidade Federal do Rio Grande do Sul
RP Torres, ILS (corresponding author), Univ Fed Rio Grande do Sul, Inst Ciencias Basicas Saude, Dept Farmacol, Pain Pharmacol Lab, Rua Sarmento Leite 500-202, BR-90050170 Porto Alegre, RS, Brazil.
EM iracitorres@gmail.com
RI Rozisky, Joanna/F-6584-2015; oliveira, cecilia/KIC-3812-2024; caumo,
   wolnei/Q-8728-2016; IC, Macedo/B-3151-2015; Souza, Andressa/Q-2446-2016;
   Oliveira, Cleverson/HPE-1938-2023; Torres, Iraci LS/G-6693-2012;
   Fernandes Medeiros, Liciane/A-3626-2014
OI Souza, Andressa/0000-0002-6608-4695; Macedo, Isabel
   Cristina/0000-0001-6215-1371; Oliveira, Cleverson/0000-0003-0861-6136;
   Torres, Iraci LS/0000-0002-3081-115X; Fernandes Medeiros,
   Liciane/0000-0002-6842-7241; Caumo, Wolnei/0000-0002-5083-4658; Giotti
   Cioato, Stefania/0000-0002-1854-0713
FU National Council for Scientific and Technological Development, CNPq;
   Committee for the Improvement of Higher Education Personnel, CAPES;
   Graduate Research Group of Hospital de Clinicas de Porto Alegre, GPPG
   [09231]; PIBIC HCPA/CNPq
FX This study was supported by the following Brazilian funding agencies:
   the National Council for Scientific and Technological Development, CNPq
   (I.L.S. Torres); the Committee for the Improvement of Higher Education
   Personnel, CAPES (I.C. de Macedo; J.R. Rozisky; and L.F. Medeiros); the
   Graduate Research Group of Hospital de Clinicas de Porto Alegre, GPPG
   (I.L.S. Torres, Grant 09231); and PIBIC HCPA/CNPq (F.R. Silva).
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NR 113
TC 59
Z9 63
U1 0
U2 16
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0196-9781
EI 1873-5169
J9 PEPTIDES
JI Peptides
PD NOV
PY 2012
VL 38
IS 1
BP 189
EP 196
DI 10.1016/j.peptides.2012.08.007
PG 8
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism;
   Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism;
   Pharmacology & Pharmacy
GA 073WL
UT WOS:000313773700025
PM 22940203
OA hybrid
DA 2025-06-11
ER

PT J
AU Faienza, MF
   Cognetti, E
   Farella, I
   Antonioli, A
   Tini, S
   Antoniotti, V
   Prodam, F
AF Faienza, Maria Felicia
   Cognetti, Eleonora
   Farella, Ilaria
   Antonioli, Alessandro
   Tini, Sabrina
   Antoniotti, Valentina
   Prodam, Flavia
TI Dietary fructose: from uric acid to a metabolic switch in pediatric
   metabolic dysfunction-associated steatotic liver disease
SO CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
LA English
DT Review; Early Access
DE Metabolic syndrome; fructose; MASLD; pediatric; uric acid
ID NONALCOHOLIC FATTY LIVER; SUGAR-SWEETENED BEVERAGES; DE-NOVO
   LIPOGENESIS; HEART-FAILURE; PHYSICAL-ACTIVITY; OXIDATIVE STRESS;
   CHILDREN; CONSUMPTION; RISK; INSULIN
AB Fructose consumption in pediatric subjects is rising, as the prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction-associated steatohepatitis (MASH). Despite increasing evidence supporting the detrimental effects of fructose in the development of Metabolic Syndrome (MetS) and its related comorbidities, the association between fructose intake and liver disease remains unclear, mainly in youths. The current narrative review aims to illustrate the correlation between fructose metabolism and liver functions besides its impact on obesity and MASLD in pediatrics. Fructose metabolism is involved in the liver through the classical lipogenic pathway via de novo lipogenesis (DNL) or in the alternative pathway via uric acid accumulation. Hyperuricemia is one of the main features of MALSD patients, underlining how uric acid is growing interest as a new marker of disease. Observational and interventional studies conducted in children and adolescents, who consumed large amounts of fructose and glucose in their diet, were included. Most of these studies emphasized the association between high fructose intake and weight gain, dyslipidemia, insulin resistance, and MASLD/MASH, even in normal-weight children. Conversely, reducing fructose intake ameliorates liver fat accumulation, lipid profile, and weight. In conclusion, fructose seems a potent inducer of both insulin resistance and hepatic fat accumulation.
C1 [Faienza, Maria Felicia; Cognetti, Eleonora] Univ Bari Aldo Moro, Dept Precis & Regenerat Med & Ionian Area, Pediat Unit, Bari, Italy.
   [Farella, Ilaria] Univ Bari Aldo Moro, Dept Precis & Regenerat Med & Ionian Area, Clin Med A Murri, Bari, Italy.
   [Antonioli, Alessandro; Tini, Sabrina; Antoniotti, Valentina; Prodam, Flavia] Univ Piemonte Orientale, Dept Hlth Sci, Novara, Italy.
   [Prodam, Flavia] Univ Piemonte Orientale, Dept Translat Med, Unit Endocrinol, Novara, Italy.
C3 Universita degli Studi di Bari Aldo Moro; Universita degli Studi di Bari
   Aldo Moro; University of Eastern Piedmont Amedeo Avogadro; University of
   Eastern Piedmont Amedeo Avogadro
RP Prodam, F (corresponding author), Univ Piemonte Orientale, Dept Hlth Sci, Novara, Italy.; Prodam, F (corresponding author), Univ Piemonte Orientale, Dept Translat Med, Unit Endocrinol, Novara, Italy.
EM flavia.prodam@med.uniupo.it
RI Faienza, Maria/K-6779-2016; Prodam, Flavia/B-8844-2013
OI Tini, Sabrina/0009-0004-6593-0054; Prodam, Flavia/0000-0001-9660-5335
FU Ministry of Education, Universities, and Research: Grant PRIN (SIDERALE
   project) [2020NCKXBR_004]; Cariplo Foundation [2021-4652]
FX This research was partially supported by: Ministry of Education,
   Universities, and Research: Grant PRIN (SIDERALE project;
   2020NCKXBR_004); and Cariplo Foundation (prot. 2021-4652).
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NR 94
TC 4
Z9 4
U1 2
U2 5
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1040-8398
EI 1549-7852
J9 CRIT REV FOOD SCI
JI Crit. Rev. Food Sci. Nutr.
PD 2024 AUG 13
PY 2024
DI 10.1080/10408398.2024.2392150
EA AUG 2024
PG 16
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA D1N2R
UT WOS:001293917200001
PM 39157959
OA hybrid
DA 2025-06-11
ER

PT J
AU Nishitsuji, K
   Watanabe, S
   Xiao, JZ
   Nagatomo, R
   Ogawa, H
   Tsunematsu, T
   Umemoto, H
   Morimoto, Y
   Akatsu, H
   Inoue, K
   Tsuneyama, K
AF Nishitsuji, Kazuchika
   Watanabe, Syunsuke
   Xiao, Jinzhong
   Nagatomo, Ryosuke
   Ogawa, Hirohisa
   Tsunematsu, Takaaki
   Umemoto, Hitomi
   Morimoto, Yuki
   Akatsu, Hiroyasu
   Inoue, Koichi
   Tsuneyama, Koichi
TI Effect of coffee or coffee components on gut microbiome and short-chain
   fatty acids in a mouse model of metabolic syndrome
SO SCIENTIFIC REPORTS
LA English
DT Article
ID OBESE-DIABETIC MOUSE; NONALCOHOLIC STEATOHEPATITIS; LIVER-DISEASE;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; CHLOROGENIC ACID; DIETARY FIBER;
   INFLAMMATION; DEGRADATION; ARTICLE
AB We previously showed that male Tsumura Suzuki obese diabetes (TSOD) mice, a spontaneous mouse model of metabolic syndrome, manifested gut dysbiosis and subsequent disruption of the type and quantity of plasma short-chain fatty acids (SCFAs), and daily coffee intake prevented nonalcoholic steatohepatitis in this mouse model. Here, we present a preliminary study on whether coffee and its major components, caffeine and chlorogenic acid, would affect the gut dysbiosis and the disrupted plasma SCFA profile of TSOD mice, which could lead to improvement in the liver pathology of these mice. Three mice per group were used. Daily intake of coffee or its components for 16 wk prevented liver lobular inflammation without improving obesity in TSOD mice. Coffee and its components did not repair the altered levels of Gram-positive and Gram-negative bacteria and an increased abundance of Firmicutes in TSOD mice but rather caused additional changes in bacteria in six genera. However, caffeine and chlorogenic acid partially improved the disrupted plasma SCFA profile in TSOD mice, although coffee had no effects. Whether these alterations in the gut microbiome and the plasma SCFA profile might affect the liver pathology of TSOD mice may deserve further investigation.
C1 [Nishitsuji, Kazuchika; Watanabe, Syunsuke; Ogawa, Hirohisa; Tsunematsu, Takaaki; Morimoto, Yuki; Tsuneyama, Koichi] Tokushima Univ, Grad Sch Biomed Sci, Dept Pathol & Lab Med, 3-18-15 Kuramoto Cho, Tokushima 7708503, Japan.
   [Nishitsuji, Kazuchika] Wakayama Med Univ, Dept Biochem, 811-1 Kimiidera, Wakayama 6418509, Japan.
   [Xiao, Jinzhong] Morinaga Milk Ind Co Ltd, Next Generat Sci Inst, 5-1-83 Higashihara, Zama, Kanagawa 2528583, Japan.
   [Nagatomo, Ryosuke; Inoue, Koichi] Ritsumeikan Univ, Coll Pharmaceut Sci, Lab Clin & Analyt Chem, 1-1-1 Nojihigashi, Kusatsu, Shiga 5258577, Japan.
   [Umemoto, Hitomi] Tokushima Univ, Educ Support Room Anat, 3-18-15 Kuramoto Cho, Tokushima 7708503, Japan.
   [Akatsu, Hiroyasu] Nagoya City Univ, Grad Sch Med Sci, Dept Med Aging Pl & Community Based Med Educ, Mizuho Ku, 1 Kawasumi,Mizuho Cho, Nagoya, Aichi 4678601, Japan.
C3 Tokushima University; Wakayama Medical University; Morinaga Milk
   Industry Company, Ltd; Ritsumeikan University; Tokushima University;
   Nagoya City University
RP Tsuneyama, K (corresponding author), Tokushima Univ, Grad Sch Biomed Sci, Dept Pathol & Lab Med, 3-18-15 Kuramoto Cho, Tokushima 7708503, Japan.
EM tsuneyama.koichi@tokushima-u.ac.jp
RI Xiao, Jinzhong/HIR-9791-2022
OI Tsuneyama, Koichi/0000-0002-0670-9868; Tsunematsu,
   Takaaki/0000-0003-1043-2790
FU JSPS KAKENHI from the Japan Society for the Promotion of Science
   [24390181, 25340121, 15K15098]; All Japan Coffee Association;
   Grants-in-Aid for Scientific Research [24390181, 15K15098] Funding
   Source: KAKEN
FX The authors thank the Support Center for Advanced Medical Sciences,
   Institute of Biomedical Sciences, Tokushima University Graduate School.
   This work was supported by JSPS KAKENHI Grant-in-Aid for Scientific
   Research (B) Number 24390181, (C) Number 25340121, Grant-in-Aid for
   Challenging Exploratory Research Number 15K15098 to K.T. from the Japan
   Society for the Promotion of Science, and a research grant of 2012 and
   2015 from the All Japan Coffee Association to K.T.
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NR 59
TC 59
Z9 62
U1 2
U2 29
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD NOV 1
PY 2018
VL 8
AR 16173
DI 10.1038/s41598-018-34571-9
PG 10
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA GY9GX
UT WOS:000448950500025
PM 30385796
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Zhang, YL
   Chen, SM
   Yuan, M
   Xu, Y
   Xu, HX
AF Zhang, Yingling
   Chen, Simin
   Yuan, Man
   Xu, Yu
   Xu, Hongxi
TI Gout and Diet: A Comprehensive Review of Mechanisms and Management
SO NUTRIENTS
LA English
DT Review
DE gout; uric acid; purine; systemic pathways; nutritional factors; dietary
   intervention
ID SERUM URIC-ACID; HIGH-FAT DIET; INSULIN-RESISTANCE; ASCORBIC-ACID;
   RISK-FACTORS; ASYMPTOMATIC HYPERURICEMIA; NLRP3 INFLAMMASOME; METABOLIC
   SYNDROME; OXIDATIVE STRESS; PROTEIN-INTAKE
AB Gout is well known as an inflammatory rheumatic disease presenting with arthritis and abnormal metabolism of uric acid. The recognition of diet-induced systemic metabolic pathways have provided new mechanistic insights and potential interventions on gout progression. However, the dietary recommendations for gouty patients generally focus on food categories, with few simultaneous considerations of nutritional factors and systemic metabolism. It is worthwhile to comprehensively review the mechanistic findings and potential interventions of diet-related nutrients against the development of gout, including purine metabolism, urate deposition, and gouty inflammation. Although piecemeal modifications of various nutrients often provide incomplete dietary recommendations, understanding the role of nutritional factors in gouty development can help patients choose their healthy diet based on personal preference and disease course. The combination of dietary management and medication may potentially achieve enhanced treatment effects, especially for severe patients. Therefore, the role of dietary and nutritional factors in the development of gout is systematically reviewed to propose dietary modification strategies for gout management by: (1) reducing nutritional risk factors against metabolic syndrome; (2) supplementing with beneficial nutrients to affect uric acid metabolism and gouty inflammation; and (3) considering nutritional modification combined with medication supplementation to decrease the frequency of gout flares.
C1 [Zhang, Yingling; Chen, Simin; Yuan, Man; Xu, Yu] Shanghai Univ Tradit Chinese Med, Sch Pharm, Shanghai 201203, Peoples R China.
   [Zhang, Yingling; Chen, Simin; Yuan, Man; Xu, Yu; Xu, Hongxi] Shanghai Coll TCM New Drug Discovery, Engn Res Ctr, Shanghai 201203, Peoples R China.
   [Xu, Hongxi] Shanghai Univ Tradit Chinese Med, Shuguang Hosp, Shanghai 201203, Peoples R China.
C3 Shanghai University of Traditional Chinese Medicine; Shanghai University
   of Traditional Chinese Medicine
RP Xu, Y (corresponding author), Shanghai Univ Tradit Chinese Med, Sch Pharm, Shanghai 201203, Peoples R China.; Xu, Y; Xu, HX (corresponding author), Shanghai Coll TCM New Drug Discovery, Engn Res Ctr, Shanghai 201203, Peoples R China.; Xu, HX (corresponding author), Shanghai Univ Tradit Chinese Med, Shuguang Hosp, Shanghai 201203, Peoples R China.
EM xyzjh2021@shutcm.edu.cn; hxxu@shutcm.edu.cn
RI Chen, Simin/AAH-5818-2019; Xu, Hongxi/AAC-2799-2020; yuan,
   man/KBC-5902-2024
FU Key-Area Research and Development Program of Guangdong Province
   [2020B1111110003]
FX This research was funded by the Key-Area Research and Development
   Program of Guangdong Province (2020B1111110003).
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NR 131
TC 56
Z9 61
U1 13
U2 56
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD SEP
PY 2022
VL 14
IS 17
AR 3525
DI 10.3390/nu14173525
PG 22
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 4K2XL
UT WOS:000851819300001
PM 36079783
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Claro-Cala, CM
   Jiménez-Altayó, F
   Zagmutt, S
   Rodriguez-Rodriguez, R
AF Claro-Cala, Carmen M.
   Jimenez-Altayo, Francesc
   Zagmutt, Sebastian
   Rodriguez-Rodriguez, Rosalia
TI Molecular Mechanisms Underlying the Effects of Olive Oil Triterpenic
   Acids in Obesity and Related Diseases
SO NUTRIENTS
LA English
DT Review
DE triterpenes; olive oil; obesity; insulin resistance; adiposity; vascular
   diseases; oleanolic acid
ID NITRIC-OXIDE SYNTHASE; OLEANOLIC ACID; URSOLIC ACID; ENDOTHELIAL
   FUNCTION; INSULIN-RESISTANCE; 3T3-L1 ADIPOCYTES; OXIDATIVE STRESS;
   MASLINIC ACID; HIGH-FAT; ANTIOXIDANT
AB Dietary components exert protective effects against obesity and related metabolic and cardiovascular disturbances by interfering with the molecular pathways leading to these pathologies. Dietary biomolecules are currently promising strategies to help in the management of obesity and metabolic syndrome, which are still unmet medical issues. Olive oil, a key component of the Mediterranean diet, provides an exceptional lipid matrix highly rich in bioactive molecules. Among them, the pentacyclic triterpenic acids (i.e., oleanolic acid) have gained clinical relevance in the last decade due to their wide range of biological actions, particularly in terms of vascular function, obesity and insulin resistance. Considering the promising effects of these triterpenic compounds as nutraceuticals and components of functional foods against obesity and associated complications, the aim of our review is to decipher and discuss the main molecular mechanisms underlying these effects driven by olive oil triterpenes, in particular by oleanolic acid. Special attention is paid to their signaling and targets related to glucose and insulin homeostasis, lipid metabolism, adiposity and cardiovascular dysfunction in obesity. Our study is aimed at providing a better understanding of the impact of dietary components of olive oil in the long-term management of obesity and metabolic syndrome in humans.
C1 [Claro-Cala, Carmen M.] Univ Seville, Dept Pharmacol, Pediat Radiol, Fac Med, Seville 41009, Spain.
   [Jimenez-Altayo, Francesc] Univ Autonoma Barcelona, Inst Neurociencies, Fac Med, Dept Farmacol, Bellaterra 08193, Spain.
   [Zagmutt, Sebastian; Rodriguez-Rodriguez, Rosalia] Univ Int Catalunya, Dept Basic Sci, Fac Med & Hlth Sci, Sant Cugat Del Valles 08195, Spain.
C3 University of Sevilla; Autonomous University of Barcelona; Universitat
   Internacional de Catalunya (UIC)
RP Rodriguez-Rodriguez, R (corresponding author), Univ Int Catalunya, Dept Basic Sci, Fac Med & Hlth Sci, Sant Cugat Del Valles 08195, Spain.
EM cmclaro@us.es; francesc.jimenez@uab.cat; szagmutt@uic.es;
   rrodriguez@uic.es
RI Claro-Cala, Carmen-Maria/F-7886-2016; Jimenez Altayo,
   Francesc/F-1245-2011; Zagmutt, Sebastian/J-7144-2017
OI Claro-Cala, Carmen-Maria/0000-0001-9943-405X; Jimenez Altayo,
   Francesc/0000-0002-9034-2041; Zagmutt, Sebastian/0000-0001-6050-4452
FU Spanish Ministerio de Ciencia e Innovacion; AEI (Agencia Estatal de
   Investigacion); FEDER (Fondo Europeo de Desarrollo Regional)
   [PID2020114953RB-C22, PID2020-113634RB-C22]; MCIN/AEI
   [CI2018-092997/AEI]
FX The author's work is supported by the Spanish Ministerio de Ciencia e
   Innovacion, AEI (Agencia Estatal de Investigacion), FEDER (Fondo Europeo
   de Desarrollo Regional) (Grants PID2020114953RB-C22 to R.R.-R.,
   PID2020-113634RB-C22 to F.J.-A., by MCIN/AEI/10.13039/501100011033, and
   PCI2018-092997/AEI to R.R.-R.).
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NR 84
TC 19
Z9 19
U1 1
U2 18
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD APR
PY 2022
VL 14
IS 8
AR 1606
DI 10.3390/nu14081606
PG 17
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 0T5MP
UT WOS:000787012800001
PM 35458168
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Chin, KY
   Ima-Nirwana, S
AF Chin, Kok-Yong
   Ima-Nirwana, Soelaiman
TI The Role of Tocotrienol in Preventing Male Osteoporosis-A Review of
   Current Evidence
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE antioxidant; inflammation; men; mevalonate; osteopenia; skeleton;
   tocochromanol; vitamin E
ID BONE-MINERAL DENSITY; NF-KAPPA-B; BIXA-ORELLANA ANNATTO; HMG-COA
   REDUCTASE; OXIDATIVE STRESS; VITAMIN-E; GAMMA-TOCOTRIENOL;
   DELTA-TOCOTRIENOL; MALE RATS; METABOLIC SYNDROME
AB Male osteoporosis is a significant but undetermined healthcare problem. Men suffer from a higher mortality rate post-fracture than women and they are marginalized in osteoporosis treatment. The current prophylactic agents for osteoporosis are limited. Functional food components such as tocotrienol may be an alternative option for osteoporosis prevention in men. This paper aims to review the current evidence regarding the skeletal effects of tocotrienol in animal models of male osteoporosis and its potential antiosteoporotic mechanism. The efficacy of tocotrienol of various sources (single isoform, palm and annatto vitamin E mixture) had been tested in animal models of bone loss induced by testosterone deficiency (orchidectomy and buserelin), metabolic syndrome, nicotine, alcoholism, and glucocorticoid. The treated animals showed improvements ranging from bone microstructural indices, histomorphometric indices, calcium content, and mechanical strength. The bone-sparing effects of tocotrienol may be exerted through its antioxidant, anti-inflammatory, and mevalonate-suppressive pathways. However, information pertaining to its mechanism of actions is superficial and warrants further studies. As a conclusion, tocotrienol could serve as a functional food component to prevent male osteoporosis, but its application requires validation from a clinical trial in men.
C1 [Chin, Kok-Yong; Ima-Nirwana, Soelaiman] Univ Kebangsaan Malaysia, Dept Pharmacol, Fac Med, Jalan Yaacob Latif, Bandar Tun Razak 56000, Cheras, Malaysia.
C3 Universiti Kebangsaan Malaysia
RP Chin, KY (corresponding author), Univ Kebangsaan Malaysia, Dept Pharmacol, Fac Med, Jalan Yaacob Latif, Bandar Tun Razak 56000, Cheras, Malaysia.
EM chinkokyong@ppukm.ukm.edu.my; imasoel@ppukm.ukm.edu.my
RI Chin, Kok-Yong/B-6309-2015
OI Chin, Kok-Yong/0000-0001-6628-1552
FU Ministry of Education, Malaysia [FRGS/1/2018/SKK10/UKM/03/1]; Universiti
   Kebangsaan Malaysia [GUP-2017-060]
FX The authors are funded by Ministry of Education, Malaysia through grant
   FRGS/1/2018/SKK10/UKM/03/1 and Universiti Kebangsaan Malaysia through
   grant GUP-2017-060.
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NR 164
TC 24
Z9 25
U1 2
U2 5
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD MAR 18
PY 2019
VL 20
IS 6
AR 1355
DI 10.3390/ijms20061355
PG 20
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA HT1KN
UT WOS:000464322800008
PM 30889819
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Tan, CK
   Zhuang, Y
   Wahli, W
AF Tan, Chek Kun
   Zhuang, Yan
   Wahli, Walter
TI Synthetic and natural Peroxisome Proliferator-Activated Receptor (PPAR)
   agonists as candidates for the therapy of the metabolic syndrome
SO EXPERT OPINION ON THERAPEUTIC TARGETS
LA English
DT Review
DE Agonists; insulin resistance; lipid metabolism; metabolic syndrome;
   PPARs; type 2 diabetes; phytochemicals
ID ENDOPLASMIC-RETICULUM STRESS; ALPHA/GAMMA DUAL AGONIST; DIET-INDUCED
   OBESITY; INSULIN-RESISTANCE; NUCLEAR RECEPTORS; LIPID-METABOLISM;
   GAMMA-AGONIST; SKELETAL-MUSCLE; ADIPOSE-TISSUE; RETINOIC ACID
AB Introduction: Peroxisome proliferator-activated receptors (PPARs) are the molecular targets of hypolipidemic and insulin-sensitizing drugs and implicated in a multitude of processes that fine-tune the functions of all organs in vertebrates. As transcription factors they sense endogenous and exogenous lipid signaling molecules and convert these signals into intricate gene responses that impact health and disease. The PPARs act as modulators of cellular, organ, and systemic processes, such as lipid and carbohydrate metabolism, making them valuable for understanding body homeostasis influenced by nutrition and exercise.Areas covered: This review concentrates on synthetic and natural PPAR ligands and how they have helped reveal many aspects of the transcriptional control of complex processes important in health.Expert opinion: The three PPARs have complementary roles in the fine-tuning of most fundamental body functions, especially energy metabolism. Understanding their inter-relatedness using ligands that simultaneously modulate the activity of more than one of these receptors is a major goal. This approach may provide essential knowledge for the development of dual or pan-PPAR agonists or antagonists as potential new health-promoting agents and for nutritional approaches to prevent metabolic diseases.
C1 [Tan, Chek Kun; Zhuang, Yan; Wahli, Walter] Nanyang Technol Univ, Lee Kong Chian Sch Med, 20 Coll Rd, Singapore 169856, Singapore.
   [Wahli, Walter] Univ Lausanne, Ctr Integrat Genom, Lausanne, Switzerland.
C3 Nanyang Technological University; University of Lausanne
RP Wahli, W (corresponding author), Nanyang Technol Univ, Lee Kong Chian Sch Med, 20 Coll Rd, Singapore 169856, Singapore.
EM walter.wahli@ntu.edu.sg
RI Wahli, Walter/I-3194-2019
FU Lee Kong Chian School of Medicine, Nanyang Technological University
   (Start-Up Grant); Ministry of Education, Singapore [2015-T1-001-034]
FX This paper was funded by Lee Kong Chian School of Medicine, Nanyang
   Technological University (Start-Up Grant) and the Ministry of Education,
   Singapore [2015-T1-001-034].
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NR 118
TC 57
Z9 62
U1 1
U2 31
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1472-8222
EI 1744-7631
J9 EXPERT OPIN THER TAR
JI Expert Opin. Ther. Targets
PD MAR
PY 2017
VL 21
IS 3
BP 333
EP 348
DI 10.1080/14728222.2017.1280467
PG 16
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA EM3FZ
UT WOS:000395201200010
PM 28092722
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Sirover, MA
AF Sirover, MA
TI New nuclear functions of the glycolytic protein,
   glyceraldehyde-3-phosphate dehydrogenase, in mammalian cells
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Article
DE glyceraldehyde-3-phosphate dehydrogenase; GAPDH; transcriptional
   regulation; membrane fusion; cancer chemotherapy; telomere structure;
   metabolic syndrome; post-translational modification
ID INHIBITION; EXPRESSION; IDENTIFICATION; COMPLEX; GAPDH; PHOSPHORYLATION;
   TRANSLOCATION; ACTIVATION; APOPTOSIS; PROMOTER
AB Recent studies establish that the glycolytic protein, glyceraldehyde-3-phosphate dehydrogenase (GAPDH), is not simply a classical metabolic protein involved in energy production. Instead, it is a multifunctional protein with defined functions in numerous subcellular processes. New investigations establish a primary role for GAPDH in a variety of critical nuclear pathways apart from its already recognized role in apoptosis. These new roles include its requirement for transcriptional control of histone gene expression, its essential function in nuclear membrane fusion, its necessity for the recognition of fraudulently incorporated nucleotides in DNA, and its mandatory participation in the maintenance of telomere structure. Each of these new functions requires GAPDH association into a series of multienzyme complexes. Although other proteins in those complexes are variable, GAPDH remains the single constant protein in each structure. To undertake these new functions, GAPDH is recruited to the nucleus in S phase or its intracellular distribution is regulated as a function of drug exposure. Other investigations relate a substantial role for nuclear GAPDH in hyperglycemic stress and the development of metabolic syndrome. Considerations Of future directions as well as the role of 6 GAPDH post-translational modification as a basis for its multifunctional activities is suggested. (c) 2005 Wiley-Liss, Inc.
C1 Temple Univ, Sch Med, Dept Pharmacol, Philadelphia, PA 19140 USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE); Temple
   University
RP Temple Univ, Sch Med, Dept Pharmacol, 3420 N Broad St, Philadelphia, PA 19140 USA.
EM msirover@temple.edu
FU NIA NIH HHS [AG14566] Funding Source: Medline
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NR 57
TC 262
Z9 312
U1 0
U2 13
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0730-2312
EI 1097-4644
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PD MAY 1
PY 2005
VL 95
IS 1
BP 45
EP 52
DI 10.1002/jcb.20399
PG 8
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA 921DI
UT WOS:000228744000005
PM 15770658
DA 2025-06-11
ER

PT J
AU Mustafa, ZA
   Ali, RH
   Ali, DR
   Abdulkarimi, R
   Abdulkareem, NK
   Akbari, A
AF Ahmed Mustafa, Zana
   Hamed Ali, Rojgar
   Rostum Ali, Dler
   Abdulkarimi, Rahim
   Abdulkareem, Nashwan K.
   Akbari, Abolfazl
TI The combination of ginger powder and zinc supplement improves the
   fructose-induced metabolic syndrome in rats by modulating the hepatic
   expression of NF-κB, mTORC1, PPAR-α SREBP-1c, and Nrf2
SO JOURNAL OF FOOD BIOCHEMISTRY
LA English
DT Article
DE autophagy; ginger; inflammation; metabolic syndrome; oxidative stress;
   zinc
ID ZINGIBER-OFFICINALE-ROSCOE; HIGH-FAT DIET; INSULIN-RESISTANCE; OXIDATIVE
   STRESS; FOOD-INTAKE; ACTIVATION; AUTOPHAGY; RECEPTOR; INFLAMMATION;
   EXTRACT
AB Although studies have shown that ginger, as an herbal remedy and zinc are able to improve inflammation, oxidative stress, autophagy, and metabolism of lipid and glucose, their molecular mechanisms are unknown. Therefore, this study was aimed to examine the therapeutic effects of ginger with zinc supplement for eight weeks on fructose-induced metabolic syndrome (MS). Ninety-six adult male Sprague Dawley rats (220 g +/- 20) were randomly assigned to twelve controlled and treated groups. After the last treatment session, the level of lipid profiles, glucose, insulin, and leptin as metabolic factors and liver enzymes as biomarkers to evaluate liver function in serum were measured. The level of antioxidant enzymes and lipid peroxidation to evaluate the oxidative status and the TNF-alpha level as a biomarker to assess the state of inflammation in liver were also measured. The level of zinc along with the expression of NF-kappa B, mTORC1, PPAR-alpha, SREBP-1c, and Nrf2 in liver was also evaluated. The level of metabolic factors and liver enzymes in serum along with lipid peroxidation and TNF-alpha in liver increased; zinc and antioxidant enzymes levels decreased in rats with MS compared to control rats (p < .05). The hepatic expression of SREBP-1c, NF-kappa B and mTORC1 were upregulated and the expression of PPAR-alpha and Nrf2 were downregulated in rats with MS compared to control rats (p < .05). Treatment with different doses of ginger, zinc, and the combination of them could improve metabolic, inflammatory oxidative stress factors, and expression of the above genes in rats with MS compared to the MS group (p < .05). It can be concluded that ginger, zinc, and the combination of them could improve oxidative damage, inflammation, and autophagy induced by fructose and could adjust the glucose and lipid metabolism and the homeostasis of zinc in rats with MS.
   Practical applications Due to the increasing prevalence of metabolic diseases, the use of plant compounds such as ginger has attracted widespread attention. Ginger as an herbal remedy with predominant pharmacological properties due to its availability, cheapness, and lack of side effects is also very popular for the treatment of metabolic disorders in folk medicine. Moreover, enhancing its medicinal properties with supplements such as zinc can be widely welcomed. This study was actually performed with the aim of investigating the effects of ginger + zinc supplement on MS. The results showed that the ginger + zinc supplement could improve oxidative damage, inflammation, and autophagy caused by fructose and adjust the glucose and lipid metabolism and the homeostasis of zinc in rats with MS. The results of this study support the hypothesis that ginger can be used as a very suitable option for the production of medicinal supplements to maintain human health.
C1 [Ahmed Mustafa, Zana] Erbil Polytech Univ, Med Tech Inst, Dept Pharm, Erbil, Iraq.
   [Hamed Ali, Rojgar] Hawler Med Univ, Dept Pharmacol & Toxicol, Coll Pharm, Erbil, Iraq.
   [Rostum Ali, Dler] Hawler Med Univ, Basic Sci Dept, Coll Med, Erbil, Iraq.
   [Abdulkarimi, Rahim] Dept Environm, Boukan, Iran.
   [Abdulkarimi, Rahim] Univ Zanjan, Dept Anim Sci, Fac Agr, Zanjan, Iran.
   [Abdulkareem, Nashwan K.] Hawler Med Univ, Dept Basic Sci, Coll Med, Biophys Unit, Erbil, Iraq.
   [Akbari, Abolfazl] Shiraz Univ, Sch Vet Med, Dept Physiol, Shiraz, Iran.
C3 Erbil Polytechnic University; Hawler Medical University; Hawler Medical
   University; University Zanjan; Hawler Medical University; Shiraz
   University
RP Akbari, A (corresponding author), Shiraz Univ, Sch Vet Med, Dept Physiol, Shiraz, Iran.
EM Akbariabolfazl@gmail.com
RI Akbari, Abolfazl/R-9118-2017
OI Ahmed, Zana/0000-0001-7111-250X; Akbari, Abolfazl/0000-0002-1577-4346
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NR 74
TC 17
Z9 18
U1 0
U2 11
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0145-8884
EI 1745-4514
J9 J FOOD BIOCHEM
JI J. Food Biochem.
PD JAN
PY 2021
VL 45
IS 1
AR e13546
DI 10.1111/jfbc.13546
EA NOV 2020
PG 16
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA PV2NW
UT WOS:000584266900001
PM 33145794
OA gold
DA 2025-06-11
ER

PT J
AU Li, JJ
   Wang, Y
   Nie, SP
   Li, Q
   Li, YS
   Huang, Y
   Hui, RT
AF Li, Jian-Jun
   Wang, Ying
   Nie, Shao-Ping
   Li, Qian
   Li, Yi-Shi
   Huang, Yuan
   Hui, Ru-Tai
TI Xuezhikang, an extract of cholestin, decreases plasma inflammatory
   markers and endothelin-1, improve exercise-induced ischemia and
   subjective feelings in patients with cardiac syndrome X
SO INTERNATIONAL JOURNAL OF CARDIOLOGY
LA English
DT Article
DE Xuezhikang; lipid profile; C-reactive protein; interleukin-6;
   endothelin-1; exercise test; cardiac syndrome X
ID C-REACTIVE PROTEIN; LIPID PROFILE
AB Previous studies have demonstrated that Xuezhikang, an extract of cholestin, available from Chinese red yeast rice, could effectively modify lipid profile. The present study was undertaken to investigate whether Xuezhikang could modify endothelin- 1 ( ET- 1), interleukin- 6 ( IL- 6), high- sensitivity C- reactive protein ( CRP) and exercise- induced ischemia in patients with cardiac syndrome X ( CSX). Thirty- six patients with CSX were randomly assigned to 1200 mg/ d of Xuezhikang or placebo group ( n= 18 respectively). Blood samples were drawn at day 0 and day 90 for measuring above parameters. The treadmill exercise tests and subjective feelings were also assessed at day 0 and day 90. The data showed that Xuezhikang therapy resulted in significant reductions in total cholesterol ( TC, 19%), low- density lipoprotein cholesterol ( LDL- C) ( 26%), and triglycerides ( TG) compared with baseline ( 16%, p<0.01 respectively). The data also showed that Xuezhikang led significantly to reductions in median and log- CRP levels ( 38% and 44%, p<0.01 respectively), IL- 6 ( 20%, p<0.01), and ET- 1 ( 47%, p<0.01) compared with baseline. The exercise duration, and time to 1 mm ST- segment depression was significantly prolonged after Xuezhikang therapy ( 9% and 6%, p<0.05 respectively) accompanied by improvement of subjective feelings. Data suggested that the benefit of Xuezhikang resulted in significant modification vascular function by reduction of ET- 1, inflammatory markers and LDL cholesterol, which may be clinically important for patients with CSX. (C) 2006 Elsevier Ireland Ltd. All rights reserved.
C1 Chinese Acad Med Sci, Fu Wai Hosp, Peking Union Med Coll, Dept Cardiol, Beijing 100037, Peoples R China.
   Zhengzhou Univ, Sch Med, Affiliated Hosp 1, Dept Geriatr, Zhengzhou 450000, Peoples R China.
   Capital Univ Med Sci, Beijing Anzhen Hosp, Dept Cardiol, Beijing 100029, Peoples R China.
   Peking Univ, Undergrad Coll Life Sci, Beijing 100023, Peoples R China.
C3 Chinese Academy of Medical Sciences - Peking Union Medical College;
   Peking Union Medical College; Fu Wai Hospital - CAMS; Zhengzhou
   University; Capital Medical University; Peking University
RP Li, JJ (corresponding author), Chinese Acad Med Sci, Fu Wai Hosp, Peking Union Med Coll, Dept Cardiol, Beijing 100037, Peoples R China.
EM lijnjn@yahoo.com.cn
RI Li, Qianxian/HGD-5869-2022
OI Nie, Shao-Ping/0000-0002-2412-4679
CR Li Jian-Jun, 2005, Clinica Chimica Acta, V352, P127
   Li Jian-Jun, 2004, Heart Lung Circ, V13, P173, DOI 10.1016/j.hlc.2004.02.005
   Li JJ, 2006, MED HYPOTHESES, V66, P504, DOI 10.1016/j.mehy.2005.09.028
   Li JJ, 2005, CHINESE MED J-PEKING, V118, P1817
   Li JJ, 2005, CLIN CHIM ACTA, V352, P217, DOI 10.1016/j.cccn.2004.09.026
   Li JJ, 2003, CLIN CARDIOL, V26, P472, DOI 10.1002/clc.4960261008
   Li JJ, 2002, ANGIOLOGY, V53, P409, DOI 10.1177/000331970205300406
   Teragawa H, 2004, HEART, V90, P750, DOI 10.1136/hrt.2003.022269
   Tousoulis D, 2001, CLIN CARDIOL, V24, P301, DOI 10.1002/clc.4960240409
NR 9
TC 23
Z9 26
U1 2
U2 8
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0167-5273
EI 1874-1754
J9 INT J CARDIOL
JI Int. J. Cardiol.
PD OCT
PY 2007
VL 122
IS 1
BP 82
EP 84
DI 10.1016/j.ijcard.2006.11.031
PG 3
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 231XR
UT WOS:000250983000017
PM 17196275
DA 2025-06-11
ER

PT J
AU Farinholt, GN
   Carr, AD
   Chang, EJ
   Ali, MR
AF Farinholt, Gina N.
   Carr, Aaron D.
   Chang, Eun Jin
   Ali, Mohamed R.
TI A call to arms: obese men with more severe comorbid disease and
   underutilization of bariatric operations
SO SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
LA English
DT Article; Proceedings Paper
CT Annual Meeting of the
   Society-of-American-Gastrointestinal-and-Endoscopic-Surgeons (SAGES)
CY APR 17-20, 2013
CL Baltimore, MD
SP Soc Amer Gastrointestinal & Endoscop Surg
DE Male comorbidities; Metabolic syndrome; Bariatric surgery; Diabetes;
   Hypertension; Obesity
ID BODY-MASS INDEX; MORTALITY RISK SCORE; LONG-TERM MORTALITY; GASTRIC
   BYPASS; METABOLIC SYNDROME; SURGERY; OVERWEIGHT; ADULTS; ASSOCIATION;
   PREVALENCE
AB Despite similar rates of obesity among American men and women, population-based studies suggest that bariatric surgery patients are disproportionately female. We sought to assess this observation quantitatively.
   Data were prospectively collected from 1,368 consecutive patients evaluated for bariatric surgery over a 4-year period. The prevalence of diabetes mellitus (DM), hypertension (HTN), dyslipidemia (DYS), obstructive sleep apnea (OSA), gastroesophageal reflux disease, depression, back pain (BKP), and musculoskeletal peripheral disease was assessed. A severity score from 1 to 5 had been assigned to each comorbidity based on the Assessment of Obesity Related Comorbidities Scale (AORC). Metabolic syndrome (MetS) was defined as the concurrent presence of DM, HTN, and DYS.
   The majority of patients were female (n = 1,115, 81.5 %). Male patients were older (44.5 +/- A 9.5 vs. 42.6 +/- A 9.6 years, p = 0.0044) and had higher body mass index (48.7 +/- A 7.8 vs. 46.6 +/- A 7.4 kg/m(2), p < 0.0001). On average, men presented with 4.54 serious comorbidities and 3.7 complicated comorbidities (AORC score a parts per thousand yen3), whereas women presented with 4.15 serious comorbidities and 3.08 complicated comorbidities. More men presented with DM (36.4 vs. 28.9 %, p = 0.0154), HTN (68.8 vs. 55.3 %, p = 0.0001), OSA (71.9 vs. 45.7 %, p < 0.0001), and MetS (20.9 vs. 15.2 %, p = 0.0301). Men also presented with more complicated DM (33.2 vs. 23.9 %, p = 0.0031), DYS (36.8 vs. 23.5 %, p < 0.0001), HTN (58.9 vs. 44.6 %, p < 0.0001), BKP (25.3 vs. 19.3 %, p = 0.0378), OSA (56.9 vs. 30.1 %, p < 0.0001), and MetS (17.8 vs. 10.0 %, p = 0.001).
   Although men typically comprise less than 20 % of bariatric surgery patients, they potentially have more to gain from these operations. Men present later in life, with more advanced obesity, and with more complicated comorbidities. Such findings mandate more research and resources to investigate this barrier to treatment and to provide the morbidly obese male with the surgical care he clearly needs.
C1 [Farinholt, Gina N.; Carr, Aaron D.; Chang, Eun Jin; Ali, Mohamed R.] Univ Calif Davis, Dept Surg, Sacramento, CA 95817 USA.
C3 University of California System; University of California Davis
RP Ali, MR (corresponding author), Univ Calif Davis, Dept Surg, 2221 Stockton Blvd, Sacramento, CA 95817 USA.
EM alimr@ucdavis.edu
RI Ali, Mohamed/ABI-6395-2020
CR Adams TD, 2007, NEW ENGL J MED, V357, P753, DOI 10.1056/NEJMoa066603
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   Sjöström L, 2012, JAMA-J AM MED ASSOC, V307, P56, DOI 10.1001/jama.2011.1914
   Skinner J, 2003, NEW ENGL J MED, V349, P1350, DOI 10.1056/NEJMsa021569
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   Yager SS, 2013, AM J CLIN ONCOL
NR 36
TC 42
Z9 46
U1 0
U2 5
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0930-2794
EI 1432-2218
J9 SURG ENDOSC
JI Surg. Endosc.
PD DEC
PY 2013
VL 27
IS 12
BP 4556
EP 4563
DI 10.1007/s00464-013-3122-1
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA 254DQ
UT WOS:000327144800020
PM 23949482
DA 2025-06-11
ER

PT J
AU Fortuna, RJ
   Holub, A
   Turk, MA
   Meccarello, J
   Davidson, PW
AF Fortuna, Robert J.
   Holub, Ashley
   Turk, Margaret A.
   Meccarello, Jon
   Davidson, Philip W.
TI Health conditions, functional status and health care utilization in
   adults with cerebral palsy
SO FAMILY PRACTICE
LA English
DT Article
DE Access to care; aging; chronic disease; developmental disabilities;
   motor development/cerebral palsy
ID QUALITY-OF-LIFE; YOUNG-ADULTS; DEVELOPMENTAL-DISABILITIES; INTELLECTUAL
   DISABILITIES; CARDIOMETABOLIC RISK; RECENT TRENDS; PREVALENCE; CHILDREN;
   PEOPLE; DEPRESSION
AB Aim. Health conditions in children with cerebral palsy (CP) are well described, yet health is less defined with advancing age. We examined health conditions, functional status and health care utilization in adults with CP across age groups.
   Methods. We collected cross-sectional data on health conditions, functional status and utilization from the medical records of adults with CP across a large university-affiliated primary care network using the Rochester Health Status Survey IV (RHSS-IV), a 58-item validated survey. Data from the National Health and Nutrition Examination Survey and National Health Interview Survey provided prevalence estimates for the general population as comparison.
   Results. Compared to the general population, adults with CP had higher rates of seizure disorder, obesity and asthma across all ages. Adults with CP under 30 years of age had higher rates of hypertension (16.7 versus 5.6%; P = 0.04), urinary incontinence (41.7 versus 10.5%; P < 0.001) and depression (16.7 versus 6.9%; P = 0.07). Conversely, there were lower rates of alcohol misuse, tobacco/nicotine and sexually transmitted illnesses. Independence with all activities of daily living decreased from 37.5% at 18-29 years of age to 22.5% in those 60 and over. Seizure disorders, urinary incontinence and gastroesophageal reflux disease were all independently associated with lower functional status. As expected, health care utilization increased with advancing age.
   Conclusions: Adults with CP should be monitored for conditions occurring at higher prevalence in CP, as well as common conditions occurring with advancing age. Age-related functional decline should be anticipated, especially with coexisting seizure disorders and urinary incontinence.
C1 [Fortuna, Robert J.] Univ Rochester, Dept Internal Med, Rochester, NY USA.
   [Fortuna, Robert J.] Univ Rochester, Dept Pediat, Rochester, NY USA.
   [Holub, Ashley] Univ Rochester, Dept Publ Hlth Sci, Rochester, NY USA.
   [Turk, Margaret A.] State Univ New York Upstate Med Univ, Dept Pediat & Phys Med & Rehabil, Syracuse, NY USA.
   [Meccarello, Jon; Davidson, Philip W.] Univ Rochester, Dept Pediat Neurodev & Behav Pediat, Rochester, NY USA.
C3 University of Rochester; University of Rochester; University of
   Rochester; State University of New York (SUNY) System; State University
   of New York (SUNY) Upstate Medical Center; University of Rochester
RP Fortuna, RJ (corresponding author), Univ Rochester, Sch Med & Dent, Dept Internal Med, Rochester, NY 14627 USA.; Fortuna, RJ (corresponding author), Univ Rochester, Sch Med & Dent, Dept Pediat, Rochester, NY 14642 USA.
EM robert_fortuna@urmc.rochester.edu
RI Holub, Ashley/AAM-6870-2020; Turk, Matthew/GXV-9589-2022
OI Holub, Ashley/0000-0003-0894-9184
FU Rehabilitation Research and Training Center on Aging with Developmental
   Disabilities (RRTCADD), Department of Disability and Human Development
   at the University of Illinois at Chicago; US Department of Education,
   Office of Special Education and Rehabilitative Services, National
   Institute on Disability and Rehabilitation Research [H133B080009]
FX This research was supported in part by a sub-contract to the University
   of Rochester from the Rehabilitation Research and Training Center on
   Aging with Developmental Disabilities (RRTCADD), Department of
   Disability and Human Development at the University of Illinois at
   Chicago. The RRTCADD is funded by Grant # H133B080009 from the US
   Department of Education, Office of Special Education and Rehabilitative
   Services, National Institute on Disability and Rehabilitation Research.
CR Anderson LL, 2013, INTELLECT DEV DISAB, V51, P385, DOI 10.1352/1934-9556-51.5.385
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NR 53
TC 36
Z9 37
U1 0
U2 6
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0263-2136
EI 1460-2229
J9 FAM PRACT
JI Fam. Pr.
PD DEC
PY 2018
VL 35
IS 6
BP 661
EP 670
DI 10.1093/fampra/cmy027
PG 10
WC Primary Health Care; Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA HH9UA
UT WOS:000456084500004
PM 29718268
OA Bronze
DA 2025-06-11
ER

PT J
AU De Lorenzo, A
   Bernardini, S
   Gualtieri, P
   Cabibbo, A
   Perrone, MA
   Giambini, I
   Di Renzo, L
AF De Lorenzo, Antonino
   Bernardini, Sergio
   Gualtieri, Paola
   Cabibbo, Andrea
   Perrone, Marco Alfonso
   Giambini, Ilio
   Di Renzo, Laura
TI Mediterranean meal versus Western meal effects on postprandial ox-LDL,
   oxidative and inflammatory gene expression in healthy subjects: a
   randomized controlled trial for nutrigenomic approach in cardiometabolic
   risk
SO ACTA DIABETOLOGICA
LA English
DT Article
DE Oxidized-LDL; Nutrigenomic; Mediterranean meal; CVD
ID OXIDIZED LDL; DIET; ANTIOXIDANT; MARKERS; STRESS; ATHEROGENESIS;
   MECHANISMS; DISEASE; ADULTS; ACIDS
AB Inflammation and oxidative damage contribute significantly to the development of cardiovascular diseases (CVD). Postprandial oxidative stress and inflammation are characterized by an increased susceptibility of the organism toward oxidative damage after consumption of a meal rich in lipids and/or carbohydrates. Micronutrients modulate immune system and exert a protective action by reducing oxidized low-density lipoprotein (ox-LDL) level. The aim of the present study was to evaluate the postprandial plasma ox-LDL level and the gene expression of 13 genes related to oxidative stress (HOSp) and human inflammasome pathways (HIp), after a tocopherol-enriched Mediterranean meal (TEM), and a Western high-fat meal (HFM). Moreover, Mediterranean Adequacy Index was calculated to define the quality of both meals.
   We set up a randomized and crossover trial in healthy human volunteers. Ox-LDL level was measured by enzyme-linked immunosorbent assay and the gene expression of 13 genes related to HOSp and HIp by qRT-PCR.
   Ox-LDL levels significantly decreased comparing HFM versus TEM (p < 0.05). Percentages of significantly overexpressed genes after each dietary treatment are as follows: (A) baseline versus HFM: 7.69 % HIp and 23.08 % HOSp; (B) baseline versus TEM: 7.69 % HIp and 7.69 % HOSp; (C) HFM versus TEM: 15.38 % HIp and 15.38 % HOSp.
   TEM reduced postprandial risk factors of CVD, such as ox-LDL, and the expression of inflammation and oxidative stress-related genes. Chronic studies on larger population are necessary before definitive conclusions.
   ClinicalTrials.gov Id: NCT01890070.
C1 [De Lorenzo, Antonino; Gualtieri, Paola; Di Renzo, Laura] Univ Roma Tor Vergata, Div Clin Nutr & Nutrigen, Dept Biomed & Prevent, I-00133 Rome, Italy.
   [Bernardini, Sergio; Perrone, Marco Alfonso] Univ Roma Tor Vergata, Div Clin Biochem & Clin Mol Biol, Rome, Italy.
   [Cabibbo, Andrea] Univ Roma Tor Vergata, Dept Biol, Rome, Italy.
   [Perrone, Marco Alfonso] Univ Roma Tor Vergata, Div Cardiol, I-00133 Rome, Italy.
   [Giambini, Ilio] Tor Vergata Univ Hosp, Rome, Italy.
C3 University of Rome Tor Vergata; University of Rome Tor Vergata;
   University of Rome Tor Vergata; University of Rome Tor Vergata;
   University of Rome Tor Vergata; Policlin Tor Vergata
RP De Lorenzo, A (corresponding author), Univ Roma Tor Vergata, Div Clin Nutr & Nutrigen, Dept Biomed & Prevent, I-00133 Rome, Italy.
EM delorenzo@uniroma2.it
RI Di Renzo, Laura/ACB-2003-2022; Cabibbo, Andrea/ABH-6051-2022; Gualtieri,
   Paola/AAS-1684-2020
OI De Lorenzo, Antonino/0000-0001-6524-4493; di renzo,
   laura/0000-0001-8875-6723; Gualtieri, Paola/0000-0003-1533-4276
FU Ministry of Agriculture, Food and Forestry [2017188]
FX This study was supported by grants from Ministry of Agriculture, Food
   and Forestry (D.M.; 2017188).
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NR 44
TC 55
Z9 56
U1 2
U2 14
PU SPRINGER-VERLAG ITALIA SRL
PI MILAN
PA VIA DECEMBRIO, 28, MILAN, 20137, ITALY
SN 0940-5429
EI 1432-5233
J9 ACTA DIABETOL
JI Acta Diabetol.
PD FEB
PY 2017
VL 54
IS 2
BP 141
EP 149
DI 10.1007/s00592-016-0917-2
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA EK9IB
UT WOS:000394236400004
PM 27709360
DA 2025-06-11
ER

PT J
AU Pomari, E
   Stefanon, B
   Colitti, M
AF Pomari, Elena
   Stefanon, Bruno
   Colitti, Monica
TI Effects of Two Different Rhodiola rosea Extracts on Primary Human
   Visceral Adipocytes
SO MOLECULES
LA English
DT Article
DE human visceral adipocytes; differentiation; gene expression; Rhodiola
   rosea
ID TO-MODERATE DEPRESSION; PPAR-GAMMA; PROMOTES ADIPOGENESIS; TRANSCRIPTION
   FACTORS; METABOLIC SYNDROME; SIGNALING PATHWAY; ADIPOSE-TISSUE;
   YERBA-MATE; RAT MODEL; SALIDROSIDE
AB Rhodiola rosea (Rro) has been reported to have various pharmacological properties, including anti-fatigue, anti-stress and anti-inflammatory activity. It is also known to improve glucose and lipid metabolism, but the effects of Rhodiola rosea on adipocyte differentiation and metabolism are not still elucidated. In this study the anti-adipogenic and lipolytic activity of two extracts of Rhodiola rosea, containing 3% salidroside (RS) or 1% salidroside and 3% rosavines (RR) on primary human visceral adipocytes was investigated. Pre-adipocytes were analyzed after 10 and 20 days of treatment during differentiation and after 7 days of treatment when they reached mature shape. The RS extract significantly induced higher apoptosis and lipolysis in comparison to control cells and to RR extract. In contrast, RR extract significantly reduced triglyceride incorporation during maturation. Differentiation of pre-adipocytes in the presence of RS and RR extracts showed a significant decrease in expression of genes involved in adipocyte function such as SLC2A4 and the adipogenic factor FGF2 and significant increase in expression of genes involved in inhibition of adipogenesis, such as GATA3, WNT3A, WNT10B. Furthermore RR extract, in contrast to RS, significantly down-regulates PPARG, the master regulator of adipogenesis and FABP4. These data support the lipolytic and anti-adipogenetic activity of two different commercial extracts of Rhodiola rosea in primary human visceral pre-adipocytes during differentiation.
C1 [Pomari, Elena; Stefanon, Bruno; Colitti, Monica] Univ Udine, Dept Agr & Environm Sci, I-33100 Udine, Italy.
C3 University of Udine
RP Colitti, M (corresponding author), Univ Udine, Dept Agr & Environm Sci, Via Sci 206, I-33100 Udine, Italy.
EM elena.pomari@gmail.com; bruno.stefanon@uniud.it; monica.colitti@uniud.it
RI Stefanon, Bruno/J-1820-2019; Pomari, Elena/J-8184-2018
OI colitti, monica/0000-0002-1775-3880; Pomari, Elena/0000-0002-5182-0231;
   stefanon, bruno/0000-0002-7414-5830
FU  [ART. 13 D.LGS 297/99]
FX This work was supported by Progetto ART. 13 D.LGS 297/99, Italy.
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NR 84
TC 27
Z9 30
U1 0
U2 36
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1420-3049
J9 MOLECULES
JI Molecules
PD MAY
PY 2015
VL 20
IS 5
BP 8409
EP 8428
DI 10.3390/molecules20058409
PG 20
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA CL7NA
UT WOS:000357157600058
PM 25970041
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Iceta, S
   Dadar, M
   Daoust, J
   Scovronec, A
   Leblanc, V
   Pelletier, M
   Biertho, L
   Tchernof, A
   Bégin, C
   Michaud, A
AF Iceta, Sylvain
   Dadar, Mahsa
   Daoust, Justine
   Scovronec, Anais
   Leblanc, Vicky
   Pelletier, Melissa
   Biertho, Laurent
   Tchernof, Andre
   Begin, Catherine
   Michaud, Andreanne
TI Association between Visceral Adiposity Index, Binge Eating Behavior, and
   Grey Matter Density in Caudal Anterior Cingulate Cortex in Severe
   Obesity
SO BRAIN SCIENCES
LA English
DT Article
DE binge eating behavior; grey matter density; severe obesity; metabolic
   disorders; visceral adiposity; emotion regulation
ID TO-HEIGHT RATIO; CARDIOMETABOLIC RISK-FACTORS; BODY-FAT DISTRIBUTION;
   MASS INDEX; MEDICAL COMORBIDITY; WAIST CIRCUMFERENCE; DOMAIN CRITERIA;
   WEIGHT-LOSS; DISORDER; IMPULSIVITY
AB Visceral adipose tissue accumulation is an important determinant of metabolic risk and can be estimated by the visceral adiposity index (VAI). Visceral adiposity may impact brain regions involved in eating behavior. We aimed to examine the association between adiposity measurements, binge eating behavior, and grey matter density. In 20 men and 59 women with severe obesity, Grey matter density was measured by voxel-based morphometry for six regions of interest associated with reward, emotion, or self-regulation: insula, orbitofrontal cortex, caudal and rostral anterior cingulate cortex (ACC), ventromedial prefrontal cortex (vmPFC), and dorsolateral prefrontal cortex (DLPFC). Binge eating behavior, depression and impulsivity was assessed by the Binge Eating Scale, Beck Depression Inventory and UPPS Impulsive Behavior Scale, respectively. Men and women were distinctively divided into two subgroups (low-VAI and high-VAI) based on the mean VAI score. Women with high-VAI were characterized by metabolic alterations, higher binge eating score and lower grey matter density in the caudal ACC compared to women with low-VAI. Men with high-VAI were characterized by a higher score for the sensation-seeking subscale of the UPPS-Impulsive Behavior Scale compared to men with low-VAI. Using a moderation-mediation analysis, we found that grey matter density in the caudal ACC mediates the association between VAI and binge eating score. In conclusion, visceral adiposity is associated with higher binge eating severity in women. Decreased grey matter density in the caudal ACC, a region involved in cognition and emotion regulation, may influence this relationship.
C1 [Iceta, Sylvain; Daoust, Justine; Scovronec, Anais; Pelletier, Melissa; Tchernof, Andre; Begin, Catherine; Michaud, Andreanne] Univ Laval, Res Ctr, Quebec Heart & Lung Inst, Quebec City, PQ G1V 4G5, Canada.
   [Iceta, Sylvain; Daoust, Justine; Scovronec, Anais; Tchernof, Andre; Michaud, Andreanne] Univ Laval, Sch Nutr, Quebec City, PQ G1V 0A6, Canada.
   [Dadar, Mahsa] Univ Laval, Ctr Integre Univ Sante & Serv Sociaux Capitale Na, CERVO Brain Res Ctr, Quebec City, PQ GM 1T2, Canada.
   [Leblanc, Vicky; Begin, Catherine; Michaud, Andreanne] Univ Laval, Ctr Nutr Sante & Soc NUTRISS, Inst Sur Nutr & Aliments Fonct INAF, Quebec City, PQ, Canada.
   [Biertho, Laurent] Univ Laval, Quebec Heart & Lung Inst, Dept Chirurg Gen, Quebec City, PQ G1V 4G5, Canada.
   [Begin, Catherine] Univ Laval, Sch Psychol, Quebec City, PQ G1V 0A6, Canada.
C3 Laval University; Quebec Heart & Lung Institute; Laval University; Laval
   University; Laval University; Quebec Heart & Lung Institute; Laval
   University; Laval University
RP Iceta, S; Michaud, A (corresponding author), Univ Laval, Sch Nutr, Quebec City, PQ G1V 0A6, Canada.; Michaud, A (corresponding author), Univ Laval, Ctr Nutr Sante & Soc NUTRISS, Inst Sur Nutr & Aliments Fonct INAF, Quebec City, PQ, Canada.
EM sylvain.iceta.1@ulaval.ca; mahsa.dadar.1@ulaval.ca;
   justine.daoust.1@ulaval.ca; anais.scovronec.1@ulaval.ca;
   vickyleblanc@fsaa.ulaval.ca; melissa.pelletier@criucpq.ulaval.ca;
   laurentbiertho@gmail.com; andre.tchernof@criucpq.ulaval.ca;
   catherine.begin@psy.ulaval.ca; Andreanne.michaud@criucpq.ulaval.ca
RI Iceta, Sylvain/AAX-2870-2020
OI ICETA, Sylvain/0000-0002-0054-1865; Daoust, Justine/0000-0002-3528-263X;
   Dadar, Mahsa/0000-0003-4008-2672; Tchernof, Andre/0000-0002-2587-1000;
   Michaud, Andreanne/0000-0003-2028-8307
FU Canadian Institutes of Health Research (CIHR) [TB2-138776]; Johnson &
   Johnson Medical Companies [ETH-14-610]
FX This study is supported by a team grant from the Canadian Institutes of
   Health Research (CIHR) on bariatric care (TB2-138776) and an
   investigator-initiated study grant from Johnson & Johnson Medical
   Companies (Grant ETH-14-610, REMISSION Study). Funding sources for the
   trial had no role in the design, conduction, or management of the study,
   in data collection, analysis or interpretation, in the preparation of
   the present manuscript and decision to publish. The coinvestigators and
   collaborators of the REMISSION study are (alphabetical order): Begin C,
   Biertho L, Bouvier M, Biron S, Cani P, Carpentier A, Dagher A, Dube F,
   Fergusson A, Fulton S, Hould FS, Julien F, Kieffer T, Laferrere B,
   Lafortune A, Lebel S, Lescelleur O, Levy E, Marette A, Marceau S,
   Michaud A, Picard F, Poirier P, Richard D, Schertzer J, Tchernof A, and
   Vohl MC. S.I. is supported by Fonds Germain-Brisson, Faculte des
   sciences de l'agriculture et de l'alimentation, Universite Laval,
   postdoctoral award.
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NR 79
TC 9
Z9 9
U1 2
U2 11
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3425
J9 BRAIN SCI
JI Brain Sci.
PD SEP
PY 2021
VL 11
IS 9
AR 1158
DI 10.3390/brainsci11091158
PG 17
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology
GA UV0VL
UT WOS:000699207600001
PM 34573180
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Kim, H
   Moon, SY
   Kim, JS
   Baek, CH
   Kim, M
   Min, JY
   Lee, SK
AF Kim, Hyosang
   Moon, Soo Young
   Kim, Joon-Seok
   Baek, Chung Hee
   Kim, Miyeon
   Min, Ji Yeon
   Lee, Sang Koo
TI Activation of AMP-activated protein kinase inhibits ER stress and renal
   fibrosis
SO AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
LA English
DT Article
DE AMP-activated protein kinase; endoplasmic reticulum stress; fibrosis;
   heme oxygenase-1; metformin
ID ENDOPLASMIC-RETICULUM STRESS; HEME OXYGENASE-1; URETERAL OBSTRUCTION;
   METABOLIC SYNDROME; LIVER FIBROSIS; EXPRESSION; KIDNEY; INJURY; MICE;
   DISEASE
AB It has been suggested that endoplasmic reticulum (ER) stress facilitates fibrotic remodeling. Therefore, modulation of ER stress may serve as one of the possible therapeutic approaches to renal fibrosis. We examined whether and how activation of AMP-activated protein kinase (AMPK) suppressed ER stress induced by chemical ER stress inducers [tunicamycin (TM) and thapsigargin (TG)] and also nonchemical inducers in tubular HK-2 cells. We further investigated the in vivo effects of AMPK on ER stress and renal fibrosis. Western blot analysis, immunofluorescence, small interfering (si) RNA experiments, and immunohistochemical staining were performed. Metformin (the best known clinical activator of AMPK) suppressed TM- or TG-induced ER stress, as shown by the inhibition of TM- or TG-induced upregulation of glucose-related protein (GRP) 78 and phosphorylated eukaryotic initiation factor-2 alpha through induction of heme oxygenase-1. Metformin inhibited TM- or TG-induced epithelial-mesenchymal transitions as well. Compound C (AMPK inhibitor) blocked the effect of metformin, and 5-aminoimidazole-4-carboxamide-1 beta riboside (another AMPK activator) exerted the same effects as metformin. Transfection with siRNA targeting AMPK blocked the effect of metformin. Consistent with the results of cell culture experiments, metformin reduced renal cortical GRP78 expression and increased heme oxygenase-1 expression in a mouse model of ER stress-induced acute kidney injury by TM. Activation of AMPK also suppressed ER stress by transforming growth factor-beta, ANG II, aldosterone, and high glucose. Furthermore, metformin reduced GRP78 expression and renal fibrosis in a mouse model of unilateral ureteral obstruction. In conclusion, AMPK may serve as a promising therapeutic target through reducing ER stress and renal fibrosis.
C1 [Kim, Hyosang; Moon, Soo Young; Kim, Joon-Seok; Baek, Chung Hee; Kim, Miyeon; Min, Ji Yeon; Lee, Sang Koo] Univ Ulsan, Asan Inst Life Sci, Asan Med Ctr, Dept Internal Med, Seoul, South Korea.
C3 University of Ulsan; Asan Medical Center
RP Lee, SK (corresponding author), Asan Med Ctr, Dept Internal Med, Div Nephrol, 88,Olymp Ro 43 Gil, Seoul 138736, South Korea.
EM sklee2@amc.seoul.kr
RI Kim, Miyeon/JDM-6570-2023
FU Asan Institute for Life Sciences, Asan Medical Center
FX This work was supported by a grant from the Asan Institute for Life
   Sciences, Asan Medical Center, (to C. L. Lee and K. Y. Son).
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NR 50
TC 120
Z9 132
U1 0
U2 24
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 1931-857X
EI 1522-1466
J9 AM J PHYSIOL-RENAL
JI Am. J. Physiol.-Renal Physiol.
PD FEB 1
PY 2015
VL 308
IS 3
BP F226
EP F236
DI 10.1152/ajprenal.00495.2014
PG 11
WC Physiology; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology; Urology & Nephrology
GA CB0BV
UT WOS:000349290600005
PM 25428127
DA 2025-06-11
ER

PT J
AU Mao, JY
   Ge, YB
   Wang, HH
   Qiang, W
   Yun, Z
   Yu, DL
   Zhang, Y
   Huang, Q
   Zhao, ZQ
   Zhao, GF
   Wang, ZW
   Ma, XP
   Zhang, ZP
   Li, M
   Shao, L
   Zhao, CY
AF Mao Jing-yuan
   Ge Yong-bin
   Wang Heng-he
   Qiang, Wang
   Yun, Zhang
   Yu Dong-ling
   Zhang Yu
   Huang Qi
   Zhao Zhi-qiang
   Zhao Gui-feng
   Wang Zhan-wu
   Ma Xue-peng
   Zhang Zhen-peng
   Li Ming
   Shao Lei
   Zhao Chun-yan
TI Summary of 32 patients with cardiac syndrome X treated by TCM therapy of
   regulating qi relieving chest stuffiness and promoting blood circulation
SO CHINESE JOURNAL OF INTEGRATIVE MEDICINE
LA English
DT Article
DE cardiac syndrome X; qi stagnation; phlegm obstruction and blood stasis;
   regulating qi; relieving chest stuffiness and promoting blood
   circulation method
ID HEART
AB Objective: To evaluate the clinical effect of Liqi Kuanxiong Huoxue method, LKH, traditional Chinese medicine, TCM therapeutic method for regulating qi, relieving chest stuffiness and promoting blood circulation) in treating patients with cardiac syndrome X (CSX). Methods: The prospective, non-randomized controlled study was conducted on 51 selected patients with CSX, who were non-randomly assigned to 2 groups, the treated group treated with LKH in addition to the conventional treatment (32 patients), and the control group treated with conventional treatment (19 patients) like nitrate, diltiazem hydrochloride, etc. The treatment course was 14 days. The changes of such symptoms as angina pectoris, TCM syndrome and indexes of treadmill exercise test before and after treatment were observed. Results: After treatment, such symptoms as chest pain and stuffy feeling and palpitation in the treated group were improved more than those in the control group (P<0.05); the total effective rate on angina pectoris and TCM syndrome in the treated group was better than that in the control group (P<0.05). The treadmill exercise test showed that the maximal metabolic equivalent (Max MET), the time of angina onset and ST segment depression by 0.1 mV were obviously improved after treatment in both groups, but the improvement in the treated group was better than that in the control group respectively (P<0.05). Conclusion: The LKH method could reduce the frequency of angina attacks and improve the clinical condition of patients with CSX.
C1 [Mao Jing-yuan; Ge Yong-bin; Wang Heng-he; Qiang, Wang; Yun, Zhang; Yu Dong-ling; Zhang Yu; Huang Qi; Zhao Zhi-qiang; Zhao Gui-feng; Wang Zhan-wu; Ma Xue-peng; Shao Lei; Zhao Chun-yan] Tianjin Univ Tradit Chinese Med, Teaching Hosp 1, Cardiovasc Dept, Tianjin 300193, Peoples R China.
   [Zhang Zhen-peng] Guanganmen Hosp, China Acad Chinese Med Sci, Tianjin, Peoples R China.
C3 Tianjin University of Traditional Chinese Medicine; China Academy of
   Chinese Medical Sciences
RP Mao, JY (corresponding author), Tianjin Univ Tradit Chinese Med, Teaching Hosp 1, Cardiovasc Dept, Tianjin 300193, Peoples R China.
EM jymao@263.net
RI yang, yang/HGT-7999-2022; zhao, zhiqiang/K-2029-2014; Li,
   Ming/GLV-0336-2022; Wang, Zhanwu/MTF-6534-2025
CR Ali O, 2001, Curr Atheroscler Rep, V3, P149, DOI 10.1007/s11883-001-0051-6
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NR 13
TC 6
Z9 6
U1 0
U2 22
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1672-0415
EI 1993-0402
J9 CHIN J INTEGR MED
JI Chin. J. Integr. Med.
PD MAR
PY 2007
VL 13
IS 1
BP 17
EP 21
DI 10.1007/s11655-007-0017-9
PG 5
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA 274NS
UT WOS:000254008600005
PM 17578312
DA 2025-06-11
ER

PT J
AU Afonso, MS
   Silva, AMD
   Carvalho, EBT
   Rivelli, DP
   Barros, SBM
   Rogero, MM
   Lottenberg, AM
   Torres, RP
   Mancini, J
AF Afonso, Milessa S.
   Silva, Ana Mara de O.
   Carvalho, Eliane B. T.
   Rivelli, Diogo P.
   Barros, Silvia B. M.
   Rogero, Marcelo M.
   Lottenberg, Ana Maria
   Torres, Rosangela P.
   Mancini-Filho, Jorge
TI Phenolic compounds from Rosemary (Rosmarinus officinalis L.)
   attenuate oxidative stress and reduce blood cholesterol concentrations
   in diet-induced hypercholesterolemic rats
SO NUTRITION & METABOLISM
LA English
DT Article
DE Hypercholesterolemia; Oxidative stress; Polyphenols; Rosmarinus
   officinalis
ID PLASMA-LIPID LEVELS; ANTIOXIDANT ACTIVITY; REACTIVE OXYGEN; DISEASE;
   ATHEROSCLEROSIS; MECHANISMS; EXTRACT; RICH; PURIFICATION; INFLAMMATION
AB Background: Phenolic compounds combine antioxidant and hypocholesterolemic activities and, consequently, are expected to prevent or minimize cardiometabolic risk.
   Methods: To evaluate the effect of an aqueous extract (AQ) and non-esterified phenolic fraction (NEPF) from rosemary on oxidative stress in diet-induced hypercholesterolemia, 48 male 4-week old Wistar rats were divided into 6 groups: 1 chow diet group (C) and 5 hypercholesterolemic diet groups, with 1 receiving water (HC), 2 receiving AQ at concentrations of 7 and 140 mg/kg body weight (AQ70 and AQ140, respectively), and 2 receiving NEPF at concentrations of 7 and 14 mg/kg body weight (NEPF7 and NEPF14, respectively) by gavage for 4 weeks.
   Results: In vitro, both AQ and NEPF had remarkable antioxidant activity in the 2,2-diphenyl-1-picrylhydrazyl (DPPH center dot) assay, which was similar to BHT. In vivo, the group that received AQ at 70 mg/kg body weight had lower serum total cholesterol (-39.8%), non-HDL-c (-44.4%) and thiobarbituric acid reactive substance (TBARS) levels (-37.7%) compared with the HC group. NEPF (7 and 14 mg/kg) reduced the tissue TBARS levels and increased the activity of tissular antioxidant enzymes (superoxide dismutase, catalase and glutathione peroxidase). Neither AQ nor NEPF was able to ameliorate the alterations in the hypercholesterolemic diet-induced fatty acid composition in the liver.
   Conclusions: These data suggest that phenolic compounds from rosemary ameliorate the antioxidant defense in different tissues and attenuate oxidative stress in diet-induced hypercholesterolemic rats, whereas the serum lipid profile was improved only in rats that received the aqueous extract.
C1 [Afonso, Milessa S.; Silva, Ana Mara de O.; Carvalho, Eliane B. T.; Torres, Rosangela P.; Mancini-Filho, Jorge] Univ Sao Paulo, Fac Pharmaceut Sci, Dept Food & Expt Nutr, BR-05508900 Sao Paulo, Brazil.
   [Rivelli, Diogo P.; Barros, Silvia B. M.] Univ Sao Paulo, Fac Pharmaceut Sci, Dept Clin & Toxicol Anal, BR-05508900 Sao Paulo, Brazil.
   [Rogero, Marcelo M.] Univ Sao Paulo, Sch Publ Hlth, Dept Nutr, BR-01246904 Sao Paulo, Brazil.
   [Afonso, Milessa S.; Lottenberg, Ana Maria] Univ Sao Paulo, Fac Med Sci, Lipids Lab LIM 10, BR-01246000 Sao Paulo, Brazil.
C3 Universidade de Sao Paulo; Universidade de Sao Paulo; Universidade de
   Sao Paulo; Universidade de Sao Paulo
RP Afonso, MS (corresponding author), Univ Sao Paulo, Fac Pharmaceut Sci, Dept Food & Expt Nutr, BR-05508900 Sao Paulo, Brazil.
EM milessa_afonso@yahoo.com.br
RI Lottenberg, Ana/N-2531-2017; Mancini-Filho, Jorge/F-3950-2018; Barros,
   Silvia/H-1090-2012; Rogero, Marcelo/T-9025-2019; Rivelli,
   Diogo/B-3199-2015; Afonso, Milessa/J-2078-2014; Berlanga de Moraes
   Barros, Silvia/K-6856-2014
OI Macedo Rogero, Marcelo/0000-0003-0517-1645; Pineda Rivelli,
   Diogo/0000-0002-5054-962X; Afonso, Milessa/0000-0003-3435-0722; Berlanga
   de Moraes Barros, Silvia/0000-0003-3427-4440; Silva,
   Ana/0000-0003-0831-8833
FU Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP), Brazil
   [08/51333-1, 08/54319-0]
FX This investigation was supported by grants 08/51333-1 (Afonso MS) and
   08/54319-0 (Mancini-Filho, J) from the Fundacao de Amparo a Pesquisa do
   Estado de Sao Paulo (FAPESP), Brazil. We would like to thank Gabriela
   Castilho for helping with the language revision. All authors read and
   approved the final manuscript.
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NR 43
TC 99
Z9 108
U1 1
U2 58
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1743-7075
J9 NUTR METAB
JI Nutr. Metab.
PD FEB 2
PY 2013
VL 10
AR 19
DI 10.1186/1743-7075-10-19
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 099QW
UT WOS:000315637300001
PM 23374457
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Kacarevic, D
   Bogavac-Stanojevic, N
   Spasojevic-Kalimanovska, V
   Bojanin, D
   Milenkovic, T
   Stefanovic, A
   Mihajlovic, M
   Vujcic, S
   Vukovic, R
   Zeljkovic, A
   Todorovic, S
   Mitrovic, K
   Vekic, J
AF Kacarevic, Dragana
   Bogavac-Stanojevic, Natasa
   Spasojevic-Kalimanovska, Vesna
   Bojanin, Dragana
   Milenkovic, Tatjana
   Stefanovic, Aleksandra
   Mihajlovic, Marija
   Vujcic, Sanja
   Vukovic, Rade
   Zeljkovic, Aleksandra
   Todorovic, Sladjana
   Mitrovic, Katarina
   Vekic, Jelena
TI Factors associated with oxidative stress status in pediatric patients
   with type 1 diabetes mellitus
SO JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
LA English
DT Article
DE antioxidants; biomarkers; cardiometabolic factors; children; oxidative
   damage
ID PROOXIDANT-ANTIOXIDANT BALANCE; GELATINASE-ASSOCIATED LIPOCALIN;
   CHILDREN; DYSLIPIDEMIA; HOMEOSTASIS; ADOLESCENTS; RISK
AB Background: Oxidative stress is implicated in both, the onset and the progression of type 1 diabetes mellitus (T1DM). There is accumulated evidence of increased biomarkers of oxidative stress in newly diagnosed, T1DM patients without complications, and in those with advanced disease. In this cross-sectional study, we investigated factors affecting oxidative stress status in pediatric patients with T1DM.
   Methods: Advanced oxidation protein products (AOPP), prooxidant-antioxidant balance (PAB), total sulfhydryl (SH) groups, and superoxide dismutase (SOD) activity were determined in 170 children and adolescents with T1DM. Principal component analysis was used to investigate clustering of clinical and laboratory variables associated with elevated oxidative stress and reduced antioxidative defense biomarkers.
   Results: Factor analysis extracted five factors, interpreted as (1) "weight status factor" including age, BMI, waist and hip circumferences; (2) "proatherogenic factor" that included LDL-cholesterol, non-HDL-cholesterol, and triglycerides; (3) "metabolic control factor" including glucose and HbA(1c); (4) "renal marker factor" with positive loading of urinary albumin excretion rate and negative loading of GFR; and (5) "antiatherogenic factor" that included HDL-cholesterol. High AOPP levels were independently predicted by "proatherogenic" (OR: 2.32; 95% CI: 1.44-3.71; p <0.001), "metabolic control" (OR: 2.24; 95% CI: 1.35-3.73; p <0.01), and "renal marker" (OR: 1.65; 95% CI: 1.03-2.65; p <0.05) factors. "Renal marker factor" was a significant predictor of PAB (OR: 0.52; 95% CI: 0.34-0.81; p <0.01). Regarding antioxidative defense markers, reduced SH groups were predicted by "proatherogenic factor" (OR: 0.56; 95% CI: 0.34 0.94; p <0.05), while "weight status factor" predicted lower SOD activity (OR: 1.66; 95% CI: 1.03-2.67; p <0.05).
   Conclusions: Cardiometabolic risk factors and renal function are associated with oxidative stress in pediatric T1DM patients.
C1 [Kacarevic, Dragana; Bogavac-Stanojevic, Natasa; Spasojevic-Kalimanovska, Vesna; Stefanovic, Aleksandra; Mihajlovic, Marija; Vujcic, Sanja; Zeljkovic, Aleksandra; Vekic, Jelena] Univ Belgrade, Fac Pharm, Dept Med Biochem, Vojvode Stepe 450,P Box 146, Belgrade 11000, Serbia.
   [Bojanin, Dragana] Mother & Child Hlth Care Inst Serbia Dr Vukan Cup, Biochem Lab, Dept Clin Chem & Hematol, Belgrade, Serbia.
   [Milenkovic, Tatjana; Vukovic, Rade; Todorovic, Sladjana; Mitrovic, Katarina] Mother & Child Hlth Care Inst Serbia Dr Vukan Cup, Dept Endocrinol, Belgrade, Serbia.
   [Vukovic, Rade] Univ Belgrade, Sch Med, Belgrade, Serbia.
C3 University of Belgrade; University of Belgrade
RP Vujcic, S (corresponding author), Univ Belgrade, Fac Pharm, Dept Med Biochem, Vojvode Stepe 450,P Box 146, Belgrade 11000, Serbia.
EM svujcic@pharmacy.bg.ac.rs
RI Todorovic, Sladjana/GVS-4184-2022; Vukovic, Rade/H-3344-2019
OI Vukovic, Rade/0000-0002-1592-4105; Vujcic, Sanja/0000-0002-5557-1850;
   Vekic, Jelena/0000-0001-7445-0504; Zeljkovic,
   Aleksandra/0000-0001-6417-8404; Stefanovic,
   Aleksandra/0000-0002-0331-6807
FU Ministry of Education, Science and Technological Development, Republic
   of Serbia
FX Ministry of Education, Science and Technological Development, Republic
   of Serbia.
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NR 36
TC 5
Z9 5
U1 0
U2 3
PU WALTER DE GRUYTER GMBH
PI BERLIN
PA GENTHINER STRASSE 13, D-10785 BERLIN, GERMANY
SN 0334-018X
EI 2191-0251
J9 J PEDIATR ENDOCR MET
JI J. Pediatr. Endocrinol. Metab.
PD MAY
PY 2020
VL 33
IS 5
BP 591
EP 598
DI 10.1515/jpem-2019-0555
PG 8
WC Endocrinology & Metabolism; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Pediatrics
GA LS1FH
UT WOS:000536137100003
PM 32229673
DA 2025-06-11
ER

PT J
AU Genario, R
   Cipolla-Neto, J
   Bueno, AA
   Santos, HO
AF Genario, Rafael
   Cipolla-Neto, Jose
   Bueno, Allain A.
   Santos, Heitor O.
TI Melatonin supplementation in the management of obesity and
   obesity-associated disorders: A review of physiological mechanisms and
   clinical applications
SO PHARMACOLOGICAL RESEARCH
LA English
DT Review
DE Obesity therapy; Weight loss; Melatonin; Obesity; Endocrinology
ID RABSON-MENDENHALL SYNDROME; WHITE ADIPOSE-TISSUE; OXIDATIVE STRESS;
   DOUBLE-BLIND; METABOLIC SYNDROME; GLUCOSE-TOLERANCE; MAJOR DEPRESSION;
   BLOOD-PRESSURE; LIPID PROFILE; ADULT OBESITY
AB Despite the evolving advances in clinical approaches to obesity and its inherent comorbidities, the therapeutic challenge persists. Among several pharmacological tools already investigated, recent studies suggest that melatonin supplementation could be an efficient therapeutic approach in the context of obesity. In the present review, we have amalgamated the evidence so far available on physiological effects of melatonin supplementation in obesity therapies, addressing its effects upon neuroendocrine systems, cardiometabolic biomarkers and body composition. Most studies herein appraised employed melatonin supplementation at dosages ranging from 1 to 20 mg/day, and most studies followed up participants for periods from 3 weeks to 12 months. Overall, it was observed that melatonin plays an important role in glycaemic homeostasis, in addition to modulation of white adipose tissue activity and lipid metabolism, and mitochondrial activity. Additionally, melatonin increases brown adipose tissue volume and activity, and its antioxidant and anti-inflammatory properties have also been demonstrated. There appears to be a role for melatonin in adiposity reduction; however, several questions remain unanswered, for example melatonin baseline levels in obesity, and whether any seeming hypomelatonaemia or melatonin irresponsiveness could be clarifying factors. Supplementation dosage studies and more thorough clinical trials are needed to ascertain not only the relevance of such findings but also the efficacy of melatonin supplementation.
C1 [Genario, Rafael] Univ Sao Paulo, Sch Med, Sao Paulo, Brazil.
   [Cipolla-Neto, Jose] Univ Sao Paulo, Inst Biomed Sci, Dept Physiol & Biophys, Sao Paulo, Brazil.
   [Bueno, Allain A.] Univ Worcester, Coll Hlth Life & Environm Sci, Worcester, England.
   [Santos, Heitor O.] Fed Univ Uberlandia UFU, Sch Med, Uberlandia, MG, Brazil.
C3 Universidade de Sao Paulo; Universidade de Sao Paulo; Institute Biomed
   Science, University Sao Paulo; University of Worcester; Universidade
   Federal de Uberlandia
RP Genario, R (corresponding author), Univ Sao Paulo, Av Dr Arnaldo 455, BR-01246903 Sao Paulo, SP, Brazil.; Santos, HO (corresponding author), Fed Univ Uberlandia UFU, Av Para 1720, BR-38400902 Uberlandia, MG, Brazil.
EM rafagenario@gmail.com; heitoroliveirasantos@gmail.com
RI Genario, Rafael/W-8260-2019; Cipolla-Neto, Jose/B-1619-2009
OI Cipolla-Neto, Jose/0000-0003-3748-3731; Bueno,
   Allain/0000-0002-9456-8558; Genario, Rafael/0000-0001-8132-8769
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NR 161
TC 30
Z9 34
U1 0
U2 21
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 1043-6618
EI 1096-1186
J9 PHARMACOL RES
JI Pharmacol. Res.
PD JAN
PY 2021
VL 163
AR 105254
DI 10.1016/j.phrs.2020.105254
EA JAN 2021
PG 10
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA PU3TD
UT WOS:000609226800031
PM 33080320
OA Green Accepted
DA 2025-06-11
ER

PT J
AU de Donato, A
   Buonincontri, V
   Borriello, G
   Martinelli, G
   Mone, P
AF de Donato, Antonio
   Buonincontri, Veronica
   Borriello, Gianmarco
   Martinelli, Giuseppe
   Mone, Pasquale
TI The Dopamine System: Insights between Kidney and Brain
SO KIDNEY & BLOOD PRESSURE RESEARCH
LA English
DT Review
DE Dopamine; Chronic kidney disease; Brain; Older adults
ID CHRONIC-RENAL-FAILURE; K-ATP CHANNEL; VOLUME TRANSMISSION; AMINO-ACID;
   SECRETORY GRANULES; OXIDATIVE STRESS; KV7 CHANNELS; URIC-ACID;
   HISTAMINE; RELEASE
AB Background: Chronic kidney disease (CKD) is one of the most common diseases in adult age, and it is typical of older adults. Recent data suggest that almost half of the elders have CKD. It is now clear that CKD is accompanied, in the early stages, by cognitive impairment, together with depression and subtle abnormalities in motor control (such as gait and balance alterations). Summary: Several data suggest a link between brain dopamine and kidney diseases. Metabolic syndrome and diabetes can affect dopamine neuron survival (leading to Parkinson's disease). Several uremic toxins in CKD (uric acid, indoxyl sulfate) and trace elements accumulating in CKD (aluminum, manganese) can also modify the dopaminergic system. Hormones produced by the kidney such as vitamin D are neuroprotective for dopamine neurons. Dopaminergic drugs are useful for the treatment of a common sleep disorder in CKD, the restless legs syndrome. However, experiments on animal models of CKD show conflicting results regarding a modification of dopamine neurons. Key Messages: Several observations suggest a limited relevance of the dopaminergic system in CKD-related cognitive impairment. However, a common sleep disturbance in CKD, the restless legs syndrome, improves with dopaminergic drugs. Therefore, it remains to be established the role of the dopamine system in subtle motor dysfunction observed in CKD, such as tremors, gait alterations, and central sleep apnea.
C1 [de Donato, Antonio; Buonincontri, Veronica; Borriello, Gianmarco; Martinelli, Giuseppe; Mone, Pasquale] Univ Campania Luigi Vanvitelli, Dipartimento Salute Mentale Fis & Med Prevent, Naples, Italy.
   [Martinelli, Giuseppe] ASL Napoli, Naples, Italy.
   [Mone, Pasquale] ASL Avellino, Avellino, Italy.
C3 Universita della Campania Vanvitelli
RP Mone, P (corresponding author), Univ Campania Luigi Vanvitelli, Dipartimento Salute Mentale Fis & Med Prevent, Naples, Italy.; Mone, P (corresponding author), ASL Avellino, Avellino, Italy.
EM pasqualemone@hotmail.it
RI de Donato, Antonio/GVU-4993-2022; Mone, Pasquale/LSK-3879-2024;
   Buonincontri, Veronica/GWU-8877-2022
OI de Donato, Antonio/0000-0001-6412-9960; , Veronica
   Buonincontri/0000-0002-9112-9437
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NR 178
TC 17
Z9 18
U1 0
U2 18
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1420-4096
EI 1423-0143
J9 KIDNEY BLOOD PRESS R
JI Kidney Blood Pressure Res.
PD AUG
PY 2022
VL 47
IS 8
BP 493
EP 505
DI 10.1159/000522132
PG 13
WC Physiology; Urology & Nephrology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology; Urology & Nephrology; Cardiovascular System & Cardiology
GA 3X1MT
UT WOS:000842808700001
PM 35378538
OA gold
DA 2025-06-11
ER

PT J
AU Sun, YK
   Liu, HY
   Mu, CG
   Liu, PP
   Hao, CF
   Xin, YJ
AF Sun, Yukun
   Liu, Haiyan
   Mu, Chunguang
   Liu, Peipei
   Hao, Changfu
   Xin, Yongjuan
TI Early puberty: a review on its role as a risk factor for metabolic and
   mental disorders
SO FRONTIERS IN PEDIATRICS
LA English
DT Review
DE early puberty; obesity; diabetes; cardiovascular diseases; behavioral
   dysfunction; depression
ID BODY-MASS-INDEX; CARDIOMETABOLIC RISK; PREMENOPAUSAL WOMEN; SECULAR
   TRENDS; EARLY MENARCHE; AGE; ASSOCIATION; VIOLENCE; VICTIMIZATION;
   CHILDHOOD
AB Accumulating evidence indicates that there is a trend of early puberty onset in humans. The early timing of puberty has raised concerns due to its association with significant negative health outcomes. However, overall impact and potential risk of early puberty remain uncertain. In this study, we conducted a comprehensive review of existing epidemiological studies to gain insights into the long-term adverse health effects associated with early puberty. Our objective was to provide a consolidated summary of these outcomes at a population level by considering studies that encompass various indicators of puberty. In all, early puberty has been identified as a potential risk factor for various metabolic diseases, such as obesity, diabetes, cardiovascular diseases (CVD). Children who experience early puberty are more likely to have a higher body mass index (BMI) during adulthood, increasing their risk of obesity. Early puberty also has been found to be an independent risk factor for diabetes mellitus, including gestational diabetes mellitus (GDM) and type 2 diabetes mellitus (T2DM), as earlier onset of menarche in girls and voice breaking in boys is associated with a higher prevalence of T2DM. Furthermore, evidence suggests that early puberty may contribute to an elevated risk of CVD, including conditions like coronary heart disease (CHD), stroke, angina, and hypertension. In addition, adolescents who experience early puberty, particularly girls, are more likely to suffer from mental problems, such as behavioral dysfunction and depression. Notably, early puberty has a more significant impact on girls than boys. Further research should consider the underlying mechanisms and potential preventive measures.
C1 [Sun, Yukun; Liu, Haiyan; Mu, Chunguang; Hao, Changfu; Xin, Yongjuan] Zhengzhou Univ, Sch Publ Hlth, Dept Child & Adolescent Hlth, Zhengzhou, Henan, Peoples R China.
   [Liu, Haiyan] Tongren Ctr Dis Control & Prevent, Dept Emergency Response, Tongren, Guizhou, Peoples R China.
   [Liu, Peipei] Zhengzhou Univ, Affiliated Hosp 1, Dept Neurol, Clin Syst Biol Labs, Zhengzhou, Henan, Peoples R China.
C3 Zhengzhou University; Zhengzhou University
RP Xin, YJ (corresponding author), Zhengzhou Univ, Sch Publ Hlth, Dept Child & Adolescent Hlth, Zhengzhou, Henan, Peoples R China.
EM yjxin@zzu.edu.cn
RI Liu, Peipei/LZF-3767-2025; Haiyan, Liu/AAA-3930-2022
OI Xin, Yongjuan/0000-0003-1716-5728; Hao, Changfu/0000-0001-6819-2529
FU National Natural Science Foundation of China [82173491, 32171171];
   Natural Science Foundation of Henan Province, China [212300410274]
FX The authors declare financial support was received for the research,
   authorship, and/or publication of this article. This work was supported
   by research grants from the National Natural Science Foundation of China
   (82173491, 32171171) and the Natural Science Foundation of Henan
   Province, China(212300410274).
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NR 93
TC 4
Z9 4
U1 4
U2 9
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-2360
J9 FRONT PEDIATR
JI Front. Pediatr.
PD SEP 12
PY 2024
VL 12
AR 1326864
DI 10.3389/fped.2024.1326864
PG 9
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA H1H3Y
UT WOS:001321017200001
PM 39328587
OA gold
DA 2025-06-11
ER

PT J
AU Tang, X
   Liu, QG
AF Tang, Xiao
   Liu, Qigui
TI Prediction of the development of metabolic syndrome by the Markov model
   based on a longitudinal study in Dalian City
SO BMC PUBLIC HEALTH
LA English
DT Article
DE Metabolic syndrome; Prediction; Intervention; Obesity
ID LIFE-STYLE INTERVENTION; QUALITY-OF-LIFE; CARDIOVASCULAR RISK; ADULTS;
   POPULATION; PREVALENCE; OBESITY; DEPRESSION; HEALTH; WOMEN
AB Background: Metabolic syndrome (MetS) increases the incidence of cardiovascular disease and diabetes mellitus. It is essential to study the natural progression of MetS in the interest of prevention. Information on the dynamic changes in MetS in developing countries is limited. This study aimed to simulate the progression of each component of MetS and explore the potential role of these components in early prevention and intervention.
   Methods: This study involved 5881 individuals, aged 20 to 60 at study entry, who underwent at least two consecutive years of health check-ups in the seven-year study period at our institution's health check-up center. Participants were divided into four groups by age (a 20- to- 40-year-old group and a 40- to 60-year-old group) and gender. A Markov model containing 7 stages (no components, isolated hypertension, isolated obesity, isolated hyperglycemia, isolated dyslipidemia, a 2-component state, and the MetS state) was constructed for each group.
   Results: In women and young men (20- to 40-year-old men), dyslipidemia and obesity were the two most probable states for individuals who were transitioning from no components to one of the other six states. Among those who had no components and were 30 years old at study entry, MetS was estimated to develop within 10 years in 11.42% of men and 3.04% of women. Among those who had no components and were 50 years old at study entry, MetS was estimated to develop within 10 years in 25.04% of men and 7.09% of women. The estimated prevalence of MetS over the next 10 years was higher in individuals starting with the obesity component than in individuals starting with any other isolated component. In a comparison of interventions targeting single components, simulations showed that the obesity intervention produced the largest relative reduction in the prevalence of MetS.
   Conclusion: Markov models are suitable for describing and predicting the dynamic development of MetS. The occurrence of MetS most frequently began with dyslipidemia or obesity. Obesity played a predominant role in the development of MetS. Early obesity intervention was extremely important for MetS prevention.
C1 [Tang, Xiao; Liu, Qigui] Dalian Med Univ, Sch Publ Hlth, 9 West Sect Lvshun South Rd, Dalian 116044, Liaoning, Peoples R China.
C3 Dalian Medical University
RP Liu, QG (corresponding author), Dalian Med Univ, Sch Publ Hlth, 9 West Sect Lvshun South Rd, Dalian 116044, Liaoning, Peoples R China.
EM liuqiguidl@163.com
RI Tang, Xiao/AAJ-6904-2020
OI Tang, Xiao/0000-0003-1941-9437
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NR 39
TC 13
Z9 13
U1 0
U2 10
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2458
J9 BMC PUBLIC HEALTH
JI BMC Public Health
PD JUN 7
PY 2018
VL 18
AR 707
DI 10.1186/s12889-018-5599-y
PG 9
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA GI6DE
UT WOS:000434458900006
PM 29879952
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Palermi, S
   Sacco, AM
   Belviso, I
   Romano, V
   Montesano, P
   Corrado, B
   Sirico, F
AF Palermi, Stefano
   Sacco, Anna Maria
   Belviso, Immacolata
   Romano, Veronica
   Montesano, Pietro
   Corrado, Bruno
   Sirico, Felice
TI Guidelines for Physical Activity-A Cross-Sectional Study to Assess Their
   Application in the General Population. Have We Achieved Our Goal?
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Article
DE guidelines; physical activity; sport; health; prevention
ID OVERTRAINING SYNDROME; WARM-UP; PREVENTION; EXERCISE; SPORT;
   PARTICIPATION; STRATEGIES; INACTIVITY; DISEASES; STRESS
AB National and international healthcare organizations propose guidelines for physical activity worldwide, defining its characteristics. These guidelines' practical applications are difficult to estimate, since they are not fully followed. The aim of the present cross-sectional observational study was to assess awareness about guidelines for physical activity and to evaluate their practical applications in a sample of the Italian population. In total, 310 participants completed an online survey (mean age 29.10 +/- 4.44), assessing the habits, beliefs and health effects of physical activity. In total, 39.35% of respondents were inactive. In total, 6.91% of active respondents did not perform a warm-up phase at the beginning of each training session and 77.14% did not check their own heart rate during the training session. Approximately half of respondents reported erroneous beliefs about the type, frequency and volume of physical activity, compared to data proposed by the guidelines. The preventive effect of physical activity was clearly perceived for cardiovascular diseases, diabetes, metabolic syndrome and depression. Several subjects misinterpreted the preventive role of physical activity in colon and breast cancers, and in femur and vertebral fractures. Habits and beliefs about physical activity in the general population are far from the guidelines and recommendations. Therefore, it is necessary to strengthen the conscious practice of physical activity further.
C1 [Palermi, Stefano; Sacco, Anna Maria; Belviso, Immacolata; Romano, Veronica; Corrado, Bruno; Sirico, Felice] Univ Naples Federico II, Dept Publ Hlth, I-80131 Naples, Italy.
   [Montesano, Pietro] Univ Naples Parthenope, Dept Motor Sci & Wellness, I-80133 Naples, Italy.
C3 University of Naples Federico II; Parthenope University Naples
RP Sirico, F (corresponding author), Univ Naples Federico II, Dept Publ Hlth, I-80131 Naples, Italy.
EM stefano.palermi@unina.it; annamaria.sacco@unina.it;
   immacolata.belviso@unina.it; veronica.romano@unina.it;
   pieromontesano@libero.it; bruno.corrado@unina.it;
   felice.sirico2@unina.it
RI Romano, Veronica/AAM-4208-2020; Belviso, Immacolata/AAI-4676-2021;
   Sirico, Felice/O-9705-2019; Palermi, Stefano/ABC-1237-2021; Corrado,
   Bruno/U-9495-2017
OI Palermi, Stefano/0000-0003-1558-4857; Sirico, Felice/0000-0001-6801-3308
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NR 61
TC 26
Z9 31
U1 0
U2 4
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD JUN
PY 2020
VL 17
IS 11
AR 3980
DI 10.3390/ijerph17113980
PG 14
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA MB5FY
UT WOS:000542629600233
PM 32512767
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Swarnalatha, NB
   Roy, N
   Gouda, MM
   Moger, R
   Abraham, A
AF Swarnalatha, Nagaraj Banavara
   Roy, Neena
   Gouda, Mahesh Manjunath
   Moger, Rajeish
   Abraham, Asha
TI High-fat, simple-carbohydrate diet intake induces
   hypothalamic-pituitary-thyroid axis dysregulation in C57BL/6J male mice
SO APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
LA English
DT Article
DE hypothalamus-pituitary-thyroid (HPT) axis; TSH; T-3; TRH; TRH receptors;
   thyroid gland; ObR; p-STAT3; metabolic syndrome; HFSC feed; C57BL/6J
   mice
ID THYROTROPIN-RELEASING-HORMONE; RECEPTOR 1-DEFICIENT MICE; LEPTIN
   RECEPTOR; METABOLIC SYNDROME; SUBCLINICAL HYPOTHYROIDISM;
   CARDIOVASCULAR-DISEASE; INCREASED DEPRESSION; STIMULATING HORMONE;
   ENERGY HOMEOSTASIS; INSULIN-RESISTANCE
AB Given the association between subclinical hypothyroidism and metabolic syndrome, we wanted to explore if high-fat, simple-carbohydrate (HFSC) diet affects hypothalamus-pituitary-thyroid axis. One-month-old male C57BL/6J mice were fed with control (C) and HFSC (T) feed (n = 18 each), respectively, for 5 months. There was a significant increase in triiodothyronine in the T group (13.5%) compared with the age-matched C group by the fifth month. Thyroid-stimulating hormone was significantly higher (1 month: 1.9-fold; 3 months: 2.66-fold; 5 months: 3.5-fold) from the first to fifth months in the T group compared with age-matched C group. Thyrotropin-releasing hormone (TRH) gene expression showed significant decrease (1 month: 83.2%; 5 months: 40.7%) in the T group compared with the age-matched C group. TRHR1 showed significant decrease in the T group compared with the age-matched C group throughout the study (1 month: 82.8%; 3 months: 45.7%; 5 months: 75.2%). However, TRHR2 showed dynamic change during the study. Initially there was significant (1 month: 0.104-fold) downregulation, followed by significant upregulation (3 months: 3.6-fold) and downregulation (0.73-fold) by the fifth month in the T group compared with the age-matched C group. There was marked depletion of functional follicular cells and colloid substance in the thyroid glands of the T group by the fifth month compared with the C group. Leptin receptors ObRa (1 month: 48.25%; 5 months: 88%) and ObRb (1 month: 46.9%; 5months: 63.3%) were significantly downregulated in the T group compared with the age-matched C group in the first and fifth months of feeding the respective diets. The expression of p-STAT3, a transcription factor known to have a role in energy balance, intermediate metabolism, and leptin signalling was seen to decrease significantly (6.25-fold) in the hypothalamus of the T group compared with the age-matched C group. In conclusion, HFSC feed disrupts the hypothalamus-pituitary-thyroid axis in male C57BL/6J mice.
C1 [Swarnalatha, Nagaraj Banavara; Roy, Neena; Abraham, Asha] St Aloysius Coll Autonomous, Dept Postgrad Studies & Res Biotechnol, Father George Albuquerque Pai Cell & Mol Biol Lab, Mangaluru 575003, India.
   [Swarnalatha, Nagaraj Banavara] St Aloysius Coll Autonomous, PG Dept Biochem, Mangaluru 575003, India.
   [Gouda, Mahesh Manjunath] Yenepoya Univ, Yenepoya Res Ctr, Mangaluru 575018, India.
   [Moger, Rajeish] Coll Fisheries, Dept Fisheries Microbiol, Mangaluru 575002, India.
C3 Yenepoya (Deemed to be University)
RP Abraham, A (corresponding author), St Aloysius Coll Autonomous, Dept Postgrad Studies & Res Biotechnol, Father George Albuquerque Pai Cell & Mol Biol Lab, Mangaluru 575003, India.
EM abraham.asha@gmail.com
RI Roy, Neena/AFE-6889-2022; Abraham, Asha/ABD-8580-2020
OI Latha, Swarna/0000-0002-1502-4473; Roy, Neena/0000-0001-7702-3196;
   Abraham, Asha/0000-0002-0201-5551
FU University Grants Commission, South western Office Bangalore
   [MRP(S)113-12/13-KAMA002/UGC-SWRO]; University Grants Commission, New
   Delhi [39-251/2010(SR)]; Board of Research in Nuclear Sciences (BRNS),
   Mumbai, India [2013/35/7/BRNS/21]
FX Swarnalatha B. Nagaraj thanks University Grants Commission, South
   western Office Bangalore for providing minor research project
   (MRP(S)113-12/13-KAMA002/UGC-SWRO) and Dr. Asha Abraham acknowledges the
   grants received from University Grants Commission, New Delhi
   (F.No.39-251/2010(SR) dated 1-2-2011 and Board of Research in Nuclear
   Sciences (BRNS), Mumbai, India (Sanction No 2013/35/7/BRNS/21 dated
   1-4-2013). Authors also thank Dr. Girisha (Assistant Professor),
   Department of Fisheries Microbiology, and Dr. Ajay S. Khandagale
   (Assistant Professor), Department of Biochemistry, College of Fisheries,
   for their timely help. Dr. Ashwini, Yenepoya University, Mangaluru,
   India, is also acknowledged for her help. Authors thank The Principal
   and Management of St Aloysius College for providing the facilities.
   Department of Metallurgical & Material Engineering, National Institute
   of Technology Karnataka (NITK), Surathkal, India, is acknowledged for
   making available the SEM for the present study.
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NR 71
TC 4
Z9 4
U1 0
U2 10
PU CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS
PI OTTAWA
PA 65 AURIGA DR, SUITE 203, OTTAWA, ON K2E 7W6, CANADA
SN 1715-5312
EI 1715-5320
J9 APPL PHYSIOL NUTR ME
JI Appl. Physiol. Nutr. Metab.
PD APR
PY 2018
VL 43
IS 4
BP 371
EP 380
DI 10.1139/apnm-2017-0410
PG 10
WC Nutrition & Dietetics; Physiology; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics; Physiology; Sport Sciences
GA GA6FG
UT WOS:000428427800008
PM 29099999
DA 2025-06-11
ER

PT J
AU Chaves, TR
   Lima, RPA
   Ribeiro, MR
   Boico, VF
   Ferreira, FELD
   Gonçalves, MDR
   De Almeida, ATC
   De Moraes, RM
   Silva, AS
   Cardoso, GA
   De Lima, RT
   Costa, MJD
   Luna, RCP
AF Chaves, Thamires Ribeiro
   Ataide Lima, Raquel Patricia
   Ribeiro, Marina Ramalho
   Boico, Vitor Ferreira
   Leite De Lima Ferreira, Flavia Emilia
   Rodrigues Goncalves, Maria da Conceicao
   Cavalcanti De Almeida, Alessio Tony
   De Moraes, Ronei Marcos
   Silva, Alexandre Sergio
   Cardoso, Gleba Alexa
   De Lima, Roberto Teixeira
   de Carvalho Costa, Maria Jose
   Pordeus Luna, Rafaella Cristhine
TI Association between values of anthropometric indicators, Total
   Antioxidant Capacity and Malondialdehyde in adults: a population-based
   study
SO NUTRICION CLINICA Y DIETETICA HOSPITALARIA
LA English
DT Article
DE Anthropometry; Obesity; Antioxidant; Malondialdehyde; Oxidative Stress
ID TO-HEIGHT RATIO; CARDIOMETABOLIC RISK; WAIST CIRCUMFERENCE; OXIDATIVE
   STRESS; OBESITY; BIOMARKERS
AB Background: Research regarding the correlation between obesity and oxidative stress is important due to the health complications they entail and elucidating this association through the waist-to-height ratio is of great interest because it is an important anthropometric indicator of cardiovascular and metabolic diseases' risk associated with obesity. The aim of this study was to gain a better understanding of the association between waist-to-height ratio and total antioxidant capacity and malondialdehyde values in adults.
   Methods: A cross-sectional population-based study was conducted in 265 individuals from a municipality in northeastern Brazil. Epidemiological data were collected, and anthropometric and biochemical evaluations were performed. To achieve the objectives proposed by the study, linear regression was performed.
   Results: In the total sample, more than half of the participants were overweight or obese. The mean value of 54 cm (SD +/- 10) waist-to-height ratio, with the majority of adults (65.28%) presenting with slight elevation waist-to-height ratio. A correlation was found between waist-to-height ratio and BMI with the values of total antioxidant capacity (t= -2.96; p=0.003) and malondialdehyde (t=2.87, p=0.004), as well as LDL (t=3.19, p=0.002), triglycerides (t=3.17; p=0.002).
   Conclusion: Abdominal obesity, reflected by a slight elevation in the waist-to-height ratio, corroborated by BMI was indicated as an aggravating factor in oxidative stress increase because it was positively related with malondialdehyde values and negatively with total antioxidant capacity values in this adult population.
C1 [Chaves, Thamires Ribeiro; Ataide Lima, Raquel Patricia; Ribeiro, Marina Ramalho] Univ Fed Paraiba, ICSNH Interdisciplinary Ctr Studies Nutr & Hlth, Hlth Sci Ctr, Joao Pessoa, Paraiba, Brazil.
   [Boico, Vitor Ferreira] Univ Estadual Campinas, Dept Nutr, Campinas, Brazil.
   [Leite De Lima Ferreira, Flavia Emilia; Rodrigues Goncalves, Maria da Conceicao; De Lima, Roberto Teixeira; de Carvalho Costa, Maria Jose] Univ Fed Paraiba, Program Grad Nutr Sci, Dept Nutr, Joao Pessoa, Paraiba, Brazil.
   [Cavalcanti De Almeida, Alessio Tony] Univ Fed Paraiba, Dept Econ, Joao Pessoa, Paraiba, Brazil.
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   [Silva, Alexandre Sergio; Cardoso, Gleba Alexa] Univ Fed Paraiba, Phys Educ UPE UFPB, Joao Pessoa, Paraiba, Brazil.
   ICSNH Fed Univ Paraiba, Joao Pessoa, Paraiba, Brazil.
C3 Universidade Federal da Paraiba; Universidade Estadual de Campinas;
   Universidade Federal da Paraiba; Universidade Federal da Paraiba;
   Universidade Federal da Paraiba; Universidade Federal da Paraiba
RP Chaves, TR (corresponding author), Univ Fed Paraiba, ICSNH Interdisciplinary Ctr Studies Nutr & Hlth, Hlth Sci Ctr, Joao Pessoa, Paraiba, Brazil.
EM thamiresribeiro.nutri@gmail.com
RI de Moraes, Ronei/AAE-8156-2019; Silva, Alexandre/N-8883-2014; Almeida,
   Aléssio/T-3557-2017; Luna, Rafaella/L-1733-2015
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NR 39
TC 2
Z9 3
U1 1
U2 2
PU SOC ESPANOLA DIETETICA & CIENCIAS ALIMENTACION-SEDCA
PI MADRID
PA APARTADO 60055, MADRID, 28080, SPAIN
SN 0211-6057
EI 1989-208X
J9 NUTR CLIN DIET HOSP
JI Nutr. Clin. Diet. Hosp.
PY 2021
VL 41
IS 3
BP 47
EP 57
DI 10.12873/413thamires
PG 11
WC Nutrition & Dietetics
WE Emerging Sources Citation Index (ESCI)
SC Nutrition & Dietetics
GA YW6LO
UT WOS:000753524800006
DA 2025-06-11
ER

PT J
AU De Sousa, RAL
   Torres, YS
   Figueiredo, CP
   Passos, GF
   Clarke, JR
AF De Sousa, Ricardo A. L.
   Torres, Yasmin S.
   Figueiredo, Claudia P.
   Passos, Giselle F.
   Clarke, Julia R.
TI Consequences of gestational diabetes to the brain and behavior of the
   offspring
SO ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS
LA English
DT Article
DE insulin resistance; depression; memory; programing; inflammation;
   hippocampus; learning
ID HIGH-FAT DIET; ENDOPLASMIC-RETICULUM STRESS; IMPAIRED
   GLUCOSE-HOMEOSTASIS; INSULIN-RECEPTOR SUBSTRATE; TERM COGNITIVE
   IMPAIRMENT; BETA-AMYLOID OLIGOMERS; ALZHEIMERS-DISEASE; MEMORY
   PERFORMANCE; METABOLIC SYNDROME; CELL ADAPTATION
AB Gestational diabetes mellitus (GD) is a form of insulin resistance triggered during the second/third trimesters of pregnancy in previously normoglycemic women. It is currently estimated that 10% of all pregnancies in the United States show this condition. For many years, the transient nature of GD has led researchers and physicians to assume that long-term consequences were absent. However, GD diagnosis leads to a six-fold increase in the risk of developing type 2 diabetes (T2D) in women and incidence of obesity and T2D is also higher among their infants. Recent and concerning evidences point to detrimental effects of GD on the behavior and cognition of the offspring, which often persist until adolescence or adulthood. Considering that the perinatal period is critical for determination of adult behavior, it is expected that the intra-uterine exposure to hyperglycemia, hyperinsulinemia and pro-inflammatory mediators, hallmark features of GD, might affect brain development. Here, we review early clinical and experimental evidence linking GD to consequences on the behavior of the offspring, focusing on memory and mood disorders. We also discuss initial evidence suggesting that downregulation of insulin signaling cascades are seen in the brains of GD offspring and could contribute to the consequences on their behavior.
C1 [De Sousa, Ricardo A. L.; Torres, Yasmin S.; Figueiredo, Claudia P.; Passos, Giselle F.; Clarke, Julia R.] Univ Fed Rio de Janeiro, Sch Pharm, Carlos Chagas Filho St 373,Bldg A,Room 024, BR-21941902 Rio De Janeiro, RJ, Brazil.
C3 Universidade Federal do Rio de Janeiro
RP Clarke, JR (corresponding author), Univ Fed Rio de Janeiro, Sch Pharm, Carlos Chagas Filho St 373,Bldg A,Room 024, BR-21941902 Rio De Janeiro, RJ, Brazil.
EM juclarke@gmail.com
RI Figueiredo, Claudia/F-8424-2012; Clarke, Julia/AAF-9434-2019; De Sousa,
   Ricardo Augusto Leoni/C-8540-2015
OI Fazzioni Passos, Giselle/0009-0000-3368-2878; Figueiredo,
   Claudia/0000-0001-9467-9891
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NR 102
TC 22
Z9 24
U1 0
U2 12
PU ACAD BRASILEIRA DE CIENCIAS
PI RIO JANEIRO
PA RUA ANFILOFIO DE CARVALHO, 29, 3 ANDAR, 20030-060 RIO JANEIRO, BRAZIL
SN 0001-3765
EI 1678-2690
J9 AN ACAD BRAS CIENC
JI An. Acad. Bras. Cienc.
PD AUG
PY 2018
VL 90
IS 2
SU 1
BP 2279
EP 2291
DI 10.1590/0001-3765201720170264
PG 13
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Science & Technology - Other Topics
GA GQ9KZ
UT WOS:000442096300029
PM 28813108
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU László, A
   Lénárt, L
   Illésy, L
   Fekete, A
   Nemcsik, J
AF Laszlo, Andrea
   Lenart, Lilla
   Illesy, Lilla
   Fekete, Andrea
   Nemcsik, Janos
TI The role of neurotrophins in psychopathology and cardiovascular
   diseases: psychosomatic connections
SO JOURNAL OF NEURAL TRANSMISSION
LA English
DT Review
DE Neurotrophic factors; Mood disorders; Cardiovascular diseases;
   Psychosomatic connections
ID NERVE GROWTH-FACTOR; FACTOR SERUM-LEVELS; MAJOR DEPRESSION; FACTOR BDNF;
   MESSENGER-RNA; BLOOD-BRAIN; CORONARY ATHEROSCLEROSIS; ARTERIAL
   BARORECEPTOR; METABOLIC SYNDROME; PROTEIN-SYNTHESIS
AB Cardiovascular (CV) diseases and mood disorders are common public health problems worldwide. Their connections are widely studied, and the role of neurotrophins (NTs) is already supposed in both conditions. However, data in the literature of clinical aspects are sometimes controversial and no reviews are available describing possible associations between CV risk and mood disorders based on NTs. The mostly studied NT is brain-derived neurotrophic factor (BDNF). Decreased level of BDNF is observed in depression and its connection to hypertension has also been demonstrated with affecting the arterial baroreceptors, renin-angiotensin system and endothelial nitric oxide synthase. BDNF was also found to be the predictor of CV outcome in different patient populations. Other types of human NT-s, such as nerve growth factor, neurotrophin 3 and neurotrophin 4 also seem to have both psychopathological and CV connections. Our aim was to overview the present knowledge in this area, demonstrating a new aspect of the associations between mood disorders and CV diseases through the mediation of NTs. These findings might enlighten new psychosomatic connections and suggest new therapeutic targets that are beneficial both in respect of mood disorders and CV pathology.
C1 [Laszlo, Andrea; Nemcsik, Janos] Semmelweis Univ, Dept Family Med, Budapest, Hungary.
   [Laszlo, Andrea; Fekete, Andrea] First German Hosp Tradit Chinese Med, Bad Kotzting, Germany.
   [Lenart, Lilla; Illesy, Lilla] MTA SE Lendulet Diabet Res Grp, Budapest, Hungary.
   [Lenart, Lilla; Fekete, Andrea] MTA SE Pediat & Nephrol Res Grp, Budapest, Hungary.
   [Nemcsik, Janos] Hlth Serv Zuglo ZESZ, Budapest, Hungary.
C3 Semmelweis University; Semmelweis University
RP László, A (corresponding author), Semmelweis Univ, Dept Family Med, Budapest, Hungary.; László, A (corresponding author), First German Hosp Tradit Chinese Med, Bad Kotzting, Germany.
EM laszloandrea@gmail.com
FU EEMOFAKT-2017; 'Momentum' Program of the Hungarian Academy of Sciences
   [LP008/2017];  [OTKA-K112629-FK124491];  [NN-11460];  [VKE-2017-00006]
FX Andrea Fekete and Lilla Lenart were supported by the following research
   grants: OTKA-K112629-FK124491, NN-11460, VKE-2017-00006, EEMOFAKT-2017
   and the 'Momentum' Program of the Hungarian Academy of Sciences
   LP008/2017. However, these grants had no influence for the content of
   this review paper.
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NR 171
TC 15
Z9 16
U1 1
U2 9
PU SPRINGER WIEN
PI WIEN
PA SACHSENPLATZ 4-6, PO BOX 89, A-1201 WIEN, AUSTRIA
SN 0300-9564
EI 1435-1463
J9 J NEURAL TRANSM
JI J. Neural Transm.
PD MAR
PY 2019
VL 126
IS 3
BP 265
EP 278
DI 10.1007/s00702-019-01973-6
PG 14
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology
GA HO1FL
UT WOS:000460650800004
PM 30767081
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Löffler, AI
   Bourque, JM
AF Loeffler, Adrian I.
   Bourque, Jamieson M.
TI Coronary Microvascular Dysfunction, Microvascular Angina, and Management
SO CURRENT CARDIOLOGY REPORTS
LA English
DT Review
DE Coronary microvascular dysfunction; Microvascular angina; Therapeutics;
   Prognosis
ID ABSOLUTE MYOCARDIAL-PERFUSION; FLOW RESERVE; ARTERY-DISEASE; CHEST-PAIN;
   DOPPLER-ECHOCARDIOGRAPHY; NATIONAL HEART; SYNDROME-X; WOMEN; RISK; PET
AB Recent analyses have found that coronary microvascular dysfunction (CMD) portends a poor prognosis in patients with and without obstructive epicardial coronary artery disease (CAD). Chest pain in the absence of epicardial CAD is a common entity. Angina caused by CMD, microvascular angina (MVA), is often indistinguishable from that caused by obstructive epicardial CAD. The recent emergence of noninvasive techniques that can identify CMD, such as stress positron-emission tomography (PET) and cardiovascular magnetic resonance (CMR) myocardial perfusion imaging, allow improved identification of MVA. Using these tools, higher risk patients with MVA can be differentiated from those at lower risk in the heterogeneous population historically labeled as cardiac syndrome X. Likewise, MVA can be diagnosed in those with obstructive epicardial CAD who have persistent angina despite successful revascularization. There is little evidence to support current treatment strategies for MVA and current literature has not clearly defined CMD or whether therapy improves prognosis.
C1 [Loeffler, Adrian I.] Univ Virginia Hlth Syst, Div Cardiovasc Med, Charlottesville, VA 22908 USA.
   [Bourque, Jamieson M.] Univ Virginia Hlth Syst, Div Cardiovasc Med & Radiol, Charlottesville, VA 22908 USA.
C3 University of Virginia; University of Virginia (UVA) Health System;
   University of Virginia; University of Virginia (UVA) Health System
RP Bourque, JM (corresponding author), Univ Virginia Hlth Syst, Div Cardiovasc Med & Radiol, 1215 Lee St,Box 800158, Charlottesville, VA 22908 USA.
EM jbourque@virginia.edu; al2ys@hscmail.mcc.virginia.edu
FU Dr. Bourque's NIH grant [1K23HL119620-01]
FX This research is supported by Dr. Bourque's NIH grant 1K23HL119620-01.
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NR 43
TC 56
Z9 62
U1 4
U2 29
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1523-3782
EI 1534-3170
J9 CURR CARDIOL REP
JI Curr. Cardiol. Rep.
PD JAN
PY 2016
VL 18
IS 1
AR 1
DI 10.1007/s11886-015-0682-9
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA DA9QU
UT WOS:000368145400001
PM 26694723
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Jin, H
   Shih, PAB
   Golshan, S
   Mudaliar, S
   Henry, R
   Glorioso, DK
   Arndt, S
   Kraemer, HC
   Jeste, DV
AF Jin, Hua
   Shih, Pei-an Betty
   Golshan, Shahrokh
   Mudaliar, Sunder
   Henry, Robert
   Glorioso, Danielle K.
   Arndt, Stephan
   Kraemer, Helena C.
   Jeste, Dilip V.
TI Comparison of Longer-Term Safety and Effectiveness of 4 Atypical
   Antipsychotics in Patients Over Age 40: A Trial Using
   Equipoise-Stratified Randomization
SO JOURNAL OF CLINICAL PSYCHIATRY
LA English
DT Article
ID POSTTRAUMATIC-STRESS-DISORDER; METABOLIC SYNDROME; CONSENSUS STATEMENT;
   CLINICAL-TRIALS; PREVALENCE; DRUGS; HEALTH; SCHIZOPHRENIA; CATIE;
   DEFINITIONS
AB Objective: To compare longer-term safety and effectiveness of the 4 most commonly used atypical antipsychotics (aripiprazole, olanzapine, quetiapine, and risperidone) in 332 patients, aged >40 years, having psychosis associated with schizophrenia, mood disorders, posttraumatic stress disorder, or dementia, diagnosed using DSM-IV-TR criteria.
   Method: We used equipoise-stratified randomization (a hybrid of complete randomization and clinician's choice methods) that allowed patients or their treating psychiatrists to exclude 1 or 2 of the study atypical antipsychotics due to past experience or anticipated risk. Patients were followed for up to 2 years, with assessments at baseline, 6 weeks, 12 weeks, and every 12 weeks thereafter. Medications were administered employing open-label design and flexible dosages, but with blind raters. The study was conducted from October 2005 to October 2010.
   Outcome Measures: Primary metabolic markers (body mass index, blood pressure, fasting blood glucose, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and triglycerides), percentage of patients who stay on the randomly assigned atypical antipsychotic for at least 6 months, psychopathology, percentage of patients who develop metabolic syndrome, and percentage of patients who develop serious and nonserious adverse events.
   Results: Because of a high incidence of serious adverse events, quetiapine was discontinued midway through the trial.There were significant differences among patients willing to be randomized to different atypical antipsychotics (P<.01), suggesting that treating clinicians tended to exclude olanzapine and prefer aripiprazole as one of the possible choices in patients with metabolic problems. Yet, the atypical antipsychotic groups did not differ in longitudinal changes in metabolic parameters or on most other outcome measures. Overall results suggested a high discontinuation rate (median duration 26 weeks prior to discontinuation), lack of significant improvement in psychopathology, and high cumulative incidence of metabolic syndrome (36.5% in 1 year) and of serious (23.7%) and nonserious (50.8%) adverse events for all atypical antipsychotics in the study.
   Conclusions: Employing a study design that closely mimicked clinical practice, we found a lack of effectiveness and a high incidence of side effects with 4 commonly prescribed atypical antipsychotics across diagnostic groups in patients over age 40, with relatively few differences among the drugs. Caution in the use of these drugs is warranted in middle-aged and older patients. Trial Registration: ClinicalTrials.gov identifier: NCT00245206 J Clin Psychiatry 2013;74(1):10-18 (C) Copyright 2012 Physicians Postgraduate Press, Inc.
C1 [Jin, Hua; Shih, Pei-an Betty; Golshan, Shahrokh; Glorioso, Danielle K.; Jeste, Dilip V.] Univ Calif San Diego, Dept Psychiat, San Diego, CA 92103 USA.
   [Jeste, Dilip V.] Univ Calif San Diego, Dept Neurosci, San Diego, CA 92103 USA.
   [Mudaliar, Sunder; Henry, Robert] Univ Calif San Diego, Dept Med, San Diego, CA 92103 USA.
   [Jin, Hua; Mudaliar, Sunder; Henry, Robert] VA San Diego Healthcare Syst, Div Med, San Diego, CA USA.
   [Arndt, Stephan] Univ Iowa, Dept Psychiat, Iowa City, IA 52242 USA.
   [Kraemer, Helena C.] Stanford Univ, Dept Psychiat & Behav Sci, Stanford, CA 94305 USA.
   [Kraemer, Helena C.] Univ Pittsburgh, Dept Psychiat, Pittsburgh, PA 15260 USA.
C3 University of California System; University of California San Diego;
   University of California System; University of California San Diego;
   University of California System; University of California San Diego; US
   Department of Veterans Affairs; Veterans Health Administration (VHA); VA
   San Diego Healthcare System; University of Iowa; Stanford University;
   Pennsylvania Commonwealth System of Higher Education (PCSHE); University
   of Pittsburgh
RP Jeste, DV (corresponding author), Univ Calif San Diego, Clin & Translat Res Inst, 9500 Gilman Dr 0664, La Jolla, CA 92093 USA.
EM djeste@ucsd.edu
RI Arndt, Stephan/A-6976-2013; Mudaliar, Sunder/N-5813-2019; jin,
   hua/AAX-1569-2020; Shih, Pei-an (Betty)/M-9504-2016
OI Shih, Pei-an (Betty)/0000-0001-5318-6476; Arndt,
   Stephan/0000-0003-0783-8204
FU AstraZeneca; Bristol Myers Squibb; National Institutes of Health
   [MH071536, P30 MH080002-01, 1K01DK087813-01, NCRS UL1RR031980];
   department of Veterans Affairs; National Center for Research Resources
   [M01RR 000827]; United States Public Health Service
FX Dr Mudaliar is a consultant to, received grant/research support and
   honoraria from, and has participated in the speakers bureaus for
   AstraZeneca and Bristol Myers Squibb, which manufacture the drugs used
   in this study. Drs Jin, Shih, Golshan, Henry, Arndt, Kraemer, and Jeste
   and Ms Glorioso and their spouses have had no relevant financial
   interests or personal affiliations during at least the past 12
   months.This study was supported, in part, by the National Institutes of
   Health grants (MH071536, P30 MH080002-01, 1K01DK087813-01, NCRS
   UL1RR031980) and by the department of Veterans Affairs. It was carried
   out, in part, in the General Clinical Research Center, University of
   California, San Diego with funding provided by the National Center for
   Research Resources, M01RR 000827, United States Public Health Service.
   AstraZeneca, Bristol-Myers Squibb, Eli Lilly, and Janssen Scientific
   Affairs, LLC donated quetiapine, aripiprazole, olanzapine, and
   risperidone, respectively, for this National Institute of Mental
   Health-funded study.
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   Tiihonen J, 2009, LANCET, V374, P620, DOI 10.1016/S0140-6736(09)60742-X
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   Wirshing DA, 2002, J CLIN PSYCHIAT, V63, P856, DOI 10.4088/JCP.v63n1002
NR 49
TC 34
Z9 37
U1 0
U2 22
PU PHYSICIANS POSTGRADUATE PRESS
PI MEMPHIS
PA P O BOX 752870, MEMPHIS, TN 38175-2870 USA
SN 0160-6689
EI 1555-2101
J9 J CLIN PSYCHIAT
JI J. Clin. Psychiatry
PD JAN
PY 2013
VL 74
IS 1
BP 11
EP 19
DI 10.4088/JCP.12m08001
PG 9
WC Psychology, Clinical; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA 083UN
UT WOS:000314490800003
PM 23218100
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Rice, MC
   Katzel, LI
   Waldstein, SR
AF Rice, Melissa C.
   Katzel, Leslie I.
   Waldstein, Shari R.
TI Sex-specific associations of depressive symptoms and cardiovascular risk
   factors in older adults
SO AGING & MENTAL HEALTH
LA English
DT Article
DE depression; cardiovascular risk factors; sex differences; body mass
   index
ID CORONARY-HEART-DISEASE; MYOCARDIAL-INFARCTION; METABOLIC SYNDROME;
   WOMEN; MORTALITY; EXERCISE; EPIDEMIOLOGY; PREVALENCE; DISORDER; HEALTH
AB Objectives: To examine sex-specific associations between depressive symptoms and cardiovascular risk factors in older men and women. Method: One hundred and thirty-one healthy, community-dwelling older adults [mean age = 66(6.59), 63% male] completed the Beck depression inventory, and engaged in assessment of systolic and diastolic blood pressure, body mass index (BMI), waist circumference (WC), fasting total, low- and high-density lipoprotein cholesterol (TC, LDL-C, and HDL-C), triglycerides, glucose, insulin, and maximal aerobic capacity (Vo2max). Sex-stratified hierarchical regression analyses examined the association between depressive symptoms and each risk factor adjusting for age, education, and BMI (select models). Results: Significant associations were found between higher levels of depressive symptoms and greater BMI, WC, insulin, LDL-C, and lower Vo2max in women only (p 0.05). The insulin association was partially mediated by BMI. Conclusion: In healthy older women, but not men, higher levels of depressive symptoms were associated with greater CVD risk factors. Depressive symptoms may confer biobehavioral risk for cardiovascular and metabolic diseases in older women in part via their association with pertinent biomedical risk factors.
C1 [Katzel, Leslie I.; Waldstein, Shari R.] Univ Maryland, Sch Med, Div Gerontol, Baltimore, MD 21201 USA.
   [Rice, Melissa C.] Univ Maryland, Program Gerontol, Baltimore, MD 21201 USA.
   [Katzel, Leslie I.; Waldstein, Shari R.] Baltimore VA Med Ctr, Geriatr Res Educ & Clin Ctr, Baltimore, MD USA.
   [Waldstein, Shari R.] Univ Maryland, Dept Psychol, Baltimore, MD 21201 USA.
C3 University System of Maryland; University of Maryland Baltimore;
   University System of Maryland; University of Maryland Baltimore; US
   Department of Veterans Affairs; Veterans Health Administration (VHA);
   Baltimore VA Medical Center; Geriatric Research Education & Clinical
   Center; University System of Maryland; University of Maryland Baltimore
RP Waldstein, SR (corresponding author), Univ Maryland, Sch Med, Div Gerontol, Baltimore, MD 21201 USA.
EM waldstei@umbc.edu
CR *AM PSYCH ASS, WOM DEPR
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NR 38
TC 18
Z9 21
U1 0
U2 9
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 1360-7863
EI 1364-6915
J9 AGING MENT HEALTH
JI Aging Ment. Health
PY 2010
VL 14
IS 4
BP 405
EP 410
AR PII 921986295
DI 10.1080/13607860903586185
PG 6
WC Geriatrics & Gerontology; Gerontology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Psychiatry
GA 593FT
UT WOS:000277438900004
PM 20455115
DA 2025-06-11
ER

PT J
AU Sarmento, PLDA
   Plavnik, FL
   Scaciota, A
   Lima, JO
   Miranda, RB
   Ajzen, SA
AF da Fonseca Abrantes Sarmento, Priscilla Lopes
   Plavnik, Frida Liane
   Scaciota, Andrea
   Lima, Joab Oliveira
   Miranda, Robson Barbosa
   Ajzen, Sergio Aron
TI Relationship between cardiovascular risk factors and the echogenicity
   and pattern of the carotid intima-media complex in men
SO SAO PAULO MEDICAL JOURNAL
LA English
DT Article
DE Ultrasonography; Carotid intima-media thickness; Atherosclerosis; Risk
   factors; Metabolic syndrome X
ID OXIDATIVE STRESS; THICKNESS; ARTERY; ATHEROSCLEROSIS; PROGRESSION;
   CORONARY; DISEASE; ECHOGENECITY; VASCULATURE; LESIONS
AB CONTEXT AND OBJECTIVE: The thickness of the carotid intima-media complex (C-IMC) is considered to be a marker of early atherosclerosis, but visual and echogenic changes to the C-IMC can also be noted. The objective here was to evaluate the relationship between cardiovascular risk factors and the echo-genicity of the C-IMC and identify those most associated with an "abnormal" C-IMC.
   DESIGN AND SETTING: Cross-sectional study in the ultrasound sector of the Department of Diagnostic Imaging, Universidade Federal de Sao Paulo.
   METHODS: Eighty men were evaluated. Measurements of arterial blood pressure, waist circumference (WC), lipid profile, fasting glucose, uric acid and high-sensitivity C-reactive protein were obtained. The thickness of the C-IMC was measured by means of B-mode ultrasound, and the intima-media gray-scale mean (IM-GSM) and standard deviation (IM-SD) were calculated.
   RESULTS: The following were discriminating variables: fasting glucose (r(2) = 0.036; P = 0.013), uric acid (r(2) = 0.08; P = 0.03), IM-SD (r(2) = 0.43; P < 0.001), IM-GSM (r(2) = 0.35; P < 0.001) and thickness of the C-IMC (r(2) = 0.29; P < 0.001). IM-GSM showed significant correlations with WC (r = -0.22; P = 0.005), fasting glucose (r = -0.24; P = 0.002) and high-density lipoprotein cholesterol (HDL-C) (r = 0.27; P = 0.0007).
   CONCLUSION: IM-GSM showed correlations with WC, fasting glucose and HDL-C. However, uric acid and IM-SD presented the greatest discriminating impact. These results suggest that visual changes in C-IMC may help identify patients with potential cardiovascular risk, independently of the thickness of the C-IMC.
C1 Univ Fed Sao Paulo Unifesp, Dept Diagnost Imaging, Sao Paulo, Brazil.
   Univ Fed Sao Paulo Unifesp, Dept Nephrol, Sao Paulo, Brazil.
C3 Universidade Federal de Sao Paulo (UNIFESP); Universidade Federal de Sao
   Paulo (UNIFESP)
RP Sarmento, PLDA (corresponding author), Av Esperanca 189-602, Joao Pessoa, Paraiba, Brazil.
EM pri.sarmento@globo.com
RI Miranda, Robson/AAI-1291-2019; Plavnik, Frida/I-6068-2012; Puchnick,
   Andrea/E-7826-2014
OI Ajzen, Sergio/0000-0001-6033-6583; Plavnik, Frida/0000-0003-3655-4761;
   de Miranda, Robson Barbosa/0000-0002-9469-639X; Puchnick,
   Andrea/0000-0002-7234-7121
FU Coordination Office for the Improvement of Higher Education Personnel
   (Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior, Capes)
   [33009015.029]
FX Coordination Office for the Improvement of Higher Education Personnel
   (Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior, Capes) for
   scholarship no. 33009015.029
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NR 27
TC 6
Z9 6
U1 0
U2 4
PU ASSOCIACAO PAULISTA MEDICINA
PI SAO PAULO
PA AV BRIG LUIS ANTONIO, 278-7 ANDAR, SAO PAULO, CEP01318-901, BRAZIL
SN 1516-3180
J9 SAO PAULO MED J
JI Sao Paulo Med. J.
PY 2014
VL 132
IS 2
BP 97
EP 104
DI 10.1590/1516-3180.2014.1322490
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA AF3GK
UT WOS:000334599500006
PM 24714990
OA Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Susser, LC
   Parish, S
   Dumas, E
   Nappi, RE
AF Susser, Leah C.
   Parish, Sharon
   Dumas, Emily
   Nappi, Rossella E.
TI Premenstrual dysphoric disorder and sexual function: a narrative review
SO SEXUAL MEDICINE REVIEWS
LA English
DT Review
DE female sexual dysfunction; sexual function; premenstrual dysphoric
   disorder; premenstrual syndrome; premenstrual symptoms; allopregnanolone
ID QUALITY-OF-LIFE; ALLOPREGNANOLONE LEVELS; CARDIOMETABOLIC RISK; WOMEN;
   PREVALENCE; SYMPTOMS; DYSFUNCTION; DEPRESSION; 3-ALPHA,5-ALPHA-THP;
   INFUSIONS
AB Introduction Premenstrual dysphoric disorder (PMDD) and female sexual dysfunction (FSD) are 2 prevalent illnesses in women that cause distress and affect quality of life. There are plausible biological, social, and psychological links between these 2 conditions. Nevertheless, few studies have examined sexual function in women with PMDD. Objectives In this narrative review we summarize the existing literature on sexual function in women with PMDD and with the broader diagnostic classification of premenstrual syndrome and discus the differences between PMDD and more general premenstrual symptomatology, as well as why studying sexual function specifically in PMDD is necessary. We explored reasons why these 2 illnesses may be comorbid and the importance of studying sexual function in this population of women. Methods PubMed literature searches were conducted using relevant keywords. Results Currently, there are few studies examining PMDD and FSD, and the studies available have significant methodologic limitations. Conclusions Investigation of sexual function in women with PMDD is needed. Awareness of the comorbidities for PMDD and FSD can allow implementation of targeted interventions for women suffering from these disorders.
C1 [Susser, Leah C.; Parish, Sharon] Weill Cornell Med Coll, New York, NY USA.
   [Dumas, Emily] New York Presbyterian Hosp Weill Cornell, New York, NY USA.
   [Nappi, Rossella E.] Univ Pavia, Dept Clin, Reprod Med Unit, IRCCS Policlin San Matteo, Pavia, Italy.
   [Susser, Leah C.] NYPH, WBHC, 21 Bloomingdale Rd,OPD, White Plains, NY 10605 USA.
C3 Cornell University; Weill Cornell Medicine; NewYork-Presbyterian
   Hospital; Cornell University; Weill Cornell Medicine; IRCCS Fondazione
   San Matteo; University of Pavia
RP Susser, LC (corresponding author), NYPH, WBHC, 21 Bloomingdale Rd,OPD, White Plains, NY 10605 USA.
EM lcs7001@med.cornell.edu; shp9079@med.cornell.edu; esd9012@nyp.org
RI Nappi, Rossella Elena/AAC-1793-2022
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NR 74
TC 1
Z9 1
U1 3
U2 8
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 2050-0513
EI 2050-0521
J9 SEX MED REV
JI Sex. Med. Rev.
PD JUN 27
PY 2023
VL 11
IS 3
BP 202
EP 211
DI 10.1093/sxmrev/qead007
PG 10
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA L1HN6
UT WOS:001020837100005
PM 36941212
DA 2025-06-11
ER

PT J
AU Chen, Y
   Wu, S
   Liu, HY
   Zhong, ZY
   Bucci, T
   Wang, YM
   Zhao, ML
   Liu, Y
   Yang, ZK
   Gue, Y
   Mcdowell, G
   Huang, B
   Lip, GYH
AF Chen, Yang
   Wu, Shuang
   Liu, Hongyu
   Zhong, Ziyi
   Bucci, Tommaso
   Wang, Yimeng
   Zhao, Manlin
   Liu, Yang
   Yang, Zhengkun
   Gue, Ying
   Mcdowell, Garry
   Huang, Bi
   Lip, Gregory Y. H.
TI Role of oxidative balance score in staging and mortality risk of
   cardiovascular-kidney-metabolic syndrome: Insights from traditional and
   machine learning approaches
SO REDOX BIOLOGY
LA English
DT Article
DE Oxidative balance score; Cardiovascular-kidney-metabolic syndrome;
   Mortality; Oxidative stress; Risk stratification
ID ANTIOXIDANT; DISEASE
AB Objectives: To evaluate the roles of oxidative balance score (OBS) in staging and mortality risk of cardiovascularkidney-metabolic syndrome (CKM). Methods: Data of this study were from the National Health and Nutrition Examination Survey 1999-2018. We performed cross-sectional analyses using multinomial logistic regression to investigate the relationship between OBS and CKM staging. Cox proportional hazards models were used to assess the impact of OBS on mortality outcomes in CKM patients. Additionally, mediation analyses were performed to explore whether OBS mediated the relationships between specific predictors (Life's Simple 7 score [LS7], systemic immune-inflammation index [SII], frailty score) and mortality outcomes. Then, machine learning models were developed to classify CKM stages 3/4 and predict all-cause mortality, with SHapley Additive exPlanations values used to interpret the contribution of OBS components. Results: 21,609 participants were included (20,319 CKM, median [IQR] age: 52.0 [38.0-65.0] years, 54.3% male, median [IQR] follow-up: 9.4 [5.3-14.1] years). Lower OBS quartiles were associated with advanced CKM staging. Moreover, lower OBS quartiles were related to increased mortality risk, compared to Q4 of OBS (allcause mortality: Q1: HR 1.31, 95% CI 1.18-1.46, Q2: HR 1.27, 95% CI 1.14-1.42, Q3: HR 1.18, 95% CI 1.06-1.32; cardiovascular mortality: Q1: HR 1.44, 95% CI 1.16-1.79, Q2: HR 1.39, 95% CI 1.11-1.74, Q3: HR 1.26, 95% CI 1.01-1.57; non-cardiovascular mortality, Q1: HR 1.27, 95% CI 1.12-1.44, Q2: HR 1.23, 95% CI 1.08-1.40, Q3: HR 1.16, 95% CI 1.02-1.31), with optimal risk stratification threshold for OBS was 22. Additionally, OBS mediated (ranging 4.25%-32.85 %) effects of SII, LS7, frailty scores on mortality outcomes. Moreover, light gradient boosting machine achieved the highest performance for predicting advanced CKM staging (area under curve: 0.905) and all-cause mortality (area under curve: 0.875). Cotinine increased risk, while magnesium, vitamin B6, physical activity were protective. Conclusions: This study highlights OBS as a risk stratification tool for CKM, emphasizing oxidative stress's role in CKM staging and mortality risk management.
C1 [Chen, Yang; Liu, Hongyu; Bucci, Tommaso; Zhao, Manlin; Gue, Ying; Lip, Gregory Y. H.] Univ Liverpool, Liverpool John Moores Univ, Liverpool Ctr Cardiovasc Sci, Liverpool, England.
   [Chen, Yang; Liu, Hongyu; Bucci, Tommaso; Zhao, Manlin; Gue, Ying; Lip, Gregory Y. H.] Liverpool Heart & Chest Hosp, Liverpool, England.
   [Chen, Yang] Univ Liverpool, Inst Life Course & Med Sci, Dept Cardiovasc & Metab Med, Liverpool, England.
   [Wu, Shuang; Wang, Yimeng] Chinese Acad Med Sci & Peking Union Med Coll, Fuwai Hosp, Natl Ctr Cardiovasc Dis, Beijing, Peoples R China.
   [Wu, Shuang; Wang, Yimeng] Chinese Acad Med Sci & Peking Union Med Coll, Fuwai Hosp, Natl Ctr Cardiovasc Dis, Natl Clin Res Ctr Cardiovasc Dis, Beijing, Peoples R China.
   [Liu, Hongyu; Liu, Yang] Nanchang Univ, Affiliated Hosp 2, Jiangxi Med Coll, Dept Cardiovasc Med, Nanchang, Jiangxi, Peoples R China.
   [Zhong, Ziyi] Univ Liverpool, Inst Life Course & Med Sci, Dept Musculoskeletal & Ageing Sci, Liverpool, England.
   [Bucci, Tommaso] Sapienza Univ Rome, Dept Clin Internal Anaesthesiol & Cardiovasc Sci, Rome, Italy.
   [Zhao, Manlin] Capital Med Univ, Beijing Anzhen Hosp, Engn Res Ctr Med Devices Cardiovasc Dis Minist Edu, Natl Clin Res Ctr Cardiovasc Dis,Dept Cardiol, Beijing, Peoples R China.
   [Yang, Zhengkun] Tianjin Med Univ, Gen Hosp, Dept Cardiol, Tianjin, Peoples R China.
   Liverpool John Moores Univ, Sch Pharm & Biomol Sci, Liverpool, England.
   [Huang, Bi] Affiliated Hosp 1, Chongqing Med Univ, Dept Cardiol, Chongqing, Peoples R China.
   [Lip, Gregory Y. H.] Aalborg Univ, Danish Ctr Hlth Serv Res, Dept Clin Med, DK-9220 Aalborg, Denmark.
   [Lip, Gregory Y. H.] Med Univ Bialystok, Bialystok, Poland.
C3 Liverpool John Moores University; University of Liverpool; Liverpool
   Heart & Chest Hospital; University of Liverpool; Chinese Academy of
   Medical Sciences - Peking Union Medical College; Fu Wai Hospital - CAMS;
   Peking Union Medical College; Chinese Academy of Medical Sciences -
   Peking Union Medical College; Fu Wai Hospital - CAMS; Peking Union
   Medical College; Nanchang University; University of Liverpool; Sapienza
   University Rome; Capital Medical University; Tianjin Medical University;
   Liverpool John Moores University; Chongqing Medical University; Aalborg
   University; Medical University of Bialystok
RP Chen, Y; Lip, GYH (corresponding author), Univ Liverpool, Liverpool John Moores Univ, Liverpool Ctr Cardiovasc Sci, Liverpool, England.; Chen, Y; Lip, GYH (corresponding author), Liverpool Heart & Chest Hosp, Liverpool, England.; Chen, Y (corresponding author), Univ Liverpool, Inst Life Course & Med Sci, Dept Cardiovasc & Metab Med, Liverpool, England.; Huang, B (corresponding author), Affiliated Hosp 1, Chongqing Med Univ, Dept Cardiol, Chongqing, Peoples R China.; Lip, GYH (corresponding author), Aalborg Univ, Danish Ctr Hlth Serv Res, Dept Clin Med, DK-9220 Aalborg, Denmark.; Lip, GYH (corresponding author), Med Univ Bialystok, Bialystok, Poland.
EM yang.chen2@liverpool.ac.uk; huangbi120@163.com;
   gregory.lip@liverpool.ac.uk
RI Bucci, Tommaso/ABA-4162-2021; Zhao, manlin/MVT-9587-2025; Chen,
   Yang/JNS-0000-2023
OI Liu, Hongyu/0000-0003-0383-8725; Chen, Yang/0000-0002-2808-6286
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NR 31
TC 1
Z9 1
U1 12
U2 12
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2213-2317
J9 REDOX BIOL
JI Redox Biol.
PD APR
PY 2025
VL 81
AR 103588
DI 10.1016/j.redox.2025.103588
EA MAR 2025
PG 10
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 0FM9F
UT WOS:001446140500001
PM 40073760
DA 2025-06-11
ER

PT J
AU Engh, JA
   Andersen, E
   Holmen, TL
   Martinsen, EW
   Mordal, J
   Morken, G
   Egeland, J
AF Engh, John A.
   Andersen, Eivind
   Holmen, Tom L.
   Martinsen, Egil W.
   Mordal, Jon
   Morken, Gunnar
   Egeland, Jens
TI Effects of high-intensity aerobic exercise on psychotic symptoms and
   neurocognition in outpatients with schizophrenia: study protocol for a
   randomized controlled trial
SO TRIALS
LA English
DT Article
DE High-intensity interval training; Schizophrenia; Psychosis;
   Neurocognition
ID DEPRESSION RATING-SCALE; ALCOHOL-USE DISORDERS; WELL-BEING INDEX;
   QUALITY-OF-LIFE; PHYSICAL-ACTIVITY; METABOLIC SYNDROME; CARDIOVASCULAR
   RISK; MODERATE EXERCISE; GLOBAL ASSESSMENT; NEGATIVE AFFECT
AB Background: The focus in recent years on physical inactivity and metabolic disturbances in individuals with schizophrenia raises the question of potential effects of physical activity. Physical activity has shown beneficial effects on cognition in healthy older individuals as well as on symptom severity in depression. However, opinions diverge regarding whether aerobic high-intensity interval training reduces cognition and key symptoms in schizophrenia. The main objective for the trial is to investigate the potential effects of aerobic high-intensity interval training on neurocognitive function and mental symptoms in outpatients with schizophrenia.
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C1 [Engh, John A.; Holmen, Tom L.; Mordal, Jon; Egeland, Jens] Vestfold Hosp Trust, Div Mental Hlth & Addict, Tonsberg, Norway.
   [Andersen, Eivind] Buskerud & Vestfold Univ Coll, Fac Humanities & Educ, Dept Pract Phys & Aesthet Educ, Borre, Norway.
   [Martinsen, Egil W.] Univ Oslo, Div Mental Hlth & Addict, Oslo Univ Hosp, Inst Clin Med, Oslo, Norway.
   [Morken, Gunnar] Norwegian Univ Sci & Technol NTNU, Fac Med, Dept Neurosci, Trondheim, Norway.
   [Morken, Gunnar] St Olavs Univ Hosp, Dept Psychiat, Trondheim, Norway.
   [Egeland, Jens] Univ Oslo, Dept Psychol, Oslo, Norway.
C3 University of South-Eastern Norway; University of Oslo; Norwegian
   University of Science & Technology (NTNU); Norwegian University of
   Science & Technology (NTNU); University of Oslo
RP Engh, JA (corresponding author), Vestfold Hosp Trust, Div Mental Hlth & Addict, Tonsberg, Norway.
EM john.engh@medisin.uio.no
RI Morken, Gunnar/AAX-3373-2020; Engh, John/AAG-6446-2021
OI Morken, Gunnar/0000-0003-1972-5901; Mordal, Jon/0009-0006-9868-2450
FU Vestfold Hospital Trust; Norwegian Extra Foundation for Health and
   Rehabilitation through EXTRA funds; Norwegian Research network in Severe
   Mental Illness (NORSMI); NORMENT/KG Jebsen Centre for Psychosis
   Research; Torgeir Lindvik's Trust; Civitan International
FX The investigators would like to give thanks to the patients
   participating in the feasibility study as well as the patients
   participating in the first part of the main trial. We owe many thanks to
   Therese Torgersen Bigseth and Rizwan Parvaiz in contributing to the
   recruitment of patients, carrying out the clinical testing, as well as
   to Merete Ronningen Bergstad, Helge Bjune, Ole Jakob Bredrup, Ellen
   Gurine Faervik, Jan Freddy Hovland, Camilla Lahn-Johannessen, Bjorn
   Einar Oscarsen, and Siri Oyhus for conducting the intervention. The
   trial has received funding from Vestfold Hospital Trust, Norwegian Extra
   Foundation for Health and Rehabilitation through EXTRA funds, Norwegian
   Research network in Severe Mental Illness (NORSMI), NORMENT/KG Jebsen
   Centre for Psychosis Research, Torgeir Lindvik's Trust, and Civitan
   International.
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NR 82
TC 24
Z9 27
U1 3
U2 55
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1745-6215
J9 TRIALS
JI Trials
PD DEC 8
PY 2015
VL 16
AR 557
DI 10.1186/s13063-015-1094-2
PG 12
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Research & Experimental Medicine
GA CY2PU
UT WOS:000366251400002
PM 26646670
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Alvarez, E
   Perez, V
   Artigas, F
AF Alvarez, Enric
   Perez, Victor
   Artigas, Francesc
TI Pharmacology and clinical potential of vortioxetine in the treatment of
   major depressive disorder
SO NEUROPSYCHIATRIC DISEASE AND TREATMENT
LA English
DT Review
DE depression; clinical trial; efficacy
ID 5 MG VORTIOXETINE; LU AA21004; DOUBLE-BLIND; MULTIMODAL COMPOUND;
   PLACEBO; ANTIDEPRESSANT; EFFICACY; ADULTS; TRIAL; TOLERABILITY
AB Vortioxetine is a new multimodal action antidepressant with two types of action: serotonin transporter (SERT) blockade and a strong affinity for several serotoninergic receptors. It is an antagonist of the 5-HT3 and 5-HT7 receptors, a partial agonist of 5-HT1B, and an agonist of 5-HT1A. Its combined action on SERT and four subtypes of serotoninergic receptors increases the extracellular concentration of serotonin, dopamine, and noradrenaline. Twelve clinical trials have been carried out, nine of which had positive results versus placebo. When active comparators were included in the study design, no significant differences were found except in one study in which the efficacy of vortioxetine was superior to the comparator (agomelatine) in depression resistant to selective serotonin reuptake inhibitors (SSRI)/serotonin-norepinephrine reuptake inhibitors (SNRI) treatment. Tolerability studies indicate that the drug does not cause any important problems on blood tests, vital signs, or on electrocardiography. The lack of weight gain and induction of metabolic syndrome and the lack of significant changes in the QTc are especially important. The incidence rate of sexual dysfunction is low and similar to placebo in various trials. Similarly, cognitive function remains intact with vortioxetine.
C1 [Alvarez, Enric] Univ Autonoma Barcelona, Hosp St Pau, Inst Recerca Biomed St Pau, Dept Psychiat, E-08193 Barcelona, Spain.
   [Alvarez, Enric; Perez, Victor; Artigas, Francesc] CIBERSAM, Minist Sci & Innovat, Madrid, Spain.
   [Artigas, Francesc] CSIC, Inst Invest Biomed Barcelona, Barcelona, Spain.
   [Perez, Victor] Univ Autonoma Barcelona, Hosp del Mar, Inst Neuropsiquiatria & Adicc, E-08193 Barcelona, Spain.
C3 Autonomous University of Barcelona; CIBER - Centro de Investigacion
   Biomedica en Red; CIBERSAM; Consejo Superior de Investigaciones
   Cientificas (CSIC); CSIC - Instituto de Investigaciones Biomedicas de
   Barcelona (IIBB); University of Barcelona; Autonomous University of
   Barcelona; Hospital del Mar Research Institute; Hospital del Mar
RP Alvarez, E (corresponding author), Hosp Santa Creu & Sant Pau, Dept Psychiat, Av St Antoni Ma Claret 167, Barcelona 08025, Spain.
EM ealvarezm@santpau.cat
RI Pérez Sola, Víctor/KBA-2879-2024; Artigas, Francesc/G-8500-2013
OI Perez Sola, Victor/0000-0002-5825-2337; Artigas,
   Francesc/0000-0002-5880-5720; Alvarez Martinez,
   Enric/0000-0002-5180-5541
FU Instituto de Salud Carlos III; Centro de Investigacion Biomedica en Red
   de Salud Mental; CIBERSAM; Spanish Ministry of Economy and
   Competitiveness [SAF 2012-35183]; European Regional Development Fund,
   ERDF
FX The study was supported by the Instituto de Salud Carlos III, Centro de
   Investigacion Biomedica en Red de Salud Mental, CIBERSAM, as well as
   grant SAF 2012-35183 to FA (Spanish Ministry of Economy and
   Competitiveness, co-financed by European Regional Development Fund,
   ERDF).
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NR 36
TC 58
Z9 61
U1 1
U2 21
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
EI 1178-2021
J9 NEUROPSYCH DIS TREAT
JI Neuropsychiatr. Dis. Treat.
PY 2014
VL 10
BP 1297
EP 1307
DI 10.2147/NDT.S41387
PG 11
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Psychiatry
GA AL3XK
UT WOS:000339064800001
PM 25075188
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Matsuda, M
   Tamura, R
   Kanno, K
   Segawa, T
   Kinoshita, H
   Nishimoto, O
   Nishiyama, H
   Kawamoto, T
AF Matsuda, Morihiro
   Tamura, Ritsu
   Kanno, Kotaro
   Segawa, Takatsugu
   Kinoshita, Haruyuki
   Nishimoto, Orie
   Nishiyama, Hirohiko
   Kawamoto, Toshiharu
TI Impact of dyslipidemic components of metabolic syndrome, adiponectin
   levels, and anti-diabetes medications on malondialdehyde-modified
   low-density lipoprotein levels in statin-treated diabetes patients with
   coronary artery disease
SO DIABETOLOGY & METABOLIC SYNDROME
LA English
DT Article
DE MDA-LDL; Metabolic syndrome; Triglycerides; HDL cholesterol;
   Adiponectin; Diabetes mellitus; Coronary artery disease; Statins
ID CIRCULATING OXIDIZED LDL; SYSTEMIC OXIDATIVE STRESS; C-REACTIVE PROTEIN;
   MYOCARDIAL-INFARCTION; OXIDATIVE/NITRATIVE STRESS;
   CARDIOVASCULAR-DISEASE; ENDOTHELIAL FUNCTION; FOLLOW-UP; RISK;
   CHOLESTEROL
AB Background: A residual risk of cardiovascular disease tends to persist despite standard prevention therapy with statins. This may stem partly from increased oxidized low-density lipoprotein (LDL) levels. However, how oxidized LDL can be further reduced beyond statin therapy in high-risk diabetes patients remains unclear. We aimed to clarify the clinical factors associated with oxidized LDL levels in statin-treated high-risk diabetes patients.
   Methods: This cross-sectional observational study included 210 diabetes patients with coronary artery diseases (CAD) who were treated with statins. We determined serum malondialdehyde-modified LDL (MDA-LDL), LDL cholesterol, high-density lipoprotein (HDL) cholesterol, triglyceride (TG), remnant lipoprotein cholesterol, hemoglobin (Hb) A(1c), adiponectin, and C-reactive protein (CRP) levels and investigated the factors influencing the MDA-LDL level.
   Results: In univariate analysis, the MDA-LDL level was significantly correlated with LDL cholesterol (p < 0.0001), TG (p < 0.0001), HDL cholesterol (p = 0.017), and adiponectin (p = 0.001) levels but not with age, body mass index, waist circumference, blood pressure, or HbA(1c) levels. Even after adjusting for the LDL cholesterol level, the correlations between the MDA-LDL level and the TG, HDL cholesterol, and adiponectin levels were still significant. Among these significant factors, multivariate analysis revealed that the MDA-LDL level was independently associated with the LDL cholesterol, TG, and HDL cholesterol but not with adiponectin levels. The MDA-LDL level was also significantly associated with the CRP level (p = 0.014) and the remnant lipoprotein cholesterol level (p < 0.0001) independently of the LDL cholesterol level. The number of metabolic syndrome (MS) components was significantly associated with the MDA-LDL/LDL cholesterol ratio (p < 0.0001). Furthermore, the use of metformin and a-glucosidase inhibitors was inversely associated with high MDA-LDL levels (p = 0.033 and 0.018, respectively).
   Conclusion: In statin-treated diabetes patients with CAD, the MDA-LDL level was significantly correlated with TG and HDL cholesterol levels. Adiponectin level was also significantly associated with the MDA-LDL level, but not independent of the above-mentioned factors. The management of dyslipidemic MS components, including the use of metformin or a-glucosidase inhibitors, may be important for reducing the oxidized LDL levels beyond statin therapy in high-risk diabetes patients.
C1 [Matsuda, Morihiro; Tamura, Ritsu; Kanno, Kotaro; Segawa, Takatsugu; Kinoshita, Haruyuki; Nishimoto, Orie; Nishiyama, Hirohiko; Kawamoto, Toshiharu] Natl Hosp Org Kure Med Ctr, Dept Cardiol, Kure, Hiroshima 7370023, Japan.
   [Matsuda, Morihiro; Tamura, Ritsu; Kanno, Kotaro; Segawa, Takatsugu; Kinoshita, Haruyuki; Nishimoto, Orie; Nishiyama, Hirohiko; Kawamoto, Toshiharu] Chugoku Canc Ctr, Kure, Hiroshima 7370023, Japan.
   [Matsuda, Morihiro] Natl Hosp Org Kure Med Ctr, Dept Internal Med, Kure, Hiroshima 7370023, Japan.
   [Matsuda, Morihiro] Natl Hosp Org Kure Med Ctr, Div Prevent Med, Inst Clin Res, Kure, Hiroshima 7370023, Japan.
RP Matsuda, M (corresponding author), Natl Hosp Org Kure Med Ctr, Dept Cardiol, 3-1 Aoyamacho, Kure, Hiroshima 7370023, Japan.
EM morihiro-m@kure-nh.go.jp
FU National Hospital Organization
FX We thank Noriko Okamoto for supporting the collection of clinical data
   and Naoko Kishida for technical support in measuring adiponectin levels.
   This study was financially supported by a Grant-in-Aid for Clinical
   Research from the National Hospital Organization.
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NR 50
TC 14
Z9 16
U1 0
U2 2
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1758-5996
J9 DIABETOL METAB SYNDR
JI Diabetol. Metab. Syndr.
PD DEC 6
PY 2013
VL 5
AR 77
DI 10.1186/1758-5996-5-77
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 289VK
UT WOS:000329710200001
PM 24314067
OA gold, Green Accepted
DA 2025-06-11
ER

PT J
AU Hoyos, CM
   Drager, LF
   Patel, SR
AF Hoyos, Camilla M.
   Drager, Luciano F.
   Patel, Sanjay R.
TI OSA and cardiometabolic risk: What's the bottom line?
SO RESPIROLOGY
LA English
DT Review
DE cardiovascular diseases; metabolic diseases; randomized controlled
   trials; sleep apnoea; obstructive
ID OBSTRUCTIVE SLEEP-APNEA; POSITIVE AIRWAY PRESSURE;
   CORONARY-ARTERY-DISEASE; C-REACTIVE PROTEIN; CHRONIC INTERMITTENT
   HYPOXIA; RANDOMIZED CONTROLLED-TRIAL; FLOW-MEDIATED DILATION; OXIDATIVE
   STRESS; INSULIN-RESISTANCE; CARDIOVASCULAR EVENTS
AB Obstructive sleep apnoea (OSA) is a common condition characterized by repetitive upper airway obstruction during sleep. OSA promotes wide intrathoracic pressure swings, intermittent hypoxia and sleep fragmentation. Growing evidence derived from animal models mimicking the oxygen profile observed in patients with OSA as well as clinical studies support that this important sleep-disordered breathing is associated with increased cardiovascular risk. Although the precise mechanisms are not fully established, it is conceivable that the metabolic deregulation promoted by the components of OSA may have an important causal role in the poor cardiovascular prognosis. In this review, we summarize the potential role of OSA and its components on cardiometabolic disease. We also summarize evidence evaluating the impact of OSA treatment (notably continuous positive airway pressure) on reversing the metabolic deregulation promoted by OSA. Finally, we discuss the research agenda and perspectives for this important research area.
C1 [Hoyos, Camilla M.] Univ Sydney, Woolcock Inst Med Res, Ctr Sleep & Chronobiol, POB M77, Sydney, NSW 2050, Australia.
   [Hoyos, Camilla M.] Univ Sydney, Fac Sci, Sch Psychol, Hlth Brain Ageing Program, Sydney, NSW, Australia.
   [Drager, Luciano F.] Univ Sao Paulo, Sch Med, Heart Inst InCor, Hypertens Unit, Sao Paulo, Brazil.
   [Patel, Sanjay R.] Univ Pittsburgh, Dept Med, Div Pulm Allergy & Crit Care Med, Pittsburgh, PA USA.
C3 University of Sydney; Woolcock Institute of Medical Research; University
   of Sydney; Universidade de Sao Paulo; Pennsylvania Commonwealth System
   of Higher Education (PCSHE); University of Pittsburgh
RP Hoyos, CM (corresponding author), Univ Sydney, Woolcock Inst Med Res, Ctr Sleep & Chronobiol, POB M77, Sydney, NSW 2050, Australia.
EM camilla.hoyos@sydney.edu.au
RI Drager, Luciano/A-1535-2014; Hoyos, Camilla/LYP-0519-2024
OI Hoyos, Camilla/0000-0002-6543-4016; Patel, Sanjay/0000-0002-9142-5172;
   Drager, Luciano/0000-0002-2081-6846
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NR 120
TC 28
Z9 29
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1323-7799
EI 1440-1843
J9 RESPIROLOGY
JI Respirology
PD APR
PY 2017
VL 22
IS 3
BP 420
EP 429
DI 10.1111/resp.12984
PG 10
WC Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Respiratory System
GA EQ3BY
UT WOS:000397947200004
PM 28161892
OA Bronze
DA 2025-06-11
ER

PT J
AU Ramos-Lopez, O
AF Ramos-Lopez, Omar
TI Epigenetic Biomarkers of Metabolic Responses to Lifestyle Interventions
SO NUTRIENTS
LA English
DT Review
DE epigenetics; biomarkers; metabolic alterations; DNA methylation; histone
   modifications; miRNAs; precision nutrition
ID DNA METHYLATION; WEIGHT-LOSS; SUPPLEMENTATION; ASSOCIATION; MARKERS;
   HEALTH; GENES; DIET
AB Studies have examined the possible utility of epigenetic phenomena (DNA methylation changes, covalent histone modifications, and miRNA expression patterns) in predicting individual responses to different lifestyle programs. Nonetheless, most available evidence is focused on identifying epigenetic marks eventually associated with body composition and adiposity outcomes, whereas their roles in metabolic endings remain less explored. This document comprehensively reviewed the evidence regarding the use of epigenetic signatures as putative biomarkers of metabolic outcomes (glycemic, lipid, blood pressure, and inflammatory/oxidative stress features) in response to different lifestyle interventions in humans. Although more investigation is still necessary in order to translate this knowledge in clinical practice, these scientific insights are contributing to the design of advanced strategies for the precise management of cardiometabolic risk, gaining understanding on metabolic heterogeneity, allowing for the prediction of metabolic outcomes, and facilitating the design of epigenome-based nutritional strategies for a more customized approach for metabolic alterations treatment under the scope of precision nutrition.
C1 [Ramos-Lopez, Omar] Autonomous Univ Baja California, Med & Psychol Sch, Tijuana 22390, Mexico.
C3 Universidad Autonoma de Baja California
RP Ramos-Lopez, O (corresponding author), Autonomous Univ Baja California, Med & Psychol Sch, Tijuana 22390, Mexico.
EM oscar.omar.ramos.lopez@uabc.edu.mx
RI LÓPEZ, OSCAR/ABH-6978-2020
OI Ramos Lopez, Omar/0000-0002-2505-1555
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NR 61
TC 3
Z9 3
U1 1
U2 7
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD OCT
PY 2023
VL 15
IS 19
AR 4251
DI 10.3390/nu15194251
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA U3FW9
UT WOS:001083701100001
PM 37836535
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Hong, YC
   Park, EY
   Park, MS
   Ko, JA
   Oh, SY
   Kim, H
   Lee, KH
   Leem, JH
   Ha, EH
AF Hong, Yun-Chul
   Park, Eun-Young
   Park, Min-Seon
   Ko, Jeong Ah
   Oh, Se-Young
   Kim, Ho
   Lee, Kwan-Hee
   Leem, Jong-Han
   Ha, Eun-Hee
TI Community level exposure to chemicals and oxidative stress in adult
   population
SO TOXICOLOGY LETTERS
LA English
DT Article
DE Environmental chemical exposure; Oxidative stress; Insulin resistance;
   Metabolic syndrome; Diabetes mellitus
ID POLYCYCLIC AROMATIC-HYDROCARBONS; BISPHENOL-A;
   2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN TCDD; PHTHALATE METABOLITES;
   INSULIN-RESISTANCE; EPIDIDYMAL SPERM; DNA-DAMAGE; ASSOCIATION;
   POLLUTANTS; POLLUTION
AB Little information is available on the role of environmental chemical exposure in oxidative stress. This study was designed to investigate whether exposure to environmental chemicals, such as polycylic aromatic hydrocarbons, volatile organic compounds, bisphenol A or phthalates, induces oxidative stress in urban adult Populations. A total of 960 adults dwelling in urban areas were evaluated between April and December 2005. To assess environmental chemical exposure, we measured urinary levels of 1-hydroxypyrene, 2-naphthol, hippuric acid, methyl hippuric acid, mono-(2-ethyl-5-hydroxyhexyl) phthalate, mono-(2-ethyl-5-oxohexyl) phthalate, and mono-butyl phthalate and bisphenol A. Urinary malondialdehyde and 8-hydroxydeoxyguanosine were also measured to evaluate oxidative stress. Significant dose-responsive relationship was found between Urinary concentrations of the chemical exposure biomarkers and oxidative stress levels in simple regression analyses (P < 0.05). Regression coefficients of these exposure biomarkers except bisphenol A remained significantly in the multiple regression models, after controlling for age, sex, weight, smoking, and exercise for at feast one of the two oxidative stress biomarkers (P < 0.05). The oxidative stress biomarkers significantly affected the indicators of insulin resistance, particularly glucose level. This study indicates that environmental chemical exposure is associated with oxidative stress in urban adult populations and suggests that exposure to certain environmental chemicals might contribute to insulin resistance. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
C1 [Ha, Eun-Hee] Ewha Womans Univ, Sch Med, Dept Prevent Med, Seoul, South Korea.
   [Hong, Yun-Chul; Park, Eun-Young] Seoul Natl Univ, Coll Med, Dept Prevent Med, Seoul, South Korea.
   [Hong, Yun-Chul] Seoul Natl Univ, Med Res Ctr, Inst Environm Med, Seoul, South Korea.
   [Park, Min-Seon; Ko, Jeong Ah] Seoul Natl Univ Hosp, Dept Family Med, Seoul 110744, South Korea.
   [Oh, Se-Young] Kyung Hee Univ, Dept Food & Nutr, Seoul, South Korea.
   [Kim, Ho] Seoul Natl Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Seoul, South Korea.
   [Lee, Kwan-Hee; Leem, Jong-Han] Inha Univ Hosp, Dept Occupat & Environm Med, Inchon, South Korea.
C3 Ewha Womans University; Seoul National University (SNU); Seoul National
   University (SNU); Seoul National University (SNU); Seoul National
   University Hospital; Kyung Hee University; Seoul National University
   (SNU); Inha University; Inha University Hospital
RP Ha, EH (corresponding author), Ewha Womans Univ, Sch Med, Dept Prevent Med, Seoul, South Korea.
EM eunheeha@ewha.ac.kr
RI Hong, Yun-Chul/J-5725-2012; Lee, Sang Jin/S-4056-2019; Kim,
   Hwan-Cheol/GYR-0244-2022; Kim, Ho/AAS-2402-2021
OI Kim, Ho/0000-0001-7472-3752
FU Korea Institute of Environmental Science and Technology
FX This study was supported by the Eco-technopia 21 Project of Korea
   Institute of Environmental Science and Technology.
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NR 40
TC 134
Z9 145
U1 1
U2 35
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0378-4274
EI 1879-3169
J9 TOXICOL LETT
JI Toxicol. Lett.
PD JAN 30
PY 2009
VL 184
IS 2
BP 139
EP 144
DI 10.1016/j.toxlet.2008.11.001
PG 6
WC Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Toxicology
GA 405JU
UT WOS:000263219900011
PM 19049859
DA 2025-06-11
ER

PT J
AU de Oliveira, LFN
   Maia, CSC
   Nogueira, MDD
   Dias, TD
   Firmino, MAD
   Loureiro, APD
   Marzola, EL
   Nunes, PIG
   Santos, FA
   Freire, WBD
   Fortunato, RS
   Loureiro, ACC
AF de Oliveira, Luis Felipe Nunes
   Maia, Carla Soraya Costa
   Nogueira, Maria Dinara de Araujo
   Dias, Thaynan dos Santos
   Firmino, Matheus Aragao Dias
   Loureiro, Ana Paula de Melo
   Marzola, Elisabete Leide
   Nunes, Paulo Iury Gomes
   Santos, Flavia Almeida
   Freire, Walter Breno de Souza
   Fortunato, Rodrigo Soares
   Loureiro, Adriano Cesar Carneiro
TI Cashew nut consumption reduces waist circumference and oxidative stress
   in adolescents with obesity: A randomized clinical trial
SO NUTRITION RESEARCH
LA English
DT Article
DE Cashew nut; Anthropometry; Body composition; Oxidative stress;
   Adolescents
ID ADIPOSE-TISSUE; INDEXES; DIET
AB Previous evidence suggests that certain types of nuts, when included in a healthy diet pattern, may provide health benefits. Therefore, we hypothesize that the consumption of cashew nuts associated with a healthy diet may enhance antioxidant defenses and improve anthropometric and body composition parameters in individuals with obesity. We conducted a 12-week randomized clinical trial, divided into 4 sessions, involving adolescents randomly assigned to receive either 30 g of roasted cashew nuts together with nutrition education (cashew nut group-CNG) or only nutrition education (control group-CG). The total number of participants who started the study was 142, with 77 in the CNG and 65 in the CG. Data on anthropometry, body composition, and oxidative stress were collected at baseline (0-week) and endpoint (12-week). The main post-intervention findings in the CNG showed decreases in waist circumference (WC), thiobarbituric acid reactive substances (TBARS) and total antioxidant capacity (TAC) at 60 minutes in the CNG, while neck circumference (NC) increased. However, the CG showed an increase in TBARS and percentage of lean body mass (LBM), along with reduction in TAC at 60 minutes. After 12 weeks, the consumption of cashew nuts seemed to assist in WC reduction, even without a decrease in other anthropometric parameters, thereby decreasing the cardiometabolic risk. Furthermore, the consumption of cashew nuts demonstrated the ability to decrease overall oxidative damage as assessed by TBARS, a finding that reinforces the effects of this nut consumption against systemic oxidative stress associated with obesity. (c) 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.
C1 [de Oliveira, Luis Felipe Nunes; Maia, Carla Soraya Costa; Dias, Thaynan dos Santos; Firmino, Matheus Aragao Dias; Loureiro, Adriano Cesar Carneiro] Univ Estadual Ceara, Hlth & Nutr Postgrad Program, Fortaleza, CE, Brazil.
   [Nogueira, Maria Dinara de Araujo] Univ Estadual Ceara, Postgrad Program Publ Hlth, Fortaleza, CE, Brazil.
   [Loureiro, Ana Paula de Melo] Univ Sao Paulo, Fac Pharmaceut Sci, Sao Paulo, SP, Brazil.
   [Marzola, Elisabete Leide] Univ Sao Paulo, Postgrad Program Pathophysiol & Toxicol, Fac Pharmaceut Sci, Sao Paulo, SP, Brazil.
   [Nunes, Paulo Iury Gomes] Univ Fed Ceara, Sch Med, Postgrad Program Med Sci, Fortaleza, CE, Brazil.
   [Santos, Flavia Almeida] Univ Fed Ceara, Sch Med, Dept Physiol & Pharmacol, Nat Prod Lab, Fortaleza, CE, Brazil.
   [Freire, Walter Breno de Souza] Univ Fortaleza, Clin Anal Lab, Fortaleza, CE, Brazil.
   [Fortunato, Rodrigo Soares] Univ Fed Rio de Janeiro, Postgrad Program Biol Sci, Rio De Janeiro, RJ, Brazil.
C3 Universidade Estadual do Ceara; Universidade Estadual do Ceara;
   Universidade de Sao Paulo; Universidade de Sao Paulo; Universidade
   Federal do Ceara; Universidade Federal do Ceara; Universidade Fortaleza;
   Universidade Federal do Rio de Janeiro
RP Maia, CSC (corresponding author), State Univ Ceara UECE, Postgrad Program Nutr & Hlth, 1700 Campus Itaperi, BR-60714903 Fortaleza, CE, Brazil.; Maia, CSC (corresponding author), State Univ Ceara UECE, Postgrad Program Publ Hlth, 1700 Campus Itaperi, BR-60714903 Fortaleza, CE, Brazil.
EM carla.maia@uece.br
RI Loureiro, Ana/C-9237-2012; Marzola, Elisabete Leide/AGS-8904-2022;
   Nogueira, Dinara/HGV-1067-2022; Santos, Flavia/S-5321-2016; Nunes,
   Paulo/F-5873-2016; Maia, Carla Soraya/AHC-5903-2022; Fortunato,
   Rodrigo/AAM-9931-2020
FU Research Program for the BrazilianUnified Health System (PPSUS) of the
   Ceara Foundation for Support to Scientific and Technological Development
   (FUNCAP) [900394/2020]; National Council for Scientific and
   Technological Development - CNPq
FX This study received financial support from the Research Program for the
   BrazilianUnified Health System (PPSUS-Agreement No. 900394/2020) of the
   Ceara Foundation for Support to Scientific and Technological Development
   (FUNCAP) , and by the Academic Master's and Doctorate Program for
   Innovation (MAI/DAI) funded by the National Council for Scientific and
   Technological Development - CNPq .
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NR 46
TC 0
Z9 0
U1 3
U2 3
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0271-5317
EI 1879-0739
J9 NUTR RES
JI Nutr. Res.
PD FEB
PY 2025
VL 134
BP 60
EP 72
DI 10.1016/j.nutres.2024.12.009
EA JAN 2025
PG 13
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA U3E4S
UT WOS:001410665500001
PM 39862524
DA 2025-06-11
ER

PT J
AU Ndrepepa, G
AF Ndrepepa, Gjin
TI Myeloperoxidase - A bridge linking inflammation and oxidative stress
   with cardiovascular disease
SO CLINICA CHIMICA ACTA
LA English
DT Review
DE Cardiovascular disease; inflammation; mortality; myeloperoxidase;
   oxidative stress
ID CORONARY-ARTERY-DISEASE; C-REACTIVE PROTEIN; NEUTROPHIL EXTRACELLULAR
   TRAPS; ANKLE-BRACHIAL INDEX; APOLIPOPROTEIN-A-I; PLASMA MYELOPEROXIDASE;
   SERUM MYELOPEROXIDASE; HYPOCHLOROUS ACID; ENDOTHELIAL-CELLS; PROGNOSTIC
   VALUE
AB Myeloperoxidase (MPO) is a member of the superfamily of heme peroxidases that is mainly expressed in neutrophils and monocytes. MPO-derived reactive species play a key role in neutrophil antimicrobial activity and human defense against various pathogens primarily by participating in phagocytosis. Elevated MPO levels in circulation are associated with inflammation and increased oxidative stress. Multiple lines of evidence suggest an association between MPO and cardiovascular disease (CVD) including coronary artery disease, congestive heart failure, arterial hypertension, pulmonary arterial hypertension, peripheral arterial disease, myocardial ischemia/reperfusion-related injury, stroke, cardiac arrhythmia and venous thrombosis. Elevated MPO levels are associated with a poor prognosis including increased risk for overall and CVD-related mortality. Elevated MPO may signify an increased risk for CVD for at least 2 reasons. First, low-grade inflammation and increased oxidative stress coexist with many metabolic abnormalities and comorbidities and consequently an elevated MPO level may represent an increased cardiometabolic risk in general. Second, MPO produces a large number of highly reactive species which can attack, destroy or modify the function of every known cellular component. The most common MPO actions relevant to CVD are generation of dysfunctional lipoproteins with an increased atherogenicity potential, reduced NO availability, endothelial dysfunction, impaired vasoreactivity and atherosclerotic plaque instability. These actions strongly suggest that MPO is directly involved in the pathophysiology of CVD. In this regard MPO may be seen as a mediator or an instrument through which inflammation promotes CVD at molecular and cellular level. Clinical value of MPO therapeutic inhibition remains to be tested.
C1 [Ndrepepa, Gjin] Tech Univ, Dept Adult Cardiol, Deutsch Herzzentrum Munchen, Lazarettstr 36, D-80636 Munich, Germany.
C3 Technical University of Munich; German Heart Centre Munich
RP Ndrepepa, G (corresponding author), Tech Univ, Dept Adult Cardiol, Deutsch Herzzentrum Munchen, Lazarettstr 36, D-80636 Munich, Germany.
EM ndrepepa@dhm.mhn.de
OI Ndrepepa, Gjin/0000-0002-8725-055X
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NR 191
TC 325
Z9 356
U1 4
U2 98
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0009-8981
EI 1873-3492
J9 CLIN CHIM ACTA
JI Clin. Chim. Acta
PD JUN
PY 2019
VL 493
BP 36
EP 51
DI 10.1016/j.cca.2019.02.022
PG 16
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA HW6TQ
UT WOS:000466823900007
PM 30797769
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Chiang, SL
   Chiang, LC
   Tzeng, WC
   Lee, MS
   Fang, CC
   Lin, CH
   Lin, CH
AF Chiang, Shang-Lin
   Chiang, Li-Chi
   Tzeng, Wen-Chii
   Lee, Meei-Shyuan
   Fang, Chan-Chuan
   Lin, Chueh-Ho
   Lin, Chia-Huei
TI Impact of Rotating Shifts on Lifestyle Patterns and Perceived Stress
   among Nurses: A Cross-Sectional Study
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Article
DE lifestyle pattern; perceived stress; rotating shift; shift work; sleep
   pattern; sleep quality
ID PHYSICAL-ACTIVITY; METABOLIC SYNDROME; SLEEP DURATION; NIGHT-SHIFT;
   CANCER SURVIVORS; WORK; HEALTH; METAANALYSIS; RISK; BEHAVIORS
AB Although rotating shifts have a negative health impact, their association with hospital nurses' health risks remains controversial due to incomplete adjustment in lifestyle patterns and heterogeneity of work schedules. However, whether work schedule characteristics are associated with lifestyle patterns and perceived stress remains undetermined. We assessed the correlations of work schedule characteristics, lifestyle patterns, and perceived stress among hospital nurses. This cross-sectional study included 340 nurses from two hospitals. Final data from 329 nurses regarding work schedule characteristics, lifestyle patterns (physical activity, dietary behavior, and sleep pattern), and perceived stress were analyzed via linear regression models. Fixed-day-shift nurses had reduced perceived stress (beta = 0.15, p = 0.007) compared with rotating-shift nurses. Additionally, among rotating-shift nurses, fixed-evening- and fixed-night-shift nurses had longer sleep duration (beta = 0.27, p < 0.001; beta = 0.25, p < 0.001) compared to non-fixed-rotating-shift nurses. Longer rotating-shift work was associated with healthier dietary behaviors (beta = 0.15, p = 0.008), better sleep quality (beta = -0.17, p = 0.003), lower perceived stress (beta = -0.24, p < 0.001), and shorter sleep duration (beta = -0.17, p = 0.003). Hospital nurses' work schedule characteristics were associated with lifestyle patterns, dietary behavior, sleep pattern, and perceived stress. Fixed-shifts were beneficial for lifestyle and lower perceived stress. Longer rotating shifts could help nurses adjust their lifestyles accordingly.
C1 [Chiang, Shang-Lin] Natl Def Med Ctr, Sch Med, Taipei 11490, Taiwan.
   [Chiang, Shang-Lin] Triserv Gen Hosp, Dept Phys Med & Rehabil, Taipei 11490, Taiwan.
   [Chiang, Li-Chi; Tzeng, Wen-Chii; Lin, Chia-Huei] Natl Def Med Ctr, Sch Nursing, Taipei 11490, Taiwan.
   [Chiang, Li-Chi] China Med Univ, Sch Nursing, Taichung 40402, Taiwan.
   [Lee, Meei-Shyuan] Natl Def Med Ctr, Sch Publ Hlth, Taipei 11490, Taiwan.
   [Fang, Chan-Chuan] Yuan Rung Hosp, Dept Nursing, Changhua 51045, Taiwan.
   [Lin, Chueh-Ho] Taipei Med Univ, Coll Nursing, Master Program Long Term Care, Taipei 110301, Taiwan.
   [Lin, Chueh-Ho] Taipei Med Univ, Wan Fang Hosp, Ctr Nursing & Healthcare Res Clin Practice Applic, Taipei 11031, Taiwan.
   [Lin, Chia-Huei] Triserv Gen Hosp, Dept Nursing, Taipei 11490, Taiwan.
C3 National Defense Medical Center; Tri-Service General Hospital; National
   Defense Medical Center; China Medical University Taiwan; National
   Defense Medical Center; Taipei Municipal WanFang Hospital; Taipei
   Medical University; Tri-Service General Hospital
RP Lin, CH (corresponding author), Natl Def Med Ctr, Sch Nursing, Taipei 11490, Taiwan.; Lin, CH (corresponding author), Triserv Gen Hosp, Dept Nursing, Taipei 11490, Taiwan.
EM andyyy520@yahoo.com.tw; lichichiang@gmail.com;
   wctzeng@mail.ndmctsgh.edu.tw; meei.shyuan@msa.hinet.net;
   jane_f56@yahoo.com.tw; chueh.ho@tmu.edu.tw;
   andyy520@mail.ndmctsgh.edu.tw
RI Lin, Chia-Huei/GLQ-5499-2022; Chiang, Li-Chi/AAW-9661-2020; Tzeng,
   Wen-Chii/M-4214-2014
OI Chiang, Shang-Lin/0000-0003-1210-626X; Chiang,
   Li-Chi/0000-0002-6383-7495; Lin, Chueh-Ho/0000-0001-9952-6202; Lin,
   Chia-Huei/0000-0003-3751-602X; Tzeng, Wen-Chii/0000-0002-4205-896X
FU Taiwan Nurses Association [TWNA-1071005]; Tri-Service General Hospital
   [TSGH-SS-D-109023, TSGH-E-111243]; Taipei, Taiwan
FX This study was funded by Taiwan Nurses Association (grant numbers:
   TWNA-1071005) and Tri-Service General Hospital (TSGH-SS-D-109023;
   TSGH-E-111243), Taipei, Taiwan.
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NR 44
TC 13
Z9 14
U1 6
U2 24
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD MAY
PY 2022
VL 19
IS 9
AR 5235
DI 10.3390/ijerph19095235
PG 11
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA 1E6SL
UT WOS:000794615700001
PM 35564629
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Tamez, M
   Ríos-Bedoya, CF
   Rodríguez-Orengo, JF
   Tucker, KL
   Mattei, J
AF Tamez, Martha
   Rios-Bedoya, Carlos F.
   Rodriguez-Orengo, Jose F.
   Tucker, Katherine L.
   Mattei, Josiemer
TI Sociodemographic and Lifestyle Factors, and Health Conditions of
   Dominican Adults Living in Puerto Rico
SO JOURNAL OF IMMIGRANT AND MINORITY HEALTH
LA English
DT Article
DE Dominicans; Puerto Ricans; Health disparities; Chronic diseases;
   Minority health
ID US HISPANIC/LATINO ADULTS; DISEASE RISK-FACTORS; CARDIOVASCULAR-DISEASE;
   UNITED-STATES; PSYCHOLOGICAL DISTRESS; DEPRESSIVE SYMPTOMS; DIVERSE
   BACKGROUNDS; METABOLIC SYNDROME; SOCIAL SUPPORT; PREVALENCE
AB Dominicans are the largest migrant community in Puerto Rico, yet understudied. We compared risk factors and health conditions of Dominicans versus Puerto Ricans (PRs). Cross-sectional survey of Dominicans (n=55) and PRs (n=310) aged 30-75years, assessed with validated questionnaires and standardized anthropometric measurements. Significantly, more Dominicans than PRs had attained <8th grade education (37.7 vs. 8.0%), reported household income $10,000 (76.1 vs. 56.9%), lacked health insurance (19.6 vs. 5.5%), and reported food insecurity (24.5 vs. 12.1%). They spent fewer hours/day watching television (2.9 vs. 3.8), and were less likely to smoke (7.6 vs. 19.6%). Medically-diagnosed depression was lower among Dominicans than PRs (9.6 vs. 23.0%); questionnaire-based high depressive symptomatology was similar (47.9 vs. 52.8%). Dominicans living in Puerto Rico had more socioeconomic risk factors but healthier lifestyle behaviors and lower prevalence of medically-diagnosed depression than PRs. Tailored approaches are needed to ameliorate disparities in each ethnic group.
C1 [Tamez, Martha; Mattei, Josiemer] Harvard TH Chan Sch Publ Hlth, Dept Nutr, 665 Huntington Ave,Bldg 2, Boston, MA 02115 USA.
   [Rios-Bedoya, Carlos F.; Rodriguez-Orengo, Jose F.] Fdn Invest Puerto Rico, San Juan, PR USA.
   [Rios-Bedoya, Carlos F.] Hurley Med Ctr, Dept Internal Med, Flint, MI USA.
   [Rodriguez-Orengo, Jose F.] Univ Puerto Rico, Dept Biochem, Sch Med, Rio Piedras, PR USA.
   [Tucker, Katherine L.] Univ Massachusetts Lowell, Dept Biomed & Nutr Sci, Lowell, MA USA.
C3 Harvard University; Harvard T.H. Chan School of Public Health;
   University of Puerto Rico; University of Puerto Rico Medical Sciences
   Campus; University of Massachusetts System; University of Massachusetts
   Lowell
RP Mattei, J (corresponding author), Harvard TH Chan Sch Publ Hlth, Dept Nutr, 665 Huntington Ave,Bldg 2, Boston, MA 02115 USA.
EM jmattei@hsph.harvard.edu
RI Tucker, Katherine/A-4545-2010; Mattei, Josiemer/H-1800-2016
OI Mattei, Josiemer/0000-0001-5424-8245; Tucker,
   Katherine/0000-0001-7640-662X; Tamez, Martha/0000-0003-3164-1647
FU Northarvest Bean Growers Association; Fundacion de Investigacion;
   NIH-National Heart Lung and Blood Institute [K01-HL120951]; National
   Council of Science and Technology (CONACyT, Mexico)
FX The Puerto Rico Assessment of Diet, Lifestyle, and Diseases study was
   successful thanks to the contribution from all our interviewers, the
   staff at the partner clinics, and the participants. This study was
   funded by private anonymous donations to Harvard T.H. Chan School of
   Public Health, a Dry Bean Health Research Program Incentive Award from
   the Northarvest Bean Growers Association, and institutional funds from
   Fundacion de Investigacion. Additional funding was received from a
   Mentored Career Development Award to Promote Faculty Diversity in
   Biomedical Research (K01-HL120951) from the NIH-National Heart Lung and
   Blood Institute. MT was funded by the National Council of Science and
   Technology (CONACyT, Mexico).
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NR 54
TC 2
Z9 2
U1 1
U2 8
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1557-1912
EI 1557-1920
J9 J IMMIGR MINOR HEALT
JI J. Immigr. Minor. Health
PD OCT
PY 2018
VL 20
IS 5
BP 1085
EP 1093
DI 10.1007/s10903-017-0637-x
PG 9
WC Public, Environmental & Occupational Health
WE Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA GS9LV
UT WOS:000444041100007
PM 28808807
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Kuo, SY
   Liu, PH
   Chuang, LM
   Chen, WJ
AF Kuo, Shu-Yu
   Liu, Pi-Hua
   Chuang, Lee-Ming
   Chen, Wei J.
TI The Taipei Adolescent Twin/Sibling Family Study II: Depression, insulin
   resistance, and hormonal factors
SO TWIN RESEARCH AND HUMAN GENETICS
LA English
DT Article
ID METABOLIC SYNDROME; LEPTIN LEVELS; OBESITY; RISK; SYMPTOMS; FEATURES;
   TYPE-2; TWINS
AB In this ongoing longitudinal study of adolescent twins/sibling pairs and their parents in Taipei, we aimed to investigate the genetic and environmental influences on adolescent behavioral development, metabolic risk factors, and the associations between the two. Special focus is on anxious depression, metabolic profile, and hormonal factors such as cortisol and leptin. The first wave of assessment was completed during the period of 2002 to 2005 and included 192 twin pairs, 6 triplets, 56 sibling pairs and their first-degree relatives (484 parents and 142 siblings). We are currently in the process of a second wave assessment as follow-up. Dimensional psychological assessments using self-report questionnaires, as well as categorical assessments based on semistructured clinical interviews, were performed. All subjects received a 2-hour oral glucose tolerance test at the examination site. The metabolic phenotypes including body mass index, blood pressure, levels of glucose, insulin, and lipid profile as well as related hormonal levels were measured. Zygosity was determined using DNA, except for a few twins whose DNA was not available. Such a combination of detailed psychological assessments and metabolic function tests is expected to help shed light on the interrelation of psychological well-being and metabolic functioning.
C1 Natl Taiwan Univ, Coll Publ Hlth, Inst Epidemiol, Taipei 100, Taiwan.
   Natl Taiwan Univ, Coll Med, Dept Internal Med, Taipei, Taiwan.
   Natl Taiwan Univ, Natl Taiwan Univ Hosp, Taipei 10764, Taiwan.
   Natl Taiwan Univ, Coll Med, Dept Psychiat, Taipei 10764, Taiwan.
C3 National Taiwan University; National Taiwan University; National Taiwan
   University; National Taiwan University Hospital; National Taiwan
   University
RP Chen, WJ (corresponding author), Natl Taiwan Univ, Coll Publ Hlth, Inst Epidemiol, 17 Xu Zhou Rd, Taipei 100, Taiwan.
EM weijen@ha.mc.ntu.edu.tw
RI Chen, Su-Hwei/C-4933-2009; Chuang, Lee-Ming/AAF-3324-2019
OI Liu, Pi-Hua/0000-0002-7165-6248; Chen, Wei Jen/0000-0001-5899-5870;
   CHUANG, LEE-MING/0000-0003-0978-2662; Kuo, Shu-Yu/0000-0003-4221-7673
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NR 22
TC 3
Z9 3
U1 0
U2 7
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
SN 1832-4274
EI 1839-2628
J9 TWIN RES HUM GENET
JI Twin Res. Hum. Genet.
PD DEC
PY 2006
VL 9
IS 6
BP 895
EP 898
DI 10.1375/183242706779462840
PG 4
WC Genetics & Heredity; Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Genetics & Heredity; Obstetrics & Gynecology
GA 122HO
UT WOS:000243216600034
PM 17254427
OA Bronze
DA 2025-06-11
ER

PT J
AU Fu, YD
   Jiang, C
   Li, ZL
   Shi, XY
   Lv, PY
   Zhang, JB
AF Fu, Yidian
   Jiang, Chao
   Li, Zonglin
   Shi, Xiangyun
   Lv, Peiyuan
   Zhang, Jingbo
TI Association between the composite dietary antioxidant index and
   non-alcoholic fatty liver disease: evidence from National Health and
   Nutrition Examination Survey 2005-2016
SO FRONTIERS IN NUTRITION
LA English
DT Article
DE composite dietary antioxidant index; non-alcoholic fatty liver disease;
   NHANES; US fatty liver index; hepatic steatosis index
ID OXIDATIVE STRESS; VITAMIN-E; AMERICAN ASSOCIATION; METABOLIC SYNDROME;
   HEPATIC STEATOSIS; UNITED-STATES; RISK-FACTORS; STEATOHEPATITIS;
   MANAGEMENT; DIAGNOSIS
AB Importance Oxidative stress contributes to the progression of non-alcoholic fatty liver disease (NAFLD). Antioxidants from food can reduce NAFLD incidence, and the Composite Dietary Antioxidant Index (CDAI) measures total antioxidant capacity (TAC). However, the relationship between CDAI and NAFLD in the US adult population remains unclear. Objective To assess whether CDAI is associated with NAFLD in US adults. Design, setting, and participants This population-based cross-sectional study used data on US adults from the National Health and Nutrition Examination Survey (NHANES) 2005-2016 cycles. Data were analyzed from January to February 2024. Exposures CDAI obtained from the dietary intake questionnaire. Main outcomes and measures The main outcome was NAFLD which defined by the US fatty liver score (USFLI) >= 30. Sampling weights were calculated according to NHANES guidelines. Results Among 9,746 adults included in this study [mean age, 48.3 years; 4,662 (47.6%) males], 3,324 (33.0%) were classified as having NAFLD using USFLI. In the fully adjusted of multivariable logistic regression, CDAI was negatively associated with NAFLD (odds ratio [OR], 0.95; 95% CI, 0.93-0.98). Furthermore, individuals in the highest quartile of CDAI were 34% less likely to have NAFLD compared to those in the lowest quartile (OR, 0.66; 95% CI, 0.52-0.85). In subgroup analyses, CDAI was inversely associated with NAFLD among participants with a BMI <25 (OR, 0.89; 95% CI, 0.83-0.95) and without metabolic syndrome (OR, 0.93; 95% CI, 0.91-0.96). The interaction tests revealed significant differences in these subgroups (P for interaction = 0.04 for BMI and 0.003 for metabolic syndrome). Sensitivity analyses confirmed this association using the hepatic steatosis index (HSI) to define NAFLD, applying unweighted logistic regression, adjusting for physical activity or after excluding non-Hispanic Black participants, and after excluding medications known for their potential hepatotoxic effects. Conclusions and relevance In this cross-sectional study based on six cycles (2005-2016) of the NHANES, CDAI was negatively associated with NAFLD in US adult population. This association highlights the potential for dietary interventions to reduce NAFLD incidence and underscores the need for future research, including clinical trials and mechanistic studies, to further explore the role of dietary antioxidants in NAFLD prevention and management.
C1 [Fu, Yidian; Lv, Peiyuan] Hebei Med Univ, Sch Grad, Shijiazhuang, Hebei, Peoples R China.
   [Fu, Yidian; Lv, Peiyuan] Hebei Gen Hosp, Dept Neurol, Shijiazhuang, Hebei, Peoples R China.
   [Jiang, Chao] Hebei Gen Hosp, Dept Psychosomat Med, Shijiazhuang, Hebei, Peoples R China.
   [Li, Zonglin] Liaocheng Hosp Tradit Chinese Med, Dept Med Lab, Liaocheng, Shandong, Peoples R China.
   [Shi, Xiangyun] Sichuan Normal Univ, Coll Geog & Resources, Chengdu, Peoples R China.
   [Zhang, Jingbo] Chongqing Med Univ, Affiliated Hosp 1, Dept Dermatol, Chongqing, Peoples R China.
C3 Hebei Medical University; Sichuan Normal University; Chongqing Medical
   University
RP Lv, PY (corresponding author), Hebei Med Univ, Sch Grad, Shijiazhuang, Hebei, Peoples R China.; Lv, PY (corresponding author), Hebei Gen Hosp, Dept Neurol, Shijiazhuang, Hebei, Peoples R China.; Zhang, JB (corresponding author), Chongqing Med Univ, Affiliated Hosp 1, Dept Dermatol, Chongqing, Peoples R China.
EM peiyuanlu2@163.com; 49554556samael@gmail.com
RI Zhang, Jingbo/MGU-0032-2025
OI Zhang, Jingbo/0000-0002-9426-209X
FU Scientific and Technological Innovation 2030-Major Project Subject of
   "Brain Science and Brain-inspired Research" [2021ZD0201807]; Hebei
   Natural Science Foundation [H2022307075]; The 2023 Government-Funded
   Program for Outstanding Clinical Medical Talents in Hebei Province
   [ZF2023177]
FX The author(s) declare financial support was received for the research,
   authorship, and/or publication of this article. This study was supported
   by grants from the Scientific and Technological Innovation 2030-Major
   Project Subject of "Brain Science and Brain-inspired Research" (Grant
   No. 2021ZD0201807), Hebei Natural Science Foundation (H2022307075), and
   the 2023 Government-Funded Program for Outstanding Clinical Medical
   Talents in Hebei Province (Grant No. ZF2023177). The funders had no role
   in the design and conduct of the study; collection, management,
   analysis, and interpretation of the data; preparation, review, or
   approval of the manuscript; and decision to submit the manuscript for
   publication.
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   Young AJ, 2001, ARCH BIOCHEM BIOPHYS, V385, P20, DOI 10.1006/abbi.2000.2149
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   Yu YC, 2022, INT J CANCER, V150, P1599, DOI 10.1002/ijc.33925
   Zeng QM, 2020, BIOMED PHARMACOTHER, V131, DOI 10.1016/j.biopha.2020.110792
   Zhang KW, 2023, FOOD FUNCT, V14, P836, DOI [10.1039/d2fo02204d, 10.1039/D2FO02204D]
NR 76
TC 0
Z9 0
U1 3
U2 3
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD JAN 23
PY 2025
VL 12
AR 1473487
DI 10.3389/fnut.2025.1473487
PG 13
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA U9L7V
UT WOS:001414926500001
PM 39917746
OA gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Soltero, EG
   Solovey, AN
   Hebbel, RP
   Palzer, EF
   Ryder, JR
   Shaibi, GQ
   Olson, M
   Fox, CK
   Rudser, KD
   Dengel, DR
   Evanoff, NG
   Kelly, AS
AF Soltero, Erica G.
   Solovey, Anna N.
   Hebbel, Robert P.
   Palzer, Elise F.
   Ryder, Justin R.
   Shaibi, Gabriel Q.
   Olson, Micah
   Fox, Claudia K.
   Rudser, Kyle D.
   Dengel, Donald R.
   Evanoff, Nicholas G.
   Kelly, Aaron S.
TI Relationship of Circulating Endothelial Cells With Obesity and
   Cardiometabolic Risk Factors in Children and Adolescents
SO JOURNAL OF THE AMERICAN HEART ASSOCIATION
LA English
DT Article
DE adolescents; cardiovascular risk; children; endothelial health; novel
   biomarkers; obesity
ID PULSE-WAVE VELOCITY; CARDIOVASCULAR-DISEASE; OVERWEIGHT CHILDREN;
   MICROPARTICLES; DYSFUNCTION; PREVALENCE; CHILDHOOD; INSULIN; STRESS;
   TISSUE
AB Background
   Circulating endothelial cells (CECs) reflect early changes in endothelial health; however, the degree to which CEC number and activation is related to adiposity and cardiovascular risk factors in youth is not well described.
   Methods and Results
   Youth in this study (N=271; aged 8-20 years) were classified into normal weight (body mass index [BMI] percentage <85th; n=114), obesity (BMI percentage >= 95th to <120% of the 95th; n=63), and severe obesity (BMI percentage >= 120% of the 95th; n=94) catagories. CEC enumeration was determined using immunohistochemical examination of buffy coat smears and activated CEC (percentage of vascular cell adhesion molecule-1 expression) was assessed using immunofluorescent staining. Cardiovascular risk factors included measures of body composition, blood pressure, glucose, insulin, lipid profile, C-reactive protein, leptin, adiponectin, oxidized low-density lipoprotein cholesterol, carotid artery intima-media thickness, and pulse wave velocity. Linear regression models examined associations between CEC number and activation with BMI and cardiovascular risk factors. CEC number did not differ among BMI classes (P>0.05). Youth with severe obesity had a higher degree of CEC activation compared with normal weight youth (8.3%; 95% CI, 1.1-15.6 [P=0.024]). Higher CEC number was associated with greater body fat percentage (0.02 per percentage; 95% CI, 0.00-0.03 [P=0.020]) and systolic blood pressure percentile (0.01 per percentage; 95% CI, 0.00-0.01 [P=0.035]). Higher degree of CEC activation was associated with greater visceral adipose tissue (5.7% per kg; 95% CI, 0.4-10.9 [P=0.034]) and non-high-density lipoprotein cholesterol (0.11% per mg/dL; 95% CI, 0.01-0.21 [P=0.039]).
   Conclusions
   Methods of CEC quantification are associated with adiposity and cardiometabolic risk factors and may potentially reflect accelerated atherosclerosis as early as childhood.
C1 [Soltero, Erica G.] Baylor Coll Med, Dept Pediat, Childrens Nutr Res Ctr, 1100 Bates Ave, Houston, TX 77030 USA.
   [Solovey, Anna N.; Hebbel, Robert P.] Univ Minnesota, Sch Med, Div Hematol Oncol & Transplantat, Minneapolis, MN 55455 USA.
   [Hebbel, Robert P.] Univ Minnesota, Sch Med, Dept Med, Minneapolis, MN 55455 USA.
   [Palzer, Elise F.; Rudser, Kyle D.] Univ Minnesota, Sch Publ Hlth, Div Biostat, Minneapolis, MN 55455 USA.
   [Ryder, Justin R.; Fox, Claudia K.; Rudser, Kyle D.; Dengel, Donald R.; Evanoff, Nicholas G.; Kelly, Aaron S.] Univ Minnesota, Sch Med, Ctr Pediat Obes Med, Minneapolis, MN 55455 USA.
   [Ryder, Justin R.; Fox, Claudia K.; Rudser, Kyle D.; Kelly, Aaron S.] Univ Minnesota, Sch Med, Dept Pediat, Minneapolis, MN 55455 USA.
   [Shaibi, Gabriel Q.; Olson, Micah] Arizona State Univ, Ctr Hlth Promot & Dis Prevent, Phoenix, AZ USA.
   [Shaibi, Gabriel Q.; Olson, Micah] Phoenix Childrens Hosp, Dept Pediat Endocrinol & Diabet, Phoenix, AZ USA.
   [Dengel, Donald R.; Evanoff, Nicholas G.] Univ Minnesota, Sch Kinesiol, Minneapolis, MN USA.
C3 Baylor College of Medicine; University of Minnesota System; University
   of Minnesota Twin Cities; University of Minnesota System; University of
   Minnesota Twin Cities; University of Minnesota System; University of
   Minnesota Twin Cities; University of Minnesota System; University of
   Minnesota Twin Cities; University of Minnesota System; University of
   Minnesota Twin Cities; Arizona State University; Arizona State
   University-Downtown Phoenix; Phoenix Children's Hospital; University of
   Minnesota System; University of Minnesota Twin Cities
RP Soltero, EG (corresponding author), Baylor Coll Med, Dept Pediat, Childrens Nutr Res Ctr, 1100 Bates Ave, Houston, TX 77030 USA.
EM soltero@bcm.edu
RI Soltero, Erica/GNP-7555-2022
OI Soltero, Erica/0000-0002-7202-9262; Ryder, Justin/0000-0002-7506-9497;
   Shaibi, Gabriel/0000-0002-6890-2903
FU National Heart, Lung, and Blood Institute of the National Institutes of
   Health (NIH) [R01 HL110957]; National Institutes of Diabetes and
   Digestive and Kidney Diseases of the NIH [R01 DK10757901]; American
   Heart Association [18POST33990036]; US Department of
   Agriculture/Agricultural Research Service (USDA/ARS) [58-3092-5-001];
   American Heart Association (AHA) [18POST33990036] Funding Source:
   American Heart Association (AHA)
FX This work was supported by the National Heart, Lung, and Blood Institute
   of the National Institutes of Health (NIH) R01 HL110957 (principal
   investigator: Kelly). This work was also supported in part by the
   National Institutes of Diabetes and Digestive and Kidney Diseases of the
   NIH R01 DK10757901 (principal investigator: Shaibi) and a postdoctoral
   fellowship awarded by the American Heart Association 18POST33990036
   (principal investigator: Soltero). Dr Soltero is also supported by a US
   Department of Agriculture/Agricultural Research Service (USDA/ARS)
   cooperative agreement #58-3092-5-001.
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NR 44
TC 9
Z9 9
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
EI 2047-9980
J9 J AM HEART ASSOC
JI J. Am. Heart Assoc.
PD JAN 5
PY 2021
VL 10
IS 1
AR e018092
DI 10.1161/JAHA.120.018092
PG 8
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA PR2QX
UT WOS:000607087000020
PM 33372524
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Simpson, L
   McArdle, N
   Eastwood, PR
   Ward, KL
   Cooper, MN
   Wilson, AC
   Hillman, DR
   Palmer, LJ
   Mukherjee, S
AF Simpson, Laila
   McArdle, Nigel
   Eastwood, Peter R.
   Ward, Kim L.
   Cooper, Matthew N.
   Wilson, Annette C.
   Hillman, David R.
   Palmer, Lyle J.
   Mukherjee, Sutapa
TI Physical Inactivity Is Associated with Moderate-Severe Obstructive Sleep
   Apnea
SO JOURNAL OF CLINICAL SLEEP MEDICINE
LA English
DT Article
DE weight; sleep disordered breathing; cardio metabolic; occupation;
   exercise
ID RISK-FACTORS; EXERCISE; EPIDEMIOLOGY; RESISTANCE; MUSCLES
AB Study Objectives: To investigate whether low levels of physical activity were associated with an increased occurrence of obstructive sleep apnea (OSA), OSA-related symptoms, and cardiometabolic risk.
   Methods: A case-control study design was used. OSA cases were patients referred to a sleep clinic for suspected OSA (n = 2,340). Controls comprised participants from the Busselton community (n = 1,931). Exercise and occupational activity were derived from questionnaire data. Associations were modelled using logistic and linear regression and adjusted for confounders.
   Results: In comparison with moderate exercise, the high, low, and nil exercise groups had an odds ratio (OR) for moderate-severe OSA of 0.6 (95% CI 0.5-0.8), 1.6 (95% CI 1.2-2.0), and 2.7 (95% CI 1.9-3.7), respectively. Relative to men in heavy activity occupations, men in medium, light and sedentary occupations had an OR for moderate-severe OSA of 1.7 (95% CI 1.1-2.5), 2.1 (95% CI 1.4-3.2), and 1.8 (95% CI 1.2-2.8), respectively. Relative to women in medium activity occupations, women in light and sedentary occupations had an OR for moderate-severe OSA of 4.2 (95% CI 2.6-7.2) and 3.5 (2.0-6.0). OSA patients who adequately exercised had lower: levels of doctor-diagnosed depression (p = 0.047); symptoms of fatigue (p < 0.0001); systolic (p = 0.015) and diastolic blood pressure (p = 0.015); and C-reactive protein (CRP) (p = 0.003).
   Conclusions: Low levels of physical activity were associated with moderate-severe OSA. Exercise in individuals with OSA is associated with lower levels of depression, fatigue, blood pressure and CRP.
C1 [Simpson, Laila; Ward, Kim L.] Univ Western Australia, Ctr Genet Origins Hlth & Dis, Perth, WA 6009, Australia.
   [Simpson, Laila; Eastwood, Peter R.; Hillman, David R.] Univ Western Australia, Fac Sci, Sch Anat Physiol & Human Biol, Ctr Sleep Sci, Perth, WA 6009, Australia.
   [Simpson, Laila; McArdle, Nigel; Eastwood, Peter R.; Ward, Kim L.; Wilson, Annette C.; Hillman, David R.; Mukherjee, Sutapa] Queen Elizabeth Med Ctr II, Western Australian Sleep Disorders Res Inst, Perth, WA, Australia.
   [McArdle, Nigel; Eastwood, Peter R.; Ward, Kim L.; Hillman, David R.] Sir Charles Gairdner Hosp, Dept Pulm Physiol & Sleep Med, Needlands, WA, Australia.
   [McArdle, Nigel] Univ Western Australia, Sch Med & Pharmacol, Perth, WA 6009, Australia.
   [Ward, Kim L.] Univ Western Australia, Sch Populat Hlth, Perth, WA 6009, Australia.
   [Cooper, Matthew N.] Univ Western Australia, Telethon Kids Inst, Perth, WA 6009, Australia.
   [Wilson, Annette C.] Univ Western Australia, Sch Math & Stat, Perth, WA 6009, Australia.
   [Palmer, Lyle J.] Univ Adelaide, Joanna Briggs Inst, Adelaide, SA, Australia.
   [Palmer, Lyle J.] Univ Adelaide, Sch Translat Hlth Sci, Adelaide, SA, Australia.
   [Mukherjee, Sutapa] Adelaide Inst Sleep Hlth, Adelaide, SA, Australia.
C3 University of Western Australia; University of Western Australia; Sir
   Charles Gairdner Hospital; University of Western Australia; University
   of Western Australia; University of Western Australia; The Kids Research
   Institute Australia; University of Western Australia; University of
   Adelaide; University of Adelaide; Flinders University South Australia;
   Adelaide Institute for Sleep Health
RP Simpson, L (corresponding author), Univ Western Australia, Ctr Sleep Sci, 14-16 Pkwy, Crawley, WA 6009, Australia.
EM laila.simpson@uwa.edu.au
RI Ward, Kim/X-9856-2019; Eastwood, Peter/H-9129-2014; Palmer, Lyle
   John/K-3196-2014; Simpson, Laila/O-7281-2014; Eastwood,
   Peter/JPY-3383-2023; Mukherjee, Sutapa/U-7262-2017; Cooper,
   Matthew/J-4420-2014
OI Palmer, Lyle John/0000-0002-1628-3055; Simpson,
   Laila/0000-0001-7189-4791; Eastwood, Peter/0000-0002-4490-4138;
   Mukherjee, Sutapa/0000-0001-5021-1648; Hillman,
   David/0000-0001-9987-539X; Cooper, Matthew/0000-0003-1139-3682
FU ResMed; Sir Charles Gairdner Hospital Research Foundation; Hollywood
   Private Hospital Research Foundation; Australian Postgraduate Award;
   Australian National Health and Medical Research Council Senior Research
   Fellowship [1042341]
FX This was not an industry supported study. Dr. McArdle has received
   research support from ResMed. Dr. Hillman has received research support
   from and is on the speakers' bureau for ResMed. The other authors have
   indicated no financial conflicts of interest. The West Australian Sleep
   Health Study was supported by Sir Charles Gairdner Hospital Research
   Foundation and the Hollywood Private Hospital Research Foundation. Dr.
   Simpson was supported by an Australian Postgraduate Award. Prof.
   Eastwood was supported by an Australian National Health and Medical
   Research Council Senior Research Fellowship (No. 1042341).
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NR 40
TC 45
Z9 47
U1 0
U2 8
PU AMER ACAD SLEEP MEDICINE
PI DARIEN
PA 2510 N FRONTAGE RD, DARIEN, IL 60561 USA
SN 1550-9389
EI 1550-9397
J9 J CLIN SLEEP MED
JI J. Clin. Sleep Med.
PY 2015
VL 11
IS 10
BP 1091
EP 1100
AR PII jc-00456-14
DI 10.5664/jcsm.5078
PG 10
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA CY3FO
UT WOS:000366294100005
PM 26285117
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Chou, AY
   Saw, J
AF Chou, Annie Y.
   Saw, Jacqueline
TI Basis for Sex-Specific Expression of Takotsubo Cardiomyopathy, Cardiac
   Syndrome X, and Spontaneous Coronary Artery Dissection
SO CANADIAN JOURNAL OF CARDIOLOGY
LA English
DT Review
ID APICAL BALLOONING SYNDROME; TERM-FOLLOW-UP; LEFT-VENTRICULAR
   DYSFUNCTION; ISCHEMIA SYNDROME EVALUATION; ACUTE MYOCARDIAL-INFARCTION;
   ST-SEGMENT ELEVATION; C-REACTIVE PROTEIN; FIBROMUSCULAR DYSPLASIA;
   CLINICAL CHARACTERISTICS; MENTAL STRESS
AB Takotsubo cardiomyopathy, cardiac syndrome X, and spontaneous coronary artery dissection are cardiovascular syndromes with a predilection for women. A complex interplay between neurohormonal factors, genetic influences, anatomic alterations, and other factors together affect cardiovascular function. Specifically, a high, variable, or deficient estrogen state leads to vasomotor instability with propensity toward vasoconstriction and endothelial dysfunction that predispose women to myocardial impairment, microvascular dysfunction, and coronary arterial wall instability. As the predominant sex hormone in women, fluctuating estrogen levels lead to a sex disparity in the expression of these cardiac entities. This review explores the research on sex-based differences of the neurohormonal, genetic, and mechanical factors in the normal cardiovascular, system and in the pathophysiology of these 3 conditions. The understanding of their prevalence, pathogenesis, and sex disparity allows improved recognition, management, and support of female patients inflicted with these syndromes.
C1 [Chou, Annie Y.; Saw, Jacqueline] Univ British Columbia, Vancouver Gen Hosp, Div Cardiol, Vancouver, BC V5Z 1M9, Canada.
C3 University of British Columbia
RP Saw, J (corresponding author), Vancouver Gen Hosp, 2775 Laurel St,Level 9, Vancouver, BC V5Z 1M9, Canada.
EM jsaw@mail.ubc.ca
FU AstraZeneca; Abbott Vascular; St Jude Medical for SCAD research
FX Dr Saw has received unrestricted research grants from AstraZeneca,
   Abbott Vascular, and St Jude Medical for SCAD research. Dr Chous has no
   conflicts of interest to disclose.
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NR 91
TC 14
Z9 15
U1 0
U2 6
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0828-282X
EI 1916-7075
J9 CAN J CARDIOL
JI Can. J. Cardiol.
PD JUL
PY 2014
VL 30
IS 7
BP 738
EP 746
DI 10.1016/j.cjca.2013.12.008
PG 9
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA AM6NG
UT WOS:000339981300007
PM 24656530
DA 2025-06-11
ER

PT J
AU Bakhtiari, A
   Hajian-Tilaki, K
   Omidvar, S
   Nasiri-Amiri, F
AF Bakhtiari, Afsaneh
   Hajian-Tilaki, Karimollah
   Omidvar, Shabnam
   Nasiri-Amiri, Fatemeh
TI Clinical and metabolic response to soy administration in older women
   with metabolic syndrome: a randomized controlled trial
SO DIABETOLOGY & METABOLIC SYNDROME
LA English
DT Article
DE Metabolic syndrome; Elderly women; Soy protein; Soy-nut
ID PLACEBO-CONTROLLED-TRIAL; OXIDATIVE STRESS; DOUBLE-BLIND; RISK-FACTORS;
   LIPID-LEVELS; BLOOD-PRESSURE; PROTEIN-INTAKE; WEIGHT-LOSS;
   POSTMENOPAUSAL WOMEN; INSULIN SENSITIVITY
AB BackgroundThere are many studies on the health effects of soy, only a few describe the effects of the simultaneous use of two types of soy on multiple components of metabolic syndrome (MetS). The present study was designed to determine the effects of roasted soy-nut and textured soy protein (TSP) intake on clinical and metabolic status of older women with MetS borderline parameters.MethodThis randomized, single-blind, controlled clinical trial included 75 women60years old with a diagnosis of MetS based on ATP III criteria. The participants were randomly allocated into three groups of 25 people; soy-nut, TSP and control groups for 12week. Fasting blood samples were taken at the beginning and end of the trial to compare the metabolic responses. All participants provided three dietary records and physical activity records during the intervention. We used the Kolmogorov-Smirnov, ANOVA, ANCOVA, paired-t test, and the Generalized Linear Model (GLM) repeated measures analysis.ResultsDietary intake and physical activity of the participants in two groups were not significantly different. After 12weeks of intervention the participants who received soy-nut had a significant decrease in total cholesterol (TC) (p<0.001), low density lipoprotein, very low density lipoprotein, apolipoprotein B100, fasting blood glucose, insulin (p<0.05), HOMA-IR, malondialdehyde (MDA) (p<0.01) level. Morever, a significant increase in total antioxidant capacity (TAC) (p<0.01) level compared with the control group. At the same time, the TSP brought significant decrease only in TC, insulin, MDA (p<0.05) level and a significant increase in total TAC (p<0.05) level. We did not find any significant effect in intervention groups, on apolipoprotein AI, triglyceride (TG), high density lipoprotein (HDL-C), TG/HDL, C-reactive protein and fibrinogen levels after intervention.ConclusionShort-term intakes of roasted soy-nut and TSP have shown to improve the lipid profiles, markers of glucose intolerance and oxidative stress; although the roasted soy-nut was more effective than TSP. Therefore, a moderate daily intake of roasted soy-nut as snacks or TSP as a meal complement by individuals with borderline parameters of MetS can be a safe and a practical modality to avoid the progression of the disease as well as to limit the side effects of drug intake.Trial registration MUBABOL.REC.1388.1
C1 [Bakhtiari, Afsaneh] Babol Univ Med Sci, Hlth Res Inst, Mobil Impairment Res Ctr, Babol Sar, Iran.
   [Hajian-Tilaki, Karimollah] Babol Univ Med Sci, Dept Biostat & Epidemiol, Fac Med, Babol Sar, Iran.
   [Omidvar, Shabnam] Babol Univ Med Sci, Hlth Res Inst, Social Determinants Hlth Res Ctr, Babol Sar, Iran.
   [Nasiri-Amiri, Fatemeh] Babol Univ Med Sci, Hlth Res Inst, Infertil & Hlth Reprod Res Ctr, Babol Sar, Iran.
   [Bakhtiari, Afsaneh; Omidvar, Shabnam; Nasiri-Amiri, Fatemeh] Babol Univ Med Sci, Fac Nursing & Midwifery, Dept Midwifery, Babol Sar, Iran.
C3 Babol University of Medical Sciences; Babol University of Medical
   Sciences; Babol University of Medical Sciences; Babol University of
   Medical Sciences; Babol University of Medical Sciences
RP Nasiri-Amiri, F (corresponding author), Babol Univ Med Sci, Hlth Res Inst, Infertil & Hlth Reprod Res Ctr, Babol Sar, Iran.
EM nasiri_fa@yahoo.com
RI Hajian-tilaki, Karimollah/A-4339-2017; omidvar, shabnam/ABB-6164-2021;
   Bakhtiari, Afsaneh/E-6390-2018; Nasiriamiri, Fatemeh/I-2047-2016
OI Nasiriamiri, Fatemeh/0000-0001-6794-7627; Hajian,
   Karimollah/0000-0001-6830-1916; Bakhtiari, Afsaneh/0000-0002-4732-6900
FU Babol University of Medical Sciences [229]
FX This study was approved and funded by the Deputy for Research of Babol
   University of Medical Sciences (Grant No: 229).
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NR 69
TC 16
Z9 16
U1 1
U2 5
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1758-5996
J9 DIABETOL METAB SYNDR
JI Diabetol. Metab. Syndr.
PD JUN 20
PY 2019
VL 11
AR 47
DI 10.1186/s13098-019-0441-y
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA IE6MP
UT WOS:000472490600001
PM 31249633
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Stanton, R
   Rosenbaum, S
   Lederman, O
   Happell, B
AF Stanton, Robert
   Rosenbaum, Simon
   Lederman, Oscar
   Happell, Brenda
TI Implementation in action: how Australian Exercise Physiologists approach
   exercise prescription for people with mental illness
SO JOURNAL OF MENTAL HEALTH
LA English
DT Article
DE implementation; exercise; mental illness; physiologist; training
ID PHYSICAL-ACTIVITY INTERVENTIONS; INTERNATIONAL-ORGANIZATION;
   CARDIOMETABOLIC RISK; HEALTH-PROFESSIONALS; NATIONAL-SURVEY; NURSES
   WORKING; DISORDERS; SCHIZOPHRENIA; METAANALYSIS; DEPRESSION
AB Background: Accredited Exercise Physiologists (AEPs) are trained to deliver exercise and physical activity interventions for people with chronic and complex health conditions including those with mental illness. However, their views on exercise for mental illness, their exercise prescription practices, and need for further training are unknown.Aims: To examine the way in which Australian AEPs prescribe exercise for people with mental illness.Methods: Eighty-one AEPs (33.310.4 years) completed an online version of the Exercise in Mental Illness Questionnaire. Findings are reported using descriptive statistics.Results: AEPs report a high level of knowledge and confidence in prescribing exercise for people with mental illness. AEPs rate exercise to be at least of equal value to many established treatments for mental illness, and frequently prescribe exercise based on current best-practice principles. A need for additional training was identified. The response rate was low (2.4%) making generalisations from the findings difficult.Conclusions: Exercise prescription practices utilised by AEPs are consistent with current best-practice guidelines and there is frequent consultation with consumers to individualise exercise based on their preferences and available resources. Further training is deemed important.
C1 [Stanton, Robert] Cent Queensland Univ, Sch Hlth Med & Appl Sci, Rockhampton, Qld 4702, Australia.
   [Rosenbaum, Simon] Univ New South Wales, Sch Psychiat, Sydney, NSW, Australia.
   [Rosenbaum, Simon] Univ New South Wales, Black Dog Inst, Sydney, NSW, Australia.
   [Lederman, Oscar] Univ New South Wales, Sch Med Sci, Sydney, NSW, Australia.
   [Happell, Brenda] Univ Canberra, Fac Hlth, ACT Hlth, SYNERGY,Nursing & Midwifery Res Ctr, Woden, ACT, Australia.
C3 Central Queensland University; University of New South Wales Sydney;
   Black Dog Institute; University of New South Wales Sydney; University of
   New South Wales Sydney; University of Canberra; ACT Health Australia
RP Stanton, R (corresponding author), Cent Queensland Univ, Sch Hlth Med & Appl Sci, Rockhampton, Qld 4702, Australia.
EM r.stanton@cqu.edu.au
RI Stanton, Rob/AAJ-5157-2020; Rosenbaum, Simon/Y-3241-2019; Happell,
   Brenda/HSI-0570-2023
OI Rosenbaum, Simon/0000-0002-8984-4941; Happell,
   Brenda/0000-0002-7293-6583; Lederman, Oscar/0000-0002-0321-5723
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NR 60
TC 22
Z9 23
U1 1
U2 16
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 0963-8237
EI 1360-0567
J9 J MENT HEALTH
JI J. Ment. Heal.
PY 2018
VL 27
IS 2
BP 150
EP 156
DI 10.1080/09638237.2017.1340627
PG 7
WC Psychology, Clinical; Psychiatry
WE Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA FX5GT
UT WOS:000426106800009
PM 28645230
DA 2025-06-11
ER

PT J
AU Wuyt, AK
   Nguelefack-Mbuyo, EP
   Fofié, CK
   Nguelefack, TB
AF Wuyt, Adeline K.
   Nguelefack-Mbuyo, Elvine P.
   Fofie, Christian K.
   Nguelefack, Telesphore B.
TI The methanol extract of Ceiba pentandra reverses monosodium
   glutamate-induced cardiometabolic syndrome in rats via the regulation of
   dyslipidemia, inflammation, oxidative stress, and insulin sensitization
SO HELIYON
LA English
DT Article
DE Cardiometabolic syndrome; Ceiba pentandra; Cytokines; Insulin
   sensitivity; Obesity; Oxidative stress
ID RESISTANCE; GLUCOSE; OBESITY
AB The antidiabetic effects of the methanol extract of the stem bark of Ceiba pentandra (Cp) have been demonstrated in various experimental models. Besides, this extract is rich in 8-formyl-7-hydroxy-5-isopropyl-2-methoxy-3-methyl-1,4-naphthaquinone, 2,4,6-Trimethoxyphenol and vavain. However, it remains unknown whether Cp can mitigate cardiometabolic syndrome (CMS). The present study assessed the curative properties of Cp against Monosodium Glutamate (MSG)-induced CMS in rats. Male neonate Wistar rats were intraperitoneally administered with MSG (4 mg/g/day) during the first 5 days of life (postnatal days 2-6). They were kept under standard breeding conditions up to 5 months of age for the development of CMS. Diseased animals were then orally treated with atorvastatin (80 mg/kg/d) or Cp (75 and 150 mg/kg/day) for 28 days during which food intake, body mass, blood pressure, heart rate, glucose, and insulin tolerance were monitored. Plasma and tissues were collected on day 29th to assess the lipid profile, oxidative stress, and inflammatory parameters. The histomorphology of the adipose tissue was also evaluated. Cp significantly (p < 0.001) reduced the obesogenic and lipid profiles, adipocyte size, blood pressure, and oxidative and inflammatory status in MSG-treated rats. Cp also ameliorated glucose (p < 0.05) and insulin sensitivities (p < 0.001) hence, reducing animals' cardiometabolic risk score (p < 0.001). The curative effect of Cp on cardiometabolic syndrome is related to its capacity to reduce oxidative stress, inflammation, dyslipidemia, and increase insulin sensitivity. These results demonstrate the potential of Cp as a good candidate for alternative treatment of CMS.
C1 [Wuyt, Adeline K.; Nguelefack-Mbuyo, Elvine P.; Fofie, Christian K.; Nguelefack, Telesphore B.] Univ Dschang, Fac Sci, Res Unit Anim Physiol & Phytopharmacol, Dschang, Cameroon.
C3 Universite de Dschang
RP Nguelefack, TB (corresponding author), Univ Dschang, Fac Sci, Res Unit Anim Physiol & Phytopharmacol, Dschang, Cameroon.
EM adeline.wuyt@yahoo.fr; mbuyopamielvine@gmail.com;
   christian.fofie@gmail.com; telesphore.nguelefack@univ-dschang.org
RI ; Nguelefack-Mbuyo, Elvine Pami/AAT-5689-2021
OI Nguelefack, Telesphore Benoit/0000-0002-5006-6927; Fofie Kuete,
   Christian/0000-0001-6148-7578; Nguelefack-Mbuyo, Elvine
   Pami/0000-0002-5754-7686
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NR 51
TC 1
Z9 1
U1 1
U2 6
PU CELL PRESS
PI CAMBRIDGE
PA 50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA
EI 2405-8440
J9 HELIYON
JI Heliyon
PD FEB
PY 2023
VL 9
IS 2
AR e13689
DI 10.1016/j.heliyon.2023.e13689
EA FEB 2023
PG 16
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA D4PG8
UT WOS:000968561900001
PM 36865446
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Manning, JJ
   Green, HM
   Glass, M
   Finlay, DB
AF Manning, Jamie J.
   Green, Hayley M.
   Glass, Michelle
   Finlay, David B.
TI Pharmacological selection of cannabinoid receptor effectors: Signalling,
   allosteric modulation and bias
SO NEUROPHARMACOLOGY
LA English
DT Review
DE Cannabinoid receptor; Allosteric modulation; Biased agonism; Signal
   transduction; Functional selectivity; G protein coupled receptor
ID PROTEIN-COUPLED RECEPTORS; MU-OPIOID RECEPTOR; AGONIST-INDUCED
   INTERNALIZATION; CARDIOMETABOLIC RISK-FACTORS; CB1 RECEPTOR; FUNCTIONAL
   SELECTIVITY; LIGAND BIAS; BETA-ARRESTIN; IN-VITRO; OVERWEIGHT PATIENTS
AB The type-1 cannabinoid receptor (CB1) is a promising drug target for a wide range of diseases. However, many existing and novel candidate ligands for CB1 have shown only limited therapeutic potential. Indeed, no ligands are currently approved for the clinic except formulations of the phytocannabinoids Delta 9-THC and CBD and a small number of analogues. A key limitation of many promising CB1 ligands are their on-target adverse effects, notably including psychoactivity (agonists) and depression/suicidal ideation (inverse agonists). Recent drug development attempts have therefore focussed on altering CB1 signalling profiles in two ways. Firstly, with compounds that enhance or reduce the signalling of endogenous (endo-) cannabinoids, namely allosteric modulators. Secondly, with compounds that probe the capability of selectively targeting specific cellular signalling pathways that may mediate therapeutic effects using biased ligands. This review will summarise the current paradigm of CB1 signalling in terms of the intracellular transduction pathways acted on by the receptor. The development of compounds that selectively activate CB1 signalling pathways, whether allosterically or via orthosteric agonist bias, will also be addressed.
C1 [Manning, Jamie J.; Green, Hayley M.; Glass, Michelle; Finlay, David B.] Univ Otago, Dept Pharmacol & Toxicol, POB 56, Dunedin 9054, New Zealand.
C3 University of Otago
RP Finlay, DB (corresponding author), Univ Otago, Dept Pharmacol & Toxicol, POB 56, Dunedin 9054, New Zealand.
EM david.finlay@otago.ac.nz
RI Manning, Jamie/KUD-2794-2024; Glass, Michelle/AAE-7799-2019
OI Manning, Jamie J./0000-0002-6945-2254; Green,
   Hayley/0000-0001-6533-4632; Glass, Michelle/0000-0002-5997-6898
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NR 180
TC 19
Z9 20
U1 0
U2 16
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0028-3908
EI 1873-7064
J9 NEUROPHARMACOLOGY
JI Neuropharmacology
PD AUG 1
PY 2021
VL 193
AR 108611
DI 10.1016/j.neuropharm.2021.108611
EA MAY 2021
PG 14
WC Neurosciences; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pharmacology & Pharmacy
GA SR7FF
UT WOS:000661206400004
PM 34000272
DA 2025-06-11
ER

PT J
AU Andersson, P
   Linge, J
   Gurholt, TP
   Sonderby, IE
   Hindley, G
   Andreassen, OA
   Leinhard, OD
AF Andersson, Patrik
   Linge, Jennifer
   Gurholt, Tiril P.
   Sonderby, Ida E.
   Hindley, Guy
   Andreassen, Ole A.
   Leinhard, Olof Dahlqvist
TI Poor muscle health and cardiometabolic risks associated with
   antidepressant treatment
SO OBESITY
LA English
DT Article
ID SUBCUTANEOUS ADIPOSE-TISSUE; PRIMARY-CARE; DEPRESSION; OBESITY; CANADA;
   PEOPLE
AB Objective: This study aims to investigate whether antidepressant users display differences in fat distribution and muscle composition relative to non-users and to explore risk factors for developing cardiovascular disease (CVD) and type 2 diabetes. Methods: The study used quantitative adipose and muscle tissue measures derived from magnetic resonance imaging data from UK Biobank (N = 40,174). Fat distribution and muscle composition of selective serotonin reuptake inhibitor (SSRI) and tricyclic antidepressant (TCA) users were compared with sex-, age-, and BMI-matched control individuals. Cox regression models were used to test for increased risk of developing CVD and type 2 diabetes. Results: SSRI users had more visceral fat, smaller muscle volume, and higher muscle fat infiltration compared with matched control individuals. Female users showed a larger increase in BMI over time compared with male users. However, male users displayed an unhealthier body composition profile. Male SSRI users also had an increased risk of developing CVD. Both male and female TCA users showed lower muscle volume and an increased risk of developing type 2 diabetes. Conclusions: Adverse changes in body composition of antidepressant users are not captured by tracking the body weight or the BMI of the patients. These changes may lead to a worsened cardiometabolic risk profile.
C1 [Andersson, Patrik; Linge, Jennifer; Leinhard, Olof Dahlqvist] AMRA Med AB, Badhusgatan 5, S-58222 Linkoping, Sweden.
   [Linge, Jennifer; Leinhard, Olof Dahlqvist] Linkoping Univ, Dept Hlth Med & Caring Sci, Div Diagnost & Specialist Med, Linkoping, Sweden.
   [Gurholt, Tiril P.; Sonderby, Ida E.; Hindley, Guy; Andreassen, Ole A.] Univ Oslo, Oslo Univ Hosp, Norwegian Ctr Mental Disorders Res NORMENT, Div Mental Hlth & Addict, Oslo, Norway.
   [Sonderby, Ida E.] Oslo Univ Hosp, Dept Med Genet, Oslo, Norway.
   [Sonderby, Ida E.] Univ Oslo, KG Jebsen Ctr Neurodev Disorders, Oslo, Norway.
   [Leinhard, Olof Dahlqvist] Linkoping Univ, Ctr Med Image Sci & Visualizat CMIV, Linkoping, Sweden.
C3 Linkoping University; University of Oslo; University of Oslo; University
   of Oslo; Linkoping University
RP Andersson, P (corresponding author), AMRA Med AB, Badhusgatan 5, S-58222 Linkoping, Sweden.
EM patrik.j.andersson@amramedical.com
RI Andreassen, Ole/AAY-7531-2020; Gurholt, Tiril/S-1457-2019; Leinhard,
   Olof/K-4228-2013
OI Gurholt, Tiril/0000-0002-1272-7616; Linge, Jennifer/0000-0001-7399-8375
FU Research Council of Norway [223273]; South-Eastern Norway Regional
   Health Authority [2022080, 2020060]; European Union [847776]
FX The Research Council of Norway (#223273); South-Eastern Norway Regional
   Health Authority (#2022080); and European Union's Horizon2020 Research
   and Innovation Program (CoMorMent project; grant#847776). Ida E. S &
   oslash;nderby is supported by the South-Eastern Norway Regional Health
   Authority (#2020060).
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NR 47
TC 3
Z9 3
U1 0
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1930-7381
EI 1930-739X
J9 OBESITY
JI Obesity
PD OCT
PY 2024
VL 32
IS 10
BP 1857
EP 1869
DI 10.1002/oby.24085
PG 13
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA H3P8W
UT WOS:001322602500014
PM 39315407
DA 2025-06-11
ER

PT J
AU Gaggini, M
   Pingitore, A
   Vassalle, C
AF Gaggini, Melania
   Pingitore, Alessandro
   Vassalle, Cristina
TI Plasma Ceramides Pathophysiology, Measurements, Challenges, and
   Opportunities
SO METABOLITES
LA English
DT Review
DE ceramides; aerobic exercise; cardiometabolic risk and disease;
   lipidomics
ID CORONARY-ARTERY-DISEASE; LONG-CHAIN CERAMIDES; INSULIN SENSITIVITY;
   CARDIOVASCULAR-DISEASE; EXERCISE DURATION; OXIDATIVE STRESS;
   SKELETAL-MUSCLE; LIPID RAFTS; SPHINGOLIPIDS; METABOLISM
AB Ceramides are a family of lipid molecules, composed of sphingosine and a fatty acid, and transported by lipoproteins (primarily by low-density lipoproteins) in the bloodstream. They are not only structural lipids, but multifunctional and bioactive molecules with key roles in many important cellular pathways, such as inflammatory processes and apoptosis, representing potential biomarkers of cardiometabolic diseases as well as pharmacological targets. Recent data reported ceramide modulation by diet and aerobic exercise, suggesting nutrients and exercise-targeting sphingolipid pathways as a countermeasure, also in combination with other therapies, for risk and progression of chronic disease prevention and health maintenance. In this review, we focus on the available data regarding remarks on ceramide structure and metabolism, their pathophysiologic roles, and the effect of dietary habit and aerobic exercise on ceramide levels. Moreover, advancements and limitations of lipidomic techniques and simplification attempts to overcome difficulties of interpretation and to facilitate practical applications, such as the proposal of scores, are also discussed.
C1 [Gaggini, Melania; Pingitore, Alessandro] CNR, Inst Clin Physiol, I-56124 Pisa, Italy.
   [Vassalle, Cristina] FDN CNR Reg Toscana G Monasterio, Via Moruzzi 1, I-56124 Pisa, Italy.
C3 Consiglio Nazionale delle Ricerche (CNR); Istituto di Fisiologia Clinica
   (IFC-CNR)
RP Vassalle, C (corresponding author), FDN CNR Reg Toscana G Monasterio, Via Moruzzi 1, I-56124 Pisa, Italy.
EM mgaggini@ifc.cnr.it; pingi@ifc.cnr.it; cristina.vassalle@ftgm.it
RI Pingitore, Alessandro/K-1843-2018; Gaggini, Melania/C-9379-2017
OI VASSALLE, CRISTINA/0000-0003-3438-6450; Gaggini,
   Melania/0000-0002-6311-502X
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NR 77
TC 31
Z9 32
U1 1
U2 4
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2218-1989
J9 METABOLITES
JI Metabolites
PD NOV
PY 2021
VL 11
IS 11
AR 719
DI 10.3390/metabo11110719
PG 13
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA XH5BC
UT WOS:000725448700001
PM 34822377
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Cao, H
   Li, BX
   Peng, WJ
   Pan, L
   Cui, Z
   Zhao, W
   Zhang, H
   Tang, NJ
   Niu, KJ
   Sun, JX
   Han, XY
   Wang, ZF
   Liu, K
   He, HJ
   Cao, YJ
   Xu, ZY
   Shan, AQ
   Meng, G
   Sun, YY
   Guo, CY
   Liu, XH
   Xie, YY
   Wen, FY
   Shan, GL
   Zhang, L
AF Cao, Han
   Li, Bingxiao
   Peng, Wenjuan
   Pan, Li
   Cui, Ze
   Zhao, Wei
   Zhang, Han
   Tang, Naijun
   Niu, Kaijun
   Sun, Jixin
   Han, Xiaoyan
   Wang, Zhengfang
   Liu, Kuo
   He, Huijing
   Cao, Yajing
   Xu, Zhiyuan
   Shan, Anqi
   Meng, Ge
   Sun, Yanyan
   Guo, Chunyue
   Liu, Xiaohui
   Xie, Yunyi
   Wen, Fuyuan
   Shan, Guangliang
   Zhang, Ling
TI Associations of long-term exposure to ambient air pollution with cardiac
   conduction abnormalities in Chinese adults: The CHCN-BTH cohort study
SO ENVIRONMENT INTERNATIONAL
LA English
DT Article
DE Ambient air pollution; Long-term exposure; Cardiac conduction system
ID RESTING HEART-RATE; ROAD TRAFFIC NOISE; CARDIOVASCULAR-DISEASE;
   OXIDATIVE STRESS; PARTICULATE MATTER; PROGNOSTIC-SIGNIFICANCE; SYSTEMIC
   INFLAMMATION; INTERVAL DURATION; RATE-VARIABILITY; DAILY MORTALITY
AB Background: Evidence regarding the effects of long-term and high-level ambient air pollution exposure on cardiac conduction systems remains sparse.
   Objectives: To investigate the associations of long-term exposure to air pollution and cardiac conduction abnormalities in Chinese adults and explore the susceptibility characteristics.
   Methods: In 2017, a total of 27,047 participants aged 18-80 years were recruited from the baseline survey of the Cohort Study on Chronic Disease of Communities Natural Population in Beijing, Tianjin and Hebei (CHCN-BTH). The three year (2014-2016) average pollutant concentrations were assessed by a spatial statistical model for PM2.5 and air monitoring stations for PM10, SO2, NO2, O-3 and CO. Residential proximity to a roadway was calculated by neighborhood analysis. Associations were estimated by two-level generalized linear mixed models. Stratified analyses related to demographic characteristics, health behaviors, and cardiometabolic risk factors were performed. Two-pollutant models were used to evaluate the possible role of single pollutants.
   Results: We detected significant associations of long-term air pollutant exposure with increased heart rate (HR), QRS and QTc, such that an interquartile range increase in PM2.5 was associated with 3.63% (95% CI: 3.07%, 4.19%), 1.21% (95% CI: 0.83%, 1.60%), and 0.13% (95% CI: 0.07%, 0.18%) changes in HR, QRS and QTc, respectively. Compared to the other pollutants, the estimates of PM2.5 remained the most stable across all twopollutant models. Similarly, significant associations were observed between living closer to a major roadway and higher HR, QRS and QTc. Stratified analyses showed generally greater association estimates in older people, males, smokers, alcohol drinkers, and those with obesity, hypertension and diabetes.
   Conclusions: Long-term exposure to ambient air pollution was associated with cardiac conduction abnormalities in Chinese adults, especially in older people, males, smokers, alcohol drinkers, and those with cardiometabolic risk factors. PM2.5 may be the most stable pollutant to reflect the associations.
C1 [Cao, Han; Li, Bingxiao; Peng, Wenjuan; Liu, Kuo; Sun, Yanyan; Guo, Chunyue; Liu, Xiaohui; Xie, Yunyi; Wen, Fuyuan; Zhang, Ling] Capital Med Univ, Dept Epidemiol & Hlth Stat, Sch Publ Hlth, 10 Xi Toutiao You Anmenwai, Beijing 100069, Peoples R China.
   [Cao, Han; Li, Bingxiao; Peng, Wenjuan; Liu, Kuo; Sun, Yanyan; Guo, Chunyue; Liu, Xiaohui; Xie, Yunyi; Wen, Fuyuan; Zhang, Ling] Beijing Municipal Key Lab Clin Epidemiol, Beijing, Peoples R China.
   [Pan, Li; He, Huijing; Shan, Guangliang] Chinese Acad Med Sci, Dept Epidemiol & Stat, Inst Basic Med Sci, 5 Dongdansantiao, Beijing 100005, Peoples R China.
   [Pan, Li; He, Huijing; Shan, Guangliang] Peking Union Med Coll, Sch Basic Med, 5 Dongdansantiao, Beijing 100005, Peoples R China.
   [Cui, Ze; Sun, Jixin; Cao, Yajing] Hebei Prov Ctr Dis Prevent & Control, Dept Chron & Noncommunicable Dis Prevent & Contro, Shijiazhuang, Hebei, Peoples R China.
   [Zhao, Wei; Han, Xiaoyan; Xu, Zhiyuan] Chaoyang Dist Ctr Dis Prevent & Control, Dept Chron & Noncommunicable Dis Prevent & Contro, Beijing, Peoples R China.
   [Zhang, Han; Wang, Zhengfang] Beijing Aerosp Gen Hosp, Hlth Management Ctr, Beijing, Peoples R China.
   [Tang, Naijun; Shan, Anqi] Tianjin Med Univ, Sch Publ Hlth, Dept Occupat & Environm Hlth, Tianjin, Peoples R China.
   [Niu, Kaijun; Meng, Ge] Tianjin Med Univ, Nutr Epidemiol Inst, Tianjin, Peoples R China.
   [Niu, Kaijun; Meng, Ge] Tianjin Med Univ, Sch Publ Hlth, Tianjin, Peoples R China.
C3 Capital Medical University; Chinese Academy of Medical Sciences - Peking
   Union Medical College; Chinese Academy of Medical Sciences - Peking
   Union Medical College; Peking Union Medical College; Tianjin Medical
   University; Tianjin Medical University; Tianjin Medical University
RP Zhang, L (corresponding author), Capital Med Univ, Dept Epidemiol & Hlth Stat, Sch Publ Hlth, 10 Xi Toutiao You Anmenwai, Beijing 100069, Peoples R China.; Shan, GL (corresponding author), Chinese Acad Med Sci, Dept Epidemiol & Stat, Inst Basic Med Sci, 5 Dongdansantiao, Beijing 100005, Peoples R China.; Shan, GL (corresponding author), Peking Union Med Coll, Sch Basic Med, 5 Dongdansantiao, Beijing 100005, Peoples R China.
EM guangliang_shan@163.com; zlilyepi@ccmu.edu.cn
RI Guo, Chunyue/HIU-0769-2022; He, Huijing/ABB-1408-2021; Niu,
   Kaijun/ADD-6222-2022; Cao, Han/GQH-8175-2022; Wen, Fuyuan/LFU-9256-2024
OI Zhang, Ling/0000-0003-2468-864X; Niu, Kaijun/0000-0002-8772-2481
FU National Key Research and Development Program of China
   [2016YFC0900600/2016YFC0900603]
FX This work was supported by The National Key Research and Development
   Program of China grant number 2016YFC0900600/2016YFC0900603.
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NR 76
TC 24
Z9 26
U1 3
U2 23
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0160-4120
EI 1873-6750
J9 ENVIRON INT
JI Environ. Int.
PD OCT
PY 2020
VL 143
AR 105981
DI 10.1016/j.envint.2020.105981
PG 13
WC Environmental Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology
GA PI8KV
UT WOS:000601333900017
PM 32738766
OA gold
DA 2025-06-11
ER

PT J
AU Kahl, KG
   Hueper, K
   Schweiger, U
   Gutberlet, M
   Detlef, AM
   Weiss, C
   von Bohlen, A
   Pul, R
   Lichtinghagen, R
   Wacker, F
   Hartung, D
AF Kahl, K. G.
   Hueper, K.
   Schweiger, U.
   Gutberlet, M.
   Detlef, A. -M.
   Weiss, C.
   von Bohlen, A.
   Pul, R.
   Lichtinghagen, R.
   Wacker, F.
   Hartung, D.
TI Pericardial, intra-abdominal, and subcutaneous adipose tissue in
   patients with major depressive disorder
SO ACTA PSYCHIATRICA SCANDINAVICA
LA English
DT Article
DE depression; cardio-vascular diseases; diabetes mellitus
ID CORONARY-HEART-DISEASE; VISCERAL ABDOMINAL FAT; CARDIOVASCULAR-DISEASE;
   INTRATHORACIC FAT; EPICARDIAL FAT; RISK-FACTOR; CARDIOMETABOLIC RISK;
   ATHEROSCLEROSIS MESA; COMPUTED-TOMOGRAPHY; ANTIDEPRESSANT USE
AB Objective: Major depressive disorder (MDD) is associated with an increased risk for developing coronary artery disease (CAD). Recently, pericardial adipose tissue, a metabolically active visceral fat depot surrounding the heart, has been implicated in the pathogenesis of CAD. Therefore, we investigated pericardial adipose tissue volumes in patients with MDD and compared them to healthy comparison subjects.
   Method: In this case-control study at a university medical center, 50 male and female in-patients with MDD and 25 healthy men and women were examined. The main outcome measures were the volumes of pericardial adipose tissue, intra-abdominal adipose tissue (IaAT) and subcutaneous adipose tissue (ScAT) which were measured using magnetic resonance imaging.
   Results: The pericardial adipose tissue volumes were greater in men and women with MDD compared with the healthy comparison group following adjustments for the effects of age, weight, height, and physical activity.
   Conclusion: This study expands our knowledge about the alterations in body composition that occur in patients with MDD. The findings are highly relevant for understanding the comorbidity between heart disease and depressive disorders.
C1 [Kahl, K. G.; Detlef, A. -M.; Weiss, C.; von Bohlen, A.] Hannover Med Sch MHH, Dept Psychiat Social Psychiat & Psychotherapy, Hannover, Germany.
   [Hueper, K.; Gutberlet, M.; Wacker, F.; Hartung, D.] MHH, Inst Diagnost & Intervent Radiol, Hannover, Germany.
   [Schweiger, U.] Med Univ Lubeck, Dept Psychiat & Psychotherapy, D-23538 Lubeck, Germany.
   [Pul, R.] MHH, Dept Neurol, Hannover, Germany.
   [Lichtinghagen, R.] MHH, Inst Clin Chem, Hannover, Germany.
C3 Hannover Medical School; Hannover Medical School; University of Lubeck;
   Hannover Medical School; Hannover Medical School
RP Kahl, KG (corresponding author), Hannover Med Sch, Dept Psychiat Social Psychiat & Psychotherapy, Carl Neuberg Str 1, D-30625 Hannover, Germany.
EM kahl.kai@mh-hannover.de
RI Hueper, Katja/J-9566-2016; Gutberlet, Matthias/AAL-2699-2021
OI Pul, Refik/0000-0002-8940-9317
FU Servier
FX Kai G. Kahl received speaker honoraria from Eli Lilly, BMS, Otsuka,
   Servier, Lundbeck, and Janssen-Cilag and a research grant from Servier.
   Ulrich Schweiger received a speaker honorarium from Astra Zeneca.
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NR 45
TC 22
Z9 23
U1 0
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0001-690X
EI 1600-0447
J9 ACTA PSYCHIAT SCAND
JI Acta Psychiatr. Scand.
PD AUG
PY 2014
VL 130
IS 2
BP 137
EP 143
DI 10.1111/acps.12242
PG 7
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA AL9AW
UT WOS:000339432800008
PM 24433292
DA 2025-06-11
ER

PT J
AU Wu, YH
   Chueh, KS
   Chuang, SM
   Long, CY
   Lu, JH
   Juan, YS
AF Wu, Yi-Hsuan
   Chueh, Kuang-Shun
   Chuang, Shu-Mien
   Long, Cheng-Yu
   Lu, Jian-He
   Juan, Yung-Shun
TI Bladder Hyperactivity Induced by Oxidative Stress and Bladder Ischemia:
   A Review of Treatment Strategies with Antioxidants
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE overactive bladder; oxidative stress; bladder dysfunction; antioxidants
ID LOWER URINARY-TRACT; GREEN TEA CATECHINS; MITOCHONDRIAL-MEMBRANE
   DEPOLARIZATION; PARTIAL OUTLET OBSTRUCTION; INDUCED OVERACTIVE BLADDER;
   DETRUSOR OVERACTIVITY; METABOLIC SYNDROME; RAT MODEL; PHYTOTHERAPEUTIC
   AGENT; RECEPTOR EXPRESSION
AB Overactive bladder (OAB) syndrome, including frequency, urgency, nocturia and urgency incontinence, has a significantly negative impact on the quality-of-life scale (QoL) and can cause sufferer withdrawal from social activities. The occurrence of OAB can result from an imbalance between the production of pro-oxidants, such as free radicals and reactive species, and their elimination through protective mechanisms of antioxidant-induced oxidative stress. Several animal models, such as bladder ischemia/reperfusion (I/R), partial bladder outlet obstruction (PBOO) and ovarian hormone deficiency (OHD), have suggested that cyclic I/R during the micturition cycle induces oxidative stress, leading to bladder denervation, bladder afferent pathway sensitization and overexpression of bladder-damaging molecules, and finally resulting in bladder hyperactivity. Based on the results of previous animal experiments, the present review specifically focuses on four issues: (1) oxidative stress and antioxidant defense system; (2) oxidative stress in OAB and biomarkers of OAB; (3) OAB animal model; (4) potential nature/plant antioxidant treatment strategies for urinary dysfunction with OAB. Moreover, we organized the relationships between urinary dysfunction and oxidative stress biomarkers in urine, blood and bladder tissue. Reviewed information also revealed the summary of research findings for the effects of various antioxidants for treatment strategies for OAB.
C1 [Wu, Yi-Hsuan; Chueh, Kuang-Shun; Juan, Yung-Shun] Kaohsiung Med Univ, Grad Inst Clin Med, Coll Med, Kaohsiung 80708, Taiwan.
   [Wu, Yi-Hsuan; Chueh, Kuang-Shun; Chuang, Shu-Mien; Juan, Yung-Shun] Kaohsiung Med Univ, Dept Urol, Coll Med, Kaohsiung 80708, Taiwan.
   [Wu, Yi-Hsuan] Kaohsiung Municipal Hsiaokang Hosp, Dept Urol, Kaohsiung 80661, Taiwan.
   [Chueh, Kuang-Shun; Juan, Yung-Shun] Kaohsiung Municipal Tatung Hosp, Dept Urol, Kaohsiung 80145, Taiwan.
   [Long, Cheng-Yu] Kaohsiung Med Univ Hosp, Dept Obstet & Gynecol, Kaohsiung 80708, Taiwan.
   [Long, Cheng-Yu; Juan, Yung-Shun] Kaohsiung Med Univ, Regenerat Med & Cell Therapy Res Ctr, Kaohsiung 80708, Taiwan.
   [Lu, Jian-He] Natl Pingtung Univ Sci & Technol, Dept Environm Sci & Engn, Coll Engn, Emerging Cpds Res Ctr, Pingtung 91201, Taiwan.
C3 Kaohsiung Medical University; Kaohsiung Medical University; Kaohsiung
   Medical University; Kaohsiung Municipal Siao-Gang Hospital; Kaohsiung
   Medical University; Kaohsiung Municipal Ta-Tung Hospital; Kaohsiung
   Medical University; Kaohsiung Medical University Hospital; Kaohsiung
   Medical University; National Pingtung University Science & Technology
RP Juan, YS (corresponding author), Kaohsiung Med Univ, Grad Inst Clin Med, Coll Med, Kaohsiung 80708, Taiwan.; Juan, YS (corresponding author), Kaohsiung Med Univ, Dept Urol, Coll Med, Kaohsiung 80708, Taiwan.; Juan, YS (corresponding author), Kaohsiung Municipal Tatung Hosp, Dept Urol, Kaohsiung 80145, Taiwan.; Juan, YS (corresponding author), Kaohsiung Med Univ, Regenerat Med & Cell Therapy Res Ctr, Kaohsiung 80708, Taiwan.
EM maivy0314@gmail.com; spacejason69@yahoo.com.tw; u9181002@gmail.com;
   urolong@yahoo.com.tw; toddherpuma@yahoo.com.tw; juanuro@gmail.com
RI 闕, 光瞬/KQU-3018-2024
OI LU, JIAN-HE/0000-0001-9108-7567; Juan, Yung-Shun/0000-0002-0607-9093;
   Wu, Yi Hsuan/0000-0003-2366-8268
FU Ministry of Science and Technology [MOST 105-2314-B-037-043-MY3,
   MOST109-2314-B-037-096]; Kaohsiung Medical University Hospital;
   Municipal Ta-Tung Hospital [KMUH-106-6R60, KMTTH-108-002, KMTTH-108-003]
FX Supported by Ministry of Science and Technology grants MOST
   105-2314-B-037-043-MY3 (Y.-S.J.) and MOST109-2314-B-037-096 (Y.-S.J.);
   Kaohsiung Medical University Hospital and Municipal Ta-Tung Hospital
   grants KMUH-106-6R60 (Y.-S.J.), KMTTH-108-002 (Y.-S.J.), KMTTH-108-003
   (K.-S.C.).
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TC 34
Z9 34
U1 1
U2 15
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD JUN
PY 2021
VL 22
IS 11
AR 6014
DI 10.3390/ijms22116014
PG 20
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA SQ2IP
UT WOS:000660181700001
PM 34199527
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Gao, J
   Lu, Y
   Gokulnath, P
   Vulugundam, G
   Li, GP
   Li, J
   Xiao, JJ
AF Gao, Juan
   Lu, Yi
   Gokulnath, Priyanka
   Vulugundam, Gururaja
   Li, Guoping
   Li, Jin
   Xiao, Junjie
TI Benefits of physical activity on cardiometabolic diseases in obese
   children and adolescents
SO JOURNAL OF TRANSLATIONAL INTERNAL MEDICINE
LA English
DT Review
DE pediatric obesity; cardiometabolic diseases; sedentary behavior;
   lifestyle modification; physical exercise
ID INSULIN-RESISTANCE; CHILDHOOD OBESITY; FATTY LIVER; OXIDATIVE STRESS;
   ADIPOSE-TISSUE; RISK-FACTORS; EXERCISE; HYPERINSULINEMIA; YOUNG;
   METABOLISM
AB In the past few decades, obesity in the pediatric population has dramatically increased and is common in many countries. Childhood obesity often causes health problems and increases the risk of cardiometabolic diseases such as type 2 diabetes, nonalcohol fatty liver, and cardiovascular diseases. Obesity in young people has been closely associated with environmental, behavioral, and genetic defects, including the availability of high-energy and sugary food and beverages, sedentary behavior, and hereditary factors. Few drugs are currently available to treat obesity in children and adolescents because it is difficult to demonstrate the safety of these drugs on the growth and development of the youth. Lifestyle modifications, such as diet control and physical exercise, are the primary approaches for preventing and treating childhood obesity. Among them, physical activity is a crucial component. This review summarizes the epidemiology, cardiometabolic risk of obesity, therapeutic strategies, and the benefits of exercise on obesity-related chronic diseases in children and adolescents.
C1 [Gao, Juan; Lu, Yi; Xiao, Junjie] Shanghai Univ, Sch Med, Peoples Hosp Nantong 6, Affiliated Nantong Hosp,Inst Geriat, 881 Yonghe Rd, Nantong 226011, Jiangsu, Peoples R China.
   [Gao, Juan; Li, Jin; Xiao, Junjie] Shanghai Univ, Sch Life Sci, Shanghai Engn Res Ctr Organ Repair, Cardiac Regenerat & Ageing Lab,Inst Cardiovasc Sc, Shanghai 200444, Peoples R China.
   [Gokulnath, Priyanka; Li, Guoping] Massachusetts Gen Hosp, Cardiovasc Div, Boston, MA 02114 USA.
   [Gokulnath, Priyanka; Li, Guoping] Harvard Med Sch, Boston, MA 02114 USA.
   [Vulugundam, Gururaja] Natl Res Council Italy, Inst Biochem & Cellular Biol, I-80131 Naples, Italy.
C3 Shanghai University; Shanghai University; Harvard University; Harvard
   University Medical Affiliates; Massachusetts General Hospital; Harvard
   University; Harvard Medical School; Consiglio Nazionale delle Ricerche
   (CNR)
RP Xiao, JJ (corresponding author), Shanghai Univ, Sch Med, Peoples Hosp Nantong 6, Affiliated Nantong Hosp,Inst Geriat, 881 Yonghe Rd, Nantong 226011, Jiangsu, Peoples R China.
EM Junjiexiao@shu.edu.cn
RI Li, Guoping/AAE-7696-2022; Vulugundam, Gururaja/JUV-3497-2023;
   Gokulnath, Priyanka/AAX-4706-2020
OI Vulugundam, Gururaja/0000-0001-7446-5861; Gokulnath,
   Priyanka/0000-0003-2813-330X
FU National Key R&D Program of China [2020YFA0803800]; National Natural
   Science Foundation of China [82020108002, 81911540486, 82170390];
   Science and Technology Commission of Shanghai Municipality [20DZ2255400,
   21XD1421300, 21ZR1422700]; "Dawn" Program of Shanghai Education
   Commission [19SG34]
FX This work was supported by the National Key R&D Program of China (No.
   2020YFA0803800 to Li J), National Natural Science Foundation of China
   (No. 82020108002 and 81911540486 to Xiao J, No. 82170390 to Gao J), the
   grant from Science and Technology Commission of Shanghai Municipality
   (No. 20DZ2255400 and 21XD1421300 to Xiao J, No. 21ZR1422700 to Gao J),
   and the "Dawn" Program of Shanghai Education Commission (No. 19SG34 to
   Xiao J).
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NR 81
TC 18
Z9 18
U1 4
U2 30
PU SCIENDO
PI WARSAW
PA BOGUMILA ZUGA 32A, WARSAW, MAZOVIA, POLAND
SN 2450-131X
EI 2224-4018
J9 J TRANSL INTERN MED
JI J. TRANSL. INTERN. MED.
PD SEP 30
PY 2022
VL 10
IS 3
BP 236
EP 245
DI 10.2478/jtim-2022-0041
EA SEP 2022
PG 10
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 5D3KG
UT WOS:000862050300001
PM 36776239
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Adam, T
   Schamarek, I
   Springer, EA
   Havel, PJ
   Epel, EE
AF Adam, Tanja
   Schamarek, Imke
   Springer, Elizabeth A.
   Havel, Peter J.
   Epel, Elissa E.
TI Adiponectin and negative mood in healthy premenopausal and
   postmenopausal women
SO HORMONES AND BEHAVIOR
LA English
DT Article
DE Adiposity; Adiponectin; Mood; Stress; Catecholamines
ID PITUITARY-ADRENAL AXIS; DEHYDROEPIANDROSTERONE-SULFATE; METABOLIC
   SYNDROME; INSULIN SENSITIVITY; ADIPOSE-TISSUE; VISCERAL OBESITY; FAT
   DISTRIBUTION; BODY-FAT; STRESS; ASSOCIATION
AB Negative mood and stress are associated with cardiovascular and metabolic disease. There are likely many physiological mechanisms underlying the poor health outcomes. The relationship of psychological states (negative mood, life stress, and stress-responsive hormones) and adiponectin, an adipokine that promotes insulin sensitivity, was investigated in two separate studies. The two groups of participants included 52 healthy, premenopausal women, and 63 postmenopausal women with a range of stress levels. The relationship between adiponectin and psychological state (perceived stress and negative mood) was examined cross-sectionally in both groups of participants, but also prospectively (1 year later) in the group of postmenopausal women.
   In premenopausal women, negative mood and nocturnal urinary epinephrine were significantly related to adiponectin, independent of BMI. In postmenopausal women, negative mood was not associated with adiponectin cross-sectionally, but negative mood was a significant predictor for lower levels of adiponectin 1 year later, independent of initial adiponectin concentrations and changes in body mass index. Lastly, having a depressive disorder was related to lower adiponectin. As adiponectin levels are associated with insulin resistance, obesity, and diabetes mellitus, these findings suggest there may be an adiponectin-mediated pathway explaining in part how negative mood affects metabolic health. Mechanistic studies are needed to explore this potential relationship further. (C) 2010 Published by Elsevier Inc.
C1 [Schamarek, Imke; Springer, Elizabeth A.; Epel, Elissa E.] Univ Calif San Francisco, Dept Psychiat, San Francisco, CA 94143 USA.
   [Adam, Tanja] Univ So Calif, Dept Prevent Med, Los Angeles, CA 90033 USA.
   [Havel, Peter J.] Univ Calif Davis, Dept Nutr, Davis, CA 95616 USA.
C3 University of California System; University of California San Francisco;
   University of Southern California; University of California System;
   University of California Davis
RP Epel, EE (corresponding author), Univ Calif San Francisco, Dept Psychiat, 3333 Calif St,Suite 465, San Francisco, CA 94143 USA.
EM eepel@lppi.ucsf
RI Epel, Elissa/ABI-6703-2022; Havel, Peter/AFU-9329-2022
OI Havel, Peter/0000-0003-3652-8301
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NR 48
TC 12
Z9 13
U1 0
U2 6
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0018-506X
EI 1095-6867
J9 HORM BEHAV
JI Horm. Behav.
PD NOV
PY 2010
VL 58
IS 5
BP 699
EP 704
DI 10.1016/j.yhbeh.2010.05.006
PG 6
WC Behavioral Sciences; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Behavioral Sciences; Endocrinology & Metabolism
GA 687SL
UT WOS:000284798100001
PM 20483360
DA 2025-06-11
ER

PT J
AU Brunner, EJ
   Chandola, T
   Marmot, MG
AF Brunner, Eric J.
   Chandola, Tarani
   Marmot, Michael G.
TI Prospective effect of job strain on general and central obesity in the
   Whitehall II study
SO AMERICAN JOURNAL OF EPIDEMIOLOGY
LA English
DT Article
DE body mass index; employment; obesity; prospective studies; stress
ID CORONARY-HEART-DISEASE; EFFORT-REWARD IMBALANCE; METABOLIC SYNDROME;
   PSYCHOSOCIAL FACTORS; MULTIPLE IMPUTATION; BLOOD-PRESSURE; BODY-WEIGHT;
   US ADULTS; RISK; WORK
AB Positive energy balance is the major cause of obesity, and chronic stress may be a contributory factor. The authors examined cumulative work stress, using the Job Strain Questionnaire on four occasions, as a predictor of obesity in a prospective 19-year study of 6,895 men and 3,413 women (aged 35-55 years) in the Whitehall II cohort in London, United Kingdom (baseline: 1985-1988). A dose-response relation was found between work stress and risk of general obesity (body mass index >= 30 kg/m(2)) and central obesity (waist circumference > 102 cm in men, > 88 cm in women) that was largely independent of covariates. The imputed odds ratios of body mass index obesity for one, two, and three or more reports of work stress adjusted for age, sex, and social position were 1.17, 1.24, and 1.73 (trend p < 0.01), respectively. For waist obesity, the corresponding findings were 1.17, 1.41, and 1.61 (trend p < 0.01). Work stress effect was modestly attenuated after exclusion of obese individuals at baseline and further adjustments for smoking; intakes of dietary fiber, fruits and vegetables, and alcohol; and levels of physical activity during follow-up. This study provides prospective, population-based evidence that chronic work stress predicts general and central obesity.
C1 UCL Royal Free & Univ Coll Med Sch, Sch Med, Dept Epidemiol & Publ Hlth, London WC1E 6BT, England.
C3 University of London; University College London; UCL Medical School
RP Brunner, EJ (corresponding author), UCL Royal Free & Univ Coll Med Sch, Sch Med, Dept Epidemiol & Publ Hlth, 1-19 Torrington Pl, London WC1E 6BT, England.
EM e.brunner@ucl.ac.uk
RI Brunner, Eric/H-2114-2011; Chandola, Tarani/I-3192-2013; Marmot,
   Michael/Y-3920-2019
OI Chandola, Tarani/0000-0002-1864-3413; Marmot,
   Michael/0000-0002-2431-6419; Brunner, Eric/0000-0002-0595-4474
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NR 48
TC 266
Z9 322
U1 2
U2 37
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0002-9262
EI 1476-6256
J9 AM J EPIDEMIOL
JI Am. J. Epidemiol.
PD APR 1
PY 2007
VL 165
IS 7
BP 828
EP 837
DI 10.1093/aje/kwk058
PG 10
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA 146UG
UT WOS:000244959600013
PM 17244635
OA Bronze
DA 2025-06-11
ER

PT J
AU Dimina, L
   Tremblay-Franco, M
   Deveaux, A
   Tardivel, C
   Fouillet, H
   Polakof, S
   Martin, JC
   Mariotti, F
AF Dimina, Laurianne
   Tremblay-Franco, Marie
   Deveaux, Ambre
   Tardivel, Catherine
   Fouillet, Helene
   Polakof, Sergio
   Martin, Jean-Charles
   Mariotti, Francois
TI Plasma Metabolome Analysis Suggests That L-Arginine Supplementation
   Affects Microbial Activity Resulting in a Decrease in Trimethylamine
   N-oxide-A Randomized Controlled Trial in Healthy Overweight Adults with
   Cardiometabolic Risk Factors
SO CURRENT DEVELOPMENTS IN NUTRITION
LA English
DT Article
DE TMAO; trigonelline; L-arg supplementation; LC/MS metabolomics; LIMM-PCA
ID NITRIC-OXIDE; GUT MICROBIOTA; METHYL BALANCE; DISEASE
AB Background: The effects of supplementation with L-arginine (L-arg), the precursor of nitric oxide (NO), on vascular and cardiometabolic health have largely been explored. Whether other mechanisms of the action of L-arg exist remains unknown, as arginine metabolism is complicated.Objective: We aimed to characterize the effect of low dose L-arg supplementation on overall human metabolism both in a fasting state and in response to an allostatic stress.Methods: In a randomized, double-blind, crossover study, 32 healthy overweight adults (mean age 45 y) with cardiometabolic risk (fasting plasma triglycerides >150 mg/dL; waist circumference >94 cm [male] or >80 cm [female]) were treated with 1.5 g sustained-release L-arg 3 times/d (4.5 g/d) or placebo for 4 wk. On the last day of treatment, volunteers consumed a high-fat meal challenge (900 kcal, 80% as fat, 13% as carbohydrate, and 7% as protein). Plasma was collected at fasting, 2, 4, and 6 h after the challenge, and the metabolome was analyzed by high-resolution liquid chromatography-mass spectrometry. Metabolic profiles were analyzed using linear mixed models-principal component analysis.Results: The challenge meal explained most of the changes in the metabolome. The overall effect of L-arg supplementation significantly explained 0.5% of the total variance, irrespective of the response to the challenge meal (P < 0.05). Among the metabolites that explain most of the L-arg effect, we found many amino acids, including branched-chain amino acids, that were decreased by L-arg supplementation. L-arg also decreased trimethylamine N-oxide (TMAO). Other changes suggest that L-arg increased methyl demand.Conclusions: Analysis of the effect of 4 wk of L-arg supplementation on the metabolome reveals important effects on methyl balance and gut microbiota activity, such as a decrease in TMAO. Further studies are needed to investigate those mechanisms and the implications of these changes for long-term health.
C1 [Dimina, Laurianne; Deveaux, Ambre; Tardivel, Catherine; Fouillet, Helene; Mariotti, Francois] Univ Paris Saclay, AgroParisTech, INRAE, UMR PNCA, Palaiseau, France.
   [Tremblay-Franco, Marie] Paul Sabatier Univ, Toulouse Univ, Toxalim Res Ctr Food Toxicol, ENVT,INP Purpan,INRAE UMR 1331, Toulouse, France.
   [Tremblay-Franco, Marie] Natl Infrastruct Metabol & Flux, Metatoul AXIOM Platform, MetaboHUB, Toxalim,INRAE UMR 1331, Toulouse, France.
   [Tardivel, Catherine] Aix Marseille Univ, C2VN, INRAE, INSERM, Marseille, France.
   [Polakof, Sergio] Univ Clermont Auvergne, Unite Nutr Humaine, INRAE, UMR 1019, Clermont Ferrand, France.
C3 Universite Paris Saclay; INRAE; AgroParisTech; Universite de Toulouse;
   Universite Toulouse III - Paul Sabatier; Universite Federale Toulouse
   Midi-Pyrenees (ComUE); Ecole Nationale Veterinaire de Toulouse; INRAE;
   Universite de Toulouse; Universite Toulouse III - Paul Sabatier;
   Universite Federale Toulouse Midi-Pyrenees (ComUE); Institut National
   Polytechnique de Toulouse; INRAE; Aix-Marseille Universite; Institut
   National de la Sante et de la Recherche Medicale (Inserm); INRAE; INRAE;
   Universite Clermont Auvergne (UCA)
RP Mariotti, F (corresponding author), Univ Paris Saclay, AgroParisTech, INRAE, UMR PNCA, Palaiseau, France.
EM francois.mariotti@agroparistech.fr
RI Fouillet, Helene/K-7314-2012; Mariotti, Francois/F-9651-2017
OI Mariotti, Francois/0000-0002-4516-3853
FU Pierre Fabre Research Institute
FX Supported by a grant from Pierre Fabre Research Institute. The funder
   had no role in the analysis and interpretation of the results.
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NR 62
TC 2
Z9 2
U1 0
U2 5
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 2475-2991
J9 CURR DEV NUTR
JI Curr. Dev. Nutr.
PD DEC
PY 2023
VL 7
IS 12
AR 102038
DI 10.1016/j.cdnut.2023.102038
EA DEC 2023
PG 11
WC Nutrition & Dietetics
WE Emerging Sources Citation Index (ESCI)
SC Nutrition & Dietetics
GA DZ7O9
UT WOS:001135987000001
PM 38162999
OA Green Published, Green Accepted, gold
DA 2025-06-11
ER

PT J
AU Peluso, I
   Villano, DV
   Roberts, SA
   Cesqui, E
   Raguzzini, A
   Borges, G
   Crozier, A
   Catasta, G
   Toti, E
   Serafini, M
AF Peluso, Ilaria
   Villano, Debora V.
   Roberts, Susan A.
   Cesqui, Eleonora
   Raguzzini, Anna
   Borges, Gina
   Crozier, Alan
   Catasta, Giovina
   Toti, Elisabetta
   Serafini, Mauro
TI Consumption of Mixed Fruit-juice Drink and Vitamin C Reduces
   Postprandial Stress Induced by a High Fat Meal in Healthy Overweight
   Subjects
SO CURRENT PHARMACEUTICAL DESIGN
LA English
DT Article
DE Fruit-juice drink; vitamin C; triglycerides; inflammation; human;
   postprandial stress
ID LOW-GRADE INFLAMMATION; NECROSIS-FACTOR-ALPHA; KAPPA-B ACTIVATION;
   INTESTINAL PERMEABILITY; LIPID-PEROXIDATION; METABOLIC SYNDROME;
   OXIDATIVE STRESS; ACUTE INGESTION; GREEN TEA; PLASMA
AB Postprandial stress induced by acute consumption of meals with a high fat content results in an increase of markers of cardio-metabolic risk. Repeated acute dietary stress may induce a persistent low-grade inflammation, playing a role in the pathogenesis of functional gut diseases. This may cause an impairment of the complex immune response of the gastrointestinal mucosa, which results in a breakdown of oral tolerance. We investigated the effect of ingestion of a fruit-juice drink (FJD) composed by multiple fruit juice and extracts, green tea extracts and vitamin C on postprandial stress induced by a High Fat Meal (HFM) in healthy overweight subjects. Following a double blind, placebo controlled, cross-over design, 15 healthy overweight subjects were randomized to a HFM providing 1334 Kcal (55% fat, 30% carbohydrates and 15% proteins) in combination with 500 mL of a placebo drink (HFM-P) or a fruit-juice drink (HFM-FJD). Ingestion of HFM-P led to an increase in circulating levels of cholesterol, triglycerides, glucose, insulin, TNF-alpha and IL-6. Ingestion of HFM-FJD significantly reduced plasma levels of cholesterol and triglycerides, decreasing inflammatory response mediated by TNF-alpha and IL-6. Ingestion of a fruit-juice drink reduce markers of postprandial stress induced by a HFM.
C1 [Peluso, Ilaria; Villano, Debora V.; Cesqui, Eleonora; Raguzzini, Anna; Catasta, Giovina; Toti, Elisabetta; Serafini, Mauro] Ex Natl Inst Food & Nutr Res INRAN, Agr Res Council CRA, Rome, Italy.
   [Villano, Debora V.] IRCCS San Raffaele La Pisana, Food & Nutr Unit, Rome, Italy.
   [Roberts, Susan A.] Coca Cola Co, Global Sci & Regulatory Affairs, Atlanta, GA USA.
   [Borges, Gina; Crozier, Alan] Univ Glasgow, Sch Med, Glasgow, Lanark, Scotland.
C3 Consiglio per la Ricerca in Agricoltura e L'analisi Dell'economia
   Agraria (CREA); IRCCS San Raffaele Pisana; The Coca-Cola Company;
   University of Glasgow
RP Serafini, M (corresponding author), CRA Ex INRAN, Via Ardeatina 546, I-00178 Rome, Italy.
EM serafini_mauro@yahoo.it
RI Peluso, Ilaria/ABE-3399-2021; Catasta, Giovina/HWQ-3541-2023; Borges,
   Gina/M-2273-2013; Villano Valencia, Debora/F-1022-2012; Serafini,
   Mauro/K-6498-2018; Crozier, Alan/H-6642-2017; Peluso, Ilaria/A-8023-2018
OI Villano Valencia, Debora/0000-0002-8162-8857; Serafini,
   Mauro/0000-0003-0913-936X; Toti, Elisabetta/0000-0003-3798-7745;
   Raguzzini, Anna/0000-0003-4021-6829; Crozier, Alan/0000-0001-7581-6782;
   Peluso, Ilaria/0000-0002-6210-5241
FU Coca-Cola Company
FX Authors declare to have received Funding and Research support from The
   Coca-Cola Company.
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NR 40
TC 37
Z9 42
U1 0
U2 32
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1381-6128
EI 1873-4286
J9 CURR PHARM DESIGN
JI Curr. Pharm. Design
PD FEB
PY 2014
VL 20
IS 6
BP 1020
EP 1024
DI 10.2174/138161282006140220144802
PG 5
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA AE9EF
UT WOS:000334306800022
PM 23701571
DA 2025-06-11
ER

PT J
AU Saraf-Bank, S
   Ahmadi, A
   Paknahad, Z
   Maracy, M
   Nourian, M
AF Saraf-Bank, Sahar
   Ahmadi, Alireza
   Paknahad, Zamzam
   Maracy, Mohammadreza
   Nourian, Mojgan
TI Effects of curcumin supplementation on markers of inflammation and
   oxidative stress among healthy overweight and obese girl adolescents: A
   randomized placebo-controlled clinical trial
SO PHYTOTHERAPY RESEARCH
LA English
DT Article
DE chemerin; curcumin; inflammation; oxidative stress
ID FATTY LIVER-DISEASE; PHARMACOLOGICAL RESEARCH; METABOLIC SYNDROME;
   CHILDHOOD; CHILDREN; BIOAVAILABILITY; ANTIOXIDANT; CHEMERIN
AB Introduction It is well known that there is a strong linkage between obesity, systemic low-grade inflammation, and oxidative stress in the pediatric population. Possible strategies that might control obesity and its relevant problems in this crucial group are of utmost importance. Therefore, the aim of this study was to evaluate the effects of curcumin supplements on inflammation, oxidative stress, and chemerin levels in adolescent girls. Methods Totally, 60 overweight and obese adolescent girls were randomly assigned to either placebo or intervention group in a randomized placebo-controlled parallel trial design. Adolescents consumed one 500-mg curcumin or placebo per day along with a slight weight loss diet for 10 weeks. High-sensitive C-reactive protein (hs-CRP), interleukin 6 (IL-6), total antioxidant capacity (TAC), malondialdehyde (MDA), chemerin levels, and anthropometric measurements were assessed at the beginning and end of the trial. Results Curcumin supplementation had a significant effect on IL-6 levels and oxidative stress markers including TAC and MDA in crude model. After controlling the effects of confounders, curcumin supplementation had a substantial effect on inflammation (hs-CRP and IL-6) and oxidative stress (TAC) marker of adolescents. Discussion Ten weeks of curcumin supplementation had beneficial effects on inflammation and oxidative stress markers among postpubescent overweight and obese girl adolescents.
C1 [Saraf-Bank, Sahar; Nourian, Mojgan] Isfahan Univ Med Sci, Food Secur Res Ctr, Esfahan, Iran.
   [Saraf-Bank, Sahar; Nourian, Mojgan] Isfahan Univ Med Sci, Dept Community Nutr, Sch Nutr & Food Sci, Esfahan, Iran.
   [Ahmadi, Alireza] Isfahan Univ Med Sci, Pediat Cardiovasc Res Ctr, Cardiovasc Res Inst, Esfahan, Iran.
   [Paknahad, Zamzam] Isfahan Univ Med Sci, Dept Clin Nutr, Sch Nutr & Food Sci, Esfahan, Iran.
   [Maracy, Mohammadreza] Isfahan Univ Med Sci, Sch Hlth, Dept Epidemiol & Biostat, Esfahan, Iran.
C3 Isfahan University of Medical Sciences; Isfahan University of Medical
   Sciences; Isfahan University of Medical Sciences; Isfahan University of
   Medical Sciences; Isfahan University of Medical Sciences
RP Nourian, M (corresponding author), Isfahan Univ Med Sci, Dept Community Nutr, Sch Nutr & Food Sci, Esfahan, Iran.
EM nourian@hlth.mui.ac.ir
RI Saraf-Bank, Sahar/W-6232-2019; ahmadi, alireza/C-9535-2018; paknahad,
   zamzam/E-6191-2012
OI paknahad, zamzam/0000-0002-1864-2576
FU Isfahan University of Medical Sciences, Isfahan, Iran [396160] Funding
   Source: Medline
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NR 41
TC 57
Z9 59
U1 1
U2 19
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0951-418X
EI 1099-1573
J9 PHYTOTHER RES
JI Phytother. Res.
PD AUG
PY 2019
VL 33
IS 8
BP 2015
EP 2022
DI 10.1002/ptr.6370
PG 8
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA IM6JS
UT WOS:000478099800007
PM 31206225
DA 2025-06-11
ER

PT J
AU Rius, B
   Duran-Güell, M
   Flores-Costa, R
   López-Vicario, C
   Lopategi, A
   Alcaraz-Quiles, J
   Casulleras, M
   Lozano, JJ
   Titos, E
   Clària, J
AF Rius, Bibiana
   Duran-Guell, Marta
   Flores-Costa, Roger
   Lopez-Vicario, Cristina
   Lopategi, Aritz
   Alcaraz-Quiles, Jose
   Casulleras, Mireia
   Jose Lozano, Juan
   Titos, Esther
   Claria, Joan
TI The specialized proresolving lipid mediator maresin 1 protects
   hepatocytes from lipotoxic and hypoxia-induced endoplasmic reticulum
   stress
SO FASEB JOURNAL
LA English
DT Article
DE NAFLD; UPR; miRNA; liver cells
ID FATTY LIVER; CELL-DEATH; ER STRESS; ACUTE-INFLAMMATION; ADIPOSE-TISSUE;
   RESOLVIN D1; RESOLUTION; DISEASE; ROLES; AUTOPHAGY
AB Endoplasmic reticulum(ER) stress and activation of the unfolded protein response (UPR) are hallmarks of nonalcoholic fatty liver disease (NAFLD), which is the hepatic manifestation of the metabolic syndrome associated with obesity. The specialized proresolving lipid mediator maresin 1 (MaR1) preserves tissue homeostasis by exerting cytoprotective actions, dampening inflammation, and expediting its timely resolution. Here, we explored whether MaR1 protects liver cells from lipotoxic and hypoxia-induced ER stress. Mice were rendered obese by high fat diet feeding, and experiments were performed in primary hepatocytes, Kupffer cells, and precision-cut liver slices (PCLSs). Palmitate-induced lipotoxicity increased ER stress and altered autophagy in hepatocytes, effects that were prevented by MaR1. MaR1 protected hepatocytes against lipotoxicity-induced apoptosis by activating the UPR prosurvival mechanisms and preventing the excessive up-regulation of proapoptotic pathways. Protective MaR1 effects were also seen in hepatocytes challenged with hypoxia and TNF-alpha-induced cell death. High-throughput microRNA (miRNA) sequencing revealed that MaR1 actions were associated with specific miRNA signatures targeting both protein folding and apoptosis. MaR1 also prevented lipotoxic-triggered ER stress and hypoxia-induced inflammation in PCLSs and enhanced Kupffer cell phagocytic capacity. Together, these findings describe the ability of MaR1 to oppose ER stress in liver cells under conditions frequently encountered in NAFLD.
C1 [Rius, Bibiana; Duran-Guell, Marta; Flores-Costa, Roger; Lopez-Vicario, Cristina; Lopategi, Aritz; Alcaraz-Quiles, Jose; Casulleras, Mireia; Titos, Esther; Claria, Joan] IDIBAPS, Hosp Clin, Dept Biochem & Mol Genet, Barcelona, Spain.
   [Lopez-Vicario, Cristina; Jose Lozano, Juan; Titos, Esther; Claria, Joan] CIBERehd, Barcelona, Spain.
   [Claria, Joan] European Fdn Study Chron Liver Failure EF CLIF, Barcelona, Spain.
   [Claria, Joan] Univ Barcelona, Dept Biomed Sci, Barcelona, Spain.
C3 University of Barcelona; Hospital Clinic de Barcelona; IDIBAPS; CIBER -
   Centro de Investigacion Biomedica en Red; CIBEREHD; University of
   Barcelona
RP Clària, J (corresponding author), Hosp Clin Barcelona, Dept Biochem & Mol Genet, Villarroel 170, E-08036 Barcelona, Spain.
EM jclaria@clinic.ub.es
RI Lozano, Juan/JNS-1902-2023; Titos, Esther/AAA-5394-2019; Claria,
   Joan/M-7772-2019
OI TITOS, ESTHER/0000-0002-2543-2243; Duran, Marta/0000-0002-3265-395X;
   Lopez-Vicario, Cristina/0000-0002-6609-8501; Lozano, Juan
   Jose/0000-0001-7613-3908; Casulleras, Mireia/0000-0002-2899-5826
FU Spanish Ministerio de Economia y Competitividad (MEC) under European
   Regional Development Funds [SAF15-63674-R, PIE14/00045]; Instituto de
   Salud Carlos III; MEC [BES-2013-063705]; Agaur/BFU (FI-DGR); Marie Curie
   Action
FX The authors thank Ana Isabel Martinez-Puchol [Institut d'Investigacions
   Biomediques, August Pi i Sunyer (IDIBAPS)] for technical assistance.
   This work was supported by grants from the Spanish Ministerio de
   Economia y Competitividad (MEC) (SAF15-63674-R and PIE14/00045) under
   European Regional Development Funds. CIBERehd is funded by the Instituto
   de Salud Carlos III. This study was carried out at the Center Esther
   Koplowitz (IDIBAPs), which is a member of the Centres de Recerca de
   Catalunya (CERCA) Programme/Generalitat de Catalunya. B.R. is a
   recipient of a MEC fellowship (BES-2013-063705). J.A.-Q. is a recipient
   of an Agaur/BFU fellowship (FI-DGR 2015). A.L. was funded by a Marie
   Curie Action. The authors declare no conflicts of interest.
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NR 60
TC 57
Z9 64
U1 0
U2 21
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
EI 1530-6860
J9 FASEB J
JI Faseb J.
PD DEC
PY 2017
VL 31
IS 12
BP 5384
EP +
DI 10.1096/fj.201700394R
PG 25
WC Biochemistry & Molecular Biology; Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA FO2EX
UT WOS:000416588300022
PM 28768719
OA Bronze, Green Submitted
DA 2025-06-11
ER

PT J
AU Hassen, G
   Singh, A
   Belete, G
   Jain, N
   De la Hoz, I
   Camacho-Leon, GP
   Dargie, NK
   Carrera, KG
   Alemu, T
   Jhaveri, S
   Solomon, N
AF Hassen, Gashaw
   Singh, Abhishek
   Belete, Gizeshwork
   Jain, Nidhi
   De la Hoz, Ivonne
   Camacho-Leon, Genesis P.
   Dargie, Nitsuh K.
   Carrera, Keila G.
   Alemu, Tadesse
   Jhaveri, Sharan
   Solomon, Nebiyou
TI Nonalcoholic Fatty Liver Disease: An Emerging Modern-Day Risk Factor for
   Cardiovascular Disease
SO CUREUS JOURNAL OF MEDICAL SCIENCE
LA English
DT Review
DE patient education; lifestyle modification; bariatric surgery; framingham
   risk score (frs); cardiovascular (cv) risk; cardiovascular disease
   (cvd); obesity; metabolic syndrome (mets); type 2 diabetes mellitus
   (t2dm); nonalcoholic fatty liver disease (nafld)
ID LONG-TERM OUTCOMES; BLOOD-PRESSURE; AMERICAN ASSOCIATION;
   INSULIN-RESISTANCE; HEPATIC STEATOSIS; STEATOHEPATITIS; NAFLD; FIBROSIS;
   HISTOPATHOLOGY; PROGRESSION
AB Nonalcoholic fatty liver disease (NAFLD), also named metabolic dysfunction-associated fatty liver disease (MAFLD), is a progressive disease spectrum encompassing simple steatosis, nonalcoholic steatohepatitis (NASH), fibrosis, and cirrhosis. It is a clinically silent disease leading to multiple extra-hepatic complications/comorbidities. It is an independent risk factor for cardiovascular disease (CVD), increasing susceptibility to hypertension, atherosclerosis, arrhythmia, myocardial dysfunction, cardiac valve deformation, and venous thrombosis through putative mechanisms including systemic inflammation, endothelial dysfunction, oxidative stress, insulin resistance, and altered lipid metabolism. Eventually, it increases the CVD prevalence, incident, and fatality, contributing to a huge health care burden. In fact, CVD is becoming the leading cause of mortality among patients with NAFLD. Other cardiometabolic risk factors coexisting with NAFLD may also accelerate the synergistic development of CVD, which warrants assessment targeting hypertension, diabetes mellitus (DM), obesity, and dyslipidemia to be an integral part of NAFLD care. Monitoring metabolic biomarkers (glucose, glycosylated hemoglobin [HbA1c], insulin, lipids, and lipoproteins), cardiovascular (CV) risk scores ( American College of Cardiology/American Heart Association [ACC/AHA] or Framingham), and subclinical atherosclerosis (coronary artery calcification [CAC], carotid intima- media thickness [CIMT], and carotid plaque) are recommended for risk prediction and reduction. There is no universally accepted treatment for NAFLD, and lifestyle changes with weight loss of at least 10% are the mainstay of management. Combination therapy of ezetimibe and statins have a cardioprotective effect and help reduce liver fat.
   Despite being an emerging risk factor for CVD and its rapidly increasing pattern affecting a quarter of the global population, NAFLD remains overlooked and undetected, unlike the other traditional risk factors. Hence, we conducted a comprehensive narrative review to shed more light on the importance of screening CVD in NAFLD patients. PubMed indexed relevant articles published from 2002 to 2022 (20 years) were searched in April 2022 using medical subject headings (MeSH) as "nonalcoholic fatty liver disease" [Mesh] AND "cardiovascular diseases" [Mesh]. Evidence from 40 observational studies, three clinical trials, one case series, 45 narrative reviews, four systematic reviews and meta-analyses, three systematic reviews, and one meta- analysis were summarized on the epidemiologic data, pathophysiologic mechanisms, clinical features, diagnostic modalities, overlapping management, perceived challenges and health literacy regarding the CVD risk attributed to NAFLD.
C1 [Hassen, Gashaw] Univ Maryland, Capital Reg Med Ctr, Internal Med, Largo, MD 20774 USA.
   [Hassen, Gashaw] Addis Ababa Univ, Med, Addis Ababa, Ethiopia.
   [Hassen, Gashaw] Mercy Med Ctr, Progress Care, Baltimore, MD 21202 USA.
   [Hassen, Gashaw] Parma Univ, Med & Surg, Parma, Italy.
   [Singh, Abhishek] St Vincent Hosp, Internal Med, Worcester, MA 01604 USA.
   [Belete, Gizeshwork] St Agnes Hosp, Internal Med, Baltimore, MD USA.
   [Jain, Nidhi] Himalayan Inst Med Sci, Med & Surg, Dehra Dun, Uttarakhand, India.
   [Jain, Nidhi] Brooklyn Canc Care, Hematol & Oncol, Brooklyn, NY USA.
   [Jain, Nidhi] Sir Ganga Ram Hosp, Internal Med, New Delhi, India.
   [De la Hoz, Ivonne] Univ Zulia, Internal Med, Maracaibo, Venezuela.
   [Camacho-Leon, Genesis P.] Larkin Community Hosp, Div Res & Acad Affairs, South Miami, FL USA.
   [Camacho-Leon, Genesis P.] Univ Zulia, Fac Med, Div Estudios Grad, Maracaibo, Venezuela.
   [Dargie, Nitsuh K.] Grand Canyon Univ, Family Med Internal Med, Phoenix, AZ USA.
   [Carrera, Keila G.] Univ Oriente, Gastroenterol, Maturin, Venezuela.
   [Alemu, Tadesse; Solomon, Nebiyou] Addis Ababa Univ, Internal Med, Addis Ababa, Ethiopia.
   [Jhaveri, Sharan] Smt Nathiba Hargovandas Lakhmichand Municipal Med, Internal Med, Ahmadabad, Gujarat, India.
C3 Addis Ababa University; Mercy Medical Center - Maryland; University of
   Parma; Grand Canyon University; Addis Ababa University
RP Hassen, G (corresponding author), Univ Maryland, Capital Reg Med Ctr, Internal Med, Largo, MD 20774 USA.; Hassen, G (corresponding author), Addis Ababa Univ, Med, Addis Ababa, Ethiopia.; Hassen, G (corresponding author), Mercy Med Ctr, Progress Care, Baltimore, MD 21202 USA.; Hassen, G (corresponding author), Parma Univ, Med & Surg, Parma, Italy.
EM dr.gashaw@yahoo.com
RI Bekele, Tadesse/AAN-9330-2021; Jhaveri, Sharan/ADT-8364-2022; Hassen,
   Gashaw/GLR-3484-2022
OI Singh, Abhishek/0000-0003-3984-0560; Hassen, Gashaw/0000-0002-7616-5616;
   Camacho-Leon, Genesis Paola/0000-0003-0744-1872
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NR 108
TC 29
Z9 32
U1 0
U2 7
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
EI 2168-8184
J9 CUREUS J MED SCIENCE
JI Cureus J Med Sci
PD MAY 30
PY 2022
VL 14
IS 5
AR e25495
DI 10.7759/cureus.25495
PG 15
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA 2K0CQ
UT WOS:000816013700017
PM 35783879
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Nankam, PNA
   Nguelefack, TB
   Goedecke, JH
   Blüher, M
AF Nono Nankam, Pamela A.
   Nguelefack, Telesphore B.
   Goedecke, Julia H.
   Blueher, Matthias
TI Contribution of Adipose Tissue Oxidative Stress to Obesity-Associated
   Diabetes Risk and Ethnic Differences: Focus on Women of African Ancestry
SO ANTIOXIDANTS
LA English
DT Review
DE obesity; adipose tissue; oxidative stress; ethnicity; metabolic risks
ID BODY-FAT DISTRIBUTION; MITOCHONDRIAL SUPEROXIDE-PRODUCTION;
   INSULIN-RESISTANCE; REACTIVE OXYGEN; LIPID-PEROXIDATION;
   CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; RACIAL-DIFFERENCES;
   ENDOTHELIAL-CELLS; NAD(P)H OXIDASE
AB Adipose tissue (AT) storage capacity is central in the maintenance of whole-body homeostasis, especially in obesity states. However, sustained nutrients overflow may dysregulate this function resulting in adipocytes hypertrophy, AT hypoxia, inflammation and oxidative stress. Systemic inflammation may also contribute to the disruption of AT redox equilibrium. AT and systemic oxidative stress have been involved in the development of obesity-associated insulin resistance (IR) and type 2 diabetes (T2D) through several mechanisms. Interestingly, fat accumulation, body fat distribution and the degree of how adiposity translates into cardio-metabolic diseases differ between ethnicities. Populations of African ancestry have a higher prevalence of obesity and higher T2D risk than populations of European ancestry, mainly driven by higher rates among African women. Considering the reported ethnic-specific differences in AT distribution and function and higher levels of systemic oxidative stress markers, oxidative stress is a potential contributor to the higher susceptibility for metabolic diseases in African women. This review summarizes existing evidence supporting this hypothesis while acknowledging a lack of data on AT oxidative stress in relation to IR in Africans, and the potential influence of other ethnicity-related modulators (e.g., genetic-environment interplay, socioeconomic factors) for consideration in future studies with different ethnicities.
C1 [Nono Nankam, Pamela A.; Blueher, Matthias] Univ Leipzig, Helmholtz Zentrum Munchen, Helmholtz Inst Metab Obes & Vasc Res HI MAG, D-04103 Leipzig, Germany.
   [Nono Nankam, Pamela A.; Blueher, Matthias] Univ Hosp Leipzig, D-04103 Leipzig, Germany.
   [Nguelefack, Telesphore B.] Univ Dschang, Fac Sci, Lab Anim Physiol & Phytopharmacol, Dschang 96, Cameroon.
   [Goedecke, Julia H.] South African Med Res Council, Noncommunicable Dis Res Unit, ZA-19070 Cape Town, South Africa.
   [Blueher, Matthias] Univ Leipzig, Med Ctr, Rheumatol, Med Dept Endocrinol 3,Nephrol, D-04103 Leipzig, Germany.
C3 Helmholtz Association; Helmholtz-Center Munich - German Research Center
   for Environmental Health; Leipzig University; Leipzig University;
   Universite de Dschang; South African Medical Research Council; Leipzig
   University
RP Nankam, PNA (corresponding author), Univ Leipzig, Helmholtz Zentrum Munchen, Helmholtz Inst Metab Obes & Vasc Res HI MAG, D-04103 Leipzig, Germany.; Nankam, PNA (corresponding author), Univ Hosp Leipzig, D-04103 Leipzig, Germany.
EM Pamela.NonoNankam@helmholtz-muenchen.de;
   Telesphore.Nguelefack@univ-dschang.org; Julia.Goedecke@mrc.ac.za;
   Matthias.Blueher@medizin.uni-leipzig.de
RI Goedecke, Julia/J-8628-2013
OI Goedecke, Julia/0000-0001-6795-4771
FU Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) [CRC
   1052, 209933838]
FX This work was funded by the Deutsche Forschungsgemeinschaft (DFG, German
   Research Foundation) through CRC 1052, project number 209933838,
   subproject B1 to M.B.
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NR 167
TC 26
Z9 26
U1 0
U2 8
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD APR
PY 2021
VL 10
IS 4
AR 622
DI 10.3390/antiox10040622
PG 19
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA RQ9RL
UT WOS:000642748600001
PM 33921645
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Jagan, K
   Priya, CS
   Kalpana, K
   Vidhya, R
   Anuradha, CV
AF Jagan, Kalivarathan
   Priya, Chandrasekaran Sathiya
   Kalpana, Kalaivanan
   Vidhya, Ramachandran
   Anuradha, Carani Venkatraman
TI Apigenin attenuates hippocampal oxidative events, inflammation and
   pathological alterations in rats fed high fat, fructose diet
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Article
DE High calorie diet; Hippocampus; Oxidative stress; Inflammation;
   Apigenin; Sitagliptin
ID NEURONAL DEGENERATION; METABOLIC SYNDROME; BRAIN; PROTECTION; STRESS;
   NEUROINFLAMMATION; TOXICITY; MEMORY; ACID
AB High calorie diet promotes oxidative stress and chronic low grade inflammation that predispose to brain dysfunction and neurodegeneration. Hippocampus region of the brain has been shown to be particularly sensitive to high calorie diet. We hypothesize that apigenin (API), a flavonoid could attenuate hippocampal derangements induced by high fat-high fructose diet (HFFD). In this study, we investigated the effects of API on oxidative stress and inflammation in the hippocampus, and compared with those of sitagliptin (STG), a standard drug with neuroprotective properties. The markers of oxidative stress and inflammation were examined using biochemical assays, western blotting and immunohistochemistry techniques. HFFD-fed rats showed severe pathological alterations and API treatment rescued the hippocampus from the derangements. API significantly improved the antioxidant machinery, reduced ROS levels and prevented the activation of the stress kinases, inhibitor of kappa B kinase beta (IKKb) and c-Jun NH2 terminal kinase (JNK), and the nuclear translocation and activation of nuclear factor kappa B (NF-kappa B). The plasma levels of inflammatory cytokines were also reduced. Our findings suggest that hippocampal derangements triggered by HFFD feeding were effectively curtailed by API. Suppression of oxidative stress, NF-kappa B activation and JNK phosphorylation in the hippocampus are the mechanisms by which API offers neuroprotection in this model. (C) 2017 Elsevier Masson SAS. All rights reserved.
C1 [Jagan, Kalivarathan; Priya, Chandrasekaran Sathiya; Kalpana, Kalaivanan; Vidhya, Ramachandran; Anuradha, Carani Venkatraman] Annamalai Univ, Dept Biochem & Biotechnol, Annamalainagar 608002, Tamil Nadu, India.
C3 Annamalai University
RP Anuradha, CV (corresponding author), Annamalai Univ, Dept Biochem & Biotechnol, Annamalainagar 608002, Tamil Nadu, India.
EM cvaradha@yahoo.com
RI Venkatraman, Anuradha/U-8717-2019; Chandrasekaran, Sathiya
   Priya/H-3718-2018; Kalivarathan, Jagan/H-9600-2018
OI Chandrasekaran, Sathiya Priya/0000-0002-1943-1244; Carani Venkatraman,
   Anuradha/0000-0001-9924-2533; Kalivarathan, Jagan/0000-0001-7108-1029
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NR 32
TC 33
Z9 37
U1 0
U2 16
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD MAY
PY 2017
VL 89
BP 323
EP 331
DI 10.1016/j.biopha.2017.01.162
PG 9
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA EW4JQ
UT WOS:000402468200039
PM 28237914
DA 2025-06-11
ER

PT J
AU Gak, IA
   Radovic, SM
   Dukic, AR
   Janjic, MM
   Stojkov-Mimic, NJ
   Kostic, TS
   Andric, SA
AF Gak, Igor A.
   Radovic, Sava M.
   Dukic, Aleksandra R.
   Janjic, Marija M.
   Stojkov-Mimic, Natasa J.
   Kostic, Tatjana S.
   Andric, Silvana A.
TI Stress triggers mitochondrial biogenesis to preserve steroidogenesis in
   Leydig cells
SO BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
LA English
DT Article
DE Mitochondrial biogenesis; Leydig cells; Stress; Testosterone; PGC1
ID REPEATED IMMOBILIZATION; ALPHA(1)-ADRENERGIC RECEPTORS; INSULIN
   SENSITIVITY; ADAPTIVE RESPONSE; PGC-1-ALPHA; COMPLEX; CHOLESTEROL;
   COACTIVATOR; EXPRESSION; HORMONE
AB Adaptability to stress is a fundamental prerequisite for survival. Mitochondria are a key component of the stress response in all cells. For steroid-hormones-producing cells, including also Leydig cells of testes, the mitochondria are a key control point for the steroid biosynthesis and regulation. However, the mitochondrial biogenesis in steroidogenic cells has never been explored. Here we show that increased mitochondrial biogenesis is the adaptive response of testosterone-producing Leydig cells from stressed rats. All markers of mitochondria(biogenesis together with transcription factors and related kinases are up-regulated in Leydig cells from rats exposed to repeated psychophysical stress. This is followed with increased mitochondria(mass. The expression of PGC1, master regulator of mitochondrial biogenesis and integrator of environmental signals, is stimulated by cAMP-PRKA, cGMP, and beta-adrenergic receptors. Accordingly, stress-triggered mitochondrial biogenesis represents an adaptive mechanism and does not only correlate with but also is an essential for testosterone production, being both events depend on the same regulators. Here we propose that all events induced by acute stress, the most common stress in human society, provoke adaptive response of testosterone-producing Leydig cells and activate PGC1, a protein required to make new mitochondria but also protector against the oxidative damage. Given the importance of mitochondria for steroid hormones production and stress response, as well as the role of steroid hormones in stress response and metabolic syndrome, we anticipate our result to be a starting point for more investigations since stress is a constant factor in life and has become one of the most significant health problems in modem societies. (C) 2015 Elsevier B.V. All rights reserved.
C1 [Gak, Igor A.; Radovic, Sava M.; Dukic, Aleksandra R.; Janjic, Marija M.; Stojkov-Mimic, Natasa J.; Kostic, Tatjana S.; Andric, Silvana A.] Univ Novi Sad, Fac Sci, Dept Biol & Ecol, Reprod Endocrinol & Signaling Grp, Novi Sad 21000, Serbia.
C3 University of Novi Sad
RP Andric, SA (corresponding author), Univ Novi Sad, Fac Sci, Dept Biol & Ecol, Reprod Endocrinol & Signaling Grp, Dositeja Obradovica Sq 2, Novi Sad 21000, Serbia.
EM silvana.andric@dbe.uns.ac.rs
RI Janjic, Marija/GPF-9090-2022; Kostic, Tatjana/H-4038-2012
OI Radovic Pletikosic, Sava/0000-0001-9482-7532; Kostic,
   Tatjana/0000-0003-3440-8998; Andric, Silvana/0000-0002-2908-8136;
   Janjic, Marija/0000-0002-4617-8889
FU Autonomous Province of Vojvodina [970]; Serbian Ministry of Science
   [173057]
FX Supported by the Autonomous Province of Vojvodina grant No. 970 and the
   Serbian Ministry of Science grant No. 173057.
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NR 66
TC 29
Z9 32
U1 0
U2 21
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0167-4889
EI 1879-2596
J9 BBA-MOL CELL RES
JI Biochim. Biophys. Acta-Mol. Cell Res.
PD OCT
PY 2015
VL 1853
IS 10
BP 2217
EP 2227
DI 10.1016/j.bbamcr.2015.05.030
PN A
PG 11
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA CS0TM
UT WOS:000361775100004
PM 26036344
DA 2025-06-11
ER

PT J
AU Bhotla, HK
   Meyyazhagan, A
   Pushparaj, K
   Pappuswamy, M
   Chaudhary, A
   Arumugam, VA
   Balasubramanian, B
   Varman, DR
   Orlacchio, A
   Rengasamy, KRR
AF Bhotla, Haripriya Kuchi
   Meyyazhagan, Arun
   Pushparaj, Karthika
   Pappuswamy, Manikantan
   Chaudhary, Aditi
   Arumugam, Vijaya Anand
   Balasubramanian, Balamuralikrishnan
   Varman, Durairaj Ragu
   Orlacchio, Antonio
   Rengasamy, Kannan R. R.
TI Prevalence of Cardiovascular Diseases in South Asians: Scrutinizing
   Traditional Risk Factors and Newly Recognized Risk Factors Sarcopenia
   and Osteopenia/Osteoporosis
SO CURRENT PROBLEMS IN CARDIOLOGY
LA English
DT Review
ID BODY-MASS INDEX; CORONARY-HEART-DISEASE; MYOCARDIAL-INFARCTION;
   CARDIOMETABOLIC RISK; HYPERTENSION; ASSOCIATIONS; INDIVIDUALS;
   POPULATIONS; CLOPIDOGREL; DEPRESSION
AB One of the primary reasons for complications and death worldwide are cardiovascular diseases (CVDs), with a death toll of approximately 18 million per year. CVDs include cardiomyopathy, hypertension, ischemic heart disease, coronary heart disease, myocardial infarction, heart attack, hearth failure, etc. Over 80% of the CVD mortality is recorded from lower and middle-income countries. Records from the past decade have highlighted the increase of CVDs among the South Asian populations, and the prime purpose of the review is to jot down the reasons for the steep spike in CVDs. Studies analyzing the causative factors for the increase of CVDs in South Asians are still to be verified. Apart from known predisposing and lifestyle factors, other emerging risk factors associated with CVDs, namely the musculoskeletal diseases sarcopenia and osteopenia, should be tracked to tackle research gaps in upcoming analyses. This requires loads of scientific efforts. With proper monitoring, the raising alarm that the CVD burden generates can be reduced. This review discusses the already established signs and recognizes important clues to the emerging etiology of CVDs in the Asian population and prevention measures to keep it at bay.
C1 [Bhotla, Haripriya Kuchi; Meyyazhagan, Arun; Pappuswamy, Manikantan; Chaudhary, Aditi] CHRIST, Dept Life Sci, Bengaluru, Karnataka, India.
   [Pushparaj, Karthika] Avinashilingam Inst Home Sci & Higher Educ Women, Sch Biosci, Dept Zool, Coimbatore, Tamil Nadu, India.
   [Arumugam, Vijaya Anand] Bharathiar Univ, Dept Human Genet & Mol Biol, Coimbatore, Tamil Nadu, India.
   [Balasubramanian, Balamuralikrishnan] Sejong Univ, Coll Life Sci, Dept Food Sci & Biotechnol, Seoul, South Korea.
   [Varman, Durairaj Ragu] Virginia Commonwealth Univ, Sch Med, Dept Pharmacol & Toxicol, Richmond, VA USA.
   [Orlacchio, Antonio] Fdn St Lucia, Ist Ricovero & Cura Carattere Sci IRCCS, Ctr Europeo Ric Cervello CERC, Lab Neurogenet, Rome, Italy.
   [Orlacchio, Antonio] Univ Perugia, Dipartimento Med & Chirurg, Perugia, Italy.
   [Rengasamy, Kannan R. R.] Saveetha Med Coll & Hosp, Saveetha Inst Med & Tech Sci SIMATS, Ctr Global Hlth Res, Lab Nat Prod & Med Chem LNPMC, Chennai, India.
   [Rengasamy, Kannan R. R.] Saveetha Med Coll & Hosp, Saveetha Inst Med & Tech Sci SIMATS, Lab Nat Prod & Med Chem LNPMC, Ctr Global Hlth Res, Chennai 602105, India.
C3 Christ University; Avinashilingam University for Women; Bharathiar
   University; Sejong University; Virginia Commonwealth University; IRCCS
   Santa Lucia; University of Perugia; Saveetha Institute of Medical &
   Technical Science; Saveetha Medical College & Hospital; Saveetha
   Institute of Medical & Technical Science; Saveetha Medical College &
   Hospital
RP Rengasamy, KRR (corresponding author), Saveetha Med Coll & Hosp, Saveetha Inst Med & Tech Sci SIMATS, Lab Nat Prod & Med Chem LNPMC, Ctr Global Hlth Res, Chennai 602105, India.
EM ragupathir.sdc@saveetha.com
RI Balasubramanian, Balamuralikrishnan/K-6132-2019; Anand,
   Vijaya/AAD-6362-2019; Durairaj, Ragu/AAU-7637-2021; Karthika,
   P/ABG-4896-2020; Rengasamy, Kannan RR/AAA-9792-2020; CHAUDHARY,
   ADITI/GWV-5759-2022; Pappuswamy, Dr Manikantan/ABB-1449-2021; Orlacchio,
   Antonio/A-1968-2014
OI Rengasamy, Kannan RR/0000-0001-7205-7389; Pappuswamy, Dr
   Manikantan/0000-0002-6047-3702; Orlacchio, Antonio/0000-0002-2602-3281;
   Chaudhary, Aditi/0009-0003-0433-5799
FU Italian Ministry of Health [RF19.12]; Department of Medicine and Surgery
   of the University of Perugia [Fondo Ricerca di Base] [DSCH_BA-
   SE19_ORLACCHIO, RICERCABASE_2020_ORLACCHIO]
FX This work was supported by the Italian Ministry of Health [Grant no.
   RF19.12 to A.O.] and the Department of Medicine and Surgery of the
   University of Perugia [Fondo Ricerca di Base, Grants no. DSCH_BA-
   SE19_ORLACCHIO and RICERCABASE_2020_ORLACCHIO to A.O] .
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NR 83
TC 3
Z9 3
U1 0
U2 3
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0146-2806
EI 1535-6280
J9 CURR PROB CARDIOLOGY
JI Curr. Probl. Cardiol.
PD JAN
PY 2024
VL 49
IS 1
AR 102071
DI 10.1016/j.cpcardiol.2023.102071
EA SEP 2023
PN B
PG 22
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA W1BQ1
UT WOS:001089053700001
PM 37690535
DA 2025-06-11
ER

PT J
AU Pitts, C
   Millar, SR
   Perry, IJ
   Phillips, CM
AF Pitts, Caroline
   Millar, Sean R.
   Perry, Ivan J.
   Phillips, Catherine M.
TI Relationships between childhood adversity and inflammatory biomarkers in
   adulthood: A cross-sectional analysis of a middle-to older-aged
   population
SO SSM-POPULATION HEALTH
LA English
DT Article
DE Adverse childhood experiences; Inflammatory biomarkers; Cardiovascular
   disease; Household dysfunction
ID LIFE-COURSE APPROACH; BLOOD-PRESSURE; EXPERIENCES; RISK; ASSOCIATION;
   STRESS; ABUSE; EPIDEMIOLOGY; IMPACT; INDEX
AB Background: Exposure to adverse childhood experiences (ACEs) has been linked with increased cardiometabolic risk in adulthood. Low-grade systemic inflammation may underlie this association. Thus far, however, there has been limited investigation of later life inflammatory biomarkers in the context of childhood adversity. Objectives: To assess ACE history, and ACE subcategory, relationships with a broad range of inflammatory biomarkers in middle -to older -aged adults to test the hypothesis that ACE exposure is associated with an unfavourable inflammatory profile in adulthood and determine whether associations vary by ACE subtype and sex. Methods: This study used data from a random sample of 1,839 men and women aged 46-74 years. Participant exposure to ACEs (overall and subtypes including abuse, neglect and household dysfunction) was determined using a validated 10 -item ACE questionnaire. Inflammatory biomarkers (pro -inflammatory cytokines, adipocytokines, acute -phase response proteins, white blood cell counts and their constituents, coagulation factors and glycoprotein acetyl) were measured from participant blood samples. Linear regression analyses examined relationships between ACE history (overall and each subcategory) and inflammatory biomarkers in adulthood, controlling for potential confounders. Sex -stratified and mediation analyses were also conducted. Results: In age and sex -adjusted models, ACE history was significantly associated with higher c -reactive protein (p = 0.027), resistin (p = 0.024), white blood cell count (WBC) (p = 0.034), monocyte (p = 0.044), eosinophil (p = 0.031) and plasminogen activator inhibitor -1 (p = 0.047) concentrations, and lower adiponectin (p = 0.025) levels. Results from stratified analyses indicated sex differences and ACE subtype specific associations, with household dysfunction identified as the main driver of positive ACE associations with WBCs and constituents (all p < 0.05). Mediation analyses suggested that BMI and smoking mediate relationships between ACE exposures and increased inflammation. Conclusions: This study provides evidence that ACE exposure may be associated with more pro -inflammatory and pro -thrombotic profiles in adulthood. Associations differed according to ACE subtype, and sex differences exist, which may influence cardiometabolic risk.
C1 [Pitts, Caroline; Phillips, Catherine M.] Univ Coll Dublin, Sch Publ Hlth Physiotherapy & Sports Sci, Dublin, Ireland.
   [Millar, Sean R.; Perry, Ivan J.] Univ Coll Cork, Sch Publ Hlth, Cork, Ireland.
C3 University College Dublin; University College Cork
RP Phillips, CM (corresponding author), Univ Coll Dublin, Sch Publ Hlth Physiotherapy & Sports Sci, Dublin, Ireland.
EM catherine.phillips@ucd.ie
RI Phillips, Catherine/E-4412-2013
OI Millar, Sean/0000-0003-4453-8446; Phillips,
   Catherine/0000-0003-4916-4463
FU Irish Health Research Board [HRC/2007/13]
FX This work was supported by a research grant from the Irish Health
   Research Board (reference: HRC/2007/13) . The funders had no role in the
   study design, data collection and analysis, decision to publish or
   preparation of the manuscript.
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NR 61
TC 6
Z9 6
U1 0
U2 3
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 2352-8273
J9 SSM-POPUL HLTH
JI SSM-Popul. Health
PD MAR
PY 2024
VL 25
AR 101608
DI 10.1016/j.ssmph.2024.101608
EA JAN 2024
PG 12
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA JC8I4
UT WOS:001171045000001
PM 38261965
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Chrzczanowicz, J
   Gawron-Skarbek, A
   Kostka, J
   Nowak, D
   Drygas, W
   Jegier, A
   Kostka, T
AF Chrzczanowicz, Jacek
   Gawron-Skarbek, Anna
   Kostka, Joanna
   Nowak, Dariusz
   Drygas, Wojciech
   Jegier, Anna
   Kostka, Tomasz
TI Physical Activity and Total Antioxidant Capacity across an Adult
   Lifespan of Men
SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
LA English
DT Article
DE FREE RADICALS; EXERCISE; CARDIOMETABOLIC RISK PROFILE; AGING
ID SYSTEMIC OXIDATIVE STRESS; URIC-ACID; CARDIOVASCULAR-DISEASE; HUMAN
   SERUM; OLDER MEN; EXERCISE; OBESITY; WOMEN; RISK; AGE
AB CHRZCZANOWICZ, J., A. GAWRON-SKARBEK, J. KOSTKA, D. NOWAK, W. DRYGAS, A. JEGIER, and T. KOSTKA. Physical Activity and Total Antioxidant Capacity across an Adult Lifespan of Men. Med. Sci. Sports Exerc., Vol. 44, No. 4, pp. 575-582, 2012. Purpose: The aim of the study was to determine the association between the long-term physical activity (PA) and the total antioxidant capacity (TAC) of blood serum and their association with coexisting risk factors of cardiometabolic diseases in a group of relatively healthy men. Methods: The research was conducted among 422 males age 19.2-89.8 yr, either sedentary or involved in recreational sports activities. Anthropometric measurements, lipid profile, and measurement of glucose and uric acid levels were performed in every man. Current PA, historical PA, and aerobic fitness (physical working capacity) were assessed. TAC was determined with two spectrophotometric methods: the ferric reducing ability of serum (TAC-FRAS) and 2,2-diphenyl-1-picryl-hydrazyl (TAC-DPPH) tests. Results: TAC was not related to the age of the subjects. Higher current and historical PA were associated with a more favorable cardiometabolic risk profile but not TAC. In fact, current PA level was connected with lower values of TAC-FRAS. Values of both TAC-FRAS and TAC-DPPH decreased with an increase of aerobic capacity. Individuals with coexisting anthropometric and biochemical risk factors of cardiovascular diseases and with elevated values of arterial pressure had higher TAC. Values of both TAC-FRAS (r = 0.66) and TAC-DPPH (r = 0.39) were strongly positively correlated with uric acid level. Conclusions: Overweight, obesity, higher blood pressure, unfavorable blood lipid profile, and especially higher uric acid levels are connected with greater TAC of blood serum across an adult man's life. High PA and fitness are associated with a more favorable overall risk profile of cardiovascular and metabolic diseases but are related to lower TAC.
C1 [Chrzczanowicz, Jacek; Gawron-Skarbek, Anna; Kostka, Tomasz] Med Univ Lodz, Dept Geriatr, PL-90647 Lodz, Poland.
   [Chrzczanowicz, Jacek; Gawron-Skarbek, Anna; Drygas, Wojciech; Kostka, Tomasz] Med Univ Lodz, Dept Prevent Med, PL-90647 Lodz, Poland.
   [Chrzczanowicz, Jacek] Copernicus Mem Hosp, Cardiac Rehabil Ctr, Lodz, Poland.
   [Gawron-Skarbek, Anna] Med Univ Lodz, Dept Hyg & Hlth Promot, PL-90647 Lodz, Poland.
   [Kostka, Joanna] Med Univ Lodz, Dept Phys Med, PL-90647 Lodz, Poland.
   [Nowak, Dariusz] Med Univ Lodz, Dept Clin Physiol, PL-90647 Lodz, Poland.
   [Jegier, Anna] Med Univ Lodz, Dept Sports Med, PL-90647 Lodz, Poland.
   [Kostka, Tomasz] Inst Rheumatol, Warsaw, Poland.
C3 Medical University Lodz; Medical University Lodz; Medical University
   Lodz; Medical University Lodz; Medical University Lodz; Medical
   University Lodz
RP Kostka, T (corresponding author), Med Univ Lodz, Dept Geriatr, Pl Hallera 1, PL-90647 Lodz, Poland.
EM TomaszKostka@wp.pl
RI Drygas, Wojciech/GLR-9863-2022; Kostka, Joanna/S-9965-2016;
   Gawron-Skarbek, Anna/G-3486-2014
OI Gawron-Skarbek, Anna/0000-0002-2953-4060; Drygas,
   Wojciech/0000-0002-4351-6459; Nowak, Dariusz/0000-0003-3445-6930;
   Jegier, Anna/0000-0003-4737-2226; Kostka, Tomasz/0000-0003-0437-650X;
   kostka, joanna/0000-0002-6256-1669
FU Ministry of Education and Science [2 P05D 070 30]; State Committee for
   Scientific Research
FX This study was supported by grant 2 P05D 070 30 from the Ministry of
   Education and Science and the State Committee for Scientific Research.
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NR 40
TC 10
Z9 10
U1 0
U2 14
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0195-9131
J9 MED SCI SPORT EXER
JI Med. Sci. Sports Exerc.
PD APR
PY 2012
VL 44
IS 4
BP 575
EP 582
DI 10.1249/MSS.0b013e318238b7f0
PG 8
WC Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Sport Sciences
GA 913SH
UT WOS:000301897200003
PM 21952634
OA Bronze
DA 2025-06-11
ER

PT J
AU Wan, RQ
   Camandola, S
   Mattson, MP
AF Wan, RQ
   Camandola, S
   Mattson, MP
TI Intermittent fasting and dietary supplementation with 2-deoxy-D-glucose
   improve functional and metabolic cardiovascular risk factors in rats
SO FASEB JOURNAL
LA English
DT Article
DE caloric restriction; cardiovascular disease; glucose metabolism; stress
   response
ID CALORIC RESTRICTION; INSULIN-RESISTANCE; BLOOD-PRESSURE;
   FOOD-RESTRICTION; LIFE-SPAN; VOLUNTARY EXERCISE; DIABETES-MELLITUS;
   FISCHER-344 RATS; BRAIN-DAMAGE; BODY-WEIGHT
AB Hypertension and insulin resistance syndrome are risk factors for cardiovascular disease, and it is therefore important to identify interventions that can reduce blood pressure and improve glucose metabolism. We performed experiments aimed at determining whether intermittent fasting (IF) can improve cardiovascular health and also tested the hypothesis that beneficial effects of IF can be mimicked by dietary supplementation with 2-deoxy-D-glucose (2DG) a non-metabolizable glucose analog. Four-month-old male rats were implanted with telemetry probes to allow continuous monitoring of heart rate, blood pressure, physical activity, and body temperature. Rats were then maintained for 6 months on one of three different dietary regimens: ad libitum feeding, IF, or 2DG supplementation. Rats on the IF regimen consumed 30% less food over time and had reduced body weights compared with rats fed ad libitum, whereas rats on the 2DG regimen did not reduce their food intake and maintained their body weight. Heart rate and blood pressure were significantly decreased within 1 month in rats on IF and 2DG diets and were maintained at reduced levels thereafter. Body temperature was significantly decreased in group IF, but not in group 2DG. Levels of serum glucose and insulin were significantly decreased in rats maintained on IF and 2DG-supplemented diets, suggesting that IF and 2DG diets affect insulin sensitivity in a similar manner. Finally, rats in groups IF and 2DG exhibited increased levels of plasma adrenocorticotropin and corticosterone, indicating that these diets induced a stress response. We conclude that reductions in blood pressure, heart rate, and insulin levels, similar to or greater than those obtained with regular physical exercise programs, can be achieved by IF and by dietary supplementation with 2DG by a mechanism involving stress responses.
C1 NIA, Neurosci Lab, Gerontol Res Ctr, Baltimore, MD 21224 USA.
C3 National Institutes of Health (NIH) - USA; NIH National Institute on
   Aging (NIA)
RP Mattson, MP (corresponding author), NIA, Neurosci Lab, Gerontol Res Ctr, GRC 4F01,5600 Nathan Shock Dr, Baltimore, MD 21224 USA.
EM mattsonm@grc.nia.nih.gov
RI Mattson, Mark/F-6038-2012
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NR 45
TC 113
Z9 123
U1 2
U2 14
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
J9 FASEB J
JI Faseb J.
PD APR
PY 2003
VL 17
IS 6
BP 1133
EP +
DI 10.1096/fj.02-0996fje
PG 19
WC Biochemistry & Molecular Biology; Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 673KL
UT WOS:000182580100026
PM 12709404
DA 2025-06-11
ER

PT J
AU Picu, A
   Petcu, L
   Stefan, S
   Mitu, M
   Lixandru, D
   Ionescu-Tîrgoviste, C
   Pircalabioru, GG
   Ciulu-Costinescu, F
   Bubulica, MV
   Chifiriuc, MC
AF Picu, Ariana
   Petcu, Laura
   Stefan, Simona
   Mitu, Manuela
   Lixandru, Daniela
   Ionescu-Tirgoviste, Constantin
   Pircalabioru, Gratiela Gradisteanu
   Ciulu-Costinescu, Felicia
   Bubulica, Maria-Viorica
   Chifiriuc, Mariana Carmen
TI Markers of Oxidative Stress and Antioxidant Defense in Romanian Patients
   with Type 2 Diabetes Mellitus and Obesity
SO MOLECULES
LA English
DT Article
DE oxidative stress; type 2 diabetes mellitus; obesity; reactive oxygen
   species; inflammation
ID HOMEOSTASIS MODEL ASSESSMENT; ADIPONECTIN-LEPTIN RATIO;
   INSULIN-RESISTANCE; CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME;
   PROINSULIN LEVELS; RISK-FACTORS; COMPLICATIONS; GLUCOSE; NEUTROPHILS
AB Type 2 diabetes mellitus (T2DM) is strongly associated with obesity. The adipose tissue secretes bioactive adipokines leading to low grade inflammation, amplified by oxidative stress, which promotes the formation of advanced glycation end products and eventually leads to dyslipidemia and vascular complications. The aim of this study was to correlate anthropometric, biochemical and oxidative stress parameters in newly diagnosed (ND) T2DM patients and to investigate the role of oxidative stress in T2DM associated with obesity. A group of 115 ND-T2DM patients was compared to a group of 32 healthy subjects in terms of clinical, anthropometric, biochemical and oxidative stress parameters. ND-T2DM patients had significantly lower adiponectin, glutathione (GSH) and gluthatione peroxidase (GPx) and elevated insulin, proinsulin, HOMA-IR index, proinsulin/insulin (P/I) and proinsulin/adiponectin (P/A) ratio, fructosamine, and total oxidant status (TOS). The total body fat mass was positively correlated with total oxidant status (TOS). Positive correlations were found between TOS and glycated hemoglobin (HbA1c), and between TOS and glycaemia. Negative correlations were identified between: GPx and glycaemia, GPx and HbA1c, and also between GSH and fructosamine. The total antioxidant status was negatively correlated with the respiratory burst. The identified correlations suggest the existence of a complex interplay between diabetes, obesity and oxidative stress.
C1 [Picu, Ariana; Petcu, Laura; Stefan, Simona; Mitu, Manuela; Ionescu-Tirgoviste, Constantin] NIDNMD Prof NC Paulescu, 2th Dist, Bucharest 020042, Romania.
   [Picu, Ariana; Petcu, Laura; Pircalabioru, Gratiela Gradisteanu; Chifiriuc, Mariana Carmen] Univ Bucharest, Fac Biol, 5th Dist, Bucharest 050095, Romania.
   [Lixandru, Daniela; Ionescu-Tirgoviste, Constantin] Univ Med & Pharm Carol Davila, Dept Biochem, 5th Dist, Bucharest 050474, Romania.
   [Pircalabioru, Gratiela Gradisteanu; Ciulu-Costinescu, Felicia; Chifiriuc, Mariana Carmen] Univ Bucharest, Res Inst, ICUB, 5th Dist, Bucharest 050107, Romania.
   [Bubulica, Maria-Viorica] Univ Med & Pharm Craiova, Fac Pharm, Petru Rares Str, Craiova 200638, Romania.
C3 University of Bucharest; Carol Davila University of Medicine & Pharmacy;
   University of Bucharest; University of Medicine & Pharmacy of Craiova
RP Petcu, L (corresponding author), NIDNMD Prof NC Paulescu, 2th Dist, Bucharest 020042, Romania.; Petcu, L (corresponding author), Univ Bucharest, Fac Biol, 5th Dist, Bucharest 050095, Romania.
EM arianapicu@gmail.com; madi_petcu@yahoo.com; simona_ds2002@yahoo.com;
   mani_mitu2002@yahoo.co.uk; danielalixandru@gmail.com; cit@paulescu.ro;
   gratiela87@gmail.com; felicia.costinescu@yahoo.com;
   mariaviorica.bubulica@gmail.com; carmen.chifiriuc@gmail.com
RI Ciocîlteu, Maria Viorica/IQS-2985-2023; Gradisteanu Pircalabioru,
   Gratiela/GYJ-6972-2022; Lixandru, Daniela/U-4330-2017; Chifiriuc,
   Mariana/AFP-0825-2022; Stefan, Diana/R-6148-2018
OI Diana Simona, STEFAN/0000-0001-8518-650X; GRADISTEANU PIRCALABIORU,
   GRATIELA/0000-0002-6384-1822; Chifiriuc, Mariana
   Carmen/0000-0001-6098-1857
FU Romanian National Authority for Scientific Research, CNCS-UEFISCDI
   [PN-II-IDPCE-2011-3-0429]
FX This work was supported by a grant from the Romanian National Authority
   for Scientific Research, CNCS-UEFISCDI, project number
   PN-II-IDPCE-2011-3-0429.
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NR 59
TC 40
Z9 40
U1 0
U2 3
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1420-3049
J9 MOLECULES
JI Molecules
PD MAY
PY 2017
VL 22
IS 5
AR 714
DI 10.3390/molecules22050714
PG 14
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA EZ2EP
UT WOS:000404522900037
PM 28468307
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Capone, F
   Vacca, A
   Bidault, G
   Sarver, D
   Kaminska, D
   Strocchi, S
   Vidal-Puig, A
   Greco, CM
   Lusis, AJ
   Schiattarella, GG
AF Capone, Federico
   Vacca, Antonio
   Bidault, Guillaume
   Sarver, Dylan
   Kaminska, Dorota
   Strocchi, Stefano
   Vidal-Puig, Antonio
   Greco, Carolina M.
   Lusis, Aldons J.
   Schiattarella, Gabriele G.
TI Decoding the Liver-Heart Axis in Cardiometabolic Diseases
SO CIRCULATION RESEARCH
LA English
DT Review
DE cardiometabolic risk factors; cardiovascular diseases; heart failure;
   NAFLD; obesity; systems biology
ID PRESERVED EJECTION FRACTION; VENTRICULAR DIASTOLIC DYSFUNCTION;
   GROWTH-DIFFERENTIATION FACTOR-15; FOLLISTATIN-LIKE 1; DELPHI CONSENSUS
   STATEMENT; COAGULATION-FACTOR VIII; PRECISION-CUT LIVER; MOUSE MODEL;
   NONALCOHOLIC STEATOHEPATITIS; CIRCADIAN-RHYTHMS
AB The liver and heart are closely interconnected organs, and their bidirectional interaction plays a central role in cardiometabolic disease. In this review, we summarize current evidence linking liver dysfunction-particularly metabolic dysfunction-associated steatotic liver disease, alcohol-associated liver disease, and cirrhosis-with an increased risk of heart failure and other cardiovascular diseases. We discuss how these liver conditions contribute to cardiac remodeling, systemic inflammation, and hemodynamic stress and how cardiac dysfunction in turn impairs liver perfusion and promotes hepatic injury. Particular attention is given to the molecular mediators of liver-heart communication, including hepatokines and cardiokines, as well as the emerging role of advanced research methodologies, including omics integration, proximity labeling, and organ-on-chip platforms, that are redefining our understanding of interorgan cross talk. By integrating mechanistic insights with translational tools, this review aims to support the development of multiorgan therapeutic strategies for cardiometabolic disease.
C1 [Capone, Federico; Vacca, Antonio; Strocchi, Stefano; Schiattarella, Gabriele G.] Helmholtz Assoc, Max Delbruck Ctr Mol Med, Translat Approaches Heart Failure & Cardiometab Di, Berlin, Germany.
   [Capone, Federico] Univ Padua, Padua Univ Hosp, Dept Med, Unit Internal Med 3, Padua, Italy.
   [Capone, Federico] Univ Padua, Dept Biomed Sci, Padua, Italy.
   [Vacca, Antonio] Univ Udine, Clin Med, Dept Med, Udine, Italy.
   [Bidault, Guillaume; Vidal-Puig, Antonio] Univ Cambridge, Wellcome Trust MRC Inst Metab Sci, Metab Res Labs, Cambridge, England.
   [Sarver, Dylan; Kaminska, Dorota; Lusis, Aldons J.] Univ Calif Los Angeles, Div Cardiol, Dept Med, Los Angeles, CA USA.
   [Sarver, Dylan; Lusis, Aldons J.] Univ Calif Los Angeles, Dept Microbiol Immunol & Mol Genet, Los Angeles, CA 90089 USA.
   [Sarver, Dylan; Lusis, Aldons J.] Univ Calif Los Angeles, Dept Human Genet, Los Angeles, CA USA.
   [Strocchi, Stefano; Schiattarella, Gabriele G.] Charite Univ Med Berlin, Deutsches Herzzentrum Charite, Max Rubner Ctr Cardiovasc Metab Renal Res, Berlin, Germany.
   [Vidal-Puig, Antonio] Ctr Invest Principe Felipe, Valencia, Spain.
   [Greco, Carolina M.] Humanitas Univ, Dept Biomed Sci, Milan, Italy.
   [Greco, Carolina M.] IRCCS Humanitas Res Hosp, Milan, Italy.
   [Schiattarella, Gabriele G.] German Ctr Cardiovasc Res DZHK, Berlin, Germany.
   [Schiattarella, Gabriele G.] Charite Univ Med Berlin, Friede Springer Cardiovasc Prevent Ctr, Berlin, Germany.
   [Schiattarella, Gabriele G.] Charite Univ Med Berlin, Expt & Clin Res Ctr Cooperat, Berlin, Germany.
   [Schiattarella, Gabriele G.] Univ Naples Federico II, Max Delbruck Ctr Mol Med, Div Cardiol, Dept Adv Biomed Sci, Naples, Italy.
C3 Helmholtz Association; Max Delbruck Center for Molecular Medicine;
   University of Padua; Azienda Ospedaliera - Universita di Padova;
   University of Padua; University of Udine; University of Cambridge;
   University of California System; University of California Los Angeles;
   University of California System; University of California Los Angeles;
   University of California System; University of California Los Angeles;
   Berlin Institute of Health; Free University of Berlin; Humboldt
   University of Berlin; Charite Universitatsmedizin Berlin; Prince Felipe
   Research Center; Humanitas University; German Centre for Cardiovascular
   Research; Berlin Institute of Health; Free University of Berlin;
   Humboldt University of Berlin; Charite Universitatsmedizin Berlin;
   Berlin Institute of Health; Free University of Berlin; Humboldt
   University of Berlin; Charite Universitatsmedizin Berlin; University of
   Naples Federico II
RP Schiattarella, GG (corresponding author), Charite Univ Med Berlin, Deutsch Herzzentrum Charite DHZC, Hess Str 3-4, D-10115 Berlin, Germany.
EM gabriele.schiattarella@dhzc.charite.de
RI Crawford, Dennis/JZC-9389-2024; Capone, Federico/JBJ-0302-2023; Greco,
   Carolina/G-1882-2019; Schiattarella, Gabriele/Z-2624-2019; Kaminska,
   Dorota/P-7874-2017
OI Capone, Federico/0000-0001-8127-5564; Kaminska,
   Dorota/0000-0003-1829-576X
FU DZHK (German Centre for Cardiovascular Research) [81X3100210,
   81X2100282]; Deutsche Forschungsgemein-schaft (German Research
   Foundation [SFB-1470-A02, SFB-1470-Z01]; European Research Council StG
   [101078307, 101163480]; British Heart Foundation [RG/F/23/110110];
   Medical Research Council [MC_UU_00039]; Italian Ministry of University
   and Research [P2022CXN7X, MSCA_0000075]; Cariplo Foundation [2022-0523];
   US National Institutes of Health [U54HL170326, R01DK117850, R01HL152176,
   R44DK136405]; European Research Council (ERC) [101078307] Funding
   Source: European Research Council (ERC)
FX G.G. Schiattarella was supported by DZHK (German Centre for
   Cardiovascular Research: 81X3100210 and 81X2100282), the Deutsche
   Forschungsgemein-schaft (German Research Foundation: SFB-1470-A02 and
   SFB-1470-Z01), and the European Research Council StG 101078307. G.
   Bidault and A. Vidal-Puig were supported by the British Heart Foundation
   (RG/F/23/110110) and the Medical Research Council (MC_UU_00039). C.M.
   Greco was supported by grants from the Italian Ministry of University
   and Research (grant No. P2022CXN7X and MSCA_0000075), Cariplo Foundation
   (grant No. 2022-0523), and the European Research Council ERC StG
   101163480. D. Sarver, D. Kaminska, and A.J. Lusis were supported by
   grants from the US National Institutes of Health U54HL170326,
   R01DK117850, R01HL152176, and R44DK136405.
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NR 378
TC 1
Z9 1
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0009-7330
EI 1524-4571
J9 CIRC RES
JI Circ.Res.
PD MAY 23
PY 2025
VL 136
IS 11
BP 1335
EP 1362
DI 10.1161/CIRCRESAHA.125.325492
PG 28
WC Cardiac & Cardiovascular Systems; Hematology; Peripheral Vascular
   Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Hematology
GA 2YD2Q
UT WOS:001494094400017
PM 40403112
DA 2025-06-11
ER

PT J
AU Ojetola, AA
   Asiwe, JN
   Adeyemi, WJ
   Ogundipe, DJ
   Fasanmade, AA
AF Ojetola, Abodunrin Adebayo
   Asiwe, Jerome Ndudi
   Adeyemi, Wale Johnson
   Ogundipe, Dare Joshua
   Fasanmade, Adesoji Adedipe
TI Dietary Supplementation with D-Ribose-L-Cysteine Prevents Hepatic Stress
   and Pro-Inflammatory Responses in Male Wistar Rats Fed a High-Fructose
   High-Fat Diet
SO PATHOPHYSIOLOGY
LA English
DT Article
DE D-ribose-L-cysteine; oxidative stress; inflammation; liver; high-fat
   high-fructose
ID METABOLIC SYNDROME; OXIDATIVE STRESS; GLUTATHIONE; HYPERTENSION;
   ADIPOSITY; PRODRUGS
AB Diets rich in fats and fructose are associated with the pathogenesis of oxidative stress-induced non-alcoholic fatty liver disease. Therefore, we investigated the effect of D-ribose-L-cysteine (DRLC) in high-fructose high-fat (HFHF) diet-fed rats. Twenty rats (n = 5), divided into four groups, were simultaneously exposed to HFHF and/or DRLC (250 mg/kg) orally during the 8 weeks of the study. Results showed that HFHF precipitated pro-inflammation and selective disruption of the oxidative stress markers. There were significant decreases in the level of antioxidants such as superoxide dismutase (SOD), glutathione peroxidase (GPX), total antioxidant capacity (TAC), hepatic SOD and GPX. Significant increases in serum levels of uric acid (UA), tumour necrosis factor-alpha (TNF-alpha), C-reactive protein (CRP) and hepatic Xanthine oxidase (XO) were observed in the HFHF compared to the control. In the HFHF + DRLC group, oxidative stress was mitigated due to differences in serum levels of SOD, GPX, TAC, TNF-alpha, liver SOD, and XO relative to control. The administration of DRLC alone caused significant reductions in malondialdehyde, UA and CRP and a significant increase in SOD compared to the control. DRLC prevents hepatic and systemic oxidative stress and pro-inflammatory events in HFHF diet-fed rats.
C1 [Ojetola, Abodunrin Adebayo; Fasanmade, Adesoji Adedipe] Univ Ibadan, Dept Physiol, Fac Basic Med Sci, Ibadan 200005, Nigeria.
   [Ojetola, Abodunrin Adebayo; Ogundipe, Dare Joshua] Redeemers Univ, Dept Physiol, Fac Basic Med Sci, PMB 230, Ede, Nigeria.
   [Asiwe, Jerome Ndudi] Pamo Univ Med Sci, Dept Physiol, Fac Basic Med Sci, Port Harcourt 500211, Nigeria.
   [Adeyemi, Wale Johnson] Adeleke Univ, Dept Physiol, Fac Basic Med Sci, Ede 232104, Nigeria.
C3 University of Ibadan; Redeemers University
RP Ojetola, AA (corresponding author), Univ Ibadan, Dept Physiol, Fac Basic Med Sci, Ibadan 200005, Nigeria.; Ojetola, AA (corresponding author), Redeemers Univ, Dept Physiol, Fac Basic Med Sci, PMB 230, Ede, Nigeria.
EM bodunrin.ojetola@gmail.com
RI Ojetola, Abodunrin/HGU-3972-2022; Ogundipe, Oluwdare
   Joshua/HGU-9661-2022; Ojetola, Abodunrin Adebayo/AFV-7473-2022
OI Ogundipe, Oluwdare Joshua/0000-0002-7714-6628; Asiwe, Jerome
   Ndudi/0000-0001-5600-8288; Ojetola, Abodunrin
   Adebayo/0000-0002-2374-5748
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NR 46
TC 6
Z9 6
U1 2
U2 4
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 0928-4680
EI 1873-149X
J9 PATHOPHYSIOLOGY-BASE
JI Pathophysiology
PD OCT 31
PY 2022
VL 29
IS 4
BP 631
EP 639
DI 10.3390/pathophysiology29040049
PG 9
WC Pathology
WE Emerging Sources Citation Index (ESCI)
SC Pathology
GA R3EK4
UT WOS:001063213800001
PM 36412634
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Ryu, H
   Moon, J
   Jung, J
AF Ryu, Hosihn
   Moon, Jihyeon
   Jung, Jiyeon
TI Influence of Health Behaviors and Occupational Stress on Prediabetic
   State among Male Office Workers
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Article
DE prediabetic state; health behavior; occupational stress; male; office
   worker
ID IMPAIRED FASTING GLUCOSE; LIFE-STYLE INTERVENTION; METABOLIC SYNDROME;
   RISK-FACTORS; TYPE-2; MEN; REDUCTION; ALCOHOL
AB This study examined the influence of health behaviors and occupational stress on the prediabetic state of male office workers, and identified related risks and influencing factors. The study used a cross-sectional design and performed an integrative analysis on data from regular health checkups, health questionnaires, and a health behavior-related survey of employees of a company, using Spearman's correlation coefficients and multiple logistic regression analysis. The results showed significant relationships of prediabetic state with health behaviors and occupational stress. Among health behaviors, a diet without vegetables and fruits (Odds Ratio (OR) = 3.74, 95% Confidence Interval (CI) = 1.93-7.66) was associated with a high risk of prediabetic state. In the subscales on occupational stress, organizational system in the 4th quartile (OR = 4.83, 95% CI = 2.40-9.70) was significantly associated with an increased likelihood of prediabetic state. To identify influencing factors of prediabetic state, the multiple logistic regression was performed using regression models. The results showed that dietary habits ( = 1.20, p = 0.002), total occupational stress score ( = 1.33, p = 0.024), and organizational system ( = 1.13, p = 0.009) were significant influencing factors. The present findings indicate that active interventions are needed at workplace for the systematic and comprehensive management of health behaviors and occupational stress that influence prediabetic state of office workers.
C1 [Ryu, Hosihn; Moon, Jihyeon; Jung, Jiyeon] Korea Univ, Coll Nursing, Seoul 02841, South Korea.
C3 Korea University
RP Moon, J (corresponding author), Korea Univ, Coll Nursing, Seoul 02841, South Korea.
EM hosihn@korea.ac.kr; dntkdjh222@korea.ac.kr; hepburn86@korea.ac.kr
RI Jung, Jiyeon/AAD-7727-2021
OI Jung, Jiyeon/0000-0002-8295-3424
FU Basic Science Research Program through the National Research Foundation
   of Korea [NRF-2015R1D1A1A01056938]; Nursing research Institute of Korea
   University
FX This research was supported by Basic Science Research Program through
   the National Research Foundation of Korea (Grant number:
   NRF-2015R1D1A1A01056938, PI: RYU) and Nursing research Institute of
   Korea University.
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PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD JUN
PY 2018
VL 15
IS 6
AR 1264
DI 10.3390/ijerph15061264
PG 13
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA GK8SE
UT WOS:000436496900215
PM 29904033
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Koh, IU
   Lim, JH
   Joe, MK
   Kim, WH
   Jung, MH
   Yoon, JB
   Song, J
AF Koh, In-uk
   Lim, Joo H.
   Joe, Myung K.
   Kim, Won H.
   Jung, Myeong H.
   Yoon, Jong B.
   Song, Jihyun
TI AdipoR2 is transcriptionally regulated by ER stress-inducible ATF3 in
   HepG2 human hepatocyte cells
SO FEBS JOURNAL
LA English
DT Article
DE AdipoR2; ATF3; ER stress; insulin resistance; obesity
ID ENDOPLASMIC-RETICULUM STRESS; ACTIVATED PROTEIN-KINASE; JUN NH2-TERMINAL
   KINASE; INSULIN-RESISTANCE; ADIPONECTIN RECEPTORS; GENE-EXPRESSION;
   METABOLIC SYNDROME; GLUCOSE-UTILIZATION; GAMMA AGONIST; PPAR-GAMMA
AB Adiponectin acts as an insulin-sensitizing adipokine that protects against obesity-linked metabolic disease, which is generally associated with endoplasmic reticulum (ER) stress. The physiological effects of adiponectin on energy metabolism in the liver are mediated by its receptors. We found that the hepatic expression of adiponectin receptor 2 (AdipoR2) was lower, but the expression of markers of the ER stress pathway, 78 kDa glucose-regulated protein (GRP78) and activating transcription factor 3 (ATF3), was higher in the liver of ob/ob mice compared with control mice. To investigate the regulation of AdipoR2 by ER stress, we added thapsigargin, an ER stress inducer, to a human hepatocyte cell line, HepG2. Addition of the ER stress inducer increased the levels of GRP78 and ATF3, and decreased that of AdipoR2, whereas addition of a chemical chaperone, 4-phenyl butyric acid (PBA), could reverse them. Up- or down-regulation of ATF3 modulated the AdipoR2 protein levels and AdipoR2 promoter activities. Reporter gene assays using a series of 5'-deleted AdipoR2 promoter constructs revealed the location of the repressor element responding to ER stress and ATF3. In addition, using electrophoretic mobility shift and chromatin immunoprecipitation assays, we identified a region between nucleotides -94 and -86 of the AdipoR2 promoter that functions as a putative ATF3-binding site in vitro and in vivo. Thus, our findings suggest that the ER stress-induced decrease in both protein and RNA of AdipoR2 results from a concomitant increase in expression of ATF3, which may play a role in the development of obesity-induced insulin resistance and related ER stress in hepatocytes.
C1 [Jung, Myeong H.] Pusan Natl Univ, Sch Korean Med, Yangsan Si 609735, Gyeongnam, South Korea.
   [Koh, In-uk; Lim, Joo H.; Joe, Myung K.; Kim, Won H.; Song, Jihyun] Natl Inst Hlth, Dept Biomed Sci, Div Metab Dis, Seoul, South Korea.
   [Koh, In-uk; Yoon, Jong B.] Yonsei Univ, Coll Sci, Dept Biochem, Seoul 120749, South Korea.
C3 Pusan National University; Korea Disease Control & Prevention Agency
   (KDCA); Korea National Institute of Health (KNIH); Korea CDC Center for
   Biomedical Science; Yonsei University
RP Jung, MH (corresponding author), Pusan Natl Univ, Sch Korean Med, 30 Beom Eo Ri, Yangsan Si 609735, Gyeongnam, South Korea.
EM jung0603@pusan.ac.kr; yoonj@yonsei.ac.kr; jhsong10@korea.kr
RI Kim, Wooho/G-3703-2011
OI Kim, Won-Ho/0000-0002-4849-472X; song, jihyun/0000-0003-0420-2374; Yoon,
   Jong-Bok/0000-0002-3563-0702; KOH, IN-UK/0009-0002-9288-2305
FU National Institute of Health, Korea [4845-300-210-13]
FX This work was supported by an intramural grant from the National
   Institute of Health, Korea (4845-300-210-13).
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NR 47
TC 35
Z9 42
U1 0
U2 10
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1742-464X
J9 FEBS J
JI FEBS J.
PD MAY
PY 2010
VL 277
IS 10
BP 2304
EP 2317
DI 10.1111/j.1742-4658.2010.07646.x
PG 14
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 588PM
UT WOS:000277084600011
PM 20423458
OA Bronze
DA 2025-06-11
ER

PT J
AU Amann, BL
   Radua, J
   Wunsch, C
   König, B
   Simhandl, C
AF Amann, Benedikt L.
   Radua, Joaquim
   Wunsch, Christian
   Koenig, Barbara
   Simhandl, Christian
TI Psychiatric and physical comorbidities and their impact on the course of
   bipolar disorder: A prospective, naturalistic 4-year follow-up study
SO BIPOLAR DISORDERS
LA English
DT Article
DE affective disorders; bipolar disorder; bTSH; comorbidity; relapse;
   thyroid diseases
ID ANXIETY DISORDERS; PERSONALITY-DISORDERS; LIFETIME PREVALENCE; METABOLIC
   SYNDROME; MEDICAL BURDEN; ACUTE MANIA; DSM-IV; HYPOTHYROIDISM;
   METAANALYSIS; MORTALITY
AB ObjectivesThe aim of the present study was to increase the available evidence on how physical and psychiatric comorbidities influence the long-term outcome in bipolar I and II disorder.
   MethodsWe examined the prevalence of comorbid physical (metabolic, cardiovascular, thyroid, and neurological) diseases and psychiatric (neurotic, stress-related, somatoform, and personality) disorders and their impact on the risk of relapse in bipolar disorder. A total of 284 consecutively admitted patients with ICD-10 bipolar I (n=161) and II (n=123) disorder were followed up naturalistically over a period of 4years.
   ResultsGlobally, 22.0% patients had metabolic, 18.8% cardiovascular, 18.8% thyroid, and 7.6% neurological diseases; 15.5% had neurotic, stress-related, and somatoform disorders; 12.0% had personality disorders; and 52.9% had nicotine dependence. We did not find any effect of comorbid metabolic, cardiovascular or neurological diseases or psychiatric disorders on the relapse risk. However, the presence of thyroid diseases, and especially hypothyroidism, was associated with an increased risk of manic relapse in bipolar disorder I (thyroid disease: hazard ratio [HR]=2.7; P=.003; hypothyroidism: HR=3.7;, P<.001). Among patients with hypothyroidism, higher blood levels of baseline thyroid-stimulating hormone (bTSH) were also associated with an increased risk of manic relapse (HR=1.07 per milli-international units per liter; P=.011), whereas blood levels of free triiodothyronine (fT(3)) or free thyroxine (fT(4)) were not found to have an influence.
   ConclusionsOur data underline the negative long-term impact of thyroid diseases, and especially hypothyroidism with high blood levels of bTSH, on bipolar disorder with more manic episodes, and the importance of its detection and treatment.
C1 [Amann, Benedikt L.] Inst Neuropsiquiatria & Addic, Ctr Forum Res Unit, Parc Salut Mar, Barcelona, Spain.
   [Amann, Benedikt L.] IMIM Hosp del Mar, Med Res Inst, Barcelona, Spain.
   [Amann, Benedikt L.] Autonomous Univ Barcelona, Dept Psychiat, Barcelona, Spain.
   [Amann, Benedikt L.; Radua, Joaquim] CIBERSAM, Madrid, Spain.
   [Radua, Joaquim] FIDMAG Res Fdn Germanes Hosp, Barcelona, Spain.
   [Radua, Joaquim] Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden.
   [Radua, Joaquim] Kings Coll London, Inst Psychiat Psychol & Neurosci, London, England.
   [Wunsch, Christian; Koenig, Barbara; Simhandl, Christian] Bipolar Ctr Wiener Neustadt, Vienna, Austria.
C3 Hospital del Mar Research Institute; Hospital del Mar; Hospital del Mar
   Research Institute; Hospital del Mar; Autonomous University of
   Barcelona; CIBER - Centro de Investigacion Biomedica en Red; CIBERSAM;
   Karolinska Institutet; University of London; King's College London
RP Radua, J (corresponding author), Kings Coll London, Inst Psychiat Psychol & Neurosci, Div Psychosis Studies, London, England.
EM jradua@fidmag.com
RI Radua, Joaquim/H-6424-2019
OI Radua, Joaquim/0000-0003-1240-5438; Amann, Benedikt
   L/0000-0002-4407-1519
FU Instituto de Salud Carlos III [CES 12/024, CP14/00041, PI07/1278,
   PI10/02622, PI14/00292]; Osterreichische
   Forschungsforderungsgesellschaft
FX Instituto de Salud Carlos III, Grant/Award Number: CES 12/024,
   CP14/00041, PI07/1278, PI10/02622 and PI14/00292; Osterreichische
   Forschungsforderungsgesellschaft
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NR 54
TC 33
Z9 34
U1 1
U2 11
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1398-5647
EI 1399-5618
J9 BIPOLAR DISORD
JI Bipolar Disord.
PD MAY
PY 2017
VL 19
IS 3
BP 225
EP 234
DI 10.1111/bdi.12495
PG 10
WC Clinical Neurology; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA EX5FZ
UT WOS:000403265200007
PM 28544558
DA 2025-06-11
ER

PT J
AU Guan, L
   Collet, JP
   Mazowita, G
   Claydon, VE
AF Guan, Ling
   Collet, Jean-Paul
   Mazowita, Garey
   Claydon, Victoria E.
TI Autonomic Nervous System and Sredd to Predict Secondary Ischemic Events
   after Transient Ischemic Attack or Minor Stroke: Possible Implications
   of Heart Rate Variability
SO FRONTIERS IN NEUROLOGY
LA English
DT Article
DE autonomic nervous system; stress; heart rate variability; ischemic
   stroke; transient ischemic attack; prediction
ID HEALTH-CARE PROFESSIONALS; ACUTE MYOCARDIAL-INFARCTION; FREQUENCY-DOMAIN
   MEASURES; PULSE-WAVE VELOCITY; ATRIAL-FIBRILLATION; ATHEROSCLEROSIS
   RISK; ARTERIAL STIFFNESS; METABOLIC SYNDROME; SHORT-TERM; ENDOTHELIAL
   FUNCTION
AB Transient ischemic attack (TIA) and minor stroke have high risks of recurrence and deterioration into severe ischemic strokes. Risk stratification of TIA and minor stroke is essential for early effective treatment. Traditional tools have only moderate predictive value, likely due to their inclusion of the limited number of stroke risk factors. Our review follows Hans Selye's fundamental work on stress theory and the progressive shift of the autonomic nervous system (ANS) from adaptation to disease when stress becomes chronic. We will first show that traditional risk factors and acute triggers of ischemic stroke are chronic and acute stress factors or "stressors," respectively. Our first review shows solid evidence of the relationship between chronic stress and stroke occurrence. The stress response is tightly regulated by the ANS whose function can be assessed with heart rate variability (HRV). Our second review demonstrates that stress-related risk factors of ischemic stroke are correlated with ANS dysfunction and impaired HRV. Our conclusions support the idea that HRV parameters may represent the combined effects of all body stressors that are risk factors for ischemic stroke and, thus, may be of important predictive value for the risk of subsequent ischemic events after TIA or minor stroke.
C1 [Guan, Ling; Collet, Jean-Paul] Univ British Columbia, Dept Med, Vancouver, BC, Canada.
   [Guan, Ling; Collet, Jean-Paul] Univ British Columbia, Dept Pediat, Vancouver, BC, Canada.
   [Guan, Ling; Collet, Jean-Paul] Univ British Columbia, BC Childrens Hosp Res Inst, Vancouver, BC, Canada.
   [Mazowita, Garey] Univ British Columbia, Dept Family Practice, Vancouver, BC, Canada.
   [Mazowita, Garey] Providence Healthcare, Dept Family & Community Med, Vancouver, BC, Canada.
   [Claydon, Victoria E.] Simon Fraser Univ, Dept Biomed Physiol & Kinesiol, Burnaby, BC, Canada.
C3 University of British Columbia; University of British Columbia;
   University of British Columbia; BC Children's Hospital; BC Children's
   Hospital Research Institute; University of British Columbia; Simon
   Fraser University
RP Collet, JP (corresponding author), Univ British Columbia, Dept Med, Vancouver, BC, Canada.; Collet, JP (corresponding author), Univ British Columbia, Dept Pediat, Vancouver, BC, Canada.; Collet, JP (corresponding author), Univ British Columbia, BC Childrens Hosp Res Inst, Vancouver, BC, Canada.
EM jcollet@cw.bc.ca
OI Claydon, Victoria/0000-0002-2720-8042
FU BC Children's Hospital Research Institute in Vancouver, Canada
FX J-PC is supported in part by a scholarship of the BC Children's Hospital
   Research Institute in Vancouver, Canada.
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NR 148
TC 33
Z9 39
U1 0
U2 26
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2295
J9 FRONT NEUROL
JI Front. Neurol.
PD MAR 5
PY 2018
VL 9
AR 90
DI 10.3389/fneur.2018.00090
PG 16
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology
GA FY3PK
UT WOS:000426733200001
PM 29556209
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Bailey, KA
   Haj, FG
   Simon, SI
   Passerini, AG
AF Bailey, Keith A.
   Haj, Fawaz G.
   Simon, Scott I.
   Passerini, Anthony G.
TI Atherosusceptible Shear Stress Activates Endoplasmic Reticulum Stress to
   Promote Endothelial Inflammation
SO SCIENTIFIC REPORTS
LA English
DT Article
ID CELL-ADHESION MOLECULE-1; REGULATORY FACTOR-I; VCAM-1 EXPRESSION;
   DISTURBED FLOW; ATHEROSCLEROSIS; ALPHA
AB Atherosclerosis impacts arteries where disturbed blood flow renders the endothelium susceptible to inflammation. Cytokine activation of endothelial cells (EC) upregulates VCAM-1 receptors that target monocyte recruitment to atherosusceptible regions. Endoplasmic reticulum (ER) stress elicits EC dysregulation in metabolic syndrome. We hypothesized that ER plays a central role in mechanosensing of atherosusceptible shear stress (SS) by signaling enhanced inflammation. Aortic EC were stimulated with low-dose TNF alpha (0.3 ng/ml) in a microfluidic channel that produced a linear SS gradient over a 20mm field ranging from 0-16 dynes/cm(2). High-resolution imaging of immunofluorescence along the monolayer provided a continuous spatial metric of EC orientation, markers of ER stress, VCAM-1 and ICAM-1 expression, and monocyte recruitment. VCAM-1 peaked at 2 dynes/cm(2) and decreased to below static TNF alpha-stimulated levels at atheroprotective-SS of 12 dynes/cm(2), whereas ICAM-1 rose to a maximum in parallel with SS. ER expansion and activation of the unfolded protein response also peaked at 2 dynes/cm(2), where IRF-1-regulated VCAM-1 expression and monocyte recruitment also rose to a maximum. Silencing of PECAM-1 or key ER stress genes abrogated SS regulation of VCAM-1 transcription and monocyte recruitment. We report a novel role for ER stress in mechanoregulation at arterial regions of atherosusceptible-SS inflamed by low-dose TNF alpha.
C1 [Bailey, Keith A.; Simon, Scott I.; Passerini, Anthony G.] Univ Calif Davis, Dept Biomed Engn, Davis, CA 95616 USA.
   [Haj, Fawaz G.] Univ Calif Davis, Dept Nutr, Davis, CA 95616 USA.
   [Haj, Fawaz G.] Univ Calif Davis, Dept Internal Med, Davis, CA 95616 USA.
C3 University of California System; University of California Davis;
   University of California System; University of California Davis;
   University of California System; University of California Davis
RP Passerini, AG (corresponding author), Univ Calif Davis, Dept Biomed Engn, Davis, CA 95616 USA.
EM agpasserini@ucdavis.edu
OI Passerini, Anthony/0000-0001-8007-4672
FU National Institute of Health [R01 HL082689, R01DK090492, R01DK095359]
FX The authors thank Justin Madrigal in the laboratory of Dr. Eduardo Silva
   for assistance with lentiviral transfections. This study was supported
   by National Institute of Health grants R01 HL082689 (S.I.S. and A.G.P.),
   R01DK090492 (F.G.H.), and R01DK095359 (F.G.H.).
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NR 36
TC 34
Z9 43
U1 0
U2 11
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD AUG 15
PY 2017
VL 7
AR 8196
DI 10.1038/s41598-017-08417-9
PG 11
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA FD5KT
UT WOS:000407570000073
PM 28811527
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Simao, ANC
   Victorino, VJ
   Morimoto, HK
   Reiche, EMV
   Panis, C
AF Colado Simao, Andrea Name
   Victorino, Vanessa Jacob
   Morimoto, Helena K.
   Vissoci Reiche, Edna Maria
   Panis, Carolina
TI Redox-Driven Events in the Human Immunodeficiency Virus Type 1 (HIV-1)
   Infection and their Clinical Implications
SO CURRENT HIV RESEARCH
LA English
DT Article
DE AIDS; HIV-1; NeuroAIDS; nitric oxide; nitrosative stress; oxidative
   stress; redox modifications
ID NITRIC-OXIDE SYNTHASE; KAPOSIS-SARCOMA CELLS; HUMAN T-LYMPHOCYTES;
   KAPPA-B ACTIVATION; OXIDATIVE STRESS; GLUTATHIONE DEFICIENCY;
   ANTIOXIDANT CAPACITY; TRANSGENIC RATS; IN-VIVO; EXPRESSION
AB Oxidative stress is a condition characterized by the imbalance between the production of reactive species (RS) or free radicals and their neutralization by the antioxidant defenses, leading to the accumulation of RS and their derived metabolites, with changes in the redox status of the cell. These RS can act on biological components and induce the oxidative and nitrosative reactions on lipids, proteins, and DNA. In this context, a wide variety of chronic diseases present oxidative stress as a part of the pathogenesis, including the human immunodeficiency virus type 1 (HIV-1) infection. The relationship between oxidative stress and HIV-1 infection lies in the fact that the RS species are important components of the innate immune response, and their derived metabolites and reactions participate in several events of the adaptative immune response. On the other hand, studies have shown specific roles for oxidative-driven events in both the host immunity and the virus biology. Undoubtedly, the occurrence of oxidative stress in HIV-1-infected patients has been implicated in disease progression, as well as in developing other secondary disorders, such as cardiovascular diseases, insulin resistance, and metabolic syndrome. This review aims to characterize the redox-driven events in the HIV-1 infection and their clinical implications in the disease features.
C1 [Colado Simao, Andrea Name; Morimoto, Helena K.; Vissoci Reiche, Edna Maria] Univ Estadual Londrina, Hlth Sci Ctr, Dept Pathol Clin Anal & Toxicol, Londrina, PR, Brazil.
   [Colado Simao, Andrea Name; Morimoto, Helena K.; Vissoci Reiche, Edna Maria] Univ Estadual Londrina, Univ Hosp Londrina, Clin Immunol & Mol Diag Labs, Londrina, PR, Brazil.
   [Victorino, Vanessa Jacob] Univ Sao Paulo, Fac Med, BR-09500900 Sao Paulo, Brazil.
   [Panis, Carolina] State Univ West Parana, UNIOESTE, Lab Inflammatory Mediators, Toledo, Parana, Brazil.
C3 Universidade Estadual de Londrina; Universidade Estadual de Londrina;
   Universidade de Sao Paulo; Universidade Estadual do Oeste do Parana
RP Panis, C (corresponding author), Univ Estadual Oeste Parana, UNIOESTE, Rua Maringa 1200, Francisco Beltrao, PR, Brazil.
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NR 75
TC 18
Z9 18
U1 0
U2 3
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1570-162X
EI 1873-4251
J9 CURR HIV RES
JI Curr. HIV Res.
PY 2015
VL 13
IS 2
BP 143
EP 150
DI 10.2174/1570162X13666150313152422
PG 8
WC Immunology; Infectious Diseases; Virology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Infectious Diseases; Virology
GA CG4UW
UT WOS:000353283700006
PM 25771095
DA 2025-06-11
ER

PT J
AU Wang, D
   Wei, YR
   Schmoll, D
   Maclean, KN
   Pagliassotti, MJ
AF Wang, D
   Wei, YR
   Schmoll, D
   Maclean, KN
   Pagliassotti, MJ
TI Endoplasmic reticulum stress increases glucose-6-phosphatase and glucose
   cycling in liver cells
SO ENDOCRINOLOGY
LA English
DT Article
ID UNFOLDED PROTEIN RESPONSE; H4IIE HEPATOMA-CELLS; TRANSLATIONAL CONTROL;
   INSULIN-RESISTANCE; TRANSCRIPTIONAL REGULATION; ISOLATED HEPATOCYTES;
   GENE-TRANSCRIPTION; EXPRESSION; SUCROSE; KINASE
AB Impaired regulation of hepatic glucose production is a characteristic feature of the metabolic syndrome, a cluster of diseases that includes obesity, insulin resistance, type 2 diabetes, and cardiovascular disease. It has been proposed that sustained endoplasmic reticulum stress, which appears to occur in obesity and diabetes, modulates insulin action in the liver. In this study, we show that experimental induction of endoplasmic reticulum stress increases expression and activity of glucose-6-phosphatase and the capacity for glucose release and glucose cycling in primary rat hepatocytes and H4IIE liver cells. Increased expression of the catalytic subunit of glucose-6-phosphatase was largely a result of increased transcription. Deletion analysis of the glucose-6-phosphatase promoter identified an endoplasmic reticulum stress-responsive region located between -233 and -187 with respect to the transcriptional start site. Experimental induction of endoplasmic reticulum stress increased the activity of c-jun N-terminal kinase. Prevention of endoplasmic reticulum stress-mediated activation of c-jun N-terminal kinase reduced the expression of the catalytic subunit of glucose-6-phosphatase, glucose-6-phosphatase activity, glucose release, and glucose cycling. These data demonstrate that sustained endoplasmic reticulum stress in the hepatocyte provokes adaptations, mediated in part via activation of c-jun N-terminal kinase, that act to increase hepatocellular capacity for glucose release and glucose cycling.
C1 Colorado State Univ, Dept Food Sci & Human Nutr, Ft Collins, CO 80523 USA.
   Sanofi Aventis, Therapeut Dept Metab, D-65926 Frankfurt, Germany.
   Univ Colorado, Hlth Sci Ctr, Dept Pediat, Aurora, CO 80045 USA.
C3 Colorado State University System; Colorado State University Fort
   Collins; Sanofi-Aventis; Sanofi Germany; University of Colorado System;
   University of Colorado Anschutz Medical Campus
RP Colorado State Univ, Dept Food Sci & Human Nutr, 234 Gifford Bldg, Ft Collins, CO 80523 USA.
EM pagliasm@cahs.colostate.edu
OI Schmoll, Dieter/0000-0003-2578-3366
FU NIDDK NIH HHS [DK072017, DK47416] Funding Source: Medline
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NR 52
TC 50
Z9 53
U1 0
U2 5
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0013-7227
EI 1945-7170
J9 ENDOCRINOLOGY
JI Endocrinology
PD JAN
PY 2006
VL 147
IS 1
BP 350
EP 358
DI 10.1210/en.2005-1014
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 994TG
UT WOS:000234053500038
PM 16223860
OA Bronze
DA 2025-06-11
ER

PT J
AU Damigou, E
   Kouvari, M
   Panagiotakos, D
AF Damigou, Evangelia
   Kouvari, Matina
   Panagiotakos, Demosthenes
TI The role of skeletal muscle mass on cardiovascular disease risk: an
   emerging role on modulating lipid profile
SO CURRENT OPINION IN CARDIOLOGY
LA English
DT Review
DE adiposity; cardiovascular disease; fat-free mass; skeletal muscle index;
   skeletal muscle mass
ID KOREA NATIONAL-HEALTH; REVERSE EPIDEMIOLOGY; SARCOPENIC OBESITY;
   ASSOCIATION; IMPACT; ADULTS; MEN; AGE
AB Purpose of reviewThe purpose of this review was to present updated evidence on the role of skeletal muscle mass on cardiometabolic health.Recent findingsIncreased lean, and especially skeletal, muscle mass has been associated with better cardiometabolic health in various epidemiological studies, even in younger age groups. In addition, the link between skeletal muscle mass and adult lipid profile is of interest. A preliminary analysis using the data from the ATTICA prospective cohort study (2002-2022) supports this association.Skeletal muscle mass has many metabolic functions (i.e., glucose, insulin and protein metabolism, mitochondrial function, arterial stiffness, inflammation, oxidative stress, brain function, hormone status). Given its associations with the lipid profile and overall cardiometabolic risk, skeletal muscle mass stands among the emerging risk factors for cardiovascular diseases. In addition to only using body mass index or fat distribution, more studies should evaluate lean mass and its prognostic and predictive ability regarding chronic diseases.
C1 [Damigou, Evangelia; Kouvari, Matina; Panagiotakos, Demosthenes] Harokopio Univ, Sch Hlth Sci & Educ, Dept Nutr & Dietet, Athens, Greece.
   [Panagiotakos, Demosthenes] Harokopio Univ Athens, 70 El Venizelou, Athens 17671, Greece.
C3 Harokopio University Athens; Harokopio University Athens
RP Panagiotakos, D (corresponding author), Harokopio Univ Athens, 70 El Venizelou, Athens 17671, Greece.
EM dbpanag@hua.gr
RI Kouvari, Matina/P-2308-2017; Damigou, Evangelia/LVS-6535-2024;
   Panagiotakos, Demosthenes/K-8294-2019
OI Damigou, Evangelia/0009-0002-2632-9376
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NR 56
TC 7
Z9 7
U1 2
U2 8
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0268-4705
EI 1531-7080
J9 CURR OPIN CARDIOL
JI Curr. Opin. Cardiol.
PD JUL
PY 2023
VL 38
IS 4
BP 352
EP 357
DI 10.1097/HCO.0000000000001047
PG 6
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA I1DJ2
UT WOS:001000244900013
PM 36928171
DA 2025-06-11
ER

PT J
AU Wang, TT
   Xu, H
   Wu, SS
   Guo, YX
   Zhao, GS
   Wang, DX
AF Wang, Taotao
   Xu, Hong
   Wu, Shanshan
   Guo, Yuanxin
   Zhao, Guangshan
   Wang, Dongxu
TI Mechanisms Underlying the Effects of the Green Tea Polyphenol EGCG in
   Sarcopenia Prevention and Management
SO JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
LA English
DT Review
DE EGCG; sarcopenia; tea polyphenols; skeletal muscle; aging; molecular
   mechanism
ID SKELETAL-MUSCLE ATROPHY; EPIGALLOCATECHIN-3-GALLATE MODULATES
   ANTIOXIDANT; MITOCHONDRIAL OXIDATIVE STRESS; CARDIOMETABOLIC
   RISK-FACTORS; CREB BINDING-PROTEIN; GROWTH-FACTOR; UBIQUITIN-LIGASES;
   SATELLITE CELL; MOUSE MODEL; (-)-EPIGALLOCATECHIN GALLATE
AB Sarcopenia is prevalent among the older population andseverelyaffects human health. Tea catechins may benefit for skeletal muscleperformance and protect against secondary sarcopenia. However, themechanisms underlying their antisarcopenic effect are still not fullyunderstood. Despite initial successes in animal and early clinicaltrials regarding the safety and efficacy of (-)-epigallocatechin-3-gallate(EGCG), a major catechin of green tea, many challenges, problems,and unanswered questions remain. In this comprehensive review, wediscuss the potential role and underlying mechanisms of EGCG in sarcopeniaprevention and management. We thoroughly review the general biologicalactivities and general effects of EGCG on skeletal muscle performance,EGCG's antisarcopenic mechanisms, and recent clinical evidenceof the aforesaid effects and mechanisms. We also address safety issuesand provide directions for future studies. The possible concertedactions of EGCG indicate the need for further studies on sarcopeniaprevention and management in humans.
C1 [Wang, Taotao] Jiangsu Univ, Affiliated Hosp, Dept Clin Nutr, Zhenjiang 212000, Peoples R China.
   [Xu, Hong; Guo, Yuanxin; Wang, Dongxu] Jiangsu Univ Sci & Technol, Sch Grain Sci & Technol, Zhenjiang 212100, Peoples R China.
   [Wu, Shanshan] Zhejiang Univ, Coll Agr & Biotechnol, Hangzhou 310058, Peoples R China.
   [Zhao, Guangshan] Henan Agr Univ, Coll Food Sci & Technol, Zhengzhou 450002, Peoples R China.
C3 Jiangsu University; Jiangsu University of Science & Technology; Zhejiang
   University; Henan Agricultural University
RP Guo, YX; Wang, DX (corresponding author), Jiangsu Univ Sci & Technol, Sch Grain Sci & Technol, Zhenjiang 212100, Peoples R China.; Zhao, GS (corresponding author), Henan Agr Univ, Coll Food Sci & Technol, Zhengzhou 450002, Peoples R China.
EM guoyuanxin@just.edu.cn; gszhao@henau.edu.cn; wdx@just.edu.cn
OI Wang, Dongxu/0000-0001-7377-6190; Zhao, Guangshan/0000-0002-6517-2597
FU Natural Science Foundation of Jiangsu Province [BK20210881]
FX This study was supported by Natural Science Foundation of Jiangsu
   Province (BK20210881). Figures were drawn by Figdraw (www.figdraw.com).
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NR 233
TC 12
Z9 13
U1 6
U2 55
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0021-8561
EI 1520-5118
J9 J AGR FOOD CHEM
JI J. Agric. Food Chem.
PD JUN 14
PY 2023
VL 71
IS 25
BP 9609
EP 9627
DI 10.1021/acs.jafc.3c02023
EA JUN 2023
PG 19
WC Agriculture, Multidisciplinary; Chemistry, Applied; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture; Chemistry; Food Science & Technology
GA K1GX0
UT WOS:001011554700001
PM 37316469
DA 2025-06-11
ER

PT J
AU Glban, AM
   Vasiljevic, A
   Velickovic, N
   Nikolic-Kokic, A
   Blagojevic, D
   Matic, G
   Nestorov, J
AF Glban, Alhadi M.
   Vasiljevic, Ana
   Velickovic, Natasa
   Nikolic-Kokic, Aleksandra
   Blagojevic, Dusko
   Matic, Gordana
   Nestorov, Jelena
TI The expression and activity of antioxidant enzymes in the liver of rats
   exposed to high-fructose diet in the period from weaning to adulthood
SO JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
LA English
DT Article
DE antioxidant enzymes; fructose-fed rat; liver; oxidative stress; young
   rat
ID INSULIN-RESISTANCE; OXIDATIVE STRESS; METABOLIC SYNDROME;
   SUPEROXIDE-DISMUTASE; WISTAR RATS; ENZYMATIC-ACTIVITY; CORN SYRUP;
   ENERGY; SIRT3; INFLAMMATION
AB BACKGROUNDIncreased fructose consumption correlates with rising prevalence of various metabolic disorders, some of which were linked to oxidative stress. The relationship between fructose consumption and oxidative stress is complex and effects of a fructose-rich diet on the young population have not been fully elucidated. The aim of this study was to investigate whether high-fructose diet applied in the period from weaning to adulthood induces oxidative stress in the liver, thus contributing to induction or aggravation of metabolic disturbances in later adulthood. To that end we examined the effects of high-fructose diet on expression and activity of antioxidant enzymes, markers of lipid peroxidation and protein damage in the liver as the main fructose metabolizing tissue.
   RESULTSHigh-fructose diet increased only SOD2 (mitochondrial manganese superoxide dismutase) activity, with no effect on other antioxidant enzymes, lipid peroxidation or accumulation of damaged proteins in the liver.
   CONCLUSIONThe results show that fructose-induced metabolic disturbances could not be attributed to oxidative stress, at least not at young age. The absence of oxidative stress in the liver observed herein implies that young organisms are capable of maintaining redox homeostasis when challenged by fructose-derived energy overload. (c) 2014 Society of Chemical Industry
C1 [Glban, Alhadi M.; Vasiljevic, Ana; Velickovic, Natasa; Matic, Gordana; Nestorov, Jelena] Univ Belgrade, Inst Biol Res Sinisa Stankovic, Dept Biochem, Belgrade 11060, Serbia.
   [Nikolic-Kokic, Aleksandra; Blagojevic, Dusko] Univ Belgrade, Inst Biol Res Sinisa Stankovic, Dept Physiol, Belgrade 11060, Serbia.
C3 University of Belgrade; University of Belgrade
RP Nestorov, J (corresponding author), Univ Belgrade, Inst Biol Res Sinisa Stankovic, Dept Biochem, 142 Despot Stefan Blvd, Belgrade 11000, Serbia.
EM brkljacic@ibiss.bg.ac.rs
RI Brkljacic, Jelena/JQW-4422-2023; Teofilovic, Ana/AEY-5275-2022;
   Nikolic-Kokic, Aleksandra/AAD-5591-2022; Blagojevic, Dusko/A-7739-2018;
   Matic, Gordana/N-7134-2014
OI Teofilovic, Ana/0000-0001-5731-7525; Brkljacic,
   Jelena/0000-0003-1978-8646; Nikolic-Kokic,
   Aleksandra/0000-0002-1116-2035; Blagojevic, Dusko/0000-0001-6338-2833;
   Matic, Gordana/0000-0002-0142-1056; Velickovic,
   Natasa/0000-0003-3604-5836
FU Ministry of Education, Science and Technological Development of the
   Republic of Serbia [III41009]
FX This work was supported by the Ministry of Education, Science and
   Technological Development of the Republic of Serbia, Grant III41009.
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TC 5
Z9 5
U1 0
U2 11
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-5142
EI 1097-0010
J9 J SCI FOOD AGR
JI J. Sci. Food Agric.
PD AUG 30
PY 2015
VL 95
IS 11
BP 2319
EP 2324
DI 10.1002/jsfa.6953
PG 6
WC Agriculture, Multidisciplinary; Chemistry, Applied; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture; Chemistry; Food Science & Technology
GA CL9VS
UT WOS:000357326800021
PM 25307280
DA 2025-06-11
ER

PT J
AU Skórzynska-Dziduszko, KE
   Kimber-Trojnar, Z
   Patro-Malysza, J
   Stenzel-Bembenek, A
   Oleszczuk, J
   Leszczynska-Gorzelak, B
AF Skorzynska-Dziduszko, Katarzyna E.
   Kimber-Trojnar, Zaneta
   Patro-Malysza, Jolanta
   Stenzel-Bembenek, Agnieszka
   Oleszczuk, Jan
   Leszczynska-Gorzelak, Bozena
TI Heat Shock Proteins as a Potential Therapeutic Target in the Treatment
   of Gestational Diabetes Mellitus: What We Know so Far
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE gestational diabetes mellitus; endoplasmic reticulum stress; chaperones;
   heat shock proteins; insulin resistance; inflammation; hyperglycemia;
   type 2 diabetes mellitus; metformin
ID ENDOPLASMIC-RETICULUM STRESS; PANCREATIC BETA-CELLS;
   NECROSIS-FACTOR-ALPHA; INSULIN-RESISTANCE; SKELETAL-MUSCLE; ER STRESS;
   ADIPOSE-TISSUE; CHEMICAL CHAPERONES; GLUCOSE-HOMEOSTASIS; METABOLIC
   SYNDROME
AB Gestational diabetes mellitus (GDM) is a complex condition that involves a variety of pathological mechanisms, including pancreatic -cell failure, insulin resistance, and inflammation. There is an increasing body of literature suggesting that these interrelated phenomena may arise from the common mechanism of endoplasmic reticulum (ER) stress. Both obesity-associated nutrient excess and hyperglycemia disturb ER function in protein folding and transport. This results in the accumulation of polypeptides in the ER lumen and impairs insulin secretion and signaling. Exercise elicits metabolic adaptive responses, which may help to restore normal chaperone expression in insulin-resistant tissues. Pharmacological induction of chaperones, mimicking the metabolic effect of exercise, is a promising therapeutic tool for preventing GDM by maintaining the body's natural stress response. Metformin, a commonly used diabetes medication, has recently been identified as a modulator of ER-stress-associated inflammation. The results of recent studies suggest the potential use of chemical ER chaperones and antioxidant vitamins as therapeutic interventions that can prevent glucose-induced ER stress in GDM placentas. In this review, we discuss whether chaperones may significantly contribute to the pathogenesis of GDM, as well as whether they can be a potential therapeutic target in GDM treatment.
C1 [Skorzynska-Dziduszko, Katarzyna E.] Med Univ Lublin, Dept Human Physiol, Radziwillowska 11 St, PL-20080 Lublin, Poland.
   [Kimber-Trojnar, Zaneta; Patro-Malysza, Jolanta; Oleszczuk, Jan; Leszczynska-Gorzelak, Bozena] Med Univ Lublin, Dept Obstet & Perinatol, K Jaczewskiego 8 St, PL-20954 Lublin, Poland.
   [Stenzel-Bembenek, Agnieszka] Med Univ Lublin, Dept Biochem & Mol Biol, W Chodzki 1 St, PL-20093 Lublin, Poland.
C3 Medical University of Lublin; Medical University of Lublin; Medical
   University of Lublin
RP Skórzynska-Dziduszko, KE (corresponding author), Med Univ Lublin, Dept Human Physiol, Radziwillowska 11 St, PL-20080 Lublin, Poland.
EM katarzyna.skorzynska-dziduszko@umlub.pl; zkimber@poczta.onet.pl;
   jolapatro@wp.pl; astenn@wp.pl; jan.oleszczuk@umlub.pl;
   bozena.leszczynska-gorzelak@umlub.pl
RI Skorzynska-Dziduszko, Katarzyna/K-3961-2016
OI Skorzynska-Dziduszko, Katarzyna/0000-0002-8718-1187; Patro-Malysza,
   Jolanta/0000-0002-4118-7698; Leszczynska-Gorzelak,
   Bozena/0000-0002-0221-1982; Stenzel-Bembenek,
   Agnieszka/0000-0003-1156-164X; Kimber-Trojnar,
   Zaneta/0000-0001-7295-0409
FU Medical University of Lublin [335]
FX This study was supported by the Medical University of Lublin, grant no.
   335.
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NR 79
TC 8
Z9 8
U1 0
U2 12
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD OCT
PY 2018
VL 19
IS 10
AR 3205
DI 10.3390/ijms19103205
PG 14
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA GY9HB
UT WOS:000448951000360
PM 30336561
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Ghosh, AK
   Mau, T
   O'Brien, M
   Garg, S
   Yung, R
AF Ghosh, Amiya Kumar
   Mau, Theresa
   O'Brien, Martin
   Garg, Sanjay
   Yung, Raymond
TI Impaired autophagy activity is linked to elevated ER-stress and
   inflammation in aging adipose tissue
SO AGING-US
LA English
DT Article
DE aging; adipose tissue; inflammation; ER-Stress; autophagy
ID ENDOPLASMIC-RETICULUM STRESS; LIFE-SPAN EXTENSION; CALORIE RESTRICTION;
   INSULIN-RESISTANCE; MICE; AGE; LONGEVITY; RAPAMYCIN; OBESITY;
   DYSFUNCTION
AB Adipose tissue dysfunction in aging is associated with inflammation, metabolic syndrome and other diseases. We propose that impaired protein homeostasis due to compromised lysosomal degradation (micro-autophagy) might promote aberrant ER stress response and inflammation in aging adipose tissue. Using C57BL/6 mouse model, we demonstrate that adipose tissue-derived stromal vascular fraction (SVF) cells from old (18-20 months) mice have reduced expression of autophagy markers as compared to the younger (4-6 months) cohort. Elevated expressions of ER-stress marker CHOP and autophagy substrate SQSTM1/p62 are observed in old SVFs compared to young, when treated with either vehicle or with thapsigargin (Tg), an ER stress inducer. Treatment with bafilomycin A1 (Baf), a vacuolar-type H (+)-ATPase, or Tg elevated expressions of CHOP, and SQSTM1/ p62 and LC-3-II, in 3T3-L1-preadipocytes. We also demonstrate impaired autophagy activity in old SVFs by analyzing increased accumulation of autophagy substrates LC3-II and p62. Compromised autophagy activity in old SVFs is correlated with enhanced release of pro-inflammatory cytokines IL-6 and MCP-1. Finally, SVFs from calorie restricted old mice (CR-O) have shown enhanced autophagy activity compared to ad libitum fed old mice (ALO). Our results support the notion that diminished autophagy activity with aging contributes to increased adipose tissue ER stress and inflammation.
C1 [Ghosh, Amiya Kumar; Mau, Theresa; O'Brien, Martin; Garg, Sanjay; Yung, Raymond] Univ Michigan, Dept Internal Med, Div Geriatr & Palliat Med, Ann Arbor, MI 48109 USA.
   [Yung, Raymond] Univ Michigan, VA Ann Arbor Hlth Syst, GRECC, Ann Arbor, MI 48109 USA.
C3 University of Michigan System; University of Michigan; Geriatric
   Research Education & Clinical Center; University of Michigan System;
   University of Michigan; US Department of Veterans Affairs; Veterans
   Health Administration (VHA); VA Ann Arbor Healthcare System
RP Ghosh, AK; Yung, R (corresponding author), Univ Michigan, Dept Internal Med, Div Geriatr & Palliat Med, Ann Arbor, MI 48109 USA.; Yung, R (corresponding author), Univ Michigan, VA Ann Arbor Hlth Syst, GRECC, Ann Arbor, MI 48109 USA.
EM amiyag@umich.edu; ryung@umich.edu
RI Garg, Sanjay/IUQ-1041-2023; Zambelli, Vanessa/C-2716-2013
OI Mau, Theresa/0000-0003-4278-6438
FU NIH [AG020628, AG028268, HL58984]; University of Michigan Claude D.
   Pepper Older American Independence Center [AG-024824]; Nathan Shock
   Center for the Basic Biology of Aging [AG-013283]; Aging Rodent Core
   [F034237]; Research Career Development Core (RCDC)/KL2 award [P/G
   F043686]; Research Training in Experimental Immunology Training Grant
   [T32-AI007413]; US National Institute of Health [T-32 AG000114];
   Geriatrics Research, Education and Clinical Care Center (GRECC) of the
   VA Ann Arbor Healthcare System; National Institute of Allergy and
   Infectious Diseases [T32AI007413] Funding Source: NIH RePORTER; National
   Institute on Aging [T32AG000114, P30AG024824] Funding Source: NIH
   RePORTER
FX This project has been funded in part by NIH grants AG020628 (RY),
   AG028268 (RY), HL58984 (RY), University of Michigan Claude D. Pepper
   Older American Independence Center (AG-024824 to AKG), Nathan Shock
   Center for the Basic Biology of Aging (AG-013283 to AKG), Aging Rodent
   Core (F034237 to AKG), and Research Career Development Core (RCDC)/KL2
   award (P/G F043686 to AKG), 'Research Training in Experimental
   Immunology Training Grant' (T32-AI007413 to TM), US National Institute
   of Health Grants (T-32 AG000114 to TM) and Geriatrics Research,
   Education and Clinical Care Center (GRECC) of the VA Ann Arbor
   Healthcare System (RY). The content is solely the responsibility of the
   authors and does not necessarily represent the official views of the
   NIH.
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NR 49
TC 71
Z9 78
U1 0
U2 9
PU IMPACT JOURNALS LLC
PI ALBANY
PA 6211 TIPTON HOUSE, STE 6, ALBANY, NY 12203 USA
SN 1945-4589
J9 AGING-US
JI Aging-US
PD OCT
PY 2016
VL 8
IS 10
BP 2525
EP +
DI 10.18632/aging.101083
PG 13
WC Cell Biology; Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Cell Biology; Geriatrics & Gerontology
GA EF4OZ
UT WOS:000390311800021
PM 27777379
OA gold, Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Hanson, LLM
   Westerlund, H
   Goldberg, M
   Zins, M
   Vahtera, J
   Rod, NH
   Stenholm, S
   Steptoe, A
   Kivimäki, M
AF Hanson, Linda L. Magnusson
   Westerlund, Hugo
   Goldberg, Marcel
   Zins, Marie
   Vahtera, Jussi
   Rod, Naja Hulvej
   Stenholm, Sari
   Steptoe, Andrew
   Kivimaki, Mika
TI Work stress, anthropometry, lung function, blood pressure, and
   blood-based biomarkers: a cross-sectional study of 43,593 French men and
   women
SO SCIENTIFIC REPORTS
LA English
DT Article
ID EFFORT-REWARD IMBALANCE; POPULATION-BASED COHORT;
   CORONARY-HEART-DISEASE; JOB DECISION LATITUDE; CARDIOVASCULAR-DISEASE;
   METABOLIC SYNDROME; RISK-FACTOR; STRAIN; ENVIRONMENT; METAANALYSIS
AB Work stress is a risk factor for cardio-metabolic diseases, but few large-scale studies have examined the clinical profile of individuals with work stress. To address this limitation, we conducted a cross-sectional study including 43,593 working adults from a French population-based sample aged 18-72 years (the CONSTANCES cohort). According to the Effort-Reward Imbalance model, work stress was defined as an imbalance between perceived high efforts and low rewards at work. A standardized health examination included measures of anthropometry, lung function, blood pressure and standard blood-based biomarkers. Linear regression analyses before and after multivariable adjustment for age, socioeconomic status, depressive symptoms, health-related behaviours, and chronic conditions showed that work stress was associated with higher BMI, waist circumference, waist-hip ratio, alanine transaminase, white blood cell count and lower high-density lipoprotein cholesterol in men, and with higher BMI and white blood cell count in women (differences 0.03-0.06 standard deviations, P < 0.05 between individuals with and without work stress). No robust associations were observed with lung function, haemoglobin, creatinine, glucose levels or resting blood pressure measures. This indicates that work stress is associated altered metabolic profile, increased systemic inflammation, and, in men, poorer liver function, which is a marker of high alcohol consumption.
C1 [Hanson, Linda L. Magnusson; Westerlund, Hugo] Stockholm Univ, Stress Res Inst, Stockholm, Sweden.
   [Westerlund, Hugo] Karolinska Inst, Div Insurance Med, Dept Clin Neurosci, Stockholm, Sweden.
   [Goldberg, Marcel; Zins, Marie] INSERM, Populat Based Epidemiol Cohorts Unit UMS 011, Villejuif, France.
   [Goldberg, Marcel; Zins, Marie] Paris Descartes Univ, Paris, France.
   [Vahtera, Jussi; Stenholm, Sari] Univ Turku, Dept Publ Hlth, Turku, Finland.
   [Vahtera, Jussi; Stenholm, Sari] Turku Univ Hosp, Turku, Finland.
   [Rod, Naja Hulvej] Univ Copenhagen, Dept Publ Hlth, Copenhagen, Denmark.
   [Steptoe, Andrew] UCL, Dept Behav Sci & Hlth, London, England.
   [Kivimaki, Mika] Univ Helsinki, Clinicum, Fac Med, Helsinki, Finland.
   [Kivimaki, Mika] UCL, Dept Epidemiol & Publ Hlth, London, England.
C3 Stockholm University; Karolinska Institutet; Universite Paris Cite;
   Institut National de la Sante et de la Recherche Medicale (Inserm);
   Universite Paris Cite; University of Turku; University of Turku;
   University of Copenhagen; University of London; University College
   London; University of Helsinki; University of London; University College
   London
RP Hanson, LLM (corresponding author), Stockholm Univ, Stress Res Inst, Stockholm, Sweden.
EM linda.hanson@su.se
RI Steptoe, Andrew/Y-2440-2019; Westerlund, Hugo/IZP-7925-2023; Zins,
   Marie/AAX-6551-2021; Vahtera, Jussi/J-3271-2013; Kivimaki,
   Mika/B-3607-2012; Magnusson Hanson, Linda/D-2435-2017; Goldberg,
   Marcel/I-7834-2012; Rod, Naja Hulvej/B-9411-2015
OI Magnusson Hanson, Linda/0000-0002-2908-1903; Goldberg,
   Marcel/0000-0002-6161-5880; Kivimaki, Mika/0000-0002-4699-5627; Rod,
   Naja Hulvej/0000-0002-6400-5105; Vahtera, Jussi/0000-0002-6036-061X
FU Nordic Research Programme on Health and Welfare; UK Medical Research
   Council [K013351]; Academy of Finland [311492]; Finnish Work Environment
   Fund; Caisse nationale d'assurance maladie des travailleurs salaries
   (CNAMTS); ANR [ANR-11-INBS-0002]; MSD; AstraZeneca; Lundbeck; NordForsk;
   ESRC [ES/J023299/1] Funding Source: UKRI; MRC [MR/K013351/1] Funding
   Source: UKRI
FX The authors are grateful to NordForsk, the Nordic Research Programme on
   Health and Welfare, for supporting the study. Mika Kivimaki is also
   support by the UK Medical Research Council (K013351), the Academy of
   Finland (311492) and the Finnish Work Environment Fund. The CONSTANCES
   cohort is supported by the Caisse nationale d'assurance maladie des
   travailleurs salaries (CNAMTS) and by a grant from ANR
   (ANR-11-INBS-0002), and it is also partly funded by MSD, AstraZeneca and
   Lundbeck. The authors also wish to thank Stephen Goldberg and Alice
   Gueguen, Population-based Epidemiological Cohorts Unit, INSERM UMS 11,
   Villejuif, France.
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NR 51
TC 34
Z9 35
U1 1
U2 23
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD AUG 24
PY 2017
VL 7
AR 9282
DI 10.1038/s41598-017-07508-x
PG 9
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Science & Technology - Other Topics
GA FE8FS
UT WOS:000408441600006
PM 28839130
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Heine, RJ
   Dekker, JM
AF Heine, RJ
   Dekker, JM
TI Beyond postprandial hyperglycaemia: metabolic factors associated with
   cardiovascular disease
SO DIABETOLOGIA
LA English
DT Review
DE Type II diabetes; postprandial hyperglycaemia; postprandial
   hypertriglyceridaemia; dyslipidaemia; cardiovascular disease; insulin
   resistance; atherosclerosis; oral hypoglycaemic agents; endothelial
   function; oxidative stress; QT interval
ID CORONARY-HEART-DISEASE; IMPAIRED GLUCOSE-TOLERANCE; INTIMA-MEDIA
   THICKNESS; LOW-DENSITY-LIPOPROTEIN; DEPENDENT DIABETES-MELLITUS; COMMON
   CAROTID-ARTERY; RISK-FACTORS; INSULIN-RESISTANCE; ENDOTHELIAL
   DYSFUNCTION; OXIDATIVE STRESS
AB Type II (non-insulin-dependent) diabetes mellitus is associated with a considerably enhanced risk of cardiovascular disease morbidity and mortality. Several epidemiological studies have shown an association between the 2-h glucose value after a 75 gm glucose load (2hPG) and mortality from all causes and from cardiovascular disease. The key question is whether postprandial glucose is related causally to the adverse outcomes (risk factors) or just a marker of risk. Since insulin resistance is one of the determinants of the 2hPG, factors associated with the insulin resistance syndrome, in particular postprandial hypertriglyceridaemia, also need to be considered. Glycaemic excursions could contribute to oxidative stress, endothelial dysfunction, formation of advanced glycation end-products and prolongation of the OR interval. However, high postprandial concentrations of triglyceride rich lipoproteins, which can be partly attributed to obesity and insulin resistance, have now been recognised to affect endothelial function, to promote atherogenesis, and to be associated with coronary artery disease. On the basis of present evidence Type II diabetic patients require good overall glycaemic control, as reflected by target values of HbA(1c). However, postprandial hyperglycaemia should be considered as a marker of underlying metabolic abnormalities. Therefore, at present there is no evidence to support the recommendation to consider postprandial hyperglycaemia as a treatment target in itself and would thus require intervention studies showing added benefit of selectively targeting at meal-related glucose excursions in patients with an adequate HbA(1c). Drugs aiming at improving only postprandial glucose values are not likely to lower the excess mortality associated with Type II diabetes.
C1 Vrije Univ Amsterdam Med Ctr, Dept Endocrinol, Ctr Diabet, NL-1081 HV Amsterdam, Netherlands.
   Vrije Univ Amsterdam Med Ctr, Inst Res Extramural Med, Amsterdam, Netherlands.
C3 Vrije Universiteit Amsterdam; VU UNIVERSITY MEDICAL CENTER; Vrije
   Universiteit Amsterdam; VU UNIVERSITY MEDICAL CENTER
RP Vrije Univ Amsterdam Med Ctr, Dept Endocrinol, Ctr Diabet, Boeleaan 1118, NL-1081 HV Amsterdam, Netherlands.
EM RJ.Heine@vumc.nl
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NR 145
TC 109
Z9 129
U1 0
U2 2
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0012-186X
EI 1432-0428
J9 DIABETOLOGIA
JI Diabetologia
PD APR
PY 2002
VL 45
IS 4
BP 461
EP 475
DI 10.1007/s00125-001-0726-0
PG 15
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 557YL
UT WOS:000175936600001
PM 12032622
OA Bronze
DA 2025-06-11
ER

PT J
AU Nafar, M
   Sahraei, Z
   Salamzadeh, J
   Samavat, S
   Vaziri, ND
AF Nafar, Mohsen
   Sahraei, Zahra
   Salamzadeh, Jamshid
   Samavat, Shiva
   Vaziri, Nosartolah D.
TI Oxidative Stress in Kidney Transplantation Causes, Consequences, and
   Potential Treatment
SO IRANIAN JOURNAL OF KIDNEY DISEASES
LA English
DT Review
DE kidney transplantation; oxidative stress; reperfusion injury; kidney
   failure
ID ISCHEMIA-REPERFUSION INJURY; STAGE RENAL-DISEASE; CHRONIC ALLOGRAFT
   NEPHROPATHY; UNIVERSITY-OF-WISCONSIN; NITRIC-OXIDE SYNTHASE;
   HEART-BEATING-DONORS; RAT-KIDNEY; N-ACETYLCYSTEINE; ISCHEMIA/REPERFUSION
   INJURY; GLUTATHIONE-PEROXIDASE
AB Oxidative stress is a major mediator of adverse outcomes throughout the course of transplantation. Transplanted kidneys are prone to oxidative stress-mediated injury by pre-transplant and post-transplant conditions that cause reperfusion injury or imbalance between oxidants and antioxidants. Besides adversely affecting the allograft, oxidative stress and its constant companion, inflammation, cause cardiovascular disease, cancer, metabolic syndrome, and other disorders in transplant recipients. Presence and severity of oxidative stress can be assessed by various biomarkers produced from interaction of reactive oxygen species with lipids, proteins, nucleic acids, nitric oxide, glutathione, etc. In addition, expression and activities of redox-sensitive molecules such as antioxidant enzymes can serve as biomarkers of oxidative stress. Via activation of nuclear factor kappa B, oxidative stress promotes inflammation which, in turn, amplifies oxidative stress through reactive oxygen species generation by activated immune cells. Therefore, inflammation markers are indirect indicators of oxidative stress. Many treatment options have been evaluated in studies conducted at different stages of transplantation in humans and animals. These studies have provided useful strategies for use in donors or in organ preservation solutions. However, strategies tested for use in post-transplant phase have been largely inconclusive and controversial. A number of therapeutic options have been exclusively examined in animal models and only a few have been tested in humans. Most of the clinical investigations have been of short duration and have provided no insight into their impact on the long-term survival of transplant patients. Effective treatment of oxidative stress in transplant population remains elusive and awaits future explorations.
C1 [Nafar, Mohsen; Sahraei, Zahra; Samavat, Shiva] Shahid Beheshti Univ Med Sci, Dept Internal Med, Shahid Labbafinejad Med Ctr, Tehran, Iran.
   [Nafar, Mohsen; Samavat, Shiva] Shahid Beheshti Univ Med Sci, Urol & Nephrol Res Ctr, Tehran, Iran.
   [Sahraei, Zahra; Salamzadeh, Jamshid] Shahid Beheshti Univ Med Sci, Dept Clin Pharm, Sch Pharm, Tehran, Iran.
   [Vaziri, Nosartolah D.] Univ Calif Irvine, Div Nephrol & Hypertens, Irvine, CA USA.
C3 Shahid Beheshti University Medical Sciences; Shahid Beheshti University
   Medical Sciences; Shahid Beheshti University Medical Sciences;
   University of California System; University of California Irvine
RP Sahraei, Z (corresponding author), Shahid Beheshti Univ Med Sci, Dept Internal Med, Shahid Labbafinejad Med Ctr, 9th Boustan St,Pasdaran Ave, Tehran, Iran.
EM z_sahraee@yahoo.com
RI nafar, mohsen/ABG-4171-2021; Samavat, Shiva/AAU-4894-2021; Salamzadeh,
   Jamshid/KBB-1686-2024
OI Nafar, Mohsen/0000-0001-5636-2666; Samavat, Shiva/0000-0001-6707-7844
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NR 137
TC 75
Z9 78
U1 0
U2 9
PU IRANIAN SOC NEPHROLGY
PI TEHRAN
PA APT 12, NO 63, SHAHEED TOUSI ST, DR GHARIB ST, KESHAVARZ BLVD, TEHRAN,
   1419783311, IRAN
SN 1735-8582
EI 1735-8604
J9 IRAN J KIDNEY DIS
JI Iran. J. Kidney Dis.
PD NOV
PY 2011
VL 5
IS 6
BP 357
EP 372
PG 16
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 849OI
UT WOS:000297134500001
PM 22057066
DA 2025-06-11
ER

PT J
AU Bachmann, MC
   Bellalta, S
   Basoalto, R
   Gómez-Valenzuela, F
   Jalil, Y
   Lépez, M
   Matamoros, A
   von Bernhardi, R
AF Bachmann, Maria Consuelo
   Bellalta, Sofia
   Basoalto, Roque
   Gomez-Valenzuela, Fernan
   Jalil, Yorschua
   Lepez, Macarena
   Matamoros, Anibal
   von Bernhardi, Rommy
TI The Challenge by Multiple Environmental and Biological Factors Induce
   Inflammation in Aging: Their Role in the Promotion of Chronic Disease
SO FRONTIERS IN IMMUNOLOGY
LA English
DT Review
DE pollution; oxidative stress; nutrition; immune system; gender; exercise;
   epigenetic changes; drug abuse
ID FATTY-ACID-COMPOSITION; HEALTHY NORDIC DIET; BALTIC SEA DIET;
   DOCOSAHEXAENOIC ACID; OXIDATIVE STRESS; IMMUNE-RESPONSE;
   SKELETAL-MUSCLE; ADIPOSE-TISSUE; AIR-POLLUTION; CARDIOMETABOLIC RISK
AB The aging process is driven by multiple mechanisms that lead to changes in energy production, oxidative stress, homeostatic dysregulation and eventually to loss of functionality and increased disease susceptibility. Most aged individuals develop chronic low-grade inflammation, which is an important risk factor for morbidity, physical and cognitive impairment, frailty, and death. At any age, chronic inflammatory diseases are major causes of morbimortality, affecting up to 5-8% of the population of industrialized countries. Several environmental factors can play an important role for modifying the inflammatory state. Genetics accounts for only a small fraction of chronic-inflammatory diseases, whereas environmental factors appear to participate, either with a causative or a promotional role in 50% to 75% of patients. Several of those changes depend on epigenetic changes that will further modify the individual response to additional stimuli. The interaction between inflammation and the environment offers important insights on aging and health. These conditions, often depending on the individual's sex, appear to lead to decreased longevity and physical and cognitive decline. In addition to biological factors, the environment is also involved in the generation of psychological and social context leading to stress. Poor psychological environments and other sources of stress also result in increased inflammation. However, the mechanisms underlying the role of environmental and psychosocial factors and nutrition on the regulation of inflammation, and how the response elicited for those factors interact among them, are poorly understood. Whereas certain deleterious environmental factors result in the generation of oxidative stress driven by an increased production of reactive oxygen and nitrogen species, endoplasmic reticulum stress, and inflammation, other factors, including nutrition (polyunsaturated fatty acids) and behavioral factors (exercise) confer protection against inflammation, oxidative and endoplasmic reticulum stress, and thus ameliorate their deleterious effect. Here, we discuss processes and mechanisms of inflammation associated with environmental factors and behavior, their links to sex and gender, and their overall impact on aging.
C1 [Bachmann, Maria Consuelo; Bellalta, Sofia; Basoalto, Roque; Gomez-Valenzuela, Fernan; Jalil, Yorschua; Lepez, Macarena; Matamoros, Anibal; von Bernhardi, Rommy] Pontificia Univ Catolica Chile, Sch Med, Santiago, Chile.
   [Matamoros, Anibal] Fed Univ Para, Inst Biol Sci ICB, Belem, Para, Brazil.
C3 Pontificia Universidad Catolica de Chile; Universidade Federal do Para
RP von Bernhardi, R (corresponding author), Pontificia Univ Catolica Chile, Sch Med, Santiago, Chile.
EM rvonb@med.puc.cl
RI Gómez-Valenzuela, Fernán/KEJ-1839-2024; von Bernhardi,
   Rommy/IAO-3764-2023; Bachmann, María/ADS-2151-2022
OI Lepez, Macarena/0000-0003-1743-2910; von Bernhardi,
   Rommy/0000-0002-9022-7676; Jalil Contreras, Yorschua
   Frederick/0000-0002-4993-7158; Gomez-Valenzuela,
   Fernan/0000-0001-6889-976X
FU CONICYT Program of Chile [FONDECYT 1171645]; Santander Universia
   Research Award in aging research; CONICYT-PFCHA/Doctorado Nacional
   2019-Folio [21191070, 21191025, 21190421]; CONICYT-PFCHA/Doctorado
   Nacional 2020-Folio [21201751, 21201210]
FX This work was partially supported by Project FONDECYT 1171645 from
   CONICYT Program of Chile and the Santander Universia Research Award in
   aging research (RBe). SB, YJ, and FG acknowledge partial support from
   CONICYT-PFCHA/Doctorado Nacional 2019-Folio 21191070, 21191025 and
   21190421, respectively. RBa and JM acknowledge partial support from
   CONICYT-PFCHA/Doctorado Nacional 2020-Folio 21201751 and 21201210,
   respectively.
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NR 284
TC 44
Z9 45
U1 2
U2 28
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-3224
J9 FRONT IMMUNOL
JI Front. Immunol.
PD OCT 14
PY 2020
VL 11
AR 570083
DI 10.3389/fimmu.2020.570083
PG 19
WC Immunology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Immunology
GA OK1CB
UT WOS:000584388200001
PM 33162985
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Cormie, P
   Turner, B
   Kaczmarek, E
   Drake, D
   Chambers, SK
AF Cormie, Prue
   Turner, Brooke
   Kaczmarek, Elizabeth
   Drake, Deirdre
   Chambers, Suzanne K.
TI A Qualitative Exploration of the Experience of Men With Prostate Cancer
   Involved in Supervised Exercise Programs
SO ONCOLOGY NURSING FORUM
LA English
DT Article
DE exercise; prostate cancer; supportive care; survivorship care
ID ANDROGEN-DEPRIVATION THERAPY; OF-LIFE; RESISTANCE EXERCISE; SUPPRESSION
   THERAPY; METABOLIC SYNDROME; AEROBIC EXERCISE; BONE METASTASES; HEALTH;
   FAT; MASCULINITIES
AB Purpose/Objectives: To provide an in-depth description of the experience of supervised exercise programs among men with prostate cancer and to identify elements critical to optimizing engagement and ongoing exercise participation.
   Design: Descriptive, qualitative. Setting: A tertiary exercise oncology center in Perth, Australia.
   Sample: 12 men with prostate cancer participating in a structured, clinic-based group exercise program supervised by accredited exercise physiologists.
   Methodologic Approach: Participants completed a demographic and health history questionnaire and a semistructured interview. Thematic content analysis was performed.
   Findings: Participants described physiological and psychological health benefits, which reduced treatment-related side effects and positively affected self-efficacy, and identified exercise physiologists as providing information about the importance of exercise, as well as practical, emotional, and social support. Peer support encouraged discussion of shared experiences and a sense of social connection.
   Conclusions: Results from the current study expand on existing quantitative data to provide evidence of psychosocial benefits among men with prostate cancer involved with supervised exercise programs. The data provide insight into the components of exercise programs that can form a framework for the development of effective supportive care programs.
   Interpretation: Involvement in a structured, clinic-based group exercise program provides men with prostate cancer with considerable benefits. Supervision by qualified exercise physiologists and incorporation of a group approach are critical components of maximizing those benefits.
C1 [Cormie, Prue] ECU, Hlth & Wellness Inst, Joondalup, Australia.
   [Turner, Brooke] Govt Western Australia, Dept Correct Serv, Perth, WA, Australia.
   [Kaczmarek, Elizabeth; Drake, Deirdre] ECU, Dept Psychol & Social Sci, Joondalup, Australia.
   [Chambers, Suzanne K.] Griffith Univ, Griffith Hlth Inst, Southport, Qld 4215, Australia.
C3 Edith Cowan University; Edith Cowan University; Menzies Health Institute
   Queensland; Griffith University; Griffith University - Gold Coast Campus
RP Cormie, P (corresponding author), ECU, Hlth & Wellness Inst, Joondalup, Australia.
EM p.cormie@ecu.edu.au
RI Chambers, Suzanne/H-5957-2012; Cormie, Prue/C-6669-2009
OI Chambers, Suzanne K/0000-0003-2369-6111; Cormie,
   Prue/0000-0002-3446-2698
FU Cancer Council Western Australia Postdoctoral Research Fellowship;
   Australian Research Council Professorial Future Fellowship
FX Prue Cormie, PhD, is a senior research fellow at the Edith Cowan
   University (ECU) Health and Wellness Institute in Joondalup, Australia;
   Brooke Turner, MPsych, is a clinical psychologist in the Department of
   Corrective Services for the Government of Western Australia in Perth;
   Elizabeth Kaczmarek, PhD, is a lecturer, and Deirdre Drake, PhD, is a
   senior lecturer, both in the Department of Psychology and Social Science
   at ECU; and Suzanne K. Chambers, RN, PhD, is a professor of preventative
   health in the Griffith Health Institute at Griffith University in
   Southport, Australia. This study was supported, in part, by a Cancer
   Council Western Australia Postdoctoral Research Fellowship to Cormie and
   an Australian Research Council Professorial Future Fellowship to
   Chambers. Cormie can be reached at p.cormie@ecu.edu.au, with copy to
   editor at ONFEditor@ons.org. (Submitted May 2014. Accepted for
   publication August 4, 2014.)
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NR 52
TC 34
Z9 35
U1 0
U2 17
PU ONCOLOGY NURSING SOC
PI PITTSBURGH
PA 125 ENTERPRISE DR, PITTSBURGH, PA 15275 USA
SN 0190-535X
EI 1538-0688
J9 ONCOL NURS FORUM
JI Oncol. Nurs. Forum
PD JAN
PY 2015
VL 42
IS 1
BP 24
EP 32
DI 10.1188/15.ONF.24-32
PG 9
WC Oncology; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Oncology; Nursing
GA AX3QO
UT WOS:000346854300009
PM 25542318
OA Green Published
DA 2025-06-11
ER

PT J
AU Ruiz-Ramírez, A
   Chávez-Salgado, M
   Peñeda-Flores, JA
   Zapata, E
   Masso, F
   El-Hafidi, M
AF Ruiz-Ramirez, Angelica
   Chavez-Salgado, Monserrath
   Peneda-Flores, Jose Antonio
   Zapata, Estrella
   Masso, Felipe
   El-Hafidi, Mohammed
TI High-sucrose diet increases ROS generation, FFA accumulation, UCP2
   level, and proton leak in liver mitochondria
SO AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
LA English
DT Article
DE reactive oxygen species; free fatty acid; metabolic syndrome;
   mitochondrial function; oxidative stress; uncoupling protein 2
ID FREE FATTY-ACIDS; OXYGEN SPECIES PRODUCTION; UNCOUPLING PROTEIN-2;
   SUPEROXIDE-DISMUTASE; INSULIN-RESISTANCE; METABOLIC SYNDROME; OXIDATIVE
   STRESS; COMPLEX-I; DYSFUNCTION; EXPRESSION
AB Ruiz-Ramirez A, Chavez-Salgado M, Peneda-Flores JA, Zapata E, Masso F, El-Hafidi M. High-sucrose diet increases ROS generation, FFA accumulation, UCP2 level, and proton leak in liver mitochondria. Am J Physiol Endocrinol Metab 301: E1198-E1207, 2011. First published September 13, 2011; doi: 10.1152/ajpendo.00631.2010.-Obesity, a risk factor for insulin resistance, contributes to the development of type 2 diabetes and cardiovascular diseases. The relationship between increased levels of free fatty acids in the liver mitochondria, mitochondrial function, and ROS generation in rat model of obesity induced by a high-sucrose diet was not sufficiently established. We determined how the bioenergetic functions and ROS generation of the mitochondria respond to a hyperlipidemic environment. Mitochondria from sucrose-fed rats generated H2O2 at a higher rate than the control mitochondria. Adding fatty acid-free bovine serum albumin to mitochondria from sucrose-fed rats significantly reduced the rate of H2O2 generation. In contrast, adding exogenous oleic or linoleic acid exacerbated the rate of H2O2 generation in both sucrose-fed and control mitochondria, and the mitochondria from sucrose-fed rats were more sensitive than the control mitochondria. The increased rate of H2O2 generation in sucrose-fed mitochondria corresponded to decreased levels of reduced GSH and vitamin E and increased levels of Cu/Zn-SOD in the intermembrane space. There was no difference between the levels of lipid peroxidation and protein carbonylation in the two types of mitochondria. In addition to the normal activity of Mn-SOD, GPX and catalase detected an increased activity of complex II, and upregulation of UCP2 was observed in mitochondria from sucrose-fed rats, all of which may accelerate respiration rates and reduce generation of ROS. In turn, these effects may protect the mitochondria of sucrose-fed rats from oxidative stress and preserve their function and integrity. However, in whole liver these adaptive mechanisms of the mitochondria were inefficient at counteracting redox imbalances and inhibiting oxidative stress outside of the mitochondria.
C1 [Ruiz-Ramirez, Angelica; Chavez-Salgado, Monserrath; Peneda-Flores, Jose Antonio; Zapata, Estrella; Masso, Felipe; El-Hafidi, Mohammed] Natl Inst Cardiol Ignacio Chavez, Tlalpan, Mexico.
C3 National Institute of Cardiology - Mexico
RP El-Hafidi, M (corresponding author), Natl Inst Cardiol Ignacio Chavez, Cardiovasc Biomed Dept, Juan Badiano 1,Colonia Secc 16, Mexico City 14080, DF, Mexico.
EM medelhafidi@yahoo.com
RI El-Hafidi, Mohammed/AAN-4083-2021
FU Institute of Science and Technology of the Federal District, Mexico City
   (ICyTDF), Mexico [PICDS08-67]; National Autonomous University of Mexico
FX This work was supported in part by the Institute of Science and
   Technology of the Federal District, Mexico City (ICyTDF), Mexico (Grant
   No. PICDS08-67). We greatly acknowledge the partial support from the
   doctorate program in Biological Sciences of the National Autonomous
   University of Mexico to Angelica Ruiz-Ramirez.
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NR 60
TC 87
Z9 94
U1 0
U2 20
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0193-1849
EI 1522-1555
J9 AM J PHYSIOL-ENDOC M
JI Am. J. Physiol.-Endocrinol. Metab.
PD DEC
PY 2011
VL 301
IS 6
BP E1198
EP E1207
DI 10.1152/ajpendo.00631.2010
PG 10
WC Endocrinology & Metabolism; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Physiology
GA 863CT
UT WOS:000298141100017
PM 21917631
DA 2025-06-11
ER

PT J
AU Bolton, JL
   Hayward, C
   Direk, N
   Lewis, JG
   Hammond, GL
   Hill, LA
   Anderson, A
   Huffman, J
   Wilson, JF
   Campbell, H
   Rudan, I
   Alan, W
   Hastie, N
   Wild, SH
   Velders, FP
   Hofman, A
   Uitterlinden, AG
   Lahti, J
   Räikkönen, K
   Kajantie, E
   Widen, E
   Palotie, A
   Eriksson, JG
   Kaakinen, M
   Jarvelin, MR
   Timpson, NJ
   Smith, GD
   Ring, SM
   Evans, DM
   St Pourcain, B
   Tanaka, T
   Milaneschi, Y
   Bandinelli, S
   Ferrucci, L
   van der Harst, P
   Rosmalen, JGM
   Bakker, SJL
   Verweij, N
   Dullaart, RPF
   Mahajan, A
   Lindgren, CM
   Morris, A
   Lind, L
   Ingelsson, E
   Anderson, LN
   Pennell, CE
   Lye, SJ
   Matthews, SG
   Eriksson, J
   Mellstrom, D
   Ohlsson, C
   Price, JF
   Strachan, MWJ
   Reynolds, RM
   Tiemeier, H
   Walker, BR
AF Bolton, Jennifer L.
   Hayward, Caroline
   Direk, Nese
   Lewis, John G.
   Hammond, Geoffrey L.
   Hill, Lesley A.
   Anderson, Anna
   Huffman, Jennifer
   Wilson, James F.
   Campbell, Harry
   Rudan, Igor
   Wright, Alan
   Hastie, Nicholas
   Wild, Sarah H.
   Velders, Fleur P.
   Hofman, Albert
   Uitterlinden, Andre G.
   Lahti, Jari
   Raikkonen, Katri
   Kajantie, Eero
   Widen, Elisabeth
   Palotie, Aarno
   Eriksson, Johan G.
   Kaakinen, Marika
   Jarvelin, Marjo-Riitta
   Timpson, Nicholas J.
   Smith, George Davey
   Ring, Susan M.
   Evans, David M.
   St Pourcain, Beate
   Tanaka, Toshiko
   Milaneschi, Yuri
   Bandinelli, Stefania
   Ferrucci, Luigi
   van der Harst, Pim
   Rosmalen, Judith G. M.
   Bakker, Stephen J. L.
   Verweij, Niek
   Dullaart, Robin P. F.
   Mahajan, Anubha
   Lindgren, Cecilia M.
   Morris, Andrew
   Lind, Lars
   Ingelsson, Erik
   Anderson, Laura N.
   Pennell, Craig E.
   Lye, Stephen J.
   Matthews, Stephen G.
   Eriksson, Joel
   Mellstrom, Dan
   Ohlsson, Claes
   Price, Jackie F.
   Strachan, Mark W. J.
   Reynolds, Rebecca M.
   Tiemeier, Henning
   Walker, Brian R.
CA CORtisol Network CORNET Consortium
TI Genome Wide Association Identifies Common Variants at the
   SERPINA6/SERPINA1 Locus Influencing Plasma Cortisol and
   Corticosteroid Binding Globulin
SO PLOS GENETICS
LA English
DT Article
ID INSULIN-RESISTANCE SYNDROME; LOW-BIRTH-WEIGHT; BLOOD-PRESSURE; STRESS;
   MEN; GLUCOCORTICOIDS; POLYMORPHISMS; DISEASE; RISK; CBG
AB Variation in plasma levels of cortisol, an essential hormone in the stress response, is associated in population-based studies with cardio-metabolic, inflammatory and neuro-cognitive traits and diseases. Heritability of plasma cortisol is estimated at 30-60% but no common genetic contribution has been identified. The CORtisol NETwork (CORNET) consortium undertook genome wide association meta-analysis for plasma cortisol in 12,597 Caucasian participants, replicated in 2,795 participants. The results indicate that <1% of variance in plasma cortisol is accounted for by genetic variation in a single region of chromosome 14. This locus spans SERPINA6, encoding corticosteroid binding globulin (CBG, the major cortisol-binding protein in plasma), and SERPINA1, encoding alpha 1-antitrypsin (which inhibits cleavage of the reactive centre loop that releases cortisol from CBG). Three partially independent signals were identified within the region, represented by common SNPs; detailed biochemical investigation in a nested sub-cohort showed all these SNPs were associated with variation in total cortisol binding activity in plasma, but some variants influenced total CBG concentrations while the top hit (rs12589136) influenced the immunoreactivity of the reactive centre loop of CBG. Exome chip and 1000 Genomes imputation analysis of this locus in the CROATIA-Korcula cohort identified missense mutations in SERPINA6 and SERPINA1 that did not account for the effects of common variants. These findings reveal a novel common genetic source of variation in binding of cortisol by CBG, and reinforce the key role of CBG in determining plasma cortisol levels. In turn this genetic variation may contribute to cortisol-associated degenerative diseases.
C1 [Bolton, Jennifer L.; Anderson, Anna; Strachan, Mark W. J.; Reynolds, Rebecca M.; Walker, Brian R.] Univ Edinburgh, Queens Med Res Inst, Univ BHF Ctr Cardiovasc Sci, Edinburgh, Midlothian, Scotland.
   [Hayward, Caroline; Huffman, Jennifer; Wright, Alan; Hastie, Nicholas] Univ Edinburgh, Inst Genet & Mol Med, MRC, Human Genet Unit, Edinburgh, Midlothian, Scotland.
   [Direk, Nese; Velders, Fleur P.; Hofman, Albert; Uitterlinden, Andre G.; Tiemeier, Henning] Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands.
   [Lewis, John G.] Canterbury Hlth Labs, Christchurch, New Zealand.
   [Hammond, Geoffrey L.; Hill, Lesley A.] Univ British Columbia, Inst Life Sci, Dept Cellular & Physiol Sci, Vancouver, BC V5Z 1M9, Canada.
   [Wilson, James F.; Campbell, Harry; Rudan, Igor; Wild, Sarah H.; Price, Jackie F.] Univ Edinburgh, Ctr Populat Hlth Sci, Inst Genet & Mol Med, Edinburgh, Midlothian, Scotland.
   [Lahti, Jari; Raikkonen, Katri] Univ Helsinki, Inst Behav Sci, Helsinki, Finland.
   [Kajantie, Eero; Eriksson, Johan G.] Natl Inst Hlth & Welf, Helsinki, Finland.
   [Widen, Elisabeth; Palotie, Aarno] Univ Helsinki, Inst Mol Med Finland FIMM, Helsinki, Finland.
   [Palotie, Aarno] Univ Helsinki, Dept Med Genet, Helsinki, Finland.
   [Palotie, Aarno] Univ Cent Hosp, Helsinki, Finland.
   [Eriksson, Johan G.] Univ Helsinki, Dept Gen Practice & Primary Hlth Care, Helsinki, Finland.
   [Eriksson, Johan G.] Helsinki Univ Cent Hosp, Unit Gen Practice, Helsinki, Finland.
   [Eriksson, Johan G.] Folkhalsan Res Ctr, Helsinki, Finland.
   [Eriksson, Johan G.] Vasa Cent Hosp, Vaasa, Finland.
   [Kaakinen, Marika; Jarvelin, Marjo-Riitta] Univ Oulu, Inst Hlth Sci, Oulu, Finland.
   [Kaakinen, Marika; Jarvelin, Marjo-Riitta] Univ Oulu, Bioctr Oulu, Oulu, Finland.
   [Jarvelin, Marjo-Riitta] Natl Inst Hlth & Welf, Dept Children & Young People & Families, Oulu, Finland.
   [Jarvelin, Marjo-Riitta] Univ London Imperial Coll Sci Technol & Med, Dept Epidemiol & Biostat, MRC HPA Ctr Environm & Hlth, London, England.
   [Jarvelin, Marjo-Riitta] Oulu Univ Hosp, Unit Primary Care, Oulu, Finland.
   [Timpson, Nicholas J.; Smith, George Davey; Evans, David M.] Univ Bristol, Sch Social & Community Med, MRC Ctr Causal Analyses Translat Epidemiol, Bristol, Avon, England.
   [Ring, Susan M.; St Pourcain, Beate] Univ Bristol, Sch Social & Community Med, Bristol, Avon, England.
   [Tanaka, Toshiko; Milaneschi, Yuri; Ferrucci, Luigi] NIA, Longitudinal Studies Sect, Clin Res Branch, Baltimore, MD USA.
   [Milaneschi, Yuri] Vrije Univ Amsterdam, Dept Psychiat, Med Ctr, GGZ InGeest, Amsterdam, Netherlands.
   [Bandinelli, Stefania] ASF, Geriatr Unit, Florence, Italy.
   [van der Harst, Pim; Verweij, Niek] Univ Groningen, Univ Med Ctr Groningen, Dept Cardiol, Groningen, Netherlands.
   [van der Harst, Pim] Univ Groningen, Univ Med Ctr Groningen, Dept Genet, Groningen, Netherlands.
   [van der Harst, Pim] Durrer Ctr Cardiogenet Res, ICIN Netherlands Heart Inst, Utrecht, Netherlands.
   [Rosmalen, Judith G. M.] Univ Groningen, Univ Med Ctr Groningen, Groningen, Netherlands.
   [Bakker, Stephen J. L.; Dullaart, Robin P. F.] Univ Groningen, Univ Med Ctr Groningen, Dept Internal Med, Groningen, Netherlands.
   [Mahajan, Anubha; Lindgren, Cecilia M.; Morris, Andrew] Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.
   [Lind, Lars; Ingelsson, Erik] Uppsala Univ, Dept Med Sci, Uppsala, Sweden.
   [Anderson, Laura N.; Lye, Stephen J.] Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Toronto, ON M5G 1X5, Canada.
   [Pennell, Craig E.] Univ Western Australia, Sch Womens & Infants Hlth, Crawley, Australia.
   [Matthews, Stephen G.] Univ Toronto, Dept Physiol, Toronto, ON, Canada.
   [Eriksson, Joel; Mellstrom, Dan; Ohlsson, Claes] Univ Gothenburg, Sahlgrenska Acad, Inst Medicin, Ctr Bone & Arthrit Res, Gothenburg, Sweden.
C3 University of Edinburgh; University of Edinburgh; Erasmus University
   Rotterdam; Erasmus MC; Canterbury Health Laboratories; University of
   British Columbia; University of Edinburgh; University of Helsinki;
   Finland National Institute for Health & Welfare; University of Helsinki;
   University of Helsinki; University of Helsinki; Helsinki University
   Central Hospital; University of Helsinki; University of Helsinki;
   Helsinki University Central Hospital; Folkhalsan Research Center; Vaasa
   Central Hospital; University of Oulu; University of Oulu; Finland
   National Institute for Health & Welfare; Imperial College London;
   University of Oulu; University of Bristol; University of Bristol;
   National Institutes of Health (NIH) - USA; NIH National Institute on
   Aging (NIA); Vrije Universiteit Amsterdam; University of Groningen;
   University of Groningen; University of Groningen; University of
   Groningen; University of Oxford; Wellcome Centre for Human Genetics;
   Uppsala University; University of Toronto; Sinai Health System Toronto;
   Lunenfeld Tanenbaum Research Institute; University of Western Australia;
   University of Toronto; University of Gothenburg
RP Bolton, JL (corresponding author), Univ Edinburgh, Queens Med Res Inst, Univ BHF Ctr Cardiovasc Sci, Edinburgh, Midlothian, Scotland.
EM b.walker@ed.ac.uk
RI bandinelli, stefania/AAL-4570-2020; Pennell, Craig/ABD-6902-2020; Ring,
   Susan/AGU-3133-2022; Campbell, Harry/E-2959-2010; Gibbs, J.
   Raphael/A-3984-2010; St Pourcain, Beate/K-8004-2017; Ferrucci,
   Luigi/AED-9724-2022; Verweij, Niek/ABC-6249-2021; Rudan,
   Igor/JOJ-5671-2023; Morris, Andrew/C-2837-2009; Widén,
   Elisabeth/HMD-1188-2023; Lind, Lars/KAM-1968-2024; Tiemeier,
   Henning/H-6534-2019; Anderson, Laura/K-4707-2019; Wright,
   Alan/C-7782-2013; , Uitterlinden/AFV-9968-2022; Tanaka,
   Toshiko/HKW-0340-2023; Matthews, Stephen/N-7555-2018; Ohlsson,
   Claes/AGP-3544-2022; Lahti, Jari/P-2283-2019; Lye, Stephen/E-7269-2013;
   Wilson, James/A-5704-2009; Pennell, Craig/C-5190-2011; Ohlsson,
   Claes/HIR-6959-2022; Rosmalen, Judith/F-5375-2011; Bakker,
   Stephan/J-4023-2015; Rudan, Igor/I-1467-2012; Hayward,
   Caroline/M-8818-2016; Davey Smith, George/A-7407-2013; Timpson,
   Nicholas/O-7548-2015; Reynolds, Rebecca M/C-3044-2008; Direk,
   Nese/G-1746-2019; Evans, David/H-6325-2013; Lahti, Jari/P-7987-2018; van
   der Harst, Pim/HOH-5622-2023
OI Pennell, Craig/0000-0002-0937-6165; Venkatasubramanian,
   Siddharth/0000-0002-5860-0768; Anderson, Laura N./0000-0002-6106-5073;
   Milaneschi, Yuri/0000-0002-3697-6617; Ohlsson,
   Claes/0000-0002-9633-2805; Raikkonen, Katri/0000-0003-3124-3470;
   Rosmalen, Judith/0000-0002-6393-0032; Uitterlinden, Andre
   G/0000-0002-7276-3387; Bakker, Stephan/0000-0003-3356-6791; Rudan,
   Igor/0000-0001-6993-6884; Hammond, Geoffrey/0000-0002-4639-7336;
   Hayward, Caroline/0000-0002-9405-9550; Davey Smith,
   George/0000-0002-1407-8314; Tiemeier, Henning/0000-0002-4395-1397;
   Timpson, Nicholas/0000-0002-7141-9189; Reynolds, Rebecca
   M/0000-0001-6226-8270; s, hema/0000-0002-3440-9475; Lindgren,
   Cecilia/0000-0002-4903-9374; Matthews, Stephen/0000-0002-9654-9940;
   Verweij, Niek/0000-0002-4303-7685; Direk, Nese/0000-0002-3631-5990;
   Eriksson, Johan/0000-0002-2516-2060; Price, Jackie/0000-0003-3251-3970;
   Ferrucci, Luigi/0000-0002-6273-1613; St Pourcain,
   Beate/0000-0002-4680-3517; Evans, David/0000-0003-0663-4621; Kaakinen,
   Marika/0000-0002-9228-0462; Lahti, Jari/0000-0002-4310-5297; Mahajan,
   Anubha/0000-0001-5585-3420; Jarvelin, Marjo-Riitta/0000-0002-2149-0630;
   Lewis, John/0000-0003-2757-4111; Bandinelli,
   Stefania/0000-0002-6491-0850; Palotie, Aarno/0000-0002-2527-5874; van
   der Harst, Pim/0000-0002-2713-686X
FU Chief Scientist Office of the Scottish Government [CZB-4-733]; British
   Heart Foundation [RG11/4/28734]; Medical Research Council (UK); Republic
   of Croatia Ministry of Science, Education and Sports research grants
   [108-1080315-0302]; European Commission [LSHG-CT-2006-018947,
   QLK4-CT-2002-02528]; Chief Scientist Office of the Scottish Government;
   Royal Society; MRC Human Genetics Unit; Arthritis Research UK; European
   Union [LSHG-CT-2006-018947]; Research Institute for Diseases in the
   Elderly [014-93-015]; Netherlands Genomics Initiative/Netherlands
   Organisation for Scientific Research [050-060-810]; Erasmus MC; Erasmus
   University, Rotterdam; Netherlands Organization for the Health Research
   and Development; Ministry of Education, Culture and Science; Ministry
   for Health, Welfare and Sports; European Commission (Directorate-General
   XII); Municipality of Rotterdam; Netherlands Organization for the Health
   Research and Development [2009-017.106.370]; Netherlands Consortium for
   Healthy Ageing; Academy of Finland; Finnish Diabetes Research Society;
   Folkhalsan Research Foundation; Novo Nordisk Foundation; Finska
   Lakaresallskapet, Signe and Ane Gyllenberg Foundation; University of
   Helsinki; European Science Foundation (EUROSTRESS); Ministry of
   Education; Ahokas Foundation; Emil Aaltonen Foundation; Juho Vainio
   Foundation; Wellcome Trust [WT089062, 092731, WT098017, WT064890,
   WT090532]; Academy of Finland [104781, 120315, 129418]; Academy of
   Finland Center of Excellence in Complex Disease Genetics and Public
   Health Challenges Research Program (SALVE); University Hospital Oulu,
   Biocenter, University of Oulu, Finland [75617]; European Commission
   [EUROBLCS] [QLG1-CT-2000-01643]; National Heart, Lung and Blood
   Institute through the SNP Typing for Association [5R01HL087679-02];
   Multiple Phenotypes from Existing Epidemiologic Data (STAMPEED) program
   [1RL1MH083268-01]; National Institute of Health/The National Institute
   of Mental Health [5R01MH63706:02]; European Network of Genomic and
   Genetic Epidemiology (ENGAGE) project [HEALTH-F4-2007-201413]; Medical
   Research Council, UK [PrevMetSyn/Public Health Challenges Research
   Program (SALVE)] [G0500539, G0600705]; UK Medical Research Council;
   University of Bristol; Italian Ministry of Health; U.S. National
   Institute on Aging; Uppsala University; Uppsala University Hospital;
   Swedish Research Council; Swedish Heart-Lung Foundation; Dutch Kidney
   Foundation [E.033]; Groningen University Medical Center (Beleidsruimte);
   Bristol Myers Squibb; Dade Behring; Ausam; Roche; Abbott; The
   Netherlands Organization of Scientific Research; Dutch Heart Foundation;
   De Cock Foundation; UK Medical Research Council [G0500877]; National
   Health and Medical Research Council of Australia [353514, 572613,
   403981]; Canadian Institutes of Health Research [MOP82893]; University
   of Western Australia (UWA); Raine Medical Research Foundation; Telethon
   Institute for Child Health Research; UWA Faculty of Medicine, Dentistry
   and Health Sciences; Women and Infants Research Foundation; Curtin
   University; Swedish Foundation for Strategic Research; ALF/LUA research
   grant in Gothenburg; Lundberg Foundation; Torsten and Ragnar Soderber's
   Foundation; Petrus and Augusta Hedlunds Foundation; MRC [MC_UU_12013/1,
   G0500877, MC_UU_12013/4, G0600705, MC_UU_12013/3, MC_PC_U127561128]
   Funding Source: UKRI; Academy of Finland (AKA) [129418] Funding Source:
   Academy of Finland (AKA)
FX The CORtisol NETwork Consortium is funded by the Chief Scientist Office
   of the Scottish Government (grant CZB-4-733) and the British Heart
   Foundation (grant RG11/4/28734). The CROATIA-Vis, CROATIA-Korcula and
   CROATIA-Split studies were funded by grants from the Medical Research
   Council (UK), the Republic of Croatia Ministry of Science, Education and
   Sports research grants to IR (108-1080315-0302), and European Commission
   Framework 6 project EUROSPAN (Contract No. LSHG-CT-2006-018947). ORCADES
   was supported by the Chief Scientist Office of the Scottish Government,
   the Royal Society, the MRC Human Genetics Unit, Arthritis Research UK
   and the European Union framework program 6 EUROSPAN project (contract
   no. LSHG-CT-2006-018947). In the Rotterdam Study, the generation and
   management of genome-wide association study genotype data are supported
   by the Netherlands Organisation of Scientific Research Investments
   (number 175.010.2005.011, 911-03-012). This study is funded by the
   Research Institute for Diseases in the Elderly (014-93-015) and the
   Netherlands Genomics Initiative/Netherlands Organisation for Scientific
   Research project number 050-060-810. The Rotterdam Study is funded by
   Erasmus MC and Erasmus University, Rotterdam, the Netherlands
   Organization for the Health Research and Development, the Ministry of
   Education, Culture and Science, the Ministry for Health, Welfare and
   Sports, the European Commission (Directorate-General XII), and the
   Municipality of Rotterdam. HT was supported by the Vidi Grant of
   Netherlands Organization for the Health Research and Development
   (2009-017.106.370). ND was supported by the Netherlands Consortium for
   Healthy Ageing. The Helsinki Birth Cohort Study has been supported by
   grants from the Academy of Finland, the Finnish Diabetes Research
   Society, Folkhalsan Research Foundation, Novo Nordisk Foundation, Finska
   Lakaresallskapet, Signe and Ane Gyllenberg Foundation, University of
   Helsinki, European Science Foundation (EUROSTRESS), Ministry of
   Education, Ahokas Foundation, Emil Aaltonen Foundation, Juho Vainio
   Foundation, and Wellcome Trust (grant number WT089062). The Northern
   Finland Birth Cohort 1966 study is supported by the Academy of Finland
   [project grants 104781, 120315, 129418, Center of Excellence in Complex
   Disease Genetics and Public Health Challenges Research Program (SALVE)],
   University Hospital Oulu, Biocenter, University of Oulu, Finland
   (75617), the European Commission [EUROBLCS, Framework 5 award
   QLG1-CT-2000-01643], The National Heart, Lung and Blood Institute
   [5R01HL087679-02] through the SNP Typing for Association with Multiple
   Phenotypes from Existing Epidemiologic Data (STAMPEED) program
   [1RL1MH083268-01], The National Institute of Health/The National
   Institute of Mental Health [5R01MH63706:02], European Network of Genomic
   and Genetic Epidemiology (ENGAGE) project and grant agreement
   [HEALTH-F4-2007-201413], and the Medical Research Council, UK [G0500539,
   G0600705, PrevMetSyn/Public Health Challenges Research Program (SALVE)].
   ALSPAC was funded by the UK Medical Research Council and the Wellcome
   Trust (Grant ref: 092731) and the University of Bristol. The InCHIANTI
   study has been supported by the Italian Ministry of Health and the U.S.
   National Institute on Aging. The PIVUS study was supported by Wellcome
   Trust Grants WT098017, WT064890, WT090532, Uppsala University, Uppsala
   University Hospital, the Swedish Research Council and the Swedish
   Heart-Lung Foundation. The PREVEND Study has been supported by the Dutch
   Kidney Foundation (Grant E. 033), the Groningen University Medical
   Center (Beleidsruimte), Bristol Myers Squibb, Dade Behring, Ausam,
   Roche, Abbott, The Netherlands Organization of Scientific Research, The
   Dutch Heart Foundation, and the De Cock Foundation. The Edinburgh Type 2
   Diabetes Study was funded by the UK Medical Research Council (G0500877).
   For the Raine Study, this work was supported by funding for the 17 year
   follow-up and genotyping provided by the National Health and Medical
   Research Council of Australia (353514, 572613, 403981) and the Canadian
   Institutes of Health Research (MOP82893). Core funding for the Raine
   Study is provided by the University of Western Australia (UWA), Raine
   Medical Research Foundation, the Telethon Institute for Child Health
   Research, UWA Faculty of Medicine, Dentistry and Health Sciences, the
   Women and Infants Research Foundation and Curtin University. The
   MrOS-Sweden study was supported by the Swedish Research Council, the
   Swedish Foundation for Strategic Research, European Commission Grant
   QLK4-CT-2002-02528, the ALF/LUA research grant in Gothenburg, the
   Lundberg Foundation, the Torsten and Ragnar Soderber's Foundation,
   Petrus and Augusta Hedlunds Foundation, and the Novo Nordisk Foundation.
   The funders had no role in study design, data collection and analysis,
   decision to publish, or preparation of the manuscript.
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NR 52
TC 110
Z9 115
U1 1
U2 17
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1553-7404
J9 PLOS GENET
JI PLoS Genet.
PD JUL
PY 2014
VL 10
IS 7
AR e1004474
DI 10.1371/journal.pgen.1004474
PG 11
WC Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Genetics & Heredity
GA AM5ME
UT WOS:000339902600028
PM 25010111
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Castorena-Gonzalez, JA
   Kim, HJ
   Davis, MJ
AF Castorena-Gonzalez, Jorge A.
   Kim, Hae Jin
   Davis, Michael J.
TI Chronic metabolic stress impairs lymphatic contractility via activation
   of KATP channels in a mouse model of Type-2 diabetes
SO FRONTIERS IN PHYSIOLOGY
LA English
DT Article
DE lymphatic vessel; contractile dysfunction; db/db; lymphedema; KATP
ID CANCER-RELATED LYMPHEDEMA; RAT MODEL; OBESITY; SYSTEM; VALVES; FLOW
AB Introduction Chronic metabolic stress is a common underlying factor of multiple diseases, including obesity, type II diabetes, and metabolic syndrome. Lymphatic dysfunction, including valve defects, impaired contractile activity, and hyperpermeability, is also associated with these same diseases. We recently reported that acute metabolic stress leads to activation of KATP channels in lymphatic muscle cells, resulting in impairment of the intrinsic lymphatic pacemaker that drives their spontaneous contractions and active lymphatic pumping.Methods In the present study, we tested whether lymphatic contractile dysfunction occurs in the db/db mouse, a model of metabolic syndrome, and, if so, to what extent dysfunction might be mediated by KATP channel activation. Contractile function was assessed ex vivo in cannulated and pressurized popliteal collecting lymphatics from age-matched db/db mice or their BKS controls (from males and females at 18-20 weeks of age).Results Vessels from db/db mice exhibited pressure-dependent spontaneous contractions that were significantly reduced in amplitude, frequency, and calculated fractional pump flow at all tested pressures in the range 0.5 to 5 cmH2O, compared to BKS controls. The impaired contractile function of lymphatic vessels from db/db mice was improved by the KATP channel inhibitor glibenclamide (GLIB) at a concentration (1 mM) previously shown to have little or no off-target effects on lymphatic function. Because db/db mice are both obese and have elevated blood glucose levels, we tested whether elevated glucose per se altered contractile function. In glucose levels characteristic of diabetic animals (23 mM), the contraction frequency and fractional pump flow of lymphatic vessels from WT mice were significantly decreased compared to those observed in normal (5 mM) glucose concentrations. The equivalent concentration of mannitol, an osmotic control, did not result in any significant changes in lymphatic contractile function. Lymphatic dysfunction induced by high glucose was rescued by GLIB (1 mM), and lymphatic vessels from Kir6.1-/- mice were largely resistant to the inhibitory effects of high glucose.Discussion Our results suggest that a substantial fraction of lymphatic contractile impairment in db/db mice is mediated by the activation of KATP channels in lymphatic muscle cells, in part due to chronic metabolic stress associated with elevated glucose.
C1 [Castorena-Gonzalez, Jorge A.] Tulane Univ, Sch Med, Dept Pharmacol, New Orleans, LA USA.
   [Kim, Hae Jin; Davis, Michael J.] Univ Missouri, Sch Med, Dept Med Pharmacol & Physiol, Columbia, MO 65211 USA.
C3 Tulane University; University of Missouri System; University of Missouri
   Columbia
RP Davis, MJ (corresponding author), Univ Missouri, Sch Med, Dept Med Pharmacol & Physiol, Columbia, MO 65211 USA.
EM davismj@health.missouri.edu
FU National Institutes of Health (NIH) [NIH R01 HL-122578, R01-HL168568];
   National Research Foundation of Korea [NRF-2020R1A6A3A0303715]
FX The author(s) declare that financial support was received for the
   research and/or publication of this article. Research reported in this
   publication was supported by the National Institutes of Health (NIH)
   under award numbers: NIH R01 HL-122578 to MJD and R01-HL168568 to JAC-G.
   HJK was supported in part by grant NRF-2020R1A6A3A0303715 from the
   National Research Foundation of Korea.
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NR 47
TC 0
Z9 0
U1 0
U2 0
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1664-042X
J9 FRONT PHYSIOL
JI Front. Physiol.
PD APR 30
PY 2025
VL 16
AR 1558763
DI 10.3389/fphys.2025.1558763
PG 11
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA 2OB9P
UT WOS:001487253100001
PM 40370934
DA 2025-06-11
ER

PT J
AU Shaum, KM
   Polotsky, AJ
AF Shaum, Katherine M.
   Polotsky, Alex J.
TI Nutrition and reproduction: Is there evidence to support a "Fertility
   Diet" to improve mitochondrial function?
SO MATURITAS
LA English
DT Review
DE Nutrition; Fertility; Mitochondria; Obesity; Supplement
ID BODY-MASS INDEX; METABOLIC SYNDROME; OXIDATIVE STRESS; L-CARNITINE;
   OBESITY; SUPPLEMENTATION; PEROXIDATION; APOPTOSIS; QUALITY
AB Normal function of mitochondria plays an essential role in enabling reproductive capacity. To date, few studies have investigated the role of promoting mitochondrial health in relation to fertility in humans. Selected nutritional interventions have demonstrated a potential to enhance mitochondrial function, suggesting a promise for future research for fertility treatment. This review summarizes the extant literature and highlights a putative role of particular nutrients in promotion of mitochondrial function, including in vitro, animal and human studies. Strong basis exists to advocate for further investigation of nutritional treatments for infertility patients. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
C1 [Shaum, Katherine M.] Univ Colorado, Sch Med, Aurora, CO 80045 USA.
   [Polotsky, Alex J.] Univ Colorado, Dept Obstet & Gynecol, Sect Reprod Endocrinol & Infertil, Aurora, CO 80045 USA.
C3 University of Colorado System; University of Colorado Anschutz Medical
   Campus; University of Colorado System; University of Colorado Anschutz
   Medical Campus
RP Polotsky, AJ (corresponding author), Univ Colorado, Dept Obstet & Gynecol, Sect Reprod Endocrinol & Infertil, 12631 East 17th Ave,B-198-3 Aurora, Aurora, CO 80045 USA.
EM alex.polotsky@ucdenver.edu
FU NICHD NIH HHS [L50 HD069360] Funding Source: Medline
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NR 32
TC 5
Z9 5
U1 0
U2 40
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0378-5122
EI 1873-4111
J9 MATURITAS
JI Maturitas
PD APR
PY 2013
VL 74
IS 4
BP 309
EP 312
DI 10.1016/j.maturitas.2013.01.011
PG 4
WC Geriatrics & Gerontology; Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology; Obstetrics & Gynecology
GA 124II
UT WOS:000317456600004
PM 23376023
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Antoch, MP
   Chernov, MV
AF Antoch, Marina P.
   Chernov, Mikhail V.
TI Pharmacological modulators of the circadian clock as potential
   therapeutic drugs
SO MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
LA English
DT Article
DE Circadian clock; Genotoxic stress; CLOCK/BMAL1-mediated transcription;
   Pharmacological modulators; Chemical library; High throughput screening
ID GENE-EXPRESSION; MESSENGER-RNA; BRONCHIAL EPITHELIUM;
   PERIPHERAL-TISSUES; METABOLIC SYNDROME; MOUSE; TRANSCRIPTION; LIVER;
   TIME; BIOLOGY
AB Circadian clocks are molecular time-keeping systems that underlie daily fluctuations in multiple physiological and biochemical processes. It is well recognized now that dysfunctions of the circadian system (both genetically and environmentally induced) are associated with the development of various pathological conditions. Here we describe the application of high throughput screening approach designed to search for small molecules capable of pharmacological modulation of the molecular clock. We provide evidence for the feasibility and value of this approach for both scientific and therapeutic purposes. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Antoch, Marina P.] Roswell Pk Canc Inst, Dept Mol & Cellular Biol, Buffalo, NY 14263 USA.
   [Chernov, Mikhail V.] Roswell Pk Canc Inst, Dept Small Mol Screening Core, Buffalo, NY 14263 USA.
C3 Roswell Park Comprehensive Cancer Center; Roswell Park Comprehensive
   Cancer Center
RP Antoch, MP (corresponding author), Roswell Pk Canc Inst, Dept Mol & Cellular Biol, Buffalo, NY 14263 USA.
EM Marina.antoch@roswellpark.org
RI Chernov, Maksim/N-6628-2018
OI Antoch, mantoch/0000-0003-3001-8511
FU NIGMS;  [GM550926]
FX We thank Victoria Gorbacheva and Anatoly Prokvolit for technical help in
   chemical screening and Dmitry Gudkov for the editorial help.This work
   was supported by NIGMS grant GM550926 to M.P.A.
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NR 75
TC 8
Z9 8
U1 2
U2 5
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1383-5718
EI 1879-3592
J9 MUTAT RES-GEN TOX EN
JI Mutat. Res. Genet. Toxicol. Environ. Mutagen.
PD NOV-DEC
PY 2009
VL 680
IS 1-2
SI SI
BP 109
EP 115
DI 10.1016/j.mrgentox.2009.07.015
PG 7
WC Biotechnology & Applied Microbiology; Genetics & Heredity; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Genetics & Heredity; Toxicology
GA 534DK
UT WOS:000272875500018
PM 20336820
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Calvin, AD
   Somers, VK
AF Calvin, Andrew D.
   Somers, Virend K.
TI Obstructive sleep apnea and cardiovascular disease
SO CURRENT OPINION IN CARDIOLOGY
LA English
DT Review
DE cardiovascular outcomes; continuous positive airway pressure; sleep
   disordered breathing
ID POSITIVE AIRWAY PRESSURE; C-REACTIVE PROTEIN; PITUITARY-ADRENAL-AXIS;
   BLOOD-PRESSURE; RISK-FACTORS; CEREBROVASCULAR-DISEASE; METABOLIC
   SYNDROME; PLATELET-FUNCTION; OXIDATIVE STRESS; OBESE MEN
AB Purpose of review
   To update the reader on the most recent developments linking obstructive sleep apnea to cardiovascular disease
   Recent findings
   Significant progress has been made in defining the relationship between obstructive sleep apnea and cardiovascular disease. However, much work remains to be done to clarify the pathophysiologic mechanisms and the potential role of treatment of sleep apnea in the prevention of cardiovascular morbidity and mortality.
   Summary
   At present there is only limited evidence to recommend the routine treatment of obstructive sleep apnea specifically for the prevention of cardiovascular disease
C1 [Somers, Virend K.] Mayo Clin, Coll Med, Div Cardiovasc Dis & Internal Med, Rochester, MN 55905 USA.
   [Calvin, Andrew D.] Mayo Clin, Coll Med, Mayo Sch Grad Med Educ, Rochester, MN 55905 USA.
C3 Mayo Clinic; Mayo Clinic
RP Somers, VK (corresponding author), Mayo Clin, Coll Med, Div Cardiovasc Dis, 200 1st St SW, Rochester, MN 55905 USA.
RI Calvin, Andrew/MVT-9775-2025
OI Calvin, Andrew/0000-0002-0469-2847
FU Mayo Clinic Clinician-Investigator Training Program; Respironics
   Foundation; ResMed Foundation; Sorin Corporation
FX Funding support Andrew D Calvin is supported by the Mayo Clinic
   Clinician-Investigator Training ProgramDisclosures Dr Somers has served
   as a Consultant for Respironics, ResMed, Cardiac Concepts. Glaxo
   SmithKline, Sepracor and Medtronic Corporation and has been a principal
   investigator or co-investigator on research grants funded by the
   Respironics Foundation, the ResMed Foundation and the Sorin Corporation
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NR 51
TC 10
Z9 10
U1 0
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0268-4705
EI 1531-7080
J9 CURR OPIN CARDIOL
JI Curr. Opin. Cardiol.
PD NOV
PY 2009
VL 24
IS 6
BP 516
EP 520
DI 10.1097/HCO.0b013e328330c2ed
PG 5
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 510UV
UT WOS:000271119100002
PM 19644364
DA 2025-06-11
ER

PT J
AU Pan, A
   Ye, XW
   Franco, OH
   Li, HX
   Yu, ZJ
   Wang, J
   Qi, QB
   Gu, WJ
   Pang, XH
   Liu, H
   Lin, X
AF Pan, An
   Ye, Xingwang
   Franco, Oscar H.
   Li, Huaixing
   Yu, Zhijie
   Wang, Jing
   Qi, Qibin
   Gu, Wenjia
   Pang, Xinghuo
   Liu, Hong
   Lin, Xu
TI The Association of Depressive Symptoms with Inflammatory Factors and
   Adipokines in Middle-Aged and Older Chinese
SO PLOS ONE
LA English
DT Article
ID C-REACTIVE PROTEIN; CORONARY-HEART-DISEASE; ADIPOSE-TISSUE;
   CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; RISK-FACTORS; OBESITY;
   MARKERS; HEALTH; MOOD
AB Background. Studies in Western populations find that depression is associated with inflammation and obesity. The present study aimed to evaluate the relation of depressive symptoms with inflammatory factors and adipose-derived adipokines in middle-aged and older Chinese. Methodology/Principal Findings. Data were from 3289 community residents aged 50-70 from Beijing and Shanghai who participated in the Nutrition and Health of Aging Population in China project. Depressive symptoms were defined as a Center for Epidemiological Studies of Depression Scale (CES-D) score of 16 or higher. Plasma concentrations of C-reactive protein (CRP), interleukin-6 (IL-6), adiponectin, resistin, plasminogen activator inhibitor-1 (PAI-1) and retinol binding protein 4 (RBP4) were measured. Of the 3289 participants, 312 (9.5%) suffered from current depressive symptoms. IL-6 level was higher in participants with depressive symptoms compared to their counterparts in the crude analyses (1.17 vs. 1.05 pg/mL, p = 0.023) and this association lost statistical significance after multiple adjustments (1.13 vs. 1.10 pg/mL, p = 0.520). Depressive symptoms were not associated with increased mean levels of any other inflammatory factors or adipokines in the unadjusted or adjusted analyses. Conclusions/Significance. We found no evidence that depressive symptoms were associated with inflammatory factors and adipokines in the middle-aged and older Chinese populations. Prospective studies and studies in clinically diagnosed patients are needed to confirm our results and clarify the relation of depression with inflammatory factors and adipokines.
C1 [Pan, An; Ye, Xingwang; Li, Huaixing; Yu, Zhijie; Wang, Jing; Qi, Qibin; Gu, Wenjia; Lin, Xu] Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Key Lab Syst Biol, Shanghai, Peoples R China.
   [Franco, Oscar H.] Unilever Corp Res, Colworth House, Sharnbrook, Beds, England.
   [Pang, Xinghuo] Beijing Ctr Dis Control & Prevent, Beijing, Peoples R China.
   [Liu, Hong] Shanghai Ctr Dis Control & Prevent, Shanghai, Peoples R China.
C3 Chinese Academy of Sciences; Unilever; Shanghai Center for Disease
   Control & Prevention
RP Lin, X (corresponding author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Key Lab Syst Biol, Shanghai, Peoples R China.
EM xlin@sibs.ac.cn
RI Qi, Qibin/H-9055-2012; Ye, Xingwang/D-5193-2011; Yu,
   Zhijie/AFT-1125-2022; lin, xu/KOC-3517-2024; Franco,
   Óscar/ABE-2305-2020; Li, Xiaoying/GYA-2677-2022; Pan, An/C-5572-2011
OI Franco, Oscar/0000-0002-4606-4929; Pan, An/0000-0002-1089-7945
FU Chinese Academy of Sciences; Shanghai-Unilever Research Development
   Fund; Science and Technology Commission of Shanghai Municipality;
   Ministry of Science and Technology of China;  [KSCX2-2-25];  [200306]; 
   [04DZ14007];  [2006CB503900]
FX This study was funded by Grants KSCX2-2-25, 200306, 04DZ14007 and 973
   Program 2006CB503900 from the Chinese Academy of Sciences, the
   Shanghai-Unilever Research Development Fund, the Science and Technology
   Commission of Shanghai Municipality, and the Ministry of Science and
   Technology of China, respectively. None of the funding sources had any
   role in the collection of data, interpretation of results, or
   preparation of this manuscript.
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NR 51
TC 57
Z9 58
U1 1
U2 13
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JAN 2
PY 2008
VL 3
IS 1
AR e1392
DI 10.1371/journal.pone.0001392
PG 6
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Science & Technology - Other Topics
GA 366GP
UT WOS:000260468900020
PM 18167551
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Lonardo, F
   Ballouk, C
AF Lonardo, Fulvio
   Ballouk, Casem
TI Metabolism and cancer-select topics
SO METABOLISM AND TARGET ORGAN DAMAGE
LA English
DT Review
DE Cancer; metabolism; type 2 diabetes Mellitus (T2DM); obesity
ID BODY-MASS INDEX; TYPE-2 DIABETES-MELLITUS; PLASMA ADIPONECTIN LEVELS;
   PHYSICAL-ACTIVITY; PROSTATE-CANCER; HIGH GLUCOSE; ENERGY-EXPENDITURE;
   COLORECTAL-CANCER; LUNG-CANCER; CALORIC RESTRICTION
AB Metabolism and cancer intersect in multiple ways. Cancer has unique metabolic properties, including an inordinate reliance on anaerobic glycolysis (the Warburg effect). From an evolutionary standpoint, increased cancer incidence is associated with increased metabolic rates across species. Epidemiological data prove that a group of overlapping metabolic alterations, including obesity, type 2 diabetes Mellitus, nonalcoholic fatty liver disease, and metabolic syndrome, constitute predisposing risk factors for cancer development in multiple anatomical sites. The molecular pathways underpinning this association involve hyperinsulinemia, hyperglycemia, sex hormones, adipokines, chronic inflammation, oxidative stress, and altered immune response.
C1 [Lonardo, Fulvio; Ballouk, Casem] Wayne State Univ, Harper Univ Hosp, Sch Med, Dept Pathol, 3990 John R St Detroit, Detroit, MI 48201 USA.
   [Lonardo, Fulvio] Karmanos Canc Inst, 3990 John R St Detroit, Detroit, MI 48201 USA.
C3 Wayne State University; Barbara Ann Karmanos Cancer Institute
RP Lonardo, F (corresponding author), Wayne State Univ, Harper Univ Hosp, Sch Med, Dept Pathol, 3990 John R St Detroit, Detroit, MI 48201 USA.; Lonardo, F (corresponding author), Karmanos Canc Inst, 3990 John R St Detroit, Detroit, MI 48201 USA.
EM flonardo@med.wayne.edu
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NR 153
TC 6
Z9 6
U1 1
U2 1
PU OAE PUBLISHING INC
PI ALHAMBRA
PA 245 E MAIN ST, ST122, ALHAMBRA, CA 91801 USA
EI 2769-6375
J9 METAB TARGET ORGAN D
JI Metab. Target Organ Damage
PD JUN
PY 2022
VL 2
IS 2
AR 8
DI 10.20517/mtod.2022.05
PG 15
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA I6L8O
UT WOS:001331363400001
OA gold
DA 2025-06-11
ER

PT J
AU Knez, M
   Glibetic, M
AF Knez, Marija
   Glibetic, Maria
TI Zinc as a Biomarker of Cardiovascular Health
SO FRONTIERS IN NUTRITION
LA English
DT Review
DE zinc; cardiovascular diseases; zinc deficiency; zinc supplementation;
   obesity; hypertension; cardiovascular health
ID TRANSPORTER-8 GENE SLC30A8; SERUM ZINC; INSULIN-RESISTANCE; METABOLIC
   SYNDROME; TRACE-ELEMENTS; ENDOTHELIAL DYSFUNCTION; PREDICT MORTALITY;
   DIABETES-MELLITUS; OXIDATIVE STRESS; GLYCEMIC CONTROL
AB The importance of zinc (Zn) for cardiovascular health continuously gains recognition. As shown earlier, compromised Zn homeostasis and prolonged inflammation are common features in various cardiovascular diseases (CVDs). Similarly, Zn biochemistry alters several vascular processes, and Zn status is an important feature of cardiovascular health. Zn deficiency contributes to the development of CVDs; thus, Zn manipulations, including Zn supplementation, are beneficial for preventing and treating numerous cardiovascular (CV) disorders. Finally, additional long-term, well-designed studies, performed in various population groups, should be pursued to further clarify significant relationships between Zn and CVDs.
C1 [Knez, Marija; Glibetic, Maria] Univ Belgrade, Natl Inst Med Res, Ctr Res Excellence Nutr & Metab, Belgrade, Serbia.
C3 University of Belgrade
RP Knez, M (corresponding author), Univ Belgrade, Natl Inst Med Res, Ctr Res Excellence Nutr & Metab, Belgrade, Serbia.
EM marijaknez186@gmail.com
RI Knez, Marija/IXW-5676-2023
FU Ministry of Education, Science and Technological Development of the
   Republic of Serbia [451-03-9/2021-14/200015]
FX This work was supported by the Ministry of Education, Science and
   Technological Development of the Republic of Serbia, Contract
   451-03-9/2021-14/200015.
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NR 88
TC 35
Z9 35
U1 4
U2 29
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD JUL 30
PY 2021
VL 8
AR 686078
DI 10.3389/fnut.2021.686078
PG 7
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA UA5YH
UT WOS:000685236900001
PM 34395491
OA Green Published, gold
DA 2025-06-11
ER

PT S
AU Daniel, M
   Lekkas, P
   Cargo, M
   Stankov, I
   Brown, A
AF Daniel, Mark
   Lekkas, Peter
   Cargo, Margaret
   Stankov, Ivana
   Brown, Alex
BE Fielding, JE
   Brownson, RC
   Green, LW
TI Environmental Risk Conditions and Pathways to Cardiometabolic Diseases
   in Indigenous Populations
SO ANNUAL REVIEW OF PUBLIC HEALTH, VOL 32
SE Annual Review of Public Health
LA English
DT Review; Book Chapter
DE aboriginal; cardiovascular diseases; diabetes mellitus; population
   health; composition versus context
ID 1ST NATIONS PEOPLES; CARDIOVASCULAR-DISEASE; AMERICAN-INDIANS;
   PARTICIPATORY RESEARCH; NORTHERN-TERRITORY; PHYSICAL-ACTIVITY;
   HEALTH-PROMOTION; NEW-ZEALAND; RACIAL-DISCRIMINATION; ABORIGINAL
   POPULATION
AB This review examines environments in relation to cardiornetabolic diseases in Indigenous populations in developed countries. Environmental factors are framed in terms of context (features of places) and composition (features of populations). Indigenous peoples are seen to have endured sociopolitical marginalization and material disadvantage spanning generations. Past adverse collective experiences, modified by culture, are reflected by current heterogeneity in environmental context and composition. As risk conditions, unfavorable contextual and compositional exposures influence the expression of cardiometabolic risk for individuals. Minimal research has evaluated heterogeneity in risk conditions against heterogeneity in cardiometabolic diseases between or within Indigenous populations. Thus far, the features of populations, not of places themselves, have been implicated in relation to cardiometabolic diseases. Behavioral, psychosocial, and stress-axis pathways may explain the relationships between risk conditions and cardiometabolic diseases. Implications of environmental factors and their pathways as well as important research needs are discussed in relation to ecological prevention to reduce cardiometabolic diseases.
C1 [Daniel, Mark; Lekkas, Peter; Cargo, Margaret; Stankov, Ivana] Univ S Australia, Social Epidemiol & Evaluat Res Unit, Sansom Inst Hlth Res, Adelaide, SA 5001, Australia.
   [Daniel, Mark] Univ Melbourne, Dept Med, St Vincents Hosp, Fitzroy, Vic 3065, Australia.
   [Brown, Alex] Ctr Indigenous Vasc & Diabet Res, Baker IDI Heart & Diabet Inst, Alice Springs, NT 0870, Australia.
C3 University of South Australia; University of Melbourne; St Vincent's
   Health; St Vincent's Hospital Melbourne; NSW Health; St Vincents
   Hospital Sydney; Baker Heart and Diabetes Institute
RP Daniel, M (corresponding author), Univ S Australia, Social Epidemiol & Evaluat Res Unit, Sansom Inst Hlth Res, Adelaide, SA 5001, Australia.
EM mark.daniel@unisa.edu.au; peter.lekkas@unisa.edu.au;
   margaret.cargo@unisa.edu.au; ivana.stankov@gmail.com;
   alex.brown@bakeridi.edu.au
RI Stankov, Ivana/MFH-6678-2025; Brown, Alex/E-8614-2010; Daniel,
   Mark/A-1151-2009; Cargo, Margaret/B-2141-2010
OI Daniel, Mark/0000-0001-9112-134X; Stankov, Ivana/0000-0002-9232-2749;
   Lekkas, Peter/0009-0008-1057-8494; Brown, Alex/0000-0003-2112-3918
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NR 146
TC 32
Z9 35
U1 0
U2 26
PU ANNUAL REVIEWS
PI PALO ALTO
PA 4139 EL CAMINO WAY, PO BOX 10139, PALO ALTO, CA 94303-0897 USA
SN 0163-7525
BN 978-0-8243-2732-3
J9 ANNU REV PUBL HEALTH
JI Annu. Rev. Public Health
PY 2011
VL 32
BP 327
EP 347
DI 10.1146/annurev.publhealth.012809.103557
PG 21
WC Public, Environmental & Occupational Health
WE Book Citation Index – Social Sciences & Humanities (BKCI-SSH); Book Citation Index – Science (BKCI-S); Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA BUZ33
UT WOS:000290776200018
PM 21219157
DA 2025-06-11
ER

PT J
AU Delker, E
   AlYami, B
   Gallo, LC
   Ruiz, JM
   Szklo, M
   Allison, MA
AF Delker, Erin
   AlYami, Bandar
   Gallo, Linda C.
   Ruiz, John M.
   Szklo, Moyses
   Allison, Matthew A.
TI Chronic Stress Burden, Visceral Adipose Tissue, and Adiposity-Related
   Inflammation: The Multi-Ethnic Study of Atherosclerosis
SO PSYCHOSOMATIC MEDICINE
LA English
DT Article
DE visceral adipose tissue; central adiposity; inflammation; chronic
   psychosocial stress
ID MECHANISMS LINKING OBESITY; BODY-MASS INDEX; PSYCHOSOCIAL STRESS;
   DEPRESSIVE SYMPTOMS; INSULIN-RESISTANCE; METABOLIC SYNDROME; HAIR
   CORTISOL; ASSOCIATIONS; FAT; RISK
AB Objective: We investigated the role of chronic stress burden on adiposity and adiposity-related inflammation with two hypotheses: a) greater chronic stress is associated with higher central adiposity and selective accumulation of visceral adipose tissue (VAT) compared with subcutaneous adipose tissue (SAT), and b) associations between VAT and inflammatory biomarkers are exacerbated when chronic stress is high.
   Methods: Data come from 1809 participants included in a Multi-Ethnic Study of Atherosclerosis ancillary study of body composition and adiposity-related inflammation. Chronic psychosocial stress was measured with a five-item version of the Chronic Stress Burden Scale. First, we tested associations between chronic stress (three-level categorical variable) and VAT, SAT, and VAT/SAT ratio. Second, we tested whether associations between VAT and inflammatory biomarkers varied by level of chronic stress.
   Results: Participants were approximately 65 years, 50% female, and 40.5% White, 25.6% Hispanic, 21.2% African American, and 12.8% Chinese American. About half of the sample reported little to no stress, and a quarter and a fifth of the sample reported medium and high levels of stress. Higher levels of chronic stress were associated with greater VAT and SAT, but not VAT/SAT ratio. Greater levels of VAT were associated with increased levels of adiposity-related inflammation in a graded pattern. These associations did not vary by stress level.
   Conclusions: Greater chronic stress burden is associated with both central and subcutaneous adiposity. We found no evidence that the associations between VAT and inflammatory biomarkers are exacerbated by chronic stress. Findings contribute to ongoing literature untangling pathways in which psychosocial stress contributes to adiposity-related inflammation.
C1 [Delker, Erin] San Diego State Univ, Joint Doctoral Program Epidemiol, San Diego, CA 92182 USA.
   [Delker, Erin] Univ Calif San Diego, San Diego, CA 92103 USA.
   [AlYami, Bandar] Univ Calif San Diego, Sch Med, San Diego, CA 92103 USA.
   [Gallo, Linda C.] San Diego State Univ, Dept Psychol, San Diego, CA 92182 USA.
   [Ruiz, John M.] Univ Arizona, Dept Psychol, Tucson, AZ 85721 USA.
   [Szklo, Moyses] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA.
   [Allison, Matthew A.] Univ Calif San Diego, Family Med & Publ Hlth, San Diego, CA 92103 USA.
C3 California State University System; San Diego State University;
   University of California System; University of California San Diego;
   University of California System; University of California San Diego;
   California State University System; San Diego State University;
   University of Arizona; Johns Hopkins University; Johns Hopkins Bloomberg
   School of Public Health; University of California System; University of
   California San Diego
RP Delker, E (corresponding author), Univ Calif San Diego, Family Med & Publ Hlth, 9500 Gilman Dr,Mail Code 0965, La Jolla, CA 92093 USA.
EM emdelker@health.ucsd.edu
OI Alyami, Bandar/0000-0002-9048-0620
FU National Heart, Lung, and Blood Institute [75N92020D00001,
   HHSN268201500003I, N01-HC-95159, 75N92020D00005, N01-HC-95160,
   75N92020D00002, N01-HC-95161, 75N92020D00003, N01-HC-95162,
   75N92020D00006, N01-HC-95163, 75N92020D00004, N01-HC-95164,
   75N92020D00007]; National Center for Advancing Translational Sciences
   [UL1-TR-000040, UL1-TR-001079, UL1-TR-001420]; the National Heart, Lung,
   and Blood Institute [R01HL088541, T32-HL079891-13, N01-HC-95165,
   N01-HC-95166, N01-HC-95167, N01-HC-95168, N01-HC-95169]
FX This research was supported by contracts 75N92020D00001,
   HHSN268201500003I, N01-HC-95159, 75N92020D00005, N01-HC-95160,
   75N92020D00002, N01-HC-95161, 75N92020D00003, N01-HC-95162,
   75N92020D00006, N01-HC-95163, 75N92020D00004, N01-HC-95164,
   75N92020D00007, N01-HC-95165, N01-HC-95166, N01-HC-95167, N01-HC-95168,
   and N01-HC-95169 from the National Heart, Lung, and Blood Institute, and
   by grants UL1-TR-000040, UL1-TR-001079, and UL1-TR-001420 from the
   National Center for Advancing Translational Sciences. Reading of the
   computed tomography scans was funded by the National Heart, Lung, and
   Blood Institute (R01HL088541). The authors thank the other
   investigators, the staff, and the participants of theMESA study for
   their valuable contributions. A full list of participating MESA
   investigators and institutions can be found at
   http://www.mesa-nhlbi.org. E. Delker was supported byNational Heart,
   Lung, and Blood Institute (T32-HL079891-13). Authors report no conflicts
   of interest.
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NR 48
TC 10
Z9 11
U1 3
U2 10
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0033-3174
EI 1534-7796
J9 PSYCHOSOM MED
JI Psychosom. Med.
PD OCT
PY 2021
VL 83
IS 8
BP 834
EP 842
DI 10.1097/PSY.0000000000000983
PG 9
WC Psychiatry; Psychology; Psychology, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry; Psychology
GA ZA4WR
UT WOS:000756166300002
PM 34292207
OA Green Accepted, Green Submitted
DA 2025-06-11
ER

PT J
AU Chen, TY
   Dalton, G
   Oh, SH
   Maeso-Diaz, R
   Du, K
   Meyers, RA
   Guy, C
   Abdelmalek, MF
   Henao, R
   Guarnieri, P
   Pullen, SS
   Gregory, S
   Locker, J
   Brown, JM
   Diehl, AM
AF Chen, Tianyi
   Dalton, George
   Oh, Seh-Hoon
   Maeso-Diaz, Raquel
   Du, Kuo
   Meyers, Rachel A.
   Guy, Cynthia
   Abdelmalek, Manal F.
   Henao, Ricardo
   Guarnieri, Paolo
   Pullen, Steven S.
   Gregory, Simon
   Locker, Joseph
   Brown, J. Mark
   Diehl, Anna Mae
TI Hepatocyte Smoothened Activity Controls Susceptibility to Insulin
   Resistance and Nonalcoholic Fatty Liver Disease
SO CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
LA English
DT Article
DE hedgehog; nonalcoholic fatty liver disease; metabolic syndrome
ID METABOLIC-REGULATION; SIGNALING PATHWAY; ROR-ALPHA; HEDGEHOG; PROTEIN;
   PROGRESSION; BINDING; GROWTH; GLUCONEOGENESIS; DYSFUNCTION
AB BACKGROUND & AIMS: Nonalcoholic steatohepatitis (NASH), a leading cause of cirrhosis, strongly associates with the meta-bolic syndrome, an insulin-resistant proinflammatory state that disrupts energy balance and promotes progressive liver degeneration. We aimed to define the role of Smoothened (Smo), an obligatory component of the Hedgehog signaling pathway, in controlling hepatocyte metabolic homeostasis and, thereby, susceptibility to NASH. METHODS: We conditionally deleted Smo in hepatocytes of healthy chow-fed mice and performed metabolic phenotyping, hepatocyte Hedgehog activity induces hepatic and systemic metabolic stress and enhances susceptibility to NASH by pro-moting hepatic lipoxicity and insulin resistance.
C1 [Chen, Tianyi; Dalton, George; Oh, Seh-Hoon; Maeso-Diaz, Raquel; Du, Kuo; Meyers, Rachel A.; Guy, Cynthia; Abdelmalek, Manal F.; Henao, Ricardo; Gregory, Simon; Diehl, Anna Mae] Duke Univ, Dept Med, Durham, NC USA.
   [Guarnieri, Paolo; Pullen, Steven S.] Boehringer Ingelheim Pharmaceut Inc, Ridgefield, CT USA.
   [Locker, Joseph] Univ Pittsburgh, Dept Pathol, Pittsburgh, PA USA.
   [Brown, J. Mark] Cleveland Clin, Dept Cardiovasc & Metab Sci, Lerner Res Inst, Cleveland Hts, OH USA.
   [Diehl, Anna Mae] Duke Univ, Genome Sci Res Bldg-1, Suite 1073, Box 3256, Res D, Durham, NC 27710 USA.
C3 Duke University; Boehringer Ingelheim; Pennsylvania Commonwealth System
   of Higher Education (PCSHE); University of Pittsburgh; Cleveland Clinic
   Foundation; Duke University
RP Diehl, AM (corresponding author), Duke Univ, Genome Sci Res Bldg-1, Suite 1073, Box 3256, Res D, Durham, NC 27710 USA.
EM annamae.diehl@duke.edu
RI Abdelmalek, Manal/AAW-2203-2020; Henao, Ricardo/Q-1381-2016
OI Locker, Joseph/0000-0002-4190-188X
FU National Institutes of Health [RO1 DK 077794]; Duke Endowment; NAFLD
   Clinical Research Program Discretionary Funds - Boehringer Ingelheim
   Pharmaceuticals
FX Funding Anna Mae Diehl was supported by National Institutes of Health
   grant RO1 DK 077794 and the Duke Endowment. Manal F. Abdelmalek was
   supported by NAFLD Clinical Research Program Discretionary Funds. This
   study was funded by Boehringer Ingelheim Pharmaceuticals.
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NR 117
TC 17
Z9 17
U1 2
U2 8
PU ELSEVIER INC
PI SAN DIEGO
PA 525 B STREET, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 2352-345X
J9 CELL MOL GASTROENTER
JI Cell. Mol. Gastroenterol. Hepatol.
PY 2023
VL 15
IS 4
BP 949
EP 970
DI 10.1016/j.jcmgh.2022.12.008
EA FEB 2023
PG 22
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 9Z9TM
UT WOS:000951474800001
PM 36535507
OA Green Published
DA 2025-06-11
ER

PT J
AU Orchard, TJ
   Costacou, T
AF Orchard, Trevor J.
   Costacou, Tina
TI When Are Type 1 Diabetic Patients at Risk for Cardiovascular Disease?
SO CURRENT DIABETES REPORTS
LA English
DT Article
DE Type 1 diabetes; Cardiovascular disease risk; Risk factors; Glycemia;
   Haptoglobin
ID CORONARY-ARTERY-DISEASE; MEDIATED OXIDATIVE STRESS; VITAMIN-E
   SUPPLEMENTATION; HAPTOGLOBIN GENOTYPE; PITTSBURGH EPIDEMIOLOGY;
   ENDOTHELIAL DYSFUNCTION; METABOLIC SYNDROME; INDIVIDUALS; MORTALITY;
   NEPHROPATHY
AB This discussion of increased cardiovascular risk in patients with type 1 diabetes reviews recent data concerning glycemia and the role of glycemic control in type 1 diabetes, as well as observations of an association with haptoglobin genotype and coronary artery disease events. This genetic predisposition also leads to oxidative damage and appears to be associated with profound high-density lipoprotein dysfunction. This article also briefly discusses recent data on general cardiovascular risk factors and provides updated comments concerning the association of coronary artery disease with other diabetes complications, especially renal disease.
C1 [Orchard, Trevor J.; Costacou, Tina] Univ Pittsburgh, Dept Epidemiol, Pittsburgh, PA 15213 USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE); University
   of Pittsburgh
RP Orchard, TJ (corresponding author), Univ Pittsburgh, Dept Epidemiol, 3512 5th Ave, Pittsburgh, PA 15213 USA.
EM orchardt@edc.pitt.edu
OI orchard, trevor/0000-0001-9552-3215
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U1 0
U2 4
PU CURRENT MEDICINE GROUP
PI PHILADELPHIA
PA 400 MARKET STREET, STE 700, PHILADELPHIA, PA 19106 USA
SN 1534-4827
EI 1539-0829
J9 CURR DIABETES REP
JI Curr. Diabetes Rep.
PD FEB
PY 2010
VL 10
IS 1
BP 48
EP 54
DI 10.1007/s11892-009-0089-3
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 555IA
UT WOS:000274501300008
PM 20425067
DA 2025-06-11
ER

PT J
AU Cataldo, I
   Maggio, A
   Gena, P
   de Bari, O
   Tamma, G
   Portincasa, P
   Calamita, G
AF Cataldo, Ilaria
   Maggio, Anna
   Gena, Patrizia
   de Bari, Ornella
   Tamma, Grazia
   Portincasa, Piero
   Calamita, Giuseppe
TI Modulation of Aquaporins by Dietary Patterns and Plant Bioactive
   Compounds
SO CURRENT MEDICINAL CHEMISTRY
LA English
DT Review
DE Nutraceuticals; polyphenols; functional food; metabolic syndrome; gut
   microbiota; aquaporins
ID FATTY LIVER-DISEASE; SPINAL-CORD-INJURY; INSULIN-RESISTANCE; MOLECULAR
   CHARACTERIZATION; APPLE POLYPHENOL; UREA TRANSPORTER; OXIDATIVE STRESS;
   GENE-EXPRESSION; DOWN-REGULATION; WATER CHANNELS
AB Healthful dietary patterns and bioactive compounds supplementation can be adopted as simple and easy intervention to prevent, attenuate or cure clinical disorders, especially when it comes to degenerative and chronic diseases. In the recent years, a growing body of evidence indicates Aquaporins (AQPs), a family of membrane channel proteins widely expressed in the human body, among the targets underlying the beneficial action played by some food nutrients and phytochemical compounds. Here, we provide an overview of what is known regarding the AQP modulation exerted by healthful dietary patterns and plant polyphenols.
C1 [Cataldo, Ilaria; Maggio, Anna; Gena, Patrizia; Tamma, Grazia; Calamita, Giuseppe] Univ Bari Aldo Moro, Med Sch, Dept Biosci Biotechnol & Biopharmaceut, Bari, Italy.
   [de Bari, Ornella; Portincasa, Piero] Univ Bari Aldo Moro, Med Sch, Dept Biomed Sci & Human Oncol, Clin Med A Murri, Bari, Italy.
C3 Universita degli Studi di Bari Aldo Moro; Universita degli Studi di Bari
   Aldo Moro
RP Calamita, G (corresponding author), Univ Bari Aldo Moro, Dipartimento Biosci Biotecnol & Biofarmaceut, Via E Orabona, I-70125 Bari, Italy.
EM giuseppe.calamita@uniba.it
RI Gena, patrizia/AAC-3396-2022; Tamma, Grazia/F-8823-2016; portincasa,
   piero/J-7245-2018
FU Regione Puglia (Rete di Laboratori Pubblici di Ricerca WAFITECH) [09];
   National Institutes of Health Research (NIHR) [09] Funding Source:
   National Institutes of Health Research (NIHR)
FX Financial support is gratefully acknowledged by grant from Regione
   Puglia (Rete di Laboratori Pubblici di Ricerca WAFITECH - cod. 09) to
   G.C.
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NR 83
TC 8
Z9 8
U1 1
U2 22
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 0929-8673
EI 1875-533X
J9 CURR MED CHEM
JI Curr. Med. Chem.
PY 2019
VL 26
IS 19
BP 3457
EP 3470
DI 10.2174/0929867324666170523123010
PG 14
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Pharmacology &
   Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
GA IX6HC
UT WOS:000485782800006
PM 28545373
DA 2025-06-11
ER

PT J
AU Gohar, A
   de Kleijn, DPV
   Hoes, AW
   Rutten, FH
   Hilfiker-Kleiner, D
   Ferdinandy, P
   Sluijter, JPG
   den Ruijter, HM
AF Gohar, Aisha
   de Kleijn, Dominique P. V.
   Hoes, Arno W.
   Rutten, Frans H.
   Hilfiker-Kleiner, Denise
   Ferdinandy, Peter
   Sluijter, Joost P. G.
   den Ruijter, Hester M.
TI Vascular extracellular vesicles in comorbidities of heart failure with
   preserved ejection fraction in men and women: The hidden players. A mini
   review
SO VASCULAR PHARMACOLOGY
LA English
DT Review
DE Endothelial microparticles; HFpEF; LVD; Sex; Comorbidities
ID CIRCULATING ENDOTHELIAL MICROPARTICLES; METABOLIC SYNDROME;
   ATRIAL-FIBRILLATION; DIASTOLIC DYSFUNCTION; BLOOD MICROPARTICLES;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; NITRIC-OXIDE; RISK; PREECLAMPSIA
AB Left ventricular diastolic dysfunction, the main feature of heart failure with preserved ejection fraction (HFpEF), is thought to be primarily caused by comorbidities affecting the endothelial function of the coronary microvasculature. Circulating extracellular vesicles, released by the endothelium have been postulated to reflect endothelial damage. Therefore, we reviewed the role of extracellular vesicles, in particularly endothelium microparticles, in these comorbidities, including obesity and hypertension, to identify if they may be potential markers of the endothelial dysfunction underlying left ventricular diastolic dysfunction and HFpEF.
C1 [Gohar, Aisha; de Kleijn, Dominique P. V.; Sluijter, Joost P. G.; den Ruijter, Hester M.] Univ Utrecht, Univ Med Ctr Utrecht, Lab Expt Cardiol, Utrecht, Netherlands.
   [Gohar, Aisha; Hoes, Arno W.; Rutten, Frans H.] Univ Utrecht, Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands.
   [de Kleijn, Dominique P. V.] Univ Utrecht, Univ Med Ctr, Expt Vasc Surg, Utrecht, Netherlands.
   [de Kleijn, Dominique P. V.] Netherlands Heart Inst, Utrecht, Netherlands.
   [de Kleijn, Dominique P. V.] Natl Univ Singapore, Dept Surg, Singapore, Singapore.
   [Hilfiker-Kleiner, Denise] Med Sch Hannover, Dept Cardiol & Angiol, Hannover, Germany.
   [Ferdinandy, Peter] Semmelweis Univ, Dept Pharmacol & Phormacotherapy, Budapest, Hungary.
   [Ferdinandy, Peter] Pharmahungary Grp, Szeged, Hungary.
   [Sluijter, Joost P. G.] Univ Utrecht, Univ Med Ctr Utrecht, Regenerat Med Ctr, Utrecht, Netherlands.
C3 Utrecht University; Utrecht University Medical Center; Utrecht
   University; Utrecht University Medical Center; Utrecht University;
   Utrecht University Medical Center; National University of Singapore;
   Hannover Medical School; Semmelweis University; Pharmahungary Group;
   Utrecht University; Utrecht University Medical Center
RP den Ruijter, HM (corresponding author), Univ Utrecht, Univ Med Ctr Utrecht, Lab Expt Cardiol, Utrecht, Netherlands.
EM H.M.denRuijter-2@umcutrecht.nl
RI Ferdinandy, Péter/H-9181-2019
OI den Ruijter, Hester/0000-0001-9762-014X
FU Netherlands Heart Foundation [2013/T084]; Hungarian National Research,
   Development, and Innovation Office (OTKA) [K 109737, KH 125570, NVKP
   16-1-2016-0017, VEKOP-2.3.2-16-2016-00002]; Horizon2020 ERC-2016-COG
   EVICARE [725229]; Project SMARTCARE-II of the BioMedicalMaterials
   institute; ZonMw-TAS program [116002016]; Dutch Ministry of Economic
   Affairs, Agriculture and Innovation; Netherlands CardioVascular Research
   Initiative (CVON): the Dutch Heart Foundation; Dutch Federations of
   University Medical Centers; Netherlands Organization for Health Research
   and Development; Roy
FX This work is part of the Queen of Hearts Consortium and has been
   supported by a grant from the Netherlands Heart Foundation: 2013/T084.PF
   is the vice chair of the European Cooperation in Science and Technology
   (COST action CA16225, EU-Cardioprotection) and supported by grants from
   the Hungarian National Research, Development, and Innovation Office
   (OTKA K 109737, KH 125570, NVKP 16-1-2016-0017, and
   VEKOP-2.3.2-16-2016-00002).JPGS is supported by Horizon2020 ERC-2016-COG
   EVICARE (725229), the Project SMARTCARE-II of the BioMedicalMaterials
   institute, co-funded by the ZonMw-TAS program (#116002016), the Dutch
   Ministry of Economic Affairs, Agriculture and Innovation and the
   Netherlands CardioVascular Research Initiative (CVON): the Dutch Heart
   Foundation, Dutch Federations of University Medical Centers, the
   Netherlands Organization for Health Research and Development, and the
   Roy.
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NR 82
TC 6
Z9 6
U1 0
U2 5
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1537-1891
EI 1879-3649
J9 VASC PHARMACOL
JI Vasc. Pharmacol.
PD DEC
PY 2018
VL 111
BP 1
EP 6
DI 10.1016/j.vph.2018.05.006
PG 6
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA HE2LX
UT WOS:000453110700001
PM 29807165
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Liang, XZ
   He, HJ
   Zeng, H
   Wei, LY
   Yang, JH
   Wen, YQ
   Fan, SQ
   Fan, JT
AF Liang, Xuzhi
   He, Haijing
   Zeng, Hao
   Wei, Liuyi
   Yang, Jiahuang
   Wen, Yuqi
   Fan, Siqi
   Fan, Jiangtao
TI The relationship between polycystic ovary syndrome and coronary heart
   disease: a bibliometric analysis
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Review
DE polycystic ovary syndrome; coronary heart disease; bibliometric
   analysis; risk factor; VOSviewer; citespace
ID CARDIOVASCULAR RISK-FACTORS; C-REACTIVE PROTEIN; INSULIN-RESISTANCE;
   HOMOCYSTEINE LEVELS; METABOLIC SYNDROME; OXIDATIVE STRESS; SYNDROME
   PCOS; WOMEN; METFORMIN; FAT
AB BackgroundPolycystic ovary syndrome (PCOS) is one of the most common gynecological endocrine diseases for women of puberty and reproductive age. PCOS can affect women's health for the rest of their lives since the incidence of coronary heart disease (CHD) may increase in the perimenopausal and senile periods among PCOS women compared with non-PCOS women. MethodA literature retrieval based on the Science Citation Index Expanded (SCI-E) database. All obtained records results were downloaded in plain text format for subsequent analysis. VOSviewer v1.6.10, Citespace and Microsoft Excel 2010 software were utilized for analyzing the following terms: countries, institutions, authors, journals, references and keywords. ResultsThere were 312 articles retrieved from January 1, 2000 to February 8, 2023, and the frequency of citations was 23,587. The United States, England, and Italy contributed the majority of the records. Harvard University, the University of Athens, and Monash University were the top 3 most productive institutions with publications on the relationship between PCOS and CHD. Journal of clinical endocrinology & metabolism ranked first with the highest publications (24 records), followed by Fertility and sterility (18 records). The keywords were divided into six clusters in the overlay keywords network: (1) the correlation between CHD risk factors and PCOS women; (2) the relationship between cardiovascular disease and female reproductive system hormone secretion; (3) the interaction between CHD and metabolic syndrome; (4) the relationship between c-reactive protein and endothelial function and oxidative stress in PCOS patients; (5) the potential positive effect of metformin on reducing CHD risk factors in PCOS patients; (6) the study of serum cholesterol and body-fat distribution in patients with CHD in PCOS. Oxidative stress, genome-wide association, obesity, primary prevention, and sex difference were main hotspots in this field in recent five years according to the keyword citation burst analysis. ConclusionThe article obtained the hotspots and trends and provided a reference for subsequent research on the association between PCOS and CHD. Moreover, it is hypothesized that oxidative stress and genome-wide association were frontier hotspots in studies that explore the relationship between PCOS and CHD, and prevention research may be valued in the future.
C1 [Liang, Xuzhi; He, Haijing; Zeng, Hao; Wei, Liuyi; Yang, Jiahuang; Wen, Yuqi; Fan, Jiangtao] Guangxi Med Univ, Affiliated Hosp 1, Dept Gynecol, Nanning, Guangxi, Peoples R China.
   [Fan, Siqi] Univ Bonn, Dept Ophthalmol, Bonn, N Rhin Westphal, Germany.
C3 Guangxi Medical University; University of Bonn
RP Fan, JT (corresponding author), Guangxi Med Univ, Affiliated Hosp 1, Dept Gynecol, Nanning, Guangxi, Peoples R China.; Fan, SQ (corresponding author), Univ Bonn, Dept Ophthalmol, Bonn, N Rhin Westphal, Germany.
EM fsq198442@163.com; jt_fan2018@163.com
RI 曾, 昊/HTS-6433-2023; Fan, Siqi/JRY-1339-2023
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NR 57
TC 11
Z9 11
U1 1
U2 20
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD MAY 8
PY 2023
VL 14
AR 1172750
DI 10.3389/fendo.2023.1172750
PG 13
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA G6ND1
UT WOS:000990293400001
PM 37223024
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Reynolds, LP
   Borowicz, PP
   Caton, JS
   Crouse, MS
   Dahlen, CR
   Ward, AK
AF Reynolds, Lawrence P.
   Borowicz, Pawel P.
   Caton, Joel S.
   Crouse, Matthew S.
   Dahlen, Carl R.
   Ward, Alison K.
TI Developmental Programming of Fetal Growth and Development
SO VETERINARY CLINICS OF NORTH AMERICA-FOOD ANIMAL PRACTICE
LA English
DT Article
DE Fetus; Placenta; Growth; Development; Maternal stress; Developmental
   programming; Postnatal health
ID MESSENGER-RNA EXPRESSION; MATERNAL NUTRITION; EARLY-PREGNANCY; THRIFTY
   PHENOTYPE; DNA METHYLATION; OFFSPRING PERFORMANCE; PLACENTAL
   DEVELOPMENT; EPIGENETIC REGULATION; VASCULAR DEVELOPMENT;
   EXPERIMENTAL-MODELS
AB Maternal stressors that affect fetal development result in "developmental programming," which is associated with increased risk of various chronic pathologic conditions in the offspring, including metabolic syndrome; growth abnormalities; and reproductive, immune, behavioral, or cognitive dysfunction that can persist throughout their lifetime and even across subsequent generations. Developmental programming thus can lead to poor health, reduced longevity, and reduced productivity. Current research aims to develop management and therapeutic strategies to optimize fetal growth and development and thereby overcome the negative consequences of developmental programming, leading to improved health, longevity, and productivity of offspring.
C1 [Reynolds, Lawrence P.; Caton, Joel S.; Crouse, Matthew S.; Dahlen, Carl R.; Ward, Alison K.] North Dakota State Univ, Ctr Nutr & Pregnancy, Dept Anim Sci, NDSU Dept 7630, Fargo, ND 58108 USA.
   [Borowicz, Pawel P.] North Dakota State Univ, Ctr Nutr & Pregnancy, Dept Anim Sci, Adv Imaging & Microscopy Core Lab, NDSU Dept 7630, Fargo, ND 58108 USA.
C3 North Dakota State University Fargo; North Dakota State University Fargo
RP Reynolds, LP (corresponding author), North Dakota State Univ, Ctr Nutr & Pregnancy, Dept Anim Sci, NDSU Dept 7630, Fargo, ND 58108 USA.
EM larry.reynolds@ndsu.edu
RI ; Reynolds, Lawrence/I-5267-2015
OI Crouse, Matthew/0000-0003-4579-2737; Reynolds,
   Lawrence/0000-0002-6838-7809; Dahlen, Carl/0000-0002-4556-4315
FU U.S. National Institute of Food and Agriculture, National Institutes of
   Health; National Science Foundation; North Dakota Agricultural
   Experiment Station; North Dakota State Board of Agricultural Research
   and Education
FX Our research over the last thirty years has been supported primarily by
   the U.S. National Institute of Food and Agriculture, National Institutes
   of Health, and National Science Foundation, as well as the North Dakota
   Agricultural Experiment Station and the North Dakota State Board of
   Agricultural Research and Education.
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NR 113
TC 104
Z9 118
U1 5
U2 20
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0749-0720
EI 1558-4240
J9 VET CLIN N AM-FOOD A
JI Vet. Clin. N. Am.-Food Anim. Pract.
PD JUL
PY 2019
VL 35
IS 2
BP 229
EP +
DI 10.1016/j.cvfa.2019.02.006
PG 20
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA ID5TX
UT WOS:000471740000002
PM 31103178
OA Bronze
DA 2025-06-11
ER

PT J
AU Tao, SY
   Yu, LT
   Li, J
   Wu, J
   Yang, DS
   Huang, XC
   Xue, TT
AF Tao, Shiyi
   Yu, Lintong
   Li, Jun
   Wu, Ji
   Yang, Deshuang
   Huang, Xuanchun
   Xue, Tiantian
TI Elevated remnant cholesterol and the risk of prevalent major depressive
   disorder: a nationwide population-based study
SO FRONTIERS IN PSYCHIATRY
LA English
DT Article
DE remnant cholesterol; major depressive disorder; dyslipidemia; PHQ-9;
   NHANES
ID TREATMENT-RESISTANT DEPRESSION; METABOLIC SYNDROME; LDL CHOLESTEROL;
   ASSOCIATION; SEVERITY; SYMPTOMS; DISEASE; METAANALYSIS; ANXIETY; PHQ-9
AB Background: Remnant cholesterol (RC) has received increasing attention due to its association with a variety of diseases. However, comprehensive population-based studies elucidating the relationship between RC and major depressive disorder (MDD) are limited. The current study aimed to determine the association between RC and MDD in US adults.
   Methods: Cross-sectional data of US adults with complete RC and depression information were obtained from the National Health and Nutrition Examination Survey (NHANES) 2005-2018. MDD was evaluated using the Patient Health Questionnaire (PHQ-9). Multivariate logistic regression, sensitivity analysis, and spline smoothing plot method were conducted to explore the relationship between RC and depression. The cut-off point was calculated using recursive partitioning analysis when segmenting effects emerged. The area under the receiver operating characteristic (ROC) curve (AUC), calibration curve, Hosmer-Lemeshow test, the decision curve analysis (DCA), and clinical impact curve (CIC) were employed to evaluate the performance of RC in identifying MDD. Subgroup analyses and interaction tests were performed to explore whether the association was stable in different populations.
   Results: A total of 9,173 participants were enrolled and participants in the higher RC quartile tended to have a higher PHQ-9 score and prevalence of MDD. In the fully adjusted model, a positive association between RC and PHQ-9 score and MDD was both observed (beta=0.54, 95% CI 0.26 similar to 0.82; OR=1.43, 95% CI 1.15 similar to 1.78). Participants in the highest RC quartile had a 0.42-unit higher PHQ-9 score (beta=0.42, 95% CI 0.15 similar to 0.69) and a significantly 32% higher risk of MDD than those in the lowest RC quartile (OR=1.32, 95% CI 1.05 similar to 1.66). Spline smoothing plot analysis further confirmed the positive and non-linear association between RC and PHQ-9 and MDD. ROC analysis (AUC=0.762), the Hosmer-Lemeshow test (chi(2) = 6.258, P=0.618), and calibration curve all indicated a high performance and goodness-of-fit of the multivariate model. DCA and CIC analysis similarly demonstrated a positive overall net benefit and clinical impact for the model. Subgroup analyses and interaction tests suggested that the relationship between RC and depression remained stable across subgroups and was unaffected by other factors other than diabetes, hypertension, or hyperlipidemia.
   Conclusion: An elevated RC is associated with a higher risk of prevalent MDD among US adults, especially in those with diabetes, hypertension, or hyperlipidemia. The present results suggested that the management of RC levels and comorbidities may contribute to alleviating the occurrence of MDD.
C1 [Tao, Shiyi; Li, Jun; Wu, Ji; Huang, Xuanchun; Xue, Tiantian] China Acad Chinese Med Sci, Guanganmen Hosp, Dept Cardiol, Beijing, Peoples R China.
   [Tao, Shiyi; Yu, Lintong] Beijing Univ Chinese Med, Grad Sch, Beijing, Peoples R China.
   [Yang, Deshuang] China Japan Friendship Hosp, Dept Integrat Cardiol, Beijing, Peoples R China.
C3 China Academy of Chinese Medical Sciences; Guang'anmen Hospital, CACMS;
   Beijing University of Chinese Medicine; China-Japan Friendship Hospital
RP Li, J (corresponding author), China Acad Chinese Med Sci, Guanganmen Hosp, Dept Cardiol, Beijing, Peoples R China.
EM gamyylj@163.com
FU High Level Chinese Medical Hospital Promotion Project [HLCMHPP2023065];
   National Key Research and Development Program of China [2022YFC3500102]
FX The author(s) declare that financial support was received for the
   research, authorship, and/or publication of this article. This work was
   supported by the High Level Chinese Medical Hospital Promotion Project
   (No. HLCMHPP2023065) and the National Key Research and Development
   Program of China (No. 2022YFC3500102).
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NR 54
TC 0
Z9 0
U1 1
U2 1
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-0640
J9 FRONT PSYCHIATRY
JI Front. Psychiatry
PD NOV 14
PY 2024
VL 15
AR 1495467
DI 10.3389/fpsyt.2024.1495467
PG 12
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA O0F0V
UT WOS:001367976000001
PM 39611132
OA gold
DA 2025-06-11
ER

PT J
AU Sautin, YY
   Johnson, RJ
AF Sautin, Yuri Y.
   Johnson, Richard J.
TI Uric acid: The oxidant-antioxidant paradox
SO NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
LA English
DT Article; Proceedings Paper
CT 12th International Symposium on Purine and Pyrimidine Metabolism
CY JUN 24-28, 2007
CL Chicago, IL
DE uric acid; redox homeostasis; metabolic syndrome; cardiovascular disease
ID TYROSINE NITRATION; NADPH OXIDASES; BLOOD-PRESSURE; IMMUNE-SYSTEM; URATE
   OXIDASE; FREE-RADICALS; PEROXYNITRITE; HYPERTENSION; INFLAMMATION;
   OXIDATION
AB Uric acid, despite being a major antioxidant in the human plasma, both correlates and predicts development of obesity, hypertension, and cardiovascular disease, conditions associated with oxidative stress. While one explanation for this paradox could be that a rise in uric acid represents an attempted protective response by the host, we review the evidence that uric acid may function either as an antioxidant (primarily in plasma) or pro-oxidant (primarily within the cell). We suggest that it is the pro-oxidative effects of uric acid that occur in cardiovascular disease and may have a contributory role in the pathogenesis of these conditions.
C1 [Sautin, Yuri Y.; Johnson, Richard J.] Univ Florida, Dept Med, Div Nephrol Hypertens & Transplantat, Gainesville, FL 32610 USA.
C3 State University System of Florida; University of Florida
RP Johnson, RJ (corresponding author), Univ Florida, Dept Med, Div Nephrol Hypertens & Transplantat, POB 100224, Gainesville, FL 32610 USA.
EM johnsrj@medicine.ufl.edu
OI Sautin, Yuri/0000-0003-3618-5134
FU NHLBI NIH HHS [HL-68607, R01 HL068607] Funding Source: Medline
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NR 59
TC 665
Z9 709
U1 4
U2 55
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1525-7770
EI 1532-2335
J9 NUCLEOS NUCLEOT NUCL
JI Nucleosides Nucleotides Nucleic Acids
PY 2008
VL 27
IS 6-7
BP 608
EP 619
DI 10.1080/15257770802138558
PG 12
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Biochemistry & Molecular Biology
GA 321XA
UT WOS:000257338600014
PM 18600514
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Petta, S
   Gastaldelli, A
   Rebelos, E
   Bugianesi, E
   Messa, P
   Miele, L
   Svegliati-Baroni, G
   Valenti, L
   Bonino, F
AF Petta, Salvatore
   Gastaldelli, Amalia
   Rebelos, Eleni
   Bugianesi, Elisabetta
   Messa, Piergiorgio
   Miele, Luca
   Svegliati-Baroni, Gianluca
   Valenti, Luca
   Bonino, Ferruccio
TI Pathophysiology of Non Alcoholic Fatty Liver Disease
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE fatty liver; insulin resistance; free fatty acids; cholesterol;
   adiponectin; leptin; insulin; glucagon; glucagon-like peptide 1;
   ghrelin; irisin; selenoprotein P
ID GLUCAGON-LIKE PEPTIDE-1; ENDOPLASMIC-RETICULUM STRESS; CARDIOVASCULAR
   RISK-FACTORS; HEPATIC INSULIN-RESISTANCE; HIGH-INTENSITY EXERCISE;
   FETUIN-A CONCENTRATIONS; CORONARY-HEART-DISEASE; CHRONIC KIDNEY-DISEASE;
   SELENOPROTEIN-P; ACYL-GHRELIN
AB The physiopathology of fatty liver and metabolic syndrome are influenced by diet, life style and inflammation, which have a major impact on the severity of the clinicopathologic outcome of non-alcoholic fatty liver disease. A short comprehensive review is provided on current knowledge of the pathophysiological interplay among major circulating effectors/mediators of fatty liver, such as circulating lipids, mediators released by adipose, muscle and liver tissues and pancreatic and gut hormones in relation to diet, exercise and inflammation.
C1 [Petta, Salvatore] Univ Palermo, DiBiMIS Policlin Paolo Giaccone Hosp, Gastroenterol, I-90127 Palermo, Italy.
   [Gastaldelli, Amalia] CNR, Cardiometabol Risk Unit, Inst Clin Physiol, I-56124 Pisa, Italy.
   [Rebelos, Eleni; Bonino, Ferruccio] Univ Pisa, Dept Clin & Expt Med, I-56122 Pisa, Italy.
   [Bugianesi, Elisabetta] Univ Turin, Gastroenterol & Hepatol, Dept Med Sci, Citta Salute & Sci Torino Hosp, I-10122 Turin, Italy.
   [Messa, Piergiorgio] Fdn IRCCS Ca Granda, Dept Nephrol Urol & Renal Transplant, I-20122 Milan, Italy.
   [Miele, Luca] Univ Cattolica Sacro Cuore, Inst Internal Med, Gastroenterol & Liver Dis Unit, Fdn Policlin Gemelli, I-00168 Rome, Italy.
   [Svegliati-Baroni, Gianluca] Polytech Univ Marche, Dept Gastroenterol & Obes 2 1, I-60121 Ancona, Italy.
   [Valenti, Luca] Univ Milan, Fdn IRCCS Ca Granda, Metab Liver Dis, Via F Sforza 35, I-20122 Milan, Italy.
   [Bonino, Ferruccio] Inst Hlth, I-53042 Chianciano Terme, Italy.
C3 University of Palermo; Policlinico Paolo Giaccone; Consiglio Nazionale
   delle Ricerche (CNR); Istituto di Fisiologia Clinica (IFC-CNR);
   University of Pisa; A.O.U. Citta della Salute e della Scienza di Torino;
   University of Turin; IRCCS Ca Granda Ospedale Maggiore Policlinico;
   Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli;
   Marche Polytechnic University; IRCCS Ca Granda Ospedale Maggiore
   Policlinico; University of Milan
RP Bonino, F (corresponding author), Univ Pisa, Dept Clin & Expt Med, I-56122 Pisa, Italy.; Bonino, F (corresponding author), Inst Hlth, I-53042 Chianciano Terme, Italy.
EM petsa@inwind.it; amalia@ifc.cnr.it; elenirebelos@gmail.com;
   ebugianesi@yahoo.it; pmessa@policlinico.mi.it;
   luca.miele@policlinicogemelli.it; gsvegliati@gmail.com;
   luca.valenti@unimi.it; ferruccio.bonino@unipi.it
RI Bugianesi, Elisabetta/K-8008-2016; Rebelos, Eleni/ABI-5173-2020; Miele,
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   Amalia/H-3319-2014; Valenti, Luca/B-3695-2009
OI messa, piergiorgio/0000-0002-1512-559X; Miele, Luca/0000-0003-3464-0068;
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NR 202
TC 116
Z9 137
U1 0
U2 20
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD DEC
PY 2016
VL 17
IS 12
AR 2082
DI 10.3390/ijms17122082
PG 26
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA EI1XR
UT WOS:000392280500126
PM 27973438
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Truong, E
   Noureddin, M
AF Truong, Emily
   Noureddin, Mazen
TI The Interplay Between Nonalcoholic Fatty Liver Disease and Kidney
   Disease
SO CLINICS IN LIVER DISEASE
LA English
DT Article
DE Chronic kidney disease; Hepatocellular carcinoma; Nonalcoholic fatty
   liver disease; Type 2 diabetes mellitus
ID TRANSIENT ELASTOGRAPHY; PROSPECTIVE DERIVATION; INTESTINAL MICROBIOTA;
   OXIDATIVE STRESS; PNPLA3 GENE; FIBROSIS; STEATOSIS; NAFLD; RISK;
   STEATOHEPATITIS
AB Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease worldwide, involving approximately 25% of the general population and increasing in prevalence in patient populations afflicted with metabolic syndrome and type 2 diabetes. This article discusses the complex interplay between NAFLD and chronic kidney disease (CKD), as well as the underlying pathogenesis and mechanisms through which NAFLD and CKD are linked. Exploration of these sophisticated relationships and causative factors is essential to accurately assessing kidney function in patients with NAFLD, recommending pharmacologic treatment of disease, and identifying favorable avenues for future investigation.
C1 [Truong, Emily] Dept Med, 8700 Beverly Blvd,5512, Los Angeles, CA 90048 USA.
   [Truong, Emily] Cedars Sinai Med Ctr, 8900 Beverly Blvd, Los Angeles, CA 90048 USA.
   [Noureddin, Mazen] Cedars Sinai Med Ctr, Comprehens Transplant Ctr, Dept Med, Karsh Div Gastroenterol & Hepatol, Los Angeles, CA 90048 USA.
   [Noureddin, Mazen] Cedars Sinai Med Ctr, Comprehens Transplant Ctr, Dept Med, Cedars Sinai Fatty Liver Program,Div Digest & Liv, 8900 Beverly Blvd, Los Angeles, CA 90048 USA.
C3 Cedars Sinai Medical Center; Cedars Sinai Medical Center; Cedars Sinai
   Medical Center
RP Noureddin, M (corresponding author), Cedars Sinai Med Ctr, Comprehens Transplant Ctr, Dept Med, Cedars Sinai Fatty Liver Program,Div Digest & Liv, 8900 Beverly Blvd, Los Angeles, CA 90048 USA.
EM Mazen.Noureddin@cshs.org
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NR 70
TC 9
Z9 9
U1 1
U2 18
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 1089-3261
EI 1557-8224
J9 CLIN LIVER DIS
JI Clin. Liver Dis.
PD MAY
PY 2022
VL 26
IS 2
BP 213
EP 227
DI 10.1016/j.cld.2022.01.008
EA APR 2022
PG 15
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 3L6PX
UT WOS:000834884100006
PM 35487606
DA 2025-06-11
ER

PT J
AU Ilan, Y
AF Ilan, Yaron
TI Immune Therapy for Nonalcoholic Steatohepatitis Are We There Yet?
SO JOURNAL OF CLINICAL GASTROENTEROLOGY
LA English
DT Review
DE NASH; immune metabolism; metabolism; treatment
ID FATTY LIVER-DISEASE; ALLEVIATES INSULIN-RESISTANCE;
   ENDOPLASMIC-RETICULUM STRESS; REGULATORY T-CELLS; HEPATIC STEATOSIS;
   CD3-SPECIFIC ANTIBODY; CLINICAL-TRIALS; PENTOXIFYLLINE; INFLAMMATION;
   DIET
AB Metabolic syndrome, obesity, and nonalcoholic steatohepatitis are associated with a state of chronic inflammation. The immune system and the inflammatory cascade can be involved in the development of any of the above common conditions. This association raises the question of whether immune therapy can be used for the treatment of nonalcoholic steatohepatitis. Although immune therapy is not yet feasible for clinical use, here, we review some of the recent data on the potential role of the various arms of the immune system in the development of nonalcoholic steatohepatitis and several potential therapeutic targets.
C1 [Ilan, Yaron] Hadassah Hebrew Univ Med Ctr, Dept Med, Gastroenterol Unit, IL-91120 Jerusalem, Israel.
   [Ilan, Yaron] Hadassah Hebrew Univ Med Ctr, Dept Med, Liver Unit, IL-91120 Jerusalem, Israel.
C3 Hebrew University of Jerusalem; Hadassah University Hospital; Hebrew
   University of Jerusalem; Hadassah University Hospital
RP Ilan, Y (corresponding author), Hadassah Hebrew Univ Med Ctr, Dept Med, Gastroenterol Unit, POB 12000, IL-91120 Jerusalem, Israel.
EM ilan@hadassah.org.il
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NR 105
TC 13
Z9 15
U1 0
U2 9
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0192-0790
EI 1539-2031
J9 J CLIN GASTROENTEROL
JI J. Clin. Gastroenterol.
PD APR
PY 2013
VL 47
IS 4
BP 298
EP 307
DI 10.1097/MCG.0b013e31827873dc
PG 10
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 105ZS
UT WOS:000316111800005
PM 23442833
DA 2025-06-11
ER

PT J
AU de Beaurepaire, R
AF de Beaurepaire, Renaud
TI Binge Eating Disorders in Antipsychotic-Treated Patients With
   Schizophrenia Prevalence, Antipsychotic Specificities, and Changes Over
   Time
SO JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
LA English
DT Article
DE binge eating spectrum; clozapine; olanzapine; aripiprazole; night
   eating; metabolic syndrome
ID OBESE INDIVIDUALS; RISK; CLOZAPINE; EXPRESSION; DEPRESSION; OLANZAPINE;
   SPECTRUM
AB Background
   Excessive energy intake likely favors metabolic dysfunction in patients with schizophrenia and may be, in part, the consequence of antipsychotic treatments. However, previous studies on the prevalence of bulimia and binge eating symptoms in antipsychotic-treated patients are contradictory and not sufficiently informative. Methods
   The prevalence of bulimia nervosa, binge eating disorder, and subsyndromal binge eating disorder was studied using Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, criteria in 156 patients with schizophrenia or schizoaffective disorder treated with antipsychotic monotherapy. The effects of different antipsychotics were compared. Results
   The prevalence of full syndromal binge eating disorder was 4.4% and that of subsyndromal binge eating disorder was 18.7% in patients (23.1% for binge eating spectrum disorder), and there were no cases of bulimia nervosa. Compared with the whole sample, binge eating spectrum disorders were significantly more prevalent in clozapine- and olanzapine-treated patients. Comparisons of patients having undergone treatment for 2 years or less with patients treated for more than 2 years showed that binge eating spectrum disorders decrease significantly over time, the difference being significant in clozapine- and olanzapine-treated patients. Night eating, simply assessed by a single question, showed a prevalence of 30% and was more prevalent in women treated with clozapine and olanzapine, with no significant change over time. Conclusions
   Binge eating disorders should be considered as important factors involved in the development of weight gain and metabolic syndrome in antipsychotic-treated patients with schizophrenia. The difficulty to reliably assess binge eating spectrum disorders in patients with psychosis is highlighted.
C1 [de Beaurepaire, Renaud] Grp Hosp Paul Guiraud, 54 Ave Republ, F-94806 Villejuif, France.
RP de Beaurepaire, R (corresponding author), Grp Hosp Paul Guiraud, 54 Ave Republ, F-94806 Villejuif, France.
EM debeaurepaire@wanadoo.fr
FU Groupe Hospitalier Paul-Guiraud
FX This work was supported by the Groupe Hospitalier Paul-Guiraud, which
   made available all the resources necessary for this work.
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NR 46
TC 19
Z9 19
U1 0
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0271-0749
EI 1533-712X
J9 J CLIN PSYCHOPHARM
JI J. Clin. Psychopharmacol.
PD MAR-APR
PY 2021
VL 41
IS 2
BP 114
EP 120
DI 10.1097/JCP.0000000000001357
PG 7
WC Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Pharmacology & Pharmacy; Psychiatry
GA SK9EK
UT WOS:000656521700006
PM 33587392
DA 2025-06-11
ER

PT J
AU Kadry, D
   Hegazy, RA
   Rashed, L
AF Kadry, D.
   Hegazy, R. A.
   Rashed, L.
TI Osteopontin and adiponectin: how far are they related in the complexity
   of psoriasis?
SO ARCHIVES OF DERMATOLOGICAL RESEARCH
LA English
DT Article
DE Adiponectin; Metabolic syndrome; Osteopontin; Psoriasis
ID ADIPOSE-TISSUE; INSULIN-RESISTANCE; INFLAMMATION; PROFILE; LEPTIN;
   GROWTH; ETA-1
AB Increasing attention has been drawn towards the involvement of both osteopontin (OPN) and adiponectin in psoriasis. The relationship between them has been studied before in the context of essential hypertension. To our knowledge, whether a relation between them exists in cases of psoriasis and the metabolic status in such patients have not been investigated. We aimed to verify their possible roles and relations in psoriasis and its metabolic associations. 35 patients with psoriasis vulgaris and 35 controls were included. Patients were clinically assessed by PASI and investigated for the presence of metabolic syndrome (MetS) and/or its components. Plasma levels of OPN and adiponectin were measured using ELISA. On comparing psoriatics to controls, patients showed significantly elevated levels of OPN (90.474 +/- A 21.22 vs 34.709 +/- A 13.95 ng/mL) and significantly depressed levels of adiponectin (4,586 +/- A 1.187 vs 5,905 +/- A 1.374 ng/mL), (p < 0.001). Strong negative correlation between plasma OPN and adiponectin was detected in patients (r = -0.912, p < 0.001), but not in controls. OPN elevation was related to diabetes mellitus, insulin resistance, and MetS. Adiponectin depression was related to body mass index, and MetS. This study demonstrates for the first time a significant correlation between OPN and adiponectin in psoriasis, hypothesized to be mostly attributed to the inflammatory milieu of psoriasis and MetS as well as the enhanced renin-angiotensin-aldosterone system previously documented in psoriasis. Adjuvant therapies aiming at modulating levels of OPN and adiponectin are speculated to add benefit in psoriasis treatment and protecting against its metabolic risks.
C1 [Kadry, D.; Hegazy, R. A.] Cairo Univ, Fac Med, Dept Dermatol, Cairo, Egypt.
   [Rashed, L.] Cairo Univ, Fac Med, Dept Biochem, Cairo, Egypt.
C3 Egyptian Knowledge Bank (EKB); Cairo University; Egyptian Knowledge Bank
   (EKB); Cairo University
RP Kadry, D (corresponding author), 13-2 Zahraa St,Sect 5, Cairo, Egypt.
EM dina.mkadry@gmail.com
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NR 33
TC 13
Z9 14
U1 0
U2 6
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0340-3696
EI 1432-069X
J9 ARCH DERMATOL RES
JI Arch. Dermatol. Res.
PD DEC
PY 2013
VL 305
IS 10
BP 939
EP 944
DI 10.1007/s00403-013-1392-z
PG 6
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 256NT
UT WOS:000327320600010
PM 23884541
DA 2025-06-11
ER

PT J
AU Pearce, D
AF Pearce, D
TI The role of SGK1 in hormone-regulated sodium transport
SO TRENDS IN ENDOCRINOLOGY AND METABOLISM
LA English
DT Review
ID THREONINE PROTEIN-KINASE; EPITHELIAL NA+ CHANNEL; CULTURED KIDNEY-CELLS;
   MINERALOCORTICOID RECEPTORS; COLLECTING DUCT; PHOSPHOINOSITIDE 3-KINASE;
   GLUCOCORTICOID RECEPTORS; ALDOSTERONE ACTION; PROMOTER ACTIVITY;
   INDUCIBLE KINASE
AB Ion transport in epithelia is regulated by a variety of hormonal and nonhormonal factors, including mineralocorticoids, insulin, shear stress and osmotic pressure. In mammals, the mineralocorticoid aldosterone is the principal regulator of sodium homeostasis and hence is central to the control of extracellular fluid volume and blood pressure. Aldosterone acts through a member of the nuclear receptor superfamily, the mineralocorticoid receptor (MR),to control the transcriptional activity of specific target genes. Recently, a serine/threonine kinase, SGK1 (serum and glucocorticoid-regulated kinase isoform 1) was identified as a candidate mediator of aldosterone action in the colon and distal nephron. The aldosterone-activated MR increases SGK1 gene transcription and SGK1, in turn, strongly stimulates the activity of the epithelial sodium channel (ENaC). Interestingly, other factors appear to regulate SGK1 gene expression and kinase activity, Insulin, for example, stimulates SGK1 activity (but not gene transcription) through its effects on phosphatidylinositol-3-kinase and osmotic shock appears to stimulate both SGK1 activity and gene transcription. Hence, SGK1 might integrate the effects of multiple hormonal and nonhormonal regulators of Na+ transport in tight epithelia and thereby play a key role in volume homeostasis. It is interesting to speculate that SGK1 might be implicated in medical conditions, such as the insulin resistance syndrome, hypertension and congestive heart failure.
C1 Univ Calif San Francisco, Div Nephrol, Dept Med, San Francisco, CA 94143 USA.
   Univ Calif San Francisco, Dept Cellular & Mol Pharmacol, San Francisco, CA 94143 USA.
C3 University of California System; University of California San Francisco;
   University of California System; University of California San Francisco
RP Pearce, D (corresponding author), Univ Calif San Francisco, Div Nephrol, Dept Med, Box 0532, San Francisco, CA 94143 USA.
FU NIDDK NIH HHS [DK56695, DK51151] Funding Source: Medline; National
   Institute of Diabetes and Digestive and Kidney Diseases [R01DK056695]
   Funding Source: NIH RePORTER
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NR 80
TC 73
Z9 85
U1 0
U2 4
PU ELSEVIER SCIENCE LONDON
PI LONDON
PA 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND
SN 1043-2760
J9 TRENDS ENDOCRIN MET
JI Trends Endocrinol. Metab.
PD OCT
PY 2001
VL 12
IS 8
BP 341
EP 347
DI 10.1016/S1043-2760(01)00439-8
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 475FW
UT WOS:000171152500003
PM 11551807
DA 2025-06-11
ER

PT J
AU Jichitu, A
   Bungau, S
   Stanescu, AMA
   Vesa, CM
   Toma, MM
   Bustea, C
   Iurciuc, S
   Rus, M
   Bacalbasa, N
   Diaconu, CC
AF Jichitu, Alexandra
   Bungau, Simona
   Stanescu, Ana Maria Alexandra
   Vesa, Cosmin Mihai
   Toma, Mirela Marioara
   Bustea, Cristiana
   Iurciuc, Stela
   Rus, Marius
   Bacalbasa, Nicolae
   Diaconu, Camelia Cristina
TI Non-Alcoholic Fatty Liver Disease and Cardiovascular Comorbidities:
   Pathophysiological Links, Diagnosis, and Therapeutic Management
SO DIAGNOSTICS
LA English
DT Review
DE non-alcoholic fatty liver disease; cardiovascular comorbidities;
   pathophysiology; treatment
ID GAMMA-GLUTAMYL-TRANSFERASE; INSULIN-SENSITIZING AGENTS;
   CORONARY-ARTERY-DISEASE; NECROSIS-FACTOR-ALPHA; ATRIAL-FIBRILLATION;
   METABOLIC SYNDROME; DIABETES-MELLITUS; OXIDATIVE STRESS; HEART-FAILURE;
   ASYMMETRIC DIMETHYLARGININE
AB Non-alcoholic fatty liver disease (NAFLD) has a growing prevalence in recent years. Its association with cardiovascular disease has been intensively studied, and certain correlations have been identified. The connection between these two entities has lately aroused interest regarding therapeutic management. In order to find the best therapeutic options, a detailed understanding of the pathophysiology that links (NAFLD) to cardiovascular comorbidities is needed. This review focuses on the pathogenic mechanisms that are behind these two diseases and on the therapeutic management available at this time.
C1 [Jichitu, Alexandra; Diaconu, Camelia Cristina] Clin Emergency Hosp Bucharest, Bucharest 105402, Romania.
   [Bungau, Simona; Toma, Mirela Marioara] Univ Oradea, Fac Med & Pharm, Dept Pharm, Oradea 410028, Romania.
   [Stanescu, Ana Maria Alexandra; Diaconu, Camelia Cristina] Carol Davila Univ Med & Pharm, Fac Med, Dept 5, Bucharest 050474, Romania.
   [Vesa, Cosmin Mihai; Bustea, Cristiana] Univ Oradea, Fac Med & Pharm, Dept Preclin Disciplines, Oradea 410073, Romania.
   [Iurciuc, Stela] Victor Babes Univ Med & Pharm, Fac Med, Dept Cardiol, Timisoara 300041, Romania.
   [Rus, Marius] Univ Oradea, Fac Med & Pharm, Dept Med Disciplines, Oradea 410073, Romania.
   [Bacalbasa, Nicolae] Carol Davila Univ Med & Pharm, Fac Med, Dept 13, Bucharest 050474, Romania.
   [Bacalbasa, Nicolae] Ion Cantacuzino Clin Hosp, Dept Surg, Bucharest 030167, Romania.
C3 University of Oradea; Carol Davila University of Medicine & Pharmacy;
   University of Oradea; Victor Babes University of Medicine & Pharmacy,
   Timisoara; University of Oradea; Carol Davila University of Medicine &
   Pharmacy; Cantacuzino Institute Bucharest
RP Bungau, S (corresponding author), Univ Oradea, Fac Med & Pharm, Dept Pharm, Oradea 410028, Romania.; Iurciuc, S (corresponding author), Victor Babes Univ Med & Pharm, Fac Med, Dept Cardiol, Timisoara 300041, Romania.
EM jichitualexandra@yahoo.com; simonabungau@gmail.com;
   alexandrazotta@yahoo.com; v_cosmin_15@yahoo.com; mire.toma@yahoo.com;
   cristianabustea@yahoo.com; iurciuc.stela@umft.ro; rusmariusr@yahoo.com;
   nicolae_bacalbasa@yahoo.ro; drcameliadiaconu@gmail.com
RI Iurciuc, Stela/LVS-1519-2024; Bustea, Cristiana/AAD-3310-2022; Toma,
   Mirela/AAD-3040-2022; bacalbasa, nicolae/HJZ-4552-2023; Mihai,
   Vesa/AAE-5495-2019; Rus, Marius/AAD-2953-2022; Stanescu,
   Ana/L-8439-2019; Bungau, Simona Gabriela/C-1831-2015; Diaconu,
   Camelia/A-2144-2019
OI Iurciuc, Stela/0000-0003-3536-6099; /0000-0003-3236-1292; Marius,
   Rus/0000-0002-4526-9076; Cosmin Mihai, Vesa/0000-0001-5071-9601;
   Stanescu, Ana Maria Alexandra/0000-0002-4807-9470
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NR 230
TC 22
Z9 23
U1 0
U2 30
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2075-4418
J9 DIAGNOSTICS
JI Diagnostics
PD APR
PY 2021
VL 11
IS 4
AR 689
DI 10.3390/diagnostics11040689
PG 30
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA RR2WX
UT WOS:000642966300001
PM 33921359
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Bhansali, S
   Bhansali, A
   Dhawan, V
AF Bhansali, Shipra
   Bhansali, Anil
   Dhawan, Veena
TI Favourable metabolic profile sustains mitophagy and prevents metabolic
   abnormalities in metabolically healthy obese individuals
SO DIABETOLOGY & METABOLIC SYNDROME
LA English
DT Article
DE Metabolically healthy non-obese (MHNO); Metabolically healthy obese
   (MHO); Metabolically abnormal diabetic obese (MADO); Mitochondrial
   oxidative stress and mitophagy
ID MITOCHONDRIAL DYSFUNCTION; OXIDATIVE STRESS; ROS
AB Background: Obesity-mediated oxidative stress results in mitochondrial dysfunction, which has been implicated in the pathogenesis of metabolic syndrome and T2DM. Recently, mitophagy, a cell-reparative process has emerged as a key facet in maintaining the mitochondrial health, which may contribute to contain the metabolic abnormalities in obese individuals. However, the status of mitophagy in metabolically healthy obese (MHO) and metabolically abnormal diabetic obese (MADO) subjects remains to be elucidated. Hence, the present study aims to unravel the alterations in mitochondrial oxidative stress (MOS) and mitophagy in these subjects.
   Methods: 60 subjects including MHNO (metabolically healthy non-obese), MHO and MADO were enrolled as per the Asian criteria for obesity (n = 20 each). Biochemical parameters, MOS indices, transcriptional and translational expression of mitophagy markers (PINK1, PARKIN, MFN2, NIX, LC3-II, and LAMP-2), and transmission electron microscopic (TEM) studies were performed in peripheral blood mononuclear cells.
   Results: The MHO subjects displayed a favorable metabolic profile, despite accompanied by an increased adiposity as compared to the MHNO group; while MADO group exhibited several metabolic abnormalities, inspite of similar body composition as MHO subjects. A progressive rise in the MOS was observed in MHO and MADO subjects as compared to the MHNO group, and it showed a positive and significant correlation with the body composition in these groups. Further, mitophagy remained unaltered in the MHO group, while it was significantly downregulated in the MADO group. In addition, TEM studies revealed a significant increase in the percentage of damaged mitochondria in MADO patients as compared to other groups, while MHO and MHNO groups did not show any significant alterations for the same.
   Conclusion: A favorable metabolic profile and moderate levels of MOS in the MHO group may play a crucial role in the sustenance of mitophagy, which may further limit the aggravation of MOS, inflammation, and emergence of metabolic aberrations in contrast to MADO subjects, who exhibited multiple metabolic abnormalities and attenuated mitophagy. Therefore, these MHO subjects are likely to be at a lower risk of developing metabolic syndrome and T2DM.
C1 [Bhansali, Shipra; Dhawan, Veena] Postgrad Inst Med Educ & Res PGIMER, Dept Expt Med & Biotechnol, Res Block B, Chandigarh 160012, India.
   [Bhansali, Anil] Postgrad Inst Med Educ & Res PGIMER, Dept Endocrinol, Chandigarh, India.
C3 Post Graduate Institute of Medical Education & Research (PGIMER),
   Chandigarh; Post Graduate Institute of Medical Education & Research
   (PGIMER), Chandigarh
RP Dhawan, V (corresponding author), Postgrad Inst Med Educ & Res PGIMER, Dept Expt Med & Biotechnol, Res Block B, Chandigarh 160012, India.
EM veena447@gmail.com
OI Dhawan, Veena/0000-0001-9464-1033
FU Department of Biotechnology (DBT), New Delhi, India
FX The financial grant for the study was received from the Department of
   Biotechnology (DBT), New Delhi, India.
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NR 29
TC 20
Z9 21
U1 0
U2 1
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1758-5996
J9 DIABETOL METAB SYNDR
JI Diabetol. Metab. Syndr.
PD DEC 12
PY 2017
VL 9
AR 99
DI 10.1186/s13098-017-0298-x
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA FQ3UR
UT WOS:000418283100001
PM 29255491
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Takeuchi, T
   Nakao, M
   Nomura, K
   Yano, E
AF Takeuchi, Takeaki
   Nakao, Mutsuhiro
   Nomura, Kyoko
   Yano, Eiji
TI Association of metabolic syndrome with smoking and alcohol intake in
   Japanese men
SO NICOTINE & TOBACCO RESEARCH
LA English
DT Article
ID CIGARETTE-SMOKING; MAJOR DEPRESSION; CARDIOVASCULAR-DISEASE;
   BLOOD-PRESSURE; HEART-RATE; RISK; DRINKING; POPULATION; PLASMA; HEALTH
AB There have been conflicting findings on whether metabolic syndrome (MetS) is associated with smoking and alcohol intake. This study investigated the association of MetS with smoking and alcohol intake.
   MetS was defined according to the International Diabetes Federation criteria, and smoking and alcohol intake were evaluated for 1,215 Japanese male workers using a questionnaire. The association of MetS with smoking and alcohol intake was assessed using logistic regression after adjusting for potential confounders. Proportional analyses for the prevalence of MetS among smoking and alcohol intake were performed as well.
   Among the subjects, 148 (12%) were diagnosed with MetS, 485 (40%) were smokers, and 954 (79%) were regular alcohol users. The prevalence of MetS was the highest (19%) in smokers who did not drink, followed by smokers who also drank (13%), nonsmokers who drank (12%), and those who neither smoked nor drank (7%). Smoking itself was positively related to MetS (odds ratio [OR] = 1.4; 95% CI = 1.1-2.1) and MetS components, including larger waist circumference (OR = 1.5; 95% CI = 1.2-1.9), elevated triglyceride (OR = 1.9; 95% CI = 1.4-2.4), and reduced high-density lipoprotein cholesterol (OR = 1.7; 95% CI = 1.1-2.7). Alcohol intake was not significantly related to MetS; it was positively correlated only to higher fasting plasma glucose (OR = 1.7; 95% CI = 1.1-2.6).
   These results suggest that cigarette smoking is an independent risk factor for MetS, but the risk does not seem to be exaggerated by alcohol intake.
C1 [Takeuchi, Takeaki] Teikyo Univ, Sch Med, Dept Hyg & Publ Hlth, Itabashi Ku, Tokyo 1738605, Japan.
   [Takeuchi, Takeaki; Nakao, Mutsuhiro; Nomura, Kyoko; Yano, Eiji] Teikyo Univ Hosp, Div Psychosomat Med, Tokyo, Japan.
C3 Teikyo University; Teikyo University
RP Takeuchi, T (corresponding author), Teikyo Univ, Sch Med, Dept Hyg & Publ Hlth, Itabashi Ku, 2-11-1 Kaga, Tokyo 1738605, Japan.
EM takeakij@post.harvard.edu
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NR 35
TC 14
Z9 21
U1 0
U2 1
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1462-2203
EI 1469-994X
J9 NICOTINE TOB RES
JI Nicotine Tob. Res.
PD SEP
PY 2009
VL 11
IS 9
BP 1093
EP 1098
DI 10.1093/ntr/ntp106
PG 6
WC Substance Abuse; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Substance Abuse; Public, Environmental & Occupational Health
GA 483ZQ
UT WOS:000269012700009
PM 19596726
DA 2025-06-11
ER

PT J
AU Ferreira, LDM
   Fisberg, RM
   Sarti, FM
   Rogero, MM
AF Ferreira, Leticia do Nascimento Maximiano
   Fisberg, Regina Mara
   Sarti, Flavia Mori
   Rogero, Marcelo Macedo
TI Association between Inflammatory and Metabolic Biomarkers and Common
   Mental Disorders among Adults: 2015 Health Survey of São Paulo, SP,
   Brazil
SO METABOLITES
LA English
DT Article
DE common mental disorders; inflammatory biomarkers; C-reactive protein;
   cardiometabolic biomarkers; metabolic syndrome
ID RECEPTOR; DEPRESSION; RESISTANCE; VALIDITY; UPDATE; DIET; CARE
AB Recent studies suggest that plasma inflammatory biomarker concentrations may represent valuable indicators for the diagnosis and prognosis of mental disorders. At the same time, metabolic alterations may contribute to the development and progression of systemic low-grade inflammation. Background/Objectives: This study evaluated the association between plasma inflammatory biomarkers and common mental disorders (CMD), exploring the relationship between metabolic biomarkers, metabolic syndrome (MetS), and inflammatory biomarkers in younger and older adults. Methods: This cross-sectional study used data from the 2015 Health Survey of S & atilde;o Paulo with a Focus on Nutrition Study. The occurrence of CMD was assessed through the Self-Reporting Questionnaire (SRQ-20). Blood samples were used to measure plasma concentrations of inflammatory and cardiometabolic biomarkers. MetS was defined according to the International Diabetes Federation Consensus. The Mann-Whitney test compared inflammatory biomarker concentrations across CMD groups and cardiometabolic conditions, and logistic regression models explored associations between inflammatory biomarker concentration and CMD. Results: The sample included 575 participants, 22.6% (n = 130) of whom had CMD. Concentrations of plasminogen activator inhibitor 1, C-reactive protein (CRP), and the systemic low-grade inflammation score varied significantly among CMD groups. CRP concentrations were positively associated with the presence of CMD, independent of confounding factors. Participants with insulin resistance, dyslipidemia, and MetS exhibited significantly higher CRP concentrations than individuals without these conditions. Conclusions: The findings suggest that increased plasma CRP concentrations may be a potential risk factor for CMD. Higher CRP concentrations were observed in individuals with insulin resistance, dyslipidemia, and MetS. Future interventional studies should explore these hypotheses in diverse populations.
C1 [Ferreira, Leticia do Nascimento Maximiano; Fisberg, Regina Mara; Rogero, Marcelo Macedo] Univ Sao Paulo, Sch Publ Hlth, Dept Nutr, 715 Dr Arnaldo Ave, BR-01246904 Sao Paulo, SP, Brazil.
   [Sarti, Flavia Mori] Univ Sao Paulo, Sch Arts Sci & Humanities, 1000 Arlindo Bettio Ave, BR-03828000 Sao Paulo, SP, Brazil.
C3 Universidade de Sao Paulo; Universidade de Sao Paulo
RP Rogero, MM (corresponding author), Univ Sao Paulo, Sch Publ Hlth, Dept Nutr, 715 Dr Arnaldo Ave, BR-01246904 Sao Paulo, SP, Brazil.
EM leticia.nascimento.ferreira@usp.br; rfisberg@usp.br; flamori@usp.br;
   mmrogero@usp.br
RI Rogero, Marcelo/F-6246-2012; Fisberg, Regina/Q-6494-2019; Fisberg,
   Regina/C-4069-2012; Sarti, Flavia/D-4767-2009
OI Fisberg, Regina/0000-0002-4490-9035; Macedo Rogero,
   Marcelo/0000-0003-0517-1645; Sarti, Flavia/0000-0003-2834-2005
FU Sao Paulo Municipal Health Department [2013-0.235.936-0]; Research
   Support Foundation of the State of Sao Paulo (FAPESP) [2017/05125-7,
   2022/09577-8]; National Council for Scientific and Technological
   Development (CNPq) [402674/2016-2]
FX This research was funded by the Sao Paulo Municipal Health Department
   [grant number #2013-0.235.936-0]; Research Support Foundation of the
   State of Sao Paulo (FAPESP) [grant number #2017/05125-7 #2022/09577-8];
   and National Council for Scientific and Technological Development (CNPq)
   [grant number #402674/2016-2].
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NR 55
TC 0
Z9 0
U1 0
U2 1
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2218-1989
J9 METABOLITES
JI Metabolites
PD OCT
PY 2024
VL 14
IS 10
AR 535
DI 10.3390/metabo14100535
PG 13
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA K2V6P
UT WOS:001342510300001
PM 39452916
OA gold
DA 2025-06-11
ER

PT J
AU Yildirim, Z
   Sanlier, N
AF Yildirim, Zeyneb
   Sanlier, Nevin
TI The Relationship of Certain Diseases and Dietary Inflammatory Index in
   Older Adults: A Narrative Review
SO CURRENT NUTRITION REPORTS
LA English
DT Review
DE Dietary Inflammatory Index; Inflammation; Anti-inflammatory;
   Proinflammatory; Chronic disease
ID SQUAMOUS-CELL CANCER; BONE-MINERAL DENSITY; DEPRESSIVE SYMPTOMS;
   POSTMENOPAUSAL WOMEN; MEDITERRANEAN DIET; METABOLIC SYNDROME; RISK;
   ASSOCIATION; HEALTH; FRACTURE
AB Purpose of ReviewOne of the important markers affecting aging processes is the increase in inflammatory markers. Many chronic diseases are associated with inflammation and chronic inflammation increases with aging. Inflammation can change with dietary components. Foods, compounds and nutrients that have anti-inflammatory or proinflammatory properties attract attention. According to the Dietary Inflammatory Index, positive scores are obtained if the nutrient has a proinflammatory effect on cytokines, and negative scores are obtained if it has an anti-inflammatory effect.Recent FindingsA higher proinflammatory diet is associated with cardiometabolic diseases, neurodegenerative disease, cancers and musculoskeletal health and related mortality. In this study, its relationship with type 2 diabetes mellitus, obesity, metabolic syndrome, musculoskeletal diseases, dementia, depression and cancer, which are more common in older adults and known to be associated with inflammation, was examined.SummaryAlthough studies involving under 65 years old are more prevalent, research involving older adults and Dietary Inflammatory Index (DII) is more limited. It is known that chronic inflammation increases with aging. Diet is one of the factors affecting inflammation. In the light of these investigations, the topics of anti-inflammatory nutrition and DII for the treatment of inflammation-related diseases in older adults are strong and open to development topics of discussion. Despite the significant interest in the potential positive effects of anti-inflammatory nutrition on diseases, contributing to clearer evidence of its protective effects on health necessitates further randomized controlled trials, in vivo, in vitro, cell, animal, human and case-control studies for better risk assessment.
C1 [Yildirim, Zeyneb; Sanlier, Nevin] Ankara Medipol Univ, Sch Hlth Sci, Dept Nutr & Dietet, Ankara, Turkiye.
C3 Ankara Medipol University
RP Sanlier, N (corresponding author), Ankara Medipol Univ, Sch Hlth Sci, Dept Nutr & Dietet, Ankara, Turkiye.
EM nevintekgul@gmail.com
RI Sanlier, Nevin/W-7657-2018
OI Sanlier, Nevin/0000-0001-5937-0485; Yildirim, Zeyneb/0000-0002-7096-4978
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NR 104
TC 1
Z9 1
U1 3
U2 8
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
EI 2161-3311
J9 CURR NUTR REP
JI Curr. Nutr. Rep.
PD DEC
PY 2024
VL 13
IS 4
BP 768
EP 785
DI 10.1007/s13668-024-00566-4
EA SEP 2024
PG 18
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA J2S9D
UT WOS:001304400700001
PM 39230632
DA 2025-06-11
ER

PT J
AU de Mattos, ACMT
   Campos, YS
   Fiorini, VO
   Sab, Y
   Tavares, BL
   Velarde, LGC
   Lima, GAB
   Filho, RAD
AF Musser Tavares de Mattos, Ana Carolina
   Campos, Yuri Sofiati
   Fiorini, Vitoria Oliveira
   Sab, Yasmin
   Tavares, Bruna Landeiro
   Coca Velarde, Luis Guillermo
   Balarini Lima, Giovanna Aparecida
   da Cruz Filho, Rubens Antunes
TI Relationship between sleep disturbances, lipid profile and insulin
   sensitivity in type 1 diabetic patients: a cross-sectional study
SO ARCHIVES OF ENDOCRINOLOGY METABOLISM
LA English
DT Article
DE Sleep apnea, obstructive; diabetes mellitus, type 1; insulin resistance;
   dyslipidemias; extrinsic sleep disorder
ID GLYCEMIC CONTROL; BERLIN QUESTIONNAIRE; PORTUGUESE-LANGUAGE; METABOLIC
   SYNDROME; RESISTANCE; QUALITY; DEPRESSION; VALIDATION; MORTALITY;
   GLUCOSE
AB Objective The consequences of sleep deprivation in type 1 diabetes (T1D) patients are poorly understood. Our aim was to determine how sleep disorders influence lipid profile and insulin sensitivity in T1D patients. Materials and methods This was a cross-sectional study at a public university hospital. Demographic information and medical histories were obtained during regular scheduled visit of T1D patients to the outpatient clinic. Insulin sensitivity was obtained using the estimated glucose disposal rate (eGDR) formula. Sleep quality was assessed using the Pittsburgh Sleep Quality Index, Epworth Sleepiness Scale and Berlin Questionnaire. Results The adult participants (n = 66, 62% women) had a median age of 28.0 years (interquartile range 21.8-33.0). Six patients (9%) had metabolic syndrome according to the International Diabetes Federation criteria. Thirty patients (46%) were considered poor sleepers according to the Pittsburgh Sleep Quality Index. The LDL-c and total cholesterol levels of poor sleepers were higher than those of good sleepers (103 v. 81; p = 0.003 and 178.0 v. 159.5 mg/dL; p = 0.009, respectively). Three patients (4%) were at high risk of obstructive sleep apnea syndrome (OSAS) according to the Berlin Questionnaire. The eGDR was lower in the group of patients with high probability of having OSAS (6.0 v. 9.1 mg.kg(-1).min(-1); p = .03). Conclusions Poor subjective quality of sleep and higher risk of OSAS were correlated with a worsened lipid profile and decreased insulin sensitivity, respectively. Therefore, T1D patients with sleep disturbances might have an increased cardiovascular risk in the future.
C1 [Musser Tavares de Mattos, Ana Carolina; Campos, Yuri Sofiati; Fiorini, Vitoria Oliveira; Sab, Yasmin; Tavares, Bruna Landeiro; Balarini Lima, Giovanna Aparecida; da Cruz Filho, Rubens Antunes] Univ Fed Fluminense UFF, Dept Med Clin, Niteroi, RJ, Brazil.
   [Coca Velarde, Luis Guillermo] Univ Fed Fluminense UFF, Curso Posgrad Ciencias Med, Dept Med Clin, Niteroi, RJ, Brazil.
C3 Universidade Federal Fluminense; Universidade Federal Fluminense
RP de Mattos, ACMT (corresponding author), Univ Fed Fluminense, Setor Posgrad Ciencias Med, Ave Marques do Parana 303,4 Andar, BR-24033900 Niteroi, RJ, Brazil.
EM ana_musser@hotmail.com
RI Filho, Rubens/K-1837-2015
OI Velarde, Luis Guillermo Coca/0000-0003-3110-5270; Antunes da Cruz Filho,
   Rubens/0000-0002-5083-4543; Sofiati Campos, Yuri/0000-0001-8185-9850
FU Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior Brasil
   (Capes) [001]
FX This study was financed in part by the Coordenacao de Aperfeicoamento de
   Pessoal de Nivel Superior Brasil (Capes) - Finance Code 001.
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   van Dijk M, 2011, DIABETOLOGIA, V54, P1967, DOI 10.1007/s00125-011-2184-7
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NR 35
TC 12
Z9 13
U1 0
U2 5
PU SBEM-SOC BRASIL ENDOCRINOLOGIA & METABOLOGIA
PI RIO DE JANEIRO, RJ
PA RUA HUMAITA, 85 CJ 501, RIO DE JANEIRO, RJ, 22261-000, BRAZIL
SN 2359-3997
EI 2359-4292
J9 ARCH ENDOCRIN METAB
JI Arch. Endocrinol. Metab.
PD JUL-AUG
PY 2020
VL 64
IS 4
BP 412
EP 417
DI 10.20945/2359-3997000000228
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA NB3UL
UT WOS:000560441400013
PM 32267356
OA gold
DA 2025-06-11
ER

PT J
AU Guedes, EP
   Madeira, E
   Mafort, TT
   Madeira, M
   Moreira, RO
   de Mendonça, LMC
   de Godoy-Matos, AF
   Lopes, AJ
   Farias, MLF
AF Guedes, Erika Paniago
   Madeira, Eduardo
   Mafort, Thiago Thomaz
   Madeira, Miguel
   Moreira, Rodrigo Oliveira
   Carvalho de Mendonca, Laura Maria
   de Godoy-Matos, Amelio Fernando
   Lopes, Agnaldo Jose
   Fleiuss Farias, Maria Lucia
TI Impact of 6 months of treatment with intragastric balloon on body fat
   and quality of life in obese individuals with metabolic syndrome
SO HEALTH AND QUALITY OF LIFE OUTCOMES
LA English
DT Article
DE Obesity; Health-related quality of life; Body composition; Intragastric
   balloon
ID BARIATRIC SURGERY; ASSOCIATION; WEIGHT; DEPRESSION; OVERWEIGHT; ADULTS
AB Background: Obesity is a worldwide public health issue with a negative impact on quality of life. Different weight loss interventions have demonstrated improvements in quality of life. The aim of this study was to investigate the effect of 6 months of treatment with an intragastric balloon (IGB) on health-related quality of life (HRQOL) and its relation to changes in body fat in obese individuals with metabolic syndrome (MS).
   Methods: Fifty obese patients with MS aged 18-50 were selected for treatment with IGB for 6 months. Body fat was assessed with anthropometric measures and dual-energy X-ray absorptiometry (DXA) at baseline and after removal of the IGB. HRQOL was evaluated with the short form of the World Health Organization Quality of Life (WHOQOL-BREF) at baseline and soon after removal of the IGB.
   Results: Thirty-nine patients completed the study. After 6 months, there was a significant improvement in quality of life (p = 0.0009) and health (p < 0.0001) perceptions, and in the Physical (p = 0.001), Psychological (p = 0.031), and Environmental domains (p = 0.0071). Anthropometric measures and total fat determined by DXA were directly and significantly related to an improvement in general aspects of quality of life. The decrease in the percentage of total fat was the parameter that better correlated with improvements in quality of life perception after regression (p = 0.032).
   Conclusions: In obese individuals with MS, weight loss parameters were associated with short-term improvements in HRQOL after 6 months of treatment with IGB. However, only total fat was independently related to HRQOL perception.
C1 [Guedes, Erika Paniago; Moreira, Rodrigo Oliveira; de Godoy-Matos, Amelio Fernando] State Inst Diabet & Endocrinol IEDE, Div Metabol, Ave Amer,2901,Sala 305, BR-22631001 Rio De Janeiro, RJ, Brazil.
   [Madeira, Eduardo] Univ Estado Rio De Janeiro, Div Gastroenterol, Rio De Janeiro, Brazil.
   [Mafort, Thiago Thomaz; Lopes, Agnaldo Jose] Univ Estado Rio De Janeiro, Div Pneumol, Rio De Janeiro, Brazil.
   [Guedes, Erika Paniago; Madeira, Eduardo; Madeira, Miguel; Moreira, Rodrigo Oliveira; Fleiuss Farias, Maria Lucia] Univ Fed Rio de Janeiro, Div Endocrinol, Rio De Janeiro, Brazil.
   [Carvalho de Mendonca, Laura Maria] Univ Fed Rio de Janeiro, Div Rheumatol, Rio De Janeiro, Brazil.
C3 Universidade do Estado do Rio de Janeiro; Universidade do Estado do Rio
   de Janeiro; Universidade Federal do Rio de Janeiro; Universidade Federal
   do Rio de Janeiro
RP Guedes, EP (corresponding author), State Inst Diabet & Endocrinol IEDE, Div Metabol, Ave Amer,2901,Sala 305, BR-22631001 Rio De Janeiro, RJ, Brazil.; Guedes, EP (corresponding author), Univ Fed Rio de Janeiro, Div Endocrinol, Rio De Janeiro, Brazil.
EM erikapaniago@uol.com.br
RI Lopes, Agnaldo/B-6430-2016; Moreira, Rodrigo/N-7131-2015; Lopes, Agnaldo
   Jose/AAB-5944-2019
OI Lopes, Agnaldo Jose/0000-0001-8598-4878; Guedes,
   ERIKA/0000-0003-4430-8069
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NR 37
TC 8
Z9 9
U1 0
U2 10
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1477-7525
J9 HEALTH QUAL LIFE OUT
JI Health Qual. Life Outcomes
PD OCT 24
PY 2017
VL 15
AR 211
DI 10.1186/s12955-017-0790-x
PG 6
WC Health Care Sciences & Services; Health Policy & Services
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services
GA FK6FK
UT WOS:000413598500001
PM 29065923
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Snyder, S
   Turner, GA
   Turner, A
AF Snyder, Samuel
   Turner, Gracie A.
   Turner, Alan
TI Obesity-related Kidney Disease
SO PRIMARY CARE
LA English
DT Article
DE Obesity; Kidney; Hypertension; Insulin resistance; Inflammation
ID ANGIOTENSIN-CONVERTING ENZYME; INSULIN-RESISTANCE; OXIDATIVE STRESS;
   INSERTION/DELETION POLYMORPHISM; GENE POLYMORPHISMS; METABOLIC SYNDROME;
   EMERGING EPIDEMIC; NATIONAL-HEALTH; BLOOD-PRESSURE; RENAL-FUNCTION
AB The prevalence of chronic kidney disease (CKD) is increasing, and the epidemic of obesity is one of the causes. Obesity exacerbates hypertension as a risk factor for CKD, causing vasoconstriction and salt and water retention. Obesity also worsens glucose intolerance and insulin resistance as risk factors for CKD. Obesity targets the kidney by triggering novel pathways of intrarenal inflammation, recruiting professional immunologic cells through metaflammation. Obesity-related glomerulopathy has emerged as a distinct pathologic variant of focal segmental glomerulosclerosis. No definitive treatments have come about for obesity-related glomerulopathy, but among the most promising prospects is aggressive weight loss, including bariatric surgery.
C1 [Snyder, Samuel] Nova SE Univ, Ft Lauderdale, FL 33328 USA.
C3 Nova Southeastern University
RP Snyder, S (corresponding author), Nova SE Univ, 3200 S Univ Dr, Ft Lauderdale, FL 33328 USA.
EM snyderdo@nova.edu
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NR 98
TC 20
Z9 23
U1 0
U2 27
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0095-4543
EI 1558-299X
J9 PRIMARY CARE
JI Primary Care
PD DEC
PY 2014
VL 41
IS 4
BP 875
EP +
DI 10.1016/j.pop.2014.08.008
PG 20
WC Primary Health Care; Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA AU7WZ
UT WOS:000345810400012
PM 25439539
DA 2025-06-11
ER

PT J
AU Tillett, W
   Ogdie, A
   Passey, A
   Gorecki, P
AF Tillett, William
   Ogdie, Alexis
   Passey, Alun
   Gorecki, Patricia
TI Impact of psoriatic arthritis and comorbidities on ustekinumab outcomes
   in psoriasis: a retrospective, observational BADBIR cohort study
SO RMD OPEN
LA English
DT Article
DE arthritis; psoriatic; biological therapy; therapeutics
ID DISEASE
AB ObjectivesPsoriasis and psoriatic arthritis (PsA) are independently associated with comorbidities, including obesity and metabolic syndrome, which may impact treatment outcomes. This study aimed to assess baseline differences between patients with plaque psoriasis alone and those with concomitant PsA, and to investigate the impact of these characteristics on ustekinumab (UST) persistence and outcomes.Methods9057 patients receiving UST or conventional systemic disease-modifying antirheumatic drugs were selected from the British Association of Dermatologists Biologic and Immunomodulators Register. The psoriasis and PsA cohorts were compared at baseline. Time to discontinuation during 10-year follow-up was assessed using multivariable Cox regression and Kaplan-Meier analyses, stratifying for interacting covariates and PsA status. Generalised linear mixed models assessed the impact of baseline characteristics on Psoriasis Area and Severity Index (PASI) and Dermatology Life Quality Index over time.ResultsGreater comorbidity burden, including hypertension, diabetes, obesity and depression, and greater inability to work were observed in the PsA cohort than in the psoriasis cohort. PsA (HR 1.98), female sex (HR for male sex 0.72) and depression (HR 1.21) were associated with shorter UST persistence. PsA showed a differential association with UST persistence by PASI strata and prior biologic exposure. Quality of life was negatively impacted by depression and PsA.ConclusionsThe negative impact of comorbidities on treatment persistence identified in this study emphasises the need for patient-centric, multidisciplinary care in screening for and managing comorbidities in psoriasis and PsA treatment. Psychological support and lifestyle management of modifiable risk factors, including obesity, should be considered.
C1 [Tillett, William] Royal Natl Hosp Rheumat Dis, Dept Rheumatol, Bath, England.
   [Tillett, William] Univ Bath, Dept Life Sci, Bath, England.
   [Ogdie, Alexis] Univ Penn, Perelman Sch Med, Div Rheumatol, Philadelphia, PA USA.
   [Passey, Alun; Gorecki, Patricia] Janssen Cilag Ltd, High Wycombe, England.
C3 Royal National Hospital for Rheumatic Diseases (RNHRD); University of
   Bath; University of Pennsylvania; Johnson & Johnson; Johnson & Johnson
   United Kingdom
RP Tillett, W (corresponding author), Royal Natl Hosp Rheumat Dis, Dept Rheumatol, Bath, England.; Tillett, W (corresponding author), Univ Bath, Dept Life Sci, Bath, England.
OI Tillett, William/0000-0001-7531-4125
FU Janssen-Cilag Ltd
FX This work was supported by Janssen-Cilag Ltd.
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NR 33
TC 2
Z9 2
U1 1
U2 1
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2056-5933
J9 RMD OPEN
JI RMD Open
PD JAN
PY 2023
VL 9
IS 1
AR e002533
DI 10.1136/rmdopen-2022-002533
PG 9
WC Rheumatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Rheumatology
GA 8A9IF
UT WOS:000916546200001
PM 36650006
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Moisan, MP
   Castanon, N
AF Moisan, Marie-Pierre
   Castanon, Nathalie
TI Emerging Role of Corticosteroid-Binding Globulin in
   Glucocorticoid-Driven Metabolic Disorders
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Review
DE glucocorticoids; transcortin; obesity; metabolism; lipid storage
ID RESPONSIVE ADRENOCORTICAL AXIS; INSULIN-RESISTANCE SYNDROME;
   QUANTITATIVE TRAIT LOCI; DEFICIENT MALE-MICE; OBESE ZUCKER RATS;
   GROWTH-FACTOR-I; STRESS RESPONSES; MEAT QUALITY; LARGE WHITE; CORTISOL
AB Glucocorticoid hormones (GCs) are critical for survival since they ensure the energy supply necessary to the body in an ever challenging environment. GCs are known to act on appetite, glucose metabolism, fatty acid metabolism, and storage. However, to be beneficial to the body, GC levels should be maintained in an optimal window of concentrations. Not surprisingly, conditions of GC excess or deficiency, e. g., Cushing's syndrome or Addison's disease, are associated with severe alterations of energy metabolism. Corticosteroid-binding globulin (CBG), through its high specific affinity for GCs, plays a critical role in regulating plasma GC levels and their access to target cells. Genetic studies in various species including humans have revealed that CBG is the major factor influencing interindividual genetic variability of plasma GC levels, both in basal and stress conditions. Some, but not all, of these genetic studies have also provided data linking CBG levels to body composition and insulin levels. The examination of CBG-deficient mice submitted to hyperlipidic diets unveiled specific roles for CBG in lipid storage and metabolism. An influence of CBG on appetite has not been reported but remains to be more finely analyzed. Finally, only male mice have been examined under high-fat diet, while obesity is affecting women even more than men. Overall, a role of CBG in GC-driven metabolic disorders is emerging in recent studies. Although subtle, the influence of CBG in these diseases could open the way to new therapeutic interventions since CBG is easily accessible in the blood.
C1 [Moisan, Marie-Pierre; Castanon, Nathalie] INRA, Nutr & Integrat Neurobiol NutrINeurO, UMR 1286, Bordeaux, France.
   [Moisan, Marie-Pierre; Castanon, Nathalie] Univ Bordeaux, Nutr & Integrat Neurobiol NutrINeurO, Bordeaux, France.
C3 Institut National de la Sante et de la Recherche Medicale (Inserm);
   Universite de Bordeaux; INRAE; Universite de Bordeaux
RP Moisan, MP (corresponding author), INRA, Nutr & Integrat Neurobiol NutrINeurO, UMR 1286, Bordeaux, France.; Moisan, MP (corresponding author), Univ Bordeaux, Nutr & Integrat Neurobiol NutrINeurO, Bordeaux, France.
EM mare-pierre.moisan@inra.fr
RI Moisan, Marie-Pierre/AAO-9971-2021
OI Castanon, Nathalie/0000-0002-0079-0562; Moisan,
   Marie-Pierre/0000-0001-7315-5319
FU INRA; Conseil Regional d'Aquitaine [2013 13 03 001]
FX Studies from the authors' lab were funded by INRA and Conseil Regional
   d'Aquitaine grant# 2013 13 03 001.
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NR 41
TC 9
Z9 9
U1 1
U2 26
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA PO BOX 110, EPFL INNOVATION PARK, BUILDING I, LAUSANNE, 1015,
   SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD DEC 19
PY 2016
VL 7
AR 160
DI 10.3389/fendo.2016.00160
PG 5
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA EE9NC
UT WOS:000389952400001
PM 28066325
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Kuzawa, CW
   Sweet, E
AF Kuzawa, Christopher W.
   Sweet, Elizabeth
TI Epigenetics and the Embodiment of Race: Developmental Origins of US
   Racial Disparities in Cardiovascular Health
SO AMERICAN JOURNAL OF HUMAN BIOLOGY
LA English
DT Review
ID LOW-BIRTH-WEIGHT; ISCHEMIC-HEART-DISEASE; INSULIN-RESISTANCE SYNDROME;
   IMPAIRED GLUCOSE-TOLERANCE; BLOOD-PRESSURE; AFRICAN-AMERICAN;
   LIFE-COURSE; FOREIGN-BORN; INFANT-MORTALITY; GESTATIONAL-AGE
AB The relative contribution of genetic and environmental influences to the US black-white disparity in cardiovascular disease (CVD) is hotly debated within the public health, anthropology, and medical communities. In this article, we review evidence for developmental and epigenetic pathways linking early life environments with CVD, and critically evaluate their possible role in the origins of these racial health disparities. African Americans not only suffer from a disproportionate burden of CVD relative to whites, but also have higher rates of the perinatal health disparities now known to be the antecedents of these conditions. There is extensive evidence for a social origin to prematurity and low birth weight in African Americans, reflecting pathways such as the effects of discrimination on maternal stress physiology. In light of the inverse relationship between birth weight and adult CVD, there is now a strong rationale to consider developmental and epigenetic mechanisms as links between early life environmental factors like maternal stress during pregnancy and adult race-based health disparities in diseases like hypertension, diabetes, stroke, and coronary heart disease. The model outlined here builds upon social constructivist perspectives to highlight an important set of mechanisms by which social influences can become embodied, having durable and even transgenerational influences on the most pressing US health disparities. We conclude that environmentally responsive phenotypic plasticity, in combination with the better-studied acute and chronic effects of social-environmental exposures, provides a more parsimonious explanation than genetics for the persistence of CVD disparities between members of socially imposed racial categories. Am. J. Hum. Biol. 21:2-15, 2009. (C) 2008 Wiley-Liss, Inc.
C1 [Kuzawa, Christopher W.; Sweet, Elizabeth] Northwestern Univ, Dept Anthropol, Evanston, IL 60208 USA.
C3 Northwestern University
RP Kuzawa, CW (corresponding author), Northwestern Univ, Dept Anthropol, 1810 Hinman Ave, Evanston, IL 60208 USA.
EM kuzawa@northwestern.edu
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NR 238
TC 472
Z9 586
U1 2
U2 146
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1042-0533
EI 1520-6300
J9 AM J HUM BIOL
JI Am. J. Hum. Biol.
PD JAN-FEB
PY 2009
VL 21
IS 1
BP 2
EP 15
DI 10.1002/ajhb.20822
PG 14
WC Anthropology; Biology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Anthropology; Life Sciences & Biomedicine - Other Topics
GA 387EJ
UT WOS:000261934200002
PM 18925573
DA 2025-06-11
ER

PT J
AU Bagherian-Sararoudi, R
   Sanei, H
   Attari, A
   Afshar, H
AF Bagherian-Sararoudi, Reza
   Sanei, Hamid
   Attari, Abass
   Afshar, Hamid
TI Type D personality is associated with hyperlipidemia in patients with
   myocardial infarction
SO JOURNAL OF RESEARCH IN MEDICAL SCIENCES
LA English
DT Article
DE Hyperlipidemia; negative affectivity; psychological factors; social
   inhibition; type D personality
ID MAJOR DEPRESSIVE DISORDER; METABOLIC SYNDROME; LIPID CONCENTRATIONS;
   CORTISOL; RISK; STRESS; WOMEN; HEART; SYMPTOMS; ANXIETY
AB Objective: There are many studies indicating the role of psychological factors in the pathogenesis of cardiovascular disorders. Type D as a new personality construct has been proposed by Denollet, characterized by the joint global traits including negative affectivity and social inhibition. The purpose of this study was to examine the link between type D personality and hyperlipidemia in patients with myocardial infarction (MI). Materials and Methods: One hundred and seventy-six consecutive patients admitted to the cardiac care unit (CCU) wards of nine hospitals in Isfahan, Iran, following MI, were selected based on the inclusive and exclusive criteria. The patients completed demographic questionnaire and Type D Personality Scale (DS14). Their medical data were obtained from medical records. Chi-squared test, Student's t-test, and multivariate logistic regression were used to analyze the data. Results: Of the 176 subjects, 63 patients (35.8%) were type D. In univariate analysis, hyperlipidemia was the only significant variable (56% vs. 40%, P = 0.041) found to be associated with type D. Also, by multivariable logistic regression analysis, hyperlipidemia [Odds Ratio (OR) 0.374; 95% confidence interval (CI) 0.175-0.796] was the only independently significant variable found to be linked with type D personality. No other statistically significant differences were found between the two groups on demographic and medical factors characteristics. Conclusion: The type D personality was associated with hyperlipidemia. Thus, personality factors may make people vulnerable to metabolic syndromes.
C1 [Bagherian-Sararoudi, Reza; Attari, Abass] Isfahan Univ Med Sci, Behav Sci Res Ctr, Sch Med, Esfahan, Iran.
   [Bagherian-Sararoudi, Reza; Attari, Abass] Isfahan Univ Med Sci, Dept Psychiat, Sch Med, Esfahan, Iran.
   [Sanei, Hamid] Isfahan Univ Med Sci, Dept Internal Med, Sch Med, Esfahan, Iran.
   [Afshar, Hamid] Isfahan Univ Med Sci, Psychosomat Res Ctr, Esfahan, Iran.
C3 Isfahan University of Medical Sciences; Isfahan University of Medical
   Sciences; Isfahan University of Medical Sciences; Isfahan University of
   Medical Sciences
RP Bagherian-Sararoudi, R (corresponding author), Isfahan Univ Med Sci, Behav Sci Res Ctr, Sch Med, Esfahan, Iran.
EM bagherian@med.mui.ac.ir
RI Sanei, Hamid/B-7682-2018; Attari, Abbas/W-4188-2017
OI Attari, Abbas/0000-0002-6204-8531; Sanei, Hamid/0000-0002-3671-8220
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NR 32
TC 10
Z9 10
U1 0
U2 4
PU ISFAHAN UNIV MED SCIENCES
PI ISFAHAN
PA HEZARJERIB AVE, PO BOX 81745-319, ISFAHAN, 00000, IRAN
SN 1735-1995
J9 J RES MED SCI
JI J. Res. Med. Sci.
PD JUN
PY 2012
VL 17
IS 6
BP 543
EP 547
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 997QW
UT WOS:000308182200009
PM 23626631
DA 2025-06-11
ER

PT J
AU Adams, LA
   Angulo, P
AF Adams, LA
   Angulo, P
TI Treatment of non-alcoholic fatty liver disease
SO POSTGRADUATE MEDICAL JOURNAL
LA English
DT Review
ID VITAMIN-E TREATMENT; HEPATIC STEATOSIS; FOLLOW-UP; URSODEOXYCHOLIC ACID;
   INSULIN-RESISTANCE; NATURAL-HISTORY; WEIGHT-LOSS; METABOLIC SYNDROME;
   RANDOMIZED-TRIAL; SEVERELY OBESE
AB Non-alcoholic fatty liver disease (NAFLD) is common and may progress to cirrhosis and its complications. The pathogenesis of steatosis and cellular injury is thought to be related mostly to insulin resistance and oxidative stress. Therefore, management entails identification and treatment of metabolic risk factors, improving insulin sensitivity, and increasing antioxidant defences in the liver. Weight loss and exercise improve insulin sensitivity. Bariatric surgery may improve liver histology in patients with morbid obesity. Insulin sensitising drugs showed promise in pilot trials as have a number of hepatoprotective agents. Further randomised, well controlled trials are required to determine the efficacy of these drugs.
C1 Mayo Clin Coll Med, Div Gastroenterol & Hepatol, Rochester, MN 55905 USA.
   Univ Western Australia, Fremantale Hosp, Sch Med Pharmacol, Perth, WA, Australia.
C3 Mayo Clinic; University of Western Australia
RP Mayo Clin Coll Med, Div Gastroenterol & Hepatol, 200 1st St SW, Rochester, MN 55905 USA.
EM angulo-hernandez.paul@mayo.edu
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NR 97
TC 192
Z9 225
U1 0
U2 17
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 0032-5473
EI 1469-0756
J9 POSTGRAD MED J
JI Postgrad. Med. J.
PD MAY
PY 2006
VL 82
IS 967
BP 315
EP 322
DI 10.1136/pgmj.2005.042200
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 039WD
UT WOS:000237337500005
PM 16679470
OA Bronze, Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Tabrizi, R
   Tamtaji, OR
   Lankarani, KB
   Mirhosseini, N
   Akbari, M
   Dadgostar, E
   Peymani, P
   Asemi, Z
AF Tabrizi, Reza
   Tamtaji, Omid Reza
   Lankarani, Kamran B.
   Mirhosseini, Naghmeh
   Akbari, Maryam
   Dadgostar, Ehsan
   Peymani, Payam
   Asemi, Zatollah
TI The effects of resveratrol supplementation on biomarkers of inflammation
   and oxidative stress among patients with metabolic syndrome and related
   disorders: a systematic review and meta-analysis of randomized
   controlled trials
SO FOOD & FUNCTION
LA English
DT Review
ID C-REACTIVE PROTEIN; BLOOD MONONUCLEAR-CELLS; CLINICAL-TRIAL;
   CARDIOVASCULAR-DISEASE; INSULIN SENSITIVITY; PRIMARY PREVENTION;
   GENE-EXPRESSION; DOUBLE-BLIND; IMPROVES; GLUCOSE
AB There are several current trials investigating the effect of resveratrol supplementation on biomarkers of inflammation and oxidative stress among patients with metabolic syndrome (MetS); however, their findings are controversial. This systematic review and meta-analysis of randomized controlled trials (RCTs) were conducted to summarize the existing evidence and collectively determine the effects of resveratrol supplementation on biomarkers of inflammation and oxidative stress among patients with MetS and related disorders. Two authors independently searched electronic databases, including MEDLINE, EMBASE, Cochrane Library, and Web of Science databases, until May 2018 in order to find relevant RCTs. The quality of the selected RCTs was evaluated using the Cochrane Collaboration risk of bias tool. Cochran's Q test and I-square (I-2) statistic were used to determine whether heterogeneity exists across included trials. Standardized mean difference (SMD) and 95% CI between two intervention groups were used to determine pooled effect sizes. Out of 317 potential citations selected based on keywords, 24 RCTs met the inclusion criteria and were eligible for the current meta-analysis. The pooled results obtained by using the random-effects model showed that resveratrol supplementation significantly decreased C-reactive protein (CRP) (SMD = -0.55; 95% CI, -0.84, -0.26; P < 0.001; I-2: 84.0) and tumor necrosis factor- (TNF-) (SMD = -0.68; 95% CI, -1.08, -0.28; P = 0.001; I-2: 81.3) concentrations among patients with MetS and related disorders. Interleukin 6 (IL-6) (SMD = 0.05; 95% CI, -0.31, 0.41; P = 0.79; I-2: 85.0) and superoxide dismutase (SOD) (SMD = 0.21; 95% CI, -3.16, 3.59; P = 0.90; I-2: 97.7) concentrations did not significantly change following resveratrol supplementation. Resveratrol supplementation showed a promising lowering effect on some of the inflammatory markers among patients with MetS and related disorders. Additional prospective studies regarding the effect of resveratrol supplementation on biomarkers of inflammation and oxidative stress by using higher doses of resveratrol and longer duration of supplementation are necessary.
C1 [Tabrizi, Reza; Akbari, Maryam] Shiraz Univ Med Sci, Inst Hlth, Hlth Policy Res Ctr, Student Res Comm, Shiraz, Iran.
   [Tamtaji, Omid Reza] Kashan Univ Med Sci, Physiol Res Ctr, Kashan, Iran.
   [Lankarani, Kamran B.; Peymani, Payam] Shiraz Univ Med Sci, Inst Hlth, Hlth Policy Res Ctr, Shiraz, Iran.
   [Mirhosseini, Naghmeh] Pure North Senergy Fdn, Calgary, AB, Canada.
   [Dadgostar, Ehsan] FDA, Halal Res Ctr IRI, Tehran, Iran.
   [Asemi, Zatollah] Kashan Univ Med Sci, Res Ctr Biochem & Nutr Metab Dis, Kashan, Iran.
C3 Shiraz University of Medical Science; Shiraz University of Medical
   Science
RP Asemi, Z (corresponding author), Kashan Univ Med Sci, Res Ctr Biochem & Nutr Metab Dis, Kashan, Iran.
EM asemi_r@yahoo.com
RI Akbari, Ali/G-6044-2016; tamtaji, M/KWU-3655-2024; Lankarani,
   Kamran/P-5336-2019; peymani, payam/S-7386-2017; Mirhosseini,
   Naghmeh/AAC-7730-2019; asemi, zatollah/J-2677-2018; Asemi,
   Zatollah/G-7393-2017
OI Asemi, Zatollah/0000-0001-5265-4792; dadgostar,
   ehsan/0000-0002-4041-7324; Tamtaji, Omid Reza/0000-0003-2492-3996;
   tabrizi, reza/0000-0001-7634-3948
FU SUMS, Shiraz, and Iran [97-01-106-17382]
FX The present study was supported by a grant number 97-01-106-17382 from
   the Vice-chancellor for Research, SUMS, Shiraz, and Iran.
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NR 51
TC 33
Z9 34
U1 0
U2 10
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PD DEC 1
PY 2018
VL 9
IS 12
BP 6117
EP 6129
DI 10.1039/c8fo01259h
PG 13
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA HE3HP
UT WOS:000453244900004
PM 30426122
DA 2025-06-11
ER

PT J
AU Green, DM
   Lahiri, T
   Raraigh, KS
   Ruiz, F
   Spano, J
   Antos, N
   Bonitz, L
   Christon, L
   Gregoire-Bottex, M
   Hale, JE
   Langfelder-Schwind, E
   Perez, AL
   Maguiness, K
   Massie, J
   McElroy-Barker, E
   McGarry, ME
   Mercier, A
   Munck, A
   Oliver, KE
   Self, S
   Singh, K
   Smiley, M
   Snodgrass, S
   Tluczek, A
   Tuley, P
   Lomas, P
   Wong, E
   Hempstead, SE
   Faro, A
   Ren, CL
AF Green, Deanna M.
   Lahiri, Thomas
   Raraigh, Karen S.
   Ruiz, Fadel
   Spano, Jacquelyn
   Antos, Nicholas
   Bonitz, Lynn
   Christon, Lillian
   Gregoire-Bottex, Myrtha
   Hale, Jaime E.
   Langfelder-Schwind, Elinor
   Perez, Alvaro La Parra
   Maguiness, Karen
   Massie, John
   McElroy-Barker, Erin
   McGarry, Meghan E.
   Mercier, Angelique
   Munck, Anne
   Oliver, Kathryn E.
   Self, Staci
   Singh, Kathryn
   Smiley, Michael
   Snodgrass, Steven
   Tluczek, Audrey
   Tuley, Pamela
   Lomas, Paula
   Wong, Elise
   Hempstead, Sarah E.
   Faro, Albert
   Ren, Clement L.
TI Cystic Fibrosis Foundation Evidence-Based Guideline for the Management
   of CRMS/CFSPID
SO PEDIATRICS
LA English
DT Article
ID INCONCLUSIVE DIAGNOSIS; METABOLIC SYNDROME; INFECTION PREVENTION;
   CLINICAL-OUTCOMES; CFTR; INFANTS; CHILDREN; IDENTIFICATION; DEPRESSION;
   EXPERIENCE
AB A multidisciplinary committee developed evidence-based guidelines for the management of cystic fibrosis transmembrane conductance regulator-related metabolic syndrome/cystic fibrosis screen-positive, inconclusive diagnosis (CRMS/CFSPID). A total of 24 patient, intervention, comparison, and outcome questions were generated based on surveys sent to people with CRMS/CFSPID and clinicians caring for these individuals, previous recommendations, and expert committee input. Four a priori working groups (genetic testing, monitoring, treatment, and psychosocial/communication issues) were used to provide structure to the committee. A systematic review of the evidence was conducted, and found numerous case series and cohort studies, but no randomized clinical trials. A total of 30 recommendations were graded using the US Preventive Services Task Force methodology. Recommendations that received >= 80% consensus among the entire committee were approved. The resulting recommendations were of moderate to low certainty for the majority of the statements because of the low quality of the evidence. Highlights of the recommendations include thorough evaluation with genetic sequencing, deletion/duplication analysis if <2 disease-causing variants were noted in newborn screening; repeat sweat testing until at least age 8 but limiting further laboratory testing, including microbiology, radiology, and pulmonary function testing; minimal use of medications, which when suggested, should lead to shared decision-making with families; and providing communication with emphasis on social determinants of health and shared decision-making to minimize barriers which may affect processing and understanding of this complex designation. Future research will be needed regarding medication use, antibiotic therapy, and the use of chest imaging for monitoring the development of lung disease.
C1 [Green, Deanna M.] Johns Hopkins All Childrens Hosp, St Petersburg, FL USA.
   [Lahiri, Thomas] Univ Vermont, Childrens Hosp, Burlington, VT USA.
   [Raraigh, Karen S.] Johns Hopkins Univ, Sch Med, Baltimore, MD USA.
   [Ruiz, Fadel] Baylor Coll Med, Houston, TX USA.
   [Spano, Jacquelyn] Texas Childrens Hosp, Houston, TX USA.
   [Antos, Nicholas] Stanford Univ, Sch Med, Stanford, CA USA.
   [Bonitz, Lynn] Med Coll Wisconsin, Childrens Wisconsin, Milwaukee, WI USA.
   [Christon, Lillian] NY Northwell Hlth, Cohen Childrens Med Ctr, New Hyde Pk, NY USA.
   [Gregoire-Bottex, Myrtha] Med Univ South Carolina, Charleston, SC USA.
   [Gregoire-Bottex, Myrtha] Adv Pediat Pulmonol Pllc, Miramar, FL USA.
   [Hale, Jaime E.] Mem Hlth Network, Hollywood, FL USA.
   [Langfelder-Schwind, Elinor] Univ Massachusetts, Chan Med Sch, Worcester, MA USA.
   [Perez, Alvaro La Parra] Northwell Hlth, Lenox Hill Hosp, New York, NY USA.
   [Maguiness, Karen] Weber State Univ, John B Goddard Sch Business & Econ, Ogden, UT 84408 USA.
   [Massie, John] Riley Hosp Children IU Hlth, Indianapolis, IN USA.
   [McElroy-Barker, Erin] Univ Melbourne, Murdoch Childrens Res Inst, Melbourne, Vic, Australia.
   [McGarry, Meghan E.] Rutgers Robert Wood Johnson Med Sch, New Brunswick, NJ USA.
   [Mercier, Angelique] Univ Calif San Francisco, San Francisco, CA USA.
   [Munck, Anne] Northwestern Univ, Robert H Lurie Childrens Hosp Chicago, Feinberg Sch Med, Chicago, IL USA.
   [Oliver, Kathryn E.] Hosp Necker Enfants Malad, AP HP, Paris, France.
   [Self, Staci] Emory Univ, Sch Med, Atlanta, GA USA.
   [Singh, Kathryn] Univ Alabama Birmingham, Birmingham, AL USA.
   [Smiley, Michael] Univ Calif Irvine, Calif Miller Childrens & Womens Hosp, Long Beach, CA USA.
   [Snodgrass, Steven] St Louis Univ, St Louis, MO USA.
   [Tluczek, Audrey] Prisma Hlth Childrens Hosp, Greenville, SC USA.
   [Tuley, Pamela] Univ Wisconsin Madison, Madison, WI USA.
   [Lomas, Paula; Wong, Elise; Hempstead, Sarah E.; Faro, Albert] Cyst Fibrosis Fdn, Bethesda, MD USA.
   [Ren, Clement L.] Childrens Hosp Philadelphia, Philadelphia, PA USA.
C3 Johns Hopkins University; Johns Hopkins Medicine; University of Vermont;
   Johns Hopkins University; Baylor College of Medicine; Baylor College of
   Medicine; Baylor College Medical Hospital; Stanford University;
   Children's Hospital of Wisconsin; Medical College of Wisconsin;
   Northwell Health; North Shore University Hospital; Steven & Alexandra
   Cohen Children's Medical Center of New York; Medical University of South
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RP Green, DM (corresponding author), 601 5th St S Suite 780, St Petersburg, FL 33701, Russia.
EM dgreen50@jhmi.edu
RI Green, Deanna/HGU-5890-2022; Oliver, Kathryn/KJM-8659-2024; Ren,
   Clement/AFW-0625-2022
FU Cystic Fibrosis Foundation
FX This guideline was supported by the Cystic Fibrosis Foundation. The
   sponsor assisted with the application of the committee members and
   resources for weekly and monthly virtual meetings of the committee
   members
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NR 83
TC 9
Z9 9
U1 1
U2 2
PU AMER ACAD PEDIATRICS
PI Itasca
PA 345 Park Boulevard, Itasca, IL, UNITED STATES
SN 0031-4005
EI 1098-4275
J9 PEDIATRICS
JI Pediatrics
PD MAY
PY 2024
VL 153
IS 5
AR e2023064657
DI 10.1542/peds.2023-064657
PG 12
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA A3U3Q
UT WOS:001281812000029
PM 38577740
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Das, SK
   Vail, TA
   Lebrón-Torres, N
   Livingston, KA
   Roberts, SB
   Rogers, GT
   Gilhooly, CH
   Urban, LE
   Saltzman, E
   McKeown, NM
   Folta, SC
AF Das, Sai Krupa
   Vail, Taylor A.
   Lebron-Torres, Namibia
   Livingston, Kara A.
   Roberts, Susan B.
   Rogers, Gail T.
   Gilhooly, Cheryl H.
   Urban, Lorien E.
   Saltzman, Edward
   McKeown, Nicola M.
   Folta, Sara C.
TI Association of nutrition club membership with markers of health: a cross
   sectional study
SO BMC PUBLIC HEALTH
LA English
DT Article
DE Obesity; Nutrition assessment; Metabolic syndrome; Program evaluation;
   Health promotion
ID WEIGHT-LOSS PROGRAMS; QUESTIONNAIRE; RISK; QUALITY; RELIABILITY;
   DEFICIENCY; ADULTS
AB Background: Nutrition clubs (NC) operate in community settings and provide members with nutrition education and meal replacements for weight management. NC are owned and operated by distributors of Herbalife products. There are over 6200 NC in the US, but there has been no independent assessment of the association of these NC with biomarkers of health.
   Methods: We conducted a cross-sectional pilot study to compare the health status of 100 NC members to 100 community-matched controls (CC) in the greater Boston area. Each CC was matched to a NC member for community of residence (zip code), age category, gender, BMI category, race/ethnicity, education level (category), and readiness to make health changes. Measures obtained included cardio-metabolic risk factors, body composition, markers of nutritional status, reported health status, dietary intake, physical activity, sleep and depression.
   Results: Participants were predominantly female (64%) and Hispanic (73%). NC members had significantly lower fasting insulin (P < 0.001) and lower HbA1c (P = 0.008), higher levels of 25 hydroxy-vitamin D (P = 0.001), and vitamin E: cholesterol ratio (P < 0.001), and lower prevalence of metabolic syndrome (P = 0.02) compared to CC. In addition, most of the NC members (99%) were satisfied with Herbalife NC membership for themselves and their families. A higher percentage of NC members (86%) compared to CC (32%) reported being in much better or somewhat better health compared to a year ago (P < 0.001); and they reported significantly better physical health (P = 0.03), and fewer sleep problems (P = 0.03).
   Conclusion: Herbalife NC membership was positively associated with perceived health and measured cardiometabolic benefits. However, causality cannot be inferred from these findings.
C1 [Das, Sai Krupa; Vail, Taylor A.; Lebron-Torres, Namibia; Livingston, Kara A.; Roberts, Susan B.; Rogers, Gail T.; Gilhooly, Cheryl H.; Urban, Lorien E.; McKeown, Nicola M.] Tufts Univ, Jean Mayer USDA Human Nutr Res Ctr Aging, 711 Washington St, Boston, MA 02111 USA.
   [Das, Sai Krupa; Vail, Taylor A.; Lebron-Torres, Namibia; Roberts, Susan B.; Gilhooly, Cheryl H.; Saltzman, Edward; McKeown, Nicola M.; Folta, Sara C.] Tufts Univ, Gerald J Dorothy R Friedman Sch Nutr Sci & Policy, Boston, MA 02111 USA.
C3 Tufts University; United States Department of Agriculture (USDA); Tufts
   University
RP Das, SK (corresponding author), Tufts Univ, Jean Mayer USDA Human Nutr Res Ctr Aging, 711 Washington St, Boston, MA 02111 USA.; Das, SK (corresponding author), Tufts Univ, Gerald J Dorothy R Friedman Sch Nutr Sci & Policy, Boston, MA 02111 USA.
EM Sai.das@tufts.edu
OI Das, SAI KRUPA/0000-0003-0788-0461; Livingston Staffier,
   Kara/0000-0003-0998-1178
FU Herbalife International of America; Tufts University
FX This study was supported by Herbalife International of America through a
   contractual agreement with Tufts University. This agreement allows
   investigators to have independence and responsibility for conducting the
   research presented here. Dr. Das was an invited speaker at an industry
   sponsored symposium organized by Herbalife at the recent European
   Obesity Society Meeting a year after the completion study.
CR [Anonymous], NIH PUBL
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NR 28
TC 0
Z9 0
U1 0
U2 10
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1471-2458
J9 BMC PUBLIC HEALTH
JI BMC Public Health
PD APR 11
PY 2017
VL 17
AR 310
DI 10.1186/s12889-017-4219-6
PG 9
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA EU1RP
UT WOS:000400798000003
PM 28399838
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Zhang, ZB
   Zhu, LW
   Wang, ZQ
   Hua, N
   Hu, SY
   Chen, YD
AF Zhang, Zhengbin
   Zhu, Liwen
   Wang, Ziqian
   Hua, Ning
   Hu, Shunying
   Chen, Yundai
TI Can the new adipokine asprosin be a metabolic troublemaker for
   cardiovascular diseases? A state-of-the-art review
SO PROGRESS IN LIPID RESEARCH
LA English
DT Review
DE Asprosin; Metabolic disorder; Cardiovascular disease; Atherosclerosis
ID SYMPATHETIC-NERVOUS-SYSTEM; POLYCYSTIC-OVARY-SYNDROME; SERUM ASPROSIN;
   DIABETES-MELLITUS; OXIDATIVE STRESS; PLASMA ASPROSIN; PROTEIN;
   INFLAMMATION; ASSOCIATION; CACHEXIA
AB Adipokines play a significant role in cardiometabolic diseases. Asprosin, a newly discovered adipokine, was first identified as a glucose-raising protein hormone. Asprosin also stimulates appetite and regulates glucose and lipid metabolism. Its identified receptors so far include Olfr734 and Ptprd. Clinical studies have found that asprosin may be associated with cardiometabolic diseases. Asprosin may have diagnostic and therapeutic potential in obesity, diabetes, metabolic syndrome and atherosclerotic cardiovascular diseases. Herein, the structure, re-ceptors, and functions of asprosin and its relationship with cardiometabolic diseases are summarized based on recent findings.
C1 [Zhang, Zhengbin; Wang, Ziqian; Hua, Ning; Hu, Shunying; Chen, Yundai] Chinese Peoples Liberat Army Gen Hosp, Med Ctr 6, Sr Dept Cardiol, 6 Fucheng Rd, Beijing 100048, Peoples R China.
   [Zhang, Zhengbin; Hua, Ning] Chinese Peoples Liberat Army Gen Hosp, Med Ctr 8, Dept Cardiol, 17 Heishanhu Rd, Beijing 100091, Peoples R China.
   [Zhang, Zhengbin; Wang, Ziqian] Chinese PLA Med Sch, 28 Fuxing Rd, Beijing 100853, Peoples R China.
   [Zhu, Liwen] Chinese Peoples Liberat Army Gen Hosp, Med Ctr 4, Dept Cardiol, 51 Fucheng Rd, Beijing 100048, Peoples R China.
C3 Chinese People's Liberation Army General Hospital; Chinese People's
   Liberation Army General Hospital; Chinese People's Liberation Army
   General Hospital
RP Hu, SY; Chen, YD (corresponding author), Chinese Peoples Liberat Army Gen Hosp, Med Ctr 6, Sr Dept Cardiol, 6 Fucheng Rd, Beijing 100048, Peoples R China.
EM hsylily@163.com; cyundai@vip.163.com
RI Ning, HU/AAG-2475-2021
FU National Natural Science Foundation of China [81827808]; Chinese PLA
   General Hospital Youth Independent Innovation Science Fund [22QNFC103]
FX Funding This work was supported by National Natural Science Foundation
   of China (81827808) , Chinese PLA General Hospital Youth Independent
   Innovation Science Fund (22QNFC103) .
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NR 133
TC 4
Z9 4
U1 3
U2 25
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0163-7827
EI 1873-2194
J9 PROG LIPID RES
JI Prog. Lipid Res.
PD JUL
PY 2023
VL 91
AR 101240
DI 10.1016/j.plipres.2023.101240
EA JUL 2023
PG 16
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA P0YQ7
UT WOS:001047985600001
PM 37473965
DA 2025-06-11
ER

PT J
AU Ab-Hamid, N
   Omar, N
   Ismail, CAN
   Long, ID
AF Ab-Hamid, Norhamidar
   Omar, Norsuhana
   Ismail, Che Aishah Nazariah
   Long, Idris
TI Diabetes and cognitive decline: Challenges and future direction
SO WORLD JOURNAL OF DIABETES
LA English
DT Review
DE Diabetes mellitus; Insulin signaling; Macrovascular disease;
   Microvascular disease; Animal models; Cognitive decline; Pathophysiology
ID OBESE ZUCKER RATS; OXIDATIVE STRESS; MITOCHONDRIAL DYSFUNCTION;
   INSULIN-RESISTANCE; MEMORY IMPAIRMENT; SEVERE HYPOGLYCEMIA; SPATIAL
   MEMORY; OLDER-ADULTS; RISK-FACTORS; TYPE-2
AB There is growing evidence that diabetes can induce cognitive decline and dementia. It is a slow, progressive cognitive decline that can occur in any age group, but is seen more frequently in older individuals. Symptoms related to cognitive decline are worsened by chronic metabolic syndrome. Animal models are frequently utilized to elucidate the mechanisms of cognitive decline in diabetes and to assess potential drugs for therapy and prevention. This review addresses the common factors and pathophysiology involved in diabetes-related cognitive decline and outlines the various animal models used to study this condition.
C1 [Ab-Hamid, Norhamidar; Long, Idris] Univ Sains Malaysia, Sch Hlth Sci, Biomed Program, Hlth Campus, Kota Baharu 16150, Kelantan, Malaysia.
   [Omar, Norsuhana; Ismail, Che Aishah Nazariah] Univ Sains Malaysia, Sch Med Sci, Dept Physiol, Hlth Campus, Kota Baharu 16150, Kelantan, Malaysia.
   [Long, Idris] Univ Sains Malaysia, Sch Hlth Sci, Biomed Program, Hlth Campus,Jalan Hosp USM, Kota Baharu 16150, Kelantan, Malaysia.
C3 Universiti Sains Malaysia; Universiti Sains Malaysia; Universiti Sains
   Malaysia
RP Long, ID (corresponding author), Univ Sains Malaysia, Sch Hlth Sci, Biomed Program, Hlth Campus,Jalan Hosp USM, Kota Baharu 16150, Kelantan, Malaysia.
EM idriskk@usm.my
RI ISMAIL, CHE/S-4910-2018; Long, Idris/J-1670-2016
FU Fundamental Research Grant Scheme (FRGS) Ministry of Higher Education
   Malaysia [FRGS/1/2020/SKK0/USM/03/5]
FX Supported by the Fundamental Research Grant Scheme (FRGS) Ministry of
   Higher Education Malaysia, No. FRGS/1/2020/SKK0/USM/03/5.
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NR 88
TC 12
Z9 13
U1 1
U2 7
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 7041 Koll Center Parkway, Suite 160, PLEASANTON, CA, UNITED STATES
EI 1948-9358
J9 WORLD J DIABETES
JI World J. Diabetes
PD JUN 15
PY 2023
VL 14
IS 6
BP 795
EP 807
DI 10.4239/wjd.v14.i6.795
PG 13
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA L2HY0
UT WOS:001021531200009
PM 37383592
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Ioannidis, I
AF Ioannidis, Ioannis
TI The road from obesity to type 2 diabetes
SO ANGIOLOGY
LA English
DT Article; Proceedings Paper
CT 23rd International Congress of Cardiology
CY MAY 01-03, 2008
CL Athens, GREECE
SP Hellen Heart Fdn
DE diabetes; obesity; insulin resistance; adipokines
ID INSULIN-RESISTANCE; ADIPOSE-TISSUE; INFLAMMATION; STRESS; ADIPOKINES;
   ADIPOCYTE; LINKS
AB It is well known that the relative risk of developing type 2 diabetes mellitus increases with increasing body mass index. The presence of not only excessive body fat but also the pattern of fat distribution (central obesity) is important for other metabolic abnormalities included in the metabolic syndrome. The possible mechanisms linking obesity to type 2 diabetes including high concentrations of free fatty acids, altered adipokines expression (low adiponectin levels and high expression Of tumor necrosis factor-alpha), and low-grade inflammation are reviewed. Finally, the author refers to the theory that the primary defect is beta-cell failure that leads to diabetes as well as to obesity.
C1 Konstantopoulio Hosp, Diabet & Obes Outpatient Clin, Athens 14233, Greece.
RP Ioannidis, I (corresponding author), Konstantopoulio Hosp, Diabet & Obes Outpatient Clin, Agias Olgas 3-5, Athens 14233, Greece.
EM kefion@otenet.gr
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NR 18
TC 28
Z9 37
U1 0
U2 11
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0003-3197
EI 1940-1574
J9 ANGIOLOGY
JI Angiology
PD AUG-SEP
PY 2008
VL 59
SU S
BP 39S
EP 43S
DI 10.1177/0003319708318583
PG 5
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Cardiovascular System & Cardiology
GA 350OJ
UT WOS:000259361800005
PM 18505743
DA 2025-06-11
ER

PT J
AU Jayedi, A
   Soltani, S
   Abdolshahi, A
   Shab-Bidar, S
AF Jayedi, Ahmad
   Soltani, Sepideh
   Abdolshahi, Anna
   Shab-Bidar, Sakineh
TI Healthy and unhealthy dietary patterns and the risk of chronic disease:
   an umbrella review of meta-analyses of prospective cohort studies
SO BRITISH JOURNAL OF NUTRITION
LA English
DT Review
DE CVD; Cohort studies; Diet; Healthy diet; Meta-analyses; Western diet
ID RANDOMIZED CONTROLLED-TRIALS; TYPE-2 DIABETES-MELLITUS;
   CORONARY-HEART-DISEASE; FOOD EATING PATTERNS; METHODOLOGICAL QUALITY;
   PERSPECTIVE NUTRIGRADE; METABOLIC SYNDROME; MEASUREMENT TOOL; SCORING
   SYSTEM; META-EVIDENCE
AB We aimed to fully review the association of empirical dietary patterns with the risk of non-communicable chronic diseases and to rate the quality of the evidence. Published meta-analyses of observational studies investigating the association of empirically derived dietary patterns with the risk of chronic diseases were identified by searching PubMed and Scopus till September 2019. Two independent reviewers extracted the information and rated the quality of the evidence by NutriGrade score. For each meta-analysis, cross-sectional and case-control studies were excluded and then summary relative risk was recalculated by using a random-effects model. Sixteen meta-analyses of prospective cohort studies, reporting eighteen SRR for healthy dietary patterns and sixteen SRR for unhealthy patterns obtained from 116 primary prospective cohort studies with 48 million participants, were included. There was moderate quality of evidence for the inverse association of healthy dietary patterns with the risk of type 2 diabetes (T2D), fracture and colorectal and breast cancers. There was also low-quality evidence for the inverse relation between healthy dietary patterns and the risk of all-cause and cardiovascular mortality, depression, CHD and respiratory diseases. There was moderate quality of evidence for a positive association between unhealthy dietary patterns and the risk of T2D, fracture and the metabolic syndrome. Adopting a healthy dietary pattern may reduce the risk of T2D, CHD and premature death. More research is needed for outcomes for which the quality of the evidence was rated low, such as respiratory disease, mental illness and site-specific cancers.
C1 [Jayedi, Ahmad; Abdolshahi, Anna] Semnan Univ Med Sci, Food Safety Res Ctr Salt, Semnan 35681 33461, Iran.
   [Jayedi, Ahmad; Shab-Bidar, Sakineh] Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Community Nutr, Tehran 14155 6117, Iran.
   [Soltani, Sepideh] Shahid Sadoughi Univ Med Sci, Nutr & Food Secur Res Ctr, Yazd 89169 78477, Iran.
C3 Semnan University of Medical Sciences; Tehran University of Medical
   Sciences; Shahid Sadoughi University of Medical Sciences
RP Shab-Bidar, S (corresponding author), Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Community Nutr, Tehran 14155 6117, Iran.
EM s_shabbidar@tums.ac.ir
RI Shab-Bidar, Sakineh/H-9525-2017; Jayedi, Ahmad/E-7237-2017; Soltani,
   Sepideh/AAH-2679-2020; Abdolshahi, Anna/H-6071-2017
OI Soltani, Sepideh/0000-0002-1591-2569; jayedi, ahmad/0000-0003-4231-3147;
   Abdolshahi, Anna/0000-0001-5414-1253
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NR 77
TC 144
Z9 151
U1 3
U2 51
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1145
EI 1475-2662
J9 BRIT J NUTR
JI Br. J. Nutr.
PD DEC 14
PY 2020
VL 124
IS 11
BP 1133
EP 1144
DI 10.1017/S0007114520002330
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA OO9FG
UT WOS:000587678400002
PM 32600500
DA 2025-06-11
ER

PT J
AU Sequeira, IR
   Woodhead, JST
   Chan, AL
   D'Souza, RF
   Wan, JX
   Hollingsworth, KG
   Plank, LD
   Cohen, P
   Poppitt, SD
   Merry, TL
AF Sequeira, Ivana R.
   Woodhead, Jonathan S. T.
   Chan, Alex
   D'Souza, Randall F.
   Wan, Junxiang
   Hollingsworth, Kieren G.
   Plank, Lindsay D.
   Cohen, Pinchas
   Poppitt, Sally D.
   Merry, Troy L.
TI Plasma mitochondrial derived peptides MOTS-c and SHLP2 positively
   associate with android and liver fat in people without diabetes
SO BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
LA English
DT Article
DE Mitochondria; Obesity; Insulin resistance; DXA; Peptides
ID INSULIN SENSITIVITY; METABOLIC SYNDROME; OBESITY
AB Mitochondrial-derived peptides (MDPs) are encoded by the mitochondrial genome and hypothesised to form part of a retrograde signalling network that modulates adaptive responses to metabolic stress. To understand how metabolic stress regulates MDPs in humans we assessed the association between circulating MOTS-c and SHLP2 and components of metabolic syndrome (MS), as well as depot-specific fat mass in participants without overt type 2 diabetes or cardiovascular disease. One-hundred and twenty-five Chinese participants (91 male, 34 female) had anthropometry, whole body dual-energy X-ray absorptiometry scans and fasted blood samples analysed. Chinese female participants and an additional 34 European Caucasian female participants also underwent magnetic resonance imaging and spectroscopy (MRI/S) for visceral, pancreatic and liver fat quantification. In Chinese participants (age = 41 +/- 1 years, BMI = 27.8 +/- 3.9 kg/m(2)), plasma MOTS-c (315 +/- 27 pg/ml) and SHLP2 (1393 +/- 82 pg/ml) were elevated in those with MS (n = 26). While multiple components of the MS sequelae positively associated with both MOTS-c and SHLP2, including blood pressure, fasting plasma glucose and triglycerides, the most significant of these was waist circumference (p < 0.0001). Android fat had a greater effect on increasing plasma MOTS-c < 0.004) and SHLP2 < 0.009) relative to whole body fat. Associations with MRI/S parameters corrected for total body fat mass revealed that liver fat positively associated with plasma MOTS-c and SHLP2 and visceral fat with SHLP2. Consistent with hepatic stress being a driver of circulating MDP concentrations, plasma MOTS-c and SHLP2 were higher in participants with elevated liver damage markers and in male C57B1/6j mice fed a diet that induces hepatic lipid accumulation and damage. Our findings provide evidence that in the absence of overt type 2 diabetes, components of the MS positively associated with levels of MOTS-c and SHLP2 and that android fat, in particular liver fat, is a primary driver of these associations. MOTS-c and SHLP2 have previously been shown to have cyto- and metabolo-protective properties, therefore we suggest that liver stress may be a mitochondrial peptide signal, and that mitochondrial peptides are part of a hepatic centric-hormetic response intended to restore metabolic balance.
C1 [Sequeira, Ivana R.; Poppitt, Sally D.] Univ Auckland, Sch Biol Sci, Human Nutr Unit, Auckland, New Zealand.
   [Sequeira, Ivana R.; Poppitt, Sally D.] High Value Nutr Natl Sci Challenge, Auckland, New Zealand.
   [Woodhead, Jonathan S. T.; Chan, Alex; D'Souza, Randall F.; Merry, Troy L.] Univ Auckland, Sch Med Sci, Discipline Nutr, Auckland, New Zealand.
   [Woodhead, Jonathan S. T.; Chan, Alex; D'Souza, Randall F.; Merry, Troy L.] Univ Auckland, Maurice Wilkins Ctr Mol Biodiscovery, Auckland, New Zealand.
   [Wan, Junxiang; Cohen, Pinchas] Univ Southern Calif, Leonard Davis Sch Gerontol, Los Angeles, CA 90007 USA.
   [Hollingsworth, Kieren G.] Newcastle Univ, Fac Med Sci, Translat & Clin Res Inst, Newcastle Upon Tyne, Tyne & Wear, England.
   [Plank, Lindsay D.] Univ Auckland, Dept Surg, Auckland, New Zealand.
   [Poppitt, Sally D.] Massey Univ, Riddet CoRE Food & Nutr, Palmerston North, New Zealand.
C3 University of Auckland; University of Auckland; University of Auckland;
   University of Southern California; Newcastle University - UK; University
   of Auckland; Massey University
RP Merry, TL (corresponding author), Univ Auckland, Sch Med Sci, Dept Nutr, Private Bag 92019, Auckland, New Zealand.
EM t.merry@auckland.ac.nz
RI D'Souza, Randall/V-3921-2019
OI Poppitt, Sally/0000-0002-2214-8378
FU Marsden Fast-start grant; New Zealand National Science Challenge High
   Value Nutrition Programme, Ministry for Business, Innovation and
   Employment (MBIE) [3710040]; University of Auckland - Strategic Research
   Initiative - The Food and Health Programme [3718021]; NIH [R01AG069698,
   RF1AG061834, R01AG068405, P30AG068345, P01AG055369]; Rutherford
   Discovery Fellowship; New Zealand National Science Challenge High Value
   Nutrition Programme
FX We would like to thank all our participant for donating their time and
   blood samples. This study was supported by a Marsden Fast-start grant
   (to TLM), the New Zealand National Science Challenge High Value
   Nutrition Programme, Ministry for Business, Innovation and Employment
   (MBIE, grant no. 3710040 to SDP) and The University of Auckland -
   Strategic Research Initiative -The Food and Health Programme Seed
   funding 3718021 (to IRS), and NIH grants R01AG069698, RF1AG061834,
   R01AG068405, P30AG068345, P01AG055369 (to PC). TLM is supported by a
   Rutherford Discovery Fellowship and IRS by the New Zealand National
   Science Challenge High Value Nutrition Programme.
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NR 38
TC 14
Z9 14
U1 0
U2 1
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0304-4165
EI 1872-8006
J9 BBA-GEN SUBJECTS
JI Biochim. Biophys. Acta-Gen. Subj.
PD NOV
PY 2021
VL 1865
IS 11
AR 129991
DI 10.1016/j.bbagen.2021.129991
EA AUG 2021
PG 7
WC Biochemistry & Molecular Biology; Biophysics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics
GA UO8XB
UT WOS:000694973000012
PM 34419510
OA Green Published
DA 2025-06-11
ER

PT J
AU Kadioglu, P
   Yetkin, DO
   Sanli, O
   Yalin, AS
   Onem, K
   Kadioglu, A
AF Kadioglu, Pinar
   Yetkin, Demet Ozgil
   Sanli, Oner
   Yalin, Ayse Serap
   Onem, Kadir
   Kadioglu, Ates
TI Obesity might not be a risk factor for female sexual dysfunction
SO BJU INTERNATIONAL
LA English
DT Article
DE obesity; sexual dysfunction; hormones; depression
ID TURKISH WOMEN; ERECTILE DYSFUNCTION; METABOLIC SYNDROME; INDEX FSFI;
   PREVALENCE; DEPRESSION; HEALTH; POPULATION; LIFE
AB OBJECTIVE
   To evaluate female sexual dysfunction (FSD) in obese women in comparison with age-matched control group, emphasising their hormonal and psychological status.
   PATIENTS, SUBJECTS AND METHODS
   Sixty-four sexually active obese premenauposal women were compared with a control group of 27 age-matched healthy volunteers with a normal body mass index (BMI). The obese group was evaluated in three categories according to BMI (kg/m2), as group 1 (30-34.9), group 2 (35-39.9) and group 3 (> 40). All women were evaluated with Female Sexual Function Index (FSFI) questionnaire and Beck Depression Inventory (BDI). In addition, serum levels of follicle-stimulating hormone, luteinizing hormone, prolactin, dehydroepiandrosterone-SO(4), free testosterone, 17 alpha-hydroxyprogestrone, androstenedione, oestradiol, free thyroxine and thyrotropin were determined.
   RESULTS
   The mean FSFI scores were not statistically significant between control and obese patients (P = 0.29). FSD was diagnosed in 50% (32/64) and 41% (11/27) of the patients in the obese and control groups, respectively (P = 0.34). There were no differences between total FSFI and FSFI domain scores among BMI categories. BDI scores were significantly higher in the obese groups than in healthy controls, and negatively correlated with total FSFI and all FSFI domain scores. Among hormonal analyses, only free testosterone levels were negatively correlated with total FSFI scores.
   CONCLUSION
   This study showed that obesity has no significant relationship with FSD, but obese patients were found to be in a more depressive mood than age-matched normal counterparts.
C1 [Sanli, Oner; Onem, Kadir; Kadioglu, Ates] Istanbul Univ, Istanbul Fac Med, Sect Androl, Dept Urol, TR-34390 Istanbul, Turkey.
   [Kadioglu, Pinar; Yetkin, Demet Ozgil; Yalin, Ayse Serap] Istanbul Univ, Cerrahpasa Fac Med, Dept Endocrinol & Metab, TR-34390 Istanbul, Turkey.
C3 Istanbul University; Istanbul University - Cerrahpasa; Istanbul
   University
RP Kadioglu, A (corresponding author), Istanbul Univ, Istanbul Fac Med, Sect Androl, Dept Urol, TR-34390 Istanbul, Turkey.
EM itfabd@istanbul.edu.tr
RI Kadioglu, Pinar/AAM-9935-2020; Sanli, Oner/ISV-0001-2023; Onem,
   Kadir/IYS-1271-2023; Kadioglu, Ates/AAV-6720-2020
OI Sanli, Oner/0000-0001-5801-6898; Kadioglu, Pinar/0000-0002-8329-140X
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NR 31
TC 70
Z9 76
U1 0
U2 3
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1464-4096
J9 BJU INT
JI BJU Int.
PD NOV
PY 2010
VL 106
IS 9
BP 1357
EP 1361
DI 10.1111/j.1464-410X.2010.09348.x
PG 5
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 665XL
UT WOS:000283070700022
PM 20394615
DA 2025-06-11
ER

PT J
AU Xu, YJ
   Li, X
   Wang, H
AF Xu, Yajie
   Li, Xue
   Wang, Hui
TI Protective Roles of Apigenin Against Cardiometabolic Diseases: A
   Systematic Review
SO FRONTIERS IN NUTRITION
LA English
DT Review
DE apigenin; flavonoid; cardiometabolic disease; metabolic syndrome;
   signaling pathways
ID HEPATIC INSULIN-RESISTANCE; OXIDATIVE STRESS; DIETARY FLAVONOIDS;
   GLUCOSE-UPTAKE; PHENOLIC-COMPOUNDS; ENDOTHELIAL-CELLS;
   ALPHA-GLUCOSIDASE; PHYSICAL-ACTIVITY; LIPID-METABOLISM; UP-REGULATION
AB Apigenin is a flavonoid with antioxidant, anti-inflammatory, and anti-apoptotic activity. In this study, the potential effects of apigenin on cardiometabolic diseases were investigated in vivo and in vitro. Potential signaling networks in different cell types induced by apigenin were identified, suggesting that the molecular mechanisms of apigenin in cardiometabolic diseases vary with cell types. Additionally, the mechanisms of apigenin-induced biological response in different cardiometabolic diseases were analyzed, including obesity, diabetes, hypertension and cardiovascular diseases. This review provides novel insights into the potential role of apigenin in cardiometabolic diseases.
EM yolandadalee@outlook.com; huiwang@shsmu.edu.cn
RI Xu, Yajie/AHE-4135-2022
FU National Nature Science Foundation [81803215, 81630086]; three-year
   Action Program of Shanghai Municipality for Strengthening the
   Construction of Public Health System [GWV-10.2-YQ34]; National Key R&D
   Program of China [2018YFC2000700]; Chinese Academy of Sciences;
   innovative research team of high-level local Universities in Shanghai;
   Medicine and Engineering Interdisciplinary Research Fund of Shanghai
   Jiao Tong University [ZDRW-ZS-2017-1];  [YG2020YQ06]
FX This study was supported by grants from the National Nature Science
   Foundation (81803215 and 81630086); three-year Action Program of
   Shanghai Municipality for Strengthening the Construction of Public
   Health System (GWV-10.2-YQ34); the National Key R & D Program of China
   (2018YFC2000700); the Key Research Program (ZDRW-ZS-2017-1) of the
   Chinese Academy of Sciences; innovative research team of high-level
   local Universities in Shanghai; Medicine and Engineering
   Interdisciplinary Research Fund of Shanghai Jiao Tong University
   (YG2020YQ06).
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NR 134
TC 42
Z9 42
U1 4
U2 44
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD APR 15
PY 2022
VL 9
AR 875826
DI 10.3389/fnut.2022.875826
PG 16
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 1Z4XX
UT WOS:000808830600001
PM 35495935
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU McKenzie, HC
AF McKenzie, Harold C., III
TI Equine Hyperlipidemias
SO VETERINARY CLINICS OF NORTH AMERICA-EQUINE PRACTICE
LA English
DT Article
DE Triglyceride; Energy; Metabolism; Nutrition; Hyperlipemia; Azotemia
ID INSULIN-RESISTANCE; PARENTERAL-NUTRITION; METABOLIC SYNDROME; SEVERE
   HYPERTRIGLYCERIDEMIA; LIPID CONCENTRATIONS; GLUCOSE-TOLERANCE; MINIATURE
   HORSES; ADIPOSE-TISSUE; PLASMA-LIPIDS; PONY FOAL
AB Hyperlipidemia is the presence of elevated lipid concentrations in the blood and is associated with periods of negative energy balance and physiologic stress. In increased concentrations, circulating lipids typically occur in the triglyceride form, which may interfere with numerous normal physiologic functions, particularly by reducing insulin sensitivity. Although the hyperlipidemia risk is greatest in ponies, miniature horses, and donkeys, all equids are at risk if they are in a situation involving negative energy balance. The sedentary lifestyle of many modern horses and the frequent feeding of high-carbohydrate diets contribute substantially to the risk of excessive fat mobilization and the development of hyperlipidemias.
C1 Virginia Polytech & State Univ, Marion duPont Scott Equine Med Ctr, Virginia Maryland Reg Coll Vet Med, Leesburg, VA 20176 USA.
C3 Virginia Polytechnic Institute & State University
RP McKenzie, HC (corresponding author), Virginia Polytech & State Univ, Marion duPont Scott Equine Med Ctr, Virginia Maryland Reg Coll Vet Med, 17690 Old Waterford Rd, Leesburg, VA 20176 USA.
EM hmckenzi@vt.edu
RI Toribio, Ramiro/H-7838-2013; McKenzie, Harold/K-1771-2016
OI Toribio, Ramiro/0000-0002-9063-540X; McKenzie,
   Harold/0000-0001-8230-2237
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NR 62
TC 29
Z9 33
U1 0
U2 67
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0749-0739
J9 VET CLIN N AM-EQUINE
JI Vet. Clin. N. Am.-Equine Pract.
PD APR
PY 2011
VL 27
IS 1
BP 59
EP +
DI 10.1016/j.cveq.2010.12.008
PG 15
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA 745OJ
UT WOS:000289174500006
PM 21392654
DA 2025-06-11
ER

PT J
AU von Versen-Hoeynck, FM
   Powers, RW
AF von Versen-Hoeynck, Frauke Martha
   Powers, Robert William
TI Maternal-fetal metabolism in normal pregnancy and preeclampsia
SO FRONTIERS IN BIOSCIENCE-LANDMARK
LA English
DT Review
DE pregnancy; preeclampsia; carbohydrate; lipid; amino acid; metabolism;
   transport; placenta; review
ID INTRAUTERINE GROWTH RESTRICTION; AMINO-ACID-TRANSPORT; FREE FATTY-ACIDS;
   BODY PROTEIN-TURNOVER; BASAL PLASMA-MEMBRANE; INSULIN-RESISTANCE
   SYNDROME; PLACENTAL OXIDATIVE STRESS; GESTATIONAL-AGE INFANTS;
   NITRIC-OXIDE SYNTHESIS; END-PRODUCT METHOD
AB Adaptation to pregnancy in humans involves major anatomic, physiologic and metabolic changes in the mother in order to support and provide for the nutritional and metabolic needs of the growing conceptus. Metabolically, pregnancy is marked by several important and dynamic adjustments including increased insulin resistance, hyperlipidemia and changes in protein and amino acid metabolism. In general, these metabolic adaptations serve to increase nutrient availability for the benefit of the growing fetal-placental unit. Interestingly, the pregnancy complication preeclampsia is recognized to evidence biologic exaggerations of these normal metabolic adaptations of pregnancy. Specifically, preeclampsia is associated with increased insulin resistance, hypertriglyceridemia, high circulating free fatty acids, low high-density lipoprotein particles, and high maternal and fetal plasma amino acid concentrations. These metabolic alterations may contribute to the pathophysiology of the syndrome and may also influence fetal growth. The focus of this review will be to summarize the normal metabolic adaptations, transport and utilization of carbohydrates, lipids and amino acids that occur during pregnancy. Furthermore, we will review the differences in carbohydrate, lipid and amino acid metabolism in pregnancies complicated by preeclampsia in comparison to uncomplicated pregnancies.
C1 Univ Pittsburgh, Sch Med, Dept Obstet Gynecol & Reprod Sci, Pittsburgh, PA 15213 USA.
   Univ Pittsburgh, Sch Med, Magee Womens Res Inst, Pittsburgh, PA 15213 USA.
   Univ Aachen, Rhein Westfal TH Aachen, Dept Obstet & Gynecol, D-5100 Aachen, Germany.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE); University
   of Pittsburgh; Pennsylvania Commonwealth System of Higher Education
   (PCSHE); University of Pittsburgh; Magee-Womens Research Institute; RWTH
   Aachen University
RP Powers, RW (corresponding author), Univ Pittsburgh, Sch Med, Dept Obstet Gynecol & Reprod Sci, 204 Craft Ave, Pittsburgh, PA 15213 USA.
EM rsirwp@mwri.magee.edu
RI von Versen-Höynck, Frauke/H-3719-2019; von Versen-Hoynck,
   Frauke/P-7160-2017
OI von Versen-Hoynck, Frauke/0000-0002-1924-5695
FU NICHD NIH HHS [P01-HD30367] Funding Source: Medline
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NR 169
TC 45
Z9 48
U1 0
U2 11
PU FRONTIERS IN BIOSCIENCE INC
PI IRVINE
PA 16471 SCIENTIFIC WAY, IRVINE, CA 92618 USA
SN 1093-9946
EI 1093-4715
J9 FRONT BIOSCI-LANDMRK
JI Front. Biosci.
PD JAN 1
PY 2007
VL 12
BP 2457
EP 2470
DI 10.2741/2247
PG 14
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA 129QS
UT WOS:000243745000204
PM 17127255
OA Bronze
DA 2025-06-11
ER

PT J
AU Rosenberg, D
   Lin, E
   Peterson, D
   Ludman, E
   Von Korff, M
   Katon, W
AF Rosenberg, Dori
   Lin, Elizabeth
   Peterson, Do
   Ludman, Evette
   Von Korff, Michael
   Katon, Wayne
TI Integrated medical care management and behavioral risk factor reduction
   for multicondition patients: behavioral outcomes of the TEAMcare trial
SO GENERAL HOSPITAL PSYCHIATRY
LA English
DT Article
DE Physical activity; Diet; Diabetes; Depression; Cardiovascular disease
ID TELEVISION VIEWING TIME; PHYSICAL-ACTIVITY; SEDENTARY BEHAVIOR;
   METABOLIC SYNDROME; DEPRESSIVE SYMPTOMS; DIABETES-MELLITUS;
   HEART-DISEASE; SITTING TIME; OLDER-ADULTS; WOMEN
AB Purpose: The purpose of the study was to compare behavioral outcomes (physical activity, sedentary behavior, smoking cessation, diet) between the intervention and usual care conditions from the TEAMcare trial.
   Methods: TEAMcare was a randomized trial among 214 adults with depression and poorly controlled diabetes and/or coronary heart disease that promoted health behavior change and pharmacotherapy to improve health. Behavioral outcomes were measured with the International Physical Activity Questionnaire (physical activity, sitting time) and the Summary of Diabetes Self-Care Activities Measure (smoking, diet, exercise). Poisson regression models among completers (N=185) were conducted adjusting for age, education, smoking status and depression.
   Results: Intervention participants had more days/week following a healthy eating plan [relative rate=1.2, 95% confidence interval (CI)=1.1-1.4] and more days of participation in 30 min of physical activity (relative rate=1.2, 95% CI=1.1-2.0) compared to usual care. Intervention participants were more likely to meet physical activity guidelines (7.5% increase) compared to usual care (12% decrease; P=.053).
   Conclusion: Diet and activity generally improved for those receiving the intervention, while there were no differences in some aspects of diet (fruit and vegetable and high-fat food intake), smoking status and sitting time between conditions in the TEAMcare trial. (C) 2014 Elsevier Inc. All rights reserved.
C1 [Rosenberg, Dori; Lin, Elizabeth; Peterson, Do; Ludman, Evette; Von Korff, Michael] Grp Hlth Res Inst, Seattle, WA 98101 USA.
   [Katon, Wayne] Univ Washington, Grp Hlth Res Inst, Sch Med, Seattle, WA 98195 USA.
C3 University of Washington; University of Washington Seattle
RP Rosenberg, D (corresponding author), Grp Hlth Res Inst, 1730 Minor Ave Suite 1600, Seattle, WA 98101 USA.
EM rosenberg.d@ghc.org
OI VonKorff, Michael/0000-0001-5386-8477
FU NIMH NIH HHS [R01 MH041739] Funding Source: Medline
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NR 37
TC 20
Z9 23
U1 1
U2 20
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0163-8343
EI 1873-7714
J9 GEN HOSP PSYCHIAT
JI Gen. Hosp. Psych.
PD MAR-APR
PY 2014
VL 36
IS 2
BP 129
EP 134
DI 10.1016/j.genhosppsych.2013.10.017
PG 6
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA AC4XZ
UT WOS:000332525900001
PM 24333157
OA hybrid, Green Accepted
DA 2025-06-11
ER

PT J
AU Katzmarzyk, PT
   Denstel, KD
   Martin, CK
   Newton, RL
   Apolzan, JW
   Mire, EF
   Horswell, R
   Johnson, WD
   Brown, AW
   Zhang, DC
AF Katzmarzyk, Peter T.
   Denstel, Kara D.
   Martin, Corby K.
   Newton, Robert L.
   Apolzan, John W.
   Mire, Emily F.
   Horswell, Ronald
   Johnson, William D.
   Brown, Andrew W.
   Zhang, Dachuan
CA PROPEL Res Grp
TI Intraclass correlation coefficients for weight loss cluster randomized
   trials in primary care: The PROPEL trial
SO CLINICAL OBESITY
LA English
DT Article
DE design effect; group-randomized; obesity; power; sample size
ID SAMPLE-SIZE; DESIGN; MANAGEMENT; IMPACT
AB The aim of this study was to compute intra-class correlations (ICCs) for weight-related and patient-reported outcomes in a cluster randomized clinical trial (cRCT) for weight loss. Baseline and follow-up data from the Promoting Successful Weight Loss in Primary Care in Louisiana (PROPEL) cRCT were used in this analysis. ICCs were computed for baseline and follow-up measures, and changes in body weight, cardiometabolic risk factors and health-related and weight-related quality of life at 6, 12, 18 and 24 months. Baseline ICCs ranged from 0 for PROMIS measures of anxiety and fatigue to 0.055 for total cholesterol (median - 0.019). The ICCs were higher for changes and decreased over time during follow-up. The ICCs for changes were highest in the pooled sample (intervention and usual care combined) followed by the intervention and usual care groups, respectively. The results demonstrated significant ICCs for several outcomes in a weight loss cRCT. The ICCs differed in magnitude depending on whether baseline versus longitudinal data were used, whether data were combined across treatment arms or were considered separately, and varied across the follow-up period. All these factors must be considered when choosing an ICC to inform sample size estimates for future weight loss cRCTs conducted in primary care settings.
C1 [Katzmarzyk, Peter T.; Denstel, Kara D.; Martin, Corby K.; Newton, Robert L.; Apolzan, John W.; Mire, Emily F.; Horswell, Ronald; Johnson, William D.; Zhang, Dachuan] Pennington Biomed Res Ctr, 6400 Perkins Rd, Baton Rouge, LA 70808 USA.
   [Brown, Andrew W.] Indiana Univ, Sch Publ Hlth Bloomington, Dept Appl Hlth Sci, Bloomington, IN USA.
C3 Louisiana State University System; Louisiana State University;
   Pennington Biomedical Research Center; Indiana University System;
   Indiana University Bloomington
RP Katzmarzyk, PT (corresponding author), Pennington Biomed Res Ctr, 6400 Perkins Rd, Baton Rouge, LA 70808 USA.
EM peter.katzmarzyk@pbrc.edu
RI Newton, Robert/A-3466-2009; Martin, Corby/N-1976-2017; Brown,
   Andrew/N-1826-2013; Price-Haywood, Eboni/L-5527-2014; Apolzan,
   John/N-1949-2017; Katzmarzyk, Peter/N-1974-2017
OI Newton, Robert/0000-0002-6863-913X; Brown, Andrew/0000-0002-1758-8205;
   Price-Haywood, Eboni/0000-0003-2901-3852; Apolzan,
   John/0000-0001-8492-7820; Katzmarzyk, Peter/0000-0002-9280-6022
FU National Institutes of Health [P30DK072476, R25DK099080, R25HL124208,
   U54 GM104940]; PatientCentered Outcomes Research Institute
   [OB-1402-10977]
FX National Institutes of Health, Grant/Award Numbers: P30DK072476,
   R25DK099080, R25HL124208, U54 GM104940; PatientCentered Outcomes
   Research Institute, Grant/ Award Number: OB-1402-10977
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NR 26
TC 5
Z9 6
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 1758-8103
EI 1758-8111
J9 CLIN OBES
JI Clin. Obes.
PD AUG
PY 2022
VL 12
IS 4
AR e12524
DI 10.1111/cob.12524
EA APR 2022
PG 9
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA 2W6SC
UT WOS:000780948400001
PM 35412010
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Ming, LJ
   Yin, ACY
AF Ming, Lee Jia
   Yin, Adeline Chia Yoke
TI Therapeutic Effects of Glycyrrhizic Acid
SO NATURAL PRODUCT COMMUNICATIONS
LA English
DT Article
DE Glycyrrhizic acid; Anti-diabetic; Anti-viral; Anti-tumor;
   Anti-inflammatory; Antimicrobial; Antioxidant
ID N-ACETYLTRANSFERASE ACTIVITY; ANTIVIRAL ACTIVITY; LICORICE; INHIBITION;
   CARCINOGENESIS; HYPOKALEMIA; CONSUMPTION; DERIVATIVES; RESPONSES
AB Glycyrrhizic acid (GA), belonging to a class of triterpenes, is a conjugate of two molecules, namely glucuronic acid and glycyrrhetinic acid. It is naturally extracted from the roots of licorice plants. With its more common uses in the confectionery and cosmetics industry, GA extends its applications as a herbal medicine for a wide range of ailments. At low appropriate doses, anti-inflammatory, anti-diabetic, antioxidant, anti-tumor, antimicrobial and anti-viral properties have been reported by researchers worldwide. This review summarizes the effects of GA on metabolic syndrome, tumorigenesis, microbes and viruses, oxidative stress, and inflammation, as well as the reported side effects of the drug.
C1 [Ming, Lee Jia; Yin, Adeline Chia Yoke] Taylors Univ, Sch Biosci, Selangor, Malaysia.
C3 Taylor's University
RP Ming, LJ (corresponding author), Taylors Univ, Sch Biosci, Lakeside Campus, Selangor, Malaysia.
EM jm5223lee@gmail.com
RI Chia, Adeline/I-7424-2013
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NR 39
TC 162
Z9 184
U1 3
U2 63
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1934-578X
EI 1555-9475
J9 NAT PROD COMMUN
JI Nat. Prod. Commun.
PY 2013
VL 8
IS 3
BP 415
EP 418
PG 4
WC Chemistry, Medicinal; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Food Science & Technology
GA 114YI
UT WOS:000316778500035
PM 23678825
DA 2025-06-11
ER

PT J
AU Mattson, MP
AF Mattson, MP
TI Energy intake, meal frequency, and health: A neurobiological perspective
SO ANNUAL REVIEW OF NUTRITION
SE Annual Review of Nutrition
LA English
DT Review; Book Chapter
DE BDNF; caloric restriction; insulin resistance; obesity; serotonin
ID INSULIN-RESISTANCE SYNDROME; CENTRAL-NERVOUS-SYSTEM; CALORIC
   RESTRICTION; DIETARY RESTRICTION; NEUROTROPHIC-FACTOR; LIFE-SPAN;
   GLUCOSE-METABOLISM; MITOCHONDRIAL-FUNCTION; FOOD RESTRICTION;
   BODY-COMPOSITION
AB The size and frequency of meals are fundamental aspects of nutrition that can have profound effects on the health and longevity of laboratory animals. In humans, excessive energy intake is associated with increased incidence of cardiovascular disease, diabetes, and certain cancers and is a major cause of disability and death in industrialized countries. On the other hand, the influence of meal frequency on human health and longevity is unclear. Both caloric (energy) restriction (CR) and reduced meal frequency/intermittent fasting can suppress the development of various diseases and can increase life span in rodents by mechanisms involving reduced oxidative damage and increased stress resistance. Many of the beneficial effects of CR and fasting appear to be mediated by the nervous system. For example, intermittent fasting results in increased production of brain-derived neurotrophic factor (BDNF), which increases the resistance of neurons in the brain to dysfunction and degeneration in animal models of neurodegenerative disorders; BDNF signaling may also mediate beneficial effects of intermittent fasting on glucose regulation and cardiovascular function. A better understanding of the neurobiological mechanisms by which meal size and frequency affect human health may lead to novel approaches for disease prevention and treatment.
C1 NIA, Intramural Res Program, Neurosci Lab, Baltimore, MD 21224 USA.
   Johns Hopkins Univ, Sch Med, Dept Neurosci, Baltimore, MD 21205 USA.
C3 National Institutes of Health (NIH) - USA; NIH National Institute on
   Aging (NIA); Johns Hopkins University
RP NIA, Intramural Res Program, Neurosci Lab, Baltimore, MD 21224 USA.
EM mattsonm@grc.nia.nih.gov
RI Mattson, Mark/F-6038-2012
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NR 144
TC 197
Z9 232
U1 0
U2 71
PU ANNUAL REVIEWS
PI PALO ALTO
PA 4139 EL CAMINO WAY, PO BOX 10139, PALO ALTO, CA 94303-0139 USA
SN 0199-9885
EI 1545-4312
J9 ANNU REV NUTR
JI Annu. Rev. Nutr.
PY 2005
VL 25
BP 237
EP 260
DI 10.1146/annurev.nutr.25.050304.092526
PG 24
WC Nutrition & Dietetics
WE Book Citation Index – Science (BKCI-S); Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nutrition & Dietetics
GA 962DD
UT WOS:000231710300013
PM 16011467
DA 2025-06-11
ER

PT J
AU Spinelli, A
   Lanza, GA
   Calcagni, ML
   Sestito, A
   Sgueglia, GA
   Di Monaco, A
   Bruno, I
   Lamendola, P
   Barone, L
   Giordano, A
   Crea, F
AF Spinelli, Antonella
   Lanza, Gaetano A.
   Calcagni, Maria Lucia
   Sestito, Alfonso
   Sgueglia, Gregory A.
   Di Monaco, Antonio
   Bruno, Isabella
   Lamendola, Priscilla
   Barone, Lucy
   Giordano, Alessandro
   Crea, Filippo
TI Effect of spinal cord stimulation on cardiac adrenergic nerve function
   in patients with cardiac syndrome X
SO JOURNAL OF NUCLEAR CARDIOLOGY
LA English
DT Article
DE Syndrome X; metaiodobenzylguanidine cardiac scintigraphy; spinal cord
   stimulation
ID NORMAL CORONARY-ARTERIES; TERM-FOLLOW-UP; ANGINA-PECTORIS; CHEST-PAIN;
   MYOCARDIAL-PERFUSION; SENSITIVITY; MECHANISMS; FUTURE; STRESS
AB Background. In patients with cardiac syndrome X (CSX) who present with refractory angina episodes, spinal cord stimulation (SCS) has beneficial effects. The mechanisms of SCS, however, remain speculative. We assessed the effects of SCS on cardiac sympathetic function in these patients.
   Methods and Results. We studied 11 CSX patients treated by SCS for refractory angina (mean age, 60 9 years; 5 men and 6 women), both during SCS therapy (SCS-ON) and after withdrawal of SCS therapy (SCS-OFF), using a randomized crossover design. Planar and single photon emission computed tomography iodine 123 metaiodobenzylguanidine (MIBG) myocardial scintigraphy and technetium 99m sestamibi (MIBI) bicycle exercise stress testing were performed at the end of each period. Compared with 10 healthy control subjects, CSX patients showed a lower heart-mediastinum ratio for MIBG uptake (2.19 +/- 0.3 vs 1.69 +/- 0.3, P =.001) and a higher cardiac MIBG uptake score (4.0 +/- 2.5 vs 19.7 +/- 27, P =.08). There were no differences in CSX patients during the SCS-ON and SCS-OFF phases of the study in heart-mediastinum ratio (1.74 +/- 0.3 vs 1.69 +/- 0.3, P =.13), cardiac washout rate of MIBG (42.9% +/- 14% vs 43.3% +/- 14%, P =.08), or MIBG defect score (18.7 +/- 25 vs 19.7 +/- 27, P =.22). Reversible perfusion defects during the SCS-OFF phase were detected in 8 patients; an improvement in perfusion defects was observed in 2 patients (25%) during the SCS-ON phase.
   Conclusions. Our data confirm the presence of abnormal cardiac adrenergic nerve function in CSX patients. SCS was unable to result in significant improvement of cardiac MIBG uptake abnormalities, suggesting that its therapeutic effects are unlikely to be mediated by modulation of cardiac adrenergic nerve activity. (J Nucl Cardiol 2008;15:804-10.)
C1 [Spinelli, Antonella; Lanza, Gaetano A.; Sestito, Alfonso; Sgueglia, Gregory A.; Di Monaco, Antonio; Lamendola, Priscilla; Barone, Lucy; Crea, Filippo] Univ Cattolica Sacro Cuore, Ist Cardiol, I-00168 Rome, Italy.
   [Calcagni, Maria Lucia; Bruno, Isabella; Giordano, Alessandro] Univ Cattolica Sacro Cuore, Inst Nucl Med, I-00168 Rome, Italy.
C3 Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli;
   Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli
RP Lanza, GA (corresponding author), Univ Cattolica Sacro Cuore, Ist Cardiol, Largo A Gemelli 8, I-00168 Rome, Italy.
EM g.a.lanza@inwind.it
RI Calcagni, Maria Lucia/AAC-7214-2022; Crea, Filippo/AAC-9754-2022;
   BArone, Lucy/JFS-7992-2023; Giordano, Alessandro/AAW-9921-2021; Lanza,
   Gaetano/AAC-2660-2019; Di monaco, Antonio/AAR-8825-2021; Sgueglia,
   Gregory/A-9701-2019
OI Giordano, Alessandro/0000-0002-6978-0880; Di monaco,
   Antonio/0000-0002-1297-2056; Barone, Lucy/0000-0001-9476-9168; Sgueglia,
   Gregory/0000-0001-9680-7412
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NR 24
TC 9
Z9 10
U1 0
U2 3
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1071-3581
J9 J NUCL CARDIOL
JI J. Nucl. Cardiol.
PD NOV-DEC
PY 2008
VL 15
IS 6
BP 804
EP 810
DI 10.1016/j.nuclcard.2008.06.008
PG 7
WC Cardiac & Cardiovascular Systems; Radiology, Nuclear Medicine & Medical
   Imaging
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Radiology, Nuclear Medicine &
   Medical Imaging
GA 368TG
UT WOS:000260644800011
PM 18984456
DA 2025-06-11
ER

PT J
AU Baenas, I
   Camacho-Barcia, L
   Granero, R
   Razquin, C
   Corella, D
   Gomez-Martinez, C
   Castaner-Nino, O
   Martinez, JA
   Alonso-Gomez, AM
   Waernberg, J
   Vioque, J
   Romaguera, D
   Lopez-Miranda, J
   Estruch, R
   Tinahones, FJ
   Lapetra, J
   Serra-Majem, JL
   Cano-Ibanez, N
   Tur, JA
   Martin-Sanchez, V
   Pinto, X
   Gaforio, JJ
   Matia-Martin, P
   Vidal, J
   Vazquez, C
   Daimiel, L
   Ros, E
   Jimenez-Murcia, S
   Dalsgaard, S
   Garcia-Arellano, A
   Babio, N
   Sorli, JV
   Lassale, C
   Garcia-de-la-Hera, M
   Gomez-Garcia, E
   Zulet, MA
   Konieczna, J
   Martin-Pelaez, S
   Tojal-Sierra, L
   Basterra-Gortari, FJ
   de las Heras-delgado, S
   Portoles, O
   Munoz-Perez, MA
   Arenas-Larriva, AP
   Compan-Gabucio, L
   Eguaras, S
   Shyam, S
   Fito, M
   Banos, RM
   Salas-Salvado, J
   Fernandez-Aranda, F
AF Baenas, I.
   Camacho-Barcia, L.
   Granero, R.
   Razquin, C.
   Corella, D.
   Gomez-Martinez, C.
   Castaner-Nino, O.
   Martinez, J. A.
   Alonso-Gomez, a. M.
   Waernberg, J.
   Vioque, J.
   Romaguera, D.
   Lopez-Miranda, J.
   Estruch, R.
   Tinahones, F. J.
   Lapetra, J.
   Serra-Majem, J. L.
   Cano-Ibanez, N.
   Tur, J. A.
   Martin-Sanchez, V.
   Pinto, X.
   Gaforio, J. J.
   Matia-Martin, P.
   Vidal, J.
   Vazquez, C.
   Daimiel, L.
   Ros, E.
   Jimenez-Murcia, S.
   Dalsgaard, S.
   Garcia-Arellano, A.
   Babio, N.
   Sorli, J. V.
   Lassale, C.
   Garcia-de-la-Hera, M.
   Gomez-Garcia, E.
   Zulet, M. A.
   Konieczna, J.
   Martin-Pelaez, S.
   Tojal-Sierra, L.
   Basterra-Gortari, F. J.
   de las Heras-delgado, S.
   Portoles, O.
   Munoz-Perez, M. a.
   Arenas-Larriva, A. P.
   Compan-Gabucio, L.
   Eguaras, S.
   Shyam, S.
   Fito, M.
   Banos, R. M.
   Salas-Salvado, J.
   Fernandez-Aranda, F.
TI Association between type 2 diabetes and depressive symptoms after a
   1-year follow-up in an older adult Mediterranean population
SO JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
LA English
DT Article
DE Type 2 diabetes; Depressive symptoms; Metabolic syndrome; HbA1c;
   Severity
ID PHYSICAL-ACTIVITY; DISTRESS; PREVENTION; MECHANISMS; ADHERENCE; PEOPLE;
   MOOD; DIET
AB Objectives To examine the cross-sectional association between baseline depressive symptoms and the presence of type 2 diabetes (T2D), and its association with glycated hemoglobin (HbA1c) and other metabolic variables, and the prospective association of depressive symptoms and HbA1c after 1 year of follow-up.Methods n = 6224 Mediterranean older adults with overweight/obesity and metabolic syndrome (48% females, mean age 64.9 +/- 4.9 years) were evaluated in the framework of the PREDIMED-Plus study cohort. Depressive symptoms were assessed using the Beck Depression Inventory-II and HbA1c was used to measure metabolic control.Results The presence of T2D increased the likelihood of higher levels of depressive symptoms (chi(2)= 15.84, p = 0.001). Polynomial contrast revealed a positive linear relationship (chi(2)= 13.49, p = 0.001), the higher the depressive symptoms levels, the higher the prevalence of T2D. Longitudinal analyses showed that the higher baseline depressive symptoms levels, the higher the likelihood of being within the HbA1c >= 7% at 1-year level (Wald-chi(2) = 24.06, df = 3, p < .001, for the full adjusted model). Additionally, depressive levels at baseline and duration of T2D predicted higher HbA1c and body mass index, and lower physical activity and adherence to Mediterranean Diet at 1 year of follow-up.Conclusions This study supports an association between T2D and the severity of depressive symptoms, suggesting a worse metabolic control from mild severity levels in the short-medium term, influenced by lifestyle habits related to diabetes care. Screening for depressive symptoms and a multidisciplinary integrative therapeutic approach should be ensured in patients with T2D.
C1 [Baenas, I.; Camacho-Barcia, L.; Jimenez-Murcia, S.; Fernandez-Aranda, F.] Univ Hosp Bellvitge, Clin Psychol Unit, IDIBELL, Feixa Llarga S-N, Barcelona 08907, Spain.
   [Baenas, I.; Camacho-Barcia, L.; Granero, R.; Razquin, C.; Corella, D.; Gomez-Martinez, C.; Martinez, J. A.; Alonso-Gomez, a. M.; Waernberg, J.; Romaguera, D.; Lopez-Miranda, J.; Estruch, R.; Tinahones, F. J.; Lapetra, J.; Serra-Majem, J. L.; Tur, J. A.; Pinto, X.; Vazquez, C.; Daimiel, L.; Ros, E.; Jimenez-Murcia, S.; Garcia-Arellano, A.; Babio, N.; Sorli, J. V.; Lassale, C.; Gomez-Garcia, E.; Zulet, M. A.; Konieczna, J.; Tojal-Sierra, L.; Basterra-Gortari, F. J.; de las Heras-delgado, S.; Portoles, O.; Arenas-Larriva, A. P.; Shyam, S.; Fito, M.; Banos, R. M.; Salas-Salvado, J.; Fernandez-Aranda, F.] Inst Salud Carlos III, Ctr Invest Biomed Red Fisiopatol Obes & Nutr CIBE, Madrid 28029, Spain.
   [Baenas, I.; Camacho-Barcia, L.; Granero, R.; Jimenez-Murcia, S.; Fernandez-Aranda, F.] Bellvitge Biomed Res Inst IDIBELL, Neurosci Programme, Psychoneurobiol Eating & Addict Behav Grp, Barcelona, Spain.
   [Baenas, I.] Univ Barcelona, Fac Psicol, E-08007 Barcelona, Spain.
   [Granero, R.] Univ Autonoma Barcelona, Dept Fis, E-08193 Barcelona, Spain.
   [Razquin, C.; Garcia-Arellano, A.; Basterra-Gortari, F. J.; Portoles, O.; Eguaras, S.] Univ Navarra, Dept Prevent Med & Publ Hlth, Pamplona 31008, Spain.
   [Corella, D.; Sorli, J. V.] Univ Valencia, Dept Prevent Med & Publ Hlth, Valencia, Spain.
   [Gomez-Martinez, C.; Babio, N.; de las Heras-delgado, S.; Shyam, S.; Salas-Salvado, J.] Univ Rovira & Virgili, Fac Med & Hlth Sci, Dept Biochem & Biotechnol, Human Nutr Unit, C St Llorenc 21, E-43201 Reus, Spain.
   [Gomez-Martinez, C.; Babio, N.; de las Heras-delgado, S.; Shyam, S.; Salas-Salvado, J.] Inst Invest Sanitaria Pere Virgili IISPV, Reus 43007, Spain.
   [Castaner-Nino, O.; Fito, M.] Inst Municipal Invest Med, Cardiovasc Risk & Nutr Res Unit, E-08003 Barcelona, Spain.
   [Castaner-Nino, O.; Vioque, J.; Cano-Ibanez, N.; Martin-Sanchez, V.; Gaforio, J. J.; Garcia-de-la-Hera, M.; Martin-Pelaez, S.; Compan-Gabucio, L.] Inst Salud Carlos III, CIBER Epidemiol & Salud Publ CIBERESP, Madrid 28029, Spain.
   [Martinez, J. A.; Zulet, M. A.] Univ Navarra, Ctr Nutr Res, Dept Nutr Food Sci & Physiol, Pamplona 31008, Spain.
   [Martinez, J. A.; Zulet, M. A.] CEI UAM CSIC, Precis Nutr & Cardiometab Hlth Program, IMDEA Food Inst, Madrid 28049, Spain.
   [Alonso-Gomez, a. M.; Tojal-Sierra, L.] Univ Basque Country UPV EHU, Vitoria Gasteiz Nursing Sch, Osakidetza Basque Hlth Serv, Vitoria 01009, Spain.
   [Waernberg, J.; Gomez-Garcia, E.] Univ Malaga, Inst Biomed Res Malaga IBIMA Bionand Platform, Malaga 29590, Spain.
   [Vioque, J.; Garcia-de-la-Hera, M.; Compan-Gabucio, L.] Univ Miguel Hernandez ISABIAL UMH, Inst Invest Sanitaria & Biomed Alicante, Alicante 03010, Spain.
   [Romaguera, D.; Konieczna, J.] Hosp Univ Son Espases, Hlth Res Inst Balear Isl IdISBa, Palma De Mallorca 07120, Spain.
   [Lopez-Miranda, J.; Arenas-Larriva, A. P.] Univ Cordoba, Reina Sofia Univ Hosp, Maimonides Biomed Res Inst Cordoba IMIBIC, Dept Internal Med,Lipids & Atherosclerosis Unit, E-14004 Cordoba, Spain.
   [Estruch, R.] Univ Barcelona, Hosp Clin, Dept Internal Med, Inst Invest Biomed August Pi & Sunyer IDIBAPS, E-08036 Barcelona, Spain.
   [Tinahones, F. J.] Univ Malaga, Hosp Univ Virgen Victoria, Inst Invest Biomed Malaga IBIMA, CIBERehd,Serv Farmacol Clin, Malaga, Spain.
   [Lapetra, J.] Serv Andaluz Salud, Dist Sanitario Atenc Primaria Sevilla, Dept Family Med, Seville, Spain.
   [Serra-Majem, J. L.] Univ Las Palmas Gran Canaria, Res Inst Biomed & Hlth Sci IUIBS, Toxicol Unit, Las Palmas Gran Canaria 35016, Spain.
   [Cano-Ibanez, N.; Martin-Pelaez, S.] Univ Granada, Dept Prevent Med & Publ Hlth, E-18071 Granada, Spain.
   [Cano-Ibanez, N.] Inst Invest Biosanit Granada ibsGRANADA, Granada, Spain.
   [Tur, J. A.] Univ Balear Isl, Res Grp Community Nutr & Oxidat Stress, Palma De Mallorca 07122, Spain.
   [Martin-Sanchez, V.] Univ Leon, Inst Biomed IBIOMED, E-24071 Leon, Spain.
   [Pinto, X.] Univ Barcelona, CIBERobn ISCIII, Hosp Univ Bellvitge IDIBELL, Dept Internal Med, E-08007 Barcelona, Spain.
   [Gaforio, J. J.] Univ Jaen, Dept Estadist & Invest Operat, Jaen 23071, Spain.
   [Matia-Martin, P.] Inst Invest Sanitaria Hosp Clin San Carlos IdISSC, Madrid 28040, Spain.
   [Vidal, J.] Inst Salud Carlos III ISCIII, CIBER Diabet & Enfermedades Metab CIBERDEM, Madrid 28029, Spain.
   [Vidal, J.] Univ Barcelona, CIBERES, Inst Invest Biomed August Pi & Sunyer IDIBAPS, Hosp Clin, Barcelona, Spain.
   [Vazquez, C.] Univ Autonoma, Inst Invest Sanitaria Fdn Jimenez Diaz, Hosp Univ Fdn Jimenez Diaz, Madrid, Spain.
   [Daimiel, L.] CEU Univ, Univ San Pablo CEU, Fac Farm, Dept Ciencias Farmaceut & Salud, Madrid, Spain.
   [Ros, E.] Hosp Clin Barcelona, Clin Lipids, Endocrinol & Nutr Dept, Inst Invest Biomed August Pi Sunyer IDIBAPS, Barcelona 08036, Spain.
   [Jimenez-Murcia, S.; Fernandez-Aranda, F.] Univ Barcelona, Sch Med & Hlth Sci, Dept Clin Sci, Barcelona, Spain.
   [Dalsgaard, S.] Aarhus Univ, Natl Ctr Register Based Res NCRR, Aarhus, Denmark.
   [Dalsgaard, S.] IPSYCH The Lundbeck Fdn Initiat Integrat Psychiat, Fuglesangs 26, Aarhus, Denmark.
   [Dalsgaard, S.] Aarhus Univ, Ctr Integrated Register Based Res, CIRRAU, Aarhus, Denmark.
   [Lassale, C.] Barcelona Inst Global Hlth ISGlobal, Barcelona, Spain.
   [Basterra-Gortari, F. J.] Univ Publ Navarra, Hosp Univ Navarra, Navarrabiomed, IdiSNA, Pamplona 31008, Spain.
   [Munoz-Perez, M. a.] Inst Univ Invest Atencio Primaria Jordi Gol IDIAP, Gran Via Corts Catalanes 587, Barcelona 08007, Catalonia, Spain.
   [Banos, R. M.] Univ Valencia, Dept Personal Evaluat & Psychol Treatment, Valencia, Spain.
C3 Institut d'Investigacio Biomedica de Bellvitge (IDIBELL); Bellvitge
   University Hospital; University of Barcelona; Instituto de Salud Carlos
   III; CIBER - Centro de Investigacion Biomedica en Red; CIBEROBN;
   Institut d'Investigacio Biomedica de Bellvitge (IDIBELL); University of
   Barcelona; Autonomous University of Barcelona; University of Navarra;
   University of Valencia; Universitat Rovira i Virgili; Universitat Rovira
   i Virgili; Institut d'Investigacio Sanitaria Pere Virgili (IISPV); CIBER
   - Centro de Investigacion Biomedica en Red; CIBERESP; Instituto de Salud
   Carlos III; University of Navarra; IMDEA Food Institute; Consejo
   Superior de Investigaciones Cientificas (CSIC); University of Basque
   Country; Instituto de Investigacion Biomedica de Malaga y Plataforma en
   Nanomedicina (IBIMA); Universidad de Malaga; General University Hospital
   of Alicante; Universidad Miguel Hernandez de Elche; Universitat
   d'Alacant; Instituto de Investigacion Sanitaria y Biomedica de Alicante
   (ISABIAL); Institut Investigacio Sanitaria Illes Balears (IdISBa);
   Hospital Universitari Son Espases; Universidad de Cordoba; University of
   Barcelona; Hospital Clinic de Barcelona; IDIBAPS; Hospital Virgen de la
   Victoria; Universidad de Malaga; CIBER - Centro de Investigacion
   Biomedica en Red; CIBEREHD; Instituto de Investigacion Biomedica de
   Malaga y Plataforma en Nanomedicina (IBIMA); Universidad de Las Palmas
   de Gran Canaria; University of Granada; Universitat de les Illes
   Balears; Universidad de Leon; Institut d'Investigacio Biomedica de
   Bellvitge (IDIBELL); Bellvitge University Hospital; University of
   Barcelona; CIBER - Centro de Investigacion Biomedica en Red; CIBEROBN;
   Universidad de Jaen; CIBER - Centro de Investigacion Biomedica en Red;
   CIBERDEM; CIBER - Centro de Investigacion Biomedica en Red; CIBERES;
   University of Barcelona; Hospital Clinic de Barcelona; IDIBAPS;
   Autonomous University of Madrid; Fundacion Jimenez Diaz; San Pablo CEU
   University; University of Barcelona; Hospital Clinic de Barcelona;
   IDIBAPS; University of Barcelona; Aarhus University; Lundbeck Foundation
   Initiative for Integrative Psychiatric Research (iPSYCH); Aarhus
   University; ISGlobal; Navarrabiomed; Servicio Navarro de Salud -
   Osasunbidea; Universidad Publica de Navarra; University of Valencia
RP Fernandez-Aranda, F (corresponding author), Univ Hosp Bellvitge, Clin Psychol Unit, IDIBELL, Feixa Llarga S-N, Barcelona 08907, Spain.; Salas-Salvado, J; Fernandez-Aranda, F (corresponding author), Inst Salud Carlos III, Ctr Invest Biomed Red Fisiopatol Obes & Nutr CIBE, Madrid 28029, Spain.; Fernandez-Aranda, F (corresponding author), Bellvitge Biomed Res Inst IDIBELL, Neurosci Programme, Psychoneurobiol Eating & Addict Behav Grp, Barcelona, Spain.; Salas-Salvado, J (corresponding author), Univ Rovira & Virgili, Fac Med & Hlth Sci, Dept Biochem & Biotechnol, Human Nutr Unit, C St Llorenc 21, E-43201 Reus, Spain.; Salas-Salvado, J (corresponding author), Inst Invest Sanitaria Pere Virgili IISPV, Reus 43007, Spain.; Fernandez-Aranda, F (corresponding author), Univ Barcelona, Sch Med & Hlth Sci, Dept Clin Sci, Barcelona, Spain.
EM jordi.salas@urv.cat; ffernandez@bellvitgehospital.cat
RI Garcia de la Hera, Manuela/N-8908-2019; Zulet, M./H-1317-2017; Reparaz,
   Olga/AAB-3243-2019; Tur, Josep/AAE-5748-2020; MARTIN-PELAEZ,
   SANDRA/G-4945-2015; Estruch, Ramon/AAZ-3723-2020; Gómez-Martínez,
   Carlos/AGJ-6387-2022; Lassale, Camille/ABE-7813-2020; Sorlí,
   José/L-8758-2014; Lopez-Miranda, Jose/Y-8306-2019; Muñoz,
   Miguel/X-3511-2019; Martin, Vicente/A-1597-2008; Corella,
   Dolores/L-9888-2014; Warnberg, Julia/G-1390-2011; banos,
   rosa/C-6077-2011; Baenas, Isabel/AAF-6854-2021; Romaguera,
   Dora/ABE-7004-2020; Vioque, Jesus/A-1066-2008; Martínez, J./K-8709-2014;
   Vidal, Josep/MIK-6936-2025; Razquin, Cristina/H-2366-2017; Shyam,
   Sangeetha/G-4636-2013; Castaner, Olga/F-1533-2013; Babio,
   Nancy/AAN-2715-2020; Tinahones, Francisco/AAB-2882-2020; Serra-Majem,
   Lluis/I-6708-2019; ALONSO GOMEZ, ANGEL/HLG-2476-2023; Gabucio,
   Laura/AAN-6068-2020; Daimiel-Ruiz, Lidia/M-7779-2014; Camacho-Barcia,
   Lucia/AAB-2096-2021; FERNANDEZ-ARANDA, FERNANDO/L-9762-2014;
   Salas-Salvado, Jordi/C-7229-2017; Fito Colomer, Montse/C-1822-2012;
   Granero, Roser/F-9492-2016; JIMENEZ-MURCIA, SUSANA/L-9786-2014
OI Tojal Sierra, Lucas/0000-0001-5338-9601; MARTIN PELAEZ,
   SANDRA/0000-0002-2193-3913; Sorli, Jose V/0000-0002-0130-2006;
   Cano-Ibanez, Naomi/0000-0002-3640-5486; Lopez-Miranda,
   Jose/0000-0002-8844-0718; Camacho-Barcia, Lucia/0000-0002-5989-936X;
   Lassale, Camille/0000-0002-9340-2708; FERNANDEZ-ARANDA,
   FERNANDO/0000-0002-2968-9898; Gomez Gracia, Enrique/0000-0002-1281-5798;
   Garcia de la Hera, Manuela/0000-0001-5742-2704; Salas-Salvado,
   Jordi/0000-0003-2700-7459; de las Heras Delgado,
   Sara/0000-0002-3439-5712; Fito Colomer, Montse/0000-0002-1817-483X;
   Granero, Roser/0000-0001-6308-3198; JIMENEZ-MURCIA,
   SUSANA/0000-0002-3596-8033
FU Instituto de Salud Carlos III; Instituto de Salud Carlos III (ISCIII);
   CIBERobn; CIBERdem (all initiatives of ISCIII), Madrid, Spain; ICREA
   under the ICREA-Academia program; Catalan Institution for Research and
   Advanced Studies (ICREA-Academia); CERCA Programme/Generalitat de
   Catalunya; FEDER funds/European Regional Development Fund (ERDF);
   European Social Fund (ESF, investing in your future)
FX The authors would like to thank all the volunteers for the participation
   and personnel for the contribution in the PREDIMED-Plus trial, and all
   the investigators of the PREDIMED-Plus study. The authors would also
   like to thank the PREDIMED-Plus Biobank Network as a part of the
   National Biobank Platform of the ISCIII for storing and managing the
   PREDIMED-Plus biological samples. The authors also thank Instituto de
   Salud Carlos III (ISCIII), CIBERobn, CIBEResp, and CIBERdem (all
   initiatives of ISCIII), Madrid, Spain. JS-S, the senior author of this
   work, gratefully acknowledges the financial support by ICREA under the
   ICREA-Academia program. RG is supported by the Catalan Institution for
   Research and Advanced Studies (ICREA-Academia, 2021-Programme). The
   authors also thank CERCA Programme/Generalitat de Catalunya for
   institutional support, FEDER funds/European Regional Development Fund
   (ERDF), a way to build Europe, and European Social Fund (ESF, investing
   in your future).
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NR 57
TC 4
Z9 4
U1 2
U2 16
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0391-4097
EI 1720-8386
J9 J ENDOCRINOL INVEST
JI J. Endocrinol. Invest.
PD JUN
PY 2024
VL 47
IS 6
BP 1405
EP 1418
DI 10.1007/s40618-023-02278-y
EA JAN 2024
PG 14
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA ST0T8
UT WOS:001142489700002
PM 38218741
OA hybrid
DA 2025-06-11
ER

PT J
AU Tavassol, ZH
   Mousavi, SM
   Molaei, B
   Bandarian, F
   Ejtahed, HS
   Khalagi, K
   Ghannadi, S
   Larijani, B
   Hasani-Ranjbar, S
AF Tavassol, Zahra Hoseini
   Mousavi, Seyed Mohammad
   Molaei, Bahareh
   Bandarian, Fatemeh
   Ejtahed, Hanieh-Sadat
   Khalagi, Kazem
   Ghannadi, Shima
   Larijani, Bagher
   Hasani-Ranjbar, Shirin
TI Association of fat mass and obesity-associated (FTO) gene
   polymorphisms with non-communicable diseases (NCDs) in the Iranian
   population: A systematic review of observational studies
SO JOURNAL OF DIABETES AND METABOLIC DISORDERS
LA English
DT Review
DE Fat mass and obesity-associated gene (FTO); Polymorphism;
   Non-communicable diseases; NCDs; Iran
ID TYPE-2 DIABETES-MELLITUS; POLYCYSTIC-OVARY-SYNDROME; RS9939609
   POLYMORPHISM; ASIAN POPULATIONS; VITAMIN-D; METAANALYSIS; RISK;
   VARIANTS; OVERWEIGHT; INDEX
AB Background Single nucleotide polymorphisms have been implicated in various diseases, most notably non-communicable diseases (NCDs). The aim of this study was to review available evidence regarding associations between FTO polymorphisms and NCDs in the Iranian population. Methods A comprehensive search was conducted through PubMed/Medline and Scopus databases up to December 2021, as well as reference lists of pertinent articles and key journals. All observational studies that examined the association between FTO gene polymorphisms and NCDs in the Iranian population were included. There was no limitation on the publication year. The Newcastle-Ottawa Scale (NOS) was used to assess the study's quality. Results The initial search yielded 95 studies, of which 30 studies were included in the current systematic review. The underlying disorders were obesity, type 2 diabetes, breast and colorectal cancers, depression, and metabolic syndrome. These studies found an association between FTO gene polymorphisms and obesity in the Iranian population, but the relationship with other NCDs was debatable. Even though, other diseases such as diabetes and metabolic syndrome, which are closely related to obesity, may also be associated with FTO gene polymorphisms. Conclusion FTO gene polymorphism appears to play a role in the occurrence of NCDs. Some of the study results may be misleading due to ethnic differences and the effect of other genetic factors on disease onset, which needs to be investigated further. Finally, FTO gene polymorphisms can be studied as a preventive or therapeutic target.
C1 [Tavassol, Zahra Hoseini; Mousavi, Seyed Mohammad; Molaei, Bahareh; Ejtahed, Hanieh-Sadat; Khalagi, Kazem; Ghannadi, Shima; Hasani-Ranjbar, Shirin] Univ Tehran Med Sci, Obes & Eating Habits Res Ctr, Endocrinol & Metab Clin Sci Inst, Tehran, Iran.
   [Mousavi, Seyed Mohammad] Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Community Nutr, Tehran, Iran.
   [Bandarian, Fatemeh] Univ Tehran Med Sci, Metabol & Genom Res Ctr, Endocrinol & Metab Mol Cellular Sci Inst, Tehran, Iran.
   [Ejtahed, Hanieh-Sadat; Larijani, Bagher] Univ Tehran Med Sci, Endocrinol & Metab Res Ctr, Endocrinol & Metab Clin Sci Inst, Tehran, Iran.
   [Khalagi, Kazem] Univ Tehran Med Sci, Osteoporosis Res Ctr, Endocrinol & Metab Clin Sci Inst, Tehran, Iran.
   [Ghannadi, Shima] Univ Tehran Med Sci, Sports Med Res Ctr, Neurosci Inst, Tehran, Iran.
C3 Tehran University of Medical Sciences; Tehran University of Medical
   Sciences; Tehran University of Medical Sciences; Tehran University of
   Medical Sciences; Tehran University of Medical Sciences; Tehran
   University of Medical Sciences
RP Hasani-Ranjbar, S (corresponding author), Univ Tehran Med Sci, Obes & Eating Habits Res Ctr, Endocrinol & Metab Clin Sci Inst, Tehran, Iran.
EM shirinhasanir@yahoo.com
RI Mousavi, Seyed Mohammad/AAQ-7719-2020; larijani, Bagher/ABE-3315-2020;
   ejtahed, hanieh/AAH-4921-2021; Hoseini Tavassol, Zahra/HJP-2607-2023;
   Bandarian, F./ABW-4941-2022; Khalagi, Kazem/D-8192-2017
OI Ejtahed, Hanieh-Sadat/0000-0002-6395-4915; Hoseini Tavassol,
   Zahra/0000-0002-2432-2114
FU Endocrinology and Metabolism Research Institute, Tehran University of
   Medical Sciences, Tehran, Iran [1400-02-105-1164]
FX This study was funded by the Endocrinology and Metabolism Research
   Institute, Tehran University of Medical Sciences, Tehran, Iran (Number:
   1400-02-105-1164).
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NR 96
TC 0
Z9 0
U1 0
U2 6
PU SPRINGER INT PUBL AG
PI CHAM
PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND
EI 2251-6581
J9 J DIABETES METAB DIS
JI J. Diabetes Metab. Disord.
PD DEC
PY 2022
VL 21
IS 2
BP 1975
EP 1989
DI 10.1007/s40200-022-01139-4
EA OCT 2022
PG 15
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA 6G9RJ
UT WOS:000871514000001
PM 36404828
OA Green Published
DA 2025-06-11
ER

PT J
AU Kayikcioglu, M
   Saygi, S
   Azarsiz, E
   Can, LH
   Kultursay, H
   Sözmen, EY
AF Kayikcioglu, Meral
   Saygi, Serkan
   Azarsiz, Elif
   Can, Levent H.
   Kultursay, Hakan
   Sozmen, Eser Yildirim
TI Serum paraoxonase 1 activity and oxidative markers of LDL in patients
   with cardiac syndrome X
SO ACTA CARDIOLOGICA
LA English
DT Article
DE cardiac syndrome X; paraoxonase; LDL oxidation markers;
   endothelium-dependent vasodilotion
ID ENDOTHELIAL FUNCTION; ARTERIES
AB Objective - Myocardial ischaemia in cardiac syndrome X (CSX) is believed to be due to microvascular dysfunction. Increased oxidative stress is one of the suspected mechanisms of microvascular dysfunction. The aim of this study was to evaluate the oxidative status in patients with CSX, by determining serum paraoxonase-1 (PON1) activity in addition to LDL-oxidation markers.
   Methods and results - This cross-sectional study consisted of patients with CSX (group I, n = 30), patients with coronary artery disease (group II, n = 31), and healthy controls (group III, n = 32). Lipid parameters, PON-1 activity, and LDL oxidation markers (conjugated-diene and thiobarbituric acid-reactive substance-TBARS) were measured. Endothelium-dependent vasodilatation was determined by brachial artery ultrasonography. There were no significant differences in serum LDL, apolipoprotein-B, baseline LDL-diene, and LDL-TBARS levels between groups. There were no differences in both apolipoprotein-Al and HDL levels between group I and group III. Apolipoprotein-Al and HDL levels were significantly lower in group II than group I patients (P < 0.001). PON-1 activity was lowest in group II patients. Average PON-1 activity in group I was in between of group II and group III. The percent change of LDL-diene levels after stimulation was significantly higher in group II than in groups I and III (P = 0.005 and P = 0.02, respectively). The percent change of LDL-TBARS levels was lowest in group I (P=0.03). There was a moderate correlation between endothelium-dependent vasodilatation and PON-1 activity in group I (r = 0.43, P = 0.04).
   Conclusions - Enhanced oxidative stress might be one of the causes of impaired endothelial functions resulting in myocardial ischaemia and chest pain in patients with CSX. The relatively preserved HDL and apolipoprotein-Al levels in patients with CSX might be a protective mechanism against progression of coronary microvascular dysfunction to atherosclerotic coronary artery disease.
C1 Ege Univ, Sch Med, Dept Cardiol, Izmir, Turkey.
   Ege Univ, Sch Med, Dept Biochem, Izmir, Turkey.
C3 Ege University; Ege University
RP Kayikcioglu, M (corresponding author), Gediz Cad 11-2 Bornova, TR-35040 Izmir, Turkey.
EM meral.kayikcioglu@ege.edu.tr
RI KAYIKCIOGLU, Meral/AAH-6687-2020; Azarsiz, Elif/J-2034-2015; Y. Sozmen,
   Eser/ABI-5243-2020
OI Azarsiz, Elif/0000-0002-2887-7029; Y. Sozmen, Eser/0000-0002-6383-6724
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NR 17
TC 6
Z9 6
U1 0
U2 13
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0001-5385
EI 1784-973X
J9 ACTA CARDIOL
JI Acta Cardiol.
PD JUN
PY 2007
VL 62
IS 3
BP 245
EP 249
DI 10.2143/AC.62.3.2020812
PG 5
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 179CT
UT WOS:000247267600005
PM 17608098
DA 2025-06-11
ER

PT J
AU Bozbulut, R
   Acar, ASS
   Döger, E
   Çamurdan, MO
   Bideci, A
AF Bozbulut, Rukiye
   Acar, Azime Sebnem Soysal
   Doger, Esra
   Camurdan, Mahmut Orhun
   Bideci, Aysun
TI The relationship between alexithymia, health literacy, and diet quality
   in obese adolescents
SO JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
LA English
DT Article
DE adolescent; alexithymia; diet quality; health-literacy; obesity
ID HOMEOSTASIS MODEL ASSESSMENT; INSULIN-RESISTANCE; ASSOCIATION;
   DEPRESSION; INDEX
AB Objectives: Alexithymia and low health literacy are the barriers of self-management. This study aims to examine the relationship between alexithymia, health literacy and diet quality in obese adolescents, and their effects on anthropometric and biochemical markers.Methods: The 20-item Toronto alexithymia scale (TAS-20) was used to determine the alexithymic traits of the adolescents, and "The Newest Vital Sign " (NVS) scales were used to determine their health literacy levels. Diet quality was evaluated with the Healthy Eating Index-2010 (HEI-2010).Results: 39.7% of the obese adolescents were alexithymic, and 69.4% of alexithymics and 35.1% of non-alexithymics had metabolic syndrome. Alexithymic adolescents were lack of adequate health literacy. There were positive correlations between alexithymia scores and insulin, triglyceride, systolic and diastolic blood pressure levels, and all anthropometric values except height (p < 0.05). There was a negative correlation between alexithymia scores and health literacy scores (p < 0.05). There were negative correlations between health literacy and alexithymia scores, insulin, total cholesterol, triglyceride, ALT, systolic, diastolic blood pressure levels and all anthropometric values except height, and positive correlation was observed between health literacy scores and diet quality (p < 0.05). Total HEI score was negatively correlated with waist circumference, neck circumference, body weight, BMI, triglyceride, AST, ALT, systolic and diastolic blood pressure, and positively correlated with health literacy and HDL levels (p < 0.05).Conclusions: As alexithymia severity increased in obese adolescents, the degree of obesity and the incidence of metabolic syndrome increased while the level of health literacy decreased. The increase in health literacy levels, on the other hand, decreased the level of alexithymia and increased the quality of the diet.
C1 [Bozbulut, Rukiye; Doger, Esra; Camurdan, Mahmut Orhun; Bideci, Aysun] Gazi Univ, Fac Med, Dept Pediat Endocrinol, Ankara, Turkiye.
   [Acar, Azime Sebnem Soysal] Gazi Univ, Fac Med, Dept Pediat Neurol, Ankara, Turkiye.
C3 Gazi University; Gazi University
RP Bozbulut, R (corresponding author), Gazi Univ, Fac Med, Dept Pediat Endocrinol, Ankara, Turkiye.
EM dyt_rukiye@hotmail.com
RI Döğer, Esra/AFE-9507-2022
OI Bozbulut, Rukiye/0000-0003-4317-9226
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NR 44
TC 1
Z9 1
U1 5
U2 15
PU WALTER DE GRUYTER GMBH
PI BERLIN
PA GENTHINER STRASSE 13, D-10785 BERLIN, GERMANY
SN 0334-018X
EI 2191-0251
J9 J PEDIATR ENDOCR MET
JI J. Pediatr. Endocrinol. Metab.
PD FEB 23
PY 2023
VL 36
IS 2
BP 137
EP 146
DI 10.1515/jpem-2022-0405
EA JAN 2023
PG 10
WC Endocrinology & Metabolism; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Pediatrics
GA 8F0XL
UT WOS:000906391400001
PM 36588297
DA 2025-06-11
ER

PT J
AU Li, P
   Quan, W
   Lu, D
   Wang, Y
   Zhang, HH
   Liu, SA
   Jiang, RC
   Zhou, YY
AF Li, Pan
   Quan, Wei
   Lu, Da
   Wang, Yan
   Zhang, Hui-Hong
   Liu, Shuai
   Jiang, Rong-Cai
   Zhou, Yu-Ying
TI Association between Metabolic Syndrome and Cognitive Impairment after
   Acute Ischemic Stroke: A Cross-Sectional Study in a Chinese Population
SO PLOS ONE
LA English
DT Article
ID ALZHEIMERS-DISEASE; VASCULAR DEMENTIA; ELDERLY-PEOPLE; OLDER-ADULTS;
   RISK; VERSION; AGE; INFLAMMATION; RELIABILITY; PERFORMANCE
AB Background and Objectives
   Metabolic syndrome (MetS), a risk factor for many vascular conditions, is associated with vascular cognitive disorders. The objective of the present study was to explore the associations of MetS and its individual components with the risks of cognitive impairment and neurological dysfunction in patients after acute stroke.
   Methods
   This cross-sectional study enrolled 840 patients ranging in age from 53 to 89 years from the Tianjin area of North China. Cognitive function was evaluated using the Montreal Cognitive Assessment (MoCA) and Mini-Mental State Examination. Neuropsychiatric behavior was assessed using the Neuropsychiatric Inventory Questionnaire. Emotional state was examined according to the Hamilton Depression Rating Scale, and neuromotor function was evaluated using the National Institutes of Health Stroke Scale, Barthel index, and the Activity of Daily Living test. After overnight fasting, blood samples were obtained to measure biochemistry indicators.
   Results
   MetS and its individual components were closely correlated with MoCA score. MetS patients had high levels of inflammation and a 3.542-fold increased odds ratio (OR) for cognitive impairment [95% confidence interval (CI): 1.972-6.361]. Of the individual MetS components, central obesity (OR 3.039; 95% CI: 1.839-5.023), high fasting plasma glucose (OR 1.915; 95% CI: 1.016-3.607), and type 2 diabetes (OR 2.241; 95% CI: 1.630-3.081) were associated with an increased incidence of cognitive impairment. Consistent and significant worsening in different neurological domains was observed with greater numbers of MetS components.
   Conclusions
   MetS was associated with worse cognitive function, neuromotor dysfunction, and neuropsychological symptoms among Chinese acute stroke patients.
C1 [Li, Pan; Lu, Da; Wang, Yan; Zhang, Hui-Hong; Liu, Shuai; Zhou, Yu-Ying] Tianjin Huanhu Hosp, Dept Neurol, Tianjin, Peoples R China.
   [Li, Pan; Lu, Da; Wang, Yan; Zhang, Hui-Hong; Liu, Shuai; Zhou, Yu-Ying] Tianjin Huanhu Hosp, Tianjin Neurosurg Inst, Tianjin Key Lab of Cerebral Vasc & Neurodegenerat, Tianjin, Peoples R China.
   [Quan, Wei; Jiang, Rong-Cai] Tianjin Med Univ, Gen Hosp, Dept Neurosurg, Tianjin, Peoples R China.
   [Quan, Wei; Jiang, Rong-Cai] Gen Hosp, Minist Educ, Tianjin Neurol Inst, Key Lab Posttrauma Neurorepair & Regenerat Cent N, Tianjin, Peoples R China.
   [Quan, Wei; Jiang, Rong-Cai] Gen Hosp, Tianjin Key Lab Injuries Variat & Regenerat Nervo, Tianjin, Peoples R China.
C3 Tianjin Medical University; Ministry of Education - China
RP Li, P; Zhou, YY (corresponding author), Tianjin Huanhu Hosp, Dept Neurol, Tianjin, Peoples R China.; Li, P; Zhou, YY (corresponding author), Tianjin Huanhu Hosp, Tianjin Neurosurg Inst, Tianjin Key Lab of Cerebral Vasc & Neurodegenerat, Tianjin, Peoples R China.
EM doc_panpan@163.com; professor_yyzhou@163.com
FU Science and Technology Project of the Tianjin Municipal Health Bureau
   [2013KG121]; Tianjin Science and Technology Plan Foundation
   [13ZCZDSY01600]; National Clinical and Medical Research [L2014071];
   National Nature Science Foundation of China [81301629]
FX This work was supported by the Science and Technology Project of the
   Tianjin Municipal Health Bureau
   (http://www.tjwsj.gov.cn/html/WSJn/portal/index/index.htm) (2013KG121),
   the Tianjin Science and Technology Plan Foundation
   (http://www.tstc.gov.cn/) (grant no. 13ZCZDSY01600), the Special Fund of
   National Clinical and Medical Research (http://www.nsfc.gov.cn/) (grant
   no. L2014071), the Youth fund of National Nature Science Foundation of
   China (http://www.nsfc.gov.cn/) (grant no. 81301629). The funders had no
   role in study design, data collection and analysis, decision to publish,
   or preparation of the manuscript.
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NR 39
TC 20
Z9 21
U1 0
U2 24
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD DEC 9
PY 2016
VL 11
IS 12
AR e0167327
DI 10.1371/journal.pone.0167327
PG 13
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA EE4PU
UT WOS:000389587100086
PM 27936074
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Zhang, XE
   Cheng, B
   Wang, Q
   Wan, JJ
AF Zhang, Xiu-E
   Cheng, Bei
   Wang, Qian
   Wan, Jing-Jing
TI Association of gender-specific risk factors in metabolic and
   cardiovascular diseases: an NHANES-based cross-sectional study
SO JOURNAL OF INVESTIGATIVE MEDICINE
LA English
DT Article
ID VITAMIN-D; 25-HYDROXYVITAMIN D; NATIONAL-HEALTH; ADIPOSE-TISSUE;
   DEPRESSION; PREVALENCE; INTENSITY; EXERCISE; OBESITY; DIAGNOSIS
AB In the present cross-sectional study, based on National Health and Nutrition Examination Survey (NHANES, 2007-2010) cohorts, various risk factors for metabolic syndrome (MetS) and cardiovascular diseases (CVDs) were analyzed (n=12,153). The variables analyzed include, demographics, comorbidities associated with MetS or CVD, behavioral and dietary factors, while the primary endpoints were the prevalence of MetS and CVD. The prevalence of MetS and CVD was slightly higher in males as compared with females (42.50% and 7.65% vs 41.29% and 4.13%, respectively). After controlling for confounding factors, advanced age, family history of diabetes mellitus (DM), overweight, and obesity were significantly associated with the likelihood of MetS, irrespective of gender differences. In males, the diagnosis of prostate cancer and regular smoking were additional risk factors of MetS, whereas, advanced age, family history of heart attack or angina, health insurance coverage, diagnosis of rheumatoid arthritis or depression, obesity and low calorie intake were identified as risk factors for CVD. In addition to the above risk factors, higher physical activity and vitamin D insufficiency were also found to increase the risk of CVD in females. Furthermore, obesity was a higher risk factor for MetS than CVD. Emerging risk factors for CVD identified in this study has major clinical implications. Of interest is the correlation of higher physical activity and the risk of CVD in women and the role of depression and lower calorie intake in general population.
C1 [Zhang, Xiu-E; Cheng, Bei; Wang, Qian; Wan, Jing-Jing] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Geriatr, Wuhan, Hubei, Peoples R China.
   [Zhang, Xiu-E; Cheng, Bei; Wang, Qian; Wan, Jing-Jing] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Inst Geriatr, Wuhan, Hubei, Peoples R China.
C3 Huazhong University of Science & Technology; Huazhong University of
   Science & Technology
RP Zhang, XE (corresponding author), Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Inst Geriatr,Dept Geriatr, Wuhan 430022, Hubei, Peoples R China.
EM zxe331@macsohu.com
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NR 44
TC 12
Z9 12
U1 0
U2 13
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 1081-5589
EI 1708-8267
J9 J INVEST MED
JI J. Invest. Med.
PD JAN
PY 2018
VL 66
IS 1
BP 22
EP 31
DI 10.1136/jim-2017-000434
PG 10
WC Medicine, General & Internal; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Research & Experimental Medicine
GA GF5LA
UT WOS:000432007400007
PM 28866631
DA 2025-06-11
ER

PT J
AU Nishimura, N
   Tanabe, H
   Adachi, M
   Yamamoto, T
   Fukushima, M
AF Nishimura, Naomichi
   Tanabe, Hiroki
   Adachi, Misato
   Yamamoto, Tatsuro
   Fukushima, Michihiro
TI Colonic Hydrogen Generated from Fructan Diffuses into the Abdominal
   Cavity and Reduces Adipose mRNA Abundance of Cytokines in Rats
SO JOURNAL OF NUTRITION
LA English
DT Article
ID CHAIN FATTY-ACIDS; ISCHEMIA-REPERFUSION INJURY; OXIDATIVE STRESS;
   METABOLIC SYNDROME; RICH SALINE; MOLECULAR-HYDROGEN; BREATH HYDROGEN;
   GAS-PRODUCTION; FERMENTATION; INHALATION
AB Hydrogen (H-2) protects against inflammation-induced oxidative stress. Nondigestible saccharides (NDSs) enhance colonic H-2 production. We examined whether colonic H-2 transfers to tissues in the abdominal cavity and whether it affects expression of proinflammatory cytokines. In Expts. 1 and 2, rats were fed diets containing fructooligosaccharides [FOSs; 25 (Expt. 1) and 50 g/kg (Expts. 1 and 2)] for 7 and 14 d, respectively. The no-FOS diet was used as the control diet. At the end of the experiment, H2 excretion and the portal H-2 concentration were significantly greater in the FOS group than in the control group. In the FOS group, the arterial H-2 concentration was no more than 1.5% of the portal H-2 concentration (P = 0.03). The H-2 concentration in abdominal cavity tissues, especially adipose tissue, in the FOS group was 5.6- to 43-fold of that in the control group (P < 0.05). The H-2 content in the abdominal cavity in the FOS group was 11-fold of that in the control group (P < 0.05). In Expt. 3, rats were fed a high-fat diet containing FOS and inulin (50 g/kg) for 28 d. The area under the curve for H-2 excretion between 0 and 28 d and portal and adipose H-2 concentrations were significantly higher in the FOS and inulin groups than in the high-fat control group. Adipose mRNA abundance of nuclear factor kappa-light-chain-enhancer of activated B cells 1 was lower in the FOS group than in the control group (P = 0.02) and those of interleukin-6 and chemokine (C-C motif) ligand 2 tended to be lower (P < 0.11). Colonic H-2 generated from NDS diffuses to the abdominal cavity before transferring to abdominal tissues. Reduced cytokine expression by FOS feeding might be dependent on increased colonic H-2. Colonic H-2 may have important implications in the suppressive effect on metabolic syndrome via oxidative stress.
C1 [Nishimura, Naomichi; Tanabe, Hiroki; Adachi, Misato; Yamamoto, Tatsuro] Nayoro City Univ, Fac Hlth & Welf Sci, Dept Nutr Sci, Nayoro, Hokkaido, Japan.
   [Fukushima, Michihiro] Obihiro Univ Agr & Vet Med, Dept Anim Sci, Obihiro, Hokkaido 080, Japan.
C3 Obihiro University of Agriculture & Veterinary Medicine
RP Nishimura, N (corresponding author), Nayoro City Univ, Fac Hlth & Welf Sci, Dept Nutr Sci, Nayoro, Hokkaido, Japan.
EM nishimura@nayoro.ac.jp
RI Nishimura, Naomichi/AAJ-3144-2020
OI Nishimura, Naomichi/0000-0002-6459-726X
FU Ministry of Education, Culture, Sports, Science and Technology, Japan;
   Grants-in-Aid for Scientific Research [24500981] Funding Source: KAKEN
FX Supported in part by a Regional Innovation Strategy Support Program
   "Tokachi Agricultural Bioscience Cluster" of the Ministry of Education,
   Culture, Sports, Science and Technology, Japan.
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NR 35
TC 23
Z9 25
U1 0
U2 6
PU AMER SOC NUTRITION-ASN
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-3166
EI 1541-6100
J9 J NUTR
JI J. Nutr.
PD DEC
PY 2013
VL 143
IS 12
BP 1943
EP 1949
DI 10.3945/jn.113.183004
PG 7
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 260CB
UT WOS:000327571500011
PM 24132574
OA Bronze
DA 2025-06-11
ER

PT J
AU Spikes, T
   Higgins, M
   Quyyumi, A
   Reilly, C
   Pemu, P
   Dunbar, S
AF Spikes, Telisa
   Higgins, Melinda
   Quyyumi, Arshed
   Reilly, Carolyn
   Pemu, Pricilla
   Dunbar, Sandra
TI The Relationship Among Health Beliefs, Depressive Symptoms, Medication
   Adherence, and Social Support in African Americans With Hypertension
SO JOURNAL OF CARDIOVASCULAR NURSING
LA English
DT Article
DE African Americans; hypertension; hypertension beliefs; medication
   adherence
ID BLOOD-PRESSURE CONTROL; METABOLIC SYNDROME; CARE; PREDICTORS; BARRIERS;
   NONADHERENCE; FACILITATORS; ANTECEDENTS; PREVALENCE; MANAGEMENT
AB Background: African Americans are disproportionately affected by hypertension and have lower medication adherence when compared to other racial groups. Antecedent factors such as beliefs surrounding hypertension, the presence or absence of social support, and depressive symptoms have not been extensively studied collectively in relation to hypertension medication adherence in African Americans. Objective: To determine the associations among demographic and clinical factors, depressive symptoms, hypertension beliefs, and social support with blood pressure medication adherence in middle-aged African American adults with a diagnosis of hypertension. Methods: A cross-sectional study of (N = 120) African Americans (mean age, 49 years; 22.5% men) with a current diagnosis of metabolic syndrome, including hypertension, who reported having and taking a prescribed blood pressure-lowering medication were included. Descriptive statistics, bivariate correlation analysis, and logistic regression using odds ratio were used to examine the effects of high blood pressure beliefs, social support, and depression on medication adherence. Results: A small but significant relationship was found between medication adherence and number of comorbidities (r = 0.19, P = .04). In a multivariate regression model, after controlling for gender, comorbidities remained associated with medication adherence (beta = 0. 77, P = .04). Depressive symptoms, high blood pressure beliefs, and social support did not have a significant relationship with medication adherence. Conclusions: Multiple comorbidities may have a positive impact upon medication adherence. Further study is needed in a larger sample of African Americans who have a diagnosis of hypertension in addition to other comorbidities requiring medication management.
C1 [Spikes, Telisa; Reilly, Carolyn] Emory Univ, Nell Hodgson Woodruff Sch Nursing, 1520 Clifton Rd,NE, Atlanta, GA 30322 USA.
   [Higgins, Melinda] Emory Univ, Nell Hodgson Woodruff Sch Nursing, Biostat, Atlanta, GA 30322 USA.
   [Quyyumi, Arshed] Emory Univ, Emory Clin Cardiovasc Res Inst, Div Cardiol, Med, Atlanta, GA 30322 USA.
   [Pemu, Pricilla] Morehouse Sch Med, Atlanta, GA 30310 USA.
   [Dunbar, Sandra] Emory Univ, Nell Hodgson Woodruff Sch Nursing, Acad Adv, Atlanta, GA 30322 USA.
C3 Emory University; Emory University; Emory University; Morehouse School
   of Medicine; Emory University
RP Spikes, T (corresponding author), Emory Univ, Nell Hodgson Woodruff Sch Nursing, 1520 Clifton Rd,NE, Atlanta, GA 30322 USA.
EM tspikes@emory.edu
RI Higgins, Melinda/B-6459-2013; Reilly, Carolyn/AGH-4208-2022; Spikes,
   Telisa/IWE-0022-2023
OI Spikes, Telisa/0000-0002-0105-1382; Reilly, Carolyn/0000-0003-1641-1747
FU National Heart, Lung, and Blood Institute (NIH) [1 U01 HL079156-01]; PHS
   Grant from the Clinical and Translational Science Award program, NIH,
   NCRR [UL1 RR025008]; NIH, National Center for Research Resources for the
   Morehouse Clinical Research Center [5P20RR11104]; National Institutes of
   Health National Institute of Nursing Research [T32NR012715]
FX This study was supported by the National Heart, Lung, and Blood
   Institute (NIH; 1 U01 HL079156-01; Dr Quyyumi, PI); PHS Grant UL1
   RR025008 from the Clinical and Translational Science Award program, NIH,
   NCRR; and grant 5P20RR11104 from the NIH, National Center for Research
   Resources for the Morehouse Clinical Research Center. Effort for T.
   Spikes was funded in part by the National Institutes of Health National
   Institute of Nursing Research grant number T32NR012715 (PI, S. Dunbar).
   The content is solely the responsibility of the authors and does not
   necessarily represent the official views of the NIH.
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NR 59
TC 13
Z9 29
U1 0
U2 8
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0889-4655
EI 1550-5049
J9 J CARDIOVASC NURS
JI J. Cardiovasc. Nurs.
PD JAN-FEB
PY 2019
VL 34
IS 1
BP 44
EP 51
DI 10.1097/JCN.0000000000000519
PG 8
WC Cardiac & Cardiovascular Systems; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Cardiovascular System & Cardiology; Nursing
GA IQ5LY
UT WOS:000480795300010
PM 30273259
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Viscogliosi, G
   Chiriac, IM
   Andreozzi, P
   Ettorre, E
AF Viscogliosi, Giovanni
   Chiriac, Iulia Maria
   Andreozzi, Paola
   Ettorre, Evaristo
TI Executive dysfunction assessed by Clock-Drawing Test in older
   non-demented subjects with metabolic syndrome is not mediated by white
   matter lesions
SO PSYCHIATRY AND CLINICAL NEUROSCIENCES
LA English
DT Article
DE Clock-Drawing Test; executive dysfunction; metabolic syndrome;
   prevention; white matter hyperintensities
ID MINI-MENTAL-STATE; ALZHEIMERS-DISEASE; COGNITIVE DECLINE; DEMENTIA;
   RISK; ASSOCIATION; POPULATION; DEPRESSION; SCALE
AB AimsMetabolic syndrome (MetS) has been associated with greater occurrence of white matter hyperintensities (WMH). It remains uncertain whether MetS as a construct is associated with poorer cognitive performances. This study explores whether MetS is associated with poorer performances in global and domain-specific cognitive tests in older non-demented subjects independently of its individual components, WMH severity and other variables.
   MethodsMetS was diagnosed according to the National Cholesterol Education Program Adult Treatment Panel III definition. Brain magnetic resonance studies (1.5T) were performed. Deep and periventricular WMH were graded using the Fazekas scale. Subjects underwent the Mini-Mental State Examination, the Babcock Short Story Recall test and the Clock-Drawing Test (CDT).
   ResultsEighty community-dwellers aged 67-91 years were studied. Subjects with MetS (n=35) had more severe WMH, and poorer performances on the CDT (P=0.003) and the Babcock Short Story Recall test (P=0.027). After multiple adjustment, MetS was inversely associated with CDT scores (B=-1.285; 95% confidence interval=-1.996--0.575; P=0.001) but not with episodic memory. Results were not affected by WMH severity. Interestingly, none of the individual components of MetS predicted poorer cognitive performances.
   ConclusionsImpairment in executive functions assessed by CDT may represent an early and specific sign of cognitive decline in older individuals with MetS. Future longitudinal studies are needed to better establish the predictive role of MetS on dementia and to demonstrate the possibility of dementia prevention by targeting MetS.
C1 [Viscogliosi, Giovanni; Andreozzi, Paola; Ettorre, Evaristo] Univ Roma La Sapienza, Dept Cardiovasc Resp Nephrol Anesthesiol & Geriat, Div Gerontol, I-00100 Rome, Italy.
   [Chiriac, Iulia Maria] Natl Inst Hlth, Div Geriatr, Rome, Italy.
   [Viscogliosi, Giovanni] Natl Inst Hlth, Dept Epidemiol Surveillance & Promot Hlth, Rome, Italy.
C3 Sapienza University Rome; Istituto Superiore di Sanita (ISS); Istituto
   Superiore di Sanita (ISS)
RP Viscogliosi, G (corresponding author), Univ Roma La Sapienza, Dept Cardiovasc Resp Nephrol Anesthesiol & Geriat, Viale Policlin 155, I-00100 Rome, Italy.
EM giovanni.viscogliosi@libero.it
OI Andreozzi, Paola/0000-0003-0369-8750; ettorre,
   evaristo/0000-0002-8247-3308
CR [Anonymous], 2000, DIAGN STAT MAN MENT
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NR 34
TC 15
Z9 16
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1323-1316
EI 1440-1819
J9 PSYCHIAT CLIN NEUROS
JI Psychiatry Clin. Neurosci.
PD OCT
PY 2015
VL 69
IS 10
BP 620
EP 629
DI 10.1111/pcn.12296
PG 10
WC Clinical Neurology; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA CS9NY
UT WOS:000362419000003
PM 25781474
OA Bronze
DA 2025-06-11
ER

PT J
AU Busse, S
   Bernstein, HG
   Busse, M
   Bielau, H
   Brisch, R
   Mawrin, C
   Müller, S
   Sarnyai, Z
   Gos, T
   Bogerts, B
   Steiner, J
AF Busse, Stefan
   Bernstein, Hans-Gert
   Busse, Mandy
   Bielau, Hendrik
   Brisch, Ralf
   Mawrin, Christian
   Mueller, Susan
   Sarnyai, Zoltan
   Gos, Tomasz
   Bogerts, Bernhard
   Steiner, Johann
TI Reduced density of hypothalamic VGF-immunoreactive neurons in
   schizophrenia: a potential link to impaired growth factor signaling and
   energy homeostasis
SO EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
LA English
DT Article
DE Schizophrenia; Hypothalamus; Postmortem; Histopathology; VGF; Granins
ID METABOLIC SYNDROME; EXPRESSION; PEPTIDES; GENE; DEPRESSION; BIOMARKERS;
   DISORDERS; PROTEIN; SERUM
AB Protein expression of VGF (nonacronymic) is induced by nerve/brain-derived growth factor, neurotrophin 3, and insulin. VGF is synthesized by neurons in the paraventricular (PVN) and supraoptic (SON) nuclei of the hypothalamus. After enzymatic processing, smaller VGF-derived peptides are secreted into the cerebrospinal fluid (CSF) or blood. These peptides play important roles by improving synaptic plasticity, neurogenesis, and energy homeostasis, which are impaired in schizophrenia. Based on previous observations of neuroendocrine and hypothalamic deficits in schizophrenia and to determine whether increased levels of the VGF fragment 23-62 in CSF, which have been described in a recent study, were related to changes in hypothalamic VGF expression, an immunohistochemical study was performed in 20 patients with schizophrenia and 19 matched control subjects. N- (D-20) and C-terminal (R-15) VGF antibodies yielded similar results and immunolabeled a vast majority of PVN and SON neurons. Additionally, D20-VGF immunohistochemistry revealed immunostained fibers in the pituitary stalk and neurohypophysis that ended at vessel walls, suggesting axonal transport and VGF secretion. The cell density of D20-VGF-immunoreactive neurons was reduced in the left PVN (P = 0.002) and SON (P = 0.008) of patients with schizophrenia. This study provides the first evidence for diminished hypothalamic VGF levels in schizophrenia, which might suggest increased protein secretion. Our finding was particularly significant in subjects without metabolic syndrome (patients with a body mass index a parts per thousand currency sign28.7 kg/m(2)). In conclusion, apart from beneficial effects on synaptic plasticity and neurogenesis, VGF may be linked to schizophrenia-related alterations in energy homeostasis.
C1 [Busse, Stefan; Bernstein, Hans-Gert; Bielau, Hendrik; Brisch, Ralf; Mueller, Susan; Gos, Tomasz; Bogerts, Bernhard; Steiner, Johann] Univ Magdeburg, Dept Psychiat, D-39120 Magdeburg, Germany.
   [Busse, Mandy] Hannover Med Sch, Dept Pediat Pulmonol & Allergol, Hannover, Germany.
   [Mawrin, Christian] Univ Magdeburg, Inst Neuropathol, D-39120 Magdeburg, Germany.
   [Sarnyai, Zoltan] Univ Cambridge, Dept Pharmacol, Cambridge CB2 1QJ, England.
   [Gos, Tomasz] Med Univ Gdansk, Inst Forens Med, Gdansk, Poland.
   [Steiner, Johann] Univ Cambridge, Pembroke Coll, Cambridge, England.
C3 Otto von Guericke University; Hannover Medical School; Otto von Guericke
   University; University of Cambridge; Fahrenheit Universities; Medical
   University Gdansk; University of Cambridge
RP Steiner, J (corresponding author), Univ Magdeburg, Dept Psychiat, Leipziger Str 44, D-39120 Magdeburg, Germany.
EM johann.steiner@med.ovgu.de
RI Sarnyai, Zoltan/A-3283-2009; Gos, Tomasz/AAC-2910-2020
OI Steiner, Johann/0000-0002-2611-2268; Brisch, Ralf/0000-0002-6677-8339;
   Sarnyai, Zoltan/0000-0002-2380-7902; Gos, Tomasz/0000-0003-0161-9270
FU Stanley Medical Research Foundation [07R-1832]
FX Pembroke College (University of Cambridge, Cambridge, UK) has invited JS
   for a Visiting Scholarship. This work was supported in part by the
   Stanley Medical Research Foundation to BB and JS (Grant No. 07R-1832).
   We are grateful to Henrik Dobrowolny for his skillful assistance in
   statistical analysis. Bianca Jerzykiewicz, Kathrin Paelchen, and Renate
   Stauch provided excellent technical assistance.
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NR 41
TC 20
Z9 21
U1 1
U2 9
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0940-1334
EI 1433-8491
J9 EUR ARCH PSY CLIN N
JI Eur. Arch. Psych. Clin. Neurosci.
PD AUG
PY 2012
VL 262
IS 5
BP 365
EP 374
DI 10.1007/s00406-011-0282-7
PG 10
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Psychiatry
GA 985ZP
UT WOS:000307309300002
PM 22167530
DA 2025-06-11
ER

PT J
AU Ayub, A
   Ashfaq, UA
   Haque, A
AF Ayub, Ambreen
   Ashfaq, Usman Ali
   Haque, Asma
TI HBV Induced HCC: Major Risk Factors from Genetic to Molecular Level
SO BIOMED RESEARCH INTERNATIONAL
LA English
DT Review
ID HEPATITIS-B-VIRUS; HUMAN HEPATOCELLULAR-CARCINOMA; METABOLIC SYNDROME
   INCREASES; CHRONIC LIVER-DISEASE; X-PROTEIN; GROWTH-FACTOR; OXIDATIVE
   STRESS; SURFACE-ANTIGEN; CELL-CYCLE; PROMOTER POLYMORPHISMS
AB Hepatocellular carcinoma (HCC) is a deadly and emerging disease leading to death in Asian countries. High hepatitis B virus (HBV) load and chronic hepatitis B (CHB) infection increase the risk of developing HCC. HBV is a DNA virus that can integrate DNA into host genome thereby increase the yield of transactivator protein HBxAg that may deregulate many pathways involving in metabolism of cells. Several monogenic and polygenic risk factors are also involved in HCC development. This review summarizes the mechanism involved in HCC development and discusses some promising therapies to make HCC curative.
C1 [Ayub, Ambreen; Ashfaq, Usman Ali; Haque, Asma] Govt Coll Univ Faisalabad, Dept Bioinformat & Biotechnol, Faisalabad 38000, Pakistan.
C3 Government College University Faisalabad
RP Ashfaq, UA (corresponding author), Govt Coll Univ Faisalabad, Dept Bioinformat & Biotechnol, Faisalabad 38000, Pakistan.
EM usmancemb@gmail.com
RI Ashfaq, Prof.Dr. Usman Ali/D-7792-2013
OI Ashfaq, Prof.Dr. Usman Ali/0000-0002-5495-805X
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NR 172
TC 50
Z9 55
U1 0
U2 10
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2314-6133
EI 2314-6141
J9 BIOMED RES INT
JI Biomed Res. Int.
PY 2013
VL 2013
AR 810461
DI 10.1155/2013/810461
PG 14
WC Biotechnology & Applied Microbiology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Research & Experimental Medicine
GA 203JX
UT WOS:000323289800001
PM 23991421
OA hybrid, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Diène, E
   Fouquet, A
   Esquirol, Y
AF Diene, Eloi
   Fouquet, Aurelie
   Esquirol, Yolande
TI Cardiovascular diseases and psychosocial factors at work
SO ARCHIVES OF CARDIOVASCULAR DISEASES
LA English
DT Review
DE Cardiovascular diseases; Job strain; Effort reward imbalance;
   Psychosocial factors at work
ID CORONARY-HEART-DISEASE; AMBULATORY BLOOD-PRESSURE; EFFORT-REWARD
   IMBALANCE; JOB STRAIN; RISK-FACTORS; MYOCARDIAL-INFARCTION;
   ISCHEMIC-HEART; STRESS; MEN; MORTALITY
AB Besides the 'classic' cardiovascular risk factors (high blood pressure, dyslipidaemia, metabolic syndrome and diabetes), the work environment is playing an increasingly significant role in cardiovascular morbidity and mortality. Several elements contribute to the effect of the work environment: physical factors, chemical factors, shift work and psychosocial factors. The effects of psychosocial factors on the aetiology and progression of cardiovascular disease have been confirmed by several studies. Identification of these work-related psychosocial factors must be taken into account when evaluating cardiovascular risk factors, in order to ensure better prevention. (C) 2011 Elsevier Masson SAS. All rights reserved.
C1 [Diene, Eloi; Fouquet, Aurelie] Inst Veille Sanitaire InVS, Dept Sante Travail, F-94415 St Maurice, France.
   [Esquirol, Yolande] Toulouse III Paul Sabatier Univ, Sch Med, Dept Epidemiol, INSERM,U1027, F-31000 Toulouse, France.
   [Esquirol, Yolande] CHU Toulouse, Hop Purpan, Serv Maladies Professionnelles & Environnem, F-31000 Toulouse, France.
C3 Sante publique France; Institut National de la Sante et de la Recherche
   Medicale (Inserm); Universite de Toulouse; Universite Toulouse III -
   Paul Sabatier; CHU de Toulouse; Universite de Toulouse; Universite
   Toulouse III - Paul Sabatier
RP Diène, E (corresponding author), Inst Veille Sanitaire, Dept Sante Travail, 10 Chemin Raisin, F-31050 Toulouse 9, France.
EM diene@cict.fr
RI Esquirol, yolande/KEE-9367-2024; Esquirol, Yolande/E-4177-2017
OI Esquirol, Yolande/0000-0002-2235-0330
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NR 56
TC 19
Z9 24
U1 1
U2 25
PU ELSEVIER MASSON, CORP OFF
PI PARIS
PA 65 CAMILLE DESMOULINS CS50083 ISSY-LES-MOULINEAUX, 92442 PARIS, FRANCE
SN 1875-2136
EI 1875-2128
J9 ARCH CARDIOVASC DIS
JI Arch. Cardiovasc. Dis.
PD JAN
PY 2012
VL 105
IS 1
BP 33
EP 39
DI 10.1016/j.acvd.2011.10.001
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Cardiovascular System & Cardiology
GA 921PW
UT WOS:000302490500006
PM 22369916
OA Bronze
DA 2025-06-11
ER

PT J
AU Al-kuraishy, HM
   Jabir, MS
   Al-Gareeb, AI
   Albuhadily, AK
AF Al-kuraishy, Hayder M.
   Jabir, Majid S.
   Al-Gareeb, Ali I.
   Albuhadily, Ali K.
TI New insight on the possible role of statins in Vascular Parkinsonism: A
   need for presumptive therapy
SO AGEING RESEARCH REVIEWS
LA English
DT Review
DE Vascular Parkinsonism; Subcortical lacunar infarct; Inflammatory and
   oxidative stress; Statins
ID WHITE-MATTER HYPERINTENSITIES; ISCHEMIC-STROKE; CEREBROVASCULAR LESIONS;
   DISEASE; PATHOLOGY; NEUROPROTECTION; ENDOTHELIN-1; PROGRESSION;
   PREVALENCE; DIAGNOSIS
AB Vascular Parkinsonism (VP) is clinical term represents a progressive ischemic changes and subcortical lacunar infarct leading to Parkinsonism mainly in the lower limbs so called lower body Parkinsonism. The VP neuropathology is differed from that of PD neuropathology which rarely associated with basal ganglion lesions. Dopamine transporters are normal in VP but are highly reduced in PD, and dopaminergic agonists had no effective role on VP. The neuropathological mechanisms of VP are related to vascular injury which induces the interruption of the neural connection between basal ganglion and cerebral cortex. Hyperlipidemia and other cardiometabolic risk factors augment VP risk and the related neuropathology. Targeting of these cardiometabolic disorders by lipid-lowering statins may be effective in the management of VP. Therefore, this mini-review aims to clarify the possible role of statins in the management of VP. Statins have neuroprotective effects against different neurodegenerative diseases by anti-inflammatory, antioxidant and antithrombotic effects with enhancement of endothelial function. In conclusion, statins can prevent and treat VP by inhibiting inflammatory and oxidative stress disorders, mitigating of white matter hyperintensities and improving of neuronal signaling pathways. Additional preclinical, clinical trials and prospective studies are warranted in this regard.
C1 [Al-kuraishy, Hayder M.; Al-Gareeb, Ali I.; Albuhadily, Ali K.] Mustansiriyah Univ, Coll Med, Dept Clin Pharmacol & Med, Baghdad, Iraq.
   [Jabir, Majid S.] Univ Technol Baghdad, Dept Appl Sci, Baghdad, Iraq.
C3 Mustansiriya University; University of Technology- Iraq
RP Jabir, MS (corresponding author), Univ Technol Baghdad, Dept Appl Sci, Baghdad, Iraq.
EM 100131@uotechnology.edu.iq
RI Jabir, Majid/J-9683-2019; al-kuraishy, hayder/AAE-6673-2019; Al-Gareeb,
   Ali/I-8330-2019
OI Al-Gareeb, Ali/0000-0001-8284-8897
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NR 93
TC 15
Z9 15
U1 2
U2 4
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 1568-1637
EI 1872-9649
J9 AGEING RES REV
JI Ageing Res. Rev.
PD MAR
PY 2024
VL 95
AR 102209
DI 10.1016/j.arr.2024.102209
EA FEB 2024
PG 6
WC Cell Biology; Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Geriatrics & Gerontology
GA KZ8U0
UT WOS:001183890300001
PM 38286334
DA 2025-06-11
ER

PT J
AU Lin, YH
   Chiou, JM
   Chen, TF
   Lai, LC
   Chen, JH
   Chen, YC
AF Lin, Yi-Hsuan
   Chiou, Jeng-Min
   Chen, Ta-Fu
   Lai, Liang-Chuan
   Chen, Jen-Hau
   Chen, Yen-Ching
TI The association between metabolic syndrome and successful aging- using
   an extended definition of successful aging
SO PLOS ONE
LA English
DT Article
ID MONTREAL COGNITIVE ASSESSMENT; CARDIOVASCULAR-DISEASE;
   INSULIN-RESISTANCE; OLDER PERSONS; INFLAMMATION; DEPRESSION; HEALTH;
   RISK; POPULATION; PREVALENCE
AB Objectives To examine the association between metabolic syndrome (MetS) and successful aging among community-dwelling older adults.
   Methods Adults aged >= 65 years who participated in the senior health checkup program at National Taiwan University Hospital during 2011-2013 were recruited (N = 467 at baseline). The participants were followed after 4 years and 6 years. MetS was assessed at baseline. Successful aging was evaluated at baseline, 4-year follow-up, and 6-year follow-up. We adopted an extended definition of successful aging, which was defined as three major domains: physiological, psychological, and sociological and economic domains. Generalized linear mixed models were used to assess the association between MetS and successful aging adjusting for time (follow-up years), age, sex, years of education, alcohol consumption and MetSxtime interaction term.
   Results The mean age of the study population was 72.9 (SD 5.5) years. The absence of baseline MetS had a positive effect on the probability of successful aging over six years. The absences of abdominal obesity, hyperglycemia, reduced high-density lipoprotein cholesterol, and hypertension were associated with the physiological successful aging. The absence of hypertension was the most significant predictor of physiological successful aging [aOR (95% CI) = 2.76 (1.67-4.58), p<0.001]. Significant increased trend was found in the overall and physiological successful aging across MetS status (No MetS, pre MetS, MetS; P-trend <0.001).
   Conclusions We found that MetS is a risk factor of successful aging among community-dwelling older adults. Public health policy should aim at avoidance of MetS in order to facilitate successful aging in older population.
C1 [Lin, Yi-Hsuan] Cheng Hsin Gen Hosp, Dept Family Med, Taipei, Taiwan.
   [Lin, Yi-Hsuan] Natl Yang Ming Chiao Tung Univ, Sch Med, Dept Family Med, Taipei, Taiwan.
   [Chiou, Jeng-Min] Acad Sinica, Inst Stat Sci, Taipei, Taiwan.
   [Chen, Ta-Fu] Natl Taiwan Univ Hosp, Dept Neurol, Taipei, Taiwan.
   [Lai, Liang-Chuan] Natl Taiwan Univ, Coll Med, Grad Inst Physiol, Taipei, Taiwan.
   [Chen, Jen-Hau; Chen, Yen-Ching] Natl Taiwan Univ, Coll Publ Hlth, Inst Epidemiol & Prevent Med, Taipei, Taiwan.
   [Chen, Jen-Hau] Natl Taiwan Univ Hosp, Dept Geriatr & Gerontol, Taipei, Taiwan.
   [Chen, Yen-Ching] Natl Taiwan Univ, Coll Publ Hlth, Dept Publ Hlth, Taipei, Taiwan.
C3 Cheng Hsin General Hospital; National Yang Ming Chiao Tung University;
   Academia Sinica - Taiwan; National Taiwan University; National Taiwan
   University Hospital; National Taiwan University; National Taiwan
   University; National Taiwan University; National Taiwan University
   Hospital; National Taiwan University
RP Chen, JH; Chen, YC (corresponding author), Natl Taiwan Univ, Coll Publ Hlth, Inst Epidemiol & Prevent Med, Taipei, Taiwan.; Chen, JH (corresponding author), Natl Taiwan Univ Hosp, Dept Geriatr & Gerontol, Taipei, Taiwan.; Chen, YC (corresponding author), Natl Taiwan Univ, Coll Publ Hlth, Dept Publ Hlth, Taipei, Taiwan.
EM jhhchen@ntu.edu.tw; karenchen@ntu.edu.tw
RI Chiou, Jeng-Min/AAQ-3736-2021; Chen, Jen-Hau/AFP-2878-2022; Lai,
   Liang-Chuan/B-4768-2009; Chen, Yen-Ching/D-1098-2010
OI Chen, Ta-Fu/0000-0003-1988-6924; Lai, Liang-Chuan/0000-0002-3913-5338;
   Chen, Yen-Ching/0000-0002-8159-7202
FU Ministry of Science and Technology in Taiwan [100-2314-B-002-103,
   101-2314-B-002126-MY3, 103-2314-B-002-033-MY3, 104-2314B-002-038-MY3,
   107-2314-B-002-186-MY3]; Academia Sinica
FX Yen-Ching Chen received the funding from the Ministry of Science and
   Technology in Taiwan (100-2314-B-002-103, 101-2314-B-002126-MY3,
   103-2314-B-002-033-MY3, 104-2314B-002-038-MY3, and
   107-2314-B-002-186-MY3.) and a grant from Academia Sinica for this work.
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NR 54
TC 8
Z9 9
U1 0
U2 5
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD NOV 30
PY 2021
VL 16
IS 11
AR e0260550
DI 10.1371/journal.pone.0260550
PG 15
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Science & Technology - Other Topics
GA XW9KP
UT WOS:000735928900042
PM 34847175
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Cooper, C
   Sommerlad, A
   Lyketsos, CG
   Livingston, G
AF Cooper, Claudia
   Sommerlad, Andrew
   Lyketsos, Constantine G.
   Livingston, Gill
TI Modifiable Predictors of Dementia in Mild Cognitive Impairment: A
   Systematic Review and Meta-Analysis
SO AMERICAN JOURNAL OF PSYCHIATRY
LA English
DT Review
ID VASCULAR RISK-FACTORS; ALZHEIMERS-DISEASE; NEUROPSYCHIATRIC SYMPTOMS;
   ALCOHOL-CONSUMPTION; MEDITERRANEAN DIET; MEMORY IMPAIRMENT; ELDERLY
   SUBJECTS; PROGRESSION; CONVERSION; MCI
AB Objective: Public health campaigns encouraging early help seeking have increased rates of mild cognitive impairment (MCI) diagnosis in Western countries, but we know little about how to treat or predict dementia outcomes in persons with the condition.
   Method: The authors searched electronic databases and references for longitudinal studies reporting potentially modifiable risk factors for incident dementia after MCI. Two authors independently evaluated study quality using a checklist. Meta-analyses were conducted of three or more studies.
   Results: There were 76 eligible articles. Diabetes and prediabetes increased risk of conversion from amnestic MCI to Alzheimer's dementia; risk in treated versus untreated diabetes was lower in one study. Diabetes was also associated with increased risk of conversion from any-type or non-amnestic MCI to all-cause dementia. Metabolic syndrome and prediabetes predicted all-cause dementia in people with amnestic and any-type MCI, respectively. Mediterranean diet decreased the risk of conversion to Alzheimer's dementia. The presence of neuropsychiatric symptoms or lower serum folate levels predicted conversion from any-type MCI to all-cause dementia, but less formal education did not. Depressive symptoms predicted conversion from any-type MCI to all-cause dementia in epidemiological but not clinical studies.
   Conclusions: Diabetes increased the risk of conversion to dementia. Other prognostic factors that are potentially manageable are prediabetes and the metabolic syndrome, neuropsychiatric symptoms, and tow dietary folate. Dietary interventions and interventions to reduce neuropsychiatric symptoms, including depression, that increase risk of conversion to dementia may decrease new incidence of dementia.
C1 [Cooper, Claudia] UCL, Div Psychiat, London WC1E 6BT, England.
   Johns Hopkins Bayview Med Ctr, Dept Psychiat & Behav Sci, Baltimore, MD USA.
C3 University of London; University College London; Johns Hopkins
   University; Johns Hopkins Medicine
RP Cooper, C (corresponding author), UCL, Div Psychiat, London WC1E 6BT, England.
EM claudia.cooper@ucl.ac.uk
RI Livingston, G/C-7081-2008; Sommerlad, Andrew/Y-5517-2019; Lyketsos,
   Constantine/HJI-2492-2023; Cooper, Claudia/KHX-2436-2024; Cooper,
   Claudia/C-1556-2008
OI Cooper, Claudia/0000-0002-2777-7616; Sommerlad,
   Andrew/0000-0002-8895-7055; Livingston, Gill/0000-0001-6741-5516
FU National Institute on Aging [P50 AG-005146]; NIMH; National Institute on
   Aging; Associated Jewish Federation of Baltimore; Weinberg Foundation;
   Forest; GlaxoSmithKline; Eisai; Pfizer; AstraZeneca; Lilly;
   Ortho-McNeil; Bristol-Myers Squibb; Novartis; National Football League;
   Elan; Functional Neuromodulation
FX Dr. Lyketsos was supported by National Institute on Aging grant P50
   AG-005146 to the Johns Hopkins Alzheimer's Disease Research Center.Dr.
   Lyketsos reports receiving grant support (research or CME) from NIMH,
   the National Institute on Aging, Associated Jewish Federation of
   Baltimore, Weinberg Foundation, Forest, GlaxoSmithKline, Eisai, Pfizer,
   AstraZeneca, Lilly, Ortho-McNeil, Bristol-Myers Squibb, Novartis,
   National Football League, Elan, and Functional Neuromodulation;
   providing consultation or advice to AstraZeneca, GlaxoSmithKline, Eisai,
   Novartis, Forest, Supernus, Adlyfe, Takeda, Wyeth, Lundbeck, Merz,
   Lilly, Pfizer, Genentech, Elan, NFL Players Association, NFL Benefits
   Office, Avanir, Zinfandel, Bristol-Myers Squibb, Abvie, Janssen, Orion,
   Otsuka, Servier, and Astellas, and receiving honoraria or travel support
   from Pfizer, Forest, Glaxo-Smith Kline, and Health Monitor. The other
   authors report no financial relationships with commercial interests.
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NR 98
TC 393
Z9 432
U1 9
U2 191
PU AMER PSYCHIATRIC PUBLISHING, INC
PI WASHINGTON
PA 800 MAINE AVE SW, SUITE 900, WASHINGTON, DC 20024 USA
SN 0002-953X
EI 1535-7228
J9 AM J PSYCHIAT
JI Am. J. Psychiat.
PD APR
PY 2015
VL 172
IS 4
BP 323
EP 334
DI 10.1176/appi.ajp.2014.14070878
PG 12
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA CE8TS
UT WOS:000352117600008
PM 25698435
OA Green Submitted
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Yeboah, K
   Dodam, KK
   Affrim, PK
   Adu-Gyamfi, L
   Bado, AR
   Mensah, RNAO
   Adjei, AB
   Gyan, B
AF Yeboah, Kwame
   Dodam, Kennedy Konlan
   Affrim, Patrick Kormla
   Adu-Gyamfi, Linda
   Bado, Anormah Rashid
   Mensah, Richard N. A. Owusu
   Adjei, Afua Bontu
   Gyan, Ben
TI Metabolic syndrome and parental history of cardiovascular disease in
   young adults in urban Ghana
SO BMC PUBLIC HEALTH
LA English
DT Article
ID NUTRITION EXAMINATION SURVEY; 3RD NATIONAL-HEALTH; SUB-SAHARAN AFRICA;
   RISK-FACTORS; SYNDROME VARIABLES; CHILDHOOD; HEART; PREVALENCE;
   DEPRESSION; COMPONENTS
AB Background: Metabolic syndrome (MetS) in young adults poses significant cardiovascular diseases (CVD) risk for later years. Parental history of CVDs is known to affect the prevalence of CVD risk in adulthood. In sub-Saharan Africa, the burden of MetS in young adults and its relationship with parental CVDs is largely unknown. We studied the gender-specific prevalence of MetS and its association with parental history of diabetes, hypertension and CVDs in young adults resident in urban Ghana.
   Methods: In a cross-sectional design, 364 young adults aged 20-30 years were randomly recruited from students of University of Ghana. A structured questionnaire was used to collect data on demography, lifestyle, medical and parental medical history. Anthropometric indices and blood pressures were measured. Fasting blood samples were collected to measure plasma levels of glucose, lipid profile, urea and creatinine. MetS was defined according to the Joint Scientific Statement criteria.
   Results: The prevalence of MetS was 12.4%, higher in females than male participants (18.4% vs 5.7, p = 0.019). Female participants had higher levels of all the components of MetS than the male participants. Compared to participants with no history of parental CVDs, participants with parental CVDs had a higher proportion of abdominal obesity. A positive history of parental CVDs was associated with increase in odds of MetS [OR (95% CI): 1.23 (1.12-3.04), p = 0.037].
   Conclusion: In our study population, there is relatively high prevalence of MetS; higher in females compared to male participants. Parental history of CVDs was associated with MetS.
C1 [Yeboah, Kwame; Dodam, Kennedy Konlan; Bado, Anormah Rashid; Mensah, Richard N. A. Owusu] Univ Ghana, Sch Biomed & Allied Hlth Sci, Dept Physiol, POB 143, Korle Bu, Accra, Ghana.
   [Affrim, Patrick Kormla; Adjei, Afua Bontu] Univ Ghana, Sch Biomed & Allied Hlth Sci, Dept Chem Pathol, Accra, Ghana.
   [Adu-Gyamfi, Linda] Univ Ghana, Sch Biomed & Allied Hlth Sci, Dept Med Biochem, Accra, Ghana.
   [Gyan, Ben] Univ Ghana, Noguchi Mem Inst Med Res, Dept Immunol, Accra, Ghana.
C3 University of Ghana; University of Ghana; University of Ghana;
   University of Ghana
RP Yeboah, K (corresponding author), Univ Ghana, Sch Biomed & Allied Hlth Sci, Dept Physiol, POB 143, Korle Bu, Accra, Ghana.
EM kyeboah@ug.edu.gh
RI Yeboah, Kwame/HSF-5618-2023
OI Owusu Mensah, Richard/0000-0003-2911-6181; Yeboah,
   Kwame/0000-0001-5240-0645
FU FIC NIH HHS [D43 TW009140] Funding Source: Medline
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NR 27
TC 17
Z9 17
U1 0
U2 4
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-2458
J9 BMC PUBLIC HEALTH
JI BMC Public Health
PD AUG 3
PY 2017
VL 18
AR 96
DI 10.1186/s12889-017-4652-6
PG 8
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA FC6UN
UT WOS:000406977300005
PM 28774298
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU El Sayed, NS
   Kandil, EA
   Ghoneum, MH
AF El Sayed, Nesrine S.
   Kandil, Esraa A.
   Ghoneum, Mamdooh H.
TI Enhancement of Insulin/PI3K/Akt Signaling Pathway and Modulation of Gut
   Microbiome by Probiotics Fermentation Technology, a Kefir Grain Product,
   in Sporadic Alzheimer's Disease Model in Mice
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Article
DE metabolic syndrome; insulin signaling; alzheimer's disease; PI3/Akt
   pathway; PFT
ID GLYCATION END-PRODUCTS; TYPE-2 DIABETES-MELLITUS; INSULIN-RESISTANCE;
   OXIDATIVE STRESS; MOUSE MODEL; LONG-TERM; RECEPTOR; MEMORY; BRAIN;
   PATHOGENESIS
AB Sporadic Alzheimer's disease (AD) is the most common neurodegenerative disorder with cognitive dysfunction. Remarkably, alteration in the gut microbiome and resultant insulin resistance has been shown to be connected to metabolic syndrome, the crucial risk factor for AD, and also to be implicated in AD pathogenesis. Thus, this study, we assessed the efficiency of probiotics fermentation technology (PFT), a kefir product, in enhancing insulin signaling via modulation of gut microbiota to halt the development of AD. We also compared its effectiveness to that of pioglitazone, an insulin sensitizer that has been confirmed to substantially treat AD. AD was induced in mice by a single injection of intracerebroventricular streptozotocin (STZ; 3 mg/kg). PFT (100, 200, 400 mg/kg) and pioglitazone (30 mg/kg) were administered orally for 3 weeks. Behavioral tests were conducted to assess cognitive function, and hippocampal levels of acetylcholine (Ach) and beta-amyloid (A beta(1-42)) protein were assessed along with histological examination. Moreover, the expression of the insulin receptor, insulin degrading enzyme (IDE), and the phosphorylated forms of phosphoinositide 3-kinase (PI3K), protein kinase B (Akt), glycogen synthase kinase-3 beta (GSK-3 beta), mammalian target of rapamycin (mTOR), and tau were detected. Furthermore, oxidative stress and inflammatory biomarkers were estimated. Treatment with PFT reversed STZ-induced neurodegeneration and cognitive impairment, enhanced hippocampal Ach levels, and reduced A beta(1-42) levels after restoration of IDE activity. PFT also improved insulin signaling, as evidenced by upregulation of insulin receptor expression and activation of PI3K/Akt signaling with subsequent suppression of GSK-3 beta and mTOR signaling, which result in the downregulation of hyperphosphorylated tau. Moreover, PFT significantly diminished oxidative stress and inflammation induced by STZ. These potential effects were parallel to those produced by pioglitazone. Therefore, PFT targets multiple mechanisms incorporated in the pathogenesis of AD and hence might be a beneficial therapy for AD.
C1 [El Sayed, Nesrine S.; Kandil, Esraa A.] Cairo Univ, Dept Pharmacol & Toxicol, Cairo, Egypt.
   [Ghoneum, Mamdooh H.] Charles R Drew Univ Med & Sci, Dept Surg, 1621 E 120th St, Los Angeles, CA 90059 USA.
C3 Egyptian Knowledge Bank (EKB); Cairo University; Charles R. Drew
   University of Medicine & Science
RP El Sayed, NS (corresponding author), Cairo Univ, Dept Pharmacol & Toxicol, Cairo, Egypt.
EM nesrine_salah2002@yahoo.com
RI Sayed, Nesrine/AAX-2717-2020
FU Paitos Co., Ltd., Yokohama, Kanagawa, Japan [T0099108]
FX This study received funding from Paitos Co., Ltd., Yokohama, Kanagawa,
   Japan; Grant #T0099108. The funder was not involved in the study design,
   collection, analysis, interpretation of data, the writing of this
   article or the decision to submit it for publication.
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NR 77
TC 26
Z9 26
U1 0
U2 42
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD JUL 23
PY 2021
VL 12
AR 666502
DI 10.3389/fphar.2021.666502
PG 15
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA TV3LG
UT WOS:000681624100001
PM 34366841
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Ulla, A
   Alam, MA
   Sikder, B
   Sumi, FA
   Rahman, MM
   Habib, ZF
   Mohammed, MK
   Subhan, N
   Hossain, H
   Reza, HM
AF Ulla, Anayt
   Alam, Md Ashraful
   Sikder, Biswajit
   Sumi, Farzana Akter
   Rahman, Md Mizanur
   Habib, Zaki Farhad
   Mohammed, Mostafe Khalid
   Subhan, Nusrat
   Hossain, Hemayet
   Reza, Hasan Mahmud
TI Supplementation of Syzygium cumini seed powder prevented obesity,
   glucose intolerance, hyperlipidemia and oxidative stress in high
   carbohydrate high fat diet induced obese rats
SO BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Article
DE High carbohydrate high fat diet; Dyslipidemia; Fibrosis; Oxidative
   stress; Antioxidant
ID INSULIN-RESISTANCE; ANTIINFLAMMATORY ACTIVITY; HORMONE ADIPONECTIN;
   METABOLIC SYNDROME; WEIGHT-GAIN; EXTRACT; INFLAMMATION; DYSLIPIDEMIA;
   KERNEL; ALPHA
AB Background: Obesity and related complications have now became epidemic both in developed and developing countries. Cafeteria type diet mainly composed of high fat high carbohydrate components which plays a significant role in the development of obesity and metabolic syndrome. This study investigated the effect of Syzygium cumini seed powder on fat accumulation and dyslipidemia in high carbohydrate high fat diet (HCHF) induced obese rats.
   Method: Male Wistar rats were fed with HCHF diet ad libitum, and the rats on HCHF diet were supplemented with Syzygium cumini seed powder for 56 days (2.5% w/w of diet). Oral glucose tolerance test, lipid parameters, liver marker enzymes (AST, ALT and ALP) and lipid peroxidation products were analyzed at the end of 56 days. Moreover, antioxidant enzyme activities were also measured in all groups of rats.
   Results: Supplementation with Syzygium cumini seed powder significantly reduced body weight gain, white adipose tissue (WAT) weights, blood glucose, serum insulin, and plasma lipids such as total cholesterol, triglyceride, LDL and HDL concentration. Syzygium cumini seed powder supplementation in HCHF rats improved serum aspartate amino transferase (AST), alanine amino transferase (ALT), and alkaline phosphatase (ALP) activities. Syzygium cumini seed powder supplementation also reduced the hepatic thiobarbituric acid reactive substances (TBARS) and elevated the antioxidant enzyme superoxide dismutase (SOD) and catalase (CAT) activities as well as increased glutathione (GSH) concentration. In addition, histological assessment showed that Syzygium cumini seed powder supplementation prevented inflammatory cell infiltration; fatty droplet deposition and fibrosis in liver of HCHFD fed rats.
   Conclusion: Our investigation suggests that Syzygium cumini seed powder supplementation prevents oxidative stress and showed anti-inflammatory and antifibrotic activity in liver of HCHF diet fed rats. In addition, Syzygium cumini seed powder may be beneficial in ameliorating insulin resistance and dyslipidemia probably by increasing lipid metabolism in liver of HCHF diet fed rats.
C1 [Ulla, Anayt; Alam, Md Ashraful; Sikder, Biswajit; Sumi, Farzana Akter; Rahman, Md Mizanur; Habib, Zaki Farhad; Mohammed, Mostafe Khalid; Subhan, Nusrat; Reza, Hasan Mahmud] North South Univ, Dept Pharmaceut Sci, Dhaka 1229, Bangladesh.
   [Hossain, Hemayet] Bangladesh Council Sci & Ind Res, BCSIR Labs, Dhaka, Bangladesh.
C3 North South University (NSU); Bangladesh Council of Scientific &
   Industrial Research (BCSIR); BCSIR Laboratories Dhaka
RP Alam, MA; Reza, HM (corresponding author), North South Univ, Dept Pharmaceut Sci, Dhaka 1229, Bangladesh.
EM sonaliagun@yahoo.com; hasan.reza@northsouth.edu
RI Ulla, Anayt/AGJ-3338-2022; Alam, Ashraful/G-1964-2014; hossain,
   hemayet/O-5996-2018; Rahman, Md Mizanur/AAC-7666-2019; Reza, Hasan
   Mahmud/AFL-0151-2022
OI Rahman, Md Mizanur/0000-0002-7178-7977; Reza, Hasan
   Mahmud/0000-0003-3287-942X; Hossain, Hemayet/0000-0001-8759-9279; Ulla,
   Anayt/0000-0002-1733-5734; Alam, Md Ashraful/0000-0001-7596-5868
FU Ministry of Science and Technology, Bangladesh [2015-1016]
FX This research was partially supported by Research Grant (Special
   allocation grant), 2015-1016 to Dr. Hasan Mahmud Reza and Dr. Md
   Ashraful Alam, from Ministry of Science and Technology, Bangladesh.
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NR 53
TC 64
Z9 66
U1 0
U2 10
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1472-6882
J9 BMC COMPLEM ALTERN M
JI BMC Complement. Altern. Med.
PD JUN 2
PY 2017
VL 17
AR 289
DI 10.1186/s12906-017-1799-8
PG 13
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA EW6CX
UT WOS:000402594300003
PM 28578702
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Lane, MM
   Davis, JA
   Beattie, S
   Gómez-Donoso, C
   Loughman, A
   O'Neil, A
   Jacka, F
   Berk, M
   Page, R
   Marx, W
   Rocks, T
AF Lane, Melissa M.
   Davis, Jessica A.
   Beattie, Sally
   Gomez-Donoso, Clara
   Loughman, Amy
   O'Neil, Adrienne
   Jacka, Felice
   Berk, Michael
   Page, Richard
   Marx, Wolfgang
   Rocks, Tetyana
TI Ultraprocessed food and chronic noncommunicable diseases: A systematic
   review and meta-analysis of 43 observational studies
SO OBESITY REVIEWS
LA English
DT Review
DE meta&#8208; analysis; noncommunicable disease; NOVA; ultraprocessed food
ID ULTRA-PROCESSED FOODS; ALL-CAUSE MORTALITY; GUT MICROBIOTA; SEGUIMIENTO
   UNIVERSIDAD; MEDITERRANEAN COHORT; NUTRIENT PROFILE; NATIONAL-HEALTH;
   DIETARY FIBER; CONSUMPTION; OBESITY
AB This systematic review and meta-analysis investigated the association between consumption of ultraprocessed food and noncommunicable disease risk, morbidity and mortality. Forty-three observational studies were included (N = 891,723): 21 cross-sectional, 19 prospective, two case-control and one conducted both a prospective and cross-sectional analysis. Meta-analysis demonstrated consumption of ultraprocessed food was associated with increased risk of overweight (odds ratio: 1.36; 95% confidence interval [CI], 1.23-1.51; P < 0.001), obesity (odds ratio: 1.51; 95% CI, 1.34-1.70; P < 0.001), abdominal obesity (odds ratio: 1.49; 95% CI, 1.34-1.66; P < 0.0001), all-cause mortality (hazard ratio: 1.28; 95% CI, 1.11-1.48; P = 0.001), metabolic syndrome (odds ratio: 1.81; 95% CI, 1.12-2.93; P = 0.015) and depression in adults (hazard ratio: 1.22; 95% CI, 1.16-1.28, P < 0.001) as well as wheezing (odds ratio: 1.40; 95% CI, 1.27-1.55; P < 0.001) but not asthma in adolescents (odds ratio: 1.20; 95% CI, 0.99-1.46; P = 0.065). In addition, consumption of ultraprocessed food was associated with cardiometabolic diseases, frailty, irritable bowel syndrome, functional dyspepsia and cancer (breast and overall) in adults while also being associated with metabolic syndrome in adolescents and dyslipidaemia in children. Although links between ultraprocessed food consumption and some intermediate risk factors in adults were also highlighted, further studies are required to more clearly define associations in children and adolescents.
   Study registration Prospero ID: CRD42020176752.
C1 [Lane, Melissa M.; Davis, Jessica A.; Loughman, Amy; O'Neil, Adrienne; Jacka, Felice; Berk, Michael; Page, Richard; Marx, Wolfgang; Rocks, Tetyana] Deakin Univ, Inst Mental & Phys Hlth & Clin Translat IMPACT, Food & Mood Ctr, Sch Med,Barwon Hlth, Geelong, Vic, Australia.
   [Gomez-Donoso, Clara] Univ Navarra, Sch Med, Dept Prevent Med & Publ Hlth, Pamplona, Spain.
   [Gomez-Donoso, Clara] Carlos III Hlth Inst, CIBER Physiopathol Obes & Nutr CIBEROBN, Madrid, Spain.
   [Beattie, Sally; Page, Richard] Barwon Hlth, Barwon Ctr Orthopaed Res & Educ B CORE, Geelong, Vic, Australia.
   [Beattie, Sally; Page, Richard] St John God Hosp Geelong, Geelong, Vic, Australia.
   [Page, Richard] Deakin Univ, Sch Med, Geelong, Vic, Australia.
   [Jacka, Felice] Murdoch Childrens Res Inst, Ctr Adolescent Hlth, Melbourne, Vic, Australia.
   [Jacka, Felice] Black Dog Inst, Randwick, NSW, Australia.
   [Jacka, Felice] James Cook Univ, Coll Publ Hlth Med & Vet Sci, Townsville, Qld, Australia.
   [Berk, Michael] Univ Melbourne, Orygen Natl Ctr Excellence Youth Mental Hlth, Ctr Youth Mental Hlth, Florey Inst Neurosci & Mental Hlth, Melbourne, Vic, Australia.
   [Berk, Michael] Univ Melbourne, Dept Psychiat, Melbourne, Vic, Australia.
C3 Deakin University; Barwon Health; University of Navarra; CIBER - Centro
   de Investigacion Biomedica en Red; CIBEROBN; Barwon Health; St John of
   God Health Care; Deakin University; Murdoch Children's Research
   Institute; Black Dog Institute; James Cook University; University of
   Melbourne; Orygen, The National Centre of Excellence in Youth Mental
   Health; Florey Institute of Neuroscience & Mental Health; University of
   Melbourne
RP Lane, MM (corresponding author), Deakin Univ, Inst Mental & Phys Hlth & Clin Translat IMPACT, Food & Mood Ctr, Sch Med,Barwon Hlth, Geelong, Vic, Australia.
EM laneme@deakin.edu.au
RI Gómez Donoso, Clara/AAC-6190-2019; Marx, Wolfgang/AFO-7355-2022; Jacka,
   Felice/ABE-6322-2020; Berk, Michael/AGH-9427-2022; Loughman,
   Amy/J-9295-2018; Page, Richard/K-6327-2015; Berk, Michael/M-7891-2013
OI Marx, Wolfgang/0000-0002-8556-8230; Lane, Melissa/0000-0002-5739-4560;
   Gomez Donoso, Clara/0000-0003-4753-3560; O'Neil,
   Adrienne/0000-0002-4811-5830; Loughman, Amy/0000-0002-0257-1443; Davis,
   Jessica/0000-0001-7246-4291; Page, Richard/0000-0002-2225-7144; Berk,
   Michael/0000-0002-5554-6946
FU Princess Alexandra Research Foundation; Cobram Estate Pty. Ltd; La Trobe
   University; Cancer Council Queensland; Multiple Sclerosis Research
   Australia; Alfred Deakin Postdoctoral Research Fellowship; Global Age;
   City of Greater Geelong; Parkdale College; Central West Gippsland
   Primary Care Partnership; West Gippsland Healthcare Group; Barwon
   Health; Primary Health Networks; Department of Health and Human
   Services; Australian Disease Management Association; Black Dog
   Institute; Academy of Nutrition and Dietetics; Royal Australian and New
   Zealand College of Psychiatrists; Nutrition Society of Australia;
   Dietitians Association of Australia; University of Southern Queensland;
   Bond University; Oxford University Press; Australian Postgraduate
   Awards; University of the Sunshine Coast; Harry Windsor Foundation;
   Avant; Beyond Blue; Medical Research Futures Fund; Medical Benefits
   Fund; Stanley Medical Research Foundation; Cancer Council of Victoria;
   Simons Autism Foundation; Cooperative Research Centre; Senior Principal
   Research Fellowship [1156072, 1059660]; Metagenics; Angelini
   Farmaceutica; Network Nutrition; Pfizer; Servier; Janssen Cilag;
   Sanofi-Synthelabo; Eli Lilly Australia; Ian Potter Foundation; Geelong
   Medical Research Foundation; Australian Rotary Health; Brain and
   Behaviour Research Institute; Novartis; Woolworths Limited; Meat and
   Livestock Australia; Sanofi; Australian Research Council; Wilson
   Foundation; Heart Foundation Australia [101160]; Fonds de la Recherche
   Scientifique (FNRS); Falk Foundation; Australian and New Zealand College
   of Anaesthetists; European Society of Neurogastroenterology;
   International Human Microbiome Congress; Epilepsy Society of Australia;
   American Epilepsy Society; University of Technology Sydney; Sydney
   University; Jack Brockhoff Foundation; National Institutes of Health
   (NIH); Australian Academy of Science; National Health and Medical
   Research Council (NHMRC); Deakin University; RMIT University; University
   of Melbourne; University of New South Wales; Carlos III Health Institute
   [FI18/00073]; Australian Government Research Training Program
   Scholarship; Deakin University Scholarship; Be Fit Foods; A2 Milk
   Company; Fernwood Foundation
FX Princess Alexandra Research Foundation; Cobram Estate Pty. Ltd; La Trobe
   University; Cancer Council Queensland; Multiple Sclerosis Research
   Australia; Alfred Deakin Postdoctoral Research Fellowship; Global Age;
   City of Greater Geelong; Parkdale College; Central West Gippsland
   Primary Care Partnership; West Gippsland Healthcare Group; Barwon
   Health; Primary Health Networks; Department of Health and Human
   Services; Australian Disease Management Association; Black Dog
   Institute; Academy of Nutrition and Dietetics; The Royal Australian and
   New Zealand College of Psychiatrists; Nutrition Society of Australia;
   Dietitians Association of Australia; University of Southern Queensland;
   Bond University; Oxford University Press; Australian Postgraduate
   Awards; University of the Sunshine Coast; Harry Windsor Foundation;
   Avant; Beyond Blue; Medical Research Futures Fund; Medical Benefits
   Fund; Stanley Medical Research Foundation; Cancer Council of Victoria;
   Simons Autism Foundation; Cooperative Research Centre; Senior Principal
   Research Fellowship, Grant/Award Numbers: 1156072, 1059660; Metagenics;
   Angelini Farmaceutica; Network Nutrition; Pfizer; Servier; Janssen
   Cilag; Sanofi-Synthelabo; Eli Lilly Australia; Ian Potter Foundation;
   Geelong Medical Research Foundation; Australian Rotary Health; Brain and
   Behaviour Research Institute; Novartis; Woolworths Limited; Meat and
   Livestock Australia; Sanofi; Australian Research Council; Wilson
   Foundation; Heart Foundation Australia, Grant/Award Number: (#101160;
   Fonds de la Recherche Scientifique (FNRS); Falk Foundation; Australian
   and New Zealand College of Anaesthetists; European Society of
   Neurogastroenterology; International Human Microbiome Congress; Epilepsy
   Society of Australia; American Epilepsy Society; University of
   Technology Sydney; Sydney University; The Jack Brockhoff Foundation;
   National Institutes of Health (NIH); Australian Academy of Science;
   National Health and Medical Research Council (NHMRC); Deakin University;
   RMIT University; University of Melbourne; University of New South Wales;
   Carlos III Health Institute, Grant/Award Number: FI18/00073; Australian
   Government Research Training Program Scholarship; Deakin University
   Scholarship; Be Fit Foods; A2 Milk Company; Wilson Foundation; Fernwood
   Foundation
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   Zinöcker MK, 2018, NUTRIENTS, V10, DOI 10.3390/nu10030365
NR 122
TC 410
Z9 419
U1 11
U2 147
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1467-7881
EI 1467-789X
J9 OBES REV
JI Obes. Rev.
PD MAR
PY 2021
VL 22
IS 3
DI 10.1111/obr.13146
EA NOV 2020
PG 19
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism
GA QG6GI
UT WOS:000587582100001
PM 33167080
OA Bronze, Green Published
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Ji, MH
   Ren, DX
   Gary-Webb, TL
   Dunbar-Jacob, J
   Erlen, JA
AF Ji, Meihua
   Ren, Dianxu
   Gary-Webb, Tiffany L.
   Dunbar-Jacob, Jacqueline
   Erlen, Judith A.
TI Characterizing a Sample of Chinese Patients With Type 2 Diabetes and
   Selected Health Outcomes
SO DIABETES EDUCATOR
LA English
DT Article
ID SELF-CARE ACTIVITIES; GLYCEMIC CONTROL; METABOLIC SYNDROME; MANAGEMENT;
   ADULTS; POPULATION; DEPRESSION; PREVALENCE; EFFICACY; LITERACY
AB Purpose The purpose of the study is to describe the characteristics and selected health outcomes of a sample of Chinese patients with type 2 diabetes (T2DM) and to examine gender differences based on social cognitive theory. There is limited study in theory-driven research conducted in China and a lack of evidence in collectively examining the associated factors among Chinese patients with T2DM based on a theory, especially among those living in a suburban area. Methods Following a cross-sectional design, data were collected from 207 patients (50.2% women; mean age, 56.1 years) with T2DM from an outpatient clinic in a suburban area of Beijing, China. Participants completed a survey, and clinical values were retrieved from the patients' medical records. Results Of the participants, more than half had suboptimal glycemic control; only a small proportion had recommended levels in performing self-management behaviors. A large proportion had metabolic syndrome and were overweight or obese. Compared with men, women demonstrated poorer health literacy and problem solving, received less social support, and presented with more depressive symptoms. Conclusion Glycemic control and self-management were suboptimal in this sample, and a large proportion of the sample was at risk of developing cardiovascular disease. Gender differences exist regarding health literacy, depressive symptoms, problem solving, and social support. Social cognitive theory may provide a lens for addressing factors that are important in improving health outcomes among Chinese patients with T2DM. This evidence will help health care providers to identify pertinent factors through a multifactorial approach, therefore providing tailored care for Chinese patients with T2DM.
C1 [Ji, Meihua; Erlen, Judith A.] Univ Pittsburgh, Sch Nursing, Dept Hlth & Community Syst, 3500 Victoria St,Victoria Bldg, Pittsburgh, PA 15261 USA.
   [Ren, Dianxu] Univ Pittsburgh, Sch Nursing, Ctr Res & Evaluat & Hlth & Community Syst, Pittsburgh, PA 15261 USA.
   [Gary-Webb, Tiffany L.] Univ Pittsburgh, Grad Sch Publ Hlth, Behav & Community Hlth Sci & Epidemiol, Pittsburgh, PA USA.
   [Dunbar-Jacob, Jacqueline] Univ Pittsburgh, Sch Nursing, Pittsburgh, PA 15261 USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE); University
   of Pittsburgh; Pennsylvania Commonwealth System of Higher Education
   (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of
   Higher Education (PCSHE); University of Pittsburgh; Pennsylvania
   Commonwealth System of Higher Education (PCSHE); University of
   Pittsburgh
RP Ji, MH (corresponding author), Univ Pittsburgh, Sch Nursing, Dept Hlth & Community Syst, 3500 Victoria St,Victoria Bldg, Pittsburgh, PA 15261 USA.
EM mej61@pitt.edu
OI Gary-Webb, Tiffany/0000-0001-9843-1084
FU Margaret E. Wilkes Scholarship Fund Award, School of Nursing, University
   of Pittsburgh [FY18]
FX This study was supported by the Margaret E. Wilkes Scholarship Fund
   Award (FY18), School of Nursing, University of Pittsburgh.
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NR 46
TC 14
Z9 14
U1 0
U2 6
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0145-7217
EI 1554-6063
J9 DIABETES EDUCATOR
JI Diabetes Educ.
PD FEB
PY 2019
VL 45
IS 1
BP 105
EP 115
DI 10.1177/0145721718811561
PG 11
WC Endocrinology & Metabolism; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Public, Environmental & Occupational Health
GA HI4RG
UT WOS:000456437600010
PM 30403150
DA 2025-06-11
ER

PT J
AU Muldoon, MF
   Mackey, RH
   Sutton-Tyrrell, K
   Flory, JD
   Pollock, BG
   Manuck, SB
AF Muldoon, Matthew F.
   Mackey, Rachel H.
   Sutton-Tyrrell, Kim
   Flory, Janine D.
   Pollock, Bruce G.
   Manuck, Stephen B.
TI Lower central serotonergic responsivity is associated with preclinical
   carotid artery atherosclerosis
SO STROKE
LA English
DT Article
DE atherosclerosis; central nervous system; serotonin
ID TRANSPORTER GENE POLYMORPHISM; DEPENDENT DIABETES-MELLITUS; METABOLIC
   SYNDROME; FENFLURAMINE CHALLENGE; DEPRESSIVE SYMPTOMS; PROLACTIN
   SECRETION; INSULIN-RESISTANCE; MAJOR DEPRESSION; 5-HT2A RECEPTOR;
   OBESE-PATIENTS
AB Background and Purpose - Central nervous system serotonergic neurotransmission appears to play a role in mood disorders, eating habits, and sleep, and also modulates blood pressure and metabolism. This investigation tested a hypothesized association between central serotonergic functioning and preclinical atherosclerosis.
   Methods - Subjects were 244 adults 30 to 55 years of age and free of clinically evident vascular disease (52% men, 84% white). Central serotonergic responsivity was measured as the rise in serum prolactin concentration (area under the curve) over 2.5 hours, adjusted for baseline prolactin, after citalopram administered intravenously at 0.33 mg/kg lean body weight. Carotid artery morphology served as a marker of preclinical atherosclerosis, and carotid artery intima-media thickness and plaque occurrence were determined by B-mode ultrasonography.
   Results - In linear regression models including age, gender, race, and citalopram concentration, a 1 SD lower prolactin response was associated with greater maximum intima-media thickness (+0.016 mm; P=0.006) and with greater mean intima-media thickness (+0.009 mm; P=0.03). The odds ratio for carotid artery plaque corresponding to a 1 SD decrease in prolactin response, adjusted for age, race, sex, and citalopram concentration, was 1.47 (95% CI, 0.98 to 2.19; P=0.06). The metabolic syndrome mediated (P=0.01), but did not fully account for, the association between lower prolactin response and greater maximum intima-media thickness.
   Conclusions - In this young and relatively healthy sample, blunted prolactin response to citalopram was associated with carotid artery thickening, suggesting that individual differences in central serotonergic responsivity are inversely related to preclinical vascular disease.
C1 Univ Pittsburgh, Behav Physiol Lab, Dept Psychol, Pittsburgh, PA 15260 USA.
   Univ Pittsburgh, Ctr Clin Pharmacol, Pittsburgh, PA 15260 USA.
   Univ Pittsburgh, Dept Med, Dept Epidemiol, Grad Sch Publ Hlth, Pittsburgh, PA 15260 USA.
   Mt Sinai Sch Med, Dept Psychiat, New York, NY USA.
   Univ Toronto, Rotman Res Inst, Toronto, ON, Canada.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE); University
   of Pittsburgh; Pennsylvania Commonwealth System of Higher Education
   (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of
   Higher Education (PCSHE); University of Pittsburgh; Icahn School of
   Medicine at Mount Sinai; University of Toronto; Baycrest
RP Muldoon, MF (corresponding author), Univ Pittsburgh, Behav Physiol Lab, Dept Psychol, 506 OEH,4015 O Hara St, Pittsburgh, PA 15260 USA.
EM mfm10@pitt.edu
OI Mackey, Rachel/0000-0001-6088-2664
FU NCRR NIH HHS [MO1 RR00056] Funding Source: Medline; NHLBI NIH HHS [P01
   HL 40962] Funding Source: Medline; NIMH NIH HHS [K24 MH065416] Funding
   Source: Medline
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NR 55
TC 36
Z9 37
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0039-2499
EI 1524-4628
J9 STROKE
JI Stroke
PD AUG
PY 2007
VL 38
IS 8
BP 2228
EP 2233
DI 10.1161/STROKEAHA.106.477638
PG 6
WC Clinical Neurology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Cardiovascular System & Cardiology
GA 196AY
UT WOS:000248455100008
PM 17626900
DA 2025-06-11
ER

PT J
AU Federico, A
   Dallio, M
   Masarone, M
   Gravina, AG
   Di Sarno, R
   Tuccillo, C
   Cossiga, V
   Lama, S
   Stiuso, P
   Morisco, F
   Persico, M
   Loguercio, C
AF Federico, Alessandro
   Dallio, Marcello
   Masarone, Mario
   Gravina, Antonietta Gerarda
   Di Sarno, Rosa
   Tuccillo, Concetta
   Cossiga, Valentina
   Lama, Stefania
   Stiuso, Paola
   Morisco, Filomena
   Persico, Marcello
   Loguercio, Carmelina
TI Evaluation of the Effect Derived from Silybin with Vitamin D and Vitamin
   E Administration on Clinical, Metabolic, Endothelial Dysfunction,
   Oxidative Stress Parameters, and Serological Worsening Markers in
   Nonalcoholic Fatty Liver Disease Patients
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Article
ID CONTROLLED ATTENUATION PARAMETER; CARDIOVASCULAR-DISEASE; FIBROSIS;
   NAFLD; RISK; NASH
AB Nowadays, the nonalcoholic fatty liver disease represents the main chronic liver disease in the Western countries, and the correct medical therapy remains a big question for the scientific community. The aim of our study was to evaluate the effect derived from the administration for six months of silybin with vitamin D and vitamin E (RealSIL 100D (R)) on metabolic markers, oxidative stress, endothelial dysfunction, and worsening of disease markers in nonalcoholic fatty liver disease patients. We enrolled 90 consecutive patients with histological diagnosis of nonalcoholic fatty liver disease and 60 patients with diagnosis of reflux disease (not in therapy) as healthy controls. The nonalcoholic fatty liver disease patients were randomized into two groups: treated (60 patients) and not treated (30 patients). We performed a nutritional assessment and evaluated clinical parameters, routine home tests, the homeostatic model assessment of insulin resistance, NAFLD fibrosis score and fibrosis-4, transient elastography and controlled attenuation parameter, thiobarbituric acid reactive substances, tumor necrosis factor alpha, transforming growth factor beta, interleukin-18 and interleukin-22, matrix metalloproteinase 2, epidermal growth factor receptor, insulin growth factor-II, cluster of differentiation-44, high mobility group box-1, and Endocan. Compared to the healthy controls, the nonalcoholic fatty liver disease patients had statistically significant differences for almost all parameters evaluated at baseline (p < 0.05). Six months after the baseline, the proportion of nonalcoholic fatty liver disease patients treated that underwent a statistically significant improvement in metabolic markers, oxidative stress, endothelial dysfunction, and worsening of disease was greater than not treated nonalcoholic fatty liver disease patients (p < 0.05). Even more relevant results were obtained for the same parameters by analyzing patients with a concomitant diagnosis of metabolic syndrome (p < 0.001). The benefit that derives from the use of RealSIL 100D could derive from the action on more systems able to advance the pathology above all in that subset of patients suffering from concomitant metabolic syndrome.
C1 [Federico, Alessandro; Dallio, Marcello; Gravina, Antonietta Gerarda; Di Sarno, Rosa; Tuccillo, Concetta; Lama, Stefania; Stiuso, Paola; Loguercio, Carmelina] Univ Campania Luigi Vanvitelli, Dept Precis Med, Via Crecchio 7, I-80138 Naples, Italy.
   [Masarone, Mario; Persico, Marcello] Univ Salerno, Dept Med & Surg, Scuola Med Salernitana, Internal Med & Hepatol Unit, Via Allende, I-84081 Salerno, Italy.
   [Cossiga, Valentina; Morisco, Filomena] Univ Naples Federico II, Dept Clin Med & Surg, Naples, Italy.
C3 Universita della Campania Vanvitelli; University of Salerno; University
   of Naples Federico II
RP Dallio, M (corresponding author), Univ Campania Luigi Vanvitelli, Dept Precis Med, Via Crecchio 7, I-80138 Naples, Italy.
EM marcello.dallio@gmail.com
RI Dallio, Marcello/ABG-7693-2020; Federico, Alessandro/AAB-3893-2019;
   Morisco, Filomena/AHI-0851-2022; Cossiga, Valentina/ABB-3331-2021;
   persico, marcello/AAB-3562-2019; Gravina, Antonietta
   Gerarda/AAC-1528-2019; Masarone, Mario/H-8633-2017
OI Morisco, Filomena/0009-0006-1537-5034; Persico,
   Marcello/0000-0002-1399-6498; Masarone, Mario/0000-0003-0550-8201;
   Cossiga, Valentina/0000-0002-0000-1076; Gravina, Antonietta
   Gerarda/0000-0001-8049-0115; DALLIO, MARCELLO/0000-0003-4153-815X;
   Federico, Alessandro/0000-0002-0885-0793; morisco,
   filomena/0000-0002-9059-8311
FU Valere Program
FX Research activity of Dr. Antonietta G. Gravina was supported by the
   Valere Program.
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NR 53
TC 53
Z9 53
U1 1
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PD OCT 15
PY 2019
VL 2019
AR 8742075
DI 10.1155/2019/8742075
PG 12
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA JH8EU
UT WOS:000493002300003
PM 31737175
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Algotar, AM
   Kumar, R
   Babiker, HM
   Dougherty, ST
   Hsu, CH
   Chow, HH
   Smith, TE
   Marrero, DG
   Courneya, KS
   Abraham, 
   Ligibel, JA
   Thomson, CA
AF Algotar, A. M.
   Kumar, R.
   Babiker, H. M.
   Dougherty, S. T.
   Hsu, C. H.
   Chow, H-H
   Smith, T. E.
   Marrero, D. G.
   Courneya, K. S.
   Abraham, I
   Ligibel, J. A.
   Thomson, C. A.
TI Protocol for a feasibility and early efficacy study of the Comprehensive
   Lifestyle Improvement Program for Prostate Cancer-2 (CLIPP2)
SO CONTEMPORARY CLINICAL TRIALS COMMUNICATIONS
LA English
DT Article
DE Lifestyle Modification; Androgen Deprivation Therapy; Prostate Cancer
ID ANDROGEN-DEPRIVATION THERAPY; QUALITY-OF-LIFE; MEN
AB Background: Although androgen deprivation therapy (ADT) for prostate cancer demonstrates improved overall and disease-free survival, it is associated with adverse effects such as obesity and metabolic syndrome that increase risk of cardiometabolic disease and diabetes type 2. ADT also leads to fatigue, depression and erectile dysfunction, which reduce quality of life (QoL). Lifestyle modification has shown promise in reducing obesity, metabolic syndrome and diabetes type 2 in other disease types. However, there is a paucity of data regarding the utility of lifestyle modification in men receiving ADT for prostate cancer.
   Methods: The primary aim of the Comprehensive Lifestyle Improvement Program for Prostate Cancer-2 (CLIPP2) is to test the feasibility of conducting a 24-week lifestyle modification intervention in men on ADT for prostate cancer. Additionally, it will also determine the effect of this intervention on weight loss, cardiometabolic markers (secondary aim and markers of interest: serum glucose, insulin resistance, hemoglobin A1C and lipid panel), and QoL (tertiary aim). The intervention will be delivered weekly via telephone for the first 10 weeks and biweekly for the remaining 14 weeks. Questionnaires and serum samples will be collected at baseline, week 12, and week 24. Anthropometric measurements will be collected at baseline, week 6, week 12, week 18 and week 24.
   Results: We hypothesize that the CLIPP2 intervention will produce a 7% weight loss that will result in improved markers associated with cardiometabolic disease and type 2 diabetes in the study population.
   Conclusion: Results will provide insight into the role of lifestyle modification in addressing ADT adverse effects as well as provide preliminary data to inform the development of future lifestyle interventions in this area.
C1 [Algotar, A. M.; Smith, T. E.; Abraham, I] Univ Arizona, Dept Family & Community Med, 655 N Alvernon Way,STE 228, Tucson, AZ 85711 USA.
   [Algotar, A. M.; Babiker, H. M.; Dougherty, S. T.; Hsu, C. H.; Chow, H-H; Thomson, C. A.] Univ Arizona, Canc Ctr, Tucson, AZ 85711 USA.
   [Kumar, R.] Banner MD Anderson Canc Ctr, Radiat Oncol, Gilbert, AZ USA.
   [Babiker, H. M.] Univ Arizona, Dept Hematol Oncol, Tucson, AZ 85711 USA.
   [Dougherty, S. T.] Univ Arizona, Dept Radiat Oncol, Tucson, AZ 85711 USA.
   [Hsu, C. H.] Univ Arizona, Dept Epidemiol & Biostat, Mel & Enid Coll Publ, Tucson, AZ 85711 USA.
   [Marrero, D. G.; Thomson, C. A.] Univ Arizona, Dept Hlth Promot Sci, Mel & Enid Coll Publ, Tucson, AZ 85711 USA.
   [Courneya, K. S.] Univ Alberta, Fac Kinesiol Sport & Recreat, Edmonton, AB, Canada.
   [Abraham, I] Univ Arizona, Coll Pharm, Tucson, AZ 85711 USA.
   [Ligibel, J. A.] Harvard Med Sch, Dana Farber Canc Inst, Boston, MA 02115 USA.
C3 University of Arizona; University of Arizona; Banner Research; Banner
   Health; Banner MD Anderson Cancer Center; University of Texas System;
   UTMD Anderson Cancer Center; University of Arizona; University of
   Arizona; University of Arizona; University of Arizona; University of
   Alberta; University of Arizona; Harvard University; Harvard University
   Medical Affiliates; Dana-Farber Cancer Institute; Harvard Medical School
RP Algotar, AM (corresponding author), Univ Arizona, Dept Family & Community Med, 655 N Alvernon Way,STE 228, Tucson, AZ 85711 USA.
EM algotar@email.arizona.edu
RI Courneya, Kerry/AAJ-2712-2021
FU Departmental funds (Department of Family and Community Medicine
   University of Arizona); Banner MD Anderson Cancer Center
FX Departmental funds (Department of Family and Community Medicine
   University of Arizona), Institutional funding (Banner MD Anderson Cancer
   Center) and Private donor funds.
CR Bosco C, 2015, EUR UROL, V68, P386, DOI 10.1016/j.eururo.2014.11.039
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NR 19
TC 1
Z9 1
U1 0
U2 2
PU ELSEVIER INC
PI SAN DIEGO
PA 525 B STREET, STE 1900, SAN DIEGO, CA 92101-4495 USA
EI 2451-8654
J9 CONT CLIN TRIAL COMM
JI Contemp. Clin. Trials Commun.
PD MAR
PY 2021
VL 21
AR 100701
DI 10.1016/j.conctc.2021.100701
EA JAN 2021
PG 5
WC Medicine, Research & Experimental
WE Emerging Sources Citation Index (ESCI)
SC Research & Experimental Medicine
GA RH5RT
UT WOS:000636276300006
PM 33511299
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Osman, A
   El-Gamal, H
   Pasha, M
   Zeidan, A
   Korashy, HM
   Abdelsalam, SS
   Hasan, M
   Benameur, T
   Agouni, A
AF Osman, Aisha
   El-Gamal, Heba
   Pasha, Mazhar
   Zeidan, Asad
   Korashy, Hesham M.
   Abdelsalam, Shahenda S.
   Hasan, Maram
   Benameur, Tarek
   Agouni, Abdelali
TI Endoplasmic Reticulum (ER) Stress-Generated Extracellular Vesicles
   (Microparticles) Self-Perpetuate ER Stress and Mediate Endothelial Cell
   Dysfunction Independently of Cell Survival
SO FRONTIERS IN CARDIOVASCULAR MEDICINE
LA English
DT Article
DE extracellular vesicles (EVs); microparticles (MPs); endothelial function
   (dysfunction); apoptosis; cardiovascular disease; ER stress
ID CIRCULATING MICROPARTICLES; PROGENITOR CELLS; DIABETIC-RATS; INHIBITION;
   ACTIVATION; PLATELET; EXOSOMES; DEATH; OXIDE
AB Circulating extracellular vesicles (EVs) are recognized as biomarkers and effectors of endothelial dysfunction, the initiating step of cardiovascular abnormalities. Among these EVs, microparticles (MPs) are vesicles directly released from the cytoplasmic membrane of activated cells. MPs were shown to induce endothelial dysfunction through the activation of endoplasmic reticulum (ER) stress. However, it is not known whether ER stress can lead to MPs release from endothelial cells and what biological messages are carried by these MPs. Therefore, we aimed to assess the impact of ER stress on MPs shedding from endothelial cells, and to investigate their effects on endothelial cell function. EA.hy926 endothelial cells or human umbilical vein endothelial cells (HUVECs) were treated for 24 h with ER stress inducers, thapsigargin or dithiothreitol (DTT), in the presence or absence of 4-Phenylbutyric acid (PBA), a chemical chaperone to inhibit ER stress. Then, MPs were isolated and used to treat cells (10-20 mu g/mL) for 24-48 h before assessing ER stress response, angiogenic capacity, nitric oxide (NO) release, autophagy and apoptosis. ER stress (thapsigargin or DDT)-generated MPs did not differ quantitatively from controls; however, they carried deleterious messages for endothelial function. Exposure of endothelial cells to ER stress-generated MPs increased mRNA and protein expression of key ER stress markers, indicating a vicious circle activation of ER stress. ER stress (thapsigargin)-generated MPs impaired the angiogenic capacity of HUVECs and reduced NO release, indicating an impaired endothelial function. While ER stress (thapsigargin)-generated MPs altered the release of inflammatory cytokines, they did not, however, affect autophagy or apoptosis in HUVECs. This work enhances the general understanding of the deleterious effects carried out by MPs in medical conditions where ER stress is sustainably activated such as diabetes and metabolic syndrome.
C1 [Osman, Aisha; El-Gamal, Heba; Pasha, Mazhar; Korashy, Hesham M.; Abdelsalam, Shahenda S.; Hasan, Maram; Agouni, Abdelali] Qatar Univ, Coll Pharm, QU Hlth, Dept Pharmaceut Sci, Doha, Qatar.
   [Zeidan, Asad] Qatar Univ, Dept Basic Sci, Coll Med, QU Hlth, Doha, Qatar.
   [Benameur, Tarek] King Faisal Univ, Coll Med, Al Hasa, Saudi Arabia.
C3 Qatar University; Qatar University; King Faisal University
RP Agouni, A (corresponding author), Qatar Univ, Coll Pharm, QU Hlth, Dept Pharmaceut Sci, Doha, Qatar.
EM aagouni@qu.edu.qa
RI Korashy, Hesham/A-1059-2010; Agouni, Abdelali/AAP-5298-2020; BENAMEUR,
   T/KIH-8629-2024
OI Agouni, Abdelali/0000-0002-8363-1582; Hasan, Maram/0000-0003-2917-3653;
   Korashy, Hesham M./0000-0002-5745-9643
FU Qatar University [QUCG-CPH-20/21-3, IRCC-2019-006, QUST-2-CPH-2017-19,
   QUST-1-CPH-2018-1]; Qatar National Research Fund (Qatar Foundation)
   [UREP24-016-3-004]; office of graduate studies (Qatar University)
FX This research was made possible by Qatar University grants
   (QUCG-CPH-20/21-3; IRCC-2019-006; QUST-2-CPH-2017-19; QUST-1-CPH-2018-1)
   and award UREP24-016-3-004 from Qatar National Research Fund (a member
   of Qatar Foundation). SA is supported by a graduate assistantship from
   the office of graduate studies (Qatar University). The findings achieved
   and statements made herein are solely the responsibility of the authors.
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NR 36
TC 20
Z9 20
U1 0
U2 3
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2297-055X
J9 FRONT CARDIOVASC MED
JI Front. Cardiovasc. Med.
PD DEC 10
PY 2020
VL 7
AR 584791
DI 10.3389/fcvm.2020.584791
PG 15
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA PI7IH
UT WOS:000601259700001
PM 33363219
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Asboe, D
   Catalan, J
   Mandalia, S
   Dedes, N
   Florence, E
   Schrooten, W
   Noestlinger, C
   Colebunders, R
AF Asboe, D.
   Catalan, J.
   Mandalia, S.
   Dedes, N.
   Florence, E.
   Schrooten, W.
   Noestlinger, C.
   Colebunders, R.
TI Sexual dysfunction in HIV-positive men is multi-factorial: A study of
   prevalence and associated factors
SO AIDS CARE-PSYCHOLOGICAL AND SOCIO-MEDICAL ASPECTS OF AIDS/HIV
LA English
DT Article
ID ACTIVE ANTIRETROVIRAL THERAPY; ERECTILE DYSFUNCTION; PROTEASE
   INHIBITORS; PSYCHIATRIC MORBIDITY; PSYCHOSOCIAL IMPACT; METABOLIC
   SYNDROME; INFECTION
AB To establish the prevalence of sexual dysfunction amongst HIV-positive men and to determine the factors associated with dysfunction we conducted a cross-sectional study in seven European HIV treatment centres. Data on medical history, antiretroviral treatment and laboratory results were collected by interview and case record review. Sexual function was evaluated by the participant self-completion of a questionnaire based on the International Index of Erectile Function (IIEF) 711/929. Seventy-seven percent of participants returned the questionnaire. Data from 668 (72%) respondents were included. Thirty-three percent (95% CI: 29.4-36.5%) had moderate/ severe erectile dysfunction (EDF) and 24% (95% CI: 20.9-27.3%) had moderate to severe impairment of sexual desire. Variables significantly associated with EDF in multivariable analysis were older age (greater than 40 years), heterosexual status, non-alcohol drinking status, depression, antidepressants, psychotropic medications and duration of ARV therapy. Low sexual desire (LSD) was associated with older age (greater than 40 years), depression and black African ethnicity. We establish that EDF and LSD are common in both ARV naive and ARV experienced, HIV-positive individuals. Erectile dysfunction was associated with long duration of ARV treatment, with a significantly increased risk of dysfunction in the quartile with the longest period of exposure. No significant association was seen with specific classes of anti-retrovirals. Older age, and depression were the variables most consistently associated with both EDF and LSD.
C1 Chelsea & Westminster Hosp, Directorate HIV GU Med, London SW10 9NH, England.
   S Kensington & Chelsea Mental Hlth Ctr, London, England.
   Synth, Athens, Greece.
   Inst Trop Med, Dept Clin Sci, B-2000 Antwerp, Belgium.
C3 Imperial College London; Imperial College London; Institute of Tropical
   Medicine (ITM)
RP Asboe, D (corresponding author), Chelsea & Westminster Hosp, Directorate HIV GU Med, 369 Fulham Rd, London SW10 9NH, England.
EM david.asboe@chelwest.nhs.uk
RI Mayanja-Kizza, Harriet/AAM-5372-2020; Schrooten, Ward/K-3783-2015;
   Florence, Eric/JZD-7535-2024
OI Florence, Eric/0000-0002-7004-9120; SCHROOTEN, Ward/0000-0002-8659-2224;
   Colebunders, Robert/0000-0002-1919-1340
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NR 18
TC 67
Z9 71
U1 0
U2 6
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXFORDSHIRE, ENGLAND
SN 0954-0121
J9 AIDS CARE
JI Aids Care-Psychol. Socio-Med. Asp. Aids-Hiv
PY 2007
VL 19
IS 8
BP 955
EP 965
DI 10.1080/09540120701209847
PG 11
WC Health Policy & Services; Public, Environmental & Occupational Health;
   Psychology, Multidisciplinary; Respiratory System; Social Sciences,
   Biomedical
WE Social Science Citation Index (SSCI)
SC Health Care Sciences & Services; Public, Environmental & Occupational
   Health; Psychology; Respiratory System; Biomedical Social Sciences
GA 222ZA
UT WOS:000250336200001
PM 17851990
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Cremonini, E
   Iglesias, DE
   Kang, JY
   Lombardo, GE
   Mostofinejad, Z
   Wang, ZW
   Zhu, W
   Oteiza, P
AF Cremonini, Eleonora
   Iglesias, Dario E.
   Kang, Jiye
   Lombardo, Giovanni E.
   Mostofinejad, Zahra
   Wang, Ziwei
   Zhu, Wei
   Oteiza, Patricia, I
TI (-)-Epicatechin and the comorbidities of obesity
SO ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
LA English
DT Review
DE Epicatechin; Obesity; Inflammation; Intestine; Insulin resistance;
   Dyslipidemia
ID FATTY LIVER-DISEASE; IMPROVES INSULIN SENSITIVITY; CARDIOMETABOLIC
   RISK-FACTORS; DIET-INDUCED OBESITY; FLAVANOL-RICH COCOA; BODY-MASS
   INDEX; DARK CHOCOLATE; BLOOD-PRESSURE; OXIDATIVE STRESS; GUT MICROBIOTA
AB Obesity has major adverse consequences on human health contributing to the development of, among others, insulin resistance and type 2 diabetes, cardiovascular disease, non-alcoholic fatty liver disease, altered behavior and cognition, and cancer. Changes in dietary habits and lifestyle could contribute to mitigate the development and/or progression of these pathologies. This review will discuss current evidence on the beneficial actions of the flavan-3-ol (-)-epicatechin (EC) on obesity-associated comorbidities. These benefits can be in part explained through EC's capacity to mitigate several common events underlying the development of these pathologies, including: i) high circulating levels of glucose, lipids and endotoxins; ii) chronic systemic inflammation; iii) tissue endoplasmic reticulum and oxidative stress; iv) insulin resistance; v) mitochondria dysfunction and vi) dysbiosis. The currently known underlying mechanisms and cellular targets of EC's beneficial effects are discussed. While, there is limited evidence from human studies supplementing with pure EC, other studies involving cocoa supplementation in humans, pure EC in rodents and in vitro studies, support a potential beneficial action of EC on obesity-associated comorbidities. This evidence also stresses the need of further research in the field, which would contribute to the development of human dietary strategies to mitigate the adverse consequences of obesity.
C1 [Cremonini, Eleonora; Iglesias, Dario E.; Kang, Jiye; Lombardo, Giovanni E.; Mostofinejad, Zahra; Wang, Ziwei; Zhu, Wei; Oteiza, Patricia, I] Univ Calif Davis, Dept Nutr, Davis, CA 95616 USA.
   [Lombardo, Giovanni E.] Univ Messina, Dept Chem Biol Pharmaceut & Environm Sci, Messina, Italy.
C3 University of California System; University of California Davis;
   University of Messina
RP Oteiza, P (corresponding author), Univ Calif Davis, Davis, CA 95616 USA.
RI Zhu, Wei/AFK-0930-2022; Wang, Ziwei/AEH-5685-2022
OI Wang, Ziwei/0000-0002-9994-1331; Kang, Jiye/0000-0001-5673-4220; Zhu,
   Wei/0000-0002-7957-7843; Lombardo, Giovanni Enrico/0000-0003-1101-8874;
   Iglesias, Dario/0000-0003-3946-1958
FU NIFA-USDA [CA-D*-NTR-7244-H]; H.A. Jastro Graduate Research Awards (UC
   Davis); Professor Antonio Imbesi Foundation fellowship, Messina, Italy
FX This work was supported by grant NIFA-USDA (CA-D*-NTR-7244-H) to P.O.,
   H.A. Jastro Graduate Research Awards (UC Davis) to J.K. and Z.W. G.L.
   was a recipient of a Professor Antonio Imbesi Foundation fellowship,
   Messina, Italy.
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NR 183
TC 30
Z9 33
U1 1
U2 33
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0003-9861
EI 1096-0384
J9 ARCH BIOCHEM BIOPHYS
JI Arch. Biochem. Biophys.
PD SEP 15
PY 2020
VL 690
AR 108505
DI 10.1016/j.abb.2020.108505
PG 13
WC Biochemistry & Molecular Biology; Biophysics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics
GA PI3WX
UT WOS:000601026100013
PM 32679195
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Polcrova, AB
   Pavlovska, I
   Mechanick, JI
   Gonzalez-Rivas, JP
   Pikhart, H
AF Polcrova, Anna Bartoskova
   Pavlovska, Iuliia
   Mechanick, Jeffrey I.
   Gonzalez-Rivas, Juan P.
   Pikhart, Hynek
TI Dysglycemia-Based Chronic Disease and Lifestyle Medicine: Mechanistic
   Interpretation Using the Allostatic Load Model
SO AMERICAN JOURNAL OF LIFESTYLE MEDICINE
LA English
DT Review; Early Access
DE dysglycemia; diabetes; lifestyle; allostatic load
ID SOCIOECONOMIC POSITION; METABOLIC SYNDROME; STRESS; HEALTH; RISK;
   DISPARITIES; DISRUPTION; BIOMARKERS; INSOMNIA; PROGRAM
AB Dysglycemia-based chronic disease (DBCD) comprises insulin resistance, prediabetes, and type 2 diabetes, and their staged progression, complications, and impact contribute to one of the largest public health burdens worldwide. The clinical and economic effects of DBCD are fueled by external stressors related to modern society and lifestyles, especially in low socioeconomic strata. Chronic stressor exposure leads to chronic stress, characterized by immune-neuroendocrine activation and mobilization/depletion of metabolic resources. This complex adaptive response engaging many different signaling pathways is termed allostasis and principally regulates homeostatic mechanisms. Allostatic load is the metabolic cost of adaptation to environmental factors and can lead to numerous adverse health outcomes and behaviors. In this narrative review, the bidirectional relationship between allostatic load and unhealthy behaviors is analyzed in the context of DBCD development and progression, with a focus to reduce individual vulnerabilities.
C1 Masaryk Univ, Fac Sci, Brno, Czech Republic.
   Masaryk Univ, Fac Med, Dept Publ Hlth, Brno, Czech Republic.
   Icahn Sch Med Mt Sinai, Marie Josee & Henry R Kravis Ctr Cardiovasc Hlth, New York, NY USA.
   Icahn Sch Med Mt Sinai, Div Endocrinol Diabet & Bone Dis, New York, NY USA.
   St Annes Univ Hosp Brno FNUSA, Int Clin Res Ctr ICRC, Brno, Czech Republic.
   FISPEVEN INC, Fdn Clin Publ Hlth & Epidemiol Res Venezuela, Caracas, Venezuela.
   Harvard Univ, Harvard TH Chan Sch Publ Hlth, Dept Global Hlth & Populat & Epidemiol, Boston, MA USA.
   Masaryk Univ, Fac Sci, RECETOX, Brno, Czech Republic.
   UCL, Dept Epidemiol & Publ Hlth, London, England.
C3 Masaryk University Brno; Masaryk University Brno; Icahn School of
   Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai;
   Harvard University; Harvard T.H. Chan School of Public Health; Masaryk
   University Brno; University of London; University College London
RP Polcrova, AB (corresponding author), Masaryk Univ, Fac Sci, RECETOX, Kotlarska 2, Brno 60200, Czech Republic.
EM anna.bartoskova@recetox.muni.cz
RI Pavlovska, Iuliia/ISS-4979-2023; Gonzalez Rivas, Juan
   Pablo/HZK-6756-2023; Bartoskova Polcrova, Anna/HHO-1125-2022; Pikhart,
   Hynek/E-3074-2010
OI Bartoskova Polcrova, Anna/0000-0002-3358-8475; Pikhart,
   Hynek/0000-0001-5277-4049; Pavlovska, Iuliia/0000-0003-3730-3817
FU European Union's Horizon 2020 research and innovation programme [857487,
   857560]; Ministry of Education, Youth and Sports [LM2018121];
   Operational Programme Research, Development and Education (CETOCOEN
   EXCELLENCE project) [CZ.02.1.01/0.0/0.0/17_043/0009632]; National
   Institute for Research of Metabolic and Cardiovascular Diseases
   (Programme EXCELES) - European Union-Next Generation EU [LX22NPO5104]
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: This work
   has received funding from the European Union's Horizon 2020 research and
   innovation programme under grant agreements No 857487 (R-Exposome Chair)
   and No 857560 (CETOCOEN Excellence). This publication reflects only the
   author's view, and the European Commission is not responsible for any
   use that may be made of the information it contains. Authors thank the
   RECETOX Research Infrastructure (No LM2018121) financed by the Ministry
   of Education, Youth and Sports, and the Operational Programme Research,
   Development and Education (the CETOCOEN EXCELLENCE project No.
   CZ.02.1.01/0.0/0.0/17_043/0009632) for supportive background. This
   output was supported by the National Institute for Research of Metabolic
   and Cardiovascular Diseases (Programme EXCELES, ID Project No.
   LX22NPO5104)-Funded by the European Union-Next Generation EU.
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NR 53
TC 0
Z9 0
U1 1
U2 11
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1559-8276
EI 1559-8284
J9 AM J LIFESTYLE MED
JI Am. J. Lifestyle Med.
PD 2023 JUN 9
PY 2023
DI 10.1177/15598276231181074
EA JUN 2023
PG 8
WC Public, Environmental & Occupational Health
WE Emerging Sources Citation Index (ESCI)
SC Public, Environmental & Occupational Health
GA J1UN7
UT WOS:001007533200001
DA 2025-06-11
ER

PT J
AU Dragomanova, S
   Miteva, S
   Nicoletti, F
   Mangano, K
   Fagone, P
   Pricoco, S
   Staykov, H
   Tancheva, L
AF Dragomanova, Stela
   Miteva, Simona
   Nicoletti, Ferdinando
   Mangano, Katia
   Fagone, Paolo
   Pricoco, Salvatore
   Staykov, Hristian
   Tancheva, Lyubka
TI Therapeutic Potential of Alpha-Lipoic Acid in Viral Infections,
   including COVID-19
SO ANTIOXIDANTS
LA English
DT Review
DE alfa-lipoic acid; antioxidants; natural products; oxidative responses;
   viral infections
ID POLYPHENOL-RICH EXTRACT; GERANIUM-SANGUINEUM L.; CHRONIC HEPATITIS-C;
   AGE-RELATED LOSS; OXIDATIVE STRESS; LIPID-PEROXIDATION; VITAMIN-E;
   ENDOTHELIAL DYSFUNCTION; DIHYDROLIPOIC ACID; INSULIN-RECEPTOR
AB Oxidative stress (OS), resulting from a disrupted balance between reactive oxygen species (ROS) and protective antioxidants, is thought to play an important pathogenetic role in several diseases, including viral infections. Alpha-lipoic acid (LA) is one of the most-studied and used natural compounds, as it is endowed with a well-defined antioxidant and immunomodulatory profile. Owing to these properties, LA has been tested in several chronic immunoinflammatory conditions, such as diabetic neuropathy and metabolic syndrome. In addition, a pharmacological antiviral profile of LA is emerging, that has attracted attention on the possible use of this compound for the cotreatment of several viral infections. Here, we will review the emerging literature on the potential use of LA in viral infections, including COVID-19.
C1 [Dragomanova, Stela] Med Univ, Dept Pharmacol Toxicol & Pharmacotherapy, Fac Pharm, Varna 9002, Bulgaria.
   [Miteva, Simona; Tancheva, Lyubka] Bulgarian Acad Sci, Dept Behav Neurobiol, Inst Neurobiol, Sofia 1113, Bulgaria.
   [Nicoletti, Ferdinando; Mangano, Katia; Fagone, Paolo; Pricoco, Salvatore] Univ Catania, Dept Biomed & Biotechnol Sci, Via S Sofia 89, I-95123 Catania, Italy.
   [Staykov, Hristian] Med Univ, Dept Pharmacol & Toxicol, 2 Zdrave Str, Sofia 1431, Bulgaria.
C3 Medical University Varna; Bulgarian Academy of Sciences; University of
   Catania; Medical University Sofia
RP Nicoletti, F (corresponding author), Univ Catania, Dept Biomed & Biotechnol Sci, Via S Sofia 89, I-95123 Catania, Italy.
EM stela_dragomanova@abv.bg; saalexandrova@gmail.com; ferdinic@unict.it;
   kmangano@unict.it; paolofagone@yahoo.it; salvatore.pricoco@yahoo.it;
   drhristianstaykov@gmail.com; lyubkatancheva@gmail.com
RI Dragomanova, Stela/GQA-5952-2022; NICOLETTI, Ferdinando/M-4428-2016;
   Fagone, Paolo/Q-4455-2016; Mangano, Katia/Q-1156-2016
OI NICOLETTI, Ferdinando/0000-0002-4570-8462; Dragomanova,
   Stela/0000-0003-1845-2753; Fagone, Paolo/0000-0002-6694-1992;
   Aleksandrova, Simona/0000-0002-4587-6255; Mangano,
   Katia/0000-0001-5920-4620
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NR 107
TC 22
Z9 22
U1 0
U2 10
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD AUG
PY 2021
VL 10
IS 8
AR 1294
DI 10.3390/antiox10081294
PG 12
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA UF5FU
UT WOS:000688600700001
PM 34439542
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Dandona, P
   Aljada, A
   Bandyopadhyay, A
AF Dandona, P
   Aljada, A
   Bandyopadhyay, A
TI Inflammation: the link between insulin resistance, obesity and diabetes
SO TRENDS IN IMMUNOLOGY
LA English
DT Article
ID TUMOR-NECROSIS-FACTOR; C-REACTIVE PROTEIN; PLASMINOGEN-ACTIVATOR
   INHIBITOR-1; FACTOR-KAPPA-B; FACTOR-ALPHA; ADIPOSE-TISSUE; WEIGHT-LOSS;
   CARDIOVASCULAR-DISEASE; ATHEROSCLEROSIS RISK; METABOLIC SYNDROME
AB Recent data have revealed that the plasma concentration of inflammatory mediators, such as tumour necrosis factor-alpha (TNF-alpha) and interieukin-6 (IL-6), is increased in the insulin resistant states of obesity and type 2 diabetes, raising questions about the mechanisms underlying inflammation in these two conditions. It is also intriguing that an increase in inflammatory mediators or indices predicts the future development of obesity and diabetes. Two mechanisms might be involved in the pathogenesis of inflammation. Firstly, glucose and macronutrient intake causes oxidative stress and inflammatory changes. Chronic overnutrition (obesity) might thus be a proinflammatory state with oxidative stress. Secondly, the increased concentrations of TNF-alpha and IL-6, associated with obesity and type 2 diabetes, might interfere with insulin action by suppressing insulin signal transduction. This might interfere with the anti-inflammatory effect of insulin, which in turn might promote inflammation.
C1 SUNY Coll Buffalo, Div Endocrinol Diabet & Metab, Buffalo, NY 14209 USA.
   Kaleida Hlth, Buffalo, NY 14209 USA.
C3 State University of New York (SUNY) System; Buffalo State University;
   Kaleida Health
RP Dandona, P (corresponding author), SUNY Coll Buffalo, Div Endocrinol Diabet & Metab, 3 Gates Circle, Buffalo, NY 14209 USA.
EM pdandona@kaleidahealth.org
RI Aljada, Ahmad/KYQ-4122-2024; Basili, Stefania/K-4024-2016
OI Aljada, Ahmad/0000-0001-8337-5454; Basili, Stefania/0000-0002-6987-1926
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NR 41
TC 1662
Z9 1934
U1 5
U2 237
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1471-4906
J9 TRENDS IMMUNOL
JI Trends Immunol.
PD JAN
PY 2004
VL 25
IS 1
BP 4
EP 7
DI 10.1016/j.it.2003.10.013
PG 4
WC Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology
GA 767GL
UT WOS:000188431800002
PM 14698276
DA 2025-06-11
ER

PT J
AU Madaris, TR
   Venkatesan, M
   Maity, S
   Stein, MC
   Vishnu, N
   Venkateswaran, MK
   Davis, JG
   Ramachandran, K
   Uthayabalan, S
   Allen, C
   Osidele, A
   Stanley, K
   Bigham, NP
   Bakewell, TM
   Narkunan, M
   Le, A
   Karanam, V
   Li, K
   Mhapankar, A
   Norton, L
   Ross, J
   Aslam, MI
   Reeves, WB
   Singh, BB
   Caplan, J
   Wilson, JJ
   Stathopulos, PB
   Baur, JA
   Madesh, M
AF Madaris, Travis R.
   Venkatesan, Manigandan
   Maity, Soumya
   Stein, Miriam C.
   Vishnu, Neelanjan
   Venkateswaran, Mridula K.
   Davis, James G.
   Ramachandran, Karthik
   Uthayabalan, Sukanthathulse
   Allen, Cristel
   Osidele, Ayodeji
   Stanley, Kristen
   Bigham, Nicholas P.
   Bakewell, Terry M.
   Narkunan, Melanie
   Le, Amy
   Karanam, Varsha
   Li, Kang
   Mhapankar, Aum
   Norton, Luke
   Ross, Jean
   Aslam, M. Imran
   Reeves, W. Brian
   Singh, Brij B.
   Caplan, Jeffrey
   Wilson, Justin J.
   Stathopulos, Peter B.
   Baur, Joseph A.
   Madesh, Muniswamy
TI Limiting Mrs2-dependent mitochondrial Mg2+uptake induces metabolic
   programming in prolonged dietary stress
SO CELL REPORTS
LA English
DT Article
ID CALCIUM UNIPORTER; LIPID-METABOLISM; HYPOXIA; MG2+; EXPRESSION;
   DYNAMICS; GENES; HISAT; CA2+; HOMEOSTASIS
AB The most abundant cellular divalent cations, Mg2+ (mM) and Ca2+ (nM-mM), antagonistically regulate diver-gent metabolic pathways with several orders of magnitude affinity preference, but the physiological signifi-cance of this competition remains elusive. In mice consuming a Western diet, genetic ablation of the mitochondrial Mg2+ channel Mrs2 prevents weight gain, enhances mitochondrial activity, decreases fat accu-mulation in the liver, and causes prominent browning of white adipose. Mrs2 deficiency restrains citrate efflux from the mitochondria, making it unavailable to support de novo lipogenesis. As citrate is an endogenous Mg2+ chelator, this may represent an adaptive response to a perceived deficit of the cation. Transcriptional profiling of liver and white adipose reveals higher expression of genes involved in glycolysis, b-oxidation, thermogenesis, and HIF-1a-targets, in Mrs2-/- mice that are further enhanced under Western-diet -associ-ated metabolic stress. Thus, lowering mMg2+ promotes metabolism and dampens diet-induced obesity and metabolic syndrome.
C1 [Madaris, Travis R.; Venkatesan, Manigandan; Maity, Soumya; Stein, Miriam C.; Vishnu, Neelanjan; Venkateswaran, Mridula K.; Ramachandran, Karthik; Allen, Cristel; Osidele, Ayodeji; Stanley, Kristen; Narkunan, Melanie; Le, Amy; Karanam, Varsha; Li, Kang; Mhapankar, Aum; Norton, Luke; Reeves, W. Brian; Singh, Brij B.; Madesh, Muniswamy] Univ Texas Hlth San Antonio, Ctr Mitochondrial Med, Dept Med, San Antonio, TX 78229 USA.
   [Madaris, Travis R.; Venkatesan, Manigandan; Maity, Soumya; Stein, Miriam C.; Vishnu, Neelanjan; Venkateswaran, Mridula K.; Ramachandran, Karthik; Allen, Cristel; Osidele, Ayodeji; Stanley, Kristen; Bakewell, Terry M.; Narkunan, Melanie; Le, Amy; Karanam, Varsha; Li, Kang; Mhapankar, Aum; Norton, Luke; Aslam, M. Imran; Reeves, W. Brian; Madesh, Muniswamy] Univ Texas Hlth San Antonio, Dept Med, Cardiol Diabet Div, San Antonio, TX 78229 USA.
   [Davis, James G.; Baur, Joseph A.] Univ Penn, Dept Physiol, Philadelphia, PA 19103 USA.
   [Davis, James G.; Baur, Joseph A.] Univ Penn, Inst Diabet Obes & Metab, Philadelphia, PA 19103 USA.
   [Uthayabalan, Sukanthathulse; Stathopulos, Peter B.] Western Univ, Dept Physiol & Pharmacol, London, ON N6A 5C1, Canada.
   [Bigham, Nicholas P.; Wilson, Justin J.] Cornell Univ, Dept Chem & Chem Biol, Ithaca, NY 14853 USA.
   [Ross, Jean; Caplan, Jeffrey] Univ Delaware, Delaware Biotechnol Inst, Dept Biol Sci, Newark, DE 19711 USA.
C3 University of Texas System; University of Texas Health Science Center at
   San Antonio; University of Texas System; University of Texas Health
   Science Center at San Antonio; University of Pennsylvania; University of
   Pennsylvania; Western University (University of Western Ontario);
   Cornell University; University of Delaware
RP Madesh, M (corresponding author), Univ Texas Hlth San Antonio, Ctr Mitochondrial Med, Dept Med, San Antonio, TX 78229 USA.; Madesh, M (corresponding author), Univ Texas Hlth San Antonio, Dept Med, Cardiol Diabet Div, San Antonio, TX 78229 USA.; Baur, JA (corresponding author), Univ Penn, Dept Physiol, Philadelphia, PA 19103 USA.
EM baur@pennmedicine.upenn.edu; muniswamy@uthscsa.edu
RI Baur, Joseph/D-8163-2011; vishnu, Neelanjan/IUQ-2907-2023; Norton,
   Luke/F-6685-2015; Bigham, Nicholas/GPS-9759-2022; Venkatesan,
   Manigandan/L-5772-2013
OI Venkatesan, Manigandan/0000-0003-0044-4472; Stathopulos, Peter
   B./0000-0002-0536-6656; Aslam, Mohammed/0000-0003-4560-8661;
   Ramachandran, Karthik/0000-0003-3673-3559; Vishnu,
   Neelanjan/0009-0002-6223-8316
FU National Institutes of Health [R35GM145294, R01GM109882, R01DK135179,
   R01HL142673]; DOD/DHP-CDMRP [PR181598P-1]; San Antonio Partnership for
   Precision Therapeutics (SAPPT); National Science Foundation
   [CIHR-438225]; NIH [CHE-1750295]; Penn Diabetes Research Center
   [R01GM109882-S1, T32 AG 021890];  [P30-DK19525];  [S10-OD025098]
FX We thank Robert Campbell and William G. Kaelin Jr for sharing the
   cyto-Citron1 (addgene#134303) and mito-Citron1 (addgene#134305) plasmids
   and HIF1-a mutant (addgene#87261) constructs. We also thank the
   Department of Pathology and Laboratory Medicine histology core facility
   at UTHSA for histology preparation/staining. This research was funded by
   the National Institutes of Health (R35GM145294, R01GM109882,
   R01DK135179, and R01HL142673) to M.M. This work was partly supported by
   DOD/DHP-CDMRP PR181598P-1 and San Antonio Partnership for Precision
   Therapeutics (SAPPT) to M.M., CIHR-438225 to P.B.S., and National
   Science Foundation (CHE-1750295) to J.J.W. T.R.M. is supported by the
   NIH (R01GM109882-S1 and T32 AG 021890). We thank the Rodent Metabolic
   Phenotyping Core, supported in part by the Penn Diabetes Research Center
   grant (P30-DK19525) and S10-OD025098.
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NR 75
TC 15
Z9 16
U1 2
U2 15
PU CELL PRESS
PI CAMBRIDGE
PA 50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA
SN 2211-1247
J9 CELL REP
JI Cell Reports
PD MAR 28
PY 2023
VL 42
IS 3
AR 112155
DI 10.1016/j.celrep.2023.112155
EA FEB 2023
PG 26
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA 9X0SV
UT WOS:000949485700001
PM 36857182
OA gold, Green Accepted
DA 2025-06-11
ER

PT J
AU Ullah, R
   Rauf, N
   Nabi, G
   Ullah, H
   Shen, Y
   Zhou, YD
   Fu, JF
AF Ullah, Rahim
   Rauf, Naveed
   Nabi, Ghulam
   Ullah, Hamid
   Shen, Yi
   Zhou, Yu-Dong
   Fu, Junfen
TI Role of Nutrition in the Pathogenesis and Prevention of Non-alcoholic
   Fatty Liver Disease: Recent Updates
SO INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
LA English
DT Review
DE nutrition; hepatic inflammation; NAFLD pathogenesis; prevention
ID DIETARY-PROTEIN RESTRICTION; CONJUGATED LINOLEIC-ACID; VITAMIN-D
   DEFICIENCY; INSULIN-RESISTANCE; RISK-FACTORS; METABOLIC SYNDROME;
   HEPATIC STEATOSIS; OXIDATIVE STRESS; LOW-CARBOHYDRATE; INFLAMMATORY
   BIOMARKERS
AB Non-alcoholic fatty liver disease (NAFLD) is an acquired metabolic disease characterized by triglycerides (TGs) deposition in liver induced by other factors rather than alcohol consumption. NAFLD significantly contributes to liver diseases in children and adults. NAFLD pathogenesis is associated with age, gender, race and ethnicity. Insulin resistance, hyperinsulinemia, elevated plasma free fatty acids (FFAs), fatty liver, hepatocyte injury, liver inflammation, oxidative stress, mitochondrial dysfunction, imbalanced pro-inflammatory cytokines, and fibrosis are the characteristics of NAFLD. Factors including genetic and epigenetic pathways, sedentary lifestyle, sleep, and diet composition affect NAFLD pathogenesis. In this review, we discuss the aetiology, risk factors and pathogenesis of NAFLD. Special focus is given to macro and micro nutrition as causing factors and their role in the prevention of NAFLD pathogenesis.
C1 [Ullah, Rahim; Rauf, Naveed; Fu, Junfen] Zhejiang Univ, Sch Med, Childrens Hosp, Dept Endocrinol, Hangzhou 310051, Zhejiang, Peoples R China.
   [Ullah, Rahim; Rauf, Naveed; Shen, Yi; Zhou, Yu-Dong] Zhejiang Univ, Sch Med, Inst Neurosci, Dept Neurobiol, Hangzhou 310058, Zhejiang, Peoples R China.
   [Ullah, Rahim; Rauf, Naveed; Shen, Yi; Zhou, Yu-Dong] Zhejiang Univ, Sch Med, Minist Hlth China, Collaborat Innovat Ctr Brain Sci,Key Lab Med Neur, Hangzhou 310058, Zhejiang, Peoples R China.
   [Nabi, Ghulam] Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Hubei, Peoples R China.
   [Ullah, Hamid] Quaid I Azam Univ, Fac Biol Sci, Dept Anim Sci, Lab Reprod Neuroendocrinol, Islamabad, Pakistan.
C3 Zhejiang University; Zhejiang University; Zhejiang University; Chinese
   Academy of Sciences; Institute of Hydrobiology, CAS; Quaid I Azam
   University
RP Fu, JF (corresponding author), Zhejiang Univ, Sch Med, Childrens Hosp, Dept Endocrinol, Hangzhou 310051, Zhejiang, Peoples R China.; Zhou, YD (corresponding author), Zhejiang Univ, Sch Med, Inst Neurosci, Dept Neurobiol, Hangzhou 310058, Zhejiang, Peoples R China.; Zhou, YD (corresponding author), Zhejiang Univ, Sch Med, Minist Hlth China, Collaborat Innovat Ctr Brain Sci,Key Lab Med Neur, Hangzhou 310058, Zhejiang, Peoples R China.
EM yudongzhou@zju.edu.cn; fjf68@qq.com
RI Ullah, Rahim/JVM-7749-2024; Nabi, Ghulam/AGQ-2183-2022; Rauf,
   Naveed/JQJ-6050-2023
OI Nabi, Ghulam/0000-0001-5256-0083; Zhou, Yu-Dong/0000-0002-6364-3869
FU National Key Research and Development Programme of China [2016YFC1305
   301]; National Natural Science Foundation of China [81570759, 81270938];
   Zhejiang Provincial Key Science and Technology Project [2014C030452];
   Key Disciplines of Medicine (Innovation discipline) [11-CX24];
   Fundamental Research Funds for the Central Universities [2017XZZX001-01]
FX The authors gratefully acknowledge the financial support from the
   National Key Research and Development Programme of China (No.
   2016YFC1305 301), National Natural Science Foundation of China (Nos.
   81570759 and 81270938), Zhejiang Provincial Key Science and Technology
   Project (No. 2014C030452), Key Disciplines of Medicine (Innovation
   discipline, 11-CX24) and the Fundamental Research Funds for the Central
   Universities (2017XZZX001-01). No specific grant from any funding
   agency, commercial or not-for-profit sectors supported the current work.
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NR 126
TC 101
Z9 107
U1 0
U2 41
PU IVYSPRING INT PUBL
PI LAKE HAVEN
PA PO BOX 4546, LAKE HAVEN, NSW 2263, AUSTRALIA
SN 1449-2288
J9 INT J BIOL SCI
JI Int. J. Biol. Sci.
PY 2019
VL 15
IS 2
BP 265
EP 276
DI 10.7150/ijbs.30121
PG 12
WC Biochemistry & Molecular Biology; Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics
GA HF9FU
UT WOS:000454548700002
PM 30745819
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Spoletini, I
   Vitale, C
   Rosano, GMC
AF Spoletini, Ilaria
   Vitale, Cristiana
   Rosano, Giuseppe M. C.
TI Biomarkers for predicting postmenopausal coronary heart disease
SO BIOMARKERS IN MEDICINE
LA English
DT Review
DE atherosclerosis; biomarkers; coronary heart disease; dyslipidemia;
   hormone therapy; inflammation; menopause; oxidative stress
ID C-REACTIVE-PROTEIN; HORMONE REPLACEMENT THERAPY; SERUM URIC-ACID;
   ESTROGEN PLUS PROGESTIN; CARDIOVASCULAR RISK PREDICTION; METABOLIC
   SYNDROME; WOMENS HEALTH; INFLAMMATORY BIOMARKERS; ATHEROSCLEROSIS RISK;
   MULTIPLE BIOMARKERS
AB Coronary heart disease (CHD) is the main cause of death in post-menopausal women (PMW). Beyond the 'traditional' cardiovascular risk factors of CHD, newer biomarkers, reflecting inflammation, endothelial function and oxidative stress, have received growing consideration. We systematically reviewed the literature on the biomarkers for predicting CHD in PMW. C-reactive protein, IL-6 and Lipoprotein (a) have been consistently found to be associated with CHD risk in PMW. However, no evidence supports the existence of a causal and independent link between such biomarkers and CHD in PMW. Also, the new biomarkers only marginally improve cardiovascular risk prediction. Upcoming studies are needed to provide further evidence on the validity of the new biomarkers in PMW and to understand their relationships with hormone therapy, opening new avenues for prevention.
C1 [Spoletini, Ilaria; Vitale, Cristiana; Rosano, Giuseppe M. C.] IRCCS San Raffaele Pisana, Ctr Clin & Basic Res, I-00163 Rome, Italy.
   [Rosano, Giuseppe M. C.] San Raffaele Sulmona, Clin Res Ctr, Sulmona, Italy.
C3 IRCCS San Raffaele Pisana; Center Clinical & Basic Research
RP Rosano, GMC (corresponding author), IRCCS San Raffaele Pisana, Ctr Clin & Basic Res, Via Pisana 235, I-00163 Rome, Italy.
EM giuseppe.rosano@sanraffaele.it
RI Spoletini, Ilaria/AAL-4449-2020; Rosano, Giuseppe/K-8718-2018; Vitale,
   Cristiana/P-8030-2016
OI Vitale, Cristiana/0000-0003-1111-9894
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NR 101
TC 6
Z9 8
U1 0
U2 8
PU FUTURE MEDICINE LTD
PI LONDON
PA UNITEC HOUSE, 3RD FLOOR, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON, N3
   1QB, ENGLAND
SN 1752-0363
EI 1752-0371
J9 BIOMARK MED
JI Biomark. Med.
PD AUG
PY 2011
VL 5
IS 4
BP 485
EP 495
DI 10.2217/BMM.11.51
PG 11
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 836VB
UT WOS:000296141300018
PM 21861670
DA 2025-06-11
ER

PT J
AU Walenna, NF
   Kurihara, Y
   Chou, B
   Ishii, K
   Soejima, T
   Hiromatsu, K
AF Walenna, Nirwana Fitriani
   Kurihara, Yusuke
   Chou, Bin
   Ishii, Kazunari
   Soejima, Toshinori
   Hiromatsu, Kenji
TI Chlamydia pneumoniae infection?induced endoplasmic reticulum
   stress causes fatty acid?binding protein 4 secretion in murine
   adipocytes
SO JOURNAL OF BIOLOGICAL CHEMISTRY
LA English
DT Article
DE Chlamydia; bacteria; infection; adipocyte; fatty acid binding protein;
   endoplasmic reticulum stress (ER stress); lipolysis; unfolded protein
   response (UPR); oxidative stress; metabolic disorder
ID ACID-BINDING PROTEIN; INTRACELLULAR GROWTH; INSULIN-RESISTANCE;
   RISK-FACTOR; ER STRESS; ATHEROSCLEROSIS; MECHANISMS; FABP4; AP2
AB Fatty acid?binding protein 4 (FABP4) is predominantly expressed in adipocytes and macrophages and regulates metabolic and inflammatory pathways. FABP4 is secreted from adipocytes during lipolysis, and elevated circulating FABP4 levels are associated with obesity, metabolic disease, and cardiac dysfunction. We previously reported that the bacterial respiratory pathogen Chlamydia pneumoniae infects murine adipocytes and exploits host FABP4 to mobilize fat and replicate within adipocytes. However, whether C. pneumoniae induces FABP4 secretion from adipocytes has not been determined. Here, we show that FABP4 is actively secreted by murine adipocytes upon C. pneumoniae infection. Chemical inhibition of lipase activity and genetic deficiency of hormone-sensitive lipase blocked FABP4 secretion from C. pneumoniae?infected adipocytes. Mechanistically, C. pneumoniae infection induced endoplasmic reticulum (ER) stress and the unfolded protein response (UPR), resulting in elevated levels of mitochondrial reactive oxygen species and cytosolic Ca2+. Of note, exposure to a mitochondrial reactive oxygen species?specific scavenger, MitoTEMPO, reduced FABP4 release from C. pneumoniae?infected adipocytes. Furthermore, treatment with azoramide, which protects cells against ER stress, decreased FABP4 release from C. pneumoniae?infected adipocytes. Using gene silencing of CHOP (C/EBP homologous protein), a central regulator of ER stress, we further validated the role of C. pneumoniae infection?induced ER stress/UPR in promoting FABP4 secretion. Overall, these results indicate that C. pneumoniae infection robustly induces FABP4 secretion from adipocytes by stimulating ER stress/UPR. Our findings shed additional light on the etiological link between C. pneumoniae infection and metabolic syndrome.
C1 [Walenna, Nirwana Fitriani; Kurihara, Yusuke; Chou, Bin; Ishii, Kazunari; Soejima, Toshinori; Hiromatsu, Kenji] Fukuoka Univ, Fac Med, Dept Microbiol & Immunol, Fukuoka 8140180, Japan.
   [Walenna, Nirwana Fitriani] Kyushu Univ, Grad Sch Med Sci, Dept Bacteriol, Higashi Ku, Fukuoka 8128582, Japan.
   [Walenna, Nirwana Fitriani] Hasanuddin Univ, Fac Med, Makassar, South Sulawesi, Indonesia.
C3 Fukuoka University; Kyushu University; Universitas Hasanuddin
RP Hiromatsu, K (corresponding author), Fukuoka Univ, Fac Med, Dept Microbiol & Immunol, Jonan Ku, 7-45-1 Nanakuma, Fukuoka, Fukuoka 8140180, Japan.
EM khiromatsu@fukuoka-u.ac.jp
RI Walenna, Nirwana Fitriani/AAC-7560-2020
OI Walenna, Nirwana Fitriani/0000-0002-3992-5604
FU Japan Society for the Promotion of Science [19K166590002]; Indonesia
   Endowment Fund for Education scholarship from Ministry of Finance of the
   Republic of Indonesia
FX This work was supported in part by Japan Society for the Promotion of
   Science Grant-in-Aid for Scientific Research 19K166590002. This work was
   also supported in part by an Indonesia Endowment Fund for Education
   scholarship from Ministry of Finance of the Republic of Indonesia (to N.
   F. W.). The authors declare that they have no conflicts of interest with
   the contents of this article.
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Z9 17
U1 0
U2 7
PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
PI ROCKVILLE
PA 11200 ROCKVILLE PIKE, SUITE 302, ROCKVILLE, MD, UNITED STATES
SN 0021-9258
EI 1083-351X
J9 J BIOL CHEM
JI J. Biol. Chem.
PD FEB 28
PY 2020
VL 295
IS 9
BP 2713
EP 2723
DI 10.1074/jbc.RA119.010683
PG 11
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA KU8NN
UT WOS:000519969100016
PM 31992597
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Liu, LC
   Wang, Y
   Zhang, J
   Wang, C
   Li, YB
   Dai, WC
   Piao, CH
   Liu, JM
   Yu, HS
   Li, X
   Wang, YH
   Liu, JS
AF Liu, Lingchong
   Wang, Yu
   Zhang, Jing
   Wang, Chao
   Li, Youbao
   Dai, Weichang
   Piao, Chunhong
   Liu, Junmei
   Yu, Hansong
   Li, Xia
   Wang, Yuhua
   Liu, Jingsheng
TI Probiotics in treating with alcoholic liver disease and nonalcoholic
   fatty liver disease
SO FOOD REVIEWS INTERNATIONAL
LA English
DT Review
DE Pathogenesis; gut permeability; insulin resistance; oxidative stress;
   triglyceride
ID DOUBLE-BLIND; INSULIN-RESISTANCE; OXIDATIVE STRESS;
   LACTOBACILLUS-ACIDOPHILUS; GUT MICROBIOTA; RAT MODEL; STEATOHEPATITIS;
   OBESITY; NAFLD; PATHOGENESIS
AB Alcoholic liver disease (ALD) and nonalcoholic fatty liver disease (NAFLD) are both serious chronic liver diseases worldwide. The cause of ALD is chronic alcoholism. NAFLD is a metabolic syndrome caused by excessive accumulation of triglycerides in liver cells without consumption of alcohol. Although the pathogeneses of these two liver diseases are different, the traditional treatments for these two liver diseases are mainly drug treatment. Drug treatment works quickly, but long-term use may produce side effects. Studies demonstrated that probiotics as a natural substance played a unique role in improving liver and intestinal health. This review overviews the pathogenesis of ALD and NAFLD, summarizes the health effects of probiotics in the treatment of ALD and NAFLD, and discusses the treating mechanisms of probiotics in order to provide a theoretical basis for future research.
C1 [Liu, Lingchong; Wang, Yu; Zhang, Jing; Wang, Chao; Li, Youbao; Dai, Weichang; Piao, Chunhong; Liu, Junmei; Yu, Hansong; Li, Xia; Wang, Yuhua; Liu, Jingsheng] Jilin Agr Univ, Coll Food Sci & Engn, Changchun, Jilin, Peoples R China.
   [Liu, Lingchong; Wang, Yu; Zhang, Jing; Wang, Chao; Li, Youbao; Dai, Weichang; Piao, Chunhong; Liu, Junmei; Yu, Hansong; Li, Xia; Wang, Yuhua; Liu, Jingsheng] Jilin Agr Univ, Jilin Prov Innovat Ctr Food Biol Mfg, Dept Food Sci & Engn, Changchun, Jilin, Peoples R China.
   [Liu, Lingchong] Changchun Sci Tech Univ, Coll Life Sci, Changchun, Jilin, Peoples R China.
   [Li, Youbao; Dai, Weichang; Piao, Chunhong; Liu, Junmei; Yu, Hansong; Li, Xia; Wang, Yuhua; Liu, Jingsheng] Natl Proc Lab Soybean Ind & Technol, Dept Food Sci & Engn, Changchun, Jilin, Peoples R China.
   [Li, Youbao; Dai, Weichang; Piao, Chunhong; Liu, Junmei; Yu, Hansong; Li, Xia; Wang, Yuhua; Liu, Jingsheng] Natl Engn Lab Wheat & Corn Deep Proc, Dept Food Sci & Engn, Changchun, Jilin, Peoples R China.
C3 Jilin Agricultural University; Jilin Agricultural University
RP Wang, YH (corresponding author), Natl Proc Lab Soybean Ind & Technol, Dept Food Sci & Engn, Changchun, Jilin, Peoples R China.
EM yuhua-ww@163.com
RI piao, chunhong/HDM-7634-2022
FU Jilin province government Project [20200403163SF]; National Key Research
   and Development Program of China [2017YFE0105400]
FX This work was supported by the Jilin province government Project
   [20200403163SF]; National Key Research and Development Program of China
   [2017YFE0105400].
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NR 138
TC 7
Z9 7
U1 12
U2 63
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 8755-9129
EI 1525-6103
J9 FOOD REV INT
JI Food Rev. Int.
PD JUL 4
PY 2023
VL 39
IS 5
BP 2723
EP 2741
DI 10.1080/87559129.2021.1967380
EA SEP 2021
PG 19
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA M6RI9
UT WOS:000692575200001
DA 2025-06-11
ER

PT J
AU Ciciliot, S
   Fadini, GP
AF Ciciliot, Stefano
   Fadini, Gian Paolo
TI Modulation of Obesity and Insulin Resistance by the Redox Enzyme and
   Adaptor Protein p66<SUP>Shc</SUP>
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE diabetes; metabolic syndrome; adipose tissue; muscle; glucose tolerance;
   aging; oxidative stress
ID LIFE-SPAN DETERMINANT; OXIDATIVE STRESS; MAMMALIAN LONGEVITY; DIETARY
   RESTRICTION; KINASE-C; P66SHC; METABOLISM; SHC; MICE; ISOFORM
AB Initially reported as a longevity-related protein, the 66 kDa isoform of the mammalian Shc1 locus has been implicated in several metabolic pathways, being able to act both as an adaptor protein and as a redox enzyme capable of generating reactive oxygen species (ROS) when it localizes to the mitochondrion. Ablation of p66(Shc) has been shown to be protective against obesity and the insurgence of insulin resistance, but not all the studies available in the literature agree on these points. This review will focus in particular on the role of p66(Shc) in the modulation of glucose homeostasis, obesity, body temperature, and respiration/energy expenditure. In view of the obesity and diabetes epidemic, p66(Shc) may represent a promising therapeutic target with enormous implications for human health.
C1 [Ciciliot, Stefano; Fadini, Gian Paolo] Veneto Inst Mol Med, I-35128 Padua, Italy.
   [Fadini, Gian Paolo] Univ Padua, Dept Med, I-35128 Padua, Italy.
C3 Veneto Institute Molecular Medicine; University of Padua
RP Fadini, GP (corresponding author), Veneto Inst Mol Med, I-35128 Padua, Italy.; Fadini, GP (corresponding author), Univ Padua, Dept Med, I-35128 Padua, Italy.
EM stefano.ciciliot@gmail.com; gianpaolofadini@hotmail.com
RI Fadini, Gian/M-4575-2019; Ciciliot, Stefano/L-3887-2019
OI Ciciliot, Stefano/0000-0002-5833-6581; FADINI, GIAN
   PAOLO/0000-0002-6510-2097
FU University of Padova [2019-UNPD0Z9-0058438]; Italian Ministry of
   Education and University, grant PRIN [2015ZTT5KB]
FX This research was funded by the University of Padova, grant No.
   2019-UNPD0Z9-0058438, and by the Italian Ministry of Education and
   University, grant PRIN No. 2015ZTT5KB.
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NR 60
TC 21
Z9 22
U1 0
U2 5
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD FEB 2
PY 2019
VL 20
IS 4
AR 985
DI 10.3390/ijms20040985
PG 11
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA HO3FO
UT WOS:000460805400193
PM 30813483
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Orrù, G
   Storari, M
   Scano, A
   Piras, V
   Taibi, R
   Viscuso, D
AF Orru, G.
   Storari, M.
   Scano, A.
   Piras, V
   Taibi, R.
   Viscuso, D.
TI Obstructive Sleep Apnea, oxidative stress, inflammation and endothelial
   dysfunction-An overview of predictive laboratory biomarkers
SO EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
LA English
DT Article
DE Sleep apnea; Oxidative stress; Inflammation; Endothelial dysfunction
ID C-REACTIVE PROTEIN; POSITIVE AIRWAY PRESSURE; NITRIC-OXIDE LEVELS;
   CARDIOVASCULAR-DISEASE; LIPID-PEROXIDATION; INSULIN-RESISTANCE;
   METABOLIC SYNDROME; MOLECULAR-CLONING; PROGENITOR CELLS; REPAIR CAPACITY
AB OBJECTIVE: Obstructive Sleep Apnea (OSA) represents an emerging public health concern with great impact on cardiovascular state. Oxidative stress (OS), inflammation and altered Nitric Oxide (NO) production are recognized as prominent mechanisms of many acute and chronic diseases and even of the normal aging process. They are investigated as major pathophysiological processes in OSA through the analysis and comparison of significative and validated biomarkers.
   MATERIALS AND METHODS: The review is developed using as key terms "sleep apnea", "oxidative stress", "inflammation", and "endothelial dysfunction". Included studies must have followed the American Academy of Sleep Medicine guidelines according to the diagnosis and classification of OSA. Lipid, protein and DNA oxidation products, PCR, IL-6, IL-8, TNF-alpha, NO and nitrosative stress compounds, and endothelial functioning tests have been detected for their contribution in OSA along the last 3 decades.
   RESULTS: Nocturnal intermittent hypoxia has emerged to be significantly associated to oxidative/nitrosative stress, increase in pro-inflammatory markers, imbalance in NO production, and endothelium impairment. Body Mass Index (BMI) contribution needs further clarifications. Continuous Positive Airway Pressure (CPAP) therapy has demonstrated beneficial effects on vascular function and pro-inflammatory milieu in OSA.
   CONCLUSIONS: Oxidative stress and Inflammation significantly correlate with OSA; similarly, vascular functioning is impaired in accordance to unregulated levels of NO and derived compounds. Continuous Positive Airway Pressure markedly improves oxidative stress, inflammation and endothelial dysfunction in OSA.
C1 [Orru, G.; Scano, A.] Univ Cagliari, Dept Surg Sci, Mol Biol Serv MBS, Cagliari, Italy.
   [Storari, M.; Piras, V; Viscuso, D.] Univ Cagliari, Inst Dent, Dept Surg Sci, Cagliari, Italy.
   [Taibi, R.] Ist Nazl Tumori, Dept Med Oncol, Ctr Riferimento Oncol Aviano, Aviano, PN, Italy.
C3 University of Cagliari; University of Cagliari; Fondazione IRCCS
   Istituto Nazionale Tumori Milan; IRCCS Aviano (CRO)
RP Viscuso, D (corresponding author), Univ Cagliari, Inst Dent, Dept Surg Sci, Cagliari, Italy.
EM d.viscuso@libero.it
RI Scano, Alessandra/HPE-0928-2023
OI Scano, Alessandra/0000-0002-4385-8002; Storari,
   Marco/0000-0002-4251-0426
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NR 97
TC 97
Z9 104
U1 1
U2 18
PU VERDUCI PUBLISHER
PI ROME
PA VIA GREGORIO VII, ROME, 186-00165, ITALY
SN 1128-3602
J9 EUR REV MED PHARMACO
JI Eur. Rev. Med. Pharmacol. Sci.
PY 2020
VL 24
IS 12
BP 6939
EP 6948
PG 10
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA MD5SR
UT WOS:000544032800057
PM 32633387
DA 2025-06-11
ER

PT J
AU Kalyan, S
   Patel, MS
   Kingwell, E
   Côté, HCF
   Liu, DM
   Prior, JC
AF Kalyan, Shirin
   Patel, Millan S.
   Kingwell, Elaine
   Cote, Helene C. F.
   Liu, Danmei
   Prior, Jerilynn C.
TI Competing Factors Link to Bone Health in Polycystic Ovary Syndrome:
   Chronic Low-Grade Inflammation Takes a Toll
SO SCIENTIFIC REPORTS
LA English
DT Article
ID LEUKOCYTE TELOMERE LENGTH; MINERAL DENSITY; POSTMENOPAUSAL WOMEN;
   CARDIOMETABOLIC RISK; OXIDATIVE STRESS; MUSCLE SIZE; FRACTURE; PCOS;
   PREMENOPAUSAL; STRENGTH
AB Chronic inflammation predisposes to poor bone health. Women with polycystic ovary syndrome (PCOS) experience androgen excess, ovulatory disturbances, insulin resistance, abdominal adiposity and chronic inflammation. Our objective was to investigate the relationships among bone health parameters, chronic subclinical inflammation and anthropometric measures in premenopausal women with and without PCOS. In 61 premenopausal women, 22 women with PCOS and 39 controls, we assessed bone parameters (total hip bone mineral density [BMD] by dual-energy X-ray absorptiometry and radius strength-strain index [SSI] by peripheral quantitative computed tomography), inflammation (C-reactive protein/albumin), oxidative stress (leukocyte telomere length, urinary 8-hydroxydeoxyguanosine); hemoglobin A1c; anthropometric measures (body mass index, waist-to-height ratio, cross-sectional muscle area). A diagnosis of PCOS negatively predicted (beta = -0.251, p = 0.022) hip BMD in a regression model including weight. In women with PCOS, inflammation, which was predicted by increased waist-to-height ratio and current use of oral contraceptives, attenuated the positive influences of increased weight and muscle mass on bone strength and was inversely associated with radial SSI (R-2 = 0.25, p = 0.018). In conclusion, chronic subclinical inflammation may negatively impact bone physiology in women with PCOS. Strategies focused on reducing abdominal adiposity and avoiding medications that increase inflammation may counter this effect.
C1 [Kalyan, Shirin; Kingwell, Elaine; Cote, Helene C. F.; Prior, Jerilynn C.] Univ British Columbia, Div Endocrinol, Dept Med, Ctr Menstrual Cycle & Ovulat Res, Vancouver, BC, Canada.
   [Kalyan, Shirin; Kingwell, Elaine; Cote, Helene C. F.; Prior, Jerilynn C.] Vancouver Coastal Hlth Res Inst, Vancouver, BC, Canada.
   [Kalyan, Shirin; Cote, Helene C. F.; Prior, Jerilynn C.] Womens Hlth Res Inst, Vancouver, BC, Canada.
   [Patel, Millan S.] Univ British Columbia, Deptartment Med Genet, Vancouver, BC, Canada.
   [Kingwell, Elaine] Univ British Columbia, Div Neurol, Dept Med, Vancouver, BC, Canada.
   [Cote, Helene C. F.] Univ British Columbia, Dept Pathol & Lab Med, Vancouver, BC, Canada.
   [Liu, Danmei] Univ British Columbia, Ctr Hip Hlth & Mobil, Vancouver, BC, Canada.
   [Prior, Jerilynn C.] Univ British Columbia, Sch Populat & Publ Hlth, Vancouver, BC, Canada.
C3 University of British Columbia; Vancouver Coastal Health Research
   Institute; University of British Columbia; University of British
   Columbia; University of British Columbia; University of British
   Columbia; University of British Columbia
RP Kalyan, S (corresponding author), Univ British Columbia, Div Endocrinol, Dept Med, Ctr Menstrual Cycle & Ovulat Res, Vancouver, BC, Canada.; Kalyan, S (corresponding author), Vancouver Coastal Hlth Res Inst, Vancouver, BC, Canada.
EM shirin.kalyan@ubc.ca
RI Kalyan, Shirin/HSA-6985-2023; Kingwell, Elaine/LWI-2687-2024; Cote,
   Helene/K-7896-2012; Kalyan, Shirin/E-2130-2011
OI /0000-0001-7061-6837; Kingwell, Elaine/0000-0002-1956-1700; Kalyan,
   Shirin/0000-0002-7332-2225
FU Canadian Institutes of Health Research (CIHR) [106644]
FX We thank Drs Sarah Charlesworth and Danielle Zhou for recruitment and
   data management. We also appreciate the contributions of Dr. Heather
   MacDonald (Department of Family Practice, University of British
   Columbia) to pQCT bone measures and Andy K.O. Wong (University Health
   Network) to pQCT muscle analysis and for critically assessing the
   manuscript. We sincerely appreciate the time and contribution of all the
   participants. The study was funded by a Bone Catalyst Grant (# 106644)
   from the Canadian Institutes of Health Research (CIHR).
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NR 40
TC 33
Z9 34
U1 0
U2 12
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD JUN 13
PY 2017
VL 7
AR 3432
DI 10.1038/s41598-017-03685-x
PG 8
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA EX3NV
UT WOS:000403140000103
PM 28611442
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Lappalainen, R
   Sairanen, E
   Järvelä, E
   Rantala, S
   Korpela, R
   Puttonen, S
   Kujala, UM
   Myllymäki, T
   Peuhkuri, K
   Mattila, E
   Kaipainen, K
   Ahtinen, A
   Karhunen, L
   Pihlajamäki, J
   Järnefelt, H
   Laitinen, J
   Kutinlahti, E
   Saarelma, O
   Ermes, M
   Kolehmainen, M
AF Lappalainen, Raimo
   Sairanen, Essi
   Jarvela, Elina
   Rantala, Sanni
   Korpela, Riitta
   Puttonen, Sampsa
   Kujala, Urho M.
   Myllymaki, Tero
   Peuhkuri, Katri
   Mattila, Elina
   Kaipainen, Kirsikka
   Ahtinen, Aino
   Karhunen, Leila
   Pihlajamaki, Jussi
   Jarnefelt, Heli
   Laitinen, Jaana
   Kutinlahti, Eija
   Saarelma, Osmo
   Ermes, Miikka
   Kolehmainen, Marjukka
TI The effectiveness and applicability of different lifestyle interventions
   for enhancing wellbeing: the study design for a randomized controlled
   trial for persons with metabolic syndrome risk factors and psychological
   distress
SO BMC PUBLIC HEALTH
LA English
DT Article
DE Lifestyle; Well-being; Obesity; Stress; Acceptance and Commitment
   Therapy; Cognitive behavioral therapy; Mobile application; Web based
   intervention; Technology aided interventions
ID COGNITIVE-BEHAVIOR THERAPY; COMMITMENT THERAPY; EATING COMPETENCE;
   PHYSICAL-ACTIVITY; PSYCHOMETRIC PROPERTIES; SELF-MANAGEMENT; ACCEPTANCE;
   INTERNET; HEALTH; MINDFULNESS
AB Background: Obesity and stress are among the most common lifestyle-related health problems. Most of the current disease prevention and management models are not satisfactorily cost-effective and hardly reach those who need them the most. Therefore, novel evidence-based controlled interventions are necessary to evaluate models for prevention and treatment based on self-management. This randomized controlled trial examines the effectiveness, applicability, and acceptability of different lifestyle interventions with individuals having symptoms of metabolic syndrome and psychological distress. The offered interventions are based on cognitive behavioral approaches, and are designed for enhancing general well-being and supporting personalized lifestyle changes.
   Methods/Design: 339 obese individuals reporting stress symptoms were recruited and randomized to either (1) a minimal contact web-guided Cognitive Behavioral Therapy-based (CBT) intervention including an approach of health assessment and coaching methods, (2) a mobile-guided intervention comprising of mindfulness, acceptance and value-based exercises, (3) a face-to-face group intervention using mindfulness, acceptance and value-based approach, or (4) a control group. The participants were measured three times during the study (pre = week 0, post = week 10, and follow-up = week 36). Psychological well-being, lifestyles and habits, eating behaviors, and user experiences were measured using online surveys. Laboratory measurements for physical well-being and general health were performed including e. g. liver function, thyroid glands, kidney function, blood lipids and glucose levels and body composition analysis. In addition, a 3-day ambulatory heart rate and 7-day movement data were collected for analyzing stress, recovery, physical activity, and sleep patterns. Food intake data were collected with a 48 -hour diet recall interview via telephone. Differences in the effects of the interventions would be examined using multiple-group modeling techniques, and effect-size calculations.
   Discussion: This study will provide additional knowledge about the effects of three low intensity interventions for improving general well-being among individuals with obesity and stress symptoms. The study will show effects of two technology guided self-help interventions as well as effect of an acceptance and value-based brief group intervention. Those who might benefit from the aforesaid interventions will increase knowledge base to better understand what mechanisms facilitate effects of the interventions.
C1 [Lappalainen, Raimo; Sairanen, Essi; Myllymaki, Tero] Univ Jyvaskyla, Dept Psychol, Jyvaskyla 40014, Finland.
   [Jarvela, Elina; Karhunen, Leila; Pihlajamaki, Jussi; Kolehmainen, Marjukka] Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland.
   [Rantala, Sanni; Korpela, Riitta; Peuhkuri, Katri] Univ Helsinki, Inst Biomed, Helsinki, Finland.
   [Puttonen, Sampsa; Jarnefelt, Heli; Laitinen, Jaana] Finnish Inst Occupat Hlth, Helsinki, Finland.
   [Kujala, Urho M.] Univ Jyvaskyla, Dept Hlth Sci, Jyvaskyla 40014, Finland.
   [Mattila, Elina; Kaipainen, Kirsikka; Ahtinen, Aino; Ermes, Miikka] VTT Tech Res Ctr Finland, Tampere, Finland.
   [Kutinlahti, Eija; Saarelma, Osmo] Duodecim Med Publicat Ltd, Helsinki, Finland.
C3 University of Jyvaskyla; University of Eastern Finland; University of
   Helsinki; Finnish Institute of Occupational Health; University of
   Jyvaskyla; VTT Technical Research Center Finland
RP Lappalainen, R (corresponding author), Univ Jyvaskyla, Dept Psychol, Ylistonmaentie 33,POB 35, Jyvaskyla 40014, Finland.
EM raimo.lappalainen@jyu.fi
RI Kolehmainen, Marjukka/JFS-1563-2023; Kujala, Urho/AAP-2547-2020
OI Pihlajamaki, Jussi/0000-0002-6241-6859; Mattila,
   Elina/0000-0001-7805-5982; Jarnefelt, Heli/0000-0002-3574-1453;
   Kaipainen, Kirsikka/0000-0002-7261-8868; Kujala,
   Urho/0000-0002-9262-1992; Jarvela-Reijonen, Elina/0000-0002-9346-3340;
   Korpela, Riitta/0000-0003-0337-9186; Sairanen, Essi/0000-0002-4499-644X;
   Puttonen, Sampsa/0000-0002-7796-6941; Kolehmainen,
   Marjukka/0000-0002-3770-2538
FU SalWe Research Programme for Mind and Body (Tekes - the Finnish Funding
   Agency for Technology and Innovation) [1104/10]
FX The study was supported by the SalWe Research Programme for Mind and
   Body (Tekes - the Finnish Funding Agency for Technology and Innovation
   grant 1104/10).
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NR 77
TC 32
Z9 33
U1 2
U2 71
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2458
J9 BMC PUBLIC HEALTH
JI BMC Public Health
PD APR 4
PY 2014
VL 14
AR 310
DI 10.1186/1471-2458-14-310
PG 16
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA AG5NO
UT WOS:000335465900001
PM 24708617
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Swiatkiewicz, I
   Di Somma, S
   De Fazio, L
   Mazzilli, V
   Taub, PR
AF Swiatkiewicz, Iwona
   Di Somma, Salvatore
   De Fazio, Ludovica
   Mazzilli, Valerio
   Taub, Pam R.
TI Effectiveness of Intensive Cardiac Rehabilitation in High-Risk Patients
   with Cardiovascular Disease in Real-World Practice
SO NUTRIENTS
LA English
DT Article
DE cardiovascular disease; cardiovascular risk factors; cardiometabolic
   risks; obesity; secondary prevention; lifestyle intervention; cardiac
   rehabilitation; outcomes; plant-based diet; specialized diet; coronary
   artery disease
ID RANDOMIZED CONTROLLED-TRIAL; CORONARY-HEART-DISEASE; SECONDARY
   PREVENTION; MYOCARDIAL-INFARCTION; EUROPEAN ASSOCIATION;
   CLINICAL-OUTCOMES; POSITION PAPER; BLOOD-PRESSURE; METAANALYSIS;
   EXERCISE
AB Structured lifestyle interventions through cardiac rehabilitation (CR) are critical to improving the outcome of patients with cardiovascular disease (CVD) and cardiometabolic risk factors. CR programs' variability in real-world practice may impact CR effects. This study evaluates intensive CR (ICR) and standard CR (SCR) programs for improving cardiometabolic, psychosocial, and clinical outcomes in high-risk CVD patients undergoing guideline-based therapies. Both programs provided lifestyle counseling and the same supervised exercise component. ICR additionally included a specialized plant-based diet, stress management, and social support. Changes in body weight (BW), low-density lipoprotein cholesterol (LDL-C), and exercise capacity (EC) were primary outcomes. A total of 314 patients (101 ICR and 213 SCR, aged 66 & PLUSMN; 13 years, 75% overweight/obese, 90% coronary artery disease, 29% heart failure, 54% non-optimal LDL-C, 43% depressive symptoms) were included. Adherence to ICR was 96% vs. 68% for SCR. Only ICR resulted in a decrease in BW (3.4%), LDL-C (11.3%), other atherogenic lipids, glycated hemoglobin, and systolic blood pressure. Both ICR and SCR increased EC (52.2% and 48.7%, respectively) and improved adiposity indices, diastolic blood pressure, cholesterol intake, depression, and quality of life, but more for ICR. Within 12.6 & PLUSMN; 4.8 months post-CR, major adverse cardiac events were less likely in the ICR than SCR group (11% vs. 17%), especially heart failure hospitalizations (2% vs. 8%). A comprehensive ICR enhanced by a plant-based diet and psychosocial management is feasible and effective for improving the outcomes in high-risk CVD patients in real-world practice.
C1 [Swiatkiewicz, Iwona; Taub, Pam R.] Univ Calif San Diego, Div Cardiovasc Med, La Jolla, CA 92037 USA.
   [Swiatkiewicz, Iwona] Nicolaus Copernicus Univ Torun, Dept Cardiol & Internal Med, Coll Med Bydgoszcz, PL-85094 Bydgoszcz, Poland.
   [Di Somma, Salvatore; De Fazio, Ludovica; Mazzilli, Valerio] Sapienza Univ Rome, Dept Med Surg Sci & Translat Med, I-00189 Rome, Italy.
C3 University of California System; University of California San Diego;
   Nicolaus Copernicus University; Ludwik Rydygier Collegium Medicum;
   Sapienza University Rome
RP Swiatkiewicz, I (corresponding author), Univ Calif San Diego, Div Cardiovasc Med, La Jolla, CA 92037 USA.; Swiatkiewicz, I (corresponding author), Nicolaus Copernicus Univ Torun, Dept Cardiol & Internal Med, Coll Med Bydgoszcz, PL-85094 Bydgoszcz, Poland.
EM iwona.swiatkiewicz@gmail.com; salvatore.disomma@uniroma1.it;
   defazio.1638451@studenti.uniroma1.it;
   mazzilli.1626463@studenti.uniroma1.it; ptaub@health.ucsd.edu
RI Swiatkiewicz, Iwona/H-4279-2014
OI Taub, Pam/0000-0002-0684-0655; DE FAZIO, LUDOVICA/0009-0000-8598-3381;
   Mazzilli, Valerio/0000-0001-6630-5104
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NR 63
TC 26
Z9 28
U1 0
U2 5
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD NOV
PY 2021
VL 13
IS 11
AR 3883
DI 10.3390/nu13113883
PG 19
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nutrition & Dietetics
GA XF3WP
UT WOS:000724004800001
PM 34836144
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Paquette, JS
   Rheaume, C
   Cordeau, P
   Moulin, JA
   Audet-Walsh, E
   Blanchette, V
   Drouin-Chartier, JP
   Toi, AK
   Tremblay, A
   Mougios, V
AF Paquette, Jean-Sebastien
   Rheaume, Caroline
   Cordeau, Pierre
   Moulin, Julie-Alexandra
   Audet-Walsh, Etienne
   Blanchette, Virginie
   Drouin-Chartier, Jean-Philippe
   Toi, Alfred-Kodjo
   Tremblay, Angelo
   Mougios, Vassilis
TI The Longevity Protein Klotho: A Promising Tool to Monitor Lifestyle
   Improvements
SO METABOLITES
LA English
DT Review
DE lifestyle medicine; klotho; biomarker; aging; health
ID MIDDLE-AGED ADULTS; ALCOHOL-CONSUMPTION; METABOLIC SYNDROME; SLEEP
   DURATION; CHRONIC STRESS; ALPHA-KLOTHO; BIOMARKERS; DISEASE; GENE;
   HEALTH
AB Aging is not a disease; it is a natural evolution of human physiology. Medical advances have extended our life expectancy, but chronic diseases and geriatric syndrome continue to affect the increasingly aging population. Yet modern medicine perpetuates an approach based on treatment rather than prevention and education. In order to help solve this ever-growing problem, a new discipline has emerged: lifestyle medicine. Nutrition, physical activity, stress management, restorative sleep, social connection, and avoidance of risky substances are the pillars on which lifestyle medicine is founded. The aim of this discipline is to increase healthspan and reduce the duration of morbidity by making changes to our lifestyle. In this review, we propose the use of klotho protein as a novel biomarker for lifestyle medicine in order to quantify and monitor the health status of individuals, as no integrative tool currently exists.
C1 [Paquette, Jean-Sebastien] Grp Med Famille Univ Nord Lanaudiere, Ctr Integrede Sante & Serv Sociaux Lanaudiere, Primary Care Res & Innovat Lab,Lab ARIMED, Joliette, PQ J6E 5X7, Canada.
   [Paquette, Jean-Sebastien; Rheaume, Caroline] Laval Univ, Fac Med, Dept Family Med & Emergency Med, Quebec City, PQ G1V 0A6, Canada.
   [Paquette, Jean-Sebastien; Rheaume, Caroline; Cordeau, Pierre; Moulin, Julie-Alexandra; Blanchette, Virginie; Toi, Alfred-Kodjo] Univ Laval, Vitam Res Ctr Sustainable Hlth, Quebec City, PQ G1V 0A6, Canada.
   [Audet-Walsh, Etienne] Univ Laval, Fac Med, Dept Med Mol, Quebec City, PQ G1V 0A6, Canada.
   [Blanchette, Virginie] Univ Quebec Trois Rivieres, Dept Human Kinet & Podiatr Med, Trois Rivieres G1V 0A6, PQ, Canada.
   [Drouin-Chartier, Jean-Philippe; Tremblay, Angelo] Laval Univ, Inst Nutr & Funct Foods INAF, NUTRISS Nutr Hlth & Soc Res Ctr, Quebec City, PQ G1V 0A6, Canada.
   [Drouin-Chartier, Jean-Philippe] Laval Univ, Fac Pharm, Quebec City, PQ G1V 0A6, Canada.
   [Tremblay, Angelo] Univ Laval, Fac Med, Dept Kinesiol, Quebec City, PQ G1V 0A6, Canada.
   [Tremblay, Angelo] Ctr Rech Inst Univ Cardiol & Pneumol Quebec IUCPQ, Quebec City, PQ G1V 4G5, Canada.
C3 Laval University; Laval University; Laval University; University of
   Quebec; University of Quebec Trois Rivieres; Laval University; Laval
   University; Laval University
RP Paquette, JS (corresponding author), Grp Med Famille Univ Nord Lanaudiere, Ctr Integrede Sante & Serv Sociaux Lanaudiere, Primary Care Res & Innovat Lab,Lab ARIMED, Joliette, PQ J6E 5X7, Canada.; Paquette, JS (corresponding author), Laval Univ, Fac Med, Dept Family Med & Emergency Med, Quebec City, PQ G1V 0A6, Canada.; Paquette, JS (corresponding author), Univ Laval, Vitam Res Ctr Sustainable Hlth, Quebec City, PQ G1V 0A6, Canada.
EM jspaquette.lab@gmail.com
RI Blanchette, Virginie/AHC-3512-2022; Paquette,
   Jean-Sebastien/Y-9736-2018; Rheaume, Caroline/GLS-9147-2022
OI Paquette, Jean-Sebastien/0000-0002-9524-6761; Audet-Walsh,
   Etienne/0000-0002-7710-8365; Rheaume, Caroline/0000-0002-1863-4410;
   Drouin-Chartier, Jean-Philippe/0000-0002-6733-4801; Blanchette,
   Virginie/0000-0002-5901-8964
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NR 114
TC 6
Z9 6
U1 2
U2 14
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2218-1989
J9 METABOLITES
JI Metabolites
PD NOV
PY 2023
VL 13
IS 11
AR 1157
DI 10.3390/metabo13111157
PG 16
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA AR8M1
UT WOS:001120277800001
PM 37999253
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Notarnicola, M
   Osella, AR
   Caruso, MG
   Pesole, PL
   Lippolis, A
   Tutino, V
   Bonfiglio, C
   De Nunzio, V
   Scavo, MP
   Mirizzi, A
   Franco, I
   Lippolis, T
   D'Alessandro, R
   Refolo, MG
   Messa, C
AF Notarnicola, Maria
   Osella, Alberto Ruben
   Caruso, Maria Gabriella
   Pesole, Pasqua Letizia
   Lippolis, Antonio
   Tutino, Valeria
   Bonfiglio, Caterina
   De Nunzio, Valentina
   Scavo, Maria Principia
   Mirizzi, Antonella
   Franco, Isabella
   Lippolis, Tamara
   D'Alessandro, Rosalba
   Refolo, Maria Grazia
   Messa, Caterina
TI Nonalcoholic Fatty Liver Disease: Focus on New Biomarkers and Lifestyle
   Interventions
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE NAFLD; fatty acids; exosomes; cytokeratins; lipid metabolism;
   Mediterranean diet; physical activity
ID INDUCED OXIDATIVE STRESS; HEPATIC STELLATE CELLS; ACID LIPASE ACTIVITY;
   EXTRACELLULAR VESICLES; PHYSICAL-ACTIVITY; GUT MICROBIOTA; CONFERS
   SUSCEPTIBILITY; CARDIOVASCULAR-DISEASE; INSULIN-RESISTANCE;
   LIPID-ACCUMULATION
AB Nonalcoholic fatty liver disease (NAFLD) is considered a hepatic manifestation of metabolic syndrome, characterized from pathological changes in lipid and carbohydrate metabolism. Its main characteristics are excessive lipid accumulation and oxidative stress, which create a lipotoxic environment in hepatocytes leading to liver injury. Recently, many studies have focused on the identification of the genetic and epigenetic modifications that also contribute to NAFLD pathogenesis and their prognostic implications. The present review is aimed to discuss on cellular and metabolic alterations associated with NAFLD, which can be helpful to identify new noninvasive biomarkers. The identification of accumulated lipids in the cell membranes, as well as circulating cytokeratins and exosomes, provides new insights in understanding of NAFLD. This review also suggests that lifestyle modifications remain the main prevention and/or treatment for NAFLD.
C1 [Notarnicola, Maria; Tutino, Valeria; De Nunzio, Valentina; Lippolis, Tamara] S de Bellis Res Hosp, Natl Inst Gastroenterol, Lab Nutr Biochem, I-70013 Castellana Grotte, BA, Italy.
   [Osella, Alberto Ruben; Bonfiglio, Caterina; Mirizzi, Antonella; Franco, Isabella] S de Bellis Res Hosp, Natl Inst Gastroenterol, Lab Epidemiol & Biostat, I-70013 Castellana Grotte, BA, Italy.
   [Caruso, Maria Gabriella] S de Bellis Res Hosp, Natl Inst Gastroenterol, Ambulatory Clin Nutr, I-70013 Castellana Grotte, BA, Italy.
   [Pesole, Pasqua Letizia; Lippolis, Antonio] S de Bellis Res Hosp, Natl Inst Gastroenterol, Clin Pathol Lab, I-70013 Castellana Grotte, BA, Italy.
   [Scavo, Maria Principia] S de Bellis Res Hosp, Natl Inst Gastroenterol, Lab Personalized Med, I-70013 Castellana Grotte, BA, Italy.
   [D'Alessandro, Rosalba; Refolo, Maria Grazia; Messa, Caterina] S de Bellis Res Hosp, Natl Inst Gastroenterol, Lab Cellular & Mol Biol, I-70013 Castellana Grotte, BA, Italy.
RP Notarnicola, M (corresponding author), S de Bellis Res Hosp, Natl Inst Gastroenterol, Lab Nutr Biochem, I-70013 Castellana Grotte, BA, Italy.
EM maria.notarnicola@irccsdebellis.it; ar.osella@irccsdebellis.it;
   gabriella.caruso@irccsdebellis.it; pesoleletizia@gmail.com;
   antonio.lippolis@irccsdebellis.it; valeria.tutino@irccsdebellis.it;
   catia.bonfiglio@irccsdebellis.it; valentinadx@hotmail.it;
   maria.scavo@irccsdebellis.it; antonella.mirizzi@irccsdebellis.it;
   isabella.franco@irccsdebellis.it; lippolis.tamara@gmail.com;
   rosalba.dalessandro@irccsdebellis.it; maria.refolo@irccsdebellis.it;
   caterina.messa@irccsdebellis.it
RI D'Alessandro, Rosalba/J-2351-2018; Scavo, Maria/AAR-6713-2020
OI Bonfiglio, Caterina/0000-0002-8650-348X; D'Alessandro,
   Rosalba/0000-0001-9604-366X; Lippolis, Tamara/0000-0001-8983-0331;
   Caruso, Maria Gabriella/0000-0003-4518-6307; pesole, pasqua
   letizia/0000-0003-4675-2075
FU  [700/2020];  [15]
FX This work was supported by RC2020-2021, Prog. Nffi 15 (DDG. n.
   700/2020).
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NR 147
TC 23
Z9 23
U1 2
U2 31
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD APR
PY 2021
VL 22
IS 8
AR 3899
DI 10.3390/ijms22083899
PG 17
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA RT3CR
UT WOS:000644340800001
PM 33918878
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Kolodziej, F
   O'Halloran, KD
AF Kolodziej, Filip
   O'Halloran, Ken D.
TI Re-Evaluating the Oxidative Phenotype: Can Endurance Exercise Save the
   Western World?
SO ANTIOXIDANTS
LA English
DT Review
DE oxidative stress; endurance exercise; metabolic disease; oxidative
   phenotype
AB Mitochondria are popularly called the "powerhouses" of the cell. They promote energy metabolism through the tricarboxylic acid (TCA) cycle and oxidative phosphorylation, which in contrast to cytosolic glycolysis are oxygen-dependent and significantly more substrate efficient. That is, mitochondrial metabolism provides substantially more cellular energy currency (ATP) per macronutrient metabolised. Enhancement of mitochondrial density and metabolism are associated with endurance training, which allows for the attainment of high relative VO2 max values. However, the sedentary lifestyle and diet currently predominant in the Western world lead to mitochondrial dysfunction. Underdeveloped mitochondrial metabolism leads to nutrient-induced reducing pressure caused by energy surplus, as reduced nicotinamide adenine dinucleotide (NADH)-mediated high electron flow at rest leads to "electron leak" and a chronic generation of superoxide radicals (O-2(-)). Chronic overload of these reactive oxygen species (ROS) damages cell components such as DNA, cell membranes, and proteins. Counterintuitively, transiently generated ROS during exercise contributes to adaptive reduction-oxidation (REDOX) signalling through the process of cellular hormesis or "oxidative eustress" defined by Helmut Sies. However, the unaccustomed, chronic oxidative stress is central to the leading causes of mortality in the 21st century-metabolic syndrome and the associated cardiovascular comorbidities. The endurance exercise training that improves mitochondrial capacity and the protective antioxidant cellular system emerges as a universal intervention for mitochondrial dysfunction and resultant comorbidities. Furthermore, exercise might also be a solution to prevent ageing-related degenerative diseases, which are caused by impaired mitochondrial recycling. This review aims to break down the metabolic components of exercise and how they translate to athletic versus metabolically diseased phenotypes. We outline a reciprocal relationship between oxidative metabolism and inflammation, as well as hypoxia. We highlight the importance of oxidative stress for metabolic and antioxidant adaptation. We discuss the relevance of lactate as an indicator of critical exercise intensity, and inferring from its relationship with hypoxia, we suggest the most appropriate mode of exercise for the case of a lost oxidative identity in metabolically inflexible patients. Finally, we propose a reciprocal signalling model that establishes a healthy balance between the glycolytic/proliferative and oxidative/prolonged-ageing phenotypes. This model is malleable to adaptation with oxidative stress in exercise but is also susceptible to maladaptation associated with chronic oxidative stress in disease. Furthermore, mutations of components involved in the transcriptional regulatory mechanisms of mitochondrial metabolism may lead to the development of a cancerous phenotype, which progressively presents as one of the main causes of death, alongside the metabolic syndrome.
C1 [Kolodziej, Filip; O'Halloran, Ken D.] Univ Coll Cork, Coll Med & Hlth, Sch Med, Dept Physiol, Cork T12 XF62, Ireland.
C3 University College Cork
RP Kolodziej, F (corresponding author), Univ Coll Cork, Coll Med & Hlth, Sch Med, Dept Physiol, Cork T12 XF62, Ireland.
EM 116333553@umail.ucc.ie; K.OHalloran@ucc.ie
OI Kolodziej, Filip/0000-0002-5575-2037
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NR 308
TC 15
Z9 16
U1 0
U2 18
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD APR
PY 2021
VL 10
IS 4
AR 609
DI 10.3390/antiox10040609
PG 35
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA RQ9IN
UT WOS:000642725400001
PM 33921022
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Wu, JY
   Huang, YX
   Zhan, C
   Chen, LL
   Lin, ZM
   Song, Z
AF Wu, Jinyan
   Huang, Yaxian
   Zhan, Chi
   Chen, Lingling
   Lin, Zhengmei
   Song, Zhi
TI Thioredoxin-1 promotes the restoration of alveolar bone in periodontitis
   with diabetes
SO ISCIENCE
LA English
DT Article
ID OXIDATIVE STRESS; OSTEOGENIC DIFFERENTIATION; METABOLIC SYNDROME;
   DISEASES; RISK; OVEREXPRESSION; THERAPY; HEALTH
AB Treatment of periodontitis in people with diabetes remains challenging. The present study aimed to investigate the therapeutic potential of thioredoxin-1 (TRX1) in periodontitis with diabetes, as well as its role in modulating osteogenic differentiation. Our findings indicated that the production of reactive oxygen species (ROS) was elevated, while the expression of TRX1 was significantly reduced in the periodontal tissues of periodontitis mice with diabetes. Furthermore, knockdown of TRX1 in periodontal ligament stem cells (PDLSCs) resulted in the inhibition of osteogenic differentiation through disrupting Wnt/b-catenin signaling. However, this inhibition was restored upon administration of recombinant human TRX1 (rhTRX1). Importantly, rhTRX1 treatment decreased ROS generation, activated Wnt/b-catenin signal pathway and considerably promoted the alveolar bone repair of periodontitis mice with diabetes. These findings highlighted the crucial protective role of TRX1 in periodontitis with diabetes and suggested that it may serve as a potential therapeutic target for refractory periodontitis associated with oxidative stress.
C1 [Wu, Jinyan; Huang, Yaxian; Zhan, Chi; Chen, Lingling; Lin, Zhengmei; Song, Zhi] Sun Yat sen Univ, Hosp Stomatol, Guanghua Sch Stomatol, Guangdong Prov Key Lab Stomatol, Guangzhou 510055, Guangdong, Peoples R China.
   [Wu, Jinyan] Kunming Med Univ, Sch & Hosp Stomatol, Yunnan Key Lab Stomatol, Kunming 650106, Peoples R China.
C3 Sun Yat Sen University; Kunming Medical University
RP Lin, ZM; Song, Z (corresponding author), Sun Yat sen Univ, Hosp Stomatol, Guanghua Sch Stomatol, Guangdong Prov Key Lab Stomatol, Guangzhou 510055, Guangdong, Peoples R China.
EM linzhm@mail.sysu.edu.cn; songzh@mail.sysu.edu.cn
RI Chen, Lingling/HNQ-1348-2023; JINYAN, WU/IQR-4321-2023
OI Wu, Jinyan/0000-0001-7346-8542
FU National Science Foundation of China [81873713, 82170939]; Natural
   Science Foundation of Guangdong Province, China [2019A1515010967]
FX The authors are grateful to Zongshan Shen from Sun Yat-Sen University
   for his valuable input in discussing the study idea and analyzing the
   underlying reasons for the challenges encountered during the
   experimental process. This work was supported by grants from the
   National Science Foundation of China (Grant Nos. 81873713, 82170939) and
   the Natural Science Foundation of Guangdong Province, China (Grant No.
   2019A1515010967).
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NR 54
TC 4
Z9 4
U1 2
U2 10
PU CELL PRESS
PI CAMBRIDGE
PA 50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA
EI 2589-0042
J9 ISCIENCE
JI iScience
PD SEP 15
PY 2023
VL 26
IS 9
AR 107618
DI 10.1016/j.isci.2023.107618
EA AUG 2023
PG 19
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA R8NR6
UT WOS:001066874500001
PM 37664614
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Zhang, CX
   Wang, HY
   Yin, L
   Mao, YY
   Zhou, W
AF Zhang, Chen-xing
   Wang, Hui-yu
   Yin, Lei
   Mao, You-ying
   Zhou, Wei
TI Immunometabolism in the pathogenesis of systemic lupus erythematosus
SO JOURNAL OF TRANSLATIONAL AUTOIMMUNITY
LA English
DT Review
DE Systemic lupus erythematosus (SLE); Metabolic programs; Immune response;
   Pathogenesis
ID CD4(+) T-CELLS; FATTY-ACID OXIDATION; METABOLIC SYNDROME; MAMMALIAN
   TARGET; DENDRITIC CELLS; B-CELLS; MACROPHAGE ACTIVATION; SIGNALING
   PATHWAY; DNA METHYLATION; ORGAN DAMAGE
AB Systemic lupus erythematosus (SLE) is a typical autoimmune disease characterized by chronic inflammation and pathogenic auto-antibodies. Apart from B cells, dysregulation of other immune cells also plays an essential role in the pathogenesis and development of the disease including CD4(+)T cells, dendritic cells, macrophages and neutrophils. Since metabolic programs control immune cell fate and function, they are critical checkpoints in an effective immune response and are involved in the etiology of autoimmune disease. In addition, mitochondria and oxidative stress are both involved in cellular metabolism and is also essential in immune response. In this review, apart from the disturbed immune system, we will discuss mitochondrial dysfunction, oxidative stress, abnormal metabolism (including glucose, lipid and amino acid metabolism) of immune cells as well as epigenetic control of metabolism reprogramming to elucidate the underlying pathogenic mechanisms of systemic lupus erythematosus.
C1 [Zhang, Chen-xing; Yin, Lei; Mao, You-ying; Zhou, Wei] Shanghai Jiao Tong Univ, Shanghai Childrens Med Ctr, Dept Nephrol, Sch Med, Shanghai 200127, Peoples R China.
   [Wang, Hui-yu] Univ Munster, Inst Physiol Chem & Pathobiochem, D-48149 Munster, Germany.
C3 Shanghai Jiao Tong University; University of Munster
RP Zhou, W (corresponding author), 1678 Dongfang Rd, Shanghai, Peoples R China.
EM zwqq121@sina.com
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NR 143
TC 24
Z9 26
U1 0
U2 12
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2589-9090
J9 J TRANSL AUTOIMMUN
JI J. Transl. Autoimmun.
PY 2020
VL 3
AR 100046
DI 10.1016/j.jtauto.2020.100046
PG 10
WC Immunology
WE Emerging Sources Citation Index (ESCI)
SC Immunology
GA SP8JM
UT WOS:000659909400023
PM 32743527
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Dabravolski, SA
   Bezsonov, EE
   Baig, MS
   Popkova, TV
   Nedosugova, LV
   Starodubova, AV
   Orekhov, AN
AF Dabravolski, Siarhei A.
   Bezsonov, Evgeny E.
   Baig, Mirza S.
   Popkova, Tatyana V.
   Nedosugova, Ludmila V.
   Starodubova, Antonina V.
   Orekhov, Alexander N.
TI Mitochondrial Mutations and Genetic Factors Determining NAFLD Risk
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE NAFLD; NASH; chronic inflammation; fibrosis; mitophagy; mitochondrial
   dysfunction; mitochondrial mutations; oxidative stress; SNPs
ID FATTY LIVER-DISEASE; NONALCOHOLIC STEATOHEPATITIS; NLRP3 INFLAMMASOME;
   LIPID DROPLETS; THERAPEUTIC TARGET; OXIDATIVE STRESS; TRIB1 RS17321515;
   PNPLA3 VARIANT; POLYMORPHISM; ASSOCIATION
AB NAFLD (non-alcoholic fatty liver disease) is a widespread liver disease that is often linked with other life-threatening ailments (metabolic syndrome, insulin resistance, diabetes, cardiovascular disease, atherosclerosis, obesity, and others) and canprogress to more severe forms, such as NASH (non-alcoholic steatohepatitis), cirrhosis, and HCC (hepatocellular carcinoma). In this review, we summarized and analyzed data about single nucleotide polymorphism sites, identified in genes related to NAFLD development and progression. Additionally, the causative role of mitochondrial mutations and mitophagy malfunctions in NAFLD is discussed. The role of mitochondria-related metabolites of the urea cycle as a new non-invasive NAFLD biomarker is discussed. While mitochondria DNA mutations and SNPs (single nucleotide polymorphisms) canbe used as effective diagnostic markers and target for treatments, age and ethnic specificity should be taken into account.
C1 [Dabravolski, Siarhei A.] Vitebsk State Acad Vet Med UO VGAVM, Dept Clin Diagnost, 7-11 Dovatora Str, Vitebsk 210026, BELARUS.
   [Bezsonov, Evgeny E.; Orekhov, Alexander N.] Inst Human Morphol, Lab Cellular & Mol Pathol Cardiovasc Syst, 3 Tsyurupa St, Moscow 117418, Russia.
   [Bezsonov, Evgeny E.; Orekhov, Alexander N.] Inst Gen Pathol & Pathophysiol, Lab Angiopathol, 8 Baltiyskaya St, Moscow 125315, Russia.
   [Baig, Mirza S.] Indian Inst Technol Indore IITI, Dept Biosci & Biomed Engn BSBE, Simrol 453552, India.
   [Popkova, Tatyana V.] VA Nasonova Inst Rheumatol, 34A Kashirskoye Shosse, Moscow 115522, Russia.
   [Nedosugova, Ludmila V.] Sechenov Univ, IM Sechenov First Moscow State Med Univ, 8-2 Trubenskaya St, Moscow 119991, Russia.
   [Starodubova, Antonina V.] Fed Res Ctr Nutr Biotechnol & Food Safety, 2-14 Ustinsky Passage, Moscow 109240, Russia.
   [Starodubova, Antonina V.] Pirogov Russian Natl Res Med Univ, 1 Ostrovitianov St, Moscow 117997, Russia.
C3 Russian Academy of Medical Sciences; Research Institute of Human
   Morphology; Russian Academy of Medical Sciences; Institute of General
   Pathology & Pathophysiology, RAMS; Indian Institute of Technology System
   (IIT System); Indian Institute of Technology (IIT) - Indore; Sechenov
   First Moscow State Medical University; Federal Research Center of
   Nutrition, Biotechnology & Food Safety; Pirogov Russian National
   Research Medical University
RP Dabravolski, SA (corresponding author), Vitebsk State Acad Vet Med UO VGAVM, Dept Clin Diagnost, 7-11 Dovatora Str, Vitebsk 210026, BELARUS.
EM siarhei.dabravolski@vsavm.by; evgeny.bezsonov@gmail.com;
   msb.iit@iiti.ac.in; popkovatv@mail.ru; profmila@mail.ru;
   avs.ion@yandex.ru; a.h.opexob@gmail.com
RI Tatyana, Popkova/T-6054-2017; Baig, Mirza/S-8447-2019; Bezsonov,
   Evgeny/AAL-1982-2021; Dabravolski, Siarhei/E-8303-2015; Starodubova,
   Antonina/F-7697-2017
OI Dabravolski, Siarhei/0000-0002-0547-6310; Starodubova,
   Antonina/0000-0001-9262-9233; Bezsonov, Evgeny/0000-0002-9382-8338;
   Orekhov, Alexander/0000-0002-3318-4681
FU Russian Science Foundation [18-15-00254]; Russian Science Foundation
   [21-15-28003] Funding Source: Russian Science Foundation
FX This work was supported by the Russian Science Foundation (Grant
   #18-15-00254).
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NR 225
TC 32
Z9 35
U1 1
U2 32
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD MAY
PY 2021
VL 22
IS 9
AR 4459
DI 10.3390/ijms22094459
PG 30
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA SC0IA
UT WOS:000650365400001
PM 33923295
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Qi, ZG
   Xie, ML
AF Qi, Zhigang
   Xie, Meilin
TI Research Progress on Pathogenesis of Obesity-Induced Insulin Resistance
   and Its Therapeutic Targets: PPARα/γ
SO CURRENT SIGNAL TRANSDUCTION THERAPY
LA English
DT Review
DE obesity; insulin resistance; PPAR alpha/gamma
ID FATTY-ACID OXIDATION; NF-KAPPA-B; ACTIVATED PROTEIN-KINASE; BETA-CELL
   DYSFUNCTION; HUMAN SKELETAL-MUSCLE; METABOLIC SYNDROME; ADIPOSE-TISSUE;
   GLOBULAR ADIPONECTIN; GLUCOSE-HOMEOSTASIS; MITOCHONDRIAL DYSFUNCTION
AB Insulin resistance (IR) is defined as a decreased response of peripheral tissues to insulin. It is a common cause of cardiovascular and hepatic diseases, and often precedes the onset of hyperglycemia and predicts the development of type 2 diabetes. Free fatty acids (FFA), inflammation and oxidative stress play key roles in the development and/or progression of IR induced by obesity. Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear hormone receptor superfamily; PPAR agonists can improve IR by regulating glucose and lipid metabolisms, and by inhibiting inflammatory and oxidative stress responses. In the article, we will review the pathogenesis of obesity-induced IR, its therapeutic targets: PPAR alpha/gamma, and discuss the signal transduction pathways through which these drugs exert therapeutic effects.
C1 [Qi, Zhigang; Xie, Meilin] Soochow Univ, Coll Med, Dept Pharmacol, Suzhou 215123, Jiangsu, Peoples R China.
C3 Soochow University - China
RP Xie, ML (corresponding author), Soochow Univ, Coll Med, Dept Pharmacol, Suzhou 215123, Jiangsu, Peoples R China.
EM xiemeilin@suda.edu.cn
FU Science and Technology Funds of Suzhou City [SWG0903]; Jiangsu Province,
   China [BE2008642]
FX This work was supported by grants from the Science and Technology Funds
   of Suzhou City (No. SWG0903) and Jiangsu Province (No. BE2008642),
   China.
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NR 84
TC 1
Z9 1
U1 0
U2 15
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1574-3624
EI 2212-389X
J9 CURR SIGNAL TRANSD T
JI Curr. Signal Transduct. Ther.
PD MAY
PY 2012
VL 7
IS 2
BP 177
EP 184
DI 10.2174/157436212800376717
PG 8
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 944IC
UT WOS:000304191700011
DA 2025-06-11
ER

PT J
AU Luong, N
   Davies, CR
   Wessells, RJ
   Graham, SM
   King, MT
   Veech, R
   Bodmer, R
   Oldham, SM
AF Luong, Nancy
   Davies, Claire R.
   Wessells, Robert J.
   Graham, Suzanne M.
   King, M. Todd
   Veech, Richard
   Bodmer, Rolf
   Oldham, Sean M.
TI Activated FOXO-mediated insulin resistance is blocked by reduction of
   TOR activity
SO CELL METABOLISM
LA English
DT Article
ID ELEGANS LIFE-SPAN; MAMMALIAN TARGET; PROTEIN-KINASE; CELL-GROWTH;
   RECEPTOR SUBSTRATE-1; DROSOPHILA HOMOLOG; STRESS RESISTANCE;
   SKELETAL-MUSCLE; RAPAMYCIN TOR; METABOLISM
AB Reducing insulin/IGF signaling allows for organismal survival during periods of inhospitable conditions by regulating the diapause state, whereby the organism stockpiles lipids, reduces fertility, increases stress resistance, and has an increased lifespan. The Target of Rapamycin (TOR) responds to changes in growth factors, amino acids, oxygen tension, and energy status; however, it is unclear how TOR contributes to physiological homeostasis and disease conditions. Here, we show that reducing the function of Drosophila TOR results in decreased lipid stores and glucose levels. Importantly, this reduction of dTOR activity blocks the insulin resistance and metabolic syndrome phenotypes associated with increased activity of the insulin responsive transcription factor, dFOXO. Reduction in dTOR function also protects against age-dependent decline in heart function and increases longevity. Thus, the regulation of dTOR activity may be an ancient "systems biological" means of regulating metabolism and senescence, that has important evolutionary, physiological, and clinical implications.
C1 Neurosci & Aging Ctr, Burnham Inst Med Res, Canc Res Ctr, La Jolla, CA 92037 USA.
   NIAAA, NIH, Rockville, MD 20895 USA.
C3 Sanford Burnham Prebys Medical Discovery Institute; National Institutes
   of Health (NIH) - USA; NIH National Institute on Alcohol Abuse &
   Alcoholism (NIAAA)
RP Oldham, SM (corresponding author), Neurosci & Aging Ctr, Burnham Inst Med Res, Canc Res Ctr, 10901 N Torrey Pines Rd, La Jolla, CA 92037 USA.
EM soldham@burnham.org
RI Wessells, Robert/AAG-3406-2020
OI Wessells, Robert/0000-0002-4516-3183
FU NHLBI NIH HHS [HL84949] Funding Source: Medline
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NR 93
TC 142
Z9 165
U1 1
U2 32
PU CELL PRESS
PI CAMBRIDGE
PA 50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA
SN 1550-4131
EI 1932-7420
J9 CELL METAB
JI Cell Metab.
PD AUG
PY 2006
VL 4
IS 2
BP 133
EP 142
DI 10.1016/j.cmet.2006.05.013
PG 10
WC Cell Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Endocrinology & Metabolism
GA 071ZY
UT WOS:000239643600007
PM 16890541
OA Bronze
DA 2025-06-11
ER

PT J
AU Mook, S
   Halkes, CJM
   Bilecen, S
   Cabezas, MC
AF Mook, S
   Halkes, CJM
   Bilecen, S
   Cabezas, MC
TI In vivo regulation of plasma free fatty acids in insulin resistance
SO METABOLISM-CLINICAL AND EXPERIMENTAL
LA English
DT Article
ID HORMONE-SENSITIVE LIPASE; ADIPOSE-TISSUE LIPOLYSIS; FAMILIAL COMBINED
   HYPERLIPIDEMIA; LIPOPROTEIN-LIPASE; SKELETAL-MUSCLE; ADIPOCYTE;
   SUPPRESSION; PERILIPIN; GLUCOSE; PATHOGENESIS
AB Elevated plasma free fatty acid (FFA) concentrations as seen in obesity, insulin resistance, and type 2 diabetes are partly caused by impaired inhibition of intracellular lipolysis in adipose tissue, and this is considered to be part of the insulin resistance syndrome (IRS). Based on predicted insulin resistance at the level of intracellular lipolysis, patients with the IRS would loose weight by disinhibited lipolysis. Since this is not the case in clinical practice, impaired stimulation of intracellular lipolysis must also play a role. We studied acute plasma FFA changes, representing stimulation and inhibition of intracellular adipose tissue lipolysis, in obese patients with IRS and in healthy controls. Thirteen insulin-resistant (IR) subjects (7 men and women) and 10 controls (6 men and 4 women) underwent a mental stress test (20 minutes) preceded by 60 minutes of rest. After mental stress, an oral glucose tolerance test (OGTT) was performed. Baseline FFA levels were higher in IR patients compared to controls (0.59 +/- 0.06 and 0.31 +/- 0.06 mmol/L, respectively; P = .004). During the 20 minutes of mental stress, FFAs increased significantly in IR subjects from 0.55 +/- 0.07 to 0.67 +/- 0.07 mmol/L (P<.001) and from 0.21 +/- 0.04 to 0.36 +/- 0.07 mmol/L in controls (P = .001). Although the absolute change of plasma FFA was not different, the relative increase was lower in IR subjects (28% +/- 7%) compared to controls (89 +/- 24%; P = .02). Despite the more pronounced mean maximal insulin concentration during the OGTT in IR subjects compared to controls (600.0 +/- 126.6 pmol/L and 208.1 +/- 30.0 pmol/L, respectively), the relative decrease of FFAs was lower in IR subjects (11% +/- 5% v 36% +/- 11% in controls after 30 minutes; P = .04). In conclusion, our study shows impaired acute responses of plasma FFAs upon stimulation by mental stress and inhibition by endogenous insulin in insulin resistance in vivo. The presence of both defects helps to understand weight maintenance in insulin resistance. (C) 2004 Elsevier Inc. All rights reserved.
C1 Univ Utrecht, Med Ctr, Dept Internal Med F02126, NL-3508 GA Utrecht, Netherlands.
C3 Utrecht University
RP Univ Utrecht, Med Ctr, Dept Internal Med F02126, POB 85500, NL-3508 GA Utrecht, Netherlands.
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NR 36
TC 47
Z9 49
U1 0
U2 5
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0026-0495
EI 1532-8600
J9 METABOLISM
JI Metab.-Clin. Exp.
PD SEP
PY 2004
VL 53
IS 9
BP 1197
EP 1201
DI 10.1016/j.metabol.2004.02.023
PG 5
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 856LU
UT WOS:000224047500019
PM 15334384
DA 2025-06-11
ER

PT J
AU Noll, C
   Kandiah, J
   Moroy, G
   Gu, YC
   Dairou, J
   Janel, N
AF Noll, Christophe
   Kandiah, Janany
   Moroy, Gautier
   Gu, Yuchen
   Dairou, Julien
   Janel, Nathalie
TI Catechins as a Potential Dietary Supplementation in Prevention of
   Comorbidities Linked with Down Syndrome
SO NUTRIENTS
LA English
DT Review
DE catechins; trisomy 21; Alzheimer's disease; metabolic syndrome; Dyrk1A
ID ENDOPLASMIC-RETICULUM STRESS; GREEN TEA CATECHINS; HIGH-FAT DIET;
   ALZHEIMERS-DISEASE; INSULIN-RESISTANCE; OXIDATIVE STRESS;
   BLOOD-PRESSURE; AMYLOID-BETA; CELL-DEATH; COGNITIVE IMPAIRMENT
AB Plant-derived polyphenols flavonoids are increasingly being recognized for their medicinal potential. These bioactive compounds derived from plants are gaining more interest in ameliorating adverse health risks because of their low toxicity and few side effects. Among them, therapeutic approaches demonstrated the efficacy of catechins, a major group of flavonoids, in reverting several aspects of Down syndrome, the most common genomic disorder that causes intellectual disability. Down syndrome is characterized by increased incidence of developing Alzheimer's disease, obesity, and subsequent metabolic disorders. In this focused review, we examine the main effects of catechins on comorbidities linked with Down syndrome. We also provide evidence of catechin effects on DYRK1A, a dosage-sensitive gene encoding a protein kinase involved in brain defects and metabolic disease associated with Down syndrome.
C1 [Noll, Christophe] Univ Sherbrooke, Ctr Rech CHUS, Dept Med, Div Endocrinol, Sherbrooke, PQ J1K 2R1, Canada.
   [Kandiah, Janany; Gu, Yuchen; Janel, Nathalie] Univ Paris Cite, Unite Biol Fonct & Adaptat, UMR CNRS 8251, F-75013 Paris, France.
   [Moroy, Gautier] Univ Paris Cite, Unite Biol Fonct & Adaptat, INSERM CNRS, F-75013 Paris, France.
   [Dairou, Julien] Univ Paris Cite, Lab Chim & Biochim Pharmacol & Toxicol, UMR CNRS 8601, F-75006 Paris, France.
C3 University of Sherbrooke; Centre National de la Recherche Scientifique
   (CNRS); CNRS - National Institute for Biology (INSB); Universite Paris
   Cite; Institut National de la Sante et de la Recherche Medicale
   (Inserm); Universite Paris Cite; Centre National de la Recherche
   Scientifique (CNRS); CNRS - Institute of Chemistry (INC); Universite
   Paris Cite
RP Janel, N (corresponding author), Univ Paris Cite, Unite Biol Fonct & Adaptat, UMR CNRS 8251, F-75013 Paris, France.
EM christophe.noll@usherbrooke.ca; kdjanany@gmail.com;
   gautier.moroy@u-paris.fr; guyuchen0509@hotmail.com;
   julien.dairou@u-paris.fr; nathalie.janel@u-paris.fr
RI Dairou, julien/HKE-3126-2023; Moroy, Gautier/AAT-1608-2020
OI Moroy, Gautier/0000-0002-8973-0477; Dairou, Julien/0000-0003-1767-0572;
   , yuch/0000-0003-3188-2264; Janel, Nathalie/0000-0002-4746-8941; Noll,
   Christophe/0000-0002-2874-2060
FU Fondation Jerome Lejeune [2017a-1634]; French state funds through the
   "Agence Nationale de la Recherche" program [ANR-18-CE16-0020 DYRKDOWN]
FX This work was supported by the Fondation Jerome Lejeune (grant number
   2017a-1634) and the French state funds through the "Agence Nationale de
   la Recherche" program (ANR-18-CE16-0020 DYRKDOWN).
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NR 168
TC 8
Z9 8
U1 0
U2 8
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD MAY
PY 2022
VL 14
IS 10
AR 2039
DI 10.3390/nu14102039
PG 22
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 1R3AU
UT WOS:000803246600001
PM 35631180
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Ferranti, EP
   Dunbar, SB
   Higgins, M
   Dai, J
   Ziegler, TR
   Frediani, JK
   Reilly, C
   Brigham, KL
AF Ferranti, Erin Poe
   Dunbar, Sandra B.
   Higgins, Melinda
   Dai, Jun
   Ziegler, Thomas R.
   Frediani, Jennifer K.
   Reilly, Carolyn
   Brigham, Kenneth L.
TI Psychosocial factors associated with diet quality in a working adult
   population
SO RESEARCH IN NURSING & HEALTH
LA English
DT Article
DE diet quality; diet patterns; AHEI; DASH; Mediterranean diet;
   psychosocial
ID CORONARY-HEART-DISEASE; FAMILY ASSESSMENT DEVICE; DASH EATING PLAN; STOP
   HYPERTENSION; VEGETABLE CONSUMPTION; MEDITERRANEAN DIET; METABOLIC
   SYNDROME; COLORECTAL-CANCER; PHYSICAL-ACTIVITY; PERCEIVED STRESS
AB The associations between specific intra- and inter-personal psychosocial factors and dietary patterns were explored in a healthy, working adult sample of university and health center employees (N=640) who were enrolled in a prospective predictive health study. Participants had a mean age of 48 (SD=11) years and were 67% women and 30% minority. Baseline psychosocial measures of perceived stress, depressive symptoms, social support, and family functioning were examined for their relationships with three diet quality indicesAHEI, DASH, and the Mediterranean. Dietary intake was of moderate quality in this high-income, well-educated, psychosocially healthy population. Social support was positively associated with better diet quality for all three indices (p<.01). Further research should focus on socio-environmental factors associated with diet quality. (c) 2013 Wiley Periodicals, Inc. Res Nurs Health 36:242256, 2013
C1 [Ferranti, Erin Poe; Dunbar, Sandra B.; Higgins, Melinda; Reilly, Carolyn] Emory Univ, Nell Hodgson Woodruff Sch Nursing, Atlanta, GA 30322 USA.
   [Dai, Jun] Indiana Univ, Dept Appl Hlth Sci, Bloomington, IN 47405 USA.
   [Ziegler, Thomas R.; Frediani, Jennifer K.] Emory Univ, Sch Med, Atlanta, GA 30322 USA.
   [Brigham, Kenneth L.] Emory Univ, Predict Hlth Inst, Atlanta, GA 30322 USA.
C3 Emory University; Indiana University System; Indiana University
   Bloomington; Emory University; Emory University
RP Ferranti, EP (corresponding author), Emory Univ, Nell Hodgson Woodruff Sch Nursing, 1520 Clifton Rd NE, Atlanta, GA 30322 USA.
RI Reilly, Carolyn/AGH-4208-2022; Frediani, Jennifer/GZL-2734-2022;
   Higgins, Melinda/B-6459-2013
OI Reilly, Carolyn/0000-0003-1641-1747; Higgins,
   Melinda/0000-0001-6579-5885; Frediani, Jennifer/0000-0002-4634-0591;
   Dai, Jun/0000-0001-7930-2885
FU TL1 grant [TR000456]; National Center for Advancing Translational
   Sciences of the National Institutes of Health [UL1TR000454]; CF
   Foundation, Inc.; Emory University
FX Supported by a TL1 grant (TR000456) and the National Center for
   Advancing Translational Sciences of the National Institutes of Health
   under Award Number UL1TR000454. The content is solely the responsibility
   of the authors and does not necessarily represent the official views of
   the National Institutes of Health. The Center for Health Discovery and
   Well Being Study (CHDWB) is supported by the CF Foundation, Inc., and
   Emory University. Acknowledgement of editorial assistance by Dr. Bonnie
   Jennings.
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NR 74
TC 35
Z9 45
U1 0
U2 29
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0160-6891
EI 1098-240X
J9 RES NURS HEALTH
JI Res. Nurs. Health
PD JUN
PY 2013
VL 36
IS 3
BP 242
EP 256
DI 10.1002/nur.21532
PG 15
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA 149UF
UT WOS:000319346200003
PM 23408456
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Godisela, KK
   Reddy, SS
   Reddy, PY
   Kumar, CU
   Reddy, VS
   Ayyagari, R
   Reddy, GB
AF Godisela, Kishore K.
   Reddy, Singareddy Sreenivasa
   Reddy, P. Yadagiri
   Kumar, Ch Uday
   Reddy, V. Sudhakar
   Ayyagari, Radha
   Reddy, G. Bhanuprakash
TI Role of sorbitol-mediated cellular stress response in obesity-associated
   retinal degeneration
SO ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
LA English
DT Article
DE Electroretinogram; ER stress; Insulin receptor; Retinal degeneration
ID ACTIVATED PROTEIN-KINASE; ENDOPLASMIC-RETICULUM STRESS;
   UBIQUITIN-PROTEASOME SYSTEM; RAT MODEL; METABOLIC SYNDROME;
   INSULIN-RECEPTOR; APOPTOSIS; PATHWAY; GENE; TRANSLATION
AB Purpose: Obesity is a global health problem associated with several diseases including ocular complications. Earlier we reported progressive retinal degeneration because of obesity in a spontaneous obese rat (WNIN/Ob) model. In the current study, we examined the molecular mechanisms leading to retinal degeneration in WNIN/Ob rat.
   Methods: Sorbitol was estimated by the fluorometric method in the retina of WNIN/Ob rats at different age (3-, 6- and 12- months), along with their respective lean rats. Immunoblotting was performed in the retina to assess the status of the insulin signaling pathway, ER stress and cellular stress (p38MAPK and ERK1/2). Human SK-N-SH cells were treated with 0.5 and 1.0 M sorbitol for 30 min to study insulin signaling, ER stress, and cellular stress. TUNEL assay was done to measure apoptosis. The retinal function in the rats was determined by electroretinogram.
   Results: A gradual but significantly higher intracellular sorbitol accumulation was observed in the retina of obese rats from 3- to 12-months. The cellular osmotic stress has activated the insulin signaling mechanism without activating AKT and also triggered ER stress. Both the stresses activated the ERK and p38MAPK signaling causing apoptosis in the retina leading to retinal degeneration. Retinal dysfunction was confirmed by altered scotopic and photopic electroretinogram responses. These in vivo results were mimicked in SK-N-SH cells when exposed to sorbitol in vitro.
   Conclusions: These results suggest cellular stress due to sorbitol accumulation impairing the ER function, thereby leading to progressive retinal degeneration under obese conditions.
C1 [Godisela, Kishore K.; Reddy, Singareddy Sreenivasa; Reddy, P. Yadagiri; Kumar, Ch Uday; Reddy, V. Sudhakar; Reddy, G. Bhanuprakash] Natl Inst Nutr, Biochem Div, Hyderabad, India.
   [Ayyagari, Radha] Univ Calif San Diego, Shiley Eye Inst, La Jolla, CA 92093 USA.
C3 Indian Council of Medical Research (ICMR); ICMR - National Institute of
   Nutrition (NIN); University of California System; University of
   California San Diego
RP Reddy, GB (corresponding author), Natl Inst Nutr, Hyderabad 500007, India.
EM geereddy@yahoo.com
RI CHEKKILLA, UDAY KUMAR/IQV-1932-2023; Reddy, G.
   Bhanuprakash/AAJ-3494-2020
OI Reddy, VS/0000-0002-2775-1766; Chekkilla, Uday
   Kumar/0000-0003-0255-5707; Reddy, G. Bhanuprakash/0000-0003-4787-3944;
   Reddy, Sreenivasa/0000-0003-3777-407X
FU SERB [SB/YS/LS271/2013]; Council of Scientific & Industrial Research
   (CSIR), India [B-12320]; Department of Biotechnology, Government of
   India under the Indo-US Vision Research Program
   [BT/PR11097/Med/12/411/2008]
FX KKG is a Fellow of the University Grants Commission-Faculty Development
   Program. SSR received a grant from SERB (SB/YS/LS271/2013), and Council
   of Scientific & Industrial Research (CSIR), India (Senior Research
   Associateship -No. B-12320). GBR received grants from the Department of
   Biotechnology, Government of India (BT/PR11097/Med/12/411/2008) under
   the Indo-US Vision Research Program.
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NR 55
TC 9
Z9 10
U1 0
U2 2
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0003-9861
EI 1096-0384
J9 ARCH BIOCHEM BIOPHYS
JI Arch. Biochem. Biophys.
PD JAN 15
PY 2020
VL 679
AR 108207
DI 10.1016/j.abb.2019.108207
PG 10
WC Biochemistry & Molecular Biology; Biophysics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics
GA LC6LB
UT WOS:000525443900010
PM 31760123
DA 2025-06-11
ER

PT J
AU Li, KY
   Li, KW
   Yao, QM
   Shui, XR
   Zheng, J
   He, Y
   Lei, W
AF Li, Kaiyue
   Li, Kongwei
   Yao, Qingmei
   Shui, Xiaorong
   Zheng, Jing
   He, Yuan
   Lei, Wei
TI The potential relationship of coronary artery disease and hyperuricemia:
   A cardiometabolic risk factor
SO HELIYON
LA English
DT Review
DE Hyperuricemia; Coronary arterial disease; Uric acid; Atherosclerosis;
   Pathophysiology
ID SERUM URIC-ACID; FOAM-CELL-FORMATION; OXIDATIVE STRESS;
   INSULIN-RESISTANCE; LONG-TERM; ASYMPTOMATIC HYPERURICEMIA;
   CARDIOVASCULAR-DISEASES; ANGIOTENSIN-II; NADPH OXIDASE; MORTALITY
AB Coronary arterial disease (CAD) is the leading cause of mortality in the world. Hyperuricemia has recently emerged as a novel independent risk factor of CAD, in addition to the traditional risk factors such as hyperlipidemia, smoking, and obesity. Several clinical studies have shown that hyperuricemia is strongly associated with the risk, progression and poor prognosis of CAD, as well as verifying an association with traditional CAD risk factors. Uric acid or enzymes in the uric acid production pathway are associated with inflammation, oxidative stress, regulation of multiple signaling pathways and the renin-angiotensin-aldosterone system (RAAS), and these pathophysiological alterations are currently the main mechanisms of coronary atherosclerosis formation. The risk of death from CAD can be effectively reduced by the uric acid-lowering therapy, but the interventional treatment of uric acid levels in patients with CAD remains controversial due to the diversity of co-morbidities and the complexity of causative factors. In this review, we analyze the association between hyperuricemia and CAD, elucidate the possible mechanisms by which uric acid induces or exacerbates CAD, and discuss the benefits and drawbacks of uric acid-lowering therapy. This review could provide theoretical references for the prevention and management of hyperuricemia-associated CAD.
C1 [Li, Kaiyue; Li, Kongwei; Yao, Qingmei; He, Yuan; Lei, Wei] Univ Joint Lab Guangdong Prov & Macao Reg Mol Targ, Affiliated Hosp Guangdong Med Univ, Guangdong Prov Engn Technol Res Ctr Mol Diag & Inn, Dept Precis Lab, Zhanjiang, Guangdong, Peoples R China.
   [He, Yuan] Guangdong Med Univ, Affiliated Hosp, Lab Cardiovasc Dis, Zhanjiang, Guangdong, Peoples R China.
   [Li, Kongwei] Guangdong Med Univ, Affiliated Hosp, Cardiovasc Med Ctr, Zhanjiang, Guangdong, Peoples R China.
   [Shui, Xiaorong] Guangdong Med Univ, Affiliated Hosp, Lab Vasc Surg, Zhanjiang, Guangdong, Peoples R China.
   [Zheng, Jing] Univ Wisconsin, Dept Obstet & Gynecol, Madison, WI USA.
   [He, Yuan; Lei, Wei] 57 Renmin Southern Rd, Zhanjiang 524001, Guangdong, Peoples R China.
C3 Guangdong Medical University; Guangdong Medical University; Guangdong
   Medical University; Guangdong Medical University; University of
   Wisconsin System; University of Wisconsin Madison
RP He, Y; Lei, W (corresponding author), 57 Renmin Southern Rd, Zhanjiang 524001, Guangdong, Peoples R China.
EM 31178078397@qq.com; leiwei@gdmu.edu.cn
RI He, Yuan/GVT-7268-2022
FU Discipline Construction Project of Guangdong Medical University
   [4SG21233G]; National Natural Science Foundation of China, China
   [81700269]; Key platform of Department of Education of Guangdong
   Province, China [2021LSYS007]; Science and Technology Program of
   Zhanjiang, China [2022E05011, 2022A01196, 2021A05158, 2021A05058,
   2021A05056, 2020A01020, 2020A06003, 2020A06004]
FX This work was supported by Discipline Construction Project of Guangdong
   Medical University (4SG21233G) , National Natural Science Foundation of
   China, China (81700269) , Key platform of Department of Education of
   Guangdong Province, China (2021LSYS007) , and Science and Technology
   Program of Zhanjiang, China (2022E05011, 2022A01196, 2021A05158,
   2021A05058, 2021A05056, 2020A01020, 2020A06003, 2020A06004) .
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NR 113
TC 19
Z9 19
U1 4
U2 19
PU CELL PRESS
PI CAMBRIDGE
PA 50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA
EI 2405-8440
J9 HELIYON
JI Heliyon
PD MAY
PY 2023
VL 9
IS 5
AR e16097
DI 10.1016/j.heliyon.2023.e16097
EA MAY 2023
PG 11
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA M3XP1
UT WOS:001029557600001
PM 37215840
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Carpenter, C
   Byun, SE
   Turner-McGrievy, G
   West, D
AF Carpenter, Chelsea
   Byun, Sang-Eun
   Turner-McGrievy, Gabrielle
   West, Delia
TI An Exploration of Domain-Specific Sedentary Behaviors in College
   Students by Lifestyle Factors and Sociodemographics
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Article
DE screen-time; sedentary behavior; adolescents; obesity
ID PHYSICAL-ACTIVITY QUESTIONNAIRE; SCREEN TIME; CARDIOMETABOLIC RISK;
   UNIVERSITY-STUDENTS; SLEEP QUALITY; ASSOCIATIONS; RELIABILITY; ADULTS;
   HEALTH; BIOMARKERS
AB College students exhibit high levels of sedentary time and/or poor lifestyle factors (e.g., poor sleep, stress, physical inactivity). It is unknown; however, in what domains college students spend their sedentary time and whether there are associations between sedentary time and these lifestyle factors. This study examined sedentary behavior of college students by domains, current lifestyle factors and sociodemographics. Undergraduates (n = 272, M age = 20 years, 79% female) self-reported their sedentary behavior, sleep, stress, physical activity, anthropometrics and sociodemographics. Sedentary time was categorized as: total, recreational screen, education and social. Students reported spending > 12 h of their day sedentary on average, with over a third of this time spent in recreational screen time. All categories of sedentary time were significantly correlated with body mass index, and both total sedentary time and screen time were significantly correlated with sleep score, with poorer sleep quality associated with greater sedentary time. Physical activity was negatively correlated with social sedentary time only. Subgroups with elevated sedentary time included minority students, those with low parental education and students with overweight/obesity. Given the negative health impacts of sedentary behavior, college students would likely benefit from interventions tailored to this population which target reducing sedentary time, particularly recreational screen time.
C1 [Carpenter, Chelsea] Univ Florida, Coll Publ Hlth & Hlth Profess, Dept Clin & Hlth Psychol, Gainesville, FL 32610 USA.
   [Byun, Sang-Eun] Univ South Carolina, Coll Hospitality Retail & Sport Management, Dept Retailing, Columbia, SC 29208 USA.
   [Turner-McGrievy, Gabrielle] Univ South Carolina, Arnold Sch Publ Hlth, Dept Hlth Promot Educ & Behav, Columbia, SC 29208 USA.
   [West, Delia] Univ South Carolina, Arnold Sch Publ Hlth, Dept Exercise Sci, Columbia, SC 29208 USA.
C3 State University System of Florida; University of Florida; University of
   South Carolina System; University of South Carolina Columbia; University
   of South Carolina System; University of South Carolina Columbia;
   University of South Carolina System; University of South Carolina
   Columbia
RP West, D (corresponding author), Univ South Carolina, Arnold Sch Publ Hlth, Dept Exercise Sci, Columbia, SC 29208 USA.
EM clarsen1@phhp.ufl.edu; sbyun@mailbox.sc.edu; brie@sc.edu;
   westds@mailbox.sc.edu
RI Turner-McGrievy, Brie/I-7319-2019; West, Delia/GWV-5839-2022
OI West, Delia/0000-0002-4375-2785; Carpenter, Chelsea/0000-0001-8834-7137
FU National Institutes of Health and National Institute of General Medical
   Sciences [T32-GM081740]; University of South Carolina Technology Center
   to Promote Healthy Lifestyles
FX This work was supported by the National Institutes of Health and
   National Institute of General Medical Sciences [T32-GM081740] and the
   University of South Carolina Technology Center to Promote Healthy
   Lifestyles (CC). This publication's contents are solely the
   responsibility of the authors and do not necessarily represent the
   official views of the NIGMS or NIH.
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NR 60
TC 15
Z9 19
U1 12
U2 60
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD SEP
PY 2021
VL 18
IS 18
AR 9930
DI 10.3390/ijerph18189930
PG 11
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA UV5FK
UT WOS:000699503900001
PM 34574852
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU DeVallance, E
   Li, Y
   Jurczak, MJ
   Cifuentes-Pagano, E
   Pagano, PJ
AF DeVallance, Evan
   Li, Yao
   Jurczak, Michael J.
   Cifuentes-Pagano, Eugenia
   Pagano, Patrick J.
TI The Role of NADPH Oxidases in the Etiology of Obesity and Metabolic
   Syndrome: Contribution of Individual Isoforms and Cell Biology
SO ANTIOXIDANTS & REDOX SIGNALING
LA English
DT Review
DE NADPH oxidases; metabolic disease; obesity; diabetes; ROS
ID NITRIC-OXIDE SYNTHASE; PERIVASCULAR ADIPOSE-TISSUE;
   NECROSIS-FACTOR-ALPHA; VASCULAR OXIDATIVE STRESS; SMOOTH-MUSCLE-CELLS;
   SKELETAL-MUSCLE; ENDOTHELIAL DYSFUNCTION; INSULIN-RESISTANCE;
   HYDROGEN-PEROXIDE; DIABETES-MELLITUS
AB Recent Advances: The primary goal of this review is to highlight recent advances and survey our present understanding of cell-specific NOX enzyme contributions to metabolic diseases. Critical Issues: However, due to the short half-lives of individual ROS and/or cellular defense systems, radii of ROS diffusion are commonly short, often restricting redox signaling and oxidant stress to localized events. Thus, special emphasis should be placed on cell type and subcellular location of NOX enzymes to better understand their role in the pathophysiology of metabolic diseases. Future Directions: We discuss the targeting of NOX enzymes as potential therapy and bring to light potential emerging areas of NOX research, microparticles and epigenetics, in the context of metabolic disease.
C1 [DeVallance, Evan; Li, Yao; Cifuentes-Pagano, Eugenia; Pagano, Patrick J.] Univ Pittsburgh, Dept Pharmacol & Chem Biol, Pittsburgh, PA USA.
   [DeVallance, Evan; Li, Yao; Cifuentes-Pagano, Eugenia; Pagano, Patrick J.] Univ Pittsburgh, Vasc Med Inst, Pittsburgh Heart Lung & Blood, Pittsburgh, PA USA.
   [Jurczak, Michael J.] Univ Pittsburgh, Dept Med, Div Endocrinol & Metab, Pittsburgh, PA USA.
   [Jurczak, Michael J.] Univ Pittsburgh, Ctr Metab & Mitochondrial Med, Pittsburgh, PA USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE); University
   of Pittsburgh; Pennsylvania Commonwealth System of Higher Education
   (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of
   Higher Education (PCSHE); University of Pittsburgh; Pennsylvania
   Commonwealth System of Higher Education (PCSHE); University of
   Pittsburgh
RP Pagano, PJ (corresponding author), Univ Pittsburgh, Vasc Med Inst, BST E1240,200 Lothrop St, Pittsburgh, PA 15261 USA.
EM pagano@pitt.edu
RI Pagano, Patrick/GYO-2619-2022; Stefanadis, Christodoulos/ABH-2232-2020
OI Li, Yao/0000-0002-7872-1495; Stefanadis,
   Christodoulos/0000-0001-5974-6454; Cifuentes-Pagano,
   Eugenia/0000-0002-2482-080X
FU NIH [R01HL112914, R01HL079207, P01HL103455, T32 GM008424, T32 HL007563,
   DK114012]
FX We thank Sanghamitra Sahoo, PhD, for her constructive criticism of this
   review. This work was supported by NIH grants R01HL112914, R01HL079207,
   P01HL103455, and T32 GM008424 (to P.J.P.); T32 HL007563 (E.D); and
   DK114012 (M.J.J).
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NR 233
TC 59
Z9 61
U1 0
U2 18
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1523-0864
EI 1557-7716
J9 ANTIOXID REDOX SIGN
JI Antioxid. Redox Signal.
PD OCT 1
PY 2019
VL 31
IS 10
BP 687
EP 709
DI 10.1089/ars.2018.7674
PG 23
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA IT5VY
UT WOS:000482937300002
PM 31250671
OA Green Published
DA 2025-06-11
ER

PT J
AU Mozos, I
   Stoian, D
   Caraba, A
   Malainer, C
   Horbanczuk, JO
   Atanasov, AG
AF Mozos, Ioana
   Stoian, Dana
   Caraba, Alexandru
   Malainer, Clemens
   Horbanczuk, Jaroslaw O.
   Atanasov, Atanas G.
TI Lycopene and Vascular Health
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Review
DE lycopene; arterial stiffness; endothelial function; intima-media
   thickness; cardiovascular risk
ID INTIMA-MEDIA THICKNESS; ENDOPLASMIC-RETICULUM STRESS; ACUTE
   MYOCARDIAL-INFARCTION; LOW SERUM LYCOPENE; ARTERIAL STIFFNESS; OXIDATIVE
   STRESS; DIETARY SUPPLEMENTATION; CARDIOVASCULAR-DISEASE; TOMATO
   LYCOPENE; WATERMELON SUPPLEMENTATION
AB Lycopene is a lipophilic, unsaturated carotenoid, found in red-colored fruits and vegetables, including tomatoes, watermelon, papaya, red grapefruits, and guava. The present work provides an up to date overview of mechanisms linking lycopene in the human diet and vascular changes, considering epidemiological data, clinical studies, and experimental data. Lycopene may improve vascular function and contributes to the primary and secondary prevention of cardiovascular disorders. The main activity profile of lycopene includes antiatherosclerotic, antioxidant, anti-inflammatory, antihypertensive, antiplatelet, anti-apoptotic, and protective endothelial effects, the ability to improve the metabolic profile, and reduce arterial stiffness. In this context, lycopene has been shown in numerous studies to exert a favorable effect in patients with subclinical atherosclerosis, metabolic syndrome, hypertension, peripheral vascular disease, stroke and several other cardiovascular disorders, although the obtained results are sometimes inconsistent, which warrants further studies focusing on its bioactivity.
C1 [Mozos, Ioana] Victor Babes Univ Med & Pharm, Dept Funct Sci, Timisoara, Romania.
   [Mozos, Ioana] Victor Babes Univ Med & Pharm, Ctr Translat Res & Syst Med, Timisoara, Romania.
   [Stoian, Dana] Victor Babes Univ Med & Pharm, Dept Internal Med 2, Timisoara, Romania.
   [Caraba, Alexandru] Victor Babes Univ Med & Pharm, Dept Internal Med 1, Timisoara, Romania.
   [Horbanczuk, Jaroslaw O.; Atanasov, Atanas G.] Polish Acad Sci, Inst Genet & Anim Breeding, Magdalenka, Poland.
   [Atanasov, Atanas G.] Univ Vienna, Dept Pharmacognosy, Fac Life Sci, Vienna, Austria.
C3 Victor Babes University of Medicine & Pharmacy, Timisoara; Victor Babes
   University of Medicine & Pharmacy, Timisoara; Victor Babes University of
   Medicine & Pharmacy, Timisoara; Victor Babes University of Medicine &
   Pharmacy, Timisoara; Institute of Genetics & Animal Biotechnology,
   Polish Academy of Sciences; Polish Academy of Sciences; University of
   Vienna
RP Mozos, I (corresponding author), Victor Babes Univ Med & Pharm, Dept Funct Sci, Timisoara, Romania.; Mozos, I (corresponding author), Victor Babes Univ Med & Pharm, Ctr Translat Res & Syst Med, Timisoara, Romania.; Atanasov, AG (corresponding author), Polish Acad Sci, Inst Genet & Anim Breeding, Magdalenka, Poland.; Atanasov, AG (corresponding author), Univ Vienna, Dept Pharmacognosy, Fac Life Sci, Vienna, Austria.
EM ioana_mozos@yahoo.com; a.atanasov.mailbox@gmail.com
RI Mozos, Ioana/AAB-4874-2020; Horbanczuk, Jaroslaw/ABD-8389-2021; Stoian,
   Dana/W-4777-2019; Caraba, Alexandru/AAH-8144-2021; Atanasov,
   Atanas/C-5535-2013; Stefanadis, Christodoulos/ABH-2232-2020
OI STOIAN, DANA/0000-0002-0926-9511; Caraba, Alexandru/0000-0003-1306-425X;
   Atanasov, Atanas/0000-0003-2545-0967; Mozos, Ioana/0000-0001-6353-7698;
   Stefanadis, Christodoulos/0000-0001-5974-6454
FU Polish KNOW (Leading National Research Centre) Scientific Consortium
   Healthy Animal-Safe Food, decision of Ministry of Science and Higher
   Education [05-1/KNOW2/2015]
FX The authors acknowledge the support by the Polish KNOW (Leading National
   Research Centre) Scientific Consortium Healthy Animal-Safe Food,
   decision of Ministry of Science and Higher Education No.
   05-1/KNOW2/2015.
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NR 137
TC 130
Z9 137
U1 10
U2 95
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD MAY 23
PY 2018
VL 9
AR 521
DI 10.3389/fphar.2018.00521
PG 16
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA GG6MJ
UT WOS:000432810700003
PM 29875663
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Haram, PM
   Kemi, OJ
   Wisloff, U
AF Haram, Per M.
   Kemi, Ole J.
   Wisloff, Ulrik
TI Adaptation of endothelium to exercise training: Insights from
   experimental studies
SO FRONTIERS IN BIOSCIENCE-LANDMARK
LA English
DT Review
DE artery; endothelium; exercise training; nitric oxide; shear stress;
   review
ID NITRIC-OXIDE SYNTHASE; CORONARY-ARTERY-DISEASE; PROGENITOR CELLS;
   SHEAR-STRESS; INSULIN-RESISTANCE; PHYSICAL-ACTIVITY; PLASMALEMMAL
   CAVEOLAE; INTRACELLULAR CALCIUM; DEPENDENT RELAXATION; MEDIATED DILATION
AB Endothelial dysfunction is one of the hallmarks of cardiovascular disease and serves as a prognostic marker for forecasting the development and outcome of the disease process. Current pharmacological treatment strategies only incompletely repair endothelial dysfunction whereas exercise training corrects this dysfunction, primarily due to improved production and/or bioavailability of nitric oxide, the main endothelium-derived vasodilator. This type of treatment also improves the function of healthy endothelium. The focus of this review is to discuss the underlying biological factors involved in improved endothelial function after exercise training in healthy individuals as well as those with cardiovascular disease or a metabolic syndrome. The ability to sustain the bioavailability of nitric oxide (NO) in the endothelium is probably the most important factor in restoring normal endothelial function by exercise training.
C1 [Haram, Per M.] Univ Hosp N Norway, Dept Cardiothorac & Vasc Surg, N-9038 Tromso, Norway.
   [Kemi, Ole J.] Univ Glasgow, Inst Biomed & Life Sci, Glasgow, Lanark, Scotland.
   [Wisloff, Ulrik] Norwegian Univ Sci & Technol, Dept Circulat & Med Imaging, N-7034 Trondheim, Norway.
   [Wisloff, Ulrik] St Olavs Hosp, Dept Cardiol, Trondheim, Norway.
C3 UiT The Arctic University of Tromso; University Hospital of North
   Norway; University of Glasgow; Norwegian University of Science &
   Technology (NTNU); Norwegian University of Science & Technology (NTNU)
RP Haram, PM (corresponding author), Univ Hosp N Norway, Dept Cardiothorac & Vasc Surg, Postbox 102, N-9038 Tromso, Norway.
EM Per.Magnus.Haram@unn.no
RI Wisloff, Ulrik/K-2899-2012
OI Wisloff, Ulrik/0000-0002-7211-3587; Kemi, Ole Johan/0000-0003-1344-9512
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NR 100
TC 44
Z9 52
U1 0
U2 20
PU FRONTIERS IN BIOSCIENCE INC
PI IRVINE
PA 16471 SCIENTIFIC WAY, IRVINE, CA 92618 USA
SN 1093-9946
EI 1093-4715
J9 FRONT BIOSCI-LANDMRK
JI Front. Biosci.
PD JAN 1
PY 2008
VL 13
BP 336
EP 346
DI 10.2741/2683
PG 11
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA 299SQ
UT WOS:000255775700027
PM 17981551
OA Bronze
DA 2025-06-11
ER

PT J
AU Sigrist-Flores, SC
   Castañeda-Partida, L
   Campos-Aguilar, M
   Santos-Cruz, LF
   Miranda-Gutierrez, A
   Gallardo-Ortíz, IA
   Villalobos-Molina, R
   Dueñas-García, IE
   Heres-Pulido, ME
   Piedra-Ibarra, E
   Rosales-García, VH
   Jimenez-Flores, R
   Ponciano-Gómez, A
AF Cristobal Sigrist-Flores, Santiago
   Castaneda-Partida, Laura
   Campos-Aguilar, Myriam
   Felipe Santos-Cruz, Luis
   Miranda-Gutierrez, Aranza
   Gallardo-Ortiz, I. A.
   Villalobos-Molina, R.
   Elena Duenas-Garcia, Irma
   Eugenia Heres-Pulido, Maria
   Piedra-Ibarra, Elias
   Hugo Rosales-Garcia, Victor
   Jimenez-Flores, Rafael
   Ponciano-Gomez, Alberto
TI Variation in resistance to oxidative stress in Oregon-(R)R-flare and
   Canton-S strains of Drosophila melanogaster
SO TOXICOLOGY RESEARCH
LA English
DT Article
DE Canton-S; Oregon (R)R-flare; antioxidant response; Drosophila
   melanogaster; oxidative stress
ID LIFE-SPAN; ROS; OVEREXPRESSION; EXTENSION; GENES
AB All aerobic organisms are susceptible to damage by reactive oxygen species (ROS). ROS-induced damage has been associated with aging and diseases such as metabolic syndrome and cancer. However, not all organisms develop these diseases, nor do they age at the same rate; this is partially due to resistance to oxidative stress, a quantitative trait attributable to the interaction of factors including genetics and environmental. Drosophila melanogaster represents an ideal system to study how genetic variation can affect resistance to oxidative stress. In this work, oxidative stress (total and mitochondrial ROS), antioxidant response, and Cap 'n' collar isoform C and Spineless gene expression, one pesticide resistant (Oregon R(R)-flare) and wild-type (Canton-S) strains of D. melanogaster, were analyzed to test resistance to basal oxidative stress. ROS, catalase, and superoxide dismutase were determined by flow cytometry, and Cap 'n' collar isoform C and Spineless expression by qRT-PCR. The intensity of oxidative stress due to the pro-oxidant zearalenone in both was evaluated by flow cytometry. Data confirm expected differences in oxidative stress between strains that differ in Cyp450s levels. The Oregon (R)R-flare showed greater ROS, total and mitochondrial, compared to Canton-S. Regarding oxidative stress genes expression Cap 'n' collar isoform C and Spineless (Ss), Oregon R(R)-flare strain showed higher expression. In terms of response to zearalenone mycotoxin, Canton-S showed higher ROS concentration. Our data show variation in the resistance to oxidative stress among these strains of D. melanogaster.
C1 [Cristobal Sigrist-Flores, Santiago; Campos-Aguilar, Myriam; Miranda-Gutierrez, Aranza; Jimenez-Flores, Rafael; Ponciano-Gomez, Alberto] Univ Nacl Autonoma Mexico, Fac Estudios Super Iztacala, Lab Inmunol UMF, Los Barrios 1, Tlalnepantla 54090, Estado De Mexic, Mexico.
   [Castaneda-Partida, Laura; Felipe Santos-Cruz, Luis; Elena Duenas-Garcia, Irma; Eugenia Heres-Pulido, Maria] Univ Nacl Autonoma Mexico, Fac Estudios Super Iztacala, Toxicol Genet Biol, Los Barrios 1, Tlalnepantla 54090, Estado De Mexic, Mexico.
   [Gallardo-Ortiz, I. A.; Villalobos-Molina, R.] Univ Nacl Autonoma Mexico, Fac Estudios Super Iztacala, Unidad Biomed, Los Barrios 1, Tlalnepantla 54090, Estado De Mexic, Mexico.
   [Piedra-Ibarra, Elias] Univ Nacl Autonoma Mexico, Fac Estudios Super Iztacala, Fisiol Vegetal UBIPRO, Los Barrios 1, Tlalnepantla 54090, Estado De Mexic, Mexico.
   [Hugo Rosales-Garcia, Victor] Inst Politecn Nacl, Ctr Invest & Estudios Avanzados, Labs Nacl Serv Expt, Mexico City 07340, DF, Mexico.
C3 Universidad Nacional Autonoma de Mexico; Universidad Nacional Autonoma
   de Mexico; Universidad Nacional Autonoma de Mexico; Universidad Nacional
   Autonoma de Mexico; CINVESTAV - Centro de Investigacion y de Estudios
   Avanzados del Instituto Politecnico Nacional; Instituto Politecnico
   Nacional - Mexico
RP Ponciano-Gómez, A (corresponding author), Univ Nacl Autonoma Mexico, Fac Estudios Super Iztacala, Lab Inmunol UMF, Los Barrios 1, Tlalnepantla 54090, Estado De Mexic, Mexico.
RI CASTAÑEDA-PARTIDA, LAURA/ABD-1608-2020; Jimenez-Flores,
   Rafael/B-6830-2017; Sigrist Flores, Santiago/HSG-9877-2023
OI Sigrist Flores, Santiago Cristobal/0000-0001-5925-1347; Ponciano-Gomez,
   Alberto/0000-0002-1801-6575
FU UNAM [DGAPA-PAPIIT-IN227619]
FX This project was supported by DGAPA-PAPIIT-IN227619, UNAM.
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NR 40
TC 4
Z9 4
U1 0
U2 13
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 2045-452X
EI 2045-4538
J9 TOXICOL RES-UK
JI Toxicol. Res.
PD AUG
PY 2021
VL 10
IS 4
BP 817
EP 823
DI 10.1093/toxres/tfab066
EA JUL 2021
PG 7
WC Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Toxicology
GA UP9QZ
UT WOS:000695708900016
PM 34484673
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Schwingshackl, L
   Morze, J
   Hoffmann, G
AF Schwingshackl, Lukas
   Morze, Jakub
   Hoffmann, Georg
TI Mediterranean diet and health status: Active ingredients and
   pharmacological mechanisms
SO BRITISH JOURNAL OF PHARMACOLOGY
LA English
DT Review
ID VIRGIN OLIVE OIL; ALL-CAUSE MORTALITY; COLON-CANCER CELLS; ENDOTHELIAL
   FUNCTION; METABOLIC SYNDROME; OXIDATIVE STRESS; FOOD GROUPS; CONCISE
   GUIDE; CARDIOVASCULAR-DISEASE; INSULIN SENSITIVITY
AB The Mediterranean diet (MedDiet) is one of the most widely described and evaluated dietary patterns in scientific literature. It is characterized by high intakes of vegetables, legumes, fruits, nuts, grains, fish, seafood, extra virgin olive oil, and a moderate intake of red wine. A large body of observational and experimental evidence suggests that higher adherence to the MedDiet is associated with lower risk of mortality, cardiovascular disease, metabolic disease, and cancer. Current mechanisms underlying the beneficial effects of the MedDiet include reduction of blood lipids, inflammatory and oxidative stress markers, improvement of insulin sensitivity, enhancement of endothelial function, and antithrombotic function. Most likely, these effects are attributable to bioactive ingredients such as polyphenols, monounsaturated and polyunsaturated fatty acids, or fibre. This review will focus on both established and less established mechanisms of action of biochemical compounds contained in a MedDiet.
C1 [Schwingshackl, Lukas] Univ Freiburg, Inst Evidence Med, Fac Med, Breisacher Str 153, D-79110 Freiburg, Germany.
   [Schwingshackl, Lukas] Univ Freiburg, Med Ctr, Breisacher Str 153, D-79110 Freiburg, Germany.
   [Morze, Jakub] Univ Warmia & Mazury, Fac Food Sci, Dept Human Nutr, Olsztyn, Poland.
   [Hoffmann, Georg] Univ Vienna, Dept Nutr Sci, Vienna, Austria.
C3 University of Freiburg; University of Freiburg; University of Warmia &
   Mazury; University of Vienna
RP Schwingshackl, L (corresponding author), Univ Freiburg, Inst Evidence Med, Fac Med, Breisacher Str 153, D-79110 Freiburg, Germany.; Schwingshackl, L (corresponding author), Univ Freiburg, Med Ctr, Breisacher Str 153, D-79110 Freiburg, Germany.
EM schwingshackl@ifem.uni-freiburg.de
RI Schwingshackl, Lukas/AAC-4119-2019; Morze, Jakub/AAG-9910-2019;
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OI Schwingshackl, Lukas/0000-0003-3407-7594; Morze,
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NR 153
TC 200
Z9 202
U1 3
U2 37
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0007-1188
EI 1476-5381
J9 BRIT J PHARMACOL
JI Br. J. Pharmacol.
PD MAR
PY 2020
VL 177
IS 6
SI SI
BP 1241
EP 1257
DI 10.1111/bph.14778
EA JUL 2019
PG 17
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Pharmacology & Pharmacy
GA KY5TC
UT WOS:000478460300001
PM 31243760
OA Bronze, Green Published
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Craige, SM
   Reif, MM
   Kant, S
AF Craige, Siobhan M.
   Reif, Michaella M.
   Kant, Shashi
TI Mixed - Lineage Protein kinases (MLKs) in inflammation, metabolism, and
   other disease states
SO BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
LA English
DT Review
DE Signal transduction; Kinase; Inflammation; Metabolism; Insulin
   resistance; Disease; Mixed-lineage kinase
ID N-TERMINAL KINASE; ISCHEMIC BRAIN-INJURY; INSULIN-RESISTANCE;
   LEUCINE-ZIPPER; MUSCLE-CELLS; NEURONAL DEGENERATION; SIGNALING PATHWAYS;
   MOLECULAR-CLONING; JNK PATHWAY; TNF-ALPHA
AB Mixed lineage kinases, or MLKs, are members of the MAP kinase kinase kinase (MAP3K) family, which were originally identified among the activators of the major stress-dependent mitogen activated protein kinases (MAPKs), JNK and p38. During stress, the activation of JNK and p38 kinases targets several essential downstream substrates that react in a specific manner to the unique stressor and thus determine the fate of the cell in response to a particular challenge. Recently, the MLK family was identified as a specific modulator of JNK and p38 signaling in metabolic syndrome. Moreover, the MLK family of kinases appears to be involved in a very wide spectrum of disorders. This review discusses the newly identified functions of MLKs in multiple diseases including metabolic disorders, inflammation, cancer, and neurological diseases. (C) 2016 Elsevier B.V. All rights reserved.
C1 [Craige, Siobhan M.; Reif, Michaella M.; Kant, Shashi] Univ Massachusetts, Sch Med, Dept Med, Div Cardiovasc Med, 368 Plantation St,AS7-1018, Worcester, MA 01605 USA.
C3 University of Massachusetts System; University of Massachusetts
   Worcester
RP Kant, S (corresponding author), Univ Massachusetts, Sch Med, Dept Med, Div Cardiovasc Med, 368 Plantation St,AS7-1018, Worcester, MA 01605 USA.
EM shashi.kant@umassmed.edu
RI Craige, Siobhan/MTE-9262-2025; Kant, Shashi/B-1585-2016
OI Kant, Shashi/0000-0001-8772-6813
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NR 81
TC 34
Z9 34
U1 0
U2 11
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0925-4439
EI 0006-3002
J9 BBA-MOL BASIS DIS
JI Biochim. Biophys. Acta-Mol. Basis Dis.
PD SEP
PY 2016
VL 1862
IS 9
BP 1581
EP 1586
DI 10.1016/j.bbadis.2016.05.022
PG 6
WC Biochemistry & Molecular Biology; Biophysics; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Cell Biology
GA DT5PU
UT WOS:000381535900012
PM 27259981
DA 2025-06-11
ER

PT J
AU Xu, JQ
   Shen, JY
   Yuan, RL
   Jia, BN
   Zhang, YW
   Wang, SJ
   Zhang, Y
   Liu, MY
   Wang, T
AF Xu, Jingqi
   Shen, Jiayan
   Yuan, Ruolan
   Jia, Bona
   Zhang, Yiwen
   Wang, Sijian
   Zhang, Yi
   Liu, Mengyang
   Wang, Tao
TI Mitochondrial Targeting Therapeutics: Promising Role of Natural Products
   in Non-alcoholic Fatty Liver Disease
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Review
DE non-alcoholic fatty liver disease; mitochondrial dysfunction; natural
   products; oxidative stress; metabolic syndrome
AB Non-alcoholic fatty liver disease (NAFLD) has become one of the most common chronic liver diseases worldwide, and its prevalence is still growing rapidly. However, the efficient therapies for this liver disease are still limited. Mitochondrial dysfunction has been proven to be closely associated with NAFLD. The mitochondrial injury caused reactive oxygen species (ROS) production, and oxidative stress can aggravate the hepatic lipid accumulation, inflammation, and fibrosis. which contribute to the pathogenesis and progression of NAFLD. Therefore, pharmacological therapies that target mitochondria could be a promising way for the NAFLD intervention. Recently, natural products targeting mitochondria have been extensively studied and have shown promising pharmacological activity. In this review, the recent research progress on therapeutic effects of natural-product-derived compounds that target mitochondria and combat NAFLD was summarized, aiming to provide new potential therapeutic lead compounds and reference for the innovative drug development and clinical treatment of NAFLD.
C1 [Xu, Jingqi; Zhang, Yiwen; Zhang, Yi; Liu, Mengyang; Wang, Tao] Tianjin Univ Tradit Chinese Med, State Key Lab Component Based Chinese Med, Tianjin, Peoples R China.
   [Shen, Jiayan; Yuan, Ruolan; Wang, Sijian; Liu, Mengyang; Wang, Tao] Tianjin Univ Tradit Chinese Med, Inst Tradit Chinese Med, Tianjin, Peoples R China.
   [Jia, Bona] Tianjin Med Univ, Sch Basic Med Sci, Dept Biochem & Mol Biol, Tianjin, Peoples R China.
C3 Tianjin University of Traditional Chinese Medicine; Tianjin University
   of Traditional Chinese Medicine; Tianjin Medical University
RP Liu, MY; Wang, T (corresponding author), Tianjin Univ Tradit Chinese Med, State Key Lab Component Based Chinese Med, Tianjin, Peoples R China.; Liu, MY; Wang, T (corresponding author), Tianjin Univ Tradit Chinese Med, Inst Tradit Chinese Med, Tianjin, Peoples R China.
EM liumengyang0212@tjutcm.edu.cn; wangtao@tjutcm.edu.cn
RI Zhang, Yiwen/GWM-7219-2022; Wang, SiJian/KTI-4031-2024; Wang,
   Tao/KYP-7917-2024; /AAA-6289-2019
OI /0000-0002-3790-923X
FU National Natural Science Foundation of China [82004062, 81802523];
   Research Program of Tianjin Municipal Education Commission [2017KJ129]
FX This work was supported by the National Natural Science Foundation of
   China (No. 82004062 and 81802523) and the Research Program of Tianjin
   Municipal Education Commission (No. 2017KJ129).
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NR 130
TC 30
Z9 32
U1 4
U2 15
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD DEC 23
PY 2021
VL 12
AR 796207
DI 10.3389/fphar.2021.796207
PG 15
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA VM5WK
UT WOS:001027372500001
PM 35002729
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Hege, A
   Lemke, MK
   Apostolopoulos, Y
   Perko, M
   Sönmez, S
   Strack, R
AF Hege, Adam
   Lemke, Michael Kenneth
   Apostolopoulos, Yorghos
   Perko, Mike
   Sonmez, Sevil
   Strack, Robert
TI US long-haul truck driver work organization and the association with
   cardiometabolic disease risk
SO ARCHIVES OF ENVIRONMENTAL & OCCUPATIONAL HEALTH
LA English
DT Article
DE Cardiometabolic disease (CMD); LHTD; obesity; work organization
ID COMMERCIAL DRIVERS; METABOLIC SYNDROME; NATIONAL-SURVEY; JOB STRAIN;
   OBESITY; HEALTH; SAFETY; PREVALENCE; WEIGHT; INJURY
AB Work organization, including long working hours, irregular work schedules, and job stress, has been associated with increased cardiometabolic disease (CMD) risk for numerous working populations. The purpose of this study was to examine the associations between work hours, work schedules, job stress, and CMD risk for a sample of US long-haul truck drivers (LHTDs). A nonexperimental, descriptive, cross-sectional design was employed to collect survey and anthropometric data from 260 US LHTDs at a major truck stop. The mean BMI was 33.40 kg/m(2) and mean waist circumference was 114.77cm. Using logistic regression, researchers found longer work hours, especially greater than 11hours daily, were associated with increased odds for an extremely high risk of CMD. Results support comprehensive and integrated approaches that address work organization, and in particular long working hours, to reduce drivers' CMD risk.
C1 [Hege, Adam] Appalachian State Univ, Dept Hlth & Exercise Sci, Holmes Convocat Ctr, 111 Rivers St, Boone, NC 28608 USA.
   [Lemke, Michael Kenneth; Apostolopoulos, Yorghos] Texas A&M Univ, Complex & Computat Populat Hlth Grp, College Stn, TX USA.
   [Lemke, Michael Kenneth; Apostolopoulos, Yorghos] Texas A&M Univ, Dept Hlth & Kinesiol, College Stn, TX USA.
   [Perko, Mike; Strack, Robert] Univ North Carolina Greensboro, Dept Publ Hlth Educ, Greensboro, NC USA.
   [Sonmez, Sevil] Univ Cent Florida, Dept Tourism & Attract, Orlando, FL 32816 USA.
C3 University of North Carolina; Appalachian State University; Texas A&M
   University System; Texas A&M University College Station; Texas A&M
   University System; Texas A&M University College Station; University of
   North Carolina; University of North Carolina Greensboro; State
   University System of Florida; University of Central Florida
RP Hege, A (corresponding author), Appalachian State Univ, Dept Hlth & Exercise Sci, Holmes Convocat Ctr, 111 Rivers St, Boone, NC 28608 USA.
EM hegeba@appstate.edu
RI Strack, Robert/E-1927-2016; Hege, Adam/AGF-0054-2022
OI Hege, Adam/0000-0003-2515-6848
FU University of North Carolina-Greensboro's (UNCG) Office of Research and
   Economic Development; UNCG's School of Health and Human Sciences; UNCG's
   Bryan School of Business and Economics; UNCG's Department of Public
   Health Education; UNCG's Department of Kinesiology
FX This article is part of a commercial driver sleep study conducted with
   research funds awarded to Yorghos Apostolopoulos by the University of
   North Carolina-Greensboro's (UNCG) Office of Research and Economic
   Development. Additional funds were provided by UNCG's School of Health
   and Human Sciences, Bryan School of Business and Economics, Department
   of Public Health Education, and Department of Kinesiology. The authors
   report no conflicts of interest.
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NR 41
TC 21
Z9 24
U1 1
U2 10
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 1933-8244
EI 2154-4700
J9 ARCH ENVIRON OCCUP H
JI Arch. Environ. Occup. Health
PY 2017
VL 72
IS 5
BP 303
EP 310
DI 10.1080/19338244.2016.1242468
PG 8
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA FC3ZI
UT WOS:000406777700009
PM 27684487
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Huang, YL
   Mai, WY
   Cai, XY
   Hu, YZ
   Song, YB
   Qiu, RF
   Wu, YX
   Kuang, J
AF Huang, Yuli
   Mai, Weiyi
   Cai, Xiaoyan
   Hu, Yunzhao
   Song, Yuanbin
   Qiu, Ruofeng
   Wu, Yanxian
   Kuang, Jian
TI The effect of zolpidem on sleep quality, stress status, and nondipping
   hypertension
SO SLEEP MEDICINE
LA English
DT Article
DE Nondipping hypertension; Pittsburgh Sleep Quality Index; Perceived
   Stress Scale; Zolpidem; Sympathetic nervous system; Ambulatory blood
   pressure monitoring
ID NOCTURNAL BLOOD-PRESSURE; METABOLIC SYNDROME SCORE; NON-DIPPERS;
   HONG-KONG; INSOMNIA; SAMPLE; WOMEN; FALL; CHRONOTHERAPY; ASSOCIATION
AB Objective: Poor sleep quality and stress status have previously been shown to be closely associated with higher activation of the sympathetic nervous system and to be independent predictors of nondipping hypertension. This study aimed to evaluate the effects of the non-hypotensive sedative zolpidem on sleep quality, stress status, and nondipping hypertension.
   Methods: A total of 103 nondippers were defined as poor or good sleepers by the Pittsburgh Sleep Quality Index. They were randomized to receive zolpidem or placebo treatment for 30 days. Stress status was assessed by the Perceived Stress Scale, and levels of epinephrine and norepinephrine were examined to investigate the underlying mechanisms.
   Results: Poor sleepers treated with zolpidem for 30 days showed significant improvements in sleep quality and stress levels (P < 0.01). More nondippers were converted to dippers in the group of poor sleepers treated with zolpidem (11 of 22 patients, 50.0%) than in the placebo (2 of 23, 8.7%) (P < 0.01). Epinephrine and norepinephrine levels were significantly reduced in poor sleepers treated with zolpidem (P < 0.05).
   Conclusion: The results of this study suggest that zolpidem can improve sleep quality and stress status, and can convert nondippers with poor sleep quality into dippers. It may be an option for treating nondipping hypertensive patients with poor sleep quality. (C) 2011 Elsevier B.V. All rights reserved.
C1 [Mai, Weiyi; Song, Yuanbin; Qiu, Ruofeng; Kuang, Jian] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Cardiol, Guangzhou 510080, Guangdong, Peoples R China.
   [Huang, Yuli; Hu, Yunzhao; Wu, Yanxian] First Peoples Hosp Shunde, Dept Cardiol, Foshan, Peoples R China.
   [Cai, Xiaoyan] First Peoples Hosp Shunde, Dept Burn, Foshan, Peoples R China.
C3 Sun Yat Sen University
RP Mai, WY (corresponding author), Sun Yat Sen Univ, Affiliated Hosp 1, Dept Cardiol, 58 Zhongshan Rd 2, Guangzhou 510080, Guangdong, Peoples R China.
EM wymai@hotmail.com
RI Huang, Yuli/AAB-1006-2022; Qiu, Ruofeng/R-5465-2016
FU Municipal Health Bureau of Foshan, Guangdong, China [2010385]; Natural
   Science Foundation of Guangdong Province, China [8151008901000157];
   Scientific Research Fund of Guangdong, China [2008B030301045,
   2009A030301004, 2011B031800021]
FX Financial Support: The project is supported by Medical Scientific
   Research Fund of Municipal Health Bureau of Foshan, Guangdong, China
   (No: 2010385), the Natural Science Foundation of Guangdong Province,
   China (No: 8151008901000157), and the Scientific Research Fund of
   Guangdong, China (No: 2008B030301045, 2009A030301004, 2011B031800021).
   We thank Professor Yuantao Hao, Professor Zefang Ren (from Sun Yat-sen
   University, China) and Doctor Dangdang Yu (from Southern Medical
   University, China) for their great help in Statistical analysis, and
   Professor Jiyang Pan (from Jinan University, China) and Doctor Qiaoping
   Chen (from The First People's Hospital of Shunde, China) for their great
   help in management of PSQI and PSS.
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NR 39
TC 32
Z9 33
U1 1
U2 11
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1389-9457
J9 SLEEP MED
JI Sleep Med.
PD MAR
PY 2012
VL 13
IS 3
BP 263
EP 268
DI 10.1016/j.sleep.2011.07.016
PG 6
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 911CT
UT WOS:000301695600007
PM 22153779
DA 2025-06-11
ER

PT J
AU Selmi, C
   Montano, N
   Furlan, R
   Keen, CL
   Gershwin, ME
AF Selmi, Carlo
   Montano, Nicola
   Furlan, Raffaello
   Keen, Carl L.
   Gershwin, M. Eric
TI Inflammation and oxidative stress in obstructive sleep apnea syndrome
SO EXPERIMENTAL BIOLOGY AND MEDICINE
LA English
DT Review
DE intermittent hypoxia; reactive oxygen species; animal model; dietary
   supplement
ID CHRONIC INTERMITTENT HYPOXIA; NECROSIS-FACTOR-ALPHA; FACTOR-KAPPA-B;
   CARDIOVASCULAR-DISEASE; SYSTEMIC INFLAMMATION; METABOLIC SYNDROME;
   COGNITIVE DECLINE; VASCULAR-DISEASE; RISK-FACTORS; STEEP APNEA
AB Similar to obesity, with which it is closely associated, obstructive sleep apnea syndrome (OSAS) is rapidly becoming a worldwide epidemic. Current knowledge of its pathogenesis has been significantly enriched by numerous experimental studies that have demonstrated an important role of oxidative stress and inflammation. Furthermore, new and exciting data strongly connect these two components in the perpetuation of the condition via the overexpression of nuclear factor kappa B. Experimental data support the hypothesis that nutrition might represent a promising future approach with antioxidants currently being good candidates for the modulation of cardiovascular sequelae, although weight reduction and controlled positive airway pressure remain the only established treatments for OSAS. We discuss herein the recent literature that illustrates these new paradigms and speculate on possible implications and future scenarios.
C1 Univ Calif Davis, Sch Med, Genome & Biomed Sci Facil, Div Rheumatol Allergy & Clin Immunol, Davis, CA 95616 USA.
   Univ Milan, Dept Clin Sci Luigi Sacco, Div Internal Med 2, I-20157 Milan, Italy.
   Univ Calif Davis, Dept Nutr, Davis, CA 95616 USA.
C3 University of California System; University of California Davis;
   University of Milan; Luigi Sacco Hospital; University of California
   System; University of California Davis
RP Gershwin, ME (corresponding author), Univ Calif Davis, Sch Med, Genome & Biomed Sci Facil, Div Rheumatol Allergy & Clin Immunol, 451 E Hlth Sci Dr,Suite 6510, Davis, CA 95616 USA.
EM megershwin@ucdavis.edu
RI Selmi, Carlo/ABG-4899-2021; Montano, Nicola/K-9013-2016; Furlan,
   Raffaello/ACH-0541-2022
OI Furlan, Raffaello/0000-0001-5209-6786; Montano,
   Nicola/0000-0001-9206-0075; Selmi, Carlo/0000-0002-0323-0376
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NR 50
TC 38
Z9 44
U1 0
U2 3
PU SOC EXPERIMENTAL BIOLOGY MEDICINE
PI MAYWOOD
PA 195 WEST SPRING VALLEY AVE, MAYWOOD, NJ 07607-1727 USA
SN 1535-3702
J9 EXP BIOL MED
JI Exp. Biol. Med.
PD DEC
PY 2007
VL 232
IS 11
BP 1409
EP 1413
DI 10.3181/0704-MR-103
PG 5
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 236LT
UT WOS:000251305200003
PM 18040064
DA 2025-06-11
ER

PT J
AU Kesebir, S
AF Kesebir, Sermin
TI Metabolic syndrome and childhood trauma: Also comorbidity and
   complication in mood disorder
SO WORLD JOURNAL OF CLINICAL CASES
LA English
DT Review
DE Obesity; Dyslipidemia; Hypertension; Diabetes; Childhood trauma; Mood
   disorder
AB Studies for prevalence and causal relationship established that addressing comorbidities of mental illnesses with medical disease will be another revolution in psychiatry. Increasing number of evidence shows that there is a bidirectional connection between mood disorders and some medical diseases. Glucocorticoid/insulin signal mechanisms and immunoenflammatory effector systems are junction points that show pathophysiology between bipolar disorder and general medical situations susceptible to stress. A subgroup of mood disorder patients are under risk of developing obesity and diabetes. Their habits and life styles, genetic predisposition and treatment options are parameters that define this subgroup. Medical disease in adults had a significant relationship to adverse life experiences in childhood. This illustrates that adverse experiences in childhood are related to adult disease by two basic etiologic mechanisms: (1) conventional risk factors that actually are compensatory behaviors, attempts at self-help through the use of agents and foods; and (2) the effects of chronic stress. (c) 2014 Baishideng Publishing Group Inc. All rights reserved.
C1 [Kesebir, Sermin] Erenkoy Mental & Neurol Dis Training & Res Hosp, TR-34216 Istanbul, Turkey.
C3 Erenkoy Mental & Neurological Disorders Education & Research Hospital
RP Kesebir, S (corresponding author), Erenkoy Mental & Neurol Dis Training & Res Hosp, Psychiat, Sinan Ercan C 29, TR-34216 Istanbul, Turkey.
EM serminkesebir@hotmail.com
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NR 48
TC 10
Z9 11
U1 0
U2 9
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 7041 Koll Center Parkway, Suite 160, PLEASANTON, CA, UNITED STATES
SN 2307-8960
J9 WORLD J CLIN CASES
JI World J. Clin. Cases
PD AUG 16
PY 2014
VL 2
IS 8
BP 332
EP 337
DI 10.12998/wjcc.v2.i8.332
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA VJ1BI
UT WOS:000535484900003
PM 25133143
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Bowman, TA
   Ramakrishnan, SK
   Kaw, M
   Lee, SJ
   Patel, PR
   Golla, VK
   Bourey, RE
   Haram, PM
   Koch, LG
   Britton, SL
   Wisloff, U
   Lee, AD
   Najjar, SM
AF Bowman, Thomas A.
   Ramakrishnan, Sadeesh K.
   Kaw, Meenakshi
   Lee, Sang Jun
   Patel, Payal R.
   Golla, Varun K.
   Bourey, Raymond E.
   Haram, Per Magnus
   Koch, Lauren G.
   Britton, Steven L.
   Wisloff, Ulrik
   Lee, Abraham D.
   Najjar, Sonia M.
TI Caloric Restriction Reverses Hepatic Insulin Resistance and Steatosis in
   Rats with Low Aerobic Capacity
SO ENDOCRINOLOGY
LA English
DT Article
ID CARDIOVASCULAR RISK-FACTORS; CELL-ADHESION MOLECULE-1; FATTY-ACID
   SYNTHASE; NONALCOHOLIC STEATOHEPATITIS; LIVER; EXERCISE;
   HYPERINSULINEMIA; EXPRESSION; PP120/HA4; MECHANISM
AB Rats selectively bred for low aerobic running capacity exhibit the metabolic syndrome, including hyperinsulinemia, insulin resistance, visceral obesity, and dyslipidemia. They also exhibit features of nonalcoholic steatohepatitis, including chicken-wire fibrosis, inflammation, and oxidative stress. Hyperinsulinemia in these rats is associated with impaired hepatic insulin clearance. The current studies aimed to determine whether these metabolic abnormalities could be reversed by caloric restriction (CR). CR by 30% over a period of 2-3 months improved insulin clearance in parallel to inducing the protein content and activation of the carcinoembryonic antigen-related cell adhesion molecule 1, a main player in hepatic insulin extraction. It also reduced glucose and insulin intolerance and serum and tissue (liver and muscle) triglyceride levels. Additionally, CR reversed inflammation, oxidative stress, and fibrosis in liver. The data support a significant role of CR in the normalization of insulin and lipid metabolism in liver. (Endocrinology 151: 5157-5164, 2010)
C1 [Bowman, Thomas A.; Ramakrishnan, Sadeesh K.; Kaw, Meenakshi; Lee, Sang Jun; Patel, Payal R.; Golla, Varun K.; Bourey, Raymond E.; Lee, Abraham D.; Najjar, Sonia M.] Univ Toledo, Coll Med, Ctr Diabet & Endocrine Res, Toledo, OH 43614 USA.
   [Bowman, Thomas A.; Ramakrishnan, Sadeesh K.; Kaw, Meenakshi; Lee, Sang Jun; Patel, Payal R.; Golla, Varun K.; Najjar, Sonia M.] Univ Toledo, Coll Med, Dept Physiol & Pharmacol, Toledo, OH 43614 USA.
   [Bourey, Raymond E.] Univ Toledo, Coll Med, Dept Internal Med, Toledo, OH 43614 USA.
   [Lee, Abraham D.] Univ Toledo, Coll Med, Dept Phys Therapy, Toledo, OH 43614 USA.
   [Haram, Per Magnus] Univ Hosp, Dept Cardiothorac & Vasc Surg, N Norway, Norway.
   Univ Tromso, Inst Clin Med, Fac Med, N-9037 Tromso, Norway.
   [Haram, Per Magnus; Wisloff, Ulrik] Norwegian Univ Sci & Technol, Dept Circulat & Med Imaging, N-7034 Trondheim, Norway.
   [Koch, Lauren G.; Britton, Steven L.] Univ Michigan, Dept Anesthesiol, Ann Arbor, MI 48109 USA.
C3 University System of Ohio; University of Toledo; University System of
   Ohio; University of Toledo; University System of Ohio; University of
   Toledo; University System of Ohio; University of Toledo; UiT The Arctic
   University of Tromso; Norwegian University of Science & Technology
   (NTNU); University of Michigan System; University of Michigan
RP Najjar, SM (corresponding author), Univ Toledo, Coll Med, Ctr Diabet & Endocrine Res, Hlth Sci Campus,3000 Arlington Ave,Mail Stop 1008, Toledo, OH 43614 USA.
EM sonia.najjar@utoledo.edu
RI Wisloff, Ulrik/K-2899-2012; Koch, Lauren/D-1258-2010; Ramakrishnan,
   Sadeesh/JSK-9511-2023; Lee, Sang-Jun/A-3892-2015; Bowman,
   Thomas/I-4649-2013; najjar, sonia/GXW-2217-2022
OI Bowman, Thomas/0000-0002-9591-7561; najjar, sonia/0000-0001-6209-8902;
   Wisloff, Ulrik/0000-0002-7211-3587
FU National Institutes of Health [DK054254, DK083850]; United States
   Department of Agriculture [38903-02315]; National Center for Research
   Resource (National Institutes of Health) [R24RR017718]; Institutional
   funds; Norwegian Council of Cardiovascular Disease; Norwegian Research
   Council
FX This work was supported by the National Institutes of Health Grants
   DK054254 and DK083850 and by the United States Department of Agriculture
   Grant 38903-02315 (to S.M.N.). The work was also supported by the
   National Center for Research Resource (a component of the National
   Institutes of Health) Award R24RR017718 (to S. L. B. and L. G. K.), by
   institutional funds (R. E. B.), and by the Norwegian Council of
   Cardiovascular Disease and the Norwegian Research Council (U. W.).
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NR 28
TC 34
Z9 38
U1 0
U2 9
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0013-7227
EI 1945-7170
J9 ENDOCRINOLOGY
JI Endocrinology
PD NOV
PY 2010
VL 151
IS 11
BP 5157
EP 5164
DI 10.1210/en.2010-0176
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 667XY
UT WOS:000283231700010
PM 20861239
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Chen, Y
   Feng, RN
   Yang, X
   Dai, JX
   Huang, M
   Ji, XN
   Li, Y
   Okekunle, AP
   Gao, GH
   Onwuka, JU
   Pang, XY
   Wang, C
   Li, CL
   Li, Y
   Sun, CH
AF Chen, Yang
   Feng, Rennan
   Yang, Xue
   Dai, Jiaxing
   Huang, Min
   Ji, Xiaoning
   Li, Yong
   Okekunle, Akinkunmi Paul
   Gao, Guanghui
   Onwuka, Justina Ucheojor
   Pang, Xiuyu
   Wang, Cheng
   Li, Chunlong
   Li, Ying
   Sun, Changhao
TI Yogurt improves insulin resistance and liver fat in obese women with
   nonalcoholic fatty liver disease and metabolic syndrome: a randomized
   controlled trial
SO AMERICAN JOURNAL OF CLINICAL NUTRITION
LA English
DT Article
DE yogurt; insulin resistance; oxidative stress; inflammation; microbiota;
   NAFLD
ID CONJUGATED LINOLEIC-ACID; DAIRY-PRODUCTS; GUT MICROBIOTA; CONSUMPTION;
   RISK; ASSOCIATIONS; INFLAMMATION; HEALTH; GENOME; IMPACT
AB Background: Because consumption of conventional yogurt has beneficial effects in a healthy population, and insulin resistance (IR) is the mutual pathogenesis in nonalcoholic fatty liver disease (NAFLD) and metabolic syndrome (MetS), we hypothesized that yogurt would ameliorate IR in patients with NAFLD and MetS.
   Objectives: The aim of this study was to investigate the effects of yogurt on IR and secondary endpoints including liver fat, gut microbiota, and serum biomarkers of inflammation and oxidative stress in obese women with NAFLD and MetS.
   Methods: One hundred obese women aged 36-66 y with both NAFLD and MetS were randomly assigned to consume 220 g/d of either conventional yogurt or milk for 24 wk. At baseline and week 24, we measured anthropometric indices, serum glucose, insulin, lipids, and cytokines in all participants, and liver fat and gut microbiota in 20 participants randomly selected from each group.
   Results: Forty-eight participants from the yogurt group and 44 from the milk group completed the intervention. Compared with milk, yogurt significantly decreased the homeostasis model assessment of insulin resistance (-0.53; 95% CI: -1.03, -0.02), fasting insulin (-2.77 mU/L; 95% CI: -4.91, -0.63 mU/L), 2-h insulin (-25.5 mU/L; 95% CI: -33.0, -17.9 mU/L), 2-h area under the curve for insulin (-29.4 mU/L . h; 95% CI: -44.0, -14.8 mU/L . h), alanine aminotransferase (-4.65 U/L; 95% CI: -8.67, -0.64 U/L), intrahepatic lipid (-3.44%; 95% CI: -6.19%, -0.68%), and hepatic fat fraction (-3.48%; 95% CI: -6.34%, -0.63%). Yogurt also decreased serum LPS (-0.31 EU/mL; 95% CI: -0.48, -0.14 EU/mL), fibroblast growth factor 21 (-57.76 pg/mL; 95% CI: -86.32, -29.19 pg/mL), lipids, and biomarkers of inflammation and oxidative stress, and altered gut microbiota composition. Mediation analysis showed that yogurt may improve IR by reducing serum lipids, inflammation, oxidative stress, and LPS.
   Conclusions: Yogurt was better than milk at ameliorating IR and liver fat in obese Chinese women with NAFLD and MetS, possibly by improving lipid metabolism, reducing inflammation, oxidative stress, and LPS, and changing the gut microbiota composition. This trial was registered at www.chictr.org.cn as ChiCTR-IPR-15006801.
C1 [Chen, Yang; Feng, Rennan; Yang, Xue; Huang, Min; Ji, Xiaoning; Okekunle, Akinkunmi Paul; Pang, Xiuyu; Li, Ying; Sun, Changhao] Harbin Med Univ, Coll Publ Hlth, Dept Nutr & Food Hyg, Harbin, Heilongjiang, Peoples R China.
   [Onwuka, Justina Ucheojor] Harbin Med Univ, Coll Publ Hlth, Dept Epidemiol, Harbin, Heilongjiang, Peoples R China.
   [Wang, Cheng] Harbin Med Univ, Coll Publ Hlth, Dept Environm Hyg, Harbin, Heilongjiang, Peoples R China.
   [Feng, Rennan; Li, Yong] Harbin Med Univ, Training Ctr Students Innovat & Entrepreneurship, Harbin, Heilongjiang, Peoples R China.
   [Dai, Jiaxing] Harbin Med Univ, Affiliated Hosp 1, Dept Neurosurg, Harbin, Heilongjiang, Peoples R China.
   [Gao, Guanghui] Food Inspect Inst, Dept Phys & Chem, Shenyang, Liaoning, Peoples R China.
   [Li, Chunlong] Harbin Med Univ, Affiliated Hosp 2, Dept Gen Surg, Harbin, Heilongjiang, Peoples R China.
C3 Harbin Medical University; Harbin Medical University; Harbin Medical
   University; Harbin Medical University; Harbin Medical University; Harbin
   Medical University
RP Feng, RN; Sun, CH (corresponding author), Harbin Med Univ, Coll Publ Hlth, Dept Nutr & Food Hyg, Harbin, Heilongjiang, Peoples R China.; Feng, RN (corresponding author), Harbin Med Univ, Training Ctr Students Innovat & Entrepreneurship, Harbin, Heilongjiang, Peoples R China.
EM fengrennan@163.com; changhao2002sun@gmail.com
RI Chunlong, Li/AAM-8644-2021; Okekunle, Akinkunmi/AAC-9804-2020; Onwuka,
   Justina Ucheojor/O-6217-2019
OI /0000-0001-9416-7044; Onwuka, Justina Ucheojor/0000-0002-4236-1758;
   Okekunle, Akinkunmi/0000-0003-4825-4934; Dai,
   Jiaxing/0000-0001-5916-9124
FU National Natural Science Foundation of China [81872616, 81573133];
   Natural Science Foundation of Heilongjiang Province [H2016018];
   Heilongjiang Provincial Postdoctoral Commission Science Foundation
   [LBH-Q17089]
FX The study is supported by the National Natural Science Foundation of
   China (grants 81872616 and 81573133), Natural Science Foundation of
   Heilongjiang Province (grant H2016018), and Heilongjiang Provincial
   Postdoctoral Commission Science Foundation (grant LBH-Q17089) to RF. YC
   and RF contributed equally to this work.
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NR 50
TC 88
Z9 93
U1 5
U2 52
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0002-9165
EI 1938-3207
J9 AM J CLIN NUTR
JI Am. J. Clin. Nutr.
PD JUN
PY 2019
VL 109
IS 6
BP 1611
EP 1619
DI 10.1093/ajcn/nqy358
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA IM5XI
UT WOS:000478066900014
PM 31136662
OA Bronze
DA 2025-06-11
ER

PT J
AU Huang, P
   Zhu, YL
   Qin, J
AF Huang, Peng
   Zhu, Yunling
   Qin, Jian
TI Research advances in understanding crosstalk between organs and
   pancreatic β-cell dysfunction
SO DIABETES OBESITY & METABOLISM
LA English
DT Review
DE crosstalk; organ; pancreatic beta cells; T2DM; tissue
ID ISLET AMYLOID POLYPEPTIDE; STIMULATED INSULIN-SECRETION; GLUCAGON-LIKE
   PEPTIDE-1; ENDOPLASMIC-RETICULUM STRESS; RECEPTOR KNOCKOUT MICE; FATTY
   LIVER-DISEASE; GENE-EXPRESSION; ADIPOSE-TISSUE; SIGNALING PATHWAYS;
   OXIDATIVE STRESS
AB Obesity has increased dramatically worldwide. Being overweight or obese can lead to various conditions, including dyslipidaemia, hypertension, glucose intolerance and metabolic syndrome (MetS), which may further lead to type 2 diabetes mellitus (T2DM). Previous studies have identified a link between beta-cell dysfunction and the severity of MetS, with multiple organs and tissues affected. Identifying the associations between pancreatic beta-cell dysfunction and organs is critical. Research has focused on the interaction between the liver, gut and pancreatic beta-cells. However, the mechanisms and related core targets are still not perfectly elucidated. The aims of this review were to summarize the mechanisms of beta-cell dysfunction and to explore the potential pathogenic pathways and targets that connect the liver, gut, adipose tissue, muscle, and brain to pancreatic beta-cell dysfunction.
C1 [Huang, Peng; Zhu, Yunling; Qin, Jian] Sun Yat sen Univ, Affiliated Hosp 7, Dept Tradit Chinese Med, Shenzhen 518107, Guangdong, Peoples R China.
C3 Sun Yat Sen University
RP Qin, J (corresponding author), Sun Yat sen Univ, Affiliated Hosp 7, Dept Tradit Chinese Med, Shenzhen 518107, Guangdong, Peoples R China.
EM qinjian@sysush.com
RI Huang, Peng/HDN-1614-2022
OI Huang, Peng/0000-0001-9872-2834
FU Seventh Affiliated Hospital, Sun Yat-sen University [ZSQY7352021007]
FX The"735"Project of the Seventh Affiliated Hospital, Sun Yat-sen
   University, Grant/Award Number: ZSQY7352021007The '735'Project of the
   Seventh Affiliated Hospital, Sun Yat-sen Uni-versity (grant no.
   ZSQY7352021007).
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NR 259
TC 0
Z9 0
U1 1
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1462-8902
EI 1463-1326
J9 DIABETES OBES METAB
JI Diabetes Obes. Metab.
PD OCT
PY 2024
VL 26
IS 10
BP 4147
EP 4164
DI 10.1111/dom.15787
EA JUL 2024
PG 18
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA G9D9B
UT WOS:001274477800001
PM 39044309
DA 2025-06-11
ER

PT J
AU Ramasubbu, K
   Rajeswari, VD
AF Ramasubbu, Kanagavalli
   Rajeswari, V. Devi
TI Impairment of insulin signaling pathway PI3K/Akt/mTOR and insulin
   resistance induced AGEs on diabetes mellitus and neurodegenerative
   diseases: a perspective review
SO MOLECULAR AND CELLULAR BIOCHEMISTRY
LA English
DT Review
DE Insulin resistance; PI3; Akt; mTOR pathway; Advanced glycation end
   products; Neurodegenerative diseases
ID GLYCATION END-PRODUCTS; AMYOTROPHIC-LATERAL-SCLEROSIS;
   PARKINSONS-DISEASE; ALZHEIMERS-DISEASE; OXIDATIVE STRESS;
   ALPHA-SYNUCLEIN; IRS PROTEINS; AKT; MECHANISMS; RECEPTOR
AB Insulin resistance is common in type 2 diabetes mellitus (T2DM), neurodegenerative diseases, cardiovascular diseases, kidney diseases, and polycystic ovary syndrome. Impairment in insulin signaling pathways, such as the PI3K/Akt/mTOR pathway, would lead to insulin resistance. It might induce the synthesis and deposition of advanced glycation end products (AGEs), reactive oxygen species, and reactive nitrogen species, resulting in stress, protein misfolding, protein accumulation, mitochondrial dysfunction, reticulum function, and metabolic syndrome dysregulation, inflammation, and apoptosis. It plays a huge role in various neurodegenerative diseases like Parkinson's disease, Alzheimer's disease, Huntington's disease, and Amyloid lateral sclerosis. In this review, we intend to focus on the possible effect of insulin resistance in the progression of neurodegeneration via the impaired P13K/Akt/mTOR signaling pathway, AGEs, and receptors for AGEs.
C1 [Ramasubbu, Kanagavalli; Rajeswari, V. Devi] Vellore Inst Technol, Sch Biosci & Technol, Dept Biomed Sci, Vellore 632014, Tamil Nadu, India.
C3 Vellore Institute of Technology (VIT); VIT Vellore
RP Rajeswari, VD (corresponding author), Vellore Inst Technol, Sch Biosci & Technol, Dept Biomed Sci, Vellore 632014, Tamil Nadu, India.
EM vdevirajeswari@vit.ac.in
RI RAJESWARI, DEVI/T-3738-2019
OI RAJESWARI, DEVI/0000-0002-1914-6451
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NR 161
TC 91
Z9 95
U1 7
U2 42
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0300-8177
EI 1573-4919
J9 MOL CELL BIOCHEM
JI Mol. Cell. Biochem.
PD JUN
PY 2023
VL 478
IS 6
BP 1307
EP 1324
DI 10.1007/s11010-022-04587-x
EA OCT 2022
PG 18
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA F6QX0
UT WOS:000875804900002
PM 36308670
DA 2025-06-11
ER

PT J
AU Dunshee, DR
   Bainbridge, TW
   Kljavin, NM
   Zavala-Solorio, J
   Schroeder, AC
   Chan, R
   Corpuz, R
   Wong, M
   Zhou, W
   Deshmukh, G
   Ly, J
   Sutherlin, DP
   Ernst, JA
   Sonoda, J
AF Dunshee, Diana Ronai
   Bainbridge, Travis W.
   Kljavin, Noelyn M.
   Zavala-Solorio, Jose
   Schroeder, Amy C.
   Chan, Ruby
   Corpuz, Racquel
   Wong, Manda
   Zhou, Wei
   Deshmukh, Gauri
   Ly, Justin
   Sutherlin, Daniel P.
   Ernst, James A.
   Sonoda, Junichiro
TI Fibroblast Activation Protein Cleaves and Inactivates Fibroblast Growth
   Factor 21
SO JOURNAL OF BIOLOGICAL CHEMISTRY
LA English
DT Article
DE FGF; metabolic disease; protease inhibitor; proteolytic enzyme; serine
   protease; FGF21; dipeptidyl peptidase IV (DPPIV); fibroblast activation
   protein (FAP)
ID DIPEPTIDYL PEPTIDASE-4 INHIBITORS; ENDOPLASMIC-RETICULUM STRESS; SERUM
   FGF21 LEVELS; INSULIN SENSITIVITY; ENERGY-EXPENDITURE; METABOLIC
   SYNDROME; HEPATIC STEATOSIS; MICE; OBESITY; EXPRESSION
AB FGF21 is a stress-induced hormone with potent anti-obesity, insulin-sensitizing, and hepatoprotective properties. Although proteolytic cleavage of recombinant human FGF21 in preclinical species has been observed previously, the regulation of endogenously produced FGF21 is not well understood. Here we identify fibroblast activation protein (FAP) as the enzyme that cleaves and inactivates human FGF21. A selective chemical inhibitor, immunodepletion, or genetic deletion of Fap stabilized recombinant human FGF21 in serum. In addition, administration of a selective FAP inhibitor acutely increased circulating intact FGF21 levels in cynomolgus monkeys. On the basis of our findings, we propose selective FAP inhibition as a potential therapeutic approach to increase endogenous FGF21 activity for the treatment of obesity, type 2 diabetes, non-alcoholic steatohepatitis, and related metabolic disorders.
C1 [Dunshee, Diana Ronai; Zavala-Solorio, Jose; Schroeder, Amy C.; Sonoda, Junichiro] Genentech Inc, Mol Biol, San Francisco, CA 94080 USA.
   [Bainbridge, Travis W.; Chan, Ruby; Corpuz, Racquel; Wong, Manda; Ernst, James A.] Genentech Inc, Prot Chem, San Francisco, CA 94080 USA.
   [Kljavin, Noelyn M.] Genentech Inc, Mol Oncol, San Francisco, CA 94080 USA.
   [Zhou, Wei] Genentech Inc, Translat Oncol, San Francisco, CA 94080 USA.
   [Deshmukh, Gauri; Ly, Justin] Genentech Inc, Drug Metab & Pharmacokinet, San Francisco, CA 94080 USA.
   [Sutherlin, Daniel P.] Genentech Inc, Discovery Chem, San Francisco, CA 94080 USA.
C3 Roche Holding; Genentech; Roche Holding USA; Roche Holding; Roche
   Holding USA; Genentech; Roche Holding; Genentech; Roche Holding USA;
   Roche Holding; Genentech; Roche Holding USA; Roche Holding; Roche
   Holding USA; Genentech; Roche Holding; Roche Holding USA; Genentech
RP Sonoda, J (corresponding author), Genentech Inc, Mol Biol, San Francisco, CA 94080 USA.
EM junichis@gene.com
RI Deshmukh, Gauri/J-2448-2017
OI Wong, Manda/0000-0001-5830-1517; Dunshee, Diana/0000-0001-8930-1587
FU Genentech, Inc.
FX This work was funded by Genentech, Inc. All authors are present or
   former paid employees of Genentech with no further conflict of interest.
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U2 21
PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3996 USA
EI 1083-351X
J9 J BIOL CHEM
JI J. Biol. Chem.
PD MAR 11
PY 2016
VL 291
IS 11
BP 5986
EP 5996
DI 10.1074/jbc.M115.710582
PG 11
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA DH1NN
UT WOS:000372551800043
PM 26797127
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Rogers, EM
   Banks, NF
   Jenkins, NDM
AF Rogers, Emily M.
   Banks, Nile F.
   Jenkins, Nathaniel D. M.
TI The effects of sleep disruption on metabolism, hunger, and satiety, and
   the influence of psychosocial stress and exercise: A narrative review
SO DIABETES-METABOLISM RESEARCH AND REVIEWS
LA English
DT Review
DE adverse childhood experiences; cardiometabolic health; leptin; sleep
   duration; sleep quality
ID BODY-MASS INDEX; ADVERSE CHILDHOOD EXPERIENCES; FREE FATTY-ACIDS;
   SLOW-WAVE SLEEP; INSULIN-RESISTANCE; CARDIOMETABOLIC HEALTH;
   POSTMENOPAUSAL WOMEN; LEPTIN LEVELS; RISK-FACTORS; WEIGHT-GAIN
AB Sleep deficiency is a ubiquitous phenomenon among Americans. In fact, in the United States, similar to 78% of teens and 35% of adults currently get less sleep than recommended for their age-group, and the quality of sleep appears to be getting worse for many. The consequences of sleep disruption manifest in a myriad of ways, including insulin resistance and disrupted nutrient metabolism, dysregulation of hunger and satiety, and potentially increased body weight and adiposity. Consequently, inadequate sleep is related to an increased risk of various cardiometabolic diseases, including obesity, diabetes, and heart disease. Exercise has the potential to be an effective therapeutic to counteract the deleterious effects of sleep disruption listed above, whereas chronic psychosocial stress may causally promote sleep disruption and cardiometabolic risk. Here, we provide a narrative review of the current evidence on the consequences of short sleep duration and poor sleep quality on substrate metabolism, circulating appetite hormones, hunger and satiety, and weight gain. Secondly, we provide a brief overview of chronic psychosocial stress and its impact on sleep and metabolic health. Finally, we summarise the current evidence regarding the ability of exercise to counteract the adverse metabolic health effects of sleep disruption. Throughout the review, we highlight areas where additional interrogation and future exploration are necessary.
C1 [Rogers, Emily M.; Banks, Nile F.; Jenkins, Nathaniel D. M.] Univ Iowa, Integrat Lab Appl Physiol & Lifestyle Med, Iowa City, IA USA.
   [Jenkins, Nathaniel D. M.] Univ Iowa, Abboud Cardiovasc Res Ctr, Iowa City, IA USA.
   [Jenkins, Nathaniel D. M.] Univ Iowa, Dept Hlth & Human Physiol, E118,Field House Bldg, Iowa City, IA 52242 USA.
C3 University of Iowa; University of Iowa; University of Iowa
RP Jenkins, NDM (corresponding author), Univ Iowa, Dept Hlth & Human Physiol, E118,Field House Bldg, Iowa City, IA 52242 USA.
EM nathaniel-jenkins@uiowa.edu
RI Banks, Nile/MVU-2974-2025; Jenkins, Nathaniel/GSE-4503-2022; Jenkins,
   Nathaniel/C-3496-2013
OI Jenkins, Nathaniel/0000-0003-1781-3414
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NR 167
TC 16
Z9 17
U1 1
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1520-7552
EI 1520-7560
J9 DIABETES-METAB RES
JI Diabetes-Metab. Res. Rev.
PD FEB
PY 2024
VL 40
IS 2
DI 10.1002/dmrr.3667
EA JUN 2023
PG 27
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA MP4B4
UT WOS:000998841400001
PM 37269143
OA hybrid
DA 2025-06-11
ER

PT J
AU Pereira, CV
   Lebiedzinska, M
   Wieckowski, MR
   Oliveira, PJ
AF Pereira, Claudia V.
   Lebiedzinska, Magda
   Wieckowski, Mariusz R.
   Oliveira, Paulo J.
TI Regulation and protection of mitochondrial physiology by sirtuins
SO MITOCHONDRION
LA English
DT Review
DE Mitochondria; Sirtuins; Toxicology; Oxidative stress; Metabolism
ID FATTY-ACID OXIDATION; FOXO TRANSCRIPTION FACTORS; IN-SITU HYBRIDIZATION;
   CALORIE RESTRICTION; INSULIN-SECRETION; SIR2 HOMOLOG; SIRT3-MEDIATED
   DEACETYLATION; CHROMOSOMAL ORGANIZATION; HISTONE DEACETYLASE;
   ENZYMATIC-ACTIVITY
AB The link between sirtuin activity and mitochondrial biology has recently emerged as an important field. This conserved family of NAD(+)-dependent deacetylase proteins has been described to be particularly involved in metabolism and longevity. Recent studies on protein acetylation have uncovered a high number of acetylated mitochondrial proteins indicating that acetylation/deacetylation processes may be important not only for the regulation of mitochondrial homeostasis but also for metabolic dysfunction in the context of various diseases such as metabolic syndrome/diabetes and cancer. The functional involvement of sirtuins as sensors of the redox/nutritional state of mitochondria and their role in mitochondrial protection against stress are hereby described, suggesting that pharmacological manipulation of sirtuins is a viable strategy against several pathologies. (C) 2011 Elsevier B.V. and Mitochondria Research Society. All rights reserved.
C1 [Pereira, Claudia V.; Oliveira, Paulo J.] Univ Coimbra, CNC Ctr Neurosci & Cell Biol, P-3004517 Coimbra, Portugal.
   [Lebiedzinska, Magda; Wieckowski, Mariusz R.] M Nencki Inst Expt Biol, PL-02093 Warsaw, Poland.
C3 Universidade de Coimbra; Polish Academy of Sciences; Nencki Institute of
   Experimental Biology of the Polish Academy of Sciences
RP Oliveira, PJ (corresponding author), Univ Coimbra, Ctr Neurosci & Cell Biol, P-3004517 Coimbra, Portugal.
EM pauloliv@ci.uc.pt
RI Lebiedzińska-Arciszewska, Magdalena/AAC-5956-2021; Oliveira,
   Paulo/AAQ-8943-2020; Wieckowski, Mariusz/ABF-1565-2022; Oliveira,
   Paulo/H-1980-2011
OI Lebiedzinska-Arciszewska, Magdalena/0000-0002-2725-5551; Wieckowski,
   Mariusz/0000-0003-0789-4521; Oliveira, Paulo/0000-0002-5201-9948
FU Portuguese Foundation for Science and Technology (FCT)
   [PTDC/SAU-TOX/110952/2009]; FCT [SFRH/BD/48029/2008]; Polish Ministry of
   Science and Higher Education [NN407 075 137]; Fundação para a Ciência e
   a Tecnologia [SFRH/BD/48029/2008, PTDC/SAU-TOX/110952/2009] Funding
   Source: FCT
FX Work in the authors' laboratory is funded by the Portuguese Foundation
   for Science and Technology (FCT) (research grant
   PTDC/SAU-TOX/110952/2009 to Paulo Oliveira). Claudia Pereira is the
   recipient of a Ph.D. fellowship from the FCT (SFRH/BD/48029/2008). The
   work was also partially supported by the Polish Ministry of Science and
   Higher Education under grant NN407 075 137 for Magda Lebiedzinsk and
   Mariusz R. Wieckowski.
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NR 139
TC 29
Z9 44
U1 0
U2 21
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1567-7249
EI 1872-8278
J9 MITOCHONDRION
JI Mitochondrion
PD JAN
PY 2012
VL 12
IS 1
SI SI
BP 66
EP 76
DI 10.1016/j.mito.2011.07.003
PG 11
WC Cell Biology; Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Genetics & Heredity
GA 895FS
UT WOS:000300482200009
PM 21787885
DA 2025-06-11
ER

PT J
AU Ostojic, MS
   Maas, J
AF Ostojic, Mladena Simeunovic
   Maas, Joyce
TI Anorexia nervosa and uric acid beyond gout: An idea worth researching
SO INTERNATIONAL JOURNAL OF EATING DISORDERS
LA English
DT Article
DE anorexia nervosa; gout; hyperuricemia; uric acid
ID COMPARATIVE PHYSIOLOGY; METABOLIC SYNDROME; BIPOLAR DISORDER; OXIDATIVE
   STRESS; EATING DISORDERS; ANTIOXIDANT; METAANALYSIS; SERUM; STARVATION;
   PARADOX
AB Uric acid is best known for its role in goutthe most prevalent inflammatory arthritis in humansthat is also described as an unusual complication of anorexia nervosa (AN). However, beyond gout, uric acid could also be involved in the pathophysiology and psychopathology of AN, as it has many biological functions serving as a pro- and antioxidant, neuroprotector, neurostimulant, and activator of the immune response. Further, recent research suggests that uric acid could be a biomarker of mood dysfunction, personality traits, and behavioral patterns. This article discusses the hypothesis that uric acid in AN may not be a mere innocent bystander determined solely by AN behavior and its medical complications. In contrast, the relation between uric acid and AN may have evolutionary origin and may be reciprocal, where uric acid regulates some features and pathophysiological processes of AN, including weight and metabolism regulation, oxidative stress, immunity, mood, cognition, and (hyper)activity.
C1 [Ostojic, Mladena Simeunovic; Maas, Joyce] Mental Hlth Ctr Reg Oost Brabant, Ctr Eating Disorders Helmond, Wesselmanlaan 25a, NL-5707 HA Helmond, Netherlands.
   [Maas, Joyce] Tilburg Univ, Dept Med & Clin Psychol, Warandelaan 2,POB 90153, NL-5000 LE Tilburg, Netherlands.
C3 Tilburg University
RP Ostojic, MS (corresponding author), Mental Hlth Ctr Reg Oost Brabant, Ctr Eating Disorders Helmond, Wesselmanlaan 25a, NL-5707 HA Helmond, Netherlands.
EM m.simeunovic-ostojic@ggzoostbrabant.nl
RI Maas, Joyce/D-6097-2012
OI Maas, Joyce/0000-0001-8049-8942
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NR 37
TC 14
Z9 14
U1 2
U2 16
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0276-3478
EI 1098-108X
J9 INT J EAT DISORDER
JI Int. J. Eating Disord.
PD FEB
PY 2018
VL 51
IS 2
BP 97
EP 101
DI 10.1002/eat.22817
PG 5
WC Psychology, Clinical; Nutrition & Dietetics; Psychiatry; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Nutrition & Dietetics; Psychiatry
GA FU8YB
UT WOS:000424141300001
PM 29314231
DA 2025-06-11
ER

PT J
AU Aldred, S
AF Aldred, Sarah
TI Oxidative and nitrative changes seen in lipoproteins following exercise
SO ATHEROSCLEROSIS
LA English
DT Review
DE low density lipoprotein; oxidative stress; antioxidant; lipid
   peroxidation
ID LOW-DENSITY-LIPOPROTEIN; LIPID-PEROXIDATION; ANTIOXIDANT STATUS;
   OXIDIZED-LDL; EXHAUSTIVE EXERCISE; OXIDANT STRESS; NITRIC-OXIDE;
   PLATELET RESPONSIVENESS; CARDIOVASCULAR-DISEASE; POSSIBLE INVOLVEMENT
AB Oxidative damage to lipoproteins, in particular low density lipoprotein (LDL), is known to play a role in a number of diseases associated with ageing such as cardiovascular disease, atherosclerosis, arthritis, dementia and the metabolic syndrome. Physical activity or exercise can alter the balance of oxidative and anti-oxidative species within the human body. A number of studies have assessed the effect of exercise training or a single exercise bout on plasma lipid oxidation or nitration, protein oxidation and circulating lipoprotein oxidation, but results are extremely mixed and the message arising from current literature in regard to exercise and its effect upon the oxidative status of lipoproteins is somewhat confusing. This review aims to summarise the studies investigating the effect of exercise on lipoprotein oxidation and nitration, and highlight areas in need of future research. (c) 2007 Elsevier Ireland Ltd. All rights reserved.
C1 Univ Birmingham, Sch Sport & Exercise Sci, Birmingham B15 2TT, W Midlands, England.
C3 University of Birmingham
RP Aldred, S (corresponding author), Univ Birmingham, Sch Sport & Exercise Sci, Birmingham B15 2TT, W Midlands, England.
EM s.aldred.1@bham.ac.uk
RI Aldred, Sarah/Z-3125-2019
OI Aldred, Sarah/0000-0002-4889-8716
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NR 91
TC 31
Z9 33
U1 0
U2 4
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0021-9150
EI 1879-1484
J9 ATHEROSCLEROSIS
JI Atherosclerosis
PD MAY
PY 2007
VL 192
IS 1
BP 1
EP 8
DI 10.1016/j.atherosclerosis.2007.02.001
PG 8
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 170IB
UT WOS:000246655400001
PM 17349647
DA 2025-06-11
ER

PT J
AU Dadachanji, R
   Shaikh, N
   Patil, A
   Shah, N
   Mukherjee, S
AF Dadachanji, Roshan
   Shaikh, Nuzhat
   Patil, Anushree
   Shah, Nalini
   Mukherjee, Srabani
TI PON1 promoter polymorphisms contribute to PCOS susceptibility and
   phenotypic outcomes in Indian women
SO GENE
LA English
DT Article
DE PCOS; PON1 gene; Hyperandrogenemia; Genetics; PON1 activity
ID POLYCYSTIC-OVARY-SYNDROME; TYPE-2 DIABETES-MELLITUS; INSULIN-RESISTANCE;
   PARAOXONASE 1; OXIDATIVE STRESS; METABOLIC SYNDROME; ENDOTHELIAL
   DYSFUNCTION; GENE POLYMORPHISMS; LACTONASE ACTIVITY; MEXICAN-AMERICANS
AB Polycystic ovary syndrome is a common endocrinopathy characterized by anovulatory infertility, hyperan-drogenism, insulin resistance and oxidative stress, which predisposes affected women to reproductive and cardiometabolic complications in later life. We have investigated the association of PON1 promoter polymorphisms with PCOS susceptibility, PON1 activity and its related traits in Indian women. The genotypic and allelic frequency distribution of only - 907G/C polymorphism in PON1 promoter showed significant difference between non-hyperandrogenic control and PCOS women, and was significantly associated with reduced susceptibility to PCOS, considering the recessive model. PON1 lactonase and arylesterase activities were also significantly decreased in women with PCOS compared to controls. Further, PON1 promoter polymorphisms were linked to altered insulin and testosterone levels in hyperandrogenic and non-hyperandrogenic women with PCOS. This study highlights PON1 as an important candidate gene influencing genetic pathophysiology of PCOS.
C1 [Dadachanji, Roshan; Shaikh, Nuzhat; Mukherjee, Srabani] Natl Inst Res Reprod Hlth ICMR, Dept Mol Endocrinol, JM St, Bombay 400012, Maharashtra, India.
   [Patil, Anushree] Natl Inst Res Reprod Hlth ICMR, Dept Clin Res, JM St, Bombay 400012, Maharashtra, India.
   [Shah, Nalini] Seth GS Med Coll, Dept Endocrinol, Bombay 400012, Maharashtra, India.
C3 Indian Council of Medical Research (ICMR); ICMR - National Institute for
   Research in Reproductive & Child Health (NIRRCH); Indian Council of
   Medical Research (ICMR); ICMR - National Institute for Research in
   Reproductive & Child Health (NIRRCH); Seth Gordhandas Sunderdas Medical
   College & King Edward Memorial Hospital
RP Mukherjee, S (corresponding author), Natl Inst Res Reprod Hlth ICMR, Dept Mol Endocrinol, JM St, Bombay 400012, Maharashtra, India.
EM mukherjees@nirrh.res.in
RI Mukherjee, Srabani/AGZ-9170-2022
OI Shaikh, Nuzhat/0000-0001-9926-1224
FU Department of Science and Technology [SR/SO/HS-64/2010(G)]; NIRRH
   [NIRRH/RA/413/09-2016]; Indian Council of Medical Research (ICMR), New
   Delhi, India
FX This work is partially supported by Department of Science and Technology
   [SR/SO/HS-64/2010(G)], NIRRH (NIRRH/RA/413/09-2016) and Indian Council
   of Medical Research (ICMR), New Delhi, India.
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NR 73
TC 8
Z9 8
U1 0
U2 8
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-1119
EI 1879-0038
J9 GENE
JI Gene
PD JUN 30
PY 2018
VL 661
BP 34
EP 44
DI 10.1016/j.gene.2018.03.083
PG 11
WC Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Genetics & Heredity
GA GG2GH
UT WOS:000432507700004
PM 29604466
DA 2025-06-11
ER

PT J
AU Cizza, G
   Rother, KI
AF Cizza, G.
   Rother, K. I.
TI Beyond fast food and slow motion: Weighty contributors to the obesity
   epidemic
SO JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
LA English
DT Review
DE Cortisol; endocrinology; environment; individualized medicine; leptin;
   prevention; stress
ID SHORT-SLEEP DURATION; BODY-MASS INDEX; ALZHEIMERS-DISEASE; BARIATRIC
   SURGERY; PUTATIVE CONTRIBUTORS; METABOLIC SYNDROME; RISK; STRESS;
   ASSOCIATION; CHILDREN
AB Decreased physical activity and marketing-driven increased consumption of "junk" food, dubbed "The Big Two", are generally regarded as the most important contributors to the obesity epidemic. However, the full picture contains many more pieces of the puzzle. We address several additional issues and review current clinical developments in obesity research. In spite of dramatic advancements in our understanding of the adipose organ and its endocrine and immune products, the ultimate causes of the obesity epidemic remain elusive. Treatment is plagued by poor adherence to life style modifications, and available pharmacological options are marginally effective, often also associated with major side effects. Surgical treatments, albeit effective in decreasing body weight, are invasive and expensive. Thus, our approaches to finding the causes, improving the existing treatments, and inventing novel therapies must be manifold. (J. Endocrinol. Invest. 35: 236-242, 2012) (C) 2012, Editrice Kurtis
C1 [Cizza, G.] NIDDK, Sect Neuroendocrinol Obes, Ctr Clin, NIH,DHHS, Bethesda, MD USA.
   [Rother, K. I.] NIDDK, Sect Pediat Diabet & Metab, Ctr Clin, NIH,DHHS, Bethesda, MD USA.
C3 National Institutes of Health (NIH) - USA; NIH National Institute of
   Diabetes & Digestive & Kidney Diseases (NIDDK); NIH Clinical Center
   (CC); National Institutes of Health (NIH) - USA; NIH National Institute
   of Diabetes & Digestive & Kidney Diseases (NIDDK); NIH Clinical Center
   (CC)
RP Cizza, G (corresponding author), CRC, Bldg 10,Rm 6-3940, Bethesda, MD 20892 USA.
EM cizzag@intra.niddk.nih.gov
FU Intramural NIH HHS [Z99 OD999999, ZIA DK075052, Z99 DK999999, ZIA
   DK047049, Z99 DA999999, ZIA DK075053] Funding Source: Medline
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NR 94
TC 17
Z9 19
U1 0
U2 26
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0391-4097
EI 1720-8386
J9 J ENDOCRINOL INVEST
JI J. Endocrinol. Invest.
PD FEB
PY 2012
VL 35
IS 2
BP 236
EP 242
DI 10.3275/8182
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 955RU
UT WOS:000305039400020
PM 22183119
DA 2025-06-11
ER

PT J
AU Torumtay, G
   Kirzioglu, FY
   Tonguc, MÖ
   Kale, B
   Calapoglu, M
   Orhan, H
AF Torumtay, G.
   Kirzioglu, F. Y.
   Tonguc, M. Ozturk
   Kale, B.
   Calapoglu, M.
   Orhan, H.
TI Effects of periodontal treatment on inflammation and oxidative stress
   markers in patients with metabolic syndrome
SO JOURNAL OF PERIODONTAL RESEARCH
LA English
DT Article
DE chronic periodontitis; cytokines; metabolic syndrome; oxidative stress
ID GINGIVAL CREVICULAR FLUID; C-REACTIVE PROTEIN; CARDIOVASCULAR RISK;
   INSULIN-RESISTANCE; SERUM-LEVELS; THERAPY; SALIVA; ATHEROSCLEROSIS;
   DISEASE; TISSUE
AB Background and ObjectiveMetabolic syndrome (MetS) is a combination of risk factors (e.g. impaired glucose tolerance, hypertension, and dyslipidaemia) that significantly contribute to the development of cardiovascular diseases. The aim of the study was to compare the effects of nonsurgical periodontal treatment (NSPT) on inflammatory and oxidative stress markers in individuals with MetS and systemically healthy (SH) who were chronic periodontitis (CP).
   Material and MethodsA total of 50 patients with chronic periodontitis (25 with MetS and 25 SH) were included. Clinical periodontal measurements were recorded, and serum and whole-saliva samples were collected from all patients at baseline, and 3 and 6 mo following NSPT. The levels of fasting plasma glucose, glycated haemoglobin (HbA1c), triglyceride (TRG), total cholesterol, high-density lipoprotein cholesterol and low-density lipoprotein cholesterol were analysed. The levels of high-sensitivity C-reactive protein (hs-CRP), interleukin (IL)-6 and IL-10 were determined using ELISA kits, and total oxidant status (TOS), total antioxidant capacity (TAC) and oxidative stress index (OSI) levels were measured.
   ResultsAfter NSPT, significant and similar improvements of all periodontal parameters were observed in both groups compared with baseline measurements. There were decreases in the levels of serum hs-CRP and IL-6, whereas increases in serum IL-10 were found in both groups, at all time points. Serum TOS and OSI showed no significant change in either group at any time point. Compared with the SH group, serum TAC levels were higher in the MetS group at baseline but lower at the 3-mo time-point. There was no difference in TAC levels between the groups at 6 mo. Saliva IL-6 was higher in the MetS group than the SH group at all time points. The levels of IL-6 and OSI in saliva decreased following NSPT in both groups, whereas salivary TAC concentrations increased. In the MetS group, TRG and HbA1c levels decreased significantly at 3 mo.
   ConclusionNSPT decreased oxidative stress and the inflammatory status of patients with MetS and chronic periodontitis. Although similar periodontal improvements were achieved in both groups, the decreases in levels of hs-CRP and IL-6 in the MetS group did not reach the levels in the SH group. Based on these results, NSPT could be more effective in the control of systemic inflammation in patients with MetS in the short-term.
C1 [Torumtay, G.; Kirzioglu, F. Y.; Tonguc, M. Ozturk] Suleyman Demirel Univ, Fac Dent, Dept Periodontol, TR-32260 Isparta, Turkey.
   [Kale, B.] Suleyman Demirel Univ, Fac Med, Dept Internal Med, Isparta, Turkey.
   [Calapoglu, M.] Suleyman Demirel Univ, Dept Biochem, Fac Arts & Sci, Isparta, Turkey.
   [Orhan, H.] Suleyman Demirel Univ, Dept Biostat & Med Informat, Fac Med, Isparta, Turkey.
C3 Suleyman Demirel University; Suleyman Demirel University; Suleyman
   Demirel University; Suleyman Demirel University
RP Kirzioglu, FY (corresponding author), Suleyman Demirel Univ, Fac Dent, Dept Periodontol, TR-32260 Isparta, Turkey.
EM yesimkirzioglu@sdu.edu.tr
RI Ozturk Tonguc, Mine/ABB-8905-2022; Calapoglu, mustafa/AAA-8756-2022;
   Torumtay Cin, Gizem/LMN-0806-2024; Orhan, Hikmet/A-1089-2016; KIRZIOĞLU,
   Fatma Yeşim/AGQ-2082-2022
OI Torumtay Cin, Gizem/0000-0002-5362-4146; KALE, BANU/0000-0001-6268-0927
FU Unit of Scientific Research Projects, Suleyman Demirel University,
   Isparta, Turkey [3244-D1-12]
FX The authors are grateful to the Unit of Scientific Research Projects,
   Suleyman Demirel University, Isparta, Turkey for providing financial
   support for this research (project number 3244-D1-12). The authors
   report no conflicts of interest related to this study.
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NR 57
TC 45
Z9 48
U1 0
U2 30
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-3484
EI 1600-0765
J9 J PERIODONTAL RES
JI J. Periodont. Res.
PD AUG
PY 2016
VL 51
IS 4
BP 489
EP 498
DI 10.1111/jre.12328
PG 10
WC Dentistry, Oral Surgery & Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dentistry, Oral Surgery & Medicine
GA DR5AH
UT WOS:000379914800008
PM 26547140
OA Bronze
DA 2025-06-11
ER

PT J
AU Gan, L
   Liu, ZJ
   Luo, D
   Ren, Q
   Wu, H
   Li, CX
   Sun, C
AF Gan, Lu
   Liu, Zhenjiang
   Luo, Dan
   Ren, Qian
   Wu, Hua
   Li, Changxing
   Sun, Chao
TI Reduced Endoplasmic Reticulum Stress-Mediated Autophagy Is Required for
   Leptin Alleviating Inflammation in Adipose Tissue
SO FRONTIERS IN IMMUNOLOGY
LA English
DT Article
DE leptin; endoplasmic reticulum stress; autophagy; Atf4/Atg5;
   inflammation; adipocyte
ID UNFOLDED PROTEIN RESPONSE; FATTY-ACID OXIDATION; ER STRESS; KAPPA-B;
   ENDOTHELIAL DYSFUNCTION; MITOCHONDRIAL CLEARANCE; METABOLIC HOMEOSTASIS;
   INSULIN SENSITIVITY; MICE ADIPOCYTES; BODY-WEIGHT
AB Leptin is an adipocyte-derived hormone and maintains adipose function under challenged conditions. Autophagy is also essential to maintain cellular homeostasis and regulate characteristics of adipose tissue. However, the effects of leptin on autophagy of adipocyte remain elusive. Here, we demonstrated endoplasmic reticulum (ER) stress and leptin were correlated with autophagy and inflammation by transcriptome sequencing of adipose tissue. Leptin-mediated inhibition of autophagy was involved in upstream reduction of ER stress proteins such as Chop, GRP78, and Atf4, since blockage of autophagy using pharmacological approach had no effect on tunicamycin-induced ER stress. Moreover, we determined KLF4, the potential transcriptional factor of Atf4, was required for the leptin-mediated autophagy in the regulation of adipocyte inflammation. Importantly, ATF4 physically interacted with ATG5 and subsequently formed a complex to promote adipocyte autophagy. Further analysis revealed that Atg5, a core component of autophagosome, was the target for leptin-mediate autophagy. In addition, leptin alleviated ER stress-induced inflammation by reducing autophagy-mediated degradation of I kappa B in adipocytes. Exogenous leptin treatment also ameliorated autophagy and inflammation of white adipose tissue in ob/ob mice. Taken together, our results indicated that leptin inhibited ER stress-mediated autophagy and inflammation through the negatively regulation of Atf4/Atg5 complex in adipocytes. These findings identify a new potential means for intervention of autophagy to prevent or treat obese caused metabolic syndrome of mammals.
C1 [Gan, Lu; Liu, Zhenjiang; Luo, Dan; Ren, Qian; Wu, Hua; Li, Changxing; Sun, Chao] Northwest A&F Univ, Coll Anim Sci & Technol, Yangling, Peoples R China.
C3 Northwest A&F University - China
RP Sun, C (corresponding author), Northwest A&F Univ, Coll Anim Sci & Technol, Yangling, Peoples R China.
EM sunchao2775@163.com
RI Luo, Dan/HZM-2412-2023; Chen, Lingling/JCD-4631-2023; Gan,
   Lu/JXX-1314-2024; ren, qian/ABE-4426-2021
FU Major National Scientific Research Projects [2015CB943102]; National
   Nature Science Foundation of China [31572365]; Key Sci-tech innovation
   team of Shaanxi province [2017KCT-24]
FX This work was supported by the Major National Scientific Research
   Projects under Grant 2015CB943102; and the National Nature Science
   Foundation of China under Grant 31572365; and the Key Sci-tech
   innovation team of Shaanxi province under Grant 2017KCT-24.
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NR 80
TC 34
Z9 39
U1 0
U2 20
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA PO BOX 110, EPFL INNOVATION PARK, BUILDING I, LAUSANNE, 1015,
   SWITZERLAND
SN 1664-3224
J9 FRONT IMMUNOL
JI Front. Immunol.
PD NOV 8
PY 2017
VL 8
AR 1507
DI 10.3389/fimmu.2017.01507
PG 17
WC Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology
GA FM0HN
UT WOS:000414643600001
PM 29250056
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Santos, CXC
   Nabeebaccus, AA
   Shah, AM
   Camargo, LL
   Filho, SV
   Lopes, LR
AF Santos, Celio X. C.
   Nabeebaccus, Adam A.
   Shah, Ajay M.
   Camargo, Livia L.
   Filho, Sidney V.
   Lopes, Lucia R.
TI Endoplasmic Reticulum Stress and Nox-Mediated Reactive Oxygen Species
   Signaling in the Peripheral Vasculature: Potential Role in Hypertension
SO ANTIOXIDANTS & REDOX SIGNALING
LA English
DT Review
ID PROTEIN DISULFIDE-ISOMERASE; CONTROLS PHAGOSOMAL PH; OXIDATIVE STRESS;
   NADPH OXIDASES; INSULIN-RESISTANCE; ANGIOTENSIN-II; NAD(P)H OXIDASE;
   HEXOSE-6-PHOSPHATE DEHYDROGENASE; MOLECULAR-MECHANISMS; METABOLIC
   SYNDROME
AB Significance: Reactive oxygen species (ROS) are produced during normal endoplasmic reticulum (ER) metabolism. There is accumulating evidence showing that under stress conditions such as ER stress, ROS production is increased via enzymes of the NADPH oxidase (Nox) family, especially via the Nox2 and Nox4 isoforms, which are involved in the regulation of blood pressure. Hypertension is a major contributor to cardiovascular and renal disease, and it has a complex pathophysiology involving the heart, kidney, brain, vessels, and immune system. ER stress activates the unfolded protein response (UPR) signaling pathway that has prosurvival and proapoptotic components. Recent Advances: Here, we summarize the evidence regarding the association of Nox enzymes and ER stress, and its potential contribution in the setting of hypertension, including the role of other conditions that can lead to hypertension (e.g., insulin resistance and diabetes). Critical Issues: A better understanding of this association is currently of great interest, as it will provide further insights into the cellular mechanisms that can drive the ER stress-induced adaptive versus maladaptive pathways linked to hypertension and other cardiovascular conditions. More needs to be learnt about the precise signaling regulation of Nox(es) and ER stress in the cardiovascular system. Future Directions: The development of specific approaches that target individual Nox isoforms and the UPR signaling pathway may be important for the achievement of therapeutic efficacy in hypertension. Antioxid. Redox Signal. 20, 121-134.
C1 [Santos, Celio X. C.; Nabeebaccus, Adam A.; Shah, Ajay M.] British Heart Fdn, Kings Coll London, Ctr Excellence, Cardiovasc Div, London SE5 9NU, England.
   [Camargo, Livia L.; Filho, Sidney V.; Lopes, Lucia R.] Univ Sao Paulo, Inst Biomed Sci, Dept Pharmacol, Redox Signaling Lab, Sao Paulo, Brazil.
C3 University of London; University College London; King's College London;
   Universidade de Sao Paulo; Institute Biomed Science, University Sao
   Paulo
RP Santos, CXC (corresponding author), British Heart Fdn, Kings Coll London, James Black Ctr, Ctr Excellence,Cardiovasc Div, 125 Coldharbour Lane, London SE5 9NU, England.
EM celioxcs@yahoo.com.br
RI Shah, Amy/AAB-4631-2020; Lopes, Lucia/JAC-3855-2023; Filho,
   Sidney/W-4632-2019; Lopes, Lucia/B-9063-2012
OI Shah, Ajay/0000-0002-6547-0631; de Lucca Camargo,
   Livia/0000-0002-7451-7147; Lopes, Lucia/0000-0003-0530-7805
FU British Heart Foundation [RG/08/011/25922, CH/99001, RE/08/003]; Leducq
   Foundation Transatlantic Network of Excellence award; National Institute
   for Health Research comprehensive Biomedical Research Centre award; UK
   Medical Research Council Clinical Research Training Fellowship
   [G1100441]; Fundacao de Amparo a Pesquisa do Estado de Sao Paulo
   (FAPESP); Conselho Nacional de Desenvolvimento Cientifico e Tecnologico
   (CNPq); Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior
   (CAPES); MRC [G1100441] Funding Source: UKRI
FX C.X.C.S. and A.M.S. are supported by the British Heart Foundation
   (RG/08/011/25922; CH/99001; RE/08/003), a Leducq Foundation
   Transatlantic Network of Excellence award, and a National Institute for
   Health Research comprehensive Biomedical Research Centre award to Guy's
   & St Thomas' NHS Foundation Trust in partnership with King's College
   London and King's College Hospital NHS Foundation Trust. A.A.N. is
   supported by a UK Medical Research Council Clinical Research Training
   Fellowship (G1100441). L.R.L. is supported by Fundacao de Amparo a
   Pesquisa do Estado de Sao Paulo (FAPESP) and Conselho Nacional de
   Desenvolvimento Cientifico e Tecnologico (CNPq). L.L.C. is supported by
   Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES).
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NR 120
TC 116
Z9 127
U1 0
U2 18
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1523-0864
EI 1557-7716
J9 ANTIOXID REDOX SIGN
JI Antioxid. Redox Signal.
PD JAN 1
PY 2014
VL 20
IS 1
BP 121
EP 134
DI 10.1089/ars.2013.5262
PG 14
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 284XU
UT WOS:000329356300009
PM 23472786
OA Green Published
DA 2025-06-11
ER

PT J
AU Wang, NN
   Liu, Y
   Ma, YN
   Wen, DL
AF Wang, Ningning
   Liu, Yang
   Ma, Yanan
   Wen, Deliang
TI Hydroxytyrosol ameliorates insulin resistance by modulating endoplasmic
   reticulum stress and prevents hepatic steatosis in diet-induced obesity
   mice
SO JOURNAL OF NUTRITIONAL BIOCHEMISTRY
LA English
DT Article
DE Hydroxytyrosol; Olive oil; Obesity; Endoplasmic reticulum stress;
   Insulin resistance; Liver steatosis
ID INDUCED METABOLIC SYNDROME; UNFOLDED PROTEIN RESPONSE; ADIPOSE-TISSUE;
   ER STRESS; RAT MODEL; ACTIVATION; APOPTOSIS; DYSREGULATION;
   INFLAMMATION; EXPRESSION
AB Endoplasmic reticulum (ER) is a principal organelle responsible for energy and nutrient management. Its dysfunction has been viewed in the context of obesity and related glucolipid metabolic disorders. However, therapeutic approaches to improve ER adaptation and systemic energy balance in obesity are limited. Thus, we examined whether hydroxytyrosol (HT), an important polyphenolic compound found in virgin olive oil, could correct the metabolic impairments in diet-induced obesity (DIO) mice. Here, we found that HT gavage for 10 weeks significantly ameliorated glucose homeostasis and chronic inflammation and decreased hepatic steatosis in DIO mice. At the molecular level, ER stress indicators, inflammatory and insulin signaling markers demonstrated that high-fat diet (HFD)-induced ER stress and insulin resistance (IR) in insulin sensitive tissue were corrected by HT. In vitro studies confirmed that HT supplementation (100 mu M) attenuated palmitate-evoked ER stress, thus rescuing the downstream JNK/IRS pathway. As a result from suppression of ER stress in the liver, HT further decreased hepatic sterol regulatory element-binding protein-1 expression (SREBP1). Additionally, aberrant expression of genes involved in hepatic lipogenesis (SREBP1, ACC, FAS, SCD1) caused by HFD was restored by HT. These findings suggested that HT ameliorated chronic inflammation and IR and decreased hepatic steatosis in obesity by beneficial modulation of ER stress. (C) 2018 Elsevier Inc. All rights reserved.
C1 [Wang, Ningning] Dalian Med Univ, Sch Publ Hlth, Dalian, Liaoning, Peoples R China.
   [Liu, Yang; Ma, Yanan; Wen, Deliang] China Med Univ, Sch Publ Hlth, Shenyang, Liaoning, Peoples R China.
C3 Dalian Medical University; China Medical University
RP Wen, DL (corresponding author), China Med Univ, 77 Puhe Rd, Shenyang, Liaoning, Peoples R China.
EM dlwen@cmu.edu.cn
RI Wang, Ningning/KCX-7219-2024
FU National Natural Science Foundation of China [71774173]; Liaoning
   Distinguished Professor (Liao taught) [204]
FX This research project was funded by National Natural Science Foundation
   of China (71774173) and Liaoning Distinguished Professor (Liao taught
   (2013) No. 204).
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NR 44
TC 48
Z9 52
U1 1
U2 32
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0955-2863
EI 1873-4847
J9 J NUTR BIOCHEM
JI J. Nutr. Biochem.
PD JUL
PY 2018
VL 57
BP 180
EP 188
DI 10.1016/j.jnutbio.2018.03.018
PG 9
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA GM5MJ
UT WOS:000438181200020
PM 29747118
DA 2025-06-11
ER

PT J
AU Briet, M
   Schiffrin, EL
AF Briet, Marie
   Schiffrin, Ernesto L.
TI Vascular Actions of Aldosterone
SO JOURNAL OF VASCULAR RESEARCH
LA English
DT Review
DE Arteries; Vascular stiffness; Remodeling; Vasoconstriction; Endothelial
   dysfunction; Inflammation; Oxidative stress; Genomic and nongenomic
   effects
ID ANGIOTENSIN-II RECEPTORS; ENDOTHELIAL DYSFUNCTION; SYNTHASE INHIBITOR;
   INTRACELLULAR CA2+; INSULIN-RESISTANCE; BLOOD-PRESSURE; RHO-KINASE;
   SPIRONOLACTONE; CELLS; HEART
AB Aldosterone exerts direct effects on the vascular system by inducing oxidative stress, inflammation, hypertrophic remodeling, fibrosis, and endothelial dysfunction. Aldosterone exerts its effects through genomic and nongenomic pathways in a mineralocorticoid receptor (MR)-dependent or independent manner. Other aldosterone receptors such as GPR30 have been identified. A tight relation exists between the aldosterone and angiotensin II pathways, as well as with the endothelin-1 system. There is a correlation between plasma levels of aldosterone and cardiovascular risk. Recently, an increasing body of evidence has underlined the importance of aldosterone in cardiovascular complications associated with the metabolic syndrome, such as arterial remodeling and endothelial dysfunction. Blockade of MR is an increasingly used evidence-based therapy for many forms of cardiovascular disease, including hypertension, heart failure, chronic kidney disease, and diabetes mellitus. Copyright (c) 2012 S. Karger AG, Basel
C1 [Briet, Marie] Univ Paris 05, Hop Europeen Georges Pompidou, Assistance Publ Hop Paris, Fac Med,INSERM CIC 9201, Paris, France.
   [Schiffrin, Ernesto L.] Sir Mortimer B Davis Jewish Hosp, Dept Med, Montreal, PQ, Canada.
   [Schiffrin, Ernesto L.] McGill Univ, Lady Davis Inst Med Res, Montreal, PQ, Canada.
C3 Institut National de la Sante et de la Recherche Medicale (Inserm);
   Universite Paris Cite; Assistance Publique Hopitaux Paris (APHP);
   Hopital Universitaire Saint-Louis - APHP; Hopital Universitaire Europeen
   Georges-Pompidou - APHP; Jewish General Hospital - Montreal; Lady Davis
   Institute; McGill University
RP Schiffrin, EL (corresponding author), SMBD Jewish Gen Hosp, Dept Med, B-127 3755 Cote Ste Catherine Rd, Montreal, PQ H3T 1E2, Canada.
EM ernesto.schiffrin@mcgill.ca
RI Briet, Marie/K-7385-2015; Schiffrin, Ernesto/AAB-9061-2019
OI Briet, Marie/0000-0003-3738-5998; Schiffrin, Ernesto/0000-0002-4502-2823
FU Canadian Institutes of Health Research (CIHR) [37917, 82790, 102606];
   Canada Research Chair on Hypertension and Vascular Research from
   CIHR/Government of Canada; Canada Fund for Innovation; Heart and Stroke
   Foundation of Canada
FX The work of E.L.S. was supported by Canadian Institutes of Health
   Research (CIHR) grants 37917, 82790, and 102606, a Canada Research Chair
   on Hypertension and Vascular Research from CIHR/Government of Canada,
   and the Canada Fund for Innovation. M.B. was supported by a fellowship
   from the Heart and Stroke Foundation of Canada.
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NR 86
TC 135
Z9 145
U1 0
U2 23
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1018-1172
EI 1423-0135
J9 J VASC RES
JI J. Vasc. Res.
PY 2013
VL 50
IS 2
BP 89
EP 99
DI 10.1159/000345243
PG 11
WC Physiology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology; Cardiovascular System & Cardiology
GA 090RA
UT WOS:000314995500001
PM 23172373
OA Bronze
DA 2025-06-11
ER

PT J
AU Galatou, E
   Mourelatou, E
   Hatziantoniou, S
   Vizirianakis, IS
AF Galatou, Eleftheria
   Mourelatou, Elena
   Hatziantoniou, Sophia
   Vizirianakis, Ioannis S.
TI Nonalcoholic Steatohepatitis (NASH) and Atherosclerosis: Explaining
   Their Pathophysiology, Association and the Role of Incretin-Based Drugs
SO ANTIOXIDANTS
LA English
DT Review
DE nonalcoholic steatohepatitis (NASH); nonalcoholic fatty liver disease
   (NAFLD); atherosclerosis; inflammation; oxidative stress; GLP-1 RAs;
   DPP4-i; incretin-based drugs; cardiovascular outcome trial (CVOT);
   lipotoxicity
ID FATTY LIVER-DISEASE; GLUCAGON-LIKE PEPTIDE-1; CAROTID-ARTERY
   ATHEROSCLEROSIS; HEPATIC STELLATE CELLS; DE-NOVO LIPOGENESIS;
   CARDIOVASCULAR-DISEASE; ENDOTHELIAL DYSFUNCTION; MOLECULAR-MECHANISMS;
   DENSITY-LIPOPROTEIN; METABOLIC SYNDROME
AB Nonalcoholic steatohepatitis (NASH) is the most severe manifestation of nonalcoholic fatty liver disease (NAFLD), a common complication of type 2 diabetes, and may lead to cirrhosis and hepatocellular carcinoma. Oxidative stress and liver cell damage are the major triggers of the severe hepatic inflammation that characterizes NASH, which is highly correlated with atherosclerosis and coronary artery disease. Regarding drug therapy, research on the role of GLP-1 analogues and DPP4 inhibitors, novel classes of antidiabetic drugs, is growing. In this review, we outline the association between NASH and atherosclerosis, the underlying molecular mechanisms, and the effects of incretin-based drugs, especially GLP-1 RAs, for the therapeutic management of these conditions.
C1 [Galatou, Eleftheria; Mourelatou, Elena; Vizirianakis, Ioannis S.] Univ Nicosia, Sch Sci & Engn, Dept Life & Hlth Sci, CY-2417 Nicosia, Cyprus.
   [Hatziantoniou, Sophia] Univ Patras, Sch Hlth Sci, Dept Pharm, Lab Pharmaceut Technol, Patras 26504, Greece.
   [Vizirianakis, Ioannis S.] Aristotle Univ Thessaloniki, Sch Pharm, Pharmacol Lab, Thessaloniki 54124, Greece.
C3 University of Nicosia; University of Patras; Aristotle University of
   Thessaloniki
RP Galatou, E; Mourelatou, E (corresponding author), Univ Nicosia, Sch Sci & Engn, Dept Life & Hlth Sci, CY-2417 Nicosia, Cyprus.
EM galatou.e@unic.ac.cy; mourelatou.e@unic.ac.cy; sohatzi@upatras.gr;
   ivizir@pharm.auth.gr
RI Vizirianakis, Ioannis/AAK-5795-2020
OI Hatziantoniou, Sophia/0000-0002-5877-9091; Vizirianakis,
   Ioannis/0000-0003-1459-9774; GALATOU, ELEFTHERIA/0000-0002-5395-7573
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NR 178
TC 9
Z9 9
U1 0
U2 21
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD JUN
PY 2022
VL 11
IS 6
AR 1060
DI 10.3390/antiox11061060
PG 30
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA 2N2BY
UT WOS:000818192500001
PM 35739957
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Zhao, JJ
   Chen, HL
   Liu, N
   Chen, J
   Gu, YQ
   Chen, JJ
   Yang, K
AF Zhao, Junjie
   Chen, Hailin
   Liu, Ning
   Chen, Jun
   Gu, Youquan
   Chen, Jiangjun
   Yang, Kui
TI Role of Hyperhomocysteinemia and Hyperuricemia in Pathogenesis of
   Atherosclerosis
SO JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
LA English
DT Review
DE Hyperhomocysteinemia; hyperuricemia; atherosclerosis; mechanisms
ID NITRIC-OXIDE PRODUCTION; ENDOPLASMIC-RETICULUM STRESS;
   ENDOTHELIAL-CELLS; URIC-ACID; CARDIOVASCULAR-DISEASE; VASCULAR-DISEASE;
   HOMOCYSTEINE; INFLAMMATION; DYSFUNCTION; METAANALYSIS
AB Background: The mechanisms of hyperhomocysteinemia (HHcy) and hyperuricemia (HUA) that promote atherosclerosis were seldom explored and always indefinite. Therefore, we will discuss some new reviews about the role of HHcy and HUA in the pathogenesis of atherosclerosis. Methods: This study was conducted by reading a lot of literature, including basic research and clinical application research. Results: HHcy is known as an independent risk factor for atherosclerosis. Possible mechanisms for the association between homocysteine and atherosclerosis include stimulating smooth muscle cell growth, reducing endothelial cell growth and endothelial cell relaxation, and decreasing synthesis of high-density lipoprotein. HUA causes endothelial dysfunction and thereby increases oxidative stress, inducing vascular smooth muscle cell proliferation and reducing endothelial nitric oxide bioavailability. HUA plays a role in the development and pathogenesis of metabolic syndrome, hypertension, stroke, and atherosclerosis. Conclusions: Accelerated atherosclerosis may be a consequence of the combined effect of HHcy and HUA.
C1 [Zhao, Junjie; Chen, Hailin; Liu, Ning; Chen, Jun; Gu, Youquan; Chen, Jiangjun; Yang, Kui] Zhoukou Cent Hosp, Dept Neurol, Zhoukou 466000, Henan, Peoples R China.
RP Liu, N (corresponding author), Lanzhou Univ, Clin Med Coll, Dept Neurol, Lanzhou 730000, Gansu, Peoples R China.
EM Lnning1957@sina.com
RI Liu, Ning/H-7705-2017; Zhao, Junjie/GPW-7378-2022
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NR 39
TC 90
Z9 106
U1 0
U2 46
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1052-3057
EI 1532-8511
J9 J STROKE CEREBROVASC
JI J. Stroke Cerebrovasc. Dis.
PD DEC
PY 2017
VL 26
IS 12
BP 2695
EP 2699
DI 10.1016/j.jstrokecerebrovasdis.2016.10.012
PG 5
WC Neurosciences; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Cardiovascular System & Cardiology
GA FO9IY
UT WOS:000417202400003
PM 28986198
DA 2025-06-11
ER

PT J
AU Kelishadi, R
   Poursafa, P
AF Kelishadi, Roya
   Poursafa, Parinaz
TI Air pollution and non-respiratory health hazards for children
SO ARCHIVES OF MEDICAL SCIENCE
LA English
DT Review
DE air pollution; children; health; prevention; chronic disease; public
   health
ID LOW-BIRTH-WEIGHT; POSTNEONATAL INFANT-MORTALITY; VITAMIN-D DEFICIENCY;
   METABOLIC SYNDROME; CARDIOVASCULAR-DISEASE; DEVELOPING-COUNTRIES;
   CHILDHOOD LEUKEMIA; OXIDATIVE STRESS; SOCIOECONOMIC POSITION;
   RESIDENTIAL EXPOSURE
AB Air pollution is a global health issue with serious public health implications, particularly for children Usually respiratory effects of air pollutants are considered, but this review highlights the importance of non-respiratory health hazards In addition to short-term effects, exposure to criteria air pollutants from early life might be associated with low birth weight, increase in oxidative stress and endothelial dysfunction, which in turn might have long-term effects on chronic non-communicable diseases In view of the emerging epidemic of chronic disease in low- and middle- income countries, the vicious cycle of rapid urbanization and increasing levels of air pollution, public health and regulatory policies for air quality protection should be integrated into the main priorities of the primary health care system and into the educational curriculum of health professionals
C1 [Kelishadi, Roya] Isfahan Univ Med Sci, Isfahan Cardiovasc Res Ctr, Esfahan, Iran.
   [Poursafa, Parinaz] Sci & Res Univ, Tehran, Iran.
C3 Isfahan University of Medical Sciences
RP Kelishadi, R (corresponding author), Isfahan Univ Med Sci, Isfahan Cardiovasc Res Ctr, POB 81465-1148, Esfahan, Iran.
RI Poursafa, Parinaz/U-2924-2017; Kelishadi, Roya/E-6154-2012
OI Poursafa, Parinaz/0000-0002-8067-4122; Kelishadi,
   Roya/0000-0001-7455-1495
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   BEYOND EC GROWTH
NR 79
TC 78
Z9 82
U1 0
U2 33
PU TERMEDIA PUBLISHING HOUSE LTD
PI POZNAN
PA KLEEBERGA ST 2, POZNAN, 61-615, POLAND
SN 1734-1922
EI 1896-9151
J9 ARCH MED SCI
JI Arch. Med. Sci.
PD AUG
PY 2010
VL 6
IS 4
BP 483
EP 495
DI 10.5114/aoms.2010.14458
PG 13
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 646UA
UT WOS:000281567300003
PM 22371790
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Liu, L
   Tang, L
   Luo, JM
   Chen, SY
   Yi, CY
   Liu, XM
   Hu, CH
AF Liu, Lu
   Tang, Lei
   Luo, Jia-ming
   Chen, Si-yu
   Yi, Chun-yan
   Liu, Xue-mei
   Hu, Chang-hua
TI Activation of the PERK-CHOP signaling pathway during endoplasmic
   reticulum stress contributes to olanzapine-induced dyslipidemia
SO ACTA PHARMACOLOGICA SINICA
LA English
DT Article
DE antipsychotic drug; olanzapine; lipid metabolism disorder; endoplasmic
   reticulum stress; SREBPs; PERK-CHOP signaling pathway
ID LIPOGENIC GENE-EXPRESSION; ANTIPSYCHOTIC-DRUGS; METABOLIC SYNDROME; ER
   STRESS; SCHIZOPHRENIA; MECHANISMS; OBESITY; PEOPLE; SERUM
AB Olanzapine (OLZ) is a widely prescribed antipsychotic drug with a relatively ideal effect in the treatment of schizophrenia (SCZ). However, its severe metabolic side effects often deteriorate clinical therapeutic compliance and mental rehabilitation. The peripheral mechanism of OLZ-induced metabolic disorders remains abstruse for its muti-target activities. Endoplasmic reticulum (ER) stress is implicated in cellular energy metabolism and the progression of psychiatric disorders. In this study, we investigated the role of ER stress in the development of OLZ-induced dyslipidemia. A cohort of 146 SCZ patients receiving OLZ monotherapy was recruited, and blood samples and clinical data were collected at baseline, and in the 4th week, 12th week, and 24th week of the treatment. This case-control study revealed that OLZ treatment significantly elevated serum levels of endoplasmic reticulum (ER) stress markers GRP78, ATF4, and CHOP in SCZ patients with dyslipidemia. In HepG2 cells, treatment with OLZ (25, 50 mu M) dose-dependently enhanced hepatic de novo lipogenesis accompanied by SREBPs activation, and simultaneously triggered ER stress. Inhibition of ER stress by tauroursodeoxycholate (TUDCA) and 4-phenyl butyric acid (4-PBA) attenuated OLZ-induced lipid dysregulation in vitro and in vivo. Moreover, we demonstrated that activation of PERK-CHOP signaling during ER stress was a major contributor to OLZ-triggered abnormal lipid metabolism in the liver, suggesting that PERK could be a potential target for ameliorating the development of OLZ-mediated lipid dysfunction. Taken together, ER stress inhibitors could be a potentially effective intervention against OLZ-induced dyslipidemia in SCZ.
C1 [Liu, Lu; Liu, Xue-mei; Hu, Chang-hua] Southwest Univ, Med Res Inst, Sch Pharmaceut Sci, Chongqing 400715, Peoples R China.
   [Liu, Lu; Liu, Xue-mei; Hu, Chang-hua] NMPA Key Lab Qual Monitoring Narcot Drugs & Psycho, Chongqing 400715, Peoples R China.
   [Liu, Lu; Tang, Lei; Luo, Jia-ming] North Sichuan Med Coll, Sch Mental Hlth, Nanchong 637100, Peoples R China.
   [Tang, Lei; Luo, Jia-ming] North Sichuan Med Coll, Mental Hlth Ctr, Affiliated Hosp, Nanchong 637100, Peoples R China.
   [Chen, Si-yu; Yi, Chun-yan] North Sichuan Med Coll, Affiliated Nanchong Psychosomat Hosp, Nanchong 637100, Peoples R China.
C3 Southwest University - China; North Sichuan Medical University; North
   Sichuan Medical University; North Sichuan Medical University
RP Hu, CH (corresponding author), Southwest Univ, Med Res Inst, Sch Pharmaceut Sci, Chongqing 400715, Peoples R China.; Hu, CH (corresponding author), NMPA Key Lab Qual Monitoring Narcot Drugs & Psycho, Chongqing 400715, Peoples R China.
EM chhhu@swu.edu.cn
RI YANG, DAN/KCL-5217-2024; tang, lei/JCO-4117-2023; Chen, Siyu/I-9386-2019
OI Luo, Jiaming/0000-0003-0025-0379
FU This study was supported by the Chongqing Basic Research and Frontier
   Exploration Project (cstc2022ycjh-bgzxm0119). [cstc2022ycjh-bgzxm0119];
   Chongqing Basic Research and Frontier Exploration Project
FX This study was supported by the Chongqing Basic Research and Frontier
   Exploration Project (cstc2022ycjh-bgzxm0119).
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NR 62
TC 5
Z9 5
U1 1
U2 11
PU NATURE PUBL GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1671-4083
EI 1745-7254
J9 ACTA PHARMACOL SIN
JI Acta Pharmacol. Sin.
PD MAR
PY 2024
VL 45
IS 3
BP 502
EP 516
DI 10.1038/s41401-023-01180-w
EA OCT 2023
PG 15
WC Chemistry, Multidisciplinary; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Pharmacology & Pharmacy
GA GJ7S3
UT WOS:001088867100001
PM 37880338
DA 2025-06-11
ER

PT J
AU Tamashiro, KLK
   Nguyen, MMN
   Ostrander, MM
   Gardner, SR
   Ma, LY
   Woods, SC
   Sakai, RR
AF Tamashiro, Kellie L. K.
   Nguyen, Mary M. N.
   Ostrander, Michelle M.
   Gardner, Stacy R.
   Ma, Li Yun
   Woods, Stephen C.
   Sakai, Randall R.
TI Social stress and recovery: implications for body weight and body
   composition
SO AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE
   PHYSIOLOGY
LA English
DT Article
DE food intake; fat distribution; obesity; metabolic syndrome; Visible;
   Burrow System
ID FEMALE CYNOMOLGUS MONKEYS; VISIBLE BURROW SYSTEM; MIDDLE-AGED MEN;
   CORONARY-ARTERY ATHEROSCLEROSIS; FAT DISTRIBUTION; VISCERAL OBESITY;
   MALE-RATS; METABOLIC COMPLICATIONS; SUBORDINATION STRESS; PSYCHOSOCIAL
   STRESS
AB Social stress resulting from dominant-subordinate relationships is associated with body weight loss and altered body composition in subordinate ( SUB) male rats. Here, we extend these findings to determine whether stress-induced changes in energy homeostasis persist when the social stress is removed, and the animal is allowed to recover. We examined body weight (BW), body composition, and relevant endocrine measures after one or two cycles of 14 days of social stress, each followed by 21 days of recovery in each rat's individual home cage. SUB lost significantly more BW during social housing in a visible burrow system (VBS) compared with dominant (DOM) animals. Weight loss during social stress was attributable to a decrease in adipose tissue in DOM and SUB, with an additional loss of lean tissue in SUB. During both 21-day recovery periods, DOM and SUB regained lost BW, but only SUB were hyperphagic. Following recovery, SUB had a relatively larger increase in adipose tissue and plasma leptin compared with DOM, indicating that body composition changes were dependent on social status. Control animals that were weight matched to SUB or male rats exposed to the VBS environment without females, and that did not form a social hierarchy, did not exhibit changes in body composition like SUB in the VBS. Therefore, chronic social stress causes social status-dependent changes in BW, composition and endocrine measures that persist after repeated stress and recovery cycles and that may ultimately lead to metabolic disorders and obesity.
C1 Univ Cincinnati, Med Ctr, Grad Program Neurosci, Cincinnati, OH 45267 USA.
   Univ Cincinnati, Med Ctr, Dept Psychiat, Cincinnati, OH 45267 USA.
C3 University System of Ohio; University of Cincinnati; University System
   of Ohio; University of Cincinnati
RP Sakai, RR (corresponding author), Univ Cincinnati, Genome Res Inst, Dept Psychiat N, 2170 E Galbraith Rd,2nd Floor, Cincinnati, OH 45237 USA.
EM randall.sakai@uc.edu
OI Tamashiro, Kellie/0000-0002-9398-8796
FU NIDDK NIH HHS [DK-017844, DK-066596, DK-059803] Funding Source: Medline;
   NINDS NIH HHS [F31 NS047791, NS-047791] Funding Source: Medline
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NR 58
TC 97
Z9 108
U1 0
U2 17
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0363-6119
J9 AM J PHYSIOL-REG I
JI Am. J. Physiol.-Regul. Integr. Comp. Physiol.
PD NOV
PY 2007
VL 293
IS 5
BP R1864
EP R1874
DI 10.1152/ajpregu.00371.2007
PG 11
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA 227OU
UT WOS:000250668300010
PM 17855491
DA 2025-06-11
ER

PT J
AU Hillard, CJ
   Weinlander, KM
   Stuhr, KL
AF Hillard, C. J.
   Weinlander, K. M.
   Stuhr, K. L.
TI CONTRIBUTIONS OF ENDOCANNABINOID SIGNALING TO PSYCHIATRIC DISORDERS IN
   HUMANS: GENETIC AND BIOCHEMICAL EVIDENCE
SO NEUROSCIENCE
LA English
DT Review
DE endocannabinoid; CNR1; fatty acid amide hydrolase; plasma; serum; FAAH
ID CANNABINOID RECEPTOR GENE; ACID-AMIDE-HYDROLASE;
   POSTTRAUMATIC-STRESS-DISORDER; CARDIOMETABOLIC RISK-FACTORS; ANTERIOR
   CINGULATE CORTEX; MESSENGER-RNA EXPRESSION; 1 CNR1 GENE; ENDOGENOUS
   CANNABINOIDS; CB1 RECEPTORS; ADENYLATE-CYCLASE
AB The endocannabinoid signaling system is a widespread, neuromodulatory system in brain and is also widely utilized in the periphery to modulate metabolic functions and the immune system. Preclinical data demonstrate that endocannabinoid signaling is an important stress buffer and modulates emotional and cognitive functions. These data suggest the hypothesis that endocannabinoid signaling could be dysfunctional in a number of mental disorders. Genetic polymorphisms in the human genes for two important proteins of the endocannabinoid signaling system, the CBI cannabinoid receptor (CB1R) and fatty acid amide hydrolase (FAAH), have been explored in the context of normal and pathological conditions. In the case of the gene for FAAH, the mechanistic relationships among the common genetic polymorphism, the expression of the FAAH protein, and its likely impact on endocannabinoid signaling are understood. However, multiple polymorphisms in the gene for the CB1R occur and are associated with human phenotypic differences without an understanding of the functional relationships among the gene, mRNA, protein, and protein function. The endocannabinoid ligands are found in the circulation, and several studies have identified changes in their concentrations under various conditions. These data are reviewed for the purpose of generating hypotheses and to encourage further studies in this very interesting and important area.
   This article is part of a Special Issue entitled: Stress, Emotional Behavior and the Endocannabinoid System. (C) 2011 IBRO. Published by Elsevier Ltd. All rights reserved.
C1 [Hillard, C. J.] Med Coll Wisconsin, Dept Pharmacol, Milwaukee, WI 53226 USA.
   Med Coll Wisconsin, Neurosci Res Ctr, Milwaukee, WI 53226 USA.
C3 Medical College of Wisconsin; Medical College of Wisconsin
RP Hillard, CJ (corresponding author), Med Coll Wisconsin, Dept Pharmacol, Milwaukee, WI 53226 USA.
EM chillard@mcw.edu
RI Hillard, Cecilia/O-6693-2018
OI Hillard, Cecilia/0000-0002-9678-748X
FU NIH [R01DA09155, R01DA026996]
FX The authors were supported during the writing of this review by NIH
   grants R01DA09155 and R01DA026996.
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   Zuo L, 2009, NEUROPSYCHOPHARMACOL, V34, P1504, DOI 10.1038/npp.2008.206
NR 236
TC 131
Z9 146
U1 1
U2 15
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4522
EI 1873-7544
J9 NEUROSCIENCE
JI Neuroscience
PD MAR 1
PY 2012
VL 204
SI SI
BP 207
EP 229
DI 10.1016/j.neuroscience.2011.11.020
PG 23
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 906FT
UT WOS:000301331000019
PM 22123166
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Joaquim, L
   Faria, A
   Loureiro, H
   Matafome, P
AF Joaquim, Lisandra
   Faria, Ana
   Loureiro, Helena
   Matafome, Paulo
TI Benefits, mechanisms, and risks of intermittent fasting in metabolic
   syndrome and type 2 diabetes
SO JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
LA English
DT Review
DE Intermittent fasting; Insulin resistance; Glucose; Diabetes
ID CALORIC RESTRICTION; INSULIN-RESISTANCE; OXIDATIVE STRESS; GLUCOSE;
   OBESITY; HEALTH; PROTEIN; YOUNG; TIME; MASS
AB One of the emergent nutritional strategies for improving multiple features of cardiometabolic diseases is the practice of intermittent fasting (IF), which consists of alternating periods of eating and fasting. IF can reduce circulating glucose and insulin levels, fat mass, and the risk of developing age-related pathologies. IF appears to upregulate evolution-conserved adaptive cellular responses, such as stress-response pathways, autophagy, and mitochondrial function. IF was also observed to modulate the circadian rhythms of hormones like insulin or leptin, among others, which levels change in conditions of food abundance and deficit. However, some contradictory results regarding the duration of the interventions and the anterior metabolic status of the participants suggest that more and longer studies are needed in order to draw conclusions. This review summarizes the current knowledge regarding the role of IF in the modulation of mechanisms involved in type 2 diabetes, as well as the risks.
C1 [Joaquim, Lisandra; Faria, Ana; Loureiro, Helena; Matafome, Paulo] Inst Politecn Coimbra, Coimbra Hlth Sch ESTeSC, Coimbra, Portugal.
   [Matafome, Paulo] Univ Coimbra, Fac Med, Inst Clin & Biomed Res iCBR, Subunit 1, 1st Floor,Azinhaga Santa Comba, P-3000354 Coimbra, Portugal.
   [Matafome, Paulo] Univ Coimbra, Ctr Innovat Biomed & Biotechnol CIBB, Coimbra, Portugal.
   [Matafome, Paulo] Clin Acad Ctr, Coimbra, Portugal.
C3 Instituto Politecnico de Coimbra (IPC); Universidade de Coimbra;
   Universidade de Coimbra
RP Matafome, P (corresponding author), Inst Politecn Coimbra, Coimbra Hlth Sch ESTeSC, Coimbra, Portugal.; Matafome, P (corresponding author), Univ Coimbra, Fac Med, Inst Clin & Biomed Res iCBR, Subunit 1, 1st Floor,Azinhaga Santa Comba, P-3000354 Coimbra, Portugal.; Matafome, P (corresponding author), Univ Coimbra, Ctr Innovat Biomed & Biotechnol CIBB, Coimbra, Portugal.; Matafome, P (corresponding author), Clin Acad Ctr, Coimbra, Portugal.
EM paulo.matafome@uc.pt
RI LOUREIRO, MARIA/GZL-0404-2022; Matafome, Paulo/AAQ-4113-2020; Faria,
   Ana/ABY-7778-2022
OI Loureiro, Helena/0000-0003-1892-9013; Matafome,
   Paulo/0000-0002-3422-290X; Faria, Ana/0000-0002-9125-7690
FU Portuguese Science and Technology Foundation (FCT) [UIDB/04539/2020]
FX This work was supported by the Portuguese Science and Technology
   Foundation (FCT): Strategic Project UIDB/04539/2020 (CIBB).
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NR 77
TC 19
Z9 21
U1 2
U2 47
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1138-7548
EI 1877-8755
J9 J PHYSIOL BIOCHEM
JI J. Physiol. Biochem.
PD MAY
PY 2022
VL 78
IS 2
BP 295
EP 305
DI 10.1007/s13105-021-00839-4
EA JAN 2022
PG 11
WC Biochemistry & Molecular Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Physiology
GA 2O2AI
UT WOS:000739301300002
PM 34985730
DA 2025-06-11
ER

PT J
AU Singhal, SS
   Garg, R
   Horne, D
   Singhal, S
   Awasthi, S
   Salgia, R
AF Singhal, Sharad S.
   Garg, Rachana
   Horne, David
   Singhal, Sulabh
   Awasthi, Sanjay
   Salgia, Ravi
TI RLIP: A necessary transporter protein for translating oxidative stress
   into pro-obesity and pro-carcinogenic signaling
SO BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
LA English
DT Review
DE RLIP; p53; Cancer; diabetes; obesity; drug resistance; Mercapturic acid
   pathway
ID ENDOPLASMIC-RETICULUM STRESS; RAL-BINDING PROTEIN-1; METABOLIC SYNDROME;
   DEPENDENT TRANSPORT; CARDIOVASCULAR RISK; CANCER; EPIDEMIOLOGY; MICE;
   INFLAMMATION; EFFECTOR
AB Previously, we showed that knockout mice homozygous for deficiency of the mercapturic acid pathway (MAP) transporter protein, RLIP (RLIP-/-), are resistant to chemical carcinogenesis, inflammation, and metabolic syndrome (MetS). We also found that RLIP-/-mice are highly resistant to obesity caused by a high-fat diet (HFD). Interestingly, these studies showed that kinase, cytokine, and adipokine signaling that are characteristics of obesity were blocked despite the presence of increased oxidative stress in RLIP-/-mice. The deficiencies in obesity-inducing kinase, cytokine, and adipokine signaling were attributable to a lack of clathrin-dependent endocytosis (CDE), a process that is severely deficient in RLIP-/-mice. Because CDE is also necessary for carcinogenic signaling through EGF, WNT, TGFI3 and other cancer-specific peptide hormones, and because RLIP-/-mice are cancer-resistant, we reasoned that depletion of RLIP by an antisense approach should cause cancer regression in human cancer xenografts. This prediction has been confirmed in studies of xenografts from lung, kidney, prostate, breast, and pancreatic cancers and melanoma. Because these results suggested an essential role for RLIP in carcinogenesis, and because our studies have also revealed a direct interaction between p53 and RLIP, we reasoned that if RLIP played a central role in carcinogenesis, that development of lymphoma in p53 -/-mice, which normally occurs by the time these mice are 6 months old, could be delayed or prevented by depleting RLIP. Recent studies described herein have confirmed this hypothesis, showing complete suppression of lymphomagenesis in p53-/-mice treated with anti-RLIP antisense until the age of 8 months. All control mice developed lymphoma in the thymus or testis as expected. These findings lead to a novel paradigm predicting that under conditions of increased oxidative stress, the consequent increased flux of metabolites in the MAP causes a proportional increase in the rate of CDE. Because CDE inhibits insulin and TNF signaling but promotes EGF, TGFI3, and Wnt signaling, our model predicts that chronic stress-induced increases in RLIP (and consequently CDE) will induce insulin-resistance and enhance predisposition to cancer. Alternatively, generalized depletion of RLIP would antagonize the growth of malignant cells, and concomitantly exert therapeutic insulin-sensitizing effects. Therefore, this review focuses on how targeted depletion or inhibition of RLIP could provide a novel target for treating both obesity and cancer.
C1 [Singhal, Sharad S.; Salgia, Ravi] City Hope Natl Med Ctr, Comprehens Canc Ctr, Dept Med Oncol & Therapeut Res, Beckman Res Inst, Duarte, CA 91010 USA.
   [Singhal, Sharad S.; Garg, Rachana; Horne, David; Salgia, Ravi] Natl Med Ctr, Duarte, CA 91010 USA.
   [Garg, Rachana] City Hope Natl Med Ctr, Comprehens Canc Ctr, Beckman Res Inst, Dept Surg, Duarte, CA 91010 USA.
   [Horne, David] City Hope Natl Med Ctr, Comprehens Canc Ctr, Beckman Res Inst, Dept Mol Med, Duarte, CA 91010 USA.
   [Singhal, Sulabh] Drexel Univ, Coll Med, Philadelphia, PA 19129 USA.
   [Awasthi, Sanjay] CTMH Doctors Hosp Cayman Islands, Cayman Hlth, George Town, Cayman Islands.
C3 City of Hope; Beckman Research Institute of City of Hope; City of Hope;
   City of Hope; Beckman Research Institute of City of Hope; City of Hope;
   Beckman Research Institute of City of Hope; Drexel University
RP Singhal, SS (corresponding author), City Hope Natl Med Ctr, Comprehens Canc Ctr, Dept Med Oncol & Therapeut Res, Beckman Res Inst, Duarte, CA 91010 USA.; Singhal, SS (corresponding author), Natl Med Ctr, Duarte, CA 91010 USA.
EM ssinghal@coh.org
RI Singhal, Ashutosh/H-6725-2019
FU United States Department of Defense; National Cancer Institute of the
   Na-tional Institutes of Health; Beckman Research Institute of the City
   of Hope;  [W81XWH-16-1-0641];  [W81XWH-20-1-0362];  [W81XWH-22-0331]; 
   [P30CA33572]
FX Funding This work was partly supported by grants from the United States
   Department of Defense (W81XWH-16-1-0641, W81XWH-20-1-0362, and
   W81XWH-22-0331) and the National Cancer Institute of the Na-tional
   Institutes of Health (P30CA33572) . Funding from the Beckman Research
   Institute of the City of Hope is also acknowledged.
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NR 81
TC 7
Z9 7
U1 0
U2 1
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0304-419X
EI 1879-2561
J9 BBA-REV CANCER
JI Biochim. Biophys. Acta-Rev. Cancer
PD SEP
PY 2022
VL 1877
IS 5
AR 188803
DI 10.1016/j.bbcan.2022.188803
EA SEP 2022
PG 9
WC Biochemistry & Molecular Biology; Biophysics; Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Oncology
GA 5D0UT
UT WOS:000864667000008
PM 36150564
OA Bronze
DA 2025-06-11
ER

PT J
AU Coquart, JB
   Boitel, G
   Borel, B
   Duhamel, A
   Matran, R
   Delsart, P
   Mounier-Vehier, C
   Garcin, M
AF Coquart, Jeremy B.
   Boitel, Guillaume
   Borel, Benoit
   Duhamel, Alain
   Matran, Regis
   Delsart, Pascal
   Mounier-Vehier, Claire
   Garcin, Murielle
TI Exercise training at the crossover point improves bodily and
   cardiorespiratory data but not quality of life in women with metabolic
   syndrome
SO JOURNAL OF SPORTS MEDICINE AND PHYSICAL FITNESS
LA English
DT Article
DE Quality of life; Obesity; Indirect calorimetry; Substrate cycling;
   Oxygen consumption
ID CARDIOVASCULAR-DISEASE; MORTALITY; OXIDATION; OBESITY; IMPACT; RISK
AB BACKGROUND: This study investigated the effects of an exercise program at the intensity corresponding to the crossover point of substrate utilization (COP) on anthropometric measures, health-related quality of life (HRQoL) and cardiorespiratory fitness (i.e., peak oxygen uptake [(V)over dotO(2peak) and peak power output [P-peak) in women with metabolic syndrome (MetS).
   METHODS: Nineteen obese and post-menopausal women with MetS (age: 54.8 +/- 8.1 years, body mass: 89.0 +/- 12.2 kg, Body Mass Index: 34.5 +/- 4.0 kg/m(2)) followed a 12-week program consisting of three 45-minute sessions per week of cycle ergometer exercise. The imposed exercise intensity corresponded to COP. Before and after the program, HRQoL, (V)over dotO(2peak) and P-peak were measured and then compared.
   RESULTS: Body mass (89.0 +/- 12.2 vs. 86.2 +/- 11.0 kg), Body Mass Index (34.5 +/- 4.0 vs. 33.4 +/- 3.6 kg/m(2)), waist (10 +/- 10 vs. 100 +/- 9 cm) and hip (117 +/- 11 vs. 114 +/- 11 cm) circumferences, waist-to-hip ratio (0.91 +/- 0.07 vs. 0.88 +/- 0.07), fat mass (43.3 +/- 4.6 vs. 41.9 +/- 4.6%), fat-free mass (56.7 +/- 4.6 vs. 58.2 +/- 4.6%), (V)over dotO(2peak) (16.6 +/- 3.4 vs. 18.1 +/- 4.1 mL/min/kg) and P-peak (102 +/- 22 vs. 125 +/- 27 W) were significantly improved after the exercise program (P<0.05), but HRQoL showed no significant improvement on any subscale (i.e., physical functioning: performance limitation for physical activities including bathing and dressing, role physical: problems with work or other daily activities, bodily pain, general health, vitality, social functioning, role emotional and mental health; P>0.05).
   CONCLUSIONS: Although a 12-week exercise program at COP improved anthropometric measures and cardiorespiratory fitness in women with MetS, self-perceived HRQoL did not significantly improve. This finding may be linked to a significant but still insufficient reduction in body mass, probably because COP is too weak exercise intensity to induce important energy expenditure.
C1 [Coquart, Jeremy B.] Univ Rouen, CETAPS, EA 3832, Mont St Aignan, France.
   [Boitel, Guillaume; Matran, Regis; Garcin, Murielle] Univ Lille, Lille, France.
   [Boitel, Guillaume; Garcin, Murielle] UDSL, EA4488, Ronchin, France.
   [Borel, Benoit] Univ Limoges, HAVAE, EA 6310, Limoges, France.
   [Duhamel, Alain] Univ Lille, Dept BioStat, EA 2694, Lille, France.
   [Matran, Regis] Ctr Hosp Univ Lille, Serv Explorat Fonctionnelles & Respiratoires, Lille, France.
   [Delsart, Pascal; Mounier-Vehier, Claire] Ctr Hosp Univ Lille, Serv Med Vasc & Hypertens Arterielle, Lille, France.
C3 Universite de Rouen Normandie; Universite de Lille; Universite de Lille;
   Universite de Limoges; Universite de Lille; Universite de Lille; CHU
   Lille; Universite de Lille; CHU Lille
RP Coquart, JB (corresponding author), Univ Rouen, CETAPS, EA 3832, Mont St Aignan, France.
EM jeremy.coquart@yahoo.com
RI Duhamel, Alain/B-8624-2011; Coquart, Jeremy/I-3657-2019; Mounier-Vehier
   nee Vacheron, Claire/JKJ-1608-2023; Garcin, Murielle/L-5221-2018
OI Mounier-Vehier nee Vacheron, Claire/0000-0001-9407-0701; Garcin,
   Murielle/0000-0002-7476-6063; Coquart, Jeremy/0000-0001-6515-7736
FU Contrat de Plan Etat-Region "Diabete: du syndrome metabolique aux
   complications vasculaires", France
FX This study received financial support from the Contrat de Plan
   Etat-Region "Diabete: du syndrome metabolique aux complications
   vasculaires", France.
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SC Sport Sciences
GA EQ5NN
UT WOS:000398129700017
PM 26364689
DA 2025-06-11
ER

PT J
AU Papakonstantinou, I
   Tsioufis, K
   Katsi, V
AF Papakonstantinou, Ilias
   Tsioufis, Konstantinos
   Katsi, Vasiliki
TI Spotlight on the Mechanism of Action of Semaglutide
SO CURRENT ISSUES IN MOLECULAR BIOLOGY
LA English
DT Review
DE semaglutide; adipose; browning; diabetes; obesity; inflammation;
   autophagy; infections; aging; sarcopenia
ID GLUCAGON-LIKE PEPTIDE-1; ADIPOSE-TISSUE; RECEPTOR AGONISTS; OXIDATIVE
   STRESS; OBESITY; BROWN; LEPTIN; FAT; WEIGHT; PATHOGENESIS
AB Initially intended to control blood glucose levels in patients with type 2 diabetes, semaglutide, a potent glucagon-like peptide 1 analogue, has been established as an effective weight loss treatment by controlling appetite. Integrating the latest clinical trials, semaglutide in patients with or without diabetes presents significant therapeutic efficacy in ameliorating cardiometabolic risk factors and physical functioning, independent of body weight reduction. Semaglutide may modulate adipose tissue browning, which enhances human metabolism and exhibits possible benefits in skeletal muscle degeneration, accelerated by obesity and ageing. This may be attributed to anti-inflammatory, mitochondrial biogenesis, antioxidant and autophagy-regulating effects. However, most of the supporting evidence on the mechanistic actions of semaglutide is preclinical, demonstrated in rodents and not actually confirmed in humans, therefore warranting caution in the interpretation. This article aims to explore potential innovative molecular mechanisms of semaglutide action in restoring the balance of several interlinking aspects of metabolism, pointing to distinct functions in inflammation and oxidative stress in insulin-sensitive musculoskeletal and adipose tissues. Moreover, possible applications in protection from infections and anti-aging properties are discussed. Semaglutide enhancement of the core molecular mechanisms involved in the progress of obesity and diabetes, although mostly preclinical, may provide a framework for future research applications in human diseases overall.
C1 [Papakonstantinou, Ilias] Evangelismos Gen Hosp, Dept Internal Med 4, Athens 10676, Greece.
   [Tsioufis, Konstantinos; Katsi, Vasiliki] Natl & Kapodistrian Univ Athens, Hippokrat Gen Hosp, Sch Med, Dept Cardiol 1, Athens 11527, Greece.
C3 Evangelismos Hospital; National & Kapodistrian University of Athens;
   Athens Medical School
RP Papakonstantinou, I (corresponding author), Evangelismos Gen Hosp, Dept Internal Med 4, Athens 10676, Greece.; Katsi, V (corresponding author), Natl & Kapodistrian Univ Athens, Hippokrat Gen Hosp, Sch Med, Dept Cardiol 1, Athens 11527, Greece.
EM iliaspapacon@yahoo.gr; ktsioufis@gmail.com; vkkatsi@yahoo.gr
OI Papakonstantinou, Ilias/0000-0002-3148-9342
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NR 206
TC 1
Z9 1
U1 13
U2 13
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1467-3037
EI 1467-3045
J9 CURR ISSUES MOL BIOL
JI Curr. Issues Mol. Biol.
PD DEC
PY 2024
VL 46
IS 12
BP 14514
EP 14541
DI 10.3390/cimb46120872
PG 28
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA Q3O1O
UT WOS:001383809400001
PM 39728000
OA gold
DA 2025-06-11
ER

PT J
AU Williams, J
   Stubbs, B
   Gaughran, F
   Craig, T
AF Williams, Julie
   Stubbs, Brendon
   Gaughran, Fiona
   Craig, Tom
TI 'Walk This Way' - a pilot of a health coaching intervention to reduce
   sedentary behaviour and increase low intensity exercise in people with
   serious mental illness: study protocol for a randomised controlled trial
SO TRIALS
LA English
DT Article
DE Sedentary behaviour; Physical activity; Serious mental illness;
   Psychosis; Metabolic syndrome
ID MAJOR DEPRESSIVE DISORDER; TYPE-2 DIABETES-MELLITUS; PHYSICAL-ACTIVITY;
   METABOLIC SYNDROME; BIPOLAR DISORDER; SCHIZOPHRENIA; PREVALENCE;
   MORTALITY; RISK; QUESTIONNAIRE
AB Background: People with serious mental illness (SMI) (psychosis, bipolar disorder and major depressive disorder) experience a considerable risk of premature mortality because of cardiovascular disease. Recent research has demonstrated that this population spends almost 13 h per day being sedentary. Sedentary behaviour is an independent risk factor for cardiovascular disease and mortality. Given the potential for physical activity to improve health and well-being in people with SMI, we developed a pilot randomised controlled trial (RCT) to evaluate a coaching intervention aimed at reducing sedentary behaviour and increasing physical activity in people with SMI. Our primary aim was to assess the acceptability and feasibility of the intervention. Secondary aims were to see if the Walk This Way (WTW) intervention decreased sedentary behaviour and increased activity levels.
   Methods/design: People with SMI who met any of the following criteria were recruited by two community mental health teams in South London: (1) overweight, (2) at risk for or have diabetes, (3) smoke tobacco or (4) have a sedentary lifestyle. Care co-coordinators (clinical case managers) identified potentially eligible participants within their caseload, and these individuals were subsequently invited to participate. All participants' physical activity (self-reported and accelerometer-recorded), health status (including metabolic blood tests) and motivation to exercise were assessed at baseline. Participants were randomised to receive treatment as usual or the WTW intervention. WTW consisted of an educational intervention at baseline on the benefits of an active lifestyle. Participants were then given a pedometer and received fortnightly coaching from a staff member trained in coaching skills to help them to set daily walking targets, and they were invited to a weekly walking group. The WTW intervention lasted 17 weeks in total.
   Discussion: To our knowledge, WTW is the first RCT to investigate the impact of a health coaching intervention targeting sedentary behaviour in people with SMI. It is hoped that if the intervention is feasible and acceptable, further large scale study can be developed and implemented in routine care.
C1 [Williams, Julie; Stubbs, Brendon; Craig, Tom] Kings Coll London, Inst Psychiat Psychol & Neurosci, Hlth Serv & Populat Res Dept, London SE5 8AF, England.
   [Williams, Julie; Stubbs, Brendon; Gaughran, Fiona; Craig, Tom] CLAHRC, South London, England.
   [Stubbs, Brendon] South London & Maudsley NHS Fdn Trust, Physiotherapy Dept, Denmark Hill, London SE5 8AZ, England.
   [Gaughran, Fiona] Kings Coll London, Inst Psychiat Psychol & Neurosci, Psychosis Studies, London, England.
   [Gaughran, Fiona] South London & Maudsley NHS Fdn Trust, Natl Psychosis Serv, London, England.
C3 University of London; King's College London; University of London;
   King's College London; South London & Maudsley NHS Trust
RP Williams, J (corresponding author), Kings Coll London, Inst Psychiat Psychol & Neurosci, Hlth Serv & Populat Res Dept, London SE5 8AF, England.; Williams, J (corresponding author), CLAHRC, South London, England.
EM julie.williams@kcl.ac.uk
RI Stubbs, Brendon/X-1904-2018; Gaughran, Fiona/AAC-7160-2019; Williams,
   Julie/JYQ-5874-2024; Stubbs, Brendon/C-5696-2015; Gaughran,
   Fiona/H-5495-2011
OI Williams, Julie/0000-0002-8861-0596; Stubbs,
   Brendon/0000-0001-7387-3791; Gaughran, Fiona/0000-0001-7414-5569
FU National Institute for Health Research (NIHR) Collaboration for
   Leadership in Applied Health Research and Care South London at King's
   College Hospital NHS Foundation Trust
FX This research was funded by the National Institute for Health Research
   (NIHR) Collaboration for Leadership in Applied Health Research and Care
   South London at King's College Hospital NHS Foundation Trust. The views
   expressed are those of the authors and not necessarily those of the NHS,
   the NIHR or the Department of Health.
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NR 37
TC 14
Z9 14
U1 0
U2 27
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1745-6215
J9 TRIALS
JI Trials
PD DEC 12
PY 2016
VL 17
AR 594
DI 10.1186/s13063-016-1660-2
PG 8
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Research & Experimental Medicine
GA EF5SE
UT WOS:000390389100006
PM 27955680
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Hellerstein, DJ
   Almeida, G
   Devlin, MJ
   Mendelsohn, N
   Helfand, S
   Dragatsi, D
   Miranda, R
   Kelso, JR
   Capitelli, L
AF Hellerstein, David J.
   Almeida, Goretti
   Devlin, Michael J.
   Mendelsohn, Nathaniel
   Helfand, Stacia
   Dragatsi, Dianna
   Miranda, Raquel
   Kelso, Julie R.
   Capitelli, Lucia
TI Assessing obesity and other related health problems of mentally ill
   Hispanic patients in an urban outpatient setting
SO PSYCHIATRIC QUARTERLY
LA English
DT Article
DE schizophrenia; obesity; atypical antipsychotics; metabolic syndrome;
   Latino patients; community psychiatry
ID BODY-MASS INDEX; WEIGHT-GAIN; MYOCARDIAL-INFARCTION; METABOLIC SYNDROME;
   52 COUNTRIES; SCHIZOPHRENIA; ACCULTURATION; INDIVIDUALS; PREVALENCE;
   OLANZAPINE
AB Objective This paper describes the role of an agency Clinical Director in developing a project to assess and begin to address obesity-related health problems of patients treated in a community-based mental health clinic in New York City. After a five year review of outpatient deaths revealed a high rate of deaths from cardiovascular and diabetes-related issues, the Clinical Director assembled a group of clinicians, researchers, and administrative staff to design a pilot project to assess health and nutrition status of primarily Hispanic day treatment patients with severe and persistent mental illness.
   Method About 69 of the 105 patients at the clinic were assessed by chart review, interview about nutritional habits and medical care, and somatic measurements for blood pressure, weight, girth, body mass index (BMI), glucose and lipid levels.
   Results Patients were predominantly between the ages of 25 and 64 years, 51% were female, and 78% were Hispanic. Around 57% were diagnosed with schizophrenia-spectrum disorders, 86% were receiving antipsychotic medications, and 25% were on two or more antipsychotics. Only 11% of the women and 41% of the men had normal weight. A total of 29% of the women and 18% of the men were overweight (BMI = 25-29.9); and an additional 60% of the women and 41% of the men were obese (BMI >= 30). Atypical antipsychotic treatment was significantly associated with obesity (BMI >= 30) (chi sq = 5.5, df = 1, P < 0.025). Using American Heart Association criteria, waist measurements showed significant abdominal obesity among female patients. Blood pressure was elevated in 77% of the patients: 45% were pre-hypertensive with BP 120-139/80-89 and 32% were hypertensive with BP >= 140/90. About 53% had elevated random blood glucoses (> 110 mg/dl). On the positive side, patients generally had had recent medical follow-up, and most had adequate cooking facilities.
   Conclusions This project revealed that these predominantly Hispanic, severely mentally ill individuals were at high risk for cardiac illness, highlighting the need for developing culturally-sensitive interventions in urban outpatient psychiatric settings. Findings were disseminated in educational presentations and clinical discussions, and have mobilized an institutional effort to significantly improve medical monitoring for these patients.
C1 New York State Psychiat Inst & Hosp, New York, NY 10032 USA.
   Columbia Univ, Teachers Coll, New York, NY 10027 USA.
C3 New York State Psychiatry Institute; Columbia University Teachers
   College; Columbia University
RP Hellerstein, DJ (corresponding author), New York State Psychiat Inst & Hosp, Harkness Pavil,Room HP256,180 Ft Washington Ave, New York, NY 10032 USA.
EM hellers@pi.cpmc.columbia.edu
OI Hellerstein, David/0000-0002-8031-4354
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NR 35
TC 18
Z9 26
U1 0
U2 6
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0033-2720
EI 1573-6709
J9 PSYCHIAT QUART
JI Psychiatr. Q.
PD SEP
PY 2007
VL 78
IS 3
BP 171
EP 181
DI 10.1007/s11126-007-9038-y
PG 11
WC Psychiatry
WE Social Science Citation Index (SSCI)
SC Psychiatry
GA 191VM
UT WOS:000248160100002
PM 17417734
DA 2025-06-11
ER

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AF Mahato, Binod
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TI Factors Influencing Prevalence, C-reactive Protein Levels, and
   Lymphocyte Counts in Chronic Obstructive Pulmonary Disease Patients With
   Metabolic Syndrome
SO CUREUS JOURNAL OF MEDICAL SCIENCE
LA English
DT Article
DE height; waist circumference; diastolic pressure; systolic pressure;
   chronic obstructive pulmonary disease; metabolic syndrome
ID CARDIOVASCULAR-DISEASE; SYSTEMIC INFLAMMATION; COPD; ASSOCIATION;
   MORTALITY; OBESITY; ADULTS; HEALTH
AB Background This research examined the relationship between C-reactive protein (CRP) levels and lymphocyte counts in individuals with chronic obstructive pulmonary disease (COPD) comparing those with metabolic syndrome (MetS) to those without. Methodology This cross-sectional study involved 100 consecutive COPD patients attending the outpatient wards at the Department of Medicine, Index Medical College, over 18 months. MetS was assessed using the International Diabetes Federation's guidelines. Pulmonary function tests such as spirometry were conducted following the European Respiratory Society's procedures, including measurements of forced expiratory volume in one second (FEV1), forced vital capacity (FVC), and the FEV1/FVC ratio. The Global Initiative for Obstructive Lung Disease criteria were employed to evaluate COPD severity using post-bronchodilator FEV1. Results Our results indicated no significant differences in demographics, anthropometrics, or pulmonary function tests between COPD patients with MetS and those without. Average age, height, weight, body mass index, and blood pressure readings were similar between the groups, with no significant variations (p > 0.05). However, the total white blood cell count was significantly higher in the MetS group (9,214 +/- 3,161.8 cells/mu L) compared to the non-MetS group (6,657.8 +/- 4,218 cells/mu L, p = 0.001). CRP levels were markedly elevated in 90.9% of MetS patients compared to 21.4% of non-MetS patients. Pulmonary function tests showed no significant differences in pre- and post-bronchodilator FEV1 or FEV1/FVC ratios (p > 0.05). Conclusions The study found that individuals with COPD and MetS have elevated levels of CRP, suggesting that this association exacerbates systemic inflammation and metabolic issues. Furthermore, the risk of MetS in COPD patients did not significantly differ between smokers and non-smokers, indicating that MetS can affect all COPD patients regardless of smoking status. Additionally, more than half of the COPD patients had hypertension, a common comorbidity that reflects the oxidative stress and inflammatory processes shared by both conditions.
C1 [Mahato, Binod; Nigoskar, Shreya] Malwanchal Univ, Hosp & Res Ctr, Index Med Coll, Dept Biochem, Indore, India.
   [Lakshmi, Lingidi Jhansi; Zephy, Doddigarla] Hitech Med Coll & Hosp, Dept Biochem, Rourkela, India.
RP Zephy, D (corresponding author), Hitech Med Coll & Hosp, Dept Biochem, Rourkela, India.
EM doddigarla.zephy@hotmail.com
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NR 29
TC 0
Z9 0
U1 0
U2 0
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
EI 2168-8184
J9 CUREUS J MED SCIENCE
JI Cureus J Med Sci
PD AUG 29
PY 2024
VL 16
IS 8
AR e68122
DI 10.7759/cureus.68122
PG 7
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA E8A9Z
UT WOS:001305187200019
PM 39347252
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Nunn, AVW
   Guy, GW
   Bell, JD
AF Nunn, Alistair V. W.
   Guy, Geoffrey W.
   Bell, Jimmy D.
TI The intelligence paradox; will ET get the metabolic syndrome? Lessons
   from and for Earth
SO NUTRITION & METABOLISM
LA English
DT Article
DE Intelligence; Obesity; Hormesis; Exercise; Metabolic syndrome; Type 2
   diabetes; Environment; Aging; Mitochondria; Proton gradients; Evolution;
   Fermi paradox; Entropy
ID MITOCHONDRIAL DYSFUNCTION; LIFE EXPECTANCY; STRESS-RESPONSE; OBESITY;
   BRAIN; MECHANISMS; SYSTEMS; CONSCIOUSNESS; INFLAMMATION; PHYSIOLOGY
AB Mankind is facing an unprecedented health challenge in the current pandemic of obesity and diabetes. We propose that this is the inevitable (and predictable) consequence of the evolution of intelligence, which itself could be an expression of life being an information system driven by entropy. Because of its ability to make life more adaptable and robust, intelligence evolved as an efficient adaptive response to the stresses arising from an ever-changing environment. These adaptive responses are encapsulated by the epiphenomena of "hormesis", a phenomenon we believe to be central to the evolution of intelligence and essential for the maintenance of optimal physiological function and health. Thus, as intelligence evolved, it would eventually reach a cognitive level with the ability to control its environment through technology and have the ability remove all stressors. In effect, it would act to remove the very hormetic factors that had driven its evolution. Mankind may have reached this point, creating an environmental utopia that has reduced the very stimuli necessary for optimal health and the evolution of intelligence - "the intelligence paradox". One of the hallmarks of this paradox is of course the rising incidence in obesity, diabetes and the metabolic syndrome. This leads to the conclusion that wherever life evolves, here on earth or in another part of the galaxy, the "intelligence paradox" would be the inevitable side-effect of the evolution of intelligence. ET may not need to just "phone home" but may also need to "phone the local gym". This suggests another possible reason to explain Fermi's paradox; Enrico Fermi, the famous physicist, suggested in the 1950s that if extra-terrestrial intelligence was so prevalent, which was a common belief at the time, then where was it? Our suggestion is that if advanced life has got going elsewhere in our galaxy, it can't afford to explore the galaxy because it has to pay its healthcare costs.
C1 [Nunn, Alistair V. W.] Univ Reading, Sch Pharm, Reading RG6 6AP, Berks, England.
   [Guy, Geoffrey W.] GW Pharmaceut, Salisbury SP4 0JQ, Wilts, England.
   [Bell, Jimmy D.] Univ London Imperial Coll Sci Technol & Med, MRC Clin Sci Ctr, Metab & Mol Imaging Grp, Hammersmith Hosp, London W12 0NN, England.
C3 University of Reading; Imperial College London
RP Nunn, AVW (corresponding author), Univ Reading, Sch Pharm, Reading RG6 6AP, Berks, England.
EM a.nunn@reading.ac.uk
RI Nunn, Alistair/ABE-2462-2020
OI Bell, Jimmy/0000-0003-3804-1281
FU MRC [MC_U120061305] Funding Source: UKRI; Medical Research Council
   [MC_U120061305] Funding Source: Medline
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NR 79
TC 13
Z9 13
U1 0
U2 16
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1743-7075
J9 NUTR METAB
JI Nutr. Metab.
PD JUL 29
PY 2014
VL 11
AR 34
DI 10.1186/1743-7075-11-34
PG 13
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA AM2MG
UT WOS:000339684300001
PM 25089149
OA Green Accepted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Sebeková, K
   Krivosíková, Z
   Gajdos, M
AF Sebekova, Katarina
   Krivosikova, Zora
   Gajdos, Martin
TI Total plasma N<SUP>ε</SUP>-(carboxymethyl)lysine and sRAGE levels are
   inversely associated with a number of metabolic syndrome risk factors in
   non-diabetic young-to-middle-aged medication-free subjects
SO CLINICAL CHEMISTRY AND LABORATORY MEDICINE
LA English
DT Article
DE central obesity; healthy subjects; metabolic syndrome;
   N-epsilon-(carboxymethyl)lysine (CML); sRAGE
ID GLYCATION END-PRODUCTS; CIRCULATING SOLUBLE RECEPTOR; SERUM
   CARBOXYMETHYL-LYSINE; CORONARY-ARTERY-DISEASE; C-REACTIVE PROTEIN;
   OXIDATIVE STRESS; INSULIN SENSITIVITY; RAGE; COMPLICATIONS; MARKERS
AB Background: Interaction of advanced glycation end products (AGEs) with their specific cell-surface receptor for AGEs (RAGE) induces production of reactive oxygen species, pro-diabetic, pro-inflammatory, and pro-atherogenic responses. The metabolic syndrome (Metsy) imposes a high risk of development of cardiovascular disease and unequivocally predisposes the non-diabetics to type 2 diabetes mellitus. The aim of the study was to investigate the association between circulating soluble RAGE (sRAGE), N-epsilon-(carboxymethyl) lysine (CML) or AGE-associated fluorescence of plasma (AGE-Fl) with the number of manifested Metsy risk factors in young-to-middle-aged medication-free non-diabetic subjects.
   Methods: Metsy was classified according to NCEP/ATP III criteria; plasma sRAGE and total CML were determined by ELISA methods and AGE-Fl fluorimetrically.
   Results: From among 437 participants aged 33 +/- 11 years, 58% were females. In total 174 subjects were Metsy risk factors-free, 142 presented one, 59 presented two risk factors, and 62 suffered from Metsy. Plasma sRAGE and CML/albumin levels decreased with increasing number of Metsy risk factors (p<0.01, both), while AGE-Fl/albumin levels remained similar. Multivariate analysis selected waist circumference as a main determinant of plasma sRAGE as well as CML/albumin levels.
   Conclusions: In young-to-middle-aged non-diabetic medication-free subjects plasma total CML/albumin and sRAGE levels decrease prior to the manifestation of Metsy. With regards to RAGE-mediated CML trapping into adipose tissue inducing dysregulation of pro-inflammatory cytokines, adipokines, and the development of obesity-related insulin resistance, and the potential involvement of sRAGE in feedback regulation of the toxic effects of AGE/RAGE-mediated signaling, this early decline might be of clinical impact in development of type 2 diabetes and its complications.
C1 [Sebekova, Katarina] Comenius Univ, Fac Med, Inst Mol BioMed, Bratislava 81108, Slovakia.
   [Krivosikova, Zora; Gajdos, Martin] Slovak Med Univ, Fac Med, Dept Clin & Expt Pharmacotherapy, Bratislava, Slovakia.
C3 Comenius University Bratislava; Slovak Medical University Bratislava;
   Comenius University Bratislava
RP Sebeková, K (corresponding author), Comenius Univ, Fac Med, Inst Mol BioMed, Sasinkova 4, Bratislava 81108, Slovakia.
EM kata.sebekova@gmail.com
RI ; Sebekova, Katarina/H-4906-2016
OI Krivosikova, Zora/0000-0002-1271-9923; Sebekova,
   Katarina/0000-0002-9641-9265
FU Slovak Ministry of Health [2005/27-SZU-05]; Slovak Academy of Sciences
   [CoE SAV CENDO II/2/2007]
FX This study was supported by a grant from Slovak Ministry of Health "The
   influence of genetic and environmental factors on early insulin
   resistance prevalence" No. 2005/27-SZU-05 to MG, and partially by a
   grant from Slovak Academy of Sciences CoE SAV CENDO II/2/2007 to KS.
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NR 50
TC 34
Z9 35
U1 0
U2 13
PU WALTER DE GRUYTER GMBH
PI BERLIN
PA GENTHINER STRASSE 13, D-10785 BERLIN, GERMANY
SN 1434-6621
EI 1437-4331
J9 CLIN CHEM LAB MED
JI Clin. Chem. Lab. Med.
PD JAN
PY 2014
VL 52
IS 1
SI SI
BP 139
EP U158
DI 10.1515/cclm-2012-0879
PG 16
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA 275OV
UT WOS:000328687600019
PM 23509221
DA 2025-06-11
ER

PT J
AU Scurt, FG
   Ganz, MJ
   Herzog, C
   Bose, K
   Mertens, PR
   Chatzikyrkou, C
AF Scurt, Florian G.
   Ganz, Maximilian J.
   Herzog, Carolin
   Bose, Katrin
   Mertens, Peter R.
   Chatzikyrkou, Christos
TI Association of metabolic syndrome and chronic kidney disease
SO OBESITY REVIEWS
LA English
DT Review
DE chronic inflammation; chronic kidney diseases; diabetes; hypertension;
   metabolic syndrome; obesity
ID MINERALOCORTICOID RECEPTOR ACTIVATION; FATTY LIVER-DISEASE;
   INSULIN-RESISTANCE; WEIGHT-LOSS; DIABETIC-NEPHROPATHY; OXALATE
   NEPHROPATHY; RENAL-FUNCTION; UNITED-STATES; SLEEP-APNEA; OBESITY
AB The prevalence of kidney disease is increasing rapidly worldwide, reflecting rising rates of obesity, diabetes, and associated metabolic syndrome (MetS). Chronic kidney disease and related comorbidities such as obesity, diabetes, and hypertension place a significant financial burden on healthcare systems. Despite the widespread use of RAAS inhibitors, intensive blood pressure and glycemic control, and newer therapeutic options consisting of sodium/glucose cotransporter-2 (SGLT-2) inhibitors or glucagon-like peptide-1 (GLP-1) receptor agonists, a significant risk of progression to end-stage renal disease remains in the high-risk obese and diabetic population. The MetS is a cluster of cardiovascular risk factors that adversely affect the development and progression of chronic kidney failure. According to the criteria of the World Health Organization, it is defined by visceral adiposity, impaired glucose tolerance or insulin resistance, atherogenic dyslipidemia, raised blood pressure, and microalbuminuria with a albumin-to-creatinine ratio & GE;30 mg/g. At molecular level MetS is marked by a proinflammatory state and increased oxidative stress leading to various pathophysiological changes causing endothelial dysfunction and a hypercoagulable state. Because the kidney is a highly vascularized organ, it is especially susceptible for those microvascular changes. Therefore, the MetS and its individual components are associated with the premature development, acceleration, and progression of chronic kidney disease. Therefore, it is becoming increasingly important to elucidate the underlying mechanisms of MetS-associated chronic kidney disease in order to develop new strategies for preventing and slowing the progression of renal disease. In this review, we will elucidate (i) the renal structural, hemodynamic, and metabolic changes that occur in obesity and obesity-related kidney injury; (ii) the clinicopathological characteristics of obesity-related kidney injury, primarily focusing on obesity-associated glomerulopathy; (iii) the potential additional factors or predisposing factors that may turn patients more susceptible to renal structural or functional compensatory failure and subsequent injury.
C1 [Scurt, Florian G.; Ganz, Maximilian J.; Herzog, Carolin; Mertens, Peter R.] Otto von Guericke Univ, Univ Clin Nephrol & Hypertens Diabetol & Endocrino, Med Fac, Magdeburg, Germany.
   [Bose, Katrin] Univ Hosp Magdeburg, Dept Gastroenterol Hepatol & Infect Dis, Magdeburg, Germany.
   [Chatzikyrkou, Christos] Hannover Med Sch, Dept Nephrol, Hannover, Germany.
   [Scurt, Florian G.] Otto von Guericke Univ, Univ Clin Nephrol Hypertens Diabet & Endocrinol, Leipziger Str 44, D-39120 Magdeburg, Germany.
C3 Otto von Guericke University; University Hospital Magdeburg; Hannover
   Medical School; Otto von Guericke University
RP Scurt, FG (corresponding author), Otto von Guericke Univ, Univ Clin Nephrol Hypertens Diabet & Endocrinol, Leipziger Str 44, D-39120 Magdeburg, Germany.
EM florian.scurt@med.ovgu.de
RI Chatzikyrkou, Christos/AAJ-8934-2020; Scurt, Florian/HPF-6951-2023
OI Scurt, Florian/0000-0001-6197-4720
FU Open Access funding enabled and organized by Projekt DEAL.
FX Open Access funding enabled and organized by Projekt DEAL.
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NR 160
TC 38
Z9 41
U1 3
U2 11
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1467-7881
EI 1467-789X
J9 OBES REV
JI Obes. Rev.
PD JAN
PY 2024
VL 25
IS 1
DI 10.1111/obr.13649
EA OCT 2023
PG 16
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA CT3Z8
UT WOS:001073290100001
PM 37783465
OA hybrid
DA 2025-06-11
ER

PT J
AU Okpala, IC
   Akinboro, AO
   Ezejoifor, IO
   Onunu, AN
   Okwara, BU
AF Okpala, Ifeanyi Chibuzor
   Akinboro, Adeolu Oladayo
   Ezejoifor, Ifeanyi Ogochukwu
   Onunu, Abel N.
   Okwara, Benson Uchechukwu
TI Metabolic Syndrome and Dyslipidemia among Nigerians with Lichen Planus:
   A Cross-Sectional Study
SO INDIAN JOURNAL OF DERMATOLOGY
LA English
DT Article
DE Dyslipidemia; lichen planus; metabolic syndrome; Nigeria
ID CARDIOVASCULAR RISK-FACTORS; INFLAMMATION; CHOLESTEROL; PREVALENCE;
   THICKNESS
AB Background: Lichen planus (LP) is an inflammatory skin disease of unknown etiology associated with chronic inflammation, oxidative stress induction, and cardiovascular risk factors. Objectives: To document the prevalence of metabolic syndrome (MetS), dyslipidemia, and associated factors in Nigerian patients with LP. Methods: A cross-sectional design was made to evaluate 90 patients with LP and 90 controls for MetS and dyslipidemia in two Nigerian teaching hospitals. Diagnosis of LP was made with the aid of histology, and MetS and dyslipidemia were diagnosed using the National Cholesterol Education Program Adult Treatment Panel III criteria. Results: The prevalence of MetS was insignificantly higher in LP than in control (18.9% vs. 13.5, P = 0.311), and dyslipidemia was significantly associated with LP (60% vs. 40%, P = 0.007). LP was associated with higher mean of serum triglyceride (1.21 +/- 0.34 vs. 1.08 +/- 0.32 mmol/L, P = 0.003), low-density lipoprotein cholesterol (3.47 +/- 0.89 vs. 3.12 +/- 0.77 mmol/L, P = 0.007), and T-cholesterol (5.32 +/- 0.88 vs. 4.92 +/- 0.86, P = 0.002). LP patients with MetS were older (P < 0.001) and less likely to have Wickham's striae (P = 0.028) compared to those without MetS. Female LP patients were older (P = 0.047), obese (P = 0.043), and had insignificant increase in MetS prevalence compared to the males. Hypertrophic LP was more frequent in patients with dyslipidemia (63.0% vs. 27.8%, P = 0.002), and the family history of diabetes mellitus (DM) was an independent predictor of MetS in LP patients (odds ratio: 4.4, confidence interval: 1.0-19.1, P = 0.047). Limitation: Availability of fund is a significant factor that limited the sample size to the minimum required as always in a poor-resource setting. Conclusions: LP has an insignificant association with MetS and a significant association with dyslipidemia among Nigerians. The family history of DM is an independent predictor of MetS in LP patients. LP patients should be routinely screened for MetS and its components.
C1 [Okpala, Ifeanyi Chibuzor; Ezejoifor, Ifeanyi Ogochukwu] Nnamdi Azikiwe Univ Awka, Dept Med, Dermatol Unit, Nnewi, Anambra State, Nigeria.
   [Okpala, Ifeanyi Chibuzor; Ezejoifor, Ifeanyi Ogochukwu] Nnamdi Azikiwe Univ, Teaching Hosp, Nnewi, Anambra State, Nigeria.
   [Akinboro, Adeolu Oladayo] Ladoke Akintola Univ Technol, Dept Internal Med, Dermatol Unit, Ogbomosho, Oyo State, Nigeria.
   [Akinboro, Adeolu Oladayo] LAUTECH Teaching Hosp, Ogbomosho, Oyo State, Nigeria.
   [Onunu, Abel N.; Okwara, Benson Uchechukwu] Univ Benin, Dermatol Unit, Dept Med, Benin, Edo State, Nigeria.
   [Onunu, Abel N.; Okwara, Benson Uchechukwu] Univ Benin, Teaching Hosp, Benin, Edo State, Nigeria.
C3 University of Benin; University of Benin
RP Akinboro, AO (corresponding author), Ladoke Akintola Univ Technol, Dept Internal Med, Dermatol Unit, Ogbomosho, Oyo State, Nigeria.; Akinboro, AO (corresponding author), LAUTECH Teaching Hosp, Ogbomosho, Oyo State, Nigeria.
EM deolusteve111@yahoo.com
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NR 30
TC 10
Z9 11
U1 0
U2 4
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, 400059, INDIA
SN 0019-5154
EI 1998-3611
J9 INDIAN J DERMATOL
JI Indian J. Dermatol.
PD JUL-AUG
PY 2019
VL 64
IS 4
BP 303
EP 310
DI 10.4103/ijd.IJD_111_18
PG 8
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA IH8HN
UT WOS:000474746200009
PM 31516140
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Devlin, RB
   Smith, CB
   Schmitt, MT
   Rappold, AG
   Hinderliter, A
   Graff, D
   Carraway, MS
AF Devlin, Robert B.
   Smith, Candice B.
   Schmitt, Michael T.
   Rappold, Ana G.
   Hinderliter, Alan
   Graff, Don
   Carraway, Martha Sue
TI Controlled Exposure of Humans with Metabolic Syndrome to Concentrated
   Ultrafine Ambient Particulate Matter Causes Cardiovascular Effects
SO TOXICOLOGICAL SCIENCES
LA English
DT Article
DE particulate matter; Human; Clinical study; Heart rate variability
ID HEART-RATE-VARIABILITY; AIR-POLLUTION; DIESEL EXHAUST; ENDOTHELIAL
   DYSFUNCTION; BLOOD-PRESSURE; OXIDATIVE STRESS; ELDERLY SUBJECTS;
   PARTICLES; HEALTHY; INHALATION
AB Many studies have reported associations between air pollution particles with an aerodynamic diameter < 2.5 mu m (fine particulate matter (PM)) and adverse cardiovascular effects. However, there is an increased concern that so-called ultrafine PM which comprises the smallest fraction of fine PM (aerodynamic diameter < 0.1 mu m) may be disproportionately toxic relative to the 0.1-2.5 mu m fraction. Ultrafine PM is not routinely measured in state monitoring networks and is not homogenously dispersed throughout an airshed but rather located in hot spots such as near combustion sources (e.g., roads), making it difficult for epidemiology studies to associate exposure to ultrafine PM with adverse health effects. Thirty four middle-aged individuals with metabolic syndrome were exposed for 2 h while at rest in a randomized crossover design to clean air and concentrated ambient ultrafine particles (UCAPS) for 2 h. To further define potential risk, study individuals carrying the null allele for GSTM1 (a prominent antioxidant gene) were identified by genotyping. Blood was obtained immediately prior to exposure, and at 1 and 20 h afterward. Continuous Holter monitoring began immediately prior to exposure and continued for 24 h. Based on changes we observed in previous CAPS studies, we hypothesized that ultrafine CAPS would cause changes in markers of blood inflammation and fibrinolysis as well as changes in heart rate variability and cardiac repolarization. GSTM1 null individuals had altered cardiac repolarization as seen by a change in QRS complexity following exposure to UCAPS and both the entire study population as well as GSTM1 null individuals had increased QT duration. Blood plasminogen and thrombomodulin were decreased in the whole population following UCAPS exposure, whereas C-reactive protein (CRP) and SAA were increased. This controlled human exposure study is the first to show that ambient ultrafine particles can cause cardiovascular changes in people with metabolic syndrome, which affects nearly a quarter of the U.S. adult population.
C1 [Devlin, Robert B.; Smith, Candice B.; Schmitt, Michael T.; Rappold, Ana G.; Graff, Don; Carraway, Martha Sue] US EPA, Natl Hlth & Environm Effects Res Lab, Environm Publ Hlth Div, Res Triangle Pk, NC 27711 USA.
   [Hinderliter, Alan] Univ N Carolina, Sch Med, Chapel Hill, NC 27599 USA.
C3 United States Environmental Protection Agency; University of North
   Carolina School of Medicine; University of North Carolina; University of
   North Carolina Chapel Hill
RP Devlin, RB (corresponding author), US EPA, Natl Hlth & Environm Effects Res Lab, MD 58D, Res Triangle Pk, NC 27711 USA.
EM devlin.robert@epa.gov
RI Smith, Candice/JQV-3201-2023
OI Rappold, Ana/0000-0002-7696-0900
FU Environmental Protection Agency (EPA)
FX Environmental Protection Agency (EPA) (to the authors, who are EPA
   employees).
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NR 58
TC 71
Z9 77
U1 0
U2 31
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1096-6080
EI 1096-0929
J9 TOXICOL SCI
JI Toxicol. Sci.
PD JUL
PY 2014
VL 140
IS 1
BP 61
EP 72
DI 10.1093/toxsci/kfu063
PG 12
WC Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Toxicology
GA AM3AB
UT WOS:000339722100007
PM 24718702
OA hybrid
DA 2025-06-11
ER

PT J
AU Alihanoglu, YI
   Kilic, ID
   Evrengul, H
   Yildiz, BS
   Alur, I
   Uludag, B
   Kuru, O
   Taskoylu, O
   Kaftan, HA
AF Alihanoglu, Yusuf I.
   Kilic, I. Dogu
   Evrengul, Harun
   Yildiz, Bekir S.
   Alur, Ihsan
   Uludag, Burcu
   Kuru, Omur
   Taskoylu, Ozgur
   Kaftan, Havane Asuman
TI The association between coronary flow rate and impaired heart rate
   recovery in patients with metabolic syndrome: A preliminary report
SO CARDIOLOGY JOURNAL
LA English
DT Article
DE metabolic syndrome; heart rate recovery; coronary flow rate; TIMI frame
   count
ID CARDIOVASCULAR-DISEASE MORTALITY; FASTING PLASMA-GLUCOSE; TIMI FRAME
   COUNT; MYOCARDIAL-INFARCTION; INSULIN-RESISTANCE; ENDOTHELIAL
   DYSFUNCTION; NERVOUS-SYSTEM; BLOOD-FLOW; EXERCISE; OBESITY
AB Background: The aim of this study is to evaluate heart rate recovery (HRR) and association between coronary flow rate and HRR in patients with metabolic syndrome (MS) who had morphologically normal coronary angiogram.
   Methods: Study population included 43 patients with MS and 37 control subjects without MS. All patients were selected from individuals who had recently undergone coronary angiography in our hospital and were diagnosed as having angiographically normal coronary arteries. Exercise stress test results obtained prior to coronary angiography were evaluated for calculating HRR and other parameters. In addition, coronary flow was objectively evaluated for each major coronary artery in each subject using TIMI frame count method.
   Results: All HRR values calculated were detected significantly lower in MS group compared to controls (HRR first: 32 +/- 9 vs. 37 +/- 10; p = 0.01, second: 46 +/- 11 vs. 52 +/- 11; p = 0.03, third: 51 +/- 12 vs. 59 +/- 12; p = 0.00, fourth: 54 +/- 13 vs. 61 +/- 2; p = 0.02). TIMI frame counts for each major epicardial coronary artery and mean TIMI frame count were also found to be significantly higher in MS group compared to controls (left anterior descending artery: 51 +/- 24 vs. 39 +/- 15; p = 0.009, left circumflex artery: 32 +/- 11 vs. 24 +/- 7; p = 0.001, right coronary artery: 33 +/- 14 vs. 24 +/- 10; p = 0.003, mean TIMI frame count: 38 +/- 15 vs. 29 +/- 9; p = 0.002). Additionally, significant negative correlations were also detected between HRR first minute and coronary TIMI frame count values in patients with MS. None of MS parameters did not affect HRR values, however mean TIMI frame count independently associated with HRR first minute (p = 0.04) in patients with MS.
   Conclusions: Impaired coronary blood flow occurring in MS might be a clue of autonomic dysfunction in addition to previously known endothelial dysfunction.
C1 [Alihanoglu, Yusuf I.; Kilic, I. Dogu; Evrengul, Harun; Yildiz, Bekir S.; Uludag, Burcu; Kaftan, Havane Asuman] Pamukkale Univ, Sch Med, Dept Cardiol, Denizli, Turkey.
   [Alur, Ihsan] Pamukkale Univ, Sch Med, Dept Cardiovasc Surg, Denizli, Turkey.
   [Kuru, Omur] Erpa Private Hosp, Dept Cardiol, Denizli, Turkey.
   [Taskoylu, Ozgur] Servergazi State Hosp, Dept Cardiol, Denizli, Turkey.
C3 Pamukkale University; Pamukkale University; Servergazi State Hospital
RP Alihanoglu, YI (corresponding author), Pamukkale Univ, Fac Med, Dept Cardiol, Denizli, Turkey.
EM aliizyu@mynet.com
RI Uludağ, Burcu/HTT-2787-2023; YILDIZ, Bekir serhat/HPF-3823-2023
OI ULUDAG, Burcu/0000-0003-2178-6308
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NR 31
TC 0
Z9 1
U1 0
U2 1
PU VIA MEDICA
PI GDANSK
PA UL SWIETOKRZYSKA 73, 80-180 GDANSK, POLAND
SN 1897-5593
EI 1898-018X
J9 CARDIOL J
JI Cardiol. J.
PY 2014
VL 21
IS 3
BP 257
EP 264
DI 10.5603/CJ.a2013.0119
PG 8
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA AR8XB
UT WOS:000343853600007
PM 23990190
OA gold
DA 2025-06-11
ER

PT J
AU Choi, MK
   Bae, YJ
AF Choi, Mi-Kyeong
   Bae, Yun-Jung
TI Relationship between Dietary Magnesium, Manganese, and Copper and
   Metabolic Syndrome Risk in Korean Adults: The Korea National Health and
   Nutrition Examination Survey (2007-2008)
SO BIOLOGICAL TRACE ELEMENT RESEARCH
LA English
DT Article
DE Dietary intake; Magnesium; Manganese Copper; Metabolic syndrome; Korean
   adults
ID REPORTED ENERGY-INTAKE; C-REACTIVE PROTEIN; OXIDATIVE STRESS; SERUM
   COPPER; PREVALENCE; SUPPLEMENTATION; DEFINITION; DIAGNOSIS; VALIDITY
AB Recent studies have reported correlations between mineral intake and metabolic syndrome (MS), but accurate relationships and consistency in the results are difficult to confirm. Accordingly, this study aims to assess the dietary intakes of magnesium (Mg), manganese (Mn), and copper (Cu) to determine their relationship with MS. Data from a total of 5,136 adults (2,084 men, 3,052 women) was collected from the 2007-2008 Korea National Health and Nutrition Examination Survey (KNHANES), and the intakes of Mg, Mn, and Cu of the MS patients were compared with those of healthy adults. The relationship between the intakes of these minerals and the MS risks was analyzed. Diagnosis of MS was evaluated by the National Cholesterol Education Program's Adult Treatment Panel III (NCEP-ATP III) standards. Among all study subjects, 25.9 % (540 subjects) of the men and 24.5 % (748 subjects) of the women met diagnostic criteria for inclusion in the MS group. In the men, daily intakes of Mg and Cu in the MS group were significantly lower than those in control group, and in the women, daily intakes of energy, Mg, Mn, and Cu in the MS group were significantly lower than those of the control group. The women subjects with high blood pressure showed significantly lower intakes of Mg, Mn, and Cu than control subjects. In addition, in the women, the highest quartile of Mg and Cu was inversely associated with MS, but with adjustment were not maintained. However, in the postmenopausal women, MS was significant and inversely associated with the highest quartiles of Cu intake and the association remained significant after adjustments. Considering that MS incidence increases and dietary intake and nutrient density decrease with increasing age, and mineral intake is reduced accordingly, these results suggest that meal management with adequate mineral intake is advisable to control MS.
C1 [Choi, Mi-Kyeong] Kongju Natl Univ, Div Food Sci, Yesan 340702, South Korea.
   [Bae, Yun-Jung] Hanbuk Univ, Dept Food & Nutr Sci, Dongducheon Si 483777, Gyeonggi Do, South Korea.
C3 Kongju National University
RP Bae, YJ (corresponding author), Hanbuk Univ, Dept Food & Nutr Sci, 233-1 Sangpae Dong, Dongducheon Si 483777, Gyeonggi Do, South Korea.
EM byj@hanbuk.ac.kr
RI , 배윤정/J-8327-2019
OI BAE, YUN JUNG/0000-0003-1185-3095
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NR 49
TC 51
Z9 56
U1 0
U2 12
PU HUMANA PRESS INC
PI TOTOWA
PA 999 RIVERVIEW DRIVE SUITE 208, TOTOWA, NJ 07512 USA
SN 0163-4984
EI 1559-0720
J9 BIOL TRACE ELEM RES
JI Biol. Trace Elem. Res.
PD DEC
PY 2013
VL 156
IS 1-3
BP 56
EP 66
DI 10.1007/s12011-013-9852-z
PG 11
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 264RJ
UT WOS:000327897800009
PM 24218228
DA 2025-06-11
ER

PT J
AU Chomsy, IN
   Rohman, MS
   Khotimah, H
   Widodo, N
   Nugrahini, NIP
AF Chomsy, Indah Nur
   Rohman, Mohammad Saifur
   Khotimah, Husnul
   Widodo, Nashi
   Nugrahini, Nur Ida Panca
TI Decaffeinated green tea and green coffee extracts as metformin's add-on
   enhance metabolic syndrome risk factors and improve the cardiac
   insulin-gene-related pathway
SO JOURNAL OF PHARMACY & PHARMACOGNOSY RESEARCH
LA English
DT Article
DE green tea; green coffee; insulin signalling; metabolic syndrome;
   metformin
ID ACTIVATED PROTEIN-KINASE; FATTY-ACID SYNTHASE; NF-KAPPA-B;
   EPIGALLOCATECHIN GALLATE; CAMELLIA-SINENSIS; OXIDATIVE STRESS;
   LIPID-METABOLISM; CHLOROGENIC ACID; RESISTANCE; OBESITY
AB Context: Dysregulation of glucose metabolism in metabolic syndrome (METS) is allegedly due to the disruption of insulin as the main pathway in cellular metabolism. Green tea and green coffee are known to have potential benefit in METS therapy.Aims: To evaluate the effect of therapy using decaffeinated green tea-green coffee extract as metformin's add-on in the risk factors of METS and its effect on the cardiac insulin-gene-related pathway, such as IRS1, PI3Kr1, and GLUT4.Methods: METS model rats were divided into five groups. The rats' level of body weight (BW), fasting blood glucose (FBG), triglycerides (TG), high-density lipoprotein (HDL), insulin (INS), and homeostatic model assessment for insulin resistance (HOMA-IR) were measured periodically. After nine weeks of treatment, the rats were euthanized, and the heart was isolated for measurement of IRS1, PI3Kr1, and GLUT4 gene expression by reverse-transcriptase polymerase chain reaction. Results: This study found that there was a decrease in BW, FBG, TG and an increase in HDL in METS model rats given therapy with metformin and green tea -green coffee extract (COMB) (p<0.0001). There is also improvement in insulin resistance by reducing HOMA-IR in the COMB group (p = 0.0434 for INS and p<0.0001 for HOMA-IR). This study found that IRS1, PI3K, and GLUT4 gene expression increased in the COMB group. The five groups differ significantly, with a p = 0.000.Conclusions: Therapy using a combination of decaffeinated green tea and green coffee extract as an add-on of metformin improved METS risk factor via a significant reduction in BW, FBG, TG, increasing HDL and improving insulin resistance. It also increased the IRS1, PI3Kr1, and GLUT4 gene expression as markers of cardiac insulin-gene-related pathways.
C1 [Chomsy, Indah Nur] Univ Brawijaya, Fac Med, Doctoral Program Med Sci, Malang 65145, Indonesia.
   [Rohman, Mohammad Saifur] Univ Brawijaya, Saiful Anwar Gen Hosp, Fac Med, Dept Cardiol & Vasc Med, Malang 65145, Indonesia.
   [Khotimah, Husnul] Univ Brawijaya, Fac Med, Lab Pharmacol, Malang 65145, Indonesia.
   [Widodo, Nashi] Univ Brawijaya, Fac Math & Nat Sci, Biol Dept, Malang 65145, East Java, Indonesia.
   [Nugrahini, Nur Ida Panca] Univ Brawijaya, Fac Agr Technol, Dept Food Sci & Biotechnol, Doctoral Program Food Sci, Malang 65145, Indonesia.
C3 Brawijaya University; Brawijaya University; Brawijaya University;
   Brawijaya University; Brawijaya University
RP Chomsy, IN (corresponding author), Univ Brawijaya, Fac Med, Doctoral Program Med Sci, Malang 65145, Indonesia.
EM ippoenk@ub.ac.id
RI Nur Chomsy, Indah/HKW-0855-2023; WIDODO, WIDODO/JGL-6847-2023; khotimah,
   husnul/AGJ-3590-2022; Rohman, Mohammad Saifur/JGM-7412-2023
OI , Widodo/0000-0002-1126-498X; Chomsy, Indah Nur/0000-0002-1050-3571;
   khotimah, husnul/0000-0002-2374-4358; Saifur Rohman,
   Mohammad/0000-0001-6461-2223
FU Ministry of Education and Culture, the Republic of Indonesia
   [612.8/UN10.C10/TU/2022]
FX The author would like to thank the Ministry of Education and Culture,
   the Republic of Indonesia, through the PMDSU batch V Scholarship for
   their support (612.8/UN10.C10/TU/2022) , also to all participants who
   contributed to this research, especially to Mifetika Lukitasari, Dwi Adi
   Nugroho, Binti Khoiriyah, and Ilma A. Hurun'in who helped the author a
   lot during the research.
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NR 86
TC 1
Z9 1
U1 0
U2 1
PU JOURNAL PHARMACY & PHARMACOGNOSY RESEARCH-JPPRES
PI ANTOFAGASTA
PA ANGAMOS 0610, ANTOFAGASTA, 00000, CHILE
SN 0719-4250
J9 J PHARM PHARMACOGN R
JI J. Pharm. Pharmacogn. Res.
PD MAY-JUN
PY 2023
VL 11
IS 3
BP 414
EP 425
DI 10.56499/jppres23.1593_11.3.414
PG 12
WC Pharmacology & Pharmacy
WE Emerging Sources Citation Index (ESCI)
SC Pharmacology & Pharmacy
GA M7YO8
UT WOS:001032337700015
DA 2025-06-11
ER

PT J
AU Khodarahmi, M
   Siri, G
   Erahimzadeh, F
   Farhangi, MA
   Shanehbandi, D
AF Khodarahmi, Mahdieh
   Siri, Goli
   Erahimzadeh, Farnoosh
   Farhangi, Mahdieh Abbasalizad
   Shanehbandi, Dariush
TI Dietary glycemic index and glycemic load mediate the effect of CARTPT
   rs2239670 gene polymorphism on metabolic syndrome and metabolic risk
   factors among adults with obesity
SO BMC ENDOCRINE DISORDERS
LA English
DT Article
DE Glycemic index; Glycemic load; Obesity; Structural equation modeling;
   Metabolic syndrome
ID AMPHETAMINE-REGULATED-TRANSCRIPT; INSULIN SENSITIVITY; RELATIVE
   VALIDITY; BLOOD-LIPIDS; DISEASE RISK; ASSOCIATION; METAANALYSIS; STRESS;
   HEALTH; REPRODUCIBILITY
AB Introduction The importance of genetic and dietary factors in occurrence and progression of chronic diseases such as metabolic syndrome (MetS) has been established. However, complex interrelationships, including direct and indirect effects of these variables are yet to be clarified. So, our aim was to investigate the mediating role of glycemic indices in the relationship between CARTPT rs2239670 polymorphism, socio-demographic and psychological factors and metabolic risk factors and the presence of MetS in adults with obesity. Methods In a cross-sectional study of 288 apparently healthy adults with obesity aged 20-50 years, dietary glycemic index (GI) and glycemic load (GL) were measured using a validated semi-quantitative food frequency questionnaire (FFQ). Biochemical parameters, blood pressure and anthropometric indicators were assayed by standard methods. Genotyping was carried out by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique. Structural equation modeling (SEM) was used in the statistical analysis. Results CARTPT rs2239670 had a positive direct effect on MetS (B = 0.037 +/- 0.022; P = 0.043) and, on the other hand, this variant was found to be indirectly associated with MetS presence through mediation of GI (B = 0.039 +/- 0.017; P = 0.009). CARTPT was a significant predictor of both dietary GI and GL (B = 1.647 +/- 0.080 and B = 3.339 +/- 0.242, respectively). Additionally, glycemic indicators appeared to mediate the association of age and gender with LDL-C (B = 0.917 +/- 0.332; P = 0.006) and HDL (B = 1.047 +/- 0.484; P = 0.031), respectively. GI showed a positive relationship with LDL-C (P = 0.024) in men and similar relationships were found between GL and LDL-C (P = 0.050) and cholesterol (P = 0.022) levels in women. Conclusion The SEM findings suggest a hypothesis of the mediating effect of glycemic indices in the relationship between genetic susceptibility to obesity and MetS presence. Our findings need to be confirmed with large prospective studies.
C1 [Khodarahmi, Mahdieh] Isfahan Univ Med Sci, Nutr & Food Secur Res Ctr, Esfahan, Iran.
   [Siri, Goli] Univ Tehran Med Sci, Amir Alam Hosp, Dept Internal Med, Tehran, Iran.
   [Erahimzadeh, Farnoosh] Mashhad Univ Med Sci, Fac Med, Dept Internal Med, Mashhad, Razavi Khorasan, Iran.
   [Farhangi, Mahdieh Abbasalizad] Tabriz Univ Med Sci, Tabriz Hlth Serv Management Res Ctr, Tabriz, Iran.
   [Shanehbandi, Dariush] Tabriz Univ Med Sci, Mol Med Res Ctr, Tabriz, Iran.
C3 Isfahan University of Medical Sciences; Tehran University of Medical
   Sciences; Amir Alam Hospital; Mashhad University of Medical Sciences;
   Tabriz University of Medical Science; Tabriz University of Medical
   Science
RP Farhangi, MA (corresponding author), Tabriz Univ Med Sci, Tabriz Hlth Serv Management Res Ctr, Tabriz, Iran.
EM abbasalizad_m@yahoo.com
RI Farhangi, Mahdieh/AAC-6758-2019; Shanehbandi, Dariush/H-2502-2013;
   khodarahmi, mahdieh/AAJ-9853-2020
OI Siri, Goli/0009-0008-0271-0416
FU Tabriz University of Medical Sciences [IR.TBZMED.REC.1398.460,
   IR.TBZMED.REC.1396.768]
FX The current work has been financially supported by a grant from Tabriz
   University of Medical Sciences (registration code:
   IR.TBZMED.REC.1398.460 and IR.TBZMED.REC.1396.768).
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NR 84
TC 0
Z9 0
U1 1
U2 4
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1472-6823
J9 BMC ENDOCR DISORD
JI BMC Endocr. Disord.
PD NOV 21
PY 2022
VL 22
IS 1
AR 288
DI 10.1186/s12902-022-01188-z
PG 15
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 6I0RY
UT WOS:000885836500001
PM 36404325
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Marudo, CP
   Mohan, V
   Dutta, S
   Reynolds, JM
   Khan, A
   Taldone, SN
   Fu, ES
AF Marudo, Catherine P.
   Mohan, Vikasni
   Dutta, Sanjukta
   Reynolds, John M.
   Khan, Aisha
   Taldone, Sabrina N.
   Fu, Eugene S.
TI Perioperative Risks and Outcomes in Asian American Patients with Type 2
   Diabetes Mellitus and/or Metabolic Syndrome: a Systematic Scoping Review
SO JOURNAL OF RACIAL AND ETHNIC HEALTH DISPARITIES
LA English
DT Review; Early Access
DE Type 2 diabetes mellitus; Metabolic syndrome; Asian American
ID PREVALENCE; ADULTS; DISPARITIES; HYPERGLYCEMIA; ASSOCIATION; MORTALITY;
   SURGERY; SOCIETY; IMPACT
AB Asian Americans (AA) have an increased risk of developing type 2 diabetes mellitus (T2DM) and metabolic syndrome (MetS) compared to non-Hispanic White Americans, yet over half of AA patients with T2DM are underdiagnosed or untreated. Surgical stress, known to exacerbate hyperglycemia in T2DM, is also associated with increased morbidity and mortality. Thus, AA patients may be at elevated risk of experiencing poor outcomes following surgery. This review aims to summarize the available literature on the perioperative (defined as before, during, and after surgery) risk and outcomes of T2DM in AA surgical patients and identify specific knowledge gaps. A scoping review protocol was developed in accordance with PRISMA guidelines. Medline, Embase, Web of Science, Scopus, and Cochrane CENTRAL were comprehensively searched for publications without language or date limits on perioperative management of undiagnosed and diagnosed T2DM and/or MetS in AA. Inclusion criteria included full-text studies conducted in the United States (U.S.), specified AA with T2DM and/or MetS as a study population, and focused on perioperative considerations or clinical outcomes. Search results yielded 862 articles imported into Covidence for title, abstracts, full-text screening, and data extraction. Fifteen publications were identified for full review: 13 (86.6%) retrospective cohort study articles, 1 (6.6%) review article, and 1 (6.6%) randomized controlled trial. These articles represented 2,494,987 total patients and 38,440 aggregate Asian American patients (1.5%). Notable findings amongst studies included (1) higher T2DM rates among AA compared to other racial/ethnic groups, (2) diagnosis variations among AA ethnic subgroups, (3) and conflicting findings on postoperative complications in AA. This review highlights knowledge gaps in our current understanding of disparities regarding perioperative risks and outcomes of AA surgical patients with T2DM and/or MetS. There is a need for stronger research methodologies to guide evidence-based recommendations regarding the perioperative risks and optimal management of this patient population.
C1 [Marudo, Catherine P.; Mohan, Vikasni; Dutta, Sanjukta] Univ Miami, Miller Sch Med, Miami, FL USA.
   [Reynolds, John M.] Univ Miami, Louis Calder Mem Lib, Miller Sch Med, Miami, FL USA.
   [Khan, Aisha; Fu, Eugene S.] Univ Miami, Dept Anesthesiol, Miller Sch Med, 1400 NW 12th Ave Suite 4022, Miami, FL 33136 USA.
   [Taldone, Sabrina N.] Univ Miami, Miller Sch Med, Dept Internal Med, Miami, FL USA.
C3 University of Miami; University of Miami; University of Miami;
   University of Miami
RP Fu, ES (corresponding author), Univ Miami, Dept Anesthesiol, Miller Sch Med, 1400 NW 12th Ave Suite 4022, Miami, FL 33136 USA.
EM efu@med.miami.edu
RI Reynolds, John/AAG-9177-2019
OI Reynolds, John/0000-0001-6744-3517
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NR 44
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER INT PUBL AG
PI CHAM
PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND
SN 2197-3792
EI 2196-8837
J9 J RACIAL ETHN HEALTH
JI J. Racial Ethn. Health Disparities
PD 2025 MAR 5
PY 2025
DI 10.1007/s40615-025-02344-6
EA MAR 2025
PG 17
WC Public, Environmental & Occupational Health
WE Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA Z2R4Q
UT WOS:001437442700001
PM 40042794
OA hybrid
DA 2025-06-11
ER

PT J
AU Mahmood, A
   Haider, H
   Samad, S
   Kumar, D
   Perwaiz, A
   Mushtaq, R
   Ali, A
   Farooq, MZ
   Farhat, H
AF Mahmood, Aysal
   Haider, Hoorain
   Samad, Saba
   Kumar, Danisha
   Perwaiz, Aimen
   Mushtaq, Rabeea
   Ali, Abraish
   Farooq, Muhammad Zain
   Farhat, Hadi
TI Association of white blood cell parameters with metabolic syndrome: A
   systematic review and meta-analysis of 168,000 patients
SO MEDICINE
LA English
DT Article
DE leukocyte; meta-analysis; metabolic syndrome; neutrophil; white blood
   cell
ID LIPOPROTEIN CHOLESTEROL RATIO; MEAN PLATELET VOLUME; OBSTRUCTIVE
   PULMONARY-DISEASE; TO-LYMPHOCYTE RATIO; HEMATOLOGIC PARAMETERS;
   GLUCOSE-METABOLISM; OXIDATIVE STRESS; COUNT; NEUTROPHIL; POPULATION
AB Background: Leukocyte parameters are predicted to be affected in patients with metabolic syndrome (MetS). We conducted a systematic review and meta-analysis to study the association between white blood cell parameters (WBC) in people with and without MetS. Methods: PubMed, EMBASE, Scopus and Cochrane Library databases were searched according to the study protocol. The standardized mean difference (SMD) and 95% confidence intervals (CI) of leukocyte markers between individuals with and without MetS were pooled using an inverse variance model. Additionally, a subgroup analysis by sex was performed where possible. Methodological quality assessment was conducted using the Newcastle-Ottawa scale (NOS) for observational studies and the Cochrane Risk of Bias tool 2.0 for Randomized Controlled Trials (RCTs). Results: Of 6068 articles identified, 63 were eligible for the study. Compared to controls, individuals with MetS showed significantly higher concentrations of total leukocyte count (SMD [95% CI]: 0.60 [0.55-0.65]; P < .00001; I2 = 100%), neutrophil counts (0.32 [0.28-0.37]; P < .00001; I2 = 99%), lymphocyte counts (0.15 [0.07-0.23]; P = .0004; I2 = 100%), basophil counts (0.01 [0.00-0.02]; P = .02; I2 = 98%), monocyte counts (0.05 [0.02-0.09]; P = .003; I2 = 99%), and neutrophil-to-lymphocyte ratio (0.24 [0.15-0.33]; P < .00001; I2 = 98%). There were no significant differences in the eosinophil count (0.02 [-0.01 to 0.05]; P = .19; I2 = 96%) and monocyte-to-lymphocyte ratio (0.06 [-0.05 to 0.17]; P = .27; I2 = 100%) between patients with and without MetS, however, the lymphocyte-to-monocyte ratio (0.52 [-0.81 to -0.23]; P = .0005; I2 = 52%) tended to be significantly lower in patients with MetS. Conclusion: Biomarkers such as total leukocyte count, neutrophil count, lymphocyte count, basophil count, monocyte count and neutrophil-to-lymphocyte ratio are associated with higher levels in patients in MetS and thus can potentially be used for early detection of MetS.
C1 [Mahmood, Aysal; Haider, Hoorain; Samad, Saba; Kumar, Danisha; Perwaiz, Aimen; Mushtaq, Rabeea; Ali, Abraish] Dow Univ Hlth Sci DUHS, Karachi, Pakistan.
   [Farooq, Muhammad Zain] Univ S Florida, Moffitt Canc Ctr, Tampa, FL USA.
   [Farhat, Hadi] Lebanese Univ, Fac Med, Beirut RGJF 6RW, Lebanon.
C3 State University System of Florida; University of South Florida; H Lee
   Moffitt Cancer Center & Research Institute
RP Farhat, H (corresponding author), Lebanese Univ, Fac Med, Beirut RGJF 6RW, Lebanon.
EM aysalmehmood@gmail.com; hoorainhaider97@gmail.com;
   sabasamad1997@gmail.com; danisha.kumar21@dmc.duhs.edu.pk;
   Aimenp.97@gmail.com; rabeeamushtaq77@gmail.com; abraishali567@gmail.com;
   farooq_zain14@yahoo.com; hadifarhat2001@yahoo.com
RI Farhat, Hadi/JCN-4808-2023
OI Farhat, Hadi/0009-0009-5991-4038; Kumar, Danisha/0000-0001-7735-6468;
   Mahmood, Aysal/0000-0001-9924-8038
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NR 91
TC 4
Z9 4
U1 3
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD MAR 8
PY 2024
VL 103
IS 10
AR e37331
DI 10.1097/MD.0000000000037331
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA QS0C1
UT WOS:001222731500051
PM 38457562
OA gold
DA 2025-06-11
ER

PT J
AU Zhang, C
   Zhang, QH
   Wang, YX
   Liu, R
   Dong, Y
   Shi, ZY
   Sun, Y
   Ge, ZW
   Liang, YJ
   Zhang, JY
   Du, YF
   Qiu, CX
AF Zhang, Cong
   Zhang, Qinghua
   Wang, Yongxiang
   Liu, Rui
   Dong, Yi
   Shi, Zhuoyu
   Sun, Ying
   Ge, Zhengwei
   Liang, Yajun
   Zhang, Jiayi
   Du, Yifeng
   Qiu, Chengxuan
TI Association of Metabolic Syndrome with Macular Thickness and Volume in
   Older Adults: A Population-Based Optical Coherence Tomography Study
SO METABOLIC SYNDROME AND RELATED DISORDERS
LA English
DT Article
DE metabolic syndrome; macular thickness; spectral-domain optical coherence
   tomography; old age; population-based study
ID RETINAL MICROVASCULAR SIGNS; ATHEROSCLEROSIS RISK; OXIDATIVE STRESS;
   LAYER THICKNESS; HEALTHY EYES; SEX-HORMONES; GENDER; NEURODEGENERATION;
   DETERMINANTS; DEFINITION
AB Background: To explore the associations of the metabolic syndrome (MetS) and individual components with macular thickness and volume among rural-dwelling Chinese older adults.Methods: This population-based cross-sectional study included 705 participants (age >= 60 years) derived from the MIND-China study. In 2018-2019, we collected data through face-to-face interview, clinical examination, optical coherence tomography (OCT) examination, and blood test. We measured macular thickness and volume using spectral-domain OCT. MetS was defined following the International Diabetes Federation (IDF) criteria, the IDF/American Heart Association (AHA) criteria, the National Cholesterol Education Program-Adult Treatment Panel III criteria, and the Chinese Diabetes Society (CDS) criteria. Data were analyzed with multivariable general linear models.Results: MetS was significantly associated with thinner macula in central (multivariable-adjusted beta = -5.29; 95% confidence interval: -9.31 to -1.26), parafoveal (-2.85; -5.73 to 0.04) and perifoveal regions (-4.37; -6.79 to -1.95) when using the IDF criteria, in the perifoveal regions (-3.82; -6.18 to -1.47) when using the IDF/AHA criteria, and in the central region (-5.63; -10.25 to -1.02) when using the CDS criteria, and with reduced macular volume when using the IDF (-0.16; -0.26 to -0.07) and IDF/AHA (-0.13; -0.22 to -0.04) criteria. In the parafoveal region, the IDF-defined MetS was significantly associated with thinner retina in men (beta = -6.25; -10.94 to -1.56) but not in women. Abdominal obesity (-2.83; -5.41 to -0.25) and elevated fasting blood glucose (-2.65; -5.08 to -0.21) were associated with thinner macular thickness in the perifoveal region.Conclusion: MetS is associated with macular thinning and reduced macular volume among rural-dwelling older adults, and the associations vary by the defining criteria of MetS.
C1 [Zhang, Cong; Zhang, Qinghua; Wang, Yongxiang; Liu, Rui; Dong, Yi; Shi, Zhuoyu; Du, Yifeng; Qiu, Chengxuan] Shandong Univ, Shandong Prov Hosp, Cheeloo Coll Med, Dept Neurol, 324 Jingwuweiqi Rd, Jinan 250021, Peoples R China.
   [Zhang, Qinghua; Wang, Yongxiang; Sun, Ying; Du, Yifeng] Shandong First Med Univ, Shandong Prov Hosp, Dept Neurol, Jinan, Peoples R China.
   [Ge, Zhengwei] Shandong Univ, Shandong Prov Hosp, Cheeloo Coll Med, Dept Ophthalmol, Jinan, Peoples R China.
   [Liang, Yajun; Qiu, Chengxuan] Stockholm Univ, Karolinska Inst, Aging Res Ctr, Dept Neurobiol Care Sci & Soc, Stockholm, Sweden.
   [Liang, Yajun; Qiu, Chengxuan] Stockholm Univ, Karolinska Inst, Ctr Alzheimer Res, Stockholm, Sweden.
   [Liang, Yajun] Karolinska Inst, Dept Global Publ Hlth, Stockholm, Sweden.
   [Zhang, Jiayi] Fudan Univ, Inst Brain Sci, MOE Frontiers Ctr Brain Sci, State Key Lab Med Neurobiol, Shanghai, Peoples R China.
   [Qiu, Chengxuan] Stockholm Univ, Karolinska Inst, Aging Res Ctr, Dept Neurobiol Care Sci & Soc, Tomtebodavagen 18A, S-17165 Solna, Sweden.
   [Qiu, Chengxuan] Stockholm Univ, Karolinska Inst, Ctr Alzheimer Res, Tomtebodavagen 18A, S-17165 Solna, Sweden.
C3 Shandong First Medical University & Shandong Academy of Medical
   Sciences; Shandong University; Shandong First Medical University &
   Shandong Academy of Medical Sciences; Shandong First Medical University
   & Shandong Academy of Medical Sciences; Shandong University; Stockholm
   University; Karolinska Institutet; Karolinska Institutet; Stockholm
   University; Karolinska Institutet; Fudan University; Karolinska
   Institutet; Stockholm University; Karolinska Institutet; Stockholm
   University
RP Du, YF; Qiu, CX (corresponding author), Shandong Univ, Shandong Prov Hosp, Cheeloo Coll Med, Dept Neurol, 324 Jingwuweiqi Rd, Jinan 250021, Peoples R China.; Qiu, CX (corresponding author), Stockholm Univ, Karolinska Inst, Aging Res Ctr, Dept Neurobiol Care Sci & Soc, Tomtebodavagen 18A, S-17165 Solna, Sweden.; Qiu, CX (corresponding author), Stockholm Univ, Karolinska Inst, Ctr Alzheimer Res, Tomtebodavagen 18A, S-17165 Solna, Sweden.
EM duyifeng2013@163.com; chengxuan.qiu@ki.se
RI Zhang, Jiayi/GQQ-9674-2022; Du, Yifeng/IST-9657-2023; wang,
   yongxiang/AAD-6337-2019; zhang, qinghua/A-1736-2019
OI Qiu, Chengxuan/0000-0003-1922-4912
FU National Key Research and Development Program of China [2017YFC1310100];
   Academic Promotion Program of Shandong First Medical University; Taishan
   Scholar Program of Shandong Province, China; Shandong Province
   postdoctoral innovation research program; Swedish Research Council (VR)
   [2017-05819, 2020-01574]; Swedish Foundation for International
   Co-operation in Research and Higher Education (STINT) [CH2019-8320];
   Karolinska Institutet, Stockholm, Sweden [2018-01854, 2020-01456];
   Formas [2020-01456] Funding Source: Formas; Swedish Research Council
   [2020-01574, 2017-05819] Funding Source: Swedish Research Council
FX This study was supported in part by grants from the National Key
   Research and Development Program of China (Grant No. 2017YFC1310100),
   the Academic Promotion Program of Shandong First Medical University, and
   the Taishan Scholar Program of Shandong Province, China, Shandong
   Province postdoctoral innovation research program. C Qiu received grants
   from the Swedish Research Council (VR, Grant Nos. 2017-05819 and
   2020-01574), the Swedish Foundation for International Co-operation in
   Research and Higher Education (STINT, Grant No. CH2019-8320) for the
   Joint China-Sweden Mobility Program, and Karolinska Institutet (Grant
   Nos. 2018-01854 and 2020-01456), Stockholm, Sweden. The funding agency
   had no role in the study design, data collection and analysis, writing
   of this article, or decision on publishing.
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NR 52
TC 0
Z9 0
U1 1
U2 6
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-4196
EI 1557-8518
J9 METAB SYNDR RELAT D
JI Metab. Syndr. Relat. Disord.
PD MAR 1
PY 2024
VL 22
IS 2
BP 141
EP 150
DI 10.1089/met.2023.0098
EA JAN 2024
PG 10
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA LJ5W4
UT WOS:001154770900001
PM 38237159
DA 2025-06-11
ER

PT J
AU Pakdeechote, P
   Poasakate, A
   Prasatthong, P
   Potue, P
   Khamseekaew, J
   Maneesai, P
AF Pakdeechote, Poungrat
   Poasakate, Anuson
   Prasatthong, Patoomporn
   Potue, Prapassorn
   Khamseekaew, Juthamas
   Maneesai, Putcharawipa
TI Mitigation effect of galangin against aortic dysfunction and hypertrophy
   in rats with metabolic syndrome
SO HELIYON
LA English
DT Article
DE Galangin; Metabolic syndrome; Vascular function
ID RENIN-ANGIOTENSIN SYSTEM; DIET-INDUCED-OBESITY; INSULIN-RESISTANCE;
   ENDOTHELIAL FUNCTION; OXIDATIVE STRESS; NITRIC-OXIDE; ASIATIC ACID;
   MOUSE MODEL; INFLAMMATION; EXPRESSION
AB Vascular alterations induced by a high-fat diet (HFD) are involved in the development of hy-pertension. Galangin, a flavonoid, is the major active compound isolated from galangal and propolis. The objective of this study was to investigate the effect of galangin on aortic endothelial dysfunction and hypertrophy, and the mechanisms involved in HFD-induced metabolic syndrome (MS) in rats. Male Sprague-Dawley rats (220-240 g) were separated into three groups: control + vehicle, MS + vehicle, and MS + galangin (50 mg/kg). Rats with MS received HFD plus 15% fructose solution for 16 weeks. Galangin or vehicle was orally administered daily for the final four weeks. Galangin reduced body weight and mean arterial pressure in HFD rats (p < 0.05). It also reduced circulating fasting blood glucose, insulin, and total cholesterol levels (p < 0.05). Impaired vascular responses to the exogenous acetylcholine observed in the aortic ring of HFD rats were restored by galangin (p < 0.05). However, the response to sodium nitroprusside did not differ between the groups. Galangin enhanced the expression of the aortic endothelial nitric oxide synthase (eNOS) protein and increased circulating nitric oxide (NO) levels in the MS group (p < 0.05). Aortic hypertrophy in HFD rats was alleviated by galangin (p < 0.05). Increases in tumour necrosis factor-alpha (TNF-alpha), interleukin (IL)-6 levels, angiotensin-converting enzyme activity and angiotensin II (Ang II) concentrations in rats with MS were suppressed in galangin treated group (p < 0.05). Furthermore, galangin reduced the upregulation of angiotensin II type I re-ceptor (AT1R) and transforming growth factor-beta (TGF-beta) expression in rats with MS (p < 0.05). In conclusion, galangin alleviates metabolic disorders and improves aortic endothelial dysfunction and hypertrophy in the MS group. These effects were consistent with increased NO availability, reduced inflammation, and suppressing Ang II/AT1R/TGF-beta signalling pathway.
C1 [Pakdeechote, Poungrat; Poasakate, Anuson; Potue, Prapassorn; Khamseekaew, Juthamas; Maneesai, Putcharawipa] Khon Kaen Univ, Fac Med, Dept Physiol, Khon Kaen 40002, Thailand.
   [Prasatthong, Patoomporn] Nakhon Sawan Rajabhat Univ, Fac Sci & Technol, Dept Hlth Sci, Nakhon Sawan 60000, Thailand.
C3 Khon Kaen University; Nakhon Sawan Rajabhat University
RP Maneesai, P (corresponding author), Khon Kaen Univ, Fac Med, Dept Physiol, Khon Kaen 40002, Thailand.
EM ppoung@kku.ac.th; anuson_p@kkumail.com; patoomporn.p@nsru.ac.th;
   prappo@kku.ac.th; juthakh@kku.ac.th; putcma@kku.ac.th
RI Maneesai, Putcharawipa/AAK-4258-2021
OI Maneesai, Putcharawipa/0000-0003-0889-6211
FU Khon Kaen University [65]
FX This study was supported by the Fundamental Research Fund (65), Research
   and Graduate Study, Khon Kaen University, provided funding for this
   study Khon Kaen, Thailand.
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NR 52
TC 4
Z9 4
U1 0
U2 3
PU CELL PRESS
PI CAMBRIDGE
PA 50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA
EI 2405-8440
J9 HELIYON
JI Heliyon
PD MAY
PY 2023
VL 9
IS 5
AR e16500
DI 10.1016/j.heliyon.2023.e16500
EA MAY 2023
PG 11
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA I4PW4
UT WOS:001002626100001
PM 37251824
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Zhang, HD
   Man, QQ
   Song, PK
   Li, SR
   Liu, XB
   Wang, LJ
   Li, YQ
   Hu, YC
   Yang, LC
AF Zhang, Huidi
   Man, Qingqing
   Song, Pengkun
   Li, Siran
   Liu, Xiaobing
   Wang, Lijuan
   Li, Yuqian
   Hu, Yichun
   Yang, Lichen
TI Association of whole blood copper, magnesium and zinc levels with
   metabolic syndrome components in 6-12-year-old rural Chinese children:
   2010-2012 China National Nutrition and Health Survey
SO NUTRITION & METABOLISM
LA English
DT Article
DE MetS components; Whole blood; Copper; Zinc; Magnesium; Chinese children
ID OXIDATIVE STRESS; SERUM; DIETARY; PLASMA; ADULTS; ESSENTIALITY;
   INFLAMMATION; ADOLESCENTS; SELENIUM; GLUCOSE
AB Background Metabolic syndrome (MetS) is significantly associated with the risk of cardiovascular disease and its prevalence is showing a trend of getting younger. Previous studies on the relationship between elements and MetS were mostly reported in adults with single element analysis, while reports in children with combined effects of multiple elements were very limited. The aim of this study is to investigate the association between whole blood Cu, Mg and Zn in both single and combined effects and MetS components in rural Chinese children aged 6-12 years based on the data from 2010-2012 China National Nutrition and Health Survey. Methods A total of 911 children (51.2% male, 48.7% female) aged 6-12 years were included. Basic characteristics and MetS component parameters were collected and determined by trained stuffs. Elements were detected by Inductively Coupled Plasma Mass Spectrometry (ICP-MS). Multivariate logistic regression analysis was performed to examine the independent relationship between elements and MetS components. Results In single metal analysis, copper was positively associated with elevated waist (OR = 2.00, 1.18-3.28) and all of the metals were associated with elevated TG. And the comprehensive analysis of multiple elements were mostly consistent with the results of single element analysis (low Cu + high Zn with elevated TG (OR = 2.21, 1.18-4.13), high Cu + low Mg with elevated TG (OR = 0.40, 0.16-0.95), high Cu + high Mg with elevated waist (OR = 2.03, 1.26-3.27)), except the combination of Zn and Mg (high Zn + low Mg with reduced HDL-C (OR = 0.47, 0.28-0.77)). Conclusions Our study suggested Cu, Zn and Mg in children are indeed associated with metabolic syndrome components, whether in single element or multi-element combined analysis. The results will be confirmed through additional cohort research.
C1 [Zhang, Huidi; Man, Qingqing; Song, Pengkun; Li, Siran; Liu, Xiaobing; Wang, Lijuan; Li, Yuqian; Hu, Yichun; Yang, Lichen] Chinese Ctr Dis Control & Prevent, Natl Inst Nutr & Hlth, Natl Hlth Commiss Peoples Republ China, Key Lab Trace Element Nutr, Beijing, Peoples R China.
C3 Chinese Center for Disease Control & Prevention; National Institute for
   Nutrition & Health, Chinese Center for Disease Control & Prevention
RP Yang, LC (corresponding author), Chinese Ctr Dis Control & Prevent, Natl Inst Nutr & Hlth, Natl Hlth Commiss Peoples Republ China, Key Lab Trace Element Nutr, Beijing, Peoples R China.
EM yanglc@ninh.chinacdc.cn
RI wang, li/HMD-1420-2023; Song, Pengkun/HHM-9517-2022
FU Study of Diet and Nutrition Assessment and Intervention Technology from
   Active Health and Aging Technologic Solutions Major Project of National
   Key R&D Program-Study on the Key Nutrients Requirement of Chinese
   Population [2020YFC2006300, 2020YFC2006302]
FX This study was funded by Study of Diet and Nutrition Assessment and
   Intervention Technology (No. 2020YFC2006300) from Active Health and
   Aging Technologic Solutions Major Project of National Key R&D
   Program-Study on the Key Nutrients Requirement of Chinese Population
   (No. 2020YFC2006302).
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NR 36
TC 12
Z9 13
U1 0
U2 8
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1743-7075
J9 NUTR METAB
JI Nutr. Metab.
PD JUN 27
PY 2021
VL 18
IS 1
AR 67
DI 10.1186/s12986-021-00593-w
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA TE3TO
UT WOS:000669936300002
PM 34176509
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Liu, CW
   Chen, KH
   Tseng, CK
   Chang, WC
   Wu, YW
   Hwang, JJ
AF Liu, C. -W.
   Chen, K. -H.
   Tseng, C. -K.
   Chang, W. -C.
   Wu, Y. -W.
   Hwang, J. -J.
TI The dose-response effects of uric acid on the prevalence of metabolic
   syndrome and electrocardiographic left ventricular hypertrophy in
   healthy individuals
SO NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
LA English
DT Article
DE Uric acid; Metabolic syndrome; Left ventricular hypertrophy;
   Cardiovascular disease; Urate-lowering therapy
ID OXIDATIVE STRESS; MORTALITY; HYPERURICEMIA; ASSOCIATION; PREDICTOR;
   DISEASE; RISK
AB Background and aim: Hyperuricemia (HUA) is associated with the prevalence of metabolic syndrome (MetS) and cardiovascular risks in various populations. HUA is also able to induce cardiomyocyte hypertrophy in mouse models. However, the dose-response effects of serum uric acid (SUA) on the prevalence of MetS and electrocardiographic left ventricular hypertrophy (LVH) are unclear.
   Methods and results: We retrospectively collected data from 18,932 individuals who underwent an annual health examination between 1/1/2016 and 12/31/2016. We excluded those with systemic diseases or missing questionnaires. The primary study endpoints were the prevalence of MetS and LVH, which were defined by the criteria for the Taiwanese population and the "SPRINT" trial. The cohort consisted of 17,913 individuals with a mean age of 31.2 years (SD 7.4) and a mean body mass index of 24.6 kg/m(2) (SD 3.6); 87.1% of the individuals were men. The prevalence rates of HUA, MetS, and LVH were 29.5%, 9.4%, and 0.32%, respectively, in the overall study population. The HUA group was predominantly male and had significantly poorer lifestyle choices and greater laboratory cardiometabolic biomarker values than did the normouricemic group. However, the frequencies of physical activity were comparable between the two groups. After adjusting for confounders, SUA was associated with MetS (OR:1.473, 95% CI:1.408-1.540, P < 0.001) and LVH (OR:1.301, 95% CI:1.064-1.591, P = 0.01).
   Conclusion: We demonstrated that the dose-response effects of SUA are associated with the prevalence of MetS and electrocardiographic LVH in healthy individuals from Taiwan. Based on this evidence, future studies should investigate urate-lowering therapy and cardiovascular benefits in individuals with HUA (C) 2018 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.
C1 [Liu, C. -W.; Tseng, C. -K.; Chang, W. -C.] Tri Serv Gen Hosp, Natl Def Med Ctr, Dept Internal Med, Songshan Branch, Taipei 10581, Taiwan.
   [Liu, C. -W.] Far Eastern Mem Hosp, Cardiol Div, Cardiovasc Med Ctr, New Taipei 22060, Taiwan.
   [Liu, C. -W.; Chen, K. -H.; Wu, Y. -W.; Hwang, J. -J.] Natl Taiwan Univ, Coll Med, Grad Inst Clin Med, Taipei 10051, Taiwan.
   [Chen, K. -H.] Tri Serv Gen Hosp, Dept Clin Pathol, Songshan Branch, Natl Def Med Ctr, Taipei 10581, Taiwan.
   [Wu, Y. -W.; Hwang, J. -J.] Natl Taiwan Univ, Dept Internal Med, Coll Med & Hosp, Taipei 10581, Taiwan.
   [Wu, Y. -W.] Natl Taiwan Univ, Dept Nucl Med, Coll Med & Hosp, Taipei 10581, Taiwan.
   [Wu, Y. -W.] Far Eastern Mem Hosp, Div Cardiovasc, Dept Nucl Med & Cardiol, Med Ctr, New Taipei 22060, Taiwan.
   [Wu, Y. -W.] Natl Yang Ming Univ, Sch Med, Taipei 11221, Taiwan.
   [Hwang, J. -J.] Natl Taiwan Univ Hosp, Yunlin Branch, Dept Internal Med, Taipei 64057, Yunlin, Taiwan.
C3 National Defense Medical Center; Tri-Service General Hospital; Far
   Eastern Memorial Hospital; National Taiwan University; Tri-Service
   General Hospital; National Defense Medical Center; National Taiwan
   University; National Taiwan University; Far Eastern Memorial Hospital;
   National Yang Ming Chiao Tung University; National Taiwan University;
   National Taiwan University Hospital
RP Hwang, JJ (corresponding author), Natl Taiwan Univ Hosp, Dept Internal Med, 1,Sec 4,Roosevelt Rd, Taipei 100, Taiwan.
EM issac700319@icloud.com
RI ; Liu, Cheng-Wei/AAV-2919-2020
OI WU, YEN-WEN/0000-0003-1520-1166; Liu, Cheng-Wei/0000-0001-5095-8039
FU Ministry of National Defense, Republic of China (Taiwan)
   [NMMS-1050009923]; Tri-Service General Hospital Songshan Branch [105-02,
   107-08]; Swedish National Space Agency (SNSA) [107/08] Funding Source:
   Swedish National Space Agency (SNSA)
FX This study was supported by the Ministry of National Defense, Republic
   of China (Taiwan) (grant number NMMS-1050009923) and Tri-Service General
   Hospital Songshan Branch (105-02 and 107-08). The authors designed the
   study, collected the data, performed the statistical analyses, wrote the
   report and decided to submit the article for publication. The funding
   source had no involvement in the study.
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NR 32
TC 29
Z9 32
U1 0
U2 8
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0939-4753
EI 1590-3729
J9 NUTR METAB CARDIOVAS
JI Nutr. Metab. Carbiovasc. Dis.
PD JAN
PY 2019
VL 29
IS 1
BP 30
EP 38
DI 10.1016/j.numecd.2018.10.001
PG 9
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism; Nutrition
   & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism;
   Nutrition & Dietetics
GA HG2NL
UT WOS:000454800000006
PM 30545672
DA 2025-06-11
ER

PT J
AU Su, MC
   Chen, YC
   Huang, KT
   Wang, CC
   Lin, MC
   Lin, HC
AF Su, Mao-Chang
   Chen, Yung-Che
   Huang, Kuo-Tung
   Wang, Chin-Chou
   Lin, Meng-Chih
   Lin, Hsin-Ching
TI Association of metabolic factors with high-sensitivity C-reactive
   protein in patients with sleep-disordered breathing
SO EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
LA English
DT Article
DE Cardiovascular risk; High-sensitivity C-reactive protein; Metabolic
   syndrome; Sleep-disordered breathing
ID POSITIVE AIRWAY PRESSURE; INSULIN-RESISTANCE; OXIDATIVE STRESS; APNEA
   SYNDROME; ATHEROSCLEROSIS; INFLAMMATION; DISEASE; MARKERS; HYPERTENSION;
   DYSFUNCTION
AB Sleep-disordered breathing (SDB) such as snoring or obstructive sleep apnea and metabolic syndrome are both related to cardiovascular diseases. Being a surrogate marker of high risk for cardiovascular disorder, the high-sensitivity C-reactive protein (hs-CRP) level is thought to be elevated in patients with both SDB and metabolic syndrome. To understand better the development of cardiovascular disease in patients with SDB, we examined the association of metabolic variables with hs-CRP levels in adult patients with symptoms of SDB and without any previous treatment, who were selected to participate in the study. Metabolic parameters including fasting blood glucose, lipid profile and hs-CRP were measured following an overnight polysomnography. Laboratory and polysomnographic data were analyzed to identify variables related to high hs-CRP levels. A total of 309 patients with SDB participated in this study. Of these, 139 presented with hs-CRP < 1 mg/L and 52 presented with hs-CRP > 3 mg/L. Patients with high hs-CRP showed a higher apnea-hypopnea index (AHI), body mass index (BMI), fasting glucose, and triglyceride level, and a lower mean and minimal oxygen saturation and HDL-cholesterol level. However, ordinal regression analysis demonstrated that only a higher BMI and fasting glucose level and a lower HDL-cholesterol level were independent risk factors for cardiovascular diseases (OR = 1.076, 95 % CI = 1.009-1.147, p = 0.005; OR = 1.011, 95 % CI = 1.004-1.019, p = 0.008; OR = 0.966, 95 % CI = 0.947-0.984, p < 0.001, respectively). The results showed that elevated hs-CRP is common in patients with SDB but is not independently associated with the severity of SDB. Metabolic factors such as a higher BMI and fasting blood glucose and a lower HDL-cholesterol level were more strongly associated with elevated hs-CRP rather than with SDB severity, suggesting that metabolic parameters are important contributors to cardiovascular diseases and should be corrected in patients with SDB.
C1 [Su, Mao-Chang; Chen, Yung-Che; Huang, Kuo-Tung; Wang, Chin-Chou; Lin, Meng-Chih] Kaohsiung Chang Gung Mem Hosp, Dept Internal Med, Div Pulm & Crit Care Med, Kaohsiung 83305, Taiwan.
   [Su, Mao-Chang; Chen, Yung-Che; Huang, Kuo-Tung; Wang, Chin-Chou; Lin, Meng-Chih; Lin, Hsin-Ching] Chang Gung Univ, Coll Med, Kaohsiung 83305, Taiwan.
   [Su, Mao-Chang; Chen, Yung-Che; Huang, Kuo-Tung; Lin, Meng-Chih; Lin, Hsin-Ching] Kaohsiung Chang Gung Mem Hosp, Sleep Ctr, Kaohsiung 83305, Taiwan.
   [Su, Mao-Chang; Wang, Chin-Chou; Lin, Meng-Chih] Chang Gung Inst Technol, Dept Resp Care, Chiayi, Taiwan.
   [Lin, Hsin-Ching] Kaohsiung Chang Gung Mem Hosp, Dept Otolaryngol, Kaohsiung 83305, Taiwan.
C3 Chang Gung Memorial Hospital; Chang Gung University; Chang Gung Memorial
   Hospital; Chang Gung University of Science & Technology; Chang Gung
   Memorial Hospital
RP Lin, HC (corresponding author), Kaohsiung Chang Gung Mem Hosp, Dept Otolaryngol, 123 Ta Pei Rd, Kaohsiung 83305, Taiwan.
EM enthclin@aol.com
RI Chen, Yung-Che/AAL-5167-2020; Chuang, Chuang Ching Hui/GLU-3454-2022
FU Chang Gung Memorial Hospital [CMRPG870971]
FX This work was supported by the Chang Gung Memorial Hospital (grant
   number: CMRPG870971). The authors would like to thank Richard H. Davis,
   English teacher, M.A., for professional editing.
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NR 28
TC 7
Z9 8
U1 0
U2 6
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0937-4477
J9 EUR ARCH OTO-RHINO-L
JI Eur. Arch. Oto-Rhino-Laryn.
PD FEB
PY 2013
VL 270
IS 2
BP 749
EP 754
DI 10.1007/s00405-012-2191-4
PG 6
WC Otorhinolaryngology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Otorhinolaryngology
GA 081DD
UT WOS:000314295800048
PM 23053373
DA 2025-06-11
ER

PT J
AU Osei, F
   Block, A
   Wippert, PM
AF Osei, Francis
   Block, Andrea
   Wippert, Pia-Maria
TI Association of primary allostatic load mediators and metabolic syndrome
   (MetS): A systematic review
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Review
DE allostatic load; cortisol; dehydroepiandrosterone sulfate; epinephrine;
   norepinephrine; metabolic syndrome; primary marker
ID PITUITARY-ADRENAL AXIS; DEHYDROEPIANDROSTERONE-SULFATE; CORTISOL-LEVELS;
   INSULIN-RESISTANCE; MASS-SPECTROMETRY; BASAL CORTISOL; STRESS; DHEA;
   HEALTH; SERUM
AB Allostatic load (AL) exposure may cause detrimental effects on the neuroendocrine system, leading to metabolic syndrome (MetS). The primary mediators of AL involve serum dehydroepiandrosterone sulfate (DHEAS; a functional HPA axis antagonist); further, cortisol, urinary norepinephrine (NE), and epinephrine (EPI) excretion levels (assessed within 12-h urine as a golden standard for the evaluation of the HPA axis activity and sympathetic nervous system activity). However, the evidence of an association between the primary mediators of AL and MetS is limited. This systematic review aimed to critically examine the association between the primary mediators of AL and MetS. PubMed and Web of Science were searched for articles from January 2010 to December 2021, published in English. The search strategy focused on cross-sectional and case-control studies comprising adult participants with MetS, obesity, overweight, and without chronic diseases. The STROBE checklist was used to assess study quality control. Of 770 studies, twenty-one studies with a total sample size (n = 10,666) met the eligibility criteria. Eighteen studies were cross-sectional, and three were case-control studies. The included studies had a completeness of reporting score of COR % = 87.0 & PLUSMN; 6.4%. It is to be noted, that cortisol as a primary mediator of AL showed an association with MetS in 50% (urinary cortisol), 40% (serum cortisol), 60% (salivary cortisol), and 100% (hair cortisol) of the studies. For DHEAS, it is to conclude that 60% of the studies showed an association with MetS. In contrast, urinary EPI and urinary NE had 100% no association with MetS. In summary, there is a tendency for the association between higher serum cortisol, salivary cortisol, urinary cortisol, hair cortisol, and lower levels of DHEAS with MetS. Future studies focusing on longitudinal data are warranted for clarification and understanding of the association between the primary mediators of AL and MetS.
C1 [Osei, Francis; Block, Andrea; Wippert, Pia-Maria] Univ Potsdam, Dept Hlth & Phys Act, Med Sociol & Psychobiol, Brandenburg, Germany.
C3 University of Potsdam
RP Osei, F (corresponding author), Univ Potsdam, Dept Hlth & Phys Act, Med Sociol & Psychobiol, Brandenburg, Germany.
EM francis.osei@uni-potsdam.de
RI Wippert, Pia-Maria/AAJ-6989-2020
OI Block, Andrea/0000-0002-4819-2529
FU Open Access Publishing Fund by the Deutsche Forschungsgemeinschaft (DFG,
   German Research Foundation) [491466077]; DAAD [57552340]
FX The funder does not influence data collection, analysis, and
   interpretation or writing of the manuscript. The authors declare that
   they have no competing interests. The paper was funded by the Open
   Access Publishing Fund by the Deutsche Forschungsgemeinschaft (DFG,
   German Research Foundation)-Projektnummer 491466077. The present study
   was supported by a scholarship from DAAD (grant-number: 57552340) to
   Francis Osei.
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NR 84
TC 5
Z9 6
U1 1
U2 3
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD NOV 22
PY 2022
VL 13
AR 946740
DI 10.3389/fendo.2022.946740
PG 16
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 6T8ZI
UT WOS:000893962800001
PM 36482995
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Li, BR
   Huang, H
   Zhao, J
   Deng, XR
   Zhang, ZL
AF Li, Borui
   Huang, Hong
   Zhao, Juan
   Deng, Xuerong
   Zhang, Zhuoli
TI Discrepancy in Metabolic Syndrome between Psoriatic Arthritis and
   Rheumatoid Arthritis: a Direct Comparison of Two Cohorts in One Center
SO RHEUMATOLOGY AND THERAPY
LA English
DT Article
DE Psoriatic arthritis; Rheumatoid arthritis; Metabolic syndrome; Coronary
   artery disease; Disease activity
ID DIABETES-MELLITUS; RISK-FACTORS; DISEASE-ACTIVITY; LIPID-LEVELS;
   INFLAMMATION; ASSOCIATION; OBESITY; POPULATION; STRESS
AB Objective We aimed to investigate the discrepancy in metabolic syndrome (MS) and cardiovascular disease (CVD) between patients with psoriatic arthritis (PsA) and those with rheumatoid arthritis (RA). Methods Patients with PsA and RA were enrolled between 1 December 2018 and 31 December 2021. Data on their demographics, height, weight, waist circumference, clinical and laboratory data, and comorbidities were collected. Disease activities of patients with RA and PsA were assessed. Prevalence was estimated by dividing cases (such as MS and CVD) of PsA and RA individually. Propensity score matching and inverse probability of treatment weighting were used for further validation. Results Consecutively, 197 patients with PsA and 279 patients with RA were enrolled in this study. Both MS [36.0% versus 23.3%, p = 0.002, OR 1.54 (1.16, 2.05)] and CVD [6.6% versus 1.1%, p = 0.001, OR 6.13 (1.77, 21.25)] were more frequently observed in patients with PsA compared with patients with RA. The frequency of abdominal obesity was also higher in patients with PsA [61.9% versus 33.0%, OR 1.87 (1.53, 2.29), p < 0.001]. After 1:1 propensity score matching for age, sex, smoking history, serum lipids, and disease activity, MS remained more common in 117 patients with PsA than in 117 patients with RA (37.6% versus 23.1%, p = 0.016) These findings remained after the inverse probability of treatment weighting in 196 patients with PsA and 288 patients with RA. A positive linear relationship between MS with disease activity was found in patients with PsA, but not in patients with RA. Conclusion Considerable discrepancies in MS and CVD were observed between patients with PsA and those with RA. The greater odds of MS and CVD emphasize the need to pay more attention to metabolic and cardiovascular conditions in patients with PsA.
C1 [Li, Borui; Huang, Hong; Zhao, Juan; Deng, Xuerong; Zhang, Zhuoli] Peking Univ First Hosp, Dept Rheumatol & Clin Immunol, Beijing 100034, Peoples R China.
RP Zhang, ZL (corresponding author), Peking Univ First Hosp, Dept Rheumatol & Clin Immunol, Beijing 100034, Peoples R China.
EM zhuoli.zhang@126.com
RI Li, Borui/KWL-4838-2024; zhao, juan/KHC-8840-2024
FU National Natural Science Foundation of China [2019CR28];  [81771740]; 
   [81801611];  [81971524]
FX This work and the journal's Rapid Service Fee were supported by the
   youth clinical research project of Peking University First Hospital
   (2019CR28) and the National Natural Science Foundation of China (nos.
   81771740, 81801611, 81971524). Declaration of 1964 and its later
   amendments or comparable ethical standards.
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NR 50
TC 5
Z9 5
U1 0
U2 8
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 2198-6576
EI 2198-6584
J9 RHEUMATOL THER
JI Rheumatol. Ther.
PD FEB
PY 2023
VL 10
IS 1
BP 135
EP 148
DI 10.1007/s40744-022-00502-4
EA OCT 2022
PG 14
WC Rheumatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Rheumatology
GA 9B8LW
UT WOS:000870617800001
PM 36264448
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Nguyen, HD
   Kim, MS
AF Nguyen, Hai Duc
   Kim, Min-Sun
TI Effects of heavy metal, vitamin, and curry consumption on metabolic
   syndrome during menopause: a Korean community-based cross-sectional
   study
SO MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY
LA English
DT Article
DE Cadmium; Curry consumption; Menopause; Metabolic syndrome; Vitamin B2
ID OXIDATIVE STRESS; NATIONAL-HEALTH; DIABETES-MELLITUS; URINARY CADMIUM;
   BLOOD-PRESSURE; MERCURY LEVELS; RISK-FACTORS; ASSOCIATION; GLUCOSE;
   EXPOSURE
AB Objective: To determine the associations between metabolic syndrome (MetS) during menopause and serum heavy metal levels and vitamin and curry consumption.
   Methods: A data set of 7,131 pre- and postmenopausal women aged >= 20 years collected between 2009 and 2017 was used to obtain information on sociodemographic, lifestyles, family histories, food intakes, and serum heavy metal levels and MetS. Logistic regression was used to identify associations between the presence of MetS and risk factors and to predict risks of MetS based on marginal effects.
   Results: Our results show that postmenopausal women had a higher risk of MetS than premenopausal women. During postmenopause elevations in the levels of serum cadmium by one unit increased the risk of MetS by 33% (OR 1.33; 95% CI, 1.03-1.72, P = 0.028). Risks of MetS in pre- and postmenopausal women, when serum Hb levels increased by 1 unit increased 21% (OR 1.21; 95% CI, 1.09-1.33, P < 0.001) and 26% (OR 1.26; 95% CI, 1.16-1.38, P < 0.001), respectively. Furthermore, the risk of MetS risk in pre- and postmenopausal women was increased 2.49-fold and 2.79-fold by a 1% increase in HbA1c level (OR 2.49; 95% CI, 1.97-3.16, P < 0.001) and (OR 2.79; 95% CI, 2.30-3.38, P < 0.001), respectively. High curry consumption reduced the risk of MetS significantly more than low curry consumption (OR 0.60; 95% CI, 0.39-0.91, P = 0.017) in premenopausal women. Furthermore, an increase in daily vitamin B2 intake by 1 mg reduced the risk of MetS by 45% (OR 0.55; 95% CI, 0.32-0.94, P = 0.028) in postmenopausal women.
   Conclusion: Vitamin B2 and curry supplementation may protect against MetS. Further work is needed to reduce risk factors associated with heavy metals and determine the effects of vitamins and curry consumption on MetS during menopause.
C1 [Nguyen, Hai Duc; Kim, Min-Sun] Sunchon Natl Univ, Coll Pharm, Dept Pharm, Sunchon 57922, Jeonnam, South Korea.
   [Nguyen, Hai Duc] Sunchon Natl Univ, Res Inst Life & Pharmaceut Sci, Sunchon, Jeonnam, South Korea.
C3 Sunchon National University; Sunchon National University
RP Kim, MS (corresponding author), Sunchon Natl Univ, Coll Pharm, Dept Pharm, Sunchon 57922, Jeonnam, South Korea.
EM minsun@scnu.ac.kr
RI Nguyen Duc, Hai/AAD-8210-2020
OI Nguyen Duc, Hai/0000-0001-8419-7784
FU Sunchon National University
FX This work was supported by a Research Grant from Sunchon National
   University.
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NR 64
TC 33
Z9 34
U1 1
U2 7
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1072-3714
EI 1530-0374
J9 MENOPAUSE
JI Menopause-J. N. Am. Menopause Soc.
PD AUG
PY 2021
VL 28
IS 8
BP 949
EP 959
DI 10.1097/GME.0000000000001825
PG 11
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA TR2DF
UT WOS:000678780400016
PM 34284432
DA 2025-06-11
ER

PT J
AU Kim, J
   Yoon, DW
   Lee, SK
   Lee, S
   Choi, KM
   Robert, TJ
   Shin, C
AF Kim, Jinkwan
   Yoon, Dae Wui
   Lee, Seung Ku
   Lee, Seunggwan
   Choi, Kyung-Mee
   Robert, Thomas J.
   Shin, Chol
TI Concurrent presence of inflammation and obstructive sleep apnea
   exacerbates the risk of metabolic syndrome A KoGES 6-year follow-up
   study
SO MEDICINE
LA English
DT Article
DE cardiovascular disease; high-sensitivity C-reactive protein;
   inflammation; metabolic syndrome; obstructive sleep apnea
ID C-REACTIVE PROTEIN; CARDIOVASCULAR-DISEASE; GLUCOSE-METABOLISM;
   INSULIN-RESISTANCE; CHILDREN; OBESITY; ASSOCIATION; PREVALENCE; CRP;
   INTERLEUKIN-6
AB Obstructive sleep apnea (OSA) leads to multiple end-organ morbidities that are mediated by the cumulative burden of oxidative stress and inflammation. Both OSA and inflammation play key roles in increased risk of cardiovascular disease (CVD). Thus, we hypothesized that the combination of inflammation and OSA could accelerate the development of metabolic syndrome (MetS) in a large cohort study.
   A total of 1835 participants were randomly selected from the ongoing Korean Genome and Epidemiology Study for the years between 2007 and 2015. Overnight polysomnography was performed on each participant. Blood was drawn for biochemical analyses. Participants with high or low inflammation were divided by high-sensitivity C-reactive protein (hsCRP). MetS was defined using the criteria of the modified National Cholesterol Education Program, Adult Treatment Panel III.
   The prevalence of MetS was higher among the subjects with OSA and high hsCRP levels than among the other corresponding groups. The incidence of MetS among the 4 groups stratified by OSA and inflammation status at the 6-year follow-up was 11.8%, 19.9%, 25.8%, and 36.0%(HsCRP[-]/OSA[-] vsHsCRP[+]/OSA[-] vsHsCRP[-]/OSA[+] vs HsCRP[+]/OSA[+], P < 0.01). After adjusting for age, sex, smoking, alcohol status, BMI, and change inBMI (Delta BMI) in amultiple logistic regression, the subjects with OSA and high hsCRP levels at follow-up had a 2.22-fold risk of developing MetS, as compared with those with no-OSA and low hsCRP levels (P< 0.01).
   MetS is more prevalent in the concurrent presence of inflammation and OSA. The combination of these conditions is associated with higher risk of MetS. Additional research is needed to help further define the significance of the combined effect of OSA and subclinical inflammation on the development of MetS in the context of reduction of CVD risk.
C1 [Kim, Jinkwan] Jungwon Univ, Dept Biomed Lab Sci, Coll Hlth Sci, Geo San, South Korea.
   [Yoon, Dae Wui; Lee, Seung Ku; Choi, Kyung-Mee; Shin, Chol] Korea Univ, Ansan Hosp, Inst Human Genom Study, Ansan, South Korea.
   [Lee, Seunggwan] Korea Univ, Dept Hlth & Integrat Sci, Coll Hlth Sci, Seoul, South Korea.
   [Robert, Thomas J.] Beth Israel Deaconess Med Ctr, Dept Med, Div Pulm Crit Care & Sleep Med, Boston, MA 02215 USA.
   [Shin, Chol] Korea Univ, Coll Med, Dept Pulm Sleep & Crit Care Med, Disorder Ctr, Ansan, South Korea.
C3 Jungwon University; Korea University; Korea University Medicine (KU
   Medicine); Korea University; Harvard University; Harvard University
   Medical Affiliates; Beth Israel Deaconess Medical Center; Korea
   University; Korea University Medicine (KU Medicine)
RP Shin, C (corresponding author), Korea Univ, Ansan Hosp, Dept Internal Med, Div Pulm Sleep & Crit Care Med, 516,Gojan 1 Dong, Ansan 425707, Gyeonggi Do, South Korea.; Shin, C (corresponding author), Korea Univ, Inst Human Genom Study, 516,Gojan 1 Dong, Ansan 425707, Gyeonggi Do, South Korea.
EM chol-shin@korea.ac.kr
RI Lee, Sun-Ho/AAD-6712-2022; Kim, Jinyoung/LFS-2554-2024; lee,
   seungku/GSN-5012-2022
OI Kim, Jinkwan/0000-0002-7123-1354
FU Korea Centers for Disease Control and Prevention [2007-E71001-00,
   2008-E71001-00, 2009-E71002-00, 2010-E71001-00, 2011-E71004-00,
   2012-E71005-00, 2013-E71005-00, 2014-E71003-00]
FX This research was supported by a fund (Grants 2007-E71001-00,
   2008-E71001-00, 2009-E71002-00, 2010-E71001-00, 2011-E71004-00,
   2012-E71005-00, 2013-E71005-00, 2014-E71003-00) from the Korea Centers
   for Disease Control and Prevention.
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NR 55
TC 22
Z9 22
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD FEB
PY 2017
VL 96
IS 7
AR e4488
DI 10.1097/MD.0000000000004488
PG 9
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA EL2EL
UT WOS:000394432800001
PM 28207497
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Hussein, AMS
   Fouda, K
   Mehaya, FM
   Mohamed, DA
   Mohammad, AA
   Abdelgayed, SS
   Mohamed, RS
AF Hussein, Ahmed M. S.
   Fouda, Karem
   Mehaya, Fathy M.
   Mohamed, Doha A.
   Mohammad, Ayman A.
   Abdelgayed, Sherein S.
   Mohamed, Rasha S.
TI Fortified vegetarian milk for prevention of metabolic syndrome in rats:
   impact on hepatic and vascular complications
SO HELIYON
LA English
DT Article
DE Food science; Nutrition; Metabolic syndrome; Cardiovascular diseases;
   Fruits and vegetables; Quinoa almond milk
ID CARDIOVASCULAR RISK-FACTORS; IN-VITRO ANTIOXIDANT; INSULIN-RESISTANCE;
   ALMOND CONSUMPTION; PPAR-GAMMA; SERUM; DIET; REDUCTION; CAPACITY; ALPHA
AB Metabolic syndrome (MetS) is characterized as a gathering of various metabolic disorders, for example, hyperglycemia, dyslipidemia, and obesity. The present research was conducted to prepare fortified almond milk as functional beverages and evaluate their protective effect against MetS and associated hepatic and vascular complications. Three beverages (I, II, and III) were prepared by fortification almond milk with carrot juice or powder of quinoa seeds and carrot juice or oat powder and banana juice. The sensory attributes, physicochemical properties, bioactive compounds (total phenolic, beta-carotene, tocopherols) and B-complex vitamins were determined in the beverages. In-vitro antioxidant activity of the beverages was assessed. MetS was induced in rats via feeding on high-fat high-fructose diet (HFHF). The biochemical (lipid profile, oxidative stress, liver, and kidney functions), nutritional and histopathological parameters were assessed in rats. The beverage I recorded the highest sensory attributes' scores. The physicochemical properties of the beverages revealed that acidity and viscosity of all beverages ranged from 4.55 to 4.88 and from 40 to 59, respectively. The beverage I showed the highest content of alpha-tocopherol (14.994 mu g/g) and beta-carotene (104.541 mu g/g), while the beverage II showed the highest content of gamma-tocopherol (0.557 mu g/g), folic acid (0.806 mu g/g), and total phenols (147.43 mu g GAE/g). The results of animals revealed that the beverage II was the most promising in attenuation levels of total cholesterol, triglycerides, low-density lipoprotein cholesterol, malondialdehyde, and tumor necrosis factor alpha. Also, the beverage II was the superior in the protection of the liver and heart tissues as reflected by the histopathological examination findings. So, it can be concluded that the newly prepared almond milk with quinoa seeds and carrot juice could be used as an effective functional beverage for the prevention of MetS and its complications.
C1 [Hussein, Ahmed M. S.; Mehaya, Fathy M.; Mohammad, Ayman A.] Natl Res Ctr, Food Technol Dept, Cairo, Egypt.
   [Fouda, Karem; Mohamed, Doha A.; Mohamed, Rasha S.] Natl Res Ctr, Nutr & Food Sci Dept, Cairo, Egypt.
   [Abdelgayed, Sherein S.] Cairo Univ, Fac Vet Med, Pathol Dept, Cairo, Egypt.
C3 Egyptian Knowledge Bank (EKB); National Research Centre (NRC); Egyptian
   Knowledge Bank (EKB); National Research Centre (NRC); Egyptian Knowledge
   Bank (EKB); Cairo University
RP Fouda, K (corresponding author), Natl Res Ctr, Nutr & Food Sci Dept, Cairo, Egypt.
EM karemfouda2006@yahoo.com
RI Fouda, Karem/AAZ-1256-2021; Mohammad, Ayman/AAW-2000-2020; Mohamed,
   Rasha/AAW-1896-2020; Mohamed, Doha/AAZ-2024-2020; Mehaya,
   Fathy/GRN-7799-2022; Salem, Sherein/K-7031-2019
OI Mehaya, Fathy/0000-0001-8434-1029; Fouda, Karem/0000-0001-7018-4202;
   Mohammad, Ayman/0000-0001-6114-4217; Salah Mohamed,
   Rasha/0000-0003-4223-000X; Mohamed, Doha/0000-0003-0606-9378; Salem,
   Sherein/0000-0003-3274-0209
FU National Research Centre, Egypt
FX The research was funded by National Research Centre, Egypt.
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NR 86
TC 9
Z9 9
U1 3
U2 10
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
EI 2405-8440
J9 HELIYON
JI Heliyon
PD AUG
PY 2020
VL 6
IS 8
AR e04593
DI 10.1016/j.heliyon.2020.e04593
PG 11
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA NN4IM
UT WOS:000568753100024
PM 32793828
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Park, JK
   Woo, HW
   Kim, MK
   Shin, J
   Lee, YH
   Shin, DH
   Shin, MH
   Choi, BY
AF Park, Jin-Kyu
   Woo, Hye Won
   Kim, Mi Kyung
   Shin, Jinho
   Lee, Young-Hoon
   Shin, Dong Hoon
   Shin, Min-Ho
   Choi, Bo Youl
TI Dietary iodine, seaweed consumption, and incidence risk of metabolic
   syndrome among postmenopausal women: a prospective analysis of the
   Korean Multi-Rural Communities Cohort Study (MRCohort)
SO EUROPEAN JOURNAL OF NUTRITION
LA English
DT Article
DE Iodine intake; Seaweed; Metabolic syndrome; Prospective; Postmenopausal
   women
ID CORONARY-HEART-DISEASE; TOTAL-ENERGY INTAKE; CARDIOVASCULAR-DISEASE;
   OXIDATIVE STRESS; DIABETES-MELLITUS; URINARY IODINE; OBESITY; EXCESS;
   VALIDATION; POISSON
AB Purpose Despite a beneficial role of iodine and seaweed consumption against metabolic syndrome (MetS), which is high in postmenopausal women, few studies investigated such associations in a prospective study. This study aimed to investigate the association of dietary iodine and seaweed consumption with the incidence of MetS and its components in postmenopausal women. Methods A total of 2588 postmenopausal women aged >= 40 years were recruited between 2005 and 2011 in the Multi-Rural Communities Cohort (MRCohort). A validated semiquantitative food frequency questionnaire was used to collect dietary intake data. MetS was defined as three of five components [abdominal obesity, elevated blood pressure, glucose, triglyceride, and low-high density lipoprotein cholesterol (HDL-C)] and the incidence of MetS was checked every 2-4 years. The incidence rate ratio (IRR) was estimated using a modified Poisson regression model with a robust error estimator. Results During the mean follow-up period (3.4 +/- 2.1 years), MetS occurred in 481 participants. The median cumulative average iodine intake was 108.9 mu g/day (interquartile range, 60.8-190.2 mu g/day). In multivariable analyses, average iodine and seaweed consumption were inversely associated with MetS (IRR = 0.61, 95% CI 0.47-0.78 in the highest quartile of iodine intake, P for trend = 0.0018; IRR = 0.52, 95% CI 0.39-0.69 in the highest quartile of seaweed consumption, P for trend = 0.0004). Among MetS components, blood glucose (> 100 mg/dL), blood pressure (>= 130/85 mmHg), and lipid profiles (triglyceride, >= 150 mg/dL and HDL-C, < 50 mg/dL) were significantly inversely associated with dietary iodine and seaweed consumption, but there was no clear association for waist circumference (>= 85 cm). Conclusion Dietary iodine and seaweed consumption may be inversely associated with MetS incidence and its individual abnormalities in postmenopausal women.
C1 [Park, Jin-Kyu; Shin, Jinho] Hanyang Univ, Div Cardiol, Dept Internal Med, Coll Med, Seoul, South Korea.
   [Woo, Hye Won; Choi, Bo Youl] Hanyang Univ, Dept Prevent Med, Coll Med, Seoul, South Korea.
   [Kim, Mi Kyung] Hanyang Univ, Med Sch, Dept Prevent Med, Coll Med, Bldg A,Room 517-2,222 Wangsimni Ro, Seoul 04763, South Korea.
   [Kim, Mi Kyung; Choi, Bo Youl] Hanyang Univ, Inst Hlth & Soc, Seoul, South Korea.
   [Lee, Young-Hoon] Wonkwang Univ, Sch Med, Dept Prevent Med, Iksan, South Korea.
   [Lee, Young-Hoon] Wonkwang Univ, Sch Med, Inst Wonkwang Med Sci, Iksan, South Korea.
   [Shin, Dong Hoon] Keimyung Univ, Sch Med, Dept Prevent Med, Daegu, South Korea.
   [Shin, Min-Ho] Chonnam Natl Univ, Med Sch, Dept Prevent Med, Gwangju, South Korea.
C3 Hanyang University; Hanyang University; Hanyang University; Hanyang
   University; Wonkwang University; Wonkwang University; Keimyung
   University; Chonnam National University
RP Kim, MK (corresponding author), Hanyang Univ, Med Sch, Dept Prevent Med, Coll Med, Bldg A,Room 517-2,222 Wangsimni Ro, Seoul 04763, South Korea.; Kim, MK (corresponding author), Hanyang Univ, Inst Hlth & Soc, Seoul, South Korea.
EM kmkkim@hanyang.ac.kr
RI Woo, HyeWon/LMO-9223-2024; Kim, Mi-Kyung/E-8682-2012
OI Shin, Min-Ho/0000-0002-2217-5624; Kim, Mi Kyung/0000-0001-8503-2631;
   Shin, Jinho/0000-0001-6706-6504; Woo, Hye Won/0000-0001-6072-6119; Park,
   Jin-Kyu/0000-0001-7931-777X; Lee, Young-Hoon/0000-0003-1367-025X; Choi,
   Bo Youl/0000-0003-0115-5736
FU Korea Centers for Disease Control and Prevention [2004-E71004-00,
   2005-E71011-00, 2006-E71009-00, 2007-E71002-00, 2008-E71004-00,
   2009-E71006-00, 2010-E71003-00, 2011-E71002-00, 2012-E71007-00,
   2013-E71008-00]; National Research Foundation of Korea - Korean
   government (Ministry of Science, ICT & Future Planning)
   [2016R1A2B2011352]
FX This work was supported by the Research Program, funded by the Korea
   Centers for Disease Control and Prevention (2004-E71004-00,
   2005-E71011-00, 2006-E71009-00, 2007-E71002-00, 2008-E71004-00,
   2009-E71006-00, 2010-E71003-00, 2011-E71002-00, 2012-E71007-00,
   2013-E71008-00), and by a National Research Foundation of Korea grant
   funded by the Korean government (Ministry of Science, ICT & Future
   Planning) (No. 2016R1A2B2011352).
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NR 56
TC 15
Z9 15
U1 0
U2 11
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1436-6207
EI 1436-6215
J9 EUR J NUTR
JI Eur. J. Nutr.
PD FEB
PY 2021
VL 60
IS 1
BP 135
EP 146
DI 10.1007/s00394-020-02225-0
EA MAR 2020
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA QD5RS
UT WOS:000521726500001
PM 32211932
DA 2025-06-11
ER

PT J
AU Faris, MAIE
   Jahrami, HA
   Alsibai, J
   Obaideen, AA
AF Faris, Mo'ez Al-Islam' E.
   Jahrami, Haitham A.
   Alsibai, Joud
   Obaideen, Asma A.
TI Impact of Ramadan diurnal intermittent fasting on the metabolic syndrome
   components in healthy, non-athletic Muslim people aged over 15 years: a
   systematic review and meta-analysis
SO BRITISH JOURNAL OF NUTRITION
LA English
DT Review
DE Energetic restriction; Intermittent fasting; The metabolic syndrome;
   Meta-analysis; Ramadan; Systematic review; Time-restricted feeding
ID DENSITY-LIPOPROTEIN-CHOLESTEROL; SERUM-LIPID PROFILES; BODY-COMPOSITION;
   HEMATOLOGICAL PARAMETERS; BIOCHEMICAL PARAMETERS; BLOOD-PRESSURE;
   OXIDATIVE STRESS; WEIGHT-LOSS; HOLY MONTH; DIET
AB Studies on the impact of Ramadan diurnal intermittent fasting (RDIF) on the metabolic syndrome (MetS) components among healthy Muslims observing Ramadan month have yielded contradictory results. This comprehensive meta-analysis aimed to obtain a more stable estimate of the effect size of fasting during Ramadan on the MetS components, examine variability among studies, assess the generalisability of reported results and perform subgroup analyses for associated factors. We searched the CINAHL, Cochrane, EBSCOhost, Google Scholar, ProQuest Medical, PubMed/MEDLINE, ScienceDirect, Scopus and Web of Science databases for relevant studies published from 1950 to March 2019. The MetS components analysed were: waist circumference (WC), systolic blood pressure (SBP), fasting plasma/serum glucose (FG), TAG, and HDL-cholesterol. We identified eighty-five studies (4326 participants in total) that were conducted in twenty-three countries between 1982 and 2019. RDIF-induced effect sizes for the MetS components were: small reductions in WC (no. of studies K = 24, N 1557, Hedges' g = -0 center dot 312, 95 % CI -0 center dot 387, -0 center dot 236), SBP (K = 22, N 1172, Hedges' g = -0 center dot 239, 95 % CI -0 center dot 372, -0 center dot 106), FG (K = 51, N 2318, Hedges' g = -0 center dot 101, 95 % CI -0 center dot 260, 0 center dot 004) and TAG (K = 63, N 2862, Hedges' g = -0 center dot 088, 95 % CI -0 center dot 171, -0 center dot 004) and a small increase in HDL-cholesterol (K = 57, N 2771, Hedges' g = 0 center dot 150, 95 % CI 0 center dot 064, 0 center dot 236). We concluded that among healthy people, RDIF shows small improvement in the five MetS components: WC, SBP, TAG, FG and HDL.
C1 [Faris, Mo'ez Al-Islam' E.; Alsibai, Joud; Obaideen, Asma A.] Univ Sharjah, Dept Clin Nutr & Dietet, Coll Hlth Sci, RIMHS, Sharjah, U Arab Emirates.
   [Jahrami, Haitham A.] Minist Hlth, Periphery Hosp, Dept Rehabil Serv, Manama, Bahrain.
   [Jahrami, Haitham A.] Arabian Gulf Univ, Coll Med & Med Sci, Dept Psychiat, Manama, Bahrain.
   [Obaideen, Asma A.] Univ Putra Malaysia, Fac Med & Hlth Sci, Dept Clin Nutr, Seri Kernbangan 443400, Malaysia.
C3 University of Sharjah; Ministry of Health - Bahrain; Arabian Gulf
   University; Universiti Putra Malaysia
RP Faris, MAIE (corresponding author), Univ Sharjah, Dept Clin Nutr & Dietet, Coll Hlth Sci, RIMHS, Sharjah, U Arab Emirates.
EM mfaris@sharjah.ac.ae
RI Jahrami, Haitham/JVO-6632-2024; Faris, MoezAlIslam/M-9682-2017
OI Jahrami, Haitham/0000-0001-8990-1320; Faris,
   MoezAlIslam/0000-0002-7970-2616
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NR 139
TC 80
Z9 81
U1 0
U2 25
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1145
EI 1475-2662
J9 BRIT J NUTR
JI Br. J. Nutr.
PD JAN 14
PY 2020
VL 123
IS 1
BP 1
EP 22
AR PII S000711451900254X
DI 10.1017/S000711451900254X
PG 22
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA JY9II
UT WOS:000504719400001
PM 31581955
OA Bronze
DA 2025-06-11
ER

PT J
AU Kim, HJ
   Lee, J
   Chae, DW
   Lee, KB
   Sung, SA
   Yoo, TH
   Han, SH
   Ahn, C
   Oh, KH
AF Kim, Hyo Jin
   Lee, Joongyub
   Chae, Dong-Wan
   Lee, Kyu-Beck
   Sung, Su Ah
   Yoo, Tae-Hyun
   Han, Seung Hyeok
   Ahn, Curie
   Oh, Kook-Hwan
TI Serum klotho is inversely associated with metabolic syndrome in chronic
   kidney disease: results from the KNOW-CKD study
SO BMC NEPHROLOGY
LA English
DT Article
DE Chronic kidney disease; Klotho; Metabolic syndrome
ID CARDIOVASCULAR RISK; OXIDATIVE STRESS; GENE; EXPRESSION; DIAGNOSIS
AB Background: Metabolic syndrome (MS) is prevalent in chronic kidney disease (CKD). Klotho, a protein linked to aging, is closely associated with CKD. Each component of MS and klotho has an association. However, little is known about the association between klotho and MS per se. We investigated the association between serum klotho levels and MS using baseline cross-sectional data obtained from a large Korean CKD cohort.
   Methods: Of the 2238 subjects recruited in the KoreaN Cohort Study for Outcome in Patients With Chronic Kidney Disease (KNOW-CKD) between 2011 and 2016, 484 patients with missing data on serum klotho and extreme klotho values (values lower than the detectable range or > 6000 pg/mL) or with autosomal dominant polycystic kidney disease patients were excluded. The data of the remaining 1754 subjects were included in the present study. MS was defined using the revised National Cholesterol Education Program Adult Treatment Panel (NCEP-ATP) III criteria. Serum klotho levels were measured using an enzyme-linked immunosorbent assay.
   Results: Mean patient age was 54.9 +/- 12.1 years and 1110 (63.3%) were male. The prevalence of MS among all study subjects was 63.7% (n = 1118). The median serum klotho level was 527 pg/mL (interquartile range [IQR]: 418-656 pg/mL). Serum klotho level was significantly lower in MS patients than patients without MS (Median [IQR]; 521 pg/mL [413, 651] vs. 541 pg/mL [427, 676], respectively; P = 0.012). After adjusting for age, sex, estimated glomerular filtration rate, and overt proteinuria, serum klotho was independently associated with MS (adjusted odds ratio [OR], 0.44; 95% confidence interval, 0.23-0.82; P = 0.010). Furthermore, the adjusted OR for MS was found to be significantly increased at serum klotho levels of < 518 pg/mL (receiver operating characteristic curve cut-off value).
   Conclusions: Serum klotho was inversely associated with the presence of MS in patients with CKD.
C1 [Kim, Hyo Jin] Dongguk Univ, Coll Med, Dept Internal Med, Gyeongju Si, Gyeongsangbuk D, South Korea.
   [Lee, Joongyub] Inha Univ, Sch Med, Incheon, South Korea.
   [Lee, Joongyub] Inha Univ Hosp, Dept Prevent & Management, Incheon, South Korea.
   [Chae, Dong-Wan] Seoul Natl Univ, Bundang Hosp, Dept Internal Med, Seongnamsi, Gyeonggi Do, South Korea.
   [Lee, Kyu-Beck] Sungkyunkwan Univ, Sch Med, Kangbuk Samsung Hosp, Dept Internal Med, Seoul, South Korea.
   [Sung, Su Ah] Eulji Univ, Nowon Eulji Med Ctr, Dept Internal Med, Seoul, South Korea.
   [Yoo, Tae-Hyun; Han, Seung Hyeok] Yonsei Univ, Coll Med, Dept Internal Med, Seoul, South Korea.
   [Ahn, Curie; Oh, Kook-Hwan] Seoul Natl Univ, Seoul Natl Univ Hosp, Dept Internal Med, Coll Med, 101 Daehak Ro, Seoul 03080, South Korea.
C3 Dongguk University; Inha University; Inha University; Inha University
   Hospital; Seoul National University (SNU); Sungkyunkwan University
   (SKKU); Samsung Medical Center; Eulji University; Yonsei University;
   Yonsei University Health System; Seoul National University (SNU); Seoul
   National University Hospital
RP Oh, KH (corresponding author), Seoul Natl Univ, Seoul Natl Univ Hosp, Dept Internal Med, Coll Med, 101 Daehak Ro, Seoul 03080, South Korea.
EM khoh@snu.ac.kr
RI Han, Seung/K-4559-2018; Oh, Kook-Hwan/MDS-5373-2025; Chae,
   Dong-Wan/J-5681-2012
OI Oh, Kook-Hwan/0000-0001-9525-2179
FU Korea Center for Disease Control and Prevention [2011E3300300,
   2012E3301100, 2013E3301600, 2013E3301601, 2013E3301602, 2016E3300200]
FX This study was supported by the research program funded by the Korea
   Center for Disease Control and Prevention (2011E3300300, 2012E3301100,
   2013E3301600, 2013E3301601, 2013E3301602, and 2016E3300200).
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NR 40
TC 31
Z9 34
U1 0
U2 0
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1471-2369
J9 BMC NEPHROL
JI BMC Nephrol.
PD APR 3
PY 2019
VL 20
AR 119
DI 10.1186/s12882-019-1297-y
PG 10
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA HU3ME
UT WOS:000465176400002
PM 30943913
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Wang, XN
   Ye, P
   Cao, RH
   Yang, X
   Xiao, WK
   Zhang, Y
   Bai, YY
   Wu, HM
AF Wang, Xiaona
   Ye, Ping
   Cao, Ruihua
   Yang, Xu
   Xiao, Wenkai
   Zhang, Yun
   Bai, Yongyi
   Wu, Hongmei
TI The Association of Homocysteine with Metabolic Syndrome in a
   Community-Dwelling Population: Homocysteine Might Be Concomitant with
   Metabolic Syndrome
SO PLOS ONE
LA English
DT Article
ID 3RD NATIONAL-HEALTH; CARDIOVASCULAR-DISEASE; PLASMA HOMOCYSTEINE;
   ARTERIAL STIFFNESS; SERUM; HYPERHOMOCYSTEINEMIA; INSULIN; RISK; STRESS
AB Objective: Elevated plasma total homocysteine (tHcy) and metabolic syndrome (MetS) are both associated with cardiovascular disease, but the association between tHcy and MetS is not well characterized. The aim of this study was to determine the relationship between tHcy and MetS.
   Methods: To further estimate the time-dependent association of tHcy and MetS, we analyzed the tHcy level and MetS in 1499 subjects from a 4.8-year longitudinal study in Beijing, People's Republic of China.
   Results: In multiple linear regression analysis, baseline tHcy levels associated with age, BMI, SBP, DBP, LDL-C and Cr independently over 4.8-years follow-up; age, BMI, SBP, DBP and Cr were found to be associated with tHcy levels independently at the end of follow-up. Logistic regression analysis showed that there was no association between the baseline tHcy level and MetS over the 4.8-year follow-up (odds ratio (OR), 1.32; 95% confidence interval (CI), 0.79-2.19; P = 0.282); rather, there was an association only with hypertension as a MetS component (OR, 1.53; 95% CI, 1.06-2.21; P = 0.024). tHcy levels were associated with MetS at both cross-sectional baseline (OR, 1.38; 95% CI, 1.02-1.88; P = 0.038) and cross-sectional follow-up (OR, 1.60; 95% CI, 1.02-2.50; P = 0.041). The tHcy levels of MetS subjects were higher than those of non-MetS subjects at both cross-sectional baseline (19.35 +/- 7.92 mu mol/L vs. 17.45 +/- 6.70 mu mol/L, respectively; P = 0.001) and cross-sectional follow-up (18.95 +/- 7.15 mu mol/L vs. 17.11 +/- 5.98 mu mol/L, respectively; P = 0.02).
   Conclusion: The tHcy level was not predictive of the incidence of MetS; however, it may be a risk factor for hypertension as a MetS component. Furthermore, tHcy levels were associated with MetS at cross-sectional baseline and follow-up, which suggests that a higher level of tHcy might be concomitant with MetS.
C1 [Wang, Xiaona; Ye, Ping; Cao, Ruihua; Yang, Xu; Xiao, Wenkai; Zhang, Yun; Bai, Yongyi; Wu, Hongmei] Chinese Peoples Liberat Army Gen Hosp, Dept Geriatr Cardiol, Beijing, Peoples R China.
C3 Chinese People's Liberation Army General Hospital
RP Ye, P (corresponding author), Chinese Peoples Liberat Army Gen Hosp, Dept Geriatr Cardiol, Beijing, Peoples R China.
EM yeping301@sina.com
RI Ye, Pengpeng/AEE-8152-2022
OI Ye, Pengpeng/0000-0002-2924-1436
FU National Nature Science Foundation of China [81270941]; Key National
   Basic Research Program of China [2012CB517503, 2013CB530804]; Key
   Science and Technology Foundation of China [2012ZX09303004-002]
FX This research is supported by the grant from the National Nature Science
   Foundation of China (81270941), the Key National Basic Research Program
   of China (2012CB517503, 2013CB530804) and the Key Science and Technology
   Foundation of China (2012ZX09303004-002) to Dr. Ping Ye. The funders had
   no role in study design, data collection and analysis, decision to
   publish, or preparation of the manuscript.
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Z9 18
U1 1
U2 5
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD NOV 17
PY 2014
VL 9
IS 11
AR e113148
DI 10.1371/journal.pone.0113148
PG 8
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA AT8BL
UT WOS:000345158700117
PM 25401978
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Ma, YL
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   Gao, X
AF Ma, Yu-Lin
   Xia, Ji-Lin
   Gao, Xi
TI Suppressing Irf2bp2 expressions accelerates metabolic
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SO BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
LA English
DT Article
DE Neuroinflammation; High fat diet; Irf2bp2; Cognitive deficit;
   Dyslipidemia
ID HIGH-FAT DIET; INSULIN-RESISTANCE; COGNITIVE FUNCTION; HYPOTHALAMIC
   INFLAMMATION; OBESITY; IMMUNE; MICROGLIA; RATS; NEUROINFLAMMATION;
   INNATE
AB Increasing studies indicate that high fat diet (HFD) induces neuroinflammation in animal models with obesity, yet the pathology of it is unclear. Interferon Regulatory Factor 2 Binding Protein 2 (Irf2bp2) is a key regulator of macrophage polarization, playing an essential role in regulating inflammatory response. This study investigated the effects of lrf2bp2 on HFD-induced brain injury, and explored the possible molecular mechanisms using wild type (WT) and Irf2bp2 knockout (KO) mice. The results indicated that HFD-increased body weight of mice was further elevated by lrf2bp2-knockout. In addition, Irf2bp2-deletion accelerated HFD-induced metabolic syndrome, as evidenced by the promoted fasting glucose and insulin levels. In the results of behavioral measurements, Irf2bp2-knockout intensified cognitive deficit in HFD-fed mice by using Y-maze, passive avoidance, and morris water maze (MWM) tests. Further, Irf2bp2-deficiency accelerated the activation of astrocytes and microglia cells, as evidenced by the promoted expressions of glial fibrillary acidic protein (GFAP) and lba-1 in hippocampus and hypothalamus of HFD-fed mice. HFD for 16 weeks induced oxidative stress in serum and brain of mice, as proved by the up-regulated malondialdehyde (MDA) levels and down-regulated superoxide dismutase (SOD) activity, which were significantly enhanced due to Irf2bp2 knockout. Moreover, HFD-triggered systematic and central nervous inflammation by increasing the release of interleukin 1 beta (IL-1 beta) and tumor necrosis factor (TNF)-alpha, accompanied with elevated p-nuclear factor-kappa B (NF-kappa B) expressions. Notably, HFD-induced inflammation was significantly exacerbated by Irf2bp2 deletion. Intriguingly, HFD-induced dyslipidemia in liver of mice was further aggravated by lrf2bp2 suppression. Our in vitro results verified the effects of Irf2bp2-inhibition on the promotion of inflammatory response in BV2 cells and lipid dysfunction in primary hepatocytes. Therefore, the findings above suggested that inhibiting Irf2bp2 expression provided a potential therapeutic approach for the prevention of metabolic syndrome-associated central nervous injury. (C) 2018 Published by Elsevier Inc.
C1 [Ma, Yu-Lin] Ankang Cent Hosp, Dept Anesthesiol, Ankang 725000, Peoples R China.
   [Xia, Ji-Lin] Ankang Municipal Matern & Child Care, Dept Anesthesiol, Ankang 725000, Peoples R China.
   [Gao, Xi] Xi An Jiao Tong Univ, Intens Care Unit, HongHui Hosp, Xian 710000, Shaanxi, Peoples R China.
C3 Xi'an Jiaotong University
RP Gao, X (corresponding author), Xi An Jiao Tong Univ, Intens Care Unit, HongHui Hosp, Xian 710000, Shaanxi, Peoples R China.
EM gaoxixajt@foxmail.com
RI Ma, Yulin/GRO-5114-2022
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TC 12
Z9 13
U1 0
U2 9
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0006-291X
EI 1090-2104
J9 BIOCHEM BIOPH RES CO
JI Biochem. Biophys. Res. Commun.
PD SEP 10
PY 2018
VL 503
IS 3
BP 1651
EP 1658
DI 10.1016/j.bbrc.2018.07.095
PG 8
WC Biochemistry & Molecular Biology; Biophysics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics
GA GT1IH
UT WOS:000444222100071
PM 30131248
DA 2025-06-11
ER

PT J
AU Yu, SS
   Wang, B
   Li, GX
   Guo, XF
   Yang, HM
   Sun, YX
AF Yu, Shasha
   Wang, Bo
   Li, Guangxiao
   Guo, Xiaofan
   Yang, Hongmei
   Sun, Yingxian
TI Habitual Tea Consumption Increases the Incidence of Metabolic Syndrome
   in Middle-Aged and Older Individuals
SO NUTRIENTS
LA English
DT Article
DE metabolic syndrome; tea consumption; middle-aged; old-aged; elderly;
   rural China
ID CORONARY-HEART-DISEASE; DIETARY IRON INTAKE; SERUM URIC-ACID; GREEN TEA;
   BLOOD-PRESSURE; ENDOTHELIAL DYSFUNCTION; OXIDATIVE STRESS; MEAT INTAKE;
   ALCOHOL-CONSUMPTION; DNA METHYLATION
AB In middle-aged and elderly individuals, the relationship between tea consumption and incident metabolic syndrome (MetS) is still unclear. Therefore, this study intends to figure out the relationship between tea-drinking frequency and MetS in rural middle-aged and older Chinese residents. In the Northeast China Rural Cardiovascular Health Study, 3632 middle-aged or older individuals (mean age 57 +/- 8, 55.2% men) without MetS were included at baseline during 2012-2013 and were followed up on between 2015-2017. Participants showing differential tea consumption frequency were divided into the following classes: non-habitual tea drinkers, occasional tea drinkers, 1-2 times/day drinkers, and >= 3 times/day drinkers. Data showed that non-habitual tea drinking was more common among women. The frequency of tea consumption was higher in ethnic groups other than Han and among singles, as well as in concurrent smokers and drinkers and individuals with primary or lower educational status. The increasing tea consumption was in line with baseline elevations in body mass index, systolic and diastolic blood pressure, high-density lipoprotein cholesterol (HDL-C), and AST/ALT ratio. Multivariate logistic regression analysis confirmed that occasional tea drinking increased the incidence of low HDL-C [OR (95% CI): 1.268 (1.015, 1.584)], high waist circumference [OR (95% CI): 1.336 (1.102, 1.621)], and MetS [OR (95% CI): 1.284 (1.050, 1.570)]. In addition, 1-2 times/day tea drinking increased the cumulative incidence of high TG [OR (95% CI): 1.296 (1.040, 1.616)], high waist circumference [OR (95% CI): 1.296 (1.044, 1.609)] and MetS [OR (95% CI): 1.376 (1.030, 1.760)]. We demonstrated that regular tea consumption is correlated with a greater incidence of metabolic disorders and MetS. Our findings may help clarify the contradictory association reported between tea drinking and MetS development in middle-aged and older residents of rural China.
C1 [Yu, Shasha; Wang, Bo; Guo, Xiaofan; Yang, Hongmei; Sun, Yingxian] China Med Univ, Dept Cardiol, Hosp 1, 155 Nanjing North St, Shenyang 110001, Peoples R China.
   [Li, Guangxiao] China Med Univ, Inst Cardiovasc Dis, Dept Clin Epidemiol, Hosp 1, Shenyang 110001, Peoples R China.
C3 China Medical University; China Medical University
RP Sun, YX (corresponding author), China Med Univ, Dept Cardiol, Hosp 1, 155 Nanjing North St, Shenyang 110001, Peoples R China.
EM sunyingxiancmu1h@163.com
RI Wu, Yang/AFI-0117-2022; Li, Guangxiao/G-5127-2018; Sun,
   Yingxian/KHT-6171-2024
OI Sun, Yingxian/0000-0002-1961-899X
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NR 107
TC 3
Z9 3
U1 0
U2 10
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD MAR
PY 2023
VL 15
IS 6
AR 1448
DI 10.3390/nu15061448
PG 17
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA C0QC0
UT WOS:000959058500001
PM 36986178
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Onat, A
AF Onat, Altan
TI Metabolic syndrome: nature, therapeutic solutions and options
SO EXPERT OPINION ON PHARMACOTHERAPY
LA English
DT Review
DE abdominal obesity; atherogenic dyslipidemia; cardiovascular disease
   risk; diabetes mellitus; HDL dysfunction; metabolic syndrome
ID HIGH-DENSITY-LIPOPROTEIN; C-REACTIVE PROTEIN; CORONARY-HEART-DISEASE;
   TYPE-2 DIABETES-MELLITUS; GAMMA-GLUTAMYL-TRANSFERASE; MODERATE ALCOHOL
   INTAKE; ALL-CAUSE MORTALITY; CARDIOVASCULAR-DISEASE; INSULIN-RESISTANCE;
   RISK-FACTOR
AB Introduction: Metabolic syndrome (MetS) defines the clustering in an individual of multiple metabolic abnormalities, based on central obesity and insulin resistance. In addition to its five components, prothrombotic and proinflammatory states are essential features. The significance of MetS lies in its close association with the risk of type 2 diabetes and cardiovascular disease (CVD). This field being an evolving one necessitated the current review.
   Areas covered: The areas covered in this review include the so far unproven concept that enhanced low-grade inflammation often leads to dysfunction of the anti-inflammatory and atheroprotective properties of apolipoprotein A - I (apoA-I) and HDL particles, which further increases the risk of diabetes and CVD. It was emphasized that lifestyle modification is essential in the prevention and management of MetS, which includes maintenance of optimal weight by caloric restriction, adherence to a diet that minimizes postprandial glucose and triglyceride fluctuations, restricting alcohol consumption, smoking cessation and engaging in regular exercise. Drug therapy should target the dyslipoproteinemia and the often associated hypertension or dysglycemia. Statins are the drugs of first choice, to be initiated in patients with MetS at high 10-year cardiovascular risk. Such treatment is inadequate if fasting serum triglycerides remain at > 150 mg/dl, when niacin should be combined. Fibrates, omega 3 fatty acids, metformin, angiotensin-converting enzyme inhibitors and pioglitazone are additional options in drug therapy.
   Expert opinion: Research on MetS in subpopulations prone to impaired glucose tolerance and insulin resistance has indicated that proinflammatory state and oxidative stress are often prominently involved in MetS, to the extent that evidence of impaired function of HDL and apo A-I particles is discernible by biological evidence of functional defectiveness via outcomes studies and/or correlations with inflammatory and anti-inflammatory biomarkers. A sex difference has been clear in this development.
C1 Istanbul Univ, Cerrahpasa Med Fac, Istanbul, Turkey.
C3 Istanbul University - Cerrahpasa; Istanbul University
RP Onat, A (corresponding author), Istanbul Univ, Cerrahpasa Med Fac, Istanbul, Turkey.
EM alt_onat@yahoo.com.tr
FU Turkish Society of Cardiology
FX The Turkish Society of Cardiology and various pharmaceutical companies
   in Istanbul, Turkey, are gratefully acknowledged for their support of
   the Turkish Adult Risk Factor survey over the years.
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NR 127
TC 79
Z9 85
U1 0
U2 10
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1465-6566
EI 1744-7666
J9 EXPERT OPIN PHARMACO
JI Expert Opin. Pharmacother.
PD AUG
PY 2011
VL 12
IS 12
BP 1887
EP 1900
DI 10.1517/14656566.2011.585462
PG 14
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 792VC
UT WOS:000292777500005
PM 21756201
DA 2025-06-11
ER

PT J
AU Martín-Cordero, L
   García, JJ
   Hinchado, MD
   Bote, E
   Manso, R
   Ortega, E
AF Martin-Cordero, Leticia
   Jose Garcia, Juan
   Dolores Hinchado, Maria
   Bote, Elena
   Manso, Rafael
   Ortega, Eduardo
TI Habitual Physical Exercise Improves Macrophage IL-6 and TNF-α
   Deregulated Release in the Obese Zucker Rat Model of the Metabolic
   Syndrome
SO NEUROIMMUNOMODULATION
LA English
DT Article
DE Exercise; IL-6; Inflammation; Macrophages; Metabolic syndrome; Obesity;
   TNF-alpha
ID NECROSIS-FACTOR-ALPHA; C-REACTIVE PROTEIN; INDUCED STIMULATION;
   ADIPOSE-TISSUE; INFLAMMATION; EXPRESSION; CYTOKINES; STRESS;
   CORTICOSTERONE; MARKERS
AB Objectives: The first objective was to evaluate whether the metabolic syndrome (MS) involves deregulation of TNF-alpha and IL-6 release by non-infiltrated peritoneal macrophages, using obese Zucker rats as the experimental model of MS and lean Zucker rats as a reference for healthy control values. The second purpose was to evaluate in the obese rats the effects of habitual exercise and of a bout of acute exercise on the observed MS-associated deregulation in the release of TNF-alpha and IL-6 by peritoneal macrophages. Methods: The habitual exercise consisted of treadmill running: 5 days/week for 14 weeks and 35 cm/s for 35 min in the last month. The acute exercise consisted of a single session of 25-35 min at 35 cm/s. The constitutive or lipopolysaccharide (LPS)-induced release of TNF-alpha and IL-6 by cultured (24 h, 5% CO2, 100% relative humidity) peritoneal macrophages was determined by ELISA. Results: Macrophages from the obese rats released more IL-6 than those from the lean healthy rats, both spontaneously and after LPS stimulation. However, both spontaneous and LPS-induced release of TNF-alpha was lower in the obese rats. This deregulated balance in the release of IL-6 and TNF-alpha in the obese rats was clearly improved following adherence to the program of habitual exercise, reflected by a decrease in the spontaneous release of IL-6 together with a better regulation between the spontaneous and LPS-induced release of TNF-alpha, approaching the behavior of the lean healthy rats. In addition, an acute bout of exercise decreased the spontaneous release of IL-6 and increased the spontaneous release of TNF-alpha in the sedentary, but not in the exercise-adapted obese rats. Conclusion: MS involves a deregulation of TNF-alpha and IL-6 release by non-infiltrated peritoneal macrophages, which is improved by habitual physical activity. Copyright (C) 2010 S. Karger AG, Basel
C1 [Martin-Cordero, Leticia; Jose Garcia, Juan; Dolores Hinchado, Maria; Bote, Elena; Ortega, Eduardo] Univ Extremadura, Dept Physiol, Fac Sci, Grp Invest Inmunofisiol, ES-06071 Badajoz, Spain.
   [Manso, Rafael] Univ Autonoma Madrid, Fac Ciencias, Dept Biol Mol, E-28049 Madrid, Spain.
C3 Universidad de Extremadura; Autonomous University of Madrid
RP Ortega, E (corresponding author), Univ Extremadura, Dept Physiol, Fac Sci, Grp Invest Inmunofisiol, ES-06071 Badajoz, Spain.
EM orincon@unex.es
RI Ortega, Eduardo/H-9891-2016; Garcia, Juan/C-7383-2013; Martin-Cordero,
   Leticia/H-9711-2015
OI Ortega, Eduardo/0000-0002-7007-7615; Garcia, Juan/0000-0002-8222-4213;
   HINCHADO SANCHEZ-MORO, MARIA DOLORES/0000-0002-9709-4714;
   Martin-Cordero, Leticia/0000-0002-3651-2265; Bote, Maria
   Elena/0000-0002-3112-9259
FU Ministry of Science and Innovation [DEP2006-56187-C04-03]; Junta de
   Extremadura [GRU09004]; FEDER; RETICEF; Fundacion Valhondo de
   Extremadura, Spain
FX This work was partially supported by grants DEP2006-56187-C04-03
   (Ministry of Science and Innovation), GRU09004 (Junta de Extremadura),
   FEDER, RETICEF and Fundacion Valhondo de Extremadura, Spain. We thank
   the specialized personnel from the animal facilities at the Faculty of
   Medicine of the Autonomous University of Madrid for their collaboration.
CR [Anonymous], HEAT SHOCK PROTEINS
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NR 37
TC 15
Z9 16
U1 1
U2 4
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1021-7401
EI 1423-0216
J9 NEUROIMMUNOMODULAT
JI Neuroimmunomodulation
PY 2011
VL 18
IS 2
BP 123
EP 130
DI 10.1159/000322053
PG 8
WC Endocrinology & Metabolism; Immunology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Immunology; Neurosciences & Neurology
GA 690LG
UT WOS:000285005700008
PM 21116112
DA 2025-06-11
ER

PT J
AU Hsiao, PJ
   Kuo, KK
   Shin, SJ
   Yang, YH
   Lin, WY
   Yang, JF
   Chiu, CC
   Chuang, WL
   Tsai, TR
   Yu, ML
AF Hsiao, Pi-Jung
   Kuo, Kung-Kai
   Shin, Shyi-Jang
   Yang, Yi-Hsin
   Lin, Wen-Yi
   Yang, Jeng-Fu
   Chiu, Chao-Chin
   Chuang, Wan-Long
   Tsai, Tong-Rong
   Yu, Ming-Lung
TI Significant correlations between severe fatty liver and risk factors for
   metabolic syndrome
SO JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
LA English
DT Article
DE metabolic syndrome; non-alcoholic fatty liver disease; obesity;
   ultrasonography
ID NECROSIS-FACTOR-ALPHA; NONALCOHOLIC STEATOHEPATITIS; CYTOCHROME-P450
   2E1; HEPATIC STEATOSIS; NATURAL-HISTORY; PACIFIC REGION; FIBROSIS;
   PATHOGENESIS; DISEASE; OBESITY
AB Background and Aim: It is known that ultrasonography (US) cannot differentiate between non-alcoholic fatty liver disease (NAFLD) and steatohepatitis. However, US can accurately estimate the severity of the steatosis. The clinical significance of severe hepatic fatty change by US has not been explored. The aim of this study was to investigate the relationship between the severity of the fatty liver, classified by US, and the degree of metabolic disorders with insulin resistance.
   Methods: In 16 486 Taiwanese patients, severity of fatty change on US was classified as follows: group A (n = 6950), absence of fatty change; group B (n = 8694), mild; and group C (n = 842), severe fatty liver change. Biometabolic parameters included body mass index (BMI), blood pressure (BP), fasting plasma glucose, triglycerides, cholesterol, aspartate aminotransferase (AST), alanine aminotransferase (ALT), and serum creatinine. Nominal logistic regression analysis was used to estimate the odds ratio for different degrees of fatty liver.
   Results: The frequencies of obesity, hypertension, glucose intolerance and hypertriglyceridemia were all significantly higher in group C than in group A or B (P < 0.0001), and the mean values of BMI, BP, fasting glucose, triglyceride and ALT were also higher in group C (P < 0.0001). High BMI (>= 30 kg/m(2)) appears to be the most important factor for progression from mild to severe fatty liver in both sexes.
   Conclusion: The presence of severe fatty liver by US correlated significantly with the prevalence and degree of hypertension, abnormal glucose and triglyceride metabolism. Patients with severe fatty liver could be at an increased risk of atherosclerotic cardiovascular disease and should be screened regularly for metabolic disorders. The physician may also evaluate ALT and hepatic fat content by US in patients with metabolic syndrome. Evaluating the severity of fatty liver by US may be useful because it correlates with the status of hyperinsulinemia, the risks of developing cardiovascular disease, and the threshold for oxidative stress.
C1 Kaohsiung Med Univ, Coll Med, Fac Med,Hepatobiliary Div, Kaohsiung Med Univ Hosp,Dept Internal Med, Kaohsiung, Taiwan.
   Kaohsiung Med Univ, Dept Prevent Med, Kaohsiung, Taiwan.
   Kaohsiung Med Univ, Coll Med, Dept Pharm, Kaohsiung, Taiwan.
   Kaohsiung Med Univ, Coll Med, Grad Inst Med, Kaohsiung, Taiwan.
   Kaohsiung Med Univ, Stat Anal Lab, Dept Clin Res, Kaohsiung, Taiwan.
   Kaohsiung Med Univ, Div Endocrinol & Metab, Kaohsiung, Taiwan.
   Kaohsiung Med Univ, Dept Surg, Kaohsiung, Taiwan.
C3 Kaohsiung Medical University; Kaohsiung Medical University Hospital;
   Kaohsiung Medical University; Kaohsiung Medical University; Kaohsiung
   Medical University; Kaohsiung Medical University; Kaohsiung Medical
   University; Kaohsiung Medical University
RP Yu, ML (corresponding author), Kaohsiung Med Univ Hosp, Dept Internal Med, Div Hepatol, 100 Tzyou 1st Rd, Kaohsiung 807, Taiwan.
EM fishya@ms14.hinet.net
RI Hsiao, Pi-Jung/D-4713-2009; Yu, Ming-Lung/AAZ-4306-2020; Shin,
   Shyi-Jang/A-1523-2010; Tsai, Tong-Rong/C-4962-2009; Huang,
   Jee-Fu/AAX-4622-2020; Yang, Yi-Hsin/D-6471-2012
OI Yang, Yi-Hsin/0000-0002-9581-2778; Yu, Ming-Lung/0000-0001-8145-1900
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NR 44
TC 117
Z9 129
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0815-9319
EI 1440-1746
J9 J GASTROEN HEPATOL
JI J. Gastroenterol. Hepatol.
PD DEC
PY 2007
VL 22
IS 12
BP 2118
EP 2123
DI 10.1111/j.1440-1746.2006.04698.x
PG 6
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 234WI
UT WOS:000251194500015
PM 18031368
OA Bronze
DA 2025-06-11
ER

PT J
AU Mirzababaei, A
   Mollahosseini, M
   Rahimi, MH
   Yekaninejad, MS
   Maghbooli, Z
   Sobhani, R
   Mirzaei, K
AF Mirzababaei, Atieh
   Mollahosseini, Mehdi
   Rahimi, Mohammad Hossein
   Yekaninejad, Mir Saeed
   Maghbooli, Zhila
   Sobhani, Reza
   Mirzaei, Khadijeh
TI Interaction between a variant of chromosome 9p21.3 locus and diet
   antioxidant capacity on metabolic syndrome in Tehrani adults
SO DIABETOLOGY & METABOLIC SYNDROME
LA English
DT Article
DE CDKN2B; Oxygen radical absorbance capacity; Antioxidants; Metabolic
   syndrome; Cardio-vascular diseases; Nutrigenomics
ID SYSTEMIC OXIDATIVE STRESS; CORONARY-HEART-DISEASE; ADIPOSE-TISSUE;
   OBESITY; HYPERTENSION; EXPRESSION; DATABASE; FRUITS; YOUNG
AB BackgroundGenome-wide association studies have shown that risk alleles on chromosome 9p21.3 locus, are associated with increasing the risk of cardiovascular diseases (CVDs). Several epidemiological studies have found that metabolic syndrome (MetS) is associated with CVDs. Dietary antioxidants also have shown to have potential favorable effects on MetS prevention. This study examined the interactions between rs1333048 genotypes on 9p21 genetic region and Total antioxidant capacity (TAC) on odds of MetS.Methods263 Tehrani adults were enrolled in this cross-sectional study. The MetS was defined according to the ATPIII. Dietary intake was assessed daily using a FFQ with 147 items. Dietary TAC was assessed according to United States Department of Agriculture database for oxygen radical absorbance capacity (ORAC). Bioelectrical impedance analysis method was used for body analysis and rs1333048 were genotyped by restriction fragment length polymorphism method. Participants were categorized into three groups based on rs1333048 genotypes.ResultsThe results demonstrate that, prevalence of C allele was 52.85% and A allele was 47.15%. After adjustment for confunder variable, this study demonstrated an interaction between AA genotype and high Lyophilic oxygen radical absorbance capacity (L-ORAC) and high Hydrophilic oxygen radical absorbance capacity (H-ORAC) intake on low odds of MetS (OR=0.24, 95% CI=0.06-0.94, P for interaction=0.04, OR=0.26, 95% CI=0.06-0.99, P for interaction=0.04). Also, our result indicated, there was no interaction between AA genotype and high total oxygen radical absorbance capacity (T-ORAC) and total phenolic intakes on reduce odds of MetS (OR=0.07, 95% CI=0.07-1.10, P for interaction=0.07, OR=0.58, 95% CI=0.16-2.07, P for interaction=0.40) respectively.ConclusionThe results of the present study indicate that high L-ORAC and high H-ORAC intake may modify the elevated odds of MetS in AA genotype of rs1333048 on the 9p21 genetic locus.
C1 [Mirzababaei, Atieh; Mollahosseini, Mehdi; Rahimi, Mohammad Hossein; Sobhani, Reza; Mirzaei, Khadijeh] Tehran Univ Med Sci, Sch Nutr Sci & Dietet, Dept Community Nutr, POB 14155-6117, Tehran, Iran.
   [Mirzababaei, Atieh; Yekaninejad, Mir Saeed] Tehran Univ Med Sci, Sch Publ Hlth, Dept Epidemiol & Biostat, Tehran, Iran.
   [Maghbooli, Zhila] Tehran Univ Med Sci, Endocrinol & Metab Clin Sci Inst, Tehran, Iran.
C3 Tehran University of Medical Sciences; Tehran University of Medical
   Sciences; Tehran University of Medical Sciences
RP Mirzaei, K (corresponding author), Tehran Univ Med Sci, Sch Nutr Sci & Dietet, Dept Community Nutr, POB 14155-6117, Tehran, Iran.
EM mina_mirzaei101@yahoo.com
RI Mirzaei, Khadijeh/D-5408-2018; Sobhani, Seyyed/AFK-6948-2022;
   Mirzababaee, Atieh/AAQ-7191-2020; Mollahosseini, Mehdi/S-6870-2017;
   Yekaninejad, Mir Saeed/L-6752-2016
OI Mollahosseini, Mehdi/0000-0002-9130-1065; Maghbooli,
   Zhila/0000-0001-8858-6269; mirzababaei, atieh/0000-0003-3631-7723;
   Rahimi, Mohammad Hossein/0000-0002-8610-346X; Yekaninejad, Mir
   Saeed/0000-0003-3648-5276; Sobhani, Seyyed Reza/0000-0002-7308-8504
FU Osteoporosis Research Center, Endocrine Diseases and Metabolism Research
   Institute, Tehran University of Medical Sciences; Tehran University of
   Medical Sciences [93-04-161-27-722, 93-04-159-280-31]
FX This study was supported by the Osteoporosis Research Center, Endocrine
   Diseases and Metabolism Research Institute, Tehran University of Medical
   Sciences, and by Grants from Tehran University of Medical Sciences
   (Grants ID: 93-04-161-27-722 and 93-04-159-280-31).
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NR 38
TC 5
Z9 5
U1 0
U2 0
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1758-5996
J9 DIABETOL METAB SYNDR
JI Diabetol. Metab. Syndr.
PD OCT 18
PY 2018
VL 10
AR 76
DI 10.1186/s13098-018-0372-z
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA GX5RC
UT WOS:000447806900001
PM 30364300
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Yu, S
   Feng, WR
   Liang, ZMA
   Zeng, XY
   Bloom, MS
   Hu, GC
   Zhou, Y
   Ou, YQ
   Chu, C
   Li, QQ
   Yu, YJ
   Zeng, XW
   Dong, GH
AF Yu, Shu
   Feng, Wen-Ru
   Liang, Zi-Mian
   Zeng, Xiao-Yun
   Bloom, Michael S.
   Hu, Guo-Cheng
   Zhou, Yang
   Ou, Yan-Qiu
   Chu, Chu
   Li, Qing-Qing
   Yu, Yunjiang
   Zeng, Xiao-Wen
   Dong, Guang-Hui
TI Perfluorooctane sulfonate alternatives and metabolic syndrome in adults:
   New evidence from the Isomers of C8 Health Project in China
SO ENVIRONMENTAL POLLUTION
LA English
DT Article
DE Perfluorooctane sulfonate (PFOS); PFOS alternatives; Metabolic syndrome;
   BKMR; Chlorinated polyfluorinated ether sulfonic acids (Cl-PFESAs)
ID PERFLUOROALKYL SUBSTANCES; POLYFLUOROALKYL SUBSTANCES;
   GLUCOSE-HOMEOSTASIS; OXIDATIVE STRESS; BLOOD-PRESSURE; SERUM ISOMERS;
   ASSOCIATIONS; RISK; EXPOSURE; PFOS
AB Chlorinated polyfluoroalkyl ether sulfonates (Cl-PFESAs), are ubiquitous alternatives to perfluorooctane sulfonate (PFOS), a widely used poly-and perfluoroalkyl substance (PFAS). Despite in vivo and in vitro evidence of metabolic toxicity, no study has explored associations of Cl-PFESAs concentrations with metabolic syndrome (MetS) in a human population. To help address this data gap, we quantified 32 PFAS, including 2 PFOS alternative Cl-PFESAs (6:2 and 8:2 Cl-PFESAs) in serum from 1228 adults participating in the cross-sectional Isomers of C8 Health Project in China study. The odds ratios (ORs) and 95% confidence intervals (CIs) of MetS and its various components were estimated using individual PFAS as a continuous or categorical predictor in multivariate regression models. The association between the overall mixture of PFAS and MetS was examined using probit Bayesian Kernel Machine Regression (BKMR-P). Greater serum PFAS concentrations were associated with higher odds of MetS and demonstrated a statistically significant dose-response trend (P for trend < 0.001). For example, each ln-unit (ng/ mL) increase in serum 6:2 Cl-PFESA was associated with a higher prevalence of MetS (OR = 1.52, 95% CI: 1.25, 1.85). MetS was also 2.26 (95% CI: 1.59, 3.23) times more common in the highest quartile of serum 6:2 Cl-PFESA concentration than the lowest, and particularly high among women (OR = 6.41, 95% CI: 3.65, 11.24). The BKMR-P analysis showed a positive association between the overall mixture of measured PFAS and the odds of MetS, but was only limited to women. While our results suggest that exposure to Cl-PFESAs was associated with MetS, additional longitudinal studies are needed to more definitively address the potential health concerns of these PFOS alternatives.
   0 2021 Elsevier Ltd. All rights reserved.
C1 [Yu, Shu; Chu, Chu; Li, Qing-Qing; Zeng, Xiao-Wen; Dong, Guang-Hui] Sun Yat Sen Univ, Guangdong Prov Engn Technol Res Ctr Environm Poll, Sch Publ Hlth, Dept Occupat & Environm Hlth, 74 Zhongshan 2nd Rd, Guangzhou 510080, Peoples R China.
   [Feng, Wen-Ru] Guangzhou Ctr Dis Control & Prevent, Dept Environm Hlth, Guangzhou 510440, Peoples R China.
   [Liang, Zi-Mian] Foshan Ctr Dis Control & Prevent, Dept Prevent & Control Infect Dis, Foshan 528000, Peoples R China.
   [Zeng, Xiao-Yun] Guangxi Med Univ, Sch Publ Hlth, Dept Epidemiol & Hlth Stat, Nanning 530021, Peoples R China.
   [Bloom, Michael S.] George Mason Univ, Dept Global & Community Hlth, Fairfax, VA 22030 USA.
   [Hu, Guo-Cheng; Zhou, Yang; Yu, Yunjiang] South China Inst Environm Sci, State Environm Protect Key Lab Environm Pollut Hl, Minist Environm Protect, Guangzhou 510655, Peoples R China.
   [Ou, Yan-Qiu] Guangdong Acad Med Sci, Guangdong Prov Peoples Hosp, WHO Collaborating Ctr Res & Training Cardiovasc D, Guangdong Cardiovasc Inst,Dept Epidemiol, Guangzhou 510080, Peoples R China.
C3 Sun Yat Sen University; Guangxi Medical University; George Mason
   University; South China Institute of Environmental Sciences, Ministry of
   Ecology & Environment; Guangdong Academy of Medical Sciences & Guangdong
   General Hospital; Southern Medical University - China
RP Dong, GH (corresponding author), Sun Yat Sen Univ, Guangdong Prov Engn Technol Res Ctr Environm Poll, Sch Publ Hlth, Dept Occupat & Environm Hlth, 74 Zhongshan 2nd Rd, Guangzhou 510080, Peoples R China.
EM donggh5@mail.sysu.edu.cn
RI Bloom, Michael/A-5743-2010; Chu, Chu/T-6038-2019; Guocheng,
   Hu/KGM-3218-2024; Zhou, Yang/LVS-1477-2024; Dong,
   Guanghui/AAN-4630-2020; Ou, Yanqiu/AAJ-6251-2021
OI Zhou, Yang/0000-0003-3365-6631; Bloom, Michael/0000-0002-0028-5494
FU National Natural Science Foundation of China [81673127, 81950410633,
   81972992, 81903287, 81872582, 81872583]; Science and Technology Program
   of Guangzhou [201807010032, 201803010054]; National Key Research and
   Development Program of China [2018YFC1004300, 2018YFE0106900]; Guangdong
   Provincial Natural Science Foundation Team Project [2018B030312005];
   Fundamental Research Funds for the Central Universities [19ykjc01];
   Natural Science Foundation of Guangdong Province [2020A1515011131,
   2019A050510017, 2018B05052007, 2017A090905042]
FX This work was supported by the National Natural Science Foundation of
   China (81673127, 81950410633, 81972992, 81903287, 81872582, 81872583) ,
   the Science and Technology Program of Guangzhou (201807010032,
   201803010054) , National Key Research and Development Program of China
   (2018YFC1004300, 2018YFE0106900) , Guangdong Provincial Natural Science
   Foundation Team Project (2018B030312005) , Fundamental Research Funds
   for the Central Universities (19ykjc01) , and Natural Science Foundation
   of Guangdong Province (2020A1515011131, 2019A050510017, 2018B05052007,
   2017A090905042) . The above funding has not taken control of the study
   design. We are grateful to all participants involving this project. The
   views expressed in this manuscript belong to the authors only.
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NR 92
TC 38
Z9 42
U1 10
U2 88
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0269-7491
EI 1873-6424
J9 ENVIRON POLLUT
JI Environ. Pollut.
PD AUG 15
PY 2021
VL 283
AR 117078
DI 10.1016/j.envpol.2021.117078
EA APR 2021
PG 10
WC Environmental Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology
GA SU4TC
UT WOS:000663131000004
PM 33839621
DA 2025-06-11
ER

PT J
AU Tanaka, M
   Okada, H
   Hashimoto, Y
   Kumagai, M
   Nishimura, H
   Fukui, M
AF Tanaka, Muhei
   Okada, Hiroshi
   Hashimoto, Yoshitaka
   Kumagai, Muneaki
   Nishimura, Hiromi
   Fukui, Michiaki
TI Combined effect of hemoglobin and mean corpuscular volume levels on
   incident metabolic syndrome: A population-based cohort study
SO CLINICAL NUTRITION ESPEN
LA English
DT Article
DE Mean corpuscular volume; Hemoglobin; Erythrocyte shrinkage and metabolic
   syndrome
ID CELL DISTRIBUTION WIDTH; HEMATOLOGICAL PARAMETERS; INSULIN-RESISTANCE;
   OXIDATIVE STRESS; COMPONENTS; MORTALITY; DISEASE; MACROCYTOSIS;
   ASSOCIATION; ERYTHROCYTE
AB Background & aims: Higher hemoglobin levels are associated with incident metabolic syndrome (MetS), and higher mean corpuscular volume (MCV) is associated with adverse outcomes. The objective of this study is to evaluate the combined effect of MCV and hemoglobin levels on incident MetS.
   Methods: In our cross-sectional study, we analyzed the prevalence of MetS in 20,162 middle-aged Japanese subjects without anemia and with normal MCV levels, as they underwent physical checkups. We subsequently analyzed incident MetS in 11,110 subjects. In order to evaluate the combined effect on incident MetS, the subjects were divided into four study groups according to cutoff values of hemoglobin and MCV for identifying the prevalence of MetS.
   Results: In the cross-sectional study, hemoglobin (adjusted odds ratio [aOR], 1.02; P < 0.0001 in men and OR, 1.04; P < 0.0001 in women, per 1.0 g/L) and MCV (aOR, 0.93; P < 0.0001 in men and OR, 0.94; P = 0.0005 in women, per 1.0 fL) were independently associated with the prevalence of MetS. In the longitudinal cohort study, hemoglobin (adjusted hazards ratio [aHR, 1.12; P = 0.0006, per 1.0 g/L) and MCV (aHR, 0.96; P < 0.0001, per 1.0 fL) were independently associated with incident MetS in men but not in women. Then, the lower hemoglobin/higher MCV group showed decreased HRs for incidence of MetS compared with other groups of men but not of women.
   Conclusions: Among the subjects without anemia and with normal MCV levels, higher hemoglobin or lower MCV levels were associated with higher prevalence of MetS in men and women. In addition, lower hemoglobin with higher MCV showed a decreased risk of MetS in men. We suggested that the assessment of hemoglobin and MCV levels could be used as practical screening tool for MetS. (C) 2020 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights reserved.
C1 [Tanaka, Muhei; Hashimoto, Yoshitaka; Fukui, Michiaki] Kyoto Prefectural Univ Med, Grad Sch Med Sci, Dept Endocrinol & Metab, Kyoto, Japan.
   [Okada, Hiroshi] Matsushita Mem Hosp, Dept Internal Med, Osaka, Japan.
   [Kumagai, Muneaki; Nishimura, Hiromi] Med Corp Soukenkai, Nishimura Clin, Kyoto, Japan.
C3 Kyoto Prefectural University of Medicine
RP Tanaka, M (corresponding author), Kyoto Prefectural Univ Med, Grad Sch Med Sci, Dept Endocrinol & Metab, Kamigyo Ku, 465 Kajii Cho, Kyoto 6028566, Japan.
EM muhei-t@koto.kpu-m.ac.ji; conti@kato.kpu-m.ac.jp;
   y-hashi@koto.kpu-m.ac.jp; kumagai@soukenkai.net;
   nsmr323@koto.kpu-m.ac.jp; michiaki@koto.kpu-m.ac.jp
RI Hashimoto, Yoshitaka/AAH-8503-2020
OI Hashimoto, Yoshitaka/0000-0002-8794-0550
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NR 37
TC 5
Z9 5
U1 0
U2 2
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2405-4577
J9 CLIN NUTR ESPEN
JI Clin. Nutr. ESPEN
PD DEC
PY 2020
VL 40
BP 314
EP 319
DI 10.1016/j.clnesp.2020.08.010
PG 6
WC Nutrition & Dietetics
WE Emerging Sources Citation Index (ESCI)
SC Nutrition & Dietetics
GA QB3YQ
UT WOS:000614078200047
PM 33183556
DA 2025-06-11
ER

PT J
AU Tabrizi, R
   Vakili, S
   Lankarani, KB
   Akbari, M
   Mirhosseini, N
   Ghayour-Mobarhan, M
   Ferns, G
   Karamali, F
   Karamali, M
   Taghizadeh, M
   Kouchaki, E
   Asemi, Z
AF Tabrizi, Reza
   Vakili, Sina
   Lankarani, Kamran B.
   Akbari, Maryam
   Mirhosseini, Naghmeh
   Ghayour-Mobarhan, Majid
   Ferns, Gordon
   Karamali, Fatemeh
   Karamali, Maryam
   Taghizadeh, Mohsen
   Kouchaki, Ebrahim
   Asemi, Zatollah
TI The Effects of Curcumin on Glycemic Control and Lipid Profiles Among
   Patients with Metabolic Syndrome and Related Disorders: A Systematic
   Review and Meta-analysis of Randomized Controlled Trials
SO CURRENT PHARMACEUTICAL DESIGN
LA English
DT Review
DE Curcumin; glycemic control; lipid profiles; meta-analysis; Randomized
   Controlled Trials (RCTs); Metabolic Syndrome (MetS)
ID TYPE-2 DIABETES-MELLITUS; FATTY LIVER-DISEASE; DOUBLE-BLIND;
   CARDIOVASCULAR-DISEASE; OXIDATIVE STRESS; BLOOD-GLUCOSE; PLACEBO;
   SUPPLEMENTATION; RISK; EXTRACT
AB Background: This systematic review and meta-analysis of randomized controlled trials (RCTs), were performed to determine the effects of curcumin intake on glycemic control and lipid profiles among patients with metabolic syndrome (MetS) and related disorders.
   Methods: We searched the following databases up until January 2018: MEDLINE, EMBASE, Web of Science, and Cochrane Central Register of Controlled Trials. The relevant data were extracted and evaluated for quality of the studies in accordance with the Cochrane risk of bias tool. Data were pooled using the inverse variance method and expressed as standardized mean difference (MDs) with 95% confidence intervals (95% CI).
   Results: Twenty-six trials with 1890 participants were included in the current meta-analysis. The findings demonstrated the significant association between curcumin intake and reduced fasting glucose levels (SMD -0.78; 95% CI, -1.20, -0.37; P<0.001), homeostasis model of assessment-estimated insulin resistance (SMD -0.91; 95% CI, -1.52, -0.31; P=0.003) and HbA1c (SMD -0.92; 95% CI, -1.37, -0.47; P<0.001). In addition, curcumin supplementation was significantly associated with triglyceride (SMD -1.21; 95 % CI, -1.78, -0.65; P<0.001) and total cholesterol reduction (SMD -0.73; 95 % CI, -1.32, -0.13; P=0.01). However, curcumin intake significantly increased insulin levels (SMD 0.92; 95% CI, 0.06, 1.78; P=0.036). We found no significant effect of curcumin supplementation on LDL-(SMD -0.52; 95% CI, -1.14, 0.11; P=0.10) and HDL-cholesterol levels (SMD 0.28; 95% CI, -0.22, 0.77; P=0.27).
   Conclusion: Overall, curcumin consumption was associated with a significant reduction in fasting glucose, HOMA-IR, HbA1c, triglycerides and total cholesterol levels among patients with MetS and related disorders, but did not affect LDL- and HDL-cholesterol levels.
C1 [Tabrizi, Reza; Akbari, Maryam] Shiraz Univ Med Sci, Inst Hlth, Ctr Hlth Policy Res, Student Res Comm, Shiraz, Iran.
   [Vakili, Sina] Shiraz Univ Med Sci, Dept Biochem, Shiraz, Iran.
   [Lankarani, Kamran B.] Shiraz Univ Med Sci, Hlth Policy Res Ctr, Shiraz, Iran.
   [Mirhosseini, Naghmeh] Pure North SEnergy Fdn, Calgary, AB, Canada.
   [Ghayour-Mobarhan, Majid] Mashhad Univ Med Sci, Sch Med, Metab Syndrome Res Ctr, Mashhad, Iran.
   [Ferns, Gordon] Brighton & Sussex Med Sch, Div Med Educ, Brighton BN1 9PH, Sussex, England.
   [Karamali, Fatemeh; Taghizadeh, Mohsen; Asemi, Zatollah] Kashan Univ Med Sci, Res Ctr Biochem & Nutr Metab Dis, Kashan, Iran.
   [Karamali, Maryam] Iran Univ Med Sci, Sch Med, Dept Gynecol & Obstet, Tehran, Iran.
   [Kouchaki, Ebrahim] Kashan Univ Med Sci, Physiol Res Ctr, Kashan, Iran.
   [Kouchaki, Ebrahim] Kashan Univ Med Sci, Sch Med, Dept Neurol, Kashan, Iran.
C3 Shiraz University of Medical Science; Shiraz University of Medical
   Science; Shiraz University of Medical Science; Mashhad University of
   Medical Sciences; University of Brighton; University of Sussex; Iran
   University of Medical Sciences
RP Asemi, Z (corresponding author), Kashan Univ Med Sci, Res Ctr Biochem & Nutr Metab Dis, Kashan, Iran.
EM asemi_r@yahoo.com
RI Akbari, Ali/G-6044-2016; Ghayour-Mobarhan, Majid/AAY-5963-2020; Vakili,
   Sina/AAW-5684-2021; Taghizadeh, Mohsen/D-7784-2017; Tabrizi,
   Reza/AAC-2486-2021; Mirhosseini, Naghmeh/AAC-7730-2019; Asemi,
   Zatollah/G-7393-2017; Lankarani, Kamran/P-5336-2019
OI Vakili, Sina/0000-0002-5472-8350; tabrizi, reza/0000-0001-7634-3948
FU Shiraz University of Medical Sciences, Shiraz, and Iran
FX The current study was founded by a grant from the Vicechancellor for
   Research, Shiraz University of Medical Sciences, Shiraz, and Iran.
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NR 45
TC 41
Z9 41
U1 1
U2 10
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1381-6128
EI 1873-4286
J9 CURR PHARM DESIGN
JI Curr. Pharm. Design
PY 2018
VL 24
IS 27
BP 3184
EP 3199
DI 10.2174/1381612824666180828162053
PG 16
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA HC5OT
UT WOS:000451853000006
PM 30156145
DA 2025-06-11
ER

PT J
AU Chien, CY
   Hung, YJ
   Shieh, YS
   Hsieh, CH
   Lu, CH
   Lin, FH
   Su, SC
   Lee, CH
AF Chien, Chu-Yen
   Hung, Yi-Jen
   Shieh, Yi-Shing
   Hsieh, Chang-Hsun
   Lu, Chieh-Hua
   Lin, Fu-Huang
   Su, Sheng-Chiang
   Lee, Chien-Hsing
TI A novel potential biomarker for metabolic syndrome in Chinese adults:
   Circulating protein disulfide isomerase family A, member 4
SO PLOS ONE
LA English
DT Article
ID ENDOPLASMIC-RETICULUM STRESS; INSULIN-RESISTANCE; APOLIPOPROTEIN-B;
   HEPATIC STEATOSIS; OBESITY; SECRETION; INFLAMMATION; ADIPONECTIN;
   CHOLESTEROL; PREVALENCE
AB Background/Objectives
   Protein disulfide isomerase (PDI) family members are specific endoplasmic reticulum proteins that are involved in the pathogenesis of numerous diseases including neurodegenerative diseases, cancer and obesity. However, the metabolic effects of PDIA4 remain unclear in humans. The aims of this study were to investigate the associations of serum PDIA4 with the metabolic syndrome (MetS) and its components in Chinese adults.
   Subjects/Methods
   A total of 669 adults (399 men and 270 women) were recruited. Serum PDIA4 concentrations and biochemical variables were recorded. Insulin sensitivity and beta-cell function were examined by homeostasis model assessment. MetS was defined based on the modified National Cholesterol Education Program Adult Treatment Panel III criteria for Asia Pacific.
   Results
   The participants with MetS had significantly higher serum PDIA4 levels than those without MetS (P<0.001). After adjustments, the individuals with the highest PDIA4 tertile were associated with a higher risk of MetS than those with the lowest tertile (OR = 4.83, 95% CI: 2.71-8.60). The concentration of PDIA4 showed a stepwise increase with the components of MetS (P<0.001 for trend). The individuals with the highest PDIA4 tertile were significantly associated with waist circumference (OR = 2.41, 95% CI 1.34-4.32), blood pressure (OR = 2.71, 95% CI 1.57-4.67), fasting glucose concentration (OR = 3.17, 95% CI 1.80-5.57), and serum triglycerides (OR = 4.12, 95% CI 2.30-7.37) than those with the lowest tertile. At cutoff point of 15.24 ng/ml, the diagnostic sensitivity and specificity of PDIA4 for the metabolic syndrome were 67 and 72%, respectively, in male patients and 60 and 78%, respectively, in female patients. Finally, the result showed that PDIA4 had a significantly higher area under the curve compared with blood pressure to detect MetS using receiver operating characteristic analysis.
   Conclusions
   Serum PDIA4 concentrations are closely associated to MetS and its components in Chinese adults.
C1 [Chien, Chu-Yen; Su, Sheng-Chiang; Lee, Chien-Hsing] Natl Def Med Ctr, Grad Inst Med Sci, Taipei, Taiwan.
   [Hung, Yi-Jen; Hsieh, Chang-Hsun; Lu, Chieh-Hua; Su, Sheng-Chiang; Lee, Chien-Hsing] Natl Def Med Ctr, Tri Serv Gen Hosp, Div Endocrinol & Metab, Taipei, Taiwan.
   [Shieh, Yi-Shing] Natl Def Med Ctr, Sch Dent, Taipei, Taiwan.
   [Shieh, Yi-Shing] Tri Serv Gen Hosp, Dept Oral Diag & Pathol, Taipei, Taiwan.
   [Lin, Fu-Huang] Natl Def Med Ctr, Sch Publ Hlth, Taipei, Taiwan.
C3 National Defense Medical Center; National Defense Medical Center;
   Tri-Service General Hospital; National Defense Medical Center;
   Tri-Service General Hospital; National Defense Medical Center
RP Lee, CH (corresponding author), Natl Def Med Ctr, Grad Inst Med Sci, Taipei, Taiwan.; Lee, CH (corresponding author), Natl Def Med Ctr, Tri Serv Gen Hosp, Div Endocrinol & Metab, Taipei, Taiwan.
EM doc10383@gmail.com
RI Li, Tsai-Chung/P-2052-2015
FU National Science Council [MOST 104-2314-B-016-026, MOST
   104-2314-B-016-053, MOST 105-2314-B-016-040-MY3, MOST
   105-2314-B-016-030-MY2]; National Defense Medical Center [MAB-104-82];
   Tri-Service General Hospital, Taiwan [TSGH-C105-005-503,
   TSGH-C105-005-S04, TSGH-C106-006-S01, TSGH-C106-006-S02,
   TSGH-C106-007-S01, TSGH-C105-120, TSGH-C105-183, TSGH-C105-184,
   TSGH-C105-185]
FX This work was supported by research grants from the National Science
   Council (MOST 104-2314-B-016-026, MOST 104-2314-B-016-053, MOST
   105-2314-B-016-040-MY3, MOST 105-2314-B-016-030-MY2), National Defense
   Medical Center (MAB-104-82), and Tri-Service General Hospital
   (TSGH-C105-005-503, TSGH-C105-005-S04, TSGH-C106-006-S01,
   TSGH-C106-006-S02, TSGH-C106-007-S01, TSGH-C105-120, TSGH-C105-183,
   TSGH-C105-184, TSGH-C105-185), Taiwan. The funders had no role in study
   design, data collection and analysis, decision to publish, or
   preparation of the manuscript.This work was supported by research grants
   from the National Science Council (MOST 104-2314-B-016-026, MOST
   104-2314-B-016-053, MOST 105-2314-B-016-040-MY3, MOST
   105-2314-B-016-030-MY2), National Defense Medical Center (MAB-104-82),
   and Tri-Service General Hospital (TSGH-C105-005-503, TSGH-C105-005-504,
   TSGH-C106-006-501, TSGH-C106-006-502, TSGH-C106-007-501, TSGH-C105-120,
   TSGH-C105-183, TSGH-C105-184, TSGH-C105-185), Taiwan.
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NR 49
TC 13
Z9 14
U1 1
U2 3
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JUN 26
PY 2017
VL 12
IS 6
AR e0179963
DI 10.1371/journal.pone.0179963
PG 13
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA EZ2KD
UT WOS:000404537300033
PM 28650993
OA Green Submitted, gold, Green Published
DA 2025-06-11
ER

PT J
AU Albert, U
   Aguglia, A
   Chiarle, A
   Bogetto, F
   Maina, G
AF Albert, Umberto
   Aguglia, Andrea
   Chiarle, Alice
   Bogetto, Filippo
   Maina, Giuseppe
TI Metabolic syndrome and obsessive-compulsive disorder: a naturalistic
   Italian study
SO GENERAL HOSPITAL PSYCHIATRY
LA English
DT Article
DE Obsessive-compulsive disorder; Metabolic syndrome; Antipsychotic;
   Obesity; Weight gain
ID QUALITY-OF-LIFE; POSTTRAUMATIC-STRESS-DISORDER; CARDIOVASCULAR-DISEASE;
   INSULIN-RESISTANCE; BIPOLAR DISORDER; FAT OXIDATION; SINGLE-BLIND;
   PREVALENCE; RISK; SMOKING
AB Objective: The increased risk for metabolic syndrome (MetS) in individuals with schizophrenia and bipolar disorder has been documented. No study examined MetS in patients with obsessive-compulsive disorder (OCD), despite the fact that a great proportion of them are treated with antipsychotic addition. The aim of our study was to investigate the prevalence and the sociodemographic and clinical correlates of MetS in an Italian sample of patients with OCD.
   Method: Subjects with Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision, OCD and a Yale-Brown Obsessive-Compulsive Scale score >= 16 were included. Sociodemographic and clinical characteristics, current and lifetime pharmacological treatments, lifestyle information, and comorbidity for cardiovascular diseases and diabetes were collected. MetS was diagnosed according to the National Cholesterol Education Program Adult Treatment Panel III modified criteria.
   Results: We enrolled 104 patients with OCD. MetS was present in 21.2% (95% confidence interval: 13.7%-30.3%) of the sample. Abdominal obesity was present in 36.5%, hypertension in 42.3%, high triglycerides in 23.1%, low high-density lipoprotein cholesterol levels in 22.1% and fasting hyperglycemia in 4.8% of the sample. MetS was associated with cigarette smoking (duration of cigarette smoking), absence of physical activity, a higher body mass index and a greater proportion of obesity. Among pharmacological treatments, MetS was associated with the duration of the exposure (lifetime) to antipsychotics.
   Conclusions: This is the first study that examined the prevalence and correlates of MetS in a sample of patients with OCD. Our cross-sectional evaluation found a prevalence of MetS higher than those reported in the Italian general population, although the confidence interval encompasses the general population estimate reported. Patients with OCD on antipsychotic treatment are particularly at risk for MetS and should be carefully monitored for metabolic abnormalities and cardiovascular complications. (C) 2013 Elsevier Inc. All rights reserved.
C1 [Albert, Umberto; Aguglia, Andrea; Chiarle, Alice; Bogetto, Filippo; Maina, Giuseppe] Univ Turin, Dept Neurosci, Anxiety & Mood Disorders Unit, I-10126 Turin, Italy.
C3 University of Turin
RP Albert, U (corresponding author), Univ Turin, Dept Neurosci, Anxiety & Mood Disorders Unit, Via Cherasco 11, I-10126 Turin, Italy.
EM umberto.albert@unito.it
RI Maina, Giuseppe/AAC-7158-2022
OI Aguglia, Andrea/0000-0002-2003-2101; Albert,
   Umberto/0000-0001-9781-4219; Maina, Giuseppe/0000-0002-2533-140X
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NR 75
TC 54
Z9 58
U1 0
U2 13
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0163-8343
EI 1873-7714
J9 GEN HOSP PSYCHIAT
JI Gen. Hosp. Psych.
PD MAR-APR
PY 2013
VL 35
IS 2
BP 154
EP 159
DI 10.1016/j.genhosppsych.2012.10.004
PG 6
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 098FS
UT WOS:000315533300009
PM 23158675
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Bullon, P
   Cordero, MD
   Quiles, JL
   Morillo, JM
   Ramirez-Tortosa, MD
   Battino, M
AF Bullon, Pedro
   David Cordero, Mario
   Luis Quiles, Jose
   Manuel Morillo, Juan
   del Carmen Ramirez-Tortosa, Maria
   Battino, Maurizio
TI Mitochondrial dysfunction promoted by Porphyromonas gingivalis
   lipopolysaccharide as a possible link between cardiovascular disease and
   periodontitis
SO FREE RADICAL BIOLOGY AND MEDICINE
LA English
DT Article
DE Periodontitis; CoQ(10); Mitochondrial membrane potential; Apoptosis;
   Reactive oxygen species; Cardiovascular disease; Free radicals
ID PAPILLON-LEFEVRE-SYNDROME; OXIDATIVE STRESS; COQ(10) DEFICIENCY;
   METABOLIC SYNDROME; ATHEROSCLEROSIS; INFLAMMATION; SUPEROXIDE; PATTERNS;
   CORONARY; PLASMA
AB Oxidative stress is one of the factors that could explain the pathophysiological mechanism of inflammatory conditions that occur in cardiovascular disease (CVD) and periodontitis. Such inflammatory response is often evoked by specific bacteria, as the lipopolysaccharide (LPS) of Porphyromonas gingivalis is a key factor in this process. The aim of this research was to study the role of mitochondrial dysfunction in peripheral blood mononuclear cells (PBMCs) from periodontitis patients and to evaluate the influence of LPS on fibroblasts to better understand the pathophysiology of periodontitis and its relationship with CVD. PBMCs from patients showed lower CoQ(10) levels and citrate synthase activity, together with high levels of ROS production. LPS-treated fibroblasts provoked increased oxidative stress and mitochondrial dysfunction by a decrease in mitochondrial protein expression, mitochondrial mass, and mitochondrial membrane potential. Our study supports the hypothesis that LPS-mediated mitochondrial dysfunction could be at the origin of oxidative stress in periodontal patients. Abnormal PBMC performance may promote oxidative stress and alter cytokine homeostasis. In conclusion, mitochondrial dysfunction could represent a possible link to understanding the interrelationships between two prominent inflammatory diseases: periodontitis and CVD. (C) 2011 Elsevier Inc. All rights reserved.
C1 [Battino, Maurizio] Univ Politecn Marche, Dept Biochem Biol & Genet, Fac Med, I-60100 Ancona, Italy.
   [Bullon, Pedro; Manuel Morillo, Juan] Univ Seville, Dept Periodontol, Sch Dent, Seville, Spain.
   [David Cordero, Mario] Univ Pablo Olavide CSIC, Ctr Andaluz Biol Desarrollo, Seville 41013, Spain.
   [David Cordero, Mario] ISCIII, Ctr Invest Biomed Red Enfermedades Raras, Seville 41013, Spain.
   [Luis Quiles, Jose] Univ Granada, Dept Physiol, Inst Nutr & Food Technol Jose Mataix, Biomed Res Ctr, Granada, Spain.
   [del Carmen Ramirez-Tortosa, Maria] Univ Granada, Dept Biochem & Mol Biol 2, Inst Nutr & Food Technol Jose Mataix, Biomed Res Ctr, Granada, Spain.
C3 Marche Polytechnic University; University of Sevilla; Consejo Superior
   de Investigaciones Cientificas (CSIC); Universidad Pablo de Olavide;
   CSIC - Andalusian Center for Developmental Biology (CABD); CIBER -
   Centro de Investigacion Biomedica en Red; CIBERER; Instituto de Salud
   Carlos III; University of Granada; University of Granada
RP Battino, M (corresponding author), Univ Politecn Marche, Dept Biochem Biol & Genet, Fac Med, I-60100 Ancona, Italy.
EM m.a.battino@univpm.it
RI Cordero, Mario D./L-8006-2014; Battino, Maurizio/E-6103-2012; Bullon,
   Pedro/E-6319-2010; Quiles, Jose L./C-6911-2013
OI Cordero, Mario D./0000-0003-0151-3644; Battino,
   Maurizio/0000-0002-7250-1782; Bullon, Pedro/0000-0003-4873-4196; Quiles,
   Jose L./0000-0002-9048-9086
CR [Anonymous], WHO WARNS RIS THREAT
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NR 41
TC 93
Z9 98
U1 0
U2 35
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0891-5849
EI 1873-4596
J9 FREE RADICAL BIO MED
JI Free Radic. Biol. Med.
PD MAY 15
PY 2011
VL 50
IS 10
BP 1336
EP 1343
DI 10.1016/j.freeradbiomed.2011.02.018
PG 8
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 765HA
UT WOS:000290694900015
PM 21354301
OA Green Published
DA 2025-06-11
ER

PT J
AU Vargas-Robles, H
   Rios, A
   Arellano-Mendoza, M
   Escalante, BA
   Schnoor, M
AF Vargas-Robles, Hilda
   Rios, Amelia
   Arellano-Mendoza, Monica
   Escalante, Bruno A.
   Schnoor, Michael
TI Antioxidative Diet Supplementation Reverses High-Fat Diet-Induced
   Increases of Cardiovascular Risk Factors in Mice
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Article
ID CHRONIC L-ARGININE; METABOLIC SYNDROME; OXIDATIVE STRESS; VITAMIN-E;
   TOCOPHEROL SUPPLEMENTATION; ENDOTHELIAL DYSFUNCTION; ALPHA-TOCOPHEROL;
   OBESITY; INFLAMMATION; ATHEROSCLEROSIS
AB Obesity is a worldwide epidemic that is characterized not only by excessive fat deposition but also by systemic microinflammation, high oxidative stress, and increased cardiovascular risk factors. While diets enriched in natural antioxidants showed beneficial effects on oxidative stress, blood pressure, and serum lipid composition, diet supplementation with synthetic antioxidants showed contradictive results. Thus, we tested in C57Bl/6 mice whether a daily dosage of an antioxidative mixture consisting of vitamin C, vitamin E, L-arginine, eicosapentaenoic acid, and docosahexaenoic acid (corabion) would affect cardiovascular risk factors associated with obesity. Obese mice showed increased serum triglyceride and glucose levels and hypertension after eight weeks of being fed a high-fat diet (HFD). Importantly, corabion ameliorated all of these symptoms significantly. Oxidative stress and early signs of systemic microinflammation already developed after two weeks of high-fat diet and were significantly reduced by daily doses of corabion. Of note, the beneficial effects of corabion could not be observed when applying its single antioxidative components suggesting that a combination of various nutrients is required to counteract HFD-induced cardiovascular risk factors. Thus, daily consumption of corabion may be beneficial for the management of obesity-related cardiovascular complications.
C1 [Vargas-Robles, Hilda; Schnoor, Michael] IPN, Ctr Res & Adv Studies CINVESTAV, Dept Mol Biomed, Mexico City 07360, DF, Mexico.
   [Rios, Amelia; Escalante, Bruno A.] CINVESTAV IPN Monterrey, Apodaca 66600, NL, Mexico.
   [Arellano-Mendoza, Monica] IPN, Super Med Sch, Postgrad & Res Sect, Mexico City 11340, DF, Mexico.
C3 Instituto Politecnico Nacional - Mexico; CINVESTAV - Centro de
   Investigacion y de Estudios Avanzados del Instituto Politecnico
   Nacional; Instituto Politecnico Nacional - Mexico
RP Schnoor, M (corresponding author), IPN, Ctr Res & Adv Studies CINVESTAV, Dept Mol Biomed, Mexico City 07360, DF, Mexico.
EM mschnoor@cinvestav.mx
RI Rios, Antonio/L-3870-2017; Schnoor, Michael/H-1863-2016
OI Schnoor, Michael/0000-0002-0269-5884; Rios, Amelia/0000-0002-5328-118X
FU Mexican Council for Science and Technology (CONACyT) [42999-A-1, 179895]
FX This work was supported by grants of the Mexican Council for Science and
   Technology (CONACyT, 42999-A-1 to BAE and 179895 to MS).
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NR 38
TC 35
Z9 39
U1 0
U2 13
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PY 2015
VL 2015
AR 467471
DI 10.1155/2015/467471
PG 9
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA CH1NO
UT WOS:000353788700001
PM 25922641
OA Green Published, Green Submitted, hybrid
DA 2025-06-11
ER

PT J
AU Winnay, JN
   Boucher, J
   Mori, MA
   Ueki, K
   Kahn, CR
AF Winnay, Jonathon N.
   Boucher, Jeremie
   Mori, Marcelo A.
   Ueki, Kohjiro
   Kahn, C. Ronald
TI A regulatory subunit of phosphoinositide 3-kinase increases the nuclear
   accumulation of X-box-binding protein-1 to modulate the unfolded protein
   response
SO NATURE MEDICINE
LA English
DT Article
ID ENDOPLASMIC-RETICULUM STRESS; INSULIN-RESISTANCE; PHOSPHATIDYLINOSITOL
   3-KINASE; ER STRESS; SKELETAL-MUSCLE; MESSENGER-RNA; PURIFICATION
   METHOD; METABOLIC SYNDROME; P85-ALPHA SUBUNIT; ADIPOSE-TISSUE
AB Class Ia phosphoinositide 3-kinase (PI3K), an essential mediator of the metabolic actions of insulin, is composed of a catalytic (p110 alpha or p110 beta) and regulatory (p85 alpha, p85 beta or p55 gamma) subunit. Here we show that p85 alpha interacts with X-box-binding protein-1 (XBP-1), a transcriptional mediator of the unfolded protein response (UPR), in an endoplasmic reticulum (ER) stress-dependent manner. Cell lines with knockout or knockdown of p85 alpha show marked alterations in the UPR, including reduced ER stress-dependent accumulation of nuclear XBP-1, decreased induction of UPR target genes and increased rates of apoptosis. This is associated with a decreased activation of inositol-requiring protein-1 alpha (IRE1 alpha) and activating transcription factor-6 alpha (ATF6 alpha). Mice with deletion of p85 alpha in liver (L-Pik3r1(-/-)) show a similar attenuated UPR after tunicamycin administration, leading to an increased inflammatory response. Thus, p85 alpha forms a previously unrecognized link between the PI3K pathway, which is central to insulin action, and the regulation of the cellular response to ER stress, a state that when unresolved leads to insulin resistance.
C1 [Winnay, Jonathon N.; Boucher, Jeremie; Mori, Marcelo A.; Kahn, C. Ronald] Harvard Univ, Sch Med, Joslin Diabet Ctr, Sect Integrat Physiol & Metab,Res Div, Boston, MA 02115 USA.
   [Ueki, Kohjiro] Univ Tokyo, Dept Metab Dis, Grad Sch Med, Tokyo, Japan.
C3 Harvard University; Harvard University Medical Affiliates; Joslin
   Diabetes Center, Inc.; Harvard Medical School; University of Tokyo
RP Kahn, CR (corresponding author), Harvard Univ, Sch Med, Joslin Diabet Ctr, Sect Integrat Physiol & Metab,Res Div, Boston, MA 02115 USA.
EM c.ronald.kahn@joslin.harvard.edu
RI Kahn, Ronald/AAY-2435-2021; Ueki, Kohjiro/MGU-5108-2025; Boucher,
   Jeremie/G-6602-2015; Mori, Marcelo/R-2881-2018
OI Mori, Marcelo/0000-0001-7112-5263
FU US National Institutes of Health [DK55545, DK07260-30]; Joslin Diabetes
   and Endocrine Research Center [DK36836]
FX We would like to thank D. Ron (New York University School of Medicine)
   for providing the Flag-XBP-1u and Flag-XBP-1s expression plasmids. This
   work was supported by US National Institutes of Health grant DK55545 and
   National Institutes of Health training grant DK07260-30, as well as Core
   laboratory support from the Joslin Diabetes and Endocrine Research
   Center grant DK36836. We would also like to thank U. Ozcan for useful
   advice and discussion and S. Green and S. Flaherty for assistance in
   preparation of this manuscript.
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NR 57
TC 162
Z9 188
U1 2
U2 17
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 1078-8956
EI 1546-170X
J9 NAT MED
JI Nat. Med.
PD APR
PY 2010
VL 16
IS 4
BP 438
EP U120
DI 10.1038/nm.2121
PG 9
WC Biochemistry & Molecular Biology; Cell Biology; Medicine, Research &
   Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology; Research & Experimental
   Medicine
GA 580KJ
UT WOS:000276446800048
PM 20348923
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Rousseau, M
   Horne, J
   Guénard, F
   De Toro-Martín, J
   Garneau, V
   Guay, V
   Kearney, M
   Pilon, G
   Roy, D
   Couture, P
   Couillard, C
   Marette, A
   Vohl, MC
AF Rousseau, Michele
   Horne, Justine
   Guenard, Frederic
   De Toro-Martin, Juan
   Garneau, Veronique
   Guay, Valerie
   Kearney, Michele
   Pilon, Genevieve
   Roy, Denis
   Couture, Patrick
   Couillard, Charles
   Marette, Andre
   Vohl, Marie-Claude
TI An 8-week freeze-dried blueberry supplement impacts immune-related
   pathways: a randomized, double-blind placebo-controlled trial
SO GENES AND NUTRITION
LA English
DT Article
DE Metabolic syndrome; Blueberry; Overweight; obesity; Nutrition; Immunity;
   Transcriptomics; Metabolomics; Gene expression
ID METABOLIC SYNDROME; INSULIN-RESISTANCE; BLOOD-PRESSURE; ANTIOXIDANT
   ACTIVITY; ARTERIAL STIFFNESS; GLUCOSE-TOLERANCE; OXIDATIVE STRESS;
   UNITED-STATES; OBESE; CONSUMPTION
AB Background: Blueberries contain high levels of polyphenolic compounds with high in vitro antioxidant capacities. Their consumption has been associated with improved vascular and metabolic health.
   Purpose: The objective was to examine the effects of blueberry supplement consumption on metabolic syndrome (MetS) parameters and potential underlying mechanisms of action.
   Methods: A randomized double-blind placebo-controlled intervention trial was conducted in adults at risk of developing MetS. Participants consumed 50 g daily of either a freeze-dried highbush blueberry powder (BBP) or a placebo powder for 8 weeks (n = 49). MetS phenotypes were assessed at weeks 0, 4 and 8. Fasting blood gene expression profiles and plasma metabolomic profiles were examined at baseline and week 8 to assess metabolic changes occurring in response to the BBP. A per-protocol analysis was used.
   Results: A significant treatment effect was observed for plasma triglyceride levels that was no longer significant after further adjustments for age, sex, BMI and baseline values. In addition, the treatment*time interactions were non-significant therefore suggesting that compared with the placebo, BBP had no statistically significant effect on body weight, blood pressure, fasting plasma lipid, insulin and glucose levels, insulin resistance (or sensitivity) or glycated hemoglobin concentrations. There were significant changes in the expression of 49 genes and in the abundance of 35 metabolites following BBP consumption. Differentially regulated genes were clustered in immune-related pathways.
   Conclusion: An 8-week BBP intervention did not significantly improve traditional markers of cardiometabolic health in adults at risk of developing MetS. However, changes in gene expression and metabolite abundance suggest that clinically significant cardiometabolic changes could take longer than 8 weeks to present and/or could result from whole blueberry consumption or a higher dosage. BBP may also have an effect on factors such as immunity even within a shorter 8-week timeframe.
C1 [Rousseau, Michele; Horne, Justine; Guenard, Frederic; De Toro-Martin, Juan; Garneau, Veronique; Guay, Valerie; Kearney, Michele; Pilon, Genevieve; Roy, Denis; Couture, Patrick; Couillard, Charles; Marette, Andre; Vohl, Marie-Claude] Univ Laval, Inst Nutr & Aliments Fonct INAF, Ctr Nutr Sante & Soc NUTRISS, Quebec City, PQ G1V 0A6, Canada.
   [Rousseau, Michele; Horne, Justine; Garneau, Veronique; Couillard, Charles; Vohl, Marie-Claude] Univ Laval, Sch Nutr, Quebec City, PQ G1V 0A6, Canada.
   [Pilon, Genevieve; Marette, Andre] Quebec Heart & Lung Inst IUCPQ Res Ctr, 2725 Chemin St Foy, Quebec City, PQ G1V 4G5, Canada.
C3 Laval University; Laval University
RP Vohl, MC (corresponding author), Univ Laval, Inst Nutr & Aliments Fonct INAF, Ctr Nutr Sante & Soc NUTRISS, Quebec City, PQ G1V 0A6, Canada.; Vohl, MC (corresponding author), Univ Laval, Sch Nutr, Quebec City, PQ G1V 0A6, Canada.
EM marie.claude.vohl@fsaa.ulaval.ca
RI Vohl, Marie-Claude/AAQ-1378-2021; Marette, Andre/E-9342-2013; Roy,
   Denis/H-4998-2011
OI Keathley, Justine/0000-0002-9176-9645
FU US Highbush Blueberry Council (USHBC); INITIA Foundation; Canadian
   Institutes of Health Research, Centre Nutrition, sante et societe
   (NUTRISS); Institut sur la nutrition et les aliments fonctionnels (INAF)
FX This work was supported by the US Highbush Blueberry Council (USHBC).
   The funders were not involved in the study design, data analysis, or
   interpretation of results. Marie-Claude Vohl is a Canada Research Chair
   in Genomics Applied to Nutrition and Metabolic Health. Andre Marette is
   holding a Pfizer research Chair in the pathogenesis of insulin
   resistance and cardiovascular diseases. Michele Rousseau received a
   studentship from the INITIA Foundation. Justine Horne was supported
   through postdoctoral fellowships from the Canadian Institutes of Health
   Research, Centre Nutrition, sante et societe (NUTRISS) and the Institut
   sur la nutrition et les aliments fonctionnels (INAF).
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NR 79
TC 13
Z9 13
U1 0
U2 41
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1555-8932
EI 1865-3499
J9 GENES NUTR
JI Genes Nutr.
PD DEC
PY 2021
VL 16
IS 1
AR 7
DI 10.1186/s12263-021-00688-2
PG 19
WC Genetics & Heredity; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Genetics & Heredity; Nutrition & Dietetics
GA SD5YS
UT WOS:000651453000001
PM 34000994
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Chang, JH
   Huang, PT
   Lin, YK
   Lin, CE
   Lin, CM
   Shieh, YH
   Lin, YC
AF Chang, Jen-Hung
   Huang, Pai-Tsang
   Lin, Yen-Kuang
   Lin, Ching-En
   Lin, Chien-Min
   Shieh, Ying-Hua
   Lin, Ying-Chin
TI ASSOCIATION BETWEEN SLEEP DURATION AND SLEEP QUALITY, AND METABOLIC
   SYNDROME IN TAIWANESE POLICE OFFICERS
SO INTERNATIONAL JOURNAL OF OCCUPATIONAL MEDICINE AND ENVIRONMENTAL HEALTH
LA English
DT Article
DE Metabolic syndrome; Sleep duration; Sleep quality; Police officer
ID CARDIOVASCULAR-DISEASE MORBIDITY; LAW-ENFORCEMENT OFFICERS; MIDDLE-AGED
   MEN; WEIGHT-GAIN; SHIFT WORK; RISK; POPULATION; HEALTH; STRESS;
   INFLAMMATION
AB Objectives: This study's objective was to examine association between sleep duration and sleep quality, and metabolic syndrome (MetS) and its components in Taiwanese male police officers. Material and Methods: Male police officers who underwent annual health examinations were invited to join the study and eventually a total of 796 subjects was included in it. The study subjects were divided into 5 groups according to the length (duration) of sleep: < 5, 5-5.9, 6-6.9, 7-7.9 and >= 8 h per day, and the global Pittsburgh Sleep Quality Index was used to categorize their sleep quality as good or poor. To analyze the association between sleep problems and MetS, adjusted odds ratio and respective 95% confidence intervals (CI) were computed. Results: The prevalence of MetS in Taiwanese male police officers was 24.5%. Abdominal obesity had the highest proportion (36.2%) among 5 components of MetS. More than 1/2 of the police officers (52.3%) had poor sleep quality. Police officers with higher scores of sleep disturbances had a higher prevalence of MetS (p = 0.029) and abdominal obesity ( p = 0.009). After adjusting for age, low-density lipoprotein cholesterol, smoking status, alcohol drinking habit, physical habitual exercise, snoring and type of shift work, the police officers who slept less than 5 h were 88% more likely to suffer from abdominal obesity than those who slept 7-7.9 h (95% CI: 1.01-3.5). Sleep quality was not associated with MetS and its components. Conclusions: The police officers who slept less than 5 h were more likely to experience abdominal obesity in Taiwan, and those with higher scores of sleep disturbances had a higher prevalence of MetS and abdominal obesity. It is recommended that police officers with short sleep duration or sleep disturbances be screened for MetS and waist circumference in order to prevent cardiovascular diseases.
C1 [Chang, Jen-Hung; Lin, Ching-En; Shieh, Ying-Hua] Taipei Med Univ, Wan Fang Hosp, Dept Family Med, Taipei 11696, Taiwan.
   [Chang, Jen-Hung; Shieh, Ying-Hua; Lin, Ying-Chin] Taipei Med Univ, Coll Med, Sch Med, Dept Family Med, Taipei 11696, Taiwan.
   [Huang, Pai-Tsang] Taipei Med Univ, Wan Fang Hosp, Dept Occupat Med, Taipei 11696, Taiwan.
   [Lin, Yen-Kuang] Taipei Med Univ, Grad Inst Nursing, Taipei 11696, Taiwan.
   [Lin, Chien-Min] Taipei Med Univ, Shuang Ho Hosp, Dept Neurosurg, Taipei 11696, Taiwan.
   [Lin, Chien-Min] Taipei Med Univ, Coll Med, Dept Neurosurg, Sch Med, Taipei 11696, Taiwan.
   [Lin, Ying-Chin] Taipei Med Univ, Dept Family Med, Shuang Ho Hosp, Taipei 11696, Taiwan.
   [Lin, Ying-Chin] Taipei Med Univ, Hlth Management Ctr, Wan Fang Hosp, Taipei 11696, Taiwan.
C3 Taipei Municipal WanFang Hospital; Taipei Medical University; Taipei
   Medical University; Taipei Municipal WanFang Hospital; Taipei Medical
   University; Taipei Medical University; Taipei Medical University; Shuang
   Ho Hospital; Taipei Medical University; Taipei Medical University;
   Shuang Ho Hospital; Taipei Medical University; Taipei Municipal WanFang
   Hospital
RP Lin, YC (corresponding author), Taipei Med Univ, Wan Fang Hosp, Hlth Management Ctr, 111,Sec 3,Xinglong Rd, Taipei 11696, Taiwan.
EM 100565@w.tmu.edu.tw
FU Wan Fang Hospital, Taipei Medical University, Taiwan [102-wf-eva-08]
FX This study was financially supported by a grant titled "The study of
   relationship of sleep quality and metabolic syndrome among the police
   officers with obesity and overweight" (program No. 102-wf-eva-08) from
   Wan Fang Hospital, Taipei Medical University, Taiwan. Grant manager:
   Fei-Peng Lee, M.D.
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NR 47
TC 43
Z9 49
U1 0
U2 12
PU NOFER INST OCCUPATIONAL MEDICINE, POLAND
PI LODZ
PA SW TERESY 8, LODZ, 91-348, POLAND
SN 1232-1087
EI 1896-494X
J9 INT J OCCUP MED ENV
JI Int. J. Occup. Med. Environ. Health
PY 2015
VL 28
IS 6
BP 1011
EP 1023
DI 10.13075/ijomeh.1896.00359
PG 13
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA CU1KQ
UT WOS:000363280700007
PM 26294202
OA gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Pennathur, S
   Heinecke, JW
AF Pennathur, Subramaniam
   Heinecke, Jay W.
TI Mechanisms for oxidative stress in diabetic cardiovascular disease
SO ANTIOXIDANTS & REDOX SIGNALING
LA English
DT Review
ID LOW-DENSITY-LIPOPROTEIN; ALPHA-LIPOIC ACID; MASS-SPECTROMETRIC
   QUANTIFICATION; CORONARY-HEART-DISEASE; MYELOPEROXIDASE-CATALYZED
   OXIDATION; MAILLARD REACTION-PRODUCTS; GLYCATION END-PRODUCT; OXIDIZED
   AMINO-ACIDS; SMOOTH-MUSCLE-CELLS; LIPID-PEROXIDATION
AB Obesity, metabolic syndrome, and diabetes are increasingly prevalent in Western society, and they markedly increase the risk for atherosclerotic vascular disease, the major cause of death in diabetics. Although recent evidence suggests a causal role for oxidative stress in insulin resistance, diabetes, and atherosclerosis, there is considerable controversy regarding its nature, magnitude, and underlying mechanisms. Glucose promotes glycoxidation reactions in vitro, and products of glycoxidation and lipoxidation are elevated in plasma and tissue from humans suffering from diabetes, but the exact relationships between hyperglycemia and oxidative stress are poorly understood. This review focuses on molecular mechanisms of increased oxidative stress in diabetes, the relationship of oxidant production to hyperglycemia, and the potential interaction of reactive carbonyls and lipids in oxidant generation. Using highly sensitive and specific gas chromatography-mass spectrometry, molecular signatures of specific oxidation pathways were identified in tissues of diabetic humans and animals. These studies support the hypothesis that unique reactive intermediates generated in localized microenvironments of vulnerable tissues promote diabetic damage. Therapies interrupting these reactive pathways in vascular tissue might help prevent cardiovascular disease in this high-risk population.
C1 Univ Michigan, Dept Med, Ann Arbor, MI 48109 USA.
   Univ Washington, Dept Med, Seattle, WA 98195 USA.
C3 University of Michigan System; University of Michigan; University of
   Washington; University of Washington Seattle
RP Pennathur, S (corresponding author), Univ Michigan, Dept Med, Ann Arbor, MI 48109 USA.
EM spennath@umich.edu
RI Pennathur, Subramaniam/O-7032-2017
OI Pennathur, Subramaniam/0000-0003-3628-6883
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NR 154
TC 133
Z9 186
U1 0
U2 10
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1523-0864
EI 1557-7716
J9 ANTIOXID REDOX SIGN
JI Antioxid. Redox Signal.
PD JUL
PY 2007
VL 9
IS 7
BP 955
EP 969
DI 10.1089/ars.2007.1595
PG 15
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 170EW
UT WOS:000246646200014
PM 17508917
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Duc, HN
   Oh, H
   Kim, MS
AF Duc, Hai Nguyen
   Oh, Hojin
   Kim, Min-Sun
TI Effects of Antioxidant Vitamins, Curry Consumption, and Heavy Metal
   Levels on Metabolic Syndrome with Comorbidities: A Korean
   Community-Based Cross-Sectional Study
SO ANTIOXIDANTS
LA English
DT Article
DE antioxidant vitamins; heavy metals; curry consumption; metabolic
   syndrome; comorbidities
ID EXAMINATION SURVEY KNHANES; TYPE-2 DIABETES-MELLITUS; OXIDATIVE STRESS;
   NATIONAL-HEALTH; INSULIN-RESISTANCE; ENDOTHELIAL-CELLS; THIAMINE;
   GLUCOSE; ASSOCIATION; PREVENTION
AB The burden of metabolic syndrome (MetS) has increased worldwide, especially during the COVID-19 pandemic, and this phenomenon is related to environmental, dietary, and lifestyle risk factors. We aimed to determine the association between the levels of serum heavy metals, hs-CRP, vitamins, and curry intake and to predict risks of MetS based on marginal effects. A data set of 60,256 Koreans aged >= 15 years between 2009 and 2017 was used to obtain information on sociodemographic, lifestyle, family history characteristics, MetS, food intake survey, and serum heavy metals. Daily intake of vitamins was measured by a one-day 24 h recall, and curry consumption was calculated using a food frequency questionnaire. Serum heavy metal levels were quantified by graphite furnace atomic absorption spectrometry and using a mercury analyzer. We found that vitamin B1, B2, B3, C, and A intakes were significantly lower in subjects with than without MetS. In contrast, serum levels of Pb, Hg, Cd, vitamin A, E, and hs-CRP were significantly higher in subjects with MetS. The risk of MetS was significantly lower for high curry consumers than low curry consumers (adjusted odds ratio 0.85, 95%CI 0.74-0.98). The risks of MetS were reduced by 12% and 1%, when vitamin B1 and C intakes increased by one mg, respectively, but were increased by 14%, 3%, and 9%, when serum levels of Pb, Hg, and hs-CRP increased by one unit. These results show that the potential health benefits resulting from vitamin and curry intakes could protect the public against the dual burden of communicable and non-communicable diseases. Further studies are required to reduce risk factors associated with serum heavy metal levels and to determine whether interactions between vitamin and curry consumption influence the presence of MetS.
C1 [Duc, Hai Nguyen; Oh, Hojin; Kim, Min-Sun] Sunchon Natl Univ, Dept Pharm, Coll Pharm, Sunchon 57922, South Korea.
   [Duc, Hai Nguyen; Oh, Hojin; Kim, Min-Sun] Sunchon Natl Univ, Res Inst Life & Pharmaceut Sci, Sunchon 57922, South Korea.
C3 Sunchon National University; Sunchon National University
RP Kim, MS (corresponding author), Sunchon Natl Univ, Dept Pharm, Coll Pharm, Sunchon 57922, South Korea.
EM haiyds@gmail.com; navytoto@hanmail.net; minsun@scnu.ac.kr
RI Oh, Hojin/ABA-7781-2021; Nguyen Duc, Hai/AAD-8210-2020
OI Oh, Hojin/0000-0002-4022-5998; Kim, Min-Sun/0000-0001-9952-0038; Nguyen
   Duc, Hai/0000-0001-8419-7784
FU National Research Foundation of Korea (NRF) - Korean government (MEST)
   [NRF2013R1A1A3008851, 2018R1D1A1B07049610]
FX This study was supported by the National Research Foundation of Korea
   (NRF) funded by the Korean government (MEST) (grant nos.
   NRF2013R1A1A3008851 and 2018R1D1A1B07049610).
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NR 70
TC 35
Z9 36
U1 0
U2 14
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD MAY
PY 2021
VL 10
IS 5
AR 808
DI 10.3390/antiox10050808
PG 14
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA SG3SA
UT WOS:000653360400001
PM 34069726
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Tang, Q
   Liu, ZF
   Tang, Y
   Tan, AH
   Gao, Y
   Lu, Z
   Wang, QY
   Chen, YC
   Wu, CL
   Zhang, HY
   Yang, XB
   Mo, ZN
AF Tang, Qin
   Liu, Zhenfang
   Tang, Yan
   Tan, Aihua
   Gao, Yong
   Lu, Zheng
   Wang, Qiuyan
   Chen, Yingchun
   Wu, Chunlei
   Zhang, Haiying
   Yang, Xiaobo
   Mo, Zengnan
TI High serum ferritin level is an independent risk factor for metabolic
   syndrome in a Chinese male cohort population
SO DIABETOLOGY & METABOLIC SYNDROME
LA English
DT Article
DE Metabolic syndrome; Serum ferritin; Central obesity; Hypertension;
   Triglycerides; High-density lipoprotein cholesterol
ID BODY IRON STORES; INSULIN-RESISTANCE; OXIDATIVE STRESS; KOREAN MEN;
   ASSOCIATION; OBESITY; TRANSFERRIN; DAMAGE; AGE
AB Background: Elevated serum ferritin levels have been reported to contribute to metabolic syndrome (MetS). We examined the association of serum ferritin levels with the development of MetS in a representative sample of Chinese male adult population.
   Method: The data came from the 2009-2013 Fangchenggang Area Males Health and Examination Survey (FAMHES). We combined a cross-sectional study of 2417 males and a longitudinal study of 857 males who participated in the FAMHES.
   Result: The serum ferritin level of MetS was higher than that of nonMetS (median and percentiles 25-75: 447.4 (294.1-612.4) vs. 302.4 (215.0-435.8) ng/ml, p < 0.01). A positive correlation between ferritin concentrations and blood pressure (Systolic BP: R = 0.110, Diastolic BP: R = 0.158), waist circumference (R = 0.333), fasting glucose (R = 0.089), triglyceride (R = 0.315) and low high-density lipoprotein cholesterol (R = 0.130) was significant (all p < 0.001). Compared with the level of ferritin in the group with no MetS component, the group with all five MetS components had a higher ferritin level (554.7 (340.1-606.4) vs. 274.2 (198.2-384.4) ng/ml). The odd radio (OR) was higher for MetS in the highest ferritin quartile (OR = 2.29, 95% CI = 1.47-3.54) compared with the lowest ferritin quartile after adjustment for multi-factors. After 4-year follow up, 79 subjects newly diagnosed with MetS in 857 cohort male participants in 2013. Compared with the lowest ferritin quartile, the RR of the highest ferritin quartile was 2.55 (95% CI = 1.30-5.00) after multiple adjustments (p < 0.01).
   Conclusion: Our findings confirm that the serum ferritin level is associated with the independent components of MetS, and elevated ferritin level is an independent risk factor for MetS development in the Chinese male population during the 4-year follow-up period.
C1 [Tang, Qin; Tang, Yan; Tan, Aihua; Gao, Yong; Lu, Zheng; Wang, Qiuyan; Chen, Yingchun; Wu, Chunlei; Zhang, Haiying; Yang, Xiaobo; Mo, Zengnan] Guangxi Med Univ, Ctr Genom & Personalized Med, Nanning 530021, Guangxi, Peoples R China.
   [Tang, Qin; Tang, Yan; Wang, Qiuyan; Chen, Yingchun; Yang, Xiaobo; Mo, Zengnan] Guangxi Key Lab Genom & Personalized Med, Nanning 530021, Guangxi, Peoples R China.
   [Tang, Qin; Tang, Yan; Wang, Qiuyan; Chen, Yingchun; Yang, Xiaobo; Mo, Zengnan] Guangxi Collaborat Innovat Ctr Genom & Personaliz, Nanning 530021, Guangxi, Peoples R China.
   [Liu, Zhenfang] Guangxi Med Univ, Affiliated Hosp 1, Hematol Dept, Nanning 530021, Guangxi, Peoples R China.
   [Tan, Aihua] Guangxi Med Univ, Affiliated Tumor Hosp, Dept Chemotherapy, Nanning 530021, Guangxi, Peoples R China.
   [Lu, Zheng; Mo, Zengnan] Guangxi Med Univ, Affiliated Hosp 1, Inst Urol & Nephrol, Nanning 530021, Guangxi, Peoples R China.
   [Zhang, Haiying; Yang, Xiaobo] Guangxi Med Univ, Sch Publ Hlth, Dept Occupat Hlth & Environm Hlth, Nanning 530021, Guangxi, Peoples R China.
C3 Guangxi Medical University; Guangxi Medical University; Guangxi Medical
   University; Guangxi Medical University; Guangxi Medical University
RP Yang, XB (corresponding author), Guangxi Med Univ, Ctr Genom & Personalized Med, Nanning 530021, Guangxi, Peoples R China.
EM yxbo21021@163.com
RI Yang, Xiaobo/G-3854-2016; Wu, Chunlei/ABF-4720-2020
OI mo, zengnan/0000-0002-3047-3138
FU Guangxi Science Fund for Distinguished Young Scholars [2012jjFA40011];
   Guangxi science and technology development project [1355007-1]; Program
   for New Century Excellent Talents in University [NCET-12-0653]; National
   Natural Science Foundations of China [81260130, 81460159]
FX This study was funded by Guangxi Science Fund for Distinguished Young
   Scholars (2012jjFA40011); Guangxi science and technology development
   project (1355007-1); Program for New Century Excellent Talents in
   University (NCET-12-0653); and National Natural Science Foundations of
   China (81260130 and 81460159).
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NR 39
TC 16
Z9 18
U1 0
U2 13
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1758-5996
J9 DIABETOL METAB SYNDR
JI Diabetol. Metab. Syndr.
PD FEB 24
PY 2015
VL 7
AR 11
DI 10.1186/s13098-015-0004-9
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA CC3MV
UT WOS:000350254500001
PM 25741386
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Robich, MP
   Chu, LM
   Burgess, TA
   Feng, J
   Han, Y
   Nezafat, R
   Leber, MP
   Laham, RJ
   Manning, WJ
   Sellke, FW
AF Robich, Michael P.
   Chu, Louis M.
   Burgess, Thomas A.
   Feng, Jun
   Han, Yuchi
   Nezafat, Reza
   Leber, Michael P.
   Laham, Roger J.
   Manning, Warren J.
   Sellke, Frank W.
TI Resveratrol Preserves Myocardial Function and Perfusion in Remote
   Nonischemic Myocardium in a Swine Model of Metabolic Syndrome
SO JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
LA English
DT Article
ID CORONARY-ARTERY-DISEASE; ENDOTHELIAL GROWTH-FACTOR; CARDIAC-MUSCLE;
   ISCHEMIA; PGC-1-ALPHA; DYSFUNCTION; TARGETS; DEATH; SIRT1; RISK
AB BACKGROUND: Resveratrol has been shown to reverse some of the detrimental effects of metabolic syndrome (MetS). We sought to define the impact of supplemental resveratrol on normal myocardium remote from an ischemic territory in a swine model of MetS and chronic myocardial ischemia.
   STUDY DESIGN: Yorkshire swine were fed a normal diet (control), a high cholesterol diet (HCD), or a high cholesterol diet with orally supplemented resveratrol (HCD-R; 100 mg/kg/day). Four weeks after diet modification, myocardial ischemia was induced by ameroid constrictor placement. Seven weeks later, myocardial tissue from a territory remote from the ischemia was harvested. Animals in the HCD and HCD-R groups underwent functional cardiac MRI before ischemia and before sacrifice. Tissue was harvested for protein expression analysis.
   RESULTS: After 7 weeks of ischemia, regional left ventricular systolic function was significantly increased in HCD-R as compared with HCD animals. During ventricular pacing the HCD group had significantly decreased flow (p = 0.03); perfusion in the HCD-R was preserved as compared with the control. There was no difference in microvascular relaxation. Expression of metabolic proteins Sirt-1 (p = 0.002), AMPkinase (p = 0.02), and carnitine palmitoyltransferase-I (p = 0.002) were upregulated in the HCD-R group. Levels of protein oxidative stress were significantly increased in the HCD and HCD-R groups, as compared with the controls (p = 0.003). Activated endothelial nitric oxide synthase (eNOS) was increased in the HCD-R group (p = 0.01). There was no difference in myocardial endothelial cell density between the groups; however, dividing endothelial cells were decreased in the HCD and HCD-R groups (p = 0.006).
   CONCLUSIONS: Resveratrol supplementation improves regional left ventricular function and preserves perfusion to myocardium remote from an area of ischemia in an animal model of metabolic syndrome and chronic myocardial ischemia. (J Am Coll Surg 2012;215:681-689. (c) 2012 by the American College of Surgeons)
C1 [Robich, Michael P.; Burgess, Thomas A.; Feng, Jun; Leber, Michael P.; Sellke, Frank W.] Brown Univ, Cardiovasc Res Ctr, Warren Alpert Med Sch, Dept Surg,Div Cardiothorac Surg, Providence, RI 02905 USA.
   [Robich, Michael P.; Chu, Louis M.] Harvard Univ, Beth Israel Deaconess Med Ctr, Dept Surg, Sch Med,Div Cardiothorac Surg, Boston, MA 02215 USA.
   [Han, Yuchi; Nezafat, Reza; Laham, Roger J.; Manning, Warren J.] Harvard Univ, Beth Israel Deaconess Med Ctr, Dept Med, Sch Med,Div Cardiol, Boston, MA 02215 USA.
   [Manning, Warren J.] Harvard Univ, Beth Israel Deaconess Med Ctr, Dept Radiol, Sch Med, Boston, MA 02215 USA.
C3 Brown University; Harvard University; Harvard University Medical
   Affiliates; Beth Israel Deaconess Medical Center; Harvard Medical
   School; Harvard University; Harvard University Medical Affiliates; Beth
   Israel Deaconess Medical Center; Harvard Medical School; Harvard
   University; Harvard Medical School; Harvard University Medical
   Affiliates; Beth Israel Deaconess Medical Center
RP Sellke, FW (corresponding author), Brown Univ, Cardiovasc Res Ctr, Warren Alpert Med Sch, Dept Surg,Div Cardiothorac Surg, 2 Dudley St,MOC 360, Providence, RI 02905 USA.
EM fsellke@lifespan.org
OI Han, Yuchi/0000-0001-7582-1848; Feng, Jun/0000-0003-4762-7532
FU National Health Institute, National Heart, Lung, and Blood Institute
   (NHLBI) [RO1HL46716, RO1HL69024]; NIH [5T32-HL0074, 5T32-HL007734-19];
   Irving Bard Memorial Fellowship;  [5T32-HL094300]
FX This work was supported by the National Health Institute, National
   Heart, Lung, and Blood Institute (NHLBI RO1HL46716 and RO1HL69024), NIH
   5T32-HL0074 (M.P.R.), NIH 5T32-HL007734-19 (MPR), 5T32-HL094300 (LMC),
   and the Irving Bard Memorial Fellowship (MPR, LMC).
CR [Anonymous], EUR J CARDIOTHORAC S
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NR 26
TC 22
Z9 23
U1 0
U2 5
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1072-7515
J9 J AM COLL SURGEONS
JI J. Am. Coll. Surg.
PD NOV
PY 2012
VL 215
IS 5
BP 681
EP 689
DI 10.1016/j.jamcollsurg.2012.06.417
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 043UR
UT WOS:000311575600013
PM 22867714
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Rosenson, RS
   Wolff, DA
   Huskin, AL
   Helenowski, IB
   Rademaker, AW
AF Rosenson, Robert S.
   Wolff, David A.
   Huskin, Anna L.
   Helenowski, Irene B.
   Rademaker, Alfred W.
TI Fenofibrate therapy ameliorates fasting and postprandial
   lipoproteinemia, oxidative stress, and the inflammatory response in
   subjects with hypertriglyceridemia and the metabolic syndrome
SO DIABETES CARE
LA English
DT Article
ID LOW-DENSITY-LIPOPROTEIN; MAGNETIC-RESONANCE-SPECTROSCOPY;
   CORONARY-ARTERY DISEASE; ENDOTHELIAL FUNCTION; INSULIN-RESISTANCE;
   CARDIOVASCULAR-DISEASE; PARTICLE-SIZE; HEART-DISEASE; ATHEROSCLEROSIS;
   RISK
AB OBJECTIVE- The aim of this study was to determine the effects of fenofibrate (160 mg/day) on fasting and postprandial lipoproteins, oxidized fatty acids, and inflammatory mediators in subjects with hypertriglyceridemia and the metabolic syndrome. RESEARCH DESIGN AND METHODS - Fifty-nine subjects with fasting hypertriglyceridemia (>= 1. 7 and <6.9 mmol/l) and two or more of the Adult Treatment Panel III criteria for the metabolic syndrome were randomly assigned to fenofibrate (160 mg/day) or placebo in a double-blind, controlled clinical trial. RESULTS - Fenofibrate treatment lowered fasting triglycerides (-46.1%, P < 0.0001) and postprandial (area under the curve) triglycerides (-45.4%, P < 0.0001) due to significant reductions in postprandial levels of large (-40.8%, P < 0.0001) and medium (-49.5%, P < 0.0001) VLDL particles. The number of fasting total LDL particles was reduced in fenofibratetreated subjects (- 19.0%, P = 0.0033) primarily due to reductions in small LDL particles (- 40.3 %, P < 0. 000 1); these treatment differences persisted postprandially. Fasting and postprandial oxidized fatty acids were reduced in fenofibrate-treated subjects compared with placebo-administered subjects (-15.3%, P = 0.0013, and 31.0%, P < 0.0001, respectively), and fenofibrate therapy lowered fasting and postprandial soluble vascular cell adhesion molecule-1 (VCAM-1) (- 10.9%, P = 0.0005, and - 12.0%, P = 0.0001, respectively) as well as fasting and postprandial soluble intercellular adhesion molecule-1 (ICAM-1) (-14.8%, P < 0.0001, and - 15.3% P < 0.0001, respectively). Reductions in VCAM-1 and ICAM-1 were correlated with reductions in fasting and postprandial large VLDL particles (P < 0.0001) as well as postprandial oxidized fatty acids (P < 0.0005). CONCLUSIONS - Triglyceride-lowering therapy with fenofibrate reduced fasting and postprandial free fatty acid oxidation and inflammatory responses, and these antiatherosclerotic effects were most highly correlated with reductions in large VLDL particles.
C1 Univ Michigan, Div Cardiovasc Med, Ann Arbor, MI 48106 USA.
   Northwestern Univ, Feinberg Sch Med, Div Cardiol, Lipoprot & Hemorheol Res Facil,Div Cardiol, Chicago, IL 60611 USA.
   Northwestern Univ, Feinberg Sch Med, Dept Prevent Med, Chicago, IL 60611 USA.
C3 University of Michigan System; University of Michigan; Northwestern
   University; Feinberg School of Medicine; Northwestern University;
   Feinberg School of Medicine
RP Rosenson, RS (corresponding author), Univ Michigan, Div Cardiovasc Med, Dominos Farms,24 Frank Lloyd Wright Dr,Lobby A, Ann Arbor, MI 48106 USA.
EM rrosenso@umich.edu
RI Rosenson, Robert/MDS-6957-2025
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NR 41
TC 93
Z9 102
U1 0
U2 0
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0149-5992
EI 1935-5548
J9 DIABETES CARE
JI Diabetes Care
PD AUG
PY 2007
VL 30
IS 8
BP 1945
EP 1951
DI 10.2337/dc07-0015
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 197QH
UT WOS:000248570200001
PM 17483155
OA Bronze
DA 2025-06-11
ER

PT J
AU Pérez-Torres, I
   Castrejón-Téllez, V
   Soto, ME
   Rubio-Ruiz, ME
   Manzano-Pech, L
   Guarner-Lans, V
AF Perez-Torres, Israel
   Castrejon-Tellez, Vicente
   Soto, Maria Elena
   Rubio-Ruiz, Maria Esther
   Manzano-Pech, Linaloe
   Guarner-Lans, Veronica
TI Oxidative Stress, Plant Natural Antioxidants, and Obesity
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE oxidative stress; obesity; antioxidants; natural products
ID NF-KAPPA-B; ADIPOSE-TISSUE INFLAMMATION; DIETARY ISOFLAVONE INTAKE;
   HIBISCUS-SABDARIFFA L.; TUMOR-NECROSIS-FACTOR; FATTY LIVER-DISEASE;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; LIPID-METABOLISM;
   CARDIOVASCULAR-DISEASE
AB Oxidative stress is important in the pathophysiology of obesity, altering regulatory factors of mitochondrial activity, modifying the concentration of inflammation mediators associated with a large number and size of adipocytes, promoting lipogenesis, stimulating differentiation of preadipocytes to mature adipocytes, and regulating the energy balance in hypothalamic neurons that control appetite. This review discusses the participation of oxidative stress in obesity and the important groups of compounds found in plants with antioxidant properties, which include (a) polyphenols such as phenolic acids, stilbenes, flavonoids (flavonols, flavanols, anthocyanins, flavanones, flavones, flavanonols, and isoflavones), and curcuminoids (b) carotenoids, (c) capsaicinoids and casinoids, (d) isothiocyanates, (e) catechins, and (f) vitamins. Examples are analyzed, such as resveratrol, quercetin, curcumin, ferulic acid, phloretin, green tea, Hibiscus Sabdariffa, and garlic. The antioxidant activities of these compounds depend on their activities as reactive oxygen species (ROS) scavengers and on their capacity to prevent the activation of NF-kappa B (nuclear factor kappa-light-chain-enhancer of activated B cells), and reduce the expression of target genes, including those participating in inflammation. We conclude that natural compounds have therapeutic potential for diseases mediated by oxidative stress, particularly obesity. Controlled and well-designed clinical trials are still necessary to better know the effects of these compounds.
C1 [Perez-Torres, Israel; Manzano-Pech, Linaloe] Inst Nacl Cardiol Ignacio Chavez, Dept Mol Biomed, Tlalpan 14080, Mexico.
   [Castrejon-Tellez, Vicente; Rubio-Ruiz, Maria Esther; Guarner-Lans, Veronica] Inst Nacl Cardiol Ignacio Chavez, Dept Physiol, Tlalpan 14080, Mexico.
   [Soto, Maria Elena] Inst Nacl Cardiol Ignacio Chavez, Dept Immunol, Tlalpan 14080, Mexico.
C3 National Institute of Cardiology - Mexico; National Institute of
   Cardiology - Mexico; National Institute of Cardiology - Mexico
RP Guarner-Lans, V (corresponding author), Inst Nacl Cardiol Ignacio Chavez, Dept Physiol, Tlalpan 14080, Mexico.
EM israel.perez@cardiologia.org.mx; vicente.castrejon@cardiologia.org.mx;
   elena.soto@cardiologia.org.mx; esther.rubio@cardiologia.org.mx;
   loe_mana@hotmail.com; veronica.guarner@cardiologia.org.mx
RI V, Guarner/AFW-2513-2022; Pérez Torres, Israel/AAE-2579-2022
OI Perez-Torres, Israel/0000-0001-6510-2954
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NR 215
TC 251
Z9 264
U1 30
U2 182
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD FEB
PY 2021
VL 22
IS 4
AR 1786
DI 10.3390/ijms22041786
PG 26
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA QP3QL
UT WOS:000623751800001
PM 33670130
OA gold, Green Published
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Le Blanc, S
   Villarroel, P
   Candia, V
   Gavilán, N
   Soto, N
   Pérez-Bravo, F
   Arredondo, M
AF Le Blanc, Solange
   Villarroel, Pia
   Candia, Valeria
   Gavilan, Natalia
   Soto, Nestor
   Perez-Bravo, Francisco
   Arredondo, Miguel
TI Type 2 diabetic patients and their offspring show altered parameters of
   iron status, oxidative stress and genes related to mitochondrial
   activity
SO BIOMETALS
LA English
DT Article
DE Iron; Oxidative stress; Bcl2/Bax ratio; Mitofusin; Diabetes mellitus
ID LOW-DENSITY-LIPOPROTEIN; METABOLIC SYNDROME; HEME OXYGENASE-1;
   INSULIN-RESISTANCE; OBESITY; MELLITUS; GLUCOSE; HYPERINSULINEMIA;
   ATHEROSCLEROSIS; DYSFUNCTION
AB Type 2 diabetes (T2D) is directly related to alterations in iron status, oxidative stress and decreased mitochondrial activity, but the possible interaction of these parameters among T2D patients and their offspring is unclear. The whole study included 301 subjects: 77 T2D patients and one of their offspring and 51 control subjects with one of their offspring. The offspring were older than 20 years old. We measured parameters of iron status (serum iron, ferritin and transferrin receptor), diabetes (pre and post-prandial glucose, insulin, lipids), oxidative stress (Heme oxygenase activity, TBARS, SOD, GSH, Vitamin E), as well as the expression of genes in blood leukocytes related to mitochondrial apopotosis (mitofusin and Bcl/Bax ratios). The offspring of T2D patients had increased levels of serum ferritin (P < 0.01) and lower transferrin receptor (P < 0.008); higher insulin (P < 0.03) and total and LDL cholesterol; higher heme oxygenase and SOD activities increased TBARS and lower GSH; decreased mitofusin and Bcl/Bax expression ratios compared to offspring of normal subjects. These results suggest that the offspring of T2D patients could have an increased metabolic risk of develop a cardiovascular disease mediated by oxidative stress and iron status.
C1 [Le Blanc, Solange; Villarroel, Pia; Candia, Valeria; Arredondo, Miguel] Univ Chile, Lab Micronutrientes, INTA, Santiago, Chile.
   [Gavilan, Natalia] Consultorio Eduardo Frei Montalva, Santiago, Chile.
   [Soto, Nestor] Hosp San Borja Arriaran, SSMC, Unidad Endocrinol & Diabet, Santiago, Chile.
   [Perez-Bravo, Francisco] Univ Chile, Fac Med, Dept Nutr, Santiago 7, Chile.
C3 Universidad de Chile; Universidad de Chile; Universidad de Chile
RP Arredondo, M (corresponding author), Univ Chile, Lab Micronutrientes, INTA, El Libano 5524, Santiago, Chile.
EM marredon@inta.uchile.cl
FU Fondo Nacional de Ciencia y Tecnologia (FONDECYT), Chile [1085173]
FX We thank the staff from the Diabetic Program, Nutrition Unit, of San
   Juan de Dios Hospital, for their teamwork and persistent efforts in this
   project. This work was supported by Grant 1085173 from Fondo Nacional de
   Ciencia y Tecnologia (FONDECYT), Chile to M. Arredondo.
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NR 50
TC 14
Z9 15
U1 0
U2 8
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0966-0844
EI 1572-8773
J9 BIOMETALS
JI Biometals
PD AUG
PY 2012
VL 25
IS 4
BP 725
EP 735
DI 10.1007/s10534-012-9540-z
PG 11
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 964XX
UT WOS:000305731100009
PM 22450556
DA 2025-06-11
ER

PT J
AU Rodrigo, S
   Rodríguez, L
   Otero, P
   Panadero, MI
   García, A
   Barbas, C
   Roglans, N
   Ramos, S
   Goya, L
   Laguna, JC
   Alvarez-Millán, JJ
   Bocos, C
AF Rodrigo, Silvia
   Rodriguez, Lourdes
   Otero, Paola
   Panadero, Maria I.
   Garcia, Antonia
   Barbas, Coral
   Roglans, Nuria
   Ramos, Sonia
   Goya, Luis
   Laguna, Juan C.
   Alvarez-Millan, Juan J.
   Bocos, Carlos
TI Fructose during pregnancy provokes fetal oxidative stress: The key role
   of the placental heme oxygenase-1
SO MOLECULAR NUTRITION & FOOD RESEARCH
LA English
DT Article
DE Fructose; Heme oxygenase-1; Oxidative stress; Placenta; Pregnancy
ID FATTY-ACIDS; RAT; CONSUMPTION; RESISTANCE; GESTATION; INSULIN; RISK;
   TRIGLYCERIDES; DYSFUNCTION; GLUTATHIONE
AB Scope: One of the features of metabolic syndrome caused by liquid fructose intake is an impairment of redox status. We have investigated whether maternal fructose ingestion modifies the redox status in pregnant rats and their fetuses.
   Methods and results: Fructose (10% wt/vol) in the drinking water of rats throughout gestation, leads to maternal hepatic oxidative stress. However, this change was also observed in glucose-fed rats and, in fact, both carbohydrates produced a decrease in antioxidant enzyme activity. Surprisingly, mothers fed carbohydrates displayed low plasma lipid oxidation. In contrast, fetuses from fructose-fed mothers showed elevated levels of plasma lipoperoxides versus fetuses from control or glucose-fed mothers. Interestingly, a clearly augmented oxidative stress was observed in placenta of fructose-fed mothers, accompanied by a lower expression of the transcription factor Nuclear factor-erythroid 2-related factor-2 (Nrf2) and its target gene, heme oxygenase-1 (HO-1), a potent antioxidant molecule. Moreover, histone deacetylase 3 (HDAC3) that has been proposed to upregulate HO-1 expression by stabilizing Nrf2, exhibited a diminished expression in placenta of fructose-supplemented mothers.
   Conclusions: Maternal fructose intake provoked an imbalanced redox status in placenta and a clear diminution of HO-1 expression, which could be responsible for the augmented oxidative stress found in their fetuses.
C1 [Rodrigo, Silvia; Rodriguez, Lourdes; Otero, Paola; Panadero, Maria I.; Bocos, Carlos] Univ San Pablo CEU, Fac Farm, Madrid, Spain.
   [Garcia, Antonia; Barbas, Coral] Univ San Pablo CEU, Fac Farm, Ctr Metabol & Bioanal CEMBIO, Madrid, Spain.
   [Roglans, Nuria; Laguna, Juan C.] Univ Barcelona, Fac Farm, IBUB, CIBERobn, Barcelona, Spain.
   [Ramos, Sonia; Goya, Luis] CSIC, ICTAN, Dept Metab & Nutr, Madrid, Spain.
   [Alvarez-Millan, Juan J.] CQS Lab, Madrid, Spain.
C3 San Pablo CEU University; San Pablo CEU University; University of
   Barcelona; CIBER - Centro de Investigacion Biomedica en Red; CIBEROBN;
   Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Instituto
   de Ciencia y Tecnologia de Alimentos y Nutricion (ICTAN)
RP Bocos, C (corresponding author), Univ San Pablo CEU, Fac Farm, Madrid, Spain.
EM carbocos@ceu.es
RI Roglans, Núria/ABH-1242-2020; Martín, Maria Angeles/JAO-0626-2023;
   BOCOS, CARLOS/B-8460-2015; Laguna, Juan C/C-5481-2017; Otero,
   Paola/H-9150-2015; Panadero, Maria I./L-4262-2017; Ramos,
   Sonia/K-4594-2012; Garcia, Antonia/C-4296-2008; Barbas,
   Coral/K-3871-2014
OI BOCOS, CARLOS/0000-0003-0364-5958; Laguna, Juan C/0000-0002-7082-0704;
   Otero, Paola/0000-0001-5107-6185; Panadero, Maria
   I./0000-0003-0459-3539; Ramos, Sonia/0000-0003-2649-2616; Alvarez
   Millan, Juan Jose/0000-0002-6774-4958; Garcia,
   Antonia/0000-0002-1521-8489; Roglans, Nuria/0000-0002-5018-021X; Barbas,
   Coral/0000-0003-4722-491X
FU Instituto de Salud Carlos III-Subdireccion General de Evaluacion y
   Fomento de la Investigacion [PI-09/02192]; European Community FEDER
   funds; Ayuda a Grupo en Consolidacion Universidad San Pablo-CEU
   [USP-BS-PCON02/2015]; Banco de Santander [USP-BS-PCON02/2015]
FX The authors thank Jose M. Garrido for his help in handling the rats, and
   Brian Crilly for his editorial help. This work was supported by grants
   from the Instituto de Salud Carlos III-Subdireccion General de
   Evaluacion y Fomento de la Investigacion (PI-09/02192), European
   Community FEDER funds, as well as the Ayuda a Grupo en Consolidacion
   Universidad San Pablo-CEU and Banco de Santander (USP-BS-PCON02/2015).
   Silvia Rodrigo is a FUSP-CEU fellowship. C. Bo. and J.J.A-M conceived
   and designed the study.
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NR 53
TC 22
Z9 25
U1 0
U2 12
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1613-4125
EI 1613-4133
J9 MOL NUTR FOOD RES
JI Mol. Nutr. Food Res.
PD DEC
PY 2016
VL 60
IS 12
BP 2700
EP 2711
DI 10.1002/mnfr.201600193
PG 12
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA EJ3ZV
UT WOS:000393156600016
PM 27545118
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Guldan, M
   Unlu, S
   Abdel-Rahman, SM
   Ozbek, L
   Gaipov, A
   Covic, A
   Soler, MJ
   Covic, A
   Kanbay, M
AF Guldan, Mustafa
   Unlu, Selen
   Abdel-Rahman, Sama Mahmoud
   Ozbek, Lasin
   Gaipov, Abduzhappar
   Covic, Andreea
   Soler, Maria Jose
   Covic, Adrian
   Kanbay, Mehmet
TI Understanding the Role of Sex Hormones in Cardiovascular Kidney
   Metabolic Syndrome: Toward Personalized Therapeutic Approaches
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Review
DE sex hormone; chronic kidney disease; metabolic syndrome; cardiovascular
   kidney metabolic syndrome; diabetes mellitus
ID ESTROGEN-RECEPTOR-ALPHA; ANDROGEN-DEPRIVATION THERAPY; 17
   BETA-ESTRADIOL; SPONTANEOUSLY HYPERTENSIVE-RATS; RENIN-ANGIOTENSIN
   SYSTEM; CHRONIC HEART-FAILURE; C-REACTIVE PROTEIN; NF-KAPPA-B;
   REPLACEMENT THERAPY; GENDER-DIFFERENCES
AB Cardiovascular kidney metabolic (CKM) syndrome represents a complex interplay of cardiovascular disease (CVD), chronic kidney disease (CKD), and metabolic comorbidities, posing a significant public health challenge. Gender exerts a critical influence on CKM syndrome, affecting the disease severity and onset through intricate interactions involving sex hormones and key physiological pathways such as the renin-angiotensin system, oxidative stress, inflammation, vascular disease and insulin resistance. It is widely known that beyond the contribution of traditional risk factors, men and women exhibit significant differences in CKM syndrome and its components, with distinct patterns observed in premenopausal women and postmenopausal women compared to men. Despite women generally experiencing a lower incidence of CVD, their outcomes following cardiovascular events are often worse compared to men. The disparities also extend to the treatment approaches for kidney failure, with a higher prevalence of dialysis among men despite women exhibiting higher rates of CKD. The impact of endogenous sex hormones, the correlations between CKM and its components, as well as the long-term effects of treatment modalities using sex hormones, including hormone replacement therapies and gender-affirming therapies, have drawn attention to this topic. Current research on CKM syndrome is hindered by the scarcity of large-scale studies and insufficient integration of gender-specific considerations into treatment strategies. The underlying mechanisms driving the gender disparities in the pathogenesis of CKM syndrome, including the roles of estrogen, progesterone and testosterone derivatives, remain poorly understood, thus limiting their application in personalized therapeutic interventions. This review synthesizes existing knowledge to clarify the intricate relationship between sex hormones, gender disparities, and the progression of CVD within CKM syndrome. By addressing these knowledge gaps, this study aims to guide future research efforts and promote tailored approaches for effectively managing CKD syndrome.
C1 [Guldan, Mustafa; Unlu, Selen; Abdel-Rahman, Sama Mahmoud; Ozbek, Lasin] Koc Univ, Sch Med, Dept Med, TR-34450 Istanbul, Turkiye.
   [Gaipov, Abduzhappar] Nazarbayev Univ, Sch Med, Dept Med, Astana 010000, Kazakhstan.
   [Covic, Andreea; Covic, Adrian] Grigore T Popa Univ Med, Dept Nephrol, Iasi 700115, Romania.
   [Soler, Maria Jose] Vall dHebron Univ Hosp, Vall dHebron Inst Res, Nephrol Dept, Barcelona 08035, Spain.
   [Soler, Maria Jose] Glomerular Compleja Sistema Nacl Salud Espana CSUR, Ctr Referencia Enfermedad, RICORS2040 Kidney Dis, Barcelona 08003, Spain.
   [Soler, Maria Jose] GEENDIAB Grp Espanol Estudio Nefropatia Diabetica, Santander 39008, Spain.
   [Kanbay, Mehmet] Koc Univ, Sch Med, Dept Med, Div Nephrol, TR-34450 Istanbul, Turkiye.
C3 Koc University; Nazarbayev University; Grigore T Popa University of
   Medicine & Pharmacy; Hospital Universitari Vall d'Hebron; Koc University
RP Covic, A (corresponding author), Grigore T Popa Univ Med, Dept Nephrol, Iasi 700115, Romania.
EM mguldan17@ku.edu.tr; sunlu20@ku.edu.tr; srahman20@ku.edu.tr;
   lozbek18@ku.edu.tr; abduzhappar.gaipov@nu.edu.kz;
   andreea.covic@gmail.com; mjsoler01@gmail.com; accovic@gmail.com;
   mkanbay@ku.edu.tr
RI Covic, Andreea/IAQ-6522-2023; Soler, Maria/AAP-4454-2020; 1,
   1/IAO-4606-2023; Guldan, Mustafa/HTN-5016-2023; Covic,
   Adrian/G-5017-2016; Gaipov, Abduzhappar/G-3059-2012
OI Abdel-Rahman, Sama/0009-0005-1980-7749; Ozbek,
   Lasin/0000-0002-2828-555X; Guldan, Mustafa/0000-0002-0480-5370; Covic,
   Adrian/0000-0002-9985-2486; Kanbay, Mehmet/0000-0002-1297-0675; Soler,
   Maria Jose/0000-0003-3621-0766; Gaipov, Abduzhappar/0000-0002-9844-8772
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NR 220
TC 10
Z9 11
U1 10
U2 16
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD AUG
PY 2024
VL 13
IS 15
AR 4354
DI 10.3390/jcm13154354
PG 28
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA C1K3F
UT WOS:001287015300001
PM 39124622
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Ye, YN
   Zhang, LX
   Wang, AN
   Wang, YX
   Wang, SQ
   Ning, G
   Mu, YM
AF YE, Yingnan
   ZHANG, Linxi
   WANG, Anping
   Wang, Yuxia
   WANG, Shiqing
   NING, Guang
   MU, Yiming
TI Association of sleep duration with stroke, myocardial infarction, and
   tumors in a Chinese population with metabolic syndrome: a retrospective
   study
SO LIPIDS IN HEALTH AND DISEASE
LA English
DT Article
DE Sleep duration; Metabolic syndrome; Stroke; Myocardial infarction;
   Tumors; Cohort; Chinese population
ID RISK-FACTOR; PATTERNS; DISEASE; STRESS
AB Background Previous studies have suggested that abnormal sleep duration is associated with increased risk of metabolic syndrome (MetS). However, evidence on the association of sleep duration with stroke, myocardial infarction (MI) and tumors in populations with MetS is limited. Methods A total of 8968 participants (2754 with MetS at baseline) were recruited in this retrospective study between March 2012 and December 2012. The baseline characteristics and information on sleep duration were collected by self-reported questionnaires. In addition, physical examination and blood test were also performed. The outcome events in this study were new onset of stroke, MI and tumors during subsequent follow-up. Multivariate logistic regressions were adopted to investigate the relationships between sleep duration and outcome events among different sleep duration groups (< 6 h, 6-7 h, 7-8 h [reference], 8-9 h, and > 9 h per day) in participants with MetS. Results The mean self-reported total sleep duration was 7.8 +/- 1.2 h. Compared with participants with MetS slept for 7-8 h per day, the adjusted odds ratios (ORs) for those slept for > 9 h in stroke, MI and tumors were 2.014 (95% confidence interval [CI]: 1.184-3.426,P = 0.010), 1.731 (95% CI: 0.896-3.344,P = 0.102) and 2.159 (95% CI: 0.991-4.704,P = 0.053), respectively, whereas the adjusted ORs for those slept for < 6 h in stroke, MI and tumors were 2.249 (95% CI: 0.973-5.195,P = 0.058), 1.213 (95% CI, 0.358-4.104,P = 0.756) and 1.743 (95% CI, 0.396-7.668,P = 0.462), respectively. Conclusions Long sleep duration (> 9 h) significantly increased the risk of stroke but not MI and tumors in individuals with MetS compared with 7-8 h of sleep duration. Short sleep duration (< 6 h) was not associated with the increased risk of stroke, MI and tumors in individuals with MetS.
C1 [YE, Yingnan; ZHANG, Linxi; WANG, Anping; Wang, Yuxia; WANG, Shiqing; MU, Yiming] Nankai Univ, Dept Endocrinol, Chest Hosp, Sch Med, Tianjin 300071, Peoples R China.
   [YE, Yingnan; Wang, Yuxia; WANG, Shiqing; MU, Yiming] Chinese Peoples Liberat Army Gen Hosp, Dept Endocrinol, Med Sch Chinese PLA, 28 Fuxing Rd, Beijing 100853, Peoples R China.
   [NING, Guang] Shanghai Jiao Tong Univ, Ruijin Hosp, Dept Endocrine & Metab Dis, Sch Med, Shanghai, Peoples R China.
C3 Nankai University; Chinese People's Liberation Army General Hospital;
   Shanghai Jiao Tong University
RP Mu, YM (corresponding author), Nankai Univ, Dept Endocrinol, Chest Hosp, Sch Med, Tianjin 300071, Peoples R China.
EM znmf89898@sohu.com
RI Martinez, Ramfis/I-7205-2019
FU Chinese Society of Endocrinology; Key Laboratory for Endocrine and
   Metabolic Diseases of Ministry of Health [1994DP131044]; National Key
   New Drug Creation and Manufacturing Program of Ministry of Science and
   Technology [2012ZX09303006-001]; National High Technology Research and
   Development Program of China (863 Program) [2011AA020107]; National
   Science and Technology Major Project 288 [2011ZX09307-001-08]
FX The present study was supported by the Chinese Society of Endocrinology,
   the Key Laboratory for Endocrine and Metabolic Diseases of Ministry of
   Health (1994DP131044), the National Key New Drug Creation and
   Manufacturing Program of Ministry of Science and Technology
   (2012ZX09303006-001), the National High Technology Research and
   Development Program of China (863 Program, 2011AA020107), and the
   National Science and Technology Major Project 288 (2011ZX09307-001-08).
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J9 LIPIDS HEALTH DIS
JI Lipids Health Dis.
PD JUN 27
PY 2020
VL 19
IS 1
AR 155
DI 10.1186/s12944-020-01328-1
PG 9
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA MF9FS
UT WOS:000545643900001
PM 32593309
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Zhang, H
   Fan, Q
   Xie, HY
   Lu, L
   Tao, R
   Wang, F
   Xi, R
   Hu, J
   Chen, QJ
   Shen, WF
   Zhang, RY
   Yan, XX
AF Zhang, Hang
   Fan, Qin
   Xie, Hongyang
   Lu, Lin
   Tao, Rong
   Wang, Fang
   Xi, Rui
   Hu, Jian
   Chen, Qiujing
   Shen, Weifeng
   Zhang, Ruiyan
   Yan, Xiaoxiang
TI Elevated Serum Cyclophilin B Levels Are Associated with the Prevalence
   and Severity of Metabolic Syndrome
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Article
DE cyclophilin B; CD147; metabolic syndrome; inflammation; cardiovascular
   risk
ID MATRIX METALLOPROTEINASES; CD147; INFLAMMATION; PROTEIN; ADHESION;
   RECEPTOR; DISEASE; OBESITY; CANCER; ROLES
AB Objective: Inflammation plays a central role in the pathogenesis of metabolic syndrome (MetS). Cyclophilin B (CypB) can be constitutively secreted in response to inflammatory stimuli and oxidative stress, participating in tissue or systemic inflammation. We investigated the relationship between CypB and MetS in both humans and mice.
   Methods: Serum CypB levels were determined in 211 subjects with MetS and 292 subjects without MetS (non-MetS) (133 healthy controls and 159 high-risk subjects with one to two MetS components). Additionally, CypB expression in metabolic organs was examined in mice fed with high-fat diet (HFD) and genetically obese (ob/ob) mice.
   Results: Serum CypB level was significantly higher in MetS subjects compared with both groups of non-MetS subjects (193.80 +/- 83.22 vs. 168.38 +/- 65.01 vs. 124.26 +/- 47.83 ng/mL, P < 0.001). Particularly, serum CypB level was significantly higher in subjects with hypertension, central obesity, diabetes mellitus or hyperglycemia, elevated levels of triglycerides, or reduced levels of high-density lipoprotein than in those without. Moreover, CypB was positively associated with the number of MetS components (r = 0.404, P < 0.001), indicating that a higher serum CypB level reflected more severe MetS. Multivariate regression revealed that a one SD increase in CypB was associated with an odds ratio of 1.506 (1.080-2.101, P = 0.016) for MetS prevalence after adjusting for age, gender, conventional risk factors, and medication. Stratified analyses by age and gender demonstrated that subjects >60 years old with higher CypB levels were more likely to have MetS, and the risk for MetS was higher and more significant in women compared with men. Additionally, CypB expression levels were lower at baseline and dramatically enhanced in metabolic organs (such as the liver) and visceral and subcutaneous adipose tissue from HFD-induced obese mice and ob/ob mice.
   Conclusion: Increased CypB levels were significantly and independently associated with the presence and severity of MetS, indicating that CypB could be used as a novel biomarker and clinical predictor of MetS.
C1 [Zhang, Hang; Fan, Qin; Xie, Hongyang; Lu, Lin; Tao, Rong; Wang, Fang; Xi, Rui; Hu, Jian; Shen, Weifeng; Zhang, Ruiyan; Yan, Xiaoxiang] Shanghai Jiao Tong Univ, Sch Med, Rui Jin Hosp, Dept Cardiol, Shanghai, Peoples R China.
   [Zhang, Hang; Fan, Qin; Xie, Hongyang; Lu, Lin; Chen, Qiujing; Yan, Xiaoxiang] Shanghai Jiao Tong Univ, Sch Med, Inst Cardiovasc Dis, Shanghai, Peoples R China.
C3 Shanghai Jiao Tong University; Shanghai Jiao Tong University
RP Yan, XX (corresponding author), Shanghai Jiao Tong Univ, Sch Med, Rui Jin Hosp, Dept Cardiol, Shanghai, Peoples R China.; Yan, XX (corresponding author), Shanghai Jiao Tong Univ, Sch Med, Inst Cardiovasc Dis, Shanghai, Peoples R China.
EM cardexyanxx@hotmail.com
RI Zhang, Ruiyan/HHC-5329-2022; Shen, Weifeng/AAE-2493-2022
FU National Natural Science Foundation of China [81400362, 81670457,
   81570316]; Shanghai Rising-Star Program grant [17QA1402300]; Municipal
   Human Resources Development Program for Outstanding Young Talents in
   Medical and Health Sciences in Shanghai [2017YQ017]
FX This study was supported by the National Natural Science Foundation of
   China (81400362 and 81670457 to XY; 81570316 to RZ), a Shanghai
   Rising-Star Program grant (17QA1402300 to XY), and a Municipal Human
   Resources Development Program for Outstanding Young Talents in Medical
   and Health Sciences in Shanghai (2017YQ017 to XY). There are no
   relationships with industry.
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NR 36
TC 22
Z9 22
U1 0
U2 7
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD DEC 22
PY 2017
VL 8
AR 360
DI 10.3389/fendo.2017.00360
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA FQ8CI
UT WOS:000418590100001
PM 29312150
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Vangaveti, VN
   Jansen, H
   Kennedy, RL
   Malabu, UH
AF Vangaveti, Venkat N.
   Jansen, Holger
   Kennedy, Richard Lee
   Malabu, Usman H.
TI Hydroxyoctadecadienoic acids: Oxidised derivatives of linoleic acid and
   their role in inflammation associated with metabolic syndrome and cancer
SO EUROPEAN JOURNAL OF PHARMACOLOGY
LA English
DT Article
DE Linoleic acid; Hydroxyoctadecadienoic acids; Inflammation; Metabolic
   syndrome; Cancer
ID TUMOR-SUPPRESSOR GENE; 13-HYDROXYOCTADECADIENOIC ACID; PPAR-GAMMA;
   FATTY-ACIDS; COLORECTAL-CANCER; ADRENAL-CELLS; 9-HYDROXYOCTADECADIENOIC
   ACID; 15-LIPOXYGENASE-1 EXPRESSION; ALDOSTERONE SECRETION;
   OXIDATIVE-METABOLISM
AB Linoleic acid (LA) is a major constituent of low-density lipoproteins. An essential fatty acid, LA is a polyunsaturated fatty acid, which is oxidised by endogenous enzymes and reactive oxygen species in the circulation. Increased levels of low-density lipoproteins coupled with oxidative stress and lack of antioxidants drive the oxidative processes. This results in synthesis of a range of oxidised derivatives, which play a vital role in regulation of inflammatory processes. The derivatives of LA include, hydroxyoctadecadienoic acids, oxo-octadecadienoic acids, epoxy octadecadecenoic acid and epoxy-keto-octadecenoic acids. In this review, we examine the role of LA derivatives and their actions on regulation of inflammation relevant to metabolic processes associated with atherogenesis and cancer. The processes affected by LA derivatives include, alteration of airway smooth muscles and vascular wall, affecting sensitivity to pain, and regulating endogenous steroid hormones associated with metabolic syndrome. LA derivatives alter cell adhesion molecules, this initial step, is pivotal in regulating inflammatory processes involving transcription factor peroxisome proliferator-activated receptor pathways, thus, leading to alteration of metabolic processes. The derivatives are known to elicit pleiotropic effects that are either beneficial or detrimental in nature hence making it difficult to determine the exact role of these derivatives in the progress of an assumed target disorder. The key may lie in understanding the role of these derivatives at various stages of development of a disorder. Novel pharmacological approaches in altering the synthesis or introduction of synthesised LA derivatives could possibly help drive processes that could regulate inflammation in a beneficial manner.
   Chemical Compounds: Linoleic acid (PubChem CID: 5280450), 9-hydroxyoctadecadienoic acid (PubChem CID: 5312830), 13-hydroxyoctadecadienoic acid (PubChem CID: 6443013), 9-oxo-octadecadienoic acid (PubChem CID: 3083831), 13-oxo-octadecadienoic acid (PubChem CID: 4163990), 9,10-epoxy-12-octadecenoate (PubChem CID: 5283018), 12,13-epoxy-9-keto-10-trans-octadecenoic acid (PubChem CID: 53394018), Pioglitazone (PubChem CID: 4829). (C) 2015 Elsevier B.V. All rights reserved.
C1 [Vangaveti, Venkat N.; Jansen, Holger; Malabu, Usman H.] James Cook Univ, Coll Med & Dent, Townsville, Qld 4811, Australia.
   [Kennedy, Richard Lee] Deakin Univ, Fac Hlth, Waurn Ponds Campus, Geelong, Vic 3220, Australia.
   [Malabu, Usman H.] Townsville Hosp, Dept Endocrinol & Diabet, 100 Angus Smith Dr, Townsville, Qld 4814, Australia.
C3 James Cook University; Deakin University; Queensland Health; Townsville
   Hospital
RP Vangaveti, VN (corresponding author), James Cook Univ, Coll Med & Dent, Room 109A,Bldg 47, Townsville, Qld 4814, Australia.
EM venkat.vangaveti@jcu.edu.au
RI Vangaveti, Venkat/H-6809-2019; Malabu, Usman Hammawa/K-2055-2013
OI Malabu, Usman Hammawa/0000-0003-4899-7228
FU James Cook University, Queensland, Australia; Private Practice Fund of
   the Townsville Hospital, Queensland, Australia
FX We thank James Cook University, Queensland, Australia and the Private
   Practice Fund of the Townsville Hospital, Queensland, Australia for
   generously supporting this work.
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NR 68
TC 115
Z9 124
U1 1
U2 31
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0014-2999
EI 1879-0712
J9 EUR J PHARMACOL
JI Eur. J. Pharmacol.
PD AUG 15
PY 2016
VL 785
BP 70
EP 76
DI 10.1016/j.ejphar.2015.03.096
PG 7
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA DS4LP
UT WOS:000380752900010
PM 25987423
DA 2025-06-11
ER

PT J
AU Lavie, L
   Polotsky, V
AF Lavie, Lena
   Polotsky, Vsevolod
TI Cardiovascular Aspects in Obstructive Sleep Apnea Syndrome - Molecular
   Issues, Hypoxia and Cytokine Profiles
SO RESPIRATION
LA English
DT Review
DE Cardiovascular morbidity; Cytokines; Inflammation; Obstructive sleep
   apnea; Oxidative stress
ID CHRONIC INTERMITTENT HYPOXIA; POSITIVE AIRWAY PRESSURE;
   CORONARY-ARTERY-DISEASE; NECROSIS-FACTOR-ALPHA; C-REACTIVE PROTEIN;
   FACTOR-KAPPA-B; INTIMA-MEDIA THICKNESS; E-KNOCKOUT MICE; OXIDATIVE
   STRESS; INSULIN-RESISTANCE
AB Obstructive sleep apnea syndrome (OSAS), which is a highly prevalent breathing disorder in sleep, is an independent risk factor for cardiovascular morbidity and mortality. Results from clinical studies as well as animal models and cell culture studies utilizing intermittent hypoxia implicate oxidative stress and inflammation in the pathogenesis of OSAS. However, the underlying mechanisms are not entirely understood. Both oxidative stress and inflammation are major components in the initiation and development of endothelial dysfunction and consequently atherosclerosis. Yet, these fundamental mechanisms are associated with obesity and with components of the metabolic syndrome that also cluster with OSAS. Accumulated evidence indicates that inflammatory cytokines such as TNF-alpha that are under the control of nuclear factor kappa B actively participate in endothelial damage. The current review highlights some of the recent findings on oxidative stress and inflammation in OSAS with specific emphasis on the role of inflammatory pathway activation and expression of cytokines and their possible role in OSAS-related cardiovascular morbidity. In light of the new findings in the field of cytokines, their potential involvement in endothelial dysfunction and cardiovascular morbidity in OSAS is discussed. Copyright (C) 2009 S. Karger AG, Basel
C1 [Lavie, Lena] Technion Israel Inst Technol, Bruce Rappaport Fac Med, Unit Anat & Cell Biol, Lloyd Rigler Sleep Apnea Res Lab, IL-31096 Haifa, Israel.
   [Polotsky, Vsevolod] Johns Hopkins Univ, Sch Med, Div Pulm & Crit Care Med, Johns Hopkins Asthma & Allergy Ctr, Baltimore, MD USA.
C3 Technion Israel Institute of Technology; Rappaport Faculty of Medicine;
   Johns Hopkins University; Johns Hopkins Medicine
RP Lavie, L (corresponding author), Technion Israel Inst Technol, Ruth & Bruce Rappaport Fac Med, Unit Anat & Cell Biol, POB 9649, IL-31096 Haifa, Israel.
EM lenal@tx.technion.ac.il
RI Lavandero, Sergio/B-6001-2013
FU Binational US-Israel foundation [2009557]
FX This study was supported in part by a grant from the Binational
   US-Israel foundation grant (2009557).
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NR 112
TC 65
Z9 73
U1 1
U2 12
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0025-7931
J9 RESPIRATION
JI Respiration
PY 2009
VL 78
IS 4
BP 361
EP 370
DI 10.1159/000243552
PG 10
WC Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Respiratory System
GA 509NL
UT WOS:000271024600001
PM 19786735
DA 2025-06-11
ER

PT J
AU Ke, ZL
   Zhao, YY
   Tan, S
   Chen, H
   Li, Y
   Zhou, ZQ
   Huang, C
AF Ke, Zunli
   Zhao, Yuanyuan
   Tan, Si
   Chen, Hui
   Li, Yin
   Zhou, Zhiqin
   Huang, Cheng
TI Citrus reticulata Blanco peel extract ameliorates hepatic
   steatosis, oxidative stress and inflammation in HF and MCD diet-induced
   NASH C57BL/6 J mice
SO JOURNAL OF NUTRITIONAL BIOCHEMISTRY
LA English
DT Article
DE Oxidative stress; Inflammation; Lipid deposition; NASH; Citrus
   reticulata Blanco peel extract; Nrf2
ID FATTY LIVER-DISEASE; INSULIN-RESISTANCE; SIGNALING PATHWAY; OBESITY;
   NRF2; FLAVONOIDS; TANGERETIN; NOBILETIN; EPIDEMIOLOGY; METABOLISM
AB Excessive lipid deposition, oxidative stress and inflammation in liver tissues are regarded as crucial inducers of nonalcoholic steatohepatitis (NASH), which is the most frequent chronic liver disease and dosely related to obesity and insulin resistance. In this work, the preventive and therapeutic effects of Citrus reticulata Blanco (Jizigan) peel extract (JZE) on NASH induced by high fat (HF) diet and methionine choline-deficient (MCD) diet in C57BL/6 mice were investigated. We found that daily supplementation of JZE with an HF diet effectively ameliorated glucose tolerance and insulin resistance. In addition, the key indexes of lipid profiles, oxidative stress, hepatic steatosis and inflammatory factors were also ameliorated in both NASH mouse models. Furthermore, JZE treatment activated nuclear factor erythroid-2-related factor 2 (Nrf2) in the livers of diet- induced NASH mice. Our study suggests that JZE might alleviate NASH via the activation of Nrf2 signaling and that citrus Jizigan could be used as a dietary therapy for NASH and related metabolic syndrome. (C) 2020 Elsevier Inc. All rights reserved.
C1 [Ke, Zunli] Guizhou Univ Tradit Chinese Med, Basic Med Sch, Morphol Lab, Guiyang 550025, Guizhou, Peoples R China.
   [Ke, Zunli; Zhao, Yuanyuan; Chen, Hui; Li, Yin; Huang, Cheng] Shanghai Univ Tradit Chinese Med, Sch Pharm, Drug Discovery Lab, Shanghai 201203, Peoples R China.
   [Ke, Zunli; Zhou, Zhiqin] Southwest Univ, Coll Hort & Landscape Architecture, Chongqing 400716, Peoples R China.
   [Tan, Si] Yangtze Normal Univ, Sch Adv Agr & Bioengn, Chongqing 408100, Peoples R China.
   [Zhao, Yuanyuan] Zhejiang Univ, Sch Publ Hlth, Inst Environm Hlth, Hangzhou 310058, Peoples R China.
   [Li, Yin] Hebei Radio & TV Univ, Shijiazhuang 050080, Hebei, Peoples R China.
C3 Guizhou University of Traditional Chinese Medicine; Shanghai University
   of Traditional Chinese Medicine; Southwest University - China; Yangtze
   Normal University; Zhejiang University
RP Huang, C (corresponding author), Shanghai Univ Tradit Chinese Med, Sch Pharm, Drug Discovery Lab, Shanghai 201203, Peoples R China.
EM chuang@shutcm.edu.cn
RI Zhao, Yuanyuan/AAN-7654-2020
FU Doctoral Fund of Guizhou University of Traditional Chinese Medicine
   [3043-043190028]; Guizhou Academic Talents and Innovative Exploration
   Projects [3040-040190091]; Guizhou Administration of Traditional Chinese
   Medicine Projects [QZYY-2018-111]
FX This work was supported by the Doctoral Fund of Guizhou University of
   Traditional Chinese Medicine (3043-043190028), Guizhou Academic Talents
   and Innovative Exploration Projects (3040-040190091) and Guizhou
   Administration of Traditional Chinese Medicine Projects (QZYY-2018-111).
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NR 59
TC 34
Z9 34
U1 3
U2 48
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0955-2863
EI 1873-4847
J9 J NUTR BIOCHEM
JI J. Nutr. Biochem.
PD SEP
PY 2020
VL 83
AR 108426
DI 10.1016/j.jnutbio.2020.108426
PG 10
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA MW0YR
UT WOS:000556774100011
PM 32559586
DA 2025-06-11
ER

PT J
AU Zhang, Y
   Ding, J
   Guo, HB
   Liu, Z
   Liu, Q
   Li, YS
   Zhang, DZ
   Liang, JY
AF Zhang, Yi
   Ding, Jun
   Guo, Hongbin
   Liu, Ze
   Liu, Qi
   Li, Yusheng
   Zhang, Dianzhong
   Liang, Jieyu
TI Associations of Dietary and Circulating Vitamin E Level With Metabolic
   Syndrome. A Meta-Analysis of Observational Studies
SO FRONTIERS IN NUTRITION
LA English
DT Review
DE dietary vitamin E; circulating vitamin E; metabolic syndrome;
   meta-analysis; observational studies
ID SERUM ANTIOXIDANT CONCENTRATIONS; NATIONAL-HEALTH; DIABETES-MELLITUS; E
   SUPPLEMENTATION; OXIDATIVE STRESS; RISK-FACTOR; PREVALENCE; ADULTS;
   HYPERTENSION; CHOLESTEROL
AB Objective: The associations of dietary and circulating vitamin E level with metabolic syndrome (MetS) remains conflicting. This meta-analysis of observational study was therefore employed to investigate the issue above.Methods: The PubMed, Web of Science and Embase database were searched up to April 2021. The observational studies on the associations of dietary and circulating vitamin E level with MetS were specified. The pooled relative risk (RR) of MetS for the highest vs. lowest dietary and circulating vitamin E level, and the standard mean difference (SMD) of dietary and circulating vitamin E level for MetS vs. control subjects, were calculated.Results: A total of 25 observational studies with 51,276 participants, were included in this meta-analysis. The overall multi-variable adjusted RR demonstrated that the dietary vitamin E level was inversely associated with MetS (RR = 0.92, 95%CI: 0.85-1.00; P = 0.044). In addition, the dietary vitamin E level in MetS was also lower than that in control subjects according to the overall combined SMD (SMD = -0.08, 95%CI: -0.14 to -0.02; P = 0.024). On the other hand, the overall multi-variable adjusted RR showed no significant relationship between the circulating vitamin E level and MetS (RR = 1.46, 95%CI: 0.85-2.48; P = 0.17). However, the circulating vitamin E level in MetS was lower than that in control subjects according to the overall combined SMD (SMD = -0.58, 95%CI: -1.04 to -0.13; P = 0.013).Conclusions: The results of this meta-analysis suggest that the dietary vitamin E level is inversely associated with MetS. On the other hand, current evidence is still insufficient to conclude a relationship between the circulating vitamin E level and MetS. More well-designed prospective cohort studies are needed to address the issues further.
C1 [Zhang, Yi; Guo, Hongbin; Liu, Ze; Liu, Qi; Li, Yusheng; Liang, Jieyu] Cent South Univ, Xiangya Hosp, Dept Orthopaed, Changsha, Peoples R China.
   [Zhang, Yi; Guo, Hongbin; Li, Yusheng; Liang, Jieyu] Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha, Peoples R China.
   [Ding, Jun] Changsha Social Work Coll, Changsha, Peoples R China.
   [Zhang, Dianzhong] Cent South Univ, Sch Math & Stat, Ctr Teaching & Res Adv Math, Changsha, Peoples R China.
C3 Central South University; Central South University; Changsha Social Work
   College; Central South University
RP Liang, JY (corresponding author), Cent South Univ, Xiangya Hosp, Dept Orthopaed, Changsha, Peoples R China.; Liang, JY (corresponding author), Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha, Peoples R China.; Zhang, DZ (corresponding author), Cent South Univ, Sch Math & Stat, Ctr Teaching & Res Adv Math, Changsha, Peoples R China.
EM zdz1962@163.com; jamesliang8@aliyun.com
RI Zhang, Yi/U-8628-2017; 梁, 捷予/GQH-8556-2022; Guo, Hongbin/ABA-7900-2021;
   Ding, Jun/ABH-1012-2021
FU National Natural Science Foundation of China [82102581]; National
   Postdoctoral Science Foundation of China [2021M693562]; Provincial
   Outstanding Postdoctoral Innovative Talents Program of Hunan
   [2021RC2020]; Provincial Natural Science Foundation of Hunan
   [2019JJ40517]; Xiangya Hospital, Central South University [2020Q14];
   FuQing Postdoc Program of Xiangya Hospital, Central South University
   [176]
FX This study was supported by National Natural Science Foundation of China
   (82102581), National Postdoctoral Science Foundation of China
   (2021M693562), Provincial Outstanding Postdoctoral Innovative Talents
   Program of Hunan (2021RC2020), Provincial Natural Science Foundation of
   Hunan (2019JJ40517), Young Investigator Grant of Xiangya Hospital,
   Central South University (2020Q14), and FuQing Postdoc Program of
   Xiangya Hospital, Central South University (176).
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NR 64
TC 13
Z9 13
U1 0
U2 5
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD DEC 8
PY 2021
VL 8
AR 783990
DI 10.3389/fnut.2021.783990
PG 16
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA XS6CE
UT WOS:000732993700001
PM 34957185
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Marseglia, L
   Manti, S
   D'Angelo, G
   Nicotera, A
   Parisi, E
   Di Rosa, G
   Gitto, E
   Arrigo, T
AF Marseglia, Lucia
   Manti, Sara
   D'Angelo, Gabriella
   Nicotera, Antonio
   Parisi, Eleonora
   Di Rosa, Gabriella
   Gitto, Eloisa
   Arrigo, Teresa
TI Oxidative Stress in Obesity: A Critical Component in Human Diseases
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE obesity; oxidative stress; adipocytokines; human diseases; adipose
   tissue
ID PLASMINOGEN-ACTIVATOR INHIBITOR-1; KAPPA-B ACTIVATION;
   NECROSIS-FACTOR-ALPHA; BODY-MASS INDEX; INSULIN-RESISTANCE; NONALCOHOLIC
   STEATOHEPATITIS; ENDOTHELIAL-CELLS; ADIPOSE-TISSUE; ADHESION MOLECULES;
   LIPID-PEROXIDATION
AB Obesity, a social problem worldwide, is characterized by an increase in body weight that results in excessive fat accumulation. Obesity is a major cause of morbidity and mortality and leads to several diseases, including metabolic syndrome, diabetes mellitus, cardiovascular, fatty liver diseases, and cancer. Growing evidence allows us to understand the critical role of adipose tissue in controlling the physic-pathological mechanisms of obesity and related comorbidities. Recently, adipose tissue, especially in the visceral compartment, has been considered not only as a simple energy depository tissue, but also as an active endocrine organ releasing a variety of biologically active molecules known as adipocytokines or adipokines. Based on the complex interplay between adipokines, obesity is also characterized by chronic low grade inflammation with permanently increased oxidative stress (OS). Over-expression of oxidative stress damages cellular structures together with under-production of anti-oxidant mechanisms, leading to the development of obesity-related complications. The aim of this review is to summarize what is known in the relationship between OS in obesity and obesity-related diseases.
C1 [Marseglia, Lucia; D'Angelo, Gabriella; Gitto, Eloisa] Univ Messina, Dept Pediat, Neonatal & Pediat Intens Care Unit, I-98125 Messina, Italy.
   [Manti, Sara; Arrigo, Teresa] Univ Messina, Dept Paediat, Unit Paediat Genet & Immunol, I-98125 Messina, Italy.
   [Nicotera, Antonio; Parisi, Eleonora; Di Rosa, Gabriella] Univ Messina, Dept Pediat, Unit Child Neurol & Psychiat, I-98125 Messina, Italy.
C3 University of Messina; University of Messina; University of Messina
RP Marseglia, L (corresponding author), Univ Messina, Dept Pediat, Neonatal & Pediat Intens Care Unit, Via Consolare Valeria 1, I-98125 Messina, Italy.
EM lmarseglia@unime.it; saramanti@hotmail.it; gabridangelo@alice.it;
   antonionicotera@ymail.com; leluccia83@hotmail.it; gdirosa@unime.it;
   egitto@unime.it; tarrigo@unime.it
RI gitto, eloisa/AAC-3956-2022; Di Rosa, Gabriella/ABE-8759-2020; Nicotera,
   Antonio Gennaro/AAF-1781-2019
OI Gitto, Eloisa/0000-0001-7442-8630; Nicotera, Antonio
   Gennaro/0000-0002-0847-2243; Scientifica, Direzione/0000-0002-1133-9355;
   Manti, Sara/0000-0002-7664-3083
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NR 154
TC 682
Z9 742
U1 5
U2 101
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD JAN
PY 2015
VL 16
IS 1
BP 378
EP 400
DI 10.3390/ijms16010378
PG 23
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA AZ7MN
UT WOS:000348403100021
PM 25548896
OA gold, Green Published, Green Submitted
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Nurtazina, A
   Voitsekhovskiy, I
   Toishimanov, M
   Dautov, D
   Karibayev, K
   Smail, Y
   Rakhyzhanova, S
   Adilgozhina, S
   Kanapiyanov, B
   Myrzabayeva, N
   Bapayeva, M
   Dyussupov, A
AF Nurtazina, Alma
   Voitsekhovskiy, Ivan
   Toishimanov, Maxat
   Dautov, Daulet
   Karibayev, Kairat
   Smail, Yerbol
   Rakhyzhanova, Saule
   Adilgozhina, Saltanat
   Kanapiyanov, Bakyt
   Myrzabayeva, Nurgul
   Bapayeva, Magripa
   Dyussupov, Altay
TI Exploring the Link Between Vitamin B Levels and Metabolic Syndrome Risk:
   Insights from a Case-Control Study in Kazakhstan
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Article
DE metabolic syndrome; serum levels of vitamins B; Kazakh population
ID CARDIOVASCULAR-DISEASE; RIBOFLAVIN DEFICIENCY; STRESS; PLASMA; WOMEN
AB Background/Objectives: Metabolic syndrome (MS) is a collection of metabolic disorders that include insulin resistance, central obesity, dyslipidemia, and hypertension. The prevalence of MS affects 20-30% of adults worldwide, leading to serious health, social, and economic issues. Mitochondrial dysfunction, characterized by mitochondrial DNA (mtDNA) mutations and altered dynamics, plays a pivotal role in MS by impairing glucose oxidation. B vitamins are crucial for optimal mitochondrial function and overall metabolic processes, particularly within the context of MS. This study aims to investigate the associations between plasma concentrations of B vitamins and the risk of MS within the Kazakh population. Methods: In this case-control study, biochemistry measurements included serum fasting glucose, HbA1c, creatinine, and lipid profile parameters. The sample comprised individuals who agreed to participate in the investigation and at the Semey polyclinic between December 2022 to March 2024. A total of 190 Kazakhs aged 35-65 years old, including 104 subjects with MS and 86 without MS, took part in the study. Results: In a comparative analysis of serum vitamin B levels against established reference ranges, the following results were observed: 95% of participants exhibited vitamin B2 levels at the lower limit of normal, while 4.59% were classified as low. For vitamin B3, 95.77% showed low levels, with only 4.23% in the normal range. Vitamin B6 levels were low in 76.02% of participants. In contrast, 92.82% had normal serum levels of vitamin B9. Regarding vitamin B12, 38.82% had normal levels, 59.41% had elevated levels, and 1.76% were classified as low. Among the evaluated vitamins, only vitamin B2 showed a significant correlation with the risk of developing MS, with an OR of 1.79 (95% CI 1.003, 3.19, p = 0.05). Conclusions: Relatively elevated serum levels of vitamin B2 at the lower limit of the normal range are associated with a 1.8-fold increased risk of developing MS.
C1 [Nurtazina, Alma] Semey Med Univ, Dept Epidemiol & Biostat, Semey 071400, Kazakhstan.
   [Nurtazina, Alma] Semey Med Univ, Dept Internal Med, Semey 071400, Kazakhstan.
   [Voitsekhovskiy, Ivan] Al Farabi Kazakh Natl Univ, Fac Biol & Biotechnol, Alma Ata 050040, Kazakhstan.
   [Toishimanov, Maxat; Myrzabayeva, Nurgul] Kazakh Natl Agrarian Res Univ, Kazakhstan Japan Innovat Ctr, Alma Ata, Kazakhstan.
   [Dautov, Daulet] Asfendiyarov Kazakh Natl Med Univ, Dept Dermatovenereol, Alma Ata 050000, Kazakhstan.
   [Karibayev, Kairat] KIMEP, Alma Ata, Kazakhstan.
   [Smail, Yerbol] Semey State Med Univ, Dept Infect Dis & Immunol, Semey, Kazakhstan.
   [Rakhyzhanova, Saule] Semey Med Univ, Dept Physiol Disciplines, Semey 071400, Kazakhstan.
   [Adilgozhina, Saltanat] Semey Med Univ, Dept Gen Med Practice, Semey 071400, Kazakhstan.
   [Kanapiyanov, Bakyt] Semey Med Univ, Dept Propaedeut Internal Dis, Semey, Kazakhstan.
   [Bapayeva, Magripa] KIMEP, Alma Ata, Kazakhstan.
   [Dyussupov, Altay] Semey Med Univ, Rector Off, Semey 071400, Kazakhstan.
C3 Semey State Medical University; Semey State Medical University;
   Al-Farabi Kazakh National University; Kazakh National Agrarian Research
   University; Asfendiyarov Kazakh National Medical University; KIMEP
   University; Semey State Medical University; Semey State Medical
   University; Semey State Medical University; Semey State Medical
   University; KIMEP University; Semey State Medical University
RP Voitsekhovskiy, I (corresponding author), Al Farabi Kazakh Natl Univ, Fac Biol & Biotechnol, Alma Ata 050040, Kazakhstan.
EM alma.nurtazina@smu.edu.kz; ivan.voitsekhovskiy@smu.edu.kz;
   maxat.toishimanov@gmail.com; dautov.d@kaznmu.kz; karibayev@ckb.kz;
   erbol.smail@smu.edu.kz; saule.rakhyzhanova@smu.edu.kz;
   saltanat.adilgozhina@smu.edu.kz; bakyt.kanapiyanov@smu.edu.kz;
   nurgul.myrzabayeva@kaznaru.edu.kz; info@pervaya.kz;
   altaidusupov@gmail.com
RI Toishimanov, Maxat/AGC-4729-2022; Nurtazina, Alma/AAZ-1614-2020
OI Nurtazina, Alma/0009-0001-2904-6083; Kanapiyanov,
   Bakyt/0000-0002-5457-8583; Toishimanov, Maxat/0000-0002-6070-4574
FU Science Committee of the Ministry of Education and Science of the
   Republic of Kazakhstan;  [AP14871855]
FX This research was funded by the Science Committee of the Ministry of
   Education and Science of the Republic of Kazakhstan (grant AP14871855).
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NR 54
TC 1
Z9 1
U1 3
U2 3
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD DEC
PY 2024
VL 13
IS 23
AR 7206
DI 10.3390/jcm13237206
PG 17
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA P2W4K
UT WOS:001376574700001
PM 39685664
OA gold
DA 2025-06-11
ER

PT J
AU Koo, YS
   Lee, YJ
   Park, JM
AF Koo, Ye-Seul
   Lee, Yong-Jae
   Park, Jae-Min
TI Inverse Association of Serum Folate Level with Metabolic Syndrome and
   Its Components in Korean Premenopausal Women: Findings of the 2016-2018
   Korean National Health Nutrition Examination Survey
SO NUTRIENTS
LA English
DT Article
DE folate; metabolic syndrome; premenopause; women
ID INSULIN-RESISTANCE; BLOOD-PRESSURE; CARDIOVASCULAR-DISEASE; OXIDATIVE
   STRESS; DNA METHYLATION; OBESITY; CANCER; HOMOCYSTEINE; INFLAMMATION;
   METAANALYSIS
AB Research on the association of serum folate levels with metabolic syndrome (MetS) in premenopausal women is lacking. This study was aimed to investigate this association in 1730 premenopausal women using the 2016 to 2018 Korean National Health and Nutrition Examination Survey data. Participants' mean age and BMI were 35.9 years and 22.7 kg/m(2), respectively. Participants were divided into three groups according to serum folate tertiles. Odds ratios (OR) and 95% confidence intervals (CIs) for abdominal obesity, elevated blood pressure (BP), high fasting plasma glucose (FPG), high triglycerides (TG), low high-density lipoprotein cholesterol (HDL-C), and MetS were calculated in multiple logistic regression models adjusted for possible confounders, by serum folate level tertiles. Prevalence of MetS (14.9, 11.0, and 8.6%); abdominal obesity (17.8, 16.0, and 11.4%); high TG (17.5, 14.0, and 11.1%); and low HDL-C (50.3, 44.6, and 42.5%) decreased with increasing folate level tertile. Prevalence of elevated BP (14.3, 12.0, and 11.7%) and high FPG (11.9, 15.8, and 13.0%) showed no significant differences according to serum folate level tertiles. The multivariate-adjusted ORs (95% CIs) for MetS, abdominal obesity, elevated BP, high TG, and low HDL-C in the highest folate level tertile were 2.17 (1.46-3.22), 1.80 (1.25-2.60), 1.77 (1.16-2.70), 1.90 (1.35-2.67), and 1.49 (1.14-1.94), respectively. The ORs for high FPG did not show significant differences according to serum folate level tertiles. In conclusion, serum folate levels were inversely associated with an increased risk of MetS in Korean premenopausal women. These results suggest that MetS can be prevented and managed by improving the serum folate levels in premenopausal women.
C1 [Koo, Ye-Seul; Lee, Yong-Jae; Park, Jae-Min] Yonsei Univ, Gangnam Severance Hosp, Coll Med, Dept Family Med, 211 Eonju Ro, Seoul 06273, South Korea.
   [Park, Jae-Min] Yonsei Univ, Grad Sch Med, Dept Med, 50-1 Yonsei Ro, Seoul 03722, South Korea.
C3 Yonsei University; Yonsei University Health System; Yonsei University
RP Park, JM (corresponding author), Yonsei Univ, Gangnam Severance Hosp, Coll Med, Dept Family Med, 211 Eonju Ro, Seoul 06273, South Korea.; Park, JM (corresponding author), Yonsei Univ, Grad Sch Med, Dept Med, 50-1 Yonsei Ro, Seoul 03722, South Korea.
EM rndptmfrnd@yuhs.ac; ukyjhome@yuhs.ac; milkcandy@yuhs.ac
RI Lee, Yong Jae/GLR-4153-2022; Park, JaeMin/ABG-2197-2021
OI Lee, Yong-Jae/0000-0002-6697-476X; Park, JaeMin/0000-0001-8873-8832
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U1 0
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PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD FEB
PY 2022
VL 14
IS 4
AR 880
DI 10.3390/nu14040880
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA ZJ8VY
UT WOS:000762580400001
PM 35215533
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Ye, WL
   Chen, ZX
   Xie, YQ
   Kong, ML
   Li, QQ
   Yu, S
   Chu, C
   Dong, GH
   Zeng, XW
AF Ye, Wan-Lin
   Chen, Zan-Xiong
   Xie, Yan-Qi
   Kong, Min-Li
   Li, Qing-Qing
   Yu, Shu
   Chu, Chu
   Dong, Guang-Hui
   Zeng, Xiao-Wen
TI Associations between serum isomers of perfluoroalkyl acids and metabolic
   syndrome in adults: Isomers of C8 Health Project in China
SO ENVIRONMENTAL RESEARCH
LA English
DT Article
DE Perfluoroalkyl acids; Metabolic syndrome; Adult; Isomers of C8 health
   project in China
ID POLYFLUOROALKYL SUBSTANCES PFASS; PERFLUOROOCTANE SULFONATE PFOS;
   GLUCOSE-HOMEOSTASIS; PERFLUORINATED CHEMICALS; OXIDATIVE STRESS;
   BLOOD-PRESSURE; EXPOSURE; LIPIDS; ACTIVATION; RISK
AB Background: Exposure to perfluoroalkyl acids (PFAAs) is known to be associated with metabolic disorders. However, whether PFAAs isomers are associated with metabolic syndrome (MetS) still remains unknown.
   Objectives: To explore the associations between serum PFAAs isomers and MetS.
   Methods: We recruited 1,501 adults from a cross-sectional study, the ?Isomers of C8 Health Project in China? to investigate the associations between PFAAs isomers and MetS. A total of 20 PFAAs including the isomers of PFOS and PFOA were detected. Logistic regression models and restricted cubic spline models were used to evaluate the relationship of serum PFAAs isomers exposure with MetS and its components as well after adjusting for covariates.
   Results: The MetS prevalence in our study was 43.0%. The serum levels of both PFOS and PFOA isomers were higher in participants with MetS than that with non-MetS (p < 0.05). We found positive associations for per natural log-transformed ng/mL of branched perfluorooctane sulfonate (br-PFOS) (odds ratio (OR) = 1.18, 95% confidence interval (CI): 1.01, 1.38)) linear perfluoronanoic acid (n-PFOA) (OR = 1.35, 95% CI: 1.16, 1.58) and perfluoro-6-methylpheptanoic acid (6 m-PFOA) (OR = 1.32, 95% CI: 1.11, 1.57) with higher odds of MetS after covariates adjustment, while null association was observed for linear isomers of PFOS (OR = 1.09, 95% CI: 0.94, 1.25). We found a nonlinear dose-response relationship with a ?threshold? effect in serum br-PFOS isomers with MetS, in which the odds of MetS increased quickly with increasing serum br-PFOS isomers under low exposure (p for nonlinearity = 0.030).
   Conclusion: We report new evidence of associations between PFAAs isomers and MetS and the nonlinearity of dose-response relationship with br-PFOS isomers. Our findings indicate that more attention is needed to pay on the nonlinearity of dose-response relationship when investigate the association of PFAAs isomers with human health.
C1 [Ye, Wan-Lin; Li, Qing-Qing; Yu, Shu; Chu, Chu; Dong, Guang-Hui; Zeng, Xiao-Wen] Sun Yat Sen Univ, Sch Publ Hlth, Dept Occupat & Environm Hlth, 74 Zhongshan 2nd Rd, Guangzhou 510080, Guangdong, Peoples R China.
   [Chen, Zan-Xiong; Xie, Yan-Qi; Kong, Min-Li] Maternal & Child Hlth Hosp Maoming City, Maoming 525000, Guangdong, Peoples R China.
C3 Sun Yat Sen University
RP Zeng, XW (corresponding author), Sun Yat Sen Univ, Sch Publ Hlth, Dept Occupat & Environm Hlth, 74 Zhongshan 2nd Rd, Guangzhou 510080, Guangdong, Peoples R China.
EM zxw63@mail.sysu.edu.cn
RI Chu, Chu/T-6038-2019; Dong, Guanghui/AAN-4630-2020
FU National Natural Science Foundation of China [81673127, 81950410633,
   81872582, 81872583]; Science and Technology Program of Guangzhou
   [201807010032, 201803010054]; National Key Research and Development
   Program of China [2018YFE0106900, 2018YFC1004300]; Guangdong Provincial
   Natural Science Foundation Team Project [2018B030312005]; Fundamental
   Research Funds for the Central Universities [19ykjc01]; Natural Science
   Foundation of Guangdong Province [2020A1515011131, 2019A050510017,
   2018B05052007, 2017A090905042]
FX This work was supported by the National Natural Science Foundation of
   China (81673127, 81950410633, 81872582, 81872583), the Science and
   Technology Program of Guangzhou (201807010032, 201803010054), National
   Key Research and Development Program of China (2018YFE0106900,
   2018YFC1004300), Guangdong Provincial Natural Science Foundation Team
   Project (2018B030312005), Fundamental Research Funds for the Central
   Universities (19ykjc01), and Natural Science Foundation of Guangdong
   Province (2020A1515011131, 2019A050510017, 2018B05052007,
   2017A090905042). The above funding has not taken control of the study
   design. We are grateful to all participants involving this project. The
   views expressed in this manuscript belong to the authors only.
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NR 92
TC 14
Z9 15
U1 3
U2 46
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0013-9351
EI 1096-0953
J9 ENVIRON RES
JI Environ. Res.
PD MAY
PY 2021
VL 196
AR 110430
DI 10.1016/j.envres.2020.110430
EA MAY 2021
PG 9
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA SA9KE
UT WOS:000649620900001
PM 33181135
DA 2025-06-11
ER

PT J
AU Monda, V
   Sessa, F
   Ruberto, M
   Carotenuto, M
   Marsala, G
   Monda, M
   Cambria, MT
   Astuto, M
   Distefano, A
   Messina, G
AF Monda, Vincenzo
   Sessa, Francesco
   Ruberto, Maria
   Carotenuto, Marco
   Marsala, Gabriella
   Monda, Marcellino
   Cambria, Maria Teresa
   Astuto, Marinella
   Distefano, Alfio
   Messina, Giovanni
TI Aerobic Exercise and Metabolic Syndrome: The Role of Sympathetic
   Activity and the Redox System
SO DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
LA English
DT Article
DE metabolic syndrome; MetS; Orexin A; body mass index; BMI; heart rate;
   HR; cholesterol; physical activity
ID HEART-RATE-VARIABILITY; OXIDATIVE STRESS; PHYSICAL-ACTIVITY;
   CARDIOVASCULAR-DISEASE; OREXIN SYSTEM; OBESITY; REHABILITATION;
   DEFINITION; RESISTANCE; NUTRITION
AB Background: Aerobic exercise can greatly assist in reducing collateral effects of metabolic syndrome (MetS). Moreover, aerobic exercise is associated with sympathetic activation and adaptive responses to sustain muscle engagement, changes in the release of Orexin A, a pleiotropic neuropeptide.
   Aim: The aim of this study was to analyze the beneficial effects of aerobic exercise without dietary changes, in a cohort of MetS subjects, focusing on the role of sympathetic and orexinergic activity. Several blood parameters linked to MetS ROS production, heart rate, galvanic skin response, d-ROM test, and Orexin A serum levels were evaluated in ten males with MetS (BMI 30-34.9) before and after a period of 6 months of aerobic exercise compared to ten healthy subjects.
   Methods: Ten male subjects (aged 54 +/- 4.16) with MetS (MetS group) and ten healthy males (aged 49.7 +/- 2.79, Healthy group) were told about the study protocol and possible risks, signed the informed consent, and voluntarily participated in the study. Several blood parameters were evaluated in the two tested groups and were re-evaluated in the MetS group after 6 months of training (MetS6M group). The training protocol consisted of more than 30 min/day of walking (average speed of 4.5 km/h) and 3 days/week of aerobic activities (jogging under heart rate control - 120-140 bpm for 45 min).
   Results: The results showed that exercise induced a significant increase in GSR and plasma Orexin A but no significant increase in d-ROM values. Significant decreases in the serum ALT enzyme, triglycerides, and total cholesterol were found, while the HDL levels were significantly higher. Finally, a significant reduction of BMI and resting HR were reported.
   Conclusion: The results of this study confirm that physical activity is associated with sympathetic activation, having a pivotal role against adverse effects linked to MetS. Moreover, this study demonstrates that, in patients with MetS, Orexin A is involved in hormonal adaptations to exercise.
C1 [Monda, Vincenzo; Monda, Marcellino] Univ Campania Luigi Vanvitelli, Dept Expt Med, I-81100 Caserta, Italy.
   [Sessa, Francesco; Messina, Giovanni] Univ Foggia, Dept Clin & Expt Med, I-71121 Foggia, Italy.
   [Ruberto, Maria] CDR Santa Maria del Pozzo, I-80049 Naples, Italy.
   [Carotenuto, Marco] Univ Campania Luigi Vanvitelli, Dept Mental Hlth Phys & Prevent Med, Clin Child & Adolescent Neuropsychiat, I-81100 Caserta, Italy.
   [Marsala, Gabriella] Azienda Osped Univ, Osped Riuniti Foggia, Struttura Complessa Farm, I-71121 Foggia, Italy.
   [Cambria, Maria Teresa; Distefano, Alfio] Univ Catania, Dept Biomed & Biotechnol Sci, Sect Med Biochem, I-95123 Catania, Italy.
   [Astuto, Marinella] UO Anestesia & Terapia Intens, Azienda Osped Policlin Vittorio Emanuele, I-95123 Catania, Italy.
C3 Universita della Campania Vanvitelli; University of Foggia; Universita
   della Campania Vanvitelli; University of Catania; Azienda Ospedaliera
   Universitaria Policlinico Vittorio Emanuele Presidio Ferraotto
RP Sessa, F (corresponding author), Univ Foggia, Dept Clin & Expt Med, I-71121 Foggia, Italy.
EM francesco.sessa@unifg.it
RI Carotenuto, Marco/E-2575-2012; Astuto, Marinella/AAE-7766-2021; Messina,
   Giovanni/AAE-8668-2022; Ruberto, Maria/AAI-2055-2020; Sessa,
   Francesco/G-1754-2018
OI Ruberto, Maria/0009-0003-9583-9203; Monda,
   Marcellino/0000-0002-7184-218X; Sessa, Francesco/0000-0003-0357-8791
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NR 62
TC 18
Z9 19
U1 0
U2 2
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-7007
J9 DIABET METAB SYND OB
JI Diabetes Metab. Syndr. Obes.
PY 2020
VL 13
BP 2433
EP 2442
DI 10.2147/DMSO.S257687
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA MJ6MZ
UT WOS:000548203300001
PM 32753926
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Kawamoto, R
   Ninomiya, D
   Kasai, Y
   Senzaki, K
   Kusunoki, T
   Ohtsuka, N
   Kumagi, T
AF Kawamoto, R.
   Ninomiya, D.
   Kasai, Y.
   Senzaki, K.
   Kusunoki, T.
   Ohtsuka, N.
   Kumagi, T.
TI Baseline and changes in serum uric acid independently predict 11-year
   incidence of metabolic syndrome among community-dwelling women
SO JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
LA English
DT Article
DE Serum uric acid; Metabolic syndrome; Retrospective cohort study; Women
ID CAROTID ATHEROSCLEROSIS; OXIDATIVE STRESS; JAPANESE; DISEASE; RISK;
   HYPERTENSION; ASSOCIATION; POPULATION; PREVALENCE; WORKERS
AB Metabolic syndrome (MetS) is associated with an increased risk of major cardiovascular events. In women, increased serum uric acid (SUA) levels are associated with MetS and its components. However, whether baseline and changes in SUA predict incidence of MetS and its components remains unclear.
   The subjects comprised 407 women aged 71 +/- 8 years from a rural village. We have identified participants who underwent a similar examination 11 years ago, and examined the relationship between baseline and changes in SUA, and MetS based on the modified criteria of the National Cholesterol Education Program's Adult Treatment Panel (NCEP-ATP) III report.
   Of these subjects, 83 (20.4%) women at baseline and 190 (46.7%) women at follow-up had MetS. Multiple linear regression analysis was performed to evaluate the contribution of each confounding factor for MetS; both baseline and changes in SUA as well as history of cardiovascular disease, low-density lipoprotein cholesterol, and estimated glomerular filtration ratio (eGFR) were independently and significantly associated with the number of MetS components during an 11-year follow-up. The adjusted odds ratios (ORs) (95% confidence interval) for incident MetS across tertiles of baseline SUA and changes in SUA were 1.00, 1.47 (0.82-2.65), and 3.11 (1.66-5.83), and 1.00, 1.88 (1.03-3.40), and 2.49 (1.38-4.47), respectively. In addition, the combined effect between increased baseline and changes in SUA was also a significant and independent determinant for the accumulation of MetS components (F = 20.29, p < 0.001). The ORs for incident MetS were significant only in subjects with age 55 years, decline in eGFR, and no baseline MetS.
   These results suggested that combined assessment of baseline and changes in SUA levels provides increased information for incident MetS, independent of other confounding factors in community-dwelling women.
C1 [Kawamoto, R.; Ninomiya, D.; Senzaki, K.; Kumagi, T.] Ehime Univ, Dept Community Med, Grad Sch Med, Toon City, Ehime 7910295, Japan.
   [Kawamoto, R.; Ninomiya, D.; Kasai, Y.; Senzaki, K.; Kusunoki, T.; Ohtsuka, N.] Seiyo Municipal Nomura Hosp, Dept Internal Med, 9-53 Nomura,Nomura Cho, Seiyo City, Ehime 7971212, Japan.
C3 Ehime University
RP Kawamoto, R (corresponding author), Ehime Univ, Dept Community Med, Grad Sch Med, Toon City, Ehime 7910295, Japan.; Kawamoto, R (corresponding author), Seiyo Municipal Nomura Hosp, Dept Internal Med, 9-53 Nomura,Nomura Cho, Seiyo City, Ehime 7971212, Japan.
EM rykawamo@m.ehime-u.ac.jp; 98065dn@jichi.ac.jp; tbbyw2svgb@yahoo.co.jp;
   p401057b@icloud.com; kusunoki.tomo.mm@ehime-u.ac.jp;
   ohtsukan@hotmail.com; terukuma@m.ehime-u.ac.jp
RI Kumagi, Teru/AAS-7427-2021
OI Kumagi, Teru/0000-0002-2292-7750
FU Foundation for Development of Community
FX This work was supported in part by a grant-in-aid from the Foundation
   for Development of Community (2017). No additional external funding was
   received for this study. The funders had no role in the study design,
   data collection and analysis, decision to publish, or preparation of the
   manuscript.
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NR 37
TC 15
Z9 16
U1 0
U2 8
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1720-8386
J9 J ENDOCRINOL INVEST
JI J. Endocrinol. Invest.
PD AUG
PY 2018
VL 41
IS 8
BP 959
EP 968
DI 10.1007/s40618-017-0822-8
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA GN4NT
UT WOS:000439004400008
PM 29460261
DA 2025-06-11
ER

PT J
AU Panchal, SK
   Poudyal, H
   Brown, L
AF Panchal, Sunil K.
   Poudyal, Hemant
   Brown, Lindsay
TI Quercetin Ameliorates Cardiovascular, Hepatic, and Metabolic Changes in
   Diet-Induced Metabolic Syndrome in Rats
SO JOURNAL OF NUTRITION
LA English
DT Article
ID FATTY LIVER-DISEASE; HIGH-CARBOHYDRATE; OBESITY; INFLAMMATION; FRUCTOSE;
   PATHOPHYSIOLOGY; OVERWEIGHT; FLAVONOIDS; STATEMENT; MARKERS
AB Metabolic syndrome is a risk factor for cardiovascular disease and nonalcoholic fatty liver disease (NAFLD). We investigated the responses to the flavonol, quercetin, in male Wistar rats (8-9 wk old) divided into 4 groups. Two groups were given either a corn starch rich (C) or high-carbohydrate, high-fat (H) diet for 16 wk; the remaining 2 groups were given either a C or H diet for 8 wk followed by supplementation with 0.8 g/kg quercetin in the food for the following 8 wk (CO and HQ, respectively). The H diet contained similar to 68% carbohydrates, mainly as fructose and sucrose, and similar to 24% fat from beef tallow; the C diet contained similar to 68% carbohydrates as polysaccharides and similar to 0.7% fat. Compared with the C rats, the H rats had greater body weight and abdominal obesity, dyslipidemia, higher systolic blood pressure, impaired glucose tolerance, cardiovascular remodeling, and NAFLD. The H rats had lower protein expressions of nuclear factor (erythroid-derived 2)-related factor-2 (Nrf2), heme oxygenase-1 (HO-1), and carnitine palmitoyltransferase 1 (CPT1) with greater expression of NF-kappa B in both the heart and the liver and less expression of caspase-3 in the liver than in C rats. HQ rats had higher expression of Nrf2, HO-1, and CPT1 and lower expression of NF-kappa B than H rats in both the heart and the liver. HQ rats had less abdominal fat and lower systolic blood pressure along with attenuation of changes in structure and function of the heart and the liver compared with H rats, although body weight and dyslipidemia did not differ between the H and HQ rats. Thus, quercetin treatment attenuated most of the symptoms of metabolic syndrome, including abdominal obesity, cardiovascular remodeling, and NAFLD, with the most likely mechanisms being decreases in oxidative stress and inflammation. J. Nutr. 142: 1026-1032, 2012.
C1 [Panchal, Sunil K.; Brown, Lindsay] Univ So Queensland, Dept Biol & Phys Sci, Toowoomba, Qld 4350, Australia.
   [Poudyal, Hemant] Univ Queensland, Sch Biomed Sci, Brisbane, Qld, Australia.
C3 University of Southern Queensland; University of Queensland
RP Brown, L (corresponding author), Univ So Queensland, Dept Biol & Phys Sci, Toowoomba, Qld 4350, Australia.
EM Lindsay.Brown@usq.edu.au
RI Poudyal, Hemant/HOH-9324-2023
OI Panchal, Sunil K/0000-0001-5464-3376
FU Dr. Red Nutraceuticals, Brisbane, Australia; Prince Charles Hospital
   Foundation, Brisbane, Australia
FX Supported by Dr. Red Nutraceuticals, Brisbane, Australia and the Prince
   Charles Hospital Foundation, Brisbane, Australia.
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NR 43
TC 212
Z9 231
U1 1
U2 68
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0022-3166
EI 1541-6100
J9 J NUTR
JI J. Nutr.
PD JUN
PY 2012
VL 142
IS 6
BP 1026
EP 1032
DI 10.3945/jn.111.157263
PG 7
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 946EY
UT WOS:000304335500008
PM 22535755
OA Bronze
DA 2025-06-11
ER

PT J
AU Al-Daghri, NM
   Wani, K
   AlHarthi, H
   Alghamdi, A
   Alnaami, AM
   Yakout, SM
AF Al-Daghri, Nasser M.
   Wani, Kaiser
   AlHarthi, Hind
   Alghamdi, Amani
   Alnaami, Abdullah M.
   Yakout, Sobhy M.
TI Sex-Specific Signature in the Circulating NLRP3 Levels of Saudi Adults
   with Metabolic Syndrome
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Article
DE inflammasome; NLRP3; metabolic syndrome; oxidative stress; inflammatory
   markers
ID INFLAMMASOME; OBESITY; ADIPOSE
AB Recently, inflammasomes such as NLRP3 as cytosolic pattern-recognition receptors have been implicated in the development of inflammation; however, limited investigations report the circulating levels of this protein. The objective, thus, was to investigative circulating NLRP3 levels in Saudi patients with a low-grade inflammatory disorder called metabolic syndrome (MetS). Two hundred Saudi adults aged 30-65, with or without MetS diagnosed on the basis of National Cholesterol Education Programme Adult Treatment Panel III (NCEP ATP III) criteria, were randomly recruited. Five MetS components were established according to the diagnostic criteria in the study subjects. Circulating levels of NLRP3 and known inflammation markers, such as tumor necrosis factor alpha (TNF-alpha), C-reactive protein (CRP) and interleukins (IL-1 beta and IL-18), were measured in the blood samples taken from the study subjects. Gender-based analysis showed a significant elevated circulating levels of NLRP3 in non-MetS men compared to non-MetS females (p < 0.001). Moreover, an increase in circulating levels of NLRP3 with a number of MetS components (p = 0.038) was observed only in females. A significant positive correlation of NLRP3 levels with age (r = 0.20, p = 0.04), BMI (r = 0.32, p < 0.01) and waist (r = 0.24, p = 0.02) and a significant negative correlation between NLRP3 and HDL-cholesterol (r= -0.21, p = 0.03) were also observed in females. Logistic regression analysis also yielded a sex-specific positive association of NLRP3 with MetS in females, with this association influenced mostly by central obesity and dyslipidemia components of MetS. In conclusion, this study suggests a sexual disparity in the circulating levels of NLRP3, with a trend of increasing circulating NLRP3 levels with increasing MetS components observed only in females, influenced mostly by adiposity and dyslipidemia components of MetS. Longitudinal studies with a larger sample size and investigating sex-specific hormones with NLRP3 would be needed to establish a causal relationship of NLRP3 with MetS.
C1 [Al-Daghri, Nasser M.; AlHarthi, Hind; Alghamdi, Amani] King Saud Univ, Coll Sci, Biochem Dept, Riyadh 11451, Saudi Arabia.
   [Al-Daghri, Nasser M.; Wani, Kaiser; Alnaami, Abdullah M.; Yakout, Sobhy M.] King Saud Univ, Coll Sci, Chair Biomarkers Chron Dis, Riyadh 11451, Saudi Arabia.
C3 King Saud University; King Saud University
RP Al-Daghri, NM (corresponding author), King Saud Univ, Coll Sci, Biochem Dept, Riyadh 11451, Saudi Arabia.; Al-Daghri, NM (corresponding author), King Saud Univ, Coll Sci, Chair Biomarkers Chron Dis, Riyadh 11451, Saudi Arabia.
EM ndaghri@ksu.edu.sa; kwani@ksu.edu.sa; hindalharthi1@gmail.com;
   aalghamedi@ksu.edu.sa; aalnaami@ksu.edu.sa; syakout@ksu.edu.sa
RI yakout, sobhy/E-7509-2019; Al-Daghri, Nasser/A-8360-2011; Alnaami,
   Abdullah/LOR-5409-2024; Wani, Kaiser/N-9522-2015; Alghamdi,
   Amani/HIR-6153-2022
OI Al-Daghri, Nasser/0000-0001-5472-1725; Wani, Kaiser/0000-0001-9568-6516;
   Alghamdi, Amani/0000-0002-7251-1972
FU Deanship of Scientific Research, King Saud University, Riyadh, Saudi
   Arabia
FX This work was supported by the Deanship of Scientific Research, King
   Saud University, Riyadh, Saudi Arabia.
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NR 51
TC 8
Z9 8
U1 0
U2 0
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD AUG
PY 2021
VL 10
IS 15
AR 3288
DI 10.3390/jcm10153288
PG 15
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA TW0TM
UT WOS:000682124100001
PM 34362072
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Leahy, J
   Spahis, S
   Bonneil, E
   Garofalo, C
   Grimard, G
   Morel, S
   Laverdière, C
   Krajinovic, M
   Drouin, S
   Delvin, E
   Sinnett, D
   Marcil, V
   Levy, E
AF Leahy, Jade
   Spahis, Schohraya
   Bonneil, Eric
   Garofalo, Carole
   Grimard, Guy
   Morel, Sophia
   Laverdiere, Caroline
   Krajinovic, Maja
   Drouin, Simon
   Delvin, Edgard
   Sinnett, Daniel
   Marcil, Valerie
   Levy, Emile
TI Insight from mitochondrial functions and proteomics to understand
   cardiometabolic disorders in survivors of acute lymphoblastic leukemia
SO METABOLISM-CLINICAL AND EXPERIMENTAL
LA English
DT Article
DE Mitochondria; Metabolic syndrome; Proteomic; Acute lymphoblastic
   leukemia; Cancer; Survivors
ID CARDIOVASCULAR RISK-FACTORS; YOUNG-ADULT SURVIVORS; INSULIN-RESISTANCE;
   OXIDATIVE STRESS; CHILDHOOD; DYSFUNCTION; DAMAGE; PREVENTION; OBESITY;
   DISEASE
AB Background: Childhood acute lymphoblastic leukemia (cALL) is the most prevalent form of cancer in children. Due to advances in treatment and therapy, young cALL subjects now achieve a 90% survival rate. However, this tremendous advance does not come without consequence since similar to 2/3 of cALL survivors are affected by long-term and late, severe complications. Although the metabolic syndrome is a very serious sequel of cALL, the mechanisms remain undefined. It is also surprising to note that the mitochondrion, a central organelle in metabolic functions and the main cellular energy generator, have not yet been explored.
   Objectives: To determine whether cALL survivors exhibit impairments in their mitochondrial functions and proteomic profiling in relationship with metabolic disorders in cALL survivors compared to healthy controls.
   Methods and Results: Anthropometric measures, metabolic characteristics and lipid profiles were assessed, mitochondria isolated from peripheral blood mononuclear cells, and proteomic analyzed. Our data demonstrated that metabolically. Unhealthy survivors exhibited several metabolic syndrome components (e.g. overweight, insulin resistance, dyslipidemia, inflammation) whereas Healthy cALL survivors resemble the Controls. In line with these abnormalities, functional experiments in these subjects revealed a significant decrease in the protein expression of mitochondrial antioxidant superoxide dismutase, PGC1-alpha transcription factor (a key modulator of mitochondrion biogenesis), and an increase in pro-apoptotic cytochrome c. Proteomic analysis of mitochondria by mass spectrometry revealed changes in the regulation of proteins related to inflammation, apoptosis, energy production, redox and antioxidant activity, fatty acid beta-oxidation, protein transport and metabolism, and signalling pathways between groups.
   Conclusions: Through the use of proteomic analysis, our work demonstrated a number of significant alterations in protein expression in mitochondria of cALL survivors, especially the metabolically Unhealthy survivor group. Further investigation of these proteins may help delineate the mechanisms by which mitochondrial dysfunctions exert cardiometabolic derangements in cALL survivors. (C) 2018 Elsevier Inc. All rights reserved.
C1 [Leahy, Jade; Spahis, Schohraya; Garofalo, Carole; Morel, Sophia; Laverdiere, Caroline; Krajinovic, Maja; Drouin, Simon; Delvin, Edgard; Sinnett, Daniel; Marcil, Valerie; Levy, Emile] Univ Montreal, CHU St Justine, Res Ctr, Montreal, PQ, Canada.
   [Leahy, Jade; Spahis, Schohraya; Morel, Sophia; Marcil, Valerie; Levy, Emile] Univ Montreal, Dept Nutr, Montreal, PQ, Canada.
   [Bonneil, Eric] IRIC Univ Montreal, Prote Platform, Montreal, PQ, Canada.
   [Grimard, Guy; Laverdiere, Caroline; Krajinovic, Maja; Sinnett, Daniel] Univ Montreal, Dept Paediat, Montreal, PQ, Canada.
C3 Universite de Montreal; Centre Hospitalier Universitaire Sainte-Justine;
   Universite de Montreal; Universite de Montreal; Universite de Montreal
RP Levy, E (corresponding author), CHU St Justine, GI Nutr Unit, 3175 Ste Catherine Rd,4-17-005, Montreal, PQ H3T 1C5, Canada.
EM emile.levy@recherche-ste-Justine.qc.ca
RI sinnett, daniel/S-4589-2017; Drouin, Simon/O-1683-2019
OI Drouin, Simon/0000-0003-1686-544X
FU Institute of Cancer Research of the Canadian Institutes of Health
   Research; C17 Council; Canadian Cancer Society; Cancer Research Society;
   Garron Family Cancer Centre at the Hospital for Sick Children; Ontario
   Institute for Cancer Research; JA DeSeve Research Chair in Nutrition
FX This work was supported by a grant from the Institute of Cancer Research
   of the Canadian Institutes of Health Research, in collaboration with C17
   Council, Canadian Cancer Society, Cancer Research Society, Garron Family
   Cancer Centre at the Hospital for Sick Children, Ontario Institute for
   Cancer Research, and the JA DeSeve Research Chair in Nutrition.
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NR 45
TC 13
Z9 13
U1 0
U2 6
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0026-0495
EI 1532-8600
J9 METABOLISM
JI Metab.-Clin. Exp.
PD AUG
PY 2018
VL 85
BP 151
EP 160
DI 10.1016/j.metabol.2018.03.011
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA HG1UL
UT WOS:000454746400015
PM 29563052
DA 2025-06-11
ER

PT J
AU Chapman, MJ
   Orsoni, A
   Robillard, P
   Therond, P
   Giral, P
AF Chapman, M. John
   Orsoni, Alexina
   Robillard, Paul
   Therond, Patrice
   Giral, Philippe
TI Duality of statin action on lipoprotein subpopulations in the mixed
   dyslipidemia of metabolic syndrome: Quantity vs quality over time and
   implication of CETP
SO JOURNAL OF CLINICAL LIPIDOLOGY
LA English
DT Article
DE Mixed dyslipidemia; Metabolic syndrome; Low-density lipoprotein; Very
   low-density lipoproteins; Remnants; High-density lipoprotein; CETP;
   Pitavastatin
ID TRIGLYCERIDE-RICH LIPOPROTEINS; HIGH-DENSITY-LIPOPROTEIN; CHOLESTERYL
   ESTER TRANSFER; ELEVATED OXIDATIVE STRESS; APOLIPOPROTEIN-C-III;
   CARDIOVASCULAR-DISEASE; COMBINED HYPERLIPIDEMIA; INSULIN-RESISTANCE;
   TRANSFER PROTEIN; HDL3 PARTICLES
AB BACKGROUND: Statins impact the metabolism, concentrations, composition, and function of circulating lipoproteins.
   OBJECTIVE: We evaluated time course relationships between statin-mediated reduction in atherogenic apolipoprotein B (ApoB) containing particles and dynamic intravascular remodeling of ApoAI-containing lipoprotein subpopulations in the mixed dyslipidemia of metabolic syndrome.
   METHODS: Insulin-resistant, hypertriglyceridemic, hypercholesterolemic, obese males (n = 12) were treated with pitavastatin (4 mg/d) and response evaluated at 6, 42, and 180 days.
   RESULTS: Reduction in low-density lipoprotein (LDL) cholesterol, ApoB, and triglycerides (TGs) was essentially complete at 42 days (-38%, -32%, and -35%, respectively); rapid reduction equally occurred in remnant cholesterol, ApoCII, CIII, and E levels (day 6; -35%, -50%, -23%, and -26%, respectively). Small dense LDLs (LDL4 and LDL5 subpopulations) predominated at baseline and were markedly reduced on treatment (-29% vs total LDL mass). Cholesteryl ester (CE) transfer protein activity and mass decreased progressively (-18% and -16%, respectively); concomitantly, TG depletion (up to -49%) and CE enrichment occurred in all high-density lipoprotein (HDL) particle subpopulations with normalization of CE/TG mass ratio at 180 days. ApoAI was redistributed from LpAI to LpAI:AII particles in HDL2a and HDL3a subpopulations; ApoCIII was preferentially depleted from LpAI:AII-rich particles on treatment.
   CONCLUSION: Overall, statin action exhibits duality in mixed dyslipidemia, as CE transfer protein-mediated normalization of the HDL CE/TG core lags markedly behind subacute reduction in elevated levels of atherogenic ApoB-containing lipoproteins. Normalization of the HDL neutral lipid core is consistent with enhanced atheroprotective function. The HDL CE/TG ratio constitutes a metabolomic marker of perturbed HDL metabolism in insulin-resistant states, equally allowing monitoring of statin impact on HDL metabolism, structure, and function. (C) 2017 National Lipid Association. Published by Elsevier Inc.
C1 [Chapman, M. John; Orsoni, Alexina; Robillard, Paul] Pitie Salpetriere Univ Hosp, INSERM, Natl Inst Hlth & Med Res, Paris, France.
   [Chapman, M. John] Pitie Salpetriere Univ Hosp, Dept Endocrinol Metab, Paris, France.
   [Chapman, M. John] Pierre & Marie Curie Univ Paris 6, Paris, France.
   [Orsoni, Alexina; Therond, Patrice] Bicetre Univ Hosp, HUPS, AP HP, Serv Biochim, Le Kremlin Bicetre, France.
   [Therond, Patrice] Paris Saclay Univ, Chatenay Malabry, France.
   [Therond, Patrice] Paris Sud Univ, EA 7357, Chatenay Malabry, France.
   [Giral, Philippe] Pitie Salpetriere Univ Hosp, AP HP, INSERM UMR1166, Paris, France.
   [Giral, Philippe] Pitie Salpetriere Univ Hosp, AP HP, ICAN Inst CardioMetab & Nutr, Cardiovasc Prevent Units, Paris, France.
C3 Assistance Publique Hopitaux Paris (APHP); Hopital Universitaire
   Pitie-Salpetriere - APHP; Institut National de la Sante et de la
   Recherche Medicale (Inserm); Sorbonne Universite; Assistance Publique
   Hopitaux Paris (APHP); Hopital Universitaire Pitie-Salpetriere - APHP;
   Sorbonne Universite; Sorbonne Universite; Assistance Publique Hopitaux
   Paris (APHP); Hopital Universitaire Bicetre - APHP; Universite Paris
   Saclay; Universite Paris Saclay; Assistance Publique Hopitaux Paris
   (APHP); Hopital Universitaire Pitie-Salpetriere - APHP; Sorbonne
   Universite; Institut National de la Sante et de la Recherche Medicale
   (Inserm); Assistance Publique Hopitaux Paris (APHP); Hopital
   Universitaire Pitie-Salpetriere - APHP; Sorbonne Universite
RP Chapman, MJ (corresponding author), Pitie Salpetriere Univ Hosp, INSERM, 83 Blvd Hop, F-75651 Paris 13, France.; Chapman, MJ (corresponding author), Pitie Salpetriere Univ Hosp, Endocrinol Metab Serv, 83 Blvd Hop, F-75651 Paris 13, France.
EM john.chapman@upmc.fr
RI chapman, john/Y-2742-2019; ORSONI, Alexina/C-6740-2009
FU Kowa Research Europe; Kowa Pharmaceuticals America Inc [NCT01595828]
FX We are indebted to Kowa Research Europe and Kowa Pharmaceuticals America
   Inc for the award of a Clinical Research Grant to support all aspects of
   the CAPITAIN study, (ClinicalTrials.gov: NCT01595828), and to INSERM,
   the NSFA, and ARLA for additional support. The content of this
   manuscript is solely the responsibility of the authors and does not
   necessarily represent the official views of the aforementioned funding
   bodies. The authors take full responsibility for the content of this
   manuscript. No funders or sponsors were involved in the final design and
   conduct of the study; collection, management, analysis, and
   interpretation of the data; preparation, review, or approval of the
   manuscript; or decision to submit the manuscript for publication.
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NR 75
TC 13
Z9 13
U1 0
U2 3
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1933-2874
EI 1876-4789
J9 J CLIN LIPIDOL
JI J. Clin. Lipidol.
PD JUN
PY 2018
VL 12
IS 3
BP 784
EP 800
DI 10.1016/j.jacl.2018.02.001
PG 17
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA GJ5MO
UT WOS:000435425800026
PM 29574070
OA hybrid
DA 2025-06-11
ER

PT J
AU Sharma, T
   Ranawat, P
   Garg, A
   Rastogi, P
   Kaushal, N
AF Sharma, Tanvi
   Ranawat, Pavitra
   Garg, Ayushi
   Rastogi, Pulkit
   Kaushal, Naveen
TI Short-chain fatty acids as a novel intervention for high-fat
   diet-induced metabolic syndrome
SO MOLECULAR AND CELLULAR BIOCHEMISTRY
LA English
DT Article
DE Metabolic syndrome; Short-chain fatty acids; High-fat diet; Gut
   microbiota; Gut dysbiosis
ID GUT MICROBIOTA; OBESITY; LIVER; INFLAMMATION; ASSOCIATION; RATS
AB Metabolic syndrome (MetS) is driven by a complex interplay of genetic, lifestyle, and dietary factors, leading to weight gain, insulin resistance, dyslipidemia, and chronic inflammation. Gut microbiota dysbiosis has been recently recognized as a key contributor to MetS, leading to advancements in gut microbiome-based interventions to improve health outcomes. Considering the unique challenges associated with the use of pre/probiotics, short-chain fatty acids (SCFA), also known as postbiotics, have emerged as promising therapeutic agents due to their role in modulating host metabolism and physiology. Considering this, the aim of the current study was to explore the therapeutic potential of SCFA (butyrate, propionate, and acetate) supplementation against a high-fat diet (HFD)-induced experimental model of MetS in male Wistar rats. Alterations in body weight, lipid profile, histopathology, and adipose tissue accumulation were assessed to establish SCFA-mediated amelioration of experimental MetS. Further, the enzymatic (GPx, Catalase, GR, and GST) and non-enzymatic (LPO, total ROS, and Redox ratio were evaluated. The results indicated that SCFA supplementation could effectively mitigate key features of MetS. A significant reduction in body weight gain and fasting blood glucose levels, along with markedly lowered triglycerides, total cholesterol, and LDL levels, with partial restoration of HDL levels was observed following SCFA supplementation. SCFA administration also attenuated MetS-associated hepatic damage as studied by histopathological investigation and analysis of liver function marker enzyme activities. Such ameliorative effects of SCFA against HFD-induced MetS were owed to potential redox modulation studied using enzymatic and non-enzymatic oxidative stress markers. In conclusion, the study's outcomes show that SCFA supplementation could potentially be used against managing MetS. It underscores the therapeutic potential of SCFA by placing them as a novel gut microbiome-based dietary approach to improve metabolic health and reduce the risk of MetS-associated complications. However, more detailed mechanistic explorations are warranted in the future, leading to their beneficial role in MetS contributing to holistic health outcomes.
C1 [Sharma, Tanvi; Ranawat, Pavitra; Garg, Ayushi; Kaushal, Naveen] Panjab Univ, Dept Biophys, Chandigarh 160014, India.
   [Rastogi, Pulkit] Post Grad Inst Med Educ & Res PGIMER, Dept Hematol, Chandigarh 160012, India.
C3 Panjab University; Post Graduate Institute of Medical Education &
   Research (PGIMER), Chandigarh
RP Kaushal, N (corresponding author), Panjab Univ, Dept Biophys, Chandigarh 160014, India.
EM nkaushal@pu.ac.in
RI RASTOGI, PULKIT/K-4084-2019
FU Panjab University [190-218]; Panjab University PhD funding
FX The authors acknowledge the financial support to Ms. Tanvi Sharma (No.
   190-218/Dean Research) by the Panjab University PhD funding.
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NR 74
TC 0
Z9 0
U1 2
U2 2
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0300-8177
EI 1573-4919
J9 MOL CELL BIOCHEM
JI Mol. Cell. Biochem.
PD MAY
PY 2025
VL 480
IS 5
BP 3169
EP 3184
DI 10.1007/s11010-024-05185-9
EA DEC 2024
PG 16
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA 2EA7I
UT WOS:001381622700001
PM 39709317
DA 2025-06-11
ER

PT J
AU Demirdag, F
   Yavuzer, S
   Cengiz, M
   Yavuzer, H
   Kara, Z
   Ayvaci, A
   Avci, S
   Yürueyen, M
   Uzun, H
   Altiparmak, MR
   Döventas, A
   Erdinçler, DS
AF Demirdag, Filiz
   Yavuzer, Serap
   Cengiz, Mahir
   Yavuzer, Hakan
   Kara, Zehra
   Ayvaci, Adnan
   Avci, Suna
   Yurueyen, Mehmet
   Uzun, Hafize
   Altiparmak, Mehmet Riza
   Doventas, Alper
   Erdincler, Deniz Suna
TI The Role of NF-?B, PPAR-a, and PPAR-? in Older Adults with Metabolic
   Syndrome
SO HORMONE AND METABOLIC RESEARCH
LA English
DT Article
DE aging; metabolic syndrome; inflammation; NF-& kappa;B
ID KAPPA-B; OXIDATIVE STRESS; CYTOKINE PRODUCTION; ADIPOSE-TISSUE;
   ACTIVATION; GAMMA; INFLAMMATION; OBESITY; ALPHA; MECHANISM
AB The etiopathogenesis of metabolic syndrome (MetS) has not been fully understood yet, and chronic low-grade inflammation is thought to be associated with the development of complications related to MetS. We aimed to investigate the role of Nuclear factor Kappa B ( NF-?B ), Peroxisome Proliferator-Activated Receptor- a and ? (PPAR-a, and PPAR-?) which are the main markers of inflammation in older adults with MetS. A total of 269 patients aged=18, 188 patients with MetS who met the diagnostic criteria of the International Diabetes Federation, and 81 controls who applied to geriatrics and general internal medicine outpatient clinics for various reasons were included in the study. Patients were separated into four groups: young with MetS (< 60, n=76), elderly with MetS (=60, n=96), young control (< 60, n=31), elderly controls (=60, n=38). Carotid intima-media thickness (CIMT) and NF-?B , PPAR-a, and PPAR-? plasma levels were measured in all of the participants. Age and sex distribution were similar between MetS and control groups. C-reactive protein (CRP), NF-?B levels (p=0.001) and CIMT (p<0,001) of MetS group were significantly higher than in the control groups. On the other hand, the PPAR-? (p=0.008) and PPAR-a (p=0.003) levels were significantly lower in MetS. ROC analysis revealed that the NF-?B, PPAR-a, and PPAR-? could be used to indicate MetS in younger adults (AUC: 0.735, p<0.000; AUC: 0.653, p=0.003), whereas it could not be an indicator in older adults (AUC: 0.617, p=0.079; AUC:0.530, p=0.613). It seems that these markers have important roles in MetS-related inflammation. In our results, suggest that the indicator feature of NF-?B , PPAR-a and PPAR-? in recognizing MetS in young individuals is lost in older adults with Mets.
C1 [Demirdag, Filiz; Yavuzer, Hakan; Avci, Suna; Yurueyen, Mehmet; Doventas, Alper; Erdincler, Deniz Suna] Istanbul Univ Cerrahpasa, Sch Med, Dept Internal Med, Div Geriatr, Istanbul, Turkiye.
   [Demirdag, Filiz] Istanbul Medeniyet Univ, Sch Med Istanbul, Dept Internal Med, Div Geriatr, Istanbul, Turkiye.
   [Yavuzer, Serap; Cengiz, Mahir] Istanbul Univ Cerrahpasa, Sch Med, Dept Internal Med, Istanbul, Turkiye.
   [Kara, Zehra] Istanbul Univ Cerrahpasa, Sch Med, Dept Internal Med, Div Endocrinol, Istanbul, Turkiye.
   [Ayvaci, Adnan] Istanbul Univ Cerrahpasa, Sch Med, Dept Radiol, Istanbul, Turkiye.
   [Uzun, Hafize] Istanbul Atlas Univ, Sch Med, Dept Biochem, Istanbul, Turkiye.
   [Altiparmak, Mehmet Riza] Istanbul Univ Cerrahpasa, Sch Med, Dept Internal Med, Div Nephrol, Istanbul, Turkiye.
   [Demirdag, Filiz] Istanbul Medeniyet Univ, Internal Med Div Geriatr, Elmalikent Mah Kermes Sok Parkevler Sitesi,C-Blok, Istanbul 34764, Turkiye.
C3 Istanbul University - Cerrahpasa; Istanbul Medeniyet University;
   Istanbul University - Cerrahpasa; Istanbul University - Cerrahpasa;
   Istanbul University - Cerrahpasa; Istanbul Atlas University; Istanbul
   University - Cerrahpasa; Istanbul Medeniyet University
RP Demirdag, F (corresponding author), Istanbul Medeniyet Univ, Internal Med Div Geriatr, Elmalikent Mah Kermes Sok Parkevler Sitesi,C-Blok, Istanbul 34764, Turkiye.
EM filizakcay@gmail.com
RI Altiparmak, Mehmet/AAC-2508-2021; Kara, Zehra/AAS-1141-2021; Yavuzer,
   Hakan/Y-5492-2018; Cengiz, Mahir/A-6417-2019; Şahin Yavuzer,
   Serap/ABH-2784-2021; Demirdağ, Filiz/GQP-0292-2022; Uzun,
   Hafize/D-4811-2019; Cengiz, Mahir/C-4995-2015
OI Cengiz, Mahir/0000-0003-3343-8650; YAVUZER, SERAP/0000-0001-7618-9987
FU Research Fund of Istanbul University [23089]
FX This study was funded by the Research Fund of Istanbul University
   (Project ID: 23089).
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NR 40
TC 3
Z9 3
U1 0
U2 7
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0018-5043
EI 1439-4286
J9 HORM METAB RES
JI Horm. Metab. Res.
PD OCT
PY 2023
VL 55
IS 10
BP 733
EP 740
DI 10.1055/a-2109-1958
EA JUL 2023
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA U2CS7
UT WOS:001032807200001
PM 37308136
DA 2025-06-11
ER

PT J
AU Yin, J
   Lu, JX
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   He, MS
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AF Yin, Jing
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   Lei, Peng
   He, Mingshuai
   Huang, Shengjie
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   Zhu, Yan
   Liu, Zhidong
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TI Danggui-Shaoyao-San Improves Gut Microbia Dysbiosis and Hepatic Lipid
   Homeostasis in Fructose-Fed Rats
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Article
DE Danggui-Shaoyao-San; metabolic syndrome; gut microbiadysbiosis;
   anti-inflammation; hepatic lipid homeostasis
ID DE-NOVO LIPOGENESIS; URIC-ACID; METABOLIC SYNDROME; OXIDATIVE STRESS;
   AKKERMANSIA-MUCINIPHILA; INCREASED EXPRESSION; INSULIN SENSITIVITY;
   CHOLESTEROL; MITOCHONDRIAL; ASSIMILATION
AB Metabolic syndrome (MetS) is a pathological state of many abnormal metabolic sections. These abnormalities are closely related to diabetes, heart pathologies and other vascular diseases. Danggui-Shaoyao-San (DSS) is a traditional Chinese medicine formula that has been used as a therapy for Alzheimer's disease. DSS has rarely been reported in the application of MetS and its mechanism of how it improves gut microbia dysbiosis and hepatic lipid homeostasis. In this study, three extracts of DSS were obtained using water, 50% methanol in water and methanol as extracting solvents. Their chemical substances were analyzed by ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass (UPLC-Q/TOF-MS). Pharmacodynamic effect of the extracts were evaluated by comparison of biochemical factors, 16S rRNA sequencing test for gut microbiota analysis, as well as metabonomic and transcriptomic assessments on liver tissues from fructose-fed rats. This study aimed at investigating DSS's mechanism of regulating blood lipid, anti-inflammation and reducing blood glucose. The results showed that the 50% methanol extract (HME) was more effective. It was worth noting that hydroxysteroid 17 beta-dehydrogenase 13 (HSD17 beta 13) as a critical element of increasing blood lipid biomarker-triglyceride (TG), was decreased markedly by DSS. The influence from upgraded hydroxysteroid 17 beta-dehydrogenase 7 (HSD17 beta 7) may be stronger than that from downgraded Lactobacillus in the aspect of regulating back blood lipid biomarker-total cholesterol (TC). The differential down-regulation of tumornecrosis factor alpha (TNF-alpha) and the significant up-regulation of Akkermansia showed the effective effect of anti-inflammation by DSS. The declining glycine and alanine induced the lowering glucose and lactate. It demonstrated that DSS slowed down the reaction of gluconeogenesis to reduce the blood glucose. The results demonstrated that DSS improved pathological symptoms of MetS and some special biochemical factors in three aspects by better regulating intestinal floras and improving hepatic gene expressions and metabolites.
C1 [Yin, Jing; Lu, Jiaxi; Lei, Peng; He, Mingshuai; Huang, Shengjie; Lv, Jialin; Zhu, Yan; Liu, Zhidong; Jiang, Miaomiao] Tianjin Univ Tradit Chinese Med, State Key Lab Component Based Chinese Med, Tianjin, Peoples R China.
   [Jiang, Miaomiao] Tianjin Univ Tradit Chinese Med, Inst Tradit Chinese Med, Dept Pharm, Tianjin, Peoples R China.
C3 Tianjin University of Traditional Chinese Medicine; Tianjin University
   of Traditional Chinese Medicine
RP Jiang, MM (corresponding author), Tianjin Univ Tradit Chinese Med, State Key Lab Component Based Chinese Med, Tianjin, Peoples R China.; Jiang, MM (corresponding author), Tianjin Univ Tradit Chinese Med, Inst Tradit Chinese Med, Dept Pharm, Tianjin, Peoples R China.
EM miaomiaojiang@tjtcm.edu.cn
RI Yin, Jing/KDO-6274-2024; huang, sheng-jie/HTR-2562-2023
FU Tianjin Science and Technology Program [20ZYJDJC00120]; Natural Science
   Foundation of Tianjin City [18JCZDJC97700]; National Key Research and
   Development Program of China [2018YFC1707403]; National Natural Science
   Foundation of China [81573547]
FX This work was supported by the Tianjin Science and Technology Program
   (No. 20ZYJDJC00120), the Natural Science Foundation of Tianjin City (No.
   18JCZDJC97700), the National Key Research and Development Program of
   China (No. 2018YFC1707403) and the National Natural Science Foundation
   of China (No. 81573547).
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NR 78
TC 20
Z9 21
U1 7
U2 58
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD JUL 13
PY 2021
VL 12
AR 671708
DI 10.3389/fphar.2021.671708
PG 15
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA TR6GX
UT WOS:000679062000001
PM 34326769
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Tekola-Ayele, F
   Doumatey, AP
   Shriner, D
   Bentley, AR
   Chen, GJ
   Zhou, J
   Fasanmade, O
   Johnson, T
   Oli, J
   Okafor, G
   Eghan, BA 
   Agyenim-Boateng, K
   Adebamowo, C
   Amoah, A
   Acheampong, J
   Adeyemo, A
   Rotimi, CN
AF Tekola-Ayele, Fasil
   Doumatey, Ayo P.
   Shriner, Daniel
   Bentley, Amy R.
   Chen, Guanjie
   Zhou, Jie
   Fasanmade, Olufemi
   Johnson, Thomas
   Oli, Johnnie
   Okafor, Godfrey
   Eghan, Benjami A., Jr.
   Agyenim-Boateng, Kofi
   Adebamowo, Clement
   Amoah, Albert
   Acheampong, Joseph
   Adeyemo, Adebowale
   Rotimi, Charles N.
TI Genome-wide association study identifies African-ancestry specific
   variants for metabolic syndrome
SO MOLECULAR GENETICS AND METABOLISM
LA English
DT Article
DE Metabolic syndrome; Pleiotropy; Genome-wide association study; African
   ancestry
ID CARBONIC-ANHYDRASE INHIBITORS; ENDOPLASMIC-RETICULUM STRESS;
   ALPHA-T-CATENIN; INSULIN-RESISTANCE; ADIPOCYTE DIFFERENTIATION;
   TRANSCRIPTION FACTORS; SUSCEPTIBILITY GENES; QUANTITATIVE TRAITS; RISK
   SCORE; OBESITY
AB The metabolic syndrome (MetS) is a constellation of metabolic disorders that increase the risk of developing several diseases including type 2 diabetes and cardiovascular diseases. Although genome-wide association studies (GWAS) have successfully identified variants associated with individual traits comprising MetS, the genetic basis and pathophysiological mechanisms underlying the clustering of these traits remain unclear. We conducted GWAS of MetS in 1427 Africans from Ghana and Nigeria followed by replication testing and meta-analysis in another continental African sample from Kenya. Further replication testing was performed in an African American sample from the Atherosclerosis Risk in Communities (ARIC) study. We found two African-ancestry specific variants that were significantly associated with MetS: SNP rs73989312[A] near CA10 that conferred increased risk (P = 3.86 x 10(-8), OR = 6.80) and SNP rs77244975[C] in CTNNA3 that conferred protection against MetS (P = 1.63 x 10(-8), OR = 0.15). Given the exclusive expression of CA10 in the brain, our CA10 finding strengthens previously reported link between brain function and MetS. We also identified two variants that are not African specific: rs76822696[A] near RALYL associated with increased MetS risk (P = 7.37 x 10(-9), OR = 1.59) and rs7964157[T] near KSR2 associated with reduced MetS risk (P = 4.52 x 10(-8), P-meta = 7.82 x 10(-9), OR = 0.53). The KSR2 locus displayed pleiotropic associations with triglyceride and measures of blood pressure. Rare KSR2 mutations have been reported to be associated with early onset obesity and insulin resistance. Finally, we replicated the LPL and CETP loci previously found to be associated with MetS in Europeans. These findings provide novel insights into the genetics of MetS in Africans and demonstrate the utility of conducting trans-ethnic disease gene mapping studies for testing the cosmopolitan significance of GWAS signals of cardio-metabolic traits. Published by Elsevier Inc.
C1 [Tekola-Ayele, Fasil; Doumatey, Ayo P.; Shriner, Daniel; Bentley, Amy R.; Chen, Guanjie; Zhou, Jie; Adeyemo, Adebowale; Rotimi, Charles N.] NHGRI, Ctr Res Genom & Global Hlth, NIH, Bethesda, MD 20892 USA.
   [Fasanmade, Olufemi; Johnson, Thomas] Univ Lagos, Lagos, Nigeria.
   [Oli, Johnnie; Okafor, Godfrey] Univ Nigeria, Teaching Hosp, Enugu, Nigeria.
   [Eghan, Benjami A., Jr.; Agyenim-Boateng, Kofi; Acheampong, Joseph] Univ Sci & Technol, Dept Med, Kumasi, Ghana.
   [Adebamowo, Clement] Univ Maryland, Sch Med, Dept Epidemiol & Publ Hlth, Baltimore, MD 21201 USA.
   [Amoah, Albert] Univ Ghana, Sch Med, Dept Med, Accra, Ghana.
C3 National Institutes of Health (NIH) - USA; NIH National Human Genome
   Research Institute (NHGRI); University of Lagos; University of Nigeria;
   Kwame Nkrumah University Science & Technology; University System of
   Maryland; University of Maryland Baltimore; University of Ghana
RP Tekola-Ayele, F (corresponding author), NHGRI, Ctr Res Genom & Global Hlth, NIH, Bldg 12A,Room 4047,12 South Dr, Bethesda, MD 20892 USA.
EM ayeleft@mail.nih.gov; rotimic@mail.nih.gov
RI Fasanmade, Olufemi/IXX-0143-2023; Tekola-Ayele, Fasil/B-1771-2014;
   Adebamowo, Clement/C-8778-2011
OI Tekola-Ayele, Fasil/0000-0003-4194-9370; Adebamowo,
   Clement/0000-0002-6571-2880; Adeyemo, Adebowale/0000-0002-3105-3231;
   Shriner, Daniel/0000-0003-1928-5520; Fasanmade,
   Olufemi/0000-0001-7172-7053
FU Intramural Research Program of National Institutes of Health in Center
   for Research on Genomics and Global Health (CRGGH); National Human
   Genome Research Institute; National Institute of Diabetes and Digestive
   and Kidney Diseases; Center for Information Technology; Office of the
   Director at National Institutes of Health [1ZIAHG200362]; NIH from
   Office of Research on Minority Health [3T37TW00041-03S2]; National
   Center for Research Resources; National Heart, Lung, and Blood Institute
   [HHSN268201100005C, HHSN268201100006C, HHSN268201100007C,
   HHSN268201100008C, HHSN268201100009C, HHSN268201100010C,
   HHSN268201100011C, HHSN268201100012C]; Human Genome Research Institute
   grant [U01HG004402]
FX This work was supported in part by the Intramural Research Program of
   the National Institutes of Health in the Center for Research on Genomics
   and Global Health (CRGGH). The CRGGH is supported by the National Human
   Genome Research Institute, the National Institute of Diabetes and
   Digestive and Kidney Diseases, the Center for Information Technology,
   and the Office of the Director at the National Institutes of Health
   (1ZIAHG200362). Support for participant recruitment and initial genetic
   studies of the AADM study was provided by NIH grant No. 3T37TW00041-03S2
   from the Office of Research on Minority Health. The project was also
   supported in part by the National Center for Research Resources. The
   Atherosclerosis Risk in Communities (ARIC) Study is carried out as a
   collaborative study supported by National Heart, Lung, and Blood
   Institute contracts (HHSN268201100005C, HHSN268201100006C,
   HHSN268201100007C, HHSN268201100008C, HHSN268201100009C,
   HHSN268201100010C, HHSN268201100011C, and HHSN268201100012C). The
   authors thank the staff and participants of the ARIC study for their
   important contributions. Funding for ARIC Gene Environment Association
   Studies (GENEVA) was provided by National Human Genome Research
   Institute grant U01HG004402 (E. Boerwinkle).
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NR 87
TC 40
Z9 43
U1 0
U2 5
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 1096-7192
EI 1096-7206
J9 MOL GENET METAB
JI Mol. Genet. Metab.
PD DEC
PY 2015
VL 116
IS 4
BP 305
EP 313
DI 10.1016/j.ymgme.2015.10.008
PG 9
WC Endocrinology & Metabolism; Genetics & Heredity; Medicine, Research &
   Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Genetics & Heredity; Research & Experimental
   Medicine
GA CZ7KH
UT WOS:000367277800012
PM 26507551
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Rubio-Ruiz, ME
   Pérez-Torres, I
   Diaz-Diaz, E
   Pavón, N
   Guarner-Lans, V
AF Esther Rubio-Ruiz, Maria
   Perez-Torres, Israel
   Diaz-Diaz, Eulises
   Pavon, Natalia
   Guarner-Lans, Veronica
TI Non-steroidal anti-inflammatory drugs attenuate the vascular responses
   in aging metabolic syndrome rats
SO ACTA PHARMACOLOGICA SINICA
LA English
DT Article
DE NSAID; metabolic syndrome; aging; cytokine; cyclooxygenase; aortic ring;
   vascular reactivity; norepinephrine; acetylcholine
ID ENDOTHELIUM-DEPENDENT CONTRACTIONS; SMOOTH-MUSCLE-CELLS; LOW-DOSE
   ASPIRIN; NITRIC-OXIDE; PHOSPHOLIPASE A(2); BLOOD-PRESSURE; SARCOPENIC
   OBESITY; OXIDATIVE STRESS; SKELETAL-MUSCLE; CYCLOOXYGENASE-2
AB Aim: Metabolic syndrome (MS) and aging are low-grade systemic inflammatory conditions, and inflammation is a key component of endothelial dysfunction. The aim of this study was to investigate the effects of non-steroidal anti-inflammatory drugs (NSAIDs) upon the vascular reactivity in aging MS rats.
   Methods: MS was induced in young male rats by adding 30% sucrose in drinking water over 6, 12, and 18 months. When the treatment was finished, the blood samples were collected, and aortas were dissected out. The expression of COX isoenzymes and PLA(2) in the aortas was analyzed using Western blot analysis. The contractile responses of aortic rings to norepinephrine (1 mu mol/L) were measured in the presence or absence of different NSAIDs (10 mu mol/L for each).
   Results: Serum levels of pro-inflammatory cytokines (IL-6, TNF-alpha, and IL-1 beta) in control rats were remained stable during the aging process, whereas serum IL-6 in MS rats were significantly increased at 12 and 18 months. The levels of COX isoenzyme and PLA2 in aortas from control rats increased with the aging, whereas those in aortas from MS rats were irregularly increased with the highest levels at 6 months. Pretreatment with acetylsalicylic acid (a COX-1 preferential inhibitor), indomethacin (a non-selective COX inhibitor) or meloxicam (a COX-2 preferential inhibitor) decreased NE-induced contractions of aortic rings from MS rats at all the ages, with meloxicam being the most potent. Acetylsalicylic acid also significantly reduced the maximum responses of ACh-induced vasorelaxation of aortic rings from MS rats, but indomethacin and meloxicam had no effect.
   Conclusion: NSAIDs can directly affect vascular responses in aging MS rats. Understanding the effects of NSAIDs on blood vessels may improve the treatment of cardiovascular diseases and MS in the elders.
C1 [Esther Rubio-Ruiz, Maria; Guarner-Lans, Veronica] Inst Nacl Cardiol Ignacio Chavez, Dept Physiol, Mexico City, DF, Mexico.
   [Perez-Torres, Israel] Inst Nacl Cardiol Ignacio Chavez, Dept Pathol, Mexico City, DF, Mexico.
   [Pavon, Natalia] Inst Nacl Cardiol Ignacio Chavez, Dept Pharmacol, Mexico City, DF, Mexico.
   [Diaz-Diaz, Eulises] Inst Nacl Ciencias Med Nutr Salvador Zubiran, Dept Reprod Biol, Mexico City, DF, Mexico.
C3 National Institute of Cardiology - Mexico; National Institute of
   Cardiology - Mexico; National Institute of Cardiology - Mexico;
   Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran -
   Mexico
RP Guarner-Lans, V (corresponding author), Inst Nacl Cardiol Ignacio Chavez, Dept Physiol, Mexico City, DF, Mexico.
EM gualanv@yahoo.com
RI Pérez Torres, Israel/AAE-2579-2022; Guarner-Lans, Verónica/AFW-3723-2022
OI Perez-Torres, Israel/0000-0001-6510-2954; Guarner-Lans,
   Veronica/0000-0002-2655-7590; Pavon, Natalia/0000-0002-8520-5077;
   Rubio-Ruiz, Maria Esther/0000-0002-8844-2078
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NR 64
TC 13
Z9 14
U1 0
U2 7
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1671-4083
EI 1745-7254
J9 ACTA PHARMACOL SIN
JI Acta Pharmacol. Sin.
PD NOV
PY 2014
VL 35
IS 11
BP 1364
EP 1374
DI 10.1038/aps.2014.67
PG 11
WC Chemistry, Multidisciplinary; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Pharmacology & Pharmacy
GA AT5OC
UT WOS:000344991100002
PM 25263337
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Liu, S
   Zhang, HQ
   Yan, B
   Zhao, H
   Wang, YH
   Gao, TL
   Liang, H
AF Liu, Shuang
   Zhang, Huaqi
   Yan, Bei
   Zhao, Hui
   Wang, Yanhui
   Gao, Tianlin
   Liang, Hui
TI Maternal high-fructose consumption provokes placental oxidative stress
   resulting in asymmetrical fetal growth restriction in rats
SO JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION
LA English
DT Article
DE fructose; placenta; uric acid; oxidative stress; fetal growth
   restriction
ID METABOLIC SYNDROME; URIC-ACID; PREGNANCY; SUGAR; ANTIOXIDANTS;
   ASSOCIATION; RISK; DIET
AB We aimed to determine the impact of high-fructose intake during pregnancy on the fetal-placental unit in rats, which may be the initial mechanism of the programming effect of fructose. Pregnant Sprague-Dawley rats were randomly assigned to three groups and respectively provided tap water (n = 10), 10% (w/v) fructose solution (n = 10), and 10% (w/v) glucose solution (n = 10) from embryonic day 0 to 20. Compared with the control and glucose groups, significantly lower fetal length, fetal weight, placental weight, and fetus/placenta ratio were found in the fructose group on embryonic day 20 (all p<0.05). In parallel with markedly increased uric acid concentrations in the dams, significantly decreased antioxidant enzymes activities and mRNA expression levels were observed in placentas in the fructose group (all p<0.05). In the fructose group, placental mRNA and protein expression of nuclear factor erythroid 2-related factor 2 was markedly downregulated and kelch-like ECH-associated protein 1 was significantly upregulated (all p<0.05). In conclusion, high-fructose consumption during pregnancy drives augmented oxidative stress in rats. Placental insufficiency under oxidative stress contributes to asymmetrical fetal growth restriction.
C1 [Liu, Shuang; Zhang, Huaqi; Yan, Bei; Zhao, Hui; Wang, Yanhui; Gao, Tianlin; Liang, Hui] Qingdao Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, 308 Ningxia Rd, Qingdao 266071, Shandong, Peoples R China.
C3 Qingdao University
RP Liang, H (corresponding author), Qingdao Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, 308 Ningxia Rd, Qingdao 266071, Shandong, Peoples R China.
EM qdlianghui@126.com
RI Gao, Tianlin/K-7073-2017; wang, yanhui/HPG-3348-2023
FU National Natural Science Foundation of China [81803220, 81803225];
   Natural Science Foundation of Shandong Province [ZR2016HB18,
   ZR201807090374]
FX This work was supported by the National Natural Science Foundation of
   China (No. 81803220 and No. 81803225) and Natural Science Foundation of
   Shandong Province (No. ZR2016HB18 and No. ZR201807090374).
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NR 36
TC 9
Z9 10
U1 0
U2 10
PU JOURNAL CLINICAL BIOCHEMISTRY & NUTRITION
PI KYOTO
PA KYOTO PREFECTURAL UNIV MED, GRAD SCH MEDICAL SCIENCE, DEPT MOLECULAR
   GASTROENTEROLOGY & HEPATOLOGY, KYOTO, 602-8566, JAPAN
SN 0912-0009
EI 1880-5086
J9 J CLIN BIOCHEM NUTR
JI J. Clin. Biochem. Nutr.
PD JUL
PY 2021
VL 69
IS 1
BP 68
EP 76
DI 10.3164/jcbn.21-19
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA UE4WJ
UT WOS:000687890200009
PM 34376916
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Hagen, JM
   Sutterland, AL
   Edrisy, S
   Tan, HL
   de Haan, L
AF Hagen, Julia M.
   Sutterland, Arjen L.
   Edrisy, Sarah
   Tan, Hanno L.
   de Haan, Lieuwe
TI Accumulation rate of advanced glycation end products in recent onset
   psychosis: A longitudinal study
SO PSYCHIATRY RESEARCH
LA English
DT Article
DE Cardiovascular diseases; Metabolic syndrome; Oxidative stress; Psychotic
   disorders; Schizophrenia; Premature aging
ID CORONARY-HEART-DISEASE; OXIDATIVE STRESS; SKIN AUTOFLUORESCENCE;
   CARDIOVASCULAR-DISEASE; CARBOXYMETHYL-LYSINE; NATURAL COURSE; FOLLOW-UP;
   ALL-CAUSE; SCHIZOPHRENIA; INFLAMMATION
AB Schizophrenia is associated with excessive oxidative stress. Production of advanced glycation end products (AGEs) in the skin is strongly associated with oxidative stress. Increased skin AGE-levels have been demonstrated at cross-sectional level in recent onset psychosis and chronic schizophrenia, indicating increased cardiovascular risk. We aimed to investigate factors underlying AGE-accumulation and accumulation rate of AGEs in recent onset psychosis. From December 2016 through May 2017, 66 patients and 160 (highly educated) healthy controls from a previous case-control study of AGE-levels were assessed for a follow-up measurement 12-24 months after baseline. Possible determinants of AGE-accumulation were analyzed. AGE-accumulation rates in patients and controls were compared adjusted for relevant confounders. In healthy controls, a significant association of AGE-accumulation with ethnicity and tobacco exposure was found. An indication of a markedly higher AGE-accumulation rate was found in patients suffering from recent onset psychosis compared to healthy controls, independent of ethnicity and tobacco smoking, but not independent of cannabis use (more prevalent in patients than controls), although results were not significant.
C1 [Hagen, Julia M.; Sutterland, Arjen L.; Edrisy, Sarah; de Haan, Lieuwe] Univ Amsterdam, Dept Psychiat, Amsterdam UMC, Early Psychosis Sect, Meibergdreef 5, NL-1105 AZ Amsterdam, Netherlands.
   [Tan, Hanno L.] Univ Amsterdam, Dept Cardiol, Amsterdam UMC, Heart Ctr, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands.
   [Tan, Hanno L.] Netherlands Heart Inst, Moreelsepk 1, NL-3511 EP Utrecht, Netherlands.
C3 Vrije Universiteit Amsterdam; University of Amsterdam; University of
   Amsterdam
RP Hagen, JM (corresponding author), Univ Amsterdam, Dept Psychiat, Amsterdam UMC, Early Psychosis Sect, Meibergdreef 5, NL-1105 AZ Amsterdam, Netherlands.
EM j.m.hagen@amsterdamumc.nl; a.l.sutterland@amsterdamumc.nl;
   h.l.tan@amsterdamumc.nl; l.dehaan@amsterdamumc.nl
RI Sutterland, Arjen/AAD-2050-2020
OI Hagen, Julia/0000-0002-5085-1108
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NR 65
TC 7
Z9 7
U1 0
U2 4
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0165-1781
EI 1872-7123
J9 PSYCHIAT RES
JI Psychiatry Res.
PD SEP
PY 2020
VL 291
AR 113192
DI 10.1016/j.psychres.2020.113192
PG 8
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA NK6VL
UT WOS:000566872600045
PM 32574898
OA hybrid
DA 2025-06-11
ER

PT J
AU Chakrabarti, S
   Liao, W
   Davidge, ST
   Wu, JP
AF Chakrabarti, Subhadeep
   Liao, Wang
   Davidge, Sandra T.
   Wu, Jianping
TI Milk-derived tripeptides IPP (Ile-Pro-Pro) and VPP (Val-Pro-Pro)
   differentially modulate angiotensin II effects on vascular smooth muscle
   cells
SO JOURNAL OF FUNCTIONAL FOODS
LA English
DT Article
DE IPP; VPP; Lactotripeptides; VSMC; Inflammation; Oxidative stress
ID SPONTANEOUSLY HYPERTENSIVE-RATS; IN-VITRO MODEL; NF-KAPPA-B; BIOACTIVE
   PEPTIDES; BLOOD-PRESSURE; METABOLIC SYNDROME; OXIDATIVE STRESS; AT(1)
   RECEPTOR; GASTROINTESTINAL DIGESTION; ARTERIAL-HYPERTENSION
AB Hyperactivity of the Renin-Angiotensin System (RAS) is a hallmark of hypertension. Angiotensin II (AngII), the active component of RAS, not only promotes vasoconstriction but also contributes to proliferation, inflammation and oxidative stress in vascular smooth muscle cells (VSMC) that predispose to atherosclerosis. Milk derived bioactive peptides IPP (Ile-Pro-Pro) and VPP (Val-Pro-Pro) exert anti hypertensive effects through RAS modulation. Here we evaluated the ability of these peptides to attenuate the effects of AngII on cultured VSMC. We found that VPP significantly inhibited AngII induced cell proliferation, inflammation and oxidative stress while IPP only showed anti-oxidant actions. Both peptides abolished AngII mediated activation of pro-inflammatory nuclear factor kappa B (NF-kappa B) pathway but only VPP could attenuate activation of extracellular signal regulated kinases (ERK) 1/2. These results demonstrate differential modulation of AngII actions on VSMC by anti-hypertensive milk peptides and indicate the potential for VPP in mitigating the vascular complications of hypertension. (C) 2016 Elsevier Ltd. All rights reserved.
C1 [Chakrabarti, Subhadeep; Liao, Wang; Wu, Jianping] Univ Alberta, Dept Agr Food & Nutr Sci, Edmonton, AB T6G 2P5, Canada.
   [Davidge, Sandra T.] Univ Alberta, Dept Obstet & Gynecol, Edmonton, AB T6G 2P5, Canada.
   [Davidge, Sandra T.] Univ Alberta, Dept Physiol, Edmonton, AB T6G 2P5, Canada.
   [Chakrabarti, Subhadeep; Davidge, Sandra T.; Wu, Jianping] Univ Alberta, Cardiovasc Res Ctr, Edmonton, AB T6G 2P5, Canada.
   [Chakrabarti, Subhadeep; Davidge, Sandra T.] Univ Alberta, Women & Childrens Hlth Res Inst, Edmonton, AB T6G 2P5, Canada.
C3 University of Alberta; University of Alberta; University of Alberta;
   University of Alberta; University of Alberta
RP Wu, JP (corresponding author), Univ Alberta, Dept Agr Food & Nutr Sci, Ag For Ctr 4 10, Edmonton, AB T6G 2P5, Canada.
EM jwu3@ualberta.ca
RI Wu, Jianping/H-9150-2012; Chakrabarti, Subhadeep/AAD-1078-2022
OI Davidge, Sandra/0000-0002-5559-4905; Liao, Wang/0000-0001-8319-2199
FU Alberta Livestock and Meat Agency (ALMA); Natural Sciences and
   Engineering Research Council (NSERC); Women and Children's Health
   Research Institute through Stollery Children's Hospital Foundation;
   Canadian Institutes for Health Research (CIHR)
FX This work was supported by grants from Alberta Livestock and Meat Agency
   (ALMA) and the Natural Sciences and Engineering Research Council (NSERC)
   to JW. SD is supported by the Women and Children's Health Research
   Institute through the generosity of the Stollery Children's Hospital
   Foundation and supporters of the Lois Hole Hospital for Women along with
   grants from the Canadian Institutes for Health Research (CIHR). SD is a
   Canada Research Chair in Maternal and Fetal Cardiovascular Health.
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NR 57
TC 34
Z9 36
U1 6
U2 35
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1756-4646
J9 J FUNCT FOODS
JI J. Funct. Food.
PD MAR
PY 2017
VL 30
BP 151
EP 158
DI 10.1016/j.jff.2016.12.022
PG 8
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA EL9FF
UT WOS:000394924700018
DA 2025-06-11
ER

PT J
AU Alcocer-Gómez, E
   Garrido-Maraver, J
   Bullón, P
   Marín-Aguilar, F
   Cotán, D
   Carrión, AM
   Alvarez-Suarez, JM
   Giampieri, F
   Sánchez-Alcazar, JA
   Battino, M
   Cordero, MD
AF Alcocer-Gomez, Elisabet
   Garrido-Maraver, Juan
   Bullon, Pedro
   Marin-Aguilar, Fabiola
   Cotan, David
   Carrion, Angel M.
   Miguel Alvarez-Suarez, Jose
   Giampieri, Francesca
   Antonio Sanchez-Alcazar, Jose
   Battino, Maurizio
   Cordero, Mario D.
TI Metformin and caloric restriction induce an AMPK-dependent restoration
   of mitochondrial dysfunction in fibroblasts from Fibromyalgia patients
SO BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
LA English
DT Article
DE Fibromyalgia; AMPK; Mitochondria; Oxidative stress; Metformin; Caloric
   restriction
ID OXIDATIVE STRESS; ANTIOXIDANT STATUS; HUMAN-CELLS; SEVERITY; WOMEN;
   INDEX
AB Impaired AMPK is associated with a wide spectrum of clinical and pathological conditions, ranging from obesity, altered responses to exercise or metabolic syndrome, to inflammation, disturbed mitochondrial biogenesis and defective response to energy stress. Fibromyalgia (FM) is a world-wide diffused musculoskeletal chronic pain condition that affects up to 5% of the general population and comprises all the above mentioned pathophysiological states. Here, we tested the involvement of AMPK activation in fibroblasts derived from FM patients. AMPK was not phosphorylated in fibroblasts from FM patients and was associated with decreased mitochondrial biogenesis, reduced oxygen consumption, decreased antioxidant enzymes expression levels and mitochondrial dysfunction. However, mtDNA sequencing analysis did not show any important alterations which could justify the mitochondrial defects. AMPK activation in FM fibroblast was impaired in response to moderate oxidative stress. In contrast, AMPK activation by metformin or incubation with serum from caloric restricted mice improved the response to moderate oxidative stress and mitochondrial metabolism in FM fibroblasts. These results suggest that AMPK plays an essential role in FM pathophysiology and could represent the basis for a valuable new therapeutic target/strategy. Furthermore, both metformin and caloric restriction could be an interesting therapeutic approach in FM. (C) 2015 Elsevier B.V. All rights reserved.
C1 [Alcocer-Gomez, Elisabet; Bullon, Pedro; Marin-Aguilar, Fabiola; Cordero, Mario D.] Univ Seville, Res Lab, Dept Oral Med, E-41009 Seville, Spain.
   [Alcocer-Gomez, Elisabet; Garrido-Maraver, Juan; Cotan, David; Antonio Sanchez-Alcazar, Jose] Univ Pablo Olavide, CSIC Junta Andalucia, CABD, Seville 41013, Spain.
   [Alcocer-Gomez, Elisabet; Garrido-Maraver, Juan; Cotan, David; Antonio Sanchez-Alcazar, Jose] ISCIII, Ctr Invest Biomed Red Enfermedades Raras CIBERER, Seville 41013, Spain.
   [Bullon, Pedro] Univ Seville, Sch Dent, Dept Periodontol, Seville, Spain.
   [Carrion, Angel M.] Univ Pablo Olavide Sevilla, Div Neurociencias, Seville 41013, Spain.
   [Miguel Alvarez-Suarez, Jose; Battino, Maurizio] Univ Politecn Marche, Fac Med, Dipartimento Sci Clin Specialist & Odontostomatol, Sez Biochim, I-60131 Ancona, Italy.
   [Miguel Alvarez-Suarez, Jose] Univ Int Iberoamer UNINI, Area Nutr & Salud, Campeche 24040, Mexico.
   [Miguel Alvarez-Suarez, Jose] Univ Nacl Chimborazo, Fac Ciencias Salud, Riobamba, Ecuador.
   [Giampieri, Francesca] Univ Politecn Marche, Dipartimento Sci Agr Alimentari & Ambientali D3A, I-60131 Ancona, Italy.
   [Battino, Maurizio] UEA, Ctr Nutr & Hlth, Santander 39011, Spain.
C3 University of Sevilla; Consejo Superior de Investigaciones Cientificas
   (CSIC); Universidad Pablo de Olavide; CSIC - Andalusian Center for
   Developmental Biology (CABD); CIBER - Centro de Investigacion Biomedica
   en Red; CIBERER; Instituto de Salud Carlos III; University of Sevilla;
   Universidad Pablo de Olavide; Marche Polytechnic University; Marche
   Polytechnic University
RP Cordero, MD (corresponding author), Univ Seville, Res Lab, Dept Oral Med, C Avicena S-N, E-41009 Seville, Spain.
EM mdcormor@us.es
RI Giampieri, Francesca/I-1911-2015; GARRIDO-MARAVER, JUAN/S-3846-2016;
   Carrion Rodriguez, Angel Manuel/K-5875-2014; Alvarez-Suarez, Jose
   M./M-7160-2014; Bullon, Pedro/E-6319-2010; Sanchez-Alcazar, Jose
   A./L-4925-2014; Cordero, Mario D./L-8006-2014; Battino,
   Maurizio/E-6103-2012
OI Giampieri, Francesca/0000-0002-8151-9132; GARRIDO-MARAVER,
   JUAN/0000-0003-4534-4109; Carrion Rodriguez, Angel
   Manuel/0000-0001-8158-9512; Alvarez-Suarez, Jose M./0000-0001-8509-1498;
   Bullon, Pedro/0000-0003-4873-4196; Alcocer-Gomez,
   Elisabet/0000-0001-9799-431X; Sanchez-Alcazar, Jose
   A./0000-0001-9705-1469; Cordero, Mario D./0000-0003-0151-3644; Battino,
   Maurizio/0000-0002-7250-1782
FU Federacion Andaluza de Fibromialgia y Fatiga Cronica (ALBA Andalucia);
   Grupo de Investigacion Junta de Andalucia [CTS113]
FX This work has been supported by Federacion Andaluza de Fibromialgia y
   Fatiga Cronica (ALBA Andalucia) and Grupo de Investigacion Junta de
   Andalucia CTS113. Authors are, indebted with Ms Monica Glebocki for
   extensive editing of the manuscript
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NR 27
TC 39
Z9 43
U1 1
U2 24
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0925-4439
EI 1879-260X
J9 BBA-MOL BASIS DIS
JI Biochim. Biophys. Acta-Mol. Basis Dis.
PD JUL
PY 2015
VL 1852
IS 7
BP 1257
EP 1267
DI 10.1016/j.bbadis.2015.03.005
PG 11
WC Biochemistry & Molecular Biology; Biophysics; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Cell Biology
GA CJ7YB
UT WOS:000355715200005
PM 25779083
OA Bronze
DA 2025-06-11
ER

PT J
AU Khadir, A
   Tiss, A
   Kavalakatt, S
   Behbehani, K
   Dehbi, M
   Elkum, N
AF Khadir, Abdelkrim
   Tiss, Ali
   Kavalakatt, Sina
   Behbehani, Kazem
   Dehbi, Mohammed
   Elkum, Naser
TI Gender-Specific Association of Oxidative Stress and Inflammation with
   Cardiovascular Risk Factors in Arab Population
SO MEDIATORS OF INFLAMMATION
LA English
DT Article
ID CORONARY-HEART-DISEASE; BODY-MASS INDEX; METABOLIC SYNDROME;
   SEX-DIFFERENCES; WAIST CIRCUMFERENCE; OBESITY; MARKERS; WOMEN; MEN;
   PREVALENCE
AB Background. The impact of gender difference on the association betweenmetabolic stress and cardiovascular disease (CVD) remains unclear. We have investigated, for the first time, the gender effect on the oxidative and inflammatory stress responses and assessed their correlation with classical cardiometabolites in Arab population. Methods. A total of 378 adult Arab participants (193 females) were enrolled in this cross-sectional study. Plasma levels of CRP, IL-6, IL-8, TNF-alpha, ROS, TBARs, and PON1 were measured and correlated with anthropometric and cardiometabolite parameters of the study population. Results. Compared to females, males had significantly higher FBG, HbA1c, TG, and blood pressure but lower BMI, TC, and HDL (P < 0.05). After adjustment for BMI and WC, females had higher levels of ROS, TBARS, and CRP (P < 0.001) where as males had increased levels of IL-8, IL-6, and TNF-alpha (P < 0.05). Moreover, after adjustment for age, BMI, and gender, the levels of TNF-alpha, IL-6, and ROS were associated with central obesity but not general obesity. Conclusion. Inflammation and oxidative stress contribution to CVD risk in Arab population linked to gender and this risk is better reflected by central obesity. Arab females might be at risk of CVD complications due to increased oxidative stress.
C1 [Khadir, Abdelkrim; Tiss, Ali; Kavalakatt, Sina; Behbehani, Kazem] Dasman Diabet Inst, Dept Biomed Res, Kuwait 15462, Kuwait.
   [Dehbi, Mohammed] Qatar Biomed Res Inst, Diabet Res Ctr, Doha, Qatar.
   [Elkum, Naser] Sidra Med & Res Ctr, Clin Epidemiol Div, Doha, Qatar.
C3 Dasman Diabetes Institute (DDI); Qatar Foundation (QF); Hamad Bin
   Khalifa University-Qatar; Qatar Biomedical Research Institute (QBRI);
   Sidra Medical & Research Center
RP Elkum, N (corresponding author), Sidra Med & Res Ctr, Clin Epidemiol Div, Doha, Qatar.
EM nelkum@hotmail.com
RI Elkum, Naser/AAU-5555-2020; Tiss, Ali/L-6656-2019
OI Tiss, Ali/0000-0002-3024-5370; Elkum, Naser/0000-0002-0457-0444;
   kavalakatt, sina/0000-0003-3795-1881
FU Kuwait Foundation for the Advancement of Sciences (KFAS) [RA-2010-004]
FX The authors would like to thank Biostatistics & Epidemiology Department
   study team for their efforts and excellent work in conducting the study.
   They are grateful to the Biochemistry and Molecular Biology Unit
   members, Clinical Laboratory, and the Tissue Bank Core Facility at DDI
   for their contribution to performing the biochemical profile analysis
   and handling samples, respectively. Finally, they are grateful to the
   senior management, Scientific Advisory Board, and Ethical Review
   Committee of DDI for their unwavering support and valuable
   recommendations. This research project (RA-2010-004) was funded by
   Kuwait Foundation for the Advancement of Sciences (KFAS).
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NR 50
TC 8
Z9 10
U1 0
U2 0
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 0962-9351
EI 1466-1861
J9 MEDIAT INFLAMM
JI Mediat. Inflamm.
PY 2015
VL 2015
AR 512603
DI 10.1155/2015/512603
PG 11
WC Cell Biology; Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Immunology
GA CF9HL
UT WOS:000352875100001
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Chu, P
   Gotink, RA
   Yeh, GY
   Goldie, SJ
   Hunink, MGM
AF Chu, Paula
   Gotink, Rinske A.
   Yeh, Gloria Y.
   Goldie, Sue J.
   Hunink, M. G. Myriam
TI The effectiveness of yoga in modifying risk factors for cardiovascular
   disease and metabolic syndrome: A systematic review and meta-analysis of
   randomized controlled trials
SO EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
LA English
DT Review
DE Yoga; cardiovascular disease; metabolic syndrome; systematic review;
   meta-analysis
ID TYPE-2 DIABETES-MELLITUS; LIPID PROFILE; OLDER-ADULTS; HATHA-YOGA;
   SMOKING-CESSATION; OXIDATIVE STRESS; PHYSICAL-FITNESS; EXERCISE;
   INTERVENTION; PROGRAM
AB Background Yoga, a popular mind-body practice, may produce changes in cardiovascular disease (CVD) and metabolic syndrome risk factors.
   Design This was a systematic review and random-effects meta-analysis of randomized controlled trials (RCTs).
   Methods Electronic searches of MEDLINE, EMBASE, CINAHL, PsycINFO, and The Cochrane Central Register of Controlled Trials were performed for systematic reviews and RCTs through December 2013. Studies were included if they were English, peer-reviewed, focused on asana-based yoga in adults, and reported relevant outcomes. Two reviewers independently selected articles and assessed quality using Cochrane's Risk of Bias tool.
   Results Out of 1404 records, 37 RCTs were included in the systematic review and 32 in the meta-analysis. Compared to non-exercise controls, yoga showed significant improvement for body mass index (-0.77kg/m(2) (95% confidence interval -1.09 to -0.44)), systolic blood pressure (-5.21mmHg (-8.01 to -2.42)), low-density lipoprotein cholesterol (-12.14mg/dl (-21.80 to -2.48)), and high-density lipoprotein cholesterol (3.20mg/dl (1.86 to 4.54)). Significant changes were seen in body weight (-2.32kg (-4.33 to -0.37)), diastolic blood pressure (-4.98mmHg (-7.17 to -2.80)), total cholesterol (-18.48mg/dl (-29.16 to -7.80)), triglycerides (-25.89mg/dl (-36.19 to -15.60), and heart rate (-5.27 beats/min (-9.55 to -1.00)), but not fasting blood glucose (-5.91mg/dl (-16.32 to 4.50)) nor glycosylated hemoglobin (-0.06% Hb (-0.24 to 0.11)). No significant difference was found between yoga and exercise. One study found an impact on smoking abstinence.
   Conclusions There is promising evidence of yoga on improving cardio-metabolic health. Findings are limited by small trial sample sizes, heterogeneity, and moderate quality of RCTs.
C1 [Chu, Paula] Harvard Univ, Dept Hlth Policy, Cambridge, MA 02138 USA.
   [Chu, Paula; Goldie, Sue J.; Hunink, M. G. Myriam] Harvard Univ, Sch Publ Hlth, Ctr Hlth Decis Sci, Cambridge, MA 02138 USA.
   [Gotink, Rinske A.; Hunink, M. G. Myriam] Erasmus MC, Dept Epidemiol, Room Na 2818,POB 2040, NL-3000 CA Rotterdam, Netherlands.
   [Gotink, Rinske A.; Hunink, M. G. Myriam] Erasmus MC, Dept Radiol, Room Na 2818,POB 2040, NL-3000 CA Rotterdam, Netherlands.
   [Yeh, Gloria Y.] Harvard Univ, Div Gen Med & Primary Care, Sch Med, Cambridge, MA 02138 USA.
   [Goldie, Sue J.; Hunink, M. G. Myriam] Harvard Univ, Sch Publ Hlth, Dept Hlth Policy & Management, Cambridge, MA 02138 USA.
C3 Harvard University; Harvard University; Harvard T.H. Chan School of
   Public Health; Erasmus University Rotterdam; Erasmus MC; Erasmus
   University Rotterdam; Erasmus MC; Harvard University; Harvard
   University; Harvard T.H. Chan School of Public Health
RP Hunink, MGM (corresponding author), Erasmus MC, Dept Epidemiol, Room Na 2818,POB 2040, NL-3000 CA Rotterdam, Netherlands.; Hunink, MGM (corresponding author), Erasmus MC, Dept Radiol, Room Na 2818,POB 2040, NL-3000 CA Rotterdam, Netherlands.
EM m.hunink@erasmusmc.nl
OI Hunink, Myriam/0000-0002-2942-2798; Gotink, Rinske/0000-0002-4760-3226
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NR 78
TC 128
Z9 155
U1 1
U2 61
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 2047-4873
EI 2047-4881
J9 EUR J PREV CARDIOL
JI Eur. J. Prev. Cardiol.
PD FEB
PY 2016
VL 23
IS 3
BP 291
EP 307
DI 10.1177/2047487314562741
PG 17
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA DC9FP
UT WOS:000369526800008
PM 25510863
OA Bronze
DA 2025-06-11
ER

PT J
AU Huang, XQ
   Sun, MX
   Li, DX
   Liu, J
   Guo, HB
   Dong, YA
   Jiang, L
   Pan, Q
   Man, Y
   Wang, S
   Li, JA
AF Huang, Xiuqing
   Sun, Mingxiao
   Li, Dongxiao
   Liu, Jin
   Guo, Hanbang
   Dong, Yuan
   Jiang, Lei
   Pan, Qi
   Man, Yong
   Wang, Shu
   Li, Jian
TI Augmented NADPH oxidase activity and p22phox expression in monocytes
   underlie oxidative stress of patients with type 2 diabetes mellitus
SO DIABETES RESEARCH AND CLINICAL PRACTICE
LA English
DT Article
DE Diabetes mellitus; Monocytes; Oxidative stress; NADPH oxidase
ID HIGH GLUCOSE; SUPEROXIDE GENERATION; METABOLIC SYNDROME;
   ENDOTHELIAL-CELLS; NAD(P)H OXIDASE; ATHEROSCLEROSIS; INCREASES
AB Background: This study was to test the hypothesis that enhanced oxidative stress is induced in monocytes with over-activated NADPH oxidase during the development of type 2 diabetes mellitus.
   Methods: Levels of glucose and lipids were analyzed in 73 diabetic patients and 36 controls. Superoxide dismutase (SOD), malondialdehyde (MDA), reactive oxygen species (ROS) and protein carbonylation were tested. Expression of NADPH oxidase was examined and p47phox translocation was assessed.
   Results: With the abnormality of glucose and lipid metabolism, diabetic patients showed a higher oxidative stress state indicated by decreased SOD activity but elevated MDA and protein carbonylation level. Monocytes in diabetes also showed elevated ROS generation and protein carbonylation level. Furthermore, NADPH oxidase was highly activated in monocytes represented by p22phox up-regulation and p47phox translocation. Significant positive bivariate correlation was found between glucose and MDA level as well as p22phox expression. In vitro experiments also indicated that glucose could stimulate ROS generation in a NADPH oxidase dependent manner. Moreover, we carried out same measurement in 40 diabetic patients with anti-diabetic intervention and obtained the reinforced results.
   Conclusions: Hyperglycemia is the main factor which induces oxidative stress mainly by activation of NADPH oxidase in monocytes of diabetic patients. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
C1 [Huang, Xiuqing; Guo, Hanbang; Dong, Yuan; Man, Yong; Wang, Shu; Li, Jian] Beijing Hosp, Key Lab Geriatr, Beijing 100730, Peoples R China.
   [Huang, Xiuqing; Guo, Hanbang; Dong, Yuan; Man, Yong; Wang, Shu; Li, Jian] Beijing Inst Geriatr, Minist Hlth, Beijing 100730, Peoples R China.
   [Sun, Mingxiao; Li, Dongxiao; Jiang, Lei; Pan, Qi] Beijing Hosp, Dept Endocrinol & Metab, Beijing 100730, Peoples R China.
   [Liu, Jin] Beijing Normal Univ, Coll Life Sci, Beijing 100875, Peoples R China.
C3 Beijing Hospital; Beijing Hospital; Beijing Normal University
RP Li, JA (corresponding author), Beijing Hosp, Key Lab Geriatr, Beijing 100730, Peoples R China.
EM lijliy@hotmail.com
RI Ji, Jian/KIB-0951-2024
FU National Basic Research Program of China [2006CB 503910]; National
   Natural Science Foundation of China [30572082, 30801218]; Natural
   Science Foundation of Beijing [7052059]
FX This project was funded by National Basic Research Program of China
   (2006CB 503910), National Natural Science Foundation of China (30572082,
   30801218) and Natural Science Foundation of Beijing (7052059).
CR Avogaro A, 2003, J CLIN ENDOCR METAB, V88, P1753, DOI 10.1210/jc.2002-021025
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NR 16
TC 40
Z9 43
U1 1
U2 15
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0168-8227
EI 1872-8227
J9 DIABETES RES CLIN PR
JI Diabetes Res. Clin. Pract.
PD MAR
PY 2011
VL 91
IS 3
BP 371
EP 380
DI 10.1016/j.diabres.2010.12.026
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 732EW
UT WOS:000288168800021
PM 21237524
DA 2025-06-11
ER

PT J
AU Song, J
   Zhang, HX
   Sun, YN
   Guo, RM
   Zhong, DX
   Xu, RX
   Song, M
AF Song, Juan
   Zhang, Hongxia
   Sun, Yanni
   Guo, Ruimin
   Zhong, Dongxiang
   Xu, Runxi
   Song, Meng
TI Omentin-1 protects renal function of mice with type 2 diabetic
   nephropathy via regulating miR-27a-Nrf2/Keap1 axis
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Article
DE Omentin-1; Diabetic nephropathy; miR-27a; Nuclear factor erythroid
   2-like 2; Oxidative stress
ID ACTIVATION; EXPRESSION; MECHANISM; PROFILES; PROMOTES; PLASMA
AB Omentin-1, a novel identified adipokine, always significantly decreases in patients with metabolic syndrome. However, the functional roles of omentin-1 in diabetic nephropathy (DN) remains largely unknown. In the present study, we found that omentin-1 treatment could improve renal function of type 2 diabetic db/db mice. ELISA assay and immunohistochemistry staining showed that omentin-1 reduced the productions of proin-flammatory cytokines (IFN-gamma, TNF-alpha, MCP-1 and IL-8), and improved oxidative stress level (CAT, MDA and SOD) in the kidney tissue, indicating omentin-1 could relieved the inflammatory response and suppressed oxidative stress. Mechanistic analysis demonstrated that omentin-1 down-regulated miR-27a expression, and subsequently inhibited oxidative stress and inflammation. Luciferase reporter assay and western blot further revealed that miR-27a directly targeted the 3' untranslated region (UTR) of nuclear factor erythroid 2-like 2 (Nrf2) and reduced its expression in type 2 DN. Taken together, these findings provide a new function of omentin-1 in renal protection and also delineate multiple potential targets for therapeutic intervention for type 2 DN.
C1 [Song, Juan; Sun, Yanni; Guo, Ruimin; Zhong, Dongxiang; Xu, Runxi; Song, Meng] Shanghai Univ Tradit Chinese Med, Putuo Hosp, Dept Emergency, Shanghai 200062, Peoples R China.
   [Zhang, Hongxia] Shanxi Prov Peoples Hosp, Dept Endocrinol, Taiyuan 030012, Shanxi, Peoples R China.
C3 Shanghai University of Traditional Chinese Medicine; Shanxi People's
   Hospital
RP Sun, YN (corresponding author), Shanghai Univ Tradit Chinese Med, Putuo Hosp, Dept Emergency, Shanghai 200062, Peoples R China.
EM ssyynn898@163.com
RI SUN, Yanni/AHC-4163-2022; Zhang, Hongxia/AAB-8995-2022
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NR 33
TC 46
Z9 50
U1 0
U2 27
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD NOV
PY 2018
VL 107
BP 440
EP 446
DI 10.1016/j.biopha.2018.08.002
PG 7
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA GU1PC
UT WOS:000445036200048
PM 30103116
DA 2025-06-11
ER

PT J
AU Kim, YK
   Yang, YM
AF Kim, Young Kyun
   Yang, Young-Mo
TI An analysis of the associations of high-sensitivity C-reactive protein
   and uric acid with metabolic syndrome components in Korean adults by
   sex: a cross-sectional study using the Korea national health and
   nutrition examination survey 2016-2018
SO BMC ENDOCRINE DISORDERS
LA English
DT Article
DE High-sensitivity C-reactive protein; Uric acid; Metabolic syndrome; Sex;
   Koreans; Cross-sectional study
ID NORMAL-WEIGHT; RISK-FACTORS; WAIST CIRCUMFERENCE; DIABETES-MELLITUS;
   OXIDATIVE STRESS; BODY-COMPOSITION; SERUM; OBESITY; PREVALENCE;
   HYPERTENSION
AB BackgroundLow-grade inflammation plays a role in the pathogenesis of metabolic syndrome (MetS), and measuring levels of inflammatory molecules, such as high-sensitivity C-reactive protein (hs-CRP), may indicate Mets progression. Serum uric acid (SUA) has also been identified as an independent risk factor for MetS. This study aimed to investigate the association between MetS components and levels of serum hs-CRP and SUA using representative and reliable data for the Korean population.MethodsThis study used the data of the Korea National Health and Nutrition Examination Survey 2016-2018, a cross-sectional and nationally representative survey performed by the Korean Centers for Disease Control and Prevention.ResultsWe analysed the data of 13,454 individuals. High hs-CRP levels were observed in 1,164 (8.7%) subjects while 3,296 (24.5%) subjects had high SUA levels. Moreover, hs-CRP was negatively correlated with serum high-density lipoprotein (HDL) (OR, 1.703; 95% CI, 1.431-2.027). When stratified by sex, this trend remained, but the correlation was stronger in women than in men. Furthermore, high SUA levels were significantly associated with hypertension (HTN) (OR, 1.399; 95% CI, 1.210-1.616), hypertriglyceridemia (OR, 1.735; 95% CI, 1.486-2.026), and low HDL (OR, 1.257; 95% CI, 1.106-1.429), but not with diabetes mellitus (DM) (OR, 0.478; 95% CI, 0.382-0.597). When grouped by sex, this trend remained, however, all MetS components were found to be more prevalent in women with high SUA.ConclusionsOur findings showed that low HDL was more prevalent in subjects with high hs-CRP, and high SUA levels were observed in subjects with HTN, hypertriglyceridemia, and low HDL. However, the prevalence of high SUA was lower in diabetic subjects.
C1 [Kim, Young Kyun; Yang, Young-Mo] Chosun Univ, Coll Pharm, Dept Pharm, 309 Pilmun Daero, Gwangju 61452, South Korea.
C3 Chosun University
RP Yang, YM (corresponding author), Chosun Univ, Coll Pharm, Dept Pharm, 309 Pilmun Daero, Gwangju 61452, South Korea.
EM yyang@chosun.ac.kr
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NR 71
TC 3
Z9 3
U1 0
U2 0
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1472-6823
J9 BMC ENDOCR DISORD
JI BMC Endocr. Disord.
PD AUG 3
PY 2023
VL 23
IS 1
AR 163
DI 10.1186/s12902-023-01417-z
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA N9PG4
UT WOS:001040241000002
PM 37537612
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Sladowska-Kozlowska, J
   Litwin, M
   Niemirska, A
   Wierzbicka, A
   Roszczynko, M
   Szperl, M
AF Sladowska-Kozlowska, Joanna
   Litwin, Mieczysaw
   Niemirska, Anna
   Wierzbicka, Aldona
   Roszczynko, Marta
   Szperl, Magorzata
TI Associations of the eNOS G894T gene polymorphism with target
   organ damage in children with newly diagnosed primary hypertension
SO PEDIATRIC NEPHROLOGY
LA English
DT Article
DE Primary hypertension; Children; Intima media thickness; eNOS G894T gene
   polymorphism; Target organ damage; Nitric oxide
ID NITRIC-OXIDE SYNTHASE; INTIMA-MEDIA THICKNESS; LEFT-VENTRICULAR MASS;
   AMBULATORY BLOOD-PRESSURE; GLU298ASP POLYMORPHISM; COMMON VARIANT;
   METABOLIC SYNDROME; REFERENCE VALUES; RISK-FACTOR; ADOLESCENTS
AB The endothelial nitric oxide synthase (eNOS) G894T gene polymorphism is associated with the risk of primary hypertension (PH) and vascular complications in adults with PH.
   We explored the associations of the G894T polymorphism with 24-h ambulatory blood pressure, left ventricular mass (LVM), carotid intima media thickness (cIMT), urinary albumin excretion, oxidative stress and inflammatory parameters in 126 children with newly diagnosed PH and in 83 healthy children.
   Among the 126 children with PH 92 (73 %) had ambulatory hypertension and 34 (27 %) had severe ambulatory hypertension. Left ventricular hypertrophy (LVH) was detected in 39 (31 %) patients, cIMT of > 2 standard deviation scores in 21 (16.6 %) patients, albuminuria of > 30 mg/24 h in 18 (14.3 %) patients and metabolic syndrome (MS) in 22 (17.5 %) patients. The frequency of the T allele was 52.4 % in the PH group and 54.2 % in the control group (not significant), and in both groups the frequency of the T allele was consistent with the Hardy-Weinberg equilibrium. Compared with G allele carriers, hypertensive T allele carriers had increased cIMT (p < 0.05) and more severe albuminuria (not significant, p = 0.1); there was no difference between the groups in hypertension severity and LVM. T and G allele distribution did not differ between patients with and without metabolic syndrome. No significant correlations between the assessed parameters and the eNOS G894T gene polymorphism were found in the controls, although T allele carriers tended to have an increased cIMT (p = 0.09).
   The eNOS T allele is not more prevalent among hypertensive children than among healthy ones, but it is associated with early vascular damage in children with PH, independent of metabolic abnormalities. No associations between the eNOS G894T polymorphism and metabolic abnormalities were found.
C1 [Sladowska-Kozlowska, Joanna; Litwin, Mieczysaw; Niemirska, Anna] Childrens Mem Hlth Inst, Dept Nephrol & Arterial Hypertens, Warsaw, Poland.
   [Wierzbicka, Aldona] Childrens Mem Hlth Inst, Dept Biochem & Expt Med, Warsaw, Poland.
   [Roszczynko, Marta; Szperl, Magorzata] Inst Cardiol, Dept Mol Biol, Warsaw, Poland.
C3 Children's Memorial Health Institute; Children's Memorial Health
   Institute; Institute of Cardiology - Poland
RP Litwin, M (corresponding author), Childrens Mem Hlth Inst, Dept Nephrol & Arterial Hypertens, Warsaw, Poland.
EM m.litwin@ipczd.pl
RI ; Litwin, Mieczyslaw/L-4648-2017; Niemirska, Anna/W-2780-2018
OI Wierzbicka-Rucinska, Aldona/0000-0002-9578-8894; Litwin,
   Mieczyslaw/0000-0002-5241-2483; Niemirska, Anna/0000-0003-4546-5541
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NR 46
TC 8
Z9 9
U1 0
U2 11
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0931-041X
EI 1432-198X
J9 PEDIATR NEPHROL
JI Pediatr. Nephrol.
PD DEC
PY 2015
VL 30
IS 12
BP 2189
EP 2197
DI 10.1007/s00467-015-3164-9
PG 9
WC Pediatrics; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics; Urology & Nephrology
GA CU9OC
UT WOS:000363872900016
PM 26227630
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Gong, SJ
   Gan, SL
   Zhang, YH
   Zhou, HF
   Zhou, Q
AF Gong, Shijun
   Gan, Shenglian
   Zhang, Yuhua
   Zhou, Haifeng
   Zhou, Quan
TI Gamma-glutamyl transferase to high-density lipoprotein cholesterol ratio
   is a more powerful marker than TyG index for predicting metabolic
   syndrome in patients with type 2 diabetes mellitus
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Article
DE GGT/HDL-C ratio; TyG index; HOMA-IR; insulin resistance; type 2 diabetes
   mellitus; metabolic syndrome
ID INSULIN-RESISTANCE; RISK; SURROGATE; ADULTS
AB PurposeThe prevalence of metabolic syndrome (MetS) is increasing globally and has become a global and national public health problem that cannot be ignored as an independent predictor of cardiovascular events, cancer and all-cause mortality. gamma-glutamyl transferase (GGT) and high-density lipoprotein cholesterol (HDL-C) are associated with insulin resistance, dyslipidemia and oxidative stress. This study was designed to explore the relationship and predictive performance between gamma-glutamyl transferase high-density lipoprotein cholesterol ratio (GGT/HDL-C) and MetS.MethodsThis was a cross-sectional study. MetS was diagnosed from biochemical and anthropometric data in subjects with T2DM. Multivariate logistic regression was used to analyses the relationship between GGT/HDL-C ratio, TyG index and HOMA-IR and MetS in subjects with T2DM. Receiver operating characteristic (ROC) curve was drawn and the areas under the curve (AUC) were used to assess the ability of these indexes in screening MetS in subjects with T2DM. Statistical differences between the AUC values of these indexes were compared. In addition, we performed subgroup analyses and interactions.Results769 (70.55%) patients with T2DM were defined as having MetS. patients with MetS had higher anthropometric values and biochemical indicators compared to those without MetS. Multivariate logistic regression analysis of GGT/HDL-C ratio was an independent risk factor for MetS (Per 1 SD increase, OR = 2.49, 95% CI: 1.51, 4.10). According to ROC curve analysis, the value of GGT/HDL-C ratio in predicting MetS in subjects with T2DM was superior to that of TyG index and HOMA-IR. The best cut-off value for GGT/HDL-C prediction was 19.94.ConclusionsGGT/HDL-C ratio may be an important predictor of MetS in subjects with T2DM, and its predictive power is stronger than that of TyG index and HOMA-IR. The risk of MetS in subjects with T2DM is increased in the presence of a higher GGT/HDL-C ratio.
C1 [Gong, Shijun; Zhang, Yuhua] Jishou Univ, Dept Med, Jishou, Peoples R China.
   [Gan, Shenglian; Zhou, Haifeng] First Peoples Hosp Changde City, Dept Endocrinol, Changde, Peoples R China.
   [Zhou, Quan] First Peoples Hosp Changde City, Dept Sci & Educ, Changde, Peoples R China.
C3 Jishou University
RP Gan, SL (corresponding author), First Peoples Hosp Changde City, Dept Endocrinol, Changde, Peoples R China.
EM ganslghy03@126.com
RI yuanyuan, Li/JEZ-6497-2023
OI Gan, Shenglian/0000-0003-3005-183X
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NR 55
TC 6
Z9 6
U1 0
U2 6
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD OCT 3
PY 2023
VL 14
AR 1248614
DI 10.3389/fendo.2023.1248614
PG 14
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA U4AW1
UT WOS:001084247400001
PM 37854188
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Li, F
   Li, YJ
   Li, QX
   Shi, XN
AF Li, Feng
   Li, Yijia
   Li, Qingxian
   Shi, Xianai
TI Eriobotrya japonica leaf triterpenoid acids ameliorate metabolic
   syndrome in C57BL/6J mice fed with high-fat diet
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Article
DE Eriobotrya japonica leaf triterpenoid acids; Metabolic syndrome;
   High-fat diet; Insulin resistance; Dyslipidemia; Molecular docking
ID INSULIN-RESISTANCE; BIOACTIVE TRITERPENES; COROSOLIC ACID; PPAR-GAMMA;
   INFLAMMATION; DISCOVERY; POTENT; DERIVATIVES; INHIBITOR; MODEL
AB Background: It has been demonstrated in some studies that triterpenoid acid extract fromEriobotrya japonica leaf is beneficial to prevent hyperlipidemia or insulin resistance. However, the effect of triterpenoid acids in Eriobotrya japonica leaf on a series of typical symptoms of metabolic syndrome (MetS) has been rarely studied systemati-cally. Therefore, the present study aims to systematically evaluate the effect of Eriobotrya japonica leaf triterpenoid acids (ELTA) on MetS and explore its potential mechanism.
   Methods: ELTA (HPLC purity 95.2 %) was prepared and administered orally (200 mg/kg) to C57BL/6 J mice fed with a high-fat diet (HFD) for 12 weeks. Pioglitazone (30 mg/kg) was used as a positive control drug. Food intake, body weight, total lipid in feces, lipid profiles, inflammatory factors in serum, hepatic glutathione, and lipid peroxide were measured. Oral glucose tolerance test (OGTT) and insulin tolerance test (ITT) were performed to evaluate insulin sensitivity. RT-qPCR and molecular docking were performed to explore the potential mechanism.
   Results: ELTA administration reduced body weight gain, relative liver weight, and relative visceral adipose weight. The levels of serum total cholesterol, triglycerides, low-density lipoprotein cholesterol, hepatic total cholesterol, and hepatic triglycerides were also reduced. ELTA reduced the area under curve (AUC) of blood glucose curves in OGTT and ITT. Relative mRNA level analysis of genes related to MetS showed that ELTA can effectively increase the transcriptional levels of Nrf2, HO-1, PPAR-gamma, GluT2, GK, FXR, while effectively decrease those of PTP1B, p65, TNF-alpha, IL-6, SREBP, 11 beta HSD-1. Molecular docking showed that the ligands in ELTA can bind to 11 beta HSD-1, GK, PPAR-gamma, and JNK, the important targets involved in MetS.
   Conclusions: ELTA can effectively alleviate visceral central obesity, insulin resistance, dyslipidemia, oxidative stress, and inflammation of HFD-induced MetS in C57BL/6 J mice. This is possibly achieved by acting on 11 beta HSD-1, GK, PPAR-gamma, and JNK.
C1 [Li, Feng; Li, Yijia; Li, Qingxian; Shi, Xianai] Fuzhou Univ, Coll Biol Sci & Engn, Fuzhou 350116, Peoples R China.
   [Li, Feng; Li, Yijia; Li, Qingxian; Shi, Xianai] Fuzhou Univ, Inst Pharmaceut Biotechnol & Engn, Fuzhou 350116, Peoples R China.
   [Li, Feng; Shi, Xianai] Fuzhou Univ, Fujian Key Lab Med Instrument & Pharmaceut Techno, Fuzhou 350108, Fujian, Peoples R China.
C3 Fuzhou University; Fuzhou University; Fuzhou University
RP Li, F (corresponding author), Fuzhou Univ, Coll Biol Sci & Engn, Fuzhou 350116, Peoples R China.
EM lqlchfengli@fzu.edu.cn; shixa@fzu.edu.cn
RI Shi, Xianai/AFV-1485-2022; Li, Qingxian/LIA-9291-2024
OI shi, xian ai/0000-0002-1897-2786; Li, Feng/0000-0003-3574-1186
FU Regional Marine Economic Innovation and Development Demonstration
   Project of Fujian [2014FJ20]
FX The authors wish to respectively thank Professor Meng Chun (Institute of
   Pharmaceutical Biotechnology and Engineering, Fuzhou University) for his
   help and support. This work is sponsored by the Regional Marine Economic
   Innovation and Development Demonstration Project of Fujian (No.
   2014FJ20).
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NR 47
TC 17
Z9 17
U1 1
U2 21
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD DEC
PY 2020
VL 132
AR 110866
DI 10.1016/j.biopha.2020.110866
PG 11
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA OU1GS
UT WOS:000591283900002
PM 33113426
OA gold
DA 2025-06-11
ER

PT J
AU Obata, Y
   Maeda, N
   Yamada, Y
   Yamamoto, K
   Nakamura, S
   Yamaoka, M
   Tanaka, Y
   Masuda, S
   Nagao, H
   Fukuda, S
   Fujishima, Y
   Kita, S
   Nishizawa, H
   Funahashi, T
   Matsubara, K
   Matsuzawa, Y
   Shimomura, I
AF Obata, Yoshinari
   Maeda, Norikazu
   Yamada, Yuya
   Yamamoto, Koji
   Nakamura, Seiji
   Yamaoka, Masaya
   Tanaka, Yoshimitsu
   Masuda, Shigeki
   Nagao, Hirofumi
   Fukuda, Shiro
   Fujishima, Yuya
   Kita, Shunbun
   Nishizawa, Hitoshi
   Funahashi, Tohru
   Matsubara, Ken-ichi
   Matsuzawa, Yuji
   Shimomura, Iichiro
TI Impact of visceral fat on gene expression profile in peripheral blood
   cells in obese Japanese subjects
SO CARDIOVASCULAR DIABETOLOGY
LA English
DT Article
DE Obesity; Visceral fat; Subcutaneous fat; Fat distribution; Gene
   expression; Microarray; Metabolic syndrome; Diabetes; Adiponectin; KLF
ID INSULIN-RESISTANCE; METABOLIC SYNDROME; INFLAMMATION; KLF10;
   ACCUMULATION; ADIPOSE; GUT
AB Background: Visceral fat plays a central role in the development of metabolic syndrome and atherosclerotic cardiovascular diseases. The association of visceral fat accumulation with cardio-metabolic diseases has been reported, but the impact of visceral fat on the gene expression profile in peripheral blood cells remains to be determined. The aim of this study was to determine the effects of visceral fat area (VFA) and subcutaneous fat area (SFA) on the gene expression profile in peripheral blood cells of obese subjects.
   Methods: All 17 enrolled subjects were hospitalized to receive diet therapy for obesity (defined as body mass index, BMI, greater than 25 kg/m(2)). VFA and SFA were measured at the umbilical level by computed tomography (CT). Blood samples were subjected to gene expression profile analysis by using SurePrint G3 Human GE Microarray 8 x 60 k ver. 2.0. The correlation between various clinical parameters, including VFA and SFA, and peripheral blood gene expression levels was analyzed.
   Results: Among the 17 subjects, 12 had normal glucose tolerance or borderline diabetes, and 5 were diagnosed with type 2 diabetes without medications [glycated hemoglobin (HbA1c); 6.3 +/- 1.3%]. The mean BMI, VFA, and SFA were 30.0 +/- 5.5 kg/m(2), 177 +/- 67 and 245 +/- 131 cm(2), respectively. Interestingly, VFA altered the expression of 1354 genes, including up-regulation of 307 and down-regulation of 1047, under the statistical environment that the parametric false discovery rate (FDR) was less than 0.1. However, no significant effects were noted for SFA or BMI. Gene ontology analysis showed higher prevalence of VFA-associated genes than that of SFA-associated genes, among the genes associated with inflammation, oxidative stress, immune response, lipid metabolism, and glucose metabolism.
   Conclusions: Accumulation of visceral fat, but not subcutaneous fat, has a significant impact on the gene expression profile in peripheral blood cells in obese Japanese subjects.
C1 [Obata, Yoshinari; Maeda, Norikazu; Yamaoka, Masaya; Tanaka, Yoshimitsu; Masuda, Shigeki; Nagao, Hirofumi; Fukuda, Shiro; Fujishima, Yuya; Kita, Shunbun; Nishizawa, Hitoshi; Funahashi, Tohru; Shimomura, Iichiro] Osaka Univ, Grad Sch Med, Dept Metab Med, 2-2-B5 Yamada Oka, Suita, Osaka 5650871, Japan.
   [Maeda, Norikazu; Kita, Shunbun; Funahashi, Tohru] Osaka Univ, Grad Sch Med, Dept Metab & Atherosclerosis, 2-2-B5 Yamada Oka, Suita, Osaka 5650871, Japan.
   [Yamada, Yuya; Yamamoto, Koji; Matsuzawa, Yuji] Sumitomo Hosp, Dept Endocrinol & Metab, Kita Ku, 5-3-20 Nakanoshima, Osaka, Osaka 5300005, Japan.
   [Nakamura, Seiji; Matsubara, Ken-ichi] DNA Chip Res Inc, Minato Ku, 1-15-1 Kaigan,Suzuebaydium 5F, Tokyo 1050022, Japan.
C3 The University of Osaka; The University of Osaka; Sumitomo Hospital; DNA
   Chip Research Inc.
RP Maeda, N (corresponding author), Osaka Univ, Grad Sch Med, Dept Metab Med, 2-2-B5 Yamada Oka, Suita, Osaka 5650871, Japan.
EM norikazu_maeda@endmet.med.osaka-u.ac.jp
RI Maeda, Norikazu/LZI-4561-2025; Kawai, Jun/A-6451-2016
OI Nagao, Hirofumi/0009-0001-1261-4160
FU Japan Society for the Promotion of Science (JSPS) [JP25461386,
   JP16K09782, JP26293221]; Takeda Science Foundation; Japan Foundation for
   Applied Enzymology
FX This work was supported in part by the Japan Society for the Promotion
   of Science (JSPS)-Grants-in-Aid for Scientific Research (KAKENHI) #
   JP25461386 (to NM), # JP16K09782 (to MY) and # JP26293221 (to TF),
   Takeda Science Foundation (to NM), and Japan Foundation for Applied
   Enzymology (to YF). The funding agencies had no role in study design,
   data collection and analysis, decision to publish, or preparation of the
   manuscript.
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NR 27
TC 12
Z9 15
U1 0
U2 1
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1475-2840
J9 CARDIOVASC DIABETOL
JI Cardiovasc. Diabetol.
PD NOV 29
PY 2016
VL 15
AR 159
DI 10.1186/s12933-016-0479-1
PG 9
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism
GA EH6NL
UT WOS:000391889700001
PM 27899146
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Tomas, E
   Wood, JA
   Stanojevic, V
   Habener, JF
AF Tomas, Eva
   Wood, Jenna A.
   Stanojevic, Violeta
   Habener, Joel F.
TI GLP-1-derived nonapeptide GLP-1(28-36)amide inhibits weight gain and
   attenuates diabetes and hepatic steatosis in diet-induced obese mice
SO REGULATORY PEPTIDES
LA English
DT Article
DE Glucagon-like peptide-1; Insulin resistance; Obesity; Energy expenditure
ID GLUCAGON-LIKE PEPTIDE-1; MEDIATED GLUCOSE-UPTAKE; GLP-1 9-36 AMIDE;
   NEUTRAL ENDOPEPTIDASE-24.11; INSULIN-RESISTANCE; OXIDATIVE STRESS;
   METABOLITE
AB Background: The metabolic syndrome is an obesity-associated disease manifested as severe insulin resistance, hyperlipidemia, hepatic steatosis, and diabetes. Previously we proposed that a nonapeptide, FIAWLVKGRamide, GLP-1(28-36)amide, derived from the gluco-incretin hormone, glucagon-like peptide-1 (GLP-1), might have insulin-like actions. Recently, we reported that the nonapeptide appears to enter hepatocytes, target to mitochondria, and suppress glucose production and reactive oxygen species. Therefore, the effects of GLP-1 (28-36)amide were examined in diet-induced obese, insulin-resistant mice as a model for the development of human metabolic syndrome.
   Methods and results: Three- to 11-week infusions of GLP-1(28-36)amide were administered via osmopumps to mice fed a very high fat diet (VHFD) and to control mice on a normal low fat diet (LFD). Body weight, DXA, energy intake, plasma insulin and glucose, and liver triglyceride levels were assessed. GLP-1(28-36)amide inhibited weight gain, accumulation of liver triglycerides, and improved insulin sensitivity by attenuating the development of fasting hyperglycemia and hyperinsulinemia in mice fed VHFD. GLP-1(28-36)amide had no observable effects in control LFD mice. Surprisingly, the energy intake of peptide-infused obese mice is 25-70% greater than in obese mice receiving vehicle alone, yet did not gain excess weight.
   Conclusions: GLP-1(28-36)amide exerts insulin-like actions selectively in conditions of obesity and insulin resistance. The peptide curtails weight gain in diet-induced obese mice in the face of an increase in energy intake suggesting increased energy expenditure. These findings suggest utility of GLP-1(28-36)amide, or a peptide mimetic derived there from, for the treatment of insulin resistance and the metabolic syndrome. (C) 2011 Elsevier B.V. All rights reserved.
C1 [Tomas, Eva; Wood, Jenna A.; Stanojevic, Violeta; Habener, Joel F.] Massachusetts Gen Hosp, Mol Endocrinol Lab, Boston, MA 02114 USA.
C3 Harvard University; Harvard University Medical Affiliates; Massachusetts
   General Hospital
RP Habener, JF (corresponding author), Massachusetts Gen Hosp, Mol Endocrinol Lab, Boston, MA 02114 USA.
EM jhabener@partners.org
OI Wood, Jenna/0000-0001-6715-0626
FU Novo Nordisk
FX We thank Zhenghu Liu for helpful comments, Karen McManus for expert
   experimental assistance, and Ashok Khatri for peptide synthesis. The
   later studies were supported in part by a grant from Novo Nordisk.
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NR 27
TC 36
Z9 45
U1 0
U2 6
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0167-0115
EI 1873-1686
J9 REGUL PEPTIDES
JI Regul. Pept.
PD AUG 8
PY 2011
VL 169
IS 1-3
BP 43
EP 48
DI 10.1016/j.regpep.2011.04.006
PG 6
WC Endocrinology & Metabolism; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Physiology
GA 787ID
UT WOS:000292368900007
PM 21549160
DA 2025-06-11
ER

PT J
AU Fusco, C
   Frattini, D
   Pisani, F
   Spaggiari, F
   Ferlini, A
   Della Giustina, E
AF Fusco, Carlo
   Frattini, Daniele
   Pisani, Francesco
   Spaggiari, Federica
   Ferlini, Alessandra
   Della Giustina, Elvio
TI Coexistent Central and Peripheral Nervous System Involvement in a
   Charcot-Marie-Tooth Syndrome X-linked Patient
SO JOURNAL OF CHILD NEUROLOGY
LA English
DT Article
DE Charcot-Marie-Tooth X-linked; electromyography; white matter lesions
ID DISEASE; MUTATIONS; NEUROPATHY; CELLS; GENE
AB A 14-year-old boy with an episode of acute weakness resembling acute demyelinating encephalomyelitis and polyradiculoneuritis after a febrile illness is described. Molecular analysis showed a mutation at codon 164 of the connexin 32 gene. Neuroradiological and neurophysiological follow-up is reported during acute and chronic phases of disease, suggesting that during metabolic stress connexin 32 mutations lead to a loss of normal cellular communication and reversible cell dysfunction in oligodendrocytes and in Schwann cells. These data confirm that altered gating properties of connexin 32 could give rise to acute, transient central and peripheral nervous system symptoms in situations of metabolic stress.
C1 [Fusco, Carlo; Frattini, Daniele; Della Giustina, Elvio] Arcispedale Santa Maria Nuova, Pediat Neurol Unit, I-42100 Reggio Emilia, Italy.
   [Pisani, Francesco] Univ Parma, Dept Pediat, Unit Child Neuropsychiat, I-43100 Parma, Italy.
   [Spaggiari, Federica; Ferlini, Alessandra] Univ Ferrara, Med Genet Sect, Dept Expt & Diagnost Med, I-44100 Ferrara, Italy.
C3 IRCCS Arcispedale S. Maria Nuova; University of Parma; University of
   Ferrara
RP Fusco, C (corresponding author), Arcispedale Santa Maria Nuova, Pediat Neurol Unit, Viale Risorgimento 80, I-42100 Reggio Emilia, Italy.
EM fusco.carlo@asmn.re.it
RI Fusco, Carlo/AAC-7332-2022; Pisani, Francesco/K-3486-2018; FERLINI,
   ALESSANDRA/K-7532-2016
OI Frattini, Daniele/0000-0001-9513-3057; PISANI,
   Francesco/0000-0002-1083-5576; FERLINI, ALESSANDRA/0000-0001-8385-9870;
   fusco, carlo/0000-0001-9321-0952
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NR 13
TC 21
Z9 22
U1 0
U2 3
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0883-0738
J9 J CHILD NEUROL
JI J. Child Neurol.
PD JUN
PY 2010
VL 25
IS 6
BP 759
EP 763
DI 10.1177/0883073809344119
PG 5
WC Clinical Neurology; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pediatrics
GA 600QC
UT WOS:000278001000018
PM 20382840
DA 2025-06-11
ER

PT J
AU Senaphan, K
   Kukongviriyapan, U
   Suwannachot, P
   Thiratanaboon, G
   Sangartit, W
   Thawornchinsombut, S
   Jongjareonrak, A
AF Senaphan, Ketmanee
   Kukongviriyapan, Upa
   Suwannachot, Pisit
   Thiratanaboon, Geerasak
   Sangartit, Weerapon
   Thawornchinsombut, Supawan
   Jongjareonrak, Akkasit
TI Protective effects of rice bran hydrolysates on heart rate variability,
   cardiac oxidative stress, and cardiac remodeling in high fat and high
   fructose diet-fed rats
SO ASIAN PACIFIC JOURNAL OF TROPICAL BIOMEDICINE
LA English
DT Article
AB Objective: To examine the ameliorative effect of rice bran hydrolysates (RBH) on metabolic disorders, cardiac oxidative stress, heart rate variability (HRV), and cardiac structural changes in high fat and high fructose (HFHF)-fed rats. Methods: Male Sprague-Dawley rats were daily fed either standard chow diet with tap water or an HFHF diet with 10% fructose in drinking water over 16 weeks. RBH (500 and 1 000 mg/kg/day) was orally administered to the HFHF-diet-fed rats during the last 6 weeks of the study period. At the end of the treatment, metabolic parameters, oxidative stress, HRV, and cardiac structural changes were examined. Results: RBH administration significantly ameliorated metabolic disorders by improving lipid profiles, insulin sensitivity, and hemodynamic parameters. Moreover, RBH restored HRV, as evidenced by decreasing the ratio of low-frequency to high-frequency power of HRV, a marker of autonomic imbalance. Cardiac oxidative stress was also mitigated after RBH supplementation by decreasing cardiac malondialdehyde and protein carbonyl, upregulating eNOS expression, and increasing catalase activity in the heart. Furthermore, RBH mitigated cardiac structural changes by reducing cardiac hypertrophy and myocardial fibrosis in HFHF-diet-fed rats. Conclusions: The present findings suggest that consumption of RBH may exert cardioprotective effects against autonomic imbalances, cardiac oxidative stress, and structural changes in metabolic syndrome.
C1 [Senaphan, Ketmanee; Suwannachot, Pisit; Thiratanaboon, Geerasak] Khon Kaen Univ, Div Physiol, Fac Vet Med, Khon Kaen 40002, Thailand.
   [Senaphan, Ketmanee; Kukongviriyapan, Upa; Sangartit, Weerapon] Khon Kaen Univ, Cardiovasc Res Grp, Khon Kaen 40002, Thailand.
   [Kukongviriyapan, Upa; Sangartit, Weerapon] Khon Kaen Univ, Fac Med, Dept Physiol, Khon Kaen 40002, Thailand.
   [Thawornchinsombut, Supawan] Khon Kaen Univ, Fac Technol, Dept Food Technol, Khon Kaen 40002, Thailand.
   [Jongjareonrak, Akkasit] Chiang Mai Univ, Fac Agroind, Chiang Mai 50100, Thailand.
C3 Khon Kaen University; Khon Kaen University; Khon Kaen University; Khon
   Kaen University; Chiang Mai University
RP Senaphan, K (corresponding author), Khon Kaen Univ, Div Physiol, Fac Vet Med, Khon Kaen 40002, Thailand.; Senaphan, K (corresponding author), Khon Kaen Univ, Cardiovasc Res Grp, Khon Kaen 40002, Thailand.
EM Ketmse@kku.ac.th
OI Sangartit, Weerapon/0000-0002-5058-2294
FU Young Researcher Development Project of Khon Kaen University
FX This work was financially supported by the Young Researcher Development
   Project of Khon Kaen University, 2018.
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NR 31
TC 3
Z9 3
U1 2
U2 13
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, 400059, INDIA
SN 2221-1691
EI 2588-9222
J9 ASIAN PAC J TROP BIO
JI Asian Pac. Trop. Biomed.
PD MAY
PY 2021
VL 11
IS 5
BP 183
EP 193
DI 10.4103/2221-1691.311754
PG 11
WC Tropical Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Tropical Medicine
GA RN3EI
UT WOS:000640233700001
OA gold
DA 2025-06-11
ER

PT J
AU Arias-Chávez, DJ
   Mailloux-Salinas, P
   Aparicio, JL
   Bravo, G
   Gómez-Viquez, NL
AF Arias-Chavez, David Julian
   Mailloux-Salinas, Patrick
   Aparicio, Jessica Ledesma
   Bravo, Guadalupe
   Gomez-Viquez, Norma Leticia
TI Combined fructose and sucrose consumption from an early age aggravates
   cardiac oxidative damage and causes a dilated cardiomyopathy in SHR rats
SO JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION
LA English
DT Article
DE arterial hypertension; cardiac hypertrophy; dilated cardiomyopathy;
   oxidative stress; CaMKII6; high sucrose diet; high fructose diet
ID METABOLIC SYNDROME; HYPERTENSION; STRESS; CAMKII; INFLAMMATION; OBESITY;
   ASSOCIATION; ACTIVATION
AB Obesity increases the risk of arterial hypertension in young adults and favors an early-onset cardiomyopathy by generating oxidative stress. In this sense, indiscriminate consumption of sucrose and fructose sweetened beverages from early ages causes obesity, however its consequences on the heart when there is a genetic predisposition to develop hypertension are not clear. We compared the effects of sucrose, fructose, and their combination in weanling male spontaneously hypertensive rats to determine the relationship between genetic hypertension, obesity, and consumption of these sugars on the degree of cardiac hypertrophy, oxidative stress and Cat+/calmodulin dependent protein kinase II delta oxidation. Histological, biochemical, and western blot studies were performed 12 weeks after treatment initiation. We found that chronic consumption of sucrose or fructose leads to obesity, exacerbates genetic arterial hypertension-induced metabolic alterations, and increases cardiac oxidative stress, Cat+/calmodulin dependent protein kinase II delta oxidation and cardiac hypertrophy. Nonetheless, when sucrose and fructose are consumed together, metabolic alterations worsen and are accompanied by dilated cardiomyopathy. These data suggest that sucrose and fructose combined consumption starting from maternal weaning in rats with genetic predisposition to arterial hypertension accelerates the progression of cardiomyopathy resulting in an early dilated cardiomyopathy.
C1 [Arias-Chavez, David Julian; Mailloux-Salinas, Patrick; Aparicio, Jessica Ledesma; Bravo, Guadalupe; Gomez-Viquez, Norma Leticia] Inst Politecn Nacl, Ctr Invest & Estudios Avanzados, Dept Farmacobiol, Mexico City, Mexico.
   [Bravo, Guadalupe; Gomez-Viquez, Norma Leticia] Inst Politecn Nacl, Ctr Invest & Estudios Avanzados, Dept Farmacobiol, Calz Tenorios 235 Col Granjas Coapa, Mexico City 14330, Mexico.
C3 CINVESTAV - Centro de Investigacion y de Estudios Avanzados del
   Instituto Politecnico Nacional; Instituto Politecnico Nacional - Mexico;
   CINVESTAV - Centro de Investigacion y de Estudios Avanzados del
   Instituto Politecnico Nacional; Instituto Politecnico Nacional - Mexico
RP Bravo, G; Gómez-Viquez, NL (corresponding author), Inst Politecn Nacl, Ctr Invest & Estudios Avanzados, Dept Farmacobiol, Calz Tenorios 235 Col Granjas Coapa, Mexico City 14330, Mexico.
EM gbravof@yahoo.com
OI Arias Chavez, David Julian/0000-0002-6663-0043
FU CONACYT post-graduate fellowship [456311]
FX The research was supported by CONACYT post-graduate fellowship no.
   456311.
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NR 45
TC 2
Z9 2
U1 1
U2 9
PU JOURNAL CLINICAL BIOCHEMISTRY & NUTRITION
PI KYOTO
PA KYOTO PREFECTURAL UNIV MED, GRAD SCH MEDICAL SCIENCE, DEPT MOLECULAR
   GASTROENTEROLOGY & HEPATOLOGY, KYOTO, 602-8566, JAPAN
SN 0912-0009
EI 1880-5086
J9 J CLIN BIOCHEM NUTR
JI J. Clin. Biochem. Nutr.
PD NOV
PY 2023
VL 73
IS 3
BP 205
EP 213
DI 10.3164/jcbn.23-2
EA AUG 2023
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA Y9VA4
UT WOS:001048673600001
PM 37970552
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Medeiros, ND
   de Abreu, FG
   Colato, AS
   de Lemos, LS
   Ramis, TR
   Dorneles, GP
   Funchal, C
   Dani, C
AF Medeiros, Niara da Silva
   de Abreu, Fabiana Guichard
   Colato, Alana Schraiber
   de Lemos, Leandro Silva
   Ramis, Thiago Rozales
   Dorneles, Gilson Pires
   Funchal, Claudia
   Dani, Caroline
TI Effects of Concurrent Training on Oxidative Stress and Insulin
   Resistance in Obese Individuals
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Article
ID METABOLIC SYNDROME; CARDIORESPIRATORY FITNESS; PHYSICAL-ACTIVITY;
   OXIDANT STRESS; LIPOIC ACID; EXERCISE; OVERWEIGHT; SEDENTARY;
   MECHANISMS; ENDURANCE
AB Obesity is associated with insulin resistance (IR) and increased oxidative stress. Thus, the present study aimed to evaluate anthropometric parameters, IR, and oxidative stress in obese individuals subjected to two types of concurrent training at the same intensity but differing in frequency. Accordingly, 25 individuals were divided into two groups: concurrent training 1 (CT1) (5 d/wk) and concurrent training 2 (CT2) (3 d/wk), both with moderate intensity. Anthropometric parameters, IR, and oxidative stress were analyzed before and after 26 sessions of training. Both groups had reduced body weight and body mass index (p < 0.05), but only CT1 showed lower body fat percentage and increased basal metabolic rate (p < 0.05). Moreover, CT1 had increased HOMA-IR and decreased protein damage (carbonyl level), and CT2 had decreased HOMA-IR and increased lipid peroxidation (TBARS level) (p < 0.05). On the other hand, both training protocols reduced the GPx activity. It can be concluded that both types of concurrent training could be an alternative for lowering body weight and BMI. Also, it was observed that concurrent training, depending on the frequency, can contribute to reducing body fat, oxidative damage (protein oxidation), and IR but can induce oxidative damage to lipids. More studies are needed to elucidate the mechanisms involved.
C1 [Medeiros, Niara da Silva; de Abreu, Fabiana Guichard; Colato, Alana Schraiber; de Lemos, Leandro Silva; Ramis, Thiago Rozales; Dorneles, Gilson Pires; Funchal, Claudia; Dani, Caroline] Ctr Univ Metodista, IPA, BR-90420060 Porto Alegre, RS, Brazil.
C3 Centro Universitario Metodista - IPA
RP Dani, C (corresponding author), Ctr Univ Metodista, IPA, BR-90420060 Porto Alegre, RS, Brazil.
EM carolinedani@yahoo.com.br
RI Dani, Caroline/AAB-5511-2020; Dorneles, Gilson/D-5474-2019; Dorneles,
   Gilson/F-8745-2016; Ramis, Thiago/P-6246-2018
OI Dani, Caroline/0000-0003-0046-7148; Dorneles,
   Gilson/0000-0001-6524-3204; Ramis, Thiago/0000-0002-5252-1209
FU Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES);
   Centro Universitario Metodista, do IPA
FX The authors are grateful to the study participants for their cooperation
   and collaborators for their dedication. The financial support was
   provided by Centro Universitario Metodista, do IPA, and Coordenacao de
   Aperfeicoamento de Pessoal de Nivel Superior (CAPES). Dr. A. Leyva
   helped with English editing of the paper.
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NR 47
TC 19
Z9 20
U1 0
U2 2
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PY 2015
VL 2015
AR 697181
DI 10.1155/2015/697181
PG 6
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA CB8AI
UT WOS:000349850000001
PM 25722796
OA Green Published, hybrid, Green Submitted
DA 2025-06-11
ER

PT J
AU Song, YM
   Lee, K
AF Song, Yun-Mi
   Lee, Kayoung
TI Eating behavior and metabolic syndrome over time
SO EATING AND WEIGHT DISORDERS-STUDIES ON ANOREXIA BULIMIA AND OBESITY
LA English
DT Article
DE Dutch Eating Behavior Questionnaire; Restrained eating behavior;
   Emotional eating behavior; Metabolic syndrome; Sex
ID DIETARY RESTRAINT; GENDER-DIFFERENCES; HEALTHY TWIN; WEIGHT-GAIN;
   ASSOCIATION; PREVALENCE; KOREA; STRESS; FAMILY; MOOD
AB Purpose We evaluated the longitudinal associations between eating behaviors (EB) and risk of metabolic syndrome (MetS). Methods We obtained complete data on EB, assessed using the Dutch Eating Behavior Questionnaire, and MetS components at baseline and follow-up. Participants included 1876 individuals (704 men, 1172 women; mean age, 45.0 +/- 12.8 years) from those participating in the Korean Healthy Twin study. A generalized estimating equation model was applied, with sociodemographic factors, health-related factors, follow-up interval, and EB (baseline and changes over time) as independent factors. Results MetS at baseline was 21.5%, while incident MetS and persistent MetS were 12.0% and 66.6%, respectively, at the 3.13 +/- 1.38 years follow-up period. In men, baseline restrained EB had positive associations with concurrent MetS (odds ratio [95% confidence interval] per 1 point increase in the score, 1.55 [1.33-1.81]) and persistent MetS (1.53 [1.16-2.01]); baseline external EB and change in external EB had positive associations with persistent MetS (1.56 [1.04-2.33], 1.37 [1.01-2.22], respectively). In women, baseline restrained EB had a positive association with concurrent MetS (1.14 [1.01-1.30]); baseline external EB had an inverse association with persistent MetS (0.71[0.52-0.98]); baseline emotional EB had positive associations with concurrent, incident, and persistent MetS (1.23 [1.01-1.50], 2.14 [1.50-3.06], and 1.92 [1.40-2.64], respectively); and change in emotional EB had positive associations with incident and persistent MetS (1.50 [1.05-2.15], 1.62 [1.14-2.29], respectively). Conclusion Higher restrained and external EB, and an increase in external EB in men; and higher restrained and emotional EB, and an increase in emotional EB in women may be associated with increased risk of concurrent, incident, or persistent MetS.
C1 [Song, Yun-Mi] Sungkyunkwan Univ, Dept Family Med, Samsung Med Ctr, Sch Med, Seoul, South Korea.
   [Lee, Kayoung] Inje Univ, Coll Med, Dept Family Med, Busan Paik Hosp, Bokjiro 75, Busan 47392, South Korea.
C3 Sungkyunkwan University (SKKU); Samsung Medical Center; Inje University
RP Lee, K (corresponding author), Inje Univ, Coll Med, Dept Family Med, Busan Paik Hosp, Bokjiro 75, Busan 47392, South Korea.
EM kayoung.fmlky@gmail.com
RI Lee, Kayoung/AAV-1254-2020
OI lee, kayoung/0000-0002-2816-554X
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NR 36
TC 18
Z9 19
U1 1
U2 7
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1124-4909
EI 1590-1262
J9 EAT WEIGHT DISORD-ST
JI Eat. Weight Disord.-Stud. Anorex.
PD JUN
PY 2020
VL 25
IS 3
BP 545
EP 552
DI 10.1007/s40519-019-00640-9
PG 8
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychiatry
GA LS8CB
UT WOS:000536607600003
PM 30715680
DA 2025-06-11
ER

PT J
AU Seo, BY
   Her, ES
AF Seo, Bo Young
   Her, Eun Sil
TI Regional disparities related to cardiovascular diseases and diet quality
   in Korean adults: based on the 2013-2016 Korea National Health and
   Nutrition Examination Survey Data
SO NUTRITION RESEARCH AND PRACTICE
LA English
DT Article
DE Health status disparities; diet; cardiovascular disease
ID METABOLIC SYNDROME; OBESITY; ASSOCIATIONS; GENDER; INDEX; URBAN
AB BACKGROUND/OBJECTIVES: Cardiovascular diseases (CVDs) are the leading cause of death in Koreans, and eating habits, including diet quality, are among the etiologies of these diseases. Recently, various studies on regional health disparities have been conducted. However, there are limited studies on their relationship with nutritional factors. This study aimed to identify the magnitude of regional disparities in diet quality and prevalence of CVD in Korean adults.SUBJECTS/METHODS: This study included 17,646 participants aged >= 20 years from the 7th (2013-2016) Korean National Health and Nutrition Examination Survey. Participants were classified into four groups based on their residential areas: City 1, City 2, City 3, and non -city. Demographic characteristics, health-related factors, body mass index (BMI), metabolic syndrome index, diet quality, and CVD prevalence were evaluated.RESULTS: In terms of demographic characteristics, age (P < 0.001), marital status (P < 0.001), educational level (P < 0.001), and income (P < 0.001) were lower in the non-city category. Health-related factors such as monthly drinking rate (P < 0.01) and mental stress (P < 0.05) were the highest in City 1 and lowest in the non-city group. Conversely, the current smoking rate (P < 0.05), BMI (P < 0.05), and prevalence of metabolic syndrome (P < 0.001) were the highest in the non-city group (P < 0.05). The non-city group also had the highest prevalence of CVDs (35.6%). This group had the lowest diet quality index (68.36 +/- 0.22, P < 0.01), caused by low intake of fruit and calcium, a lack of sodium moderation, and an overall imbalance in the macronutrient and fatty acid ratio. When the diet quality index was increased by 1, the odds ratio for the prevalence of CVDs was reduced by 0.991 (P < 0.001), but this was not the case in all regions.CONCLUSIONS: This study provides useful information and data in identifying and resolving the regional health disparities related to CVD prevalence and implementation of public health nutrition systems.
C1 [Seo, Bo Young; Her, Eun Sil] Changshin Univ, Dept Food & Nutr, Chang Won 51352, South Korea.
   [Her, Eun Sil] Changshin Univ, Dept Food & Nutr, 262 Paryong Ro, Chang Won 51352, South Korea.
RP Her, ES (corresponding author), Changshin Univ, Dept Food & Nutr, 262 Paryong Ro, Chang Won 51352, South Korea.
EM heres@cs.ac.kr
FU Changshin university in 2020;  [Changshin-2020-042]
FX This research was supported by grant from Changshin university in 2020
   (Changshin-2020-042).
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NR 43
TC 0
Z9 0
U1 0
U2 1
PU KOREAN NUTRITION SOC
PI SEOUL
PA 804 KST CTR, 635-4 YEOGSAM-SONG KANGNAM-KU, SEOUL, 135-703, SOUTH KOREA
SN 1976-1457
EI 2005-6168
J9 NUTR RES PRACT
JI Nutr. Res. Pract.
PD DEC
PY 2022
VL 16
IS 6
BP 755
EP 764
DI 10.4162/nrp.2022.16.6.755
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 6O8KA
UT WOS:000890486900006
PM 36467768
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Won, KB
   Chang, HJ
   Mdc, DH
   Sung, J
   Choi, SY
AF Won, Ki-Bum
   Chang, Hyuk-Jae
   Mdc, Donghee Han
   Sung, Jidong
   Choi, Su-Yeon
TI Metabolic syndrome predicts long-term mortality in subjects without
   established diabetes mellitus in asymptomatic Korean population A
   propensity score matching analysis from the Korea Initiatives on
   Coronary Artery Calcification (KOICA) registry
SO MEDICINE
LA English
DT Article
DE diabetes mellitus; metabolic syndrome; mortality
ID CARDIOVASCULAR-DISEASE; OXIDATIVE STRESS; GLUCOSE; ATHEROSCLEROSIS;
   PATHOGENESIS; ASSOCIATION; PREVALENCE; OBESITY
AB Despite the different features of diabetes mellitus (DM) in Asian populations compared with Western populations, the impact of metabolic syndrome (MetS) on long-term mortality according to DM status has not yet been elucidated in the Asian population.
   After performing 1: 1 propensity score matching (PSM) using clinical variables including age, gender, smoking, and individual MetS components between DM and non-DM subjects from the data of the Korea Initiatives on Coronary Artery Calcification registry, mortality was evaluated according to DM and MetS in 14,956 asymptomatic Korean subjects.
   The mean follow-up duration was 53.1 months (interquartile range: 33-80). The overall prevalence of MetS was 60%. DM subjects had higher mortality compared with non-DM subjects (1.2% vs 0.7%, respectively; P=0.001); the cumulative mortality by Kaplan-Meier analysis was higher in DM subjects than in non-DM subjects (log-rank P=0.001). DM increased the risk of mortality in PSM participants (hazard ratio [HR] 1.74; P=0.001). In non-DM subjects, MetS (HR 2.32) and one of its components, central obesity (HR 1.97), were associated with an increased risk of mortality (both P<0.05). In contrast, there was no significant difference in the risk of mortality according to MetS or its components in DM subjects. After adjusting for confounding risk factors, it was shown that MetS independently increased the risk of mortality in non-DM subjects.
   Compared with non-DM subjects, DM subjects have an increased risk of long-term mortality among PSM participants. MetS appears to have an independent impact on mortality in subjects without established DM among the asymptomatic Korean population. Our results may not be applicable to the whole subjects with MetS because the PSM using MetS components was performed between subjects with and without DM which was very high risk for adverse clinical events.
C1 [Won, Ki-Bum] Univ Ulsan, Coll Med, Ulsan Univ Hosp, Dept Internal Med, Ulsan, South Korea.
   [Won, Ki-Bum; Chang, Hyuk-Jae] Yonsei Univ, Coll Med, Severance Biomed Sci Inst, Seoul, South Korea.
   [Chang, Hyuk-Jae; Mdc, Donghee Han] Yonsei Univ, Coll Med, Yonsei Cardiovasc Ctr, Dept Internal Med, Seoul, South Korea.
   [Sung, Jidong] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Internal Med, Seoul, South Korea.
   [Choi, Su-Yeon] Seoul Natl Univ, Seoul Natl Univ Healthcare Syst, Gangnam Ctr, Dept Internal Med,Coll Med, Seoul, South Korea.
C3 University of Ulsan; Ulsan University Hospital; Yonsei University;
   Yonsei University Health System; Yonsei University; Yonsei University
   Health System; Sungkyunkwan University (SKKU); Samsung Medical Center;
   Seoul National University (SNU)
RP Chang, HJ (corresponding author), Yonsei Univ, Coll Med, Yonsei Cardiovasc Ctr, 50 Yonsei Ro, Seoul 120752, South Korea.
EM hjchang@yuhs.ac
RI Choi, Su-Yeon/C-4312-2013; sung, jd/O-5936-2014
OI Chang, Hyuk-Jae/0000-0002-6139-7545
FU Korean Health Technology R&D Project, Ministry of Health and Welfare,
   Republic of Korea [HI13C0715]
FX This work was supported by a grant from the Korean Health Technology R&D
   Project, Ministry of Health and Welfare, Republic of Korea (HI13C0715).
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NR 28
TC 5
Z9 5
U1 0
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD DEC
PY 2016
VL 95
IS 49
AR e5421
DI 10.1097/MD.0000000000005421
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA EF0TW
UT WOS:000390040000018
PM 27930521
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Echahidi, N
   Mohty, D
   Pibarot, P
   Després, JP
   O'Hara, G
   Champagne, J
   Philippon, F
   Daleau, P
   Voisine, P
   Mathieu, P
AF Echahidi, Najmeddine
   Mohty, Dania
   Pibarot, Philippe
   Despres, Jean-Pierre
   O'Hara, Gilles
   Champagne, Jean
   Philippon, Francois
   Daleau, Pascal
   Voisine, Pierre
   Mathieu, Patrick
TI Obesity and metabolic syndrome are independent risk factors for atrial
   fibrillation after coronary artery bypass graft surgery
SO CIRCULATION
LA English
DT Article; Proceedings Paper
CT 79th Annual Scientific Session of the American-Heart-Association
CY NOV 12-15, 2006
CL Chicago, IL
SP Amer Heart Assoc
DE atrial fibrillation; coronary artery bypass grafting; metabolic
   syndrome; obesity
ID OXIDATIVE STRESS; PREDICTORS; MANAGEMENT; OUTCOMES; DISEASE; IMPACT;
   VOLUME; FAT
AB Background - Postoperative atrial fibrillation (POAF) is a highly prevalent complication after cardiac surgery with substantial effects on outcomes. Previous studies have reported that obesity is a risk factor for POAF after cardiac surgery. However, it is unknown whether the metabolic syndrome ( MS) also increases the risk of postoperative atrial fibrillation.
   Methods and Results - We retrospectively analyzed the association between obesity and MS and the incidence of new-onset POAF in a total of 5085 patients who underwent isolated coronary artery bypass grafting surgery with no concomitant valvular surgery. Of these patients, 1468 (29%) were obese ( body mass index >= 30 kg/m(2)) and 2320 (46%) had a MS as defined by the NCEP-ATPIII. POAF occurred in 1374 (27%)of the patients. Obesity was associated (P < 0.001) with increased incidence of POAF in the whole cohort as well as in patients > 50 years old but not in patients > 50 years old. In these patients, MS was the only metabolic factor to be significantly associated with higher incidence of POAF (12% versus 6%, P = 0.01). In > 50-year-old patients, mild (30 <= body mass index < 35 kg/m(2)) and moderate -severe (body mass index >= 35 kg/m(2)) obesity were independently associated with a 1.4-fold (95% CI: 1.10 to 1.71; P = 0.004) and 2.3- fold (95% CI: 1.71 to 3.13; P < 0.0001) increase in the risk of POAF, respectively. In > 50- year-old patients, MS (relative risk [RR]: 2.36; 95% CI: 1.10 to 5.12; P = 0.02) but not obesity was independently associated with POAF.
   Conclusion - This study demonstrates that obesity is a powerful risk factor for the occurrence of POAF after isolated coronary artery bypass grafting surgery in patients older than 50 years. However, in the younger population, this association is not observed and MS is the only metabolic risk factor to be independently associated with POAF.
C1 Univ Laval, Dept Surg, Quebec City, PQ, Canada.
   Univ Laval, Dept Med, Quebec City, PQ, Canada.
   Univ Laval, Dept Social & Prevent Med, Quebec City, PQ, Canada.
C3 Laval University; Laval University; Laval University
RP Mathieu, P (corresponding author), Hop Laval, 2725 Chemin, Ste Foy, PQ G1V 4G5, Canada.
EM patrick.mathieu@chg.ulaval.ca
RI Daleau, Pascal/W-4941-2019; Pibarot, Philippe/ABD-5300-2021; Philippon,
   Francois/NJS-3665-2025
OI elbeshbeshy, dr ibrahim elbeshbeshy/0009-0007-4857-5494
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NR 28
TC 140
Z9 149
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0009-7322
EI 1524-4539
J9 CIRCULATION
JI Circulation
PD SEP 11
PY 2007
VL 116
IS 11
SU S
BP I213
EP I219
DI 10.1161/CIRCULATIONAHA.106.681304
PG 7
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Cardiovascular System & Cardiology
GA 209BY
UT WOS:000249364500031
PM 17846306
OA Bronze
DA 2025-06-11
ER

PT J
AU Ojeda, ML
   Carreras, O
   Nogales, F
AF Ojeda, Maria Luisa
   Carreras, Olimpia
   Nogales, Fatima
TI The Role of Selenoprotein Tissue Homeostasis in MetS Programming: Energy
   Balance and Cardiometabolic Implications
SO ANTIOXIDANTS
LA English
DT Review
DE selenium; selenoprotein; metabolic syndrome; fetal programming;
   cardiovascular disease
ID DIET-INDUCED OBESITY; METABOLIC SYNDROME; OXIDATIVE STRESS;
   GLUTATHIONE-PEROXIDASE; ADIPOSE-TISSUE; DEVELOPMENTAL ORIGINS; SELENIUM
   DEFICIENCY; INSULIN-RESISTANCE; LEPTIN RESISTANCE; MYOCARDIAL-INFARCTION
AB Selenium (Se) is an essential trace element mainly known for its antioxidant, anti-inflammatory, and anti-apoptotic properties, as it is part of the catalytic center of 25 different selenoproteins. Some of them are related to insulin resistance (IR) and metabolic syndrome (MetS) generation, modulating reactive oxygen species (ROS), and the energetic sensor AMP-activated protein kinase (AMPK); they can also regulate the nuclear transcription factor kappa-B (NF-kB), leading to changes in inflammation production. Selenoproteins are also necessary for the correct synthesis of insulin and thyroid hormones. They are also involved in endocrine central regulation of appetite and energy homeostasis, affecting growth and development. MetS, a complex metabolic disorder, can appear during gestation and lactation in mothers, leading to energetic and metabolic changes in their offspring that, according to the metabolic programming theory, will produce cardiovascular and metabolic diseases later in life. However, there is a gap concerning Se tissue levels and selenoproteins' implications in MetS generation, which is even greater during MetS programming. This narrative review also provides an overview of the existing evidence, based on experimental research from our laboratory, which strengthens the fact that maternal MetS leads to changes in Se tissue deposits and antioxidant selenoproteins' expression in their offspring. These changes contribute to alterations in tissues' oxidative damage, inflammation, energy balance, and tissue function, mainly in the heart. Se imbalance also could modulate appetite and endocrine energy balance, affecting pups' growth and development. MetS pups present a profile similar to that of diabetes type 1, which also appeared when dams were exposed to low-Se dietary supply. Maternal Se supplementation should be taken into account if, during gestation and/or lactation periods, there are suspicions of endocrine energy imbalance in the offspring, such as MetS. It could be an interesting therapy to induce heart reprogramming. However, more studies are necessary.
C1 [Ojeda, Maria Luisa; Carreras, Olimpia; Nogales, Fatima] Univ Seville, Fac Pharm, Dept Physiol, Seville 41012, Spain.
C3 University of Sevilla
RP Carreras, O (corresponding author), Univ Seville, Fac Pharm, Dept Physiol, Seville 41012, Spain.
EM ojedamuri11@us.es; olimpia@us.es; fnogales@us.es
RI Ojeda, Luisa/B-8571-2019; Carreras, olimpia/P-9078-2019; Nogales,
   F/B-8562-2019
OI Maria Luisa, Ojeda Murillo/0000-0002-9160-2749; Carreras,
   Olimpia/0000-0002-3858-0165; Nogales, Fatima/0000-0003-4844-2740
FU Andalusian Regional Government [CTS-193, 2017/CTS-193, 2019/CTS-193,
   2021/CTS-193]
FX The research recompiled in this review was funded by Andalusian Regional
   Government for its support to the CTS-193 research group (2017/CTS-193,
   2019/CTS-193, and 2021/CTS-193).
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NR 228
TC 14
Z9 16
U1 0
U2 8
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD FEB
PY 2022
VL 11
IS 2
AR 394
DI 10.3390/antiox11020394
PG 31
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA ZL6OW
UT WOS:000763795600001
PM 35204276
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Ortega-Pacheco, D
   Jiménez-Pérez, MM
   Serafín-López, J
   Juárez-Rojas, JG
   Ruiz-García, A
   Pacheco-García, U
AF Ortega-Pacheco, Diego
   Marcela Jimenez-Perez, Maria
   Serafin-Lopez, Jeanet
   Gabriel Juarez-Rojas, Juan
   Ruiz-Garcia, Arturo
   Pacheco-Garcia, Ursino
TI Vanadyl Sulfate Effects on Systemic Profiles of Metabolic Syndrome in
   Old Rats with Fructose-Induced Obesity
SO INTERNATIONAL JOURNAL OF ENDOCRINOLOGY
LA English
DT Article
ID FATTY LIVER-DISEASE; INSULIN-RESISTANCE; CARDIOVASCULAR RISK;
   DIABETES-MELLITUS; OXIDATIVE STRESS; IN-VIVO; LEPTIN; GLUCOSE;
   INFLAMMATION; DIET
AB Background. Currently, energy obtained from hypercaloric diets has been part of the obesity and type 2 diabetes mellitus (T2DM) epidemics from childhood to old age. Treatment alternatives have been sought from plants, minerals, and trace elements with metabolic effects. Vanadyl sulfate (VS) has been investigated as a hypoglycemic compound in animal and human studies showing effective insulin-mimetic properties. This characteristic encompasses several molecules that have beneficial pleiotropic effects. The aim was to determine the antiobesity, hypoglycemic, and hypolipidemic effects of VS on fructose-induced metabolic syndrome in aged rats. Material and Methods. Five groups of male Wistar rats were made, each with six rats: two groups with normal diet (ND) and three with high-fructose diet (HFD). The first ND group was treated with saline solution (SS), the second with VS; treatment for HFD groups was in the first group with SS, second with VS, and third with metformin. Weight, body mass index (BMI), blood glucose, and lipidic profile were measured; water, food, fructose and energy consumption were also determined. All parameters were compared among groups. Results and Discussion. Although obese rats treated with VS presented anorexia, oligodipsia, and a marked weight loss in the first two weeks. They recovered food and water intake in the third week with a slow recovery of some weight weeks later. VS normalized blood glucose level and decreased triglyceride and insulin levels in obese rats. These results suggest that vanadyl sulfate shows antiobesity, hypoglycemic, and hypolipidemic properties in old obese rats and could be useful as an alternative, additional, and potent preventive treatment for obesity and T2DM control in elderly obese and poorly controlled diabetic patients. Conclusion. VS could play an important role in the treatment of metabolic syndrome, contributing to a decrease in obesity and T2DM, through different ways, such as euglycemia, satiety, weight loss, and lipid profile optimization, among others. However, more research is needed to confirm this suggestion.
C1 [Ortega-Pacheco, Diego] Univ Sierra Sur, Miahuatlan City, State Of Oaxaca, Mexico.
   [Marcela Jimenez-Perez, Maria; Ruiz-Garcia, Arturo; Pacheco-Garcia, Ursino] Inst Nacl Cardiol Ignacio Chavez, Dept Nephrol, Renal Pathophysiol Lab, Mexico City, DF, Mexico.
   [Serafin-Lopez, Jeanet] IPN, ENCB, Dept Immunol, Mexico City, DF, Mexico.
   [Gabriel Juarez-Rojas, Juan] Inst Nacl Cardiol Ignacio Chavez, Dept Endocrinol, Mexico City, DF, Mexico.
C3 National Institute of Cardiology - Mexico; Instituto Politecnico
   Nacional - Mexico; National Institute of Cardiology - Mexico
RP Pacheco-García, U (corresponding author), Inst Nacl Cardiol Ignacio Chavez, Dept Nephrol, Renal Pathophysiol Lab, Mexico City, DF, Mexico.
EM upacheco@yahoo.com.mx
RI Garcia, Antonio/J-2613-2015; Juárez-Rojas, Juan/AAM-9486-2020
OI Ortega-Pacheco, Diego/0000-0001-8011-1875; Jimenez Perez, Maria
   Marcela/0000-0002-3109-763X; Juarez-Rojas, Juan
   Gabriel/0000-0001-8864-2304; SERAFIN LOPEZ, JEANET/0000-0003-2736-2688
FU Instituto Nacional de Cardiologia Ignacio Chavez through the program
   "Fondos del Gasto Directo Autorizado a la Subdireccion de Investigacion
   Basica"
FX This work was supported by a grant from the Instituto Nacional de
   Cardiologia Ignacio Chavez through the program "Fondos del Gasto Directo
   Autorizado a la Subdireccion de Investigacion Basica".
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NR 54
TC 6
Z9 6
U1 0
U2 5
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1687-8337
EI 1687-8345
J9 INT J ENDOCRINOL
JI Int. J. Endocrinol.
PY 2018
VL 2018
AR 5257216
DI 10.1155/2018/5257216
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA HH3KB
UT WOS:000455617300001
PM 30675160
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Rashid, H
   Jali, A
   Akhter, MS
   Abdi, SAH
AF Rashid, Hina
   Jali, Abdulmajeed
   Akhter, Mohammad Suhail
   Abdi, Sayed Aliul Hasan
TI Molecular Mechanisms of Oxidative Stress in Acute Kidney Injury:
   Targeting the Loci by Resveratrol
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE oxidative stress; reactive oxygen species; acute kidney injury;
   mitochondrial dysfunction; resveratrol
ID ISCHEMIA-REPERFUSION INJURY; ELECTRON-TRANSPORT CHAIN; REGULATED
   CELL-DEATH; RENAL INJURY; NITRIC-OXIDE; NLRP3 INFLAMMASOME; METABOLIC
   SYNDROME; GLYCEMIC CONTROL; IN-VITRO; KAPPA-B
AB Reactive oxygen species are a group of cellular molecules that stand as double-edged swords, their good and bad being discriminated by a precise balance. Several metabolic reactions in the biological system generate these molecules that interact with cellular atoms to regulate functions ranging from cell homeostasis to cell death. A prooxidative state of the cell concomitant with decreased clearance of such molecules leads to oxidative stress, which contributes as a prime pathophysiological mechanism in various diseases including renal disorders, such as acute kidney injury. However, targeting the generation of oxidative stress in renal disorders by an antioxidant, resveratrol, is gaining considerable therapeutic importance and is known to improve the condition in preclinical studies. This review aims to discuss molecular mechanisms of oxidative stress in acute kidney injury and its amelioration by resveratrol. The major sources of data were PubMed and Google Scholar, with studies from the last five years primarily included, with significant earlier data also considered. Mitochondrial dysfunction, various enzymatic reactions, and protein misfolding are the major sources of reactive oxygen species in acute kidney injury, and interrupting these loci of generation or intersection with other cellular components by resveratrol can mitigate the severity of the condition.
C1 [Rashid, Hina; Jali, Abdulmajeed] Jazan Univ, Coll Pharm, Dept Pharmacol & Toxicol, Jizan 45142, Saudi Arabia.
   [Akhter, Mohammad Suhail] Jazan Univ, Coll Appl Med Sci, Dept Med Lab Technol, Jizan 45142, Saudi Arabia.
   [Abdi, Sayed Aliul Hasan] Al Baha Univ, Fac Clin Pharm, Dept Pharm, Al Baha 65711, Saudi Arabia.
C3 Jazan University; Jazan University; Al Baha University
RP Rashid, H (corresponding author), Jazan Univ, Coll Pharm, Dept Pharmacol & Toxicol, Jizan 45142, Saudi Arabia.
EM hzehqeer@jazanu.edu.sa
RI Jali, Abdulmajeed/GVT-6518-2022
OI Jali, Abdulmajeed/0000-0002-8844-2385; Abdi, Dr Sayed Aliul
   Hasan/0000-0002-3339-3264
FU Deputyship for Research and Innovation, Ministry of Education in Saudi
   Arabia
FX No Statement Available
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NR 231
TC 19
Z9 20
U1 9
U2 27
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD JAN
PY 2024
VL 25
IS 1
AR 3
DI 10.3390/ijms25010003
PG 27
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA EQ4J4
UT WOS:001140373600001
PM 38203174
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Rowicka, G
   Dylag, H
   Ambroszkiewicz, J
   Riahi, A
   Weker, H
   Chelchowska, M
AF Rowicka, Grazyna
   Dylag, Hanna
   Ambroszkiewicz, Jadwiga
   Riahi, Agnieszka
   Weker, Halina
   Chelchowska, Magdalena
TI Total Oxidant and Antioxidant Status in Prepubertal Children with
   Obesity
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Article
ID OXIDATIVE STRESS STATUS; METABOLIC SYNDROME; CHILDHOOD OBESITY;
   INFLAMMATION; MARKERS; BIOMARKERS; OVERWEIGHT; ENZYMES
AB Aims. Obesity is accompanied by the formation of oxygen free radicals, whose intensified activity without effective defense mechanisms can lead to oxidative stress and related complications. We evaluated the presence of oxidative stress in obese prepubertal children. Methods. The study included 83 healthy children aged 2-10 years (62 with obesity and 21 nonobese controls). Total oxidant capacity (TOC), total antioxidant capacity (TAC), oxidized low-density lipoprotein (ox-LDL), lipid parameters, glucose, and C-reactive protein (CRP) were measured in serum. Oxidative stress index (OSI) was calculated. Results. Serum TOC concentration was significantly higher (p < 0.05) and TAC concentration was lower (p < 0.05) in obese children. OSI was higher (p < 0.01) in obese subjects compared with controls. CRP levels were normal in all children, but median CRP value was higher (p < 0.01) and HDL cholesterol levels were lower (p < 0.05) in the obese group. We found a significant negative correlation between TAC and ox-LDL concentrations (r = -0.27, p < 0.05) in obese children. Furthermore, obesity duration was positively correlated with TOC level (r = 0.32, p < 0.05) in this group. Conclusions. Obesity-related oxidative stress already occurs in prepubescence. Early obesity diagnosis and the necessary therapeutic activity implementation is a vital strategy for the prophylaxis of free radical damage and related multiorgan complications.
C1 [Rowicka, Grazyna; Dylag, Hanna; Riahi, Agnieszka; Weker, Halina] Inst Mother & Child Hlth, Nutr Dept, Warsaw, Poland.
   [Ambroszkiewicz, Jadwiga; Chelchowska, Magdalena] Inst Mother & Child Hlth, Screening Dept, Warsaw, Poland.
RP Rowicka, G (corresponding author), Inst Mother & Child Hlth, Nutr Dept, Warsaw, Poland.
EM grazyna.rowicka@imid.med.pl
RI Weker, Halina/N-3714-2018; Rowicka, Grazyna/N-7180-2018; Chelchowska,
   Magdalena/Y-2951-2018; Ambroszkiewicz, Jadwiga/W-1516-2018
OI Rowicka, Grazyna/0000-0002-0560-9435; Weker, Halina/0000-0002-5072-2066;
   Chelchowska, Magdalena/0000-0002-6174-6813; Ambroszkiewicz,
   Jadwiga/0000-0001-7320-7561
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   World Health Organization, 2009, SCH POL FRAM IMPL WH
NR 34
TC 37
Z9 38
U1 0
U2 2
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PY 2017
VL 2017
AR 5621989
DI 10.1155/2017/5621989
PG 6
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA FE0EI
UT WOS:000407893200001
PM 28904738
OA Green Published, Green Submitted, hybrid
DA 2025-06-11
ER

PT J
AU Wirtz, PH
   Ehlert, U
   Emini, L
   Suter, T
AF Wirtz, Petra H.
   Ehlert, Ulrike
   Emini, Luljeta
   Suter, Tobias
TI Higher body mass index (BMI) is associated with reduced glucocorticoid
   inhibition of inflammatory cytokine production following acute
   psychosocial stress in men
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE BMI; atherosclerosis; stress; glucocorticoid sensitivity; TNF-alpha
ID ACUTE CORONARY SYNDROMES; NECROSIS-FACTOR-ALPHA; ANTICIPATORY COGNITIVE
   STRESS; PITUITARY-ADRENAL AXIS; C-REACTIVE PROTEIN; METABOLIC SYNDROME;
   ADIPOSE-TISSUE; RECEPTOR GENE; MYOCARDIAL-INFARCTION; EMOTIONAL TRIGGERS
AB Background: Body mass index (BMI) and mental stress seem to exert part of their cardiovascular risk by eliciting inflammation. However, the adverse effects of stress on inflammatory activity with BMI are not fully understood. We investigated whether higher BMI is associated with reduced glucocorticoid inhibition of inflammatory cytokine production following stress in men while controlling for age and blood pressure. We measured glucorticoid inhibition of lipopolysaccharide (LPS)-stimulated release of the proinflammatory cytokine tumor necrosis factor (TNF)-alpha.
   Methods: Forty-two men (age range 21-65 years; BMI range 21-34 kg/m(2)) underwent the Trier Social Stress Test (combination of mock job interview and mental arithmetic task). Whole blood samples were taken immediately before and after stress, and during recovery up to 60 min post-stress. Glucocorticoid sensitivity of LPS-stimutated TNF-alpha expression was assessed in vitro with and without coincubating increasing doses of dexamethasone. Moreover, salivary cortisol was measured during the experiment and on a normal day for assessment of baseline circadian cortisol.
   Results: Higher BMI was associated with lower glucocorticoid sensitivity of monocyte TNF-alpha production after stress (main effect of BMI: p < 0.001) and with more pronounced decreases of glucocorticoid sensitivity following stress (interaction of stress-by-BMI: p = 0.002). Neither LPS-stimulated TNF-alpha. release nor baseline glucocorticoid sensitivity were associated with BMI. Similarly, BMI was not associated with salivary cortisol, either in reaction to stress or in circadian cortisol secretion.
   Conclusions: Our data suggest that with increasing BMI, glucocorticoids are less able to inhibit TNF-alpha production following stress. This might suggest a new mechanism linking BMI with elevated risk for adverse cardiovascular outcomes following stress. (c), 2008 Elsevier Ltd. All rights reserved.
C1 [Wirtz, Petra H.; Ehlert, Ulrike; Emini, Luljeta] Univ Zurich, Dept Clin Psychol & Psychotherapy, CH-8050 Zurich, Switzerland.
   [Suter, Tobias] Univ Zurich Hosp, Dept Internal Med, Zurich, Switzerland.
C3 University of Zurich; University of Zurich; University Zurich Hospital
RP Wirtz, PH (corresponding author), Univ Zurich, Dept Clin Psychol & Psychotherapy, Binzmuhlestr 14,Box 26, CH-8050 Zurich, Switzerland.
EM p.wirtz@psychologie.uzh.ch
RI Wirtz, Petra/G-6317-2011
OI Suter, Tobias/0000-0002-5048-2867
FU University of Zurich [56233203]
FX The study was funded by research grant 56233203 from the University of
   Zurich (to P.H.W.).
CR [Anonymous], FEBS LETT
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NR 63
TC 43
Z9 51
U1 0
U2 8
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD SEP
PY 2008
VL 33
IS 8
BP 1102
EP 1110
DI 10.1016/j.psyneuen.2008.05.002
PG 9
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA 353QO
UT WOS:000259583500008
PM 18644679
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Clark, VC
   Marek, G
   Liu, C
   Collinsworth, A
   Shuster, J
   Kurtz, T
   Nolte, J
   Brantly, M
AF Clark, Virginia C.
   Marek, George
   Liu, Chen
   Collinsworth, Amy
   Shuster, Jonathan
   Kurtz, Tracie
   Nolte, Joanna
   Brantly, Mark
TI Clinical and histologic features of adults with alpha-1 antitrypsin
   deficiency in a non-cirrhotic cohort
SO JOURNAL OF HEPATOLOGY
LA English
DT Article
DE Liver cirrhosis; Hepatocytes; Alpha-1 antitrypsin deficiency;
   Prevalence; Risk factors; Metabolic syndrome; Elasticity imaging
   techniques
ID ENDOPLASMIC-RETICULUM STRESS; LIVER-DISEASE; NATURAL-HISTORY;
   ALPHA1-ANTITRYPSIN DEFICIENCY; LUNG; INDIVIDUALS; RISK; PIZZ;
   INVOLVEMENT; CIRRHOSIS
AB Background & Aims: Alpha-1 antitrypsin deficiency (AATD) is an uncommonly recognized cause of liver disease in adults, with descriptions of its natural history limited to case series and patient-reported data from disease registries. Liver pathology is limited to selected patients or unavailable. Therefore, we aimed to determine the prevalence and severity of liver fibrosis in an adult AATD population who were not known to have cirrhosis, while defining risk factors for fibrosis and testing non-invasive markers of disease.
   Methods: A total of 94 adults with classic genotype 'PI*ZZ' AATD were recruited from North America and prospectively enrolled in the study. Liver aminotransferases and markers of synthetic function, transient elastography, and liver biopsy were performed.
   Results: The prevalence of clinically significant liver fibrosis (F >= 2) was 35.1%. Alanine aminotransferase, aspartate aminotransferase and gamma-glutamyltransferase values were higher in the F >= 2 group. Metabolic syndrome was associated with the presence of clinically significant fibrosis (OR 14.2; 95% CI 3.7-55; p < 0.001). Additionally, the presence of accumulated abnormal AAT in hepatocytes, portal inflammation, and hepatocellular degeneration were associated with clinically significant fibrosis. The accuracy of transient elastography to detect F >= 2 fibrosis was fair, with an AUC of 0.70 (95% CI 0.58-0.82).
   Conclusions: Over one-third of asymptomatic and lung affected adults with 'PI*ZZ' AATD have significant underlying liver fibrosis. Liver biopsies demonstrated variable amounts of accumulated Z AAT. The risk of liver fibrosis increases in the presence of metabolic syndrome, accumulation of AAT in hepatocytes, and portal inflammation on baseline biopsy. The results support the hypothesis that liver disease in this genetic condition may be related to a "toxic gain of function" from accumulation of AAT in hepatocytes.
   Lay summary: Individuals diagnosed with classic alpha-1 antitrypsin deficiency (ZZ) are at risk of liver injury and scarring, because of the accumulation of abnormal alpha-1 antitrypsin in the liver. A liver biopsy in ZZ individuals can demonstrate the accumulation of alpha-1 antitrypsin within the liver and identify if any associated liver scarring is present. Indviduals with large amounts of alpha-1 antitrypsin on biopsy may be at risk of liver injury and fibrosis. Additional common medical conditions of diabetes, obesity, high cholesterol, and hypertension (known as metabolic syndrome) are associated with a greater degree of liver injury. (C) 2018 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
C1 [Clark, Virginia C.] Univ Florida, Div Gastroenterol Hepatol & Nutr, Gainesville, FL 32611 USA.
   [Marek, George; Kurtz, Tracie; Nolte, Joanna; Brantly, Mark] Univ Florida, Div Pulm Crit Care & Sleep Med, Gainesville, FL 32611 USA.
   [Liu, Chen; Collinsworth, Amy] Univ Florida, Dept Pathol Immunol & Lab Med, Gainesville, FL 32611 USA.
   [Liu, Chen] Rutgers New Jersey Med Sch, Dept Pathol & Lab Med, Newark, NJ USA.
   [Shuster, Jonathan] Univ Florida, Dept Hlth Outcomes & Policy, Gainesville, FL 32611 USA.
C3 State University System of Florida; University of Florida; State
   University System of Florida; University of Florida; State University
   System of Florida; University of Florida; Rutgers University System;
   Rutgers University New Brunswick; Rutgers University Biomedical & Health
   Sciences; State University System of Florida; University of Florida
RP Clark, VC (corresponding author), 1600 SW Archer Rd,Box 100277,Rm M440, Gainesville, FL 32610 USA.
EM Virginia.clark@medicine.ufl.edu
RI Brantly, Mark/AAH-2922-2020; Li, Jenny/GSD-3780-2022; Clark,
   Virginia/ITU-5002-2023; Shuster, Jonathan/ABB-5773-2021
OI Liu, Chen/0009-0003-0430-6146
FU Fundacion Leopoldo Fernandez Pujals; Clinical and Translational Science
   Institute (CTSI) (NIH National Center for Advancing Translational
   Sciences (NCATS) [UL1 TR000064]; Alpha-1 Foundation
FX This work was supported in part by funding from Fundacion Leopoldo
   Fernandez Pujals in support of Alpha-1 Research as well as the Alpha-1
   Foundation. RedCap Software was used for data collection which is
   supported by the Clinical and Translational Science Institute (CTSI)
   grant support (NIH National Center for Advancing Translational Sciences
   (NCATS) grant UL1 TR000064).
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NR 37
TC 98
Z9 100
U1 0
U2 2
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0168-8278
EI 1600-0641
J9 J HEPATOL
JI J. Hepatol.
PD DEC
PY 2018
VL 69
IS 6
BP 1357
EP 1364
DI 10.1016/j.jhep.2018.08.005
PG 8
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA HA5EU
UT WOS:000450292500019
PM 30138687
DA 2025-06-11
ER

PT J
AU Fang, XY
   Wang, YW
   Chen, Y
   Ren, JJ
   Zhang, C
AF Fang, Xinyu
   Wang, Yewei
   Chen, Yan
   Ren, Juanjuan
   Zhang, Chen
TI Association between IL-6 and metabolic syndrome in schizophrenia
   patients treated with second-generation antipsychotics
SO NEUROPSYCHIATRIC DISEASE AND TREATMENT
LA English
DT Article
DE schizophrenia; interleukin-6; metabolic syndrome; second-generation
   antipsychotics
ID NEUROPSYCHOLOGICAL STATUS; REPEATABLE BATTERY; GENDER-DIFFERENCE;
   OXIDATIVE STRESS; RISK; COGNITION; INFLAMMATION; POPULATION; PREVALENCE;
   COMPONENTS
AB Objective: Second-generation antipsychotics (SGAs) have a high risk of causing metabolic syndrome (MetS). There is accumulating evidence supporting the fact that the activation of inflammatory pathway contributes to the development of MetS and further aggravates cognitive impairment. This study aimed to investigate the relationship between interleukin-6 (IL-6), cognitive function, and MetS in schizophrenia patients treated with SGAs.
   Methods: One hundred and seventy-four patients with schizophrenia using SGAs were divided into MetS and non-MetS group, based on the criteria of the National Cholesterol Education Program's Adult Treatment Panel III. Cognitive function was measured using the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). A total of 138 patients and 29 healthy controls were examined in the plasma IL-6 levels.
   Results: The prevalence of MetS in schizophrenia patients treated with SGAs was 33% in this study. There were no significant differences in cognitive functions (both RBANS total score and subscale score) between MetS and non-Mets patients (P>0.05). Patients with MetS had higher plasma levels of IL-6 compared to non-MetS patients (P=0.019). However, such difference was only found in male patients (male: P=0.012; female: P=0.513). The partial correlational analysis further showed that IL-6 levels were notably negative related to the HDL levels in male schizophrenia patients after age, years of education, body mass index (BMI), age of onset, total disease course, and equal dose of olanzapine were controlled (male: P=0.009; female: P=0.450). In addition, the multiple regression analysis (stepwise model) performed in the male patient subgroup showed that IL-6 (beta =-0.283, t=-2.492, P=0.015) was an independent contributor to the HDL levels. However, the IL-6 was not an independent contributor to the HDL levels in female patients.
   Conclusion: Our findings provide evidence suggesting that the immune-inflammatory effect of IL-6 on SGAs-induced MetS may be in a gender manner.
C1 [Fang, Xinyu; Wang, Yewei; Chen, Yan; Ren, Juanjuan; Zhang, Chen] Shanghai Jiao Tong Univ, Sch Med, Shanghai Mental Hlth Ctr, Schizophrenia Program, 600 Wan Ping Nan Rd, Shanghai, Peoples R China.
C3 Shanghai Jiao Tong University
RP Zhang, C (corresponding author), Shanghai Jiao Tong Univ, Sch Med, Shanghai Mental Hlth Ctr, Schizophrenia Program, 600 Wan Ping Nan Rd, Shanghai, Peoples R China.
EM zhangchen645@gmail.com
RI Fang, Xinyu/IYT-2547-2023
OI Fang, Xinyu/0000-0002-3503-7765
FU National Key Research and Development Program of China [2018YFC1314302];
   National Natural Science Foundation of China [81771450, 81471358];
   Shanghai Science and Technology Commission Foundation [14411969000];
   Shanghai Municipal Education Commission-Gaofeng Clinical Medicine Grant
   Support [20152530]; Shanghai Municipal Commission of Health and Family
   Planning Foundation [201540029]; Shanghai Municipal Commission of Health
   and Family Planning, Key Developing Disciplines [2015ZB0405]
FX We are deeply grateful to all of the patients and healthy controls
   participating in this study as well as to the psychiatrists for their
   help in the recruitment and diagnosis of schizophrenic patients. This
   work was supported by the National Key Research and Development Program
   of China (2018YFC1314302), the National Natural Science Foundation of
   China (81771450, 81471358), the Shanghai Science and Technology
   Commission Foundation (14411969000), the Shanghai Municipal Education
   Commission-Gaofeng Clinical Medicine Grant Support (20152530), the
   Shanghai Municipal Commission of Health and Family Planning Foundation
   (201540029) and the Shanghai Municipal Commission of Health and Family
   Planning, Key Developing Disciplines (2015ZB0405).
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NR 48
TC 23
Z9 23
U1 0
U2 5
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
EI 1178-2021
J9 NEUROPSYCH DIS TREAT
JI Neuropsychiatr. Dis. Treat.
PY 2019
VL 15
BP 2161
EP 2170
DI 10.2147/NDT.S202159
PG 10
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA IM5ST
UT WOS:000478054300001
PM 31534339
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Duarte, MMMF
   Rocha, JBT
   Moresco, RN
   Duarte, T
   Da Cruz, IBM
   Loro, VL
   Schetinger, MRC
AF Duarte, Marta M. M. F.
   Rocha, Joao B. T.
   Moresco, Rafael N.
   Duarte, Thiago
   Da Cruz, Ivana B. M.
   Loro, Vania L.
   Schetinger, Maria R. C.
TI Association between ischemia-modified albumin, lipids and inflammation
   biomarkers in patients with hypercholesterolemia
SO CLINICAL BIOCHEMISTRY
LA English
DT Article
DE Ischemia-modified albumin; Hypercholesterolemia; Inflammation; Oxidative
   stress
ID C-REACTIVE PROTEIN; CORONARY-ARTERY-DISEASE; ACUTE
   MYOCARDIAL-INFARCTION; LOW-DENSITY LIPOPROTEINS; OXIDATIVE STRESS;
   OXIDIZED LDL; EMERGENCY-DEPARTMENT; HEART-DISEASE; METABOLIC SYNDROME;
   MARKERS
AB Objectives: The aim of this study was to evaluate the association between ischemia-modified albumin (IMA), lipids and inflammation biomarkers in patients with hypercholesterolemia, and the possible involvement of IMA in atheromatous plaque development and oxidative stress.
   Design and methods: Glucose, total cholesterol, HDL cholesterol, LDL cholesterol, triglycerides, oxidized LDL (ox-LDL), ox-LDL autoantibodies, high-sensitivity C reactive protein (hs-CRP), and IMA were measured in 37 subjects with hypercholesterolemia and 37 controls.
   Results: Total cholesterol, LDL cholesterol, triglycerides, ox-LDL, ox-LDL autoantibodies, hs-CRP, and IMA were higher in the hypercholesterolemia group, and HDL cholesterol levels were lower in this group. We observed significant correlations between IMA and total cholesterol, LDL cholesterol, ox-LDL antibodies, and hs-CRP levels. Significant correlations were also observed between hs-CRP and total cholesterol, HDL cholesterol, LDL cholesterol, ox-LDL, ox-LDL autoantibodies, and triglycerides.
   Conclusions: Hypercholesterolemia is associated with an increase in inflammatory and oxidative stress biomarkers, and it also reduces the capacity of albumin to bind cobalt owing to ischemia, resulting in an increased IMA. IMA formation appears to be associated with oxidative stress and atheromatous plaque development. (C) 2009 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
C1 [Duarte, Marta M. M. F.; Rocha, Joao B. T.; Da Cruz, Ivana B. M.; Loro, Vania L.; Schetinger, Maria R. C.] Univ Fed Santa Maria, Programa Posgrad Bioquim Toxicol, BR-97105900 Santa Maria, RS, Brazil.
   [Rocha, Joao B. T.; Loro, Vania L.; Schetinger, Maria R. C.] Univ Fed Santa Maria, Dept Quim, Ctr Ciencias Nat & Exatas, BR-97105900 Santa Maria, RS, Brazil.
   [Moresco, Rafael N.] Univ Fed Santa Maria, Dept Anal Clin & Toxicol, Ctr Ciencias Saude, BR-97105900 Santa Maria, RS, Brazil.
   [Duarte, Thiago] Univ Fed Santa Maria, Curso Farm, Ctr Ciencias Saude, BR-97105900 Santa Maria, RS, Brazil.
C3 Universidade Federal de Santa Maria (UFSM); Universidade Federal de
   Santa Maria (UFSM); Universidade Federal de Santa Maria (UFSM);
   Universidade Federal de Santa Maria (UFSM)
RP Schetinger, MRC (corresponding author), Univ Fed Santa Maria, Programa Posgrad Bioquim Toxicol, Ave Roraima 1000, BR-97105900 Santa Maria, RS, Brazil.
EM mariaschetinger@gmail.com
RI Schetinger, Maria/JAC-4640-2023; Moresco, Rafael/K-6118-2017; da Cruz;
   Manica da Cruz, Ivana/G-4329-2012; Rocha, Joao Batista Teixeira
   da/S-6813-2016; Loro, Vania/E-9387-2015
OI Moresco, Rafael/0000-0003-3072-5080; Chitolina Schetinger, Maria
   Rosa/0000-0002-5240-8935; da Cruz; Manica da Cruz,
   Ivana/0000-0003-3008-6899; Rocha, Joao Batista Teixeira
   da/0000-0003-3829-0595; Loro, Vania/0000-0003-2440-8791
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NR 45
TC 127
Z9 134
U1 0
U2 10
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0009-9120
EI 1873-2933
J9 CLIN BIOCHEM
JI Clin. Biochem.
PD MAY
PY 2009
VL 42
IS 7-8
BP 666
EP 671
DI 10.1016/j.clinbiochem.2009.01.010
PG 6
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA 435WI
UT WOS:000265373600018
PM 19318029
DA 2025-06-11
ER

PT J
AU Park, KY
   Kim, B
   Hyun, CK
AF Park, Kun-Young
   Kim, Bobae
   Hyun, Chang -Kee
TI Lactobacillus rhamnosus GG improves glucose tolerance through
   alleviating ER stress and suppressing macrophage activation in db/db
   mice
SO JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION
LA English
DT Article
DE probiotics; type 2 diabetic mice; insulin resistance; ER stress; M1-like
   macrophage activation
ID HIGH-FAT DIET; ENDOPLASMIC-RETICULUM STRESS; INDUCED INSULIN-RESISTANCE;
   UNFOLDED PROTEIN RESPONSE; GUT MICROBIOTA; SKELETAL-MUSCLE; INFLAMMATORY
   RESPONSE; METABOLIC SYNDROME; ACUTE DIARRHEA; OBESITY
AB Although recent studies have reported that Lactobacillus rhamnosus GG (LGG), the most extensively studied probiotic strain, exerts an anti -hyperglycemic effect on several rodent models, the underlying mechanism remains unclear. In this study, twenty male C57BL/KsJdb/db (db/db) mice were divided into 2 groups, LGG-treated and control group, which received a daily dose of LGG (1 x 10(8) CFU per mouse) and PBS orally for 4 weeks, respectively. We observed that glucose tolerance was significantly improved in LGG-treated db/db mice. Insulin-stimulated Akt phosphorylation and GLUT4 translocation were higher in skeletal muscle of LGG-treated mice relative to their controls. It was also observed that LGG treatment caused significant reductions in endoplasmic reticulum (ER) stress in skeletal muscle and M1-like macrophage activation in white adipose tissues. Our results indicate that the anti-diabetic effect of LGG in db/db mice is associated with alleviated ER stress and suppressed macrophage activation, resulting in enhanced insulin sensitivity. These findings suggest a therapeutic potential of probiotics for prevention and treatment of type 2 diabetes.
C1 [Park, Kun-Young; Kim, Bobae; Hyun, Chang -Kee] Handong Global Univ, Sch Life Sci, Pohang 791708, Gyungbuk, South Korea.
C3 Handong Global University
RP Hyun, CK (corresponding author), Handong Global Univ, Sch Life Sci, Pohang 791708, Gyungbuk, South Korea.
EM ckhyun@handong.edu
OI Park, Kun-Young/0000-0003-0425-3286
FU National Research Foundation - Korean Government (MEST) [2012R1A1B
   6003789]
FX This work was supported by the National Research Foundation Grant funded
   by the Korean Government (MEST, 2012R1A1B 6003789).
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NR 45
TC 68
Z9 76
U1 0
U2 28
PU JOURNAL CLINICAL BIOCHEMISTRY & NUTRITION
PI KYOTO
PA KYOTO PREFECTURAL UNIV MED, GRAD SCH MEDICAL SCIENCE, DEPT MOLECULAR
   GASTROENTEROLOGY & HEPATOLOGY, KYOTO, 602-8566, JAPAN
SN 0912-0009
EI 1880-5086
J9 J CLIN BIOCHEM NUTR
JI J. Clin. Biochem. Nutr.
PD MAY 1
PY 2015
VL 56
IS 3
BP 240
EP 246
DI 10.3164/jcbn.14-116
PG 7
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA DB8HU
UT WOS:000368758600012
PM 26060355
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Ann, JY
   Eo, H
   Lim, Y
AF Ann, Ji-Young
   Eo, Hyeyoon
   Lim, Yunsook
TI Mulberry leaves (Morus alba L.) ameliorate obesity-induced
   hepatic lipogenesis, fibrosis, and oxidative stress in high-fat diet-fed
   mice
SO GENES AND NUTRITION
LA English
DT Article
DE Mulberry leaf; Fatty liver; Hepatic lipid metabolism; Liver fibrosis;
   Oxidative stress
ID LIVER-DISEASE; LIPID-ACCUMULATION; INSULIN-RESISTANCE; INDUCED INCREASE;
   FRUIT EXTRACT; PPAR-ALPHA; NRF2; ACID; DEFICIENCY; LEAF
AB Obesity is associated with chronic diseases such as fatty liver, type 2 diabetes, cardiovascular disease, and severe metabolic syndrome. Obesity causes metabolic impairment including excessive lipid accumulation and fibrosis in the hepatic tissue as well as the increase in oxidative stress. In order to investigate the effect of mulberry leaf (Morus alba L.) extract (MLE) on obesity-induced oxidative stress, lipogenesis, and fibrosis in liver, MLE has been gavaged for 12 weeks in high-fat diet (HFD)-induced obese mice. MLE treatment significantly ameliorated LXRa-mediated lipogenesis and hepatic fibrosis markers such as a-smooth muscle actin, while MLE up-regulated lipolysis-associated markers such as lipoprotein lipase in the HFD-fed mice. Moreover, MLE normalized the activities of antioxidant enzymes including heme oxygenase-1 and glutathione peroxidase in accordance with protein levels of 4-hydroxynonenal in the HFD-fed mice. MLE has beneficial effects on obesity-related fatty liver disease by regulation of hepatic lipid metabolism, fibrosis, and antioxidant defense system. MLE supplementation might be a potential therapeutic approach for obesity-related disease including non-alcoholic fatty liver disease.
C1 [Ann, Ji-Young; Eo, Hyeyoon; Lim, Yunsook] Kyung Hee Univ, Dept Food & Nutr, Seoul 130701, South Korea.
C3 Kyung Hee University
RP Lim, Y (corresponding author), Kyung Hee Univ, Dept Food & Nutr, 26 Kyunghee Daero, Seoul 130701, South Korea.
EM ylim@khu.ac.kr
RI Lim, Yunsook/AAI-8996-2020
OI Lim, Yunsook/0000-0002-3408-8595
FU National Research Foundation of Korea - Korean Government
   [NRF-2010-0006624, NRF-2012R1A1A2040217]
FX This research was supported by National Research Foundation of Korea
   Grant funded by Korean Government (NRF-2010-0006624,
   NRF-2012R1A1A2040217).
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NR 52
TC 95
Z9 104
U1 4
U2 51
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1555-8932
EI 1865-3499
J9 GENES NUTR
JI Genes Nutr.
PD NOV
PY 2015
VL 10
IS 6
AR 46
DI 10.1007/s12263-015-0495-x
PG 13
WC Genetics & Heredity; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Genetics & Heredity; Nutrition & Dietetics
GA CY1HI
UT WOS:000366156900008
PM 26463593
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Sharma, VK
   Singh, TG
AF Sharma, Vivek Kumar
   Singh, Thakur Gurjeet
TI Chronic Stress and Diabetes Mellitus: Interwoven Pathologies
SO CURRENT DIABETES REVIEWS
LA English
DT Review
DE Chronic stress; hypothalamic-pituitary-adrenal axis; diabetes;
   glucocorticoids; insulin; inflammation
ID INDUCED INSULIN-RESISTANCE; CORTICOTROPIN-RELEASING FACTOR;
   PITUITARY-ADRENAL AXIS; MITOCHONDRIAL DYSFUNCTION; METABOLIC SYNDROME;
   GLUCOCORTICOIDS; NEUROENDOCRINE; INFLAMMATION; SECRETION; CORTISOL
AB Stress threatens the homeostasis and mobilizes a plethora of adaptive physiological and behavioral changes via the hypothalamic-pituitary-adrenal (HPA) axis and the sympathetic nervous system. The HPA axis influences the pituitary gland, hypothalamus and adrenal gland via a complex set of positive and negative feedback system. The feedback system operates in a well regulated neuroendocrine manner to reestablish the threatened body equilibrium. The HPA axis secreted major product is a glucocorticoid (cortisol) which is kept within a physiologically optimal range and serves to accomplish the various physiological functions crucial for survival. In chronically stressed individuals dishabituation of HPA axis is followed by increased release of glucocorticoids and catecholamines. Higher secretion of glucocorticoids influences glucose metabolism by promoting gluconeogenesis in the liver, suppressing glucose uptake (adipocytes and skeletal muscles), promoting lipolysis in adipocytes, suppressing insulin secretion, inflicting insulin resistance and inflammation. These biological changes alter neuroendocrine mechanisms and lead to maladaptive congregation of events that form the underlying cause of development of Type 2 diabetes (T2D). The currently reviewed evidences advocate that targeting stress mediated hypersecretion of glucocorticoids may be a viable approach for the treatment of T2D and to reinstate glucose homeostasis.
C1 [Sharma, Vivek Kumar; Singh, Thakur Gurjeet] Chitkara Univ, Chitkara Coll Pharm, Rajpura, Punjab, India.
   [Sharma, Vivek Kumar] Govt Coll Pharm, Dept Pharmacol, Shimla 171207, Himachal Prades, India.
C3 Chitkara University, Punjab
RP Singh, TG (corresponding author), Chitkara Univ, Chitkara Coll Pharm, Rajpura, Punjab, India.
EM gurjeet.singh@chitkara.edu.in
RI Sharma, Vivek Kumar/AGZ-3947-2022; Singh, Dr. Thakur
   Gurjeet/AGV-7671-2022
OI sharma, vivek kumar/0000-0003-1678-4180; Singh, Dr. Thakur
   Gurjeet/0000-0003-2979-1590
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NR 121
TC 69
Z9 75
U1 4
U2 24
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1573-3998
EI 1875-6417
J9 CURR DIABETES REV
JI Curr. Diabetes Reviews
PY 2020
VL 16
IS 6
BP 546
EP 556
DI 10.2174/1573399815666191111152248
PG 11
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA MA3JX
UT WOS:000541814700004
PM 31713487
DA 2025-06-11
ER

PT J
AU Rahman, MH
   Jeong, ES
   You, HS
   Kim, CS
   Lee, KJ
AF Rahman, Md. Habibur
   Jeong, Eun-Sook
   You, Hae Sun
   Kim, Cheol-Su
   Lee, Kyu-Jae
TI Redox-Mechanisms of Molecular Hydrogen Promote Healthful Longevity
SO ANTIOXIDANTS
LA English
DT Review
DE aging; molecular hydrogen; reactive oxygen species; oxidative stress;
   therapeutic effects; redox mechanism; antioxidant; longevity
ID CISPLATIN-INDUCED NEPHROTOXICITY; ACUTE LUNG INJURY; RICH WATER;
   OXIDATIVE STRESS; GUT-MICROBIOTA; RAT MODEL; DOUBLE-BLIND; MITOCHONDRIAL
   DYSFUNCTION; PARKINSONS-DISEASE; METABOLIC SYNDROME
AB Age-related diseases represent the largest threat to public health. Aging is a degenerative, systemic, multifactorial and progressive process, coupled with progressive loss of function and eventually leading to high mortality rates. Excessive levels of both pro- and anti-oxidant species qualify as oxidative stress (OS) and result in damage to molecules and cells. OS plays a crucial role in the development of age-related diseases. In fact, damage due to oxidation depends strongly on the inherited or acquired defects of the redox-mediated enzymes. Molecular hydrogen (H-2) has recently been reported to function as an anti-oxidant and anti-inflammatory agent for the treatment of several oxidative stress and aging-related diseases, including Alzheimer's, Parkinson's, cancer and osteoporosis. Additionally, H-2 promotes healthy aging, increases the number of good germs in the intestine that produce more intestinal hydrogen and reduces oxidative stress through its anti-oxidant and anti-inflammatory activities. This review focuses on the therapeutic role of H-2 in the treatment of neurological diseases. This review manuscript would be useful in knowing the role of H-2 in the redox mechanisms for promoting healthful longevity.
C1 [Rahman, Md. Habibur; Jeong, Eun-Sook; Kim, Cheol-Su; Lee, Kyu-Jae] Yonsei Univ, Wonju Coll Med, Dept Convergence Med, Wonju 26426, South Korea.
   [You, Hae Sun] Korea Univ, Anam Hosp, Dept Anesthesiol & Pain Med, Coll Med, Seoul 02841, South Korea.
C3 Yonsei University; Korea University; Korea University Medicine (KU
   Medicine)
RP Lee, KJ (corresponding author), Yonsei Univ, Wonju Coll Med, Dept Convergence Med, Wonju 26426, South Korea.; You, HS (corresponding author), Korea Univ, Anam Hosp, Dept Anesthesiol & Pain Med, Coll Med, Seoul 02841, South Korea.
EM sunhae67@korea.ac.kr; cs-kim@yonsei.ac.kr; medbio@yonsei.ac.kr
RI ; Kim, Cheolsu/ACM-0171-2022
OI Lee, Kyu-Jae/0000-0001-8748-8122; Kim, Cheolsu/0000-0002-9927-9990; You,
   Hae Sun/0000-0002-2403-2256
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NR 174
TC 9
Z9 9
U1 4
U2 20
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD APR 24
PY 2023
VL 12
IS 5
AR 988
DI 10.3390/antiox12050988
PG 19
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA H2XX6
UT WOS:000994659100001
PM 37237854
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU De Bernardo, G
   Riccitelli, M
   Giordano, M
   Proietti, F
   Sordino, D
   Longini, M
   Buonocore, G
   Perrone, S
AF De Bernardo, Giuseppe
   Riccitelli, Marina
   Giordano, Maurizio
   Proietti, Fabrizio
   Sordino, Desiree
   Longini, Mariangela
   Buonocore, Giuseppe
   Perrone, Serafina
TI Rooming-in Reduces Salivary Cortisol Level of Newborn
SO MEDIATORS OF INFLAMMATION
LA English
DT Article
ID HUMAN-FETAL; INFANTS; PRETERM; STRESS; CARE; REACTIVITY; MOOD; RISK
AB Background. Rooming-in practice improves breastfeeding and reduces newborn stress reactivity. When this modality is not available, partial rooming-in after birth can be considered. Salivary cortisol levels (SCLs) are considered reliable biomarkers to indicate stress. Objective. To test the hypothesis that rooming-in duration impacts neonatal stress response in hospitalized newborns. Design/methods. Forty term newborns, enrolled in the Neonatology and Obstetrics Nursing, C.G. Ruesch, Naples, Italy, were divided, according to the mother's choice, into the study (SG; n = 20) and control (CG; n = 20) groups if they received full (24 hs) or partial (14 hs) rooming-in care, respectively. Saliva samples were collected from all babies between 7: 00 a.m. and 8: 00 a.m. of the 3rd day of life by using oral swab. Salivary cortisol levels were measured using an enzyme immunoassay kit (Salimetrics LLC, PA, USA). Results. A statistically significant difference in the SCLs between SG and CG was found (median: 258 ng/dl versus 488.5 ng/dl; p = 0 048). Conclusions. Data support the practice of full rooming-in care compared with partial rooming-in. The rooming-in duration clearly reduces SCLs and likely neonatal stress. These lower SCLs may have long-term positive effects reducing the risk of metabolic syndrome, high blood pressure, and cognitive and behavioural changes.
C1 [De Bernardo, Giuseppe; Giordano, Maurizio] NICU AORN Santobono Pausilipon, Dept Emergency, Naples, Italy.
   [Riccitelli, Marina; Proietti, Fabrizio; Longini, Mariangela; Buonocore, Giuseppe; Perrone, Serafina] Univ Siena, Dept Mol & Dev Med, Siena, Italy.
   [Sordino, Desiree] CG Ruesch, Neonatol & Obstet Nursing, Naples, Italy.
C3 University of Siena
RP Perrone, S (corresponding author), Univ Siena, Dept Mol & Dev Med, Siena, Italy.
EM saraspv@yahoo.it
RI Perrone, Serafina/AAC-2592-2022; De Bernardo, Giuseppe/AEJ-0153-2022;
   Proietti, Fabrizio/K-6389-2016; Buonocore, Giuseppe/U-3873-2019
OI Perrone, Serafina/0000-0001-5478-5657; De Bernardo,
   Giuseppe/0000-0001-5348-6743; Buonocore, Giuseppe/0000-0002-7921-7485;
   Proietti, Fabrizio/0000-0003-2924-9793; Giordano,
   Maurizio/0000-0001-8568-4242
FU EURAIBI (Europe Against Infant Brain Injury) foundation
FX The authors thank EURAIBI (Europe Against Infant Brain Injury)
   foundation for its partial grants.
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NR 25
TC 12
Z9 13
U1 1
U2 7
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 0962-9351
EI 1466-1861
J9 MEDIAT INFLAMM
JI Mediat. Inflamm.
PY 2018
VL 2018
AR 2845352
DI 10.1155/2018/2845352
PG 5
WC Cell Biology; Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Immunology
GA FZ7DZ
UT WOS:000427761000001
PM 29706798
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Toda-Oti, KS
   Stefano, JT
   Cavaleiro, AM
   Carrilho, FJ
   Correa-Gianella, ML
   de Oliveira, CPMD
AF Toda-Oti, Karla Sawada
   Stefano, Jose Tadeu
   Cavaleiro, Ana Mercedes
   Carrilho, Flair Jose
   Correa-Gianella, Maria Lucia
   de Oliveira, Claudia Pinto Marques de Souza
TI Association of UCP3 Polymorphisms with Nonalcoholic
   Steatohepatitis and Metabolic Syndrome in Nonalcoholic Fatty Liver
   Disease Brazilian Patients
SO METABOLIC SYNDROME AND RELATED DISORDERS
LA English
DT Article
DE UCP3; single nucleotide polymorphism; nonalcoholic fatty liver disease;
   nonalcoholic steatohepatitis; metabolic syndrome
ID GAMMA-GLUTAMYL-TRANSFERASE; UNCOUPLING PROTEIN-3 GENE;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; OBESITY; PROGRESSION;
   TRANSPEPTIDASE; EPIDEMIOLOGY; CHOLESTEROL; PREVALENCE
AB Background: We investigated the possible association of uncoupling protein 3 gene (UCP3) single nucleotide polymorphisms (SNPs) with nonalcoholic steatohepatitis (NASH) and metabolic syndrome (MetS) in nonalcoholic fatty liver disease (NAFLD) Brazilian patients.Methods: UCP3 SNPs rs1726745, rs3781907, and rs11235972 were genotyped in 158 biopsy-proven NAFLD Brazilian patients. Statistics was performed with JMP, R, and SHEsis softwares.Results: The TT genotype of rs1726745 was associated with less occurrence of MetS (P = 0.006) and with lower body mass index (BMI) in the entire NAFLD sample (P = 0.01) and in the NASH group (P = 0.02). The rs1726745-T was associated with lower values of AST (P = 0.001), ALT (P = 0.0002), triglycerides (P = 0.01), and total cholesterol (P = 0.02) in the entire NAFLD sample. Between groups, there were lower values of aminotransferases strictly in individuals with NASH (AST, P = 0.002; ALT, P = 0.0007) and with MetS (AST, P = 0.002; ALT, P = 0.001). The rs3781907-G was associated with lower GGT elevation values in the entire NAFLD sample (P = 0.002), in the NASH group (P = 0.004), and with MetS group (P = 0.003) and with protection for advanced fibrosis (P = 0.01). The rs11235972-A was associated with lower GGT values in the entire NAFLD sample (P = 0.006) and in the NASH group (P = 0.01) and with MetS group (P = 0.005), with fibrosis absence (P = 0.01) and protection for advanced fibrosis (P = 0.01). The TAA haplotype was protective for NASH (P = 0.002), and TGG haplotype was protective for MetS (P = 0.01).Conclusion: UCP3 gene variants were associated with protection against NASH and MetS, in addition to lower values of liver enzymes, lipid profile, BMI and, lesser fibrosis severity in the studied population.
C1 [Toda-Oti, Karla Sawada; Carrilho, Flair Jose; de Oliveira, Claudia Pinto Marques de Souza] Univ Sao Paulo, Dept Gastroenterol, Fac Med, Sao Paulo, Brazil.
   [Stefano, Jose Tadeu; Carrilho, Flair Jose; de Oliveira, Claudia Pinto Marques de Souza] Univ Sao Paulo, Hosp Clin HC FMUSP, Dept Gastroenterol & Hepatol, Lab Gastroenterol Clin & Expt LIM 07,Fac Med, Av Dr Eneas Carvalho Aguiar 255,Inst Cent 9159, BR-05403000 Sao Paulo, Brazil.
   [Cavaleiro, Ana Mercedes; Correa-Gianella, Maria Lucia] Univ Sao Paulo, Hosp Clin HC FMUSP, Lab Carboidratos & Radioimunensaio LIM 18, Fac Med, Sao Paulo, Brazil.
   [Correa-Gianella, Maria Lucia] Univ Nove Julho UNINOVE, Programa Posgrad Med, Sao Paulo, Brazil.
C3 Universidade de Sao Paulo; Universidade de Sao Paulo; Universidade de
   Sao Paulo; Universidade Nove de Julho
RP de Oliveira, CPMD (corresponding author), Univ Sao Paulo, Dept Gastroenterol, Fac Med, Sao Paulo, Brazil.; de Oliveira, CPMD (corresponding author), Univ Sao Paulo, Hosp Clin HC FMUSP, Dept Gastroenterol & Hepatol, Lab Gastroenterol Clin & Expt LIM 07,Fac Med, Av Dr Eneas Carvalho Aguiar 255,Inst Cent 9159, BR-05403000 Sao Paulo, Brazil.
EM cpm@usp.br
RI Oliveira, Claudia/D-1216-2014; Correa-Giannella, Maria
   Lúcia/N-3834-2019; STEFANO, JOSE TADEU/AGR-5605-2022; Carrilho,
   Flair/I-3046-2012
OI P Oliveira, Claudia/0000-0002-2848-417X; Correa-Giannella, Maria
   Lucia/0000-0003-3655-4446; Carrilho, Flair Jose/0000-0002-7682-3105;
   Toda-Oti, Karla/0000-0002-9110-1258
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NR 66
TC 3
Z9 3
U1 1
U2 5
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-4196
EI 1557-8518
J9 METAB SYNDR RELAT D
JI Metab. Syndr. Relat. Disord.
PD MAR
PY 2022
VL 20
IS 2
BP 114
EP 123
DI 10.1089/met.2020.0104
EA JAN 2022
PG 10
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA S5XD7
UT WOS:000745633300001
PM 35020496
DA 2025-06-11
ER

PT J
AU Tabrizi, R
   Tamtaji, OR
   Mirhosseini, N
   Lankarani, KB
   Akbari, M
   Dadgostar, E
   Borhani-Haghighi, A
   Peymani, P
   Ahmadizar, F
   Asemi, Z
AF Tabrizi, Reza
   Tamtaji, Omid Reza
   Mirhosseini, Naghmeh
   Lankarani, Kamran B.
   Akbari, Maryam
   Dadgostar, Ehsan
   Borhani-Haghighi, Afshin
   Peymani, Payam
   Ahmadizar, Fariba
   Asemi, Zatollah
TI The effects of statin use on inflammatory markers among patients with
   metabolic syndrome and related disorders: A systematic review and
   meta-analysis of randomized controlled trials
SO PHARMACOLOGICAL RESEARCH
LA English
DT Review
DE Statin use; Inflammatory markers; Meta-analysis; Metabolic syndrome;
   Randomized control trial
ID C-REACTIVE PROTEIN; PERCUTANEOUS CORONARY INTERVENTION; LOW-DOSE
   ATORVASTATIN; CHRONIC HEART-FAILURE; DENSITY-LIPOPROTEIN-CHOLESTEROL;
   POLYCYSTIC-OVARY-SYNDROME; COA REDUCTASE INHIBITORS; LIPID-LOWERING
   THERAPY; OXIDATIVE STRESS; CARDIOVASCULAR-DISEASE
AB Current evidence suggests that statin use decreases the incidence of cardiovascular diseases (CVD) through reducing LDL cholesterol and decreasing inflammation. Metabolic syndrome (MetS) is usually associated with increased inflammatory markers and increased risk of CVD. We conducted a systematic review and meta-analysis to determine the effect of statin use on inflammatory markers including C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and interleukin-1 (IL-1) among patients with MetS and related disorders. PubMed, EMBASE, Web of Science databases, and Cochrane Library were searched for randomized controlled trials (RCTs) through April 2018. Three independent investigators evaluated study eligibilities, extracted data, and assessed study quality using the Cochrane Collaboration risk of bias tool and Jadad's quality scales. Heterogeneity was determined using Cochran's Q statistic and I-square (I-2) test. Based on the heterogeneity results, we pooled data using random-effect or fixed effect models presented as standardized mean differences (SMD) and corresponding 95% confidence intervals (CI). One hundred thirteen RCTs (19,644 patients) were included in our meta-analysis. The pooled results using random effects model showed that statin use statistically significantly decreased CRP level (SMD= -0.97; 95% CI, -1.10, -0.85; P < 0.001; I-2: 95.1%), TNF-alpha (SMD= -1.88; 95% CI, -2.40, -1.38; P < 0.001; I-2: 97.2%), IL-6 (SMD= -1.67; 95% CI, -1.98, -1.34; P < 0.001; I-2: 96.5%), and IL-1 concentrations (SMD= -8.35; 95% CI, -10.49, -6.22; P < 0.001; I-2: 98.4%) among patients with MetS and related disorders. Our meta-analysis showed beneficial effects of statin use on reducing inflammatory markers in patients with MetS and related disorders.
C1 [Tabrizi, Reza; Akbari, Maryam] Shiraz Univ Med Sci, Inst Hlth, Ctr Hlth Policy Res, Student Res Comm, Shiraz, Iran.
   [Tamtaji, Omid Reza] Kashan Univ Med Sci, Physiol Res Ctr, Kashan, Iran.
   [Mirhosseini, Naghmeh] Univ Saskatchewan, Sch Publ Hlth, Saskatoon, SK, Canada.
   [Lankarani, Kamran B.; Peymani, Payam] Shiraz Univ Med Sci, Inst Hlth, Ctr Hlth Policy Res, Shiraz, Iran.
   [Dadgostar, Ehsan] FDA, Halal Res Ctr IRI, Tehran, Iran.
   [Borhani-Haghighi, Afshin] Shiraz Univ Med Sci, Clin Neurol Res Ctr, Shiraz, Iran.
   [Ahmadizar, Fariba] Erasmus Univ, Med Ctr, Dept Epidemiol, Rotterdam, Netherlands.
   [Asemi, Zatollah] Kashan Univ Med Sci, Res Ctr Biochem & Nutr Metab Dis, Kashan, Iran.
C3 Shiraz University of Medical Science; University of Saskatchewan; Shiraz
   University of Medical Science; Shiraz University of Medical Science;
   Erasmus University Rotterdam; Erasmus MC
RP Asemi, Z (corresponding author), Kashan Univ Med Sci, Res Ctr Biochem & Nutr Metab Dis, Kashan, Iran.
EM kmsrc89@gmail.com; tamtaji.or@gmail.com; namirhossini@gmail.com;
   lankaran@sums.ac.ir; m.akbari45@yahoo.com; ehsandadgostar71@gmail.com;
   neuro.ab@gmail.com; peymani.payam@gmail.com; f.ahmadizar@erasmusmc.nl;
   asemi_z@Kaums.ac.ir
RI Borhani-Haghighi, Afshin/AEB-1509-2022; peymani, payam/S-7386-2017;
   Akbari, Ali/G-6044-2016; Tabrizi, Reza/AAC-2486-2021; tamtaji,
   M/KWU-3655-2024; Ahmadizar, Fariba/KXQ-6746-2024; Mirhosseini,
   Naghmeh/AAC-7730-2019; Lankarani, Kamran/P-5336-2019; asemi,
   zatollah/J-2677-2018
OI Tamtaji, Omid Reza/0000-0003-2492-3996; dadgostar,
   ehsan/0000-0002-4041-7324; tabrizi, reza/0000-0001-7634-3948; Borhani
   Haghighi, Afshin/0000-0002-4131-7990
FU Shiraz University of Medical Sciences (SUMS) [97-01-106-17583]
FX The research grant provided by Research Deputy of Shiraz University of
   Medical Sciences (SUMS) with grant number 97-01-106-17583.
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NR 135
TC 36
Z9 37
U1 0
U2 13
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 1043-6618
EI 1096-1186
J9 PHARMACOL RES
JI Pharmacol. Res.
PD MAR
PY 2019
VL 141
BP 85
EP 103
DI 10.1016/j.phrs.2018.12.010
PG 19
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA HO5VT
UT WOS:000460997000008
PM 30576798
DA 2025-06-11
ER

PT J
AU Fülöp, P
   Seres, I
   Lorincz, H
   Harangi, M
   Somodi, S
   Paragh, G
AF Fueloep, Peter
   Seres, Ildiko
   Lorincz, Hajnalka
   Harangi, Mariann
   Somodi, Sandor
   Paragh, Gyoergy
TI Association of chemerin with oxidative stress, inflammation and
   classical adipokines in non-diabetic obese patients
SO JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
LA English
DT Article
DE obesity; chemerin; leptin; adiponectin; oxidized low-density
   lipoprotein; paraoxonase-1; inflammation
ID LOW-DENSITY-LIPOPROTEIN; CHERRY SEED EXTRACT; SERUM PARAOXONASE;
   METABOLIC SYNDROME; LEPTIN CONCENTRATIONS; PLASMA ADIPONECTIN;
   NORMAL-WEIGHT; INHIBITION; EXPRESSION; RISK
AB The prevalence of obesity has been increasing worldwide. Chemerin is a recently discovered adipokine secreted by the enlarged adipose tissue with diverse biological effects that are not well detailed yet. This study aimed to elucidate the potential role of chemerin in oxidative stress and inflammation that are characteristics for excess weight and may eventually lead to insulin resistance and atherosclerotic complications. We also analysed the associations between chemerin and classical adipokines, namely leptin and adiponectin. Therefore, we investigated non-diabetic obese patients without manifest cardiovascular disease and compared their data to healthy lean individuals. Chemerin correlated positively with markers of oxidative stress and inflammation, while it showed a negative correlation with the measure of antioxidant status, characterized by the HDL-linked paraoxonase-1 enzyme. Chemerin also correlated positively with leptin and negatively with adiponectin respectively. In our study population, oxidized low-density lipoprotein and high-sensitivity C-reactive protein were found to be the strongest predictors of chemerin level. We conclude that chemerin may contribute to chronic inflammation and increased oxidative stress in obese individuals, even in the absence of manifest insulin resistance.
C1 [Fueloep, Peter; Seres, Ildiko; Lorincz, Hajnalka; Harangi, Mariann; Somodi, Sandor; Paragh, Gyoergy] Univ Debrecen, Div Metab Dis, Dept Internal Med, Med & Hlth Sci Ctr, H-4032 Debrecen, Hungary.
C3 University of Debrecen
RP Paragh, G (corresponding author), Univ Debrecen, Div Metab Dis, Dept Internal Med, Med & Hlth Sci Ctr, Nagyerdei Krt 98, H-4032 Debrecen, Hungary.
EM paragh@belklinika.com
RI Harangi, Mariann/ACY-2278-2022
OI Harangi, Mariann/0000-0001-9761-9595; Lorincz,
   Hajnalka/0009-0000-5303-3082; Somodi, Sandor/0000-0002-3615-2300
FU Hungarian Scientific Research Fund [OTKA 84196]; European Union;
   European Social Fund;  [TAMOP-4.2.2.A-11/1/KONV-2012-0031]
FX The work is supported by a grant from the Hungarian Scientific Research
   Fund (OTKA 84196) and by the TAMOP-4.2.2.A-11/1/KONV-2012-0031 project.
   The TAMOP project is co-financed by the European Union and the European
   Social Fund.
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NR 52
TC 55
Z9 61
U1 0
U2 26
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
EI 1582-4934
J9 J CELL MOL MED
JI J. Cell. Mol. Med.
PD JUL
PY 2014
VL 18
IS 7
BP 1313
EP 1320
DI 10.1111/jcmm.12282
PG 8
WC Cell Biology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Research & Experimental Medicine
GA AN2KI
UT WOS:000340413500008
PM 24702860
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Anraku, M
   Fujii, T
   Kondo, Y
   Kojima, E
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   Tsuchiya, D
   Goromaru, T
   Tsutsumi, H
   Kadowaki, D
   Maruyama, T
   Otagiri, M
   Tomida, H
AF Anraku, Makoto
   Fujii, Takeshi
   Kondo, Yuko
   Kojima, Eijiro
   Hata, Toshiyuki
   Tabuchi, Norihiko
   Tsuchiya, Daiju
   Goromaru, Takeshi
   Tsutsumi, Hiroyuki
   Kadowaki, Daisuke
   Maruyama, Toru
   Otagiri, Masaki
   Tomida, Hisao
TI Antioxidant properties of high molecular weight dietary chitosan in
   vitro and in vivo
SO CARBOHYDRATE POLYMERS
LA English
DT Article
DE Chitosan; Antioxidant; Human serum albumin; Oxidative stress; Binding
ID OXIDATIVE STRESS; SERUM-ALBUMIN; PLASMA-LIPIDS; ABSORPTION; REDUCTION;
   ACID; SUPPLEMENTATION
AB The effect of high molecular weight chitosan supplement (HMCS) a natural polymer derived from chitin on indices of oxidative stress was investigated in normal volunteers The use of HMCS for 8 weeks resulted in a significant decrease in total cholesterol levels and atherogenic index and increased levels of high density lipoprotein (HDL) cholesterol HMCS treatment also resulted in a lowered ratio of oxidized to reduced albumin and an increase in total plasma antioxidant activity A good correlation between the atherogenic index and oxidized albumin ratio was found The results suggest that the ratio of oxidized to reduced albumin ratio represents a potentially useful marker of the metabolic syndrome In in vitro studies HMCS slightly reduced the levels of two stable radicals in a dose- and time-dependent manner The strong binding capacity of indoxyl sulfate and low density lipoprotein (LDL) cholesterol was also observed with HMCS These results suggest that HMCS reduces significant levels of pro-oxidants such as cholesterol and uremic toxins in the gastrointestinal tract thereby inhibiting the subsequent development of oxidative stress in the systemic circulation in humans (C) 2010 Elsevier Ltd All rights reserved
C1 [Anraku, Makoto] Fukuyama Univ, Dept Phys Pharmaceut, Fac Pharm & Pharmaceut Sci, Fukuyama, Hiroshima 7290292, Japan.
   [Maruyama, Toru; Otagiri, Masaki] Kumamoto Univ, Grad Sch Pharmaceut Sci, Kumamoto 8620973, Japan.
C3 Fukuyama University; Kumamoto University
RP Anraku, M (corresponding author), Fukuyama Univ, Dept Phys Pharmaceut, Fac Pharm & Pharmaceut Sci, 1 Gakuen Chou Sanzo, Fukuyama, Hiroshima 7290292, Japan.
RI Anraku, Makoto/AAA-3935-2020; Maruyama, Toru/NFS-8627-2025
OI Tsutsumi, Hiroyuki/0000-0002-9681-2139; Kadowaki,
   Daisuke/0000-0001-5166-7145
FU Grants-in-Aid for Scientific Research [23790211] Funding Source: KAKEN
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NR 33
TC 56
Z9 58
U1 0
U2 25
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0144-8617
EI 1879-1344
J9 CARBOHYD POLYM
JI Carbohydr. Polym.
PD JAN 10
PY 2011
VL 83
IS 2
BP 501
EP 505
DI 10.1016/j.carbpol.2010.08.009
PG 5
WC Chemistry, Applied; Chemistry, Organic; Polymer Science
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Polymer Science
GA 696JF
UT WOS:000285437000025
DA 2025-06-11
ER

PT J
AU Bessone, F
   Razori, MV
   Roma, MG
AF Bessone, Fernando
   Valeria Razori, Maria
   Roma, Marcelo G.
TI Molecular pathways of nonalcoholic fatty liver disease development and
   progression
SO CELLULAR AND MOLECULAR LIFE SCIENCES
LA English
DT Review
DE Nonalcoholic fatty liver disease; Nonalcoholic steatohepatitis;
   Lipotoxicity; Oxidative stress; Liver fibrosis; Hepatocellular death
ID HEPATIC STELLATE CELLS; ENDOPLASMIC-RETICULUM STRESS; CHAPERONE-MEDIATED
   AUTOPHAGY; NECROSIS-FACTOR-ALPHA; MITOCHONDRIAL PERMEABILITY TRANSITION;
   UNFOLDED PROTEIN RESPONSE; TOLL-LIKE RECEPTORS; INSULIN-RESISTANCE;
   OXIDATIVE STRESS; ADIPOSE-TISSUE
AB Nonalcoholic fatty liver disease (NAFLD) is a main hepatic manifestation of metabolic syndrome. It represents a wide spectrum of histopathological abnormalities ranging from simple steatosis to nonalcoholic steatohepatitis (NASH) with or without fibrosis and, eventually, cirrhosis and hepatocellular carcinoma. While hepatic simple steatosis seems to be a rather benign manifestation of hepatic triglyceride accumulation, the buildup of highly toxicfree fatty acids associated with insulin resistance-induced massive free fatty acid mobilization from adipose tissue and the increased de novo hepatic fatty acid synthesis from glucose acts as the first hit for NAFLD development. NAFLD progression seems to involve the occurrence of parallel, multiple-hit injuries, such as oxidative stress-induced mitochondrial dysfunction, endoplasmic reticulum stress, endotoxin-induced, TLR4-dependent release of inflammatory cytokines, and iron overload, among many others. These deleterious factors are responsible for the triggering of a number of signaling cascades leading to inflammation, cell death, and fibrosis, the hallmarks of NASH. This review is aimed at integrating the overwhelming progress made in the characterization of thephysiopathological mechanisms of NAFLD at a molecular level, to better understand the factor influencing the initiation and progression of the disease.
C1 [Bessone, Fernando] Univ Nacl Rosario, Hosp Prov Centenario, Fac Ciencias Med, Serv Gastroenterol & Hepatol, Rosario, Santa Fe, Argentina.
   [Valeria Razori, Maria; Roma, Marcelo G.] Univ Nacl Rosario, Inst Fisiol Expt IFISE CONICET, Fac Ciencias Bioquim & Farmaceut, Suipacha 570, RA-2000 Rosario, Santa Fe, Argentina.
C3 National University of Rosario; National University of Rosario; Consejo
   Nacional de Investigaciones Cientificas y Tecnicas (CONICET)
RP Roma, MG (corresponding author), Univ Nacl Rosario, Inst Fisiol Expt IFISE CONICET, Fac Ciencias Bioquim & Farmaceut, Suipacha 570, RA-2000 Rosario, Santa Fe, Argentina.
EM mroma@fbioyf.unr.edu.ar
OI Razori, Maria Valeria/0000-0002-2518-119X; Roma, Marcelo
   Gabriel/0000-0002-1660-9801
FU ANPCyT [PICT-2016-1613] Funding Source: Medline
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NR 283
TC 438
Z9 488
U1 14
U2 300
PU SPRINGER BASEL AG
PI BASEL
PA PICASSOPLATZ 4, BASEL, 4052, SWITZERLAND
SN 1420-682X
EI 1420-9071
J9 CELL MOL LIFE SCI
JI Cell. Mol. Life Sci.
PD JAN
PY 2019
VL 76
IS 1
BP 99
EP 128
DI 10.1007/s00018-018-2947-0
PG 30
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA HG9YA
UT WOS:000455367100007
PM 30343320
OA Green Published
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Butkowski, EG
   Jelinek, HF
AF Butkowski, Eugene G.
   Jelinek, Herbert F.
TI Hyperglycaemia, oxidative stress and inflammatory markers
SO REDOX REPORT
LA English
DT Article
DE Type 2 diabetes mellitus; impaired fasting glucose; prediabetes;
   cardiovascular disease; oxidative stress; risk factors; body mass index;
   glutathione; glutathione disulphide; 8-hydroxy-2 '-deoxyguanosine;
   interleukin 1 beta; interleukin-6; interleukin 10; monocyte
   chemoattractant protein 1; insulin like growth factor 1
ID METABOLIC SYNDROME; INSULIN-RESISTANCE; PROINFLAMMATORY CYTOKINES;
   CARDIOVASCULAR-DISEASE; GLUTATHIONE SYNTHESIS; INTERLEUKIN-10 RATIO;
   GLYCEMIC CONTROL; URINARY 8-OHDG; DNA-DAMAGE; HIGH-RISK
AB Introduction: The increasing prevalence of hyperglycaemia implicates a state of oxidative stress and inflammation. Traditional and emerging biomarkers associated with increasing hyperglycaemia were assessed to clarify their role they play in hyperglycaemia.
   Results: 309 participants attending a rural diabetic screening program were categorised into control and quintile groups based upon glucose levels: 1st quintile - <4.5mmol/L and 4th, 5th quintile - >6.1mmol/L. Significant results were obtained for anthropometric data and biochemical markers - glucose, HbA1c and total cholesterol (P<0.001); oxidative stress: glutathione (P<0.001), glutathione:glutathione disulfide and 8-hydroxy-2-deoxyguanosine (P<0.05). Interleukin -1 beta and inflammatory marker ratios IL-6/IL-10, IL-1 beta/IL-10, MCP-1/IL-10, IGF-1/IL-10 and IL-6/IL-1 beta were significant (P<0.05).
   Conclusion: This study provided further evidence that inflammatory and oxidative stress biomarkers may contribute to diagnostic information associated with preclinical increases in BGL. Further we have provided a unique study in the analysis of ratios of inflammatory biomarkers and correlations with increasing BGL.
C1 [Butkowski, Eugene G.; Jelinek, Herbert F.] Charles Sturt Univ, Sch Community Hlth, Albury, NSW, Australia.
   [Jelinek, Herbert F.] Univ New South Wales, Sch Med, Sydney, NSW, Australia.
   [Jelinek, Herbert F.] Macquarie Univ, Fac Med & Hlth Sci, Sydney, NSW, Australia.
C3 Charles Sturt University; University of New South Wales Sydney;
   Macquarie University
RP Butkowski, EG (corresponding author), Charles Sturt Univ, Sch Community Hlth, Albury, NSW, Australia.
EM ebutkowski@csu.edu.au
RI Jelinek, Herbert/S-6779-2019
OI Jelinek, Herbert F/0000-0001-5457-6193
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NR 66
TC 62
Z9 63
U1 0
U2 5
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1351-0002
EI 1743-2928
J9 REDOX REP
JI Redox Rep.
PY 2017
VL 22
IS 6
BP 257
EP 264
DI 10.1080/13510002.2016.1215643
PG 8
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA FL2KP
UT WOS:000414044500004
PM 28277069
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Rocha, HNM
   Teixeira, GF
   Batista, GMS
   Storch, AS
   Garcia, VP
   Mentzinger, J
   Gomes, EAC
   Campos, MO
   Nobrega, ACL
   Rocha, NG
AF Rocha, Helena N. M.
   Teixeira, Gabriel F. F.
   Batista, Gabriel M. S.
   Storch, Amanda S. S.
   Garcia, Vinicius P. P.
   Mentzinger, Juliana
   Gomes, Erika A. C.
   Campos, Monique O. O.
   Nobrega, Antonio C. L.
   Rocha, Natalia G.
TI AT1R blocker prevents mental stress induced retrograde blood flow in
   overweight/obese men
SO PHYSIOLOGICAL REPORTS
LA English
DT Article
DE blood flow; endothelin-1; mental stress; nitric oxide; obesity; shear
   rate
ID ENDOTHELIAL DYSFUNCTION; METABOLIC SYNDROME; OXIDE; MECHANISMS; HEALTHY;
   OBESITY; CELLS
AB The main goal was to determine the impact of mental stress (MS) on blood flow regulation in overweight/obese men. Fourteen overweight/obese men (27 +/- 7 years; 29.8 +/- 2.6 kg/m(2)) participated in two randomized experimental sessions with oral administration of the AT1R blocker Olmesartan (40 mg; AT1RB) or placebo (PL). After 2 h, a 5-min acute MS session (Stroop Color Word Test) was administered. Blood flow was assessed at baseline and during the first 3 min of MS by vascular ultrasound in the brachial artery. Blood was collected before (baseline) and during mental stress (MS) for measurement of nitrite (chemiluminescence) and endothelin-1 (ELISA kit). The AT1R blocker was able to reverse the MS responses observed in the placebo session for retrograde flow (p < 0.01), retrograde SR (p < 0.01) and oscillatory shear index (p = 0.01). Regarding vasoactive substances, no differences were observed in ET-1 (p > 0.05) responses to MS between experimental sessions. However, for nitrite responses, the administration of the AT1R blocker was able to increase circulating levels of NO (p = 0.03) Blockade of AT1R appears to prevent the decrease in endothelial function by reducing low shear stress and maintaining the vasoactive substances balance after MS in overweight/obese men.
C1 [Rocha, Helena N. M.; Teixeira, Gabriel F. F.; Batista, Gabriel M. S.; Storch, Amanda S. S.; Garcia, Vinicius P. P.; Mentzinger, Juliana; Gomes, Erika A. C.; Campos, Monique O. O.; Nobrega, Antonio C. L.; Rocha, Natalia G.] Fluminense Fed Univ, Dept Physiol & Pharmacol, Lab Exercise Sci, Niteroi, Brazil.
   [Rocha, Helena N. M.; Teixeira, Gabriel F. F.; Batista, Gabriel M. S.; Storch, Amanda S. S.; Garcia, Vinicius P. P.; Mentzinger, Juliana; Rocha, Natalia G.] Fluminense Fed Univ, Dept Physiol & Pharmacol, Lab Integrat Cardiometabol, Niteroi, Brazil.
   [Rocha, Helena N. M.; Batista, Gabriel M. S.; Storch, Amanda S. S.; Garcia, Vinicius P. P.; Gomes, Erika A. C.; Campos, Monique O. O.; Nobrega, Antonio C. L.; Rocha, Natalia G.] Fluminense Fed Univ, Natl Inst Sci & Technol INCT Phys In act & Exercis, Natl Council Sci & Technol Dev CNPq, Niteroi, Brazil.
   [Rocha, Natalia G.] Fluminense Fed Univ, Dept Physiol & Pharmacol, Lab Exercise Sci, Rua Alameda Barros Terra,Sala 110,Sao Domingos Nit, BR-24020150 Niteroi, RJ, Brazil.
C3 Universidade Federal Fluminense; Universidade Federal Fluminense;
   Universidade Federal Fluminense; Universidade Federal Fluminense
RP Rocha, NG (corresponding author), Fluminense Fed Univ, Dept Physiol & Pharmacol, Lab Exercise Sci, Rua Alameda Barros Terra,Sala 110,Sao Domingos Nit, BR-24020150 Niteroi, RJ, Brazil.
EM nataliagalito@id.uff.br
RI Rocha, Natalia/AAN-7903-2020; Rocha, Helena/B-9530-2018
OI Fernandes Teixeira, Gabriel/0000-0002-7078-1880; Rocha,
   Helena/0000-0002-4741-7343; Batista, Gabriel/0000-0002-1542-5242
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NR 36
TC 2
Z9 2
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2051-817X
J9 PHYSIOL REP
JI PHYSIOL. REP.
PD JAN
PY 2023
VL 11
IS 1
AR e15566
DI 10.14814/phy2.15566
PG 8
WC Physiology
WE Emerging Sources Citation Index (ESCI)
SC Physiology
GA 7T5BC
UT WOS:000911459500001
PM 36636769
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Kato, J
   Shirakami, Y
   Yamaguchi, K
   Mizutani, T
   Ideta, T
   Nakamura, H
   Ninomiya, S
   Kubota, M
   Sakai, H
   Ibuka, T
   Tanaka, T
   Shimizu, M
AF Kato, Junichi
   Shirakami, Yohei
   Yamaguchi, Kimihiro
   Mizutani, Taku
   Ideta, Takayasu
   Nakamura, Hiroshi
   Ninomiya, Soranobu
   Kubota, Masaya
   Sakai, Hiroyasu
   Ibuka, Takashi
   Tanaka, Takuji
   Shimizu, Masahito
TI Allopurinol Suppresses Azoxymethane-Induced Colorectal Tumorigenesis in
   C57BL/KsJ-db/db Mice
SO GASTROINTESTINAL DISORDERS
LA English
DT Article
DE allopurinol; uric acid; colorectal cancer; chemoprevention; obesity;
   oxidative stress
ID COLONIC PRENEOPLASTIC LESIONS; URIC-ACID; METABOLIC SYNDROME;
   PREMALIGNANT LESIONS; OXIDATIVE STRESS; PROSTATE-CANCER; INFLAMMATION;
   OBESITY; RISK; MECHANISMS
AB Obesity and related metabolic disorders, including chronic inflammation and enhanced oxidative stress, are closely associated with the development and progression of colorectal cancer. Previous epidemiological studies have demonstrated that increased serum uric acid is associated with the risk for various types of cancer, including colon cancer. This study examined the effects of a xanthine oxidase inhibitor allopurinol, widely used as a uric acid lowering medicine, on colorectal tumorigenesis in obese mice. Male C57BL/KsJ-db/db mice were injected with azoxymethane (15 mg/kg body weight) and then received drinking water containing allopurinol (30 mg/kg body weight) for fourteen weeks. At the time of sacrifice, allopurinol treatment significantly inhibited the development of colonic premalignant lesions. In the allopurinol-treated group, cellular proliferation in colonic mucosa was significantly suppressed, which was evaluated by the expression of proliferating cell nuclear antigen. Allopurinol also inhibited macrophage infiltration in the adipose tissue and decreased the serum level of TNF-alpha. The values of oxidative stress markers were markedly decreased in the allopurinol-treated group compared to those in the control group. These findings suggest that allopurinol attenuated chronic inflammation and decreased oxidative stress, preventing the development of colonic pre-neoplastic lesions in obesity-associated colon tumorigenesis model.
C1 [Kato, Junichi; Shirakami, Yohei; Mizutani, Taku; Ideta, Takayasu; Shimizu, Masahito] Gifu Univ, Grad Sch Med, Dept Gastroenterol, Gifu 5011194, Japan.
   [Shirakami, Yohei; Yamaguchi, Kimihiro; Nakamura, Hiroshi; Ninomiya, Soranobu; Kubota, Masaya; Sakai, Hiroyasu; Ibuka, Takashi; Shimizu, Masahito] Gifu Univ Hosp, Dept Internal Med 1, Gifu 5011194, Japan.
   [Tanaka, Takuji] Gifu Municipal Hosp, Dept Pathol Diag, Gifu 5008513, Japan.
C3 Gifu University; Gifu University; Gifu Municipal Hospital
RP Shirakami, Y (corresponding author), Gifu Univ, Grad Sch Med, Dept Gastroenterol, Gifu 5011194, Japan.; Shirakami, Y (corresponding author), Gifu Univ Hosp, Dept Internal Med 1, Gifu 5011194, Japan.
EM yfa52710@nifty.com; ys2443@gifu-u.ac.jp; chris_kimihiro@yahoo.co.jp;
   taku.mizutani0912@gmail.com; taka.mailbox.789@gmail.com;
   ayapokopoko2@gmail.com; soranobu2000@yahoo.co.jp; kubota-gif@umin.ac.jp;
   sakaih03@gifu-u.ac.jp; tibuka-gif@umin.ac.jp; tmntt08@gmail.com;
   shimim-gif@umin.ac.jp
RI Kato, Junichi/S-1469-2018
OI Tanaka, Takuji/0000-0002-1428-1582
FU JSPS KAKENHI [JP17K15936, JP18K07968, JP19K08465]
FX This work was supported by JSPS KAKENHI Grant Numbers JP17K15936,
   JP18K07968, and JP19K08465.
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NR 42
TC 3
Z9 3
U1 0
U2 0
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2624-5647
J9 GASTROINTEST DISORD
JI Gastrointest. Disord.
PD DEC
PY 2020
VL 2
IS 4
BP 385
EP 396
DI 10.3390/gidisord2040035
PG 12
WC Gastroenterology & Hepatology
WE Emerging Sources Citation Index (ESCI)
SC Gastroenterology & Hepatology
GA TE3BP
UT WOS:000669889500008
OA gold
DA 2025-06-11
ER

PT J
AU Sabe, SA
   Feng, J
   Sellke, FW
   Abid, MR
AF Sabe, Sharif A.
   Feng, Jun
   Sellke, Frank W.
   Abid, M. Ruhul
TI Mechanisms and clinical implications of endothelium-dependent vasomotor
   dysfunction in coronary microvasculature
SO AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
LA English
DT Review
DE coronary; endothelium; microcirculation; microvascular; vasomotor
ID NITRIC-OXIDE SYNTHASE; NECROSIS-FACTOR-ALPHA; VASCULAR OXIDATIVE STRESS;
   GLYCATION END-PRODUCTS; LOW-DENSITY-LIPOPROTEIN; FLOW-INDUCED DILATION;
   NO-MEDIATED DILATION; SHEAR-STRESS; INSULIN-RESISTANCE; TNF-ALPHA
AB Coronary microvascular disease (CMD), which affects the arterioles and capillary endothelium that regulate myocardial perfusion, is an increasingly recognized source of morbidity and mortality, particularly in the setting of metabolic syndrome. The coronary endothelium plays a pivotal role in maintaining homeostasis, though factors such as diabetes, hypertension, hyperlipidemia, and obesity can contribute to endothelial injury and consequently arteriolar vasomotor dysfunction. These disturbances in the coronary microvasculature clinically manifest as diminished coronary flow reserve, which is a known independent risk factor for cardiac death, even in the absence of macrovascular atherosclerotic disease. Therefore, a growing body of literature has examined the molecular mechanisms by which coronary microvascular injury occurs at the level of the endothelium and the consequences on arteriolar vasomotor responses. This review will begin with an overview of normal coronary microvascular physiology, modalities of measuring coronary microvascular function, and clinical implications of CMD. These introductory topics will be followed by a discussion of recent advances in the understanding of the mechanisms by which inflammation, oxidative stress, insulin resistance, hyperlipidemia, hypertension, shear stress, endothelial cell senescence, and tissue ischemia dysregulate coronary endothelial homeostasis and arteriolar vasomotor function.
C1 [Sabe, Sharif A.; Feng, Jun; Sellke, Frank W.; Abid, M. Ruhul] Rhode Isl Hosp, Cardiovasc Res Ctr, Providence, RI 02902 USA.
   [Sabe, Sharif A.; Feng, Jun; Sellke, Frank W.; Abid, M. Ruhul] Brown Univ, Alpert Med Sch, Div Cardiothorac Surg, Providence, RI 02912 USA.
   [Sabe, Sharif A.; Feng, Jun; Sellke, Frank W.; Abid, M. Ruhul] Rhode Isl Hosp, Providence, RI 02903 USA.
C3 Lifespan Health Rhode Island; Rhode Island Hospital; Brown University;
   Lifespan Health Rhode Island; Rhode Island Hospital
RP Abid, MR (corresponding author), Rhode Isl Hosp, Cardiovasc Res Ctr, Providence, RI 02902 USA.; Abid, MR (corresponding author), Brown Univ, Alpert Med Sch, Div Cardiothorac Surg, Providence, RI 02912 USA.; Abid, MR (corresponding author), Rhode Isl Hosp, Providence, RI 02903 USA.
EM ruhul_abid@brown.edu
OI sellke, frank/0000-0002-8886-801X; Feng, Jun/0000-0003-4762-7532; Abid,
   Ruhul/0000-0003-2981-2638
FU National Heart, Lung, and Blood Institute [1R01HL133624, R01HL46716,
   R01HL128831-01A1, 1F32HL160063-01]; National Heart Lung and Blood
   Institute [F32HL160063] Funding Source: NIH RePORTER
FX This study was funded by National Heart, Lung, and Blood Institute
   Grants 1R01HL133624 (to M. R. Abid), R01HL46716 and R01HL128831-01A1 (to
   F. W. Sellke), and 1F32HL160063-01 (to S. A. Sabe).
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NR 242
TC 34
Z9 38
U1 2
U2 22
PU AMER PHYSIOLOGICAL SOC
PI Rockville
PA 6120 Executive Blvd, Suite 600, Rockville, MD, UNITED STATES
SN 0363-6135
EI 1522-1539
J9 AM J PHYSIOL-HEART C
JI Am. J. Physiol.-Heart Circul. Physiol.
PD MAY
PY 2022
VL 322
IS 5
BP H819
EP H841
DI 10.1152/ajpheart.00603.2021
PG 23
WC Cardiac & Cardiovascular Systems; Physiology; Peripheral Vascular
   Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Physiology
GA 0W6ZH
UT WOS:000789172700001
PM 35333122
OA Green Published
DA 2025-06-11
ER

PT J
AU Jennelle, LT
   Dandekar, AP
   Magoro, T
   Hahn, YS
AF Jennelle, Lucas T.
   Dandekar, Aditya P.
   Magoro, Tshifhiwa
   Hahn, Young S.
TI Immunometabolic Signaling Pathways Contribute to Macrophage and
   Dendritic Cell Function
SO CRITICAL REVIEWS IN IMMUNOLOGY
LA English
DT Article
DE macrophage; metabolism; ER stress; interferon; cholesterol
ID ENDOPLASMIC-RETICULUM STRESS; LIVER-X-RECEPTOR; HEPATITIS-C VIRUS;
   INFLAMMATORY RESPONSE GENES; TRANSCRIPTION FACTOR XBP1; INNATE
   IMMUNE-RESPONSES; TOLL-LIKE RECEPTORS; HELPER T-CELLS; LIPID-METABOLISM;
   ER STRESS
AB Understanding of antigen-presenting cell (APC) participation in tissue inflammation and metabolism has advanced through numerous studies using systems biology approaches. Previously unrecognized connections between these research areas have been elucidated in the context of inflammatory disease involving innate and adaptive immune responses. A new conceptual framework bridges APC biology, metabolism, and cytokines in the generation of effective T-cell responses. Exploring these connections is paramount to addressing the rising tide of multi-organ system diseases, particularly chronic diseases associated with metabolic syndrome, infection, and cancer. Focused research in these areas will aid the development of strategies to harness and manipulate innate immunology to improve vaccine development, anti-viral, anti-inflammatory, and anti-tumor therapies. This review highlights recent advances in APC "immunometabolism" specifically related to chronic viral and metabolic disease in humans. The goal of this review is to develop an abridged and consolidated outlook on recent thematic updates to APC immunometabolism in the areas of regulation and crosstalk between metabolic and inflammatory signaling and the integrated stress response and how these signals dictate APC function in providing T-cell activation Signal 3.
C1 [Jennelle, Lucas T.; Dandekar, Aditya P.; Magoro, Tshifhiwa; Hahn, Young S.] Univ Virginia, Dept Microbiol, Beirne B Carter Ctr Immunol Res, Charlottesville, VA 22908 USA.
C3 University of Virginia
RP Hahn, YS (corresponding author), Univ Virginia, Dept Microbiol, Beirne B Carter Ctr Immunol Res, Charlottesville, VA 22908 USA.
EM ysh5e@eservices.virginia.edu
RI Dandekar, Aditya/L-9510-2019; Magoro, Tshifhiwa/X-3466-2018
OI Magoro, Tshifhiwa/0000-0002-9295-1027
FU National Institutes of Health [R01DK063222, U19AI083024]
FX This work was supported by National Institutes of Health (Grants
   R01DK063222 and U19AI083024).
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NR 94
TC 4
Z9 4
U1 0
U2 9
PU BEGELL HOUSE INC
PI DANBURY
PA 50 NORTH ST, DANBURY, CT 06810 USA
SN 1040-8401
EI 2162-6472
J9 CRIT REV IMMUNOL
JI Crit. Rev. Immunol.
PY 2016
VL 36
IS 5
BP 379
EP 394
DI 10.1615/CritRevImmunol.2017018803
PG 16
WC Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology
GA EU6EC
UT WOS:000401125800002
PM 28605345
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Srimahachota, S
   Wunsuwan, R
   Siritantikorn, A
   Boonla, C
   Chaiwongkarjohn, S
   Tosukhowong, P
AF Srimahachota, Suphot
   Wunsuwan, Rattiporn
   Siritantikorn, Atchasai
   Boonla, Chanchai
   Chaiwongkarjohn, Suttirak
   Tosukhowong, Piyaratana
TI Effects of lifestyle modification on oxidized LDL, reactive oxygen
   species production and endothelial cell viability in patients with
   coronary artery disease
SO CLINICAL BIOCHEMISTRY
LA English
DT Article
DE Coronary artery disease; Lifestyle modification; Oxidized LDL; Reactive
   oxygen species; Human coronary artery endothelial cell
ID LOW-DENSITY-LIPOPROTEIN; OXIDATIVE STRESS; HEART-DISEASE; RISK-FACTORS;
   EXERCISE INTERVENTION; MODIFICATION PROGRAM; METABOLIC SYNDROME;
   GENE-EXPRESSION; MONOCYTE; MARKERS
AB Objectives: We evaluated the effects of lifestyle modification (LM) on lipid profile, oxidative stress and serum-stimulated human coronary artery endothelial cell (HCAEC) viability in coronary artery disease (CAD) patients after 6 months.
   Design and methods: Thirty patients with CAD were randomly assigned to LM intervention (n=15) and usual care control (n=15) groups. LM-intervened patients were instructed to consume low-fat, high-antioxidants and fiber diets. Moderate exercise and stress management were also advised. Group support to maintain patients' compliance was applied.
   Results: Serum cholesterol, triglyceride, oxidized LDL and protein carbonyl were decreased in LM group. Serum triglyceride was increased in control group. HCAEC viability was increased, while intracellular reactive oxygen species was decreased, by serum from the LM group.
   Conclusion: LM is capable of improving lipid profile, reducing oxidative stress and increasing HCAEC survival in the patients with CAD, hence lowering a risk for the future cardiovascular event. (c) 2010 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
C1 [Wunsuwan, Rattiporn; Boonla, Chanchai; Chaiwongkarjohn, Suttirak; Tosukhowong, Piyaratana] Chulalongkorn Univ, Dept Biochem, Fac Med, Bangkok 10130, Thailand.
   [Srimahachota, Suphot] Chulalongkorn Univ, Dept Med, Fac Med, Bangkok 10130, Thailand.
C3 Chulalongkorn University; Chulalongkorn University
RP Tosukhowong, P (corresponding author), Chulalongkorn Univ, Dept Biochem, Fac Med, Bangkok 10130, Thailand.
EM piyaratana_t@yahoo.com
OI Boonla, Chanchai/0000-0002-6515-4321; Srimahachota,
   Suphot/0000-0002-5181-961X
FU Ratchadapiseksompotch Fund; Chulalongkorn University; 90th Anniversary
   of Chulalongkorn University Fund (Ratchadaphiseksomphot Endowment Fund)
FX The study was supported by grants from the Ratchadapiseksompotch Fund,
   the Chulalongkorn University and the 90th Anniversary of Chulalongkorn
   University Fund (Ratchadaphiseksomphot Endowment Fund).
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NR 32
TC 17
Z9 19
U1 0
U2 4
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0009-9120
EI 1873-2933
J9 CLIN BIOCHEM
JI Clin. Biochem.
PD JUL
PY 2010
VL 43
IS 10-11
BP 858
EP 862
DI 10.1016/j.clinbiochem.2010.04.056
PG 5
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA 615KD
UT WOS:000279133100010
PM 20416290
DA 2025-06-11
ER

PT J
AU Federico, A
   Conti, V
   Russomanno, G
   Dallio, M
   Masarone, M
   Stiuso, P
   Tuccillo, C
   Caraglia, M
   Manzo, V
   Persico, M
   Filippelli, A
   Loguercio, C
AF Federico, Alessandro
   Conti, Valeria
   Russomanno, Giusy
   Dallio, Marcello
   Masarone, Mario
   Stiuso, Paola
   Tuccillo, Concetta
   Caraglia, Michele
   Manzo, Valentina
   Persico, Marcello
   Filippelli, Amelia
   Loguercio, Carmelina
TI A Long-term Treatment with Silybin in Patients with Non-alcoholic
   Steatohepatitis Stimulates Catalase Activity in Human Endothelial Cells
SO IN VIVO
LA English
DT Article
DE Endothelial cells; non-alcoholic steatohepatitis; oxidative stress;
   silybin; thiobarbituric acid reactive substances
ID FATTY LIVER-DISEASE; HEPATIC STELLATE CELLS; METABOLIC SYNDROME;
   OXIDATIVE STRESS; PHOSPHOLIPID COMPLEX; INSULIN-RESISTANCE; FIBROSIS;
   INHIBITION; SEVERITY; CRITERIA
AB Aim: To compare levels of oxidative stress markers in patients' sera with non-alcoholic steatohepatitis (NASH) treated for 12 months (T-12) with silybin conjugated with phosphatidylcholine (Realsil (R)) (R) or placebo (P) and investigate oxidative stress responses in human endothelial cells conditioned with patients' sera. Patients and Methods: We recruited twenty-seven patients with histological NASH. We measured thiobarbituric acid reactive substances (TBARS), superoxide dismutase (SOD) and catalase (CAT) activities in human endothelial cells conditioned with patients' sera exposed or not to H2O2. Results: We found in decreased-TBARS patients' sera, at T-12, a decrease of alanine aminotransferase (p=0.038), transforming growth factor-beta (p=0.009) and procollagen I (p=0.001). By dividing patients into two groups, increased (P-I/R-I) and decreased TBARS (P-II/R-II) at T-12 compared to T-0, we found an increased CAT activity in conditioned endothelial cells at T12 in both groups (p=0.05 and p=0.001, respectively). Conclusion: Realsil (R) may be effective against endothelial dysfunction by stimulating the cellular antioxidant defense.
C1 [Federico, Alessandro; Dallio, Marcello; Tuccillo, Concetta; Loguercio, Carmelina] Univ Campania L Vanvitelli, Dept Clin & Expt Med, Via Pansini 5, I-80125 Naples, Italy.
   [Stiuso, Paola; Caraglia, Michele] Univ Campania L Vanvitelli, Dept Biochem Biophys & Gen Pathol, Naples, Italy.
   [Conti, Valeria; Russomanno, Giusy; Masarone, Mario; Manzo, Valentina; Persico, Marcello; Filippelli, Amelia] Univ Salerno, Dept Med & Surg, Salerno, Italy.
C3 Universita della Campania Vanvitelli; Universita della Campania
   Vanvitelli; University of Salerno
RP Federico, A (corresponding author), Univ Campania L Vanvitelli, Dept Clin & Expt Med, Via Pansini 5, I-80125 Naples, Italy.
EM alessandro.federico@unicampania.it
RI Manzo, Valentina/IQR-9626-2023; persico, marcello/AAB-3562-2019;
   Caraglia, Michele/AFY-9729-2022; Dallio, Marcello/ABG-7693-2020;
   Federico, Alessandro/AAB-3893-2019; Filippelli, Amelia/AAC-5321-2022;
   Russomanno, Giusy/HHN-6777-2022; Masarone, Mario/H-8633-2017; Caraglia,
   Michele/N-5670-2015; Russomanno, Giusy/L-6178-2017
OI Manzo, Valentina/0000-0002-4521-0453; Masarone,
   Mario/0000-0003-0550-8201; Federico, Alessandro/0000-0002-0885-0793;
   Caraglia, Michele/0000-0003-2408-6091; DALLIO,
   MARCELLO/0000-0003-4153-815X; conti, valeria/0000-0001-6964-2739;
   Russomanno, Giusy/0000-0002-3378-5524; Filippelli,
   Amelia/0000-0002-8235-9118; Persico, Marcello/0000-0002-1399-6498
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NR 35
TC 12
Z9 12
U1 0
U2 4
PU INT INST ANTICANCER RESEARCH
PI ATHENS
PA EDITORIAL OFFICE 1ST KM KAPANDRITIOU-KALAMOU RD KAPANDRITI, PO BOX 22,
   ATHENS 19014, GREECE
SN 0258-851X
EI 1791-7549
J9 IN VIVO
JI In Vivo
PD JUL-AUG
PY 2017
VL 31
IS 4
BP 609
EP 618
DI 10.21873/invivo.11101
PG 10
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA EY7AE
UT WOS:000404137100013
PM 28652427
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Magee, N
   Zou, A
   Zhang, YX
AF Magee, Nancy
   Zou, An
   Zhang, Yuxia
TI Pathogenesis of Nonalcoholic Steatohepatitis: Interactions between Liver
   Parenchymal and Nonparenchymal Cells
SO BIOMED RESEARCH INTERNATIONAL
LA English
DT Review
ID HIGH-FAT DIET; HEPATIC STELLATE CELLS; ENDOPLASMIC-RETICULUM STRESS;
   INNATE IMMUNE-RESPONSE; 3 GENE PNPLA3; OXIDATIVE STRESS; KUPFFER CELLS;
   NLRP3 INFLAMMASOME; VITAMIN-E; IN-VIVO
AB Nonalcoholic fatty liver disease (NAFLD) is the most common type of chronic liver disease in the Western countries, affecting up to 25% of the general population and becoming a major health concern in both adults and children. NAFLD encompasses the entire spectrum of fatty liver disease in individuals without significant alcohol consumption, ranging from nonalcoholic fatty liver (NAFL) to nonalcoholic steatohepatitis (NASH) and cirrhosis. NASH is a manifestation of the metabolic syndrome and hepatic disorders with the presence of steatosis, hepatocyte injury (ballooning), inflammation, and, in some patients, progressive fibrosis leading to cirrhosis. The pathogenesis of NASH is a complex process and implicates cell interactions between liver parenchymal and nonparenchymal cells as well as crosstalk between various immune cell populations in liver. Lipotoxicity appears to be the central driver of hepatic cellular injury via oxidative stress and endoplasmic reticulum (ER) stress. This review focuses on the contributions of hepatocytes and nonparenchymal cells to NASH, assessing their potential applications to the development of novel therapeutic agents. Currently, there are limited pharmacological treatments for NASH; therefore, an increased understanding of NASH pathogenesis is pertinent to improve disease interventions in the future.
C1 [Magee, Nancy; Zou, An; Zhang, Yuxia] Univ Kansas, Med Ctr, Dept Pharmacol Toxicol & Therapeut, Kansas City, KS 66160 USA.
C3 University of Kansas; University of Kansas Medical Center
RP Zhang, YX (corresponding author), Univ Kansas, Med Ctr, Dept Pharmacol Toxicol & Therapeut, Kansas City, KS 66160 USA.
EM lzhang5@kumc.edu
RI Zhang, Yuxia/AEO-0635-2022
FU National Institutes of Health [NCI K22CA184146, P20 GM103549,
   T32ES007079]
FX This work is supported by the National Institutes of Health Grants NCI
   K22CA184146, P20 GM103549, and T32ES007079. The authors thank Dr.
   Michele Pritchard and Dr. Andres Rodriguez for the critical reading of
   the manuscript.
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NR 130
TC 84
Z9 90
U1 1
U2 18
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2314-6133
EI 2314-6141
J9 BIOMED RES INT
JI Biomed Res. Int.
PY 2016
VL 2016
AR 5170402
DI 10.1155/2016/5170402
PG 11
WC Biotechnology & Applied Microbiology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Research & Experimental Medicine
GA EA7LN
UT WOS:000386812600001
PM 27822476
OA Green Published, hybrid, Green Submitted
DA 2025-06-11
ER

PT J
AU Hruz, PW
AF Hruz, Paul W.
TI Molecular mechanisms for insulin resistance in treated HIV-infection
SO BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Article
DE insulin sensitivity; glucose transport; in vitro models; HIV protease
   inhibitors; nucleoside reverse transcriptase inhibitors; adipocytokines;
   ER stress; lipotoxicity
ID ENDOPLASMIC-RETICULUM STRESS; PROTEASE INHIBITORS BLOCK;
   SKELETAL-MUSCLE; ADIPOCYTE DIFFERENTIATION; OXIDATIVE STRESS; GLUCOSE
   DISPOSAL; PREADIPOCYTE DIFFERENTIATION; HIV-1-INFECTED PATIENTS;
   MITOCHONDRIAL TOXICITY; ZINC METALLOPROTEINASE
AB Identification and characterization of the molecular mechanisms contributing to the high incidence of insulin resistance in HIV infected patients treated with combined antiretroviral therapy remains a critically important goal in the quest to improve the safety of antiretroviral treatment regimens. The use of in vitro model systems together with the investigation of drug-mediated effects on glucose homeostasis in animals and healthy human volunteers has provided important insight into the contribution of individual drugs to insulin resistance and affected cellular pathways. HIV protease inhibitor mediated blockade of glucose transport and nucleoside reverse transcriptase inhibitor mediated mitochondrial toxicity have been well characterized. Together with growing understanding of mediators of insulin resistance in non-HIV metabolic syndrome, additional cellular effects including the induction of endoplasmic reticulum and oxidative stress, altered adipocytokine secretion, and lipotoxicity have been integrated into this developing picture. Further elucidation of these mechanisms provides potential for the continued development of safer antiviral drugs and targeted treatment of insulin resistance in affected patients. (C) 2010 Elsevier Ltd. All rights reserved.
C1 [Hruz, Paul W.] Washington Univ, Sch Med, Dept Pediat, St Louis, MO 63110 USA.
   [Hruz, Paul W.] Washington Univ, Sch Med, Dept Cell Biol & Physiol, St Louis, MO 63110 USA.
C3 Washington University (WUSTL); Washington University (WUSTL)
RP Hruz, PW (corresponding author), 660 S Euclid Ave,Campus Box 8208, St Louis, MO 63110 USA.
EM hruz_p@kids.wustl.edu
RI Hruz, Paul/LDE-7189-2024
OI Hruz, Paul W/0000-0002-1478-3355
FU Bristol Myers Squibb and Gilead Sciences; NIH [DK064572, HL092798]
FX The author has received grant support from Bristol Myers Squibb and
   Gilead Sciences.This work is supported in part by NIH grants DK064572
   and HL092798.
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NR 84
TC 37
Z9 41
U1 0
U2 6
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1521-690X
EI 1532-1908
J9 BEST PRACT RES CL EN
JI Best Pract. Res. Clin. Endoc. Metab.
PD JUN
PY 2011
VL 25
IS 3
BP 459
EP 468
DI 10.1016/j.beem.2010.10.017
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 831PJ
UT WOS:000295743300006
PM 21663839
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Leisegang, K
   Roychoudhury, S
   Slama, P
   Finelli, R
AF Leisegang, Kristian
   Roychoudhury, Shubhadeep
   Slama, Petr
   Finelli, Renata
TI The Mechanisms and Management of Age-Related Oxidative Stress in Male
   Hypogonadism Associated with Non-communicable Chronic Disease
SO ANTIOXIDANTS
LA English
DT Review
DE antioxidants; noncommunicable chronic disease; nutrition;
   phytonutrients; testosterone; testosterone replacement therapy
ID MITOCHONDRIAL P450 SYSTEMS; HORMONE-BINDING GLOBULIN; LEYDIG-CELLS;
   GENE-EXPRESSION; HYPOGONADOTROPIC HYPOGONADISM; TESTOSTERONE LEVELS;
   BARIATRIC SURGERY; PROTECTIVE ROLE; SEX-HORMONES; WEIGHT-LOSS
AB Androgens have diverse functions in muscle physiology, lean body mass, the regulation of adipose tissue, bone density, neurocognitive regulation, and spermatogenesis, the male reproductive and sexual function. Male hypogonadism, characterized by reduced testosterone, is commonly seen in ageing males, and has a complex relationship as a risk factor and a comorbidity in age-related noncommunicable chronic diseases (NCDs), such as obesity, metabolic syndrome, type 2 diabetes, and malignancy. Oxidative stress, as a significant contributor to the ageing process, is a common feature between ageing and NCDs, and the related comorbidities, including hypertension, dyslipidemia, hyperglycemia, hyperinsulinemia, and chronic inflammation. Oxidative stress may also be a mediator of hypogonadism in males. Consequently, the management of oxidative stress may represent a novel therapeutic approach in this context. Therefore, this narrative review aims to discuss the mechanisms of age-related oxidative stress in male hypogonadism associated with NCDs and discusses current and potential approaches for the clinical management of these patients, which may include conventional hormone replacement therapy, nutrition and lifestyle changes, adherence to the optimal body mass index, and dietary antioxidant supplementation and/or phytomedicines.
C1 [Leisegang, Kristian] Fac Community & Hlth Sci, Sch Nat Med, ZA-7535 Cape Town, South Africa.
   [Roychoudhury, Shubhadeep] Assam Univ, Dept Life Sci & Bioinformat, Silchar 788011, India.
   [Slama, Petr] Mendel Univ Brno, Fac AgriSci, Dept Anim Morphol Physiol & Genet, Brno 61300, Czech Republic.
   [Finelli, Renata] Gamma Anal Clin Srl, I-81100 Caserta, Italy.
C3 Assam University; Mendel University in Brno
RP Leisegang, K (corresponding author), Fac Community & Hlth Sci, Sch Nat Med, ZA-7535 Cape Town, South Africa.; Slama, P (corresponding author), Mendel Univ Brno, Fac AgriSci, Dept Anim Morphol Physiol & Genet, Brno 61300, Czech Republic.
EM kleisegang@uwc.ac.za; shubhadeep1@gmail.com; petr.slama@mendelu.cz;
   finelli.renata@gmail.com
RI Leisegang, Kristian/AAS-3925-2021; Slama, Petr/L-3576-2018;
   Roychoudhury, Shubhadeep/O-8301-2015
OI Slama, Petr/0000-0003-0570-259X; FINELLI, RENATA/0000-0002-5926-6407;
   Roychoudhury, Shubhadeep/0000-0003-4174-1852; Leisegang,
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NR 206
TC 24
Z9 25
U1 1
U2 23
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD NOV
PY 2021
VL 10
IS 11
AR 1834
DI 10.3390/antiox10111834
PG 20
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA XK2EX
UT WOS:000727286000001
PM 34829704
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Casanova, E
   Salvadó, J
   Crescenti, A
   Gibert-Ramos, A
AF Casanova, Ester
   Salvado, Josepa
   Crescenti, Anna
   Gibert-Ramos, Albert
TI Epigallocatechin Gallate Modulates Muscle Homeostasis in Type 2 Diabetes
   and Obesity by Targeting Energetic and Redox Pathways: A Narrative
   Review
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE epigallocatechin gallate; obesity; muscle; oxidative stress; cell
   signaling
ID GREEN TEA POLYPHENOL; HIGH-FAT DIET; ENDOPLASMIC-RETICULUM STRESS;
   BIOACTIVE FOOD INGREDIENTS; INSULIN-RESISTANCE; SKELETAL-MUSCLE;
   OXIDATIVE STRESS; METABOLIC SYNDROME; GLUCOSE-UPTAKE;
   (-)-EPIGALLOCATECHIN GALLATE
AB Obesity is associated with the hypertrophy and hyperplasia of adipose tissue, affecting the healthy secretion profile of pro- and anti-inflammatory adipokines. Increased influx of fatty acids and inflammatory adipokines from adipose tissue can induce muscle oxidative stress and inflammation and negatively regulate myocyte metabolism. Muscle has emerged as an important mediator of homeostatic control through the consumption of energy substrates, as well as governing systemic signaling networks. In muscle, obesity is related to decreased glucose uptake, deregulation of lipid metabolism, and mitochondrial dysfunction. This review focuses on the effect of epigallocatechin-gallate (EGCG) on oxidative stress and inflammation, linked to the metabolic dysfunction of skeletal muscle in obesity and their underlying mechanisms. EGCG works by increasing the expression of antioxidant enzymes, by reversing the increase of reactive oxygen species (ROS) production in skeletal muscle and regulating mitochondria-involved autophagy. Moreover, EGCG increases muscle lipid oxidation and stimulates glucose uptake in insulin-resistant skeletal muscle. EGCG acts by modulating cell signaling including the NF-B, AMP-activated protein kinase (AMPK), and mitogen-activated protein kinase (MAPK) signaling pathways, and through epigenetic mechanisms such as DNA methylation and histone acetylation.
C1 [Casanova, Ester; Salvado, Josepa; Gibert-Ramos, Albert] Univ Rovira & Virgili, Dept Biochem & Biotechnol, Nutrigen Res Grp, Campus Sescelades, E-43007 Tarragona, Spain.
   [Crescenti, Anna] EURECAT Technol Ctr Catalonia, Technol Unit Nutr & Hlth, Avinguda Univ 1, Reus 43204, Spain.
C3 Universitat Rovira i Virgili
RP Casanova, E; Gibert-Ramos, A (corresponding author), Univ Rovira & Virgili, Dept Biochem & Biotechnol, Nutrigen Res Grp, Campus Sescelades, E-43007 Tarragona, Spain.
EM ester.casanova@urv.cat; mariajosepa.salvado@urv.cat;
   anna.crescenti@eurecat.org; albert.gibert@urv.cat
RI Crescenti, Anna/AAA-7557-2019; Gibert Ramos, Albert/F-4438-2017;
   SALVADO, JOSEPA/B-6062-2015
OI Gibert Ramos, Albert/0000-0002-5987-1164; SALVADO,
   JOSEPA/0000-0003-3883-3326; Casanova, Ester/0000-0001-8256-9855;
   Crescenti, Anna/0000-0001-8581-0616
FU Spanish Ministerio de Economia y Competitividad [AGL2013-40707-R,
   AGL2016-77105-R]
FX This research was funded by the Spanish Ministerio de Economia y
   Competitividad (grant numbers AGL2013-40707-R and AGL2016-77105-R).
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NR 127
TC 60
Z9 62
U1 1
U2 34
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD FEB 1
PY 2019
VL 20
IS 3
AR 532
DI 10.3390/ijms20030532
PG 16
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA HQ4WR
UT WOS:000462412500076
PM 30691224
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Bond, LM
   Burhans, MS
   Ntambi, JM
AF Bond, Laura M.
   Burhans, Maggie S.
   Ntambi, James M.
TI Uncoupling protein-1 deficiency promotes brown adipose tissue
   inflammation and ER stress
SO PLOS ONE
LA English
DT Article
ID ENDOPLASMIC-RETICULUM STRESS; GLUCOSE-HOMEOSTASIS; THERMOGENESIS;
   OBESITY; UCP1; MICE; MITOCHONDRIA; MACROPHAGES; ADAPTATION; MODEL
AB Inflammation and endoplasmic reticulum (ER) stress are hallmarks of metabolic syndrome. While these metabolic derangements have been well-investigated in white adipose tissue, their existence and etiology in brown adipose tissue (BAT) are poorly understood. Here, we aimed to investigate ER homeostasis and the inflammatory status and of BAT lacking uncoupling protein-1 (UCP1), a protein required for BAT thermogenesis. H&E staining illustrated lipid accumulation and crown-like structures surrounding adipocytes in BAT of UCP1-/- mice housed at room temperature compared to control mice. Further, immunohistological evaluation of F4/80 and gene expression studies demonstrated BAT macrophage infiltration and robust elevation of pro-inflammatory markers in UCP1-/- BAT. ER stress was also present in BAT of UCP1-/- mice, as evidenced by elevated gene expression and post-translational modifications of unfolded protein response components. After four weeks of thermoneutral housing, UCP1-/- mice did not exhibit elevated BAT inflammation and ER stress gene expression compared to WT mice, but depot expansion persisted. Collectively, we demonstrate that the effects of UCP1 deficiency in BAT are not restricted to mitochondria) uncoupling. We conclude that brown adipose tissue of UCP1-/- mice exhibits proinflammatory immune cell infiltration and perturbations in ER homeostasis and that this phenotype is driven by cold exposure rather than lipid accumulation.
C1 [Bond, Laura M.; Ntambi, James M.] Univ Wisconsin, Dept Biochem, 420 Henry Mall, Madison, WI 53705 USA.
   [Burhans, Maggie S.; Ntambi, James M.] Univ Wisconsin, Dept Nutr Sci, 1415 Linden Dr, Madison, WI 53706 USA.
C3 University of Wisconsin System; University of Wisconsin Madison;
   University of Wisconsin System; University of Wisconsin Madison
RP Ntambi, JM (corresponding author), Univ Wisconsin, Dept Biochem, 420 Henry Mall, Madison, WI 53705 USA.; Ntambi, JM (corresponding author), Univ Wisconsin, Dept Nutr Sci, 1415 Linden Dr, Madison, WI 53706 USA.
EM ntambi@biochem.wisc.edu
OI Bond, Laura/0000-0001-7897-4946
FU National Institutes of Health (NIH) [R01 DK062388]; American Diabetes
   Association (ADA) [7-13-BS-118]; United States Department of Agriculture
   (USDA) [W2005]; National Institutes of Health (NIH) National Research
   Service Award [T32 GM07215]
FX This work was supported by National Institutes of Health (NIH,
   https://www.nih.gov/) Grant R01 DK062388, American Diabetes Association
   (ADA, http://www.diabetes.org/) 7-13-BS-118, and United States
   Department of Agriculture (USDA, https://www.usda.gov/) Hatch W2005 (to
   J.M.N.). L.M.B. was supported by National Institutes of Health (NIH,
   https://www.nih.gov/) National Research Service Award T32 GM07215. The
   funders had no role in study design, data collection and analysis,
   decision to publish, or preparation of the manuscript.
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NR 34
TC 28
Z9 28
U1 0
U2 3
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD NOV 14
PY 2018
VL 13
IS 11
AR e0205726
DI 10.1371/journal.pone.0205726
PG 11
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA HA3GQ
UT WOS:000450138500023
PM 30427862
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Leo, F
   Rossodivita, AN
   Segni, CD
   Raimondo, S
   Canichella, S
   Silvestrini, A
   Miggiano, GAD
   Meucci, E
   Mancini, A
AF Leo, F.
   Rossodivita, A. N.
   Segni, C. D.
   Raimondo, S.
   Canichella, S.
   Silvestrini, A.
   Miggiano, G. A. D.
   Meucci, E.
   Mancini, A.
TI Frailty of Obese Children: Evaluation of Plasma Antioxidant Capacity in
   Pediatric Obesity
SO EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
LA English
DT Article
DE oxidative stress; obesity; childhood; antioxidants; metabolic syndrome;
   insulin resistance
ID OXIDATIVE STRESS; ENDOTHELIAL DYSFUNCTION; INSULIN-RESISTANCE;
   MICROVASCULAR FUNCTION; CHILDHOOD OBESITY; MARKERS
AB Background: Obese children are subject to the same chronic oxidative and inflammatory stress, responsible for the onset of all the complications typical of adult age, such as insulin resistance, type 2 diabetes, dyslipidemia and cardiovascular disease.
   Objectives: Since few studies are reported in prepubertal obese children, we investigated the relationship between oxidative stress, body composition and metabolic pattern in childhood obesity in comparison with adult obese patients. Methods: We enrolled 25 prepubertal children (12 males and 13 females) aged 5-12 years with a mean value of standard deviation of BMI (SDS-BMI) +/- SEM of 1.96 +/- 0.09. We performed oral glucose tolerance test, hormonal and metabolic evaluation, bioimpedentiometry, evaluation of total antioxidant capacity using spectroscopical method using a radical cation, 2,2(I)-azinobis(3-ethylbenzothiazoline-6 sulphonate) (ABTS), as indicator of radical formation, with a latency time (LAG) proportional to antioxidant in the sample.
   Results: LAG values significantly correlate with % fat mass, waist circumference and waist/hip ratio. However mean LAG values were significantly lower than in obese adults.
   Conclusions: We suggest that children are more susceptible to oxidative stress than adults, possibly to incomplete development of antioxidant system. Prognostic and therapeutical implications need to be further investigated.
C1 [Leo, F.; Segni, C. D.; Raimondo, S.; Mancini, A.] Univ Cattolica Sacro Cuore, Div Endocrinol, Dept Med Sci, Rome, Italy.
   [Rossodivita, A. N.] Univ Cattolica Sacro Cuore, Inst Pediat, Rome, Italy.
   [Canichella, S.; Miggiano, G. A. D.] Univ Cattolica Sacro Cuore, Dept Lab Med, Dietet Serv, Rome, Italy.
   [Silvestrini, A.; Miggiano, G. A. D.; Meucci, E.] Univ Cattolica Sacro Cuore, Inst Biochem & Clin Biochem, Rome, Italy.
C3 Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli;
   Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli;
   Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli;
   Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli
RP Mancini, A (corresponding author), Largo A Gemelli 8, I-00168 Rome, Italy.; Silvestrini, A (corresponding author), Largo Francesco Vito 1, I-00168 Rome, Italy.
EM asilvestrini@rm.unicatt.it; mancini.giac@mclink.it
RI Silvestrini, Andrea/B-3410-2009
OI Silvestrini, Andrea/0000-0002-2005-3746
CR Atabek ME, 2004, J PEDIATR ENDOCR MET, V17, P1063
   Bernasconi S, 2005, OBESITA ETA EVOLUTIV
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NR 26
TC 16
Z9 16
U1 0
U2 5
PU JOHANN AMBROSIUS BARTH VERLAG MEDIZINVERLAGE HEIDELBERG GMBH
PI STUTTGART
PA RUEDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0947-7349
EI 1439-3646
J9 EXP CLIN ENDOCR DIAB
JI Exp. Clin. Endocrinol. Diabet.
PD SEP
PY 2016
VL 124
IS 8
BP 481
EP 486
DI 10.1055/s-0042-105280
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA DZ2XD
UT WOS:000385704900005
PM 27169687
DA 2025-06-11
ER

PT J
AU Zhang, DX
   Han, W
   Yang, Y
   Tong, X
   Xiao, J
AF Zhang, Dongxing
   Han, Wei
   Yang, Yang
   Tong, Xin
   Xiao, Jing
TI Association Between Dietary Selenium Intake and Kidney Stones Disease
   Among Patients with Metabolic Syndrome: A Cross-Sectional Study from the
   NHANES Database
SO JOURNAL OF MULTIDISCIPLINARY HEALTHCARE
LA English
DT Article
DE dietary selenium; metabolic syndrome; kidney stone diseases; NHANES
   database
ID OBESITY; NEPHROLITHIASIS; CALCIUM; SELENOPROTEINS; HYPERTENSION;
   PREVALENCE; COMPONENTS; NUTRIENTS; ADULTS; SERUM
AB Background: Clinically, metabolic syndrome (MetS) is associated with the formation and relapse of kidney stones diseases (KSD). In the general population, dietary selenium can reduce renal damage by reducing oxidative stress and other physiological pathways. Less is known, however, about the association between dietary selenium and KSD in patients with MetS. Objective: The present study's purpose is to evaluate the association between dietary selenium intake and the odds of KSD in MetS populations. Methods: Data of MetS patients aged >= 20 years were extracted from the National Health and Nutrition Examination Survey (NHANES) database (2007-2018). The information of dietary selenium intake was obtained by 24-hour dietary recall interview. Weighted univariable and multivariate logistic regression analyses were used to evaluate the association of selenium intake with KSD in MetS patients and described as odds ratios (ORs) and 95% confidence intervals (CIs). Subgroup analysis was performed to further discuss this association based on age, gender, and MetS component. Results: In total, 6,073 patients were included, with 766 (12.61%) KSD cases. After adjusting for covariates, high dietary selenium intake was related to lower odds of KSD in MetS patients (OR = 0.70, 95% CI = 0.50-0.97), especially in females (OR = 0.61, 95% CI = 0.39-0.96), those aged <65 years (OR = 0.53, 95% CI = 0.35-0.80), without a history of hypertriglyceridemia (OR = 0.61, 95% CI = 0.40-0.93) and with a history of hypertension (OR = 0.57, 95% CI = 0.38-0.84), diabetes (OR = 0.68, 95% CI = 0.46-0.99) or central obesity (OR = 0.67, 95% CI = 0.48-0.95). Conclusion: From this cross-sectional study, we observed that, among patients with MetS, high dietary selenium intake is associated with lower odds of KSD, implying a potential nutritional strategy for preventing KSD in this population.
C1 [Zhang, Dongxing; Han, Wei; Yang, Yang; Tong, Xin; Xiao, Jing] Capital Med Univ, Beijing Friendship Hosp, Dept Urol, 101,Luyuan East Rd, Beijing 101199, Peoples R China.
   [Han, Wei; Yang, Yang; Tong, Xin; Xiao, Jing] Beijing Municipal Hlth Commiss, Inst Urol, Beijing 101199, Peoples R China.
C3 Capital Medical University
RP Zhang, DX (corresponding author), Capital Med Univ, Beijing Friendship Hosp, Dept Urol, 101,Luyuan East Rd, Beijing 101199, Peoples R China.
EM Dongxing_urology@outlook.com
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NR 55
TC 0
Z9 0
U1 2
U2 2
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-2390
J9 J MULTIDISCIP HEALTH
JI J. Multidiscip. Healthc.
PY 2024
VL 17
BP 6255
EP 6264
DI 10.2147/JMDH.S496819
PG 10
WC Health Care Sciences & Services
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Health Care Sciences & Services
GA R1A2J
UT WOS:001388859900001
PM 39759084
OA gold
DA 2025-06-11
ER

PT J
AU Pirmardan, ER
   Barakat, A
   Zhang, YN
   Naseri, M
   Hafezi-Moghadam, A
AF Ranaei Pirmardan, Ehsan
   Barakat, Aliaa
   Zhang, Yuanlin
   Naseri, Marzieh
   Hafezi-Moghadam, Ali
TI Diabetic cataract in the Nile grass rat: A longitudinal phenotypic study
   of pathology formation
SO FASEB JOURNAL
LA English
DT Article
DE animal model; anterior; posterior subcapsular cataract (ASC; PSC); lens
   epithelial cells (LEC); metabolic syndrome (MetS); type 2 diabetes (T2D)
ID ANTERIOR SUBCAPSULAR CATARACT; METABOLIC SYNDROME; ALDOSE REDUCTASE;
   N-CADHERIN; MODEL; MOUSE; COMPLICATIONS; RETINOPATHY; MECHANISMS;
   OPACITIES
AB Diabetes is a major risk factor for cataract, the leading cause of blindness worldwide. There is an unmet need for a realistic model of diabetic cataract for mechanistic and longitudinal studies, as existing models do not reflect key aspects of the complex human disease. Here, we introduce and characterize diabetic cataract in the Nile grass rat (NGR, Arvicanthis niloticus), an established model of metabolic syndrome and type 2 diabetes (T2D). We conducted a longitudinal study of cataract in over 88 NGRs in their non-diabetic, pre-diabetic, and diabetic stages of metabolism. Oral glucose tolerance test (OGTT) results distinguished the metabolic stages. Diverse cataract types were observed in the course of diabetes, including cortical, posterior subcapsular (PSC), and anterior subcapsular (ASC), all of which succeeded a characteristic dotted ring stage in all animals. The onset ages of diabetes and cataract were 44 +/- 3 vs 29 +/- 1 (P < .001) and 66 +/- 5 vs 58 +/- 6 (not significant) weeks in females and males, respectively. Histological analysis revealed fiber disorganization, vacuolar structures, and cellular proliferation and migration in cataractous lenses. The lens epithelial cells (LECs) in non-diabetic young NGRs expressed the stress marker GRP78, as did LECs and migrated cells in the lenses of diabetic animals. Elucidating mechanisms underlying LEC proliferation and migration will be clinically valuable in prevention and treatment of posterior capsule opacification, a dreaded complication of cataract surgery. Marked changes in N-cadherin expression emphasized a role for LEC integrity in cataractogenesis. Apoptotic cells were dispersed in the equatorial areas in early cataractogenesis. Our study reveals diverse cataract types that spontaneously develop in the diabetic NGR, and which uniquely mirror the cataract and its chronic course of development in individuals with diabetes. We provide mechanistic insights into early stages of diabetic cataract. These unique characteristics make NGR highly suited for mechanistic studies, especially in the context of metabolism, diabetes, and aging.
C1 [Ranaei Pirmardan, Ehsan; Barakat, Aliaa; Zhang, Yuanlin; Hafezi-Moghadam, Ali] Harvard Med Sch, Brigham & Womens Hosp, Dept Radiol, Mol Biomarkers Nanoimaging Lab, 75 Francis St,Thorn Res Bldg, Boston, MA 02115 USA.
   [Naseri, Marzieh] Iran Univ Med Sci, Oncopathol Res Ctr, Tehran, Iran.
   [Naseri, Marzieh] Iran Univ Med Sci, Fac Adv Technol Med, Dept Mol Med, Tehran, Iran.
C3 Harvard University; Harvard University Medical Affiliates; Brigham &
   Women's Hospital; Harvard Medical School; Iran University of Medical
   Sciences; Iran University of Medical Sciences
RP Hafezi-Moghadam, A (corresponding author), Harvard Med Sch, Brigham & Womens Hosp, Dept Radiol, Mol Biomarkers Nanoimaging Lab, 75 Francis St,Thorn Res Bldg, Boston, MA 02115 USA.
EM ahm@bwh.harvard.edu
RI Pirmardan, Ehsan/AAG-3914-2021; Zhang, Yuanlin/MCB-2883-2025
OI Hafezi-Moghadam, Ali/0000-0002-5336-0697; Ranaei Pirmardan,
   Ehsan/0000-0002-6848-5839; Zhang, Yuanlin/0000-0002-3139-3754
FU NIH Impact Award [DK108238-01]; JDRF Innovation award; Malaysian Palm
   Oil Board (MPOB)
FX NIH Impact Award, Grant/Award Number: DK108238-01; JDRF Innovation
   award; Malaysian Palm Oil Board (MPOB)
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NR 51
TC 10
Z9 11
U1 0
U2 13
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0892-6638
EI 1530-6860
J9 FASEB J
JI Faseb J.
PD JUN
PY 2021
VL 35
IS 6
AR e21593
DI 10.1096/fj.202100353R
PG 13
WC Biochemistry & Molecular Biology; Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA SJ7FH
UT WOS:000655695900040
PM 33991133
DA 2025-06-11
ER

PT J
AU Sciarretta, S
   Ferrucci, A
   Ciavarella, GM
   De Paolis, P
   Venturelli, V
   Tocci, G
   De Biase, L
   Rubattu, S
   Volpe, M
AF Sciarretta, Sebastiano
   Ferrucci, Andrea
   Ciavarella, Giuseppino Massimo
   De Paolis, Paola
   Venturelli, Vanessa
   Tocci, Giuliano
   De Biase, Luciano
   Rubattu, Speranza
   Volpe, Massimo
TI Markers of inflammation and fibrosis are related to cardiovascular
   damage in hypertensive patients with metabolic syndrome
SO AMERICAN JOURNAL OF HYPERTENSION
LA English
DT Article
DE inflammation; essential hypertension; metabolic syndrome; cardiovascular
   damage
ID NECROSIS-FACTOR-ALPHA; MONOCYTE CHEMOATTRACTANT PROTEIN-1;
   LEFT-VENTRICULAR MASS; MACROPHAGE INFILTRATION; MYOCARDIAL FIBROSIS;
   OXIDATIVE STRESS; ORGAN DAMAGE; EXPRESSION; DYSFUNCTION; PRESSURE
AB Background: Previous studies have shown that metabolic syndrome (MS) is associated with an increased susceptibility to develop cardiovascular damage (CD). Experimental evidence indicates that inflammation and fibrosis could play a critical role in the development of CD in hypertension. This issue has not been clarified yet in patients with MS. The aim of our study was to investigate the relationship between markers of inflammation and fibrosis with CD in hypertensive patients with and without MS.
   Methods: One hundred twenty-eight essential hypertensive patients were included in the study: 51 with MS and 77 without MS. Clinical, biochemical parameters, 24-h urinary albumin excretion rate (UAER), levels of C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-alpha), transforming growth factor-beta (TGF-beta), and procolla-alpha Oren type I carboxy-terminal propeptide (PICP) were measured. All patients underwent an echocardiographic examination with transmitral Doppler and tissue Doppler imaging (TDI).
   Results: Left ventricular mass indexed by height(2.7) (LVM/h(2.7)) (p < .001), early diastolic peak flow velocity/early myocardial diastolic velocity ratio (E/Em ratio), a TDI index of diastolic function (P < .001), and 24-h UAER (P < .05) were significantly higher in the group with MS, whereas peak myocardial systolic velocity (Sm), a TDI index of systolic function (P < .001), was lower. Serum levels of CRP (P < .001), TNF-alpha (P < .05), TGF-beta (P < .01), and PICP (P < .001) were significantly increased in MS. These markers were significantly related to higher LVMI2.7, higher E/Em ratio, and increased 24-h UAER and a lower Sm in the whole population, with a further significant enhancement in MS.
   Conclusions: Cardiovascular damage is more frequent in hypertensives with MS than in hypertensives without MS, and this is significantly related to the increased levels of inflammation and fibrosis found in hypertensives with MS. Am J Hypertens 2007;20:784-791 (c) 2007 American Journal of Hypertension, Ltd.
C1 Univ Roma La Sapienza, S Andrea Hosp, Sch Med 2, Dept Cardiol, Rome, Italy.
   Polo Molisano Univ Rome La Sapienza, IRCCS Neuromed, Pozzilli, Italy.
   S Pietro Hosp, Res Ctr, AFaR, Rome, Italy.
C3 Sapienza University Rome; Azienda Ospedaliera Sant'Andrea; IRCCS
   Neuromed
RP Ferrucci, A (corresponding author), Univ Roma La Sapienza, Sch Med 2, Dept Cardiol, Via Grottarossa 1039, Rome, Italy.
EM andrea.ferrucci@uniromal.it
RI Volpe, Massimo/K-5240-2016; Rubattu, S./K-4036-2016; Sciarretta,
   Sebastiano/K-5161-2016; Tocci, Giuliano/K-4901-2018; De Biase,
   Luciano/M-6697-2013
OI RUBATTU, Speranza Donatella/0000-0001-5921-7368; Ferrucci,
   Andrea/0000-0002-5923-9310; Sciarretta, Sebastiano/0000-0002-8633-6896;
   Tocci, Giuliano/0000-0002-0635-4921; Rubattu,
   Speranza/0000-0002-9808-7970; De Biase, Luciano/0000-0001-7739-3197;
   Volpe, Massimo/0000-0002-9642-8380
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NR 33
TC 87
Z9 93
U1 0
U2 6
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0895-7061
EI 1941-7225
J9 AM J HYPERTENS
JI Am. J. Hypertens.
PD JUL
PY 2007
VL 20
IS 7
BP 784
EP 791
DI 10.1016/j.amjhyper.2007.01.023
PG 8
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 189HL
UT WOS:000247979900012
PM 17586414
DA 2025-06-11
ER

PT J
AU You, BY
   Cheng, J
   Dun, YS
   Ripley-Gonzalez, JW
   Liu, J
   Li, DZ
   Fu, SQ
   Hong, CX
   Liu, SX
AF You, Baiyang
   Cheng, Jing
   Dun, Yaoshan
   Ripley-Gonzalez, Jeffrey W.
   Liu, Jie
   Li, Dezhao
   Fu, Siqian
   Hong, Chuangxiong
   Liu, Suixin
TI Rhodiola pre-conditioning reduces exhaustive exercise-induced
   myocardial injury of insulin resistant mice
SO SCIENTIFIC REPORTS
LA English
DT Article
ID REDOX STATE; MITOCHONDRIAL; DYSFUNCTION; INFARCTION; MORTALITY;
   CAPACITY; FISSION; STRESS
AB Myocardial injury reduction and recovery under acute cardiac stress are adversely impacted by insulin resistance (IR). We previously demonstrated that Rhodiola improved cardiac anti-stress capacity in mice. Thus, this study focuses on the preventive efficacy of Rhodiola on exhaustive exercise (EE)-induced myocardial injury of IR mice. An 8-week high-fat diet (HFD) model of IR mice was established. Rhodiola was administrated by garaging. After the 8-week intervention, half of the mice performed EE to simulate acute cardiac stress, and determine myocardial injury; The remaining mice were sacrificed following fasting to assess metabolic disorder. We found myocardial injury induced by EE in IR mice was worse and was alleviated by Rhodiola pre-conditioning. Further, the nuclear factor erythroid 2-related factor 2 (Nrf2)-related antioxidant system was impaired by HFD, while mitochondrial dynamic fusion and fission were activated by HFD as a physiological protective compensation. The Rhodiola administration rescued Nrf2 impairment and further facilitated mitochondrial fusion and fission. All these results indicate that Rhodiola is a potential treatment for the prevention of cardiac events in type 2 diabetes mellitus and metabolic syndrome patients, and the Nrf2-related antioxidant activity and mitochondrial dynamics are the proposed mechanisms.
C1 [Cheng, Jing; Hong, Chuangxiong] Guangzhou Univ Chinese Med, Clin Med Coll 1, Guangzhou, Peoples R China.
   [You, Baiyang; Dun, Yaoshan; Ripley-Gonzalez, Jeffrey W.; Li, Dezhao; Fu, Siqian; Liu, Suixin] Cent South Univ, Div Cardiac Rehabil, Dept Phys Med & Rehabil, Xiangya Hosp, Changsha, Hunan, Peoples R China.
   [Cheng, Jing] Shenzhen Dist Yantian Peoples Hosp, Dept Cardiovasc, Shenzhen, Peoples R China.
   [You, Baiyang; Dun, Yaoshan; Fu, Siqian; Liu, Suixin] Cent South Univ, Natl Clin Res Ctr Geriatr Disorders, Xiangya Hosp, Changsha, Hunan, Peoples R China.
   [Dun, Yaoshan] Mayo Clin, Div Prevent Cardiol, Dept Cardiovasc Med, Rochester, MN USA.
   [Liu, Jie] Hunan Tradit Chinese Med Coll, Sch Med, Dept Internal Med, Zhuzhou, Hunan, Peoples R China.
C3 Guangzhou University of Chinese Medicine; Central South University;
   Central South University; Mayo Clinic; Hunan University of Chinese
   Medicine
RP Hong, CX (corresponding author), Guangzhou Univ Chinese Med, Clin Med Coll 1, Guangzhou, Peoples R China.; Liu, SX (corresponding author), Cent South Univ, Div Cardiac Rehabil, Dept Phys Med & Rehabil, Xiangya Hosp, Changsha, Hunan, Peoples R China.; Liu, SX (corresponding author), Cent South Univ, Natl Clin Res Ctr Geriatr Disorders, Xiangya Hosp, Changsha, Hunan, Peoples R China.
EM gz1988hcx@126.com; liusuixin@csu.edu.cn
RI Li, Dezhao/HHZ-2165-2022; Dun, Yaoshan/GOH-2956-2022; Ripley-Gonzalez,
   Jeffrey/JED-5494-2023
OI Dun, Yaoshan/0000-0001-8642-9024
FU National Natural Science Foundation of China [82002403]; Natural Science
   Foundation of Hunan Province [2021JJ60072]
FX This work was supported by grants from the National Natural Science
   Foundation of China (Grant Number: 82002403 to YSD), and Natural Science
   Foundation of Hunan Province (Grant Number: 2021JJ60072 to JL).
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NR 31
TC 3
Z9 3
U1 0
U2 5
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD NOV 23
PY 2022
VL 12
IS 1
AR 20277
DI 10.1038/s41598-022-20376-4
PG 9
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA E0FS0
UT WOS:000972401800002
PM 36434120
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Teixeira, KRC
   dos Santos, CP
   de Medeiros, LA
   Mendes, JA
   Cunha, TM
   De Angelis, K
   Penha-Silva, N
   de Oliveira, EP
   Crispim, CA
AF Teixeira, Kely R. C.
   dos Santos, Camila P.
   de Medeiros, Luciana A.
   Mendes, Jordane A.
   Cunha, Thulio M.
   De Angelis, Katia
   Penha-Silva, Nilson
   de Oliveira, Erick P.
   Crispim, Cibele A.
TI Night workers have lower levels of antioxidant defenses and higher
   levels of oxidative stress damage when compared to day workers
SO SCIENTIFIC REPORTS
LA English
DT Article
ID SOCIAL JETLAG; SHIFT WORK; METABOLIC SYNDROME; SLEEP-DEPRIVATION;
   CIRCADIAN-RHYTHMS; PHYSICAL-ACTIVITY; CHRONOTYPE; MELATONIN; ENZYMES;
   OBESITY
AB The effects of circadian misalignment and work shift on oxidative stress profile of shift workers have not been explored in the literature. The present study aimed to evaluate the role of shift work (day and night) and social jetlag - a measure of circadian misalignment - with oxidative stress markers. A cross-sectional study was performed with 79 men (21-65 years old, 27.56 +/- 4.0 kg/m(2)) who worked the night shift (n = 37) or daytime (n = 42). The analyzed variables included anthropometric measures and determination of systemic levels of markers of oxidative damage and antioxidant defense. Social jetlag was calculated by the absolute difference between the mean sleep point on working and rest days. The night group presented higher systemic values of thiobarbituric acid reactive substances and hydrogen peroxide, and lower levels of nitrite, total antioxidant capacity, and catalase and superoxide dismutase activities in relation to the day group. However, social jetlag was not associated with oxidative stress-related biomarkers analyzed in the night group. These results suggest that the night worker has higher levels of oxidative stress damage and lower levels of antioxidant defenses, while social jetlag was not a possible responsible factor for this condition.
C1 [Teixeira, Kely R. C.; Mendes, Jordane A.; Cunha, Thulio M.; de Oliveira, Erick P.; Crispim, Cibele A.] Univ Fed Uberlandia, Fac Med, Uberlandia, MG, Brazil.
   [dos Santos, Camila P.; De Angelis, Katia] Univ Fed Sao Paulo, Dept Physiol, Sao Paulo, SP, Brazil.
   [de Medeiros, Luciana A.; Penha-Silva, Nilson] Univ Fed Uberlandia, Inst Biotechnol, Uberlandia, MG, Brazil.
C3 Universidade Federal de Uberlandia; Universidade Federal de Sao Paulo
   (UNIFESP); Universidade Federal de Uberlandia
RP Crispim, CA (corresponding author), Univ Fed Uberlandia, Fac Med, Uberlandia, MG, Brazil.
EM cibelecrispim@gmail.com
RI de Medeiros, Luciana/D-2302-2019; de Oliveira, Erick/D-1138-2011; DE
   ANGELIS, KATIA/I-6098-2016; Penha Silva, Nilson/JAC-9711-2023;
   /R-1269-2016
OI P. de Oliveira, Erick/0000-0001-8989-8344; DE ANGELIS,
   KATIA/0000-0002-3640-9049; Penha Silva, Nilson/0000-0002-8205-6213;
   /0000-0002-6638-8197; Cunha, Thulio/0000-0003-2707-757X
FU Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES);
   Conselho Nacional de Pesquisa e Desenvolvimento (CNPq); Fundacao de
   Amparo a Pesquisa do Estado de Minas Gerais (FAPEMIG)
FX To the Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior
   (CAPES) for the doctoral scholarship granted to K.R.C. Teixeira. To the
   Conselho Nacional de Pesquisa e Desenvolvimento (CNPq) for the
   productivity grant awarded to N.P.S. To the Fundacao de Amparo a
   Pesquisa do Estado de Minas Gerais (FAPEMIG) for the funding granted for
   the development of this work. To the volunteers who participated in the
   study. To the Universidade Federal de Uberlandia (UFU), especially to
   the Programa de Pos-Graduacao em Ciencias da Saude (PPGCS), which made
   possible the accomplishment of this research.
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NR 78
TC 64
Z9 68
U1 2
U2 6
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD MAR 14
PY 2019
VL 9
AR 4455
DI 10.1038/s41598-019-40989-6
PG 11
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA HO7TI
UT WOS:000461151800039
PM 30872663
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Décorde, K
   Teissèdre, PL
   Sutra, T
   Ventura, E
   Cristol, JP
   Rouanet, JM
AF Decorde, Kelly
   Teissedre, Pierre-Louis
   Sutra, Thibault
   Ventura, Emilie
   Cristol, Jean-Paul
   Rouanet, Jean-Max
TI Chardonnay grape seed procyanidin extract supplementation prevents
   high-fat diet-induced obesity in hamsters by improving adipokine
   imbalance and oxidative stress markers
SO MOLECULAR NUTRITION & FOOD RESEARCH
LA English
DT Article
DE Antioxidant; Grape seed proanthocyanidins; Hamster; Obesity; Oxidative
   stress
ID HOMEOSTASIS MODEL ASSESSMENT; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   ATHEROGENIC DIET; WINE PHENOLICS; GLUCOSE LEVEL; ACCUMULATION; OXIDASE;
   CELLS; MICE
AB Studies reported the effects of polyphenols but not for grape polyphenols towards obesity. We analysed the effects of a polyphenolic grape seed extract (GSE) on obesity and oxidative stress in hamsters receiving a high-fat diet (HFD). Three groups of hamsters received a standard diet (STD), or a HFD plus a daily gavage with water (Control, HFD) Or a solution of GSE (HFD + GSE) for 12 wk. Plasma glucose, triglycerides (TG), insulin. leptin and adiponectin were measured. Oxidative stress was assessed by cardiac production of superoxide anion and NAD(P)H oxidase expression. After 12 wk, HFD increased abdominal fat as compared with standards. GSE avoided this fracture. HFD led to higher plasma glucose, TG, insulin and greater insulin resistance (HOMA-IR) values. GSE prevented in part these effects, reducing insulinemia and leptinemia by 16.5 and 45%, respectively. whereas adiponectin level increased by 61% compared with obese controls. GSE lowered glycemia and HOMA-IR and strongly prevented cardiac production Of Superoxide by 74% and NAD(P)H oxidase expression by 30%. This is the first time that chronic consumption of grape phenolics is shown to reduce obesity development and related metabolic pathways including adipokine secretion and oxidative stress.
C1 [Decorde, Kelly; Sutra, Thibault; Ventura, Emilie; Cristol, Jean-Paul; Rouanet, Jean-Max] Univ Montpellier 2, EA Nutr Humaine Biodisponibil & Atherogenese 4188, F-34095 Montpellier 5, France.
   [Decorde, Kelly; Sutra, Thibault; Ventura, Emilie; Cristol, Jean-Paul; Rouanet, Jean-Max] Univ Montpellier I, Equipe Accueil Nutr Humaine Biodisponibil & Ather, Montpellier, France.
   [Teissedre, Pierre-Louis] Univ Bordeaux 2, Lab Chim Appl, Fac Enol, INRA,UMR ISVV 1219, Talence, France.
C3 Universite de Montpellier; Universite de Montpellier; Universite de
   Bordeaux; INRAE
RP Rouanet, JM (corresponding author), Univ Montpellier 2, EA Nutr Humaine Biodisponibil & Atherogenese 4188, Pl Eugene Bataillon, F-34095 Montpellier 5, France.
EM jm.rouanet@univ-montp2.fr
RI Teissedre, Pierre-Louis/I-6885-2016
OI TEISSEDRE, Pierre-Louis/0000-0002-0115-5456; , Jean-Paul
   Cristol/0000-0001-8563-7278
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NR 49
TC 108
Z9 122
U1 1
U2 35
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1613-4125
EI 1613-4133
J9 MOL NUTR FOOD RES
JI Mol. Nutr. Food Res.
PD MAY
PY 2009
VL 53
IS 5
BP 659
EP 666
DI 10.1002/mnfr.200800165
PG 8
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA 449CO
UT WOS:000266308600017
PM 19035554
DA 2025-06-11
ER

PT J
AU Taneja, SK
   Mandal, R
   Chechi, A
AF Taneja, Satish Kumar
   Mandal, Reshu
   Chechi, Aman
TI Attenuation of Zn-induced hyperleptinemia/leptin resistance in Wistar
   rat after feeding modified poultry egg
SO NUTRITION & METABOLISM
LA English
DT Article
DE Zn; Cu; Mg; Hyperleptinemia; Leptin resistance; Modified poultry egg;
   Conventional egg
ID METABOLIC SYNDROME-X; LEPTIN CONCENTRATIONS; GENE-EXPRESSION; PLASMA
   LEPTIN; BODY-WEIGHT; FOOD-INTAKE; OBESE GENE; OB PROTEIN; COPPER; ZINC
AB Background: The prevalence of obesity is increasing exponentially world over. Leptin resistance/hyperleptinemia is attributed to its cause in majority of the obese humans where mutation in genetic component or ob gene has not been found operative. The generation of oxidative stress was suggested as its cause. In our previous study, we have reported that the inclusion of antioxidant enriched modified poultry egg (ME) in diet reversed the ionic imbalance and ameliorated the oxidative stress caused by excessive Zn in diet. In the present study, the efficacy of ME verses conventional egg (CE) was tested on Zn-induced leptin resistance in rat model to ascertain if the supplementation of antioxidants in the form of egg can reverse Zn-induced leptin resistance to leptin sensitive state.
   Methods: Hyperleptinemia was induced in rats by feeding them Zn-supplemented hyperleptinemic diets-I and II (Zn-HL-Diet) for 2 months. Thereafter, half of them were fed either on CE or ME mixed Zn-HL-diets I and II for another two months. The data was analyzed applying one way Anova and Tukey's HSD post hoc test.
   Results: The results revealed that food intake, gain in body weight, height and number/unit surface area of intestinal microvillus and serum leptin, glucose, insulin and cortisol were higher in CE and Zn-HL-Diet treated groups; serum Zn, Cu, Mg were higher and Cu and Mg in tissues were lower in them than the control group. In ME treated groups, these parameters were lower and were close to the control group. These changes resulted from the restoration of ionic balance of Zn, Cu and Mg in the blood serum and tissues including liver and hair in ME treated rats.
   Conclusion: The data suggest that Zn-induced leptin resistance can be attenuated through restoring the ionic balance of Zn, Cu and Mg through inclusion of antioxidants in diet such as these modified eggs. But further clinical studies are required before they are put to use for human consumption.
C1 [Taneja, Satish Kumar; Mandal, Reshu; Chechi, Aman] Panjab Univ, Dept Zool, Chandigarh 160014, India.
C3 Panjab University
RP Taneja, SK (corresponding author), Panjab Univ, Dept Zool, Chandigarh 160014, India.
EM sktaneja@gmail.com
FU Emeritus Fellowship; University Grant Commission
FX The authors are thankful to Dr. Neelima R. Kumar, Chairperson,
   Department of Zoology, Panjab University, Chandigarh, India for
   providing necessary laboratory facilities and All India Institute of
   Medical Sciences (New Delhi, India) for Transmission Electron
   Microscopy. The Emeritus Fellowship provided to the senior author, Prof.
   S. K. Taneja by University Grant Commission is gratefully acknowledged.
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NR 52
TC 2
Z9 3
U1 0
U2 4
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1743-7075
J9 NUTR METAB
JI Nutr. Metab.
PD SEP 19
PY 2012
VL 9
AR 85
DI 10.1186/1743-7075-9-85
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 049NM
UT WOS:000311989800001
PM 22992416
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Paoli, A
   Cerullo, G
AF Paoli, Antonio
   Cerullo, Giuseppe
TI Investigating the Link between Ketogenic Diet, NAFLD, Mitochondria, and
   Oxidative Stress: A Narrative Review
SO ANTIOXIDANTS
LA English
DT Review
DE ketogenic diet; nonalcoholic fatty liver disease (NAFLD); mitochondria;
   oxidative stress; liver; ketone bodies
ID FATTY LIVER-DISEASE; GROWTH-FACTOR 21; REACTIVE OXYGEN; KETONE-BODIES;
   INSULIN-RESISTANCE; LOW-CARBOHYDRATE; NONALCOHOLIC STEATOHEPATITIS;
   CALORIC RESTRICTION; MEDITERRANEAN DIET; HEPATIC STEATOSIS
AB Together with the global rise in obesity and metabolic syndrome, the prevalence of individuals who suffer from nonalcoholic fatty liver disease (NAFLD) has risen dramatically. NAFLD is currently the most common chronic liver disease and includes a continuum of liver disorders from initial fat accumulation to nonalcoholic steatohepatitis (NASH), considered the more severe forms, which can evolve in, cirrhosis, and hepatocellular carcinoma. Common features of NAFLD includes altered lipid metabolism mainly linked to mitochondrial dysfunction, which, as a vicious cycle, aggravates oxidative stress and promotes inflammation and, as a consequence, the progressive death of hepatocytes and the severe form of NAFLD. A ketogenic diet (KD), i.e., a diet very low in carbohydrates (<30 g/die) that induces "physiological ketosis", has been demonstrated to alleviate oxidative stress and restore mitochondrial function. Based on this, the aim of the present review is to analyze the body of evidence regarding the potential therapeutic role of KD in NAFLD, focusing on the interplay between mitochondria and the liver, the effects of ketosis on oxidative stress pathways, and the impact of KD on liver and mitochondrial function.
C1 [Paoli, Antonio; Cerullo, Giuseppe] Univ Padua, Dept Biomed Sci, I-35131 Padua, Italy.
   [Paoli, Antonio] UCAM Catholic Univ Murcia, Res Ctr High Performance Sport, Murcia 30107, Spain.
C3 University of Padua; Universidad Catolica de Murcia
RP Paoli, A (corresponding author), Univ Padua, Dept Biomed Sci, I-35131 Padua, Italy.; Paoli, A (corresponding author), UCAM Catholic Univ Murcia, Res Ctr High Performance Sport, Murcia 30107, Spain.
EM antonio.paoli@unipd.it; giuseppe.cerullo@unipd.it
RI Cerullo, Giuseppe/LPQ-9161-2024; Paoli, Antonio/A-6151-2015
OI Paoli, Antonio/0000-0003-0474-4229; Cerullo,
   Giuseppe/0000-0001-8098-2283
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NR 183
TC 36
Z9 37
U1 4
U2 60
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD MAY 8
PY 2023
VL 12
IS 5
AR 1065
DI 10.3390/antiox12051065
PG 19
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA H3YW5
UT WOS:000995365700001
PM 37237931
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Qu, BZ
   Liu, XM
   Liang, YJ
   Zheng, KK
   Zhang, CL
   Lu, LL
AF Qu, Baozhen
   Liu, Xuemao
   Liang, Yanjiao
   Zheng, Keke
   Zhang, Chunling
   Lu, Linlin
TI Salidroside in the Treatment of NAFLD/NASH
SO CHEMISTRY & BIODIVERSITY
LA English
DT Review
DE NAFLD; NASH; salidroside; liver; lipid metabolism
ID NONALCOHOLIC FATTY LIVER; ENDOPLASMIC-RETICULUM STRESS; NF-KAPPA-B;
   OXIDATIVE STRESS; TGF-BETA; AMERICAN ASSOCIATION; INSULIN-RESISTANCE;
   TARGET GENES; CELL-DEATH; IN-VITRO
AB Non-alcoholic fatty liver disease (NAFLD) is the commonest reason for chronic liver diseases in the world and is commonly related to the hepatic manifestation of the metabolic syndrome. Non-alcoholic steatohepatitis (NASH) is a deteriorating form of NAFLD, which can eventually develop into fibrosis, cirrhosis, and liver cancer. The reason for NAFLD/NASH development is complicated, such as liver lipid metabolism, oxidative stress, inflammatory response, apoptosis and autophagy, liver fibrosis and gut microbiota. Apart from bariatric surgery and lifestyle changes, officially approved drug therapy for NAFLD/NASH treatment is lacking. Salidroside (SDS) is a phenolic compound extensively distributed in the tubers of Rhodiola plants, which possesses many significant biological activities. This review summarized the related targets regulated by SDS in treating NAFLD/NASH. It is indicated that SDS could improve the status of NAFLD/NASH by ameliorating abnormal lipid metabolism, inhibiting oxidative stress, regulating apoptosis and autophagy, reducing inflammatory response, alleviating fibrosis and regulating gut microbiota. In conclusion, although the multiple bioactivities of SDS have been confirmed, the clinical data are inadequate and need to become the focus of attention in the later study.
C1 [Qu, Baozhen; Liu, Xuemao; Zhang, Chunling; Lu, Linlin] Qingdao Univ, Qingdao Canc Prevent & Treatment Res Inst, Qingdao Cent Hosp, Affiliated Hosp 2,Med Coll, 127 Siliunan Rd, Qingdao 266042, Peoples R China.
   [Liang, Yanjiao; Zheng, Keke] Qingdao Univ, Dept Oncol Ctr, Qingdao Cent Hosp, Affiliated Hosp 2,Med Coll, Qingdao 266042, Shandong, Peoples R China.
C3 Qingdao University; Qingdao University
RP Zhang, CL; Lu, LL (corresponding author), Qingdao Univ, Qingdao Canc Prevent & Treatment Res Inst, Qingdao Cent Hosp, Affiliated Hosp 2,Med Coll, 127 Siliunan Rd, Qingdao 266042, Peoples R China.
EM lulinlin2007@hotmail.com; qdzcl2011@163.com
RI Zheng, Keke/R-3085-2019; zhang, chunxiu/KVX-8013-2024
OI Lu, Linlin/0000-0002-2062-4887
FU National Natural Science Foundation of China [31800660]
FX This work was supported by National Natural Science Foundation of China
   (grant number 31800660).
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NR 164
TC 16
Z9 18
U1 4
U2 57
PU WILEY-V C H VERLAG GMBH
PI WEINHEIM
PA POSTFACH 101161, 69451 WEINHEIM, GERMANY
SN 1612-1872
EI 1612-1880
J9 CHEM BIODIVERS
JI Chem. Biodivers.
PD DEC
PY 2022
VL 19
IS 12
DI 10.1002/cbdv.202200401
EA NOV 2022
PG 16
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 8I6QJ
UT WOS:000883115500001
PM 36210339
DA 2025-06-11
ER

PT J
AU Hasan, M
   Mohieldein, A
AF Hasan, Marghoob
   Mohieldein, Abdelmarouf
TI Association between serum carcinoembryonic antigen level and oxidative
   stress parameters among diabetic females
SO INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
LA English
DT Article
DE Diabetes mellitus; serum carcinoembryonic antigen; oxidative stress;
   cancer marker; malondialdehyde
ID LIPID-PEROXIDATION; BREAST-CANCER; METABOLIC SYNDROME; TYPE-2;
   INFLAMMATION; MALONDIALDEHYDE; PREVALENCE; MELLITUS; IMMUNITY; MARKER
AB In this study we intended to determine serum level of the carcinoembryonic antigen (CEA) and to find out the correlation with oxidative stress parameters among diabetic female in comparison to control subjects. Methods: A total of 120 Saudi (type 2 diabetic "T2DM", n = 60 and healthy non-diabetic, n = 60) nonsmokers females were enrolled in this study. Body mass index (BMI) was estimated using weight and height; CEA, superoxide dismutase (SOD), 8-hydroxy-deoxyguanosine (8-OHDG), malondialdehyde (MDA) were performed using enzyme-linked immunosorbent assay (ELISA) kits. Blood glucose was estimated by GOD/POD method and, glycated haemoglobin (HbA1c) by immunoturbidimetric method. Results: The student's t-test showed significant differences between the diabetics and controls in CEA, blood glucose, age, oxidative stress markers. Moreover, Pearson's correlation coefficient (r) indicated significant correlations between CEA and age, BMI, blood glucose, HbA1, and MDA. No significant correlation was found between CEA and 8-OHdG, SOD. Conclusions: In this study we confirmed that CEA influence with components of type 2 diabetes and glycemic control. We found correlation between Lipid peroxidation and CEA among diabetic female in comparison to control subjects.
C1 [Hasan, Marghoob; Mohieldein, Abdelmarouf] Qassim Univ, Coll Appl Med Sci, Dept Med Labs, Buraydah, Saudi Arabia.
C3 Qassim University
RP Hasan, M (corresponding author), Qassim Univ, Coll Appl Med Sci, Dept Med Labs, POB 6699, Buraydah, Saudi Arabia.
EM mhasanss11@gmail.com
RI Mohieldein, Abdelmarouf/ABE-7360-2021
OI Mohieldein, Abdelmarouf Hassan/0000-0003-2105-3438
CR Aghvami T, 2006, IRAN J PUBLIC HEALTH, V35, P42
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NR 39
TC 16
Z9 16
U1 2
U2 7
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 1940-5901
J9 INT J CLIN EXP MED
JI Int. J. Clin. Exp. Med.
PY 2015
VL 8
IS 4
BP 6489
EP 6494
PG 6
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA CN4CV
UT WOS:000358377700229
PM 26131277
DA 2025-06-11
ER

PT J
AU Nogales, F
   Cebadero, O
   Romero-Herrera, I
   Rua, RM
   Carreras, O
   Ojeda, ML
AF Nogales, Fatima
   Cebadero, Oscar
   Romero-Herrera, Ines
   Rua, Rui Manuel
   Carreras, Olimpia
   Ojeda, Ma Luisa
TI Selenite supplementation modulates the hepatic metabolic sensors AMPK
   and SIRT1 in binge drinking exposed adolescent rats by avoiding
   oxidative stress
SO FOOD & FUNCTION
LA English
DT Article
AB Binge drinking (BD) is the main alcohol consumption pattern among teenagers. Recently, oxidative stress (OS) generated by BD exposure has been related to hepatic metabolic deregulation and cardiovascular dysfunction. This study analyzed if BD by generating oxidative stress modulates the alteration in hepatic energy homeostasis through two important regulators of energy metabolism: the NAD(+)-dependent sirtuin deacetylase (SIRT1) and AMP-activated protein kinase (AMPK) and if supplementation with the antioxidant selenium (Se) improves these metabolic disorders. Four groups of adolescent rats supplemented or not with Se (0.4 ppm) and exposed to intermittent i.p. BD were used. BD rats showed an increased AST/ALT ratio, total bilirubin in serum and lipid peroxidation in the liver. The BD rats also showed a higher abdominal/thoracic ratio and increased levels of TG, gluc, and chol compared to the control group, provoking an increase in mean blood pressure (MBP). This alcohol consumption pattern decreased hepatic Se deposits, cytoplasmic GPx activity, and GSH levels as well as the expressions of two metabolic sensors and the pAMPK/AMPK ratio. Se supplementation restored antioxidant parameters and decreased lipid oxidation, avoiding OS and improving the hepatic expression of pAMPK and SIRT1, contributing to the improvement of metabolic (better lipid profile and IRS-1 expression) and vascular function (lower MBP), and to the increase of hepatic functionality (lower AST/ALT ratio). All these actions decrease cardiometabolic risk factor development in the short and long term and could disrupt the relationship between BD and MS, two problems which are currently affecting adolescents.
C1 [Nogales, Fatima; Cebadero, Oscar; Romero-Herrera, Ines; Carreras, Olimpia; Ojeda, Ma Luisa] Univ Seville, Fac Pharm, Dept Physiol, Seville 41012, Spain.
   [Rua, Rui Manuel] Univ Fernando Pessoa, Fac Hlth Sci, Porto, Portugal.
C3 University of Sevilla; Universidade Fernando Pessoa
RP Carreras, O (corresponding author), Univ Seville, Fac Pharm, Dept Physiol, Seville 41012, Spain.
EM olimpia@us.es
RI Cebadero, Óscar/LGY-2952-2024; Ojeda, Luisa/B-8571-2019; Romero Herrera,
   Inés/JPX-8714-2023; Carreras, olimpia/P-9078-2019; Rua,
   Rui/AGE-0037-2022; Nogales, F/B-8562-2019
OI Cebadero-Dominguez, Oscar/0000-0001-9481-562X; Nogales,
   Fatima/0000-0003-4844-2740; Maria Luisa, Ojeda
   Murillo/0000-0002-9160-2749; ROMERO HERRERA, INES/0000-0001-5394-1849;
   Carreras, Olimpia/0000-0002-3858-0165; Rua, Rui/0000-0002-0227-9573
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NR 60
TC 8
Z9 9
U1 0
U2 15
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PD APR 7
PY 2021
VL 12
IS 7
BP 3022
EP 3032
DI 10.1039/d0fo02831b
PG 11
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA RM3XC
UT WOS:000639596100016
PM 33710180
DA 2025-06-11
ER

PT J
AU Nijsten, K
   Jansen, LAW
   Limpens, J
   Finken, MJJ
   Koot, MH
   Grooten, IJ
   Roseboom, TJ
   Painter, RC
AF Nijsten, Kelly
   Jansen, Larissa A. W.
   Limpens, Jacqueline
   Finken, Martijn J. J.
   Koot, Marjette H.
   Grooten, Iris J.
   Roseboom, Tessa J.
   Painter, Rebecca C.
TI Long-term health outcomes of children born to mothers with hyperemesis
   gravidarum: a systematic review and meta-analysis
SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
LA English
DT Review
DE autism spectrum disorder; cardiometabolic risk factors; dyssomnias;
   hyperemesis gravidarum; long-term effects; meta-analysis;
   neurodevelopmental disorders; systematic review; testicular neoplasms
ID EXPOSED IN-UTERO; PRENATAL EXPOSURE; NEURODEVELOPMENTAL DELAY;
   PERSONALITY-DISORDER; INCREASED RISK; PREGNANCY; WOMEN; FAMINE; NAUSEA;
   CANCER
AB OBJECTIVE: Hyperemesis gravidarum is characterized by severe nausea and vomiting in pregnancy, frequently resulting in severe maternal nutritional deficiency. Maternal undernutrition is associated with adverse offspring health outcomes. Whether hyperemesis gravidarum permanently affects offspring health remains unclear. This review aimed to evaluate the effects of maternal hyperemesis gravidarum on offspring health.
   DATA SOURCES: MEDLINE and Embase were searched from inception to September 6, 2021.
   STUDY ELIGIBILITY CRITERIA: Studies reporting on health at any age beyond the perinatal period of children born to mothers with hyperemesis gravidarum were included.
   METHODS: Two reviewers independently selected studies and extracted data. The Newcastle-Ottawa Quality Assessment Scale was used to assess risk of bias. We conducted a narrative synthesis and meta-analysis where possible. In meta-analyses with high heterogeneity (I-2>75%), we did not provide a pooled odds ratio.
   RESULTS: Nineteen studies were included in this systematic review (n = 1,814,785 offspring). Meta-analysis (n= 619, 2 studies: 1 among adolescents and 1 among adults) showed that hyperemesis gravidarum was associated with anxiety disorder (odds ratio, 1.74; 95% confidence interval, 1.04-2.91; I-2, 0%) and sleep problems in offspring (odds ratio, 2.94; 95% confidence interval, 1.25-6.93; I-2, 0%). Hyperemesis gravidarum was associated with testicular cancer in male offspring aged up to 40 years on meta-analysis (5 studies, n = 20,930 offspring), although heterogeneity was observed on the basis of a wide 95% prediction interval (odds ratio, 1.60; 95% confidence interval, 1.07-2.39; I-2, 0%; 95% prediction interval, 0.83-3.08). All 6 studies reporting on attention deficit (hyperactivity) disorder and autism spectrum disorder reported an increase among children of mothers with hyperemesis gravidarum in comparison with children of unaffected mothers. Meta-analysis showed high heterogeneity, precluding us from reporting a pooled odds ratio. Most studies reporting on cognitive and motor problems found an increase among hyperemesis gravidarum-exposed children. One study investigated brain structure and found smaller cortical volumes and areas among children from hyperemesis gravidarum-affected pregnancies than among those from unaffected pregnancies. Studies evaluating anthropometry and cardiometabolic disease risk of hyperemesis gravidarum-exposed children had inconsistent findings.
   CONCLUSION: Our systematic review showed that maternal hyperemesis gravidarum is associated with small increases in adverse health outcomes among children, including neurodevelopmental disorders, mental health disorders, and possibly testicular cancer, although evidence is based on few studies of low quality.
C1 [Nijsten, Kelly; Jansen, Larissa A. W.; Koot, Marjette H.; Grooten, Iris J.; Roseboom, Tessa J.; Painter, Rebecca C.] Univ Amsterdam, Dept Obstet & Gynecol, Amsterdam Reprod & Dev, Amsterdam UMC, Amsterdam, Netherlands.
   [Nijsten, Kelly; Roseboom, Tessa J.] Univ Amsterdam, Dept Epidemiol & Data Sci, Amsterdam UMC, Amsterdam, Netherlands.
   [Jansen, Larissa A. W.] Amphia Hosp, Dept Obstet & Gynecol, Breda, Netherlands.
   [Limpens, Jacqueline] Univ Amsterdam, Amsterdam UMC, Res Support, Med Lib, Amsterdam, Netherlands.
   [Finken, Martijn J. J.] Vrije Univ Amsterdam, Emma Childrens Hosp, Dept Paediat Endocrinol, Amsterdam UMC, Amsterdam, Netherlands.
C3 University of Amsterdam; University of Amsterdam; Amphia Hospital;
   University of Amsterdam; Emma Children's Hospital; Vrije Universiteit
   Amsterdam; University of Amsterdam
RP Nijsten, K (corresponding author), Univ Amsterdam, Dept Obstet & Gynecol, Amsterdam Reprod & Dev, Amsterdam UMC, Amsterdam, Netherlands.
EM k.nijsten@amsterdamumc.nl
RI Limpens, Jacqueline/AGO-4697-2022; Painter, Rebecca C./W-5933-2019
OI Limpens, Jacqueline/0000-0002-7362-8574; Jansen,
   Larissa/0000-0003-3173-3250; Nijsten, Kelly/0000-0002-5308-5293
FU Amsterdam Reproduction & Development (AR&D) research institute [23346];
   Dutch Heart Foundation [2013T085]
FX This systematic review was funded by the Amsterdam Reproduction &
   Development (AR&D) research institute (grant number 23346) and the Dutch
   Heart Foundation (grant number 2013T085).
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NR 51
TC 33
Z9 35
U1 4
U2 20
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0002-9378
EI 1097-6868
J9 AM J OBSTET GYNECOL
JI Am. J. Obstet. Gynecol.
PD SEP
PY 2022
VL 227
IS 3
BP 414
EP +
DI 10.1016/j.ajog.2022.03.052
EA AUG 2022
PG 33
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA 5D1SL
UT WOS:000864730300005
PM 35367190
DA 2025-06-11
ER

PT J
AU Bastard, JP
   Couffignal, C
   Fellahi, S
   Bard, JM
   Mentre, F
   Salmon, D
   Katlama, C
   Raffi, F
   Leport, C
   Capeau, J
   Chêne, G
   Salamon, R
   Moatti, JP
   Pierret, J
   Spire, B
   Brun-Vézinet, F
   Fleury, H
   Masquelier, B
   Peytavin, G
   Garraffo, R
   Costagliola, D
   Dellamonica, P
   Meyer, L
   Sobel, A
   Cuzin, L
   Dupon, M
   Duval, X
   Le Moing, V
   Marchou, B
   May, T
   Morlat, P
   Rabaud, C
   Waldner-Combernoux, A
   Hardel, L
   Reboud, P
   Couffin-Cadiergues, S
   Marchand, L
   Assuied, A
   Carrieri, P
   Habak, S
   Couturier, F
   Jadand, C
   Perrier, A
   Préau, M
   Protopopescu, C
   Schmit, JL
   Chennebault, JM
   Faller, JP
   Chirouze, C
   Magy-Bertrand, N
   Humbert, P
   Longy-Boursier, M
   Neau, D
   Granier, P
   Ansart, S
   Verdon, R
   Merrien, D
   Chevojon, P
   Levy, Y
   Piroth, L
   Perronne, C
   Froguel, E
   Ceccaldi, J
   Chidiac, C
   Grégoire, V
   Reynes, J
   Fuzibet, JG
   Arsac, P
   Bouvet, E
   Bricaire, F
   Monsonego, J
   Girard, PM
   Herson, S
   Pialoux, G
   Sain, O
   Sellier, P
   Roblot, P
   Bani-Sadr, F
   Michelet, C
   Lucht, F
   Debord, T
   Martin, T
   De Jaureguiberry, JP
   Bernard, L
AF Bastard, J. -P.
   Couffignal, C.
   Fellahi, S.
   Bard, J. -M.
   Mentre, F.
   Salmon, D.
   Katlama, C.
   Raffi, F.
   Leport, C.
   Capeau, J.
   Chene, G.
   Salamon, R.
   Moatti, J. P.
   Pierret, J.
   Spire, B.
   Brun-Vezinet, F.
   Fleury, H.
   Masquelier, B.
   Peytavin, G.
   Garraffo, R.
   Costagliola, D.
   Dellamonica, P.
   Meyer, L.
   Sobel, A.
   Cuzin, L.
   Dupon, M.
   Duval, X.
   Le Moing, V.
   Marchou, B.
   May, T.
   Morlat, P.
   Rabaud, C.
   Waldner-Combernoux, A.
   Hardel, L.
   Reboud, P.
   Couffin-Cadiergues, S.
   Marchand, L.
   Assuied, A.
   Carrieri, P.
   Habak, S.
   Couturier, F.
   Jadand, C.
   Perrier, A.
   Preau, M.
   Protopopescu, C.
   Schmit, J. L.
   Chennebault, J. M.
   Faller, J. P.
   Chirouze, C.
   Magy-Bertrand, N.
   Humbert, P.
   Longy-Boursier, M.
   Neau, D.
   Granier, P.
   Ansart, S.
   Verdon, R.
   Merrien, D.
   Chevojon, P.
   Levy, Y.
   Piroth, L.
   Perronne, C.
   Froguel, E.
   Ceccaldi, J.
   Chidiac, C.
   Gregoire, V.
   Reynes, J.
   Fuzibet, J. G.
   Arsac, P.
   Bouvet, E.
   Bricaire, F.
   Monsonego, J.
   Girard, P. M.
   Herson, S.
   Pialoux, G.
   Sain, O.
   Sellier, P.
   Roblot, P.
   Bani-Sadr, F.
   Michelet, C.
   Lucht, F.
   Debord, T.
   Martin, T.
   De Jaureguiberry, J. P.
   Bernard, L.
CA ANRS CO
   APROCO-COPILOTE Cohort Study
TI Diabetes and dyslipidaemia are associated with oxidative stress
   independently of inflammation in long-term antiretroviral-treated
   HIV-infected patients
SO DIABETES & METABOLISM
LA English
DT Article
DE Diabetes; Dyslipidaemia; HIV-infected patients; Oxidative stress;
   Inflammation
ID C-REACTIVE PROTEIN; HIGH-DENSITY-LIPOPROTEIN; CARDIOVASCULAR-DISEASE;
   IMMUNE ACTIVATION; SUBCLINICAL ATHEROSCLEROSIS; CARDIOMETABOLIC RISK;
   PHOSPHOLIPASE A(2); STATIN THERAPY; OXIDIZED LDL; MARKERS
AB Aim. - Ageing HIV-infected patients controlled by antiretroviral therapy (ART) frequently present age-related comorbidities, such as cardiovascular (CV) events, diabetes, dyslipidaemia, hypertension and chronic kidney disease (CKD). The prevalence of these comorbidities was evaluated in a cohort of long-term-monitored ART-controlled HIV-infected patients, then followed by a search into whether oxidative stress, like inflammation, might be associated with metabolic parameters and/or comorbidities.
   Methods. - Included were 352 long-term ART patients who started with protease inhibitors (Pis) in 1997-1999. They were evaluated at their final visit, 11 years later, for previous CV events, prevalence of diabetes, LDL-related and atherogenic (high TG/HDL) dyslipidaemias, hypertension and CKD. Also measured were circulating biomarkers to explore oxidative stress (Lp-PLA2, oxLDL, oxLDL/LDL ratio, paraoxonase and arylesterase activities), inflammation/immune activation (hsCRP, hslL-6, D dimer, soluble CD14, beta 2 microglobulin, cystatin C), adipokines and insulin resistance. Levels were compared in patients with and without each comorbidity or condition using non-parametric correlation tests and multivariate adjusted analyses.
   Results. - At the final visit, 81.5% of patients were male and were aged (median, IQR) 49 years (45-56); BMI was 23.0 kg/m(2) (21.1-25.4), CD4+ lymphocytes were 620 cells/mm(3) (453-790) and 91.5% had undetectable HIV-1 viral loads. The prevalence of diabetes was 11%, and LDL-related dyslipidaemia 28%, atherogenic dyslipidaemia 9%, hypertension 28%, CKD 9% and previous CV events 9%. Diabetes and atherogenic dyslipidaemia were associated with increased oxidative stress and independently with inflammation. LDL-related dyslipidaemia and impaired fasting glucose were associated with increased oxidative stress. No association of these biomarkers was detected with hypertension, CKD and previous CV events.
   Conclusion. - In long-term-treated HIV-infected patients with frequent comorbid conditions, oxidative stress could be contributing to diabetes and LDL-related and atherogenic dyslipidaemias independently of inflammation. (C) 2019 Elsevier Masson SAS. All rights reserved.
C1 [Bastard, J. -P.; Fellahi, S.; Capeau, J.] Sorbonne Univ, Hop Tenon, AP HP, INSERM,Fac Med,UMR S938,ICAN, 27 Rue Chaligny, F-75571 Paris 12, France.
   [Couffignal, C.; Mentre, F.; Leport, C.] Univ Paris Diderot, COREB APHP, Sorbonne Paris Cite, INSERM,UMR S1137, 16 Rue Henri Huchard, F-75890 Paris 18, France.
   [Bard, J. -M.] CNRS, UFR Sci Pharmaceut & Biol, MMS EA 2160, IUML FR3473, Nantes, France.
   [Bard, J. -M.] Inst Cancerol Ouest, 4 Rue Bras France,BP61112, F-44035 Nantes 1, France.
   [Salmon, D.] Hop Cochin, AP HP, Serv Malad Infect & Trop, 27 Rue Faubourg St Jacques, F-75014 Paris, France.
   [Katlama, C.] UPMC Univ Paris 6, Serv Malad Infect & Trop, Hop Pitie Salpetriere, AP HP,Sorbonne Univ,INSERM,UMR S1136 IPLESP, 47-83 Blvd Hop, F-75013 Paris, France.
   [Raffi, F.] CHU Nantes, Serv Malad Infect & Trop, INSERM, CIC 1413, 1 Pl Alexis Ricordeau, F-44000 Nantes, France.
C3 Assistance Publique Hopitaux Paris (APHP); Sorbonne Universite; Hopital
   Universitaire Tenon - APHP; Institut National de la Sante et de la
   Recherche Medicale (Inserm); Institut National de la Sante et de la
   Recherche Medicale (Inserm); Universite Paris Cite; Centre National de
   la Recherche Scientifique (CNRS); CNRS - Institute for Engineering &
   Systems Sciences (INSIS); Assistance Publique Hopitaux Paris (APHP);
   Universite Paris Cite; Hopital Universitaire Cochin - APHP; Institut
   National de la Sante et de la Recherche Medicale (Inserm); Assistance
   Publique Hopitaux Paris (APHP); Hopital Universitaire Pitie-Salpetriere
   - APHP; Sorbonne Universite; Nantes Universite; CHU de Nantes; Institut
   National de la Sante et de la Recherche Medicale (Inserm)
RP Capeau, J (corresponding author), Fac Med St Antoine Site, 27 Rue Chaligny, F-75571 Paris 12, France.
EM jacqueline.capeau@inserm.fr
RI Salmon, Didier/M-5670-2013; Carrieri, Maria Patrizia/LZG-7375-2025;
   Verdon, Renaud/A-3124-2011; Magy-Bertrand, Nadine/ABE-1285-2021; chene,
   genevieve/H-8665-2014; Mentre, France/AFU-8218-2022; Bard,
   Jean-Marie/AFT-1583-2022; Spire, Bruno/F-5546-2013
OI Spire, Bruno/0000-0002-3546-8020; CHENE, GENEVIEVE/0000-0002-8368-6460;
   Mentre, france/0000-0002-7045-1275; KATLAMA,
   CHRISTINE/0000-0002-5093-4800; Bard, Jean-Marie/0000-0002-9123-8123;
   Couffignal, Camille/0000-0002-5006-6249
FU French Agence Nationale de Recherches sur le Sida et les Hepatites
   Virales (ANRS); Institut National de la Sante et de la Recherche
   Medicale
FX This work was supported by the French Agence Nationale de Recherches sur
   le Sida et les Hepatites Virales (ANRS) and Institut National de la
   Sante et de la Recherche Medicale.
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NR 53
TC 17
Z9 18
U1 1
U2 15
PU MASSON EDITEUR
PI MOULINEAUX CEDEX 9
PA 21 STREET CAMILLE DESMOULINS, ISSY, 92789 MOULINEAUX CEDEX 9, FRANCE
SN 1262-3636
EI 1878-1780
J9 DIABETES METAB
JI Diabetes Metab.
PD DEC
PY 2019
VL 45
IS 6
BP 573
EP 581
DI 10.1016/j.diabet.2019.02.008
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA JX7MB
UT WOS:000503913700010
PM 30862472
OA Green Published
DA 2025-06-11
ER

PT J
AU Ong, P
   Sivanathan, R
   Borgulya, G
   Bizrah, M
   Iqbal, Y
   Andoh, J
   Gaze, D
   Kaski, JC
AF Ong, Peter
   Sivanathan, Ramyya
   Borgulya, Gabor
   Bizrah, Mukhtar
   Iqbal, Yassir
   Andoh, Joycelyn
   Gaze, David
   Kaski, Juan Carlos
TI Obesity, Inflammation and Brachial Artery Flow-Mediated Dilatation:
   Therapeutic Targets in Patients with Microvascular Angina (Cardiac
   Syndrome X)
SO CARDIOVASCULAR DRUGS AND THERAPY
LA English
DT Article
DE Cardiac syndrome X; FMD; hs-CRP; Inflammation; Obesity
ID C-REACTIVE PROTEIN; NORMAL CORONARY ARTERIOGRAMS; ENDOTHELIAL FUNCTION;
   DYSFUNCTION; WOMEN; PATHOPHYSIOLOGY; ATHEROSCLEROSIS; MANAGEMENT;
   ISCHEMIA; PECTORIS
AB The pathophysiology of microvascular angina (cardiac syndrome X, CSX), (effort-induced angina, a positive response to exercise stress testing and angiographically normal coronary arteries) has not been fully elucidated. Various pathogenic mechanisms have been proposed, amongst which coronary microvascular dysfunction features prominently. Management of patients with microvascular angina is often challenging as a substantial number of patients does not respond to conventional anti-anginal therapy. In this study, we sought to assess the association between brachial artery FMD, high-sensitive C-reactive protein (hs-CRP) and cardiovascular risk factors including obesity in patients with cardiac syndrome X.
   Thirty-four consecutive CSX patients (29 female, mean age 60 +/- 9 years) were recruited from a specialised CSX clinic. Twelve asymptomatic subjects (10 female, mean age 51 +/- 12 years) with comparable cardiovascular risk factor profile served as controls. All participants underwent standardized computer-assisted FMD measurements and assessment of hs-CRP concentrations at study entry. Body mass index (BMI), used as a general measure of obesity was calculated as weight (kilograms) divided by height (meters squared). Compared to controls, CSX patients had significantly higher hs-CRP concentrations (p = 0.003) and impaired FMD (p < 0.01). Moreover, among the CSX patients, a correlation between FMD and hs-CRP (r = -0.66, p < 0.01), FMD and BMI (r = 0.377, p = 0.028), and hs-CRP and BMI (r = -0.372, p = 0.030) was found.
   Impaired brachial artery FMD is significantly associated with elevated hs-CRP concentrations and BMI in patients with CSX. The results support the concept that low-grade inflammation and obesity may promote vascular dysfunction in these patients representing therapeutic targets for future research investigations.
C1 [Ong, Peter; Sivanathan, Ramyya; Bizrah, Mukhtar; Iqbal, Yassir; Andoh, Joycelyn; Gaze, David; Kaski, Juan Carlos] St Georges Univ London, Cardiovasc Sci Res Ctr, Div Clin Sci, London SW17 0RE, England.
   [Borgulya, Gabor] St Georges Univ London, Clin Trials Unit, London SW17 0RE, England.
   [Ong, Peter] Robert Bosch Krankenhaus, Dept Cardiol, Stuttgart, Germany.
C3 City St Georges, University of London; St Georges University London;
   City St Georges, University of London; St Georges University London;
   Bosch; Robert Bosch Krankenhaus
RP Kaski, JC (corresponding author), St Georges Univ London, Cardiovasc Sci Res Ctr, Div Clin Sci, London SW17 0RE, England.
EM jkaski@sgul.ac.uk
RI Gaze, David/AAP-6453-2020; Kaski, Juan Carlos/LKM-8031-2024
OI Gaze, David/0000-0002-0544-2356; Borgulya, Gabor/0000-0001-6396-6126
CR Al-Tahami BA, 2011, CLIN HEMORHEOL MICRO, V47, P87, DOI 10.3233/CH-2010-1370
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NR 27
TC 26
Z9 28
U1 0
U2 4
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0920-3206
J9 CARDIOVASC DRUG THER
JI Cardiovasc. Drugs Ther.
PD JUN
PY 2012
VL 26
IS 3
BP 239
EP 244
DI 10.1007/s10557-012-6382-4
PG 6
WC Cardiac & Cardiovascular Systems; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Pharmacology & Pharmacy
GA 955MV
UT WOS:000305024900007
PM 22392186
DA 2025-06-11
ER

PT J
AU Fragasso, G
   Lauretta, L
   Busnardo, E
   Cera, M
   Godino, C
   Colombo, A
   Calori, G
   Todeschini, P
   Spinapolice, E
   Cappelletti, A
   Gianolli, L
   Margonato, A
AF Fragasso, Gabriele
   Lauretta, Ludovica
   Busnardo, Elena
   Cera, Michela
   Godino, Cosmo
   Colombo, Antonio
   Calori, Giliola
   Todeschini, Paola
   Spinapolice, Elena
   Cappelletti, Alberto
   Gianolli, Luigi
   Margonato, Alberto
TI Prognostic role of stress/rest myocardial perfusion scintigraphy in
   patients with cardiac syndrome X
SO INTERNATIONAL JOURNAL OF CARDIOLOGY
LA English
DT Article
DE Cardiac syndrome X; Myocardial perfusion scintigraphy; SPECT; Normal
   coronary arteries; Prognosis
ID CORONARY-ARTERY-DISEASE; TERM-FOLLOW-UP; LEFT-VENTRICULAR FUNCTION;
   SYNDROME EVALUATION WISE; CHEST-PAIN; ANGINA-PECTORIS; ENDOTHELIAL
   DYSFUNCTION; CARDIOVASCULAR EVENTS; HYPERTENSIVE PATIENTS; MICROVASCULAR
   ANGINA
AB Aim: The prognostic utility of myocardial perfusion scintigraphy (MPS) in patients with angiographically normal coronary arteries has not been evaluated yet. Our aim was to determine the prognostic role of positive MPS in patients with angina, positive exercise test and smooth coronary arteries (syndrome X).
   Methods: A total of 156 patients with angina, positive exercise test, positive MPS and normal coronary arteries and 172 patients with angina and positive exercise test who had negative MPS were selected for study. The primary endpoint was combined all-causemortality and hospitalizations for cardiac causes. The secondary endpoint was hospitalization for cardiac causes.
   Results: Kaplan-Meier analysis showed a greater (p = 0.001) incidence of the primary endpoint in patients with positive MPS, compared to those with negative MPS. Additionally, Kaplan-Meier analysis for cardiovascular hospitalization showed a significant difference (p = 0.003) between the two groups. Cox regression analysis, adjusted for age, sex, BMI and antianginal therapy confirmed a significant risk increase for patients with positive MPS, with a hazard ratio (HR) = 3.20 (CI 95%: 1.14-9.02; p = 0.028). Cox analysis for cardiovascular hospitalization also showed a significant risk increase for patients with positive MPS (HR = 3.19; CI 95%: 1.13-9.00; p= 0.03). Finally, Cox analysis showed that patientswith positive MPS tend to have a higher risk to remain symptomatic in the follow-up period (HR = 1.614; CI 95%: 0.999-2.607; p = 0.51).
   Conclusions: This study shows that inducible myocardial hypoperfusion at MPS in patients with syndrome X could discriminate patients with a more severe prognosis, especially in terms of further hospitalization and symptomatic burden. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
C1 [Fragasso, Gabriele; Lauretta, Ludovica; Cera, Michela; Godino, Cosmo; Calori, Giliola; Cappelletti, Alberto; Margonato, Alberto] Ist Sci San Raffaele, Heart Failure Unit, Clin Cardiol, I-20132 Milan, Italy.
   [Busnardo, Elena; Todeschini, Paola; Spinapolice, Elena; Gianolli, Luigi] Ist Sci San Raffaele, Dept Nucl Med, I-20132 Milan, Italy.
   [Colombo, Antonio] Ist Sci San Raffaele, Intervent Cardiol Unit, I-20132 Milan, Italy.
C3 Vita-Salute San Raffaele University; IRCCS Ospedale San Raffaele;
   Vita-Salute San Raffaele University; IRCCS Ospedale San Raffaele;
   Vita-Salute San Raffaele University; IRCCS Ospedale San Raffaele
RP Fragasso, G (corresponding author), Ist Sci San Raffaele, Heart Failure Unit, Via Olgettina 60, I-20132 Milan, Italy.
EM gabriele.fragasso@hsr.it
RI GODINO, COSMO/AAB-5796-2019; gianolli, luigi/AAN-3892-2020; MARGONATO,
   ALBERTO/B-4185-2015; fragasso, gabriele/K-5483-2012; Cappelletti,
   Alberto/AAN-3843-2020; colombo, antonio/N-2960-2015
OI GODINO, COSMO/0000-0003-1319-0010; colombo, antonio/0000-0002-2940-2455
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NR 44
TC 10
Z9 10
U1 0
U2 7
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0167-5273
EI 1874-1754
J9 INT J CARDIOL
JI Int. J. Cardiol.
PD MAY 15
PY 2014
VL 173
IS 3
BP 467
EP 471
DI 10.1016/j.ijcard.2014.03.007
PG 5
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA AG2EC
UT WOS:000335227900038
PM 24679684
DA 2025-06-11
ER

PT J
AU Pan, Q
   Liu, QZ
   Wan, RL
   Kalavagunta, PK
   Liu, L
   Lv, WT
   Qiao, T
   Shang, J
   Wu, HL
AF Pan, Qi
   Liu, Qiongzhen
   Wan, Renling
   Kalavagunta, Praveen Kumar
   Liu, Li
   Lv, Wenting
   Qiao, Tong
   Shang, Jing
   Wu, Huali
TI Selective inhibition of intestinal 5-HT improves neurobehavioral
   abnormalities caused by high-fat diet mice
SO METABOLIC BRAIN DISEASE
LA English
DT Article
DE High-fat diet (HFD); Peripheral 5-HT; Obesity; Behavioral changes;
   Glucose intolerance; Hippocampal 5-HT1A receptors
ID ENTEROCHROMAFFIN CELL HYPERPLASIA; TRYPTOPHAN-HYDROXYLASE INHIBITORS;
   ANXIETY-LIKE BEHAVIOR; SEROTONIN SYNTHESIS; HIPPOCAMPAL MORPHOLOGY;
   SIMVASTATIN TREATMENT; IMMUNOLOGICAL CONTROL; METABOLIC SYNDROME;
   INDUCED OBESITY; BRAIN-INJURY
AB Recent literature reported the adverse effects of high-fat diet (HFD) on animal's emotional and cognitive function. An HFD-induced obesity/hyperlipidemia is accompanied by hormonal and neurochemical changes that can lead to depression. The important roles of gut-derived serotonin (5-Hydroxytryptamine, 5-HT) during this processing have been increasingly focused. Hence, to determine the potential role of gut-derived serotonin, HFD model was established in C57BL/6 mice. At the 4th week of feeding, a pharmacologic inhibitor of gut-derived 5-HT synthesis LP533401 (12.5mg/kg/day), simvastatin (SIM) (5mg/kg/day) and benzafibrate (BZ) (75mg/kg/day) were administered for two weeks by oral gavage. Then, intraperitoneal glucose tolerance test (IPGTT), open field test (OFT), tail suspension test (TST), forced swim test (FST), sucrose preference test (SPT) were used to evaluate metabolic and neurobehavioral performances. Immunohistochemical staining, real-time quantitative PCR and other methods were to explore possible mechanisms. It was found that HFD feeding and drug treatments had some significant effects on neurobehaviors and brain: (1) All administrations reduced the total cholesterol (TC) and triglyceride (TG) parametric abnormality caused by HFD. LP533401 and SIM could significantly improve the impaired glucose tolerance, while BZ had no significant effect. (2) LP533401, SIM and BZ alleviated depression-like behavior of HFD mice in OFT, TST, FST and SPT. (3) LP533401 and SIM reversed the inhibition of Tryptophan Hydroxylase 2, Tph2 gene expression and the activation of Indoleamine 2,3-dioxy-Genase, IDO expression in HFD-treated brain, whereas BZ did not. (4) LP533401, SIM and BZ restored the inhibitory expression of 5-HT1A receptor in HFD hippocampus. Conclusions: Selective inhibition of intestinal 5-HT can attenuate depressive-like behavior, reduce 5-HT1AR impairment in hippocampus and correct abnormal 5-HT pathway in brain while ameliorating HFD-induced glucose intolerance. Further experiments are warranted to define the adequate strategy of targeting peripheral 5-HT for the treatment of such co-morbidity.
C1 [Pan, Qi; Liu, Qiongzhen; Wan, Renling; Kalavagunta, Praveen Kumar; Liu, Li; Lv, Wenting; Shang, Jing; Wu, Huali] China Pharmaceut Univ, State Key Lab Nat Med, Nanjing 210009, Jiangsu, Peoples R China.
   [Pan, Qi; Liu, Qiongzhen; Wan, Renling; Kalavagunta, Praveen Kumar; Liu, Li; Lv, Wenting; Shang, Jing] China Pharmaceut Univ, Jiangsu Key Lab TCM Evaluat & Translat Res, Nanjing 211198, Jiangsu, Peoples R China.
   [Pan, Qi; Wan, Renling; Kalavagunta, Praveen Kumar; Liu, Li; Lv, Wenting; Shang, Jing] China Pharmaceut Univ, Sch Tradit Chinese Pharm, Nanjing 211198, Jiangsu, Peoples R China.
   [Qiao, Tong] Nanjing Drum Tower Hosp, Vasc Surg Dept, Nanjing 210008, Jiangsu, Peoples R China.
   [Shang, Jing] Qinghai Key Lab Tibetan Med Pharmacol & Safety Ev, Xining, Qinghai, Peoples R China.
   [Wu, Huali] China Pharmaceut Univ, Dept Pharmacol, Nanjing 210009, Jiangsu, Peoples R China.
C3 China Pharmaceutical University; China Pharmaceutical University; China
   Pharmaceutical University; Nanjing University; China Pharmaceutical
   University
RP Shang, J; Wu, HL (corresponding author), China Pharmaceut Univ, State Key Lab Nat Med, Nanjing 210009, Jiangsu, Peoples R China.; Shang, J (corresponding author), China Pharmaceut Univ, Jiangsu Key Lab TCM Evaluat & Translat Res, Nanjing 211198, Jiangsu, Peoples R China.; Shang, J (corresponding author), China Pharmaceut Univ, Sch Tradit Chinese Pharm, Nanjing 211198, Jiangsu, Peoples R China.; Shang, J (corresponding author), Qinghai Key Lab Tibetan Med Pharmacol & Safety Ev, Xining, Qinghai, Peoples R China.; Wu, HL (corresponding author), China Pharmaceut Univ, Dept Pharmacol, Nanjing 210009, Jiangsu, Peoples R China.
EM shangjing21cn@163.com; wu5254307@163.com
OI Kalavagunta, Praveen Kumar/0000-0001-8991-8069
FU One Hundred Person Project of The Chinese Academy of Sciences, Applied
   Basic Research Programs of Qinghai Province [Y229461211]; Science and
   Technology Plan Projects in Xinjiang [2014AB043]; 2017 CMA-L'OREAL China
   Skin/Hair Grant [S2017140917]; Prospective Joint Research Project of
   Jiangsu Province [BY2016078-02]; Open Project of State Key Laboratory of
   Natural Medicines [3144060130]; National Natural Science Foundation of
   China [81874331]; Science and Technology Plan Projects in Qinghai
   Province [2015-ZJ-733]
FX This study was supported by One Hundred Person Project of The Chinese
   Academy of Sciences, Applied Basic Research Programs of Qinghai Province
   (Y229461211); Science and Technology Plan Projects in Xinjiang
   (2014AB043); 2017 CMA-L'OREAL China Skin/Hair Grant (No. S2017140917);
   Prospective Joint Research Project of Jiangsu Province (BY2016078-02);
   The Open Project of State Key Laboratory of Natural Medicines (No.
   3144060130); The National Natural Science Foundation of China (No.
   81874331) and Science and Technology Plan Projects in Qinghai Province
   (2015-ZJ-733).
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NR 83
TC 22
Z9 22
U1 0
U2 18
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0885-7490
EI 1573-7365
J9 METAB BRAIN DIS
JI Metab. Brain Dis.
PD JUN
PY 2019
VL 34
IS 3
BP 747
EP 761
DI 10.1007/s11011-019-0392-x
PG 15
WC Endocrinology & Metabolism; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology
GA HY4AX
UT WOS:000468070600006
PM 30931486
DA 2025-06-11
ER

PT J
AU Cao, F
   Yang, M
   Cheng, YQ
   Zhang, XY
   Shi, L
   Li, N
AF Cao, Fang
   Yang, Mei
   Cheng, Yuqi
   Zhang, Xiuyue
   Shi, Li
   Li, Na
TI Correlation analysis of monocyte chemoattractant protein-1 and clinical
   characteristics and cognitive impairment in type 2 diabetes mellitus
   comorbid major depressive disorder
SO FRONTIERS IN AGING NEUROSCIENCE
LA English
DT Article
DE type 2 diabetes mellitus comorbid major depressive disorder; monocyte
   chemoattractant protein-1; clinical characteristics; cognitive
   impairment; pathophysiology
ID INFLAMMATORY MARKERS; METABOLIC SYNDROME; CATHEPSIN-D; SYMPTOMS;
   ASSOCIATION; RISK; METAANALYSIS; SEVERITY; DEMENTIA; PEOPLE
AB IntroductionType 2 diabetes mellitus (T2DM) and major depressive disorder (MDD) are both chronic diseases, and they are often co-morbid. Usually, T2DM and MDD are associated with cognitive impairment, and the comorbidity status of both may increase the risk of cognitive impairment, but the underlying pathogenesis is not clear. Studies have shown that inflammation, especially monocyte chemoattractant protein-1 (MCP-1), could be associated with the pathogenesis of type 2 diabetes mellitus comorbid major depressive disorder. AimsTo investigate the correlations of MCP-1 with clinical characteristics and cognitive impairment in type 2 diabetes mellitus patients combined with major depressive disorder. MethodsA total of 84 participants were recruited in this study, including 24 healthy controls (HC), 21 T2DM patients, 23 MDD patients, and 16 T2DM combined with MDD (TD) patients, to measure the serum MCP-1 levels using Enzyme-linked Immunosorbent Assay (ELISA). And the cognitive function, depression, and anxiety degree were assessed using Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), 17-item Hamilton Depression Scale (HAMD-17), and Hamilton Anxiety Scale (HAMA), respectively. Results(1) Serum MCP-1 expression levels in the TD group were higher than HC, T2DM, and MDD groups, respectively (p < 0.05). And compared with HC and MDD groups, serum MCP-1 levels in the T2DM group were higher (p < 0.05) statistically. Receiver Operating Characteristic (ROC) curve showed that MCP-1 could diagnose T2DM at cut-off values of 503.8 pg./mL (sensitivity 80.95%, specificity 79.17%, AUC = 0.7956) and of 718.1 pg./mL for TD (sensitivity 81.25%, specificity 91.67%, AUC = 0.9271). (2) Group differences in cognitive function were significant. Compared with the HC group, total RBANS scores, attention scores, and language scores in the TD group were lower, respectively (p < 0.05), and total RBANS scores, attention scores, and visuospatial/constructional scores in the MDD group were lower, respectively (p < 0.05). Compared with the T2DM group, immediate memory scores in HC, MDD, and TD groups were lower, respectively, and total RBANS scores in TD were lower (p < 0.05). (3) Correlation analysis showed that hip circumference was negatively correlated with MCP-1 levels in the T2DM group (R = -0.483, p = 0.027), but the correlation disappeared after adjusting age and gender (r = -0.372; p = 0.117), and there were no significant correlations between MCP-1 and other variables. ConclusionMCP-1 may be involved in the pathophysiology of type 2 diabetes mellitus patients combined with major depressive disorder. And MCP-1 may be significant for the early evaluation and diagnosis of TD in the future.
C1 [Cao, Fang; Yang, Mei; Cheng, Yuqi; Li, Na] Kunming Med Univ, Affiliated Hosp 1, Kunming, Yunnan, Peoples R China.
   [Cao, Fang] Third Peoples Hosp Yunnan Prov, Kunming, Yunnan, Peoples R China.
   [Shi, Li] First Peoples Hosp Yuxi, Yuxi, Yunnan, Peoples R China.
   [Zhang, Xiuyue] Kunming Med Univ, Affiliated Hosp 1, Dept Endocrine, Yuxi, Yunnan, Peoples R China.
C3 Kunming Medical University; Kunming Medical University
RP Li, N (corresponding author), Kunming Med Univ, Affiliated Hosp 1, Kunming, Yunnan, Peoples R China.
EM phoebe11@sina.com
RI zhang, xiuyue/LTE-7527-2024; Cheng, Yuqi/HMV-2015-2023
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NR 52
TC 8
Z9 7
U1 1
U2 7
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1663-4365
J9 FRONT AGING NEUROSCI
JI Front. Aging Neurosci.
PD MAY 4
PY 2023
VL 15
AR 1081393
DI 10.3389/fnagi.2023.1081393
PG 11
WC Geriatrics & Gerontology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology; Neurosciences & Neurology
GA G4OI6
UT WOS:000988963800001
PM 37213540
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Mende, A
   Takano, H
   Kodama, Y
   Nakamura, T
   Umetani, K
   Fujioka, D
   Saito, Y
   Kobayashi, T
   Kawabata, K
   Obata, J
   Kitta, Y
   Kugiyama, K
AF Mende, Akira
   Takano, Hajime
   Kodama, Yasushi
   Nakamura, Takamitsu
   Umetani, Ken
   Fujioka, Daisuke
   Saito, Yukio
   Kobayashi, Tsuyoshi
   Kawabata, Ken-ichi
   Obata, Jyun-ei
   Kitta, Yoshinobu
   Kugiyama, Kiyotaka
TI Relation between transcardiac gradient of VEGF and coronary flow
   response in humans
SO INTERNATIONAL JOURNAL OF CARDIOLOGY
LA English
DT Article
DE angiogenesis; growth factors; coronary circulation; acetylcholine;
   endothelial function
ID ENDOTHELIAL GROWTH-FACTOR; CARDIAC SYNDROME-X; NITRIC-OXIDE; FACTOR-I;
   RISK-FACTORS; ANGIOGENESIS; EXPRESSION; ISCHEMIA; LOCALIZATION;
   CIRCULATION
AB Background: Angiogenic growth factors, produced in the myocardium and coronary vascular bed, increase myocardial blood flow. This study examined whether plasma levels of vascular endothelial growth factor (VEGF) in coronary circulation may be related to coronary blood flow responses. Methods: Blood flow responses in the left anterior descending coronary artery to an intracoronary infusion of acetylcholine (ACh) were measured by an intracoronary flow wire technique in 46 consecutive control subjects with normal coronary angiograms and left ventriculograms. Circulating VEGF levels were measured by ELISA in plasma obtained from the aortic root (AO) and anterior interventricular vein (AIV). Results: The transcardiac gradient of VEGF, calculated by the difference in VEGF concentrations between the AIV and AO, showed a positive correlation with the coronary blood flow increase in response to ACh independently of traditional coronary risk factors. In patients with cardiac syndrome X (n = 17), defined as a positive exercise stress test with a normal coronary angiograms and left ventriculogram, the transcardiac VEGF gradient was significantly lower than in the risk factors-matched control subjects (n-21). Conclusions: The transcardiac gradient of plasma VEGF was independently and positively correlated with the coronary blood flow increase in response to ACh. A reduced transcardiac VEGF gradient was present in cardiac syndrome X, a condition with a blunted coronary blood flow response. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
C1 Univ Yamanashi, Grad Sch Med & Engn, Dept Internal Med 2, Yamanashi 4093898, Japan.
C3 University of Yamanashi
RP Kugiyama, K (corresponding author), Univ Yamanashi, Grad Sch Med & Engn, Dept Internal Med 2, 1110 Shimokato,Nakakomagun, Yamanashi 4093898, Japan.
EM kugiyama@yamanashi.ac.jp
RI OBATA, Jun-ei/AAJ-7956-2021; saito, yukio/AAO-5942-2021
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NR 31
TC 3
Z9 3
U1 0
U2 2
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0167-5273
EI 1874-1754
J9 INT J CARDIOL
JI Int. J. Cardiol.
PD JUL 10
PY 2007
VL 119
IS 2
BP 156
EP 162
DI 10.1016/j.ijcard.2006.07.112
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 182ZW
UT WOS:000247543500004
PM 17067705
DA 2025-06-11
ER

PT J
AU Strehli, I
   Burns, RD
   Bai, Y
   Ziegenfuss, DH
   Block, ME
   Brusseau, TA
AF Strehli, Ildiko
   Burns, Ryan D.
   Bai, Yang
   Ziegenfuss, Donna H.
   Block, Martin E.
   Brusseau, Timothy A.
TI Mind-Body Physical Activity Interventions and Stress-Related
   Physiological Markers in Educational Settings: A Systematic Review and
   Meta-Analysis
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Review
DE exercise; meta-analysis; Mind-Body; physical activity; stress; yoga
ID MINDFULNESS-BASED INTERVENTION; CARDIOVASCULAR FITNESS; CARDIOMETABOLIC
   RISK; YOGA INTERVENTION; PERCEIVED STRESS; BLOOD-PRESSURE; HATHA YOGA;
   STUDENTS; CORTISOL; CHILDREN
AB Mind-Body Physical Activity (MBPA) in educational settings is one possible preventive strategy for ameliorating stress-related physiological health parameters. The objectives of this study were to conduct a systematic review of the literature with meta-analyses on the effects of MBPA on stress-related physiological health markers in primary, secondary, and higher education students. In accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, the search for peer-reviewed articles published in English was conducted in PubMed, EBSCOhost, PsychInfo, Scopus, and Cochrane Library databases. Criteria for inclusion consisted of empirical studies targeting the student population (primary, secondary, higher education), studies examining the effectiveness of an MBPA intervention, studies including a control or comparison group (pre-test/post-test studies excluded), studies targeting physiological marker outcomes such as heart rate, blood glucose, cortisol, and blood pressure, and finally, studies examining interventions implemented within educational settings. Twenty-six interventions were eligible for the review and quantitative synthesis, which comprised a total of 1625 participants, with 783 students serving within the control/comparison group. There were statistically significant and large pooled effects for MBPA effectiveness for lowering heart rate (Hedges' g = -1.71, 95% Confidence Interval (CI): -2.43, -0.98), cortisol (Hedges' g = -1.32, 95% CI: -2.50, -0.16), and systolic and diastolic blood pressure (Hedges' g = -1.04, 95% CI: -1.53, -0.58). These effects tended to be stronger in older students compared to younger students. Most analyses were characterized as having high heterogeneity and only 10 of the 26 studies were characterized as good quality (38.4%). MBPA interventions may have a positive impact on specific physiological health markers in students, especially in students within higher education. However, higher-quality research is needed in this area.
C1 [Strehli, Ildiko; Burns, Ryan D.; Bai, Yang; Ziegenfuss, Donna H.; Brusseau, Timothy A.] Univ Utah, Coll Hlth, Dept Hlth & Kinesiol, 250 S 1850 E, Salt Lake City, UT 84112 USA.
   [Block, Martin E.] Univ Virginia, Curry Sch Educ, Dept Kinesiol, Charlottesville, VA 22904 USA.
C3 Utah System of Higher Education; University of Utah; University of
   Virginia
RP Brusseau, TA (corresponding author), Univ Utah, Coll Hlth, Dept Hlth & Kinesiol, 250 S 1850 E, Salt Lake City, UT 84112 USA.
EM Ildiko.Strehli@utah.edu; ryan.d.burns@utah.edu; yang.bai@utah.edu;
   donna.ziegenfuss@utah.edu; meb7u@virginia.edu; tim.brusseau@utah.edu
RI Burns, Ryan/AAL-1393-2020; Bai, Yang/MNO-4555-2025; Ziegenfuss,
   Donna/T-9658-2018
OI Burns, Ryan/0000-0002-5933-4633; Brusseau, Timothy
   A/0000-0002-8234-3546; Bai, Yang/0000-0001-6751-3896; Strehli,
   Ildiko/0000-0003-1127-2186; Ziegenfuss, Donna Harp/0000-0002-9981-5757
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NR 111
TC 13
Z9 16
U1 1
U2 28
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD JAN
PY 2021
VL 18
IS 1
AR 224
DI 10.3390/ijerph18010224
PG 24
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA PP9QO
UT WOS:000606188300001
PM 33396730
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Munguia, L
   Rubio-Gayosso, I
   Ramirez-Sanchez, I
   Ortiz, A
   Hidalgo, I
   Gonzalez, C
   Meaney, E
   Villarreal, F
   Najera, N
   Ceballos, G
AF Munguia, Levy
   Rubio-Gayosso, Ivan
   Ramirez-Sanchez, Israel
   Ortiz, Alicia
   Hidalgo, Isabel
   Gonzalez, Cristian
   Meaney, Eduardo
   Villarreal, Francisco
   Najera, Nayelli
   Ceballos, Guillermo
TI High Flavonoid Cocoa Supplement Ameliorates Plasma Oxidative Stress and
   Inflammation Levels While Improving Mobility and Quality of Life in
   Older Subjects: A Double-Blind Randomized Clinical Trial
SO JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL
   SCIENCES
LA English
DT Article
DE Functional performance; Metabolism; Sarcopenia; Preventative health care
ID SKELETAL-MUSCLE STRENGTH; PHYSICAL-ACTIVITY; (-)-EPICATECHIN;
   RESISTANCE; FRAILTY; HEALTH; ADULTS; PREVALENCE; SARCOPENIA; CAPACITY
AB Background. The age-related decline in mass, strength, and performance of skeletal muscle is associated with loss of independence, falls risk, disability, institutionalization, and death.
   Methods. To determine whether a cocoa supplement enriched in flavonoids can improve plasma markers of oxidative stress and inflammation, physical performance and frailty in middle-aged and older subjects, we conducted a two-phase, randomized, double-blind, clinical trial. The initial study included 60 subjects (55- to 70-year-old) allocated into placebo (P), highly alkalinized (no-flavonoid; NF), or flavonoid-rich natural cocoa (F) beverage groups. The follow-up study included 74 older subjects (65- to 90-year-old) randomly distributed into NF or F groups. Subjects were instructed to consume the beverages once/day for up to 12-weeks. A comprehensive (aging relevant) set of end points were assessed, which included mean change in blood plasma metabolic and oxidative stress indicators, in physical performance tests and quality of life (QoL).
   Results. In the initial study, the F group showed improved glycemia, triglyceridemia, High-density lipoprotein cholesterol, Low-density lipoprotein cholesterol, triglyceridemia/HDL index, and oxidative markers. Performance on the Up and Go test, skeletal muscle index, and quality of life also improved. In the follow-up study, F treatment was associated with significant improvements in metabolic, oxidative stress, and inflammatory endpoints and positive effects on physical performance, frailty indicators, and quality of life (F vs. NF group).
   Conclusions. Regular flavonoids consumption positively affects blood oxidative stress and inflammation end points, cardiometabolic risk markers, physical performance, and quality of life. The sum of such effects may help to mitigate the extent of frailty development in the elderly people.
C1 [Munguia, Levy; Rubio-Gayosso, Ivan; Ramirez-Sanchez, Israel; Hidalgo, Isabel; Gonzalez, Cristian; Meaney, Eduardo; Najera, Nayelli; Ceballos, Guillermo] Escuela Super Med, Sect Estudios Posgrad & Invest, Mexico City, DF, Mexico.
   [Ortiz, Alicia] Inst Politecn Nacl, Escuela Nacl Ciencias Biol, Dept Ingn Bioquim, Mexico City, DF, Mexico.
   [Villarreal, Francisco] Univ Calif San Diego, Sch Med, Dept Med, La Jolla, CA 92093 USA.
   [Villarreal, Francisco] VA San Diego Healthcare Syst, San Diego, CA USA.
C3 Instituto Politecnico Nacional - Mexico; University of California
   System; University of California San Diego; US Department of Veterans
   Affairs; Veterans Health Administration (VHA); VA San Diego Healthcare
   System
RP Ceballos, G (corresponding author), Escuela Super Med, Sect Estudios Posgrad & Invest, Mexico City, DF, Mexico.; Ceballos, G (corresponding author), Inst Politecn Nacl, Lab Invest Integral Cardiometabol, Secc Estudios Posgrad & Invest, Escuela Super Med, Plan San Luis & Diaz Miron, Ciudad De Mexico 11340, Mexico.
EM gceballosr@ipn.mx
RI Ceballos, Guillermo/A-7507-2013; Gonzalez, Cristian/KFQ-2879-2024;
   Rubio-Gayosso, Ivan/L-9455-2017; Najera, Nayelli/P-3146-2016
OI Gonzalez-Ruiz, Cristian/0000-0003-0140-291X; Najera,
   Nayelli/0000-0002-6869-8762; Hidalgo, Emma Isabel/0000-0003-0276-9414;
   Rubio-Gayosso, Ivan/0000-0001-8315-8572; Ceballos,
   Guillermo/0000-0003-2155-3934; Munguia, Levy/0000-0002-7785-6099
FU National Institute of Health [NIH DK98717, AG47326, AG52593]; Consejo
   Nacional de Ciencia y Tecnologia [253769]
FX This work was supported by the National Institute of Health, (NIH
   DK98717, AG47326, AG52593) to Dr. Villarreal and Consejo Nacional de
   Ciencia y Tecnologia (253769) to Dr. Ceballos.
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NR 34
TC 49
Z9 51
U1 2
U2 19
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1079-5006
EI 1758-535X
J9 J GERONTOL A-BIOL
JI J. Gerontol. Ser. A-Biol. Sci. Med. Sci.
PD OCT
PY 2019
VL 74
IS 10
BP 1620
EP 1627
DI 10.1093/gerona/glz107
PG 8
WC Geriatrics & Gerontology; Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA JH9VR
UT WOS:000493117500013
PM 31056655
OA Green Published
DA 2025-06-11
ER

PT J
AU Carter, RN
   Paterson, JM
   Tworowska, U
   Stenvers, DJ
   Mullins, JJ
   Seckl, JR
   Holmes, MC
AF Carter, R. N.
   Paterson, J. M.
   Tworowska, U.
   Stenvers, D. J.
   Mullins, J. J.
   Seckl, J. R.
   Holmes, M. C.
TI Hypothalamic-Pituitary-Adrenal Axis Abnormalities in Response to
   Deletion of 11β-HSD1 is Strain-Dependent
SO JOURNAL OF NEUROENDOCRINOLOGY
LA English
DT Article
DE 11 beta-HSD1; knockout mice; glucocorticoids; mouse strain; HPA axis
ID 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1;
   POSTTRAUMATIC-STRESS-DISORDER; GLUCOCORTICOID-RECEPTOR GENE;
   CORTICOTROPIN-RELEASING FACTOR; MAJOR DEPRESSION; MINERALOCORTICOID
   RECEPTOR; METABOLIC SYNDROME; BIPOLAR DISORDER; RAT-BRAIN; NULL MICE
AB Inter-individual differences in hypothalamic-pituitary-adrenal (HPA) axis activity underlie differential vulnerability to neuropsychiatric and metabolic disorders, although the basis of this variation is poorly understood. 11 beta-Hydroxysteroid dehydrogenase type 1 (11 beta-HSD1) has previously been shown to influence HPA axis activity. 129/MF1 mice null for 11 beta-HSD1 (129/MF1 HSD1-/-) have greatly increased adrenal gland size and altered HPA activity, consistent with reduced glucocorticoid negative feedback. On this background, concentrations of plasma corticosterone and adrenocorticotrophic hormone (ACTH) were elevated in unstressed mice, and showed a delayed return to baseline after stress in HSD1-null mice with reduced sensitivity to exogenous glucocorticoid feedback compared to same-background genetic controls. In the present study, we report that the genetic background can dramatically alter this pattern. By contrast to HSD1-/- mice on a 129/MF1 background, HSD1-/- mice congenic on a C57Bl/6J background have normal basal plasma corticosterone and ACTH concentrations and exhibit normal return to baseline of plasma corticosterone and ACTH concentrations after stress. Furthermore, in contrast to 129/MF1 HSD1-/- mice, C57Bl/6J HSD1-/- mice have increased glucocorticoid receptor expression in areas of the brain involved in glucocorticoid negative feedback (hippocampus and paraventricular nucleus), suggesting this may be a compensatory response to normalise feedback control of the HPA axis. In support of this hypothesis, C57Bl/6J HSD1-/- mice show increased sensitivity to dexamethasone-mediated suppression of peak corticosterone. Thus, although 11 beta-HSD1 appears to contribute to regulation of the HPA axis, the genetic background is crucial in governing the response to (and hence the consequences of) its loss. Similar variations in plasticity may underpin inter-individual differences in vulnerability to disorders associated with HPA axis dysregulation. They also indicate that 11 beta-HSD1 inhibition does not inevitably activate the HPA axis.
C1 [Carter, R. N.; Tworowska, U.; Stenvers, D. J.; Seckl, J. R.; Holmes, M. C.] Univ Edinburgh, Queens Med Res Inst, Ctr Cardiovasc Sci, Endocrinol Unit, Edinburgh EH16 4TJ, Midlothian, Scotland.
C3 University of Edinburgh
RP Holmes, MC (corresponding author), Univ Edinburgh, Queens Med Res Inst, Ctr Cardiovasc Sci, Endocrinol Unit, 47 Little France Crescent, Edinburgh EH16 4TJ, Midlothian, Scotland.
EM megan.holmes@ed.ac.uk
RI Seckl, Jonathan/C-3555-2013
FU Wellcome Trust
FX This work was supported by the Wellcome Trust (a Project Grant to M. C.
   H., J.M.P., J.J.M. and J.R.S.; and a programme grant to J.R.S. and
   J.J.M.).
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NR 49
TC 61
Z9 64
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0953-8194
EI 1365-2826
J9 J NEUROENDOCRINOL
JI J. Neuroendocrinol.
PD NOV
PY 2009
VL 21
IS 11
BP 879
EP 887
DI 10.1111/j.1365-2826.2009.01899.x
PG 9
WC Endocrinology & Metabolism; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology
GA 509QD
UT WOS:000271032200002
PM 19602102
OA Green Published
DA 2025-06-11
ER

PT J
AU Dorr, DA
   Quiñones, AR
   King, T
   Wei, MY
   White, K
   Bejan, CA
AF Dorr, David A.
   Quinones, Ana R.
   King, Taylor
   Wei, Melissa Y.
   White, Kellee
   Bejan, Cosmin A.
TI Prediction of Future Health Care Utilization Through Note-extracted
   Psychosocial Factors
SO MEDICAL CARE
LA English
DT Article
DE multimorbidity; psychosocial; biopsychosocial; natural language
   processing
ID SOCIAL DETERMINANTS; ELECTRONIC HEALTH; BIOPSYCHOSOCIAL MODEL; FOOD
   INSECURITY; METABOLIC SYNDROME; MORTALITY; PATIENT; STRESS; RISK; PATH
AB Background: Persons with multimorbidity (>= 2 chronic conditions) face an increased risk of poor health outcomes, especially as they age. Psychosocial factors such as social isolation, chronic stress, housing insecurity, and financial insecurity have been shown to exacerbate these outcomes, but are not routinely assessed during the clinical encounter. Our objective was to extract these concepts from chart notes using natural language processing and predict their impact on health care utilization for patients with multimorbidity. Methods: A cohort study to predict the 1-year likelihood of hospitalizations and emergency department visits for patients 65+ with multimorbidity with and without psychosocial factors. Psychosocial factors were extracted from narrative notes; all other covariates were extracted from electronic health record data from a large academic medical center using validated algorithms and concept sets. Logistic regression was performed to predict the likelihood of hospitalization and emergency department visit in the next year. Results: In all, 76,479 patients were eligible; the majority were White (89%), 54% were female, with mean age 73. Those with psychosocial factors were older, had higher baseline utilization, and more chronic illnesses. The 4 psychosocial factors all independently predicted future utilization (odds ratio=1.27-2.77, C-statistic=0.63). Accounting for demographics, specific conditions, and previous utilization, 3 of 4 of the extracted factors remained predictive (odds ratio=1.13-1.86) for future utilization. Compared with models with no psychosocial factors, they had improved discrimination. Individual predictions were mixed, with social isolation predicting depression and morbidity; stress predicting atherosclerotic cardiovascular disease onset; and housing insecurity predicting substance use disorder morbidity. Discussion: Psychosocial factors are known to have adverse health impacts, but are rarely measured; using natural language processing, we extracted factors that identified a higher risk segment of older adults with multimorbidity. Combining these extraction techniques with other measures of social determinants may help catalyze population health efforts to address psychosocial factors to mitigate their health impacts.
C1 [Dorr, David A.; King, Taylor] Oregon Hlth & Sci Univ, Dept Med Informat & Clin Epidemiol, Portland, OR 97201 USA.
   [Quinones, Ana R.] Oregon Hlth & Sci Univ, Dept Family Med, Portland, OR 97201 USA.
   [Wei, Melissa Y.] UCLA, Sch Med, Los Angeles, CA 90095 USA.
   [White, Kellee] Univ Maryland, Dept Hlth Policy & Management, College Pk, MD USA.
   [Bejan, Cosmin A.] Vanderbilt Univ, Med Ctr, Dept Biomed Informat, 221 Kirkland Hall, Nashville, TN 37235 USA.
C3 Oregon Health & Science University; Oregon Health & Science University;
   University of California System; University of California Los Angeles;
   University of California Los Angeles Medical Center; David Geffen School
   of Medicine at UCLA; University System of Maryland; University of
   Maryland College Park; Vanderbilt University
RP Dorr, DA (corresponding author), SW Sam Jackson Pkwy Rd,Mailcode MDYMICE, Portland, OR 97239 USA.
EM dorrd@ohsu.edu; kingta@ohsu.edu; mywei@mednet.ucla.edu;
   kwhite20@umd.edu; adi.bejan@vumc.org
RI Bejan, Cosmin/KTH-6881-2024
OI Bejan, Cosmin/0000-0001-5107-0584
CR [Anonymous], Capturing Social  Behavioral Domains  Measures in Electronic Health Records: Phase 2
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NR 53
TC 9
Z9 10
U1 2
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7079
EI 1537-1948
J9 MED CARE
JI Med. Care
PD AUG
PY 2022
VL 60
IS 8
BP 570
EP 578
DI 10.1097/MLR.0000000000001742
PG 9
WC Health Care Sciences & Services; Health Policy & Services; Public,
   Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services; Public, Environmental & Occupational
   Health
GA 2S2CS
UT WOS:000821606400004
PM 35658116
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Masuda, Y
   Ichii, H
   Vaziri, ND
AF Masuda, Yuichi
   Ichii, Hirohito
   Vaziri, Nosratola D.
TI At pharmacologically relevant concentrations intravenous iron
   preparations cause pancreatic beta cell death
SO AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
LA English
DT Article
DE Diabetes; anemia; hemodialysis; chronic kidney disease; glucose
   metabolism; insulin; metabolic syndrome; cardiovascular disease
ID SERUM FERRITIN; OXIDATIVE STRESS; DNA-DAMAGE; SUCROSE; INSULIN; RISK;
   WOMEN; ASSOCIATION; DYSFUNCTION; PREVALENCE
AB Back ground: Overt and subtle iron overload cause diabetes by lowering insulin production and promoting insulin resistance. Via divalent metal transporters pancreatic beta cells take up non-transferrin-bound iron which by catalyzing Fenton reaction can cause oxidative stress. Due to their strict dependence on mitochondrial glucose metabolism and limited antioxidant capacity, beta cells are exquisitely vulnerable to oxidative stress and hence catalytically active iron. Intravenous (IV) iron preparations are routinely used in the management of anemia in patients with end stage renal disease. This has led to an epidemic of iron overload in this population. This study explored the effect of pharmacologically-relevant concentrations of a commonly used IV iron preparation on the beta cells in isolated pancreatic islets. Methods: Isolated rat pancreatic islets were incubated for 24 hours in culture media containing vehicle or pharmacologically-relevant concentration of ferric sucrose and examined for the extent of cell death and oxidative stress. Results: Exposure to iron sucrose resulted in a concentration-dependent oxidative stress and pancreatic islet cell death predominantly affecting beta cells. Conclusions: At pharmacologically-relevant concentrations a commonly used IV iron preparation causes oxidative stress and beta cell death. These findings suggest that indiscriminate use of IV iron may impair insulin production capacity in ESRD patients the majority of whom have Type-2 diabetes.
C1 Univ Calif Irvine, Dept Surg, Orange, CA 92868 USA.
   Univ Calif Irvine, Dept Med, Orange, CA 92868 USA.
C3 University of California System; University of California Irvine;
   University of California System; University of California Irvine
RP Vaziri, ND (corresponding author), Univ Calif Irvine, Irvine Med Ctr, Div Nephrol & Hypertens, Suite 400,City Tower,101 City Dr, Orange, CA 92868 USA.
EM ndvaziri@uci.edu
RI Ichii, Hirohito/AAV-8256-2021
OI Ichii, Hirohito/0000-0002-3635-5773
FU NIH-NCRR [UL1 TR000153, KL2 TR000-147]; Juvenile Diabetes Research
   Foundation International [17-2011-609]
FX This study was in part supported by grants from: NIH-NCRR UL1 TR000153,
   KL2 TR000-147; and the Juvenile Diabetes Research Foundation
   International 17-2011-609.
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NR 42
TC 19
Z9 22
U1 0
U2 5
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 1943-8141
J9 AM J TRANSL RES
JI Am. J. Transl. Res.
PY 2014
VL 6
IS 1
BP 64
EP 70
PG 7
WC Oncology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Research & Experimental Medicine
GA AK3WM
UT WOS:000338355900006
PM 24349622
DA 2025-06-11
ER

PT J
AU Caruso, A
   Nicoletti, F
   Mango, D
   Saidi, A
   Orlando, R
   Scaccianoce, S
AF Caruso, Alessandra
   Nicoletti, Ferdinando
   Mango, Dalila
   Saidi, Amira
   Orlando, Rosamaria
   Scaccianoce, Sergio
TI Stress as risk factor for Alzheimer's disease
SO PHARMACOLOGICAL RESEARCH
LA English
DT Review
DE Stress; Glucocorticoids; Alzheimer's disease; Risk factor; Animal model
ID EARLY-LIFE STRESS; AMYLOID-BETA; GLUCOCORTICOID-RECEPTOR; SYNAPTIC
   DYSFUNCTION; TAU PATHOLOGY; MOUSE MODEL; MINERALOCORTICOID RECEPTOR;
   MISSENSE MUTATIONS; IN-VIVO; BRAIN
AB Prolonged stress predisposes susceptible individuals to a number of physiological disorders including cardiovascular disease, obesity and gastrointestinal disorders, as well as psychiatric and neurodegenerative disorders. Preclinical studies have suggested that manipulation of the glucocorticoid milieu can trigger cellular, molecular and behavioral derangement resembling the hallmarks of Alzheimer's Disease (AD). For example, stress or glucocorticoid administration can increase amyloid beta precursor protein and tau phosphorylation which are involved in synaptic dysfunction and neuronal death associated with AD. Although since AD was first described in 1906 at a conference in Tubingen, Germany by Alois Alzheimer our knowledge of neuropathological and neurochemical alterations of AD has been impressively increased, at present, pharmacotherapy is symptomatic at best and has no influence on the progression of the disorder. It is generally believed that most of the drugs developed as disease modifiers have failed in clinical trials because treatment started too late, i.e., after the clinical onset of AD. Because AD pathology begins several years prior to the clinical diagnosis, it is imperative to identify subjects at high risk to develop the disorder. Consequently, the search for putative risk factors has gained importance. ApoE4, diabetes/metabolic syndrome, cardiovascular disorders, and a low cognitive reserve are established risk factors for AD. The focus of this review is on stress and glucocorticoids as potential factors increasing the risk to develop AD.
C1 [Caruso, Alessandra; Nicoletti, Ferdinando; Orlando, Rosamaria; Scaccianoce, Sergio] Sapienza Univ Roma, Dept Physiol & Pharmacol, Piazzale A Moro 6, I-00185 Rome, Italy.
   [Nicoletti, Ferdinando] IRCCS Neuromed, Pozzilli, Italy.
   [Mango, Dalila; Saidi, Amira] European Brain Res Inst, Pharmacol Synapt Dis Lab, Rome, Italy.
C3 Sapienza University Rome; IRCCS Neuromed
RP Scaccianoce, S (corresponding author), Sapienza Univ Roma, Dept Physiol & Pharmacol, Piazzale A Moro 6, I-00185 Rome, Italy.
EM sergio.scaccianoce@uniroma1.it
RI Mango, Dalila/IZQ-0765-2023; Nicoletti, Ferdinando/T-4898-2019; Orlando,
   Rosamaria/AAA-4139-2021; Nicoletti, Ferdinando/A-2446-2010
OI Mango, Dalila/0000-0003-3358-4068; Orlando,
   Rosamaria/0000-0001-9369-1450; Nicoletti, Ferdinando/0000-0003-0917-443X
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NR 61
TC 72
Z9 77
U1 0
U2 23
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 1043-6618
J9 PHARMACOL RES
JI Pharmacol. Res.
PD JUN
PY 2018
VL 132
BP 130
EP 134
DI 10.1016/j.phrs.2018.04.017
PG 5
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA GL1ZY
UT WOS:000436914000014
PM 29689315
DA 2025-06-11
ER

PT J
AU Kirkwood, JS
   Legette, LL
   Miranda, CL
   Jiang, Y
   Stevens, JF
AF Kirkwood, Jay S.
   Legette, LeeCole L.
   Miranda, Cristobal L.
   Jiang, Yuan
   Stevens, Jan F.
TI A Metabolomics-driven Elucidation of the Anti-obesity Mechanisms of
   Xanthohumol
SO JOURNAL OF BIOLOGICAL CHEMISTRY
LA English
DT Article
ID FATTY-ACID OXIDATION; ADENINE-NUCLEOTIDE TRANSLOCASE; DIET-INDUCED
   OBESITY; HUMULUS-LUPULUS; INSULIN SENSITIVITY; DICARBOXYLIC-ACIDS;
   QUINONE REDUCTASE; STRESS-RESPONSE; LIFE-SPAN; CELLS
AB Mild, mitochondrial uncoupling increases energy expenditure and can reduce the generation of reactive oxygen species (ROS). Activation of cellular, adaptive stress response pathways can result in an enhanced capacity to reduce oxidative damage. Together, these strategies target energy imbalance and oxidative stress, both underlying factors of obesity and related conditions such as type 2 diabetes. Here we describe a metabolomics-driven effort to uncover the anti-obesity mechanism(s) of xanthohumol (XN), a prenylated flavonoid from hops. Metabolomics analysis of fasting plasma from obese, Zucker rats treated with XN revealed decreases in products of dysfunctional fatty acid oxidation and ROS, prompting us to explore the effects of XN on muscle cell bioenergetics. At low micromolar concentrations, XN acutely increased uncoupled respiration in several different cell types, including myocytes. Tetrahydroxanthohumol also increased respiration, suggesting electrophilicity did not play a role. At higher concentrations, XN inhibited respiration in a ROS-dependent manner. In myocytes, time course metabolomics revealed acute activation of glutathione recycling and long term induction of glutathione synthesis as well as several other changes indicative of short term elevated cellular stress and a concerted adaptive response. Based on these findings, we hypothesize that XN may ameliorate metabolic syndrome, at least in part, through mitochondrial uncoupling and stress response induction. In addition, time course metabolomics appears to be an effective strategy for uncovering metabolic events that occur during a stress response.
C1 [Kirkwood, Jay S.; Legette, LeeCole L.; Miranda, Cristobal L.; Stevens, Jan F.] Oregon State Univ, Linus Pauling Inst, Corvallis, OR 97331 USA.
   [Kirkwood, Jay S.; Legette, LeeCole L.; Miranda, Cristobal L.; Stevens, Jan F.] Oregon State Univ, Dept Pharmaceut Sci, Corvallis, OR 97331 USA.
   [Jiang, Yuan] Oregon State Univ, Dept Stat, Corvallis, OR 97331 USA.
C3 Oregon State University; Oregon State University; Oregon State
   University
RP Stevens, JF (corresponding author), Oregon State Univ, Linus Pauling Inst, Linus Pauling Sci Ctr 307, Corvallis, OR 97331 USA.
EM fred.stevens@oregonstate.edu
OI Jiang, Yuan/0000-0001-6409-9159; Stevens, Jan
   Frederik/0000-0002-6348-9347
FU National Institutes of Health [R21AT005294, S10RR027878, P30ES000210];
   Cell Imaging and Analysis Facilities and Services Core of the
   Environmental Health Sciences Center, Oregon State University, NIEHS,
   National Institutes of Health [P30 ES00210]
FX This work was supported, in whole or in part, by National Institutes of
   Health Grants R21AT005294, S10RR027878, and P30ES000210.We thank Dr.
   Chrissa Kioussi (Oregon State University-OSU College of Pharmacy) for
   the C2C12 myocytes and Jeff Morre of the OSU mass spectrometry facility.
   The brown preadipocytes were a kind gift from Dr. Bruce Spiegelman
   (Harvard Medical School Department of Cell Biology). For help with the
   Seahorse XF Analyzer, we acknowledge Justin X. Zhang and Jeffrey A.
   Greenwood, Director, Cell Imaging and Analysis Facilities and Services
   Core of the Environmental Health Sciences Center, Oregon State
   University Grant P30 ES00210, NIEHS, National Institutes of Health.
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NR 65
TC 70
Z9 76
U1 1
U2 34
PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3996 USA
EI 1083-351X
J9 J BIOL CHEM
JI J. Biol. Chem.
PD JUN 28
PY 2013
VL 288
IS 26
BP 19000
EP 19013
DI 10.1074/jbc.M112.445452
PG 14
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 176WB
UT WOS:000321335800036
PM 23673658
OA Green Published
DA 2025-06-11
ER

PT J
AU Acikgoz, N
   Ermis, N
   Yagmur, J
   Muezzinoglu, K
   Karakus, Y
   Cansel, M
   Pekdemir, H
   Ozdemir, R
AF Acikgoz, Nusret
   Ermis, Necip
   Yagmur, Julide
   Muezzinoglu, Kubra
   Karakus, Yasin
   Cansel, Mehmet
   Pekdemir, Hasan
   Ozdemir, Ramazan
TI Uric Acid Level and Its Association with Carotid Intima-Media Thickness
   in Patients with Cardiac Syndrome X
SO MEDICAL PRINCIPLES AND PRACTICE
LA English
DT Article
DE Uric acid; Carotid intima-media thickness; Cardiac syndrome X
ID CORONARY-HEART-DISEASE; ENDOTHELIAL DYSFUNCTION; CARDIOVASCULAR-DISEASE;
   ANGINA-PECTORIS; CHEST-PAIN; RISK; HYPERURICEMIA; INFLAMMATION
AB Objective: The aim of our study was to evaluate serum uric acid level and its relationship with carotid intima-media thickness (CIMT) in patients with cardiac syndrome X (CSX). Subjects and Methods: A total of 50 patients with CSX (28 females/22 males, 51.0 +/- 10.9 years) and 40 controls (27 females/13 males, 53.0 +/- 10.2 years) were included in the study. All subjects underwent a noninvasive stress test and conventional coronary angiography. Serum uric acid levels were measured and B mode ultrasonography was performed to assess CIMT in all subjects. Results: Serum uric acid levels were higher in patients with CSX than in the control subjects (5.1 +/- 1.8 vs. 3.9 +/- 1.3 mg/dl; p = 0.002). The CIMT was higher in patients with CSX than in the control subjects (0.75 +/- 0.18 vs. 0.63 +/- 0.09 mm; p < 0.001). A significant correlation was found between serum uric acid values and CIMT measurements in patients with CSX (r = 0.666, p < 0.001). Conclusions: Serum uric acid levels were higher in patients with CSX and elevated serum uric acid levels were associated with carotid atherosclerosis, thereby indicating that elevated serum uric acid levels might contribute to the development of subclinical atherosclerosis in CSX patients. Copyright (C) 2011 S. Karger AG, Basel
C1 [Acikgoz, Nusret; Ermis, Necip; Yagmur, Julide; Muezzinoglu, Kubra; Karakus, Yasin; Cansel, Mehmet; Pekdemir, Hasan; Ozdemir, Ramazan] Inonu Univ, Dept Cardiol, Coll Med, Malatya, Turkey.
C3 Inonu University
RP Acikgoz, N (corresponding author), Inonu Univ, Dept Cardiol, Coll Med, Malatya, Turkey.
EM nusretacikgoz@hotmail.com
RI Pekdemir, Hasan/ABI-6096-2020; Ermis, Necip/A-5184-2018; Cansel,
   Mehmet/ABI-6324-2020
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NR 28
TC 10
Z9 11
U1 0
U2 0
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1011-7571
EI 1423-0151
J9 MED PRIN PRACT
JI Med. Princ. Pract.
PY 2012
VL 21
IS 2
BP 115
EP 119
DI 10.1159/000332583
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 897BU
UT WOS:000300616900003
PM 22076385
OA gold
DA 2025-06-11
ER

PT J
AU Oliveira, CPMS
   Faintuch, J
   Rascovski, A
   Furuya, CK
   Bastos, MD
   Matsuda, M
   Nina, BI
   Yahnosi, K
   Abdala, DSP
   Vezozzo, DCP
   Alves, VAF
   Zilberstein, B
   Garrido, AB
   Halpern, A
   Carrilho, FJ
   Gama-Rodrigues, JJ
AF Oliveira, CPMS
   Faintuch, J
   Rascovski, A
   Furuya, CK
   Bastos, MD
   Matsuda, M
   Nina, BI
   Yahnosi, K
   Abdala, DSP
   Vezozzo, DCP
   Alves, VAF
   Zilberstein, B
   Garrido, AB
   Halpern, A
   Carrilho, FJ
   Gama-Rodrigues, JJ
TI Lipid peroxidation in bariatric candidates with nonalcoholic fatty liver
   disease (NAFLD) preliminary findings
SO OBESITY SURGERY
LA English
DT Article
DE morbid obesity; nonalcoholic steatohepatitis; fatty liver; oxidative
   stress; bariatric surgery; metabolic syndrome
ID OXIDATIVE STRESS; STEATOHEPATITIS; PATHOGENESIS
AB Background: Pathogenesis of nonalcoholic fatty liver disease (NAFLD) remains incompletely known, and oxidative stress is one of the mechanisms incriminated. The aim of this study was to evaluate the role of liver oxidative stress in NAFLD affecting morbidly obese patients.
   Methods: 39 consecutive patients with BMI > 40 kg/m(2) submitted to Roux-en-Y gastric bypass were enrolled, and wedge liver biopsy was obtained during operation. Oxidative stress was measured by concentration of hydroperoxides (CEOOH) in liver tissue.
   Results: Female gender was dominant (89.7%) and median age was 43.6 +/- 11.1 years. Histology showed fatty liver in 92.3%, including 43.6% with nonalcoholic steatohepatitis (NASH), 48.7% with isolated steatosis and just 7.7% with normal liver. Liver cirrhosis was present in 11.7% of those with nonalcoholic steatohepatitis. Concentration of CEOOH was increased in the liver of patients with NASH when compared to isolated steatosis and normal liver (0.26 +/- 0.17, 0.20 +/- 0.01 and 0.14 +/- 0.00 nmol/mg protein, respectively) (P < 0.01). Liver biochemical variables were normal in 92.3% of all cases, and no difference between NASH and isolated steatosis could be demonstrated.
   Conclusions: 1) Nonalcoholic steatosis, steatohepatitis and cirrhosis were identified in substantial numbers of morbidly obese patients; 2) Concentration of hydroperoxides was increased in steatohepatitis, consistent with a pathogenetic role for oxidative stress in this condition.
C1 Univ Sao Paulo, Sch Med, Dept Gastroenterol, BR-05508 Sao Paulo, Brazil.
   Univ Sao Paulo, Sch Med, Dept Endocrinol, BR-05508 Sao Paulo, Brazil.
   Univ Sao Paulo, Sch Med, Dept Pathol, BR-05508 Sao Paulo, Brazil.
   Univ Sao Paulo, Sch Pharmaceut Sci, Dept Clin Toxicol Anal, Sao Paulo, Brazil.
C3 Universidade de Sao Paulo; Universidade de Sao Paulo; Universidade de
   Sao Paulo; Universidade de Sao Paulo
RP Av Eneias Ccarvalho Aguiar,255-ICHC-Sala 9159, BR-05403900 Sao Paulo, SP, Brazil.
RI Carrilho, Flair/I-3046-2012; Zilberstein, Bruno/K-2087-2016; Oliveira,
   Claudia/D-1216-2014
OI Carrilho, Flair Jose/0000-0002-7682-3105; P Oliveira,
   Claudia/0000-0002-2848-417X; Castelo Branco de Oliveira Bastos, Maria do
   Socorro/0000-0001-6283-0446; Alves, Venancio/0000-0001-5285-4460
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   Chitturi S, 2001, SEMIN LIVER DIS, V21, P27, DOI 10.1055/s-2001-12927
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NR 22
TC 38
Z9 39
U1 0
U2 9
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0960-8923
EI 1708-0428
J9 OBES SURG
JI Obes. Surg.
PD APR
PY 2005
VL 15
IS 4
BP 502
EP 505
DI 10.1381/0960892053723493
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 923LI
UT WOS:000228911000008
PM 15946429
DA 2025-06-11
ER

EF﻿FN Clarivate Analytics Web of Science
VR 1.0
PT J
AU Kilic-Toprak, E
   Yaylali, O
   Yaylali, YT
   Ozdemir, Y
   Yuksel, D
   Senol, H
   Sengoz, T
   Bor-Kucukatay, M
AF Kilic-Toprak, Emine
   Yaylali, Olga
   Yaylali, Yalin Tolga
   Ozdemir, Yasin
   Yuksel, Dogangun
   Senol, Hande
   Sengoz, Tarik
   Bor-Kucukatay, Melek
TI Hemorheological dysfunction in cardiac syndrome X
SO ACTA CARDIOLOGICA
LA English
DT Article
DE Erythrocyte aggregation; cardiac syndrome X; red blood cell
   deformability; plasma viscosity; microvascular angina
ID CELL DISTRIBUTION WIDTH; ACUTE MYOCARDIAL-INFARCTION; BLOOD RHEOLOGY;
   OXIDATIVE STRESS; ERYTHROCYTE DEFORMABILITY; MICROVASCULAR ANGINA;
   PLASMA VISCOSITY; HEART-FAILURE; AGGREGATION; DISEASE
AB Background: Cardiac syndrome X (CSX) is often described as angina or angina-like chest pain with a normal coronary arteriogram, yet the underlying pathophysiological mechanisms have not been fully elucidated. The aim of the current study was to determine alterations in blood rheology (erythrocyte aggregation and deformability, plasma viscosity - PV) in patients with CSX.
   Methods: The study comprised 26 CSX patients (55.7712.33 years) and 37 age- and sex-matched (56.3211.98 years) healthy controls. Erythrocyte aggregation and deformability were measured by an ektacytometer and PV with a rotational viscometer.
   Results: Erythrocyte deformability measured at 1.69 and 3.00 Pa was lower in the CSX patients compared to the controls (p = .0001 and .017, respectively). Erythrocyte aggregation index (AI) (72.758 +/- 7.65 vs. 66.483 +/- 6.63, p = .002) and PV measured at a shear rate of 375 s(-1) (1.932 +/- 0.225 vs. 1.725 +/- 0.331, p = .019) were significantly higher in patients with CSX. When AI, RDW and erythrocyte deformability measured at 1.69 Pa were evaluated together, it was observed that the increase in AI and RDW augments the risk of having CSX (OR: 1.2 and 2.65, respectively), while the rise in deformability decreases this risk (OR = 0.02).
   Conclusions: Hemorheological impairments are associated with CSX.
C1 [Kilic-Toprak, Emine; Ozdemir, Yasin; Bor-Kucukatay, Melek] Pamukkale Univ, Dept Physiol, Fac Med, TR-20070 Kinikli, Denizli, Turkey.
   [Yaylali, Olga; Yuksel, Dogangun; Sengoz, Tarik] Pamukkale Univ, Dept Nucl Med, Fac Med, Kinikli, Denizli, Turkey.
   [Yaylali, Yalin Tolga] Pamukkale Univ, Dept Cardiol, Fac Med, Kinikli, Denizli, Turkey.
   [Senol, Hande] Pamukkale Univ, Dept Biostat, Fac Med, Kinikli, Denizli, Turkey.
C3 Pamukkale University; Pamukkale University; Pamukkale University;
   Pamukkale University
RP Kilic-Toprak, E (corresponding author), Pamukkale Univ, Dept Physiol, Fac Med, TR-20070 Kinikli, Denizli, Turkey.
EM pt_emine@yahoo.com
RI Yaylali, Yalin/ABI-4603-2020; Yüksel, Doğangün/AAA-6085-2021; Sengoz,
   Tarik/JWP-6654-2024
OI YUKSEL, DOGANGUN/0000-0003-0983-2834
FU Pamukkale University Scientific Research Projects Coordination Unit
   [2015HZL019]
FX This work was supported by the Pamukkale University Scientific Research
   Projects Coordination Unit under Grant number 2015HZL019.
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NR 47
TC 3
Z9 3
U1 0
U2 5
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0001-5385
EI 1784-973X
J9 ACTA CARDIOL
JI Acta Cardiol.
PY 2018
VL 73
IS 3
BP 257
EP 265
DI 10.1080/00015385.2017.1373967
PG 9
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA GJ1FT
UT WOS:000435000800006
PM 28889793
DA 2025-06-11
ER

PT J
AU Horimoto, M
   Sakuragi, H
   Takenaka, T
   Inoue, H
   Igarashi, K
AF Horimoto, M
   Sakuragi, H
   Takenaka, T
   Inoue, H
   Igarashi, K
TI Microvascular angina accompanied by epicardial coronary artery spasm
SO INTERNAL MEDICINE
LA English
DT Article
DE acetylcholine; coronary flow reserve; amlodipine; nicorandil
ID SYNDROME-X; VASODILATOR RESERVE; CHEST PAIN; ISCHEMIA; PECTORIS; THERAPY
AB A case of microvascular angina accompanied by coronary artery spasm is described. A 54-year-old woman had anginal pain at rest and during exercise. Both exercise testing and rapid atrial pacing caused significant ST depression in the inferior and all precordial leads. Exercise thallium myocardial scintigraphy was negative despite similar ST depressions. Coronary angiography revealed insignificant stenoses of the left anterior descending coronary artery after the injection of nitrate. Intracoronary acetylcholine provoked diffuse spasm of the artery with concurrent myocardial lactate production. Coronary flow reserve assessed with papaverine was 2.75. The combined use of amlodipine and high-dose nicorandil was effective for the treatment of angina.
C1 Chitose City Gen Hosp, Div Cardiol, Chitose, Hokkaido 0668550, Japan.
RP Horimoto, M (corresponding author), Chitose City Gen Hosp, Div Cardiol, 1-11 Shinonome Cho, Chitose, Hokkaido 0668550, Japan.
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NR 14
TC 2
Z9 2
U1 0
U2 0
PU JAPAN SOC INTERNAL MEDICINE
PI TOKYO
PA 34-3 3-CHOME HONGO BUNKYO-KU, TOKYO, 113, JAPAN
SN 0918-2918
J9 INTERNAL MED
JI Intern. Med.
PD MAR
PY 2002
VL 41
IS 3
BP 216
EP 220
DI 10.2169/internalmedicine.41.216
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 533DH
UT WOS:000174513800010
PM 11929184
DA 2025-06-11
ER

PT J
AU Rosen, SD
   Camici, PG
AF Rosen, SD
   Camici, PG
TI The brain-heart axis in the perception of cardiac pain: the elusive link
   between ischaemia and pain
SO ANNALS OF MEDICINE
LA English
DT Article; Proceedings Paper
CT XVIth Symposium of the Signe and Ane Gyllenberg Foundation on
   Psychosomatic Cardiology
CY MAY, 1999
CL ESPOO, FINLAND
SP Finnish Cardiac Soc
DE angina; myocardial ischaemia; positron emission tomography; syndrome X;
   visceral pain
ID SILENT-MYOCARDIAL-ISCHEMIA; NORMAL CORONARY-ARTERIES; CHEST PAIN;
   ANGINA-PECTORIS; SYNDROME-X; CORTEX; MECHANISMS; EXERCISE; PATHWAYS; RAT
AB Angina pectoris is a common symptom and one that can have profound implications for the patient. However, it correlates poorly with the extent of myocardial ischaemia and with prognosis. In order to understand more fully the heterogeneity of the experience of chest pain, we have adopted the technique of functional neuroimaging, where positron emission tomography is used to measure regional cerebral blood flow as an index of regional neuronal activation, during myocardial ischaemia in patients with coronary artery disease. Fire have been able to delineate those brain areas that are involved in the perception of angina: the hypothalamus, periaquaductal grey, thalami and bilaterally the prefrontal cortex and in the left the inferior anterocaudal cingulate cortex. By studying patients with silent myocardial ischaemia, we have established that the silence is not merely a matter of impaired afferent signalling resulting from autonomic neuropathy, but that it is associated with a failure of transmission of signals from the thalamus to the frontal cortex. At the other end of the spectrum, we have studied patients with syndrome X, a condition of chest pain with ischaemic-like stress electrocardiography (ECG) but entirely normal coronary angiogram; ton the basis of our own and other data we consider an ischaemic aetiology to be most unlikely in this condition). In syndrome X, distinct patterns of cerebral activation were found with characteristic activation of the right anterior insula at its junction with the frontal operculum. In conclusion, we present a unified view of the cerebral handling of afferent signals from the heart throughout this spectrum of experience of chest pain, a view that accounts for the clinical features of the patients studied.
C1 Hammersmith Hosp, MRC, Cyclotron Unit, London W12 0NN, England.
   Univ London Imperial Coll Sci Technol & Med, Sch Med, London, England.
C3 Imperial College London; Imperial College London
RP Hammersmith Hosp, MRC, Cyclotron Unit, Du Cane Rd, London W12 0NN, England.
EM SDandA.Rosen@btinternet.com
RI Rosen, Stuart/AAE-4649-2020; Camici, Paolo/AAN-1959-2020
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NR 61
TC 35
Z9 42
U1 0
U2 1
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0785-3890
EI 1365-2060
J9 ANN MED
JI Ann. Med.
PD JUL
PY 2000
VL 32
IS 5
BP 350
EP 364
DI 10.3109/07853890008995938
PG 15
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC General & Internal Medicine
GA 339BB
UT WOS:000088456800009
PM 10949067
OA Bronze
DA 2025-06-11
ER

PT J
AU Briana, DD
   Boutsikou, M
   Boutsikou, T
   Dodopoulos, T
   Gourgiotis, D
   Malamitsi-Puchner, A
AF Briana, Despina D.
   Boutsikou, Maria
   Boutsikou, Theodora
   Dodopoulos, Thanasis
   Gourgiotis, Dimitrios
   Malamitsi-Puchner, Ariadne
TI Plasma copeptin may not be a sensitive marker of perinatal stress in
   healthy full-term growth-restricted fetuses
SO JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
LA English
DT Article
DE AVP; copeptin; cord blood; insulin; intrauterine growth restriction
ID CORD BLOOD; FETAL-GROWTH; METABOLIC SYNDROME; DIABETES-MELLITUS; VAGINAL
   DELIVERY; GESTATIONAL-AGE; BIRTH-WEIGHT; VASOPRESSIN; INFANTS; GLUCOSE
AB Objective: Intrauterine-growth-restriction-(IUGR) is associated with chronic fetal stress, as well as a phase of enhanced fetal/early postnatal insulin sensitivity, followed by a later emergence of insulin resistance. We aimed to prospectively investigate concentrations of copeptin, a sensitive marker of stress and insulin resistance, in IUGR versus appropriate-for-gestational-age-(AGA) fetuses.
   Methods: Cord blood copeptin concentrations were determined by ELISA in well-defined, non-distressed at birth, asymmetric IUGR (n=30) and AGA (n=20) full-term pregnancies. Doppler studies were indicative of placental insufficiency.
   Results: Cord blood copeptin concentrations were similar in IUGR cases and AGA controls, after controlling for delivery mode. Copeptin concentrations were markedly elevated in vaginally delivered fetuses (p=0.001). No association was recorded between fetal copeptin concentrations and maternal age, parity, gestational age, or fetal gender.
   Conclusions: Cord blood copeptin concentrations are probably not affected by IUGR at term, in the absence of fetal distress, possibly due to a balance between copeptin up-regulation by chronic fetal stress, on one hand, and copeptin down-regulation in the presence of increased insulin sensitivity, on the other hand; thus, copeptin may not be a sensitive marker of chronic perinatal stress in healthy asymmetric IUGR infants. Cord blood copeptin seems to primarily reflect perinatal stress associated with delivery mode.
C1 [Briana, Despina D.; Boutsikou, Maria; Boutsikou, Theodora; Malamitsi-Puchner, Ariadne] Univ Athens, Dept Neonatol, 19 Soultani St, Athens 10682, Greece.
   [Dodopoulos, Thanasis; Gourgiotis, Dimitrios] Univ Athens, Dept Pediat 2, Lab Clin Biochem Mol Diagnost, Athens, Greece.
C3 National & Kapodistrian University of Athens; National & Kapodistrian
   University of Athens
RP Malamitsi-Puchner, A (corresponding author), Univ Athens, Dept Neonatol, 19 Soultani St, Athens 10682, Greece.
EM amalpu@med.uoa.gr
RI Boutsikou, Maria/AAX-7289-2020
CR [Anonymous], J MATERN FETAL NEONA
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NR 30
TC 4
Z9 4
U1 0
U2 7
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1476-7058
EI 1476-4954
J9 J MATERN-FETAL NEO M
JI J. Matern.-Fetal Neonatal Med.
PD MAR
PY 2017
VL 30
IS 6
BP 705
EP 709
DI 10.1080/14767058.2016.1183632
PG 5
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA EJ5ZI
UT WOS:000393297500014
PM 27125294
DA 2025-06-11
ER

PT J
AU Bragagna, L
   Polak, C
   Schuetz, L
   Maqboul, L
   Klammer, C
   Feldbauer, R
   Draxler, A
   Clodi, M
   Wagner, KH
AF Bragagna, Laura
   Polak, Christina
   Schuetz, Lisa
   Maqboul, Lina
   Klammer, Carmen
   Feldbauer, Roland
   Draxler, Agnes
   Clodi, Martin
   Wagner, Karl-Heinz
TI Effect of Repeated Bolus and Continuous Glucose Infusion on DNA Damage
   and Oxidative Stress Biomarkers in Healthy Male Volunteers
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE glucose variability; glucose; type 2 diabetes; oxidative stress;
   hyperglycemia; DNA damage; comet assay; protein carbonyls; bilirubin;
   antioxidants; ROS
ID DIABETES-MELLITUS; BILIRUBIN; PATHWAY; DISEASE; RISK; AGE
AB Glucose variability (GV), which describes fluctuations in blood glucose levels within the day, is a phenomenon that is increasingly becoming the target of scientific attention when it comes to increased risk of coronary heart disease. Effects of GV may contribute to the development of metabolic syndrome and type 2 diabetes. Hyperglycemia can lead to oxidative stress resulting in molecular damage due to accumulation of reactive oxygen species (ROS). To discover more about the immediate effects of GV, continuous vs. bolus intravenous glucose administration was applied to 10 healthy men aged 21-30 years over a time frame of 48 h. Whole blood and plasma were analyzed for DNA damage using a comet assay with 3 different treatments (lysis buffer, H2O2, and the lesion-specific enzyme formamidopyrimidine DNA glycosylase (FPG)) as well as for the oxidative stress markers protein carbonyls (PC), unconjugated bilirubin (UCB), and ferric reducing antioxidant power (FRAP). A significant time effect was found in the three DNA damage treatments as well as in PC and UCB possibly due to circadian changes on oxidative stress, but no intervention group effect was observed for any of the markers. In conclusion, bolus vs. continuous glucose administration had no significant acute effect on DNA damage and markers of oxidative stress in healthy men.
C1 [Bragagna, Laura; Polak, Christina; Schuetz, Lisa; Maqboul, Lina; Draxler, Agnes; Wagner, Karl-Heinz] Univ Vienna, Dept Nutr Sci, A-1090 Vienna, Austria.
   [Bragagna, Laura; Klammer, Carmen; Draxler, Agnes] Univ Vienna, Vienna Doctoral Sch Pharmaceut Nutr & Sport Sci, A-1090 Vienna, Austria.
   [Klammer, Carmen; Feldbauer, Roland; Clodi, Martin] St John God Hosp Linz, Dept Internal Med, A-4020 Linz, Austria.
   [Klammer, Carmen; Clodi, Martin] Johannes Kepler Univ Linz JKU Linz, ICMR Inst Cardiovasc & Metab Res, A-4040 Linz, Austria.
C3 University of Vienna; University of Vienna
RP Wagner, KH (corresponding author), Univ Vienna, Dept Nutr Sci, A-1090 Vienna, Austria.
EM laura.bragagna@univie.ac.at; lina.maqboul@univie.ac.at;
   carmen.klammer@bblinz.at; roland.feldbauer@bblinz.at;
   agnes.draxler@univie.ac.at; martin.clodi@bblinz.at;
   karl-heinz.wagner@univie.ac.at
RI Schuetz, Lisa Theresia/AFK-2053-2022; Wagner, Karl-Heinz/B-9098-2013
OI Wagner, Karl-Heinz/0000-0002-1683-7265; Maqboul,
   Lina/0009-0000-6080-886X; Bragagna, Laura/0000-0002-8676-3863; Draxler,
   Agnes/0000-0001-9750-4149
FU We want to thank Gina Varnavides for support in the lab.
FX We want to thank Gina Varnavides for support in the lab.
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NR 40
TC 1
Z9 1
U1 0
U2 7
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD SEP
PY 2023
VL 24
IS 17
AR 13608
DI 10.3390/ijms241713608
PG 12
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA Q9JH6
UT WOS:001060602400001
PM 37686414
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Ding, JX
   Wu, LL
   Zhu, GX
   Zhu, J
   Luo, PP
   Li, YM
AF Ding, Jiexia
   Wu, Lili
   Zhu, Guoxian
   Zhu, Jing
   Luo, Pingping
   Li, Youming
TI HADHA alleviates hepatic steatosis and oxidative stress in NAFLD via
   inactivation of the MKK3/MAPK pathway
SO MOLECULAR BIOLOGY REPORTS
LA English
DT Article
DE HADHA; Nonalcoholic fatty liver disease; Lipid metabolism; Oxidative
   stress; MKK3; MAPK
ID NONALCOHOLIC STEATOHEPATITIS; LIVER-DISEASE; INFLAMMATION; DEFICIENCY
AB Background Nonalcoholic fatty liver disease (NAFLD) is a liver metabolic syndrome and still lacks effective treatments because the molecular mechanism underlying the development of NAFLD is not completely understood. We investigated the role of Hydroxyl CoA dehydrogenase alpha subunit (HADHA) in the pathogenesis of NAFLD. Methods HADHA expression was detected both in NAFLD cell and mice, and knockdown of HADHA in free fatty acids (FFA)-treated L02 or overexpression of HADHA in high fat diet (HFD)-fed mice was used to detected the influence of HADHA on hepatic steatosis, mitochondrial dysfunction, and oxidative stress by regulating of MKK3/MAPK signaling. Results Our data revealed that HADHA expression was decreased in FFA-treated L02 cells and in HFD-fed mice. Knockdown of HADHA markedly aggravated hepatic steatosis, inflammation and oxidative stress in FFA-treated L02 cells, which was associated with the activation of MKK3/MAPK signalling pathways. Moreover, oxidative stress and liver lesions were improved in NAFLD mice by upregulation of HADHA. Importantly, we demonstrated that overexpression of HADHA inhibited the expression of p-MAPK in NAFLD mice, reducing lipid accumulation and steatosis. Conclusion HADHA may function as a protective factor in the progression of NAFLD by alleviating abnormal metabolism and oxidative stress by suppressing MKK3/MAPK signalling pathway activation, providing a new target for the treatment of NAFLD.
C1 [Ding, Jiexia; Zhu, Guoxian; Zhu, Jing; Luo, Pingping] Zhejiang Univ, Affiliated Hangzhou Peoples Hosp 1, Dept Infect Dis, Sch Med, 261 Huansha Rd, Hangzhou 310003, Zhejiang, Peoples R China.
   [Wu, Lili] Ruian City Peoples Hosp, Dept Oncol, Ruian 325200, Peoples R China.
   [Li, Youming] Zhejiang Univ, Sch Med, Affiliated Hosp 1, Dept Gastroenterol, Hangzhou 310003, Peoples R China.
C3 Zhejiang University; Zhejiang University
RP Ding, JX (corresponding author), Zhejiang Univ, Affiliated Hangzhou Peoples Hosp 1, Dept Infect Dis, Sch Med, 261 Huansha Rd, Hangzhou 310003, Zhejiang, Peoples R China.
EM 10918053@zju.edu.cn
RI Wu, lili/GQH-6998-2022; li, youming/GYJ-2598-2022; Luo,
   Pingping/V-3234-2019
FU Zhejiang Provincial Natural Science Foundation of China [LQ18H070006];
   Zhejiang Provincial Medical and Health Technology Project [2019RC069]
FX We sincerely appreciate the investigators and authors who have
   contributed to this field. This research was supported by the Zhejiang
   Provincial Natural Science Foundation of China under Grant No.
   LQ18H070006 and the Zhejiang Provincial Medical and Health Technology
   Project (Grant No. 2019RC069).
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NR 50
TC 11
Z9 11
U1 1
U2 18
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0301-4851
EI 1573-4978
J9 MOL BIOL REP
JI Mol. Biol. Rep.
PD FEB
PY 2023
VL 50
IS 2
BP 961
EP 970
DI 10.1007/s11033-022-07965-2
EA NOV 2022
PG 10
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA A5YI7
UT WOS:000883222600002
PM 36376538
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Borujeni, MJS
   Esfandiary, E
   Baradaran, A
   Valiani, A
   Ghanadian, M
   Codoñer-Franch, P
   Basirat, R
   Alonso-Iglesias, E
   Mirzaei, H
   Yazdani, A
AF Borujeni, Mohammad Javad Saeedi
   Esfandiary, Ebrahim
   Baradaran, Azar
   Valiani, Ali
   Ghanadian, Mustafa
   Codoner-Franch, Pilar
   Basirat, Reyhane
   Alonso-Iglesias, Eulalia
   Mirzaei, Hamed
   Yazdani, Amid
TI Molecular aspects of pancreatic β-cell dysfunction: Oxidative stress,
   microRNA, and long noncoding RNA
SO JOURNAL OF CELLULAR PHYSIOLOGY
LA English
DT Review
DE microRNAs; noncoding RNAs; oxidative stress; pancreatic beta-cell
   dysfunction; type 2 diabetes mellitus
ID FREE FATTY-ACIDS; GLUCOSE-REGULATED ANAPLEROSIS; TYPE-2
   DIABETES-MELLITUS; GLYCATION END-PRODUCTS; TUMOR-NECROSIS-FACTOR;
   INSULIN-RESISTANCE; CIRCULATING MICRORNAS; ADIPOSE-TISSUE; TNF-ALPHA;
   OXIDANT/ANTIOXIDANT STATUS
AB Metabolic syndrome is known as a frequent precursor of type 2 diabetes mellitus (T2D). This disease could affect 8% of the people worldwide. Given that pancreatic beta-cell dysfunction and loss have central roles in the initiation and progression of the disease, the understanding of cellular and molecular pathways associated with pancreatic beta-cell dysfunction can provide more information about the underlying pathways involved in T2D. Multiple lines evidence indicated that oxidative stress, microRNA, and long noncoding RNA play significant roles in various steps of diseases. Oxidative stress is one of the important factors involved in T2D pathogenesis. This could affect the function and survival of the beta cell via activation or inhibition of several processes and targets, such as receptor-signal transduction, enzyme activity, gene expression, ion channel transport, and apoptosis. Besides oxidative stress, microRNAs and noncoding RNAs have emerged as epigenetic regulators that could affect pancreatic beta-cell dysfunction. These molecules exert their effects via targeting a variety of cellular and molecular pathways involved in T2D pathogenesis. Here, we summarized the molecular aspects of pancreatic beta-cell dysfunction. Moreover, we highlighted the roles of oxidative stress, microRNAs, and noncoding RNAs in pancreatic beta-cell dysfunction.
C1 [Borujeni, Mohammad Javad Saeedi; Esfandiary, Ebrahim; Valiani, Ali] Isfahan Univ Med Sci, Sch Med, Dept Anat Sci & Mol Biol, Esfahan, Iran.
   [Baradaran, Azar] Isfahan Univ Med Sci, Sch Med, Dept Pathol, Esfahan, Iran.
   [Ghanadian, Mustafa] Isfahan Univ Med Sci, Fac Pharm & Pharmaceut Sci, Dept Pharmacol, Esfahan, Iran.
   [Codoner-Franch, Pilar] Univ Valencia, Dept Pediat Obstet & Gynecol, Valencia, Spain.
   [Basirat, Reyhane] Shiraz Univ Med Sci, Sch Nutr & Food Sci, Dept Clin Nutr, Shiraz, Iran.
   [Alonso-Iglesias, Eulalia] Univ Valencia, Dept Biochem & Mol Biol, Valencia, Spain.
   [Mirzaei, Hamed] Kashan Univ Med Sci, Res Ctr Biochem & Nutr Metab Dis, Kashan, Iran.
   [Yazdani, Amid] Isfahan Univ Med Sci, Sch Med, Esfahan, Iran.
C3 Isfahan University of Medical Sciences; Isfahan University of Medical
   Sciences; Isfahan University of Medical Sciences; University of
   Valencia; Shiraz University of Medical Science; University of Valencia;
   Isfahan University of Medical Sciences
RP Esfandiary, E (corresponding author), Isfahan Univ Med Sci, Sch Med, Dept Anat Sci & Mol Biol, Esfahan, Iran.
EM esfandiari@med.mui.ac.ir
RI Yazdani, Amid/AAW-7688-2021; /L-9758-2014; baradaran, azar/V-6360-2017;
   Mirzaee, Hamidreza/AAU-8999-2021; valiani, ali/V-7638-2017;
   Codoner-Franch, Pilar/K-9333-2014; Ghanadian, Mustafa/H-4702-2011
OI mirzaei, hamed/0000-0002-9399-8281; saeedi borujeni, mohammad
   javad/0000-0002-4075-5390; Codoner-Franch, Pilar/0000-0002-1549-1573;
   Ghanadian, Mustafa/0000-0001-6446-4734; Yazdani,
   Amid/0000-0002-1123-270X
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NR 183
TC 66
Z9 66
U1 0
U2 32
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0021-9541
EI 1097-4652
J9 J CELL PHYSIOL
JI J. Cell. Physiol.
PD JUN
PY 2019
VL 234
IS 6
BP 8411
EP 8425
DI 10.1002/jcp.27755
PG 15
WC Cell Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Physiology
GA HM2QU
UT WOS:000459314500064
PM 30565679
DA 2025-06-11
ER

PT J
AU Fernando, HA
   Chin, HF
   Ton, SH
   Kadir, KA
AF Fernando, Hamish Alexander
   Chin, Hsien-Fei
   Ton, So Ha
   Kadir, Khalid Abdul
TI Stress and Its Effects on Glucose Metabolism and 11β-HSD Activities in
   Rats Fed on a Combination of High-Fat and High-Sucrose Diet with
   Glycyrrhizic Acid
SO JOURNAL OF DIABETES RESEARCH
LA English
DT Article
ID 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1; ACTIVATED RECEPTOR-GAMMA;
   INSULIN SENSITIVITY; GLUCOCORTICOID-RECEPTOR; ADIPOSE-TISSUE;
   BLOOD-PRESSURE; PEROXISOME PROLIFERATOR; LIPOPROTEIN-LIPASE; HUMAN
   KIDNEY; EXPRESSION
AB Chronic stress has been shown to have a strong link towards metabolic syndrome (MetS). Glycyrrhizic acid (GA) meanwhile has been shown to improve MetS symptoms caused by an unhealthy diet by inhibiting 11 beta-HSD 1. This experiment aimed to determine the effects of continuous, moderate-intensity stress on rats with and without GA intake on systolic blood pressure (SBP) across a 28-day period, as well as glucose metabolism, and 11 beta-HSD 1 and 2 activities at the end of the 28-day period. Adaptation to the stressor (as shown by SBP) resulted in no significant defects in glucose metabolism by the end of the experimental duration. However, a weakly significant increase in renal 11 beta-HSD 1 and a significant increase in subcutaneous adipose tissue 11 beta-HSD 1 activities were observed. GA intake did not elicit any significant benefit in glucose metabolism, indicating that the stress response may block its effects. However, GA-induced improvements in 11 beta-HSD activities in certain tissues were observed, although it is uncertain if these effects are manifested after adaptation due to the withdrawal of the stress response. Hence the ability of GA to improve stress-induced disturbances in the absence of adaptation needs to be investigated further.
C1 [Fernando, Hamish Alexander; Chin, Hsien-Fei; Ton, So Ha; Kadir, Khalid Abdul] Monash Univ, Bandar Sunway 46150, Selangor Darul, Malaysia.
C3 Monash University; Monash University Malaysia
RP Fernando, HA (corresponding author), Monash Univ, Sunway Campus,Jalan Lagoon Selatan, Bandar Sunway 46150, Selangor Darul, Malaysia.
EM hf.hamishfernando@gmail.com; ton.so.ha@monash.edu
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NR 100
TC 13
Z9 13
U1 0
U2 9
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2314-6745
EI 2314-6753
J9 J DIABETES RES
JI J. Diabetes Res.
PY 2013
VL 2013
AR 190395
DI 10.1155/2013/190395
PG 18
WC Endocrinology & Metabolism; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Research & Experimental Medicine
GA 139TV
UT WOS:000318608600001
PM 23671857
OA Green Accepted, gold, Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Smith, GP
   Schwartz, GJ
AF Smith, Gerard P.
   Schwartz, Gary J.
TI Randall Sakai, chronic social stress, and the research tradition of Curt
   Richter
SO PHYSIOLOGY & BEHAVIOR
LA English
DT Review
DE Chronic social stress; Subordinate stress; Fat distribution; Metabolic
   stress; Curt Richter; Research tradition; Mentoring
ID NORWAY RAT; BRAIN
AB This paper describes Randall Sakai's professional career from graduate school at the University of Pennsylvania, through postdoctoral work at Rockefeller University, and to being an independent investigator at the University of Cincinnati. He was fortunate in having Alan Epstein, Bruce McEwen, and Eliot Stellar as mentors. Early in Sakai's graduate work, Epstein and Stellar introduced him to Curt Richter, the legendary investigator at Johns Hopkins. This early introduction to Richter and his tradition of research was crucial for Sakai's scientific development. We review Sakai's research with the Visible Burrowing System (VBS) at Cincinnati. This was the most original of Sakai's research interests. His experimental proficiency in the investigation of salt appetite, food intake, and obesity led him to focus on the effect of chronic social stress on food intake, body composition, metabolism, and the distribution of fat. He and his colleagues, many of them his students, were able to demonstrate that chronic social stress produced changes in metabolism and fat distribution that were characteristic of an incipient metabolic syndrome that could lead to obesity. This did not solve the problem, but showed the way to further investigation. This opening up of problems to experimental investigation was a hallmark of Richter's research. Thus, Sakai worked in the mainstream of the research tradition of Richter. He did what he revered. (C) 2017 Elsevier Inc. All rights reserved.
C1 [Smith, Gerard P.] Weill Cornell Med Coll, Dept Psychiat, New York, NY 10065 USA.
   [Schwartz, Gary J.] Albert Einstein Coll Med, Dept Med, Bronx, NY 10467 USA.
   [Schwartz, Gary J.] Albert Einstein Coll Med, Dept Neurosci, Bronx, NY 10467 USA.
C3 Cornell University; Weill Cornell Medicine; Montefiore Medical Center;
   Albert Einstein College of Medicine; Yeshiva University; Montefiore
   Medical Center; Albert Einstein College of Medicine; Yeshiva University
RP Smith, GP (corresponding author), Weill Cornell Med Coll, Dept Psychiat, New York, NY 10065 USA.
EM gpsmith@med.cornell.edu
FU NIH [DK026687]
FX GPS thanks Marica Miller for expert bibliographic assistance, his
   chairman, Jack Barchas, for continued support, and Dr. Kellie Tamashiro
   for lending me a copy of Sakai's graduate thesis and sharing her
   remembrances of him. GJS supported by NIH DK026687.
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NR 23
TC 0
Z9 0
U1 0
U2 4
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0031-9384
J9 PHYSIOL BEHAV
JI Physiol. Behav.
PD SEP 1
PY 2017
VL 178
SI SI
BP 2
EP 6
DI 10.1016/j.physbeh.2017.02.033
PG 5
WC Psychology, Biological; Behavioral Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Behavioral Sciences
GA FD4YP
UT WOS:000407538400002
PM 28257934
DA 2025-06-11
ER

PT J
AU Ferré, P
   Foufelle, F
AF Ferre, P.
   Foufelle, F.
TI Hepatic steatosis: a role for de novo lipogenesis and the
   transcription factor SREBP-1c
SO DIABETES OBESITY & METABOLISM
LA English
DT Review
DE endoplasmic reticulum stress; insulin resistance; lipogenesis; steatosis
ID ENDOPLASMIC-RETICULUM STRESS; ELEMENT-BINDING PROTEIN-1C; FATTY
   LIVER-DISEASE; INSULIN-RECEPTOR SUBSTRATE-1; X-RECEPTOR; ER STRESS;
   RAT-LIVER; SIGNALING PATHWAY; LIPID-METABOLISM; GENE-EXPRESSION
AB Steatosis is an accumulation of triglycerides in the liver. Although an excessive availability of plasma fatty acids is an important determinant of steatosis, lipid synthesis from glucose (lipogenesis) is now also considered as an important contributing factor. Lipogenesis is an insulin- and glucose-dependent process that is under the control of specific transcription factors, sterol regulatory element binding protein 1c (SREBP-1c), activated by insulin and carbohydrate response element binding protein (ChREBP) activated by glucose. Insulin induces the maturation of SREBP-1c by a proteolytic mechanism initiated in the endoplasmic reticulum (ER). SREBP-1c in turn activates glycolytic gene expression, allowing glucose metabolism, and lipogenic genes in conjunction with ChREBP. Lipogenesis activation in the liver of obese markedly insulin-resistant steatotic rodents is then paradoxical. Recent data suggest that the activation of SREBP-1c and thus of lipogenesis is secondary in the steatotic liver to an ER stress. The ER stress activates the cleavage of SREBP-1c independent of insulin, thus explaining the paradoxical stimulation of lipogenesis in an insulin-resistant liver. Inhibition of the ER stress in obese rodents decreases SREBP-1c activation and lipogenesis and improves markedly hepatic steatosis and insulin sensitivity. ER is thus a new partner in steatosis and metabolic syndrome which is worth considering as a potential therapeutic target.
C1 [Foufelle, F.] INSERM, Ctr Rech Cordeliers, UMR5 872, F-75006 Paris, France.
   Univ Paris 06, Paris, France.
C3 Sorbonne Universite; Institut National de la Sante et de la Recherche
   Medicale (Inserm); Universite Paris Cite; Sorbonne Universite
RP Foufelle, F (corresponding author), INSERM, Ctr Rech Cordeliers, UMR5 872, 15 Rue Ecole Med, F-75006 Paris, France.
EM fabienne.foufelle@crc.jussieu.fr
RI ; Ferre, Pascal/K-1250-2013
OI FOUFELLE, Fabienne/0000-0002-0752-622X; Ferre,
   Pascal/0000-0003-0115-7045
FU INSERM; Agence Nationale de la Recherche [ANR-2005-PCOD-035]; EXGENESIS
   European Commission [LSHM-CT-2004-005272, 241913]; Alfediam Takeda
FX The authors are supported by grants from INSERM, from the Agence
   Nationale de la Recherche (ANR-2005-PCOD-035), from the EXGENESIS
   European Commission Integrated Project Grant LSHM-CT-2004-005272, from
   the European Commission's Seventh Framework programme under grant
   agreement No. 241913 (FLORINASH) and from Alfediam Takeda.
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NR 89
TC 557
Z9 611
U1 2
U2 113
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1462-8902
J9 DIABETES OBES METAB
JI Diabetes Obes. Metab.
PD OCT
PY 2010
VL 12
SU 2
BP 83
EP 92
DI 10.1111/j.1463-1326.2010.01275.x
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 656XT
UT WOS:000282375100012
PM 21029304
DA 2025-06-11
ER

PT J
AU Nishida, M
   Kumagai, Y
   Ihara, H
   Fujii, S
   Motohashi, H
   Akaike, T
AF Nishida, Motohiro
   Kumagai, Yoshito
   Ihara, Hideshi
   Fujii, Shigemoto
   Motohashi, Hozumi
   Akaike, Takaaki
TI Redox signaling regulated by electrophiles and reactive sulfur species
SO JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION
LA English
DT Review
DE electrophilic signaling; 8-nitro-cGMP; NO; redox signaling; ROS
   signaling
ID NITRATED CYCLIC-GMP; NITRIC-OXIDE SYNTHASE; PROTEIN S-GUANYLATION;
   HYDROGEN-SULFIDE; KEAP1-NRF2 PATHWAY; OXIDATIVE STRESS; CHEMICAL
   BIOLOGY; NADPH OXIDASES; NRF2; METHYLMERCURY
AB Redox signaling is a key modulator of oxidative stress induced by nonspecific insults of biological molecules generated by reactive oxygen species. Current redox biology is revisiting the traditional concept of oxidative stress, such that toxic effects of reactive oxygen species are protected by diverse antioxidant systems upregulated by oxidative stress responses that are physiologically mediated by redox-dependent cell signaling pathways. Redox signaling is thus precisely regulated by endogenous electrophilic substances that are generated from reactive oxygen species and nitric oxide and its derivative reactive species during stress responses. Among electrophiles formed endogenously, 8-nitroguanosine 3',5'-cyclic monophosphate (8-nitro-cGMP) has unique cell signaling functions, and pathways for its biosynthesis, signaling mechanism, and metabolism in cells have been clarified. Reactive sulfur species such as cysteine hydropersulfides that are abundant in cells are likely involved in 8-nitro-cGMP metabolism. These new aspects of redox biology may stimulate innovative and multidisciplinary research in cell and stem cell biology; infectious diseases, cancer, metabolic syndrome, ageing, and neurodegenerative diseases; and other oxidative stress-related disorders. This review focuses on the most recent progress in the biosynthesis, cell signaling, and metabolism of 8-nitro-cGMP, which is a likely target for drug development and lead to discovery of novel therapeutics for many diseases.
C1 [Nishida, Motohiro] Natl Inst Nat Sci, Natl Inst Physiol Sci, Okazaki Inst Integrat Biosci, Div Cardiocirculatory Signaling, 5-1 Higashiyama,Myodaiji Cho, Okazaki, Aichi 4448787, Japan.
   [Nishida, Motohiro] Kyushu Univ, Grad Sch Pharmaceut Sci, Dept Translat Pharmaceut Sci, Higashi Ku, 3-1-1 Maidashi, Fukuoka 8128582, Japan.
   [Nishida, Motohiro] Japan Sci & Technol Agcy JST, PRESTO, 4-1-8 Honcho, Kawaguchi, Saitama 3320012, Japan.
   [Kumagai, Yoshito] Univ Tsukuba, Environm Biol Sect, Fac Med, 1-1-1 Tennodai, Tsukuba, Ibaraki 3058575, Japan.
   [Ihara, Hideshi] Osaka Prefecture Univ, Grad Sch Sci, Dept Biol Sci, Naka Ku, 1-1 Gakuen Cho, Sakai, Osaka 5998531, Japan.
   [Fujii, Shigemoto; Akaike, Takaaki] Tohoku Univ, Dept Environm Hlth Sci & Mol Toxicol, Grad Sch Med, Aoba Ku, 2-1 Seiryo Machi, Sendai, Miyagi 9808575, Japan.
   [Motohashi, Hozumi] Tohoku Univ, Inst Dev Aging & Canc, Dept Gene Express Regulat, Aoba Ku, 4-1 Seiryo Machi, Sendai, Miyagi 9808575, Japan.
C3 National Institutes of Natural Sciences (NINS) - Japan; National
   Institute for Physiological Sciences (NIPS); Okazaki Institute for
   Integrative Bioscience (OIIB); Kyushu University; Japan Science &
   Technology Agency (JST); University of Tsukuba; Osaka Metropolitan
   University; Tohoku University; Tohoku University
RP Akaike, T (corresponding author), Tohoku Univ, Dept Environm Hlth Sci & Mol Toxicol, Grad Sch Med, Aoba Ku, 2-1 Seiryo Machi, Sendai, Miyagi 9808575, Japan.
EM takaike@med.tohoku.ac.jp
RI Motohashi, Hozumi/AAZ-2628-2020
OI Nishida, Motohiro/0000-0002-2587-5458; Motohashi,
   Hozumi/0000-0002-7261-1033
FU PRESTO, Japan Science and Technology Agency; Ministry of Education,
   Culture, Sports, Science and Technology (MEXT), Japan; Ministry of
   Education, Culture, Sports, Science and Technology (MEXT);  [25293018]; 
   [25220103];  [25430069];  [15K08456];  [15H04692];  [25253020];
   Grants-in-Aid for Scientific Research [26111008, 25430069, 15H04692,
   26670207, 15K08456, 16K15228, 26111011] Funding Source: KAKEN
FX We thank J.B. Gandy for her excellent editing of the manuscript. We
   gratefully thank Profs. M. Yamamoto, K. Uchida, and T. Sawa, and other
   Principal Investigators who were responsible for the 12 research areas
   of the program project entitled "Signaling Functions of Reactive Oxygen
   Species," which was supported by Grants-in-Aid for Scientific Research
   on Innovative Areas (Research in a Proposed Research Area) from the
   Ministry of Education, Culture, Sports, Science and Technology (MEXT),
   Japan, from 2008 to 2012, for their invaluable discussions and
   collaboration. This work was supported in part by Grants-in-Aid for
   Scientific Research (B) to M.N. (No. 25293018), (S) to Y.K. (No.
   25220103), (C) to H.I. (No. 25430069), (C) to S.F. (No. 15K08456), (B)
   to H.M. (No. 15H04692), and (A) to T.A. (No. 25253020); by Grants-in-Aid
   for Scientific Research on Innovative Areas (Research in a Proposed
   Research Area) to T.A., H.M., M.N., H.I., and Y.K., from the Ministry of
   Education, Culture, Sports, Science and Technology (MEXT); and by
   PRESTO, Japan Science and Technology Agency.
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NR 66
TC 40
Z9 40
U1 0
U2 15
PU JOURNAL CLINICAL BIOCHEMISTRY & NUTRITION
PI KYOTO
PA KYOTO PREFECTURAL UNIV MED, GRAD SCH MEDICAL SCIENCE, DEPT MOLECULAR
   GASTROENTEROLOGY & HEPATOLOGY, KYOTO, 602-8566, JAPAN
SN 0912-0009
EI 1880-5086
J9 J CLIN BIOCHEM NUTR
JI J. Clin. Biochem. Nutr.
PD MAR 1
PY 2016
VL 58
IS 2
BP 91
EP 98
DI 10.3164/jcbn.15-111
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA DI8LJ
UT WOS:000373752200001
PM 27013774
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Jin, HM
   Zhou, DC
   Gu, HF
   Qiao, QY
   Fu, SK
   Liu, XL
   Pan, Y
AF Jin, Hui Min
   Zhou, Dong Chi
   Gu, Hui Fang
   Qiao, Qing Yan
   Fu, Shun Kun
   Liu, Xiao Li
   Pan, Yu
TI Antioxidant N-Acetylcysteine Protects Pancreatic β-Cells Against
   Aldosterone-Induced Oxidative Stress and Apoptosis in Female
   db/db Mice and Insulin-Producing MIN6 Cells
SO ENDOCRINOLOGY
LA English
DT Article
ID IN-VIVO; MINERALOCORTICOID RECEPTOR; METABOLIC SYNDROME; RENAL INJURY;
   RESISTANCE; SPIRONOLACTONE; RATS; HYPERTENSION; SECRETION; DYSFUNCTION
AB Previous studies have shown that primary aldosteronism is associated with glucose-related metabolic disorders. However, the mechanisms by which aldosterone (ALDO) triggers beta-cell dysfunction remains unclear. This study aimed to investigate whether oxidative stress is involved in and whether the antioxidant N-acetylcysteine (NAC) or the mineralocorticoid receptor antagonist spironolactone (SPL) could prevent or delay beta-cell damage in vivo and in vitro. As expected, 8 weeks after ALDO treatment, 12-week-old female diabetic db/db mice exhibited impaired oral glucose tolerance, decreased beta-cell mass, and heightened levels of oxidative stress marker (urinary 8-hydroxy-2'-deoxyguanosine). NAC reversed these symptoms completely, whereas SPL treatment did so only partially. After exposure to ALDO, the mouse pancreatic beta-cell line MIN6 exhibited decreased viability and increased caspase-3 activity, as well as reduced expression of Bcl-2/Bax and p-AKT, even if mineralocorticoid receptor was completely suppressed with small interfering RNA. NAC, but not SPL, suppressed oxidative stress in MIN6 cells, as revealed by the decrease in inducible NOS levels and expression of the proteins p22-phox and p67-phox. These findings suggest that oxidative stress may be involved in ALDO-induced beta-cell dysfunction and that NAC, but not SPL, may protect pancreatic beta-cells of mice from ALDO-induced oxidative stress and apoptosis in a manner independent of its receptor.
C1 [Jin, Hui Min; Zhou, Dong Chi; Gu, Hui Fang; Qiao, Qing Yan; Fu, Shun Kun] Fudan Univ, Shanghai Pudong Hosp, Pudong Med Ctr, Div Nephrol, Shanghai 201900, Peoples R China.
   [Liu, Xiao Li; Pan, Yu] Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 3, Div Nephrol, Sch Med, Shanghai 201900, Peoples R China.
C3 Fudan University; Shanghai Jiao Tong University
RP Pan, Y (corresponding author), Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 3, Div Nephrol, Sch Med, 280 Mo He Rd, Shanghai 201900, Peoples R China.
EM panyu1980@163.com
RI Liu, Xiaoli/AAB-5964-2022; Pan, Yu/N-3688-2013
OI Pan, Yu/0000-0001-9481-5240
FU Outstanding Leaders Training Program of the Pudong Health Bureau of
   Shanghai [PWRl2012-05]; Shanghai Committee on Science and Technology
   [08411962000]; Shanghai Municipal Education Commission [10YZ35];
   Shanghai Baoshan District Committee on Science and Technology [09-E-2]
FX This study was supported and funded by the Outstanding Leaders Training
   Program of the Pudong Health Bureau of Shanghai (Grant PWRl2012-05), by
   the Shanghai Committee on Science and Technology (Grant 08411962000), by
   the Shanghai Municipal Education Commission (Grant 10YZ35), and by the
   Shanghai Baoshan District Committee on Science and Technology (Grant
   09-E-2).
CR [Anonymous], 2004, COCHRANE DB SYST REV
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NR 38
TC 36
Z9 38
U1 0
U2 5
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0013-7227
EI 1945-7170
J9 ENDOCRINOLOGY
JI Endocrinology
PD NOV
PY 2013
VL 154
IS 11
BP 4068
EP 4077
DI 10.1210/en.2013-1115
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 238HI
UT WOS:000325935200018
PM 24008345
OA Bronze
DA 2025-06-11
ER

PT J
AU Machulsky, NF
   Colla, J
   Gonzalez, D
   Fortuna, F
   Ibar, C
   Jamardo, J
   Gagliardi, J
   Fabre, B
   Berg, G
AF Machulsky, Nahuel Fernandez
   Colla, Julian
   Gonzalez, Diego
   Fortuna, Federico
   Ibar, Carolina
   Jamardo, Juan
   Gagliardi, Juan
   Fabre, Bibiana
   Berg, Gabriela
TI Automated Chemiluminescent Hair Cortisol Measurement and Its Association
   with Acute Myocardial Infarction: A Case-Control Study in Latin American
   Adults
SO HEART AND MIND
LA English
DT Article
DE Acute myocardial infarction; automated method; hair cortisol; perceived
   stress; social support; triglycerides/high-density lipoprotein
   cholesterol index
ID ACUTE CORONARY SYNDROME; RISK-FACTORS; PSYCHOSOCIAL FACTORS;
   HEART-DISEASE; GLOBAL BURDEN; STRESS; INTERHEART; ADVERSITY; MORTALITY;
   HUMANS
AB Background: Chronic and psychosocial stresses are the emerging factors linked to cardiovascular disease. Assessment of cortisol levels in hair can serve as an indicator of an individual's exposure to prolonged stressful events. For its evaluation, mass spectrometry is the reference method. However, because of its limitations for clinical laboratories, an automated chemiluminescent method was developed in our laboratory. The objective of the study is to evaluate the hair cortisol levels measured by an automated method and its association with psychosocial stress and cardiometabolic risk factors in a Latin American population. Materials and Methods: Hair samples were obtained from 56 consecutive patients hospitalized with an ST-segment elevation acute myocardial infarction (STEMI) and 56 consecutive controls randomly recruited in routine consultation. Perceived stress and social support were evaluated by the validated questionnaires. Hair cortisol was measured by an automated chemiluminescent method. Glycemia and lipoprotein profile were measured in serum samples. Results: Hair cortisol was significantly higher in patients than in controls (175 [40-424] vs. 60.5 [40-155] pg of cortisol/mg of hair [P < 0.001]). Hair cortisol was not related to age or body mass index; however, it was related to glycemia (r = 0.461, P < 0.001) and triglycerides/high-density lipoprotein cholesterol (TGs/HDL-c) index (r = 0.398, P = 0.001). Perceived stress was related to hair cortisol (r = 0.425, P < 0.001), age (r = 0.321, P = 0.01), and social support (r = -0.208, P = 0.028). TGs/HDL-c index and perceived stress partially explain hair cortisol variation ([F = 8.69, P = 0.004] and [F = 24.9, P < 0.001], respectively). Conclusion: We observed higher hair cortisol concentrations, measured by an automated method, in STEMI patients than in controls in a Latin American population. In addition, it was related to perceived stress and cardiometabolic parameters.
C1 [Machulsky, Nahuel Fernandez; Gonzalez, Diego; Fortuna, Federico; Ibar, Carolina; Jamardo, Juan; Fabre, Bibiana; Berg, Gabriela] Univ Buenos Aires, Fac Farm & Bioquim, Dept Bioquim Clin, Catedra Bioquim Clin 1, Buenos Aires, Argentina.
   [Machulsky, Nahuel Fernandez; Gonzalez, Diego; Fortuna, Federico; Ibar, Carolina; Jamardo, Juan; Fabre, Bibiana; Berg, Gabriela] Univ Buenos Aires, Fac Farm & Bioquim, Inst Fisiopatol & Bioquim Clin, Buenos Aires, Argentina.
   [Colla, Julian; Gagliardi, Juan] Hosp Gen Dr Cosme Argerich, Div Cardiol, Unidad Hemodinamia, Buenos Aires, Argentina.
   [Berg, Gabriela] Univ Buenos Aires, Fac Farm & Bioquim, CONICET, Buenos Aires, Argentina.
C3 University of Buenos Aires; University of Buenos Aires; Consejo Nacional
   de Investigaciones Cientificas y Tecnicas (CONICET); University of
   Buenos Aires
RP Berg, G (corresponding author), Junin 956, RA-C1113AAD Buenos Aires, Argentina.
EM gaberg@ffyb.uba.ar
FU Universidad de Buenos Aires, Argentina (UBACYT) [20020150100033BA];
   Agencia Nacional de Promocion Cientifica y Tecnologica (ANPCYT) [PICT
   2016-0920, PICT 2019-0930]
FX This work was supported by a grant from the Universidad de Buenos Aires,
   Argentina (UBACYT: 20020150100033BA; 2020-2023) and from the Agencia
   Nacional de Promocion Cientifica y Tecnologica (ANPCYT) PICT 2016-0920
   and PICT 2019-0930.
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NR 53
TC 0
Z9 0
U1 0
U2 0
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, Maharashtra, INDIA
SN 2468-6476
EI 2468-6484
J9 HEART MIND
JI Heart Mind
PD JAN-FEB
PY 2025
VL 9
IS 1
BP 13
EP 20
DI 10.4103/hm.HM-D-24-00099
PG 8
WC Cardiac & Cardiovascular Systems; Psychiatry
WE Emerging Sources Citation Index (ESCI)
SC Cardiovascular System & Cardiology; Psychiatry
GA Y2P0C
UT WOS:001430595600009
OA gold
DA 2025-06-11
ER

PT J
AU de Luxán-Delgado, B
   Caballero, B
   Potes, Y
   Rubio-González, A
   Rodríguez, I
   Gutiérrez-Rodríguez, J
   Solano, JJ
   Coto-Montes, A
AF de Luxan-Delgado, Beatriz
   Caballero, Beatriz
   Potes, Yaiza
   Rubio-Gonzalez, Adrian
   Rodriguez, Illan
   Gutierrez-Rodriguez, Jose
   Solano, Juan J.
   Coto-Montes, Ana
TI Melatonin administration decreases adipogenesis in the liver of ob/ob
   mice through autophagy modulation
SO JOURNAL OF PINEAL RESEARCH
LA English
DT Article
DE adipogenesis; autophagy; melatonin; obesity; oxidative stress
ID OXIDATIVE STRESS; INSULIN-RESISTANCE; PATHOPHYSIOLOGICAL IMPLICATIONS;
   DROSOPHILA-MELANOGASTER; ANTIOXIDANT ENZYMES; LIPID-PEROXIDATION;
   METABOLIC SYNDROME; INDUCED OBESITY; OXIDANT STRESS; WEIGHT-GAIN
AB Despite efforts to curb the incidence of obesity and its comorbidities, this condition remains the fifth leading cause of death worldwide. To identify ways to reduce this global effect, we investigated the actions of daily melatonin administration on oxidative stress parameters and autophagic processes as a possible treatment of obesity in ob/ob mice. The involvement of melatonin in many physiological functions, such as the regulation of seasonal body weight variation, glucose uptake, or adiposity, and the role of this indoleamine as an essential antioxidant, has become the focus of numerous anti-obesity studies. Here, we examined the oxidative status in the livers of obese melatonin-treated and untreated mice, observing a decrease in the oxidative stress levels through elevated catalase activity. ROS-mediated autophagy was downregulated in the liver of melatonin-treated animals and was accompanied by significant accumulation of p62. Autophagy is closely associated with adipogenesis; in this study, we report that melatonin-treated obese mice also showed reduced adiposity, as demonstrated by diminished body weight and reduced peroxisome proliferator-activated receptor gamma expression. Based on these factors, it is reasonable to assume that oxidative stress and autophagy play important roles in obesity, and therefore, melatonin could be an interesting target molecule for the development of a potential therapeutic agent to curb body weight.
C1 [de Luxan-Delgado, Beatriz; Caballero, Beatriz; Potes, Yaiza; Rubio-Gonzalez, Adrian; Rodriguez, Illan; Coto-Montes, Ana] Univ Oviedo, Dept Morphol & Cellular Biol, Fac Med, E-33006 Oviedo, Spain.
   [Gutierrez-Rodriguez, Jose; Solano, Juan J.] Monte Naranco Hosp, Geriatr Serv, Oviedo, Spain.
C3 University of Oviedo
RP de Luxán-Delgado, B (corresponding author), Univ Oviedo, Dept Morphol & Cellular Biol, Fac Med, C Julian Claveria S-N, E-33006 Oviedo, Spain.
EM b.luxandelgado@gmail.com; acoto@uniovi.es
RI Luxán-Delgado, Beatriz/AAC-8452-2020; Caballero García,
   Beatriz/AAC-2636-2020; Solano, Juan/M-6191-2013; Potes,
   Yaiza/AAU-2188-2021; COTO-MONTES, ANA/D-2544-2016
OI Rubio-Gonzalez, Adrian/0000-0002-1458-2115; COTO-MONTES,
   ANA/0000-0002-6609-6258; Luxan-Delgado, Beatriz/0000-0003-4507-716X;
   Potes, Yaiza/0000-0002-4687-6230; Caballero Garcia,
   Beatriz/0000-0003-0242-9620
FU FEDER funds; University of Oviedo;  [FISS-06-RD06/0013/0011]; 
   [FISS-06-RD06/0013/0028];  [BFU2010-20919]
FX We thank to Dr. de Gonzalo-Calvo and Mme. Garcia-Macia for helping in
   study design and Mr. de Luxan-Melendez for assistant in developing
   figures. We are members of the INPROTEOLYS and INEUROPA network. This
   work was supported by: FISS-06-RD06/0013/0011 and
   FISS-06-RD06/0013/0028; BFU2010-20919 and FEDER funds. B. de L-D is
   FICYT pre-doctoral fellow from the Gobierno del Principado de Asturias.
   Financial support from the University of Oviedo is also acknowledged.
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NR 73
TC 21
Z9 21
U1 1
U2 21
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0742-3098
EI 1600-079X
J9 J PINEAL RES
JI J. Pineal Res.
PD MAR
PY 2014
VL 56
IS 2
BP 126
EP 133
DI 10.1111/jpi.12104
PG 8
WC Endocrinology & Metabolism; Neurosciences; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Physiology
GA AA8TI
UT WOS:000331367500002
PM 24134701
DA 2025-06-11
ER

PT J
AU Teixeira, LG
   Lages, PC
   Jascolka, TL
   Aguilar, EC
   Soares, FLP
   Pereira, SS
   Beltrao, NRM
   Matoso, RD
   do Nascimento, AM
   de Castilho, RO
   Leite, JIA
AF Teixeira, Lilian Goncalves
   Lages, Priscilla Ceci
   Jascolka, Tatianna Lemos
   Aguilar, Edenil Costa
   Pires Soares, Fabiola Lacerda
   Pereira, Solange Silveira
   Mota Beltrao, Nathalia Ribeiro
   Matoso, Rafael de Oliveira
   do Nascimento, Andre Marcio
   de Castilho, Rachel Oliveira
   Alvarez Leite, Jacqueline Isaura
TI White tea (Camellia sinensis) extract reduces oxidative stress
   and triacylglycerols in obese mice
SO CIENCIA E TECNOLOGIA DE ALIMENTOS
LA English
DT Article
DE high-fat diet; obesity; oxidative stress; white tea; Camellia sinensis
ID GREEN TEA; METABOLIC SYNDROME; ADIPOSE-TISSUE; INSULIN-RESISTANCE;
   HYDROGEN-PEROXIDE; FAT OXIDATION; ANTIOXIDANT; CATECHINS; RAT;
   LIPOPROTEIN
AB White tea is an unfermented tea made from young shoots of Camellia sinensis protected from sunlight to avoid polyphenol degradation. Although its levels of catechins are higher than those of green tea (derived from the same plant), there are no studies addressing the relationship between this tea and obesity associated with oxidative stress. The objective of this study was to evaluate the effect of white tea on obesity and its complications using a diet induced obesity model. Forty male C57BL/6 mice were fed a high-fat diet to induce obesity (Obese group) or the same diet supplemented with 0.5% white tea extract (Obese + WTE) for 8 weeks. Adipose tissue, serum lipid profile, and oxidative stress were studied. White tea supplementation was not able to reduce food intake, body weight, or visceral adiposity. Similarly, there were no changes in cholesterol rich lipoprotein profile between the groups. A reduction in blood triacylglycerols associated with increased cecal lipids was observed in the group fed the diet supplemented with white tea. White tea supplementation also reduced oxidative stress in liver and adipose tissue. In conclusion, white tea extract supplementation (0.5%) does not influence body weight or adiposity in obese mice. Its benefits are restricted to the reduction in oxidative stress associated with obesity and improvement of hypertriacylglycerolemia.
C1 [Teixeira, Lilian Goncalves; Lages, Priscilla Ceci; Aguilar, Edenil Costa; Mota Beltrao, Nathalia Ribeiro; Matoso, Rafael de Oliveira; Alvarez Leite, Jacqueline Isaura] Univ Fed Minas Gerais, Inst Biol Sci, Dept Biochem & Immunol, BR-30161970 Belo Horizonte, MG, Brazil.
   [Jascolka, Tatianna Lemos; Pires Soares, Fabiola Lacerda; Pereira, Solange Silveira; do Nascimento, Andre Marcio; de Castilho, Rachel Oliveira] Univ Fed Minas Gerais, Fac Pharm, BR-30161970 Belo Horizonte, MG, Brazil.
C3 Universidade Federal de Minas Gerais; Universidade Federal de Minas
   Gerais
RP Teixeira, LG (corresponding author), Univ Fed Minas Gerais, Inst Biol Sci, Dept Biochem & Immunol, Av Antonio Carlos 6627, BR-30161970 Belo Horizonte, MG, Brazil.
EM lilianteixeiranutricao@gmail.com
RI Teixeira, Lílian/CAI-1620-2022; ALVAREZ-LEITE, JACQUELINE/C-9175-2014
OI S. Pereira, Solange/0000-0002-3146-6992
FU FAPEMIG
FX The authors are grateful to Maria Helena Alves Oliveira for the animal
   care assistance and to the Galgani Pharmacy for supplying white tea
   extract. CAPES (Coordination of Personal Improvement of Higher
   Education), CNPq (National Counsel of Technological and Scientific
   Development) and FAPEMIG (Foundation for Research Support of Minas
   Gerais).
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NR 56
TC 18
Z9 20
U1 0
U2 39
PU SOC BRASILEIRA CIENCIA TECNOLOGIA ALIMENTOS
PI CAMPINAS
PA AV BRASIL 2880, CAXIA POSTAL 271 CEP 13001-970, CAMPINAS, SAO PAULO
   00000, BRAZIL
SN 0101-2061
EI 1678-457X
J9 CIENCIA TECNOL ALIME
JI Ciencia Tecnol. Aliment.
PD OCT-DEC
PY 2012
VL 32
IS 4
BP 733
EP 741
DI 10.1590/S0101-20612012005000099
PG 9
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA 058YN
UT WOS:000312671300015
OA gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Choromanska, B
   Mysliwiec, P
   Luba, M
   Wojskowicz, P
   Mysliwiec, H
   Choromanska, K
   Dadan, J
   Zendzian-Piotrowska, M
   Zalewska, A
   Maciejczyk, M
AF Choromanska, Barbara
   Mysliwiec, Piotr
   Luba, Magdalena
   Wojskowicz, Piotr
   Mysliwiec, Hanna
   Choromanska, Katarzyna
   Dadan, Jacek
   Zendzian-Piotrowska, Malgorzata
   Zalewska, Anna
   Maciejczyk, Mateusz
TI Bariatric Surgery Normalizes Protein Glycoxidation and Nitrosative
   Stress in Morbidly Obese Patients
SO ANTIOXIDANTS
LA English
DT Article
DE morbid obesity; bariatric surgery; protein glycoxidation; nitrosative
   stress
ID LAPAROSCOPIC SLEEVE GASTRECTOMY; Y GASTRIC BYPASS; NITRIC-OXIDE;
   INSULIN-RESISTANCE; S-NITROSOTHIOLS; END-PRODUCTS; AMINO-ACIDS;
   WEIGHT-LOSS; BIOAVAILABILITY; NITRATION
AB The results of recent studies indicate the key role of nitrosative stress and protein oxidative damage in the development of morbid obesity. Nevertheless, the effect of bariatric surgery on protein oxidation/glycation and nitrosative/nitrative stress is not yet known. This is the first study evaluating protein glycoxidation and protein nitrosative damage in morbidly obese patients before and after (one, three, six and twelve months) laparoscopic sleeve gastrectomy. The study included 50 women with morbid obesity as well as 50 age- and gender-matched healthy controls. We demonstrated significant increases in serum myeloperoxidase, plasma glycooxidative products (dityrosine, kynurenine, N-formyl-kynurenine, amyloid, Amadori products, glycophore), protein oxidative damage (ischemia modified albumin) and nitrosative/nitrative stress (nitric oxide, peroxy-nitrite, S-nitrosothiols and nitro-tyrosine) in morbidly obese subjects as compared to lean controls, whereas plasma tryptophan and total thiols were statistically decreased. Bariatric surgery generally reduces the abnormalities in the glycoxidation of proteins and nitrosative/nitrative stress. Noteworthily, in the patients with metabolic syndrome (MS+), we showed no differences in most redox biomarkers, as compared to morbidly obese patients without MS (MS-). However, two markers: were able to differentiate MS+ and MS- with high specificity and sensitivity: peroxy-nitrite (>70%) and S-nitrosothiols (>60%). Further studies are required to confirm the diagnostic usefulness of such biomarkers.
C1 [Choromanska, Barbara; Mysliwiec, Piotr; Luba, Magdalena; Wojskowicz, Piotr; Dadan, Jacek] Med Univ Bialystok, Dept Gen & Endocrine Surg, 24a M Sklodowskiej Curie St, PL-15276 Bialystok, Poland.
   [Mysliwiec, Hanna] Med Univ Bialystok, Dept Dermatol & Venereol, 14 Zurawia St, PL-15540 Bialystok, Poland.
   [Choromanska, Katarzyna] Med Univ Gdansk, Dept Oral Surg, 7 Debinki St, PL-80211 Gdansk, Poland.
   [Zendzian-Piotrowska, Malgorzata; Maciejczyk, Mateusz] Med Univ Bialystok, Dept Hyg Epidemiol & Ergon, 2c Mickiewicza St, PL-15233 Bialystok, Poland.
   [Zalewska, Anna] Med Univ Bialystok, Expt Dent Lab, 24a M Sklodowskiej Curie St, PL-15274 Bialystok, Poland.
C3 Medical University of Bialystok; Medical University of Bialystok;
   Fahrenheit Universities; Medical University Gdansk; Medical University
   of Bialystok; Medical University of Bialystok
RP Choromanska, B (corresponding author), Med Univ Bialystok, Dept Gen & Endocrine Surg, 24a M Sklodowskiej Curie St, PL-15276 Bialystok, Poland.; Maciejczyk, M (corresponding author), Med Univ Bialystok, Dept Hyg Epidemiol & Ergon, 2c Mickiewicza St, PL-15233 Bialystok, Poland.
EM barbara.choromanska@umb.edu.pl; piotr.a.mysliwiec@gmail.com;
   ananau@wp.pl; pwojsk@wp.pl; hanna.mysliwiec@gmail.com; kasia24_89@o2.pl;
   jacdad@poczta.onet.pl; mzpiotrowska@gmail.com; azalewska426@gmail.com;
   mat.maciejczyk@gmail.com
RI Myśliwiec, Hanna/S-6326-2018; Zalewska, Anna/AAG-9484-2019;
   Żendzian-Piotrowska, Małgorzata/G-4481-2011; Myśliwiec,
   Piotr/T-4220-2018; Zendzian-Piotrowska, Malgorzata/S-6354-2018;
   Maciejczyk, Mateusz/R-6568-2018
OI Zalewska, Anna/0000-0003-4562-0951; Zendzian-Piotrowska,
   Malgorzata/0000-0002-4350-0369; Maciejczyk, Mateusz/0000-0001-5609-3187;
   Dadan, Jacek/0000-0002-0691-9785
FU Medical University of Bialystok, Poland [SUB/1/DN/20/002/1209,
   SUB/1/DN/20/002/3330, SUB/1/DN/20/001/1140]; Foundation for Polish
   Science (FNP)
FX This work was granted by the Medical University of Bialystok, Poland
   (grant numbers: SUB/1/DN/20/002/1209; SUB/1/DN/20/002/3330;
   SUB/1/DN/20/001/1140); Mateusz Maciejczyk was supported by the
   Foundation for Polish Science (FNP).
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NR 64
TC 23
Z9 23
U1 0
U2 0
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD NOV
PY 2020
VL 9
IS 11
AR 1087
DI 10.3390/antiox9111087
PG 18
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA OX5ZG
UT WOS:000593641800001
PM 33158288
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Peix, A
   Trápaga, A
   Asen, L
   Ponce, F
   Infante, O
   Valiente, J
   Tornés, F
   Cabrera, LO
   Guerrero, I
   García, EJ
   Carrillo, R
   García-Barreto, D
AF Peix, Amalia
   Trapaga, Angelina
   Asen, Lucrecia
   Ponce, Felizardo
   Infante, Olga
   Valiente, Juan
   Tornes, Francisco
   Cabrera, Lazaro O.
   Guerrero, Israel
   Garcia, Ernesto J.
   Carrillo, Regla
   Garcia-Barreto, David
TI Mental stress-induced myocardial ischemia in women with angina and
   normal coronary angiograms
SO JOURNAL OF NUCLEAR CARDIOLOGY
LA English
DT Article
DE mental stress; women; myocardial scintigraphy; angina; normal coronary
   angiogram
ID CARDIAC SYNDROME-X; VENTRICULAR EJECTION FRACTION; BLOOD-FLOW RESPONSE;
   ARTERY-DISEASE; ENDOTHELIAL DYSFUNCTION; PERFUSION DEFECTS;
   RISK-FACTORS; CHEST-PAIN; EXERCISE; ATHEROSCLEROSIS
AB Background. Coronary artery disease is frequent in postmenopausal women. Silent myocardial ischemia has been induced with mental stress testing.
   Methods and Results. To evaluate whether mental stress can induce ischemia in women with typical angina and normal coronary angiography, postmenopausal patients (n = 16) were studied. Each underwent technetium 99m methoxyisobutylisonitrile myocardial scintigraphy (exercise stress/rest/mental stress protocol), brachial artery endothelial function measurement by ultrasonography, and 24-hour ambulatory electrocardiographic recording (Holter). During mental stress testing, 6 patients (group 1) had reversible perfusion defects on myocardial scintigraphy whereas the other 10 patients (group 11) did not. Group I patients exhibited endothelial dysfunction more frequently than those in group 11 (83% vs 20%). Myocardial scintigraphy showed anteroapical/septal ischemia in 5 patients and inferoapical ischemia in one other patient, with both types of stress. Among group 11 patients, none showed a reversible perfusion defect during physical or mental stress. No group I patients had evidence of ischemia by Holter monitoring, whereas 2 of 10 group 11 patients did.
   Conclusion. In postmenopausal women with typical angina and normal coronary arteries, mental stress may provoke myocardial ischemia, which can be concordant with ischemia induced by exercise stress, and is associated with endothelial dysfunction.
C1 Inst Cardiol, Dept Nucl Med, Havana 10400, Cuba.
   Dept Psychol, Havana, Cuba.
RP Peix, A (corresponding author), Inst Cardiol, Dept Nucl Med, 17 702,Vedado, Havana 10400, Cuba.
EM peix@infomed.sld.cu
RI Ponce, Fernando/M-8649-2013
CR Arrighi JA, 2000, LANCET, V356, P310, DOI 10.1016/S0140-6736(00)02510-1
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NR 30
TC 26
Z9 32
U1 1
U2 1
PU MOSBY, INC
PI ST LOUIS
PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 USA
SN 1071-3581
J9 J NUCL CARDIOL
JI J. Nucl. Cardiol.
PD JUL-AUG
PY 2006
VL 13
IS 4
BP 507
EP 513
DI 10.1016/j.nuclcard.2006.03.016
PG 7
WC Cardiac & Cardiovascular Systems; Radiology, Nuclear Medicine & Medical
   Imaging
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Radiology, Nuclear Medicine &
   Medical Imaging
GA 073IR
UT WOS:000239736700009
PM 16919574
DA 2025-06-11
ER

PT J
AU Deledda, A
   Annunziata, G
   Tenore, GC
   Palmas, V
   Manzin, A
   Velluzzi, F
AF Deledda, Andrea
   Annunziata, Giuseppe
   Tenore, Gian Carlo
   Palmas, Vanessa
   Manzin, Aldo
   Velluzzi, Fernanda
TI Diet-Derived Antioxidants and Their Role in Inflammation, Obesity and
   Gut Microbiota Modulation
SO ANTIOXIDANTS
LA English
DT Review
DE inflammation; obesity; gut microbiota; oxidative stress; antioxidants;
   polyphenols; ageing; nutraceutical
ID FACTOR-KAPPA-B; GLYCATION END-PRODUCTS; GREEN TEA POLYPHENOL; OXIDATIVE
   STRESS; MEDITERRANEAN DIET; METABOLIC SYNDROME; GENE-EXPRESSION; CAUSAL
   ROLE; CELL-LINE; RESVERATROL
AB It is generally accepted that gut microbiota, inflammation and obesity are linked to the development of cardiovascular diseases and other chronic/non-communicable pathological conditions, including cancer, neurodegenerative diseases and ageing-related disorders. In this scenario, oxidative stress plays a pivotal role. Evidence suggests that the global dietary patterns may represent a tool in counteracting oxidative stress, thus preventing the onset of diseases related to oxidative stress. More specifically, dietary patterns based on the regular consumption of fruits and vegetables (i.e., Mediterranean diet) have been licensed by various national nutritional guidelines in many countries for their health-promoting effects. Such patterns, indeed, result in being rich in specific components, such as fiber, minerals, vitamins and antioxidants, whose beneficial effects on human health have been widely reported. This suggests a potential nutraceutical power of specific dietary components. In this manuscript, we summarize the most relevant evidence reporting the impact of dietary antioxidants on gut microbiota composition, inflammation and obesity, and we underline that antioxidants are implicated in a complex interplay between gut microbiota, inflammation and obesity, thus suggesting their possible role in the development and modulation of chronic diseases related to oxidative stress and in the maintenance of wellness. Do all roads lead to Rome?
C1 [Deledda, Andrea; Velluzzi, Fernanda] Univ Cagliari, Osped San Giovanni di Dio, Dept Med Sci & Publ Hlth, Obes Unit, Via Osped 54, I-09124 Cagliari, Italy.
   [Annunziata, Giuseppe; Tenore, Gian Carlo] Univ Naples Federico II, Dept Pharm, Via Domenico Montesano 49, I-80131 Naples, Italy.
   [Palmas, Vanessa; Manzin, Aldo] Univ Cagliari, Dept Biomed Sci, Microbiol & Virol Unit, I-09042 Monserrato, Italy.
C3 University of Cagliari; University of Naples Federico II; University of
   Cagliari
RP Annunziata, G (corresponding author), Univ Naples Federico II, Dept Pharm, Via Domenico Montesano 49, I-80131 Naples, Italy.
EM andredele@tiscali.it; giuseppe.annunziata@unina.it;
   giancarlo.tenore@unina.it; vanessapalmas@hotmail.it;
   aldomanzin@unica.it; fernandavelluzzi@gmail.com
RI Annunziata, Giuseppe/W-2529-2019; Deledda, Andrea/ABG-8420-2021; Manzin,
   Aldo/F-9450-2011
OI Palmas, Vanessa/0009-0001-8961-2198; Deledda,
   Andrea/0000-0001-6925-7515; Annunziata, Giuseppe/0000-0002-1922-662X;
   Tenore, Gian Carlo/0000-0002-0251-9936; Manzin, Aldo/0000-0003-2961-3428
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NR 186
TC 87
Z9 89
U1 8
U2 57
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD MAY
PY 2021
VL 10
IS 5
AR 708
DI 10.3390/antiox10050708
PG 22
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA SG3QQ
UT WOS:000653356800001
PM 33946864
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Segura-Garcia, C
   Caroleo, M
   Rania, M
   Barbuto, E
   Sinopoli, F
   Aloi, M
   Arturi, F
   De Fazio, P
AF Segura-Garcia, Cristina
   Caroleo, Mariarita
   Rania, Marianna
   Barbuto, Elvira
   Sinopoli, Flora
   Aloi, Matteo
   Arturi, Franco
   De Fazio, Pasquale
TI Binge Eating Disorder and Bipolar Spectrum disorders in obesity:
   Psychopathological and eating behaviors differences according to
   comorbidities
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Obesity; Comorbidity; Binge eating disorder; Bipolar Spectrum Disorders;
   Eating behavior
ID PSYCHIATRIC-DISORDERS; METABOLIC SYNDROME; SCHIZOPHRENIA; TEMPERAMENT;
   PREVALENCE; ASSOCIATION; OVERWEIGHT; INVENTORY; CHARACTER; FEATURES
AB Background: Obesity is not a mental disorder, yet DSM-5 recognizes a strong association between obesity and psychiatric syndromes. Disorders within the Bipolar Spectrum (BSD) and Binge Eating Disorder (BED) are the most frequent psychiatric disorders among obese patients. The aim of this research is to investigate the psychopathological differences and the distinctive eating behaviors that accompany these comorbidities in obese patients.
   Methods: One hundred and nineteen obese patients (40 males; 79 females) underwent psychological evaluation and psychiatric interview, and a dietitian evaluated their eating habits. Patients were divided into four groups according to comorbidities, and comparisons were run accordingly.
   Results: Forty-one percent of participants presented BED+BSD comorbidity (Group 1), 21% BED (Group 2) and 8% BSD (Group 3); only 29% obese participants had no comorbidity (Group 4). Female gender was overrepresented among Groups 1 and 2. BSD diagnosis varied according to comorbidities: Type II Bipolar Disorder and Other Specified and Related Bipolar Disorder (OSR BD) were more frequent in Group 1 and Type I Bipolar Disorder in Group 3. A trend of decreasing severity in eating behaviors and psychopathology was evident according to comorbidities (Group 1=Group2 > Group3 > Group 4).
   Limitations: Limitations include the small sample size and the cross-sectional design of the study.
   Conclusions: BED and BSD are frequent comorbidities in obesity. Type II Bipolar Disorder and OSR BD are more frequent in the group with double comorbidity. The double comorbidity seems associated to more severe eating behaviors and psychopathology. Distinctive pathological eating behaviors could be considered as warning signals, symptomatic of psychiatric comorbidities in Obesity.
C1 [Segura-Garcia, Cristina; Caroleo, Mariarita; Rania, Marianna; Barbuto, Elvira; Aloi, Matteo; De Fazio, Pasquale] Magna Graecia Univ Catanzaro, Dept Hlth Sci, Catanzaro, Italy.
   [Sinopoli, Flora] Univ Hosp Mater Domini, Dietet Serv, Catanzaro, Italy.
   [Arturi, Franco] Magna Graecia Univ Catanzaro, Dept Med & Surg Sci, Catanzaro, Italy.
C3 Magna Graecia University of Catanzaro; Magna Graecia University of
   Catanzaro
RP Segura-Garcia, C (corresponding author), Magna Graecia Univ Catanzaro, Dept Hlth Sci, Catanzaro, Italy.
EM segura@unicz.it
RI Aloi, Matteo/AAP-6283-2020; Rania, Marianna/AAB-7378-2022;
   Segura-Garcia, Cristina/I-8978-2014
OI Caroleo, Mariarita/0000-0001-5856-5344; rania,
   marianna/0000-0001-7742-7086; DE FAZIO, PASQUALE/0000-0001-5375-3565;
   Aloi, Matteo/0000-0001-5585-6488; Segura-Garcia,
   Cristina/0000-0002-5756-3045
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NR 62
TC 24
Z9 24
U1 1
U2 36
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD JAN 15
PY 2017
VL 208
BP 424
EP 430
DI 10.1016/j.jad.2016.11.005
PG 7
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA EG0OR
UT WOS:000390732600061
PM 27846411
DA 2025-06-11
ER

PT J
AU Kandeil, MA
   Hashem, RM
   Mahmoud, MO
   Hetta, MH
   Tohamy, MA
AF Kandeil, Mohamed A.
   Hashem, Reem M.
   Mahmoud, Mohamed O.
   Hetta, Mona H.
   Tohamy, Mohamed A.
TI Zingiber officinale extract and omega-3 fatty acids ameliorate
   endoplasmic reticulum stress in a nonalcoholic fatty liver rat model
SO JOURNAL OF FOOD BIOCHEMISTRY
LA English
DT Article
DE ER stress; high-fat diet; NAFLD; omega-3; steatosis; Zingiber officinale
ID HEPATIC STEATOSIS; METABOLIC SYNDROME; ETHANOLIC EXTRACT; GENES
AB Endoplasmic reticulum (ER) stress was reported to play a major role in non-alcoholic fatty liver disease (NAFLD) induction and progression. Here, we study the effect of Zingiber officinale and omega-3 fatty acids on ER stress for treating NAFLD. Male Wistar rats were fed on a normal diet (control group) or high-fat diet (HFD) for 8 weeks. The HFD rats were later treated with vehicle, omega-3 or with Z. officinale extract. HFD group demonstrated significantly more body weight gain and higher plasma lipid profile, glucose, and hepatic enzymes. The expressions of lipogenic ChREBP and ER stress genes CHOP, XBP1, and GRP78 were increased. This was accompanied by intrahepatic fat accumulation visualized by hepatic morphology and H&E-stained sections. Treatment with Z. officinale and omega-3 fatty acids reverted these changes into a normal healthy state. From these results, we prove that both therapeutic approaches can be potential drugs for treating NAFLD besides other ER stress-associated diseases. Practical applications The effect of Zingiber officinale extract and omega-3 fatty acid on ER stress associated with NAFLD was investigated. The results revealed that Z. officinale extract and omega-3 fatty acids significantly inhibited ER stress and intrahepatic fat accumulation with the upper hand for Z. officinale extract. Both can be used as future promising therapies for the treatment of NAFLD patients and also treating different diseases that involve ER stress as a pathological modulator like diabetes mellitus, Alzheimer's disease, Parkinson's disease, and cancer.
C1 [Kandeil, Mohamed A.] Beni Suef Univ, Dept Biochem, Fac Vet Med, Bani Suwayf 62511, Egypt.
   [Hashem, Reem M.; Mahmoud, Mohamed O.; Tohamy, Mohamed A.] Beni Suef Univ, Dept Biochem, Fac Pharm, Bani Suwayf 62514, Egypt.
   [Hetta, Mona H.] Fayoum Univ, Dept Pharmacognosy, Fac Pharm, Al Fayyum 63514, Egypt.
   [Tohamy, Mohamed A.] Univ Michigan, Dept Mol & Integrat Physiol, Ann Arbor, MI 48109 USA.
C3 Egyptian Knowledge Bank (EKB); Beni Suef University; Egyptian Knowledge
   Bank (EKB); Beni Suef University; Egyptian Knowledge Bank (EKB); Fayoum
   University; University of Michigan System; University of Michigan
RP Tohamy, MA (corresponding author), Beni Suef Univ, Dept Biochem, Fac Pharm, Bani Suwayf 62514, Egypt.
EM mtohamy@med.umich.edu
RI Hetta, Mona/AAR-8274-2021
OI Mahmoud, Mohamed/0000-0002-6737-8142; kandeal,
   mohamed/0000-0003-4993-4042; Tohamy, Mohamed/0000-0002-5232-4766
FU Support and Project Finance Office, Scientific Research Developing Unit,
   Beni-Suef University, Beni-Suef, Egypt [YRP32, 2016/2017]
FX This work was supported by the Support and Project Finance Office,
   Scientific Research Developing Unit, Beni-Suef University, Beni-Suef,
   Egypt [grant numbers YRP32, 2016/2017, Grant holder (PI): Mohamed A.
   Tohamy]
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NR 36
TC 16
Z9 16
U1 1
U2 28
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0145-8884
EI 1745-4514
J9 J FOOD BIOCHEM
JI J. Food Biochem.
PD DEC
PY 2019
VL 43
IS 12
AR e13076
DI 10.1111/jfbc.13076
EA OCT 2019
PG 9
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA LB1IL
UT WOS:000490071800001
PM 31608477
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Schramm, A
   Matusik, P
   Osmenda, G
   Guzik, TJ
AF Schramm, Agata
   Matusik, Pawel
   Osmenda, Grzegorz
   Guzik, Tomasz J.
TI Targeting NADPH oxidases in vascular pharmacology
SO VASCULAR PHARMACOLOGY
LA English
DT Review
DE Superoxide; NADPH oxidase; Vascular; Endothelium; Oxidative stress
ID NITRIC-OXIDE SYNTHASE; IMPROVES ENDOTHELIAL FUNCTION; VITAMIN-E
   SUPPLEMENTATION; LOW-DENSITY-LIPOPROTEIN; EXTRACELLULAR-SUPEROXIDE
   DISMUTASE; CARDIOMETABOLIC RISK-FACTORS; RENIN-ANGIOTENSIN SYSTEM;
   INDUCED OXIDATIVE STRESS; CALCIUM-CHANNEL BLOCKER; II-INDUCED
   HYPERTENSION
AB Oxidative stress is a molecular dysregulation in reactive oxygen species (ROS) metabolism, which plays a key role in the pathogenesis of atherosclerosis, vascular inflammation and endothelial dysfunction. It is characterized by a loss of nitric oxide (NO) bioavailability. Large clinical trials such as HOPE and HPS have not shown a clinical benefit of antioxidant vitamin C or vitamin E treatment, putting into question the role of oxidative stress in cardiovascular disease. A change in the understanding of the molecular nature of oxidative stress has been driven by the results of these trials. Oxidative stress is no longer perceived as a simple imbalance between the production and scavenging of ROS, but as a dysfunction of enzymes involved in ROS production. NADPH oxidases are at the center of these events, underlying the dysfunction of other oxidases including eNOS uncoupling, xanthine oxidase and mitochondria! dysfunction. Thus NADPH oxidases are important therapeutic targets. Indeed, HMG-CoA reductase inhibitors (statins) as well as drugs interfering with the renin-angiotensin-aldosterone system inhibit NADPH oxidase activation and expression. Angiotensin-converting enzyme (ACE) inhibitors, AT1 receptor antagonists (sartans) and aliskiren, as well as spironolactone or eplerenone, have been discussed. Molecular aspects of NADPH oxidase regulation must be considered, while thinking about novel pharmacological targeting of this family of enzymes consisting of several homologs Nox1, Nox2, Nox3, Nox4 and Nox5 in humans.
   In order to properly design trials of antioxidant therapies, we must develop reliable techniques for the assessment of local and systemic oxidative stress. Classical antioxidants could be combined with novel oxidase inhibitors. In this review, we discuss NADPH oxidase inhibitors such as VAS2870, VAS3947, GK-136901, S17834 or plumbagin. Therefore, our efforts must focus on generating small molecular weight inhibitors of NADPH oxidases, allowing the selective inhibition of dysfunctional NADPH oxidase homologs. This appears to be the most reasonable approach, potentially much more efficient than non-selective scavenging of all ROS by the administration of antioxidants. (C) 2012 Elsevier Inc. All rights reserved.
C1 [Schramm, Agata; Matusik, Pawel; Osmenda, Grzegorz; Guzik, Tomasz J.] Jagiellonian Univ, Sch Med, Translat Med Lab, Dept Internal & Agr Med, PL-31121 Krakow, Poland.
C3 Jagiellonian University
RP Guzik, TJ (corresponding author), Jagiellonian Univ, Sch Med, J Dietl Hosp, Dept Internal & Agr Med, Ul Skarbowa 1, PL-31121 Krakow, Poland.
EM tguzik@cm-uj.krakow.pl
RI Guzik, Tomasz/AAM-5007-2020; Schramm-Luc, Agata/MFZ-7343-2025; Matusik,
   Paweł/I-7301-2012; Stefanadis, Christodoulos/ABH-2232-2020
OI Stefanadis, Christodoulos/0000-0001-5974-6454; Matusik,
   Pawel/0000-0001-5788-575X; Guzik, Tomasz/0000-0002-5039-7849
FU Wellcome Trust [090883] Funding Source: Medline
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NR 190
TC 181
Z9 198
U1 1
U2 48
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1537-1891
EI 1879-3649
J9 VASC PHARMACOL
JI Vasc. Pharmacol.
PD MAY-JUN
PY 2012
VL 56
IS 5-6
SI SI
BP 216
EP 231
DI 10.1016/j.vph.2012.02.012
PG 16
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 980JM
UT WOS:000306889400007
PM 22405985
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Myburgh, C
   Huisman, HW
   Mels, CMC
AF Myburgh, Caitlynd
   Huisman, Hugo W.
   Mels, Catharina M. C.
TI Cardiovascular reactivity and oxidative stress in young and older
   adults: the African-PREDICT and SABPA studies
SO BLOOD PRESSURE
LA English
DT Article
DE Acute stress; color-word conflict test; age; reactive oxygen species;
   glutathione metabolism
ID GAMMA-GLUTAMYL-TRANSFERASE; SUB-SAHARAN AFRICA; BLOOD-PRESSURE; MENTAL
   STRESS; ENDOTHELIAL DYSFUNCTION; METABOLIC SYNDROME; VASCULAR BIOLOGY;
   HYPERTENSION; MECHANISMS; BLACK
AB Background: Oxidative stress and increased cardiovascular reactivity are associated with endothelial dysfunction and cardiovascular disease development. These factors along with early vascular compromise are more pronounced in black populations. We aimed to compare cardiovascular reactivity and investigate associations thereof with oxidative stress in two bi-ethnic cohorts (younger: 25.03.19yrs; older: 44.79.61yrs).Methods: Cardiovascular reactivity using the color-word conflict test was measured with the Finometer device. Oxidative stress markers included superoxide dismutase (SOD), gamma-glutamyl transferase (gamma-GT) and reactive oxygen species (ROS).Results: Black groups displayed greater cardiovascular responses to stress than white groups. In younger white participants, diastolic blood pressure (DBP) (beta=0.31; p=0.001) and mean arterial blood pressure (MAP) (beta=0.28; p=0.002) associated with ROS. In older black participants, DBP (beta=0.23; p=0.009), MAP (beta=0.18; p=0.033), stroke volume (beta=-0.20; p=0.023) and arterial compliance (beta=-0.25; p=0.005) associated with gamma-GT. In older white participants, systolic blood pressure (beta=-0.20; p=0.006) and MAP (beta=-0.19; p=0.009) associated with SOD.Conclusions: In the older black group, cardiovascular reactivity associated with markers of glutathione metabolism, suggesting a possible compensatory up-regulation thereof in order to correct their heightened responses to stress. Independent of age, findings in the white groups support a regulatory role of ROS to maintain vascular tone during stress.
C1 [Myburgh, Caitlynd; Huisman, Hugo W.; Mels, Catharina M. C.] North West Univ, HART, Private Bag X6001, ZA-2520 Potchefstroom, South Africa.
   [Myburgh, Caitlynd] Univ South Africa UNISA, Roodepoort, South Africa.
   [Huisman, Hugo W.; Mels, Catharina M. C.] North West Univ, MRC Res Unit Hypertens & Cardiovasc Dis, Potchefstroom, South Africa.
C3 North West University - South Africa; University of South Africa; North
   West University - South Africa
RP Mels, CMC (corresponding author), North West Univ, HART, Private Bag X6001, ZA-2520 Potchefstroom, South Africa.
EM Carina.Mels@nwu.ac.za
RI Mels, Catharina/K-3172-2013
OI Myburgh, Caitlynd/0000-0001-5743-2910; Mels, Catharina
   MC/0000-0003-0138-3341; Huisman, Hugo/0000-0002-2114-4789
FU South African Medical Research Council (SAMRC); National Treasury under
   its Economic Competitiveness and Support Package; South African Research
   Chairs Initiative (SARChI) of the Department of Science and Technology;
   South African Research Chairs Initiative (SARChI) of the National
   Research Foundation (NRF) of South Africa [GUN 86895]; Strategic Health
   Innovation Partnerships (SHIP) Unit of the SAMRC; South African National
   Department of Health; UK Medical Research Council; UK Government's
   Newton Fund; Pfizer (South Africa); BoehringerIngelheim (South Africa);
   Novartis (South Africa); North-West University, Potchefstroom; National
   Research Foundation (NRF); ROCHE Diagnostics, South Africa; Department
   of Education, North-West Province; Metabolic Syndrome Institute, France;
   GlaxoSmithKline RD; Medi Clinic Hospital Group (South Africa); NRF
   Thuthuka [80643]
FX The research funded in this manuscript is part of an ongoing research
   project financially supported by the South African Medical Research
   Council (SAMRC) with funds from National Treasury under its Economic
   Competitiveness and Support Package; the South African Research Chairs
   Initiative (SARChI) of the Department of Science and Technology and
   National Research Foundation (NRF) of South Africa (GUN 86895); the
   Strategic Health Innovation Partnerships (SHIP) Unit of the SAMRC with
   funds received from the South African National Department of Health,
   GlaxoSmithKline R&D, the UK Medical Research Council and with funds from
   the UK Government's Newton Fund; as well as corporate social investment
   grants from Pfizer (South Africa), BoehringerIngelheim (South Africa),
   Novartis (South Africa), the Medi Clinic Hospital Group (South Africa)
   and in kind contributions of Roche Diagnostics (South Africa).The SABPA
   study was supported by the North-West University, Potchefstroom; the
   South African Medical Research Council (SAMRC), the National Research
   Foundation (NRF); the NRF Thuthuka (80643); ROCHE Diagnostics, South
   Africa, the Department of Education, North-West Province and the
   Metabolic Syndrome Institute, France.
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NR 41
TC 4
Z9 4
U1 0
U2 2
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
EI 1651-1999
J9 BLOOD PRESSURE
JI Blood Pressure
PY 2019
VL 28
IS 4
BP 229
EP 238
DI 10.1080/08037051.2019.1609348
PG 10
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Cardiovascular System & Cardiology
GA IJ4UW
UT WOS:000475900400003
PM 31030564
DA 2025-06-11
ER

PT J
AU Zeverdegani, SK
   Mohammadi, F
   Mohammadalipour, A
   Hashemnia, M
   Mohebian, Z
AF Zeverdegani, Sara Karimi
   Mohammadi, Farzaneh
   Mohammadalipour, Adel
   Hashemnia, Mohammad
   Mohebian, Zohreh
TI Health risks of welding fumes: A review to investigate the relationship
   between oxidative stress levels and trace metals in fluids of welders
SO ENVIRONMENTAL HEALTH ENGINEERING AND MANAGEMENT JOURNAL
LA English
DT Review
DE Oxidative stress; Antioxidants; Welding; Body fluids; Biomarkers
ID FREE-RADICAL PRODUCTION; LIPID-PEROXIDATION; STAINLESS-STEEL;
   OCCUPATIONAL-EXPOSURE; SERUM CONCENTRATIONS; PARKINSONS-DISEASE;
   MANGANESE EXPOSURE; METABOLIC SYNDROME; INTERNAL EXPOSURE; SHIPYARD
   WORKERS
AB Background: Welding fumes (WFs) contain heavy metals that can induce oxidative stress and health issues in welders. This review investigated the relationship between oxidative stress biomarkers and trace metals in welders' bodily fluids. Methods: Online databases such as Scopus, PubMed, Web of Science, Science Direct, EMBASE, and Google Scholar were reviewed, with a specific emphasis on the effects of metal fume exposure during welding. Specific keywords such as "welding fumes", "metal fumes", "antioxidant enzymes", "biomarkers", and similar terms were employed to search for articles published between 2004 and 2023. After the evaluation of article titles and abstracts, this study reviewed a total of 19 articles. Results: Studies suggest that welders experience oxidative stress due to changes in trace metals in their body fluids, affecting antioxidant enzymes and oxidative stress biomarkers. Elevated heavy metals in welders' biological samples lead to oxidative stress and inflammation, even at low levels. Certain metals in blood and urine, such as lead (Pb), manganese (Mn), iron (Fe), chromium (Cr), and cadmium (Cd), positively correlate with serum superoxide dismutase (SOD) and glutathione peroxidase (GPx) levels. There is also a significant positive correlation between serum/EBC MDA and blood/urine Pb, Mn, Cd, Cr, and Fe, indicating cellular damage, lipid peroxidation, and reduced antioxidant capacity. Additionally, welders may experience more DNA damage compared to non -welders. Conclusion: Exposure to WFs significantly altered oxidative stress biomarkers in bodily fluids, underscoring the importance of the relationship between oxidative stress and trace metal imbalances in WF-related injuries. These factors could serve as valuable biomarkers for monitoring workers exposed to WFs.
C1 [Zeverdegani, Sara Karimi] Isfahan Univ Med Sci, Sch Hlth, Dept Occupat Hlth Engn, Esfahan, Iran.
   [Mohammadi, Farzaneh] Isfahan Univ Med Sci, Sch Hlth, Dept Environm Hlth Engn, Esfahan, Iran.
   [Mohammadalipour, Adel] Isfahan Univ Med Sci, Fac Pharm & Pharmaceut Sci, Dept Clin Biochem, Esfahan, Iran.
   [Hashemnia, Mohammad] Razi Univ, Fac Vet Med, Dept Pathobiol, Kermanshah, Iran.
   [Mohebian, Zohreh] Isfahan Univ Med Sci, Student Res Comm, Sch Hlth, Dept Occupat Hlth Engn, Esfahan, Iran.
C3 Isfahan University of Medical Sciences; Isfahan University of Medical
   Sciences; Isfahan University of Medical Sciences; Razi University;
   Isfahan University of Medical Sciences
RP Mohebian, Z (corresponding author), Isfahan Univ Med Sci, Student Res Comm, Sch Hlth, Dept Occupat Hlth Engn, Esfahan, Iran.
EM zohreh.mohebian@gmail.com
RI Hashemnia, Mohammad/HGC-1644-2022; mohammadi, farzaneh/Y-3049-2018;
   Zeverdegani, sara/W-4765-2017
FU Isfahan University of Medical Sciences in Iran
FX This study was financially supported by Isfahan University of Medical
   Sciences in Iran.
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NR 167
TC 0
Z9 0
U1 2
U2 5
PU KERMAN UNIV MEDICAL SCIENCES
PI KERMAN
PA JAHAD BLVD, KERMAN, 7619813159, IRAN
SN 2423-3765
EI 2423-4311
J9 ENV HEALTH ENG MANAG
JI Environ. Health Eng. Manag.
PD SPR
PY 2024
VL 11
IS 2
BP 237
EP 256
DI 10.34172/EHEM.2024.24
PG 20
WC Environmental Sciences
WE Emerging Sources Citation Index (ESCI)
SC Environmental Sciences & Ecology
GA XQ3X7
UT WOS:001263118000001
OA gold
DA 2025-06-11
ER

PT J
AU Salvadó, L
   Barroso, E
   Gómez-Foix, AM
   Palomer, X
   Michalik, L
   Wahli, W
   Vázquez-Carrera, M
AF Salvado, Laia
   Barroso, Emma
   Gomez-Foix, Anna Maria
   Palomer, Xavier
   Michalik, Liliane
   Wahli, Walter
   Vazquez-Carrera, Manuel
TI PPARβ/δ prevents endoplasmic reticulum stress-associated inflammation
   and insulin resistance in skeletal muscle cells through an
   AMPK-dependent mechanism
SO DIABETOLOGIA
LA English
DT Article
DE AMPK; ER stress; ERK1/2; NF-kappa B; PPAR beta/delta
ID ACTIVATED PROTEIN-KINASE; METABOLIC SYNDROME; GLUCOSE-METABOLISM;
   DIABETES-MELLITUS; IN-VIVO; KAPPA-B; DELTA; INTERLEUKIN-6; EXPRESSION;
   OBESITY
AB Aim/hypothesis Endoplasmic reticulum (ER) stress, which is involved in the link between inflammation and insulin resistance, contributes to the development of type 2 diabetes mellitus. In this study, we assessed whether peroxisome proliferator-activated receptor (PPAR)beta/delta prevented ER stress-associated inflammation and insulin resistance in skeletal muscle cells.
   Methods Studies were conducted in mouse C2C12 myotubes, in the human myogenic cell line LHCN-M2 and in skeletal muscle from wild-type and PPAR beta/delta-deficient mice and mice exposed to a high-fat diet.
   Results The PPAR beta/delta agonist GW501516 prevented lipid-induced ER stress in mouse and human myotubes and in skeletal muscle of mice fed a high-fat diet. PPAR beta/delta activation also prevented thapsigargin- and tunicamycin-induced ER stress in human and murine skeletal muscle cells. In agreement with this, PPAR beta/delta activation prevented ER stress-associated inflammation and insulin resistance, and glucose-intolerant PPAR beta/delta-deficient mice showed increased phosphorylated levels of inositol-requiring 1 transmembrane kinase/endonuclease-1 alpha in skeletal muscle. Our findings demonstrate that PPAR beta/delta activation prevents ER stress through the activation of AMP-activated protein kinase (AMPK), and the subsequent inhibition of extracellular-signal-regulated kinase (ERK)1/2 due to the inhibitory crosstalk between AMPK and ERK1/2, since overexpression of a dominant negative AMPK construct (K45R) reversed the effects attained by PPAR beta/delta activation.
   Conclusions/interpretation Overall, these findings indicate that PPAR beta/delta prevents ER stress, inflammation and insulin resistance in skeletal muscle cells by activating AMPK.
C1 [Salvado, Laia; Barroso, Emma; Palomer, Xavier; Vazquez-Carrera, Manuel] Univ Barcelona, Fac Pharm, Dept Pharmacol & Therapeut Chem, E-08028 Barcelona, Spain.
   [Salvado, Laia; Barroso, Emma; Gomez-Foix, Anna Maria; Palomer, Xavier; Vazquez-Carrera, Manuel] Univ Barcelona, Inst Biomed, E-08028 Barcelona, Spain.
   [Salvado, Laia; Barroso, Emma; Gomez-Foix, Anna Maria; Palomer, Xavier; Vazquez-Carrera, Manuel] CIBERDEM, Spanish Biomed Res Ctr Diabet & Associated Metab, Barcelona, Spain.
   [Gomez-Foix, Anna Maria] Univ Barcelona, Fac Biol, Dept Biochem & Mol Biol, E-08028 Barcelona, Spain.
   [Michalik, Liliane; Wahli, Walter] Univ Lausanne, Ctr Integrat Gen, Natl Res Ctr Frontiers Genet, Lausanne, Switzerland.
   [Wahli, Walter] Nanyang Technol Univ, Lee Kong Chian Sch Med, Singapore 639798, Singapore.
C3 University of Barcelona; University of Barcelona; CIBER - Centro de
   Investigacion Biomedica en Red; CIBERDEM; University of Barcelona;
   University of Lausanne; Nanyang Technological University
RP Vázquez-Carrera, M (corresponding author), Univ Barcelona, Fac Pharm, Dept Pharmacol & Therapeut Chem, Diagonal 643, E-08028 Barcelona, Spain.
EM mvazquezcarrera@ub.edu
RI Wahli, Walter/I-3194-2019; Barroso, Emma/JXY-3878-2024; Barroso,
   Emma/G-9305-2018; Vazquez-Carrera, Manuel/H-2612-2015
OI Barroso, Emma/0000-0003-4551-4825; Vazquez-Carrera,
   Manuel/0000-0001-7138-8207; Palomer, Xavier/0000-0001-7647-9984;
   Michalik, Liliane/0000-0003-2963-2100
FU Spanish Ministerio de Economia y Competitividad [SAF2009-06939,
   SAF2012-30708]; European Union ERDF; Spanish Ministerio de Economia y
   Competitividad
FX This study was partly supported by funds from the Spanish Ministerio de
   Economia y Competitividad (SAF2009-06939 and SAF2012-30708) and the
   European Union ERDF. CIBER de Diabetes y Enfermedades Metabolicas
   Asociadas (CIBERDEM) is an Instituto de Salud Carlos III project. LS was
   supported by an FPI grant from the Spanish Ministerio de Economia y
   Competitividad. We thank the University of Barcelona's Language Advisory
   Service for revising the manuscript.
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NR 44
TC 84
Z9 92
U1 1
U2 44
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0012-186X
EI 1432-0428
J9 DIABETOLOGIA
JI Diabetologia
PD OCT
PY 2014
VL 57
IS 10
BP 2126
EP 2135
DI 10.1007/s00125-014-3331-8
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA AO9VZ
UT WOS:000341708900015
PM 25063273
DA 2025-06-11
ER

PT J
AU Cheng, JJ
   Xu, LQ
   Yu, QX
   Lin, GS
   Ma, XD
   Li, MY
   Guan, FK
   Liu, YH
   Huang, XQ
   Xie, JH
   Chen, JN
   Su, ZR
   Li, YC
AF Cheng, Juanjuan
   Xu, Lieqiang
   Yu, Qiuxia
   Lin, Guoshu
   Ma, Xingdong
   Li, Mengyao
   Guan, Fengkun
   Liu, Yuhong
   Huang, Xiaoqi
   Xie, Jianhui
   Chen, Jiannan
   Su, Ziren
   Li, Yucui
TI Metformin alleviates long-term high-fructose diet-induced skeletal
   muscle insulin resistance in rats by regulating purine nucleotide cycle
SO EUROPEAN JOURNAL OF PHARMACOLOGY
LA English
DT Article
DE Metformin; Fructose; Insulin resistance; Nrf2 signal pathway;
   Mitochondrial; Purine nucleotide cycle
ID ADENYLOSUCCINATE LYASE ADSL; INFLAMMATORY RESPONSE; DIABETES-MELLITUS;
   OXIDATIVE STRESS; ALPHA; DYSFUNCTION; DEFICIENCY; ACTIVATION;
   EXPRESSION; AMPK
AB Nutrient excess caused by excessive fructose intake can lead to insulin resistance and dyslipidemia, which further causes the development of metabolic syndrome. Metformin is a well-known AMPK activator widely used for the treatment of metabolic syndrome, while the mechanism of AMPK activation remains unclear. The present study aimed to investigate the pharmacological effects of metformin on fructose-induced insulin resistance rat, and the potential mechanism underlying AMPK activation in skeletal muscle tissue. Results indicated that metformin significantly ameliorated features of insulin resistance, including body weight, Lee's index, hyperinsulinemia, dyslipidemia, insulin intolerance and pancreatic damage. Moreover, treatment with metformin attenuated the inflammatory response in serum and enhanced the antioxidant capacity in skeletal muscle tissue. The therapeutic effects of metformin on fructose-induced insulin resistance may be related to the activation of AMPK to regulate Nrf2 pathway and mitochondrial abnormality. Additionally, metformin suppressed the expression of adenosine monophosphate deaminase 1 (AMPD1) and up-regulated the expression of adenylosuccinate synthetase (ADSS) in the purine nucleotide cycle (PNC), which facilitated the increase of AMP level and the ratio of AMP/ATP. Therefore, we proposed a novel mechanism that metformin activated AMPK via increasing AMP by regulating the expression of AMPD1 and ADSS in PNC pathway.
C1 [Cheng, Juanjuan; Xu, Lieqiang; Lin, Guoshu; Ma, Xingdong; Li, Mengyao; Guan, Fengkun; Liu, Yuhong; Huang, Xiaoqi; Chen, Jiannan; Su, Ziren; Li, Yucui] Guangzhou Univ Chinese Med, Sch Pharmaceut Sci, Guangzhou 510006, Peoples R China.
   [Xu, Lieqiang] Jiangxi Agr Univ, Coll Biosci & Bioengn, Nanchang 330045, Jiangxi, Peoples R China.
   [Yu, Qiuxia; Xie, Jianhui] Guangzhou Univ Chinese Med, Affiliated Hosp 2, Guangzhou 510120, Peoples R China.
   [Xie, Jianhui] Guangzhou Univ Chinese Med, Affiliated Hosp 2, State Key Lab Dampness Syndrome Chinese Med, Guangzhou 510120, Peoples R China.
   [Xie, Jianhui] Guangdong Prov Key Lab Clin Res Tradit Chinese Me, Guangzhou 510120, Peoples R China.
C3 Guangzhou University of Chinese Medicine; Jiangxi Agricultural
   University; Guangzhou University of Chinese Medicine; Guangzhou
   University of Chinese Medicine; Guangzhou University of Chinese Medicine
RP Su, ZR; Li, YC (corresponding author), Guangzhou Univ Chinese Med, Sch Pharmaceut Sci, Guangzhou 510006, Peoples R China.
EM suziren@gzucm.edu.cn; liyucui@gzucm.edu.cn
RI LI, Yucui/AAY-3123-2020; Yang, Zehao/AAL-3999-2021; Jiannan,
   Chen/JJC-8513-2023; Xiaoqi, Huang/AAK-7124-2020; Liu,
   Yuhong/AAT-9680-2021; Su, Zi-Ren/O-5014-2019
OI Xiaoqi, Huang/0000-0003-3401-5000
FU National Natural Foundation of China [82074082, 82104472]; Natural
   Science Foundation of Guangdong Province, China; Guangdong Science and
   Technology Planning Projects [2021A1515011490, 2021B1515140003,
   2022A1515011706]
FX This work was supported by research grants from the National Natural
   Foundation of China (Nos. 82074082 & 82104472) , the Natural Science
   Foundation of Guangdong Province, China, and the Guangdong Science and
   Technology Planning Projects (Nos. 2021A1515011490 & 2021B1515140003 &
   2022A1515011706) .
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NR 53
TC 9
Z9 10
U1 2
U2 30
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0014-2999
EI 1879-0712
J9 EUR J PHARMACOL
JI Eur. J. Pharmacol.
PD OCT 15
PY 2022
VL 933
AR 175234
DI 10.1016/j.ejphar.2022.175234
EA SEP 2022
PG 11
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 4W7NM
UT WOS:000860345000005
PM 36058289
DA 2025-06-11
ER

PT J
AU Schoenknecht, YB
   Crommen, S
   Stoffel-Wagner, B
   Coenen, M
   Fimmers, R
   Stehle, P
   Ramirez, A
   Egert, S
AF Schoenknecht, Yannik Bernd
   Crommen, Silke
   Stoffel-Wagner, Birgit
   Coenen, Martin
   Fimmers, Rolf
   Stehle, Peter
   Ramirez, Alfredo
   Egert, Sarah
TI APOE e4 Is Associated with Postprandial Inflammation in Older Adults
   with Metabolic Syndrome Traits
SO NUTRIENTS
LA English
DT Article
DE apolipoprotein E gene polymorphism; dietary pattern; inflammation;
   oxidative stress; postprandial state
ID APOLIPOPROTEIN-E GENOTYPE; BLOOD-PRESSURE; DIETARY; RISK;
   RESPONSIVENESS; MECHANISMS; DISEASE; IMPACT; SEX
AB The apolipoprotein E (APOE) polymorphism impacts blood lipids and biomarkers of oxidation and inflammation, contributing to an isoform-dependent disease risk. We investigated the effect of the APOE genotype on postprandial metabolism after consumption of three different isoenergetic (4200 kJ) meals in older adults with a CVD risk phenotype. In a randomized crossover study, participants with metabolic syndrome traits (APOE E3, n = 39; E4, n = 10; mean age, 70 & PLUSMN; 5 years; BMI 31.3 & PLUSMN; 3.0 kg/m(2)) consumed a Western-like diet high-fat (WDHF), Western-like diet high-carbohydrate (WDHC), or Mediterranean-like diet (MED) meal. Parameters of lipid and glucose metabolism, inflammatory, and oxidative parameters were analyzed in blood samples collected at fasting and 1-5 h postprandially. Data were analyzed by linear mixed models. The magnitude of the IL-6 increase after the WDHF meal was significantly higher in E4 than in E3 carriers (iAUC: E4 = 7.76 vs. E3 = 2.81 pg/mL x h). The time to detect the IL-6 increase was shorter in the E4 group. All meals produced postprandial glycemia, insulinemia, and lipidemia, without differences between the E3 and the E4 groups. IL-1 beta and oxidized LDL levels did not change postprandially. In conclusion, APOE E4 carriers display increased postprandial inflammation, indicated by higher postprandial IL-6 increase, when compared to non-carriers.
C1 [Schoenknecht, Yannik Bernd; Crommen, Silke; Stehle, Peter; Egert, Sarah] Univ Bonn, Dept Nutr & Food Sci, Nutr Physiol, D-53115 Bonn, Germany.
   [Stoffel-Wagner, Birgit] Univ Hosp Bonn, Inst Clin Chem & Clin Pharmacol, D-53127 Bonn, Germany.
   [Coenen, Martin] Univ Hosp Bonn, Study Ctr Bonn, Clin Study Core Unit, D-53127 Bonn, Germany.
   [Fimmers, Rolf] Univ Hosp Bonn, Inst Med Biometry Informat & Epidemiol, D-53127 Bonn, Germany.
   [Ramirez, Alfredo] Univ Hosp Cologne, Div Neurogenet & Mol Psychiat, Dept Psychiat & Psychotherapy, D-50931 Cologne, Germany.
   [Ramirez, Alfredo] Univ Hosp Bonn, Dept Neurodegenerat Dis & Geriatr Psychiat, D-53127 Bonn, Germany.
   [Ramirez, Alfredo] German Ctr Neurodegenerat Dis DZNE, D-53127 Bonn, Germany.
   [Ramirez, Alfredo] Dept Psychiat, San Antonio, TX 78229 USA.
   [Ramirez, Alfredo] Glenn Biggs Inst Alzheimers & Neurodegenerat Dis, San Antonio, TX 78229 USA.
   [Egert, Sarah] Univ Cologne, Excellence Cluster Cellular Stress Responses Agin, D-50931 Cologne, Germany.
C3 University of Bonn; University of Bonn; University of Bonn; University
   of Bonn; University of Cologne; University of Bonn; Helmholtz
   Association; German Center for Neurodegenerative Diseases (DZNE);
   University of Cologne
RP Egert, S (corresponding author), Univ Bonn, Dept Nutr & Food Sci, Nutr Physiol, D-53115 Bonn, Germany.
EM yschoenknecht@uni-bonn.de; s.crommen@uni-bonn.de;
   birgit.stoffel-wagner@ukbonn.de; martin.coenen@ukbonn.de;
   fimmers@imbie.meb.uni-bonn.de; p.stehle@uni-bonn.de;
   alfredo.ramirez@uk-koeln.de; s.egert@uni-bonn.de
RI Stehle, Peter/ITU-6185-2023; Ramirez, Alfredo/S-5126-2019
OI Crommen, Silke/0000-0002-9311-5004; Schonknecht,
   Yannik/0000-0002-7344-2526; Ramirez, Alfredo/0000-0003-4991-763X;
   Stehle, Peter/0000-0002-4596-8088
FU German Federal Ministry of Education and Research [01EA1372D]
FX This research was funded by the German Federal Ministry of Education and
   Research, grant number 01EA1372D.
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NR 34
TC 7
Z9 7
U1 1
U2 4
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD NOV
PY 2021
VL 13
IS 11
AR 3924
DI 10.3390/nu13113924
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA XK1ER
UT WOS:000727217600001
PM 34836179
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Ezzati-Mobaser, S
   Malekpour-Dehkordi, Z
   Nourbakhsh, M
   Tavakoli-Yaraki, M
   Ahmadpour, F
   Golpour, P
   Nourbakhsh, M
AF Ezzati-Mobaser, Samira
   Malekpour-Dehkordi, Zahra
   Nourbakhsh, Mona
   Tavakoli-Yaraki, Masoumeh
   Ahmadpour, Fatemeh
   Golpour, Pegah
   Nourbakhsh, Mitra
TI The up-regulation of markers of adipose tissue fibrosis by visfatin in
   pre-adipocytes as well as obese children and adolescents
SO CYTOKINE
LA English
DT Article
DE Obesity; Adipose tissue fibrosis; Visfatin; Collagen; Endotrophin;
   Osteopontin; Insulin resistance; Metabolic syndrome
ID TYPE-2 DIABETES-MELLITUS; COLONY-ENHANCING FACTOR; INSULIN-RESISTANCE;
   BREAST-CANCER; METABOLIC SYNDROME; PLASMA-LEVELS; MATRIX
   METALLOPROTEINASE-2; MESENCHYMAL TRANSITION; OXIDATIVE STRESS; SERUM
   VISFATIN
AB Adipocytes are surrounded by a three-dimensional network of extracellular matrix (ECM) proteins. Aberrant ECM accumulation and remodeling leads to adipose tissue fibrosis. Visfatin is one of the adipocytokines that is increased in obesity and is implicated in insulin resistance. The objective of this study was to investigate the effect of visfatin on major components of ECM remodeling. In this study, plasma levels of both endotrophin and visfatin in obese children and adolescents were significantly higher than those in control subjects and they showed a positive correlation with each other. Treatment of 3T3-L1 pre-adipocytes with visfatin caused significant up-regulation of Osteopontin (Opn), Collagen type VI (Co16), matrix metalloproteinases MMP-2 and MMP-9. By using inhibitors of major signaling pathways it was shown that visfatin exerted its effect on Col6a3 gene expression through PI3K, JNK, and NF-kappa B pathways, while induced Opn gene expression via PI3K, JNK, MAPK/ERK, and NOTCH1. Our conclusion is that, the relationship between visfatin, endotrophin and insulin resistance parameters in obesity as well as increased expression of ECM proteins by visfatin suggests adipose tissue fibrosis as a mechanism for devastating effects of visfatin in obesity.
C1 [Ezzati-Mobaser, Samira; Tavakoli-Yaraki, Masoumeh; Golpour, Pegah; Nourbakhsh, Mitra] Iran Univ Med Sci, Fac Med, Dept Biochem, Tehran 1449614535, Iran.
   [Malekpour-Dehkordi, Zahra] Univ Tehran Med Sci, Metab Disorders Res Ctr, Endocrinol & Metab Mol Cellular Sci Inst, Tehran, Iran.
   [Nourbakhsh, Mona] Iran Univ Med Sci, Hazrat Aliasghar Childrens Hosp, Tehran, Iran.
   [Ahmadpour, Fatemeh] Ahvaz Jundishapur Univ Med Sci, Fac Med, Dept Clin Biochem, Ahvaz, Iran.
   [Nourbakhsh, Mitra] Iran Univ Med Sci, Finetech Med Res Ctr, Tehran, Iran.
C3 Iran University of Medical Sciences; Tehran University of Medical
   Sciences; Iran University of Medical Sciences; Ahvaz Jundishapur
   University of Medical Sciences (AJUMS); Iran University of Medical
   Sciences
RP Nourbakhsh, M (corresponding author), Iran Univ Med Sci, Fac Med, Dept Biochem, Tehran 1449614535, Iran.
EM nourbakhsh.m@iums.ac.ir
RI golpour, pegah/HOC-1412-2023; Nourbakhsh, Mitra/D-5214-2018; nourbakhsh,
   Mona/O-9521-2018; Ahmadpour, Fatemeh/ITV-1197-2023; Mobaser,
   Samira/AAD-2630-2021
FU Iran University of Medical Sciences [95-04-30-29356]
FX This research was financially supported by grant number 95-04-30-29356
   from Iran University of Medical Sciences. This study was approved by the
   ethics committee of Iran University of Medical Sciences.
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NR 74
TC 27
Z9 27
U1 0
U2 8
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 1043-4666
EI 1096-0023
J9 CYTOKINE
JI Cytokine
PD OCT
PY 2020
VL 134
AR 155193
DI 10.1016/j.cyto.2020.155193
PG 9
WC Biochemistry & Molecular Biology; Cell Biology; Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology; Immunology
GA NS6QJ
UT WOS:000572383500016
PM 32707422
DA 2025-06-11
ER

PT J
AU Welge, JA
   Warshak, CR
   Woollett, LA
AF Welge, Jeffrey A.
   Warshak, Carri R.
   Woollett, Laura A.
TI Maternal plasma cholesterol concentration and preterm birth: a
   meta-analysis and systematic review of literature
SO JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
LA English
DT Review
DE Gestational age; HDL; LDL; pregnancy; preterm labor
ID HIGH-DENSITY-LIPOPROTEIN; METABOLIC SYNDROME; OXIDATIVE STRESS;
   EARLY-PREGNANCY; LIPID PROFILE; FETAL-GROWTH; RISK-FACTORS; OUTCOMES;
   WOMEN; RATES
AB Background: Women that previously had preterm labor are at an increased risk for heart disease. Because spontaneous preterm birth is an adverse pregnancy outcome that affects millions of children worldwide, our objective was to review and analyze studies that have examined associations between maternal total cholesterol (TC), LDL-C, and HDL-C concentrations during pregnancy and the risk of preterm birth to potentially define biomarkers or targets for treatment. Method: A search was performed and 22 articles were found that examined the association of maternal plasma cholesterol concentrations and preterm birth. A meta-analysis was performed on 10 of the articles, those that used maternal lipid concentrations as the outcome and presented results as means plus variables, and a qualitative review was performed on all 22 articles. Results: The meta-analysis showed no relationship between maternal TC, LDL-C, or HDL-C and increased risk of preterm birth, although, a near significant relationship between low maternal HDL-C concentration and preterm birth (p = .055). Importantly, associations increased when cholesterol concentrations were combined with inflammatory markers or metabolic syndrome factors. Conclusions: The relationship between maternal cholesterol levels and preterm birth is heterogeneous. Associations are strengthened when maternal cholesterol concentrations are combined with other factors that may be related to more recently defined lipoprotein functions.
C1 [Welge, Jeffrey A.] Univ Cincinnati, Sch Med, Dept Psychiat & Behav Neurosci, Cincinnati, OH 45221 USA.
   [Warshak, Carri R.] Univ Cincinnati, Sch Med, Dept Obstet & Gynecol, Cincinnati, OH USA.
   [Woollett, Laura A.] Univ Cincinnati, Sch Med, Dept Pathol & Lab Med, Cincinnati, OH USA.
C3 University System of Ohio; University of Cincinnati; University System
   of Ohio; University of Cincinnati; University System of Ohio; University
   of Cincinnati
RP Woollett, LA (corresponding author), Univ Cincinnati, Reading Campus,2180 East Galbreith Rd, Cincinnati, OH 45215 USA.
EM laura.woollett@uc.edu
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NR 63
TC 4
Z9 5
U1 0
U2 4
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1476-7058
EI 1476-4954
J9 J MATERN-FETAL NEO M
JI J. Matern.-Fetal Neonatal Med.
PD JUL 2
PY 2020
VL 33
IS 13
BP 2291
EP 2299
DI 10.1080/14767058.2018.1542679
PG 9
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA LM9TH
UT WOS:000532589900021
PM 30373419
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Varela-López, A
   Bullón, P
   Ramírez-Tortosa, CL
   Navarro-Hortal, MD
   Robles-Almazán, M
   Bullón, B
   Cordero, MD
   Battino, M
   Quiles, JL
AF Varela-Lopez, Alfonso
   Bullon, Pedro
   Ramirez-Tortosa, Cesar L.
   Navarro-Hortal, Maria D.
   Robles-Almazan, Maria
   Bullon, Beatriz
   Cordero, Mario D.
   Battino, Maurizio
   Quiles, Jose L.
TI A Diet Rich in Saturated Fat and Cholesterol Aggravates the Effect of
   Bacterial Lipopolysaccharide on Alveolar Bone Loss in a Rabbit Model of
   Periodontal Disease
SO NUTRIENTS
LA English
DT Article
DE atherogenic; atherosclerosis; NASH; non-alcoholic fatty liver disease;
   periodontal diseases; periodontitis; rabbits
ID DENSITY-LIPOPROTEIN CHOLESTEROL; CARDIOVASCULAR-DISEASE;
   LIPID-PEROXIDATION; OXIDATIVE STRESS; NONALCOHOLIC STEATOHEPATITIS;
   METABOLIC SYNDROME; REACTIVE OXYGEN; NADPH OXIDASE; LIVER; INFLAMMATION
AB Increasing evidence connects periodontitis with a variety of systemic diseases, including metabolic syndrome, atherosclerosis, and non-alcoholic fatty liver disease (NAFLD). The proposal of this study was to evaluate the role of diets rich in saturated fat and cholesterol in some aspects of periodontal diseases in a lipopolysaccharide (LPS)-induced model of periodontal disease in rabbits and to assess the influence of a periodontal intervention on hyperlipidemia, atherosclerosis, and NAFLD progression to non-alcoholic steatohepatitis. Male rabbits were maintained on a commercial standard diet or a diet rich in saturated fat (3% lardw/w) and cholesterol (1.3%w/w) (HFD) for 40 days. Half of the rabbits on each diet were treated 2 days per week with intragingival injections of LPS fromPorphyromonas gingivalis. Morphometric analyses revealed that LPS induced higher alveolar bone loss (ABL) around the first premolar in animals receiving standard diets, which was exacerbated by the HFD diet. A higher score of acinar inflammation in the liver and higher blood levels of triglycerides and phospholipids were found in HFD-fed rabbits receiving LPS. These results suggest that certain dietary habits can exacerbate some aspects of periodontitis and that bad periodontal health can contribute to dyslipidemia and promote NAFLD progression, but only under certain conditions.
C1 [Varela-Lopez, Alfonso; Navarro-Hortal, Maria D.; Quiles, Jose L.] Univ Granada, Biomed Res Ctr, Inst Nutr & Food Technol Jose Mataix Verdu, Dept Physiol, Avda Conocimiento Sn, Granada 18016, Spain.
   [Bullon, Pedro; Bullon, Beatriz] Univ Seville, Dent Sch, Dept Stomal, C Avicena Sn, Seville 41009, Spain.
   [Ramirez-Tortosa, Cesar L.] Hosp San Cecilio Granada, UGC Anat Patol, Avda Conocimiento S-N, Granada 18100, Spain.
   [Robles-Almazan, Maria] Jaen Hosp, Pathol Anat Dept, Jaen 23007, Spain.
   [Cordero, Mario D.] Univ Europea Atlantico UNEATLANTICO, Catedra Reprod & Genet Humana, Inst Estudio Biol Reprod Humana INEBIR, Fdn Univ Iberoamer FUNIBER, Santander 39011, Spain.
   [Cordero, Mario D.] Newcastle Univ, Newcastle Inst Ageing, Campus Ageing & Hlth, Newcastle Upon Tyne NE4 5PL, Tyne & Wear, England.
   [Cordero, Mario D.] Newcastle Univ, Inst Cell & Mol Biol, Campus Ageing & Hlth, Newcastle Upon Tyne NE4 5PL, Tyne & Wear, England.
   [Battino, Maurizio] Univ Politecn Marche, Dept Clin Sicences, I-60131 Ancona, Italy.
   [Battino, Maurizio] Univ Vigo, Dept Analyt & Food Chem, CITACA, Nutr & Food Sci Grp,CACTI, Vigo 36310, Spain.
   [Battino, Maurizio] Jiangsu Univ, Int Res Ctr Food Nutr & Safety, Zhenjiang 212013, Jiangsu, Peoples R China.
   [Quiles, Jose L.] Northwest Univ, Coll Food Sci & Technol, Xian 710069, Peoples R China.
C3 University of Granada; University of Sevilla; Newcastle University - UK;
   Newcastle University - UK; Marche Polytechnic University; Universidade
   de Vigo; Jiangsu University; Northwest University Xi'an
RP Quiles, JL (corresponding author), Univ Granada, Biomed Res Ctr, Inst Nutr & Food Technol Jose Mataix Verdu, Dept Physiol, Avda Conocimiento Sn, Granada 18016, Spain.; Quiles, JL (corresponding author), Northwest Univ, Coll Food Sci & Technol, Xian 710069, Peoples R China.
EM alvarela@ugr.es; pbullon@us.es; cesarl.ramirez.sspa@juntadeandalucia.es;
   mdnavarro@ugr.es; maria.robles.exts@juntadeandalucia.es;
   beatrizbullon@hotmail.com; mdcormor@us.es; m.a.battino@univpm.it;
   Jlquiles@ugr.es
RI Battino, Maurizio/E-6103-2012; Quiles, José/C-6911-2013; Varela-López,
   Alfonso/F-8055-2016; Ramírez-Tortosa, César/F-2055-2016; Cordero,
   Mario/L-8006-2014; Navarro-Hortal, María/AAB-9805-2019; RoblesAlmazan,
   Maria/LIC-6578-2024; Bullon, Pedro/E-6319-2010
OI Navarro-Hortal, Maria D./0000-0002-6225-8379; Bullon,
   Pedro/0000-0003-4873-4196
FU Visiting Scholar Program from the University of Granada
FX Maria D. Navarro-Hortal is a FPU fellow from the Spanish Ministry of
   Educacion y Formacion Profesional. The research group was partially
   supported by the Visiting Scholar Program from the University of
   Granada. The authors acknowledge Nutraceutical Translations for English
   language editing of this manuscript.
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NR 78
TC 11
Z9 11
U1 0
U2 21
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD MAY
PY 2020
VL 12
IS 5
AR 1405
DI 10.3390/nu12051405
PG 16
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA MB0AV
UT WOS:000542272700184
PM 32422858
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Aranaz, P
   Romo-Hualde, A
   Navarro-Herrera, D
   Zabata, M
   López-Yoldi, M
   González-Ferrero, C
   Gil, AG
   Martínez, JA
   Vizmanos, JL
   Milagro, FI
   González-Navarro, CJ
AF Aranaz, Paula
   Romo-Hualde, Ana
   Navarro-Herrera, David
   Zabata, Maria
   Lopez-Yoldi, Miguel
   Gonzalez-Ferrero, Carolina
   Gloria Gil, Ana
   Alfredo Martinez, J.
   Luis Vizmanos, Jose
   Milagro, Fermin, I
   Gonzalez-Navarro, Carlos J.
TI Low doses of cocoa extract supplementation ameliorate diet-induced
   obesity and insulin resistance in rats
SO FOOD & FUNCTION
LA English
DT Article
ID IMPROVE METABOLIC SYNDROME; DARK CHOCOLATE; OXIDATIVE STRESS;
   BLOOD-PRESSURE; RISK-FACTORS; ADIPOCYTE DIFFERENTIATION; GLUCOSE-LEVELS;
   FAT; SENSITIVITY; PROCYANIDIN
AB Cocoa polyphenols exhibit high antioxidant activity and have been proposed as a potential adjuvant for the treatment of metabolic disturbances. Here, we demonstrate that supplementation with low doses (14 and 140 mg per kg per rat) of a complete cocoa extract induces metabolic benefits in a diet-induced obesity (DIO) model of Wistar rats. After 10 weeks, cocoa extract-supplemented animals exhibited significantly lower body weight gain and food efficiency, with no differences in energy intake. Cocoa significantly reduced visceral (epididymal and retroperitoneal) and subcutaneous fat accumulation accompanied by a significant reduction in the adipocyte size, which was mediated by downregulation of the adipocyte-specific genes Cebpa, Fasn and Adipoq. Additionally, cocoa extract supplementation reduced the triacylglycerol/high density lipoprotein (TAG/HDL) ratio, decreased hepatic triglyceride accumulation, improved insulin sensitivity by reducing HOMA-IR, and significantly ameliorated glucose tolerance after an intraperitoneal glucose tolerance test. Finally, no adverse effect was observed in an in vivo toxicity evaluation of our cocoa extract at doses up to 500 mg kg(-1) day(-1). Our data demonstrate that low doses of cocoa extract supplementation (14 and 140 mg kg(-1) day(-1)) are safe and sufficient to counteract obesity and type-2 diabetes in rats and provide new insights into the potential application of cocoa supplements in the management of the metabolic syndrome.
C1 [Aranaz, Paula; Romo-Hualde, Ana; Navarro-Herrera, David; Zabata, Maria; Lopez-Yoldi, Miguel; Alfredo Martinez, J.; Milagro, Fermin, I; Gonzalez-Navarro, Carlos J.] Univ Navarra, Ctr Nutr Res, Pamplona, Spain.
   [Aranaz, Paula; Alfredo Martinez, J.; Luis Vizmanos, Jose; Milagro, Fermin, I] Navarra Inst Hlth Res IdiSNA, Pamplona, Spain.
   [Navarro-Herrera, David; Luis Vizmanos, Jose] Univ Navarra, Dept Biochem & Genet, Pamplona, Spain.
   [Gonzalez-Ferrero, Carolina] Natl Ctr Food Safety & Technol CNTA, Res & Dev Area, San Adrian Navarra, Spain.
   [Gloria Gil, Ana] Univ Navarra, Dept Pharmacol & Toxicol, Pamplona, Spain.
   [Gloria Gil, Ana] Univ Navarra DDUNAV, Drug Dev Unit, Toxicol Unit, Pamplona, Spain.
   [Alfredo Martinez, J.] Univ Navarra, Dept Nutr Food Sci & Physiol, Pamplona, Spain.
   [Alfredo Martinez, J.; Milagro, Fermin, I] Spanish Biomed Res Ctr Physiopathol Obes & Nutr C, Madrid, Spain.
C3 University of Navarra; University of Navarra; University of Navarra;
   University of Navarra; University of Navarra; University of Navarra
RP Milagro, FI; González-Navarro, CJ (corresponding author), Univ Navarra, Ctr Nutr Res, Pamplona, Spain.; Milagro, FI (corresponding author), Navarra Inst Hlth Res IdiSNA, Pamplona, Spain.; Milagro, FI (corresponding author), Spanish Biomed Res Ctr Physiopathol Obes & Nutr C, Madrid, Spain.
EM fmilagro@unav.es; cgnavarro@unav.es
RI Milagro, Fermin/F-2315-2015; González Navarro, Carlos
   Javier/G-6959-2015; Gil, Ana G./ABG-7426-2020; Martinez Hernandez, J
   Alfredo/K-8709-2014; Vizmanos, Jose Luis/G-2833-2012; Romo Hualde,
   Ana/G-2428-2016
OI Gil, Ana G./0000-0002-1595-3395; Martinez Hernandez, J
   Alfredo/0000-0001-5218-6941; Vizmanos, Jose Luis/0000-0001-7416-3679;
   Gonzalez-Navarro, Carlos Javier/0000-0002-3517-9077; Milagro, Fermin
   I./0000-0002-3228-9916; Romo Hualde, Ana/0000-0001-6370-0707
FU Government of Navarra [IIM14672.RI1, PC008/PC063-064/PC027-28]
FX This project was funded by the Government of Navarra (Grant number
   IIM14672.RI1 and PC008/PC063-064/PC027-28).
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NR 60
TC 18
Z9 18
U1 1
U2 26
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PD AUG 1
PY 2019
VL 10
IS 8
BP 4811
EP 4822
DI 10.1039/c9fo00918c
PG 12
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA IR5NV
UT WOS:000481481700027
PM 31317981
DA 2025-06-11
ER

PT J
AU Tsai, WN
   Wang, YY
   Liang, JT
   Lin, SY
   Sheu, WHH
   Chang, WD
AF Tsai, Wan-Ni
   Wang, Ya-Yu
   Liang, Jiin-Tsae
   Lin, Shih-Yi
   Sheu, Wayne Huey-Herng
   Chang, Wen-Dau
TI Serum total bilirubin concentrations are inversely associated with total
   white blood cell counts in an adult population
SO ANNALS OF CLINICAL BIOCHEMISTRY
LA English
DT Article
DE Bilirubin; cardiovascular disease; inflammation; white blood cell count
ID LOW-DENSITY-LIPOPROTEIN; ISCHEMIC-HEART-DISEASE; METABOLIC SYNDROME;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; CIGARETTE-SMOKE; RISK;
   INFLAMMATION; ANTIOXIDANT; ATHEROSCLEROSIS
AB Background Several studies have shown that serum bilirubin has a protective effect against cardiovascular disease and that inflammation plays an important role in its pathogenesis. This cross-sectional study investigated whether there was an association between blood total white blood cell count, a simple indicator of inflammation, and serum total bilirubin concentration in a cohort of an adult population in Taiwan.
   Methods A total of 2458 apparently healthy adults (1246 men and 1212 women) who attended health examination at a medical centre in central Taiwan were enrolled. We collected anthropometric measurements, fasting blood test results, lifestyle habits and medical history.
   Results Total white blood cell counts decreased progressively when the concentrations of total bilirubin increased as demonstrated in the total bilirubin quartiles. Both total bilirubin concentrations and total white blood cell counts showed significant correlations with the components of metabolic syndrome, including triglyceride and high-density lipoprotein cholesterol concentrations. Multivariate linear regression analysis revealed that, for both genders, total bilirubin showed an independent negative correlation with total white blood cell count after adjusting for conventional cardiovascular risk factors.
   Conclusions Higher serum total bilirubin concentrations within the reference range were associated with lower blood total white blood cell counts, regardless of other classical cardiovascular risk factors.
C1 [Tsai, Wan-Ni] Tungs Taichung MetroHarbor Hosp, Div Endocrinol & Metab, Dept Internal Med, Taichung, Taiwan.
   [Wang, Ya-Yu; Chang, Wen-Dau] Taichung Vet Gen Hosp, Dept Family Med, Taichung 40705, Taiwan.
   [Wang, Ya-Yu] Natl Chung Hsing Univ, Dept Vet Med, Coll Vet Med, Taichung 40227, Taiwan.
   [Wang, Ya-Yu; Lin, Shih-Yi; Sheu, Wayne Huey-Herng] Natl Yang Ming Univ, Sch Med, Taipei 112, Taiwan.
   [Liang, Jiin-Tsae] Taichung Vet Gen Hosp, Dept Pathol & Lab Med, Div Biochem, Taichung 40705, Taiwan.
   [Lin, Shih-Yi; Sheu, Wayne Huey-Herng] Taichung Vet Gen Hosp, Div Endocrinol & Metab, Dept Internal Med, Taichung 40705, Taiwan.
   [Sheu, Wayne Huey-Herng] Natl Def Med Ctr, Sch Med, Taipei, Taiwan.
C3 Tungs' Taichung MetroHarbor Hospital; Taichung Veterans General
   Hospital; National Chung Hsing University; National Yang Ming Chiao Tung
   University; Taichung Veterans General Hospital; Taichung Veterans
   General Hospital; National Defense Medical Center
RP Chang, WD (corresponding author), Taichung Vet Gen Hosp, Dept Family Med, 1650 Taiwan Blvd Sect 4, Taichung 40705, Taiwan.
EM wdchang@vghtc.gov.tw
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NR 39
TC 15
Z9 15
U1 0
U2 14
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0004-5632
EI 1758-1001
J9 ANN CLIN BIOCHEM
JI Ann. Clin. Biochem.
PD MAR
PY 2015
VL 52
IS 2
BP 251
EP 258
DI 10.1177/0004563214541969
PG 8
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA CC6PM
UT WOS:000350488000011
PM 24923275
OA Bronze
DA 2025-06-11
ER

PT J
AU Li, JJ
   Fang, CH
   Hui, RT
AF Li, JJ
   Fang, CH
   Hui, RT
TI Is hypertension an inflammatory disease?
SO MEDICAL HYPOTHESES
LA English
DT Article
ID C-REACTIVE PROTEIN; ENDOTHELIAL DYSFUNCTION; MACROPHAGE INFILTRATION;
   METABOLIC SYNDROME; ANGIOTENSIN-II; LIPID PROFILE; RISK; RATS;
   ATHEROSCLEROSIS; SIMVASTATIN
AB Hypertension has been recognized as a multi-factorial trait resulting from the effect of a combination of environmental and genetic factors, including excess dietary salt or alcohol intake, stress, age, genetics and family history, obesity, physical inactivity, as well as high saturated fat diet. During the past few years, however, a large amount of information has been collected on the vascular inflammation, indicating that inflammation may involve in the initiation as well as development of hypertension and allowing us to reconsidering the pathogenic mechanisms of hypertension.
   Evidence from animal models as well as patients, have indicated that hypertension, an established major risk factor for coronary artery disease, has been suggested to exert pro-inflammatory actions through the increased expression of several mediators, including leukocyte adhesion molecules, chemokines, specific growth factors, heat shock proteins, endothelin-1, and angiotensin. The association between inflammation and hypertension recalls also a similar association between low-grade inflammation and other components of the metabolic syndrome, and endothelial dysfunction as well as increased serum levels of C-reactive protein in patients with hypertension.
   Is hypertension an inflammatory disease? This question has stimulated research on the role of vascular inflammation in hypertension. A better understanding of the inflammatory mechanism in hypertension may, therefore, contribute to novel therapeutic strategies to decrease the morbidity as well as mortality of hypertension, and alleviated hypertensive target organ damage. (C) 2004 Elsevier Ltd. All rights reserved.
C1 Wuhan Univ, Sch Med, Renmin Hosp, Dept Cardiol, Wuhan 430060, Peoples R China.
   Tsing Hua Univ, Sch Med, Ctr Heart, Affiliated Hosp 1, Beijing 100016, Peoples R China.
   Fuwai Hosp, Dept Cardiol, Beijing 100037, Peoples R China.
   Chinese Acad Med Sci, Cardiovasc Inst, Beijing 100037, Peoples R China.
   Peking Union Med Coll, Beijing 100037, Peoples R China.
C3 Wuhan University; Tsinghua University; Chinese Academy of Medical
   Sciences - Peking Union Medical College; Fu Wai Hospital - CAMS; Chinese
   Academy of Medical Sciences - Peking Union Medical College; Chinese
   Academy of Medical Sciences - Peking Union Medical College; Peking Union
   Medical College
RP Wuhan Univ, Sch Med, Renmin Hosp, Dept Cardiol, Wuhan 430060, Peoples R China.
EM lijnjn@yahoo.com.cn
CR [Anonymous], BR J OBSTET GYNECOL
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NR 32
TC 72
Z9 85
U1 1
U2 3
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0306-9877
EI 1532-2777
J9 MED HYPOTHESES
JI Med. Hypotheses
PY 2005
VL 64
IS 2
BP 236
EP 240
DI 10.1016/j.mehy.2004.06.017
PG 5
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 886UP
UT WOS:000226258500003
PM 15607546
DA 2025-06-11
ER

PT J
AU Van Gulick, L
   Saby, C
   Mayer, C
   Fossier, E
   Jaisson, S
   Okwieka, A
   Gillery, P
   Chenais, B
   Mimouni, V
   Morjani, H
   Beljebbar, A
AF Van Gulick, Laurence
   Saby, Charles
   Mayer, Claire
   Fossier, Emilie
   Jaisson, Stephane
   Okwieka, Anais
   Gillery, Philippe
   Chenais, Benoit
   Mimouni, Virginie
   Morjani, Hamid
   Beljebbar, Abdelilah
TI Biochemical and morpho-mechanical properties, and structural
   organization of rat tail tendon collagen in diet-induced obesity model
SO INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
LA English
DT Article
DE Metabolic syndrome; Obesity; Type I collagen; Morpho-mechanical
   properties; Polarized Raman spectroscopy
ID HIGH-FAT DIET; METABOLIC SYNDROME; RAMAN; TENDINOPATHY; GLYCATION;
   MATRIX; PATHOGENESIS; LINK; HYPERCHOLESTEROLEMIA; DEGRADATION
AB We have investigated the impact of obesity on the structural organization, morpho-mechanical collagen fibers from rat tail tendon fascicles (RTTFs). Polarized Raman microspectroscopy showed collagen bands 855, 875, 938, and 960 cm(-1) as well as those 1631 and 1660 cm(-1) were affected chanical properties exhibited an increase in the yield strength from control (CTRL) to high fat (HF) 1.71 and 13.09 +/- 1.81 MPa) (p < 0.01) and ultimate tensile strength (13.12 +/- 2.37 and 18.32 +/- 0.05) with no significant change in the Young's Modulus. During mechanical, the band at 875 cm(-1) most relevant frequency shift (2 cm(-1)). The intensity of those at 855, 875, and 938 cm-1 in HF played a comparable response to mechanical stress as compared to CTRL collagen with no significant changes in the Full Width at Half Maximum. Second harmonic generation technique revealed straightness (0.963 +/- 0.004 and 0.965 +/- 0.003) and ii) significant changes in fibers diameter (1.48 1.52 +/- 0.08 mu m) (p < 0.05) and length (22.06 +/- 2.38 and 29.00 +/- 3.76 mu m) (p < 0.001) between diet, respectively. The quantification of advanced glycation end products (AGEs) revealed an increase carboxymethyl-lysine and total fluorescence AGEs from CTRL to HF RTTFs.
C1 [Van Gulick, Laurence; Saby, Charles; Fossier, Emilie; Morjani, Hamid; Beljebbar, Abdelilah] Univ Reims, BioSpecT EA 7506, UFR Pharm, 51 Rue Cognacq Jay, F-51096 Reims, France.
   [Mayer, Claire; Mimouni, Virginie] Le Mans Univ, Inst Univ Technol, Dept Genie Biol, BiOSSE,Biol Organisms,Stress,Hlth,Environm, F-53020 Laval, France.
   [Jaisson, Stephane; Okwieka, Anais; Gillery, Philippe] Univ Reims, MEDyC CNRS UMR 7369, UFR Med, F-51097 Reims, France.
   [Jaisson, Stephane; Gillery, Philippe] Ctr Hosp Univ, Serv Biochim Pharmacol Toxicol, Reims, France.
   [Chenais, Benoit] Le Mans Univ, BiOSSE, Biol Organisms, UFR Sci & Tech,Stress,Hlth,Environm, F-72085 Le Mans, France.
C3 Universite de Reims Champagne-Ardenne; Le Mans Universite; Centre
   National de la Recherche Scientifique (CNRS); CNRS - National Institute
   for Biology (INSB); Universite de Reims Champagne-Ardenne; CHU de Reims;
   CHU de Toulouse; Universite de Reims Champagne-Ardenne; Le Mans
   Universite
RP Beljebbar, A (corresponding author), Univ Reims, BioSpecT EA 7506, UFR Pharm, 51 Rue Cognacq Jay, F-51096 Reims, France.
EM abdelilah.beljebbar@univ-reims.fr
RI Chénais, Benoît/C-6465-2009; Saby, Charles/GQZ-6933-2022
OI Saby, Charles/0000-0002-6203-2548; VAN GULICK,
   Laurence/0000-0003-0000-1161; Chenais, Benoit/0000-0003-2441-1966
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NR 83
TC 0
Z9 0
U1 2
U2 11
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0141-8130
EI 1879-0003
J9 INT J BIOL MACROMOL
JI Int. J. Biol. Macromol.
PD JAN
PY 2024
VL 254
AR 127936
DI 10.1016/j.ijbiomac.2023.127936
EA NOV 2023
PN 3
PG 15
WC Biochemistry & Molecular Biology; Chemistry, Applied; Polymer Science
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry; Polymer Science
GA Z5SY5
UT WOS:001112682700001
PM 37939767
OA Bronze
DA 2025-06-11
ER

PT J
AU Rodrigues, PM
   Afonso, MB
   Simao, AL
   Carvalho, CC
   Trindade, A
   Duarte, A
   Borralho, PM
   Machado, MV
   Cortez-Pinto, H
   Rodrigues, CMP
   Castro, RE
AF Rodrigues, Pedro M.
   Afonso, Marta B.
   Simao, Andre L.
   Carvalho, Catarina C.
   Trindade, Alexandre
   Duarte, Antonio
   Borralho, Pedro M.
   Machado, Mariana V.
   Cortez-Pinto, Helena
   Rodrigues, Ceclia M. P.
   Castro, Rui E.
TI miR-21 ablation and obeticholic acid ameliorate nonalcoholic
   steatohepatitis in mice
SO CELL DEATH & DISEASE
LA English
DT Article
ID FARNESOID X RECEPTOR; FATTY LIVER-DISEASE; INSULIN-RESISTANCE;
   CHOLINE-DEFICIENT; DIET; MICRORNAS; EXPRESSION; CASPASE-2; FIBROSIS;
   PATHWAY
AB microRNAs were recently suggested to contribute to the pathogenesis of nonalcoholic fatty liver disease (NAFLD), a disease lacking specific pharmacological treatments. In that regard, nuclear receptors are arising as key molecular targets for the treatment of nonalcoholic steatohepatitis (NASH). Here we show that, in a typical model of NASH-associated liver damage, microRNA-21 (miR-21) ablation results in a progressive decrease in steatosis, inflammation and lipoapoptosis, with impairment of fibrosis. In a complementary fast food (FF) diet NASH model, mimicking features of the metabolic syndrome, miR-21 levels increase in both liver and muscle, concomitantly with decreased expression of peroxisome proliferator-activated receptor alpha (PPAR alpha), a key miR-21 target. Strikingly, miR-21 knockout mice fed the FF diet supplemented with farnesoid X receptor (FXR) agonist obeticholic acid (OCA) display minimal steatosis, inflammation, oxidative stress and cholesterol accumulation. In addition, lipoprotein metabolism was restored, including decreased fatty acid uptake and polyunsaturation, and liver and muscle insulin sensitivity fully reinstated. Finally, the miR-21/PPAR alpha axis was found amplified in liver and muscle biopsies, and in serum, of NAFLD patients, co-substantiating its role in the development of the metabolic syndrome. By unveiling that miR-21 abrogation, together with FXR activation by OCA, significantly improves whole body metabolic parameters in NASH, our results highlight the therapeutic potential of nuclear receptor multi-targeting therapies for NAFLD.
C1 [Rodrigues, Pedro M.; Afonso, Marta B.; Simao, Andre L.; Borralho, Pedro M.; Rodrigues, Ceclia M. P.; Castro, Rui E.] Univ Lisbon, Fac Pharm, Res Inst Med iMed ULisboa, Av Prof Gama Pinto, P-1649003 Lisbon, Portugal.
   [Carvalho, Catarina C.; Trindade, Alexandre; Duarte, Antonio] Univ Lisbon, Fac Vet Med, Interdisciplinary Ctr Res Anim Hlth CIISA, Reprod & Dev, Lisbon, Portugal.
   [Trindade, Alexandre; Duarte, Antonio] Gulbenkian Inst Sci, Oeiras, Portugal.
   [Machado, Mariana V.; Cortez-Pinto, Helena] Hosp Santa Maria, Gastrenterol, Lisbon, Portugal.
C3 Universidade de Lisboa; Universidade de Lisboa; Universidade de Lisboa;
   Hospital Santa Maria
RP Castro, RE (corresponding author), Univ Lisbon, Fac Pharm, Res Inst Med iMed ULisboa, Av Prof Gama Pinto, P-1649003 Lisbon, Portugal.
EM ruieduardocastro@ff.ulisboa.pt
RI Trindade, Alexandre/AAC-9726-2019; Castro, Rui/AAG-4179-2021; Borralho,
   Pedro/AAJ-2829-2021; Duarte, Antonio/KFQ-6840-2024; Cortez-Pinto,
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NR 48
TC 81
Z9 89
U1 1
U2 23
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 2041-4889
J9 CELL DEATH DIS
JI Cell Death Dis.
PD APR
PY 2017
VL 8
AR e2748
DI 10.1038/cddis.2017.172
PG 13
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA EU5SK
UT WOS:000401093800008
PM 28406477
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Paulis, L
   Simko, F
   Laudon, M
AF Paulis, Ludovit
   Simko, Fedor
   Laudon, Moshe
TI Cardiovascular effects of melatonin receptor agonists
SO EXPERT OPINION ON INVESTIGATIONAL DRUGS
LA English
DT Review
DE agomelatine; antioxidant; blood pressure; circadin; hypertension;
   melatonin receptor; metabolic syndrome; piromelatine; ramelteon;
   tasimelteon; TIK-301
ID SPONTANEOUSLY HYPERTENSIVE-RATS; PROLONGED-RELEASE MELATONIN; REDUCES
   BLOOD-PRESSURE; ELEVATION MYOCARDIAL-INFARCTION; IMPAIRED NOCTURNAL
   SYNTHESIS; STRESS-INDUCED HYPERTENSION; ISOLATED CORONARY-ARTERIES;
   CONTINUOUS LIGHT EXPOSURE; VASCULAR REACTIVITY; PRIMARY INSOMNIA
AB Introduction: Melatonin synchronizes circadian rhythms with light/dark period and it was demonstrated to correct chronodisruption. Several melatonin receptor agonists with improved pharmacokinetics or increased receptor affinity are being developed, three of them are already in clinical use. However, the actions of melatonin extend beyond chronobiology to cardiovascular and metabolic systems as well. Given the high prevalence of cardiovascular disease and their common occurrence with chronodisruption, it is of utmost importance to classify the cardiometabolic effects of the newly approved and putative melatoninergic drugs.
   Areas covered: In the present review, the available (although very sparse) data on such effects, in particular by the approved (circadin, ramelteon, agomelatine) or clinically advanced (tasimelteon, piromelatine = Neu-P11, TIK-301) compounds are summarized. The authors have searched for an association with blood pressure, vascular reactivity, ischemia, myocardial and vascular remodeling and metabolic syndrome.
   Expert opinion: The data suggest that cardiovascular effects of melatonin are at least partly mediated via MT1/MT2 receptors and associated with its chronobiotic action. Therefore, despite the sparse direct evidence, it is believed that these effects will be shared by melatonin analogs as well. With the expected approval of novel melatoninergic compounds, it is suggested that the investigation of their cardiovascular effects should no longer be neglected.
C1 [Paulis, Ludovit] Comenius Univ, Inst Pathophysiol, Fac Med, Bratislava 81108, Slovakia.
   [Paulis, Ludovit] Comenius Univ, Inst Normal & Pathol Physiol, Bratislava 81108, Slovakia.
   [Paulis, Ludovit] Comenius Univ, Ctr Excellence Regulatory Role Nitr Oxide Civiliz, Bratislava 81108, Slovakia.
   [Paulis, Ludovit; Simko, Fedor] Slovak Acad Sci, Bratislava 81108, Slovakia.
   [Paulis, Ludovit] Charite, Cardiovasc Res Ctr, D-10115 Berlin, Germany.
   [Simko, Fedor] Comenius Univ, Clin Med 3, Fac Med, Bratislava 81108, Slovakia.
   [Simko, Fedor] Comenius Univ, Inst Expt Endocrinol, Bratislava 81108, Slovakia.
   [Laudon, Moshe] Neurim Pharmaceut Ltd, IL-69710 Tel Aviv, Israel.
C3 Comenius University Bratislava; Slovak Academy of Sciences; Institute of
   Normal & Pathological Physiology, SAS; Comenius University Bratislava;
   Comenius University Bratislava; Slovak Academy of Sciences; Berlin
   Institute of Health; Free University of Berlin; Humboldt University of
   Berlin; Charite Universitatsmedizin Berlin; Comenius University
   Bratislava; Comenius University Bratislava
RP Paulis, L (corresponding author), Comenius Univ, Inst Pathophysiol, Fac Med, Sasinkova 4, Bratislava 81108, Slovakia.
EM ludo@lfuk.sk
RI Laudon, Moshe/GXH-1907-2022; Paulis, Ludovit/B-1102-2008
OI Paulis, Ludovit/0000-0003-3834-7395
FU Scientific Grant Agency of the Ministry of Education of the Slovak
   Republic [VEGA 1/0831/11, 1/0227/12, 2/0190/11]; Agency for Science and
   Research Support of the Slovak Republic [APVV-0205-11]
FX Partly supported by grant of Scientific Grant Agency of the Ministry of
   Education of the Slovak Republic, VEGA 1/0831/11, 1/0227/12 and
   2/0190/11 and Agency for Science and Research Support of the Slovak
   Republic, APVV-0205-11.
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NR 136
TC 51
Z9 67
U1 1
U2 44
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1354-3784
EI 1744-7658
J9 EXPERT OPIN INV DRUG
JI Expert Opin. Investig. Drugs
PD NOV
PY 2012
VL 21
IS 11
BP 1661
EP 1678
DI 10.1517/13543784.2012.714771
PG 18
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 022EA
UT WOS:000309937100007
PM 22916799
DA 2025-06-11
ER

PT J
AU Takahashi, Y
   Fukusato, T
AF Takahashi, Yoshihisa
   Fukusato, Toshio
TI Pediatric nonalcoholic fatty liver disease: Overview with emphasis on
   histology
SO WORLD JOURNAL OF GASTROENTEROLOGY
LA English
DT Article
DE Children; Histology; Nonalcoholic fatty liver disease; Nonalcoholic
   steatohepatitis; Obesity
ID PLACEBO-CONTROLLED TRIAL; INSULIN-RESISTANCE; HEPATIC MITOCHONDRIAL;
   URSODEOXYCHOLIC ACID; VITAMIN-E; METABOLIC SYNDROME; OBESE CHILDREN;
   STEATOHEPATITIS; STEATOSIS; METFORMIN
AB Nonalcoholic fatty liver disease (NAFLD) is a disease in which excessive fat accumulates in the liver of a patient without a history of alcohol abuse. This disease includes simple steatosis and nonalcoholic steatohepatitis (NASH). NAFLD/NASH is recognized as a hepatic manifestation of metabolic syndrome. In recent years, pediatric NAFLD has increased in line with the increased prevalence of pediatric obesity. The estimated prevalence of pediatric NAFLD is 2.6%-9.6%, and it is associated with sex, age, and ethnicity. With regard to the pathogenesis of NAFLD, the "two-hit" hypothesis is widely accepted and oxidative stress is thought to play an important role in the second hit. Although clinical symptoms, laboratory data, and imaging findings are important, liver biopsy is regarded as the gold standard for the diagnosis of NAFLD/NASH. In addition, liver biopsy is essential for assessing the degree of necro-inflammatory change and fibrosis in NASH. Two different types of steatohepatitis (type 1 and type 2 NASH) have been reported, with type 2 NASH being present in as many as 51% of pediatric NAFLD patients. However, we and others have observed that type 1 and 2 patterns commonly overlap. Although pharmacotherapy has been studied in clinical trials, lifestyle modification by diet and exercise remains the mainstay of treatment for NAFLD/NASH. (C) 2010 Baishideng. All rights reserved.
C1 [Takahashi, Yoshihisa; Fukusato, Toshio] Teikyo Univ, Dept Pathol, Sch Med, Itabashi Ku, Tokyo 1738605, Japan.
C3 Teikyo University
RP Takahashi, Y (corresponding author), Teikyo Univ, Dept Pathol, Sch Med, Itabashi Ku, 2-11-1 Kaga, Tokyo 1738605, Japan.
EM ytakaha-tky@umin.ac.jp
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NR 61
TC 36
Z9 38
U1 0
U2 7
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 8226 REGENCY DR, PLEASANTON, CA 94588 USA
SN 1007-9327
EI 2219-2840
J9 WORLD J GASTROENTERO
JI World J. Gastroenterol.
PD NOV 14
PY 2010
VL 16
IS 42
BP 5280
EP 5285
DI 10.3748/wjg.v16.i42.5280
PG 6
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 683SB
UT WOS:000284494400003
PM 21072890
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Stewart-Knox, BJ
   Bunting, BP
   Gilpin, S
   Parr, HJ
   Pinhao, S
   Strain, JJ
   de Almeida, MDV
   Gibney, M
AF Stewart-Knox, Barbara J.
   Bunting, Brendan P.
   Gilpin, Sarah
   Parr, Heather J.
   Pinhao, Silvia
   Strain, J. J.
   de Almeida, Maria D. V.
   Gibney, Mike
TI Attitudes toward genetic testing and personalised nutrition in a
   representative sample of European consumers
SO BRITISH JOURNAL OF NUTRITION
LA English
DT Article
DE Personalised nutrition; Nutrigenomics; Consumers; Surveys; Attitudes
ID METABOLIC SYNDROME; HEALTH; ADULTS
AB Negative consumer opinion poses a potential barrier to the application of nutrigenomic intervention. The present study has aimed to determine attitudes toward genetic testing and personalised nutrition among the European public. An omnibus opinion survey of a representative sample aged 14-55 + years (n 5967) took place in France, Italy, Great Britain, Portugal, Poland and Germany during June 2005 as part of the Lipgene project. A majority of respondents (66 %) reported that they would be willing to undergo genetic testing and 27 % to follow a personalised diet. Individuals who indicated a willingness to have a genetic test for the personalising of their diets were more likely to report a history of high blood cholesterol levels, central obesity and/or high levels of stress than those who would have a test only for general interest. Those who indicated that they would not have a genetic test were more likely to be male and less likely to report having central obesity. Individuals with a history of high blood cholesterol were less likely than those who did not to worry if intervention foods contained GM ingredients. Individuals who were aware that they had health problems associated with the metabolic syndrome appeared particularly favourable toward nutrigenomic intervention. These findings are encouraging for the future application of personalised nutrition provided that policies are put in place to address public concern about how genetic information is used and held.
C1 [Stewart-Knox, Barbara J.; Gilpin, Sarah; Parr, Heather J.; Strain, J. J.] Univ Ulster, No Ireland Ctr Food Hlth NICHE, Coleraine BT52 1SA, Londonderry, North Ireland.
   [Bunting, Brendan P.] Univ Ulster, Sch Psychol, Coleraine BT52 1SA, Londonderry, North Ireland.
   [Pinhao, Silvia; de Almeida, Maria D. V.] Univ Porto, P-4100 Oporto, Portugal.
   [Gibney, Mike] Univ Coll Dublin, Dublin 4, Ireland.
C3 Ulster University; Ulster University; Universidade do Porto; University
   College Dublin
RP Stewart-Knox, BJ (corresponding author), Univ Ulster, No Ireland Ctr Food Hlth NICHE, Coleraine BT52 1SA, Londonderry, North Ireland.
EM b.knox@ulster.ac.uk
RI De+Almeida, Maria Daniel/AAE-3343-2022
OI Stewart-Knox, Barbara/0000-0002-6741-3657
FU European Union 6th Framework Food Quality and Safety Programme
   [FOOD-CT2003-505944]
FX The present study was completed on behalf of the Lipgene Consortium and
   ilinded under the European Union 6th Framework Food Quality and Safety
   Programme (code FOOD-CT2003-505944). Survey fieldwork was subcontracted
   to Ipsos MORI (London, IJK). The authors are aware of no personal,
   commercial, political, academic or financial conflict of interest that
   could have influenced the reporting of this research. B. J. S.-K.
   designed the study and wrote the paper. B. P. B. provided statistical
   support. H. J. P. supervised data collection and undertook dala
   analysis. S. G. carried out the preliminary data analysis. S. R
   co-supervised data collection. A D. V. de A. designed and administered
   the project work package. M. G. coordinated the project.
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NR 18
TC 84
Z9 91
U1 0
U2 23
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1145
EI 1475-2662
J9 BRIT J NUTR
JI Br. J. Nutr.
PD APR 14
PY 2009
VL 101
IS 7
BP 982
EP 989
DI 10.1017/S0007114508055657
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nutrition & Dietetics
GA 435JI
UT WOS:000265339800007
PM 18775102
OA Green Submitted, Bronze
DA 2025-06-11
ER

PT J
AU Bawazeer, NM
   Almalki, S
   Alanazi, R
   Alamri, R
   Alanzi, R
   Alhanaya, R
   Alhashem, A
   Aldahash, R
AF Bawazeer, Nahla M.
   Almalki, Sara
   Alanazi, Ruba
   Alamri, Rimaz
   Alanzi, Rana
   Alhanaya, Raghad
   Alhashem, Anwar
   Aldahash, Rehab
TI Examining the Association between Social Media Use and Dietary Habits
   among College Students in Riyadh, Saudi Arabia
SO JOURNAL OF COMMUNITY HEALTH
LA English
DT Article
DE Social media use; Dietary habits; College students; Nutrition; Metabolic
   syndrome
ID IMPACT
AB Food culture plays a vital role in societal dynamics, with various factors influencing dietary choices beyond hunger. Among these factors are external eating, triggered by environmental cues, and emotional eating, which are common stress-coping mechanisms among college students. Social media has a significant impact on nutrition by providing access to food-related content, which can lead to restrictive diets or unhealthy eating habits. High social media engagement is associated with an increased risk of chronic diet-related conditions such as metabolic syndrome. This study investigated the association between social media use and dietary habits among college students in Riyadh, Saudi Arabia. The cross-sectional study surveyed 401 participants online. The findings revealed that 74.6% of participants were women, with a mean age of 20.75 years. A significant portion (51.9%) reported spending over four hours daily on social media, with TikTok, Instagram, and YouTube being the primary sources of nutritional information. Statistical analysis indicated significant differences in dietary scores related to having children, medical conditions, and social media usage time. This study highlights the negative impact of extensive social media use on dietary habits and suggests the need for targeted public health interventions. Recommendations include promoting reliable nutrition-related content on social media, offering affordable healthy food options on campuses, and conducting further research to establish causality between social media use and dietary habits.
C1 [Bawazeer, Nahla M.; Almalki, Sara; Alanazi, Ruba; Alamri, Rimaz; Alanzi, Rana; Alhanaya, Raghad; Alhashem, Anwar; Aldahash, Rehab] Princess Nourah bint Abdulrahman Univ, Coll Hlth & Rehabil Sci, Dept Hlth Sci, POB 84428, Riyadh 11671, Saudi Arabia.
C3 Princess Nourah bint Abdulrahman University
RP Aldahash, R (corresponding author), Princess Nourah bint Abdulrahman Univ, Coll Hlth & Rehabil Sci, Dept Hlth Sci, POB 84428, Riyadh 11671, Saudi Arabia.
EM raaldahash@pnu.edu.sa
RI Aldahash, Rehab/HHZ-8263-2022; Alhashem, Anwar/HKO-0742-2023; BAWAZEER,
   NAHLA/HHR-9891-2022
OI Alhashem, Anwar/0000-0001-9735-0311; Bawazeer, Nahla
   Mohammed/0000-0001-5087-7802
FU Princess Nourah bint Abdulrahman University Researchers Supporting
   Project [PNURSP2024R369]; Princess Nourah bint Abdulrahman University
   Researchers Supporting Project; Princess Nourah bint Abdulrahman
   University, Riyadh, Saudi Arabia
FX We thank all the individuals who contributed to the study. This study
   was supported by the Princess Nourah bint Abdulrahman University
   Researchers Supporting Project (project number: PNURSP2024R369),
   Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia.
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NR 30
TC 0
Z9 0
U1 12
U2 15
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0094-5145
EI 1573-3610
J9 J COMMUN HEALTH
JI J. Community Health
PD APR
PY 2025
VL 50
IS 2
BP 244
EP 251
DI 10.1007/s10900-024-01414-w
EA OCT 2024
PG 8
WC Health Policy & Services; Public, Environmental & Occupational Health
WE Social Science Citation Index (SSCI)
SC Health Care Sciences & Services; Public, Environmental & Occupational
   Health
GA 0NP9R
UT WOS:001336250600003
PM 39427056
DA 2025-06-11
ER

PT J
AU Wong, MS
   Lo, CYJ
   Chen, YL
   Chen, FY
   Kuo, CH
   Chen, JS
   Pei, D
   Pitrone, P
   Wu, CZ
AF Wong, Man Sze
   Lo, Chun Yen Jun
   Chen, Yen-Lin
   Chen, Fang-Yu
   Kuo, Chun-Heng
   Chen, Jin-Shuen
   Pei, Dee
   Pitrone, Pietro
   Wu, Chung-Ze
TI Gamma-Glutamyltransferase Is a Predictor for Future Changes of
   Diabetogenic Factors in Aged Chinese-A Four-Year Follow-Up Study
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Article
DE type 2 diabetes mellitus; gamma-glutamyl transferase; first phase and
   second phase insulin secretion; glucose effectiveness
ID INSULIN-RESISTANCE; GLUCOSE EFFECTIVENESS; OXIDATIVE STRESS; METABOLIC
   SYNDROME; GLUTAMYLTRANSFERASE; ASSOCIATION; SECRETION; RISK; MEN
AB Glucose homeostasis in the body is determined by four diabetes factors (DFs): insulin resistance (IR), glucose effectiveness (GE), and the two phases of insulin secretion-first phase (FPIS) and second phase (SPIS). Previous research points to a correlation between elevated levels of gamma-glutamyl transferase (& gamma;GT) and an increased risk of type 2 diabetes. This study investigates the relationship between & gamma;GT and the four DFs in older Chinese individuals. This study involved 2644 men and 2598 women, all of whom were relatively healthy Chinese individuals aged 60 years or more. The DFs were calculated using formulas developed by our research, based on demographic data and factors related to metabolic syndrome. Pearson's correlation was utilized to assess the relationship between & gamma;GT and the four DFs. The findings suggested a positive correlation between & gamma;GT and IR, FPIS, and SPIS, but a negative correlation with GE in men. Among women, only SPIS and GE were significantly correlated with & gamma;GT. The factors showed varying degrees of correlation, listed in descending order as follows: GE, SPIS, FPIS, and IR. This study confirms a significant correlation between & gamma;GT and DFs in this population, highlighting the noteworthy role of GE.
C1 [Wong, Man Sze; Lo, Chun Yen Jun; Pei, Dee] Fu Jen Catholic Univ, Sch Med, Dept Med, New Taipei City 24352, Taiwan.
   [Chen, Yen-Lin] Triserv Gen Hosp, Natl Def Med Ctr, Dept Pathol, Taipei City 11490, Taiwan.
   [Chen, Fang-Yu; Kuo, Chun-Heng; Pei, Dee] Fu Jen Catholic Univ, Div Endocrinol & Metab, Dept Internal Med, Fu Jen Catholic Univ Hosp,Sch Med,Coll Med, New Taipei City 24352, Taiwan.
   [Chen, Jin-Shuen] Kaohsiung Vet Gen Hosp, Kaohsiung 81362, Taiwan.
   [Chen, Jin-Shuen] Natl Sun Yat Sen Univ, Inst Precis Med, Kaohsiung 80424, Taiwan.
   [Chen, Jin-Shuen] Triserv Gen Hosp, Natl Def Med Ctr, Dept Med, Div Nephrol, Taipei City 11490, Taiwan.
   [Pitrone, Pietro] Papardo Hosp, Radiol Dept, I-98100 Messina, Italy.
   [Wu, Chung-Ze] Taipei Med Univ, Div Endocrinol & Metab, Dept Internal Med, Sch Med,Coll Med, Taipei City 11031, Taiwan.
   [Wu, Chung-Ze] Taipei Med Univ, Shuang Ho Hosp, Dept Internal Med, Div Endocrinol & Metab, New Taipei City 23561, Taiwan.
C3 Fu Jen Catholic University; National Defense Medical Center; Tri-Service
   General Hospital; Fu Jen Catholic University; Fu Jen Catholic University
   Hospital; Kaohsiung Veterans General Hospital; National Sun Yat Sen
   University; National Defense Medical Center; Tri-Service General
   Hospital; Taipei Medical University
RP Wu, CZ (corresponding author), Taipei Med Univ, Div Endocrinol & Metab, Dept Internal Med, Sch Med,Coll Med, Taipei City 11031, Taiwan.; Wu, CZ (corresponding author), Taipei Med Univ, Shuang Ho Hosp, Dept Internal Med, Div Endocrinol & Metab, New Taipei City 23561, Taiwan.
EM mancycat1@gmail.com; junlocy@gmail.com; anthonypatho@gmail.com;
   julia0770@yahoo.com.tw; cpp0103@gmail.com; dgschen@vghks.gov.tw;
   peidee@gmail.com; pieropitrone@live.it; chungze@yahoo.com.tw
RI Kuo, Chun-Heng/AGT-3969-2022; CHEN, JUI-YI/AAV-8854-2021; Wu,
   Changzhi/D-6413-2017; Chen, Yen-Lin/D-8650-2014
OI Wu, Chung-Ze/0000-0001-6118-6070; Wong, Man Sze/0000-0002-1323-7299;
   Pitrone, Pietro/0000-0001-7339-2701; Chen, Yen-Lin/0000-0002-6381-4269
FU All authors acknowledge MJ Health Screening Center, J. T. Tai amp;amp;
   Co. Foundation, and all of the participants.
FX All authors acknowledge MJ Health Screening Center, J. T. Tai & amp; Co.
   Foundation, and all of the participants.
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NR 28
TC 0
Z9 0
U1 1
U2 3
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD SEP
PY 2023
VL 12
IS 17
AR 5606
DI 10.3390/jcm12175606
PG 11
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA Q9MI7
UT WOS:001060681800001
PM 37685672
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Losso, JN
AF Losso, Jack N.
TI The Potential of Dietary Bioactive Compounds against SARS-CoV-2 and
   COVID-19-Induced Endothelial Dysfunction
SO MOLECULES
LA English
DT Review
DE endothelium dysfunction; SARS-CoV-2; COVID-19; functional foods; food
   bioactives
ID GLYCATION END-PRODUCTS; LOW-DENSITY-LIPOPROTEIN; OXIDATIVE STRESS;
   NITRIC-OXIDE; METABOLIC SYNDROME; KAPPA-B; DIABETIC VASCULOPATHY;
   VASCULAR DYSFUNCTION; HEALTHY-SUBJECTS; BRACHIAL-ARTERY
AB COVID-19 is an endothelial disease. All the major comorbidities that increase the risk for severe SARS-CoV-2 infection and severe COVID-19 including old age, obesity, diabetes, hypertension, respiratory disease, compromised immune system, coronary artery disease or heart failure are associated with dysfunctional endothelium. Genetics and environmental factors (epigenetics) are major risk factors for endothelial dysfunction. Individuals with metabolic syndrome are at increased risk for severe SARS-CoV-2 infection and poor COVID-19 outcomes and higher risk of mortality. Old age is a non-modifiable risk factor. All other risk factors are modifiable. This review also identifies dietary risk factors for endothelial dysfunction. Potential dietary preventions that address endothelial dysfunction and its sequelae may have an important role in preventing SARS-CoV-2 infection severity and are key factors for future research to address. This review presents some dietary bioactives with demonstrated efficacy against dysfunctional endothelial cells. This review also covers dietary bioactives with efficacy against SARS-CoV-2 infection. Dietary bioactive compounds that prevent endothelial dysfunction and its sequelae, especially in the gastrointestinal tract, will result in more effective prevention of SARS-CoV-2 variant infection severity and are key factors for future food research to address.
C1 [Losso, Jack N.] Louisiana State Univ, Sch Nutr & Food Sci, Baton Rouge, LA 70803 USA.
C3 Louisiana State University System; Louisiana State University
RP Losso, JN (corresponding author), Louisiana State Univ, Sch Nutr & Food Sci, Baton Rouge, LA 70803 USA.
EM jlosso@agcenter.lsu.edu
OI Losso, Jack/0000-0002-8187-7757
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NR 154
TC 9
Z9 9
U1 0
U2 5
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1420-3049
J9 MOLECULES
JI Molecules
PD MAR
PY 2022
VL 27
IS 5
AR 1623
DI 10.3390/molecules27051623
PG 19
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA ZT9FQ
UT WOS:000769454700001
PM 35268723
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Tzifi, F
   Fretzayas, A
   Chrousos, G
   Kanaka-Gantenbein, C
AF Tzifi, Flora
   Fretzayas, Andreas
   Chrousos, George
   Kanaka-Gantenbein, Christina
TI Non-alcoholic fatty liver infiltration in children: an underdiagnosed
   evolving disease
SO HORMONES-INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM
LA English
DT Review
DE Non-alcoholic fatty liver disease; Obesity; Children
ID LIFE-STYLE INTERVENTION; OBESE CHILDREN; INSULIN-RESISTANCE; HEPATIC
   STEATOSIS; METABOLIC SYNDROME; ETHNIC-DIFFERENCES; OXIDATIVE STRESS;
   SERUM-LEVELS; VITAMIN-E; STEATOHEPATITIS
AB Non-alcoholic fatty liver disease (NAFLD) constitutes the most common liver disease, one that is still underdiagnosed in pediatric populations (as well as in the general population), this due to the progressive increase in childhood obesity observed both in developed and developing countries during the last few decades. The pathophysiology of the disease has not been thoroughly clarified yet. The condition displays common pathways in adults and children; however, there are age-related differences. Unlike adults, children with NAFLD require extensive laboratory analysis, because underlying pathologies other than obesity may contribute to the evolution of the disease. Despite the presence of several serum markers and imaging techniques that contribute to NAFLD diagnosis, liver biopsy remains the gold standard diagnostic procedure. Early intervention and obesity prevention are mandatory, as NAFLD is reversible at an early stage. If left undiagnosed and untreated, NAFLD can progress to steatohepatitis (NASH) and subsequent liver failure, a potentially lethal complication. Of note, there are no treatment options when advanced liver fibrosis occurs. This review summarizes literature data on NAFLD in childhood indicating that this is an evolving disease and a significant component of the metabolic syndrome. Pediatricians should be aware of this entity, screening children at high risk and providing appropriate early management, in collaboration with pediatric subspecialists.
C1 [Tzifi, Flora; Chrousos, George; Kanaka-Gantenbein, Christina] Univ Athens, Aghia Sophia Childrens Hosp, Med Sch, Dept Pediat 1,Div Endocrinol Diabet & Metab, Athens, Greece.
   [Tzifi, Flora; Fretzayas, Andreas] Athens Med Grp, Maroussi, Greece.
C3 National & Kapodistrian University of Athens; The Aghia Sophia
   Children's Hospital
RP Tzifi, F (corresponding author), Univ Athens, Aghia Sophia Childrens Hosp, Med Sch, Dept Pediat 1,Div Endocrinol Diabet & Metab, Athens, Greece.; Tzifi, F (corresponding author), Athens Med Grp, Maroussi, Greece.
EM fltzifi@med.uoa.gr
RI Kanaka-Gantenbein, Christina/AAP-3697-2020; Chrousos, George/G-8702-2011
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NR 123
TC 6
Z9 6
U1 1
U2 6
PU SPRINGER INTERNATIONAL PUBLISHING AG
PI CHAM
PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND
SN 1109-3099
EI 2520-8721
J9 HORM-INT J ENDOCRINO
JI Horm.-Int. J. Endocrinol. Metab.
PD SEP
PY 2019
VL 18
IS 3
BP 255
EP 265
DI 10.1007/s42000-019-00107-7
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA JE8NO
UT WOS:000490947100003
PM 31140156
DA 2025-06-11
ER

PT J
AU Hsueh, WA
   Quiñones, MJ
AF Hsueh, WA
   Quiñones, MJ
TI Role of endothelial dysfunction in insulin resistance
SO AMERICAN JOURNAL OF CARDIOLOGY
LA English
DT Review
ID NITRIC-OXIDE SYNTHASE; CORONARY-HEART-DISEASE; SKELETAL-MUSCLE
   VASODILATION; RENIN-ANGIOTENSIN SYSTEM; C-REACTIVE PROTEIN; DEPENDENT
   VASODILATION; OXIDATIVE STRESS; VASCULAR REACTIVITY; RISK-FACTORS;
   ROSIGLITAZONE TREATMENT
AB The endothelium regulates vascular tone through the release of vasodilating and vasoconstricting substances. The Most important of these vasodilating substances is nitric oxide (NO), which is also vascular-protective and inhibits inflammation, oxidation, vascular smooth muscle cell proliferation, and migration. Damage to the endothelium causes endothelial dysfunction with impaired release of NO and loss of its antiatherogenic protection. Traditional risk factors for coronary artery disease, including diabetes, hypercholesterolemia, hypertension, and low levels, of high-density lipoprotein cholesterol, are associated with endothelial dysfunction and thus promote the atherogenic process. More recently, insulin resistance in the absence of overt diabetes or the metabolic syndrome has been associated with endothelial dysfunction. This association provides evidence that the atherosclerotic process may actually begin earlier in the spectrum of insulin resistance, ultimately resulting in a progression of the metabolic syndrome to prediabetes and then to type 2 diabetes. Aggressive treatment of dyslipidemia and hypertension, even before the onset of type 2 diabetes, would appear prudent in decreasing the progression of the atherosclerotic process. The thiazolidinediones are peroxisome proliferator-activated receptor-gamma agonists that improve glucose and lipid metabolism. These agents have recently been shown to improve endothelial function in the early stages of insulin resistance. Results from ongoing trials with thiazolidinediones will reveal whether they will also reduce cardiovascular end points. (C) 2003 by Excerpta Medica, Inc.
C1 Univ Calif Los Angeles, Sch Med, Div Endocrinol Diabet & Hypertens, Los Angeles, CA 90095 USA.
C3 University of California System; University of California Los Angeles;
   University of California Los Angeles Medical Center; David Geffen School
   of Medicine at UCLA
RP Univ Calif Los Angeles, Sch Med, Div Endocrinol Diabet & Hypertens, 900 Vet Ave,Suite 24-130, Los Angeles, CA 90095 USA.
EM whsueh@mednet.ucla.edu
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NR 105
TC 215
Z9 244
U1 0
U2 9
PU EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
PI BRIDGEWATER
PA 685 ROUTE 202-206 STE 3, BRIDGEWATER, NJ 08807 USA
SN 0002-9149
EI 1879-1913
J9 AM J CARDIOL
JI Am. J. Cardiol.
PD AUG 18
PY 2003
VL 92
IS 4A
BP 10J
EP 17J
DI 10.1016/S0002-9149(03)00611-8
PG 8
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 717NL
UT WOS:000185096000003
PM 12957322
DA 2025-06-11
ER

PT J
AU Miklosz, A
   Nikitiuk, BE
   Chabowski, A
AF Miklosz, Agnieszka
   Nikitiuk, Barbara Emilia
   Chabowski, Adrian
TI Using adipose-derived mesenchymal stem cells to fight the metabolic
   complications of obesity: Where do we stand?
SO OBESITY REVIEWS
LA English
DT Article
DE adipose tissue; ADMSCs; metabolic syndrome; obesity
ID FATTY LIVER-DISEASE; INSULIN-SECRETING CELLS; STROMAL CELLS;
   BONE-MARROW; NONALCOHOLIC STEATOHEPATITIS; HEALTHY OBESITY; HEPATOCYTE
   DIFFERENTIATION; INTERNATIONAL-SOCIETY; REGENERATIVE THERAPY; PROGENITOR
   CELLS
AB Obesity is a critical risk factor for the development of metabolic diseases, and its prevalence is increasing worldwide. Stem cell-based therapies have become a promising tool for therapeutic intervention. Among them are adipose-derived mesenchymal stem cells (ADMSCs), secreting numerous bioactive molecules, like growth factors, cytokines, and chemokines. Their unique features, including immunosuppressive and immunomodulatory properties, make them an ideal candidates for clinical applications. Numerous experimental studies have shown that ADMSCs can improve pancreatic islet cell viability and function, ameliorate hyperglycemia, improve insulin sensitivity, restore liver function, counteract dyslipidemia, lower pro-inflammatory cytokines, and reduce oxidative stress in the animal models. These results prompted scientists to use ADMSCs clinically. However, up to date, there have been few clinical studies or ongoing trails using ADMSCs to treat metabolic disorders such as type 2 diabetes mellitus (T2DM) or liver cirrhosis. Most human studies have implemented autologous ADMSCs with minimal risk of cellular rejection. Because the functionality of ADMSCs is significantly reduced in subjects with obesity and/or metabolic syndrome, their efficacy is questioned. ADMSCs transplantation may offer a potential therapeutic approach for the treatment of metabolic complications of obesity, but randomized controlled trials are required to establish their safety and efficacy in humans prior to routine clinical use.
C1 [Miklosz, Agnieszka; Nikitiuk, Barbara Emilia; Chabowski, Adrian] Med Univ Bialystok, Dept Physiol, Mickiewicza 2C St, PL-15222 Bialystok, Poland.
C3 Medical University of Bialystok
RP Miklosz, A (corresponding author), Med Univ Bialystok, Dept Physiol, Mickiewicza 2C St, PL-15222 Bialystok, Poland.
EM agnieszka.miklosz@umb.edu.pl
RI Miklosz, Agnieszka/S-5208-2018; Chabowski, Adrian/T-2225-2018
OI Miklosz, Agnieszka/0000-0003-4936-3120; Chabowski,
   Adrian/0000-0002-7407-8156; Nikitiuk, Barbara/0000-0002-0768-6944
FU Medical University of Bialystok [SUB/1/DN/20/010/1118]; National Science
   Center [2016/23/D/NZ3/01660]
FX Medical University of Bialystok, Grant/Award Number:
   SUB/1/DN/20/010/1118; National Science Center, Grant/Award Number:
   2016/23/D/NZ3/01660
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NR 151
TC 28
Z9 29
U1 3
U2 17
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1467-7881
EI 1467-789X
J9 OBES REV
JI Obes. Rev.
PD MAY
PY 2022
VL 23
IS 5
DI 10.1111/obr.13413
EA JAN 2022
PG 22
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 0J5GH
UT WOS:000738720700001
PM 34985174
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Sodhi, K
   Srikanthan, K
   Goguet-Rubio, P
   Nichols, A
   Mallick, A
   Nawab, A
   Martin, R
   Shah, PT
   Chaudhry, M
   Sigdel, S
   El-Hamdani, M
   Liu, J
   Xie, ZJ
   Abraham, NG
   Shapiro, JI
AF Sodhi, Komal
   Srikanthan, Krithika
   Goguet-Rubio, Perrine
   Nichols, Alexandra
   Mallick, Amrita
   Nawab, Athar
   Martin, Rebecca
   Shah, Preeya T.
   Chaudhry, Muhammad
   Sigdel, Saroj
   El-Hamdani, Mehiar
   Liu, Jiang
   Xie, Zijian
   Abraham, Nader G.
   Shapiro, Joseph I.
TI RETRACTED: pNaKtide Attenuates Steatohepatitis and Atherosclerosis by
   Blocking Na/K-ATPase/ROS Amplification in C57BI6 and ApoE Knockout Mice
   Fed a Western Diet (Retracted article. See vol. 12, 2022)
SO SCIENTIFIC REPORTS
LA English
DT Article; Retracted Publication
ID FATTY LIVER-DISEASE; METABOLIC SYNDROME; OXIDATIVE STRESS;
   GENE-EXPRESSION; NONALCOHOLIC STEATOHEPATITIS; HEPATIC STEATOSIS;
   ADIPOSE-TISSUE; NA+/K+-ATPASE; PATHOGENESIS; INVOLVEMENT
AB We have previously reported that the alpha 1 subunit of sodium potassium adenosine triphosphatase (Na/K-ATPase), acts as a receptor and an amplifier for reactive oxygen species, in addition to its distinct pumping function. On this background, we speculated that blockade of Na/K-ATPase-induced ROS amplification with a specific peptide, pNaKtide, might attenuate the development of steatohepatitis. To test this hypothesis, pNaKtide was administered to a murine model of NASH: the C57BI6 mouse fed a "western" diet containing high amounts of fat and fructose. The administration of pNaKtide reduced obesity as well as hepatic steatosis, inflammation and fibrosis. Of interest, we also noted marked improvement in mitochondrial fatty acid oxidation, insulin sensitivity, dyslipidemia and aortic streaking in this mouse model. To further elucidate the effects of pNaKtide on atherosclerosis, similar studies were performed in ApoE knockout mice also exposed to the western diet. In these mice, pNaKtide not only improved steatohepatitis, dyslipidemia, and insulin sensitivity, but also ameliorated significant aortic atherosclerosis. Collectively, this study demonstrates that the Na/K-ATPase/ROS amplification loop contributes significantly to the development and progression of steatohepatitis and atherosclerosis. And furthermore, this study presents a potential treatment, the pNaKtide, for the metabolic syndrome phenotype.
C1 [Sodhi, Komal; Srikanthan, Krithika; Goguet-Rubio, Perrine; Nichols, Alexandra; Mallick, Amrita; Nawab, Athar; Martin, Rebecca; Shah, Preeya T.; Chaudhry, Muhammad; Sigdel, Saroj; El-Hamdani, Mehiar; Liu, Jiang; Xie, Zijian; Abraham, Nader G.; Shapiro, Joseph I.] Marshall Univ, Joan C Edwards Sch Med, Dept Med, Huntington, WV USA.
   [Sodhi, Komal; Srikanthan, Krithika; Goguet-Rubio, Perrine; Nichols, Alexandra; Mallick, Amrita; Nawab, Athar; Martin, Rebecca; Shah, Preeya T.; Chaudhry, Muhammad; Sigdel, Saroj; El-Hamdani, Mehiar; Liu, Jiang; Xie, Zijian; Abraham, Nader G.; Shapiro, Joseph I.] Marshall Univ, Joan C Edwards Sch Med, Dept Surg, Huntington, WV USA.
   [Sodhi, Komal; Srikanthan, Krithika; Goguet-Rubio, Perrine; Nichols, Alexandra; Mallick, Amrita; Nawab, Athar; Martin, Rebecca; Shah, Preeya T.; Chaudhry, Muhammad; Sigdel, Saroj; El-Hamdani, Mehiar; Liu, Jiang; Xie, Zijian; Abraham, Nader G.; Shapiro, Joseph I.] Marshall Univ, Joan C Edwards Sch Med, Dept Pathol, Huntington, WV USA.
   [Sodhi, Komal; Srikanthan, Krithika; Goguet-Rubio, Perrine; Nichols, Alexandra; Mallick, Amrita; Nawab, Athar; Martin, Rebecca; Shah, Preeya T.; Chaudhry, Muhammad; Sigdel, Saroj; El-Hamdani, Mehiar; Liu, Jiang; Xie, Zijian; Abraham, Nader G.; Shapiro, Joseph I.] Marshall Univ, Joan C Edwards Sch Med, Dept Cardiol, Huntington, WV USA.
   [Abraham, Nader G.] New York Med Coll, Dept Med, Valhalla, NY 10595 USA.
C3 Marshall University; Marshall University; Marshall University; Marshall
   University; New York Medical College
RP Shapiro, JI (corresponding author), Marshall Univ, Joan C Edwards Sch Med, Dept Med, Huntington, WV USA.; Shapiro, JI (corresponding author), Marshall Univ, Joan C Edwards Sch Med, Dept Surg, Huntington, WV USA.; Shapiro, JI (corresponding author), Marshall Univ, Joan C Edwards Sch Med, Dept Pathol, Huntington, WV USA.; Shapiro, JI (corresponding author), Marshall Univ, Joan C Edwards Sch Med, Dept Cardiol, Huntington, WV USA.
EM shapiroj@marshall.edu
FU National Institutes of Health [HL109015, HL071556, HL105649, HL55601,
   HL34300]; Brickstreet Foundation; Huntington Foundation, Inc.
FX This work was supported by National Institutes of Health Grants HL109015
   (to J.I.S. and Z.X.), HL071556 and HL105649 (to J.I.S.), and HL55601 and
   HL34300 (to N.G.A.), by the Brickstreet Foundation (to J.I.S. and
   N.G.A.) and by the Huntington Foundation, Inc.
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NR 58
TC 35
Z9 42
U1 0
U2 10
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD MAR 15
PY 2017
VL 7
AR 193
DI 10.1038/s41598-017-00306-5
PG 14
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA EO7KR
UT WOS:000396870100003
PM 28298638
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Calvo-Ochoa, E
   Arias, C
AF Calvo-Ochoa, Erika
   Arias, Clorinda
TI Cellular and metabolic alterations in the hippocampus caused by insulin
   signalling dysfunction and its association with cognitive impairment
   during aging and Alzheimer's disease: studies in animal models
SO DIABETES-METABOLISM RESEARCH AND REVIEWS
LA English
DT Review
DE insulin resistance; diabetes; hippocampal dysfunction; Alzheimer's
   disease; cognitive decline; obesity
ID CENTRAL-NERVOUS-SYSTEM; BETA-AMYLOID NEUROTOXICITY; GROWTH-FACTOR
   EXPRESSION; GLUCOSE-TOLERANCE STATUS; LONG-TERM POTENTIATION; OBESE
   ZUCKER RATS; HIGH-FAT DIETS; SYNAPTIC PLASTICITY; INTRANASAL INSULIN;
   OXIDATIVE STRESS
AB A growing body of animal and epidemiological studies suggest that metabolic diseases such as obesity, insulin resistance, metabolic syndrome and type 2 diabetes mellitus are associated with the development of cognitive impairment, dementia and Alzheimer's disease, particularly in aging. Several lines of evidence suggest that insulin signalling dysfunction produces these metabolic alterations and underlie the development of these neurodegenerative diseases. In this article, we address normal insulin function in the synapse; we review and discuss the physiopathological hallmarks of synaptic insulin signalling dysfunction associated with metabolic alterations. Additionally, we describe and review the major animal models of obesity, insulin resistance, metabolic syndrome and type 2 diabetes mellitus. The comprehensive knowledge of the molecular mechanisms behind the association of metabolic alterations and cognitive impairment could facilitate the early detection of neurodegenerative diseases in patients with metabolic alterations, with treatment that focus on neuroprotection. It could also help in the development of metabolic-based therapies and drugs for using in dementia and Alzheimer's disease patients to alleviate their symptoms in a more efficient and comprehensive way. Copyright (c) 2014 John Wiley & Sons, Ltd.
C1 [Calvo-Ochoa, Erika; Arias, Clorinda] Univ Nacl Autonoma Mexico, Inst Invest Biomed, Dept Med Genom & Toxicol Ambiental, Mexico City 04510, DF, Mexico.
C3 Universidad Nacional Autonoma de Mexico
RP Arias, C (corresponding author), Univ Nacl Autonoma Mexico, Inst Invest Biomed, Dept Med Genom & Toxicol Ambiental, AP 70-228, Mexico City 04510, DF, Mexico.
EM carias@servidor.unam.mx
RI Calvo-Ochoa, Erika/AAN-1150-2020
OI Calvo-Ochoa, Erika/0000-0002-4363-3962
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NR 164
TC 67
Z9 71
U1 0
U2 29
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1520-7552
EI 1520-7560
J9 DIABETES-METAB RES
JI Diabetes-Metab. Res. Rev.
PD JAN
PY 2015
VL 31
IS 1
BP 1
EP 13
DI 10.1002/dmrr.2531
PG 13
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA AY9SC
UT WOS:000347889600001
PM 24464982
DA 2025-06-11
ER

PT J
AU Midei, AJ
   Matthews, KA
AF Midei, Aimee J.
   Matthews, Karen A.
TI Social Relationships and Negative Emotional Traits Are Associated With
   Central Adiposity and Arterial Stiffness in Healthy Adolescents
SO HEALTH PSYCHOLOGY
LA English
DT Article
DE central adiposity; arterial stiffness; social relationships; negative
   emotional traits; adolescents
ID PULSE-WAVE VELOCITY; CARDIOVASCULAR RISK-FACTORS; BODY-FAT DISTRIBUTION;
   AMBULATORY BLOOD-PRESSURE; TO-HIP RATIO; METABOLIC SYNDROME;
   OLDER-ADULTS; HYPERTENSIVE PATIENTS; POSTMENOPAUSAL WOMEN; PSYCHOSOCIAL
   FACTORS
AB Objective: We examined the role of social relationships and negative emotional traits in the development of central adiposity and arterial stiffness in healthy adolescents. Design: A prospective, longitudinal study examined 213 Black and White adolescents (50% Black, 51% female); 160 returned for a second assessment approximately 3 years later. Main Outcome Measures: Psychosocial variables at both assessments were measured with the Measurement of Attachment Qualities (Carver, 1997), Social Relationships Index (study entry only; Uchino, Holt-Lunstad, Uno, & Flinders, 2001), Spielberger Trait Anger and Anxiety (Spielberger et al., 1979), and the Cook-Medley Hostility Scale (Cook & Medley, 1954). Central adiposity was assessed by waist-to-hip ratio (WHR) at both assessments and arterial stiffness by pulse wave velocity (PWV) at the second assessment only. Results: Linear regression models controlled for demographic variables and body mass index showed that adolescents with less Supportive Relationships (beta = -.121, p = .05) and higher Trait Anger (beta = .117, p = .05) had increased WHR over time, adjusted for initial WHR. Those with higher Attachment Anxiety (beta = .211, p = .01) and Total Hostility (beta = .234, p < .01) had greater PWV. Psychosocial associations for PWV were more apparent among Blacks. Conclusion: Psychosocial variables may be important in the development of central adiposity and arterial stiffness in adolescence.
C1 [Matthews, Karen A.] Univ Pittsburgh, Dept Psychiat, Pittsburgh, PA 15213 USA.
   [Midei, Aimee J.] Univ Pittsburgh, Dept Psychol, Pittsburgh, PA 15260 USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE); University
   of Pittsburgh; Pennsylvania Commonwealth System of Higher Education
   (PCSHE); University of Pittsburgh
RP Matthews, KA (corresponding author), Univ Pittsburgh, Dept Psychiat, 3811 Ohara St, Pittsburgh, PA 15213 USA.
EM matthewska@upmc.edu
FU NIH [HL25767, T32 HL007560]
FX This research was supported by NIH HL25767 and T32 HL007560. We thank
   Diana Buck and Karen Kenyon for their dedicated work on this study, and
   Rebecca Thurston for her helpful comments on an earlier version of this
   article.
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NR 55
TC 53
Z9 61
U1 1
U2 15
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 0278-6133
EI 1930-7810
J9 HEALTH PSYCHOL
JI Health Psychol.
PD MAY
PY 2009
VL 28
IS 3
BP 347
EP 353
DI 10.1037/a0014214
PG 7
WC Psychology, Clinical; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology
GA 445XM
UT WOS:000266084800011
PM 19450041
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Zhu, WF
   Zhou, Y
   Tsao, R
   Dong, HH
   Zhang, H
AF Zhu, Weifeng
   Zhou, Ying
   Tsao, Rong
   Dong, Huanhuan
   Zhang, Hua
TI Amelioratory Effect of Resistant Starch on Non-alcoholic Fatty Liver
   Disease via the Gut-Liver Axis
SO FRONTIERS IN NUTRITION
LA English
DT Review
DE resistant starch; NAFLD; gut-liver axis; gut microbiota; gut metabolites
ID OXIDATIVE STRESS; POTENTIAL ROLE; DIET; ACID; MICROBIOTA; BARRIER;
   NAFLD; RECEPTOR; BUTYRATE; BRAIN
AB Non-alcoholic fatty liver disease (NAFLD) is a hepatic manifestation of metabolic syndrome with a global prevalence. Impaired gut barrier function caused by an unhealthy diet plays a key role in disrupting the immune-metabolic homeostasis of the gut-liver axis (GLA), leading to NAFLD. Therefore, dietary interventions have been studied as feasible alternative therapeutic approaches to ameliorate NAFLD. Resistant starches (RSs) are prebiotics that reduce systemic inflammation in patients with metabolic syndrome. The present review aimed to elucidate the mechanisms of the GLA in alleviating NAFLD and provide insights into how dietary RSs counteract diet-induced inflammation in the GLA. Emerging evidence suggests that RS intake alters gut microbiota structure, enhances mucosal immune tolerance, and promotes the production of microbial metabolites such as short-chain fatty acids (SCFAs) and secondary bile acids. These metabolites directly stimulate the growth of intestinal epithelial cells and elicit GPR41/GPR43, FXR, and TGR5 signaling cascades to sustain immune-metabolic homeostasis in the GLA. The literature also revealed the dietary-immune-metabolic interplay by which RSs exert their regulatory effect on the immune-metabolic crosstalk of the GLA and the related molecular basis, suggesting that dietary intervention with RSs may be a promising alternative therapeutic strategy against diet-induced dysfunction of the GLA and, ultimately, the risk of developing NAFLD.
C1 [Zhu, Weifeng; Zhou, Ying; Dong, Huanhuan; Zhang, Hua] Jiangxi Univ Tradit Chinese Med, Coll Pharm, Dept Food Nutr & Safety, Nanchang, Peoples R China.
   [Tsao, Rong] Agr & Agrifood Canada, Guelph Res & Dev Ctr, Guelph, ON, Canada.
C3 Jiangxi University of Traditional Chinese Medicine; Agriculture & Agri
   Food Canada
RP Dong, HH; Zhang, H (corresponding author), Jiangxi Univ Tradit Chinese Med, Coll Pharm, Dept Food Nutr & Safety, Nanchang, Peoples R China.
EM donghh@jxutcm.edu.cn; 20191002@jxutcm.edu.cn
RI Tsao, Rong/I-3096-2014
FU National Key R&D Program Key Special Project, China [2019YFC1604905];
   Jiangxi Provincial Thousand Talents Plan Project [jxsq2019101023];
   Natural Science Foundation of Jiangxi Province [20202BABL205011]
FX Funding This research was supported by the National Key R&D Program Key
   Special Project, China (Grant no. 2019YFC1604905), Jiangxi Provincial
   Thousand Talents Plan Project (Grant no. jxsq2019101023), and Natural
   Science Foundation of Jiangxi Province (Grant No. 20202BABL205011).
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NR 103
TC 13
Z9 14
U1 10
U2 71
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD MAY 17
PY 2022
VL 9
AR 861854
DI 10.3389/fnut.2022.861854
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 1T9PM
UT WOS:000805055500001
PM 35662935
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Mekala, N
   Kurdys, J
   Vicenzi, AP
   Weiler, LR
   Avramut, C
   Vazquez, EJ
   Ragina, N
   Rosca, MG
AF Mekala, Naveen
   Kurdys, Jacob
   Vicenzi, Alexis Paige
   Weiler, Leana Rose
   Avramut, Carmen
   Vazquez, Edwin J.
   Ragina, Neli
   Rosca, Mariana G.
TI MiR 208a Regulates Mitochondrial Biogenesis in Metabolically Challenged
   Cardiomyocytes
SO CELLS
LA English
DT Article
DE cardiomyocytes; metabolic syndrome; miR 208a; mitochondrial biogenesis;
   bioenergetics
ID FATTY-ACID OXIDATION; DIASTOLIC DYSFUNCTION; DIABETIC CARDIOMYOPATHY;
   HEART-FAILURE; MICRORNAS; BETA; PHOSPHORYLATION; HYPERTROPHY;
   PGC-1-ALPHA; INHIBITION
AB Metabolic syndrome increases the risk for cardiovascular disease including metabolic cardiomyopathy that may progress to heart failure. The decline in mitochondrial metabolism is considered a critical pathogenic mechanism that drives this progression. Considering its cardiac specificity, we hypothesized that miR 208a regulates the bioenergetic metabolism in human cardiomyocytes exposed to metabolic challenges. We screened in silico for potential miR 208a targets focusing on mitochondrial outcomes, and we found that mRNA species for mediator complex subunit 7, mitochondrial ribosomal protein 28, stanniocalcin 1, and Sortin nexin 10 are rescued by the CRISPR deletion of miR 208a in human SV40 cardiomyocytes exposed to metabolic challenges (high glucose and high albumin-bound palmitate). These mRNAs translate into proteins that are involved in nuclear transcription, mitochondrial translation, mitochondrial integrity, and protein trafficking. MiR 208a suppression prevented the decrease in myosin heavy chain alpha isoform induced by the metabolic stress suggesting protection against a decrease in cardiac contractility. MiR 208a deficiency opposed the decrease in the mitochondrial biogenesis signaling pathway, mtDNA, mitochondrial markers, and respiratory properties induced by metabolic challenges. The benefit of miR 208a suppression on mitochondrial function was canceled by the reinsertion of miR 208a. In summary, miR 208a regulates mitochondrial biogenesis and function in cardiomyocytes exposed to diabetic conditions. MiR 208a may be a therapeutic target to promote mitochondrial biogenesis in chronic diseases associated with mitochondrial defects.
C1 [Mekala, Naveen; Kurdys, Jacob; Vicenzi, Alexis Paige; Weiler, Leana Rose; Avramut, Carmen; Vazquez, Edwin J.; Ragina, Neli; Rosca, Mariana G.] Cent Michigan Univ, Coll Med, Dept Fdn Sci, Mt Pleasant, MI 48858 USA.
   [Mekala, Naveen] Temple Univ, Lewis Katz Sch Med, Philadelphia, PA 19122 USA.
   [Vazquez, Edwin J.] Int Univ Hlth Sci, Sch Med, St Kitts, WI USA.
C3 Central Michigan University; Pennsylvania Commonwealth System of Higher
   Education (PCSHE); Temple University
RP Rosca, MG (corresponding author), Cent Michigan Univ, Coll Med, Dept Fdn Sci, Mt Pleasant, MI 48858 USA.
EM naveen.mekala@temple.edu; kurdysj@gmail.com; vicen1ap@cmich.edu;
   weile11r@cmich.edu; avram1c@cmich.edu; edwinjvazquez@gmail.com;
   ragin1n@cmich.edu; rosca1g@cmich.edu
RI Rosca, Mariana/ABH-7847-2020; Mekala, Naveen/AGN-0107-2022
OI Rosca, Mariana/0000-0003-3605-9787
FU Central Michigan University College of Medicine; American Heart
   Association [18AIREA33990023]; American Heart Association (AHA)
   [18AIREA33990023] Funding Source: American Heart Association (AHA)
FX This work was supported by the Central Michigan University College of
   Medicine and the American Heart Association (AHA Institutional Research
   Enhancement Award, 18AIREA33990023).
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NR 47
TC 6
Z9 8
U1 0
U2 6
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2073-4409
J9 CELLS-BASEL
JI Cells
PD NOV
PY 2021
VL 10
IS 11
AR 3152
DI 10.3390/cells10113152
PG 20
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA XG7MO
UT WOS:000724933300001
PM 34831374
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Panickar, KS
AF Panickar, Kiran S.
TI Effects of dietary polyphenols on neuroregulatory factors and pathways
   that mediate food intake and energy regulation in obesity
SO MOLECULAR NUTRITION & FOOD RESEARCH
LA English
DT Review
DE Hypothalamus; Metabolic syndrome; Neuropeptides; Nutrition
ID ISLET AMYLOID POLYPEPTIDE; CENTRAL-NERVOUS-SYSTEM; MELANIN-CONCENTRATING
   HORMONE; BODY-WEIGHT REGULATION; PULP PREPARATION RICH; GRAPE SEED
   EXTRACT; NEUROPEPTIDE-Y; INSULIN-RESISTANCE; OXIDATIVE STRESS;
   ADIPOSE-TISSUE
AB Polyphenols are natural substances and are enriched in vegetables, fruits, grains, bark, tea, and wine. Some polyphenols have insulin-potentiating and anti-inflammatory effects, both of which are important in obesity. Dietary supplementation with polyphenolic compounds is associated with reduced diet-induced obesity and/or metabolic syndrome in animal and human studies. Insights into mechanisms that regulate food intake and satiety have led to an increased understanding of obesity but the pathogenesis underlying obesity is lacking. Food intake is subject to a complex regulation by the hypothalamus and other brain centers including the brain stem and the hippocampus. An intricate network of interacting feedback mechanisms that involve the aforementioned neural centers along with the stomach, gut, liver, thyroid, and adipose tissue in the periphery, influence the eventual outcome of food intake and satiety. Key peripheral signals, such as leptin, insulin, and ghrelin, have been linked to hypothalamic neuropeptide systems in energy regulation. This review will examine the neural centers important in food intake, the role of various neuropeptides, and the neurohormonal influence on food intake. The potential role of polyphenols in influencing the neuroregulatory factors, the neural signaling pathways and/or the peripheral feedback mechanisms that modulate food intake will also be examined.
C1 [Panickar, Kiran S.] ARS, Diet Genom & Immunol Lab, Beltsville Human Nutr Res Ctr, USDA, Beltsville, MD 20705 USA.
   [Panickar, Kiran S.] Univ Maryland, Sch Med, Dept Pediat, Baltimore, MD 21201 USA.
C3 United States Department of Agriculture (USDA); University System of
   Maryland; University of Maryland Baltimore
RP Panickar, KS (corresponding author), ARS, Diet Genom & Immunol Lab, Beltsville Human Nutr Res Ctr, USDA, 10300 Baltimore Ave,Bldg 307C, Beltsville, MD 20705 USA.
EM kiran.panickar@ars.usda.gov
FU Beltsville Human Nutrition Research Center, United States Department of
   Agriculture; University of Maryland School of Medicine, Baltimore, MD;
   Integrity Nutraceuticals (Spring Hill, TN, USA)
FX Supported in part by a Beltsville Human Nutrition Research Center,
   United States Department of Agriculture-initiated CRADA with the
   University of Maryland School of Medicine, Baltimore, MD.The author has
   declared no conflict of interest. Author collaborates with scientists
   who have funding from Integrity Nutraceuticals (Spring Hill, TN, USA)
   and a trust agreement with Tang-An Nutritional Health Care Products,
   Beijing, China.
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NR 170
TC 85
Z9 89
U1 1
U2 111
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1613-4125
EI 1613-4133
J9 MOL NUTR FOOD RES
JI Mol. Nutr. Food Res.
PD JAN
PY 2013
VL 57
IS 1
BP 34
EP 47
DI 10.1002/mnfr.201200431
PG 14
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA 065CH
UT WOS:000313124600004
PM 23125162
DA 2025-06-11
ER

PT J
AU Fujita, K
   Wada, K
   Nozaki, Y
   Yoneda, M
   Endo, H
   Takahashi, H
   Kirikoshi, H
   Inamori, M
   Kobayashi, N
   Kubota, K
   Saito, S
   Nakajima, A
AF Fujita, Koji
   Wada, Koichiro
   Nozaki, Yuichi
   Yoneda, Masato
   Endo, Hiroki
   Takahashi, Hirokazu
   Kirikoshi, Hiroyuki
   Inamori, Masahiko
   Kobayashi, Noritoshi
   Kubota, Kensuke
   Saito, Satoru
   Nakajima, Atsushi
TI Serum nitric oxide metabolite as a biomarker of visceral fat
   accumulation: Clinical significance of measurement for nitrate/nitrite
SO MEDICAL SCIENCE MONITOR
LA English
DT Article
DE visceral fat; obesity; NO metabolite; waist scale; metabolic syndrome
ID CARDIOVASCULAR RISK-FACTORS; BODY-MASS INDEX; ADIPOSE-TISSUE; WAIST
   CIRCUMFERENCE; DIABETES-MELLITUS; OXIDATIVE STRESS; DIFFERENTIATION;
   ADIPOCYTES; OVERWEIGHT; DIAGNOSIS
AB Background: A visceral fat area of more than 100 cm(2) as measured by computed tomography (CT) at the umbilical level has been included as a criterion for obesity in all the proposed criteria for metabolic syndrome. However, CT cannot be used frequently because of radiation exposure. We evaluated the usefulness of measurement of the serum levels of nitric oxide (NO), instead of CT and the waist circumference, as a marker of abdominal visceral fat accumulation.
   Material/Methods: The study was carried out in 80 subjects. The serum levels of NO metabolites (nitrate/nitrite) were measured using the Griess reagent.
   Results: Simple and multiple regression analysis revealed that the serum levels of NO metabolites showed the greatest degree of correlation with the visceral fat area (r = 0.743, p < 0.0001), and corresponded to a visceral fat area of 100 cm(2), as determined using the ROC curve, was 21.0 mu mol/ml (sensitivity 88%, specificity 82%); this method was more sensitive than the waist circumference for evaluation of the visceral fat accumulation.
   Conclusions: Measurement of the serum levels of NO metabolites may be a simple, safe, convenient and reliable method for the evaluation of visceral fat accumulation in clinical diagnostic screening.
C1 [Fujita, Koji; Nozaki, Yuichi; Yoneda, Masato; Endo, Hiroki; Takahashi, Hirokazu; Kirikoshi, Hiroyuki; Inamori, Masahiko; Kobayashi, Noritoshi; Kubota, Kensuke; Saito, Satoru; Nakajima, Atsushi] Yokohama City Univ, Grad Sch Med, Div Gastroenterol, Kanazawa Ku, Yokohama, Kanagawa 2360004, Japan.
   [Wada, Koichiro] Osaka Univ, Dept Pharmacol, Grad Sch Dent, Osaka, Japan.
C3 Yokohama City University; The University of Osaka
RP Fujita, K (corresponding author), Yokohama City Univ, Grad Sch Med, Div Gastroenterol, Kanazawa Ku, 3-9 Fuku Ura, Yokohama, Kanagawa 2360004, Japan.
EM kfujita@yokohama-cu.ac.jp
RI Endo, Hiroki/KYQ-2798-2024; Kubota, Kensuke/KHU-2451-2024
FU Ministry of Health, Labor and Welfare of Japan; Ministry of Education,
   Culture, Sports, Science and Technology of Japan Kiban-B; National
   Institute of Biomedical Innovation
FX Supported in part by a Grant-in-aid from the Ministry of Health, Labor
   and Welfare of Japan to AN; by a grant from the Ministry of Education,
   Culture, Sports, Science and Technology of Japan Kiban-B to AN; and by a
   grant from the National Institute of Biomedical Innovation to AN. This
   study was not supported by private funding
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NR 53
TC 16
Z9 17
U1 0
U2 5
PU INT SCIENTIFIC INFORMATION, INC
PI MELVILLE
PA 150 BROADHOLLOW RD, STE 114, MELVILLE, NY 11747 USA
EI 1643-3750
J9 MED SCI MONITOR
JI Med. Sci. Monitor
PD MAR
PY 2011
VL 17
IS 3
BP CR123
EP CR131
DI 10.12659/MSM.881445
PG 9
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 734MH
UT WOS:000288337700005
PM 21358598
OA Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Chen, LX
   He, XW
   Tao, TT
   Chen, LK
   Chen, Y
   Mao, LQ
   Liu, P
AF Chen, Linxi
   He, Xinwei
   Tao, Taotao
   Chen, Linkao
   Chen, Yun
   Mao, Lingqun
   Liu, Peng
TI Association between metabolic syndrome components and impulse control
   disorders in Parkinson's disease
SO FRONTIERS IN NEUROSCIENCE
LA English
DT Article
DE Parkinson's disease; impulse control disorders (ICDs); compulsive
   eating; HbA1c; diabetes mellitus
ID DEPRESSION; PRAMIPEXOLE; FEATURES; SCALE
AB BackgroundCurrent evidence on management of impulse control disorders (ICDs) in Parkinson's disease (PD) remains scarce, and exploring modifiable risk factors is crucial. ObjectiveWe evaluated the profiles of ICDs in PD patients and aimed to determine the associations between ICDs, metabolic syndrome components and other clinical features. MethodsWe enrolled patients diagnosed with PD in this study and conducted comprehensive clinical assessments. ResultsWe recruited 39 PD patients with ICDs and 66 PD patients without ICDs. Out of the 39 patients with ICDs, 19 (48.7%) had one impulse control disorder, while 20 (51.3%) had two or more. The most commonly reported symptom of ICDs was compulsive eating (48.7%). Significant differences were observed between the PD patients with and without ICDs in terms of their HbA1c levels, history of diabetes mellitus, dopamine agonist use, levodopa equivalent dose of dopamine agonists (LED DA), and Hamilton Depression Rating Scale (HAMD) scores. HbA1c levels were significantly higher in the PD patients with compulsive eating. Stepwise logistic regression analyses were performed with the dependent variables of ICDs (yes/no) and compulsive eating (yes/no). Among the 105 PD patients, those with ICDs exhibited higher levels of HbA1c, HAMD score and LED DA than those without ICDs (p < 0.01). Among 39 PD patients with ICDs, those with compulsive eating exhibited higher levels of HbA1c (OR = 2.148, 95% CI = 1.004-4.594, p < 0.05). Among 105 PD patients, those with compulsive eating exhibited higher levels of HbA1c, LED DA and HAMD score (p < 0.05). ConclusionThis study provides insights into the profiles of ICDs in PD patients and their associations with various clinical features. Compulsive eating was the most common ICDs symptom reported. Notably, HbA1c levels were found to be higher in patients with compulsive eating, indicating that poor blood glucose control may be a potential risk factor for ICDs in PD. However, it should be noted that the higher HbA1c levels could also be a consequence of compulsive eating rather than a causal factor for ICDs in PD. Further research is needed to confirm the modifiable risk factors for ICDs in PD.
C1 [Chen, Linxi; He, Xinwei; Tao, Taotao; Chen, Linkao; Chen, Yun; Mao, Lingqun; Liu, Peng] Taizhou Univ Hosp, Taizhou Cent Hosp, Dept Neurol, Taizhou, Peoples R China.
   [Chen, Linxi] Taizhou Univ Hosp, Taizhou Cent Hosp, Dept Pathol, Taizhou, Peoples R China.
C3 Taizhou University; Taizhou University
RP Mao, LQ; Liu, P (corresponding author), Taizhou Univ Hosp, Taizhou Cent Hosp, Dept Neurol, Taizhou, Peoples R China.
EM maolq@tzzxyy.com; liup0487@tzzxyy.com
RI He, Xinwei/AGR-7145-2022
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NR 25
TC 1
Z9 1
U1 0
U2 2
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1662-453X
J9 FRONT NEUROSCI-SWITZ
JI Front. Neurosci.
PD MAY 18
PY 2023
VL 17
AR 1191338
DI 10.3389/fnins.2023.1191338
PG 7
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA H7UN8
UT WOS:000997970300001
PM 37274186
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Kong, FJ
   Ma, LL
   Guo, JJ
   Xu, LH
   Li, Y
   Qu, S
AF Kong, Fei-Juan
   Ma, Lei-Lei
   Guo, Jun-Jie
   Xu, Lin-Hao
   Li, Yun
   Qu, Shen
TI Endoplasmic reticulum stress/autophagy pathway is involved in
   diabetes-induced neuronal apoptosis and cognitive decline in mice
SO CLINICAL SCIENCE
LA English
DT Article
ID LONG-TERM POTENTIATION; SYNAPTIC PLASTICITY; ALZHEIMERS-DISEASE;
   METABOLIC SYNDROME; STRESS; AUTOPHAGY; IMPACT; BRAIN; IMPAIRMENT;
   MELLITUS
AB Diabetes mellitus is a significant global public health problem depicting a rising prevalence worldwide. As a serious complication of diabetes, diabetes-associated cognitive decline is attracting increasing attention. However, the underlying mechanisms are yet to be fully determined. Both endoplasmic reticulum (ER) stress and autophagy have been reported to modulate neuronal survival and death and be associated with several neurodegenerative diseases. Here, a streptozotocin-induced diabetic mouse model and primary cultured mouse hippocampal neurons were employed to investigate the possible role of ER stress and autophagy in diabetes-induced neuronal apoptosis and cognitive impairments, and further explore the potentialmolecular mechanisms. ER stress markers GRP78 and CHOPwere both enhanced in diabetic mice, as was phosphorylation of PERK, IRE1 alpha, and JNK. In addition, the results indicated an elevated level of autophagy in diabetic mice, as demonstrated by up-regulated expressions of autophagy markers LC3-II, beclin 1 and down-regulated level of p62, and increased formation of autophagic vacuoles and LC3-II aggregates. Meanwhile, we found that these effects could be abolished by ER stress inhibitor 4-phenylbutyrate or JNK inhibitor SP600125 in vitro. Furthermore, neuronal apoptosis of diabetic mice was attenuated by pretreatment with 4-phenylbutyrate, while aggravated by application of inhibitor of autophagy bafilomycin A1 in vitro. These results suggest that ER stress pathway may be involved in diabetes-mediated neurotoxicity and promote the following cognitive impairments. More important, autophagy was induced by diabetes possibly through ER stress-mediated JNK pathway, which may protect neurons against ER stress-associated cell damages.
C1 [Kong, Fei-Juan; Qu, Shen] Tongji Univ, Shanghai Peoples Hosp 10, Sch Med, Dept Endocrinol & Metab, Shanghai, Peoples R China.
   [Ma, Lei-Lei] Zhejiang Prov Peoples Hosp, Dept Crit Care Med, Hangzhou, Zhejiang, Peoples R China.
   [Ma, Lei-Lei] Peoples Hosp Hangzhou, Med Coll, Hangzhou, Zhejiang, Peoples R China.
   [Ma, Lei-Lei; Guo, Jun-Jie] Qingdao Univ, Affiliated Hosp, Dept Cardiol, Qingdao, Peoples R China.
   [Ma, Lei-Lei] Fudan Univ, Zhongshan Hosp, Shanghai Inst Cardiovasc Dis, Shanghai, Peoples R China.
   [Xu, Lin-Hao] Hangzhou Med Coll, Fac Basic Med, Dept Anat, Hangzhou, Zhejiang, Peoples R China.
   [Li, Yun] Nanchang Univ, Affiliated Hosp 2, Dept Ophthalmol, Nanchang, Jiangxi, Peoples R China.
C3 Tongji University; Hangzhou Medical College; Zhejiang Provincial
   People's Hospital; Qingdao University; Fudan University; Hangzhou
   Medical College; Nanchang University
RP Kong, FJ; Qu, S (corresponding author), Tongji Univ, Shanghai Peoples Hosp 10, Sch Med, Dept Endocrinol & Metab, Shanghai, Peoples R China.
EM kongfeijuan@163.com; qushencn@hotmail.com
RI Qu, Shen/B-3405-2014
FU National Natural Science Foundation of China [81401633]
FX This work was supported by National Natural Science Foundation of China
   (No. 81401633).
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NR 61
TC 91
Z9 110
U1 3
U2 32
PU PORTLAND PRESS LTD
PI LONDON
PA 1ST FLR, 10 QUEEN STREET PLACE, LONDON, ENGLAND
SN 0143-5221
EI 1470-8736
J9 CLIN SCI
JI Clin. Sci.
PD JAN 16
PY 2018
VL 132
IS 1
BP 111
EP 125
DI 10.1042/CS20171432
PG 15
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA GA0DK
UT WOS:000427982800010
PM 29212786
DA 2025-06-11
ER

PT J
AU Irazabal, MV
   Chade, AR
   Eirin, A
AF Irazabal, Maria, V
   Chade, Alejandro R.
   Eirin, Alfonso
TI Renal mitochondrial injury in the pathogenesis of CKD: mtDNA and
   mitomiRs
SO CLINICAL SCIENCE
LA English
DT Review
ID GLOMERULAR-FILTRATION-RATE; CHRONIC KIDNEY-DISEASE; DNA COPY NUMBER;
   METABOLIC SYNDROME; OXIDATIVE STRESS; COLLABORATIVE METAANALYSIS;
   INSULIN-RESISTANCE; HIGHER ALBUMINURIA; DYSFUNCTION; IDENTIFICATION
AB Chronic kidney disease (CKD) is a public health concern that affects over 200 million people worldwide and is associated with a tremendous economic burden. Therefore, deciphering the mechanisms underpinning CKD is crucial to decelerate its progression towards end-stage renal disease (ESRD). Renal tubular cells are populated with a high number of mitochondria, which produce cellular energy and modulate several important cellular processes, including generation of reactive oxygen species (ROS), calcium homeostasis, proliferation, and apoptosis. Over the past few years, increasing evidence has implicated renal mitochondrial damage in the pathogenesis of common etiologies of CKD, such as diabetes, hypertension, metabolic syndrome (MetS), chronic renal ischemia, and polycystic kidney disease (PKD). However, most compelling evidence is based on preclinical studies because renal biopsies are not routinely performed in many patients with CKD. Previous studies have shown that urinary mitochondrial DNA (mtDNA) copy numbers may serve as non-invasive biomarkers of renal mitochondrial dysfunction. Emerging data also suggest that CKD is associated with altered expression of mitochondria-related microRNAs (mitomiRs), which localize in mitochondria and regulate the expression of mtDNA and nucleus-encoded mitochondrial genes. This review summarizes relevant evidence regarding the involvement of renal mitochondrial injury and dysfunction in frequent forms of CKD. We further provide an overview of non-invasive biomarkers and potential mechanisms of renal mitochondrial damage, especially focusing on mtDNA and mitomiRs.
C1 [Irazabal, Maria, V; Eirin, Alfonso] Mayo Clin, Div Nephrol & Hypertens, Dept Internal Med, Rochester, MN 55905 USA.
   [Chade, Alejandro R.] Univ Mississippi, Med Ctr, Dept Physiol & Biophys Med & Radiol, Jackson, MS 39216 USA.
C3 Mayo Clinic; University of Mississippi; University of Mississippi
   Medical Center
RP Eirin, A (corresponding author), Mayo Clin, Div Nephrol & Hypertens, Dept Internal Med, Rochester, MN 55905 USA.
EM eirinmassat.alfonso@mayo.edu
RI Eirin, Alfonso/N-9873-2013
OI Eirin, Alfonso/0000-0002-3864-9644
FU NIH [DK129240, DK104273, DK118391, DK128017 GM104357, HL095638]; PKD
   Foundation [PKDF243G20a]; Regenerative Medicine Minnesota [RMM 091620 DS
   004]; National Institute of General Medical Sciences [P20GM104357]
   Funding Source: NIH RePORTER
FX This work was supported by the NIH [grant numbers DK129240, DK104273,
   DK118391, DK128017 GM104357, HL095638]; the PKD Foundation [grant number
   PKDF243G20a]; and the Regenerative Medicine Minnesota [grant number RMM
   091620 DS 004].
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NR 122
TC 11
Z9 12
U1 1
U2 10
PU PORTLAND PRESS LTD
PI LONDON
PA 1ST FLR, 10 QUEEN STREET PLACE, LONDON, ENGLAND
SN 0143-5221
EI 1470-8736
J9 CLIN SCI
JI Clin. Sci.
PD MAR
PY 2022
VL 136
IS 5
BP 345
EP 360
DI 10.1042/CS20210512
PG 16
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 0P0EP
UT WOS:000783895600004
PM 35260892
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Juhasz, I
   Ujfalusi, S
   Seres, I
   Lorincz, H
   Varga, VE
   Paragh, G
   Somodi, S
   Harangi, M
   Paragh, G
AF Juhasz, Imre
   Ujfalusi, Szilvia
   Seres, Ildiko
   Lorincz, Hajnalka
   Varga, Viktoria Evelin
   Paragh, Gyoergy, Jr.
   Somodi, Sandor
   Harangi, Mariann
   Paragh, Gyoergy
TI Afamin Levels and Their Correlation with Oxidative and Lipid Parameters
   in Non-diabetic, Obese Patients
SO BIOMOLECULES
LA English
DT Article
DE obesity; insulin resistance; afamin; HDL subfractions; vitamin E
ID ALPHA-TOCOPHEROL SUPPLEMENTATION; VITAMIN-E; PLASMA; PEROXIDATION;
   ATHEROSCLEROSIS; DYSLIPIDEMIA
AB Background: Afamin is a liver-produced bioactive protein and features alpha- and gamma-tocopherol binding sites. Afamin levels are elevated in metabolic syndrome and obesity and correlate well with components of metabolic syndrome. Afamin concentrations, correlations between afamin and vitamin E, afamin and lipoprotein subfractions in non-diabetic, obese patients have not been fully examined. Methods: Fifty non-diabetic, morbidly obese patients and thirty-two healthy, normal-weight individuals were involved in our study. The afamin concentrations were measured by ELISA. Lipoprotein subfractions were determined with gel electrophoresis. Gas chromatography-mass spectrometry was used to measure alpha- and gamma tocopherol levels. Results: Afamin concentrations were significantly higher in the obese patients compared to the healthy control (70.4 +/- 12.8 vs. 47.6 +/- 8.5 mu g/mL, p < 0.001). Positive correlations were found between afamin and fasting glucose, HbA1c, hsCRP, triglyceride, and oxidized LDL level, as well as the amount and ratio of small HDL subfractions. Negative correlations were observed between afamin and mean LDL size, as well as the amount and ratio of large HDL subfractions. After multiple regression analysis, HbA1c levels and small HDL turned out to be independent predictors of afamin. Conclusions: Afamin may be involved in the development of obesity-related oxidative stress via the development of insulin resistance and not by affecting alpha- and gamma-tocopherol levels.
C1 [Juhasz, Imre; Somodi, Sandor] Univ Debrecen, Dept Emergency Med, Fac Med, H-4032 Debrecen, Hungary.
   [Juhasz, Imre; Ujfalusi, Szilvia] Univ Debrecen, Doctoral Sch Hlth Sci, Fac Publ Hlth, H-4032 Debrecen, Hungary.
   [Ujfalusi, Szilvia; Seres, Ildiko; Lorincz, Hajnalka; Varga, Viktoria Evelin; Harangi, Mariann; Paragh, Gyoergy] Univ Debrecen, Dept Internal Med, Fac Med, H-4032 Debrecen, Hungary.
   [Paragh, Gyoergy, Jr.] Roswell Park Comprehens Canc Ctr, Dept Dermatol, Buffalo, NY 14203 USA.
   [Paragh, Gyoergy, Jr.] Roswell Park Comprehens Canc Ctr, Dept Cell Stress Biol, Buffalo, NY 14203 USA.
C3 University of Debrecen; University of Debrecen; University of Debrecen;
   Roswell Park Comprehensive Cancer Center; Roswell Park Comprehensive
   Cancer Center
RP Paragh, G (corresponding author), Univ Debrecen, Dept Internal Med, Fac Med, H-4032 Debrecen, Hungary.
EM juhaszimre86@gmail.com; ujfalusisz@gmail.com; seres@belklinika.com;
   harangi@belklinika.com; vargavikievelin@gmail.com; gparagh@gmail.com;
   somodi@belklinika.com; harangi@belklinika.com; paragh@belklinika.com
RI Harangi, Mariann/ACY-2278-2022
OI Harangi, Mariann/0000-0001-9761-9595; Somodi,
   Sandor/0000-0002-3615-2300; Lorincz, Hajnalka/0009-0000-5303-3082
FU Bridging Fund-University of Debrecen, Faculty of Medicine; National
   Research, Development and Innovation Office-NKFIH [K115723, PD124126];
   European Union under the European Regional Development Fund; 
   [GINOP-2.3.2-15-2016-00005]
FX The work is supported by the Bridging Fund-University of Debrecen,
   Faculty of Medicine (date obtained: 1 September 2021); by the National
   Research, Development and Innovation Office-NKFIH, grant number: K115723
   (date of obtaining: 1 November 2015), PD124126 (date obtained: 1
   September 2017) and by the GINOP-2.3.2-15-2016-00005 project (date of
   obtaining: 1 September 2016). The GINOP project is co-financed by the
   European Union under the European Regional Development Fund.
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NR 38
TC 11
Z9 12
U1 2
U2 14
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2218-273X
J9 BIOMOLECULES
JI Biomolecules
PD JAN
PY 2022
VL 12
IS 1
AR 116
DI 10.3390/biom12010116
PG 11
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA YO8XY
UT WOS:000748218100001
PM 35053264
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Nakama, RP
   Malvezi, AD
   Lovo-Martins, MI
   dos Santos, LF
   Cardoso, APC
   Scacco, G
   de Freitas, AMD
   Martins-Pinge, MC
   Pinge, P
AF Nakama, Raquel Pires
   Malvezi, Aparecida Donizette
   Lovo-Martins, Maria Isabel
   dos Santos, Lucas Felipe
   Canizares Cardoso, Ana Paula
   Scacco, Gustavo
   Dionisio de Freitas, Andressa Mendes
   Martins-Pinge, Marli Cardoso
   Pinge-Filho, Phileno
TI Metabolic syndrome improves cardiovascular dysfunction and survival
   during cecal ligation and puncture-induced mild sepsis in mice
SO LIFE SCIENCES
LA English
DT Article
DE Obesity; Nitric oxide; Cecal ligation and puncture; Obesity paradox;
   Cardiovascular parameters
ID RENIN-ANGIOTENSIN SYSTEM; NITRIC-OXIDE; ADIPOSE-TISSUE; NEUTROPHIL
   MIGRATION; OXIDATIVE STRESS; OBESITY; INHIBITION; FAILURE; NO;
   MODULATION
AB Aims: Sepsis is a potentially fatal systemic inflammatory response and its underlying pathophysiology is still poorly understood. Studies suggest that obesity, a component of metabolic syndrome (MS), is associated with sepsis survival. Therefore, this study focused on investigating the influence of MS on mortality and cardiovascular dysfunction induced by sublethal cecal ligation and puncture (SL-CLP). Main methods: Newborn Swiss mice received monosodium glutamate (MSG) (4 mg kg-1 day-1, s.c.) during the first 5 d of life for MS induction, while the control pups received equimolar saline solution. On the 75th day, SLCLP was used to induce mild sepsis (M-CLP) in the MS (MS-M-CLP) and control (SAL-M-CLP) mice. The effect of MS on sepsis in mice was assessed by determining the survival rate and quantification of nitric oxide (NO) in the plasma, and associating this data with hematological and cardiovascular parameters. Key findings: MS improved the survival of septic mice, preventing impairment to hematological and cardiovascular parameters. In addition, MS attenuated plasmatic NO increase, which is a typical feature of sepsis. Significance: These findings provide new insights into the relationship between obesity and mild sepsis in mice, thus revealing an approach in favor of the "obesity paradox."
C1 [Nakama, Raquel Pires; Malvezi, Aparecida Donizette; Lovo-Martins, Maria Isabel; Canizares Cardoso, Ana Paula; Pinge-Filho, Phileno] Univ Estadual Londrina, Dept Pathol Sci, Postgrad Program Expt Pathol, Londrina, Parana, Brazil.
   [dos Santos, Lucas Felipe; Pinge-Filho, Phileno] Univ Estadual Londrina, Dept Microbiol, Postgrad Program Microbiol, Londrina, Parana, Brazil.
   [Scacco, Gustavo; Dionisio de Freitas, Andressa Mendes; Martins-Pinge, Marli Cardoso] Univ Estadual Londrina, Dept Physiol Sci, Postgrad Program Physiol Sci, Londrina, Parana, Brazil.
C3 Universidade Estadual de Londrina; Universidade Estadual de Londrina;
   Universidade Estadual de Londrina
RP Pinge, P (corresponding author), Univ Estadual Londrina, Ctr Ciencias Biol, Dept Ciencias Patol, Lab Imunopatol Expt, BR-86051970 Londrina, Parana, Brazil.
EM pingefilho@uel.br
RI Cardoso, Ana/A-9191-2018; Pinge-Filho, Phileno/G-2844-2012; Pinge,
   Marli/C-4417-2014; Freitas, Andressa/B-7264-2012
OI Freitas, Andressa/0000-0001-8453-7742
FU CAPES (Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior);
   CNPq (Conselho Nacional de Desenvolvimento Cientifico e Tecnologico)
   [307894/2019-3, 305597/2018-3]
FX The authors are grateful for support by CAPES (Coordenacao de
   Aperfeicoamento de Pessoal de Nivel Superior) , for the fellowship to
   RPN and LFS, CNPq (Conselho Nacional de Desenvolvimento Cientifico e
   Tecnologico) , Researcher Scholarship to MCMP (307894/2019-3) and PPF
   (305597/2018-3) .
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NR 51
TC 7
Z9 7
U1 1
U2 2
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0024-3205
EI 1879-0631
J9 LIFE SCI
JI Life Sci.
PD DEC 1
PY 2021
VL 286
AR 120033
DI 10.1016/j.lfs.2021.120033
EA OCT 2021
PG 6
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA WK7IW
UT WOS:000709898200006
PM 34627775
DA 2025-06-11
ER

PT J
AU Dongiovanni, P
   Ruscica, M
   Rametta, R
   Recalcati, S
   Steffani, L
   Gatti, S
   Girelli, D
   Cairo, G
   Magni, P
   Fargion, S
   Valenti, L
AF Dongiovanni, Paola
   Ruscica, Massimiliano
   Rametta, Raffaela
   Recalcati, Stefania
   Steffani, Liliana
   Gatti, Stefano
   Girelli, Domenico
   Cairo, Gaetano
   Magni, Paolo
   Fargion, Silvia
   Valenti, Luca
TI Dietary Iron Overload Induces Visceral Adipose Tissue Insulin Resistance
SO AMERICAN JOURNAL OF PATHOLOGY
LA English
DT Article
ID FATTY LIVER; METABOLIC SYNDROME; OXIDATIVE STRESS; MODEL;
   STEATOHEPATITIS; RESTRICTION; FERROPORTIN; EXPRESSION; DEPLETION; CELLS
AB Increased iron stores associated with elevated levels of the iron hormone hepcidin are a frequent feature of the metabolic syndrome. The aim of this study was to assess the effect of dietary iron supplementation on insulin resistance and the role of hepcidin in C57Bl/6 male mice fed a standard or iron-enriched diet for 16 weeks. Iron supplementation increased hepatic iron and serum hepcidin fivefold and led to a 40% increase in fasting glucose due to insulin resistance, as confirmed by the insulin tolerance test, and to threefold higher levels of triglycerides. Iron supplemented mice had Lower visceral adipose tissue mass estimated by epididymal fat pad, associated with iron accumulation in adipocytes. Decreased insulin signaling, evaluated by the phospho-Akt/Akt ratio, was detected in the visceral adipose tissue of iron overloaded mice, and gene expression analysis of visceral adipose tissue showed that an iron-enriched diet up-regulated iron-responsive genes and adipokines, favoring insulin resistance, whereas Lipoprotein Lipase was down-regulated. This resulted in hyperresistinemia and increased visceral adipose tissue expression of suppressor of cytokine signaling-3 (Socs3), a target of resistin and hepcidin implicated in insulin resistance. Acute hepcidin administration down-regulated lipoprotein Lipase and up-regulated Socs3 in visceral adipose tissue. In conclusion, we characterized a model of dysmetabolic iron overload syndrome in which an iron-enriched diet induces insulin resistance and hypertriglyceridemia and affects visceral adipose tissue metabolism by a mechanism involving hepcidin up-regulation.
C1 [Dongiovanni, Paola; Rametta, Raffaela; Fargion, Silvia; Valenti, Luca] Univ Milan, Dept Pathophysiol & Transplantat, Ctr Malattie Metab Fegato, I-20122 Milan, Italy.
   [Dongiovanni, Paola; Rametta, Raffaela; Fargion, Silvia; Valenti, Luca] Fdn IRCCS Ca Granda Osped Maggiore Policlin, Milan, Italy.
   [Ruscica, Massimiliano; Steffani, Liliana; Magni, Paolo] Univ Milan, Dept Pharmacol & Biomelecular Sci, I-20122 Milan, Italy.
   [Recalcati, Stefania; Cairo, Gaetano] Univ Milan, Dept Human Morphol & Biomed Sci Citta Studi, I-20122 Milan, Italy.
   [Gatti, Stefano] Fdn IRCCS Ca Granda Osped Maggiore Policlin, Preclin Surg Res Ctr, Milan, Italy.
   [Girelli, Domenico; Valenti, Luca] Univ Verona, Dept Med, Sect Internal Med, I-37100 Verona, Italy.
C3 University of Milan; IRCCS Ca Granda Ospedale Maggiore Policlinico;
   University of Milan; University of Milan; IRCCS Ca Granda Ospedale
   Maggiore Policlinico; University of Verona
RP Valenti, L (corresponding author), Univ Milan, Dept Pathophysiol & Transplantat, Fdn IRCCS Ca Granda Osped Maggiore Policlin, Via F Sforza 35, I-20122 Milan, Italy.
EM luca.valenti@unimi.it
RI Dongiovanni, Paola/AAC-9965-2019; Girelli, Domenico/B-1183-2008;
   recalcati, stefania/M-5045-2016; Gatti, Stefano/M-1780-2015; Valenti,
   Luca/B-3695-2009; Ruscica, Massimiliano/K-7133-2012; Cairo,
   Gaetano/M-5104-2016
OI Dongiovanni, Paola/0000-0003-4343-7213; recalcati,
   stefania/0000-0002-2115-8283; MAGNI, PAOLO/0000-0002-2254-8881; rametta,
   raffaela/0000-0003-0091-9394; GIRELLI, Domenico/0000-0001-9684-1899;
   Gatti, Stefano/0000-0003-2209-4338; Valenti, Luca/0000-0001-8909-0345;
   Ruscica, Massimiliano/0000-0002-0195-7061; Cairo,
   Gaetano/0000-0002-8147-4720
FU Bando Giovani Ricercatori Ricerca Finalizzata; Ministero della Salute e
   delle Politiche Sociali [GR-2007-683265]; Italian Ministry of University
   and Research [200989KXFN]
FX Supported by grants from Bando Giovani Ricercatori Ricerca Finalizzata
   2007, the Ministero della Salute e delle Politiche Sociali (grant
   GR-2007-683265 to L.V.), and an Italian Ministry of University and
   Research grant (200989KXFN to D.G.).
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NR 37
TC 129
Z9 142
U1 0
U2 30
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0002-9440
EI 1525-2191
J9 AM J PATHOL
JI Am. J. Pathol.
PD JUN
PY 2013
VL 182
IS 6
BP 2254
EP 2263
DI 10.1016/j.ajpath.2013.02.019
PG 10
WC Pathology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pathology
GA 155WT
UT WOS:000319781800029
PM 23578384
OA Bronze
DA 2025-06-11
ER

PT J
AU Catalano, PM
AF Catalano, Patrick M.
TI Obesity, insulin resistance, and pregnancy outcome
SO REPRODUCTION
LA English
DT Review
ID GESTATIONAL DIABETES-MELLITUS; BODY-MASS INDEX; NORMAL
   GLUCOSE-TOLERANCE; FETAL-GROWTH; LONGITUDINAL CHANGES; MATERNAL OBESITY;
   UNITED-STATES; WOMEN; PREECLAMPSIA; SENSITIVITY
AB There has been a significant increase over the past few decades in the number of reproductive age women who are either overweight or obese. Overweight and obese women are at increased risk for having decreased insulin sensitivity as compared with lean or average weight women. The combination of obesity and decreased insulin sensitivity increases the long-term risk of these individuals developing the metabolic syndrome and associated problems of diabetes, hypertension, hyperlipidemia, and cardiovascular disorders. Because of the metabolic alterations during normal pregnancy, particularly the 60% decrease in insulin sensitivity, overweight and obese women are at increased risk of metabolic dysregulation in pregnancy, i.e. gestational diabetes, preeclampsia, and fetal overgrowth. Hence, pregnancy can be considered as a metabolic stress test for the future risk of the metabolic syndrome. In this review, we will review the underlying pathophysiology related to these disorders. Most importantly, an understanding of these risks provides an opportunity for prevention. For example, a planned pregnancy offers an opportunity to address weight control prior to conception. At the very least, by avoiding excessive weight gain during pregnancy, this may prevent excessive weight retention post partum. Finally, based on the concept of in utero programming, these lifestyle measures may not only have short- and long-term benefits for the woman but also for her offspring as well. Reproduction (2010) 140 365-371
C1 Case Western Reserve Univ, Dept Reprod Biol, Metrohlth Med Ctr, Cleveland, OH 44109 USA.
C3 University System of Ohio; Case Western Reserve University; MetroHealth
   System
RP Catalano, PM (corresponding author), Case Western Reserve Univ, Dept Reprod Biol, Metrohlth Med Ctr, Cleveland, OH 44109 USA.
EM pcatalano@metrohealth.org
RI Catalano, Patrick/GVR-9069-2022
FU NIH [HD 22965]
FX The study was supported by NIH HD 22965.
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NR 47
TC 301
Z9 345
U1 1
U2 32
PU BIOSCIENTIFICA LTD
PI BRISTOL
PA EURO HOUSE, 22 APEX COURT WOODLANDS, BRADLEY STOKE, BRISTOL BS32 4JT,
   ENGLAND
SN 1470-1626
J9 REPRODUCTION
JI Reproduction
PD SEP
PY 2010
VL 140
IS 3
BP 365
EP 371
DI 10.1530/REP-10-0088
PG 7
WC Developmental Biology; Reproductive Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Developmental Biology; Reproductive Biology
GA 644KK
UT WOS:000281375200003
PM 20457594
OA Bronze, Green Accepted
DA 2025-06-11
ER

PT J
AU Yang, WQ
   Chen, X
   Chen, M
   Li, YP
   Li, Q
   Jiang, XW
   Yang, Y
   Ling, WH
AF Yang, Wenqi
   Chen, Xu
   Chen, Ming
   Li, Yanping
   Li, Qing
   Jiang, Xinwei
   Yang, Yan
   Ling, Wenhua
TI Fish oil supplementation inhibits endoplasmic reticulum stress and
   improves insulin resistance: involvement of AMP-activated protein kinase
SO FOOD & FUNCTION
LA English
DT Article
ID WHITE ADIPOSE-TISSUE; HEPATIC ER STRESS; FATTY-ACIDS; METABOLIC
   SYNDROME; GLUCOSE-TOLERANCE; LINKS OBESITY; IN-VIVO; INFLAMMATION; MICE;
   SENSITIVITY
AB The beneficial effects of fish oil consumption on glucose metabolism have been generally reported. However, the mechanism underlying the fish oil-induced protective effects against insulin resistance remains unclear. Endoplasmic reticulum (ER) stress is recognized as an important contributor to insulin resistance. The aim of this study is to evaluate whether fish oil supplementation reduces ER stress and ameliorates insulin resistance in diet-induced obese mice, and to investigate the molecular mechanism of fish oil-induced benefits on ER stress. C57BL/6J mice were fed one of the following diets for 12 weeks: the low-fat diet (LFD), the high-fat diet (HFD) or the fish oil-supplemented high-fat diet (FOD). Fish oil supplementation led to lower blood glucose, better glucose tolerance and improved insulin sensitivity in high-fat diet-induced obese mice. Importantly, fish oil administration inhibited high-fat feeding-induced ER stress and reduced adipose tissue dysfunction. The fish oil-induced improvements were accompanied by the elevation of phosphorylated AMP-activated protein kinase (AMPK) expression in white adipose tissue. Correspondingly, the results of in vitro experiments showed that docosahexaenoic acid (DHA), the main n-3 polyunsaturated fatty acid (PUFA) in the fish oil used in the study, led to a dose-dependent increase in AMPK phosphorylation and suppressed palmitic acid (PA)-triggered ER stress in differentiated 3T3-L1 adipocytes. Furthermore, AMPK inhibitor (compound C) treatment largely blocked the effects of DHA to inhibit PA-induced ER stress. Our data indicate that n-3 PUFAs suppress ER stress in adipocytes through AMPK activation, and may thereby exert protective effects against high-fat feeding-induced adipose tissue dysfunction and insulin resistance.
C1 [Yang, Wenqi; Chen, Xu; Chen, Ming; Li, Yanping; Li, Qing; Jiang, Xinwei; Yang, Yan; Ling, Wenhua] Sun Yat Sen Univ, Sch Publ Hlth, Dept Nutr, Guangzhou, Guangdong, Peoples R China.
   [Yang, Yan; Ling, Wenhua] Guangdong Prov Key Lab Food Nutr & Hlth, Guangzhou, Guangdong, Peoples R China.
C3 Sun Yat Sen University
RP Yang, Y; Ling, WH (corresponding author), Sun Yat Sen Univ, Sch Publ Hlth, Dept Nutr, Guangzhou, Guangdong, Peoples R China.; Yang, Y; Ling, WH (corresponding author), Guangdong Prov Key Lab Food Nutr & Hlth, Guangzhou, Guangdong, Peoples R China.
EM yangyan3@mail.sysu.edu.cn; lingwh@mail.sysu.edu.cn
RI Li, Qing/MGU-6637-2025; Chen, Xu/KMX-8502-2024
OI Yang, Yan/0000-0002-5662-4600; Chen, Xu/0000-0002-0545-3936
FU Major Projects of Guangzhou Health Collaborative Innovation [20,
   5100042050027]; National Natural Science foundation of China [81370528,
   81573142]
FX This work was supported by grants from the Major Projects of Guangzhou
   Health Collaborative Innovation (no. 20, Topic 4, Phase III,
   5100042050027), the National Natural Science foundation of China
   (81370528) and the National Natural Science foundation of China
   (81573142).
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NR 53
TC 38
Z9 40
U1 2
U2 39
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PD APR 1
PY 2017
VL 8
IS 4
BP 1481
EP 1493
DI 10.1039/c6fo01841f
PG 13
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA ES8JY
UT WOS:000399804500010
PM 28327709
DA 2025-06-11
ER

PT J
AU Stolt, LROG
   Kolish, DV
   Cardoso, MRA
   Tanaka, C
   Vasconcelos, EFS
   Pereira, EC
   Dellú, MC
   Pereira, WMP
   Aldrighi, JM
   Schmitt, ACB
AF Gomes Stolt, Ligia Raquel Ortiz
   Kolish, Daniel Vieira
   Alves Cardoso, Maria Regina
   Tanaka, Clarice
   Silva Vasconcelos, Erika Flauzino
   Pereira, Elaine Cristina
   Dellu, Mayra Cecilia
   Paixao Pereira, Wendry Maria
   Aldrighi, Jose Mendes
   Basso Schmitt, Ana Carolina
TI Accidental falls in middle-aged women
SO REVISTA DE SAUDE PUBLICA
LA English
DT Article
DE Women; Fall Accidents; External Causes; Epidemiology; Prevalence
ID METABOLIC SYNDROME; OLDER-ADULTS; RISK-FACTORS; PREVENTION; VALIDATION;
   VERSION; GAIT
AB OBJECTIVE: To estimate the prevalence of accidental falls in women and to identify possible associations of sociodemographic, clinical and lifestyle variables with falls, in 2007 and 2014.
   METHODS: Two cross-sectional studies were performed, in 2007 and 2014, within the Projeto de Saude de Pindamonhangaba (PROSAPIN - Pindamonhangaba Health Project), with women aged between 35 to 75 years. Probabilistic samples were selected among women living in the municipality and participating in the Health Family Strategy. Data collection included: face-to-face interview, anthropometric examination and blood test. The outcome variable "have you fallen in the last six months?" was raised during the interview. The prevalence of falls in 2007 and 2014 were estimated by score with a 95% confidence interval (95%CI). Multiple logistic regression models were constructed to identify the association of independent variables with the occurrence of falls for each year based on the odds ratio (OR). We used the Stata 14.0 software for statistical analysis.
   RESULTS: The prevalence of accidental falls were: 17.6% ( 95%CI 14.9-20.5) in 2007 and 17.2% (95%CI 14.8-19.8) in 2014. In 2007, factors associated with falls were: aged 50-64 years (OR = 1.81; 95%CI 1.17-2.80), high school (OR = 1.76; 95%CI 1.06-2.93), hyperuricemia (OR = 3.74; 95%CI 2.17-6.44), depression (OR = 2.07; 95%CI 1.31-3.27), poor sleep (OR = 1.78; 95%CI 1.12-2.82) and daytime sleepiness (OR = 1.86; 95%CI 1.16-2.99). In 2014, they were: aged 50-64 years (OR = 1.64; 95% CI 1.04-2.58), hyperuricemia (OR = 1.91; 95%CI 1.07-3.43) and depression (OR = 1.56; 95%CI 1.02-2.38), plus metabolic syndrome (OR = 1.60; 95%CI 1.03-2.47) and musculoskeletal pain (OR = 1.81; 95%CI 1.03-3.18).
   CONCLUSIONS: Falls occur significantly in women aged 50 years or over, indicating that they are not restricted to older adults and that there is a need to initiate preventive measures earlier. Both studies showed similar magnitudes of occurrence of accidental falls and reinforced their multifactorial nature. In addition, hyperuricemia may be a potential new factor associated with falls.
C1 [Gomes Stolt, Ligia Raquel Ortiz] Univ Fed Paraiba, Dept Fisioterapia, Cidade Univ S-N, BR-58059900 Joao Pessoa, Paraiba, Brazil.
   [Gomes Stolt, Ligia Raquel Ortiz; Tanaka, Clarice; Basso Schmitt, Ana Carolina] Univ Sao Paulo, Fac Med, Programa Posgrad Ciencias Reabilitacao, Sao Paulo, SP, Brazil.
   [Kolish, Daniel Vieira] Articulab Ortopedia Moderna Especializada, Reabilitacao Ortoped & Facilitador Proc Trabalho, Sao Paulo, SP, Brazil.
   [Alves Cardoso, Maria Regina] Univ Sao Paulo, Fac Saude Publ, Dept Epidemiol, Sao Paulo, SP, Brazil.
   [Tanaka, Clarice; Basso Schmitt, Ana Carolina] Univ Sao Paulo, Fac Med, Dept Fisioterapia Fonoaudiol Terapia Ocupac, Sao Paulo, SP, Brazil.
   [Silva Vasconcelos, Erika Flauzino; Pereira, Elaine Cristina; Paixao Pereira, Wendry Maria] Ctr Univ FUNVIC, Curso Fisioterapia, Pindamonhangaba, SP, Brazil.
   [Dellu, Mayra Cecilia] Univ Taubate, Dept Fisioterapia, Taubate, SP, Brazil.
   [Aldrighi, Jose Mendes] Univ Sao Paulo, Fac Saude Publ, Dept Saude Materno Infantil, Sao Paulo, SP, Brazil.
   [Tanaka, Clarice] Univ Sao Paulo, Fac Med, Hosp Clin, Lab Invest Fisioterapia, Sao Paulo, SP, Brazil.
C3 Universidade Federal da Paraiba; Universidade de Sao Paulo; Universidade
   de Sao Paulo; Universidade de Sao Paulo; Universidade de Taubate;
   Universidade de Sao Paulo; Universidade de Sao Paulo
RP Stolt, LROG (corresponding author), Univ Fed Paraiba, Dept Fisioterapia, Cidade Univ S-N, BR-58059900 Joao Pessoa, Paraiba, Brazil.
EM ligiaoruz@outlook.com
RI Pereira, Elaine/ABA-3442-2020; Schmitt, Ana/E-2311-2012; Tanaka,
   Clarice/J-5075-2016
OI Tanaka, Clarice/0000-0003-3900-5944; STOLT, LIGIA/0000-0001-6567-8814
FU Coordenacao de Aperfeicoamento Pessoal de Nivel Superior (Capes)
   [023/2014]; Fundacao de Amparo a Pesquisa do Estado de Sao Paulo
   [303049/2007-3, 06/57016-2]
FX Coordenacao de Aperfeicoamento Pessoal de Nivel Superior (Capes). DINTER
   Notice 023/2014. Fundacao de Amparo a Pesquisa do Estado de Sao Paulo.
   Academic scholarship 303049/2007-3. Funding 06/57016-2.
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NR 32
TC 5
Z9 5
U1 1
U2 4
PU REVISTA DE SAUDE PUBLICA
PI SAO PAULO
PA FACULDADE SAUDE PUBL DA USP, AV DR ARNALDO 715, 01246-904SP SAO PAULO,
   BRAZIL
SN 0034-8910
EI 1518-8787
J9 REV SAUDE PUBL
JI Rev. Saude Publica
PY 2020
VL 54
AR 141
DI 10.11606/s1518-8787.2020054002579
PG 11
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA PH4EE
UT WOS:000600367300012
PM 33331487
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Grattagliano, I
   de Bari, O
   Bernardo, TC
   Oliveira, PJ
   Wang, DQH
   Portincasa, P
AF Grattagliano, Ignazio
   de Bari, Ornella
   Bernardo, Telma C.
   Oliveira, Paulo J.
   Wang, David Q. -H.
   Portincasa, Piero
TI Role of mitochondria in nonalcoholic fatty liver disease-from origin to
   propagation
SO CLINICAL BIOCHEMISTRY
LA English
DT Review
DE Breath tests; Nonalcoholic fatty liver disease; Mitochondria; Oxidative
   stress; Fatty acid beta-oxidation
ID PERMEABILITY TRANSITION; HEPATIC STEATOSIS; OXIDATIVE STRESS; ACID
   OXIDATION; MACROVESICULAR STEATOSIS; METABOLIC SYNDROME; BETA-OXIDATION;
   COMPLEX-I; RAT; DYSFUNCTION
AB Objectives: Mitochondria play a major role in cell energy-generating processes and integrate several signalling pathways to control cellular life and death.
   Design and methods: Several liver diseases are characterized by mitochondrial alterations which are directly or indirectly dependent on the activation of intracellular stress cascades or receptor-mediated pathways. This article examines the role of mitochondrial dysfunction in critical initiating or propagating events in fatty liver infiltration and nonalcoholic fatty liver disease (NAFLD). Genetic variants and the role of drug-induced toxicity have been considered.
   Results: Key alterations of mitochondrial physiology associated with hepatocyte fatty changes are described. The value of novel non-invasive diagnostic methods to detect mitochondria( metabolic alterations is also discussed.
   Conclusions: Mitochondrial metabolic remodeling is a predominant factor in the appearance and perpetuation of hepatocyte fat accumulation. Non-invasive techniques to identify mitochondrial dysfunction and proper mitochondria protection are two necessary clinical steps for an efficient management of NAFLD. (C) 2012 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
C1 [Grattagliano, Ignazio; de Bari, Ornella; Portincasa, Piero] Univ Bari, Dept Interdisciplinary Med, Clin Med A Murri, Sch Med, Bari, Italy.
   [de Bari, Ornella; Wang, David Q. -H.] St Louis Univ, Sch Med, Dept Internal Med, Div Gastroenterol & Hepatol, St Louis, MO USA.
   [Bernardo, Telma C.; Oliveira, Paulo J.] Univ Coimbra, CNC Ctr Neurosci & Cell Biol, P-3000 Coimbra, Portugal.
C3 Universita degli Studi di Bari Aldo Moro; Saint Louis University;
   Universidade de Coimbra
RP Grattagliano, I (corresponding author), Univ Bari, Dept Interdisciplinary Med, Clin Med A Murri, Sch Med, Bari, Italy.
EM i.grattagliano@semeiotica.uniba.it
RI portincasa, piero/J-7245-2018; Oliveira, Paulo/AAQ-8943-2020; wang,
   David/KFR-2555-2024; Bernardo, Telma/A-2933-2012; Oliveira,
   Paulo/H-1980-2011
OI portincasa, piero/0000-0001-5359-1471; Oliveira,
   Paulo/0000-0002-5201-9948
FU National Institutes of Health (US Public Health Service) [DK54012,
   DK73917]; FIRB from Italian Ministry of University and Research [2003
   RBAU01RANB002]; Italian National Research Council (CNR); Portuguese
   Foundation for Science and Technology [PTDC/SAU-TOX/110952/2009];
   Fundação para a Ciência e a Tecnologia [PTDC/SAU-TOX/110952/2009]
   Funding Source: FCT
FX This work was supported in part by research grants DK54012 and DK73917
   (D.Q.-H.W.) from the National Institutes of Health (US Public Health
   Service), and FIRB 2003 RBAU01RANB002 (P.P.) from the Italian Ministry
   of University and Research. P.P. was a recipient of the short-term
   mobility grant 2005 from the Italian National Research Council (CNR).
   P.J.O. is funded by the Portuguese Foundation for Science and Technology
   (research grant PTDC/SAU-TOX/110952/2009).
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NR 104
TC 109
Z9 118
U1 1
U2 32
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0009-9120
EI 1873-2933
J9 CLIN BIOCHEM
JI Clin. Biochem.
PD JUN
PY 2012
VL 45
IS 9
BP 610
EP 618
DI 10.1016/j.clinbiochem.2012.03.024
PG 9
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA 957NG
UT WOS:000305169100003
PM 22484459
DA 2025-06-11
ER

PT J
AU Okuyama, H
   Son, A
   Ahsan, MK
   Masutani, H
   Nakamura, H
   Yodoi, J
AF Okuyama, Hiroaki
   Son, Aoi
   Ahsan, Md. Kaimul
   Masutani, Hiroshi
   Nakamura, Hajime
   Yodoi, Junji
TI Thioredoxin and thioredoxin binding protein 2 in the liver
SO IUBMB LIFE
LA English
DT Review
DE antioxidants; cellular glucose metabolism; fatty acids; metabolic
   syndrome; oxidative stress; redox; ROS
ID LEUKEMIA-DERIVED FACTOR; UP-REGULATED PROTEIN-1; REDOX REGULATION;
   TRANSGENIC MICE; POSSIBLE INVOLVEMENT; OXIDATIVE STRESS; T-CELLS;
   HTLV-I; EXPRESSION; OVEREXPRESSION
AB Thioredoxin (TRX) is a 12-kDa protein with redox-active dithiol in the active site -Cys-GlY-Pro-CYs- and constitutes a major thiol reducing sytem. TRX protects cells front stress-induced damage throng It antioxidative, antiapoptotic, and anti-inflammatory effect. In animal models, thioacetamide (TAA)induced acute hepatitis and TAA-induced liver fibrosis was attenuated in TRX transgenic (TRXTG) mice. Plasma level of TRX is a good marker for hepatitis and nonalcoholic steatohepatitis (NASH) in human patients. Recently, we identified TRX binding protein 2 (TBP2) in it yeast two-hybrid screening. TBP2 regulates both the expression and reducing activity of TRX its well its cell growth. TBP2 knockout (TBP2KO) mice showed disorder in lipid metabolism. TBP2 plays it multiple role on cell growth and lipid and glucose metabolism. Thus, TRX and TBP2 play important roles in the pathophysiology of liver diseases, including NASH, indicating that ratio of TRX and TBP2 expression could be a novel marker of liver diseases like NASH. (C) 2008 IUBMB.
C1 [Yodoi, Junji] Kyoto Univ, Dept Biol Responses, Inst Virus Res, Sakyo Ku, Kyoto 6068507, Japan.
   [Okuyama, Hiroaki; Ahsan, Md. Kaimul; Nakamura, Hajime] Kyoto Univ Hosp, Translat Res Ctr, Thioredoxin Project, Dept Expt Therapeut, Kyoto 606, Japan.
C3 Kyoto University; Kyoto University
RP Yodoi, J (corresponding author), Kyoto Univ, Dept Biol Responses, Inst Virus Res, Sakyo Ku, 53 Shogoin, Kyoto 6068507, Japan.
EM yodoi@virus.kyoto-u.ac.jp
RI Masutani, Hiroshi/B-5114-2014; Yodoi, Junji/F-6189-2011
OI Masutani, Hiroshi/0000-0001-7633-2827
FU Grant-in-Aid for the Creation of Innovations through
   Business-Academic-Public Sector Cooperation; Ministry of Education,
   Culture, Sports, Science and Technology of Japan
FX This work was supported by a Grant-in-Aid for the Creation of
   Innovations through Business-Academic-Public Sector Cooperation and Open
   Competition for the Development of Innovative Technology, from the
   Ministry of Education, Culture, Sports, Science and Technology of Japan.
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NR 31
TC 21
Z9 22
U1 0
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1521-6543
EI 1521-6551
J9 IUBMB LIFE
JI IUBMB Life
PD OCT
PY 2008
VL 60
IS 10
BP 656
EP 660
DI 10.1002/iub.102
PG 5
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA 355LE
UT WOS:000259709600003
PM 18636507
OA Bronze
DA 2025-06-11
ER

PT J
AU Chakrala, T
   Prakash, R
   Valdes, C
   Pepine, CJ
   Keeley, EC
AF Chakrala, Teja
   Prakash, Roshni
   Valdes, Carlos
   Pepine, Carl J. J.
   Keeley, Ellen C. C.
TI Circulating Biomarkers in Coronary Microvascular Dysfunction
SO JOURNAL OF THE AMERICAN HEART ASSOCIATION
LA English
DT Review
DE biomarker; circulating molecules; coronary microvascular dysfunction
ID C-REACTIVE PROTEIN; SOLUBLE ADHESION MOLECULES; CARDIAC SYNDROME-X;
   PLASMA ASYMMETRIC DIMETHYLARGININE; IMPROVES ENDOTHELIAL FUNCTION; HDL
   CHOLESTEROL RATIO; RHO-KINASE ACTIVITY; ANGINA-PECTORIS; CHEST-PAIN;
   SYSTEMIC INFLAMMATION
AB Coronary microvascular dysfunction is an underdiagnosed pathologic process that is associated with adverse clinical outcomes. Biomarkers, molecules measurable in the blood, could inform the clinician by aiding in the diagnosis and management of coronary microvascular dysfunction. We present an updated review of circulating biomarkers in coronary microvascular dysfunction representing key pathologic processes, including inflammation, endothelial dysfunction, oxidative stress, coagulation, and other mechanisms.
C1 [Chakrala, Teja; Prakash, Roshni; Valdes, Carlos; Pepine, Carl J. J.; Keeley, Ellen C. C.] Univ Florida, Dept Med, Gainesville, FL USA.
   [Pepine, Carl J. J.; Keeley, Ellen C. C.] Univ Florida, Div Cardiovasc Med, 1329 SW 16th St,POB 100288, Gainesville, FL 32608 USA.
C3 State University System of Florida; University of Florida; State
   University System of Florida; University of Florida
RP Keeley, EC (corresponding author), Univ Florida, Div Cardiovasc Med, 1329 SW 16th St,POB 100288, Gainesville, FL 32608 USA.
EM ellen.keeley@medicine.ufl.edu
OI Pepine, Carl/0000-0002-6011-681X; Keeley, Ellen/0000-0003-2915-4751;
   Chakrala, Teja/0000-0001-5351-1566; Valdes, Carlos/0000-0002-6156-1165
FU Department of Defense [W81XWH-17-2-0030]
FX <STRONG>& nbsp;</STRONG>This work was funded by the Department of
   Defense W81XWH-17-2-0030 (Dr Pepine).
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NR 99
TC 8
Z9 8
U1 6
U2 56
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
EI 2047-9980
J9 J AM HEART ASSOC
JI J. Am. Heart Assoc.
PD JUN 20
PY 2023
VL 12
IS 12
DI 10.1161/JAHA.122.029341
PG 16
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA K3BW0
UT WOS:001015234300026
PM 37301749
OA gold
DA 2025-06-11
ER

PT J
AU Quagliariello, V
   Berretta, M
   Bisceglia, I
   Giacobbe, I
   Iovine, M
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   Oliva, S
   Dessalvi, CC
   Mauriello, A
   Fonderico, C
   Maratea, AC
   Gabrielli, D
   Maurea, N
AF Quagliariello, Vincenzo
   Berretta, Massimiliano
   Bisceglia, Irma
   Giacobbe, Ilaria
   Iovine, Martina
   Barbato, Matteo
   Maurea, Carlo
   Canale, Maria Laura
   Paccone, Andrea
   Inno, Alessandro
   Scherillo, Marino
   Oliva, Stefano
   Dessalvi, Christian Cadeddu
   Mauriello, Alfredo
   Fonderico, Celeste
   Maratea, Anna Chiara
   Gabrielli, Domenico
   Maurea, Nicola
TI In the Era of Cardiovascular-Kidney-Metabolic Syndrome in
   Cardio-Oncology: From Pathogenesis to Prevention and Therapy
SO CANCERS
LA English
DT Review
DE metabolic syndrome; kidney diseases; cancer; cardio-oncology;
   cardiotoxicity; metabolism; PCSK9; obesity
ID SOLUBLE GUANYLATE-CYCLASE; LOW-GLYCEMIC INDEX; ANGIOTENSIN-ALDOSTERONE
   SYSTEM; FATTY LIVER-DISEASE; MEDITERRANEAN DIET; INSULIN-RESISTANCE;
   RECEPTOR AGONISTS; OXIDATIVE STRESS; RISK; HYPERTENSION
AB Cardiovascular-kidney-metabolic (CKM) syndrome represents a complex interplay between cardiovascular disease (CVD), chronic kidney disease (CKD), and metabolic disorders, significantly impacting cancer patients. The presence of CKM syndrome in cancer patients not only worsens their prognosis but also increases the risk of major adverse cardiovascular events (MACE), reduces quality of life (QoL), and affects overall survival (OS). Furthermore, several anticancer therapies, including anthracyclines, tyrosine kinase inhibitors, immune checkpoint inhibitors, and hormonal treatments, can exacerbate CKM syndrome by inducing cardiotoxicity, nephrotoxicity, and metabolic dysregulation. This review explores the pathophysiology of CKM syndrome in cancer patients and highlights emerging therapeutic strategies to mitigate its impact. We discuss the role of novel pharmacological interventions, including sodium-glucose cotransporter-2 inhibitors (SGLT2i), proprotein convertase subtilisin/kexin type 9 inhibitors (PCSK9i), and soluble guanylate cyclase (sGC) activators, as well as dietary and lifestyle interventions. Optimizing the management of CKM syndrome in cancer patients is crucial to improving OS, enhancing QoL, and reducing MACE. By integrating cardiometabolic therapies into oncologic care, we can create a more comprehensive treatment approach that reduces the burden of cardiovascular and renal complications in this vulnerable population. Further research is needed to establish personalized strategies for CKM syndrome prevention and treatment in cancer patients.
C1 [Quagliariello, Vincenzo; Giacobbe, Ilaria; Iovine, Martina; Barbato, Matteo; Paccone, Andrea; Mauriello, Alfredo; Fonderico, Celeste; Maratea, Anna Chiara; Maurea, Nicola] IRCCS Fdn G Pascale, Ist Nazl Tumori, Div Cardiol, I-80131 Naples, Italy.
   [Berretta, Massimiliano] Univ Messina, Dept Clin & Expt Med, I-98125 Messina, Italy.
   [Bisceglia, Irma] Azienda Osped San Camillo Forlanini, Dipartimento Cardiotoracovasc, Servizi Cardiol Integrati, I-00148 Rome, Italy.
   [Maurea, Carlo] Osped Mare, UOC Neurol & Stroke Unit, ASL NA1, I-23807 Naples, Italy.
   [Canale, Maria Laura] Osped Versilia, UOC Cardiol, I-55041 Lido Di Camaiore, Italy.
   [Inno, Alessandro] IRCCS Osped Sacro Cuore Don Calabria, Med Oncol, I-37024 Negrar Di Valpolicella, Italy.
   [Scherillo, Marino] AO San Pio, Cardiol Interventist & UTIC, Presidio Osped Gaetano Rummo, I-82100 Benevento, Italy.
   [Oliva, Stefano] IRCCS Ist Tumori Giovanni Paolo II, Cardiooncol Unit, I-70124 Bari, Italy.
   [Dessalvi, Christian Cadeddu] Univ Cagliari, Dept Med Sci & Publ Hlth, I-09123 Cagliari, Italy.
   [Gabrielli, Domenico] Azienda Osped San Camillo Forlanini, Dipartimento Cardiotoracovasc, UOC Cardiol, I-00152 Rome, Italy.
C3 IRCCS Fondazione Pascale; Fondazione IRCCS Istituto Nazionale Tumori
   Milan; University of Messina; Azienda Ospedaliera San Camillo-Forlanini;
   Ospedale Versilia; IRCCS Istituto Tumori Bari Giovanni Paolo II;
   University of Cagliari; Azienda Ospedaliera San Camillo-Forlanini
RP Quagliariello, V (corresponding author), IRCCS Fdn G Pascale, Ist Nazl Tumori, Div Cardiol, I-80131 Naples, Italy.
EM quagliariello.enzo@gmail.com
RI Gabrielli, Domenico/AAC-1130-2022; Caturano, Alfredo/AAA-4014-2022;
   Maurea, Nicola/AAC-2341-2022; Iovine, Martina/ABD-8951-2020; Inno,
   Alessandro/AAA-8268-2022; Quagliariello, Vincenzo/GLT-0763-2022;
   Berretta, Massimiliano/S-5853-2019; Quagliariello, Vincenzo/A-8537-2019
OI Berretta, Massimiliano/0000-0002-9837-9148; Quagliariello,
   Vincenzo/0000-0002-4557-5401; , Alfredo/0000-0001-7060-6938
FU The 5 x 1000 Project (5XMILLE_2022_17) titled "Inibitori selettivi di
   PCSK9 e NLRP3 come strategie preventive della cardiotossicita e
   aterosclerosi indotta da farmaci antitumorali: impatto del targeting
   lipidico ed infiammatorio in Cardio-Oncologia" - Mini
FX This research was funded by the 5 x 1000 Project (5XMILLE_2022_17)
   titled "Inibitori selettivi di PCSK9 e NLRP3 come strategie preventive
   della cardiotossicita e aterosclerosi indotta da farmaci antitumorali:
   impatto del targeting lipidico ed infiammatorio in Cardio-Oncologia",
   funded by Ministro della Salute.
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NR 215
TC 0
Z9 0
U1 1
U2 1
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2072-6694
J9 CANCERS
JI Cancers
PD MAR 30
PY 2025
VL 17
IS 7
AR 1169
DI 10.3390/cancers17071169
PG 41
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA 1FF7V
UT WOS:001463615100001
PM 40227756
OA gold
DA 2025-06-11
ER

PT J
AU Xu, CM
   Karbasiafshar, C
   Brinck-Teixeira, R
   Broadwin, M
   Sellke, FW
   Abid, MR
AF Xu, Cynthia M.
   Karbasiafshar, Catherine
   Brinck-Teixeira, Rayane
   Broadwin, Mark
   Sellke, Frank W.
   Abid, M. Ruhul
TI Diabetic state of human coronary artery endothelial cells results in
   altered effects of bone mesenchymal stem cell-derived extracellular
   vesicles
SO PHYSIOLOGICAL REPORTS
LA English
DT Article
DE diabetes; human bone mesenchymal stem cell-derived extracellular
   vesicles; human coronary artery endothelial cells; metabolic syndrome
ID INSULIN-RESISTANCE; ANTIOXIDANT STATUS; NITRIC-OXIDE; ANGIOGENESIS;
   EXOSOMES; DYSFUNCTION; MECHANISMS; MELLITUS; TARGET; AMPK
AB Human bone mesenchymal stem cell-derived extracellular vesicles (HBMSC-EV) have been used successfully in animal models of myocardial ischemia, yet have dampened effects in metabolic syndrome through unknown mechanisms. This study demonstrates the basal differences between non-diabetic human coronary artery endothelial cells (HCAEC) and diabetic HCAEC (DM-HCAEC), and how these cells respond to the treatment of HBMSC-EV. HCAEC and DM-HCAEC were treated with HBMSC-EV for 6 h. Proteomics, western blot analysis, and tube formation assays were performed. Key metabolic, growth, and stress/starvation cellular responses were significantly altered in DM-HCAEC in comparison to that of HCAEC at baseline. Proteomics demonstrated increased phosphorus metabolic process and immune pathways and decreased RNA processing and biosynthetic pathways in DM-HCAEC. Similar to previous in vivo findings, HCAEC responded to the HBMSC-EV with regenerative and anti-inflammatory effects through the upregulation of multiple RNA pathways and downregulation of immune cell activation pathways. In contrast, DM-HCAEC had a significantly diminished response to HBMSC-EV, likely due to the baseline abnormalities in DM-HCAEC. To achieve the full benefits of HBMSC-EV and for a successful transition of this potential therapeutic agent to clinical studies, the abnormalities found in DM-HCAEC will need to be further studied.
C1 [Xu, Cynthia M.; Karbasiafshar, Catherine; Brinck-Teixeira, Rayane; Broadwin, Mark; Sellke, Frank W.; Abid, M. Ruhul] Rhode Isl Hosp, Cardiovasc Res Ctr, Coro West 5-231,1 Hoppin St, Providence, RI 02903 USA.
   [Xu, Cynthia M.; Brinck-Teixeira, Rayane; Broadwin, Mark; Sellke, Frank W.; Abid, M. Ruhul] Brown Univ, Alpert Med Sch, Div Cardiothorac Surg, Providence, RI USA.
   [Xu, Cynthia M.; Brinck-Teixeira, Rayane; Broadwin, Mark; Sellke, Frank W.; Abid, M. Ruhul] Rhode Isl Hosp, Providence, RI USA.
C3 Lifespan Health Rhode Island; Rhode Island Hospital; Brown University;
   Lifespan Health Rhode Island; Rhode Island Hospital
RP Abid, MR (corresponding author), Rhode Isl Hosp, Cardiovasc Res Ctr, Coro West 5-231,1 Hoppin St, Providence, RI 02903 USA.
EM ruhul_abid@brown.edu
RI ; Brinck Teixeira, Rayane/U-8670-2017
OI sellke, frank/0000-0002-8886-801X; Xu, Cynthia/0000-0002-2191-3066;
   Brinck Teixeira, Rayane/0000-0001-9749-6580; Abid,
   Ruhul/0000-0003-2981-2638
FU Rhode Island Foundation
FX No Statement Availabler No Statement Availabler No Statement Availabler
   No Statement Available
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NR 46
TC 0
Z9 0
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2051-817X
J9 PHYSIOL REP
JI PHYSIOL. REP.
PD DEC
PY 2023
VL 11
IS 24
AR e15866
DI 10.14814/phy2.15866
PG 11
WC Physiology
WE Emerging Sources Citation Index (ESCI)
SC Physiology
GA DK0D8
UT WOS:001131804300003
PM 38114067
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Yamamoto, H
   Yoshida, N
   Kihara, S
AF Yamamoto, Hiroyasu
   Yoshida, Nao
   Kihara, Shinji
TI Esaxerenone Blocks Vascular Endothelial Inflammation Through SGK1
SO JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
LA English
DT Article
DE esaxerenone; mineralocorticoid receptor; SGK1; spironolactone; TNF-alpha
ID INDUCIBLE KINASE 1; ANGIOTENSIN-CONVERTING ENZYME; SELECTIVE ALDOSTERONE
   BLOCKER; LEFT-VENTRICULAR DYSFUNCTION; NECROSIS-FACTOR-ALPHA; OXIDATIVE
   STRESS; MINERALOCORTICOID RECEPTORS; METABOLIC SYNDROME; VASOMOTOR
   DYSFUNCTION; ORAI1 EXPRESSION
AB Chronic low-grade inflammation and excess mineralocorticoid receptor (MR) activation are well-known pathological conditions of metabolic syndrome (MetS). To elucidate the crosstalk between inflammation and MR signaling, we focused on serum/glucocorticoid-regulated kinase 1 (SGK1) in vascular endothelial cells. We treated human aortic endothelial cells (HAECs) with esaxerenone (ESX), a novel nonsteroidal highly selective MR antagonist, or spironolactone (SPL), a classic competitive MR antagonist, followed by stimulation with tumor necrosis factor (TNF)-alpha. ESX at therapeutic concentrations attenuated the long-term induction of TNF-alpha-stimulated inflammatory molecules in HAEC, whereas SPL had only a minor effect at 10 mu M. We found long-term TNF-alpha-stimulated induction of SGK1 mRNA and protein levels in HAEC and that ESX pretreatment significantly decreased SGK1 mRNA and protein levels at both the basal and the TNF-alpha-stimulated conditions, whereas SPL had no effect on SGK1 mRNA and protein levels. In addition, the TNF-alpha-induced nuclear factor kappa-light-chain-enhancer of activated B cell activity was suppressed by the treatment with ESX, and it was abrogated by SGK1 overexpression. These results indicated that ESX has direct anti-inflammatory effects in HAEC via the blocking of long-term TNF-alpha-induced SGK1 activation and that SGK1 could be a key molecule linking cytokine-induced vascular chronic inflammation and MR activation.
C1 [Yamamoto, Hiroyasu; Yoshida, Nao; Kihara, Shinji] Osaka Univ, Dept Biomed Informat, Div Hlth Sci, Grad Sch Med, 1-7 Yamada Oka, Suita, Osaka 5650871, Japan.
C3 The University of Osaka
RP Yamamoto, H (corresponding author), Osaka Univ, Dept Biomed Informat, Div Hlth Sci, Grad Sch Med, 1-7 Yamada Oka, Suita, Osaka 5650871, Japan.
EM yamamoto@sahs.med.osaka-u.ac.jp
RI Kihara, Shinji/GLU-1107-2022
FU Management Expenses Grants of Osaka University
FX Supported by a Management Expenses Grants of Osaka University.
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NR 67
TC 4
Z9 5
U1 0
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0160-2446
EI 1533-4023
J9 J CARDIOVASC PHARM
JI J. Cardiovasc. Pharmacol.
PD OCT
PY 2022
VL 80
IS 4
BP 583
EP 591
DI 10.1097/FJC.0000000000001316
PG 9
WC Cardiac & Cardiovascular Systems; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Pharmacology & Pharmacy
GA 5C6MN
UT WOS:000864372400013
PM 35900901
DA 2025-06-11
ER

PT J
AU Izadi, B
   Joulaei, H
   Lankarani, KB
   Tabrizi, R
   Taherifard, E
   Sadeghpour, A
   Vali, M
   Akbari, M
AF Izadi, Bahareh
   Joulaei, Hassan
   Lankarani, Kamran Bagheri
   Tabrizi, Reza
   Taherifard, Erfan
   Sadeghpour, Ali
   Vali, Mohebat
   Akbari, Maryam
TI The effect of green cardamom on blood pressure and inflammatory markers
   among patients with metabolic syndrome and related disorders: A
   systematic review and meta-analysis of randomized clinical trials
SO PHYTOTHERAPY RESEARCH
LA English
DT Review
DE blood pressure; cardamom; inflammatory markers; meta-analysis
ID OXIDATIVE STRESS; ESSENTIAL OILS; PATHOPHYSIOLOGY; HYPERTENSION;
   ANTIOXIDANT; PREVALENCE
AB Research shows that herbal spices, including seeds of Elettaria cardamomum, may exert beneficial effects on unhealthy metabolic status. This study is a systematic review of the effect of green cardamom in patients with metabolic syndrome and its related disorders. PubMed/Medline, Scopus, EMBASE, Web of Science, and Cochrane Library were searched to identify the relevant randomized clinical trials. The data were pooled using the random-effects model, and weighted mean difference (WMD) was considered as summary effect size. Of 625 clinical trials, eight reports with 595 patients (299 in intervention group and 296 in control group) were included. The findings indicated that green cardamom significantly decreased diastolic blood pressure (WMD: -0.91 mmHg, 95%CI; -1.19, -0.62), high-sensitivity C-reactive protein (WMD: -1.21 mg/L, 95%CI; -2.18, -0.24), interleukin 6 levels (WMD: -2.41 ng/L, 95%CI; -4.35, -0.47). However, cardamom supplementation did not significantly affect systolic blood pressure. This meta-analysis demonstrated that green cardamom could improve blood pressure control and exert antiinflammatory effects which could help patients with unhealthy metabolic profile better manage their health. Importantly, there were few eligible randomized trials with quite a low number of participants. Further prospective studies on larger sample sizes and longer duration of supplementation are warranted for its widespread use.
C1 [Izadi, Bahareh; Lankarani, Kamran Bagheri; Sadeghpour, Ali; Akbari, Maryam] Shiraz Univ Med Sci, Inst Hlth, Ctr Hlth Policy Res, Shiraz, Iran.
   [Joulaei, Hassan] Shiraz Univ Med Sci, Inst Hlth, Res Ctr, HIV AIDS, Shiraz, Iran.
   [Tabrizi, Reza] Fasa Univ Med Sci, Noncommun Dis Res Ctr, Fasa, Iran.
   [Tabrizi, Reza] Fasa Univ Med Sci, Valiasr Hosp, Clin Res Dev Unit, Fasa, Iran.
   [Taherifard, Erfan] Shiraz Univ Med Sci, Shiraz Sch Med, Shiraz, Iran.
   [Vali, Mohebat] Shiraz Univ Med Sci, Student Res Comm, Shiraz, Iran.
C3 Shiraz University of Medical Science; Shiraz University of Medical
   Science; Shiraz University of Medical Science; Shiraz University of
   Medical Science
RP Akbari, M (corresponding author), Ctr Hlth Policy Res, Inst Hlth, Sch Med, 8th Floor,Bldg 2,Zand Ave, Shiraz, Iran.
EM m.akbari45@yahoo.com
RI Vali, Mohebat/AAU-5817-2021; Akbari, Ali/G-6044-2016; Joulaei,
   Hassan/S-1034-2017; Izadi, Bahareh/KMX-7266-2024; Lankarani,
   Kamran/P-5336-2019; Taherifard, Erfan/N-8429-2018
OI Vali Esfahani, Mouhebat/0000-0001-7733-2116; Taherifard,
   Erfan/0000-0002-9101-0321
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NR 53
TC 2
Z9 3
U1 4
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0951-418X
EI 1099-1573
J9 PHYTOTHER RES
JI Phytother. Res.
PD FEB
PY 2023
VL 37
IS 2
BP 679
EP 688
DI 10.1002/ptr.7648
EA SEP 2022
PG 10
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 9C4RH
UT WOS:000862155200001
PM 36181264
DA 2025-06-11
ER

PT J
AU Guirro, M
   Gual-Grau, A
   Gibert-Ramos, A
   Alcaide-Hidalgo, JM
   Canela, N
   Arola, L
   Mayneris-Perxachs, J
AF Guirro, Maria
   Gual-Grau, Andreu
   Gibert-Ramos, Albert
   Alcaide-Hidalgo, Juan Maria
   Canela, Nuria
   Arola, Lluis
   Mayneris-Perxachs, Jordi
TI Metabolomics Elucidates Dose-Dependent Molecular Beneficial Effects of
   Hesperidin Supplementation in Rats Fed an Obesogenic Diet
SO ANTIOXIDANTS
LA English
DT Article
DE metabolic syndrome; cafeteria diet; polyphenols; citrus flavanones;
   hesperidin; metabolomics; metabolic phenotyping; gut microbiome
ID BLOOD-PRESSURE; ORANGE JUICE; URINARY METABOLITES; GLUCOSYL HESPERIDIN;
   INSULIN-RESISTANCE; BARIATRIC SURGERY; GUT MICROBIOTA; HYPERTENSION;
   POLYPHENOLS; OBESITY
AB Metabolic syndrome (MetS) is a global epidemic concern. Polyphenols are proposed as good candidates for its prevention, although their mechanisms are not fully understood. The gut microbiota seems to play a key role in polyphenol beneficial effects. Here, we assessed the effects of the citrus polyphenol hesperidin combining an untargeted metabolomics approach, which has an inherent potential to elucidate the host-microbiome interplay, with extensive anthropometric and biochemical characterizations and integrating metabolomics results with our previous 16S rRNA bacterial sequencing data. The rats were fed either a standard or an obesogenic cafeteria diet (CAF) for 17 weeks. After nine weeks, rats were supplemented with vehicle; low- (H1), or high- (H2) hesperidin doses. CAF animals developed MetS features. Hesperidin supplementation in CAF rats decreased the total cholesterol, LDL-C, and free fatty acids. The highest hesperidin dose also ameliorated blood pressure, insulin sensitivity, and decreased markers of arterial stiffness and inflammation. Metabolomics revealed an improvement of the lipidomic profile, decreases in circulating amino acids, and lower excretions of inflammation- and oxidative stress-related metabolites. Bacteroidaceae increases in the CAF-H2 group paralleled higher excretions of microbial-derived metabolites. Overall, our results provide detailed insights into the molecular effects of hesperidin on MetS and suggest that it is a promising prebiotic for the treatment of MetS and related conditions.
C1 [Guirro, Maria; Canela, Nuria; Arola, Lluis; Mayneris-Perxachs, Jordi] Eurecat, Technol Unit Omics Sci, Ctr Tecnol Catalunya, Reus 43204, Spain.
   [Guirro, Maria; Gual-Grau, Andreu; Gibert-Ramos, Albert; Arola, Lluis] Univ Rovira & Virgili, Nutrigen Res Grp, Dept Biochem & Biotechnol, Marcel Li Domingo 1, E-43007 Tarragona, Spain.
   [Alcaide-Hidalgo, Juan Maria; Arola, Lluis; Mayneris-Perxachs, Jordi] Eurecat, Technol Unit Nutr & Hlth, Ctr Tecnol Catalunya, Reus 43204, Spain.
   [Mayneris-Perxachs, Jordi] Dr Josep Trueta Univ Hosp, Dept Diabet Endocrinol & Nutr, Girona 17007, Spain.
   [Mayneris-Perxachs, Jordi] Girona Biomed Res Inst IDIBGI, Girona 17007, Spain.
   [Mayneris-Perxachs, Jordi] Inst Salud Carlos III, Ctr Physiopathol Obes & Nutr CIBERobn, Madrid 28029, Spain.
C3 Universitat Rovira i Virgili; Universitat de Girona; Girona University
   Hospital Dr. Josep Trueta; Universitat de Girona; Girona University
   Hospital Dr. Josep Trueta; Institut d'Investigacio Biomedica de Girona
   (IDIBGI); CIBER - Centro de Investigacion Biomedica en Red; CIBEROBN;
   Instituto de Salud Carlos III
RP Arola, L; Mayneris-Perxachs, J (corresponding author), Eurecat, Technol Unit Omics Sci, Ctr Tecnol Catalunya, Reus 43204, Spain.; Arola, L (corresponding author), Univ Rovira & Virgili, Nutrigen Res Grp, Dept Biochem & Biotechnol, Marcel Li Domingo 1, E-43007 Tarragona, Spain.; Arola, L; Mayneris-Perxachs, J (corresponding author), Eurecat, Technol Unit Nutr & Hlth, Ctr Tecnol Catalunya, Reus 43204, Spain.; Mayneris-Perxachs, J (corresponding author), Inst Salud Carlos III, Ctr Physiopathol Obes & Nutr CIBERobn, Madrid 28029, Spain.
EM maria.guirro@eurecat.org; andreu.gual@urv.cat; Albert.gibert@urv.cat;
   juanmaria.alcaide@eurecat.org; nuria.canela@eurecat.org;
   lluis.arola@ce.eurecat.org; jmayneris@idibgi.org
RI Mayneris-Perxachs, Jordi/AAG-7724-2020; MAYNERIS-PERXACHS,
   JORDI/B-2589-2018; Arola, Lluis/C-6074-2011; Canela, Nuria/I-5401-2015;
   Gibert Ramos, Albert/F-4438-2017
OI MAYNERIS-PERXACHS, JORDI/0000-0003-3788-3815; Alcaide Hidalgo, Juan
   Maria/0000-0001-5705-7807; Arola, Lluis/0000-0003-2767-1974; Gual-Grau,
   Andreu/0000-0002-8901-3582; Canela, Nuria/0000-0003-0261-2396; Gibert
   Ramos, Albert/0000-0002-5987-1164
FU 7th Framework Programme of the European Union; Agency for Business
   Competitiveness of the Government of Catalonia (ACCIO) under the
   TECNOspring programme [TECSPR14-2-0001]
FX This research was co-funded by the 7th Framework Programme of the
   European Union and the Agency for Business Competitiveness of the
   Government of Catalonia (ACCIO) under the TECNOspring programme granted
   to J.M.-P. (TECSPR14-2-0001).
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NR 65
TC 27
Z9 28
U1 0
U2 26
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD JAN
PY 2020
VL 9
IS 1
AR 79
DI 10.3390/antiox9010079
PG 19
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA KJ6EF
UT WOS:000512151700023
PM 31963315
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU He, LY
   Li, Y
   Niu, SQ
   Bai, J
   Liu, SJ
   Guo, JL
AF He, Li-Ying
   Li, Yong
   Niu, Shu-Qi
   Bai, Jing
   Liu, Si-Jing
   Guo, Jin-Lin
TI Polysaccharides from natural resource: ameliorate type 2 diabetes
   mellitus via regulation of oxidative stress network
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Review
DE diabetes mellitus; natural polysaccharide; oxidative stress; metabolism;
   mechanism
ID HYPOGLYCEMIC ACTIVITY; OPHIOPOGON-JAPONICUS; INSULIN-RESISTANCE;
   IN-VITRO; ANTIOXIDANT; GLUCOSE; CELLS; RATS; INFLAMMATION; DYSFUNCTION
AB Diabetes mellitus (DM) is a group of metabolic diseases characterized by hyperglycemia that can occur in children, adults, elderly people, and pregnant women. Oxidative stress is a significant adverse factor in the pathogenesis of DM, especially type 2 diabetes mellitus (T2DM), and metabolic syndrome. Natural polysaccharides are macromolecular compounds widely distributed in nature. Some polysaccharides derived from edible plants and microorganisms were reported as early as 10 years ago. However, the structural characterization of polysaccharides and their therapeutic mechanisms in diabetes are relatively shallow, limiting the application of polysaccharides. With further research, more natural polysaccharides have been reported to have antioxidant activity and therapeutic effects in diabetes, including plant polysaccharides, microbial polysaccharides, and polysaccharides from marine organisms and animals. Therefore, this paper summarizes the natural polysaccharides that have therapeutic potential for diabetes in the past 5 years, elucidating their pharmacological mechanisms and identified primary structures. It is expected to provide some reference for the application of polysaccharides, and provide a valuable resource for the development of new diabetic drugs.
C1 [He, Li-Ying; Li, Yong; Guo, Jin-Lin] Chengdu Univ Tradit Chinese Med, Coll Pharm, Key Lab Characterist Chinese Med Resources Southwe, Chengdu, Peoples R China.
   [Niu, Shu-Qi; Bai, Jing; Liu, Si-Jing; Guo, Jin-Lin] Chengdu Univ Tradit Chinese Med, Coll Med Technol, Chengdu, Peoples R China.
   [Niu, Shu-Qi; Liu, Si-Jing; Guo, Jin-Lin] Chongqing Key Lab Sichuan Chongqing Co Construct D, Chongqing, Peoples R China.
C3 Chengdu University of Traditional Chinese Medicine; Chengdu University
   of Traditional Chinese Medicine
RP Guo, JL (corresponding author), Chengdu Univ Tradit Chinese Med, Coll Pharm, Key Lab Characterist Chinese Med Resources Southwe, Chengdu, Peoples R China.; Liu, SJ; Guo, JL (corresponding author), Chengdu Univ Tradit Chinese Med, Coll Med Technol, Chengdu, Peoples R China.; Liu, SJ; Guo, JL (corresponding author), Chongqing Key Lab Sichuan Chongqing Co Construct D, Chongqing, Peoples R China.
EM liusijing@cdutcm.edu.cn; guo596@cdutcm.edu.cn
RI Niu, Shuqi/HTN-9888-2023; he, liying/GZK-4618-2022; Li,
   Yong/AAR-7326-2021
OI He, Liying/0000-0002-1674-8174
FU National Natural Sciences Foundation of China [81872959, 81373920,
   30801522, 82003900]; "Xinglin Scholar" Talent Research Promotion Plan of
   Chengdu University of Traditional Chinese Medicine [ZYTS2019022]; Young
   Science and Technology Innovation Team of Sichuan Province
   [2019CXTD0055]
FX This work was supported by the National Natural Sciences Foundation of
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   Talent Research Promotion Plan of Chengdu University of Traditional
   Chinese Medicine (No. ZYTS2019022). Young Science and Technology
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NR 145
TC 9
Z9 9
U1 10
U2 74
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD JUL 11
PY 2023
VL 14
AR 1184572
DI 10.3389/fphar.2023.1184572
PG 20
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA N3NP6
UT WOS:001036123500001
PM 37497112
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Chakravarthy, MV
   Neuschwander-Tetri, BA
AF Chakravarthy, Manu V.
   Neuschwander-Tetri, Brent A.
TI The metabolic basis of nonalcoholic steatohepatitis
SO ENDOCRINOLOGY DIABETES & METABOLISM
LA English
DT Review
DE insulin resistance; lipotoxic stress; metabolic inflexibility;
   mitochondrial dysfunction
ID FATTY LIVER-DISEASE; HEPATIC INSULIN-RESISTANCE; ENDOPLASMIC-RETICULUM
   STRESS; MOLECULAR-MECHANISMS; FIBROSIS STAGE; CARDIOVASCULAR-DISEASE;
   SERIES LIPOTOXICITY; CYTOCHROME-P450 2E1; LIPID HOMEOSTASIS;
   PHYSICAL-ACTIVITY
AB Nonalcoholic fatty liver disease (NAFLD) is a major cause of chronic liver disease and is associated with significant morbidity and mortality worldwide, with a high incidence in Western countries and non-Western countries that have adopted a Western diet. NAFLD is commonly associated with components of the metabolic syndrome, type 2 diabetes mellitus and cardiovascular disease, suggesting a common mechanistic basis. An inability to metabolically handle free fatty acid overload-metabolic inflexibility-constitutes a core node for NAFLD pathogenesis, with resulting lipotoxicity, mitochondrial dysfunction and cellular stress leading to inflammation, apoptosis and fibrogenesis. These responses can lead to the histological phenotype of nonalcoholic steatohepatitis (NASH) with varying degrees of fibrosis, which can progress to cirrhosis. This perspective review describes the key cellular and molecular mechanisms of NAFLD and NASH, namely an excessive burden of carbohydrates and fatty acids that contribute to lipotoxicity resulting in hepatocellular injury and fibrogenesis. Understanding the extrahepatic dysmetabolic contributors to NASH is crucial for the development of safe, effective and durable treatment approaches for this increasingly common disease.
C1 [Chakravarthy, Manu V.] Axcella Hlth Inc, Cambridge, MA USA.
   [Neuschwander-Tetri, Brent A.] St Louis Univ, St Louis, MO USA.
C3 Saint Louis University
RP Chakravarthy, MV (corresponding author), Axcella Health Inc, 840 Mem Dr, Cambridge, MA 02139 USA.
EM mchakravarthy@axcellahealth.com
RI Chakravarthy, Manu/AAD-7553-2021; Neuschwander-Tetri,
   Brent/IST-8116-2023
OI Neuschwander-Tetri, Brent/0000-0002-8520-7398; Chakravarthy,
   Manu/0000-0002-3699-150X
FU Fishawack Communications Inc; Axcella Health, Inc
FX Editing assistance was provided by Caryne Craige, PhD, of Fishawack
   Communications Inc; funding for this assistance was provided by Axcella
   Health, Inc
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NR 130
TC 58
Z9 65
U1 0
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
EI 2398-9238
J9 ENDOCRIN DIAB METAB
JI Endocrinol. Diabetes Metab.
PD OCT
PY 2020
VL 3
IS 4
AR e00112
DI 10.1002/edm2.112
PG 13
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA VM2XX
UT WOS:000993474800004
PM 33102794
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Liu, PK
   Chiu, TY
   Wang, NK
   Levi, SR
   Tsai, MJ
AF Liu, Pei-Kang
   Chiu, Tzu-Yu
   Wang, Nan-Kai
   Levi, Sarah R.
   Tsai, Ming-Ju
TI Ocular Complications of Obstructive Sleep Apnea
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Review
DE obstructive sleep apnea; sleep-disordered breathing; nocturnal hypoxia;
   eye; complications; oxidative stress; inflammation; sympathetic
   activation
ID POSITIVE AIRWAY PRESSURE; CENTRAL SEROUS CHORIORETINOPATHY; DIABETIC
   MACULAR EDEMA; RETINAL VEIN OCCLUSION; FIBER LAYER THICKNESS; FLOPPY
   EYELID SYNDROME; RISK-FACTORS; INTRAOCULAR-PRESSURE; METABOLIC SYNDROME;
   OXIDATIVE STRESS
AB Obstructive sleep apnea (OSA), the most common form of sleep-disordered breathing, is characterized by repetitive episodes of paused breathing during sleep, which in turn induces transient nocturnal hypoxia and hypercapnia. The high prevalence of OSA and its associated health consequences place a heavy burden on the healthcare system. In particular, the consequent episodic oxygenic desaturation/reoxygenation series and arousals from sleep in patients with OSA have the potential to trigger oxidative stress, elevated systemic inflammatory responses, and autonomic dysfunction with sympathetic activation. Given these adverse side-effects, OSA is highly correlated to many eye diseases that are common in everyday ophthalmic practices. Some of these ocular consequences are reversible, but they may permanently threaten a patient's vision if not treated appropriately. Here, this article seeks to review the ocular consequences and potential pathophysiologic associations in patients with OSA. Understanding these OSA-related eye diseases may help clinicians provide comprehensive care to their patients.
C1 [Liu, Pei-Kang; Chiu, Tzu-Yu] Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Ophthalmol, Kaohsiung 807, Taiwan.
   [Liu, Pei-Kang; Chiu, Tzu-Yu] Kaohsiung Med Univ, Coll Med, Sch Med, Kaohsiung 807, Taiwan.
   [Liu, Pei-Kang] Natl Sun Yat Sen Univ, Inst Biomed Sci, Kaohsiung 804, Taiwan.
   [Liu, Pei-Kang; Wang, Nan-Kai; Levi, Sarah R.] Columbia Univ, Edward S Harkness Eye Inst, Dept Ophthalmol, New York, NY 10032 USA.
   [Tsai, Ming-Ju] Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Internal Med, Div Pulm & Crit Care Med, Kaohsiung 807, Taiwan.
   [Tsai, Ming-Ju] Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Sleep Disorders Ctr, Kaohsiung 807, Taiwan.
   [Tsai, Ming-Ju] Kaohsiung Med Univ, Coll Med, Dept Resp Care, Kaohsiung 807, Taiwan.
   [Tsai, Ming-Ju] Kaohsiung Med Univ, Coll Med, Grad Inst Clin Med, Kaohsiung 807, Taiwan.
C3 Kaohsiung Medical University; Kaohsiung Medical University Hospital;
   Kaohsiung Medical University; National Sun Yat Sen University; Columbia
   University; Kaohsiung Medical University; Kaohsiung Medical University
   Hospital; Kaohsiung Medical University; Kaohsiung Medical University
   Hospital; Kaohsiung Medical University; Kaohsiung Medical University
RP Tsai, MJ (corresponding author), Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Internal Med, Div Pulm & Crit Care Med, Kaohsiung 807, Taiwan.; Tsai, MJ (corresponding author), Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Sleep Disorders Ctr, Kaohsiung 807, Taiwan.; Tsai, MJ (corresponding author), Kaohsiung Med Univ, Coll Med, Dept Resp Care, Kaohsiung 807, Taiwan.; Tsai, MJ (corresponding author), Kaohsiung Med Univ, Coll Med, Grad Inst Clin Med, Kaohsiung 807, Taiwan.
EM aleckliu418@gmail.com; kathychiu77924@hotmail.com;
   wang.nankai@gmail.com; Slevi@wesleyan.edu; SiegfriedTsai@gmail.com
RI Tsai, Ming-Ju/D-5566-2011; Wang, Nan-Kai/D-6608-2011
OI Liu, Pei-Kang/0000-0002-6417-4363; Wang, Nan-Kai/0000-0002-6277-9879;
   Levi, Sarah/0000-0002-6503-1778; Chiu, Tzu-Yu/0000-0001-8442-924X
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NR 183
TC 15
Z9 18
U1 0
U2 23
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD AUG
PY 2021
VL 10
IS 15
AR 3422
DI 10.3390/jcm10153422
PG 22
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA TW0GT
UT WOS:000682090800001
PM 34362205
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Fotouhi, S
   Yavari, A
   Bagheri, AR
   Askari, VR
   Gholami, Y
   Rahimi, VB
AF Fotouhi, Soroush
   Yavari, Aida
   Bagheri, Amir Reza
   Askari, Vahid Reza
   Gholami, Yazdan
   Rahimi, Vafa Baradaran
TI Exploring the promising impacts of naringin and its aglycone constituent
   naringenin as major citrus flavonoids on diabetes and its complications
SO JOURNAL OF FUNCTIONAL FOODS
LA English
DT Article
DE Naringin; Naringenin; Diabetes mellitus; Inflammation; Oxidative stress
ID AMELIORATES COGNITIVE DEFICITS; OXIDATIVE STRESS; PPAR-GAMMA; IN-VITRO;
   METABOLIC SYNDROME; HEPATIC STEATOSIS; INDUCED INJURIES; UP-REGULATION;
   RAT MODEL; GLUCOSE
AB Due to their capacity to fight apoptosis, inflammation, and oxidative stress, naringin and its aglycone naringenin are considered valuable therapeutic agents for diabetes mellitus (DM). By examining clinical, in vitro, and in vivo studies found from inception until July 2024 on major electronic databases, we explored the pharmacological activities of naringin and naringenin in treating DM and associated risks. Naringin and naringenin improved insulin sensitivity, glucose metabolism, and insulin resistance by activating glucose transporter (GLUT)-4, and peroxisome proliferator-activated receptor (PPAR)-gamma. They also possessed antioxidant and anti-inflammatory impacts through regulating mitogen-activated protein kinases (MAPK), nuclear factor kappa B (NF-kappa B), and Nrf2 signaling pathways. The obtained data emphasizes their role in protecting against heart, neuropathy, nephropathy, gastrointestinal tract, testicles, and skin diabetic complications. Naringin and naringenin could be developed as novel therapeutic options for treating DM, and the knowledge acquired from this review could be a valuable tool for future research projects.
C1 [Fotouhi, Soroush; Yavari, Aida; Bagheri, Amir Reza; Gholami, Yazdan] Mashhad Univ Med Sci, Student Res Comm, Fac Med, Mashhad, Iran.
   [Askari, Vahid Reza] Mashhad Univ Med Sci, Pharmacol Res Ctr Med Plants, Mashhad, Iran.
   [Rahimi, Vafa Baradaran] Mashhad Univ Med Sci, Fac Med, Dept Cardiovasc Dis, Azadi Sq,Vakil Abad Highway, Mashhad, Iran.
C3 Mashhad University of Medical Sciences; Mashhad University of Medical
   Sciences; Mashhad University of Medical Sciences
RP Rahimi, VB (corresponding author), Mashhad Univ Med Sci, Fac Med, Dept Cardiovasc Dis, Azadi Sq,Vakil Abad Highway, Mashhad, Iran.
EM baradaranrv@mums.ac.ir
RI Askari, Vahid Reza/ABB-8991-2020; Baradaran Rahimi, Vafa/AAR-4523-2021
OI Baradaran Rahimi, Vafa/0000-0003-2320-5095
FU Mashhad University of Medical Sci-ences, Mashhad, Iran
FX This study was supported by Mashhad University of Medical Sci-ences,
   Mashhad, Iran.
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NR 147
TC 1
Z9 1
U1 3
U2 3
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1756-4646
EI 2214-9414
J9 J FUNCT FOODS
JI J. Funct. Food.
PD JAN
PY 2025
VL 124
AR 106643
DI 10.1016/j.jff.2024.106643
EA DEC 2024
PG 25
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA R9R9Q
UT WOS:001394738600001
OA gold
DA 2025-06-11
ER

PT J
AU Wang, M
   Zhang, BQ
   Ma, S
   Xu, Y
   Zhao, DH
   Zhang, JS
   Li, CJ
   Zhou, X
   Zheng, LW
AF Wang, Min
   Zhang, Bo-Qi
   Ma, Shuai
   Xu, Ying
   Zhao, Dong-Hai
   Zhang, Jing-Shun
   Li, Chun-Jin
   Zhou, Xu
   Zheng, Lian-Wen
TI Broadening horizons: the role of ferroptosis in polycystic ovary
   syndrome
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Review
DE ferroptosis; polycystic ovary syndrome; oxidative stress; metabolic
   disorders; expression; biomarkers
ID BODY IRON STORES; OXIDATIVE STRESS; CELL-DEATH; PROMOTES FERROPTOSIS;
   GRANULOSA-CELLS; INSULIN-RESISTANCE; SYSTEM X(C)(-); CYSTINE/GLUTAMATE
   ANTIPORTER; MITOCHONDRIAL DYSFUNCTION; METABOLIC SYNDROME
AB Polycystic ovarian syndrome (PCOS) is a common heterogeneous reproductive endocrine metabolic disorder in women of reproductive age characterized by clinical and biochemical hyperandrogenemia, ovulation disorders, and polycystic ovarian morphology. Ferroptosis is a novel type of cell death driven by iron accumulation and lipid peroxidation. Ferroptosis plays a role in maintaining redox balance, iron metabolism, lipid metabolism, amino acid metabolism, mitochondrial activity, and many other signaling pathways linked to diseases. Iron overload is closely related to insulin resistance, decreased glucose tolerance, and the occurrence of diabetes mellitus. There is limited research on the role of ferroptosis in PCOS. Patients with PCOS have elevated levels of ferritin and increased reactive oxygen species in ovarian GCs. Studying ferroptosis in PCOS patients is highly important for achieving personalized treatment. This article reviews the progress of research on ferroptosis in PCOS, introduces the potential connections between iron metabolism abnormalities and oxidative stress-mediated PCOS, and provides a theoretical basis for diagnosing and treating PCOS.
C1 [Wang, Min; Ma, Shuai; Xu, Ying; Zhang, Jing-Shun; Zheng, Lian-Wen] Second Hosp Jilin Univ, Dept Obstet & Gynecol, Changchun, Peoples R China.
   [Zhang, Bo-Qi; Li, Chun-Jin; Zhou, Xu] Jilin Univ, Coll Anim Sci, Changchun, Peoples R China.
   [Zhao, Dong-Hai] Jilin Med Coll, Dept Pathol, Jilin, Peoples R China.
C3 Jilin University; Jilin University; Jilin Medical University
RP Zheng, LW (corresponding author), Second Hosp Jilin Univ, Dept Obstet & Gynecol, Changchun, Peoples R China.; Li, CJ; Zhou, X (corresponding author), Jilin Univ, Coll Anim Sci, Changchun, Peoples R China.
EM li_chunjin@jlu.edu.cn; zxu@jlu.edu.cn; davezheng@sohu.com
RI Zhang, Jingshun/H-9877-2013
FU Natural Science Foundation of Jilin Province [YDZJ202301ZYTS434,
   YDZJ202201ZYTS007]; Jilin Provincial Development and Reform Commission
   Project [2023C037-4]
FX The author(s) declare financial support was received for the research,
   authorship, and/or publication of this article. This study was supported
   by the Natural Science Foundation of Jilin Province (NO
   YDZJ202301ZYTS434, NO YDZJ202201ZYTS007) and the Jilin Provincial
   Development and Reform Commission Project (2023C037-4).
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NR 173
TC 5
Z9 5
U1 7
U2 16
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD AUG 2
PY 2024
VL 15
AR 1390013
DI 10.3389/fendo.2024.1390013
PG 14
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA C7F6M
UT WOS:001290994800001
PM 39157678
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Martínez, R
   Kapravelou, G
   López-Chaves, C
   Cáceres, E
   Coll-Risco, I
   Sánchez-González, C
   Llopis, J
   Arrebola, F
   Galisteo, M
   Aranda, P
   López-Jurado, M
   Porres, JM
AF Martinez, Rosario
   Kapravelou, Garyfallia
   Lopez-Chaves, Carlos
   Caceres, Elena
   Coll-Risco, Irene
   Sanchez-Gonzalez, Cristina
   Llopis, Juan
   Arrebola, Francisco
   Galisteo, Milagros
   Aranda, Pilar
   Lopez-Jurado, Maria
   Porres, Jesus M.
TI Aerobic interval exercise improves renal functionality and affects
   mineral metabolism in obese Zucker rats
SO AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
LA English
DT Article
DE aerobic interval training; diabetic nephropathy; glomerulosclerosis;
   mineral metabolism; Zucker rat
ID CHRONIC KIDNEY-DISEASE; URIC-ACID; INSULIN-RESISTANCE;
   DIABETES-MELLITUS; OXIDATIVE STRESS; STONE FORMATION; BONE-STRUCTURE;
   MODEL; ASSOCIATION; MARKERS
AB Obesity, metabolic syndrome. and renal injury are considered risk factors for type 2 diabetes, as well as kidney disease. Functional and structural changes in the kidney as consequence of obesity and metabolic syndrome may lead to impaired mineral metabolism in what is known as chronic kidney disease-mineral and bone disorder. Lifestyle interventions such as physical activity are good strategies to manage these pathologies and therefore, prevent the loss of kidney functionality and related complications in mineral metabolism. In this study. we have used 40 male Zucker rats that were randomly allocated into four different experimental groups, two of them (an obese and a lean one) performed an aerobic interval training protocol. and the other two groups were sedentary. At the end of the experimental period (8 wk), urine, plasma, and femur were collected for biochemical and mineral composition analysis, whereas the kidney was processed for histological studies. The obese rats exhibited albuminuria, glomerulosclemsis, and hypertrophy in glomeruli and renal tubule in some areas, together with alterations in mineral content of plasma but not of femur. The training protocol prevented the generation of albuminuria and glomerttlosclerosis. showing a significant action on plasma and bone mineral levels. Therefore, the specific training protocol used in this study was able to prevent the development of diabetic nephropathy and affected the metabolism of certain minerals.
C1 [Martinez, Rosario; Kapravelou, Garyfallia; Lopez-Chaves, Carlos; Caceres, Elena; Coll-Risco, Irene; Sanchez-Gonzalez, Cristina; Llopis, Juan; Aranda, Pilar; Lopez-Jurado, Maria; Porres, Jesus M.] Univ Granada, Ctr Res Sport & Hlth, Ctr Biomed Res, Inst Nutr & Food Technol,Dept Physiol, Granada, Spain.
   [Arrebola, Francisco] Univ Granada, Ctr Biomed Res, Inst Neurosci, Dept Histol, Granada, Spain.
   [Galisteo, Milagros] Univ Granada, Sch Pharm, Dept Pharmacol, Campus Univ Cartuja, Granada, Spain.
C3 University of Granada; University of Granada; University of Granada
RP Porres, JM (corresponding author), Univ Granada, Ctr Biomed Res, Inst Nutr & Food Technol, Avda Conocimiento S-N, Granada 18100, Spain.
EM jmporres@ugr.es
RI Coll Risco, Irene/GZN-1623-2022; Kapravelou, Garyfallia/K-8635-2017;
   LLOPIS, juan/JQV-8992-2023; Arrebola Vargas, Francisco/L-9108-2014;
   Sanchez Gonzalez, Cristina/Q-6219-2017; Martinez, Rosario/K-7712-2017;
   Porres Foulquie, Jesus Maria/B-6442-2018
OI Sanchez Gonzalez, Cristina/0000-0002-1044-4858; Martinez,
   Rosario/0000-0003-2032-1621; Porres Foulquie, Jesus
   Maria/0000-0001-5657-0764; Coll-Risco, Irene/0000-0003-2176-0538
FU Junta de Andalucia (Spain) [P09-AGR-4658]; Ministry of Economy and
   Competitiveness (MINECO, Spain); European Union [AGL2013-43247-R,
   DEP2014-58296-R]; European Regional Development Fund (FEDER) program
FX This study was funded by Junta de Andalucia Grant P09-AGR-4658 (Spain).
   The Ministry of Economy and Competitiveness (MINECO, Spain) and the
   European Union through Projects AGL2013-43247-R and DEP2014-58296-R and
   the The European Regional Development Fund (FEDER) program,
   respectively, are acknowledged.
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NR 62
TC 10
Z9 11
U1 3
U2 16
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 1931-857X
EI 1522-1466
J9 AM J PHYSIOL-RENAL
JI Am. J. Physiol.-Renal Physiol.
PD JAN
PY 2019
VL 316
IS 1
BP F90
EP F100
DI 10.1152/ajprenal.00356.2018
PG 11
WC Physiology; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology; Urology & Nephrology
GA HH3JQ
UT WOS:000455616200009
PM 30303711
DA 2025-06-11
ER

PT J
AU Diaz, A
   Escobedo, C
   Treviño, S
   Chávez, R
   Lopez-Lopez, G
   Moran, C
   Guevara, J
   Venegas, B
   Muñoz-Arenas, G
AF Diaz, Alfonso
   Escobedo, Claudia
   Trevino, Samuel
   Chavez, Raul
   Lopez-Lopez, Gustavo
   Moran, Carolina
   Guevara, Jorge
   Venegas, Berenice
   Munoz-Arenas, Guadalupe
TI Metabolic Syndrome Exacerbates the Recognition Memory Impairment and
   Oxidative-Inflammatory Response in Rats with an Intrahippocampal
   Injection of Amyloid Beta 1-42
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Article
ID HIGH-FAT DIET; NECROSIS-FACTOR-ALPHA; ALZHEIMERS-DISEASE;
   INSULIN-RESISTANCE; TEMPORAL CORTEX; ACTIVATION; GLUCOSE; BRAIN;
   NEUROINFLAMMATION; NEURODEGENERATION
AB An important worldwide health problem as the result of current lifestyle is metabolic syndrome (MS). It has been shown that MS induced by a high-calorie diet (HCD) in rats produces cognitive deterioration in the novel object recognition test (NORt) and decreases synaptic connections and dendritic order in the hippocampus and temporal cortex. However, it is unknown whether MS induced by an HCD participates in the cognitive process observed with the injection of A beta(1-42) into the hippocampus of rats as a model of Alzheimer disease (AD). The induction of MS in rats produces a deterioration in NORt; however, rats with MS injected with A beta(1-42) show a major deterioration in the cognitive process. This event could be explained by the increment in the oxidative stress in both cases studied (MS and A beta(1-42)): together, the hippocampus and temporal cortex produce an enhancer effect. In the same way, we observed an increment in interleukin-1 beta, TNF-alpha, and GFAP, indicative of exacerbated inflammatory processes by the combination of MS and A beta(1-42). We can conclude that MS might play a key role in the apparition and development of cognitive disorders, including AD. We propose that metabolic theory is important to explain the apparition of cognitive diseases.
C1 [Diaz, Alfonso; Escobedo, Claudia; Trevino, Samuel; Lopez-Lopez, Gustavo; Munoz-Arenas, Guadalupe] Benemerita Univ Autonoma Puebla, Fac Ciencias Quim, Puebla, PUE, Mexico.
   [Chavez, Raul; Guevara, Jorge] Univ Nacl Autonoma Mexico, Fac Med, Dept Bioquim, Mexico City, DF, Mexico.
   [Moran, Carolina] Benemerita Univ Autonoma Puebla, Inst Ciencias, Dept Biol & Toxicol Reprod, Puebla, PUE, Mexico.
   [Venegas, Berenice] Benemerita Univ Autonoma Puebla, Fac Ciencias Biol, Puebla, PUE, Mexico.
C3 Benemerita Universidad Autonoma de Puebla; Universidad Nacional Autonoma
   de Mexico; Benemerita Universidad Autonoma de Puebla; Benemerita
   Universidad Autonoma de Puebla
RP Diaz, A (corresponding author), Benemerita Univ Autonoma Puebla, Fac Ciencias Quim, Puebla, PUE, Mexico.
EM alfonso.diaz@correo.buap.mx; gmunozarenas@gmail.com
RI MORÁN, CAROLINA/AAF-4007-2019; Venegas, Berenice/AAG-4048-2021
OI Munoz-Arenas, Guadalupe/0000-0002-7622-5308; MORAN,
   CAROLINA/0000-0002-2023-2242; Diaz, Alfonso/0000-0003-4092-6636; VENEGAS
   MENESES, BERENICE/0000-0001-9009-655X
FU VIEP-BUAP [DIFA-NAT17-I, MAMG-NAT17-I, TRMS-NAT17-I]; PRODEP
   [511-6/17-8017, BUAP-PTC-550, BUAP-PTC-577]; PAPIIT-UNAM [IN214117]
FX The funding for this study was provided by grants from the VIEP-BUAP
   (DIFA-NAT17-I, MAMG-NAT17-I, and TRMS-NAT17-I) and PRODEP (511-6/17-8017
   and BUAP-PTC-550 to Guadalupe Munoz-Arenas, and BUAP-PTC-577 to Berenice
   Venegas, and PAPIIT-UNAM (IN214117) to Jorge Guevara). The authors want
   to thank Dr. Francisco Ramos Collazo for his help with the animal care.
   Alfonso Diaz, Samuel Trevino, Jorge Guevara, Berenice Venegas, Raul
   Chavez, Guadalupe Munoz-Arenas, Gustavo Lopez-Lopez, and Carolina Moran
   acknowledge the "Sistema Nacional de Investigadores" of Mexico for the
   membership. Thanks are due to Professor Thomas Edwards, Ph.D., for
   editing the English language text.
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NR 50
TC 23
Z9 23
U1 0
U2 3
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PY 2018
VL 2018
AR 1358057
DI 10.1155/2018/1358057
PG 13
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA GQ2XJ
UT WOS:000441522700001
PM 30154946
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Plowman, TJ
   Shah, MH
   Fernandez, E
   Christensen, H
   Aiges, M
   Ramana, KV
AF Plowman, Trevor J.
   Shah, Mujtaba H.
   Fernandez, Emely
   Christensen, Hannah
   Aiges, Myia
   Ramana, Kota V.
TI Role of Innate Immune and Inflammatory Responses in the Development of
   Secondary Diabetic Complications
SO CURRENT MOLECULAR MEDICINE
LA English
DT Review
DE Diabetes; hyperglycemia; innate immunity; inflammation; oxidative
   stress; glucose
ID NF-KAPPA-B; GLYCATION END-PRODUCTS; TOLL-LIKE RECEPTORS; KINASE-C
   ISOFORMS; NLRP3 INFLAMMASOME; ANTIINFLAMMATORY AGENTS; METABOLIC
   SYNDROME; KIDNEY-DISEASE; ACTIVATION; MELLITUS
AB Increased hyperglycemia due to uncontrolled diabetes is the major cause of secondary diabetic complications such as retinopathy, neuropathy, nephropathy, and cardiovascular diseases. Although it is well known that increased oxidative stress, activation of the polyol pathway, protein kinase C and increased generation of advanced glycation end products could contribute to the development of diabetic complications, recent studies implicated the role of innate immunity and its related inflammatory responses in the pathophysiology of secondary diabetic complications. Increased activation of oxidative stress signaling could regulate NLRP3 inflammasome-mediated innate immune responses as well as NF-kappa B signalosome-mediated pro-inflammatory responses. This review article focused on the pathogenic role of innate immune and inflammatory responses in the progression of hyperglycemia-induced secondary diabetic complications. Specifically, we discussed in depth how deregulated innate immune and inflammatory responses could lead to an aggravated release of cytokines, chemokines, and growth factors resulting in the development of various secondary complications of diabetes.
C1 [Plowman, Trevor J.; Shah, Mujtaba H.; Fernandez, Emely; Christensen, Hannah; Aiges, Myia; Ramana, Kota V.] Noorda Coll Osteopath Med, Dept Biomed Sci, Provo, UT 84606 USA.
   [Ramana, Kota V.] Noorda Coll Osteopath Med, Dept Biomed Sci, 1712 East Bay Blvd,Bldg 5, Provo, UT 84606 USA.
RP Ramana, KV (corresponding author), Noorda Coll Osteopath Med, Dept Biomed Sci, 1712 East Bay Blvd,Bldg 5, Provo, UT 84606 USA.
EM karamana@noordacom.org
RI Ramana, Kota/C-5460-2012
OI Ramana, Kota/0000-0001-6502-7800; Shah, Mujtaba/0000-0002-2442-4874
FU Declared none.
FX Declared none.
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NR 139
TC 10
Z9 10
U1 2
U2 15
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1566-5240
EI 1875-5666
J9 CURR MOL MED
JI Curr. Mol. Med.
PY 2023
VL 23
IS 9
BP 901
EP 920
DI 10.2174/1566524023666220922114701
PG 20
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA T8CH1
UT WOS:001080201200006
PM 36154569
DA 2025-06-11
ER

PT J
AU Lee, CY
   Chen, HC
   Lin, HW
   Huang, JY
   Chao, SC
   Yeh, CB
   Lin, HY
   Yang, SF
AF Lee, Chia-Yi
   Chen, Hung-Chi
   Lin, Hui-Wen
   Huang, Jing-Yang
   Chao, Shih-Chun
   Yeh, Chao-Bin
   Lin, Hung-Yu
   Yang, Shun-Fa
TI Blepharitis as an early sign of metabolic syndrome: a nationwide
   population-based study
SO BRITISH JOURNAL OF OPHTHALMOLOGY
LA English
DT Article
ID MEIBOMIAN GLAND DYSFUNCTION; OXIDATIVE STRESS; DRY EYE; METAANALYSIS;
   STROKE; RISK
AB Background To investigate the relationship between blepharitis and metabolic syndrome (MetS) by using the Longitudinal Health Insurance Database (LHID) of Taiwan.
   Methods This retrospective cohort study was conducted using data collected from the LHID for the period from 2009 to 2013. This study enrolled patients who received a diagnosis of blepharitis according to the International Classification of Diseases, Ninth Revision, diagnostic code. The exclusion criteria were legal blindness, eyeball removal, ocular tumours prior to the diagnosis of blepharitis, and patients diagnosed with blepharitis and initiated antibiotic treatment concurrently. An age-matched, gender-matched and disease-matched population without blepharitis served as the control group. Multivariate analysis with a multiple Cox regression model was applied to analyse the data.
   Results In this study, a total of 10 093 patients with blepharitis were included in the study group, and another 40 372 participants without blepharitis were included in the control group. Conditional logistic regression revealed a higher cumulative probability of hyperlipidaemia and coronary arterial disease. After adjustment, patients with blepharitis had a higher probability of developing new MetS than controls. According to subgroup analysis, hyperlipidaemia and coronary artery diseases were significantly correlated with the prior development of blepharitis. However, hypertension and diabetes mellitus and insulin resistance showed no correlation with blepharitis.
   Conclusion Blepharitis is significantly related to MetS and can serve as an early sign of MetS. Additional studies should examine the relationship between blepharitis and MetS in terms of severity.
C1 [Lee, Chia-Yi; Chao, Shih-Chun; Lin, Hung-Yu] Show Chwan Mem Hosp, Dept Ophthalmol, Changhua, Taiwan.
   [Lin, Hung-Yu; Yang, Shun-Fa] Chung Shan Med Univ, Inst Med, Taichung 40201, Taiwan.
   [Chen, Hung-Chi] Chang Gung Mem Hosp, Dept Ophthalmol, Taoyuan, Taiwan.
   [Chen, Hung-Chi] Chang Gung Univ, Dept Med, Coll Med, Taoyuan, Taiwan.
   [Chen, Hung-Chi] Chang Gung Mem Hosp, Ctr Tissue Engn, Linkou, Taiwan.
   [Lin, Hui-Wen] Asia Univ, Dept Optometry, Taichung, Taiwan.
   [Lin, Hui-Wen] China Med Univ, Dept Med Res, China Med Univ Hosp, Taichung, Taiwan.
   [Huang, Jing-Yang; Yang, Shun-Fa] Chung Shan Med Univ Hosp, Dept Med Res, Taichung, Taiwan.
   [Chao, Shih-Chun] Natl Chiao Tung Univ, Dept Elect & Comp Engn, Hsinchu, Taiwan.
   [Chao, Shih-Chun] Cent Taiwan Univ Sci & Technol, Dept Optometry, Taichung, Taiwan.
   [Yeh, Chao-Bin] Chung Shan Med Univ, Sch Med, Dept Emergency Med, Taichung, Taiwan.
   [Yeh, Chao-Bin] Chung Shan Med Univ Hosp, Dept Emergency Med, Taichung, Taiwan.
   [Lin, Hung-Yu] Chung Shan Med Univ, Dept Optometry, Taichung, Taiwan.
   [Lin, Hung-Yu] Yuanpei Univ Med Technol, Dept Optometry, Hsinchu, Taiwan.
C3 Show Chwan Memorial Hospital; Chung Shan Medical University; Chang Gung
   Memorial Hospital; Chang Gung University; Chang Gung Memorial Hospital;
   Asia University Taiwan; China Medical University Taiwan; China Medical
   University Hospital - Taiwan; Chung Shan Medical University; Chung Shan
   Medical University Hospital; National Yang Ming Chiao Tung University;
   Central Taiwan University Science & Technology; Chung Shan Medical
   University; Chung Shan Medical University; Chung Shan Medical University
   Hospital; Chung Shan Medical University
RP Lin, HY (corresponding author), Show Chwan Mem Hosp, Dept Ophthalmol, Changhua, Taiwan.; Lin, HY; Yang, SF (corresponding author), Chung Shan Med Univ, Inst Med, Taichung 40201, Taiwan.
EM anthonyhungyulin@hotmail.com; ysf@csmu.edu.tw
RI Yang, Shun-Fa/AAN-1519-2020; Kuo, Shu-Chen/U-6115-2019
OI Chen, Hung-Chi/0000-0002-1117-7878
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NR 25
TC 9
Z9 9
U1 2
U2 5
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 0007-1161
EI 1468-2079
J9 BRIT J OPHTHALMOL
JI Br. J. Ophthalmol.
PD SEP
PY 2018
VL 102
IS 9
BP 1283
EP 1287
DI 10.1136/bjophthalmol-2017-310975
PG 5
WC Ophthalmology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Ophthalmology
GA GU2ON
UT WOS:000445109700019
PM 29146760
DA 2025-06-11
ER

PT J
AU Kaikkonen, JE
   Mikkilä, V
   Magnussen, CG
   Juonala, M
   Viikari, JSA
   Raitakari, OT
AF Kaikkonen, Jari E.
   Mikkila, Vera
   Magnussen, Costan G.
   Juonala, Markus
   Viikari, Jorma S. A.
   Raitakari, Olli T.
TI Does childhood nutrition influence adult cardiovascular disease
   risk?-Insights from the Young Finns Study
SO ANNALS OF MEDICINE
LA English
DT Article
DE Adulthood; cardiovascular disease; childhood nutrition; food intake;
   intima media thickness; metabolic syndrome; vascular health
ID BODY-MASS INDEX; CORONARY-HEART-DISEASE; INTIMA-MEDIA THICKNESS; TYPE-2
   DIABETES-MELLITUS; MAJOR DIETARY PATTERNS; POSTMENOPAUSAL WOMEN;
   ARTERIAL STIFFNESS; METABOLIC SYNDROME; PHYSICAL-ACTIVITY; OXIDATIVE
   STRESS
AB There is a paucity of detailed information about the role of childhood food patterns or on the impact of individual nutrients on adulthood cardiovascular disease (CVD). We review here the reports that have investigated these questions in the Young Finns Study with its 3596 subjects at baseline, aged 3 to 18 years. All the participants filled in a food habit questionnaire, and half of them provided a 48-hour dietary recall interview. In adulthood, cardiovascular risk factors as well as structural and functional markers of subclinical atherosclerosis were measured, i.e. carotid artery intima media thickness (IMT), and measurements of arterial elasticity and brachial artery endothelial function. Our data demonstrate that dietary patterns can already be identified in childhood. These patterns remain relatively stable over the life-course and associate with cardiovascular risk factors and vascular markers of subclinical atherosclerosis. For example, a traditional dietary pattern characterized by low intakes of fruits and vegetables was associated with elevated increased adulthood IMT especially in men, whereas a diet with a high intake of vegetables was independently associated with increased arterial elasticity in both genders. Our findings and the current literature suggest that childhood nutrition has a significant role in the progression of CVD.
C1 [Kaikkonen, Jari E.; Magnussen, Costan G.; Juonala, Markus; Raitakari, Olli T.] Univ Turku, Res Ctr Appl & Prevent Cardiovasc Med, FIN-20520 Turku, Finland.
   [Mikkila, Vera] Univ Helsinki, Dept Food & Environm Sci, Div Nutr, Helsinki, Finland.
   [Magnussen, Costan G.] Univ Tasmania, Menzies Res Inst Tasmania, Hobart, Tas, Australia.
   [Viikari, Jorma S. A.] Univ Turku, Dept Med, FIN-20520 Turku, Finland.
   [Juonala, Markus; Viikari, Jorma S. A.] Turku Univ Hosp, FIN-20520 Turku, Finland.
   [Raitakari, Olli T.] Turku Univ Hosp, Dept Clin Physiol, FIN-20520 Turku, Finland.
C3 University of Turku; University of Helsinki; University of Tasmania;
   University of Turku; University of Turku; University of Turku
RP Kaikkonen, JE (corresponding author), Univ Turku, Res Ctr Appl & Prevent Cardiovasc Med, Kiinamyllynkatu 10, FIN-20520 Turku, Finland.
EM jari.kaikkonen@utu.fi
RI Magnussen, Costan/AAA-8260-2020; Raitakari, Olli/AAQ-7389-2021;
   Magnussen, Costan/J-7177-2014
OI Juonala, Markus/0000-0001-9498-364X; Magnussen,
   Costan/0000-0002-6238-5730
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NR 64
TC 120
Z9 126
U1 0
U2 46
PU INFORMA HEALTHCARE
PI NEW YORK
PA 52 VANDERBILT AVE, NEW YORK, NY 10017 USA
SN 0785-3890
J9 ANN MED
JI Ann. Med.
PD MAR
PY 2013
VL 45
IS 2
BP 120
EP 128
DI 10.3109/07853890.2012.671537
PG 9
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 084GX
UT WOS:000314527800004
PM 22494087
OA Bronze
DA 2025-06-11
ER

PT J
AU Hayden, MR
   Tyagi, SC
AF Hayden, Melvin R.
   Tyagi, Suresh C.
TI Vasa vasorum in plaque angiogenesis, metabolic syndrome, type 2 diabetes
   mellitus, and atheroscleropathy: a malignant transformation
SO CARDIOVASCULAR DIABETOLOGY
LA English
DT Review
AB Background: Vascularization is an exciting and complex mechanism involving angiogenesis and arteriogenesis. The metabolic syndrome (MS) and type 2 diabetes mellitus (T2DM) are associated with multiple metabolic toxicities, which result in reactive oxygen species (ROS) due to an elevated tension of oxidative-redox stress and an accelerated atherosclerosis termed atheroscleropathy.
   Results: This atheroscleropathy is associated with accelerated angiogenesis within the vulnerable, thin-cap fibro-atheroma, prone to rupture resulting in acute coronary syndromes (ACS). The resulting intimopathy with its neovascularization due to angiogenesis of the adventitial vasa vasorum (Vv) is prone to intraplaque hemorrhage (IPH). These IPH are associated with destabilization of the vulnerable plaques resulting in plaque erosion and plaque rupture resulting in ACS. In atheroscleropathy the adventitial Vv invades the plaque in a malignant-like fashion and concurrently is associated with chronic inflammation, as macrophages are being deposited within the shoulder regions of these vulnerable plaques. These angiogenic Vv provide a custom delivery vascular network for multiple detrimental substrates, which further accelerates the growth of these vulnerable plaques and atheroscleropathy. There exists a vascularization paradox in MS and T2DM, in that, angiogenesis within the plaque is induced and arteriogenesis is impaired.
   Conclusion: This review will attempt to provide a database of knowledge regarding the vascularization process (angiogenesis and arteriogenesis) and its mechanisms to better understand the increased cardiovascular risk and the increased morbidity and mortality associated with MS and T2DM.
C1 [Hayden, Melvin R.] Univ Missouri Columbia, Dept Family & Community Med, Camdenton, MO 65020 USA.
   [Tyagi, Suresh C.] Univ Louisville, Sch Med, Dept Physiol & Biophys, Louisville, KY 40292 USA.
C3 University of Missouri System; University of Missouri Columbia;
   University of Louisville
RP Hayden, MR (corresponding author), Univ Missouri Columbia, Dept Family & Community Med, POB 1140,Lk Rd 5-87, Camdenton, MO 65020 USA.
EM mrh29@usmo.com; s0tyag01@louisville.edu
RI Stefanadis, Christodoulos/ABH-2232-2020
OI Stefanadis, Christodoulos/0000-0001-5974-6454
FU NIH [HL-71010, HL-74185]
FX A part of this study was supported by NIH grants HL-71010 and HL-74185.
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NR 48
TC 105
Z9 119
U1 0
U2 6
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1475-2840
J9 CARDIOVASC DIABETOL
JI Cardiovasc. Diabetol.
PY 2004
VL 3
AR 1
DI 10.1186/1475-2840-3-1
PG 16
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism
GA V23DC
UT WOS:000208322500001
PM 14761253
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Federico, M
   De la Fuente, S
   Palomeque, J
   Sheu, SS
AF Federico, Marilen
   De la Fuente, Sergio
   Palomeque, Julieta
   Sheu, Shey-Shing
TI The role of mitochondria in metabolic disease: a special emphasis on
   heart dysfunction
SO JOURNAL OF PHYSIOLOGY-LONDON
LA English
DT Review
DE diabetic cardiomyopathy; heart; metabolic diseases; mitochondria;
   oxidative stress
ID HIGH-FAT DIET; PERMEABILITY TRANSITION; CARDIAC MITOCHONDRIA; RYANODINE
   RECEPTOR; OXIDATIVE-PHOSPHORYLATION; DIABETIC CARDIOMYOPATHY; DIASTOLIC
   DYSFUNCTION; SIGNALING PATHWAYS; CALCIUM UNIPORTER; ATP SYNTHASE
AB Metabolic diseases (MetDs) embrace a series of pathologies characterized by abnormal body glucose usage. The known diseases included in this group are metabolic syndrome, prediabetes and diabetes mellitus types 1 and 2. All of them are chronic pathologies that present metabolic disturbances and are classified as multi-organ diseases. Cardiomyopathy has been extensively described in diabetic patients without overt macrovascular complications. The heart is severely damaged during the progression of the disease; in fact, diabetic cardiomyopathies are the main cause of death in MetDs. Insulin resistance, hyperglycaemia and increased free fatty acid metabolism promote cardiac damage through mitochondria. These organelles supply most of the energy that the heart needs to beat and to control essential cellular functions, including Ca2+ signalling modulation, reactive oxygen species production and apoptotic cell death regulation. Several aspects of common mitochondrial functions have been described as being altered in diabetic cardiomyopathies, including impaired energy metabolism, compromised mitochondrial dynamics, deficiencies in Ca2+ handling, increases in reactive oxygen species production, and a higher probability of mitochondrial permeability transition pore opening. Therefore, the mitochondrial role in MetD-mediated heart dysfunction has been studied extensively to identify potential therapeutic targets for improving cardiac performance. Herein we review the cardiac pathology in metabolic syndrome, prediabetes and diabetes mellitus, focusing on the role of mitochondrial dysfunctions.
C1 [Federico, Marilen; Palomeque, Julieta] UNLP, Ctr Invest Cardiovasc, Fac Cs Med, CCT La Plata CONICET, La Plata, Argentina.
   [De la Fuente, Sergio; Sheu, Shey-Shing] Thomas Jefferson Univ, Sidney Kimmel Med Coll, Ctr Translat Med, Dept Med, 1020 Locust St,Room 543D, Philadelphia, PA 19107 USA.
   [Palomeque, Julieta] Univ Abierta Interamer, Ctr Altos Estudios Ciencias Humanas & Salud, Caba, Argentina.
C3 Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET);
   National University of La Plata; Thomas Jefferson University
RP Sheu, SS (corresponding author), Thomas Jefferson Univ, Sidney Kimmel Med Coll, Ctr Translat Med, Dept Med, 1020 Locust St,Room 543D, Philadelphia, PA 19107 USA.
EM shey-shing.sheu@jefferson.edu
RI de la fuente, sergio/HMD-7573-2023; Sheu, Shey-Shing/Y-4009-2019
OI De la Fuente, Sergio/0000-0002-8021-2390; Sheu,
   Shey-Shing/0000-0003-3838-3601; Federico, Marilen/0000-0001-9023-6284
FU NIH [R01HL093671, R01HL137266, R01HL142864, R01HL122124]; PS-1 (UAI
   Argentina); PICT [2015-3009]; National Heart Lung and Blood Institute
   [R01HL137266, R01HL142864] Funding Source: NIH RePORTER
FX Thiswork was supported by NIH R01HL093671, R01HL137266, R01HL142864 and
   R01HL122124 (to S.-S.S.); and by PICT 2015-3009 and PS-1 (UAI
   Argentina). M.F. is a doctoral fellow of CONICET.
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NR 166
TC 24
Z9 26
U1 3
U2 23
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-3751
EI 1469-7793
J9 J PHYSIOL-LONDON
JI J. Physiol.-London
PD JUL
PY 2021
VL 599
IS 14
BP 3477
EP 3493
DI 10.1113/JP279376
EA MAY 2021
PG 17
WC Neurosciences; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Physiology
GA TJ1YN
UT WOS:000651410300001
PM 33932959
OA Bronze, Green Accepted
DA 2025-06-11
ER

PT J
AU Xu, MX
   Ge, CX
   Qin, YT
   Gu, TT
   Lv, JX
   Wang, SJ
   Ma, YJ
   Lou, DS
   Li, Q
   Hu, LF
   Nie, XY
   Wang, MX
   Huang, P
   Tan, J
AF Xu, Minxuan
   Ge, Chenxu
   Qin, Yuting
   Gu, Tingting
   Lv, Jinxiao
   Wang, Sujun
   Ma, Yongjie
   Lou, Deshuai
   Li, Qiang
   Hu, Linfeng
   Nie, Xuyuan
   Wang, Mingxing
   Huang, Ping
   Tan, Jun
TI Activated TNF-α/RIPK3 signaling is involved in prolonged high fat
   diet-stimulated hepatic inflammation and lipid accumulation: inhibition
   by dietary fisetin intervention
SO FOOD & FUNCTION
LA English
DT Article
ID LIVER-DISEASE; INSULIN-RESISTANCE; FLAVONOID FISETIN; OXIDATIVE STRESS;
   PROTECTS; MICE; PATHOGENESIS; FIBROSIS; NAFLD; NASH
AB Increasing evidence indicates that high-fat diet (HFD) is a predisposing factor for metabolic syndrome-associated systemic inflammation and nonalcoholic fatty liver disease (NAFLD). Tumor necrosis factor-alpha/receptor-interacting protein kinase 3 (TNF-alpha/RIPK3) axis has recently become regarded as an important regulator and contributor in many inflammation-related diseases. Fisetin (Fn) is a bioactive flavonoid polyphenol with anti-inflammatory and anti-tumor activity. Lately it has gained increasing attention due to its potential advantages in prevention of tumors, metabolic disorders, neuroinflammation and chronic liver injury. However, its role in NAFLD is still not fully understood. Thus, we studied whether prolonged HFD causes TNF-alpha/RIPK3 activation-associated hepatic steatosis, further evaluating the protective effects of Fn in HFD-fed mice. As expected, HFD promotes metabolic syndrome and pro-inflammatory cytokine generation in serum, enhances liver inflammatory infiltration-related lipid accumulation by increase of TNF-alpha/RIPK3 activation, ultimately resulting in development of nonalcoholic steatohepatitis. In contrast to this, dietary Fn intervention could suppress metabolic disorder and HFD-triggered hepatic function loss, downregulate TNF-alpha/RIPK3 signaling-associated hepatic inflammation, balance lipid metabolism-related gene expression, and finally inhibit lipid accumulation and steatohepatitis. Hence, Fn restrains HFD-induced hepatic inflammation and lipid deposition by downregulating metabolic disorder and excessive liver inflammation-associated TNF-alpha/RIPK3 axis activation.
C1 [Xu, Minxuan; Ge, Chenxu; Lou, Deshuai; Li, Qiang; Hu, Linfeng; Nie, Xuyuan; Tan, Jun] Chongqing Univ Educ, Sch Biol & Chem Engn, Chongqing Key Lab Med Resources Three Gorges Rese, Chongqing 400067, Peoples R China.
   [Xu, Minxuan; Ge, Chenxu; Lou, Deshuai; Li, Qiang; Hu, Linfeng; Nie, Xuyuan; Tan, Jun] Chongqing Univ Educ, Res Ctr Brain Intellectual Promot & Dev Children, Chongqing 400067, Peoples R China.
   [Qin, Yuting; Lv, Jinxiao] Ocean Univ China, Sch Med & Pharm, Qingdao 266100, Shandong, Peoples R China.
   [Gu, Tingting] Nanjing Univ, Coll Engn & Appl Sci, Nanjing 210023, Jiangsu, Peoples R China.
   [Wang, Sujun; Ma, Yongjie; Wang, Mingxing] Luoyang Normal Univ, Coll Food & Drug, Luoyang 471934, Peoples R China.
   [Huang, Ping] Chongqing Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Chongqing 400000, Peoples R China.
C3 Chongqing University of Education; Chongqing University of Education;
   Ocean University of China; Nanjing University; Luoyang Normal
   University; Chongqing Medical University
RP Hu, LF; Tan, J (corresponding author), Chongqing Univ Educ, Sch Biol & Chem Engn, Chongqing Key Lab Med Resources Three Gorges Rese, Chongqing 400067, Peoples R China.; Hu, LF; Tan, J (corresponding author), Chongqing Univ Educ, Res Ctr Brain Intellectual Promot & Dev Children, Chongqing 400067, Peoples R China.
EM afeng1224@hotmail.com; tanjunmail@126.com
RI hu, linfeng/C-6491-2014
OI Xu, Minxuan/0000-0002-0742-4717
FU National Natural Science Foundation of China (NSFC) [81703527];
   Chongqing Research Program of Basic Research and Frontier Technology
   [cstc2017jcyjAX0356, cstc2018jcyjA3686, cstc2018jcyjA1472,
   cstc2018jcyjA3533]; 2018 Chongqing College Students' Innovation and
   Entrepreneurship Training Project [201814388021, 201814388022];
   School-level Research Program of Chongqing University of Education
   [KY201710B, 17GZKP01]; Advanced Programs of Post-doctor of Chongqing
   [2017LY39]
FX This work was supported by National Natural Science Foundation of China
   (NSFC grant number: 81703527); Chongqing Research Program of Basic
   Research and Frontier Technology (grant number: cstc2017jcyjAX0356,
   cstc2018jcyjA3686, cstc2018jcyjA1472 and cstc2018jcyjA3533); 2018
   Chongqing College Students' Innovation and Entrepreneurship Training
   Project (grant number: 201814388021 and 201814388022); School-level
   Research Program of Chongqing University of Education (grant number:
   KY201710B and 17GZKP01) and Advanced Programs of Post-doctor of
   Chongqing (grant number: 2017LY39).
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NR 39
TC 38
Z9 41
U1 0
U2 34
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PD MAR
PY 2019
VL 10
IS 3
BP 1302
EP 1316
DI 10.1039/c8fo01615a
PG 15
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA HS4AY
UT WOS:000463805200046
PM 30793717
DA 2025-06-11
ER

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AU Stabile, AM
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   Pistilli, A
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   Rende, Mario
   Trama, Francesco
   Bartolini, Desiree
   Zucchi, Alessandro
   Costantini, Elisabetta
TI The Role of NGF and Its Receptor TrKA in Patients With Erectile
   Dysfunction
SO FRONTIERS IN UROLOGY
LA English
DT Article
DE erectile dysfunction; metabolic syndrome; NGF; TrKA; thiols
ID NERVE GROWTH-FACTOR; OXIDATIVE STRESS; HOMEOSTASIS; EXPRESSION;
   NEUROPATHY; YOUNG
AB The aim of our study was to investigate the plasma NGF concentration and TrkA/p75NTR receptor expression on white blood cells (WBCs), in peripheral and corpus cavernosum blood isolated from patients with erectile dysfunction and metabolic syndrome (ED/MetS). This was a pilot case-control study. Inclusion criteria were as follows: men 18-65 years with ED and MetS and healthy subjects. The first sampling was performed at the level of the cubital vein (VC). Subsequently, 20 mu g of intracavernous alprostadil was administered, and a second blood draw from the corpora cavernosa (CC) was performed once erection was achieved. Subsequently, the third blood sample was repeated at the level of the VC. We enrolled 8 cases with ED/MetS and 8 controls. There was no significant difference between the case and control group in terms of mean age (49.3 +/- 5.9 and 53.13 +/- 8.9, respectively). The case group had a lower IIEF score compared to the control group (14 +/- 3.2 versus 27.3 +/- 2.1; p < 0.05). Decreased NGF and TrKA expression on WBC and thiols were found in the plasma of ED/MetS patients compared to control. The study showed that patients with ED/MetS had a decrease in plasma NGF and thiol concentration, and they had a decrease in TrKA expression on WBCs.
C1 [Stabile, Anna Maria; Pistilli, Alessandra; Rende, Mario; Bartolini, Desiree] Univ Perugia, Sch Med, Dept Med, Sect Human Anat Clin & Forens, Perugia, Italy.
   [Illiano, Ester; Trama, Francesco; Costantini, Elisabetta] Univ Perugia, St Maria Terni Hosp, Androl & Urogynecol Clin, Terni, Italy.
   [Zucchi, Alessandro] Univ Pisa, Dept Translat Res & New Technol, Urol Unit, Pisa, Italy.
C3 University of Perugia; University of Perugia; University of Pisa
RP Trama, F (corresponding author), Univ Perugia, St Maria Terni Hosp, Androl & Urogynecol Clin, Terni, Italy.
EM francescotrama@gmail.com
RI Illiano, Ester/GMX-0540-2022; Bartolini, Desirée/K-5319-2016; Trama,
   Francesco/AAR-2394-2021; Costantini, Elisabetta/K-3875-2018; Zucchi,
   Alessandro/AAI-6797-2020
OI Zucchi, Alessandro/0000-0003-2252-4297
FU Medicine Department, University of Perugia
FX This research was funded by Medicine Department, University of Perugia.
   The funders had no role in the design of the study; in the collection,
   analyses, or interpretation of data; in the writing of the manuscript;
   or in the decision to publish the results.
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NR 32
TC 2
Z9 2
U1 1
U2 1
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 2673-9828
J9 FRONT UROL
JI Front. Urol.
PD MAY 13
PY 2022
VL 2
AR 860612
DI 10.3389/fruro.2022.860612
PG 7
WC Urology & Nephrology
WE Emerging Sources Citation Index (ESCI)
SC Urology & Nephrology
GA N4D0Q
UT WOS:001363851800001
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Yuan, QH
   Xie, F
   Huang, W
   Hu, M
   Yan, QL
   Chen, ZM
   Zheng, Y
   Liu, L
AF Yuan, Qianghua
   Xie, Fan
   Huang, Wei
   Hu, Mei
   Yan, Qilu
   Chen, Zemou
   Zheng, Yan
   Liu, Li
TI The review of alpha-linolenic acid: Sources, metabolism, and
   pharmacology
SO PHYTOTHERAPY RESEARCH
LA English
DT Review
DE dietary sources; metabolism; pharmacology; toxicology; alpha-linolenic
   acid
ID POLYUNSATURATED FATTY-ACIDS; NF-KAPPA-B; FLAXSEED OIL SUPPLEMENTATION;
   CARDIOVASCULAR RISK-FACTORS; MODULATE LIPID-METABOLISM; INDUCED
   OXIDATIVE STRESS; BREAST-CANCER CELLS; DOUBLE-BLIND; INSULIN-RESISTANCE;
   N-3 LCPUFA
AB alpha-linolenic acid (ALA, 18:3n-3) is a carboxylic acid composed of 18 carbon atoms and three cis double bonds, and is an essential fatty acid indispensable to the human body. This study aims to systematically review related studies on the dietary sources, metabolism, and pharmacological effects of ALA. Information on ALA was collected from the internet database PubMed, Elsevier, ResearchGate, Web of Science, Wiley Online Library, and Europe PMC using a combination of keywords including "pharmacology," "metabolism," "sources." The following findings are mainly contained. (a) ALA can only be ingested from food and then converted into eicosapentaenoic acid and docosahexaenoic acid in the body. (b) This conversion process is relatively limited and affected by many factors such as dose, gender, and disease. (c) Pharmacological research shows that ALA has the anti-metabolic syndrome, anticancer, antiinflammatory, anti-oxidant, anti-obesity, neuroprotection, and regulation of the intestinal flora properties. (d) There are the most studies that prove ALA has anti-metabolic syndrome effects, including experimental studies and clinical trials. (e) The therapeutic effect of ALA will be affected by the dosage. In short, ALA is expected to treat many diseases, but further high quality studies are needed to firmly establish the clinical efficacy of ALA.
C1 [Yuan, Qianghua; Xie, Fan; Hu, Mei; Zheng, Yan; Liu, Li] Hosp Chengdu Univ Tradit Chinese Med, Chengdu 610041, Sichuan, Peoples R China.
   [Huang, Wei; Yan, Qilu; Chen, Zemou] Hanyuan Hosp Tradit Chinese Med, Yaan, Peoples R China.
C3 Chengdu University of Traditional Chinese Medicine
RP Yuan, QH (corresponding author), Hosp Chengdu Univ Tradit Chinese Med, Chengdu 610041, Sichuan, Peoples R China.
EM yuanqianghuahtcm@163.com
RI 袁, 强华/GSM-9788-2022
FU Sichuan Provincial Administration of Traditional Chinese Medicine
   [2018HJZX018]
FX This work was supported by the Sichuan Provincial Administration of
   Traditional Chinese Medicine (2018HJZX018).
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NR 214
TC 133
Z9 143
U1 22
U2 135
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0951-418X
EI 1099-1573
J9 PHYTOTHER RES
JI Phytother. Res.
PD JAN
PY 2022
VL 36
IS 1
BP 164
EP 188
DI 10.1002/ptr.7295
EA SEP 2021
PG 25
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA YJ6VJ
UT WOS:000700038000001
PM 34553434
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Amiot, MJ
   Riva, C
   Vinet, A
AF Amiot, M. J.
   Riva, C.
   Vinet, A.
TI Effects of dietary polyphenols on metabolic syndrome features in humans:
   a systematic review
SO OBESITY REVIEWS
LA English
DT Review
DE Blood pressure; dyslipidemia; insulin resistance; weight management
ID GREEN TEA SUPPLEMENTATION; BLOOD-PRESSURE; GUT MICROBIOTA;
   CARDIOVASCULAR RISK; NITRIC-OXIDE; TERM SUPPLEMENTATION;
   CATECHIN-POLYPHENOLS; ENDOTHELIAL FUNCTION; INSULIN SENSITIVITY;
   ENERGY-EXPENDITURE
AB Dietary polyphenols constitute a large family of bioactive substances potential beneficial effect on metabolic syndrome (MetS). This review summarizes the results of clinical studies on patients with MetS involving the chronic supplementation of a polyphenol-rich diet, foods, extracts or with single phenolics on the features of MetS (obesity, dyslipidemia, blood pressure and glycaemia) and associated complications (oxidative stress and inflammation). Polyphenols were shown to be efficient, especially at higher doses, and there were no specific foods or extracts able to alleviate all the features of MetS. Green tea, however, significantly reduced body mass index and waist circumference and improved lipid metabolism. Cocoa supplementation reduced blood pressure and blood glucose. Soy isoflavones, citrus products, hesperidin and quercetin improved lipid metabolism, whereas cinnamon reduced blood glucose. In numerous clinical studies, antioxidative and anti-inflammatory effects were not significant after polyphenol supplementation in patients with MetS. However, some trials pointed towards an improvement of endothelial function in patients supplemented with cocoa, anthocyanin-rich berries, hesperidin or resveratrol. Therefore, diets rich in polyphenols, such as the Mediterranean diet, which promote the consumption of diverse polyphenol-rich products could be an effective nutritional strategy to improve the health of patients with MetS. (c) 2016 The Authors. Obesity Reviews published by John Wiley & Sons Ltd on behalf of World Obesity
C1 [Amiot, M. J.] INRA, Unite Mixte Rech UMR Nutr Obes & Risk Thrombosis, Paris, France.
   [Amiot, M. J.] INSERM, Paris, France.
   [Amiot, M. J.] Aix Marseille Univ, Marseille, France.
   [Riva, C.; Vinet, A.] Univ Avignon, LaPEC, EA4278, Avignon, France.
C3 INRAE; Institut National de la Sante et de la Recherche Medicale
   (Inserm); Aix-Marseille Universite; Avignon Universite
RP Amiot, MJ (corresponding author), Aix Marseille Univ, INSERM 1260, UMR 1062, INRA,UMR NORT Nutr Obesite & Risque Thrombot,Fac, 27 Blvd Jean Moulin, F-13385 Marseille 05, France.
EM marie-josephe.amiot-carlin@univ-amu.fr
RI AMIOT, MARIE/N-8894-2019; AMIOT, Marie Josephe/M-1203-2017
OI AMIOT, Marie Josephe/0000-0003-4563-4587
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NR 90
TC 317
Z9 347
U1 8
U2 319
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1467-7881
EI 1467-789X
J9 OBES REV
JI Obes. Rev.
PD JUL
PY 2016
VL 17
IS 7
BP 573
EP 586
DI 10.1111/obr.12409
PG 14
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA DP5LE
UT WOS:000378537600002
PM 27079631
OA hybrid, Green Published
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Iyer, A
   Brown, L
AF Iyer, Abishek
   Brown, Lindsay
TI Fermented Wheat Germ Extract (Avemar) in the Treatment of Cardiac
   Remodeling and Metabolic Symptoms in Rats
SO EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Article
ID OXIDATIVE STRESS; ANTIOXIDANT STATUS; MEDICAL NUTRIMENT; COENZYME Q(10);
   INHIBITION; PREVENTION; INSULIN; GLUCOSE; HYPERTENSION; HYPERTROPHY
AB Avemar, a product of industrial fermentation of wheat germ with a standardized content of benzoquinone and plant flavonoids, has been tested as an anti-cancer and immunomodulatory dietary supplement. Proposed mechanisms include anti-oxidant and anti-inflammatory actions. This study has determined whether these actions of Avemar may also be useful in the treatment of cardiovascular diseases. Two experimental rat models of cardiovascular remodeling were used in this project: the deoxycorticosterone acetate (DOCA)-salt-induced model of chronic hypertension (study I) and a high-carbohydrate/high-fat diet-induced model producing chronic symptoms of the metabolic syndrome and its associated cardiovascular complications (study II). Our results in these rat models of hypertension and diet-induced obesity show that treatment with Avemar improved cardiac function, decreased macrophage infiltration resulting in decreased collagen deposition in the ventricular myocardium, reversed an increased stiffness of the left ventricle in the diseased hearts and attenuated increased plasma malondialdehyde concentrations. In addition to the changes in the heart, Avemar reversed glucose intolerance, normalized systolic blood pressure and decreased visceral fat deposition in rats fed a high-fat/high-carbohydrate diet. In conclusion, the fermented wheat germ extract Avemar has a potential role in attenuating chronic hypertension, diabetes or metabolic syndrome-induced cardiovascular symptoms along with metabolic abnormalities such as glucose tolerance and obesity.
C1 [Iyer, Abishek; Brown, Lindsay] Univ Queensland, Sch Biomed Sci, Brisbane, Qld 4072, Australia.
C3 University of Queensland
RP Brown, L (corresponding author), Univ Queensland, Sch Biomed Sci, Brisbane, Qld 4072, Australia.
EM l.brown@uq.edu.au
RI Iyer, Abishek/C-9767-2017
OI Iyer, Abishek/0000-0001-9533-5265
FU University of Queensland; Medimpex Pty Ltd, Mudgeeraba, Australia
FX The University of Queensland; Medimpex Pty Ltd, Mudgeeraba, Australia.
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NR 47
TC 28
Z9 29
U1 0
U2 17
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1741-427X
EI 1741-4288
J9 EVID-BASED COMPL ALT
JI Evid.-based Complement Altern. Med.
PY 2011
VL 2011
BP 1
EP 10
DI 10.1093/ecam/nep090
PG 10
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA 801UJ
UT WOS:000293465800001
PM 19622599
OA Green Submitted, Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Stewart, BJ
   Roede, JR
   Doorn, JA
   Petersen, DR
AF Stewart, Benjamin J.
   Roede, James R.
   Doorn, Jonathan A.
   Petersen, Dennis R.
TI Lipid aldehyde-mediated cross-linking of apolipoprotein B-100 inhibits
   secretion from HepG2 cells
SO BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
LA English
DT Article
DE 4-hydroxynonenal; 4-oxononenal; Apolipoprotein B-100; Microtubules;
   Lipid peroxidation
ID LOW-DENSITY-LIPOPROTEIN; TRIGLYCERIDE TRANSFER PROTEIN; METABOLIC
   SYNDROME; MICROSOMAL TRIGLYCERIDE; ISOLATED HEPATOCYTES; HEPATIC
   STEATOSIS; PEROXIDATION; PRODUCT; MICROTUBULES; OXIDATION
AB Hepatic oxidative stress and lipid peroxidation are common features of several prevalent disease states. including alcoholic liver disease (ALD) and non-alcoholic fatty liver disease (NAFLD), a common component of the metabolic syndrome. These conditions are characterized in part by excessive accumulation of lipids within hepatocytes, which can lead to autocatalytic degradation of cellular lipids giving rise to electrophilic end products of lipid peroxidation. The pathobiology of reactive lipid aldehydes remains poorly understood. We therefore sought to investigate the effects of 4-hydroxynonenal (4-HNE) and 4-oxononenal (4-ONE) on the transport and secretion of very low-density lipoprotein using HepG2 cells as a model hepatocyte system. Physiologically relevant concentrations of 4-HNE and 4-ONE rapidly disrupted cellular microtubules in a concentration-dependent manner. Interestingly, 4-ONE reduced apolipoprotein B-100 (ApoB) secretion while 4-HNE did not significantly impair secretion. Both 4-HNE and 4-ONE formed adducts with ApoB protein, but 4-HNE adducts were detectable as mono-adducts, while 4-ONE adducts were present as protein-protein cross-links. These results demonstrate that reactive aldehydes generated by lipid peroxidation can differ in their biological effects, and that these differences can be mechanistically explained by the structures of the protein adducts; formed. Published by Elsevier B.V.
C1 [Stewart, Benjamin J.; Roede, James R.; Petersen, Dennis R.] Univ Colorado Denver, Dept Pharmaceut Sci, Sch Pharm, Aurora, CO 80045 USA.
   [Doorn, Jonathan A.] Univ Iowa, Div Med & Nat Prod Chem, Coll Pharm, Iowa City, IA 52242 USA.
C3 University of Colorado System; University of Colorado Anschutz Medical
   Campus; Children's Hospital Colorado; University of Iowa
RP Stewart, BJ (corresponding author), Sch Pharm C238, Res Bldg 2,12700 19th Ave,POB 6511, Aurora, CO 80045 USA.
EM Benjamin.Stewart@ucdenver.edu
OI Doorn, Jonathan/0000-0001-9646-9871
FU NIH [1 F31 AA015821-01, R37 AA 09300]
FX This work was supported by NIH 1 F31 AA015821-01 and NIH R37 AA 09300.
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NR 54
TC 19
Z9 20
U1 0
U2 6
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1388-1981
EI 1879-2618
J9 BBA-MOL CELL BIOL L
JI Biochim. Biophys. Acta Mol. Cell Biol. Lipids
PD AUG
PY 2009
VL 1791
IS 8
BP 772
EP 780
DI 10.1016/j.bbalip.2009.04.004
PG 9
WC Biochemistry & Molecular Biology; Biophysics; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Cell Biology
GA 479HQ
UT WOS:000268650700010
PM 19393338
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Perks, KL
   Ferreira, N
   Ermer, JA
   Rudler, DL
   Richman, TR
   Rossetti, G
   Matthews, VB
   Ward, NC
   Rackham, O
   Filipovska, A
AF Perks, Kara L.
   Ferreira, Nicola
   Ermer, Judith A.
   Rudler, Danielle L.
   Richman, Tara R.
   Rossetti, Giulia
   Matthews, Vance B.
   Ward, Natalie C.
   Rackham, Oliver
   Filipovska, Aleksandra
TI Reduced mitochondrial translation prevents diet-induced metabolic
   dysfunction but not inflammation
SO AGING-US
LA English
DT Article
DE mitochondria; stress response; mTOR and insulin signaling pathways;
   obesity; metabolic syndrome
ID TRANSCRIPTION FACTOR; INSULIN-RESISTANCE; GUT MICROBIOTA; OBESITY;
   STRESS; PHOSPHORYLATION; OXIDATION; MTOR; ACTIVATION; CAPACITY
AB The contribution of dysregulated mitochondrial gene expression and consequent imbalance in biogenesis is not well understood in metabolic disorders such as insulin resistance and obesity. The ribosomal RNA maturation protein PTCD1 is essential for mitochondrial protein synthesis and its reduction causes adult-onset obesity and liver steatosis. We used haploinsufficient Ptcd1 mice fed normal or high fat diets to understand how changes in mitochondrial biogenesis can lead to metabolic dysfunction. We show that Akt-stimulated reduction in lipid content and upregulation of mitochondrial biogenesis effectively protected mice with reduced mitochondrial protein synthesis from excessive weight gain on a high fat diet, resulting in improved glucose and insulin tolerance and reduced lipid accumulation in the liver. However, inflammation of the white adipose tissue and early signs of fibrosis in skeletal muscle, as a consequence of reduced protein synthesis, were exacerbated with the high fat diet. We identify that reduced mitochondrial protein synthesis and OXPHOS biogenesis can be recovered in a tissue-specific manner via Akt-mediated increase in insulin sensitivity and transcriptional activation of the mitochondrial stress response.
C1 [Perks, Kara L.; Ferreira, Nicola; Ermer, Judith A.; Rudler, Danielle L.; Richman, Tara R.; Rossetti, Giulia; Rackham, Oliver; Filipovska, Aleksandra] Univ Western Australia, QEII Med Ctr, Med Res Ctr, Harry Perkins Inst Med Res, Nedlands, WA, Australia.
   [Perks, Kara L.; Rackham, Oliver] Curtin Univ, Sch Pharm & Biomed Sci, Bentley, WA, Australia.
   [Matthews, Vance B.] Univ Western Australia, Sch Biomed Sci, Perth, WA, Australia.
   [Ward, Natalie C.] Univ Western Australia, Sch Med, Royal Perth Hosp Unit, Perth, WA, Australia.
   [Ward, Natalie C.] Curtin Univ, Sch Publ Hlth, Perth, WA, Australia.
   [Ward, Natalie C.] Curtin Univ, Curtin Hlth Innovat Res Inst, Perth, WA, Australia.
   [Rackham, Oliver] Curtin Univ, Curtin Hlth Innovat Res Inst, Bentley, WA, Australia.
   [Filipovska, Aleksandra] Univ Western Australia, Sch Mol Sci, Crawley, WA, Australia.
C3 Harry Perkins Institute of Medical Research; Queen Elizabeth II Medical
   Centre; University of Western Australia; Curtin University; University
   of Western Australia; University of Western Australia; East Metropolitan
   Health Service; Royal Perth Hospital; Curtin University; Curtin
   University; Curtin University; University of Western Australia
RP Filipovska, A (corresponding author), Univ Western Australia, QEII Med Ctr, Med Res Ctr, Harry Perkins Inst Med Res, Nedlands, WA, Australia.
EM aleksandra.filipovska@uwa.edu.au
RI Rossetti, Giulia/U-2448-2019; Rackham, Oliver/AGO-0005-2022; Perks,
   Kara/O-8701-2014; Rackham, Oliver/E-1264-2013
OI Ermer, Judith Anna/0000-0003-0234-9620; Filipovska,
   Aleksandra/0000-0002-6998-8403; Rudler, Danielle/0000-0002-5540-6548;
   Richman, Tara/0000-0002-0610-6047; Rackham, Oliver/0000-0002-5301-9624;
   Ward, Natalie/0000-0002-6042-437X
FU National Health and Medical Research Council [APP1159594, APP1154932,
   APP1154646]; Australian Research Council; Cancer Council of Western
   Australia; Dora Lush NHMRC scholarship; UWA Postgraduate Scholarship;
   AMDF top-up scholarship; UWA Postgraduate Scholarships; CSIRO
   Fellowship; Bright Spark Foundation; Raine Foundation
FX This project was supported by fellowships and project grants from the
   National Health and Medical Research Council (APP1159594, APP1154932,
   APP1154646 to AF and OR), Australian Research Council (to AF and OR),
   the Cancer Council of Western Australia (to OR and AF). KP was supported
   by a Dora Lush NHMRC scholarship, UWA Postgraduate Scholarship and AMDF
   top-up scholarship. GR, NF, and DR are all supported by UWA Postgraduate
   Scholarships. TR is support by CSIRO Fellowship and the Bright Spark and
   Raine Foundations.
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NR 65
TC 6
Z9 6
U1 1
U2 6
PU IMPACT JOURNALS LLC
PI ORCHARD PARK
PA 6666 E QUAKER ST, STE 1, ORCHARD PARK, NY 14127 USA
SN 1945-4589
J9 AGING-US
JI Aging-US
PD OCT 15
PY 2020
VL 12
IS 19
BP 19677
EP 19700
DI 10.18632/aging.104010
PG 24
WC Cell Biology; Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Geriatrics & Gerontology
GA OF3EF
UT WOS:000581094800058
PM 33024056
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Moreno, MU
   Zalba, G
AF Moreno, Maria U.
   Zalba, Guillermo
TI CYBA GENE VARIANTS AS BIOMARKERS FOR CORONARY ARTERY DISEASE
SO DRUG NEWS & PERSPECTIVES
LA English
DT Article
ID P22 PHOX GENE; NADPH OXIDASE P22PHOX; CHRONIC GRANULOMATOUS-DISEASE;
   NEUTROPHIL CYTOCHROME-B; BINDING PROTEIN-DELTA; OXIDATIVE-STRESS;
   NAD(P)H OXIDASE; C242T POLYMORPHISM; NOX FAMILY; CARDIOVASCULAR-DISEASE
AB Oxidative stress plays a key rote in the pathophysiology of coronary artery disease, and constitutes a common mechanism behind the risk factors associated with this disease such as atherosclerosis, hypertension, diabetes and the metabolic syndrome. Oxidative stress is defined as an imbalance between the production of reactive oxygen and nitrogen species and the detoxification by the appropriate cellular systems. Reactive oxygen species induce cardiovascular dysfunction by modulating cell contraction/dilation, migration, growth/apoptosis and extracellular matrix protein turnover, which contribute to vascular and cardiac remodeling. In the last decade, the NADPH oxidase family has emerged as one of the most relevant sources of reactive oxygen species within the cardiovascular system. Recent data suggest a significant role of the genetic background in NADPH oxidase regulation. Common genetic polymorphisms within the promoter and exonic sequences of CYBA, the gene that encodes the p22(phox) subunit of the NADPH oxidase, have been characterized in the context of cardiovascular diseases. This review aims to present the current state of research into these polymorphisms with regards to their relationship to coronary artery disease.
C1 [Moreno, Maria U.; Zalba, Guillermo] Univ Navarra, Ctr Appl Med Res, Div Cardiovasc Sci, Pamplona 31008, Spain.
C3 University of Navarra
RP Zalba, G (corresponding author), Univ Navarra, Ctr Appl Med Res, Div Cardiovasc Sci, Avda Pio XII 55, Pamplona 31008, Spain.
EM gzalba@unav.es
RI ZALBA, GUILLERMO/AAB-6231-2019; Moreno, MU/F-3278-2010
OI Moreno, MU/0000-0001-5441-9462; ZALBA, GUILLERMO/0000-0003-4616-1523
FU Ministry of Culture and Science of Spain [SAF2007-62553]
FX This work was supported by the agreement between FIMA and "UTE project
   CIMA", and by grant SAF2007-62553 from the Ministry of Culture and
   Science of Spain.
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NR 112
TC 6
Z9 9
U1 0
U2 5
PU PROUS SCIENCE, SAU-THOMSON REUTERS
PI BARCELONA
PA 398 PROVENCA, 08025 BARCELONA, SPAIN
SN 0214-0934
EI 2013-0139
J9 DRUG NEWS PERSPECT
JI Drug News Perspect.
PD JUN
PY 2010
VL 23
IS 5
BP 316
EP 324
DI 10.1358/dnp.2010.23.5.1437711
PG 9
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 636XX
UT WOS:000280778900005
PM 20603655
DA 2025-06-11
ER

PT J
AU Yang, HJ
   Chang, Y
   Park, SK
   Jung, YS
   Park, JH
   Park, DI
   Cho, YK
   Ryu, S
   Sohn, CI
AF Yang, Hyo-Joon
   Chang, Yoosoo
   Park, Soo-Kyung
   Jung, Yoon Suk
   Park, Jung Ho
   Park, Dong Il
   Cho, Yong Kyun
   Ryu, Seungho
   Sohn, Chong Il
TI Nonalcoholic Fatty Liver Disease Is Associated with Increased Risk of
   Reflux Esophagitis
SO DIGESTIVE DISEASES AND SCIENCES
LA English
DT Article
ID BODY-MASS INDEX; GASTROESOPHAGEAL-REFLUX; METABOLIC SYNDROME; EROSIVE
   ESOPHAGITIS; PROSPECTIVE COHORT; OXIDATIVE STRESS; GRADED-EXERCISE;
   OBESITY; SYMPTOMS; CYTOKINES
AB Reflux esophagitis is associated with obesity and metabolic syndrome; however, the relationship between nonalcoholic fatty liver disease (NAFLD) and reflux esophagitis is unclear.
   We examined the association between NAFLD and the development of reflux esophagitis.
   Our cohort consisted of 117,377 Korean adults without reflux esophagitis at baseline who underwent a health checkup program including upper endoscopy between 2002 and 2014 and were followed annually or biennially until December 2014. NAFLD was defined as hepatic steatosis on ultrasonography in the absence of excessive alcohol use or any other identifiable cause.
   Over 520,843.2 person-years of follow-up, 22,500 participants developed reflux esophagitis (incidence density, 43.2 per 1000 person-years). In models adjusted for age and sex, the adjusted hazard ratio (aHR) (95% confidence interval [CI]) for incident reflux esophagitis in subjects with NAFLD compared to those without was 1.16 (1.13-1.20). After further adjustment for confounders of center, year of visit, smoking status, alcohol intake, regular exercise, education level, and body mass index, the association between NAFLD and incident reflux esophagitis was attenuated, but remained significant (aHR 1.06; 95% CI 1.02-1.10).
   In this large cohort of Korean men and women, participants with NAFLD exhibited increased incidence of reflux esophagitis independent of possible confounders, suggesting that NAFLD contributes to the development of reflux esophagitis.
C1 [Yang, Hyo-Joon; Park, Soo-Kyung; Jung, Yoon Suk; Park, Jung Ho; Park, Dong Il; Cho, Yong Kyun; Sohn, Chong Il] Sungkyunkwan Univ, Kangbuk Samsung Hosp, Div Gastroenterol, Dept Internal Med,Sch Med, 29 Saemunan Ro, Seoul 03181, South Korea.
   [Yang, Hyo-Joon; Park, Soo-Kyung; Jung, Yoon Suk; Park, Jung Ho; Park, Dong Il; Cho, Yong Kyun; Sohn, Chong Il] Sungkyunkwan Univ, Kangbuk Samsung Hosp, Gastrointestinal Canc Ctr, Sch Med, 29 Saemunan Ro, Seoul 03181, South Korea.
   [Chang, Yoosoo; Ryu, Seungho] Sungkyunkwan Univ, Kangbuk Samsung Hosp, Ctr Cohort Studies, Total Healthcare Ctr,Sch Med, Seoul, South Korea.
   [Chang, Yoosoo; Ryu, Seungho] Sungkyunkwan Univ, Kangbuk Samsung Hosp, Dept Occupat & Environm Med, Sch Med, Samsung Main Bldg B2,67 Sejong Daero, Seoul 04514, South Korea.
   [Chang, Yoosoo; Ryu, Seungho] Sungkyunkwan Univ, Dept Clin Res Design & Evaluat, SAIHST, Seoul, South Korea.
C3 Sungkyunkwan University (SKKU); Sungkyunkwan University (SKKU);
   Sungkyunkwan University (SKKU); Samsung Medical Center; Sungkyunkwan
   University (SKKU); Sungkyunkwan University (SKKU)
RP Sohn, CI (corresponding author), Sungkyunkwan Univ, Kangbuk Samsung Hosp, Div Gastroenterol, Dept Internal Med,Sch Med, 29 Saemunan Ro, Seoul 03181, South Korea.; Sohn, CI (corresponding author), Sungkyunkwan Univ, Kangbuk Samsung Hosp, Gastrointestinal Canc Ctr, Sch Med, 29 Saemunan Ro, Seoul 03181, South Korea.; Ryu, S (corresponding author), Sungkyunkwan Univ, Kangbuk Samsung Hosp, Ctr Cohort Studies, Total Healthcare Ctr,Sch Med, Seoul, South Korea.; Ryu, S (corresponding author), Sungkyunkwan Univ, Kangbuk Samsung Hosp, Dept Occupat & Environm Med, Sch Med, Samsung Main Bldg B2,67 Sejong Daero, Seoul 04514, South Korea.; Ryu, S (corresponding author), Sungkyunkwan Univ, Dept Clin Res Design & Evaluat, SAIHST, Seoul, South Korea.
EM sh703.yoo@gmail.com; chongil.sohn@samsung.com
RI Jung, Yoon Suk/AAB-7998-2022
OI Chang, Yoosoo/0000-0002-6945-9050; Ryu, Seungho/0000-0002-3927-8646
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NR 51
TC 14
Z9 16
U1 2
U2 7
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0163-2116
EI 1573-2568
J9 DIGEST DIS SCI
JI Dig. Dis. Sci.
PD DEC
PY 2017
VL 62
IS 12
BP 3605
EP 3613
DI 10.1007/s10620-017-4805-6
PG 9
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA FN4SL
UT WOS:000415996900042
PM 29063416
DA 2025-06-11
ER

PT J
AU Zelzer, S
   Fuchs, N
   Almer, G
   Raggam, RB
   Prüller, F
   Truschnig-Wilders, M
   Schnedl, W
   Horejsi, R
   Möller, R
   Weghuber, D
   Ille, R
   Mangge, H
AF Zelzer, Sieglinde
   Fuchs, Nina
   Almer, Gunter
   Raggam, Reinhard B.
   Prueller, Florian
   Truschnig-Wilders, Martie
   Schnedl, Wolfgang
   Horejsi, Renate
   Moeller, Reinhard
   Weghuber, Daniel
   Ille, Rottraut
   Mangge, Harald
TI High density lipoprotein cholesterol level is a robust predictor of
   lipid peroxidation irrespective of gender, age, obesity, and
   inflammatory or metabolic biomarkers
SO CLINICA CHIMICA ACTA
LA English
DT Article
DE Oxidized LDL; Obesity; HDL-cholesterol
ID CIRCULATING OXIDIZED LDL; INSULIN-RESISTANCE; ANTIBODY-LEVELS;
   ATHEROSCLEROSIS; DEFINITION
AB Background: Obesity related dyslipidemia, chronic inflammation and oxidative stress were associated with atherosclerotic sequels. We analysed oxidized low-density lipoprotein (oxLDL) plasma levels of 797 participants of the STyrian Juvenile OBesity (STYJOBS) / Early DEteCTion of Atherosclerosis (EDECTA) Study cohort aged from 5 to 50 years. The rationale of STYJOBS/EDECTA is to investigate the preclinical phase of obesity by a well defined cohort of young and middle aged overweight/obese and normal weight subjects. Methods and Results: Plasma oxLDL was analysed by ELISA (Mercodia, Sweden). In the overweight/obese (OW/OB) study group, oxLDL levels were significantly increased compared to normal weighted controls (p < 0.001). Probands with metabolic syndrome (MS) had significantly higher oxLDL levels than probands without MS; between overweight and obese participants, and between females and males, no significant difference was seen. In a multiple stepwise regression analysis including all study subjects, age, gender, anthropometric data, presence of metabolic syndrome, systolic, diastolic blood pressure, carotis communis intima media thickness, lipids, adipokines, metabolic, and inflammatory biomarkers, decreased high-density lipoprotein (HDL-cholesterol) and increased total cholesterol were the best predictors for increased oxLDL levels. Conclusion: Decreased HDL-cholesterol is an important determinant of lipid peroxidation irrespective of obesity, age, gender, SAT distribution, and inflammatory/metabolic biomarkers. (C) 2011 Elsevier B.V. All rights reserved.
C1 [Zelzer, Sieglinde; Fuchs, Nina; Almer, Gunter; Raggam, Reinhard B.; Prueller, Florian; Truschnig-Wilders, Martie; Mangge, Harald] Med Univ Graz, Clin Inst Med & Chem Lab Diag, A-8036 Graz, Austria.
   [Horejsi, Renate; Moeller, Reinhard] Med Univ Graz, Inst Physiol Chem, Ctr Physiol Med, A-8036 Graz, Austria.
   [Weghuber, Daniel] Paracelsus Private Med Sch Salzburg, Dept Pediat, Salzburg, Austria.
   [Ille, Rottraut] Karl Franzens Univ Graz, Inst Psychol, Graz, Austria.
C3 Medical University of Graz; Medical University of Graz; Paracelsus
   Private Medical University; University of Graz
RP Mangge, H (corresponding author), Med Univ Graz, Clin Inst Med & Chem Lab Diag, Auenbruggerpl 30, A-8036 Graz, Austria.
EM harald.mangge@klinikum-graz.at
RI Almer, Gunter/G-3253-2013; Weghuber, Daniel/AAN-1422-2020; Pruller,
   Florian/P-5326-2014
OI Mangge, Harald/0000-0003-4067-247X; Pruller,
   Florian/0000-0002-3388-0089; Schnedl, Wolfgang/0000-0002-5212-5230;
   Weghuber, Daniel/0000-0002-4389-0379
FU Zukunftsfond Steiermark; Austrian Nano-Initiative [0200]; Austrian FWF
   (Fonds zur Forderung der Wissenschaftlichen Forschung) [N212-NAN]
FX We gratefully acknowledge the laboratory work of Ms. Anja Stoisser and
   Ms. Melanie Korbelius, and the determination of lipid subfractions by
   Hubert Scharnagl and Sabine Paulitsch. This work was funded by the
   "Zukunftsfond Steiermark" Project "STYJOBS-Extension". Furthermore, the
   Austrian Nano-Initiative co-financed this work as part of the
   Nano-Health project (no. 0200), the sub-project NANO-PLAQUE being
   financed by the Austrian FWF (Fonds zur Forderung der Wissenschaftlichen
   Forschung, Project no. N212-NAN).
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NR 31
TC 27
Z9 28
U1 1
U2 9
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0009-8981
EI 1873-3492
J9 CLIN CHIM ACTA
JI Clin. Chim. Acta
PD JUL 15
PY 2011
VL 412
IS 15-16
BP 1345
EP 1349
DI 10.1016/j.cca.2011.03.031
PG 5
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA 781GB
UT WOS:000291917500009
PM 21515245
OA Bronze
DA 2025-06-11
ER

PT J
AU Golden, E
   Emiliano, A
   Maudsley, S
   Windham, BG
   Carlson, OD
   Egan, JM
   Driscoll, I
   Ferrucci, L
   Martin, B
   Mattson, MP
AF Golden, Erin
   Emiliano, Ana
   Maudsley, Stuart
   Windham, B. Gwen
   Carlson, Olga D.
   Egan, Josephine M.
   Driscoll, Ira
   Ferrucci, Luigi
   Martin, Bronwen
   Mattson, Mark P.
TI Circulating Brain-Derived Neurotrophic Factor and Indices of Metabolic
   and Cardiovascular Health: Data from the Baltimore Longitudinal Study of
   Aging
SO PLOS ONE
LA English
DT Article
ID CORONARY-ARTERY-DISEASE; BODY-MASS INDEX; PLASMA-CONCENTRATIONS;
   FUNCTIONAL MODULES; SURVIVAL FACTOR; HUMAN PLATELETS; SEVERE OBESITY;
   FACTOR BDNF; IN-VITRO; PROTEIN
AB Background: Besides its well-established role in nerve cell survival and adaptive plasticity, brain-derived neurotrophic factor (BDNF) is also involved in energy homeostasis and cardiovascular regulation. Although BDNF is present in the systemic circulation, it is unknown whether plasma BDNF correlates with circulating markers of dysregulated metabolism and an adverse cardiovascular profile.
   Methodology/Principal Findings: To determine whether circulating BDNF correlates with indices of metabolic and cardiovascular health, we measured plasma BDNF levels in 496 middle-age and elderly subjects (mean age similar to 70), in the Baltimore Longitudinal Study of Aging. Linear regression analysis revealed that plasma BDNF is associated with risk factors for cardiovascular disease and metabolic syndrome, regardless of age. In females, BDNF was positively correlated with BMI, fat mass, diastolic blood pressure, total cholesterol, and LDL-cholesterol, and inversely correlated with folate. In males, BDNF was positively correlated with diastolic blood pressure, triglycerides, free thiiodo-thyronine (FT3), and bioavailable testosterone, and inversely correlated with sex-hormone binding globulin, and adiponectin.
   Conclusion/Significance: Plasma BDNF significantly correlates with multiple risk factors for metabolic syndrome and cardiovascular dysfunction. Whether BDNF contributes to the pathogenesis of these disorders or functions in adaptive responses to cellular stress (as occurs in the brain) remains to be determined.
C1 [Golden, Erin; Mattson, Mark P.] NIA, Cellular & Mol Neurosci Sect, Intramural Res Program, Baltimore, MD 21224 USA.
   [Emiliano, Ana; Martin, Bronwen] NIA, Metab Unit, Intramural Res Program, Baltimore, MD 21224 USA.
   [Maudsley, Stuart] NIA, Receptor Pharmacol Unit, Intramural Res Program, Baltimore, MD 21224 USA.
   [Windham, B. Gwen; Ferrucci, Luigi] NIA, Longitudinal Studies Sect, Clin Res Branch, Intramural Res Program, Baltimore, MD 21224 USA.
   [Carlson, Olga D.; Egan, Josephine M.] NIA, Diabet Sect, Intramural Res Program, Baltimore, MD 21224 USA.
   [Driscoll, Ira] NIA, Lab Personal & Cognit, Intramural Res Program, Baltimore, MD 21224 USA.
C3 National Institutes of Health (NIH) - USA; NIH National Institute on
   Aging (NIA); National Institutes of Health (NIH) - USA; NIH National
   Institute on Aging (NIA); National Institutes of Health (NIH) - USA; NIH
   National Institute on Aging (NIA); National Institutes of Health (NIH) -
   USA; NIH National Institute on Aging (NIA); National Institutes of
   Health (NIH) - USA; NIH National Institute on Aging (NIA); National
   Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA)
RP Golden, E (corresponding author), NIA, Cellular & Mol Neurosci Sect, Intramural Res Program, Baltimore, MD 21224 USA.
EM martinbro@mail.nih.gov
RI Mattson, Mark/F-6038-2012; Maudsley, Stuart/Q-4782-2019; Ferrucci,
   Luigi/AED-9724-2022; Maudsley, Stuart/O-7565-2015
OI Martin, Bronwen/0000-0002-9185-6925; , Erin Golden/0009-0008-1345-8201;
   Ferrucci, Luigi/0000-0002-6273-1613; Maudsley,
   Stuart/0000-0002-1868-184X
FU Intramural Research Program of the National Institutes of Health (NIH)
   [5 T32 DK007751-09]; National Institute on Aging
FX This work was supported entirely by the Intramural Research Program of
   the National Institutes of Health (NIH), National Institute on Aging.
   Ana Emiliano was supported by grant number NIH 5 T32 DK007751-09. The
   funders had no role in study design, data collection and analysis,
   decision to publish, or preparation of the manuscript.
CR [Anonymous], NIH PUBLICATION
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NR 60
TC 171
Z9 177
U1 0
U2 12
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD APR 9
PY 2010
VL 5
IS 4
AR e10099
DI 10.1371/journal.pone.0010099
PG 9
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 580WU
UT WOS:000276482100015
PM 20404913
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU López-Yerena, A
   Villaplana, VD
   Badimon, L
   Vilahur, G
   Padro, T
AF Lopez-Yerena, Anallely
   Villaplana, Victoria de Santisteban
   Badimon, Lina
   Vilahur, Gemma
   Padro, Teresa
TI Probiotics: A Potential Strategy for Preventing and Managing
   Cardiovascular Disease
SO NUTRIENTS
LA English
DT Review
DE inflammation; lipid profile; functional foods; blood pressure
ID ISCHEMIC-HEART-DISEASE; METABOLIC SYNDROME; LIPID PROFILE; OXIDATIVE
   STRESS; BLOOD-PRESSURE; DOUBLE-BLIND; BIFIDOBACTERIUM-LACTIS; INTESTINAL
   MICROBIOTA; INSULIN-RESISTANCE; GUT MICROBIOTA
AB Probiotics are gaining recognition as a viable strategy for mitigating cardiovascular risk factors. Specifically, recent studies highlight their potential benefits in managing cholesterol levels, blood pressure, and inflammation, which are critical components in the prevention of cardiovascular diseases (CVD). This comprehensive review aims to elucidate the impact of probiotic consumption on major cardiovascular risk factors, including individuals with hypertension, type II diabetes mellitus, metabolic syndrome, hypercholesterolemia, and in secondary prevention in coronary artery disease. Scientific evidence based on human studies suggests that probiotic consumption is associated with positive effects on anthropometric measures, inflammation markers, blood pressure, glucose metabolism markers, lipid profiles, and endothelial function. However, these findings should be interpreted pragmatically and acknowledge the significant variability in results. This variability may be attributed to factors such as probiotic composition (single strain or multiple strains), the characteristics of the delivery matrix (food, capsules, and sachets), the duration of the intervention, the dosage regimen, and baseline health profiles of the participants. Incorporating probiotics as part of a comprehensive and healthy lifestyle approach can be considered a feasible strategy for both the prevention and management of CVD. However, further research is needed on factors influencing the effect of probiotics, such as: (i) optimal probiotic strain(s), (ii) appropriate dosage, (iii) duration of treatment, (iv) optimal delivery vehicle, and (v) sex-specific differences.
C1 [Lopez-Yerena, Anallely; Villaplana, Victoria de Santisteban; Badimon, Lina; Vilahur, Gemma; Padro, Teresa] Inst Recerca St Pau, St Quinti 77-79, Barcelona 08041, Spain.
   [Villaplana, Victoria de Santisteban] Univ Barcelona UB, Sch Pharm & Food Sci, Barcelona 08036, Spain.
   [Badimon, Lina; Vilahur, Gemma; Padro, Teresa] Inst Salud Carlos III, Ctr Invest Biomed Red Cardiovasc CIBER CV, Madrid 28029, Spain.
   [Badimon, Lina] Cardiovasc Res Fdn Hlth Prevent & Innovat FICSI, Barcelona 08017, Spain.
C3 University of Barcelona; Instituto de Salud Carlos III; CIBER - Centro
   de Investigacion Biomedica en Red; CIBERCV
RP Padro, T (corresponding author), Inst Recerca St Pau, St Quinti 77-79, Barcelona 08041, Spain.; Padro, T (corresponding author), Inst Salud Carlos III, Ctr Invest Biomed Red Cardiovasc CIBER CV, Madrid 28029, Spain.
EM naye.yerena@gmail.com; vsantisteban@santpau.cat; lina.badimon@gmail.com;
   gvilahur@santpau.cat; tpadro@santpau.cat
RI López Yerena, Anallely/GRO-2167-2022; BADIMON, LINA/O-4711-2014
OI Padro, Teresa/0000-0003-1921-954X; Lopez Yerena,
   Anallely/0000-0002-4333-9798
FU Fundacio la Marato [202329-10]; Spanish Ministry of Economy and
   Competitiveness of Science and Agencia Estatal de Investigacion
   [PID2019-107160RB-I00]; CIBERCV; MCIN; European Union
   (NextGenerationEU/PRTR);  [PID2021-128891OB-I00]
FX This work was supported by the "Fundacio la Marato"-project number
   202329-10 to TP, Spanish Ministry of Economy and Competitiveness of
   Science and Agencia Estatal de Investigacion PID2021-128891OB-I00 to
   G.V. and AEI/10.13039/501100011033-[PID2019-107160RB-I00] to L.B.;
   CIBERCV to G.V. A.L.-Y. gratefully acknowledges financial support
   through the "Juan de la Cierva-Formacion" programme funded by MCIN
   (MCIN/AEI/10.13039/501100011033) and by the European Union
   (NextGenerationEU/PRTR).
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NR 139
TC 2
Z9 2
U1 6
U2 6
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JAN
PY 2025
VL 17
IS 1
AR 52
DI 10.3390/nu17010052
PG 22
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA R8G7M
UT WOS:001393771000001
PM 39796486
OA gold
DA 2025-06-11
ER

PT J
AU Zotova, T
   Lukanina, A
   Blagonravov, M
   Tyurina, V
   Goryachev, V
   Bryk, A
   Sklifasovskaya, A
   Kurlaeva, A
AF Zotova, Tatyana
   Lukanina, Anastasia
   Blagonravov, Mikhail
   Tyurina, Veronika
   Goryachev, Vyacheslav
   Bryk, Anna
   Sklifasovskaya, Anastasia
   Kurlaeva, Anastasia
TI Features of Allostatic Load in Patients with Essential Hypertension
   without Metabolic Syndrome Depending on the Nature of Nighttime
   Decreases in Blood Pressure
SO DIAGNOSTICS
LA English
DT Article
DE essential hypertension; ABPM; allostasis; allostatic load; biological
   rhythm
ID RENIN-ANGIOTENSIN SYSTEM; GOLDEN RATIO; STRESS; MECHANISMS; PREVENTION;
   BIOMARKERS; DISEASE; HEART; NEXUS; SEX
AB Changes in the activity of the renin-angiotensin-aldosterone system are responsible for a stable shift in the regulation of the cardiovascular system in essential hypertension (EH). They can be characterized as hemodynamic allostasis. The purpose of our study was to determine the role of hemodynamic parameters in allostatic load in patients with EH without metabolic syndrome. Twenty-four hours of ambulatory blood pressure monitoring was performed, followed by linear and non-linear rhythm analysis. Based on the daily index, patients with EH were divided into two groups: group 1-patients with no significant nighttime decrease in blood pressure (BP); group 2-patients who had a nocturnal decrease in BP. The control group included healthy persons aged 25 to 69 years. A linear analysis was used to determine the mean values of systolic and diastolic BP, heart rate (HR), time load of BP, circadian index, and structural point of BP. Non-linear analysis was applied to determine the mesor, amplitude, range of oscillations and % rhythm of BP and HR. The allostatic load index (ALI) was also calculated on the basis of the corresponding biomarkers. It was found that ALI was significantly higher in groups 1 and 2 in comparison with the control group. The hemodynamic mechanisms of this increase were different.
C1 [Zotova, Tatyana; Lukanina, Anastasia; Blagonravov, Mikhail; Tyurina, Veronika; Goryachev, Vyacheslav; Bryk, Anna; Sklifasovskaya, Anastasia; Kurlaeva, Anastasia] RUDN Univ, Inst Med, 6 Miklukho Maklaya St, Moscow 117198, Russia.
C3 Peoples Friendship University of Russia
RP Blagonravov, M (corresponding author), RUDN Univ, Inst Med, 6 Miklukho Maklaya St, Moscow 117198, Russia.
EM zotova-tyu@rudn.ru; lukanina-aa@rudn.ru; blagonravov-ml@rudn.ru;
   1042210206@rudn.ru; goryachev-va@rudn.ru; bryk-aa@rudn.ru;
   sklifasovskaya-ap@rudn.ru; kurlaeva-ao@rudn.ru
RI Zotova, Tatyana/S-7775-2017; Blagonravov, Mikhail/AAR-8480-2020;
   Sklifasovskaya, Anastasia/JDH-0448-2023
OI Sklifasovskaya, Anastasia/0000-0002-0042-6015
FU RUDN University
FX No Statement Available
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   Zuther P., 2009, Chronos-Fit 1.06
NR 63
TC 0
Z9 0
U1 0
U2 2
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2075-4418
J9 DIAGNOSTICS
JI Diagnostics
PD DEC
PY 2023
VL 13
IS 23
AR 3553
DI 10.3390/diagnostics13233553
PG 12
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA AE1F6
UT WOS:001116688000001
PM 38066794
OA gold
DA 2025-06-11
ER

PT J
AU Flisiak-Jackiewicz, M
   Bobrus-Chociej, A
   Tarasów, E
   Wojtkowska, M
   Bialokoz-Kalinowska, I
   Lebensztejn, DM
AF Flisiak-Jackiewicz, Marta
   Bobrus-Chociej, Anna
   Tarasow, Eugeniusz
   Wojtkowska, Malgorzata
   Bialokoz-Kalinowska, Irena
   Lebensztejn, Dariusz Marek
TI Predictive Role of Interleukin-18 in Liver Steatosis in Obese Children
SO CANADIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
LA English
DT Article
ID NONALCOHOLIC FATTY LIVER; INSULIN-RESISTANCE; PLASMA INTERLEUKIN-18;
   METABOLIC SYNDROME; HEPATIC STEATOSIS; OXIDATIVE STRESS; SERUM FERRITIN;
   POTENTIAL ROLE; DISEASE; INFLAMMATION
AB Introduction. Interleukin-18 (IL-18) is a proinflammatory cytokine associated with metabolic syndrome (MS). Nonalcoholic fatty liver disease (NAFLD) can be recognized as a feature of MS. Material and Methods. Serum IL-18 concentration was evaluated in serum of 108 obese children, determined with ELISA, and referred to degree of liver steatosis in USG or total intrahepatic lipid content assessed by magnetic resonance proton spectroscopy ((HMRS)-H-1). Results. Fatty liver was confirmed in 89 children with USG and in 72 with (HMRS)-H-1. IL-18 concentration demonstrated significantly higher values in patients than in controls. Significant correlations between IL-18 and ALT, GGT, triglycerides, hsCRP, and the degree of liver steatosis were demonstrated. NAFLD children had significantly higher level of IL-18, ALT, GGT, HOMA-IR, waist circumference, and total lipids content in (HMRS)-H-1 than other obese children. IL-18 level was also significantly higher in obese children with advanced liver steatosis. Measurement of serum IL-18 showed ability to differentiate children with fatty liver from those without steatosis. Conclusion. Elevated serum IL-18 concentration and its correlation with hepatocyte injury, systemic inflammation, and degree of liver steatosis support role in NAFLD pathomechanism. IL-18 can be considered to play a role in predicting advanced liver steatosis and fatty liver in obese children.
C1 [Flisiak-Jackiewicz, Marta; Bobrus-Chociej, Anna; Lebensztejn, Dariusz Marek] Med Univ Bialystok, Dept Pediat Gastroenterol & Allergol, Bialystok, Poland.
   [Tarasow, Eugeniusz] Med Univ Bialystok, Dept Radiol, Bialystok, Poland.
   [Wojtkowska, Malgorzata] Univ Children Hosp, Dept Radiol, Bialystok, Poland.
   [Bialokoz-Kalinowska, Irena] Lomza State Univ Appl Sci, Lomza, Poland.
C3 Medical University of Bialystok; Medical University of Bialystok
RP Flisiak-Jackiewicz, M (corresponding author), Med Univ Bialystok, Dept Pediat Gastroenterol & Allergol, Bialystok, Poland.
EM m_flisiak@op.pl
RI Lebensztejn, Dariusz/AAE-3166-2020; Flisiak-Jackiewicz,
   Marta/U-9368-2018; Bobrus- Chociej, ANNA/S-6710-2018
OI Flisiak-Jackiewicz, Marta/0000-0001-5157-8708; Bobrus- Chociej,
   ANNA/0000-0003-2143-4978
FU Medical University of Bialystok, Poland [143-43618L, 153-43771L]
FX The study was financially supported by Grants from Medical University of
   Bialystok, Poland, nos. 143-43618L and 153-43771L.
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NR 46
TC 32
Z9 34
U1 0
U2 4
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2291-2789
EI 2291-2797
J9 CAN J GASTROENTEROL
JI Can. J. Gastroenterol. Hepatol.
PY 2018
VL 2018
AR 3870454
DI 10.1155/2018/3870454
PG 9
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA GF0HC
UT WOS:000431610000001
PM 29854715
OA Green Submitted, gold, Green Published
DA 2025-06-11
ER

PT J
AU Akhlaghi, M
AF Akhlaghi, Masoumeh
TI Non-alcoholic Fatty Liver Disease: Beneficial Effects of Flavonoids
SO PHYTOTHERAPY RESEARCH
LA English
DT Review
DE flavonoids; non-alcoholic fatty liver disease; antioxidants; insulin
   resistance; steatosis
ID VISCERAL ADIPOSE-TISSUE; FASTING PLASMA-CONCENTRATIONS; HEPATIC
   INSULIN-RESISTANCE; BODY-MASS INDEX; OXIDATIVE STRESS; GREEN TEA;
   METABOLIC SYNDROME; RAT MODEL; MITOCHONDRIAL DYSFUNCTION;
   MOLECULAR-MECHANISMS
AB Non-alcoholic fatty liver disease (NAFLD) has been known as the hepatic feature of metabolic syndrome. Extra fat depots, especially in visceral areas, develop insulin resistance as a result of mild oxidation and inflammation. Insulin resistance induces lipolysis and releases free fatty acids into the circulation, where they are transported to the liver. In the liver, free fatty acids are converted to triglycerides and accumulate, causing simple steatosis that, if left untreated, can lead to steatohepatitis, and subsequently liver necrosis and cirrhosis.Flavonoids, a group of plant compounds with incredible biological characteristics, have shown advantages in pathological conditions. Beneficial effects of flavonoids against NAFLD and its related disorders have been observed in both animal and human studies. Various mechanisms have been found for their protection. Flavonoids prevent hepatosteatosis by increasing fatty acid oxidation in the liver. They can also reduce caloric intake and decrease body weight and fat deposition in visceral tissues. Flavonoids are unique antioxidants that exert their beneficial effects through inhibition of nuclear factor B, thereby attenuating release of inflammatory cytokines, which are triggers of insulin resistance. Finally, flavonoids have shown to increase adiponectin, improve insulin sensitivity and glucose tolerance, correct dyslipidemia, and reduce blood pressure in patients with NAFLD. Copyright (c) 2016 John Wiley & Sons, Ltd.
C1 [Akhlaghi, Masoumeh] Shiraz Univ Med Sci, Sch Nutr & Food Sci, Nutr Res Ctr, Shiraz, Iran.
C3 Shiraz University of Medical Science
RP Akhlaghi, M (corresponding author), Sch Nutr & Food Sci, Nutr Res Ctr, Razi Blvd, Shiraz, Iran.
EM akhlaghi_m@sums.ac.ir
RI Akhlaghi, Masoumeh/R-4685-2017
OI Akhlaghi, Masoumeh/0000-0003-3868-0227
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NR 140
TC 58
Z9 65
U1 2
U2 40
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0951-418X
EI 1099-1573
J9 PHYTOTHER RES
JI Phytother. Res.
PD OCT
PY 2016
VL 30
IS 10
BP 1559
EP 1571
DI 10.1002/ptr.5667
PG 13
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA DZ2VT
UT WOS:000385700400002
PM 27307131
DA 2025-06-11
ER

PT J
AU Lee, GS
   Lee, LA
   Wang, CY
   Chen, NH
   Fang, TJ
   Huang, CG
   Cheng, WN
   Li, HY
AF Lee, Guo-She
   Lee, Li-Ang
   Wang, Chao-Yung
   Chen, Ning-Hung
   Fang, Tuan-Jen
   Huang, Chung-Guei
   Cheng, Wen-Nuan
   Li, Hsueh-Yu
TI The Frequency and Energy of Snoring Sounds Are Associated with Common
   Carotid Artery Intima-Media Thickness in Obstructive Sleep Apnea
   Patients
SO SCIENTIFIC REPORTS
LA English
DT Article
ID C-REACTIVE PROTEIN; CARDIOVASCULAR EVENTS; METABOLIC SYNDROME; SURROGATE
   MARKERS; OXIDATIVE STRESS; RISK; ATHEROSCLEROSIS; DISEASE; INFLAMMATION;
   SITE
AB Obstructive sleep apnea (OSA) is a known risk factor for atherosclerosis. We investigated the association of common carotid artery intima-media thickness (CCA-IMT) with snoring sounds in OSA patients. A total of 30 newly diagnosed OSA patients with no history of cardiovascular diseases were prospectively enrolled for measuring mean CCA-IMT with B-mode ultrasonography, body mass index, metabolic syndrome, 10-year cardiovascular disease risk score, high-sensitivity C-reactive protein, and homocysteine. Good-quality signals of full-night snoring sounds in an ordinary sleep condition obtained from 15 participants were further acoustically analyzed (Included group). All variables of interest were not significantly different (all p > 0.05) between the included and non-included groups except for diastolic blood pressure (p = 0.037). In the included group, CCA-IMT was significantly correlated with snoring sound energies of 0-20 Hz (r = 0.608, p = 0.036) and 652-1500 Hz (r = 0.632, p = 0.027) and was not significantly associated with that of 20-652 Hz (r = 0.366, p = 0.242) after adjustment for age and sex. Our findings suggest that underlying snoring sounds may cause carotid wall thickening and support the large-scale evaluation of snoring sound characters as markers of surveillance and for risk stratification at diagnosis.
C1 [Lee, Guo-She] Natl Yang Ming Univ, Sch Med, Fac Med, Taipei 11221, Taiwan.
   [Lee, Guo-She] Taipei City Hosp, Ren Ai Branch, Dept Otolaryngol, Taipei 10629, Taiwan.
   [Lee, Li-Ang; Fang, Tuan-Jen; Li, Hsueh-Yu] Linkou Chang Gung Mem Hosp, Sleep Ctr, Dept Otorhinolaryngol Head & Neck Surg, Tao Yuan 33305, Taiwan.
   [Lee, Li-Ang; Wang, Chao-Yung; Chen, Ning-Hung; Fang, Tuan-Jen; Li, Hsueh-Yu] Chang Gung Univ, Coll Med, Fac Med, Taoyuan 33303, Taiwan.
   [Wang, Chao-Yung] Linkou Chang Gung Mem Hosp, Sleep Ctr, Dept Cardiol, Tao Yuan 33305, Taiwan.
   [Chen, Ning-Hung] Linkou Chang Gung Mem Hosp, Sleep Ctr, Dept Thorac Med, Tao Yuan 33305, Taiwan.
   [Huang, Chung-Guei] Linkou Chang Gung Mem Hosp, Dept Lab Med, Tao Yuan 33305, Taiwan.
   [Huang, Chung-Guei] Chang Gung Univ, Coll Med, Dept Med Biotechnol & Lab Sci, Tao Yuan 33303, Taiwan.
   [Huang, Chung-Guei] Chang Gung Univ, Coll Med, Grad Inst Biomed Sci, Tao Yuan 33303, Taiwan.
   [Cheng, Wen-Nuan] Univ Taipei, Dept Sports Sci, Tai Pei 11153, Taiwan.
   [Li, Hsueh-Yu] Royal Infirm Edinburgh NHS Trust, Dept Sleep Med, Edinburgh EH16 4SA, Midlothian, Scotland.
C3 National Yang Ming Chiao Tung University; Taipei City Hospital; Chang
   Gung Memorial Hospital; Chang Gung University; Chang Gung Memorial
   Hospital; Chang Gung Memorial Hospital; Chang Gung Memorial Hospital;
   Chang Gung University; Chang Gung University; University of Edinburgh;
   Royal Infirmary of Edinburgh
RP Li, HY (corresponding author), Linkou Chang Gung Mem Hosp, Sleep Ctr, Dept Otorhinolaryngol Head & Neck Surg, Tao Yuan 33305, Taiwan.; Li, HY (corresponding author), Chang Gung Univ, Coll Med, Fac Med, Taoyuan 33303, Taiwan.; Li, HY (corresponding author), Royal Infirm Edinburgh NHS Trust, Dept Sleep Med, Edinburgh EH16 4SA, Midlothian, Scotland.
EM hyli38@cgmh.org.tw
RI Li-Ang, Lee/AAO-6876-2020; chen, jia/JLM-4733-2023; Wang,
   Chao-Yung/ABA-6757-2021
OI Fang, TuanJen/0000-0002-7805-3458
FU Ministry of Science and Technology, Taiwan, ROC
   [NSC102-2314-B-182A-082]; Linkou Chang Gung Memorial Hospital, Taoyuan,
   Taiwan [3C0661-3]
FX We express our gratitude to the study participants and for the project
   management of Mrs. Shin-Jao Lee (Department of Otorhinolaryngology-Head
   and Neck Surgery, Linkou-Chang Gung Memorial Hospital, Taoyuan, Taiwan).
   This project was supported by grants from the Ministry of Science and
   Technology, Taiwan, ROC. (NSC102-2314-B-182A-082-) and the Linkou Chang
   Gung Memorial Hospital, Taoyuan, Taiwan (grants 3C0661-3).
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NR 54
TC 28
Z9 28
U1 0
U2 6
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD JUL 29
PY 2016
VL 6
AR 30559
DI 10.1038/srep30559
PG 11
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA DS2WJ
UT WOS:000380644300001
PM 27469245
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Nascimento, H
   Alves, AI
   Coimbra, S
   Catarino, C
   Gomes, D
   Bronze-Da-Rocha, E
   Costa, E
   Rocha-Pereira, P
   Aires, L
   Mota, J
   Mansilha, HF
   Rêgo, C
   Santos-Silva, A
   Belo, L
AF Nascimento, Henrique
   Alves, Ana Ines
   Coimbra, Susana
   Catarino, Cristina
   Gomes, Diana
   Bronze-da-Rocha, Elsa
   Costa, Elisio
   Rocha-Pereira, Petronila
   Aires, Luisa
   Mota, Jorge
   Mansilha, Helena Ferreira
   Rego, Carla
   Santos-Silva, Alice
   Belo, Luis
TI Bilirubin is independently associated with oxidized LDL levels in young
   obese patients
SO DIABETOLOGY & METABOLIC SYNDROME
LA English
DT Article
DE Bilirubin; Oxidized-LDL; Oxidative stress; Atherosclerosis; Pediatric
   obesity
ID LOW-DENSITY-LIPOPROTEIN; INSULIN-RESISTANCE; METABOLIC SYNDROME; SERUM
   BILIRUBIN; CHILDREN; SUSCEPTIBILITY; ADIPONECTIN; MARKERS; HDL
AB Background: Bilirubin can prevent lipid oxidation in vitro, but the association in vivo with oxidized low-density lipoprotein (Ox-LDL) levels has been poorly explored. Our aim is to the association of Ox-LDL with total bilirubin (TB) levels and with variables related with metabolic syndrome and inflammation, in young obese individuals.
   Findings: 125 obese patients (13.4 years; 53.6% females) were studied. TB, lipid profile including Ox-LDL, markers of glucose metabolism, and levels of C-reactive protein (CRP) and adiponectin were determined. Anthropometric data was also collected.
   In all patients, Ox-LDL correlated positively with BMI, total cholesterol, LDLc, triglycerides (TG), CRP, glucose, insulin and HOMAIR; while inversely with TB and HDLc/Total cholesterol ratio (P < 0.05 for all). In multiple linear regression analysis, LDLc, TG, HDLc and TB levels were significantly associated with Ox-LDL (standardized Beta: 0.656, 0.293, -0.283, -0.164, respectively; P < 0.01 for all). After removing TG and HDLc from the analysis, HOMAIR was included in the regression model. In this new model, LDLc remained the best predictor of Ox-LDL levels (beta = 0.665, P < 0.001), followed by TB (beta = -0.202, P = 0.002) and HOMAIR (beta = 0.163, P = 0.010).
   Conclusions: Lower bilirubin levels may contribute to increased LDL oxidation in obese children and adolescents, predisposing to increased cardiovascular risk.
C1 [Nascimento, Henrique; Alves, Ana Ines; Coimbra, Susana; Catarino, Cristina; Bronze-da-Rocha, Elsa; Costa, Elisio; Santos-Silva, Alice; Belo, Luis] Univ Porto, Inst Mol & Cell Biol, Inst Mol & Cellular Biol, P-4100 Oporto, Portugal.
   [Nascimento, Henrique; Alves, Ana Ines; Coimbra, Susana; Catarino, Cristina; Gomes, Diana; Bronze-da-Rocha, Elsa; Costa, Elisio; Santos-Silva, Alice; Belo, Luis] Univ Porto, Inst Res & Innovat Hlth, Inst Invest Inovacao Saude, P-4100 Oporto, Portugal.
   [Nascimento, Henrique; Catarino, Cristina; Bronze-da-Rocha, Elsa; Costa, Elisio; Santos-Silva, Alice; Belo, Luis] Univ Porto, Fac Pharm, Dept Biol Sci, P-4100 Oporto, Portugal.
   [Coimbra, Susana] CESPU, Inst Res & Adv Training Hlth Sci & Technol, Gandra, Portugal.
   [Rocha-Pereira, Petronila] Univ Beira Interior, Hlth Sci Res Ctr, Covilha, Portugal.
   [Aires, Luisa; Mota, Jorge] Univ Porto, Fac Sport, Res Ctr Phys Act Hlth & Leisure CIAFEL, P-4100 Oporto, Portugal.
   [Aires, Luisa] High Educ Inst Maia ISMAI, S Pedro Avioso, Portugal.
   [Mansilha, Helena Ferreira] Pediat Serv Porto Hosp Ctr, Childhood & Adolescence Dept, Oporto, Portugal.
   [Rego, Carla] Univ Porto, CUF Hospital CINTESIS, Fac Med, Children & Adolescent Ctr, P-4100 Oporto, Portugal.
   [Belo, Luis] Univ Porto, Fac Farm, Dept Ciencias Biol, P-4050313 Oporto, Portugal.
C3 Universidade do Porto; Universidade do Porto; i3S - Instituto de
   Investigacao e Inovacao em Saude, Universidade do Porto; Universidade do
   Porto; Universidade da Beira Interior; Universidade do Porto; Instituto
   Universitario da Maia (ISMAI); Universidade do Porto; Universidade do
   Porto
RP Belo, L (corresponding author), Univ Porto, Inst Mol & Cell Biol, Inst Mol & Cellular Biol, Rua Campo Alegre 823, P-4100 Oporto, Portugal.
EM luisbelo@ff.up.pt
RI Aires, Luisa/L-7528-2013; Rego, Carla/L-8027-2013; Santos-Silva,
   Alice/AAC-7082-2020; Costa, Elisio/K-1990-2013; Coimbra,
   Susana/K-4466-2013; Rocha-Pereira, Petronila/K-3102-2013; Bronze da
   Rocha, Elsa/K-2723-2013; mota, jorge/B-2980-2013; Belo,
   Luis/K-5878-2013; Santos-Silva, Alice/K-2326-2013; Catarino,
   Cristina/K-5492-2013
OI Costa, Elisio/0000-0003-1158-1480; Coimbra, Susana/0000-0001-8411-8038;
   Rocha-Pereira, Petronila/0000-0002-7985-1494; Bronze da Rocha,
   Elsa/0000-0002-3571-2513; mota, jorge/0000-0001-7571-9181; Belo,
   Luis/0000-0002-3941-6850; Aires, Luisa/0000-0001-9717-4186;
   Santos-Silva, Alice/0000-0002-2565-3169; Rego,
   Carla/0000-0003-1229-8775; Catarino, Cristina/0000-0002-3229-1434;
   Gomes, Diana/0000-0002-9342-2557
FU European Regional Development Fund (FEDER, Europe) funds through the
   Operational Competitiveness Programme (COMPETE, Portugal); National
   Funds through Fundacao para a Ciencia e a Tecnologia (FCT, Portugal)
   [FCOMP-01-0124-FEDER-028613 (PTDC/DTP-DES/0393/2012)]; Fundação para a
   Ciência e a Tecnologia [PTDC/DTP-DES/0393/2012] Funding Source: FCT
FX The authors wish to thank: 1) the technician team from Porto Hospital
   Centre and Hospital Sao Joao for their expert assistance on blood
   collection, 2) all the participants that were involved in this project
   and their parents. This work was funded by European Regional Development
   Fund (FEDER, Europe) funds through the Operational Competitiveness
   Programme (COMPETE, Portugal) and by National Funds through Fundacao
   para a Ciencia e a Tecnologia (FCT, Portugal) under the project
   FCOMP-01-0124-FEDER-028613 (PTDC/DTP-DES/0393/2012).
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NR 20
TC 15
Z9 17
U1 1
U2 4
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1758-5996
J9 DIABETOL METAB SYNDR
JI Diabetol. Metab. Syndr.
PD JAN 23
PY 2015
VL 7
AR 4
DI 10.1186/1758-5996-7-4
PG 5
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA CA1OG
UT WOS:000348681200001
PM 25972929
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Espino, J
   Rodríguez, AB
   Pariente, JA
AF Espino, Javier
   Rodriguez, Ana B.
   Pariente, Jose A.
TI Melatonin and Oxidative Stress in the Diabetic State: Clinical
   Implications and Potential Therapeutic Applications
SO CURRENT MEDICINAL CHEMISTRY
LA English
DT Review
DE Melatonin; melatonin receptor; circadian rhythm; oxidative stress; type
   1 and type 2 diabetes; insulin; beta-cell
ID RECEPTOR MESSENGER-RNA; INHIBITS INSULIN-SECRETION; FASTING
   PLASMA-GLUCOSE; PANCREATIC BETA-CELLS; PINEAL MELATONIN;
   GLUCAGON-SECRETION; CIRCADIAN-RHYTHM; VITAMIN-E; IN-VITRO; METABOLIC
   SYNDROME
AB All living organisms exhibit circadian rhythms, which govern the majority of biological functions, including metabolic processes. Misalignment of these circadian rhythms increases the risk of developing metabolic diseases. Thus, disruption of the circadian system has been proven to affect the onset of type 2 diabetes mellitus (T2DM). In this context, the pineal indoleamine melatonin is a signaling molecule able to entrain circadian rhythms There is mounting evidence that suggests a link between disturbances in melatonin production and impaired insulin, glucose, lipid metabolism, and antioxidant capacity. Besides, several genetic association studies have causally associated various single nucleotide polymorphysms (SNPs) of the human MT2 receptor with increased risk of developing T2DM. Taken together, these data suggest that endogenous as well as exogenous melatonin may influence diabetes and associated metabolic disturbances not only by regulating insulin secretion but also by providing protection against reactive oxygen species (ROS) since pancreatic beta-cells are very susceptible to oxidative stress due to their low antioxidant capacity.
C1 [Espino, Javier; Rodriguez, Ana B.; Pariente, Jose A.] Univ Extremadura, Neuroimmunophysiol & Chrononutr Res Grp, Fac Sci, Dept Physiol, Badajoz, Spain.
C3 Universidad de Extremadura
RP Pariente, JA (corresponding author), Univ Extremadura, Fac Sci, Dept Physiol, Badajoz 06006, Spain.
EM pariente@unex.es
RI Pariente, Jeremie/B-2026-2016; Espino, Javier/B-6002-2017
FU Gobierno de Extremadura (European Regional Development Fund (ERDF)
   [P01401]; Ayuda a Grupos-Junta de Extremadura [GR15051-BBB021]
FX J. Espino holds a research post-doctoral fellowship from Gobierno de
   Extremadura (jointly financed by the European Regional Development Fund
   (ERDF); ref. P01401). Supported by Ayuda a Grupos-Junta de Extremadura
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NR 124
TC 19
Z9 22
U1 0
U2 7
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 0929-8673
EI 1875-533X
J9 CURR MED CHEM
JI Curr. Med. Chem.
PY 2019
VL 26
IS 22
BP 4178
EP 4190
DI 10.2174/0929867325666180410094149
PG 13
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Pharmacology &
   Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
GA IZ7CO
UT WOS:000487243500006
PM 29637854
DA 2025-06-11
ER

PT J
AU Novák, J
   Stork, M
AF Novak, Jaroslav
   Stork, Milan
TI High "Fitness Age" as a Risk Factor for Morbidity and Premature
   Mortality
SO PHYSIOLOGICAL RESEARCH
LA English
DT Article
DE Cardiorespiratory capacity; NYHA classification; VO2max; Fitness age;
   Physical activity
ID CARDIORESPIRATORY FITNESS; CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME;
   CLASSIFICATION; MEN
AB The level of cardiorespiratory capacity, as measured by maximum VO(2)max oxygen consumption, is a significant factor related to the risk of metabolic syndrome, coronary heart disease and other health disorders. A total cohort of 2901 examinations was divided into 5 groups according to the nature of physical activity: group A - endurance athletes, group B - team sports players, group C other competitive athletes, group D - recreational leisure-time athletes, group E - people with health problems. Cardiorespiratory fitness was assessed according to the VO2max and METmax parameters found in the stress test on a bicycle ergometer. A gradually increased load until exhaustion was used. While in groups A to D cases that would be classified as NYHA 1 (METmax lower than 9) were quite rare (10 cases out of 2777, i.e. 0.3 %), in groups E it was 20 % in men (16 cases out of 82) and 52 % in women (23 cases out of 44) of those examined. Accordingly, fitness age in groups A, B and C generally corresponded to a lower age than the calendar age, in groups E of both men and women, fitness age was significantly higher compared to the calendar age. High fitness age represents a significant risk of morbidity in relation to non-communicable diseases and probably also a significant limitation of their quality of life in later age.
C1 [Novak, Jaroslav] Charles Univ Prague, Dept Sports Med, Med Fac, Plzen, Czech Republic.
   [Stork, Milan] Univ West Bohemia, Dept Elect & Informat Technol RICE, Plzen, Czech Republic.
C3 Charles University Prague; University of West Bohemia Pilsen
RP Novák, J (corresponding author), Charles Univ Prague, Dept Sports Med, Med Fac, Alej Svobody 76, Plzen 32300, Czech Republic.
EM jaroslav.novak@lfp.cuni.cz
RI Novak, Jaroslav/KIJ-5865-2024
OI Novak, Jaroslav/0000-0002-2402-7000
FU Cooperation Program, research area Immunity and Infection; Department of
   Electronics and Information Technology/RICE, University of West Bohemia,
   Plzen, Czech Republic; Ministry of Education, Youth and Sports of the
   Czech Republic under the project OP VVV Electrical Engineering
   Technologies with High-Level of Embedded Intelligence
   [CZ.02.1.01/0.0/0.0/18_069/0009855]; Internal Grant Agency of University
   of West Bohemia in Plzen [SGS-2021-005]
FX This work was supported by the Cooperation Program, research area
   Immunity and Infection and by Department of Electronics and Information
   Technology/RICE, University of West Bohemia, Plzen, Czech Republic and
   by the Ministry of Education, Youth and Sports of the Czech Republic
   under the project OP VVV Electrical Engineering Technologies with
   High-Level of Embedded Intelligence, CZ.02.1.01/0.0/0.0/18_069/0009855
   and by the Internal Grant Agency of University of West Bohemia in Plzen,
   the project SGS-2021-005.
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NR 22
TC 2
Z9 2
U1 0
U2 2
PU ACAD SCIENCES CZECH REPUBLIC, INST PHYSIOLOGY
PI PRAGUE 4
PA VIDENSKA 1083, PRAGUE 4 142 20, CZECH REPUBLIC
SN 0862-8408
EI 1802-9973
J9 PHYSIOL RES
JI Physiol. Res.
PD DEC
PY 2023
VL 72
SU 5
BP S489
EP S497
DI 10.33549/physiolres.935251
PG 9
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA NB8J2
UT WOS:001198072000005
PM 38165753
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Kuhn, P
   Kalariya, HM
   Poulev, A
   Ribnicky, DM
   Jaja-Chimedza, A
   Roopchand, DE
   Raskin, I
AF Kuhn, Peter
   Kalariya, Hetalben M.
   Poulev, Alexander
   Ribnicky, David M.
   Jaja-Chimedza, Asha
   Roopchand, Diana E.
   Raskin, Ilya
TI Grape polyphenols reduce gut-localized reactive oxygen species
   associated with the development of metabolic syndrome in mice
SO PLOS ONE
LA English
DT Article
ID AKKERMANSIA-MUCINIPHILA; OXIDATIVE STRESS; GASTROINTESTINAL-TRACT;
   INSULIN SENSITIVITY; PROANTHOCYANIDINS; OBESITY; KINASE;
   BIOAVAILABILITY; HYPERGLYCEMIA; INFLAMMATION
AB High-fat diet (HFD)-induced leaky gut syndrome combined with low-grade inflammation increase reactive oxygen species (ROS) in the intestine and may contribute to dysbiosis and metabolic syndrome (MetS). Poorly bioavailable and only partially metabolizable dietary polyphenols, such as proanthocyanidins (PACs), may exert their beneficial effects on metabolic health by scavenging intestinal ROS. To test this hypothesis, we developed and validated a novel, noninvasive, in situ method for visualizing intestinal ROS using orally administered ROS-sensitive indocyanine green (ICG) dye. C57BLJ6J mice fed HFD for 10 weeks accumulated high levels of intestinal ROS compared to mice fed low-fat diet (LFD). Oral administration of poorly bioavailable grape polyphenol extract (GPE) and beta-carotene decreased HFD-induced ROS in the gut to levels comparable to LFD-fed mice, while administration of more bioavailable dietary antioxidants (alpha-lipoic acid, vitamin C, vitamin E) did not. Forty percent of administered GPE antioxidant activity was measured in feces collected over 24 h, confirming poor bioavailability and persistence in the gut. The bloom of beneficial anaerobic gut bacteria, such as Akkermansia muciniphila, associated with improved metabolic status in rodents and humans may be directly linked to protective antioxidant activity of some dietary components. These findings suggest a possible mechanistic explanation for the beneficial effects of poorly bioavailable polyphenols on metabolic health.
C1 [Kuhn, Peter; Kalariya, Hetalben M.; Poulev, Alexander; Ribnicky, David M.; Jaja-Chimedza, Asha; Raskin, Ilya] Rutgers State Univ, Dept Plant Biol, Foran Hall, New Brunswick, NJ 08901 USA.
   [Roopchand, Diana E.] Rutgers State Univ, Dept Food Sci, Inst Food Nutr & Hlth, Ctr Digest Hlth, New Brunswick, NJ USA.
C3 Rutgers University System; Rutgers University New Brunswick; Rutgers
   University System; Rutgers University New Brunswick
RP Raskin, I (corresponding author), Rutgers State Univ, Dept Plant Biol, Foran Hall, New Brunswick, NJ 08901 USA.
EM raskin@rutgers.edu
RI Poulev, Alexander/L-6613-2019
OI Raskin, Ilya/0000-0002-3025-8112; Poulev, Alexander/0000-0003-0939-0642
FU National Center for Complementary and Alternative Medicine
   [R01-AT-008618-01, 1 T32 AT004094]; Office of Dietary Supplements (ODS);
   NCCIH / ODS [P50-AT-002776-01, K01-AT008829]
FX This work was supported by R01-AT-008618-01 and 1 T32 AT004094 from the
   National Center for Complementary and Alternative Medicine to IR and by
   the Office of Dietary Supplements (ODS); DMR is funded by
   P50-AT-002776-01 from NCCIH / ODS; DER is funded by K01-AT008829 from
   NCCIH / ODS. The funders had no role in study design, data collection
   and analysis, decision to publish, or preparation of the manuscript.
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NR 54
TC 41
Z9 45
U1 1
U2 26
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD OCT 11
PY 2018
VL 13
IS 10
AR e0198716
DI 10.1371/journal.pone.0198716
PG 14
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA GW7TO
UT WOS:000447173500001
PM 30308002
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Lackey, DE
   Burk, DH
   Ali, MR
   Mostaedi, R
   Smith, WH
   Park, J
   Scherer, PE
   Seay, SA
   McCoin, CS
   Bonaldo, P
   Adams, SH
AF Lackey, Denise E.
   Burk, David H.
   Ali, Mohamed R.
   Mostaedi, Rouzbeh
   Smith, William H.
   Park, Jiyoung
   Scherer, Philipp E.
   Seay, Shundra A.
   McCoin, Colin S.
   Bonaldo, Paolo
   Adams, Sean H.
TI Contributions of adipose tissue architectural and tensile properties
   toward defining healthy and unhealthy obesity
SO AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
LA English
DT Article
DE matrix metalloproteinase; bariatric surgery; adipose inflammation; type
   2 diabetes mellitus; extracellular matrix
ID NUTRITIONALLY INDUCED OBESITY; DIET-INDUCED OBESITY; INSULIN-RESISTANCE;
   EXTRACELLULAR-MATRIX; METABOLIC SYNDROME; CATHEPSIN-S; MACROPHAGE
   ACTIVATION; COLLAGEN VI; WEIGHT-LOSS; MICE
AB The extracellular matrix (ECM) plays an important role in the maintenance of white adipose tissue (WAT) architecture and function, and proper ECM remodeling is critical to support WAT malleability to accomodate changes in energy storage needs. Obesity and adipocyte hypertrophy place a strain on the ECM remodeling machinery, which may promote disordered ECM and altered tissue integrity and could promote proinflammatory and cell stress signals. To explore these questions, new methods were developed to quantify omental and subcutaneous WAT tensile strength and WAT collagen content by three-dimensional confocal imaging, using collagen VI knockout mice as a methods validation tool. These methods, combined with comprehensive measurement of WAT ECM proteolytic enzymes, transcript, and blood analyte analyses, were used to identify unique pathophenotypes of metabolic syndrome and type 2 diabetes mellitus in obese women, using multivariate statistical modeling and univariate comparisons with weight-matched healthy obese individuals. In addition to the expected differences in inflammation and glycemic control, approximately 20 ECM-related factors, including omental tensile strength, collagen, and enzyme transcripts, helped discriminate metabolically compromised obesity. This is consistent with the hypothesis that WAT ECM physiology is intimately linked to metabolic health in obese humans, and the studies provide new tools to explore this relationship.
C1 [Lackey, Denise E.; Seay, Shundra A.; Adams, Sean H.] USDA ARS, Obes & Metab Res Unit, Western Human Nutr Res Ctr, Davis, CA 95616 USA.
   [Burk, David H.] Pennington Biomed Res Ctr, Cell Biol & Bioimaging Core, Baton Rouge, LA 70808 USA.
   [Ali, Mohamed R.; Mostaedi, Rouzbeh; Smith, William H.] Univ Calif Davis, Sch Med, Dept Surg, Davis, CA 95616 USA.
   [Park, Jiyoung; Scherer, Philipp E.] Univ Texas SW Med Ctr Dallas, Touchstone Diabet Ctr, Dallas, TX 75390 USA.
   [McCoin, Colin S.; Adams, Sean H.] Univ Calif Davis, Mol Cellular & Integrat Physiol Grad Grp, Davis, CA 95616 USA.
   [Bonaldo, Paolo] Univ Padua, Dept Histol Microbiol & Med Biotechnol, Padua, Italy.
   [Adams, Sean H.] Univ Calif Davis, Dept Nutr, Davis, CA 95616 USA.
C3 United States Department of Agriculture (USDA); Louisiana State
   University System; Louisiana State University; Pennington Biomedical
   Research Center; University of California System; University of
   California Davis; University of Texas System; University of Texas
   Southwestern Medical Center Dallas; University of California System;
   University of California Davis; University of Padua; University of
   California System; University of California Davis
RP Adams, SH (corresponding author), USDA ARS, Western Human Nutr Res Ctr, 430 W Hlth Sci Dr, Davis, CA 95616 USA.
EM sean.h.adams@ars.usda.gov
RI Burk, David/D-2056-2009; Scherer, Philipp/K-7819-2012; Ali,
   Mohamed/ABI-6395-2020; Park, Jiyoung/AAY-5995-2020; ADAMS,
   SEAN/N-9262-2018
OI McCoin, Colin/0000-0002-8557-6441; Bonaldo, Paolo/0000-0002-9571-8140;
   ADAMS, SEAN/0000-0002-9515-2319
FU US Department of Agriculture-Agricultural Research Service (USDA-ARS)
   [5306-51530-019-00]; USDA-ARS Headquarters Postdoctoral Award; National
   Institute of Diabetes and Digestive and Kidney Diseases [R01-DK-078328];
   NIH [R01-DK-55758, R01-CA-112023]; Department of Defense (USAMRMC)
   [BC085909]; COBRE [8P20-GM-103528]; NORC [2P30-DK-072476]; NIH
FX This research was supported by US Department of Agriculture-Agricultural
   Research Service (USDA-ARS) Intramural Project No. 5306-51530-019-00, a
   USDA-ARS Headquarters Postdoctoral Award (D.E. Lackey), National
   Institute of Diabetes and Digestive and Kidney Diseases Grant
   R01-DK-078328 (to S. H. Adams), and NIH Grants R01-DK-55758 and
   R01-CA-112023 (to P. E. Scherer). J. Park was supported in part by a
   fellowship from the Department of Defense (USAMRMC BC085909). This work
   utilized the facilities of the Pennington Biomedical Research Center
   Cell Biology and Bioimaging Core, which are supported in part by COBRE
   (8P20-GM-103528) and NORC (2P30-DK-072476) center grants from the NIH.
   The USDA is an equal opportunity provider and employer.
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NR 60
TC 93
Z9 99
U1 1
U2 11
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0193-1849
EI 1522-1555
J9 AM J PHYSIOL-ENDOC M
JI Am. J. Physiol.-Endocrinol. Metab.
PD FEB
PY 2014
VL 306
IS 3
BP E233
EP E246
DI 10.1152/ajpendo.00476.2013
PG 14
WC Endocrinology & Metabolism; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Physiology
GA AA4LU
UT WOS:000331067900001
PM 24302007
OA Green Published
DA 2025-06-11
ER

PT J
AU Essop, MF
   Chan, WYA
   Valle, A
   García-Palmer, FJ
   Du Toit, EF
AF Essop, M. F.
   Chan, W. Y. Anna
   Valle, A.
   Garcia-Palmer, F. J.
   Du Toit, E. F.
TI Impaired contractile function and mitochondrial respiratory capacity in
   response to oxygen deprivation in a rat model of pre-diabetes
SO ACTA PHYSIOLOGICA
LA English
DT Article
DE metabolic syndrome; mitochondrial respiration; myocardial infarction;
   obesity
ID METABOLIC SYNDROME; CARDIAC EFFICIENCY; OBESITY; HEART; ENERGETICS;
   ACIDS; MICE; DNA
AB Aim:
   Obesity is a major contributor to the global burden of disease and is closely associated with the development of type 2 diabetes and cardiovascular diseases. This study tested the hypothesis that mitochondrial respiratory capacity of the pre-diabetic heart is decreased leading to impaired contractile function and tolerance to ischaemia/reperfusion.
   Methods:
   Eight-week-old male Wistar rats were fed a high caloric diet for 16 weeks after which anthropometric, metabolic, cardiac and mitochondrial parameters were evaluated vs. age-matched lean controls. Cardiac function (working heart perfusions) and mitochondrial respiratory capacity were assessed at baseline and in response to acute oxygen deprivation.
   Results:
   Rats fed the high caloric diet exhibited increased body weight and visceral fat vs. the control group. Heart weights of obese rats were also increased. Triglyceride, fasting plasma insulin and free fatty acid levels were elevated, while high-density lipoprotein cholesterol levels were reduced in the obese group. Contractile function was attenuated at baseline and further decreased after subjecting hearts to ischaemia-reperfusion. Myocardial infarct sizes were increased while ADP phosphorylation rates were diminished in obese rats. However, no differences were found for mtDNA levels and the degree of oxidative stress-induced damage.
   Conclusions:
   These data show that decreased mitochondrial bioenergetic capacity in pre-diabetic rat hearts may impair respiratory capacity and reduce basal contractile function and tolerance to acute oxygen deprivation.
C1 [Essop, M. F.] Univ Stellenbosch, Dept Physiol Sci, ZA-7600 Stellenbosch, South Africa.
   [Chan, W. Y. Anna] Univ Cape Town, Dept Med, Hatter Heart Res Inst, Fac Hlth Sci, ZA-7925 Cape Town, South Africa.
   [Valle, A.; Garcia-Palmer, F. J.] Univ Illes Balears, Inst Salud Carlos III, Grp Metab Energet & Nutr, Palma de Mallorca, Spain.
   [Du Toit, E. F.] Univ Stellenbosch, Fac Hlth Sci, Dept Med Physiol, ZA-7505 Tygerberg, South Africa.
C3 Stellenbosch University; University of Cape Town; Universitat de les
   Illes Balears; Instituto de Salud Carlos III; Stellenbosch University
RP Essop, MF (corresponding author), Univ Stellenbosch, Dept Physiol Sci, Mike De Vries Bldg,Merriman Ave, ZA-7600 Stellenbosch, South Africa.
EM mfessop@sun.ac.za
RI du Toit, Eben/I-8074-2015; Valle, Adamo/H-7042-2017
OI Essop, Faadiel/0000-0002-8434-4294; Valle, Adamo/0000-0001-7217-2811
FU South African Medical Research Council; South African National Research
   Foundation
FX The authors thank Mr Wayne Smith for technical assistance. This work was
   supported by the South African Medical Research Council and the South
   African National Research Foundation (to M.F. Essop), and the South
   African National Research Foundation (to E.F. Du Toit).
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Z9 23
U1 0
U2 3
PU WILEY-BLACKWELL PUBLISHING, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1748-1708
J9 ACTA PHYSIOL
JI Acta Physiol.
PD DEC
PY 2009
VL 197
IS 4
BP 289
EP 296
DI 10.1111/j.1748-1716.2009.02024.x
PG 8
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA 512PX
UT WOS:000271263400003
PM 19645752
OA Green Published
DA 2025-06-11
ER

PT J
AU Pfluger, PT
   Herranz, D
   Velasco-Miguel, S
   Serrano, M
   Tschöp, MH
AF Pfluger, Paul T.
   Herranz, Daniel
   Velasco-Miguel, Susana
   Serrano, Manuel
   Tschop, Matthias H.
TI Sirt1 protects against high-fat diet-induced metabolic damage
SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF
   AMERICA
LA English
DT Article
DE inflammation; metabolism; NF kappa B; sirtuins; steatosis
ID NF-KAPPA-B; STIMULATED INSULIN-SECRETION; OXIDATIVE STRESS;
   LIVER-DISEASE; IKK-BETA; IN-VIVO; RESISTANCE; INFLAMMATION; GLUCOSE;
   OBESITY
AB The identification of new pharmacological approaches to effectively prevent, treat, and cure the metabolic syndrome is of crucial importance. Excessive exposure to dietary lipids causes inflammatory responses, deranges the homeostasis of cellular metabolism, and is believed to constitute a key initiator of the metabolic syndrome. Mammalian Sirt1 is a protein deacetylase that has been involved in resveratrol-mediated protection from high-fat diet-induced metabolic damage, but direct proof for the implication of Sirt1 has remained elusive. Here, we report that mice with moderate overexpression of Sirt1 under the control of its natural promoter exhibit fat mass gain similar to wild-type controls when exposed to a high-fat diet. Higher energy expenditure appears to be compensated by a parallel increase in food intake. Interestingly, transgenic Sirt1 mice under a high-fat diet show lower lipid-induced inflammation along with better glucose tolerance, and are almost entirely protected from hepatic steatosis. We present data indicating that such beneficial effects of Sirt1 are due to at least two mechanisms: induction of antioxidant proteins MnSOD and Nrf1, possibly via stimulation of PGC1 alpha, and lower activation of proinflammatory cytokines, such as TNF alpha and IL-6, via down-modulation of NF kappa B activity. Together, these results provide direct proof of the protective potential of Sirt1 against the metabolic consequences of chronic exposure to a high-fat diet.
C1 [Herranz, Daniel; Velasco-Miguel, Susana; Serrano, Manuel] Spanish Natl Canc Res Ctr, CNIO, Madrid 28029, Spain.
   [Pfluger, Paul T.; Tschop, Matthias H.] Univ Cincinnati, Coll Med, Genome Res Inst, Dept Psychiat,Obes Res Ctr, Cincinnati, OH 45237 USA.
C3 Centro Nacional de Investigaciones Oncologicas (CNIO); University System
   of Ohio; University of Cincinnati
RP Serrano, M (corresponding author), Spanish Natl Canc Res Ctr, CNIO, Madrid 28029, Spain.
EM mserrano@cnio.es
RI Tschoep, Matthias/I-5443-2014; Pfluger, Paul/A-3770-2019; Serrano,
   Manuel/H-2634-2015; Herranz, Daniel/L-6986-2017
OI Tschoep, Matthias/0000-0002-4744-371X; Pfluger,
   Paul/0000-0002-8118-7588; Serrano, Manuel/0000-0001-7177-9312; Herranz,
   Daniel/0000-0003-1768-5969
FU PHS HHS [NIDDK69987, NIDDK56863, NIDDK59630] Funding Source: Medline
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NR 43
TC 807
Z9 916
U1 0
U2 108
PU NATL ACAD SCIENCES
PI WASHINGTON
PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA
SN 0027-8424
J9 P NATL ACAD SCI USA
JI Proc. Natl. Acad. Sci. U. S. A.
PD JUL 15
PY 2008
VL 105
IS 28
BP 9793
EP 9798
DI 10.1073/pnas.0802917105
PG 6
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 328FV
UT WOS:000257784700061
PM 18599449
OA Green Published
DA 2025-06-11
ER

PT J
AU Mair, KM
   Gaw, R
   MacLean, MR
AF Mair, Kirsty M.
   Gaw, Rosemary
   MacLean, Margaret R.
TI Obesity, estrogens and adipose tissue dysfunction - implications for
   pulmonary arterial hypertension
SO PULMONARY CIRCULATION
LA English
DT Review
DE aromatase; metabolic syndrome; sex differences
ID VASCULAR SMOOTH-MUSCLE; BODY-MASS INDEX; INSULIN-RESISTANCE; AROMATASE
   EXPRESSION; CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; STROMAL CELLS;
   SEX-HORMONES; RISK-FACTORS; GLUCOSE-INTOLERANCE
AB Obesity is a prevalent global public health issue characterized by excess body fat. Adipose tissue is now recognized as an important endocrine organ releasing an abundance of bioactive adipokines including, but not limited to, leptin, adiponectin and resistin. Obesity is a common comorbidity amongst pulmonary arterial hypertension patients, with 30% to 40% reported as obese, independent of other comorbidities associated with pulmonary arterial hypertension (e.g. obstructive sleep apnoea). An 'obesity paradox' has been observed, where obesity has been associated with subclinical right ventricular dysfunction but paradoxically may confer a protective effect on right ventricular function once pulmonary hypertension develops. Obesity and pulmonary arterial hypertension share multiple pathophysiological mechanisms including inflammation, oxidative stress, elevated leptin (proinflammatory) and reduced adiponectin (anti-inflammatory). The female prevalence of pulmonary arterial hypertension has instigated the hypothesis that estrogens may play a causative role in its development. Adipose tissue, a major site for storage and metabolism of sex steroids, is the primary source of estrogens and circulating estrogens levels which are elevated in postmenopausal women and men with pulmonary arterial hypertension. This review discusses the functions of adipose tissue in both health and obesity and the links between obesity and pulmonary arterial hypertension. Shared pathophysiological mechanisms and the contribution of specific fat depots, metabolic and sex-dependent differences are discussed.
C1 [Mair, Kirsty M.; Gaw, Rosemary; MacLean, Margaret R.] Univ Strathclyde, Strathclyde Inst Pharm & Biomed Sci SIPBS, Glasgow, Lanark, Scotland.
C3 University of Strathclyde
RP MacLean, MR (corresponding author), Univ Strathclyde, Strathclyde Inst Pharm & Biomed Sci SIPBS, Glasgow, Lanark, Scotland.
EM mandy.maclean@strath.ac.uk
FU British Heart Foundation [RG/16/2/32153, PG/15/63/31659]
FX This work was funded by grants from the British Heart Foundation (grant
   numbers RG/16/2/32153 and PG/15/63/31659).
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NR 174
TC 67
Z9 75
U1 2
U2 5
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 2045-8932
EI 2045-8940
J9 PULM CIRC
JI Pulm. Circ.
PD JUL
PY 2020
VL 10
IS 3
AR 2045894020952019
DI 10.1177/2045894020952023
PG 21
WC Cardiac & Cardiovascular Systems; Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System
GA NU7SB
UT WOS:000573838700001
PM 32999709
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Huang, K
   Zou, CC
   Yang, XZ
   Chen, XQ
   Liang, L
AF Huang, Ke
   Zou, Chao Chun
   Yang, Xiu Zhen
   Chen, Xiu Qing
   Liang, Li
TI Carotid Intima-Media Thickness and Serum Endothelial Marker Levels in
   Obese Children With Metabolic Syndrome
SO ARCHIVES OF PEDIATRICS & ADOLESCENT MEDICINE
LA English
DT Article
ID CARDIOVASCULAR RISK-FACTORS; VON-WILLEBRAND-FACTOR; TYPE-2
   DIABETES-MELLITUS; BODY-MASS INDEX; TO-HEIGHT RATIO; INSULIN-RESISTANCE;
   OXIDATIVE STRESS; FACTOR-VIII; DYSFUNCTION; ATHEROSCLEROSIS
AB Objective: To investigate carotid intima-media thickness (IMT) and serum endothelial marker levels in obese Chinese children.
   Design: Observational and descriptive study.
   Setting: Hangzhou, China.
   Participants: A total 131 obese children, including 29 with at least 2 components of metabolic syndrome (MS) (MS group), 102 with less than 2 components of MS (obese group), and 31 nonobese children (control group) were enrolled.
   Main Outcome Measures: Intima-media thickness, von Willebrand factor (vWF) level, and thrombomodulin level.
   Results: Compared with the control group, the obese group had greater IMT and higher vWF level (P < .05 for all). The mean (SD) vWF levels in the obese, MS, and control groups were 2.08 (0.78), 2.42 (0.98), and 1.54 (0.48) IU/mL, respectively, which were significantly different (P < .001). Intima-media thickness in the obese and MS groups was significantly greater than that in the control group. Intima-media thickness in the MS group was greater than that in the obese group. Multiple regression analysis showed that ratio of waist to height, vWF level, and triglycerides level were independent determinants of IMT.
   Conclusions: Our findings suggest endothelial injury in obese children. Intima-media thickness and vWF level might be useful to identify the degree of endothelial damage.
C1 [Huang, Ke; Zou, Chao Chun; Chen, Xiu Qing; Liang, Li] Zhejiang Univ, Sch Med, Childrens Hosp, Dept Endocrinol, Hangzhou 310003, Zhejiang, Peoples R China.
   [Yang, Xiu Zhen] Zhejiang Univ, Sch Med, Childrens Hosp, Dept Ultrason Diag, Hangzhou 310003, Zhejiang, Peoples R China.
C3 Zhejiang University; Zhejiang University
RP Liang, L (corresponding author), Zhejiang Univ, Sch Med, Childrens Hosp, Dept Endocrinol, 57 Zhugan Xiang, Hangzhou 310003, Zhejiang, Peoples R China.
EM zdliangli@163.com
FU National Key Technology R&D Program of China [2009BAI80B01]; Zhejiang
   Science and Technology Agency [2008C03002-1]
FX This work was supported by the National Key Technology R&D Program of
   China (grant 2009BAI80B01) and in part by grant 2008C03002-1 from the
   Zhejiang Science and Technology Agency. Additional Contributions: We
   thank the children and their parents for participating in this research
   project. Fang Hong, MD, Guan Ping Dong, MD, Chun Lin Wang, MD, and Xiu
   Min Wang, MD, PhD, provided exceptional patient care and organization.
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TC 37
Z9 43
U1 0
U2 4
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 1072-4710
EI 1538-3628
J9 ARCH PEDIAT ADOL MED
JI Arch. Pediatr. Adolesc. Med.
PD SEP
PY 2010
VL 164
IS 9
BP 846
EP 851
DI 10.1001/archpediatrics.2010.160
PG 6
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA 646SX
UT WOS:000281564200008
PM 20819967
DA 2025-06-11
ER

PT J
AU Bagheri, H
   Ghasemi, F
   Barreto, GE
   Rafiee, R
   Sathyapalan, T
   Sahebkar, A
AF Bagheri, Hossein
   Ghasemi, Faezeh
   Barreto, George E.
   Rafiee, Rouhullah
   Sathyapalan, Thozhukat
   Sahebkar, Amirhossein
TI Effects of curcumin on mitochondria in neurodegenerative diseases
SO BIOFACTORS
LA English
DT Review
DE curcumin; mitochondrial dysfunction; mitochondrion; neurodegenerative
   diseases
ID ENDOPLASMIC-RETICULUM STRESS; INDUCED OXIDATIVE STRESS; FATTY
   LIVER-DISEASE; AMYLOID-BETA; PC12 CELLS; HIPPOCAMPAL NEURODEGENERATION;
   PROTECTS MITOCHONDRIA; PIPERINE COMBINATION; METABOLIC SYNDROME;
   SPINAL-CORD
AB Neurodegenerative diseases (NDs) result from progressive deterioration of selectively susceptible neuron populations in different central nervous system (CNS) regions. NDs are classified in accordance with the primary clinical manifestations (e.g., parkinsonism, dementia, or motor neuron disease), the anatomic basis of neurodegeneration (e.g., frontotemporal degenerations, extrapyramidal disorders, or spinocerebellar degenerations), and fundamental molecular abnormalities (e.g., mutations, mitochondrial dysfunction, and its related molecular alterations). NDs include the Alzheimer disease and Parkinson disease, among others. There is a growing evidence that mitochondrial dysfunction and its related mutations in the form of oxidative/nitrosative stress and neurotoxic compounds play major roles in the pathogenesis of various NDs. Curcumin, a polyphenol and nontoxic compound, obtained from turmeric, has been shown to have a therapeutic beneficial effect in various disorders especially on the CNS cells. It has been shown that curcumin has considerable neuro- and mitochondria-protective properties against broad-spectrum neurotoxic compounds and diseases/injury-associating NDs. In this article, we have reviewed the various effects of curcumin on mitochondrial dysfunction in NDs.
C1 [Bagheri, Hossein] Arak Univ Med Sci, Fac Med, Dept Biotechnol, Arak, Iran.
   [Ghasemi, Faezeh] High Inst Res & Educ Transfus Med, Blood Transfus Res Ctr, Tehran, Iran.
   [Barreto, George E.] Univ Limerick, Dept Biol Sci, Limerick, Ireland.
   [Barreto, George E.] Univ Limerick, Hlth Res Inst, Limerick, Ireland.
   [Rafiee, Rouhullah] Islamic Azad Univ, Sci & Res Branch, Tehran, Iran.
   [Sathyapalan, Thozhukat] Univ Hull, Hull York Med Sch, Dept Acad Diabet Endocrinol & Metab, Kingston Upon Hull, N Humberside, England.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Neurogen Inflammat Res Ctr, Mashhad, Razavi Khorasan, Iran.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Biotechnol Res Ctr, Mashhad, Razavi Khorasan, Iran.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Sch Pharm, Mashhad, Razavi Khorasan, Iran.
C3 University of Limerick; University of Limerick; Islamic Azad University;
   University of York - UK; University of Hull; Mashhad University of
   Medical Sciences; Mashhad University of Medical Sciences; Mashhad
   University of Medical Sciences
RP Ghasemi, F (corresponding author), High Inst Res & Educ Transfus Med, Blood Transfus Res Ctr, Tehran, Iran.; Sahebkar, A (corresponding author), Mashhad Univ Med Sci, Sch Med, Dept Med Biotechnol, Mashhad, Razavi Khorasan, Iran.
EM ghasemi_808@yahoo.com; sahebkara@mums.ac.ir
RI Sathyapalan, Thozhukat/J-5212-2012; Barreto, George E./LQJ-8882-2024;
   Bagheri, Hossein/JWP-3070-2024; Sahebkar, Amirhossein/B-5124-2018
OI Sathyapalan, Thozhukat/0000-0003-3544-2231; Bagheri,
   Hossein/0000-0002-5802-908X
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NR 141
TC 152
Z9 156
U1 0
U2 20
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0951-6433
EI 1872-8081
J9 BIOFACTORS
JI Biofactors
PD JAN
PY 2020
VL 46
IS 1
BP 5
EP 20
DI 10.1002/biof.1566
EA OCT 2019
PG 16
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA KF6CL
UT WOS:000488679800001
PM 31580521
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Fujii, H
   Kawada, N
AF Fujii, Hideki
   Kawada, Norifumi
TI Inflammation and fibrogenesis in steatohepatitis
SO JOURNAL OF GASTROENTEROLOGY
LA English
DT Review
DE Insulin resistance; Lipotoxicity; Adipokine; Oxidative stress; Stellate
   cell
ID FATTY LIVER-DISEASE; HEPATIC STELLATE CELLS; NECROSIS-FACTOR-ALPHA;
   RENIN-ANGIOTENSIN SYSTEM; DINUCLEOTIDE PHOSPHATE OXIDASE; ACTIVATED
   RECEPTOR-ALPHA; FARNESOID-X-RECEPTOR; NF-KAPPA-B; NONALCOHOLIC
   STEATOHEPATITIS; INSULIN-RESISTANCE
AB Nonalcoholic fatty liver disease consists of a range of disorders characterized by excess accumulation of triglyceride within the liver. Whereas simple steatosis is clinically benign, nonalcoholic steatohepatitis (NASH) often progresses to cirrhosis. Inflammation and fibrogenesis are closely inter-related and are major targets of NASH research. Experimental data have shown that inflammation in NASH is caused by insulin resistance, systemic lipotoxicity due to overnutrition, lipid metabolites, the production of proinflammatory cytokines and adipokines by visceral adipose tissue, gut-derived bacteria, and oxidative stress. In NASH-associated fibrosis, the principal cell type responsible for extracellular matrix production is recognized as the hepatic stellate cell. Although the fibrotic mechanisms underlying NASH are largely similar to those observed in other chronic liver diseases, the altered patterns of circulating adipokines, the generation of oxidative stress, and the hormonal profile associated with the metabolic syndrome might play unique roles in the fibrogenesis associated with the disease. Information on the basic pathogenesis of NASH with a focus on the generation of inflammation and fibrosis will be discussed.
C1 [Fujii, Hideki; Kawada, Norifumi] Osaka City Univ, Grad Sch Med, Dept Hepatol, Abeno Ku, Osaka 5458585, Japan.
C3 Osaka Metropolitan University
RP Kawada, N (corresponding author), Osaka City Univ, Grad Sch Med, Dept Hepatol, Abeno Ku, 1-4-3 Asahimachi, Osaka 5458585, Japan.
EM kawadanori@med.osaka-cu.ac.jp
RI FUJII, Hideki/I-1862-2019; kawada, norifumi/AAS-1367-2020
FU Ministry of Health, Labor and Welfare of Japan; Japan Society for the
   Promotion of Science [23790806]; Grants-in-Aid for Scientific Research
   [23790806] Funding Source: KAKEN
FX This work was supported by a grant from the Ministry of Health, Labor
   and Welfare of Japan to N. Kawada (2008-2010), and by a Grant-in-Aid for
   Young Scientists (B) from the Japan Society for the Promotion of Science
   through grant 23790806 to H. Fujii (2011).
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TC 122
Z9 132
U1 0
U2 22
PU SPRINGER JAPAN KK
PI TOKYO
PA CHIYODA FIRST BLDG EAST, 3-8-1 NISHI-KANDA, CHIYODA-KU, TOKYO, 101-0065,
   JAPAN
SN 0944-1174
EI 1435-5922
J9 J GASTROENTEROL
JI J. Gastroenterol.
PD MAR
PY 2012
VL 47
IS 3
BP 215
EP 225
DI 10.1007/s00535-012-0527-x
PG 11
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 934PF
UT WOS:000303455700001
PM 22310735
DA 2025-06-11
ER

PT J
AU Ochoa, MC
   Razquin, C
   Zalba, G
   Martínez-González, MA
   Martínez, JA
   Marti, A
AF Ochoa, M. C.
   Razquin, C.
   Zalba, G.
   Martinez-Gonzalez, M. A.
   Martinez, J. A.
   Marti, A.
TI G allele of the-930A&gt;G polymorphism of the CYBA gene is associated
   with insulin resistance in obese subjects
SO JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
LA English
DT Article
DE Obesity; Insulin resistance; CYBA; Case-control
ID NADPH OXIDASE; OXIDATIVE STRESS; EXPRESSION; MECHANISMS; GLUCOSE;
   PATHWAY
AB It has been shown that NADPH oxidase plays a role in oxidative stress which has been involved in the development of metabolic syndrome. The -930A/G polymorphism of the CYBA gene (that codes p22phox, a major component of the NADPH oxidase) has been associated with human hypertension and with a reduction in NADPH oxidase activity. In this work, we have examined the influence of the -930A/G polymorphism on obesity risk and insulin resistance in a case-control study of Spanish subjects (n=313). In the obese group (n=159), there was a statistically significant association between the GG genotype of the -930A/G polymorphism of the CYBA gene and fasting insulin levels and HOMA index. This outcome agrees with previous findings concerning functional analyses of this polymorphism and reinforces the hypothesis that insulin resistance is associated with oxidative stress. In conclusion, a protective effect in carriers of the -930A/G polymorphism of the p22phox gene against insulin resistance in a population of Spanish obese adults has been found.
C1 [Ochoa, M. C.; Razquin, C.; Martinez, J. A.; Marti, A.] Univ Navarra, Dept Nutr Food Sci Physiol & Toxicol, Navarra 31008, Spain.
   [Zalba, G.] Ctr Appl Med Res, Div Cardiovasc Sci, Navarra 31008, Spain.
   [Martinez-Gonzalez, M. A.] Univ Navarra, Dept Prevent Med & Publ Hlth, Navarra 31008, Spain.
C3 University of Navarra; University of Navarra; University of Navarra
RP Marti, A (corresponding author), Univ Navarra, Dept Nutr Food Sci Physiol & Toxicol, Navarra 31008, Spain.
EM amarti@unav.es
RI Martinez-Gonzalez, Miguel/AAE-7669-2019; ZALBA, GUILLERMO/AAB-6231-2019;
   Marti del Moral, Amelia/H-1192-2017; Martinez Hernandez, J
   Alfredo/K-8709-2014; Ochoa, Maria Carmen/K-4508-2017; Razquin,
   Cristina/H-2366-2017
OI Marti del Moral, Amelia/0000-0001-9832-7981; Martinez-Gonzalez, Miguel
   A./0000-0002-3917-9808; Martinez Hernandez, J
   Alfredo/0000-0001-5218-6941; Ochoa, Maria Carmen/0000-0001-9920-2144;
   Razquin, Cristina/0000-0003-3480-2645; ZALBA,
   GUILLERMO/0000-0003-4616-1523
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NR 24
TC 7
Z9 7
U1 0
U2 3
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1138-7548
EI 1877-8755
J9 J PHYSIOL BIOCHEM
JI J. Physiol. Biochem.
PD JUN
PY 2008
VL 64
IS 2
BP 127
EP 133
DI 10.1007/BF03168240
PG 7
WC Biochemistry & Molecular Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Physiology
GA 369XQ
UT WOS:000260727600004
PM 19043982
DA 2025-06-11
ER

PT J
AU Vasileva, LV
   Savova, MS
   Amirova, KM
   Dinkova-Kostova, AT
   Georgiev, MI
AF Vasileva, Liliya V.
   Savova, Martina S.
   Amirova, Kristiana M.
   Dinkova-Kostova, Albena T.
   Georgiev, Milen I.
TI Obesity and NRF2-mediated cytoprotection: Where is the missing link?
SO PHARMACOLOGICAL RESEARCH
LA English
DT Review
DE Obesity; Chronic inflammation; Pharmacotherapy; KEAP1; NRF2; Medicinal
   plants
ID HIGH-FAT DIET; INSULIN-RESISTANCE; ADIPOSE-TISSUE; LIPID-ACCUMULATION;
   HEPATIC STEATOSIS; NRF2; STRESS; TRANSCRIPTION; ACTIVATION; PROTECTION
AB The expanding dimensions of the global health crisis of overweight population has defined the term "globesity". Among the most common pathological conditions connected with excessive adiposity are hyperglycemia, insulin resistance, dyslipidemia and hypertension which result in chronic non-communicable diseases (NCD) such as metabolic syndrome (MetS), type 2 diabetes (T2D), and nonalchoholic steatohepatitis (NASH). The contribution of inflammatory-immune reactions in obesity and its related co-morbidities is unequivocal. Increased levels of free fatty acids (FFA), reactive oxygen species (ROS) and reactive nitrogen species (RNS) overloads the homeostatic system resulting in pro-inflammatory adipokines secretion, immune-activation and chronic inflammation in obesity. The cellular mechanisms of defense against oxidative stress are orchestrated by the transcription factor nuclear factor erythroid 2 p45-related factor 2 (NRF2). Excessive oxidative stress in the cell activates NRF2 which upregulates genes encoding major cytoprotective enzymes such as NAD(P)H:quinone oxidoreductase 1 (NQO1), heme oxygenase 1 (H01), and glutathione S-transferases (GST). The present review aims to clarify the interconnections between chronic inflammation, oxidative overload and NRF2-mediated cytoprotection as potential therapeutic approach in obesity.
C1 [Vasileva, Liliya V.; Savova, Martina S.; Amirova, Kristiana M.; Georgiev, Milen I.] Ctr Plant Syst Biol & Biotechnol, Dept Plant Cell Biotechnol, Plovdiv 4000, Bulgaria.
   [Savova, Martina S.; Amirova, Kristiana M.; Georgiev, Milen I.] Bulgarian Acad Sci, Stephan Angeloff Inst Microbiol, Lab Metabol, 139 Ruski Blvd, Plovdiv 4000, Bulgaria.
   [Dinkova-Kostova, Albena T.] Univ Dundee, Sch Med, Div Cellular Med, Jacqui Wood Canc Ctr, Dundee DD1 9SY, Scotland.
   [Dinkova-Kostova, Albena T.] Johns Hopkins Univ, Sch Med, Dept Pharmacol & Mol Sci, Baltimore, MD 21205 USA.
   [Dinkova-Kostova, Albena T.] Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21205 USA.
C3 Bulgarian Academy of Sciences; Stephan Angeloff Institute of
   Microbiology, Bulgarian Academy of Sciences; University of Dundee; Johns
   Hopkins University; Johns Hopkins University
RP Georgiev, MI (corresponding author), Bulgarian Acad Sci, Stephan Angeloff Inst Microbiol, Lab Metabol, 139 Ruski Blvd, Plovdiv 4000, Bulgaria.
EM milengeorgiev@gbg.bg
RI Georgiev, Milen/P-6948-2015; Mihaylova, Liliya/AAT-7804-2021; Savova,
   Martina/MGB-2678-2025; Dinkova-Kostova, Albena/AEB-8168-2022; Mihaylova,
   Liliya/I-6017-2016
OI Georgiev, Milen I./0000-0001-5248-6135; Mihaylova,
   Liliya/0000-0002-1690-1490; Dinkova-Kostova, Albena/0000-0003-0316-9859;
   Savova, Martina/0000-0002-3852-8658
FU European Union's Horizon 2020 research and innovation programme
   [PlantaSYST - SGA/CSA: 739582, FPA: 664620]
FX This project for establishment of CPSBB has received funding from the
   European Union's Horizon 2020 research and innovation programme under
   grant agreement. PlantaSYST - SGA/CSA: 739582 under FPA: 664620.
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U2 23
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 1043-6618
J9 PHARMACOL RES
JI Pharmacol. Res.
PD JUN
PY 2020
VL 156
AR 104760
DI 10.1016/j.phrs.2020.104760
PG 9
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA LP3UP
UT WOS:000534244400031
PM 32205234
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Christensen, RAG
   Kirkham, AA
AF Christensen, Rebecca A. G.
   Kirkham, Amy A.
TI Time-Restricted Eating: A Novel and Simple Dietary Intervention for
   Primary and Secondary Prevention of Breast Cancer and Cardiovascular
   Disease
SO NUTRIENTS
LA English
DT Review
DE breast cancer; cardiovascular disease; time-restricted eating;
   time-restricted feeding; intermittent fasting; metabolic syndrome;
   fasting
ID POPULATION ATTRIBUTABLE RISK; METABOLIC SYNDROME; PHYSICAL-ACTIVITY;
   ENERGY-BALANCE; BLOOD-PRESSURE; WEIGHT-LOSS; CIRCADIAN-RHYTHMS;
   GLUCOSE-TOLERANCE; OXIDATIVE STRESS; BODY-FAT
AB There is substantial overlap in risk factors for the pathogenesis and progression of breast cancer (BC) and cardiovascular disease (CVD), including obesity, metabolic disturbances, and chronic inflammation. These unifying features remain prevalent after a BC diagnosis and are exacerbated by BC treatment, resulting in elevated CVD risk among survivors. Thus, therapies that target these risk factors or mechanisms are likely to be effective for the prevention or progression of both conditions. In this narrative review, we propose time-restricted eating (TRE) as a simple lifestyle therapy to address many upstream causative factors associated with both BC and CVD. TRE is simple dietary strategy that typically involves the consumption of ad libitum energy intake within 8 h, followed by a 16-h fast. We describe the feasibility and safety of TRE and the available evidence for the impact of TRE on metabolic, cardiovascular, and cancer-specific health benefits. We also highlight potential solutions for overcoming barriers to adoption and adherence and areas requiring future research. In composite, we make the case for the use of TRE as a novel, safe, and feasible intervention for primary and secondary BC prevention, as well as tertiary prevention as it relates to CVD in BC survivors.
C1 [Christensen, Rebecca A. G.] Univ Toronto, Dalla Lana Sch Publ Hlth, Toronto, ON M5T 3M7, Canada.
   [Kirkham, Amy A.] Univ Toronto, Fac Kinesiol & Phys Educ, Toronto, ON M5S 2C9, Canada.
C3 University of Toronto; University of Toronto
RP Kirkham, AA (corresponding author), Univ Toronto, Fac Kinesiol & Phys Educ, Toronto, ON M5S 2C9, Canada.
EM r.christensen@mail.utoronto.ca; amy.kirkham@utoronto.ca
RI Kirkham, Amy/HBZ-9926-2022
OI Christensen, Rebecca/0000-0001-5212-8688; Kirkham,
   Amy/0000-0002-3847-1225
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NR 133
TC 16
Z9 18
U1 1
U2 35
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD OCT
PY 2021
VL 13
IS 10
AR 3476
DI 10.3390/nu13103476
PG 15
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA WT8IF
UT WOS:000716102300001
PM 34684476
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Martínez, AD
   Ruelas, L
   Granger, DA
AF Martinez, Airin D.
   Ruelas, Lillian
   Granger, Douglas A.
TI Association between body mass index and salivary uric acid among
   Mexican-origin infants, youth and adults: Gender and developmental
   differences
SO DEVELOPMENTAL PSYCHOBIOLOGY
LA English
DT Article
DE Hispanics/Latinos; infants and children; body mass index; gender;
   salivary uric acid
ID 3RD NATIONAL-HEALTH; METABOLIC SYNDROME; OXIDATIVE STRESS;
   BLOOD-PRESSURE; CHILDREN; PREVALENCE; LEVEL; ADOLESCENTS; CHOLESTEROL;
   EXCRETION
AB Uric acid (UA) is the end product of the metabolic breakdown of purine nucleotides. Recent studies have measured UA in saliva in relation to obesity and chronic disease risk. Given the increasing prevalence of metabolic syndrome among Latino youth, we examined gender and age differences in salivary uric acid (sUA) and weight in a sample of Mexican-origin children (n = 65, 2 months to 18 years, 49% female) and adults (n = 46, 19-58 years, 72% female). We measured weight, height, waist, and hip circumference and collected saliva samples (later assayed for sUA). Structural equation models estimated the relationship between age, developmental stage, and weight outcomes in relation to sUA levels between genders, while controlling for race. Results demonstrate that increased sUA levels were related to higher BMI percentiles in females of all ages (beta = 0.43, p < .001). There were significant differences in sUA levels between developmental stages for girls, with female toddlers having the highest sUA levels (beta = .28, p = .02). In an interaction between BMI z-score and gender between youth and adults, BMI has a larger effect on increasing sUA levels among younger girls (beta = 0.27, p < .03) and adult women (beta = 0.33, p = .02). Levels of sUA may be gender-specific in relation to BMI and developmental stage.
C1 [Martinez, Airin D.; Ruelas, Lillian] Arizona State Univ, Sch Transborder Stud, Tempe, AZ USA.
   [Granger, Douglas A.] Univ Calif Irvine, Inst Interdisciplin Saliv Biosci Res, Irvine, CA USA.
   [Granger, Douglas A.] Johns Hopkins Univ, Sch Nursing, Dept Acute & Chron Care, Baltimore, MD USA.
   [Granger, Douglas A.] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Populat Family & Reprod Hlth, Baltimore, MD USA.
   [Granger, Douglas A.] Johns Hopkins Univ, Sch Med, Dept Pediat, Baltimore, MD USA.
   [Granger, Douglas A.] Univ Nebraska, Saliva Biosci Lab, Lincoln, NE USA.
   [Granger, Douglas A.] Univ Nebraska, Dept Psychol, Lincoln, NE USA.
C3 Arizona State University; Arizona State University-Tempe; University of
   California System; University of California Irvine; Johns Hopkins
   University; Johns Hopkins University; Johns Hopkins Bloomberg School of
   Public Health; Johns Hopkins University; University of Nebraska System;
   University of Nebraska Lincoln; University of Nebraska System;
   University of Nebraska Lincoln
RP Martínez, AD (corresponding author), Arizona State Univ, Coll Liberal Arts & Sci, Sch Transborder Studies, Tempe, AZ 85782 USA.
EM admarti1@mainex1.asu.edu
FU ASU College of Liberal Arts and Sciences Seed Funding Mechanism; Program
   for Transborder Communities Seed Grant
FX ASU College of Liberal Arts and Sciences Seed Funding Mechanism; Program
   for Transborder Communities Seed Grant
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NR 53
TC 17
Z9 17
U1 0
U2 10
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0012-1630
EI 1098-2302
J9 DEV PSYCHOBIOL
JI Dev. Psychobiol.
PD MAR
PY 2017
VL 59
IS 2
BP 225
EP 234
DI 10.1002/dev.21492
PG 10
WC Developmental Biology; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Developmental Biology; Psychology
GA EQ0GW
UT WOS:000397750700008
PM 27888639
OA Green Submitted, Green Accepted
DA 2025-06-11
ER

PT J
AU Protasiewicz-Timofticiuc, DC
   Badescu, D
   Mota, M
   Stefan, AG
   Mitrea, A
   Clenciu, D
   Efrem, IC
   Rosu, MM
   Vladu, BE
   Gheonea, TC
   Mota, E
   Vladu, IM
AF Protasiewicz-Timofticiuc, Diana Cristina
   Badescu, Diana
   Mota, Maria
   Stefan, Adela Gabriela
   Mitrea, Adina
   Clenciu, Diana
   Efrem, Ion Cristian
   Rosu, Maria Magdalena
   Vladu, Beatrice Elena
   Gheonea, Theodora Claudia
   Mota, Eugen
   Vladu, Ionela Mihaela
TI Back to Roots: Dysbiosis, Obesity, Metabolic Syndrome, Type 2 Diabetes
   Mellitus, and Obstructive Sleep Apnea-Is There an Objective Connection?
   A Narrative Review
SO NUTRIENTS
LA English
DT Review
DE gut microbiome; dysbiosis; metabolic syndrome; obesity; cardiovascular
   disease; obstructive sleep apnea
ID GUT-BRAIN AXIS; VAGUS NERVE-STIMULATION; CIRCADIAN-RHYTHMS; MICROBIOTA;
   HYPERTENSION; INFLAMMATION; RESTRICTION; DISEASE; STRESS;
   NEUROINFLAMMATION
AB In recent decades, it has become clear that the gut is more than just a digestive organ; it also functions as an immune organ with regulatory capabilities and acts as a "second brain" that influences brain function due to the presence and regulatory roles of the gut microbiota (GM). The GM is a crucial component of its host and significantly impacts human health. Dysbiosis, or microbial imbalance, has been closely linked to various diseases, including gastrointestinal, neurological, psychiatric, and metabolic disorders. The aim of this narrative review is to highlight the roles of the GM in maintaining metabolic health. Sleep is a vital biological necessity, with living organisms having evolved an internal sleep-wake rhythm that aligns with a roughly 24 h light/dark cycle, and this is known as the circadian rhythm. This cycle is essential for tissue repair, restoration, and overall optimal body functioning. Sleep irregularities have become more prevalent in modern society, with fast-paced lifestyles often disrupting normal sleep patterns. Urban living factors, such as fast food consumption, shift work, exposure to artificial light and nighttime noise, medications, and social activities, can adversely affect circadian rhythms, with dysbiosis being one of the many factors incriminated in the etiology of sleep disorders.
C1 [Protasiewicz-Timofticiuc, Diana Cristina; Badescu, Diana] Cty Clin Emergency Hosp Craiova, Dept Diabet Nutr & Metab Dis, Craiova 200642, Romania.
   [Mota, Maria; Mota, Eugen] Univ Med & Pharm Craiova, Doctoral Sch, Craiova 200349, Romania.
   [Stefan, Adela Gabriela] Calafat Municipal Hosp, Calafat 205200, Romania.
   [Mitrea, Adina; Clenciu, Diana; Gheonea, Theodora Claudia; Vladu, Ionela Mihaela] Univ Med & Pharm Craiova, Fac Med, Dept Diabet, Craiova 200349, Romania.
   [Efrem, Ion Cristian] Univ Med & Pharm Craiova, Fac Dent, Dept Med Semiol, Craiova 200349, Romania.
   [Rosu, Maria Magdalena] Univ Med & Pharm Craiova, Fac Midw & Nursing, Dept Diabet, Craiova 200349, Romania.
   [Vladu, Beatrice Elena] Univ Med & Pharm Craiova, Fac Med, Craiova 200349, Romania.
C3 University of Medicine & Pharmacy of Craiova; University of Medicine &
   Pharmacy of Craiova; University of Medicine & Pharmacy of Craiova;
   University of Medicine & Pharmacy of Craiova; University of Medicine &
   Pharmacy of Craiova
RP Mitrea, A; Clenciu, D (corresponding author), Univ Med & Pharm Craiova, Fac Med, Dept Diabet, Craiova 200349, Romania.
EM diana_protasiewicz@yahoo.com; drdianabadescu@gmail.com;
   mmota53@yahoo.com; adela.firanescu@yahoo.com; adina.mitrea@umfcv.ro;
   diana.clenciu@umfcv.ro; cristian.efrem@umfcv.ro; maria.rosu@umfcv.ro;
   beatricevladu75@gmail.com; theodora.gheonea@umfcv.ro;
   eugenmota@yahoo.com; ionela.vladu@umfcv.ro
RI Gheonea, Theodora/KSM-4721-2024; Clenciu, Diana/AAA-6152-2021; Efrem,
   Ion-Cristian/ADF-7132-2022; Vladu, Mihaela/AAA-6254-2021; MITREA,
   ADINA/HOC-7812-2023; Rosu, Maria Magdalena/HZI-4735-2023
OI Rosu, Magda/0009-0000-1009-9305; Stefan, Adela
   Gabriela/0000-0003-1159-3617; Vladu, Mihaela/0000-0002-6133-4341;
   Mitrea, Adina/0000-0002-5310-3033
FU University of Medicine and Pharmacy of Craiova
FX The Article Processing Charge was funded by the University of Medicine
   and Pharmacy of Craiova.
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NR 137
TC 4
Z9 4
U1 3
U2 3
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD DEC
PY 2024
VL 16
IS 23
AR 4057
DI 10.3390/nu16234057
PG 15
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA P2S5U
UT WOS:001376474300001
PM 39683451
OA gold
DA 2025-06-11
ER

PT J
AU González-Domínguez, A
   Visiedo-García, FM
   Domínguez-Riscart, J
   González-Domínguez, R
   Mateos, RM
   Lechuga-Sancho, AM
AF Gonzalez-Dominguez, Alvaro
   Visiedo-Garcia, Francisco M.
   Dominguez-Riscart, Jesus
   Gonzalez-Dominguez, Raul
   Mateos, Rosa M.
   Lechuga-Sancho, Alfonso Maria
TI Iron Metabolism in Obesity and Metabolic Syndrome
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE anemia; childhood obesity; iron; metabolic syndrome; metabolism; obesity
ID PLASMINOGEN-ACTIVATOR INHIBITOR-1; INSULIN-RESISTANCE; CHILDHOOD
   OBESITY; CARDIOVASCULAR RISK; ADIPOSE-TISSUE; ENDOTHELIAL DYSFUNCTION;
   OVERWEIGHT CHILDREN; OXIDATIVE STRESS; BLOOD-PRESSURE; MASS INDEX
AB Obesity is an excessive adipose tissue accumulation that may have detrimental effects on health. Particularly, childhood obesity has become one of the main public health problems in the 21st century, since its prevalence has widely increased in recent years. Childhood obesity is intimately related to the development of several comorbidities such as nonalcoholic fatty liver disease, dyslipidemia, type 2 diabetes mellitus, non-congenital cardiovascular disease, chronic inflammation and anemia, among others. Within this tangled interplay between these comorbidities and associated pathological conditions, obesity has been closely linked to important perturbations in iron metabolism. Iron is the second most abundant metal on Earth, but its bioavailability is hampered by its ability to form highly insoluble oxides, with iron deficiency being the most common nutritional disorder. Although every living organism requires iron, it may also cause toxic oxygen damage by generating oxygen free radicals through the Fenton reaction. Thus, iron homeostasis and metabolism must be tightly regulated in humans at every level (i.e., absorption, storage, transport, recycling). Dysregulation of any step involved in iron metabolism may lead to iron deficiencies and, eventually, to the anemic state related to obesity. In this review article, we summarize the existent evidence on the role of the most recently described components of iron metabolism and their alterations in obesity.
C1 [Gonzalez-Dominguez, Alvaro; Visiedo-Garcia, Francisco M.; Mateos, Rosa M.; Lechuga-Sancho, Alfonso Maria] Puerta Mar Univ Hosp, Biomed Res & Innovat Inst Cadiz INiBICA, Inflammat Nutr Metab & Oxidat Stress Study Grp IN, Res Unit, Cadiz 11009, Spain.
   [Dominguez-Riscart, Jesus; Lechuga-Sancho, Alfonso Maria] Puerta Mar Univ Hosp, Dept Pediat, Pediat Endocrinol, Cadiz 11009, Spain.
   [Gonzalez-Dominguez, Raul] Univ Huelva, Fac Expt Sci, Dept Chem, Huelva 21007, Spain.
   [Mateos, Rosa M.] Univ Cadiz, Area Biochem & Mol Biol, Dept Biomed Biotechnol & Publ Hlth, Cadiz 11519, Spain.
   [Lechuga-Sancho, Alfonso Maria] Univ Cadiz, Med Sch, Dept Child & Mother Hlth & Radiol, Area Pediat, Cadiz 11002, Spain.
C3 Universidad de Cadiz; Hospital Universitario Puerta del Mar; Universidad
   de Cadiz; Hospital Universitario Puerta del Mar; Universidad de Huelva;
   Universidad de Cadiz; Universidad de Cadiz
RP Lechuga-Sancho, AM (corresponding author), Puerta Mar Univ Hosp, Biomed Res & Innovat Inst Cadiz INiBICA, Inflammat Nutr Metab & Oxidat Stress Study Grp IN, Res Unit, Cadiz 11009, Spain.; Lechuga-Sancho, AM (corresponding author), Puerta Mar Univ Hosp, Dept Pediat, Pediat Endocrinol, Cadiz 11009, Spain.; Lechuga-Sancho, AM (corresponding author), Univ Cadiz, Med Sch, Dept Child & Mother Hlth & Radiol, Area Pediat, Cadiz 11002, Spain.
EM alvaro.gonzalez@inibica.es; franciscom.visiedo@inibica.es;
   jesus.dominguezriscart@gmail.com; raul.gonzalez@dqcm.uhu.es;
   rosa.mateos@uca.es; alfonso.lechuga@uca.es
RI González Domínguez, Álvaro/HJH-1098-2023; Lechuga-Sancho,
   Alfonso/M-2712-2015; Visiedo Garcia, Francisco/M-3712-2014; Mateos, Rosa
   Maria/M-5213-2015; Gonzalez-Dominguez, Raul/E-5125-2016
OI Lechuga-Sancho, Alfonso/0000-0001-5861-6041; Gonzalez Dominguez,
   Alvaro/0000-0002-7080-4245; Dominguez Riscart,
   Jesus/0000-0002-6948-7940; Visiedo Garcia,
   Francisco/0000-0001-7834-0169; Mateos, Rosa Maria/0000-0002-9853-1103;
   Gonzalez-Dominguez, Raul/0000-0002-7640-8833
FU Spanish Government through the Carlos III Health Institute (Sanitary
   Research Fund (FIS)) [PI18/01316]; Biomedical Research and Innovation
   Institute of Cadiz (INiBICA) [LII19/16IN-CO24]
FX This research was funded by Spanish Government through the Carlos III
   Health Institute (Sanitary Research Fund (FIS)), code PI18/01316. A G-D
   is supported by an intramural grant from the Biomedical Research and
   Innovation Institute of Cadiz (INiBICA), code LII19/16IN-CO24.
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NR 160
TC 125
Z9 130
U1 2
U2 31
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD AUG
PY 2020
VL 21
IS 15
AR 5529
DI 10.3390/ijms21155529
PG 27
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA NM4NZ
UT WOS:000568076200001
PM 32752277
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Thuzar, M
   Halim, MA
   Stowasser, M
AF Thuzar, Moe
   Halim, Muthanna Abdul
   Stowasser, Michael
TI The mineralocorticoid system, cardiometabolic health and its interplay
   with adipose tissue
SO JOURNAL OF ENDOCRINOLOGY
LA English
DT Review
DE adipose tissue; aldosterone; angiotensin; cardiometabolic health;
   metabolic syndrome; metabolism; mineralocorticoid; mineralocorticoid
   receptor
ID PLASMA-ALDOSTERONE LEVELS; ANGIOTENSINOGEN GENE-EXPRESSION; CONVERTING
   ENZYME-INHIBITION; DIET-INDUCED THERMOGENESIS; INSULIN-RESISTANCE;
   METABOLIC SYNDROME; DIABETES-MELLITUS; OXIDATIVE STRESS; BLOOD-PRESSURE;
   ADIPOCYTE DYSFUNCTION
AB The mineralocorticoid system, comprising the renin-angiotensin-aldosterone system (RAAS) and associated receptors, is traditionally viewed as a regulator of sodium and fluid balance and blood pressure (BP), with the main mineralocorticoid hormone aldosterone acting via the mineralocorticoid receptor (MR) in distal renal tubules. Over the past few decades, there has been a wider understanding of the role of the mineralocorticoid system in regulating both classical BP-dependent and non-BP-dependent systemic effects. Mounting evidence indicates the novel role of the mineralocorticoid system in cardiometabolic health, with excess mineralocorticoid system activity being associated with adiposity, diabetes, insulin resistance and cardiovascular diseases independent of its effect on BP, and RAAS blockade and MR antagonists offering protection against cardiometabolic dysfunction. The metabolic manifestations of mineralocorticoid system overactivation are mainly mediated by their interactions with adipose tissue, which orchestrates energy, lipids, and glucose homeostasis via effects on the functions of brown and white adipocytes and immune cells. Adipose tissue can, in turn, influence mineralocorticoid system activity by harboring its own RAAS system and by releasing mineralocorticoid-secretory factors/adipokines, resulting in further progression of cardiometabolic dysfunction. This article discusses the interplay between the mineralocorticoid system and adipose tissue in the pathophysiology of cardiometabolic diseases.
C1 [Thuzar, Moe; Halim, Muthanna Abdul; Stowasser, Michael] Univ Queensland, Endocrine Hypertens Res Ctr, Frazer Inst, Brisbane, Qld, Australia.
   [Thuzar, Moe; Halim, Muthanna Abdul; Stowasser, Michael] Princess Alexandra Hosp, Brisbane, Qld, Australia.
   [Thuzar, Moe] Princess Alexandra Hosp, Dept Endocrinol & Diabet, Brisbane, Qld, Australia.
C3 University of Queensland; Princess Alexandra Hospital; Princess
   Alexandra Hospital
RP Thuzar, M (corresponding author), Univ Queensland, Endocrine Hypertens Res Ctr, Frazer Inst, Brisbane, Qld, Australia.; Thuzar, M (corresponding author), Princess Alexandra Hosp, Brisbane, Qld, Australia.; Thuzar, M (corresponding author), Princess Alexandra Hosp, Dept Endocrinol & Diabet, Brisbane, Qld, Australia.
EM m.thuzar@uq.edu.au
RI Thuzar, Moe/P-8576-2014
OI Thuzar, Moe/0000-0001-6052-6096
FU Royal Australasian College of Physicians-Australian Diabetes Society;
   Metro South Health Research Support Scheme; Postgraduate Scholarship
   from the University of Queensland
FX MT is supported by a Research Establishment Fellowship from the Royal
   Australasian College of Physicians-Australian Diabetes Society and a
   Research Program Grant from the Metro South Health Research Support
   Scheme. MAH is supported by a Postgraduate Scholarship from the
   University of Queensland.
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NR 140
TC 0
Z9 0
U1 4
U2 4
PU BIOSCIENTIFICA LTD
PI BRISTOL
PA STARLING HOUSE, 1600 BRISTOL PARKWAY N, BRISTOL, ENGLAND
SN 0022-0795
EI 1479-6805
J9 J ENDOCRINOL
JI J. Endocrinol.
PD NOV 1
PY 2024
VL 263
IS 2
AR e240119
DI 10.1530/JOE-24-0119
PG 13
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA M6O9Q
UT WOS:001358721000002
PM 39283910
DA 2025-06-11
ER

PT J
AU Ajdzanovic, VZ
   Milosevic, VL
   Spasojevic, IB
AF Ajdzanovic, Vladimir Z.
   Milosevic, Verica Lj.
   Spasojevic, Ivan B.
TI Glucocorticoid excess and disturbed hemodynamics in advanced age: the
   extent to which soy isoflavones may be beneficial
SO GENERAL PHYSIOLOGY AND BIOPHYSICS
LA English
DT Review
DE Advanced age; Glucocorticoids; Cardiovascular parameters; Hemodynamics;
   Soy isoflavones
ID SPONTANEOUSLY HYPERTENSIVE-RATS; TYROSINE KINASE INHIBITOR;
   ELECTRON-SPIN-RESONANCE; NITRIC-OXIDE SYNTHASE; ACTH CELLS; METABOLIC
   SYNDROME; INSULIN-SECRETION; MEMBRANE-FLUIDITY; POTENTIAL IMPACT;
   LIPID-METABOLISM
AB Advanced age is often accompanied by glucocorticoid excess which contributes to the pathogenesis of the metabolic syndrome associated with some hemodynamic disorders. Impaired central regulation of stress hormones secretion and increased glucocorticoids/adrenal androgens ratio trigger hyperglycemia, elevated blood lipids and visceral fat accumulation, associated with hypertension and increased blood viscosity, all of which represent cardiovascular morbidity factors in this age. Finding the adequate therapeutic solutions is set as an imperative in the treatment of listed symptoms. Biologically active soy isoflavones, exhibiting estrogen- and membrane-receptor agonistic/antagonistic activity, and antioxidative and tyrosine kinase/steroidogenic enzyme inhibiting effects, appear as alternative therapeutics for various ageing-related diseases. It has been shown that soy isoflavones reduce some of the listed risk factors, while affecting the hemodynamic group of cardiovascular parameters directly, as well as indirectly via endocrine perturbations. Soy isoflavones may reverse the glucocorticoids/adrenal androgens ratio, lower serum cholesterol, slow the development of atherosclerotic plaque formation, inhibit platelet aggregation, increase cardiac contractility, but they may have diverse effects on blood viscosity and may increase triglyceride levels. Herein, we present the projection of soy isoflavones-based therapy of glucocorticoid excess and disturbed hemodynamics in advanced age, concluding that although promising, it requires the impartial approach and certain precautions.
C1 [Ajdzanovic, Vladimir Z.; Milosevic, Verica Lj.] Univ Belgrade, Inst Biol Res Sinisa Stankovic, Belgrade 11060, Serbia.
   [Spasojevic, Ivan B.] Univ Belgrade, Inst Multidisciplinary Res, Belgrade 11060, Serbia.
C3 University of Belgrade; University of Belgrade
RP Ajdzanovic, VZ (corresponding author), Univ Belgrade, Inst Biol Res Sinisa Stankovic, 142 Despot Stefan Blvd, Belgrade 11060, Serbia.
EM avlada@ibiss.bg.ac.rs
OI Ajdzanovic, Vladimir/0000-0002-6540-9603
FU Ministry of Education, Science and Technological Development of the
   Republic of Serbia [173009, 173014]
FX This work was supported by the Ministry of Education, Science and
   Technological Development of the Republic of Serbia, Grant numbers
   173009 and 173014.
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NR 75
TC 14
Z9 14
U1 0
U2 5
PU GENERAL PHYSIOL AND BIOPHYSICS
PI BRATISLAVA
PA INST OF MOLEC PHYSIOL GENETICS SLOVAK ACAD OF SCI VLARSKA 5, 83334
   BRATISLAVA, SLOVAKIA
SN 0231-5882
EI 1338-4325
J9 GEN PHYSIOL BIOPHYS
JI Gen. Physiol. Biophys.
PD DEC
PY 2012
VL 31
IS 4
BP 367
EP 374
DI 10.4149/gpb_2012_041
PG 8
WC Biochemistry & Molecular Biology; Biophysics; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Physiology
GA 049KG
UT WOS:000311981300002
PM 23255662
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Bezy, O
   Tran, TT
   Pihlajämaki, J
   Suzuki, R
   Emanuelli, B
   Winnay, J
   Mori, MA
   Haas, J
   Biddinger, SB
   Leitges, M
   Goldfine, AB
   Patti, ME
   King, GL
   Kahn, CR
AF Bezy, Olivier
   Tran, Thien T.
   Pihlajamaki, Jussi
   Suzuki, Ryo
   Emanuelli, Brice
   Winnay, Jonathan
   Mori, Marcelo A.
   Haas, Joel
   Biddinger, Sudha B.
   Leitges, Michael
   Goldfine, Allison B.
   Patti, Mary Elizabeth
   King, George L.
   Kahn, C. Ronald
TI PKCδ regulates hepatic insulin sensitivity and hepatosteatosis in mice
   and humans
SO JOURNAL OF CLINICAL INVESTIGATION
LA English
DT Article
ID PROTEIN-KINASE-C; DIET-INDUCED OBESITY; RECEPTOR SUBSTRATE-1;
   SKELETAL-MUSCLE; PHOSPHOINOSITIDE 3-KINASE; METABOLIC SYNDROME;
   GLUCOSE-TRANSPORT; OXIDATIVE STRESS; RESISTANT MICE; FATTY LIVER
AB C57BL/6J and 129S6/Sv (B6 and 129) mice differ dramatically in their susceptibility to developing diabetes in response to diet- or genetically induced insulin resistance. A major locus contributing to this difference has been mapped to a region on mouse chromosome 14 that contains the gene encoding PKC delta. Here, we found that PKC delta expression in liver was 2-fold higher in B6 versus 129 mice from birth and was further increased in B6 but not 129 mice in response to a high-fat diet. PRKCD gene expression was also elevated in obese humans and was positively correlated with fasting glucose and circulating triglycerides. Mice with global or liver-specific inactivation of the Prkcd gene displayed increased hepatic insulin signaling and reduced expression of gluconeogenic and lipogenic enzymes. This resulted in increased insulin-induced suppression of hepatic gluconeogenesis, improved glucose tolerance, and reduced hepatosteatosis with aging. Conversely, mice with liver-specific overexpression of PKC delta developed hepatic insulin resistance characterized by decreased insulin signaling, enhanced lipogenic gene expression, and hepatosteatosis. Therefore, changes in the expression and regulation of PKC delta between strains of mice and in obese humans play an important role in the genetic risk of hepatic insulin resistance, glucose intolerance, and hepatosteatosis; and thus PKC delta may be a potential target in the treatment of metabolic syndrome.
C1 [Bezy, Olivier; Tran, Thien T.; Suzuki, Ryo; Emanuelli, Brice; Winnay, Jonathan; Mori, Marcelo A.; Haas, Joel; Biddinger, Sudha B.; Goldfine, Allison B.; Patti, Mary Elizabeth; King, George L.; Kahn, C. Ronald] Joslin Diabet Ctr, Boston, MA 02215 USA.
   [Bezy, Olivier; Tran, Thien T.; Suzuki, Ryo; Emanuelli, Brice; Winnay, Jonathan; Mori, Marcelo A.; Haas, Joel; Biddinger, Sudha B.; Goldfine, Allison B.; Patti, Mary Elizabeth; King, George L.; Kahn, C. Ronald] Harvard Univ, Sch Med, Boston, MA 02215 USA.
   [Pihlajamaki, Jussi] Univ Eastern Finland, Dept Med, Kuopio, Finland.
   [Pihlajamaki, Jussi] Univ Eastern Finland, Dept Clin Nutr, Kuopio, Finland.
   [Pihlajamaki, Jussi] Kuopio Univ Hosp, SF-70210 Kuopio, Finland.
   [Biddinger, Sudha B.] Harvard Univ, Sch Med, Childrens Hosp Boston, Div Endocrinol, Boston, MA USA.
   [Leitges, Michael] Univ Oslo, Biotechnol Ctr Oslo, Oslo, Norway.
C3 Harvard University; Harvard University Medical Affiliates; Joslin
   Diabetes Center, Inc.; Harvard University; Harvard Medical School;
   University of Eastern Finland; University of Eastern Finland; Kuopio
   University Hospital; University of Eastern Finland; University of
   Eastern Finland Hospital; Harvard University; Harvard University Medical
   Affiliates; Boston Children's Hospital; Harvard Medical School;
   University of Oslo
RP Kahn, CR (corresponding author), Joslin Diabet Ctr, 1 Joslin Pl, Boston, MA 02215 USA.
EM c.ronald.kahn@joslin.harvard.edu
RI Haas, Joel/R-6379-2018; Kahn, Ronald/AAY-2435-2021; Suzuki,
   Ryo/AAA-2736-2019; Leitges, Michael/AAN-1953-2021; Mori,
   Marcelo/R-2881-2018; Emanuelli, Brice/M-2097-2016
OI Mori, Marcelo/0000-0001-7112-5263; Leitges, Michael/0000-0003-4203-6995;
   Patti, Mary-Elizabeth/0000-0002-8163-3429; Bezy,
   Olivier/0000-0003-4367-5043; Emanuelli, Brice/0000-0001-5795-5666; Haas,
   Joel/0000-0002-0028-5988; Pihlajamaki, Jussi/0000-0002-6241-6859
FU NIH [DK31036, DK33201]; American Diabetes Association; Grants-in-Aid for
   Scientific Research [23689047] Funding Source: KAKEN
FX The authors thank Michael Rourk and Graham Smith for animal technical
   assistance. This work was supported by the NIH grants DK31036 and
   DK33201, an American Diabetes Association mentor-based award, and the
   Mary K. Iacocca Professorship to C.R. Kahn.
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NR 54
TC 117
Z9 136
U1 0
U2 12
PU AMER SOC CLINICAL INVESTIGATION INC
PI ANN ARBOR
PA 2015 MANCHESTER RD, ANN ARBOR, MI 48104 USA
SN 0021-9738
EI 1558-8238
J9 J CLIN INVEST
JI J. Clin. Invest.
PD JUN
PY 2011
VL 121
IS 6
BP 2504
EP 2517
DI 10.1172/JCI46045
PG 14
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 772LB
UT WOS:000291234300049
PM 21576825
OA Bronze, Green Accepted, Green Published
DA 2025-06-11
ER

PT J
AU Tilg, H
   Moschen, A
AF Tilg, Herbert
   Moschen, Alexander
TI Update on nonalcoholic fatty liver disease: genes involved in
   nonalcoholic fatty liver disease and associated inflammation
SO CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE
LA English
DT Article
DE environment; heritability; inflammation; nonalcoholic steatohepatitis;
   patatin-like phospholipase 3
ID GENOME-WIDE ASSOCIATION; NECROSIS-FACTOR-ALPHA; INSULIN-RESISTANCE;
   PROMOTER POLYMORPHISMS; CRYPTOGENIC CIRRHOSIS; METABOLIC SYNDROME;
   JAPANESE PATIENTS; NATURAL-HISTORY; CHINESE PEOPLE; COMMON VARIANT
AB Purpose of review
   Nonalcoholic fatty liver disease (NAFLD) is one of the most prevalent liver diseases worldwide. Advanced age, extensive overweight and a number of features of the metabolic syndrome are associated with NAFLD severity. The cause of NAFLD is considered multifactorial with a substantial genetic component.
   Recent findings
   Family members of children with NAFLD demonstrate a higher risk for NAFLD. Whereas such an association only suggests that familial factors are major determinants of whether or not an individual will develop NAFLD, recent genome-wide association studies were able to identify first candidate genes. An allele in patatin-like phospholipase 3, encoding a protein of unknown function with homology to lipid acyl hydrolases, is strongly associated with increased hepatic fat and inflammation. Apolipoprotein C3 gene variants are also associated with NAFLD and insulin resistance. Several other genetic variants have been identified, although with less convincing evidence. These genetic variants involve molecules regulating insulin signaling, lipid metabolism, oxidative stress or fibrogenesis. Furthermore, genetic variants of several cytokines and adipocytokines have been associated with NAFLD.
   Summary
   Several genetic factors such as patatin-like phospholipase 3 or apolipoprotein C3 have been recently characterized in NAFLD. Further studies to identify their interaction with environmental factors are eagerly warranted.
C1 [Tilg, Herbert; Moschen, Alexander] Innsbruck Med Univ, Christian Doppler Res Lab Gut Inflammat, A-6020 Innsbruck, Austria.
C3 Medical University of Innsbruck
RP Tilg, H (corresponding author), Innsbruck Med Univ, Christian Doppler Res Lab Gut Inflammat, Anichstr 35, A-6020 Innsbruck, Austria.
EM Herbert.Tilg@i-med.ac.at
RI Moschen, Alexander/ABF-2267-2021; Tilg, Herbert/AEO-9569-2022
OI Moschen, Alexander R/0000-0003-3598-7848
FU Christian Doppler Research Society
FX This work was supported by the Christian Doppler Research Society.
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NR 57
TC 32
Z9 47
U1 0
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1363-1950
J9 CURR OPIN CLIN NUTR
JI Curr. Opin. Clin. Nutr. Metab. Care
PD JUL
PY 2010
VL 13
IS 4
BP 391
EP 396
DI 10.1097/MCO.0b013e32833a87cc
PG 6
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 621LA
UT WOS:000279579100007
PM 20473151
DA 2025-06-11
ER

PT J
AU Fauste, E
   Rodrigo, S
   Rodríguez, L
   Donis, C
   García, A
   Barbas, C
   Alvarez-Millán, JJ
   Panadero, MI
   Otero, P
   Bocos, C
AF Fauste, Elena
   Rodrigo, Silvia
   Rodriguez, Lourdes
   Donis, Cristina
   Garcia, Antonia
   Barbas, Coral
   Alvarez-Millan, Juan J.
   Panadero, Maria, I
   Otero, Paola
   Bocos, Carlos
TI FGF21-protection against fructose-induced lipid accretion and oxidative
   stress is influenced by maternal nutrition in male progeny
SO JOURNAL OF FUNCTIONAL FOODS
LA English
DT Article
DE Fructose; Fetal programming; FGF21; Liver; Adipose tissue; Oxidative
   stress
ID GROWTH-FACTOR 21; INDUCED DYSLIPIDEMIA; INSULIN-RESISTANCE; OBESITY;
   FGF21; EXPRESSION; FEMALE; PLASMA; DIET; TRIGLYCERIDES
AB Fructose intake from added sugars correlates with the epidemic rise in metabolic syndrome. Nevertheless, consumption of beverages sweetened with fructose is allowed in gestation. We have studied how adult male progeny from control (C/F), fructose- (F/F) and glucose-fed (G/F) mothers respond to liquid fructose (10% wt/ vol), and compared them to the control group (C/C). Interestingly, plasma levels of fibroblast growth factor 21 (FGF21) were augmented in fructose-fed males, mainly in F/F group. FGF21 has proven to be a protective agent against steatosis and oxidative stress. Accordingly, FGF21 protected against fructose-induced lipid accumulation in livers of C/F and F/F males, but not in G/F. However, fructose-induced lipid oxidation was found in the adipose tissue of F/F males due to an impaired response of their antioxidant system. Maternal carbohydrate intake does influence the adult male offspring's response to liquid fructose presumably by affecting the FGF21 function.
C1 [Fauste, Elena; Rodrigo, Silvia; Rodriguez, Lourdes; Donis, Cristina; Panadero, Maria, I; Otero, Paola; Bocos, Carlos] Univ San Pablo CEU, CEU Univ, Fac Farm, Madrid, Spain.
   [Garcia, Antonia; Barbas, Coral] Univ San Pablo CEU, Fac Farm, Ctr Metabol & Bioanal CEMBIO, Madrid, Spain.
   [Alvarez-Millan, Juan J.] CQS Lab, Madrid, Spain.
C3 San Pablo CEU University; San Pablo CEU University
RP Bocos, C (corresponding author), Univ San Pablo CEU, Fac Farm, Madrid 28668, Spain.
EM carbocos@ceu.es
RI Donis, Cristina/ABF-9806-2020; Fauste, Elena/AAT-8282-2020; Otero,
   Paola/H-9150-2015; Garcia, Antonia/C-4296-2008; Barbas,
   Coral/K-3871-2014; BOCOS, CARLOS/B-8460-2015; Panadero, Maria
   I./L-4262-2017
OI Garcia, Antonia/0000-0002-1521-8489; Fauste, Elena/0000-0002-5783-3092;
   Barbas, Coral/0000-0003-4722-491X; BOCOS, CARLOS/0000-0003-0364-5958;
   Panadero, Maria I./0000-0003-0459-3539; Donis Rodriguez,
   Cristina/0000-0003-2558-9539
FU Ministerio de Ciencia, Innovacion y Universidades (MICINN)
   [SAF2017-89537-R]; European Community FEDER funds; FUSP-CEU fellowship;
   FPU fellowship from MICINN
FX The authors thank Jose M. Garrido and his team for their help in
   handling the rats, and Brian Crilly for his editorial help. This work
   was supported by a grant from Ministerio de Ciencia, Innovacion y
   Universidades (MICINN) (SAF2017-89537-R), and the European Community
   FEDER funds. Silvia Rodrigo was supported with a FUSP-CEU fellowship.
   Elena Fauste is supported with a FPU fellowship from MICINN.
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NR 57
TC 4
Z9 4
U1 0
U2 6
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1756-4646
EI 2214-9414
J9 J FUNCT FOODS
JI J. Funct. Food.
PD JAN
PY 2020
VL 64
AR 103676
DI 10.1016/j.jff.2019.103676
PG 9
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA KE3WY
UT WOS:000508491000070
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Özgen, IT
   Torun, E
   Ergen, A
   Cesur, Y
   Karagedik, H
   Zeybek, Ü
   Aksu, MS
   Öktem, F
AF Ozgen, Ilker Tolga
   Torun, Emel
   Ergen, Arzu
   Cesur, Yasar
   Karagedik, Hande
   Zeybek, Umit
   Aksu, Mehmet Sirin
   Oktem, Faruk
TI Myeloperoxidase 463 G&gt;A and superoxide dismutase Ala16Val gene
   polymorphisms in obese children
SO TURKISH JOURNAL OF PEDIATRICS
LA English
DT Article
DE manganese superoxide dismutase; Myeloperoxidase; oxidative stress;
   insulin resistance
ID OXIDATIVE STRESS; INSULIN-RESISTANCE; ASSOCIATION; CANCER; MECHANISMS;
   BIOLOGY; GROWTH; DIET
AB The aim of the study was to determine the role of MnSOD Ala16Val and MPO G-463A gene polymorphisms in the pathogenesis of metabolic syndrome in obese children.
   A total of 97 obese children with insulin resistance and, as a control group, 96 healthy children were enrolled in the study.
   In the obese group, AA, AV and VV genotype frequencies of the MnSOD gene and GG, GA and AA genotype frequencies of the MPO gene were not significantly different from the frequencies found in the control group (p= 0.555 and 0.530, respectively). In the obese group, children who carry both VV (for MnSOD) and GG (for MPO) alleles (n= 26) had higher HOMA-IR levels (6.51 +/- 3.91 vs 5.03 +/- 2.12) than those of all other genotype combinations (n= 71) (p= 0.013).
   Children who have the maximum risk of developing oxidative stress with the combination of the VV (for MnSOD) and GG (for MPO) genotypes had higher HOMA-IR levels, suggesting these polymorphisms may lead to insulin resistance.
C1 [Ozgen, Ilker Tolga; Cesur, Yasar; Aksu, Mehmet Sirin] Bezmialem Vakif Univ, Fac Med, Div Pediat Endocrinol, Istanbul, Turkey.
   [Oktem, Faruk] Bezmialem Vakif Univ, Fac Med, Div Pediat Nephrol, Istanbul, Turkey.
   [Torun, Emel] Bezmialem Vakif Univ, Fac Med, Dept Pediat, Istanbul, Turkey.
   [Ergen, Arzu; Karagedik, Hande; Zeybek, Umit] Istanbul Univ, Inst Expt Med, Dept Mol Med, Istanbul, Turkey.
C3 Bezmialem Vakif University; Bezmialem Vakif University; Bezmialem Vakif
   University; Istanbul University
RP Özgen, IT (corresponding author), Bezmialem Vakif Univ, Fac Med, Div Pediat Endocrinol, Istanbul, Turkey.
EM drtolgaozgen@yahoo.com
RI Karagedik, Hande/Q-6170-2017; ergen, arzu/P-6554-2019; zeybek,
   Ümit/LWJ-6279-2024; torun, emel/NKP-0985-2025; Ozgen,
   Ilker/LKK-2184-2024
OI ergen, arzu/0000-0001-5736-8453; karagedik, emine
   hande/0000-0002-0905-1977; Ozgen, Ilker Tolga/0000-0001-6592-9652
FU Bezmialem Vakif University foundation
FX This study was supported by the Bezmialem Vakif University foundation.
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NR 34
TC 0
Z9 0
U1 0
U2 14
PU TURKISH J PEDIATRICS
PI ANKARA
PA P K 66 SAMANPAZARI, 06240 ANKARA, TURKEY
SN 0041-4301
J9 TURKISH J PEDIATR
JI Turk. J. Pediatr.
PD SEP-OCT
PY 2014
VL 56
IS 5
BP 511
EP 517
PG 7
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA CJ1OM
UT WOS:000355253300008
PM 26022587
DA 2025-06-11
ER

PT J
AU Musso, G
   Gambino, R
   Cassader, M
AF Musso, Giovanni
   Gambino, Roberto
   Cassader, Maurizio
TI Recent insights into hepatic lipid metabolism in non-alcoholic fatty
   liver disease (NAFLD)
SO PROGRESS IN LIPID RESEARCH
LA English
DT Review
DE Lipogenesis; Fatty acid transport protein; Nuclear receptors; Oxidative
   stress; Endocannabinoids; Kinetics; VLDL secretion
ID TRIGLYCERIDE TRANSFER PROTEIN; ACID-BINDING PROTEIN;
   ACTIVATED-RECEPTOR-ALPHA; LOW-DENSITY-LIPOPROTEIN; STEAROYL-COA
   DESATURASE-1; ENDOPLASMIC-RETICULUM STRESS; PHOSPHATIDYLETHANOLAMINE
   N-METHYLTRANSFERASE; FARNESOID-X-RECEPTOR; DIET-INDUCED OBESITY; ORPHAN
   NUCLEAR RECEPTOR
AB Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in Western countries and is considered the hepatic manifestation of metabolic syndrome. The hallmark of NAFLD is hepatic neutral lipid accumulation, mainly triacylglycerol, in the absence of significant ethanol consumption, viral infection or other specific etiologies. Hepatic lipid accumulation results from an imbalance between lipid availability (from circulating lipid uptake or de novo lipogenesis) and lipid disposal (via free fatty acid oxidation or triglyceride-rich lipoprotein secretion) and eventually triggers lipoperoxidative stress and hepatic injury. Each of these steps is altered in NAFLD, although to a different extent. Regulation of these pathways is complex and involves nuclear receptors, membrane transport proteins and cellular enzymes. We will review available data on different steps of hepatic lipid metabolism in NAFLD and recent advances in understanding molecular mechanisms underlying hepatic fat accumulation in these subjects. (C) 2008 Elsevier Ltd. All rights reserved.
C1 [Musso, Giovanni] Gradenigo Hosp, I-10132 Turin, Italy.
   [Gambino, Roberto; Cassader, Maurizio] Univ Turin, Dept Internal Med, I-10124 Turin, Italy.
C3 Humanitas Hospital Gradenigo; University of Turin
RP Musso, G (corresponding author), Gradenigo Hosp, Cso Regina Margherita 8, I-10132 Turin, Italy.
EM giovanni_musso@yahoo.it
RI Musso, Giovanni/AAB-7884-2022; GAMBINO, Roberto/AAC-7517-2022
FU Piedmont Region Funds Comitato Interministeriale per la Programmazione
   Economica
FX This work was funded in part by the Piedmont Region Funds Comitato
   Interministeriale per la Programmazione Economica 2008.
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NR 351
TC 565
Z9 644
U1 2
U2 195
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0163-7827
EI 1873-2194
J9 PROG LIPID RES
JI Prog. Lipid Res.
PD JAN
PY 2009
VL 48
IS 1
BP 1
EP 26
DI 10.1016/j.plipres.2008.08.001
PG 26
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA 395ZZ
UT WOS:000262563300001
PM 18824034
DA 2025-06-11
ER

PT J
AU Preuss, HG
   Echard, B
   Bagchi, D
   Perricone, NV
   Yamashita, E
AF Preuss, Harry G.
   Echard, Bobby
   Bagchi, Debasis
   Perricone, Nicholas V.
   Yamashita, Eiji
TI Astaxanthin lowers blood pressure and lessens the activity of the
   renin-angiotensin system in Zucker Fatty Rats
SO JOURNAL OF FUNCTIONAL FOODS
LA English
DT Article
DE Astaxanthin; Angiotensin-2; Renin-angiotensin; Captopril; Metabolism;
   Blood pressure
ID METABOLIC SYNDROME; DNA-DAMAGE; INSULIN; MITOCHONDRIA; SENSITIVITY;
   INHIBITION; MECHANISM; SUCROSE
AB The ability of astaxanthin to favorably influence the renin-angiotensin system (RAS), blood pressure (BP), and metabolic parameters in Zucker Fatty Rats (ZFR) was examined. In separate experiments, 96 ZFR were equally divided into four groups: control, captopril (30 mg/kg), low astaxanthin (5 mg/kg) and high astaxanthin (25 mg/kg). RAS and insulin systems were examined following recovery from heat stress. RAS was lower in test groups; however, there was no evidence of enhanced insulin sensitivity. Test groups decreased SBP (systolic blood pressure) significantly compared to the control. The tests carried out suggested that RAS was involved in the ability of astaxanthin to lower BP. Astaxanthin at high dosage influenced circulating TNF-alpha and MCP-1 and lessened fat oxidation in liver and kidneys. Thus, astaxanthin may be considered as a good stress reducer with regards to heat stress. Astaxanthin's effects on RAS indicate it might overcome perturbations associated with increased activity, especially those related to the cardiovascular system. (C) 2008 Elsevier Ltd. All rights reserved.
C1 [Preuss, Harry G.; Echard, Bobby] Georgetown Univ, Med Ctr, Dept Physiol, Washington, DC 20057 USA.
   [Preuss, Harry G.; Echard, Bobby; Yamashita, Eiji] Georgetown Univ, Med Ctr, Dept Med, Washington, DC 20057 USA.
   [Bagchi, Debasis] Univ Houston, Dept Pharmacol & Pharmaceut Sci, Houston, TX 77204 USA.
   [Perricone, Nicholas V.] Michigan State Univ, Coll Human Med, E Lansing, MI 48824 USA.
   [Yamashita, Eiji] Fuji Chem Ind Co Ltd, Div Life Sci, Toyama 9300397, Japan.
   Georgetown Univ, Med Ctr, Dept Pathol, Washington, DC 20057 USA.
C3 Georgetown University; Georgetown University; University of Houston
   System; University of Houston; Michigan State University; Michigan State
   University College of Human Medicine; Georgetown University
RP Preuss, HG (corresponding author), Georgetown Univ, Med Ctr, Dept Physiol, Basic Sci Bldg,Room 231B,3900 Reservoir Rd, Washington, DC 20057 USA.
EM preusshg@georgetown.edu
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NR 41
TC 26
Z9 27
U1 1
U2 10
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1756-4646
EI 2214-9414
J9 J FUNCT FOODS
JI J. Funct. Food.
PD JAN
PY 2009
VL 1
IS 1
BP 13
EP 22
DI 10.1016/j.jff.2008.09.001
PG 10
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA 683YP
UT WOS:000284514500003
OA hybrid
DA 2025-06-11
ER

PT J
AU Javed, H
   Meeran, MFN
   Jha, NK
   Ashraf, GM
   Ojha, S
AF Javed, Hayate
   Meeran, Mohamed Fizur Nagoor
   Jha, Niraj Kumar
   Ashraf, Ghulam Md
   Ojha, Shreesh
TI Sesamol: A Phenolic Compound of Health Benefits and Therapeutic Promise
   in Neurodegenerative Diseases
SO CURRENT TOPICS IN MEDICINAL CHEMISTRY
LA English
DT Review
DE Sesamol; Sesame seeds; Antioxidant; Parkinson's disease; Alzheimer's
   disease; Huntington's disease
ID MITOCHONDRIAL-DNA DELETIONS; INDUCED COGNITIVE DEFICITS; OXIDATIVE
   STRESS; SUBSTANTIA-NIGRA; HUNTINGTONS-DISEASE; PARKINSONS-DISEASE;
   NEUROPROTECTIVE STRATEGIES; BIOCHEMICAL-ALTERATIONS; INFLAMMATORY
   RESPONSE; DOPAMINERGIC-NEURONS
AB Sesamol, one of the key bioactive ingredients of sesame seeds (sesamum indicum L.), is responsible for many of its possible nutritional benefits. Both the Chinese and Indian medical systems have recognized the therapeutic potential of sesame seeds. It has been shown to have significant therapeutic potential against oxidative stress, inflammatory diseases, metabolic syndrome, neurodegeneration, and mental disorders. Sesamol is a benign molecule that inhibits the expression of inflammatory indicators like numerous enzymes responsible for inducing inflammation, protein kinases, cytokines, and redox status. This review summarises the potential beneficial effects of sesamol against neurological diseases including Alzheimer's disease (AD), Parkinson's disease (PD), and Huntington's disease (HD). Recently, sesamol has been shown to reduce amyloid peptide accumulation and attenuate cognitive deficits in AD models. Sesamol has also been demonstrated to reduce the severity of PD and HD in animal models by decreasing oxidative stress and inflammatory pathways. The mechanism of sesamol's pharmacological activities against neurodegenerative diseases will also be discussed in this review.
C1 [Javed, Hayate] United Arab Emirates Univ, Coll Med & Hlth Sci, Dept Anat, POB 17666, Al Ain, U Arab Emirates.
   [Meeran, Mohamed Fizur Nagoor; Ojha, Shreesh] United Arab Emirates Univ, Coll Med & Hlth Sci, Dept Pharmacol & Therapeut, POB 17666, Al Ain, U Arab Emirates.
   [Jha, Niraj Kumar] Sharda Univ, Sch Engn & Technol SET, Dept Biotechnol, Greater Noida 201310, Uttar Pradesh, India.
   [Jha, Niraj Kumar] Uttaranchal Univ, Sch Appl & Life Sci SALS, Dept Biotechnol, Dehra Dun 248007, India.
   [Jha, Niraj Kumar] Chandigarh Univ, Dept Biotechnol Engn & Food Technol, Mohali 140413, India.
   [Ashraf, Ghulam Md] Univ Sharjah, Sharjah Inst Med Res, Coll Hlth Sci, Dept Med Lab Sci, Sharjah 27272, U Arab Emirates.
C3 United Arab Emirates University; United Arab Emirates University; Sharda
   University; Uttaranchal University; Chandigarh University; University of
   Sharjah
RP Javed, H (corresponding author), United Arab Emirates Univ, Coll Med & Hlth Sci, Dept Anat, POB 17666, Al Ain, U Arab Emirates.; Ojha, S (corresponding author), United Arab Emirates Univ, Coll Med & Hlth Sci, Dept Pharmacol & Therapeut, POB 17666, Al Ain, U Arab Emirates.
EM hayatjvd@gmail.com; shreeshojha@uaeu.ac.ae
RI Jha, Niraj/AEN-2948-2022; Ashraf, Ghulam Md/H-9485-2012
OI Ashraf, Ghulam Md/0000-0002-9820-2078
FU United Arab Emirates University [12R121, 12R104]
FX The authors are thankful to the United Arab Emirates University for the
   research grants# 12R121 and 12R104 to Shreesh Ojha.
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NR 120
TC 0
Z9 0
U1 4
U2 8
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1568-0266
EI 1873-4294
J9 CURR TOP MED CHEM
JI Curr. Top. Med. Chem.
PY 2024
VL 24
IS 9
BP 797
EP 809
DI 10.2174/0115680266273944231213070916
EA DEC 2023
PG 13
WC Chemistry, Medicinal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA OQ5J7
UT WOS:001150012600001
PM 38141184
DA 2025-06-11
ER

PT J
AU Kobori, M
   Takahashi, Y
   Akimoto, Y
   Sakurai, M
   Matsunaga, I
   Nishimuro, H
   Ippoushi, K
   Oike, H
   Ohnishi-Kameyama, M
AF Kobori, Masuko
   Takahashi, Yumiko
   Akimoto, Yukari
   Sakurai, Mutsumi
   Matsunaga, Izumi
   Nishimuro, Haruno
   Ippoushi, Katsunari
   Oike, Hideaki
   Ohnishi-Kameyama, Mayumi
TI Chronic high intake of quercetin reduces oxidative stress and induces
   expression of the antioxidant enzymes in the liver and visceral adipose
   tissues in mice
SO JOURNAL OF FUNCTIONAL FOODS
LA English
DT Article
DE Quercetin; Antioxidant enzymes; Nuclear factor E2-related factor 2;
   Malondialdehyde; Oxidative stress
ID HEPATIC GENE-EXPRESSION; IN-VIVO; METABOLIC SYNDROME; FLAVONOID INTAKE;
   OXIDANT STRESS; OBESITY; IDENTIFICATION; PROFILE; IMPACT; SAFETY
AB To obtain knowledge regarding the safe intake of quercetin-rich functional foods, we examined the effect of chronic and high intake of quercetin. We fed mice a standard diet containing 0.05 or 1% quercetin for 20 weeks. Both quercetin diets did not significantly affect the body weight, fat accumulation, and blood components. However, 0.05% quercetin significantly increased the glutathione/oxidized glutathione ratio in the liver. The 1% quercetin diet reduced the lipid peroxidation marker malondialdehyde in the liver, epididymal adipose tissues, and small intestine. The 1% quercetin diet significantly induced the expression of the antioxidant enzymes Gpx1, Cat, and Sod1 in the liver and Gpx1 and Cat in the epididymal adipose tissues. The transcription factor nuclear factor E2-related factor 2 (Nrf2) was slightly induced in the nuclear fraction of the livers of mice fed the 1% quercetin diet. Quercetin may induce antioxidant enzymes by activating the Nrf2 pathway in the liver. (C) 2015 Elsevier Ltd. All rights reserved.
C1 [Kobori, Masuko; Takahashi, Yumiko; Akimoto, Yukari; Sakurai, Mutsumi; Matsunaga, Izumi; Nishimuro, Haruno; Ippoushi, Katsunari; Oike, Hideaki; Ohnishi-Kameyama, Mayumi] Natl Agr & Food Res Org, Natl Food Res Inst, Tsukuba, Ibaraki 3058642, Japan.
   [Nishimuro, Haruno] Seitoku Univ, Matsudo, Chiba 2718555, Japan.
C3 National Food Research Institute - Japan; National Agriculture & Food
   Research Organization - Japan
RP Kobori, M (corresponding author), Natl Agr & Food Res Org, Natl Food Res Inst, 2-1-12 Kannondai, Tsukuba, Ibaraki 3058642, Japan.
EM kobori@affrc.go.jp
RI Oike, Hideaki/C-6457-2009
OI Oike, Hideaki/0000-0002-6139-5726
FU Ministry of Agriculture, Forestry and Fisheries (MAFF); Research Project
   on Development of Agricultural Products and Foods with Health-promoting
   benefits (NARO); Ministry of Education, Culture, Sports, Science, and
   Technology, Japan [24501024]; Grants-in-Aid for Scientific Research
   [24501024] Funding Source: KAKEN
FX This work was financially supported in part by a grant from the Ministry
   of Agriculture, Forestry and Fisheries (MAFF) research project for new
   demand creation of agricultural products, by a grant from the Research
   Project on Development of Agricultural Products and Foods with
   Health-promoting benefits (NARO), and by a grant-in-aid for Science
   Research (24501024) from the Ministry of Education, Culture, Sports,
   Science, and Technology, Japan.
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NR 43
TC 69
Z9 75
U1 2
U2 51
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1756-4646
J9 J FUNCT FOODS
JI J. Funct. Food.
PD MAY
PY 2015
VL 15
BP 551
EP 560
DI 10.1016/j.jff.2015.04.006
PG 10
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA CJ1JV
UT WOS:000355240800053
DA 2025-06-11
ER

PT J
AU Hong, Y
   Chen, S
   Zhang, JM
AF Hong, Y.
   Chen, S.
   Zhang, J-M
TI Hydrogen as a Selective Antioxidant: a Review of Clinical and
   Experimental Studies
SO JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
LA English
DT Review
DE OXIDATIVE STRESS; ANTIOXIDANT; HYDROGEN; HYDROGEN-SATURATED WATER
ID ISCHEMIA-REPERFUSION INJURY; REDUCING OXIDATIVE STRESS; RICH SALINE
   PROTECTS; RAT MODEL; MOLECULAR-HYDROGEN; INTESTINAL
   ISCHEMIA/REPERFUSION; HYPOXIA-ISCHEMIA; WATER; MICE; GAS
AB Oxidative stress is implicated in the pathogenesis of many diseases; however, currently used antioxidants have a high toxicity that constrains administration to a narrow window of therapeutic dosage. There is a clear need for more effective and safer antioxidants. Diatomic hydrogen (H-2) was proposed as a novel antioxidant that selectively reduces levels of toxic reactive-oxygen species. Recently, many studies have reported that H-2 (inhaled or orally ingested, typically as approximately 0.8 mM H-2-saturated water), can exert beneficial effects in diverse animal models of ischaemia-reperfusion injury, and inflammatory and neurological disease. In the clinic, oral administration of H-2-saturated water is reported to improve lipid and glucose metabolism in subjects with diabetes or impaired glucose tolerance; promising results have also been obtained in reducing inflammation in haemodialysis patients and treating metabolic syndrome. These studies suggest H-2 has selective antioxidant properties, and can exert antiapoptotic, anti-inflammatory and antiallergy effects. This review summarizes recent research findings and mechanisms concerning the therapeutic potential of H-2.
RP Zhang, JM (corresponding author), Zhejiang Univ, Dept Neurosurg, Affiliated Hosp 2, Sch Med, 88 Jiefang Rd, Hangzhou 310009, Zhejiang, Peoples R China.
EM zjm135vip@sina.com
FU Natural Science Foundation of Zhejiang [Z2090200]
FX We acknowledge the support of the Natural Science Foundation of Zhejiang
   Z2090200).
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NR 46
TC 107
Z9 129
U1 2
U2 44
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0300-0605
EI 1473-2300
J9 J INT MED RES
JI J. Int. Med. Res.
PD NOV-DEC
PY 2010
VL 38
IS 6
BP 1893
EP 1903
DI 10.1177/147323001003800602
PG 11
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA 730SK
UT WOS:000288054400002
PM 21226992
OA Green Submitted, Bronze
DA 2025-06-11
ER

PT J
AU Chou, CL
   Li, CH
   Fang, TC
AF Chou, Chu-Lin
   Li, Ching-Hao
   Fang, Te-Chao
TI Benefits of Valsartan and Amlodipine in Lipolysis through PU.1
   Inhibition in Fructose-Induced Adiposity
SO NUTRIENTS
LA English
DT Article
DE activating transcription factor 3; adiposity; calcium channel blocker;
   fructose; PU; 1; renin-angiotensin system blocker
ID CHANNEL BLOCKER AMLODIPINE; DECREASES ADIPOCYTE SIZE; II RECEPTOR
   BLOCKER; INSULIN-RESISTANCE; METABOLIC SYNDROME; OXIDATIVE STRESS;
   TISSUE; DIFFERENTIATION; IMPROVEMENT; CELLS
AB High fructose intake has been implicated in obesity and metabolic syndrome, which are related to increased cardiovascular mortality. However, few studies have experimentally examined the role of renin-angiotensin system blockers and calcium channel blockers (CCB) in obesity. We investigated the effects of valsartan (an angiotensin II receptor blocker) and amlodipine (a CCB) on lipolysis through the potential mechanism of PU.1 inhibition. We observed that high fructose concentrations significantly increased adipose size and triglyceride, monoacylglycerol lipase, adipose triglyceride lipase, and stearoyl-CoA desaturase-1 (SCD1), activating transcription factor 3 and PU.1 levels in adipocytes in vitro. Subsequently, PU.1 inhibitor treatment was able to reduce triglyceride, SCD1, and PU.1 levels. In addition, elevated levels of triglyceride and PU.1, stimulated by a high fructose concentration, decreased with valsartan and amlodipine treatment. Overall, these findings suggest that high fructose concentrations cause triacylglycerol storage in adipocytes through PU.1-mediated activation. Furthermore, valsartan and amlodipine treatment reduced triacylglycerol storage in adipocytes by inhibiting PU.1 activation in high fructose concentrations in vitro. Thus, the benefits of valsartan and amlodipine in lipolysis may be through PU.1 inhibition in fructose-induced adiposity, and PU.1 inhibition might have a potential therapeutic role in lipolysis in fructose-induced obesity.
C1 [Chou, Chu-Lin; Fang, Te-Chao] Taipei Med Univ, Coll Med, Sch Med, Dept Internal Med, Taipei 110, Taiwan.
   [Chou, Chu-Lin; Fang, Te-Chao] Taipei Med Univ, TMU Res Ctr Urol & Kidney, Taipei 110, Taiwan.
   [Chou, Chu-Lin] Taipei Med Univ, Shuang Ho Hosp, Dept Internal Med, Div Nephrol, New Taipei 235, Taiwan.
   [Chou, Chu-Lin] Taipei Med Univ, Hsin Kuo Min Hosp, Dept Internal Med, Div Nephrol, Taoyuan 320, Taiwan.
   [Li, Ching-Hao] Taipei Med Univ, Coll Med, Sch Med, Dept Physiol, Taipei 110, Taiwan.
   [Li, Ching-Hao] Taipei Med Univ, Coll Med, Grad Inst Med Sci, Taipei 110, Taiwan.
   [Fang, Te-Chao] Taipei Med Univ, Coll Med, Grad Inst Clin Med, Taipei 110, Taiwan.
   [Fang, Te-Chao] Taipei Med Univ, Taipei Med Univ Hosp, Dept Internal Med, Div Nephrol, Taipei 110, Taiwan.
C3 Taipei Medical University; Taipei Medical University; Taipei Medical
   University; Shuang Ho Hospital; Taipei Medical University; Taipei
   Medical University; Taipei Medical University; Taipei Medical
   University; Taipei Medical University Hospital
RP Fang, TC (corresponding author), Taipei Med Univ, Coll Med, Sch Med, Dept Internal Med, Taipei 110, Taiwan.; Fang, TC (corresponding author), Taipei Med Univ, TMU Res Ctr Urol & Kidney, Taipei 110, Taiwan.; Fang, TC (corresponding author), Taipei Med Univ, Coll Med, Grad Inst Clin Med, Taipei 110, Taiwan.; Fang, TC (corresponding author), Taipei Med Univ, Taipei Med Univ Hosp, Dept Internal Med, Div Nephrol, Taipei 110, Taiwan.
EM fangtechao@gmail.com
RI Fang, Te-Chao/V-7731-2017
OI Fang, Te-Chao/0000-0002-5577-9280; Chou, Chu-Lin/0000-0002-9695-1067
FU Taipei Medical University [DP2-111-21121-01-O-07-02]; TaipeiMedical
   University Hospital, TaipeiMedical University [110TMU-TMUH-17]
FX This study was financed by grant DP2-111-21121-01-O-07-02 and
   110TMU-TMUH-17 from Taipei Medical University, and TaipeiMedical
   University Hospital, TaipeiMedical University, respectively.
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NR 55
TC 1
Z9 1
U1 0
U2 4
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD SEP
PY 2022
VL 14
IS 18
AR 3759
DI 10.3390/nu14183759
PG 13
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 4R6AW
UT WOS:000856845400001
PM 36145135
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Lee, JH
   Ju, HJ
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   Almurayshid, A
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   Ezzedine, K
   Bae, JM
AF Lee, Ji Hae
   Ju, Hyun Jeong
   Seo, Ji Min
   Almurayshid, Abdurrahman
   Kim, Gyong Moon
   Ezzedine, Khaled
   Bae, Jung Min
TI Comorbidities in Patients with Vitiligo: A Systematic Review and
   Meta-Analysis
SO JOURNAL OF INVESTIGATIVE DERMATOLOGY
LA English
DT Review
ID INFLAMMATORY-BOWEL-DISEASE; AUTOIMMUNE-DISEASES; THYROID-DYSFUNCTION;
   INCREASED RISK; CIRCULATING AUTOANTIBODIES; AUDIOLOGICAL ABNORMALITIES;
   METABOLIC SYNDROME; ATOPIC-DERMATITIS; OXIDATIVE STRESS; ALOPECIA-AREATA
AB Vitiligo has been reported to be associated with a variety of diseases, but it has not been systematically reviewed. Therefore, we aimed to identify prevalent diseases in patients with vitiligo and quantify their associations compared with those in healthy controls. A comprehensive search of MEDLINE and EMBASE from the inception to June 2022 was conducted. Observational studies on prevalent diseases in patients with vitiligo compared with those in healthy controls were included, whereas studies limited to pediatrics or providing only laboratory results were excluded. A total of 78 studies were eligible for analyses. Patients with vitiligo showed higher risks of having comorbid autoimmune and connective tissue diseases, including alopecia areata (OR = 2.63, 95% confidence interval [CI] = 2.50.2.78), discoid lupus erythematosus (OR = 2.54, 95% CI = 1.74.3.72), Sjogren's syndrome (OR = 2.50, 95% CI = 1.98.3.16), myasthenia gravis (OR = 2.30, 95% CI = 1.74.3.02), systemic lupus erythematosus (OR = 1.96, 95% CI = 1.52.2.52), and rheumatoid arthritis (OR = 1.82, 95% CI = 1.55.2.15). Thyroid diseases, diabetes mellitus, metabolic syndrome, sensorineural hypoacusis, and ophthalmic abnormalities were also more prevalent in patients with vitiligo. In conclusion, vitiligo is associated with various systemic diseases. Physicians should evaluate and manage potential comorbid conditions in patients with vitiligo.
C1 [Lee, Ji Hae; Ju, Hyun Jeong; Kim, Gyong Moon; Bae, Jung Min] Catholic Univ Korea, St Vincents Hosp, Coll Med, Dept Dermatol, 93 Jungbu Daero, Suwon 16247, South Korea.
   [Seo, Ji Min] Catholic Univ Korea, Uijeongbu St Marys Hosp, Coll Med, Dept Dermatol, Uijongbu, South Korea.
   [Almurayshid, Abdurrahman] Prince Sattam Bin Abdulaziz Univ, Dept Med, Coll Med, Al Kharj City, Saudi Arabia.
   [Ezzedine, Khaled] Paris Est Creteil Univ, Henry Mondor Hosp, Dept Dermatol, Creteil, France.
C3 Catholic University of Korea; Catholic University of Korea; Prince
   Sattam Bin Abdulaziz University; Assistance Publique Hopitaux Paris
   (APHP); Universite Paris-Est-Creteil-Val-de-Marne (UPEC); Hopital
   Universitaire Henri-Mondor - APHP
RP Bae, JM (corresponding author), Catholic Univ Korea, St Vincents Hosp, Coll Med, Dept Dermatol, 93 Jungbu Daero, Suwon 16247, South Korea.
EM jminbae@gmail.com
RI Lee, Solam/ABE-9674-2021; Almurayshid, Abdurrahman/O-3501-2018
OI Bae, Jung Min/0000-0001-5975-8519; Almurayshid,
   Abdurrahman/0000-0002-1499-6801; Lee, Ji hae/0000-0002-5132-1627; SEO,
   JI MIN/0000-0003-0289-5971; Ju, Hyun Jeong/0000-0003-2711-3112
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NR 102
TC 29
Z9 30
U1 0
U2 6
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0022-202X
EI 1523-1747
J9 J INVEST DERMATOL
JI J. Invest. Dermatol.
PD MAY
PY 2023
VL 143
IS 5
BP 777
EP +
DI 10.1016/j.jid.2022.10.021
EA APR 2023
PG 19
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA GY6I3
UT WOS:001156271100001
PM 36574529
OA Bronze
DA 2025-06-11
ER

PT J
AU Poulsen, NB
   Lambert, MNT
   Jeppesen, PB
AF Poulsen, Nikolaj Bech
   Lambert, Max Norman Tandrup
   Jeppesen, Per Bendix
TI The Effect of Plant Derived Bioactive Compounds on Inflammation: A
   Systematic Review and Meta-Analysis
SO MOLECULAR NUTRITION & FOOD RESEARCH
LA English
DT Review; Early Access
DE CRP; inflammation; phytochemicals; vegetable and fruit
ID C-REACTIVE PROTEIN; RANDOMIZED DOUBLE-BLIND; CARDIOVASCULAR
   RISK-FACTORS; MEDITERRANEAN-STYLE DIET; HYPERTENSION EATING PLAN;
   METABOLIC SYNDROME; OXIDATIVE STRESS; FLAXSEED OIL; OLIVE OIL; VASCULAR
   INFLAMMATION
AB A growing number of people worldwide are changing their lifestyle leading to an increasing number of overweight and obese individuals with metabolic syndrome (MetS). With obesity and MetS come an elevated inflammatory state resulting in increased risk of Type 2 diabetes, cardiovascular disease, among other lifestyle diseases. Fruits and vegetables (FV) contain phytochemicals with health beneficial effects including anti-oxidative and anti-inflammatory properties. This systematic review and meta-analysis aims to investigate the effects of diets high in FV, and plant-based products on C-reactive protein (CRP). A systematic search in PUBMED and EMBASE gave rise to 883 articles, 16 of which are included in the meta-analysis. The effects of plant-based products and diets are investigated in subgroups including overweight, obese, and diabetes; as wells as the effect of plant-oils and anthocyanin on CRP. The analysis shows an overall significant reduction in CRP for all articles (p= 0.0006). A significant decrease in diabetic (p= 0.01), overweight (p= 0.005), and obese patients (p= 0.05) is observed, including significant effects of anthocyanins (p= 0.001) and plant-oils (p< 0.00001) on CRP. These findings strongly support the recommendation for diets high in FV and plant-oils to help attenuate elevated CRP.
C1 [Poulsen, Nikolaj Bech; Lambert, Max Norman Tandrup; Jeppesen, Per Bendix] Aarhus Univ, Aarhus Univ Hosp, Dept Clin Med, Palle Juul Jensens Blvd 165, DK-8200 Aarhus N, Denmark.
C3 Aarhus University
RP Jeppesen, PB (corresponding author), Aarhus Univ, Aarhus Univ Hosp, Dept Clin Med, Palle Juul Jensens Blvd 165, DK-8200 Aarhus N, Denmark.
EM per.bendix.jeppesen@clin.au.dk
OI Jeppesen, Per Bendix/0000-0001-8042-7554
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NR 94
TC 34
Z9 35
U1 0
U2 32
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1613-4125
EI 1613-4133
J9 MOL NUTR FOOD RES
JI Mol. Nutr. Food Res.
PD 2020 AUG 19
PY 2020
AR 2000473
DI 10.1002/mnfr.202000473
EA AUG 2020
PG 14
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA ND4DB
UT WOS:000561851200001
PM 32761736
DA 2025-06-11
ER

PT J
AU Díaz-Aguila, Y
   Castelán, F
   Cuevas, E
   Zambrano, E
   Martínez-Gómez, M
   Muñoz, A
   Rodríguez-Antolín, J
   Nicolás-Toledo, L
AF Diaz-Aguila, Yadira
   Castelan, Francisco
   Cuevas, Estela
   Zambrano, Elena
   Martinez-Gomez, Margarita
   Munoz, Alvaro
   Rodriguez-Antolin, Jorge
   Nicolas-Toledo, Leticia
TI Consumption of sucrose from infancy increases the visceral fat
   accumulation, concentration of triglycerides, insulin and leptin, and
   generates abnormalities in the adrenal gland
SO ANATOMICAL SCIENCE INTERNATIONAL
LA English
DT Article
DE Visceral fat; Triglycerides; Insulin; Leptin; Adrenal gland
ID CHRONIC STRESS; SERUM LEPTIN; BODY-WEIGHT; SHORT-TERM; DIET; CHILDREN;
   GLUCOSE; ENERGY; GENOTOXICITY; SUPPRESSION
AB Consumption of sugar-sweetened beverages promotes the development of metabolic syndrome (MetS) and type 2 diabetes mellitus in humans. One factor related to the appearance of MetS components is the dysfunction of the adrenal gland. In fact, the experimental generation of hyperglycemia has been associated with morphological and microvascular changes in the adrenal glands of rats. We hypothesized that high sucrose consumption from infancy promotes histological disruption of the adrenal glands associated with the appearance of metabolic syndrome indicators. Male Wistar rats were separated at weaning (21 days old) into two groups: free access to tap water (control group, C) or 30 % sucrose diluted in water (sugar-fed group). After 12 weeks, high sucrose consumption promoted an increase in visceral fat accumulation, adipose cell number, and insulin resistance. Also, a rise in the concentration of triglycerides, very low-density lipoprotein, insulin and leptin was observed. In control rats, a histomorphometric asymmetry between the right and left adrenal glands was found. In the sugar-fed group, sucrose consumption produced a major change in adrenal gland asymmetry. No changes in corticosterone serum level were observed in either group. Our results suggest that a high sucrose liquid-diet from early life alters the morphology of adrenocortical zones, leading to MetS indicators.
C1 [Diaz-Aguila, Yadira] Univ Autonoma Tlaxcala, Ciencias Biol, Tlaxcala, Mexico.
   [Castelan, Francisco; Cuevas, Estela; Martinez-Gomez, Margarita; Rodriguez-Antolin, Jorge; Nicolas-Toledo, Leticia] Univ Autonoma Tlaxcala, Ctr Tlaxcala Biol Conducta, Tlaxcala, Mexico.
   [Zambrano, Elena] Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Biol Reprod, Mexico City, DF, Mexico.
   [Martinez-Gomez, Margarita] Univ Nacl Autonoma Mexico, Inst Invest Biomed, Dept Biol Celular & Fisiol, Mexico City 04510, DF, Mexico.
   [Munoz, Alvaro] Houston Methodist Res Inst, Houston, TX USA.
C3 Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran -
   Mexico; Universidad Nacional Autonoma de Mexico; Houston Methodist
RP Nicolás-Toledo, L (corresponding author), Univ Autonoma Tlaxcala, Ctr Tlaxcala Biol Conducta, Tlaxcala, Mexico.
EM lettita2@yahoo.com
RI Rodríguez-Antolín, Jorge/HZH-9026-2023; Castelan,
   Francisco/AFU-8435-2022; Martinez, Margarita/KFR-3842-2024; Estela,
   Cuevas-Romero/H-7856-2019; Munoz, Alvaro/AAD-3972-2021; Nicolás-Toledo,
   Leticia/AAA-4587-2022; Munoz, Alvaro/P-6089-2017
OI Zambrano, Elena/0000-0002-0362-9117; Rodriguez-Antolin,
   Jorge/0000-0003-3971-437X; Martinez-Gomez,
   Margarita/0000-0002-3534-1265; Castelan, Francisco/0000-0002-9835-3335;
   Cuevas-Romero, Estela/0000-0003-3960-2351; Munoz,
   Alvaro/0000-0002-5726-0810
FU Consejo Nacional de Ciencia y Tecnologia [366801]; PNPC [C-122/2014,
   225126]
FX This study was supported by the Consejo Nacional de Ciencia y Tecnologia
   through a pre-doctoral fellowship (Reg. 366801) to Y.D., PNPC
   C-122/2014, 225126 Apoyo de Infraestructura al Cuerpo Academico
   Fisiologia del Comportamiento, UATx). We would like to thank Laura
   Garcia for technical assistance.
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NR 49
TC 12
Z9 13
U1 0
U2 15
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1447-6959
EI 1447-073X
J9 ANAT SCI INT
JI Anat. Sci. Int.
PD MAR
PY 2016
VL 91
IS 2
BP 151
EP 162
DI 10.1007/s12565-015-0279-9
PG 12
WC Anatomy & Morphology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Anatomy & Morphology
GA DD7BH
UT WOS:000370078200004
PM 25834995
DA 2025-06-11
ER

PT J
AU Baudoin, L
   Issad, T
AF Baudoin, Lea
   Issad, Tarik
TI O-GlcNAcylation and inflammation: a vast territory to explore
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Review
DE O-GlcNAc glycosylation; diabetes; metabolic syndrome; inflammation;
   cytokines; macrophages; nitric oxide; NF kappa B
ID NF-KAPPA-B; INDUCED INSULIN-RESISTANCE; PROTEIN-KINASE-C;
   GLUCOSE-INDUCED EXPRESSION; NITRIC-OXIDE SYNTHASE; HEXOSAMINE PATHWAY;
   TRANSCRIPTIONAL ACTIVITY; GLCNAC MODIFICATION; MONONUCLEAR-CELLS;
   INDUCED ACTIVATION
AB O-GlcNAcylation is a reversible post-translational modification that regulates the activities of cytosolic and nuclear proteins according to glucose availability. This modification appears to participate in several hyperglycemia-associated complications. An important feature of metabolic diseases such as diabetes and obesity is the presence of a low-grade chronic inflammation that causes numerous complications. Hyperglycemia associated with the metabolic syndrome is known to promote inflammatory processes through different mechanisms including oxidative stress and abnormally elevated protein O-GlcNAcylation. However, the role of O-GlcNAcylation on inflammation remains contradictory. O-GlcNAcylation associated with hyperglycemia has been shown to increase nuclear factor kappa B (NF kappa B) transcriptional activity through different mechanisms.This could contribute in inflammation associated diabetic complications. However, in other conditions such as acute vascular injury, O-linked N-acetyl glucosamine (O-GlcNAc) also exerts anti-inflammatory effects via inhibition of the NF kappa B pathway, suggesting a complex regulation of inflammation by O-GlcNAc. Moreover, whereas macrophages and monocytes exposed to high glucose for a long-term period developed a pro-inflammatory phenotype, the impact of O-GlcNAcylation in these cells remains unclear. A future challenge will be to clearly establish the role of O-GlcNAcylation in pro- and anti-inflammatory functions in macrophages.
C1 [Baudoin, Lea; Issad, Tarik] Univ Paris 05, Inst Cochin, CNRS, UMR8104, Paris, France.
   [Baudoin, Lea; Issad, Tarik] INSERM, U1016, Paris, France.
C3 Centre National de la Recherche Scientifique (CNRS); CNRS - National
   Institute for Biology (INSB); Institut National de la Sante et de la
   Recherche Medicale (Inserm); Universite Paris Cite; Institut National de
   la Sante et de la Recherche Medicale (Inserm); Universite Paris Cite
RP Issad, T (corresponding author), Inst Cochin, Dept Endocrinol Metab & Diabet, 22 Rue Mechain, F-75014 Paris, France.
EM tarik.issad@inserm.fr
OI Issad, Tarik/0000-0002-2638-6330
FU CORDDIM-Ile de France; Societe Francophone du Diabete-Antadir
FX Lea Baudoin holds a Ph.D. fellowship from the CORDDIM-Ile de France. Our
   work is performed within the Departement Hospitalo-Universitaire (DHU)
   AUToimmune and HORmonal diseaseS and is supported by a grant from the
   Societe Francophone du Diabete-Antadir (2013).
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NR 83
TC 65
Z9 73
U1 1
U2 11
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD JAN 9
PY 2015
VL 5
AR 235
DI 10.3389/fendo.2016.00235
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA DP3HR
UT WOS:000378384400002
PM 25620956
DA 2025-06-11
ER

PT J
AU Litwin, M
   Michalkiewicz, J
   Niemirska, A
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AF Litwin, Mieczyslaw
   Michalkiewicz, Jacek
   Niemirska, Anna
   Gockowska, Lidia
   Kubiszewska, Izabela
   Wierzbicka, Aldona
   Wawer, Zbigniew T.
   Janas, Roman
TI Inflammatory activation in children with primary hypertension
SO PEDIATRIC NEPHROLOGY
LA English
DT Article
DE Atherosclerosis; Primary hypertension; Children; Inflammation;
   Cytokines; Chemokines; Target organ damage
ID C-REACTIVE PROTEIN; LEFT-VENTRICULAR HYPERTROPHY; INTIMA-MEDIA
   THICKNESS; METABOLIC SYNDROME; ADOLESCENTS; CHEMOKINES; DISEASE
AB Low-grade inflammation plays a role in the pathogenesis of primary hypertension (PH) and target organ damage (TOD). We evaluated the profile of inflammatory mediators (CRP, RANTES, MIP-1 beta, MIP-1 alpha, MCP-1, IL-6, angiogenin, adiponectin) in 30 healthy children (12.7 +/- 3.3 years) and 44 patients with untreated PH (13.7 +/- 2.7 years; n.s). Patients had greater concentrations of CRP, MIP-1 beta, and RANTES than controls (all p < 0.05). Children with metabolic syndrome (MS) had greater CRP than children without MS (p = 0.007) and CRP correlated with number of MS criteria, body mass index (BMI), visceral fat, deep subcutaneous fat assessed by magnetic resonance imaging, carotid intima-media thickness (cIMT), left ventricular mass index, and markers of oxidative stress. RANTES correlated with cholesterol, LDL cholesterol, ApoB, and ApoB/ApoA1. Angiogenin correlated with BMI, waist circumference, visceral fat, uric acid, and patients with cIMT > 2SD had greater concentration of angiogenin than those with normal cIMT (p = 0.03). Adiponectin was lower in patients with cIMT > 2SD than in those with normal cIMT (p = 0.02). No model explaining variability of TOD has been built. Elevated RANTES and MIP-1 beta and normal IL-6 and TNF-alpha levels indicate a vascular inflammatory process. Lack of correlation between CRP and chemokines suggests that vascular inflammation in PH precedes the systemic inflammatory changes.
C1 [Litwin, Mieczyslaw] Childrens Mem Hlth Inst, Dept Res, Warsaw, Poland.
   [Litwin, Mieczyslaw; Niemirska, Anna] Childrens Mem Hlth Inst, Dept Nephrol & Arterial Hypertens, Warsaw, Poland.
   [Michalkiewicz, Jacek] Childrens Mem Hlth Inst, Dept Microbiol & Immunol, Warsaw, Poland.
   [Michalkiewicz, Jacek; Gockowska, Lidia; Kubiszewska, Izabela] Nicholas Copernicus Univ, Coll Med, Dept Immunol, Bydgoszcz, Poland.
   [Wierzbicka, Aldona; Wawer, Zbigniew T.] Childrens Mem Hlth Inst, Dept Biochem & Expt Med, Warsaw, Poland.
   [Janas, Roman] Childrens Mem Hlth Inst, Dept Radioimmunol, Warsaw, Poland.
C3 Children's Memorial Health Institute; Children's Memorial Health
   Institute; Children's Memorial Health Institute; Nicolaus Copernicus
   University; Ludwik Rydygier Collegium Medicum; Children's Memorial
   Health Institute; Children's Memorial Health Institute
RP Litwin, M (corresponding author), Childrens Mem Hlth Inst, Dept Res, Warsaw, Poland.
EM m.litwin@czd.pl
RI Michałkiewicz, Jacek/I-1135-2014; Gackowska, Lidia/G-8885-2014; Litwin,
   Mieczyslaw/L-4648-2017; Kubiszewska, Izabela/G-8930-2014; Niemirska,
   Anna/W-2780-2018
OI Gackowska, Lidia/0000-0001-7666-504X; Wawer,
   Zbigniew/0000-0002-8866-4578; Litwin, Mieczyslaw/0000-0002-5241-2483;
   Michalkiewicz, Jacek/0000-0001-7773-1766; Kubiszewska,
   Izabela/0000-0003-4224-0961; Wierzbicka-Rucinska,
   Aldona/0000-0002-9578-8894; Niemirska, Anna/0000-0003-4546-5541; Janas,
   Roman/0000-0003-2853-9676
FU Ministry of Science and Higher Education [NN40710855134]
FX The study was supported by grant of Ministry of Science and Higher
   Education NN40710855134.
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NR 22
TC 41
Z9 43
U1 0
U2 12
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0931-041X
EI 1432-198X
J9 PEDIATR NEPHROL
JI Pediatr. Nephrol.
PD SEP
PY 2010
VL 25
IS 9
BP 1711
EP 1718
DI 10.1007/s00467-010-1548-4
PG 8
WC Pediatrics; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics; Urology & Nephrology
GA 630BU
UT WOS:000280247200015
PM 20495830
DA 2025-06-11
ER

PT J
AU Lustig, RH
AF Lustig, Robert H.
TI Fructose: Metabolic, Hedonic, and Societal Parallels with Ethanol
SO JOURNAL OF THE AMERICAN DIETETIC ASSOCIATION
LA English
DT Review
ID DE-NOVO LIPOGENESIS; HEPATIC INSULIN-RESISTANCE; FATTY LIVER-DISEASE;
   SUGAR-SWEETENED BEVERAGES; TRIGLYCERIDE TRANSFER PROTEIN;
   ENDOPLASMIC-RETICULUM STRESS; SOFT DRINK CONSUMPTION;
   CORONARY-HEART-DISEASE; N-TERMINAL KINASE; DIETARY FRUCTOSE
AB Rates of fructose consumption continue to rise nationwide and have been linked to rising rates of obesity, type 2 diabetes, and metabolic syndrome. Because obesity has been equated with addiction, and because of their evolutionary commonalities, we chose to examine the metabolic, hedonic, and societal similarities between fructose and its fermentation byproduct ethanol Elucidation of fructose metabolism in liver and fructose action in brain demonstrate three parallelisms with ethanol First, hepatic fructose metabolism is similar to ethanol, as they both serve as substrates for de novo hpogenesis, and in the process both promote hepatic insulin resistance, dyslipidemia, and hepatic steatosis. Second, fructosylation of proteins with resultant superoxide formation can result in hepatic inflammation similar to acetaldehyde, an intermediary metabolite of ethanol. Lastly, by stimulating the "hedonic pathway" of the brain both directly and indirectly, fructose creates habituation, and possibly dependence; also paralleling ethanol. Thus, fructose induces alterations in both hepatic metabolism and central nervous system energy signaling, leading to a "vicious cycle" of excessive consumption and disease consistent with metabolic syndrome. On a societal level, the treatment of fructose as a commodity exhibits market similarities to ethanol. Analogous to ethanol, societal efforts to reduce fructose consumption will likely be necessary to combat the obesity epidemic. J Am Diet Assoc 2010,110 1307-1321
C1 [Lustig, Robert H.] Univ Calif San Francisco, Div Endocrinol, San Francisco, CA 94143 USA.
C3 University of California System; University of California San Francisco
RP Lustig, RH (corresponding author), Univ Calif San Francisco, Div Pediat Endocrinol, Box 0434,Room S-679,513 Parnassus Ave, San Francisco, CA 94143 USA.
RI Lustig, Robert/O-9380-2019
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NR 192
TC 222
Z9 242
U1 1
U2 76
PU AMER DIETETIC ASSOC
PI CHICAGO
PA 120 S RIVERSIDE PLZ, STE 2000, CHICAGO, IL 60606-6995 USA
SN 0002-8223
J9 J AM DIET ASSOC
JI J. Am. Diet. Assoc.
PD SEP
PY 2010
VL 110
IS 9
BP 1307
EP 1321
DI 10.1016/j.jada.2010.06.008
PG 15
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 645YG
UT WOS:000281501500008
PM 20800122
DA 2025-06-11
ER

PT J
AU Longo, KA
   Charoenthongtrakul, S
   Giuliana, DJ
   Govek, EK
   McDonagh, T
   Qi, Y
   DiStefano, PS
   Geddes, BJ
AF Longo, Kenneth A.
   Charoenthongtrakul, Soratree
   Giuliana, Derek J.
   Govek, Elizabeth K.
   McDonagh, Thomas
   Qi, Yong
   DiStefano, Peter S.
   Geddes, Brad J.
TI Improved insulin sensitivity and metabolic flexibility in ghrelin
   receptor knockout mice
SO REGULATORY PEPTIDES
LA English
DT Article
DE Ghrelin; Receptor; Metabolic syndrome; Diabetes; Insulin sensitivity;
   Metabolic flexibility
ID MONOCYTE CHEMOATTRACTANT PROTEIN-1; HEPATIC STEATOSIS; RESISTANCE;
   OBESITY
AB Stimulation of the ghrelin receptor (GhrR) by ghrelin results in a variety of metabolic changes including increased food intake, fat storage and insulin resistance. Loss of ghrelin signaling is protective against diet-induced obesity, suggesting that ghrelin plays a significant homeostatic role in conditions of metabolic stress. We examined glycemic control in GhrR -/- mice fed a high-fat diet, and used indirect calorimetry to assess fuel substrate usage and energy expenditure. GhrR -/- mice fed a high-fat diet had several measures of greater insulin sensitivity, including: lower fasted blood glucose and plasma insulin, lower %Hb(A1c), lower insulin levels during glucose tolerance tests, and improved performance in hyperinsulinemic-euglycemic and hyperglycemic clamp studies. GhrR -/- mice fed a high-fat diet did not develop hepatic steatosis and had lower total cholesterol, relative to controls. Furthermore, GhrR -/- mice demonstrated a lower intestinal triglyceride secretion rate of dietary lipid. GhrR -/- mice have higher respiratory quotients (RQ), indicating a preference for carbohydrate as fuel. The range of RQ values was wider in GhrR -/- mice, indicating greater metabolic flexibility and insulin sensitivity in these animals. We therefore propose that loss of ghrelin signaling promotes insulin sensitivity and metabolic flexibility, and protects against several fatty diet-induced features of metabolic syndrome due to convergent changes in the intake, absorption and utilization of energy. (C) 2008 Elsevier B.V. All rights reserved.
C1 [Longo, Kenneth A.; Charoenthongtrakul, Soratree; Giuliana, Derek J.; Govek, Elizabeth K.; McDonagh, Thomas; Qi, Yong; DiStefano, Peter S.; Geddes, Brad J.] Elixir Pharmaceut Inc, Cambridge, MA 02139 USA.
RP Longo, KA (corresponding author), Elixir Pharmaceut Inc, 12 Emily St, Cambridge, MA 02139 USA.
EM klongo@elixirpharm.com
RI Longo, Kenneth/A-5631-2010
OI Giuliana, Derek/0000-0002-1536-4080
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PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0167-0115
EI 1873-1686
J9 REGUL PEPTIDES
JI Regul. Pept.
PD OCT 9
PY 2008
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IS 1-3
BP 55
EP 61
DI 10.1016/j.regpep.2008.03.011
PG 7
WC Endocrinology & Metabolism; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Physiology
GA 361KK
UT WOS:000260126300010
PM 18453014
DA 2025-06-11
ER

PT J
AU Hu, SCS
   Lan, CCE
AF Hu, Stephen Chu-Sung
   Lan, Cheng-Che E.
TI Psoriasis and Cardiovascular Comorbidities: Focusing on Severe Vascular
   Events, Cardiovascular Risk Factors and Implications for Treatment
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE psoriasis; cardiovascular disease; cerebrovascular disease;
   atherosclerosis; hypertension; diabetes mellitus; obesity; dyslipidemia;
   metabolic syndrome; systemic inflammation
ID MYOCARDIAL-INFARCTION RISK; CHRONIC PLAQUE PSORIASIS; FACTOR INHIBITOR
   THERAPY; C-REACTIVE PROTEIN; LONG-TERM SAFETY; PLATELET-DERIVED
   MICROPARTICLES; CORONARY-ARTERY-DISEASE; LIFE-STYLE INTERVENTION;
   FACTOR-ALPHA INHIBITORS; SYSTEMIC ANTIINFLAMMATORY DRUGS
AB Psoriasis is a common and chronic inflammatory disease of the skin. It may impair the physical and psychosocial function of patients and lead to decreased quality of life. Traditionally, psoriasis has been regarded as a disease affecting only the skin and joints. More recently, studies have shown that psoriasis is a systemic inflammatory disorder which can be associated with various comorbidities. In particular, psoriasis is associated with an increased risk of developing severe vascular events such as myocardial infarction and stroke. In addition, the prevalence rates of cardiovascular risk factors are increased, including hypertension, diabetes mellitus, dyslipidemia, obesity, and metabolic syndrome. Consequently, mortality rates have been found to be increased and life expectancy decreased in patients with psoriasis, as compared to the general population. Various studies have also shown that systemic treatments for psoriasis, including methotrexate and tumor necrosis factor-alpha inhibitors, may significantly decrease cardiovascular risk. Mechanistically, the presence of common inflammatory pathways, secretion of adipokines, insulin resistance, angiogenesis, oxidative stress, microparticles, and hypercoagulability may explain the association between psoriasis and cardiometabolic disorders. In this article, we review the evidence regarding the association between psoriasis and cardiovascular comorbidities, focusing on severe vascular events, cardiovascular risk factors and implications for treatment.
C1 [Hu, Stephen Chu-Sung; Lan, Cheng-Che E.] Kaohsiung Med Univ, Dept Dermatol, Coll Med, Kaohsiung 807, Taiwan.
   [Hu, Stephen Chu-Sung; Lan, Cheng-Che E.] Kaohsiung Med Univ Hosp, Dept Dermatol, Kaohsiung 807, Taiwan.
C3 Kaohsiung Medical University; Kaohsiung Medical University; Kaohsiung
   Medical University Hospital
RP Lan, CCE (corresponding author), Kaohsiung Med Univ, Dept Dermatol, Coll Med, Kaohsiung 807, Taiwan.; Lan, CCE (corresponding author), Kaohsiung Med Univ Hosp, Dept Dermatol, Kaohsiung 807, Taiwan.
EM stephenhu30@hotmail.com; laneric@cc.kmu.edu.tw
RI Wang, Chi-Huei/C-9655-2009
OI Hu, Stephen Chu-Sung/0000-0002-1832-4471
FU Ministry of Science and Technology, Taiwan [104-2314-B-037-048-MY3,
   105-2628-B-037-008-MY2]; Kaohsiung Medical University Hospital
   [KMUH104-4R49, KMUH105-5R51]; Kaohsiung Medical University
   [KMU-TP105C09]
FX This work was supported by grants from the Ministry of Science and
   Technology, Taiwan (104-2314-B-037-048-MY3, 105-2628-B-037-008-MY2),
   Kaohsiung Medical University Hospital (KMUH104-4R49, KMUH105-5R51), and
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NR 303
TC 139
Z9 147
U1 2
U2 17
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD OCT
PY 2017
VL 18
IS 10
AR 2211
DI 10.3390/ijms18102211
PG 34
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA FM0QL
UT WOS:000414671800193
PM 29065479
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Mollbrink, A
   Jawad, R
   Vlamis-Gardikas, A
   Edenvik, P
   Isaksson, B
   Danielsson, O
   Stål, P
   Fernandes, AP
AF Mollbrink, A.
   Jawad, R.
   Vlamis-Gardikas, A.
   Edenvik, P.
   Isaksson, B.
   Danielsson, O.
   Stal, P.
   Fernandes, A. P.
TI EXPRESSION OF THIOREDOXINS AND GLUTAREDOXINS IN HUMAN HEPATOCELLULAR
   CARCINOMA: CORRELATION TO CELL PROLIFERATION, TUMOR SIZE AND METABOLIC
   SYNDROME
SO INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY
LA English
DT Article
DE hepatocellular carcinoma; thioredoxin; glutaredoxin;
   immunohistochemistty
ID OXIDATIVE STRESS; POOR-PROGNOSIS; CANCER; PROTEIN; SENSITIVITY; DISEASE;
   GROWTH; INCREASES; CISPLATIN; ENZYMES
AB Thioredoxins (Trx) and glutaredoxins (Grx) are thiol oxidoreductases that are ubiquitously expressed, and are involved in several biological processes. The expression of thioredoxins and glutaredoxins is induced in many neoplasms, and correlates with prognosis in gallbladder and colorectal carcinoma. The aim of the present study was to examine the expression pattern of these proteins (redoxins) in hepatocellular carcinoma (HCC) and to correlate their levels with clinical features. Paraffin-embedded tissues from 25 patients resected for HCC and 15 patients resected for colorectal carcinoma (CRC) liver metastases were analyzed with immunohistochemistry. Our results showed that Trx1, Trx2 and Grx5 were upregulated in HCCs as compared to the respective surrounding liver. In comparison, almost all redoxins were upregulated in CRC liver metastases, with Trxl and Grx3 being significantly more increased in the CRC liver metastases than in the primary HCC tumors. In HCC, Trxl correlated significantly with cell proliferation, and with a trend towards increased levels with micro-vascular invasion, while expression of Trx2 decreased with tumor size. Trxl levels were lower in tumors of males, smokers, and patients with high alcohol consumption. Grx2 levels were significantly higher in patients with metabolic syndrome. In conclusion, this study illustrates specific correlations of individual redoxins to clinical features of HCC, and implicates the redoxins in the pathogenesis of HCC.
C1 [Mollbrink, A.; Edenvik, P.; Isaksson, B.; Stal, P.] Karolinska Univ, Huddinge Hosp, Karolinska Inst, Div Gastroenterol & Hepatol,Dept Med, Stockholm, Sweden.
   [Mollbrink, A.; Jawad, R.; Danielsson, O.; Fernandes, A. P.] Karolinska Univ, Huddinge Hosp, Karolinska Inst, Div Pathol,Dept Lab Med, Stockholm, Sweden.
   [Vlamis-Gardikas, A.] Univ Patras, Dept Chem, Rion, Greece.
C3 Karolinska Institutet; Karolinska University Hospital; Karolinska
   Institutet; Karolinska University Hospital; University of Patras
RP Fernandes, AP (corresponding author), Karolinska Inst, Div Biochem, Dept Med Biochem & Biophys MBB, SE-17177 Stockholm, Sweden.
EM aristi.fernandes@ki.se
RI Danielsson, Olof/MGA-0381-2025; Stål, Per/J-2154-2019; Fernandes,
   Aristi/D-2507-2015; Vlamis, Alexios/AAF-5152-2020
OI Fernandes, Aristi/0000-0002-4145-0222; Stal, Per/0000-0003-2915-1964;
   Vlamis, Alexios/0000-0001-5068-6459; Jawad, Rim/0000-0002-4216-0913
FU Bengt Ihre's foundation; Swedish Cancer Society (Cancerfonden); Cancer
   and Allergy foundation (Cancer och Allergifonden)
FX This study was supported by grants from Bengt Ihre's foundation, the
   Swedish Cancer Society (Cancerfonden) and the Cancer and Allergy
   foundation (Cancer och Allergifonden). We are grateful to Carsten
   Berndt, Heinrich-Heine Universitat, Dusseldorf, Germany, for the kind
   gift of the overexpression plasmid encoding Grx2, to Catrine Johansson
   from the Structural Genomics Consortium, Oxford, United Kingdom for the
   plasmids for the overexpression of Grx3 and Grx5, and to study nurse
   Bent Sunde, for excellent care of the patients, and blood and tissue
   sampling. The authors confirm that there are no conflicts of interest.
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NR 32
TC 34
Z9 36
U1 2
U2 6
PU BIOLIFE SAS
PI SILVA MARINA (TE)
PA VIA S STEFANO 39 BIS, 64029 SILVA MARINA (TE), ITALY
SN 0394-6320
J9 INT J IMMUNOPATH PH
JI Int. J. Immunopathol. Pharmacol.
PD APR-JUN
PY 2014
VL 27
IS 2
BP 169
EP 183
DI 10.1177/039463201402700204
PG 15
WC Immunology; Pathology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Pathology; Pharmacology & Pharmacy
GA AL1RT
UT WOS:000338904500004
PM 25004829
DA 2025-06-11
ER

PT J
AU Uziel, O
   Laish, I
   Bulcheniko, M
   Harif, Y
   Kochavi-Shalem, N
   Aharoni, M
   Braunstein, R
   Lahav, M
   Ben-Ari, Z
AF Uziel, Orit
   Laish, Ido
   Bulcheniko, Marina
   Harif, Yael
   Kochavi-Shalem, Naama
   Aharoni, Maya
   Braunstein, Rony
   Lahav, Meir
   Ben-Ari, Ziv
TI Telomere shortening in liver transplant recipients is not influenced by
   underlying disease or metabolic derangements
SO ANNALS OF TRANSPLANTATION
LA English
DT Article
DE telomeres; liver; transplant
ID CHRONIC HEPATITIS-C; RISK-FACTORS; OXIDATIVE STRESS; LENGTH; SENESCENCE;
   CELLS; EPIDEMIOLOGY; ASSOCIATION; PREVALENCE; DIAGNOSIS
AB Background: Telomeres are non-coding regions of DNA that cap the ends of chromosomes. Their length is considered a marker of human replicative senescence and premature aging. Given the high association of liver transplantation with the metabolic syndrome, we hypothesized that liver transplant recipients may exhibit premature and accelerated aging.
   Material/Methods: Telomere length in peripheral blood lymphocytes was measured by polymerase chain reaction in 62 consecutive liver-transplant recipients and 59 healthy control subjects aged 20-76 years. Clinical and laboratory parameters were collected from the medical files.
   Results: The liver transplant recipients were significantly older than the control subjects (p=0.012), with significantly higher rates of obesity (BMI >30 kg/m(2)), dyslipidemia, hypertension, diabetes, and fatty liver. Mean telomere length was significantly shorter in the transplant group (0.59 +/- 0.6 vs. 1.91 +/- 1.78 in the controls, p<0.0001). Within the transplant group, there was no significant association between mean telomere length and underlying liver disease or presence of the metabolic syndrome or its constituents. On multivariate analysis, telomere length was negatively associated with patient age (p=0.0001), male sex (p=0.04), acute rejection (p=0.005), and fatty liver (p=0.009), and was positively associated with time from transplantation (p=0.006).
   Conclusions: Liver transplantation is associated with shortened telomere length in peripheral blood lymphocytes, suggesting accelerated senescence.
C1 [Uziel, Orit; Bulcheniko, Marina; Kochavi-Shalem, Naama; Lahav, Meir] Felsentein Med Res Ctr, Petah Tiqwa, Israel.
   [Laish, Ido] Meir Med Ctr, Dept Gastroenterol, Kefar Sava, Israel.
   [Bulcheniko, Marina; Aharoni, Maya; Lahav, Meir] Dept Internal Med, Petah Tiqwa, Israel.
   [Bulcheniko, Marina; Harif, Yael; Aharoni, Maya; Lahav, Meir; Ben-Ari, Ziv] Tel Aviv Univ, Sackler Fac Med, IL-69978 Tel Aviv, Israel.
   [Harif, Yael; Ben-Ari, Ziv] Rabin Med Ctr, Liver Inst, Petah Tiqwa, Israel.
   [Braunstein, Rony] Biomed Res, Tel Aviv, Israel.
C3 Tel Aviv University; Tel Aviv University; Sackler Faculty of Medicine;
   Tel Aviv University; Sackler Faculty of Medicine; Rabin Medical Center
RP Ben-Ari, Z (corresponding author), Chaim Sheba Med Ctr, Liver Dis Ctr, IL-52621 Tel Hashomer, Israel.
EM ziv.ben-ari@sheba.health.gov.il
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NR 35
TC 10
Z9 10
U1 0
U2 3
PU INT SCIENTIFIC LITERATURE, INC
PI SMITHTOWN
PA 361 FOREST LANE, SMITHTOWN, NY 11787 USA
SN 1425-9524
J9 ANN TRANSPL
JI Ann. Transpl.
PD OCT 21
PY 2013
VL 18
BP 567
EP 575
PG 9
WC Surgery; Transplantation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery; Transplantation
GA 242KN
UT WOS:000326240000001
PM 24141383
DA 2025-06-11
ER

PT J
AU Eleazu, C
   Suleiman, JB
   Othman, ZA
   Zakaria, Z
   Nna, VU
   Hussain, NHN
   Mohamed, M
AF Eleazu, Chinedum
   Suleiman, Joseph Bagi
   Othman, Zaidatul Akmal
   Zakaria, Zaida
   Nna, Victor Udo
   Hussain, Nik Hazlina Nik
   Mohamed, Mahaneem
TI Bee bread attenuates high fat diet induced renal pathology in obese rats
   via modulation of oxidative stress, downregulation of NF-kB mediated
   inflammation and Bax signalling
SO ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
LA English
DT Article
DE Obesity; renal dysfunction; nutrition; oxidative stress; antioxidants
ID INTERLEUKIN-1 RECEPTOR-I; BIOCHEMICAL PARAMETERS; ANTIOXIDANT ACTIVITY;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; LIPID-METABOLISM; TNF-ALPHA;
   KIDNEY; EXTRACT; INJURY
AB Context: Global prevalence of obesity is increasing. Objective: To study the effect of bee bread (BB) on serum renal function parameters, oxidative stress, inflammatory and B-cell associated protein X (Bax) in the kidneys of high fat diet (HFD) obese rats. Methods: Thirty-six male Sprague Dawley rats were used. Control: received rat diet and water (1 mL/kg); HFD group: received HFD and water (1 mL/kg): bee bread (BB) preventive or orlistat preventive: received HFD and BB (0.5 g/kg) or HFD and orlistat (10 mg/kg); BB or orlistat treatment: received BB (0.5 g/kg) or orlistat (10 mg/kg). Results: HFD group had increased body weight, Body Mass Index, Lee Obesity Indices, kidney weights, malondialdehyde, inflammatory markers, Bax; decreased glutathione peroxidase, glutathione-S-transferase, superoxide dismutase, total antioxidant activity, no differences (p > .05) in food intakes, serum creatinine, sodium, potassium, chloride, catalase compared to control. Conclusion: BB modulated most of these parameters, as corroborated by histology.
C1 [Eleazu, Chinedum] Alex Ekwueme Fed Univ, Dept Chem Biochem & Mol Biol, Ndufu Alike, Ebonyi State, Nigeria.
   [Eleazu, Chinedum; Suleiman, Joseph Bagi; Othman, Zaidatul Akmal; Zakaria, Zaida; Nna, Victor Udo; Mohamed, Mahaneem] Univ Sains Malaysia, Sch Med Sci, Dept Physiol, Kubang Kerian, Kelantan, Malaysia.
   [Suleiman, Joseph Bagi] Akanu Ibiam Fed Polytech, Dept Sci Lab Technol, Unwana, Ebonyi State, Nigeria.
   [Othman, Zaidatul Akmal] Univ Sultan Zainal Abidin, Fac Med, Terengganu, Malaysia.
   [Nna, Victor Udo] Univ Calabar, Coll Med Sci, Fac Basic Med Sci, Dept Physiol, Calabar, Cross River Sta, Nigeria.
   [Hussain, Nik Hazlina Nik] Univ Sains Malaysia, Sch Med Sci, Womens Hlth Dev Unit, Kubang Kerian, Kelantan, Malaysia.
   [Mohamed, Mahaneem] Univ Sains Malaysia, Sch Med Sci, Unit Integrat Med, Kubang Kerian, Kelantan, Malaysia.
C3 Universiti Sains Malaysia; Universiti Sultan Zainal Abidin; University
   of Calabar; Universiti Sains Malaysia; Universiti Sains Malaysia
RP Mohamed, M (corresponding author), Univ Sains Malaysia, Sch Med Sci, Dept Physiol, Kubang Kerian, Kelantan, Malaysia.
EM mahaneem@usm.my
RI Eleazu, Chinedum/AAY-8306-2020; suleiman, joseph/Q-3559-2018; Othman,
   Zaidatul/ABA-8283-2021; ZAKARIA, ZAIDA/H-3951-2016; Nik Hussain, Nik
   Hazlina/G-5453-2015; Mohamed, Mahaneem/F-1159-2011; Nna,
   Victor/D-8197-2015
OI ZAKARIA, ZAIDA/0000-0002-4138-4747; Nik Hussain, Nik
   Hazlina/0000-0002-9476-062X; Mohamed, Mahaneem/0000-0001-9333-1957;
   Eleazu, Chinedum/0000-0002-1574-0445; Nna, Victor/0000-0001-7616-9468;
   Othman, Zaidatul Akmal/0000-0002-9442-8563
FU Universiti Sains Malaysia Research Grant [1001]
FX This study was supported by Universiti Sains Malaysia Research Grant
   (1001.PPSP.8012251).
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NR 72
TC 26
Z9 26
U1 0
U2 8
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1381-3455
EI 1744-4160
J9 ARCH PHYSIOL BIOCHEM
JI Arch. Physiol. Biochem.
PD JUL 4
PY 2022
VL 128
IS 4
BP 1088
EP 1104
DI 10.1080/13813455.2020.1752258
EA APR 2020
PG 17
WC Biochemistry & Molecular Biology; Biophysics; Endocrinology &
   Metabolism; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Endocrinology &
   Metabolism; Physiology
GA 3L5FL
UT WOS:000528357300001
PM 32319823
DA 2025-06-11
ER

PT J
AU Abdelrahman, BA
   El-Khatib, AS
   Attia, YM
AF Abdelrahman, Basma A.
   El-Khatib, Aiman S.
   Attia, Yasmeen M.
TI Insights into the role of vitamin D in targeting the culprits of
   non-alcoholic fatty liver disease
SO LIFE SCIENCES
LA English
DT Review
DE VDR; NAFLD; Intestinal microbiota and integrity; Autophagy; ER stress;
   Inflammasomes
ID PRIMARY BILIARY-CIRRHOSIS; D-RECEPTOR POLYMORPHISMS; OXIDATIVE STRESS; D
   DEFICIENCY; 1,25-DIHYDROXYVITAMIN D-3; ENDOPLASMIC-RETICULUM;
   DOWN-REGULATION; GUT MICROBIOTA; ER STRESS; AUTOPHAGY
AB Vitamin D (VD) is a secosteroid hormone that is renowned for its crucial role in phospho-calcium homeostasis upon binding to the nuclear vitamin D receptor (VDR). Over and above, the pleiotropic immunomodulatory, antiinflammatory, and metabolic roles VD plays in different disease settings started to surface in the past few decades. On the other hand, a growing body of evidence suggests a correlation between non-alcoholic fatty liver disease (NAFLD) and its progressive inflammatory form non-alcoholic steatohepatitis (NASH) with vitamin D deficiency (VDD) owing to the former's ingrained link with obesity and metabolic syndrome. Accordingly, a better understanding of the contribution of disrupted VDR signalling to NAFLD incidence and progression would provide further insights into its diagnosis, treatment modalities, and prognosis. This is especially significant as, hitherto, no drug for NAFLD has been approved. This review, therefore, sought to set forth the likely contribution of VDR signalling in NAFLD and how it might influence its multiple drivers.
C1 [Abdelrahman, Basma A.; Attia, Yasmeen M.] British Univ Egypt, Fac Pharm, Dept Pharmacol, Cairo, Egypt.
   [Abdelrahman, Basma A.; Attia, Yasmeen M.] British Univ Egypt, Fac Pharm, Ctr Drug Res & Dev CDRD, Cairo, Egypt.
   [El-Khatib, Aiman S.] Cairo Univ, Fac Pharm, Dept Pharmacol & Toxicol, Kasr El Aini St, Cairo 11562, Egypt.
C3 Egyptian Knowledge Bank (EKB); British University in Egypt; Egyptian
   Knowledge Bank (EKB); British University in Egypt; Egyptian Knowledge
   Bank (EKB); Cairo University
RP El-Khatib, AS (corresponding author), Cairo Univ, Fac Pharm, Dept Pharmacol & Toxicol, Kasr El Aini St, Cairo 11562, Egypt.
EM aiman.elkhatib@pharma.cu.edu.eg
OI Abdelrahman, Basma A./0000-0003-2657-3109; S. El-Khatib,
   Aiman/0000-0002-2074-8337
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TC 5
Z9 5
U1 1
U2 4
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0024-3205
EI 1879-0631
J9 LIFE SCI
JI Life Sci.
PD NOV 1
PY 2023
VL 332
AR 122124
DI 10.1016/j.lfs.2023.122124
EA SEP 2023
PG 11
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA U6XG3
UT WOS:001086209600001
PM 37742738
DA 2025-06-11
ER

PT J
AU D'Angelo, C
   Franceschelli, S
   Quiles, JL
   Speranza, L
AF D'Angelo, Chiara
   Franceschelli, Sara
   Quiles, Jose Luis
   Speranza, Lorenza
TI Wide Biological Role of Hydroxytyrosol: Possible Therapeutic and
   Preventive Properties in Cardiovascular Diseases
SO CELLS
LA English
DT Review
DE hydroxytyrosol; cardiovascular disease; atherosclerosis; oxidative
   stress; inflammation; Mediterranean diet
ID VIRGIN OLIVE OIL; VASCULAR ENDOTHELIAL-CELLS; LOW-DENSITY-LIPOPROTEIN;
   PHENOLIC-COMPOUNDS; OXIDATIVE STRESS; PROTECTIVE ROLE; HEART-DISEASE;
   KAPPA-B; ANTIOXIDANT; ACTIVATION
AB The growing incidence of cardiovascular disease (CVD) has promoted investigations of natural molecules that could prevent and treat CVD. Among these, hydroxytyrosol, a polyphenolic compound of olive oil, is well known for its antioxidant, anti-inflammatory, and anti-atherogenic effects. Its strong antioxidant properties are due to the scavenging of radicals and the stimulation of synthesis and activity of antioxidant enzymes (SOD, CAT, HO-1, NOS, COX-2, GSH), which also limit the lipid peroxidation of low-density lipoprotein (LDL) cholesterol, a hallmark of atherosclerosis. Lowered inflammation and oxidative stress and an improved lipid profile were also demonstrated in healthy subjects as well as in metabolic syndrome patients after hydroxytyrosol (HT) supplementation. These results might open a new therapeutic scenario through personalized supplementation of HT in CVDs. This review is the first attempt to collect together scientific literature on HT in both in vitro and in vivo models, as well as in human clinical studies, describing its potential biological effects for cardiovascular health.
C1 [D'Angelo, Chiara; Franceschelli, Sara; Speranza, Lorenza] Univ G dAnnunzio, Dept Med & Aging Sci, Via Vestini 31, I-66100 Chieti, Italy.
   [Quiles, Jose Luis] Univ Granada, Inst Nutr & Food Technol Jose Mataix Verdu, Dept Physiol, Biomed Res Ctr, Granada 18071, Spain.
C3 G d'Annunzio University of Chieti-Pescara; University of Granada
RP Speranza, L (corresponding author), Univ G dAnnunzio, Dept Med & Aging Sci, Via Vestini 31, I-66100 Chieti, Italy.
EM chiara.dangelo@unich.it; sara.franceschelli@unich.it; jlquiles@ugr.es;
   lorenza.speranza@unich.it
RI Franceschelli, Sara/G-1738-2015; D'Angelo, Chiara/AAH-5200-2019; Quiles,
   Jose L./C-6911-2013
OI Quiles, Jose L./0000-0002-9048-9086; Franceschelli,
   Sara/0000-0002-1580-6520; D'ANGELO, Chiara/0000-0002-1477-0706
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NR 103
TC 39
Z9 39
U1 0
U2 24
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2073-4409
J9 CELLS-BASEL
JI Cells
PD SEP
PY 2020
VL 9
IS 9
AR 1932
DI 10.3390/cells9091932
PG 20
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA OD7NA
UT WOS:000580034600001
PM 32825589
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Grattagliano, I
   Montezinho, LP
   Oliveira, PJ
   Frühbeck, G
   Gómez-Ambrosi, J
   Montecucco, F
   Carbone, F
   Wieckowski, MR
   Wang, DQH
   Portincasa, P
AF Grattagliano, Ignazio
   Montezinho, Liliana P.
   Oliveira, Paulo J.
   Fruhbeck, Gema
   Gomez-Ambrosi, Javier
   Montecucco, Fabrizio
   Carbone, Federico
   Wieckowski, Mariusz R.
   Wang, David Q. -H.
   Portincasa, Piero
TI Targeting mitochondria to oppose the progression of nonalcoholic fatty
   liver disease
SO BIOCHEMICAL PHARMACOLOGY
LA English
DT Article
DE Fatty liver; Mitochondria; Nitrosative stress; Nonalcoholic fatty liver
   disease; Oxidative stress
ID PERMEABILITY TRANSITION PORE; PLACEBO-CONTROLLED TRIAL;
   ACID-BINDING-PROTEIN; DE-NOVO LIPOGENESIS; INSULIN-RESISTANCE; OXIDATIVE
   STRESS; METABOLIC SYNDROME; HEPATIC STEATOSIS; VITAMIN-E; RAT-LIVER
AB Nonalcoholic fatty liver disease (NAFLD) is a condition characterized by the excessive accumulation of triglycerides in hepatocytes. NAFLD is the most frequent chronic liver disease in developed countries, and is often associated with metabolic disorders such as obesity and type 2 diabetes. NAFLD definition encompasses a spectrum of chronic liver abnormalities, ranging from simple steatosis (NAFL), to steatohepatitis (NASH), significant liver fibrosis, cirrhosis, and hepatocellular carcinoma. NAFLD, therefore, represents a global public health issue. Mitochondrial dysfunction occurs in NAFLD, and contributes to the progression to the necro-inflammatory and fibrotic form (NASH). Disrupted mitochondrial function is associated with a decrease in the energy levels and impaired redox balance, and negatively affects cell survival by altering overall metabolism and subcellular trafficking. Such events reduce the tolerance of hepatocytes towards damaging hits, and favour the injurious effects of extra-cellular factors. Here, we discuss the role of mitochondria in NAFLD and focus on potential therapeutic approaches aimed at preserving mitochondrial function.
C1 [Grattagliano, Ignazio; Portincasa, Piero] Univ Bari, Med Sch, Dept Biomed Sci & Human Oncol, Clin Med A Murri, Bari, Italy.
   [Grattagliano, Ignazio] Italian Coll Gen Practitioners & Primary Care, Bari, Italy.
   [Montezinho, Liliana P.; Oliveira, Paulo J.] Univ Coimbra, CNC Ctr Neurosci & Cell Biol, UC Biotech Bldg,Biocant Pk, Cantanhede, Portugal.
   [Montezinho, Liliana P.] Escola Univ Vasco da Gama, Dept Vet Med, CIVG, Coimbra, Portugal.
   [Fruhbeck, Gema; Gomez-Ambrosi, Javier] Clin Univ Navarra, Metab Res Lab, Pamplona, Spain.
   [Fruhbeck, Gema; Gomez-Ambrosi, Javier] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr CIBEROBN, Pamplona, Spain.
   [Fruhbeck, Gema; Gomez-Ambrosi, Javier] Inst Invest Sanitaria Navarra IdiSNA, Obes & Adipobiol Grp, Pamplona, Spain.
   [Fruhbeck, Gema] Clin Univ Navarra, Dept Endocrinol & Nutr, Pamplona, Spain.
   [Montecucco, Fabrizio; Carbone, Federico] Univ Genoa, Dept Internal Med, Clin Internal Med 1, 6 Viale Benedetto XV, I-16132 Genoa, Italy.
   [Montecucco, Fabrizio] Osped Policlin San Martino, 10 Largo Benzi, I-16132 Genoa, Italy.
   [Montecucco, Fabrizio] Univ Genoa, CEBR, 9 Viale Benedetto XV, I-16132 Genoa, Italy.
   [Wieckowski, Mariusz R.] PAS, Nencki Inst Expt Biol, Warsaw, Poland.
   [Wang, David Q. -H.] Albert Einstein Coll Med, Marion Bessin Liver Res Ctr, Div Gastroenterol & Liver Dis, Dept Med, Bronx, NY 10461 USA.
C3 Universita degli Studi di Bari Aldo Moro; Universidade de Coimbra;
   University of Navarra; Instituto de Salud Carlos III; CIBER - Centro de
   Investigacion Biomedica en Red; CIBEROBN; University of Navarra;
   University of Genoa; University of Genoa; Polish Academy of Sciences;
   Nencki Institute of Experimental Biology of the Polish Academy of
   Sciences; Yeshiva University; Montefiore Medical Center; Albert Einstein
   College of Medicine
RP Portincasa, P (corresponding author), Univ Bari, Med Sch, Clin Med A Murri, Dept Biosci & Human Oncol DIMO,Policlin Hosp, I-70124 Bari, Italy.
EM piero.portincasa@uniba.it
RI Gómez-Ambrosi, Javier/D-2984-2017; wang, David/KFR-2555-2024;
   Wieckowski, Mariusz/ABF-1565-2022; Oliveira, Paulo/AAQ-8943-2020;
   portincasa, piero/J-7245-2018; Oliveira, Paulo/H-1980-2011; Carbone,
   Federico/G-3650-2013
OI Pereira Montezinho, Liliana Cristina/0000-0002-6877-4286; Oliveira,
   Paulo/0000-0002-5201-9948; Carbone, Federico/0000-0003-2957-4078;
   Wieckowski, Mariusz/0000-0003-0789-4521
FU FOIE GRAS project; mtFOIE GRAS project; European Union [722619, 734719]
FX M.R.W., P.J.O., and P.P., gratefully acknowledge the financial support
   for this research from the FOIE GRAS and mtFOIE GRAS projects. These
   projects received funding from the European Union's Horizon 2020
   Research and Innovation programme under the Marie Sklodowska-Curie Grant
   Agreement No. 722619 (FOIE GRAS) and Grant Agreement No. 734719 (mtFOIE
   GRAS).
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NR 162
TC 46
Z9 48
U1 1
U2 39
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0006-2952
EI 1873-2968
J9 BIOCHEM PHARMACOL
JI Biochem. Pharmacol.
PD FEB
PY 2019
VL 160
BP 34
EP 45
DI 10.1016/j.bcp.2018.11.020
PG 12
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA HK3JW
UT WOS:000457813500004
PM 30508523
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Yutani, R
   Venketaraman, V
   Sheren, N
AF Yutani, Ray
   Venketaraman, Vishwanath
   Sheren, Nisar
TI Treatment of Acute and Long-COVID, Diabetes, Myocardial Infarction, and
   Alzheimer's Disease: The Potential Role of a Novel Nano-Compound-The
   Transdermal Glutathione-Cyclodextrin Complex
SO ANTIOXIDANTS
LA English
DT Review
DE oxidative stress; reactive oxygen species; antioxidants; glutathione;
   glutathione-cyclodextrin complex
ID OXIDATIVE STRESS; METABOLIC SYNDROME; MITOCHONDRIAL DYSFUNCTION;
   HUNTINGTONS-DISEASE; REDOX IMBALANCE; NEUROINFLAMMATION; PROGRESSION;
   RETINOPATHY; OBESITY; INJURY
AB Oxidative stress (OS) occurs from excessive reactive oxygen species or a deficiency of antioxidants-primarily endogenous glutathione (GSH). There are many illnesses, from acute and post-COVID-19, diabetes, myocardial infarction to Alzheimer's disease, that are associated with OS. These dissimilar illnesses are, in order, viral infections, metabolic disorders, ischemic events, and neurodegenerative disorders. Evidence is presented that in many illnesses, (1) OS is an early initiator and significant promotor of their progressive pathophysiologic processes, (2) early reduction of OS may prevent later serious and irreversible complications, (3) GSH deficiency is associated with OS, (4) GSH can likely reduce OS and restore adaptive physiology, (5) effective administration of GSH can be accomplished with a novel nano-product, the GSH/cyclodextrin (GC) complex. OS is an overlooked pathological process of many illnesses. Significantly, with the GSH/cyclodextrin (GC) complex, therapeutic administration of GSH is now available to reduce OS. Finally, rigorous prospective studies are needed to confirm the efficacy of this therapeutic approach.
C1 [Yutani, Ray] Western Univ Hlth Sci, Coll Osteopath Med Pacific, Dept Family Med, Pomona, CA 91766 USA.
   [Venketaraman, Vishwanath] Western Univ Hlth Sci, Coll Osteopath Med Pacific, Dept Basic Med Sci, Pomona, CA 91766 USA.
   [Sheren, Nisar] Western Univ Hlth Sci, Coll Osteopath Med Pacific, Pomona, CA 91766 USA.
C3 Western University of Health Sciences; Western University of Health
   Sciences; Western University of Health Sciences
RP Yutani, R (corresponding author), Western Univ Hlth Sci, Coll Osteopath Med Pacific, Dept Family Med, Pomona, CA 91766 USA.
EM ryutani@westernu.edu; vvenketaraman@westernu.edu;
   nisar.sheren@westernu.edu
RI venketaraman, Vishwanath/AAW-6945-2020
OI venketaraman, Vishwanath/0000-0002-2586-1160
FX This research received no external funding.
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NR 258
TC 0
Z9 0
U1 4
U2 4
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD SEP
PY 2024
VL 13
IS 9
AR 1106
DI 10.3390/antiox13091106
PG 31
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA H5C4X
UT WOS:001323618100001
PM 39334765
OA gold
DA 2025-06-11
ER

PT J
AU Liu, N
   Xu, H
   Sun, QQ
   Yu, XJ
   Chen, WT
   Wei, HQ
   Jiang, J
   Xu, YZ
   Lu, WJ
AF Liu, Ning
   Xu, Hu
   Sun, Qianqian
   Yu, Xiaojuan
   Chen, Wentong
   Wei, Hongquan
   Jiang, Jie
   Xu, Youzhi
   Lu, Wenjie
TI The Role of Oxidative Stress in Hyperuricemia and Xanthine
   Oxidoreductase (XOR) Inhibitors
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Article
AB Uric acid is the end product of purine metabolism in humans. Hyperuricemia is a metabolic disease caused by the increased formation or reduced excretion of serum uric acid (SUA). Alterations in SUA homeostasis have been linked to a number of diseases, and hyperuricemia is the major etiologic factor of gout and has been correlated with metabolic syndrome, cardiovascular disease, diabetes, hypertension, and renal disease. Oxidative stress is usually defined as an imbalance between free radicals and antioxidants in our body and is considered to be one of the main causes of cell damage and the development of disease. Studies have demonstrated that hyperuricemia is closely related to the generation of reactive oxygen species (ROS). In the human body, xanthine oxidoreductase (XOR) catalyzes the oxidative hydroxylation of hypoxanthine to xanthine to uric acid, with the accompanying production of ROS. Therefore, XOR is considered a drug target for the treatment of hyperuricemia and gout. In this review, we discuss the mechanisms of uric acid transport and the development of hyperuricemia, emphasizing the role of oxidative stress in the occurrence and development of hyperuricemia. We also summarize recent advances and new discoveries in XOR inhibitors.
C1 [Liu, Ning; Xu, Hu; Sun, Qianqian; Yu, Xiaojuan; Chen, Wentong; Wei, Hongquan; Jiang, Jie; Xu, Youzhi; Lu, Wenjie] Anhui Med Univ, Basic Med Coll, Hefei 230032, Peoples R China.
   [Jiang, Jie] Anhui Med Univ, Coll Pharm, Hefei 230032, Peoples R China.
C3 Anhui Medical University; Anhui Medical University
RP Xu, YZ; Lu, WJ (corresponding author), Anhui Med Univ, Basic Med Coll, Hefei 230032, Peoples R China.
EM xuyouzhi@ahmu.edu.cn; wenjie63136@163.com
RI Sun, Qianqian/KVY-2334-2024; Yu, Xiaojuan/AAA-9685-2020
OI lu, wenjie/0000-0003-1741-2311; LIU, NING/0000-0003-2822-0577
FU National Natural Sciences Foundation of China [81700763, 81402947];
   China Postdoctoral Science Foundation [2015M581974]; Postdoctoral
   Science Foundation of Anhui Province [2017B162]
FX This work was supported by the National Natural Sciences Foundation of
   China (81700763, and 81402947), China Postdoctoral Science Foundation
   funded project (2015M581974) and the Postdoctoral Science Foundation of
   Anhui Province (2017B162). Useful suggestions given by Zhirui Fang of
   Anhui Medical University are also acknowledged.
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NR 160
TC 138
Z9 150
U1 3
U2 65
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PD MAR 27
PY 2021
VL 2021
AR 1470380
DI 10.1155/2021/1470380
PG 15
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA RJ1VA
UT WOS:000637388300002
PM 33854690
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Engin, AB
   Tsatsakis, AM
   Tsoukalas, D
   Engin, A
AF Engin, Ayse Basak
   Tsatsakis, Aristidis M.
   Tsoukalas, Dimitris
   Engin, Atilla
TI Do flavanols-rich natural products relieve obesity-related insulin
   resistance?
SO FOOD AND CHEMICAL TOXICOLOGY
LA English
DT Review
DE Insulin resistance; Obesity; Polyphenols; Cocoa; Coffee; G
   protein-coupled estrogen receptor
ID NONALCOHOLIC FATTY LIVER; DIET-INDUCED OBESITY; PROTEIN-KINASE-C;
   ADIPOSE-TISSUE; MITOCHONDRIAL DYSFUNCTION; ENDOTHELIAL FUNCTION;
   BLOOD-PRESSURE; METABOLIC SYNDROME; OXIDATIVE STRESS; DARK CHOCOLATE
AB Growing evidence support that insulin resistance may occur as a severe problem due to chronic energetic overfeeding and subsequent obesity. When an abundance of glucose and saturated fat enter the cell, impaired blood flow, hypoxia, inflammation and macrophage infiltration in obese adipose tissue may induce oxidative stress and insulin resistance. Excessive circulating saturated fatty acids ectopically accumulate in insulin-sensitive tissues and impair insulin action. In this context, excessive hepatic lipid accumulation may play a central, pathogenic role in insulin resistance. It is thought that dietary polyphenols may ameliorate obesity-related insulin resistance by attenuating inflammatory responses and oxidative stress. The most often occurring natural polyphenolic compounds are flavonoids. In this review, the possible mechanistic effect of flavonoid-rich natural products on insulin resistance-related metabolic pathways is discussed. Polyphenol intake can prevent high-fat diet-induced insulin resistance via cell surface G protein-coupled estrogen receptors by upregulating the expression of related genes, and their pathways, which are responsible for the insulin sensitivity.
C1 [Engin, Ayse Basak] Gazi Univ, Fac Pharm, Dept Toxicol, TR-06330 Ankara, Turkey.
   [Tsatsakis, Aristidis M.] Univ Crete, Med Sch, Lab Toxicol & Forens, Iraklion, Crete, Greece.
   [Tsoukalas, Dimitris] Univ Crete, Med Sch, Lab Toxicol, Iraklion, Crete, Greece.
   [Engin, Atilla] Gazi Univ, Fac Med, Dept Gen Surg, Ankara, Turkey.
C3 Gazi University; University of Crete; University of Crete; Gazi
   University
RP Engin, AB (corresponding author), Gazi Univ, Fac Pharm, Dept Toxicol, TR-06330 Ankara, Turkey.
EM abengin@gmail.com
RI TSOUKALAS, DIMITRIS/JNS-3199-2023; TSATSAKIS, ARISTIDIS/H-2890-2013
OI TSATSAKIS, ARISTIDIS/0000-0003-3824-2462; Engin, Ayse
   Basak/0000-0003-1300-4644; Tsoukalas, Dimitris/0000-0001-6885-6209
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NR 170
TC 21
Z9 23
U1 0
U2 47
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0278-6915
EI 1873-6351
J9 FOOD CHEM TOXICOL
JI Food Chem. Toxicol.
PD FEB
PY 2018
VL 112
BP 157
EP 167
DI 10.1016/j.fct.2017.12.055
PG 11
WC Food Science & Technology; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Toxicology
GA FW8GN
UT WOS:000425568900018
PM 29288757
DA 2025-06-11
ER

PT J
AU González-Garibay, AS
   Sandoval, G
   Torres-González, OR
   Bastidas-Ramírez, BE
   Sánchez-Hernández, IM
   Padilla-Camberos, E
AF Gonzalez-Garibay, Angelica Sofia
   Sandoval, Georgina
   Torres-Gonzalez, Omar Ricardo
   Bastidas-Ramirez, Blanca Estela
   Sanchez-Hernandez, Ivan Moises
   Padilla-Camberos, Eduardo
TI Agave-Laurate-Bioconjugated Fructans Decrease Hyperinsulinemia and
   Insulin Resistance, Whilst Increasing IL-10 in Rats with Metabolic
   Syndrome Induced by a High-Fat Diet
SO PHARMACEUTICALS
LA English
DT Article
DE adipokines; inflammation; adipose tissue; fructooligosaccharides;
   acylation
ID APPETITE REGULATION; OXIDATIVE STRESS; QUANTITATIVE PCR;
   GENE-EXPRESSION; BODY-WEIGHT; OLIGOFRUCTOSE; WISTAR; ACID; HYPERTENSION;
   INFLAMMATION
AB Metabolic syndrome (MetS) comprises a cluster of metabolic risk factors, which include obesity, hypertriglyceridemia, high blood pressure, and insulin resistance. The purpose of this study was to evaluate the effects of laurate-bioconjugated fructans on pro- and anti-inflammatory cytokines in Wistar rats with MetS induced by a high-fat diet. Laurate-bioconjugated fructans were synthesized with agave fructans, immobilized lipase B, and vinyl laureate as the acylant. Groups were fed a standard diet (NORMAL), a high-fat diet (HFD), or a high-fat diet plus laurate-bioconjugated fructans (FL PREV) for 9 weeks. A fourth group received a high-fat diet for 6 weeks, followed by simultaneous exposure to a high-fat diet and laurate-bioconjugated fructans for 3 additional weeks (FL REV). The dose of laurate-bioconjugated fructans was 130 mg/kg. Laurate-bioconjugated fructans reduced food and energy intake, body weight, body mass index, abdominal circumference, adipose tissue, adipocyte area, serum triglycerides, insulin, insulin resistance, and C-reactive protein but they increased IL-10 protein serum levels and mRNA expression. The impact of laurate-bioconjugated fructans on zoometric and metabolic parameters supports their potential as therapeutic agents to improve obesity, obesity comorbidities, insulin resistance, type 2 diabetes mellitus, and MetS.
C1 [Gonzalez-Garibay, Angelica Sofia; Sandoval, Georgina; Torres-Gonzalez, Omar Ricardo; Sanchez-Hernandez, Ivan Moises; Padilla-Camberos, Eduardo] Ctr Res & Assistance Technol & Design State Jalisc, Med & Pharmaceut Biotechnol Unit, AC CIATEJ, Ave Normalistas 800 Col Colinas Normal, Guadalajara 44270, Jalisco, Mexico.
   [Gonzalez-Garibay, Angelica Sofia; Bastidas-Ramirez, Blanca Estela] Univ Guadalajara, Univ Ctr Hlth Sci, Inst Res Chron Degenerat Dis, Dept Mol Biol & Genom, Sierra Mojada 950, Guadalajara 44340, Jalisco, Mexico.
C3 CIATEJ - Centro de Investigacion & Asistencia en Tecnologia & Diseno del
   Estado de Jalisco; Universidad de Guadalajara
RP Padilla-Camberos, E (corresponding author), Ctr Res & Assistance Technol & Design State Jalisc, Med & Pharmaceut Biotechnol Unit, AC CIATEJ, Ave Normalistas 800 Col Colinas Normal, Guadalajara 44270, Jalisco, Mexico.
EM epadilla@ciatej.mx
RI Sandoval, Georgina/ABB-8999-2020; Gonzalez Garibay, Angelica
   Sofia/KFQ-1753-2024; Padilla Camberos, Eduardo/ABA-8863-2021; Sandoval,
   Georgina/C-3327-2008
OI Sandoval, Georgina/0000-0002-9105-0702; Padilla-Camberos,
   Eduardo/0000-0003-4783-841X; Gonzalez Garibay, Angelica
   Sofia/0000-0001-6754-1635
FU Consejo Nacional de Humanidades, Ciencia y Tecnologia (CONAHCYT)
   [3097257, CVU 298099]
FX This research was also supported by a postdoctoral fellowship No.
   3097257 from Consejo Nacional de Humanidades, Ciencia y Tecnologia
   (CONAHCYT), to Angelica Sofia Gonzalez Garibay (CVU 298099). This study
   received no external funding.
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NR 84
TC 0
Z9 0
U1 1
U2 1
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1424-8247
J9 PHARMACEUTICALS-BASE
JI Pharmaceuticals
PD AUG
PY 2024
VL 17
IS 8
AR 1036
DI 10.3390/ph17081036
PG 18
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA E8M9O
UT WOS:001305498100001
PM 39204141
OA gold
DA 2025-06-11
ER

PT J
AU Yang, QY
   Guo, XL
   Chen, YJ
   Zhang, W
   Ren, J
   Wang, JY
   Tang, NJ
   Gao, A
AF Yang, Qiaoyun
   Guo, Xiaoli
   Chen, Yujiao
   Zhang, Wei
   Ren, Jing
   Wang, Jingyu
   Tang, Naijun
   Gao, Ai
TI Blood levels of perfluoroalkyl substances (PFASs), elements and their
   associations with metabolic syndrome (MetS) in Chinese male adults
   mediated by metabolic-related risk factors
SO SCIENCE OF THE TOTAL ENVIRONMENT
LA English
DT Article
DE Metabolic syndrome; Perfluoroalkyl substances; Trace element; Heavy
   metal; Metabolic risk factors
ID PERFLUOROOCTANOIC ACID; TRACE-ELEMENTS; BILE-ACIDS; LEPTIN; EXPOSURE;
   OBESITY; STRESS
AB Our preliminary studies have suggested PFASs, heavy metals, and trace elements could bring significant risks to MetS. However, the role of epigenetic mechanisms (i.e., miRNAs) and risk factors of metabolic alternation (i.e., thyroid functions, glucose and lipids metabolism) are not fully understood. To test this hypothesis, a further cross-sectional study with 80 male MetS cases and 64 male references was undertaken. Negative association between the serum n-perfluorooctanoic add (n-PFOA) with miR-140-5p was found [beta = -0.772; 95% confidence interval (CI), -0244 to -0.300: p < 0.01, q < 0.05)] after adjusted with age. Higher levels of leptin and total bile add were observed in the MetS group. The significantly positive associations between leptin with Cd (beta = 1.015, p < 0.01, q < 0.05), Cu (beta = 6.796, p < 0.05, q = 0.077) and Se (beta = 7.633, p < 0.05, q = 0.060) were found; whereas total bile add was significantly associated with Se (beta = 8.954, p < 0.05. q = 0.140). Significantly positive associations between leptin and systolic/diastolic blood pressure were showed. Moreover, increased acid concentrations were associated with hypertriglyceridernia [odds ratio (OR): 2.24 (MCI, 1.10-4.58) ad- justed by age. (C) 2020 Published by Elsevier B.V.
C1 [Yang, Qiaoyun; Tang, Naijun] Tianjin Med Univ, Sch Publ Hlth, Dept Occupat & Environm Hlth, Tianjin Key Lab Environm Nutr & Publ Hlth, Tianjin 300070, Peoples R China.
   [Yang, Qiaoyun; Tang, Naijun] Tianjin Med Univ, Natl Demonstrat Ctr Expt Prevent Med Educ, Tianjin 300070, Peoples R China.
   [Guo, Xiaoli; Chen, Yujiao; Zhang, Wei; Ren, Jing; Wang, Jingyu; Gao, Ai] Capital Med Univ, Sch Publ Hlth, Dept Occupat Hlth & Environm Hlth, Beijing 100069, Peoples R China.
   [Guo, Xiaoli; Chen, Yujiao; Zhang, Wei; Ren, Jing; Wang, Jingyu; Gao, Ai] Capital Med Univ, Beijing Key Lab Environm Toxicol, Beijing 100069, Peoples R China.
C3 Tianjin Medical University; Tianjin Medical University; Capital Medical
   University; Capital Medical University
RP Gao, A (corresponding author), 10 Xitoutiao, Beijing 100069, Peoples R China.; Tang, NJ (corresponding author), 22 Qixiangtai, Tianjin 300070, Peoples R China.
EM tangnaijun@tmu.edu.cn; gaoai0980@163.com
RI , 北杨/AGD-8087-2022
OI Gao, Ai/0000-0002-0764-4656; Yang, Qiaoyun/0000-0002-0906-3038
FU National Natural Science Foundation of China [81773397, 81703192];
   Beijing Natural Science Foundation Programand Scientific Research Key
   Programof BeijingMunicipal Commission of Education [KZ201810025032];
   Support Project of High-level Teachers in Beijing Municipal Universities
   in the Period of 13th Five-year Plan [CITTCD 20170323]; Natural Science
   Foundation of Tianjin City [17JCQNJC10300]
FX This research was supported by the National Natural Science Foundation
   of China (81773397, 81703192), the Beijing Natural Science Foundation
   Programand Scientific Research Key Programof BeijingMunicipal Commission
   of Education (KZ201810025032), the Support Project of High-level
   Teachers in Beijing Municipal Universities in the Period of 13th
   Five-year Plan (CIT&TCD 20170323), Natural Science Foundation of Tianjin
   City (17JCQNJC10300). We thank the volunteers who participated in this
   study.
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NR 25
TC 8
Z9 8
U1 3
U2 33
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0048-9697
EI 1879-1026
J9 SCI TOTAL ENVIRON
JI Sci. Total Environ.
PD NOV 10
PY 2020
VL 742
AR 140595
DI 10.1016/j.scitotenv.2020.140595
PG 7
WC Environmental Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology
GA NO3WF
UT WOS:000569415800004
PM 32629270
DA 2025-06-11
ER

PT J
AU Borém, LMA
   Neto, JFR
   Brandi, IV
   Lelis, DF
   Santos, SHS
AF Borem, Luciana M. A.
   Neto, Joao F. R.
   Brandi, Igor, V
   Lelis, Deborah F.
   Santos, Sergio H. S.
TI The role of the angiotensin II type I receptor blocker telmisartan in
   the treatment of non-alcoholic fatty liver disease: a brief review
SO HYPERTENSION RESEARCH
LA English
DT Review
ID DIET-INDUCED OBESITY; RENIN-ANGIOTENSIN; INSULIN-RESISTANCE; METABOLIC
   SYNDROME; HEPATIC-FIBROSIS; ALDOSTERONE SYSTEM; GLUCOSE-METABOLISM;
   OXIDATIVE STRESS; TRANSGENIC RATS; ADIPOSE-TISSUE
AB Non-alcoholic fatty liver disease (NAFLD) is currently considered an important component of metabolic syndrome (MetS). The spectrum of NAFLD includes conditions that range from simple hepatic steatosis to non-alcoholic steatohepatitis. NAFLD is correlated with liver-related death and is predicted to be the most frequent indication for liver transplantation by 2030. Insulin resistance is directly correlated to the central mechanisms of hepatic steatosis in NAFLD patients, which is strongly correlated to the imbalance of the renin-angiotensin system, that is involved in lipid and glucose metabolism. Among the emerging treatment approaches for NAFLD is the anti-hypertensive agent telmisartan, which has positive effects on liver, lipid, and glucose metabolism, especially through its action on the renin-angiotensin system, by blocking the ACE/AngII/AT1 axis and increasing ACE2/Ang(1-7)/Mas axis activation. However, treatment with this drug is only recommended for patients with an established indication for anti-hypertensive therapy. Thus, there is an increased need for large randomized controlled trials with the aim of elucidating the effects of telmisartan on liver disease, especially NAFLD. From this perspective, the present review aims to provide a brief examination of the pathogenesis of NAFLD/NASH and the role of telmisartan on preventing liver disorders and thus to improve the discussion on potential therapies.
C1 [Borem, Luciana M. A.; Neto, Joao F. R.; Lelis, Deborah F.; Santos, Sergio H. S.] Univ Estadual Montes Claros Unimontes, Postgrad Program Hlth Sci, Lab Hlth Sci, Montes Claros, MG, Brazil.
   [Borem, Luciana M. A.] Fac Integradas Pitagoras, Med Dept, Montes Claros, MG, Brazil.
   [Brandi, Igor, V; Santos, Sergio H. S.] UFMG, Food Engn Coll, Inst Agr Sci, Montes Claros, MG, Brazil.
C3 Universidade Estadual de Montes Claros; Universidade Federal de Minas
   Gerais
RP Santos, SHS (corresponding author), Univ Estadual Montes Claros Unimontes, Postgrad Program Hlth Sci, Lab Hlth Sci, Montes Claros, MG, Brazil.; Santos, SHS (corresponding author), UFMG, Food Engn Coll, Inst Agr Sci, Montes Claros, MG, Brazil.
EM sergiosousas@hotmail.com
RI Brandi, Igor/L-6108-2017; Santos, Sérgio/D-8143-2011
OI Viana Brandi, Igor/0000-0001-6714-7996; Santos,
   Sergio/0000-0002-7788-5447
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NR 120
TC 42
Z9 45
U1 0
U2 12
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0916-9636
EI 1348-4214
J9 HYPERTENS RES
JI Hypertens. Res.
PD JUN
PY 2018
VL 41
IS 6
BP 394
EP 405
DI 10.1038/s41440-018-0040-6
PG 12
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA GI2IF
UT WOS:000434192500002
PM 29636553
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Zhang, H
   Li, Y
   Su, WP
   Ying, ZX
   Zhou, L
   Zhang, LL
   Wang, T
AF Zhang, Hao
   Li, Yue
   Su, Weipeng
   Ying, Zhixiong
   Zhou, Le
   Zhang, Lili
   Wang, Tian
TI Resveratrol attenuates mitochondrial dysfunction in the liver of
   intrauterine growth retarded suckling piglets by improving mitochondrial
   biogenesis and redox status
SO MOLECULAR NUTRITION & FOOD RESEARCH
LA English
DT Article
DE Intrauterine growth retardation; Metabolic syndrome; Mitochondrial
   biogenesis; Oxidative phosphorylation; Piglet; Resveratrol
ID ENERGY-METABOLISM; OXIDATIVE STRESS; PPAR-ALPHA; SIRT1; ACTIVATION;
   ACCUMULATION; HYPERTROPHY; PGC-1-ALPHA; DEFICIENCY; PROTECTS
AB Scope: Emerging evidence has identified mitochondrial biogenesis and oxidative phosphorylation as potential targets for the prevention and treatment of metabolic syndrome. This study investigated the effect of resveratrol (RSV) on hepatic mitochondrial function in intrauterine growth-retarded (IUGR) suckling piglets.
   Methods and results: Seven normal birth weight (NBW) and fourteen IUGR neonatal male piglets were selected. Piglets were fed control diets supplemented with 0 (NBW-CON), 0 (IUGR-CON), and 1.0 (IUGR-RSV) g RSV per kg of milk dry matter from 7 to 21 days of age (n = 7), respectively. Mitochondrial function, swelling, and redox status in the liver were assessed. Compared with NBW, IUGR impaired hepatic mitochondrial biogenesis and energy homeostasis of the control piglets. IUGR control piglets showed overproduction of superoxide radicals, increased concentration of malondialdehyde, and marked swelling in the mitochondria. RSV improved mitochondrial DNA content, ATP production, and fatty acid oxidation in the liver of IUGR piglets, along with an increased activity of sirtuin 1. RSV inhibited mitochondrial superoxide anion accumulation, increased complex III and manganese superoxide dismutase activities, and ameliorated mitochondrial swelling and lipid peroxidation in the IUGR piglets.
   Conclusion: RSV may have beneficial effects in improving hepatic mitochondrial function and redox status in the IUGR piglets.
C1 [Zhang, Hao; Li, Yue; Su, Weipeng; Ying, Zhixiong; Zhou, Le; Zhang, Lili; Wang, Tian] Nanjing Agr Univ, Coll Anim Sci & Technol, Nanjing, Jiangsu, Peoples R China.
C3 Nanjing Agricultural University
RP Wang, T (corresponding author), Nanjing Agr Univ, Coll Anim Sci & Technol, Nanjing, Jiangsu, Peoples R China.
EM tianwangnjau@163.com
OI Wang, Tian/0000-0002-9038-5009
FU National Basic Research Program of People's Republic of China
   [2012CB124703]
FX The research was supported by the National Basic Research Program of
   People's Republic of China (Grant No: 2012CB124703).
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NR 45
TC 54
Z9 60
U1 0
U2 44
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1613-4125
EI 1613-4133
J9 MOL NUTR FOOD RES
JI Mol. Nutr. Food Res.
PD MAY
PY 2017
VL 61
IS 5
AR 1600653
DI 10.1002/mnfr.201600653
PG 12
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA EX2VG
UT WOS:000403086800011
PM 27958670
DA 2025-06-11
ER

PT J
AU Prieto, MAV
   Bettaieb, A
   Lanzi, CR
   Soto, VC
   Perdicaro, DJ
   Galmarini, CR
   Haj, FG
   Miatello, RM
   Oteiza, PI
AF Vazquez Prieto, Marcela A.
   Bettaieb, Ahmed
   Rodriguez Lanzi, Cecilia
   Soto, Veronica C.
   Perdicaro, Diahann J.
   Galmarini, Claudio R.
   Haj, Fawaz G.
   Miatello, Roberto M.
   Oteiza, Patricia I.
TI Catechin and quercetin attenuate adipose inflammation in fructose-fed
   rats and 3T3-L1 adipocytes
SO MOLECULAR NUTRITION & FOOD RESEARCH
LA English
DT Article
DE Adipokines; Adipose tissue inflammation; Flavonoids; High fructose diet;
   Metabolic syndrome
ID NECROSIS-FACTOR-ALPHA; METABOLIC SYNDROME; INSULIN-RESISTANCE; VISCERAL
   ADIPOSITY; DIETARY FRUCTOSE; PPAR-GAMMA; GREEN TEA; EXPRESSION; GLUCOSE;
   OBESITY
AB Scope: This study evaluated the capacity of dietary catechin (C), quercetin (Q), and the combination of both (CQ), to attenuate adipose inflammation triggered by high fructose (HFr) consumption in rats and by tumor necrosis factor alpha (TNF-alpha) in 3T3-L1 adipocytes.
   Methods and results: In rats, HFr consumption for 6 wk caused dyslipidemia, insulin resistance, reduced plasma adiponectin, adiposity, and adipose tissue inflammation. Dietary supplementation with 20 mg/kg/day of C, Q, and CQ improved all these parameters. In 3T3-L1 adipocytes, C and Q attenuated TNF-alpha-induced elevated protein carbonyls, increased proin-flammatory cytokine expression (MCP-1, resistin), and decreased adiponectin. The protective effects of C and Q on adipose inflammation are in part associated with their capacity to (i) decrease the activation of the mitogen-activated kinases (MAPKs) JNK and p38; and (ii) prevent the downregulation of PPAR-gamma. In summary, C and Q, and to a larger extent the combination of both, attenuated adipose proinflammatory signaling cascades and regulated the balance of molecules that improve (adiponectin) or impair (TNF-alpha, MCP-1, resistin) insulin sensitivity.
   Conclusion: Together, these findings suggest that dietary Q and C may have potential benefits in mitigating MetS-associated adipose inflammation, oxidative stress, and insulin resistance.
C1 [Vazquez Prieto, Marcela A.; Rodriguez Lanzi, Cecilia; Perdicaro, Diahann J.; Miatello, Roberto M.] Univ Nacl Cuyo, Fac Ciencias Med, Area Fisiol Patol, RA-5500 Mendoza, Argentina.
   [Vazquez Prieto, Marcela A.; Rodriguez Lanzi, Cecilia; Perdicaro, Diahann J.; Miatello, Roberto M.] Inst Med & Biol Expt Cuyo IMBECU CONICET, Mendoza, Argentina.
   [Bettaieb, Ahmed; Haj, Fawaz G.; Oteiza, Patricia I.] Univ Calif Davis, Dept Nutr, Davis, CA 95616 USA.
   [Soto, Veronica C.] Inst Biol Agr Mendoza IBAM CONICET, Mendoza, Argentina.
   [Soto, Veronica C.; Galmarini, Claudio R.] Univ Nacl Cuyo, Fac Ciencias Agr, Inst Hort, RA-5500 Mendoza, Argentina.
   [Haj, Fawaz G.] Univ Calif Davis, Dept Internal Med, Davis, CA 95616 USA.
   [Oteiza, Patricia I.] Univ Calif Davis, Dept Environm Toxicol, Davis, CA 95616 USA.
C3 University Nacional Cuyo Mendoza; Consejo Nacional de Investigaciones
   Cientificas y Tecnicas (CONICET); University of California System;
   University of California Davis; University Nacional Cuyo Mendoza;
   University of California System; University of California Davis;
   University of California System; University of California Davis
RP Prieto, MAV (corresponding author), Natl Univ Cuyo, Sch Med, Av Libertador 80, RA-5500 Mendoza, Argentina.
EM mvazquez@fcm.uncu.edu.ar
RI Prieto, Marcela/W-4291-2019; Soto, Veronica/ADE-5381-2022
OI Galmarini, Claudio/0000-0002-7958-0110; Rodriguez Lanzi, Maria
   Cecilia/0000-0002-4878-0427
FU Programa I+D Universidad Nacional de Cuyo; PIP CONICET; NIFA-USDA
   [CA-D*-xxx-7244-H]; NIH [R01DK090492, R01DK095359, K99DK100736]; 
   [PICT-2011-1957]
FX This work was supported by Programa I+D 2010 Universidad Nacional de
   Cuyo and PIP CONICET to M.A.V.P. and R.M.M.; PICT-2011-1957 to M.A.V.P.;
   NIFA-USDA (CA-D*-xxx-7244-H) to P.I.O.; NIH (R01DK090492 and
   R01DK095359) to F.G.H., and K99DK100736 to A.B. The authors thank Susana
   Gonzalez and Cristina Lama for their technical assistance.
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NR 55
TC 93
Z9 98
U1 1
U2 45
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1613-4125
EI 1613-4133
J9 MOL NUTR FOOD RES
JI Mol. Nutr. Food Res.
PD APR
PY 2015
VL 59
IS 4
BP 622
EP 633
DI 10.1002/mnfr.201400631
PG 12
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA CF8CK
UT WOS:000352782800003
PM 25620282
OA Green Accepted, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Sivakumar, AS
   Viswanathan, P
   Anuradha, CV
AF Sivakumar, Allur S.
   Viswanathan, P.
   Anuradha, Carani V.
TI Dose-dependent effect of galangin on fructose-mediated insulin
   resistance and oxidative events in rat kidney
SO REDOX REPORT
LA English
DT Article
DE fructose; galangin; insulin resistance; kidney; antioxidants
ID SENSITIVITY; GLYCOSYLATION; INHIBITION; FLAVONOIDS; IMPROVES; WISTAR;
   LIVER
AB Galangin is an antioxidant flavonol present in high concentrations in the rhizome of Alpinia galanga. We investigated the effect of galangin on whole-body insulin resistance and kidney oxidative stress in a fructose-induced rat model of metabolic syndrome. Male albino Wistar rats were divided into 6 groups containing six animals each. Groups I and VI received a starch-based control diet, while groups II, III, IV and V were fed a high fructose diet (60 g/100 g). Groups III, IV and V additionally received galangin (50, 100 and 200 mu g/kg body weight, respectively) while group VI received 200 mu g galangin/kg body weight. At the end of 60 days, fructose-fed rats exhibited insulin resistance, increased levels of peroxidation end products and diminished antioxidant status. galangin, dose-dependently normalized blood glucose and insulin levels. The minimum effective dose was 100 mu g galangin/kg body weight. At this dose, galangin also prevented the development of insulin resistance and the exaggerated the response to oral glucose challenge. The oxidant-antioxidant balance was maintained by galangin. Micro-albuminuria and tubular and glomerular changes observed in fructose-treated rats were significantly prevented by galangin (100 mu g/kg body weight). These findings imply that galangin potentiates insulin sensitivity and antioxidant capacity and reduces renal damage in this dietary model of metabolic syndrome.
C1 [Sivakumar, Allur S.; Anuradha, Carani V.] Annamalai Univ, Dept Biochem & Biotechnol, Fac Sci, Annamalainagar 608002, Tamil Nadu, India.
   [Viswanathan, P.] Annamalai Univ, Dept Pathol, Fac Med, Rajah Muthaih Med Coll, Annamalainagar 608002, Tamil Nadu, India.
C3 Annamalai University; Annamalai University
RP Anuradha, CV (corresponding author), Annamalai Univ, Dept Biochem & Biotechnol, Fac Sci, Annamalainagar 608002, Tamil Nadu, India.
EM cvaradha@hotmail.com
RI Venkatraman, Anuradha/U-8717-2019
OI Carani Venkatraman, Anuradha/0000-0001-9924-2533
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NR 38
TC 29
Z9 30
U1 0
U2 6
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1351-0002
EI 1743-2928
J9 REDOX REP
JI Redox Rep.
PD OCT
PY 2010
VL 15
IS 5
BP 224
EP 232
DI 10.1179/135100010X12826446921545
PG 9
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 676QR
UT WOS:000283929600005
PM 21062538
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Qi, D
   Nie, XL
   Zhang, JJ
AF Qi, Dan
   Nie, Xiaolu
   Zhang, Jianjun
TI A Systematic Review and Meta-Analysis of the Impacts of Time-Restricted
   Eating on Metabolic Homeostasis
SO ANGIOLOGY
LA English
DT Review; Early Access
DE time-restricted eating; metabolic syndrome; meta-analysis; systemic
   review; metabolic dysfunction
ID CARDIOMETABOLIC HEALTH; SHIFT WORKERS; RESISTANCE; PREVENTION; DISEASES;
   WORKING; MARKERS; STRESS; WEIGHT; MODEL
AB This meta-analysis investigated the effect of time-restricted eating (TRE) as an economical lifestyle intervention for the prevention of metabolic syndrome and improving the related metabolic variables. The Cochrane library, MEDLINE, EMBASE, clinical trials, and other databases were searched for randomized controlled trials (RCTs). We included 22 RCTs (1004 participants, aged 18-75 years, including healthy subjects, prediabetes and overweight patients) designed to evaluate the effect of TRE on metabolic parameters. Body mass index (BMI) (-0.56 kg/m(2), 95% CI: -1.00, -0.13, P < .01), fasting blood glucose (-1.74 mmol/L, 95% CI: -3.34, -0.14, P < .01), and body weight (-0.48 kg, 95% CI: -0.74, -0.22, P < .01) in the TRE intervention group were decreased to varying degrees compared with controls. In contrast, high-density lipoprotein cholesterol (HDL-C) levels were significantly increased in the TRE group compared with the control group (P < .01). The change in waist circumference, blood pressure, triglycerides, low-density lipoprotein cholesterol (LDL-C), and total cholesterol did not vary markedly across the groups. In conclusion, this meta-analysis found a significant reduction in BMI, weight, and fasting glucose, as well as a rise in HDL-C level with TRE compared with control. TRE could be used as an adjuvant treatment for metabolic dysfunctions.
C1 [Qi, Dan] Capital Med Univ, Chaoyang Hosp, Dept Cardiol, Beijing, Peoples R China.
   [Nie, Xiaolu] Capital Med Univ, Childrens Hosp, Beijing, Peoples R China.
   [Zhang, Jianjun] Capital Med Univ, Chaoyang Hosp, Dept Cardiol, Beijing, Peoples R China.
   [Zhang, Jianjun] Capital Med Univ, Chaoyang Hosp, Dept Cardiol, Jiangyuan Rd 5, Beijing 100040, Peoples R China.
C3 Capital Medical University; Capital Medical University; Capital Medical
   University; Capital Medical University
RP Zhang, JJ (corresponding author), Capital Med Univ, Chaoyang Hosp, Dept Cardiol, Jiangyuan Rd 5, Beijing 100040, Peoples R China.
EM zmn0359@VIP.sina.com
RI Zhang, Jianjun/KEJ-3941-2024
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NR 58
TC 1
Z9 1
U1 0
U2 5
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0003-3197
EI 1940-1574
J9 ANGIOLOGY
JI Angiology
PD 2024 JAN 16
PY 2024
DI 10.1177/00033197241228046
EA JAN 2024
PG 14
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA FL2F9
UT WOS:001145873000001
PM 38229272
DA 2025-06-11
ER

PT J
AU Loh, NY
   Rosoff, D
   Noordam, R
   Christodoulides, C
AF Loh, Nellie Y.
   Rosoff, Daniel
   Noordam, Raymond
   Christodoulides, Constantinos
TI Investigating the impact of metabolic syndrome traits on telomere
   length: a Mendelian randomization study
SO OBESITY
LA English
DT Article
ID OXIDATIVE STRESS; ASSOCIATIONS; PREVALENCE; P53
AB ObjectiveObservational studies have reported bidirectional associations between metabolic syndrome (MetS) traits and short leukocyte telomere length (LTL), a TL marker in somatic tissues and a proposed risk factor for age-related degenerative diseases. However, in Mendelian randomization studies, longer LTL has been paradoxically associated with higher MetS risk. This study investigated the hypothesis that shorter LTL might be a consequence of metabolic dysfunction. MethodsThis study undertook univariable and multivariable Mendelian randomization. As instrumental variables for MetS traits, all of the genome-wide significant independent signals identified in genome-wide association studies for anthropometric, glycemic, lipid, and blood pressure traits conducted in European individuals were used. Summary-level data for LTL were obtained from a genome-wide association study conducted in the UK Biobank. ResultsHigher BMI was associated with shorter LTL (& beta; = -0.039, 95% CI: -0.058 to -0.020, p = 5 x 10(-5)) equivalent to 1.70 years of age-related LTL change. In contrast, higher low-density lipoprotein cholesterol was associated with longer LTL (& beta; = 0.022, 95% CI: 0.007 to 0.037, p = 0.003) equivalent to 0.96 years of age-related LTL change. Mechanistically, increased low-grade systemic inflammation, as measured by circulating C-reactive protein, and lower circulating linoleic acid levels might link higher BMI to shorter LTL. ConclusionsOverweight and obesity might promote the development of aging-related degenerative diseases by accelerating telomere shortening.
C1 [Loh, Nellie Y.; Rosoff, Daniel; Christodoulides, Constantinos] Univ Oxford, Oxford Ctr Diabet Endocrinol & Metab, Radcliffe Dept Med, Oxford, England.
   [Rosoff, Daniel] NIAAA, Sect Clin Genom & Expt Therapeut, NIH, Bethesda, MD USA.
   [Noordam, Raymond] Leiden Univ, Med Ctr, Dept Internal Med, Sect Gerontol & Geriatr, Leiden, Netherlands.
   [Christodoulides, Constantinos] Oxford Univ Hosp Natl Hlth Serv Fdn Trust, Natl Inst Hlth Res, Oxford Biomed Res Ctr, Oxford, England.
   [Christodoulides, Constantinos] Churchill Hosp, Oxford Ctr Diabet Endocrinol & Metab, Oxford, England.
C3 University of Oxford; National Institutes of Health (NIH) - USA; NIH
   National Institute on Alcohol Abuse & Alcoholism (NIAAA); Leiden
   University - Excl LUMC; Leiden University; Leiden University Medical
   Center (LUMC); Oxford University Hospitals NHS Foundation Trust;
   University of Oxford; University of Oxford
RP Christodoulides, C (corresponding author), Churchill Hosp, Oxford Ctr Diabet Endocrinol & Metab, Oxford, England.
EM costas.christodoulides@ocdem.ox.ac.uk
RI ; Christodoulides, Constantinos/AGT-9363-2022
OI Noordam, Raymond/0000-0001-7801-809X; Christodoulides,
   Constantinos/0000-0001-5154-0785
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NR 45
TC 9
Z9 9
U1 1
U2 20
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1930-7381
EI 1930-739X
J9 OBESITY
JI Obesity
PD AUG
PY 2023
VL 31
IS 8
BP 2189
EP 2198
DI 10.1002/oby.23810
EA JUL 2023
PG 10
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA N0AT9
UT WOS:001020133300001
PM 37415075
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Doke, M
   Komagamine, Y
   Kanazawa, M
   Iwaki, M
   Suzuki, H
   Miyazaki, Y
   Mizuno, T
   Okayasu, K
   Minakuchi, S
AF Doke, Midori
   Komagamine, Yuriko
   Kanazawa, Manabu
   Iwaki, Maiko
   Suzuki, Hiroyuki
   Miyazaki, Yasunari
   Mizuno, Tetsuya
   Okayasu, Kaori
   Minakuchi, Shunsuke
TI Effect of dental intervention on improvements in metabolic syndrome
   patients: a randomized controlled clinical trial
SO BMC ORAL HEALTH
LA English
DT Article
DE Metabolic syndrome; Obesity; Dental intervention; Periodontal treatment;
   Prosthodontic treatment
ID PERIODONTAL TREATMENT; INSULIN-RESISTANCE; DIABETES-MELLITUS; OXIDATIVE
   STRESS; HEALTH BEHAVIOR; OBESITY; INFLAMMATION; DISEASE
AB BackgroundMetabolic syndrome (MetS), caused by the accumulation of visceral fat, is considered a major cause of cardiovascular disease. This randomized controlled trial aimed to clarify the effect of dental intervention, including prosthodontics and/or periodontal treatment, combined with dietary and exercise guidance on MetS.MethodsIn total, 112 patients who met the Japanese waist circumference criteria of MetS were recruited. The intervention group (ITG) received dental intervention along with dietary and exercise guidance, while the control group (CTG) received dietary and exercise guidance alone. Three outcome measurements were obtained before intervention (BL), 1 month after intervention (1M), and 3 months after intervention (3M).ResultsBody water rate (p=0.043) was significantly higher in ITG than in CTG at 1M. Simultaneously, fasting blood sugar level (p=0.098) tended to be lower in ITG than in CTG. Lean mass (p=0.037) and muscle mass (p=0.035) were significantly higher and body weight (p=0.044) significantly lower in ITG than in CTG at 3M. Body mass index (p=0.052) tended to be lower in ITG than in CTG.ConclusionsDental intervention combined with lifestyle guidance may improve anthropometric status and reduce the risk of MetS.Trial registrationUniversity Hospital Medical Information Network Center Unique UMIN000022753. https://upload.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000026176.
C1 [Doke, Midori; Komagamine, Yuriko; Kanazawa, Manabu; Suzuki, Hiroyuki; Minakuchi, Shunsuke] Tokyo Med & Dent Univ, Grad Sch Med & Dent Sci, Gerodontol & Oral Rehabil, Bunkyo Ku, Tokyo, Japan.
   [Iwaki, Maiko] Tokyo Med & Dent Univ, Grad Sch Med & Dent Sci, Gen Dent, Tokyo, Japan.
   [Miyazaki, Yasunari] Tokyo Med & Dent Univ, Grad Sch Med & Dent Sci, Dept Resp Med, Tokyo, Japan.
   [Mizuno, Tetsuya] Tokyo Med & Dent Univ, Coll Liberal Arts & Sci, Dept Hlth Sci & Phys Educ, Tokyo, Japan.
   [Okayasu, Kaori] Yokohama City Minato Red Cross Hosp, Med Ctr Allerg & Immune Dis, Yokohama, Kanagawa, Japan.
C3 Institute of Science Tokyo; Tokyo Medical & Dental University (TMDU);
   Institute of Science Tokyo; Tokyo Medical & Dental University (TMDU);
   Institute of Science Tokyo; Tokyo Medical & Dental University (TMDU);
   Institute of Science Tokyo; Tokyo Medical & Dental University (TMDU)
RP Komagamine, Y (corresponding author), Tokyo Med & Dent Univ, Grad Sch Med & Dent Sci, Gerodontol & Oral Rehabil, Bunkyo Ku, Tokyo, Japan.
EM y.komagamine.gerd@tmd.ac.jp
RI 学, 金澤/AAC-6829-2021; Iwaki, Maiko/KVK-3489-2024
OI Suzuki, Hiroyuki/0000-0003-0420-9146; Iwaki, Maiko/0000-0001-5326-9482
FU  [16H05521]
FX This study was funded by Grants-in-Aid for Scientific Research
   (KAKENHI)-Scientific Research B 16H05521.
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NR 35
TC 6
Z9 7
U1 0
U2 3
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1472-6831
J9 BMC ORAL HEALTH
JI BMC Oral Health
PD JAN 6
PY 2021
VL 21
IS 1
AR 4
DI 10.1186/s12903-020-01373-3
PG 13
WC Dentistry, Oral Surgery & Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dentistry, Oral Surgery & Medicine
GA PS9TR
UT WOS:000608266600002
PM 33407371
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Luo, J
   Xu, L
   Li, J
   Zhao, SP
AF Luo, Jun
   Xu, Li
   Li, Jiang
   Zhao, Shuiping
TI Nonalcoholic fatty liver disease as a potential risk factor of
   cardiovascular disease
SO EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
LA English
DT Review
DE nonalcoholic fatty liver disease; cardiovascular disease; obesity
ID CORONARY-HEART-DISEASE; GAMMA-GLUTAMYL-TRANSFERASE; INTIMA-MEDIA
   THICKNESS; TERM-FOLLOW-UP; HEPATIC STEATOSIS; METABOLIC-SYNDROME;
   CAROTID ATHEROSCLEROSIS; INSULIN-RESISTANCE; PLASMINOGEN-ACTIVATOR;
   DENSITY-LIPOPROTEIN
AB Nonalcoholic fatty liver disease (NAFLD) is the hepatic component of the metabolic syndrome. The aim of this review is to summarize the available data linking NAFLD with cardiovascular disease (CVD). The following topics are reviewed: (a) the clinical evidence linking NAFLD to increased prevalence of CVD; (b) the relationship between NAFLD (which is diagnosed by liver biopsy, serum liver enzymes, or ultrasonography) and incidence of CVD; (c) the mechanism linking NAFLD to CVD and clinical implication; and (d) the potential impact of NAFLD treatment on cardiac complications. CVD dictates the outcome (or outcomes) in patients with NAFLD more frequently and to a greater extent than does the progression of liver disease. NAFLD patients have a higher risk of all-cause death than the general population, mainly because of CVD or liver-related causes. The biologic mechanism linking NAFLD and CVD might be associated with various factors, involving a complex interaction among insulin resistance, oxidative stress, abnormal adipocytokine profile, endothelial dysfunction, lipid abnormalities, and activation of inflammatory cascade. Lifestyle modifications and pharmacotherapy are helpful to treat patients with NAFLD. NAFLD is likely to be associated with an increased risk of CVD, and raises the possibility that NAFLD may not only be a marker but also an early mediator of CVD. Copyright (C) 2015 Wolters Kluwer Health, Inc. All rights reserved.
C1 [Luo, Jun; Li, Jiang; Zhao, Shuiping] Cent S Univ, Dept Cardiol, Xiangya Hosp 2, Changsha 410011, Hunan, Peoples R China.
   [Xu, Li] Cent S Univ, Dept Chest Med 2, Affiliated Canc Hosp, Changsha 410011, Hunan, Peoples R China.
C3 Central South University; Central South University
RP Zhao, SP (corresponding author), Cent S Univ, Dept Cardiol, Xiangya Hosp 2, Changsha 410011, Hunan, Peoples R China.
EM zhaosp@medmail.com.cn
RI Luo, Jun/JPX-3855-2023
OI Li, Jiang/0000-0003-4904-6635
FU Hunan Provincial Innovation Foundation For Postgraduate [CX2014B104];
   National Natural Science Foundation of China [81370249]; Hunan
   Provincial Natural Science Foundation of China [13JJ3021]
FX This study was supported by Project CX2014B104 of the Hunan Provincial
   Innovation Foundation For Postgraduate, Project 81370249 supported by
   the National Natural Science Foundation of China, and Project 13JJ3021
   supported by the Hunan Provincial Natural Science Foundation of China.
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NR 88
TC 50
Z9 52
U1 2
U2 23
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0954-691X
EI 1473-5687
J9 EUR J GASTROEN HEPAT
JI Eur. J. Gastroenterol. Hepatol.
PD MAR
PY 2015
VL 27
IS 3
BP 193
EP 199
DI 10.1097/MEG.0000000000000254
PG 7
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA CA6FS
UT WOS:000349006000001
PM 25563143
DA 2025-06-11
ER

PT J
AU Yen, CH
   Chen, SJ
   Liu, JT
   Tseng, YF
   Lin, PT
AF Yen, Chi-Hua
   Chen, Shu-Ju
   Liu, Jen-Tzu
   Tseng, Yu-Fen
   Lin, Ping-Ting
TI Effects of Water Extracts of Graptopetalum paraguayense on Blood
   Pressure, Fasting Glucose, and Lipid Profiles of Subjects with Metabolic
   Syndrome
SO BIOMED RESEARCH INTERNATIONAL
LA English
DT Article
ID OXIDATIVE STRESS; ANTIOXIDANT ACTIVITY; WALTHER,E. EXTRACTS;
   DIABETES-MELLITUS; IN-VITRO; PREVALENCE; OBESITY; LIPOPROTEINS;
   HYPERTENSION; PARAOXONASE
AB This study was aimed to investigate the effects of water extracts of Graptopetalum paraguayense (WGP, 4 g/d) on blood pressure, blood glucose level, and lipid profiles in subjects with metabolic syndrome (MS). Participants with MS (n = 54) were randomly assigned to the placebo (n = 28) and WGP groups (n = 26), and the intervention was administered for 12 weeks. Systolic blood pressure (SBP), diastolic blood pressure (DBP), fasting glucose (FG), lipid profiles (total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), and high density lipoprotein (HDL-C)), and antioxidant enzymes activities (catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx)) were measured. Forty-two subjects completed the study (placebo, n = 19; WGP, n = 23). FG, SBP, and LDL-C levels were significantly lower and HDL-C level and antioxidant enzymes activities (CAT and SOD) were significantly higher after WGP supplementation. Blood pressure, FG, and lipid profiles were significantly correlated with antioxidant enzymes activities after supplementation (P < 0.05). The present study demonstrated a significant reduction in blood pressure, blood glucose, and lipid profiles and an increase in antioxidant enzymes activities in subjects with MS after WGP supplementation. Taken together, the antioxidative capacity of W GP might exert a beneficial effect on MS. This trial is registered with ClinicalTrials.gov NCT01463748.
C1 [Yen, Chi-Hua] Chung Shan Med Univ Hosp, Dept Family & Community Med, Taichung 40201, Taiwan.
   [Yen, Chi-Hua] Chung Shan Med Univ, Sch Med, Taichung 40201, Taiwan.
   [Yen, Chi-Hua] Chung Shan Med Univ, Ctr Educ & Res Geriatr & Gerontol, Taichung 40201, Taiwan.
   [Chen, Shu-Ju] Chung Chou Univ Sci & Technol, Dept Hlth Food, Changhua 51003, Taiwan.
   [Liu, Jen-Tzu; Tseng, Yu-Fen; Lin, Ping-Ting] Chung Shan Med Univ, Sch Nutr, Taichung 40201, Taiwan.
   [Lin, Ping-Ting] Chung Shan Med Univ Hosp, Dept Nutr, Taichung 40201, Taiwan.
C3 Chung Shan Medical University; Chung Shan Medical University Hospital;
   Chung Shan Medical University; Chung Shan Medical University; Chung Shan
   Medical University; Chung Shan Medical University; Chung Shan Medical
   University Hospital
RP Lin, PT (corresponding author), Chung Shan Med Univ, Sch Nutr, Taichung 40201, Taiwan.
EM apt810@csmu.edu.tw
RI Stefanadis, Christodoulos/ABH-2232-2020
OI Stefanadis, Christodoulos/0000-0001-5974-6454
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NR 41
TC 10
Z9 10
U1 0
U2 4
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2314-6133
EI 2314-6141
J9 BIOMED RES INT
JI Biomed Res. Int.
PY 2013
VL 2013
AR 809234
DI 10.1155/2013/809234
PG 8
WC Biotechnology & Applied Microbiology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Research & Experimental Medicine
GA 265PP
UT WOS:000327964400001
PM 24371832
OA hybrid, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Cai, DS
AF Cai, Dongsheng
TI NFκB-mediated metabolic inflammation in peripheral tissues versus
   central nervous system
SO CELL CYCLE
LA English
DT Review
DE NF kappa B; obesity; insulin resistance; metabolic syndrome;
   hypothalamus
ID INDUCED INSULIN-RESISTANCE; PROTEIN-KINASE-C; NECROSIS-FACTOR-ALPHA;
   PROOPIOMELANOCORTIN MESSENGER-RNA; ACTIVATED RECEPTOR-BETA/DELTA;
   OXIDATIVE STRESS; SKELETAL-MUSCLE; REACTIVE PROTEIN; LEPTIN RECEPTOR;
   ADIPOSE-TISSUE
AB Obesity, type 2 diabetes, and the associated metabolic syndrome are known as the aggregate products from nutritional excess, and have become huge epidemics and represent public health problems in the developed world. Yet, there exist few successful approaches for the treatment and prevention of these complex diseases, in part because they are not well understood at the molecular levels. Recent research has revealed that many nutrient- and pathogen-sensing systems can be highly integrated, positing the regulatory system of immune response at the mechanistic interface between metabolic regulation and the development of overnutrition-related diseases. The underlying molecular processes have been associated with the basis of how nutritional changes trigger atypical inflammation and how metabolic inflammation affects the signaling and functions of metabolic tissues and cells. In this endeavor, the pro-inflammatory axis consisting of the nuclear transcription factor NF kappa B and its upstream kinase IKK beta has been identified as one critical mediator that is responsible for nutritionally-induced inflammation, and a large body of research has been documented to support the concept that IKK beta/NF kappa B represents a general cause of various metabolic dysfunctions under overnutrition. Here, we comparatively review the tissue-specific programs and actions of IKK beta/NF kappa B in causing and promoting overnutrition-related diseases.
C1 Albert Einstein Coll Med, Dept Mol Pharmacol, Diabet Res Ctr, Bronx, NY 10461 USA.
C3 Yeshiva University; Montefiore Medical Center; Albert Einstein College
   of Medicine
RP Cai, DS (corresponding author), Albert Einstein Coll Med, Dept Mol Pharmacol, Diabet Res Ctr, 1300 Morris Pk Ave, Bronx, NY 10461 USA.
EM dcai@aecom.yu.edu
RI Cai, Dongsheng/CAH-8271-2022
FU National Institute of Health [DK078750]; American Diabetes Association
   [1-07JF-09]
FX The author wishes to thank Cai lab members for the related research.
   Research of author's lab is supported by National Institute of Health
   (DK078750) and American Diabetes Association (1-07JF-09).
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NR 125
TC 68
Z9 75
U1 0
U2 7
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1538-4101
EI 1551-4005
J9 CELL CYCLE
JI Cell Cycle
PD AUG 15
PY 2009
VL 8
IS 16
BP 2542
EP 2548
DI 10.4161/cc.8.16.9386
PG 7
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA 483QY
UT WOS:000268983900019
PM 19633416
OA Bronze
DA 2025-06-11
ER

PT J
AU Katagiri, H
   Yamada, T
   Oka, Y
AF Katagiri, Hideki
   Yamada, Tetsuya
   Oka, Yoshitomo
TI Adiposity and cardiovascular disorders - Disturbance of the regulatory
   system consisting of humoral and neuronal signals
SO CIRCULATION RESEARCH
LA English
DT Review
DE adipocytokines; autonomic nervous system; metabolic syndrome;
   atherosclerosis; hypertension
ID SYMPATHETIC-NERVE ACTIVATION; ANGIOPOIETIN-LIKE PROTEIN-3; INDUCED
   INSULIN-RESISTANCE; VISCERAL FAT ACCUMULATION; C-REACTIVE PROTEIN;
   ENDOTHELIAL-CELLS; PLASMA LEPTIN; NITRIC-OXIDE; ADIPONECTIN ACTS;
   OXIDATIVE STRESS
AB Obesity, a major healthcare issue, is associated with significant cardiovascular morbidities, including hypertension and atherosclerosis. Numerous intensive studies conducted this decade have revealed that adipose tissue is a major endocrine organ that secretes a variety of bioactive substances, termed adipocytokines. Adipocytokine secretion profiles are altered as obesity develops, which may increase the risk of obesity-related cardiovascular disorders. For instance, leptin is upregulated in obese subjects and plays important roles in the pathophysiology of obesity-related atherogenesis through multiple mechanisms, such as its proliferative, proinflammatory, prothrombotic, and prooxidant actions. In contrast, adiponectin, which is downregulated in obese subjects, has protective effects against cardiovascular disorders at various atherogenic stages. In addition to these factors secreted by adipose tissue, neuronal circuits involving autonomic nerves are now being recognized as an important metabolic regulatory system and have thus attracted considerable attentions. Alterations in fat accumulation in intraabdominal organs, such as visceral adipose tissue and the liver, send afferent neuronal signals to the brain, leading to modulation of sympathetic tonus and thereby affecting the vasculature. Moreover, these humoral and neuronal signaling pathways communicate with each other, resulting in cooperative metabolic regulation among tissues/organs throughout the body. Further elucidation of these regulatory systems is anticipated to lead to new approaches to devising therapeutic strategies for the metabolic syndrome.
C1 Tohoku Univ, Grad Sch Med, Ctr Translat & Adv Anim Res, Div Adv Therapeut Metab Dis,Aoba Ku, Sendai, Miyagi 9808575, Japan.
   Tohoku Univ, Grad Sch Med, Div Mol Metab & Diabet, Sendai, Miyagi 9808575, Japan.
C3 Tohoku University; Tohoku University
RP Katagiri, H (corresponding author), Tohoku Univ, Grad Sch Med, Ctr Translat & Adv Anim Res, Div Adv Therapeut Metab Dis,Aoba Ku, 2-1 Seiryo Machi, Sendai, Miyagi 9808575, Japan.
EM katagiri@mail.tains.tohoku.ac.jp
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NR 138
TC 178
Z9 203
U1 0
U2 9
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0009-7330
EI 1524-4571
J9 CIRC RES
JI Circ.Res.
PD JUL 6
PY 2007
VL 101
IS 1
BP 27
EP 39
DI 10.1161/CIRCRESAHA.107.151621
PG 13
WC Cardiac & Cardiovascular Systems; Hematology; Peripheral Vascular
   Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Hematology
GA 186VC
UT WOS:000247805500005
PM 17615379
OA Bronze
DA 2025-06-11
ER

PT J
AU Cave, M
   Deaciuc, I
   Mendez, C
   Song, ZY
   Joshi-Barve, S
   Barve, S
   McClain, C
AF Cave, Matthew
   Deaciuc, Ion
   Mendez, Christian
   Song, Zhenyuan
   Joshi-Barve, Swati
   Barve, Shirish
   McClain, Craig
TI Nonalcoholic fatty liver disease: predisposing factors and the role of
   nutrition
SO JOURNAL OF NUTRITIONAL BIOCHEMISTRY
LA English
DT Review
DE non-alcoholic steatohepatitis; industrial toxins; non-alcoholic fatty
   liver disease
ID TUMOR-NECROSIS-FACTOR; ALANINE AMINOTRANSFERASE ACTIVITY; VITAMIN-E
   TREATMENT; S-ADENOSYLMETHIONINE; INSULIN-RESISTANCE; FACTOR-ALPHA;
   TNF-ALPHA; METHIONINE ADENOSYLTRANSFERASE; METABOLIC SYNDROME; HEPATIC
   STEATOSIS
AB More than 20% of Americans have nonalcoholic fatty liver disease (NAFLD), and this is, by far, the leading cause of abnormal liver enzymes in the United States. Nonalcoholic steatohepatitis (NASH), a more serious form of NAFLD, can proceed to cirrhosis and even hepatocellular carcinoma. These liver diseases represent the hepatic component of the metabolic syndrome, and this spectrum of liver disease represents a major health problem both in the United States and worldwide. Hepatic steatosis is closely linked to nutrition, including obesity, possibly high-fructose corn syrup consumption and consumption of certain types of fats. There are a variety of second insults or "hits" that appear to transform simple steatosis into NASH, with some of these second hits including certain proinflammatory cytokines, oxidative stress and possibly industrial toxins. In certain underdeveloped countries, it appears likely that industrial toxins play a role in NASH, and there is increasing interest in the potential interaction of industrial toxins and nutrients. Moreover, optimal therapy for NAFLD appears to include lifestyle modification with exercise, diet and weight loss. Certain nutrients may also be of benefit. Important areas for future research are the effect(s) of nutritional supplements on NAFLD/NASH and the effects of industrial toxins. Published by Elsevier Inc.
C1 Univ Louisville, Med Ctr, Dept Med, Louisville, KY 40292 USA.
C3 University of Louisville
RP McClain, C (corresponding author), Univ Louisville, Med Ctr, Dept Med, Louisville, KY 40292 USA.
EM craig.mcclain@louisville.edu
FU NIAAA NIH HHS [R37AA010762, R21 AA015611, K01 AA015344-01A1,
   R01AA014371, R01AA010496, R01AA15970] Funding Source: Medline; NIDDK NIH
   HHS [R01DK071765] Funding Source: Medline
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NR 105
TC 220
Z9 250
U1 0
U2 39
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0955-2863
EI 1873-4847
J9 J NUTR BIOCHEM
JI J. Nutr. Biochem.
PD MAR
PY 2007
VL 18
IS 3
BP 184
EP 195
DI 10.1016/j.jnutbio.2006.12.006
PG 12
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA 143MY
UT WOS:000244727700008
PM 17296492
DA 2025-06-11
ER

PT J
AU Jhen, RN
   Wang, PC
   Chang, YM
   Kao, JL
   Wu, ECH
   Shiao, CC
AF Jhen, Rong-Na
   Wang, Ping-Chen
   Chang, Yu-Ming
   Kao, Jsun-Liang
   Wu, Eric Chien-Hwa
   Shiao, Chih-Chung
TI The Clinical Significance and Application of Heart Rate Variability in
   Dialysis Patients: A Narrative Review
SO BIOMEDICINES
LA English
DT Review
DE autonomic nervous system; end-stage kidney disease; heart rate
   variability; dialysis; prediction; prognosis
ID SHORT-TERM; RISK STRATIFICATION; CARDIOVASCULAR-DISEASE; METABOLIC
   SYNDROME; SPECTRAL-ANALYSIS; RENAL-FAILURE; DYSFUNCTION; MORTALITY;
   PREDICTS
AB Autonomic nervous system (ANS) dysfunction is prevalent in end-stage kidney disease (ESKD) patients, carrying significant risks for morbidity and mortality. Heart rate variability (HRV) is a simple and non-invasive method to evaluate ANS functions and predict prognoses in specific patient populations. Since there is a lack of a clear understanding of the clinical significance of HRV in predicting prognoses in ESKD patients, an updated review on this topic is urgently warranted. The clinical significance of HRV in dialysis patients includes its associations with metabolic syndrome, nutritional status, intradialytic hypotension, vascular access failure, major adverse cardiovascular events, and mortality. These findings underscore the essential role of the autonomic reserve, which might denote the elevation of ANS activity as a response to external stimulus. Patients with a higher level of sympathetic activity at the resting stage, but who are unable to adequately elevate their sympathetic activity under stress might be susceptible to a worse outcome in critical circumstances. Further applications of HRV include HRV biofeedback, risk classification, and real-time HRV monitoring. Overall, HRV is an optimal tool for predicting prognoses in dialysis patients. Further study is encouraged in order to gain a clearer understanding of the clinical significance and application of HRV, and thereby enhance the care of ESKD patients.
C1 [Jhen, Rong-Na; Chang, Yu-Ming; Kao, Jsun-Liang; Shiao, Chih-Chung] Camillian St Marys Hosp Luodong, Dept Internal Med, Div Nephrol, 160,Zhongzheng S Rd, Luodong Township 265, Yilan, Taiwan.
   [Wang, Ping-Chen] Camillian St Marys Hosp Luodong, Dept Med Res & Educ, 160,Zhongzheng S Rd, Luodong Township 265, Yilan, Taiwan.
   [Wu, Eric Chien-Hwa] Camillian St Marys Hosp Jiaoxi, Dept Internal Med, Div Nephrol, 129,Sec 4,Jiaoxi R, Jiaoxi Township 262, Yilan, Taiwan.
RP Shiao, CC (corresponding author), Camillian St Marys Hosp Luodong, Dept Internal Med, Div Nephrol, 160,Zhongzheng S Rd, Luodong Township 265, Yilan, Taiwan.
EM wynnazhen@gmail.com; pw279@outlook.com; ynk123.tw@yahoo.com.tw;
   smh01068@smh.org.tw; planetarium0527@gmail.com; chungyy2001@yahoo.com.tw
RI Ren, Yongcheng/AAF-4911-2019; Wu, Eric/B-3101-2013; Shiao,
   Chih-Chung/AAM-2716-2020
OI Chih-Chung Shiao, xiao zhi zhong/0000-0003-2220-7574; Wang,
   Pingchen/0009-0009-5233-7194
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NR 72
TC 2
Z9 2
U1 4
U2 4
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2227-9059
J9 BIOMEDICINES
JI Biomedicines
PD JUL
PY 2024
VL 12
IS 7
AR 1547
DI 10.3390/biomedicines12071547
PG 16
WC Biochemistry & Molecular Biology; Medicine, Research & Experimental;
   Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Research & Experimental Medicine;
   Pharmacology & Pharmacy
GA ZP4G0
UT WOS:001276480600001
PM 39062120
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Kaya, O
   Mermutlu, SI
AF Kaya, Ozge
   Mermutlu, Selda Isik
TI MONOCYTE-TO-HDL CHOLESTEROL RATIO AS A NEW PARAMETER OF SYSTEMIC
   INFLAMMATION AND DISEASE SEVERITY IN TREATMENT-RESISTANT CHRONIC
   SPONTANEOUS URTICARIA
SO JOURNAL OF BASIC AND CLINICAL HEALTH SCIENCES
LA English
DT Article
DE Chronic spontaneous urticaria; C-reactive protein; inflammation;
   metabolic syndrome; monocyte-to-HDL ratio
ID METABOLIC SYNDROME
AB Purpose: Chronic spontaneous urticaria (CSU) is characterized by inflammation and increased oxidative stress in its pathogenesis. The study aims to evaluate new inflammatory markers indicating systemic inflammation in resistant CSU and to determine their relationship with disease activity. Material and Methods: The files of CSU patients and matched healthy volunteers were reviewed and compared in terms of demographics, medical history, clinical features, laboratory parameters, and new inflammatory markers [NLR:neutrophil-lymphocyte ratio, MLR: monocyte-lymphocyte ratio, MHR:monocyte-to-high-density lipoprotein cholesterol (HDL-C)]. Results: Sixty-one CSU patients and 50 healthy controls were evaluated (female: male ratio=1.9:1, mean age=43.97 +/- 14.88 years). The median erythrocyte sedimentation rate, C-reactive protein (CRP), white blood cell, monocyte count, and MHR were higher in the CSU group; in contrast, the mean HDL-C level was lower. The median NLR and MLR were also higher in the CSU group but were not statistically significant. There was a positive correlation between urticaria activity score 7 (UAS7) and MHR and a negative correlation between UAS 7 and HDL-C. MHR was positively correlated with MLR, CRP, and UAS7. Conclusion: MHR might serve as an indicator of inflammation intensity and predisposition to MS in CSU patients. It might also be used as an objective tool for evaluating disease severity and treatment response in CSU
C1 [Kaya, Ozge; Mermutlu, Selda Isik] Canakkale Onsekiz Mart Univ, Fac Med, Dept Dermatol & Venereol Canakkale, Canakkale, Turkiye.
C3 Canakkale Onsekiz Mart University
RP Kaya, O (corresponding author), Canakkale Onsekiz Mart Univ, Fac Med, Dept Dermatol & Venereol Canakkale, Canakkale, Turkiye.
EM ozgetrkz@hotmail.com
RI KAYA, OZGE/GWZ-2582-2022
OI KAYA, OZGE/0000-0001-8062-1664
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NR 16
TC 0
Z9 0
U1 0
U2 1
PU DOKUZ EYLUL UNIV INST HEALTH SCIENCES
PI IZMIR
PA DEPT MEDICAL BIOCHEMISTRY, FAC MEDICINE, DOKUZ EYLUL UNIV, IZMIR, TURKEY
SN 2458-8938
EI 2564-7288
J9 J BASIC CLIN HEALTH
JI J. Basic Clin. Health Sci.
PY 2023
VL 7
IS 1
BP 501
EP 506
DI 10.30621/jbachs.1210134
PG 6
WC Health Care Sciences & Services
WE Emerging Sources Citation Index (ESCI)
SC Health Care Sciences & Services
GA 8U2SH
UT WOS:000929801200009
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Blasio, A
   Izzicupo, P
   Di Baldassarre, A
   Gallina, S
   Bucci, I
   Giuliani, C
   Di Santo, S
   Di Iorio, A
   Ripari, P
   Napolitano, G
AF Di Blasio, Andrea
   Izzicupo, Pascal
   Di Baldassarre, Angela
   Gallina, Sabina
   Bucci, Ines
   Giuliani, Cesidio
   Di Santo, Serena
   Di Iorio, Angelo
   Ripari, Patrizio
   Napolitano, Giorgio
TI Walking training and cortisol to DHEA-S ratio in postmenopause: An
   intervention study
SO WOMEN & HEALTH
LA English
DT Article
DE Cortisol; DHEA-S; postmenopause; walking exercise
ID PHYSICAL-ACTIVITY; METABOLIC SYNDROME; EXERCISE; DEFINITIONS; MENOPAUSE;
   ANDROGENS; MORTALITY; SULFATE; FITNESS; STRESS
AB The literature indicates that the plasma cortisol-to-dehydroepiandrosterone-sulfate (DHEA-S) ratio is a marker of health status after menopause, when a decline in both estrogen and DHEA-S and an increase in cortisol occur. An increase in the cortisol-to-DHEA-S ratio has been positively correlated with metabolic syndrome, all-cause mortality, cancer, and other diseases. The aim of this study was to investigate the effects of a walking program on the plasma cortisol-to-DHEA-S ratio in postmenopausal women. Fifty-one postmenopausal women participated in a 13-week supervised walking program, in the metropolitan area of Pescara (Italy), from June to September 2013. Participants were evaluated in April-May and September-October of the same year. The linear mixed model showed that the variation of the log(10)Cortisol-to-log(10)DHEA-S ratio was associated with the volume of exercise (p=.03). Participants having lower adherence to the walking program did not have a significantly modified log(10)Cortisol or log(10)DHEA-S, while those having the highest adherence had a significant reduction in log(10)Cortisol (p=.016) and a nearly significant increase in log(10)DHEA-S (p=.084). Walking training appeared to reduce the plasma log(10)Cortisol-to-log(10)DHEA-S ratio, although a minimum level of training was necessary to achieve this significant reduction.
C1 [Di Blasio, Andrea; Bucci, Ines; Giuliani, Cesidio; Di Santo, Serena; Napolitano, Giorgio] G dAnnunzio Univ Chieti Pescara, Endocrine Sect, Dept Med & Aging Sci, Chieti, Italy.
   [Izzicupo, Pascal; Di Baldassarre, Angela] G dAnnunzio Univ Chieti Pescara, Human Morphol Sect, Dept Med & Aging Sci, Chieti, Italy.
   [Gallina, Sabina] G dAnnunzio Univ Chieti Pescara, Dept Neurosci & Imaging, Chieti, Italy.
   [Di Iorio, Angelo] G dAnnunzio Univ Chieti Pescara, Dept Med & Aging Sci, Lab Clin Epidemiol & Aging, Chieti, Italy.
   [Ripari, Patrizio] G dAnnunzio Univ Chieti Pescara, Dept Clin & Expt Sci, Chieti, Italy.
C3 G d'Annunzio University of Chieti-Pescara; G d'Annunzio University of
   Chieti-Pescara; G d'Annunzio University of Chieti-Pescara; G d'Annunzio
   University of Chieti-Pescara; G d'Annunzio University of Chieti-Pescara
RP Blasio, A (corresponding author), G dAnnunzio Univ Chieti Pescara, Univ Ctr Sports Med, Dept Med & Aging Sci, Endocrine Sect, Viale Abruzzo 322, I-66013 Chieti, Italy.
EM andiblasio@gmail.com
RI Di Iorio, Angelo/GQO-9254-2022; Ripari, Patrizio/AAH-7553-2021; Di
   Blasio, Andrea/AFY-2050-2022; Di Iorio, Angelo/Q-4458-2017; Bucci,
   Ines/AHD-9644-2022; Di Baldassarre, Angela/D-5402-2014; IZZICUPO,
   PASCAL/K-9699-2018
OI Di Iorio, Angelo/0000-0003-2899-146X; Bucci, Ines/0000-0002-6806-7127;
   Di Baldassarre, Angela/0000-0002-4473-4909; RIPARI,
   Patrizio/0000-0003-3560-2039; IZZICUPO, PASCAL/0000-0001-6944-8995; DI
   BLASIO, Andrea/0000-0002-4084-3147
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   [No title captured]
NR 41
TC 10
Z9 11
U1 0
U2 12
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 0363-0242
EI 1541-0331
J9 WOMEN HEALTH
JI Women Health
PY 2018
VL 58
IS 4
BP 387
EP 402
DI 10.1080/03630242.2017.1310168
PG 16
WC Public, Environmental & Occupational Health; Women's Studies
WE Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; Women's Studies
GA GA3DD
UT WOS:000428207500002
PM 28328386
DA 2025-06-11
ER

PT J
AU Cobbold, JFL
   Anstee, QM
   Taylor-Robinson, SD
AF Cobbold, Jeremy F. L.
   Anstee, Quentin M.
   Taylor-Robinson, Simon D.
TI The importance of fatty liver disease in clinical practice
SO PROCEEDINGS OF THE NUTRITION SOCIETY
LA English
DT Article
DE Hepatic steatosis; Non-alcoholic fatty liver disease; Non-alcoholic
   steatohepatitis; Insulin resistance; Hepatitis; Diabetes mellitus
ID HEPATIC TRIGLYCERIDE CONTENT; NONALCOHOLIC STEATOHEPATITIS;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; CONTROLLED-TRIAL; OBESE MICE;
   STEATOSIS; FIBROSIS; PLACEBO; NAFLD
AB The worldwide obesity epidemic over the last 20 years has led to a dramatic increase in the prevalence of non-alcoholic fatty liver disease, the hepatic manifestation of the metabolic syndrome. Estimates of prevalence vary depending on the population studied and the methods used to assess hepatic fat content, but are commonly quoted as between 10 and 30% of the adults in the Western hemisphere. Fatty liver develops when fatty acid uptake and synthesis in the liver exceeds fatty acid oxidation and export as TAG. Studies of pathogenesis point to insulin resistance, lipotoxicity, oxidative stress and chronic inflammation being central to the development and progression of the disease. A proportion of individuals with fatty liver develop progressive disease, though large prospective longitudinal studies are lacking. Nevertheless, fatty liver is associated with increased all-cause and liver-related mortality compared with the general population. Management of fatty liver centres around lifestyle and dietary measures to induce controlled and sustained weight loss. Management of cardiovascular risk factors aims to reduce mortality, while certain dietary interventions have been shown to reduce steatosis and inflammation. Specific pharmacological treatments also show promise, but their use is not widespread. A multi-system and multi-disciplinary approach to the management of this disorder is proposed.
C1 [Cobbold, Jeremy F. L.; Anstee, Quentin M.; Taylor-Robinson, Simon D.] Univ London Imperial Coll Sci Technol & Med, Hepatol & Gastroenterol Sect, Div Diabet Endocrinol & Metab, Dept Med, London W2 1NY, England.
C3 Imperial College London
RP Cobbold, JFL (corresponding author), Univ London Imperial Coll Sci Technol & Med, Hepatol & Gastroenterol Sect, Div Diabet Endocrinol & Metab, Dept Med, St Marys Hosp Campus,10th Floor,QEQM Bldg,Praed S, London W2 1NY, England.
EM j.cobbold@imperial.ac.uk
RI Anstee, Quentin M./L-2981-2013
OI Anstee, Quentin M./0000-0002-9518-0088
FU Medical Research Council; Wellcome Trust; MRC [G84/6233] Funding Source:
   UKRI
FX J. F. L. C. is a Walport Clinical Lecturer at Imperial College London.
   Q. M. A. and S. T. R. are Imperial College/NIHR Biomedical Research
   Centre investigators and hold grants from the Medical Research Council
   and the Wellcome Trust. All authors are grateful to the NIHR Biomedical
   Facility at Imperial College London for infrastructure support. The
   authors declare no conflict of interest. J. F. L. C., Q. M. A. and S. D.
   T. R. wrote the manuscript and approved the final version.
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NR 71
TC 8
Z9 9
U1 0
U2 3
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0029-6651
EI 1475-2719
J9 P NUTR SOC
JI Proc. Nutr. Soc.
PD NOV
PY 2010
VL 69
IS 4
BP 518
EP 527
DI 10.1017/S0029665110001916
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 678BY
UT WOS:000284045000008
PM 20569523
OA Bronze
DA 2025-06-11
ER

PT J
AU Méndez-Sánchez, N
   Bahena-Aponte, J
   Chávez-Tapia, NC
   Motola-Kuba, D
   Sánchez-Lara, K
   Ponciano-Radríguez, G
   Ramos, MH
   Uribe, M
AF Méndez-Sánchez, N
   Bahena-Aponte, J
   Chávez-Tapia, NC
   Motola-Kuba, D
   Sánchez-Lara, K
   Ponciano-Radríguez, G
   Ramos, MH
   Uribe, M
TI Strong association between gallstones and cardiovascular disease
SO AMERICAN JOURNAL OF GASTROENTEROLOGY
LA English
DT Article
ID CORONARY-HEART-DISEASE; GALLBLADDER-DISEASE; SYMPTOMATIC GALLSTONES;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; RISK-FACTORS; CHOLESTEROL;
   POLYMORPHISM; WEIGHT; PLASMA
AB BACKGROUND AND AIM: Obesity is closely associated with the increased morbidity and mortality of many common diseases in the Western world, including coronary heart disease (CHD) and gallstone diseases (GD). We have investigated the association between GD and CHD in a cross-sectional study.
   METHODS AND RESULTS: Subjects who had gallstones visible by ultrasound were considered as cases and subjects negative for gallstones were classified as controls. Positive CHD was defined when the stress test was positive. Body mass index (BMI), waist circumference, blood pressure, serum lipid concentrations, and insulin resistance were measured. The association was estimated by odds ratios using logistic regression models adjusted for confounders. Four hundred and seventy-three subjects (292 males and 181 females) were included, comprising 354 controls and 119 cases. Subjects with GD had higher prevalence of CHD (15.96%) than controls (4.52%) (p < 0.0001). In univariate unconditional logistic regression analysis CHD, BMI >= 30 kg/m(2), waist circumference, high blood pressure, and HOMA-IR > 2.5 were the most important risk factors for GD. In multivariate analysis (adjusted for age and gender, and BMI) the risk for GD in subjects with CHD was higher (OR 2.84, 95% CI: 1.33-6.07, p < 0.007).
   CONCLUSIONS: Subjects with CHD have an increased risk to have GD, both diseases are strongly associated and the main characteristics of these subjects are those frequently involved as part of the metabolic syndrome.
C1 Med Clin & Fdn, Dept Biomed Res, Mexico City, DF, Mexico.
   Med Clin & Fdn, Dept Gastroenterol, Mexico City, DF, Mexico.
   Med Clin & Fdn, Liver Unit, Mexico City, DF, Mexico.
RP Med Clin & Fdn, Dept Biomed Res, Puente de Piedra 150,Col Toriello Guerra, Mexico City, DF, Mexico.
OI Chavez-Tapia, Norberto/0000-0002-7451-3306; Uribe,
   Misael/0000-0002-6514-7869
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U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0002-9270
EI 1572-0241
J9 AM J GASTROENTEROL
JI Am. J. Gastroenterol.
PD APR
PY 2005
VL 100
IS 4
BP 827
EP 830
DI 10.1111/j.1572-0241.2005.41214.x
PG 4
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 907LU
UT WOS:000227720400018
PM 15784027
DA 2025-06-11
ER

PT J
AU Ram, CVS
AF Ram, C. Venkata S.
TI Therapeutic Usefulness of a Novel Calcium Channel Blocker Azelnidipine
   in the Treatment of Hypertension: A Narrative Review
SO CARDIOLOGY AND THERAPY
LA English
DT Review
DE Antihypertensive agents; Azelnidipine; Calcium channel blockers; Chronic
   renal insufficiency; Diabetes mellitus; Hypertension; India; Metabolic
   syndrome
ID LEFT-VENTRICULAR MASS; SERUM URIC-ACID; BLOOD-PRESSURE; OXIDATIVE
   STRESS; AMLODIPINE; CS-905; SYSTEM; CILNIDIPINE; OLMESARTAN; DIABETICS
AB The prevalence of hypertension and comorbidities such as metabolic syndrome, diabetes mellitus, and chronic kidney disease in India is alarmingly high. Amlodipine, an older-generation calcium channel blocker (CCB), is currently the gold standard for hypertension management in India. However, it has several disadvantages, including reflex tachycardia and pedal edema. Therefore, an effective antihypertensive agent that does not cause these adverse effects and provides end-organ protection is required for the holistic management of hypertension in the country. Azelnidipine is a new-generation CCB that has recently been approved for the treatment of hypertension in India. This review provides an overview of the utility of azelnidipine for hypertension control, including comparisons with traditional CCBs such as amlodipine. It discusses the key antihypertensive effects of azelnidipine as well as its advantages in the prevention of tachycardia and associated complications. In addition, this review highlights the extensive cardio- and renoprotective activities of azelnidipine, including its effects on systolic and diastolic function and urinary albumin excretion. Overall, this substantial body of evidence supports the use of azelnidipine for the treatment of hypertension, especially in India. It suggests that the adoption of azelnidipine as the new gold standard CCB could help India battle its hypertension epidemic.
C1 [Ram, C. Venkata S.] Apollo Inst Blood Pressure Management & Apollo Bl, Hyderabad, India.
   [Ram, C. Venkata S.] Apollo Hosp & Apollo Med Coll, Jubilee Hills, Hyderabad 500033, Telangana, India.
   [Ram, C. Venkata S.] Univ Texas Southwestern Med Ctr Dallas, Dallas, TX 75390 USA.
   [Ram, C. Venkata S.] Macquarie Univ, Fac Med & Hlth Sci, Sydney, NSW, Australia.
C3 University of Texas System; University of Texas Southwestern Medical
   Center Dallas; Macquarie University
RP Ram, CVS (corresponding author), Apollo Inst Blood Pressure Management & Apollo Bl, Hyderabad, India.; Ram, CVS (corresponding author), Apollo Hosp & Apollo Med Coll, Jubilee Hills, Hyderabad 500033, Telangana, India.; Ram, CVS (corresponding author), Univ Texas Southwestern Med Ctr Dallas, Dallas, TX 75390 USA.; Ram, CVS (corresponding author), Macquarie Univ, Fac Med & Hlth Sci, Sydney, NSW, Australia.
EM drram_v@apollohospitals.com
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NR 79
TC 10
Z9 10
U1 1
U2 8
PU SPRINGER LONDON LTD
PI LONDON
PA 236 GRAYS INN RD, 6TH FLOOR, LONDON WC1X 8HL, ENGLAND
SN 2193-8261
EI 2193-6544
J9 CARDIOL THER
JI Cardiol. Ther.
PD DEC
PY 2022
VL 11
IS 4
BP 473
EP 489
DI 10.1007/s40119-022-00276-4
EA AUG 2022
PG 17
WC Cardiac & Cardiovascular Systems
WE Emerging Sources Citation Index (ESCI)
SC Cardiovascular System & Cardiology
GA 6C4QD
UT WOS:000840581200001
PM 35969319
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Ramadori, P
   Kroy, D
   Streetz, KL
AF Ramadori, Pierluigi
   Kroy, Daniela
   Streetz, Konrad L.
TI Immunoregulation by lipids during the development of non-alcoholic
   steatohepatitis
SO HEPATOBILIARY SURGERY AND NUTRITION
LA English
DT Review
DE Hepatocyte; free fatty acids (FFA); lipotoxicity; toll like receptors
   (TLRs); lymphocytes
ID FATTY LIVER-DISEASE; ENDOPLASMIC-RETICULUM STRESS;
   PROLIFERATOR-ACTIVATED RECEPTORS; NLRP3 INFLAMMASOME ACTIVATION; INDUCED
   INSULIN-RESISTANCE; ACID-INDUCED LIPOTOXICITY; HEPATIC STELLATE CELLS;
   NF-KAPPA-B; METABOLIC SYNDROME; FREE-CHOLESTEROL
AB Non-alcoholic fatty liver disease (NAFLD) represents the most common liver disorder in western countries and it is commonly associated with obesity and progression of the metabolic syndrome. Comprehending a wide spectrum of pathologic features, it is currently well recognized that a key point for the integrity of hepatocyte functionality in NAFLD is the progression from simple steatosis to non-alcoholic steatohepatitis (NASH). Indeed, activation of the innate immune system in response to hepatic metabolic stresses represents a central process that determines the evolution and the reversibility of liver damage. Despite of the burden of studies published in recent years, it is still intriguingly unclear how accumulation of lipids in hepatocytes triggers the activation of the inflammatory response leading to the recruitment of infiltrating cells of extra-hepatic origins. In this review we offer a general view on recent advances pointing out how different classes of lipids are able to specifically affect hepatocytes functionality and survival, thus differently influencing the organization of the hepatic immune response. On the other hand, we gathered recent studies intending to illustrate the basic mechanisms through which several non-parenchymal hepatic and extra-hepatic cell populations get activated in response to lipids. Finally, we indicate latter findings proposing how the immune system majorly contributes to the progression of NASH.
C1 [Ramadori, Pierluigi; Kroy, Daniela; Streetz, Konrad L.] RWTH Univ Hosp, Dept Internal Med 3, Pauwelsstr 30, D-52074 Aachen, Germany.
C3 RWTH Aachen University; RWTH Aachen University Hospital
RP Streetz, KL (corresponding author), RWTH Univ Hosp, Dept Internal Med 3, Pauwelsstr 30, D-52074 Aachen, Germany.
EM kstreetz@ukaachen.de
RI Ramadori, Pierluigi/AAZ-7533-2021
FU Deutsche Forschungsgemeinschaft (DFG) [SFB TRR57 p22]
FX This work is supported by a grant (SFB TRR57 p22) of the Deutsche
   Forschungsgemeinschaft (DFG).
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NR 97
TC 28
Z9 29
U1 0
U2 8
PU AME PUBLISHING COMPANY
PI SHATIN
PA FLAT-RM C 16F, KINGS WING PLAZA 1, NO 3 KWAN ST, SHATIN, HONG KONG
   00000, PEOPLES R CHINA
SN 2304-3881
EI 2304-389X
J9 HEPATOBIL SURG NUTR
JI Hepatobil. Surg. Nutr.
PD FEB
PY 2015
VL 4
IS 1
BP 11
EP 23
DI 10.3978/j.issn.2304-3881.2015.01.02
PN 2
PG 13
WC Gastroenterology & Hepatology; Nutrition & Dietetics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Nutrition & Dietetics; Surgery
GA V70LZ
UT WOS:000211509400005
PM 25713801
DA 2025-06-11
ER

PT J
AU Lu, Y
   Yang, XY
   Kuang, Q
   Wu, Y
   Tan, X
   Lan, JZ
   Qiang, Z
   Feng, T
AF Lu, Yang
   Yang, Xinyue
   Kuang, Qin
   Wu, Yong
   Tan, Xin
   Lan, Jizhong
   Qiang, Zhe
   Feng, Tao
TI HBx induced upregulation of FATP2 promotes the development of hepatic
   lipid accumulation
SO EXPERIMENTAL CELL RESEARCH
LA English
DT Article
DE Hepatitis B virus X protein; Fatty acid transport protein 2; Lipid
   accumulation; Oxidative stress; Inflammation
ID VIRUS-X PROTEIN; OXIDATIVE STRESS; METABOLIC SYNDROME; EXPRESSION;
   STEATOSIS; GAMMA; TRANSCRIPTION; INFLAMMATION; ACTIVATION; FIBROSIS
AB The hepatitis B Virus X (HBx) protein plays a crucial role in the HBV-induced hepatic steatosis. Fatty acid transport protein 2 (FATP2) is a key protein that is involved in hepatic lipogenesis, and it was found to be highly expressed in various metabolic diseases. However, Whether FATP2 is a key factor in the pathogenesis of HBxinduced hepatic steatosis remains unclear. In this study, we found that FATP2 was up-regulated by HBx in vitro and in vivo and participated in HBx-induced hepatic lipid accumulation. Treatment of HBx-expressing cell lines and mice with FATP2 inhibitor (FATP2i) lipofermata ameliorated HBx-induced lipid accumulation and reduced oxidative stress and inflammation caused by lipid accumulation. Moreover, the liver injury of mouse was restored after FATP2i treatment. In summary, our results reveal that FATP2 is a key driver factor for HBx-induced hepatic lipid accumulation, and inhibition of FATP2 can ameliorates lipid accumulation caused by HBx. This study provides new insights into the mechanism of HBV-induced hepatic steatosis.
C1 [Lu, Yang; Yang, Xinyue; Kuang, Qin; Wu, Yong; Tan, Xin; Lan, Jizhong; Qiang, Zhe; Feng, Tao] Chongqing Med Univ, Coll Pharm, Chongqing 400016, Peoples R China.
   [Lu, Yang; Yang, Xinyue; Kuang, Qin; Wu, Yong; Tan, Xin; Lan, Jizhong] Chongqing Med Univ, Key Lab Biochem & Mol Pharmacol Chongqing, Chongqing 400016, Peoples R China.
   [Feng, Tao] Chongqing Med Univ, Mol Med & Canc Res Ctr, Chongqing 400016, Peoples R China.
   [Qiang, Zhe] Chongqing Acad Chinese Mat Med, Chongqing 400065, Peoples R China.
C3 Chongqing Medical University; Chongqing Medical University; Chongqing
   Medical University
RP Qiang, Z; Feng, T (corresponding author), Chongqing Med Univ, Coll Pharm, Chongqing 400016, Peoples R China.
EM qz@cqacmm.com; fengtao@cqmu.edu.cn
RI zhe, qiang/N-8996-2017
OI zhe, qiang/0000-0002-3673-5258
FU National Natural Science foundation of China [81071770]; Chongqing
   Graduate Scientific Research Innovation project [CYS21238]; Chongqing
   Fundamental Research Funds [jbky20210001]
FX This work was supported by National Natural Science foundation of China
   [grant number 81071770], Chongqing Graduate Scientific Research
   Innovation project [grant number CYS21238] and Chongqing Fundamental
   Research Funds [grant number jbky20210001].
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NR 49
TC 5
Z9 5
U1 2
U2 12
PU ELSEVIER INC
PI SAN DIEGO
PA 525 B STREET, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0014-4827
EI 1090-2422
J9 EXP CELL RES
JI Exp. Cell Res.
PD SEP 1
PY 2023
VL 430
IS 1
AR 113721
DI 10.1016/j.yexcr.2023.113721
EA JUL 2023
PG 13
WC Oncology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Cell Biology
GA P0BQ4
UT WOS:001047382700001
PM 37437769
OA hybrid
DA 2025-06-11
ER

PT J
AU Estadella, D
   do Nascimento, CMDO
   Oyama, LM
   Ribeiro, EB
   Dâmaso, AR
   de Piano, A
AF Estadella, Debora
   da Penha Oller do Nascimento, Claudia M.
   Oyama, Lila M.
   Ribeiro, Eliane B.
   Damaso, Ana R.
   de Piano, Aline
TI Lipotoxicity: Effects of Dietary Saturated and Transfatty Acids
SO MEDIATORS OF INFLAMMATION
LA English
DT Review
ID NONALCOHOLIC FATTY LIVER; ENDOPLASMIC-RETICULUM STRESS; UNFOLDED PROTEIN
   RESPONSE; INDUCED INSULIN-RESISTANCE; WHITE ADIPOSE-TISSUE; OXIDATIVE
   STRESS; GUT MICROBIOTA; OBESE ADOLESCENTS; METABOLIC SYNDROME;
   HYDROGENATED FAT
AB The ingestion of excessive amounts of saturated fatty acids (SFAs) and transfatty acids (TFAs) is considered to be a risk factor for cardiovascular diseases, insulin resistance, dyslipidemia, and obesity. The focus of this paper was to elucidate the influence of dietary SFA and TFA intake on the promotion of lipotoxicity to the liver and cardiovascular, endothelial, and gut microbiota systems, as well as on insulin resistance and endoplasmic reticulum stress. The saturated and transfatty acids favor a proinflammatory state leading to insulin resistance. These fatty acids can be involved in several inflammatory pathways, contributing to disease progression in chronic inflammation, autoimmunity, allergy, cancer, atherosclerosis, hypertension, and heart hypertrophy as well as other metabolic and degenerative diseases. As a consequence, lipotoxicity may occur in several target organs by direct effects, represented by inflammation pathways, and through indirect effects, including an important alteration in the gut microbiota associated with endotoxemia. Interactions between these pathways may perpetuate a feedback process that exacerbates an inflammatory state. The importance of lifestyle modification, including an improved diet, is recommended as a strategy for treatment of these diseases.
C1 [Estadella, Debora; da Penha Oller do Nascimento, Claudia M.; Oyama, Lila M.; Ribeiro, Eliane B.; de Piano, Aline] Univ Fed Sao Paulo UNIFESP, EPM, Disciplina Fisiol Nutr, Programa Posgrad Nutr, BR-04023060 Sao Paulo, Brazil.
   [Damaso, Ana R.] UNIFESP, Dept Biociencias, BR-11060001 Santos, SP, Brazil.
C3 Universidade Federal de Sao Paulo (UNIFESP); Universidade Federal de Sao
   Paulo (UNIFESP)
RP Estadella, D (corresponding author), Univ Fed Sao Paulo UNIFESP, EPM, Disciplina Fisiol Nutr, Programa Posgrad Nutr, Rua Botucatu,862 Edificio Ciencias Biomed,2 Andar, BR-04023060 Sao Paulo, Brazil.
EM estadella.debora@gmail.com
RI Dâmaso, Ana/AAT-6058-2021; Oyama, Lila/B-7609-2012; do Nascimento,
   Claudia/T-4151-2019; Ribeiro, Eliane/C-8124-2012; de Piano,
   Aline/J-8334-2016; Estadella, Debora/G-5817-2012
OI de Piano, Aline/0000-0001-6433-0816; Estadella,
   Debora/0000-0001-9853-3662
FU FAPESP [2010/20079-2]; CAPES [007419/2011-21]; CNPq [161433/2011-1];
   Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
   [10/20079-2] Funding Source: FAPESP
FX The authors gratefully acknowledge all agencies which supported this
   work: FAPESP (2010/20079-2), CAPES (007419/2011-21), and CNPq
   (161433/2011-1).
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NR 108
TC 136
Z9 151
U1 0
U2 20
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 0962-9351
EI 1466-1861
J9 MEDIAT INFLAMM
JI Mediat. Inflamm.
PY 2013
VL 2013
AR 137579
DI 10.1155/2013/137579
PG 13
WC Cell Biology; Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Immunology
GA 085AP
UT WOS:000314583300001
PM 23509418
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Covelli, MM
   Wood, CE
   Yarandi, HN
AF Covelli, Maureen McCormick
   Wood, Charles E.
   Yarandi, Hossein N.
TI The association of low birth weight and physiological risk factors of
   hypertension in African American adolescents
SO JOURNAL OF CARDIOVASCULAR NURSING
LA English
DT Article
DE blood pressure; cortisol; hypertension; low birth weight
ID BLOOD-PRESSURE; FETAL ORIGINS; SALIVARY CORTISOL; ADULT HYPERTENSION;
   METABOLIC SYNDROME; YOUNG-ADULTS; STRESS; REACTIVITY; CHILDHOOD;
   PREDICTOR
AB Low birth weight (LBW) has been associated with increased blood pressure and the development of cardiovascular disease including hypertension. Elevated blood pressure, cortisol, and hyperresponsiveness during physiologic stress may function as hypertension biological markers. We examined the association of blood pressure and cortisol levels during induced physiologic stress with LBW in an African American adolescent population (n = 106). Methods and Results: Birth weight was obtained from parents. Blood pressure and cortisol levels were measured at rest and in response to an induced physiological stressor. Compared with normal birth weight group (n = 73), the LBW group (n = 33) demonstrated elevated (+4 mm Hg) diastolic pressure (P = .002) and cortisol hyperresponsiveness (P = .05). Seventy-nine percent of LBW adolescents had elevated blood pressure and/or cardiovascular reactivity (P = .04), and 39% had elevated blood pressures. Conclusions: Low birth weight African American adolescents demonstrated physiological risk factors for hypertension, and these findings add support to the association between LBW and the development of hypertension.
C1 Univ Cent Florida, Coll Nursing Orlando, Orlando, FL 32816 USA.
   Univ Florida, Coll Med, Dept Physiol & Funct Genom, Gainesville, FL USA.
   Wayne State Univ, Ctr Hlth Res, Detroit, MI USA.
C3 State University System of Florida; University of Central Florida; State
   University System of Florida; University of Florida; Wayne State
   University
RP Covelli, MM (corresponding author), 447 Stonewood Lane, Maitland, FL 32751 USA.
EM covelli@mail.ucf.edu
RI Wood, Charles/L-2758-2015
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NR 48
TC 6
Z9 6
U1 0
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0889-4655
EI 1550-5049
J9 J CARDIOVASC NURS
JI J. Cardiovasc. Nurs.
PD NOV-DEC
PY 2007
VL 22
IS 6
BP 440
EP 447
DI 10.1097/01.JCN.0000297380.06379.d0
PG 8
WC Cardiac & Cardiovascular Systems; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Cardiovascular System & Cardiology; Nursing
GA 230BK
UT WOS:000250850100010
PM 18090182
DA 2025-06-11
ER

PT J
AU Boake, M
   Mash, R
AF Boake, Megan
   Mash, Robert
TI Diabetes in the Western Cape, South Africa: A secondary analysis of the
   diabetes cascade database 2015-2020
SO PRIMARY CARE DIABETES
LA English
DT Article
DE Diabetes; Primary care; Diabetes complications; Demographics; Glycaemic
   control; Chronic kidney failure; Co-morbidity
ID METABOLIC SYNDROME; GLYCEMIC CONTROL; PRIMARY-CARE; MELLITUS; HEALTH;
   PREVALENCE; AGE
AB Aim: The aim was to describe the demographics, comorbidities and outcomes of care for patients with diabetes at primary care facilities in the Western Cape, South Africa, between 2015 and 2020.
   Methods: This was a secondary analysis of the diabetes cascade database.
   Results: The database included 116726 patients with mean age of 61.4 years and 63.8 % were female. The mean age at death was 66.0 years. Co-morbidities included hypertension (69.5 %), mental health disorders (16.2 %), HIV (6.4 %) and previous TB (8.2 %). Sixty-three percent had at least one previous hospital admission and 20.2 % of all admissions were attributed to cardiovascular diseases. Coronavirus was the third highest reason for admission over a 10-year period. Up to 70% were not receiving an annual HbA1c test. The mean value for the last HBA1c taken was 9.0%. Three-quarters (75.5 %) of patients had poor glycaemic control (HbA1c >7 %) and a third (33.7 %) were very poorly controlled (HbA1c>10 %). Glycaemic control was significantly different between urban sub-districts and rural areas. Renal disease was prevalent in 25.5 %.
   Conclusion: Diabetes was poorly controlled with high morbidity and mortality. There was poor compliance with guidelines for HbA1c and eGFR measurement. At least 7% of diabetic patients were being admitted for complications annually.
C1 [Boake, Megan; Mash, Robert] Stellenbosch Univ, Div Family Med & Primary Care, Box241, ZA-8000 Cape Town, South Africa.
C3 Stellenbosch University
RP Mash, R (corresponding author), Stellenbosch Univ, Div Family Med & Primary Care, Box241, ZA-8000 Cape Town, South Africa.
EM rm@sun.ac.za
RI Mash, Robert/KLZ-1179-2024
CR [Anonymous], 2021, Inaugural South African Diabetes Summit 2021
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NR 44
TC 10
Z9 10
U1 0
U2 1
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 1751-9918
EI 1878-0210
J9 PRIM CARE DIABETES
JI Prim. Care Diabetes
PD AUG
PY 2022
VL 16
IS 4
BP 555
EP 561
DI 10.1016/j.pcd.2022.05.011
EA JUL 2022
PG 7
WC Endocrinology & Metabolism; Primary Health Care
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; General & Internal Medicine
GA 5F2LR
UT WOS:000866152000014
PM 35672227
DA 2025-06-11
ER

PT J
AU Johnson, RJ
   Bakris, GL
   Borghi, C
   Chonchol, MB
   Feldman, D
   Lanaspa, MA
   Merriman, TR
   Moe, OW
   Mount, DB
   Lozada, LGS
   Stahl, E
   Weiner, DE
   Chertow, GM
AF Johnson, Richard J.
   Bakris, George L.
   Borghi, Claudio
   Chonchol, Michel B.
   Feldman, David
   Lanaspa, Miguel A.
   Merriman, Tony R.
   Moe, Orson W.
   Mount, David B.
   Sanchez Lozada, Laura Gabriella
   Stahl, Eli
   Weiner, Daniel E.
   Chertow, Glenn M.
TI Hyperuricemia, Acute and Chronic Kidney Disease, Hypertension, and
   Cardiovascular Disease: Report of a Scientific Workshop Organized by the
   National Kidney Foundation
SO AMERICAN JOURNAL OF KIDNEY DISEASES
LA English
DT Article
ID SERUM URIC-ACID; MENDELIAN RANDOMIZATION ANALYSIS;
   MUSCLE-CELL-PROLIFERATION; SLC2A9 GENETIC-VARIATION; GENOME-WIDE
   ASSOCIATION; CORONARY-HEART-DISEASE; URATE-ANION EXCHANGER;
   BLOOD-PRESSURE; METABOLIC SYNDROME; OXIDATIVE STRESS
AB Urate is a cause of gout, kidney stones, and acute kidney injury from tumor lysis syndrome, but its relationship to kidney disease, cardiovascular disease, and diabetes remains controversial. A scientific workshop organized by the National Kidney Foundation was held in September 2016 to review current evidence. Cell culture studies and animal models suggest that elevated serum urate concentrations can contribute to kidney disease, hypertension, and metabolic syndrome. Epidemiologic evidence also supports elevated serum urate concentrations as a risk factor for the development of kidney disease, hypertension, and diabetes, but differences in methodologies and inpacts on serum urate concentrations by even subtle changes in kidney function render conclusions uncertain. Mendelian randomization studies generally do not support a causal role of serum urate in kidney disease, hypertension, or diabetes, although interpretation is complicated by nonhomogeneous populations, a failure to consider environmental interactions, and a lack of understanding of how the genetic polymorphisms affect biological mechanisms related to urate. Although several small clinical trials suggest benefits of urate-lowering therapies on kidney function, blood pressure, and insulin resistance, others have been negative, with many trials having design limitations and insufficient power. Thus, whether uric acid has a causal role in kidney and cardiovascular diseases requires further study.
C1 [Johnson, Richard J.; Chonchol, Michel B.; Lanaspa, Miguel A.] Univ Colorado, Denver, CO USA.
   [Bakris, George L.] Univ Chicago Med, Chicago, IL USA.
   [Borghi, Claudio] Univ Bologna, Bologna, Italy.
   [Feldman, David] Natl Kidney Fdn, New York, NY USA.
   [Merriman, Tony R.] Univ Otago, Dunedin, New Zealand.
   [Moe, Orson W.] Univ Texas Southwestern Med Ctr Dallas, Dallas, TX 75390 USA.
   [Mount, David B.] Harvard Med Sch, Brigham & Womens Hosp, Boston, MA USA.
   [Sanchez Lozada, Laura Gabriella] Inst Nacl Cardiol, Mexico City, DF, Mexico.
   [Stahl, Eli] Mt Sinai Sch Med, New York, NY USA.
   [Weiner, Daniel E.] Tufts Med Ctr, Boston, MA USA.
   [Chertow, Glenn M.] Stanford Univ, Stanford, CA 94305 USA.
C3 University of Colorado System; University of Colorado Denver; University
   of Chicago; University of Bologna; University of Otago; University of
   Texas System; University of Texas Southwestern Medical Center Dallas;
   Harvard University; Harvard Medical School; Harvard University Medical
   Affiliates; Brigham & Women's Hospital; National Institute of Cardiology
   - Mexico; Icahn School of Medicine at Mount Sinai; Tufts Medical Center;
   Stanford University
RP Chertow, GM (corresponding author), Stanford Univ, Sch Med, 1070 Arastradero Rd,Ste 313, Palo Alto, CA 94304 USA.
EM gchertow@stanford.edu
RI Lanaspa, Miguel/AAO-4971-2020; Bakris, George/AFC-1168-2022;
   Sanchez-Lozada, Laura/AAS-2104-2021
OI Sanchez-Lozada, Laura-Gabriela/0000-0003-0348-9617; Weiner,
   Daniel/0000-0002-8775-394X; Chertow, Glenn/0000-0002-7599-0534
FU Danone Research; Kibow Biotech, Inc; Astra Zeneca; Ardea Biosciences;
   Ironwood Pharmaceuticals
FX Dr Johnson is an inventor on patents related to lowering uric acid as it
   relates to BP, insulin resistance, and diabetic kidney disease and has
   equity in XORT Therapeutics, Inc and Colorado Research Partners LLC,
   which are startup companies interested in developing novel xanthine
   oxidase inhibitors and fructokinase inhibitors, respectively. Dr Johnson
   has also received honoraria from Danone and Astra Zeneca and is on the
   Scientific Board of Kibow, Inc. Dr Borghi received honoraria from
   Menarini Int, Takeda, Teejin, and Astrellas Drug Company and is on the
   Scientific Board of Menarini Int and Grunenthal. Dr Bakris is the
   principal investigator of the FIDELIO trial (Bayer) and on the steering
   committee of 2 other renal outcome trials, SONAR (AbbVie) and CREDENCE
   (Janssen), and 1 resistant hypertension trial, CALM-2 (Vascular
   Dynamics) and is a consultant for Merck and Relypsa. Dr Chertow has
   consulted for Astra Zeneca (formerly Ardea Biosciences). Dr Sanchez
   Lozada receives research support from Danone Research and Kibow Biotech,
   Inc and is a member of Colorado Research Partners, LLC. Dr Mount has
   involvement with UpToDate (hypouricemia card), Horizon Pharma
   (consultant), Kowa Pharmaceuticals (consultant), and Astra Zeneca (grant
   support). Dr Moe did consultations for AbbVie, Allena, Ardelyx,
   Genzyme-Sanofi, Relypsa, and Tricida. Dr Merriman has received research
   funding and has consulted with Ardea Biosciences and Ironwood
   Pharmaceuticals. The other authors declare that they have no relevant
   financial interests.
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NR 182
TC 456
Z9 491
U1 15
U2 267
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0272-6386
EI 1523-6838
J9 AM J KIDNEY DIS
JI Am. J. Kidney Dis.
PD JUN
PY 2018
VL 71
IS 6
BP 851
EP 865
DI 10.1053/j.ajkd.2017.12.009
PG 15
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA GG9NP
UT WOS:000433028100013
PM 29496260
OA Green Accepted
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Jafari, M
   Farhadi, F
   Rahimi, VB
   Rahmanian-Devin, P
   Askari, N
   Askari, VR
AF Jafari, Mandana
   Farhadi, Faeghe
   Rahimi, Vafa Baradaran
   Rahmanian-Devin, Pouria
   Askari, Nafiseh
   Askari, Vahid Reza
TI Mechanistic insights on lycopene usage against diabetes and associated
   complications
SO JOURNAL OF DIABETES AND METABOLIC DISORDERS
LA English
DT Review
DE Lycopene; Type 2 diabetes; Streptozotocin; Insulin; Inflammation;
   Oxidative stress; Neuropathy
ID OXIDATIVE STRESS; PROTECTIVE ROLE; METABOLIC SYNDROME; RATS; MELLITUS;
   NEUROINFLAMMATION; INFLAMMATION; AMELIORATION; NEPHROPATHY; DYSFUNCTION
AB Lycopene is a tetraterpene compound belonging to carotenoids that are widely present in tomatoes and similar products. It is known as a powerful anti-oxidant and a non-provitamin A carotenoid. Lycopene has been found to effectively improve diabetes mellitus and its complications, such as cardiac complications, disorders caused by oxidative stress, and liver and neurological disorders. Furthermore, free radicals have been shown to disrupt the action of insulin by changing the physical state of the target cell membrane, while carotenoids improve insulin secretion and function in blood sugar regulation by neutralizing free radicals. It, therefore, seems that targeted clinical studies are needed to investigate the therapeutic effect of lycopene against metabolic disorders induced by diabetes. This review aims to summarize information on the sources and potential uses of lycopene and the possible mechanisms involved in the reduction of the above diseases. Its protective effects, in terms of toxicity and safety, are also discussed. The literature sources used in this review were PubMed, Google Scholar, Scopus, and Web of Science databases.
C1 [Jafari, Mandana; Farhadi, Faeghe] Kerman Univ Med Sci, Herbal & Tradit Med Res Ctr, Kerman, Iran.
   [Rahimi, Vafa Baradaran] Mashhad Univ Med Sci, Fac Med, Dept Cardiovasc Dis, Mashhad, Iran.
   [Rahmanian-Devin, Pouria] North Khorasan Univ Med Sci, Sch Med, Dept Physiol & Pharmacol, Bojnurd, Iran.
   [Rahmanian-Devin, Pouria; Askari, Vahid Reza] Mashhad Univ Med Sci, Pharmacol Res Ctr Med Plants, Mashhad, Iran.
   [Askari, Nafiseh] Sabzevar Univ Med Sci, Student Res Comm, Sabzevar, Iran.
C3 Kerman University of Medical Sciences; Mashhad University of Medical
   Sciences; North Khorasan University of Medical Sciences; Mashhad
   University of Medical Sciences
RP Askari, VR (corresponding author), Mashhad Univ Med Sci, Pharmacol Res Ctr Med Plants, Mashhad, Iran.
EM mandana.jafary@gmail.com; faeghefarhadi@yahoo.com; vafa_br@yahoo.com;
   Pouryar2@gmail.com; naskari98@gmail.com; askariv@mums.ac.ir
RI Baradaran Rahimi, Vafa/AAR-4523-2021; jafari, mandana/R-3372-2017;
   rahmanian-devin, pouria/AAR-9668-2021; Askari, Vahid Reza/ABB-8991-2020
OI Baradaran Rahimi, Vafa/0000-0003-2320-5095; Askari, Vahid
   Reza/0000-0001-9268-6270
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NR 94
TC 0
Z9 0
U1 5
U2 5
PU SPRINGER INT PUBL AG
PI CHAM
PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND
EI 2251-6581
J9 J DIABETES METAB DIS
JI J. Diabetes Metab. Disord.
PD JAN 25
PY 2025
VL 24
IS 1
AR 57
DI 10.1007/s40200-025-01561-4
PG 14
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA T4T4R
UT WOS:001404947800001
PM 39868352
DA 2025-06-11
ER

PT J
AU Hamazaki, K
   Nishi, D
   Yonemoto, N
   Noguchi, H
   Kim, Y
   Matsuoka, Y
AF Hamazaki, K.
   Nishi, D.
   Yonemoto, N.
   Noguchi, H.
   Kim, Y.
   Matsuoka, Y.
TI The role of high-density lipoprotein cholesterol in risk for
   posttraumatic stress disorder: Taking a nutritional approach toward
   universal prevention
SO EUROPEAN PSYCHIATRY
LA English
DT Article
DE Posttraumatic stress disorder; Epidemiology; Lipid profile
ID METABOLIC SYNDROME; VETERANS; CHOLINESTERASE; ASSOCIATION; MORTALITY;
   PTSD
AB Several cross-sectional studies, but no prospective studies, have reported an association between an abnormal lipid profile and posttraumatic stress disorder (PTSD). We hypothesized that an abnormal lipid profile might predict risk for developing PTSD. In this prospective study, we analyzed data from 237 antidepressant-naive severely injured patients who participated in the Tachikawa Cohort of Motor Vehicle Accident Study. High-density lipoprotein cholesterol (HDL-C) levels at baseline were significantly lower in patients with PTSD than those without PTSD at 6 months after motor vehicle accident (MVA) and were inversely associated with risk for PTSD. In contrast, triglycerides (TG) at baseline were significantly higher in patients with PTSD than in those without PTSD at 6 months post-MVA and were positively associated with risk for PTSD. There was no clear association between lowdensity lipoprotein cholesterol or total cholesterol and risk for PTSD. In conclusion, low HDL-C and high TG may be risk factors for PTSD. Determining lipid profiles might help identify those at risk for PTSD after experiencing trauma. (C) 2014 Elsevier Masson SAS. All rights reserved.
C1 [Hamazaki, K.; Yonemoto, N.; Noguchi, H.; Matsuoka, Y.] Natl Ctr Neurol & Psychiat, Translat Med Ctr, Dept Clin Epidemiol, Kodaira, Tokyo 1878551, Japan.
   [Nishi, D.; Yonemoto, N.; Kim, Y.; Matsuoka, Y.] Natl Ctr Neurol & Psychiat, Natl Inst Mental Hlth, Kodaira, Tokyo 1878551, Japan.
   [Nishi, D.; Matsuoka, Y.] Natl Disaster Med Ctr, Dept Psychiat, Tokyo, Japan.
   [Hamazaki, K.] Toyama Univ, Fac Med, Dept Publ Hlth, Toyama 930, Japan.
   [Hamazaki, K.; Nishi, D.; Yonemoto, N.; Noguchi, H.; Matsuoka, Y.] Japan Sci & Technol Agcy, CREST, Tokyo, Japan.
C3 National Center for Neurology & Psychiatry - Japan; National Center for
   Neurology & Psychiatry - Japan; University of Toyama; Japan Science &
   Technology Agency (JST)
RP Matsuoka, Y (corresponding author), Natl Ctr Neurol & Psychiat, Translat Med Ctr, Dept Clin Epidemiol, 4-1-1 Ogawahigashi Cho, Kodaira, Tokyo 1878551, Japan.
EM yutaka@ncnp.go.jp
RI Matsuoka, Yutaka/N-1588-2019; Nishi, Daisuke/AAH-7211-2019; Naohiro,
   Yonemoto/Y-3761-2019
OI Nishi, Daisuke/0000-0001-9349-3294
FU Japanese Ministry of Health, Labor, and Welfare [16190501, 19230701,
   2030701]; National Center of Neurology and Psychiatry, CREST Japan
   Science and Technology Agency [24-4]
FX We thank Mrs. Kyoko Akutsu and Mrs. Yumiko Kamoshida for clinical data
   management. This work was supported by grants from the Japanese Ministry
   of Health, Labor, and Welfare (Research on Psychiatric and Neurological
   Disease and Mental Health: 16190501, 19230701, and 2030701), an
   Intramural Research Grant (24-4) for Neurological and Psychiatric
   Disorders from the National Center of Neurology and Psychiatry, CREST
   Japan Science and Technology Agency. None of these funding sources had
   any role in the design and conduct of the study; collection, management,
   analysis, and interpretation of results; or preparation of the
   manuscript.
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NR 35
TC 7
Z9 7
U1 0
U2 12
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI PARIS
PA 23 RUE LINOIS, 75724 PARIS, FRANCE
SN 0924-9338
EI 1778-3585
J9 EUR PSYCHIAT
JI Eur. Psychiat.
PD SEP
PY 2014
VL 29
IS 7
BP 408
EP 413
DI 10.1016/j.eurpsy.2014.05.002
PG 6
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA AO5OR
UT WOS:000341395000003
PM 24969103
OA Bronze
DA 2025-06-11
ER

PT J
AU Xie, ZX
   Xia, SF
   Le, GW
AF Xie, Zhenxing
   Xia, Shufang
   Le, Guo-Wei
TI Gamma-aminobutyric acid improves oxidative stress and function of the
   thyroid in high-fat diet fed mice
SO JOURNAL OF FUNCTIONAL FOODS
LA English
DT Article
DE Obesity; Oxidative stress; Hypothyroidism; Thyroid stimulating hormone;
   Thyroid hormone
ID METABOLIC SYNDROME; IODOTHYRONINE DEIODINASES; MESSENGER-RNA;
   EXPRESSION; HORMONE; OBESITY; CELLS; NRF2; ACTIVATION; GENES
AB Redox status and thyroid functions of diet-induced obesity (DIO) and DIO-resistant (DIO-R) mice from 20-week high-fat diet-fed (HFD) mice were studied (study I). Whether anti-obesity action of gamma-aminobutyric acid (GABA) in HFD mice was related to its antioxidative action or improvement in thyroid function was also examined (study II) by GABA in drinking water (0.2, 0.12 and 0.06%). In DIO mice, thyroid stimulating hormone (TSH) remarkably increased, free thyroid hormones (THs) decreased, thyroid structures deformed and expressions of THs synthesis-specific and thyroid antioxidalive markers, THs receptors beta and deiodinases in hypothalamus and liver decreased. DIO-R mice showed normalized TSH, increased THs and its functions. Three GABA treatments normalized TSH, while 0.2% and 0.12% GABA treatments restored redox status, raised THs excretions and functions. Consequently, Down-regulated thyroid and THs functions in DIO mice accounted for obesity. GABA could prevent obesity by ameliorating oxidative stress and HFD-disrupted functions of thyroid and THs. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Xie, Zhenxing; Xia, Shufang; Le, Guo-Wei] Jiangnan Univ, Sch Food Sci & Technol, State Key Lab Food Sci & Technol, Wuxi 214122, Jiangsu, Peoples R China.
C3 Jiangnan University
RP Le, GW (corresponding author), Jiangnan Univ, Sch Food Sci & Technol, State Key Lab Food Sci & Technol, Wuxi 214122, Jiangsu, Peoples R China.
EM lgw@jiangnan.edu.cn
FU 12th Five-Year Plan for Science and Technology Development
   [2012BAD33B05]
FX This work was supported by 12th Five-Year Plan for Science and
   Technology Development (No. 2012BAD33B05).
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NR 52
TC 41
Z9 46
U1 2
U2 39
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1756-4646
J9 J FUNCT FOODS
JI J. Funct. Food.
PD MAY
PY 2014
VL 8
BP 76
EP 86
DI 10.1016/j.jff.2014.03.003
PG 11
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA AI5DH
UT WOS:000336885100010
DA 2025-06-11
ER

PT J
AU Panis, C
   Herrera, ACSA
   Aranome, AMF
   Victorino, VJ
   Michelleti, PL
   Morimoto, HK
   Cecchini, AL
   Simao, ANC
   Cecchini, R
AF Panis, C.
   Herrera, A. C. S. A.
   Aranome, A. M. F.
   Victorino, V. J.
   Michelleti, P. L.
   Morimoto, H. K.
   Cecchini, A. L.
   Simao, A. N. C.
   Cecchini, R.
TI Clinical insights from adiponectin analysis in breast cancer patients
   reveal its anti-inflammatory properties in non-obese women
SO MOLECULAR AND CELLULAR ENDOCRINOLOGY
LA English
DT Article
DE Adiponectin; Breast cancer; Inflammation; Oxidative stress
ID OXIDATIVE STRESS; METABOLIC SYNDROME; INFLAMMATION; PHOSPHOLIPIDS;
   ACTIVATION; MECHANISMS; ADIPOKINES; MARKERS; LEPTIN; RISK
AB Adiponectin is a cytokine reported as a determinant of poor prognosis in women with breast cancer. However, because data regarding its role in breast cancer have been obtained primarily from studies employing overweight or obese women, the adiponectin profile in non-obese women is poorly understood. In this study, we determined adiponectin levels in plasma from non-obese women with breast cancer and investigated a possible correlation with systemic inflammatory status. We determined the plasma adiponectin levels as well as biochemical and oxidative stress parameters in 80 women. Our results revealed that plasma adiponectin levels were affected by chemotherapy, estrogen receptor status, and disease progression. Adiponectin was positively correlated with antioxidant levels, without affecting either the metastatic behavior of disease or patient outcome. These findings highlight adiponectin as a novel player in the endocrine signaling that modulates the oxidative inflammatory response in human breast cancer, and contribute to the understanding of the role of adiponectin in pathological conditions in non-obese women. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
C1 [Panis, C.; Herrera, A. C. S. A.; Aranome, A. M. F.; Michelleti, P. L.; Cecchini, A. L.; Cecchini, R.] Univ Estadual Londrina, Dept Gen Pathol, Lab Physiopathol & Free Rad, BR-86051990 Londrina, Parana, Brazil.
   [Morimoto, H. K.; Simao, A. N. C.] Univ Estadual Londrina, Dept Pharm, Univ Hosp, BR-86051990 Londrina, Parana, Brazil.
   [Victorino, V. J.] Univ Sao Paulo, Sao Paulo, Brazil.
C3 Universidade Estadual de Londrina; Universidade Estadual de Londrina;
   Universidade de Sao Paulo
RP Panis, C (corresponding author), Univ Estadual Londrina, Ctr Biol Sci, Dept Gen Pathol, Lab Pathophysiol & Free Rad, BR-86051990 Londrina, Brazil.
EM carolpanis@sercomtel.com.br
RI Simão, Andrea/AAM-4892-2021; Victorino, Vanessa/A-5039-2014; Cecchini,
   Alessandra/F-9338-2013; PANIS, CAROLINA/O-1490-2015; Cecchini,
   Rubens/D-9811-2013
OI Jacob Victorino, Vanessa/0000-0001-9339-2653; PANIS,
   CAROLINA/0000-0002-0104-4369; Cecchini, Rubens/0000-0001-9941-2344;
   Cecchini, Alessandra/0000-0003-0575-9879
FU Fundacao Araucaria; CAPES
FX This work was supported by the Fundacao Araucaria and CAPES.
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NR 36
TC 9
Z9 9
U1 0
U2 10
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0303-7207
J9 MOL CELL ENDOCRINOL
JI Mol. Cell. Endocrinol.
PD JAN 25
PY 2014
VL 382
IS 1
BP 190
EP 196
DI 10.1016/j.mce.2013.09.030
PG 7
WC Cell Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Endocrinology & Metabolism
GA 299UQ
UT WOS:000330421600020
PM 24095646
DA 2025-06-11
ER

PT J
AU Mahboob, A
   Samuel, SM
   Mohamed, A
   Wani, MY
   Ghorbel, S
   Miled, N
   Buesselberg, D
   Chaari, A
AF Mahboob, Anns
   Samuel, Samson Mathews
   Mohamed, Arif
   Wani, Mohmmad Younus
   Ghorbel, Sofiane
   Miled, Nabil
   Buesselberg, Dietrich
   Chaari, Ali
TI Role of flavonoids in controlling obesity: molecular targets and
   mechanisms
SO FRONTIERS IN NUTRITION
LA English
DT Review
DE anti-obesity therapy; flavonoids; metabolic syndrome; natural compounds;
   obesity
ID FATTY LIVER-DISEASE; ACTIVATED PROTEIN-KINASE; PLACEBO-CONTROLLED TRIAL;
   DIET-INDUCED OBESITY; OXIDATIVE STRESS; GUT MICROBIOTA;
   INSULIN-RESISTANCE; ALPHA-GLUCOSIDASE; IN-VITRO; ANTIOXIDANT ACTIVITIES
AB Obesity presents a major health challenge that increases the risk of several non-communicable illnesses, such as but not limited to diabetes, hypertension, cardiovascular diseases, musculoskeletal and neurological disorders, sleep disorders, and cancers. Accounting for nearly 8% of global deaths (4.7 million) in 2017, obesity leads to diminishing quality of life and a higher premature mortality rate among affected individuals. Although essentially dubbed as a modifiable and preventable health concern, prevention, and treatment strategies against obesity, such as calorie intake restriction and increasing calorie burning, have gained little long-term success. In this manuscript, we detail the pathophysiology of obesity as a multifactorial, oxidative stress-dependent inflammatory disease. Current anti-obesity treatment strategies, and the effect of flavonoid-based therapeutic interventions on digestion and absorption, macronutrient metabolism, inflammation and oxidative stress and gut microbiota has been evaluated. The use of several naturally occurring flavonoids to prevent and treat obesity with a long-term efficacy, is also described.
C1 [Mahboob, Anns; Chaari, Ali] Qatar Fdn, Dept Premed Educ, Weill Cornell Med Qatar, Educ City, Doha, Qatar.
   [Samuel, Samson Mathews; Buesselberg, Dietrich] Qatar Fdn, Dept Physiol & Biophys, Weill Cornell Med Qatar, Educ City, Doha, Qatar.
   [Mohamed, Arif; Wani, Mohmmad Younus; Miled, Nabil] Univ Jeddah, Coll Sci, Jeddah, Saudi Arabia.
   [Ghorbel, Sofiane] Univ Jeddah, Sci & Arts Khulis, Jeddah, Saudi Arabia.
C3 Qatar Foundation (QF); Weill Cornell Medical College Qatar; Qatar
   Foundation (QF); Weill Cornell Medical College Qatar; University of
   Jeddah; University of Jeddah
RP Chaari, A (corresponding author), Qatar Fdn, Dept Premed Educ, Weill Cornell Med Qatar, Educ City, Doha, Qatar.; Buesselberg, D (corresponding author), Qatar Fdn, Dept Physiol & Biophys, Weill Cornell Med Qatar, Educ City, Doha, Qatar.; Miled, N (corresponding author), Univ Jeddah, Coll Sci, Jeddah, Saudi Arabia.
EM nemiled@uj.edu.sa; dib2015@qatar-med.cornell.edu;
   alc2033@qatar-med.cornell.edu
RI Samuel, Samson/AAV-6263-2020; Miled, Nabil/ABC-6773-2020; Chaari,
   Ali/AEQ-0174-2022; Wani, Mohmmad/AAJ-5016-2020
OI Miled, Nabil/0000-0001-7445-6324; Ghorbel, Sofiane/0000-0001-8793-4882
FU National Priorities Research Program [NPRP11S-1214-170101]; Qatar
   National Research Fund (QNRF)
FX SMS was supported by a National Priorities Research Program grant
   (NPRP11S-1214-170101; June 2019-current) awarded to DB, from the Qatar
   National Research Fund (QNRF;
   https://mis.qgrants.org/Public/AwardDetails.aspx?ParamPid=fghmdaekde).
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NR 210
TC 17
Z9 18
U1 4
U2 22
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD MAY 12
PY 2023
VL 10
AR 1177897
DI 10.3389/fnut.2023.1177897
PG 19
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA H2VY0
UT WOS:000994607300001
PM 37252233
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Nicoll, R
   Henein, MY
AF Nicoll, Rachel
   Henein, Michael Y.
TI Caloric Restriction and Its Effect on Blood Pressure, Heart Rate
   Variability and Arterial Stiffness and Dilatation: A Review of the
   Evidence
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE blood pressure; heart rate variability; arterial stiffness;
   flow-mediated dilatation; caloric restriction fasting
ID CARDIOVASCULAR-DISEASE RISK; NITRIC-OXIDE SYNTHASE; VASCULAR ENDOTHELIAL
   DYSFUNCTION; WEIGHT-LOSS; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   BODY-WEIGHT; ESSENTIAL-HYPERTENSION; OXIDATIVE STRESS; RANDOMIZED-TRIAL
AB Essential hypertension, fast heart rate, low heart rate variability, sympathetic nervous system dominance over parasympathetic, arterial stiffness, endothelial dysfunction and poor flow-mediated arterial dilatation are all associated with cardiovascular mortality and morbidity. This review of randomised controlled trials and other studies demonstrates that caloric restriction (CR) is capable of significantly improving all these parameters, normalising blood pressure (BP) and allowing patients to discontinue antihypertensive medication, while never becoming hypotensive. CR appears to be effective regardless of age, gender, ethnicity, weight, body mass index (BMI) or a diagnosis of metabolic syndrome or type 2 diabetes, but the greatest benefit is usually observed in the sickest subjects and BP may continue to improve during the refeeding period. Exercise enhances the effects of CR only in hypertensive subjects. There is as yet no consensus on the mechanism of effect of CR and it may be multifactorial. Several studies have suggested that improvement in BP is related to improvement in insulin sensitivity, as well as increased nitric oxide production through improved endothelial function. In addition, CR is known to induce SIRT1, a nutrient sensor, which is linked to a number of beneficial effects in the body.
C1 [Nicoll, Rachel] Umea Univ, Dept Publ Hlth & Clin Med, S-90187 Umea, Sweden.
   Umea Univ, Heart Ctr, S-90187 Umea, Sweden.
C3 Umea University; Umea University
RP Nicoll, R (corresponding author), Umea Univ, Dept Publ Hlth & Clin Med, S-90187 Umea, Sweden.
EM rachel.nicoll@umu.se; michael.henein@medicin.umu.se
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NR 101
TC 59
Z9 68
U1 0
U2 9
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD MAR
PY 2018
VL 19
IS 3
AR 751
DI 10.3390/ijms19030751
PG 18
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA GA4OO
UT WOS:000428309800108
PM 29518898
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Strat, KM
   Rowley, TJ
   Smithson, AT
   Tessem, JS
   Hulver, MW
   Liu, D
   Davy, BM
   Davy, KP
   Neilson, AP
AF Strat, Karen M.
   Rowley, Thomas J.
   Smithson, Andrew T.
   Tessem, Jeffery S.
   Hulver, Matthew W.
   Liu, Dongmin
   Davy, Brenda M.
   Davy, Kevin P.
   Neilson, Andrew P.
TI Mechanisms by which cocoa flavanols improve metabolic syndrome and
   related disorders
SO JOURNAL OF NUTRITIONAL BIOCHEMISTRY
LA English
DT Review
DE Epicatechin; Procyanidins; Diabetes; beta-Cells; GLP-1; Endotoxin
ID GLUCAGON-LIKE PEPTIDE-1; GRAPE SEED EXTRACT; HIGH-FAT DIET; PANCREATIC
   BETA-CELLS; LDL OXIDATIVE SUSCEPTIBILITY; LIQUOR PROCYANIDIN EXTRACT;
   TYPE-2 DIABETIC SUBJECTS; BLOOD-GLUCOSE LEVELS; SKELETAL-MUSCLE; GUT
   MICROBIOTA
AB Dietary administration of cocoa flavanols may be an effective complementary strategy for alleviation or prevention of metabolic syndrome, particularly glucose intolerance. The complex flavanol composition of cocoa provides the ability to interact with a variety of molecules, thus allowing numerous opportunities to ameliorate metabolic diseases. These interactions likely occur primarily in the gastrointestinal tract, where native cocoa flavanol concentration is high. Flavanols may antagonize digestive enzymes and glucose transporters, causing a reduction in glucose excursion, which helps patients with metabolic disorders maintain glucose homeostasis. Unabsorbed flavanols, and ones that undergo enterohepatic recycling, will proceed to the colon where they can exert prebiotic effects on the gut microbiota. Interactions with the gut microbiota may improve gut barrier function, resulting in attenuated endotoxin absorption. Cocoa may also positively influence insulin signaling, possibly by relieving insulin-signaling pathways from oxidative stress and inflammation and/or via a heightened incretin response. The purpose of this review is to explore the mechanisms that underlie these outcomes, critically review the current body of literature related to those mechanisms, explore the implications of these mechanisms for therapeutic utility, and identify emerging or needed areas of research that could advance our understanding of the mechanisms of action and therapeutic potential of cocoa flavanols. (C) 2016 Elsevier Inc. All rights reserved.
C1 [Strat, Karen M.; Hulver, Matthew W.; Liu, Dongmin; Davy, Brenda M.; Davy, Kevin P.] Virginia Tech, Dept Human Nutr Foods & Exercise, Blacksburg, VA USA.
   [Rowley, Thomas J.; Tessem, Jeffery S.] Brigham Young Univ, Dept Nutr Dietet & Food Sci, Provo, UT 84602 USA.
   [Smithson, Andrew T.; Neilson, Andrew P.] Virginia Tech, Dept Food Sci & Technol, Blacksburg, VA USA.
   [Hulver, Matthew W.] Virginia Tech, Metab Phenotyping Core Facil, Blacksburg, VA USA.
C3 Virginia Polytechnic Institute & State University; Brigham Young
   University; Virginia Polytechnic Institute & State University; Virginia
   Polytechnic Institute & State University
RP Neilson, AP (corresponding author), 1981 Kraft Dr, Blacksburg, VA 24060 USA.
EM andrewn@vt.edu
RI Neilson, Andrew/T-4241-2019; Tessem, Jeffery/AAH-1052-2019
OI Tessem, Jeffery/0000-0003-3081-3187; Neilson, Andrew/0000-0001-5497-663X
FU Hershey Co., Hershey, PA
FX K.M. Strat, M.W. Hulver, B.M. Davy, K.P. Davy and A.P. Neilson currently
   have research support from The Hershey Co., Hershey, PA. No employee of
   The Hershey Co. assisted in the conceptualization, preparation or
   editing of this review.
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NR 240
TC 61
Z9 70
U1 2
U2 63
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0955-2863
EI 1873-4847
J9 J NUTR BIOCHEM
JI J. Nutr. Biochem.
PD SEP
PY 2016
VL 35
BP 1
EP 21
DI 10.1016/j.jnutbio.2015.12.008
PG 21
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA DU7TX
UT WOS:000382418600001
PM 27560446
DA 2025-06-11
ER

PT J
AU Panchal, SK
   Poudyal, H
   Ward, LC
   Waanders, J
   Brown, L
AF Panchal, Sunil K.
   Poudyal, Hemant
   Ward, Leigh C.
   Waanders, Jennifer
   Brown, Lindsay
TI Modulation of tissue fatty acids by L-carnitine attenuates metabolic
   syndrome in diet-induced obese rats
SO FOOD & FUNCTION
LA English
DT Article
ID INSULIN-RESISTANCE; ENERGY-EXPENDITURE; HIGH-CARBOHYDRATE;
   LIVER-DISEASE; CARDIOVASCULAR-DISEASE; DIABETIC-PATIENTS; OXIDATIVE
   STRESS; LIPID-METABOLISM; SUPPLEMENTATION; FRUCTOSE
AB Obesity and dyslipidaemia are metabolic defects resulting from impaired lipid metabolism. These impairments are associated with the development of cardiovascular disease and non-alcoholic fatty liver disease. Correcting the defects in lipid metabolism may attenuate obesity and dyslipidaemia, and reduce cardiovascular risk and liver damage. L-Carnitine supplementation was used in this study to enhance fatty acid oxidation so as to ameliorate diet-induced disturbances in lipid metabolism. Male Wistar rats (8-9 weeks old) were fed with either corn starch or high-carbohydrate, high-fat diets for 16 weeks. Separate groups were supplemented with L-carnitine (1.2% in food) on either diet for the last 8 weeks of the protocol. High-carbohydrate, high-fat diet-fed rats showed central obesity, dyslipidaemia, hypertension, impaired glucose tolerance, hyperinsulinaemia, cardiovascular remodelling and non-alcoholic fatty liver disease. L-Carnitine supplementation attenuated these high-carbohydrate, high-fat diet-induced changes, together with modifications in lipid metabolism including the inhibition of stearoyl-CoA desaturase-1 activity, reduced storage of short-chain monounsaturated fatty acids in the tissues with decreased linoleic acid content and trans fatty acids stored in retroperitoneal fat. Thus, L-carnitine supplementation attenuated the signs of metabolic syndrome through inhibition of stearoyl-CoA desaturase-1 activity, preferential beta-oxidation of some fatty acids and increased storage of saturated fatty acids and relatively inert oleic acid in the tissues.
C1 [Panchal, Sunil K.; Brown, Lindsay] Univ So Queensland, Inst Agr & Environm, Toowoomba, Qld 4350, Australia.
   [Poudyal, Hemant] Kyoto Univ, Dept Diabet Endocrinol & Nutr, Hakubi Ctr Adv Res, Kyoto, Japan.
   [Ward, Leigh C.] Univ Queensland, Sch Chem & Mol Biosci, Brisbane, Qld 4072, Australia.
   [Waanders, Jennifer] Univ Queensland, Sch Agr & Food Sci, Brisbane, Qld 4072, Australia.
   [Brown, Lindsay] Univ So Queensland, Sch Hlth & Wellbeing, Toowoomba, Qld 4350, Australia.
C3 University of Southern Queensland; Kyoto University; University of
   Queensland; University of Queensland; University of Southern Queensland
RP Panchal, SK (corresponding author), Univ So Queensland, Inst Agr & Environm, Toowoomba, Qld 4350, Australia.
EM Lindsay.Brown@usq.edu.au
RI Poudyal, Hemant/HOH-9324-2023; Ward, Leigh/L-4461-2019
OI Panchal, Sunil K/0000-0001-5464-3376
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NR 49
TC 19
Z9 22
U1 0
U2 10
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PY 2015
VL 6
IS 8
BP 2496
EP 2506
DI 10.1039/c5fo00480b
PG 11
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA CO4KD
UT WOS:000359128700007
PM 26190559
DA 2025-06-11
ER

PT J
AU Puchau, B
   Zulet, MA
   Hermsdorff, HHM
   Navarro-Blasco, I
   Martínez, JA
AF Puchau, Blanca
   Angeles Zulet, Maria
   Miranda Hermsdorff, Helen Hermana
   Navarro-Blasco, Inigo
   Alfredo Martinez, J.
TI Nail Antioxidant Trace Elements Are Inversely Associated with
   Inflammatory Markers in Healthy Young Adults
SO BIOLOGICAL TRACE ELEMENT RESEARCH
LA English
DT Article
DE Inflammation; Oxidative stress; Antioxidant; Trace element; Nail;
   Selenium; Zinc; Copper
ID ACUTE MYOCARDIAL-INFARCTION; METABOLIC SYNDROME; HOMOCYSTEINE LEVELS;
   SELENIUM EXPOSURE; HEAVY-METALS; SERUM COPPER; WHOLE-BLOOD; PLASMA;
   ZINC; OBESITY
AB Antioxidant intake may be linked to a reduction of the chronic low-grade inflammatory state related to obesity and several accompanying disorders such as insulin resistance, cardiovascular diseases, and metabolic syndrome. So, the aim of this study was to evaluate the potential associations between nail trace elements and several indicators in healthy young adults, emphasizing on the putative effect of antioxidant trace element intake on inflammation-related marker concentrations. This study enrolled 149 healthy young adults, whose anthropometrical and blood pressure values as well as lifestyle features were analyzed. Fasting blood samples were collected for the biochemical and inflammation-related measurements (C-reactive protein, tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-6, IL-18, and homocysteine). Nail samples were collected for the analysis of selenium, zinc, and copper concentrations. Our results showed that nail selenium was negatively associated with IL-18; nail zinc concentrations were inversely related to circulating IL-6, IL-18, and TNF-alpha, whereas nail copper (Cu) and Cu/selenium values were negatively correlated with homocysteine levels and the Cu/zinc ratio was unaffected. In conclusion, nail content on some trace elements related to antioxidant defense mechanisms seems to be associated with several inflammation-related markers linked to chronic diseases in apparently healthy young adults, which is of interest to understand the role of antioxidant intake.
C1 [Puchau, Blanca; Angeles Zulet, Maria; Miranda Hermsdorff, Helen Hermana; Alfredo Martinez, J.] Univ Navarra, Dept Nutr & Food Sci, Pamplona 31008, Spain.
   [Navarro-Blasco, Inigo] Univ Navarra, Dept Chem & Soil Sci, Pamplona 31008, Spain.
C3 University of Navarra; University of Navarra
RP Martínez, JA (corresponding author), Univ Navarra, Dept Nutr & Food Sci, Calle Irunlarrea 1, Pamplona 31008, Spain.
EM jalfmtz@unav.es
RI Martinez Hernandez, J Alfredo/K-8709-2014; Zulet, M.
   Angeles/H-1317-2017; Hermsdorff, Helen Hermana Miranda/H-4525-2015;
   Navarro-Blasco, Inigo/D-8148-2012
OI Martinez Hernandez, J Alfredo/0000-0001-5218-6941; Zulet, M.
   Angeles/0000-0002-3926-0892; Hermsdorff, Helen Hermana
   Miranda/0000-0002-4441-6572; Navarro-Blasco, Inigo/0000-0003-1863-0580
FU Linea Especial about Nutrition, Obesity and Health [LE/97]; Health
   Department of the Government of Navarra, Ibercaja [22/2007]; University
   of Navarra; Ministry of Education of Brazil [375605-0]
FX This study is supported by the Linea Especial about Nutrition, Obesity
   and Health (LE/97), the Health Department of the Government of Navarra
   (22/2007), Ibercaja, the ADA fellowships scheme of the University of
   Navarra and the Capes Foundation of the Ministry of Education of Brazil
   (375605-0). We thank Amaia Gonzalez de Echavarri for her help with the
   recruitment and the data collection, Veronica Ciaurriz and Ana Lorente
   for technical assistance, Blanca Martinez de Morentin and Salome Perez
   for assistance with the data collection, and all those who volunteered
   to participate in the study.
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NR 44
TC 10
Z9 10
U1 0
U2 7
PU HUMANA PRESS INC
PI TOTOWA
PA 999 RIVERVIEW DRIVE SUITE 208, TOTOWA, NJ 07512 USA
SN 0163-4984
EI 1559-0720
J9 BIOL TRACE ELEM RES
JI Biol. Trace Elem. Res.
PD MAR
PY 2010
VL 133
IS 3
BP 304
EP 312
DI 10.1007/s12011-009-8443-5
PG 9
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 562QQ
UT WOS:000275068600008
PM 19582378
DA 2025-06-11
ER

PT J
AU Martín-Peláez, S
   Serra-Majem, L
   Cano-Ibáñez, N
   Martínez-González, MA
   Salas-Salvadó, J
   Corella, D
   Lassale, C
   Martínez, JA
   Alonso-Gómez, AM
   Wärnberg, J
   Vioque, J
   Romaguera, D
   López-Miranda, J
   Estruch, R
   Tinahones, FJ
   Lapetra, J
   Fernández-Aranda, F
   Bueno-Cavanillas, A
   Tur, JA
   Martín, V
   Pintó, X
   Delgado-Rodríguez, M
   Matía, P
   Vidal, J
   Vázquez, C
   Daimiel, L
   Ros, E
   Toledo, E
   Nishi, SK
   Sorli, JV
   Malcampo, M
   Zulet, MA
   Moreno-Rodríguez, A
   Cueto-Galán, R
   Vivancos-Aparicio, D
   Colom, A
   García-Ríos, A
   Casas, R
   Bernal-López, MR
   Santos-Lozano, JM
   Vázquez, Z
   Gómez-Martínez, C
   Ortega-Azorín, C
   del Val, JL
   Abete, I
   Goikoetxea-Bahon, A
   Pascual, E
   Becerra-Tomás, N
   Chillarón, JJ
   Sánchez-Villegas, A
AF Martin-Pelaez, Sandra
   Serra-Majem, Lluis
   Cano-Ibanez, Naomi
   Angel Martinez-Gonzalez, Miguel
   Salas-Salvado, Jordi
   Corella, Dolores
   Lassale, Camille
   Alfredo Martinez, Jose
   Alonso-Gomez, Angel M.
   Warnberg, Julia
   Vioque, Jesus
   Romaguera, Dora
   Lopez-Miranda, Jose
   Estruch, Ramon
   Tinahones, Francisco J.
   Lapetra, Jose
   Fernandez-Aranda, Fernando
   Bueno-Cavanillas, Aurora
   Tur, Josep A.
   Martin, Vicente
   Pinto, Xavier
   Delgado-Rodriguez, Miguel
   Matia, Pilar
   Vidal, Josep
   Vazquez, Clotilde
   Daimiel, Lidia
   Ros, Emili
   Toledo, Estefania
   Nishi, Stephanie K.
   Sorli, Jose V.
   Malcampo, Mireia
   Angeles Zulet, M.
   Moreno-Rodriguez, Anai
   Cueto-Galan, Raquel
   Vivancos-Aparicio, Diego
   Colom, Antoni
   Garcia-Rios, Antonio
   Casas, Rosa
   Rosa Bernal-Lopez, M.
   Manuel Santos-Lozano, Jose
   Vazquez, Zenaida
   Gomez-Martinez, Carlos
   Ortega-Azorin, Carolina
   Luis del Val, Jose
   Abete, Itziar
   Goikoetxea-Bahon, Amaia
   Pascual, Elena
   Becerra-Tomas, Nerea
   Chillaron, Juan J.
   Sanchez-Villegas, Almudena
TI Contribution of cardio-vascular risk factors to depressive status in the
   PREDIMED-PLUS Trial. A cross-sectional and a 2-year longitudinal study
SO PLOS ONE
LA English
DT Article
ID PHYSICAL-ACTIVITY QUESTIONNAIRE; TYPE-2 DIABETES-MELLITUS; CHOLESTEROL
   LEVELS; INVENTORY-II; DISEASE; ASSOCIATION; POPULATION; VALIDATION;
   VALIDITY; ADULTS
AB Background
   Cardio-vascular disease and depression are thought to be closely related, due to shared risk factors. The aim of the study was to determine the association between cardio-vascular risk (CVR) factors and depressive status in a population (55-75 years) with metabolic syndrome (MetS) from the PREDIMED-Plus trial.
   Methods and findings
   Participants were classified into three groups of CVR according to the Framingham-based REGICOR function: (1) low (LR), (2) medium (MR) or (3) high/very high (HR). The Beck Depression Inventory-II (BDI-II) was used to assess depressive symptoms at baseline and after 2 years. The association between CVR and depressive status at baseline (n = 6545), and their changes after 2 years (n = 4566) were evaluated through multivariable regression models (logistic and linear models). HR women showed higher odds of depressive status than LR [OR (95% CI) = 1.78 (1.26, 2.50)]. MR and HR participants with total cholesterol < 160 mg/mL showed higher odds of depression than LR [OR (95% CI) = 1.77 (1.13, 2.77) and 2.83 (1.25, 6.42) respectively)] but those with total cholesterol >= 280 mg/mL showed lower odds of depression than LR [OR (95% CI) = 0.26 (0.07, 0.98) and 0.23 (0.05, 0.95), respectively]. All participants decreased their BDI-II score after 2 years, being the decrease smaller in MR and HR diabetic compared to LR [adjusted mean +/- SE = -0.52 +/- 0.20, -0.41 +/- 0.27 and -1.25 +/- 0.31 respectively). MR and HR participants with total cholesterol between 240-279 mg/mL showed greater decreases in the BDI-II score compared to LR (adjusted mean +/- SE = -0.83 +/- 0.37, -0.77 +/- 0.64 and 0.97 +/- 0.52 respectively).
   Conclusions
   Improving cardiovascular health could prevent the onset of depression in the elderly. Diabetes and total cholesterol in individuals at high CVR, may play a specific role in the precise response. International Standard Randomized Controlled Trial (ISRCTN89898870).
C1 [Martin-Pelaez, Sandra; Cano-Ibanez, Naomi; Bueno-Cavanillas, Aurora] Univ Granada, Dept Prevent Med & Publ Hlth, Granada, Spain.
   [Martin-Pelaez, Sandra; Cano-Ibanez, Naomi; Bueno-Cavanillas, Aurora; Delgado-Rodriguez, Miguel] Inst Invest Biosanitaria Granada ibs GRANADA, Granada, Spain.
   [Serra-Majem, Lluis; Angel Martinez-Gonzalez, Miguel; Salas-Salvado, Jordi; Corella, Dolores; Lassale, Camille; Alfredo Martinez, Jose; Alonso-Gomez, Angel M.; Warnberg, Julia; Romaguera, Dora; Lopez-Miranda, Jose; Estruch, Ramon; Tinahones, Francisco J.; Lapetra, Jose; Fernandez-Aranda, Fernando; Tur, Josep A.; Pinto, Xavier; Ros, Emili; Toledo, Estefania; Nishi, Stephanie K.; Moreno-Rodriguez, Anai; Colom, Antoni; Garcia-Rios, Antonio; Rosa Bernal-Lopez, M.; Manuel Santos-Lozano, Jose; Vazquez, Zenaida; Gomez-Martinez, Carlos; Luis del Val, Jose; Goikoetxea-Bahon, Amaia; Pascual, Elena; Becerra-Tomas, Nerea; Chillaron, Juan J.; Sanchez-Villegas, Almudena] Inst Hlth Carlos III, Ctr Invest Biomed Red Fisiopatol Obesidad & Nutr, Madrid, Spain.
   [Serra-Majem, Lluis; Fernandez-Aranda, Fernando; Sanchez-Villegas, Almudena] Univ Las Palmas Gran Canaria, Res Inst Biomed & Hlth Sci IUIBS, Las Palmas Gran Canaria, Spain.
   [Cano-Ibanez, Naomi; Vioque, Jesus; Bueno-Cavanillas, Aurora; Martin, Vicente] Inst Hlth Carlos III, Ctr Invest Biomed Red Epidemiol & Salud Publ CIBE, Madrid, Spain.
   [Angel Martinez-Gonzalez, Miguel; Vazquez, Zenaida; Pascual, Elena] Univ Navarra, IdiSNA, Dept Prevent Med & Publ Hlth, Pamplona, Spain.
   [Angel Martinez-Gonzalez, Miguel] Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA.
   [Salas-Salvado, Jordi; Nishi, Stephanie K.; Gomez-Martinez, Carlos; Becerra-Tomas, Nerea] Univ Rovira & Virgili, Dept Bioquim & Biotecnol, Unitat Nutr Humana, Reus, Spain.
   [Salas-Salvado, Jordi; Nishi, Stephanie K.; Gomez-Martinez, Carlos; Becerra-Tomas, Nerea] Univ Hosp St Joan de Reus, Nutr Unit, Reus, Spain.
   [Salas-Salvado, Jordi; Nishi, Stephanie K.; Gomez-Martinez, Carlos; Becerra-Tomas, Nerea] Inst Invest Sanit Pere Virgili IISPV, Reus, Spain.
   [Corella, Dolores; Sorli, Jose V.; Ortega-Azorin, Carolina] Univ Valencia, Dept Prevent Med, Valencia, Spain.
   [Lassale, Camille; Malcampo, Mireia; Luis del Val, Jose; Chillaron, Juan J.] Inst Hosp Invest Med Municipal Invest Med IMIM, Unit Cardiovasc Risk & Nutr, Barcelona, Spain.
   [Alfredo Martinez, Jose; Angeles Zulet, M.; Abete, Itziar] Univ Navarra, Dept Nutr Food Sci & Physiol, Pamplona, Spain.
   [Alfredo Martinez, Jose] CEI UAM CSIC, IMDEA Food, Precis Nutr Program, Madrid, Spain.
   [Alonso-Gomez, Angel M.; Moreno-Rodriguez, Anai; Goikoetxea-Bahon, Amaia] Univ Basque Country UPV EHU, Araba Univ Hosp, Osakidetza Basque Hlth Serv, Bioaraba Hlth Res Inst,Cardiovasc Resp & Metab Ar, Vitoria, Spain.
   [Warnberg, Julia; Cueto-Galan, Raquel] Univ Malaga, Inst Invest Biomed Malaga IBIMA, Sch Hlth Sci, Dept Nursing, Malaga, Spain.
   [Vioque, Jesus] ISABIAL UMH, Inst Invest Sanitaria & Biomed Alicante, Alicante, Spain.
   [Romaguera, Dora] Hlth Res Inst Balear Islands IdISBa, Palma De Mallorca, Spain.
   [Lopez-Miranda, Jose] Univ Cordoba, Reina Sofia Univ Hosp, Maimonides Biomed Res Inst Cordoba IMIBIC, Lipids & Atherosclerosis Unit,Dept Internal Med, Cordoba, Spain.
   [Estruch, Ramon; Casas, Rosa] Univ Barcelona, Hosp Clin, Inst Invest Biomed August Pi Sunyer IDIBAPS, Dept Internal Med, Barcelona, Spain.
   [Tinahones, Francisco J.; Rosa Bernal-Lopez, M.] Univ Malaga, Inst Invest Biomed Malaga IBIMA, Dept Endocrinol, Virgen Victoria Hosp, Malaga, Spain.
   [Lapetra, Jose; Manuel Santos-Lozano, Jose] Distrito Sanit Atenc Primaria Sevilla, Res Unit, Dept Family Med, Seville, Spain.
   [Tur, Josep A.] Univ Balear Isl, Res Grp Community Nutr & Oxidat Stress, Palma De Mallorca, Spain.
   [Martin, Vicente] Univ Leon, Inst Biomed IBIOMED, Leon, Spain.
   [Pinto, Xavier] Hosp Univ Bellvitge, Lipids & Vasc Risk Unit, Internal Med, Barcelona, Spain.
   [Delgado-Rodriguez, Miguel] Univ Jaen, Ctr Adv Studies Olive Grove & Olive Oils, Jaen, Spain.
   [Matia, Pilar] Inst Invest Sanit Hosp Clin San Carlos IdISSC, Dept Endocrinol & Nutr, Madrid, Spain.
   [Vidal, Josep] Inst Salud Carlos III ISCIII, CIBER Diabet & Enfermedades Metab CIBERDEM, Madrid, Spain.
   [Vidal, Josep] Univ Barcelona, Inst Invest Biomed August Pi Sunyer IDIBAPS, Hosp Clin, Dept Endocrinol, Barcelona, Spain.
   [Vazquez, Clotilde] Univ Autonoma Madrid, Hosp Fdn Jimenez Diaz, Dept Endocrinol & Nutr, Inst Invest Biomed IISFJD, Madrid, Spain.
   [Daimiel, Lidia] CEI UAM CSIC, IMDEA Food, Nutr Genom & Epigen Grp, Madrid, Spain.
   [Ros, Emili] Hosp Clin Barcelona, Inst Invest Biomed August Pi Sunyer IDIBAPS, Dept Endocrinol & Nutr, Lipid Clin, Barcelona, Spain.
   [Vivancos-Aparicio, Diego] Ctr Salud San Vicente 1, Alicante, Spain.
   [Sanchez-Villegas, Almudena] Univ Publ Navarra UPNA, IdisNA, Inst Innovat & Sustainable Dev Food Chain, Pamplona, Spain.
C3 University of Granada; Instituto de Investigacion Biosanitaria IBS
   Granada; CIBER - Centro de Investigacion Biomedica en Red; CIBEROBN;
   Universidad de Las Palmas de Gran Canaria; CIBER - Centro de
   Investigacion Biomedica en Red; CIBERESP; University of Navarra; Harvard
   University; Harvard T.H. Chan School of Public Health; Universitat
   Rovira i Virgili; University of Valencia; University of Navarra; Consejo
   Superior de Investigaciones Cientificas (CSIC); IMDEA Food Institute;
   University Hospital of Araba; University of Basque Country; Bioaraba
   Health Research Institute; Instituto de Investigacion Biomedica de
   Malaga y Plataforma en Nanomedicina (IBIMA); Universidad de Malaga;
   General University Hospital of Alicante; Universidad Miguel Hernandez de
   Elche; Universitat d'Alacant; Instituto de Investigacion Sanitaria y
   Biomedica de Alicante (ISABIAL); Universidad de Cordoba; University of
   Barcelona; Hospital Clinic de Barcelona; IDIBAPS; Universidad de Malaga;
   Instituto de Investigacion Biomedica de Malaga y Plataforma en
   Nanomedicina (IBIMA); Universitat de les Illes Balears; Universidad de
   Leon; University of Barcelona; Institut d'Investigacio Biomedica de
   Bellvitge (IDIBELL); Bellvitge University Hospital; Universidad de Jaen;
   CIBER - Centro de Investigacion Biomedica en Red; CIBERDEM; University
   of Barcelona; Hospital Clinic de Barcelona; IDIBAPS; Fundacion Jimenez
   Diaz; Autonomous University of Madrid; IMDEA Food Institute; Consejo
   Superior de Investigaciones Cientificas (CSIC); University of Barcelona;
   Hospital Clinic de Barcelona; IDIBAPS; Universidad Publica de Navarra
RP Martín-Peláez, S (corresponding author), Univ Granada, Dept Prevent Med & Publ Hlth, Granada, Spain.; Martín-Peláez, S (corresponding author), Inst Invest Biosanitaria Granada ibs GRANADA, Granada, Spain.
EM sandramartin@ugr.es
RI Corella, Dolores/L-9888-2014; Daimiel-Ruiz, Lidia/M-7779-2014; Malcampo,
   Mireia/HLH-0733-2023; González-Martel, Christian/M-8180-2013; Estruch,
   Ramon/AAZ-3723-2020; Pascual, Elena/L-8557-2014; Bueno-Cavanillas,
   Aurora/O-1513-2015; MARTIN-PELAEZ, SANDRA/G-4945-2015; Ortega-Azorín,
   Carolina/AAB-2355-2019; Nishi, Stephanie/GSN-1143-2022; Toledo,
   Estefania/H-6211-2014; Vioque, Jesus/A-1066-2008; Pintó,
   Xavier/AGI-4297-2022; Lopez-Miranda, Jose/Y-8306-2019; Lapetra,
   Jose/F-2552-2015; ALONSO GOMEZ, ANGEL/HLG-2476-2023; Zulet,
   M./H-1317-2017; Chillaron, Juan/MTF-9343-2025; Tur, Josep/AAE-5748-2020;
   Sorlí, José/L-8758-2014; Warnberg, Julia/G-1390-2011; Casas,
   Rosa/ABD-1915-2020; Sureda, Antoni/N-9588-2019; Tinahones,
   Francisco/AAB-2882-2020; Vidal, Josep/MIK-6936-2025; Sanchez-Villegas,
   Almudena/T-6733-2019; Lassale, Camille/ABE-7813-2020; Romaguera,
   Dora/ABE-7004-2020; Colom Fernandez, Antoni/JHU-4849-2023;
   Martinez-Gonzalez, Miguel/AAE-7669-2019; Rodríguez,
   Miguel/KCZ-1828-2024; del Val Garcia, Jose Luis/G-6195-2016;
   FERNANDEZ-ARANDA, FERNANDO/L-9762-2014; Becerra-Tomas,
   Nerea/H-3937-2018; Gomez Martinez, Carlos/AGJ-6387-2022; Martinez
   Hernandez, J Alfredo/K-8709-2014; Delgado Rodriguez, Miguel/H-4940-2017;
   Martin, Vicente/A-1597-2008; Salas-Salvado, Jordi/C-7229-2017;
   Vazquez-Ruiz, Zenaida/AAB-7202-2020
OI Sorli, Jose V/0000-0002-0130-2006; Lopez-Miranda,
   Jose/0000-0002-8844-0718; del Val Garcia, Jose Luis/0000-0002-0391-9368;
   FERNANDEZ-ARANDA, FERNANDO/0000-0002-2968-9898; Becerra-Tomas,
   Nerea/0000-0002-4429-6507; Nishi, Stephanie/0000-0002-7878-5368; Gomez
   Martinez, Carlos/0000-0002-3077-6702; Martinez Hernandez, J
   Alfredo/0000-0001-5218-6941; Casas, Rosa/0000-0002-0211-9166; Delgado
   Rodriguez, Miguel/0000-0002-3838-2548; MARTIN PELAEZ,
   SANDRA/0000-0002-2193-3913; Cueto Galan, Raquel/0000-0001-5846-5685;
   Tinahones, Francisco J/0000-0001-6871-4403; Sanchez Villegas,
   Almudena/0000-0001-7733-9238; Alonso Gomez, Angel
   Maria/0000-0003-2945-7509; Martin, Vicente/0000-0003-0552-2804;
   Cano-Ibanez, Naomi/0000-0002-3640-5486; Lassale,
   Camille/0000-0002-9340-2708; Salas-Salvado, Jordi/0000-0003-2700-7459;
   Martinez-Gonzalez, Miguel A./0000-0002-3917-9808; Vazquez-Ruiz,
   Zenaida/0000-0002-6828-9627
FU European Research Council [340918]; Spanish Government (ISCIII) through
   the Fondo de Investigacion para la Salud (FIS) - European Regional
   Development Fund [PI13/00673, PI13/00492, PI13/00272, PI13/01123,
   PI13/00462, PI13/00233, PI13/02184, PI13/00728, PI13/01090, PI13/01056,
   PI14/01722, PI14/00636, PI14/00618, PI14/00696, PI14/01206, PI14/01919,
   PI14/00853, PI14/01374, PI16/00473, PI16/00662, PI16/01873, PI16/01094,
   PI16/00501, PI16/00533, PI16/00381, PI16/00366, PI16/01522, PI16/01120,
   PI17/00764, PI17/01183, PI17/00855, PI17/01347, PI17/00525, PI17/01827,
   PI17/00532, PI17/00215, PI17/01441, PI17/00508, PI17/01732, PI17/00926];
   International Nut&Dried Fruit Council-FESNAD [201302]; Recercaixa
   [2013ACUP00194]; Department of Health, Generalitat de Cataluna
   [SLT006/17/00246]; Consejeria de Salud de la Junta de Andalucia
   [PI0458/2013, PS0358/2016, PI0137/2018]; Generalitat Valenciana
   [PROMETEO/2017/017]; SEMERGEN; CIBEROBN; FEDER; ISCIII [CB06/03]; EU
   [728018, 847879]
FX The PREDIMED-Plus trial was supported by the European Research Council
   through a grant to MAM (Advanced Research Grant 2013-2018; 340918). The
   project was also supported by the official funding agency for biomedical
   research of the Spanish Government (ISCIII) through the Fondo de
   Investigacion para la Salud (FIS), which is co-funded by the European
   Regional Development Fund (four coordinated FIS projects), who awarded
   grants to JS and JV (PI13/00673, PI13/00492, PI13/00272, PI13/01123,
   PI13/00462, PI13/00233, PI13/02184, PI13/00728, PI13/01090, PI13/01056,
   PI14/01722, PI14/00636, PI14/00618, PI14/00696, PI14/01206, PI14/01919,
   PI14/00853, PI14/01374, PI16/00473, PI16/00662, PI16/01873, PI16/01094,
   PI16/00501, PI16/00533, PI16/00381, PI16/00366, PI16/01522, PI16/01120,
   PI17/00764, PI17/01183, PI17/00855, PI17/01347, PI17/00525, PI17/01827,
   PI17/00532, PI17/00215, PI17/01441, PI17/00508, PI17/01732 and
   PI17/00926). The International Nut&Dried Fruit Council-FESNAD also
   provided funding through a grant to MAM (201302), and Recercaixa also
   awarded a grant to JS (2013ACUP00194). The Department of Health,
   Generalitat de Cataluna by the calls "Accio instrumental de programes de
   recerca orientats en lambit de la recercaila innovacioen salut" and "Pla
   estrategic de recerca i innovacioen salut (PERIS)," also awarded a grant
   to FF (SLT006/17/00246). This research was also partially funded by:
   Consejeria de Salud de la Junta de Andalucia (PI0458/2013, PS0358/2016,
   PI0137/2018); Generalitat Valenciana (PROMETEO/2017/017); SEMERGEN,
   CIBEROBN, FEDER and ISCIII (CB06/03); EU-H2020 Grants
   (Eat2beNICE/h2020-sfs2016-2, ref.728018; PRIME/h2020-SC1-BHC2018-2020,
   ref: 847879). The funders had no role in study design, data collection
   and analysis, decision to publish, or preparation of the manuscript.
   None of the funding sources took part in the design, collection,
   analysis or interpretation of the data or in the decision to submit the
   manuscript for publication.
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NR 43
TC 3
Z9 3
U1 0
U2 11
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PY 2022
VL 17
IS 4
AR e0265079
DI 10.1371/journal.pone.0265079
PG 18
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA VN3AR
UT WOS:001143683300001
PM 35417452
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Ghumman, NA
   Qamar, MA
   Khurrum, N
   Khan, ZA
   Ul Mustafa, Z
   Irshad, F
AF Ghumman, Nasim Aslam
   Qamar, Muhammad Adeel
   Khurrum, Nosheen
   Khan, Zahid Ahmad
   Ul Mustafa, Zia
   Irshad, Faiza
TI Clinical Symptomatology and Laboratory Diagnosis of Nonalcoholic Chronic
   Fatty Liver Disease
SO PAKISTAN JOURNAL OF MEDICAL & HEALTH SCIENCES
LA English
DT Article
DE NAFLD; hepatocellular carcinoma; cirrhosis
ID METABOLIC SYNDROME; PREVALENCE; STEATOHEPATITIS; EPIDEMIOLOGY;
   MANAGEMENT; FRUCTOSE; DIFFERS; INSULIN
AB Background: One of the leading causes for hepatocellular carcinoma is Nonalcoholic fatty liver diseases (NAFLD) that also increases incidence of mortality rates.
   Aim: To understand alterations biochemically and clinically in patients suffering from NAFLD since they are at stake of cirrhosis as well as nonalcoholic steatohepatitis (NASH) in case of Pakistani population.
   Methods: Patients suffering from NAFLD were selected for these case reaches that were all confirmed via ultrasonography. Candidates were tested negative for autoimmune or viral hepatitis serologic markers, no record was found with respect to liver disease related to metabolism, moreover candidates were also not administer any medication that has its impact on liver like Ursobil. Clinically and biochemically all the patients were tested for history, signs and symptoms and they depicted variables.
   Results: A enrollment of 80 candidates was carried out that included 38 female and 42 male, owing mean age of 40.4 years. The candidates with no diabetes and obesity were 26.4% and 18.3%, respectively. Late dinner sleep disorders and delayed sleep were the most detectable reasons in patients suffering from NAFLD. Moreover, thirst sensation, anxiety, bloating, and upper abdominal pain, warming sensation and defecation disturbances, were seen common in case of patients suffering from NAFLD.
   Conclusion: NAFLD is regarded as heterogeneous pathology with variety of clinical findings. It has been experienced that gastrointestinal problems as well as anxiety are most frequently seen in patients suffering from NAFLD.
C1 [Ghumman, Nasim Aslam; Khurrum, Nosheen] Rashid Latif Med Coll, LHR 37Km Ferozpur Rd, Lhr, Pakistan.
   [Qamar, Muhammad Adeel] Sahara Md Coll Narowal, Gastroenterol, Narowal, Pakistan.
   [Khan, Zahid Ahmad] Mohtarma Benazir Bhutto Shaheed Med Coll, Mirpur, Ajk, Pakistan.
   [Ul Mustafa, Zia] Sahara Med Coll Narowal, Narowal, Pakistan.
   [Irshad, Faiza] Anatom M Islam Med & Dent Coll, Gujranwala, Pakistan.
RP Qamar, MA (corresponding author), Sahara Md Coll Narowal, Gastroenterol, Narowal, Pakistan.
EM dradeel176@gmail.com
CR Ahima RS, 2000, ANNU REV PHYSIOL, V62, P413, DOI 10.1146/annurev.physiol.62.1.413
   Browning JD, 2004, HEPATOLOGY, V40, P1387, DOI 10.1002/hep.20466
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   Rafiq N, 2009, CLIN GASTROENTEROL H, V7, P234, DOI 10.1016/j.cgh.2008.11.005
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NR 20
TC 1
Z9 1
U1 0
U2 0
PU LAHORE MEDICAL RESEARCH CENTER LLP
PI LAHORE
PA 590, Karim Block, Allama Iqbal Town, LAHORE, 00000, PAKISTAN
SN 1996-7195
J9 PAK J MED HEALTH SCI
JI Pak. J. Med. Health Sci.
PD SEP
PY 2021
VL 15
IS 9
BP 2371
EP 2372
DI 10.53350/pjmhs211592371
PG 2
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA XN1WE
UT WOS:000729302200075
DA 2025-06-11
ER

PT J
AU Koh, ES
   Jang, SN
   Paik, NJ
   Kim, KW
   Lim, JY
AF Koh, Eun Sil
   Jang, Soong-Nang
   Paik, Nam-Jong
   Kim, Ki Woong
   Lim, Jae-Young
TI Age and gender patterns in associations between lifestyle factors and
   physical performance in older Korean adults
SO ARCHIVES OF GERONTOLOGY AND GERIATRICS
LA English
DT Article
DE Lifestyle; Physical performance; Gender; Older adults
ID LOWER-EXTREMITY FUNCTION; ELDERLY-PEOPLE; FUNCTIONAL DECLINE; BALANCE
   CONFIDENCE; COGNITIVE FUNCTION; METABOLIC SYNDROME; BODY-COMPOSITION;
   SLEEP QUALITY; MENTAL-HEALTH; GAIT SPEED
AB Purpose: To investigate age and gender patterns in associations between lifestyle factors and physical performance in community-dwelling older Korean adults.
   Design and methods: A cross-sectional study was conducted in a population-based sample of an urban area. Randomly sampled older Korean adults (n = 664; mean age, 74.6 years) participated. Data on current physical activity level and doing exercise, social participation and hobbies, smoking status, drinking status, sleep quality, and physical performance were obtained. Binary logistic regression analyses were used to identify the age and gender patterns in associations between various lifestyle factors and physical performance.
   Results: In younger (age <85 years) men, significant predictors of poor physical performance by logistic regression analysis after adjusting for covariates were current physical activity time, doing exercise, and engagement in social activities. In younger women, current physical activity time and sleep quality were related to poor physical performance. In older (age >= 85 years) men, family gatherings were a significant factor. In older women, no lifestyle factor assessed showed a significant relationship with poor physical performance.
   Conclusion: Interventions implemented to modify lifestyle factors need to focus on age and gender subgroups in the elderly population. Lifestyle modification should be emphasised as a targeted treatment program for Korean adults aged <85 years. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
C1 [Paik, Nam-Jong; Lim, Jae-Young] Seoul Natl Univ Bundang Hosp, Seoul Natl Univ Coll Med, Dept Rehabil Med, Songnam 463707, Gyeonggi Do, South Korea.
   [Koh, Eun Sil] Natl Med Ctr, Dept Rehabil Med, Seoul 100799, South Korea.
   [Koh, Eun Sil] Seoul Natl Univ, Coll Med, Dept Biomed Engn, Seoul, South Korea.
   [Jang, Soong-Nang] Chung Ang Univ, Red Cross Coll Nursing, Seoul 156756, South Korea.
   [Kim, Ki Woong] Seoul Natl Univ Bundang Hosp, Seoul Natl Univ Coll Med, Dept Neuropsychiat, Songnam, Gyeonggi Do, South Korea.
   [Kim, Ki Woong] Seoul Natl Univ, Coll Nat Sci, Dept Brain & Cognit Sci, Seoul 151746, South Korea.
C3 Seoul National University (SNU); Seoul National University Hospital;
   National Medical Center - Korea; Seoul National University (SNU); Chung
   Ang University; Seoul National University (SNU); Seoul National
   University Hospital; Seoul National University (SNU)
RP Lim, JY (corresponding author), Seoul Natl Univ Bundang Hosp, Seoul Natl Univ Coll Med, Dept Rehabil Med, 300,Gumi Dong, Songnam 463707, Gyeonggi Do, South Korea.
EM drlim1@snu.ac.kr
RI Paik, Nam-Jong/D-5798-2012; Jang, Soong-nang/AAC-1322-2020; Kim, Ki
   Woong/D-5801-2012
OI Kim, Ki Woong/0000-0002-1103-3858; Lim, Jae-young/0000-0002-9454-0344;
   Paik, Nam-Jong/0000-0002-5193-8678; Jang, Soong-nang/0000-0003-2621-945X
FU Korean Health Technology R&D project, Ministry for Health, Welfare and
   Family Affairs [A092077]; Bio & Medical Technology Development Program
   of the National Research Fund (NRF) - Korean Governement [2011-0030135]
FX This study was supported by a grant from the Korean Health Technology
   R&D project, Ministry for Health, Welfare and Family Affairs (No.
   A092077) and the Bio & Medical Technology Development Program of the
   National Research Fund (NRF) funded by the Korean Governement (No.
   2011-0030135).
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NR 61
TC 10
Z9 10
U1 0
U2 16
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0167-4943
EI 1872-6976
J9 ARCH GERONTOL GERIAT
JI Arch. Gerontol. Geriatr.
PD SEP-OCT
PY 2014
VL 59
IS 2
BP 338
EP 345
DI 10.1016/j.archger.2014.05.002
PG 8
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA AO0RE
UT WOS:000341018300020
PM 24912673
DA 2025-06-11
ER

PT J
AU de la Serna, E
   Baeza, I
   Bargalló, N
   García, C
   Lafuente, A
   Torra, M
   Bernardo, M
AF de la Serna, E.
   Baeza, I.
   Bargallo, N.
   Garcia, C.
   Lafuente, A.
   Torra, M.
   Bernardo, M.
TI Past, present and future of the Clinic schizophrenia research
   group
SO EUROPEAN JOURNAL OF PSYCHIATRY
LA English
DT Article
DE Schizophrenia; Physical health; Neuroimaging; Neuropsychology; Genetics
ID ADOLESCENT 1ST-EPISODE PSYCHOSIS; SPANISH POPULATION; CHILD;
   POLYMORPHISM; DEFICIT; ONSET
AB The currently available diagnostic and therapeutic tools for schizophrenia are unsatisfactory. There is a clear need for new Multidisciplinary treatments and intervention strategies that allow a broad-based approach to the disease. At the Hospital Clinic in Barcelona, the Clinic Schizophrenia Group (Grup Esquizofrenia Clinic, GEC) is actively involved in the following lines of research: physical health, neuroimaging. neuropsychology. the genetic. cellular and molecular bases of psychotic disorders, and child and adolescent mental health.
   In the area of physical health, it has been observed that life expectancy in patients diagnosed with schizophrenia is 20% lower than in the general Population. Sixty per cent of this excess mortality can be attributed to medical diseases: tire risk of diabetes mellitus and metabolic syndrome is twice as high in patients diagnosed with schizophrenia as in the general population. In the area of neuroimaging, research has highlighted the existence of brain Structure anomalies in patients with psychosis or schizophrenia. In cognition, these patients present global alterations in tire areas of memory. attention and executive functions, which range between one and two standard deviations below the mean of tire general population and which have repercussions for the their general functioning. In child onset psychosis, younger age has been associated with greater severity and poor prognosis. Finally, in the area of genetic Studies file research is based on identifying mutations/polymorphisms that influence etiology and pharmacological response in schizophrenic patients.
C1 [Garcia, C.; Bernardo, M.] Hosp Clin Univ, Inst Clin Neurociencies, Dept Psychiat, Barcelona 08036, Spain.
   [de la Serna, E.; Baeza, I.; Bargallo, N.; Garcia, C.; Lafuente, A.; Torra, M.; Bernardo, M.] Minist Sci & Innovat, CIBERSAM, Madrid, Spain.
   [Baeza, I.] Hosp Clin Univ, Inst Clin Neurociencies, Dept Child & Adolescent Psychiat & Psychol, Barcelona 08036, Spain.
   [Bargallo, N.] Hosp Clin Barcelona, CDI, Neuroradiol Sect, Dept Radiol, Barcelona, Spain.
   [Torra, M.] Hosp Clin Barcelona, Biochem & Genet Mol Serv, Barcelona, Spain.
   [Lafuente, A.] Univ Barcelona, Dept Pharmacol, E-08007 Barcelona, Spain.
   [Bernardo, M.] IDIBAPS, Barcelona, Spain.
C3 University of Barcelona; Hospital Clinic de Barcelona; CIBER - Centro de
   Investigacion Biomedica en Red; CIBERSAM; University of Barcelona;
   Hospital Clinic de Barcelona; University of Barcelona; Hospital Clinic
   de Barcelona; University of Barcelona; Hospital Clinic de Barcelona;
   University of Barcelona; University of Barcelona; Hospital Clinic de
   Barcelona; IDIBAPS
RP Bernardo, M (corresponding author), Hosp Clin Univ, Inst Clin Neurociencies, Dept Psychiat, C Villarroel 170, Barcelona 08036, Spain.
EM bernardo@clinic.ub.es
RI Baeza, Inmaculada/GQI-3365-2022; Bargallo, Nuria/G-6854-2016;
   Gil-Lafuente, Anna/O-1087-2013
CR Altshuler LL, 2004, BIOL PSYCHIAT, V56, P560, DOI 10.1016/j.biopsych.2004.08.002
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NR 25
TC 0
Z9 0
U1 0
U2 17
PU EUROPEAN JOURNAL OF PSYCHIATRY
PI ZARAGOZA
PA FAC MED, DEPT PSYCHIATRY PROF A LOBO, DOMINGO MIRAL S-N, 50009 ZARAGOZA,
   SPAIN
SN 0213-6163
J9 EUR J PSYCHIAT
JI Eur. J. Psychiat.
PY 2009
VL 23
SU S
BP 32
EP 37
PG 6
WC Psychiatry
WE Social Science Citation Index (SSCI)
SC Psychiatry
GA 507SI
UT WOS:000270874600006
DA 2025-06-11
ER

PT J
AU Tully, PJ
   Baumeister, H
   Martin, S
   Atlantis, E
   Jenkins, A
   Januszewski, A
   O'Loughlin, P
   Taylor, A
   Wittert, GA
AF Tully, Phillip J.
   Baumeister, Harald
   Martin, Sean
   Atlantis, Evan
   Jenkins, Alicia
   Januszewski, Andrzej
   O'Loughlin, Peter
   Taylor, Anne
   Wittert, Gary A.
CA Florey Adelaide Male Ageing Study
TI Elucidating the Biological Mechanisms Linking Depressive Symptoms With
   Type 2 Diabetes in Men: The Longitudinal Effects of Inflammation,
   Microvascular Dysfunction, and Testosterone
SO PSYCHOSOMATIC MEDICINE
LA English
DT Article
DE depression; diabetes; testosterone; interleukin-6; sE-selectin;
   C-reactive protein; inflammation; longitudinal
ID OLDER-ADULTS; ANTIDEPRESSANT MEDICATION; REPLACEMENT THERAPY; METABOLIC
   SYNDROME; MAJOR DEPRESSION; LIFE-SPAN; HS-CRP; METAANALYSIS;
   ASSOCIATION; HEALTH
AB Objective This prospective cohort study sought to examine key biological measures linking depressive symptoms with Type 2 diabetes, specifically inflammation, microvascular dysfunction, and androgens.
   Methods A cohort of 688 men without diabetes who were 35 years or older were followed up for 5 years. Venous interleukin-6, high-sensitivity C-reactive protein, sE-selectin, endogenous total testosterone, fasting glucose, and glycated hemoglobin (HbA1c) were quantified at baseline and 5 years later. Depressive symptoms were assessed using the Beck Depression Inventory-I, and men were categorized into persistent, remitted, incident, and nondepressed groups (reference). Logistic regression was used to determine odds ratios (ORs) for diabetes adjusted for propensity score calculated from 18 established risk factors.
   Results Diabetes developed in 112 men (16.3% of sample). Persistent depressive symptoms were associated with diabetes (adjusted OR = 2.45, 95% confidence interval [CI] = 1.16-5.20, p = .019). Baseline testosterone (OR = 0.43, 95% CI = 0.22-0.81, p = .01) and follow-up testosterone (OR = 0.51, 95% CI = 0.31-0.84, p = .008) were inversely associated with Type 2 diabetes. Annualized HbA1c was positively associated with annualized change in cognitive Beck Depression Inventory symptoms ( = 0.14, p = .001) and inversely associated with annualized change in testosterone ( = -0.10, p = .014). Annualized change in fasting glucose was associated with sE-selectin ( = 0.12, p < .001) and somatic depressive symptoms ( = -0.12, p = .002).
   Conclusions The findings suggest that lower endogenous total testosterone levels and persistent depressive symptoms were associated with Type 2 diabetes risk and HbA1c in men over a 5-year period.
C1 [Tully, Phillip J.; Martin, Sean; Wittert, Gary A.] Univ Adelaide, Sch Med, Freemasons Fdn, Ctr Mens Hlth, Adelaide, SA, Australia.
   [Tully, Phillip J.; Martin, Sean; Wittert, Gary A.] Univ Adelaide, Sch Med, Discipline Med, Adelaide, SA, Australia.
   [Taylor, Anne] Univ Adelaide, Sch Med, Populat Res & Outcome Studies, Adelaide, SA, Australia.
   [Tully, Phillip J.] INSERM, Epidemiol & Biostat U897, Bordeaux, France.
   [Tully, Phillip J.; Baumeister, Harald] Univ Freiburg, Dept Rehabil Psychol & Psychotherapy, Inst Psychol, Hugstetter Str 55, D-79106 Freiburg, Germany.
   [Baumeister, Harald] Univ Freiburg, Med Psychol & Med Sociol, Fac Med, Hugstetter Str 55, D-79106 Freiburg, Germany.
   [Atlantis, Evan] Univ Western Sydney, Sch Nursing & Midwifery, Sydney, NSW, Australia.
   [Jenkins, Alicia; Januszewski, Andrzej] Univ Sydney, NHMRC Clin Trials Ctr, Sydney, NSW 2006, Australia.
   [O'Loughlin, Peter] Inst Med & Vet Sci Pathol, Adelaide, SA, Australia.
C3 University of Adelaide; University of Adelaide; University of Adelaide;
   Institut National de la Sante et de la Recherche Medicale (Inserm);
   University of Freiburg; University of Freiburg; Western Sydney
   University; University of Sydney; Institute Medical & Veterinary Science
   Australia
RP Tully, PJ (corresponding author), Univ Adelaide, Sch Med, Freemasons Fdn, Ctr Mens Hlth,Discipline Med, Adelaide, SA 5005, Australia.
EM phillip.tully@adelaide.edu.au
RI Atlantis, Evan/ABC-8075-2021; Jenkins, Alicia/N-2482-2015; Januszewski,
   Andrzej/R-4299-2019; wittert, gary/AAE-2398-2019; Tully,
   Phillip/I-6256-2018; Taylor, Anne/F-5708-2010
OI Tully, Phillip/0000-0003-2807-1313; Atlantis, Evan/0000-0001-5877-6141;
   Wittert, Gary/0000-0001-6818-6065; Baumeister,
   Harald/0000-0002-2040-661X; O'Loughlin, Peter/0009-0002-0500-4433;
   Taylor, Anne/0000-0002-4422-7974; Jenkins, Alicia/0000-0003-0583-3717
FU National Health and Medical Research Council of Australia (NHMRC)
   [627227]; NHMRC of Australia (Clinical Overseas Fellowship) [1053578]
FX Gary A. Wittert, Anne Taylor, and Evan Atlantis were supported by the
   National Health and Medical Research Council of Australia (NHMRC;
   Project Grant No. 627227). Phillip J. Tully was supported by the NHMRC
   of Australia (Clinical Overseas Fellowship No. 1053578). The funding
   body had no role in the design and conduct of the study; in the
   collection, analysis, and interpretation of the data; or in the
   preparation, review, or approval of the manuscript. The authors report
   no conflicts of interest.
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NR 55
TC 10
Z9 11
U1 0
U2 16
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0033-3174
EI 1534-7796
J9 PSYCHOSOM MED
JI Psychosom. Med.
PD FEB-MAR
PY 2016
VL 78
IS 2
BP 221
EP 232
DI 10.1097/PSY.0000000000000263
PG 12
WC Psychiatry; Psychology; Psychology, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry; Psychology
GA DD3YU
UT WOS:000369860200010
PM 26575859
DA 2025-06-11
ER

PT J
AU Schiattarella, GG
   Alcaide, P
   Condorelli, G
   Gillette, TG
   Heymans, S
   Jones, EAV
   Kallikourdis, M
   Lichtman, A
   Marelli-Berg, F
   Shah, SJ
   Thorp, EB
   Hill, JA
AF Schiattarella, Gabriele G.
   Alcaide, Pilar
   Condorelli, Gianluigi
   Gillette, Thomas G.
   Heymans, Stephane
   Jones, Elizabeth A. V.
   Kallikourdis, Marinos
   Lichtman, Andrew
   Marelli-Berg, Federica
   Shah, Sanjiv J.
   Thorp, Edward B.
   Hill, Joseph A.
TI Immunometabolic mechanisms of heart failure with preserved ejection
   fraction
SO NATURE CARDIOVASCULAR RESEARCH
LA English
DT Review
ID VISCERAL ADIPOSE-TISSUE; RESIDENT CARDIAC MACROPHAGES; T-CELL;
   SUCCINATE-DEHYDROGENASE; MYOCARDIAL-INFARCTION; INFLAMMATION; OBESITY;
   METABOLISM; PHENOTYPE; HYPERTENSION
AB Heart failure with preserved ejection fraction (HFpEF) is increasing in prevalence worldwide, already accounting for at least half of all cases of heart failure. As most patients with HFpEF are obese with metabolic syndrome, metabolic stress has been implicated in syndrome pathogenesis. Recently, compelling evidence for bidirectional cross-talk between metabolic stress and chronic inflammation has emerged, and alterations in systemic and cardiac immune responses have been shown to participate in HFpEF pathophysiology. Indeed, based on both preclinical and clinical evidence, comorbidity-driven systemic inflammation, coupled with metabolic stress is held to participate in HFpEF pathogenesis. As metabolic alterations impact immune function(s) in HFpEF, major changes in immune cell metabolism are also recognized in HFpEF and in HFpEF-predisposing conditions. Both arms of immunity-innate and adaptive-are implicated in the cardiomyocyte response in HFpEF. Indeed, we submit that cross-talk among adipose tissue, the immune system and the heart represents a critical component of HFpEF pathobiology. Here, we review recent evidence in support of immunometabolic mechanisms as drivers of HFpEF pathogenesis, discuss pivotal biological mechanisms underlying the syndrome, and highlight questions requiring additional inquiry.
C1 [Schiattarella, Gabriele G.] Charite Univ Med Berlin, Dept Cardiol, Ctr Cardiovasc Res CCR, Berlin, Germany.
   [Schiattarella, Gabriele G.] Partner Site Berlin, DZHK German Ctr Cardiovasc Res, Berlin, Germany.
   [Schiattarella, Gabriele G.] Helmholtz Assoc MDC, Translat Approaches Heart Failure & Cardiometabol, Max Delbruck Ctr Mol Med, Berlin, Germany.
   [Schiattarella, Gabriele G.] Univ Naples Federico II, Div Cardiol, Dept Adv Biomed Sci, Naples, Italy.
   [Schiattarella, Gabriele G.; Gillette, Thomas G.; Hill, Joseph A.] Univ Texas Southwestern Med Ctr Dallas, Dept Internal Med Cardiol, Dallas, TX USA.
   [Alcaide, Pilar] Tufts Univ, Dept Immunol, Sch Med, Boston, MA USA.
   [Condorelli, Gianluigi; Kallikourdis, Marinos] Humanitas Univ, Pieve Emanuele, Italy.
   [Condorelli, Gianluigi] Humanitas Res Hosp IRCCS, Cardio Ctr, Rozzano, Italy.
   [Heymans, Stephane; Jones, Elizabeth A. V.] Maastricht Univ, CARIM Sch Cardiovasc Dis, Dept Cardiol, Maastricht, Netherlands.
   [Heymans, Stephane; Jones, Elizabeth A. V.] Katholieke Univ Leuven, Dept Cardiovasc Sci, Ctr Mol & Vasc Biol, Leuven, Belgium.
   [Kallikourdis, Marinos] Humanitas Res Hosp IRCCS, Adapt Immun Lab, Rozzano, Italy.
   [Lichtman, Andrew] Brigham & Womens Hosp, Dept Pathol, Boston, MA USA.
   [Marelli-Berg, Federica] Queen Mary Univ London, Barts & London Sch Med & Dent, William Harvey Res Inst, London, England.
   [Shah, Sanjiv J.] Northwestern Univ, Feinberg Sch Med, Dept Med, Div Cardiol, Chicago, IL USA.
   [Thorp, Edward B.] Northwestern Univ, Feinberg Sch Med, Chicago, IL USA.
   [Hill, Joseph A.] Univ Texas Southwestern Med Ctr Dallas, Dept Mol Biol, Dallas, TX 75390 USA.
C3 Berlin Institute of Health; Free University of Berlin; Humboldt
   University of Berlin; Charite Universitatsmedizin Berlin; German Centre
   for Cardiovascular Research; Helmholtz Association; Max Delbruck Center
   for Molecular Medicine; University of Naples Federico II; University of
   Texas System; University of Texas Southwestern Medical Center Dallas;
   Tufts University; Humanitas University; IRCCS Humanitas Research
   Hospital; Maastricht University; KU Leuven; IRCCS Humanitas Research
   Hospital; Harvard University; Harvard University Medical Affiliates;
   Brigham & Women's Hospital; University of London; Queen Mary University
   London; Northwestern University; Feinberg School of Medicine;
   Northwestern University; Feinberg School of Medicine; University of
   Texas System; University of Texas Southwestern Medical Center Dallas
RP Hill, JA (corresponding author), Univ Texas Southwestern Med Ctr Dallas, Dept Internal Med Cardiol, Dallas, TX USA.; Hill, JA (corresponding author), Univ Texas Southwestern Med Ctr Dallas, Dept Mol Biol, Dallas, TX 75390 USA.
EM joseph.hill@utsouthwestern.edu
RI Gillette, Thomas/IVV-7328-2023; Shah, Sanjiv/AFQ-9480-2022;
   Schiattarella, Gabriele/Z-2624-2019; Schiattarella,
   Gabriele/M-9506-2017; Kallikourdis, Marinos/AAA-5593-2019
OI Shah, Sanjiv/0000-0002-5655-8201; Jones, Elizabeth
   A.V./0000-0002-2006-7064; Schiattarella, Gabriele/0000-0002-7582-7171;
   Kallikourdis, Marinos/0000-0001-9318-3368
FU DZHK (German Centre for Cardiovascular Research); Deutsche
   Forschungsgemeinschaft (German Research Foundation) [SFB-1470-A02,
   IMI2-CARDIATEAM, 821508]; Netherlands Cardiovascular Research
   Initiative; Dutch Cardiovascular Alliance [2015-10, 2017-21]; US
   National Institutes of Health [HL144477, HL122309, HL160273, HL107577,
   HL127028, HL140731, HL149423, HL126012, HL128215, HL120732, HL147933,
   HL155765]; American Heart Association [19TPA34910006]; American Heart
   Association (AHA) [19TPA34910006] Funding Source: American Heart
   Association (AHA)
FX This work was supported by grants from the DZHK (German Centre for
   Cardiovascular Research) to G.G.S.; the Deutsche Forschungsgemeinschaft
   (German Research Foundation; SFB-1470-A02) to G.G.S.; IMI2-CARDIATEAM
   (no. 821508) and the Netherlands Cardiovascular Research Initiative,
   Dutch Cardiovascular Alliance CVON2016-Early HFPEF, 2015-10, CVON
   She-PREDICTS, no. 2017-21 (to S.H.); US National Institutes of Health
   (HL144477 to P.A., HL122309 to E.B.T., HL160273, HL107577, HL127028,
   HL140731, HL149423 to S.J.S. and HL126012, HL128215, HL120732, HL147933
   and HL155765 to J.A.H.) and the American Heart Association
   (19TPA34910006 to J.A.H.). We regret that we were unable to recognize
   all pertinent research in this field and contributions from all
   investigators owing to journal space limitations. All figures were
   created with BioRender.com licensed to G.G.S.
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NR 150
TC 69
Z9 70
U1 3
U2 15
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
EI 2731-0590
J9 NAT CARDIOVASC RES
JI Nat. Cardiovasc. Res.
PD MAR
PY 2022
VL 1
IS 3
BP 211
EP 222
DI 10.1038/s44161-022-00032-w
PG 12
WC Cardiac & Cardiovascular Systems
WE Emerging Sources Citation Index (ESCI)
SC Cardiovascular System & Cardiology
GA Z1U6G
UT WOS:001436845700001
PM 35755006
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Yang, G
   Lee, HE
   Seok, JK
   Kang, HC
   Cho, YY
   Lee, HS
   Lee, JY
AF Yang, Gabsik
   Lee, Hye Eun
   Seok, Jin Kyung
   Kang, Han Chang
   Cho, Yong-Yeon
   Lee, Hye Suk
   Lee, Joo Young
TI RIG-I Deficiency Promotes Obesity-Induced Insulin Resistance
SO PHARMACEUTICALS
LA English
DT Article
DE pattern-recognition receptors; obesity; metabolic syndrome;
   metainflammation; ER stress
ID ENDOPLASMIC-RETICULUM STRESS; IFN-BETA INDUCTION; HIGH-FAT DIET; NLRP3
   INFLAMMASOME; ER STRESS; RNA; OVEREXPRESSION
AB Inflammation and immunity are linked to the onset and development of obesity and metabolic disorders. Pattern recognition receptors (PRRs) are key regulators of inflammation and immunity in response to infection and stress, and they have critical roles in metainflammation. In this study, we investigated whether RIG-I (retinoic acid-inducible gene I)-like receptors were involved in the regulation of obesity-induced metabolic stress in RIG-I knockout (KO) mice fed a high-fat diet (HFD). RIG-I KO mice fed an HFD for 12 weeks showed greater body weight gain, higher fat composition, lower lean body mass, and higher epididymal white adipose tissue (eWAT) weight than WT mice fed HFD. In contrast, body weight gain, fat, and lean mass compositions, and eWAT weight of MDA5 (melanoma differentiation-associated protein 5) KO mice fed HFD were similar to those of WT mice fed a normal diet. RIG-I KO mice fed HFD exhibited more severely impaired glucose tolerance and higher HOMA-IR values than WT mice fed HFD. IFN-beta expression induced by ER stress inducers, tunicamycin and thapsigargin, was abolished in RIG-I-deficient hepatocytes and macrophages, showing that RIG-I is required for ER stress-induced IFN-beta expression. Our results show that RIG-I deficiency promotes obesity and insulin resistance induced by a high-fat diet, presenting a novel role of RIG-I in the development of obesity and metabolic disorders.
C1 [Yang, Gabsik; Lee, Hye Eun; Seok, Jin Kyung; Kang, Han Chang; Cho, Yong-Yeon; Lee, Hye Suk; Lee, Joo Young] Catholic Univ Korea, Coll Pharm, Bucheon 14662, South Korea.
   [Yang, Gabsik] Woosuk Univ, Dept Pharmacol, Coll Korean Med, Jeonju 55338, South Korea.
   [Cho, Yong-Yeon; Lee, Hye Suk; Lee, Joo Young] Catholic Univ Korea, Coll Pharm, BK21FOUR Team, Bucheon 14662, South Korea.
C3 Catholic University of Korea; Woosuk University; Catholic University of
   Korea
RP Lee, JY (corresponding author), Catholic Univ Korea, Coll Pharm, Bucheon 14662, South Korea.; Lee, JY (corresponding author), Catholic Univ Korea, Coll Pharm, BK21FOUR Team, Bucheon 14662, South Korea.
RI Lee, HyeEun/LZG-8579-2025; Kang, Han/I-5999-2019; Cho,
   Yong-Yeon/AAD-4263-2020; Seok, Jin Kyung/D-3574-2019
OI Lee, Joo Young/0000-0002-6020-3040; Yang, Gabsik/0000-0002-9158-6531;
   Kang, Han Chang/0000-0003-0696-1155; Seok, Jin
   Kyung/0000-0003-1034-247X; Cho, Yong-Yeon/0000-0003-1107-2651
FU National Research Foundation of Korea [2019R1A2C2085739,
   NRF-2020R1A4A2002894, NRF-2019R1I1A1A01056377]; Korean government
   (Ministry of Science, ICT and Future Planning)
FX FundingThis study was supported by grants from the National Research
   Foundation of Korea (2019R1A2C2085739, NRF-2020R1A4A2002894, and
   NRF-2019R1I1A1A01056377) funded by the Korean government (Ministry of
   Science, ICT and Future Planning).
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Z9 11
U1 0
U2 10
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 1424-8247
J9 PHARMACEUTICALS-BASE
JI Pharmaceuticals
PD NOV
PY 2021
VL 14
IS 11
AR 1178
DI 10.3390/ph14111178
PG 11
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA XK4CM
UT WOS:000727415800001
PM 34832960
OA Green Published, gold
DA 2025-06-11
ER

PT J
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   Pfabigan, DM
   Han, SH
   Mondillon, L
   Vallet, GT
   Mermillod, M
   Boudet, G
   Obert, P
   Izem, O
   Boirie, Y
   Pereira, B
   Lesage, FX
AF Dutheil, Frederic
   Chaplais, Elodie
   Vilmant, Audrey
   Lanoir, Denise
   Courteix, Daniel
   Duche, Pascale
   Abergel, Armand
   Pfabigan, Daniela M.
   Han, Shihui
   Mondillon, Laurie
   Vallet, Guillaume T.
   Mermillod, Martial
   Boudet, Gil
   Obert, Philippe
   Izem, Omar
   Boirie, Yves
   Pereira, Bruno
   Lesage, Francois-Xavier
TI Effects of a short residential thermal spa program to prevent
   work-related stress/burnout on stress biomarkers: a proof of concept
   study
SO JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
LA English
DT Article
DE Stress; burnout; prevention; heart rate variability; spa bath; work;
   biomarkers
ID HEART-RATE-VARIABILITY; TORONTO-ALEXITHYMIA-SCALE; NEUROTROPHIC FACTOR
   BDNF; JOB DEMAND-CONTROL; CONVERTING-ENZYME; INSERTION/DELETION
   POLYMORPHISM; POSTMENOPAUSAL WOMEN; EUROPEAN ASSOCIATION;
   DEPRESSED-PATIENTS; METABOLIC SYNDROME
AB Objective Work-related stress is a public health issue. Stress has multiple physical and psychological consequences, the most serious of which are increased mortality and cardiovascular morbidity. The ThermStress protocol was designed to offer a short residential thermal spa program for work-related stress prevention that is compatible with a professional context. Methods Participants will be 56 male and female workers aged 18 years or above. All participants will undergo a 6-day residential spa program comprising psychological intervention, physical activity, thermal spa treatment, health education, eating disorder therapy and a follow-up. On six occasions, participants' heart rate variability, cardiac remodelling and function, electrodermal activity, blood markers, anthropometry and body composition, psychology and quality of life will be measured using questionnaires and bone parameters. Results This study protocol reports the planned and ongoing research for this intervention. Discussion The ThermStress protocol has been approved by an institutional ethics committee (ANSM: 2016 A02082 49). It is expected that this proof of concept study will highlight the effect of a short-term specific residential thermal spa program on the prevention of occupational burnout and work-related stress. The findings will be disseminated at several research conferences and in published articles in peer-reviewed journals. (NCT 03536624, 24/05/2018)
C1 [Dutheil, Frederic; Vilmant, Audrey; Boudet, Gil] Univ Clermont Auvergne, Univ Hosp Clermont Ferrand, Prevent & Occupat Med, CHU Clermont Ferrand,CNRS,LaPSCo,WittyFit,Physiol, Clermont Ferrand, France.
   [Dutheil, Frederic; Obert, Philippe] Australian Catholic Univ, Fac Hlth, Sch Exercise Sci, Melbourne, Vic, Australia.
   [Chaplais, Elodie; Courteix, Daniel; Duche, Pascale] Univ Clermont Auvergne, Lab Metab Adaptat Exercise Physiol & Pathol Condi, EA 3533, Clermont Ferrand, France.
   [Chaplais, Elodie] Univ Hosp Clermont Ferrand, Clin Res & Innovat Dept DRCI, CHU Clermont Ferrand, Clermont Ferrand, France.
   [Chaplais, Elodie; Courteix, Daniel] Australian Catholic Univ, Fac Hlth Sci, Sch Exercise Sci, Strathfield, NSW, Australia.
   [Lanoir, Denise] EIPAS Assoc Espace Invest Prevent Accompagnement, Clermont Ferrand, France.
   [Abergel, Armand] Univ Clermont Auvergne, Univ Hosp Clermont Ferrand, CHU Clermont Ferrand, Hepatol Gastroenterol,CNRS,UMR 6284, Clermont Ferrand, France.
   [Pfabigan, Daniela M.; Han, Shihui] Peking Univ, Sch Psychol & Cognit Sci, PKU IDG McGovern Inst Brain Res, Beijing Key Lab Behav & Mental Hlth, Beijing, Peoples R China.
   [Mondillon, Laurie; Vallet, Guillaume T.] Univ Clermont Auvergne, CNRS, LaPSCo, Physiol & Psychosocial Stress, Clermont Ferrand, France.
   [Mermillod, Martial] Grenoble Alpes Univ, CNRS, LNPC, Grenoble, France.
   [Obert, Philippe; Izem, Omar] Inst Univ France, Paris, France.
   [Boirie, Yves] Avignon Univ, Lab Cardiovasc Pharm Ecol LaPEC EA4278, Avignon, France.
   [Pereira, Bruno] Univ Clermont Auvergne, Univ Hosp Clermont Ferrand, CHU Clermont Ferrand, Unit Human Nutr,INRA,CRNH, Clermont Ferrand, France.
   [Lesage, Francois-Xavier] Univ Hosp Clermont Ferrand, Clin Res & Innovat Dept DRCI, Biostat Unit, CHU Clermont Ferrand, Clermont Ferrand, France.
   Monthellier Univ, Lab Epsylon EA 4556, Dynam Human Abil & Hlth Behav, CHU Montpellier,Univ Hosp Montpellier,Occupat Med, Montpellier, France.
C3 Centre National de la Recherche Scientifique (CNRS); Universite Clermont
   Auvergne (UCA); CHU Clermont Ferrand; Australian Catholic University;
   Universite Clermont Auvergne (UCA); Universite Clermont Auvergne (UCA);
   CHU Clermont Ferrand; Australian Catholic University; Australian
   Catholic University - Strathfield Campus; Universite Clermont Auvergne
   (UCA); CHU Clermont Ferrand; Centre National de la Recherche
   Scientifique (CNRS); Peking University; Universite Clermont Auvergne
   (UCA); Centre National de la Recherche Scientifique (CNRS); Centre
   National de la Recherche Scientifique (CNRS); Communaute Universite
   Grenoble Alpes; Universite Grenoble Alpes (UGA); Institut Universitaire
   de France; Avignon Universite; Universite Clermont Auvergne (UCA); CHU
   Clermont Ferrand; INRAE; Universite Clermont Auvergne (UCA); CHU
   Clermont Ferrand; Universite de Montpellier; CHU de Montpellier
RP Dutheil, F (corresponding author), CHU Clermont Ferrand, Prevent & Occupat Med, WittyFit, F-63000 Clermont Ferrand, France.
EM frederic.dutheil@uca.fr
RI Vallet, Guillaume/AAA-9920-2021; Pereira, Bruno/JTT-9628-2023; Dutheil,
   Frederic/O-9707-2014; Pfabigan, Daniela/H-8282-2019; Courteix,
   Daniel/KFS-1216-2024; Pereira, Bruno/ABE-7336-2020; Boirie,
   Yves/KQC-2016-2024
OI Pfabigan, Daniela/0000-0002-4043-1695; Boirie, Yves/0000-0002-3999-1599;
   Courteix, Daniel/0000-0001-6918-714X
FU Region Auvergne Rhone-Alpes by the University Hospital of
   Clermont-Ferrand; European Regional Development Fund (FEDER, Fonds
   Europeen de Developpement Economique et Regional); spa resort of
   Neris-les-Bains
FX The study is integrally funded by the Region Auvergne Rhone-Alpes by the
   University Hospital of Clermont-Ferrand, by the European Regional
   Development Fund (FEDER, Fonds Europeen de Developpement Economique et
   Regional) and by the spa resort of Neris-les-Bains. The funding source
   had no role in the design, conduct, or reporting of the study. The
   authors wish to thank Ms Frederique BRIAT for her commitment to setting
   up and monitoring the program. The authors wish also to thank Mr
   Bertrand BLOYER for promoting a short residential thermal spa program to
   prevent work-related stress/burnout.
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NR 88
TC 5
Z9 5
U1 1
U2 24
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0300-0605
EI 1473-2300
J9 J INT MED RES
JI J. Int. Med. Res.
PD OCT
PY 2019
VL 47
IS 10
BP 5130
EP 5145
AR 0300060519859119
DI 10.1177/0300060519859119
EA SEP 2019
PG 16
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA JG3AA
UT WOS:000491504000001
PM 31510825
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Altuna, ME
   Lelli, SM
   de Viale, LCSM
   Damasco, MC
AF Altuna, Maria Eugenia
   Lelli, Sandra Marcela
   de Viale, Leonor C. San Martin
   Damasco, Maria Cristina
TI Effect of stress on hepatic 11β-hydroxysteroid dehydrogenase activity
   and its influence on carbohydrate metabolism
SO CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
LA English
DT Article
DE hepatic HSD1; PEPCK; stress; carbohydrate metabolism; rat;
   glucocorticoids
ID BETA-HYDROXYSTEROID DEHYDROGENASE; APPARENT MINERALOCORTICOID EXCESS;
   GLUCOCORTICOID ACTION; PYRUVATE-CARBOXYLASE; TYPE-1 ACTIVITY; RAT-LIVER;
   TISSUE; RECEPTOR; GLYCOGEN; OBESITY
AB Stress activates the synthesis and secretion of catecholamines and adrenal glucocorticoids, increasing their circulating levels. In vivo, hepatic 11 beta-hydroxysteroid dehydrogenase I (HSDI) stimulates the shift of 11-dehydrocorticosterone to corticosterone, enhancing active glucocorticoids at tissue level. We Studied the effect of 3 types of stress, I induced by bucogastric overload with 200 mmol/L HCI causing metabolic acidosis (HCI), the second induced by bucogastric overload with 0.45% NaCl (NaCl), and the third induced by Simulated overload (cannula), on the kinetics of hepatic HSDI of rats and their influence on the activity of the gluconeogenic enzyme phosphoenolpyruvate carboxykinase, glycenlia, and glycogen deposition. Compared with Unstressed controls, all types of stress significantly increased HSDI activity (146% cannula, 130% NaCl, and 253% HCI). phosphoenolpyruvate carboxykinase activity (51% cannula. 48% NaCl, and 86% HCI) and glycemia (29% cannula, 30% NaCl, and 41% HCI), but decreased hepatic glycogen (68% cannula, 68% NaCl, and 78% HCI). Owing to these results, We Suggest the following events occur when stress is induced: an increase in hepatic HSDI activity, augmented active glucocorticoid levels, increased gluconeogenesis, and glycemia. Also involved are the multiple events indirectly related to glucocorticoids, which lead to the depletion of hepatic glycogen deposits, thereby contributing to increased glycemia. This new approach shows that stress increments the activity of hepatic HSDI and suggests that this enzyme could be involved in the development of the Metabolic Syndrome.
C1 Univ Buenos Aires, Fac Ciencias Exactas & Nat, Consejo Nacl Invest Cient & Tecn, Lab Esteroides,Dept Quim Biol, RA-1428 Buenos Aires, DF, Argentina.
   Univ Buenos Aires, Lab Disturbios Metab Xenobiot Salud Humana & Med, CONICET, Dept Quim Biol,Fac Ciencias Exactas & Nat, RA-1428 Buenos Aires, DF, Argentina.
C3 University of Buenos Aires; Consejo Nacional de Investigaciones
   Cientificas y Tecnicas (CONICET); Consejo Nacional de Investigaciones
   Cientificas y Tecnicas (CONICET); University of Buenos Aires
RP Damasco, MC (corresponding author), Univ Buenos Aires, Fac Ciencias Exactas & Nat, Consejo Nacl Invest Cient & Tecn, Lab Esteroides,Dept Quim Biol, RA-1428 Buenos Aires, DF, Argentina.
EM cdamasco@qb.fcen.uba.ar
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NR 43
TC 19
Z9 21
U1 0
U2 5
PU CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS
PI OTTAWA
PA 1200 MONTREAL ROAD, BUILDING M-55, OTTAWA, ON K1A 0R6, CANADA
SN 0008-4212
EI 1205-7541
J9 CAN J PHYSIOL PHARM
JI Can. J. Physiol. Pharmacol.
PD OCT
PY 2006
VL 84
IS 10
BP 977
EP 984
DI 10.1139/Y06-046
PG 8
WC Pharmacology & Pharmacy; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Physiology
GA 129LN
UT WOS:000243731100003
PM 17218963
DA 2025-06-11
ER

PT J
AU Carnevale, R
   Nocella, C
   Schiavon, S
   Cammisotto, V
   Cotugno, M
   Forte, M
   Valenti, V
   Marchitti, S
   Vecchio, D
   Zoccai, GB
   Rubattu, S
   Martinelli, O
   Pignatelli, P
   Violi, F
   Volpe, M
   Versaci, F
   Frati, L
   Frati, G
   Sciarretta, S
AF Carnevale, Roberto
   Nocella, Cristina
   Schiavon, Sonia
   Cammisotto, Vittoria
   Cotugno, Maria
   Forte, Maurizio
   Valenti, Valentina
   Marchitti, Simona
   Vecchio, Daniele
   Biondi Zoccai, Giuseppe
   Rubattu, Speranza
   Martinelli, Ombretta
   Pignatelli, Pasquale
   Violi, Francesco
   Volpe, Massimo
   Versaci, Francesco
   Frati, Luigi
   Frati, Giacomo
   Sciarretta, Sebastiano
TI Beneficial effects of a combination of natural product activators of
   autophagy on endothelial cells and platelets
SO BRITISH JOURNAL OF PHARMACOLOGY
LA English
DT Article
DE autophagy; cardiovascular diseases; endothelial cells; oxidative stress;
   platelets
AB Background and Purpose Oxidative stress and insufficient autophagy activity are associated with inflammatory processes and are common features of many cardiovascular diseases (CVDs). We investigated if a combination of natural activators of autophagy could modulate oxidative stress, platelet aggregation and endothelial cell survival and function in response to stress.
   Experimental Approach Ex vivo platelet aggregation and activation, H2O2 production and autophagy were measured in platelets of subjects at high cardiovascular risk, including smokers, patients with metabolic syndrome (MetS) and patients with atrial fibrillation (AF). In vitro, the effects of a mixture of natural pro-autophagy molecules and antioxidants on platelets and human umbilical vein endothelial cells (HUVECs) were evaluated.
   Key Result Autophagy appeared to be inhibited, whereas aggregation was increased in platelets from AF and MetS patients and in smokers, as compared with healthy subjects. Treatment of platelets isolated from these patients with a mixture composed of trehalose, spermidine, catechin and epicatechin (Mix1) or with a mixture composed of trehalose, spermidine and nicotinamide (Mix2), significantly reduced platelet activation and oxidative stress, and increased autophagy, compared with the effect of each compound alone. Similarly, treatment of HUVECs with a combination of these compounds exhibited beneficial effects and increased endothelial cell survival, nitric oxide bioavailability and angiogenesis in response to stress in a potentiated manner.
   Conclusion and Implications A combination of natural activators of autophagy could inhibit platelet activity and oxidative stress and improve endothelial cell survival and function in a potentiated manner representing a useful strategy to reduce the effect of risk factors on CVD occurrence.
C1 [Carnevale, Roberto; Schiavon, Sonia; Vecchio, Daniele; Biondi Zoccai, Giuseppe; Frati, Giacomo] Sapienza Univ Rome, Dept Med Surg Sci & Biotechnol, I-04100 Latina, Italy.
   [Carnevale, Roberto; Biondi Zoccai, Giuseppe; Pignatelli, Pasquale; Violi, Francesco] Mediterranea Cardioctr Napoli, Naples, Italy.
   [Nocella, Cristina; Pignatelli, Pasquale; Violi, Francesco] Sapienza Univ Rome, Dept Clin Internal Anestesiol & Cardiovasc Sci, Rome, Italy.
   [Cammisotto, Vittoria] Sapienza Univ Rome, Dept Gen Surg & Surg Special Paride Stefanini, Rome, Italy.
   [Cotugno, Maria; Forte, Maurizio; Marchitti, Simona; Rubattu, Speranza; Volpe, Massimo; Frati, Luigi; Frati, Giacomo; Sciarretta, Sebastiano] IRCCS Neuromed, Dept Angiocardioneurol, Pozzilli, Italy.
   [Valenti, Valentina; Versaci, Francesco] Osped Santa Maria Goretti, Dept Cardiol, Latina, Italy.
   [Rubattu, Speranza; Volpe, Massimo] Sapienza Univ Rome, Sch Med & Psychol, Clin & Mol Med, Rome, Italy.
   [Martinelli, Ombretta] Sapienza Univ Rome, Dept Paride Stefanini, Unit Vasc Surg, Rome, Italy.
   [Sciarretta, Sebastiano] Sapienza Univ Rome, Ist Pasteur Italia, Fdn Cenci Bolognetti, I-04100 Latina, Italy.
   [Sciarretta, Sebastiano] Sapienza Univ Rome, Dept Med Surg Sci & Biotechnol, I-04100 Latina, Italy.
C3 Sapienza University Rome; Sapienza University Rome; Sapienza University
   Rome; IRCCS Neuromed; Sapienza University Rome; Sapienza University
   Rome; Sapienza University Rome; Fondazione Cenci Bolognetti; Sapienza
   University Rome
RP Carnevale, R (corresponding author), Sapienza Univ Rome, Dept Med Surg Sci & Biotechnol, I-04100 Latina, Italy.
EM roberto.carnevale@uniroma1.it
RI schiavon, sonia/AHE-2959-2022; Carnevale, Roberto/JMC-1138-2023;
   MARTINELLI, OMBRETTA/F-3072-2018; Frati, Giacomo/ABI-7410-2020; Cotugno,
   Maria/ABH-9517-2020; Nocella, Cristina/K-2175-2016; Volpe,
   Massimo/K-5240-2016; Rubattu, Speranza/HTS-6045-2023; Biondi-Zoccai,
   Giuseppe/C-9670-2012; pignatelli, pasquale/K-2116-2016; Forte,
   Maurizio/O-3340-2015
OI schiavon, sonia/0000-0002-5012-5595; Biondi-Zoccai,
   Giuseppe/0000-0001-6103-8510; pignatelli, pasquale/0000-0002-2265-7455;
   Vecchio, Daniele/0000-0003-3859-6869; Forte,
   Maurizio/0000-0003-0739-0534; Valenti, Valentina/0000-0002-6755-9648
CR Alexander SPH, 2019, BRIT J PHARMACOL, V176, pS297, DOI [10.1111/bph.14752, 10.1111/bph.14749]
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NR 35
TC 20
Z9 21
U1 1
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0007-1188
EI 1476-5381
J9 BRIT J PHARMACOL
JI Br. J. Pharmacol.
PD MAY
PY 2021
VL 178
IS 10
BP 2146
EP 2159
DI 10.1111/bph.15399
EA APR 2021
PG 14
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA RV6PQ
UT WOS:000643146800001
PM 33512008
OA Bronze
DA 2025-06-11
ER

PT J
AU Lee, YN
   Mansur, RB
   Brietzke, E
   Carmona, NE
   Subramaniapillai, M
   Pan, ZH
   Shekotikhina, M
   Rosenblat, JD
   Suppes, T
   Cosgrove, VE
   Kramer, NE
   McIntyre, RS
AF Lee, Yena
   Mansur, Rodrigo B.
   Brietzke, Elisa
   Carmona, Nicole E.
   Subramaniapillai, Mehala
   Pan, Zihang
   Shekotikhina, Margarita
   Rosenblat, Joshua D.
   Suppes, Trisha
   Cosgrove, Victoria E.
   Kramer, Nicole E.
   McIntyre, Roger S.
TI Efficacy of adjunctive infliximab vs. placebo in the treatment of
   anhedonia in bipolar I/II depression
SO BRAIN BEHAVIOR AND IMMUNITY
LA English
DT Article
DE Depression; Mood disorders; Bipolar disorder; Anhedonia; Treatment
   efficacy
ID HAMILTON PLEASURE SCALE; NECROSIS-FACTOR-ALPHA; NF-KAPPA-B; CLINICAL
   PHARMACOKINETICS; WAIST CIRCUMFERENCE; INSULIN-RESISTANCE; METABOLIC
   SYNDROME; ADULT OUTPATIENTS; INFLAMMATION; CYTOKINES
AB We investigated the efficacy of tumour necrosis factor (TNF)-alpha antagonist infliximab on a measure of anhedonia amongst individuals with bipolar I/II depression (ClinicalTrials.gov identifier NCT02363738). Adults (ages 18-65) with bipolar I/II disorder currently experiencing a major depressive episode with a higher probability of inflammatory activity (i.e., meeting one or more of the following inflammatory/metabolic criteria: obesity and dyslipidemia/hypertension, daily cigarette smoking, diabetes mellitus, migraine, inflammatory bowel disease, and/or C-reactive protein level of >= 5 mg/L) were enrolled in a double-blind, 12-week clinical trial of adjunctive infliximab (5 mg/kg) and saline control, which were administered at weeks 0, 2, and 6. The primary outcome measure for the present secondary analysis was change in the Snaith-Hamilton Pleasure Scale (SHAPS) total score between placebo- and infliximab-treated subjects from baseline to weeks 6 and 12. Plasma concentrations of TNF-alpha and soluble TNF receptors (sTNFR) 1 and 2 were assessed at weeks 0, 2, 6, and 12. Sixty eligible adults received treatment with infliximab (n = 29) or placebo (n = 31); 47 subjects completed the study (infliximab: n = 21, placebo: n = 26). Overall, infliximab-randomized subjects exhibited significantly larger increases in SHAPS total score, denoting greater reductions in anhedonic symptoms, when compared to placebo-randomized subjects (treatment x time interaction effect: chi(2) = 7.15, df = 2, p = 0.03). Anti-anhedonic efficacy was moderated by baseline plasma levels of TNF-alpha and sTNFR1, but not by changes in TNF-alpha or sTNFR1 concentrations. Baseline and changes in sTNFR2 concentrations did not moderate anti-anhedonic efficacy. Infliximab significantly improved a measure of anhedonia relative to placebo in adults with bipolar I/II depression at week 6; intervention efficacy was not sustained 6 weeks after the final infusion.
C1 [Lee, Yena; McIntyre, Roger S.] Univ Toronto, Inst Med Sci, Toronto, ON, Canada.
   [Lee, Yena; Mansur, Rodrigo B.; Carmona, Nicole E.; Subramaniapillai, Mehala; Pan, Zihang; Shekotikhina, Margarita; Rosenblat, Joshua D.; McIntyre, Roger S.] Univ Hlth Network, Mood Disorders Psychopharmacol Unit, Toronto, ON, Canada.
   [Mansur, Rodrigo B.; Rosenblat, Joshua D.; McIntyre, Roger S.] Univ Toronto, Dept Psychiat, Toronto, ON, Canada.
   [Brietzke, Elisa] Queens Univ, Psychiat, Kingston, ON, Canada.
   [Brietzke, Elisa] Queens Univ, Ctr Neurosci Studies, Kingston, ON, Canada.
   [Carmona, Nicole E.] Ryerson Univ, Dept Psychol, Toronto, ON, Canada.
   [Pan, Zihang; Shekotikhina, Margarita] Univ Ottawa, Dept Psychiat, Ottawa, ON, Canada.
   [Suppes, Trisha; Cosgrove, Victoria E.; Kramer, Nicole E.] Stanford Univ, Sch Med, Dept Psychiat & Behav Sci, Stanford, CA 94305 USA.
   [Suppes, Trisha] VA Palo Alto Hlth Care Syst, Palo Alto, CA USA.
   [McIntyre, Roger S.] Univ Toronto, Dept Pharmacol, Toronto, ON, Canada.
   [McIntyre, Roger S.] Brain & Cognit Discovery Fdn, Toronto, ON, Canada.
C3 University of Toronto; University of Toronto; University Health Network
   Toronto; University of Toronto; Queens University - Canada; Queens
   University - Canada; Toronto Metropolitan University; University of
   Ottawa; Stanford University; US Department of Veterans Affairs; Veterans
   Health Administration (VHA); VA Palo Alto Health Care System; University
   of Toronto
RP McIntyre, RS (corresponding author), Univ Hlth Network, 399 Bathurst St,MP 9-325, Toronto, ON M5T 2S8, Canada.
EM Roger.McIntyre@uhn.ca
RI McIntyre, Roger/AAU-1000-2020; Lee, Yena/L-5505-2019; Mansur,
   Rodrigo/N-7131-2019; Brietzke, Elisa/G-9559-2012
OI Carmona, Nicole/0000-0003-3387-8234; Lee, Yena/0000-0003-0629-9456;
   Rosenblat, Joshua/0000-0002-4773-2191
FU Stanley Medical Research Institute [13T-012]
FX This study was funded by the Stanley Medical Research Institute (Grant
   13T-012).
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NR 77
TC 48
Z9 51
U1 1
U2 10
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0889-1591
EI 1090-2139
J9 BRAIN BEHAV IMMUN
JI Brain Behav. Immun.
PD AUG
PY 2020
VL 88
BP 631
EP 639
DI 10.1016/j.bbi.2020.04.063
PG 9
WC Immunology; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Neurosciences & Neurology; Psychiatry
GA MU5JL
UT WOS:000555709500074
PM 32380271
DA 2025-06-11
ER

PT J
AU Woodward, SH
   Arsenault, NJ
   Voelker, K
   Nguyen, T
   Lynch, J
   Skultety, K
   Mozer, E
   Leskin, GA
   Sheikh, JI
AF Woodward, Steven H.
   Arsenault, Ned J.
   Voelker, Karin
   Nguyen, Tram
   Lynch, Janel
   Skultety, Karyn
   Mozer, Erika
   Leskin, Gregory A.
   Sheikh, Javaid I.
TI Autonomic Activation During Sleep in Posttraumatic Stress Disorder and
   Panic: A Mattress Actigraphic Study
SO BIOLOGICAL PSYCHIATRY
LA English
DT Article
DE Autonomic status; panic disorder; posttraumatic stress disorder; sleep
ID HEART-RATE; BLOOD-PRESSURE; CARDIOVASCULAR ACTIVITY;
   EMERGENCY-DEPARTMENT; METABOLIC SYNDROME; VIETNAM VETERANS; COMBAT
   VETERANS; PTSD; CONSEQUENCES; ASSOCIATION
AB Background: While it has been reported that persons with posttraumatic stress disorder (PTSD) manifest tonic autonomic activation, the literature contains numerous counterexamples. In revisiting the question, this study employed a novel method of mattress actigraphy to unobtrusively estimate heart rate and respiratory sinus arrhythmia over multiple nights of sleep in the home.
   Methods: Sleep cardiac autonomic status was estimated in four diagnostic groups, posttraumatic stress disorder, panic disorder, persons comorbid for both conditions, and control subjects. All 59 participants were community-residing nonveterans screened for sleep apnea and periodic leg movement disorder with polysomnography. Heart rate and respiratory sinus arrhythmia were calculated from the kinetocardiogram signal measured via accelerometers embedded in a mattress topper. Times in bed and asleep were also estimated. Per participant data were obtained from a median of 12 nights.
   Results: Both posttraumatic stress disorder and posttraumatic stress disorder/panic disorder comorbid groups exhibited significantly higher heart rates and lower respiratory sinus arrhythmia magnitudes than panic disorder participants and control subjects. Panic disorder participants were indistinguishable from control subjects. The PTSD-only group exhibited longer times in bed and longertimes presumably asleep than the other three groups.
   Conclusions: In this study, posttraumatic stress disorder, but not panic disorder, was associated with altered cardiac autonomic status during sleep. Among participants meeting criteria for PTSD alone, autonomic activation co-occurred with prolongation of actigraphic sleep.
C1 [Woodward, Steven H.] VA Palo Alto HCS, Natl Ctr PTSD, Disseminat & Training Div, Palo Alto, CA 94304 USA.
   [Voelker, Karin] San Francisco State Univ, Dept Psychol, San Francisco, CA 94132 USA.
   [Nguyen, Tram; Lynch, Janel; Mozer, Erika; Sheikh, Javaid I.] Stanford Univ, Dept Psychiat & Behav Sci, Stanford, CA 94305 USA.
   [Mozer, Erika] Univ Calif San Francisco, Dept Neurol, Memory & Aging Ctr, San Francisco, CA 94143 USA.
   [Skultety, Karyn] Inst Aging, San Francisco, CA USA.
   [Leskin, Gregory A.] Univ Calif Los Angeles, Semel Inst Neurosci & Human Behav, Los Angeles, CA USA.
C3 US Department of Veterans Affairs; Veterans Health Administration (VHA);
   VA Palo Alto Health Care System; California State University System; San
   Francisco State University; Stanford University; University of
   California System; University of California San Francisco; University of
   California System; University of California Los Angeles
RP Woodward, SH (corresponding author), VA Palo Alto HCS, Natl Ctr PTSD, Disseminat & Training Div, 3801 Miranda Ave,Mail Code 334 PTSD, Palo Alto, CA 94304 USA.
EM steve.woodward@va.gov
RI Nguyen, Tram/MGU-5521-2025
OI Sheikh, Javaid/0000-0002-5762-4186
FU NIMH NIH HHS [R01 MH064724, MH64724] Funding Source: Medline
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NR 36
TC 48
Z9 57
U1 0
U2 9
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0006-3223
EI 1873-2402
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD JUL 1
PY 2009
VL 66
IS 1
BP 41
EP 46
DI 10.1016/j.biopsych.2009.01.005
PG 6
WC Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA 463YK
UT WOS:000267469900007
PM 19232575
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Panten, J
   Stone, RC
   Baker, J
AF Panten, Josefine
   Stone, Rachael C.
   Baker, Joseph
TI Balance is key: Exploring the impact of daily self-reported physical
   activity and sedentary behaviours on the subjective health status of
   older adults
SO PREVENTIVE MEDICINE
LA English
DT Article
DE Sedentary lifestyle; Leisure activities; Health promotion; Recreation;
   Physical activity; Aging; Subjective health status
ID TELEVISION VIEWING TIME; METABOLIC SYNDROME; SLEEP DURATION;
   CARDIOVASCULAR-DISEASE; UNITED-STATES; SITTING TIME; RATED HEALTH;
   ASSOCIATIONS; MORTALITY; US
AB Research has identified physical activity and sedentary behaviours as independent predictors of successful aging; however, few studies have explored interactions between these constructs in relation to older adult health. The present study utilized data from the General Social Survey (Cycle 24) to calculate proportion of time engaging in sedentary and physically active behaviours during waking hours, and examined its impact on self-rated health and physical health limitations (e.g., difficulty walking) in older adults (N = 3557; >= 65 years). Results suggest this proportion has a significant impact on three health measures; as proportion of daily minutes becomes more physically active or less sedentary, the better one's health status tends to be. Specifically, the proportion was positively associated with self-rated general health (ORPoor-Excellent = 17.57; p < 0.05) and self-rated mental health (ORPoor-Excellent = 4.68; p < 0.05). Reporting health limitations was less likely to occur with increases in the proportion (OR = 0.30; p < 0.05). These findings suggest the need for further examining daily time-balances between physical activity and sedentary behaviours in order to create a comprehensive health profile for older adults. (C) 2017 Elsevier Inc. All rights reserved.
C1 [Panten, Josefine] Carl von Ossietzky Univ Oldenburg, Inst Sport Sci, Oldenburg, Germany.
   [Stone, Rachael C.; Baker, Joseph] York Univ, Sch Kinesiol & Hlth Sci, 4700 Keele St, Toronto, ON M3J 1P3, Canada.
C3 Carl von Ossietzky Universitat Oldenburg; York University - Canada
RP Stone, RC (corresponding author), York Univ, Sch Kinesiol & Hlth Sci, 4700 Keele St, Toronto, ON M3J 1P3, Canada.
EM raystone@yorku.ca
RI Baker, Joseph/J-6164-2014
OI Baker, Joseph/0000-0002-5686-1737
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NR 51
TC 7
Z9 11
U1 0
U2 28
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0091-7435
EI 1096-0260
J9 PREV MED
JI Prev. Med.
PD AUG
PY 2017
VL 101
BP 109
EP 116
DI 10.1016/j.ypmed.2017.05.020
PG 8
WC Public, Environmental & Occupational Health; Medicine, General &
   Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; General & Internal Medicine
GA FA8EH
UT WOS:000405678500019
PM 28579500
DA 2025-06-11
ER

PT J
AU Cao, X
   Yu, HX
   Quan, Y
   Qin, J
   Zhao, YH
   Yang, XC
   Gao, SY
AF Cao, Xia
   Yu, Huixin
   Quan, Yu
   Qin, Jing
   Zhao, Yuhong
   Yang, Xiaochun
   Gao, Shanyan
TI An overview of environmental risk factors for type 2 diabetes research
   using network science tools
SO DIGITAL HEALTH
LA English
DT Article
DE Bibliometric analysis; environmental factors; evolutionary analysis;
   knowledge mapping; social network analysis; type 2 diabetes
ID PERSISTENT ORGANIC POLLUTANTS; INDIVIDUALS; MELLITUS; HEALTH
AB Objective Current studies lack a comprehensive understanding of the environmental factors influencing type 2 diabetes, hindering an in-depth grasp of the overall etiology. To address this gap, we utilized network science tools to highlight research trends, knowledge structures, and intricate relationships among factors, offering a new perspective for a profound understanding of the etiology.Methods The Web of Science database was employed to retrieve documents relevant to environmental risk factors in type 2 diabetes from 2012 to 2024. Bibliometric analysis using Microsoft Excel and OriginPro provided a detailed scientific production profile, including articles, journals, countries, and authors. Co-occurrence analysis was employed to determine the collaboration state and knowledge structures, utilizing social network tools such as Gephi, Tableau, and R Studio. Additionally, theme evolutionary analysis was conducted using SciMAT to offer insights into research trends.Results The publications and themes related to environmental factors in type 2 diabetes have consistently risen, shaping a well-established research domain. Lifestyle environmental factors, particularly diet and nutrition, stand out as the most represented and rapidly growing topics. Key focal hotspots include sedentary and digital behavior, PM2.5, ethnicity and socioeconomic status, traffic and greenspace, and depression. The theme evolutionary analysis revealed three distinct paths: (1) oxidative stress-air pollutants-PM2.5-air pollutants; (2) calcium-metabolic syndrome-cardiovascular disease; and (3) polychlorinated biphenyls (PCBs)-persistent organic pollutants (POPs)-obesity.Conclusions Digital behavior signifies a novel approach for preventing and managing type 2 diabetes. The influence of PM2.5 and calcium on oxidative stress and abnormal vascular contraction is intricately linked to microvascular diabetes complications. The transition from PCBs and POPs to obesity underscores the disruption of endocrine function by chemicals, elevating the risk of diabetes. Future studies should explore the connections between environmental factors, microvascular complications, and long-term outcomes in diabetes.
C1 [Cao, Xia; Yu, Huixin; Quan, Yu] China Med Univ, Shengjing Hosp, Dept Data Ctr, Shenyang, Liaoning, Peoples R China.
   [Cao, Xia] Northeastern Univ, Sch Comp Sci & Engn, Shenyang, Liaoning, Peoples R China.
   [Quan, Yu] China Med Univ, Shengjing Hosp, Dept Comp Ctr, Shenyang, Liaoning, Peoples R China.
   [Qin, Jing] Shenyang Med Coll, Shenyang, Liaoning, Peoples R China.
   [Zhao, Yuhong] China Med Univ, Shengjing Hosp, Dept Clin Epidemiol, 36 Sanhao St, Shenyang 110004, Liaoning, Peoples R China.
   [Yang, Xiaochun] Northeastern Univ, Software Coll, 195 Chuangxin Rd, Shenyang 110169, Liaoning, Peoples R China.
   [Gao, Shanyan] China Med Univ, Shengjing Hosp, Res Ctr, Dept Clin, 39 Huaxiang Rd, Shenyang 110022, Liaoning, Peoples R China.
C3 China Medical University; Northeastern University - China; China Medical
   University; Shenyang Medical College; China Medical University;
   Northeastern University - China; China Medical University
RP Zhao, YH (corresponding author), China Med Univ, Shengjing Hosp, Dept Clin Epidemiol, 36 Sanhao St, Shenyang 110004, Liaoning, Peoples R China.; Yang, XC (corresponding author), Northeastern Univ, Software Coll, 195 Chuangxin Rd, Shenyang 110169, Liaoning, Peoples R China.; Gao, SY (corresponding author), China Med Univ, Shengjing Hosp, Res Ctr, Dept Clin, 39 Huaxiang Rd, Shenyang 110022, Liaoning, Peoples R China.
EM zhaoyuhong@sj-hospital.org; yangxc@mail.neu.edu.cn;
   gaosy@sj-hospital.org
FU National Key R&D Program of China [2023YFC3604600]; Doctoral Start-up
   Foundation of Liaoning Province [2021-BS-120]; The 345 Talent Project of
   Shengjing Hospital of China Medical University [M0334]
FX The authors disclosed receipt of the following financial support for the
   research, authorship, and/or publication of this article: This work was
   supported by the National Key R&D Program of China (2023YFC3604600), the
   Doctoral Start-up Foundation of Liaoning Province (2021-BS-120), the 345
   Talent Project of Shengjing Hospital of China Medical University
   (M0334).
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NR 52
TC 0
Z9 0
U1 4
U2 10
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 2055-2076
J9 DIGIT HEALTH
JI Digit. Health
PY 2024
VL 10
AR 20552076241271722
DI 10.1177/20552076241271722
PG 18
WC Health Care Sciences & Services; Health Policy & Services; Public,
   Environmental & Occupational Health; Medical Informatics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services; Public, Environmental & Occupational
   Health; Medical Informatics
GA A8N1A
UT WOS:001285040000001
PM 39114112
OA gold
DA 2025-06-11
ER

PT J
AU Brito-Monzani, JD
   Sanches, IC
   Bernardes, N
   Ponciano, K
   Moraes-Silva, IC
   Irigoyen, MC
   Llesuy, S
   De Angelis, K
AF Brito-Monzani, Janaina de O.
   Sanches, Iris Callado
   Bernardes, Nathalia
   Ponciano, Katia
   Moraes-Silva, Ivana C.
   Irigoyen, Maria-Claudia
   Llesuy, Susana
   De Angelis, Katia
TI Hypertension induces additional cardiometabolic impairments and
   attenuates aerobic exercise training adaptations in fructose-fed
   ovariectomized rats
SO HYPERTENSION RESEARCH
LA English
DT Article
DE autonomic nervous system; exercise training; menopause; metabolic
   syndrome
ID OXIDATIVE STRESS; METABOLIC SYNDROME; BAROREFLEX SENSITIVITY;
   BARORECEPTOR DYSFUNCTION; AUTONOMIC DYSFUNCTION; ENDOTHELIAL FUNCTION;
   INSULIN-RESISTANCE; EXPERIMENTAL-MODEL; BLOOD-PRESSURE; NITRIC-OXIDE
AB We tested whether hypertension favors the development of additional cardiometabolic changes in fructose-fed ovariectomized rats and how it affects aerobic exercise training (ET) effects. All rats received fructose in drinking water (10%) beginning at weaning, were ovariectomized at 10 weeks of age and divided into the normotensive sedentary (NFOS) and trained (NFOT) and hypertensive sedentary (HFOS) and trained (HFOT) groups. ET was performed on a treadmill. Arterial pressure (AP) was directly recorded; heart rate and AP variabilities were analyzed. Lipoperoxidation (LPO) and antioxidant enzyme levels were measured in the left ventricle. In addition to increased AP levels, when compared with the NFOS group, the hypertensive groups had resting tachycardia, a reduction of 29% in the pulse interval variance (VAR-PI), 19% in RMSSD (root mean square of successive differences, a cardiac parasympathetic index) and 53% in the a-index (spontaneous baroreflex), while the systolic AP variance (VAR-SAP) and its low-frequency band (LF-SAP) were sharply increased. ET did not alter AP levels. Even in the presence of hypertension, ET induced resting bradycardia, decreases of 33% in VAR-SAP and 49% in LF-SAP, and an increase of more than 60% in VAR-PI and the a-index. However, some of these parameters were still impaired relative to those of normotensive rats. LPO was reduced and catalase was increased in both trained groups, with no difference between the normotensive and hypertensive groups. Negative correlations were obtained between LPO and RMSSD (r=-0.60, Po0.05) and a-index (r=-0.63, Po0.05). In conclusion, hypertension augmented the dysfunctions in fructose-fed ovariectomized rats and attenuated metabolic aerobic ET benefits. These changes may be related to cardiovascular autonomic and oxidative stress alterations.
C1 [Brito-Monzani, Janaina de O.] Univ Fed Maranhao, Lab Cardiovasc Adaptat Exercise LACORE, Sao Luis, Brazil.
   [Sanches, Iris Callado; Ponciano, Katia] Univ Sao Judas Tadeu, Sao Paulo, Brazil.
   [Bernardes, Nathalia; De Angelis, Katia] Univ Nove Julho UNINOVE, Lab Translat Physiol, Sci Rehabil Program, Rua Vergueiro 235-249-2 Subsolo Mestrado, BR-01504001 Sao Paulo, Brazil.
   [Moraes-Silva, Ivana C.; Irigoyen, Maria-Claudia] Univ Sao Paulo, Med Sch, Heart Inst InCor, Hypertens Unit, Sao Paulo, Brazil.
   [Llesuy, Susana] Univ Buenos Aires, Fac Farm & Bioquim, Buenos Aires, DF, Argentina.
C3 Universidade Federal do Maranhao; Universidade Sao Judas Tadeu;
   Universidade Nove de Julho; Universidade de Sao Paulo; University of
   Buenos Aires
RP De Angelis, K (corresponding author), Univ Nove Julho UNINOVE, Lab Translat Physiol, Sci Rehabil Program, Rua Vergueiro 235-249-2 Subsolo Mestrado, BR-01504001 Sao Paulo, Brazil.
EM prof.kangelis@uni9.pro.br
RI Moraes-Silva, Ivana/K-2557-2019; Bernardes, Nathalia/L-7460-2015;
   Sanches, Iris Callado/D-5079-2013; Ponciano, Katia Regina/V-2899-2018;
   Irigoyen, maria Claudia/N-6880-2014; DE ANGELIS, KATIA/I-6098-2016
OI Sanches, Iris Callado/0000-0001-6195-4340; Ponciano, Katia
   Regina/0000-0002-7274-9606; Francisca Llesuy,
   Susana/0000-0001-6818-051X; Irigoyen, maria Claudia/0000-0003-2097-3662;
   DE ANGELIS, KATIA/0000-0002-3640-9049
FU Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior
   (CAPES-PROSUP) [CAPES-PVE 88881.062178/2014-01]; CNPq [563961/2010-4,
   479766/2011-8, 457200/2014-6]; FAPESP [2010/17188-4, 2012/20141-5,
   2015/11223-6]; CNPq-BPQ fellowships; Fundacao de Amparo a Pesquisa do
   Estado de Sao Paulo (FAPESP) [10/17188-4] Funding Source: FAPESP
FX We acknowledge the financial support of Coordenacao de Aperfeicoamento
   de Pessoal de Nivel Superior (CAPES-PROSUP, CAPES-PVE
   88881.062178/2014-01), CNPq (563961/2010-4, 479766/2011-8,
   457200/2014-6) and FAPESP (2010/17188-4, 2012/20141-5, 2015/11223-6).
   KDA and MCI are recipients of CNPq-BPQ fellowships.
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NR 55
TC 4
Z9 4
U1 0
U2 11
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0916-9636
EI 1348-4214
J9 HYPERTENS RES
JI Hypertens. Res.
PD FEB
PY 2018
VL 41
IS 2
BP 88
EP 95
DI 10.1038/hr.2017.94
PG 8
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA FV0EZ
UT WOS:000424230100002
PM 29093566
DA 2025-06-11
ER

PT J
AU Wang, XQ
   Ren, XH
   Kou, WJ
   Li, Y
   Hui, ZZ
   Sun, JR
   Wang, MX
AF Wang, Xiao-Qin
   Ren, Xiao-Han
   Kou, Wen-Jing
   Li, Yang
   Hui, Zhao-Zhao
   Sun, Jia-Ru
   Wang, Ming-Xu
TI Gender differences in the relationships between housework and metabolic
   markers: a longitudinal cohort study in China
SO BMC PUBLIC HEALTH
LA English
DT Article
DE Housework; Metabolic Syndrome; Stress; Gender Differences
ID PHYSICAL-ACTIVITY; DECISION-MAKING; CHRONIC STRESS; HEALTH; WOMEN;
   LEISURE; TIME; ASSOCIATION; MORTALITY; MEN
AB Background Metabolic syndrome has become a major health threat throughout the world, but there are few studies that focus on the effects of housework on human metabolism. This study explores the association between housework and metabolic markers and examines whether there are gender differences in the relationship of housework intensity on these markers. Methods We obtained data for 2,624 participants from the China Health and Nutrition Survey and used binary logistic regression to analyze the association between housework and metabolic markers (triglycerides, high- and low-density lipoprotein cholesterol, hemoglobin, blood glucose, cholesterol, and blood pressure). Results We observed no association between housework and metabolic markers for men. However, we find that women who engaged in housework had a higher risk of triglycerides than those who did not (OR=1.16, 95% CI: 1.16, 4.25). Compared with low-intensity, we also find that women who performed moderate- and high-housework intensity had a higher risk of triglycerides (moderate-intensity: OR=1.78, 95% CI: 1.14, 2.78; high-intensity: OR=1.91, 95% CI: 1.22, 2.98), MetS (OR=1.54, 95% CI: 0.98, 2.43; OR=1.68, 95% CI: 1.07, 2.66), pre-hypertension (OR=1.68, 95% CI: 1.08, 2.62; OR=1.63, 95% CI: 1.04, 2.55), and obesity (OR=1.65, 95% CI: 1.01, 2.70; OR=1.66, 95% CI: 1.01, 2.72). Conclusion In women, we find that housework is positively associated with the metabolic markers, triglycerides, MetS, and pre-hypertension. However, we did not find evidence that this relationship exists in men, f or any biomarkers we considered. One possible explanation is that people who engage in high-intensity housework are more stressed and sleep less, which could be a mechanism by which housework becomes associated with metabolic disease.
C1 [Wang, Xiao-Qin; Ren, Xiao-Han; Kou, Wen-Jing; Hui, Zhao-Zhao; Sun, Jia-Ru; Wang, Ming-Xu] Xi An Jiao Tong Univ, Hlth Sci Ctr, Sch Publ Hlth, 76 Yanta West Rd, Xian 710061, Peoples R China.
   [Li, Yang] Air Force Med Univ, Dept Nursing, Xian, Peoples R China.
C3 Xi'an Jiaotong University; Air Force Medical University
RP Wang, MX (corresponding author), Xi An Jiao Tong Univ, Hlth Sci Ctr, Sch Publ Hlth, 76 Yanta West Rd, Xian 710061, Peoples R China.
EM wangmx601@mail.xjtu.edu.cn
RI HUI, Zhaozhao/AAW-2085-2021
FU National Institute of Nutrition and Food Safety; China Center for
   Disease Control and Prevention; Carolina Population Center; University
   of North Carolina at Chapel Hill; NIH [R01HD30880, DK056350,
   R01-HD38700]; Fogarty International Center, NIH
FX This research uses data from the China Health and Nutrition Survey
   (CHNS). We thank the National Institute of Nutrition and Food Safety,
   the China Center for Disease Control and Prevention, the Carolina
   Population Center, the University of North Carolina at Chapel Hill, the
   NIH (R01HD30880, DK056350, and R01-HD38700), and the Fogarty
   International Center, NIH for financial support for the CHNS data
   collection and analysis files from 1989 to 2015 and the China-Japan
   Friendship Hospital. The authors thank AiMi Academic Services
   (www.aimieditor.com) for the English language editing and review
   services.
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NR 41
TC 5
Z9 5
U1 6
U2 17
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2458
J9 BMC PUBLIC HEALTH
JI BMC Public Health
PD FEB 17
PY 2022
VL 22
IS 1
AR 336
DI 10.1186/s12889-022-12566-6
PG 11
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA ZC2OC
UT WOS:000757364800005
PM 35177008
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Sajid, MR
   Muhammad, N
   Zakaria, R
   Shahbaz, A
   Nauman, A
AF Sajid, Mirza Rizwan
   Muhammad, Noryanti
   Zakaria, Roslinazairimah
   Shahbaz, Ahmad
   Nauman, Ahmad
TI Associated Factors of Cardiovascular Diseases in Pakistan: Assessment of
   Path Analyses Using Warp Partial Least Squares Estimation
SO PAKISTAN JOURNAL OF STATISTICS AND OPERATION RESEARCH
LA English
DT Article
DE Cardiovascular Diseases; Risk Factors; Path Analyses; Partial Least
   Squares; Warp 3 Algorithm; Mediation
ID METABOLIC SYNDROME; RISK-FACTORS; PHYSICAL-ACTIVITY; HEALTH; LIFE;
   QUESTIONNAIRE; COMPONENTS; SMOKING; STRESS; INCOME
AB Demographic and socio-economic (SE) factors are associated with modifiable, clinical factors and cardiovascular disease (CVDs). However, the inclusion of mediators in these relationships creates complex pathways which extend the roles of factors within the model. The traditional hierarchal logistic regression (HLR) is unable to estimate the transmittal effects of factors through different layers of factors of CVDs. The study aims to simultaneously estimate and validate the probable linear and non-linear relationships among factors of CVDs considering potential mediators. Four hundred sixty participants (312 males and 148 females) were selected through systematic sampling in this sex-matched case control (1:1 ratio) study conducted in the largest Cardiac Center of Pakistan. The information on demographic, SE, modifiable and clinical factors of CVDs was recorded. Warp partial least squares (PLS) based on warp 3 algorithm was used to estimate the simultaneous linear and non-linear path coefficients of the proposed model of study. The study found that demographic and SE factors played a significant role in shaping the modifiable factors which further transmit their impact to CVDs. However, this transmitted impact of modifiable factors on CVDs was mediated through metabolic syndrome abnormalities (MSA) except self-reported subjective stress (SSS). Sleep satisfaction and negative dietary habits were the mediators between the relationship of SSS and MSA. Physical activity is the strongest factor associated with CVDs status. The proposed path analyses, verifying the mediation role of MSA in the pathways of relationships which would help in identifying the risky group of population and guide in formulating the health promotion policies for the reduction of CVDs burden. Further, Warp 3 algorithm is the better option to estimate complex models containing linear and non-linear relationship in the same model.
C1 [Sajid, Mirza Rizwan; Muhammad, Noryanti; Zakaria, Roslinazairimah] Univ Malaysia Pahang, Coll Comp & Appl Sci, Ctr Math Sci, Kuantan 26300, Pahang Darul Ma, Malaysia.
   [Shahbaz, Ahmad; Nauman, Ahmad] Punjab Inst Cardiol, Lahore, Pakistan.
C3 Universiti Malaysia Pahang Al-Sultan Abdullah (UMPSA)
RP Muhammad, N (corresponding author), Univ Malaysia Pahang, Coll Comp & Appl Sci, Ctr Math Sci, Kuantan 26300, Pahang Darul Ma, Malaysia.
EM mirzarizwansajid@gmail.com; noryanti@ump.edu.my;
   roslinazairimah@ump.edu.my; drahmadshahbaz@gmail.com;
   ahmadnoeman@gmail.com
RI Muhammad, Noryanti/AAW-3081-2020; Noeman, Ahmad/AAD-8642-2019; Sajid,
   Rizwan/AAW-7510-2021; Muhammad, Noryanti/B-5943-2018
OI Sajid, Mirza Rizwan/0000-0002-0358-2195; Noeman,
   Ahmad/0000-0002-6271-4151; Muhammad, Noryanti/0000-0002-6112-3720
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NR 55
TC 11
Z9 11
U1 0
U2 1
PU UNIV PUNJAB
PI LAHORE
PA INST GEOL, QUID-E-AZAM CAMPUS, PO BOX NO 54590, LAHORE, 00000, PAKISTAN
SN 1816-2711
EI 2220-5810
J9 PAK J STAT OPER RES
JI Pak. J. Stat. Oper. Res.
PD JUN
PY 2020
VL 16
IS 2
BP 265
EP 277
DI 10.18187/pjsor.v16i2.3075
PG 13
WC Statistics & Probability
WE Emerging Sources Citation Index (ESCI)
SC Mathematics
GA LX7IP
UT WOS:000540001300005
OA gold
DA 2025-06-11
ER

PT J
AU Iffiú-Soltész, Z
   Wanecq, E
   Lomba, A
   Portillo, MP
   Pellati, F
   Szöko, É
   Bour, S
   Woodley, J
   Milagro, FI
   Martinez, JA
   Valet, P
   Carpéné, C
AF Iffiu-Soltesz, Zsuzsa
   Wanecq, Estelle
   Lomba, Almudena
   Portillo, Maria P.
   Pellati, Federica
   Szoko, Eva
   Bour, Sandy
   Woodley, John
   Milagro, Fermin I.
   Alfredo Martinez, J.
   Valet, Philippe
   Carpene, Christian
TI Chronic benzylamine administration in the drinking water improves
   glucose tolerance, reduces body weight gain and circulating cholesterol
   in high-fat diet-fed mice
SO PHARMACOLOGICAL RESEARCH
LA English
DT Article
DE Adipose tissue; Semicarbazide-sensitive amine oxidase; Monoamine
   oxidase; Antidiabetic; Obesity
ID SENSITIVE AMINE OXIDASE; INDUCED DIABETIC-RATS; MONOAMINE-OXIDASE;
   HYDROGEN-PEROXIDE; OXIDATIVE STRESS; HUMAN ADIPOCYTES; KV1.1 CHANNELS;
   CELL LIPOLYSIS; URIC-ACID; IN-VITRO
AB Benzylamine is found in Moringa oleifera, a plant used to treat diabetes in traditional medicine. In mammals, benzylamine is metabolized by semicarbazide-sensitive amine oxidase (SSAO) to benzaldehyde and hydrogen peroxide. This latter product has insulin-mimicking action, and is involved in the effects of benzylamine on human adipocytes: stimulation of glucose transport and inhibition of lipolysis. This study examined whether chronic, oral administration of benzylamine could improve glucose tolerance and the circulating lipid profile without increasing oxidative stress in overweight and pre-diabetic mice. The benzylamine diffusion across the intestine was verified using everted gut sacs. Then, glucose handling and metabolic markers were measured in mice rendered insulin-resistant when fed a high-fat diet (HFD) and receiving or not benzylamine in their drinking water (3600 mu mol/(kg day)) for 17 weeks. HFD-benzylamine mice showed lower body weight gain, fasting blood glucose, total plasma cholesterol and hyperglycaemic response to glucose load when compared to HFD control. In adipocytes, insulin-induced activation of glucose transport and inhibition of lipolysis remained unchanged. In aorta, benzylamine treatment partially restored the nitrite levels that were reduced by HFD. In liver, lipid peroxidation markers were reduced. Resistin and uric acid, surrogate plasma markers of metabolic syndrome, were decreased. In spite of the putative deleterious nature of the hydrogen peroxide generated during amine oxidation, and in agreement with its in vitro insulin-like actions found on adipocytes, the SSAO-substrate benzylamine could be considered as a potential oral agent to treat metabolic syndrome. (C) 2010 Elsevier Ltd. All rights reserved.
C1 [Iffiu-Soltesz, Zsuzsa; Wanecq, Estelle; Bour, Sandy; Valet, Philippe; Carpene, Christian] IFR 150, Inst Med Mol Rangueil, U858, INSERM, Toulouse, France.
   [Iffiu-Soltesz, Zsuzsa; Szoko, Eva] Semmelweis Univ, Dept Pharmacodynam, Budapest, Hungary.
   [Lomba, Almudena; Milagro, Fermin I.; Alfredo Martinez, J.] Univ Navarra, Dept Nutr & Food Sci Physiol & Toxicol, E-31080 Pamplona, Spain.
   [Portillo, Maria P.] Univ Basque Country, Dept Nutr & Food Sci, Vitoria, Spain.
   [Pellati, Federica] Univ Modena & Reggio Emilia, Dept Pharmaceut Sci, Modena, Italy.
   [Woodley, John] Biopharmtech, Toulouse, France.
C3 Institut National de la Sante et de la Recherche Medicale (Inserm); CHU
   de Toulouse; Semmelweis University; University of Navarra; University of
   Basque Country; Universita di Modena e Reggio Emilia
RP Carpéné, C (corresponding author), CHU Rangueil, Inst Med Mol Rangueil I2MR, U858, INSERM,Equipe 3, Bat L4,BP 84225, F-31432 Toulouse 4, France.
EM christian.carpene@inserm.fr
RI Woodley, John/P-9960-2016; Milagro, Fermin/F-2315-2015; Szökő,
   Eva/O-1829-2017; Carpéné, Christian/S-3279-2019; Portillo,
   Maria/ABH-2374-2020; Martinez Hernandez, J Alfredo/K-8709-2014; Valet,
   Philippe/N-7472-2017; Pellati, Federica/H-5846-2015
OI Szoko, Eva/0000-0003-1464-6403; Martinez Hernandez, J
   Alfredo/0000-0001-5218-6941; PORTILLO BAQUEDANO, MARIA
   PUY/0000-0003-2290-592X; Valet, Philippe/0000-0001-6520-7393; Milagro,
   Fermin I./0000-0002-3228-9916; Pellati, Federica/0000-0002-9822-6862
FU Communaute de Travail des Pyrenees [05018677]; Hungarian Scientific
   Research Fund [OTKA K63415]; Programme Balaton [14117SA]; Hungarian
   National Office of Research and Technology [OMFB-00491/2007]
FX The authors express gratitude to D. Prevot and A. Desquesnes for
   biochemical analyses at ANEXPLO platform, Y. Barreira and the staff of
   animal unit of I2MR, Toulouse, for invaluable help. The expertise of S.
   Benvenuti regarding amine chromatography is gratefully acknowledged.
   This work was partly supported by an R&D grant from the "Communaute de
   Travail des Pyrenees" (project MP #05018677), the Hungarian Scientific
   Research Fund (OTKA K63415) and by "Programme Balaton" (project Egide
   #14117SA and Hungarian National Office of Research and Technology
   OMFB-00491/2007) for Franco-Spanish and Franco-Hungarian exchanges,
   respectively.
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NR 41
TC 39
Z9 42
U1 0
U2 28
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 1043-6618
J9 PHARMACOL RES
JI Pharmacol. Res.
PD APR
PY 2010
VL 61
IS 4
BP 355
EP 363
DI 10.1016/j.phrs.2009.12.014
PG 9
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 582FH
UT WOS:000276581300013
PM 20045461
DA 2025-06-11
ER

PT J
AU Bo, S
   Gambino, R
   Gentile, L
   Pagano, G
   Rosato, R
   Saracco, GM
   Cassader, M
   Durazzo, M
   Cavallo-Perin, P
AF Bo, Simona
   Gambino, Roberto
   Gentile, Luigi
   Pagano, Gianfranco
   Rosato, Rosalba
   Saracco, Giorgio Maria
   Cassader, Maurizio
   Durazzo, Marilena
   Cavallo-Perin, Paolo
TI High-normal blood pressure is associated with a cluster of
   cardiovascular and metabolic risk factors: a population-based study
SO JOURNAL OF HYPERTENSION
LA English
DT Article
DE adipokines; cardiovascular risk factors; endothelial dysfunction; high
   normal blood pressure; metabolic syndrome
ID HOMEOSTASIS MODEL ASSESSMENT; C-REACTIVE PROTEIN; ALANINE
   AMINOTRANSFERASE; ENDOTHELIAL FUNCTION; INSULIN-RESISTANCE;
   HYPERTENSION; DISEASE; DYSFUNCTION; PROGRESSION; PREVALENCE
AB Objective A Few population-based studies have shown that high-normal blood pressure clusters with other cardiovascular risk factors. Increased inflammation, endothelial dysfunction, oxidative stress, and reduced adiponectin values have sporadically been reported in these patients.
   Methods We cross-sectionally compared blood pressure categories with cardiovascular risk factors in an adult population-based cohort (n = 1658) and evaluated the relationships between C-reactive-protein, nitrotyrosine, total antioxidant status, E-selectin, vascular adhesion molecule-1, intercellular adhesion molecule-1, resistin, adiponectin values and blood pressure categories in a subgroup of healthy lean individuals from this cohort (n = 107) in order to exclude the impact of obesity/insulin resistance on these variables.
   Results Glucose, triglyceride, low-density lipoprotein-cholesterol, alanine aminotranferase, gamma-glutamyl transferase values, and diabetes and metabolic syndrome prevalence were significantly higher in high-normal compared with the optimal blood pressure category. In the healthy subgroup, adiponectin (beta = -4315.3; 95% confidence interval -5916.4 -2654.2), total antioxidant status (-0.15; -0.3 -0.04) were significantly lower, and nitrotyrosine (1.2; 0.3 2.1), E-selectin (11.7; 1.8 21.6), vascular adhesion molecule-1 (0.3; 0.1 0.5), and intercellular adhesion molecule-1 ( 0.3; 0.1 0.5) were higher in high-normal compared with the optimal blood pressure category, at multiple regression analyses.
   Conclusions Individuals with high-normal blood pressure had a higher prevalence of cardiovascular and metabolic risk factors than those with optimal, and, even if healthy, they showed reduced adiponectin values, early signs of endothelial dysfunction, and oxidative stress. Further research is needed to determine whether they will benefit from blood pressure reduction. J Hypertens 27: 102-108 (C) 2009 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
C1 [Bo, Simona; Gambino, Roberto; Pagano, Gianfranco; Cassader, Maurizio; Durazzo, Marilena; Cavallo-Perin, Paolo] Univ Turin, Dept Internal Med, I-10126 Turin, Italy.
   [Rosato, Rosalba] Univ Turin, Canc Epidemiol Unit, I-10126 Turin, Italy.
   [Saracco, Giorgio Maria] Univ Turin, Dept Gastroenterol, I-10126 Turin, Italy.
   [Gentile, Luigi] Hosp Asti, Diabet Clin, Asti, Italy.
C3 University of Turin; University of Turin; University of Turin
RP Bo, S (corresponding author), Univ Turin, Dept Internal Med, I-10126 Turin, Italy.
EM sbo@molinette.piemonte.it
RI Saracco, Guido/C-9834-2013; rosato, rosalba/ACO-0658-2022; GAMBINO,
   Roberto/AAC-7517-2022; Bo, Simona/AAC-1110-2019
OI Saracco, Giorgio Maria/0000-0001-5310-4143; ROSATO,
   Rosalba/0000-0002-4921-374X; Bo, Simona/0000-0001-6862-8628; DURAZZO,
   Marilena/0000-0003-2450-5911
CR [Anonymous], 2005, IDF CONS WORLDW DEF
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NR 31
TC 24
Z9 24
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0263-6352
EI 1473-5598
J9 J HYPERTENS
JI J. Hypertens.
PD JAN
PY 2009
VL 27
IS 1
BP 102
EP 108
DI 10.1097/HJH.0b013e328317a7bb
PG 7
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 379TO
UT WOS:000261419300018
PM 19145777
DA 2025-06-11
ER

PT J
AU de Sousa, MF
   Ling, JY
   Asquieri, E
   Whisner, C
   Sweazea, KL
AF de Sousa, Milena Figueiredo
   Ling, Jingyu
   Asquieri, Eduardo
   Whisner, Corrie
   Sweazea, Karen L.
TI Examination of a novel dietary fiber formulation on morphology and
   nutritional physiology of young male Sprague-Dawley rats fed a high fat
   diet
SO PEERJ
LA English
DT Article
DE Fiber; High fat diet; Metabolic syndrome; Diabetes mellitus; Rodent
ID GRAPE SEED FLOUR; OXIDATIVE STRESS; BODY-COMPOSITION; WHEAT BRAN;
   SUPPLEMENTATION; PROFILE; BIOMARKERS; PSYLLIUM; FLAXSEED; OBESITY
AB Western diets are a public health concern as excess intake of simple sugars and fatty foods, and consequently low consumption of fruits and vegetables, can contribute to obesity and other chronic diseases such as diabetes mellitus, metabolic syndrome, cardiovascular diseases, and cancer. Due to the high prevalence of diseases related to Western diets, the objective of this study was to evaluate whether the inclusion of a novel fiber-rich complex could prevent high fat diet-induced weight gain, adiposity, hyperglycemia, dyslipidemia, and oxidative stress in young male Sprague-Dawley rats, Rattus norvegicus. The novel fiber complex contained a blend of bioactive ingredients: 27% flaxseed, 15.9% wheat bran, 14.8% wheat germ, 10% psyllium, 13.1% brewer's yeast, and 19.2% grapeseed flour. The study included 24 6-week-old rats divided into three groups that were fed either a control diet (C; standard rodent maintenance diet) containing fiber (3.8%g diet); high-fat diet (H) containing Solka Floc cellulose fiber (6.46%g diet); or high-fat diet in which 5% of the diet was replaced with the novel fiber complex (HF) (total fiber: 5%g fiber complex + 6.14%g Solka Floc). Rats in all diet groups gained significant weight during the 6-week feeding period (p < 0.001) consistent with normal growth. Whereas no differences were observed for blood lipids or beta-hydroxybutyrate, consumption of the H diet significantly increased adiposity (p < 0.001), liver triglycerides (p < 0.001), and fasting whole blood glucose concentrations (p < 0.001) in comparison to the C diet. These effects of high fat consumption were not prevented by the inclusion of the novel fiber complex in this experimental design.
C1 [de Sousa, Milena Figueiredo; Ling, Jingyu; Whisner, Corrie; Sweazea, Karen L.] Arizona State Univ, Coll Hlth Solut, Phoenix, AZ 85004 USA.
   [de Sousa, Milena Figueiredo; Asquieri, Eduardo] Univ Fed Goias, Sch Pharm, Goiania, Brazil.
   [Sweazea, Karen L.] Arizona State Univ, Sch Life Sci, Tempe, AZ 85287 USA.
C3 Arizona State University; Arizona State University-Downtown Phoenix;
   Universidade Federal de Goias; Arizona State University; Arizona State
   University-Tempe
RP de Sousa, MF; Sweazea, KL (corresponding author), Arizona State Univ, Coll Hlth Solut, Phoenix, AZ 85004 USA.; de Sousa, MF (corresponding author), Univ Fed Goias, Sch Pharm, Goiania, Brazil.; Sweazea, KL (corresponding author), Arizona State Univ, Sch Life Sci, Tempe, AZ 85287 USA.
EM milenafnut@gmail.com; Karen.Sweazea@asu.edu
RI Whisner, Corrie/M-7652-2019; Sweazea, Karen/AAT-4151-2020
OI Sweazea, Karen/0000-0003-0345-4086; Whisner, Corrie/0000-0003-3888-6348;
   Ramirez Asquieri, Eduardo/0000-0003-3312-8003
FU Arizona State University College of Health Solutions; Coordination for
   the Improvement of Higher Education Personnel (CAPES); Graduate and
   Professional Student Association at Arizona State University
FX This research was funded by the Arizona State University College of
   Health Solutions. Coordination for the Improvement of Higher Education
   Personnel (CAPES) provided funding to researcher Milena Figueiredo de
   Sousa during her exchange at Arizona State University (Arizona-USA).
   Funds were additionally provided by the Graduate and Professional
   Student Association at Arizona State University (Jingyu Ling). The
   funders had no role in study design, data collection and analysis,
   decision to publish, or preparation of the manuscript.
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TC 0
Z9 0
U1 1
U2 1
PU PEERJ INC
PI LONDON
PA 341-345 OLD ST, THIRD FLR, LONDON, EC1V 9LL, ENGLAND
SN 2167-8359
J9 PEERJ
JI PeerJ
PD FEB 20
PY 2025
VL 13
AR e19029
DI 10.7717/peerj.19029
PG 20
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 1NT9G
UT WOS:001469406400001
PM 39989745
OA gold
DA 2025-06-11
ER

PT J
AU Singh, S
   Mishra, A
   Alka
AF Singh, Shiva
   Mishra, Anuradha
   Alka
TI Unlocking the therapeutic potential of Geraniol: an alternative
   perspective for metabolic disease management
SO INFLAMMOPHARMACOLOGY
LA English
DT Review
DE Metabolic disorder; Geraniol; Insulin resistance; Obesity; Cancer
ID ESSENTIAL OIL CONTENT; CHEMICAL-COMPOSITION; OXIDATIVE STRESS;
   INSULIN-RESISTANCE; COMPLICATIONS; MODULATION; IMPROVES; PLANTS; YIELD
AB Ethnopharmacological relevanceNatural substance geraniol has anti-inflammatory and antioxidant qualities. It may be used to treat metabolic diseases such as diabetes, obesity, and cardiovascular illnesses. Innovations in nanoformulations enhance geraniol's absorption, stability, and targeted distribution, augmenting its therapeutic effectiveness and mitigating side effects, despite the limits of traditional treatment.Aim of the reviewThe therapeutic potential of geraniol in the management of metabolic disorders such as diabetes, obesity, neuroinflammation, and cardiovascular disease is examined in this review. It highlights the anti-inflammatory, antioxidant, and lipid-lowering qualities of geraniol as well as the potential for nanoformulations to increase bioavailability and therapeutic efficacy.Materials and methodsA collection of pertinent research articles about the potential of geraniol in metabolic illnesses, including obesity, type 2 diabetes, as well as cardiovascular diseases, was compiled from PubMed, Scopus, and Google Scholar. Terms such as "metabolic syndrome," "antioxidant," "anti-inflammatory," "geraniol," and "nanoformulations" were employed. Google Patents were also examined in order to offer insights into current and upcoming research.ResultsThe potential of geraniol to treat metabolic disorders, including obesity, diabetes, hyperlipidemia, and cardiovascular illnesses, is thoroughly reviewed in this article. Recent research has demonstrated the lipid-lowering, antioxidant, and anti-inflammatory properties of geraniol as well as its ability to improve endothelial function and reduce oxidative stress in preclinical animals. The paper delves into the various nanoformulations, including liposomes, nanoparticles, and nanoemulsions, which enhance geraniol's therapeutic efficacy and bioavailability, making it a viable option for managing metabolic syndrome.ConclusionThe antioxidant, anti-inflammatory, and lipid-lowering qualities of geraniol make it a promising treatment for metabolic diseases. Its bioavailability along with therapeutic efficacy are increased by nanoformulations, which makes it a compelling option for the treatment of conditions such as neuroinflammation, diabetes, and obesity.
C1 [Singh, Shiva; Mishra, Anuradha; Alka] Amity Univ Uttar Pradesh, Amity Inst Pharm, Sect 125, Noida 201313, Uttar Pradesh, India.
C3 Amity University Noida
RP Mishra, A (corresponding author), Amity Univ Uttar Pradesh, Amity Inst Pharm, Sect 125, Noida 201313, Uttar Pradesh, India.
EM misra.anuradha@gmail.com
RI Mishra, Anuradha/J-2840-2019
OI Mishra, Prof Anuradha/0000-0002-2675-3479
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NR 101
TC 1
Z9 1
U1 0
U2 1
PU SPRINGER BASEL AG
PI BASEL
PA PICASSOPLATZ 4, BASEL, 4052, SWITZERLAND
SN 0925-4692
EI 1568-5608
J9 INFLAMMOPHARMACOLOGY
JI Inflammopharmacology
PD DEC
PY 2024
VL 32
IS 6
BP 3653
EP 3668
DI 10.1007/s10787-024-01582-0
EA OCT 2024
PG 16
WC Immunology; Pharmacology & Pharmacy; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Pharmacology & Pharmacy; Toxicology
GA L7H1W
UT WOS:001342061000001
PM 39460887
DA 2025-06-11
ER

PT J
AU Castañe, H
   Jiménez-Franco, A
   Martínez-Navidad, C
   Placed-Gallego, C
   Cambra-Cortés, V
   Perta, AM
   París, M
   Castillo, DD
   Arenas, M
   Camps, J
   Joven, J
AF Castane, Helena
   Jimenez-Franco, Andrea
   Martinez-Navidad, Cristian
   Placed-Gallego, Cristina
   Cambra-Cortes, Vicente
   Perta, Adelina-Miruna
   Paris, Marta
   Castillo, Daniel del
   Arenas, Meritxell
   Camps, Jordi
   Joven, Jorge
TI Serum Arylesterase, Paraoxonase, and Lactonase Activities and
   Paraoxonase-1 Concentrations in Morbidly Obese Patients and Their
   Relationship with Non-Alcoholic Steatohepatitis
SO ANTIOXIDANTS
LA English
DT Article
DE arylesterase; lactonase; morbid obesity; non-alcoholic fatty liver
   disease; non-alcoholic steatohepatitis; obesity; paraoxonase-1
ID HIGH-DENSITY-LIPOPROTEIN; OXIDATIVE STRESS; METABOLIC SYNDROME;
   CARDIOVASCULAR-DISEASE; INSULIN-RESISTANCE; CHOLESTEROL; PON1;
   POLYMORPHISM; PLASMA; GENE
AB Paraoxonase-1 (PON1) is an antioxidant enzyme associated with high-density lipoproteins (HDL). Reduced serum PON1 activity is found in diseases marked by oxidative stress and inflammation, but its role in obesity remains unclear. This study investigated PON1 activities and concentrations in morbidly obese individuals and explored the impacts of the genetic polymorphism PON1 rs662 and non-alcoholic fatty liver disease on enzymatic properties. We recruited 1349 morbidly obese patients undergoing bariatric surgery and 823 non-obese volunteers. PON1-related variables, including arylesterase, paraoxonase, and lactonase activities and PON1 concentrations, were examined. Our results showed that morbidly obese individuals exhibited higher PON1 concentrations but lower enzymatic activities than non-obese individuals. We observed inverse associations of arylesterase and paraoxonase activities with waist circumference (rho = -0.24, p < 0.001, and rho = -0.30, p < 0.001, respectively) and body mass index (rho = -0.15, p = 0.001, and rho = -0.23, p < 0.001), as well as direct associations of arylesterase, paraoxonase, and lactonase activities with HDL cholesterol (rho = 0.11, p = 0.005, rho = 0.20, p < 0.001, and rho = 0.20, p < 0.001). No significant differences were observed regarding metabolic syndrome, type 2 diabetes mellitus, hypertension, dyslipidemia, rs662 polymorphism allele frequencies, or the diagnosis of non-alcoholic steatohepatitis. Nevertheless, correlations were found between certain PON1-related variables, steatosis, and ballooning. In conclusion, changes in PON1-related variables in morbidly obese patients are dependent on the disease itself and HDL levels. The relationships between these variables and specific liver histological changes raise intriguing questions for consideration in future studies.
C1 [Castane, Helena; Jimenez-Franco, Andrea; Martinez-Navidad, Cristian; Placed-Gallego, Cristina; Cambra-Cortes, Vicente; Perta, Adelina-Miruna; Arenas, Meritxell; Camps, Jordi; Joven, Jorge] Univ Rovira & Virgili, Hosp Univ St Joan, Inst Invest Sanitaria Pere Virgili, Unitat Recerca Biomed, Av Dr Josep Laporte 2, Reus 43204, Spain.
   [Paris, Marta; Castillo, Daniel del] Univ Rovira & Virgili, Hosp Univ St Joan, Inst Invest Sanitaria Pere Virgili, Dept Bariatr Surg, Av Dr Josep Laporte 2, Reus 43204, Spain.
   [Arenas, Meritxell] Univ Rovira & Virgili, Hosp Univ St Joan, Inst Invest Sanitaria Pere Virgili, Dept Radiat Oncol, Av Dr Josep Laporte 2, Reus 43204, Spain.
C3 Universitat Rovira i Virgili; Institut d'Investigacio Sanitaria Pere
   Virgili (IISPV); Universitat Rovira i Virgili; Institut d'Investigacio
   Sanitaria Pere Virgili (IISPV); Universitat Rovira i Virgili; Institut
   d'Investigacio Sanitaria Pere Virgili (IISPV)
RP Camps, J; Joven, J (corresponding author), Univ Rovira & Virgili, Hosp Univ St Joan, Inst Invest Sanitaria Pere Virgili, Unitat Recerca Biomed, Av Dr Josep Laporte 2, Reus 43204, Spain.
EM helena.castane@iispv.cat; andrea.jimenez@urv.cat;
   cristian.martinez@iispv.cat; crisplaced@hotmail.com;
   vicente.cambra@urv.cat; adelina.miruna@iispv.cat;
   marta.paris@salutsantjoan.cat; danieldel.castillo@urv.cat;
   meritxell.arenas@urv.cat; jorge.camps@salutsantjoan.cat;
   jorge.joven@urv.cat
RI Camps, Jordi/IVH-2701-2023; Castañé, Helena/AFO-7722-2022; Arenas,
   Meritxell/HCG-8786-2022; Joven, Jorge/B-3360-2016; Arenas Prat,
   Meritxell/F-2631-2014
OI Camps, Jordi/0000-0002-3165-3640; Joven, Jorge/0000-0003-2749-4541;
   Cambra, Vicente/0009-0002-9574-6261; Perta,
   Adelina-Miruna/0009-0002-4590-6079; PARIS SANS,
   MARTA/0000-0001-9861-5801; Jimenez Franco, Andrea/0000-0002-4251-585X;
   Arenas Prat, Meritxell/0000-0003-0815-2570
FU Instituto de Salud Carlos III, Madrid, Spain
FX No Statement Available
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NR 63
TC 5
Z9 5
U1 0
U2 3
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD DEC
PY 2023
VL 12
IS 12
AR 2038
DI 10.3390/antiox12122038
PG 16
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA DM0Y9
UT WOS:001132355100001
PM 38136158
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Vancampfort, D
   Mugisha, J
   De Hert, M
   Probst, M
   Stubbs, B
AF Vancampfort, Davy
   Mugisha, James
   De Hert, Marc
   Probst, Michel
   Stubbs, Brendon
TI Sedentary Behavior in People Living With HIV: A Systematic Review and
   Meta-Analysis
SO JOURNAL OF PHYSICAL ACTIVITY & HEALTH
LA English
DT Review
DE sitting; physical activity; chronic disease
ID MAJOR DEPRESSIVE DISORDER; PHYSICAL-ACTIVITY; METABOLIC SYNDROME;
   BIPOLAR DISORDER; ANTIRETROVIRAL THERAPY; ADULTS; RISK; EXERCISE; TIME;
   SCHIZOPHRENIA
AB Background: Sedentary behavior is independently associated with an increased risk of poor mental health, developing cardiovascular disease (CVD) and premature mortality. Despite the knowledge that CVD is one of the leading causes of non-AIDS related premature mortality in people living with HIV (PLWH), relatively little attention has been attributed to sedentary behavior in this population. The aims of this meta-analysis were to (a) establish the pooled mean time spent sedentary, (b) investigate predictors of sedentary levels, and (c) explore differences with age- and gender-matched healthy controls. Methods: Two independent authors searched major databases until August 2016. A random effects meta-analysis was performed. Results: Across 6 unique cross-sectional studies, including 9 sedentary levels, there were 523 (292 men) PLWH (age range = 37 to 58 years). PLWH spent 533 min/day (95% CI = 466 to 599) engaging in sedentary behavior. There was a trend (P = .07) for higher levels of sedentary behavior in self-report measures (551 min, 95% CI = 543 to 560, N = 4) than in objective sedentary behavior time (505 min, 95% CI = 498 to 512, N = 3). The time PLWH spend engaging in sedentary behavior is among the highest levels reported in the literature. Conclusions: Given that sedentary behavior is an independent predictor of CVD, future lifestyle interventions specifically targeting the prevention of sedentary behavior in PLWH are warranted.
C1 [Vancampfort, Davy; Probst, Michel] Univ Leuven, KU Leuven, Dept Rehabil Sci, Leuven, Belgium.
   [Vancampfort, Davy; De Hert, Marc] Univ Leuven, KU Leuven, Univ Psychiat Ctr, Leuven Kortenberg, Belgium.
   [Mugisha, James] Butabika Natl Referral & Mental Hlth Hosp, Kampala, Uganda.
   [Mugisha, James] Kyambogo Univ, Kampala, Uganda.
   [Stubbs, Brendon] South London & Maudsley NHS Fdn Trust, Physiotherapy Dept, London, England.
   [Stubbs, Brendon] Kings Coll London, Hlth Serv & Populat Res Dept, Inst Psychiat Psychol & Neurosci, London, England.
C3 KU Leuven; KU Leuven; Kyambogo University; South London & Maudsley NHS
   Trust; University of London; King's College London
RP Vancampfort, D (corresponding author), Univ Leuven, KU Leuven, Dept Rehabil Sci, Leuven, Belgium.; Vancampfort, D (corresponding author), Univ Leuven, KU Leuven, Univ Psychiat Ctr, Leuven Kortenberg, Belgium.
EM davy.vancampfort@uc-kortenberg.be
RI Vancampfort, Davy/AAD-1987-2019; De Hert, Marc/AAH-6090-2021; Probst,
   Michel/ABE-6137-2020; Stubbs, Brendon/X-1904-2018; Stubbs,
   Brendon/C-5696-2015
OI De Hert, Marc/0000-0003-4255-5920; Stubbs, Brendon/0000-0001-7387-3791;
   Mugisha, James/0000-0003-2084-8693
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NR 35
TC 25
Z9 26
U1 0
U2 16
PU HUMAN KINETICS PUBL INC
PI CHAMPAIGN
PA 1607 N MARKET ST, PO BOX 5076, CHAMPAIGN, IL 61820-2200 USA
SN 1543-3080
EI 1543-5474
J9 J PHYS ACT HEALTH
JI J. Phys. Act. Health
PD JUL
PY 2017
VL 14
IS 7
BP 571
EP 577
DI 10.1123/jpah.2016-0507
PG 7
WC Public, Environmental & Occupational Health
WE Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA EZ6MW
UT WOS:000404833000009
PM 28290767
DA 2025-06-11
ER

PT J
AU Paley, CA
   Johnson, MI
AF Paley, Carole A.
   Johnson, Mark I.
TI Physical Activity to Reduce Systemic Inflammation Associated With
   Chronic Pain and Obesity A Narrative Review
SO CLINICAL JOURNAL OF PAIN
LA English
DT Review
DE chronic pain; adiposopathy; metabolic syndrome; exercise; obesity
ID BODY-MASS INDEX; LOW-BACK-PAIN; QUALITY-OF-LIFE; CHRONIC WIDESPREAD
   PAIN; WEIGHT-LOSS; MUSCULOSKELETAL PAIN; KNEE OSTEOARTHRITIS; WAIST
   CIRCUMFERENCE; LONGITUDINAL DATA; RISK-FACTORS
AB Introduction:
   The increasing prevalence of chronic pain and obesity has significant health and cost implications for economies in the developed and developing world. Evidence suggests that there is a positive correlation between obesity and chronic pain and the link between them is thought to be systemic inflammation.
   Objectives:
   The aim of this narrative review was to explore the physiological links between chronic musculoskeletal pain and obesity and to consider the potential role of regular physical activity in providing a means of managing obesity-related chronic pain.
   Discussion:
   Systemic inflammation, mechanical overload, and autonomic dysfunction are associated with increased prevalence and severity of chronic pain in individuals with obesity. It has been proposed, therefore, that interventions that target systemic inflammation could help to reduce chronic pain in obese individuals. Reduction in abdominal fat has been shown to alleviate pain and reduce the systemic markers of inflammation that contribute to chronic pain. Interventions that include exercise prescription have been shown to reduce both abdominal fat and systemic inflammation. Furthermore, exercise is also known to reduce pain perception and improve mental health and quality of life that also improves pain outcomes. However, adherence to formal exercise prescription is poor and therefore exercise programmes should be tailored to the interests, needs, and abilities of individuals to reduce attrition.
C1 [Paley, Carole A.] Airedale NHS Fdn Trust, Skipton Rd, Keighley BD20 6TD, W Yorkshire, England.
   [Paley, Carole A.; Johnson, Mark I.] Leeds Beckett Univ, Fac Hlth & Social Sci, Leeds, W Yorkshire, England.
   [Paley, Carole A.; Johnson, Mark I.] Leeds Pallium Res Grp, Leeds, W Yorkshire, England.
C3 Leeds Beckett University; University of Leeds
RP Paley, CA (corresponding author), Airedale NHS Fdn Trust, Skipton Rd, Keighley BD20 6TD, W Yorkshire, England.
EM carole.paley@anhst.nhs.uk
RI Paley, Carole/AAM-2469-2020; Paley, Carole Anne/HMV-0264-2023
OI Paley, Carole Anne/0000-0002-6335-2666
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NR 79
TC 52
Z9 58
U1 0
U2 30
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0749-8047
EI 1536-5409
J9 CLIN J PAIN
JI Clin. J. Pain
PD APR
PY 2016
VL 32
IS 4
BP 365
EP 370
DI 10.1097/AJP.0000000000000258
PG 6
WC Anesthesiology; Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Anesthesiology; Neurosciences & Neurology
GA DI9MO
UT WOS:000373827200011
PM 25988939
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Branyan, KW
   Devallance, ER
   Lemaster, KA
   Skinner, RC
   Bryner, RW
   Olfert, IM
   Kelley, EE
   Frisbee, JC
   Chantler, PD
AF Branyan, Kayla W.
   Devallance, Evan R.
   Lemaster, Kent A.
   Skinner, R. Christopher
   Bryner, Randy W.
   Olfert, I. Mark
   Kelley, Eric E.
   Frisbee, Jefferson C.
   Chantler, Paul D.
TI Role of Chronic Stress and Exercise on Microvascular Function in
   Metabolic Syndrome
SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
LA English
DT Article
DE OBESITY; UCMS; SKELETAL MUSCLE ARTERIOLE; ENDOTHELIAL DYSFUNCTION
ID PERIPHERAL ARTERIAL-DISEASE; CARDIOVASCULAR-DISEASE; VASCULAR
   DYSFUNCTION; DEPRESSIVE SYMPTOMS; ANIMAL-MODELS; UNITED-STATES;
   ANTIOXIDANT; RAREFACTION; PREVALENCE; REACTIVITY
AB Purpose The present study examined the effect of unpredictable chronic mild stress (UCMS) on peripheral microvessel function in healthy and metabolic syndrome (MetS) rodents and whether exercise training could prevent the vascular dysfunction associated with UCMS.
   Methods Lean and obese (model of MetS) Zucker rats (LZR and OZR) were exposed to 8 wk of UCMS, exercise (Ex), UCMS + Ex, or control conditions. At the end of the intervention, gracilis arterioles (GA) were isolated and hung in a pressurized myobath to assess endothelium-dependent (EDD) and endothelium-independent (EID) dilation. Levels of nitric oxide (NO) and reactive oxygen species (ROS) were measured through 4-amino-5-methylamino-2,7-difluorofluorescein diacetate and dihydroethidium staining, respectively.
   Results Compared with LZR controls, EDD and EID were lower (P = 0.0001) in LZR-UCMS. The OZR-Ex group had a higher EDD (P = 0.0001) and EID (P = 0.003) compared with OZR controls, whereas only a difference in EDD (P = 0.01) was noted between the LZR-control and LZR-Ex groups. Importantly, EDD and EID were higher in the LZR (P = 0.0001; P = 0.02) and OZR (P = 0.0001; P = 0.02) UCMS + Ex groups compared with UCMS alone. Lower NO bioavailability and higher ROS were noted in the LZR-UCMS group (P = 0.0001), but not OZR-UCMS, compared with controls. The Ex and UCMS-Ex groups had higher NO bioavailability (P = 0.0001) compared with the control and UCMS groups, but ROS levels remained high.
   Conclusions The comorbidity between UCMS and MetS does not exacerbate the effects of one another on GA EDD responses, but does lead to the development of other vasculopathy adaptations, which can be partially explained by alterations in NO and ROS production. Importantly, exercise training alleviates most of the negative effects of UCMS on GA function.
C1 [Branyan, Kayla W.; Devallance, Evan R.; Skinner, R. Christopher; Bryner, Randy W.; Olfert, I. Mark; Chantler, Paul D.] West Virginia Univ, Sch Med, Div Exercise Physiol, Morgantown, WV USA.
   [Lemaster, Kent A.; Frisbee, Jefferson C.] Univ Western Ontario, Schulich Sch Med & Dent, Dept Med Biophys, Transdisciplinary Program Vasc Hlth, London, ON, Canada.
   [Kelley, Eric E.] West Virginia Univ, Dept Physiol & Pharmacol, Morgantown, WV USA.
C3 West Virginia University; Western University (University of Western
   Ontario); West Virginia University
RP Chantler, PD (corresponding author), 1 Med Ctr Dr,POB 9227, Morgantown, WV 26506 USA.
EM pchantler@hsc.wvu.edu
OI Branyan, Kayla/0000-0003-1038-8080; Frisbee,
   Jefferson/0000-0003-2751-0599
FU American Heart Association [IRG 14330015]; predoctoral fellowship AHA
   [14PRE 20380386]; National Institute of General Medical Sciences of the
   National Institutes of Health [U54GM104942, 5P20GM109098]; NIH
   [3P01AG043376-02S1]
FX This work was supported by the American Heart Association grants IRG
   14330015 and predoctoral fellowship AHA 14PRE 20380386, and the National
   Institute of General Medical Sciences of the National Institutes of
   Health under award numbers U54GM104942, 5P20GM109098, and NIH
   3P01AG043376-02S1.
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NR 51
TC 13
Z9 16
U1 0
U2 7
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0195-9131
EI 1530-0315
J9 MED SCI SPORT EXER
JI Med. Sci. Sports Exerc.
PD MAY
PY 2018
VL 50
IS 5
BP 957
EP 966
DI 10.1249/MSS.0000000000001531
PG 10
WC Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Sport Sciences
GA GE4IW
UT WOS:000431180100009
PM 29271845
OA Green Accepted, Green Submitted
DA 2025-06-11
ER

PT J
AU Tiwari, R
   Verma, S
   Verma, N
   Verma, D
   Narayan, J
AF Tiwari, Ritu
   Verma, Shivam
   Verma, Narsingh
   Verma, Dileep
   Narayan, Jagdish
TI Correlation of serum uric acid levels with certain anthropometric
   parameters in prediabetic and drug-naive diabetic subjects
SO ANNALS OF AFRICAN MEDICINE
LA English
DT Article
DE Anthropometric; metabolic syndrome; microalbuminuria; serum uric acid
ID ADIPOSE-TISSUE; INSULIN-RESISTANCE; METABOLIC SYNDROME; OXIDATIVE
   STRESS; TNF-ALPHA; ADIPOCYTE SIZE; ANTIOXIDANT; EXPRESSION; OBESITY;
   ONSET
AB Introduction: Uric acid is produced during the metabolism of nucleotide and adenosine triphosphate and contains the final product of human purine metabolism. It acts both as an antioxidant and pro-inflammatory marker and has a positive association with visceral fat in overweight subjects. The aim of the present study is to find an association of uric acid level with certain anthropometric parameters in subjects having type 2 diabetes. Materials and Methods: The study included 124 urban drug-naive diabetic Indian subjects above 18 years of age from the general population of the city of North India. Uric acid concentrations were estimated by the uricase method. Fasting plasma glucose (FPG) concentrations were estimated by the glucose oxidase-peroxidase method. Anthropometric measurements and information on lifestyle factors and disease history were collected through in-person meeting. Results: All participants of the study subjects had a body mass index (BMI) of more than 23.5. BMI, waist-to-hip ratio (WHR), waist-to-height ratio, waist circumference, neck circumference, weight, age, sagittal abdominal diameter (SAD), skinfold thickness, and body roundness index were positively correlated with the serum uric acid level. The correlation of weight, BMI, SAD, and WHR was statistically significant. Conclusion: We found that serum uric acid level increases as body fat content increases. Statistical data show remarkable results for a significant correlation of uric acid level with BMI, WHR, SAD, and FPG. Hypertrophy occurs as a result of inflammatory processes and oxidative stress when the supply of energy starts to exceed the storage capacity of adipocytes, as a result, adipokines such as interleukin (IL)-1, IL-6, and tumor-necrosis factor-alpha are released more frequently which lead to low-grade chronic inflammation. Uric acid levels are much lean toward visceral obesity than overall body fat content.
C1 [Tiwari, Ritu; Verma, Shivam; Verma, Narsingh; Verma, Dileep; Narayan, Jagdish] King George Med Univ, Dept Physiol, Lucknow, Uttar Pradesh, India.
C3 King George's Medical University
RP Verma, S (corresponding author), King George Med Univ, Dept Physiol, Lucknow, Uttar Pradesh, India.
EM shivam9236@gmail.com
RI verma, nipun/GLN-5512-2022
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NR 45
TC 1
Z9 1
U1 0
U2 0
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, Maharashtra, INDIA
SN 1596-3519
EI 0975-5764
J9 ANN AFR MED
JI Ann. Afr. Med.
PD JAN-MAR
PY 2024
VL 23
IS 1
BP 13
EP 18
DI 10.4103/aam.aam_40_22
PG 6
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA KN7Q7
UT WOS:001180714500015
PM 38358165
DA 2025-06-11
ER

PT J
AU Ruiz-Núñez, B
   Pruimboom, L
   Dijck-Brouwer, DAJ
   Muskiet, FAJ
AF Ruiz-Nunez, Begona
   Pruimboom, Leo
   Dijck-Brouwer, D. A. Janneke
   Muskiet, Frits A. J.
TI Lifestyle and nutritional imbalances associated with Western diseases:
   causes and consequences of chronic systemic low-grade inflammation in an
   evolutionary context
SO JOURNAL OF NUTRITIONAL BIOCHEMISTRY
LA English
DT Review
DE Chronic systemic low grade inflammation; Evolution; Brain;
   Encephalization quotient; Immune system; Diet; Fatty acids; Fish oil;
   Fruits; Vegetables; Antioxidant network; Metabolic syndrome; Glucose;
   Homeostasis; Insulin resistance; Cholesterol; Lifestyle; Antioxidants;
   Resoleomics; Pro-inflammatory nutrients; Anti-inflammatory nutrients
ID POLYUNSATURATED FATTY-ACIDS; CORONARY-HEART-DISEASE; C-REACTIVE PROTEIN;
   RANDOMIZED CONTROLLED-TRIAL; ALPHA-LINOLENIC ACID; INSULIN-RESISTANCE;
   ARACHIDONIC-ACID; OXIDATIVE STRESS; CARDIOVASCULAR-DISEASE; METABOLIC
   SYNDROME
AB In this review, we focus on lifestyle changes, especially dietary habits, that are at the basis of chronic systemic low grade inflammation, insulin resistance and Western diseases. Our sensitivity to develop insulin resistance traces back to our rapid brain growth in the past 2.5 million years. An inflammatory reaction jeopardizes the high glucose needs of our brain, causing various adaptations, including insulin resistance, functional reallocation of energy-rich nutrients and changing serum lipoprotein composition. The latter aims at redistribution of lipids, modulation of the immune reaction, and active inhibition of reverse cholesterol transport for damage repair. With the advent of the agricultural and industrial revolutions, we have introduced numerous false inflammatory triggers in our lifestyle, driving us to a state of chronic systemic low grade inflammation that eventually leads to typically Western diseases via an evolutionary conserved interaction between our immune system and metabolism. The underlying triggers are an abnormal dietary composition and microbial flora, insufficient physical activity and sleep, chronic stress and environmental pollution. The disturbance of our inflammatory/anti-inflammatory balance is illustrated by dietary fatty acids and antioxidants. The current decrease in years without chronic disease is rather due to "nurture" than "nature," since less than 5% of the typically Western diseases are primary attributable to genetic factors. Resolution of the conflict between environment and our ancient genome might be the only effective manner for "healthy aging," and to achieve this we might have to return to the lifestyle of the Paleolithic era as translated to the 21st century culture. (C) 2013 Elsevier Inc. All rights reserved.
C1 [Ruiz-Nunez, Begona; Dijck-Brouwer, D. A. Janneke; Muskiet, Frits A. J.] Univ Groningen, Univ Med Ctr Groningen, NL-9700 RB Groningen, Netherlands.
   [Pruimboom, Leo] Univ Gerona, Fac Sci, Girona, Spain.
   [Pruimboom, Leo] Graz Univ, Unit Life, A-8010 Graz, Austria.
C3 University of Groningen; University of Graz
RP Muskiet, FAJ (corresponding author), Univ Groningen, Univ Med Ctr Groningen, Internal Zip Code EA61,Hanzepl,1,POB 30-001, NL-9700 RB Groningen, Netherlands.
EM f.a.j.muskiet@umcg.nl
OI Pruimboom, Leo/0000-0003-2955-4675; Dijck-Brouwer,
   Janneke/0000-0003-1346-8254
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NR 332
TC 173
Z9 195
U1 1
U2 109
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0955-2863
EI 1873-4847
J9 J NUTR BIOCHEM
JI J. Nutr. Biochem.
PD JUL
PY 2013
VL 24
IS 7
BP 1183
EP 1201
DI 10.1016/j.jnutbio.2013.02.009
PG 19
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA 177YZ
UT WOS:000321412600001
PM 23657158
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU BarChana, M
   Levav, I
   Lipshitz, I
   Pugachova, I
   Kohn, R
   Weizman, A
   Grinshpoon, A
AF BarChana, Micha
   Levav, Itzhak
   Lipshitz, Irena
   Pugachova, Inna
   Kohn, Robert
   Weizman, Abraham
   Grinshpoon, Alexander
TI Enhanced cancer risk among patients with bipolar disorder
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE bipolar disorder; cancer; epidemiology; Israel
ID PSYCHIATRIC-DISORDERS; DEPRESSIVE DISORDER; METABOLIC SYNDROME; EXCESS
   MORTALITY; MENTAL-HEALTH; SCHIZOPHRENIA; POPULATION; LITHIUM; SAMPLE;
   PROLIFERATION
AB Background: In contrast to numerous epidemiological studies that explored the risk for cancer among persons with schizophrenic psychoses, analogous studies conducted on people with bipolar disorder are rarer, despite some commonalities in biological, treatment-related variables and unhealthy lifestyles. This study investigates the risk for cancer among psychiatric inpatients diagnosed with bipolar disorder.
   Methods: Linkage analysis was conducted based on the psychiatric and the cancer national databases. Standardized incidence ratios (SIR) for both aggregated sites and for breast cancer were calculated by comparing the incidence rates among hospitalized patients with bipolar disorder with the incidence rates in the Jewish-Israeli general population.
   Results: An enhanced cancer risk was found for bipolar disorder in both genders: men, SIR 1.59 (95% CI 1.01-2.17); women, SIR 1.75 (95% CI 1.31-2.18). The risk for breast cancer was higher, but not significantly, than in the general female population, SIR 1.70 (95% CT 0.99-2.41). Limitations: Our sample was derived from psychiatric inpatients, thus it is likely that the bipolar disorder cases had greater severity. Putative factors such as diet, smoking and medications were not investigated.
   Conclusions: Our study showed an enhanced risk for cancer among patients with bipolar disorder. Clinicians might note this risk for timely diagnosis and treatment. (C) 2007 Elsevier B.V. All rights reserved.
C1 [BarChana, Micha; Lipshitz, Irena] Minist Hlth, Canc Registry, IL-91010 Jerusalem, Israel.
   [Levav, Itzhak] Minist Hlth, Mental Hlth Serv, IL-91010 Jerusalem, Israel.
   [Kohn, Robert] Brown Univ, Dept Psychiat & Human Behav, Providence, RI 02912 USA.
   [Weizman, Abraham] Geha Mental Hlth Ctr, Petah Tiqwa, Israel.
   [Weizman, Abraham] Felsenstein Med Res Ctr, Petah Tiqwa, Israel.
   [Weizman, Abraham] Tel Aviv Univ, Sackler Fac Med, Tel Aviv, Israel.
   [Grinshpoon, Alexander] Tirat Hicarmel Mental Hlth Ctr, Tira, Israel.
C3 Ministry of Health - Israel; Ministry of Health - Israel; Brown
   University; Tel Aviv University; Tel Aviv University; Tel Aviv
   University; Sackler Faculty of Medicine
RP Levav, I (corresponding author), Minist Hlth, Canc Registry, 2 Ben Tabai St, IL-91010 Jerusalem, Israel.
EM Itzhak.Levav@moh.health.gov.il
RI Weizman, Abraham/AAK-6450-2020
OI Weizman, Abraham/0000-0002-9765-8938
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NR 39
TC 47
Z9 49
U1 0
U2 12
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0165-0327
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD MAY
PY 2008
VL 108
IS 1-2
BP 43
EP 48
DI 10.1016/j.jad.2007.09.003
PG 6
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA 295AB
UT WOS:000255446300005
PM 17904227
DA 2025-06-11
ER

PT J
AU Blomqvist, M
   Sandgren, A
   Carlsson, IM
   Jormfeldt, H
AF Blomqvist, Marjut
   Sandgren, Anna
   Carlsson, Ing-Marie
   Jormfeldt, Henrika
TI Enabling healthy living: Experiences of people with severe mental
   illness in psychiatric outpatient services
SO INTERNATIONAL JOURNAL OF MENTAL HEALTH NURSING
LA English
DT Article
DE healthy living; mental health nursing; patient's experiences;
   qualitative content analysis; severe mental illness
ID PHYSICAL HEALTH; BARRIERS; SCHIZOPHRENIA; NURSES; CARE; PERCEPTIONS;
   MANAGEMENT; PROMOTION; MORTALITY; LITERACY
AB It is well known that people with severe mental illness have a reduced life expectancy and a greater risk of being affected by preventable physical illnesses such as metabolic syndrome, cardiovascular disease and type 2 diabetes. There are still, however, only a few published studies focusing on what enables healthy living for this group. This study thus aimed to describe what enables healthy living among people with severe mental illness in psychiatric outpatient services. The data were collected in qualitative interviews (n=16) and content analysis was used to analyze the data. The interviews resulted in an overall theme Being regarded as a whole human being by self and others, which showed the multidimensional nature of health and the issues that enable healthy living among people with severe mental illness. Three categories emerged: (i) everyday structure (ii), motivating life events and (iii) support from significant others. The results indicate that a person with severe mental illness needs to be encountered as a whole person if healthy living is to be enabled. Attaining healthy living requires collaboration between the providers of care, help and support. Health care organizations need to work together to develop and provide interventions to enable healthy living and to reduce poor physical health among people with severe mental illness.
C1 [Blomqvist, Marjut; Carlsson, Ing-Marie; Jormfeldt, Henrika] Halmstad Univ, Sch Hlth & Welf, Box 823, S-30118 Halmstad, Sweden.
   [Sandgren, Anna] Linneaus Univ, Dept Hlth & Caring Sci, Vaxjo, Sweden.
C3 Halmstad University; Linnaeus University
RP Blomqvist, M (corresponding author), Halmstad Univ, Sch Hlth & Welf, Box 823, S-30118 Halmstad, Sweden.
EM Marjut.Blomqvist@hh.se
RI Carlsson, Ing-Marie/W-3946-2019
OI Blomqvist, Marjut/0000-0002-7596-5021
FU regional Council for Medical Health Care Research, County of Halland,
   Sweden; regional Council for Medical Health Care Research, County of
   Kronoberg, Sweden
FX The authors are most grateful to the participants for taking part in the
   study. The study was supported by grants from the regional Council for
   Medical Health Care Research, County of Halland, Sweden and the regional
   Council for Medical Health Care Research, County of Kronoberg, Sweden.
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NR 43
TC 27
Z9 27
U1 0
U2 18
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1445-8330
EI 1447-0349
J9 INT J MENT HEALTH NU
JI Int. J. Ment. Health Nurs.
PD FEB
PY 2018
VL 27
IS 1
BP 236
EP 246
DI 10.1111/inm.12313
PG 11
WC Nursing; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Psychiatry
GA FS3XF
UT WOS:000419717100023
PM 28160392
DA 2025-06-11
ER

PT J
AU Sun, J
   Wang, S
   Zhang, JQ
   Li, W
AF Sun, Jing
   Wang, Sheng
   Zhang, Jun-Quan
   Li, Wei
TI Assessing the cumulative effects of stress: The association between job
   stress and allostatic load in a large sample of Chinese employees
SO WORK AND STRESS
LA English
DT Article
DE allostatic load; physiology; risk factors; biomarkers; health outcomes;
   job strain; type A personality; work-related stress; China
ID CARDIOVASCULAR-DISEASE; PHYSIOLOGICAL DYSREGULATION; HEALTH DISPARITIES;
   METABOLIC SYNDROME; DECISION LATITUDE; JAPANESE WORKERS; WHITEHALL-II;
   STRAIN; RISK; MEN
AB Job stress can lead to various system dysfunctions, but until now no reliable biomarkers for its assessment have been identified. Allostatic load (AL) is an index that enables the cumulative effect on the body of chronic stress to be assessed, and is derived from a set of relevant biological measures. In this study, a 13-parameter index (building on the original 10-item index) was used to examine the relationship between job strain and AL. Participants were 1219 healthy Chinese employees. job strain was measured using the Job Content Questionnaire, and AL was assessed by various possible stress responses, including blood pressure, cholesterol, indicators of glucose metabolism, and hormone and inflammation markers. AL in the high job strain group differed sharply from that in the low job strain group. The AL score was positively associated with age and educational level. Several individual parameters also differed between the two groups. Men scored significantly higher on AL and cardiovascular and metabolic health outcomes, whereas for women the associations appeared in the biological indicators. Analyses indicated that decision latitude (DL) and job demands were significantly related to AL. job demands correlated significantly with the primary biological indicators and DL with the secondary health outcomes. In conclusion, this study provides evidence of the value of measuring allostatic load in assessing the chronic effects of job stress.
C1 [Sun, Jing; Wang, Sheng; Li, Wei] Peking Univ, Hlth Sci Ctr, Sch Publ Hlth, Dept Occupat & Environm Hlth, Beijing 100083, Peoples R China.
   [Zhang, Jun-Quan] Ctr PetroChina, Occupat Hlth Serv, Langfang, He Bei Province, Peoples R China.
C3 Peking University
RP Wang, S (corresponding author), Peking Univ, Hlth Sci Ctr, Sch Publ Hlth, Dept Occupat & Environm Hlth, Beijing 100083, Peoples R China.
EM shengw@bjmu.edu.cn
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NR 53
TC 58
Z9 78
U1 2
U2 70
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 0267-8373
EI 1464-5335
J9 WORK STRESS
JI Work Stress
PD OCT-DEC
PY 2007
VL 21
IS 4
BP 333
EP 347
DI 10.1080/02678370701742748
PG 15
WC Psychology, Applied
WE Social Science Citation Index (SSCI)
SC Psychology
GA 249RV
UT WOS:000252248300003
DA 2025-06-11
ER

PT J
AU Schroeder, M
   Jakovcevski, M
   Polacheck, T
   Drori, Y
   Ben-Dor, S
   Röh, S
   Chen, A
AF Schroeder, Mariana
   Jakovcevski, Mira
   Polacheck, Tamar
   Drori, Yonat
   Ben-Dor, Shifra
   Roeh, Simone
   Chen, Alon
TI Sex dependent impact of gestational stress on predisposition to eating
   disorders and metabolic disease
SO MOLECULAR METABOLISM
LA English
DT Article
DE Activity based anorexia; Binge eating; Obesity; Metabolic syndrome;
   Early life programming; Stress
ID ACTIVITY-BASED ANOREXIA; PRENATAL MATERNAL STRESS; FAT-SUCROSE DIET;
   PERINATAL FACTORS; FOOD-RESTRICTION; CHILDHOOD ABUSE; GENE-EXPRESSION;
   NEUROMEDIN S; RECEPTOR; OBESITY
AB Objective: Vulnerability to eating disorders (EDs) is broadly assumed to be associated with early life stress. However, a careful examination of the literature shows that susceptibility to EDs may depend on the type, severity and timing of the stressor and the sex of the individual. We aimed at exploring the link between chronic prenatal stress and predisposition to EDs and metabolic disease.
   Methods: We used a chronic variable stress protocol during gestation to explore the metabolic response of male and female offspring to food restriction (FR), activity-based anorexia (ABA), binge eating (BE) and exposure to high fat (HF) diet.
   Results: Contrary to controls, prenatally stressed (PNS) female offspring showed resistance to ABA and BE and displayed a lower metabolic rate leading to hyperadiposity and obesity on HF diet. Male PNS offspring showed healthy responses to FR and ABA, increased propensity to binge and improved coping with HF compared to controls. We found that long-lasting abnormal responses to metabolic challenge are linked to fetal programming and adult hypothalamic dysregulation in PNS females, resulting from sexually dimorphic adaptations in placental methylation and gene expression.
   Conclusions: Our results show that maternal stress may have variable and even opposing effects on ED risk, depending on the ED and the sex of the offspring. (C) 2018 The Authors. Published by Elsevier GmbH.
C1 [Schroeder, Mariana; Polacheck, Tamar; Drori, Yonat; Chen, Alon] Weizmann Inst Sci, Dept Neurobiol, IL-76100 Rehovot, Israel.
   [Schroeder, Mariana; Jakovcevski, Mira; Chen, Alon] Max Planck Inst Psychiat, Dept Stress Neurobiol & Neurogenet, D-80804 Munich, Germany.
   [Ben-Dor, Shifra] Weizmann Inst Sci, Biol Serv, Bioinformat & Biol Comp Unit, IL-76100 Rehovot, Israel.
   [Roeh, Simone] Max Planck Inst Psychiat, Dept Translat Res Psychiat, D-80804 Munich, Germany.
C3 Weizmann Institute of Science; Max Planck Society; Weizmann Institute of
   Science; Max Planck Society
RP Schroeder, M; Chen, A (corresponding author), Max Planck Inst Psychiat, Dept Stress Neurobiol & Neurogenet, D-80804 Munich, Germany.
EM marianaschroeder.mail@gmail.com; alon_chen@psych.mpg.de
RI Jakovcevski, Mira/N-2430-2019; Schroeder, Mariana/AAA-9216-2020;
   BEN-DOR, SHIFRA/M-6718-2019; Ben-Dor, Shifra/K-1675-2012; Roeh,
   Simone/JKI-0478-2023
OI Ben-Dor, Shifra/0000-0001-9604-1939; Roeh, Simone/0000-0002-7450-0871;
   Schroeder, Mariana/0000-0002-9517-4243; Jakovcevski,
   Mira/0000-0003-2262-823X
FU European Research Council [260463]; Israel Science Foundation [1565/15,
   1916/12]; ERANET Program; Chief Scientist Office of the Israeli Ministry
   of Health [3-11389]; Federal Ministry of Education and Research
   [01KU1501A]; I-CORE Program of the Planning and Budgeting Committee;
   Nella and Leon Benoziyo Center for Neurological Diseases; Henry Chanoch
   Krenter Institute for Biomedical Imaging and Genomics; Perlman Family
   Foundation; Adelis Foundation; Pratt Foundation; Irving I. Moskowitz
   Foundation; NARSAD [22809]
FX We thank Mr. Sharon Ovadia for his devoted assistance with animal care.
   This work was supported by: an FP7 Grant from the European Research
   Council (260463, A.C.); a research grant from the Israel Science
   Foundation (1565/15, A.C.); the ERANET Program, supported by the Chief
   Scientist Office of the Israeli Ministry of Health (3-11389, A.C.); the
   project was funded by the Federal Ministry of Education and Research
   under the funding code 01KU1501A (A.C.); research support from Roberto
   and Renata Ruhman (A.C.); research support from Bruno and Simone Licht;
   I-CORE Program of the Planning and Budgeting Committee and The Israel
   Science Foundation (grant no. 1916/12, A.C.); the Nella and Leon
   Benoziyo Center for Neurological Diseases (A.C.); the Henry Chanoch
   Krenter Institute for Biomedical Imaging and Genomics (A.C.); the
   Perlman Family Foundation, founded by Louis L. and Anita M. Perlman
   (A.C.); the Adelis Foundation (A.C.); the Marc Besen and the Pratt
   Foundation and the Irving I. Moskowitz Foundation (A.C.). MJ was
   supported by a NARSAD young investigator (grant no 22809).
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NR 91
TC 15
Z9 17
U1 0
U2 8
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2212-8778
J9 MOL METAB
JI Mol. Metab.
PD NOV
PY 2018
VL 17
BP 1
EP 16
DI 10.1016/j.molmet.2018.08.005
PG 16
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism
GA GX4GS
UT WOS:000447687500001
PM 30174229
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Chan, SMH
   Lau, YS
   Miller, AA
   Ku, JM
   Potocnik, S
   Ye, JM
   Woodman, OL
   Herbert, TP
AF Chan, Stanley M. H.
   Lau, Yeh-Siang
   Miller, Alyson A.
   Ku, Jacqueline M.
   Potocnik, Simon
   Ye, Ji-Ming
   Woodman, Owen L.
   Herbert, Terence P.
TI Angiotensin II Causes β-Cell Dysfunction Through an ER
   Stress-Induced Proinflammatory Response
SO ENDOCRINOLOGY
LA English
DT Article
ID ENDOPLASMIC-RETICULUM STRESS; CONVERTING ENZYME-INHIBITORS; UNFOLDED
   PROTEIN RESPONSE; ISLET BLOOD-FLOW; INSULIN-SECRETION; NLRP3
   INFLAMMASOME; GLUCOSE-METABOLISM; DISPOSITION INDEX; PANCREATIC-ISLETS;
   RECEPTOR BLOCKER
AB The metabolic syndrome is associated with an increase in the activation of the renin angiotensin system, whose inhibition reduces the incidence of new-onset diabetes. Importantly, angiotensin II (AngII), independently of its vasoconstrictor action, causes beta-cell inflammation and dysfunction, which may be an early step in the development of type 2 diabetes. The aim of this study was to determine how AngII causes beta-cell dysfunction. Islets of Langerhans were isolated from C57BL/6J mice that had been infused with AngII in the presence or absence of taurine-conjugated ursodeoxycholic acid (TUDCA) and effects on endoplasmic reticulum (ER) stress, inflammation, and beta-cell function determined. The mechanism of action of AngII was further investigated using isolated murine islets and clonal beta cells. We show that AngII triggers ER stress, an increase in the messenger RNA expression of proinflammatory cytokines, and promotes beta-cell dysfunction in murine islets of Langerhans both in vivo and ex vivo. These effects were significantly attenuated by TUDCA, an inhibitor of ER stress. We also show that AngII-induced ER stress is required for the increased expression of proinflammatory cytokines and is caused by reactive oxygen species and IP3 receptor activation. These data reveal that the induction of ER stress is critical for AngII-induced beta-cell dysfunction and indicates how therapies that promote ER homeostasis may be beneficial in the prevention of type 2 diabetes.
C1 [Chan, Stanley M. H.; Miller, Alyson A.; Ku, Jacqueline M.; Potocnik, Simon; Ye, Ji-Ming; Woodman, Owen L.; Herbert, Terence P.] RMIT Univ, Sch Hlth & Biomed Sci, Bundoora, Vic 3083, Australia.
   [Lau, Yeh-Siang] Univ Malaya, Fac Med, Dept Pharmacol, Kuala Lumpur 50603, Malaysia.
   [Herbert, Terence P.] Univ Lincoln, Joseph Banks Labs, Coll Sci, Sch Pharm, Green Lane, Lincoln LN6 7DL, Lincs, England.
C3 Royal Melbourne Institute of Technology (RMIT); Universiti Malaya;
   University of Lincoln
RP Herbert, TP (corresponding author), Univ Lincoln, Joseph Banks Labs, Coll Sci, Sch Pharm, Green Lane, Lincoln LN6 7DL, Lincs, England.
EM therbert@lincoln.ac.uk
RI Woodman, Owen/H-7297-2019; Lau, Yeh Siang/D-2136-2016
OI Herbert, Terence/0000-0001-5402-0814; Lau, Yeh
   Siang/0000-0002-1770-3058; Woodman, Owen/0000-0003-3759-1396; Chan,
   Stanley/0000-0002-4103-9441
FU School of Health and Biomedical Sciences, Royal Melbourne Institute of
   Technology University; Australian Endeavour Scholarships and
   Fellowships; Ministry of Higher Education [H-20001-00-E000055]
FX This work was supported by the School of Health and Biomedical Sciences,
   Royal Melbourne Institute of Technology University. Y.-S.L. was
   supported by the Australian Endeavour Scholarships and Fellowships and
   Ministry of Higher Education High Impact Research Grant
   H-20001-00-E000055.
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NR 55
TC 25
Z9 27
U1 0
U2 11
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0013-7227
EI 1945-7170
J9 ENDOCRINOLOGY
JI Endocrinology
PD OCT
PY 2017
VL 158
IS 10
BP 3162
EP 3173
DI 10.1210/en.2016-1879
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA FI9BO
UT WOS:000412298700011
PM 28938442
OA Bronze, Green Accepted
DA 2025-06-11
ER

PT J
AU Jeste, DV
   Maglione, JE
AF Jeste, Dilip V.
   Maglione, Jeanne E.
TI Treating Older Adults With Schizophrenia: Challenges and Opportunities
SO SCHIZOPHRENIA BULLETIN
LA English
DT Article
DE schizophrenia; aging; antipsychotics; psychosocial treatments;
   cognition; psychosis
ID SEVERE MENTAL-ILLNESS; ATYPICAL ANTIPSYCHOTICS; RANDOMIZED-TRIAL;
   PEOPLE; AGE
AB Schizophrenia affects people of all age groups. Treatment plans for older adults with schizophrenia must consider the effects of age on the course of the illness as well as on the response to antipsychotics and to psychosocial interventions. Positive symptoms of schizophrenia tend to become less severe, substance abuse becomes less common, and mental health functioning often improves. Hospitalizations are more likely to be due to physical problems rather than psychotic relapses. Physical comorbidity is a rule, however, and older age is a risk factor for most side effects of antipsychotics, including metabolic syndrome and movement disorders. We recently reported high rates of adverse events and medication discontinuation along with limited effectiveness of commonly used atypical antipsychotics in older adults. Psychosocial interventions such as cognitive behavioral social skills training are efficacious in improving functioning in older adults with schizophrenia. In formulating treatment plans for this population, a balanced approach combining cautious antipsychotic medication use with psychosocial interventions is recommended. Antipsychotic medications should generally be used in lower doses in older adults. Close monitoring for side effects and effectiveness of the medications and a watchful eye on their risk:benefit ratio are critical. In a minority of patients it may be possible to discontinue medications. Sustained remission of schizophrenia after decades of illness is not rare, especially in persons who receive appropriate treatment and psychosocial supportuthere can be light at the end of a long tunnel.
C1 [Jeste, Dilip V.; Maglione, Jeanne E.] Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA.
C3 University of California System; University of California San Diego
RP Jeste, DV (corresponding author), 9500 Gilman Dr 0664, La Jolla, CA 92093 USA.
EM djeste@ucsd.edu
FU National Institute of Mental Health [T32 MH019934-18, R01 MH094151, P30
   MH080002, UL1RR031980]
FX National Institute of Mental Health (T32 MH019934-18, R01 MH094151, P30
   MH080002, and UL1RR031980).
CR Auslander LA, 2004, AM J PSYCHIAT, V161, P1490, DOI 10.1176/appi.ajp.161.8.1490
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NR 15
TC 57
Z9 61
U1 1
U2 29
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0586-7614
J9 SCHIZOPHRENIA BULL
JI Schizophr. Bull.
PD SEP
PY 2013
VL 39
IS 5
BP 966
EP 968
DI 10.1093/schbul/sbt043
PG 3
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 212HD
UT WOS:000323972700008
PM 23552180
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Wu, SH
   Shu, XO
   Chow, WH
   Xiang, YB
   Zhang, XL
   Cai, QY
   Li, HL
   Milne, G
   Wen, WQ
   Ji, BT
   Rothman, N
   Gao, YT
   Zheng, W
   Yang, G
AF Wu, Sheng-Hui
   Shu, Xiao-Ou
   Chow, Wong-Ho
   Xiang, Yong-Bing
   Zhang, Xianglan
   Cai, Qiuyin
   Li, Hong-Lan
   Milne, Ginger
   Wen, Wanqing
   Ji, Bu-Tian
   Rothman, Nathaniel
   Gao, Yu-Tang
   Zheng, Wei
   Yang, Gong
TI Adiposity and fat distribution in relation to inflammation and oxidative
   stress in a relatively lean population of Chinese women
SO DISEASE MARKERS
LA English
DT Article
DE Adiposity; inflammation; oxidative stress; biomarker
ID C-REACTIVE PROTEIN; CORONARY-HEART-DISEASE; INSULIN-RESISTANCE;
   METABOLIC SYNDROME; OBESITY; MARKERS; HEALTHY; RISK; F-2-ISOPROSTANES;
   INDEX
AB OBJECTIVES: This study evaluated associations of various anthropometric measures of adiposity with a panel of inflammatory and oxidative stress markers in a relatively lean population of Chinese women.
   METHODS: This analysis included 1,005 Chinese women aged 40-70 years. Plasma concentrations of inflammatory and oxidative stress markers were measured. Anthropometric measurements were taken by trained interviewers.
   RESULTS: Body mass index (BMI), waist circumference (WC), and waist-to-height ratio (WHtR) were all positively and linearly associated with the inflammatory markers, CRP, TNF-alpha, soluble TNF-receptor 1 (sTNF-R1), and IL-6. A significant positive association of these measures of adiposity with the oxidative stress marker F-2-IsoP-M, a metabolite of F-2-IsoPs, but with not F-2-IsoPs was found. Differences in biomarkers between extreme quartiles of anthropometric measurements varied widely, ranging from 9.7% for sTNF-R1 to 162.0% for CRP. For each specific biomarker, various anthropometric measurements exhibited similar ability to explain variations in the biomarker, with the biggest partial r(2)(11%) observed for CRP.
   CONCLUSIONS: This study suggests that both general adiposity (measured by BMI) and central adiposity (measured by WC and WHtR) are positively and similarly associated with various markers of inflammation and oxidative stress in relatively lean Chinese women. The metabolite F-2-IsoP-M of F-2-IsoPs may be a better marker of in vivo oxidative stress than its parent compounds.
C1 [Wu, Sheng-Hui; Shu, Xiao-Ou; Zhang, Xianglan; Cai, Qiuyin; Wen, Wanqing; Zheng, Wei; Yang, Gong] Vanderbilt Univ, Med Ctr, Dept Med, Div Epidemiol, Nashville, TN 37203 USA.
   [Chow, Wong-Ho; Ji, Bu-Tian; Rothman, Nathaniel] NCI, Div Canc Epidemiol & Genet, NIH, DHHS, Bethesda, MD 20892 USA.
   [Xiang, Yong-Bing; Li, Hong-Lan; Gao, Yu-Tang] Shanghai Canc Inst, Shanghai, Peoples R China.
   [Milne, Ginger] Vanderbilt Univ, Med Ctr, Dept Med, Div Clin Pharmacol, Nashville, TN 37203 USA.
C3 Vanderbilt University; National Institutes of Health (NIH) - USA; NIH
   National Cancer Institute (NCI); NIH National Cancer Institute- Division
   of Cancer Epidemiology & Genetics; Shanghai Jiao Tong University;
   Vanderbilt University
RP Yang, G (corresponding author), Vanderbilt Univ, Med Ctr, Dept Med, Div Epidemiol, 2525 West End Ave,Suite 600 IMPH, Nashville, TN 37203 USA.
EM Gong.Yang@Vanderbilt.edu
RI Wu, Shenghui/KBC-4561-2024; Shu, Xiao'Ou/KPA-5613-2024; Yang,
   Gong/KLD-0007-2024; Zheng, Wei/O-3351-2013; Li, Li/T-4353-2017;
   Stefanadis, Christodoulos/ABH-2232-2020; Milne, Ginger/D-7648-2014
OI Stefanadis, Christodoulos/0000-0001-5974-6454; Wu,
   Shenghui/0000-0003-0505-086X; Milne, Ginger/0000-0003-3890-151X; ,
   Gong/0000-0002-7006-5825
FU US National Institute of Health [R01CA122364, R37CA070867, R01HL095931,
   N02 CP1101066]; Vanderbilt-Ingram Cancer Center [P30 CA68485]; National
   Cancer Institute [ZIACP010123] Funding Source: NIH RePORTER
FX This study was supported by US National Institute of Health (grants
   R01CA122364 to G. Yang, R37CA070867 to W. Zheng, R01HL095931 to X.
   Zhang, and N02 CP1101066 to X.O. Shu). The plasma and urine sample
   preparation was performed at the Survey and Biospecimen Shared Resource,
   which is supported in part by the Vanderbilt-Ingram Cancer Center (P30
   CA68485).
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NR 42
TC 10
Z9 10
U1 0
U2 6
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 0278-0240
EI 1875-8630
J9 DIS MARKERS
JI Dis. Markers
PY 2013
VL 34
IS 4
BP 279
EP 293
DI 10.1155/2013/437076
PG 15
WC Biotechnology & Applied Microbiology; Genetics & Heredity; Medicine,
   Research & Experimental; Pathology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Genetics & Heredity; Research &
   Experimental Medicine; Pathology
GA 116AG
UT WOS:000316853500007
PM 23396296
OA Green Accepted, hybrid
DA 2025-06-11
ER

PT J
AU Fossum, E
   Hoieggen, A
   Reims, H
   Moan, A
   Rostrup, M
   Eide, I
   Kjeldsen, S
AF Fossum, E
   Hoieggen, A
   Reims, H
   Moan, A
   Rostrup, M
   Eide, I
   Kjeldsen, S
TI High screening blood pressure is related to sympathetic nervous system
   activity and insulin resistance in healthy young men
SO BLOOD PRESSURE
LA English
DT Article
DE blood pressure; catecholamines; hypertension; insulin resistance
ID CARDIOVASCULAR REACTIVITY; HYPERTENSION; SENSITIVITY; RESPONSES;
   AWARENESS; STRESS; HYPERINSULINEMIA; EPINEPHRINE; RELEASE; DISEASE
AB The cardiovascular metabolic syndrome is characterized by the presence of several cardiovascular risk factors, including blood pressure (BP) elevation. We aimed to study the relation between mental stress, plasma catecholamines, BP and BP responses to mental stress in healthy young Caucasian men selected from different levels of screening BP. We included 98 men with high and 22 men with normal screening BP. They were examined at baseline in the laboratory, during a hyperinsulinemic, isoglycemic glucose clamp and during mental stress. At baseline in the laboratory, the men with high screening BP were characterized by elevated BP ( p < 0.005) and plasma catecholamines ( p < 0.05), but unaltered serum lipid levels compared to men with normal screening BP. After 2 h rest the differences almost disappeared, but could be reproduced during a mental arithmetic stress test. The men with elevated screening BP had significantly higher fasting glucose ( p = 0.01) and lower insulin sensitivity ( p < 0.005). In a multiple regression model, norepinephrine during mental stress (R-2 = 0.10, p < 0.05) was the main variable to retrospectively explain allocation to the normal or high screening BP group. In conclusion, young healthy men with elevated screening BP are characterized by increased sympathetic activity and insulin resistance. Norepinephrine during mental stress is the main variable to explain allocation to the normal or elevated screening BP group. We have shown that one single screening BP measurement predicts insulin resistance and elevated fasting glucose in this cohort.
C1 Ullevaal Univ Hosp, Dept Cardiol, NO-0407 Oslo, Norway.
   Ullevaal Univ Hosp, Dept Nephrol, Oslo, Norway.
   Univ Michigan, Div Hypertens, Ann Arbor, MI 48109 USA.
C3 University of Oslo; University of Oslo; University of Michigan System;
   University of Michigan
RP Fossum, E (corresponding author), Ullevaal Univ Hosp, Dept Cardiol, NO-0407 Oslo, Norway.
EM eigil.fossum@ioks.uio.no
RI Kjeldsen, Sverre/S-1774-2018
OI Reims, Henrik/0000-0002-2018-7787
CR Björntorp P, 2001, SCAND CARDIOVASC J, V35, P172, DOI 10.1080/140174301750305045
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NR 26
TC 22
Z9 23
U1 0
U2 0
PU TAYLOR & FRANCIS AS
PI OSLO
PA CORT ADELERSGT 17, PO BOX 2562, SOLLI, 0202 OSLO, NORWAY
SN 0803-7051
J9 BLOOD PRESSURE
JI Blood Pressure
PD APR
PY 2004
VL 13
IS 2
BP 89
EP 94
DI 10.1080/08037050310031008
PG 6
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 815EB
UT WOS:000221024500005
PM 15182111
OA Bronze
DA 2025-06-11
ER

PT J
AU Al-Shaar, L
   Vercammen, K
   Lu, C
   Richardson, S
   Tamez, M
   Mattei, J
AF Al-Shaar, Laila
   Vercammen, Kelsey
   Lu, Chang
   Richardson, Scott
   Tamez, Martha
   Mattei, Josiemer
TI Health effects and Public Health Concerns of energy Drink Consumption in
   the United States: A Mini-Review
SO FRONTIERS IN PUBLIC HEALTH
LA English
DT Review
DE energy drinks; beverages; review; health effects; food policy;
   regulation
ID SUGAR-SWEETENED BEVERAGES; RED-BULL; METABOLIC SYNDROME; SUBSTANCE USE;
   YOUNG-ADULTS; WEIGHT-GAIN; ADOLESCENTS; PERFORMANCE; CHILDREN; RISK
AB As energy drink consumption continues to grow worldwide and within the United States, it is important to critically examine the nutritional content and effects on population health of these beverages. This mini-review summarizes the current scientific evidence on health consequences from energy drink consumption, presents relevant public health challenges, and proposes recommendations to mitigate these issues. Emerging evidence has linked energy drink consumption with a number of negative health consequences such as risk-seeking behaviors, poor mental health, adverse cardiovascular effects, and metabolic, renal, or dental conditions. Despite the consistency in evidence, most studies are of cross-sectional design or focus almost exclusively on the effect of caffeine and sugar, failing to address potentially harmful effects of other ingredients. The negative health effects associated with energy drinks (ED) are compounded by a lack of regulatory oversight and aggressive marketing by the industry toward adolescents. Moreover, the rising trend of mixing ED with alcohol presents a new challenge that researchers and public health practitioners must address further. To curb this growing public health issue, policy makers should consider creating a separate regulatory category for ED, setting an evidence-based upper limit on caffeine, restricting sales of ED, and regulating existing ED marketing strategies, especially among children and adolescents.
C1 [Al-Shaar, Laila; Richardson, Scott; Tamez, Martha; Mattei, Josiemer] Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA.
   [Al-Shaar, Laila; Richardson, Scott] Harvard Univ, Grad Sch Arts & Sci, Populat Hlth Sci Program, Cambridge, MA 02138 USA.
   [Vercammen, Kelsey; Lu, Chang] Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA.
C3 Harvard University; Harvard T.H. Chan School of Public Health; Harvard
   University; Harvard University; Harvard T.H. Chan School of Public
   Health
RP Mattei, J (corresponding author), Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA.
EM jmattei@hsph.harvard.edu
RI Mattei, Josiemer/H-1800-2016
OI Mattei, Josiemer/0000-0001-5424-8245; Al-Shaar,
   Laila/0000-0003-2774-3464; Tamez, Martha/0000-0003-3164-1647
FU NIH-NHLBI (HHS/United States) CVD Epidemiology Training Program in
   Behavior; Environment and Global Health [T32 HL098048]; National Council
   of Science and Technology (CONACyT, Mexico); NIH-NHLBI Mentored Career
   Development Award [K01-HL120951]
FX SR was supported by the NIH-NHLBI (HHS/United States) CVD Epidemiology
   Training Program in Behavior, the Environment and Global Health (grant
   number T32 HL098048). MT was supported by the National Council of
   Science and Technology (CONACyT, Mexico). JM was supported by a
   NIH-NHLBI Mentored Career Development Award to Promote Faculty Diversity
   in Biomedical Research (grant number K01-HL120951).
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NR 72
TC 69
Z9 73
U1 3
U2 55
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 2296-2565
J9 FRONT PUBLIC HEALTH
JI Front. Public Health
PD AUG 31
PY 2017
VL 5
AR 225
DI 10.3389/fpubh.2017.00225
PG 6
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA FH2EL
UT WOS:000410951500001
PM 28913331
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Espinosa, A
   Valenzuela, R
   González-Mañán, D
   D'Espessailles, A
   Gormaz, JG
   Barrera, C
   Tapia, G
AF Espinosa, Alejandra
   Valenzuela B, Rodrigo
   Gonzalez-Manan, Daniel
   D'Espessailles T, Amanda
   Guillermo Gormaz, Juan
   Barrera R, Cynthia
   Tapia O, Gladys
TI Prevention of liver steatosis through fish oil supplementation:
   correlation of oxidative stress with insulin resistance and liver fatty
   acid content
SO ARCHIVOS LATINOAMERICANOS DE NUTRICION
LA English
DT Article
DE Docosahexaenoic acid; eicosapentaenoic acid; insulin resistance; n-3
   fatty acids; non-alcoholic fatty liver disease; oxidative stress
ID METABOLIC SYNDROME; OMEGA-3-FATTY-ACIDS; DISEASE
AB Non-alcoholic fatty liver disease (NAFLD) is triggered by a nutritional-metabolic alteration characterized by triacylglicerides acumulation, insulin resistance (IR), oxidative stress and depletion of polyunsaturated fatty acid (PUFA). The n-3 PUFA, such as eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids, would be hepatoprotective against the development of NAFLD by stimulating lipolysis and inhibit lipogenesis. So, fish oil supplementation (EPA + DHA) prevents HFD-induced NAFLD. In this context, the aim of this study is to evaluate the correlation between liver oxidative stress with IR and levels of PUFA in supplemented mice. Male mice C57BL/6J (n=9) were fed for 12th week: a) control diet (20% protein, 70% carbohydrate, 10% lipids), b) control diet and fish oil supplementation (200 mg EPA+DHA/kg/day), c) high fat diet (20% protein, 20% carbohydrate, 60% lipids), and d) high fat diet and fish oil supplementation. Liver steatosis (histology), insulin resistance (HOMA), liver oxidative stress (GSH/GSSG, carbonyl protein and 8-isoprostanes) and liver fatty acid content were evaluated. The significant decrease in liver oxidative stress parameters (p<0.05, ANOVA followed by Newman Keuls test) were correlated (Pearson test) with HOMA and levels of PUFA, along with the hepatoprotection observed. It concludes that prevention of NAFLD by supplementation with fish oil (EPA+DHA) is dependent of the prevention of liver oxidative stress, IR and PUFA depletion.
C1 [Espinosa, Alejandra; Valenzuela B, Rodrigo; Gonzalez-Manan, Daniel; D'Espessailles T, Amanda; Guillermo Gormaz, Juan; Barrera R, Cynthia; Tapia O, Gladys] Univ Chile, Fac Med, Inst Biomed Sci, Med Technol Sch,Nutr & Dietet Sch,Mol & Clin Phar, Santiago, Chile.
C3 Universidad de Chile
RP Espinosa, A (corresponding author), Univ Chile, Fac Med, Inst Biomed Sci, Med Technol Sch,Nutr & Dietet Sch,Mol & Clin Phar, Santiago, Chile.
RI Espinosa, Alejandra/ISB-7050-2023; Barrera, Cynthia/I-7108-2015
OI Barrera, Cynthia/0000-0002-7762-5696
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NR 23
TC 12
Z9 13
U1 0
U2 6
PU ARCHIVOS LATINOAMERICANOS NUTRICION
PI CARACAS
PA APARTADO 62778 CHACAO, AVENIDA FRANCISCO MIRANDA, CARACAS 1060,
   VENEZUELA
SN 0004-0622
J9 ARCH LATINOAM NUTR
JI Arch. Latinoam. Nutr.
PY 2013
VL 63
IS 1
BP 29
EP 36
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA AN5JN
UT WOS:000340626900004
PM 24167955
DA 2025-06-11
ER

PT J
AU Kitagawa, T
   Higuchi, Y
   Todo, E
   Ueda, T
   Ando, S
   Murakami, T
AF Kitagawa, Tomomi
   Higuchi, Yumi
   Todo, Emiko
   Ueda, Tetsuya
   Ando, Suguru
   Murakami, Tatsunori
TI Tailored feedback reduced prolonged sitting time and improved the health
   of housewives: a single-blind randomized controlled pilot study
SO WOMEN & HEALTH
LA English
DT Article
DE Health-related quality of life; housewives; physical activity; prolonged
   sitting
ID PHYSICAL-ACTIVITY LEVEL; ALL-CAUSE; SEDENTARY BEHAVIORS; METABOLIC
   SYNDROME; WOMEN; ASSOCIATIONS; POPULATION; MORTALITY; EXERCISE; OBESITY
AB Reducing sitting time, independent of physical activity, is important for health. However, few reports have been published regarding physical activity of housewives compared to that of employed women. We examined strategies to shorten housewives' sitting time using a single-blind randomized controlled trial. Forty-eight housewives (38.0 +/- 4.5 years old) were randomly assigned to one of three groups: pamphlet, self-feedback, and tailored feedback groups. All participants received a pamphlet describing the risks of prolonged sitting. The self-feedback and tailored feedback groups were also given feedback on sitting time by a smartphone application. The tailored feedback group received individual suggestions regarding lifestyle to shorten sitting time. We measured physical activity using an accelerometer and health-related quality of life using the Short-Form 8. The longest prolonged sitting time significantly decreased over time, a significant reduction was observed after the intervention only in the tailored feedback group. Vitality, mental health, and role emotional components of health-related quality of life showed a significant improvement with time but no significant differences were observed among the study groups. We suggested an easy approach to shortening prolonged sitting time in housewives using a pamphlet and feedback by smartphone. However, tailored consulting was necessary to yield a more effective result.
C1 [Kitagawa, Tomomi; Higuchi, Yumi; Todo, Emiko; Ueda, Tetsuya; Ando, Suguru; Murakami, Tatsunori] Osaka Prefecture Univ, Grad Sch Comprehens Rehabil, 3-7-30 Habikino, Habikino, Osaka 5838555, Japan.
   [Kitagawa, Tomomi] Shijonawate Gakuen Unvers, Fac Rehabil, Daito City, Osaka, Japan.
C3 Osaka Metropolitan University
RP Kitagawa, T (corresponding author), Osaka Prefecture Univ, Grad Sch Comprehens Rehabil, 3-7-30 Habikino, Habikino, Osaka 5838555, Japan.
EM t-kitagawa@reha.shijonawate-gakuen.ac.jp
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NR 34
TC 11
Z9 11
U1 0
U2 9
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 0363-0242
EI 1541-0331
J9 WOMEN HEALTH
JI Women Health
PD FEB 7
PY 2020
VL 60
IS 2
BP 212
EP 223
DI 10.1080/03630242.2019.1616043
EA MAY 2019
PG 12
WC Public, Environmental & Occupational Health; Women's Studies
WE Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; Women's Studies
GA JZ5HJ
UT WOS:000469138400001
PM 31113310
DA 2025-06-11
ER

PT J
AU Fond, G
   Godin, O
   Schürhoff, F
   Berna, F
   André, M
   Aouizerate, B
   Capdevielle, D
   Chereau, I
   D'Amato, T
   Dubertret, C
   Dubreucq, J
   Faget, C
   Lançon, C
   Leignier, S
   Mallet, J
   Misdrahi, D
   Passerieux, C
   Pignon, B
   Rey, R
   Szoke, A
   Urbach, M
   Vidailhet, P
   Leboyer, M
   Boyer, L
   Llorca, PM
AF Fond, G.
   Godin, O.
   Schurhoff, F.
   Berna, F.
   Andre, M.
   Aouizerate, B.
   Capdevielle, D.
   Chereau, I.
   D'Amato, T.
   Dubertret, C.
   Dubreucq, J.
   Faget, C.
   Lancon, C.
   Leignier, S.
   Mallet, J.
   Misdrahi, D.
   Passerieux, C.
   Pignon, B.
   Rey, R.
   Szoke, A.
   Urbach, M.
   Vidailhet, P.
   Leboyer, M.
   Boyer, L.
   Llorca, P. M.
CA FACE-SZ Grp
TI Confirmations, advances and recommendations for the daily care of
   schizophrenia based on the French national FACE-SZ cohort
SO PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
LA English
DT Review
DE Schizophrenia; Cohort; FACE-SZ; Daily practice; Recommendations
ID QUALITY-OF-LIFE; CHILDHOOD TRAUMA; RATING-SCALE; NICOTINE DEPENDENCE;
   COGNITIVE INSIGHT; LANGUAGE VERSION; VALIDATION; VALIDITY; RELIABILITY;
   DISORDERS
AB Background The National FondaMental Centers of Expertise (FACE) for Schizophrenia (SZ) have been created to shorten the gap between research and clinical practice.
   Objectives To synthetize in a review the 10-year findings issued from the FACE-SZ cohort analyses.
   Methods More than 1000 patients were evaluated in 10 expert centers since 2010 with a 2-day long comprehensive standardized battery including neuropsychological testes and physical health assessment and followed-up for 3years.
   Results 1. The phase 0 cross-sectional analyses have confirmed well-known data: over-prescription of first-generation antipsychotics, antipsychotic polytherapy and long-term benzodiazepine and under-prescription of clozapine, 13% of drug-induced parkinsonism, 18% of akathisia, a mean duration of untreated psychosis of 18months, one third of poorly-adherent patients, 24% of metabolic syndrome and 52% of current tobacco smokers with poor care for physical illnesses; a yearly mean financial cost of 15,000 euro/patient. 2. FACE-SZ also yielded additional data in insufficiently explored area: a half of major depression issues (among them one third of undiagnosed major depression and 44% of treated patients with unremitted depression), major depression having a strong impact on Quality of Life independently of negative symptoms, 22% of moderated to severe untreated physical pain. 3. FACE-SZ has explored emerging fields of research, including development of 4 stages- model of schizophrenia, chronic low-grade peripheral inflammation, latent Toxoplasma infection, hypovitaminosis D, and a model for relapse prediction at 2years.
   Discussion The associated factors and implications for public health programs were discussed. Based on the FACE-SZ findings and literature, the FACE-SZ group has yielded recommendations to improve daily care for schizophrenia and for future research.
C1 [Fond, G.; Godin, O.; Schurhoff, F.; Berna, F.; Andre, M.; Aouizerate, B.; Capdevielle, D.; Chereau, I.; D'Amato, T.; Dubertret, C.; Dubreucq, J.; Faget, C.; Lancon, C.; Leignier, S.; Mallet, J.; Misdrahi, D.; Passerieux, C.; Pignon, B.; Rey, R.; Szoke, A.; Urbach, M.; Leboyer, M.; Boyer, L.; Llorca, P. M.] Fdn FondaMental, Creteil, France.
   [Schurhoff, F.; Pignon, B.; Szoke, A.; Leboyer, M.] Univ Paris Est Creteil, Pole Psychiat Hop Univ H Mondor, DHU Pe PSY, INSERM,U955,Equipe Psychiat Translat, Creteil, France.
   [Fond, G.; Faget, C.; Lancon, C.; Boyer, L.] Aix Marseille Univ, Fac Med Secteur, CEReSS Ctr Etud & Rech Serv Sante & Qualite Vie, EA 3279,LaTimone, 27 Blvd Jean Moulin, F-13005 Marseille, France.
   [Aouizerate, B.] Univ Bordeaux, Ctr Hosp Charles Perrens, F-33076 Bordeaux, France.
   [Berna, F.; Vidailhet, P.] Univ Strasbourg, Hop Univ Strasbourg, INSERM, U1114,Federat Med Translat Strasbourg, Strasbourg, France.
   [Andre, M.; Capdevielle, D.] Univ Montpellier I, CHRU Montpellier, Hop Colombiere, Serv Univ Psychiat Adulte,INSERM, F-1061 Montpellier, France.
   [Chereau, I.; Llorca, P. M.] Univ Auvergne, CHU Clermont Ferrand, Fac Med, CMP B,EA 7280, BP 69, F-63003 Clermont Ferrand 1, France.
   [D'Amato, T.] Univ Claude Bernard Lyon 1, Ctr Rech Neurosci Lyon, Ctr Hosp Le Vinatier, CNRS,UMR5292,INSERM,U1028,Equipe PSYR2, Pole Est,95 Bd Pinel,BP 30039, F-69678 Bron, France.
   [Dubertret, C.; Mallet, J.] Univ Paris Diderot, Louis Mourier Hosp, AP HP, Sorbonne Paris Cite,INSERM,U894,Dept Psychiat, Colombes, France.
   [Dubreucq, J.; Leignier, S.] CH Alpes Isere, Ctr Referent Rehabil Psychosociale, Grenoble, France.
   [Passerieux, C.; Urbach, M.] Univ Versailles St Quentin En Yvelines, Ctr Hosp Versailles, UFR Sci Sante Simone Veil, Serv Psychiat & Daddictol Adulte,HANDIReSP,EA 404, Versailles, France.
   [Aouizerate, B.] Univ Bordeaux, INRA, NutriNeuro, U1286, F-33076 Bordeaux, France.
   [Misdrahi, D.] CNRS, INCIA, UMR 5287, Paris, France.
C3 Universite Paris-Est-Creteil-Val-de-Marne (UPEC); Institut National de
   la Sante et de la Recherche Medicale (Inserm); Assistance Publique
   Hopitaux Paris (APHP); Hopital Universitaire Henri-Mondor - APHP;
   Aix-Marseille Universite; Universite de Bordeaux; CHU Strasbourg;
   Universite de Lorraine; Institut National de la Sante et de la Recherche
   Medicale (Inserm); Universites de Strasbourg Etablissements Associes;
   Universite de Strasbourg; Universite de Montpellier; CHU de Montpellier;
   Institut National de la Sante et de la Recherche Medicale (Inserm);
   Universite Clermont Auvergne (UCA); CHU Clermont Ferrand; Centre
   National de la Recherche Scientifique (CNRS); CNRS - National Institute
   for Biology (INSB); Institut National de la Sante et de la Recherche
   Medicale (Inserm); Universite Claude Bernard Lyon 1; Universite Jean
   Monnet; Universite Paris Cite; Assistance Publique Hopitaux Paris
   (APHP); Hopital Universitaire Louis-Mourier - APHP; Institut National de
   la Sante et de la Recherche Medicale (Inserm); Centre Hospitalier de
   Versailles; Universite Paris Saclay; Universite de Bordeaux; Institut
   National de la Sante et de la Recherche Medicale (Inserm); INRAE; Centre
   National de la Recherche Scientifique (CNRS); CNRS - National Institute
   for Biology (INSB)
RP Fond, G (corresponding author), Aix Marseille Univ, Fac Med Secteur, CEReSS Ctr Etud & Rech Serv Sante & Qualite Vie, EA 3279,LaTimone, 27 Blvd Jean Moulin, F-13005 Marseille, France.
EM guillaume.fond@ap-hm.fr; guillaume.fond@ap-hm.fr
RI Fond, Guillaume/D-7646-2011; Capdevielle, Delphine/HTO-4229-2023; Berna,
   Fabrice/J-2701-2019; Pignon, Baptiste/Y-1607-2019; Boyer,
   Laurent/E-5728-2016
OI Pignon, Baptiste/0000-0003-0526-3136; dubreucq,
   julien/0000-0003-4079-4194; Aouizerate, Bruno/0000-0002-7092-7747;
   Boyer, Laurent/0000-0003-1229-6622
FU fondation FondaMental; AP-HM (Assistance Publique des hopitaux de
   Marseille); Aix-Marseille University
FX This work was funded by fondation FondaMental, AP-HM (Assistance
   Publique des hopitaux de Marseille) and Aix-Marseille University.
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NR 66
TC 12
Z9 12
U1 0
U2 5
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0278-5846
EI 1878-4216
J9 PROG NEURO-PSYCHOPH
JI Prog. Neuro-Psychopharmacol. Biol. Psychiatry
PD JUL 13
PY 2020
VL 101
AR 109927
DI 10.1016/j.pnpbp.2020.109927
PG 9
WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA LZ0GH
UT WOS:000540909600006
PM 32173456
OA Bronze
DA 2025-06-11
ER

PT J
AU Sabin, CA
   Ryom, L
   De Wit, S
   Mocroft, A
   Phillips, AN
   Worm, SW
   Weber, R
   Monforte, AD
   Reiss, P
   Kamara, D
   El-Sadr, W
   Pradier, C
   Dabis, F
   Law, M
   Lundgren, J
AF Sabin, Caroline A.
   Ryom, Lene
   De Wit, Stephane
   Mocroft, Amanda
   Phillips, Andrew N.
   Worm, Signe W.
   Weber, Rainer
   Monforte, Antonella D'Arminio
   Reiss, Peter
   Kamara, David
   El-Sadr, Wafaa
   Pradier, Christian
   Dabis, Francois
   Law, Matthew
   Lundgren, Jens
CA D A D Study Grp
TI Associations between immune depression and cardiovascular events in HIV
   infection
SO AIDS
LA English
DT Article
DE bias; cardiovascular disease; CD4(+) lymphocyte count; myocardial
   infarction; stroke
ID COMBINATION ANTIRETROVIRAL THERAPY; MYOCARDIAL-INFARCTION RATES;
   CORONARY-HEART-DISEASE; T-CELL COUNTS; RISK-FACTORS; INDEPENDENT
   PREDICTORS; CEREBROVASCULAR EVENTS; METABOLIC SYNDROME; ATHEROSCLEROSIS
AB Objective:To consider associations between the latest/nadir CD4(+) cell count, and time spent with CD4(+) cell count less than 200cells/l (duration of immune depression), and myocardial infarction (MI), coronary heart disease (CHD), stroke, or cardiovascular disease (CVD) (CHD or stroke) in 33301 HIV-positive individuals.Design:Longitudinal cohort study.Methods:Analyses were undertaken using Poisson regression. To investigate whether analyses of stroke were robust to the type of endpoint, we additionally included stroke-like events and rejected strokes into the stroke endpoint.Results:Participants experienced 716 MI, 1056 CHD, 303 stroke, and 1284 CVD events. Whereas there was no evidence of a higher MI/CHD risk in those with lower latest/nadir CD4(+) cell counts after adjustment [current CD4(+)<100cells/l: relative rate (95% confidence interval) 0.96 (0.62-1.50) for MI, 0.89 (0.30-2.36) for CHD; nadir CD4(+)<100cells/l: 1.36 (0.57-3.23) for MI, 0.98 (0.45-2.16) for CHD], stroke and CVD rates were higher in those with a latest CD4(+) cell count less than 100cells/l [2.26 (1.29-3.94) and 1.14 (0.84-1.56), respectively]. All events occurred less frequently in those who had not experienced immune depression, although evidence for a linear association with duration of immune depression was weak. The association between stroke risk and the latest CD4(+) cell count strengthened as stroke-like and rejected strokes were included; conversely, associations with established stroke risk factors weakened.Conclusion:We do not find strong evidence that HIV-positive individuals with a low CD4(+) cell count are more likely to experience MI/CHD. Although strokes appear to occur more commonly at low CD4(+) cell counts, this may be partly explained by misclassification or other biases.
C1 [Sabin, Caroline A.; Mocroft, Amanda; Phillips, Andrew N.; Kamara, David] UCL, Res Dept Infect & Populat Hlth, London NW3 2PF, England.
   [Ryom, Lene; Worm, Signe W.; Lundgren, Jens] Univ Copenhagen, Copenhagen HIV Programme, Copenhagen, Denmark.
   [De Wit, Stephane] CHU St Pierre Hosp, Dept Infect Dis, Brussels, Belgium.
   [Weber, Rainer] Univ Zurich, Univ Zurich Hosp, Div Infect Dis & Hosp Epidemiol, Zurich, Switzerland.
   [Monforte, Antonella D'Arminio] Univ Milan, Hosp San Paolo, Milan, Italy.
   [Reiss, Peter] Univ Amsterdam, Acad Med Ctr, NL-1105 AZ Amsterdam, Netherlands.
   [Reiss, Peter] Stichting HIV Monitoring, Amsterdam, Netherlands.
   [El-Sadr, Wafaa] Columbia Univ, Harlem Hosp, ICAP, New York, NY USA.
   [Pradier, Christian] Ctr Hosp Univ, Dept Sante Publ, Nice, France.
   [Dabis, Francois] INSERM, Ctr INSERM Epidemiol & Biostat U897, Bordeaux, France.
   [Dabis, Francois] Univ Bordeaux Segalen, Inst Sante Publ Epidemiol Dev, Bordeaux, France.
   [Law, Matthew] Univ New S Wales, Kirby Inst, Sydney, NSW, Australia.
   [Lundgren, Jens] Univ Copenhagen Hosp, Rigshosp, Epidemiklinikken M5132, DK-2100 Copenhagen, Denmark.
C3 University of London; University College London; University of
   Copenhagen; Universite Libre de Bruxelles; University of Zurich;
   University Zurich Hospital; University of Milan; University of
   Amsterdam; Academic Medical Center Amsterdam; Columbia University; CHU
   Nice; CHU de Toulouse; Institut National de la Sante et de la Recherche
   Medicale (Inserm); Universite de Bordeaux; University of New South Wales
   Sydney; Kirby Institute; University of Copenhagen; Copenhagen University
   Hospital; Rigshospitalet
RP Sabin, CA (corresponding author), UCL, Res Dept Infect & Populat Hlth, Royal Free Campus,Rowland Hill St, London NW3 2PF, England.
EM c.sabin@ucl.ac.uk
RI Lundgren, Jens/AAE-6876-2019; DABIS, FRANCOIS/S-9298-2019; Weber,
   Rainer/D-5175-2012; Pradier, Christian/AFE-8255-2022; Phillips,
   Andrew/B-4427-2008; VELLA, STEFANO/D-4912-2015; Rijnders,
   Bart/AAB-2868-2019; Sabin, Caroline/C-2464-2008; Soriano,
   Vicente/O-5730-2018; Vandekerckhove, Linos/J-6420-2013
OI Martinez de Tejada, Begona/0000-0001-5737-3586; COSTANTINI,
   ANDREA/0000-0003-1588-7030; KATLAMA, CHRISTINE/0000-0002-5093-4800;
   VELLA, STEFANO/0000-0003-2347-5984; d'Arminio Monforte,
   Antonella/0000-0003-0073-1789; Torres, Ferran/0000-0002-7355-7913;
   Segala, Daniela/0000-0001-6133-0386; Rijnders, Bart/0000-0003-3343-9610;
   Sabin, Caroline/0000-0001-5173-2760; Lundgren, Jens/0000-0001-8901-7850;
   Soriano, Vicente/0000-0002-4624-5199; PERNO, CARLO
   FEDERICO/0000-0002-0825-5388; Ristola, Matti/0000-0001-5115-2811;
   Podlekareva, Daria/0000-0003-3187-0597; Ostergaard,
   Lars/0000-0003-2459-0511; Leen, Clifford/0000-0001-8439-7719; CAUDA,
   Roberto/0000-0002-1498-4229; Ippolito, Giuseppe/0000-0002-1076-2979;
   Powderly, William/0000-0001-7808-3086; Tebano,
   Gianpiero/0000-0003-1891-4823; Katzenstein, Terese
   L/0000-0002-2233-500X; Abrescia, Nicola/0000-0001-8513-6449; Law,
   Matthew/0000-0002-3540-8837; Ostergaard, Lars/0000-0002-7619-605X;
   Vandekerckhove, Linos/0000-0002-8600-1631
FU Highly Active Antiretroviral Therapy Oversight Committee (HAARTOC);
   European Agency for the Evaluation of Medicinal Products; United States
   Food and Drug Administration; Abbott Laboratories; Boehringer Ingelheim
   Pharmaceuticals Inc.; Bristol-Myers Squibb; Gilead Sciences Inc.; Viiv
   Healthcare; Merck Co Inc.; Pfizer Inc; F. Hoffman-LaRoche Ltd; Janssen
   Pharmaceuticals; Health Insurance Fund Council, Amstelveen, the
   Netherlands [CURE/97-46486]; Agence Nationale de Recherches sur le SIDA;
   Australian HIV Observational Database (AHOD); U.S. National Institutes
   of Health's National Institute of Allergy and Infectious Diseases
   (NIAID) [U01-AI069907]; Merck Sharp Dohme; Gilead Sciences; Roche;
   Pfizer; GlaxoSmithKline; Australian Government Department of Health and
   Ageing; Faculty of Medicine, The University of New South Wales; Fondo de
   Investigacion Sanitaria [FIS 99/0887]; Fundacion para la Investigacion y
   la Prevencion del SIDA en Espana [FIPSE 3171/00]; National Institute of
   Allergy and Infectious Diseases, National Institutes of Health
   [5U01AI042170-10, 5U01AI046362-03]; BIOMED 1 [CT94-1637]; BIOMED 2
   [CT97-2713]; European Commission [QLK2-2000-00773]; Swiss National
   Science Foundation
FX This work was supported by the Highly Active Antiretroviral Therapy
   Oversight Committee (HAARTOC), a collaborative committee with
   representation from academic institutions, the European Agency for the
   Evaluation of Medicinal Products, the United States Food and Drug
   Administration, the patient community, and all pharmaceutical companies
   with licensed anti-HIV drugs in the European Union: Abbott Laboratories,
   Boehringer Ingelheim Pharmaceuticals Inc., Bristol-Myers Squibb, Gilead
   Sciences Inc., Viiv Healthcare, Merck & Co Inc., Pfizer Inc, F.
   Hoffman-LaRoche Ltd, and Janssen Pharmaceuticals.Supported by a grant
   [grant number CURE/97-46486] from the Health Insurance Fund Council,
   Amstelveen, the Netherlands, to the AIDS Therapy Evaluation Project
   Netherlands (ATHENA); by a grant from the Agence Nationale de Recherches
   sur le SIDA [grant number Action Coordonnee no. 7, Cohortes], to the
   Aquitaine Cohort; The Australian HIV Observational Database (AHOD) is
   funded as part of the Asia Pacific HIV Observational Database, a program
   of The Foundation for AIDS Research, amfAR, and is supported in part by
   a grant from the U.S. National Institutes of Health's National Institute
   of Allergy and Infectious Diseases (NIAID) [grant number U01-AI069907]
   and by unconditional grants from Merck Sharp & Dohme; Gilead Sciences;
   Bristol-Myers Squibb; Boehringer Ingelheim Pharmaceuticals Inc.; Roche;
   Pfizer; GlaxoSmithKline; Janssen Pharmaceuticals. The Kirby Institute is
   funded by The Australian Government Department of Health and Ageing, and
   is affiliated with the Faculty of Medicine, The University of New South
   Wales. By grants from the Fondo de Investigacion Sanitaria [grant number
   FIS 99/0887] and Fundacion para la Investigacion y la Prevencion del
   SIDA en Espana [grant number FIPSE 3171/00], to the Barcelona
   Antiretroviral Surveillance Study (BASS); by the National Institute of
   Allergy and Infectious Diseases, National Institutes of Health [grants
   number 5U01AI042170-10, 5U01AI046362-03], to the Terry Beirn Community
   Programs for Clinical Research on AIDS (CPCRA); by grants from the
   BIOMED 1 [grant number CT94-1637] and BIOMED 2 [grant number CT97-2713]
   programs and the fifth framework program [grant number QLK2-2000-00773]
   of the European Commission and grants from Bristol-Myers Squibb,
   GlaxoSmithKline, Boehringer Ingelheim Pharmaceuticals Inc., and Roche,
   to the EuroSIDA study; by unrestricted educational grants of Abbott
   Laboratories, Bristol-Myers Squibb, Gilead Sciences Inc.,
   GlaxoSmithKline, Pfizer Inc., Janssen Pharmaceuticals to the Italian
   Cohort Naive to Antiretrovirals (The ICONA Foundation); and by a grant
   from the Swiss National Science Foundation, to the Swiss HIV Cohort
   Study (SHCS).
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NR 38
TC 50
Z9 56
U1 0
U2 20
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0269-9370
EI 1473-5571
J9 AIDS
JI Aids
PD NOV 13
PY 2013
VL 27
IS 17
BP 2735
EP 2748
DI 10.1097/01.aids.0000432457.91228.f3
PG 14
WC Immunology; Infectious Diseases; Virology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Infectious Diseases; Virology
GA 250HR
UT WOS:000326841800008
PM 23842128
OA Bronze
DA 2025-06-11
ER

PT J
AU Kim, EJ
   Lim, SY
   Lee, HJ
   Lee, JY
   Choi, S
   Kim, SY
   Kim, JM
   Shin, IS
   Yoon, JS
   Yang, SJ
   Kim, SW
AF Kim, Eun Jin
   Lim, So Young
   Lee, Hee Jae
   Lee, Ju-Yeon
   Choi, Seunggi
   Kim, Seon-Young
   Kim, Jae-Min
   Shin, Il-Seon
   Yoon, Jin-Sang
   Yang, Soo Jin
   Kim, Sung-Wan
TI Low dietary intake of n-3 fatty acids, niacin, folate, and vitamin C in
   Korean patients with schizophrenia and the development of dietary
   guidelines for schizophrenia
SO NUTRITION RESEARCH
LA English
DT Article
DE Dietary guidelines; Folate; N-3 PUFAs; Niacin; Schizophrenia
ID PSYCHOTIC DISORDERS; CLINICAL-PRACTICE; SUPPLEMENTATION; DOPAMINE;
   OMEGA-3-FATTY-ACIDS; PREVENTION
AB Inappropriate dietary intake and poor nutritional status are reported to be associated with metabolic syndrome and psychopathology in patients with schizophrenia. We hypothesized that inappropriate dietary habits and insufficient dietary intake of specific nutrients are associated with schizophrenia. To test the hypothesis, we assessed the dietary habits and nutritional intake of patients with schizophrenia and then developed suitable dietary guidelines. In total, 140 subjects (73 controls and 67 patients with schizophrenia from community mental health centers) were included, and dietary intakes were analyzed using a semi-quantitative food frequency questionnaire. As a result, the proportion of overweight or obese patients was significantly higher in schizophrenia subjects (64.2%) compared with control subjects (39.7%) (P = .004). The male schizophrenia patients had significantly lower dietary intakes of protein, polyunsaturated fatty acids (PUPAS), vitamin K, niacin, folate, and vitamin C than the male control subjects. In all multiple logistic regression models, subjects with the "low" dietary intake of protein, n-3 PUFAs, niacin, folate, and vitamin C had a significantly higher odds ratios for schizophrenia compared with those with the "high" dietary intake category of each nutrient. Therefore, maintenance of a healthy body weight and sufficient dietary intake of protein, PUFAs, niacin, folate, and vitamin C are recommended for Korean patients with schizophrenia. (C) 2017 Elsevier Inc. All rights reserved.
C1 [Kim, Eun Jin; Lim, So Young] Chonnam Natl Univ, Dept Food & Nutr, Gwangju 61186, South Korea.
   [Lee, Hee Jae; Yang, Soo Jin] Seoul Womens Univ, Dept Food & Nutr, Seoul 01797, South Korea.
   [Lee, Ju-Yeon; Kim, Seon-Young; Kim, Jae-Min; Shin, Il-Seon; Yoon, Jin-Sang; Kim, Sung-Wan] Chonnam Natl Univ, Med Sch, Dept Psychiat, 42 Jebong Ro, Gwangju 61469, South Korea.
   [Lee, Ju-Yeon; Kim, Sung-Wan] Gwangju Bukgu Community Mental Hlth Ctr, Gwangju 61261, South Korea.
   [Lee, Ju-Yeon; Kim, Sung-Wan] Gwangju Mental Hlth Commiss, Gwangju 61489, South Korea.
C3 Chonnam National University; Seoul Women's University; Chonnam National
   University
RP Yang, SJ (corresponding author), Seoul Womens Univ, Dept Food & Nutr, Seoul 01797, South Korea.; Kim, SW (corresponding author), Chonnam Natl Univ, Med Sch, Dept Psychiat, 42 Jebong Ro, Gwangju 61469, South Korea.
EM sjyang89@swu.ac.kr; swkim@chonnam.ac.kr
RI Lee, Jung-Seok/L-6826-2019; shin, i/JCE-1227-2023; KIM,
   Jae-Min/S-7637-2019
FU Ministry of Health & Welfare, Republic of Korea [HM15C1140]; National
   Research Foundation of Korea (NRF) - Ministry of Education
   [NRF-2017R1D1A1B03030617]; Ministry of Health Welfare; Gwangju
   Metropolitan city, Republic of Korea
FX This study was supported by a grant from the Korean Mental Health
   Technology R&D Project, Ministry of Health & Welfare, Republic of Korea
   (HM15C1140) and Basic Science Research Program through the National
   Research Foundation of Korea (NRF) funded by the Ministry of Education
   (NRF-2017R1D1A1B03030617 to SJY). The funders had no role in study
   design, data collection and analysis, decision to publish, or
   preparation of the manuscript. This research work was conducted as part
   of the Gwangju Mental Health Demonstration Project supported by Ministry
   of Health & Welfare and Gwangju Metropolitan city, Republic of Korea.
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NR 49
TC 23
Z9 24
U1 0
U2 8
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0271-5317
EI 1879-0739
J9 NUTR RES
JI Nutr. Res.
PD SEP
PY 2017
VL 45
BP 10
EP 18
DI 10.1016/j.nutres.2017.07.001
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA FL0DW
UT WOS:000413882600002
PM 29037327
DA 2025-06-11
ER

PT J
AU Kim, CJ
   Park, J
   Kang, SW
   Schlenk, EA
AF Kim, Chun-Ja
   Park, JeeWon
   Kang, Se-Won
   Schlenk, Elizabeth A.
TI Factors affecting aging cognitive function among community-dwelling
   older adults
SO INTERNATIONAL JOURNAL OF NURSING PRACTICE
LA English
DT Article
DE aging cognitive function; cardio-metabolic risks; depressive symptoms
ID DEPRESSIVE SYMPTOMS; RISK-FACTORS; METABOLIC SYNDROME; LATE-LIFE;
   FOLLOW-UP; DECLINE; IMPAIRMENT; PREVALENCE; DEMENTIA; SMOKING
AB Aim The study purpose was to determine factors affecting aging cognitive function of 3,645 community-dwelling older adults in Korea.
   Methods The Hasegawa Dementia Scale assessed aging cognitive function, blood analyses and anthropometrics assessed cardio-metabolic risk factors, and the Geriatric Depression Scale Short Form Korean Version assessed depressive symptoms.
   Results Participants with poor aging cognitive function were more likely to be in the late age group (75y) and currently smoking and have a medical history of stroke, high body mass index, and high level of depressive symptoms; they were also less likely to engage in regular meals and physical activities.
   Conclusion Regular meals and physical activities may be primary factors for clinical assessment to identify older adults at risk for aging cognitive function. With aging, depressive symptoms and other unhealthy lifestyle behaviours should be managed to prevent cognitive function disorders.
C1 [Kim, Chun-Ja; Park, JeeWon] Ajou Univ, Inst Nursing Sci, Coll Nursing, Suwon, South Korea.
   [Kang, Se-Won] Dongseo Univ, Dept Nursing, 47 Jurye Ro, Busan 47011, South Korea.
   [Schlenk, Elizabeth A.] Univ Pittsburgh, Sch Nursing, Pittsburgh, PA 15261 USA.
C3 Ajou University; Dongseo University; Pennsylvania Commonwealth System of
   Higher Education (PCSHE); University of Pittsburgh
RP Kang, SW (corresponding author), Dongseo Univ, Dept Nursing, 47 Jurye Ro, Busan 47011, South Korea.
EM swkang75@hotmail.com
RI Kim, Chun-Ja/HKF-2429-2023
OI KIM, Chun-Ja/0000-0002-7594-5418; Schlenk, Elizabeth/0000-0001-7361-1951
FU National Research Foundation of Korea [2016R1D1A1A09917287]
FX National Research Foundation of Korea, Grant/Award Number:
   2016R1D1A1A09917287
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NR 54
TC 5
Z9 5
U1 3
U2 12
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1322-7114
EI 1440-172X
J9 INT J NURS PRACT
JI Int. J. Nurs. Pract.
PD AUG
PY 2017
VL 23
IS 4
AR e12567
DI 10.1111/ijn.12567
PG 8
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA FE0KU
UT WOS:000407910000013
PM 28621053
DA 2025-06-11
ER

PT S
AU Wylie, K
AF Wylie, Kevan
BE Balon, R
TI Erectile dysfunction
SO SEXUAL DYSFUNCTION: THE BRAIN-BODY CONNECTION
SE Advances in Psychosomatic Medicine
LA English
DT Article; Book Chapter
ID SEXUAL DYSFUNCTION; SILDENAFIL CITRATE; DOUBLE-BLIND;
   CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; OPEN-LABEL; MEN;
   TESTOSTERONE; HEALTH; MANAGEMENT
AB Erectile dysfunction is a common problem affecting sexual function in men. Approximately one in 10 men over the age of 40 is affected by this condition and the incidence is age related. Erectile dysfunction is a sentinel marker for several reversible conditions including peripheral and coronary vascular disease, hypertension and diabetes mellitus. Endothelial dysfunction is a common factor between the disease states. Concurrent conditions such as depression, late-onset hypogonadism, Peyronie's disease and lower urinary tract symptoms may significantly worsen erectile function, other sexual and relationship issues and penis dysmorphophobia. A focused physical examination and baseline laboratory investigations are mandatory. Management consists of initiating modifiable lifestyle changes, psychological and psychosexual/couples interventions and pharmacological and other interventions. In combination and with treatment of Concurrent comorbid states, these interventions will often bring about successful resolution of symptoms and avoid the need for surgical interventions. Copyright (C) 2008 S. Karger AG, Basel.
C1 Nether Edge Hosp, Porterbrook Clin, Sheffield S11 9BF, S Yorkshire, England.
RP Wylie, K (corresponding author), Nether Edge Hosp, Porterbrook Clin, 75 Osborne Rd, Sheffield S11 9BF, S Yorkshire, England.
EM k.r.wylie@sheffield.ac.uk
RI Wylie, Kevan/C-5751-2011; Cristian, PhD, Professor Habil
   Delcea/AAC-1098-2020
OI Wylie, Kevan/0000-0003-3805-105X; Cristian, PhD, Professor Habil
   Delcea/0000-0003-0667-2898
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NR 87
TC 11
Z9 12
U1 1
U2 13
PU KARGER
PI BASEL
PA POSTFACH, CH-4009 BASEL, SWITZERLAND
SN 0065-3268
EI 1662-2855
BN 978-3-8055-8357-2
J9 ADV PSYCHOSOM MED
JI Adv.Psychosom.Med.
PY 2008
VL 29
BP 33
EP 49
DI 10.1159/000126623
PG 17
WC Clinical Neurology; Psychiatry
WE Book Citation Index – Science (BKCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Psychiatry
GA BHZ89
UT WOS:000257855200004
PM 18391556
DA 2025-06-11
ER

PT J
AU Tesauro, M
   Schinzari, F
   Adamo, A
   Rovella, V
   Martini, F
   Mores, N
   Barini, A
   Pitocco, D
   Ghirlanda, G
   Lauro, D
   Campia, U
   Cardillo, C
AF Tesauro, Manfredi
   Schinzari, Francesca
   Adamo, Angelo
   Rovella, Valentina
   Martini, Francesca
   Mores, Nadia
   Barini, Angela
   Pitocco, Dario
   Ghirlanda, Giovanni
   Lauro, Davide
   Campia, Umberto
   Cardillo, Carmine
TI Effects of GLP-1 on Forearm Vasodilator Function and Glucose Disposal
   During Hyperinsulinemia in the Metabolic Syndrome
SO DIABETES CARE
LA English
DT Article
ID GLUCAGON-LIKE PEPTIDE-1; ZUCKER OBESE RATS; INSULIN-RESISTANCE;
   ENDOTHELIAL FUNCTION; VASCULAR REACTIVITY; DYSFUNCTION; ARTERIES;
   PREVENTS; HUMANS; ATP
AB OBJECTIVE-Patients with the metabolic syndrome (MetS) have impaired insulin-induced enhancement of vasodilator responses. The incretin hormone glucagon-like peptide 1 (GLP-1), beyond its effects on blood glucose, has beneficial actions on vascular function. This study, therefore, aimed to assess whether GLP-1 affects insulin-stimulated vasodilator reactivity in patients with the MetS.
   RESEARCH DESIGN AND METHODS-Forearm blood flow responses to acetylcholine (ACh) and sodium nitroprusside (SNP) were assessed in MetS patients before and after the addition of GLP-1 to an intra-arterial infusion of saline (n = 5) or insulin (n = 5). The possible involvement of oxidative stress in the vascular effects of GLP-1 in this setting was investigated by infusion of vitamin C (n = 5). The receptor specificity of GLP-1 effect during hyperinsulinemia was assessed by infusing its metabolite GLP-1(9-36) (n = 5). The metabolic actions of GLP-1 were also tested by analyzing forearm glucose disposal during hyperinsulinemia (n = 5).
   RESULTS-In MetS patients, GLP-1 enhanced endothelium-dependent and -independent responses to ACh and SNP, respectively, during hyperinsulinemia (P < 0.001 for both), but not during saline (P> 0.05 for both). No changes in vasodilator reactivity to ACh and SNP were seen after GLP-1 was added to insulin and vitamin C (P> 0.05 for both) and after GLP-1(9-36) was given during hyperinsulinemia (P > 0.05 for both). Also, GLP-1 did not affect forearm glucose extraction and uptake during hyperinsulinemia (P > 0.05 for both).
   CONCLUSIONS-In patients with the MetS, GLP-1 improves insulin-mediated enhancement of endothelium-dependent and -independent vascular reactivity. This effect may be influenced by vascular oxidative stress and is possibly exerted through a receptor-mediated mechanism. Diabetes Care 36:683-689, 2013
C1 [Tesauro, Manfredi; Rovella, Valentina; Lauro, Davide] Univ Roma Tor Vergata, Dept Internal Med, Rome, Italy.
   [Schinzari, Francesca; Adamo, Angelo; Martini, Francesca; Pitocco, Dario; Ghirlanda, Giovanni; Cardillo, Carmine] Catholic Univ Med Sch, Dept Internal Med, Rome, Italy.
   [Mores, Nadia] Catholic Univ Med Sch, Dept Pharmacol, Rome, Italy.
   [Barini, Angela] Catholic Univ Med Sch, Dept Biochem, Rome, Italy.
   [Campia, Umberto] Northwestern Univ, Div Cardiol, Feinberg Sch Med, Chicago, IL 60611 USA.
C3 University of Rome Tor Vergata; Catholic University of the Sacred Heart;
   Catholic University of the Sacred Heart; Catholic University of the
   Sacred Heart; Northwestern University; Feinberg School of Medicine
RP Cardillo, C (corresponding author), Catholic Univ Med Sch, Dept Internal Med, Rome, Italy.
EM carmine.cardillo@rm.unicatt.it
RI schinzari, francesca/AAB-9982-2019; Pitocco, Dario/K-4210-2018; Rovella,
   Valentina/AAB-9727-2019
OI Rovella, Valentina/0000-0002-3311-486X; Cardillo,
   Carmine/0000-0001-5182-3005; MORES, Nadia/0000-0002-4197-0914; Lauro,
   Davide/0000-0002-8597-4415; Pitocco, Dario/0000-0002-6220-686X
FU Merck Sharp Dohme; Fondazione Roma; National Heart, Lung, and Blood
   Institute, National Institutes of Health [K12-HL083790]; Universita
   Cattolica del Sacro Cuore
FX This work was supported by a grant from Merck Sharp & Dohme and the
   Fondazione Roma to M.T. U.C. is supported by National Heart, Lung, and
   Blood Institute, National Institutes of Health, Grant K12-HL083790. C.C.
   is supported by Fondi d'Ateneo grants from Universita Cattolica del
   Sacro Cuore. No other potential conflicts of interest relevant to this
   article were reported.
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NR 28
TC 46
Z9 52
U1 0
U2 12
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0149-5992
EI 1935-5548
J9 DIABETES CARE
JI Diabetes Care
PD MAR
PY 2013
VL 36
IS 3
BP 683
EP 689
DI 10.2337/dc12-0763
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 103OU
UT WOS:000315928700041
PM 23069838
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Li, R
   Wang, WQ
   Zhang, H
   Yang, X
   Fan, Q
   Christopher, TA
   Lopez, BL
   Tao, L
   Goldstein, BJ
   Gao, F
   Ma, XL
AF Li, Rong
   Wang, Wen-Qing
   Zhang, Haifeng
   Yang, Xinchung
   Fan, Qian
   Christopher, Theodore A.
   Lopez, Bernard L.
   Tao, Ling
   Goldstein, Barry J.
   Gao, Feng
   Ma, Xin L.
TI Adiponectin improves endothelial function in hyperlipidemic rats by
   reducing oxidative/nitrative stress and differential regulation of
   eNOS/iNOS activity
SO AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
LA English
DT Article
DE metabolic syndrome; endothelial dysfunction; cytokine; nitric oxide;
   endothelial nitric oxide synthase; inducible nitric oxide synthase
ID NITRIC-OXIDE; HYPOADIPONECTINEMIA; DYSFUNCTION; ASSOCIATION; GLUCOSE; NO
AB Plasma adiponectin level is significantly reduced in patients with metabolic syndrome, and vascular dysfunction is an important pathological event in these patients. However, whether adiponectin may protect endothelial cells and attenuate endothelial dysfunction caused by metabolic disorders remains largely unknown. Adult rats were fed with a regular or a high-fat diet for 14 wk. The aorta was isolated, and vascular segments were incubated with vehicle or the globular domain of adiponectin ( gAd; 2 mu g/ ml) for 4 h. The effect of gAd on endothelial function, nitric oxide ( NO) and superoxide production, nitrotyrosine formation, gp91(phox) expression, and endothelial nitric oxide synthase (eNOS)/inducible NOS ( iNOS) activity/expression was determined. Severe endothelial dysfunction ( maximal vasorelaxation in response to ACh: 70.3 +/- 3.3 vs. 95.2 +/- 2.5% in control, P < 0.01) was observed in hyperlipidemic aortic segments, and treatment with gAd significantly improved endothelial function ( P < 0.01). Paradoxically, total NO production was significantly increased in hyperlipidemic vessels, and treatment with gAd slightly reduced, rather than increased, total NO production in these vessels. Treatment with gAd reduced (-78%, P < 0.01) superoxide production and peroxynitrite formation in hyperlipidemic vascular segments. Moreover, a moderate attenuation (-30%, P < 0.05) in gp91(phox) and iNOS overexpression in hyperlipidemic vessels was observed after gAd incubation. Treatment with gAd had no effect on eNOS expression but significantly increased eNOS phosphorylation ( P < 0.01). Most noticeably, treatment with gAd significantly enhanced eNOS (+83%) but reduced iNOS (-70%, P < 0.01) activity in hyperlipidemic vessels. Collectively, these results demonstrated that adiponectin protects the endothelium against hyperlipidemic injury by multiple mechanisms, including promoting eNOS activity, inhibiting iNOS activity, preserving bioactive NO, and attenuating oxidative/nitrative stress.
C1 Thomas Jefferson Univ Hosp, Dept Emergency Med, Philadelphia, PA 19107 USA.
   Chao Yang Hosp, Dept Cardiol, Beijing, Peoples R China.
   Thomas Jefferson Univ, Dept Emergency Med, Philadelphia, PA 19107 USA.
   Thomas Jefferson Univ, Dept Med, Philadelphia, PA 19107 USA.
   Fourth Mil Med Univ, Dept Physiol, Xian, Peoples R China.
C3 Thomas Jefferson University; Thomas Jefferson University; Thomas
   Jefferson University; Air Force Medical University
RP Ma, XL (corresponding author), Thomas Jefferson Univ Hosp, Dept Emergency Med, 1020 Sansom St, Thompson Bldg, Philadelphia, PA 19107 USA.
EM Xin.Ma@Jefferson.edu
RI Gao, Feng/X-4385-2019
OI Gao, Feng/0000-0001-6555-1717; Zhang, Haifeng/0000-0003-1938-3796
FU NHLBI NIH HHS [2R01-HL-63828] Funding Source: Medline
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NR 26
TC 151
Z9 165
U1 0
U2 9
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0193-1849
EI 1522-1555
J9 AM J PHYSIOL-ENDOC M
JI Am. J. Physiol.-Endocrinol. Metab.
PD DEC
PY 2007
VL 293
IS 6
BP E1703
EP E1708
DI 10.1152/ajpendo.00462.2007
PG 6
WC Endocrinology & Metabolism; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Physiology
GA 239HU
UT WOS:000251510200028
PM 17895290
DA 2025-06-11
ER

PT J
AU Takeshita, S
   Toda, H
   Tanaka, T
   Koga, M
   Yoshino, A
   Sawamura, T
AF Takeshita, Shogo
   Toda, Hiroyuki
   Tanaka, Teppei
   Koga, Minori
   Yoshino, Aihide
   Sawamura, Takehito
TI Psychological and physical condition of Japan maritime self-defense
   force personnel who performed disaster-relief missions after the 2011
   great east Japan earthquake
SO JOURNAL OF PSYCHIATRIC RESEARCH
LA English
DT Article
DE Disasters; Military personnel; Relief work; Surveys and questionnaires;
   Trauma- and stressor-related disorders
ID POSTTRAUMATIC-STRESS-DISORDER; ALCOHOL-USE; METABOLIC SYNDROME;
   VETERANS; DEPRESSION; PTSD; TRAUMA; ASSOCIATIONS; PREVALENCE; OUTCOMES
AB The Great East Japan Earthquake, which occurred on March 11, 2011, was the most powerful earthquake ever recorded in Japan. In the present study, we examine personnel from the Japan Maritime Self-Defense Force who performed disaster relief in the earthquake's aftermath, focusing on the associated psychological and physical impacts. Overall, 8733 personnel were examined. In both July-August 2011 (M1) and July 2012 (M2), these personnel answered the Impact of Events Scale-Revised, the Kessler Psychological Distress Scale, and the Disaster Relief Questionnaire. We also analyzed the sample's physical examination records for the periods before and after the earthquake, using as controls a sample of peers who were not dispatched to the disaster area (N = 32,270). The psychological examinations showed that, in M1, holding the rank of private/sergeant (odds ratio [OR] = 2.13), performing body-recovery duties (OR = 1.94), and having disaster-affected family members (OR = 2.13) were significant risk factors for high post-traumatic stress response (PTSR). In M2, performing bodyrecovery duties (OR = 1.45) and having disaster-affected family members (OR = 2.60) were significant risk factors for high PTSR. Also, being woman (OR = 2.18) and having disaster-affected family members (OR = 1.68) were significant risk factors for high general psychological distress. For the physical examinations, the mean alanine transaminase in the dispatched group (31.73 +/- 25.21) was significantly higher than that in the nondispatched group (29.56 +/- 21.03). These findings suggest that personnel involved in disaster relief experience psychological impacts in the subacute stage, but that these impacts attenuate one year after the event.
C1 [Takeshita, Shogo; Toda, Hiroyuki; Koga, Minori; Yoshino, Aihide] Natl Def Med Coll, Sch Med, Dept Psychiat, 3-2 Namiki, Tokorozawa, Saitama 3598513, Japan.
   [Tanaka, Teppei] Self Def Forces Yokosuka Hosp, Dept Psychiat, Yokosuka, Kanagawa, Japan.
   [Sawamura, Takehito] Self Def Forces Cent Hosp, Setagaya Ku, Tokyo, Japan.
   [Sawamura, Takehito] Maritime Staff Off, Med Planning Off, Shinjuku Ku, Tokyo, Japan.
C3 National Defense Medical College - Japan
RP Toda, H (corresponding author), Natl Def Med Coll, Sch Med, Dept Psychiat, 3-2 Namiki, Tokorozawa, Saitama 3598513, Japan.
EM toda1973@ndmc.ac.jp
RI Toda, Hiroyuki/IZQ-4881-2023
OI Toda, Hiroyuki/0000-0002-9736-4411
FU Promoted Research Program of Defense Medicine from the Ministry of
   Defense
FX This study was funded in part by a grant-in-aid from the Promoted
   Research Program of Defense Medicine from the Ministry of Defense. The
   Ministry had no part in the study design or any other aspect of the
   research project.
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NR 55
TC 2
Z9 4
U1 0
U2 3
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-3956
EI 1879-1379
J9 J PSYCHIATR RES
JI J. Psychiatr. Res.
PD NOV
PY 2020
VL 130
BP 104
EP 111
DI 10.1016/j.jpsychires.2020.07.023
PG 8
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA OC5DT
UT WOS:000579177600017
PM 32805519
DA 2025-06-11
ER

PT J
AU Goodwill, AG
   James, ME
   Frisbee, JC
AF Goodwill, Adam G.
   James, Milinda E.
   Frisbee, Jefferson C.
TI Increased vascular thromboxane generation impairs dilation of skeletal
   muscle arterioles of obese Zucker rats with reduced oxygen tension
SO AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
LA English
DT Article
DE skeletal muscle microcirculation; endothelium-dependent dilation;
   vascular reactivity; rodent models of obesity
ID INSULIN-RESISTANCE; METABOLIC SYNDROME; FUNCTIONAL VASODILATION;
   DYSFUNCTION; RISK; FLOW; VASOCONSTRICTION; PROSTAGLANDINS; INHIBITION;
   NITRATION
AB This study determined if altered vascular prostacyclin (PGI(2)) and/or thromboxane A(2) (TxA(2)) production with reduced PO2 contributes to impaired hypoxic dilation of skeletal muscle resistance arterioles of obese Zucker rats (OZRs) versus lean Zucker rats (LZRs). Mechanical responses were assessed in isolated gracilis muscle arterioles following reductions in PO2 under control conditions and following pharmacological interventions inhibiting arachidonic acid metabolism and nitric oxide synthase and alleviating elevated vascular oxidant stress. The production of arachidonic acid metabolites was assessed using pooled arteries from OZRs and LZRs in response to reduced PO2. Hypoxic dilation, endothelium-dependent in both strains, was attenuated in OZRs versus LZRs. Nitric oxide synthase inhibition had no significant impact on hypoxic dilation in either strain. Cyclooxygenase inhibition dramatically reduced hypoxic dilation in LZRs and abolished responses in OZRs. Treatment of arterioles from OZRs with polyethylene glycol-superoxide dismutase improved hypoxic dilation, and this improvement was entirely cyclooxygenase dependent. Vascular PGI(2) production with reduced PO2 was similar between strains, although TxA(2) production was increased in OZRs, a difference that was attenuated by treatment of vessels from OZRs with polyethylene glycol-superoxide dismutase. Both blockade of PGH(2)/TxA(2) receptors and inhibition of thromboxane synthase increased hypoxic dilation in OZR arterioles. These results suggest that a contributing mechanism underlying impaired hypoxic dilation of skeletal muscle arterioles of OZRs may be an increased vascular production of TxA(2), which competes against the vasodilator influences of PGI(2). These results also suggest that the elevated vascular oxidant stress inherent in metabolic syndrome may contribute to the increased vascular TxA(2) production and may blunt vascular sensitivity to PGI(2).
C1 W Virginia Univ, Ctr Interdisciplinary Res Cardiovasc Sci, Dept Physiol & Pharmacol, Robert C Byrd Hlth Sci Ctr,Sch Med, Morgantown, WV 26505 USA.
C3 West Virginia University
RP Frisbee, JC (corresponding author), W Virginia Univ, Ctr Interdisciplinary Res Cardiovasc Sci, Dept Physiol & Pharmacol, Robert C Byrd Hlth Sci Ctr,Sch Med, POB 9105, Morgantown, WV 26505 USA.
EM jfrisbee@hsc.wvu.edu
RI Goodwill, Adam/N-4889-2016
OI Goodwill, Adam/0000-0003-3701-3713; Frisbee,
   Jefferson/0000-0003-2751-0599
FU American Heart Association [SDG 0330194N]; National Institute of
   Diabetes and Digestive and Kidney Diseases [R01-DK-64668]
FX The authors gratefully acknowledge the support provided through the
   "Translational Research Initiative: Cardiorespiratory Health in
   Appalachia From Mechanisms to Policy" at the West Virginia University
   Health Sciences Center in the performance of this study. This study was
   supported by American Heart Association Grant SDG 0330194N and National
   Institute of Diabetes and Digestive and Kidney Diseases Grant
   R01-DK-64668.
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NR 34
TC 33
Z9 40
U1 0
U2 0
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0363-6135
EI 1522-1539
J9 AM J PHYSIOL-HEART C
JI Am. J. Physiol.-Heart Circul. Physiol.
PD OCT
PY 2008
VL 295
IS 4
BP H1522
EP H1528
DI 10.1152/ajpheart.00596.2008
PG 7
WC Cardiac & Cardiovascular Systems; Physiology; Peripheral Vascular
   Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Physiology
GA 357PB
UT WOS:000259857500019
PM 18689495
OA Green Published
DA 2025-06-11
ER

PT J
AU Hitomi, H
   Kiyomoto, H
   Nishiyama, A
   Hara, T
   Moriwaki, K
   Kaifu, K
   Ihara, G
   Fujita, Y
   Ugawa, T
   Kohno, M
AF Hitomi, Hirofumi
   Kiyomoto, Hideyasu
   Nishiyama, Akira
   Hara, Taiga
   Moriwaki, Kumiko
   Kaifu, Kumiko
   Ihara, Genei
   Fujita, Yoshiko
   Ugawa, Toyomu
   Kohno, Masakazu
TI Aldosterone suppresses insulin signaling via the downregulation of
   insulin receptor substrate-1 in vascular smooth muscle cells
SO HYPERTENSION
LA English
DT Article; Proceedings Paper
CT 17th Scientific Meeting of the Inter-American-Society-of-Hypertension
CY MAY 06-10, 2007
CL Miami Beach, FL
SP Inter Amer Soc Hypertens
DE aldosterone; oxidative stress; insulin receptor substrate-1; insulin
   resistance; type 2 diabetes mellitus; metabolic syndrome; eplerenone
ID ANGIOTENSIN-II; NADPH OXIDASE; METABOLIC SYNDROME; MECHANISMS;
   RESISTANCE; HYPERTENSION; KINASE; EPLERENONE; ACTIVATION; DISEASE
AB Clinical reports indicate that patients with primary aldosteronism commonly have impaired glucose tolerance; however, the relationship between aldosterone and insulin signaling pathway has not been clarified. In this study, we examined the effects of aldosterone treatment on insulin receptor substrate-1 expression and insulin signaling pathway including Akt phosphorylation and glucose uptake in rat vascular smooth muscle cells. Insulin receptor substrate-1 protein expression and Akt phosphorylation were determined by Western blot analysis with anti-insulin receptor substrate-1 and phosphorylated-Akt antibodies, respectively. Glucose metabolism was evaluated using 3H-labeled 2-deoxy-D-glucose uptake. Aldosterone (1-100 nmol/L) dose-dependently decreased insulin receptor substrate-1 protein expression with a peak at 18 hours (n = 4). Aldosterone-induced degradation of insulin receptor substrate-1 was markedly attenuated by treatment with the selective mineralocorticoid receptor antagonist eplerenone (10 mu mol/L; n = 4). Furthermore, degradation was blocked by the Src inhibitor PP1 (20 mu mol/L; n = 4). Treatment with antioxidants, N-acetylcysteine (10 mmol/L), or ebselen (40 mu mol/L) also attenuated aldosterone-induced insulin receptor substrate-1 degradation (n = 4). In addition, proteasome inhibitor MG132 (1 mu mol/L) prevented insulin receptor substrate-1 degradation (n = 4). Aldosterone treatment abolished insulin-induced Akt phosphorylation (100 nmol/L; 5 minutes; n = 4). Furthermore, aldosterone pretreatment decreased insulin-stimulated (100 nmol/L; 60 minutes; n = 4) glucose uptake by 50%, which was reversed by eplerenone (10 mu mol/L; n = 4). These data indicate that aldosterone decreases insulin receptor substrate-1 expression via Src and reactive oxygen species stimulation by proteasome-dependent degradation in vascular smooth muscle cells; thus, aldosterone may be involved in the pathogenesis of vascular insulin resistance via oxidative stress.
C1 Kagawa Univ, Dept Cardiorenal & Cerebrovasc Med, Fac Med, Miki, Kagawa 7610793, Japan.
   Kagawa Univ, Dept Pharmacol, Fac Med, Miki, Kagawa 7610793, Japan.
C3 Kagawa University; Kagawa University
RP Hitomi, H (corresponding author), Kagawa Univ, Dept Cardiorenal & Cerebrovasc Med, Fac Med, 1750-1 Ikenobe, Miki, Kagawa 7610793, Japan.
EM hitomi@kms.ac.jp
RI Hitomi, Hirofumi/ABA-2086-2021
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NR 35
TC 120
Z9 129
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0194-911X
EI 1524-4563
J9 HYPERTENSION
JI Hypertension
PD OCT
PY 2007
VL 50
IS 4
BP 750
EP 755
DI 10.1161/HYPERTENSIONAHA.107.093955
PG 6
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Cardiovascular System & Cardiology
GA 212HN
UT WOS:000249586900027
PM 17646573
OA Bronze
DA 2025-06-11
ER

PT J
AU Pieczynska, K
   Rzymski, P
AF Pieczynska, Katarzyna
   Rzymski, Piotr
TI Health Benefits of Vegetarian and Mediterranean Diets: Narrative Review
SO POLISH JOURNAL OF FOOD AND NUTRITION SCIENCES
LA English
DT Review
DE human diet; plant-based diets; clinical trials; meta-analysis; human
   health
ID CARDIOVASCULAR-DISEASE; BLOOD-PRESSURE; CANCER INCIDENCE; RISK-FACTORS;
   METAANALYSIS; ADHERENCE; MEAT; INFLAMMATION; OMNIVORES; PATTERN
AB Diet is an important lifestyle factor influencing disease risk. Vegetarian and Mediterranean diets have their proponents and are promoted for various potential health benefits. Over the years, numerous cross-sectional and cohort studies and randomized clinical trials have been conducted to elucidate the relationship between the Mediterranean and vegetarian diet and cardiovascular, cancer, diabetes, and other disease risks. More recently, research has been conducted to compare both diets directly. In this narrative review, we discuss the effects of vegetarian and Mediterranean diets on lipid profile, blood pressure, inflammation markers, body weight, risk of cardiovascular disease, cancer, diabetes mellitus, metabolic syndrome, and chronic kidney disease, as well as their associations with gut microbiota and mental health. The paper also discusses the studies comparing vegetarian and Mediterranean diets and their health effects. It provides further evidence that both diets can be beneficial and advocates their promotion, especially in Westernized populations plagued by various chronic lifestyle-associated diseases. At the same time, the Mediterranean dietary model may appear to be a superior public health strategy, less prone to the risk of nutritional deficiencies and less challenging in implantation on a broader scale. However, further studies based on cross-over design and long-term observations are recommended to thoroughly compare vegetarian and Mediterranean diets and draw more firm conclusions on their effects on health.
C1 [Pieczynska, Katarzyna; Rzymski, Piotr] Poznan Univ Med Sci, Dept Environm Med, Rokietnicka Str 8, PL-60806 Poznan, Poland.
   [Rzymski, Piotr] USERN, ISA, Rokietnicka Str 8, PL-60806 Poznan, Poland.
C3 Poznan University of Medical Sciences
RP Rzymski, P (corresponding author), Poznan Univ Med Sci, Dept Environm Med, Rokietnicka Str 8, PL-60806 Poznan, Poland.; Rzymski, P (corresponding author), USERN, ISA, Rokietnicka Str 8, PL-60806 Poznan, Poland.
EM rzymskipiotr@ump.edu.pl
RI Rzymski, Piotr/I-2240-2012
OI Rzymski, Piotr/0000-0002-4713-0801
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NR 140
TC 4
Z9 4
U1 7
U2 25
PU INST ANIMAL REPRODUCTION & FOOD RESEARCH POLISH ACAD SCIENCES OLSZTYN
PI OLSZTYN
PA UL J TUWIMA 10, OLSZTYN, 10-747, POLAND
SN 1230-0322
EI 2083-6007
J9 POL J FOOD NUTR SCI
JI Pol. J. food Nutr. Sci.
PY 2022
VL 72
IS 4
BP 327
EP 346
DI 10.31883/pjfns/156067
PG 20
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA 6Y4QD
UT WOS:000897080300001
OA gold
DA 2025-06-11
ER

PT J
AU Mullor, D
   Cangas, AJ
   Gallego, J
   Aguilar-Parra, JM
   Rosado, A
   López, A
AF Mullor, David
   Cangas, Adolfo J.
   Gallego, Jose
   Aguilar-Parra, Jose M.
   Rosado, Antonio
   Lopez, Andres
TI A longitudinal study about the impact of an inclusive sports program in
   people with a diagnosis of schizophrenia
SO PSYCHOSIS-PSYCHOLOGICAL SOCIAL AND INTEGRATIVE APPROACHES
LA English
DT Article
DE Schizophrenia; physical activity; sports; mental health; physical
   health; inclusion
ID MAJOR DEPRESSIVE DISORDER; WEIGHT-LOSS INTERVENTION; PHYSICAL-ACTIVITY;
   MENTAL-ILLNESS; SEDENTARY BEHAVIOR; METABOLIC SYNDROME; BIPOLAR
   DISORDER; HEALTH; EXERCISE; METAANALYSIS
AB The present study analyzes the impact of an Inclusive Sports and Physical Activity Program which lasted 14 months on a sample of people with a diagnosis schizophrenia. 30 people took part in the study. An initial evaluation was conducted after 7 months and a final evaluation was carried out at the end of the program. In addition, a follow-up evaluation was conducted 1 year after the program had ended. The sample was divided into two groups based on attendance (those who participated regularly, and those who attended occasionally). Results showed statistically significant improvements in the functional aerobic capacity of both groups, but to a greater degree for the individuals who attended regularly. In terms of body composition, statistically significant improvements were only observed among the group with regular attendance. Regarding motor skills, only balance was improved (in both groups). A general decline in the physical variables assessed was observed in the follow-up, however, this decline was less pronounced among the group of individuals that attended the program regularly than for the group with lower attendance. The results confirm the effectiveness of this type of intervention, particularly when carried out regularly, and show the need to promote inclusive programs in people with a diagnosis of schizophrenia that favor adherence to these types of programs.
C1 [Mullor, David; Cangas, Adolfo J.; Gallego, Jose; Aguilar-Parra, Jose M.] Univ Almeria, Dept Psychol, Almeria, Spain.
   [Rosado, Antonio] Univ Lisbom, Fac Motricidade Humana, Lisbon, Portugal.
   [Lopez, Andres] Andalusian Publ Fdn Social Integrat People Mental, Seville, Spain.
C3 Universidad de Almeria; Universidade de Lisboa
RP Cangas, AJ (corresponding author), Univ Almeria, Dept Psychol, Almeria, Spain.
EM ajcangas@ual.es
RI Mullor Ponce, David/IAO-2194-2023; Gallego, José/AAT-4645-2021; Rosado,
   Antonio/J-1642-2012; AGUILAR PARRA, JOSE MANUEL/AAD-6978-2019; Cangas,
   Adolfo J./A-5497-2009; Rosado, Antonio/E-4909-2019
OI Cangas, Adolfo J./0000-0002-5646-5582; Rosado,
   Antonio/0000-0003-2336-0853; Lopez Pardo, Andres
   Maria/0000-0001-9696-8398
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NR 31
TC 4
Z9 4
U1 2
U2 23
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 1752-2439
EI 1752-2447
J9 PSYCHOSIS
JI Psychosis
PD JAN 2
PY 2019
VL 11
IS 1
BP 75
EP 84
DI 10.1080/17522439.2018.1559873
PG 10
WC Psychology, Clinical; Psychiatry
WE Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA HP4LN
UT WOS:000461647600008
OA hybrid
DA 2025-06-11
ER

PT J
AU Jaulmes, A
   Sansilvestri-Morel, P
   Rolland-Valognes, G
   Bernhardt, F
   Gaertner, R
   Lockhart, BP
   Cordi, A
   Wierzbicki, M
   Rupin, A
   Verbeuren, TJ
AF Jaulmes, Amandine
   Sansilvestri-Morel, Patricia
   Rolland-Valognes, Gaelle
   Bernhardt, Fabienne
   Gaertner, Roger
   Lockhart, Brian P.
   Cordi, Alex
   Wierzbicki, Michel
   Rupin, Alain
   Verbeuren, Tony J.
TI Nox4 mediates the expression of plasminogen activator inhibitor-1 via
   p38 MAPK pathway in cultured human endothelial cells
SO THROMBOSIS RESEARCH
LA English
DT Article
DE Endothelial cells; MAPK; NADPH oxidase; Nox4; PAI-1; siRNA
ID PAI-1 GENE-EXPRESSION; NECROSIS-FACTOR-ALPHA; REACTIVE OXYGEN; NAD(P)H
   OXIDASE; NADPH OXIDASE; OXIDATIVE STRESS; METABOLIC SYNDROME;
   PATHOPHYSIOLOGY; ATHEROSCLEROSIS; DYSFUNCTION
AB Introduction: Plasminogen Activator Inhibitor-1 (PAI-1) is the most potent endogenous inhibitor of fibrinolysis which is implicated in the pathogenesis of myocardial infarction and metabolic syndrome. The formation of reactive oxygen species (ROS) plays an important role in the pathology of vascular disorders and has been shown to increase PAI-1 expression by endothelial cells. Growing evidence indicates that NADPH oxidase and in particular the constitutively active Nox4-p22(phox) complexes are major sources of ROS in endothelial cells. The aim of the present study was to characterize the role of NADPH oxidase and in particular Nox4 in the regulation of PAI-1 expression in cultured Human Umbilical Venous Endothelial Cells (HUVECs).
   Methods and Results: N-acetylcysteine (NAC, scavenger of ROS), diphenylene iodonium chloride (DPI, inhibitor of flavoproteins), M40403 (superoxyde dismutase mimic) and S 17834 (inhibitor of NADPH oxidase) inhibited PAI-1 release and promoter activity in HUVECs. Specific knock down of Nox4 mRNA by si RNA caused a decrease in ROS production and NADPH oxidase activity. Moreover, Nox4 silencing decreased PAI-1 expression, release and activity as well as p38 MAPK pathways and NF kappa B activation. These signalling pathways are also involved in PAI-1 release.
   Conclusions: The NADPH oxidase inhibitors DPI and S 17834 as well as Nox4 silencing decreased PAI-1 synthesis in human cultured endothelial cells demonstrating the involvement of the constitutively active Nox4-containing NADPH oxidase in ROS-mediated PAI-1 transcription via p38 MAPK pathways. NADPH oxidase targeting with inhibitors such as S17834 could be an interesting strategy to decrease both oxidative stress and PAI-1 synthesis. (C) 2009 Elsevier Ltd. All rights reserved.
C1 [Jaulmes, Amandine; Sansilvestri-Morel, Patricia; Bernhardt, Fabienne; Gaertner, Roger; Rupin, Alain; Verbeuren, Tony J.] Servier Res Inst, Div Angiol, F-92150 Suresnes, France.
   [Cordi, Alex; Wierzbicki, Michel] Servier Res Inst, Div Chem, F-92150 Suresnes, France.
   [Rolland-Valognes, Gaelle; Lockhart, Brian P.] Servier Res Inst, Div Mol Pharmacol & Physiopathol, F-78290 Croissy Sur Seine, France.
C3 Servier; Institut de Recherches Internationales Servier; Servier;
   Institut de Recherches Internationales Servier; Servier; Institut de
   Recherches Internationales Servier
RP Verbeuren, TJ (corresponding author), Servier Res Inst, Div Angiol, 11 Rue Moulineaux, F-92150 Suresnes, France.
EM tony.verbeuren@fr.netgrs.com
OI Gaertner, Roger Frederic/0009-0006-9956-3197; Sansilvestri-Morel,
   Patricia/0000-0003-3685-4473
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NR 38
TC 46
Z9 53
U1 1
U2 4
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0049-3848
J9 THROMB RES
JI Thromb. Res.
PD AUG-SEP
PY 2009
VL 124
IS 4
BP 439
EP 446
DI 10.1016/j.thromres.2009.05.018
PG 8
WC Hematology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Hematology; Cardiovascular System & Cardiology
GA 499TR
UT WOS:000270249300011
PM 19540572
DA 2025-06-11
ER

PT J
AU Kurita, S
   Takamura, T
   Ota, T
   Matsuzawa-Nagata, N
   Kita, Y
   Uno, M
   Nabemoto, S
   Ishikura, K
   Misu, H
   Ando, H
   Zen, Y
   Nakanuma, Y
   Kaneko, S
AF Kurita, Seiichiro
   Takamura, Toshinari
   Ota, Tsuguhito
   Matsuzawa-Nagata, Naoto
   Kita, Yuki
   Uno, Masafumi
   Nabemoto, Satoko
   Ishikura, Kazuhide
   Misu, Hirofumi
   Ando, Hitoshi
   Zen, Yoh
   Nakanuma, Yasuni
   Kaneko, Shuichi
TI Olmesartan ameliorates a dietary rat model of non-alcoholic
   steatohepatitis through its pleiotropic effects
SO EUROPEAN JOURNAL OF PHARMACOLOGY
LA English
DT Article
DE angiotensin II type 1 receptor blocker; insulin resistance; NADPH
   oxidase; non-alcoholic steatohepatitis; oxidative stress;
   renin-angiotensin system
ID RENIN-ANGIOTENSIN SYSTEM; HEPATIC STELLATE CELLS; NECROSIS-FACTOR-ALPHA;
   FATTY LIVER-DISEASE; FRUCTOSE-FED RATS; INSULIN-RESISTANCE; NADPH
   OXIDASE; RECEPTOR ANTAGONIST; LIPID-PEROXIDATION; METABOLIC SYNDROME
AB Insulin resistance is a major pathological condition associated with obesity and metabolic syndrome. Insulin resistance and the renin-angiotensin system are intimately linked. We evaluated the role of the renin-angiotensin system in the pathogenesis of insulin resistance-associated, non-alcoholic steatohepatitis by using the angiotensin II type 1 receptor blocker olmesartan medoxomil in a diabetic rat model. The effects of olmesartan on methionine- and choline-deficient (MCD) diet-induced steatohepatitis were investigated in obese, diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) rats and control Long-Evans Tokushima Otsuka (LETO) rats. Components of the renin-angiotensin system were up-regulated in the livers of OLETF rats, compared with LETO rats. In OLETF, but not LETO, rats, oral administration of olmesartan for 8 weeks ameliorated insulin resistance. Moreover, olmesartan suppressed MCD diet-induced hepatic steatosis and the hepatic expression of lipogenic genes (sterol regulatory element-binding protein-1c and fatty acid synthase) in OLETF, but not LETO, rats. In both OLETF and LETO rats, olmesartan inhibited hepatic oxidative stress (4-hydroxy-2-nonenal-modified protein) and expression of NADPH oxidase. Olmesartan also inhibited hepatic fibrosis, stellate cell activation, and expression of fibrogenic genes (transforming growth factor-beta, alpha 1 [I] procollagen, plasminogen activator inhibitor-1) in both OLETF and LETO rats. In conclusion, pharmacological blockade of the angiotensin II type 1 receptor slows the development of steatohepatitis in the OLETF rat model. This angiotensin II type 1 receptor blocker may exert insulin resistance-associated effects against hepatic steatosis and inflammation as well as direct effects against the generation of reactive oxygen species and fibrogenesis. (C) 2008 Elsevier B.V. All rights reserved.
C1 [Kurita, Seiichiro; Takamura, Toshinari; Ota, Tsuguhito; Matsuzawa-Nagata, Naoto; Kita, Yuki; Uno, Masafumi; Nabemoto, Satoko; Ishikura, Kazuhide; Misu, Hirofumi; Ando, Hitoshi; Kaneko, Shuichi] Kanazawa Univ, Grad Sch Med Sci, Dept Dis Control & Homeostasis, Kanazawa, Ishikawa 9208641, Japan.
   [Zen, Yoh; Nakanuma, Yasuni] Kanazawa Univ, Grad Sch Med Sci, Dept Human Pathol, Kanazawa, Ishikawa 9208641, Japan.
C3 Kanazawa University; Kanazawa University
RP Takamura, T (corresponding author), Kanazawa Univ, Grad Sch Med Sci, Dept Dis Control & Homeostasis, 13-1 Takara Machi, Kanazawa, Ishikawa 9208641, Japan.
EM ttakamura@m-kanazawa.jp
RI ANDO, Hitoshi/O-8199-2016; Nagata, Naoto/D-9261-2012
OI Nagata, Naoto/0000-0002-2389-2334
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NR 49
TC 33
Z9 38
U1 0
U2 1
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0014-2999
J9 EUR J PHARMACOL
JI Eur. J. Pharmacol.
PD JUL 7
PY 2008
VL 588
IS 2-3
BP 316
EP 324
DI 10.1016/j.ejphar.2008.04.028
PG 9
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 319TS
UT WOS:000257187600026
PM 18501344
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Keating, CL
   Peeters, A
   Swinburn, BA
   Magliano, DJ
   Moodie, ML
AF Keating, Catherine L.
   Peeters, Anna
   Swinburn, Boyd A.
   Magliano, Dianna J.
   Moodie, Marjory L.
TI Utility-Based Quality of Life Associated with Overweight and Obesity:
   The Australian Diabetes, Obesity, and Lifestyle Study
SO OBESITY
LA English
DT Article
ID HEALTH; INDEX; WEIGHT; EQ-5D
AB Objective: This study aimed to estimate utility-based quality of life (UQoL) differences between healthy body weight and excess body weight categories.
   Design and Methods: Cross-sectional analysis of 10,959 adults, participating in baseline data collection of the nationally representative Australian Diabetes, Obesity, and Lifestyle (AusDiab) Study was undertaken. Height and weight were measured by trained personnel. Body weight categories were assigned as healthy weight, overweight, and obesity subclasses I, II and III. UQoL was assessed using the SF-6D, which captures physical functioning, role limitation, social functioning, pain, mental health, and vitality on a score of 0.00-1.00 (worst-best). The relationship between body weight categories and UQoL was assessed using linear regression, adjusting for age, sex, education, and smoking.
   Results: Relative to the healthy weight group (mean UQoL score 0.77), mean adjusted UQoL differences (95% confidence intervals) were 0.001 (-0.008, 0.010) for overweight, -0.012 (-0.022, -0.001) for class-I obese, -0.020 (-0.041, 0.001) for class-II obese, and -0.069 (-0.099, -0.039) for class- III obese groups. Adding metabolic syndrome markers to the covariates had little impact on these differences.
   Conclusion: Results confirmed an inverse dose-response relationship between body weight and UQoL in this study of Australian adults. This highlights the need to incorporate UQoL measures which are sensitive to the subclasses of obesity when evaluating obesity interventions.
C1 [Keating, Catherine L.; Moodie, Marjory L.] Deakin Univ, Deakin Hlth Econ, Melbourne, Vic, Australia.
   [Peeters, Anna; Magliano, Dianna J.] Monash Univ, Dept Epidemiol & Preventat Med, Melbourne, Vic 3004, Australia.
   [Peeters, Anna; Magliano, Dianna J.] Baker IDI Heart & Diabet Inst, Melbourne, Vic, Australia.
   [Swinburn, Boyd A.] Deakin Univ, World Hlth Org Collaborating Ctr Obes Prevent, Melbourne, Vic, Australia.
C3 Deakin University; Monash University; Baker Heart and Diabetes
   Institute; World Health Organization; World Health Organization (WHO)
   Australia; Deakin University
RP Keating, CL (corresponding author), Deakin Univ, Deakin Hlth Econ, Melbourne, Vic, Australia.
EM catherine.keating@deakin.edu.au
RI Swinburn, Boyd/JXL-3452-2024; Peeters, Anna/M-8284-2019
OI Magliano, Dianna/0000-0002-9507-6096; Moodie,
   Marjory/0000-0001-6890-5250; Magliano, Dianna
   Josephine/0000-0002-6026-5065
FU VicHealth; National Health and Medical Research Council; Australia
   Research Council; Global Corporate Challenge; Victorian Cancer Agency
   Public Health Fellowship; NHMRC Capacity Building grant; Allergan
   Australia; Deakin University
FX A.P. is funded by VicHealth, National Health and Medical Research
   Council and Australia Research Council, and has also received research
   funds from the Global Corporate Challenge. D.J.M. is supported by a
   Victorian Cancer Agency Public Health Fellowship. M.L.M. is supported by
   a NHMRC Capacity Building grant. C.L.K., A.P., and M.L.M. received an
   independent research grant from Allergan Australia, which contributed to
   salary costs. B.A.S. was funded by Deakin University. We thank The
   Australian Diabetes, Obesity, and Lifestyle (AusDiab) Study for
   providing data upon request and review and coauthorship for this study.
   We thank John Brazier, Director of Sheffield Health Economics Group, The
   University of Sheffield, for providing a computer algorithm for deriving
   the preference-based utility index (SF-6D) from SF-36 data.
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NR 15
TC 30
Z9 30
U1 0
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1930-7381
EI 1930-739X
J9 OBESITY
JI Obesity
PD MAR
PY 2013
VL 21
IS 3
BP 652
EP 655
DI 10.1002/oby.20290
PG 4
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 187AK
UT WOS:000322087600058
PM 23592675
OA Green Submitted, Bronze
DA 2025-06-11
ER

PT J
AU Galli, M
   Hameed, A
   Zbikowski, A
   Zabielski, P
AF Galli, Mauro
   Hameed, Ahsan
   Zbikowski, Arkadiusz
   Zabielski, Piotr
TI Aquaporins in insulin resistance and diabetes: More than channels!
SO REDOX BIOLOGY
LA English
DT Article
DE Aquaporins; Obesity; Insulin resistance; Type-2 diabetes; Metabolic
   syndrome
ID HYDROGEN-PEROXIDE; ADIPOSE-TISSUE; GENE-EXPRESSION;
   HEPATOCELLULAR-CARCINOMA; COORDINATED REGULATION; GLYCEROL METABOLISM;
   MEMBRANE-TRANSPORT; SLEEVE GASTRECTOMY; CELL-MIGRATION; WATER CHANNEL
AB Aquaporins (AQPs) are part of the family of the integral membrane proteins. Their function is dedicated to the transport of water, glycerol, ammonia, urea, H2O2, and other small molecules across the biological membranes. Although for many years they were scarcely considered, AQPs have a relevant role in the development of many diseases. Recent discoveries suggest, that AQPs may play an important role in the process of fat accumulation and regulation of oxidative stress, two crucial aspects of insulin resistance and type-2 diabetes (T2D).
   Insulin resistance (IR) and T2D are multi-faceted systemic diseases with multiple connections to obesity and other comorbidities such as hypertension, dyslipidemia and metabolic syndrome. Both IR and T2D transcends different tissues and organs, creating the maze of mutual relationships between adipose fat depots, skeletal muscle, liver and other insulin-sensitive organs. AQPs with their heterogenous properties, distinctive tissue distribution and documented involvement in both the lipid metabolism and regulation of the oxidative stress appear to be feasible candidates in the search for the explanation to this third-millennium plague. A lot of research has been assigned to adipose tissue AQP7 and liver tissue AQP9, clarifying their relationship and co-ordinated work in the induction of hepatic insulin resistance. Novel research points also to other aquaporins, such as AQP11 which may be associated with the induction of insulin resistance and T2D through its involvement in hydrogen peroxide transport.
   In this review we collected recent discoveries in the field of AQP's involvement in the insulin resistance and T2D. Novel paths which connect AQPs with metabolic disorders can give new fuel to the research on obesity, insulin resistance and T2D - one of the most worrying problems of the modern society.
C1 [Galli, Mauro; Zbikowski, Arkadiusz; Zabielski, Piotr] Med Univ Bialystok, Dept Med Biol, PL-15089 Bialystok, Poland.
   [Hameed, Ahsan] Med Univ Bialystok, Clin Res Ctr, PL-15089 Bialystok, Poland.
C3 Medical University of Bialystok; Medical University of Bialystok
RP Zabielski, P (corresponding author), Med Univ Bialystok, Dept Med Biol, PL-15089 Bialystok, Poland.
EM mauro.galli@umb.edu.pl; ahsan.hameed@umb.edu.pl;
   arkadiusz.zbikowski@umb.edu.pl; piotr.zabielski@umb.edu.pl
RI Galli, Mauro/HCH-5669-2022; Hameed, Ahsan/V-1687-2019; Zabielski,
   Piotr/U-8363-2018
OI Zbikowski, Arkadiusz Franciszek/0000-0002-4276-053X; Zabielski,
   Piotr/0000-0002-4901-5217; Galli, Mauro/0000-0003-3871-8125; Hameed,
   Ahsan/0000-0002-9858-2525
FU European Union's Horizon 2020 research and innovation programme under
   the Marie SkodowskaCurie grant [754432]; Polish Ministry of Science and
   Higher Education; Medical University of Bialystok [SUB/1/DN/19/002/1117]
FX This research was conducted within the project which has received
   funding from the European Union's Horizon 2020 research and innovation
   programme under the Marie SkodowskaCurie grant agreement No 754432 and
   the Polish Ministry of Science and Higher Education, from financial
   resources for science in 2018-2023 granted for the implementation of an
   international cofinanced project. This research was supported by the
   Medical University of Bialystok [SUB/1/DN/19/002/1117] .
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NR 137
TC 36
Z9 36
U1 4
U2 17
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2213-2317
J9 REDOX BIOL
JI Redox Biol.
PD AUG
PY 2021
VL 44
AR 102027
DI 10.1016/j.redox.2021.102027
EA JUN 2021
PG 12
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA SU8YD
UT WOS:000663416300004
PM 34090243
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Bouabout, G
   Ayme-Dietrich, E
   Jacob, H
   Champy, MF
   Biding, MC
   Pavlovic, G
   Madeira, L
   Fertak, LE
   Petit-Demoulière, B
   Sorg, T
   Herault, Y
   Mudgett, J
   Monassier, L
AF Bouabout, Ghina
   Ayme-Dietrich, Estelle
   Jacob, Hugues
   Champy, Marie-France
   Biding, Marie-Christine
   Pavlovic, Guillaume
   Madeira, Lola
   Fertak, Lahcen Et
   Petit-Demouliere, Benoit
   Sorg, Tania
   Herault, Yann
   Mudgett, John
   Monassier, Laurent
TI Nox4 genetic inhibition in experimental hypertension and metabolic
   syndrome
SO ARCHIVES OF CARDIOVASCULAR DISEASES
LA English
DT Article
DE NADPH oxidase; Nox4; Hypertension; Angiotensin; Metabolism
ID NADPH OXIDASE ISOFORMS; OXIDATIVE STRESS; ANGIOTENSIN-II;
   BLOOD-PRESSURE; HYPERTROPHY; EXPRESSION; PROTECTS; FAMILY; OBESE
AB Background. - Metabolic syndrome is a combination of symptoms including obesity, dyslipidaemia, glucose intolerance and hypertension. Oxidative stress appears to be a pathophysiological factor that links these signs and encourages progression towards heart failure and diabetes. Nox4 is a hydrogen peroxide nicotinamide adenine dinucleotide phosphate (NADPH) oxidase isoform - found in various cardiovascular cells and tissues, but also in tissues such as the liver - which is involved in glucose and lipid homeostasis.
   Aims. - To test whether inhibition of the Nox4 enzyme could improve blood pressure and metabolic parameters in mice receiving either angiotensin II or a high-fat diet.
   Methods. - Systolic and diastolic arterial pressures, pulse rate and heart rate were obtained in 24 male mice (12 wild-type [WT] and 12 Nox4(-/-)) before and during 14 days of angiotensin II infusion. After angiotensin II infusion, cardiac histological remodeling was assessed. Weight and biochemical parameters were measured in 18 male and 18 female mice (nine WT and nine Nox4(-/-) per gender) after 10 weeks on a standard chow diet, then 15 weeks on a high-fat diet. Glucose tolerance and insulin sensitivity were tested at age 25 weeks.
   Results. - Knock-out animals did not demonstrate a baseline blood pressure phenotype, but blocking Nox4 protected against angiotensin II-mediated arterial and pulse pressure increases. No protection against angiotensin II-induced cardiac fibrosis was observed. From a metabolic point of view, Nox4 inhibition reduced plasma triglycerides in male and female mice under a chow diet. However, Nox4 deletion did not affect the metabolic profile under a high-fat diet in males or females, but increased glucose intolerance in females.
   Conclusion. - Our data identify Nox4 as a key source of radical oxygen species involved in hypertension and some metabolic problems. (C) 2017 Elsevier Masson SAS. All rights reserved.
C1 [Bouabout, Ghina; Jacob, Hugues; Champy, Marie-France; Biding, Marie-Christine; Pavlovic, Guillaume; Fertak, Lahcen Et; Petit-Demouliere, Benoit; Sorg, Tania; Herault, Yann; Monassier, Laurent] Univ Strasbourg, Inst Clin Souris, Inst Genet & Biol Mol & Cellulaire, Illkirch Graffenstaden, France.
   [Ayme-Dietrich, Estelle; Madeira, Lola; Monassier, Laurent] Univ Strasbourg, CHU Strasbourg, Fac Med, Lab Neurobiol & Pharmacol Cardiovasc,Federat Med, 11 Rue Humann, F-67085 Strasbourg, France.
   [Mudgett, John] Merck Res Labs, Kenilworth, NJ USA.
C3 Universites de Strasbourg Etablissements Associes; Universite de
   Strasbourg; Institut National de la Sante et de la Recherche Medicale
   (Inserm); Universites de Strasbourg Etablissements Associes; Universite
   de Strasbourg; CHU Strasbourg; Merck & Company
RP Monassier, L (corresponding author), Univ Strasbourg, CHU Strasbourg, Fac Med, Lab Neurobiol & Pharmacol Cardiovasc,Federat Med, 11 Rue Humann, F-67085 Strasbourg, France.
EM laurent.monassier@unistra.fr
RI AYME, Estelle/AAC-8392-2022; Monassier, Laurent/AAE-4446-2022; Pavlovic,
   Guillaume/C-9907-2013; Herault, Yann/B-5500-2012
OI Pavlovic, Guillaume/0000-0001-9122-4592; Birling,
   Marie-Christine/0000-0002-3372-8108; Monassier,
   Laurent/0000-0001-8341-4986; Sorg, Tania/0000-0001-6974-4735;
   Ayme-Dietrich, Estelle/0000-0002-0613-3803; Herault,
   Yann/0000-0001-7049-6900
FU Merck; ICS research and development
FX Merck and ICS research and development.
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NR 37
TC 21
Z9 23
U1 0
U2 9
PU ELSEVIER MASSON, CORPORATION OFFICE
PI PARIS
PA 65 CAMILLE DESMOULINS CS50083 ISSY-LES-MOULINEAUX, 92442 PARIS, FRANCE
SN 1875-2136
EI 1875-2128
J9 ARCH CARDIOVASC DIS
JI Arch. Cardiovasc. Dis.
PD JAN
PY 2018
VL 111
IS 1
BP 41
EP 52
DI 10.1016/j.acvd.2017.03.011
PG 12
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA FU7WV
UT WOS:000424064300006
PM 29113787
OA Bronze
DA 2025-06-11
ER

PT J
AU Guéant, JL
   Elakoum, R
   Ziegler, O
   Coelho, D
   Feigerlova, E
   Daval, JL
   Guéant-Rodriguez, RM
AF Gueant, Jean-Louis
   Elakoum, Rania
   Ziegler, Olivier
   Coelho, David
   Feigerlova, Eva
   Daval, Jean-Luc
   Gueant-Rodriguez, Rosa-Maria
TI Nutritional models of foetal programming and nutrigenomic and epigenomic
   dysregulations of fatty acid metabolism in the liver and heart
SO PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
LA English
DT Article
DE Foetal programming; Metabolic syndrome; High-fat diet; Protein
   restriction; Folate; Vitamin B-12; Epigenomics
ID METHYL DONOR DEFICIENCY; ACTIVATED RECEPTOR-ALPHA; PROTEIN-RESTRICTED
   DIET; ALTERED EPIGENETIC REGULATION; TERM CALORIC RESTRICTION; DNA
   METHYLATION; INSULIN-RESISTANCE; GENE-EXPRESSION; CONTRACTILE
   DYSFUNCTION; MATERNAL NUTRITION
AB Barker's concept of 'foetal programming' proposes that intrauterine growth restriction (IUGR) predicts complex metabolic diseases through relationships that may be further modified by the postnatal environment. Dietary restriction and deficit in methyl donors, folate, vitamin B-12, and choline are used as experimental conditions of foetal programming as they lead to IUGR and decreased birth weight. Overfeeding and deficit in methyl donors increase central fat mass and lead to a dramatic increase of plasma free fatty acids (FFA) in offspring. Conversely, supplementing the mothers under protein restriction with folic acid reverses metabolic and epigenomic phenotypes of offspring. High-fat diet or methyl donor deficiency (MDD) during pregnancy and lactation produce liver steatosis and myocardium hypertrophy that result from increased import of FFA and impaired fatty acid beta-oxidation, respectively. The underlying molecular mechanisms show dysregulations related with similar decreased expression and activity of sirtuin 1 (SIRT1) and hyperacetylation of peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha). High-fat diet and overfeeding impair AMPK-dependent phosphorylation of PGC-1 alpha, while MDD decreases PGC-1 alpha methylation through decreased expression of PRMT1 and cellular level of S-adenosyl methionine. The visceral manifestations of metabolic syndrome are under the influence of endoplasmic reticulum (ER) stress in overnourished animal models. These mechanisms should also deserve attention in the foetal programming effects of MDD since vitamin B-12 influences ER stress through impaired SIRT1 deacetylation of HSF1. Taken together, similarities and synergies of high-fat diet and MDD suggest, therefore, considering their consecutive or contemporary influence in the mechanisms of complex metabolic diseases.
C1 [Gueant, Jean-Louis; Elakoum, Rania; Ziegler, Olivier; Coelho, David; Feigerlova, Eva; Daval, Jean-Luc; Gueant-Rodriguez, Rosa-Maria] Univ Lorraine, INSERM, Nutr Genet Environm Risk Exposure N GERE, U954, F-54511 Vandoeuvre Les Nancy, France.
   [Gueant, Jean-Louis; Elakoum, Rania; Ziegler, Olivier; Coelho, David; Feigerlova, Eva; Daval, Jean-Luc; Gueant-Rodriguez, Rosa-Maria] Univ Hosp Ctr Nancy, F-54511 Vandoeuvre Les Nancy, France.
C3 Universite de Lorraine; Institut National de la Sante et de la Recherche
   Medicale (Inserm); CHU de Nancy
RP Guéant, JL (corresponding author), Univ Lorraine, INSERM, Nutr Genet Environm Risk Exposure N GERE, U954, BP 184, F-54511 Vandoeuvre Les Nancy, France.
EM jean-louis.gueant@univ-lorraine.fr
RI Guéant-Rodriguez, Rosa-Maria/ABK-8588-2022; Daval, Jean-Luc/G-6502-2014;
   Coelho, David/F-6680-2011
OI Coelho, David/0000-0001-7010-5789
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NR 187
TC 43
Z9 46
U1 0
U2 49
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0031-6768
EI 1432-2013
J9 PFLUG ARCH EUR J PHY
JI Pflugers Arch.
PD MAY
PY 2014
VL 466
IS 5
BP 833
EP 850
DI 10.1007/s00424-013-1339-4
PG 18
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA AG7DH
UT WOS:000335577700001
PM 23999818
DA 2025-06-11
ER

PT J
AU Björntorp, P
   Rosmond, R
AF Björntorp, P
   Rosmond, R
TI Neuroendocrine abnormalities in visceral obesity
SO INTERNATIONAL JOURNAL OF OBESITY
LA English
DT Article; Proceedings Paper
CT 8th International Congress on Endocrinology of Obesity Basic, Clinical
   and Therapeutic Aspects
CY SEP, 1998
CL VENICE, ITALY
DE neuroendocrine; endocrine; stress; obesity; Metabolic Syndrome
ID BODY-FAT DISTRIBUTION; PITUITARY-ADRENAL AXIS;
   FRAGMENT-LENGTH-POLYMORPHISM; ADIPOSE-TISSUE DISTRIBUTION; CORTISOL
   SECRETION; SALIVARY CORTISOL; BLOOD-PRESSURE; MEN BORN; WOMEN; INSULIN
AB Central obesity is the subfraction which carries most of the risks for comorbidities. In this overview we suggest that this is due to neuroendocrine perturbations, where the hypothalamic-pituitary-adrenal [HPA) axis assumes a central role. The HPA axis is stimulated by central factors, which are often called stress. This is followed by discrete, periodical elevations of cortisol secretion during every day conditions. Such observations require diurnal measurements under undisturbed conditions. Saliva cortisol is useful for such purposes.
   It seems likely, based on cross-sectional observations in men and longitudinal studies in animals that a prolonged period of HPA axis stimulation is followed by a continuous degradation of the regulatory mechanisms. An end stage is a rigid cortisol secretion with low morning values. In parallel with this is a diminished function of the feed-back control as well as an inhibition of growth and sex steroid hormones. Evidence also suggests that the sympathetic nervous centers become activated in parallel.
   The net effects of this cascade of neuroendocrine-endocrine pertubations will be insulin resistance as well as visceral accumulation of body fat. These are effects of cortisol in combination with the diminished secretion of growth and sex steroid secretions, which in normal concentrations antagonize the cortisol effects. Blood pressure will also be elevated, which might be a consequence of central stimulation of the sympathetic nervous system, with added effects of insulin. What has developed is a hypothalamic arousal with the Metabolic Syndrome as a consequence.
   The feed-back regulation of the HPA axis has a key position in this chain of events. This control is mediated via glucocorticoid receptors in the lower parts of the brain. The gene for this receptor has shown polymorphisms which are associated with poorly regulated cortisol secretion, centeral obesity, insulin resistance and hypertension.
C1 Univ Gothenburg, Sahlgrens Hosp, Dept Heart & Lung Dis, Gothenburg, Sweden.
   Louisiana State Univ, Pennington Biomed Res Ctr, Baton Rouge, LA USA.
C3 Sahlgrenska University Hospital; University of Gothenburg; Louisiana
   State University System; Louisiana State University; Pennington
   Biomedical Research Center
RP Univ Gothenburg, Sahlgrens Hosp, Dept Heart & Lung Dis, Gothenburg, Sweden.
EM Per.Bjorntorp@Hjl.gu.se
CR [Anonymous], ACTA MED SCAND S
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NR 37
TC 188
Z9 221
U1 0
U2 8
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0307-0565
EI 1476-5497
J9 INT J OBESITY
JI Int. J. Obes.
PD JUN
PY 2000
VL 24
SU 2
BP S80
EP S85
DI 10.1038/sj.ijo.0801285
PG 6
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 335NW
UT WOS:000088250400019
PM 10997616
DA 2025-06-11
ER

PT J
AU Hasan, SS
   Ahmadi, K
   Santigo, R
   Ahmed, SI
AF Hasan, S. S.
   Ahmadi, K.
   Santigo, R.
   Ahmed, S. I.
TI The validity of the Menopause-specific Quality of Life questionnaire in
   women with type 2 diabetes
SO CLIMACTERIC
LA English
DT Article
DE VALIDITY; MENOPAUSE; QUALITY OF LIFE; DIABETES
ID POSTMENOPAUSAL WOMEN; METABOLIC SYNDROME; RISK-FACTORS; POPULATION;
   MORTALITY; MELLITUS; DEPRESSION; COUNTRIES; YEAR-2000; SYMPTOMS
AB Objectives To examine the validity and reliability of the Menopause-specific Quality of Life (MENQOL) questionnaire in a sample of women with diabetes in Malaysia, with the secondary aim of determining whether MENQOL domain scores were associated with depression and diabetes.
   Methods A total of 337 postmenopausal women (241 with diabetes, 96 controls) were evaluated. Construct validity was evaluated using principal components analysis (PCA) and comparing scale items against the mental component score of the Short Form-12 (SF-12 MCS), and against the Center for Epidemiologic Studies Depression Scale 10 (CES-D 10). Consistency assessment was conducted using Cronbach's alpha.
   Results The internal consistencies for the physical (PHS), psychosocial (PS), sexual (VSS) and vasomotor domains were 0.86, 0.79, 0.79 and 0.70, and 0.90 for the full scale of MENQOL. PCA revealed a four-factorial model. Diabetes and non-diabetes subjects experienced their first period (13.25 vs. 13.10 years, p = 0.680) and achieved menopause around the same age (49.35 vs. 48.87 years, p = 0.426). We found significant variations in the MENQOI's PHS and PS domain scores that could be explained by SF-12 PCS (25%) and SF-12 MCS (20%) sub-scales. The validity of the MENQOL domains was demonstrated through significant associations with the equivalent SF-12 MCS and PCS subscales. The PS domain of the MENQOL also predicted the likelihood of symptoms of depression (1.42, 95% confidence interval 1.01-2.02).
   Conclusions This study confirms the validity and internal consistency of the MENQOL questionnaire for measuring quality of life in postmenopausal women with diabetes, suggesting that the instrument can be used to screen people for menopausal symptoms.
C1 [Hasan, S. S.] Univ Queensland, Woolloongabba, Qld 4102, Australia.
   [Ahmadi, K.; Santigo, R.; Ahmed, S. I.] Int Med Univ, Kuala Lumpur 57000, Malaysia.
C3 University of Queensland; International Medical University Malaysia
RP Hasan, SS (corresponding author), Univ Queensland, 20 Cornwall St, Woolloongabba, Qld 4102, Australia.
EM shahzad.syed@uqconnect.edu.au
RI Hasan, Syed Shahzad/V-9082-2018; Ahmadi, Keivan/AAU-5419-2020; Ahmed,
   Syed Imran/Q-7217-2016
OI Ahmed, Syed Imran/0000-0001-7134-807X; Hasan, Syed
   Shahzad/0000-0002-4058-2215; Armani, Keivan/0000-0001-5674-2765
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NR 43
TC 10
Z9 10
U1 0
U2 11
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 1369-7137
EI 1473-0804
J9 CLIMACTERIC
JI Climacteric
PD AUG
PY 2014
VL 17
IS 4
BP 456
EP 464
DI 10.3109/13697137.2013.864269
PG 9
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Obstetrics & Gynecology
GA AM2RQ
UT WOS:000339698900020
PM 24228772
DA 2025-06-11
ER

PT J
AU Setji, TL
   Brown, AJ
AF Setji, Tracy L.
   Brown, Ann J.
TI Polycystic Ovary Syndrome: Update on Diagnosis and Treatment
SO AMERICAN JOURNAL OF MEDICINE
LA English
DT Review
DE Hirsutism; Insulin resistance; Irregular menses; Oligomenorrhea; PCOS;
   Polycystic ovary syndrome; Treatment
ID CLINICAL-PRACTICE GUIDELINE; PLACEBO-CONTROLLED TRIAL; FATTY
   LIVER-DISEASE; GLUCOSE-TOLERANCE; ANDROGEN EXCESS; DOUBLE-BLIND; WOMEN;
   PREVALENCE; RISK; HIRSUTISM
AB Polycystic ovary syndrome is now a well-recognized condition affecting 6%-25% of reproductive-aged women, depending on the definition. Over the past 3 decades, research has launched it from relative medical obscurity to a condition increasingly recognized as common in internal medicine practices. It affects multiple systems, and requires a comprehensive perspective on health care for effective treatment. Metabolic derangements and associated complications include insulin resistance and diabetes, hyperlipidemia, hypertension, fatty liver, metabolic syndrome, and sleep apnea. Reproductive complications include oligo-/amenorrhea, sub-fertility, endometrial hyperplasia, and cancer. Associated psychosocial concerns include depression and disordered eating. Additionally, cosmetic issues include hirsutism, androgenic alopecia, and acne. This review organizes this multi-system approach around the mnemonic "MY PCOS" and discusses evaluation and treatment options for the reproductive, cosmetic, and metabolic complications of this condition. (C) 2014 Elsevier Inc. All rights reserved.
C1 [Setji, Tracy L.; Brown, Ann J.] Duke Univ, Med Ctr, Dept Med, Div Endocrinol, Durham, NC 27710 USA.
C3 Duke University
RP Setji, TL (corresponding author), Duke Univ, Med Ctr, 201 Trent Dr,Box 3222, Durham, NC 27710 USA.
EM tracy.setji@duke.edu
CR [Anonymous], 2012, NIH EV BAS METH WORK
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NR 41
TC 73
Z9 81
U1 0
U2 50
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0002-9343
EI 1555-7162
J9 AM J MED
JI Am. J. Med.
PD OCT
PY 2014
VL 127
IS 10
BP 912
EP 919
DI 10.1016/j.amjmed.2014.04.017
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA AR0GO
UT WOS:000343249200021
PM 24859638
DA 2025-06-11
ER

PT J
AU Tsai, CY
   Hsieh, SC
   Lu, CS
   Wu, TH
   Liao, HT
   Wu, CH
   Li, KJ
   Kuo, YM
   Lee, HT
   Shen, CY
   Yu, CL
AF Tsai, Chang-Youh
   Hsieh, Song-Chou
   Lu, Cheng-Shiun
   Wu, Tsai-Hung
   Liao, Hsien-Tzung
   Wu, Cheng-Han
   Li, Ko-Jen
   Kuo, Yu-Min
   Lee, Hui-Ting
   Shen, Chieh-Yu
   Yu, Chia-Li
TI Cross-Talk between Mitochondrial Dysfunction-Provoked Oxidative Stress
   and Aberrant Noncoding RNA Expression in the Pathogenesis and
   Pathophysiology of SLE
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE noncoding RNA; microRNA; long noncoding RNA; mitochondrial dysfunction;
   oxidative stress; nitrosative stress. exosome; cross-talk; systemic
   lupus erythematosus
ID SYSTEMIC-LUPUS-ERYTHEMATOSUS; CELL FATE DECISION; T-CELLS;
   N-ACETYLCYSTEINE; DNA METHYLATION; CHIP-CHIP; ER STRESS; MICRORNAS;
   DISEASE; INFLAMMATION
AB Systemic lupus erythematosus (SLE) is a prototype of systemic autoimmune disease involving almost every organ. Polygenic predisposition and complicated epigenetic regulations are the upstream factors to elicit its development. Mitochondrial dysfunction-provoked oxidative stress may also play a crucial role in it. Classical epigenetic regulations of gene expression may include DNA methylation/acetylation and histone modification. Recent investigations have revealed that intracellular and extracellular (exosomal) noncoding RNAs (ncRNAs), including microRNAs (miRs), and long noncoding RNAs (lncRNAs), are the key molecules for post-transcriptional regulation of messenger (m)RNA expression. Oxidative and nitrosative stresses originating from mitochondrial dysfunctions could become the pathological biosignatures for increased cell apoptosis/necrosis, nonhyperglycemic metabolic syndrome, multiple neoantigen formation, and immune dysregulation in patients with SLE. Recently, many authors noted that the cross-talk between oxidative stress and ncRNAs can trigger and perpetuate autoimmune reactions in patients with SLE. Intracellular interactions between miR and lncRNAs as well as extracellular exosomal ncRNA communication to and fro between remote cells/tissues via plasma or other body fluids also occur in the body. The urinary exosomal ncRNAs can now represent biosignatures for lupus nephritis. Herein, we'll briefly review and discuss the cross-talk between excessive oxidative/nitrosative stress induced by mitochondrial dysfunction in tissues/cells and ncRNAs, as well as the prospect of antioxidant therapy in patients with SLE.
C1 [Tsai, Chang-Youh; Liao, Hsien-Tzung] Taipei Vet Gen Hosp, Div Allergy Immunol & Rheumatol, 201 Sec 2,Shih Pai Rd, Taipei 11217, Taiwan.
   [Tsai, Chang-Youh; Wu, Tsai-Hung; Liao, Hsien-Tzung] Natl Yang Ming Univ, 201 Sec 2,Shih Pai Rd, Taipei 11217, Taiwan.
   [Hsieh, Song-Chou; Lu, Cheng-Shiun; Wu, Cheng-Han; Li, Ko-Jen; Kuo, Yu-Min; Shen, Chieh-Yu; Yu, Chia-Li] Natl Taiwan Univ Hosp, Dept Internal Med, 7 Chung Shan South Rd, Taipei 10002, Taiwan.
   [Lu, Cheng-Shiun; Wu, Cheng-Han; Kuo, Yu-Min; Shen, Chieh-Yu] Natl Taiwan Univ, Inst Clin Med, Coll Med, 7 Chung Shan South Rd, Taipei 10002, Taiwan.
   [Wu, Tsai-Hung] Taipei Vet Gen Hosp, Div Nephrol, 201 Sec 2,Shih Pai Rd, Taipei 11217, Taiwan.
   [Lee, Hui-Ting] Mackay Mem Hosp, Sect Allergy Immunol & Rheumatol, 92 Sec 2,Chung Shan North Rd, Taipei 10449, Taiwan.
C3 Taipei Veterans General Hospital; National Yang Ming Chiao Tung
   University; National Taiwan University; National Taiwan University
   Hospital; National Taiwan University; Taipei Veterans General Hospital;
   Mackay Memorial Hospital
RP Tsai, CY (corresponding author), Taipei Vet Gen Hosp, Div Allergy Immunol & Rheumatol, 201 Sec 2,Shih Pai Rd, Taipei 11217, Taiwan.; Tsai, CY (corresponding author), Natl Yang Ming Univ, 201 Sec 2,Shih Pai Rd, Taipei 11217, Taiwan.; Yu, CL (corresponding author), Natl Taiwan Univ Hosp, Dept Internal Med, 7 Chung Shan South Rd, Taipei 10002, Taiwan.
EM cytsai@vghtpe.gov.tw; hsiehsc@ntu.edu.tw; b89401085@ntu.edu.tw;
   thwu@vghtpe.gov.tw; darryliao@yahoo.com.tw; chenghanwu@ntu.edu.tw;
   dtmed170@yahoo.com.tw; 543goole@gmail.com; htlee1228@gmail.com;
   tsichhl@gmail.com; chialiyu0717@gmail.com
RI Shen, Chiehyu/JVE-1092-2024; Tsai, Chang-Youh/IZD-5962-2023; Tsai,
   Chang-Youh/G-1747-2013
OI Shen, Chieh-Yu/0000-0002-3218-0689; Tsai,
   Chang-Youh/0000-0002-4154-4018; LI, KO-JEN/0000-0002-4544-4620;
   /0000-0002-4794-9438
FU Ministry of Science & Technology, Executive Yuan
   [MOST107-2314B075-051-MY3, MOST106-2634-F-075-001]; Taipei Veterans
   General Hospital, Taiwan [V107D37-002-MY3]
FX This research was funded by Ministry of Science & Technology, Executive
   Yuan, (MOST107-2314B075-051-MY3, and MOST106-2634-F-075-001) and Taipei
   Veterans General Hospital (V107D37-002-MY3), Taiwan.
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NR 136
TC 29
Z9 30
U1 0
U2 8
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD OCT 2
PY 2019
VL 20
IS 20
AR 5183
DI 10.3390/ijms20205183
PG 18
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA JQ3AZ
UT WOS:000498822800215
PM 31635056
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Stener-Victorin, E
   Jedel, E
   Manneras, L
AF Stener-Victorin, E.
   Jedel, E.
   Manneras, L.
TI Acupuncture in polycystic ovary syndrome: Current experimental and
   clinical evidence
SO JOURNAL OF NEUROENDOCRINOLOGY
LA English
DT Review
DE acupuncture; insulin resistance; metabolic syndrome; obesity; opioids;
   ovulation; physical exercise; polycystic ovary syndrome; sympathetic
   nerve activity
ID NERVE GROWTH-FACTOR; P75 NEUROTROPHIN RECEPTORS; LIFE-STYLE
   MODIFICATION; BLOOD-FLOW RESPONSES; BETA-ENDORPHIN; ELECTROACUPUNCTURE
   STIMULATION; SYMPATHETIC ACTIVATION; PLACEBO NEEDLE; SERUM LEPTIN;
   LH-SECRETION
AB This review describes the aetiology and pathogenesis of polycystic ovary syndrome (PCOS) and evaluates the use of acupuncture to prevent and reduce symptoms related with PCOS. PCOS is the most common female endocrine disorder and it is strongly associated with hyperandrogenism, ovulatory dysfunction and obesity. PCOS increases the risk for metabolic disturbances such as hyperinsulinaemia and insulin resistance, which can lead to type 2 diabetes, hypertension and an increased likelihood of developing cardiovascular risk factors and impaired mental health later in life. Despite extensive research, little is known about the aetiology of PCOS. The syndrome is associated with peripheral and central factors that influence sympathetic nerve activity. Thus, the sympathetic nervous system may be an important factor in the development and maintenance of PCOS. Many women with PCOS require prolonged treatment. Current pharmacological approaches are effective but have adverse effects. Therefore, nonpharmacological treatment strategies need to be evaluated. Clearly, acupuncture can affect PCOS via modulation of endogenous regulatory systems, including the sympathetic nervous system, the endocrine and the neuroendocrine system. Experimental observations in rat models of steroid-induced polycystic ovaries and clinical data from studies in women with PCOS suggest that acupuncture exert long-lasting beneficial effects on metabolic and endocrine systems and ovulation.
C1 [Stener-Victorin, E.; Manneras, L.] Univ Gothenburg, Sahlgrenska Acad, Dept Physiol Endocrinol, Inst Neurosci & Physiol, SE-40530 Gothenburg, Sweden.
   [Jedel, E.] Karolinska Inst, Dept Clin Neurosci, Osher Ctr Integrat Med, Stockholm, Sweden.
C3 University of Gothenburg; Karolinska Institutet
RP Stener-Victorin, E (corresponding author), Univ Gothenburg, Sahlgrenska Acad, Dept Physiol Endocrinol, Inst Neurosci & Physiol, Box 434, SE-40530 Gothenburg, Sweden.
EM elisabet.stener-victorin@neuro.gu.se
RI Jedel, Elizabeth/ABE-7420-2020; Stener-Victorin, Elisabet/W-6322-2018
OI Stener-Victorin, Elisabet/0000-0002-3424-1502; Manneras Holm,
   Louise/0000-0001-8783-6107
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NR 96
TC 71
Z9 91
U1 1
U2 48
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0953-8194
EI 1365-2826
J9 J NEUROENDOCRINOL
JI J. Neuroendocrinol.
PD MAR
PY 2008
VL 20
IS 3
BP 290
EP 298
DI 10.1111/j.1365-2826.2007.01634.x
PG 9
WC Endocrinology & Metabolism; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology
GA 267AF
UT WOS:000253479500002
PM 18047551
DA 2025-06-11
ER

PT J
AU Ogiso, K
   Shayo, SC
   Kawade, S
   Hashiguchi, H
   Deguchi, T
   Nishio, Y
AF Ogiso, Kazuma
   Shayo, Sigfrid Casmir
   Kawade, Shigeru
   Hashiguchi, Hiroshi
   Deguchi, Takahisa
   Nishio, Yoshihiko
TI Repeated glucose spikes and insulin resistance synergistically
   deteriorate endothelial function and bardoxolone methyl ameliorates
   endothelial dysfunction
SO PLOS ONE
LA English
DT Article
ID PROTEIN-KINASE-C; OXIDATIVE STRESS; MITOCHONDRIAL SUPEROXIDE;
   CARDIOVASCULAR-DISEASE; DEPENDENT RELAXATION; VASCULAR DYSFUNCTION;
   POTENTIAL TARGET; CELLS; ATHEROSCLEROSIS; ACTIVATION
AB Background
   Both insulin resistance and postprandial glucose spikes are known for their potential to induce vascular endothelial dysfunction in individuals with metabolic syndrome. However, these factors are inextricable, and therefore, their relative contributions to inducing endothelial dysfunction remain elusive. In this study, we aimed to disentangle the effects of these factors and clarify whether bardoxolone methyl (CDDO-Me), a novel nuclear factor erythroid 2-related factor 2 (Nrf2) activator, protects against glucose spike-induced endothelial dysfunction.
   Methods
   We induced glucose spikes twice daily for a duration of 1 week to rats fed a standard/control diet (CD) and Western-type diet (WTD). Endothelium-dependent relaxation (EDR) was evaluated using isolated thoracic aortas. Gene expression and dihydroethidium (DHE)-fluorescence studies were carried out; the effect of CDDO-Me on aortic endothelial dysfunction in vivo was also evaluated.
   Results
   Neither WTD-induced insulin resistance nor pure glucose spikes significantly deteriorated EDR. However, under high-glucose (20 mM) conditions, the EDR of thoracic aortas of WTD-fed rats subjected to glucose spikes was significantly impaired. In this group of rats, we observed significantly enhanced DHE fluorescence as a marker of reactive oxygen species, upregulation of an oxidative stress-related gene (NOX2), and downregulation of an antioxidant gene (SOD2) in the thoracic aortas. As expected, treatment of the thoracic aorta of this group of rats with antioxidant agents significantly improved EDR. We also noted that pretreatment of aortas from the same group with CDDO-Me attenuated endothelial dysfunction, accompanied by a correction of the redox imbalance, as observed in gene expression and DHE fluorescence studies.
   Conclusions
   For the first time, we showed that insulin resistance and glucose spikes exert a synergistic effect on aortic endothelial dysfunction. Furthermore, our study reveals that CDDO-Me ameliorates endothelial dysfunction caused by glucose spikes in a rat model of metabolic syndrome.
C1 [Ogiso, Kazuma; Shayo, Sigfrid Casmir; Kawade, Shigeru; Hashiguchi, Hiroshi; Deguchi, Takahisa; Nishio, Yoshihiko] Kagoshima Univ, Dept Diabet & Endocrine Med, Grad Sch Med & Dent Sci, Kagoshima, Japan.
C3 Kagoshima University
RP Nishio, Y (corresponding author), Kagoshima Univ, Dept Diabet & Endocrine Med, Grad Sch Med & Dent Sci, Kagoshima, Japan.
EM ynishio@m3.kufm.kagoshima-u.ac.jp
OI SHAYO, SIGFRID/0000-0003-4090-8809
FU Japan Society for the Promotion of Science (JSPS) KAKENHI [20K08890];
   Grants-in-Aid for Scientific Research [20K08890] Funding Source: KAKEN
FX This research was supported by Japan Society for the Promotion of
   Science (JSPS) KAKENHI grant number 20K08890. Y. Nishio received this
   grant. URL: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K08890/The
   funders had no role in study design, data collection and analysis,
   decision to publish, or preparation of the manuscript.
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NR 68
TC 9
Z9 10
U1 0
U2 5
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JAN 24
PY 2022
VL 17
IS 1
AR e0263080
DI 10.1371/journal.pone.0263080
PG 26
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA ZZ4EH
UT WOS:000773223800064
PM 35073378
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Nikolic, I
   Leiva, M
   Sabio, G
AF Nikolic, Ivana
   Leiva, Magdalena
   Sabio, Guadalupe
TI The role of stress kinases in metabolic disease
SO NATURE REVIEWS ENDOCRINOLOGY
LA English
DT Review
ID ACTIVATED PROTEIN-KINASE; INDUCED INSULIN-RESISTANCE;
   ENDOPLASMIC-RETICULUM STRESS; NECROSIS-FACTOR-ALPHA; ADIPOSE-TISSUE
   INFLAMMATION; P38 MAP KINASES; SKELETAL-MUSCLE; TNF-ALPHA;
   SIGNAL-TRANSDUCTION; ENERGY HOMEOSTASIS
AB Obesity activates stress-activated protein kinases (SAPKs), such as the p38 and JNK stress kinases, in several tissues, including adipose, liver, skeletal muscle, immune organs and the central nervous system. This Review discusses the role of SAPKs in metabolic control and highlights important discoveries in the field.
   Obesity is a health condition that has reached pandemic levels and is implicated in the development and progression of type 2 diabetes mellitus, cancer and heart failure. A key characteristic of obesity is the activation of stress-activated protein kinases (SAPKs), such as the p38 and JNK stress kinases, in several organs, including adipose tissue, liver, skeletal muscle, immune organs and the central nervous system. The correct timing, intensity and duration of SAPK activation contributes to cellular metabolic adaptation. By contrast, uncontrolled SAPK activation has been proposed to contribute to the complications of obesity. The stress kinase signalling pathways have therefore been identified as potential targets for the development of novel therapeutic approaches for metabolic syndrome. The past few decades have seen intense research efforts to determine how these kinases are regulated in a cell-specific manner and to define their contribution to the development of obesity and insulin resistance. Several studies have uncovered new and unexpected functions of the non-classical members of both pathways. Here, we provide an overview of the role of SAPKs in metabolic control and highlight important discoveries in the field.
C1 [Nikolic, Ivana; Leiva, Magdalena; Sabio, Guadalupe] Ctr Nacl Invest Cardiovasc CNIC, Madrid, Spain.
C3 Centro Nacional de Investigaciones Cardiovasculares (CNIC)
RP Sabio, G (corresponding author), Ctr Nacl Invest Cardiovasc CNIC, Madrid, Spain.
EM guadalupe.sabio@cnic.es
RI Nikolic, Ivana/F-1435-2015; Sabio, Guadalupe/H-9733-2015
OI Nikolic, Ivana/0000-0003-2879-8563; Sabio, Guadalupe/0000-0002-2822-0625
FU EFSD/Lilly grant (2017); CNIC IPP FP7 Marie Curie Programme
   [PCOFUND-2012-600396]; EFSD Rising Star award (2019); MINECO
   [IJC2018-035390-I]; Spanish grant MINECO-FEDER [SAF2015-74112-JIN];
   Fundacion AECC [INVES20026LEIV, PROYE19047SABI]; European Union [ERC
   260464]; EFSD/Lilly European Diabetes Research Programme; BBVA
   Foundation Leonardo Grants program for Researchers and Cultural Creators
   (Investigadores-BBVA-2017) [IN[17]_BBM_BAS_0066]; MINECO-FEDER
   [SAF2016-79126-R, PID2019-104399RB-I00]; Comunidad de Madrid
   [IMMUNOTHERCAN-CM S2010/BMD-2326, B2017/BMD-3733]; Instituto de Salud
   Carlos III (ISCIII); Ministerio de Ciencia, Innovacion y Universidades
   (MCNU); Pro CNIC Foundation; Severo Ochoa Center of Excellence
   [SEV-2015-0505]; EFSD/Lilly grant (2019)
FX We thank S. Bartlett for English editing and C. Lopez-Otin for his
   helpful discussion and valuable comments. I.N. was funded by EFSD/Lilly
   grants (2017 and 2019), the CNIC IPP FP7 Marie Curie Programme
   (PCOFUND-2012-600396), an EFSD Rising Star award (2019) and grant MINECO
   IJC2018-035390-I. M.L. was supported by Spanish grant MINECO-FEDER
   SAF2015-74112-JIN and Fundacion AECC: INVES20026LEIV. G.S. received
   funding from the following programmes and organizations: European Union
   Seventh Framework Programme (FP7/2007-2013) under grant agreement number
   ERC 260464; EFSD/Lilly European Diabetes Research Programme; Fundacion
   AECC PROYE19047SABI; BBVA Foundation Leonardo Grants program for
   Researchers and Cultural Creators (Investigadores-BBVA-2017)
   IN[17]_BBM_BAS_0066; MINECO-FEDER SAF2016-79126-R and
   PID2019-104399RB-I00; and the Comunidad de Madrid (IMMUNOTHERCAN-CM
   S2010/BMD-2326 and B2017/BMD-3733). The CNIC is supported by the
   Instituto de Salud Carlos III (ISCIII), the Ministerio de Ciencia,
   Innovacion y Universidades (MCNU) and the Pro CNIC Foundation and is a
   Severo Ochoa Center of Excellence (SEV-2015-0505). We thank our
   collaborators and the students and fellows who contributed to the
   studies in the Sabio group over the years. We regret that we were unable
   to include citations to all other relevant studies owing to space
   constraints.
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NR 180
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Z9 62
U1 1
U2 22
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 1759-5029
EI 1759-5037
J9 NAT REV ENDOCRINOL
JI Nat. Rev. Endocrinol.
PD DEC
PY 2020
VL 16
IS 12
BP 697
EP 716
DI 10.1038/s41574-020-00418-5
EA OCT 2020
PG 20
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA OO1BM
UT WOS:000578402700002
PM 33067545
DA 2025-06-11
ER

PT J
AU Vogeli, C
   Shields, AE
   Lee, TA
   Gibson, TB
   Marder, WD
   Weiss, KB
   Blumenthal, D
AF Vogeli, Christine
   Shields, Alexandra E.
   Lee, Todd A.
   Gibson, Teresa B.
   Marder, William D.
   Weiss, Kevin B.
   Blumenthal, David
TI Multiple chronic conditions: Prevalence, health consequences, and
   implications for quality, care management, and costs
SO JOURNAL OF GENERAL INTERNAL MEDICINE
LA English
DT Article
DE chronic disease; comorbidity; prevalence; quality of health care
ID 3RD NATIONAL-HEALTH; ADVERSE DRUG EVENTS; METABOLIC SYNDROME; DISEASE
   MANAGEMENT; DEPRESSION CARE; OF-CARE; COMORBIDITY; ADULTS; ILLNESS;
   HOSPITALIZATION
AB Persons with multiple chronic conditions are a large and growing segment of the US population. However, little is known about how chronic conditions cluster, and the ramifications of having specific combinations of chronic conditions. Clinical guidelines and disease management programs focus on single conditions, and clinical research often excludes persons with multiple chronic conditions. Understanding how conditions in combination impact the burden of disease and the costs and quality of care received is critical to improving care for the 1 in 5 Americans with multiple chronic conditions. This Medline review of publications examining somatic chronic conditions co-occurring with 1 or more additional specific chronic illness between January 2000 and March 2007 summarizes the state of our understanding of the prevalence and health challenges of multiple chronic conditions and the implications for quality, care management, and costs.
C1 Massachusetts Gen Hosp, Dept Med, Inst Hlth Policy, Boston, MA 02114 USA.
   Harvard Univ, Sch Med, Boston, MA USA.
   Thomson Healthcare, Ann Arbor, MI USA.
   Northwestern Univ, Feinberg Sch Med, Inst Healthcare Studies, Chicago, IL 60611 USA.
   Edward Hines Jr VA Hosp, Ctr Complex Chron Care, Hines, IL 60141 USA.
C3 Harvard University; Harvard University Medical Affiliates; Massachusetts
   General Hospital; Harvard University; Harvard Medical School;
   Northwestern University; Feinberg School of Medicine; US Department of
   Veterans Affairs; Veterans Health Administration (VHA); Edward Hines Jr.
   VA Hospital
RP Vogeli, C (corresponding author), Massachusetts Gen Hosp, Dept Med, Inst Hlth Policy, 50 Staniford St,9th Floor, Boston, MA 02114 USA.
EM cvogeli@partners.org
RI Weiss, Kevin/MGA-2533-2025
OI Marder, William/0000-0002-7198-6933; Lee, Todd/0000-0003-3619-5367
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NR 56
TC 779
Z9 903
U1 6
U2 76
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0884-8734
EI 1525-1497
J9 J GEN INTERN MED
JI J. Gen. Intern. Med.
PD DEC
PY 2007
VL 22
SU 3
BP 391
EP 395
DI 10.1007/s11606-007-0322-1
PG 5
WC Health Care Sciences & Services; Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services; General & Internal Medicine
GA 239UM
UT WOS:000251543500005
PM 18026807
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Roenneberg, T
   Foster, RG
   Klerman, EB
AF Roenneberg, Till
   Foster, Russell G.
   Klerman, Elizabeth B.
TI The circadian system, sleep, and the health/disease balance: a
   conceptual review
SO JOURNAL OF SLEEP RESEARCH
LA English
DT Review
DE circadian; circadian medicine; conditional process model; health; humans
ID NIGHT-SHIFT WORK; SOCIAL JETLAG; RISK-FACTOR; ANTIBODY-RESPONSE;
   SUPRACHIASMATIC NUCLEUS; INFLUENZA VACCINATION; MORNING VACCINATION;
   METABOLIC SYNDROME; GHRELIN LEVELS; STROKE ONSET
AB The field of "circadian medicine" is a recent addition to chronobiology and sleep research efforts. It represents a logical step arising from the increasing insights into the circadian system and its interactions with life in urbanised societies; applying these insights to the health/disease balance at home and in the medical practice (outpatient) and clinic (inpatient). Despite its fast expansion and proliferating research efforts, circadian medicine lacks a formal framework to categorise the many observations describing interactions among the circadian system, sleep, and the health/disease balance. A good framework allows us to categorise observations and then assign them to one or more components with hypothesised interactions. Such assignments can lead to experiments that document causal (rather than correlational) relationships and move from describing observations to discovering mechanisms. This review details such a proposed formal framework for circadian medicine and will hopefully trigger discussion among our colleagues, so that the framework can be improved and expanded. As the basis of the framework for circadian medicine, we define "circadian health" and how it links to general health. We then define interactions among the circadian system, sleep, and the health/disease balance and put the framework into the context of the literature with examples from six domains of health/disease balance: fertility, cancer, immune system, mental health, cardiovascular, and metabolism.
C1 [Roenneberg, Till] Inst Med Psychol, Munich, Germany.
   [Roenneberg, Till] Inst Occupat Social & Environm Med, Munich, Germany.
   [Foster, Russell G.] Univ Oxford, Nuffield Dept Clin Neurosci, Sir Jules Thorn Sleep & Circadian Neurosci Inst S, New Biochem Bldg, Oxford, England.
   [Klerman, Elizabeth B.] Harvard Med Sch, Massachusetts Gen Hosp, Dept Neurol, Div Sleep Med, Boston, MA 02115 USA.
C3 University of Oxford; Harvard University; Harvard University Medical
   Affiliates; Massachusetts General Hospital; Harvard Medical School
RP Roenneberg, T (corresponding author), Inst Med Psychol, Munich, Germany.; Roenneberg, T (corresponding author), Inst Occupat Social & Environm Med, Munich, Germany.
EM Till.Roenneberg@med.uni-muenchen.de
OI FOSTER, RUSSELL/0000-0001-6055-2067
FU Projekt DEAL; BBSRC [BB/S015817/1] Funding Source: UKRI; National
   Institute of Neurological Disorders and Stroke [R01NS099055,
   U01NS114001] Funding Source: NIH RePORTER; National Institute on Drug
   Abuse [R21DA052861] Funding Source: NIH RePORTER
FX We would like to acknowledge Luisa Klaus Pilz and Nicoli Bertoul Xavier,
   whose exciting work on the relationship between circadian parameters and
   health parameters in the Brazilian Quilombo population has inspired the
   core of the framework "circadian health is associated with general
   health." Open Access funding enabled and organized by Projekt DEAL.
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NR 162
TC 36
Z9 38
U1 8
U2 33
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0962-1105
EI 1365-2869
J9 J SLEEP RES
JI J. Sleep Res.
PD AUG
PY 2022
VL 31
IS 4
AR e13621
DI 10.1111/jsr.13621
EA JUN 2022
PG 14
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 3F6LR
UT WOS:000806952600001
PM 35670313
OA hybrid, Green Published, Green Accepted
DA 2025-06-11
ER

PT J
AU Teobaldi, E
   Albert, U
   Di Salvo, G
   Mencacci, C
   Rosso, G
   Salvi, V
   Maina, G
AF Teobaldi, Elena
   Albert, Umberto
   Di Salvo, Gabriele
   Mencacci, Claudio
   Rosso, Gianluca
   Salvi, Virginio
   Maina, Giuseppe
TI Manic-Depressive Cycles in Bipolar Disorder: Clinical and Treatment
   Implications
SO PSYCHOPATHOLOGY
LA English
DT Article
DE Bipolar disorder; Course sequence; Manic-depressive cycle;
   Mania-depression-free interval; Depression-mania-interval
ID LITHIUM RESPONSE; METABOLIC SYNDROME; PREVIOUS PATTERN; ILLNESS;
   SEQUENCE; POLARITY; EPISODE; PROPHYLAXIS; PREVALENCE; PREDICTOR
AB Introduction: Cycle patterns of bipolar disorders (BDs) have been previously shown to be associated with clinical characteristics and response to lithium salts. Here, we evaluated the distribution of different types of manic-depressive cycles in a large sample of patients with BD. The associations between a mania-depression-interval (MDI) course and depression-mania-interval (DMI) course with sociodemographic/clinical factors were also assessed in order to define specific clinical profiles. Methods: In this cross-sectional study, 806 patients with BD admitted to the Psychiatric Unit of San Luigi Gonzaga Hospital in Orbassano and Molinette Hospital in Turin, Italy, were recruited. Patients were grouped according to the following course patterns: MDI, DMI, continuous cycling (CC, <4 episodes/year without intervals), rapid cycling (RC, >= 4 episodes/year), and irregular (IRR) cycling. We compared several sociodemographic and clinical variables in an MDI versus DMI course by means of ANOVA and Pearson chi(2) with Bonferroni correction. Results: Bipolar cycles were distributed as follows: 50.2% IRR course, 31.5% MDI course, 16% DMI course, 1.2% CC, and 1% RC. Compared to DMI course, patients with an MDI course were more often men, younger, with an earlier onset, a manic polarity onset, and more lifetime compulsory admissions. They were more frequently treated with lithium and antipsychotics. Patients with a DMI course had older age at diagnosis and at first mood-stabilizer treatment and were more often misdiagnosed with a major depressive disorder. These patients were more commonly treated with anticonvulsants, and they had more frequently failed treatment trials with lithium salts in the past. Conclusion: This study supports the utility of classifying BD according to their course patterns. This classification holds prognostic as well as therapeutic implications.
C1 [Teobaldi, Elena; Di Salvo, Gabriele; Rosso, Gianluca; Maina, Giuseppe] Univ Torino, Dept Neurosci Rita Levi Montalcini, Turin, Italy.
   [Albert, Umberto] Univ Trieste, UCO Clin Psichiatr, Dept Med Surg & Hlth Sci, Trieste, Italy.
   [Albert, Umberto] Azienda Sanit Univ Giuliano Isontina, ASUGI, Trieste, Italy.
   [Mencacci, Claudio; Salvi, Virginio] ASST Fatebenefratelli Sacco, Dept Neurosci, Pzza Principessa Clotilde 3, IT-20121 Milan, Italy.
   [Rosso, Gianluca; Maina, Giuseppe] San Luigi Gonzaga Univ Hosp, Psychiat Unit, Turin, Italy.
C3 University of Turin; University of Trieste; University of Turin;
   University Turin Hospital; Azienda Ospedaliero-Universitaria San Luigi
   Gonzaga
RP Salvi, V (corresponding author), ASST Fatebenefratelli Sacco, Dept Neurosci, Pzza Principessa Clotilde 3, IT-20121 Milan, Italy.
EM virginiosalvi@gmail.com
RI Rosso, Gianluca/N-6136-2016; Maina, Giuseppe/AAC-7158-2022; Di Salvo,
   Gabriele/J-5199-2018
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NR 41
TC 2
Z9 2
U1 0
U2 9
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0254-4962
EI 1423-033X
J9 PSYCHOPATHOLOGY
JI Psychopathology
PD APR
PY 2021
VL 54
IS 2
BP 98
EP 105
DI 10.1159/000513314
EA FEB 2021
PG 8
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA RQ5GD
UT WOS:000621524900001
PM 33626525
DA 2025-06-11
ER

PT J
AU Abdullahi, A
   Wong, TWL
   Ng, SSM
AF Abdullahi, Auwal
   Wong, Thomson W. L.
   Ng, Shamay S. M.
TI Understanding the potential mechanisms of disease modifying effects of
   physical activity and exercise in people with schizophrenia
SO SCHIZOPHRENIA RESEARCH
LA English
DT Article
DE Schizophrenia; Neurotrophins; Cardiorespiratory fitness; Enzyme linked
   immunosorbent assay; Exercise
ID WHITE-MATTER INTEGRITY; BRAIN VOLUME CHANGES; AEROBIC EXERCISE;
   NEUROTROPHIC FACTOR; CARDIORESPIRATORY FITNESS; METABOLIC SYNDROME;
   INDIVIDUALS; PLASTICITY; BDNF; NEUROCOGNITION
AB Schizophrenia is a serious chronic mental health problem that usually starts during adolescence and early childhood. It is characterized by positive symptoms (delusions, hallucinations and grossly disorganized speech and behaviour), negative symptoms (apathy, isolation and diminished affect), and cognitive impairment that negatively affect quality of life. Its treatments include the use of pharmacological interventions, exercise, noninvasive brain stimulation and cognitive remediation training. Exercise is a very simple and cost-effective intervention. However, it is important the mechanisms of its effects are understood so that it can be trusted in clinical practice. In addition, understanding the mechanisms is important for its modification and safe use. Similarly, it may help provide the basis for invention of safe and cost-effective pharmacological or alternative therapies. From the literature, the mechanisms of diseases modifying effects of exercise seem to include increased cardiorespiratory fitness, biochemical changes (increased level of BDNF, increased N-acetylaspartate (NAA)/cr (creatine) ratio, decreased level of triglycerides, increased high density lipoprotein (HDL) and decreased salivary cortisol), structural changes (increase in cerebral volume, increased white matter integrity and increased cortical thickness) and anthropometric changes (reduced body weight and body mass index (BMI), increased muscular strength and decreased waist-hip ratio or waist circumference or hip circumference).
C1 [Abdullahi, Auwal; Wong, Thomson W. L.; Ng, Shamay S. M.] Hong Kong Polytech Univ, Dept Rehabil Sci, Hong Kong, Peoples R China.
C3 Hong Kong Polytechnic University
RP Ng, SSM (corresponding author), Hong Kong Polytech Univ, Dept Rehabil Sci, Hong Kong, Peoples R China.
EM aabdullahi.pth@buk.edu.ng; shamay.ng@polyu.edu.hk
RI Abdullahi, Auwal/AAD-1977-2020; Ng, Shamay/E-2731-2016
OI Abdullahi, Auwal/0000-0001-9214-3313
FU Research Centre for Chinese Medicine Innovation of The Hong Kong
   Polytechnic University [P0041139]; PolyU Distinguished Postdoctoral
   Fellowship Scheme [P0035217]
FX This work was supported by the research of the Research Centre for
   Chinese Medicine Innovation of The Hong Kong Polytechnic University
   (Ref. No. P0041139) awarded to Prof Shamay Ng and her team; and PolyU
   Distinguished Postdoctoral Fellowship Scheme (P0035217).
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NR 103
TC 1
Z9 1
U1 2
U2 3
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0920-9964
EI 1573-2509
J9 SCHIZOPHR RES
JI Schizophr. Res.
PD DEC
PY 2024
VL 274
BP 381
EP 391
DI 10.1016/j.schres.2024.10.004
EA OCT 2024
PG 11
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA K8L4B
UT WOS:001346351500001
PM 39490219
DA 2025-06-11
ER

PT J
AU Sruthi, KG
   John, SM
   David, SM
AF Sruthi, K. G.
   John, Sushil Mathew
   David, Sam Marconi
TI Assessment of obesity in the Indian setting: A clinical review
SO CLINICAL EPIDEMIOLOGY AND GLOBAL HEALTH
LA English
DT Review
DE Obesity; Lifestyle; Key indicators; Assessment; Health
ID NECK CIRCUMFERENCE; BODY-COMPOSITION; MARKER; RISK
AB Background: Obesity is an important public health concern, one of the main lifestyle illnesses leading to chronic diseases like metabolic syndrome, diabetes, cardiovascular diseases, cancers, depression, and stroke. Hence diagnosis and management of obesity as early as possible are essential to prevent the development of these diseases. The present paper reviews some of the key indicators useful in the assessment of obesity.Methods: We collected and reviewed different articles on obesity. Conclusion: Obesity is a serious non-communicable disease associated with multiple risk factors leading to multiple chronic diseases. Early identification for management is essential to reduce the risk factors of the disease. Proper diet and adequate physical activity should be followed regularly to combat the condition. For diet, eating on time, eating healthy fruits and vegetables, and avoiding junk and processed foods would be healthy and Physical activity of 30 min a day is recommended for all individuals to prevent obesity in the future.
C1 [Sruthi, K. G.; David, Sam Marconi] CMC, Dept Community Hlth, Vellore, India.
   [John, Sushil Mathew] CMC, LCECU, Vellore, India.
C3 Christian Medical College & Hospital (CMCH) Vellore; Christian Medical
   College & Hospital (CMCH) Vellore
RP Sruthi, KG (corresponding author), CMC, Dept Community Hlth, Vellore, India.
EM kgsruthi@gmail.com
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NR 24
TC 9
Z9 9
U1 0
U2 0
PU ELSEVIER - DIVISION REED ELSEVIER INDIA PVT LTD
PI NEW DELHI
PA 17-A/1 MAIN RING ROAD, LAJPAT NAGAR IV, NEW DELHI, 110024, INDIA
SN 2452-0918
EI 2213-3984
J9 CLIN EPIDEMIOL GLOB
JI Clin. Epidemiol. Glob. Health
PD SEP-OCT
PY 2023
VL 23
AR 101348
DI 10.1016/j.cegh.2023.101348
EA AUG 2023
PG 4
WC Public, Environmental & Occupational Health
WE Emerging Sources Citation Index (ESCI)
SC Public, Environmental & Occupational Health
GA R2XH6
UT WOS:001063025800001
OA gold
DA 2025-06-11
ER

PT J
AU Teigen, L
   Boes, CJ
AF Teigen, Levi
   Boes, Christopher J.
TI An evidence-based review of oral magnesium supplementation in the
   preventive treatment of migraine
SO CEPHALALGIA
LA English
DT Review
DE Magnesium; migraine; migraine prophylaxis
ID SERUM IONIZED MAGNESIUM; QUALITY STANDARDS SUBCOMMITTEE; CORTICAL
   SPREADING DEPRESSION; AMERICAN HEADACHE SOCIETY; TENSION-TYPE HEADACHE;
   METABOLIC SYNDROME; DIETARY MAGNESIUM; DOUBLE-BLIND; INTRACELLULAR
   MAGNESIUM; MENSTRUAL MIGRAINE
AB Background Migraine is an incompletely understood, debilitating disorder that lacks a universally effective treatment. Magnesium participates in a variety of biochemical processes related to migraine pathophysiology, and a deficiency could contribute to migraine development.
   Methods A review of the literature from 1990 to the present on magnesium and migraine was conducted.
   Review The authors identified 16 studies aimed at magnesium status assessment in migraine, and four intervention trials assessing the efficacy of oral magnesium supplementation, independent of other therapies, in the prevention of migraine.
   Conclusion The strength of evidence supporting oral magnesium supplementation is limited at this time. With such limited evidence, a more advantageous alternative to magnesium supplementation, in patients willing to make lifestyle changes, may be to focus on increasing dietary magnesium intake.
C1 [Teigen, Levi; Boes, Christopher J.] Mayo Clin, Coll Med, Rochester, MN 55902 USA.
   [Teigen, Levi] Mayo Clin, Dept Clin Dietet, Rochester, MN 55902 USA.
   [Boes, Christopher J.] Mayo Clin, Dept Neurol, Rochester, MN 55902 USA.
C3 Mayo Clinic; Mayo Clinic; Mayo Clinic
RP Teigen, L (corresponding author), Mayo Clin, Dept Clin Dietet, Dept Endocrinol, Mayo Clin Hosp, St Marys Campus,Joseph Bldg MN-98,1216 Second St, Rochester, MN 55902 USA.
EM teigen.levi@mayo.edu
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NR 76
TC 46
Z9 48
U1 0
U2 29
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0333-1024
EI 1468-2982
J9 CEPHALALGIA
JI Cephalalgia
PD SEP
PY 2015
VL 35
IS 10
BP 912
EP 922
DI 10.1177/0333102414564891
PG 11
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA CO8NC
UT WOS:000359425200010
PM 25533715
OA Bronze
DA 2025-06-11
ER

PT J
AU Tostain, JL
   Blanc, F
AF Tostain, Jacques L.
   Blanc, Francois
TI Testosterone deficiency: a common, unrecognized syndrome
SO NATURE CLINICAL PRACTICE UROLOGY
LA English
DT Review
DE aging; diagnosis; hypogonadism; male; testosterone
ID MIDDLE-AGED MEN; SYMPTOMATIC ANDROGEN DEFICIENCY; SERUM TESTOSTERONE;
   BIOAVAILABLE TESTOSTERONE; METABOLIC SYNDROME; ADULT MEN; BIOCHEMICAL
   ASSESSMENT; KLINEFELTER-SYNDROME; REPLACEMENT THERAPY; ENDOCRINE-SOCIETY
AB Testosterone deficiency syndrome (TDS) refers to the clinical signs and symptoms that result from an abnormally low testosterone level. Men with ` classic' hypogonadism can have unequivocally low testosterone levels and typical symptoms and signs. By contrast, the age-related decline of testosterone levels can be responsible for ambiguous clinical pictures, which can potentially be misinterpreted as part of the aging process or depression. Nevertheless, this decline can have detrimental effects on quality of life and on the function of multiple organ systems. TDS is underdiagnosed -its overall prevalence varies from 6% to 9.5% in community-dwelling men aged 40 -70 years, and rises to 15 -30% in diabetic or obese men -and undertreated; less than 10% of men with TDS receive treatment. This Review highlights potential pitfalls in the diagnosis of both clinical and biochemical components of TDS.
C1 [Tostain, Jacques L.] Univ St Etienne, Sch Med, St Etienne, France.
   [Tostain, Jacques L.; Blanc, Francois] N Acad Hosp, Urol Androl Dept, St Etienne, France.
C3 Universite Jean Monnet; CHU de St Etienne
RP Tostain, JL (corresponding author), CHU, Dept Urol Androl, F-42055 St Etienne 2, France.
EM jacques.tostain@chu-st-etienne.fr
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NR 61
TC 57
Z9 57
U1 0
U2 3
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 1743-4270
J9 NAT CLIN PRACT UROL
JI Nat. Clin. Pract. Urol.
PD JUL
PY 2008
VL 5
IS 7
BP 388
EP 396
DI 10.1038/ncpuro1167
PG 9
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 322LD
UT WOS:000257375600010
PM 18604225
DA 2025-06-11
ER

PT J
AU Liu, X
   Tou, NX
   Gao, Q
   Gwee, XY
   Wee, SL
   Ng, TP
AF Liu, Xiao
   Tou, Nien Xiang
   Gao, Qi
   Gwee, Xinyi
   Wee, Shiou Liang
   Ng, Tze Pin
TI Frailty and risk of cardiovascular disease and mortality
SO PLOS ONE
LA English
DT Article
ID OLDER-ADULTS; METABOLIC SYNDROME; MUSCLE MASS; GAIT SPEED; HEALTH;
   INTERVENTIONS; ASSOCIATION; STRENGTH; WOMEN; HEART
AB Background Prospective cohort studies suggest that frailty is associated with an increased risk of incident cardiovascular disease (CVD) morbidity and mortality, but their mechanistic and developmental relations are not fully understood. We investigated whether frailty predicted an increased risk of incident nonfatal and fatal CVD among community-dwelling older adults.
   Methods A population cohort of 5015 participants aged 55 years and above free of CVD at baseline was followed for up to 10 years. Pre-frailty and frailty were defined as the presence of 1-2 and 3-5 modified Fried criteria (unintentional weight loss, weakness, slow gait speed, exhaustion, and low physical activity), incident CVD events as newly diagnosed registered cases of myocardial infarction (MI), stroke, and CVD-related mortality (ICD 9: 390 to 459 or ICD-10: I00 to I99). Covariate measures included traditional cardio-metabolic and vascular risk factors, medication therapies, Geriatric Depression Scale (GDS), Mini-Mental State Exam (MMSE), and blood biomarkers (haemoglobin, albumin, white blood cell counts and creatinine).
   Results Pre-frailty and frailty were significantly associated with elevated HR = 1.26 (95%CI: 1.02-1.56) and HR = 1.54 (95%CI:1.00-2.35) of overall CVD, adjusted for cardio-metabolic and vascular risk factors and medication therapies, but not after adjustment for GDS depression and MMSE cognitive impairment. The HR of association between frailty status and both CVD mortality and overall mortality, however, remained significantly elevated after full adjustment for depression, cognitive and blood biomarkers.
   Conclusion Frailty was associated with increased risk of CVD morbidity and especially mortality, mediated in parts by traditional cardio-metabolic and vascular risk factors, and co-morbid depression and associated cognitive impairment and chronic inflammation. Given that pre-frailty and frailty are reversible by multi-domain lifestyle and health interventions, there is potential benefits in reducing cardiovascular diseases burden and mortality from interventions targeting pre-frailty and early frailty population.
C1 [Liu, Xiao; Tou, Nien Xiang; Wee, Shiou Liang; Ng, Tze Pin] Geriatr Educ & Res Inst, Singapore, Singapore.
   [Gao, Qi; Gwee, Xinyi; Ng, Tze Pin] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Psychol Med, Gerontol Res Programme, Singapore, Singapore.
   [Wee, Shiou Liang] Singapore Inst Technol, Hlth & Social Sci Cluster, Singapore, Singapore.
C3 National University of Singapore; Singapore Institute of Technology
RP Ng, TP (corresponding author), Geriatr Educ & Res Inst, Singapore, Singapore.
EM pcmngtp@nus.edu.sg
RI Wee, Shiou-Liang/H-7115-2019; Tou, Nien Xiang/HGB-5033-2022
OI Ng, Tze Pin/0000-0001-9585-855X; Tou, Nien Xiang/0000-0003-1836-5692;
   Wee, Shiou-Liang/0000-0002-7853-4112
FU Agency for Science Technology and Research (A.STAR) Biomedical Research
   Council (BMRC) [08/1/21/19/567]; National Medical Research Council
   [NMRC/1108/2007]
FX The study was supported by research grants from the Agency for Science
   Technology and Research (A.STAR) Biomedical Research Council (BMRC)
   (https://www.a-star.edu.sg/)[Grant: 08/1/21/19/567] and from the
   National Medical Research Council (https://www.nmrc.gov.sg/) [Grant:
   NMRC/1108/2007]. NTP received both fundings. The funders had no role in
   study design, data collection and analysis, decision to publish, or
   preparation of the manuscript.
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NR 39
TC 30
Z9 30
U1 3
U2 9
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD SEP 19
PY 2022
VL 17
IS 9
AR e0272527
DI 10.1371/journal.pone.0272527
PG 13
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 8Z4UD
UT WOS:000933374300008
PM 36121826
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Lustig, RH
AF Lustig, Robert H.
TI Fructose: It's "Alcohol Without the Buzz"
SO ADVANCES IN NUTRITION
LA English
DT Article; Proceedings Paper
CT Symposium on Fructose, Sucrose and High Fructose Corn Syrup - Modern
   Scientific Findings and Health Implications held at the ASN Scientific
   Sessions and Annual Meeting at Experimental Biology
CY APR 22, 2012
CL San Diego, CA
SP Amer Soc Nutr (ASN)
ID DE-NOVO LIPOGENESIS; ENDOPLASMIC-RETICULUM STRESS; HEPATIC
   INSULIN-RESISTANCE; FATTY LIVER-DISEASE; GLUCOSE-SWEETENED BEVERAGES;
   CONTROLLED FEEDING TRIALS; EXCESSIVE SUGAR INTAKE; METABOLIC SYNDROME;
   ETHANOL EXPOSURE; OXIDATIVE STRESS
AB What do the Atkins Diet and the traditional Japanese diet have in common? The Atkins Diet is low in carbohydrate and usually high in fat; the Japanese diet is high in carbohydrate and usually low in fat. Yet both work to promote weight loss. One commonality of both diets is that they both eliminate the monosaccharide fructose. Sucrose (table sugar) and its synthetic sister high fructose corn syrup consist of 2 molecules, glucose and fructose. Glucose is the molecule that when polymerized forms starch, which has a high glycemic index, generates an insulin response, and is not particularly sweet. Fructose is found in fruit, does not generate an insulin response, and is very sweet. Fructose consumption has increased worldwide, paralleling the obesity and chronic metabolic disease pandemic. Sugar (i.e., fructose-containing mixtures) has been vilified by nutritionists for ages as a source of "empty calories," no different from any other empty calorie. However, fructose is unlike glucose. In the hypercaloric glycogen-replete state, intermediary metabolites from fructose metabolism overwhelm hepatic mitochondrial capacity, which promotes de novo lipogenesis and leads to hepatic insulin resistance, which drives chronic metabolic disease. Fructose also promotes reactive oxygen species formation, which leads to cellular dysfunction and aging, and promotes changes in the brain's reward system, which drives excessive consumption. Thus, fructose can exert detrimental health effects beyond its calories and in ways that mimic those of ethanol, its metabolic cousin. Indeed, the only distinction is that because fructose is not metabolized in the central nervous system, it does not exert the acute neuronal depression experienced by those imbibing ethanol. These metabolic and hedonic analogies argue that fructose should be thought of as "alcohol without the buzz." Adv. Nutr. 4: 226-235, 2013.
C1 [Lustig, Robert H.] Univ Calif San Francisco, Dept Pediat, San Francisco, CA 94143 USA.
   [Lustig, Robert H.] Univ Calif San Francisco, Philip R Lee Inst Hlth Policy Studies, San Francisco, CA 94143 USA.
C3 University of California System; University of California San Francisco;
   University of California System; University of California San Francisco
RP Lustig, RH (corresponding author), Univ Calif San Francisco, Dept Pediat, San Francisco, CA 94143 USA.
EM rlustig@peds.ucsf.edu
RI Lustig, Robert/O-9380-2019
FU NIDDK NIH HHS [R01DK089216] Funding Source: Medline
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NR 101
TC 140
Z9 155
U1 0
U2 96
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 2161-8313
EI 2156-5376
J9 ADV NUTR
JI Adv. Nutr.
PD MAR
PY 2013
VL 4
IS 2
BP 226
EP 235
DI 10.3945/an.112.002998
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Nutrition & Dietetics
GA 120HJ
UT WOS:000317161100011
PM 23493539
OA Bronze, Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU El Midaoui, A
   Lungu, C
   Wang, H
   Wu, LY
   Robillard, C
   DeBlois, D
   Couture, R
AF El Midaoui, Adil
   Lungu, Calin
   Wang, Hui
   Wu, Lingyun
   Robillard, Caroline
   DeBlois, Denis
   Couture, Rejean
TI Impact of α-lipoic acid on liver peroxisome proliferator-activated
   receptor-α, vascular remodeling, and oxidative stress in
   insulin-resistant rats
SO CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
LA English
DT Article
DE hypertension; insulin resistance; PPAR-alpha; oxidative stress;
   alpha-lipoic acid; vascular remodeling; liver
ID SUPEROXIDE ANION PRODUCTION; SMOOTH-MUSCLE-CELLS; PPAR-ALPHA; SYSTOLIC
   HYPERTENSION; METABOLIC SYNDROME; DIABETES-MELLITUS; GAMMA AGONISTS;
   PROTEIN-KINASE; HYPERTROPHY; PREVENTION
AB This study sought to determine the impact of alpha-lipoic acid (LA) on superoxide anion (O(2)(center dot-)) production and peroxisome proliferator-activated receptor-alpha (PPAR alpha) expression in liver tissue, plasma free fatty acids (FFA), and aortic remodeling in a rat model of insulin resistance. Sprague Dawley rats (50-75 g) were given either tap water or a drinking solution containing 10% D-glucose for 14 weeks, combined with a diet with or without LA supplement. O(2)(center dot-) production was measured by lucigenin chemiluminescence, and PPAR-alpha expression by Western blotting. Cross-sectional area (CSA) of the aortic media and lumen and number of smooth muscle cells (SMC) were determined histologically. Glucose increased systolic blood pressure (SBP), plasma levels of glucose and insulin, and insulin resistance (HOMA index). All of these effects were attenuated by LA. Whereas glucose had no effect on liver PPAR-alpha protein level, it decreased plasma FFA. LA decreased the aortic and liver O(2)(center dot-) production, body weight, and plasma FFA levels in control and glucose-treated rats. Liver PPAR-alpha protein levels were increased by LA, and negatively correlated with plasma FFA. Medial CSA was reduced in all glucose-treated rats, and positively correlated with plasma FFA but not with SBP or aortic O(2)(center dot-) production. Glucose also reduced aortic lumen area, so that the media-to-lumen ratio remained unchanged. The ability of LA to lower plasma FFA appears to be mediated, in part, by increased hepatic PPAR-alpha expression, which may positively affect insulin resistance. Glucose-fed rats may serve as a unique model of aortic atrophic remodeling in hypertension and early metabolic syndrome.
C1 [El Midaoui, Adil; Lungu, Calin; Couture, Rejean] Univ Montreal, Fac Med, Dept Physiol, Montreal, PQ H3C 3J7, Canada.
   [Wang, Hui; Wu, Lingyun] Univ Saskatchewan, Dept Pharmacol, Coll Med, Saskatoon, SK S7N 5E5, Canada.
   [Robillard, Caroline; DeBlois, Denis] Univ Montreal, Fac Med, Dept Pharmacol, Montreal, PQ H3C 3J7, Canada.
C3 Universite de Montreal; University of Saskatchewan; Universite de
   Montreal
RP Couture, R (corresponding author), Univ Montreal, Fac Med, Dept Physiol, Montreal, PQ H3C 3J7, Canada.
EM rejean.couture@umontreal.ca
RI Wu, Lingyun/HRD-0014-2023
FU Heart and Stroke Foundation of Quebec; Canadian Institutes of Health
   Research; Canadian Hypertension Society
FX This work was supported by grants from the Heart and Stroke Foundation
   of Quebec (R.C.) and the Canadian Institutes of Health Research (D.D.).
   Adil El Midaoui was supported by a post-doctoral Fellowship awarded
   jointly by the Canadian Institutes of Health Research and the Canadian
   Hypertension Society. The expert technical assistance of Diane Papin is
   gratefully acknowledged.
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NR 40
TC 12
Z9 14
U1 0
U2 3
PU CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS
PI OTTAWA
PA 1200 MONTREAL ROAD, BUILDING M-55, OTTAWA, ON K1A 0R6, CANADA
SN 0008-4212
J9 CAN J PHYSIOL PHARM
JI Can. J. Physiol. Pharmacol.
PD OCT
PY 2011
VL 89
IS 10
BP 743
EP 751
DI 10.1139/Y11-072
PG 9
WC Pharmacology & Pharmacy; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Physiology
GA 837CQ
UT WOS:000296169100006
PM 21919742
DA 2025-06-11
ER

PT J
AU Carranza, A
   Litterio, MC
   Prince, PD
   Mayer, MA
   Ingaramo, PI
   Ronco, MT
   Peredo, HA
   Puyó, AM
   Galleano, M
AF Carranza, A.
   Litterio, M. C.
   Prince, P. D.
   Mayer, M. A.
   Ingaramo, P. I.
   Ronco, M. T.
   Peredo, H. A.
   Puyo, A. M.
   Galleano, M.
TI Lipopolysaccharide (LPS) induction of nitric oxide synthase-2 and
   cyclooxygenase-2 is impaired in fructose overloaded rats
SO LIFE SCIENCES
LA English
DT Article
DE Metabolic syndrome; Oxidative stress; Nitric oxide; Prostanoids; Nitric
   oxide synthase-2; Cyclooxygenase-2; Insulin resistance; Inflammation
ID INSULIN-RESISTANCE; DIABETIC-RATS; ACTIVATION; EXPRESSION;
   FRUCTOSE-1,6-BISPHOSPHATE; INFLAMMATION; ENDOTOXEMIA; INVOLVEMENT;
   INFECTIONS; MECHANISMS
AB Aims: Fructose (F) overload in rats induces metabolic dysfunctions that resemble the human metabolic syndrome. In this paper, we aimed to investigate the response of F overload rats to lipopolysaccharide (LPS) challenge in terms of nitric oxide (NO) production and prostanoids (PR) release.
   Main methods: NO blood steady-state concentration was monitored through the detection of nitrosylhemoglobin complexes (NO-Hb) by electronic spin resonance. Production of 6-keto PGF(1)alpha, PGE(2), PGF(2)alpha and TXB2 was measured in aorta and mesenteric beds by HPLC. Western blot analysis was used to examine the changes in the expression levels of NOS-2 and COX-2 in aorta.
   Key findings: Our results showed that increases in NO circulating steady-state concentration and PR production by aorta and mesenteric beds 6 h after LPS administration were significantly attenuated in F overload rats with respect to control animals. Oxidative stress parameters were equally affected in the presence or absence of the F treatment. Aorta protein levels of NOS-2 and COX-2, two enzymes inducible by LPS, were significantly lower in F overload rats with respect to control rats at the end of the treatment (-39% and -61% for NOS-2 and COX-2 respectively).
   Significance: These results suggest that the metabolic alterations established by 15 weeks of F overload should affect the response to LPS challenge due to an attenuation in the induction of NOS-2 and COX-2. This effect would be one of the components contributing to abnormalities in the course of the inflammatory response in other conditions associated to insulin resistance, such as diabetes. (C) 2010 Elsevier Inc. All rights reserved.
C1 [Litterio, M. C.; Prince, P. D.; Galleano, M.] Univ Buenos Aires, CONICET, Sch Pharm & Biochem, Phys Chem PRALIB, Buenos Aires, DF, Argentina.
   [Carranza, A.; Mayer, M. A.; Peredo, H. A.; Puyo, A. M.] Univ Buenos Aires, INFIBIOC, Buenos Aires, DF, Argentina.
   [Ingaramo, P. I.; Ronco, M. T.] Natl Univ Rosario, CONICET, IFISE, Buenos Aires, DF, Argentina.
C3 Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET);
   University of Buenos Aires; University of Buenos Aires; National
   University of Rosario; Consejo Nacional de Investigaciones Cientificas y
   Tecnicas (CONICET)
RP Galleano, M (corresponding author), Univ Buenos Aires, CONICET, Sch Pharm & Biochem, Phys Chem PRALIB, Junin 956,2nd Floor,C1113AAD, Buenos Aires, DF, Argentina.
EM mgallean@ffyb.uba.ar
RI Prince, Paula/O-5318-2019
OI Prince, Paula Denise/0000-0002-7075-4014; Ingaramo,
   Paola/0000-0002-1117-6824; Ronco, Maria Teresa/0000-0003-0559-2095;
   Carranza, Andrea/0000-0001-8352-5504
FU Secretaria de Ciencia y Tecnica (Universidad de Buenos Aires) [B109,
   B802]; Consejo Nacional de lnvestigaciones Cientificas y Tecnicas
   (CONICET) [PIP 2109/00, PIP 5497]; Agencia Nacional de Promocion
   Cientifica y Tecnologica (ANPCyT) [BID PICT 00994]
FX This study was supported by grants from the Secretaria de Ciencia y
   Tecnica (Universidad de Buenos Aires) (B109 and B802), Consejo Nacional
   de lnvestigaciones Cientificas y Tecnicas (CONICET) (PIP 2109/00 and PIP
   5497) and Agencia Nacional de Promocion Cientifica y Tecnologica
   (ANPCyT) (BID PICT 00994) AC, HAP and MG are members of CONICET. MCL is
   an ANPCyT fellow.
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NR 48
TC 4
Z9 6
U1 0
U2 0
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0024-3205
EI 1879-0631
J9 LIFE SCI
JI Life Sci.
PD FEB 14
PY 2011
VL 88
IS 7-8
BP 307
EP 313
DI 10.1016/j.lfs.2010.12.005
PG 7
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA 719QU
UT WOS:000287224300004
PM 21146548
DA 2025-06-11
ER

PT J
AU Albadawi, H
   Oklu, R
   Cormier, NR
   O'Keefe, RM
   Heaton, JT
   Kobler, JB
   Austen, WG
   Watkins, MT
AF Albadawi, Hassan
   Oklu, Rahmi
   Cormier, Nicholas R.
   O'Keefe, Ryan M.
   Heaton, James T.
   Kobler, James B.
   Austen, William G.
   Watkins, Michael T.
TI Hind limb ischemia-reperfusion injury in diet-induced obese mice
SO JOURNAL OF SURGICAL RESEARCH
LA English
DT Article
DE Limb ischemia; Reperfusion injury; Diabetes; Diet-induced obesity;
   Insulin resistance; Muscle regeneration; Inflammation; Muscle
   contraction; Metabolism; Phosphoinositide-3-kinase-protein kinase B/Akt
   pathway
ID QUALITY-OF-LIFE; INFRAGENICULATE BYPASS-SURGERY; SKELETAL-MUSCLE;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; DIABETIC COMPLICATIONS;
   NONDIABETIC PATIENTS; BODY-COMPOSITION; OLDER-ADULTS; FATTY-ACIDS
AB Background: Obesity is a major risk factor for the development of diabetes. Limb ischemia -reperfusion injury (IR) is a common clinical problem in diabetics who have compromised lower extremity perfusion. This study compared the histologic, metabolic, and functional outcomes after hind limb IR in diet-induced obese (DIO) and non-diabetic (ND) mice during the acute and the regenerative phases of IR.
   Methods: DIO and ND mice were subjected to 1.5 hunilateral hind limb ischemia followed by 1-or 28-d IR. Muscle morphology, metabolic, and genomic stress were evaluated at days 1 and 28 IR; Acute inflammation and thrombosis were only measured at day-1 IR. At day 28, IR, skeletal muscle contractility, and maturation were also assessed.
   Results: At day-1 IR, similar levels of acute muscle fiber necrosis were seen in both groups. DIO mice demonstrated substantially greater inflammatory, prothrombotic, and genomic stress responses, which were also associated with a greater reduction in energy substrates and Akt phosphorylation. At 28d, there was no difference in the peak forces generated in the hind limbs for the two groups. DIO mice had reduced fatigue resistance compared with ND and larger areas of fat accumulation although there was no significant difference in muscle fiber maturation.
   Conclusions: DIO mice had an exacerbated acute response to IR with enhanced metabolic deficit, fat accumulation, and defective functional recovery during the regenerative phase of IR. These changes in fatigue resistance reflect compromised functional recovery after IR injury and have relevance for the functional recovery of patients with metabolic syndrome and insulin resistance. (C) 2014 Elsevier Inc. All rights reserved.
C1 [Albadawi, Hassan; Heaton, James T.; Kobler, James B.; Austen, William G.; Watkins, Michael T.] Massachusetts Gen Hosp, Dept Surg, Boston, MA 02114 USA.
   [Albadawi, Hassan; Oklu, Rahmi; Cormier, Nicholas R.; O'Keefe, Ryan M.; Heaton, James T.; Kobler, James B.; Austen, William G.; Watkins, Michael T.] Harvard Univ, Sch Med, Boston, MA USA.
   [Albadawi, Hassan; Cormier, Nicholas R.; O'Keefe, Ryan M.; Watkins, Michael T.] Massachusetts Gen Hosp, Dept Radiol, Div Vasc & Endovasc Surg, Boston, MA 02114 USA.
   [Oklu, Rahmi] Massachusetts Gen Hosp, Div Vasc Imaging & Intervent, Boston, MA 02114 USA.
   [Heaton, James T.; Kobler, James B.] Massachusetts Gen Hosp, Ctr Laryngeal Surg & Voice Rehabil, Boston, MA 02114 USA.
   [Austen, William G.] Massachusetts Gen Hosp, Div Plast & Reconstruct Surg, Boston, MA 02114 USA.
C3 Harvard University; Harvard University Medical Affiliates; Massachusetts
   General Hospital; Harvard University; Harvard Medical School; Harvard
   University; Harvard University Medical Affiliates; Massachusetts General
   Hospital; Harvard University; Harvard University Medical Affiliates;
   Massachusetts General Hospital; Harvard University; Harvard University
   Medical Affiliates; Massachusetts General Hospital; Harvard University;
   Harvard University Medical Affiliates; Massachusetts General Hospital
RP Albadawi, H (corresponding author), Massachusetts Gen Hosp, Vasc Res Lab, Div Vasc & Endovasc Surg, 70 Blossom St, Boston, MA 02114 USA.
EM albadawi1@msn.com
RI oklu, rahmi/AAY-4676-2021
OI Oklu, Rahmi/0000-0003-4984-1778
FU NIH [RO1 AR055843]; Pacific Vascular Research Foundation; Department of
   Surgery, Division of Vascular and Endovascular Surgery (The Rosenberg
   Fund); American College of Phlebology; Department of Radiology, Division
   of Vascular Imaging and Intervention
FX MTW is the Isenberg Scholar in Academic Surgery at the Massachusetts
   General Hospital. This study was supported by NIH grant RO1 AR055843
   (MTW), Pacific Vascular Research Foundation, the Department of Surgery,
   Division of Vascular and Endovascular Surgery (The Rosenberg Fund). RO
   is funded by the American College of Phlebology and the Department of
   Radiology, Division of Vascular Imaging and Intervention.
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NR 45
TC 23
Z9 24
U1 0
U2 11
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0022-4804
EI 1095-8673
J9 J SURG RES
JI J. Surg. Res.
PD AUG
PY 2014
VL 190
IS 2
BP 683
EP 691
DI 10.1016/j.jss.2014.01.020
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA AM4DD
UT WOS:000339801800045
PM 24655666
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Fatima, N
   Faisal, SM
   Zubair, S
   Siddiqui, SS
   Moin, S
   Owais, M
AF Fatima, Naureen
   Faisal, Syed Mohd
   Zubair, Swaleha
   Siddiqui, Sheelu Shafiq
   Moin, Shagufta
   Owais, Mohammad
TI Emerging role of Interleukins IL-23/IL-17 axis and biochemical markers
   in the pathogenesis of Type 2 Diabetes: Association with age and gender
   in human subjects
SO INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
LA English
DT Article
DE Pro-inflammatory cytokines; Oxidative stress; Nitric oxide
ID NECROSIS-FACTOR-ALPHA; OXIDATIVE STRESS; INFLAMMATORY CYTOKINES;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; POSTMENOPAUSAL WOMEN; GLYCEMIC
   CONTROL; ELEVATED LEVELS; PLASMA; MELLITUS
AB Chronic hyperglycaemia in type 2 diabetes (T2D) is associated with increased oxidative stress and inflammation. Keeping the above fact into consideration we analyse the effect of age and gender on oxidative stress biomarkers and pro-inflammatory cytokines in T2D patients. The study included 148 diabetic and 110 healthy subjects, grouped on the basis of age and gender. Plasma malondialdehyde, protein carbonyl content and nitric oxide levels were elevated significantly in diabetic patients, with significant decrease in Ferric reducing ability of plasma, vitamin C, reduced glutathione, erythrocyte thiol groups and erythrocyte antioxidant enzyme activity and these changes were even more pronounced as age progressed. Serum IL-1 beta, IL-6, IL-17A, IL-22 levels and TNF-alpha mRNA expression was significantly upregulated in all the age groups whereas IL-23 mRNA was upregulated only in the higher age group. Female diabetic patients experienced higher oxidative stress and greater serum IL-6 levels and TNF-alpha mRNA expression as compared to their male counterparts. This study suggested that diabetes onset is accompanied with increased oxidative stress and elevated levels of inflammatory mediators. The effect was more prominent in aged patients. Female patients experienced greater oxidative stress as compared to males of those age groups with slightly higher levels of inflammatory cytokines. (C) 2017 Elsevier B.V. All rights reserved.
C1 [Fatima, Naureen; Moin, Shagufta] Aligarh Muslim Univ, Jawaharlal Nehru Med Coll, Dept Biochem, Aligarh 202002, Uttar Pradesh, India.
   [Faisal, Syed Mohd; Owais, Mohammad] Aligarh Muslim Univ, Interdisciplinary Biotechnol Unit, Mol Immunol Lab, Aligarh 202002, Uttar Pradesh, India.
   [Zubair, Swaleha] Aligarh Muslim Univ, Womens Coll, Aligarh 202002, Uttar Pradesh, India.
   [Siddiqui, Sheelu Shafiq] Aligarh Muslim Univ, Rajiv Gandhi Ctr Diabet & Endocrinol, Aligarh 202002, Uttar Pradesh, India.
C3 Aligarh Muslim University; Aligarh Muslim University; Aligarh Muslim
   University; Aligarh Muslim University
RP Owais, M (corresponding author), Aligarh Muslim Univ, Interdisciplinary Biotechnol Unit, Mol Immunol Lab, Aligarh 202002, Uttar Pradesh, India.
EM owais_lakhnawi@yahoo.com
RI Faisal, Syed/AAM-7496-2020; Fatima, Naureen/AFK-6203-2022; Syed, M.
   Faisal/F-2991-2014
OI Mohammad, Owais/0000-0001-7377-7388; Fatima,
   Naureen/0000-0002-7839-8827; Syed, M. Faisal/0000-0002-3968-7810
FU Department of Biotechnology, Govt. of India [DBT/2014/AMU/119]
FX We are thankful to the Co-ordinator of Interdisciplinary Biotechnology
   Unit and Chairman of the Department of Biochemistry, Jawaharlal Nehru
   Medical College, Aligarh Muslim University for allowing us to availed
   institute's research facilities. We are also grateful to the Director of
   Rajiv Gandhi Centre for Diabetes and Endocrinology, for allowing us to
   collect diabetic patient's blood. We are thankful to Dr. Fareed Ahmad,
   (Klinikfur Immunologie and Rheumatologie, Medizinische Hochschule
   Hannover, Germany) for his help in critical reading, editing and
   language assistance of the manuscript. Syed Mohd Faisal is thankful to
   Department of Biotechnology, Govt. of India for granting Senior Research
   Fellowship (DBT/2014/AMU/119).
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NR 71
TC 28
Z9 28
U1 0
U2 8
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0141-8130
EI 1879-0003
J9 INT J BIOL MACROMOL
JI Int. J. Biol. Macromol.
PD DEC
PY 2017
VL 105
BP 1279
EP 1288
DI 10.1016/j.ijbiomac.2017.07.155
PN 1
PG 10
WC Biochemistry & Molecular Biology; Chemistry, Applied; Polymer Science
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry; Polymer Science
GA FM3CW
UT WOS:000414882900143
PM 28757426
DA 2025-06-11
ER

PT J
AU Abu Bakar, MH
   Khalid, MSFM
   Shahril, NSN
   Shariff, KA
   Karunakaran, T
AF Abu Bakar, Mohamad Hafizi
   Mohamad Khalid, Mohamad Shamil Faris
   Nor Shahril, Nor Shafiqah
   Shariff, Khairul Anuar
   Karunakaran, Thiruventhan
TI Celastrol attenuates high-fructose diet-induced inflammation and insulin
   resistance via inhibition of 11β-hydroxysteroid dehydrogenase type 1
   activity in rat adipose tissues
SO BIOFACTORS
LA English
DT Article
DE adipose tissue; celastrol; high fructose diet; metabolic syndromes; 11
   beta-hydroxysteroid dehydrogenase type 1
ID MITOCHONDRIAL DYSFUNCTION; METABOLIC SYNDROME; MINERALOCORTICOID
   RECEPTOR; GLUCOCORTICOID-RECEPTOR; 11-BETA-HSD1 EXPRESSION; VISCERAL
   ADIPOSITY; 3T3-L1 ADIPOCYTES; OXIDATIVE STRESS; UP-REGULATION;
   MUSCLE-CELLS
AB High fructose consumption has been linked to low-grade inflammation and insulin resistance that results in increased intracellular 11ss-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1) activity. Celastrol, a pentacyclic triterpene, has been demonstrated to exhibit multifaceted targets to attenuate various metabolic diseases associated with inflammation. However, the underlying mechanisms by which celastrol exerts its attributive properties on high fructose diet (HFrD)-induced metabolic syndrome remain elusive. Herein, the present study was aimed to elucidate the mechanistic targets of celastrol co-administrations upon HFrD in rats and evaluate its potential to modulate 11 beta-HSD1 activity. Celastrol remarkably improved glucose tolerance, lipid profiles, and insulin sensitivity along with suppression of hepatic glucose production. In rat adipose tissues, celastrol attenuated nuclear factor-kappa B (NF-kappa B)-driven inflammation, reduced c-Jun N-terminal kinases (JNK) phosphorylation, and mitigated oxidative stress via upregulated genes expression involved in mitochondrial biogenesis. Furthermore, insulin signaling pathways were significantly improved through the restoration of Akt phosphorylation levels at Ser473 and Thr308 residues. Celastrol exhibited a potent, selective and specific inhibitor of intracellular 11 beta-HSD1 towards oxidoreductase activity (IC50 value = 4.3 nM) in comparison to other HSD-related enzymes. Inhibition of 11 beta-HSD1 expression in rat adipose microsomes reduced the availability of its cofactor NADPH and substrate H6PDH in couple to upregulated mRNA and protein expressions of glucocorticoid receptor. In conclusion, our results underscore the most likely conceivable mechanisms exhibited by celastrol against HFrD-induced metabolic dysregulations mainly through attenuating inflammation and insulin resistance, at least via specific inhibitions on 11 beta-HSD1 activity in adipose tissues.
C1 [Abu Bakar, Mohamad Hafizi; Mohamad Khalid, Mohamad Shamil Faris; Nor Shahril, Nor Shafiqah] Univ Sains Malaysia, Sch Ind Technol, Bioproc Technol Div, Gelugor 11800, Penang, Malaysia.
   [Shariff, Khairul Anuar] Univ Sains Malaysia, Sch Mat & Mineral Resources Engn, Nibong Tebal 14300, Penang, Malaysia.
   [Karunakaran, Thiruventhan] Univ Sains Malaysia, Ctr Drug Res, Gelugor 11800, Penang, Malaysia.
C3 Universiti Sains Malaysia; Universiti Sains Malaysia; Universiti Sains
   Malaysia
RP Abu Bakar, MH (corresponding author), Univ Sains Malaysia, Sch Ind Technol, Bioproc Technol Div, Gelugor 11800, Penang, Malaysia.
EM mhafizi88@usm.my
RI Karunakaran, Thiruventhan/Q-1435-2018; Abu Bakar, Mohamad
   Hafizi/O-4454-2016; Shariff, Khairul Anuar/G-6625-2016
OI Abu Bakar, Mohamad Hafizi/0000-0001-8064-695X; Shariff, Khairul
   Anuar/0000-0003-3331-2505
FU Fundamental Research Grant Scheme (FRGS), Ministry of Higher Education,
   Malaysia [FRGS/1/2019/SKK08/USM/02/1]; TWASCOMSTECH Joint Research Grant
   [18-420 RG/PHA/AS_C]; Ministry of Higher Education [SKK08]
FX Fundamental Research Grant Scheme (FRGS), Ministry of Higher Education,
   Malaysia, Grant/Award Number: FRGS/1/2019/SKK08/USM/02/1; TWASCOMSTECH
   Joint Research Grant, Grant/Award Number: 18-420 RG/PHA/AS_C; Ministry
   of Higher Education, Grant/Award Number: SKK08
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NR 74
TC 10
Z9 10
U1 0
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0951-6433
EI 1872-8081
J9 BIOFACTORS
JI Biofactors
PD JAN
PY 2022
VL 48
IS 1
BP 111
EP 134
DI 10.1002/biof.1793
EA OCT 2021
PG 24
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA YS2VL
UT WOS:000709613900001
PM 34676604
DA 2025-06-11
ER

PT J
AU Carpentieri, AR
   Lopez, MEP
   Aguilar, J
   Solá, VM
AF Rita Carpentieri, Agata
   Peralta Lopez, Maria Elena
   Aguilar, Javier
   Mariana Sola, Veronica
TI Melatonin and periodontal tissues: Molecular and clinical perspectives
SO PHARMACOLOGICAL RESEARCH
LA English
DT Review
DE Melatonin; Periodontitis; Diabetes mellitus; Psychiatric disorders
ID MESENCHYMAL STEM-CELLS; OSTEOBLAST DIFFERENTIATION; OSTEOCLAST
   DIFFERENTIATION; SIGNAL-TRANSDUCTION; SALIVARY MELATONIN; GLYCEMIC
   CONTROL; BONE LOSS; RECEPTORS; HEALTH; ASSOCIATION
AB Periodontal disease is a frequent chronic inflammatory pathology that implies the destruction of the tissues supporting the teeth, which represents a high sanitary cost. It usually appears associated with other systemic conditions such as diabetes, metabolic syndrome, depression and Alzheimer disease among others. The presence of melatonin and its receptors in the oral cavity supports the hypothesis that this hormone could play a role in homeostasis of periodontal tissues. In the present review we will discuss the potential role of melatonin, a circadian synchronizing hormone, with proved antiinflammatory and antioxidant profile, in the pathogenesis and treatment of periodontitis. Particular emphasis will be placed on the role of the indolamine in the treatment of periodontal disease when this oral condition is comorbid with other pathologies that would also benefit from the therapeutic potential of melatonin and its analogs through diverse mechanisms. (C) 2017 Elsevier Ltd. All rights reserved.
C1 [Rita Carpentieri, Agata; Peralta Lopez, Maria Elena; Mariana Sola, Veronica] Univ Nacl Cordoba, Fac Odontol, Catedra Quim Biol B, Cordoba, Argentina.
   [Rita Carpentieri, Agata] INICSA UNC CONICET, Enrique Barros Esquina Enfermera Gordillo, Ciudad Univ, Cordoba, Argentina.
   [Peralta Lopez, Maria Elena] UNC, Fac Ciencias Med, Hosp San Roque, Catedra Clin Med 2, Cordoba, Argentina.
   [Aguilar, Javier] UNC, Fac Ciencias Med, Inst Dr Jose M Venella, Cordoba, Argentina.
   [Aguilar, Javier] UNC, Fac Odontol, Catedra Introducc Fis & Quim Biol B, Cordoba, Argentina.
C3 National University of Cordoba; National University of Cordoba; National
   University of Cordoba; National University of Cordoba
RP Carpentieri, AR (corresponding author), Univ Nacl Cordoba, Fac Odontol, Catedra Quim Biol B, Cordoba, Argentina.; Carpentieri, AR (corresponding author), INICSA UNC CONICET, Enrique Barros Esquina Enfermera Gordillo, Ciudad Univ, Cordoba, Argentina.
EM arcarpentieri@hotmail.com
RI Crespo-Lopez, Maria/X-7912-2018; Sola, Veronica/IRZ-0436-2023; Agata,
   Carpentieri/AAE-4504-2022
OI Carpentieri, Agata/0000-0002-6426-0501; Sola, Veronica
   Mariana/0000-0001-8911-0342
FU SeCyT-UNC, Argentina; SeCyT-UNC
FX This work was supported by grants from SeCyT-UNC (2016-2017), Argentina.
   Prof. Dr. Agata Carpentieri is Members of Investigator Career from the
   Consejo Nacional de Investigaciones Cientificas y Tecnologicas
   (CONICET). Od. Veronica Sold was recipient of a Fellowship from
   SeCyT-UNC.
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NR 93
TC 19
Z9 20
U1 0
U2 25
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 1043-6618
J9 PHARMACOL RES
JI Pharmacol. Res.
PD NOV
PY 2017
VL 125
BP 224
EP 231
DI 10.1016/j.phrs.2017.09.003
PN B
PG 8
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA FL3GH
UT WOS:000414110400012
PM 28918172
OA Green Published
DA 2025-06-11
ER

PT J
AU Badawy, Y
   Aljohani, NH
   Salem, GA
   Ashour, FM
   Own, SA
   Alajrafi, NF
AF Badawy, Yousria
   Aljohani, Nouf H.
   Salem, Gufran A.
   Ashour, Fatima M.
   Own, Sarah A.
   Alajrafi, Nora F.
TI Predictability of the Development of Insulin Resistance Based on the
   Risk Factors Among Female Medical Students at a Private College in Saudi
   Arabia
SO CUREUS JOURNAL OF MEDICAL SCIENCE
LA English
DT Article
DE body weight; risk factors; day sleep; daily physical activity; diastolic
   blood pressure; systolic blood pressure; obesity; life style habits;
   body mass index; insulin resistance
ID METABOLIC SYNDROME; WAIST CIRCUMFERENCE; PHYSICAL-ACTIVITY; OBESITY;
   ASSOCIATION; FAT
AB Background: Insulin resistance (IR) is currently an underlying phenomenon in the etiology of most non -communicable diseases. IR has been proposed as the key linking factor for the metabolic syndrome disease cluster of glucose intolerance. Objectives: This study's target was to assess the predictability of risk factors for IR among female medical students Methods: A cross-sectional study involving female medical students was carried out. The sample size was 272, and a suitable non-probability sampling method was employed. A correlation test was done, and a P value less than 0.05 is considered statistically significant. Each participant underwent assessment of anthropometric measurements and biochemical testing. For assessing lifestyle, validated questionnaires on physical activity, sleep pattern, dietary pattern, and stress were adopted. The anthropometric data such as height, weight, and waist circumference were collected. Biochemical testing involved estimation of the postprandial capillary blood glucose level on campus. Additionally, systolic blood pressure and diastolic blood pressure were measured. Results: The association of lifestyle risk factors with waist circumference as an indicator of IR was done where the majority of those with high waist circumference were physically inactive and more prone to stress which was statistically significant when compared to those with normal waist circumference. However, poor sleep and unhealthy diet were high among those with high waist circumference, but they were not statistically significant. Conclusion: The correlation of waist circumference as an indicator of IR was highly significant with body mass index, postprandial blood sugar, systolic blood pressure, and diastolic blood pressure. A series of unhealthy lifestyle habits was contributable to developing obesity and therefore IR among medical students in Saudi Arabia.
C1 [Badawy, Yousria] Alexandria Univ, Family & Community Med, Alexandria, Egypt.
   [Badawy, Yousria] Ibn Sina Natl Coll Med Studies, Family Med, Jeddah, Saudi Arabia.
   [Aljohani, Nouf H.; Salem, Gufran A.; Ashour, Fatima M.; Own, Sarah A.; Alajrafi, Nora F.] Ibn Sina Natl Coll Med Studies, Med, Jeddah, Saudi Arabia.
C3 Egyptian Knowledge Bank (EKB); Alexandria University; Ibn Sina National
   College for Medical Studies; Ibn Sina National College for Medical
   Studies
RP Badawy, Y (corresponding author), Alexandria Univ, Family & Community Med, Alexandria, Egypt.; Badawy, Y (corresponding author), Ibn Sina Natl Coll Med Studies, Family Med, Jeddah, Saudi Arabia.
EM yousriabadawy@gmail.com
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NR 35
TC 2
Z9 2
U1 1
U2 1
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
EI 2168-8184
J9 CUREUS J MED SCIENCE
JI Cureus J Med Sci
PD MAY 16
PY 2023
VL 15
IS 5
DI 10.7759/cureus.39112
PG 11
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA J5DD0
UT WOS:001009812400031
PM 37378117
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Mularczyk, M
   Bourebaba, Y
   Kowalczuk, A
   Marycz, K
   Bourebaba, L
AF Mularczyk, Malwina
   Bourebaba, Yasmina
   Kowalczuk, Anna
   Marycz, Krzyzstof
   Bourebaba, Lynda
TI Probiotics-rich emulsion improves insulin signalling in
   Palmitate/Oleate-challenged human hepatocarcinoma cells through the
   modulation of Fetuin-A/TLR4-JNK-NF-κB
   pathway
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Article
DE Probiotics; Insulin resistance; Lipotoxicity; Mitochondrial dysfunction;
   Fetuin-A; TLR4
ID FATTY LIVER-DISEASE; STROMAL STEM-CELLS; FETUIN-A CONCENTRATIONS;
   METABOLIC SYNDROME; GUT MICROBIOTA; OXIDATIVE STRESS; DIABETES-MELLITUS;
   RESISTANCE; OBESITY; ACCUMULATION
AB Background: Fetuin-A, also known as alpha 2-Heremans-Schmid glycoprotein (AHSG), is an abundant plasmatic serum protein synthesized predominantly in liver and adipose tissue. This glycoprotein is known to negatively regulate insulin signaling through the inhibition of insulin receptor (IR) autophosphorylation and tyrosine kinase activity, which participates in insulin resistance (IR) and metabolic syndrome development. Recent studies demonstrated that IR and associated metabolic disorders, are closely related to the gut microbiota and modulating it by probiotics could be effective in metabolic diseases management.
   Objective: In this present work we aimed to evaluate the effects of a probiotics-rich emulsion on reducing the IR induced by free fatty acids accumulation in human hepatocarcinoma cell line, and to elucidate the implicated molecular pathways, with a specific emphasis on the hepatokin Fetuin-A-related axis.
   Results: Here we showed, that probiotics improve HepG2 viability, protect against apoptosis under normal and IR conditions. Moreover, the emulsion was successful in attenuating oxidative stress as well as improving mitochondria) metabolism and dynamics. Interestingly, application of the probiotics to lipotoxic HepG2 cells resulted in significant reduction of Fetuin-A/TLR4/JNK/NF-kappa B pathway activation, which suggests a protective effect against inflammation, obesity as well as liver related insulin resistant.
   Conclusion: Overall, the presented data reports clearly on the potent potential of probiotics formulated in an emulsion vehicle to enhance metabolic functions of affected IR HepG2 cells, and suggest the possibility of using such preparations as insulin sensitizing therapy, playing at the same time protective role for the development of liver related insulin resistant.
C1 [Mularczyk, Malwina; Marycz, Krzyzstof; Bourebaba, Lynda] Wroclaw Univ Environm & Life Sci, Fac Biol & Anim Sci, Dept Expt Biol, Norwida 27B, PL-50375 Wroclaw, Poland.
   [Mularczyk, Malwina; Bourebaba, Yasmina; Marycz, Krzyzstof; Bourebaba, Lynda] Int Inst Translat Med, Jesionowa 11, PL-55114 Malin, Wisznia Mala, Poland.
   [Bourebaba, Yasmina] Univ Bejaia, Fac Sci Nat & Vie, Dept Tronc Commun, Bejaia 06000, Algeria.
   [Kowalczuk, Anna] Natl Med Inst, Chelmska 30-34, PL-00725 Warsaw, Poland.
C3 Wroclaw University of Environmental & Life Sciences; Universite de
   Bejaia; National Medicines Institute Lekow (NIL)
RP Bourebaba, L (corresponding author), Wroclaw Univ Environm & Life Sci, Fac Biol & Anim Sci, Dept Expt Biol, Norwida 27B, PL-50375 Wroclaw, Poland.
EM lynda.bourebaba@upwr.edu.pl
RI Bourebaba, Lynda/AAX-7613-2020; Bourebaba, Yasmina/AAZ-9627-2021
FU National Science Centre in Poland [2018/29/B/NZ7/02662]; Uniwersytet
   Przyrodniczy we Wrocawiu e [B030/0039/20]
FX The work was supported by grant from National Science Centre in Poland
   over the course of the realization of the project: 'Inhibition of
   tyrosine phosphatase as a strategy to enhance insulin sensitivity
   through activation of chaperone mediated autophagy and amelioration of
   inflammation and cellular stress in the liver of equine metabolic
   syndrome (EMS) horses' (2018/29/B/NZ7/02662) . The study was also funded
   by grant obtained from Uniwersytet Przyrodniczy we Wrocawiu entitled
   "Identification of FetuinA protein in different equine tissues and sera
   and its correlation with equine metabolic syndrome" (B030/0039/20) .
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NR 86
TC 18
Z9 18
U1 4
U2 40
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD JUL
PY 2021
VL 139
AR 111560
DI 10.1016/j.biopha.2021.111560
EA APR 2021
PG 18
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA SV2UY
UT WOS:000663680800005
PM 33839491
OA gold
DA 2025-06-11
ER

PT J
AU Yoshino, S
   Hamasaki, S
   Ishida, S
   Kataoka, T
   Yoshikawa, A
   Oketani, N
   Saihara, K
   Okui, H
   Shinsato, T
   Ichiki, H
   Kubozono, T
   Kuwahata, S
   Fujita, S
   Kanda, D
   Nakazaki, M
   Miyata, M
   Tei, C
AF Yoshino, Satoshi
   Hamasaki, Shuichi
   Ishida, Sanemasa
   Kataoka, Tetsuro
   Yoshikawa, Akiko
   Oketani, Naoya
   Saihara, Keishi
   Okui, Hideki
   Shinsato, Takuro
   Ichiki, Hitoshi
   Kubozono, Takuro
   Kuwahata, So
   Fujita, Shoji
   Kanda, Daisuke
   Nakazaki, Mitsuhiro
   Miyata, Masaaki
   Tei, Chuwa
TI Relationship Between Bilirubin Concentration, Coronary Endothelial
   Function, and Inflammatory Stress in Overweight Patients
SO JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
LA English
DT Article
DE Bilirubin; Endothelial dysfunction; Coronary artery; Inflammatory stress
ID C-REACTIVE PROTEIN; LOW-DENSITY-LIPOPROTEIN; ISCHEMIC-HEART-DISEASE;
   SERUM BILIRUBIN; BILIVERDIN REDUCTASE; METABOLIC SYNDROME; CAROTID
   ATHEROSCLEROSIS; INSULIN-RESISTANCE; ARTERY-DISEASE; YOUNG-ADULTS
AB Aim: Bilirubin has antioxidant properties and may protect against atherosclerosis and coronary heart disease (CHD). Further, in patients with metabolic syndrome, hyperbilirubinemia is associated with attenuation of insulin resistance. The aim of the present study was to determine the relationship between serum bilirubin concentration and coronary endothelial function in overweight patients.
   Methods: The study population consisted of 107 patients without CHD who underwent coronary flow studies. Vascular reactivity was examined by intra-coronary administration of papaverine and nitroglycerin. Coronary endothelial function was evaluated by assessing the change in coronary artery diameter to papaverine [percent change in flow-mediated dilatation (%FMD)] and nitroglycerin (%NTG). Serum total bilirubin, high-sensitivity C-reactive protein (hs-CRP), high density lipoprotein-cholesterol (HDL-C), fasting plasma glucose and immunoreactive insulin levels were also measured, and the homeostasis model assessment insulin resistance (HOMA-IR) index was calculated. Patients were divided into two groups according to body mass index (BMI): an overweight group (BMI >= 25; n = 36) and a normal weight group (BMI <25; n = 71).
   Results: In the overweight group, univariate analysis revealed that log-transformed total bilirubin was positively correlated with %FMD and HDL-C (r = 0.38, p<0.05; r = 0.30, p<0.05, respectively) and was inversely correlated with log-transformed hs-CRP and HOMA-IR (r = -0.45, p<0.01; r = -0.45, p<0.05, respectively). Multivariate analysis revealed that log-transformed hs-CRP was the only independent predictor of log-transformed total bilirubin (p<0.05).
   Conclusions: These results suggest that a high bilirubin level was associated with favorable coronary endothelial function in overweight patients. Further, the anti-inflammatory effects of bilirubin may mediate this effect.
C1 [Yoshino, Satoshi; Hamasaki, Shuichi; Ishida, Sanemasa; Kataoka, Tetsuro; Yoshikawa, Akiko; Oketani, Naoya; Saihara, Keishi; Okui, Hideki; Shinsato, Takuro; Ichiki, Hitoshi; Kubozono, Takuro; Kuwahata, So; Fujita, Shoji; Kanda, Daisuke; Nakazaki, Mitsuhiro; Miyata, Masaaki; Tei, Chuwa] Kagoshima Univ, Grad Sch Med, Dept Cardiovasc Resp & Metab Med, Kagoshima 8908520, Japan.
C3 Kagoshima University
RP Hamasaki, S (corresponding author), Kagoshima Univ, Grad Sch Med, Dept Cardiovasc Resp & Metab Med, 8-35-1 Sakuragaoka, Kagoshima 8908520, Japan.
EM hamasksh@m.kufm.kagoshima-u.ac.jp
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NR 47
TC 43
Z9 48
U1 0
U2 8
PU JAPAN ATHEROSCLEROSIS SOC
PI TOKYO
PA NICHINAI-KAIKAN B1, 3-28-8 HONGO BUNKYO-KU, TOKYO, 113-0033, JAPAN
SN 1340-3478
EI 1880-3873
J9 J ATHEROSCLER THROMB
JI J. Atheroscler. Thromb.
PY 2011
VL 18
IS 5
BP 403
EP 412
DI 10.5551/jat.6346
PG 10
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 770RJ
UT WOS:000291105900007
PM 21350306
OA hybrid
DA 2025-06-11
ER

PT J
AU El Mesallamy, HO
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   Hammad, Lamiaa N.
   El Magdoub, Hekmat M.
TI Effect of taurine supplementation on hyperhomocysteinemia and markers of
   oxidative stress in high fructose diet induced insulin resistance
SO DIABETOLOGY & METABOLIC SYNDROME
LA English
DT Article
ID METABOLIC SYNDROME; GLUCOSE-METABOLISM; NITRIC-OXIDE; HOMOCYSTEINE; RAT;
   MECHANISMS; PRECIPITATION; CHOLESTEROL; CONSUMPTION; HOMEOSTASIS
AB Background: High intake of dietary fructose is accused of being responsible for the development of the insulin resistance (IR) syndrome. Concern has arisen because of the realization that fructose, at elevated concentrations, can promote metabolic changes that are potentially deleterious. Among these changes is IR which manifests as a decreased biological response to normal levels of plasma insulin.
   Methods: Oral glucose tolerance tests (OGTT) were carried out, homeostasis model assessment of insulin resistance (HOMA) was calculated, homocysteine (Hcy), lipid concentrations and markers of oxidative stress were measured in male Wistar rats weighing 170-190 g. The rats were divided into four groups, kept on either control diet or high fructose diet (HFD), and simultaneously supplemented with 300 mg/kg/day taurine via intra-peritoneal (i.p.) route for 35 days.
   Results: Fructose-fed rats showed significantly impaired glucose tolerance, impaired insulin sensitivity, hypertriglyceridemia, hypercholesterolemia, hyperhomocysteinemia (HHcy), lower total antioxidant capacity (TAC), lower paraoxonase (PON) activity, and higher nitric oxide metabolites (NOx) concentration, when compared to rats fed on control diet. Supplementing the fructose-fed rats with taurine has ameliorated the rise in HOMA by 56%, triglycerides (TGs) by 22.5%, total cholesterol (T-Chol) by 11%, and low density lipoprotein cholesterol (LDL-C) by 21.4%. Taurine also abolished any significant difference of TAC, PON activity and NOx concentration among treated and control groups. TAC positively correlated with PON in both rats fed on the HFD and those received taurine in addition to the HFD. Fructose-fed rats showed 34.7% increase in Hcy level. Taurine administration failed to prevent the observed HHcy in the current dosage and duration.
   Conclusion: Our results indicate that HFD could induce IR which could further result in metabolic syndrome (MS), and that taurine has a protective role against the metabolic abnormalities induced by this diet model except for HHcy.
C1 [Hammad, Lamiaa N.; El Magdoub, Hekmat M.] Misr Int Univ, Fac Pharm, Dept Biochem, Cairo, Egypt.
   [El Mesallamy, Hala O.] Ain Shams Univ, Fac Pharm, Dept Biochem, Cairo, Egypt.
   [El-Demerdash, Ebtehal] Ain Shams Univ, Fac Pharm, Dept Biochem, Dept Pharmacol & Toxicol, Cairo, Egypt.
C3 Egyptian Knowledge Bank (EKB); Misr University for Science & Technology;
   Misr International University; Egyptian Knowledge Bank (EKB); Ain Shams
   University; Egyptian Knowledge Bank (EKB); Ain Shams University
RP El Magdoub, HM (corresponding author), Misr Int Univ, Fac Pharm, Dept Biochem, Cairo, Egypt.
EM h_elmagdoub@hotmail.com
RI Magdoub, Hekmat/ABC-7931-2020; El-Demerdash, Ebtehal/ABE-6729-2020;
   Hammad, Lamiaa/S-4925-2019
OI El Mesallamy, Hala/0000-0001-8190-536X; El Magdoub,
   Hekmat/0000-0001-5742-6713
FU "Office of Scientific Research", Misr International University, Cairo,
   Egypt
FX This work received partial financial support from the "Office of
   Scientific Research", Misr International University, Cairo, Egypt.
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NR 61
TC 47
Z9 52
U1 0
U2 4
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1758-5996
J9 DIABETOL METAB SYNDR
JI Diabetol. Metab. Syndr.
PD JUN 30
PY 2010
VL 2
AR 46
DI 10.1186/1758-5996-2-46
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 759PV
UT WOS:000290261300001
PM 20591133
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Aboeldahab, S
   El-Hamd, MA
   Bakla, RMH
   Nada, EAA
AF Aboeldahab, Soha
   El-Hamd, Mohammed A.
   Bakla, Rehab M. Hamed
   Nada, Essam Abdel-Aziz
TI Clinicodemographic and laboratory features of 200 Egyptian psoriatic
   patients
SO EGYPTIAN JOURNAL OF DERMATOLOGY AND VENEREOLOGY
LA English
DT Article
DE clinical; demographic; psoriasis
ID METABOLIC SYNDROME; PREVALENCE; EPIDEMIOLOGY; SEVERITY; DISEASE; IMPACT;
   ONSET; RISK
AB Background Psoriasis is a common and complex multifactorial disease, in which both genetic and extrinsic factors contribute to activating an immunological reaction. Objectives This study aimed to evaluate the clinical, demographic, and laboratory characteristics of Egyptian psoriatic patients in Sohag, Upper Egypt. Patients and methods This study was a cross-sectional hospital-based study conducted on 200 Egyptian psoriatic patients. All the patients were subjected to complete demographic, clinical, and laboratory evaluations. Results Of the 200 Egyptian patients with psoriasis, the mean age was 42.83 +/- 17.3 years; 60% were males, 53% were from rural areas, 47% were smokers, 66% were with positive family history, 91% were with gradual onset, 75% were with a progressive course, and 6.99 +/- 3.9 months was the mean duration of the diseases. The main associated symptom with psoriasis was itching in 72%. Psoriasis vulgaris was the most common type in 69.5%. Upper limbs were the most commonly affected sites in 78% of the psoriatic patients. Seasonal variation was the most common exacerbating factor in 51.5% of psoriatic patients. Iron-deficiency anemia was detected in 31% of the psoriatic patients. Liver diseases were associated comorbidities with 29.5% of psoriatic patients and hepatitis C virus infection was presented in 4.5% of psoriatic patients. Metabolic syndrome and stress were detected in 36 and 21% of psoriatic patients, respectively. Conclusion The healthcare providers and patients should be aware of the early detection of associated comorbidities with psoriasis to avoid major complications. The recognition of stress and its specific treatment should be considered an integral part of the treatment of psoriatic patients. Screening for hepatitis is important in Egyptian psoriatic patients. Consanguineous marriage should be avoided in patients with a family history of psoriasis.
C1 [Aboeldahab, Soha; El-Hamd, Mohammed A.; Bakla, Rehab M. Hamed; Nada, Essam Abdel-Aziz] Sohag Univ, Fac Med, Dept Dermatol Venereol Androl, Sohag Univ St, Sohag 82524, Egypt.
C3 Egyptian Knowledge Bank (EKB); Sohag University
RP El-Hamd, MA (corresponding author), Sohag Univ, Fac Med, Dept Dermatol Venereol Androl, Sohag Univ St, Sohag 82524, Egypt.
EM mohammedadva@yahoo.com
RI Nada, Essam/H-8586-2019; Abu El-Hamd, Mohammed/J-3469-2019
OI Abu El-Hamd, Mohammed/0000-0002-0100-624X
CR Affandi AM, 2018, DERMAT RES PRACT, V2018, DOI 10.1155/2018/4371471
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NR 33
TC 0
Z9 0
U1 0
U2 2
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, Maharashtra, INDIA
SN 1110-6530
EI 2314-7407
J9 EGYPT J DERMAT VENER
JI Egypt. J. Dermat. Vener.
PD JAN-APR
PY 2023
VL 43
IS 1
BP 15
EP 23
DI 10.4103/ejdv.ejdv_9_22
PG 9
WC Dermatology
WE Emerging Sources Citation Index (ESCI)
SC Dermatology
GA 8W1UO
UT WOS:000931106400003
DA 2025-06-11
ER

PT J
AU Kim, JH
   Baik, HW
   Yoon, YS
   Joung, HJ
   Park, JS
   Park, SJ
   Jang, EJ
   Park, SW
   Kim, SJ
   Kim, MJ
   Jeon, DO
   Cho, HJ
   Lee, SJ
   Im, SG
   Jang, SK
AF Kim, Jung Hee
   Baik, Hyun Wook
   Yoon, Yeong Sook
   Joung, Hyo Jee
   Park, Ju Sang
   Park, Sang Jong
   Jang, Eun Jeong
   Park, Sang Woon
   Kim, Sang Jung
   Kim, Mi Jeoung
   Jeon, Dong Ok
   Cho, Hyo Jin
   Lee, Sang Jin
   Im, Sung Gyu
   Jang, Sun Kyung
TI Measurement of antioxidant capacity using the biological antioxidant
   potential test and its role as a predictive marker of metabolic syndrome
SO KOREAN JOURNAL OF INTERNAL MEDICINE
LA English
DT Article
ID NECROSIS-FACTOR-ALPHA; C-REACTIVE PROTEIN; NUTRITION EXAMINATION SURVEY;
   INCREASED OXIDATIVE STRESS; DENSITY-LIPOPROTEIN; NATIONAL-HEALTH;
   IN-VIVO; ADULTS; INFLAMMATION; ADIPONECTIN
AB Background/Aims: Oxidative stress increases the risk of cardiovascular complications of metabolic syndrome (MetS). This study was conducted to examine the difference in antioxidant capacity according to the presence of MetS, and to characterize the association between antioxidant capacity and MetS-related factors.
   Methods: We used the biological antioxidant potential (BAP) test to estimate antioxidant capacity. The BAP test has recently been used as an indicator of antioxidant capacity. We measured BAP levels in 45 patients with MetS (mean age, 44.6 +/- 1.1 years) and 47 age- and sex-matched controls (mean age, 42.7 +/- 1.1 years). To evaluate the association between antioxidant capacity and MetS, adiponectin, high-sensitivity C-reactive protein (hs-CRP), interleukin-6, tumor necrosis factor-alpha, and homeostatic model assessment for insulin resistance (HOMA-IR), linear regression and logistic analyses were performed.
   Results: The mean BAP of the MetS group (1,937.3 +/- 36.5 mu mol/L) was significantly lower than that of the non-MetS group (2,101.7 +/- 29.5 mu mol/L). Also, the mean BAP was low in persons having low high density lipoprotein and high triglyceride. Reduced antioxidant capacity was significantly associated with adiponectin, HOMA-IR and hs-CRP after adjusting for age and sex. The odds ratios for MetS with BAP, log adiponectin, log HOMA-IR, and log hs-CRP were 0.63 (95% confidence interval [CI], 0.49 to 0.82), 0.22 (0.10 to 0.51), 14.24 (4.35 to 46.58), and 1.93 (1.36 to 2.75), respectively.
   Conclusions: Persons with MetS showed reduced antioxidant capacity. We identified relationships between antioxidant capacity measured by BAP test and MetS, as well as MetS-related factors, such as insulin resistance, hs-CRP, and adiponectin.
C1 [Kim, Jung Hee; Baik, Hyun Wook; Park, Ju Sang; Park, Sang Jong; Jang, Eun Jeong; Park, Sang Woon; Kim, Sang Jung; Kim, Mi Jeoung; Jeon, Dong Ok; Cho, Hyo Jin; Lee, Sang Jin; Im, Sung Gyu; Jang, Sun Kyung] Bundang Jesaeng Hosp, Dept Internal Med, Songnam 463774, South Korea.
   [Yoon, Yeong Sook] Inje Univ, Ilsan Paik Hosp, Dept Family Med, Goyang, South Korea.
   [Yoon, Yeong Sook] Seoul Natl Univ, Grad Sch Publ Hlth, Seoul, South Korea.
C3 Inje University; Seoul National University (SNU)
RP Baik, HW (corresponding author), Bundang Jesaeng Hosp, Dept Internal Med, 20 Seohyeon Ro,18Obeon Gil, Songnam 463774, South Korea.
EM hbaik@dmc.or.kr
RI Joung, Hyojee/AAU-9502-2020; Kim, Jung/AAG-1191-2019; Park,
   Sang-Jong/B-7049-2011
OI Kim, Jung Hee/0000-0003-1932-0234; Kim, Sang-Jung/0000-0002-2530-5906;
   Yoon, Yeong Sook/0000-0002-9249-2940
FU Research Cooperating Program for Agricultural Science & Technology
   Development, Rural Development Administration, Republic of Korea
   [PJ007211]
FX This study was performed with the support of the Research Cooperating
   Program for Agricultural Science & Technology Development (Project No.
   PJ007211), Rural Development Administration, Republic of Korea.
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NR 32
TC 23
Z9 23
U1 0
U2 5
PU KOREAN ASSOC INTERNAL MEDICINE
PI SEOUL
PA 101-2501 LOTTE CASTLE PRESIDENT, 109 MAPO-DAERO, MAPO-GU, SEOUL,
   121-916, SOUTH KOREA
SN 1226-3303
J9 KOREAN J INTERN MED
JI Korean J. Intern. Med.
PD JAN
PY 2014
VL 29
IS 1
BP 31
EP 39
DI 10.3904/kjim.2014.29.1.31
PG 9
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA AY7NK
UT WOS:000347746500006
PM 24574831
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Dicks, N
   Gutierrez, K
   Currin, L
   de Macedo, MP
   Glanzner, WG
   Mondadori, RG
   Michalak, M
   Agellon, LB
   Bordignon, V
AF Dicks, Naomi
   Gutierrez, Karina
   Currin, Luke
   de Macedo, Mariana P.
   Glanzner, Werner G.
   Mondadori, Rafael G.
   Michalak, Marek
   Agellon, Luis B.
   Bordignon, Vilceu
TI Tauroursodeoxycholic acid/TGR5 signaling promotes survival and early
   development of glucose-stressed porcine embryos
SO BIOLOGY OF REPRODUCTION
LA English
DT Article
DE GPBAR1; TUDCA; embryo development; UPR; ER stress
ID ENDOPLASMIC-RETICULUM-STRESS; NEGATIVE-ENERGY BALANCE; IN-VITRO
   PRODUCTION; METABOLIC SYNDROME; CONGENITAL-MALFORMATIONS; UNITED-STATES;
   ACTIVATION; FERTILITY; HYPERGLYCEMIA; PREVALENCE
AB Conditions of impaired energy and nutrient homeostasis, such as diabetes and obesity, are associated with infertility. Hyperglycemia increases endoplasmic reticulum stress as well as oxidative stress and reduces embryo development and quality. Oxidative stress also causes deoxyribonucleic acid damage, which impairs embryo quality and development. The natural bile acid tauroursodeoxycholic acid reduces endoplasmic reticulum stress and rescues developmentally incompetent late-cleaving embryos, as well as embryos subjected to nuclear stress, suggesting the endoplasmic reticulum stress response, or unfolded protein response, and the genome damage response are linked. Tauroursodeoxycholic acid acts via the Takeda-G-proteinreceptor-5 to alleviate nuclear stress in embryos. To evaluate the role of tauroursodeoxycholic acid/Takeda-G-protein-receptor-5 signaling in embryo unfolded protein response, we used a model of glucose-induced endoplasmic reticulum stress. Embryo development was impaired by direct injection of tauroursodeoxycholic acid into parthenogenetically activated oocytes, whereas it was improved when tauroursodeoxycholic acid was added to the culture medium. Attenuation of the Takeda-G-protein-receptor-5 precluded the positive effect of tauroursodeoxycholic acid supplementation on development of parthenogenetically activated and fertilized embryos cultured under standard conditions and parthenogenetically activated embryos cultured with excess glucose. Moreover, attenuation of tauroursodeoxycholic acid/Takeda-G-protein-receptor-5 signaling induced endoplasmic reticulum stress, oxidative stress and cell survival genes, but decreased expression of pluripotency genes in parthenogenetically activated embryos cultured under excess glucose conditions. These data suggest that Takeda-G-protein-receptor-5 signaling pathways link the unfolded protein response and genome damage response. Furthermore, this study identifies Takeda-G-protein-receptor-5 signaling as a potential target for mitigating fertility issues caused by nutrient excess-associated blastomere stress and embryo death.
C1 [Dicks, Naomi; Gutierrez, Karina; Currin, Luke; de Macedo, Mariana P.; Glanzner, Werner G.; Mondadori, Rafael G.; Bordignon, Vilceu] McGill Univ, Dept Anim Sci, 21,111 Lakeshore Rd, Ste Anne De Bellevue, PQ H9X 3V9, Canada.
   [Mondadori, Rafael G.] Univ Fed Pelotas, ReproPel, Pelotas, RS, Brazil.
   [Michalak, Marek] Univ Alberta, Dept Biochem, Edmonton, AB, Canada.
   [Agellon, Luis B.] McGill Univ, Sch Human Nutr, 21,111 Lakeshore Rd, Ste Anne De Bellevue, PQ H9X 3V9, Canada.
C3 McGill University; Universidade Federal de Pelotas; University of
   Alberta; McGill University
RP Bordignon, V (corresponding author), McGill Univ, Dept Anim Sci, 21,111 Lakeshore Rd, Ste Anne De Bellevue, PQ H9X 3V9, Canada.; Agellon, LB (corresponding author), McGill Univ, Sch Human Nutr, 21,111 Lakeshore Rd, Ste Anne De Bellevue, PQ H9X 3V9, Canada.
EM luis.agellon@mcgill.ca; vilceu.bordignon@mcgill.ca
RI Bordignon, Vilceu/LTE-8003-2024; Mondadori, Rafael/G-5536-2012;
   Glanzner, Werner Giehl/J-6847-2015
OI Mondadori, Rafael/0000-0003-0578-8469; Glanzner, Werner
   Giehl/0000-0001-6467-8687; Gutierrez, Karina/0000-0001-9112-1542
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NR 55
TC 11
Z9 13
U1 2
U2 25
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0006-3363
EI 1529-7268
J9 BIOL REPROD
JI Biol. Reprod.
PD JUL
PY 2021
VL 105
IS 1
BP 76
EP 86
DI 10.1093/biolre/ioab072
EA APR 2021
PG 11
WC Reproductive Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Reproductive Biology
GA TH3PN
UT WOS:000672005300008
PM 33889948
OA Green Published
DA 2025-06-11
ER

PT J
AU Ihm, SH
   Jang, SW
   Kim, OR
   Chang, K
   Oak, MH
   Lee, JO
   Lim, DY
   Kim, JH
AF Ihm, Sang-Hyun
   Jang, Sung-Won
   Kim, Ok-Ran
   Chang, Kiyuk
   Oak, Min-Ho
   Lee, Jung-Ok
   Lim, Dong-Yoon
   Kim, Jae-Hyung
TI Decaffeinated green tea extract improves hypertension and insulin
   resistance in a rat model of metabolic syndrome
SO ATHEROSCLEROSIS
LA English
DT Article
DE Green tea extract; Caffeine; Hypertension; Endothelial function; Insulin
   resistance
ID VASCULAR SMOOTH-MUSCLE; BLOOD-PRESSURE; OLETF RATS; ENDOTHELIAL
   DYSFUNCTION; EXPRESSION; CAFFEINE; INCREASES; CATECHINS; RESPONSES;
   PROTECTS
AB Background: Oxidative stress and endothelial dysfunction are closely associated with hypertension and insulin resistance (IR) in metabolic syndrome (MetS). It is still controversial whether green tea extract (GTE) may have blood pressure (BP) lowering effect. Decaffeinated GTE might be presumed to have strong antioxidative effect and BP-lowering effect as compared with catechins. Thus we investigated whether decaffeinated-GTE could attenuate hypertension and IR by improving endothelial dysfunction and reducing oxidative stress in a rat model of MetS.
   Methods and Results: 20 Otsuka Long-Evans Tokushima Fatty (OLETF) rats at 13 weeks old, MetS rats, were randomized into a saline treated group (OLETF; n = 10) and a group treated with decaffeinated-GTE (25 mg/kg/day) (GTE-OLETF; n = 10). Intraperitoneal glucose tolerance tests and BP measurements were performed at 13 and 25 weeks. Decaffeinated-GTE significantly reduced BP (OLETF vs. GTE-OLETF; 130 +/- 7 vs. 121 +/- 3 mmHg, p = 0.01), fasting/postprandial 2 h glucose (141 +/- 18/159 +/- 13 vs. 115 +/- 7/132 +/- 16 mg/dL, p = 0.009/0.002) and insulin levels (4.8 +/- 2.3 vs. 2.4 +/- 1.3 ng/mL, p < 0.001). Decaffeinated-GTE significantly reduced vascular reactive oxygen species (ROS) formation and NADPH oxidase activity, and improved endothelium dependent relaxation in the thoracic aorta of OLETF rats. Decaffeinated-GTE also suppressed the expression of p47 and p22phox (NADPH oxidase subunits) in the immunohistochemical staining, and stimulated phosphorylation of endothelial nitric oxide synthase (eNOS) and Akt in the immunoblotting of aortas.
   Conclusions: Decaffeinated-GTE reduced the formation of ROS and NADPH oxidase activity and stimulated phosphorylation of eNOS and Akt in the aorta of a rat model of MetS, which resulted in improved endothelial dysfunction and IR, and eventually lowered BP. (C) 2012 Published by Elsevier Ireland Ltd.
C1 [Ihm, Sang-Hyun; Jang, Sung-Won; Kim, Ok-Ran; Chang, Kiyuk; Kim, Jae-Hyung] Catholic Univ Korea, Coll Med, Dept Internal Med, Div Cardiol, Seoul, South Korea.
   [Oak, Min-Ho] Mokpo Natl Univ, Coll Pharm, Muan, Jeonnam, South Korea.
   [Lee, Jung-Ok] Univ Strasbourg, Fac Pharm, UMR CNRS 7213, Lab Biophoton & Pharmacol, Illkirch Graffenstaden, France.
   [Lim, Dong-Yoon] Chosun Univ, Coll Med, Dept Pharmacol, Kwangju 501759, South Korea.
C3 Catholic University of Korea; Mokpo National University; Centre National
   de la Recherche Scientifique (CNRS); CNRS - National Institute for
   Biology (INSB); Universites de Strasbourg Etablissements Associes;
   Universite de Strasbourg; Chosun University
RP Kim, JH (corresponding author), St Pauls Hosp, Seoul 130709, South Korea.
EM jhkim480@catholic.ac.kr
RI Kim, Jae-hyung/J-8504-2012; Oak, Min-Ho/AAE-7405-2020; LEE,
   HYUN/ABC-6119-2021; Jang, Sung-Won/I-1292-2017
OI Ihm, Sang Hyun/0000-0001-5017-5421
FU Institute of Clinical Medicine Research of Bucheon St. Mary's Hospital,
   Research Fund [BCMC10LA02]
FX This work was supported by the Institute of Clinical Medicine Research
   of Bucheon St. Mary's Hospital, Research Fund, BCMC10LA02.
CR Basu A, 2010, J AM COLL NUTR, V29, P31, DOI 10.1080/07315724.2010.10719814
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NR 30
TC 49
Z9 50
U1 0
U2 32
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0021-9150
J9 ATHEROSCLEROSIS
JI Atherosclerosis
PD OCT
PY 2012
VL 224
IS 2
BP 377
EP 383
DI 10.1016/j.atherosclerosis.2012.07.006
PG 7
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 012UF
UT WOS:000309261400017
PM 22877868
DA 2025-06-11
ER

PT J
AU Fitzgibbons, TP
   Kogan, S
   Aouadi, M
   Hendricks, GM
   Straubhaar, J
   Czech, MP
AF Fitzgibbons, Timothy P.
   Kogan, Sophia
   Aouadi, Myriam
   Hendricks, Greg M.
   Straubhaar, Juerg
   Czech, Michael P.
TI Similarity of mouse perivascular and brown adipose tissues and their
   resistance to diet-induced inflammation
SO AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
LA English
DT Article
DE obesity; microarray; macrophages; lipid droplet proteins; diabetes
ID PORCINE CORONARY-ARTERIES; INSULIN-RESISTANCE; CARDIOVASCULAR-DISEASE;
   METABOLIC SYNDROME; OXIDATIVE STRESS; GENE-EXPRESSION; LINKING OBESITY;
   RISK-FACTORS; PPAR-GAMMA; FAT
AB Fitzgibbons TP, Kogan S, Aouadi M, Hendricks GM, Straubhaar J, Czech MP. Similarity of mouse perivascular and brown adipose tissues and their resistance to diet-induced inflammation. Am J Physiol Heart Circ Physiol 301: H1425-H1437, 2011. First published July 15, 2011; doi: 10.1152/ajpheart.00376.2011.-Thoracic perivascular adipose tissue (PVAT) is a unique adipose depot that likely influences vascular function and susceptibility to pathogenesis in obesity and the metabolic syndrome. Surprisingly, PVAT has been reported to share characteristics of both brown and white adipose, but a detailed direct comparison to interscapular brown adipose tissue (BAT) has not been performed. Here we show by full genome DNA microarray analysis that global gene expression profiles of PVAT are virtually identical to BAT, with equally high expression of Ucp-1, Cidea, and other genes known to be uniquely or very highly expressed in BAT. PVAT and BAT also displayed nearly identical phenotypes upon immunohistochemical analysis, and electron microscopy confirmed that PVAT contained multilocular lipid droplets and abundant mitochondria. Compared with white adipose tissue (WAT), PVAT and BAT from C57BL6/J mice fed a high-fat diet for 13 wk had markedly lower expression of immune cell-enriched mRNAs, suggesting resistance to obesity-induced inflammation. Indeed, staining of BAT and PVAT for macrophage markers (F4/80 and CD68) in obese mice showed virtually no macrophage infiltration, and FACS analysis of BAT confirmed the presence of very few CD11b(+)/CD11c(+) macrophages in BAT (1.0%) compared with WAT (31%). In summary, murine PVAT from the thoracic aorta is virtually identical to interscapular BAT, is resistant to diet-induced macrophage infiltration, and thus may play an important role in protecting the vascular bed from inflammatory stress.
C1 [Fitzgibbons, Timothy P.; Kogan, Sophia; Aouadi, Myriam; Straubhaar, Juerg; Czech, Michael P.] Univ Massachusetts, Sch Med, Program Mol Med, Worcester, MA 01605 USA.
   [Fitzgibbons, Timothy P.] Univ Massachusetts, Sch Med, Div Cardiovasc Med, Worcester, MA 01605 USA.
   [Hendricks, Greg M.] Univ Massachusetts, Sch Med, Dept Cell Biol, Worcester, MA 01605 USA.
C3 University of Massachusetts System; University of Massachusetts
   Worcester; University of Massachusetts System; University of
   Massachusetts Worcester; University of Massachusetts System; University
   of Massachusetts Worcester
RP Czech, MP (corresponding author), Univ Massachusetts, Sch Med, Program Mol Med, 373 Plantat St,Suite 100, Worcester, MA 01605 USA.
EM Michael.Czech@umassmed.edu
RI Fitzgibbons, Timothy/AAG-3700-2020; Kogan, Sophia/AAF-4315-2020
OI Fitzgibbons, Timothy/0000-0003-0229-034X
FU National Institute of Diabetes and Digestive and Kidney Diseases
   [DK-30898, DK-60837]; American Heart Association [11PRE5000000];
   American Heart Association (AHA) [11PRE5000000] Funding Source: American
   Heart Association (AHA)
FX We thank the Morphology Core Facility and the Genomics Core Facility of
   the UMASS Medical School Diabetes and Endocrinology Research Center
   (DK-32520) for assistance with histology and microarray analyses,
   respectively. These studies were supported by National Institute of
   Diabetes and Digestive and Kidney Diseases Grants DK-30898 and DK-60837
   (to M. P. Czech) and American Heart Association Predoctoral Fellowship
   Grant No. 11PRE5000000 (to T. P. Fitzgibbons).
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NR 48
TC 249
Z9 279
U1 0
U2 19
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0363-6135
J9 AM J PHYSIOL-HEART C
JI Am. J. Physiol.-Heart Circul. Physiol.
PD OCT
PY 2011
VL 301
IS 4
BP H1425
EP H1437
DI 10.1152/ajpheart.00376.2011
PG 13
WC Cardiac & Cardiovascular Systems; Physiology; Peripheral Vascular
   Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Physiology
GA 826NE
UT WOS:000295360100024
PM 21765057
OA Green Published
DA 2025-06-11
ER

PT J
AU Mahli, A
   Koch, A
   Fresse, K
   Schiergens, T
   Thasler, WE
   Schönberger, C
   Bergheim, I
   Bosserhoff, A
   Hellerbrand, C
AF Mahli, Abdo
   Koch, Andreas
   Fresse, Kim
   Schiergens, Tobias
   Thasler, Wolfgang Erwin
   Schoenberger, Christina
   Bergheim, Ina
   Bosserhoff, Anja
   Hellerbrand, Claus
TI Iso-alpha acids from hops (Humulus lupulus) inhibit hepatic
   steatosis, inflammation, and fibrosis
SO LABORATORY INVESTIGATION
LA English
DT Article
ID FATTY LIVER-DISEASE; DIET-INDUCED OBESITY; RECEPTOR-GAMMA; NONALCOHOLIC
   STEATOHEPATITIS; LIPID-ACCUMULATION; INSULIN-RESISTANCE; BITTER
   COMPONENTS; STELLATE CELLS; ISOHUMULONES; EXPRESSION
AB Non-alcoholic fatty liver disease (NAFLD) is considered to be the hepatic manifestation of the metabolic syndrome. Isoalpha acids (IAAs), hop-derived bitter compounds in beer, have been shown to beneficially affect different components of the metabolic syndrome such as insulin resistance and dyslipidemia. However, IAAs have not yet been studied in the context of chronic liver disease. Here we analyzed the effect of IAA on the pathogenesis of NAFLD. Once, we applied IAA to mice in combination with a NAFLD-inducing Western-type diet (WTD), and observed that IAA significantly inhibited WTD-induced body weight gain, glucose intolerance, and hepatic steatosis. Fitting to this, IAA dose-dependently inhibited cellular lipid accumulation in primary human hepatocytes (PHH) in vitro. Reduced expression of PPAR-gamma and key enzymes of lipid synthesis as well as increased expression of PPAR-alpha, indicative for increased lipid combustion, were identified as underlying mechanisms of reduced hepatocellular steatosis in vitro and in vivo. Analysis of hepatic HMOX1 expression indicated reduced oxidative stress in IAA-treated mice, which was paralleled by reduced activation of the JNK pathway and pro-inflammatory gene expression and immune cell infiltration. Furthermore, IAA reduced hepatic stellate cell (HSC) activation and pro-fibrogenic gene expression. Similarly, IAA also dose-dependently reduced oxidative stress and JNK activation in steatotic PHH, inhibited HSC activation, and reduced proliferation and pro-fibrogenic gene expression in already activated HSC in vitro. In conclusion, IAAs inhibit different pathophysiological steps of disease progression in NAFLD. Together with previous studies, which demonstrated the safety of even long-term application of IAA in humans, our data suggest IAA as promising therapeutic agent for the prevention and treatment of (non) alcoholic (fatty) liver disease.
C1 [Mahli, Abdo; Koch, Andreas; Fresse, Kim; Bosserhoff, Anja; Hellerbrand, Claus] Friedrich Alexander Univ Erlangen Nurnberg, Emil Fischer Zentrum, Inst Biochem, Erlangen, Germany.
   [Mahli, Abdo; Koch, Andreas; Hellerbrand, Claus] Univ Hosp Regensburg, Dept Internal Med 1, Regensburg, Germany.
   [Schiergens, Tobias; Thasler, Wolfgang Erwin] Ludwig Maximilians Univ Munchen, Dept Gen Visceral & Transplantat Surg, Biobank Ob HTCR, Munich, Germany.
   [Schoenberger, Christina] Joh Barth & Sohn GmbH & Co KG, Nurnberg, Germany.
   [Bergheim, Ina] Univ Vienna, Mol Nutr Sci, Dept Nutr Sci, Vienna, Austria.
C3 University of Erlangen Nuremberg; University of Regensburg; University
   of Munich; University of Vienna
RP Hellerbrand, C (corresponding author), Friedrich Alexander Univ Erlangen Nurnberg, Emil Fischer Zentrum, Inst Biochem, Erlangen, Germany.; Hellerbrand, C (corresponding author), Univ Hosp Regensburg, Dept Internal Med 1, Regensburg, Germany.
EM claus.hellerbrand@fau.de
RI Mahli, Abdo/AAD-4744-2019; Bosserhoff, Anja/GNH-4801-2022
OI Mahli, Abdo/0000-0002-8333-7551
FU "Wissenschaftsforderung der Deutschen Brauwirtschaft e.V." (Berlin,
   Germany) [R437]; German Research Foundation [FOR 2127, KFO262]
FX This work was supported by a grant from the "Wissenschaftsforderung der
   Deutschen Brauwirtschaft e.V." (Berlin, Germany) (Project No R437) to
   CH. CH and AB are supported by the German Research Foundation (FOR 2127
   and KFO262). We want to thank Rudolf Jung for excellent technical
   assistance. We acknowledge the Human Tissue and Cell Research (HTCR)
   Foundation for making human tissue available for research and Hepacult
   GmbH (Regensburg, Germany) for providing PHH for in vitro studies.
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NR 57
TC 21
Z9 24
U1 2
U2 19
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0023-6837
EI 1530-0307
J9 LAB INVEST
JI Lab. Invest.
PD DEC
PY 2018
VL 98
IS 12
BP 1614
EP 1626
DI 10.1038/s41374-018-0112-x
PG 13
WC Medicine, Research & Experimental; Pathology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pathology
GA HC2MC
UT WOS:000451635100009
PM 30089858
OA Bronze
DA 2025-06-11
ER

PT J
AU Levine, GN
   Lange, RA
   Bairey-Merz, CN
   Davidson, RJ
   Jamerson, K
   Mehta, PK
   Michos, ED
   Norris, K
   Ray, IB
   Saban, KL
   Shah, T
   Stein, R
   Smith, SC
AF Levine, Glenn N.
   Lange, Richard A.
   Bairey-Merz, C. Noel
   Davidson, Richard J.
   Jamerson, Kenneth
   Mehta, Puja K.
   Michos, Erin D.
   Norris, Keith
   Ray, Indranill Basu
   Saban, Karen L.
   Shah, Tina
   Stein, Richard
   Smith, Sidney C., Jr.
CA American Heart Assoc Council Clini
   Council Cardiovascular Stroke Nurs
   Council Hypertension
TI Meditation and Cardiovascular Risk Reduction A Scientific Statement From
   the American Heart Association
SO JOURNAL OF THE AMERICAN HEART ASSOCIATION
LA English
DT Article
DE AHA Scientific Statements; cardiovascular disease; cardiovascular risk;
   meditation; primary prevention; secondary prevention
ID RANDOMIZED CONTROLLED-TRIAL; INFLAMMATORY GENE-EXPRESSION; AMBULATORY
   BLOOD-PRESSURE; LIFE-STYLE CHANGES; QUALITY-OF-LIFE; STRESS REDUCTION;
   TRANSCENDENTAL-MEDITATION; MINDFULNESS MEDITATION; METABOLIC SYNDROME;
   CAROTID ATHEROSCLEROSIS
AB Despite numerous advances in the prevention and treatment of atherosclerosis, cardiovascular disease remains a leading cause of morbidity and mortality. Novel and inexpensive interventions that can contribute to the primary and secondary prevention of cardiovascular disease are of interest. Numerous studies have reported on the benefits ofmeditation. Meditation instruction and practice is widely accessible and inexpensive and may thus be a potential attractive cost-effective adjunct to more traditional medical therapies. Accordingly, this American Heart Association scientific statement systematically reviewed the data on the potential benefits of meditation on cardiovascular risk. Neurophysiological and neuroanatomical studies demonstrate that meditation can have long-standing effects on the brain, which provide some biological plausibility for beneficial consequences on the physiological basal state and on cardiovascular risk. Studies of the effects ofmeditation on cardiovascular risk have included those investigating physiological response to stress, smoking cessation, blood pressure reduction, insulin resistance and metabolic syndrome, endothelial function, inducible myocardial ischemia, and primary and secondary prevention of cardiovascular disease. Overall, studies of meditation suggest a possible benefit on cardiovascular risk, although the overall quality and, in some cases, quantity of study data are modest. Given the low costs and low risks of this intervention, meditation may be considered as an adjunct to guideline-directed cardiovascular risk reduction by those interested in this lifestyle modification, with the understanding that the benefits of such intervention remain to be better established. Further research onmeditation and cardiovascular risk iswarranted. Such studies, to the degree possible, should utilize randomized study design, be adequately powered to meet the primary study outcome, strive to achieve low drop-out rates, include long-termfollow-up, and be performed by those without inherent bias in outcome.
C1 [Levine, Glenn N.] Baylor Coll Med, Houston, TX 77030 USA.
   [Lange, Richard A.] Texas Tech Univ, Hlth Sci Ctr, Paul L Foster Sch Med, Lubbock, TX 79430 USA.
   [Bairey-Merz, C. Noel] Cedars Sinai Heart Inst, Los Angeles, CA USA.
   [Davidson, Richard J.] Univ Wisconsin, Madison, WI 53706 USA.
   [Jamerson, Kenneth] Univ Michigan Hlth Syst, Ann Arbor, MI USA.
   [Mehta, Puja K.] Emory Med Cardiol, Atlanta, GA USA.
   [Michos, Erin D.] Johns Hopkins Univ, Sch Med, Baltimore, MD USA.
   [Norris, Keith] Univ Calif Los Angeles, Los Angeles, CA 90024 USA.
   [Ray, Indranill Basu] Baylor Coll Med, Texas Heart Inst, Houston, TX 77030 USA.
   [Saban, Karen L.] Loyola Univ Chicago, Marcella Niehoff Sch Nursing, Chicago, IL USA.
   [Shah, Tina] Michael E DeBakey VA Med Ctr, Houston, TX USA.
   [Shah, Tina] Baylor Coll Med, Houston, TX 77030 USA.
   [Smith, Sidney C., Jr.] Univ N Carolina, Chapel Hill, NC 27515 USA.
   [Stein, Richard] NYU, Sch Med, New York, NY USA.
C3 Baylor College of Medicine; Texas Tech University System; Texas Tech
   University Health Sciences Center Lubbock; Cedars Sinai Medical Center;
   University of Wisconsin System; University of Wisconsin Madison;
   University of Michigan System; University of Michigan; Johns Hopkins
   University; University of California System; University of California
   Los Angeles; Texas Heart Institute; Baylor College of Medicine; Loyola
   University Chicago; Baylor College of Medicine; Baylor College Medical
   Hospital; Baylor College of Medicine; University of North Carolina;
   University of North Carolina Chapel Hill; New York University
RP Levine, GN (corresponding author), Baylor Coll Med, Houston, TX 77030 USA.
RI Ray, Indranill/D-3794-2011; Smith, Sidney/HIR-4896-2022; Lange,
   Richard/AAM-9594-2021; Saban, Karen/H-4837-2011
OI Davidson, Richard/0000-0002-8506-4964; Saban, Karen/0000-0001-5767-5453;
   Basu Ray, Indranill/0000-0003-0961-0588; Bairey Merz, C.
   Noel/0000-0002-9933-5155
FU WISE HFpEF; RWISE; Microvascular; Normal Control; FAMRI; NIDDK; Bayer;
   General Electric; Gilead Sciences; VA
FX C. Noel Bairey-Merz WISE HFpEF; RWISE; Microvascular; Normal Control;
   FAMRIKenneth Jamerson NIDDK; BayerPuja K. Mehta General Electric; Gilead
   SciencesKaren L. Saban VA (PI for VA funded grant examining Mindfulness
   in Women Veterans)
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NR 149
TC 179
Z9 192
U1 0
U2 23
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
EI 2047-9980
J9 J AM HEART ASSOC
JI J. Am. Heart Assoc.
PD OCT
PY 2017
VL 6
IS 10
AR e002218
DI 10.1161/JAHA.117.002218
PG 57
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Cardiovascular System & Cardiology
GA FR3BF
UT WOS:000418940300001
PM 28963100
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Ko, KM
   Han, K
   Chung, YJ
   Yoon, KH
   Park, YG
   Lee, SH
AF Ko, Kyung Min
   Han, Kyungdo
   Chung, Youn Jee
   Yoon, Kun-Ho
   Park, Yong Gyu
   Lee, Seung-Hwan
TI Association between Body Weight Changes and Menstrual Irregularity: The
   Korea National Health and Nutrition Examination Survey 2010 to 2012
SO ENDOCRINOLOGY AND METABOLISM
LA English
DT Article
DE Obesity; abdominal; Body weight; Menstrual irregularity; Obesity
ID INSULIN-RESISTANCE; METABOLIC SYNDROME; OBESITY; DISEASE; RISK; WOMEN;
   CYCLE; MENARCHE; STRESS; MEN
AB Background: Menstrual irregularity is an indicator of endocrine disorders and reproductive health status. It is associated with various diseases and medical conditions, including obesity and underweight. We aimed to assess the association between body weight changes and menstrual irregularity in Korean women.
   Methods: A total of 4,621 women 19 to 54 years of age who participated in the 2010 to 2012 Korea National Health and Nutrition Examination Survey were included in this study. Self-reported questionnaires were used to collect medical information assessing menstrual health status and body weight changes. Odds ratios (ORs) and 95% confidence interval (CI) were calculated to evaluate the association between body weight changes and menstrual irregularity.
   Results: Significantly higher ORs (95% CI) were observed in the association between menstrual irregularity and both weight loss (OR, 1.74; 95% CI, 1.22 to 2.48) and weight gain (OR, 1.45; 95% CI, 1.13 to 1.86) after adjusting for age, body mass index, current smoking, heavy alcohol drinking, regular exercise, calorie intake, education, income, metabolic syndrome, age of menarche, parity, and stress perception. Of note, significant associations were only observed in subjects with obesity and abdominal obesity, but not in non-obese or non-abdominally obese subjects. U-shaped patterns were demonstrated in both obese and abdominally obese subjects, indicating that greater changes in body weight are associated with higher odds of menstrual irregularity.
   Conclusion: We found a U-shaped pattern of association between body weight changes and menstrual irregularity among obese women in the general Korean population. This result indicates that not only proper weight management but also changes in body weight may influence the regulation of the menstrual cycle.
C1 [Ko, Kyung Min; Yoon, Kun-Ho; Lee, Seung-Hwan] Catholic Univ Korea, Dept Internal Med, Coll Med, Seoul, South Korea.
   [Han, Kyungdo; Park, Yong Gyu] Catholic Univ Korea, Dept Med Stat, Coll Med, 222 Banpo Daero, Seoul 06591, South Korea.
   [Chung, Youn Jee] Catholic Univ Korea, Dept Obstet & Gynecol, Coll Med, Seoul, South Korea.
   [Yoon, Kun-Ho; Lee, Seung-Hwan] Catholic Univ Korea, Coll Med, Seoul St Marys Hosp, Div Endocrinol & Metab,Dept Internal Med, 222 Banpo Daero, Seoul 06591, South Korea.
C3 Catholic University of Korea; Catholic University of Korea; Catholic
   University of Korea; Catholic University of Korea; Seoul St. Mary's
   Hospital
RP Park, YG (corresponding author), Catholic Univ Korea, Dept Med Stat, Coll Med, 222 Banpo Daero, Seoul 06591, South Korea.; Lee, SH (corresponding author), Catholic Univ Korea, Coll Med, Seoul St Marys Hosp, Div Endocrinol & Metab,Dept Internal Med, 222 Banpo Daero, Seoul 06591, South Korea.
EM ygpark@catholic.ac.kr; hwanx2@catholic.ac.kr
RI Kim, Dong Ki/J-5389-2012; Lee, Seung-Hwan/AAG-1361-2019; Han,
   Kyungdo/JKH-7628-2023; Lee, Seung-Hwan/C-7568-2018
OI Lee, Seung-Hwan/0000-0002-3964-3877
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NR 30
TC 15
Z9 16
U1 0
U2 7
PU KOREAN ENDOCRINE SOC
PI SEOUL
PA 101-2503, 109 MAPO-DAERO, MAPO-GU, SEOUL, 04146, SOUTH KOREA
SN 2093-596X
EI 2093-5978
J9 ENDOCRINOL METAB
JI Endocrinol. Metab.
PD JUN
PY 2017
VL 32
IS 2
BP 248
EP 256
DI 10.3803/EnM.2017.32.2.248
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA FD8YZ
UT WOS:000407811300013
PM 28685514
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Wadhwa, D
   Mahajan, VK
   Mehta, KS
   Chauhan, PS
   Yadav, RS
   Bhushan, S
   Sharma, V
   Sharma, A
   Sharma, A
   Chauhan, S
AF Wadhwa, Dhaarna
   Mahajan, Vikram K.
   Mehta, Karaninder S.
   Chauhan, Pushpinder S.
   Yadav, Rajinder S.
   Bhushan, Satya
   Sharma, Vikas
   Sharma, Anuj
   Sharma, Aditi
   Chauhan, Shailja
TI Malondialdehyde, lipoprotein-a, lipoprotein ratios, comprehensive lipid
   tetrad index and atherogenic index as surrogate markers for
   cardiovascular disease in patients with psoriasis: a case-control study
SO ARCHIVES OF DERMATOLOGICAL RESEARCH
LA English
DT Article
DE Cardiovascular disease risk; Dyslipidemia; Framingham risk score;
   Metabolic syndrome; Oxidative stress; Psoriasis
ID CORONARY-ARTERY-DISEASE; OXIDATIVE STRESS; PENTAD INDEX; RISK;
   PEROXIDATION; PROFILES; OXIDANT
AB Psoriasis is now recognized as an immune-mediated inflammatory dermatosis with increased risk for metabolic syndrome, its individual components, and cardiovascular disease. We quantitatively estimated malondialdehyde (MDA), lipoprotein-a (LP-a), lipoprotein ratios, comprehensive lipid tetrad index (CLTI), and atherogenic index (AI), and evaluated cardiovascular risk in 132 (M:F 94:38) patients with psoriasis aged 20-79 years with chronic plaque psoriasis and equal number of age and gender-matched controls. Lipoprotein ratios, CLTI and AI were calculated using standard formulae. Cardiovascular 10-year risk was graded by Framingham risk score (FRS) as low, intermediate and severe. Mild-to-moderate and severe psoriasis was present in 125 (94.7%), and 7 (5.3%) patients, respectively, and 19 (14.39%) patients had psoriatic arthritis. Statistically significant differences were noted for LDL, LDL/HDL, non-HDL/HDL, MDA, LP-a, AI and CLTI. There was a significantly positive correlation between PASI with LP-a (p = 0.003, r = 0.25) and AI (p = 0.012, r = 0.22). Serum levels of MDA correlated positively with LP-a (p < 0.001, r = 0.55), AI (p < 0.001, r = 0.51) and CLTI (p = 0.006, r = 0.24). FRS was low, intermediate and severe in 78%, 18.9%, and 3% patients compared to 85.6%, 13.6%, and 0.8% controls, respectively, and the difference was not statistically significant. Psoriasis appears to be an independent risk factor for elevated serum MDA, LP-a, CLTI and AI. However, whether they can be used as surrogate markers for enhanced cardiovascular risk in patients with psoriasis, remains conjectural.
C1 [Wadhwa, Dhaarna; Mahajan, Vikram K.; Mehta, Karaninder S.; Chauhan, Pushpinder S.; Sharma, Vikas; Sharma, Anuj; Sharma, Aditi; Chauhan, Shailja] Dr RP GovKangrat Med Coll, Dept Dermatol Venereol & Leprosy, Tanda 176001, Himachal Prades, India.
   [Yadav, Rajinder S.; Bhushan, Satya] Dr RP Govt Med Coll, Dept Biochem, Tanda 176001, Himachal Prades, India.
RP Mahajan, VK (corresponding author), Dr RP GovKangrat Med Coll, Dept Dermatol Venereol & Leprosy, Tanda 176001, Himachal Prades, India.
EM vkm1@rediffmail.com
RI Sharma, Vikas/JFK-9021-2023
OI Wadhwa, Dhaarna/0000-0003-1850-5392; Mahajan, Vikram/0000-0002-0537-4066
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NR 41
TC 15
Z9 15
U1 1
U2 7
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0340-3696
EI 1432-069X
J9 ARCH DERMATOL RES
JI Arch. Dermatol. Res.
PD MAY
PY 2019
VL 311
IS 4
BP 287
EP 297
DI 10.1007/s00403-019-01896-y
PG 11
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA HT9EH
UT WOS:000464868500004
PM 30830310
DA 2025-06-11
ER

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AU Jousse, C
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AF Jousse, Celine
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   Carraro, Valerie
   Tost, Jorg
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   Jockers, Ralf
   Launay, Jean-Marie
   Mallet, Jacques
   Fafournoux, Pierre
TI Perinatal undernutrition affects the methylation and expression of the
   leptin gene in adults: implication for the understanding of metabolic
   syndrome
SO FASEB JOURNAL
LA English
DT Article
DE nutritional programming; epigenetic; food intake; maternal imprinting
ID NUTRITION TRANSITION; ENERGY HOMEOSTASIS; DNA METHYLATION; OBESITY;
   LIFE; DISEASE; HYPOTHALAMUS; EPIGENETICS; EPIGENOME; PROMOTER
AB Transient environmental influences, such as perinatal nutritional stress, may induce deleterious metabolic symptoms that last for the entire life of individuals, implying that epigenetic modifications play an important role in this process. We have investigated, in mice, the consequences of maternal undernutrition during gestation and lactation on DNA methylation and expression of the leptin gene, which plays a major regulatory role in coordinating nutritional state with many aspects of mammalian biology. We show that animals born to mothers fed a low-protein-diet (F1-LPD group) have a lower body weight/adiposity and exhibit a higher food intake than animals born to mothers fed a control diet (F1-CD group). These modifications persisted throughout life and were associated with lower levels of leptin mRNA and protein in starved F1-LPD mice, emphasizing that maternal protein-undernutrition affects the balance between food intake and energy expenditure in adults. Moreover, this nutritional stress resulted in the removal of methyls at CpGs located in the promoter of leptin, causing a permanent specific modification in the dynamics of the expression of leptin, which exhibits a stronger induction in the F1-LPD than in F1-CD mice in response to a meal. This study is an example of a molecular rationale linking transient environmental influences to permanent phenotypic consequences.-Jousse, C., Parry, L., Lambert-Langlais, S., Maurin, A. C., Averous, J., Bruhat, A., Carraro, V., Tost, J., Letteron, P., Chen, P., Jockers, R., Launay, J. M., Mallet, J., Fafournoux, P. Perinatal undernutrition affects the methylation and expression of the leptin gene in adults: implication for the understanding of metabolic syndrome. FASEB J. 25, 3271-3278 (2011). www.fasebj.org
C1 [Jousse, Celine; Parry, Laurent; Lambert-Langlais, Sarah; Maurin, Anne-Catherine; Averous, Julien; Bruhat, Alain; Carraro, Valerie; Fafournoux, Pierre] INRA, UMR Unite Nutr Humaine 1019, F-63122 St Genes Champanelle, France.
   [Jousse, Celine; Fafournoux, Pierre] CNRS, Paris, France.
   [Tost, Jorg] CEA, Inst Genom, Lab Epigenet, Ctr Natl Genotypage, Evry, France.
   [Letteron, Philippe] INSERM, U773, Fac Med Xavier Bichat CRB3, Paris, France.
   [Chen, Patty; Jockers, Ralf] CNRS, INSERM, U1016, UMR 8104,Inst Cochin, Paris, France.
   [Launay, Jean-Marie] Univ Paris 05, Hop Lariboisiere, AP HP, Serv Biochim & Biol Mol,EA 3621,Fac Pharm, Paris, France.
   [Mallet, Jacques] Univ Paris 06, Hop La Pitie Salpetriere, CNRS,UMR 7091, Lab Genet Mol Neurotransmiss & Proc Neurodegenera, Paris, France.
C3 INRAE; Centre National de la Recherche Scientifique (CNRS); Universite
   Paris Saclay; CEA; Institut National de la Sante et de la Recherche
   Medicale (Inserm); Universite Paris Cite; Institut National de la Sante
   et de la Recherche Medicale (Inserm); Universite Paris Cite; Centre
   National de la Recherche Scientifique (CNRS); CNRS - National Institute
   for Biology (INSB); Universite Paris Cite; Assistance Publique Hopitaux
   Paris (APHP); Hopital Universitaire Lariboisiere-Fernand-Widal - APHP;
   Centre National de la Recherche Scientifique (CNRS); Assistance Publique
   Hopitaux Paris (APHP); Hopital Universitaire Pitie-Salpetriere - APHP;
   Sorbonne Universite
RP Fafournoux, P (corresponding author), INRA, UMR Nutr Humaine 1019, F-63122 St Genes Champanelle, France.
EM pierre.fafournoux@clermont.inra.fr
RI Jockers, Ralf/Q-2100-2019; jousse, celine/NDS-0480-2025; Tost,
   Jorg/H-7129-2019; Jockers, Ralf/P-2272-2017
OI Tost, Jorg/0000-0002-2683-0817; Jockers, Ralf/0000-0002-4354-1750
FU Agence Nationale de la Recherche Epidiabesity
FX The authors thank Anne Terrisse for animal care and Rolando Meloni and
   Nicole Faucon for critical reading of the manuscript. Funding for this
   project has been supplied by Agence Nationale de la Recherche
   Epidiabesity.
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NR 36
TC 119
Z9 131
U1 0
U2 33
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
EI 1530-6860
J9 FASEB J
JI Faseb J.
PD SEP
PY 2011
VL 25
IS 9
BP 3271
EP 3278
DI 10.1096/fj.11-181792
PG 8
WC Biochemistry & Molecular Biology; Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 814GD
UT WOS:000294435200039
PM 21670064
OA Bronze
DA 2025-06-11
ER

PT J
AU Haddad, C
   Sacre, H
   Hallit, S
   Obeid, S
   Al-Zein, D
   Nabout, R
   Zoghbi, M
   Haddad, G
AF Haddad, Chadia
   Sacre, Hala
   Hallit, Souheil
   Obeid, Sahar
   Al-Zein, Darine
   Nabout, Rita
   Zoghbi, Marouan
   Haddad, Georges
TI Prevalence of comorbidities and correlates of hospital readmission rate
   in patients with acute mania: A one-year retrospective data from a
   tertiary care
SO PERSPECTIVES IN PSYCHIATRIC CARE
LA English
DT Article
DE acute mania; comorbidity; hospital readmission rates; management;
   psychosis
ID BIPOLAR DISORDER; METABOLIC SYNDROME; MOOD EPISODES; RISK-FACTORS;
   GENDER; SCHIZOPHRENIA; INDIVIDUALS; DEPRESSION; GUIDELINES; ADHERENCE
AB Objective To assess the prevalence of medical comorbidities in acute manic patients over a period of 1 year, and to evaluate correlates of the readmission rate. Design/Methods A retrospective observational study was conducted on 158 acute manic patients from 2016 to 2017. Results The most common physical comorbidity was obesity (36.1%) followed by cardiovascular disorders (15.2%) and liver dysfunctions (9.3%). Male gender was associated with higher readmission rate (Beta = -0.260), while taking anticholinergic drugs (Beta = -0.338) and having a family history of psychiatric disorders (Beta = -0.222) were associated with lower readmission rate. Practical implications The study results may help physicians and other clinicians understand the burden of illness recurrence in bipolar disorder type I patients and adopt effective strategies to prevent relapse, taking into account all comorbidities.
C1 [Haddad, Chadia; Obeid, Sahar; Zoghbi, Marouan; Haddad, Georges] Psychiat Hosp Cross, Dept Res, Jal Eddib, Lebanon.
   [Haddad, Chadia; Obeid, Sahar; Zoghbi, Marouan; Haddad, Georges] Psychiat Hosp Cross, Dept Psychol, Jal Eddib, Lebanon.
   [Haddad, Chadia; Obeid, Sahar; Zoghbi, Marouan; Haddad, Georges] Psychiat Hosp Cross, Dept Psychiat, Jal Eddib, Lebanon.
   [Sacre, Hala] Order Pharmacists Lebanon, Drug Informat Ctr, Beirut, Lebanon.
   [Sacre, Hala; Hallit, Souheil; Obeid, Sahar] INSPECT LB Inst Natl Sante Publ Epidemiol Clin &, Beirut, Lebanon.
   [Hallit, Souheil; Haddad, Georges] Holy Spirit Univ Kaslik USEK, Fac Med & Med Sci, Jounieh, Lebanon.
   [Obeid, Sahar] Holy Spirit Univ Kaslik USEK, Fac Arts & Sci, Dept Psychol, Jounieh, Lebanon.
   [Al-Zein, Darine; Nabout, Rita; Haddad, Georges] Lebanese Univ, Fac Sci 2, Dept Life & Earth Sci, Beirut, Lebanon.
   [Zoghbi, Marouan] St Joseph Univ, Dept Family Med, Beirut, Lebanon.
C3 Lebanese University
RP Hallit, S (corresponding author), Bldg 560,St 8,1st Floor, Biakout, Lebanon.; Haddad, G (corresponding author), Psychiat Hosp Cross, POB 60096, Jall Eddib, Lebanon.
EM souheilhallit@hotmail.com; georgeshaddad.hpc@gmail.com
RI ZOGHBI, MAROUAN/AFQ-3579-2022; Hallit, Souheil/R-6727-2018; Sacre,
   Hala/O-7644-2019
OI Hallit, Souheil/0000-0001-6918-5689; Haddad, Chadia/0000-0003-2413-2684;
   Sacre, Hala/0000-0001-6547-6251
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NR 62
TC 1
Z9 1
U1 1
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0031-5990
EI 1744-6163
J9 PERSPECT PSYCHIATR C
JI Perspect. Psychiatr. Care
PD OCT
PY 2020
VL 56
IS 4
BP 753
EP 759
DI 10.1111/ppc.12464
EA DEC 2019
PG 7
WC Nursing; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Psychiatry
GA OC4DG
UT WOS:000502082700001
PM 31828814
OA gold
DA 2025-06-11
ER

PT J
AU Ipsen, DH
   Tveden-Nyborg, P
   Lykkesfeldt, J
AF Ipsen, David Hojland
   Tveden-Nyborg, Pernille
   Lykkesfeldt, Jens
TI Does Vitamin C Deficiency Promote Fatty Liver Disease Development?
SO NUTRIENTS
LA English
DT Review
DE antioxidants; obesity; oxidative stress; non-alcoholic fatty liver
   disease; non-alcoholic steatohepatitis; reactive oxygen species; vitamin
   C; vitamin C deficiency
ID ASCORBIC-ACID DEFICIENCY; NUTRITION EXAMINATION SURVEY; INCREASED
   OXIDATIVE STRESS; MORBIDLY OBESE-PATIENTS; 3RD NATIONAL-HEALTH;
   INSULIN-RESISTANCE; GUINEA-PIGS; NONALCOHOLIC STEATOHEPATITIS; METABOLIC
   SYNDROME; ADIPOSE-TISSUE
AB Obesity and the subsequent reprogramming of the white adipose tissue are linked to human disease-complexes including metabolic syndrome and concurrent non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH). The dietary imposed dyslipidemia promotes redox imbalance by the generation of excess levels of reactive oxygen species and induces adipocyte dysfunction and reprogramming, leading to a low grade systemic inflammation and ectopic lipid deposition, e.g., in the liver, hereby promoting a vicious circle in which dietary factors initiate a metabolic change that further exacerbates the negative consequences of an adverse life-style. Large epidemiological studies and findings from controlled in vivo animal studies have provided evidence supporting an association between poor vitamin C (VitC) status and propagation of life-style associated diseases. In addition, overweight per se has been shown to result in reduced plasma VitC, and the distribution of body fat in obesity has been shown to have an inverse relationship with VitC plasma levels. Recently, a number of epidemiological studies have indicated a VitC intake below the recommended daily allowance (RDA) in NAFLD-patients, suggesting an association between dietary habits, disease and VitC deficiency. In the general population, VitC deficiency (defined as a plasma concentration below 23 mu M) affects around 10% of adults, however, this prevalence is increased by an adverse life-style, deficiency potentially playing a broader role in disease progression in specific subgroups. This review discusses the currently available data from human surveys and experimental models in search of a putative role of VitC deficiency in the development of NAFLD and NASH.
C1 [Ipsen, David Hojland; Tveden-Nyborg, Pernille; Lykkesfeldt, Jens] Univ Copenhagen, Dept Vet Dis Biol, Fac Hlth & Med Sci, DK-1870 Frederiksberg C, Denmark.
C3 University of Copenhagen
RP Lykkesfeldt, J (corresponding author), Univ Copenhagen, Dept Vet Dis Biol, Fac Hlth & Med Sci, Ridebanevej 9, DK-1870 Frederiksberg C, Denmark.
EM dhi@sund.ku.dk; ptn@sund.ku.dk; jopl@sund.ku.dk
RI Lykkesfeldt, Jens/A-1072-2011
OI Lykkesfeldt, Jens/0000-0002-6514-8407; Tveden-Nyborg,
   Pernille/0000-0002-5574-5742; Ipsen, David/0000-0002-2065-8497
FU LifePharm Centre for in Vivo Pharmacology
FX D.H.I. and J.L. are supported by the LifePharm Centre for in Vivo
   Pharmacology.
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NR 129
TC 51
Z9 54
U1 1
U2 29
PU MDPI AG
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 2072-6643
J9 NUTRIENTS
JI Nutrients
PD DEC
PY 2014
VL 6
IS 12
BP 5473
EP 5499
DI 10.3390/nu6125473
PG 27
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA AX2TA
UT WOS:000346796100006
PM 25533004
OA Green Submitted, gold, Green Published
DA 2025-06-11
ER

PT J
AU Pepping, JK
   Freeman, LR
   Gupta, S
   Keller, JN
   Bruce-Keller, AJ
AF Pepping, Jennifer K.
   Freeman, Linnea R.
   Gupta, Sunita
   Keller, Jeffrey N.
   Bruce-Keller, Annadora J.
TI NOX2 deficiency attenuates markers of adiposopathy and brain injury
   induced by high-fat diet
SO AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
LA English
DT Article
DE brain injury; metabolic syndrome; NADPH oxidase; obesity
ID CHRONIC GRANULOMATOUS-DISEASE; INCREASED OXIDATIVE STRESS; KAPPA-B
   ACTIVATION; NADPH OXIDASE; COGNITIVE IMPAIRMENT; ADIPOSE-TISSUE;
   CEREBRAL HYPOPERFUSION; RESPIRATORY BURST; SYNAPTIC PLASTICITY;
   INSULIN-RESISTANCE
AB Pepping JK, Freeman LR, Gupta S, Keller JN, Bruce-Keller AJ. NOX2 deficiency attenuates markers of adiposopathy and brain injury induced by high-fat diet. Am J Physiol Endocrinol Metab 304: E392-E404, 2013. First published December 11, 2012; doi:10.1152/ajpendo.00398.2012.-The consumption of high-fat/calorie diets in modern societies is likely a major contributor to the obesity epidemic, which can increase the prevalence of cancer, cardiovascular disease, and neurological impairment. Obesity may precipitate decline via inflammatory and oxidative signaling, and one factor linking inflammation to oxidative stress is the proinflammatory, pro-oxidant enzyme NADPH oxidase. To reveal the role of NADPH oxidase in the metabolic and neurological consequences of obesity, the effects of high-fat diet were compared in wild-type C57B1/6 (WT) mice and in mice deficient in the NAPDH oxidase subunit NOX2 (NOX2KO). While diet-induced weight gains in WT and NOX2KO mice were similar, NOX2KO mice had smaller visceral adipose deposits, attenuated visceral adipocyte hypertrophy, and diminished visceral adipose macrophage infiltration. Moreover, the detrimental effects of HFD on markers of adipocyte function and injury were attenuated in NOX2KO mice; NOX2KO mice had improved glucose regulation, and evaluation of NOX2 expression identified macrophages as the primary population of NOX2-positive cells in visceral adipose. Finally, brain injury was assessed using markers of cerebrovascular integrity, synaptic density, and reactive gliosis, and data show that high-fat diet disrupted marker expression in WT but not NOX2KO mice. Collectively, these data indicate that NOX2 is a significant contributor to the pathogenic effects of high-fat diet and reinforce a key role for visceral adipose inflammation in metabolic and neurological decline. Development of NOX-based therapies could accordingly preserve metabolic and neurological function in the context of metabolic syndrome.
C1 [Pepping, Jennifer K.; Freeman, Linnea R.; Gupta, Sunita; Keller, Jeffrey N.; Bruce-Keller, Annadora J.] Louisiana State Univ Syst, Pennington Biomed Res Ctr, Baton Rouge, LA USA.
C3 Louisiana State University System; Louisiana State University;
   Pennington Biomedical Research Center
RP Bruce-Keller, AJ (corresponding author), Louisiana State Univ, Pennington Biomed Res Ctr, Inflammat & Neurodegenerat Lab, 6400 Perkins Rd, Baton Rouge, LA 70808 USA.
EM annadora.bruce-keller@pbrc.edu
RI Bruce-Keller, Annadora/N-1954-2017; Keller, Jeffrey/N-1975-2017
OI keller, jeffrey/0000-0002-9892-7423
FU National Institutes of Health [AG-05119]; NIH [P20 RR-021945, P30
   DK-072476]
FX This work was supported by the National Institutes of Health (AG-05119)
   and used PBRC Core facilities (Animal Phenotyping and Imaging) funded by
   the NIH (P20 RR-021945 and P30 DK-072476).
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NR 97
TC 76
Z9 85
U1 0
U2 12
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0193-1849
EI 1522-1555
J9 AM J PHYSIOL-ENDOC M
JI Am. J. Physiol.-Endocrinol. Metab.
PD FEB
PY 2013
VL 304
IS 4
BP E392
EP E404
DI 10.1152/ajpendo.00398.2012
PG 13
WC Endocrinology & Metabolism; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Physiology
GA 092SI
UT WOS:000315141900007
PM 23233541
OA Green Published
DA 2025-06-11
ER

PT J
AU Adachi, H
   Kondo, T
   Ogawa, R
   Sasaki, K
   Morino-Koga, S
   Sakakida, M
   Kawashima, J
   Motoshima, H
   Furukawa, N
   Tsuruzoe, K
   Miyamura, N
   Kai, H
   Araki, E
AF Adachi, Hironori
   Kondo, Tatsuya
   Ogawa, Rei
   Sasaki, Kazunari
   Morino-Koga, Saori
   Sakakida, Michiharu
   Kawashima, Junji
   Motoshima, Hiroyuki
   Furukawa, Noboru
   Tsuruzoe, Kaku
   Miyamura, Nobuhiro
   Kai, Hirofumi
   Araki, Eiichi
TI An acylic polyisoprenoid derivative, geranylgeranylacetone protects
   against visceral adiposity and insulin resistance in high-fat-fed mice
SO AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
LA English
DT Article
DE heat shock protein 72; diabetes; obesity
ID HEAT-SHOCK PROTEINS; ENDOPLASMIC-RETICULUM STRESS; NONTOXIC
   HEAT-SHOCK-PROTEIN-70 INDUCER; GERANYL-GERANYL-ACETONE; N-TERMINAL
   KINASE; ISCHEMIA-REPERFUSION; METABOLIC SYNDROME; OXIDATIVE STRESS;
   GASTRIC-MUCOSA; RAT-HEART
AB Adachi H, Kondo T, Ogawa R, Sasaki K, Morino-Koga S, Sakakida M, Kawashima J, Motoshima H, Furukawa N, Tsuruzoe K, Miyamura N, Kai H, Araki E. An acylic polyisoprenoid derivative, geranylgeranylacetone protects against visceral adiposity and insulin resistance in high-fat-fed mice. Am J Physiol Endocrinol Metab 299: E764-E771, 2010. First published August 17, 2010; doi: 10.1152/ajpendo.00075.2010.-Induction of heat shock protein (HSP) 72 improves insulin resistance and obesity in diabetic animal models. Geranylgeranylacetone (GGA), known as an antiulcer drug, induces HSP72 and protects organs against several cellular stresses. This study investigated whether GGA administration would induce HSP72 in liver and render physiological protection against high-fat feeding in mice. A single and 4-wk oral administration of 200 mg/kg GGA was performed in high-fat diet (HFD)-fed mice. Metabolic parameters, cytokines, and gene expressions related to insulin signaling were evaluated. A single administration of GGA induced HSP72 in liver of normal chow-fed and HFD-fed mice. Insulin resistance after HFD was slightly ameliorated. Four weeks of GGA administration also increased HSP72 in liver and significantly improved insulin resistance and glucose homeostasis upon glucose challenge. Activation of c-jun NH2-terminal kinase (JNK) was attenuated, and insulin signaling was improved in the liver of HFD mice. Visceral adiposity was decreased in GGA-treated mice, accompanied by reduced leptin and increased adiponectin levels. GGA can be a novel therapeutic approach to treat metabolic syndrome as well as type 2 diabetes by improving insulin signaling and reducing adiposity. These beneficial effects of GGA could be mediated through HSP72 induction and JNK inactivation in the liver.
C1 [Adachi, Hironori; Kondo, Tatsuya; Sasaki, Kazunari; Kawashima, Junji; Motoshima, Hiroyuki; Furukawa, Noboru; Tsuruzoe, Kaku; Miyamura, Nobuhiro; Araki, Eiichi] Kumamoto Univ, Fac Life Sci, Dept Metab Med, Honjo, Japan.
   [Ogawa, Rei; Sakakida, Michiharu] Prefectural Univ Kumamoto, Dept Environm & Symbiot Sci, Tsukide, Japan.
   [Morino-Koga, Saori; Kai, Hirofumi] Kumamoto Univ, Dept Mol Med, Grad Sch Pharmaceut Sci, Global Ctr Excellence Cell Fate Regulat Res & Edu, Kumamoto 8608556, Japan.
C3 Kumamoto University; Kumamoto University
RP Araki, E (corresponding author), Kumamoto Univ, Fac Life Sci, Dept Metab Med, 1-1-1 Honjo, Kumamoto 8608556, Japan.
EM earaki@gpo.kumamoto-u.ac.jp; earaki@gpo.kumamoto-u.ac.jp
OI Kondo, Tatsuya/0000-0003-4830-8955
FU Ministry of Education, Science, Sports, and Culture of Japan [19591058];
   Suzuken Memorial Foundation; Japan Society for the Promotion of Science,
   Japan [16046219, 20390259]; Metabolic Syndrome Research Funding of
   Kissei Pharmaceutical; Kumamoto University; World Intellectual Property
   Organization [WO 2008/038912 A1]; Grants-in-Aid for Scientific Research
   [16046219, 19591058] Funding Source: KAKEN
FX This work was supported by a grant from the Ministry of Education,
   Science, Sports, and Culture of Japan (no. 19591058 to T. Kondo), a
   grant from the Suzuken Memorial Foundation (To T. Kondo), a Grant-in-Aid
   for Scientific Research from the Japan Society for the Promotion of
   Science, Japan (nos. 16046219 and 20390259 to E. Araki), and a grant
   from Metabolic Syndrome Research Funding of Kissei Pharmaceutical (to E.
   Araki). This work was supported in part by the Advanced Education
   Program for Integrated Clinical, Basic, and Social Medicine, Graduate
   School of Medical Sciences, Kumamoto University (Program for Enhancing
   Systematic Education in Graduate Schools, Ministry of Education,
   Culture, Sports, Science, and Technology, Japan; to H. Adachi). This
   work was patented by the World Intellectual Property Organization (WO
   2008/038912 A1).
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NR 56
TC 24
Z9 27
U1 0
U2 4
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0193-1849
J9 AM J PHYSIOL-ENDOC M
JI Am. J. Physiol.-Endocrinol. Metab.
PD NOV
PY 2010
VL 299
IS 5
BP E764
EP E771
DI 10.1152/ajpendo.00075.2010
PG 8
WC Endocrinology & Metabolism; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Physiology
GA 673LX
UT WOS:000283665600009
PM 20716696
DA 2025-06-11
ER

PT J
AU Serrano-Gonzalez, M
   McConnel, C
   Bokhary, M
   Oden, J
   Lopez, X
AF Serrano-Gonzalez, Monica
   McConnel, Charles
   Bokhary, Mahmoud
   Oden, Jon
   Lopez, Ximena
TI Association of Non-High-Density Lipoprotein Cholesterol with
   Psychosocial Dysfunction in Children and Adolescents with Obesity
SO CHILDHOOD OBESITY
LA English
DT Article
ID MAJOR DEPRESSIVE DISORDER; METABOLIC SYNDROME; SERUM-CHOLESTEROL;
   FLUOXETINE; SEROTONIN; RISK; GENE
AB Background: Children with obesity have worse psychosocial functioning compared to their nonoverweight peers. Adult studies suggest that several metabolic factors may participate in the etiology of depression in obesity. Methods: We evaluated the association of several metabolic parameters with psychosocial dysfunction in children with obesity, through a retrospective review of electronic medical records in patients ages 6-17. All parents were asked to complete the Pediatric Symptom Checklist (PSC) questionnaire, a validated measurement of psychosocial dysfunction in children. Results: PSC scores were available in 618 patients. Overall, 11.2% of patients had a PSC score 28, suggestive of psychosocial dysfunction. Non-high-density lipoprotein (HDL) cholesterol was associated with a higher PSC score (p=0.02), after adjusting for age, sex, race, socioeconomic status, and BMI z-score. Conclusions: Consistent with adult studies, in children and adolescents with obesity, non-HDL cholesterol may play a role in the etiology of psychosocial dysfunction. Further studies are warranted.
C1 [Serrano-Gonzalez, Monica] Childrens Hosp Los Angeles, Los Angeles, CA 90027 USA.
   [McConnel, Charles] Univ Texas SW Med Ctr Dallas, Health Care Sci & Family & Community Med, Dallas, TX 75390 USA.
   [Bokhary, Mahmoud] Cairo Univ, Sch Med, Cairo, Egypt.
   [Oden, Jon; Lopez, Ximena] Univ Texas SW Med Ctr Dallas, Dept Pediat, Dallas, TX 75390 USA.
   [Oden, Jon; Lopez, Ximena] Childrens Med Ctr, Dallas, TX 75390 USA.
C3 Children's Hospital Los Angeles; University of Texas System; University
   of Texas Southwestern Medical Center Dallas; Egyptian Knowledge Bank
   (EKB); Cairo University; University of Texas System; University of Texas
   Southwestern Medical Center Dallas
RP Lopez, X (corresponding author), Univ Texas SW Med Ctr Dallas, Div Pediat Endocrinol, Dept Pediat, 5323 Harry Hines Blvd, Dallas, TX 75390 USA.
EM Ximena.Lopez@utsouthwestern.edu
OI Bokhary, Mahmoud/0000-0001-8862-2821
CR [Anonymous], 2000, ADV DATA, V314, P1
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NR 20
TC 3
Z9 3
U1 0
U2 5
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 2153-2168
EI 2153-2176
J9 CHILD OBES
JI Child Obes.
PD OCT 1
PY 2015
VL 11
IS 5
BP 647
EP 649
DI 10.1089/chi.2015.0043
PG 3
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Pediatrics
GA CS7NE
UT WOS:000362269500021
PM 26382177
DA 2025-06-11
ER

PT J
AU Ballard, KD
   Mah, E
   Guo, Y
   Pei, RS
   Volek, JS
   Bruno, RS
AF Ballard, Kevin D.
   Mah, Eunice
   Guo, Yi
   Pei, Ruisong
   Volek, Jeff S.
   Bruno, Richard S.
TI Low-Fat Milk Ingestion Prevents Postprandial Hyperglycemia-Mediated
   Impairments in Vascular Endothelial Function in Obese Individuals with
   Metabolic Syndrome
SO JOURNAL OF NUTRITION
LA English
DT Article
ID LOW-DENSITY-LIPOPROTEIN; BLOOD-PRESSURE; WHEY PROTEINS;
   CARDIOVASCULAR-DISEASE; INSULIN-RESISTANCE; OXIDATIVE STRESS;
   RISK-FACTORS; AGED MEN; IN-VIVO; HEALTHY
AB Greater intakes of low-fat dairy foods are associated with a lower risk of cardiovascular disease. The objective of this study was to examine whether acute low-fat milk ingestion would limit postprandial impairments in vascular endothelial function by limiting oxidative stress responses that decrease. nitric oxide (NO) bioavailability. A randomized, double-blind, crossover study was conducted in adults with metabolic syndrome (MetS) who ingested low-fat milk (475 mL) or an isocaloric volume of rice milk after an overnight fast. Brachial artery flow-mediated dilation (FMD), plasma glucose, malondialdehyde (MDA), arginine (ARG), and asymmetric dimethylarginine (ADMA) were assessed at 30-min intervals during the 3-h postprandial period. Participants' (n = 19) postprandial FMD responses were unaffected by low-fat milk but transiently decreased (P < 0.01) from 6.2 +/- 0.8% (mean +/- SEM) at baseline to 3.3 +/- 0.7% at 30 min and 3.9 +/- 0.6% at 60 min following rice milk consumption. Glucose and MDA increased to a greater extent in the rice milk trial (P<0.001). The MDA area under the 3 h postprandial curve (AUC(0-3) (h)) was correlated with glucose AUC(0-3) (h) (r = 0.75; P < 0.01) and inversely related to FM D AUC(0-3) (h) (r=-0.59; P<0.01). ARG decreased following rice milk and increased with low-fat milk, whereas only rice milk increased ADMA:ARG. The ADMA:ARG AUC(0-3) (h) was correlated with MDA AUC(0-3) (h) (r = 0.55) and was inversely related to FMD AUC(0-3) (h) (r = -0.52) (P < 0.05). These findings suggest that low-fat milk maintains vascular endothelial function in individuals with MetS by limiting postprandial hyperglycemia that otherwise increases lipid peroxidation and reduces NO bioavailability. This trial was registered at clinicaltrials.gov as NCT01411293.
C1 [Ballard, Kevin D.] Univ Connecticut, Dept Nutr Sci, Storrs, CT USA.
   [Volek, Jeff S.] Univ Connecticut, Dept Kinesiol, Storrs, CT USA.
   [Mah, Eunice; Guo, Yi; Pei, Ruisong; Bruno, Richard S.] Ohio State Univ, Dept Human Sci, Columbus, OH 43210 USA.
C3 University of Connecticut; University of Connecticut; University System
   of Ohio; Ohio State University
RP Bruno, RS (corresponding author), Ohio State Univ, Dept Human Sci, Columbus, OH 43210 USA.
EM bruno.27@osu.edu
RI Bruno, Richard/K-1930-2012
OI Bruno, Richard/0000-0002-6772-2038; Ballard, Kevin/0000-0001-7587-1220
FU Dairy Research Institute
FX Supported by a grant to R.S.B. from the Dairy Research Institute.
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NR 55
TC 35
Z9 40
U1 0
U2 12
PU AMER SOC NUTRITION-ASN
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-3166
EI 1541-6100
J9 J NUTR
JI J. Nutr.
PD OCT
PY 2013
VL 143
IS 10
BP 1602
EP 1610
DI 10.3945/jn.113.179465
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 298NW
UT WOS:000330331700010
PM 23966328
OA Bronze
DA 2025-06-11
ER

PT J
AU Bhandiwad, AR
   Valenta, I
   Jain, S
   Schindler, TH
AF Bhandiwad, Anita R.
   Valenta, Ines
   Jain, Sudhir
   Schindler, Thomas H.
TI PET-determined prevalence of coronary microvascular dysfunction and
   different types in a cardio-metabolic risk population
SO IJC HEART & VASCULATURE
LA English
DT Article
DE Cardiovascular Risk factors; Coronary Artery disease; Coronary
   Microvascular Dysfunction; Metabolic Syndrome; Myocardial Blood flow;
   Myocardial Flow reserve; Obesity; Positron Emission Tomography
ID CIRCULATORY DYSFUNCTION; FLOW RESERVE; BLOOD-FLOW; CRITERIA
AB Background: The aim was to investigate the prevalence of "classical" (predominantly related to alterations in hyperemic MBFs) and "endogen" (predominantly related to alterations in resting MBF) normal coronary microvascular function (nCMF) or coronary microvascular dysfunction (CMD) in a clinical population without flow-limiting obstructive CAD.Methods: We prospectively enrolled 239 symptomatic patients with normal pharmacologically-stress and rest myocardial perfusion on 13N-ammonia PET/CT. 13N-ammonia PET/CT concurrently assessed myocardial flow reserve (MFR = MBF stress/MBF rest). Normal nCMF was defined by a MFR of & GE; 2.0, while an abnormal MFR of < 2.0 signified CMD. In addition, patients were subgrouped into classical and endogen type of nCMF and CMD, respectively.Results: In the whole study population, CMD was present in 54% (130/239). The classical type was more prevalent than the endogen type of CMD (65% vs 35%, p < 0.008). The classical type of CMD was paralleled by a high prevalence of diabetes mellitus, metabolic syndrome, and obesity, while the endogen type of CMD was accompanied by a higher prevalence of arterial hypertension, obesity, and/or morbid obesity. Further, the classical type of nCMF was more frequently observed that the endogen type (74% vs. 26%, p < 0.007). The endogen type of nCMF was related to lower heart rate and/or arterial blood pressures.Conclusions: In this contemporary clinical study population, slightly more than half of symptomatic patients had CMD with predominance of the classical type. These observations emphasize the need for standardized reporting of CMD to gear individualized and/or intensified medical treatment to improve symptoms and/or clinical outcome in these patients.
C1 [Bhandiwad, Anita R.; Jain, Sudhir; Schindler, Thomas H.] Washington Univ, Mallinckrodt Inst Radiol, Div Nucl Med, Cardiovasc Med,Sch Med, St Louis, MO USA.
   [Bhandiwad, Anita R.; Valenta, Ines; Jain, Sudhir; Schindler, Thomas H.] Washington Univ, Sch Med, John T Milliken Dept Internal Med, Cardiovasc Div, St Louis, MO USA.
   [Schindler, Thomas H.] Washington Univ, Mallinckrodt Inst Radiol, Div Nucl Med, 510 S Kingshighway, Campus POB 8223, St Louis, MO 63110 USA.
C3 Washington University (WUSTL); Washington University (WUSTL); Washington
   University (WUSTL)
RP Schindler, TH (corresponding author), Washington Univ, Mallinckrodt Inst Radiol, Div Nucl Med, 510 S Kingshighway, Campus POB 8223, St Louis, MO 63110 USA.
EM thschindler@wustl.edu
OI Schindler, Thomas Hellmut/0000-0002-2141-7716
FU Departmental fund from Washington University [12-3271-93128]
FX Departmental fund from Washington University (Dr. Schindler, No
   12-3271-93128) in St. Louis, Missouri, USA.
CR CZERNIN J, 1993, CIRCULATION, V88, P62, DOI 10.1161/01.CIR.88.1.62
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   Verma A, 2022, EUR J CLIN INVEST, V52, DOI 10.1111/eci.13871
NR 24
TC 11
Z9 11
U1 0
U2 1
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
EI 2352-9067
J9 IJC HEART VASC
JI IJC Heart Vasc.
PD JUN
PY 2023
VL 46
AR 101206
DI 10.1016/j.ijcha.2023.101206
EA APR 2023
PG 7
WC Cardiac & Cardiovascular Systems
WE Emerging Sources Citation Index (ESCI)
SC Cardiovascular System & Cardiology
GA O5BB4
UT WOS:001043952200001
PM 37113650
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Contreras-Shannon, V
   Heart, DL
   Paredes, RM
   Navaira, E
   Catano, G
   Maffi, SK
   Walss-Bass, C
AF Contreras-Shannon, Veronica
   Heart, Dylan L.
   Paredes, R. Madelaine
   Navaira, Erica
   Catano, Gabriel
   Maffi, Shivani Kaushal
   Walss-Bass, Consuelo
TI Clozapine-Induced Mitochondria Alterations and Inflammation in Brain and
   Insulin-Responsive Cells
SO PLOS ONE
LA English
DT Article
ID INDUCED METABOLIC ALTERATIONS; OXIDATIVE STRESS; RAT-BRAIN;
   ANTIPSYCHOTIC MEDICATIONS; POSSIBLE MECHANISM; ENERGY-METABOLISM;
   OBESITY; DYSFUNCTION; RESISTANCE; SCHIZOPHRENIA
AB Background: Metabolic syndrome (MetS) is a constellation of factors including abdominal obesity, hyperglycemia, dyslipidemias, and hypertension that increase morbidity and mortality from diabetes and cardiovascular diseases and affects more than a third of the population in the US. Clozapine, an atypical antipsychotic used for the treatment of schizophrenia, has been found to cause drug-induced metabolic syndrome (DIMS) and may be a useful tool for studying cellular and molecular changes associated with MetS and DIMS. Mitochondria dysfunction, oxidative stress and inflammation are mechanisms proposed for the development of clozapine-related DIMS. In this study, the effects of clozapine on mitochondrial function and inflammation in insulin responsive and obesity-associated cultured cell lines were examined.
   Methodology/Principal Findings: Cultured mouse myoblasts (C2C12), adipocytes (3T3-L1), hepatocytes (FL-83B), and monocytes (RAW 264.7) were treated with 0, 25, 50 and 75 mu M clozapine for 24 hours. The mitochondrial selective probe TMRM was used to assess membrane potential and morphology. ATP levels from cell lysates were determined by bioluminescence assay. Cytokine levels in cell supernatants were assessed using a multiplex array. Clozapine was found to alter mitochondria morphology, membrane potential, and volume, and reduce ATP levels in all cell lines. Clozapine also significantly induced the production of proinflammatory cytokines IL-6, GM-CSF and IL12-p70, and this response was particularly robust in the monocyte cell line.
   Conclusions/ Significance: Clozapine damages mitochondria and promotes inflammation in insulin responsive cells and obesity-associated cell types. These phenomena are closely associated with changes observed in human and animal studies of MetS, obesity, insulin resistance, and diabetes. Therefore, the use of clozapine in DIMS may be an important and relevant tool for investigating cellular and molecular changes associated with the development of these diseases in the general population.
C1 [Contreras-Shannon, Veronica; Heart, Dylan L.] St Marys Univ, Dept Biol Sci, San Antonio, TX USA.
   [Paredes, R. Madelaine; Navaira, Erica; Walss-Bass, Consuelo] Univ Texas Hlth Sci Ctr San Antonio, Dept Psychiat, San Antonio, TX 78229 USA.
   [Catano, Gabriel] Univ Texas Hlth Sci Ctr San Antonio, Dept Med, San Antonio, TX 78229 USA.
   [Catano, Gabriel] Univ Texas Hlth Sci Ctr San Antonio, Vet Adm Ctr Personalized Med, South Texas Vet Hlth Care Syst, San Antonio, TX 78229 USA.
   [Maffi, Shivani Kaushal] Univ Texas Hlth Sci Ctr San Antonio, Dept Mol Med, San Antonio, TX 78229 USA.
   [Maffi, Shivani Kaushal] Reg Acad Hlth Ctr Edinburg, Div Med Res, Edinburg, TX USA.
C3 University of Texas System; University of Texas Health Science Center at
   San Antonio; University of Texas System; University of Texas Health
   Science Center at San Antonio; University of Texas System; University of
   Texas Health Science Center at San Antonio; US Department of Veterans
   Affairs; Veterans Health Administration (VHA); Audie L. Murphy Memorial
   Veterans Hospital; University of Texas System; University of Texas
   Health Science Center at San Antonio
RP Walss-Bass, C (corresponding author), Univ Texas Hlth Sci Ctr San Antonio, Dept Psychiat, San Antonio, TX 78229 USA.
EM walss@uthscsa.edu
RI Catano, Gabriel/AAQ-5387-2020; Walss-Bass, Consuelo/K-5702-2015
OI Walss-Bass, Consuelo/0000-0003-2474-5448
FU St. Mary's University Undergraduate Research Office, Biaggini
   Undergraduate Research Scholarships, St. Mary's University; Department
   of Psychiatry, University of Texas Health Science Center at San Antonio
FX Summer Undergraduate Research Fellowship from the St. Mary's University
   Undergraduate Research Office, Biaggini Undergraduate Research
   Scholarships, St. Mary's University. Friends for Psychiatric Research
   Grant from the Department of Psychiatry, University of Texas Health
   Science Center at San Antonio. The funders had no role in study design,
   data collection and analysis, decision to publish, or preparation of the
   manuscript.
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NR 54
TC 69
Z9 76
U1 0
U2 20
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAR 20
PY 2013
VL 8
IS 3
AR e59012
DI 10.1371/journal.pone.0059012
PG 10
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 125SW
UT WOS:000317562600051
PM 23527073
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Yamanishi, K
   Hata, M
   Gamachi, N
   Watanabe, Y
   Yamanishi, C
   Okamura, H
   Matsunaga, H
AF Yamanishi, Kyosuke
   Hata, Masaki
   Gamachi, Naomi
   Watanabe, Yuko
   Yamanishi, Chiaki
   Okamura, Haruki
   Matsunaga, Hisato
TI Molecular Mechanisms of IL18 in Disease
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE interleukin 18; inflammasome; diabetes; dyslipidemia; metabolic
   syndrome; brown adipose tissue; hippocampus; depression; learning and
   memory; Alzheimer's disease
ID FATTY LIVER-DISEASE; MUSCARINIC M-1 RECEPTOR; INTERLEUKIN-18 LEVELS;
   DNA-DAMAGE; ATAXIA-TELANGIECTASIA; PLASMA INTERLEUKIN-18;
   ALZHEIMERS-DISEASE; INSULIN-RESISTANCE; IL-18 SECRETION; PROSTATE-CANCER
AB Interleukin 18 (IL18) was originally identified as an inflammation-induced cytokine that is secreted by immune cells. An increasing number of studies have focused on its non-immunological functions, with demonstrated functions for IL18 in energy homeostasis and neural stability. IL18 is reportedly required for lipid metabolism in the liver and brown adipose tissue. Furthermore, IL18 (Il18) deficiency in mice leads to mitochondrial dysfunction in hippocampal cells, resulting in depressive-like symptoms and cognitive impairment. Microarray analyses of Il18-/- mice have revealed a set of genes with differential expression in liver, brown adipose tissue, and brain; however, the impact of IL18 deficiency in these tissues remains uncertain. In this review article, we discuss these genes, with a focus on their relationships with the phenotypic disease traits of Il18-/- mice.
C1 [Yamanishi, Kyosuke; Matsunaga, Hisato] Hyogo Med Univ, Dept Neuropsychiat, 1-1 Mukogawa, Nishinomiya, Hyogo 6638501, Japan.
   [Yamanishi, Kyosuke; Hata, Masaki; Gamachi, Naomi; Okamura, Haruki; Matsunaga, Hisato] Hyogo Med Univ, Dept Psychoimmunol, 1-1 Mukogawa, Nishinomiya, Hyogo 6638501, Japan.
   [Watanabe, Yuko; Yamanishi, Chiaki] Hirakata Gen Hosp Dev Disorders, Hirakata, Osaka 5730122, Japan.
C3 Hyogo Medical University; Hyogo Medical University
RP Yamanishi, K (corresponding author), Hyogo Med Univ, Dept Neuropsychiat, 1-1 Mukogawa, Nishinomiya, Hyogo 6638501, Japan.; Yamanishi, K (corresponding author), Hyogo Med Univ, Dept Psychoimmunol, 1-1 Mukogawa, Nishinomiya, Hyogo 6638501, Japan.
EM k-yama@hyo-med.ac.jp; wyuko@gen-info.osaka-u.ac.jp;
   hirochan@hirakataryoiku-med.or.jp
RI Yamanishi, Kyosuke/GQH-4743-2022
OI Watanabe, Yuko/0000-0003-3706-5978; Matsunaga,
   Hisato/0000-0002-3724-3722
FU JSPS KAKENHI; Grants-in-Aid for Scientific Research [23K06999] Funding
   Source: KAKEN
FX We thank Nobutaka Okamura and Mina Nishimura for their technical
   support, Nobutaka Okamura for his assistance with animal care and the
   collection of samples, and Mina Nishimura for clerical assistance. We
   thank the funders listed above for supporting our study.
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NR 152
TC 14
Z9 15
U1 6
U2 17
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD DEC
PY 2023
VL 24
IS 24
AR 17170
DI 10.3390/ijms242417170
PG 16
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA DF9L9
UT WOS:001130731400001
PM 38139000
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Ebenezer, PJ
   Mariappan, N
   Elks, CM
   Haque, M
   Francis, J
AF Ebenezer, Philip J.
   Mariappan, Nithya
   Elks, Carrie M.
   Haque, Masudul
   Francis, Joseph
TI Diet-induced Renal Changes in Zucker Rats Are Ameliorated by the
   Superoxide Dismutase Mimetic TEMPOL
SO OBESITY
LA English
DT Article
ID HIGH-FAT DIETS; OXIDATIVE STRESS; METABOLIC SYNDROME;
   DIABETIC-NEPHROPATHY; INSULIN-RESISTANCE; HEART-FAILURE; MODEL; OBESITY;
   INJURY; SENSITIVITY
AB Diabetic nephropathy is the leading cause of renal failure in the United States. The obese Zucker rat (OZR; fa/fa) is a commonly used model of type 2 diabetes and metabolic syndrome (MetS), and of the nephropathy and renal oxidative stress commonly seen in these disorders. Heterozygous lean Zucker rats (LZRs; fa/+) are susceptible to high-fat diet (HFD)-induced obesity and MetS. The present study was designed to investigate whether 4-hydroxy-2,2,6,6-tetramethylpiperidine-N-oxyl (TEMPOL), a membrane-permeable radical scavenger, could alleviate the renal effects of MetS in OZR and LZR fed a HFD, which resembles the typical "Western" diet. OZR and LZR were fed a HFD (OZR-HFD and LZR-HFD) or regular diet (OZR-RD and LZR-RD) and allowed free access to drinking water or water containing 1 mmol/l TEMPOL for 10 weeks. When compared to OZR-RD animals, OZR-HFD animals exhibited significantly higher levels of total renal cortical reactive oxygen species (ROS) production, plasma lipids, insulin, C-reactive protein, blood urea nitrogen (BUN), creatinine (Cr), and urinary albumin excretion (P < 0.05); these changes were accompanied by a significant decrease in plasma high-density lipoprotein levels (P < 0.05). The mRNA expression levels of desmin, tumor necrosis factor-alpha (TNF-alpha), nuclear factor kappa B (NF kappa B), and NAD(P)H oxidase-1 (NOX-1) were significantly higher in the renal cortical tissues of OZR-HFD animals; NF kappa B p65 DNA binding activity as determined by electrophoretic mobility shift assay was also significantly higher in these animals. The same trends were noted in LZR-HFD animals. Our data demonstrate that TEMPOL may prove beneficial in treating the early stages of the nephropathy often associated with MetS.
C1 [Ebenezer, Philip J.; Mariappan, Nithya; Elks, Carrie M.; Haque, Masudul; Francis, Joseph] Louisiana State Univ, Sch Vet Med, Dept Comparat Biomed Sci, Baton Rouge, LA 70803 USA.
C3 Louisiana State University School of Veterinary Medicine; Louisiana
   State University System; Louisiana State University
RP Francis, J (corresponding author), Louisiana State Univ, Sch Vet Med, Dept Comparat Biomed Sci, Baton Rouge, LA 70803 USA.
RI Francis, Joseph/I-4984-2012; Elks, Carrie/N-1961-2017
OI Francis, Joseph/0000-0002-9502-4579
FU National Institutes of Health [1 RO1 HL080544-01]
FX We sincerely thank William G Henk, PhD, and Olga Borkhsenious, PhD for
   conducting transition electron microscopy studies The technical help of
   Sherry Ring is gratefully acknowledged These studies were supported by a
   grant from National Institutes of Health (1 RO1 HL080544-01) for J F
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Z9 71
U1 0
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1930-7381
EI 1930-739X
J9 OBESITY
JI Obesity
PD NOV
PY 2009
VL 17
IS 11
BP 1994
EP 2002
DI 10.1038/oby.2009.137
PG 9
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 512HT
UT WOS:000271237700007
PM 19424163
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Lavie, CJ
   Lee, JH
   Milani, RV
AF Lavie, Carl J.
   Lee, John H.
   Milani, Richard V.
TI Vitamin D and Cardiovascular Disease Will It Live Up to its Hype?
SO JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
LA English
DT Review
DE cardiovascular; disease; nutrition; vitamin D
ID PLACEBO-CONTROLLED TRIAL; D SUPPLEMENTATION; D DEFICIENCY; SERUM
   25-HYDROXYVITAMIN-D; CARDIAC REHABILITATION; PRIMARY
   HYPERPARATHYROIDISM; MYOCARDIAL-INFARCTION; MAJOR DEPRESSION;
   BLOOD-PRESSURE; HEART-DISEASE
AB Substantial evidence suggests that a large portion of the population have suboptimal levels of vitamin D, which may adversely affect the cardiovascular (CV) system, including increasing levels of parathyroid hormone, activating the renin-angiotensin-aldosterone system, and increasing insulin resistance, thus leading to hypertension and left ventricular hypertrophy, metabolic syndrome/diabetes mellitus, systemic inflammation, and increased risk of atherosclerosis and CV disease events. We review the evidence that vitamin D deficiency is associated with incident CV disease events, as well as evidence that vitamin D supplementation is associated with reduction in CV diseases. Although the current evidence has created substantial hype, randomized controlled trials are needed to determine whether routine vitamin D assessment and supplementation will improve CV outcomes. (J Am Coll Cardiol 2011;58:1547-56) (C) 2011 by the American College of Cardiology Foundation
C1 [Lavie, Carl J.; Lee, John H.; Milani, Richard V.] Univ Queensland, Sch Med, Exercise Labs,Dept Cardiovasc Dis, John Ochsner Heart & Vasc Inst,Ochsner Clin Sch, New Orleans, LA 70121 USA.
C3 Ochsner Health System; University of Queensland
RP Lavie, CJ (corresponding author), Univ Queensland, Sch Med, Exercise Labs,Dept Cardiovasc Dis, John Ochsner Heart & Vasc Inst,Ochsner Clin Sch, 1514 Jefferson Highway, New Orleans, LA 70121 USA.
EM clavie@ochsner.org
RI Lavie, Carl/A-6014-2011; Milani, Richard/AAS-7955-2020
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NR 77
TC 151
Z9 166
U1 0
U2 16
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0735-1097
EI 1558-3597
J9 J AM COLL CARDIOL
JI J. Am. Coll. Cardiol.
PD OCT 4
PY 2011
VL 58
IS 15
BP 1547
EP 1556
DI 10.1016/j.jacc.2011.07.008
PG 10
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 833FP
UT WOS:000295868000001
PM 21958881
OA Bronze
DA 2025-06-11
ER

PT J
AU Zidani, S
   Benakmoum, A
   Ammouche, A
   Benali, Y
   Bouhadef, A
   Abbeddou, S
AF Zidani, Sofiane
   Benakmoum, Amar
   Ammouche, Ali
   Benali, Yasmine
   Bouhadef, Anissa
   Abbeddou, Souheila
TI Effect of dry tomato peel supplementation on glucose tolerance, insulin
   resistance, and hepatic markers in mice fed
   high-saturated-fat/high-cholesterol diets
SO JOURNAL OF NUTRITIONAL BIOCHEMISTRY
LA English
DT Article
DE Dry tomato peel; Lycopene; High-saturated-fat/high-cholesterol diet;
   Mice; Glucose tolerance; Insulin resistance; Type 2 diabetes
ID CORONARY-HEART-DISEASE; FATTY LIVER-DISEASE; METABOLIC SYNDROME;
   ADIPOSE-TISSUE; OXIDATIVE STRESS; MESSENGER-RNA; LIPID PROFILE;
   VITAMIN-E; LYCOPENE; PLASMA
AB Many studies have investigated the effect of crude tomato peel in vivo, but no studies have determined the dose-effect of dry tomato peel (DTP) on glucose intolerance, insulin resistance, and atherogenic dyslipidemia induced by a high-saturated-fat (HSF) diet in vivo. The aim of this study was to investigate the effects of different doses of DTP on the levels of oxidative stress in mice fed an HSF and cholesterol-rich diet for 12 weeks. The main outcomes are glucose and insulin tolerance, plasma lipids, and hepatic steatosis and inflammation. BALB/c male mice (n=40) (8 weeks old, weighing 22.2 +/- 1.0 g) were divided into four treatment groups (10 mice/group): (a) high-fat control diet (HF Ctrl), which contains sunflower oil as a sole source of fat; (b) HSF/high-cholesterol (HC) diet; (c) HSF/HC diet supplemented with 9% DTP and (d) HSF/HC diet supplemented with 17% DTP. The HSF/HC diet significantly increased body weight gain, adipose tissue weight, fasting plasma glucose, fasting plasma insulin and lipid peroxidation and caused the development of liver steatosis and inflammation. Supplementation with DTP increased plasma lycopene concentration and reduced the development of indicators of metabolic syndrome, with no consistent effect of the DTP dose. Hepatic steatosis and inflammation were not reversed with DTP supplementation. Among mice fed the HSF/HC diet, DTP supplementation appears to have a beneficial effect on insulin resistance, which confirms the antiatherogenic effect of DTP. (C) 2016 Elsevier Inc. All rights reserved.
C1 [Zidani, Sofiane; Benakmoum, Amar] Univ Mhamed Bougara Boumerdes, Food Technol Res Lab, Boumerdes, Algeria.
   [Ammouche, Ali] Ecole Natl Super Agron, Food Technol & Human Nutr Dept, Algiers, Algeria.
   [Benali, Yasmine; Bouhadef, Anissa] Inst Pasteur, Biopathol & Genet Dept, Algiers, Algeria.
   [Abbeddou, Souheila] Univ Calif Davis, Dept Nutr, Program Int & Community Nutr, Davis, CA 95616 USA.
C3 Universite de M'hammed Bougara Boumerdes; Ecole Nationale Polytechnique
   - Algeria; University of California System; University of California
   Davis
RP Benakmoum, A (corresponding author), Univ Mhamed Bougara Boumerdes, Food Technol Res Lab, Boumerdes, Algeria.
EM benakmoum@gmail.com
OI Sofiane, ZIDANI/0000-0001-8903-1716; Abbeddou,
   Souheila/0000-0002-1363-0170
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NR 53
TC 21
Z9 21
U1 0
U2 34
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0955-2863
EI 1873-4847
J9 J NUTR BIOCHEM
JI J. Nutr. Biochem.
PD FEB
PY 2017
VL 40
BP 164
EP 171
DI 10.1016/j.jnutbio.2016.11.001
PG 8
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA EJ5KQ
UT WOS:000393257300019
PM 27907824
DA 2025-06-11
ER

PT J
AU Masrour, O
   Bardou-Jacquet, E
AF Masrour, Oumnia
   Bardou-Jacquet, Edouard
TI Current medical treatment for NAFLD/NASH
SO NUTRITION CLINIQUE ET METABOLISME
LA English
DT Review
DE MAFLD; NAFLD; NASH; Therapy
ID FATTY LIVER-DISEASE; RISK; PREVALENCE; DEPRESSION; FIBROSIS; TRIAL
AB Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide. The high prevalence of NAFLD is related to rising rates of obesity and metabolic syndrome. NAFLD prognosis is most closely linked with fibrosis stage, which can be assessed using non-invasive tests. Therapeutic endpoints include NASH resolution and fibrosis improvement. This hepatic endpoint must be integrated into the overall metabolic issue. Therapeutic strategy is based on lifestyle interventions and weight loss. Indeed, weight loss of 7-10% can reverse liver fibrosis, but adherence to lifestyle changes remains a major problem in real life. There are currently no approved pharmacological treatments for NASH. However, several therapeutic agents are rapidly progressing through the different phases of clinical trials. We provide a summary of recent therapeutic options with most advanced results.& COPY; 2023 Socie & PRIME;te & PRIME; francophone nutrition clinique et me & PRIME;tabolisme (SFNCM). Published by Elsevier Masson SAS. All rights reserved.
C1 [Masrour, Oumnia; Bardou-Jacquet, Edouard] CHU Rennes, Hop Pontchaillou, Serv Malad Foie, 2 Rue Henri Le Guilloux, F-35033 Rennes 9, France.
   [Bardou-Jacquet, Edouard] Univ Rennes, CHU Rennes, INSERM CIC1414, F-35000 Rennes, France.
   [Bardou-Jacquet, Edouard] CHU Rennes, Natl Reference Ctr Hemochromatosis & Iron Metab di, F-35000 Rennes, France.
C3 CHU Rennes; CHU Rennes; Institut National de la Sante et de la Recherche
   Medicale (Inserm); Universite de Rennes; Universite de Rennes; CHU
   Rennes
RP Bardou-Jacquet, E (corresponding author), CHU Rennes, Hop Pontchaillou, Serv Malad Foie, 2 Rue Henri Le Guilloux, F-35033 Rennes 9, France.; Bardou-Jacquet, E (corresponding author), Univ Rennes, CHU Rennes, INSERM CIC1414, F-35000 Rennes, France.; Bardou-Jacquet, E (corresponding author), CHU Rennes, Natl Reference Ctr Hemochromatosis & Iron Metab di, F-35000 Rennes, France.
EM Edouard.bardou-jacquet@chu-rennes.fr
RI Bardou-Jacquet, Edouard/E-6701-2013
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NR 32
TC 0
Z9 0
U1 6
U2 37
PU MASSON EDITEUR
PI MOULINEAUX CEDEX 9
PA 21 STREET CAMILLE DESMOULINS, ISSY, 92789 MOULINEAUX CEDEX 9, FRANCE
SN 0985-0562
EI 1768-3092
J9 NUTR CLIN METAB
JI Nutr. Clin. Metab.
PD MAY
PY 2023
VL 37
IS 2
BP 72
EP 76
DI 10.1016/j.nupar.2022.12.003
EA MAY 2023
PG 5
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA R0WM9
UT WOS:001061632900001
OA Bronze
DA 2025-06-11
ER

PT J
AU Zhao, GX
   Ford, ES
   Li, CY
   Tsai, J
   Dhingra, S
   Balluz, LS
AF Zhao, Guixiang
   Ford, Earl S.
   Li, Chaoyang
   Tsai, James
   Dhingra, Satvinder
   Balluz, Lina S.
TI Waist circumference, abdominal obesity, and depression among overweight
   and obese U.S. adults: national health and nutrition examination survey
   2005-2006
SO BMC PSYCHIATRY
LA English
DT Article
DE abdominal obesity; depressive symptoms; PHQ-9 diagnostic algorithm;
   waist circumference
ID BODY-MASS INDEX; METABOLIC SYNDROME; PSYCHIATRIC-DISORDERS;
   PHYSICAL-ACTIVITY; MENTAL-DISORDERS; FAT DISTRIBUTION; VISCERAL FAT;
   FOLLOW-UP; SYMPTOMS; ASSOCIATION
AB Background: Obesity is associated with an increased risk of mental illness; however, evidence linking body mass index (BMI)-a measure of overall obesity, to mental illness is inconsistent. The objective of this study was to examine the association of depressive symptoms with waist circumference or abdominal obesity among overweight and obese U.S. adults.
   Methods: A cross-sectional, nationally representative sample from the 2005-2006 National Health and Nutrition Examination Survey was used. We analyzed the data from 2,439 U.S. adults (1,325 men and 1,114 nonpregnant women) aged >= 20 years who were either overweight or obese with BMI of >= 25.0 kg/m(2). Abdominal obesity was defined as waist circumference of > 102 cm for men and > 88 cm for women. Depressive symptoms (defined as having major depressive symptoms or moderate-to-severe depressive symptoms) were assessed by the Patient Health Questionnaire-9 diagnostic algorithm. The prevalence and the odds ratios (ORs) with 95% confidence intervals (CIs) for having major depressive symptoms and moderate-to-severe depressive symptoms were estimated using logistic regression analysis.
   Results: After multivariate adjustment for demographics and lifestyle factors, waist circumference was significantly associated with both major depressive symptoms (OR: 1.03, 95% CI: 1.01-1.05) and moderate-to-severe depressive symptoms (OR: 1.02, 95% CI: 1.01-1.04), and adults with abdominal obesity were significantly more likely to have major depressive symptoms (OR: 2.18, 95% CI: 1.35-3.59) or have moderate-to-severe depressive symptoms (OR: 2.56, 95% CI: 1.34-4.90) than those without. These relationships persisted after further adjusting for coexistence of multiple chronic conditions and persisted in participants who were overweight (BMI: 25.0-< 30.0 kg/m(2)) when stratified analyses were conducted by BMI status.
   Conclusion: Among overweight and obese U.S. adults, waist circumference or abdominal obesity was significantly associated with increased likelihoods of having major depressive symptoms or moderate-to-severe depressive symptoms. Thus, mental health status should be monitored and evaluated in adults with abdominal obesity, particularly in those who are overweight.
C1 [Zhao, Guixiang; Ford, Earl S.; Tsai, James] Natl Ctr Chron Dis Prevent & Hlth Promot, Div Adult & Community Hlth, Atlanta, GA 30341 USA.
   [Li, Chaoyang; Dhingra, Satvinder; Balluz, Lina S.] Ctr Dis Control & Prevent, Div Behav Surveillance, Publ Hlth Surveillance Program Off, Off Surveillance Epidemiol & Lab Serv, Atlanta, GA 30341 USA.
C3 Centers for Disease Control & Prevention - USA; Centers for Disease
   Control & Prevention - USA; CDC Public Health Surveillance Program
   Office (PHSPO); CDC Office of Surveillance, Epidemiology & Laboratory
   Services (OSELS)
RP Zhao, GX (corresponding author), Natl Ctr Chron Dis Prevent & Hlth Promot, Div Adult & Community Hlth, Atlanta, GA 30341 USA.
EM fwj4@cdc.gov
RI Tsai, James/G-4541-2012
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NR 56
TC 117
Z9 123
U1 1
U2 26
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-244X
J9 BMC PSYCHIATRY
JI BMC Psychiatry
PD AUG 11
PY 2011
VL 11
AR 130
DI 10.1186/1471-244X-11-130
PG 9
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 814GN
UT WOS:000294436400001
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Khan, S
   Duan, PF
   Yao, LG
   Hou, HW
AF Khan, Suliman
   Duan, Pengfei
   Yao, Lunguang
   Hou, Hongwei
TI Shiftwork-Mediated Disruptions of Circadian Rhythms and Sleep
   Homeostasis Cause Serious Health Problems
SO INTERNATIONAL JOURNAL OF GENOMICS
LA English
DT Review
ID MAJOR DEPRESSIVE DISORDER; CHRONIC JET-LAG; METABOLIC SYNDROME;
   RISK-FACTOR; PREVENTS OBESITY; CANCER-RISK; FOOD-INTAKE; WORK; GENE;
   POLYMORPHISM
AB Shiftwork became common during the last few decades with the growing demands of human life. Despite the social inactivity and irregularity in habits, working in continuous irregular shifts causes serious health issues including sleep disorders, psychiatric disorders, cancer, and metabolic disorders. These health problems arise due to the disruption in circadian clock system, which is associated with alterations in genetic expressions. Alteration in clock controlling genes further affects genes linked with disorders including major depression disorder, bipolar disorder, phase delay and phase advance sleep syndromes, breast cancer, and colon cancer. A diverse research work is needed focusing on broad spectrum changes caused by jet lag in brain and neuronal system. This review is an attempt to motivate the researchers to conduct advanced studies in this area to identify the risk factors and mechanisms. Its goal is extended to make the shift workers aware about the risks associated with shiftwork.
C1 [Khan, Suliman; Hou, Hongwei] Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan 430072, Hubei, Peoples R China.
   [Duan, Pengfei; Yao, Lunguang] Nanyang Normal Univ, Coll Agr Engn, Collaborat Innovat Ctr Water & Secur Water Source, South To North Divers Project, Nanyang, Henan, Peoples R China.
C3 Chinese Academy of Sciences; Institute of Hydrobiology, CAS; Nanyang
   Normal College
RP Hou, HW (corresponding author), Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan 430072, Hubei, Peoples R China.; Yao, LG (corresponding author), Nanyang Normal Univ, Coll Agr Engn, Collaborat Innovat Ctr Water & Secur Water Source, South To North Divers Project, Nanyang, Henan, Peoples R China.
EM lunguangyao@163.com; houhw@ihb.ac.cn
RI Hou, Hongwei/LIG-2912-2024; khan, suliman/S-3492-2017
OI Hou, Hongwei/0000-0003-4823-0270; Khan, Suliman/0000-0003-4954-0748
FU National Natural Science Foundation of China [31372381]; Henan
   Scientific and Technological Innovation Team Fund [17454]; Chinese
   Academy of Science and The World Academy of Science (CAS-TWAS)
   scholarship program
FX This work was supported by the National Natural Science Foundation of
   China (Grant no. 31372381) and the Henan Scientific and Technological
   Innovation Team Fund (17454). The authors are thankful to the Chinese
   Academy of Science and The World Academy of Science (CAS-TWAS)
   scholarship program.
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NR 120
TC 73
Z9 84
U1 0
U2 37
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2314-436X
EI 2314-4378
J9 INT J GENOMICS
JI Int. J. Genomics
PY 2018
VL 2018
AR 8576890
DI 10.1155/2018/8576890
PG 11
WC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
   Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
   Genetics & Heredity
GA FV3HH
UT WOS:000424458200001
PM 29607311
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Farley, E
   Menter, A
AF Farley, E.
   Menter, A.
TI Psoriasis: comorbidities and associations
SO GIORNALE ITALIANO DI DERMATOLOGIA E VENEREOLOGIA
LA English
DT Article
DE Psoriasis; Autoimmune diseases; Skin diseases
ID EVIDENT CARDIOVASCULAR-DISEASE; FATTY LIVER-DISEASE; RISK-FACTORS;
   ARTHRITIS PATIENTS; METABOLIC SYNDROME; PLAQUE PSORIASIS;
   CORONARY-ARTERY; NURSES HEALTH; PHASE-III; T-CELLS
AB Psoriasis is a chronic, genetic, inflammatory skin disease affecting approximately 2% of the population worldwide. Over the past decade, multiple studies have shown that not only is there an association between psoriasis and psoriatic arthritis, depression, and substance abuse, but psoriasis patients also have a higher incidence of obesity, diabetes, heart disease and stroke. In addition, and more concerning, young psoriatic patients particularly those with more severe disease are at an increased mortality risk even when controlling for these factors. The systemic inflammation in psoriasis generates elevation of C-reactive protein, homocysteine, and inflammatory cytokines such as TNF-alpha, IL-6, IL-17, IL-20, IL-22, and IL-23, which may contribute to the overall morbidity and mortality in these patients. Within this article we will discuss the associations between psoriasis and multiple systemic health problems.
C1 [Farley, E.; Menter, A.] Baylor Univ, Dept Dermatol, Med Ctr, Dallas, TX 75246 USA.
C3 Baylor University Medical Center; Baylor University
RP Menter, A (corresponding author), Baylor Univ, Dept Dermatol, Med Ctr, 3900 Junius St, Dallas, TX 75246 USA.
EM amderm@gmail.com
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NR 78
TC 78
Z9 83
U1 0
U2 11
PU EDIZIONI MINERVA MEDICA
PI TURIN
PA CORSO BRAMANTE 83-85 INT JOURNALS DEPT., 10126 TURIN, ITALY
SN 0392-0488
EI 1827-1820
J9 GIORN ITAL DERMAT V
JI G. Ital. Dermatol. Venereol.
PD FEB
PY 2011
VL 146
IS 1
BP 9
EP 15
PG 7
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 725ZL
UT WOS:000287685300002
PM 21317853
DA 2025-06-11
ER

PT J
AU Holst, MM
   Wirth, MD
   Mnatsakanova, A
   Burch, JB
   Charles, LE
   Tinney-Zara, C
   Fekedulegn, D
   Andrew, ME
   Hartley, TA
   Violanti, JM
AF Holst, Meghan M.
   Wirth, Michael D.
   Mnatsakanova, Anna
   Burch, James B.
   Charles, Luenda E.
   Tinney-Zara, Cathy
   Fekedulegn, Desta
   Andrew, Michael E.
   Hartley, Tara A.
   Violanti, John M.
TI Shiftwork and Biomarkers of Subclinical Cardiovascular Disease The
   BCOPS Study
SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
LA English
DT Article
DE cardiovascular disease; inflammation; police work; shiftwork
ID BLOOD-CELL COUNT; RISK-FACTORS; INFLAMMATORY MARKERS; METABOLIC
   SYNDROME; POLICE OFFICERS; HEART-DISEASE; NIGHT WORK; SLEEP;
   ATHEROSCLEROSIS; DEPRESSION
AB Objective: To assess the association of shiftwork with biomarkers of subclinical cardiovascular disease and examine the moderating role of body mass index (BMI) in a police cohort. Methods: A cross-sectional analysis was conducted among officers who were categorized as working the day, evening, or night shift. Comparisons with inflammatory biomarkers were performed among shifts using analysis of variance/covariance and further stratified by BMI to assess potential effect modification. Results: Associations were observed between day and night shiftworkers for leukocytes, tumor necrosis factor alpha, and homocysteine. After BMI stratification, higher c-reactive protein (CRP) levels were observed among evening shiftworkers with a BMI more than or equal to 30 kg/m(2) versus the day shift. Conclusions: Future studies examining prospective changes in these markers will allow for more comprehensive evaluation of their association with shiftwork.
C1 [Holst, Meghan M.; Wirth, Michael D.; Burch, James B.] Univ South Carolina, Dept Epidemiol & Biostat, Arnold Sch Publ Hlth, Columbia, SC 29208 USA.
   [Wirth, Michael D.; Burch, James B.] Univ South Carolina, Canc Prevent & Control Program, 915 Greene St,Room 233, Columbia, SC 29208 USA.
   [Wirth, Michael D.] Univ South Carolina, Coll Nursing, Columbia, SC 29208 USA.
   [Mnatsakanova, Anna; Charles, Luenda E.; Tinney-Zara, Cathy; Fekedulegn, Desta; Andrew, Michael E.; Hartley, Tara A.] Ctr Dis Control & Prevent, Biostat & Epidemiol Branch, Hlth Effects Lab Div, NIOSH, Morgantown, WV USA.
   [Burch, James B.] WJB Dorn VA Med Ctr, Columbia, SC USA.
   [Violanti, John M.] SUNY Buffalo, Dept Epidemiol & Environm Hlth, Sch Publ Hlth & Hlth Profess, Buffalo, NY USA.
C3 University of South Carolina System; University of South Carolina
   Columbia; University of South Carolina System; University of South
   Carolina Columbia; University of South Carolina System; University of
   South Carolina Columbia; Centers for Disease Control & Prevention - USA;
   National Institute for Occupational Safety & Health (NIOSH); State
   University of New York (SUNY) System; University at Buffalo, SUNY
RP Wirth, MD (corresponding author), Univ South Carolina, Canc Prevent & Control Program, 915 Greene St,Room 233, Columbia, SC 29208 USA.
EM wirthm@mailbox.sc.edu
RI Wirth, Michael/C-6330-2013; Charles, Luenda/H-6008-2011
OI Holst, Meghan/0000-0002-9505-7282
FU National Institute for Occupational Safety and Health (NIOSH)
   [200-2003-01580, 254-2012-M53230, 200-2014-M-60325]
FX This work was supported by the National Institute for Occupational
   Safety and Health (NIOSH), NIOSH contract numbers 200-2003-01580,
   254-2012-M53230, and 200-2014-M-60325. The findings and conclusions are
   those of the authors and do not necessarily represent the official
   position of the National Institute for Occupational Safety and Health,
   Centers for Disease Control and Prevention.
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NR 45
TC 11
Z9 13
U1 1
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1076-2752
EI 1536-5948
J9 J OCCUP ENVIRON MED
JI J. Occup. Environ. Med.
PD MAY
PY 2019
VL 61
IS 5
BP 391
EP 396
DI 10.1097/JOM.0000000000001541
PG 6
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA IQ5FY
UT WOS:000480778700015
PM 30649009
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Patlola, SR
   Donohoe, G
   McKernan, DP
AF Patlola, Saahithh Redddi
   Donohoe, Gary
   McKernan, Declan P.
TI The relationship between inflammatory biomarkers and cognitive
   dysfunction in patients with schizophrenia: A systematic review and
   meta-analysis
SO PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
LA English
DT Review
DE Schizophrenia; Cognition; Cytokine; Inflammation; meta-analysis
ID C-REACTIVE PROTEIN; METABOLIC SYNDROME; CYTOKINES; INTERLEUKIN-1-BETA;
   ANTIPSYCHOTICS; ASSOCIATION; SYMPTOMS; DECLINE
AB Background: Schizophrenia is a complex psychiatric disorder that includes positive and negative symptoms but also debilitating cognitive deficits. Current pharmacological interventions do not target these deficits. Recent evidence suggests a connection between some inflammatory markers (including C-reactive protein) and cognitive impairment, but did not address other inflammatory markers. In the current study, we try to fill the gap by focusing on the association of Interleukin-6 (IL-6), IL-113, Tumor Necrosis Factor-alpha and CRP with cognitive dysfunction.Methods: PUBMED and Web of Science databases were searched for all studies published until July 2022. A total of 25 studies were included in an analysis of the association between cognitive performance and variation in IL-6, IL-113, TNF-alpha and CRP.Results: A total of 2398 patients were included in this study. Meta-analyses results showed a significant inverse relationship between performance in five cognitive domains (attention-processing speed, executive function, working memory, verbal and visual learning and memory) and systemic IL-6, IL-113, TNF-alpha and CRP plasma levels in patients with schizophrenia. The meta-analyses results showed a significant decline in the cognitive perfor-mances with the evaluated inflammatory markers with effect sizes ranging from-0.136 to-0.181 for IL-6,-0.188 to-0.38 for TNF-alpha-0.372 to-0.476 for IL-113 and -0.168 to-0.311 for CRP.Conclusion: Findings from the current study shows that cognitive deficits are reflective of elevated proin-flammatory biomarkers (IL-6, IL-113, TNF-alpha and CRP) levels. The results obtained indicate relatedness between inflammation and cognitive decline in patients with schizophrenia. Understanding the underlying pathways between them could have a significant impact on the disease progression and quality of life in schizophrenia patients.
C1 [Patlola, Saahithh Redddi; McKernan, Declan P.] Natl Univ Ireland Galway, Sch Med Pharmacol & Therapeut, Galway, Ireland.
   [Donohoe, Gary] Natl Univ Ireland Galway, Sch Psychol, Galway, Ireland.
C3 Ollscoil na Gaillimhe-University of Galway; Ollscoil na
   Gaillimhe-University of Galway
RP McKernan, DP (corresponding author), Natl Univ Ireland Galway, Sch Med Pharmacol & Therapeut, Galway, Ireland.
EM Declan.mckernan@nuigalway.ie
RI Patlola, Saahithh Redddi/KDN-9990-2024; Donohoe, Gary/J-6481-2013;
   McKernan, Declan/AEK-0857-2022
OI Patlola, Saahithh Redddi/0000-0003-4367-1720; McKernan,
   Declan/0000-0002-9691-1671
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NR 74
TC 60
Z9 61
U1 2
U2 51
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0278-5846
EI 1878-4216
J9 PROG NEURO-PSYCHOPH
JI Prog. Neuro-Psychopharmacol. Biol. Psychiatry
PD MAR 8
PY 2023
VL 121
AR 110668
DI 10.1016/j.pnpbp.2022.110668
EA OCT 2022
PG 13
WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA 6C5RQ
UT WOS:000882071600003
PM 36283512
DA 2025-06-11
ER

PT J
AU Hattori, Y
   Akimoto, K
   Gross, SS
   Hattori, S
   Kasai, K
AF Hattori, Y
   Akimoto, K
   Gross, SS
   Hattori, S
   Kasai, K
TI RETRACTED: Angiotensin-II-induced oxidative stress elicits
   hypoadiponectinaemia in rats (Retracted article. See vol. 54, pg. 2475,
   2011)
SO DIABETOLOGIA
LA English
DT Article; Retracted Publication
DE adiponectin; angiotensin II; metabolic syndrome; oxidative stress;
   tempol; tetrahydrobiopterin
ID VASCULAR SMOOTH-MUSCLE; PLASMA-PROTEIN ADIPONECTIN; ADIPOSE-SPECIFIC
   PROTEIN; NADPH OXIDASE ACTIVITY; NF-KAPPA-B; ENDOTHELIAL DYSFUNCTION;
   NAD(P)H OXIDASE; CARDIOVASCULAR MORBIDITY; ESSENTIAL-HYPERTENSION;
   HORMONAL-REGULATION
AB Hypertension, endothelial dysfunction and insulin resistance are associated conditions that share oxidative stress and vascular inflammation as common features. Adiponectin is an abundant plasma adipokine that plays a physiological role in modulating lipid metabolism and exerts a potent anti-inflammatory activity. We hypothesised that adiponectin levels decrease in response to oxidative stress and that this may promote the development of hypertension, endothelial dysfunction and insulin resistance. Rats were infused with angiotensin II (AngII) or its vehicle, either alone or in combination with tempo1 (4-hydroxy-2,2,6,6-tetramethyl piperidinoxyl), a membrane-permeable metal-independent superoxide dismutase mimetic, or tetrahydrobiopterin (BH4), one of the most potent naturally occurring reducing agents and an essential cofactor for nitric oxide synthase activity. Heart rate, systolic blood pressure, body weight and serum levels of adiponectin were measured on day 7 of treatment, and then the animals were killed. Vessel tone and superoxide production were measured ex vivo in thoracic vascular rings. The expression of adiponectin mRNA in adipose tissue was assessed by Northern blotting, and in 3T3-L1 adipocytes exposed to H2O2 by real-time PCR. The expression of NAD(P)H oxidase subunit mRNAs in the rats was assessed by RT-PCR and real-time PCR. Hypertension and endothelial dysfunction were induced in rats by infusion of AngII and reversed by administration of tempol. Plasma concentrations of adiponectin and adipose tissue levels of adiponectin mRNA were decreased in AngII-infused rats, and this effect was prevented by cotreatment with tempol or BH4. The production of superoxide anions (O-2(-)) was significantly increased in the aortae of AngII-treated rats, and this increase was prevented by the administration of tempol or BH4. Levels of mRNAs that encode NAD(P)H oxidase components, including p22phox, gp91phox, p47phox and Rac1, were similarly increased in adipose tissue, aortae and hearts of AngII-infused rats. Cotreatment of rats with tempol or BH4 reversed AngII-induced increases in NAD(P)H oxidase subunit mRNAs. Fully differentiated 3T3-L1 adipocytes, also exhibited diminished adiponectin mRNA levels when exposed to low concentrations of H2O2. Our results demonstrate that AngII-induced oxidative stress and endothelial dysfunction are accompanied by a decrease in adiponectin gene expression. Since antioxidants were observed to prevent the actions of AngII, and H2O2 on its own suppressed adiponectin expression, we conclude that adiponectin gene expression is negatively modulated by oxidative stress. Plasma adiponectin levels may provide a useful indicator of oxidative stress in vivo, and suppressed levels may contribute to the proinflammatory and metabolic derangements associated with type 2 diabetes, coronary artery disease and the metabolic syndrome.
C1 Dokkyo Univ, Sch Med, Dept Endocrinol & Metab, Mibu, Tochigi 3210293, Japan.
   Dokkyo Univ, Sch Med, Mol & Cellular Biol Lab, Mibu, Tochigi, Japan.
   Cornell Univ, Weill Med Coll, Dept Pharmacol, New York, NY USA.
   Cornell Univ, Weill Med Coll, Program Biochem & Struct Biol, New York, NY USA.
C3 Dokkyo Medical University; Dokkyo Medical University; Cornell
   University; Weill Cornell Medicine; Cornell University; Weill Cornell
   Medicine
RP Dokkyo Univ, Sch Med, Dept Endocrinol & Metab, Mibu, Tochigi 3210293, Japan.
EM yhattori@dokkyomed.ac.jp
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NR 43
TC 96
Z9 113
U1 0
U2 14
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0012-186X
EI 1432-0428
J9 DIABETOLOGIA
JI Diabetologia
PD JUN
PY 2005
VL 48
IS 6
BP 1066
EP 1074
DI 10.1007/s00125-005-1766-7
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 936RU
UT WOS:000229873900006
PM 15864528
OA Bronze
DA 2025-06-11
ER

PT J
AU Cersosimo, E
   DeFronzo, RA
AF Cersosimo, Eugenio
   DeFronzo, Ralph A.
TI Insulin resistance and endothelial dysfunction: the road map to
   cardiovascular diseases
SO DIABETES-METABOLISM RESEARCH AND REVIEWS
LA English
DT Review
DE insulin action; insulin resistance; vascular endothelium; vascular
   physiology; endothelial dysfunction; cardiovascular diseases;
   atherosclerosis
ID CHOLESTEROL-LOWERING THERAPY; SKELETAL-MUSCLE VASODILATION; MEDIATED
   GLUCOSE-UPTAKE; NITRIC-OXIDE SYNTHASE; BLOOD-FLOW; MICROVASCULAR
   RECRUITMENT; RISK-FACTORS; CORONARY ENDOTHELIUM; DEPENDENT RELAXATION;
   VASCULAR REACTIVITY
AB Cardiovascular disease affects approximately 60% of the adult population over the age of 65 and represents the number one cause of death in the United States. Coronary atherosclerosis is responsible for the vast majority of the cardiovascular events, and a number of cardiovascular risk factors have been identified. in recent years, it has become clear that insulin resistance and endothelial dysfunction play a central role in the pathogenesis of atherosclerosis. Much evidence supports the presence of insulin resistance as the fundamental pathophysiologic disturbance responsible for the cluster of metabolic and cardiovascular disorders, known collectively as the metabolic syndrome. Endothelial dysfunction is an important component of the metabolic or insulin resistance syndrome and this is demonstrated by inadequate vasodilation and/or paradoxical vasoconstriction in coronary and peripheral arteries in response to stimuli that release nitric oxide (NO). Deficiency of endothelial-derived NO is believed to be the primary defect that links insulin resistance and endothelial dysfunction. NO deficiency results from decreased synthesis and/or release, in combination with exaggerated consumption in tissues by high levels of reactive oxygen (ROS) and nitrogen (RNS) species, which are produced by cellular disturbances in glucose and lipid metabolism.
   Endothelial dysfunction contributes to impaired insulin action, by altering the transcapillary passage of insulin to target tissues. Reduced expansion of the capillary network, with attenuation of microcirculatory blood flow to metabolically active tissues, contributes to the impairment of insulin-stimulated glucose and lipid metabolism. This establishes a reverberating negative feedback cycle in which progressive endothelial dysfunction and disturbances in glucose and lipid metabolism develop secondary to the insulin resistance. Vascular damage, which results from lipid deposition and oxidative stress to the vessel wall, triggers an inflammatory reaction, and the release of chemoattractants and cytokines worsens the insulin resistance and endothelial dysfunction.
   From the clinical standpoint, much experimental evidence supports the concept that therapies that improve insulin resistance and endothelial dysfunction reduce cardiovascular morbidity and mortality. Moreover, interventional strategies that reduce insulin resistance ameliorate endothelial dysfunction, while interventions that improve tissue sensitivity to insulin enhance vascular endothelial function. There is general agreement that aggressive therapy aimed simultaneously at improving insulin-mediated glucose/lipid metabolism and endothelial dysfunction represents an important strategy in preventing/delaying the appearance of atherosclerosis. Interventions that [1] correct carbohydrate and lipid metabolism, [2] improve insulin resistance, [3] reduce blood pressure and restore vascular reactivity, and [4] attenuate procoagulant and inflammatory responses in adults with a high risk of developing cardiovascular disease reduce cardiovascular morbidity and mortality. Whether these benefits hold when the same prevention strategies are applied to younger, high-risk individuals remains to be determined. Copyright (c) 2006 John Wiley & Sons, Ltd.
C1 Univ Texas, Hlth Sci Ctr, Div Diabet, Dept Med, San Antonio, TX 78229 USA.
C3 University of Texas System; University of Texas Health Science Center at
   San Antonio
RP Cersosimo, E (corresponding author), Univ Texas, Hlth Sci Ctr, Div Diabet, Dept Med, 7703 Floyd Curl Dr,Mail Code 7886, San Antonio, TX 78229 USA.
EM Eugenio.Cersosimo@uhs-sa.com
RI Cersosimo, Eugenio/LMD-2715-2024
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NR 120
TC 357
Z9 403
U1 0
U2 31
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1520-7552
EI 1520-7560
J9 DIABETES-METAB RES
JI Diabetes-Metab. Res. Rev.
PD NOV-DEC
PY 2006
VL 22
IS 6
BP 423
EP 436
DI 10.1002/dmrr.634
PG 14
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 110BX
UT WOS:000242354400001
PM 16506274
DA 2025-06-11
ER

PT J
AU Filipcic, IS
   Filipcic, I
AF Filipcic, Ivona Simunovic
   Filipcic, Igor
TI SCHIZOPHRENIA AND PHYSICAL COMORBIDITY
SO PSYCHIATRIA DANUBINA
LA English
DT Article
DE schizophrenia spectrum disorder; psychosis; serious mental illness;
   comorbidity; general medical condition; major noncommunicable disease
ID SERIOUS MENTAL-ILLNESS; METABOLIC SYNDROME; SMOKING-CESSATION; GLOBAL
   BURDEN; HEALTH-CARE; DISORDERS; PEOPLE; MORTALITY; RISK; DISEASE
AB Schizophrenia is a severe psychiatric disorder increasingly recognized as a systemic disorder. In addition to the burden and suffering caused by the mental illness itself, individuals with schizophrenia have a high risk for physical illnesses. The life expectancy gap remains 13 to 30 years wider in people with schizophrenia compared to the general population. This premature mortality is caused largely by deaths due to cardiovascular disease, cancer, diabetes mellitus, and other natural causes, poor diagnosis and treatment, and insufficient prevention of modifiable risk factors. Although the links between schizophrenia and physical illnesses are well established, in clinical practice, physical illnesses in patients with schizophrenia are often overlooked, and the mortality gap between general population and people with schizophrenia continues to widen. The physical health of people with schizophrenia is commonly self-neglected but also ignored by people around them and by health systems, resulting in significant physical health disparities and limited access to health services. The root of the problem of insufficient healthcare appear to lie in interrelated contributory factors from illness, patients, and medical and mental healthcare system. Furthermore, a growing body of literature has been indicating the effect of the chronic physical illness on the treatment outcome of psychosis. Premature mortality and disability could be reduced if there was a greater focus on the implementation of strategies that effectively prevent modifiable risk factors from the first psychotic episode and enhance early recognition of physical illnesses, reduce the burden of physical comorbidity and lead to improved health outcomes. Ultimately, to improve treatment outcome and to reduce the suffering of people with schizophrenia, it is crucial to treat physical comorbidity promptly and assertively from the appearance of the first symptoms of the psychotic disorder. The integrative approach and collaborative care within all levels of healthcare providers should be the imperative in clinical practice.
C1 [Filipcic, Ivona Simunovic; Filipcic, Igor] Univ Hosp Ctr Zagreb, Dept Psychol Med, Kispaticeva 12, HR-10000 Zagreb, Croatia.
   [Filipcic, Igor] Psychiat Hosp Sveti Ivan, Zagreb, Croatia.
   [Filipcic, Igor] Josip Juraj Strossmayer Univ Osijek, Fac Dent Med & Hlth, Osijek, Croatia.
   [Filipcic, Igor] Univ Zagreb, Sch Med, Zagreb, Croatia.
C3 University of Zagreb; UNIVERSITY ZAGREB HOSPITAL; University of JJ
   Strossmayer Osijek; University of Zagreb
RP Filipcic, IS (corresponding author), Univ Hosp Ctr Zagreb, Dept Psychol Med, Kispaticeva 12, HR-10000 Zagreb, Croatia.
EM ivonasf@gmail.com
RI Filipčić, Igor/ABA-8542-2020; Filipčić, Ivona/AAC-8790-2019
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NR 54
TC 10
Z9 10
U1 0
U2 3
PU MEDICINSKA NAKLADA
PI ZAGREB
PA VLASKA 69, HR-10000 ZAGREB, CROATIA
SN 0353-5053
EI 1849-0867
J9 PSYCHIAT DANUB
JI Psychiatr. Danub.
PY 2018
VL 30
SU 4
BP S152
EP S157
PG 6
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA GU8UN
UT WOS:000445618200001
DA 2025-06-11
ER

PT J
AU Zhang, LL
   Lai, Y
   Yan, L
   Fang, JP
   Wang, K
AF Zhang, Lingling
   Lai, Yi
   Yan, Long
   Fang, Jiaping
   Wang, Kai
TI The joint and interactive effects of the non-high-density lipoprotein
   cholesterol to high-density lipoprotein cholesterol ratio (NHHR) and
   body mass index on the risk of depression, as well as the mediating role
   of NHHR: results from NHANES 2005-2023
SO LIPIDS IN HEALTH AND DISEASE
LA English
DT Article
DE NHHR; BMI; Depression; NHANES; Interaction; Mediation effect
ID HEALTH QUESTIONNAIRE-9 PHQ-9; TNF-ALPHA; MENDELIAN RANDOMIZATION;
   METABOLIC SYNDROME; PRIMARY-CARE; OBESITY; METAANALYSIS; ASSOCIATION;
   DYSLIPIDEMIA; DISORDER
AB BackgroundVarious research in the past has indicated that the NHHR, which represents the ratio of non-high-density lipoprotein cholesterol (non-HDL-C) to high-density lipoprotein cholesterol (HDL-C), and body mass index (BMI) each act independently as contributors to depression risk. Nonetheless, studies exploring the combination of NHHR with BMI in relation to depression are limited. Consequently, the central aim of this study is investigating the joint and interactive effects of NHHR and BMI on depression risk, as well as the mediating role of NHHR.MethodsEncompassing participants aged 20 years or over, this research incorporated a total of 39,704 individuals from the National Health and Nutrition Examination Survey (NHANES), which covered the period of 2005 to 2023. To analyze the impact of NHHR and its combination with BMI on depression, our analytical approach included multivariate logistic regression, restricted cubic spline modeling, interaction testing and subgroup analyses. Additionally, we studied the joint effects of NHHR and BMI. Finally, we applied a four-way decomposition analysis method to examine the interactions and mediating effects within the aforementioned relationships.ResultsAmong all participants in this study, the prevalence of depressive disorder (Patient Health Questionnaire-9 score >= 10) was 9.2%. Both the NHHR and BMI were associated with depression, which remained significant even after full adjustment for covariates [NHHR, OR (95% CI): 1.07 (1.04-1.09); BMI, OR (95% CI): 1.02 (1.02-1.03)]. Compared with the reference group, the OR (95% CI) for the highest groups of NHHR, BMI, and their product term NHHR-BMI were 1.41 (1.24-1.61), 1.35 (1.18-1.54), and 1.59 (1.37-1.84), respectively. Participants with NHHR in the fourth quartile and BMI exceeding 30 kg/m(2), had higher depression risk compared to other participants with NHHR in the first quartile and BMI below 25 kg/m(2) [OR (95% CI): 1.64 (1.34-2.00)]. Results of the four-way decomposition analyses indicated that NHHR played a mediating role in the association between BMI and depression, with the mediating effect accounting for 17.6%. Similarly, NHHR also mediated 11.0% of the mediating effect between BMI and PHQ-9 score. However, no interaction between NHHR and BMI related to depression was found in the general population. After stratifying by gender, it was found that the mediated interaction between NHHR and BMI had a statistically significant effect on depression and PHQ-9 score in males.ConclusionsDepression risk is linked to both NHHR and BMI, and NHHR has a significant mediating impact on the association between BMI and depression. Notably, there is a non-negligible mediated interaction effect between BMI and NHHR in male participants. Compared to considering NHHR or BMI individually, participants had a higher risk of depression when the combined terms of the two were in the higher quartiles. These findings suggest that the combined assessment of these two indicators may help deepen the understanding and evaluation of depression, enhance the accuracy of risk stratification, and is worthy of further research.
C1 [Zhang, Lingling] Wenzhou Med Univ, Peoples Hosp Xiaoshan Dist 1, Dept Clin Lab, Xiaoshan Affiliated Hosp, Hangzhou 311200, Zhejiang, Peoples R China.
   [Lai, Yi; Yan, Long; Fang, Jiaping; Wang, Kai] Wenzhou Med Univ, Peoples Hosp Xiaoshan Dist 1, Dept Emergency, Xiaoshan Affiliated Hosp, Hangzhou 311200, Zhejiang, Peoples R China.
C3 Wenzhou Medical University; Wenzhou Medical University
RP Wang, K (corresponding author), Wenzhou Med Univ, Peoples Hosp Xiaoshan Dist 1, Dept Emergency, Xiaoshan Affiliated Hosp, Hangzhou 311200, Zhejiang, Peoples R China.
EM kwemergency@163.com
FU National Center for Health Statistics of the Centers for Disease Control
   and Prevention
FX We express our sincere gratitude to the National Center for Health
   Statistics of the Centers for Disease Control and Prevention for
   providing the NHANES dataset. The rich information contained within
   NHANES has been instrumental in conducting this research. We appreciate
   the dedications and endeavors of the NHANES staff in gathering and
   preserving high-quality data, which has greatly contributed to the
   reliability and validity of this study.
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NR 83
TC 2
Z9 2
U1 10
U2 10
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1476-511X
J9 LIPIDS HEALTH DIS
JI Lipids Health Dis.
PD FEB 28
PY 2025
VL 24
IS 1
AR 77
DI 10.1186/s12944-025-02493-x
PG 16
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA Y8H2A
UT WOS:001434455800001
PM 40022090
OA gold
DA 2025-06-11
ER

PT J
AU Liang, Y
   Wang, MX
   Wang, C
   Liu, Y
   Naruse, K
   Takahashi, K
AF Liang, Yin
   Wang, Mengxue
   Wang, Chen
   Liu, Yun
   Naruse, Keiji
   Takahashi, Ken
TI The Mechanisms of the Development of Atherosclerosis in Prediabetes
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE prediabetes; atherosclerosis; metabolic syndrome; obesity; endothelial
   dysfunction; exosome; microRNA
ID PLATELET-DERIVED MICROPARTICLES; PERIVASCULAR ADIPOSE-TISSUE;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; STEM-CELLS; EXTRACELLULAR
   VESICLES; CARDIOVASCULAR-DISEASE; DIABETES-MELLITUS; GLUCOSE-TOLERANCE;
   GLYCEMIC STATUS
AB Lifestyle changes, such as overeating and underexercising, can increase the risk of prediabetes. Diabetes is one of the leading causes of atherosclerosis, and recently it became clear that the pathophysiology of atherosclerosis progresses even before the onset of diabetic symptoms. In addition to changes in platelets and leukocytes in the hyperglycemic state and damage to vascular endothelial cells, extracellular vesicles and microRNAs were found to be involved in the progression of prediabetes atherosclerosis. This review discusses the cellular and molecular mechanisms of these processes, with an intention to enable a comprehensive understanding of the pathophysiology of prediabetes and atherosclerosis.
C1 [Liang, Yin; Wang, Mengxue; Wang, Chen; Liu, Yun; Naruse, Keiji; Takahashi, Ken] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Cardiovasc Physiol, Okayama 7008558, Japan.
C3 Okayama University
RP Takahashi, K (corresponding author), Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Cardiovasc Physiol, Okayama 7008558, Japan.
EM pqjj7wl7@s.okayama-u.ac.jp; pmws31d7@s.okayama-u.ac.jp;
   pneq0ew8@s.okayama-u.ac.jp; pkfh3lxp@s.okayama-u.ac.jp;
   knaruse@md.okayama-u.ac.jp; takah-k2@okayama-u.ac.jp
RI Sokabe, Masahiro/I-1565-2012; Takahashi, Ken/B-1622-2011
OI Liang, Yin/0000-0003-3192-1948; Takahashi, Ken/0000-0002-7580-8691; Liu,
   Yun/0000-0003-0822-2823; MENGXUE, WANG/0000-0002-0756-7427
FU JSPS KAKENHI [17KK0168, 20H04518]; Grants-in-Aid for Scientific Research
   [20H04518, 21H04960, 17KK0168] Funding Source: KAKEN
FX This study was funded by JSPS KAKENHI, Fund for the Promotion of Joint
   International Research (Fostering Joint International Research),
   17KK0168, and JSPS KAKENHI Grant-In-Aid for Scientific Research (B),
   20H04518.
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NR 118
TC 17
Z9 18
U1 5
U2 28
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD APR
PY 2021
VL 22
IS 8
AR 4108
DI 10.3390/ijms22084108
PG 15
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA RT3KD
UT WOS:000644360200001
PM 33921168
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU King, DE
AF King, Dana E.
TI Inflammation and elevation of C-reactive protein: does magnesium play a
   key role?
SO MAGNESIUM RESEARCH
LA English
DT Article
DE magnesium; inflammation; C-reactive protein
ID METABOLIC SYNDROME; DIETARY MAGNESIUM; DIABETES-MELLITUS; DEFICIENCY;
   STRESS
AB The adverse role played by inflammation in the etiology of humankind's most prevalent chronic diseases compels researchers to work diligently to explore its biologic basis. Recent research supports the concept of an important relationship between dietary factors and inflammation, and in particular the role of magnesium deficiency, however, the specifics of this association are not completely understood. Recent findings from epidemiologic studies support that magnesium intake is inversely associated with C-reactive protein concentration, an important marker of inflammation strongly associated with cardiovascular disease risk. Animal studies have provided many mechanistic possibilities to explain the link between magnesium and inflammation. Further research is needed to understand more completely the role of magnesium in inflammation.
C1 Med Univ S Carolina, Dept Family Med, Charleston, SC 29425 USA.
C3 Medical University of South Carolina
RP King, DE (corresponding author), Med Univ S Carolina, Dept Family Med, 295 Calhoun St,MSC 192, Charleston, SC 29425 USA.
EM kingde@musc.edu
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NR 25
TC 38
Z9 39
U1 0
U2 9
PU JOHN LIBBEY EUROTEXT LTD
PI MONTROUGE
PA 127 AVE DE LA REPUBLIQUE, 92120 MONTROUGE, FRANCE
SN 0953-1424
EI 1952-4021
J9 MAGNESIUM RES
JI Magnes. Res.
PD JUN
PY 2009
VL 22
IS 2
BP 57
EP 59
DI 10.1684/mrh.2009.0161
PG 3
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 466OZ
UT WOS:000267673200001
PM 19658273
DA 2025-06-11
ER

PT J
AU Hege, A
   Lemke, MK
   Apostolopoulos, Y
   Sönmez, S
AF Hege, Adam
   Lemke, Michael K.
   Apostolopoulos, Yorghos
   Sonmez, Sevil
TI Occupational health disparities among US long-haul truck drivers: the
   influence of work organization and sleep on cardiovascular and metabolic
   disease risk
SO PLOS ONE
LA English
DT Article
ID SHIFT WORK; PSYCHOSOCIAL FACTORS; NATIONAL-SURVEY; MENTAL-HEALTH;
   STRESS; ENVIRONMENT; ASSOCIATION; PREVALENCE; OBESITY; POPULATION
AB Objective
   The organization of work has undergone vast transformations over the past four decades in the United States and has had profound impacts on worker health and wellbeing. The profession of commercial truck driving is one of the best examples. Particularly for long-haul truck drivers, changes in work organization have led to disproportionately poor physiological, psychological, and sleep health outcomes.
   Methods
   The present study examined disparities in cardiometabolic disease risk among long-haul truck drivers and the general population, and the influence of work organization and sleep in generating these outcomes. Researchers collected survey data from 260 drivers, and blood assay samples from 115 of those drivers, at a large highway truck stop in North Carolina. Comparisons were made for cardiovascular and metabolic risk against the 2011-2012 National Health and Nutrition Examination Survey (NHANES). In addition, logistic regression was used to explore predictive relationships between work organization and sleep and risk for cardiovascular and metabolic disease.
   Results
   There were statistically significant mean differences between the long-haul truck driver sample and the NHANES sample for both cardiovascular (3.71 vs. 3.10; p<0.001) and metabolic (4.31 vs. 3.09; p<0.001) disease risk. The truck driver sample was less physically active and had lower HDL cholesterol along with greater levels of smoking, BMI, and metabolic syndrome diagnosis. More years of driving experience and poor sleep quality were statistically significant predictors for both cardiovascular and metabolic disease risk.
   Conclusions
   Study findings implicate elements of the occupational milieu experienced by long-haul truck drivers that induce disproportionate cardiometabolic disease risk. Sleep quality, largely compromised by poor work conditions and workplace environments, plays a significant role in increased risks for cardiometabolic disease. There is an urgent need for longitudinal studies of this critical occupational sector as well as intervention research centered on policy and systems level change.
C1 [Hege, Adam] Appalachian State Univ, Dept Hlth & Exercise Sci, Boone, NC 28608 USA.
   [Lemke, Michael K.] Univ Houston Downtown, Dept Social Sci, Houston, TX USA.
   [Lemke, Michael K.; Apostolopoulos, Yorghos] Texas A&M Univ, Complex & Computat Populat Hlth Grp, College Stn, TX USA.
   [Apostolopoulos, Yorghos] Texas A&M Univ, Dept Hlth & Kinesiol, College Stn, TX USA.
   [Sonmez, Sevil] Univ Cent Florida, Coll Business Adm, Orlando, FL 32816 USA.
C3 University of North Carolina; Appalachian State University; University
   of Houston System; University of Houston Downtown; University of
   Houston; Texas A&M University System; Texas A&M University College
   Station; Texas A&M University System; Texas A&M University College
   Station; State University System of Florida; University of Central
   Florida
RP Hege, A (corresponding author), Appalachian State Univ, Dept Hlth & Exercise Sci, Boone, NC 28608 USA.
EM hegeba@appstate.edu
RI Hege, Adam/AGF-0054-2022
OI Sonmez, Sevil/0000-0003-1761-2241; Hege, Adam/0000-0003-2515-6848
FU University of North Carolina-Greensboro's Office of Research and
   Economic Development; University of North Carolina-Greensboro's School
   of Health and Human Sciences, Bryan School of Business and Economics,
   Department of Public Health Education; Department of Kinesiology;
   Appalachian State University's Beaver College of Health Sciences;
   University of North Carolina-Greensboro's (UNCG) Office of Research and
   Economic Development; UNCG's School of Health and Human Sciences, Bryan
   School of Business and Economics, Department of Public Health Education
FX Research funds were provided for data collection by the University of
   North Carolina-Greensboro's Office of Research and Economic Development
   to YA. Additional funds were provided by the University of North
   Carolina-Greensboro's School of Health and Human Sciences, Bryan School
   of Business and Economics, Department of Public Health Education, and
   Department of Kinesiology to YA. In addition, funds for manuscript
   development were provided by Appalachian State University's Beaver
   College of Health Sciences to AH. The funders had no role in study
   design, data collection and analysis, decision to publish, or
   preparation of the manuscript. Data collection for this work was
   performed at the University of North Carolina at Greens-boro. This paper
   is part of a commercial driver sleep study conducted with research funds
   awarded by the University of North Carolina-Greensboro's (UNCG) Office
   of Research and Economic Development. Additional funds were provided by
   UNCG's School of Health and Human Sciences, Bryan School of Business and
   Economics, Department of Public Health Education, and Department of
   Kinesiology. In addition, funds provided by the Appalachian State
   University Beaver College of Health Sciences helped to support the
   development of this paper. We would like to thank Mr. Tom Liutkus, Vice
   President of Marketing and Public Relations for Travel Centers of
   America (TA) and Mr. Jerald Brisson, General Manager of the Whitsett, NC
   TA truckstop and his staff for their instrumental support for our
   project and data collection efforts. We also thank the long-haul truck
   drivers who participated in this study.
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NR 116
TC 59
Z9 65
U1 1
U2 14
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD NOV 15
PY 2018
VL 13
IS 11
AR e0207322
DI 10.1371/journal.pone.0207322
PG 18
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Science & Technology - Other Topics
GA HA4SR
UT WOS:000450254000066
PM 30439996
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Tomey, KM
   Chen, DM
   Wang, X
   Braunschweig, CL
AF Tomey, KM
   Chen, DM
   Wang, X
   Braunschweig, CL
TI Dietary intake and nutritional status of urban community-dwelling men
   with paraplegia
SO ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
LA English
DT Article; Proceedings Paper
CT Annual Meeting of the American-College-of-Epidemiology
CY SEP 07-10, 2003
CL Chicago, IL
SP Amer Coll Epidemiol
DE body composition; nutritional status; paraplegia; rehabilitation
ID 3RD NATIONAL-HEALTH; VEGETABLE CONSUMPTION; METABOLIC SYNDROME; FOOD
   FREQUENCY; RISK-FACTORS; US ADULTS; DISEASE; FIBER; QUESTIONNAIRE;
   MORTALITY
AB Objectives: To evaluate nutritional status, dietary intake, nutrition knowledge, and depression of healthy urban men with chronic spinal cord injury (SCI) and to compare these findings with national guidelines and data.
   Design: Cross-sectional.
   Setting: Urban university.
   Participants: Ninety-five community-dwelling men with paraplegia (age range, 20-59y). Interventions: Not applicable. Main Outcome Measures: Dietary intake, body mass index (BMI), waist circumference, knowledge of nutrition, and depression.
   Results: Diets included too much total and saturated fat, and inadequate fiber, calcium, fruit, and dairy intake. Most participants met protein needs, but most calorie levels were at or below recommendations. By using standard BMI and waist circumference cut-points for the able-bodied, approximately half of participants were overweight, 19% were obese, 7.5% were underweight, and more than one third had large waist circumferences. Participants with low knowledge of nutrition and high BMI who lived alone, smoked, and who had low family incomes were at significantly higher risk for lower quality diets. African Americans had the poorest diets.
   Conclusions: Intake of several key nutrients did not meet guidelines, and many BMI and waist circumference values were outside recommended ranges. These data highlight the need for clinicians to screen, counsel, and treat people with SCI to prevent related chronic diseases.
C1 Univ Illinois, Dept Human Nutr MC 517, Chicago, IL 60612 USA.
   Rehabil Inst Chicago, Chicago, IL 60611 USA.
   Kraft Gen Foods Inc, Glenview, IL 60025 USA.
C3 University of Illinois System; University of Illinois Chicago;
   University of Illinois Chicago Hospital; Shirley Ryan AbilityLab; Kraft
   Heinz
RP Univ Illinois, Dept Human Nutr MC 517, 1919 W Taylor St,Rm 650, Chicago, IL 60612 USA.
EM ktomey@uic.edu
OI August, Carmella/0000-0001-5151-1036
FU AHRQ HHS [R03 HS 11277-01] Funding Source: Medline
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NR 57
TC 67
Z9 76
U1 0
U2 7
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0003-9993
EI 1532-821X
J9 ARCH PHYS MED REHAB
JI Arch. Phys. Med. Rehabil.
PD APR
PY 2005
VL 86
IS 4
BP 664
EP 671
DI 10.1016/j.apmr.2004.10.023
PG 8
WC Rehabilitation; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Rehabilitation; Sport Sciences
GA 914ON
UT WOS:000228237300008
PM 15827915
DA 2025-06-11
ER

PT J
AU Bar-Tana, J
AF Bar-Tana, Jacob
TI TorS - Reframing a rational for type 2 diabetes treatment
SO DIABETES-METABOLISM RESEARCH AND REVIEWS
LA English
DT Review
DE insulin; metabolic stress; metabolic syndrome (MetS); mTORC1syndrome
   (TorS); type 2 diabetes (T2D)
ID MUSCLE-CELL PROLIFERATION; ACTIVATED PROTEIN-KINASE; GLP-1 RECEPTOR
   AGONISTS; PPAR-GAMMA; INSULIN-RESISTANCE; COMPLEX-I; MAMMALIAN TARGET;
   KIDNEY-DISEASE; METFORMIN; AMPK
AB The mammalian target of rapamycin complex 1 syndrome (Tors), paradigm implies an exhaustive cohesive disease entity driven by a hyperactive mTORC1, and which includes obesity, type 2 diabetic hyperglycemia, diabetic dyslipidemia, diabetic cardiomyopathy, diabetic nephropathy, diabetic peripheral neuropathy, hypertension, atherosclerotic cardiovascular disease, non-alcoholic fatty liver disease, some cancers, neurodegeneration, polycystic ovary syndrome, psoriasis and other. The TorS paradigm may account for the efficacy of standard-of-care treatments of type 2 diabetes (T2D) in alleviating the glycaemic and non-glycaemic diseases of TorS in T2D and non-T2D patients. The TorS paradigm may generate novel treatments for TorS diseases.
C1 [Bar-Tana, Jacob] Hebrew Univ Jerusalem, Med Sch, Jerusalem, Israel.
C3 Hebrew University of Jerusalem
RP Bar-Tana, J (corresponding author), Hebrew Univ Jerusalem, Med Sch, Jerusalem, Israel.
EM jacobb@ekmd.huji.ac.il
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NR 164
TC 1
Z9 1
U1 0
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1520-7552
EI 1520-7560
J9 DIABETES-METAB RES
JI Diabetes-Metab. Res. Rev.
PD JAN
PY 2024
VL 40
IS 1
AR e3712
DI 10.1002/dmrr.3712
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA FS8W6
UT WOS:001147946300001
PM 37615286
OA hybrid
DA 2025-06-11
ER

PT J
AU Sosedova, LM
   Yakimova, NL
   Vokina, VA
AF Sosedova, L. M.
   Yakimova, N. L.
   Vokina, V. A.
TI The Effect of Confounding Factors in Biomodeling of Intoxication
SO BIOLOGY BULLETIN
LA English
DT Article
ID METABOLIC SYNDROME; FETAL
AB The results of modeling intoxication in rats using lead acetate against the background of metabolic changes in the body and prenatal stress are presented. The motor activity and cognitive abilities, serum total cholesterol and lipid fractions, and bioelectric activity of the brain have been identified by testing the animals. It was found that intoxication with lead acetate against hyperglycemia or hyperlipidemia compared with the individual effects of lead acetate resulted in impaired cognitive abilities of animals and pronounced atherogenic changes, which included an increase in the concentrations of low-density lipoprotein cholesterol, triglycerides, and an atherogenic coefficient. It was recorded that lead intoxication complicated by metabolic disorders caused more prominent pathological changes in ECG parameters, such as tachycardia and a change in the duration of intraventricular conduction.
C1 [Sosedova, L. M.; Yakimova, N. L.; Vokina, V. A.] East Siberian Inst Med & Ecol Res, Angarsk 665827, Russia.
RP Sosedova, LM (corresponding author), East Siberian Inst Med & Ecol Res, Angarsk 665827, Russia.
EM sosedlar@mail.ru
RI Sosedova, Larisa/J-4577-2018; Iakimova, Natalya/J-4517-2018; Vokina,
   Vera/Q-7216-2016
OI Iakimova, Natalya/0000-0002-9686-3841; Vokina, Vera/0000-0002-8165-8052
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PU PLEIADES PUBLISHING INC
PI MOSCOW
PA PLEIADES PUBLISHING INC, MOSCOW, 00000, RUSSIA
SN 1062-3590
EI 1608-3059
J9 BIOL BULL+
JI Biol. Bull
PD NOV
PY 2019
VL 46
IS 6
BP 608
EP 614
DI 10.1134/S1062359019040149
PG 7
WC Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics
GA KI4QE
UT WOS:000511334100017
DA 2025-06-11
ER

PT J
AU Chen, H
AF Chen, Hong
TI Cellular inflammatory responses: Novel insights for obesity and insulin
   resistance
SO PHARMACOLOGICAL RESEARCH
LA English
DT Review
DE insulin resistance; obesity; diabetes; cellular inflammatory response;
   chronic inflammation
ID NECROSIS-FACTOR-ALPHA; C-REACTIVE PROTEIN; ENDOPLASMIC-RETICULUM STRESS;
   ACUTE-PHASE PROTEINS; MONOCYTE CHEMOATTRACTANT PROTEIN-1; TYPE-2
   DIABETES-MELLITUS; ADIPOSE-TISSUE; WEIGHT-LOSS; TNF-ALPHA; METABOLIC
   SYNDROME
AB Type 2 diabetes is rapidly becoming a worldwide epidemic. Obesity and sedentary lifestyle are the main environmental causes for the development of insulin resistance and type 2 diabetes. In the past decade, it has been increasingly recognized that obesity and insulin resistance are associated with chronic, low-grade systemic inflammation. This review will cover the recent advances in this field and provide a working model explaining how cellular inflammatory responses arise to cope with obesity-induced metabolic stresses and how these inflammatory responses underlie insulin resistance. (c) 2006 Elsevier Ltd. All rights reserved.
C1 Novartis Inst Biomed Res Inc, Cambridge, MA 02139 USA.
C3 Novartis; Novartis USA
RP Chen, H (corresponding author), Novartis Inst Biomed Res Inc, 100 Technol Sq, Cambridge, MA 02139 USA.
EM hong.chen@novartis.com
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NR 135
TC 47
Z9 60
U1 1
U2 11
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 1043-6618
J9 PHARMACOL RES
JI Pharmacol. Res.
PD JUN
PY 2006
VL 53
IS 6
BP 469
EP 477
DI 10.1016/j.phrs.2006.03.003
PG 9
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 055NN
UT WOS:000238457500004
PM 16632376
DA 2025-06-11
ER

PT J
AU Basterra-Gortari, V
   Sayón-Orea, C
   Martinez-Gonzalez, MA
   Bes-Rastrollo, M
AF Basterra-Gortari, Virginia
   Sayon-Orea, Carmen
   Martinez-Gonzalez, Miguel A.
   Bes-Rastrollo, Maira
TI Influence of Psychological Well-Being on Health: Systematic Review and
   Meta-Analysis of Hypertension, Overweight/Obesity, and Mortality,
   Including Suicide
SO HEALTH PSYCHOLOGY
LA English
DT Article; Early Access
DE psychological well-being; mortality; suicide; hypertension;
   obesity/overweight
ID POSITIVE MENTAL-HEALTH; LIFE SATISFACTION; STRESS; SENSE
AB Objectives: Psychological well-being (PWB) has demonstrated health-protective effects, but its impact on specific causes of death and cardiovascular risk factors incidence has received limited attention. This systematic review and meta-analysis (PROSPERO Registration: CRD42023387665) examine any positive dimension of PWB's association with the incidence of hypertension, overweight/obesity, metabolic syndrome, deaths from suicide, and noncommunicable disease mortality in the general adult population. Method: PubMed and PsycINFO were searched up to June 3, 2023. Random-effects meta-analyses estimated different outcome effect sizes. Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines were followed. Heterogeneity was assessed using the I2 statistic, studies quality with the Newcastle-Ottawa scale, publication bias through funnel plots, and Egger's test. Subgroup (PWB dimensions, sex, quality assessment, sample size, follow-up period, and publication dates) and metaregression analyses were conducted. Results: The search identified 6,200 studies, with 159 articles eligible for review and 130 for meta-analysis. Higher PWB was associated with lower all-cause mortality (OR = 0.798, 95% confidence interval [CI] [0.773, 0.823], I-2 = 88.03%), and mortality from causes like suicide (OR = 0.505, 95% CI [0.337, 0.756], I-2 = 0.0%), cancer (OR = 0.924, 95% CI [0.858, 0.995], I-2 = 35.42%), cardiovascular disease (OR = 0.769, 95% CI [0.712, 0.832], I-2 = 55.64%), stroke (OR = 0.726, 95% CI [0.615, 0.858], I-2 = 56.96%), coronary heart disease (OR = 0.823, 95% CI [0.735, 0.922], I-2 = 45.03%), and hypertension incidence (OR = 0.921, 95% CI [0.860, 0.987], I-2 = 68.91%). No significant association was found for overweight/obesity incidence (OR = 0.922, 95% CI [0.801, 1.061], I-2 = 0.0%). Common sources of heterogeneity could not be identified. Conclusion: Higher PWB was associated with lower noncommunicable disease mortality, likely including suicide, and lower hypertension incidence. The limited number of studies on some outcomes, along with potential publication bias and heterogeneity, constrain definitive conclusions.
C1 [Basterra-Gortari, Virginia] Univ Navarra, Dept Prevent Med & Publ Hlth, Pamplona, Spain.
   [Basterra-Gortari, Virginia] Navarra Healthcare Syst, Mental Hlth Dept, Pamplona, Spain.
   [Sayon-Orea, Carmen; Martinez-Gonzalez, Miguel A.; Bes-Rastrollo, Maira] Univ Navarra, Navarra Inst Hlth Res, Dept Prevent Med & Publ Hlth, IdiSNA, Pamplona, Spain.
   [Martinez-Gonzalez, Miguel A.] Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA.
C3 University of Navarra; University of Navarra; Harvard University;
   Harvard T.H. Chan School of Public Health
RP Sayón-Orea, C (corresponding author), Univ Navarra, Navarra Inst Hlth Res, Dept Prevent Med & Publ Hlth, IdiSNA, Edificio Invest,2 Planta,Local 2520, Pamplona 31008, Navarra, Spain.
EM msayon@unav.es
RI basterra, virginia/HSG-3833-2023; Bes-Rastrollo, Maira/A-1329-2009;
   Sayón-Orea, Carmen/A-9828-2017
FU Spanish Government-Instituto de Salud Carlos III; European Regional
   Development Fund (FEDER); European Union [PI20/00564, PI23/01332]
FX This work was supported by the Spanish Government-Instituto de Salud
   Carlos III and the European Regional Development Fund (FEDER), cofunded
   by the European Union (PI20/00564, PI23/01332). None of the authors have
   any proprietary interests or conflicts of interest related to this
   submission. Data will be available upon reasonable request from the
   corresponding author.
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   Zalsman Gil, 2019, Harefuah, V158, P468
NR 42
TC 0
Z9 0
U1 4
U2 4
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 0278-6133
EI 1930-7810
J9 HEALTH PSYCHOL
JI Health Psychol.
PD 2025 MAR 31
PY 2025
DI 10.1037/hea0001475
EA MAR 2025
PG 12
WC Psychology, Clinical; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology
GA 0TJ9K
UT WOS:001455572800001
PM 40167558
DA 2025-06-11
ER

PT J
AU Zhang, L
   Shang, FJ
   Liu, C
   Zhai, XD
AF Zhang, Le
   Shang, Fangjian
   Liu, Cong
   Zhai, Xiaodan
TI The correlation between iodine and metabolism: a review
SO FRONTIERS IN NUTRITION
LA English
DT Review
DE iodine; metabolism; obesity; dyslipidemia; antioxidant
ID OXIDATIVE STRESS; URINARY IODINE; ANTIOXIDANT; SEAWEED; EXCESS; WOMEN;
   DIFFERENTIATION; ASSOCIATION; PREVALENCE; DEIODINASE
AB Iodine is involved in the synthesis of thyroid hormones and plays a crucial role in human life. Both iodine deficiency and excess are common issues in certain populations. Iodine also has extrathyroidal effects on organs that can uptake it independently of thyroid hormones. Recently, multiple clinical studies have shown a connection between iodine intake and metabolic disorders, such as metabolic syndrome, obesity, diabetes, hypertension, and dyslipidemia. However, the results of these studies have been inconsistent, and the mechanisms behind these associations are still not well understood. Therefore, in this review, we aim to examine the recent research progress regarding the relationship between iodine and metabolic disorders, along with the relevant mechanisms.
C1 [Zhang, Le; Liu, Cong; Zhai, Xiaodan] China Med Univ, Shengjing Hosp, Dept Endocrinol, Shenyang, Peoples R China.
   [Shang, Fangjian] China Med Univ, Dept Gen Surg, Affiliated Hosp 4, Shenyang, Peoples R China.
C3 China Medical University; China Medical University
RP Zhai, XD (corresponding author), China Med Univ, Shengjing Hosp, Dept Endocrinol, Shenyang, Peoples R China.
EM zhaixiaodan0712@126.com
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NR 74
TC 6
Z9 6
U1 4
U2 9
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD MAR 19
PY 2024
VL 11
AR 1346452
DI 10.3389/fnut.2024.1346452
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA MO9C6
UT WOS:001194670500001
PM 38567251
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Zhang, BB
   Zhou, GC
   Li, C
AF Zhang, Bei B.
   Zhou, Gaochao
   Li, Cai
TI AMPK: An Emerging Drug Target for Diabetes and the Metabolic Syndrome
SO CELL METABOLISM
LA English
DT Review
ID ACTIVATED-PROTEIN-KINASE; FATTY-ACID OXIDATION; IMPROVES
   GLUCOSE-METABOLISM; HUMAN SKELETAL-MUSCLE; INSULIN-RESISTANCE;
   LIPID-METABOLISM; GENE-EXPRESSION; FOOD-INTAKE; FED RATS; MECHANISM
AB Adenosine 5'-monophosphate (AMP)-activated protein kinase (AMPK) is a key player in regulating energy metabolism, placing it at the center stage in studies of diabetes and related metabolic diseases. Expressed in key metabolically relevant organs, AMPK is activated in response to a variety of stimuli, including cellular stress, exercise, and a wide range of hormones and agents that exert impacts on cellular metabolism. Genetic and pharmacological studies demonstrate that AMPK is required for maintaining glucose homeostasis. Activation of AMPK by pharmacological agents presents a unique challenge, given the complexity of the biology, but holds a considerable potential to reverse the metabolic abnormalities associated with type 2 diabetes.
C1 [Zhang, Bei B.; Zhou, Gaochao; Li, Cai] Merck Res Labs, Dept Metab Disorders, Rahway, NJ 07065 USA.
C3 Merck & Company
RP Zhang, BB (corresponding author), Merck Res Labs, Dept Metab Disorders, Rahway, NJ 07065 USA.
EM bei_zhang@merck.com
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NR 82
TC 903
Z9 1011
U1 2
U2 176
PU CELL PRESS
PI CAMBRIDGE
PA 50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA
SN 1550-4131
EI 1932-7420
J9 CELL METAB
JI Cell Metab.
PD MAY 6
PY 2009
VL 9
IS 5
BP 407
EP 416
DI 10.1016/j.cmet.2009.03.012
PG 10
WC Cell Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Endocrinology & Metabolism
GA 442LC
UT WOS:000265841700005
PM 19416711
OA Bronze
DA 2025-06-11
ER

PT J
AU Beaton, MD
   Adams, PC
AF Beaton, Melanie D.
   Adams, Paul C.
TI Treatment of hyperferritinemia
SO ANNALS OF HEPATOLOGY
LA English
DT Review
DE Iron overload; Ferritin; Liver Disease; Therapy
ID FATTY LIVER-DISEASE; BODY IRON STORES; SERUM FERRITIN;
   HEPATOCELLULAR-CARCINOMA; METABOLIC SYNDROME; TRANSFERRIN SATURATION;
   OXIDATIVE STRESS; HEMOCHROMATOSIS; OVERLOAD; RISK
AB Elevated serum ferritin, or hyperferritinemia, is a common finding on routine bloodwork and often prompts referral for further evaluation. In the following review, we outline the various causes of hyperferritinemia and point out that, in the majority of cases, this does not represent true iron overload. Despite much research interest in this area, the precise mechanism of hyperferritinemia and its impact on disease severity in various clinical conditions continues to be debated. While some research suggests that iron reduction in cases of hyperferritinemia is of benefit, the decision to treat such patients should be individualized, and may be influenced by the presence of other features of iron overload.
C1 [Beaton, Melanie D.; Adams, Paul C.] Univ Western Ontario, London Hlth Sci Ctr, Dept Med, Div Gastroenterol, London, ON N6A 5A5, Canada.
C3 Western University (University of Western Ontario); London Health
   Sciences Centre
RP Adams, PC (corresponding author), Univ Western Ontario, Univ Hosp, 339 Windermere Rd, London, ON N6A 5A5, Canada.
EM padams@uwo.ca
RI Beaton, Melanie/G-3278-2011; Adams, Paul/G-2868-2011
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NR 40
TC 34
Z9 36
U1 0
U2 8
PU ELSEVIER ESPANA
PI MADRID
PA CALLE DE ZURBANO, 76-4TH FLR LEFT, MADRID, 28010, SPAIN
SN 1665-2681
J9 ANN HEPATOL
JI Ann. Hepatol.
PD MAY-JUN
PY 2012
VL 11
IS 3
BP 294
EP 300
DI 10.1016/S1665-2681(19)30923-8
PG 7
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 010NE
UT WOS:000309100300002
PM 22481446
OA hybrid
DA 2025-06-11
ER

PT J
AU Aleali, AM
   Amani, R
   Shahbazian, H
   Namjooyan, F
   Latifi, SM
   Cheraghian, B
AF Aleali, Armaghan Moravej
   Amani, Reza
   Shahbazian, Hajieh
   Namjooyan, Frough
   Latifi, Seyed Mahmoud
   Cheraghian, Bahman
TI The effect of hydroalcoholic Saffron (Crocus sativus L.)
   extract on fasting plasma glucose, HbA1c, lipid profile, liver, and
   renal function tests in patients with type 2 diabetes mellitus: A
   randomized double-blind clinical trial
SO PHYTOTHERAPY RESEARCH
LA English
DT Article
DE fasting plasma glucose; HbA(1)c; lipid profile; saffron; type 2 diabetes
ID TO-MODERATE DEPRESSION; OXIDATIVE STRESS; ISCHEMIA-REPERFUSION;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; ETHANOLIC EXTRACT; BLOOD-GLUCOSE
AB Diabetes mellitus is a metabolic disease that manifested as hyperglycemia due to the defect in secretion or function of insulin. Studies have shown that saffron and its derivatives cause a significant reduction in plasma glucose levels in experimental models. The purpose of this study was to investigate the effect of the saffron extract on fasting plasma glucose (FPG), glycated hemoglobin level (HbA1c), lipid profile, liver enzymes, and renal function tests in type 2 diabetic patients. In this double-blind randomized clinical trial, 64 type 2 diabetic patients who were on oral anti-diabetic drugs were examined. Participants received either 15 mg of saffron or placebo capsules (two pills per day) for 3 months. Anthropometric indices, dietary intake, FPG, HbA1c, lipid profiles, liver enzymes (ALT, AST, ALP), and renal function (BUN, Cr.) tests were measured pre and post intervention after 3 months. Independent t test and paired t test were used for data analysis. After 3-months intervention, mean difference of FPG, Cholesterol, LDL-c, and LDL/HDL ratio between two groups showed significant reduction(p < 0.0001), but HbA1c, HDL-C, API, TG showed no significant differences (p > 0.05). In saffron group, FPG, HbA1c, cholesterol, LDL-c, and LDL/HDL ratio decreased significantly after 3-months intervention compare with baseline (p < 0.0001).
C1 [Aleali, Armaghan Moravej; Amani, Reza; Shahbazian, Hajieh; Latifi, Seyed Mahmoud] Ahvaz Jundishapur Univ Med Sci, Hlth Res Inst, Diabet Res Ctr, Ahvaz, Iran.
   [Amani, Reza] Isfahan Univ Med Sci, Sch Nutr & Food Sci, Dept Clin Nutr, Food Secur Res Ctr, Esfahan, Iran.
   [Namjooyan, Frough] Ahvaz Jundishapur Univ Med Sci, Dept Pharmacognosy, Marine Pharmaceut Res Ctr, Fac Pharm, Ahvaz, Iran.
   [Latifi, Seyed Mahmoud; Cheraghian, Bahman] Ahvaz Jundishapur Univ Med Sci, Sch Publ Hlth, Dept Epidemiol & Biostat, Ahvaz, Iran.
C3 Ahvaz Jundishapur University of Medical Sciences (AJUMS); Isfahan
   University of Medical Sciences; Ahvaz Jundishapur University of Medical
   Sciences (AJUMS); Ahvaz Jundishapur University of Medical Sciences
   (AJUMS)
RP Amani, R (corresponding author), Isfahan Univ Med Sci, Sch Nutr & Food Sci, Dept Clin Nutr, Food Secur Res Ctr, Esfahan, Iran.
EM r_amani@nutr.mui.ac.ir
RI Latifi, seyed/ABB-2893-2020; Namjoyan, Foroogh/ABC-6615-2021;
   cheraghian, bahman/L-8808-2017; shahbazian, hajie/ABB-2262-2020; Amani,
   Reza/U-7483-2017
OI Moravej Aleali, Armaghan/0000-0002-0694-0656; Amani,
   Reza/0000-0002-0074-4080; Cheraghian, Bahman/0000-0001-5446-6998;
   Namjoyan, Foroogh/0000-0002-3171-479X; Latifi, Seyed
   Mahmoud/0000-0001-8989-5397; shahbazian, Hajieh/0000-0002-9265-4022
FU Ahvaz Jundishapur University of Medical Sciences [D-9407]
FX This study was part of PhD thesis of Armaghan Moravej Aleali (D-9407)
   registered in Diabetes Research Center, Health Research Institute.
   Financial support was provided by Vice-Chancellor for Research, Ahvaz
   Jundishapur University of Medical Sciences.
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NR 44
TC 67
Z9 68
U1 0
U2 34
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0951-418X
EI 1099-1573
J9 PHYTOTHER RES
JI Phytother. Res.
PD JUN
PY 2019
VL 33
IS 6
BP 1648
EP 1657
DI 10.1002/ptr.6351
PG 10
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA ID7ZJ
UT WOS:000471901200006
PM 30942510
DA 2025-06-11
ER

PT J
AU Ziaei, S
   Naved, RT
   Rahman, A
   Raqib, R
   Ekström, EC
AF Ziaei, Shirin
   Naved, Ruchira Tabassum
   Rahman, Anisur
   Raqib, Rubhana
   Ekstrom, Eva-Charlotte
TI Maternal Experience of Domestic Violence, Associations with Children's
   Lipid Biomarkers at 10 Years: Findings from MINIMat Study in Rural
   Bangladesh
SO NUTRIENTS
LA English
DT Article
DE domestic violence; children; lipid biomarkers; Bangladesh
ID CARDIOVASCULAR RISK-FACTORS; INTIMATE PARTNER VIOLENCE; METABOLIC
   SYNDROME; YOUNG ADULTHOOD; SEXUAL VIOLENCE; MENTAL-HEALTH; STRESS;
   CHILDHOOD; WOMEN; CONSEQUENCES
AB The consequences of maternal experience of Domestic Violence (DV) on their children's cardio-metabolic risk factors are unclear. We aimed to assess if maternal exposure to any or a specific form of DV (i.e., physical, sexual, emotional and controlling behaviors) before and after childbirth was associated with their children's lipid biomarkers at the age of 10 years. A current observational sub-study of a larger MINIMat trial included a cohort of 1167 mothers and their children. The conflict tactic scale was used to record women's experience of lifetime DV before and after childbirth at week 30 of pregnancy and at a 10-year follow up, respectively. Five ml of fasting blood sample was collected from the children to evaluate their lipid profile. Children of women who experienced any DV before childbirth had lower Apo A ((adj) -0.04; 95% CI: -0.08, -0.01). Women who experienced physical DV both before and after childbirth had children with higher triglycerides ((adj) 0.07; 95% CI: 0.01, 0.14). Children whose mother experienced sexual DV before birth had lower Apo A ((adj) -0.05; 95% CI: -0.08, -0.01) and High Density Lipoprotein (HDL) ((adj) -0.05; 95% CI: -0.10, -0.01) as well as higher Low Density Lipoprotein (LDL) ((adj) 0.17; 95% CI: 0.05, 0.29) and LDL/HDL ( 0.24; 95% CI: 0.11, 0.38). However, levels of LDL ((adj) -0.17; 95% CI: -0.28, -0.06), LDL/HDL ((adj) -0.12; 95% CI: -0.25, -0.00) and cholesterol ((adj) -0.13; 95% CI: -0.25, -0.02) were lower among the children of mothers who experienced controlling behavior after childbirth. Results from the current study suggest that maternal experience of physical or sexual DV might negatively affect their children's lipid profile at the age of 10 years.
C1 [Ziaei, Shirin; Ekstrom, Eva-Charlotte] Uppsala Univ, Dept Womens & Childrens Hlth, SE-75185 Uppsala, Sweden.
   [Naved, Ruchira Tabassum; Rahman, Anisur; Raqib, Rubhana] ICDDR B, Dhaka 1212, Bangladesh.
C3 Uppsala University; International Centre for Diarrhoeal Disease Research
   (ICDDR)
RP Ziaei, S (corresponding author), Uppsala Univ, Dept Womens & Childrens Hlth, SE-75185 Uppsala, Sweden.
EM shirin.ziaei@kbh.uu.se; ruchira@icddrb.org; arahman@icddrb.org;
   rubhana@icddrb.org; Lotta.Ekstrom@kbh.uu.se
RI Rahman, Anisur/L-8316-2019; zaiei, shirin/ABC-3245-2021
OI ziaei, shirin/0000-0001-5396-6624; Naved, Ruchira/0000-0002-0363-5648;
   Ekstrom, Eva-Charlotte/0000-0001-5464-7756; Rahman,
   Anisur/0000-0003-1033-5034
FU Swedish Research Council [521-2011-3124]
FX This research was funded by Swedish Research Council, grant number
   #521-2011-3124.
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NR 56
TC 3
Z9 3
U1 0
U2 1
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD APR
PY 2019
VL 11
IS 4
AR 910
DI 10.3390/nu11040910
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nutrition & Dietetics
GA HX9SX
UT WOS:000467749800203
PM 31018615
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Massalha, M
   Iskander, R
   Hassan, H
   Spiegel, E
   Erez, O
   Nachum, Z
AF Massalha, Manal
   Iskander, Rula
   Hassan, Haya
   Spiegel, Etty
   Erez, Offer
   Nachum, Zohar
TI Gestational diabetes mellitus - more than the eye can see - a warning
   sign for future maternal health with transgenerational impact
SO FRONTIERS IN CLINICAL DIABETES AND HEALTHCARE
LA English
DT Review
DE metabolic syndrome; insulin; preeclampsia; pregnancy complications;
   lipid profile; macrosomia
ID FETAL WEIGHT ESTIMATION; GLUCOSE-TOLERANCE TEST; BETA-CELL FUNCTION;
   BODY-MASS INDEX; INSULIN-RESISTANCE; RISK-FACTORS; PREGNANT-WOMEN;
   PLACENTAL GH; INTERNATIONAL ASSOCIATION; OXIDATIVE STRESS
AB Gestational diabetes mellitus (GDM) is regarded by many as maternal maladaptation to physiological insulin resistance during the second half of pregnancy. However, recent evidence indicates that alterations in carbohydrate metabolism can already be detected in early pregnancy. This observation, the increasing prevalence of GDM, and the significant short and long-term implications for the mother and offspring call for reevaluation of the conceptual paradigm of GDM as a syndrome. This review will present evidence for the syndromic nature of GDM and the controversies regarding screening, diagnosis, management, and treatment.
C1 [Massalha, Manal; Iskander, Rula; Hassan, Haya; Spiegel, Etty; Nachum, Zohar] Emek Med Ctr, Dept Obstet & Gynecol, Afula, Israel.
   [Massalha, Manal; Nachum, Zohar] Technion Israel Inst Technol, Rappaport Fac Med, Haifa, Israel.
   [Erez, Offer] Soroka Univ, Dept Obstet & Gynecol, Med Ctr, Beer Sheva, Israel.
   [Erez, Offer] Ben Gurion Univ Negev, Fac Med, Beer Sheva, Israel.
   [Erez, Offer] Wayne State Univ, Hutzel Womens Hosp, Dept Obstet & Gynecol, Detroit, MI 48202 USA.
C3 Emek Medical Center; Technion Israel Institute of Technology; Rappaport
   Faculty of Medicine; Ben-Gurion University of the Negev; Soroka Medical
   Center; Ben-Gurion University of the Negev; Wayne State University
RP Nachum, Z (corresponding author), Emek Med Ctr, Dept Obstet & Gynecol, Afula, Israel.; Nachum, Z (corresponding author), Technion Israel Inst Technol, Rappaport Fac Med, Haifa, Israel.; Erez, O (corresponding author), Soroka Univ, Dept Obstet & Gynecol, Med Ctr, Beer Sheva, Israel.; Erez, O (corresponding author), Ben Gurion Univ Negev, Fac Med, Beer Sheva, Israel.; Erez, O (corresponding author), Wayne State Univ, Hutzel Womens Hosp, Dept Obstet & Gynecol, Detroit, MI 48202 USA.
EM offere@clalit.org.il; nachum.zo@gmail.com
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NR 242
TC 0
Z9 0
U1 0
U2 0
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 2673-6616
J9 FRONT CLIN DIABETES
JI Front. Clin. Diabet. Healthc.
PD APR 1
PY 2025
VL 6
AR 1527076
DI 10.3389/fcdhc.2025.1527076
PG 19
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA 1JN8C
UT WOS:001466533000001
PM 40235646
OA gold
DA 2025-06-11
ER

PT J
AU Noureddin, M
   Rinella, ME
AF Noureddin, Mazen
   Rinella, Mary E.
TI Nonalcoholic Fatty Liver Disease, Diabetes, Obesity, and Hepatocellular
   Carcinoma
SO CLINICS IN LIVER DISEASE
LA English
DT Article
DE Nonalcoholic steatohepatitis; Cirrhosis; Noncirrhotic; Insulin
   resistance; Hepatocellular carcinoma; Obesity; Diabetes; Chemoprevention
ID ENDOPLASMIC-RETICULUM STRESS; UNFOLDED PROTEIN RESPONSE; TERM-FOLLOW-UP;
   S-ADENOSYLMETHIONINE; RISK-FACTORS; METABOLIC SYNDROME; NATURAL-HISTORY;
   CANCER-RISK; HEPATITIS-C; KAPPA-B
AB Diabetes and obesity are associated with nonalcoholic fatty liver disease (NAFLD) and an increased incidence of hepatocellular carcinoma (HOC). NAFLD is the commonest cause of chronic liver disease. HOC can develop in NAFLD patients even without cirrhosis, suggesting an association between the metabolic process and HOC and raising a concern that many cancers could be missed given high NAFLD prevalence and screening limitations. The increasing prevalence of these conditions and lack of effective treatments necessitate a better understanding of their connection. This article defines the known interrelationships and common pathways between NAFLD, diabetes, obesity and HOC and possible chemoprevention strategies.
C1 [Noureddin, Mazen] Univ So Calif, Keck Sch Med, Div Gastrointestinal & Liver Dis, Los Angeles, CA 90033 USA.
   [Rinella, Mary E.] Northwestern Univ, Feinberg Sch Med, Div Gastroenterol & Hepatol, Chicago, IL 60611 USA.
C3 University of Southern California; Northwestern University; Feinberg
   School of Medicine
RP Rinella, ME (corresponding author), Northwestern Univ, Feinberg Sch Med, Div Gastroenterol & Hepatol, 676 North St Clair,Arkes Pavill 14-005, Chicago, IL 60611 USA.
EM m-rinella@northwestern.edu
RI rinella, mary/AAJ-4065-2021
FU USC Research Center of Liver Diseases [P30 DK48522]
FX USC Research Center of Liver Diseases, P30 DK48522. Dr M.E. Rinella has
   provided consulting services for Abbvie, Fibrogen, Takeda, and NGM
   pharmaceuticals. Dr M. Noureddin has nothing to disclose.
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NR 117
TC 143
Z9 150
U1 2
U2 20
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 1089-3261
EI 1557-8224
J9 CLIN LIVER DIS
JI Clin. Liver Dis.
PD MAY
PY 2015
VL 19
IS 2
BP 361
EP +
DI 10.1016/j.cld.2015.01.012
PG 20
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA CI3RG
UT WOS:000354664500010
PM 25921668
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Samavat, S
   Ahmadpoor, P
AF Samavat, Shiva
   Ahmadpoor, Pedram
TI Aldosterone, Hypertension, and Beyond
SO IRANIAN JOURNAL OF KIDNEY DISEASES
LA English
DT Review
DE aldosterone; hypertension; epithelial sodium channel;
   serum-glucocorticoid regulated kinase
ID KINASE SGK1; GENE; FIBROSIS; ASSOCIATION; PREVALENCE; MECHANISMS;
   EXPRESSION; SALT; ENAC
AB Aldosterone, a mineralocorticoid hormone, has a well-known function on water balance and blood pressure homeostasis. Recently, its role in metabolic syndrome, insulin resistance, and obesity has come into a spotlight. Aldosterone induces inflammation and oxidative stress that are attenuated by mineralocorticoid receptor blockers such as spironolactone. Aldosterone exerts its effects via the epithelial sodium channel by non-genomic pathways, including serum and glucocorticoid kinase 1, neural precursor cell-expressed developmentally downregulated (gene 4) protein, and K-Ras, and genomic pathways via epigenetic mechanisms. Beyond regulating epithelial sodium channel, aldosterone induces cardiac hypertrophy, endothelial dysfunction, podocyte injury, and fibrosis. This opens new horizons for mineralocorticoid receptor antagonists and novel therapeutic targets such as serum-glucocorticoid regulated kinase 1.
C1 [Samavat, Shiva; Ahmadpoor, Pedram] Shahid Beheshti Univ Med Sci, Shaheed Labbafinejad Med Ctr, Dept Nephrol, Tehran, Iran.
C3 Shahid Beheshti University Medical Sciences
RP Ahmadpoor, P (corresponding author), Shahid Labbafinejad Med Ctr, Dept Internal Med, 9th Boustan St,Pasdaran Ave, Tehran, Iran.
EM pedram.ahmadpoor@gmail.com
RI Samavat, Shiva/AAU-4894-2021; Ahmadpour, Pedram/O-9060-2019
OI Samavat, Shiva/0000-0001-6707-7844
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NR 34
TC 10
Z9 13
U1 0
U2 2
PU IRANIAN SOC NEPHROLGY
PI TEHRAN
PA APT 12, NO 63, SHAHEED TOUSI ST, DR GHARIB ST, KESHAVARZ BLVD, TEHRAN,
   1419783311, IRAN
SN 1735-8582
EI 1735-8604
J9 IRAN J KIDNEY DIS
JI Iran. J. Kidney Dis.
PD MAR
PY 2011
VL 5
IS 2
BP 71
EP 76
PG 6
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 849MJ
UT WOS:000297129300001
PM 21368382
DA 2025-06-11
ER

PT J
AU Hansraj, KK
   Hansraj, JA
   Rozic, U
   Hansraj, MDG
   Choudhary, D
AF Hansraj, Kenneth K.
   Hansraj, Jonathan A.
   Rozic, Uros
   Hansraj, Marcia D. Griffin
   Choudhary, Deepak
TI Belly Fat Forces on the Spine: Finite Element Analysis of Belly Fat
   Forces by Waist Circumference
SO SURGICAL TECHNOLOGY INTERNATIONAL-INTERNATIONAL DEVELOPMENTS IN SURGERY
   AND SURGICAL RESEARCH
LA English
DT Article
ID ADIPOSE-TISSUE; MODELS
AB Object: It has been well-established that obesity, or the fat content of the belly, is associated with diabetes, heart conditions, metabolic syndrome and back pain. With regard to back pain, this study aimed to assess the forces that incremental amounts of belly fat exert on the spine.
   Methods: A finite element analysis (FEA) was performed with a 3D CAD model of the spine using data for various populations from the Dallas Heart Study.
   Results: There were significant differences in the forces exerted on the spine by belly fat among ethnic groups.
   Conclusions: These findings should help clarify the stress forces experienced by the spine in relation to waist circumference and could help to explain the association between obesity and back pain.
C1 [Hansraj, Kenneth K.; Hansraj, Jonathan A.; Rozic, Uros; Hansraj, Marcia D. Griffin; Choudhary, Deepak] New York Spine Surg & Rehabil Med, Poughkeepsie, NY 12601 USA.
RP Hansraj, KK (corresponding author), New York Spine Surg & Rehabil Med, Poughkeepsie, NY 12601 USA.
RI Choudhary, Deepak/AAQ-5150-2021
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NR 25
TC 0
Z9 0
U1 0
U2 1
PU SURGICAL TECHNOLOGY INT ONLINE
PI SAN FRANCISCO
PA 2443 FILLMORE ST, 229, SAN FRANCISCO, CA 94115 USA
EI 1090-3941
J9 SURG TECHNOL INT
JI Surg. Technol. Int.
PD MAY
PY 2022
VL 40
AR PII sti40/1523
PG 6
WC Surgery
WE Emerging Sources Citation Index (ESCI)
SC Surgery
GA I6PG2
UT WOS:001003977600006
DA 2025-06-11
ER

PT J
AU Scherer, T
   Sakamoto, K
   Buettner, C
AF Scherer, Thomas
   Sakamoto, Kenichi
   Buettner, Christoph
TI Brain insulin signalling in metabolic homeostasis and disease
SO NATURE REVIEWS ENDOCRINOLOGY
LA English
DT Review
ID CENTRAL-NERVOUS-SYSTEM; REDUCES FOOD-INTAKE; CHRONIC
   INTRACEREBROVENTRICULAR INFUSION; ENDOGENOUS GLUCOSE-PRODUCTION;
   ENDOPLASMIC-RETICULUM STRESS; HEPATIC GLYCOGEN-SYNTHESIS; RANDOMIZED
   CLINICAL-TRIAL; ATP CHANNEL ACTIVATION; BROWN ADIPOSE-TISSUE;
   CEREBRAL-BLOOD-FLOW
AB Insulin signalling in the central nervous system regulates energy homeostasis by controlling metabolism in several organs and by coordinating organ crosstalk. Studies performed in rodents, non-human primates and humans over more than five decades using intracerebroventricular, direct hypothalamic or intranasal application of insulin provide evidence that brain insulin action might reduce food intake and, more importantly, regulates energy homeostasis by orchestrating nutrient partitioning. This Review discusses the metabolic pathways that are under the control of brain insulin action and explains how brain insulin resistance contributes to metabolic disease in obesity, the metabolic syndrome and type 2 diabetes mellitus.
C1 [Scherer, Thomas] Med Univ Vienna, Div Endocrinol & Metab, Dept Med 3, Vienna, Austria.
   [Sakamoto, Kenichi; Buettner, Christoph] Rutgers Robert Wood Johnson Med Sch, Div Endocrinol Metab & Nutr, Dept Med, New Brunswick, NJ 08901 USA.
C3 Medical University of Vienna; Rutgers University System; Rutgers
   University New Brunswick; Rutgers University Biomedical & Health
   Sciences
RP Scherer, T (corresponding author), Med Univ Vienna, Div Endocrinol & Metab, Dept Med 3, Vienna, Austria.; Buettner, C (corresponding author), Rutgers Robert Wood Johnson Med Sch, Div Endocrinol Metab & Nutr, Dept Med, New Brunswick, NJ 08901 USA.
EM thomas.scherer@meduniwien.ac.at; cb1116@rwjms.rutgers.edu
OI Sakamoto, Kenichi/0000-0002-7878-5763; Scherer,
   Thomas/0000-0003-4980-706X
FU Austrian Science Fund (FWF) [KLI782]; Manpei Suzuki Diabetes Foundation;
   NIH [DK074873, DK083568, DK082724]; Austrian Science Fund (FWF) [KLI782]
   Funding Source: Austrian Science Fund (FWF)
FX The authors acknowledge the support of the Austrian Science Fund (FWF)
   grant KLI782 to T.S. and Manpei Suzuki Diabetes Foundation to K.S. and
   the NIH grants DK074873, DK083568 and DK082724 to C.B.
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NR 249
TC 104
Z9 116
U1 6
U2 27
PU NATURE RESEARCH
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 1759-5029
EI 1759-5037
J9 NAT REV ENDOCRINOL
JI Nat. Rev. Endocrinol.
PD AUG
PY 2021
VL 17
IS 8
BP 468
EP 483
DI 10.1038/s41574-021-00498-x
EA JUN 2021
PG 16
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA TJ0UB
UT WOS:000659425200001
PM 34108679
DA 2025-06-11
ER

PT J
AU Prasun, P
AF Prasun, Pankaj
TI COVID-19: A Mitochondrial Perspective
SO DNA AND CELL BIOLOGY
LA English
DT Article
DE COVID-19; SARS-CoV; coronavirus; interferon; mitochondria; oxidative
   stress
ID DYSFUNCTION; ACTIVATION; MECHANISMS; DYNAMICS
AB Coronavirus disease 2019 (COVID-19) is the worst public health crisis of the century. Although we have made tremendous progress in understanding the pathogenesis of this disease, a lot more remains to be learned. Mitochondria appear to be important in COVID-19 pathogenesis because of its role in innate antiviral immunity, as well as inflammation. This article examines pathogenesis of COVID-19 from a mitochondrial perspective and tries to answer some perplexing questions such as why the prognosis is so poor in those with obesity, metabolic syndrome, or type 2 diabetes. Although effective vaccines and antiviral drugs will be the ultimate solution to this crisis, a better understanding of disease mechanisms will open novel avenues for treatment and prevention.
C1 [Prasun, Pankaj] Icahn Sch Med Mt Sinai, Dept Genet & Genom Sci, One Gustave L Levy Pl Box 1497, New York, NY 10029 USA.
C3 Icahn School of Medicine at Mount Sinai
RP Prasun, P (corresponding author), Icahn Sch Med Mt Sinai, Dept Genet & Genom Sci, One Gustave L Levy Pl Box 1497, New York, NY 10029 USA.
EM pankaj.prasun@mssm.edu
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NR 71
TC 23
Z9 23
U1 0
U2 4
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1044-5498
EI 1557-7430
J9 DNA CELL BIOL
JI DNA Cell Biol.
PD JUN 1
PY 2021
VL 40
IS 6
BP 713
EP 719
DI 10.1089/dna.2020.6453
EA APR 2021
PG 7
WC Biochemistry & Molecular Biology; Cell Biology; Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology; Genetics & Heredity
GA SO8MG
UT WOS:000641582600001
PM 33872068
DA 2025-06-11
ER

PT J
AU Eskandarani, RM
   Sawan, S
AF Eskandarani, Rawan M.
   Sawan, Shaima
TI Diabetic Ketoacidosis on Hospitalization with COVID-19 in a Previously
   Nondiabetic Patient: A Review of Pathophysiology
SO CLINICAL MEDICINE INSIGHTS-ENDOCRINOLOGY AND DIABETES
LA English
DT Review
DE Diabetes; Covid-19; Hyperglycemia; SARS-COV-2; Ketoacidosis
ID TUMOR-NECROSIS-FACTOR; RENIN-ANGIOTENSIN SYSTEM; OXIDATIVE STRESS;
   FACTOR-ALPHA; LIPID-PEROXIDATION; CYTOKINE STORM; INTERLEUKIN-6;
   CORONAVIRUS; OBESITY; HYPERGLYCEMIA
AB Hyperglycaemia during inpatient admission is indicative of higher morbidity and mortality risks in critically ill patients. The severe acute respiratory distress coronavirus 2 (SARS-CoV-2) has been reported to induce ketoacidosis and diabetic ketoacidosis (DKA) even in nondiabetic patients. The pathophysiology of the SARS-CoV-2 infection that can contribute to hyperglycaemia, and the exacerbated inflammatory cytokine storm can overlap with the metabolic chronic inflammatory state attributable to the metabolic syndrome, which underlies diabetes mellitus. In this report, we explore the possible pathophysiology and metabolic mechanisms that lead to metabolic acidosis in nondiabetic patients.
C1 [Eskandarani, Rawan M.; Sawan, Shaima] King Fahad Med City, Riyadh, Saudi Arabia.
RP Eskandarani, RM (corresponding author), King Fahad Med City, Emergency Med Adm, Makkah Al Mukarramah Rd, Riyadh 12231, Saudi Arabia.
EM reskandarani@kfmc.med.sa
RI Eskandarani, Rawan/HCH-7889-2022
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NR 45
TC 13
Z9 13
U1 0
U2 2
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1179-5514
J9 CLIN MED INSIGHTS-EN
JI Clin. Med. Insights-Endocrinol. Diabetes
PD DEC
PY 2020
VL 13
AR 1179551420984125
DI 10.1177/1179551420984125
PG 6
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA PL0DY
UT WOS:000602805000001
PM 33488135
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Bozcali, E
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   Himmetoglu, S
   Mihmanli, I
   Toprak, S
AF Bozcali, Evin
   Babalik, Erhan
   Himmetoglu, Solen
   Mihmanli, Ismail
   Toprak, Sadik
TI ω-3 fatty acid treatment in cardiac syndrome X: a double-blind,
   randomized, placebo-controlled clinical study
SO CORONARY ARTERY DISEASE
LA English
DT Article
DE coronary resistance; endothelial dysfunction; lipid peroxidation;
   microvascular angina; oxidative stress
ID NORMAL CORONARY ARTERIOGRAMS; SUPEROXIDE-DISMUTASE ACTIVITY;
   FLOW-MEDIATED VASODILATION; LEFT-VENTRICULAR FUNCTION; ENDOTHELIAL
   DYSFUNCTION; CHEST-PAIN; OXIDATIVE STRESS; MICROVASCULAR ANGINA;
   LIPID-PEROXIDATION; ANTIOXIDANT STATUS
AB Objective We conducted a clinical trial to examine the effect of omega-3 fatty acids in patients with cardiac syndrome X (CSX). We aimed to evaluate the potential impact of omega-3 fatty acids on endothelial function, oxidative stress, and symptom relief in the CSX.
   Methods and results Eighteen patients with CSX were enrolled according to a double-blind, randomized, placebo-controlled design. Patients were randomized to omega-3 fatty acids (1440 mg/day, n = 8) or placebo (n = 10) for 4 months. We assessed plasma levels of malondialdehyde (MDA), endothelium-dependent vasodilatation [flow-mediated dilatation (FMD)], endothelium-independent vasodilatation [nitroglycerin-mediated dilatation (NMD)], and status of symptom [score with Seattle Angina Questionnaire (SAQ)] before and after the treatment. After 4 months, patients who were treated with omega-3 fatty acids showed significant increases in the FMD (from 47 +/- 48 to 104 +/- 23%, P<0.05) and NMD (from 51 +/- 53 to 93 +/- 35%, P<0.05) values, and significant decreases in the plasma MDA levels (4.4 +/- 0.86 to 3.35 +/- 0.33 mu mol/l, P = 0.012). SAQ scores were increased significantly in both groups (from 60 +/- 14 to 73 +/- 15%, P<0.05 placebo, from 67 +/- 0 to 81 +/- 9%, P<0.05 treatment group). NMD was correlated negatively with the plasma MDA levels.
   Conclusion Four months of therapy with a moderate dose of omega-3 fatty acids improved the endothelial function and reduced oxidative stress in patients with CSX. Coron Artery Dis 24:328-333 (c) 2013 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
C1 [Bozcali, Evin] Baltalimani Bone Dis Educ & Res Hosp, Dept Cardiol, Istanbul, Turkey.
   [Babalik, Erhan] Mem Hosp, Dept Cardiol, TR-34385 Istanbul, Turkey.
   [Himmetoglu, Solen] Istanbul Univ, Cerrahpasa Fac Med, Dept Biochem, Istanbul, Turkey.
   [Mihmanli, Ismail] Istanbul Univ, Cerrahpasa Fac Med, Dept Radiol, Istanbul, Turkey.
   [Toprak, Sadik] Bulent Ecevit Univ, Fac Med, Dept Forens Med, Zonguldak, Turkey.
C3 Baltalimani Bone Diseases Training & Research Hospital; Memorial
   Healthcare Group; Istanbul University - Cerrahpasa; Istanbul University;
   Istanbul University; Istanbul University - Cerrahpasa; Zonguldak Bulent
   Ecevit University
RP Babalik, E (corresponding author), Mem Hosp, Dept Cardiol, Piyalepasa Bulvari Okmeydani Sisli, TR-34385 Istanbul, Turkey.
EM erhanbabalik@yahoo.com
RI Bozcali, Evin/HIR-8825-2022; toprak, sadik/AAC-6480-2020
OI Toprak, Sadik/0000-0002-8065-1334
FU Turkish Society of Cardiology [2006-3]; Kocak Farma Pharmaceutical
   Company, Istanbul, Turkey
FX This study was supported by a Research Fund of the Turkish Society of
   Cardiology (fund number 2006-3) and Kocak Farma Pharmaceutical Company,
   Istanbul, Turkey.
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NR 42
TC 8
Z9 9
U1 1
U2 29
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0954-6928
J9 CORONARY ARTERY DIS
JI Coronary Artery Dis.
PD JUN
PY 2013
VL 24
IS 4
BP 328
EP 333
DI 10.1097/MCA.0b013e32835f3005
PG 6
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 133QQ
UT WOS:000318154600011
PM 23425772
DA 2025-06-11
ER

PT J
AU Sabio, G
   Das, M
   Mora, A
   Zhang, ZY
   Jun, JY
   Ko, HJ
   Barrett, T
   Kim, JK
   Davis, RJ
AF Sabio, Guadalupe
   Das, Madhumita
   Mora, Alfonso
   Zhang, Zhiyou
   Jun, John Y.
   Ko, Hwi Jin
   Barrett, Tamera
   Kim, Jason K.
   Davis, Roger J.
TI A Stress Signaling Pathway in Adipose Tissue Regulates Hepatic Insulin
   Resistance
SO SCIENCE
LA English
DT Article
ID NECROSIS-FACTOR-ALPHA; IN-VIVO; INTERLEUKIN-6 DOES/DOES;
   GLUCOSE-HOMEOSTASIS; BENEFICIAL ROLE; OBESITY; SOCS-3; MICE;
   INFLAMMATION; HEPATOCYTES
AB A high-fat diet causes activation of the regulatory protein c-Jun NH(2)-terminal kinase 1 (JNK1) and triggers development of insulin resistance. JNK1 is therefore a potential target for therapeutic treatment of metabolic syndrome. We explored the mechanism of JNK1 signaling by engineering mice in which the Jnk1 gene was ablated selectively in adipose tissue. JNK1 deficiency in adipose tissue suppressed high- fat diet- induced insulin resistance in the liver. JNK1- dependent secretion of the inflammatory cytokine interleukin- 6 by adipose tissue caused increased expression of liver SOCS3, a protein that induces hepatic insulin resistance. Thus, JNK1 activation in adipose tissue can cause insulin resistance in the liver.
C1 [Sabio, Guadalupe; Davis, Roger J.] Univ Massachusetts, Sch Med, Howard Hughes Med Inst, Worcester, MA 01605 USA.
   [Sabio, Guadalupe; Das, Madhumita; Mora, Alfonso; Barrett, Tamera; Davis, Roger J.] Univ Massachusetts, Sch Med, Program Mol Med, Worcester, MA 01605 USA.
   [Jun, John Y.] Penn State Univ, Coll Med, Dept Med, Hershey, PA 17033 USA.
C3 Howard Hughes Medical Institute; University of Massachusetts System;
   University of Massachusetts Worcester; University of Massachusetts
   System; University of Massachusetts Worcester; Pennsylvania Commonwealth
   System of Higher Education (PCSHE); Pennsylvania State University; Penn
   State Health
RP Davis, RJ (corresponding author), Univ Massachusetts, Sch Med, Howard Hughes Med Inst, Worcester, MA 01605 USA.
EM roger.davis@umassmed.edu
RI Mora, Alfonso/D-2759-2017; Sabio, Guadalupe/H-9733-2015
OI Sabio, Guadalupe/0000-0002-2822-0625; Kim, Jason/0000-0002-7185-042X;
   Davis, Roger/0000-0002-0130-1652; Mora, Alfonso/0000-0002-6397-4836
FU NIH; American Diabetes Association [1-04-RA-47]; Pennsylvania State
   Department of Health; Core facilities at the University of
   Massachusetts; National Institute of Diabetes and Digestive and Kidney
   Diseases; Diabetes and Endocrinology Research Center [DK52530]
FX We thank V. Benoit, J. Cavanagh- Kyros, K. Gemme, N. Kennedy, J. Liu,
   and J. Reilly for expert assistance. These studies were supported by
   grants from NIH (to R.J.D.), the American Diabetes Association
   (1-04-RA-47 to J.K.K.), and the Pennsylvania State Department of Health
   (to J.K.K.). Core facilities at the University of Massachusetts used by
   these studies were supported by the National Institute of Diabetes and
   Digestive and Kidney Diseases, Diabetes and Endocrinology Research
   Center (DK52530). R.J.D. is an Investigator of the Howard Hughes Medical
   Institute.
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NR 26
TC 480
Z9 537
U1 3
U2 49
PU AMER ASSOC ADVANCEMENT SCIENCE
PI WASHINGTON
PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA
SN 0036-8075
J9 SCIENCE
JI Science
PD DEC 5
PY 2008
VL 322
IS 5907
BP 1539
EP 1543
DI 10.1126/science.1160794
PG 5
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 379DU
UT WOS:000261377400048
PM 19056984
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Reichert, CL
   Diogo, CL
   Vieira, JL
   Dalacorte, RR
AF Reichert, Cesar L.
   Diogo, Cesar L.
   Vieira, Jose L.
   Dalacorte, Roberta R.
TI Physical activity and depressive symptoms in community-dwelling elders
   from southern Brazil
SO REVISTA BRASILEIRA DE PSIQUIATRIA
LA English
DT Article
DE Aged; Motor activity; Signs and symptoms; Depression; Geriatrics
ID ACTIVITY QUESTIONNAIRE; EXERCISE TREATMENT; METABOLIC SYNDROME;
   MORTALITY; HEALTH; RELIABILITY; PREVALENCE
AB Objective: To determine the existence of a relationship between physical activity and depressive symptoms in community-dwelling elders. Method: This is a cross-sectional, population-based study, which included 379 community-dwelling elders from Novo Hamburgo, state of RS, Brazil. The level of physical activity was estimated using the International Physical Activity Questionnaire and depressive symptoms were diagnosed according to the Yesavage Geriatric Depression Scale. The association between the level of physical activity and depressive symptoms was analyzed by logistic regression. Results: A tendency towards a lower prevalence of depressive symptoms was observed in individuals with higher levels of physical activity, both in the sample as a whole as well as among men, but not among women (p for linear trend 0.04, 0.03 and 0.36, respectively). The odds ratio of the presence of depressive symptoms in the very active group as compared against that of the insufficiently active group was 0.32 (95% CI: 0.12-0.86) for men and 0.76 (95% CI: 0.391.46) for women. Conclusion: In this population of aged individuals, more intense physical activity is related to a lower prevalence of depressive symptoms. As shown by gender stratification, physical activity is inversely related to depressive symptoms in men, albeit not in women.
C1 [Reichert, Cesar L.] Ctr Univ Feevale, Exercise Physiol Lab, Novo Hamburgo, RS, Brazil.
   [Diogo, Cesar L.; Dalacorte, Roberta R.] Pontificia Univ Catolica Rio Grande do Sul, Inst Gerontol & Geriatr, Porto Alegre, RS, Brazil.
   [Vieira, Jose L.] Rio Grande Sul Cardiol Inst, Porto Alegre, RS, Brazil.
C3 Pontificia Universidade Catolica Do Rio Grande Do Sul; Fundacao
   Universitaria de Cardiologia
RP Dalacorte, RR (corresponding author), Inst Geriatria PUCRS, Ave Ipiranga 6690, BR-91530001 Porto Alegre, RS, Brazil.
EM robertarigod@gmail.com
RI Corte, Roberta Rigo Dalla/U-9099-2019
OI Corte, Roberta Rigo Dalla/0000-0002-0296-3666
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NR 40
TC 19
Z9 24
U1 0
U2 4
PU ASSOC BRASILEIRA PSIQUIATRIA
PI SAO PAULO
PA SUBSCRIPTION DEPARTMENT, RUA PEDRO DE TOLEDO, 967 - CASA 01, SAO PAULO,
   SP 04039-032  A, BRAZIL
EI 1809-452X
J9 REV BRAS PSIQUIATR
JI Rev. Bras. Psiquiatr.
PD JUN
PY 2011
VL 33
IS 2
BP 165
EP 170
DI 10.1590/S1516-44462011005000006
PG 6
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 804KN
UT WOS:000293652800012
PM 21829910
OA gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Teixeira, AL
   Martins, LB
   Berk, M
   Bauer, ME
AF Teixeira, Antonio L.
   Martins, Lais B.
   Berk, Michael
   Bauer, Moises E.
TI Severe psychiatric disorders and general medical comorbidities:
   inflammation-related mechanisms and therapeutic opportunities
SO CLINICAL SCIENCE
LA English
DT Review
ID MAJOR DEPRESSIVE DISORDER; INDUCED WEIGHT-GAIN; BIPOLAR DISORDER;
   METABOLIC SYNDROME; T-CELLS; AUTOIMMUNE-DISEASES; MULTIPLE-SCLEROSIS;
   MITOCHONDRIAL DYSFUNCTION; THYROID AUTOIMMUNITY; PSYCHOSOCIAL STRESS
AB Individuals with severe psychiatric disorders, such as mood disorders and schizophrenia, are at increased risk of developing other medical conditions, especially cardiovascular and metabolic diseases. These medical conditions are underdiagnosed and undertreated in these patients contributing to their increased morbidity and mortality. The basis for this increased comorbidity is not well understood, possibly reflecting shared risks factors (e.g. lifestyle risk factors), shared biological mechanisms and/or reciprocal interactions. Among overlapping pathophysiological mechanisms, inflammation and related factors, such as dys-biosis and insulin resistance, stand out. Besides underlying the association between psychi-atric disorders and cardiometabolic diseases, these mechanisms provide several potential therapeutic targets.
C1 [Teixeira, Antonio L.; Martins, Lais B.] Univ Texas Hlth Sci Ctr, Dept Psychiat & Behav Sci, Neuropsychiat Program, Houston, TX 77030 USA.
   [Teixeira, Antonio L.] Fac St Casa BH, Belo Horizonte, Brazil.
   [Berk, Michael] Deakin Univ, Barwon Hlth, IMPACT Inst Mental & Phys Hlth & Clin Translat, Sch Med, Geelong, Australia.
   [Berk, Michael] Univ Melbourne, Florey Inst Neurosci & Mental Hlth, Natl Ctr Excellence Youth Mental Hlth, Orygen,Ctr Youth Mental Hlth, Melbourne, Australia.
   [Berk, Michael] Univ Melbourne, Dept Psychiat, Melbourne, Australia.
   [Bauer, Moises E.] Pontif Catholic Univ Rio Grande Sul PUCRS, Sch Hlth & Life Sci, Lab Immunobiol, Porto Alegre, Brazil.
C3 Baylor College of Medicine; Baylor College Medical Hospital; University
   of Texas System; University of Texas Health Science Center Houston;
   Barwon Health; Deakin University; Florey Institute of Neuroscience &
   Mental Health; University of Melbourne; Orygen, The National Centre of
   Excellence in Youth Mental Health; University of Melbourne; Pontificia
   Universidade Catolica Do Rio Grande Do Sul
RP Teixeira, AL (corresponding author), Univ Texas Hlth Sci Ctr, Dept Psychiat & Behav Sci, Neuropsychiat Program, Houston, TX 77030 USA.; Teixeira, AL (corresponding author), Fac St Casa BH, Belo Horizonte, Brazil.
EM antonio.l.teixeira@uth.tmc.edu
RI Teixeira, Antonio/N-3315-2014; Berk, Michael/AGH-9427-2022; Bauer,
   Moises/J-9195-2015; Berk, Michael/M-7891-2013
OI Bauer, Moises/0000-0003-2957-1352; Berk, Michael/0000-0002-5554-6946;
   Bhering Martins, Lais/0000-0002-9814-8649; Teixeira, Antonio
   Lucio/0000-0002-9621-5422
FU CNPq Research Fellowship; National Institute of Aging; UTHealth
   Department of Psychiatry; NHMRC Senior Principal Research Fellowship
   [1156072]; National Health and Medical Research Council; Wellcome Trust;
   Medical Research Future Fund; Victorian Medical Research Acceleration
   Fund; Centre for Research Excellence CRE; Victorian Government
   Department of Jobs, Precincts and Regions; Texas Alzheimer's Research
   and Care Consortium; Victorian COVID-19 Research Fund
FX A.L.T. and M.E.B. are supported by CNPq Research Fellowship. A.L.T. has
   received grant/research support (last three years) from National
   Institute of Aging, Texas Alzheimer's Research and Care Consortium,
   UTHealth Department of Psychiatry and Behavioral Science. M.B. is
   supported by a NHMRC Senior Principal Research Fellowship [grant number
   1156072] . M.B. has received grant/research support (last three years)
   from National Health and Medical Research Council, Wellcome Trust,
   Medical Research Future Fund, Victorian Medical Research Acceleration
   Fund, Centre for Research Excellence CRE, Victorian Government
   Department of Jobs, Precincts and Regions and Victorian COVID-19
   Research Fund. He received honoraria from Springer, Oxford University
   Press, Cambridge University Press, Allen and Unwin, Lundbeck,
   Controversias Barcelona, Servier, Medisquire, HealthEd, ANZJP, EPA,
   Janssen, Medplan, Milken Institute, RANZCP, Abbott India, ASCP,
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NR 242
TC 10
Z9 10
U1 1
U2 2
PU PORTLAND PRESS LTD
PI LONDON
PA 1ST FLR, 10 QUEEN STREET PLACE, LONDON, ENGLAND
SN 0143-5221
EI 1470-8736
J9 CLIN SCI
JI Clin. Sci.
PD SEP
PY 2022
VL 136
IS 17
BP 1257
EP 1280
DI 10.1042/CS20211106
PG 24
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 4R3AB
UT WOS:000856639200001
PM 36062418
DA 2025-06-11
ER

PT J
AU Demontis, F
   Piccirillo, R
   Goldberg, AL
   Perrimon, N
AF Demontis, Fabio
   Piccirillo, Rosanna
   Goldberg, Alfred L.
   Perrimon, Norbert
TI The influence of skeletal muscle on systemic aging and lifespan
SO AGING CELL
LA English
DT Review
DE exercise; intertissue communication during aging; myokine signaling;
   skeletal muscle aging; systemic aging
ID MYOSTATIN INHIBITION; GLUCOSE-HOMEOSTASIS; DIETARY RESTRICTION;
   ALZHEIMERS-DISEASE; ENERGY-METABOLISM; FLIGHT ACTIVITY; EXERCISE; AGE;
   MICE; LONGEVITY
AB Epidemiological studies in humans suggest that skeletal muscle aging is a risk factor for the development of several age-related diseases such as metabolic syndrome, cancer, Alzheimer's and Parkinson's disease. Here, we review recent studies in mammals and Drosophila highlighting how nutrient- and stress-sensing in skeletal muscle can influence lifespan and overall aging of the organism. In addition to exercise and indirect effects of muscle metabolism, growing evidence suggests that muscle-derived growth factors and cytokines, known as myokines, modulate systemic physiology. Myokines may influence the progression of age-related diseases and contribute to the intertissue communication that underlies systemic aging.
C1 [Demontis, Fabio; Perrimon, Norbert] Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA.
   [Demontis, Fabio] St Jude Childrens Res Hosp, Dept Dev Neurobiol, Div Dev Biol, Memphis, TN 38105 USA.
   [Piccirillo, Rosanna; Goldberg, Alfred L.] Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA.
   [Piccirillo, Rosanna] IRCCS, Mario Negri Inst Pharmacol Res, Dept Oncol, Milan, Italy.
   [Perrimon, Norbert] Harvard Univ, Sch Med, Howard Hughes Med Inst, Boston, MA 02115 USA.
C3 Harvard University; Harvard Medical School; St Jude Children's Research
   Hospital; Harvard University; Harvard Medical School; Istituto di
   Ricerche Farmacologiche Mario Negri IRCCS; Harvard University; Harvard
   Medical School; Howard Hughes Medical Institute
RP Demontis, F (corresponding author), St Jude Childrens Res Hosp, Dept Dev Neurobiol, 262 Danny Thomas Pl,MS324, Memphis, TN 38105 USA.
EM Fabio.Demontis@stjude.org
RI Piccirillo, Rosanna/AAQ-3653-2020; Perrimon, Norbert/F-9766-2011;
   Piccirillo, Rosanna/K-6619-2016
OI Demontis, Fabio/0000-0002-8698-9555; Perrimon,
   Norbert/0000-0001-7542-472X; Piccirillo, Rosanna/0000-0002-1613-9352
FU ALSAC; MDA; NIH [AR055255, R01AR057352]; AIRC-Start Up [11423]
FX This work was supported by funding to FD from ALSAC, to ALG from the MDA
   and the NIH (AR055255), to RP from AIRC-Start Up (11423), and to NP from
   the NIH (R01AR057352). The authors declare that they have no competing
   interests.
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NR 110
TC 172
Z9 186
U1 0
U2 49
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1474-9718
EI 1474-9726
J9 AGING CELL
JI Aging Cell
PD DEC
PY 2013
VL 12
IS 6
BP 943
EP 949
DI 10.1111/acel.12126
PG 7
WC Cell Biology; Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Geriatrics & Gerontology
GA 255AN
UT WOS:000327211700001
PM 23802635
OA hybrid, Green Accepted
DA 2025-06-11
ER

PT J
AU Boden, G
AF Boden, Guenther
TI Obesity and Free Fatty Acids
SO ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA
LA English
DT Article
ID ENDOPLASMIC-RETICULUM STRESS; GLUT4 GENE-EXPRESSION; PROTEIN-KINASE-C;
   INSULIN-RESISTANCE; MATRIX METALLOPROTEINASES; GLUCOSE-TOLERANCE;
   ADIPOSE-TISSUE; ACTIVATION; RECEPTOR; PATHWAYS
AB Plasma free fatty acid (FFA) levels are elevated in obesity. FFAs cause insulin resistance in all major insulin target organs (skeletal muscle, liver, endothelial cells) and have emerged as a major link between obesity, the development of the metabolic syndrome, and atherosclerotic vascular disease. FFAs also produce low-grade inflammation in skeletal muscle, liver, and fat, which may contribute to cardiovascular events. The challenges for the future include the prevention or correction of obesity and elevated plasma FFA levels through methods that include decreased caloric intake and increased caloric expenditure, the development of methods to measure FFAs in small blood samples, and the development of efficient pharmacologic approaches to normalize increased plasma FFA levels.
C1 Temple Univ, Temple Univ Hosp, Sch Med, Dept Med,Div Endocrinol Diabet Metab, Philadelphia, PA 19140 USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE); Temple
   University
RP Boden, G (corresponding author), Temple Univ, Temple Univ Hosp, Sch Med, Dept Med,Div Endocrinol Diabet Metab, 3401 N Broad St, Philadelphia, PA 19140 USA.
EM bodengh@tuhs.temple.edu
FU National Institutes of Health [RO1-DK-68895, RO1-HL-733267,
   RO1-DK-066003]
FX This work was supported by National Institutes of Health grants
   RO1-DK-68895, RO1-HL-733267, and RO1-DK-066003.
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NR 59
TC 637
Z9 733
U1 1
U2 55
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0889-8529
EI 1558-4410
J9 ENDOCRIN METAB CLIN
JI Endocrinol. Metabol. Clin. North Amer.
PD SEP
PY 2008
VL 37
IS 3
BP 635
EP +
DI 10.1016/j.ecl.2008.06.007
PG 14
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 357WJ
UT WOS:000259877600007
PM 18775356
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Alberti, A
AF Alberti, Alfredo
TI What are the comorbidities influencing the management of patients and
   the response to therapy in chronic hepatitis C?
SO LIVER INTERNATIONAL
LA English
DT Article
DE comorbidities; depression; hepatitis C; HCV; insulin resistance
ID PEGYLATED INTERFERON-ALPHA; PLUS RIBAVIRIN; INITIAL TREATMENT;
   VIRUS-INFECTION; DEPRESSION; SYMPTOMS
AB The natural history of chronic hepatitis C has been defined in several retrospective and prospective studies conducted in the last 20 years. These studies have clearly demonstrated that the outcome of chronic hepatitis C virus infection is profoundly influenced by a variety of cofactors and comorbidities. Many of the cofactors that affect the course of liver disease in hepatitis C also have a significant influence on the result of antiviral therapy. Unfortunately, comorbidities that have been shown to negatively influence the course and outcome of liver disease often reduce the chance of achieving a sustained virological response with pegylated interferon (PEG-IFN) and ribavirin treatment. The most important and frequent comorbidity influencing the course of chronic hepatitis C and the response to antiviral therapy is represented by the metabolic syndrome, and by the associated state of insulin resistance. Other comorbidities that have a negative influence on the progression of hepatitis C and on the response to antiviral therapy include excess alcohol intake, human immunodeficiency virus and hepatitis B virus co-infection and a number of conditions that reduce the benefit of therapy by affecting negatively compliance and/or adherence to adequate PEG-IFN or ribavirin doses.
C1 Univ Padua, Venetian Inst Mol Med, Dept Histol Microbiol & Med Biotechnol, I-35128 Padua, Italy.
C3 University of Padua; Veneto Institute Molecular Medicine
RP Alberti, A (corresponding author), Univ Padua, Venetian Inst Mol Med, Dept Histol Microbiol & Med Biotechnol, Via Orus 2, I-35128 Padua, Italy.
EM alfredo.alberti@unipd.it
OI ALBERTI, ALFREDO/0000-0001-9926-2382
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NR 23
TC 40
Z9 48
U1 0
U2 2
PU WILEY-BLACKWELL PUBLISHING, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1478-3223
J9 LIVER INT
JI Liver Int.
PD JAN
PY 2009
VL 29
SU 1
BP 15
EP 18
DI 10.1111/j.1478-3231.2008.01945.x
PG 4
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 397FB
UT WOS:000262646800003
PM 19207961
OA Bronze
DA 2025-06-11
ER

PT J
AU Velasquez, MT
   Katz, JD
AF Velasquez, Manuel T.
   Katz, James D.
TI Osteoarthritis: Another Component of Metabolic Syndrome?
SO METABOLIC SYNDROME AND RELATED DISORDERS
LA English
DT Article
ID GROWTH-FACTOR-I; C-REACTIVE PROTEIN; GLYCATION END-PRODUCTS; NF-KAPPA-B;
   NITRIC-OXIDE SYNTHASE; RESPONSIVE TRANSCRIPTION FACTOR; ARTICULAR
   CHONDROCYTES EXPRESS; CARDIOVASCULAR-DISEASE RISK;
   NECROSIS-FACTOR-ALPHA; BONE-MARROW LESIONS
AB Osteoarthritis (OA) has become a major public health problem not only because of its increasing prevalence worldwide but also because of its frequent association with cardiovascular disease, the leading cause of death in industrialized countries. There is growing evidence that OA is not simply a disease related to aging or mechanical stress of joints but rather a "metabolic disorder" in which various interrelated lipid, metabolic, and humoral mediators contribute to the initiation and progression of the disease process. Indeed, OA has been linked not only to obesity but also to other cardiovascular risk factors, namely, diabetes, dyslipidemia, hypertension, and insulin resistance.
C1 [Velasquez, Manuel T.] George Washington Univ, Div Renal Dis & Hypertens, Washington, DC 20037 USA.
   [Katz, James D.] George Washington Univ, Div Rheumatol, Washington, DC 20037 USA.
C3 George Washington University; George Washington University
RP Velasquez, MT (corresponding author), George Washington Univ, Div Renal Dis & Hypertens, 2150 Penn Ave,NW, Washington, DC 20037 USA.
EM mvelasquez@mfa.gwu.edu; jkatz@mfa.gwu.edu
RI Katz, James/ABB-8247-2020
OI Katz, James/0000-0002-2098-8883
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NR 155
TC 109
Z9 122
U1 0
U2 12
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-4196
EI 1557-8518
J9 METAB SYNDR RELAT D
JI Metab. Syndr. Relat. Disord.
PD AUG
PY 2010
VL 8
IS 4
BP 295
EP 305
DI 10.1089/met.2009.0110
PG 11
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 637GA
UT WOS:000280803500002
PM 20367223
DA 2025-06-11
ER

PT J
AU Vancampfort, D
   Wyckaert, S
   Sienaert, P
   De Hert, M
   Soundy, A
   Rosenbaum, S
   Richards, J
   Probst, M
AF Vancampfort, Davy
   Wyckaert, Sabine
   Sienaert, Pascal
   De Hert, Marc
   Soundy, Andrew
   Rosenbaum, Simon
   Richards, Justin
   Probst, Michel
TI TEST-RETEST STUDY OF THE SIX-MINUTE WALK TEST IN PEOPLE WITH BIPOLAR
   DISORDER
SO PSYCHIATRIA DANUBINA
LA English
DT Article
DE exercise; walking; pain; depression; bipolar disorder; the 6-minute walk
   test
ID METABOLIC SYNDROME; METAANALYSIS; CONSENSUS
AB Background: The multidisciplinary care for bipolar disorder is highly fragmented with limited opportunities for prevention and treatment of medical co-morbidities. We examined the reliability of the 6-minute walk test (6MWT). Secondary aims were to assess minimal detectable changes (MDC95), practice effects and the impact of clinical conditions.
   Subjects and methods: Two 6MWTs were administered within 3 days to 46 (23 male) inpatients with a DSM-V diagnosis of bipolar disorder. Physical complaints before and after the 6MWT were recorded. Patients completed the Quick Inventory of Depressive Symptomatology Self Report (QIDS-SR) and Hypomania Check List-32.
   Results: Patients walked 594.7 +/- 121.3 meters and 600.0 +/- 122.9 meters at the first and second test. The intraclass correlation coefficient was 0.98 (95% confidence interval 0.97-0.99). The MDC95 was 37.8 meters for men and 52.9 meters for women. No practice effect was detected. Longer illness duration, higher QIDS-SR scores and the presence of feet or ankle static problems or pain were independently related to shorter 6MWT distance accounting for 59.8% of the variance.
   Conclusion: The 6MWT is a clinically feasible tool for evaluating the functional exercise capacity in patients with bipolar disorder. Health care professionals should consider depression and physical pain when developing rehabilitation programmes.
C1 [Vancampfort, Davy; Wyckaert, Sabine; Sienaert, Pascal; De Hert, Marc; Probst, Michel] KU Leuven Univ Leuven, Dept Rehabil Sci, Leuven, Belgium.
   [Vancampfort, Davy; Wyckaert, Sabine; Sienaert, Pascal; De Hert, Marc; Probst, Michel] KU Leuven Univ Leuven, Leuven Kortenberg, Belgium.
   [Soundy, Andrew] Univ Birmingham, Sch Sport Exercise & Rehabil Sci, Birmingham, W Midlands, England.
   [Rosenbaum, Simon] Univ New South Wales, Sch Psychiat, Sydney, NSW, Australia.
   [Richards, Justin] Univ Sydney, Sch Publ Hlth, Sydney, NSW, Australia.
   [Richards, Justin] Univ Sydney, Charles Perkins Ctr, Sydney, NSW, Australia.
C3 KU Leuven; KU Leuven; University of Birmingham; University of New South
   Wales Sydney; University of Sydney; University of Sydney
RP Vancampfort, D (corresponding author), KU Leuven Univ Leuven, Dept Rehabil Sci, Leuvensesteenweg 517, B-3070 Kortenberg, Belgium.
EM Davy.Vancampfort@uc-kortenberg.be
RI Soundy, Andrew/H-3407-2019; Vancampfort, Davy/AAD-1987-2019; De Hert,
   Marc/AAH-6090-2021; sienaert, pascal/HTP-4217-2023; Rosenbaum,
   Simon/Y-3241-2019; Probst, Michel/ABE-6137-2020
OI Richards, Justin/0000-0003-4584-8614; De Hert, Marc/0000-0003-4255-5920;
   Soundy, Andrew/0000-0002-5118-5872; Rosenbaum,
   Simon/0000-0002-8984-4941; Sienaert, Pascal/0000-0002-0650-415X
CR Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
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NR 24
TC 9
Z9 9
U1 0
U2 0
PU MEDICINSKA NAKLADA
PI ZAGREB
PA VLASKA 69, HR-10000 ZAGREB, CROATIA
SN 0353-5053
EI 1849-0867
J9 PSYCHIAT DANUB
JI Psychiatr. Danub.
PY 2016
VL 28
IS 1
BP 39
EP 44
PG 6
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA DU0FP
UT WOS:000381877700005
PM 26938820
DA 2025-06-11
ER

PT J
AU Balasubramanian, P
   Kiss, T
   Tarantini, S
   Nyúl-Tóth, A
   Ahire, C
   Yabluchanskiy, A
   Csipo, T
   Lipecz, A
   Tabak, A
   Institoris, A
   Csiszar, A
   Ungvari, Z
AF Balasubramanian, Priya
   Kiss, Tamas
   Tarantini, Stefano
   Nyul-Toth, Adam
   Ahire, Chetan
   Yabluchanskiy, Andriy
   Csipo, Tamas
   Lipecz, Agnes
   Tabak, Adam
   Institoris, Adam
   Csiszar, Anna
   Ungvari, Zoltan
TI Obesity-induced cognitive impairment in older adults: a microvascular
   perspective
SO AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
LA English
DT Review
DE aging; endothelial dysfunction; metabolic syndrome; senescence
ID BLOOD-BRAIN-BARRIER; HIGH-FAT DIET; BODY-MASS INDEX; TERM CALORIC
   RESTRICTION; PHYSICAL-ACTIVITY INTERVENTION; VASCULAR OXIDATIVE STRESS;
   LIFE-STYLE INTERVENTION; ENDOTHELIAL-CELLS; ADIPOSE-TISSUE; RISK-FACTORS
AB Over two-thirds of individuals aged 65 and older are obese or overweight in the United States. Epidemiological data show an association between the degree of adiposity and cognitive dysfunction in the elderly. In this review, the pathophysiological roles of microvascular mechanisms, including impaired endothelial function and neurovascular coupling responses, microvascular rarefaction, and blood-brain barrier disruption in the genesis of cognitive impairment in geriatric obesity are considered. The potential contribution of adipose-derived factors and fundamental cellular and molecular mechanisms of senescence to exacerbated obesity-induced cerebromicrovascular impairment and cognitive decline in aging are discussed.
C1 [Balasubramanian, Priya; Kiss, Tamas; Tarantini, Stefano; Nyul-Toth, Adam; Ahire, Chetan; Yabluchanskiy, Andriy; Csipo, Tamas; Lipecz, Agnes; Csiszar, Anna; Ungvari, Zoltan] Univ Oklahoma, Hlth Sci Ctr, Dept Biochem & Mol Biol,Vasc Cognit Impairment &, Reynolds Oklahoma Ctr Aging,Ctr Gerosci & Hlth Br, Oklahoma City, OK 73190 USA.
   [Kiss, Tamas; Csiszar, Anna; Ungvari, Zoltan] Univ Szeged, Theoret Med Doctoral Sch, Dept Med Phys, Int Training Program Gerosci, Szeged, Hungary.
   [Kiss, Tamas; Csiszar, Anna; Ungvari, Zoltan] Univ Szeged, Dept Informat & Cell Biol, Szeged, Hungary.
   [Kiss, Tamas; Csiszar, Anna; Ungvari, Zoltan] Univ Szeged, Dept Mol Med, Szeged, Hungary.
   [Tarantini, Stefano; Csipo, Tamas; Lipecz, Agnes; Tabak, Adam; Ungvari, Zoltan] Semmelweis Univ, Doctoral Sch Basic & Translat Med, Dept Publ Hlth, Int Training Program Gerosci, Budapest, Hungary.
   [Tarantini, Stefano; Ungvari, Zoltan] Univ Oklahoma, Hlth Sci Ctr, Hudson Coll Publ Hlth, Dept Hlth Promot Sci, Oklahoma City, OK 73104 USA.
   [Nyul-Toth, Adam] Biol Res Ctr, Inst Biophys, Int Training Program Gerosci, Szeged, Hungary.
   [Csipo, Tamas] Univ Debrecen, Fac Med, Dept Cardiol, Div Clin Physiol,Int Training Program Gerosci, Debrecen, Hungary.
   [Tabak, Adam] Semmelweis Univ, Fac Med, Dept Internal Med & Oncol, Budapest, Hungary.
   [Tabak, Adam] UCL, Dept Epidemiol & Publ Hlth, London, England.
   [Institoris, Adam] Univ Calgary, Cumming Sch Med, Hotchkiss Brain Inst, Dept Physiol & Pharmacol, Calgary, AB, Canada.
C3 University of Oklahoma System; University of Oklahoma Health Sciences
   Center; Szeged University; Szeged University; Szeged University;
   Semmelweis University; University of Oklahoma System; University of
   Oklahoma Health Sciences Center; HUN-REN; HUN-REN Biological Research
   Center; Institute of Biophysics - HAS; University of Debrecen;
   Semmelweis University; University of London; University College London;
   University of Calgary
RP Ungvari, Z (corresponding author), Univ Oklahoma, Hlth Sci Ctr, Dept Biochem & Mol Biol,Vasc Cognit Impairment &, Reynolds Oklahoma Ctr Aging,Ctr Gerosci & Hlth Br, Oklahoma City, OK 73190 USA.; Ungvari, Z (corresponding author), Univ Szeged, Theoret Med Doctoral Sch, Dept Med Phys, Int Training Program Gerosci, Szeged, Hungary.; Ungvari, Z (corresponding author), Univ Szeged, Dept Informat & Cell Biol, Szeged, Hungary.; Ungvari, Z (corresponding author), Univ Szeged, Dept Mol Med, Szeged, Hungary.; Ungvari, Z (corresponding author), Semmelweis Univ, Doctoral Sch Basic & Translat Med, Dept Publ Hlth, Int Training Program Gerosci, Budapest, Hungary.; Ungvari, Z (corresponding author), Univ Oklahoma, Hlth Sci Ctr, Hudson Coll Publ Hlth, Dept Hlth Promot Sci, Oklahoma City, OK 73104 USA.
EM zoltan-ungvari@ouhsc.edu
RI Tarantini, Stefano/JMQ-7733-2023; Balasubramanian, Priya/AAP-2495-2021;
   Csipo, Tamas/GWR-0012-2022; Ungvari, Zoltan/GZK-8127-2022; Tabak,
   Adam/A-5007-2012
OI Yabluchanskiy, Andriy/0000-0002-9648-7161; Tabak,
   Adam/0000-0002-6234-3936; Balasubramanian, Priya/0000-0003-0912-5363;
   Ahire, Chetan/0000-0003-1034-2031
FU Oklahoma Center for the Advancement of Science and Technology; National
   Institute on Aging (NIA) [R01-AG047879, R01-AG038747, R01-AG055395,
   R01-AG068295]; National Institute of Neurological Disorders and Stroke
   [R01-NS056218, R01-NS100782]; National Institute of General Medical
   Sciences Oklahoma Shared Clinical and Translational Resources
   [GM104938]; Presbyterian Health Foundation; Oklahoma Nathan Shock Center
   [P30AG050911]; Cellular and Molecular GeroScience CoBRE [1P20GM125528,
   5337]; NIA [T32AG052363]; National Institute on Aging [R01AG055395]
   Funding Source: NIH RePORTER
FX This work was supported by grants from the Oklahoma Center for the
   Advancement of Science and Technology (to A. Csiszar, A. Yabluchanskiy,
   and Z. Ungvari), the National Institute on Aging (NIA; R01-AG047879;
   R01-AG038747; R01-AG055395; R01-AG068295), the National Institute of
   Neurological Disorders and Stroke (R01-NS056218, R01-NS100782), the
   National Institute of General Medical Sciences Oklahoma Shared Clinical
   and Translational Resources (GM104938, to A. Yabluchanskiy), the
   Presbyterian Health Foundation, the NIA-supported Geroscience Training
   Program in Oklahoma (T32AG052363), the Oklahoma Nathan Shock Center
   (P30AG050911), the Cellular and Molecular GeroScience CoBRE
   (1P20GM125528, sub#5337).
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NR 323
TC 73
Z9 75
U1 2
U2 31
PU AMER PHYSIOLOGICAL SOC
PI Rockville
PA 6120 Executive Blvd, Suite 600, Rockville, MD, UNITED STATES
SN 0363-6135
EI 1522-1539
J9 AM J PHYSIOL-HEART C
JI Am. J. Physiol.-Heart Circul. Physiol.
PD FEB
PY 2021
VL 320
IS 2
BP H740
EP H761
DI 10.1152/ajpheart.00736.2020
PG 22
WC Cardiac & Cardiovascular Systems; Physiology; Peripheral Vascular
   Disease
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Cardiovascular System & Cardiology; Physiology
GA QZ7BN
UT WOS:000630876800012
PM 33337961
OA Green Published
DA 2025-06-11
ER

PT J
AU Agustini, B
   Lotfaliany, M
   Woods, RL
   McNeil, JJ
   Nelson, MR
   Shah, RC
   Murray, AM
   Ernst, ME
   Reid, CM
   Tonkin, A
   Lockery, JE
   Williams, LJ
   Berk, M
   Mohebbi, M
AF Agustini, Bruno
   Lotfaliany, Mojtaba
   Woods, Robyn L.
   McNeil, John J.
   Nelson, Mark R.
   Shah, Raj C.
   Murray, Anne M.
   Ernst, Michael E.
   Reid, Christopher M.
   Tonkin, Andrew
   Lockery, Jessica E.
   Williams, Lana J.
   Berk, Michael
   Mohebbi, Mohammadreza
CA ASPREE Investigator Grp
TI Patterns of Association between Depressive Symptoms and Chronic Medical
   Morbidities in Older Adults
SO JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
LA English
DT Article
DE depression; late-life depression; medical comorbidity; somatic
   conditions; polypharmacy
ID PRIMARY-CARE PATIENTS; LATE-LIFE DEPRESSION; PRACTICAL APPROACH;
   REDUCING EVENTS; SHORT-FORM; METAANALYSIS; PREVALENCE; DISEASE;
   MULTIMORBIDITY; PARTICIPANTS
AB OBJECTIVES To investigate the association between depressive symptoms and several medical morbidities, and their combination, in a large older population.
   DESIGN Cross-sectional study of baseline data from the ASPirin in Reducing Events in the Elderly (ASPREE) trial.
   SETTING Multicentric study conducted in Australia and the United States.
   PARTICIPANTS A total of 19,110 older adults (mean age = 75 years [standard deviation = +/- 4.5]).
   MEASUREMENTS Depressive symptoms were measured using the Center for Epidemiological Studies Depression (CES-D 10) scale. Medical morbidities were defined according to condition-specific methods. Logistic regression was used to calculate odds ratios (ORs) with 95% confidence intervals (CIs) to test associations before and after accounting for possible confounders.
   RESULTS Depressive symptoms were significantly associated with obesity (OR = 1.19; 95% CI = 1.07-1.32), diabetes (OR = 1.22; 95% CI = 1.05-1.42), gastroesophageal reflux disease (GERD) (OR = 1.41; 95% CI = 1.28-1.57), metabolic syndrome (OR = 1.16; 95% CI = 1.03-1.29), osteoarthritis (OR = 1.41; 95% CI = 1.27-1.57), respiratory conditions (OR = 1.25; 95% CI = 1.10-1.42), history of cancer (OR = 1.19; 95% CI = 1.05-1.34), Parkinson's disease (OR = 2.56; 95% CI = 1.83-3.56), polypharmacy (OR = 1.60; 95% CI = 1.44-1.79), and multimorbidity (OR = 1.29; 95% CI = 1.12-1.49). No significant association was observed between depressive symptoms and hypertension, chronic kidney disease, dyslipidemia, and gout (P > .05). A significant dose-response relationship was evident between the number of medical comorbidities and the prevalence of depression (OR = 1.18; 95% CI = 1.13-1.22).
   CONCLUSION Late-life depressive symptoms are significantly associated with several medical morbidities, and there appears to be a cumulative effect of the number of somatic diseases on the prevalence of depression. These findings augment the evidence for a complex relationship between mental and physical health in an otherwise healthy older population and might guide clinicians toward early recognition of high-risk individuals.
C1 [Agustini, Bruno; Williams, Lana J.; Berk, Michael; Mohebbi, Mohammadreza] Deakin Univ, Sch Med, IMPACT Inst Mental & Phys Hlth & Clin Translat, Barwon Hlth, Geelong, Vic, Australia.
   [Lotfaliany, Mojtaba; Mohebbi, Mohammadreza] Deakin Univ, Biostat Unit, Geelong, Vic, Australia.
   [Woods, Robyn L.; McNeil, John J.; Reid, Christopher M.; Tonkin, Andrew; Lockery, Jessica E.; Berk, Michael] Monash Univ, Sch Publ Hlth & Prevent Med, Melbourne, Vic, Australia.
   [Nelson, Mark R.] Univ Tasmania, Menzies Inst Med Res, Hobart, Tas, Australia.
   [Shah, Raj C.] Rush Univ, Dept Family Med, Med Ctr, Chicago, IL USA.
   [Shah, Raj C.] Rush Univ, Rush Alzheimers Dis Ctr, Med Ctr, Chicago, IL USA.
   [Murray, Anne M.] Hennepin Healthcare, Hennepin Healthcare Res Inst, Berman Ctr Outcomes & Clin Res, Minneapolis, MN USA.
   [Ernst, Michael E.] Univ Iowa, Coll Pharm, Dept Pharm Practice & Sci, Iowa City, IA 52242 USA.
   [Ernst, Michael E.] Univ Iowa, Carver Coll Med, Dept Family Med, Iowa City, IA 52242 USA.
   [Reid, Christopher M.] Curtin Univ, Sch Publ Hlth, Perth, WA, Australia.
   [Berk, Michael] Univ Melbourne, Orygen, Dept Psychiat, Victoria, Australia.
   [Berk, Michael] Univ Melbourne, Florey Inst Neurosci & Mental Hlth, Victoria, Australia.
C3 Barwon Health; Deakin University; Deakin University; Monash University;
   University of Tasmania; Menzies Institute for Medical Research; Rush
   University; Rush University; University of Iowa; University of Iowa;
   Curtin University; University of Melbourne; University of Melbourne;
   Florey Institute of Neuroscience & Mental Health
RP Agustini, B (corresponding author), Deakin Univ, Sch Med, IMPACT Inst Mental & Phys Hlth & Clin Translat, POB 281, Geelong, Vic 3220, Australia.
EM bagustini@deakin.edu.au
RI Reid, Christopher/AAP-8135-2021; Lotfaliany, Mojtaba/ABB-6325-2020;
   McNeil, John/L-6440-2019; Ryan, Joanne/AAB-8324-2019; Shah,
   Raj/AAS-2210-2021; Berk, Michael/AGH-9427-2022; Ernst,
   Erika/O-5111-2019; Woods, Robyn/K-8365-2016; Berk, Michael/M-7891-2013
OI Berk, Michael/0000-0002-5554-6946; Woods, Robyn/0000-0003-1249-6149;
   Lockery, Jessica Elisabeth/0000-0001-6664-1239; Lotfaliany Abrand Abadi,
   Mojtaba/0000-0001-6594-9004; Agustini, Bruno/0000-0001-8735-2401; Ernst,
   Michael/0000-0003-0267-4888; Volpi, Elena/0000-0001-8776-0384; Reid,
   Christopher/0000-0001-9173-3944; McNeil, John/0000-0002-1049-5129; Shah,
   Raj/0000-0001-9706-9730
FU National Health and Medical Research Council (NHMRC) [1064272]; NHMRC
   [1174060, 1059660, 1156072, 1045862]; National Institute on Aging
   [P30AG024824] Funding Source: NIH RePORTER
FX Lana J. Williams is supported by a National Health and Medical Research
   Council (NHMRC) Career Development Fellowship (1064272) and NHMRC
   Investigator grant (1174060). Michael Berk is supported by NHMRC Senior
   Principal Research Fellowships 1059660 and 1156072. Christopher M. Reid
   is supported by an NHMRC Senior Research Fellowship (1045862).
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NR 44
TC 50
Z9 54
U1 1
U2 17
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0002-8614
EI 1532-5415
J9 J AM GERIATR SOC
JI J. Am. Geriatr. Soc.
PD AUG
PY 2020
VL 68
IS 8
BP 1834
EP 1841
DI 10.1111/jgs.16468
EA MAY 2020
PG 8
WC Geriatrics & Gerontology; Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA MZ2CQ
UT WOS:000532523000001
PM 32402115
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Herbet, M
   Gawronska-Grzywacz, M
   Izdebska, M
   Piatkowska-Chmiel, I
   Jagiello-Wójtowicz, E
AF Herbet, Mariola
   Gawronska-Grzywacz, Monika
   Izdebska, Magdalena
   Piatkowska-Chmiel, Iwona
   Jagiello-Wojtowicz, Ewa
TI Impact of combined treatment with rosuvastatin and antidepressants on
   liver and kidney function in rats
SO EXPERIMENTAL AND THERAPEUTIC MEDICINE
LA English
DT Article
DE rosuvastatin; amitriptyline; fluoxetine; biochemical parameters; liver;
   kidney
ID DEPRESSED-PATIENTS; FLUOXETINE; SAFETY; STATINS
AB Depression is among the most prevalent and life-threatening forms of mental illness, and is also a risk factor for cardiovascular disorders, diabetes and metabolic syndrome. Elderly patients commonly receive statins for the prevention of cardiovascular diseases, and antidepressant drugs for the treatment of depression. It should be noted that long-term polypharmacotherapy may lead to potential drug interactions and disorders of the organs. The aim of the present study was to determine whether, and to what extent, combined treatment with rosuvastatin and antidepressants (amitriptyline or fluoxetine) influences the biochemical markers of liver and kidney function in a rat model. For this purpose, the activity levels of aspartate aminotransferase, alanine aminotransferase (ALT), gamma-glutamyltransferase (GGT) and the concentrations of total protein, urea, creatinine and beta(2)-microglobulin were determined. The results of the study indicated that combined treatment with rosuvastatin and the antidepressants amitriptyline and fluoxetine for 14 days altered the activity levels of ALT and GGT, and the concentrations of urea and creatinine in the serum compared with groups of rats receiving rosuvastatin or either antidepressant alone. These observed changes in biochemical parameters may suggest the possibility of impaired liver and kidney function during the continuous combined exposure to the drugs. However, further clinical and animal studies are required in order to further elucidate this process.
C1 [Herbet, Mariola; Gawronska-Grzywacz, Monika; Izdebska, Magdalena; Piatkowska-Chmiel, Iwona; Jagiello-Wojtowicz, Ewa] Med Univ Lublin, Chair & Dept Toxicol, 8 Chodzki St, PL-20093 Lublin, Poland.
C3 Medical University of Lublin
RP Gawronska-Grzywacz, M (corresponding author), Med Univ Lublin, Chair & Dept Toxicol, 8 Chodzki St, PL-20093 Lublin, Poland.
EM monika.grzywacz@umlub.pl
RI Izdebska, Magdalena/AAF-3848-2020
OI Gawronska-Grzywacz, Monika/0000-0003-0236-2825; Piatkowska-Chmiel,
   Iwona/0000-0003-1829-6981; Herbet, Mariola/0000-0001-8975-8093;
   Izdebska, Magdalena/0000-0001-5999-4300
FU Medical University of Lublin [DS38/2013-2014]
FX The present study was supported by a grant from the Medical University
   of Lublin (grant no. DS38/2013-2014).
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NR 29
TC 6
Z9 6
U1 0
U2 7
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1792-0981
EI 1792-1015
J9 EXP THER MED
JI Exp. Ther. Med.
PD APR
PY 2016
VL 11
IS 4
BP 1459
EP 1464
DI 10.3892/etm.2016.3068
PG 6
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA DH3TN
UT WOS:000372709800050
PM 27073465
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Bus, BAA
   Tendolkar, I
   Franke, B
   de Graaf, J
   Den Heijer, M
   Buitelaar, JK
   Voshaar, RCO
AF Bus, Boudewijn A. A.
   Tendolkar, Indira
   Franke, Barbara
   de Graaf, Jacqueline
   Den Heijer, Martin
   Buitelaar, Jan K.
   Voshaar, Richard C. Oude
TI Serum brain-derived neurotrophic factor: Determinants and relationship
   with depressive symptoms in a community population of middle-aged and
   elderly people
SO WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
LA English
DT Article
DE Depression; neurodegenerative disease; brain-derived neurotrophic factor
   (BDNF); age; gender
ID FACTOR BDNF; METABOLIC SYNDROME; FEMALE-PATIENTS; FACTOR LEVEL; DISEASE;
   METAANALYSIS; VAL66MET
AB Objectives. Brain-derived neurotrophic factor (BDNF) is involved in major depressive disorder and neurodegenerative diseases. Clinical studies, showing decreased serum BDNF levels, are difficult to interpret due to limited knowledge of potential confounders and mixed results for age and sex effects. We explored potential determinants of serum BDNF levels in a community sample of 1230 subjects. Methods. Multiple linear regression analyses with serum BDNF level as the dependent variable were conducted to explore the effect of four categories of potential BDNF determinants (sampling characteristics, sociodemographic variables, lifestyle factors and somatic diseases) and of self-reported depressive symptoms (Beck's Depression Inventory (BDI). Results. Our results show that BDNF levels decline with age in women, whereas in men levels remain stable. Moreover, after controlling for age and gender, the assays still showed lower serum BDNF levels with higher BDI sum scores. Effects remained significant after correction for two main confounders (time of sampling and smoking), suggesting that they serve as molecular trait factors independent of lifestyle factors. Conclusions. Given the age sex interaction on serum BDNF levels and the known association between BDNF and gonadal hormones, research is warranted to delineate the effects of the latter interaction on the risk of psychiatric and neurodegenerative diseases.
C1 [Bus, Boudewijn A. A.; Tendolkar, Indira; Franke, Barbara; Voshaar, Richard C. Oude] Radboud Univ Nijmegen, Med Ctr, Dept Psychiat, NL-6525 GC Nijmegen, Netherlands.
   [Tendolkar, Indira; Buitelaar, Jan K.] Ctr Cognit Neuroimaging Nijmegen, Donders Inst Brain Cognit & Behav, Nijmegen, Netherlands.
   [Franke, Barbara] Radboud Univ Nijmegen, Med Ctr, Dept Human Genet, NL-6525 GC Nijmegen, Netherlands.
   [de Graaf, Jacqueline; Den Heijer, Martin] Radboud Univ Nijmegen, Med Ctr, Dept Gen Internal Med, NL-6525 GC Nijmegen, Netherlands.
   [Den Heijer, Martin] Radboud Univ Nijmegen, Med Ctr, Dept Epidemiol & Biostat, NL-6525 GC Nijmegen, Netherlands.
   [Voshaar, Richard C. Oude] Nijmegen Mental Hlth Ctr, Div Old Age Psychiat, Nijmegen, Netherlands.
C3 Radboud University Nijmegen; Radboud University Nijmegen; Radboud
   University Nijmegen; Radboud University Nijmegen; Radboud University
   Nijmegen
RP Bus, BAA (corresponding author), Radboud Univ Nijmegen, Med Ctr, Dept Psychiat, Reinier Postlaan 10, NL-6525 GC Nijmegen, Netherlands.
EM B.Bus@psy.umcn.nl
RI Tendolkar, I./O-5780-2019; Buitelaar, Jan/AAY-7522-2020; de Graaf,
   J./H-8038-2014; den Heijer, Martin/J-8036-2015; Franke,
   Barbara/D-4836-2009
OI Oude Voshaar, Richard/0000-0003-1501-4774; den Heijer,
   Martin/0000-0003-3620-5617; Franke, Barbara/0000-0003-4375-6572
FU NWO (Netherlands Organisation for Scientific Research) [90700231]
FX The BDNF measurements were financed by a Clinical Fellowship from the
   NWO (Netherlands Organisation for Scientific Research; project number
   90700231) awarded to Richard C. Oude Voshaar, MD, PhD. None of the
   authors has any conflict of interest to declare.
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NR 56
TC 92
Z9 93
U1 0
U2 11
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1562-2975
EI 1814-1412
J9 WORLD J BIOL PSYCHIA
JI World J. Biol. Psychiatry
PD JAN
PY 2012
VL 13
IS 1
BP 39
EP 47
DI 10.3109/15622975.2010.545187
PG 9
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 878ZF
UT WOS:000299296100006
PM 21247257
OA Green Published
DA 2025-06-11
ER

PT J
AU Fessel, J
AF Fessel, Jeffrey
TI Formulating Treatment to Cure Alzheimer's Dementia: Approach #2
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE Alzheimer's dementia; treat to cure; treat operative causal elements;
   treat individual patients; individualized treatments; personalized
   medicine
ID MILD COGNITIVE IMPAIRMENT; ENDOPLASMIC-RETICULUM STRESS; DISEASE MOUSE
   MODEL; ANTIHYPERTENSIVE DRUGS; INSULIN-RESISTANCE; GLUCOSE-TRANSPORT;
   INCIDENT DEMENTIA; PREDICTIVE ROLE; RISK-FACTORS; SLEEP
AB There are two generic approaches to curing any medical condition. The first one treats every patient for all the known possible causes that contribute to pathogenesis; the second one individualizes potentially curative therapy by only identifying in each separate patient the components of pathogenesis that are actually operative and treating those. This article adopts the second approach for formulating a cure for Alzheimer's dementia (AD). The components of AD's pathogenesis are, in alphabetical order, as follows: circadian rhythm disturbances, depression, diabetes and insulin resistance, dyslipidemia, hypertension, inflammation, metabolic syndrome, mitochondrial dysfunction, nutritional deficiencies, TGF-beta deficiency, underweight, vascular abnormalities, and Wnt/beta-catenin deficiency. For each component, data are described that show the degree to which its prevalence is higher in patients with mild cognitive impairment (MCI) who did not revert to having normal cognition than in those who did because the former group is the pool of patients in which future AD may develop. Only addressing the components that are present in a particular individual potentially is a curative strategy. Published data indicate that curative therapy requires the number of such components that are addressed to be >= 3. Although structural brain changes cannot be directly addressed, the impaired neural tracts result from many of the reversible causal elements, so correcting them will benefit these tracts.
C1 [Fessel, Jeffrey] Univ Calif San Francisco, Dept Med, 2069 Filbert St, San Francisco, CA 94123 USA.
C3 University of California System; University of California San Francisco
RP Fessel, J (corresponding author), Univ Calif San Francisco, Dept Med, 2069 Filbert St, San Francisco, CA 94123 USA.
EM jeffreyfessel@gmail.com
RI fessel, jeffrey/JDN-3283-2023
OI fessel, jeffrey/0000-0002-6772-3348
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NR 103
TC 1
Z9 1
U1 0
U2 4
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD MAR
PY 2024
VL 25
IS 6
AR 3524
DI 10.3390/ijms25063524
PG 18
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA MG8N2
UT WOS:001192564900001
PM 38542495
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Kerling, A
   von Bohlen, A
   Kück, M
   Tegtbur, U
   Grams, L
   Haufe, S
   Gützlaff, E
   Kahl, KG
AF Kerling, Arno
   von Bohlen, Anne
   Kueck, Momme
   Tegtbur, Uwe
   Grams, Lena
   Haufe, Sven
   Guetzlaff, Elke
   Kahl, Kai G.
TI Exercise therapy improves aerobic capacity of inpatients with major
   depressive disorder
SO BRAIN AND BEHAVIOR
LA English
DT Article
DE Aerobic capacity; major depression; maximum oxygen consumption; physical
   training; ventilatory anaerobic threshold
ID METABOLIC SYNDROME; PHYSICAL-EXERCISE; METAANALYSIS; FITNESS; BENEFITS
AB BackgroundUnipolar depression is one of the most common diseases worldwide and is associated with a higher cardiovascular risk partly due to reduced aerobic capacity.
   ObjectivesTherefore, the aim of our study was to examine whether a structured aerobic training program can improve aerobic capacity in inpatients with MDD (major depressive disorder).
   MethodsOverall, 25 patients (13 women, 12 men) diagnosed with MDD were included in the study. Parameters of aerobic capacity, such as maximum performance, maximum oxygen consumption, and VAT (ventilatory anaerobic threshold), were assessed on a bicycle ergometer before and 6weeks after a training period (three times per week for 45min on two endurance machines). In addition, a constant load test was carried out at 50% of the maximum performance prior to and after the training period. The performance data were compared with 25 healthy controls matched for sex, age, and body mass index before and after the training period.
   ResultsCompared to controls, patients with MDD had significantly lower aerobic capacity. After training, there was a significant improvement in their performance data. A significant difference remained only for VAT between patients with MDD and healthy controls.
   ConclusionWith regard to the coincidence of MDD with cardiovascular and cardiometabolic disorders, a structured supervised exercise program carried out during hospitalization is a useful supplement for patients with MDD.
C1 [Kerling, Arno; Kueck, Momme; Tegtbur, Uwe; Grams, Lena; Haufe, Sven; Guetzlaff, Elke] Hannover Med Sch, Inst Sports Med, Carl Neuberg Str 1, D-30625 Hannover, Germany.
   [von Bohlen, Anne; Kahl, Kai G.] Hannover Med Sch, Dept Psychiat Social Psychiat & Psychotherapy, Carl Neuberg Str 1, D-30625 Hannover, Germany.
   [Haufe, Sven] Hannover Med Sch, Inst Clin Pharmacol, Carl Neuberg Str 1, D-30625 Hannover, Germany.
C3 Hannover Medical School; Hannover Medical School; Hannover Medical
   School
RP Kerling, A (corresponding author), Hannover Med Sch, Inst Sports Med, Carl Neuberg Str 1, D-30625 Hannover, Germany.
EM Kerling.Arno@mh-hannover.de
RI Haufe, Sven/G-1944-2011
OI Haufe, Sven/0000-0002-5259-4352
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NR 31
TC 11
Z9 11
U1 1
U2 19
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 2162-3279
J9 BRAIN BEHAV
JI Brain Behav.
PD JUN
PY 2016
VL 6
IS 6
AR e00469
DI 10.1002/brb3.469
PG 6
WC Behavioral Sciences; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Behavioral Sciences; Neurosciences & Neurology
GA DQ2FR
UT WOS:000379018200006
PM 27134769
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Ramos, SR
   Reynolds, H
   Johnson, C
   Melkus, G
   Kershaw, T
   Thayer, JF
   Vorderstrasse, A
AF Ramos, S. Raquel
   Reynolds, Harmony
   Johnson, Constance
   Melkus, Gail
   Kershaw, Trace
   Thayer, Julian F.
   Vorderstrasse, Allison
TI Perceptions of HIV-Related Comorbidities and Usability of a Virtual
   Environment for Cardiovascular Disease Prevention Education in Sexual
   Minority Men With HIV: Formative Phases of a Pilot Randomized Controlled
   Trial
SO JOURNAL OF MEDICAL INTERNET RESEARCH
LA English
DT Article
DE virtual environment; digital health; gamification; eHealth; sexual
   minorities; cardiovascular disease; HIV; cardiometabolic risk; mental
   health; lesbian, gay, bisexual, transgender, and queer; LGBTQ health;
   HIV care; prevention; virtual; minority; men; Latin; Black; men who have
   sex with men; intervention; high blood pressure; myocardial infarction;
   preventive health screenings; gay; bisexual; patients; cancer
ID HUMAN-IMMUNODEFICIENCY-VIRUS; SAMPLE-SIZE; ALLOSTATIC LOAD; RISK; HEART;
   CARE; ADULTS; COLOR
AB Background: Sexual minority men with HIV are at an increased risk of cardiovascular disease (CVD) and have been underrepresented in behavioral research and clinical trials. Objective: This study aims to explore perceptions of HIV-related comorbidities and assess the interest in and usability of a virtual environment for CVD prevention education in Black and Latinx sexual minority men with HIV. Methods: This is a 3-phase pilot behavioral randomized controlled trial. We report on formative phases 1 and 2 that informed virtual environment content and features using qualitative interviews, usability testing, and beta testing with a total of 25 individuals. In phase 1, a total of 15 participants completed interviews exploring HIV-related illnesses of concern that would be used to tailor the virtual environment. In phase 2, usability testing and beta testing were conducted with 10 participants to assess interest, features, and content. Results: In phase 1, we found that CVD risk factors included high blood pressure, myocardial infarction, stroke, and diabetes. Cancer (prostate, colon, and others) was a common concern, as were mental health conditions. In phase 2, all participants completed the 12-item usability checklist with favorable feedback within 30 to 60 minutes. Beta-testing interviews suggested (1) mixed perceptions of health and HIV, (2) high risk for comorbid conditions, (3) virtual environment features were promising, and (4) the need for diverse avatar representations. Conclusions: We identified several comorbid conditions of concern, and findings carry significant implications for mitigating barriers to preventive health screenings, given the shared risk factors between HIV and related comorbidities. Highly rated aspects of the virtual environment were anonymity; meeting others with HIV who identify as gay or bisexual; validating lesbian, gay, bisexual, transgender, queer, and others (LGBTQ+) images and content; and accessibility to CVD prevention education. Critical end-user feedback from beta testing suggested more options for avatar customization in skin, hair, and body representation. Our next phase will test the virtual environment as a new approach to advancing cardiovascular health equity in ethnic and racial sexual minority men with HIV. Trial Registration: ClinicalTrials.gov NCT04061915; https://clinicaltrials.gov/study/NCT05242952 International Registered Report Identifier (IRRID): RR2-10.2196/38348
C1 [Ramos, S. Raquel] Yale Univ, Sch Nursing, 400 West Campus Dr, Orange, CT 06477 USA.
   [Ramos, S. Raquel; Kershaw, Trace] Yale Univ, Sch Publ Hlth Social & Behav Sci, New Haven, CT USA.
   [Ramos, S. Raquel; Kershaw, Trace] Yale Univ, Ctr Interdisciplinary Res AIDS, New Haven, NY USA.
   [Reynolds, Harmony] NYU, Grossman Sch Med, Cardiovasc Clin Res Ctr, Dept Med,Leon H Charney Div Cardiol, New York, NY USA.
   [Johnson, Constance] Univ Texas Hlth Sci Ctr Houston, Czik Sch Nursing, Houston, TX USA.
   [Johnson, Constance] Univ Texas Hlth Sci Ctr Houston, McWilliams Sch Biomed Informat, Houston, TX USA.
   [Melkus, Gail] NYU, Rory Myers Coll Nursing, New York, NY USA.
   [Thayer, Julian F.] Univ Calif Irvine, Sch Social Ecol, Psychol Sci, Irvine, CA USA.
   [Vorderstrasse, Allison] Univ Massachusetts Amherst, Elaine Marieb Coll Nursing, Amherst, MA USA.
C3 Yale University; Yale University; Yale University; New York University;
   University of Texas System; University of Texas Health Science Center
   Houston; University of Texas System; University of Texas Health Science
   Center Houston; New York University; University of California System;
   University of California Irvine; University of Massachusetts System;
   University of Massachusetts Amherst
RP Ramos, SR (corresponding author), Yale Univ, Sch Nursing, 400 West Campus Dr, Orange, CT 06477 USA.
EM raquel.ramos@yale.edu
RI Ramos, Raquel/O-6225-2017; Reynolds, Harmony/AAU-3154-2021
OI Ramos, S. Raquel/0000-0003-2403-7222; Johnson,
   Constance/0000-0003-3162-3932; Kershaw, Trace/0000-0002-3300-1355;
   Reynolds, Harmony/0000-0003-0284-0655; Melkus, Gail/0000-0002-5859-4118
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NR 58
TC 2
Z9 2
U1 1
U2 3
PU JMIR PUBLICATIONS, INC
PI TORONTO
PA 130 QUEENS QUAY East, Unit 1100, TORONTO, ON M5A 0P6, CANADA
SN 1438-8871
J9 J MED INTERNET RES
JI J. Med. Internet Res.
PD AUG 22
PY 2024
VL 26
AR e57351
DI 10.2196/57351
PG 15
WC Health Care Sciences & Services; Medical Informatics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Health Care Sciences & Services; Medical Informatics
GA F3H0L
UT WOS:001308755400003
PM 38924481
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Bikov, A
   Frent, S
   Pleava, R
   Kunos, L
   Bokhari, S
   Meszaros, M
   Mihaicuta, S
AF Bikov, Andras
   Frent, Stefan
   Pleava, Roxana
   Kunos, Laszlo
   Bokhari, Saba
   Meszaros, Martina
   Mihaicuta, Stefan
TI The Burden of Associated Comorbidities in Patients with Obstructive
   Sleep Apnea-Regional Differences in Two Central-Eastern European Sleep
   Centers
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Article
DE sleep apnea; comorbidities; cardiovascular disease; prevalence
ID UPDATE; PREVALENCE; DISEASE; HEALTH; RISK
AB Background: Obstructive sleep apnea (OSA) is usually associated with cardiovascular and cerebrovascular disease, metabolic syndrome and depression. Data on relevant OSA-associated comorbidities in Central-European populations are scarce. The aim of this study was to compare the prevalence of comorbidities in two OSA cohorts from Hungary and Romania. Methods: Data from 588 (282 from Hungary, 306 from Romania) untreated patients with OSA were retrospectively analyzed. The prevalence rates of hypertension, diabetes, dyslipidemia, allergic rhinitis, asthma, chronic obstructive pulmonary disease (COPD), osteoporosis, cerebrovascular and cardiovascular disease, arrhythmia and depression were compared between the two populations following adjustment for demographics, body mass index, smoking history, comorbidities and sleep parameters. Results: The prevalence rates of hypertension, arrhythmia, cerebrovascular and cardiovascular disease, diabetes and COPD in the whole study population were directly related to the severity of OSA. We found an inverse correlation between the prevalence of osteoporosis and OSA severity (all p < 0.05). Following adjustment, the prevalence of dyslipidemia was higher in the Hungarian cohort, whilst the prevalence of asthma, cardiovascular and cerebrovascular diseases was higher in the Romanian cohort (all p < 0.05). Conclusions: There was no difference in the prevalence rate of most comorbidities in patients with OSA from the two cohorts, except for dyslipidemia, asthma, cardiovascular and cerebrovascular disease.
C1 [Bikov, Andras; Kunos, Laszlo; Meszaros, Martina] Semmelweis Univ, Dept Pulmonol, H-1085 Budapest, Hungary.
   [Bikov, Andras; Bokhari, Saba] Manchester Univ NHS Fdn Trust, Wythenshawe Hosp, North West Lung Ctr, Manchester M23 9LT, Lancs, England.
   [Bikov, Andras] Univ Manchester, Div Infect Immun & Resp Med, Manchester M23 9LT, Lancs, England.
   [Frent, Stefan; Mihaicuta, Stefan] Univ Med & Pharm, Dept Pulmonol, Timisoara 300041, Romania.
   [Pleava, Roxana] Univ Med & Pharm, Dept Cardiol, Timisoara 300041, Romania.
C3 Semmelweis University; Manchester University NHS Foundation Trust;
   Wythenshawe Hospital NHS Foundation Trust; Wythenshawe Hospital;
   University of Manchester; Victor Babes University of Medicine &
   Pharmacy, Timisoara; Victor Babes University of Medicine & Pharmacy,
   Timisoara
RP Frent, S (corresponding author), Univ Med & Pharm, Dept Pulmonol, Timisoara 300041, Romania.
EM andras.bikov@gmail.com; frentz.stefan@umft.ro; roxana.pleava@gmail.com;
   laszlo.kunos@gmail.com; saba.bokhari1@mft.nhs.uk;
   martina.meszaros1015@gmail.com; stefan.mihaicuta@umft.ro
RI Bikov, Andras/I-1719-2019; Pleava, Roxana/ABD-5453-2020; Frent,
   Stefan/GZG-5377-2022; Mihaicuta, Stefan/AAD-4531-2019
OI Bikov, Andras/0000-0002-8983-740X; Frent, Stefan/0000-0002-7469-6755;
   MIHAICUTA, STEFAN/0000-0001-8897-8342
FU Hungarian Thoracic Society; Semmelweis University; "Victor Babes"
   University of Medicine and Pharmacy, Timisoara, Romania
FX The studies were supported by the Hungarian Thoracic Society (grants to
   A.B. and M.M.) and Semmelweis University (grant to L.K.), and "Victor
   Babes" University of Medicine and Pharmacy, Timisoara, Romania.
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NR 36
TC 16
Z9 16
U1 0
U2 6
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD NOV
PY 2020
VL 9
IS 11
AR 3583
DI 10.3390/jcm9113583
PG 10
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA OY1NN
UT WOS:000594019800001
PM 33172084
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Torre-Villalvazo, I
   Bunt, AE
   Alemán, G
   Marquez-Mota, CC
   Diaz-Villaseñor, A
   Noriega, LG
   Estrada, I
   Figueroa-Juárez, E
   Tovar-Palacio, C
   Rodriguez-López, LA
   López-Romero, P
   Torres, N
   Tovar, AR
AF Torre-Villalvazo, Ivan
   Bunt, Ana E.
   Aleman, Gabriela
   Marquez-Mota, Claudia C.
   Diaz-Villasenor, Andrea
   Noriega, Lilia G.
   Estrada, Isabela
   Figueroa-Juarez, Elizabeth
   Tovar-Palacio, Claudia
   Rodriguez-Lopez, Leonardo A.
   Lopez-Romero, Patricia
   Torres, Nimbe
   Tovar, Armando R.
TI Adiponectin synthesis and secretion by subcutaneous adipose tissue is
   impaired during obesity by endoplasmic reticulum stress
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Article
DE adiponectin; endoplasmic reticulum stress; lipolysis; obesity;
   subcutaneous adipose tissue; tunicamycin; visceral adipose tissue
ID ER STRESS; ALKALINE-PHOSPHATASE; METABOLIC SYNDROME; INSULIN;
   EXPRESSION; GLUCOSE; EXPANDABILITY; PIOGLITAZONE; LIPOTOXICITY;
   ASSOCIATION
AB Subcutaneous (SAT) and visceral (VAT) adipose tissues stores excess energy as triglycerides and synthesize adiponectin to prevent ectopic lipid accumulation and lipotoxicity. During obesity, an impairment in the capacity of SAT to store triglycerides and synthesize adiponectin is associated with increased free fatty acids (FFA) release, leading to VAT hypertrophy and hepatic and skeletal muscle lipotoxicity. Endoplasmic reticulum (ER) stress and the unfolded protein response (UPR) may be involved in SAT dysfunction during obesity. The objectives of this study were to assess UPR activation and adiponectin synthesis in: 1) SAT and VAT from mice exposed to acute pharmacologic or chronic obesity-induced ER stress and in 2) cultured mice primary mature adipocytes or adipocytes differentiated in vitro from SAT and VAT exposed to tunicamycin or thapsigargin. Mice fed a high-fat diet developed obesity, increased FFA and lower circulating adiponectin in association with lower adiponectin synthesis and increased UPR markers in SAT. Mice subjected to acute ER stress by pioglitazone administration and a low-dose tunicamycin injection presented a maladaptive UPR activation in SAT along with reduced adiponectin synthesis and secretion and increased lipolysis with respect to VAT, associated with lipid accumulation in skeletal muscle and liver. Primary adipocytes and adipocytes differentiated from SAT exposed to pharmacologic ER stress also developed maladaptive UPR, along with reduced adiponectin synthesis and increased lipolysis with respect to those from VAT. Our results indicate that compared to VAT, SAT is more susceptible to ER stress, leading to increased lipolysis and reduced adiponectin synthesis and secretion.
C1 [Torre-Villalvazo, Ivan; Bunt, Ana E.; Aleman, Gabriela; Marquez-Mota, Claudia C.; Diaz-Villasenor, Andrea; Noriega, Lilia G.; Estrada, Isabela; Rodriguez-Lopez, Leonardo A.; Lopez-Romero, Patricia; Torres, Nimbe; Tovar, Armando R.] Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Fisiol Nutr, Av Vasco de Quiroga 15, Mexico City 14080, Cdmx, Mexico.
   [Marquez-Mota, Claudia C.] FMVZ UNAM, Dept Nutr Anim & Bioquim, Mexico City, DF, Mexico.
   [Diaz-Villasenor, Andrea] Univ Nacl Autonoma Mexico, IIB, Mexico City, DF, Mexico.
   [Figueroa-Juarez, Elizabeth; Tovar-Palacio, Claudia] Inst Nacl Ciencias Med & Nutr Salvador, Dept Nefrol & Metab Mineral, Mexico City, DF, Mexico.
C3 Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran -
   Mexico; Universidad Nacional Autonoma de Mexico; Universidad Nacional
   Autonoma de Mexico
RP Torre-Villalvazo, I; Tovar, AR (corresponding author), Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Fisiol Nutr, Av Vasco de Quiroga 15, Mexico City 14080, Cdmx, Mexico.
EM ivan.inn@gmail.com; tovar.ar@gmail.com
RI ALEMAN, GABRIELA/AAB-6484-2020; Tovar-Palacio, Claudia/AAE-4572-2022;
   Noriega, Lilia/ABF-4876-2020; Márquez - Mota, Claudia/KRP-6516-2024;
   Torres, Nimbe/AAI-4340-2020; Torre-Villalvazo, Ivan/M-2497-2014
OI Figueroa-Juarez, Elizabeth/0000-0002-5634-7682; Aleman,
   Gabriela/0000-0003-0755-2302; Tovar-Palacio,
   Claudia/0000-0001-7965-6421; Noriega, Lilia G./0000-0003-2156-9872;
   Rodriguez Lopez, Leonardo Alejandro/0000-0001-8173-9314;
   Torre-Villalvazo, Ivan/0000-0001-7412-1153; Marquez Mota, Claudia
   Cecilia/0000-0002-4311-381X; Diaz-Villasenor, Andrea/0000-0003-1222-2615
FU Consejo Nacional de Ciencia y Tecnologia [84754]
FX Consejo Nacional de Ciencia y Tecnologia, Grant number: 84754
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NR 54
TC 47
Z9 54
U1 1
U2 26
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0730-2312
EI 1097-4644
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PD JUL
PY 2018
VL 119
IS 7
BP 5970
EP 5984
DI 10.1002/jcb.26794
PG 15
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA GI1JU
UT WOS:000434127400086
PM 29575057
DA 2025-06-11
ER

PT J
AU Toklu, HZ
   Scarpace, PJ
   Sakarya, Y
   Kirichenko, N
   Matheny, M
   Bruce, EB
   Carter, CS
   Morgan, D
   Tümer, N
AF Toklu, Hale Z.
   Scarpace, Philip J.
   Sakarya, Yasemin
   Kirichenko, Nataliya
   Matheny, Michael
   Bruce, Erin B.
   Carter, Christy S.
   Morgan, Drake
   Tumer, Nihal
TI Intracerebroventricular tempol administration in older rats reduces
   oxidative stress in the hypothalamus but does not change STAT3
   signalling or SIRT1/AMPK pathway
SO APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
LA English
DT Article
DE tempol; intracerebroventricular (icv); brain; hypothalamus; aging;
   obesity; SIRT1; AMPK; leptin; p53; FOXO; STAT3; oxidative stress
ID ANGIOTENSIN-II; METABOLIC SYNDROME; RODENT MODEL; BRAIN; LEPTIN;
   ACTIVATION; EXCITATION; AGE
AB Hypothalamic inflammation and increased oxidative stress are believed to be mechanisms that contribute to obesity. 4-Hydroxy-2,2,6,6-tetramethylpiperidine-N-oxyl (tempol), a free radical scavenger, has been shown to reduce inflammation and oxidative stress. We hypothesized that brain infusion of tempol would reduce oxidative stress, and thus would reduce food intake and body weight and improve body composition in rats with age-related obesity and known elevated oxidative stress. Furthermore, we predicted an associated increase in markers of leptin signalling, including the silent mating type information regulator 2 homolog 1 (SIRT1)/5' AMP-activated protein kinase (AMPK) pathway and the signal transducer and activator of transcription 3 (STAT3) pathway. For this purpose, osmotic minipumps were placed in the intracerebroventricular region of young (3 months) and aged (23 months) male Fischer 344 x Brown Norway rats for the continuous infusion of tempol or vehicle for 2 weeks. Tempol significantly decreased (p < 0.01) nicotinamide adenine dinucleotide phosphate oxidase activity in the hypothalamus but failed to reduce food intake or weight gain and did not alter body composition. SIRT1 activity and Acetyl p53 were decreased and phosphorylation of AMPK was increased with age, but they were unchanged with tempol. Basal phosphorylation of STAT3 was unchanged with age or tempol. These results indicate that tempol decreases oxidative stress but fails to alter feeding behaviour, body weight, or body composition. Moreover, tempol does not modulate the SIRT1/AMPK/p53 pathway and does not change leptin signalling. Thus, a reduction in hypothalamic oxidative stress is not sufficient to reverse age-related obesity.
C1 [Toklu, Hale Z.; Kirichenko, Nataliya; Tumer, Nihal] Malcolm Randall Vet Affairs Med Ctr, Geriatr Res Educ & Clin Ctr, Gainesville, FL 32608 USA.
   [Toklu, Hale Z.; Scarpace, Philip J.; Sakarya, Yasemin; Kirichenko, Nataliya; Matheny, Michael; Bruce, Erin B.; Tumer, Nihal] Univ Florida, Dept Pharmacol & Therapeut, Gainesville, FL 32610 USA.
   [Carter, Christy S.] Univ Florida, Dept Aging & Geriatr Res, Gainesville, FL 32610 USA.
   [Morgan, Drake] Univ Florida, Dept Psychiat, Gainesville, FL 32610 USA.
C3 Geriatric Research Education & Clinical Center; State University System
   of Florida; University of Florida; State University System of Florida;
   University of Florida; State University System of Florida; University of
   Florida
RP Toklu, HZ; Tümer, N (corresponding author), Malcolm Randall Vet Affairs Med Ctr, Geriatr Res Educ & Clin Ctr, Gainesville, FL 32608 USA.; Toklu, HZ; Tümer, N (corresponding author), Univ Florida, Dept Pharmacol & Therapeut, Gainesville, FL 32610 USA.
EM haletoklu@yahoo.com; ntumer@ufl.edu
RI Morgan, Drake/F-6664-2012; Bruce, Erin/MTG-5640-2025; Toklu,
   Hale/AAR-2330-2020
OI Sakarya, Yasemin/0009-0009-5927-0199; Toklu, Hale/0000-0002-9797-3591
FU National Institutes of Health [DK 091710]; North Florida/South Georgia
   Veterans Health System, Research/GRECC, Gainesville, Florida, USA
FX This work was supported by National Institutes of Health Grant DK 091710
   and by the North Florida/South Georgia Veterans Health System,
   Research/GRECC, Gainesville, Florida, USA.
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NR 35
TC 8
Z9 8
U1 0
U2 9
PU CANADIAN SCIENCE PUBLISHING
PI OTTAWA
PA 123 Slater Street, Suite 610, OTTAWA, ON K1P 5H2, CANADA
SN 1715-5312
EI 1715-5320
J9 APPL PHYSIOL NUTR ME
JI Appl. Physiol. Nutr. Metab.
PD JAN
PY 2017
VL 42
IS 1
BP 59
EP 67
DI 10.1139/apnm-2016-0067
PG 9
WC Nutrition & Dietetics; Physiology; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics; Physiology; Sport Sciences
GA EI1OC
UT WOS:000392245900009
PM 28006433
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Wu, B
   Fukuo, K
   Suzuki, K
   Yoshino, G
   Kazumi, T
AF Wu, Bin
   Fukuo, Keisuke
   Suzuki, Kazuhisa
   Yoshino, Gen
   Kazumi, Tsutomu
TI Relationships of Systemic Oxidative Stress to Body Fat Distribution,
   Adipokines and Inflammatory Markers in Healthy Middle-aged Women
SO ENDOCRINE JOURNAL
LA English
DT Article
DE Oxidative stress; Body fat distribution; Adipokines
ID ADIPOSE-TISSUE ACCUMULATION; X-RAY ABSORPTIOMETRY; INSULIN-RESISTANCE;
   CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; LIPID-PEROXIDATION;
   LIPOPROTEIN-LIPASE; VISCERAL FAT; OBESITY; RISK
AB Obesity and systemic oxidative stress are closely related. However data concerning the relationships between oxidative stress and body fat mass distribution are sparse. Anthropometric and metabolic profile was evaluated in 148 clinically healthy middle-aged women to assess the correlations between oxidative stress, fat mass distribution, adipokines, and inflammatory markers. Systemic oxidative stress was assessed by urinary creatinine-indexed 8-epi-prostaglandin F-(2 alpha) (8-epi-PGF(2 alpha)). Body fat mass distribution was examined by dual-energy X-ray absorptiometry (DXA). Lipid profile, adipokines and inflammatory markers including leptin, adiponectin, high sensitive C-reactive protein (hsCRP), plasminogen activator inhibitor-1 (PAI-1), tumor necrosis factor-alpha (TNF-alpha) were determined. We found body mass index (BMI), waist circumference (WC), both central and peripheral DXA-derived regional Fat mass (FM) accumulations were positively correlated with 8-epi-PGF(2 alpha). Leptin, hsCRP and PAI-1 also positively associated with 8-epi-PGF(2 alpha). After adjustment for BMI and WC, lower-body FM, total FM and PAI-1 retained significant association with 8-epi-PGF(2 alpha). Mutliple linear regression analyses indicated lower-body FM and PAI-1 were the two important predicators of 8-epi-PGF(2 alpha). These results suggest that DXA-derived regional FM indices, especially low extremity adiposity, are more closely associated with systemic oxidative stress than indirect anthropometric indices. Positive associations between 8-epi-PGF(2 alpha) and PAI-1, hsCRP, leptin support the notion that oxidative-stress-induced dysregulation of inflammation and adipokines may mediate the obesity-related metabolic derangement.
C1 [Wu, Bin; Fukuo, Keisuke; Suzuki, Kazuhisa; Kazumi, Tsutomu] Mukogawa Womens Univ, Open Res Ctr Studying Lifestyle Related Dis, Nishinomiya, Hyogo 6638558, Japan.
   [Fukuo, Keisuke; Suzuki, Kazuhisa; Kazumi, Tsutomu] Mukogawa Womens Univ, Dept Food Sci & Nutr, Sch Human Environm Sci, Nishinomiya, Hyogo 6638558, Japan.
   [Yoshino, Gen] Toho Univ, Dept Endocrinol & Diabet, Omori Med Ctr, Omori Ku, Tokyo, Japan.
C3 Mukogawa Women's University; Mukogawa Women's University; Toho
   University
RP Wu, B (corresponding author), Mukogawa Womens Univ, Open Res Ctr Studying Lifestyle Related Dis, 6-46 Ikebiraki Cho, Nishinomiya, Hyogo 6638558, Japan.
EM wu.bin@gmx.com
RI Wu, Bin/R-7389-2019
OI Wu, Bin/0000-0002-0399-0762
FU Open Research Center Project for Private University; Matching Fund
   Subsidy for Private Universities; Ministries of Education, Culture,
   Sports, Science and Technology, Japan
FX This study was supported by Open Research Center Project for Private
   University: Matching Fund Subsidy for Private Universities, The
   Ministries of Education, Culture, Sports, Science and Technology, Japan.
   We are indebted to all the participants for their dedicated and
   conscientious collaboration.
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NR 51
TC 45
Z9 47
U1 0
U2 4
PU JAPAN ENDOCRINE SOC
PI KYOTO
PA 75  YANAGINOBANBA NISHIIRU-MASUYA-CHO, SANJOU-DORI, NAKAGYOU-KU, KYOTO,
   604-8111, JAPAN
SN 0918-8959
EI 1348-4540
J9 ENDOCR J
JI Endocr. J.
PD SEP
PY 2009
VL 56
IS 6
BP 773
EP 782
DI 10.1507/endocrj.K08E-332
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 512OT
UT WOS:000271260300008
PM 19506322
OA Bronze
DA 2025-06-11
ER

PT J
AU Liu, GL
   Zhang, YM
   Dai, DZ
   Ding, MJ
   Cong, XD
   Dai, Y
AF Liu, Gui-Lai
   Zhang, Yu-Mao
   Dai, De-Zai
   Ding, Ming-Jian
   Cong, Xiao-Dong
   Dai, Yin
TI Male hypogonadism induced by high fat diet and low dose streptozotocin
   is mediated by activated endoplasmic reticulum stress and IκBβ and
   attenuated by argirein and valsartan
SO EUROPEAN JOURNAL OF PHARMACOLOGY
LA English
DT Article
DE Type 2 diabetes; Testopathy; Argirein; ER stress; I kappa B beta;
   p-Akt/Akt
ID STRONTIUM FRUCTOSE 1,6-DIPHOSPHATE; RECEPTOR ANTAGONIST CPU0213;
   METABOLIC SYNDROME; OXIDATIVE STRESS; ER STRESS; INSULIN-RESISTANCE;
   PPAR-ALPHA; MATRIX-METALLOPROTEINASE; ENDOTHELIN RECEPTOR; INDUCED
   OBESITY
AB Male hypogonadism is frequently accompanied with type 2 diabetes due to testicular dysfunction, but the origin of the pathogenesis is not known. We measured whether pro-inflammatory factors including endoplasmic reticulum (ER) stress chaperones and inhibitory kappa B beta (I kappa B beta) contribute to testis damage in type 2 diabetic rats produced by a high-fat diet (HFD) and low dose streptozotocin (STZ). We determined whether these can be attenuated by the anti-inflammatory activity of argirein a derivative of rhein as compared to valsartan. Reduced testosterone and LH (luteinizing hormone) levels in serum were significant in association with a decrease in the levels of mRNA and steroidogenic acute regulatory protein (StAR), insulin receptor substrate (IRS-1), activated I kappa B beta and ER stress chaperone C/EBP homologous protein (CHOP) in the diabetic testis and sperm count, motility and sexual behaviors were reduced in vivo. Additionally, Leydig cells cultured with high glucose showed upregulated I kappa B beta, ER stress sensor PERK (PKR-like ER kinase) and p-Akt/Akt in vitro. These changes may be due to a component of inflammation linked to activated NADPH oxidase and were significantly alleviated by either argirein or valsartan. In conclusion, diabetic testopathy induced by a HFD and low STZ is characterized by an entity of inflammation and is alleviated by argirein and valsartan through normalizing activated I kappa B beta and ER stress. (C) 2013 Elsevier B.V. All rights reserved.
C1 [Liu, Gui-Lai; Zhang, Yu-Mao; Dai, De-Zai; Ding, Ming-Jian; Dai, Yin] China Pharmaceut Univ, Res Div Pharmacol, Nanjing 210009, Jiangsu, Peoples R China.
   [Ding, Ming-Jian; Cong, Xiao-Dong] Zhejiang Chinese Med Univ, Hangzhou 310053, Zhejiang, Peoples R China.
C3 China Pharmaceutical University; Zhejiang Chinese Medical University
RP Dai, DZ (corresponding author), China Pharmaceut Univ, Res Div Pharmacol, Nanjing 210009, Jiangsu, Peoples R China.
EM dezaidai@vip.sina.com
RI Ding, Mingjian/MTE-1820-2025
FU National Nature Science Foundation of China [81070145]
FX This work was supported by the National Nature Science Foundation of
   China No: 81070145. Many thanks to Prof. David Triggle from the State
   University of New York for his kind assistance to edit the English
   writing style of the MS.
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NR 61
TC 25
Z9 29
U1 0
U2 33
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0014-2999
EI 1879-0712
J9 EUR J PHARMACOL
JI Eur. J. Pharmacol.
PD AUG 5
PY 2013
VL 713
IS 1-3
BP 78
EP 88
DI 10.1016/j.ejphar.2013.04.030
PG 11
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 171CY
UT WOS:000320903900012
PM 23665494
DA 2025-06-11
ER

PT J
AU Yoshida, S
   Hashimoto, T
   Kihara, M
   Imai, N
   Yasuzaki, H
   Nomura, K
   Kiuchi, Y
   Tamura, K
   Ishigami, T
   Hirawa, N
   Toya, Y
   Kitamura, H
   Umemura, S
AF Yoshida, Shin-ichiro
   Hashimoto, Tatsuo
   Kihara, Minoru
   Imai, Nozomi
   Yasuzaki, Hiroaki
   Nomura, Kouichirou
   Kiuchi, Yoshihiro
   Tamura, Kouichi
   Ishigami, Tomoaki
   Hirawa, Nobuhito
   Toya, Yoshiyuki
   Kitamura, Hitoshi
   Umemura, Satoshi
TI Urinary Oxidative Stress Markers Closely Reflect the Efficacy of
   Candesartan Treatment for Diabetic Nephropathy
SO NEPHRON EXPERIMENTAL NEPHROLOGY
LA English
DT Article
DE Diabetic nephropathy; Mouse models; Oxidative stress; Angiotensin II
   receptor blocker; Therapeutic markers; Urinary albumin excretion;
   Glomeruli
ID II TYPE-1 RECEPTOR; GENE-KNOCKOUT MICE; RENIN-ANGIOTENSIN SYSTEM;
   NITRIC-OXIDE SYNTHASE; KK/TA MICE; JUXTAGLOMERULAR APPARATUS; INCREASED
   EXPRESSION; METABOLIC SYNDROME; KIDNEY-DISEASE; END-PRODUCTS
AB Backgrounds/Aims: It has been reported that urinary oxidative stress markers are higher in diabetic patients with proteinuria. We performed the present study to elucidate the relationship between urinary excretion of oxidative stress markers, albumin excretion, and histological changes, and to confirm the potential utility of oxidative stress markers for clinical treatment. Methods: Diabetic db/db mice or nondiabetic db/m mice were administered candesartan (10 mg/kg/day) or hydralazine (50 mg/kg/day) for 18 weeks. Results: Thirty-week-old male db/db mice treated with control vehicle revealed elevated urinary excretion and immunohistological levels of 8-hydroxydeoxyguanosine in glomeruli when compared to db/m mice. Treatment with candesartan, but not hydralazine, reduced these values to levels in db/m mice. Increased mesangial expansion, urinary excretion of albumin and 8-isoprostane, and glomerular immunohistological levels of nitrotyrosine in db/db mice were also decreased markedly by candesartan but not hydralazine. Interestingly, correlations between levels of albumin and oxidative stress markers in urine were very high, even when groups undergoing long-term (44 weeks) treatment were included (correlation coefficient 0.767 with respect to 8-hydroxydeoxyguanosine, 0.888 with respect to 8-isoprostane). Conclusion: It is anticipated that urinary concentrations of oxidative stress markers will be direct barometers of glomerulus-derived oxidative stress and glomerular injury in diabetic nephropathy. Copyright (c) 2009 S. Karger AG, Basel
C1 [Hashimoto, Tatsuo] Yokohama City Univ, Grad Sch Med, Dept Med Sci & Cardiorenal Med, Kanazawa Ku, Yokohama, Kanagawa 2360004, Japan.
   [Kiuchi, Yoshihiro] Yokohama City Univ, Grad Sch Med, Lab Anim Facil, Yokohama, Kanagawa 2360004, Japan.
   [Kitamura, Hitoshi] Yokohama City Univ, Grad Sch Med, Dept Cellular Pathobiol, Yokohama, Kanagawa 2360004, Japan.
   Yokohama City Univ, Sch Med, Yokohama, Kanagawa 232, Japan.
C3 Yokohama City University; Yokohama City University; Yokohama City
   University; Yokohama City University
RP Hashimoto, T (corresponding author), Yokohama City Univ, Grad Sch Med, Dept Med Sci & Cardiorenal Med, Kanazawa Ku, Yokohama, Kanagawa 2360004, Japan.
EM tatuhashi@hotmail.com
FU Japan Society for the Promotion of Science Grant (JSPS) [16590892];
   Yokohama Foundation for the Advancement of Medical Science;
   Grants-in-Aid for Scientific Research [16590892] Funding Source: KAKEN
FX This study was supported by grants from the 21st Century COE Program,
   from the Japan Society for the Promotion of Science Grant (JSPS), a
   grant-in-aid for Scientific Research from the JSPS (16590892), and from
   the Yokohama Foundation for the Advancement of Medical Science.
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NR 34
TC 14
Z9 18
U1 0
U2 2
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1660-2129
J9 NEPHRON EXP NEPHROL
JI Nephron Exp. Nephrol
PY 2009
VL 111
IS 1
BP E20
EP E30
DI 10.1159/000178764
PG 11
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 385RG
UT WOS:000261830700003
PM 19052474
DA 2025-06-11
ER

PT J
AU Sánchez-Sarasúa, S
   Fernández-Pérez, I
   Espinosa-Fernández, V
   Sánchez-Pérez, AM
   Ledesma, JC
AF Sanchez-Sarasua, Sandra
   Fernandez-Perez, Ivan
   Espinosa-Fernandez, Veronica
   Maria Sanchez-Perez, Ana
   Carlos Ledesma, Juan
TI Can We Treat Neuroinflammation in Alzheimer's Disease?
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE Alzheimer&#8217; s disease; neuroinflammation; insulin resistance;
   nutraceuticals; endocannabinoid system; gut microbiota
ID GUT-BRAIN AXIS; PLACEBO-CONTROLLED TRIAL; DOUBLE-BLIND;
   INSULIN-RESISTANCE; COGNITIVE FUNCTION; MEMORY DEFICITS; MEDICINAL
   APPLICATIONS; MICROGLIAL CELLS; MICROBIOTA; INFLAMMATION
AB Alzheimer's disease (AD), considered the most common type of dementia, is characterized by a progressive loss of memory, visuospatial, language and complex cognitive abilities. In addition, patients often show comorbid depression and aggressiveness. Aging is the major factor contributing to AD; however, the initial cause that triggers the disease is yet unknown. Scientific evidence demonstrates that AD, especially the late onset of AD, is not the result of a single event, but rather it appears because of a combination of risk elements with the lack of protective ones. A major risk factor underlying the disease is neuroinflammation, which can be activated by different situations, including chronic pathogenic infections, prolonged stress and metabolic syndrome. Consequently, many therapeutic strategies against AD have been designed to reduce neuro-inflammation, with very promising results improving cognitive function in preclinical models of the disease. The literature is massive; thus, in this review we will revise the translational evidence of these early strategies focusing in anti-diabetic and anti-inflammatory molecules and discuss their therapeutic application in humans. Furthermore, we review the preclinical and clinical data of nutraceutical application against AD symptoms. Finally, we introduce new players underlying neuroinflammation in AD: the activity of the endocannabinoid system and the intestinal microbiota as neuroprotectors. This review highlights the importance of a broad multimodal approach to treat successfully the neuroinflammation underlying AD.
C1 [Sanchez-Sarasua, Sandra; Fernandez-Perez, Ivan; Espinosa-Fernandez, Veronica; Maria Sanchez-Perez, Ana; Carlos Ledesma, Juan] Univ Jaume 1, Hlth Sci Fac, Dept Med, Neurobiotechnol Grp, Castellon de La Plana 12071, Spain.
C3 Universitat Jaume I
RP Sánchez-Pérez, AM; Ledesma, JC (corresponding author), Univ Jaume 1, Hlth Sci Fac, Dept Med, Neurobiotechnol Grp, Castellon de La Plana 12071, Spain.
EM sarasuad@uji.es; ivfernan@uji.es; veronica.espinosa@uji.es;
   sanchean@med.uji.es; ledesma@uji.es
RI Ledesma, Juan/AAA-2722-2019; Sanchez-Perez, Ana Maria/AAB-4454-2019;
   Sanchez-Sarasua, Sandra/JLL-2630-2023
OI Sanchez-Perez, Ana Maria/0000-0002-5811-0005; Sanchez-Sarasua,
   Sandra/0000-0002-9759-1665; Espinosa-Fernandez,
   Veronica/0000-0003-3818-2754; Ledesma, Juan Carlos/0000-0001-6372-2842
FU Plan Propi [UJI-B2018-01]; Conselleria de Innovacion, Universidades,
   Ciencia y Sociedad Digital [ACIF/2016/250]
FX This work has been funded by Plan Propi UJI-B2018-01 to AMSP.
   Predoctoral fellowship from Conselleria de Innovacion, Universidades,
   Ciencia y Sociedad Digital ACIF/2016/250 to SSS.
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NR 158
TC 45
Z9 47
U1 2
U2 21
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD NOV
PY 2020
VL 21
IS 22
AR 8751
DI 10.3390/ijms21228751
PG 23
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA OZ4BX
UT WOS:000594874700001
PM 33228179
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Jaggers, JR
AF Jaggers, Jason R.
TI Exercise and Positive Living in Human Immunodeficiency Virus/AIDS
SO NURSING CLINICS OF NORTH AMERICA
LA English
DT Article
DE Physical activity; Fitness; Exercise; Stress; HIV
ID QUALITY-OF-LIFE; CARDIORESPIRATORY FITNESS; METABOLIC SYNDROME;
   PHYSICAL-ACTIVITY; BODY-COMPOSITION; CARDIOVASCULAR-DISEASE; INFECTED
   PATIENTS; AEROBIC EXERCISE; ALL-CAUSE; INDEXES
AB Evidence would suggest that regardless of disease status, people living with human immunodeficiency virus (HIV)/AIDS can obtain similar health benefits from routine physical activity reported within general populations. Research has shown significant improvements among psychological and physiologic variables within the first 5 to 6 weeks of beginning a routine physical activity program. Daily activity has shown promising results in other clinical populations, but there is still a paucity of research that limits evidence among the HIV population. Additional research is needed to examine the long-term benefits of physical activity and to discover more practical ways to achieve this lifestyle change.
C1 [Jaggers, Jason R.] Univ Louisville, Dept Hlth & Sport Sci, 2100 South Floyd St SAC East 104, Louisville, KY 40208 USA.
C3 University of Louisville
RP Jaggers, JR (corresponding author), Univ Louisville, Dept Hlth & Sport Sci, 2100 South Floyd St SAC East 104, Louisville, KY 40208 USA.
EM Jason.jaggers@louisville.edu
RI Jaggers, Jason/ABB-4670-2021
OI Jaggers, Jason/0000-0002-2567-615X
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NR 41
TC 6
Z9 8
U1 0
U2 5
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0029-6465
EI 1558-1357
J9 NURS CLIN N AM
JI Nurs. Clin. North Am.
PD MAR
PY 2018
VL 53
IS 1
BP 1
EP +
DI 10.1016/j.cnur.2017.09.003
PG 12
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA FX6VO
UT WOS:000426225600002
PM 29362054
DA 2025-06-11
ER

PT J
AU Zambrano, E
   Nathanielsz, PW
AF Zambrano, Elena
   Nathanielsz, Peter W.
TI Mechanisms by which maternal obesity programs offspring for obesity:
   evidence from animal studies
SO NUTRITION REVIEWS
LA English
DT Review
DE altricial mammalian species; maternal obesity; offspring phenotype;
   offspring programming mechanisms; precocial mammalian species
ID HIGH-FAT DIET; PITUITARY-ADRENAL FUNCTION; FETAL THYROID AXIS;
   PHOSPHOENOLPYRUVATE CARBOXYKINASE; INSULIN-RESISTANCE; METABOLIC
   SYNDROME; REPRODUCTIVE AGE; BLOOD-PRESSURE; PLASMA LEPTIN; BIRTH-WEIGHT
AB Maternal obesity can profoundly affect offspring phenotype and predisposition to obesity and metabolic disease. Carefully controlled studies in precocial and altricial mammalian species provide insights into the involved mechanisms. These include programming of hypothalamic appetite-regulating centers to increase orexigenic relative to anorexigenic drive; increasing maternal, fetal, and offspring adrenal and peripheral tissue glucocorticoid production; and increasing maternal oxidative stress. Outcomes often show offspring sex differences that may play a role in the differential susceptibility of males and females to later-life obesity and other related metabolic diseases. (C) 2013 International Life Sciences Institute
C1 [Zambrano, Elena] Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Reprod Biol, Salvador Zubiran 14000, Mexico.
   [Nathanielsz, Peter W.] Univ Texas Hlth Sci Ctr San Antonio, Dept Obstet & Gynecol, Ctr Pregnancy & Newborn Res, San Antonio, TX 78229 USA.
C3 Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran -
   Mexico; University of Texas System; University of Texas Health Science
   Center at San Antonio
RP Zambrano, E (corresponding author), Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Reprod Biol, Salvador Zubiran 14000, Mexico.
EM zamgon@unam.mx
OI Zambrano, Elena/0000-0002-0362-9117; Nathanielsz,
   Peter/0000-0001-8410-6280
FU CONACyT (Consejo Nacional de Ciencia y Tecnologia), Mexico [155166];
   Sociedad Mexicana de Nutricion y Endocrinologia; National Institute of
   Child Health and Human Development [HD 21350]
FX This work was partially supported by CONACyT (Consejo Nacional de
   Ciencia y Tecnologia) 155166, Mexico, Sociedad Mexicana de Nutricion y
   Endocrinologia and HD 21350 from the National Institute of Child Health
   and Human Development.
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NR 104
TC 89
Z9 95
U1 1
U2 22
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0029-6643
EI 1753-4887
J9 NUTR REV
JI Nutr. Rev.
PD OCT
PY 2013
VL 71
SU 1
SI SI
BP S42
EP S54
DI 10.1111/nure.12068
PG 13
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 237HF
UT WOS:000325858900008
PM 24147924
OA Bronze
DA 2025-06-11
ER

PT J
AU Reichel, M
   Rhein, C
   Hofmann, LM
   Monti, J
   Japtok, L
   Langgartner, D
   Füchsl, AM
   Kleuser, B
   Gulbins, E
   Hellerbrand, C
   Reber, SO
   Kornhuber, J
AF Reichel, Martin
   Rhein, Cosima
   Hofmann, Lena M.
   Monti, Juliana
   Japtok, Lukasz
   Langgartner, Dominik
   Fuechsl, Andrea M.
   Kleuser, Burkhard
   Gulbins, Erich
   Hellerbrand, Claus
   Reber, Stefan O.
   Kornhuber, Johannes
TI Chronic Psychosocial Stress in Mice Is Associated With Increased Acid
   Sphingomyelinase Activity in Liver and Serum and With Hepatic
   C16:0-Ceramide Accumulation
SO FRONTIERS IN PSYCHIATRY
LA English
DT Article
DE chronic psychosocial stress; acid sphingomyelinase; ceramide;
   sphingolipid metabolism; chronic subordinate colony housing (CSC); liver
   metabolism
ID CERAMIDE SYNTHASES; SECRETORY SPHINGOMYELINASE; INDUCED APOPTOSIS; MILD
   STRESS; SYSTEM; DISEASE; CELLS; STEATOHEPATITIS; SUSCEPTIBILITY;
   HOMEOSTASIS
AB Chronic psychosocial stress adversely affects human morbidity and is a risk factor for inflammatory disorders, liver diseases, obesity, metabolic syndrome, and major depressive disorder (MDD). In recent studies, we found an association of MDD with an increase of acid sphingomyelinase (ASM) activity. Thus, we asked whether chronic psychosocial stress as a detrimental factor contributing to the emergence of MDD would also affect ASM activity and sphingolipid (SL) metabolism. To induce chronic psychosocial stress in male mice we employed the chronic subordinate colony housing (CSC) paradigm and compared them to non-stressed single housed control (SHC) mice. We determined Asm activity in liver and serum, hepatic SL concentrations as well as hepatic mRNA expression of genes involved in SL metabolism. We found that hepatic Asm activity was increased by 28% (P = 0.006) and secretory Asm activity by 47% (P = 0.002) in stressed mice. C16:0-Cer was increased by 40% (P = 0.008). Gene expression analysis further revealed an increased expression of tumor necrosis factor (TNF)-alpha (P = 0.009) and of several genes involved in SL metabolism (Cers5, P = 0.028; Cers6, P = 0.045; Gba, P = 0.049; Gba2, P = 0.030; Ormdl2, P = 0.034; Smpdl3B; P = 0.013). Our data thus provides first evidence that chronic psychosocial stress, at least in mice, induces alterations in SL metabolism, which in turn might be involved in mediating the adverse health effects of chronic psychosocial stress and peripheral changes occurring in mood disorders.
C1 [Reichel, Martin; Rhein, Cosima; Hofmann, Lena M.; Monti, Juliana; Kornhuber, Johannes] Friedrich Alexander Univ Erlangen Nurnberg, Dept Psychiat & Psychotherapy, Erlangen, Germany.
   [Reichel, Martin] Charite Univ Med Berlin, Dept Nephrol & Med Intens Care, Berlin, Germany.
   [Japtok, Lukasz; Kleuser, Burkhard] Univ Potsdam, Inst Nutr Sci, Nuthetal, Germany.
   [Langgartner, Dominik; Fuechsl, Andrea M.; Reber, Stefan O.] Univ Ulm, Lab Mol Psychosomat, Clin Psychosomat Med & Psychotherapy, Ulm, Germany.
   [Fuechsl, Andrea M.] Univ Hosp Regensburg, Dept Internal Med 1, Regensburg, Germany.
   [Gulbins, Erich] Univ Duisburg Essen, Dept Mol Biol, Essen, Germany.
   [Hellerbrand, Claus] Friedrich Alexander Univ Erlangen Nurnberg, Emil Fischer Zentrum, Inst Biochem, Erlangen, Germany.
C3 University of Erlangen Nuremberg; Berlin Institute of Health; Free
   University of Berlin; Humboldt University of Berlin; Charite
   Universitatsmedizin Berlin; University of Potsdam; Ulm University;
   University of Regensburg; University of Duisburg Essen; University of
   Erlangen Nuremberg
RP Rhein, C (corresponding author), Friedrich Alexander Univ Erlangen Nurnberg, Dept Psychiat & Psychotherapy, Erlangen, Germany.
EM cosima.rhein@uk-erlangen.de
RI Kornhuber, Johannes/JAC-7814-2023
OI Reichel, Martin/0000-0001-7886-2784; Rhein, Cosima/0000-0002-3010-2169;
   Kleuser, Burkhard/0000-0002-1888-9595
FU DFG [GU 335/29-1, KO 947/13-1]; BMBF [01EE1401G, 01EE1401C]
FX The authors are grateful to N. Grunwald for excellent technical support.
   This study was supported by DFG grants GU 335/29-1 to EG and KO 947/13-1
   to JK and BMBF grants 01EE1401G to EG and 01EE1401C to JK.
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NR 52
TC 12
Z9 14
U1 0
U2 3
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-0640
J9 FRONT PSYCHIATRY
JI Front. Psychiatry
PD OCT 16
PY 2018
VL 9
AR 496
DI 10.3389/fpsyt.2018.00496
PG 8
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA GX0PR
UT WOS:000447413900001
PM 30386262
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Igosheva, N
   Taylor, PD
   Poston, L
   Glover, V
AF Igosheva, Natalia
   Taylor, Paul D.
   Poston, Lucilla
   Glover, Vivette
TI Prenatal stress in the rat results in increased blood pressure
   responsiveness to stress and enhanced arterial reactivity to
   neuropeptide Y in adulthood
SO JOURNAL OF PHYSIOLOGY-LONDON
LA English
DT Article
ID PITUITARY-ADRENAL AXIS; CORONARY-HEART-DISEASE; METABOLIC SYNDROME;
   CARDIOVASCULAR PARAMETERS; DEVELOPMENTAL ORIGINS; GESTATIONAL STRESS;
   ACUTE HYPOXEMIA; NERVOUS-SYSTEM; ALTERS; DEXAMETHASONE
AB We have shown previously that stress in the pregnant rat leads to a heightened cardiovascular response to restraint in adult offspring. The present study was undertaken to explore further the persistent cardiovascular effects of prenatal stress, with a focus on peripheral vascular function. Sprague-Dawley female rats were exposed to restraint/bright light three times daily in the last week of pregnancy. Litters from stressed and control females were cross-fostered to control dams to eliminate possible effects of maternal stress on nursing behaviour. At 120 days, offspring cardiovascular variables were measured by radiotelemetry. Reactivity of mesenteric small arteries was assessed by myography, and responses to electrical field stimulation determined. Resting cardiovascular parameters in prenatally stressed (PS) offspring were similar to controls but PS rats showed a greater increase in systolic blood pressure following restraint stress (P < 0.05). Recovery was also prolonged in PS animals compared with controls and was of longer duration in PS females than in PS males (P < 0.05). Adult PS females, but not males, also had elevated basal plasma corticosterone levels in comparison with controls (P < 0.05). Vascular reactivity to neuropeptide Y (P < 0.05) and electrical field stimulation (P < 0.05) in mesenteric arteries was also significantly increased in PS animals. Vascular responses to adrenergic agonists as well as endothelial dilator function did not differ between PS and controls. We conclude that prenatal stress during late gestation has long-lasting effects on cardiovascular responsiveness and vascular reactivity to neuropeptide Y in the offspring.
C1 St Thomas Hosp, Maternal & Fetal Res Unit, Div Reprod & Endocrinol, Univ London Kings Coll, London SE1 7EH, England.
   Univ London Imperial Coll Sci Technol & Med, Inst Reprod & Dev Biol, London W12 0NN, England.
C3 Guy's & St Thomas' NHS Foundation Trust; University of London; King's
   College London; Imperial College London
RP Igosheva, N (corresponding author), St Thomas Hosp, Maternal & Fetal Res Unit, Div Reprod & Endocrinol, Univ London Kings Coll, Lambeth Palace Rd, London SE1 7EH, England.
EM natalia.igosheva@kcl.ac.uk
RI Taylor, Paul/KLD-7393-2024; Glover, Vivette/M-2711-2016
OI Taylor, Paul David/0000-0002-4740-4307; Poston,
   Lucilla/0000-0003-1100-2821
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NR 53
TC 38
Z9 41
U1 0
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-3751
EI 1469-7793
J9 J PHYSIOL-LONDON
JI J. Physiol.-London
PD JUL 15
PY 2007
VL 582
IS 2
BP 665
EP 674
DI 10.1113/jphysiol.2007.130252
PG 10
WC Neurosciences; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Physiology
GA 187AK
UT WOS:000247819500020
PM 17495046
OA Green Published
DA 2025-06-11
ER

PT J
AU Stroeve, JHM
   van Wietmarschen, H
   Kremer, BHA
   van Ommen, B
   Wopereis, S
AF Stroeve, Johanna H. M.
   van Wietmarschen, Herman
   Kremer, Bas H. A.
   van Ommen, Ben
   Wopereis, Suzan
TI Phenotypic flexibility as a measure of health: the optimal nutritional
   stress response test
SO GENES AND NUTRITION
LA English
DT Article
DE Phenotypic flexibility; Metabolic challenge; OGTT; Metabolic health;
   Nutritional stress response test
ID ORAL GLUCOSE-TOLERANCE; TYPE-2 DIABETES-MELLITUS; HIGH-FAT; OXIDATIVE
   STRESS; POSTPRANDIAL LIPEMIA; INFLAMMATORY MARKERS; ENDOTHELIAL
   FUNCTION; METABOLIC SYNDROME; OBESE MEN; OLIVE OIL
AB Nutrition research is struggling to demonstrate beneficial health effects, since nutritional effects are often subtle and long term. Health has been redefined as the ability of our body to cope with daily-life challenges. Physiology acts as a well-orchestrated machinery to adapt to the continuously changing environment. We term this adaptive capacity "phenotypic flexibility.'' The phenotypic flexibility concept implies that health can be measured by the ability to adapt to conditions of temporary stress, such as physical exercise, infections or mental stress, in a healthy manner. This may offer a more sensitive way to assess changes in health status of healthy subjects. Here, we performed a systematic review of 61 studies applying different nutritional stress tests to quantify health and nutritional health effects, with the objective to define an optimal nutritional stress test that has the potential to be adopted as the golden standard in nutrition research. To acknowledge the multi-target role of nutrition, a relevant subset of 50 processes that govern optimal health, with high relevance to diet, was used to define phenotypic flexibility. Subsequently, we assessed the response of biomarkers related to this subset of processes to the different challenge tests. Based on the obtained insights, we propose a nutritional stress test composed of a high-fat, high-caloric drink, containing 60 g palm olein, 75 g glucose and 20 g dairy protein in a total volume of 400 ml. The use of such a standardized nutritional challenge test in intervention studies is expected to demonstrate subtle improvements of phenotypic flexibility, thereby enabling substantiation of nutritional health effects.
C1 [Stroeve, Johanna H. M.; van Wietmarschen, Herman; Kremer, Bas H. A.; van Ommen, Ben; Wopereis, Suzan] TNO, NL-3700 AJ Zeist, Netherlands.
C3 Netherlands Organization Applied Science Research
RP Wopereis, S (corresponding author), TNO, POB 360, NL-3700 AJ Zeist, Netherlands.
EM suzan.wopereis@tno.nl
RI van Wietmarschen, Herman/KBQ-4108-2024
FU TNO roadmap Nutrition and Health; Abbott Nutrition; Dupont Health and
   Nutrition; DSM; FrieslandCampina; Nestle Institute of Health Sciences;
   European Commission [289511]
FX The work was sponsored by TNO roadmap Nutrition and Health and co-funded
   by Abbott Nutrition, Dupont Health and Nutrition, DSM, FrieslandCampina
   and Nestle Institute of Health Sciences. The authors acknowledge the
   NutriTech project, financed by the European Commission in the 7th
   Framework Programme FP7, Grant Agreement No.: 289511. The authors thank
   Michael Muller (University of East Anglia), Hannelore Daniel (Technical
   University Munich), Christian Drevon (University of Oslo), Ricardo Rueda
   (Abbott Nutrition), Arthur Ouwehand and Kirsti Tiihonen (Dupont Health
   and Nutrition), Peter Weber (DSM), Jan Geurts (FrieslandCampina) and
   Serge Rezzi and Colleen Draper (Nestle Institute of Health Sciences) for
   useful discussions. The authors thank Marjan van Erk for careful reading
   of the manuscript, Gertruud Bakker for her contributions to the section
   on OPTT, Marisa Marcondes Rezende for final editing, and Annette Stafleu
   and Marjan van Erk for coordination of the PhenFlex project.
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NR 93
TC 95
Z9 103
U1 0
U2 9
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1865-3499
J9 GENES NUTR
JI Genes Nutr.
PD MAY
PY 2015
VL 10
IS 3
AR 13
DI 10.1007/s12263-015-0459-1
PG 21
WC Genetics & Heredity; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Genetics & Heredity; Nutrition & Dietetics
GA CG9NE
UT WOS:000353641700004
PM 25896408
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Ramos-Sepúlveda, JA
   Ramírez-Vélez, R
   Correa-Bautista, JE
   Izquierdo, M
   García-Hermoso, A
AF Alexander Ramos-Sepulveda, Jeison
   Ramirez-Velez, Robinson
   Enrique Correa-Bautista, Jorge
   Izquierdo, Mikel
   Garcia-Hermoso, Antonio
TI Physical fitness and anthropometric normative values among
   Colombian-Indian schoolchildren
SO BMC PUBLIC HEALTH
LA English
DT Article
DE Physical fitness; Body composition; Obesity; Adolescent; Reference
   standards
ID BODY-MASS INDEX; CHILDHOOD OBESITY IMPLICATIONS; CARDIOMETABOLIC
   RISK-FACTORS; CARDIORESPIRATORY FITNESS; CARDIOVASCULAR-DISEASE; SPANISH
   ADOLESCENTS; MUSCULAR FITNESS; CHILDREN; HEALTH; RACE
AB Background: Substantial evidence indicates that children's physical fitness levels are markers of their lifestyles and their cardio-metabolic health profile and are predictors of the future risk of chronic diseases such as obesity, cardiometabolic disease, skeletal health and mental health. However, fitness reference values for ethnic children and adolescents have not been published in a Latin-American population. Therefore, the aim of the study was to provide sex-and age-specific physical fitness and anthropometric reference standards among Colombian-Indian schoolchildren.
   Methods: A sample of 576 participants (319 boys and 257 girls) aged 10 to 17 years old was assessed using the FUPRECOL test battery. Four components of physical fitness were measured: 1) morphological component: height, weight, body mass index (BMI), waist circumference (WC), triceps skinfold, subscapular skinfold, and body fat (%); 2) musculoskeletal component: handgrip and standing long jump test; 3) motor component: speed/agility test (4 x 10 m shuttle run); and 4) cardiorespiratory component: course-navette 20 m, shuttle run test and estimation of maximal oxygen consumption by VO(2)max indirect. Centile smoothed curves for the 3rd, 10th, 25th, 50th, 75th, 90th and 97th percentiles were calculated using Cole's LMSmethod.
   Results: Our results show that weight, height and BMI in each age group were higher in boys than in girls. In each groups, age showed a significant effect for BMI and WC. Boys showed better than girls in cardiorespiratory fitness, lowerand upper-limb strength and speed/agility and girls performed better in low back flexibility.
   Conclusion: Our results provide for the first time sex-and age-specific physical fitness and anthropometric reference values for Colombian Nasa Indian children and adolescents aged 10-17.9 years.
C1 [Alexander Ramos-Sepulveda, Jeison] Inst Univ Antonio Jose Camacho, Grp Invest Pedagogia Licenciatura Ciencias Deport, Cali, Colombia.
   [Alexander Ramos-Sepulveda, Jeison] Univ Manuela Beltran, Vicerrectoria Invest Maestria Ciencias & Tecnol D, Bogota, Dc, Colombia.
   [Ramirez-Velez, Robinson; Enrique Correa-Bautista, Jorge] Univ Rosario, Escuela Med & Ciencias Salud, Ctr Estudios Med Act Fis CEMA, Bogota, Dc, Colombia.
   [Izquierdo, Mikel] Univ Publ Navarra, Dept Hlth Sci, Pamplona, Spain.
   [Garcia-Hermoso, Antonio] Univ Santiago Chile, USACH, Lab Ciencias Actividad Fis el Deporte & Salud, Santiago, Chile.
   [Garcia-Hermoso, Antonio] Univ San Sebastian, Santiago, Chile.
C3 Universidad Manuela Beltran - UMB; Universidad del Rosario; Universidad
   Publica de Navarra; Universidad de Santiago de Chile; Universidad San
   Sebastian
RP Ramírez-Vélez, R (corresponding author), Univ Rosario, Escuela Med & Ciencias Salud, Ctr Estudios Med Act Fis CEMA, Bogota, Dc, Colombia.
EM robin640@hotmail.com
RI García-Hermoso, Antonio/ADU-2591-2022; Correa-Bautista, Jorge
   Enrique/N-2741-2015; Izquierdo, Mikel/A-4894-2010; Garcia-Hermoso,
   Antonio/P-1857-2017; Ramirez-Velez, Robinson/D-5311-2016
OI Correa-Bautista, Jorge Enrique/0000-0002-0646-2316; Izquierdo,
   Mikel/0000-0002-1506-4272; Garcia-Hermoso, Antonio/0000-0002-1397-7182;
   Ramos-Sepulveda, Jeison Alexander/0000-0003-2734-7912; Ramirez-Velez,
   Robinson/0000-0003-3075-6960
FU Instituto Colombiano para el Desarrollo de la Ciencia y la Tecnologia
   "Francisco Jose de Caldas" COLCIENCIAS [671-2014, 122265743978]
FX The "Fuprecol Study" was carried out with the financial support of
   Instituto Colombiano para el Desarrollo de la Ciencia y la Tecnologia
   "Francisco Jose de Caldas" COLCIENCIAS (Contract No 671-2014 Code
   122265743978).
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NR 78
TC 47
Z9 49
U1 0
U2 17
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2458
J9 BMC PUBLIC HEALTH
JI BMC Public Health
PD SEP 13
PY 2016
VL 16
AR 962
DI 10.1186/s12889-016-3652-2
PG 15
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA DX4NU
UT WOS:000384359200002
PM 27619491
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Codoñer-Franch, P
   Tavárez-Alonso, S
   Murria-Estal, R
   Megías-Vericat, J
   Tortajada-Girbés, M
   Alonso-Iglesias, E
AF Codoner-Franch, Pilar
   Tavarez-Alonso, Sandra
   Murria-Estal, Rosa
   Megias-Vericat, Javier
   Tortajada-Girbes, Miguel
   Alonso-Iglesias, Eulalia
TI Nitric oxide production is increased in severely obese children and
   related to markers of oxidative stress and inflammation
SO ATHEROSCLEROSIS
LA English
DT Article
DE Children; Nitric oxide; Obesity; Oxidative stress; Tumor necrosis factor
   alpha
ID INSULIN-RESISTANCE; METABOLIC SYNDROME; PLASMA; SERUM; MODEL; WEIGHT;
   INDEX
AB Objective: Nitric oxide (NO) is the major endothelium-derived relaxing factor. The aim of the present study was to evaluate NO synthesis and metabolism in severely obese children with different degrees of metabolic risk and to ascertain their relation with the parameters of oxidative stress and inflammation.
   Methods: The study involved 60 obese children evaluated with respect to metabolic risk factors (MRFs) (32 < 4 MRFs and 28 >= 4 MRFs) and 50 normal weight children between 7 and 14 years of age. Nutritional status was assessed by clinical and anthropometric examination. MRFs (serum lipid profile, insulin resistance indexes, blood pressure) in addition to uric acid, homocysteine, leptin, and inflammatory markers were measured. Plasma nitrite, nitrate and nitrotyrosine concentrations, and urinary nitrate were determined as markers of NO production and nitrosative stress. Malondialdehyde, 8-isoprostane F-2 alpha, and advanced oxidation protein products were analyzed in plasma to assess oxidative stress.
   Results: Compared with healthy controls, the obese children had significantly increased concentrations of markers of NO synthesis and nitrosative and oxidative stress that were correlated with each another. Increased NO production in obese children was associated with MRFs; plasma nitrate to waist circumference (r = 0.388, p = 0.003), uric acid (r = 0.404, p < 0.001), and tumor necrosis factor alpha. (r = 0.302, p = 0.021), and plasma nitrite to triglycerides (r = 0.432, p < 0.001).
   Conclusion: NO synthesis and nitrosative stress are increased in severely obese children and correlated with anthropometric parameters indicative of abdominal obesity, oxidative stress and inflammatory markers. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
C1 [Codoner-Franch, Pilar; Tortajada-Girbes, Miguel] Dr Peset Univ Hosp, Dept Pediat, Valencia 46017, Spain.
   [Codoner-Franch, Pilar] Univ Valencia, Dept Pediat Obstet & Gynecol, Valencia 46010, Spain.
   [Tavarez-Alonso, Sandra; Alonso-Iglesias, Eulalia] Univ Valencia, Dept Biochem & Mol Biol, Valencia 46010, Spain.
   [Murria-Estal, Rosa] Dr Peset Univ Hosp, Clin Biochem Lab, Valencia 46017, Spain.
   [Megias-Vericat, Javier] Ctr Invest Principe Felipe, Mix Unit CIPF UVEG, Lab Cyt, Valencia 46012, Spain.
C3 University of Valencia; University of Valencia; Prince Felipe Research
   Center
RP Codoñer-Franch, P (corresponding author), Dr Peset Univ Hosp, Dept Pediat, Ave Gaspar Aguilar 90, Valencia 46017, Spain.
EM pilar.codoner@uv.es
RI /L-9758-2014; Codoner-Franch, Pilar/K-9333-2014
OI Codoner-Franch, Pilar/0000-0002-1549-1573
FU EVES [945/2008]; Conselleria de Sanitat; Generalitat Valenciana; MEC,
   Spain [CSD 2007-00063]
FX This research was supported by grants 945/2008 from EVES, Conselleria de
   Sanitat, Generalitat Valenciana, and by CSD 2007-00063 Research Activity
   Programme (CONSOLIDER-INGENIO), MEC, Spain.
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NR 30
TC 91
Z9 100
U1 0
U2 15
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0021-9150
EI 1879-1484
J9 ATHEROSCLEROSIS
JI Atherosclerosis
PD APR
PY 2011
VL 215
IS 2
BP 475
EP 480
DI 10.1016/j.atherosclerosis.2010.12.035
PG 6
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 742KC
UT WOS:000288940000033
PM 21300354
DA 2025-06-11
ER

PT J
AU Behera, S
   Kapadia, B
   Kain, V
   Alamuru-Yellapragada, NP
   Murunikkara, V
   Kumar, ST
   Babu, PP
   Seshadri, S
   Shivarudraiah, P
   Hiriyan, J
   Gangula, NR
   Maddika, S
   Misra, P
   Parsa, KVL
AF Behera, Soma
   Kapadia, Bandish
   Kain, Vasundhara
   Alamuru-Yellapragada, Neeraja P.
   Murunikkara, Vachana
   Kumar, Sireesh T.
   Babu, Phanithi Prakash
   Seshadri, Sriram
   Shivarudraiah, Prasad
   Hiriyan, Jagadheshan
   Gangula, Narmadha Reddy
   Maddika, Subbareddy
   Misra, Parimal
   Parsa, Kishore V. L.
TI ERK1/2 activated PHLPP1 induces skeletal muscle ER stress through the
   inhibition of a novel substrate AMPK
SO BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
LA English
DT Article
DE PHLPP1; ER stress; AMPK; Insulin resistance; ERK
ID ENDOPLASMIC-RETICULUM STRESS; INDUCED INSULIN-RESISTANCE; PROTEIN
   PHOSPHATASE 2A; PHOSPHORYLATION SITES; METABOLIC SYNDROME; HEPATIC
   STEATOSIS; 3T3-L1 ADIPOCYTES; GLUT4 EXPRESSION; CELL-SURVIVAL; CANCER
   CELLS
AB Nutritional abundance associated with chronic inflammation and dyslipidemia impairs the functioning of endoplasmic reticulum (ER) thereby hampering cellular responses to insulin. PHLPP1 was identified as a phosphatase which inactivates Akt, the master regulator of insulin mediated glucose homeostasis. Given the suggestive role of PHLPP1 phosphatase in terminating insulin signalling pathways, deeper insights into its functional role in inducing insulin resistance are warranted. Here, we show that PHLPP1 expression is enhanced in skeletal muscle of insulin resistant rodents which also displayed ER stress, an important mediator of insulin resistance. Using cultured cells and PHLPP1 knockdown mice, we demonstrate that PHLPP1 facilitates the development of ER stress. Importantly, shRNA mediated ablation of PHLPP1 significantly improved glucose clearance from systemic circulation with enhanced expression of glucose transporter 4 (GLUT-4) in skeletal muscle. Mechanistically, we show that endogenous PHLPP1 but not PP2Ca interacts with and directly dephosphorylates AMPK Thr(172) in myoblasts without influencing its upstream kinase, LKB1. While the association between endogenous PHLPP1 and AMPK was enhanced in ER stressed cultured cells and soleus muscle of high fat diet fed mice, the basal interaction between PP2Ac and AMPK was minimally altered. Further, we show that PHLPP1 a is phosphorylated by ERK1/2 at Ser(932) under ER stress which is required for its ability to interact with and dephosphorylate AMPK and thereby induce ER stress. Taken together, our data position PHLPP1 as a key regulator of ER stress.
C1 [Behera, Soma; Kapadia, Bandish; Kain, Vasundhara; Alamuru-Yellapragada, Neeraja P.; Murunikkara, Vachana; Misra, Parimal; Parsa, Kishore V. L.] DRILS, Dept Biol, Univ Hyderabad Campus, Hyderabad 500046, Andhra Pradesh, India.
   [Alamuru-Yellapragada, Neeraja P.; Gangula, Narmadha Reddy; Maddika, Subbareddy] CDFD, Lab Cell Death & Cell Survival, Hyderabad 500001, Andhra Pradesh, India.
   [Kumar, Sireesh T.; Babu, Phanithi Prakash] Univ Hyderabad, Dept Biotechnol, Hyderabad 500046, Andhra Pradesh, India.
   [Seshadri, Sriram] Nirma Univ, Inst Sci, Ahmadabad 382481, Gujarat, India.
   [Shivarudraiah, Prasad; Hiriyan, Jagadheshan] Anthem Biosci Pvt Ltd, Bommasandra Ind Area Phase 1, Bangalore 560099, Karnataka, India.
   [Kapadia, Bandish] Univ Maryland, Dept Med, Marlene & Stewart Greenebaum Canc Ctr, Baltimore, MD 21201 USA.
   [Kain, Vasundhara] Univ Alabama Birmingham, Sch Med, Div Cardiovasc Dis, Birmingham, AL USA.
C3 Department of Biotechnology (DBT) India; Centre for DNA Fingerprinting &
   Diagnostics (CDFD); University of Hyderabad; Nirma University;
   University System of Maryland; University of Maryland Baltimore;
   University of Alabama System; University of Alabama Birmingham
RP Parsa, KVL (corresponding author), DRILS, Dept Biol, Univ Hyderabad Campus, Hyderabad 500046, Andhra Pradesh, India.
EM kishorep@drils.org
RI Kapadia, Bandish/I-7965-2019; Seshadri, Sriram/A-2526-2010; Kain,
   Vasundhara/AAL-7371-2021
OI Kapadia, Bandish/0000-0001-6021-0008; Parsa,
   Kishore/0000-0001-7883-2534; Seshadri, Sriram/0000-0003-1547-2193
FU CSIR; DBT [BT/PR13527/, BRB/10/765/2010, BT/PR17686/MED/30/1663/2016,
   BT/PR14123/Med/29/193/2010, BT/PR15214/BRB/10/903/2011]; CSIR
   [37(1634)/14/EMR-II]
FX KVLP and PM appreciate the helpful comments from the members of their
   laboratory. The authors also thank Drs. Alexandra Newton, John Blenis
   and Didier Trono for gifting plasmids. SB, BK, and NPAY acknowledge
   their finanacial assistance from CSIR for JRF/SRF fellowship. VK and VM
   acknowledge financial support from DBT (RA; BT/PR13527/;
   BRB/10/765/2010) and CSIR (RA; 37(1634)/14/EMR-II), resepctively. KVLP,
   PBP and PM acknowledge the financial support from DBT
   (BT/PR17686/MED/30/1663/2016 to KVLP, PBP and PM;
   BT/PR14123/Med/29/193/2010 to KP and BT/PR15214/BRB/10/903/2011 to PM).
   KVLP and SB thank Dr. Kiranam Chatti for the technical inputs in the
   kinase assays. The authors also thank Drs. Kiranam Chatti and Manjunatha
   Thondamal for critical reading of the manuscript.
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NR 76
TC 23
Z9 23
U1 0
U2 7
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0925-4439
EI 1879-260X
J9 BBA-MOL BASIS DIS
JI Biochim. Biophys. Acta-Mol. Basis Dis.
PD MAY
PY 2018
VL 1864
IS 5
BP 1702
EP 1716
DI 10.1016/j.bbadis.2018.02.019
PN A
PG 15
WC Biochemistry & Molecular Biology; Biophysics; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Cell Biology
GA GE0DB
UT WOS:000430883100016
PM 29499326
OA Bronze
DA 2025-06-11
ER

PT J
AU Lippmann, M
   Chen, LC
AF Lippmann, Morton
   Chen, Lung-Chi
TI Health effects of concentrated. ambient air particulate matter (CAPs)
   and its components
SO CRITICAL REVIEWS IN TOXICOLOGY
LA English
DT Review
DE Accumulation mode PM; CAPs; cardiovascular effects; coarse thoracic PM;
   fine PM; hepatic system effects; nervous system effects; PMx; pulmonary
   effects; ultrafine PM concentration
ID OIL FLY-ASH; HEART-RATE-VARIABILITY; DIESEL-EXHAUST INHALATION; ACUTE
   ARTERIAL VASOCONSTRICTION; SOURCE-SPECIFIC PARTICLES; CARDIAC OXIDATIVE
   STRESS; ST-SEGMENT DEPRESSION; SHORT-TERM INHALATION; KAPPA-B
   ACTIVATION; SUBCHRONIC EXPOSURES
AB We review literature that provides insights on health-related effects observed in laboratory-based inhalation studies in humans and laboratory animals using concentrated ambient air particulate matter (CAPs) in the fine, thoracic coarse, and ultrafine size ranges. The CAPs studies are highly informative on the health effects of ambient air particulate matter (PM) because they represent realistic PM exposure mixtures. When PM components are also analyzed and regressed against the effects, they can sometimes be used to identify influential individual components or source-related mixtures responsible for the effects. Such CAPs inhalation studies are analogous to epidemiological studies of human populations for which both health-related effects were observed and PM composition data were available for multi-pollutant regression analyses or source apportionment. Various acute and chronic health-related effects have occurred in short- and long-term CAPs inhalation studies in the cardiovascular, nervous, hepatic, and pulmonary systems, as well as changes in markers of the metabolic syndrome, and many correspond to effects associated with ambient air PM exposures in epidemiological studies. In addition, many CAPs studies have been conducted in coordination with in vitro studies that have identified biomarkers indicative of the underlying biological mechanisms that account for the responses.
C1 [Lippmann, Morton; Chen, Lung-Chi] NYU, Sch Med, Dept Environm Med, Tuxedo Pk, NY 10987 USA.
C3 New York University
RP Lippmann, M (corresponding author), NYU, Sch Med, Dept Environm Med, 57 Old Forge Rd, Tuxedo Pk, NY 10987 USA.
EM morton.lippmann@nyumc.org
OI Chen, Lung Chi/0000-0003-1154-2107
FU NIEHS NIH HHS [R01 ES015495, ES 00260] Funding Source: Medline
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NR 201
TC 126
Z9 147
U1 1
U2 53
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1040-8444
EI 1547-6898
J9 CRIT REV TOXICOL
JI Crit. Rev. Toxicol.
PD NOV
PY 2009
VL 39
IS 10
BP 865
EP 913
DI 10.3109/10408440903300080
PG 49
WC Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Toxicology
GA 531ZS
UT WOS:000272713100002
PM 19863385
DA 2025-06-11
ER

PT J
AU Uchida, Y
   Takeshita, K
   Yamamoto, K
   Kikuchi, R
   Nakayama, T
   Nomura, M
   Cheng, XW
   Egashira, K
   Matsushita, T
   Nakamura, H
   Murohara, T
AF Uchida, Yasuhiro
   Takeshita, Kyosuke
   Yamamoto, Koji
   Kikuchi, Ryosuke
   Nakayama, Takayuki
   Nomura, Mieko
   Cheng, Xian Wu
   Egashira, Kensuke
   Matsushita, Tadashi
   Nakamura, Hideo
   Murohara, Toyoaki
TI Stress Augments Insulin Resistance and Prothrombotic State
SO DIABETES
LA English
DT Article
ID MONOCYTE CHEMOATTRACTANT PROTEIN-1; PLASMINOGEN-ACTIVATOR INHIBITOR-1;
   NECROSIS-FACTOR-ALPHA; DOMINANT-NEGATIVE INHIBITOR; MESENCHYMAL
   STEM-CELLS; ADIPOSE-TISSUE; METABOLIC SYNDROME; DB/DB MICE; EXPRESSION;
   OBESITY
AB Stressors contribute to thrombosis and insulin resistance. Since obesity-related adipose inflammation is also involved in these pathological states, we assumed that stress correlates with adipose inflammation. Male mice were subjected to 2-week intermittent restraint stress. Expression of plasma lipids, rnonocyte/macrophage markers (CD11b, CD68, and F4/80), proinflammatory cytokines (monocyte chemoattractant protein-1 [MCP-1], tumor necrosis factor-alpha, and interleukin-6), adiponectin, heat shock protein 70.1 (HSP70.1), and coagulation factors (plasminogen activation inhibitor-1 [PAI-1] and tissue factor [TF]) in blood and inguinal white adipose tissue (WAT) was determined using immunohistochemistry, enzyme-linked immunosorbent assay, and RT-PCR, respectively. Glucose metabolism was assessed by glucose tolerance tests (GTTs) and insulin tolerance tests, and expression of insulin receptor substrate-1 (IRS-1) and glucose transporter 4 (GLUT4) in WAT. To examine effects of MCP-1 blockade, animals were treated with control or neutralizing antibody, or transplanted with control or 7ND (dominant-negative form of MCP-1)-overexpressing adipose-derived stromal cells (ADSCs). Stress increased monocyte accumulation, free fatty acids, proinflammatory cytokine, and HSP70.1 and reduced adiponectin. Adipose stromal cells highly expressed MCP-1. The stress-induced adipose inflammation increased PAI-1 and TF but did not give rise to thrombus formation. Without any changes in GTT, stress worsened insulin sensitivity and decreased IRS-1 and GLUT4 in WAT. Neutralizing antibody and 7ND-ADSCs reversed stress-induced adipose inflammation, procoagulant state, and insulin resistance. Stress evoked adipose inflammation to increase coagulation factors and impair insulin sensitivity through adipose-derived MCP-1. Diabetes 61:1552-1561, 2012
C1 [Uchida, Yasuhiro; Takeshita, Kyosuke; Kikuchi, Ryosuke; Cheng, Xian Wu; Murohara, Toyoaki] Nagoya Univ, Grad Sch Med, Dept Cardiol, Nagoya, Aichi 4648601, Japan.
   [Takeshita, Kyosuke] Nagoya Univ Hosp, Dept Clin Lab, Nagoya, Aichi, Japan.
   [Yamamoto, Koji; Nomura, Mieko; Matsushita, Tadashi] Nagoya Univ Hosp, Dept Blood Transfus, Nagoya, Aichi, Japan.
   [Nakayama, Takayuki] Nagoya Univ, Grad Sch Med, Dept Haematol, Nagoya, Aichi 4648601, Japan.
   [Egashira, Kensuke] Kyushu Univ, Grad Sch Med, Dept Cardiovasc Med, Fukuoka 812, Japan.
   [Nakamura, Hideo] Nagoya Univ Hosp, Dept Pathol, Nagoya, Aichi, Japan.
C3 Nagoya University; Nagoya University; Nagoya University; Nagoya
   University; Kyushu University; Nagoya University
RP Takeshita, K (corresponding author), Nagoya Univ, Grad Sch Med, Dept Cardiol, Nagoya, Aichi 4648601, Japan.
EM kyousuke@med.nagoya-u.ac.jp
RI Kikuchi, Ryosuke/AAX-4971-2021; Murohara, Toyoaki/M-4958-2014;
   Takeshita, Kyosuke/AAD-9515-2020; Matsushita, Tadadshi/I-7349-2014;
   Takeshita, Kyosuke/B-7008-2012
OI Takeshita, Kyosuke/0000-0002-8283-3799; Nakayama,
   Takayuki/0000-0003-2389-2542; Uchida, Yasuhiro/0000-0002-5973-1444
FU Takeda Research Foundation; Japan Cardiovascular Research Foundation; 
   [Kakenhi 21590950];  [23390208]; Grants-in-Aid for Scientific Research
   [22591059, 23591382] Funding Source: KAKEN
FX This work was supported by research grants from the Takeda Research
   Foundation, a grant from the Japan Cardiovascular Research Foundation
   (Bayer Scholarship for Cardiovascular Research to K.T.), and
   Grant-in-Aid for Scientific (Kakenhi 21590950 to K.T. and 23390208 to
   T.M.)
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NR 47
TC 79
Z9 85
U1 0
U2 10
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0012-1797
J9 DIABETES
JI Diabetes
PD JUN
PY 2012
VL 61
IS 6
BP 1552
EP 1561
DI 10.2337/db11-0828
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 948FX
UT WOS:000304490100033
PM 22396205
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Maghout-Juratli, S
   Janisse, J
   Schwartz, K
   Arnetz, BB
AF Maghout-Juratli, Sham
   Janisse, James
   Schwartz, Kendra
   Arnetz, Bengt B.
TI The Causal Role of Fatigue in the Stress-Perceived Health Relationship:
   A MetroNet Study
SO JOURNAL OF THE AMERICAN BOARD OF FAMILY MEDICINE
LA English
DT Article
DE Fatigue; Stress; Perceived Health
ID SELF-RATED HEALTH; PRIMARY-CARE; SOCIAL SUPPORT; PSYCHOLOGICAL DISTRESS;
   METABOLIC SYNDROME; SLEEP-DEPRIVATION; AFRICAN-AMERICANS;
   GENERAL-PRACTICE; PREVALENCE; MORTALITY
AB Background: We conducted a cross-sectional survey of 4 primary care MetroNet centers in metropolitan Detroit. Our objective was to describe the causal role of fatigue in the relationship among stress, stress resiliency, and perceived health in primary care. Fatigue is a public health problem that has been linked to stress and poor health. The causal role of fatigue between stress and perceived health is unknown.
   Methods: Four hundred surveys were distributed to adult patients in 4 primary care centers in metropolitan Detroit between 2006 and 2007. Internal consistency reliabilities and principal factor analyses were calculated for the key psychological scales. Perceived health is the primary outcome. Path models were used to study the relationship among stress, fatigue, and perceived health. We also modeled the impact of select stress resiliency factors including sleep, recovery, and social support.
   Results: Of the 400 distributed surveys, 315 (78.7%) had a response rate of 70% or more and were included in the analysis. Respondents were predominantly middle aged (median age, 43 years); female (58.7%); and African American (52.0%). The majority worked full time (56.5%); did not have a college degree (77.7%); and were not married (55.2%). Fatigue was reported by 59% of respondents, 42.7% of which was unexplained. The path model supported the causal role of fatigue between stress and perceived health. The positive effects of sleep, recovery, and social support on fatigue, stress, and perceived health were validated.
   Conclusion: Fatigue was common in this metropolitan primary care environment and completely mediated the relationship between stress and poor perceived health. Therefore, stress, when significant enough to cause fatigue, may lead to poor health. (J Am Board Fam Med 2010;23:212-219.)
C1 [Maghout-Juratli, Sham; Arnetz, Bengt B.] Wayne State Univ, Occupat & Environm Hlth Div, Detroit, MI 48201 USA.
   [Schwartz, Kendra] Wayne State Univ, Div Practice Based Res, Detroit, MI 48201 USA.
   [Maghout-Juratli, Sham; Janisse, James; Schwartz, Kendra; Arnetz, Bengt B.] Wayne State Univ, Dept Family Med & Publ Hlth Sci, Detroit, MI 48201 USA.
C3 Wayne State University; Wayne State University; Wayne State University
RP Maghout-Juratli, S (corresponding author), Wayne State Univ, Occupat & Environm Hlth Div, 3800 Woodward Ave,Suite 808, Detroit, MI 48201 USA.
EM smjuratli@med.wayne.edu
RI Arnetz, Bengt/G-1685-2011
FU Wayne State University School of Medicine; Skandia Insurance
FX Funding from Wayne State University School of Medicine research funds
   and Skandia Insurance.
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NR 57
TC 24
Z9 28
U1 1
U2 9
PU AMER BOARD FAMILY MEDICINE
PI LEXINGTON
PA 2228 YOUNG DR, LEXINGTON, KY 40505 USA
SN 1557-2625
J9 J AM BOARD FAM MED
JI J. Am. Board Fam. Med.
PD MAR-APR
PY 2010
VL 23
IS 2
BP 212
EP 219
DI 10.3122/jabfm.2010.02.090132
PG 8
WC Primary Health Care; Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA 564TW
UT WOS:000275241500012
PM 20207932
OA Green Submitted, Bronze
DA 2025-06-11
ER

PT J
AU Ruggiero, C
   Ehrenshaft, M
   Cleland, E
   Stadler, K
AF Ruggiero, Christine
   Ehrenshaft, Marilyn
   Cleland, Ellen
   Stadler, Krisztian
TI High-fat diet induces an initial adaptation of mitochondrial
   bioenergetics in the kidney despite evident oxidative stress and
   mitochondrial ROS production
SO AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
LA English
DT Article
DE reactive oxygen species; chronic kidney diseases; obesity; mitochondria
ID PROGRESSIVE RENAL-DISEASE; INSULIN-RESISTANCE; LIPID-METABOLISM;
   SKELETAL-MUSCLE; ACID OXIDATION; US ADULTS; OBESITY; MICE; TISSUE;
   IMMUNOLOCALIZATION
AB Obesity and metabolic syndrome are associated with an increased risk for several diabetic complications, including diabetic nephropathy and chronic kidney diseases. Oxidative stress and mitochondrial dysfunction are often proposed mechanisms in various organs in obesity models, but limited data are available on the kidney. Here, we fed a lard-based high-fat diet to mice to investigate structural changes, cellular and subcellular oxidative stress and redox status, and mitochondrial biogenesis and function in the kidney. The diet induced characteristic changes, including glomerular hypertrophy, fibrosis, and interstitial scarring, which were accompanied by a proinflammatory transition. We demonstrate evidence for oxidative stress in the kidney through 3-nitrotyrosine and protein radical formation on high-fat diet with a contribution from iNOS and NOX-4 as well as increased generation of mitochondrial oxidants on carbohydrate-and lipid-based substrates. The increased H(2)O(2) emission in the mitochondria suggests altered redox balance and mitochondrial ROS generation, contributing to the overall oxidative stress. No major derailments were observed in respiratory function or biogenesis, indicating preserved and initially improved bioenergetic parameters and energy production. We suggest that, regardless of the oxidative stress events, the kidney developed an adaptation to maintain normal respiratory function as a possible response to an increased lipid overload. These findings provide new insights into the complex role of oxidative stress and mitochondrial redox status in the pathogenesis of the kidney in obesity and indicate that early oxidative stress-related changes, but not mitochondrial bioenergetic dysfunction, may contribute to the pathogenesis and development of obesity-linked chronic kidney diseases.
C1 [Ruggiero, Christine; Cleland, Ellen; Stadler, Krisztian] Pennington Biomed Res Ctr, Oxidat Stress & Dis Lab, Baton Rouge, LA 70808 USA.
   [Ehrenshaft, Marilyn] NIEHS, Free Rad Metabolite Sect, Lab Toxicol & Pharmacol, NIH, Res Triangle Pk, NC 27709 USA.
C3 Louisiana State University System; Louisiana State University;
   Pennington Biomedical Research Center; National Institutes of Health
   (NIH) - USA; NIH National Institute of Environmental Health Sciences
   (NIEHS)
RP Stadler, K (corresponding author), Pennington Biomed Res Ctr, Oxidat Stress & Dis Lab, 6400 Perkins Rd, Baton Rouge, LA 70808 USA.
EM krisztian.stadler@pbrc.edu
RI Stadler, Krisztian/N-1992-2017
FU NIH [DK-083615, P20 RR-021945]; Pennington Foundation; NORC P F
   [2P30DK072476]; CNRU [NIH 1P30 DK-072476]
FX Research in this laboratory is supported partially by NIH (DK-083615) to
   K. Stadler and the Pennington Foundation and by a NORC P & F grant
   (2P30DK072476). The work utilized the facilities of the Cell Biology and
   Bioimaging Core, which are supported in part by COBRE (NIH P20
   RR-021945) and CNRU (NIH 1P30 DK-072476) center grants from the NIH.
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NR 45
TC 99
Z9 105
U1 1
U2 19
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0193-1849
J9 AM J PHYSIOL-ENDOC M
JI Am. J. Physiol.-Endocrinol. Metab.
PD JUN
PY 2011
VL 300
IS 6
BP E1047
EP E1058
DI 10.1152/ajpendo.00666.2010
PG 12
WC Endocrinology & Metabolism; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Physiology
GA 768SP
UT WOS:000290959000012
PM 21386058
OA Green Published
DA 2025-06-11
ER

PT J
AU Wan, ZF
   Wen, W
   Ren, KY
   Zhou, D
   Liu, JH
   Wu, Y
   Zhou, J
   Mu, JJ
   Yuan, ZY
AF Wan, Zhaofei
   Wen, Wen
   Ren, Keyu
   Zhou, Dong
   Liu, Junhui
   Wu, Yue
   Zhou, Juan
   Mu, Jianjun
   Yuan, Zuyi
TI Involvement of NLRP3 inflammasome in the impacts of sodium and potassium
   on insulin resistance in normotensive Asians
SO BRITISH JOURNAL OF NUTRITION
LA English
DT Article
DE Insulin resistance; NLRP3 inflammasome; Oxidative stress; Sodium;
   Potassium
ID OXIDATIVE STRESS; BLOOD-PRESSURE; CARDIOVASCULAR-DISEASE; METABOLIC
   SYNDROME; DIETARY-SODIUM; ACTIVATION; STROKE; RISK; METAANALYSIS;
   KIDNEYS
AB Salt, promoting oxidative stress, contributes to insulin resistance, whereas K, inhibiting oxidative stress, improves insulin sensitivity. Oxidative stress activation of NLRP3 inflammasome is a central player in the induction of insulin resistance. Therefore, we hypothesised that NLRP3 inflammasome may mediate the effects of salt and K on insulin resistance. In all, fifty normotensive subjects were recruited from a rural community of Northern China. The protocol included a low-salt diet for 7 d, then a high-salt diet for 7 d and a high-salt diet with K supplementation for another 7 d. In addition, THP-1 cells were cultured in different levels of Na with and without K. The results showed that salt loading elevated fasting blood glucose, insulin and C-peptide levels, as well as insulin resistance, whereas K supplementation reversed them. Meanwhile, additional K reversed the active effects of high salt on NLRP3 inflammasome in both the subjects and THP-1 cells, and the change of insulin resistance index notably related with the alteration of plasma IL-1 beta, the index of NLRP3 inflammasome activation, during intervention in the subjects. Additional K ameliorated oxidative stress induced by high salt in both the subjects and cultured THP-1 cells, and the change of oxidative stress related with the alteration of plasma IL-1 beta during intervention in the subjects. In vitro, antioxidant N-acetyl-l-cysteine significantly prevented the active effects of high Na or oxidant Rosup on NLRP3 inflammasome, so did K. Our study indicates that oxidative stress modulation of NLRP3 inflammasome may be involved in the impacts of Na and K on insulin resistance.
C1 [Wan, Zhaofei; Wen, Wen; Ren, Keyu; Zhou, Dong; Liu, Junhui; Wu, Yue; Zhou, Juan; Mu, Jianjun; Yuan, Zuyi] Xi An Jiao Tong Univ, Med Coll, Affiliated Hosp 1, Dept Cardiovasc Med, Xian 710061, Shaanxi, Peoples R China.
C3 Xi'an Jiaotong University
RP Mu, JJ; Yuan, ZY (corresponding author), Xi An Jiao Tong Univ, Med Coll, Affiliated Hosp 1, Dept Cardiovasc Med, Xian 710061, Shaanxi, Peoples R China.
EM mujjun@163.com; zuyiyuan@mail.xjtu.edu.cn
RI wen, Wen/KBB-1727-2024; Zhou, Dong/E-1069-2019
OI Yuan, Zuyi/0000-0002-4141-0298
FU National Program on Key Basic Research Project of China (973 Program)
   [2012CB517804]; National Science Fund for Distinguished Young Scholars
   [81025002]; NSFC [81370357, 81570381]
FX This work was supported in part by the National Program on Key Basic
   Research Project of China (973 Program: 2012CB517804 to Z.Y.); the
   National Science Fund for Distinguished Young Scholars (nos 81025002 to
   Z.Y.); and NSFC (nos 81370357 and 81570381 to J.M.).
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NR 41
TC 19
Z9 19
U1 0
U2 18
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1145
EI 1475-2662
J9 BRIT J NUTR
JI Br. J. Nutr.
PD JAN 28
PY 2018
VL 119
IS 2
BP 228
EP 237
DI 10.1017/S0007114517002926
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA FT5SX
UT WOS:000423214600013
PM 29359681
OA Bronze
DA 2025-06-11
ER

PT J
AU Vachirayonsti, T
   Ho, KW
   Yang, DF
   Yan, BF
AF Vachirayonsti, Thaveechai
   Ho, Karen W.
   Yang, Dongfang
   Yan, Bingfang
TI Suppression of the Pregnane X Receptor during Endoplasmic Reticulum
   Stress Is Achieved by Down-Regulating Hepatocyte Nuclear Factor-4α and
   Up-Regulating Liver-Enriched Inhibitory Protein
SO TOXICOLOGICAL SCIENCES
LA English
DT Article
DE PXR; ER stress; CYP3A4; proinflammatory cytokines; STAT3
ID ER STRESS; MOLECULAR-BASIS; EXPRESSION; PXR; IDENTIFICATION;
   ANTIOXIDANT; INDUCTION; GENE; CARBOXYLESTERASE; METABOLISM
AB Endoplasmic reticulum (ER) stress is recognized as a common theme in the development of metabolic syndrome and other diseases. Chronic liver diseases develop ER stress and also show decreased capacity of drug metabolism. The pregnane X receptor (PXR) is a master regulator of genes involved in drug elimination. This study was performed to determine whether ER stress condition decreases the expression of PXR and whether the decrease alters the induction of cytochrome P450 3A4 (CYP3A4). Human primary hepatocytes and HepG2 cell line (human hepatocellular carcinoma) were treated with brefeldin A and thapsigargin, 2 well-established ER stressors. Without exceptions, both stressors significantly decreased the expression of PXR. The decrease led to reduced induction of CYP3A4. Reporter dissection study, electrophoretic mobility shift assay, and chromatin immunoprecipitation located in the PXR promoter region 2 adjacent elements recognized by hepatocyte nuclear factor-4 alpha (HNF-4 alpha) and cytidine-cytidine-adenosine-adenosine-thymidine enhanced binding proteins (C/EBPs), respectively. Additional studies demonstrated that HNF-4 alpha was down-regulated during ER stress but the expression of C/EBP beta varied depending on a particular form of C/EBP beta. Liver-enriched activator protein (LAP) was down-regulated but liver-enriched inhibitory protein (LIP) was highly induced. Nevertheless, over-expression of HNF-4 alpha or LAP restored the expression of PXR. Interestingly, the very same sequence also responded to interleukin-6 (IL-6), and primary hepatocytes treated with thapsigargin significantly increased the level of IL-6 mRNA. These findings establish a functional interconnection between ER stress and signaling of proinflammatory cytokines in the regulation of PXR expression.
C1 [Vachirayonsti, Thaveechai; Ho, Karen W.; Yang, Dongfang; Yan, Bingfang] Univ Rhode Isl, Dept Biomed & Pharmaceut Sci, Ctr Pharmacogen & Mol Therapy, Kingston, RI 02881 USA.
C3 University of Rhode Island
RP Yan, BF (corresponding author), Univ Rhode Isl, Dept Biomed & Pharmaceut Sci, 360 Pharm Bldg,7 Greenhouse Rd, Kingston, RI 02881 USA.
EM byan@uri.edu
RI Yang, Dongfang/A-2413-2013
FU National Institutes of Health [R01GM061988, R01ES007965, R15AT007705]
FX The National Institutes of Health (grants R01GM061988, R01ES007965, and
   R15AT007705 to B.Y.).
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NR 51
TC 15
Z9 22
U1 0
U2 6
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1096-6080
EI 1096-0929
J9 TOXICOL SCI
JI Toxicol. Sci.
PD APR
PY 2015
VL 144
IS 2
BP 382
EP 392
DI 10.1093/toxsci/kfv008
PG 11
WC Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Toxicology
GA CG8FT
UT WOS:000353543400018
PM 25616597
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Yang, Y
   Hayden, MR
   Sowers, S
   Bagree, SV
   Sowers, JR
AF Yang, Ying
   Hayden, Melvin R.
   Sowers, Susan
   Bagree, Sarika V.
   Sowers, James R.
TI Retinal redox stress and remodeling in cardiometabolic syndrome and
   diabetes
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Review
DE retina; redox stress; cardiometabolic syndrome; type 2 diabetes mellitus
ID EPITHELIUM-DERIVED FACTOR; GLYCATION END-PRODUCTS; GROWTH-FACTOR-I;
   METABOLIC SYNDROME; OXIDATIVE STRESS; PLASMA-PROTEIN; ATHEROSCLEROSIS
   RISK; MICROVASCULAR SIGNS; ADIPONECTIN LEVELS; INDUCED APOPTOSIS
AB Diabetic retinopathy (DR) is a significant cause of global blindness; a major cause of blindness in the United States in people aged between 20-74. There is emerging evidence that retinopathy is initiated and propagated by multiple metabolic toxicities associated with excess production of reactive oxygen species (ROS). The four traditional metabolic pathways involved in the development of DR include: increased polyol pathway flux, advanced glycation end-product formation, activation of protein kinase Cisoforms and hexosamine pathway flux. These pathways individually and synergisticallycontribute to redox stress with excess ROS resulting in retinal tissue injury resulting in significant microvascular blood retinal barrier remodeling. The toxicity of hyperinsulinemia, hyperglycemia, hypertension, dyslipidemia, increased cytokines and growth factors, in conjunction with redox stress, contribute to the development and progression of DR. Redox stress contributes to the development and progression of abnormalities of endothelial cells and pericytes in DR. This review focuses on the ultrastructural observations of the blood retinal barrier including the relationship between the endothelial cell and pericyte remodeling in young nine week old Zucker obese (fa/fa) rat model of obesity; cardiometabolic syndrome, and the 20 week old alloxan induced diabetic porcine model. Preventing or delaying the blindness associated with these intersecting abnormal metabolic pathways may be approached through strategies targeted to reduction of tissue inflammation and oxidative redox stress. Understanding these abnormal metabolic pathways and the accompanying redox stress and remodeling mayprovide both the clinician and researcher a new concept of approaching this complicated disease process.
C1 [Hayden, Melvin R.; Bagree, Sarika V.; Sowers, James R.] Univ Missouri, Sch Med, Dept Internal Med, Columbia, MO 65211 USA.
   [Yang, Ying] Yunnan Prov 2nd Hosp, Kunming, Peoples R China.
   [Yang, Ying; Hayden, Melvin R.; Sowers, Susan; Bagree, Sarika V.; Sowers, James R.] Univ Missouri, Sch Med, Div Endocrinol Diabet Metab & Cardiovasc Dis, Columbia, MO 65211 USA.
   [Yang, Ying; Sowers, Susan; Sowers, James R.] Univ Missouri, Sch Med, Harry S Truman VA Med Ctr, Columbia, MO 65211 USA.
C3 University of Missouri System; University of Missouri Columbia;
   University of Missouri System; University of Missouri Columbia; US
   Department of Veterans Affairs; Veterans Health Administration (VHA);
   Harry S. Truman Memorial Veterans' Hospital; University of Missouri
   System; University of Missouri Columbia
RP Hayden, MR (corresponding author), Univ Missouri, Sch Med, Dept Internal Med, Columbia, MO 65211 USA.
EM mrh29@usmo.com
FU National Natural Science Foundation of China [30960148]
FX Authors acknowledge Dr. Martin Katz, Ph.D., director of the electron
   microscopy core facility and Cheryl Jensen (University of Missouri,
   Columbia, Missouri) for preparing retinal tissue samples for study and
   Brenda Hunter for her assistance in preparing this manuscript. Support
   for this research was provided for Y.Y., by a grant from the National
   Natural Science Foundation of China (No 30960148).
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NR 63
TC 45
Z9 52
U1 0
U2 10
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PD NOV-DEC
PY 2010
VL 3
IS 6
BP 392
EP 403
DI 10.4161/oxim.3.6.14786
PG 12
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA 743WI
UT WOS:000289049300004
PM 21307645
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Nourbakhsh, M
   Sharifi, R
   Heydari, N
   Ezzati-Mobasser, S
   Zarrinnahad, H
AF Nourbakhsh, M.
   Sharifi, R.
   Heydari, N.
   Ezzati-Mobasser, S.
   Zarrinnahad, H.
TI Circulating TRB3 and GRP78 levels in type 2 diabetes patients: crosstalk
   between glucose homeostasis and endoplasmic reticulum stress
SO JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
LA English
DT Article
DE Type 2 diabetes mellitus (T2DM); Insulin resistance; TRB3; GRP78;
   Endoplasmic reticulum (ER) stress; Advanced glycated end products (AGEs)
ID FUNCTIONAL Q84R POLYMORPHISM; UNFOLDED PROTEIN RESPONSE; GLYCATION
   END-PRODUCTS; INSULIN-RESISTANCE; ER STRESS; TRIBBLES HOMOLOG; METABOLIC
   SYNDROME; INDUCED APOPTOSIS; INHIBITS INSULIN; OBESE
AB Purpose Endoplasmic reticulum (ER) stress is implicated in the development of type 2 diabetes mellitus (T2DM) and insulin resistance. Tribbles homolog 3 (TRB3) is a pseudokinase upregulated by ER stress and hyperglycemia. Glucose-regulated protein 78 (GRP78) is an ER stress protein that is overexpressed under ER stress conditions. The current study aimed to investigate serum levels of TRB3 and GRP78, as an ER stress marker, in T2DM patients and their correlations with the metabolic profile. Methods Fifty-seven patients with type 2 diabetes and 23 healthy control subjects were evaluated for serum concentrations of TRB3, GRP78, and AGEs by enzyme-linked immunosorbent assay (ELISA). Fasting plasma glucose (FPG), HbA1c, lipid profile, TNF-alpha and insulin were also measured, and insulin resistance was calculated using a homeostasis model assessment of insulin resistance (HOMA-IR). Results Serum concentrations of TRB3, GRP78, AGEs, and TNF-alpha were significantly higher in T2DM patients compared to the healthy controls. Moreover, a statistically significant positive correlation was observed between plasma concentrations of TRB3 and FPG, HbA1c, HOMA-IR, and AGE. GRP78 levels were positively correlated with HbA1c and AGEs. There was also a positive correlation between GRP78 and TRB3. AGEs levels were positively correlated with the levels of FPG, HbA1c, HOMA-IR, and TNF-alpha. Conclusion The current findings suggest that TRB3 and GRP78 may contribute to the pathogenesis of T2DM and might be considered as a therapeutic targets for the treatment of this disease.
C1 [Nourbakhsh, M.; Heydari, N.; Zarrinnahad, H.] Iran Univ Med Sci, Fac Med, Dept Biochem, Tehran, Iran.
   [Nourbakhsh, M.; Ezzati-Mobasser, S.] Univ Tehran Med Sci, Metab Disorders Res Ctr, Endocrinol & Metab Mol Cellular Sci Inst, Tehran, Iran.
   [Sharifi, R.] Iran Univ Med Sci, Sch Allied Med Sci, Dept Med Lab Sci, Tehran 1449614535, Iran.
   [Nourbakhsh, M.] Iran Univ Med Sci, Hazrat Aliasghar Childrens Hosp, Tehran, Iran.
   [Ezzati-Mobasser, S.] Univ Tehran Med Sci, Endocrinol & Metab Res Ctr, Endocrinol & Metab Clin Sci Inst, Tehran, Iran.
C3 Iran University of Medical Sciences; Tehran University of Medical
   Sciences; Iran University of Medical Sciences; Iran University of
   Medical Sciences; Tehran University of Medical Sciences
RP Sharifi, R (corresponding author), Iran Univ Med Sci, Sch Allied Med Sci, Dept Med Lab Sci, Tehran 1449614535, Iran.
EM sharifi.r@iums.ac.ir
RI nourbakhsh, Mona/O-9521-2018; Mobaser, Samira/AAD-2630-2021
OI Heydari, Neda/0000-0001-6121-7957
FU Endocrinology and Metabolism Research Institute, Tehran University of
   Medical Sciences [1396-02-97-2170]; Iran University of Medical Science
   [33203]
FX This study was financially supported by a grant from Endocrinology and
   Metabolism Research Institute, Tehran University of Medical Sciences
   (grant number 1396-02-97-2170) and a grant from Iran University of
   Medical Science (grant number 33203).
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NR 58
TC 21
Z9 25
U1 0
U2 7
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0391-4097
EI 1720-8386
J9 J ENDOCRINOL INVEST
JI J. Endocrinol. Invest.
PD MAR
PY 2022
VL 45
IS 3
BP 649
EP 655
DI 10.1007/s40618-021-01683-5
EA SEP 2021
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA ZB4SU
UT WOS:000702182900002
PM 34591271
DA 2025-06-11
ER

PT J
AU Cho, YE
   Kim, HS
   Lai, C
   Stanfill, A
   Cashion, A
AF Cho, Young-Eun
   Kim, Hyung-Suk
   Lai, Chen
   Stanfill, Ansley
   Cashion, Ann
TI Oxidative stress is associated with weight gain in recipients at
   12-months following kidney transplantation
SO CLINICAL BIOCHEMISTRY
LA English
DT Article
DE Kidney transplantation; Oxidative stress; Weight gain
ID RENAL-TRANSPLANTATION; LIPID-PEROXIDATION; METABOLIC SYNDROME; OBESITY;
   IMPACT; CYCLOSPORINE; PREVALENCE; BIOMARKERS; SURVIVAL; THERAPY
AB Objective: Weight gain after kidney transplantation (Tx) is considered a risk factor for poor outcomes. Increased oxidative stress is associated with not only chronic renal disease and Tx, but also obesity and cardiovascular disease. The aim of this pilot study was to test whether oxidative stress is related to weight gain at 12-months after kidney Tx and to obtain preliminary insight into potential mechanisms involved.
   Design & methods: Recipients (n = 33) were classified into two groups; weight loss and weight gain, based on their weight changes at 12-months post-transplant. Total antioxidant capacity (TAOC) and lipid peroxidation (TBARS) were measured to evaluate oxidative stress from plasma at baseline and 12-months. A secondary data analysis was conducted to identify potential gene regulation.
   Results: Seventeen recipients lost (-6.63 +/- 5.52 kg), and sixteen recipients gained weight (8.94 +/- 6.18 kg). TAOC was significantly decreased at 12-months compared to baseline for the total group, however, there was no significant difference between groups at either time point. TBARS was higher in weight gain group, at both time points, and it was significantly higher at 12-months (p = 0.012). Gene expression profiling analysis showed that 7 transcripts annotated to reactive oxygen species related genes in adipose tissue were expressed significantly lower in weight gain group at baseline, which might be a negative feedback mechanism to reduce oxidative stress.
   Conclusion: These results may indicate that elevated oxidative stress (TBARS) is associated with weight gain after kidney Tx and that incorporating early clinical prevention strategies known to decrease oxidative stress could be recommended. (C) 2015 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
C1 [Cho, Young-Eun; Kim, Hyung-Suk; Lai, Chen; Cashion, Ann] NINR, NIH, 3 Ctr Dr,Bldg 3,Room 5E26, Bethesda, MD 20892 USA.
   [Stanfill, Ansley] Univ Pittsburgh, 440 Victoria Bldg,3500 Victoria St, Pittsburgh, PA 15261 USA.
C3 National Institutes of Health (NIH) - USA; NIH National Institute of
   Nursing Research (NINR); Pennsylvania Commonwealth System of Higher
   Education (PCSHE); University of Pittsburgh
RP Cashion, A (corresponding author), NINR, NIH, 3 Ctr Dr,Bldg 3,Room 5E26, Bethesda, MD 20892 USA.
EM young-eun.cho@nih.gov; kimhy@mail.nih.gov; laichi@mail.nih.gov;
   stanfill@pitt.edu; ann.cashion@nih.gov
OI Stanfill, Ansley/0000-0001-7620-1130
FU National Institute of Nursing Research of the National Institutes of
   Health [R01NR009270]; National Institute of Nursing Research intramural
   funding
FX The authors would like to thank colleagues at the University of
   Tennessee Health Science Center, Memphis, Tennessee for the help in
   patient recruitment, plasma sample collection and genomic data
   management. Research reported in this study was supported by the
   National Institute of Nursing Research of the National Institutes of
   Health under award number R01NR009270, and the National Institute of
   Nursing Research intramural funding.
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NR 39
TC 6
Z9 8
U1 0
U2 8
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0009-9120
EI 1873-2933
J9 CLIN BIOCHEM
JI Clin. Biochem.
PD FEB
PY 2016
VL 49
IS 3
BP 237
EP 242
DI 10.1016/j.clinbiochem.2015.11.002
PG 6
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA DC3XN
UT WOS:000369153100008
PM 26545907
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Chae, WR
   Fuentes-Casañ, M
   Gutknecht, F
   Ljubez, A
   Gold, SM
   Wingenfeld, K
   Otte, C
AF Chae, Woo Ri
   Fuentes-Casan, Manuel
   Gutknecht, Felix
   Ljubez, Angela
   Gold, Stefan M.
   Wingenfeld, Katja
   Otte, Christian
TI Early-onset late-life depression: Association with body mass index,
   obesity, and treatment response
SO COMPREHENSIVE PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE Depressive disorder; Late-life depression; Chart review; Obesity;
   Treatment outcome
ID WHITE-MATTER HYPERINTENSITIES; HIPPOCAMPAL VOLUMES; METABOLIC SYNDROME;
   DISEASE; METAANALYSIS; OVERWEIGHT; MORTALITY; ATROPHY; MRI; AGE
AB Early-onset (EOD) and late-onset (LOD) late-life depression might differ in etiology, clinical features, and treatment response. While EOD is more frequently associated with a family history of affective disorders and personality aspects, LOD is thought to be more strongly driven by acquired cerebrovascular risk factors associated with vascular pathology, executive dysfunction, and poor treatment response. However, in a systematic review, EOD and LOD only differed in the frequency of affective disorders in the family history. We compared EOD versus LOD using medical records. In this retrospective chart review, elderly depressed patients (N = 108; mean age: 69.0 +/- 7.2 years) were characterized by sociodemographic, psychiatric, and somatic variables and divided according to age-at-onset (cut-off: 60 years): EOD (N = 67, mean age-at-onset: 40.2 +/- 13.6 years) and LOD (N = 41, 67.5 +/- 6.3 years). A family history of affective disorders was more common in EOD than LOD patients (49.2% vs. 19.5%). EOD patients had a higher body mass index (mean: 27.0 kg/m2 vs. 23.1 kg/m2) and were more often obese compared with LOD patients (20% vs. 0%). There were fewer treatment responders in the EOD group than in the LOD group on trend level significance (46.3% vs. 63.4%). Higher frequency of affective disorders in the family history is compatible with a greater genetic risk of EOD. The larger metabolic burden of EOD might stem from the longer duration of depressive illness.
C1 [Chae, Woo Ri; Fuentes-Casan, Manuel; Gutknecht, Felix; Ljubez, Angela; Gold, Stefan M.; Wingenfeld, Katja; Otte, Christian] Charite Univ Med Berlin, Hindenburgdamm 30, D-12203 Berlin, Germany.
   [Chae, Woo Ri; Fuentes-Casan, Manuel; Gutknecht, Felix; Ljubez, Angela; Gold, Stefan M.; Wingenfeld, Katja; Otte, Christian] Humboldt Univ, Freie Univ Berlin, Hindenburgdamm 30, D-12203 Berlin, Germany.
   [Chae, Woo Ri; Fuentes-Casan, Manuel; Gutknecht, Felix; Ljubez, Angela; Gold, Stefan M.; Wingenfeld, Katja; Otte, Christian] Berlin Inst Hlth, Dept Psychiat & Psychotherapy, Campus Benjamin Franklin, Hindenburgdamm 30, D-12203 Berlin, Germany.
   [Gold, Stefan M.] Berlin Inst Hlth, Ctr Internal Med & Dermatol, Dept Psychosomat Med, Hindenburgdamm 30, D-12203 Berlin, Germany.
   [Gold, Stefan M.] Univ Med Ctr Hamburg Eppendorf, Inst Neuroimmunol & Multiple Sclerosis INIMS, Ctr Mol Neurobiol, Falkenried 94, D-20251 Hamburg, Germany.
   [Chae, Woo Ri] Charite Univ Med Berlin, Dept Psychiat & Psychotherapy, Campus Benjamin Franklin, Hindenburgdamm 30, D-12203 Berlin, Germany.
C3 Berlin Institute of Health; Free University of Berlin; Humboldt
   University of Berlin; Charite Universitatsmedizin Berlin; Free
   University of Berlin; Humboldt University of Berlin; Berlin Institute of
   Health; Free University of Berlin; Humboldt University of Berlin;
   Charite Universitatsmedizin Berlin; Berlin Institute of Health;
   University of Hamburg; University Medical Center Hamburg-Eppendorf;
   Berlin Institute of Health; Free University of Berlin; Humboldt
   University of Berlin; Charite Universitatsmedizin Berlin
RP Chae, WR (corresponding author), Charite Univ Med Berlin, Dept Psychiat & Psychotherapy, Campus Benjamin Franklin, Hindenburgdamm 30, D-12203 Berlin, Germany.
EM woo-ri.chae@charite.de
RI Chae, Woo Ri/ACZ-9020-2022
OI Otte, Christian/0000-0002-4051-997X; Fuentes Casan,
   Manuel/0000-0002-5830-5267; Gold, Stefan/0000-0001-5188-4799;
   Wingenfeld, Katja/0000-0001-7457-0370; Chae, Woo Ri/0000-0002-6326-8333
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NR 31
TC 4
Z9 4
U1 0
U2 0
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2666-4976
J9 COMPR PSYCHONEUROEND
JI Compr. Psychoneuroendocrinol.
PD NOV
PY 2021
VL 8
AR 100096
DI 10.1016/j.cpnec.2021.100096
PG 6
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA U4GN1
UT WOS:001084399200002
PM 35757669
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Schmieder, A
   Poppe, M
   Hametner, C
   Meyer-Schraml, H
   Schaarschmidt, ML
   Findeisen, P
   Benoit, S
   Bauer, B
   Schmid, S
   Goebeler, M
   Goerdt, S
   Ludwig-Peitsch, WK
AF Schmieder, Astrid
   Poppe, Manuel
   Hametner, Christian
   Meyer-Schraml, Hanna
   Schaarschmidt, Marthe-Lisa
   Findeisen, Peter
   Benoit, Sandrine
   Bauer, Boris
   Schmid, Sybille
   Goebeler, Matthias
   Goerdt, Sergij
   Ludwig-Peitsch, Wiebke K.
TI Impact of fumaric acid esters on cardiovascular risk factors and
   depression in psoriasis: a prospective pilot study
SO ARCHIVES OF DERMATOLOGICAL RESEARCH
LA English
DT Article
DE Psoriasis; Fumaric acid esters; Adiponectin; Cardiovascular disease;
   Depression; Treatment satisfaction
ID CHRONIC PLAQUE PSORIASIS; RHEUMATOID-ARTHRITIS; DIMETHYL FUMARATE;
   MYOCARDIAL-INFARCTION; METABOLIC SYNDROME; IN-VITRO; DISEASE; THERAPY;
   METHOTREXATE; INFLAMMATION
AB Patients with psoriasis have an increased risk of cardiovascular disease that is partly attributable to chronic systemic inflammation. The aim of our prospective pilot study was to investigate the impact of fumaric acid esters (FAE), a first-line systemic antipsoriatic treatment in Germany, on cardiovascular risk parameters. Participants with moderate-to-severe psoriasis from the University Medical Center Mannheim and the University Hospital Wurzburg were treated with FAE for 16 weeks according to standard dosage recommendations. Disease severity, life quality and depression scores as well as biomarkers of inflammation, lipid and glucose metabolism were assessed prior to initiation of FAE and after 16 weeks. Out of 39 participants recruited, 27 completed the study. 44 % of all participants and 63 % of those completing the 16-week treatment achieved PASI 50 response and 27 or 37 % PASI 75 response. Clinical improvement was paralleled by significant improvement in quality of life, high treatment satisfaction and significant reduction of depressive symptoms. Adverse events, most frequently mild gastrointestinal complaints, flush and lymphocytopenia occurred in 89 %. FAE did not modify glucose metabolism or inflammatory parameters substantially. However, a highly significant increase in serum levels of the atheroprotective cytokine adiponectin was noted after 16 weeks (median 4.7 vs. 8.9 A mu g/ml; p = 0.0002). Our study demonstrates a significant beneficial impact of FAE on adiponectin, indicating a potential cardioprotective effect. It will be interesting to verify this finding in larger cohorts and to assess the long-term influence of FAE on cardiovascular risk and disease.
C1 [Schmieder, Astrid; Poppe, Manuel; Meyer-Schraml, Hanna; Schaarschmidt, Marthe-Lisa; Goerdt, Sergij; Ludwig-Peitsch, Wiebke K.] Heidelberg Univ, Univ Med Ctr, Dept Dermatol Venereol & Allergol, D-68135 Mannheim, Germany.
   [Schmieder, Astrid; Poppe, Manuel; Meyer-Schraml, Hanna; Schaarschmidt, Marthe-Lisa; Goerdt, Sergij; Ludwig-Peitsch, Wiebke K.] Heidelberg Univ, Med Fac Mannheim, D-68135 Mannheim, Germany.
   [Hametner, Christian] Heidelberg Univ, Dept Neurol, Heidelberg, Germany.
   [Findeisen, Peter] Heidelberg Univ, Univ Med Ctr Mannheim, Inst Clin Chem, D-68135 Mannheim, Germany.
   [Benoit, Sandrine; Bauer, Boris; Schmid, Sybille; Goebeler, Matthias] Univ Hosp Wurzburg, Dept Dermatol Venereol & Allergol, Wurzburg, Germany.
C3 Ruprecht Karls University Heidelberg; Ruprecht Karls University
   Heidelberg; Ruprecht Karls University Heidelberg; Ruprecht Karls
   University Heidelberg; University of Wurzburg
RP Ludwig-Peitsch, WK (corresponding author), Heidelberg Univ, Univ Med Ctr, Dept Dermatol Venereol & Allergol, Theodor Kutzer Ufer 1-3, D-68135 Mannheim, Germany.
EM wiebke.ludwig@umm.de
RI Schmieder, Astrid/IYS-1367-2023; Goebeler, Matthias/P-3612-2019
FU Olympia Morata grant from the University of Heidelberg; Deutsche
   Forschungsgemeinschaft (DFG) [SFB938]; German network "Health Services
   Research Baden-Wurttemberg" of the Ministry of Science, Research and
   Arts; Ministry of Employment and Social Order, Family, Women and Senior
   Citizens, Baden-Wurttemberg
FX Ms. Anette Oberst (Department of Dermatology, Venerology and
   Allergology, University Medical Center Mannheim) is acknowledged for
   excellent support with data documentation. Furthermore, we thank the
   medical doctors and nursing staff of our psoriasis clinics for help with
   patient recruitment. This work was supported in part by a Olympia Morata
   grant from the University of Heidelberg to AS, by grants of the Deutsche
   Forschungsgemeinschaft (DFG), SFB938, project H to SG, and by the young
   scientists' program of the German network "Health Services Research
   Baden-Wurttemberg" of the Ministry of Science, Research and Arts in
   collaboration with the Ministry of Employment and Social Order, Family,
   Women and Senior Citizens, Baden-Wurttemberg (-grant to MLS).
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NR 48
TC 21
Z9 22
U1 0
U2 9
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0340-3696
EI 1432-069X
J9 ARCH DERMATOL RES
JI Arch. Dermatol. Res.
PD JUL
PY 2015
VL 307
IS 5
BP 413
EP 424
DI 10.1007/s00403-015-1541-7
PG 12
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA CK7BG
UT WOS:000356384200004
PM 25648959
DA 2025-06-11
ER

PT J
AU Katsiardanis, K
   Diamantaras, AA
   Dessypris, N
   Michelakos, T
   Anastasiou, A
   Katsiardani, KP
   Kanavidis, P
   Papadopoulos, FC
   Stefanadis, C
   Panagiotakos, DB
   Petridou, ET
AF Katsiardanis, Konstantinos
   Diamantaras, Andreas-Antonios
   Dessypris, Nick
   Michelakos, Theodoros
   Anastasiou, Anastasia
   Katsiardani, Kalliopi-Penelopi
   Kanavidis, Prodromos
   Papadopoulos, Fotios C.
   Stefanadis, Christodoulos
   Panagiotakos, Demosthenes B.
   Petridou, Eleni T.
TI Cognitive Impairment and Dietary Habits Among Elders: The Velestino
   Study
SO JOURNAL OF MEDICINAL FOOD
LA English
DT Article
DE cognitive impairment; elderly; food groups; mental; nutrients
ID MEDITERRANEAN DIET; RISK-FACTORS; FATTY-ACIDS; OLIVE OIL; DEMENTIA;
   DISEASE; INFLAMMATION; DEPRESSION; ADHERENCE; CONSENSUS
AB To investigate the association of dietary habits with cognitive function among elders (>65 years). Complete sociodemographic, dietary information, serum measurements, and Mini-Mental State Examination (MMSE) assessments were available for 237 elderly men and 320 women residing in Velestino, Greece (a rural Greek town). All models were adjusted for age, education, social activity, smoking, depression symptomatology (using the Geriatric Depression Scale), MedDiet-Score (range 0-55), and metabolic syndrome. About 49.8% men and 66.6% women had MMSE scores <24, with a mean MMSE score of 22.7 +/- 4.43 and 21.1 +/- 4.73, respectively. Adherence to the Mediterranean diet was moderate (mean Med-DietScore of 34.1 +/- 3.25 in men and 35.1 +/- 2.48 in women). Indicative cognitive impairment (MMSE score <24) was positively associated with age and low education in women and with depressive symptoms, low education status, and low social activity in men. Adherence to the Mediterranean diet was positively associated with MMSE score in men (P =.02), but inversely associated in women (P=.04). Concerning the food groups studied, intake of pulses, nuts, and seeds was associated with lower likelihood of having MMSE score <24 in men (P=.04). Only the Mediterranean dietary pattern showed a significant association with MMSE score positive for cognitive impairment (i.e., protective in men, but not in women), while individual food groups or nutrients did not achieve significance. The latter findings support the role of whole diet in the prevention of mental disorders, and state a research hypothesis for a sex-diet interaction on cognitive function among elders.
C1 [Katsiardanis, Konstantinos; Diamantaras, Andreas-Antonios; Dessypris, Nick; Michelakos, Theodoros; Anastasiou, Anastasia; Kanavidis, Prodromos; Papadopoulos, Fotios C.; Petridou, Eleni T.] Univ Athens, Sch Med, Dept Hyg Epidemiol & Med Stat, GR-11527 Athens, Greece.
   [Stefanadis, Christodoulos] Univ Athens, Sch Med, Cardiol Dept Hyg 1, GR-11527 Athens, Greece.
   [Panagiotakos, Demosthenes B.] Harokopio Univ, Dept Nutr & Dietet, Athens, Greece.
C3 National & Kapodistrian University of Athens; Athens Medical School;
   National & Kapodistrian University of Athens; Athens Medical School;
   Harokopio University Athens
RP Diamantaras, AA (corresponding author), Univ Athens, Sch Med, Dept Hyg & Epidemiol, 75 M Asias Str, Athens 11527, Greece.
EM epetrid@med.uoa.gr
RI Michelakos, Theodoros/AAP-7827-2020; Panagiotakos,
   Demosthenes/K-8294-2019; Papadopoulos, Fotios/H-1319-2019; Stefanadis,
   Christodoulos/ABH-2232-2020
OI Kanavidis, Prodromos/0000-0002-2819-472X; PETRIDOU,
   ELENI/0000-0003-3695-3439; Stefanadis,
   Christodoulos/0000-0001-5974-6454; Michelakos,
   Theodoros/0000-0002-4047-0926
CR Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
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NR 38
TC 60
Z9 62
U1 0
U2 44
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1096-620X
EI 1557-7600
J9 J MED FOOD
JI J. Med. Food
PD APR
PY 2013
VL 16
IS 4
BP 343
EP 350
DI 10.1089/jmf.2012.0225
PG 8
WC Chemistry, Medicinal; Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Food Science & Technology; Nutrition &
   Dietetics
GA 122XR
UT WOS:000317352400011
PM 23514229
DA 2025-06-11
ER

PT J
AU Sahoo, PK
   Krishnamoorthy, C
   Wood, JR
   Hanson, C
   Anderson-Berry, A
   Mott, JL
   Natarajan, SK
AF Sahoo, Prakash Kumar
   Krishnamoorthy, Chandan
   Wood, Jennifer R.
   Hanson, Corrine
   Anderson-Berry, Ann
   Mott, Justin L.
   Natarajan, Sathish Kumar
TI Palmitate induces integrated stress response and lipoapoptosis in
   trophoblasts
SO CELL DEATH & DISEASE
LA English
DT Article
ID MATERNAL OBESITY; PLACENTAL FUNCTION; INFLAMMATION; ACTIVATION; HEALTH;
   FOXO3
AB Maternal obesity increases the risk of childhood obesity and programs the offspring to develop metabolic syndrome later in their life. Palmitate is the predominant saturated free fatty acid (FFA) that is transported across the placenta to the fetus. We have recently shown that saturated FFA in the maternal circulation as a result of increased adipose tissue lipolysis in third trimester of pregnancy induces trophoblast lipoapoptosis. Here, we hypothesized that palmitate induces integrated stress response by activating mitogen-activated protein kinases (MAPKs), endoplasmic reticulum (ER) stress and granular stress and lipoapoptosis in trophoblasts. Choriocarcinoma-derived third-trimester placental trophoblast-like cells (JEG-3 and JAR) referred as trophoblasts were exposed to various concentrations of palmitate (PA). Apoptosis was assessed by nuclear morphological changes and caspase 3/7 activity. Immunoblot and immunofluorescence analysis was performed to measure the activation of MAPKs, ER stress and granular stress response pathways. Trophoblasts exposed to pathophysiological concentrations of PA showed a concentration-dependent increase in trophoblast lipoapoptosis. PA induces a caspase-dependent trophoblast lipoapoptosis. Further, PA induces MAPK activation (JNK and ERK) via phosphorylation, and activation of ER stress as evidenced by an increased phosphorylation eIF2 alpha & IRE1 alpha. PA also induces the activation of stress granules formation. Two pro-apoptotic transcriptional mediators of PA-induced trophoblast lipoapoptosis, CHOP and FoxO3 have increased nuclear translocation. Mechanistically, PA-induced JNK is critical for trophoblast lipoapoptosis. However, PA-induced activation of ERK and stress granule formation were shown to be cell survival signals to combat subcellular stress due to PA exposure. In conclusion, PA induces the activation of integrated stress responses, among which small molecule inhibition of JNK demonstrated that activation of JNK is critical for PA-induced trophoblast lipoapoptosis and small molecule activation of stress granule formation significantly prevents PA-induced trophoblast lipoapoptosis.
C1 [Sahoo, Prakash Kumar; Krishnamoorthy, Chandan; Natarajan, Sathish Kumar] Univ Nebraska Lincoln, Dept Nutr & Hlth Sci, Lincoln, NE 68588 USA.
   [Wood, Jennifer R.] Univ Nebraska Lincoln, Dept Anim Sci, Lincoln, NE USA.
   [Hanson, Corrine; Natarajan, Sathish Kumar] Univ Nebraska Med Ctr, Coll Allied Hlth Profess Med Nutr Educ, Omaha, NE 68198 USA.
   [Anderson-Berry, Ann] Univ Nebraska Med Ctr, Dept Pediat, Omaha, NE USA.
   [Mott, Justin L.] Univ Nebraska Med Ctr, Dept Biochem & Mol Biol, Omaha, NE USA.
   [Natarajan, Sathish Kumar] Univ Nebraska Lincoln, Dept Biochem, Lincoln, NE 68588 USA.
C3 University of Nebraska System; University of Nebraska Lincoln;
   University of Nebraska System; University of Nebraska Lincoln;
   University of Nebraska System; University of Nebraska Medical Center;
   University of Nebraska System; University of Nebraska Medical Center;
   University of Nebraska System; University of Nebraska Medical Center;
   University of Nebraska System; University of Nebraska Lincoln
RP Natarajan, SK (corresponding author), Univ Nebraska Lincoln, Dept Nutr & Hlth Sci, Lincoln, NE 68588 USA.; Natarajan, SK (corresponding author), Univ Nebraska Med Ctr, Coll Allied Hlth Profess Med Nutr Educ, Omaha, NE 68198 USA.; Natarajan, SK (corresponding author), Univ Nebraska Lincoln, Dept Biochem, Lincoln, NE 68588 USA.
EM snatarajan2@unl.edu
RI Mott, Justin/IYI-9175-2023; Sahoo, Prakash Kumar/LRC-5352-2024; Wood,
   Jennifer/S-3213-2019
OI Natarajan, Sathish kumar/0000-0001-7491-8592
FU U.S. Department of Health & Human Services | NIH | National Institute of
   General Medical Sciences (NIGMS); UNL
FX We would like to thank Terri Fangman and Dirk Anderson in the microscopy
   core and Flow cytometry Core facility, respectively at the Nebraska
   Center for Biotechnology, UNL.
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NR 34
TC 8
Z9 8
U1 0
U2 4
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 2041-4889
J9 CELL DEATH DIS
JI Cell Death Dis.
PD JAN 11
PY 2024
VL 15
IS 1
AR 31
DI 10.1038/s41419-023-06415-6
PG 12
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA ES7V0
UT WOS:001140990100007
PM 38212315
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Jorgacevic, B
   Vucevic, D
   Samardzic, J
   Mladenovic, D
   Veskovic, M
   Vukicevic, D
   Jesic, R
   Radosavljevic, T
AF Jorgacevic, Bojan
   Vucevic, Danijela
   Samardzic, Janko
   Mladenovic, Dusan
   Veskovic, Milena
   Vukicevic, Dusan
   Jesic, Rada
   Radosavljevic, Tatjana
TI The Effect of CB1 Antagonism on Hepatic Oxidative/Nitrosative Stress and
   Inflammation in Nonalcoholic Fatty Liver Disease
SO CURRENT MEDICINAL CHEMISTRY
LA English
DT Review
DE NAFLD; endocannabinoids; CB receptors; CB1 antagonism;
   oxidative/nitrosative stress; inflammation; endocannabinoid system (ES)
ID CANNABINOID-1 RECEPTOR BLOCKER; ENDOCANNABINOID SYSTEM; ADIPOSE-TISSUE;
   OXIDATIVE STRESS; RISK-FACTORS; ALLOSTERIC MODULATORS; OVERWEIGHT
   PATIENTS; ENERGY HOMEOSTASIS; LIPID-METABOLISM; HIGH-AFFINITY
AB Dysfunction of the endocannabinoid system (ES) has been identified in nonalcoholic fatty liver disease (NAFLD) and associated metabolic disorders. Cannabinoid receptor type 1 (CB1) expression is largely dependent on nutritional status. Thus, individuals suffering from NAFLD and metabolic syndrome (MS) have a significant increase in ES activity. Furthermore, oxidative/nitrosative stress and inflammatory process modulation in the liver are highly influenced by the ES. Numerous experimental studies indicate that oxidative and nitrosative stress in the liver is asso ciated with steatosis and portal inflammation during NAFLD. On the other hand, inflammation itself may also contribute to reactive oxygen species (ROS) production due to Kupffer cell activation and increased nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity. The pathways by which endocannabinoids and their lipid-related mediators modulate oxidative stress and lipid peroxidation represent a significant area of research that could yield novel pharmaceutical strategies for the treatment of NAFLD. Cumulative evidence suggested that the ES, particularly CB1 receptors, may also play a role in inflammation and disease progression toward steatohepatitis. Pharmacological inactivation of CB1 receptors in NAFLD exerts multiple beneficial effects, particularly due to the attenuation of hepatic oxidative/nitrosative stress parameters and significant reduction of proinflammatory cytokine production. However, further investigations regarding precise mechanisms by which CB1 blockade influences the reduction of hepatic oxidative/nitrosative stress and inflammation are required before moving toward the clinical phase of the investigation.
C1 [Jorgacevic, Bojan; Vucevic, Danijela; Mladenovic, Dusan; Veskovic, Milena; Vukicevic, Dusan; Radosavljevic, Tatjana] Univ Belgrade, Fac Med, Inst Pathophysiol Ljubodrag Buba Mihailovi, Belgrade 11000, Serbia.
   [Samardzic, Janko] Univ Belgrade, Fac Med, Inst Pharmacol Clin Pharmacol & Toxicol, Belgrade 11000, Serbia.
   [Jesic, Rada] Clin Ctr Serbia, Inst Digest Dis, Belgrade 11000, Serbia.
C3 University of Belgrade; University of Belgrade; Clinical Centre of
   Serbia
RP Radosavljevic, T (corresponding author), Univ Belgrade, Fac Med, Inst Pathophysiol, Dr Subot 9, Belgrade 11000, Serbia.
EM tatjana.radosavljevic@med.bg.ac.rs
RI Radosavljević, Tatjana/AAE-2792-2020; Veskovic, Milena/U-4519-2019;
   Samardzic, Janko/H-7897-2019
OI Samardzic, Janko/0000-0002-8464-4924; Vukicevic,
   Dusan/0000-0002-2038-7076; Radosavljevic, Tatjana/0000-0002-1701-3313;
   Veskovic, Milena/0000-0002-7505-5466; Mladenovic,
   Dusan/0000-0002-8921-6232
FU Ministry of Education, Science and Technological Development of the
   Republic of Serbia [175015]
FX This paper has been financially supported by the Ministry of Education,
   Science and Technological Development of the Republic of Serbia, under
   the Grant No. 175015.
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NR 73
TC 18
Z9 20
U1 0
U2 9
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 0929-8673
EI 1875-533X
J9 CURR MED CHEM
JI Curr. Med. Chem.
PY 2021
VL 28
IS 1
BP 169
EP 180
DI 10.2174/0929867327666200303122734
PG 12
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Pharmacology &
   Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
GA QC1RB
UT WOS:000614610300011
PM 32124686
DA 2025-06-11
ER

PT J
AU Weigensberg, MJ
   Lane, CJ
   Winners, O
   Wright, T
   Nguyen-Rodriguez, S
   Goran, MI
   Spruijt-Metz, D
AF Weigensberg, Marc J.
   Lane, Christianne Joy
   Winners, Oscar
   Wright, Thomas
   Nguyen-Rodriguez, Selena
   Goran, Michael I.
   Spruijt-Metz, Donna
TI Acute Effects of Stress-Reduction Interactive Guided
   Imagery<SUP>SM</SUP> on Salivary Cortisol in Overweight Latino
   Adolescents
SO JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE
LA English
DT Article
ID PITUITARY-ADRENAL AXIS; BETA-CELL FUNCTION; METABOLIC SYNDROME; PUBERTAL
   CHANGES; OBESITY; SECRETION; CHILDREN; FAT; NEUROENDOCRINE; RELAXATION
AB Objectives: Chronic stress with relative hypercortisolism has been associated with metabolic disease risk. Stress-reduction interventions may therefore hold promise for reducing such chronic disease risk in obese youth. The purpose of this study was to conduct a 4-week pilot intervention to determine whether stress-reduction Interactive Guided Imagery(SM) (IGI) could serve as an acceptable and effective stress-reduction modality in overweight Latino adolescents.
   Design: Subjects (6 male/6 female, ages 14-17, body-mass index > 95th percentile) were randomly assigned to the experimental guided imagery group (IGI, n = 6), or the nonintervention control group (C, n = 6). IGI subjects received four weekly 45-minute stress-reduction IGI sessions. Salivary cortisol was assessed immediately before and after each session. Acceptability was assessed by compliance and qualitative interviews.
   Results: Subjects attended all sessions and expressed acceptance of the IGI intervention. There were significant within-group reductions in salivary cortisol in the IGI group in three of the four sessions, and no reductions in cortisol in the control group. For all four sessions combined, there was a significant between-group effect for the change in salivary cortisol in IGI versus C (p = 0.007). Effect sizes of cortisol change in IGI group were moderate to very high in the four sessions.
   Conclusions: We conclude that IGI may be feasible and effective in acutely reducing salivary cortisol levels in overweight Latino adolescents. Future studies will need to determine whether stress-reduction IGI can result in longer-term reductions in chronic stress and measures of HPA activity.
C1 [Weigensberg, Marc J.] Univ So Calif, Keck Sch Med, Dept Pediat, Los Angeles, CA 90033 USA.
   [Lane, Christianne Joy; Winners, Oscar; Nguyen-Rodriguez, Selena; Goran, Michael I.; Spruijt-Metz, Donna] Univ So Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90033 USA.
   [Wright, Thomas] Univ So Calif, Keck Sch Med, Dept Med, Los Angeles, CA 90033 USA.
   [Goran, Michael I.] Univ So Calif, Keck Sch Med, Dept Physiol & Biophys, Los Angeles, CA 90033 USA.
C3 University of Southern California; University of Southern California;
   University of Southern California; University of Southern California
RP Weigensberg, MJ (corresponding author), Univ So Calif, Keck Sch Med, Dept Pediat, 2250 Alcazar St,Suite 211, Los Angeles, CA 90033 USA.
EM weigensb@usc.edu
FU National Center for Research Resources/ National Institutes for Health (
   NCRR/ NIH) [5 M01 RR00043-46]
FX This study was supported by grant 5 M01 RR00043-46 from National Center
   for Research Resources/ National Institutes for Health ( NCRR/ NIH).
   NCRR had no further role in study design, execution of study, analyses,
   or manuscript preparation. We would like to thank the GCRC nursing staff
   for their help. Finally, we would like to acknowledge and thank the
   study subjects and their families for their participation.
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NR 39
TC 17
Z9 28
U1 0
U2 14
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1075-5535
EI 1557-7708
J9 J ALTERN COMPLEM MED
JI J. Altern. Complement Med.
PD MAR
PY 2009
VL 15
IS 3
BP 297
EP 303
DI 10.1089/acm.2008.0156
PG 7
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA 420IQ
UT WOS:000264283000017
PM 19250005
OA Green Published, Green Accepted
DA 2025-06-11
ER

PT J
AU Sinha, R
AF Sinha, Rajita
TI Role of addiction and stress neurobiology on food intake and obesity
SO BIOLOGICAL PSYCHOLOGY
LA English
DT Article
DE Addiction; Stress; Neurobiology; Food intake; Obesity
ID PITUITARY-ADRENAL AXIS; BINGE-EATING DISORDER; BODY-MASS INDEX;
   METABOLIC SYNDROME; SUBSTANCE-USE; SELF-CONTROL; PSYCHOSOCIAL STRESS;
   INSULIN-RESISTANCE; ABDOMINAL OBESITY; NERVOUS-SYSTEM
AB The US remains at the forefront of a global obesity epidemic with a significant negative impact on public health. While it is well known that a balance between energy intake and expenditure is homeostatically regulated to control weight, growing evidence points to multifactorial social, neurobehavioral and metabolic determinants of food intake that influence obesity risk. This review presents factors such as the ubiquitous presence of rewarding foods in the environment and increased salience of such foods that stimulate brain reward motivation and stress circuits to influence eating behaviors. These rewarding foods via conditioned and reinforcing effects stimulate not only metabolic, but also stress hormones, that, in turn, hijack the brain emotional (limbic) and motivational (striatal) pathways, to promote food craving and excessive food intake. Furthermore, the impact of high levels of stress and trauma and altered metabolic environment (e.g. higher weight, altered insulin sensitivity) on prefrontal cortical self-control processes that regulate emotional, motivational and visceral homeostatic mechanisms of food intake and obesity risk are also discussed. A heuristic framework is presented in which the interactive dynamic effects of neurobehavioral adaptations in metabolic, motivation and stress neurobiology may further support food craving, excessive food intake and weight gain in a complex feed-forward manner. Implications of such adaptations in brain addictive-motivational and stress pathways and their effects on excessive food intake and weight gain are discussed to highlight key questions that requires future research attention in order to better understand and address the growing obesity epidemic.
C1 [Sinha, Rajita] Yale Univ, Sch Med, Dept Psychiat, Yale Stress Ctr, 2 Church St South,Suite 209, New Haven, CT 06519 USA.
   [Sinha, Rajita] Yale Univ, Sch Med, Dept Neurosci, New Haven, CT 06520 USA.
C3 Yale University; Yale University
RP Sinha, R (corresponding author), Yale Stress Ctr, 2 Church St South,Suite 209, New Haven, CT 06519 USA.
EM rajita.sinha@yale.edu
OI SINHA, RAJITA/0000-0003-3012-4349
FU National Institute of Diabetes and Digestive and Kidney
   Diseases/National Institutes of Health [R01-DK099039]; National
   Institutes of Health Roadmap for Medical Research Common FundGrants
   [UL1-DE019586, UL1-RR024139, PL1-DA024859]
FX This work was supported by National Institute of Diabetes and Digestive
   and Kidney Diseases/National Institutes of Health grant R01-DK099039 and
   the National Institutes of Health Roadmap for Medical Research Common
   FundGrants UL1-DE019586, UL1-RR024139 (Yale Clinical and Translational
   Science Award), and the PL1-DA024859. Dr. Sinha is on the Scientific
   Advisory Board for Embera Neurotherapeutics.
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NR 150
TC 116
Z9 128
U1 6
U2 69
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0301-0511
EI 1873-6246
J9 BIOL PSYCHOL
JI Biol. Psychol.
PD JAN
PY 2018
VL 131
SI SI
BP 5
EP 13
DI 10.1016/j.biopsycho.2017.05.001
PG 9
WC Psychology, Biological; Behavioral Sciences; Psychology; Psychology,
   Experimental
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Behavioral Sciences
GA FW1VJ
UT WOS:000425087900002
PM 28479142
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Ivic, V
   Blazetic, S
   Labak, I
   Balog, M
   Vondrak, L
   Blazekovic, R
   Vari, SG
   Heffer, M
AF Ivic, Vedrana
   Blazetic, Senka
   Labak, Irena
   Balog, Marta
   Vondrak, Luka
   Blazekovic, Robert
   Vari, Sandor G.
   Heffer, Marija
TI Ovariectomy and chronic stress lead toward leptin resistance in the
   satiety centers and insulin resistance in the hippocampus of
   Sprague-Dawley rats
SO CROATIAN MEDICAL JOURNAL
LA English
DT Article
ID PITUITARY-ADRENAL AXIS; SEX-DIFFERENCES; PSYCHOSOCIAL STRESS; METABOLIC
   SYNDROME; BRAIN; RECEPTORS; RESPONSES; HORMONE; PROGESTERONE; ANDROGEN
AB Aim To evaluate the changes in the expression level of gonadal steroid, insulin, and leptin receptors in the brain of adult Sprague-Dawley female rats due to ovariectomy and/or chronic stress.
   Methods Sixteen-week-old ovariectomized and non-ovariectomized female Sprague-Dawley rats were divided in two groups and exposed to three 10-day-sessions of sham or chronic stress. After the last stress-session the brains were collected and free-floating immunohistochemical staining was performed using androgen (AR), progesterone (PR), estrogen-beta (ER-beta), insulin (IR-alpha), and leptin receptor (ObR) antibodies. The level of receptors expression was analyzed in hypothalamic (HTH), cortical (CTX), dopaminergic (VTA/SNC), and hippocampal regions (HIPP).
   Results Ovariectomy downregulated AR in the hypothalamic satiety centers and hippocampus. It prevented or attenuated the stress-specific up-regulation of AR in these regions. The main difference in stress response between non-ovariectomized and ovariectomized females was in PR level. Ovariectomized ones had increased PR level in the HTH, VTA, and HIPP. Combination of stressors pushed the hypothalamic satiety centers toward the rise of ObR and susceptibility to leptin resistance. When exposed to combined stressors, the HIPP, SNC and piriform cortex upregulated the expression of IR-alpha and the possibility to develop insulin resistance.
   Conclusion Ovariectomy exacerbates the effect of chronic stress by preventing gonadal receptor-specific stress response reflected in the up-regulation of AR in the satiety and hippocampal regions, while stress after ovariectomy usually raises PR. The final outcome of inadequate stress response is reflected in the up-regulation of ObR in the satiety centers and IR-alpha in the regions susceptible to early neurodegeneration. We discussed the possibility of stress induced metabolic changes under conditions of hormone deprivation.
C1 [Ivic, Vedrana; Balog, Marta; Heffer, Marija] Josip Juraj Strossmayer Univ Osijek, Fac Med Osijek, Dept Med Biol & Genet, Cara Hadrijana 10-E, HR-31000 Osijek, Croatia.
   [Blazetic, Senka; Labak, Irena; Vondrak, Luka] Josip Juraj Strossmayer Univ Osijek, Dept Biol, HR-31000 Osijek, Croatia.
   [Blazekovic, Robert] Univ Hosp Dubrava, Dept Cardiac & Transplantat Surg, Zagreb, Croatia.
   [Blazekovic, Robert] Josip Juraj Strossmayer Univ Osijek, Fac Med Osijek, Dept Surg & Neurosurg, HR-31000 Osijek, Croatia.
   [Vari, Sandor G.] Cedars Sinai Med Ctr, Int Res & Innovat Med Program, Los Angeles, CA 90048 USA.
C3 University of JJ Strossmayer Osijek; University of JJ Strossmayer
   Osijek; University of JJ Strossmayer Osijek; Cedars Sinai Medical Center
RP Heffer, M (corresponding author), Josip Juraj Strossmayer Univ Osijek, Fac Med Osijek, Dept Med Biol & Genet, Cara Hadrijana 10-E, HR-31000 Osijek, Croatia.
EM mheffer@mefos.hr
RI Blažeković, Robert/HGD-3467-2022; Heffer, Marija/ABA-4694-2020; Ivić,
   Vedrana/GRS-4202-2022
OI Ivic, Vedrana/0000-0002-8185-1960; Vari, MD, Sandor
   George/0000-0003-2962-2017; Heffer, Marija/0000-0001-6770-7359;
   Blazekovic, Robert/0000-0001-7125-361X
FU Croatian Science Foundation [IP-09-2014-2324]; Faculty of Medicine of
   Josip Juraj Strossmayer University of Osijek [VIF2015-MEFOS-1]
FX Funding The study has been funded in part by the Croatian Science
   Foundation under project number IP-09-2014-2324 and internal research
   grant from Faculty of Medicine of Josip Juraj Strossmayer University of
   Osijek (VIF2015-MEFOS-1).
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NR 38
TC 7
Z9 7
U1 0
U2 18
PU MEDICINSKA NAKLADA
PI ZAGREB
PA VLASKA 69, HR-10000 ZAGREB, CROATIA
SN 0353-9504
EI 1332-8166
J9 CROAT MED J
JI Croat. Med. J.
PD APR
PY 2016
VL 57
IS 2
BP 194
EP 206
DI 10.3325/cmj.2016.57.194
PG 13
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA DN4QX
UT WOS:000377053400011
PM 27106360
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Xu, MX
   Ge, CX
   Qin, YT
   Gu, TT
   Lou, DS
   Li, Q
   Hu, LF
   Feng, J
   Huang, P
   Tan, J
AF Xu, Min-Xuan
   Ge, Chen-Xu
   Qin, Yu-Ting
   Gu, Ting-Ting
   Lou, De-Shuai
   Li, Qiang
   Hu, Lin-Feng
   Feng, Jing
   Huang, Ping
   Tan, Jun
TI Prolonged PM2.5 exposure elevates risk of oxidative stress-driven
   nonalcoholic fatty liver disease by triggering increase of dyslipidemia
SO FREE RADICAL BIOLOGY AND MEDICINE
LA English
DT Article
DE Particular matter 2.5 (PM2.5); Nonalcoholic fatty liver disease (NAFLD);
   Dyslipidemia; Lipid accumulation; Chronic liver injury
ID INSULIN-RESISTANCE; INFLAMMATION; PATHWAY; MODEL
AB An increasing number of studies have shown that air pollution containing particulate matter (PM) = 2.5 mu m (PM2.5) plays a significant role in the development of metabolic disorder and other chronic diseases. Inflammation and oxidative stress caused by metabolic syndrome are widely determined to be critical factors in the development of nonalcoholic fatty liver disease (NAFLD) pathogenesis. However, there is no direct evidence of this, and the underlying molecular mechanism is still not fully understood. In this study, we investigated the role of inflammation and oxidative stress caused by prolonged PM2.5 exposure in dyslipidemia-associated chronic hepatic injury, and further determined whether an increase in hepatic inflammation and oxidative stress promoted lipid accumulation in the liver, ultimately increasing the risk of NAFLD. Therefore, we studied changes in indicators of metabolic disorder and in symbolic indices of NAFLD. We confirmed increases in insulin resistance, glucose tolerance, peripheral inflammation and dysarteriotony in PM2.5-induced mice. Oxidative stress and inflammatory response in the liver caused by PM2.5 inhalation contributed to abnormal hepatic function, further promoting lipid accumulation in the liver. Moreover, we observed inhibition of oxidative stress and inflammatory response by pyrrolidine dithiocarbamate (PDTC) and N-acetyl-L-cysteine (NAC) in vitro, suggesting that oxidative stress and inflammatory in liver cells aggravated by PM2.5 contributed to hepatic injury by altering normal lipid metabolism. These results indicate a new goal for preventing and treating air pollution-induced diseases: suppression of oxidative stress and inflammatory response.
C1 [Xu, Min-Xuan; Ge, Chen-Xu; Lou, De-Shuai; Li, Qiang; Hu, Lin-Feng; Feng, Jing; Tan, Jun] Chongqing Univ Educ, Sch Biol & Chem Engn, Chongqing Key Lab Med Resources Three Gorges Rese, Chongqing 400067, Peoples R China.
   [Qin, Yu-Ting] Ocean Univ China, Sch Med & Pharm, Qingdao 266100, Peoples R China.
   [Xu, Min-Xuan; Ge, Chen-Xu; Lou, De-Shuai; Li, Qiang; Hu, Lin-Feng; Tan, Jun] Chongqing Univ Educ, Res Ctr Brain Intellectual Promot & Dev Children, Chongqing 400067, Peoples R China.
   [Gu, Ting-Ting] Nanjing Univ, Coll Engn & Appl Sci, Nanjing 210023, Jiangsu, Peoples R China.
   [Huang, Ping] Chongqing Med Univ, Dept Hepatobiliary Surg, Affiliated Hosp 1, Chongqing 400000, Peoples R China.
C3 Chongqing University of Education; Ocean University of China; Chongqing
   University of Education; Nanjing University; Chongqing Medical
   University
RP Xu, MX; Tan, J (corresponding author), Chongqing Univ Educ, Sch Biol & Chem Engn, Chongqing Key Lab Med Resources Three Gorges Rese, Chongqing 400067, Peoples R China.
EM minxuanxu@foxmail.com; tanjunmail@126.com
RI hu, linfeng/C-6491-2014
OI Xu, Minxuan/0000-0002-0742-4717
FU National Natural Science Foundation of China (NSFC) [81703527];
   Chongqing Research Program of Basic Research and Frontier Technology
   [cstc2017jcyjAX0356, cstc2018jcyjA3686, cstc2018jcyjA1472,
   cstc2018jcyjA3533]; 2018 Chongqing College Students' Innovation and
   Entrepreneurship Training Project [201814388021, 201814388022];
   School-level Research Program of Chongqing University of Education
   [KY201710B, 17GZKP01]; Advanced Programs of Post-doctor of Chongqing
   [2017LY39]; Fundamental Research Funds for the Central Universities
   [021314380120]
FX This work was supported by National Natural Science Foundation of China
   (NSFC Grant number: 81703527); Chongqing Research Program of Basic
   Research and Frontier Technology (Grant number: cstc2017jcyjAX0356,
   cstc2018jcyjA3686, cstc2018jcyjA1472 and cstc2018jcyjA3533); 2018
   Chongqing College Students' Innovation and Entrepreneurship Training
   Project (Grant number: 201814388021 and 201814388022); School-level
   Research Program of Chongqing University of Education (Grant number:
   KY201710B and 17GZKP01); Advanced Programs of Post-doctor of Chongqing
   (Grant number: 2017LY39) and Fundamental Research Funds for the Central
   Universities (Grant number: 021314380120).
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NR 34
TC 182
Z9 192
U1 2
U2 96
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0891-5849
EI 1873-4596
J9 FREE RADICAL BIO MED
JI Free Radic. Biol. Med.
PD JAN
PY 2019
VL 130
BP 542
EP 556
DI 10.1016/j.freeradbiomed.2018.11.016
PG 15
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA HG9RR
UT WOS:000455347000049
PM 30465824
DA 2025-06-11
ER

PT J
AU Anderson, EK
   Hill, AA
   Hasty, AH
AF Anderson, Emily K.
   Hill, Andrea A.
   Hasty, Alyssa H.
TI Stearic Acid Accumulation in Macrophages Induces Toll-Like Receptor
   4/2-Independent Inflammation Leading to Endoplasmic Reticulum
   Stress-Mediated Apoptosis
SO ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
LA English
DT Article
DE apoptosis; endoplasmic reticulum stress; inflammation; macrophage;
   stearic acid
ID UNFOLDED PROTEIN RESPONSE; FREE FATTY-ACIDS; ADIPOSE-TISSUE; CHEMICAL
   CHAPERONES; INSULIN-RESISTANCE; METABOLIC SYNDROME; CELL-DEATH; ER
   STRESS; C-SRC; OBESITY
AB Objective-Elevated serum free fatty acid levels are associated with an increased risk of cardiovascular disease and type 2 diabetes mellitus. Macrophages are recruited to atherosclerotic plaques and metabolic tissues during obesity and accumulate lipids, including free fatty acids. We investigated the molecular consequences of intracellular saturated free fatty acid accumulation in macrophages.
   Methods and Results-Previously, we demonstrated that cotreatment of mouse peritoneal macrophages (MPMs) with stearic acid and triacsin C (an inhibitor of long-chain acyl coenzyme A synthetases) results in intracellular free fatty acid accumulation and apoptosis. Here, we used Western blotting analysis, real-time reverse transcription polymerase chain reaction, and terminal deoxynucleotidyl transferase dUTP nick-end labeling staining to assess endoplasmic reticulum (ER) stress, inflammation, and apoptosis in MPMs. Intracellular stearic acid accumulation induces Toll-like receptor 4/2-independent inflammation that results in ER stress-mediated apoptosis of MPMs. Polarization of MPMs to a proinflammatory M1 phenotype increases their susceptibility to inflammation and ER stress, but not apoptosis, in response to cotreatment with stearic acid and triacsin C.
   Conclusion-Intracellular accumulation of stearic acid in MPMs activates inflammatory signaling, leading to ER stress-mediated apoptosis. M1 macrophages are more prone to stearic acid-induced inflammation and ER stress. These same pathways may be activated in macrophages residing in atherosclerotic plaques and metabolic tissues during conditions of obesity and hyperlipidemia. (Arterioscler Thromb Vasc Biol 2012;32:1687-1695.)
C1 [Anderson, Emily K.; Hill, Andrea A.; Hasty, Alyssa H.] Vanderbilt Univ, Sch Med, Dept Mol Physiol & Biophys, Nashville, TN 37232 USA.
C3 Vanderbilt University
RP Hasty, AH (corresponding author), Vanderbilt Univ, Sch Med, Dept Mol Physiol & Biophys, 702 Light Hall, Nashville, TN 37232 USA.
EM alyssa.hasty@vanderbilt.edu
RI Hasty, Alyssa/AAA-2757-2020
OI Hasty, Alyssa/0000-0001-7302-8045; McAlester, Andrea/0000-0002-7405-5915
FU National Institutes of Health (NIH) [HL089466]; American Diabetes
   Association [1-07-CD-10]; NIH [T32GM008554]; Cardiovascular Research
   Training Program [T32 HL007411-30]; Vanderbilt Cell Imaging Shared
   Resources Core (NIH) [CA68485, DK20593, DK58404, HD15052, DK59637,
   EY08126]
FX This project was funded by National Institutes of Health (NIH) grant
   HL089466. A.H. Hasty was supported by an American Diabetes Association
   Career Development Award (1-07-CD-10). E.K. Anderson was supported by
   the Cellular, Biochemical, and Molecular Sciences Training Program (NIH
   T32GM008554). A.A. Hill is supported by the Cardiovascular Research
   Training Program (T32 HL007411-30). Imaging experiments were performed
   in the Vanderbilt Cell Imaging Shared Resources Core (NIH grants
   CA68485, DK20593, DK58404, HD15052, DK59637, and EY08126).
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NR 39
TC 92
Z9 103
U1 0
U2 15
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1079-5642
J9 ARTERIOSCL THROM VAS
JI Arterioscler. Thromb. Vasc. Biol.
PD JUL
PY 2012
VL 32
IS 7
BP 1687
EP 1695
DI 10.1161/ATVBAHA.112.250142
PG 9
WC Hematology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Hematology; Cardiovascular System & Cardiology
GA 959SK
UT WOS:000305333100020
PM 22556332
OA Bronze, Green Accepted
DA 2025-06-11
ER

PT J
AU Monk, NJ
   Cunningham, R
   Stanley, J
   Fitzjohn, J
   Kerdemelidis, M
   Lockett, H
   Mclachlan, AD
   Porter, RJ
   Waitoki, W
   Lacey, C
AF Monk, Nathan J.
   Cunningham, Ruth
   Stanley, James
   Fitzjohn, Julie
   Kerdemelidis, Melissa
   Lockett, Helen
   Mclachlan, Andre D.
   Porter, Richard J.
   Waitoki, Waikaremoana
   Lacey, Cameron
TI Inequity in cardiometabolic hospital admissions and blood screening in
   New Zealand Indigenous Māori with psychosis
SO BJPSYCH OPEN
LA English
DT Article
DE Psychosis; indigenous health; health equity; cardiometabolic health;
   blood screening
ID YOUNG-PEOPLE; FOLLOW-UP; MORTALITY; HEALTH; SCHIZOPHRENIA; METAANALYSIS;
   DISORDERS; DISEASE; RISK
AB Background People with psychosis experience worse cardiometabolic health than the same-aged general population. In New Zealand, Indigenous M & amacr;ori experiencing psychosis have greater risk of cardiometabolic and other physical health problems.Aims To identify a cohort of adults accessing secondary mental health and addiction services in New Zealand, with a previous psychosis diagnosis as of 1 January 2018, and compare odds of hospital admission outcomes, mortality and receipt of cardiometabolic blood screening between M & amacr;ori and non-M & amacr;ori in the following 2 years.Method Crude and adjusted logistic regression models compared odds of hospital admission outcomes, mortality and receipt of cardiometabolic blood screening (lipids and haemoglobin A1c) between M & amacr;ori and non-M & amacr;ori, occurring between 1 January 2018 and 31 December 2019.Results A cohort (N = 21 214) of M & amacr;ori (n = 7274) and non-M & amacr;ori (n = 13 940) was identified. M & amacr;ori had higher adjusted risk of mortality (odds ratio 1.26, 95% CI 1.03-1.54), and hospital admission with diabetes (odds ratio 1.64, 95% CI 1.43-1.87), cardiovascular disease (odds ratio 1.54, 95% CI 1.25-1.88) and any physical health condition (odds ratio 1.07, 95% CI 1.00-1.15) than non-M & amacr;ori. Around a third of people did not receive recommended cardiometabolic blood screening, with no difference between M & amacr;ori and non-M & amacr;ori after covariate adjustment.Conclusions M & amacr;ori experiencing psychosis are more likely to die and be admitted to hospital with cardiovascular disease or diabetes than non-M & amacr;ori. Because of the higher cardiometabolic risk borne by M & amacr;ori, it is suggested that cardiometabolic screening shortfalls will lead to worsening physical health inequities for M & amacr;ori experiencing psychosis.
C1 [Monk, Nathan J.] Univ Otago, Dept Maori Indigenous Hlth Innovat, Christchurch, New Zealand.
   [Cunningham, Ruth; Stanley, James] Univ Otago, Dept Publ Hlth, Wellington, New Zealand.
   [Fitzjohn, Julie; Porter, Richard J.] Te Whatu Ora Hlth New Zealand Waitaha, Specialist Mental Hlth Serv, Canterbury, New Zealand.
   [Kerdemelidis, Melissa] Te Whatu Ora Hlth New Zealand Waitaha, Serv Improvement & Innovat, Populat Hlth Gain, Canterbury, New Zealand.
   [Lockett, Helen] Univ Otago, Dept Publ Hlth, Wellington, New Zealand.
   [Lockett, Helen] Te Pou, Auckland, New Zealand.
   [Mclachlan, Andre D.] Waikato Inst Technol, Ctr Hlth & Social Practice, Hamilton, New Zealand.
   [Porter, Richard J.; Lacey, Cameron] Univ Otago, Dept Psychol Med, Christchurch, New Zealand.
   [Waitoki, Waikaremoana] Univ Waikato, Fac Maori & Indigenous Studies, Hamilton, New Zealand.
C3 University of Otago; University of Otago; University of Otago; Waikato
   Institute of Technology; University of Otago; University of Waikato
RP Monk, NJ (corresponding author), Univ Otago, Dept Maori Indigenous Hlth Innovat, Christchurch, New Zealand.
EM nathan.monk@otago.ac.nz
RI Lacey, Cameron/AAF-9180-2020; Monk, Nathan/HTL-7254-2023
OI Monk, Nathan/0000-0002-8932-7434; Cunningham, Ruth/0000-0003-0090-3579;
   Lacey, Cameron/0000-0001-9898-6784
FU Health Research Council of New Zealand [21/558]
FX This study is from Phase 1 of Te Pu Korokoro, funded by the Health
   Research Council of New Zealand (grant number 21/558). The Health
   Research Council had no influence on the study.
CR Armitage R., 2023, BJGPLife
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NR 50
TC 0
Z9 0
U1 0
U2 0
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 2056-4724
J9 BJPSYCH OPEN
JI BJPsych Open
PD SEP 24
PY 2024
VL 10
IS 5
AR e159
DI 10.1192/bjo.2024.759
PG 9
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA G9V4J
UT WOS:001320026900001
PM 39314152
OA gold
DA 2025-06-11
ER

PT J
AU Sun, DL
   Yang, TM
   Wang, M
   Pang, JX
   Li, FM
AF Sun, Dali
   Yang, Tianming
   Wang, Min
   Pang, Junxiao
   Li, Fumin
TI Sub-chronic exposure of hexaconazole may induce metabolic and
   neuropathic diseases: The evidence from gut microbiota
SO PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
LA English
DT Article
DE Hexaconazole; Intestinal dysfunction; Gut microbiota; Metabolic
   diseases; Neuropathic diseases
ID CHAIN FATTY-ACID; DYSBIOSIS; PATHWAY; INJURY; RAT
AB The high-frequency detection and long persistence of hexaconazole (Hex) in agricultural products and environment poses potential risk to non-targeted organisms which should pay special attention to. Intestinal flora plays an important role in host health by prevention the occurrence of various diseases. Therefore, in this study, the disturbance of Hex on intestinal function and flora in rats had been studied at environmental related concentrations to evaluate the potential risk of Hex. Our results showed that Hex exposure induced serious oxidative stress and inflammation in intestinal tract. Meanwhile, it notably decreased the tight connectivity in colonic cell leading to the dysfunction of intestinal barrier. Moreover, 16sRNA gene sequencing showed that Hex exposure significantly disturbed the composition and structures of gut microbiota by decrease beneficial bacteria and increase pathogenic bacteria. Further, the metabolites and SCFAs that related to neuropathic and metabolic diseases in colonic contents were also significantly affected by Hex exposure. The pathways of membrane transport, replication and repair, lipid metabolism, and neurodegenerative diseases had been seriously interfered. The obtained results referred that Hex exposure may pose potential risk to metabolic system causing obesity, metabolic syndrome, and cardiovascular as well as nervous system inducing Parkinson's diseases, Alzheimer's diseases, and depression. Our study provided a new sight to study the mechanisms of Hex induced toxicity effects from the aspect of gut microbiota which could help for prevention the risk induced by Hex.
C1 [Sun, Dali; Yang, Tianming; Wang, Min; Li, Fumin] Guizhou Med Univ, Sch Publ Hlth, Key Lab Environm Pollut Monitoring & Dis Control, Minist Educ, Guiyang 561113, Peoples R China.
   [Pang, Junxiao] Guiyang Univ, Coll Food Sci & Engn, Guiyang 550005, Peoples R China.
C3 Ministry of Education - China; Guizhou Medical University; Guiyang
   University
RP Sun, DL (corresponding author), Guizhou Med Univ, Sch Publ Hlth, Key Lab Environm Pollut Monitoring & Dis Control, Minist Educ, Guiyang 561113, Peoples R China.
EM dalisun11@163.com
RI Li, Fumin/AAZ-2526-2020
FU National Natural Science Foundation of China [22266011]; Guizhou
   Provincial Basic Research Program (Natural Science) [[2023] 289];
   Central government supports the reform and development of local colleges
   and universities [[2023] 067]; Guizhou provincial foundation for
   excellent scholars' program [GCC [2023] 076]
FX This project is supported by the National Natural Science Foundation of
   China (22266011) , Guizhou Provincial Basic Research Program (Natural
   Science) ( [2023] 289) , the Central government supports the reform and
   development of local colleges and universities ( [2023] 067) , and
   Guizhou provincial foundation for excellent scholars' program (GCC
   [2023] 076) .
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NR 73
TC 0
Z9 0
U1 0
U2 0
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0048-3575
EI 1095-9939
J9 PESTIC BIOCHEM PHYS
JI Pest. Biochem. Physiol.
PD MAY
PY 2025
VL 210
AR 106398
DI 10.1016/j.pestbp.2025.106398
PG 13
WC Biochemistry & Molecular Biology; Entomology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Entomology; Physiology
GA 2GZ1P
UT WOS:001482423400001
PM 40262859
DA 2025-06-11
ER

PT J
AU Prasad, K
   Khan, AS
   Bhanumathy, KK
AF Prasad, Kailash
   Khan, Amal S.
   Bhanumathy, Kalpana K.
TI Does AGE-RAGE Stress Play a Role in the Development of Coronary Artery
   Disease in Obesity?
SO INTERNATIONAL JOURNAL OF ANGIOLOGY
LA English
DT Review
DE advanced glycation end products; receptor for AGE; soluble receptor for
   AGE; atherosclerosis; atherogenic factors; AGE-RAGE stress; obesity;
   coronary artery disease
ID GLYCATION-END-PRODUCTS; BODY-MASS INDEX; ENDOGENOUS SECRETORY RAGE;
   LOW-DENSITY-LIPOPROTEIN; LOW-CALORIE DIET; NF-KAPPA-B; ADVANCED
   GLYCOSYLATION; SOLUBLE RECEPTOR; HEART-DISEASE; NITRIC-OXIDE
AB This article deals with the role of AGE (advanced glycation end products)-RAGE (receptor for AGE) stress (AGE/sRAGE) in the development of coronary artery disease (CAD) in obesity. CAD is due to atherosclerosis in coronary artery. The serum/plasma levels of AGE and sRAGE are reduced, while AGE-RAGE stress and expression of RAGE are elevated in obese individuals. However, the levels of AGE are elevated in obese individuals with more than one metabolic syndrome. The increases in the AGE-RAGE stress would elevate the expression and production of atherogenic factors, including reactive oxygen species, nuclear factor-kappa B, cytokines, intercellular adhesion molecule-1, vascular cell adhesion molecule-1, endothelial leukocyte adhesion molecules, monocyte chemoattractant protein-1, granulocyte-macrophage colony-stimulating factor, and growth factors. Low levels of sRAGE would also increase the atherogenic factors. The increases in the AGE-RAGE stress and decreases in the levels of sRAGE would induce development of atherosclerosis, leading to CAD. The therapeutic regimen for AGE-RAGE stress-induced CAD in obesity would include lowering of AGE intake, prevention of AGE formation, degradation of AGE in vivo, suppression of RAGE expression, blockade of AGE-RAGE interaction, downregulation of sRAGE expression, and use of antioxidants. In conclusion, the data suggest that AGE-RAGE stress is involved in the development of CAD in obesity, and the therapeutic interventions to reduce AGE-RAGE would be helpful in preventing, regressing, and slowing the progression of CAD in obesity.
C1 [Prasad, Kailash] Univ Saskatchewan, Coll Med, Dept Physiol APP, 107 Wiggins Rd, Saskatoon, SK S7N 5E5, Canada.
   [Khan, Amal S.] Univ Saskatchewan, Coll Med, Community Hlth & Epidemiol, Saskatoon, SK, Canada.
   [Bhanumathy, Kalpana K.] Univ Saskatchewan, Coll Med, Div Oncol, Canc Cluster Unit, Saskatoon, SK, Canada.
C3 University of Saskatchewan; University of Saskatchewan; University of
   Saskatchewan
RP Prasad, K (corresponding author), Univ Saskatchewan, Coll Med, Dept Physiol APP, 107 Wiggins Rd, Saskatoon, SK S7N 5E5, Canada.
EM k.prasad@usask.ca
OI /0000-0001-8615-4024
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NR 110
TC 3
Z9 3
U1 0
U2 8
PU THIEME MEDICAL PUBL INC
PI NEW YORK
PA 333 SEVENTH AVE, NEW YORK, NY 10001 USA
SN 1061-1711
EI 1615-5939
J9 INT J ANGIOL
JI Int. J. Angiol.
PD MAR
PY 2022
VL 31
IS 01
BP 1
EP 9
DI 10.1055/s-0042-1742587
EA FEB 2022
PG 9
WC Peripheral Vascular Disease
WE Emerging Sources Citation Index (ESCI)
SC Cardiovascular System & Cardiology
GA ZI0CC
UT WOS:000754323800004
PM 35221846
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Golbidi, S
   Li, HG
   Laher, I
AF Golbidi, Saeid
   Li, Huige
   Laher, Ismail
TI Oxidative Stress: A Unifying Mechanism for Cell Damage Induced by Noise,
   (Water-Pipe) Smoking, and Emotional Stress-Therapeutic Strategies
   Targeting Redox Imbalance
SO ANTIOXIDANTS & REDOX SIGNALING
LA English
DT Review
DE smoking; noise; mental stress; oxidative stress; antioxidants; exercise
ID INDUCED HEARING-LOSS; OBSTRUCTIVE PULMONARY-DISEASE; HEAT-SHOCK-PROTEIN;
   BLOOD MONONUCLEAR-CELLS; NITRIC-OXIDE SYNTHASE; CIGARETTE-SMOKING;
   LIPID-PEROXIDATION; PHYSICAL-ACTIVITY; N-ACETYLCYSTEINE; GENE-EXPRESSION
AB Significance: Modern technologies have eased our lives but these conveniences can impact our lifestyles in destructive ways. Noise pollution, mental stresses, and smoking (as a stress-relieving solution) are some environmental hazards that affect our well-being and healthcare budgets. Scrutinizing their pathophysiology could lead to solutions to reduce their harmful effects.
   Recent Advances: Oxidative stress plays an important role in initiating local and systemic inflammation after noise pollution, mental stress, and smoking. Lipid peroxidation and release of lysolipid by-products, disturbance in activation and function of nuclear factor erythroid 2-related factor 2 (Nrf2), induction of stress hormones and their secondary effects on intracellular kinases, and dysregulation of intracellular Ca2+ can all potentially trigger other vicious cycles. Recent clinical data suggest that boosting the antioxidant system through nonpharmacological measures, for example, lifestyle changes that include exercise have benefits that cannot easily be achieved with pharmacological interventions alone.
   Critical Issues: Indiscriminate manipulation of the cellular redox network could lead to a new series of ailments. An ideal approach requires meticulous scrutiny of redox balance mechanisms for individual pathologies so as to create new treatment strategies that target key pathways while minimizing side effects.
   Future Directions: Extrapolating our understanding of redox balance to other debilitating conditions such as diabetes and the metabolic syndrome could potentially lead to devising a unifying therapeutic strategy. Antioxid. Redox Signal. 00, 000-000.
C1 [Golbidi, Saeid; Laher, Ismail] Univ British Columbia, Fac Med, Dept Pharmacol & Therapeut, Vancouver, BC V6T 1Z3, Canada.
   [Li, Huige] Johannes Gutenberg Univ Med Ctr, Dept Pharmacol, Mainz, Germany.
C3 University of British Columbia; Johannes Gutenberg University of Mainz
RP Laher, I (corresponding author), Univ British Columbia, Fac Med, Dept Pharmacol & Therapeut, Vancouver, BC V6T 1Z3, Canada.
EM ilaher@mail.ubc.ca
RI Laher, Ismail/X-3323-2019; Li, Huige/M-2662-2013
OI Li, Huige/0000-0003-3458-7391
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NR 214
TC 40
Z9 42
U1 1
U2 9
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1523-0864
EI 1557-7716
J9 ANTIOXID REDOX SIGN
JI Antioxid. Redox Signal.
PD MAR
PY 2018
VL 28
IS 9
BP 741
EP 759
DI 10.1089/ars.2017.7257
EA JAN 2018
PG 19
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA FY1GC
UT WOS:000419900500001
PM 29212347
DA 2025-06-11
ER

PT J
AU Agouni, A
   Mody, N
   Owen, C
   Czopek, A
   Zimmer, D
   Bentires-Alj, M
   Bence, KK
   Delibegovic, M
AF Agouni, Abdelali
   Mody, Nimesh
   Owen, Carl
   Czopek, Alicja
   Zimmer, Derek
   Bentires-Alj, Mohamed
   Bence, Kendra K.
   Delibegovic, Mirela
TI Liver-specific deletion of protein tyrosine phosphatase (PTP) 1B
   improves obesity- and pharmacologically induced endoplasmic reticulum
   stress
SO BIOCHEMICAL JOURNAL
LA English
DT Article
DE endoplasmic reticulum (ER) stress; insulin resistance; metabolic
   syndrome; obesity; protein tyrosine phosphatase 1B (PTP1B)
ID ER STRESS; BINDING PROTEIN-1; GENE-EXPRESSION; GLUCOSE-HOMEOSTASIS;
   INSULIN SENSITIVITY; SIGNAL-TRANSDUCTION; HEPATIC STEATOSIS; OXIDATIVE
   STRESS; LEPTIN ACTION; IN-VIVO
AB Obesity is associated with induction of the ER (endoplasmic reticulum)-stress response signalling and insulin resistance. PTP1B (protein tyrosine phosphatase 1B) is a major regulator of adiposity and insulin sensitivity. The aim of the present study was to investigate the role of L-PTP1B (liver-specific PTP1B) in chronically HFD (high-fat diet) and pharmacologically induced (tunicamycin and thapsigargin) ER-stress response signalling in vitro and in vivo. We assessed the effects of ER-stress response induction on hepatic PTP1B expression, and consequences of hepatic-PTP1B deficiency, in cells and mouse liver, on components of ER-stress response signalling. We found that PTP1B protein and mRNA expression levels were up-regulated in response to acute and/or chronic ER stress, in vitro and in vivo. Silencing PTP1B in hepatic cell lines or mouse liver (L-PTP1B(-/-)) protected against induction of pharmacologically induced and/or obesity-induced ER stress. The HFD-induced increase in CHOP (CCAAT/enhancer-binding protein homologous protein) and BIP (binding immunoglobulin protein) mRNA levels were partially inhibited, whereas ATF4 (activated transcription factor 4), GADD34 (growth-arrest and DNA-damage-inducible protein 34), GRP94 (glucose-regulated protein 94), ERDJ4 (ER-localized DnaJ homologue) mRNAs and ATF6 protein cleavage were completely suppressed in L-PTP1B(-/-) mice relative to control littermates. L-PTP1B(-/-) mice also had increased nuclear translocation of spliced XBP-1 (X box-binding protein-1) via increased p85 alpha binding. We demonstrate that the ER-stress response and L-PTP1B expression are interlinked in obesity- and pharmacologically induced ER stress and this may be one of the mechanisms behind improved insulin sensitivity and lower lipid accumulation in L-PTP1B(-/-) mice.
C1 [Agouni, Abdelali; Mody, Nimesh; Owen, Carl; Czopek, Alicja; Delibegovic, Mirela] Univ Aberdeen, Coll Life Sci & Med, Inst Biol & Environm Sci, Aberdeen AB25 2ZD, Scotland.
   [Zimmer, Derek; Bence, Kendra K.] Univ Penn, Sch Vet Med, Dept Anim Biol, Philadelphia, PA 19104 USA.
   [Bentires-Alj, Mohamed] Friedrich Miescher Inst Biomed Res, Basel, Switzerland.
C3 University of Aberdeen; University of Pennsylvania; Friedrich Miescher
   Institute for Biomedical Research
RP Delibegovic, M (corresponding author), Univ Aberdeen, Coll Life Sci & Med, Inst Biol & Environm Sci, Aberdeen AB25 2ZD, Scotland.
EM m.delibegovic@abdn.ac.uk
RI Mody, Nimesh/J-9602-2019; Agouni, Abdelali/AAP-5298-2020; Bentires-Alj,
   Mohamed/F-4484-2015
OI Bence, Kendra/0000-0002-5879-4726; Bentires-Alj,
   Mohamed/0000-0001-6344-1127; Agouni, Abdelali/0000-0002-8363-1582;
   Delibegovic, Mirela/0000-0001-6193-3152; Mody,
   Nimesh/0000-0002-2215-7952
FU Diabetes UK [BDARD08/0003597]; RCUK (Research Councils U.K.); British
   Heart Foundation; Royal Society; BBSRC (Biotechnology and Biological
   Sciences Research Council); USDA (United States Department of
   Agriculture); National Institutes of Health [RO1DK082417]; Tenovus
   Scotland
FX This work was supported by Diabetes UK (project grant number
   BDARD08/0003597 (to M.D.)], and also by RCUK (Research Councils U.K.)
   Fellowship, British Heart Foundation, Tenovus Scotland and the Royal
   Society (to M.D.). N.M. is funded by a career development fellowship
   from the British Heart Foundation. C.O. is funded by the BBSRC
   (Biotechnology and Biological Sciences Research Council) postdoctoral
   training studentship. K.K.B. is funded by the USDA (United States
   Department of Agriculture) and National Institutes of Health [grant
   number RO1DK082417].
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NR 48
TC 90
Z9 101
U1 1
U2 23
PU PORTLAND PRESS LTD
PI LONDON
PA THIRD FLOOR, EAGLE HOUSE, 16 PROCTER STREET, LONDON WC1V 6 NX, ENGLAND
SN 0264-6021
J9 BIOCHEM J
JI Biochem. J.
PD SEP 1
PY 2011
VL 438
BP 369
EP 378
DI 10.1042/BJ20110373
PN 2
PG 10
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 824IK
UT WOS:000295195400014
PM 21605081
OA Green Submitted, Green Accepted, Green Published
DA 2025-06-11
ER

PT J
AU Xu, YJ
   Tappia, PS
   Neki, NS
   Dhalla, NS
AF Xu, Yan-Jun
   Tappia, Paramjit S.
   Neki, Nirankar S.
   Dhalla, Naranjan S.
TI Prevention of diabetes-induced cardiovascular complications upon
   treatment with antioxidants
SO HEART FAILURE REVIEWS
LA English
DT Article
DE Oxidative stress; Atherosclerosis; Resveratrol; Cardiovascular disease;
   Diabetes; Antioxidants
ID CONGESTIVE-HEART-FAILURE; CELL-ADHESION MOLECULE-1;
   LOW-DENSITY-LIPOPROTEIN; OXIDATIVE STRESS; N-ACETYLCYSTEINE; RESVERATROL
   IMPROVES; REDOX REGULATION; CLINICAL-TRIAL; BLOOD CARDIOPLEGIA;
   VITAMIN-E
AB Oxidative stress is considered to play an important role in the pathogenesis of diabetes-induced cardiovascular disease (CVD), which is invariably associated with abnormal blood lipid profile, insulin resistance and metabolic syndrome. Stress, smoking, high saturated fat intake as well as low fruit and vegetable intakes have been shown to increase oxidative stress and hyperlipidemia, which increase the predisposition of diabetic subjects to atherosclerosis, stroke and coronary heart disease. The oxidation of low-density lipoprotein by oxidative stress is essential for the development of atherosclerosis, and the reduction in oxidative stress as well as blood glucose and cholesterol is considered critical for the prevention of diabetes-induced CVD. Although epidemiological studies have demonstrated that vitamin C and vitamin E decrease the incidence of coronary heart disease, different clinical trials have failed to support the beneficial effect of these antioxidants. Nonetheless, it has been suggested that natural forms of these vitamins may be more efficacious than synthetic vitamins, and this may explain the inconsistencies in results. Antioxidants, N-acetyl-l-cysteine and resveratrol, have also been shown to attenuate the diabetes-induced cardiovascular complications. It has been indicated that the antioxidant therapy may be effective in a prevention strategy rather than as a treatment for CVD. The evidence presented here supports the view that cardiovascular complications in diabetes may be induced by oxidative stress and appropriate antioxidant therapy may be promising for attenuating the progression of diabetes-induced CVD.
C1 [Xu, Yan-Jun; Neki, Nirankar S.; Dhalla, Naranjan S.] Univ Manitoba, St Boniface Hosp Res, Inst Cardiovasc Sci, Dept Physiol,Fac Med, Winnipeg, MB R2H 2A6, Canada.
   [Tappia, Paramjit S.] St Boniface Hosp Res, Asper Clin Res Inst, Winnipeg, MB, Canada.
C3 University of Manitoba; Saint Boniface Hospital; University of Manitoba;
   Saint Boniface Hospital
RP Dhalla, NS (corresponding author), Univ Manitoba, St Boniface Hosp Res, Inst Cardiovasc Sci, Dept Physiol,Fac Med, 351 Tache Ave, Winnipeg, MB R2H 2A6, Canada.
EM nsdhalla@sbrc.ca
RI Dhalla, Naranjan/C-8279-2014
OI N.S. Neki, Dr./0000-0002-8255-0019
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NR 80
TC 69
Z9 71
U1 0
U2 28
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1382-4147
EI 1573-7322
J9 HEART FAIL REV
JI Heart Fail. Rev.
PD JAN
PY 2014
VL 19
IS 1
SI SI
BP 113
EP 121
DI 10.1007/s10741-013-9379-6
PG 9
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 284NH
UT WOS:000329325400010
PM 23436032
DA 2025-06-11
ER

PT J
AU Omidkhoda, SF
   Hosseinzadeh, H
AF Omidkhoda, Seyedeh Farzaneh
   Hosseinzadeh, Hossein
TI Saffron and its active ingredients against human disorders: A literature
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SO IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
LA English
DT Review
DE Clinical trial; Crocin; Disease; Disorder; Saffron; Therapy
ID CROCUS-SATIVUS-L.; TO-MODERATE DEPRESSION; TYPE-2 DIABETES-MELLITUS;
   DOUBLE-BLIND; METABOLIC SYNDROME; AQUEOUS EXTRACT; ERECTILE DYSFUNCTION;
   ALCOHOLIC EXTRACT; RAT MODEL; PREMENSTRUAL-SYNDROME
AB Saffron, the stigmas of Crocus sativus L., has been mentioned extensively in the traditional reference texts as a herbal medicine. Many clinical trials have been conducted on this valuable herbal substance and its main constituents following numerous cellular and animal assessments. In the present review, we have collected almost all of these clinical studies to clarify how much knowledge has clinically been achieved in this field so far and which scientific gaps are needed to be filled by more studies. A comprehensive literature review was conducted through a two-round search. First, we performed a general search for identifying the human disorders against which saffron was studied. Then, we searched specifically for the combination of saffron keywords and each disease name. Scientific databases including Scopus, PubMed, and Web of science were used for this search. Studies were collected through electronic databases from their inception up to August 2021. The largest number of these clinical studies represent the investigations into saffron efficacy in different neurological and mental disorders, particularly depression. This substance has clinically revealed significant protective effects against various types of depression, age-related macular degeneration, and allergic asthma. In some cases, such as sexual dysfunction, cognitive and metabolic disorder, the effects of saffron are still clinically open to dispute, or there are limited data on its positive influences. Overall, saffron and its constituents have promising effects on human disorders; however, it needs more clinical evidence or meta-analyses to be confirmed.
C1 [Omidkhoda, Seyedeh Farzaneh; Hosseinzadeh, Hossein] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Pharmaceut Res Ctr, Mashhad, Razavi Khorasan, Iran.
   [Hosseinzadeh, Hossein] Mashhad Univ Med Sci, Sch Pharm, Dept Pharmacodynam & Toxicol, Mashhad, Razavi Khorasan, Iran.
C3 Mashhad University of Medical Sciences; Mashhad University of Medical
   Sciences
RP Hosseinzadeh, H (corresponding author), Mashhad Univ Med Sci, Pharmaceut Technol Inst, Pharmaceut Res Ctr, Mashhad, Razavi Khorasan, Iran.; Hosseinzadeh, H (corresponding author), Mashhad Univ Med Sci, Sch Pharm, Dept Pharmacodynam & Toxicol, Mashhad, Razavi Khorasan, Iran.
EM hosseinzadehh@mums.ac.ir
RI Hosseinzadeh, Hossein/F-3013-2010
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NR 152
TC 20
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U1 0
U2 13
PU MASHHAD UNIV MED SCIENCES
PI MASHHAD
PA VICE-CHANCELLOR FOR RES CTR OFF IJBMS, DANESHGAH ST, PO BOX 9138813944 -
   445, MASHHAD, 00000, IRAN
SN 2008-3866
EI 2008-3874
J9 IRAN J BASIC MED SCI
JI Iran. J. Basic Med. Sci.
PD AUG
PY 2022
VL 25
IS 8
BP 913
EP 933
DI 10.22038/IJBMS.2022.63378.13985
PG 21
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA 3Z1HD
UT WOS:000844170200001
PM 36159329
DA 2025-06-11
ER

PT J
AU Andersen, E
   Bang-Kittilsen, G
   Bigseth, TT
   Egeland, J
   Holmen, TL
   Martinsen, EW
   Stensrud, T
   Engh, JA
AF Andersen, Eivind
   Bang-Kittilsen, Gry
   Bigseth, Therese Torgersen
   Egeland, Jens
   Holmen, Tom Langerud
   Martinsen, Egil Wilhelm
   Stensrud, Trine
   Engh, John Abel
TI Effect of high-intensity interval training on cardiorespiratory fitness,
   physical activity and body composition in people with schizophrenia: a
   randomized controlled trial
SO BMC PSYCHIATRY
LA English
DT Article
DE Schizophrenia; RCT; Exercise; Maximal oxygen uptake; Physical activity
ID MAJOR DEPRESSIVE DISORDER; BIPOLAR DISORDER; MENTAL-ILLNESS;
   CARDIOVASCULAR-DISEASE; SEDENTARY BEHAVIOR; METABOLIC SYNDROME; EXERCISE
   CAPACITY; DIABETES-MELLITUS; OXYGEN-UPTAKE; MORTALITY
AB Background: Exercise may improve cardiorespiratory fitness in people with schizophrenia, however, possible condition-specific cardiorespiratory disadvantages, a scarcity of methodologically sound studies, and conflicting results raise questions about the effect of exercise on maximal oxygen uptake (VO2max) in this group. The primary aim of this study, therefore, was to investigate the effect of high-intensity interval training on VO2max in people with schizophrenia. Second, we sought to determine whether the intervention would have an effect on general physical activity (PA) level and body composition.
   Methods: Eighty-two patients with schizophrenia were randomly assigned to supervised high-intensity interval training or computer gaming skills training, performed twice a week for 12 weeks. Oxygen uptake was measured directly, during a maximum exercise session on a treadmill. PA level were assessed using ActiGraph accelerometer, and body composition was assessed by bioelectrical impedance. Differences between groups were assessed by analysis of variance using a univariate general linear model.
   Results: There were no significant differences between the groups on any of the cardiorespiratory variables neither at baseline nor after the program. There were also no significant within-group differences in any of the cardiorespiratory fitness variables between the baseline and post-program time points, despite that 61% of the participants performing high-intensity interval training showed a significant increase in workload on the treadmill. However, 47% of the participants in the high-intensity interval training group had a >= 5% increase in VO2max. Participants supervised by mental health care providers with PA competence (e.g. rehabilitation center staff, sport scientist, physical trainer) had a much larger increase in VO2max compared to participants supervised by mental health workers without such competence, and when adding PA competence to the model, the intervention group increased VO2max significantly compared to the comparison group. The intervention had no significant effect on PA level or body composition.
   Conclusions: The intervention did not improve VO2max, PA level or body composition but succeeded in increasing workload on the treadmill. With regard to VO2max, approximately half of the patients may be considered responders.
C1 [Andersen, Eivind] Univ South Eastern Norway, Fac Humanities Sports & Educ Sci, POB 235, N-3603 Kongsberg, Horten, Norway.
   [Bang-Kittilsen, Gry; Bigseth, Therese Torgersen; Egeland, Jens; Holmen, Tom Langerud; Engh, John Abel] Vestfold Hosp Trust, Div Mental Hlth & Addict, Tonsberg, Norway.
   [Egeland, Jens] Univ Oslo, Dept Psychol, Oslo, Norway.
   [Martinsen, Egil Wilhelm] Oslo Univ Hosp, Clin Mental Hlth & Addict, Oslo, Norway.
   [Martinsen, Egil Wilhelm] Univ Oslo, Inst Clin Med, Oslo, Norway.
   [Stensrud, Trine] Norwegian Sch Sports Sci, Dept Sports Med, Oslo, Norway.
C3 University of South-Eastern Norway; University of Oslo; University of
   Oslo; University of Oslo; Norwegian School of Sport Sciences
RP Andersen, E (corresponding author), Univ South Eastern Norway, Fac Humanities Sports & Educ Sci, POB 235, N-3603 Kongsberg, Horten, Norway.
EM eivind.andersen@usn.no
RI Engh, John/AAG-6446-2021
FU Vestfold Hospital Trust; South-Eastern Norway Regional Health Authority;
   Norwegian Extra Foundation for Health and Rehabilitation through EXTRA
   funds; Norwegian Research network in Severe Mental Illness (NORSMI);
   NORMENT/KG Jebsen Center for Psychosis Research; Torgeir Lindvik's
   Trust; Civitan International
FX The main study (EPHAPS) has received funding from Vestfold Hospital
   Trust, South-Eastern Norway Regional Health Authority, Norwegian Extra
   Foundation for Health and Rehabilitation through EXTRA funds, Norwegian
   Research network in Severe Mental Illness (NORSMI), NORMENT/KG Jebsen
   Center for Psychosis Research, Torgeir Lindvik's Trust, and Civitan
   International. The funders had no role in study design, data collection
   and analysis, decision to publish, or preparation of the manuscript.
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NR 69
TC 20
Z9 21
U1 1
U2 19
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-244X
J9 BMC PSYCHIATRY
JI BMC Psychiatry
PD AUG 27
PY 2020
VL 20
IS 1
AR 425
DI 10.1186/s12888-020-02827-2
PG 12
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA NK7RN
UT WOS:000566930200002
PM 32854688
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Masumi, H
   Karimi, M
   Sharifi, MH
   Ghaem, H
AF Masumi, Hamideh
   Karimi, Masoud
   Sharifi, Mohammad Hossein
   Ghaem, Hale
TI The impact of small group education methods on adherence to the
   Mediterranean diet and quality of life in Iranian elderly women
SO INTERNATIONAL JOURNAL OF HEALTH PROMOTION AND EDUCATION
LA English
DT Article
DE Diet; Mediterranean; adherence; elderly; women; quality of life
ID NUTRITION EDUCATION; METABOLIC SYNDROME; INTERVENTION; RISK; POPULATION;
   HEALTH
AB Enhancing health and quality of life (QoL) of elderly people is technically challenging. The aim of this study was to examine the effectiveness of small group education method on adherence to Mediterranean diet and QoL in elderly women. In this randomized-controlled study, one hundred 60-74-year-old women were selected from two health centers using random sampling, in 2019, Shiraz, Iran. Each health center was randomly assigned to intervention and control groups (50 women in each group). The intervention group received four weekly education sessions using small group education method (group discussion, brainstorming and role-playing). We collected data through 14-item Mediterranean diet adherence, LEIPAD 31-item quality of life, and researcher-made knowledge and attitude questionnaires. The mean +/- standard deviation (SD) of the participants' age in the control and intervention groups were 62.7 +/- 3.9 and 63.1 +/- 3.7 years, respectively (p=0.71). Adherence to the Mediterranean diet increased significantly in the intervention group compared to the controls (p<0.001). The mean +/- SD of adherence to the Mediterranean diet changed from 7.24 (2.04) to 10.58 (1.33) in the intervention group (p<0.001). The total QOL score and two subscales, physical and depression/anxiety, increased significantly in the intervention group compared to the control group (p<0.015, p< 0.001 and p<0.018, respectively). Similarly, the mean scores of knowledge and attitude increased significantly in the intervention group compared to those of the control group (p<0.001 and p<0.001). It appears that small group education method can provide an effective strategy for increasing adherence to Mediterranean diet and QoL in the elderly.
C1 [Masumi, Hamideh; Karimi, Masoud] Shiraz Univ Med Sci, Sch Hlth, Dept Hlth Promot, 3rd Floor,Razi Ave POB 7153675541, Shiraz, Iran.
   [Sharifi, Mohammad Hossein] Shiraz Univ Med Sci, Res Ctr Tradit Med & Hist Med, Shiraz, Iran.
   [Ghaem, Hale] Shiraz Univ Med Sci, Sch Hlth, Dept Epidemiol, Shiraz, Iran.
C3 Shiraz University of Medical Science; Shiraz University of Medical
   Science; Shiraz University of Medical Science
RP Karimi, M (corresponding author), Shiraz Univ Med Sci, Sch Hlth, Dept Hlth Promot, 3rd Floor,Razi Ave POB 7153675541, Shiraz, Iran.
EM karimeim@sums.ac.ir
RI Sharifi, Mohammad Hossein/V-7430-2018; Karimi, Masoud/Q-5889-2017;
   ghaem, haleh/L-9985-2016
OI Sharifi, Mohammad Hossein/0000-0002-9927-5922; Karimi,
   Masoud/0000-0001-7931-4181; ghaem, haleh/0000-0001-9564-392X
FU Shiraz University of Medical Sciences; Shiraz University of Medical
   Sciences, Shiraz, Iran
FX This study was approved and supported by Shiraz University of Medical
   Sciences, Shiraz, Iran. Hereby, the authors would like to acknowledge
   the health care workers in the selected health clinics and the elderly
   women who participated in the study. They would also like to thank Ms.
   A. Keivanshekouh at the Research Improvement Center of Shiraz University
   of Medical Sciences for improving the use of English in the manuscript,
   and Dr. Mozhgan Seif, assistant professor of Biostatistics, Department
   of Epidemiology, School of Health, Shiraz University of Medical
   Sciences.
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NR 52
TC 2
Z9 2
U1 4
U2 7
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 1463-5240
EI 2164-9545
J9 INT J HEALTH PROMOT
JI Int. J. Health Promot. Educ.
PD NOV 1
PY 2024
VL 62
IS 6
BP 591
EP 607
DI 10.1080/14635240.2022.2081867
EA JUN 2022
PG 17
WC Education, Scientific Disciplines
WE Emerging Sources Citation Index (ESCI)
SC Education & Educational Research
GA O9Q0T
UT WOS:000804028800001
DA 2025-06-11
ER

PT J
AU Sajatovic, M
   Gunzler, DD
   Kanuch, SW
   Cassidy, KA
   Tatsuoka, C
   McCormick, R
   Blixen, CE
   Perzynski, AT
   Einstadter, D
   Thomas, CL
   Lawless, ME
   Martin, S
   Falck-Ytter, C
   Seeholzer, EL
   McKibben, CL
   Bauer, MS
   Dawson, NV
AF Sajatovic, Martha
   Gunzler, Douglas D.
   Kanuch, Stephanie W.
   Cassidy, Kristin A.
   Tatsuoka, Curtis
   McCormick, Richard
   Blixen, Carol E.
   Perzynski, Adam T.
   Einstadter, Douglas
   Thomas, Charles L.
   Lawless, Mary E.
   Martin, Siobhan
   Falck-Ytter, Corinna
   Seeholzer, Eileen L.
   McKibben, Christine L.
   Bauer, Mark S.
   Dawson, Neal V.
TI A 60-Week Prospective RCT of a Self-Management Intervention for
   Individuals With Serious Mental Illness and Diabetes Mellitus
SO PSYCHIATRIC SERVICES
LA English
DT Article
ID HEALTH-CARE; ATYPICAL ANTIPSYCHOTICS; MEDICAL COMORBIDITY; METABOLIC
   SYNDROME; SUBSTANCE USE; OLDER-ADULTS; RISK-FACTORS; SCHIZOPHRENIA;
   MORTALITY; SCALE
AB Objectives: A 60-week randomized controlled trial assessed the effects of targeted training in illness management (TTIM) versus treatment as usual among 200 individuals with serious mental illness and diabetes mellitus.
   Methods: The study used the Clinical Global Impression (CGI), the Montgomery-Asberg Depression Rating Scale (MADRS), and the Brief Psychiatric Rating Scale (BPRS) to assess psychiatric symptoms; the Global Assessment of Functioning (GAF) and the Sheehan Disability Scale (SDS) to assess functioning; the 36-Item Short-Form Health Survey (SF-36) to assess general health, and serum glycosylated hemoglobin (HbA1c) to assess diabetes control.
   Results: Participants' mean +/- SD age was 52.7 +/- 9.5 years, and 54% were African American. They were diagnosed as having depression (48%), schizophrenia (25%), and bipolar disorder (28%). At baseline, depression severity was substantial but psychosis severity was modest. At 60 weeks, there was greater improvement among TTIM participants versus treatment-as-usual recipients on the CGI (p,. 001), the MADRS (p=.016), and the GAF (p=.003). Diabetes knowledge was significantly improved among TTIM participants but not in the treatment-as-usual group. In post hoc analyses among participants whose HbA1c levels at baseline met recommendations set by the American Diabetes Association for persons with high comorbidity (53%), TTIM participants had minimal change in HbA1c over the 60-week follow-up, whereas HbA1c levels worsened in the treatment-as-usual group.
   Conclusions: TTIM was associated with improved psychiatric symptoms, functioning, and diabetes knowledge compared with treatment as usual. Among participants with better diabetes control at baseline, TTIM participants had better diabetes control at 60 weeks compared with recipients of treatment as usual.
C1 [Sajatovic, Martha; Cassidy, Kristin A.; Blixen, Carol E.] Case Western Reserve Univ, Sch Med, Dept Psychiat, Cleveland, OH 44106 USA.
   [Tatsuoka, Curtis] Case Western Reserve Univ, Sch Med, Dept Neurol, Cleveland, OH 44106 USA.
   [Gunzler, Douglas D.; McCormick, Richard; Perzynski, Adam T.; Einstadter, Douglas; Thomas, Charles L.; Seeholzer, Eileen L.; Dawson, Neal V.] Case Western Reserve Univ, Sch Med, Ctr Hlth Care Res & Policy, Cleveland, OH 44106 USA.
   [Gunzler, Douglas D.; Kanuch, Stephanie W.; McCormick, Richard; Perzynski, Adam T.; Einstadter, Douglas; Thomas, Charles L.; Lawless, Mary E.; Martin, Siobhan; Dawson, Neal V.] Metrohlth Med Ctr, Cleveland, OH USA.
   [Falck-Ytter, Corinna] Louis Stokes Cleveland Vet Affairs VA Med Ctr, Cleveland, OH USA.
   [McKibben, Christine L.] Univ Wyoming, Dept Psychol, Laramie, WY 82071 USA.
   [Bauer, Mark S.] VA Boston Healthcare Syst, Ctr Healthcare Org & Implementat Res, Jamaica Plain, MA USA.
   [Bauer, Mark S.] Harvard Med Sch, Dept Psychiat, Boston, MA USA.
C3 University System of Ohio; Case Western Reserve University; University
   System of Ohio; Case Western Reserve University; University System of
   Ohio; Case Western Reserve University; MetroHealth System; University
   System of Ohio; Case Western Reserve University; US Department of
   Veterans Affairs; Veterans Health Administration (VHA); Louis Stokes
   Cleveland Veterans Affairs Medical Center; University of Wyoming;
   Harvard University; Harvard University Medical Affiliates; US Department
   of Veterans Affairs; Veterans Health Administration (VHA); VA Boston
   Healthcare System; Harvard University; Harvard Medical School
RP Sajatovic, M (corresponding author), Case Western Reserve Univ, Sch Med, Dept Psychiat, Cleveland, OH 44106 USA.
EM martha.sajatovic@UHhospitals.org
RI Tatsuoka, Curtis/HLX-2752-2023; Perzynski, Adam/AAX-5730-2020;
   Sajatovic, Martha/I-8001-2014
OI Perzynski, Adam/0000-0002-1323-0353
FU NIMH of the National Institutes of Health (NIH) [R01MH085665]; National
   Center for Research Resources (NCRR), a component of the NIH [UL1
   RR024989]; NIH/NCRR Clinical and Translational Science Award
   [KL2TR000440]; Alkermes; Janssen; Merck; Reinberger Foundation; Reuter
   Foundation; Woodruff Foundation
FX Research reported in this article was supported by the NIMH of the
   National Institutes of Health (NIH) under award number R01MH085665. The
   project was also supported by grant UL1 RR024989 from the National
   Center for Research Resources (NCRR), a component of the NIH, and by
   NIH/NCRR Clinical and Translational Science Award KL2TR000440. The
   clinical trial is registered at ClinicalTrials.gov. The contents of this
   article are solely the responsibility of the authors and do not
   necessarily represent the official views of the NCRR or the NIH.Dr.
   Sajatovic has received research support from Alkermes, Janssen, Merck,
   the Reinberger Foundation, the Reuter Foundation, and the Woodruff
   Foundation; serves as a consultant for Bracket, Health Analytics,
   Neurocrine, Otsuka, Prophase, Pfizer, Sunovion, and Supernus; receives
   royalties from Springer, Johns Hopkins University Press, Oxford Press,
   UpToDate, and Lexicomp; and participates in CME activities for the
   American Physician's Institute, MCM Education, and CMEology. Dr.
   Perzynski is cofounder of Global Health Metrics, L.L.C., a company in
   Cleveland that produces health risk assessment software. He has a
   current book contract with Springer. The other authors report no
   financial relationships with commercial interests.
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NR 51
TC 36
Z9 40
U1 0
U2 11
PU AMER PSYCHIATRIC PUBLISHING, INC
PI ARLINGTON
PA 1000 WILSON BOULEVARD, STE 1825, ARLINGTON, VA 22209-3901 USA
SN 1075-2730
EI 1557-9700
J9 PSYCHIAT SERV
JI Psychiatr. Serv.
PD SEP 1
PY 2017
VL 68
IS 9
BP 883
EP 890
DI 10.1176/appi.ps.201600377
PG 8
WC Health Policy & Services; Public, Environmental & Occupational Health;
   Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services; Public, Environmental & Occupational
   Health; Psychiatry
GA FI9YL
UT WOS:000412365600006
PM 28502243
OA Bronze, Green Accepted
DA 2025-06-11
ER

PT J
AU Park, JH
   Jung, SJ
   Jung, YJ
   Ahn, SV
   Lee, E
   Kim, HC
AF Park, Ji Hye
   Jung, Sun Jae
   Jung, YunJae
   Ahn, Song Vogue
   Lee, Eun
   Kim, Hyeon Chang
TI Association between the change of total cholesterol during adolescence
   and depressive symptoms in early adulthood
SO EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
LA English
DT Article
DE Serum total cholesterol; Depressive symptoms; Adolescence; Early
   adulthood
ID KOREA NATIONAL-HEALTH; LOW SERUM-CHOLESTEROL; MAJOR DEPRESSION;
   GENDER-DIFFERENCES; METABOLIC SYNDROME; LIPIDS; DISORDER; SUICIDE;
   PROFILE; RISK
AB Increasing evidence suggests that serum lipids are associated with depressive symptoms. However, previous studies have mostly employed a cross-sectional design and assessed middle-aged or older adult populations, making it difficult to discern the impact of lipid changes early in life on the development of depression. Accordingly, we sought to investigate changes in blood cholesterol levels during adolescence and the development of depressive symptoms in early adulthood. This prospective cohort study included participants aged 15-16 years from the JS High School Study (JSHS), with an average follow-up of 6 years. Participants had no diagnosed depression at baseline. Multivariable linear regression models were used to estimate associations between changes in total cholesterol during adolescence and depressive symptoms in adulthood. Changes in total cholesterol during adolescence were classified as "consistently low," "decreased," "moderate," "increased," or "consistently high". In men, depressive symptoms were higher in the consistently low (beta = 3.20, p = 0.036) and increased total cholesterol groups (beta = 3.48, p = 0.017), compared with the moderate group. In the consistently high group, although a positive linear association was observed, it lacked statistical significance (beta = 2.71, p = 0.067). While similar tendencies were noted in women, the associations were not statistically significant. Consistently low or increased total cholesterol levels during adolescence may pose an increased risk of depressive symptoms in early adulthood. These findings suggest that different strategies should be adopted to manage the lipid risk factors with consideration of age and sex.
C1 [Park, Ji Hye; Jung, Sun Jae; Kim, Hyeon Chang] Yonsei Univ, Coll Med, Dept Prevent Med, 50-1 Yonsei Ro, Seoul 120752, South Korea.
   [Park, Ji Hye; Kim, Hyeon Chang] Yonsei Univ, Coll Med, Cardiovasc & Metab Dis Etiol Res Ctr, Seoul, South Korea.
   [Jung, Sun Jae] Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA.
   [Jung, YunJae] Gachon Univ, Coll Med, Dept Microbiol, Incheon, South Korea.
   [Jung, YunJae] Gachon Univ, Gachon Adv Inst Hlth Sci & Technol, Dept Hlth Sci & Technol, Incheon, South Korea.
   [Ahn, Song Vogue] Ewha Womans Univ, Dept Hlth Convergence, Ewhayeodae Gil 52, Seoul, South Korea.
   [Lee, Eun] Yonsei Univ, Coll Med, Dept Psychiat, Seoul, South Korea.
   [Lee, Eun] Yonsei Univ, Coll Med, Inst Behav Sci Med, Seoul, South Korea.
C3 Yonsei University; Yonsei University Health System; Yonsei University;
   Yonsei University Health System; Harvard University; Harvard T.H. Chan
   School of Public Health; Gachon University; Gachon University; Ewha
   Womans University; Yonsei University; Yonsei University Health System;
   Yonsei University; Yonsei University Health System
RP Kim, HC (corresponding author), Yonsei Univ, Coll Med, Dept Prevent Med, 50-1 Yonsei Ro, Seoul 120752, South Korea.; Kim, HC (corresponding author), Yonsei Univ, Coll Med, Cardiovasc & Metab Dis Etiol Res Ctr, Seoul, South Korea.
EM hckim@yuhs.ac
RI Jung, Sun/ABC-7826-2020; Ahn, Song/AAK-2900-2021; Kim,
   Woo/AAG-1822-2019; Kim, Hyeon Chang/F-8796-2019; Jung, Sun
   Jae/D-5620-2011
OI JUNG, YUNJAE/0000-0002-1574-696X; Lee, Eun/0000-0002-7462-0144; Kim,
   Hyeon Chang/0000-0001-7867-1240; Jung, Sun Jae/0000-0002-5194-7339
FU Basic Science Research Program through a National Research Foundation of
   Korea (NRF) - Ministry of Education, Science and Technology (MEST)
   [2010-0007860, 2015R1D1A1A09057301]
FX This research was supported by Basic Science Research Program through a
   National Research Foundation of Korea (NRF) grant funded by the Ministry
   of Education, Science and Technology (MEST) (Nos. 2010-0007860,
   2015R1D1A1A09057301).
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NR 45
TC 10
Z9 12
U1 1
U2 8
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1018-8827
EI 1435-165X
J9 EUR CHILD ADOLES PSY
JI Eur. Child Adolesc. Psych.
PD FEB
PY 2021
VL 30
IS 2
BP 261
EP 269
DI 10.1007/s00787-020-01511-w
EA MAR 2020
PG 9
WC Psychology, Developmental; Pediatrics; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Pediatrics; Psychiatry
GA QR9HL
UT WOS:000520998400001
PM 32193646
DA 2025-06-11
ER

PT J
AU Jin, EH
   Han, K
   Lee, DH
   Shin, CM
   Lim, JH
   Yoon, H
   Kim, N
AF Jin, Eun Hyo
   Han, Kyungdo
   Lee, Dong Ho
   Shin, Cheol Min
   Lim, Joo Hyun
   Yoon, Hyuk
   Kim, Nayoung
TI Increased Risk of Major Depressive Disorder After Cholecystectomy: A
   Nationwide Population-Based Cohort Study in Korea
SO CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY
LA English
DT Article
ID GENERAL-POPULATION; METABOLIC SYNDROME; PREVALENCE; SYMPTOMS; DIARRHEA;
   ADULTS; HEALTH; LIFE
AB INTRODUCTION: This study investigated the risk of depression in Korean adults who underwent cholecystectomy and appeared for subsequent long-term follow-ups. A national population-based data set was used for analysis. METHODS: All patients (n = 111,934) aged 40 years and older who underwent cholecystectomy between 2010 and 2015 and a control population (n = 223,868), matched for age and sex, were identified from the database of the Korean National Health Insurance Corporation. The hazard ratio (HR) and 95% confidence interval (CI) of depression were estimated after cholecystectomy, and a Cox regression analysis was performed. RESULTS: The incidence of depression in the cholecystectomy group was 27.3 per 1,000 person-years and that in the control group was 20.3 per 1,000 person-years. Patients who underwent cholecystectomy showed an increased risk of major depressive disorder (MDD) with an adjusted HR (aHR) of 1.34 (95% CI: 1.31-1.37, P < 0.001). The mean follow-up period after a 1-year lag was 3.67 +/- 1.79 years. In the subgroup analysis, the risk of developing MDD after cholecystectomy was relatively high in patients aged 40-49 years (aHR 1.51, 95% CI: 1.44-1.58) and in participants without diabetes mellitus (aHR: 1.36, 95% CI: 1.33-1.39), hypertension (aHR: 1.38, 95% CI: 1.34-1.42), or dyslipidemia (aHR: 1.35, 95% CI: 1.32-1.38). DISCUSSION: Compared with the control population, patients who underwent cholecystectomy exhibited an increased incidence of MDD. Thus, physicians should implement an enhanced program of MDD screening for at least several years after cholecystectomy.
C1 [Jin, Eun Hyo; Lim, Joo Hyun] Seoul Natl Univ Hosp, Healthcare Res Inst, Dept Internal Med, Healthcare Syst Gangnam Ctr, Seoul, South Korea.
   [Han, Kyungdo] Soongsil Univ, Dept Stat & Actuarial Sci, Seoul, South Korea.
   [Lee, Dong Ho; Shin, Cheol Min; Yoon, Hyuk; Kim, Nayoung] Dept Internal Med, Seongnam, Gyeonggido, South Korea.
   [Lee, Dong Ho; Shin, Cheol Min; Yoon, Hyuk; Kim, Nayoung] Seoul Natl Univ, Bundang Hosp, Seongnam, Gyeonggido, South Korea.
C3 Seoul National University (SNU); Seoul National University Hospital;
   Soongsil University; Seoul National University (SNU)
RP Lee, DH (corresponding author), Dept Internal Med, Seongnam, Gyeonggido, South Korea.; Lee, DH (corresponding author), Seoul Natl Univ, Bundang Hosp, Seongnam, Gyeonggido, South Korea.
EM dhljohn@yahoo.co.kr
RI Kim, Nayoung/J-5387-2012; Yoon, Hyuk/AAT-4978-2020
OI Yoon, Hyuk/0000-0002-2657-0349; Shin, Cheol Min/0000-0003-2265-9845
CR Buono JL, 2017, HEALTH QUAL LIFE OUT, V15, DOI 10.1186/s12955-017-0611-2
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NR 32
TC 9
Z9 9
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
EI 2155-384X
J9 CLIN TRANSL GASTROEN
JI Clin. Transl. Gastroenterol.
PD APR
PY 2021
VL 12
IS 4
AR e00339
DI 10.14309/ctg.0000000000000339
PG 7
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Gastroenterology & Hepatology
GA TU9LI
UT WOS:000681350600004
PM 33929976
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Surtees, PG
   Wainwrigit, NWJ
   Boekholdt, SM
   Luben, RN
   Wareham, NJ
   Khaw, KT
AF Surtees, Paul G.
   Wainwrigit, Nicholas W. J.
   Boekholdt, S. Matthijs
   Luben, Robert N.
   Wareham, Nicholas J.
   Khaw, Kay-Tee
TI Major Depression, C-Reactive Protein, and Incident Ischemic Heart
   Disease in Healthy Men and Women
SO PSYCHOSOMATIC MEDICINE
LA English
DT Article
DE coronary disease; depressive disorder; epidemiology; inflammation
ID CORONARY-ARTERY-DISEASE; 3RD NATIONAL-HEALTH; METABOLIC SYNDROME;
   EPIC-NORFOLK; CARDIOVASCULAR-DISEASE; MYOCARDIAL-INFARCTION;
   INFLAMMATORY MARKERS; RISK; ASSOCIATION; POPULATION
AB Objective: To investigate how C-reactive protein (CRP) and major depressive disorder (MDD) relate to each other and to incident ischemic heart disease (IHD). Studies have shown that both depression and raised CRP concentration predict IHD and that elevated CRP is linked with increased risk of depression. Methods: A prospective case-control study of healthy men and women, aged 45 to 79 years, was undertaken within the United Kingdom European Prospective Investigation into Cancer (EPIC)-Norfolk study. CRP concentration was measured for 726 (fatal or nonfatal) IHD cases and 1688 matched controls who completed a baseline MDD self-assessment, defined by restricted Diagnostic and Statistical Manual of Mental Disorders, 4th Edition diagnostic criteria. Results: Past-year MDD was associated with increased CRP concentration levels (4.31 mg/L for participants who reported episodes of MDD in the past year versus 3.65 mg/L for those who did not; p =.003), and the odds ratio for incident IHD associated with higher CRP concentration was 2.02 (comparing the top versus bottom quartile of CRP; 95% Confidence Interval (CI) = 1.52-2.68), adjusted for cigarette smoking, diabetes, systolic blood pressure, body mass index, and cholesterol. The association between past-year MDD and IHD was independent of CRP (odds ratio = 1.55; 95% Cl = 1.01-2.37, with adjustments as above, and additionally for CRP). Conclusions: Evidence from this study is supportive of an association between MDD and CRP although it suggests that CRP does not account for the association between MDD and future IHD.
C1 [Surtees, Paul G.; Wainwrigit, Nicholas W. J.; Luben, Robert N.] Strangeways Res Lab, Cambridge CB1 8RN, England.
   [Surtees, Paul G.; Wainwrigit, Nicholas W. J.; Luben, Robert N.] Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England.
   [Boekholdt, S. Matthijs] Univ Amsterdam, Acad Med Ctr, Dept Cardiol, NL-1105 AZ Amsterdam, Netherlands.
   [Wareham, Nicholas J.] Inst Metab Sci, MRC Epidemiol Unit, Cambridge, England.
   [Khaw, Kay-Tee] Univ Cambridge, Addenbrookes Hosp, Sch Clin Med, Clin Gerontol Unit, Cambridge CB2 2QQ, England.
C3 University of Cambridge; University of Amsterdam; Academic Medical
   Center Amsterdam; University of Cambridge; Cambridge University
   Hospitals NHS Foundation Trust; Addenbrooke's Hospital; University of
   Cambridge
RP Surtees, PG (corresponding author), Strangeways Res Lab, Worts Causeway, Cambridge CB1 8RN, England.
EM paul.surtees@srl.cam.ac.uk
RI Luben, Robert/KIC-1257-2024; Boekholdt, Matthijs/G-7562-2014; Khaw,
   Kay-Tee/AAZ-3209-2021; Timpson, Nicholas/O-7548-2015
OI Luben, Robert/0000-0002-5088-6343; Boekholdt,
   Matthijs/0000-0002-0861-0765
FU Medical Research Council UK [G0300128, G0401527]; Cancer Research UK
   [C864/A8257]; Stroke Association [RG2759]; European Union; British Heart
   Foundation; Department of Health; Wellcome Trust; MRC [G0300128] Funding
   Source: UKRI
FX The EPIC-Norfolk psychosocial research program is supported by Grant
   G0300128 from the Medical Research Council UK (P.G.S.). EPIC-Norfolk is
   supported by program Grant G0401527 from the Medical Research Council UK
   (K.-T.K.), Grant C864/A8257 from the Cancer Research UK (K.-T.K.), Grant
   RG2759 from the Stroke Association (K.-T.K.), with additional support
   from the European Union, British Heart Foundation, Department of Health,
   and the Wellcome Trust.
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NR 50
TC 28
Z9 29
U1 0
U2 7
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0033-3174
EI 1534-7796
J9 PSYCHOSOM MED
JI Psychosom. Med.
PD OCT
PY 2008
VL 70
IS 8
BP 850
EP 855
DI 10.1097/PSY.0b013e318183acd5
PG 6
WC Psychiatry; Psychology; Psychology, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry; Psychology
GA 365JF
UT WOS:000260401100002
PM 18725428
DA 2025-06-11
ER

PT J
AU Selenius, JS
   Silveira, PP
   Salonen, M
   Kautiainen, H
   von Bonsdorff, M
   Kajantie, E
   Lahti, J
   Eriksson, JG
   Wasenius, NS
AF Selenius, Jannica S.
   Silveira, Patricia P.
   Salonen, Minna
   Kautiainen, Hannu
   von Bonsdorff, Mikaela
   Kajantie, Eero
   Lahti, Jari
   Eriksson, Johan G.
   Wasenius, Niko S.
TI The relationship between health-related quality of life and melancholic
   depressive symptoms is modified by brain insulin receptor gene network
SO SCIENTIFIC REPORTS
LA English
DT Article
ID METABOLIC SYNDROME; PSYCHOMETRIC PROPERTIES; INVENTORY-II; METAANALYSIS;
   ASSOCIATION; PREVALENCE; RESISTANCE; DISORDER
AB To investigate whether expression-based polygenic risk scores for the insulin receptor gene network (ePRS-IRs) modifiy the association between type of depressive symptoms and health-related quality of life (HRQoL). This cross-sectional study includes 1558 individuals from the Helsinki Birth Cohort Study. Between 2001 and 2004, the Short Form-36 questionnaire was employed to assess mental and physical components of HRQoL and Beck Depression Inventory (BDI) to assess depressive symptoms. Depressive symptoms were categorized into minimal (BDI < 10), non-melancholic and melancholic types of depression. The ePRS-IRs were calculated for the hippocampal (hePRS-IR) and the mesocorticolimbic (mePRS-IR) regions of the brain. General linear regression models adjusted for age, sex, population stratification, lifestyle factors and body mass index were applied to analyze the data. Both types of depressive symptoms were associated with lower HRQoL (p < 0.0001). HePRS-IR modified the association between the types of depression and mental HRQoL (p for interaction = 0.005). Melancholic type of depressive symptoms was associated with higher mental HRQoL compared to the non-melancholic symptoms among individuals with low hePRS-IR (adjusted mean 4.1, 95% CI 0.7-7.4, p = 0.018). However, no such difference was evident in moderate or high hePRS-IR groups as higher hePRS-IR was associated with lower mental HRQoL (B = - 3.4, 95% CI -5.6 to - 1.2) in individuals with melancholic type of depressive symptoms. No direct associations were detected between the ePRS-IRs and type of depressive symptoms or HRQoL. Variations in the glucose-insulin metabolism can lower HRQoL in individuals with melancholic depressive symptoms.
C1 [Selenius, Jannica S.; Salonen, Minna; von Bonsdorff, Mikaela; Eriksson, Johan G.; Wasenius, Niko S.] Folkhalsan Res Ctr, Finbyntie 136 Karjaa, Helsinki 10300, Finland.
   [Selenius, Jannica S.; Kautiainen, Hannu; Eriksson, Johan G.; Wasenius, Niko S.] Univ Helsinki, Dept Gen Practice & Primary Hlth Care, Helsinki, Finland.
   [Selenius, Jannica S.; Kautiainen, Hannu; Eriksson, Johan G.; Wasenius, Niko S.] Helsinki Univ Hosp, Helsinki, Finland.
   [Silveira, Patricia P.] McGill Univ, Fac Med, Dept Psychiat, 6875 Blvd LaSalle, Verdun, PQ H4H 1R3, Canada.
   [Silveira, Patricia P.] McGill Univ, Douglas Mental Hlth Univ Inst, Ludmer Ctr Neuroinformat & Mental Hlth, 6875 Blvd LaSalle, Verdun, PQ H4H 1R3, Canada.
   [Salonen, Minna] Natl Inst Hlth & Welf, Publ Hlth Promot Unit, Helsinki, Finland.
   [von Bonsdorff, Mikaela] Univ Jyvaskyla, Gerontol Res Ctr, Jyvaskyla, Finland.
   [von Bonsdorff, Mikaela] Univ Jyvaskyla, Fac Sport & Hlth Sci, Jyvaskyla, Finland.
   [Kajantie, Eero] Natl Inst Hlth & Welf, Publ Hlth Promot Unit, Oulu, Finland.
   [Kajantie, Eero] Oulu Univ Hosp, PEDEGO Res Unit, MRC Oulu, Oulu, Finland.
   [Kajantie, Eero] Univ Oulu, Oulu, Finland.
   [Kajantie, Eero] Helsinki Univ Hosp, Childrens Hosp, Helsinki, Finland.
   [Kajantie, Eero] Univ Helsinki, Helsinki, Finland.
   [Kajantie, Eero] Norwegian Univ Sci & Technol, Dept Clin & Mol Med, Trondheim, Norway.
   [Lahti, Jari] Univ Helsinki, Dept Psychol & Logoped, POB 63, Helsinki 00014, Finland.
   [Lahti, Jari] Univ Turku, Turku Inst Adv Studies, Turku 20014, Finland.
   [Eriksson, Johan G.] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Obstet & Gynecol, Singapore, Singapore.
   [Eriksson, Johan G.] Natl Univ Singapore, Yong Loo Lin Sch Med, Human Potential Translat Res Program, Singapore, Singapore.
   [Eriksson, Johan G.] ASTAR, Singapore Inst Clin Sci SICS, Singapore, Singapore.
C3 Folkhalsan Research Center; University of Helsinki; University of
   Helsinki; Helsinki University Central Hospital; McGill University;
   McGill University; Finland National Institute for Health & Welfare;
   University of Jyvaskyla; University of Jyvaskyla; Finland National
   Institute for Health & Welfare; University of Oulu; University of Oulu;
   University of Helsinki; Helsinki University Central Hospital; University
   of Helsinki; Norwegian University of Science & Technology (NTNU);
   University of Helsinki; University of Turku; National University of
   Singapore; National University of Singapore; Agency for Science
   Technology & Research (A*STAR); A*STAR - Singapore Institute for
   Clinical Sciences (SICS)
RP Selenius, JS (corresponding author), Folkhalsan Res Ctr, Finbyntie 136 Karjaa, Helsinki 10300, Finland.; Selenius, JS (corresponding author), Univ Helsinki, Dept Gen Practice & Primary Hlth Care, Helsinki, Finland.; Selenius, JS (corresponding author), Helsinki Univ Hosp, Helsinki, Finland.
EM jannica.selenius@helsinki.fi
RI Gibbs, J. Raphael/A-3984-2010; Silveira, Patricia/A-7139-2011; Wasenius,
   Niko/AAE-8927-2020; Silveira, Patricia/F-4897-2014; Lahti,
   Jari/P-7987-2018; von Bonsdorff, Mikaela/A-5218-2015
OI Silveira, Patricia/0000-0001-8626-2519; Wasenius,
   Niko/0000-0002-9007-6660; Lahti, Jari/0000-0002-4310-5297; von
   Bonsdorff, Mikaela/0000-0001-8530-5230
FU Finnish Foundation for Cardiovascular Research; Finnish Foundation for
   Diabetes Research; Juho Vainio Foundation; Academy of Finland; Novo
   Nordisk Foundation; Signe and Ane Gyllenberg Foundation; Samfundet
   Folkhalsan; Finska Lakaresallskapet; Liv och Halsa; European Commission
   [278603]; EU H2020-PHC-2014-DynaHealth Grant [633595]; EU Horizon 2020
   Award [733206 LIFECYCLE]; Canadian Institutes of Health Research (CIHR)
   [PJT-166066]
FX The authors would like to express their gratitude to the participants in
   the Helsinki Birth Cohort Study. Also special thanks for the funding of
   the HBCS to the Finnish Foundation for Cardiovascular Research, Finnish
   Foundation for Diabetes Research, Juho Vainio Foundation, Academy of
   Finland, Novo Nordisk Foundation, Signe and Ane Gyllenberg Foundation,
   Samfundet Folkhalsan, Finska Lakaresallskapet, Liv och Halsa, European
   Commission FP7 (DORIAN) Grant Agreement No. 278603 and EU
   H2020-PHC-2014-DynaHealth Grant No. 633595 and EU Horizon 2020 Award
   733206 LIFECYCLE. Silveira PP is supported by Canadian Institutes of
   Health Research (CIHR, PJT-166066, PI Silveira PP).
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NR 51
TC 7
Z9 7
U1 1
U2 2
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD NOV 3
PY 2021
VL 11
IS 1
AR 21588
DI 10.1038/s41598-021-00631-w
PG 10
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA WR3PJ
UT WOS:000714415600031
PM 34732766
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Macki, M
   Hamilton, T
   Lim, S
   Telemi, E
   Bazydlo, M
   Nerenz, DR
   Zakaria, HM
   Schultz, L
   Khalil, JG
   Perez-Cruet, MJ
   Aleem, IS
   Park, P
   Schwalb, JM
   Abdulhak, MM
   Chang, V
AF Macki, Mohamed
   Hamilton, Travis
   Lim, Seokchun
   Telemi, Edvin
   Bazydlo, Michael
   Nerenz, David R.
   Zakaria, Hesham Mostafa
   Schultz, Lonni
   Khalil, Jad G.
   Perez-Cruet, Miguelangelo J.
   Aleem, Ilyas S.
   Park, Paul
   Schwalb, Jason M.
   Abdulhak, Muwaffak M.
   Chang, Victor
TI Disparities in outcomes after spine surgery: a Michigan Spine Surgery
   Improvement Collaborative study
SO JOURNAL OF NEUROSURGERY-SPINE
LA English
DT Article
DE African American; disparity; lumbar; race; satisfaction
ID AFRICAN-AMERICANS; ETHNIC DISPARITIES; METABOLIC SYNDROME; PATIENT
   OUTCOMES; NATIONAL-SURVEY; CHRONIC PAIN; DEPRESSION; WHITE; RACE;
   OSTEOARTHRITIS
AB OBJECTIVE Most studies on racial disparities in spine surgery lack data granularity to control for both comorbidities and self-assessment metrics. Analyses from large, multicenter surgical registries can provide an enhanced platform for understanding different factors that influence outcome. In this study, the authors aimed to determine the effects of race on outcomes after lumbar surgery, using patient-reported outcomes (PROs) in 3 areas: the North American Spine Society patient satisfaction index, the minimal clinically important difference (MCID) on the Oswestry Disability Index (ODI) for low-back pain, and return to work.
   METHODS The Michigan Spine Surgery Improvement Collaborative was queried for all elective lumbar operations. Patient race/ethnicity was categorized as Caucasian, African American, and "other." Measures of association between race and PROs were calculated with generalized estimating equations (GEEs) to report adjusted risk ratios.
   RESULTS The African American cohort consisted of a greater proportion of women with the highest comorbidity burden. Among the 7980 and 4222 patients followed up at 1 and 2 years postoperatively, respectively, African American patients experienced the lowest rates of satisfaction, MCID on ODI, and return to work. Following a GEE, African American race decreased the probability of satisfaction at both 1 and 2 years postoperatively. Race did not affect return to work or achieving MCID on the ODI. The variable of greatest association with all 3 PROs at both follow-up times was postoperative depression.
   CONCLUSIONS While a complex myriad of socioeconomic factors interplay between race and surgical success, the authors identified modifiable risk factors, specifically depression, that may improve PROs among African American patients after elective lumbar spine surgery.
C1 [Macki, Mohamed; Hamilton, Travis; Lim, Seokchun; Telemi, Edvin; Bazydlo, Michael; Nerenz, David R.; Zakaria, Hesham Mostafa; Schultz, Lonni; Schwalb, Jason M.; Abdulhak, Muwaffak M.; Chang, Victor] Henry Ford Hosp, Dept Neurosurg, Detroit, MI 48202 USA.
   [Khalil, Jad G.] Beaumont Hlth Syst, Dept Orthopaed Surg, Royal Oak, MI USA.
   [Perez-Cruet, Miguelangelo J.] Beaumont Hlth Syst, Dept Neurosurg, Royal Oak, MI USA.
   [Aleem, Ilyas S.] Univ Michigan Hosp, Dept Orthopaed Surg, Ann Arbor, MI 48109 USA.
   [Park, Paul] Univ Michigan Hosp, Dept Neurosurg, Ann Arbor, MI 48109 USA.
C3 Henry Ford Health System; Henry Ford Hospital; Beaumont Health; Beaumont
   Health; University of Michigan System; University of Michigan;
   University of Michigan System; University of Michigan
RP Chang, V (corresponding author), Henry Ford Hosp, Detroit, MI 48202 USA.
EM vchangl@hfhs.org
RI Park, Paul/AGX-0276-2022; Schwalb, Jason/AAQ-4932-2021
OI Park, Paul/0000-0002-0375-396X
FU Stryker; Medtronic; Johnson Johnson; Centinel Spine; Relievant;
   Limiflex; Fziomed
FX Dr. Khalil: direct stock ownership in Medtronic, NuVasive, and Johnson &
   Johnson; consultant for Stryker, Medtronic, Camber Spine, Centinel
   Spine, and Relievant Medsystems; and clinical or research support for
   the study described from Stryker, Medtronic, Johnson & Johnson, Centinel
   Spine, Relievant, Limiflex, and Fziomed. Dr. Perez-Cruet: ownership in
   Thompson MIS. Dr. Park: consultant for Globus and NuVasive; royalties
   from Globus; and support of non-study-related clinical or research
   effort from ISSG and DePuy. Dr. Schwalb: support of non-study-related
   clinical or research effort from Medtronic, StimWave, and Neuros;
   consultant for BlueRock and Guidant; and salary support for role as
   co-director of MSSIC (paid directly to Henry Ford Health System). Dr.
   Abdulhak: consultant for SeaSpine and Ulrich Medical. Dr. Chang:
   consultant for Globus Medical, K2M, and SpineGuard; and research funding
   from Medtronic. Although Blue Cross Blue Shield of Michigan (BCBSM) and
   MSSIC work collaboratively, the opinions, beliefs, and viewpoints
   expressed by the authors do not necessarily reflect the opinions,
   beliefs, and viewpoints of BCBSM or any of its employees. Support for
   MSSIC is provided by BCBSM and Blue Care Network as part of the BCBSM
   Value Partnerships program.
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NR 35
TC 8
Z9 8
U1 0
U2 1
PU AMER ASSOC NEUROLOGICAL SURGEONS
PI ROLLING MEADOWS
PA 5550 MEADOWBROOK DRIVE, ROLLING MEADOWS, IL 60008 USA
SN 1547-5654
EI 1547-5646
J9 J NEUROSURG-SPINE
JI J. Neurosurg.-Spine
PD JUL
PY 2020
VL 35
IS 1
BP 91
EP 99
DI 10.3171/2020.10.SPINE20914
PG 9
WC Clinical Neurology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Surgery
GA TH1CZ
UT WOS:000671833400004
PM 33962387
DA 2025-06-11
ER

PT J
AU Leyns, C
   Ascarrunz, C
   Rasguido, S
   Rodriguez, P
   Eid, D
   Guitian, J
AF Leyns, Christine
   Ascarrunz, Carla
   Rasguido, Shirley
   Rodriguez, Patricia
   Eid, Daniel
   Guitian, Javier
TI Engaging communities in health promotion through community-based primary
   care and participatory research during the COVID-19 pandemic in Bolivia
SO ARCHIVES OF MEDICAL RESEARCH
LA English
DT Article
DE Primary health care; Universal health care; Health equity; COVID-19
   pandemic; Bo- livia; Health care system
ID ORIENTED PRIMARY-CARE
AB Background. Most people in low- and middle-income countries work in the informal sector and lack social protection. In Bolivia, the unified family, community, and intercultural health model established universal health coverage for informal workers and their families in 2019. The COVID-19 pandemic, which occurred soon after, exposed both the vulnerabilities and the strengths of this health policy. Aim. To describe the community-based design of a health promotion strategy based on people-centered and participatory research within a vulnerable community of informal market vendors during the COVID-19 pandemic. Methods. As part of participatory action research during the COVID-19 pandemic, market vendors collaborated with a multidisciplinary research team, local authorities, and the health network to promote health and safety in their markets. Market vendors developed a health promotion strategy facilitated by a highly structured mixed qualitative- quantitative concept mapping approach and reached a consensus on an operational health strategy with measurable goals, actions, timelines, and actors. Results. A community health diagnosis together with health education and individualized clinical care, created a common understanding of health and built trust between the community and the research/health team. Market vendors identified health needs related to care access, self-care, market organization, and the social determinants of health, including strategies to prevent infections, reduce cardiometabolic risk, and improve mental health. Conclusions. Effective strategies to promote health or to manage health crises such as a pandemic can be developed by organized communities in primary care supported by individual and collective health data, health education, and the integration of social scientists, epidemiologists, and health professionals. (c) 2025 The Authors. Published by Elsevier Inc. on behalf of Instituto Mexicano del Seguro Social (IMSS). This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)
C1 [Leyns, Christine; Ascarrunz, Carla; Rasguido, Shirley; Guitian, Javier] Univ Mayor San Simon, Fac Ciencias Sociales, Inst Invest Ciencias Sociales, Cochabamba, Bolivia.
   [Leyns, Christine] Univ Ghent, Fac Med & Hlth Sci, Dept Publ Hlth & Primary Care, Ghent, Belgium.
   [Eid, Daniel] Univ Mayor San Simon, Fac Med, Inst Biomed Res & Social Res, Cochabamba, Bolivia.
   [Guitian, Javier] UNIV LONDON, Royal Vet Coll, HATFIELD, Hertford, England.
C3 Universidad Mayor de San Simon; Ghent University; Ghent University
   Hospital; Universidad Mayor de San Simon; University of London;
   University of London Royal Veterinary College
RP Guitian, J (corresponding author), UNIV LONDON, Royal Vet Coll, HATFIELD, Hertford, England.; Guitian, J (corresponding author), Royal Vet Coll, Hawkshead Lane, Hatfield AL9 7TA, Hertford, England.
EM jguitian@rvc.ac.uk
RI Leyns, Christine/A-3778-2012; Guitian, Javier/O-1185-2019; Eid,
   Daniel/AAD-8625-2019; Guitian, Javier/C-3022-2009
OI Eid, Daniel/0000-0001-8145-0967; Guitian, Javier/0000-0003-0799-0476
FU Medical Research Council; National Institute for Health and Care
   Research (NIHR) [MR/V028561/1]
FX Funding This work was supported by the Medical Research Council and the
   National Institute for Health and Care Research (NIHR) [MR/V028561/1] .
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NR 54
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PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
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EI 1873-5487
J9 ARCH MED RES
JI Arch. Med. Res.
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UT WOS:001419696000001
PM 39893754
OA hybrid
DA 2025-06-11
ER

PT J
AU Shuel, F
   White, J
   Jones, M
   Gray, R
AF Shuel, Francis
   White, Jacquie
   Jones, Martin
   Gray, Richard
TI Using the serious mental illness health improvement profile [HIP] to
   identify physical problems in a cohort of community patients: A
   pragmatic case series evaluation
SO INTERNATIONAL JOURNAL OF NURSING STUDIES
LA English
DT Article
DE Nursing; Physical health; Schizophrenia; Bipolar disorder; Serious
   mental illness; HIP; Metabolic syndrome; Assessment
ID BREAST-CANCER; SCHIZOPHRENIA; ANTIPSYCHOTICS; RISK; DISEASE; CATIE
AB Background and objectives: The physical health of people with serious mental illness is a cause of growing concern to clinicians. Life expectancy in this population may be reduced by up to 25 years and patients often live with considerable physical morbidity that can dramatically reduce quality of life and contribute to social exclusion. This study sought to determine whether the serious mental illness health improvement profile [HIP], facilitated by mental health nurses [MHNs], has the clinical potential to identify physical morbidity and inform future evidence-based care.
   Design: Retrospective documentation audit and qualitative evaluation of patients' and clinicians' views about the use of the HIP in practice.
   Setting: A nurse-led outpatient medication management clinic, for community adult patients with serious mental illness in Scotland.
   Participants: 31 Community patients with serious mental illness seen in the clinic by 2 MHNs trained to use the HIP. All 31 patients, 9 MHNs, 4 consultant psychiatrists and 12 general practitioners [GPs] (primary care physicians) participated in the qualitative evaluation.
   Methods: A retrospective documentation audit of case notes for all patients where the HIP had been implemented. Semi-structured interviews with patients and their secondary care clinicians. Postal survey of GPs.
   Results: 189 Physical health issues were identified (mean 6,1 per patient). Items most frequently flagged 'red', suggesting that intervention was required, were body mass index [BMI] (n = 24), breast self-examination (n = 23), waist circumference (n = 21), pulse (n = 14) and diet (n = 13). Some rates of physical health problems observed were broadly similar to those reported in studies of patients receiving antipsychotics in primary care but much lower than those reported in epidemiological studies. Individualised care was planned and delivered with each patient based on the profile. 28 discreet interventions that included providing advice, promoting health behavioural change, performing an electrocardiogram and making a referral to professional colleagues were used. Qualitative feedback was positive. Our observations support the use of the HIP in clinical settings to enhance mental health nursing practice; however, we strongly recommend that training is required to support the use of the HIP. (C) 2009 Elsevier Ltd. All rights reserved.
C1 [White, Jacquie] Univ Hull, Fac Hlth & Social Care, Kingston Upon Hull HU6 7RX, N Humberside, England.
   [Jones, Martin] Surrey & Borders Partnership NHS Fdn Trust, Surrey, England.
   [Gray, Richard] Univ E Anglia, Fac Hlth, Norwich NR4 7TJ, Norfolk, England.
C3 University of Hull; University of East Anglia
RP White, J (corresponding author), Univ Hull, Fac Hlth & Social Care, 209 Dearne Bldg,Cottingham Rd, Kingston Upon Hull HU6 7RX, N Humberside, England.
EM jacqueline.white@hull.ac.uk
RI Jones, Martin/G-7810-2016; Gray, Richard/C-9945-2017; White,
   Jacquie/N-7287-2015
OI Jones, Martin/0000-0002-6463-3574; Gray, Richard/0000-0001-9694-4206;
   White, Jacquie/0000-0002-6196-2516
FU Bristol-Myers Squibb and Otzuka Pharmaceuticals Co, Ltd
FX The design of the study; i.e. the collection, analysis, and
   interpretation of data; the writing of the report and the decision to
   submit the paper for publication was made by the authors alone.
   Development and printing of the HIP and the funding of education
   workshops to educate nurses in how to use the HIP was supported by
   Bristol-Myers Squibb and Otzuka Pharmaceuticals Co, Ltd. as a service to
   medicine and has been described elsewhere (White et al., 2009).
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NR 34
TC 59
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U2 23
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0020-7489
EI 1873-491X
J9 INT J NURS STUD
JI Int. J. Nurs. Stud.
PD FEB
PY 2010
VL 47
IS 2
BP 136
EP 145
DI 10.1016/j.ijnurstu.2009.06.003
PG 10
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA 561JF
UT WOS:000274971500002
PM 19596322
DA 2025-06-11
ER

PT J
AU Stener-Victorin, E
   Zhang, HL
   Li, R
   Friden, C
   Li, D
   Wang, W
   Wang, HN
   Chang, CQ
   Li, S
   Huo, ZJ
   Zhang, H
   Ji, XL
   Linden-Hirschberg, A
   Qiao, J
AF Stener-Victorin, Elisabet
   Zhang, Haolin
   Li, Rong
   Friden, Cecilia
   Li, Dong
   Wang, Wei
   Wang, Haining
   Chang, Cuiqing
   Li, Shi
   Huo, Zejun
   Zhang, Hua
   Ji, Xiaolan
   Linden-Hirschberg, Angelica
   Qiao, Jie
TI Acupuncture or metformin to improve insulin resistance in women with
   polycystic ovary syndrome: study protocol of a combined multinational
   cross sectional case-control study and a randomised controlled trial
SO BMJ OPEN
LA English
DT Article
ID QUALITY-OF-LIFE; METABOLIC SYNDROME; DNA METHYLATION; ADIPOSE-TISSUE;
   RATING-SCALE; OBESE WOMEN; DEPRESSION; ANXIETY; QUESTIONNAIRE;
   HYPERANDROGENISM
AB Introduction Polycystic ovary syndrome (PCOS) is linked to hyperinsulinemia and insulin resistance with dysfunctional glucose metabolism. Pilot studies suggests that acupuncture treatment with combined manual and low-frequency electrical stimulation (electroacupuncture (EA)) of the needles decrease circulating glycated haemoglobulin (HbA1c) and homeostatic model assessment-insulin resistance. Therefore, we here aim to investigate if acupuncture treatment or metformin together with lifestyle or lifestyle management alone improves insulin sensitivity and related symptoms in overweight/obese women with PCOS.
   Methods and analysis This is a two-centre multinational (Sweden and China), cross-sectional case-control study combined with an open-labelled randomised controlled trial (RCT). Participants are randomised to one of three groups: (1) EA 2-3 times/week during 4 months+lifestyle management; (2) metformin, 500 mg, three/day during 4 months+lifestyle management; or (3) lifestyle management alone. The primary outcome measure in the RCT is changes in HbA1C. A total of 123 obese overweight women with PCOS will be enrolled and randomised into one of the three groups with a target power of at least 80% and 5% significance level based on two-sided tests.
   Ethics and dissemination The study has been approved by the Regional Ethical Review Board of Stockholm and of Peking University Third Hospital, China. Primary outcome data of the RCT will be published in a relevant journal together with supporting secondary outcome measurements. Further, outcome measurements will be published in separate papers as well as case-control data.
   Expected results We anticipate that EA and metformin, both with lifestyle management, are equally effective and superior to lifestyle management alone for improvement of glycaemic control.
C1 [Stener-Victorin, Elisabet] Karolinska Inst, Dept Physiol & Pharmacol, Stockholm, Sweden.
   [Zhang, Haolin; Li, Dong; Huo, Zejun; Ji, Xiaolan] Peking Univ, Dept Tradit Chinese Med TCM, Hosp 3, Beijing, Peoples R China.
   [Li, Rong; Li, Shi; Qiao, Jie] Peking Univ, Dept Obstet & Gynecol, Hosp 3, Ctr Reprod Med, Beijing, Peoples R China.
   [Li, Rong; Wang, Wei; Qiao, Jie] Peking Univ, Dept Obstet & Gynecol, Hosp 3, Beijing, Peoples R China.
   [Friden, Cecilia] Karolinska Inst, Div Physiotherapy, Dept Neurobiol, Care Sci & Soc, Huddinge, Sweden.
   [Wang, Haining] Peking Univ, Dept Endocrinol & Metab, Hosp 3, Beijing, Peoples R China.
   [Chang, Cuiqing] Peking Univ, Hosp 3, Inst Sports Med, Beijing, Peoples R China.
   [Zhang, Hua] Peking Univ, Hosp 3, Res Ctr Clin Epidemiol, Beijing, Peoples R China.
   [Linden-Hirschberg, Angelica] Karolinska Inst, Dept Obstet & Gynecol, Stockholm, Sweden.
C3 Karolinska Institutet; Peking University; Peking University; Peking
   University; Karolinska Institutet; Peking University; Peking University;
   Peking University; Karolinska Institutet
RP Stener-Victorin, E (corresponding author), Karolinska Inst, Dept Physiol & Pharmacol, Stockholm, Sweden.
EM elisabet.stener-victorin@ki.se
RI Li, Shijun/AAK-7225-2021; , Cecilia/HJA-1367-2022; Stener-Victorin,
   Elisabet/W-6322-2018; zhang, haolin/L-8632-2018
OI Friden, Cecilia/0000-0002-6989-719X; Stener-Victorin,
   Elisabet/0000-0002-3424-1502; Hirschberg, Angelica
   Linden/0000-0001-6481-6277; zhang, haolin/0000-0002-9679-5850
FU Swedish Medical Research Council [2018-0243599]; Adlerbert Research
   Foundation; Novo Nordisk Foundation [NNF18OC0033992]; Strategic Research
   Programme (SRP) in Diabetes at Karolinska Institutet; Stockholm County
   Council; Karolinska Institutet; National Key Research and Development
   Program [2016YFC100021]; National Key Technology RD Program
   [2015BAI13B06, 2014BAI05B04]; National Natural Science Foundation of
   China [81603446]; Beijing Municipal Natural Science Foundation [7174363]
FX The work is supported by the Swedish Medical Research Council (Project
   No. 2018-0243599; Adlerbert Research Foundation; Novo Nordisk Foundation
   (NNF18OC0033992); Strategic Research Programme (SRP) in Diabetes at
   Karolinska Institutet; Swedish federal government under the Regional
   agreement on medical training and clinical research (ALF) between
   Stockholm County Council and Karolinska Institutet (all ESV). In China,
   this study is supported by the National Key Research and Development
   Program (2016YFC100021), National Key Technology R&D Program
   (2015BAI13B06, 2014BAI05B04), National Natural Science Foundation of
   China (81603446), Beijing Municipal Natural Science Foundation
   (7174363).
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NR 53
TC 15
Z9 17
U1 3
U2 33
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2044-6055
J9 BMJ OPEN
JI BMJ Open
PD JUN
PY 2019
VL 9
IS 1
AR e024733
DI 10.1136/bmjopen-2018-024733
PG 10
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA IC6XU
UT WOS:000471116800201
PM 30612112
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Horigome, A
   Okubo, R
   Hamazaki, K
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AF Horigome, A.
   Okubo, R.
   Hamazaki, K.
   Kinoshita, T.
   Katsumata, N.
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TI Association between blood omega-3 polyunsaturated fatty acids and the
   gut microbiota among breast cancer survivors
SO BENEFICIAL MICROBES
LA English
DT Article
DE DHA; EPA; gut microbiota; Bifidobacterium
ID MURINE; LIPIDS; LIVER; MEAT
AB Omega-3 polyunsaturated fatty acids (PUFAs) are essential nutrients demonstrated to have health benefits, such as decreasing the risk of coronary heart disease, improving parameters associated with metabolic syndrome, and decreasing anxiety symptoms and depression risk. Previous intervention studies indicated the association between blood or tissue PUFA levels and the gut microbiota; however, the details remain incompletely elucidated. We conducted a cross-sectional study to examine the association between PUFAs and the gut microbiota among breast cancer survivors. Adults who had been diagnosed with invasive breast cancer more than one year ago and were not currently undergoing chemotherapy were enrolled. Capillary blood and faecal samples were obtained to assess the blood PUFA levels and gut microbiota compositions. The mean age (n=124) was 58.7 years, and 46% of the participants had a history of chemotherapy. Multiple regression analysis controlling for possible confounders indicated that an increased relative abundance of Actinobacteria was significantly associated with increased levels of docosahexaenoic acid (DHA, beta=0.304, q<0.01). At the genus level, the abundance of Bifidobacterium was positively associated with the level of DHA (beta=0.307, q<0.01). No significant association between omega-6 PUFAs and the relative abundances of gut microbiota members was observed. In addition, analyses stratified by the history of chemotherapy indicated significant associations of PUFA levels with the abundance of some bacterial taxa, including the phylum Actinobacteria (DHA, beta=0.365, q<0.01) and Bacteroidetes (EPA, beta=-0.339, q<0.01) and the genus Bifidobacterium (DHA, beta=0.368, q<0.01) only among participants without a history of chemotherapy. These findings provide the first evidence of positive associations between the abundances of Bifidobacterium among the gut microbiota and the levels of omega-3 PUFAs in the blood. Further studies are required to gain additional insight into these associations in healthy subjects as well as into the causality of the relationship.
C1 [Horigome, A.; Katsumata, N.; Xiao, J. Z.] Morinaga Milk Ind Co Ltd, Next Generat Sci Inst, 5-1-83 Higashihara, Zama, Kanagawa 2528583, Japan.
   [Okubo, R.; Matsuoka, Y. J.] Natl Canc Ctr Japan, Ctr Publ Hlth Sci, Div Hlth Care Res, Chuo Ku, 5-1-1 Tsukiji, Tokyo 1040045, Japan.
   [Hamazaki, K.] Univ Toyama, Dept Publ Hlth, Fac Med, 2630 Sugitani, Toyama, Toyama 9300194, Japan.
   [Kinoshita, T.] Natl Canc Ctr, Dept Breast Surg, Chuo Ku, 5-1-1 Tsukiji, Tokyo 1040045, Japan.
   [Uezono, Y.] Natl Canc Ctr, Div Canc Pathophysiol, Chuo Ku, 5-1-1 Tsukiji, Tokyo 1040045, Japan.
C3 Morinaga Milk Industry Company, Ltd; National Cancer Center - Japan;
   University of Toyama; National Cancer Center - Japan; National Cancer
   Center - Japan
RP Xiao, JZ (corresponding author), Morinaga Milk Ind Co Ltd, Next Generat Sci Inst, 5-1-83 Higashihara, Zama, Kanagawa 2528583, Japan.; Matsuoka, YJ (corresponding author), Natl Canc Ctr Japan, Ctr Publ Hlth Sci, Div Hlth Care Res, Chuo Ku, 5-1-1 Tsukiji, Tokyo 1040045, Japan.
EM j_xiao@morinagamilk.co.jp; yumatsuo@ncc.go.jp
RI Matsuoka, Yutaka/LEM-8619-2024; Xiao, Jinzhong/HIR-9791-2022; Kinoshita,
   Takayuki/AAA-5722-2020
FU Japan Society for the Promotion of Science [17H04253]; Grants-in-Aid for
   Scientific Research [17H04253] Funding Source: KAKEN
FX A Grant-in-Aid for Scientific Research B from the Japan Society for the
   Promotion of Science (No. 17H04253) and a research grant for cancer
   survivorship from the Foundation for Promotion of Cancer Research were
   used for the payment of research assistants and the writing and editing
   of the manuscript.
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NR 37
TC 31
Z9 33
U1 1
U2 22
PU WAGENINGEN ACADEMIC PUBLISHERS
PI WAGENINGEN
PA PO BOX 220, WAGENINGEN, 6700 AE, NETHERLANDS
SN 1876-2883
EI 1876-2891
J9 BENEF MICROBES
JI Benef. Mirbobes
PY 2019
VL 10
IS 7
BP 751
EP 758
DI 10.3920/BM2019.0034
PG 8
WC Microbiology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Microbiology; Nutrition & Dietetics
GA JD4IF
UT WOS:000489939400005
PM 31965846
DA 2025-06-11
ER

PT J
AU He, S
   Yu, Y
   Chen, PQ
   Sun, HM
   Gao, XR
   Sun, HZ
   Ge, JF
AF He, Shuai
   Yu, Yue
   Chen, Peng-quan
   Sun, Hui-min
   Gao, Xin-ran
   Sun, Huai-zhi
   Ge, Jin-fang
TI Insufficient Plasma Melatonin and Its Association With Neuropsychiatric
   Impairments in Patients With T2DM
SO JOURNAL OF DIABETES RESEARCH
LA English
DT Article
DE metabolic syndrome; MLT; neuroinflammation; neuropsychiatric
   impairments; T2DM
ID BRAIN INSULIN-RESISTANCE; ALZHEIMERS-DISEASE; DIABETES-MELLITUS; TYPE-2;
   RISK; DEPRESSION
AB Purpose: Type 2 diabetes mellitus (T2DM) is associated with multiple neuropsychiatric impairments, including cognitive dysfunction, and melatonin (MLT) plays a crucial role in maintaining normal neuropsychiatric functions. This study is aimed at investigating the change in plasma MLT levels and its association with neuropsychiatric impairments in T2DM patients.Methods: One hundred twenty-six T2DM patients were recruited, and their demographics and clinical data were collected. Apart from the plasma glycated hemoglobin (HbA1c) levels and other routine metabolic indicators, the plasma concentrations of MLT, C-reactive protein (CRP), Interleukin 6 (IL-6), soluble myeloid triggered receptor 1 (sTREM 1), and receptor 2 (sTREM 2) were measured. Moreover, the executive function and depressive tendency were evaluated via the Behavior Rating Inventory of Executive Function-Adult Version (BRIEF-A) and the Epidemiological Research Center Depression Scale (CES-D), respectively.Result: Compared with the low HbA1c group, the T2DM patients in the high HbA1c group presented lower plasma MLT levels but higher plasma concentrations of inflammatory biomarker levels, together with higher scores in the BRIEF-A and CES-D scales. Moreover, results of the Pearson correlation test showed that the plasma MLT levels were negatively correlated with the BRIEF-A and CES-D scores, as well as plasma concentrations of HbA1c and inflammatory indications, indicating that MLT may mediate their neuroinflammation and neuropsychiatric impairments. Furthermore, the ROC curve results indicated that plasma MLT levels have a predictive effect on executive impairment and depressive status in T2DM patients.Conclusion: MLT levels decreased in patients with T2DM and were associated with neuropsychiatric impairments and inflammatory status, and MLT might be developed as a therapeutic agent and predictive indicator for T2DM-associated executive impairment and depression status.
C1 [He, Shuai; Chen, Peng-quan; Sun, Hui-min; Gao, Xin-ran; Sun, Huai-zhi; Ge, Jin-fang] Anhui Med Univ, Sch Pharm, 81 Mei Shan Rd, Hefei 230032, Peoples R China.
   [He, Shuai; Chen, Peng-quan; Sun, Hui-min; Gao, Xin-ran; Sun, Huai-zhi; Ge, Jin-fang] Anhui Med Univ, Key Lab Antiinflammatory & Immune Med, Minist Educ, Hefei, Peoples R China.
   [He, Shuai; Chen, Peng-quan; Sun, Hui-min; Gao, Xin-ran; Sun, Huai-zhi; Ge, Jin-fang] Anhui Inst Innovat Drugs, Anhui Prov Lab Inflammatory & Immun Dis, Hefei, Peoples R China.
   [Yu, Yue] Anhui Med Univ, Dept Pharm, North Dist Affiliated Hosp 1, Hefei, Peoples R China.
C3 Anhui Medical University; Ministry of Education - China; Anhui Medical
   University; Anhui Medical University
RP Ge, JF (corresponding author), Anhui Med Univ, Sch Pharm, 81 Mei Shan Rd, Hefei 230032, Peoples R China.; Ge, JF (corresponding author), Anhui Med Univ, Key Lab Antiinflammatory & Immune Med, Minist Educ, Hefei, Peoples R China.; Ge, JF (corresponding author), Anhui Inst Innovat Drugs, Anhui Prov Lab Inflammatory & Immun Dis, Hefei, Peoples R China.
EM heshuai0822@163.com; ladyy916@163.com; 2219617261@qq.com;
   sunhuimin199902@163.com; gaoxinran1105@163.com; 2670476627@qq.com;
   gejinfang@ahmu.edu.cn
OI Ge, Jin-fang/0000-0002-6289-9934
FU Anhui Medical University
FX We are grateful to the staff of the North District Pharmacy Department
   of the First Affiliated Hospital of Anhui Medical University for their
   assistance in collecting patient data and blood collection.
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NR 49
TC 3
Z9 3
U1 0
U2 0
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2314-6745
EI 2314-6753
J9 J DIABETES RES
JI J. Diabetes Res.
PD JUL 3
PY 2024
VL 2024
AR 5661751
DI 10.1155/2024/5661751
PG 13
WC Endocrinology & Metabolism; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Research & Experimental Medicine
GA YU5L4
UT WOS:001271011300001
PM 38988702
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Franco, FGD
   Laurinavicius, AG
   Lotufo, PA
   Conceiçao, RD
   Morita, F
   Katz, M
   Wajngarten, M
   Carvalho, JAM
   Bosworth, HB
   Santos, RD
AF de Mello Franco, Fabio Gazelato
   Laurinavicius, Antonio Gabriele
   Lotufo, Paulo A.
   Conceicao, Raquel D.
   Morita, Fernando
   Katz, Marcelo
   Wajngarten, Mauricio
   Maluf Carvalho, Jose Antonio
   Bosworth, Hayden B.
   Santos, Raul Dias
TI Persistent Depressive Symptoms are Independent Predictors of Low-Grade
   Inflammation Onset Among Healthy Individuals
SO ARQUIVOS BRASILEIROS DE CARDIOLOGIA
LA English
DT Article
DE Depression; Cardiovascular Diseases; Inflammation; Patient Selection
ID C-REACTIVE PROTEIN; CORONARY-HEART-DISEASE; PHYSICAL-ACTIVITY; RISK;
   RELIABILITY; ASSOCIATION; BEHAVIORS; ACCURACY; MARKERS; GENDER
AB Background: Depressive symptoms are independently associated with an increased risk of cardiovascular disease (CVD) among individuals with non-diagnosed CVD. The mechanisms underlying this association, however, remain unclear. Inflammation has been indicated as a possible mechanistic link between depression and CVD.
   Objectives: This study evaluated the association between persistent depressive symptoms and the onset of low-grade inflammation.
   Methods: From a database of 1,508 young (mean age: 41 years) individuals with no CVD diagnosis who underwent at least two routine health evaluations, 134 had persistent depressive symptoms (Beck Depression Inventory -BDI >= 10, BDI+) and 1,374 had negative symptoms at both time points (BDI-). All participants had been submitted to repeated clinical and laboratory evaluations at a regular follow-up with an average of 26 months from baseline. Low-grade inflammation was defined as plasma high-sensitivity C-Reactive Protein (CRP) concentrations > 3 mg/L. The outcome was the incidence of low-grade inflammation evaluated by the time of the second clinical evaluation.
   Results: The incidence of low-grade inflammation was more frequently observed in the BDI+ group compared to the BDI-group (20.9% vs. 11.4%; p = 0.001). After adjusting for sex, age, waist circumference, body mass index, levels of physical activity, smoking, and prevalence of metabolic syndrome, persistent depressive symptoms remained an independent predictor of low-grade inflammation onset (OR = 1.76; 95% CI: 1.03-3.02; p = 0.04).
   Conclusions: Persistent depressive symptoms were independently associated with low-grade inflammation onset among healthy individuals.
C1 [de Mello Franco, Fabio Gazelato; Morita, Fernando; Katz, Marcelo; Wajngarten, Mauricio; Maluf Carvalho, Jose Antonio] Hosp Israelita Albert Einstein, Sao Paulo, SP, Brazil.
   [Laurinavicius, Antonio Gabriele; Conceicao, Raquel D.; Santos, Raul Dias] Hosp Israelita Albert Einstein, Ctr Med Prevent, Sao Paulo, SP, Brazil.
   [Laurinavicius, Antonio Gabriele; Conceicao, Raquel D.; Santos, Raul Dias] Hosp Israelita Albert Einstein, Programa Cardiol, Sao Paulo, SP, Brazil.
   [Lotufo, Paulo A.] Univ Sao Paulo, Ctr Pesquisa Clin & Epidemiol, Sao Paulo, SP, Brazil.
   [Santos, Raul Dias] Univ Sao Paulo, Unidade Clin Lipides, Inst Coracao InCor, Hosp Clin,Fac Med, Sao Paulo, SP, Brazil.
   [Bosworth, Hayden B.] Duke Univ, Med Ctr, Durham, NC 27706 USA.
C3 Hospital Israelita Albert Einstein; Hospital Israelita Albert Einstein;
   Hospital Israelita Albert Einstein; Universidade de Sao Paulo;
   Universidade de Sao Paulo; Duke University
RP Franco, FGD (corresponding author), Rua Coronel Lisboa 139, BR-04020040 Mariana, SP, Brazil.
EM ffranco@einstein.br
RI Santos, Raul/A-1170-2010; Lotufo, Paulo/A-9843-2008
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NR 31
TC 10
Z9 11
U1 0
U2 4
PU ARQUIVOS BRASILEIROS CARDIOLOGIA
PI RIO DE JANEIRO
PA AVENIDA MARECHAL CAMARA 160-330 CENTRO, RIO DE JANEIRO, RJ 20 020-907,
   BRAZIL
SN 0066-782X
J9 ARQ BRAS CARDIOL
JI Arq. Bras. Cardiol.
PD AUG
PY 2017
VL 109
IS 2
BP 103
EP 108
DI 10.5935/abc.20170080
PG 6
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA FG9QY
UT WOS:000410775300003
PM 28678924
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Russo, G
   Di Franco, A
   Lamendola, P
   Tarzia, P
   Nerla, R
   Stazi, A
   Villano, A
   Sestito, A
   Lanza, GA
   Crea, F
AF Russo, Giulio
   Di Franco, Antonino
   Lamendola, Priscilla
   Tarzia, Pierpaolo
   Nerla, Roberto
   Stazi, Alessandra
   Villano, Angelo
   Sestito, Alfonso
   Lanza, Gaetano A.
   Crea, Filippo
TI Lack of Effect of Nitrates on Exercise Stress Test Results in Patients
   with Microvascular Angina
SO CARDIOVASCULAR DRUGS AND THERAPY
LA English
DT Article
DE Microvascular angina; Exercise stress test; Nitrates; Coronary
   microvascular dysfunction
ID NORMAL CORONARY-ARTERIES; CARDIAC SYNDROME-X; HEART-DISEASE; FLOW
   RESERVE; PECTORIS; DOPPLER; NITROGLYCERIN; DYSFUNCTION; ULTRASOUND;
   MANAGEMENT
AB To assess the effects of short-acting nitrates on exercise stress test (EST) results and the relation between EST results and coronary blood flow (CBF) response to nitrates in patients with microvascular angina (MVA).
   We completed 2 symptom/sign limited ESTs on 2 separate days, in a random sequence and in pharmacological washout, in 29 MVA patients and in 24 patients with obstructive coronary artery disease (CAD): one EST was performed without any intervention (control EST, C-EST), and the other after sublingual isosorbide dinitrate, 5 mg (nitrate EST, N-EST). CBF response to nitroglycerin (25 mu g) was assessed in the left anterior descending coronary artery by transthoracic Doppler-echocardiography.
   At C-EST. ST-segment depression a parts per thousand yen1 mm (STD) was induced in 26 (90 %) and 23 (96 %) MVA and CAD patients, respectively (p = 0.42), whereas at N-EST, STD was induced in 25 (86 %) and 14 (56 %) MVA and CAD patients, respectively (p = 0.01). Time and rate pressure product at 1 mm STD increased during N-EST, compared to C-EST, in CAD patients (475 +/- 115 vs. 365 +/- 146 s, p < 0.001; and 23511 +/- 4352 vs. 20583 +/- 6234 bpma <...mmHg, respectively, p = 0.01), but not in MVA patients (308 +/- 160 vs. 284 +/- 136 s; p = 0.19; and 21290 +/- 5438 vs. 20818 +/- 4286 bpma <...mmHg, respectively, p = 0.35). In MVA patients, a significant correlation was found between heart rate at STD during N-EST and CBF response to nitroglycerin (r = 0.40, p = 0.04).
   Short-acting nitrates improve EST results in CAD, but not in MVA patients. In MVA patients a lower nitrate-dependent coronary microvascular dilation may contribute to the lack of effects of nitrates on EST results.
C1 [Russo, Giulio; Di Franco, Antonino; Lamendola, Priscilla; Tarzia, Pierpaolo; Nerla, Roberto; Stazi, Alessandra; Villano, Angelo; Sestito, Alfonso; Lanza, Gaetano A.; Crea, Filippo] Univ Cattolica Sacro Cuore, Ist Cardiol, I-00168 Rome, Italy.
C3 Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli
RP Lanza, GA (corresponding author), Univ Cattolica Sacro Cuore, Ist Cardiol, Largo A Gemelli 8, I-00168 Rome, Italy.
EM g.a.lanza@rm.unicatt.it
RI Villano, Angelo/AAC-7245-2022; Tarzia, Pierpaolo/AAC-1593-2019; Russo,
   Giulio/AAB-3944-2019; Lanza, Gaetano/AAC-2660-2019; Nerla,
   Roberto/AAL-1534-2020; Crea, Filippo/AAC-9754-2022
OI Russo, Giulio/0000-0002-6302-0135; Villano, Angelo/0000-0003-1651-1369;
   Nerla, Roberto/0000-0002-9065-3261
CR Bugiardini R, 2005, JAMA-J AM MED ASSOC, V293, P477, DOI 10.1001/jama.293.4.477
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NR 23
TC 66
Z9 71
U1 0
U2 10
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0920-3206
J9 CARDIOVASC DRUG THER
JI Cardiovasc. Drugs Ther.
PD JUN
PY 2013
VL 27
IS 3
BP 229
EP 234
DI 10.1007/s10557-013-6439-z
PG 6
WC Cardiac & Cardiovascular Systems; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Pharmacology & Pharmacy
GA 140JE
UT WOS:000318649600007
PM 23338814
DA 2025-06-11
ER

PT J
AU Hishikawa, N
   Fukui, Y
   Sato, K
   Ohta, Y
   Yamashita, T
   Abe, K
AF Hishikawa, Nozomi
   Fukui, Yusuke
   Sato, Kota
   Ohta, Yasuyuki
   Yamashita, Toru
   Abe, Koji
TI Comprehensive effects of galantamine and cilostazol combination therapy
   on patientswith Alzheimer's disease with asymptomatic lacunar infarction
SO GERIATRICS & GERONTOLOGY INTERNATIONAL
LA English
DT Article
DE Alzheimer's disease; asymptomatic lacunar infarction; cilostazol;
   cognitive/affective functions,galantamine
ID CEREBRAL-BLOOD-FLOW; CEREBROVASCULAR-DISEASE; COGNITIVE IMPAIRMENT;
   METABOLIC SYNDROME; VASCULAR DEMENTIA; INHIBITOR; RISK
AB Aim: The coexistence of Alzheimer's disease (AD) and cerebrovascular disease pathology increases age-dependently. WC comprehensively analyzed the clinical effects of galantamine or cilostazol monotherapy to the add-on combination therapy on three major factors of dementia, such as cognitive, affective and activities of daily living functions in AD patients with asymptomatic lacunar infarction.
   Methods: We divided 101 AD patients with asymptomatic lacunar infarction into two subgroups: group A (a = 61, first treated with galantamine and then cilostazol added) and group B (n=40, first treated with cilostazol and galantamine added). We compared the clinical effects before and after combination therapy of galantamine and cilostazol. (i.e. 3 months [MI before (-3 M), baseline (0 M), 3 and 6 M after the add-on combination).
   Results: Galantamine monotherapy increased cognitive Hasegawa dementia score-revised scores, which were further improved with add-on cilostazol. Cilostazol monotherapy also increased the cognitive tests, which were further improved with add-on galantamine. Add-on cilostazol significantly improved Geriatric Depression Scale and Abe's behavioral and psychological symptoms of dementia scores after galantamine monotherapy. Cilostazol monotherapy also significantly improved Geriatric Depression Scale scores, with further improvements in Geriatric Depression Scale, apathy scores and Abe's behavioral and psychological symptoms of dementia scores by add-on galantamine. Activities of daily living scores continuously improved with galantamine monotherapy and add-on cilostazol.
   Conclusions: The present study provides a clinical possibility that galantamine or cilostazol monotherapy and the combination therapy maintained or even improved cognitive, affective, and activities of daily living functions in AD with asymptomatic lacunar infarction.
C1 [Hishikawa, Nozomi; Fukui, Yusuke; Sato, Kota; Ohta, Yasuyuki; Yamashita, Toru; Abe, Koji] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Neurol, Okayama, Japan.
C3 Okayama University
RP Abe, K (corresponding author), Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Neurol, Kita Ku, 2-5-1 Shikatacho, Okayama 7008558, Japan.
EM neuroabek@yahoo.co.jp
OI Yamashita, Toru/0000-0003-3634-5679
FU Ministry of Health, Labor and Welfare of Japan;  [2529320216]; 
   [24591263];  [24659651]
FX This work was partly supported by a Grant-in-Aid for Scientific Research
   (B) 2529320216, (C) 24591263 and Challenging Research 24659651, and by
   Grants-in-Aid from the Research Committees (H Mizusawa, K Nakashima, M
   Nishizawa, H Sasaki and M Aoki) from the Ministry of Health, Labor and
   Welfare of Japan.
CR Abe K, 2015, J NEUROL SCI, V350, P14, DOI 10.1016/j.jns.2015.01.029
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NR 30
TC 15
Z9 16
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1444-1586
EI 1447-0594
J9 GERIATR GERONTOL INT
JI Geriatr. Gerontol. Int.
PD OCT
PY 2017
VL 17
IS 10
BP 1384
EP 1391
DI 10.1111/ggi.12870
PG 8
WC Geriatrics & Gerontology; Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA FP2DR
UT WOS:000417426300004
PM 27578455
DA 2025-06-11
ER

PT J
AU Rafn, BS
   Andersen, MF
   Sorensen, V
   Bjerre, ED
   Baandrup, L
   Vernal, DL
   Mors, O
   Knop, FK
   Wolf, RT
   Tolver, A
   Firth, J
   Nohr, N
   Skou, ST
   Ebdrup, BH
   Midtgaard, J
AF Rafn, Bolette Skjodt
   Andersen, Martin Faerch
   Sorensen, Victor
   Bjerre, Eik Dybboe
   Baandrup, Lone
   Vernal, Ditte Lammers
   Mors, Ole
   Knop, Filip Krag
   Wolf, Rasmus Trap
   Tolver, Anders
   Firth, Joseph
   Nohr, Nikolaj
   Skou, Soren T.
   Ebdrup, Bjorn H.
   Midtgaard, Julie
TI Value of gym-based group exercise versus usual care for young adults
   receiving antipsychotic medication: study protocol for the multicenter
   randomized controlled Vega trial
SO BMC PSYCHIATRY
LA English
DT Article
DE Physical activity; Severe mental illness; Recovery; High-intensity
   Functional Training; Antipsychotics; Community; Loneliness;
   Stigmatization
ID SEVERE MENTAL-ILLNESS; CYCLE ERGOMETER TEST; METABOLIC SYNDROME;
   HEALTH-PROMOTION; WEIGHT-LOSS; SCHIZOPHRENIA; RECOVERY; PSYCHOSIS;
   VALIDITY; LIFE
AB Background Exercise is recommended to protect physical health among people with severe mental illness and holds the potential to facilitate long-term recovery. An inclusive exercise community provides an opportunity for life skill training and social connectedness and may reduce the experience of loneliness and internalized stigmatization which together may improve personal recovery. Using a pragmatic randomized design, we aim to examine the effectiveness of a gym-based exercise intervention tailored to young adults in antipsychotic treatment (i.e., Vega Exercise Community) compared to usual care. It is hypothesized that the Vega Exercise Community will be superior to usual care for personal recovery at four months.Methods The trial will be conducted at four sites in Denmark from which 400 participants, aged 18 to 35 years, who are in current treatment with antipsychotic medications for the management of schizophrenia spectrum or affective disorders, will be recruited. Participants will be randomized (2:1) to Vega Exercise Community or usual care. Vega Exercise Community includes three weekly group-based exercise sessions hosted in commercial functional training centers delivered by certified Vega instructors. After four months, participants in Vega Exercise Community will be randomized (1:1) to minimal versus extended support with regards to sustained physical activity. Data will be collected at baseline, four, six and 12 months. The primary outcome is personal recovery assessed by Questionnaire about the Process of Recovery at four months. Behavioral symptoms, health-related quality of life, metabolic health, and program costs will be evaluated to further determine the effectiveness and cost-effectiveness of the Vega Exercise Community. Finally, the quality of life and physical and mental health of the participants' primary relative will be evaluated.DiscussionThe results of this trial may have important implications for health, sustained physical activity, and recovery for individuals in treatment with antipsychotics. Given the pragmatic design, positive results may readily be implemented by mental health care professionals to promote exercise as an integrated part of treatment of severe mental illness.
C1 [Rafn, Bolette Skjodt; Andersen, Martin Faerch; Sorensen, Victor; Bjerre, Eik Dybboe; Wolf, Rasmus Trap; Nohr, Nikolaj; Midtgaard, Julie] Univ Copenhagen, Mental Hlth Ctr Glostrup, Ctr Appl Res Mental Hlth Care CARMEN, Glostrup, Denmark.
   [Rafn, Bolette Skjodt] Rigshosp, Dept Oncol, Danish Canc Soc Natl Canc Survivorship & Late Eff, Copenhagen Univ Hosp, Copenhagen, Denmark.
   [Andersen, Martin Faerch] Univ Coll Northern Denmark, Dept Physiotherapy, Aalborg, Denmark.
   [Sorensen, Victor; Baandrup, Lone; Ebdrup, Bjorn H.] Univ Copenhagen, Mental Hlth Ctr Glostrup, Ctr Neuropsychiat Schizophrenia Res CNSR, Copenhagen, Denmark.
   [Baandrup, Lone; Ebdrup, Bjorn H.] Mental Hlth Ctr Copenhagen, Copenhagen, Denmark.
   [Baandrup, Lone; Knop, Filip Krag; Ebdrup, Bjorn H.; Midtgaard, Julie] Univ Copenhagen, Fac Hlth & Med Sci, Dept Clin Med, Copenhagen, Denmark.
   [Vernal, Ditte Lammers] Aalborg Univ Hosp North, Psychiat, Aalborg, Denmark.
   [Vernal, Ditte Lammers] Aalborg Univ, Dept Clin Med, Aalborg, Denmark.
   [Mors, Ole; Knop, Filip Krag] Aarhus Univ Hosp, Psychosis Res Unit, Aarhus, Denmark.
   [Knop, Filip Krag] Univ Copenhagen, Gentofte Hosp, Ctr Clin Metab Res, Hellerup, Denmark.
   [Tolver, Anders] Steno Diabet Ctr Copenhagen, Herlev, Denmark.
   [Tolver, Anders] Univ Copenhagen, Dept Math Sci, Data Sci Lab, Copenhagen, Denmark.
   [Firth, Joseph] Univ Manchester, Manchester Acad Hlth Sci Ctr, Div Psychol & Mental Hlth, Manchester, Lancs, England.
   [Nohr, Nikolaj] Arca, Copenhagen, Denmark.
   [Skou, Soren T.] Univ Southern Denmark, Dept Sports Sci & Clin Biomech, Res Unit Musculoskeletal Funct & Physiotherapy, Odense, Denmark.
   [Skou, Soren T.] Naestved Slagelse Ringsted Hosp, Dept Physiotherapy & Occupat Therapy, Res Unit PROgrez, Slagelse, Region Zealand, Denmark.
C3 University of Copenhagen; Rigshospitalet; University of Copenhagen;
   Copenhagen University Hospital; University of Copenhagen; University of
   Copenhagen; Aalborg University; Aarhus University; University of
   Copenhagen; Herlev & Gentofte Hospital; Steno Diabetes Center;
   University of Copenhagen; University of Manchester; University of
   Southern Denmark; Naestved Hospital
RP Rafn, BS; Midtgaard, J (corresponding author), Univ Copenhagen, Mental Hlth Ctr Glostrup, Ctr Appl Res Mental Hlth Care CARMEN, Glostrup, Denmark.; Rafn, BS (corresponding author), Rigshosp, Dept Oncol, Danish Canc Soc Natl Canc Survivorship & Late Eff, Copenhagen Univ Hosp, Copenhagen, Denmark.; Midtgaard, J (corresponding author), Univ Copenhagen, Fac Hlth & Med Sci, Dept Clin Med, Copenhagen, Denmark.
EM bolette.skjoedt.rafn@regionh.dk; julie.midtgaard.klausen@regionh.dk
RI Baandrup, Lone/D-6578-2015; Firth, Joseph/JOZ-1679-2023; Nohr,
   Nikolaj/MIT-0078-2025; Knop, Filip K/B-5130-2018; Ebdrup,
   Bjørn/P-8358-2018; Rafn, Bolette/IUN-3866-2023; Vernal,
   Ditte/L-1562-2019; Skou, Soren T/I-2405-2016
OI Skou, Soren T/0000-0003-4336-7059; Midtgaard, Julie/0000-0003-2381-2127;
   Nohr, Nikolaj/0009-0001-7427-1087; Sorensen, Victor/0000-0002-0253-7544;
   Andersen, Martin Faerch/0000-0003-0469-7557
FU We thank our patient partner for invaluable input into all aspects of
   preparation of the trial including development of recruitment material,
   intervention content and setting, and outcome selection.
FX We thank our patient partner for invaluable input into all aspects of
   preparation of the trial including development of recruitment material,
   intervention content and setting, and outcome selection.
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NR 63
TC 0
Z9 1
U1 1
U2 7
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-244X
J9 BMC PSYCHIATRY
JI BMC Psychiatry
PD AUG 30
PY 2023
VL 23
IS 1
AR 634
DI 10.1186/s12888-023-05086-z
PG 13
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychiatry
GA R3MP0
UT WOS:001063429200002
PM 37648977
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Loh, C
   Meyer, JM
   Leckband, SG
AF Loh, C.
   Meyer, J. M.
   Leckband, S. G.
TI Accuracy of body image perception and preferred weight loss strategies
   in schizophrenia: a controlled pilot study
SO ACTA PSYCHIATRICA SCANDINAVICA
LA English
DT Article
DE body image; body weight; overweight; schizophrenia; size perception
ID CLINICAL ANTIPSYCHOTIC TRIALS; COMMUNITY-DWELLING PATIENTS;
   QUALITY-OF-LIFE; METABOLIC SYNDROME; MASS INDEX; ATYPICAL
   ANTIPSYCHOTICS; GAIN; INDIVIDUALS; RISPERIDONE; PREVALENCE
AB Objective: Obesity in severely mentally ill (SMI) populations is an increasing problem, but there is no controlled data regarding the relationship between SMI and weight perception.
   Method: Fifty patients with schizophrenia and 50 demographically matched control participants were recruited. Weight, height, and body image accuracy were assessed for all participants, and assessments of mood, psychotic symptom severity and anxiety, and preferred modes of weight loss were assessed for the schizophrenia sample.
   Results: Patients with schizophrenia were significantly more likely to be obese than controls (46% vs. 18%, P < 0.005), and most patients expressed an interest in losing weight. Obese participants with schizophrenia underestimated their body size (11.0%) more than controls (4.9%) (P < 0.05).
   Conclusion: Patients with schizophrenia are more likely to underestimate their body size, independent of the effects of obesity. However, they also express concern about weight issues and willingness to participate in psychoeducational groups targeted at weight loss.
C1 [Loh, C.; Meyer, J. M.; Leckband, S. G.] Univ Calif San Diego, VA San Diego Hlthcare Syst, Schizophrenia Psychosoc Rehabil Program, San Diego, CA 92161 USA.
   [Loh, C.; Meyer, J. M.] Univ Calif San Diego, Dept Psychiat, San Diego, CA 92103 USA.
C3 US Department of Veterans Affairs; Veterans Health Administration (VHA);
   VA San Diego Healthcare System; University of California System;
   University of California San Diego; University of California System;
   University of California San Diego
RP Loh, C (corresponding author), Univ Calif San Diego, VA San Diego Hlthcare Syst, Schizophrenia Psychosoc Rehabil Program, 3350 La Jolla Village Dr MC 116B, San Diego, CA 92161 USA.
EM cloh@ucsd.edu
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NR 27
TC 9
Z9 11
U1 0
U2 13
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0001-690X
EI 1600-0447
J9 ACTA PSYCHIAT SCAND
JI Acta Psychiatr. Scand.
PD FEB
PY 2008
VL 117
IS 2
BP 127
EP 132
DI 10.1111/j.1600-0447.2007.01123.x
PG 6
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 250RT
UT WOS:000252318700005
PM 18005368
DA 2025-06-11
ER

PT J
AU Abbasi-Ghahramanloo, A
   Bahadori, M
   Azad, E
   Dopeykar, N
   Mahdizadeh, P
   Azimi, AV
   Amini, H
AF Abbasi-Ghahramanloo, Abbas
   Bahadori, Mohammadkarim
   Azad, Esfandiar
   Dopeykar, Nooredin
   Mahdizadeh, Parisa
   Azimi, Amir Vahedian
   Amini, Hossein
TI Mental disorders pattern in staff of a military unit in Iran: the role
   of metabolic syndrome on latent class membership
SO BMC PSYCHIATRY
LA English
DT Article
DE Mental disorders; Comorbidity; Latent class analysis; Staff; Military
   unit
ID DSM-IV DISORDERS; HEALTH SURVEY; PSYCHIATRIC-DISORDERS;
   ADULT-POPULATION; GLOBAL BURDEN; RISK-FACTORS; PREVALENCE; COMORBIDITY;
   ANXIETY; 12-MONTH
AB Introduction Mental disorders are among the most prevalent health problems of the adult population in the world. This study aimed to identify the subgroups of staff based on mental disorders and assess the independent role of metabolic syndrome (MetS) on the membership of participants in each latent class. Methods This cross-sectional study was conducted among 694 staff of a military unit in Tehran in 2017. All staff of this military unit was invited to participate in this study. The collected data included demographic characteristics, anthropometric measures, blood pressure, biochemical parameters, and mental disorders. We performed latent class analysis using a procedure for latent class analysis (PROC LCA) in SAS to identify class membership of mental disorders using Symptom Checklist-90. Results Three latent classes were identified as healthy (92.7%), mild (4.9%), and severe (2.4%) mental disorders. Having higher age significantly decreased the odds of belonging to the mild class (adjusted OR (aOR = 0.21; 95% confidence interval (CI): 0.05-0.83) compared to the healthy class. Also, obesity decreased the odds of membership in mild class (aOR = 0.10, 95% CI: 0.01-0.92) compared to healthy class. On the other hand, being female increased the odds of being in severe class (aOR = 9.76; 95% CI: 1.35-70.65) class in comparison to healthy class. Conclusion This study revealed that 7.3% of staff fell under mild and severe classes. Considering educational workshops in the workplace about mental disorders could be effective in enhancing staff's knowledge of these disorders. Also, treatment of comorbid mental disorders may help reduce their prevalence and comorbidity.
C1 [Abbasi-Ghahramanloo, Abbas; Bahadori, Mohammadkarim; Dopeykar, Nooredin; Mahdizadeh, Parisa; Amini, Hossein] Baqiyatallah Univ Med Sci, Hlth Management Res Ctr, Tehran, Iran.
   [Abbasi-Ghahramanloo, Abbas] Ardabil Univ Med Sci, Sch Hlth, Dept Publ Hlth, Ardebil, Iran.
   [Azad, Esfandiar] Baqiyatallah Univ Med Sci, Behav Sci Res Ctr, Lifestyle Inst, Tehran, Iran.
   [Azimi, Amir Vahedian] Baqiyatallah Univ Med Sci, Nursing Fac, Trauma Res Ctr, Tehran, Iran.
C3 Baqiyatallah University of Medical Sciences (BMSU); Ardabil University
   of Medical Sciences; Baqiyatallah University of Medical Sciences (BMSU);
   Baqiyatallah University of Medical Sciences (BMSU)
RP Amini, H (corresponding author), Baqiyatallah Univ Med Sci, Hlth Management Res Ctr, Tehran, Iran.
EM hamini2005@gmail.com
RI amini, hosein/V-6467-2019; Abbasi-Ghahramanloo, Abbas/AAQ-1953-2020;
   Bahadori, Mohammadkarim/B-8056-2013; vahedian-azimi, amir/S-3795-2018
OI amini, hosein/0000-0003-0914-8768; Bahadori,
   Mohammadkarim/0000-0002-7157-9908; vahedian-azimi,
   amir/0000-0002-1678-7608
FU Baqiyatallah University of Medical Sciences
FX This research was supported by grant from Baqiyatallah University of
   Medical Sciences. This university had no role in the study design,
   analysis, interpretation of the data, writing the manuscript, or the
   decision to submit the paper for publication.
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NR 54
TC 2
Z9 2
U1 0
U2 7
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-244X
J9 BMC PSYCHIATRY
JI BMC Psychiatry
PD OCT 19
PY 2021
VL 21
IS 1
AR 513
DI 10.1186/s12888-021-03537-z
PG 8
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychiatry
GA WI6LE
UT WOS:000708468700001
PM 34663270
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Akarsu, FG
   Algin, DI
   Erdinc, OO
AF Akarsu, Fatma Ger
   Algin, Demet Ilhan
   Erdinc, Oguz Osman
TI Evaluation of comorbid diseases in obstructive sleep apnea syndrome
SO REVISTA DA ASSOCIACAO MEDICA BRASILEIRA
LA English
DT Article
DE Sleep apnea; obstructive; Cognitive dysfunction; Autonomic nervous
   system diseases
ID IMPAIRMENT; MANAGEMENT; HYPOXIA; RISK
AB OBJECTIVE: It is known that obstructive sleep apnea syndrome affects many systems due to hypoxemia and hypercarbia. We aimed to demonstrate with the utilization of well-standardized questionnaire tools and electrophysiological tests that cognitive impairment, depression, autonomic dysfunction, and metabolic syndrome may occur in association with obstructive sleep apnea syndrome.METHODS: The electrophysiological examination protocol of autonomic nervous system functions was performed with sympathetic skin response and R-R Interval. Patients were administered Epworth Sleepiness Scale, Pittsburgh Sleep Quality Index, Montreal Cognitive Assessment, and Hamilton Depression Rating Scale by physicians in face-to-face interviews.RESULTS: This study included 148 participants, consisting of 73 patients and 75 controls. There was a statistically significant difference between the patient group and control group with regard to sympathetic skin response, R-R Interval, post-hyperventilation R-R Interval, and R-R Interval variation (p<0.001). A statistically significant difference was observed between the patient group and control group in terms of median Epworth Sleepiness Scale, Pittsburgh Sleep Quality Index, and Montreal Cognitive Assessment scores. It was observed that the control group achieved significantly better scores than the patient group in delayed recall (p<0.001) and language (p<0.05) categories.CONCLUSION: Obstructive sleep apnea syndrome patients should be screened for diseases, especially in the cardiovascular system, that cause serious morbidity and impair functionality such as dementia and depression. We believe that many comorbid diseases encountered in obstructive sleep apnea syndrome patients can be prevented with early diagnosis and continuous positive airway pressure treatment.KEYWORDS: Sleep apnea, obstructive. Cognitive dysfunction. Autonomic nervous system diseases.
C1 [Akarsu, Fatma Ger; Algin, Demet Ilhan; Erdinc, Oguz Osman] Eskisehir Osmangazi Univ, Dept Neurol Eskisehir, Eskisehir, Turkiye.
C3 Eskisehir Osmangazi University
RP Akarsu, FG (corresponding author), Eskisehir Osmangazi Univ, Dept Neurol Eskisehir, Eskisehir, Turkiye.
EM fatma.ger@hotmail.com
RI Ger Akarsu, Fatma/GQQ-2054-2022; İLHAN ALGIN, Demet/JWA-2099-2024
OI GER AKARSU, FATMA/0000-0003-3171-4535; ILHAN ALGIN,
   DEMET/0000-0002-3322-5105
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NR 25
TC 1
Z9 1
U1 0
U2 7
PU ASSOC MEDICA BRASILEIRA
PI SAO PAULO
PA RUA SAO CARLOS DO PINHAL 324, CAIXA POSTAL 8904, SAO PAULO, SP, BRAZIL
SN 0104-4230
EI 1806-9282
J9 REV ASSOC MED BRAS
JI Rev. Assoc. Med. Bras.
PY 2023
VL 69
IS 3
BP 421
EP 425
DI 10.1590/1806-9282.20221082
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA A3FF2
UT WOS:000954017300001
PM 36820771
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Kishi, T
   Iwata, N
AF Kishi, T.
   Iwata, N.
TI Efficacy and Tolerability of Histamine-2 Receptor Antagonist Adjunction
   of Antipsychotic Treatment in Schizophrenia: A Meta-analysis of
   Randomized Placebo-controlled Trials
SO PHARMACOPSYCHIATRY
LA English
DT Article
DE histamine-2 receptor antagonists; schizophrenia; weight gain;
   psychopathology; leptin; systematic review; meta-analysis
ID INDUCED WEIGHT-GAIN; DOUBLE-BLIND; CARDIOMETABOLIC RISK; CLINICAL-TRIAL;
   OLANZAPINE; NIZATIDINE
AB Introduction: No comprehensive meta-analysis has been performed concerning the efficacy and tolerability of adjunctive therapy with histamine-2 receptor antagonists (H2R-ANTs) in schizophrenia patients who were treated with antipsychotics.
   Methods: Risk ratios, standardized mean differences (SMD), and 95% confidence intervals were calculated.
   Results: We included 8 double-blinded, randomized placebo-controlled trials (RCTs) (n=418) that met the inclusion criteria (famotidine: N=3, n=74; nizatidine: N=4, n=292; ranitidine: N=1, n=52). Pooled H2R-ANTs were not different from placebo with regard to reduction in overall symptoms and body weight. However, pooled H2R-ANTs resulted in lower body mass index (BMI) than placebo (SMD=-0.68). Moreover, nizatidine was associated with an increase in plasma leptin levels (SMD=-1.14). There were no significant differences in the discontinuation rates due to all-cause, side effects, and inefficacy between pooled H2R-ANTs and placebo. However, nizatidine produced more depression and dry mouth than placebo.
   Discussion: H2R-ANT adjunctive therapy did not improve overall symptoms. To clarify the opposite results between body weight and BMI, future research should investigate long-term efficacy and generate more safety data by using larger samples.
C1 [Kishi, T.; Iwata, N.] Fujita Hlth Univ, Sch Med, Dept Psychiat, Toyoake, Aichi 4701192, Japan.
C3 Fujita Health University
RP Kishi, T (corresponding author), Fujita Hlth Univ, Sch Med, Dept Psychiat, Toyoake, Aichi 4701192, Japan.
EM tarok@fujita-hu.ac.jp
OI IWATA, Nakao/0000-0003-3189-6076
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NR 25
TC 14
Z9 14
U1 0
U2 5
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0176-3679
EI 1439-0795
J9 PHARMACOPSYCHIATRY
JI Pharmacopsychiatry
PD JAN
PY 2015
VL 48
IS 1
BP 30
EP 36
DI 10.1055/s-0034-1390478
PG 7
WC Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Psychiatry
GA AY7CJ
UT WOS:000347718700007
PM 25321187
DA 2025-06-11
ER

PT J
AU Jeremiah, OJ
   Cousins, G
   Leacy, FP
   Kirby, BP
   Ryan, BK
AF Jeremiah, Olaitan J.
   Cousins, Grainne
   Leacy, Finbarr P.
   Kirby, Brian P.
   Ryan, Benedict K.
TI Evaluation of the effect of insulin sensitivity-enhancing lifestyle- and
   dietary-related adjuncts on antidepressant treatment response: protocol
   for a systematic review and meta-analysis
SO SYSTEMATIC REVIEWS
LA English
DT Review
DE Depression; Adjuncts; Insulin sensitivity; Lifestyle; Vitamin D; Zinc;
   Magnesium; Unsaturated fatty acids; Probiotics; Systematic review
ID VITAMIN-D SUPPLEMENTATION; TYPE-2 DIABETES-MELLITUS; MAJOR DEPRESSIVE
   DISORDER; MEDITERRANEAN DIET; GLYCEMIC CONTROL; DOUBLE-BLIND; PROBIOTIC
   SUPPLEMENTATION; MAGNESIUM SUPPLEMENTATION; ZINC SUPPLEMENTATION;
   METABOLIC SYNDROME
AB Background: Depression is the leading cause of disability worldwide and is known to be associated with insulin resistance (IR). Insulin resistance worsens the symptoms of depression and reduces the effectiveness of antidepressant medications in some depressed patients. Many studies have assessed the effect of adjunctive exercise, vitamin D supplementation, zinc supplementation, magnesium, probiotics, unsaturated fatty acids, and hygienic-dietary recommendations (sleep hygiene, healthy diet, physical activity, and sunlight exposure, combined or singly used), individually, on antidepressant treatment response. However, despite the reported insulin sensitivity-enhancing potential of these adjuncts, no systematic review has collectively analysed their antidepressant effect with regards to insulin sensitivity.
   Methods/design: In this systematic review, we will analyse the effect of the above-stated adjuncts on antidepressant treatment response (primary outcome) in comparison with treatment as usual with or without adjunctive placebo after identifying the relevant trials from a systematic literature search. Randomised controlled trials involving clinically depressed patients with diagnosis of major depressive, dysthymic or bipolar disorder will be considered. Changes in insulin sensitivity parameters, following treatment, will also be analysed as the secondary outcome. Effect estimates of the included trials will be combined using random-effects meta-analysis, while addressing risk of bias issues. Any significant heterogeneity between studies will be explored using sensitivity and subgroup analyses.
   Discussion: The findings of this review will contribute to the evidence base regarding the utility of non-pharmacological insulin-sensitising treatments in enhancing conventional antidepressant treatment response.
C1 [Jeremiah, Olaitan J.; Cousins, Grainne; Kirby, Brian P.; Ryan, Benedict K.] RCSI, Sch Pharm, 123,St Stephens Green, Dublin 2, Ireland.
   [Leacy, Finbarr P.] RCSI, Data Sci Ctr, 123,St Stephens Green, Dublin 2, Ireland.
C3 Royal College of Surgeons - Ireland; Royal College of Surgeons - Ireland
RP Ryan, BK (corresponding author), RCSI, Sch Pharm, 123,St Stephens Green, Dublin 2, Ireland.
EM benedictryan@rcsi.ie
RI Kirby, Brian/D-5771-2012; Cousins, Grainne/C-4807-2015; Leacy, Finbarr
   Patrick/F-2755-2016
OI Cousins, Grainne/0000-0003-2985-7668; Jeremiah, Olaitan
   Jibola/0000-0001-6698-5664; Ryan, Benedict/0000-0003-0165-3639; Leacy,
   Finbarr Patrick/0000-0001-5561-485X; Kirby, Brian/0000-0001-9056-830X
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NR 95
TC 7
Z9 7
U1 1
U2 15
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 2046-4053
J9 SYST REV-LONDON
JI Syst. Rev.
PD FEB 25
PY 2019
VL 8
AR 62
DI 10.1186/s13643-019-0978-8
PG 11
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA HM9UH
UT WOS:000459830000003
PM 30803432
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Fernández-Torres, RM
   Pita-Fernández, S
   Fonseca, E
AF Maria Fernandez-Torres, Rosa
   Pita-Fernandez, Salvador
   Fonseca, Eduardo
TI Quality of life and related factors in a cohort of plaque-type psoriasis
   patients in La Coruna, Spain
SO INTERNATIONAL JOURNAL OF DERMATOLOGY
LA English
DT Article
DE psoriasis; psoriasis treatment; quality of life
ID IMPACT; MODERATE; DEPRESSION; MORBIDITY; SEVERITY; ANXIETY; DLQI
AB BackgroundPsoriasis can significantly affect the physical, psychological, and social aspects of a patient's life. Many studies have evaluated the effects of psoriasis on quality of life (QoL), but results in many cases are contradictory.
   ObjectivesThis study was conducted to assess the relationships between the characteristics of psoriasis (cutaneous severity, arthropathy, treatment) and comorbidities with QoL and to determine which factors have a major influence.
   MethodsWe assessed demographic data, the severity of cutaneous involvement, psoriasis treatment, presence of arthropathy, psoriasis duration, smoking status, alcohol intake, and the presence of comorbidities. Concomitant diseases were evaluated using the Charlson Comorbidity Index and the National Cholesterol Education Program Adult Treatment Panel III (ATP-III) criteria for metabolic syndrome. Quality of life was assessed using the Dermatology Life Quality Index (DLQI).
   ResultsMultivariate analysis showed that factors associated with QoL impairment included gender (women experienced greater impact: odds ratio [OR] 2.85, 95% confidence interval [CI] 1.48-5.49; P=0.002); psoriasis duration (patients with longer durations of psoriasis and psoriasis treatment experienced less impairment: OR 0.96, 95% CI 0.94-0.99; P=0.004); and treatment type (impact was lower in patients receiving biologic drugs than in those using topical treatment [OR 3.15, 95% CI 1.50-6.62; P=0.002] and in those using biologics compared with those using conventional systemic treatment [OR 2.23, 95% CI 0.98-5.05; P=0.053]). Psoriasis severity measured according to scores on the Psoriasis Area and Severity Index (PASI) and body surface area affected was not related to QoL impairment. Comorbidities were associated with impaired QoL in the univariate analysis but not after adjusting for other covariates.
   ConclusionsFactors associated with greater impairment of QoL were gender, psoriasis duration, and type of treatment. Patients receiving systemic and biologic therapies reported better QoL.
C1 [Maria Fernandez-Torres, Rosa; Fonseca, Eduardo] Univ Hosp La Coruna, Dept Dermatol, La Coruna 15006, Spain.
   [Pita-Fernandez, Salvador] Univ Hosp La Coruna, Dept Clin Epidemiol & Biostat, La Coruna 15006, Spain.
C3 Complejo Hospitalario Universitario A Coruna; Complejo Hospitalario
   Universitario A Coruna
RP Fernández-Torres, RM (corresponding author), Univ Hosp La Coruna, Dept Dermatol, Xubias Arriba 84, La Coruna 15006, Spain.
EM rosaftorres@gmail.com
RI Fonseca, Eduardo/D-9725-2011
OI Fonseca, Eduardo/0000-0002-8048-2681
FU Pfizer, Inc.
FX This study was supported in part by an investigator-initiated research
   grant from Pfizer, Inc.
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NR 25
TC 25
Z9 25
U1 0
U2 8
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0011-9059
EI 1365-4632
J9 INT J DERMATOL
JI Int. J. Dermatol.
PD NOV
PY 2014
VL 53
IS 11
BP E507
EP E511
DI 10.1111/ijd.12294
PG 5
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA AS3KX
UT WOS:000344177600005
PM 25266080
DA 2025-06-11
ER

PT J
AU Marasca, C
   Fabbrocini, G
   Barrea, L
   Capasso, G
   Di Guida, A
   Cinelli, E
   Fontanella, G
AF Marasca, Claudio
   Fabbrocini, Gabriella
   Barrea, Luigi
   Capasso, Gianmarco
   Di Guida, Adriana
   Cinelli, Eleonora
   Fontanella, Giuseppina
TI Endocrinological disorders and inflammatory skin diseases during
   COVID-19 outbreak: a review of the literature
SO MINERVA ENDOCRINOLOGICA
LA English
DT Review
DE COVID-19; Skin; Endocrinology
ID POLYCYSTIC-OVARY-SYNDROME; BODY-MASS INDEX; VITAMIN-D; METABOLIC
   SYNDROME; PSORIASIS; PREVALENCE; ACNE
AB INTRODUCTION: In the next future, dermatologists, endocrinologist and physicians may cope with the impact of extent SARS-CoV-2 (COVID-19) infection over chronic inflammatory skin diseases and their treatment. COVID-19 pandemic obliged many countries to impose social restrictions, resulting in the need to adapt daily lifestyle habits and working activities. These changes have drastically reduced physical activity and social interactions, with the possible increase of anxiety, eating disorders and weight gain.
   EVIDENCE ACQUISITION: We searched for relevant studies (trials, real-life studies and case reports, meta-analysis, pooled data analysis, reviews) on endocrine disorders and inflammatory skin diseases. The database used was PubMed. The studies included were those published in the English language between January 1, 2018 and May 5.2020.
   EVIDENCE SYNTHESIS: Several studies have been previously showed the association of overweight and obesity, with the metabolic syndrome and insulin-resistance. It has been demonstrated how these conditions correlate with the worsening of such chronic inflammatory skin diseases, such as psoriasis, hidradenitis suppurativa and acne. Many evidences suggest an important role of adipose tissue in the production of pro-inflammatory cytokines (Leptin, adiponectin, TNF alpha, IL-6, MCP-1, PAI-1), involved in the pathogenesis and the exacerbations of these skin diseases. In addition, we should expect an increasing incidence rate of hypovitaminosis Din the next future due to reduced sun exposure caused by isolation at home and missed holidays. Scientific evidences already show the important immunomodulating role of vitamin D in inflammatory skin diseases.
   CONCLUSIONS: Our study pays attention on medium-long term effects of COVID-19 outbreak on inflammatory skin disorders, due to the lifestyle changes. In such context this review considers how a multidisciplinary approach, involving dermatologists, nutritionists and endocrinologists, may lead to a better management of dermatologic patients.
C1 [Marasca, Claudio; Fabbrocini, Gabriella; Capasso, Gianmarco; Di Guida, Adriana; Cinelli, Eleonora; Fontanella, Giuseppina] Federico II Univ Hosp, Dept Clin Med & Surg, Sect Dermatol, Via Pansini 5, I-80131 Naples, Italy.
   [Barrea, Luigi] Federico II Univ Hosp, Dept Clin Med & Surg, Sect Endocrinol, Naples, Italy.
C3 University of Naples Federico II; University of Naples Federico II
RP Capasso, G (corresponding author), Federico II Univ Hosp, Dept Clin Med & Surg, Sect Dermatol, Via Pansini 5, I-80131 Naples, Italy.
EM gianm.capasso@gmail.com
RI Marasca, Claudio/AFT-0737-2022; Barrea, Luigi/K-6551-2016
OI Barrea, Luigi/0000-0001-9054-456X; Capasso,
   Gianmarco/0000-0002-0076-4575; Fabbrocini, Gabriella/0000-0002-0064-1874
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NR 66
TC 10
Z9 10
U1 0
U2 8
PU EDIZIONI MINERVA MEDICA
PI TURIN
PA CORSO BRAMANTE 83-85 INT JOURNALS DEPT., 10126 TURIN, ITALY
SN 0391-1977
EI 1827-1634
J9 MINERVA ENDOCRINOL
JI Minerva Endocrinol.
PD DEC
PY 2020
VL 45
IS 4
BP 345
EP 353
DI 10.23736/S0391-1977.20.03248-4
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA PY8LO
UT WOS:000612292900006
PM 32969629
DA 2025-06-11
ER

PT J
AU Annamalai, A
   Kosir, U
   Tek, C
AF Annamalai, Aniyizhai
   Kosir, Urska
   Tek, Cenk
TI Prevalence of obesity and diabetes in patients with schizophrenia
SO WORLD JOURNAL OF DIABETES
LA English
DT Article
DE Schizophrenia; Antipsychotic; Diabetes; Body mass index; Obesity
ID METABOLIC SYNDROME
AB AIM
   To compare the prevalence of diabetes in patients with schizophrenia treated at a community mental health center with controls in the same metropolitan area and to examine the effect of antipsychotic exposure on diabetes prevalence in schizophrenia patients.
   METHODS
   The study was a comprehensive chart review of psychiatric notes of patients with schizophrenia and schizoaffective disorder treated at a psychosis program in a community mental health center. Data collected included psychiatric diagnoses, diabetes mellitus diagnosis, medications, allergies, primary care status, height, weight, body mass index (BMI), substance use and mental status exam. Local population data was downloaded from the Centers for Disease Control Behavioral Risk Factor Surveillance System. Statistical methods used were. 2 test, Student's t test, general linear model procedure and binary logistic regression analysis.
   RESULTS
   The study sample included 326 patients with schizophrenia and 1899 subjects in the population control group. Demographic data showed control group was on average 7.6 years older (P = 0.000), more Caucasians (78.7% vs 38.3%, P = 0.000), and lower percentage of males (40.7% vs 58.3%, P = 0.000). Patients with schizophrenia had a higher average BMI than the subjects in the population control (32.11, SD = 7.72 vs 27.62, SD = 5.93, P = 0.000).Patients with schizophrenia had a significantly higher percentage of obesity (58.5% vs 27%, P = 0.000) than the population group. The patients with schizophrenia also had a much higher rate of diabetes compared to population control (23.9% vs 12.2%, P = 0.000). After controlling for age sex, and race, having schizophrenia was still associated with increased risk for both obesity (OR = 3.25, P = 0.000) and diabetes (OR = 2.42, P = 0.000). The increased risk for diabetes remained even after controlling for obesity (OR = 1.82, P = 0.001). There was no difference in the distribution of antipsychotic dosage, second generation antipsychotic use or multiple antipsychotic use within different BMI categories or with diabetes status in the schizophrenia group.
   CONCLUSION
   This study demonstrates the high prevalence of obesity and diabetes in schizophrenia patients and indicates that antipsychotics may not be the only contributor to this risk.
C1 [Annamalai, Aniyizhai; Kosir, Urska; Tek, Cenk] Yale Sch Med, Dept Psychiat, 333 Cedar St, New Haven, CT 06519 USA.
C3 Yale University
RP Annamalai, A (corresponding author), Yale Sch Med, Dept Psychiat, 333 Cedar St, New Haven, CT 06519 USA.
EM aniyizhai.annamalai@yale.edu
RI Tek, Cenk/M-1552-2019
FU National Institute of Diabetes and Digestive and Kidney Diseases
   [R01DK093924]
FX Supported by National Institute of Diabetes and Digestive and Kidney
   Diseases, No. R01DK093924.
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NR 16
TC 117
Z9 123
U1 0
U2 16
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 7041 Koll Center Parkway, Suite 160, PLEASANTON, CA, UNITED STATES
EI 1948-9358
J9 WORLD J DIABETES
JI World J. Diabetes
PD AUG 15
PY 2017
VL 8
IS 8
BP 390
EP 396
DI 10.4239/wjd.v8.i8.390
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA FE1BZ
UT WOS:000407954700001
PM 28861176
OA gold, Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Gugliucci, A
AF Gugliucci, Alejandro
TI Fructose surges damage hepatic adenosyl-monophosphate-dependent kinase
   and lead to increased lipogenesis and hepatic insulin resistance
SO MEDICAL HYPOTHESES
LA English
DT Article
DE Methylglyoxal; AMPK; Obesity; Metabolic syndrome; Fructose; Sugar;
   Hyperinsulinemia; Hyperlipidemia; Diabetes
ID FATTY LIVER-DISEASE; DE-NOVO LIPOGENESIS; OXIDATIVE STRESS;
   CARDIOVASCULAR-DISEASE; DIABETIC-NEPHROPATHY; METABOLIC SYNDROME;
   URIC-ACID; AMPK; OBESITY; ENERGY
AB Fructose may be a key contributor to the biochemical alterations which promote the metabolic syndrome (MetS), non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes (T2DM): (a) its consumption in all forms but especially in liquid form has much increased alongside with incidence of MetS conditions; (b) it is metabolized almost exclusively in the liver, where it stimulates de novo lipogenesis to drive hepatic triglyceride (TG) synthesis which (c) contributes to hepatic insulin resistance and NAFLD (Lustig et al., 2015; Weiss et al., 2013; Lim et al., 2010; Schwarzet al., 2015; Stanhope et al., 2009, 2013) [1-6]. The specifics of fructose metabolism and its main location in the liver serve to explain many of the possible mechanisms involved. It also opens questions, as the consequences of large increases in fructose flux to the liver may wreak havoc with the regulation of metabolism and would produce two opposite effects (inhibition and activation of AMP dependent kinase-AMPK) that would tend to cancel each other. We posit that (1) surges of fructose in the portal vein lead to increased unregulated flux to trioses accompanied by unavoidable methylglyoxal (MG) production, (2) the new, sudden flux exerts carbonyl stress on the three arginines on the gamma subunits AMP binding site of AMPK, irreversible blocking some of the enzyme molecules to allosteric modulation, (3) this explains why, even when fructose quick phosphorylation increases AMP and should therefore activate AMPK, the effects of fructose are compatible with inactivation of AMPK, which then solves the apparent metabolic paradox. We put forward the hypothesis that fructose loads, via the increase in MG flux worsens the fructose-driven metabolic disturbances that lead to unrestricted de novo lipogenesis, fatty liver and hepatic insulin resistance. It does so via the silencing of AMPK. Our hypothesis is testable and if proven correct will shed some further light on fructose metabolism in the liver. It will also open new roads in glycation research, as modulation of MG catabolism may be a way to dampen the damage. Research on this area may have important therapeutic potential, e.g., more momentum to find new and improved carbonyl quenchers, new insights on the action of metformin, more evidence for the role of GAPDH inactivation due to mitochondrial overload in diabetes complications. AMPK plays a central role in metabolism, and its function varies in different tissues. For that reason, synthetic activators will always stumble with unwanted or unpredictable effects. Preventing MG damage on the protein could be a safer therapeutic avenue. (C) 2016 Elsevier Ltd. All rights reserved.
C1 [Gugliucci, Alejandro] Touro Univ Calif, Coll Osteopath Med, Dept Res, Vallejo, CA USA.
C3 Touro University California
RP Gugliucci, A (corresponding author), Touro Univ Calif, 1310 Club Dr, Vallejo, CA 94592 USA.
EM alejandro.gugliucci@tu.edu
FU Touro University-California, Vallejo, CA, USA
FX This work was supported by Touro University-California, Vallejo, CA,
   USA. The author is grateful to Pamela Chu for critical reading of the
   manuscript.
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NR 42
TC 26
Z9 30
U1 0
U2 24
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0306-9877
EI 1532-2777
J9 MED HYPOTHESES
JI Med. Hypotheses
PD AUG
PY 2016
VL 93
BP 87
EP 92
DI 10.1016/j.mehy.2016.05.026
PG 6
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA DR7KG
UT WOS:000380077900018
PM 27372863
DA 2025-06-11
ER

PT J
AU Vgontzas, AN
   Bixier, EO
   Chrousos, GP
AF Vgontzas, AN
   Bixier, EO
   Chrousos, GP
TI Sleep apnea is a manifestation of the metabolic syndrome
SO SLEEP MEDICINE REVIEWS
LA English
DT Review
DE sleep apnea; visceral obesity; insulin resistance; interleukin-6; tumor
   necrosis factor-alpha; daytime sleepiness
ID NECROSIS-FACTOR-ALPHA; EXCESSIVE DAYTIME SLEEPINESS; SUBCUTANEOUS
   ADIPOSE-TISSUE; POLYCYSTIC-OVARY-SYNDROME; INSULIN-RESISTANCE;
   RISK-FACTOR; SERUM LEPTIN; RESPIRATORY DEPRESSION; VISCERAL OBESITY;
   ELEVATED LEVELS
AB Obstructive steep apnea (OSA) is a prevalent disorder particularly among middle-aged, obese men, although its existence in women as well as in lean individuals is increasingly recognized. Despite the early recognition of the strong association between OSA and obesity, and OSA and cardiovascular problems, steep apnea has been treated as a 'local abnormality' of the respiratory track rather than as a 'systemic illness.' In 1997, we first reported that the pro-inflammatory cytokines interteukin-6 (IL-6) and tumor necrosis factor-alpha (TNF alpha) were elevated in patients with disorders of excessive daytime sleepiness (EDS) and proposed that these cytokines were mediators of daytime sleepiness. Also, we reported a positive correlation between IL-6 or TNFa plasma levels and the body-mass-index (BMI). In subsequent studies, we showed that IL-6, TNFa, and insulin levels were elevated in steep apnea independently of obesity and that visceral fat, was the primary parameter linked with steep apnea. Furthermore, our findings that women with the polycystic ovary syndrome (PCOS) (a condition associated with hyperandrogenism and insulin resistance) were much more likely than controls to have steep disordered breathing (SDB) and daytime sleepiness, suggests a pathogenetic role of insulin resistance in OSA. Other findings that support the view that steep apnea and sleepiness in obese patients may be manifestations of the Metabolic Syndrome, include: obesity without steep apnea is associated with daytime sleepiness; PCOS and diabetes type 2 are independently associated with EDS after controlling for SDB, obesity, and age; increased prevalence of steep apnea in post-menopausal women, with hormonal replacement therapy associated with a significantly reduced risk for OSA; lack of effect of continuous positive airway pressure (CPAP) in obese patients with apnea on hypercytokinemia and insulin resistance indices; and that the prevalence of the metabolic syndrome in the US population from the Third National Health and Nutrition Examination Survey (1988-1994) parallels the prevalence of symptomatic steep apnea in general random samples. Finally, the beneficial effect of a cytokine antagonist on EDS in obese, mate apneics and that of exercise on SDB in a general random sample, supports the hypothesis that cytokines and insulin resistance are mediators of EDS and steep apnea in humans.
C1 Penn State Univ, Milton S Hershey Med Ctr, Coll Med, Dept Psychiat H073, Hershey, PA 17033 USA.
   NIH, Pediat & Reprod Endocrinol Branch, Bethesda, MD 20892 USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE);
   Pennsylvania State University; Penn State Health; National Institutes of
   Health (NIH) - USA
RP Penn State Univ, Milton S Hershey Med Ctr, Coll Med, Dept Psychiat H073, 500 Univ Dr, Hershey, PA 17033 USA.
EM axv3@psu.edu
FU NHLBI NIH HHS [HL40916, HL51931, HL64415] Funding Source: Medline
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NR 93
TC 400
Z9 463
U1 0
U2 53
PU W B SAUNDERS CO LTD
PI LONDON
PA 32 JAMESTOWN RD, LONDON NW1 7BY, ENGLAND
SN 1087-0792
EI 1532-2955
J9 SLEEP MED REV
JI Sleep Med. Rev.
PD JUN
PY 2005
VL 9
IS 3
BP 211
EP 224
DI 10.1016/j.smrv.2005.01.006
PG 14
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 932OY
UT WOS:000229564300006
PM 15893251
DA 2025-06-11
ER

PT J
AU Cabrera, DM
   Diaz, MM
   Grimshaw, A
   Salvatierra, J
   Garcia, PJ
   Hsieh, E
AF Cabrera, Diego M.
   Diaz, Monica M.
   Grimshaw, Alyssa
   Salvatierra, Justina
   Garcia, Patricia J.
   Hsieh, Evelyn
TI Aging with HIV in Latin America and the Caribbean: a Systematic Review
SO CURRENT HIV/AIDS REPORTS
LA English
DT Review
DE HIV; Aging; Latin America; The Caribbean; Morbidity
ID RIO-DE-JANEIRO; MINI-MENTAL-STATE; ANTIRETROVIRAL THERAPY; INFECTED
   PATIENTS; NEUROCOGNITIVE DISORDERS; METABOLIC SYNDROME; NONCOMMUNICABLE
   DISEASES; RISK-FACTORS; PREVALENCE; HIV/AIDS
AB Purpose of Review With the establishment of antiretroviral treatment (ART) programs in low- and middle-income countries, people with HIV (PWH) in Latin America and the Caribbean (LAC) are living longer, subsequently developing chronic non-communicable diseases (NCDs). Few studies focus on the impact of aging among older LAC PWH. This systematic review aims to fill this information gap and understand the burden of aging with HIV in LAC. We identified peer-reviewed literature published in English, Spanish, or Portuguese from several databases to assess currently available evidence on the burden of aging with HIV in LAC and selected six common NCDs found in older PWH (cardiovascular disease [CVD], bone and musculoskeletal [MSK] disorders, cancer, renal disease, neurocognitive impairment [NCI], and depression). Recent Findings Of the 5942 publications reviewed, only 53 articles were found with populations 40 years and older or age-related findings (27 CVD, 13 NCI or depression, 6 MSK disorders, 4 renal disease, 3 cancer). Most (79%) publications were from Brazil with few longitudinal studies on aging with HIV. Prevalence of illnesses such as CVD, NCI, depression, or osteoporosis varied widely depending on the screening instrument utilized and geographic population surveyed. Age was a significant predictor of comorbidity in nearly all studies. Our results demonstrate the need for longitudinal studies and validated screening instruments appropriate for use among PWH in LAC. Understanding the mechanisms behind aging in HIV and the roles of sociocultural factors and genetic diversity specific to LAC is needed to appropriately manage chronic comorbidities as PWH age.
C1 [Cabrera, Diego M.] Yale Sch Publ Hlth, Dept Epidemiol Microbial Dis, New Haven, CT USA.
   [Cabrera, Diego M.; Diaz, Monica M.; Garcia, Patricia J.] Univ Peruana Cayetano Heredia, Sch Publ Hlth & Adm, Epidemiol STD&HIV Unit, Lima, Peru.
   [Diaz, Monica M.] Univ N Carolina, Dept Neurol, Chapel Hill, NC 27515 USA.
   [Grimshaw, Alyssa] Yale Univ, Harvey Cushing John Hay Whitney Med Lib, New Haven, CT USA.
   [Salvatierra, Justina] Univ Peruana Cayetano Heredia, Med Lib, Lima, Peru.
   [Hsieh, Evelyn] Yale Sch Med, Sect Rheumatol Allergy & Immunol, 300 Cedar St TAC S-525,POB 208031, New Haven, CT 06520 USA.
C3 Yale University; Universidad Peruana Cayetano Heredia; University of
   North Carolina; University of North Carolina Chapel Hill; Yale
   University; Universidad Peruana Cayetano Heredia; Yale University
RP Hsieh, E (corresponding author), Yale Sch Med, Sect Rheumatol Allergy & Immunol, 300 Cedar St TAC S-525,POB 208031, New Haven, CT 06520 USA.
EM evelyn.hsieh@yale.edu
RI Grimshaw, Alyssa/AAD-8669-2020; GARCIA, PAULA/H-3149-2018
OI Garcia, Patricia J./0000-0003-3874-2256; Diaz,
   Monica/0000-0001-9663-5948
FU Fogarty International Center (FIC) at the National Institutes of Health
   (NIH); National Institute of Arthritis and Musculoskeletal and Skin
   Diseases (NIAMS) [D43TW010540]; FIC at the NIH [D43TW009343];
   NIH/Fogarty International Center [K01TW009995]; Rheumatology Research
   Foundation K Supplement Award; John E. Fogarty International Center for
   Advanced Study in the Health Sciences; National Institute of Mental
   Health [D43TW009343] Funding Source: NIH RePORTER; National Heart Lung
   and Blood Institute; National Institute of Neurological Disorders and
   Stroke; John E. Fogarty International Center for Advanced Study in the
   Health Sciences [D43TW010540] Funding Source: NIH RePORTER
FX Dr. Diego M. Cabrera serves as a Fogarty Global Health Trainee and is
   supported by the Fogarty International Center (FIC) at the National
   Institutes of Health (NIH) and the National Institute of Arthritis and
   Musculoskeletal and Skin Diseases (NIAMS) under grant number
   D43TW010540. Dr. Monica M. Diaz serves as a Fogarty Global Health
   Trainee and is supported by the FIC at the NIH under grant number
   D43TW009343. Dr. Hsieh is supported by NIH/Fogarty International Center
   K01TW009995 and the Rheumatology Research Foundation K Supplement Award.
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NR 99
TC 16
Z9 17
U1 0
U2 6
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1548-3568
EI 1548-3576
J9 CURR HIV-AIDS REP
JI Curr. Hiv/Aids Rep.
PD FEB
PY 2021
VL 18
IS 1
BP 1
EP 47
DI 10.1007/s11904-020-00538-7
EA JAN 2021
PG 47
WC Infectious Diseases
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Infectious Diseases
GA PY3VX
UT WOS:000605105800001
PM 33400168
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Sinnathurai, P
   Buchbinder, R
   Hill, C
   Lassere, M
   March, L
AF Sinnathurai, Premarani
   Buchbinder, Rachelle
   Hill, Catherine
   Lassere, Marissa
   March, Lyn
TI Comorbidity in psoriatic arthritis and rheumatoid arthritis
SO INTERNAL MEDICINE JOURNAL
LA English
DT Article
DE arthritis; psoriatic; arthritis; rheumatoid; cardiovascular diseases;
   comorbidity; registries
ID CARDIOVASCULAR RISK-FACTORS; METABOLIC SYNDROME; INCREASED PREVALENCE;
   CLINICAL-TRIALS; SELF-REPORT; OBESITY; MORBIDITY; AUSTRALIA; MORTALITY;
   DISEASES
AB Background: Comorbid conditions are common and impact outcomes in people with rheumatoid arthritis (RA), but less data are available for psoriatic arthritis (PsA).
   Aims: To describe baseline demographics and prevalence of comorbidities in participants with PsA in an Australian cohort using data from the Australian Rheumatology Association Database (ARAD) and to compare the prevalence of comorbidities in ARAD participants with PsA with those with RA.
   Methods: ARAD is a voluntary national registry for inflammatory arthritis. Data, including demographic details, medication use, history of comorbid medical illnesses and patient-reported outcomes, all self-reported, were extracted from questionnaires completed at the time of database enrolment for participants with PsA and RA. Demographic information and prevalence of comorbidities were summarised using descriptive statistics. Prevalence of comorbidities in PsA and RA were compared using logistic regression, adjusting for age, gender, disease duration, education, employment and prednisone use.
   Results: There were 490 participants with PsA, 59.2% female, mean (standard deviation (SD)) age 50.4 (21.1) years and disease duration 16.4 (9.7) years, and 57.8% reported having two or more comorbidities. Hypertension (38.2%) and depression (35.9%) were the most common. Compared with RA, participants with PsA had greater odds of depression (adjusted OR (95% CI): 2.1 (1.7-2.6)), hypertension (1.7 (1.4-2.1)), hyperlipidaemia (2.0 (1.6-2.5)), diabetes (2.2 (1.6-3.0)) and a history of ischaemic heart disease (2.0 (1.3-2.9)).
   Conclusions: High rates of comorbidity were found in ARAD participants with PsA. The prevalence of depression, cardiovascular risk factors and other comorbidities were higher in PsA than RA participants in our Australian cohort.
C1 [Sinnathurai, Premarani; March, Lyn] Northern Sydney Local Hlth Dist, Inst Bone & Joint Res, Kolling Inst, Sydney, NSW, Australia.
   [Lassere, Marissa] St George Hosp, Dept Rheumatol, Sydney, NSW, Australia.
   [Sinnathurai, Premarani; March, Lyn] Royal North Shore Hosp, Dept Rheumatol, Reserve Rd, St Leonards, NSW 2065, Australia.
   [Sinnathurai, Premarani; March, Lyn] Univ Sydney, Sydney Med Sch, Sydney, NSW, Australia.
   [Lassere, Marissa] Univ New South Wales, Sch Publ Hlth & Community Med, Sydney, NSW, Australia.
   [Buchbinder, Rachelle] Cabrini Inst, Monash Dept Clin Epidemiol, Melbourne, Vic, Australia.
   [Buchbinder, Rachelle] Monash Univ, Dept Epidemiol & Prevent Med, Sch Publ Hlth & Prevent Med, Melbourne, Vic, Australia.
   [Hill, Catherine] Queen Elizabeth Hosp, Adelaide, SA, Australia.
   [Hill, Catherine] Univ Adelaide, Adelaide, SA, Australia.
C3 Northern Sydney Local Health District; University of Sydney; Kolling
   Institute of Medical Research; St George Hospital; Royal North Shore
   Hospital; University of Sydney; University of New South Wales Sydney;
   Cabrini Health; Monash University; Monash University; University of
   Adelaide
RP Sinnathurai, P (corresponding author), Royal North Shore Hosp, Dept Rheumatol, Reserve Rd, St Leonards, NSW 2065, Australia.
EM premarani.sinnathurai@health.nsw.gov.au
RI March, Lyn/IZP-5723-2023; Hill, Catherine/AAE-7152-2019; Buchbinder,
   Rachelle/G-2952-2011; Sinnathurai, Premarani/E-6558-2015
OI Sinnathurai, Premarani/0000-0002-8142-1274; March,
   Lyn/0000-0003-1736-8111; Buchbinder, Rachelle/0000-0002-0597-0933
FU Australian National Health and Medical Research Council (NHMRC) Enabling
   Grant; Amgen Australia Pty Ltd; Aventis; AstraZeneca; Roche; Monash
   University; Cabrini Health; NHMRC; Arthritis South Australia; NHMRC
   Senior Principal Research Fellowship; SA LSS Support Group Grant;
   Arthritis Australia; Australian Rheumatology Association from AbbVie Pty
   Ltd; Pfizer Australia; Sanofi Australia; Celgene Australian NZ;
   Bristol-Myers Squibb Australia Pty Ltd.
FX The Australian Rheumatology Association Database (ARAD) is currently
   supported by unrestricted educational grants administered through the
   Australian Rheumatology Association from AbbVie Pty Ltd, Pfizer
   Australia; Sanofi Australia; Celgene Australian & NZ and Bristol-Myers
   Squibb Australia Pty Ltd. Previous sponsorship for ARAD included an
   Australian National Health and Medical Research Council (NHMRC) Enabling
   Grant, Amgen Australia Pty Ltd, Aventis, AstraZeneca, Roche, Monash
   University and Cabrini Health. Infrastructure support for ARAD was
   received from Cabrini Health, Monash University, Royal North Shore
   Hospital and the Australian Rheumatology Association. P. Sinnathurai is
   supported by a NHMRC Postgraduate Scholarship and was a recipient of the
   SA LSS Support Group Grant & Arthritis Australia & State and Territory
   Affiliate Grant funded by Arthritis South Australia. R. Buchbinder is
   funded by a NHMRC Senior Principal Research Fellowship.
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NR 46
TC 23
Z9 26
U1 0
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1444-0903
EI 1445-5994
J9 INTERN MED J
JI Intern. Med. J.
PD NOV
PY 2018
VL 48
IS 11
BP 1360
EP 1368
DI 10.1111/imj.14046
PG 9
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA GZ9SS
UT WOS:000449842300011
PM 30047189
DA 2025-06-11
ER

PT J
AU Fabbian, F
   Zucchi, B
   De Giorgi, A
   Tiseo, R
   Boari, B
   Salmi, R
   Cappadona, R
   Gianesini, G
   Bassi, E
   Signani, F
   Raparelli, V
   Basili, S
   Manfredini, R
AF Fabbian, Fabio
   Zucchi, Beatrice
   De Giorgi, Alfredo
   Tiseo, Ruana
   Boari, Benedetta
   Salmi, Raffaella
   Cappadona, Rosaria
   Gianesini, Gloria
   Bassi, Erika
   Signani, Fulvia
   Raparelli, Valeria
   Basili, Stefania
   Manfredini, Roberto
TI Chronotype, gender and general health
SO CHRONOBIOLOGY INTERNATIONAL
LA English
DT Article
DE chronobiology; circadian rhythm; chronotype; education; gender; health;
   psychopathology; sleep; school
ID POOR SLEEP QUALITY; COMMON MENTAL-DISORDERS; MORNINGNESS-EVENINGNESS;
   SOCIAL JETLAG; COLLEGE-STUDENTS; YOUNG-ADULTS; CIRCADIAN PREFERENCE;
   ACADEMIC-ACHIEVEMENT; DAYTIME SLEEPINESS; COGNITIVE PERFORMANCE
AB Background: Light-dark alternation has always been the strongest external circadian zeitgeber for humans. Due to its growing technological preference, our society is quickly transforming toward a progressive eveningness (E), with consequences on personal circadian preference (chronotype), depending on gender as well. The aim of this study was to review the available evidence of possible relationships between chronotype and gender, with relevance on disturbances that could negatively impact general health, including daily life aspects. Methods: Electronic searches of the published literature were performed in the databases MEDLINE and Web of Science, by using the Medical Subject Heading (MeSH), when available, or other specific keywords. Results: Results were grouped into four general areas, i.e. (a) General and Cardiovascular Issues, (b) Psychological and Psychopathological Issues, (c) Sleep and Sleep-Related Issues and (d) School and School-Related Issues. (a) E is associated with unhealthy and dietary habits, smoking and alcohol drinking (in younger subjects) and, in adults, with diabetes and metabolic syndrome; (b) E is associated with impulsivity and anger, depression, anxiety disorders and nightmares (especially in women), risk taking behavior, use of alcohol, coffee and stimulants, psychopathology and personality traits; (c) E has been associated, especially in young subjects, with later bedtime and wake-up time, irregular sleep-wake schedule, subjective poor sleep, school performance and motivation, health-related quality of life; (d) E was associated with lowest mood and lower overall grade point average (especially for women). Conclusions: Eveningness may impact general health, either physical or mental, sleep, school results and achievements, especially in younger age and in women. The role of family support is crucial, and parents should be deeply informed that abuse of technological devices during night hours may lead to the immature adjustment function of children's endogenous circadian pacemakers.
C1 [Fabbian, Fabio; Zucchi, Beatrice; De Giorgi, Alfredo; Cappadona, Rosaria; Manfredini, Roberto] Univ Ferrara, Sch Med, I-44121 Ferrara, Italy.
   [Fabbian, Fabio; De Giorgi, Alfredo; Tiseo, Ruana; Boari, Benedetta; Salmi, Raffaella; Gianesini, Gloria; Bassi, Erika; Manfredini, Roberto] Azienda Osped Univ, Ferrara, Italy.
   [Signani, Fulvia] Azienda Unita Sanitaria Locale Ferrara, Ferrara, Italy.
   [Signani, Fulvia] Univ Ferrara, I-44121 Ferrara, Italy.
   [Raparelli, Valeria] Sapienza Univ Rome, Rome, Italy.
C3 University of Ferrara; University of Ferrara; Arcispedale Sant'Anna;
   University of Ferrara; Sapienza University Rome
RP Fabbian, F (corresponding author), Univ Ferrara, Clin Med Unit, Sch Med, Via L Ariosto 35, I-44121 Ferrara, Italy.
EM f.fabbian@ospfe.it
RI Boari, Benedetta/AAB-4792-2022; CAPPADONA, ROSARIA/HGB-7697-2022;
   Raparelli, Valeria/AAC-2228-2019; Bassi, Erika/AAO-1021-2021; De Giorgi,
   Alfredo/AAB-9926-2022; Manfredini, Roberto/A-3471-2008; Basili,
   Stefania/K-4024-2016; Signani, Fulvia/O-5294-2016; Fabbian,
   Fabio/G-1198-2015
OI Manfredini, Roberto/0000-0002-8364-2601; Basili,
   Stefania/0000-0002-6987-1926; Boari, Benedetta/0000-0002-9015-7858;
   Signani, Fulvia/0000-0003-4672-8948; Fabbian, Fabio/0000-0001-5189-3695;
   Bassi, Erika/0000-0001-6031-1271; Raparelli,
   Valeria/0000-0002-2100-5682; De Giorgi, Alfredo/0000-0002-0903-7825;
   CAPPADONA, Rosaria/0000-0003-3254-6043
FU University of Ferrara (FAR - Fondo Ateneo Ricerca)
FX This study has been supported, in part, by a scientific grant from the
   University of Ferrara (FAR - Fondo Ateneo Ricerca)
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NR 109
TC 203
Z9 219
U1 5
U2 81
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 0742-0528
EI 1525-6073
J9 CHRONOBIOL INT
JI Chronobiol. Int.
PY 2016
VL 33
IS 7
BP 863
EP 882
DI 10.1080/07420528.2016.1176927
PG 20
WC Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Life Sciences & Biomedicine - Other Topics; Physiology
GA DS6HU
UT WOS:000380883700008
PM 27148626
OA Green Published
DA 2025-06-11
ER

PT J
AU Pavlidou, E
   Fasoulas, A
   Mantzorou, M
   Giaginis, C
AF Pavlidou, Eleni
   Fasoulas, Aristeidis
   Mantzorou, Maria
   Giaginis, Constantinos
TI Clinical Evidence on the Potential Beneficial Effects of Probiotics and
   Prebiotics in Cardiovascular Disease
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE cardiovascular disease; clinical studies; gut microbiota; prebiotics;
   probiotics; coronary artery disease; stroke; hypertension
ID LACTOBACILLUS-PLANTARUM 299V; GUT MICROBIOTA; BLOOD-PRESSURE;
   ENDOTHELIAL FUNCTION; CASEI SHIROTA; NITRIC-OXIDE; BARRIER;
   HYPERTENSION; SUPPLEMENTATION; INFLAMMATION
AB The 'gut microbiome'-the hundreds of trillions of bacteria in the human gastrointestinal tract-serves several functions. The gut microbiome includes all the microorganisms, bacteria, viruses, protozoa, and fungi in the gastrointestinal tract and their genetic material. It helps digest indigestible foods and produces nutrients. Through the metabolism of sugars and proteins, it helps the intestinal barrier, the immune system, and metabolism. Some bacteria, such as those in the gut microbiome, cause disease, but others are essential to our health. These "good" microbes protect us from pathogens. Numerous studies have linked an unhealthy gut microbiome to obesity, insulin resistance, depression, and cardiometabolic risk factors. To maximize probiotic benefits in each case, knowledge of probiotic bacterial strains and how to consume them should be increased. This study aims to examine the benefits of probiotic and prebiotic organisms on cardiovascular health, specifically on heart disease, coronary heart disease, stroke, and hypertension. To complete the research, a literature review was conducted by gathering clinical studies and data. The clinical evidence demonstrates the beneficial effect of probiotics and prebiotic microorganisms on the gut microbiome, which has multiple benefits for overall health and especially for cardiovascular diseases.
C1 [Pavlidou, Eleni; Fasoulas, Aristeidis; Mantzorou, Maria; Giaginis, Constantinos] Univ Aegean, Sch Environm, Dept Food Sci & Nutr, Lemnos 81400, Greece.
RP Giaginis, C (corresponding author), Univ Aegean, Sch Environm, Dept Food Sci & Nutr, Lemnos 81400, Greece.
EM cgiaginis@aegean.gr
RI Pavlidou, Eleni/JMB-5502-2023; Giaginis, Constantinos/JMQ-9552-2023
OI Giaginis, Constantinos/0000-0003-2878-4831; Pavlidou,
   Eleni/0000-0002-7764-3544
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NR 95
TC 20
Z9 22
U1 3
U2 26
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD DEC
PY 2022
VL 23
IS 24
AR 15898
DI 10.3390/ijms232415898
PG 12
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 7E5OB
UT WOS:000901216000001
PM 36555535
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Stanczak, NA
   Grywalska, E
   Dudzinska, E
AF Stanczak, Natalia Anna
   Grywalska, Ewelina
   Dudzinska, Ewa
TI The latest reports and treatment methods on polycystic ovary syndrome
SO ANNALS OF MEDICINE
LA English
DT Review
DE Polycystic ovary syndrome; PCOS; hyperandrogenism; hyperinsulinaemia;
   insulin resistance; treatment of PCOS
ID IMPAIRED GLUCOSE-TOLERANCE; VITAMIN-D SUPPLEMENTATION; DOUBLE-BLIND;
   OXIDATIVE STRESS; OVULATION INDUCTION; INSULIN-RESISTANCE;
   CO-SUPPLEMENTATION; METABOLIC SYNDROME; LIPID PROFILES; NIGELLA-SATIVA
AB Aim: Polycystic ovary syndrome (PCOS) is an increasingly recognized endocrine disorder. The pathogenesis is not fully known. Polycystic ovary syndrome is still difficult to diagnose correctly, despite simple diagnostic criteria. The aim of the study is to review the current knowledge about PCOS and treatment options for patients with the disease. To explore this topic, publications were reviewed and conclusions drawn from them. The incidence of hyperandrogenism in a patient with PCOS may be as high as 60-80%. Increased androgen levels affect ovulation and menstruation, and also result in hirsutism and acne. Additionally, patients have problems with proper glucose tolerance (insulin resistance), type 2 diabetes, hypertension, cardiovascular diseases and metabolic syndrome. PCOS results in various symptoms in patients.Methods: The latest treatment methods were analysed. A standard review of publications in the field of diagnosis and treatment of PCOS, IR and hyperandrogenism was used.Results: Lifestyle, especially diet, deserves special attention due to its ease of use. Sleep quality, physical activity and stress reduction are also important. Diet should be the treatment of first choice. Only if dietary intervention does not bring results, the doctor considers pharmacotherapy. Recently, acupuncture and herbal medicine, vagus nerve stimulation have been used in the treatment of PCOS and regulation of hormone levels. Patients are given supplementation to improve the quality of functioning, but it must be remembered that inappropriate doses or too long use may result in a toxic effect opposite to the therapeutic one.Conclusion: Appropriate diet, physical activity - lifestyle changes are crucial in the treatment of PCOS. Supplementation and pharmaceuticals support treatment. It is mandatory to examine these environmental and lifestyle factors as they not only contribute to the occurrence of the disease but also influence its progression.
   Polycystic ovary syndrome (PCOS) is a complex metabolic and hormonal disorder that occurs in women. It manifests itself in menstrual disorders, changes in appearance related to excessive hair growth and acne. PCOS is also associated with the risk of other diseases, glucose tolerance (insulin resistance), type 2 diabetes, hypertension, cardiovascular diseases and metabolic syndrome. Polycystic ovary syndrome is still difficult to diagnose correctly, despite simple diagnostic criteria.The symptoms and course of the disease vary, specific to each patient. Patients struggle with PCOS, not being aware that it is a significant medical problem. The patients have always had problems with menstruation, so they think it is normal.The article reviews and describes various treatment methods: Hormone therapy, pharmacological methods, supplementation, non-pharmacological methods such as herbal medicine, acupuncture.
C1 [Stanczak, Natalia Anna; Dudzinska, Ewa] Med Univ Lublin, Dept Dietary & Nutr Educ, Chodzki 7, PL-20093 Lublin, Poland.
   [Grywalska, Ewelina] Med Univ Lublin, Dept Expt Immunol, Lublin, Poland.
C3 Medical University of Lublin; Medical University of Lublin
RP Stanczak, NA (corresponding author), Med Univ Lublin, Dept Dietary & Nutr Educ, Chodzki 7, PL-20093 Lublin, Poland.
EM stanczaknatali@gmail.com
RI Grywalska, Ewelina/MSX-0772-2025; Dudzińska, Ewa/AAO-5248-2020
FU Medical University of Lublin [DS640]
FX This work is supported by the Medical University of Lublin under Grant
   Number DS640.
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NR 120
TC 14
Z9 14
U1 10
U2 47
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0785-3890
EI 1365-2060
J9 ANN MED
JI Ann. Med.
PD DEC 31
PY 2024
VL 56
IS 1
AR 2357737
DI 10.1080/07853890.2024.2357737
PG 21
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA XM6Q3
UT WOS:001262144500001
PM 38965663
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Hur, S
   Kim, SR
   Cho, BJ
AF Hur, Sun
   Kim, Seon-Rye
   Cho, Byung-Jun
TI Comparison of the Effects of Exercise Participation on Psychosocial Risk
   Factors and Cardiovascular Disease in Women
SO JOURNAL OF PHYSICAL THERAPY SCIENCE
LA English
DT Article
DE Psychological; Personality; Exercise
ID CHRONIC HEART-FAILURE; CORONARY-ARTERY-DISEASE; D PERSONALITY CONSTRUCT;
   CARDIAC REHABILITATION; METABOLIC SYNDROME; IMMUNE ACTIVATION;
   LIFE-STYLE; PSYCHONEUROIMMUNOLOGY; PREVALENCE; PROFILE
AB [Purpose] The aim of this study was to research the association of Type D personality with CVD risk factors and psychology through comparison of the association of exercise participation with CVD risk factors and psychological risk factors in women with Type D. [Subjects] This study included 416 middle-aged women. All participants completed the 14-item Type D Scale (DS14) to assess Type D personality. The DS14 consists of two subscales, NA and SI, both of which comprise 7 items. The research subjects were randomly assigned to four groups: Type D+Exercise (n=12), Type D+non-Exercise (n=12), non-Type D+Exercise (n=12), non-Type D+non-Exercise (n=10). The study consisted of 46 participants. [Methods] An aerobic exercise program and meditation were conducted in parallel for 10 months. Stretching was performed for 10 min as a warm-up, and then walking and running were performed on a treadmill at the HRmax 60-70% level for 40 min; this was done three times a week. Blood samples were processed according to standard laboratory procedures. The concentrations of TG and HDL-cholesterol were determined enzymatically on a clinical chemistry analyzer. Blood glucose was measured by the hexokinase method. [Results] Weight, percent fat, social support, and waist circumference showed a significant difference between times in the Exercise groups, and the values were significantly lower than those of the non-Exercise groups. Anxiety and depression showed a significant interaction effect between groups. The average number of CVD risk factors in subjects showed a significant difference between groups. [Conclusion] In conclusion, there were significant differences between groups in terms of CVD risk factors and psychological risk factors in women with Type D personality.
C1 [Hur, Sun] Kangwon Natl Univ, Div Sport Sci, Kyudong Samcheok City 245711, Kangwondo, South Korea.
   [Kim, Seon-Rye] Chungnam Natl Univ, Coll Pharm, Taejon, South Korea.
   [Cho, Byung-Jun] Kangwon Natl Univ, Dept Emergency Med Technol, Kyudong Samcheok City 245711, Kangwondo, South Korea.
C3 Kangwon National University; Chungnam National University; Kangwon
   National University
RP Cho, BJ (corresponding author), Kangwon Natl Univ, Dept Emergency Med Technol, Kyudong Samcheok City 245711, Kangwondo, South Korea.
EM Cho6451@gmail.com
RI Kim, Seon-Rye/GXN-3562-2022
OI Kim, Seon-Rye/0000-0002-3496-273X
CR [Anonymous], AM J CARDIOL
   소위영, 2007, [Exercise Science, 운동과학], V16, P85
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NR 27
TC 5
Z9 6
U1 0
U2 16
PU SOC PHYSICAL THERAPY SCIENCE
PI TOKYO
PA C/O PUBLICATION CENTER, 1-24-12 SUGAMO, TOSHIMA-KU, TOKYO, 170-0002,
   JAPAN
SN 0915-5287
EI 2187-5626
J9 J PHYS THER SCI
JI J. Phys. Ther. Sci.
PD NOV
PY 2014
VL 26
IS 11
BP 1795
EP 1798
DI 10.1589/jpts.26.1795
PG 4
WC Rehabilitation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Rehabilitation
GA AY3JH
UT WOS:000347479600031
PM 25435703
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Bond, DJ
   Andreazza, AC
   Hughes, J
   Dhanoa, T
   Torres, IJ
   Kozicky, JM
   Youngs, LT
   Lam, RW
   Yatham, LN
AF Bond, David J.
   Andreazza, Ana C.
   Hughes, John
   Dhanoa, Taj
   Torres, Ivan J.
   Kozicky, Jan-Marie
   Youngs, L. Trevor
   Lam, Raymond W.
   Yatham, Lakshmi N.
TI Association of peripheral inflammation with body mass index and
   depressive relapse in bipolar disorder
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE Bipolar disorder; Body mass index; Obesity; Cytokines; Inflammation;
   Relapse
ID TASK-FORCE RECOMMENDATIONS; BLOOD-BRAIN-BARRIER; METABOLIC SYNDROME;
   ANXIETY DISORDERS; 1ST-EPISODE MANIA; CANADIAN NETWORK; MOOD DISORDERS;
   OBESITY; MARKERS; METAANALYSIS
AB Bipolar I disorder (BD) is associated with increased inflammation, which is believed to be central to disease etiology and progression. However, BD patients also have high rates of obesity, itself an inflammatory condition, and the relative contributions of mood illness and obesity to inflammation are unknown. Moreover, the impact of inflammation on clinical illness course has not been well studied. The objectives of this analysis were therefore: (1) to determine if inflammation in BD is mood illness-related or secondary to elevated body mass index (BMI), and (2) to investigate the impact of inflammation on prospectively-ascertained relapse into depression and mania. We measured the serum levels of 7 inflammatory cytokines (TNF-alpha, gamma-interferon, monocyte chemoattractant protein-1 [MCP-1], IL-1 alpha, IL-2, IL-6, and IL-8) and 2 anti-inflammatory cytokines (IL-4 and IL-10) in 52 early-stage BD patients and 22 healthy subjects. In patients, a multivariate multiple regression model that controlled for psychotropic medications found that higher BMI, but not recent (past-6-month) mood episodes, predicted greater inflammatory cytokines (p=.05). Healthy subjects also had a BMI-related increase in inflammatory cytokines (p<.01), but it was counter-balanced by a compensatory increase in anti-inflammatory cytokines (p=.02), reducing their total inflammatory burden from higher BMI. In patients, linear regression showed that two inflammatory cytokines predicted depressive relapse in the 12 months after cytokine measurement: IL-1 alpha (p<.01) and MCP-1 (p<.01). These results suggest that elevated BMI is a significant contributor to inflammation in BD, more so even than recent mood illness severity. They also point to inflammation as an important predictor of illness course, particularly depressive relapse. (C) 2015 Elsevier Ltd. All rights reserved.
C1 [Bond, David J.; Dhanoa, Taj; Torres, Ivan J.; Kozicky, Jan-Marie; Lam, Raymond W.; Yatham, Lakshmi N.] Univ British Columbia, Mood Disorders Ctr, 2255 Wesbrook Mall, Vancouver, BC V6T 2A1, Canada.
   [Bond, David J.] Univ Minnesota, Dept Psychiat, 2450 Riverside Ave, Minneapolis, MN 55454 USA.
   [Andreazza, Ana C.; Youngs, L. Trevor] Univ Toronto, Dept Psychiat, 250 Coll St, Toronto, ON M5T 1R8, Canada.
   [Andreazza, Ana C.; Youngs, L. Trevor] Univ Toronto, Dept Pharmacol, 250 Coll St, Toronto, ON M5T 1R8, Canada.
   [Hughes, John] Univ Minnesota, Sch Publ Hlth, Div Biostat, 420 Delaware St, Minneapolis, MN 55455 USA.
C3 University of British Columbia; University of Minnesota System;
   University of Minnesota Twin Cities; University of Toronto; University
   of Toronto; University of Minnesota System; University of Minnesota Twin
   Cities
RP Yatham, LN (corresponding author), Univ British Columbia, Mood Disorders Ctr, Room 2C7-2255 Wesbrook Mall, Vancouver, BC V6T 2A1, Canada.
EM yatham@mail.ubc.ca
RI Hughes, John/IQT-6070-2023; Andreazza, Ana Cristina/P-8562-2018; Lam,
   Raymond W./D-2529-2013; Yatham, Lakshmi N/HCH-4139-2022
OI Hughes, John/0000-0003-1538-2569; Andreazza, Ana
   Cristina/0000-0002-4323-7273; Torres, Ivan/0000-0001-5107-3339; Bond,
   David/0000-0002-8713-7311; Lam, Raymond W./0000-0001-7142-4669; Yatham,
   Lakshmi N/0000-0002-7405-0954
FU AstraZeneca Canada; Pfizer Canada [WS1952848]
FX The data for this manuscript were generated from the Systematic
   Treatment Optimization Program for Early Mania (STOP-EM), which was
   supported by an unrestricted grant to LNY from AstraZeneca Canada. The
   analysis of serum cytokines was supported by an investigator-initiated
   grant (WS1952848) to DJB from Pfizer Canada. The sponsors had no input
   into the design or conduct of the study; the collection, management,
   analysis, or interpretation of the data; the preparation, review, or
   approval of the manuscript; or the decision to submit the manuscript for
   publication.
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NR 49
TC 32
Z9 36
U1 0
U2 17
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD MAR
PY 2016
VL 65
BP 76
EP 83
DI 10.1016/j.psyneuen.2015.12.012
PG 8
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA DE8QV
UT WOS:000370902500010
PM 26731572
DA 2025-06-11
ER

PT J
AU Phé, V
   Rouprêt, M
AF Phe, V.
   Roupret, M.
TI Erectile dysfunction and diabetes: A review of the current
   evidence-based medicine and a synthesis of the main available therapies
SO DIABETES & METABOLISM
LA English
DT Review
DE Diabetes; Erectile dysfunction; Endothelial dysfunction; Cardiovascular
   disease; Phosphodiesterase inhibitors; Intracavernous injection; Penile
   prosthesis; Review
ID CORONARY-ARTERY-DISEASE; CARDIOVASCULAR RISK-FACTORS; QUALITY-OF-LIFE;
   SEXUAL DYSFUNCTION; DOUBLE-BLIND; ENDOTHELIAL DYSFUNCTION; INHIBITOR
   TADALAFIL; SILDENAFIL CITRATE; METABOLIC SYNDROME; JAPANESE MEN
AB Aim. - This review aimed to provide an update of the epidemiology, pathophysiology and management of erectile dysfunction (ED) in diabetes patients.
   Methods. - Data on the management of ED in diabetes patients in the literature were analyzed using Medline, and by matching the following keywords: diabetes; erectile dysfunction; endothelial dysfunction; cardiovascular disease; phosphodiesterase inhibitors; intracavernous injection; and penile prosthesis.
   Results. - ED has a higher incidence in diabetic patients. The pathophysiology is multifactorial, involving endothelial dysfunction, specific complications of diabetes and psychological factors. Recent studies have shown that ED is able to predict future cardiovascular events not only in non-diabetics, but also in patients with diabetes. ED could also be a potential marker to screen for silent coronary artery disease. The management of ED has been revolutionized by the discovery of phosphodiesterase type-5 (PDE5) inhibitors, the first-line therapeutic options for diabetic men with ED that are efficient and safe. As a second line, intracavernous injections remain a gold-standard treatment, although a vacuum device can be used as well. In cases of failure, penile prosthesis may be considered. Hypogonadism, commonly found in diabetics, may require identification and treatment. Optimalized glycaemic control, management of associated co-morbidities and lifestyle modifications are essential in all patients. As ED and diabetes negatively impact male self-esteem, and generate depression and anxiety, the psychological treatment of patients is also likely to be beneficial.
   Conclusion. - The aetiology of diabetic ED is multifactorial. Endothelial dysfunction is the link between diabetes-induced ED and coronary artery disease. A global approach is needed for the successful management of diabetic ED. (C) 2011 Elsevier Masson SAS. All rights reserved.
C1 [Phe, V.; Roupret, M.] Univ Paris 06, Pitie Salpetriere Hosp, Assistance Publ Hop Paris, Urol & Androl Acad Dept,Fac Med Pierre & Marie Cu, F-75013 Paris, France.
C3 Assistance Publique Hopitaux Paris (APHP); Universite Paris Cite;
   Hopital Universitaire Saint-Louis - APHP; Hopital Universitaire
   Pitie-Salpetriere - APHP; Sorbonne Universite
RP Rouprêt, M (corresponding author), Univ Paris 06, Pitie Salpetriere Hosp, Assistance Publ Hop Paris, Urol & Androl Acad Dept,Fac Med Pierre & Marie Cu, 47-83 Blvd Hop, F-75013 Paris, France.
EM morgan.roupret@psl.aphp.fr
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NR 119
TC 83
Z9 97
U1 0
U2 20
PU MASSON EDITEUR
PI MOULINEAUX CEDEX 9
PA 21 STREET CAMILLE DESMOULINS, ISSY, 92789 MOULINEAUX CEDEX 9, FRANCE
SN 1262-3636
EI 1878-1780
J9 DIABETES METAB
JI Diabetes Metab.
PD FEB
PY 2012
VL 38
IS 1
BP 1
EP 13
DI 10.1016/j.diabet.2011.09.003
PG 13
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 905KO
UT WOS:000301271300001
PM 22056307
DA 2025-06-11
ER

PT J
AU Yu, SS
   Guo, XF
   Li, GX
   Yang, HM
   Zheng, LQ
   Sun, YX
AF Yu, Shasha
   Guo, Xiaofan
   Li, Guang Xiao
   Yang, Hongmei
   Zheng, Liqiang
   Sun, Yingxian
TI Metabolic syndrome associated with the onset of depressive symptoms
   among women but not men in rural Northeast China
SO BMC PSYCHIATRY
LA English
DT Article
DE Major depressive symptom; Gender difference; Incidence; MetS; Metabolic
   disorders
ID YOUNG-ADULTS; HEALTH; DISORDER; PREVALENCE; GENDER; URBAN; POPULATION;
   THERAPY; ANXIETY; RISK
AB Background The present study aimed to assess the cumulative incidence of major depressive disorder (MDD) among rural Chinese residents. Furthermore, we intended to estimate whether metabolic syndrome (MetS) was associated with MDD by both cross-sectional and prospective analysis. Method Data of 11,675 residents (46.3% men) was used for cross-sectional analysis. The residents were followed up with median 4.66 years. MDD was diagnosed using the Patient Health Questionnaire-9 (PHQ-9). The data of 2796 individuals without any depressive symptoms was used for prospective analysis. Result With median of 4.66 years follow-up, the cumulative incidence of MDD among rural residents was 3.9%. Women had significantly higher cumulative incidence of MDD than men (5.3% for women and 2.9% for men, P < 0.01). The incidence of MDD was significantly higher among women with MetS (7.3% vs. 3.8%, P < 0.001), hypertriglyceridemia (7.0% vs. 4.5%, P < 0.001) or elevated blood pressure (6.4% vs. 3.4%, P < 0.001) at baseline compared with those without them. There was no incidence difference of MDD among men with or without baseline metabolic disorders. In prospective study, after adjusting possible confounders, baseline MetS was associated with higher incidence of MDD (OR: 1.82, 95%CI: 1.01, 3.27, P = 0.045) in women but not men (OR: 1.84, 95%CI: 0.88, 3.83, P = 0.104). Conclusion Cumulative incidence of MDD in rural China was higher among women than among men. Baseline MetS was associated with higher cumulative incidence of MDD in women but not men. More concern should be put on women with MetS in case of onset depressive symptom in future.
C1 [Yu, Shasha; Guo, Xiaofan; Yang, Hongmei; Sun, Yingxian] China Med Univ, Dept Cardiol, Hosp 1, 155 Nanjing North St, Shenyang 110001, Peoples R China.
   [Li, Guang Xiao] China Med Univ, Dept Clin Epidemiol, Hosp 1, Inst Cardiovasc Dis, Shenyang 110001, Peoples R China.
   [Zheng, Liqiang] China Med Univ, Dept Clin Epidemiol, Shengjing Hosp, Shenyang 110004, Peoples R China.
C3 China Medical University; China Medical University; China Medical
   University
RP Sun, YX (corresponding author), China Med Univ, Dept Cardiol, Hosp 1, 155 Nanjing North St, Shenyang 110001, Peoples R China.
EM sunyingxiancmu1h@163.com
RI Sun, Yingxian/KHT-6171-2024
OI Sun, Yingxian/0000-0002-1961-899X
FU National Key Research and Development Program from the Ministry of
   Science and Technology of China [2018 YFC 1312400, 2018 YFC 1312403];
   National Natural Science Foundation of China [81800361]; China
   Scholarship Council [201908210044]
FX This study was supported by grants from the National Key Research and
   Development Program from the Ministry of Science and Technology of China
   (Project Grant # 2018 YFC 1312400, Sub-project Grant # 2018 YFC 1312403)
   and National Natural Science Foundation of China (Grant # 81800361).
   Shasha Yu is sponsored by the China Scholarship Council (File
   No.201908210044).
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NR 41
TC 5
Z9 6
U1 0
U2 6
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-244X
J9 BMC PSYCHIATRY
JI BMC Psychiatry
PD MAY 24
PY 2020
VL 20
IS 1
AR 254
DI 10.1186/s12888-020-02668-z
PG 10
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA LU4DD
UT WOS:000537706800002
PM 32448183
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Costemale-Lacoste, JF
   Trabado, S
   Verstuyft, C
   El Asmar, K
   Butlen-Bucuing, F
   Colle, R
   Ferreri, F
   Polosan, M
   Haffen, E
   Balkau, B
   Falissard, B
   Feve, B
   Becquemont, L
   Corruble, E
AF Costemale-Lacoste, Jean-Francois
   Trabado, Severine
   Verstuyft, Celine
   El Asmar, Khalil
   Butlen-Bucuing, Florence
   Colle, Romain
   Ferreri, Florian
   Polosan, Mircea
   Haffen, Emmanuel
   Balkau, Beverley
   Falissard, Bruno
   Feve, Bruno
   Becquemont, Laurent
   Corruble, Emmanuelle
TI Severe insomnia is associated with hypertriglyceridemia in women with
   major depression treated in psychiatry settings
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Major depressive disorder; Insomnia; Severe insomnia; Triglyceridemia;
   Hypertriglyceridemia; Cardiovascular risk
ID METABOLIC SYNDROME; SLEEP DURATION; DYSLIPIDEMIA; DISORDER; IMPACT
AB Background: Hypertriglyceridemia (HTG) is a cardiovascular risk factor. In the general population, elevated fasting triglyceridemia (TG) is associated with insomnia. Since insomnia is a core symptom of Major Depressive Episodes (MDE), we studied the association of severe insomnia with HTG in major depression.
   Methods: We used the baseline data of the METADAP cohort, comprising 624 patients with a current MDE in a context of Major Depressive Disorder treated in psychiatry settings, without current alcohol use disorders. Patients were screened for severe insomnia, defined by a score of four or more on the three Hamilton Depression Rating Scale (HDRS) sleep items, and for HTG characterised by TG >= 200 mg/dL.
   Results: Severe insomnia was observed in 335(54%) patients with a current MDE, of whom 234(70%) were women; 49(8%) patients had HTG, of whom 25(51%) were women. 69(11%) patients were treated with lipid lowering drugs. Severe insomnia was associated with a higher frequency of HTG in the whole sample (9.9% vs 5.6%, p = 0.046) and in the subgroup of women (9.0% vs 2.0%, p = 0.002). Multivariate logistic regression analyses adjusted for age, education levels, EMI and total HDRS scores confirmed the association between severe insomnia and HTG in the whole sample (OR=2.02, 95%CI [1.00-4.08], p = 0.05) as well as in the subgroup of women (OR = 4.82, 95%CI [1.5-15.5], p=0.008). No association was shown in men.
   Perspectives: HTG should be systematically investigated in depressed patients with severe insomnia and particularly in women. Further studies are needed to explain the association we observed between severe insomnia and HTG.
C1 [Costemale-Lacoste, Jean-Francois; Verstuyft, Celine; El Asmar, Khalil; Butlen-Bucuing, Florence; Colle, Romain; Becquemont, Laurent; Corruble, Emmanuelle] INSERM UMRS 1178, Team Depress & Antidepressants, F-94275 Le Kremlin Bicetre, France.
   [Costemale-Lacoste, Jean-Francois; Trabado, Severine; Verstuyft, Celine; Butlen-Bucuing, Florence; Colle, Romain; Becquemont, Laurent; Corruble, Emmanuelle] Univ Paris Sud, Fac Med, F-94275 Le Kremlin Bicetre, France.
   [Costemale-Lacoste, Jean-Francois; Butlen-Bucuing, Florence] Hop Univ Paris Sud, Serv Psychiat, Hop Bicetre, AP HP, F-94275 Le Kremlin Bicetre, France.
   [Trabado, Severine] Univ Paris Saclay, Fac Med Paris Sud, INSERM, F-94276 Le Kremlin Bicetre, France.
   [Trabado, Severine; Verstuyft, Celine; Becquemont, Laurent; Corruble, Emmanuelle] Hop Univ Paris Sud, Serv Genet Mol, Pharmacogenet & Hormonol, Hop Bicetre, F-94275 Le Kremlin Bicetre, France.
   [Verstuyft, Celine; Becquemont, Laurent] Univ Paris Sud, CRP Paris Sud Hop, Ctr Resources Biol, AP HP, F-94275 Le Kremlin Bicetre, France.
   [Ferreri, Florian] Univ Paris 06, Paris, France.
   [Ferreri, Florian] Hop St Antoine, Psychiat Serv, Paris, France.
   [Polosan, Mircea] Univ Bourgogne Franche Comte, Univ Hosp Besancon, CIC INSERM 1431, Dept Clin Psychiat, Besancon, France.
   [Haffen, Emmanuel] Univ Franche Comte, Lab Integrat & Clin Neurosci, EA 481, COMUE Bourgogne Franche Comte, Paris, France.
   [Balkau, Beverley] UVSQ UPS, INSERM UMR 1178, CESP, Renal & Cardiovasc Epidemiol, Villejuif, France.
   [Falissard, Bruno] Univ Paris Sud, Dept Biostat, INSERM UMR 1178, CESP, F-94400 Villejuif, France.
   [Feve, Bruno] Hop St Antoine, AP HP, Serv Endocrinol, Paris, France.
   [Feve, Bruno] Univ Paris 06, Sorbonne Univ, INSERM UMR S 938, Ctr Rech St Antoine, Paris, France.
C3 Institut National de la Sante et de la Recherche Medicale (Inserm);
   Universite Paris Cite; Universite Paris Saclay; Assistance Publique
   Hopitaux Paris (APHP); Hopital Universitaire Antoine-Beclere - APHP;
   Universite Paris Saclay; Hopital Universitaire Bicetre - APHP;
   Universite Paris Saclay; Institut National de la Sante et de la
   Recherche Medicale (Inserm); Assistance Publique Hopitaux Paris (APHP);
   Hopital Universitaire Antoine-Beclere - APHP; Hopital Universitaire
   Bicetre - APHP; Universite Paris Saclay; Assistance Publique Hopitaux
   Paris (APHP); Hopital Universitaire Bicetre - APHP; Universite Paris
   Saclay; Sorbonne Universite; Assistance Publique Hopitaux Paris (APHP);
   Sorbonne Universite; Hopital Universitaire Saint-Antoine - APHP;
   Universite de Franche-Comte; CHU Besancon; Institut National de la Sante
   et de la Recherche Medicale (Inserm); Universite de Franche-Comte;
   Universite Paris Saclay; Universite Paris Cite; Institut National de la
   Sante et de la Recherche Medicale (Inserm); Universite Paris Cite;
   Institut National de la Sante et de la Recherche Medicale (Inserm);
   Universite Paris Saclay; Assistance Publique Hopitaux Paris (APHP);
   Sorbonne Universite; Hopital Universitaire Saint-Antoine - APHP;
   Institut National de la Sante et de la Recherche Medicale (Inserm);
   Sorbonne Universite
RP Costemale-Lacoste, JF (corresponding author), INSERM UMRS 1178, Team Depress & Antidepressants, F-94275 Le Kremlin Bicetre, France.
EM jean-francois.costemale-lacoste@aphp.fr
RI Rouquette, Alexandra/AGY-2116-2022; becquemont, laurent/KLD-8162-2024;
   Colle, romain/D-9144-2017; verstuyft, celine/AAU-3343-2021; Bonnet,
   Fabrice/G-4255-2017; Polosan, Mircea/MGV-2270-2025; COSTEMALE-LACOSTE,
   Jean-François/ABG-5308-2020; haffen, emmanuel/R-2765-2017;
   Butlen-Ducuing, Florence/JJE-3926-2023
OI Feve, Bruno/0000-0001-6577-9009; haffen, emmanuel/0000-0002-4091-518X;
   Colle, Romain/0000-0002-2549-4495; verstuyft,
   celine/0000-0002-8534-224X; Butlen-Ducuing,
   Florence/0000-0002-8305-2089; Trabado, Severine/0000-0002-1925-1999
CR [Anonymous], 2012, DEPRESSION GLOB CRIS
   Balkau B, 2003, DIABETES METAB, V29, P526, DOI 10.1016/S1262-3636(07)70067-8
   Bjorvatn B, 2007, J SLEEP RES, V16, P66, DOI 10.1111/j.1365-2869.2007.00569.x
   Chien KL, 2010, SLEEP, V33, P177, DOI 10.1093/sleep/33.2.177
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NR 20
TC 8
Z9 8
U1 0
U2 7
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD AUG
PY 2017
VL 217
BP 159
EP 162
DI 10.1016/j.jad.2017.04.011
PG 4
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA EY4YE
UT WOS:000403983200024
PM 28411504
DA 2025-06-11
ER

PT J
AU Araújo, N
   Costa, A
   Lopes-Conceiçao, L
   Ferreira, A
   Carneiro, F
   Oliveira, J
   Braga, 
   Morais, S
   Pacheco-Figueiredo, L
   Ruano, L
   Cruz, VT
   Pereira, S
   Lunet, N
AF Araujo, N.
   Costa, A.
   Lopes-Conceicao, L.
   Ferreira, A.
   Carneiro, F.
   Oliveira, J.
   Braga, I
   Morais, S.
   Pacheco-Figueiredo, L.
   Ruano, L.
   Cruz, V. T.
   Pereira, S.
   Lunet, N.
TI Androgen-deprivation therapy and cognitive decline in the NEON-PC
   prospective study during the COVID-19 pandemic
SO ESMO OPEN
LA English
DT Article
DE prostate cancer; neurocognitive disorders; longitudinal studies;
   hormones; hormone substitutes; hormone antagonists/analogues and
   derivatives; COVID-19; complications
ID PROSTATE-CANCER; METABOLIC SYNDROME; DEPRESSION; DIAGNOSIS; ANXIETY;
   SLEEP; MOCA
AB Background: Androgen-deprivation therapy (ADT) has been associated with cognitive decline, but results are conflicting. This study describes changes in cognitive performance in patients with prostate cancer, according to ADT, during the first year after prostate cancer diagnosis.
   Patients and methods: Patients with prostate cancer treated at the Portuguese Institute of Oncology of Porto (n = 366) were evaluated with the Montreal Cognitive Assessment (MoCA), before treatment and after 1 year. All baseline evaluations were performed before the coronavirus disease 2019 (COVID-19) pandemic and 69.7% of the 1-year assessments were completed after the first lockdown. Cognitive decline was defined as the decrease in MoCA from baseline to the 1-year evaluation below 1.5 standard deviations of the distribution of changes in the whole cohort. Participants scoring below age- and education-specific normative reference values in the MoCA were considered to have cognitive impairment. Age- and education-adjusted odds ratios (aORs) were computed for the association between ADT and cognitive outcomes.
   Results: Mean MoCA scores increased from baseline to the 1-year evaluation (22.3 versus 22.8, P < 0.001). Cognitive decline was more frequent in the ADT group, and even more after the onset of the COVID-19 pandemic (aOR 6.81 versus 1.93, P for interaction = 0.233). The 1-year cumulative incidence of cognitive impairment was 6.9% (9.1% before and 3.7% after the pandemic onset), which was higher among patients receiving ADT, but only after the pandemic (aOR 5.53 versus 0.49, P for interaction = 0.044).
   Conclusions: ADT was associated with worse cognitive performance of patients with prostate cancer, mostly among those evaluated after the first COVID-19 lockdown.
C1 [Araujo, N.; Costa, A.; Lopes-Conceicao, L.; Morais, S.; Ruano, L.; Cruz, V. T.; Pereira, S.; Lunet, N.] Univ Porto, EPIUnit Inst Saude Publ, Porto, Portugal.
   [Araujo, N.; Costa, A.; Morais, S.; Ruano, L.; Cruz, V. T.; Pereira, S.; Lunet, N.] Lab Invest Integrat & Translac Saude Populac ITR, Porto, Portugal.
   [Ferreira, A.; Carneiro, F.; Oliveira, J.; Braga, I; Pereira, S.] Inst Portugues Oncol Porto, Rua Dr Antonio Bernardino de Almeida, Porto, Portugal.
   [Pacheco-Figueiredo, L.] Univ Minho, Inst Invest Ciencias Vida & Saude, Escola Med, Campus Gualtar, Braga, Portugal.
   [Lunet, N.] Univ Porto, Dept Ciencias Saude Publ & Forenses & Educ Med, Fac Med, Alameda Prof Hernani Monteiro, P-4200319 Porto, Portugal.
C3 Universidade do Porto; Universidade do Minho; Universidade do Porto
RP Lunet, N (corresponding author), Univ Porto, Dept Ciencias Saude Publ & Forenses & Educ Med, Fac Med, Alameda Prof Hernani Monteiro, P-4200319 Porto, Portugal.
EM nlunet@med.up.pt
RI Morais, Samantha/AGN-7196-2022; Araújo, Natália/AAS-8656-2021; Ruano,
   Luis/AAQ-6140-2020; Pacheco-Figueiredo, Luis/B-3004-2015; Tedim Cruz,
   Vitor/AAM-3014-2020
OI Pacheco-Figueiredo, Luis/0000-0002-0581-3663; Ruano,
   Luis/0000-0002-0903-494X; Campos Braga, Isaac/0000-0001-9265-4324;
   Costa, Adriana/0000-0003-2588-8141; Tedim Cruz,
   Vitor/0000-0002-5333-4771; pereira, susana/0000-0002-0593-262X; Morais,
   Samantha/0000-0001-5808-0179; Lunet, Nuno/0000-0003-1870-1430
FU European Regional Development Fund through the Operational Programme
   Competitiveness and Internationalisation; Fundacao para a Ciencia e a
   Tecnologia -FCT (Portuguese Ministry of Science, Technology and Higher
   Education) [POCI-01-0145-FEDER-032358, PTDC/SAU-EPI/32358/2017]; Unidade
   de Investigacao em Epidemiologia -Instituto de Saude Publica da
   Universidade do Porto (EPIUnit) [UIDB/04750/2020]; Laboratorio para a
   Investigacao Integrativa e Translacional em Saude Populacional - FCT
   [LA/P/0064/2020]; FCT [SFRH/BD/119390/2016]; `Programa Operacional
   Capital Humano' (POCH/FSE); project 'NEON-PC -Neuro-oncological
   complications of prostate cancer: longitudinal study of cognitive
   decline' [POCI-01-0145-FEDER-032358, PTDC/SAU-EPI/32358/2017]; Fundação
   para a Ciência e a Tecnologia [PTDC/SAU-EPI/32358/2017] Funding Source:
   FCT
FX This study was funded by the European Regional Development Fund through
   the Operational Programme Competitiveness and Internationalisation, and
   national funding from the Fundacao para a Ciencia e a Tecnologia -FCT
   (Portuguese Ministry of Science, Technology and Higher Education) under
   the project 'NEON-PC -Neuro-oncological complications of prostate
   cancer: longitudinal study of cognitive decline'
   (POCI-01-0145-FEDER-032358; Ref. PTDC/SAU-EPI/32358/2017), and the
   Unidade de Investigacao em Epidemiologia -Instituto de Saude Publica da
   Universidade do Porto (EPIUnit; UIDB/04750/2020) and Laboratorio para a
   Investigacao Integrativa e Translacional em Saude Populacional
   (LA/P/0064/2020), financed by national funds from FCT. AC and SM were
   funded under the scope of the project 'NEON-PC -Neuro-oncological
   complications of prostate cancer: longitudinal study of cognitive
   decline' (POCI-01-0145-FEDER-032358; Ref. PTDC/SAU-EPI/32358/2017). An
   individual PhD grant attributed to NA (SFRH/BD/119390/2016) was funded
   by FCT and the `Programa Operacional Capital Humano' (POCH/FSE).
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NR 41
TC 6
Z9 6
U1 0
U2 2
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
EI 2059-7029
J9 ESMO OPEN
JI ESMO Open
PD APR
PY 2022
VL 7
IS 2
DI 10.1016/j.esmoop.2022.100448
EA MAR 2022
PG 8
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA 1J4MJ
UT WOS:000797892800015
PM 35344749
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU García-Ulloa, AC
   Pérez-Peralta, L
   Lugo-Bautista, K
   Martínez-Sánchez, VA
   Mehta, R
   Hernández-Jiménez, S
AF Garcia-Ulloa, Ana Cristina
   Perez-Peralta, Liliana
   Lugo-Bautista, Karla
   Martinez-Sanchez, Victor A.
   Mehta, Roopa
   Hernandez-Jimenez, Sergio
CA CAIPaDi Study Grp
TI Metabolic Comorbidities Among Relatives of Type 2 Diabetes Patients
   Stratified by Weight Implications for Prevention and Care
SO DIABETES METABOLIC SYNDROME AND OBESITY
LA English
DT Article
DE obesity; metabolic diseases; relatives; body mass index; diabetes
   prevention
ID BODY-MASS INDEX; OBESITY; RISK; MORTALITY; OVERWEIGHT; HISTORY
AB Introduction: Diabetes, affecting 18.3% of young adults in Mexico (6), is influenced by both genetic factors and shared unhealthy habits within families. Objective: To determine the metabolic abnormalities in relatives of people with T2D, stratified by body mass index. Materials and Methods: This observational, descriptive study was conducted at the Center for Comprehensive Care for Patients with Diabetes (CAIPaDi). The study involved relatives of participants with type 2 diabetes mellitus (T2DM), recruited between June 2017 and December 2020. The relatives were people without diabetes, including spouses, siblings, offspring, or close family members aged 18 to 65 who spent over four days a week with the patient. Exclusion criteria included relatives diagnosed with diabetes, smokers, or any individual from a patient-relative pair that was excluded. All participants underwent laboratory tests and body measurements. Relatives were classified into three groups based on body weight: normal weight, overweight, and obesity. The relatives attended four monthly visits and then annual evaluations. Ethical approval was obtained. Results: The study enrolled 220 relatives of people with T2DM, 69% women, median age 49 +/- 12 years; 19.5% with normal weight, 40.4% overweight, and 40% with obesity. Prediabetes (39.4%), dyslipidemia (67.2%), and abnormal liver function tests (32.2%) were prevalent. Higher levels of triglycerides and LDL cholesterol were associated with increased risk for comorbid conditions. Anxiety and depression showed no significant differences across weight categories. Conclusion: These results highlight the importance of overweight and obesity as factors associated with the presence of comorbidities and the metabolic syndrome. It is essential to implement strategies to promote healthy habits among family members of people with diabetes, especially in those who are overweight or obese to reduce the risk of developing future metabolic and cardiovascular diseases.
C1 [Garcia-Ulloa, Ana Cristina; Perez-Peralta, Liliana; Hernandez-Jimenez, Sergio] Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Ctr Atenc Integral Paciente Diabet CAIPaDi, Mexico City, Mexico.
   [Lugo-Bautista, Karla; Mehta, Roopa] Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Endocrinol & Lipid Metab Dept, Mexico City, Mexico.
   [Martinez-Sanchez, Victor A.] Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Internal Med Dept, Mexico City, Mexico.
C3 Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran -
   Mexico; Instituto Nacional de Ciencias Medicas y Nutricion Salvador
   Zubiran - Mexico; Instituto Nacional de Ciencias Medicas y Nutricion
   Salvador Zubiran - Mexico
RP Hernández-Jiménez, S (corresponding author), Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Ctr Atenc Integral Paciente Diabet CAIPaDi, Mexico City, Mexico.
EM sergio.hernandezj@incmnsz.mx
FU Astra Zeneca; National Council of Science and Technology [214718];
   Medical Nutrition and Technology; Novo Nordisk; Eli Lilly; Silanes;
   Carlos Slim Health Institute
FX The CAIPaDi program has been generously funded by a variety of sources
   including Astra Zeneca, Fundacion Conde de Valenciana, Novartis, the
   National Council of Science and Technology (specifically the "Projects
   for Scientific Development to Address National Problems 2013 project
   214718") , Medical Nutrition and Technology, Novo Nordisk, Boehringer
   Ingelheim, the General Directorate of Quality and Health Education, Eli
   Lilly, Merck Serono, MSD, Silanes, Chinoin, and the Carlos Slim Health
   Institute. Apart from these sponsorships, there are no additional
   potential conflicts of interest relevant to this article.
CR Alvarenga L., 2002, Revista de Investigacion Clinica, V54, P403
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NR 34
TC 0
Z9 0
U1 0
U2 0
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-7007
J9 DIABET METAB SYND OB
JI Diabetes Metab. Syndr. Obes.
PY 2025
VL 18
BP 1539
EP 1549
DI 10.2147/DMSO.S483171
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 2OF5Q
UT WOS:001487347400001
PM 40365576
OA gold
DA 2025-06-11
ER

PT J
AU Yu, ZZ
   Niu, JP
   Wang, C
AF Yu, Zhenzhen
   Niu, Jianping
   Wang, Chen
TI The Prevalence and Risk Factors of Sexual Dysfunction in the Elderly in
   Southern China
SO INTERNATIONAL JOURNAL OF GENERAL MEDICINE
LA English
DT Article
DE epidemiology; sexual dysfunction; elderly; prevalence; risk factor
ID ERECTILE DYSFUNCTION; METABOLIC SYNDROME; TESTOSTERONE; ALCOHOL; MEN
AB Objective: This study aims to evaluate the epidemiological features of sexual dysfunction in people aged more than 65 years in parts of China, and to investigate the independent significant risk factors. Methods: According to the population distribution of five communities in Xiamen and Chongqing, we have randomly enrolled 2403 people more than 65 years-of-age. We collected data information through a questionnaire survey. Then demonstrated the current condition of sexual dysfunction in the samples by statistical analysis, and multivariable logistic regression was used to disclose the risk factors of sexual dysfunction in the older adults. Results: According to this study, about 10.48% of the elderly had sexual dysfunctions of different degrees and duration. The proportion of men was about twice that of women (14.5% of males and 7.3% of females). During the course of the disease, 3.19% (43/1344) of women and 3.31% (35/1059) of men had more than 15 years duration of sexual dysfunction. In severity, 5.7% (77/1344) of women and 7.0% (74/1059) of men had very severe sexual dysfunction. There were statistically significant differences in BMI, smoking, drinking history, hypertension, depression incidence or median (p<0.05). Alcohol consumption history [OR = 1.711, 95% CI: 1.124-2.604, p = 0.012] and depression [OR = 2.107, 95% CI: 1.109-4.356, p =0.044] were independent risk factors for sexual dysfunction. Conclusion: The prevalence of sexual dysfunction was low among elderly in the southern part of China. But the course of the disease is long and the degree of the disease is very severe. Elderly with a history of drinking and depression are more prone to sexual dysfunction.
C1 [Yu, Zhenzhen; Niu, Jianping] Xiamen Med Coll, Affiliated Hosp 2, Dept Neurol, Shengguang Rd 566, Xiamen 361000, Fujian, Peoples R China.
   [Wang, Chen] Xiamen Univ, Affiliated Hosp 1, Sch Med, Dept Neurol, Zhenhai Rd 55, Xiamen 361000, Fujian, Peoples R China.
   [Wang, Chen] Xiamen Univ, Affiliated Hosp 1, Sch Med, Dept Neurosci, Zhenhai Rd 55, Xiamen 361000, Fujian, Peoples R China.
C3 Xiamen Medical College; Xiamen University; Xiamen University
RP Niu, JP (corresponding author), Xiamen Med Coll, Affiliated Hosp 2, Dept Neurol, Shengguang Rd 566, Xiamen 361000, Fujian, Peoples R China.; Wang, C (corresponding author), Xiamen Univ, Affiliated Hosp 1, Sch Med, Dept Neurol, Zhenhai Rd 55, Xiamen 361000, Fujian, Peoples R China.; Wang, C (corresponding author), Xiamen Univ, Affiliated Hosp 1, Sch Med, Dept Neurosci, Zhenhai Rd 55, Xiamen 361000, Fujian, Peoples R China.
EM 549872685@qq.com; wangchen1986xm@163.com
FU Natural Science Fund of Xiamen [3502Z20224ZD1259]
FX This work was supported by the Natural Science Fund of Xiamen
   (3502Z20224ZD1259).
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NR 22
TC 2
Z9 2
U1 1
U2 6
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
EI 1178-7074
J9 INT J GEN MED
JI Int. J. Gen. Med.
PY 2024
VL 17
BP 2355
EP 2360
DI 10.2147/IJGM.S462124
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA RU1M7
UT WOS:001230081600001
PM 38803552
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Au, B
   Smith, KJ
   Gariépy, G
   Schmitz, N
AF Au, Bonnie
   Smith, Kimberley J.
   Gariepy, Genevieve
   Schmitz, Norbert
TI C-reactive protein, depressive symptoms, and risk of diabetes: Results
   from the English Longitudinal Study of Ageing (ELSA)
SO JOURNAL OF PSYCHOSOMATIC RESEARCH
LA English
DT Article
DE C-reactive protein; Depression; Diabetes; Longitudinal; Older adults
ID CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; BIDIRECTIONAL ASSOCIATION;
   PHYSICAL-ACTIVITY; OLDER-ADULTS; INFLAMMATION; HEALTH; METAANALYSIS;
   PREVALENCE; MELLITUS
AB Objectives: Raised levels of C-reactive protein (CRP), an inflammatory biomarker, and depressive symptoms are both independently linked to risk of diabetes. The purpose of this study was to assess the joint association of CRP and depressive symptomatology with diabetes incidence in a representative sample of English people >= 50 years old.
   Method: Data were from the English Longitudinal Study of Ageing, a prospective study of community-dwelling older adults. The sample was comprised of 4955 participants without self-reported doctor-diagnosed diabetes at baseline. High CRP level was dichotomized as >3 mg/L Elevated depressive symptomatology was defined as >= 4 using the 8-item Center for Epidemiologic Studies Depression Scale. Incident diabetes was determined based on newly self-reported doctor-diagnosed diabetes. Cox proportional hazard regressions were used to examine the association between CRP and depressive symptoms with incidence of type 2 diabetes.
   Results: During approximately 63.2 months of follow-up, 194 participants reported diabetes diagnosis. After adjustment for socio-demographics, lifestyle behaviors, clinical factors, and BMI, the hazard ratio for diabetes was 1.63 (95% Cl 0.88-3.01) for people with elevated depressive symptoms only, 1.43 (95% Cl 0.99-2.07) for people with high CRP only, and 2.03 (95% Cl 1.14-3.61) for people with both high CRP and elevated depressive symptoms.
   Conclusion: The presence of both high CRP levels and elevated depressive symptoms was associated with risk of diabetes. Further investigation into this relationship could aid in understanding the mechanisms underlying inflammation, depression, and diabetes. (C) 2014 Elsevier Inc. All rights reserved.
C1 [Au, Bonnie; Gariepy, Genevieve; Schmitz, Norbert] McGill Univ, Dept Epidemiol & Biostat, Montreal, PQ H3A 2T5, Canada.
   [Au, Bonnie; Smith, Kimberley J.; Gariepy, Genevieve; Schmitz, Norbert] Douglas Mental Hlth Univ Inst, Montreal, PQ H4H 1R3, Canada.
   [Smith, Kimberley J.; Schmitz, Norbert] McGill Univ, Dept Psychiat, Montreal, PQ H3A 2T5, Canada.
   [Schmitz, Norbert] Montreal Diabet Res Ctr, Montreal, PQ, Canada.
C3 McGill University; McGill University; Universite de Montreal
RP Au, B (corresponding author), Douglas Mental Hlth Univ Inst, 6875 Blvd LaSalle,FBC Pavil,Rm F-2116, Montreal, PQ H4H 1R3, Canada.
EM bonnie.au@mail.mcgill.ca
RI Schmitz, Norbert/AAH-3624-2020; Schmitz, Norbert/A-5177-2010
OI Schmitz, Norbert/0000-0001-7777-6323; Smith,
   Kimberley/0000-0002-1323-627X
FU Dr. Norbert Schmitz's Canadian Institutes of Health Research Operating
   [MOP 106514]
FX This study is supported by Dr. Norbert Schmitz's Canadian Institutes of
   Health Research Operating Grant MOP 106514 (Evaluation of diabetes
   treatment study).
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NR 63
TC 32
Z9 33
U1 2
U2 30
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-3999
EI 1879-1360
J9 J PSYCHOSOM RES
JI J. Psychosomat. Res.
PD SEP
PY 2014
VL 77
IS 3
BP 180
EP 186
DI 10.1016/j.jpsychores.2014.07.012
PG 7
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA AO2DU
UT WOS:000341126500004
PM 25128285
DA 2025-06-11
ER

PT J
AU McCabe, MP
   Sharlip, ID
   Lewis, R
   Atalla, E
   Balon, R
   Fisher, AD
   Laumann, E
   Lee, SW
   Segraves, RT
AF McCabe, Marita P.
   Sharlip, Ira D.
   Lewis, Ron
   Atalla, Elham
   Balon, Richard
   Fisher, Alessandra D.
   Laumann, Edward
   Lee, Sun Won
   Segraves, Robert T.
TI Risk Factors for Sexual Dysfunction Among Women and Men: A Consensus
   Statement From the Fourth International Consultation on Sexual Medicine
   2015
SO JOURNAL OF SEXUAL MEDICINE
LA English
DT Article
DE Risk Factors for Sexual Dysfunction; Men; Women; Biological Risk
   Factors; Psychological Risk Factors; Sociocultural Risk Factors
ID LOWER URINARY-TRACT; LIFE-STYLE CHANGES; NOCTURNAL PENILE TUMESCENCE;
   MALE ERECTILE DYSFUNCTION; CHRONIC-RENAL-FAILURE; QUALITY-OF-LIFE;
   METABOLIC SYNDROME; CARDIOVASCULAR-DISEASE; CIGARETTE-SMOKING;
   TESTOSTERONE DEFICIENCY
AB Introduction: This article presents a review of previous research concerning risk factors for sexual dysfunction in women and men.
   Aim: The aim is to evaluate past research studies to determine the contribution of all risk factors to the development and maintenance of sexual dysfunction among women and men.
   Methods: Studies were organized under a biopsychosocial framework, with the bulk of studies of women and men having investigated the role of biological factors.
   Main Outcome Measures: The outcome measures were the data on factors for sexual dysfunction.
   Results: Many more studies investigated risk factors for sexual dysfunction in men than in women. For women and men, diabetes, heart disease, urinary tract disorders, and chronic illness were significant risk factors for sexual dysfunction. Depression and anxiety and the medications used to treat these disorders also were risk factors for sexual dysfunction in women and men. In addition, substance abuse was associated with sexual dysfunction. Many other social and cultural factors were related to sexual dysfunction in women and men.
   Conclusion: Psychosocial factors are clearly risk factors for sexual dysfunction. Women and men with sexual dysfunction should be offered psychosocial evaluation and treatment, if available, in addition to medical evaluation and treatment. The impact of social and cultural factors on sexual function requires substantially more research. The evidence that erectile dysfunction is a harbinger of other forms of cardiovascular disease is strong enough to recommend that clinical evaluation for occult cardiovascular disease should be undertaken in men who do not have known cardiovascular disease but who develop organic erectile dysfunction, especially in men younger than 70 years. Copyright (C) 2016, International Society for Sexual Medicine. Published by Elsevier Inc. All rights reserved.
C1 [McCabe, Marita P.] Australian Catholic Univ, Inst Hlth & Ageing, Level 6,215 Spring St, Melbourne, Vic 3000, Australia.
   [Sharlip, Ira D.] Univ Calif San Francisco, San Francisco, CA 94143 USA.
   [Lewis, Ron] Georgia Regents Univ, Augusta, GA USA.
   [Atalla, Elham] RCSI Med Univ, Adilya, Bahrain.
   [Balon, Richard] Wayne State Univ, Dept Psychiat & Behav Neurosci, Detroit, MI 48207 USA.
   [Fisher, Alessandra D.] SODc Medicina Sessualita & Androl, Florence, Italy.
   [Laumann, Edward] Univ Chicago, Dept Sociol, Chicago, IL 60637 USA.
   [Lee, Sun Won] Sungkyunkwan Univ, Sch Med, Dept Urol, Seoul, South Korea.
   [Segraves, Robert T.] Case Western Reserve Univ, Cleveland, OH 44106 USA.
C3 Australian Catholic University; University of California System;
   University of California San Francisco; University System of Georgia;
   Augusta University; Royal College of Surgeons - Ireland; Royal College
   of Surgeons in Ireland - Medical University of Bahrain; Wayne State
   University; University of Chicago; Sungkyunkwan University (SKKU);
   University System of Ohio; Case Western Reserve University
RP McCabe, MP (corresponding author), Australian Catholic Univ, Inst Hlth & Ageing, Level 6,215 Spring St, Melbourne, Vic 3000, Australia.
EM Marita.McCabe@acu.edu.au
RI Fisher, Alessandra/AAC-3054-2019
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NR 189
TC 162
Z9 163
U1 1
U2 36
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1743-6095
EI 1743-6109
J9 J SEX MED
JI J. Sex. Med.
PD FEB
PY 2016
VL 13
IS 2
BP 153
EP 167
DI 10.1016/j.jsxm.2015.12.015
PG 15
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA DX9OX
UT WOS:000384726100003
PM 26953830
DA 2025-06-11
ER

PT J
AU Al-Foraih, M
   Somerset, S
AF Al-Foraih, Meisa
   Somerset, Shawn
TI Factors Affecting Adherence to Statins in Hypercholesterolemic Kuwaiti
   Patients: A Cross-Sectional Study
SO MEDICAL PRINCIPLES AND PRACTICE
LA English
DT Article
DE Statins; Adherence; Hypercholesterolemia
ID CORONARY-HEART-DISEASE; METABOLIC SYNDROME; DEPRESSION; PREVALENCE;
   MORBIDITY; MORTALITY; ANXIETY; SAMPLE; MODEL; MEN
AB Objective: This study examined statin adherence amongst Kuwaiti hypercholesterolemic patients in order to identify factors associated with poor adherence and to determine whether or not an association exists between statin adherence and the risk profile of coronary heart disease (CHD). Subjects and Methods: Two hundred hypercholesterolemic patients (30-69 years of age) were recruited from Kuwaiti primary healthcare clinics and interviewed about demographic characteristics, pre-existing self-reported medical conditions and prescribed medications. The Morisky Medication Adherence Scale was used to assess statin adherence (a self-reported, medication-adherence questionnaire divided into 3 levels, with a score of 8 denoting high adherence, 6 to < 8 denoting medium adherence and < 6 denoting low adherence). Data regarding anthropometric, psychological and serum risk factors were collected using 2 additional questionnaires, laboratory tests and bioelectrical impedance scales. Binary logistic regression was used to determine predictors of adherence and general linear modelling was used to test relationships between continuous outcomes and statin adherence. Results: Of the 200 participants, 117 (58.5%) reported low adherence, 83 (41.5%) reported medi-um adherence and no patients (0%) scored high adherence. Younger patients (aged 30-50 years) had lower adherence than older patients (> 50 years) [odds ratio (OR) 1.05; 95% confidence interval (CI) 1.01-1.09] for every extra year; p < 0.01). Those without diabetes, i. e. 113 (56.5%), were less likely to report medium adherence than those with diabetes (OR 0.42; 95% CI 0.23-0.75; p < 0.01). Low statin adherence was associated with higher levels of plasma cholesterol (p < 0.001) and low-density lipoprotein (p < 0.01). Conclusion: In this study, there was a high prevalence of low statin adherence, especially among younger patients with fewer concomitant diseases. The results indicated an inverse relationship between statin adherence and CHD risk profile. (C) 2016 S. Karger AG, Basel
C1 [Al-Foraih, Meisa] Publ Author Appl Educ & Training, Safat, Kuwait.
   [Somerset, Shawn] Australian Catholic Univ, Sch Allied Hlth, Brisbane, Qld, Australia.
C3 Public Authority for Applied Education & Training (PAAET) - Kuwait;
   Australian Catholic University
RP Somerset, S (corresponding author), Australian Catholic Univ, Sch Allied Hlth, POB 456, Virginia 4014, Australia.
EM Shawn.somerset@acu.edu.au
RI Alforaih, Meisa/LXB-5905-2024; Somerset, Shawn/K-4843-2014
OI Somerset, Shawn/0000-0002-4922-3593
CR Al Sifri SN, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0084350
   Al-Isa AN, 1997, ANN NUTR METAB, V41, P307, DOI 10.1159/000177959
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NR 29
TC 22
Z9 22
U1 0
U2 4
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1011-7571
EI 1423-0151
J9 MED PRIN PRACT
JI Med. Princ. Pract.
PY 2017
VL 26
IS 1
BP 35
EP 40
DI 10.1159/000450644
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA EH0MB
UT WOS:000391457100006
PM 27607329
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Kolkhir, P
   Bonnekoh, H
   Metz, M
   Maurer, M
AF Kolkhir, Pavel
   Bonnekoh, Hanna
   Metz, Martin
   Maurer, Marcus
TI Chronic Spontaneous Urticaria A Review
SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
LA English
DT Review
ID CHRONIC IDIOPATHIC URTICARIA; OMALIZUMAB TREATMENT; INDUCIBLE URTICARIA;
   ANGIOEDEMA; LIFE; ANTIHISTAMINES; COMORBIDITIES; METAANALYSIS;
   PREVALENCE; EFFICACY
AB Importance Chronic spontaneous urticaria affects approximately 1% of the general population worldwide, including approximately 3 million people in the US, impairs patients' quality of life, and is associated with multiple comorbidities. Observations Chronic spontaneous urticaria affects patients of any age but is most common in females aged 30 to 50 years. Diagnosis is based on clinical presentation, ie, spontaneously recurring wheals, angioedema, or both. Chronic spontaneous urticaria persists for more than 1 year in most patients (1 or repeated episodes) and may present with comorbidities including chronic inducible urticaria (>10%), autoimmune thyroiditis (approximately 20%), metabolic syndrome (6%-20%), and anxiety (10%-31%) and depression (7%-29%). Known autoimmune endotypes (subtypes of urticaria defined by distinct pathogenesis) of chronic spontaneous urticaria are mediated by mast cell-activating IgE and/or IgG autoantibodies (>50%). Approximately 40% of patients with chronic spontaneous urticaria have a Dermatology Life Quality Index of more than 10, corresponding to a very large or extremely large negative effect on quality of life. Second-generation H1 antihistamines are first-line treatment; partial or complete response, defined as a reduction in urticaria symptoms of greater than 50%, is observed in approximately 40% of patients. The 2022 international urticaria guideline recommends the monoclonal anti-IgE antibody omalizumab as second-line treatment for antihistamine-refractory chronic spontaneous urticaria. However, at least 30% of patients have an insufficient response to omalizumab, especially those with IgG-mediated autoimmune urticaria. Cyclosporine, used off-label, can improve symptoms in approximately 54% to 73% of patients, especially those with autoimmune chronic spontaneous urticaria and nonresponse to omalizumab, but has adverse effects such as kidney dysfunction and hypertension. Conclusions and Relevance Chronic spontaneous urticaria is an inflammatory skin disease associated with medical and psychiatric comorbidities and impaired quality of life. Second-generation H1 antihistamines are first-line treatment, omalizumab is second-line treatment, and cyclosporine is third-line treatment for chronic spontaneous urticaria.
C1 [Kolkhir, Pavel; Bonnekoh, Hanna; Metz, Martin; Maurer, Marcus] Charite Univ Med Berlin, Inst Allergol, Urticaria Ctr Reference & Excellence UCARE, Berlin, Germany.
   [Kolkhir, Pavel; Bonnekoh, Hanna; Metz, Martin; Maurer, Marcus] Free Univ Berlin, Berlin, Germany.
   [Kolkhir, Pavel; Bonnekoh, Hanna; Metz, Martin; Maurer, Marcus] Humboldt Univ, Berlin, Germany.
   [Kolkhir, Pavel; Bonnekoh, Hanna; Metz, Martin; Maurer, Marcus] Fraunhofer Inst Translat Med & Pharmacol ITMP, Immunol & Allergol, Berlin, Germany.
C3 Berlin Institute of Health; Free University of Berlin; Humboldt
   University of Berlin; Charite Universitatsmedizin Berlin; Free
   University of Berlin; Humboldt University of Berlin
RP Kolkhir, P (corresponding author), Charite Univ Med Berlin, Inst Allergol, Hindenburgdamm 30, D-12203 Berlin, Germany.
EM pavel.kolkhir@charite.de
RI Maurer, Marcus/ABG-2174-2020; Metz, Martin/B-8799-2009; Metz,
   Martin/M-5237-2013
OI Metz, Martin/0000-0002-4070-9976
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NR 94
TC 9
Z9 9
U1 6
U2 12
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 0098-7484
EI 1538-3598
J9 JAMA-J AM MED ASSOC
JI JAMA-J. Am. Med. Assoc.
PD NOV 5
PY 2024
VL 332
IS 17
BP 1464
EP 1477
DI 10.1001/jama.2024.15568
EA SEP 2024
PG 14
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA L4R4J
UT WOS:001321496000001
PM 39325444
DA 2025-06-11
ER

PT J
AU Dauden, E
   Blasco, AJ
   Bonanad, C
   Botella, R
   Carrascosa, JM
   González-Parra, E
   Jodar, E
   Joven, B
   Lázaro, P
   Olveira, A
   Quintero, J
   Rivera, R
AF Dauden, E.
   Blasco, A. J.
   Bonanad, C.
   Botella, R.
   Carrascosa, J. M.
   Gonzalez-Parra, E.
   Jodar, E.
   Joven, B.
   Lazaro, P.
   Olveira, A.
   Quintero, J.
   Rivera, R.
TI Position statement for the management of comorbidities in psoriasis
SO JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
LA English
DT Article
ID CAUSE-SPECIFIC MORTALITY; CHRONIC KIDNEY-DISEASE; FATTY LIVER-DISEASE;
   INCREASED RISK; MEDICAL COMORBIDITY; BLOOD-PRESSURE; ARTHRITIS;
   QUESTIONNAIRE; EPIDEMIOLOGY; SEVERITY
AB Background The association between psoriasis and some diseases has become relevant in recent years. Providing appropriate management of psoriasis from an early stage requires prompt diagnosis and treatment of concomitant diseases and to prevent any potential comorbidity. This approach should consider the adverse events of the drugs used to treat psoriasis potentially related to the onset of comorbidities. Objective Methods To provide the dermatologist with an accurate and friendly tool for systematizing the diagnosis of psoriasis-associated comorbidities, which generally escapes the scope of the dermatology setting, and to facilitate decision-making about the referral and treatment of patients with comorbidities. These position statement recommendations were developed by a working group composed of ten experts (four dermatologists, one cardiologist, one rheumatologist, one gastroenterologist, one nephrologist, one endocrinologist and one psychiatrist) and two health services researchers. The expert group selected the psoriasis comorbidities considered according to their relevance in the dermatology setting. The recommendations on diagnostic criteria are based on the current clinical practice guidelines for each of the comorbidities. The information regarding the repercussion of psoriasis medical treatments on associated comorbid diseases was obtained from the summary of product characteristics of each drug. Results Conclusion Recommendations were developed to detect and refer the following psoriasis comorbidities: psoriatic arthritis, cardiovascular risk factors (diabetes, dyslipidaemia, obesity, hypertension and metabolic syndrome), non-alcoholic fatty liver disease, inflammatory bowel disease, kidney disease and psychological disorders (anxiety and depression). In addition, alcohol consumption and tobacco consumption were included. The tables and figures are precise, easy-to-use tools to systematize the diagnosis of comorbidities in patients with psoriasis and facilitate the decision-making process regarding referral and treatment of patients with an associated disease. The application of these position statement recommendations will facilitate the dermatologist practice, and benefit psoriasis patients' health and quality of life.
C1 [Dauden, E.] Hosp Univ Princesa, Inst Invest Sanitaria Princesa IIS IP, Dept Dermatol, Madrid, Spain.
   [Blasco, A. J.; Lazaro, P.] Hlth Serv Res, Madrid, Spain.
   [Bonanad, C.] Hosp Clin Univ Valencia, Dept Cardiol, Valencia, Spain.
   [Botella, R.] Hosp Univ La Fe, Dept Dermatol, Valencia, Spain.
   [Carrascosa, J. M.] Univ Autonoma Barcelona, Hosp Univ Germans Trias & Pujol, Dept Dermatol, Badalona, Spain.
   [Gonzalez-Parra, E.] Fdn Jimenez Diaz, Dept Nephrol, Madrid, Spain.
   [Jodar, E.] Univ Europea Madrid, Hosp Univ Quiron Madrid & Ruber Juan Bravo, Dept Endocrinol & Clin Nutr, Madrid, Spain.
   [Joven, B.] Hosp Univ 12 Octubre, Dept Rheumatol, Madrid, Spain.
   [Olveira, A.] Hosp La Paz, Dept Gastroenterol & Hepatol, Madrid, Spain.
   [Quintero, J.] Hosp Infanta Leonor, Dept Psychiat, Madrid, Spain.
   [Rivera, R.] Hosp Univ 12 Octubre, Dept Dermatol, Madrid, Spain.
C3 Hospital de La Princesa; Hospital Clinic Universitari de Valencia;
   Hospital Universitari i Politecnic La Fe; Hospital Germans Trias i
   Pujol; Autonomous University of Barcelona; European University of
   Madrid; Hospital Universitario 12 de Octubre; Hospital Universitario La
   Paz; Hospital Universitario Infanta Leonor; Hospital Universitario 12 de
   Octubre
RP Lázaro, P (corresponding author), Hlth Serv Res, Madrid, Spain.
EM plazaro@gmx.es
RI Rivera Díaz, Raquel/HHN-1810-2022; Quintero, Javier/JUF-2417-2023
OI Rivera Diaz, Raquel/0000-0002-4604-0724; Quintero,
   Javier/0000-0002-2491-8647
FU Instituto de Salud Carlos III (Spanish Ministry of Economy, Industry and
   Competitiveness) [PI 14/01751, PI 17/01972]; Fundacion Investigacion
   Clinico-Dermatologica
FX This study was supported by Instituto de Salud Carlos III (Spanish
   Ministry of Economy, Industry and Competitiveness) PI 14/01751, PI
   17/01972 and 'Fundacion Investigacion Clinico-Dermatologica'.
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NR 65
TC 73
Z9 76
U1 0
U2 18
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0926-9959
EI 1468-3083
J9 J EUR ACAD DERMATOL
JI J. Eur. Acad. Dermatol. Venereol.
PD DEC
PY 2018
VL 32
IS 12
BP 2058
EP 2073
DI 10.1111/jdv.15177
PG 16
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA HC1PU
UT WOS:000451574100029
PM 29992631
DA 2025-06-11
ER

PT J
AU Ridder, LO
   Balle, CM
   Skakkebaek, A
   Lind-Holst, M
   Nielsen, MM
   Hermann, P
   Hansen, S
   Nielsen, DG
   Knorr, S
   Andersen, NH
   Viuff, MH
   Berglund, A
   Gravholt, CH
AF Ridder, Lukas Ochsner
   Balle, Camilla Mains
   Skakkebaek, Anne
   Lind-Holst, Marie
   Nielsen, Mette Molby
   Hermann, Pernille
   Hansen, Stinus
   Nielsen, Dorte Guldbrand
   Knorr, Sine
   Andersen, Niels Holmark
   Viuff, Mette Hansen
   Berglund, Agnethe
   Gravholt, Claus Hojbjerg
TI Endocrine, cardiac and neuropsychological aspects of adult congenital
   adrenal hyperplasia
SO CLINICAL ENDOCRINOLOGY
LA English
DT Article
DE cardiology; congenital adrenal hyperplasia; endocrinology;
   neuropsychology; quality of life
ID INSULIN-RESISTANCE; AUTISTIC TRAITS; ANDROGENS; CHILDREN; WOMEN;
   AGGRESSION; GIRLS
AB Objective: To investigate the metabolic, cardiovascular, and neuropsychological phenotype, quality of life (QoL), and hormonal regulation in individuals with congenital adrenal hyperplasia (CAH), a group of autosomal recessive disorders characterized by impaired synthesis of cortisol in the adrenal cortex and, if untreated compensatory hyperandrogenism. CAH is associated with an increased cardiovascular and metabolic morbidity, possibly due to overtreatment with glucocorticoids, leading to weight gain, insulin resistance, and metabolic syndrome. Design, Participants, Measurements: Thirty-seven individuals with CAH and 33 age- and sex-matched controls were evaluated at a single centre at Aarhus University Hospital with echocardiography, electrocardiogram, 24-h blood pressure, biochemistry, anthropometrics, and autism spectrum, anxiety, depression, personality, cognitive failures, and QoL were assessed using questionnaires. Results: CAH individuals had lower height than controls (170.5 vs. 182.9 cm in males and 160.2 vs. 170.1 cm in females, p < 0.01). Compared with female controls, females with CAH had higher haemoglobin (8.8 vs. 8.2 mmol/L, p = 0.003) and BMI (29.7 vs. 25.5 kg/m(2), p = 0.006), reduced insulin sensitivity (HOMA-IR): 2.7 vs. 1.9, p = 0.018), prolonged E-wave deceleration time (193 vs. 174 cm, p = 0.015), and E/e ratios (5.4 vs. 4.5, p = 0.017), and lower self-reported QoL. Males with CAH had more cognitive complaints (p = 0.034) and higher autistic scores (19.9 vs. 14.9; p = 0.068) compared with male controls. More individuals with CAH than controls reported writing problems. Conclusion: A sex-specific comorbidity profile is evident in CAH, with females presenting with decreased metabolic and overall self-reported health, whereas males with CAH presented with increased cognitive complaints and autistic traits.
C1 [Ridder, Lukas Ochsner; Balle, Camilla Mains; Knorr, Sine; Berglund, Agnethe; Gravholt, Claus Hojbjerg] Aarhus Univ Hosp, Dept Endocrinol, Palle Juul Jensen Blvd, DK-8200 Aarhus, Denmark.
   [Ridder, Lukas Ochsner; Skakkebaek, Anne; Lind-Holst, Marie; Viuff, Mette Hansen; Berglund, Agnethe; Gravholt, Claus Hojbjerg] Aarhus Univ Hosp, Dept Mol Med, Aarhus, Denmark.
   [Skakkebaek, Anne; Berglund, Agnethe] Aarhus Univ Hosp, Dept Clin Genet, Aarhus, Denmark.
   [Skakkebaek, Anne; Knorr, Sine; Viuff, Mette Hansen; Gravholt, Claus Hojbjerg] Aarhus Univ Hosp, Dept Clin Med, Aarhus, Denmark.
   [Nielsen, Mette Molby] Aarhus Univ Hosp, Dept Clin Biochem, Aarhus, Denmark.
   [Hermann, Pernille; Hansen, Stinus] Odense Univ Hosp, Dept Endocrinol, Odense, Denmark.
   [Nielsen, Dorte Guldbrand] Aarhus Univ Hosp, Dept Cardiol, Aarhus, Denmark.
   [Knorr, Sine] Aarhus Univ Hosp, Steno Diabet Ctr, Aarhus, Denmark.
   [Andersen, Niels Holmark] Aalborg Univ Hosp, Dept Cardiol, Aalborg, Denmark.
C3 Aarhus University; Aarhus University; Aarhus University; Aarhus
   University; Aarhus University; University of Southern Denmark; Odense
   University Hospital; Aarhus University; Steno Diabetes Center; Aarhus
   University; Aalborg University; Aalborg University Hospital
RP Ridder, LO (corresponding author), Aarhus Univ Hosp, Dept Endocrinol, Palle Juul Jensen Blvd, DK-8200 Aarhus, Denmark.
EM Lukrid@clin.au.dk
RI Skakkebæk, Anne/P-2345-2015; Gravholt, Claus/Z-1435-2018; Berglund,
   Agnethe/ABB-6991-2020; Viuff, Mette/AAH-1626-2021; Hansen,
   Stinus/F-8240-2016
OI Hansen, Stinus/0000-0001-9486-0316; Lind-Host,
   Marie/0000-0003-2585-8102; Andersen, Niels Holmark/0000-0002-5394-3016;
   Skakkebaek, Anne/0000-0001-9178-4901; Mains Balle,
   Camilla/0000-0001-7890-8201; Ridder, Lukas Ochsner/0000-0003-1110-748X;
   Nielsen, Mette Molby/0000-0001-6935-8287; Knorr,
   Sine/0000-0001-6552-5340; Berglund, Agnethe/0000-0001-9185-1342
FU Aase og Ejnar Danielsens Fond; Aase og Ejner Danielsens Fond
FX We express our gratitude to technicians Lone Kvist and Lisa Buus, for
   their valuable assistance in the project. We would also like to extend
   our thanks to Lotte H & oslash;rlyck, Bente Mortensen, as well as Donna
   Arbuckle-Lund, Anette Riis Madsen, Steffanie Anthony, Jeannet Foged
   Lindegaard, and Gitte Thomsen for their contributions. This project was
   funded by grants from Aase og Ejner Danielsens Fond.
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NR 38
TC 1
Z9 1
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0300-0664
EI 1365-2265
J9 CLIN ENDOCRINOL
JI Clin. Endocrinol.
PD JUN
PY 2024
VL 100
IS 6
BP 515
EP 526
DI 10.1111/cen.15055
EA APR 2024
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA PP6Q0
UT WOS:001196585700001
PM 38572909
OA hybrid
DA 2025-06-11
ER

PT J
AU Sun, Y
   Chen, JDDZ
AF Sun, Yan
   Chen, Jiande D. Z.
TI Rimonabant, Gastrointestinal Motility and Obesity
SO CURRENT NEUROPHARMACOLOGY
LA English
DT Article
DE Rimonabant; gastrointestinal motility; obesity; food intake
ID CANNABINOID CB1 RECEPTOR; CARDIOMETABOLIC RISK-FACTORS; GUINEA-PIG
   ILEUM; ENDOCANNABINOID SYSTEM; INTESTINAL MOTILITY; MYENTERIC PLEXUS;
   OVERWEIGHT PATIENTS; GASTRIC-MOTILITY; CIRCULAR MUSCLE; FOOD-INTAKE
AB Background: Obesity and overweight affect more than half of the US population and are associated with a number of diseases. Rimonabant, a cannabinoid receptor 1 blocker in the endocannabinoid (EC) system, was indicated in Europe for the treatment of obesity and overweight patients with associated risk factors but withdrawn on Jan, 2009 because of side effects. Many studies have reported the effects of rimonabant on gastrointestinal (GI) motility and food intake.
   The aims of this review are: (1) to review the relationship of EC system with GI motility and food intake; (2) to review the studies of rimonabant on GI motility, food intake and obesity; (3) and to report the tolerance and side effects of rimonabant.
   Methods: the literature (Pubmed database) was searched using keywords: rimonabant, obesity and GI motility.
   Results: GI motility is related with appetite, food intake and nutrients absorption. The EC system inhibits GI motility, reduces emesis and increases food intake; Rimonabant accelerates gastric emptying and intestinal transition but decreases energy metabolism and food intake. There is rapid onset of tolerance to the prokinetic effect of rimonabant. The main side effects of rimonabant are depression and GI symptoms.
   Conclusions: Rimonabant has significant effects on energy metabolism and food intake, probably mediated via its effects on GI motility.
C1 [Sun, Yan; Chen, Jiande D. Z.] VA Med Ctr, Vet Res & Educ Fdn, Oklahoma City, OK USA.
   [Chen, Jiande D. Z.] Texas Tech Univ, Hlth Sci Ctr, Dept Internal Med, Lubbock, TX 79409 USA.
C3 University of Oklahoma System; University of Oklahoma Health Sciences
   Center; Texas Tech University System; Texas Tech University Health
   Sciences Center Lubbock
RP Chen, JDDZ (corresponding author), Univ Texas Med Branch, GI Res 0655, Galveston, TX 77555 USA.
EM Jiande.Chen@utmb.edu
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NR 75
TC 14
Z9 15
U1 0
U2 11
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1570-159X
EI 1875-6190
J9 CURR NEUROPHARMACOL
JI Curr. Neuropharmacol.
PD SEP
PY 2012
VL 10
IS 3
BP 212
EP 218
DI 10.2174/157015912803217297
PG 7
WC Neurosciences; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pharmacology & Pharmacy
GA 016BF
UT WOS:000309491600003
PM 23449551
OA Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Matjuda, EN
   Engwa, GA
   Mungamba, MM
   Sewani-Rusike, CR
   Goswami, N
   Nkeh-Chungag, BN
AF Matjuda, Edna Ngoakoana
   Engwa, Godwill Azeh
   Mungamba, Muhulo Muhau
   Sewani-Rusike, Constance Rufaro
   Goswami, Nandu
   Nkeh-Chungag, Benedicta Ngwenchi
TI Cardio-Metabolic Health of Offspring Exposed in Utero to Human
   Immuno-Deficiency Virus and Anti-Retroviral Treatment: A Systematic
   Review
SO BIOLOGY-BASEL
LA English
DT Review
DE human immunodeficiency virus; antiretroviral therapy; in utero exposure;
   foetal environment; cardio-metabolic health; pregnancy; offspring
ID INFECTED PREGNANT-WOMEN; INTRAUTERINE GROWTH RESTRICTION; UNINFECTED
   CHILDREN; BIRTH-WEIGHT; MITOCHONDRIAL TOXICITY; CARDIOVASCULAR-DISEASE;
   PERINATAL OUTCOMES; DIASTOLIC FUNCTION; HIV-INFECTION; THERAPY
AB Simple Summary Although the use of antiretroviral treatment (ART) is effective in reducing the risk of HIV transmission to the foetus, there are concerns of possible adverse effects of in utero exposure on offspring's cardio-metabolic health. This paper systematically reviewed the effects of HIV/ART exposure during pregnancy on the cardio-metabolic health of offspring. Reports from 35 eligible studies showed that HIV-exposed uninfected (HEU) children's cardio-metabolic health was negatively impacted by in utero exposure to ART. A few studies showed direct cardiometabolic risk factors including increased blood pressure and lipids, reduced insulin, oxidative stress, cardiac damage and vascular and myocardial dysfunction among HEU children compared to their HIV-unexposed uninfected (HUU) children while most studies reported indirect cardiovascular risk factors including reduced head circumference, low birth weight, and altered mitochondrial content in HEU children. These findings suggest that in utero exposure of ART may affect foetal health predisposing them to cardiometabolic diseases later in life.Abstract Background: Antiretroviral treatment (ART) use during pregnancy continues to rise as it is known to decrease the likelihood of HIV transmission from mother to child. However, it is still unknown whether foetal exposure to (ART) may affect the foetal environment, predisposing the offspring to cardiometabolic risk. Therefore, the aim of this study was to systematically review the cardio-metabolic effects of in utero exposure to HIV/ART on offspring. Methods: We carried out a systematic review and obtained literature from the Google scholar, PubMed, ProQuest, Web of Science, and Scopus databases. Two independent reviewers evaluated the titles, abstracts, and full-length English contents. Data from the eligible studies were included. Results: The search yielded 7596 records. After assessing all of these records, 35 of the full-length articles were included in this systematic review. Several studies showed that low birth weight, small head circumference, and altered mitochondrial content were more common among HIV-exposed uninfected (HEU) children compared to HIV-unexposed uninfected children (HUU). A few studies demonstrated elevated triglyceride levels, lower levels of insulin, and increased blood pressure, oxidative stress, vascular dysfunction, cardiac damage, and myocardial dysfunction among HEU children compared with HUU children. Conclusion: Most findings showed that there were cardio-metabolic health risk factors among HEU children, indicating that maternal exposure to HIV and ART may negatively affect foetal health, which may lead to cardio-metabolic morbidity later in life.
C1 [Matjuda, Edna Ngoakoana; Mungamba, Muhulo Muhau; Sewani-Rusike, Constance Rufaro] Walter Sisulu Univ PBX1, Fac Hlth Sci, Dept Human Biol, ZA-5117 Mthatha, South Africa.
   [Engwa, Godwill Azeh; Goswami, Nandu; Nkeh-Chungag, Benedicta Ngwenchi] Walter Sisulu Univ PBX1, Fac Hlth Sci, Dept Biol & Environm Sci, ZA-5117 Mthatha, South Africa.
   [Goswami, Nandu] Med Univ Graz, Otto Loewi Res Ctr Vasc Biol Immunol & Inflammat, Physiol Div, Neue Stiftingtalstr 6,D-5A, A-8036 Graz, Austria.
   [Goswami, Nandu] Alma Mater Europaea, Dept Hlth Sci, Maribor 2000, Slovenia.
   [Goswami, Nandu] Mohammed Bin Rashid Univ Med & Hlth Sci, Coll Med, POB 505055, Dubai, U Arab Emirates.
C3 Medical University of Graz; Alma Mater Europaea
RP Nkeh-Chungag, BN (corresponding author), Walter Sisulu Univ PBX1, Fac Hlth Sci, Dept Biol & Environm Sci, ZA-5117 Mthatha, South Africa.
EM 217297331@mywsu.ac.za; gengwa@wsu.ac.za; mmungamba@wsu.ac.za;
   crusike@wsu.ac.za; nandu.goswami@medunigraz.at; bnkehchungag@wsu.ac.za
RI Goswami, Nandu/B-4021-2011; Chungag, Benedicta/AAU-8632-2021; Azeh
   Engwa, Godwill/T-1577-2017
OI Sewani-Rusike, Constance/0000-0002-3295-2933; Goswami,
   Nandu/0000-0002-6704-0723; Azeh Engwa, Godwill/0000-0002-0044-9890;
   Nkeh-Chungag, Benedicta Ngwenchi/0000-0003-4805-4051
FU South African National Research Foundation NRF-CPRR
FX No Statement Available
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NR 81
TC 1
Z9 1
U1 0
U2 8
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2079-7737
J9 BIOLOGY-BASEL
JI Biology-Basel
PD JAN
PY 2024
VL 13
IS 1
AR 32
DI 10.3390/biology13010032
PG 18
WC Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics
GA FW4X9
UT WOS:001148888900001
PM 38248463
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Gonzalez, DE
   Dickerson, BL
   Johnson, SE
   Woodruff, KE
   Leonard, M
   Yoo, C
   Ko, JB
   Xing, DT
   Martinez, V
   Kendra, J
   Estes, L
   Sowinski, RJ
   Rasmussen, CJ
   Martin, SE
   Kreider, RB
AF Gonzalez, Drew E.
   Dickerson, Broderick L.
   Johnson, Sarah E.
   Woodruff, Kathryn E.
   Leonard, Megan
   Yoo, Choongsung
   Ko, Joungbo
   Xing, Dante
   Martinez, Victoria
   Kendra, Jacob
   Estes, Landry
   Sowinski, Ryan J.
   Rasmussen, Chris J.
   Martin, Steven E.
   Kreider, Richard B.
TI Impact of astaxanthin supplementation on markers of cardiometabolic
   health and tactical performance among firefighters
SO JOURNAL OF THE INTERNATIONAL SOCIETY OF SPORTS NUTRITION
LA English
DT Article
DE Firefighting; oxidative stress; antioxidants; tactical athlete
ID OXIDATIVE STRESS; STATISTICAL SIGNIFICANCE; TIME; DISEASE; INFLAMMATION;
   OVERWEIGHT; EXERCISE; WORK
AB RationaleFirefighters are at risk for cardiovascular disease due to occupational-related inflammation, oxidative stress, and lifestyle practices. Astaxanthin (AX) possesses anti-inflammatory/antioxidant and purported ergogenic properties. This study examined the impact of supplementing the diet with 12 mg/d AX for four weeks on markers of inflammation, oxidative stress, cardiometabolic health, exercise capacity, and occupation-related performance in career firefighters.MethodsIn a randomized, double-blinded, placebo-controlled, crossover fashion, 15 male career firefighters (34.5 +/- 7.4 years; 177.7 +/- 7.0 cm; 95.6 +/- 12.0 kg; 30.1 +/- 2.9 kg/m2; 11.03 +/- 6.85 years of service) ingested 12 mg/d of AX (AstaReal (R), AstaReal AB, Nacka, SWE) or placebo (PLA) for four weeks while following a standardized resistance training program. After each treatment, testing sessions were completed to assess inflammatory markers, oxidative stress markers, cardiopulmonary exercise capacity, and performance to a fire ground test (FGT) consisting of nine fire suppressive activities. Data were analyzed using general linear model (GLM) analysis with repeated measures. Clinical significance was assessed via mean changes from baseline with 95% confidence intervals.ResultsAnalysis of mean percent changes from baseline revealed that AX supplementation lessened the inflammatory response to to performing an incremental maximal exercise test and attenuated increases in interleukin-1 beta, cortisol, and uric acid in response to performing fire suppressive activities compared to when they ingested PLA. However, most of these effects were within groups rather than between groups. Additionally, there was evidence that AX ingestion increased the ventilatory anaerobic threshold. Four weeks of AX supplementation did not significantly affect fasting markers of oxidative stress, blood lipids, performance during the FGT, general clinical chemistry panels, or self-reported side effects.ConclusionsResults provide some evidence that AX supplementation may help mediate occupation-related inflammation in response to high-intensity, short-duration exercise in firefighters. More research is warranted to determine if long-term supplementation can improve cardiometabolic risk in this population.Clinical trial registrationISRCTN10901752.
C1 [Gonzalez, Drew E.; Dickerson, Broderick L.; Johnson, Sarah E.; Woodruff, Kathryn E.; Leonard, Megan; Yoo, Choongsung; Ko, Joungbo; Xing, Dante; Martinez, Victoria; Kendra, Jacob; Estes, Landry; Sowinski, Ryan J.; Rasmussen, Chris J.; Kreider, Richard B.] Texas A&M Univ, Dept Kinesiol & Sport Management, Exercise & Sport Nutr Lab, College Stn, TX 77843 USA.
   [Martin, Steven E.] Texas A&M Univ, Sydney & JL Huffines Inst Sports Med & Human Perfo, Dept Kinesiol & Sport Management, College Stn, TX USA.
C3 Texas A&M University System; Texas A&M University College Station; Texas
   A&M University System; Texas A&M University College Station
RP Kreider, RB (corresponding author), Texas A&M Univ, Dept Kinesiol & Sport Management, Exercise & Sport Nutr Lab, College Stn, TX 77843 USA.
EM rbkreider@tamu.edu
RI Kreider, Richard/AEE-5745-2022
OI Yoo, Choongsung/0000-0002-1112-336X; Gonzalez, Andrew
   Edward/0000-0002-7279-4968
FU AstaReal(R) (Burlington, NJ, USA) [2201149]; Exercise and Sport
   Nutrition Laboratory
FX This study was funded as a doctoral student research grant by AstaReal
   (R) (Burlington, NJ, USA) to Dr. Kreider and the Exercise and Sport
   Nutrition Laboratory. The funding agency was not involved in the data
   collection, analysis, interpretation, or preparation of this paper.
   AstaReal (R) (Burlington, NJ, USA) [2201149].
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NR 81
TC 0
Z9 0
U1 3
U2 4
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
EI 1550-2783
J9 J INT SOC SPORT NUTR
JI J. Int. Soc. Sport Nutr.
PD DEC 31
PY 2024
VL 21
IS 1
AR 2427751
DI 10.1080/15502783.2024.2427751
PG 27
WC Nutrition & Dietetics; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics; Sport Sciences
GA M8Z5W
UT WOS:001360362000001
PM 39568140
OA gold
DA 2025-06-11
ER

PT J
AU Amine, I
   Guillien, A
   Philippat, C
   Anguita-Ruiz, A
   Casas, M
   de Castro, M
   Dedele, A
   Garcia-Aymerich, J
   Granum, B
   Grazuleviciene, R
   Heude, B
   Haug, LS
   Julvez, J
   López-Vicente, M
   Maitre, L
   McEachan, R
   Nieuwenhuijsen, M
   Stratakis, N
   Vafeiadi, M
   Wright, J
   Yang, TFY
   Yuan, WL
   Basagana, X
   Slama, R
   Vrijheid, M
   Siroux, V
AF Amine, Ines
   Guillien, Alicia
   Philippat, Claire
   Anguita-Ruiz, Augusto
   Casas, Maribel
   de Castro, Montserrat
   Dedele, Audrius
   Garcia-Aymerich, Judith
   Granum, Berit
   Grazuleviciene, Regina
   Heude, Barbara
   Haug, Line Smastuen
   Julvez, Jordi
   Lopez-Vicente, Monica
   Maitre, Lea
   McEachan, Rosemary
   Nieuwenhuijsen, Mark
   Stratakis, Nikos
   Vafeiadi, Marina
   Wright, John
   Yang, Tiffany
   Yuan, Wen Lun
   Basagana, Xavier
   Slama, Remy
   Vrijheid, Martine
   Siroux, Valerie
TI Environmental exposures in early-life and general health in childhood
SO ENVIRONMENTAL HEALTH
LA English
DT Article
DE Environment; Exposome; Cohort studies; Cardiometabolic risk factors;
   Neurodevelopment; Respiratory diseases; Pregnancy; Child;
   Multimorbidity; General health status
ID COHORT PROFILE; PHYSICAL-ACTIVITY; ASTHMA; RISK; SENSITIZATION;
   EXPOSOME; MOTHER; RATIONALE; SELECTION; UPDATE
AB BackgroundEarly-life environmental exposures are suspected to be involved in the development of chronic diseases later in life. Most studies conducted so far considered single or few exposures and single-health parameter. Our study aimed to identify a childhood general health score and assess its association with a wide range of pre- and post-natal environmental exposures.MethodsThe analysis is based on 870 children (6-12 years) from six European birth cohorts participating in the Human Early-Life Exposome project. A total of 53 prenatal and 105 childhood environmental factors were considered, including lifestyle, social, urban and chemical exposures. We built a general health score by averaging three sub-scores (cardiometabolic, respiratory/allergy and mental) built from 15 health parameters. By construct, a child with a low score has a low general health status. Penalized multivariable regression through Least Absolute Shrinkage and Selection Operator (LASSO) was fitted in order to identify exposures associated with the general health score.FindingsThe results of LASSO show that a lower general health score was associated with maternal passive and active smoking during pregnancy and postnatal exposure to methylparaben, copper, indoor air pollutants, high intake of caffeinated drinks and few contacts with friends and family. Higher child's general health score was associated with prenatal exposure to a bluespace near residency and postnatal exposures to pets, cobalt, high intakes of vegetables and more physical activity. Against our hypotheses, postnatal exposure to organochlorine compounds and perfluorooctanoate were associated with a higher child's general health score.ConclusionBy using a general health score summarizing the child cardiometabolic, respiratory/allergy and mental health, this study reinforced previously suspected environmental factors associated with various child health parameters (e.g. tobacco, air pollutants) and identified new factors (e.g. pets, bluespace) warranting further investigations.
C1 [Amine, Ines; Guillien, Alicia; Philippat, Claire; Slama, Remy; Siroux, Valerie] Univ Grenoble Alpes, Inst Adv Biosci, Team Environm Epidemiol Appl Dev & Resp Hlth, Inserm,U 1209,INRS,UMR 5309, Grenoble, France.
   [Anguita-Ruiz, Augusto; Casas, Maribel; de Castro, Montserrat; Garcia-Aymerich, Judith; Julvez, Jordi; Lopez-Vicente, Monica; Maitre, Lea; Nieuwenhuijsen, Mark; Stratakis, Nikos; Basagana, Xavier; Vrijheid, Martine] ISGlobal Inst Salud Global Barcelona Campus MAR, Parc Recerca Biomed Barcelona PRBB, Barcelona 08003, Spain.
   [Anguita-Ruiz, Augusto] Inst Hlth Carlos III ISCIII, CIBEROBN, Physiopathol Obes & Nutr CB12 03 30038, Madrid 28029, Spain.
   [Casas, Maribel; de Castro, Montserrat; Garcia-Aymerich, Judith; Maitre, Lea; Nieuwenhuijsen, Mark; Basagana, Xavier; Vrijheid, Martine] Pompeu Fabra Univ UPF, Barcelona 08002, Spain.
   [Casas, Maribel; de Castro, Montserrat; Garcia-Aymerich, Judith; Maitre, Lea; Nieuwenhuijsen, Mark; Basagana, Xavier; Vrijheid, Martine] Spanish Consortium Res Epidemiol & Publ Hlth CIBER, Av Monforte Lemos 3-5,Pabellon 11, Madrid 28029, Spain.
   [de Castro, Montserrat] FISABIO Univ Jaume I Univ Valencia, Fdn Promot Hlth & Biomed Res Valencian Reg, Epidemiol & Environm Hlth Joint Res Unit, FISABIO Publ Hlth, Av Catalunya 21, Valencia 46020, Spain.
   [Dedele, Audrius; Grazuleviciene, Regina] Vytautas Magnus Univ, Dept Environm Sci, LT-44248 Kaunas, Lithuania.
   [Granum, Berit; Haug, Line Smastuen] Norwegian Inst Publ Hlth, Div Climate & Environm Hlth, N-0213 Oslo, Norway.
   [Heude, Barbara; Yuan, Wen Lun] Univ Paris Cite, F-75004 Paris, France.
   [Heude, Barbara; Yuan, Wen Lun] Univ Sorbonne Paris Nord, Ctr Res Epidemiol & Stat CRESS, Inserm, INRAE, F-75004 Paris, France.
   [Julvez, Jordi] Inst Invest Sanitaria Pere Virgili IISPV, Clin & Epidemiol Neurosci NeuroEpia, Reus 43204, Spain.
   [McEachan, Rosemary; Wright, John; Yang, Tiffany] Bradford Teaching Hosp NHS Fdn Trust, Bradford Inst Hlth Res, Bradford, England.
   [Vafeiadi, Marina] Univ Crete, Sch Med, Dept Social Med, Iraklion, Greece.
   [Yuan, Wen Lun] ASTAR, Singapore Inst Clin Sci, Singapore, Singapore.
C3 Communaute Universite Grenoble Alpes; Universite Grenoble Alpes (UGA);
   Institut National de la Sante et de la Recherche Medicale (Inserm);
   Centre National de la Recherche Scientifique (CNRS); CNRS - National
   Institute for Biology (INSB); Pompeu Fabra University; Barcelona
   Biomedical Research Park; CIBER - Centro de Investigacion Biomedica en
   Red; CIBEROBN; Pompeu Fabra University; Universitat Jaume I; Vytautas
   Magnus University; Norwegian Institute of Public Health (NIPH);
   Universite Paris Cite; INRAE; Institut National de la Sante et de la
   Recherche Medicale (Inserm); Universite Paris Cite; Universitat Rovira i
   Virgili; Institut d'Investigacio Sanitaria Pere Virgili (IISPV);
   University of Crete; Agency for Science Technology & Research (A*STAR);
   A*STAR - Singapore Institute for Clinical Sciences (SICS)
RP Amine, I (corresponding author), Univ Grenoble Alpes, Inst Adv Biosci, Team Environm Epidemiol Appl Dev & Resp Hlth, Inserm,U 1209,INRS,UMR 5309, Grenoble, France.
EM ines.amine@univ-grenoble-alpes.fr
RI Dedele, Audrius/NJR-2946-2025; Anguita-Ruiz, Augusto/AAE-9827-2019;
   Guillien, Alicia/T-5982-2019; McEachan, Rosemary/NJR-9941-2025;
   Grazuleviciene, Regina/AAR-4539-2021; de Castro,
   Montserrat/ABF-8902-2020; Maitre, Léa/Y-1726-2019; Vafeiadi,
   Marina/I-8387-2019; Heude, Barbara/G-3095-2016; Basagaña,
   Xavier/C-3901-2017; Granum, Berit/AAA-7823-2022; Stratakis,
   Nikos/AFV-3674-2022; Yuan, Wen Lun/ABC-4795-2021; J,
   Garcia-Aymerich/G-6867-2014; Philippat, Claire/N-2423-2013; Casas,
   Maribel/T-5643-2017; Vrijheid, Martine/H-2702-2014; Julvez,
   Jordi/R-4531-2017; Wright, John/H-1624-2012; SIROUX,
   Valerie/N-1865-2013; YUAN, Wen Lun/J-1137-2014
OI Guillien, Alicia/0000-0003-0586-3449; Haug, Line
   Smastuen/0000-0001-6746-6399; Stratakis, Nikolaos
   (Nikos)/0000-0003-4613-0989; Vrijheid, Martine/0000-0002-7090-1758;
   Amine, Ines/0000-0003-1213-499X; Julvez, Jordi/0000-0003-0818-4003;
   Wright, John/0000-0001-9572-7293; SIROUX, Valerie/0000-0001-7329-7237;
   McEachan, Rosemary/0000-0003-1302-6675; YUAN, Wen
   Lun/0000-0002-7472-5042; Yang, Tiffany C/0000-0003-4549-7850
FU Spanish Ministry of Science and Innovation [2018-000806-S]; Generalitat
   de Catalunya through the Centres de Recerca de Catalunya (CERCA) Program
FX We are grateful to all the participating families, practitioners,
   schools and researchers in France, Greece, Lithuania, Spain, Norway and
   UK who made this study happen. This project is only possible because of
   their enthusiasm and commitment. Additionnaly, ISGlobal acknowledges
   support from the "Centro de Excelencia Severo Ochoa 2019-2023" Program
   2018-000806-S from the Spanish Ministry of Science and Innovation, and
   from the Generalitat de Catalunya through the Centres de Recerca de
   Catalunya (CERCA) Program.
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NR 53
TC 13
Z9 13
U1 1
U2 15
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1476-069X
J9 ENVIRON HEALTH-GLOB
JI Environ. Health
PD JUL 21
PY 2023
VL 22
IS 1
AR 53
DI 10.1186/s12940-023-01001-x
PG 14
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA N1AQ2
UT WOS:001034428700001
PM 37480033
OA gold, Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Wentzel, A
   Smith, W
   van Vuren, EJ
   Kruger, R
   Breet, Y
   Wonkam-Tingang, E
   Hanchard, NA
   Chung, ST
AF Wentzel, A.
   Smith, W.
   van Vuren, E. Jansen
   Kruger, R.
   Breet, Y.
   Wonkam-Tingang, E.
   Hanchard, N. A.
   Chung, S. T.
TI Allostatic load and cardiometabolic health in a young adult South
   African population: the African-PREDICT study
SO AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
LA English
DT Article
DE allostasis; cardiometabolic health; neurological age; South Africa;
   stress
ID STRESS; RISK; REACTIVITY; MARKER; LINK
AB Sustained stress, assessed as a high allostatic load score (ALS), is an independent cardiovascular disease (CVD) risk factor in older adults but its associations in young people are undefined. Since neurological maturation impacts stress adaptation and CVD risk, we assessed the relationship of ALS with CVD profile by using a tiered approach stratified by age [emerging adults (EA) aged 20-24 yr vs. young adults (YA) aged 25-30 yr] and ALS (high vs. low). In 1,054 healthy participants of the African Prospective Study on Early Detection and Identification of Cardiovascular Disease and Hypertension (African-PREDICT), we determined: 1) ALS in EA versus YA; 2) the relationship between ALS and cardiovascular (CV) health, and 3) the odds of high ALS > 4 to identify masked hypertension (HT) and prediabetes as cardiometabolic outcomes. A nine-component, four-domain ALS was compiled: neuroendocrine [dehydroepiandrosterone (DHEA), cortisol], inflammatory [interleukin-6 (IL-6), C-reactive protein (CRP)], cardiovascular [systolic blood pressure (SBP) and diastolic blood pressure (DBP)], and metabolic [total cholesterol, high density lipoprotein cholesterol (HDL-cholesterol), body mass index (BMI)]. Retinal vessel caliber, pulse wave velocity (PWV), and cardiac structure and function were assessed. Median ALS was 3 (range: 1-9). A high-ALS > 4 was more common in YA versus EA (47 vs. 35%, P = 0.032). Higher ALS associated with narrower retinal arteries (P < 0.01), greater PWV (P <= 0.01), lower diastolic function (P < 0.01), and left ventricular (LV) function (P < 0.01). High-ALS increased the odds of having masked hypertension, prediabetes, narrower retinal arteries, higher LV mass, poorer diastolic and ventricular functions (all P <= 0.01), in EA and YA independent of traditional CVD risk factors. The composite ALS identified early-stress dysregulation in cardiometabolic health and higher odds for masked hypertension and prediabetes in young adults. Cumulative stress may be a modifiable, independent cardiometabolic risk factor in younger populations that needs further investigation.
C1 [Wentzel, A.; Smith, W.; van Vuren, E. Jansen; Kruger, R.; Breet, Y.] North West Univ, Hypertens Africa Res Team, Potchefstroom, South Africa.
   [Wentzel, A.; Smith, W.; van Vuren, E. Jansen; Kruger, R.; Breet, Y.] North West Univ, South African Med Res Council, Unit Hypertens & Cardiovasc Dis, Potchefstroom, South Africa.
   [Wonkam-Tingang, E.; Hanchard, N. A.] NHGRI, Childhood Complex Dis Genom Sect, Ctr Precis Hlth Res, NIH, Bethesda, MD USA.
   [Chung, S. T.] NIDDK, Sect Pediat Diabet Endocrinol & Metab, Diabet Endocrinol & Obes Branch, NIH, Bethesda, MD USA.
C3 North West University - South Africa; South African Medical Research
   Council; North West University - South Africa; National Institutes of
   Health (NIH) - USA; NIH National Human Genome Research Institute
   (NHGRI); National Institutes of Health (NIH) - USA; NIH National
   Institute of Diabetes & Digestive & Kidney Diseases (NIDDK)
RP Wentzel, A (corresponding author), North West Univ, Hypertens Africa Res Team, Potchefstroom, South Africa.; Wentzel, A (corresponding author), North West Univ, South African Med Res Council, Unit Hypertens & Cardiovasc Dis, Potchefstroom, South Africa.
EM Annemarie.Wentzel@nwu.ac.za
RI Jansen van Vuren, Esmé/AAE-7828-2022; Breet, Yolandi/AGY-9164-2022;
   Kruger, Ruan/N-7618-2015
OI Kruger, Ruan/0000-0001-7680-2032; Jansen van Vuren,
   Esme/0000-0002-0307-4537; Hanchard, Neil/0000-0003-1925-2665
FU North-West University (NWU); South African Medical Research Council
   (SAMRC); South African Research Chairs Initiative (SARChI) under the
   Department of Science and Technology [GUN 86895]; National Research
   Foundation (NRF) of South Africa; South African National Department of
   Health; UK Medical Research Council; UK Government's Newton Fund; Pfizer
   (South Africa); Boehringer-Ingelheim (South Africa); Novartis (South
   Africa)
FX The authors acknowledge the important contribution made by the
   participants of the African-PREDICT study, as well as the significant
   contributions of all Hypertension in Africa Research Team (HART) and
   North-West University (NWU) staff as well as students at HART. As the
   African-PREDICT is an ongoing project under HART, NWU, the authors
   acknowledge the financial support of the South African Medical Research
   Council (SAMRC), the South African Research Chairs Initiative (SARChI)
   under the Department of Science and Technology, and the National
   Research Foundation (NRF) of South Africa (GUN 86895). We also express
   sincere gratitude to the support provided by the South African National
   Department of Health, GlaxoSmithKline R&D (Africa Non-Communicable
   Disease Open Lab Grant), and the UK Medical Research Council, which is
   supported by the UK Government's Newton Fund. African-PREDICT has also
   been awarded corporate social investment grants from Pfizer (South
   Africa), Boehringer-Ingelheim (South Africa), Novartis (South Africa),
   and in-kind contributions from Roche Diagnostics (South Africa).
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NR 51
TC 0
Z9 0
U1 3
U2 3
PU AMER PHYSIOLOGICAL SOC
PI Rockville
PA 6120 Executive Blvd, Suite 600, Rockville, MD, UNITED STATES
SN 0363-6135
EI 1522-1539
J9 AM J PHYSIOL-HEART C
JI Am. J. Physiol.-Heart Circul. Physiol.
PD MAR 7
PY 2025
VL 328
IS 3
BP H581
EP H593
DI 10.1152/ajpheart.00845.2024
PG 13
WC Cardiac & Cardiovascular Systems; Physiology; Peripheral Vascular
   Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Physiology
GA 0PE1J
UT WOS:001452702400002
PM 39918735
DA 2025-06-11
ER

PT J
AU Almog, R
   Carasso, S
   Lavi, I
   Amir, O
AF Almog, Ronit
   Carasso, Shemy
   Lavi, Idit
   Amir, Offer
TI The risk for a first acute coronary syndrome in patients treated with
   different types of antidepressants: A population based nested
   case-control study
SO INTERNATIONAL JOURNAL OF CARDIOLOGY
LA English
DT Article
DE Antidepressants; Acute coronary syndrome
ID SEROTONIN REUPTAKE INHIBITORS; ACUTE MYOCARDIAL-INFARCTION; MAJOR
   DEPRESSIVE DISORDER; CARDIOVASCULAR-DISEASE; HEART-DISEASE; MORTALITY;
   MORBIDITY; EVENTS
AB Background: Tricyclic antidepressants (TCAs) are still used in 30% of anxiety/depression cases and have been related to increased cardiovascular risk. Newer serotonin/norepinephrine reuptake inhibitors (SSRIs/SNRIs) safety remains conflicting. Our aimwas to assess the risk of a first acute coronary syndrome (ACS) in patients treated by various types of antidepressants.
   Methods: Study was a retrospective nested case-control of 40-80 years old northern-Israeli members of Clalit Health Services (CHS) during 1.1.2003-31.12.2013. Patients with severe psychiatric, cardiac or systemic diseases, or pre-enrollment antidepressants were excluded. Cases that had a first ACS during the study period were matched in 1: 30 ratio with controls. The association between antidepressants use and ACS was tested by adjusted multivariable conditional logistic regression.
   Results: The cohort included 535,315 individuals 128,550 of whom met the exclusion/inclusion criteria. 3391 Cases with first ACS, (incidence rate of 24.6/10,000 person years) were matched with 88,016 controls. ACS was not associated with use of either SSRIS/SNRIS or TCAs compared with no antidepressants use. However, treatment by SSRIS/SNRIS was associated with a 36% decreased risk ACS compared to TCAs, OR = 0. 64, 95% CI (0.43-0.95), p = 0.029. Age 40-64 years, male gender and metabolic syndrome associated with reduced risk of ACS among SSRIS/SNRIS compared to TCAs users.
   Conclusion: In this study of patients without prior cardiovascular disease-neither antidepressant group imposed excess risk for ACS, compared to-no treatment. SSRIs treatment seemed safer compared to TCAs in regard of ACS. This study probably adds to our confidence of preferring SSRIs over TCAs in patients without prior cardiovascular disease. (C) 2018 Elsevier B.V. All rights reserved.
C1 [Almog, Ronit] Rambam Hlth Care Ctr, Epidemiol Unit, Haifa, Israel.
   [Almog, Ronit; Lavi, Idit] Univ Haifa, Sch Publ Hlth, Fac Social Welf & Hlth Sci, Haifa, Israel.
   [Lavi, Idit] Carmel Med Ctr Haifa, Dept Community Med & Epidemiol, Haifa, Israel.
   [Carasso, Shemy; Amir, Offer] B Padeh Med Ctr, Cardiovasc Div, IL-15208 Poriya, Lower Galilee, Israel.
   [Carasso, Shemy; Amir, Offer] Bar Ilan Univ, Fac Med Galilee, IL-1311502 Safed, Israel.
C3 Rambam Health Care Campus; University of Haifa; Clalit Health Services;
   Carmel Medical Center; Bar Ilan University
RP Carasso, S (corresponding author), B Padeh Med Ctr, Div Cardiovasc Med, IL-15208 Poriya, Lower Galilee, Israel.
EM oamir@poria.health.gov.il
RI Carasso, Shemy/ABE-3898-2020
OI Carasso, Shemy/0000-0002-9582-770X
CR Alvarez W, 2003, PHARMACOTHERAPY, V23, P754, DOI 10.1592/phco.23.6.754.32185
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NR 31
TC 2
Z9 3
U1 3
U2 11
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0167-5273
EI 1874-1754
J9 INT J CARDIOL
JI Int. J. Cardiol.
PD SEP 15
PY 2018
VL 267
BP 28
EP 34
DI 10.1016/j.ijcard.2018.04.137
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA GK9LJ
UT WOS:000436570700006
PM 29957260
DA 2025-06-11
ER

PT J
AU Chen, CH
   Lin, CL
   Kao, CH
AF Chen, Chien-Hua
   Lin, Cheng-Li
   Kao, Chia-Hung
TI Association between gastroesophageal reflux disease and coronary heart
   disease A nationwide population-based analysis
SO MEDICINE
LA English
DT Article
DE cohort; comorbidity; coronary heart disease; gastroesophageal reflux
   disease
ID METABOLIC SYNDROME; RISK-FACTORS; MYOCARDIAL-INFARCTION; ARTERY-DISEASE;
   ESOPHAGITIS; PREVALENCE; OBESITY; EPIDEMIOLOGY; METAANALYSIS; SYMPTOMS
AB In this study, we aimed to determine the association between gastroesophageal reflux disease (GERD) and subsequent coronary heart disease (CHD) development, if any, and to evaluate whether longer use of proton pump inhibitors (PPIs) increases the risk of CHD.
   Patients diagnosed with GERD between 2000 and 2011 were identified as the study cohort (n=12,960). Patients without GERD were randomly selected from the general population, frequency-matched with the study group according to age, sex, and index year, and evaluated as the comparison cohort (n=51,840). Both cohorts were followed up until the end of 2011 to determine the incidence of CHD. The risk of CHD was evaluated in both groups by using Cox proportional hazards regression models.
   The GERD patients had a greater probability of CHD than the cohort without GERD did (log-rank test, P<0.001 and 11.8 vs 6.5 per 1000 person-years). The GERD cohort had a higher risk of CHD than the comparison cohort did after adjustment for age, sex, hypertension, diabetes, hyperlipidemia, alcohol-related illness, stroke, chronic obstructive pulmonary disease, asthma, biliary stone, anxiety, depression, chronic kidney disease, and cirrhosis (adjusted hazard ratio [aHR]: 1.49, 95% confidence interval [CI]: 1.34-1.66). The risk of CHD was greater for the patients treated with PPIs for more than 1 year (aHR=1.67, 95% CI=1.34-2.08) than for those treated with PPIs for <1 year (aHR=1.56, 95% CI=1.39-1.74).
   Our population-based cohort study results indicate that GERD was associated with an increased risk of developing CHD, and that PPI use for more than 1 year might increase the risk of CHD.
C1 [Chen, Chien-Hua] Show Chwan Mem Hosp, Digest Dis Ctr, Changhua, Taiwan.
   [Chen, Chien-Hua] Hungkuang Univ, Dept Food Sci & Technol, Taichung, Taiwan.
   [Chen, Chien-Hua] Chung Chou Univ Sci & Technol, Yuanun Township, Changhua County, Taiwan.
   [Lin, Cheng-Li] China Med Univ Hosp, Management Off Hlth Data, Taichung, Taiwan.
   [Lin, Cheng-Li] China Med Univ, Coll Med, Taichung, Taiwan.
   [Kao, Chia-Hung] China Med Univ, Coll Med, Grad Inst Clin Med Sci, 2 Yuh Der Rd, Taichung 40447, Taiwan.
   [Kao, Chia-Hung] China Med Univ, Coll Med, Sch Med, 2 Yuh Der Rd, Taichung 40447, Taiwan.
   [Kao, Chia-Hung] China Med Univ Hosp, Dept Nucl Med, Taichung, Taiwan.
   [Kao, Chia-Hung] China Med Univ Hosp, PET Ctr, Taichung, Taiwan.
C3 Show Chwan Memorial Hospital; Hungkuang University; China Medical
   University Taiwan; China Medical University Hospital - Taiwan; China
   Medical University Taiwan; China Medical University Taiwan; China
   Medical University Taiwan; China Medical University Taiwan; China
   Medical University Hospital - Taiwan; China Medical University Taiwan;
   China Medical University Hospital - Taiwan
RP Kao, CH (corresponding author), China Med Univ, Coll Med, Grad Inst Clin Med Sci, 2 Yuh Der Rd, Taichung 40447, Taiwan.; Kao, CH (corresponding author), China Med Univ, Coll Med, Sch Med, 2 Yuh Der Rd, Taichung 40447, Taiwan.
EM d10040@mail.cmuh.org.tw
RI Chen, Duke/JGD-9727-2023; Liao, Yu-Chi/AAT-1357-2021
OI Lin, Cheng-Li/0000-0001-9926-3668
FU Taiwan Ministry of Health and Welfare Clinical Trial and Research Center
   of Excellence [MOHW105-TDU-B-212-133019]; China Medical University
   Hospital (CMU); Academia Sinica Taiwan Biobank Stroke Biosignature
   Project [BM10501010037]; NRPB Stroke Clinical Thai Consortium [MOST
   104-2325-B-039-005]; Tseng-Lien Lin Foundation, Taichung, Taiwan; Taiwan
   Brain Disease Foundation, Taipei, Taiwan; Katsuzo and Kiyo Aoshima
   Memorial Funds, Japan; CMU under the Aim for Top University Plan of the
   Ministry of Education, Taiwan
FX This study ens supported in part by the Taiwan Ministry of Health and
   Welfare Clinical Trial and Research Center of Excellence
   (MOHW105-TDU-B-212-133019); China Medical University Hospital (CMU),
   Academia Sinica Taiwan Biobank Stroke Biosignature Project
   (BM10501010037); NRPB Stroke Clinical Thai Consortium (MOST
   104-2325-B-039-005): Tseng-Lien Lin Foundation, Taichung, Taiwan; Taiwan
   Brain Disease Foundation, Taipei, Taiwan; Katsuzo and Kiyo Aoshima
   Memorial Funds, Japan; and CMU under the Aim for Top University Plan of
   the Ministry of Education, Taiwan. The funders had no role in the study
   design, data collection and analysis, decision to publish, or
   preparation of the manuscript. No additional external funding was
   received for this study.
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NR 37
TC 26
Z9 28
U1 0
U2 7
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD JUL
PY 2016
VL 95
IS 27
AR e4089
DI 10.1097/MD.0000000000004089
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA DS1QW
UT WOS:000380372400048
PM 27399102
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Bauman, D
AF Bauman, Dvora
TI Impact of obesity on female puberty and pubertal disorders
SO BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
LA English
DT Article
DE Obesity; Adolescent; Precocious puberty; Menstrual cycle; Polycystic
   ovary syndrome; Physical activity; Intervention program; D. Bauman
ID POLYCYSTIC-OVARY-SYNDROME; BODY-MASS INDEX; ALL-CAUSE; DIAGNOSIS;
   CHILDREN; ADOLESCENTS; RISKS; AGE
AB The worldwide epidemic of obesity appears to be one of the crucial health problems. One-third of children and adolescents in the United States are classified as either overweight or obese and 6% of adolescents are severely obese. With the development of high technology, children, and adolescents, spend more time in sedentary life. Together with the availability of consuming fast caloric food, it is almost unavoidable to get an imbalance between caloric intake and caloric expenditure of energy, resulting in the accumulation of fat-energy stores. Obesity has an enormous impact on physical and psychological health and is associated with more than 29 adverse health consequences previously identified in the adult population only, such as type 2 diabetes mellitus, hypertension, metabolic syndrome, postmenopausal breast cancer, and others. In addition, excess adiposity may exert a harmful effect on the reproductive system, resulting in precocious puberty, irregular menstrual cycle, polycystic ovary syndrome, and high-risk sexual behavior. Intervention programs for healthy lifestyle modification, consisting of caloric restriction together with physical activity did not gain the expected efficacy. Other approaches as medical and surgical therapies are currently not evidence-based for the young population. The obesity crisis in children and adolescents requires a better understanding of etiology, pathophysiology, and management of obesity in this unique population. Researchers and physicians must "turn over every stone" to find a solution for deviating obesity ascent. (c) 2023 Elsevier Ltd. All rights reserved.
C1 [Bauman, Dvora] Hebrew Univ Jerusalem, Fac Med, Hadassah Med Ctr, Bat Ami Ctr,Pediat & Adolescent Gynecol Div,Obstet, POB 12000, IL-91120 Jerusalem, Israel.
C3 Hebrew University of Jerusalem; Hadassah University Hospital; Hadassah
   University Medical Center
RP Bauman, D (corresponding author), Hebrew Univ Jerusalem, Fac Med, Hadassah Med Ctr, Bat Ami Ctr,Pediat & Adolescent Gynecol Div,Obstet, POB 12000, IL-91120 Jerusalem, Israel.
EM baumandvora@gmail.com
RI Bauman, Dvora/JGM-9983-2023
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NR 42
TC 9
Z9 9
U1 1
U2 8
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 1521-6934
EI 1532-1932
J9 BEST PRACT RES CL OB
JI Best Pract. Res. Clin. Obstet. Gynaecol.
PD DEC
PY 2023
VL 91
AR 102400
DI 10.1016/j.bpobgyn.2023.102400
EA SEP 2023
PG 17
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA T4WG5
UT WOS:001078001300001
PM 37708835
DA 2025-06-11
ER

PT J
AU Tabrizi, JS
   Nikniaz, L
   Sadeghi-Bazargani, H
   Farahbakhsh, M
   Nikniaz, Z
   Abbasalizad Farhangi, M
   Eghbali, E
AF Tabrizi, Jafar Sadegh
   Nikniaz, Leila
   Sadeghi-Bazargani, Homayoun
   Farahbakhsh, Mostafa
   Nikniaz, Zeinab
   Abbasalizad Farhangi, Mahdieh
   Eghbali, Elham
TI Prevalence of Dyslipidemia in Urban and Rural Areas of the Northwest of
   Iran: The Sociodemographic, Dietary and Psychological Determinants
SO IRANIAN JOURNAL OF PUBLIC HEALTH
LA English
DT Article
DE Dietary intake; Dyslipidemia; Iran; Smoking; Anxiety
ID DENSITY-LIPOPROTEIN CHOLESTEROL; RISK-FACTORS; METABOLIC SYNDROME;
   POPULATION
AB Background: As dyslipidemia is a preventable risk factor for Coronary heart disease (CHD), precise estimation of its prevalence and determinants is crucial for proper development of health actions. This population-based study aimed at investigating the socioeconomic, dietary and psychological determinants of dyslipidemia in Iran.
   Methods: The data (n=700) for this study were collected in 2015 as a part of the major Lifestyle Promotion Project (LPP) conducted in East Azerbaijan (urban and regional parts). The data for socio-demographic status, dietary information, and physical activity and anxiety levels were collected through validated questionnaires. Then, physical examinations including blood pressure, body mass index (BMI) and conicity index were performed. The levels of serum lipids were measured by enzymatic colorimetric methods.
   Results: The prevalence of hypercholesterolemia, high LDL-C, hypertriglyceridemia, low HDL-C and dyslipidemia was 29.4%, 10.3%, 62.3%, 41.4%, 83.3% respectively. The mean TC (184.3 +/- 41.2 vs. 174.5 +/- 38.1 mg/dl), LDL-C (94.6 +/- 30.3 vs. 88.1 +/- 28.7 mg/dl) and HDL-C (46.7 +/- 10.4 vs. 39.5 +/- 8.0 mg/dl) in women were significantly higher than men (P<0.05). However, the mean of TG (182.3 +/- 119.3 vs. 145.1 +/- 87.8 mg/dl) was significantly higher in men compared to women (P<0.05). Obesity, family history of dyslipidemia, sedentary lifestyle, smoking habits, salt intake, and anxiety were risk factors for different components of dyslipidemia in men and women.
   Conclusion: Dyslipidemia is a major health problem in northwest of Iran. Focusing on screening, regular drug intake, proper nutrition, physical activity, and changing lifestyles of patients with dyslipidemia are essential.
C1 [Tabrizi, Jafar Sadegh] Tabriz Univ Med Sci, Fac Management & Med Informat, Tabriz Hlth Serv Management Res Ctr, Tabriz, Iran.
   [Nikniaz, Leila] Tabriz Univ Med Sci, Tabriz Hlth Serv Management Res Ctr, Tabriz, Iran.
   [Sadeghi-Bazargani, Homayoun] Tabriz Univ Med Sci, Rd Traff Injury Res Ctr, Dept Stat & Epidemiol, Tabriz, Iran.
   [Farahbakhsh, Mostafa] Tabriz Univ Med Sci, Res Ctr Psychiat & Behav Sci, Tabriz, Iran.
   [Nikniaz, Zeinab; Eghbali, Elham] Tabriz Univ Med Sci, Liver & Gastrointestinal Dis Res Ctr, Tabriz, Iran.
   [Abbasalizad Farhangi, Mahdieh] Tabriz Univ Med Sci, Drug Appl Res Ctr, Tabriz, Iran.
C3 Tabriz University of Medical Science; Tabriz University of Medical
   Science; Tabriz University of Medical Science; Tabriz University of
   Medical Science; Tabriz University of Medical Science; Tabriz University
   of Medical Science
RP Eghbali, E (corresponding author), Tabriz Univ Med Sci, Liver & Gastrointestinal Dis Res Ctr, Tabriz, Iran.
EM egbali-e@yahoo.com
RI Sadeghi-Bazargani, Homayoun/M-5522-2017; eghbali, elham/AAP-9422-2020;
   Nikniaz, Leila/M-5747-2017; Farhangi, Mahdieh/AAC-6758-2019;
   Farahbakhsh, Mostafa/F-3748-2018; nikniaz, zeinab/L-5912-2017; Tabrizi,
   Jafar Sadegh/L-5036-2017
OI Tabrizi, Jafar Sadegh/0000-0002-1458-8672
FU East Azerbaijan Provincial Health Center; Tabriz Health Services
   Management Research Center at Tabriz University of Medical Sciences
FX The authors wish to thank East Azerbaijan Provincial Health Center,
   Tabriz Health Services Management Research Center at Tabriz University
   of Medical Sciences and Eastern Azerbaijan Governor General for
   financial support.
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NR 25
TC 8
Z9 8
U1 0
U2 5
PU IRANIAN SCIENTIFIC SOCIETY MEDICAL ENTOMOLOGY
PI TEHRAN
PA SCHOOL PUBLIC HEALTH & INST HEALTH RESEARCH, TEHRAN UNIV MEDICAL
   SCIENCES, P O BOX  6446-14155, TEHRAN, 00000, IRAN
SN 2251-6085
EI 2251-6093
J9 IRAN J PUBLIC HEALTH
JI Iran J. Public Health
PD MAY
PY 2019
VL 48
IS 5
BP 925
EP 933
PG 9
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA IE9DS
UT WOS:000472675700017
PM 31523650
DA 2025-06-11
ER

PT J
AU Perdomo, CM
   Avilés-Olmos, I
   Dicker, D
   Frühbeck, G
AF Perdomo, Carolina M.
   Aviles-Olmos, Iciar
   Dicker, Dror
   Fruhbeck, Gema
TI Towards an adiposity-related disease framework for the diagnosis and
   management of obesities
SO REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
LA English
DT Article
DE Obesity; Visceral adipose tissue; Cardiovascular disease;
   Adiposity-based chronic disease; Obesity-related adipose tissue disease;
   Adiposopathy
ID FATTY LIVER-DISEASE; BODY-MASS INDEX; CARDIOMETABOLIC RISK-FACTORS; Y
   GASTRIC BYPASS; TO-HEIGHT RATIO; WEIGHT-LOSS; CARDIOVASCULAR-DISEASE;
   INSULIN-RESISTANCE; KIDNEY-DISEASE; ADIPOCYTE SIZE
AB Obesity is a complex disease that relapses frequently and associates with multiple complications that comprise a worldwide health priority because of its rising prevalence and association with numerous complications, including metabolic disorders, mechanic pathologies, and cancer, among others. Noteworthy, excess adiposity is accompanied by chronic inflammation, oxidative stress, insulin resistance, and subsequent organ dysfunction. This dysfunctional adipose tissue is initially stored in the visceral depot, overflowing subsequently to produce lipotoxicity in ectopic depots like liver, heart, muscle, and pancreas, among others. People living with obesity need a diagnostic approach that considers an exhaustive pathophysiology and complications assessment. Thus, it is essential to warrant a holistic diagnosis and management that guarantees an adequate health status, and quality of life. The present review summarizes the different complications associated with obesity, at the same time, we aim to fostering a novel framework that enhances a patient-centered approach to obesity management in the precision medicine era.
C1 [Perdomo, Carolina M.; Fruhbeck, Gema] Univ Navarra, Dept Endocrinol & Nutr, Pamplona, Spain.
   [Perdomo, Carolina M.; Aviles-Olmos, Iciar; Fruhbeck, Gema] IdiSNA Inst Invest Salud Navarra, Pamplona, Spain.
   [Perdomo, Carolina M.; Fruhbeck, Gema] Inst Salud Carlos III, CIBEROBN, Madrid, Spain.
   [Aviles-Olmos, Iciar] Clin Univ Navarra, Dept Neurol, Pamplona, Spain.
   [Dicker, Dror] Hasharon Hosp, Rabin Med Ctr, Dept Internal Med D, Petah Tiqwa, Israel.
   [Dicker, Dror] Tel Aviv Univ, Sackler Sch Med, Tel Aviv, Israel.
C3 University of Navarra; Instituto de Salud Carlos III; CIBER - Centro de
   Investigacion Biomedica en Red; CIBEROBN; University of Navarra; Rabin
   Medical Center; Tel Aviv University; Sackler Faculty of Medicine
RP Frühbeck, G (corresponding author), Univ Navarra, Dept Endocrinol & Nutr, Pamplona, Spain.; Frühbeck, G (corresponding author), IdiSNA Inst Invest Salud Navarra, Pamplona, Spain.; Frühbeck, G (corresponding author), Inst Salud Carlos III, CIBEROBN, Madrid, Spain.
EM gfruhbeck@unav.es
OI Dicker, Dror/0000-0001-8546-6245; Fruhbeck, Gema/0000-0002-8305-7154;
   Perdomo, Carolina M./0000-0002-5748-0581
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NR 138
TC 20
Z9 21
U1 1
U2 9
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1389-9155
EI 1573-2606
J9 REV ENDOCR METAB DIS
JI Rev. Endocr. Metab. Disord.
PD OCT
PY 2023
VL 24
IS 5
SI SI
BP 795
EP 807
DI 10.1007/s11154-023-09797-2
EA MAY 2023
PG 13
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA R1PW0
UT WOS:000985281800001
PM 37162651
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Delgado-Floody, P
   Cofré-Lizama, A
   Guzmán-Guzmán, IP
   Mayorga, DJ
   Martínez-Salazar, C
   Caamaño-Navarrete, F
AF Delgado-Floody, Pedro
   Cofre-Lizama, Alfonso
   Paola Guzman-Guzman, Iris
   Jerez Mayorga, Daniel
   Martinez-Salazar, Cristian
   Caamano-Navarrete, Felipe
TI Perception of obese schoolchildren regarding their participation in the
   Physical Education class and their level of self-esteem: comparison
   according to corporal status
SO NUTRICION HOSPITALARIA
LA English
DT Article
DE Schoolchildren; Physical Education; Self-esteem; Obesity
ID BODY-MASS INDEX; QUALITY-OF-LIFE; CHILDHOOD OBESITY; CARDIOMETABOLIC
   RISK; CHILDREN; HEALTH; ADOLESCENTS; DEPRESSION; DISSATISFACTION;
   ASSOCIATION
AB Background: adequate exposure to Physical Education (PE) classes contributes to a healthier lifestyle among children during their lifespan.
   Objective: the main objective of this research was to evaluate the perception of obese schoolchildren regarding their participation in PE class and to determine their self-esteem compared with overweight and normal weight groups.
   Method: in total, 656 schoolchildren (284 females and 372 males), between eleven and 14 years of age, participated in this study. Assessments were made regarding age, sex, anthropometric variables, children's self-esteem, and perception of participation in the PE class.
   Results: obese schoolchildren presented significantly lower values of self-esteem (p < 0.001), and exhibited the highest proportion of schoolchildren with low self-esteem (53%). There was a significant relationship between obesity and the following sentence: "I am the last one they choose for games and in games and sports"; 48.53% of schoolchildren with obesity responded positively. With the following sentence: "I look instead of playing", 57.4% of schoolchildren with obesity responded positively.
   Conclusion: the results revealed that schoolchildren with obesity feel excluded from PE classes and show low levels of self-esteem, compared with normal weight schoolchildren.
C1 [Delgado-Floody, Pedro; Martinez-Salazar, Cristian] Univ La Frontera, Dept Phys Educ Sports & Recreat, Av Francisco Salazar, Temuco 01145, Chile.
   [Cofre-Lizama, Alfonso] Univ Santo Tomas, Fac Social Sci, Sch Psychol, Temuco, Chile.
   [Cofre-Lizama, Alfonso] Univ Mayor, Las Condes, Chile.
   [Paola Guzman-Guzman, Iris] Univ Autonoma Guerrero, Fac Biol Chem Sci, Guerrero, Mexico.
   [Jerez Mayorga, Daniel] Univ Andres Bello, Fac Rehabil Sci, Santiago, Chile.
   [Caamano-Navarrete, Felipe] Univ Catolica Temuco, Fac Educ, Phys Educ Pedag, Temuco, Chile.
C3 Universidad de La Frontera; Universidad Santo Tomas; Universidad Mayor;
   Universidad Andres Bello; Universidad Catolica de Temuco
RP Delgado-Floody, P (corresponding author), Univ La Frontera, Dept Phys Educ Sports & Recreat, Av Francisco Salazar, Temuco 01145, Chile.
EM pedro.delgado@ufrontera.cl
RI Jerez-Mayorga, Daniel/GQP-1860-2022; Delgado-Floody, Pedro/D-9779-2019
OI COFRE LIZAMA, ALFONSO JESUS/0000-0001-9938-0506; Delgado-Floody,
   Pedro/0000-0001-9952-993X; Jerez Mayorga, Daniel/0000-0002-6878-8004
CR Abos A, 2016, EUR PHYS EDUC REV
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NR 32
TC 4
Z9 4
U1 1
U2 22
PU ARAN EDICIONES, S L
PI MADRID
PA C/ CASTELLO, 128, 1O, MADRID, 28006, SPAIN
SN 0212-1611
EI 1699-5198
J9 NUTR HOSP
JI Nutr. Hosp.
PD NOV-DEC
PY 2018
VL 35
IS 6
BP 1270
EP 1274
DI 10.20960/nh.1786
PG 5
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA HG6IZ
UT WOS:000455086100004
PM 30525839
OA gold
DA 2025-06-11
ER

PT J
AU Myhrstad, MCW
   Wolk, A
AF Myhrstad, Mari C. W.
   Wolk, Alicja
TI Antioxidants and phytochemicals - a scoping review for Nordic
SO FOOD & NUTRITION RESEARCH
LA English
DT Review
DE antioxidants; phytochemicals; phenols; oxidative stress; resveratrol;
   nutrition recommendations
ID RESVERATROL SUPPLEMENTATION; POLYPHENOL METABOLITES; DIETARY
   ANTIOXIDANTS; CAPACITY; METAANALYSIS; DISEASE; PLASMA; RISK
AB Antioxidants are a collection of substances that may prevent or delay the oxidation of cellular components. The antioxidant defense system includes both endogenously produced antioxidants and dietary antioxidants. The consumption of dietary antioxidants has long been speculated to be important for the defense against cellular oxidation, inflammation, and other disease-related processes. In addition to the well-known dietary antioxidants, such as vitamin C, vitamin E, beta-carotene, and selenium, whole plants and plant-products contain numerous compounds, called phytochemicals, with antioxidant properties. These phytochemicals are potentially important modulators of oxidative stress and have been linked to health beneficial effects. However, the mechanisms underlying these potential health beneficial effects are not well understood. Foods containing high levels of phytochemicals with antioxidant properties include berries, fruits, vegetables, whole grains, and nuts and seeds. The aim of this scoping review is to describe the evidence of the role of specific antioxidants and phytochemicals, but not foods rich in these substances, for health outcomes. Based on a literature search from 2011 to March 2022, we identified eight meta-analyses related to the current topic. These studies include evidence of the effect of resveratrol (present mainly in berries, grapes, and peanuts) on health outcomes related to cardiometabolic risk, blood pressure, obesity, oxidative stress, adipokines, inflammation, and bone quality. In summary, resveratrol did elicit several health beneficial effects. However, the magnitude of effects was low, and whether the effects are related to the redox properties of resveratrol is not known. Even though there is a large body of evidence linking a plant-based diet rich in antioxidants and phytochemicals to beneficial health effects, the role of specific antioxidants and phytochemicals is still unclear.
C1 [Myhrstad, Mari C. W.] Oslo Metropolitan Univ, Fac Hlth Sci, Dept Nursing & Hlth Promot, Oslo, Norway.
   [Wolk, Alicja] Karolinska Inst, Inst Environm Med, Stockholm, Sweden.
C3 Oslo Metropolitan University (OsloMet); Karolinska Institutet
RP Myhrstad, MCW (corresponding author), Oslo Metropolitan Univ, Fac Hlth Sci, Dept Nursing & Hlth Promot, Oslo, Norway.
EM mmyhrsta@oslomet.no
RI Myhrstad, Mari/ABE-7132-2021
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NR 52
TC 3
Z9 3
U1 5
U2 29
PU SWEDISH NUTRITION FOUNDATION-SNF
PI LUND
PA IDEON SCIENCE PARK, BESOK SCHEELEV 17 BETA 5, 3V, LUND, 223 70, SWEDEN
SN 1654-6628
EI 1654-661X
J9 FOOD NUTR RES
JI Food Nutr. Res.
PD DEC 1
PY 2023
VL 67
AR 10324
DI 10.29219/fnr.v67.10324
PG 10
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA FG3X5
UT WOS:001144581200001
PM 38084155
OA gold
DA 2025-06-11
ER

PT J
AU Burghardt, PR
   Krolewski, DM
   Dykhuis, KE
   Ching, J
   Pinawin, AM
   Britton, SL
   Koch, LG
   Watson, SJ
   Akil, H
AF Burghardt, P. R.
   Krolewski, D. M.
   Dykhuis, K. E.
   Ching, J.
   Pinawin, A. M.
   Britton, S. L.
   Koch, L. G.
   Watson, S. J.
   Akil, H.
TI Nucleus accumbens cocaine-amphetamine regulated transcript mediates food
   intake during novelty conflict
SO PHYSIOLOGY & BEHAVIOR
LA English
DT Article
DE Behavior; Conflict; Ingestion; Novelty; Metabolism
ID INTRINSIC AEROBIC CAPACITY; CART PEPTIDE; MESSENGER-RNA; BODY-WEIGHT;
   METABOLIC SYNDROME; STRESS; RATS; ANXIETY; DOPAMINE; RECEPTORS
AB Obesity is a persistent and pervasive problem, particularly in industrialized nations. It has come to be appreciated that the metabolic health of an individual can influence brain function and subsequent behavioral patterns. To examine the relationship between metabolic phenotype and central systems that regulate behavior, we tested rats with divergent metabolic phenotypes (Low Capacity Runner: LCR vs. High Capacity Runner: HCR) for behavioral responses to the conflict between hunger and environmental novelty using the novelty suppressed feeding (NSF) paradigm. Additionally, we measured expression of mRNA, for peptides involved in energy management, in response to fasting. Following a 24-h fast, LCR rats showed lower latencies to begin eating in a novel environment compared to HCR rats. A 48-h fast equilibrated the latency to begin eating in the novel environment. A 24-h fast differentially affected expression of cocaine-amphetamine regulated transcript (CART) mRNA in the nucleus accumbens (NAc), where 24-h of fasting reduced CART mRNA in LCR rats. Bilateral microinjections of CART 55-102 peptide into the NAc increased the latency to begin eating in the NSF paradigm following a 24-h fast in LCR rats. These results indicate that metabolic phenotype influences how animals cope with the conflict between hunger and novelty, and that these differences are at least partially mediated by CART signaling in the NAc. For individuals with poor metabolic health who have to navigate food-rich and stressful environments, changes in central systems that mediate conflicting drives may feed into the rates of obesity and exacerbate the difficulty individuals have in maintaining weight loss. (C) 2016 Elsevier Inc. All rights reserved.
C1 [Burghardt, P. R.; Watson, S. J.; Akil, H.] Univ Michigan, Dept Psychiat, Ann Arbor, MI 48109 USA.
   [Krolewski, D. M.; Dykhuis, K. E.; Ching, J.; Pinawin, A. M.; Watson, S. J.; Akil, H.] Univ Michigan, Mol & Behav Neurosci Inst, Ann Arbor, MI 48109 USA.
   [Britton, S. L.; Koch, L. G.] Univ Michigan, Dept Anesthesiol, Ann Arbor, MI 48109 USA.
   [Britton, S. L.] Univ Michigan, Dept Mol & Integrat Physiol, Ann Arbor, MI 48109 USA.
   [Burghardt, P. R.] Wayne State Univ, Dept Nutr & Food Sci, Detroit, MI 48202 USA.
C3 University of Michigan System; University of Michigan; University of
   Michigan System; University of Michigan; University of Michigan System;
   University of Michigan; University of Michigan System; University of
   Michigan; Wayne State University
RP Burghardt, PR (corresponding author), Wayne State Univ, Nutr & Food Sci, 5000 Gullen Mall, Detroit, MI 48202 USA.
EM paul.burghardt@wayne.edu
RI Koch, Lauren/D-1258-2010
FU NIDDK [DK092322]; ONR [N00014-09-1-0598, N00014-12-1-0366, R01MH104261];
   Hope for Depression Research Foundation;  [R24RR017718];  [R24OD010950];
    [R01DK099034]
FX We would like to thank Jim Stewart for technical assistance on the
   project. This work was supported by NIDDK grant DK092322 (PRB), ONR
   N00014-09-1-0598 and N00014-12-1-0366, R01MH104261, and the Hope for
   Depression Research Foundation (Akil and SJ Watson). The LCR-HCR rat
   model system was funded by R24RR017718, R24OD010950, and R01DK099034
   (LGK and SLB). We acknowledge the expert care of the rat colony provided
   by Molly Kalahar and Lori Heckenkamp. Contact LGK (lgkoch@med.umich.edu)
   or SLB (brittons@umich.edu) for information on the LCR and HCR rats:
   these rat models are maintained as an international resource with
   support from the Department of Anesthesiology at the University of
   Michigan, Ann Arbor, Michigan.
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NR 65
TC 5
Z9 5
U1 0
U2 11
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0031-9384
J9 PHYSIOL BEHAV
JI Physiol. Behav.
PD MAY 1
PY 2016
VL 158
BP 76
EP 84
DI 10.1016/j.physbeh.2016.02.035
PG 9
WC Psychology, Biological; Behavioral Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Behavioral Sciences
GA DK0MU
UT WOS:000374607700011
PM 26926827
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Pei, L
   Yang, J
   Du, J
   Liu, HQ
   Ao, N
   Zhang, YY
AF Pei, Lina
   Yang, Jing
   Du, Jian
   Liu, Huiqiang
   Ao, Na
   Zhang, Yingyan
TI Downregulation of chemerin and alleviation of endoplasmic reticulum
   stress by metformin in adipose tissue of rats
SO DIABETES RESEARCH AND CLINICAL PRACTICE
LA English
DT Article
DE Metformin; Insulin resistance; Chemerin expression
ID VIVO ER STRESS; INSULIN-RESISTANCE; METABOLIC SYNDROME; KAPPA-B;
   OBESITY; ACTIVATION; ADIPOKINE; IRE1; GENE
AB Aims: To investigate whether metformin regulates chemerin expression in vivo by alleviating ER stress.
   Methods: Male Sprague-Dawley rats were fed a high-fat or normal diet for 10 weeks to induce insulin resistance. During the following 6 weeks, the rats were divided into four groups: normal diet without treatment (NC), normal diet with metformin treatment (NM), high-fat diet without metformin (HF), and high-fat diet with metformin (HM). Body weight, fasting glucose, basal insulin level, insulin sensitivity, chemerin expression in serum and adipose tissue, ER stress marker and its pathway were measured.
   Results: After 6 weeks treatment, metformin reduced the body weight gain and enhanced insulin sensitivity of high-fat fed rats. The basal insulin level in the HM group was lower than in the HF group. Metformin reduced chemerin expression in the HM group compared with HF. Metformin reduced the GRP78 mRNA expression in HM rats. Activation of IRE1 alpha was lower in the HM group than the HF group.
   Conclusions: Metformin treatment decreased the chemerin expression and alleviated the ER stress in the visceral adipose tissue of high-fat diet-induced insulin-resistant rats. These data may also provide a further rationale for exploring the use of metformin in the treatment of insulin resistance. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
C1 [Pei, Lina; Yang, Jing; Du, Jian; Liu, Huiqiang; Ao, Na; Zhang, Yingyan] China Med Univ, Affiliated Hosp 1, Dept Endocrinol & Metab, Shenyang, Peoples R China.
C3 China Medical University
RP Du, J (corresponding author), China Med Univ, Affiliated Hosp 1, Dept Endocrinol & Metab, Shenyang, Peoples R China.
EM dujian.com@medmail.com.cn
RI Zhang, Yingyan/A-2569-2012; Du, Jian/IXD-1367-2023
FU Hall of Science [2009225029]; Hall of Education of Liaoning [L2010597]
FX This work was supported by grants from the Hall of Science (2009225029)
   and the Hall of Education of Liaoning (L2010597).
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NR 31
TC 12
Z9 15
U1 0
U2 4
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0168-8227
EI 1872-8227
J9 DIABETES RES CLIN PR
JI Diabetes Res. Clin. Pract.
PD AUG
PY 2012
VL 97
IS 2
BP 267
EP 275
DI 10.1016/j.diabres.2012.02.023
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 993AE
UT WOS:000307823400020
PM 22445233
DA 2025-06-11
ER

PT J
AU Kang, H
   Kim, B
AF Kang, Hyunju
   Kim, Bohkyung
TI Bioactive Compounds as Inhibitors of Inflammation, Oxidative Stress and
   Metabolic Dysfunctions via Regulation of Cellular Redox Balance and
   Histone Acetylation State
SO FOODS
LA English
DT Review
DE bioactive compounds; anti-inflammation; anti-oxidative stress;
   anti-metabolic syndrome; cellular redox balance; histone acetylation
ID NF-KAPPA-B; HIGH-FAT DIET; SMALL-MOLECULE ACTIVATORS; CHRONIC ETHANOL
   EXPOSURE; CUL3-BASED E3 LIGASE; ACUTE LIVER-INJURY; NICOTINAMIDE
   RIBOSIDE; HEPATIC STEATOSIS; REACTIVE OXYGEN; GREEN TEA
AB Bioactive compounds (BCs) are known to exhibit antioxidant, anti-inflammatory, and anti-cancer properties by regulating the cellular redox balance and histone acetylation state. BCs can control chronic oxidative states caused by dietary stress, i.e., alcohol, high-fat, or high-glycemic diet, and adjust the redox balance to recover physiological conditions. Unique functions of BCs to scavenge reactive oxygen species (ROS) can resolve the redox imbalance due to the excessive generation of ROS. The ability of BCs to regulate the histone acetylation state contributes to the activation of transcription factors involved in immunity and metabolism against dietary stress. The protective properties of BCs are mainly ascribed to the roles of sirtuin 1 (SIRT1) and nuclear factor erythroid 2-related factor 2 (NRF2). As a histone deacetylase (HDAC), SIRT1 modulates the cellular redox balance and histone acetylation state by mediating ROS generation, regulating nicotinamide adenine dinucleotide (NAD+)/NADH ratio, and activating NRF2 in metabolic progression. In this study, the unique functions of BCs against diet-induced inflammation, oxidative stress, and metabolic dysfunction have been considered by focusing on the cellular redox balance and histone acetylation state. This work may provide evidence for the development of effective therapeutic agents from BCs.
C1 [Kang, Hyunju] Keimyung Univ, Dept Food & Nutr, Daegu 42601, South Korea.
   [Kim, Bohkyung] Pusan Natl Univ, Dept Food Sci & Nutr, Busan 46241, South Korea.
C3 Keimyung University; Pusan National University
RP Kim, B (corresponding author), Pusan Natl Univ, Dept Food Sci & Nutr, Busan 46241, South Korea.
EM bohkyung.kim@pusan.ac.kr
OI Kang, Hyunju/0000-0002-6061-2928
FU National Research Foundation of Korea (NRF) - Korean government (MSIT)
   [RS-2022-00165604, NRF-2019R1A2C1089200]
FX This work was supported by the National Research Foundation of Korea
   (NRF) grant funded by the Korean government (MSIT) (No. RS-2022-00165604
   and NRF-2019R1A2C1089200).
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NR 255
TC 21
Z9 21
U1 1
U2 23
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2304-8158
J9 FOODS
JI Foods
PD MAR
PY 2023
VL 12
IS 5
AR 925
DI 10.3390/foods12050925
PG 28
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA 9U1SO
UT WOS:000947499900001
PM 36900446
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Friedman, EM
   Karlamangla, AS
   Almeida, DM
   Seeman, TE
AF Friedman, Esther M.
   Karlamangla, Arun S.
   Almeida, David M.
   Seeman, Teresa E.
TI Social strain and cortisol regulation in midlife in the US
SO SOCIAL SCIENCE & MEDICINE
LA English
DT Article
DE USA; Biological markers; Cortisol; Diurnal rhythm; Social relationships;
   Social strain; Midlife in the US (MIDUS); Stress; Family
ID CORONARY-HEART-DISEASE; PHYSIOLOGICAL PROCESSES; SOCIOECONOMIC-STATUS;
   METABOLIC SYNDROME; STRESS; HEALTH; SUPPORT; ENVIRONMENT; LONELINESS;
   MORTALITY
AB Chronic stress has been implicated in a variety of adverse health outcomes, from compromised immunity to cardiovascular disease to cognitive decline. The hypothalamic pituitary adrenal (HPA) axis has been postulated to play the primary biological role in translating chronic stress into ill health. Stressful stimuli activate the HPA-axis and cause an increase in circulating levels of cortisol. Frequent and long-lasting activation of the HPA-axis, as occurs in recurrently stressful environments, can in the long run compromise HPA-axis functioning and ultimately affect health. Negative social interactions with family and friends may be a significant source of stress in daily life, constituting the type of recurrently stressful environment that could lead to compromised HPA functioning and altered diurnal cortisol rhythms. We use data from two waves (1995 and 2004-2005) of the Midlife in the U.S. (MIDUS) study and from the National Study of Daily Experiences (NSDE) and piecewise growth curve models to investigate relationships between histories of social strain and patterns of diurnal cortisol rhythms. We find that reported levels of social strain were significantly associated with their diurnal cortisol rhythm. These effects were more pronounced for individuals with a history of greater reported strain across a ten-year period. (C) 2011 Elsevier Ltd. All rights reserved.
C1 [Friedman, Esther M.] Harvard Univ, Harvard Ctr Populat & Dev Studies, Cambridge, MA 02138 USA.
   [Karlamangla, Arun S.; Seeman, Teresa E.] Univ Calif Los Angeles, Los Angeles, CA USA.
   [Almeida, David M.] Penn State Univ, University Pk, PA 16802 USA.
C3 Harvard University; Harvard T.H. Chan School of Public Health;
   University of California System; University of California Los Angeles;
   Pennsylvania Commonwealth System of Higher Education (PCSHE);
   Pennsylvania State University; Penn State Behrend; Pennsylvania State
   University - University Park
RP Friedman, EM (corresponding author), Harvard Univ, Harvard Ctr Populat & Dev Studies, 9 Bow St, Cambridge, MA 02138 USA.
EM friedman@hsph.harvard.edu
FU National Institute on Aging [P01-AG020166, R01-AG19239, R01-AG019239,
   P30-AG028748]; John D. and Catherine T. MacArthur Foundation Research
   Network on Successful Mid life Development; UCLA Older Americans
   Independence Center; National Science Foundation
FX This research was supported, in part, by Grants P01-AG020166,
   R01-AG19239, and R01-AG019239 from the National Institute on Aging to
   conduct a longitudinal follow-up of the MIDUS (Mid life in the United
   States) investigation. The original study was supported by the John D.
   and Catherine T. MacArthur Foundation Research Network on Successful Mid
   life Development. The project described also received support from the
   UCLA Older Americans Independence Center, Grant P30-AG028748 from the
   National Institute on Aging. The content is solely the responsibility of
   the authors and does not necessarily represent the official views of the
   National Institute on Aging or the National Institutes of Health. The
   authors thank the Robert Wood Johnson Foundation Health & Society
   Scholars program and the UCLA Interdisciplinary Relationship Science
   Program sponsored by the National Science Foundation for their financial
   support. We are also grateful to Rob Mare, Judy Seltzer, and the members
   of the UCLA demography, family, and stratification research group for
   helpful advice as we developed the paper. A previous version of this
   paper was presented at the 2008 meeting of the Gerontological Society of
   America (GSA), National Harbor, MD.
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NR 61
TC 55
Z9 69
U1 0
U2 25
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0277-9536
J9 SOC SCI MED
JI Soc. Sci. Med.
PD FEB
PY 2012
VL 74
IS 4
BP 607
EP 615
DI 10.1016/j.socscimed.2011.11.003
PG 9
WC Public, Environmental & Occupational Health; Social Sciences, Biomedical
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; Biomedical Social Sciences
GA 902CY
UT WOS:000301017400019
PM 22209675
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Li, H
   Bian, YF
   Zhang, NN
   Guo, J
   Wang, C
   Lau, WB
   Xiao, CS
AF Li, Hong
   Bian, Yunfei
   Zhang, Nana
   Guo, Jia
   Wang, Cheng
   Lau, Wayne Bond
   Xiao, Chuanshi
TI Intermedin protects against myocardial ischemia-reperfusion injury in
   diabetic rats
SO CARDIOVASCULAR DIABETOLOGY
LA English
DT Article
DE Intermedin; Ischemia-reperfusion; Diabetes; Oxidative stress; Apoptosis;
   Inflammatory
ID NITRIC-OXIDE SYNTHASE; ACUTE CORONARY SYNDROME; OXIDATIVE STRESS; NADPH
   OXIDASE; CARDIAC DYSFUNCTION; INFARCT SIZE; ISCHEMIA/REPERFUSION INJURY;
   CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; SIGNALING PATHWAY
AB Background: Diabetic patients, through incompletely understood mechanisms, endure exacerbated ischemic heart injury compared to non-diabetic patients. Intermedin (IMD) is a novel calcitonin gene-related peptide (CGRP) superfamily member with established cardiovascular protective effects. However, whether IMD protects against diabetic myocardial ischemia/reperfusion (MI/R) injury is unknown.
   Methods: Diabetes was induced by streptozotocin in Sprague-Dawley rats. Animals were subjected to MI via left circumflex artery ligation for 30 minutes followed by 2 hours R. IMD was administered formally 10 minutes before R. Outcome measures included left ventricular function, oxidative stress, cellular death, infarct size, and inflammation.
   Results: IMD levels were significantly decreased in diabetic rats compared to control animals. After MI/R, diabetic rats manifested elevated intermedin levels, both in plasma (64.95 +/- 4.84 pmol/L, p < 0.05) and myocardial tissue (9.8 +/- 0.60 pmol/L, p < 0.01) compared to pre-MI control values (43.62 +/- 3.47 pmol/L and 4.4 +/- 0.41). IMD administration to diabetic rats subjected to MI/R decreased oxidative stress product generation, apoptosis, infarct size, and inflammatory cytokine release (p < 0.05 or p < 0.01).
   Conclusions: By reducing oxidative stress, inflammation, and apoptosis, IMD may represent a promising novel therapeutic target mitigating diabetic ischemic heart injury.
C1 [Li, Hong; Bian, Yunfei; Zhang, Nana; Guo, Jia; Wang, Cheng; Xiao, Chuanshi] Shanxi Med Univ, Dept Cardiol, Taiyuan 030001, Shanxi, Peoples R China.
   [Lau, Wayne Bond] Thomas Jefferson Univ, Dept Emergency Med, Philadelphia, PA 19107 USA.
C3 Shanxi Medical University; Thomas Jefferson University
RP Xiao, CS (corresponding author), Shanxi Med Univ, Dept Cardiol, Taiyuan 030001, Shanxi, Peoples R China.
EM xiaochuanshi55@gmail.com
OI Guo, Jia/0000-0002-4574-4543; Lau, Wayne Bond/0000-0002-8064-8290
FU Shanxi Medical University; second Hospital of Shanxi Medical University;
   Shanxi Provincial Health Department for Scientific and Technological
   Projects [20100106]
FX This work was supported by a grant from the Shanxi Medical University,
   the second Hospital of Shanxi Medical University, and the Shanxi
   Provincial Health Department for Scientific and Technological Projects
   (no. 20100106).
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NR 67
TC 78
Z9 81
U1 1
U2 31
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1475-2840
J9 CARDIOVASC DIABETOL
JI Cardiovasc. Diabetol.
PD JUN 18
PY 2013
VL 12
AR 91
DI 10.1186/1475-2840-12-91
PG 11
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism
GA 176ZT
UT WOS:000321346000001
PM 23777472
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Kalinowski, J
   Kaur, K
   Newsome-Garcia, V
   Langford, A
   Kalejaiye, A
   Vieira, D
   Izeogu, C
   Blanc, J
   Taylor, J
   Ogedegbe, O
   Spruill, T
AF Kalinowski, Jolaade
   Kaur, Kiran
   Newsome-Garcia, Valerie
   Langford, Aisha
   Kalejaiye, Ayoola
   Vieira, Dorice
   Izeogu, Chigozirim
   Blanc, Judite
   Taylor, Jacquelyn
   Ogedegbe, Olugbenga
   Spruill, Tanya
TI Stress interventions and hypertension in Black women
SO WOMENS HEALTH
LA English
DT Review
DE behavioral health; disparities; hypertension; stress; women's health
ID RANDOMIZED CONTROLLED-TRIAL; LIFE-STYLE MODIFICATION; AFRICAN-AMERICAN
   WOMEN; BLOOD-PRESSURE; PERCEIVED STRESS; CARDIOVASCULAR-DISEASE;
   MYOCARDIAL-INFARCTION; RISK-FACTORS; TRANSCENDENTAL-MEDITATION;
   METABOLIC SYNDROME
AB Hypertension is a risk factor for cardiovascular disease. Black women have high rates of hypertension compared to women of other racial or ethnic groups and are disproportionately affected by psychosocial stressors such as racial discrimination, gender discrimination, and caregiving stress. Evidence suggests that stress is associated with incident hypertension and hypertension risk. Stress management is associated with improvements improved blood pressure outcomes. The purpose of this review is to synthesize evidence on effects of stress management interventions on blood pressure in Black women. A comprehensive search of scientific databases was conducted. Inclusion criteria included studies that were: (1) primary research that tested an intervention; (2) in the English language; (3) included African-American women; (4) incorporated stress in the intervention; (5) included blood pressure as an outcome; and (6) were US based. Eighteen studies met inclusion criteria. Ten (56%) studies tested meditation-based interventions, two (11%) tested coping and affirmation interventions, and six (33%) tested lifestyle modification interventions that included stress management content. Thirteen of the studies were randomized controlled trials. Reductions in blood pressure were observed in all of the meditation-based interventions, although the magnitude and statistical significance varied. Comprehensive lifestyle interventions were also efficacious for reducing blood pressure, although the relative contribution of stress management versus behavior modification could not be evaluated. Coping and affirmation interventions did not affect blood pressure. Most of the reviewed studies included small numbers of Black women and did not stratify results by race and gender, so effects remain unclear. This review highlights the urgent need for studies specifically focusing on Black women. Given the extensive disparities in cardiovascular disease morbidity and mortality, whether stress management can lower blood pressure and improve primary and secondary cardiovascular disease prevention among Black women is an important question for future research.
C1 [Kalinowski, Jolaade] Univ Connecticut, Dept Human Dev & Family Sci, Storrs, CT 06269 USA.
   [Kaur, Kiran; Langford, Aisha; Vieira, Dorice; Izeogu, Chigozirim; Blanc, Judite; Ogedegbe, Olugbenga; Spruill, Tanya] NYU, Sch Med, Dept Populat Hlth, New York, NY USA.
   [Newsome-Garcia, Valerie] Morehouse Sch Med, Atlanta, GA 30310 USA.
   [Kalejaiye, Ayoola] Montefiore Med Ctr, 111 E 210th St, Bronx, NY 10467 USA.
   [Taylor, Jacquelyn] Columbia Univ, Sch Nursing, New York, NY USA.
C3 University of Connecticut; New York University; Morehouse School of
   Medicine; Montefiore Medical Center; Albert Einstein College of
   Medicine; Columbia University
RP Kalinowski, J (corresponding author), Univ Connecticut, Dept Human Dev & Family Sci, Storrs, CT 06269 USA.
EM jolaade.kalinowski@uconn.edu
RI Blanc, Judite/X-8162-2019; Vieira, Dorice/K-6229-2019
OI Spruill, Tanya/0000-0003-2998-3007; Langford, Aisha/0000-0003-1758-691X;
   Izeogu, Chigozirim/0000-0002-9263-6801; Blanc,
   Judite/0000-0002-4489-8604; Vieira, Dorice/0000-0003-4232-9413
FU National Institutes of Health [T32HL129953]; American Heart Association
   [19POST34380633]; National Heart Lung and Blood Institute [T32HL129953]
   Funding Source: NIH RePORTER; American Heart Association (AHA)
   [19POST34380633] Funding Source: American Heart Association (AHA)
FX The authors disclosed receipt of the following financial support for the
   research, authorship, and/or publication of this article: Preparation of
   this article was supported in part by the National Institutes of Health
   grant T32HL129953 -Mentoring URM Scientists in Behavioral and
   Cardiovascular Health to Increase Academic Workforce Diversity and
   American Heart Association grant 19POST34380633.
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NR 73
TC 0
Z9 0
U1 0
U2 0
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1745-5057
EI 1745-5065
J9 WOMENS HEALTH
JI Womens Health
PD JUL
PY 2021
VL 17
AR 17455065211009751
DI 10.1177/17455065211009751
PG 14
WC Obstetrics & Gynecology
WE Emerging Sources Citation Index (ESCI)
SC Obstetrics & Gynecology
GA UG8UG
UT WOS:000689519300001
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Ramírez-López, MT
   Vázquez, M
   Bindila, L
   Lomazzo, E
   Hofmann, C
   Blanco, RN
   Alén, F
   Antón, M
   Decara, J
   Ouro, D
   Orio, L
   Suarez, J
   Lutz, B
   de Fonseca, FR
   de Heras, RG
AF Teresa Ramirez-Lopez, Maria
   Vazquez, Mariam
   Bindila, Laura
   Lomazzo, Ermelinda
   Hofmann, Clementine
   Noemi Blanco, Rosario
   Alen, Francisco
   Anton, Maria
   Decara, Juan
   Ouro, Daniel
   Orio, Laura
   Suarez, Juan
   Lutz, Beat
   Rodriguez de Fonseca, Fernando
   Gomez de Heras, Raquel
TI Exposure to a Highly Caloric Palatable Diet During Pregestational and
   Gestational Periods Affects Hypothalamic and Hippocampal Endocannabinoid
   Levels at Birth and Induces Adiposity and Anxiety-Like Behaviors in Male
   Rat Offspring
SO FRONTIERS IN BEHAVIORAL NEUROSCIENCE
LA English
DT Article
DE maternal diet; endocannabinoids; adipogenesis; anxiety; development;
   hypothalamus; hippocampus
ID HIGH-FAT DIET; CB1 CANNABINOID RECEPTOR; CATCH-UP GROWTH; JUNK FOOD
   DIET; MATERNAL OBESITY; PROTEIN-MALNUTRITION; ENERGY HOMEOSTASIS;
   METABOLIC SYNDROME; EATING BEHAVIOR; PREGNANCY
AB Exposure to unbalanced diets during pre-gestational and gestational periods may result in long-term alterations in metabolism and behavior. The contribution of the endocannabinoid system to these long-term adaptive responses is unknown. In the present study, we investigated the impact of female rat exposure to a hypercaloric-hypoproteic palatable diet during pre-gestational, gestational and lactational periods on the development of male offspring. In addition, the hypothalamic and hippocampal endocannabinoid contents at birth and the behavioral performance in adulthood were investigated. Exposure to a palatable diet resulted in low weight offspring who exhibited low hypothalamic contents of arachidonic acid and the two major endocannabinoids (anandamide and 2-arachidonoylglycerol) at birth. Palmitoylethanolamide, but not oleoylethanolamide, also decreased. Additionally, pups from palatable diet-fed dams displayed lower levels of anandamide and palmitoylethanolamide in the hippocampus. The low weight male offspring, born from palatable diet exposed mothers, gained less weight during lactation and although they recovered weight during the post-weaning period, they developed abdominal adiposity in adulthood. These animals exhibited anxiety like behavior in the elevated plus maze and open field test and a low preference for a chocolate diet in a food preference test, indicating that maternal exposure to a hypercaloric diet induces long-term behavioral alterations in male offspring. These results suggest that maternal diet alterations in the function of the endogenous cannabinoid system can mediate the observed phenotype of the offspring, since both hypothalamic and hippocampal endocannabinoids regulate feeding, metabolic adaptions to caloric diets, learning, memory, and emotions.
C1 [Teresa Ramirez-Lopez, Maria; Vazquez, Mariam; Noemi Blanco, Rosario; Alen, Francisco; Anton, Maria; Ouro, Daniel; Orio, Laura; Rodriguez de Fonseca, Fernando; Gomez de Heras, Raquel] Univ Complutense Madrid, Fac Psicol, Dept Psicobiol, Madrid, Spain.
   [Vazquez, Mariam; Decara, Juan; Orio, Laura; Rodriguez de Fonseca, Fernando] Univ Malaga, Hosp Reg Univ Malaga, Inst IBIMA, Unidad Gest Clin Salud Mental, E-29071 Malaga, Spain.
   [Bindila, Laura; Lomazzo, Ermelinda; Hofmann, Clementine; Lutz, Beat] Johannes Gutenberg Univ Mainz, Univ Med Ctr, Inst Physiol Chem, D-55122 Mainz, Germany.
C3 Complutense University of Madrid; Universidad de Malaga; Instituto de
   Investigacion Biomedica de Malaga y Plataforma en Nanomedicina (IBIMA);
   Johannes Gutenberg University of Mainz
RP de Fonseca, FR (corresponding author), Univ Complutense Madrid, Fac Psicol, Dept Psicobiol, Madrid, Spain.
EM fernando.rodriguez@ibima.eu; rgomezhe@psi.ucm.es
RI Rodríguez-Fonseca, Rolando Alberto/CAI-6743-2022; Orio,
   Laura/F-4827-2016; Suarez, Juan/JBJ-7320-2023; Lutz, Beat/AFK-6229-2022;
   Ramirez-Lopez, Maria Teresa/AAB-5705-2021; Gomez de Heras,
   Raquel/F-3484-2016; Alen, Francisco/I-3890-2017; Decara Del Olmo, Juan
   Manuel/I-1931-2015; Suarez, Juan/I-5188-2015
OI Ramirez-Lopez, Maria Teresa/0000-0002-3944-5264; Gomez de Heras,
   Raquel/0000-0002-5846-1059; Alen, Francisco/0000-0002-3847-3503; Blanco
   Velilla, Rosario Noemi/0000-0003-0265-6655; Orio,
   Laura/0000-0002-9614-4062; Decara Del Olmo, Juan
   Manuel/0000-0002-9868-015X; Suarez, Juan/0000-0001-5254-9802
FU Instituto de Salud Carlos III, Ministerio de Economia y Competitividad
   [PI13/0226, CP12/03109, PSI-2012-35388]; Red de Trastornos Adictivos
   [RD12/0028/0001]; CIBERobn; Consejeria de Economia, Innovacion y
   Ciencia; Junta de Andalucia; UE/ERDF [PI45403, CTS-8221, CTS-433];
   Consejeria de Salud, Junta de Andalucia [PI0232/2008, PI0029/2008,
   SAS111224]; German Research Foundation DFG [FOR926]; FPU predoctoral
   fellowship of the Spanish Ministerio de Educacion, Cultura y Deporte
   [AP-2009-0225]; National System of Health; ISCIII [CP14/00173]
FX This work was supported by the Instituto de Salud Carlos III, Ministerio
   de Economia y Competitividad (PI13/0226 to FR, CP12/03109 to JS and
   PSI-2012-35388 to RG), Red de Trastornos Adictivos (RD12/0028/0001 to
   FR), CIBERobn, Consejeria de Economia, Innovacion y Ciencia, Junta de
   Andalucia, UE/ERDF (PI45403, CTS-8221, CTS-433 to FR), Consejeria de
   Salud, Junta de Andalucia (PI0232/2008, PI0029/2008, and SAS111224 to IS
   and FR), and the German Research Foundation DFG (FOR926, project CP1 to
   BL). MT RL has been funded by a FPU predoctoral fellowship of the
   Spanish Ministerio de Educacion, Cultura y Deporte (AP-2009-0225); JS
   holds "Miguel Servet" research contract from the National System of
   Health, ISCIII (grant numbers CP14/00173). The authors also thank
   Claudia Schwitter for her help and support during lipid extraction and
   BCA analysis.
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NR 95
TC 33
Z9 35
U1 0
U2 23
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1662-5153
J9 FRONT BEHAV NEUROSCI
JI Front. Behav. Neurosci.
PD JAN 6
PY 2016
VL 9
AR 339
DI 10.3389/fnbeh.2015.00339
PG 15
WC Behavioral Sciences; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Behavioral Sciences; Neurosciences & Neurology
GA DA1SB
UT WOS:000367574700001
PM 26778987
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Noble, MIM
   Drake-Holland, AJ
   Vink, H
AF Noble, M. I. M.
   Drake-Holland, A. J.
   Vink, H.
TI Hypothesis: arterial glycocalyx dysfunction is the first step in the
   atherothrombotic process
SO QJM-AN INTERNATIONAL JOURNAL OF MEDICINE
LA English
DT Review
ID ENDOTHELIAL-CELL GLYCOCALYX; WALL SHEAR-STRESS; NITRIC-OXIDE;
   INSULIN-RESISTANCE; ILIAC ARTERY; FLOW; HYPERGLYCEMIA; VASOCONSTRICTION;
   IDENTIFICATION; DILATATION
AB We present evidence that the 0.5 m thick gel layer, lining the inner wall of healthy blood vessels, the glycocalyx, is the first line of defence against atherothrombotic disease. All blood vessel linings are coated with this gel, a highly negatively charged structure, rich in anionic sites mostly represented by the sialic acid moieties of glycoproteins and the sulphate and carboxyl groups of heparan-sulphate proteoglycans. Blood flow in arteries is associated with a shear stress at the glycocalyx, which signals the underlying endothelial cells to release nitric oxide (NO), an anti-atherogenic factor. Sites of low shear stress in the arterial tree are more susceptible to atheroma due to lack of NO generation through this mechanism, whereas exercise, by increasing blood flow and shear stress, is protective. We postulate that risk factors for atherothrombosis act by impairing glycocalyx function. That luminal hyperglycaemia causes glycocalyx dysfunction has already been shown; we postulate this to be the first step in the atherothrombotic process in patients with diabetes mellitus and metabolic syndrome (insulin resistance). There is also evidence of glycocalyx defects from exposure to oxidized low-density lipoprotein. We postulate that other risk factors will have a similar action on the glycocalyx as the initiating factor in the disease process, e.g. smoking, hyperlipidaemias and hyperhomocystenaemia. These predictions can now be tested in a large animal model of shear-stress-mediated arterial dilatation.
C1 [Noble, M. I. M.] Univ Aberdeen, Dept Med & Therapeut, Sch Med, Aberdeen AB25 2ZH, Scotland.
   [Drake-Holland, A. J.] Robert Gordon Univ, Sch Pharm & Life Sci, Aberdeen AB9 1FR, Scotland.
   [Vink, H.] Maastricht Univ, Dept Physiol, Maastricht, Netherlands.
C3 University of Aberdeen; Robert Gordon University; Maastricht University
RP Noble, MIM (corresponding author), Univ Aberdeen, Dept Med & Therapeut, Sch Med, Polwarth Bldg, Aberdeen AB25 2ZH, Scotland.
EM mimnoble@mac.com
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NR 32
TC 86
Z9 96
U1 0
U2 12
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1460-2725
EI 1460-2393
J9 QJM-INT J MED
JI QJM-An Int. J. Med.
PD JUL
PY 2008
VL 101
IS 7
BP 513
EP 518
DI 10.1093/qjmed/hcn024
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 319VC
UT WOS:000257191500002
PM 18319293
DA 2025-06-11
ER

PT J
AU Khateeb, S
   Albalawi, A
   Alkhedaide, A
AF Khateeb, Sahar
   Albalawi, Aishah
   Alkhedaide, Adel
TI Diosgenin Modulates Oxidative Stress and Inflammation in High-Fat
   Diet-Induced Obesity in Mice
SO DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
LA English
DT Article
DE obesity; diosgenin; adipose tissue; oxidative stress; proinflammatory
   cytokines
ID METABOLIC SYNDROME; OSTEOARTHRITIS; EXPRESSION; APOPTOSIS; CELLS; RISK
AB Introduction: Obesity is a chronic metabolic disorder that results in excessive energy accumulated in adipose tissue causing dysfunction of adipocytes, inflammation, and oxidative stress. Diosgenin (DG), a steroidal saponin produced by several plants, has been reported to have antioxidant activity. This study aimed to evaluate the effects of diosgenin on oxidative stress and inflammation in mice fed with a high-fat diet (HFD). Methods: Thirty adult male mice were divided into three groups including the control group, mice fed with a normal diet; the HFD group, mice fed with a high-fat diet for 6 weeks; and the HFD+DG group, mice fed with a high-fat diet and diosgenin daily for 6 weeks. Interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), malondialdehyde (MDA), and total antioxidant capacity (TAC) activities were evaluated. Histopathological changes in the adipose tissues have been investigated. Results: Data showed that diosgenin increased TAC activities with a concomitant decrease in MDA levels. As well, DG reduces the TNF and IL-6 levels. The histopathological changes in the adipose tissues due to high-fat consumption were restored upon DG supplementation. Conclusion: Our results suggested that diosgenin is a promising agent for regulating obesity by increasing the levels of antioxidants, modifying oxidative stress and pro-inflammatory cytokines, which might prevent the onset of many diseases.
C1 [Khateeb, Sahar] Fayoum Univ, Biochem Div, Dept Chem, Fac Sci, Al Fayyum, Egypt.
   [Albalawi, Aishah] Univ Tabuk, Fac Sci, Biol Dept, Tabuk, Saudi Arabia.
   [Alkhedaide, Adel] Taif Univ, Turabah Univ Coll, Dept Med Lab, POB 11099, Taif 21944, Saudi Arabia.
C3 Egyptian Knowledge Bank (EKB); Fayoum University; University of Tabuk;
   Taif University
RP Alkhedaide, A (corresponding author), Taif Univ, Turabah Univ Coll, Dept Med Lab, POB 11099, Taif 21944, Saudi Arabia.
EM a.khedaide@tu.edu.sa
RI Alkhedaide, Adel/GQA-5393-2022; Albalawi, Aishah/HSF-1391-2023; Khateeb,
   Sahar/HJH-1942-2023
OI Alkhedaide, Adel/0000-0002-5008-8421; Khateeb, Sahar/0000-0002-1524-7247
FU Taif University; Taif University, Taif, Saudi Arabia [TURSP-2020/104]
FX The authors greatly thank and acknowledge Taif University, for its
   support. This research has been supported by Taif University Research
   Supporting Project number (TURSP-2020/104) Taif University, Taif, Saudi
   Arabia.
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NR 37
TC 15
Z9 16
U1 0
U2 6
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-7007
J9 DIABET METAB SYND OB
JI Diabetes Metab. Syndr. Obes.
PY 2022
VL 15
BP 1589
EP 1596
DI 10.2147/DMSO.S355677
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 1S3YN
UT WOS:000803989900001
PM 35637860
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Mosesso, P
   Piane, M
   Pepe, G
   Cinelli, S
   Chessa, L
AF Mosesso, P.
   Piane, M.
   Pepe, G.
   Cinelli, S.
   Chessa, L.
TI Modulation of hypersensitivity to oxidative DNA damage in ATM defective
   cells induced by potassium bromate by inhibition of the Poly
   (ADP-ribose) polymerase (PARP)
SO MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
LA English
DT Article
DE Ataxia telangiectasia; ATM; Radiosensitivity; Oxidative stress; PARP;
   Potassium bromate
ID ATAXIA-TELANGIECTASIA; POLY(ADP-RIBOSE) POLYMERASE; STRESS; MUTATIONS;
   CANCER; TUMORS; ROLES; GENE
AB The ataxia telangiectasia mutated (ATM) protein is a pivotal multifunctional protein kinase predominantly in- volved in DNA damage response, as well as in maintaining overall functional integrity of the cells. Apart from playing its major role in regulating the cellular response to DNA damage, ATM, when mutated, can additionally determine oxidative stress, metabolic syndrome, mitochondrial dysfunction and neurodegeneration.
   In the present paper we aim to investigate the levels of oxidative stress potentially induced by the oxidizing rodent renal carcinogen KBrO3 in ATM-defective lymphoblastoid cell lines (Las) established from four classical AT patients (with different ATM mutations), one AT variant with reduced hypersensitivity to X rays, obligate AT heterozygotes and wild type intrafamilial control. A possible modulatory involvement of PARP in potentially induced oxidative stress is also evaluated following its inhibition with 3-aminobenzamide (3-AB).
   Treatments with KBrO3 clearly showed a marked hypersensitivity of the ATM-defective LCLs, including the AT variant. A marked and statistically significant reduction of KBrO3-induced chromosomal damage following inhibition of PARP by 3-AB, was observed in all AT LCLs, but not in those from the AT variant, AT heterozygotes and wild type intrafamilial control. This result is suggestive of a modulatory involvement of PARP in the hypersensitivity of ATM-defective cells to DNA oxidative damage.
C1 [Mosesso, P.; Pepe, G.] Univ Tuscia, Dipartimento Sci Ecol & Biol, Largo Univ Snc, I-01100 Viterbo, Italy.
   [Piane, M.; Chessa, L.] Sapienza Univ Roma, Dipartimento Med Clin & Mol, Fac Med & Psicol, Via Grottarossa 1035, I-00189 Rome, Italy.
   [Cinelli, S.] Res Toxicol Ctr, Via Tito Speri 12-14, I-00040 Pomezia, Roma, Italy.
C3 Tuscia University; Sapienza University Rome
RP Mosesso, P (corresponding author), Univ Tuscia, Dipartimento Sci Ecol & Biol, Largo Univ Snc, I-01100 Viterbo, Italy.
EM mosesso@unitus.it
RI Piane, Maria/ACZ-5462-2022
OI Mosesso, Pasquale/0000-0001-5648-1366; PIANE, Maria/0000-0001-8569-247X
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NR 29
TC 3
Z9 4
U1 0
U2 4
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1383-5718
EI 1879-3592
J9 MUTAT RES-GEN TOX EN
JI Mutat. Res. Genet. Toxicol. Environ. Mutagen.
PD DEC
PY 2018
VL 836
SI SI
BP 117
EP 123
DI 10.1016/j.mrgentox.2018.05.009
PN A
PG 7
WC Biotechnology & Applied Microbiology; Genetics & Heredity; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Genetics & Heredity; Toxicology
GA HC6TS
UT WOS:000451935200018
PM 30389154
DA 2025-06-11
ER

PT J
AU Sarna, LK
   Wu, N
   Wang, PQ
   Hwang, SY
   Siow, YL
   Karmin, O
AF Sarna, Lindsei K.
   Wu, Nan
   Wang, Pengqi
   Hwang, Sun-Young
   Siow, Yaw L.
   Karmin, O.
TI Folic acid supplementation attenuates high fat diet induced hepatic
   oxidative stress via regulation of NADPH oxidase
SO CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
LA English
DT Article
DE lipid peroxidation; NADPH oxidase; NF-kappa B; liver
ID SUPEROXIDE ANION PRODUCTION; KAPPA-B ACTIVATION; PROTEIN-KINASE-C;
   METABOLIC SYNDROME; FLAVOCYTOCHROME B(558); HOMOCYSTEINE LEVELS;
   INSULIN-RESISTANCE; NAD(P)H OXIDASE; OBESITY; LIVER
AB Diets high in saturated fat and cholesterol facilitate weight gain, a predisposing factor that contributes to the onset of obesity and metabolic disorders. Hepatic oxidative stress is commonly reported in various animal models of obesity and has been associated with enhanced expression of NADPH oxidase. We have previously reported several antioxidant mechanisms through which folic acid confers protection during hyperhomocysteinemia-induced oxidative stress. The objective of the present study was to investigate whether folic acid supplementation ameliorates high-fat diet induced oxidative stress in the liver, and to identify the underlying mechanisms. Male C57BL/6J mice were fed a control diet, a high-fat diet, or a high-fat diet supplemented with folic acid for 12 weeks. A high-fat diet led to increased body mass, hepatic lipid peroxidation, and liver injury. There was a significant increase in hepatic NADPH oxidase activity, which was associated with enhanced expression of several NADPH-oxidase subunits. Folic acid supplementation had a protective effect against high-fat diet induced hepatic oxidative stress and liver injury. Further analysis revealed that the antioxidant effect of folic acid was attributed, in part, to transcriptional regulation of NADPH oxidase. These results suggested that folic acid supplementation may be hepatoprotective from liver injury associated with a high-fat diet.
C1 [Sarna, Lindsei K.; Wu, Nan; Wang, Pengqi; Hwang, Sun-Young; Karmin, O.] St Boniface Gen Hosp, Res Ctr, Canadian Ctr Agri Food Res Hlth & Med CCARM, Integrat Biol Lab, Winnipeg, MB R2H 2A6, Canada.
   [Sarna, Lindsei K.; Wang, Pengqi; Hwang, Sun-Young; Karmin, O.] Univ Manitoba, Dept Anim Sci, Fac Agr & Food Sci, Winnipeg, MB R3T 2N2, Canada.
   [Wu, Nan; Siow, Yaw L.; Karmin, O.] Univ Manitoba, Dept Physiol, Fac Med, Winnipeg, MB R3E 0J9, Canada.
   [Siow, Yaw L.] Agr & Agri Food Canada, Ottawa, ON K1A 0C5, Canada.
C3 University of Manitoba; Saint Boniface Hospital; Children's Hospital
   Research Institute of Manitoba; University of Manitoba; University of
   Manitoba; Agriculture & Agri Food Canada
RP Karmin, O (corresponding author), St Boniface Gen Hosp, Res Ctr, Canadian Ctr Agri Food Res Hlth & Med CCARM, Integrat Biol Lab, 351 Tache Ave, Winnipeg, MB R2H 2A6, Canada.
EM karmino@sbrc.ca
RI Siow, Yaw/AGE-1903-2022
OI Siow, Yaw/0000-0001-6623-2881; O, Karmin/0000-0002-2163-9458
FU Heart & Stroke Foundation; Canadian Institutes of Health Research;
   Manitoba Health Research Council
FX This study was supported, in part, by grants from the Heart & Stroke
   Foundation and Canadian Institutes of Health Research. L.S. and N.W.
   were recipients of the Manitoba Health Research Council Studentship
   Award. We thank Q. Zhu and C. Sarna for their technical assistance.
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NR 43
TC 62
Z9 65
U1 0
U2 7
PU CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS
PI OTTAWA
PA 1200 MONTREAL ROAD, BUILDING M-55, OTTAWA, ON K1A 0R6, CANADA
SN 0008-4212
J9 CAN J PHYSIOL PHARM
JI Can. J. Physiol. Pharmacol.
PD FEB
PY 2012
VL 90
IS 2
BP 155
EP 165
DI 10.1139/Y11-124
PG 11
WC Pharmacology & Pharmacy; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Physiology
GA 897CC
UT WOS:000300617800004
PM 22309437
DA 2025-06-11
ER

PT J
AU Ghosh, AK
   Mau, T
   O'Brien, M
   Yung, R
AF Ghosh, Amiya Kumar
   Mau, Theresa
   O'Brien, Martin
   Yung, Raymond
TI Novel role of autophagy-associated Pik3c3 gene in gonadal white adipose
   tissue browning in aged C57/Bl6 male mice
SO AGING-US
LA English
DT Article
DE aging; adipose tissue; inflammation; ER-Stress; autophagy
ID ACID-BINDING PROTEIN; LIFE-SPAN; CALORIC RESTRICTION;
   INSULIN-RESISTANCE; APOLIPOPROTEIN-E; STRESS-RESPONSE; SELF-DIGESTION;
   DEFICIENT MICE; AP2; METABOLISM
AB Adipose tissue dysfunction is associated with inflammation, metabolic syndrome and other diseases in aging. Recent work has demonstrated that compromised autophagy activity in aging adipose tissue promotes ER stress responses, contributing to adipose tissue and systemic inflammation in aging. Phosphatidylinositol 3-kinase catalytic subunit type 3 (Pik3c3) is an 887 amino acid lipid kinase that regulates intracellular membrane trafficking and autophagy activity. To address the mechanistic link between autophagy and ER stress response in aging adipose tissue, we generated a line of adipose tissue-specific Pik3c3 knock out ((similar to)mutant mice) with the Fabp4 (Fatty acid binding protein 4) promoter driven Cre recombinase system. We found elevated ER stress response signaling with reduced autophagy activity without any significant change on adiposity or glucose tolerance in early life of Pik3c3 mutant mice. Interestingly, middle-and old-aged mutant mice exhibited improved glucose tolerance (GTT) and reduced adiposity compared to age and sex-matched littermates. In addition, adipose tissue-specific Pik3c3 mutants display reduced expression of adiposity-associated genes with the signature of adipose tissue browning phenotypes in old age. Overall, the results suggest that altered adipose tissue characteristics due to autophagy inhibition early in life has beneficial effects that promote adipose tissue browning and improves glucose tolerance in late-life.
C1 [Ghosh, Amiya Kumar; Mau, Theresa; O'Brien, Martin; Yung, Raymond] Univ Michigan, Dept Internal Med, Div Geriatr & Palliat Med, Ann Arbor, MI 48109 USA.
   [Yung, Raymond] VA Ann Arbor Hlth Syst, Geriatr Res Educ & Clin Care Ctr GRECC, Ann Arbor, MI 48105 USA.
C3 University of Michigan System; University of Michigan; Geriatric
   Research Education & Clinical Center; US Department of Veterans Affairs;
   Veterans Health Administration (VHA); VA Ann Arbor Healthcare System
RP Ghosh, AK; Yung, R (corresponding author), Univ Michigan, Dept Internal Med, Div Geriatr & Palliat Med, Ann Arbor, MI 48109 USA.; Yung, R (corresponding author), VA Ann Arbor Hlth Syst, Geriatr Res Educ & Clin Care Ctr GRECC, Ann Arbor, MI 48105 USA.
EM amiyag@umich.edu; ryung@umich.edu
RI Zambelli, Vanessa/C-2716-2013
OI Mau, Theresa/0000-0003-4278-6438
FU NIH [AG020628, AG028268, HL58984]; University of Michigan Claude D.
   Pepper Older American Independence Center [AG-024824]; Nathan Shock
   Center for the Basic Biology of Aging [AG-013283]; Aging Rodent Core
   [F034237]; Research Training in Experimental Immunology Training Grant
   [T32 AI007413]; US National Institute of Health [T32 AG000114];
   Geriatrics Research, Education and Clinical Care Center (GRECC) of the
   VA Ann Arbor Healthcare System; National Institute of Allergy and
   Infectious Diseases [T32AI007413] Funding Source: NIH RePORTER; National
   Institute of Environmental Health Sciences [P30ES017885] Funding Source:
   NIH RePORTER; National Institute on Aging [P30AG024824, T32AG000114]
   Funding Source: NIH RePORTER
FX This project has been funded in part by NIH grants AG020628 (RY),
   AG028268 (RY), HL58984 (RY), University of Michigan Claude D. Pepper
   Older American Independence Center (AG-024824 to AKG), Nathan Shock
   Center for the Basic Biology of Aging (AG-013283 to AKG), and Aging
   Rodent Core (F034237 to AKG), 'Research Training in Experimental
   Immunology Training Grant' (T32 AI007413 to TM), US National Institute
   of Health Grants (T32 AG000114 to TM) and Geriatrics Research, Education
   and Clinical Care Center (GRECC) of the VA Ann Arbor Healthcare System
   (RY). The content is solely the responsibility of the authors and does
   not necessarily represent the official views of the NIH.
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NR 40
TC 11
Z9 13
U1 0
U2 9
PU IMPACT JOURNALS LLC
PI ORCHARD PARK
PA 6666 E QUAKER ST, STE 1, ORCHARD PARK, NY 14127 USA
SN 1945-4589
J9 AGING-US
JI Aging-US
PD APR
PY 2018
VL 10
IS 4
BP 764
EP 774
DI 10.18632/aging.101426
PG 11
WC Cell Biology; Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Geriatrics & Gerontology
GA GH7AK
UT WOS:000433595400023
PM 29695642
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Koh, EH
   Park, JY
   Park, HS
   Jeon, MJ
   Ryu, JW
   Kim, M
   Kim, SY
   Kim, MS
   Kim, SW
   Park, IS
   Youn, JH
   Lee, KU
AF Koh, Eun Hee
   Park, Joong-Yeol
   Park, Hye-Sun
   Jeon, Min Jae
   Ryu, Je Won
   Kim, Mina
   Kim, Sun Young
   Kim, Min-Seon
   Kim, Seung-Whan
   Park, In Sun
   Youn, Jang Hyun
   Lee, Ki-Up
TI Essential role of mitochondrial function in adiponectin synthesis in
   adipocytes
SO DIABETES
LA English
DT Article; Proceedings Paper
CT 10th International Congress on Obesity
CY SEP 03-08, 2006
CL Sydney, AUSTRALIA
ID UNFOLDED PROTEIN RESPONSE; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   SKELETAL-MUSCLE; GENE-EXPRESSION; ADIPOSE-TISSUE;
   ANTIRETROVIRAL-THERAPY; OXIDATIVE STRESS; TNF-ALPHA; ER STRESS
AB OBJECTIVE-Adiponectin is an important adipocytokine that improves insulin action and reduces atherosclerotic processes. The plasma adiponectin level is paradoxically reduced in obese individuals, but the underlying mechanism is unknown. This study was undertaken to test the hypothesis that mitochondrial function is linked to adiponectin synthesis in adipocytes.
   RESEARCH DESIGN AND METHODS-We examined the effects of rosiglitazone and the measures that increase or decrease mitochondrial function on adiponectin synthesis. We also examined the molecular mechanism by which changes in mitochondrial function affect adiponectin synthesis.
   RESULTS-Adiponectin expression and mitochondrial content in adipose tissue were reduced in obese db/db mice, and these changes were reversed by the administration of rosiglitazone. In cultured adipocytes, induction of increased mitochondrial biogenesis (via adenoviral overexpression of nuclear respiratory factor-1) increased adiponectin synthesis, whereas impairment in mitochondrial function decreased it. Impaired mitochondrial function increased endoplasmic reticulum (ER) stress, and agents causing mitochondrial or ER stress reduced adiponectin transcription via activation of c-Jun NH2-terminal kinase (JNK) and consequent induction of activating transcription factor (ATF)3. Increased mitochondrial biogenesis reversed all of these changes.
   CONCLUSIONS-Mitochondrial function is linked to adiponectin synthesis in adipocytes, and mitochondrial dysfunction in adipose tissue may explain decreased plasma adiponectin levels in obesity. Impaired mitochondrial function activates a series of mechanisms involving ER stress, JNK, and ATF3 to decrease adiponectin synthesis.
C1 Univ Ulsan, Coll Med, Dept Internal Med, Seoul 138736, South Korea.
   Univ Ulsan, Coll Med, Asan Inst Life Sci, Seoul 138736, South Korea.
   Univ Ulsan, Coll Med, Dept Pharmacol, Seoul 138736, South Korea.
   Inha Univ, Coll Med, Dept Anat, Inchon, South Korea.
   Univ So Calif, Dept Physiol & Biophys, Keck Sch Med, Los Angeles, CA 90089 USA.
C3 University of Ulsan; University of Ulsan; University of Ulsan; Inha
   University; University of Southern California
RP Lee, KU (corresponding author), Univ Ulsan, Coll Med, Dept Internal Med, Seoul 138736, South Korea.
EM kulee@amc.seoul.kr
RI KIM, SIWOUK/KCY-8510-2024; Park, Jun/HPH-3570-2023; Kim, Jung
   Kyu/C-3271-2012
OI Kim, Seung-Whan/0000-0001-6983-0481
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NR 44
TC 229
Z9 253
U1 0
U2 23
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0012-1797
J9 DIABETES
JI Diabetes
PD DEC
PY 2007
VL 56
IS 12
BP 2973
EP 2981
DI 10.2337/db07-0510
PG 9
WC Endocrinology & Metabolism
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 237HS
UT WOS:000251365400019
PM 17827403
OA Bronze
DA 2025-06-11
ER

PT J
AU Irie, M
   Sohda, T
   Iwata, K
   Kunimoto, H
   Fukunaga, A
   Kuno, S
   Yotsumoto, K
   Sakurai, K
   Iwashita, H
   Hirano, G
   Ueda, SI
   Yokoyama, K
   Morihara, D
   Nishizawa, S
   Anan, A
   Takeyama, Y
   Sakamoto, M
   Shakado, S
   Sakisaka, S
AF Irie, M.
   Sohda, T.
   Iwata, K.
   Kunimoto, H.
   Fukunaga, A.
   Kuno, S.
   Yotsumoto, K.
   Sakurai, K.
   Iwashita, H.
   Hirano, G.
   Ueda, S. I.
   Yokoyama, K.
   Morihara, D.
   Nishizawa, S.
   Anan, A.
   Takeyama, Y.
   Sakamoto, M.
   Shakado, S.
   Sakisaka, S.
TI Levels of the Oxidative Stress Marker γ-Glutamyltranspeptidase at
   Different Stages of Nonalcoholic Fatty Liver Disease
SO JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
LA English
DT Article
DE NONALCOHOLIC FATTY LIVER DISEASE; NONALCOHOLIC STEATOHEPATITIS; FATTY
   LIVER; ALCOHOLIC LIVER DISEASE; OXIDATIVE STRESS;
   gamma-GLUTAMYLTRANSPEPTIDASE
ID NECROSIS-FACTOR-ALPHA; DNA-DAMAGE; INSULIN-RESISTANCE; METABOLIC
   SYNDROME; STEATOHEPATITIS; SERUM; GLUTAMYLTRANSFERASE; 8-HYDROXYGUANINE;
   PATHOGENESIS; ASSOCIATION
AB OBJECTIVES: This study investigated oxidative stress in the liver, by determining hepatic expression and serum levels of gamma-glutamyltranspeptidase (GGT) and 8-hydroxy-2'-deoxyguanosine (8-OHdG) in different stages of nonalcoholic fatty liver disease (NAFLD), and assessed whether GGT can differentiate between the various stages of NAFLD. METHODS: Expression of GGT and 8-OHdG was examined in biopsy specimens by immunohistochemistry, and serum GGT and 8-OHdG levels were measured by enzyme-linked immunosorbent assays in patients with simple fatty liver (n = 10), nonalcoholic steatohepatitis (NASH; n = 10) and, as a control, in alcoholic liver disease (ALD; n = 10). RESULTS: Hepatic tissue expression of GGT and 8-OHdG was seen in ALD, NASH and fatty liver patients. The percentage of hepatocytes positive for 8-OHdG expression and serum 8-OHdG levels was significantly higher in patients with NASH than simple fatty liver. Serum GGT levels were increased in all cases with ALD, NASH and fatty liver, and correlated significantly with serum levels of 8-OHdG in ALD and NASH, but not in simple fatty liver. CONCLUSIONS: Levels of GGT in fatty liver patients may compensate for mild oxidative stress by repressing 8-OHdG levels and preventing progression to NASH; however further oxidative stress leads to increased levels of 8-OHdG and the development of NASH.
C1 [Sakisaka, S.] Fukuoka Univ, Sch Med, Dept Gastroenterol, Fac Med,Jonan Ku, Fukuoka 8140180, Japan.
C3 Fukuoka University
RP Sakisaka, S (corresponding author), Fukuoka Univ, Sch Med, Dept Gastroenterol, Fac Med,Jonan Ku, 7-45-1 Nanakuma, Fukuoka 8140180, Japan.
EM sakisaka@fukuoka-u.ac.jp
OI TAKEYAMA, Yasuaki/0000-0001-7919-4407
CR Banderas DZ, 2012, EUR J GASTROENTEROL
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NR 32
TC 45
Z9 51
U1 0
U2 3
PU FIELD HOUSE PUBLISHING LLP
PI WORTHING
PA 6 SOMPTING AVENUE, WORTHING, BN14 8HN, ENGLAND
SN 0300-0605
J9 J INT MED RES
JI J. Int. Med. Res.
PD MAY-JUN
PY 2012
VL 40
IS 3
BP 924
EP 933
DI 10.1177/147323001204000311
PG 10
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA 978CR
UT WOS:000306718600011
PM 22906265
DA 2025-06-11
ER

PT J
AU Surace, T
   Capuzzi, E
   Caldiroli, A
   Ceresa, A
   Esposito, CM
   Tagliabue, I
   Capellazzi, M
   Legnani, F
   Di Paolo, M
   Cirella, L
   Quarantini, FZ
   Signorelli, MS
   Aguglia, E
   Clerici, M
   Buoli, M
   Auxilia, AM
AF Surace, Teresa
   Capuzzi, Enrico
   Caldiroli, Alice
   Ceresa, Alessandro
   Esposito, Cecilia Maria
   Tagliabue, Ilaria
   Capellazzi, Martina
   Legnani, Francesca
   Di Paolo, Martina
   Cirella, Luisa
   Quarantini, Francesco Zanelli
   Signorelli, Maria Salvina
   Aguglia, Eugenio
   Clerici, Massimo
   Buoli, Massimiliano
   Auxilia, Anna Maria
TI Which Clinical and Biochemical Parameters Are Associated with Lifetime
   Suicide Attempts in Bipolar Disorder?
SO DIAGNOSTICS
LA English
DT Article
DE bipolar disorder; suicide attempts; clinical features; biochemical
   markers
ID SUBSTANCE USE DISORDERS; METABOLIC SYNDROME; UNTREATED ILLNESS; OBESITY;
   RISK; STRESS; DURATION; BEHAVIOR; ANXIETY; DEFINITIONS
AB Introduction: Bipolar Disorder (BD) is a disabling condition with suicidal behavior as one of the most common adverse outcomes. The purpose of the present research is to investigate the relationship between lifetime suicide attempts and the clinical factors/biochemical parameters in a large sample of bipolar patients. Methods: A total of 561 patients, consecutively hospitalized for BD in Milan and Monza (Italy), were recruited. Data about the demographic and clinical variables, as well as the values of blood analyses, were collected. The groups identified according to the presence/absence of lifetime suicide attempts were compared using univariate analyses. Then, three preliminary binary logistic regressions and a final logistic regression model were performed to identify the clinical and biochemical parameters associated with lifetime suicide attempts in BD. Results: Lifetime suicide attempts in BD were predicted by a longer duration of untreated illness (DUI) (p = 0.005), absence of lifetime psychotic symptoms (p = 0.025), presence of poly-substance use disorders (p = 0.033), comorbidity with obesity (p = 0.022), a last mood episode of manic polarity (p = 0.044), and lower bilirubin serum levels (p = 0.002); higher total cholesterol serum levels showed a trend toward statistical significance (p = 0.058). Conclusions: BD patients with lifetime suicide attempts present unfavorable clinical features. Some specific biochemical characteristics of bipolar patients may represent potential markers of suicidal behavior and need to be better investigated to identify new targets of treatment in the framework of personalized medicine. These preliminary findings have to be confirmed by further studies in different clinical settings.
C1 [Surace, Teresa; Capuzzi, Enrico; Caldiroli, Alice; Clerici, Massimo] Azienda Socio Sanitaria Terr Monza, Dept Mental Hlth & Addict, Via GB,Pergolesi 33, I-20900 Monza, Italy.
   [Ceresa, Alessandro; Esposito, Cecilia Maria; Legnani, Francesca; Di Paolo, Martina; Quarantini, Francesco Zanelli; Buoli, Massimiliano] Fdn IRCCS Ca Granda Osped Maggiore Policlin, Dept Neurosci & Mental Hlth, Via F,Sforza 35, I-20122 Milan, Italy.
   [Tagliabue, Ilaria; Capellazzi, Martina; Clerici, Massimo; Auxilia, Anna Maria] Univ Milano Bicocca, Dept Med & Surg, Via Cadore 38, I-20900 Monza, Italy.
   [Cirella, Luisa] Fdn IRCCS Ca Granda Osped Maggiore Policlin, Healthcare Professionals Dept, I-20122 Milan, Italy.
   [Signorelli, Maria Salvina; Aguglia, Eugenio] Univ Catania, Dept Clin & Expt Med, Psychiat Unit, Via Santa Sofia 78, I-95123 Catania, Italy.
   [Buoli, Massimiliano] Univ Milan, Dept Pathophysiol & Transplantat, Via F Sforza 35, I-20122 Milan, Italy.
C3 IRCCS Ca Granda Ospedale Maggiore Policlinico; University of
   Milano-Bicocca; IRCCS Ca Granda Ospedale Maggiore Policlinico;
   University of Catania; University of Milan
RP Surace, T (corresponding author), Azienda Socio Sanitaria Terr Monza, Dept Mental Hlth & Addict, Via GB,Pergolesi 33, I-20900 Monza, Italy.
EM teresa.surace70@gmail.com
RI Capuzzi, Enrico/AEX-3621-2022; Esposito, Cecilia Maria/ITW-0989-2023;
   Auxilia, Anna Maria/MEO-2390-2025; Clerici, Massimo/U-3074-2019;
   Caldiroli, Alice/KIY-5948-2024; Buoli, Massimiliano/K-8509-2016;
   Salvina, Maria/E-6155-2010; Caldiroli, Alice/O-6633-2017
OI Buoli, Massimiliano/0000-0003-3359-3191; Auxilia, Anna
   Maria/0000-0002-8887-5818; Salvina, Maria/0000-0002-6941-9454;
   Caldiroli, Alice/0000-0002-8493-0779; aguglia,
   eugenio/0000-0003-2146-7737; CAPUZZI, ENRICO/0000-0001-8350-499X;
   Esposito, Cecilia Maria/0000-0002-4610-0686
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NR 88
TC 6
Z9 7
U1 0
U2 6
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2075-4418
J9 DIAGNOSTICS
JI Diagnostics
PD SEP
PY 2022
VL 12
IS 9
AR 2215
DI 10.3390/diagnostics12092215
PG 18
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 4Q8DE
UT WOS:000856306600001
PM 36140615
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Soare, A
   Weiss, EP
   Holloszy, JO
   Fontana, L
AF Soare, Andreea
   Weiss, Edward P.
   Holloszy, John O.
   Fontana, Luigi
TI Multiple dietary supplements do not affect metabolic and cardiovascular
   health
SO AGING-US
LA English
DT Article
DE supplements; endothelial function; arterial stiffness; inflammation;
   oxidative stress
ID FATTY-ACID OXIDATION; C-REACTIVE PROTEIN; ARTERIAL STIFFNESS;
   NECROSIS-FACTOR; PULSE PRESSURE; OLDER-ADULTS; IMPROVES; INHIBITION;
   QUERCETIN; EXTRACT
AB Dietary supplements are widely used for health purposes. However, little is known about the metabolic and cardiovascular effects of combinations of popular over-the-counter supplements, each of which has been shown to have anti-oxidant, anti-inflammatory and pro-longevity properties in cell culture or animal studies. This study was a 6-month randomized, single-blind controlled trial, in which 56 non-obese (BMI 21.0-29.9 kg/m(2)) men and women, aged 38 to 55 yr, were assigned to a dietary supplement (SUP) group or control (CON) group, with a 6-month follow-up. The SUP group took 10 dietary supplements each day (100 mg of resveratrol, a complex of 800 mg each of green, black, and white tea extract, 250 mg of pomegranate extract, 650 mg of quercetin, 500 mg of acetyl-l-carnitine, 600 mg of lipoic acid, 900 mg of curcumin, 1 g of sesamin, 1.7 g of cinnamon bark extract, and 1.0 g fish oil). Both the SUP and CON groups took a daily multivitamin/mineral supplement. The main outcome measures were arterial stiffness, endothelial function, biomarkers of inflammation and oxidative stress, and cardiometabolic risk factors. Twenty-four weeks of daily supplementation with 10 dietary supplements did not affect arterial stiffness or endothelial function in nonobese individuals. These compounds also did not alter body fat measured by DEXA, blood pressure, plasma lipids, glucose, insulin, IGF-1, and markers of inflammation and oxidative stress. In summary, supplementation with a combination of popular dietary supplements has no cardiovascular or metabolic effects in non-obese relatively healthy individuals.
C1 [Soare, Andreea; Weiss, Edward P.; Holloszy, John O.; Fontana, Luigi] Washington Univ, Sch Med, Dept Med, Div Geriatr & Nutr Sci, St Louis, MO 63130 USA.
   [Soare, Andreea] Dept Endocrinol & Diabet, Rome, Italy.
   [Weiss, Edward P.] St Louis Univ, Dept Nutr & Dietet, St Louis, MO 63130 USA.
   [Fontana, Luigi] Univ Salerno, Sch Med, Dept Med, I-84100 Salerno, Italy.
   [Fontana, Luigi] CEINGE Biotecnol Avanzate, Naples, Italy.
C3 Washington University (WUSTL); Saint Louis University; University of
   Salerno; CEINGE Biotecnologie Avanzate
RP Fontana, L (corresponding author), Washington Univ, Sch Med, Dept Med, Div Geriatr & Nutr Sci, St Louis, MO 63130 USA.
EM fontana@dom.wustl.edu
RI Fontana, Luigi/K-4773-2013; Weiss, Edward/P-1682-2017
OI Fontana, Luigi/0000-0001-8500-5537
FU NIDDK NIH HHS [P30 DK056341, P30 DK020579] Funding Source: Medline
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NR 39
TC 42
Z9 48
U1 0
U2 22
PU IMPACT JOURNALS LLC
PI ORCHARD PARK
PA 6666 E QUAKER ST, STE 1, ORCHARD PARK, NY 14127 USA
SN 1945-4589
J9 AGING-US
JI Aging-US
PD FEB
PY 2014
VL 6
IS 2
BP 149
EP 157
PG 9
WC Cell Biology; Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Geriatrics & Gerontology
GA AC7IQ
UT WOS:000332701900008
PM 24659610
DA 2025-06-11
ER

PT J
AU Turgeon, RD
   Pearson, GJ
   Graham, MM
AF Turgeon, Ricky D.
   Pearson, Glen J.
   Graham, Michelle M.
TI Pharmacologic Treatment of Patients With Myocardial Ischemia With No
   Obstructive Coronary Artery Disease
SO AMERICAN JOURNAL OF CARDIOLOGY
LA English
DT Review
ID CARDIAC SYNDROME-X; CONVERTING ENZYME-INHIBITION; IMPROVES ENDOTHELIAL
   FUNCTION; CALCIUM-CHANNEL BLOCKER; EXERCISE-INDUCED ANGINA; ST SEGMENT
   DEPRESSION; MICROVASCULAR DYSFUNCTION; DOUBLE-BLIND; POSTMENOPAUSAL
   WOMEN; FLOW RESERVE
AB Half of women and 1/3 of men with angina and ischemia on stress testing have ischemia with no obstructive coronary artery disease (INOCA). These patients have quality of life (QoL) impairment comparable with patients with obstructive coronary artery disease. Clinicians generally treat INOCA with traditional antianginal agents despite previous studies demonstrating variable response to these medications. We performed a systematic review to evaluate the efficacy and safety of available pharmacologic therapies for INOCA. We systematically searched the Cochrane Central Register of Controlled Trials, Embase, MEDLINE, and the World Health Organization International Clinical Trials Registry Platform in July 2017 for randomized controlled trials (RCTs) evaluating pharmacologic agents for INOCA. The primary outcome of interest was QoL. Secondary outcomes included subjective and objective efficacy measures and safety outcomes. We included 35 RCTs from 333 identified studies. Interventions that improved QoL with moderate-quality evidence included angiotensin-converting enzyme (ACE) inhibitor ( statin) and ranolazine. Low-to very -low-quality evidence also suggests that ACE inhibitors, (3 blockers, calcium-channel blockers, nicorandil, ranolazine, and statins may decrease angina frequency and delay ischemia on stress testing. Other interventions, most notably nitrates, did not significantly improve any outcome. In conclusion, evidence for pharmacologic treatment of INOCA is generally poor, and higher-quality RCTs using a standardized definition of INOCA are needed. Moderate-quality evidence suggests that ACE inhibitors and ranolazine improve QoL. Other interventions had low-quality evidence or no evidence of efficacy. (C) 2018 Elsevier Inc. All rights reserved.
C1 [Turgeon, Ricky D.; Pearson, Glen J.; Graham, Michelle M.] Univ Alberta, Dept Med, Div Cardiol, Edmonton, AB, Canada.
C3 University of Alberta
RP Turgeon, RD (corresponding author), Univ Alberta, Dept Med, Div Cardiol, Edmonton, AB, Canada.
EM rturgeon@ualberta.ca
RI Pearson, Glen/ABF-8219-2020; Turgeon, Ricky/V-3522-2019
OI Turgeon, Ricky/0000-0002-3967-1528; Pearson, Glen/0000-0003-3281-7915;
   Graham, Michelle/0000-0003-0708-7957
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NR 48
TC 13
Z9 14
U1 0
U2 13
PU EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
PI BRIDGEWATER
PA 685 ROUTE 202-206 STE 3, BRIDGEWATER, NJ 08807 USA
SN 0002-9149
EI 1879-1913
J9 AM J CARDIOL
JI Am. J. Cardiol.
PD APR 1
PY 2018
VL 121
IS 7
BP 888
EP 895
DI 10.1016/j.amjcard.2017.12.025
PG 8
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA GC1DG
UT WOS:000429516200017
PM 29394999
DA 2025-06-11
ER

PT J
AU Oudot, A
   Behr-Roussel, D
   Compagnie, S
   Caisey, S
   Le Coz, O
   Gorny, D
   Alexandre, L
   Giuliano, F
AF Oudot, A.
   Behr-Roussel, D.
   Compagnie, S.
   Caisey, S.
   Le Coz, O.
   Gorny, D.
   Alexandre, L.
   Giuliano, F.
TI Endothelial Dysfunction in Insulin-Resistant Rats is Associated with
   Oxidative Stress and COX Pathway Dysregulation
SO PHYSIOLOGICAL RESEARCH
LA English
DT Article
DE Endothelial dysfunction; Insulin resistance; Oxidative stress;
   Cyclo-oxygenase
ID ORAL GLUCOSE-TOLERANCE; NITRIC-OXIDE; DEPENDENT CONTRACTIONS; METABOLIC
   SYNDROME; BLOOD-FLOW; FRUCTOSE; HYPERTENSION; ACETYLCHOLINE;
   ANGIOTENSIN; RELAXATION
AB Because insulin resistance is inevitably associated with cardiovascular complications, there is a need to further investigate the potential involvement of oxidative stress and the cyclo-oxygenase (COX) pathway in the vascular modifications associated to this pathological context. Endothelial function was evaluated in control and fructose-fed rats (FFR) by i) in vitro study of endothelium-dependent and -independent relaxations of aortic rings, and ii) in vivo telemetric evaluation of pressor response to norepinephrine. After 9 weeks of diet, FFR displayed hypertriglyceridemia, hyperinsulinemia and exaggerated response to glucose overload. Aortic rings from control rats and FFR exhibited comparable endothelium-dependent relaxations to Ach. In the presence of indomethacin, relaxations were significantly reduced. FFR showed exaggerated pressor responses to norepinephrine that were abolished with indomethacin. Urinary nitrites/nitrates, 8-isoprostanes and thromboxane B-2 excretion levels were markedly enhanced in FFR, whereas the plasma levels of 6-keto prostaglandin F-1 alpha were unchanged. In conclusion, fructose overload in rats induced hypertriglyceridemia and insulin resistance associated with an enhanced oxidative stress. This was associated with COX pathway dysregulation which could be one of the contributors to subsequent vascular dysfunction. Consequently, reduction of oxidative stress and regulation of the COX pathway could represent new potential therapeutic strategies to limit vascular dysfunction and subsequent cardiovascular complications associated with insulin resistance.
C1 [Giuliano, F.] Hop Raymond Poincare, AP HP, Neuro Uro Androl Unit, Dept Phys Med & Rehabil, 104 Bd Raymond, F-92380 Garches, France.
   [Oudot, A.; Behr-Roussel, D.; Compagnie, S.; Caisey, S.; Le Coz, O.; Gorny, D.; Alexandre, L.; Giuliano, F.] Pelvipharm, Orsay, France.
C3 Assistance Publique Hopitaux Paris (APHP); Hopital Universitaire
   Raymond-Poincare - APHP
RP Giuliano, F (corresponding author), Hop Raymond Poincare, AP HP, Neuro Uro Androl Unit, Dept Phys Med & Rehabil, 104 Bd Raymond, F-92380 Garches, France.
EM giuliano@cyber-sante.org
RI Behr-Roussel, Delphine/AAT-3626-2020
OI OUDOT, Alexandra/0000-0002-1267-0293
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NR 52
TC 17
Z9 19
U1 1
U2 1
PU ACAD SCIENCES CZECH REPUBLIC, INST PHYSIOLOGY
PI PRAGUE 4
PA VIDENSKA 1083, PRAGUE 4 142 20, CZECH REPUBLIC
SN 0862-8408
EI 1802-9973
J9 PHYSIOL RES
JI Physiol. Res.
PY 2009
VL 58
IS 4
BP 499
EP 509
DI 10.33549/physiolres.931583
PG 11
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA 507ME
UT WOS:000270857000004
PM 18657000
OA gold
DA 2025-06-11
ER

PT J
AU Scheuner, D
   Kaufman, RJ
AF Scheuner, Donalyn
   Kaufman, Randal J.
TI The unfolded protein response:: A pathway that links insulin demand with
   β-cell failure and diabetes
SO ENDOCRINE REVIEWS
LA English
DT Review
ID ENDOPLASMIC-RETICULUM STRESS; ISLET AMYLOID POLYPEPTIDE;
   WOLCOTT-RALLISON-SYNDROME; MESSENGER-RNA TRANSLATION; CHRONIC OXIDATIVE
   STRESS; DISULFIDE BOND FORMATION; INDUCED GENE-EXPRESSION; REGULATING
   KINASE 1; ER STRESS; TRANSCRIPTION FACTOR
AB The endoplasmic reticulum (ER) is the entry site into the secretory pathway for newly synthesized proteins destined for the cell surface or released into the extracellular milieu. The study of protein folding and trafficking within the ER is an extremely active area of research that has provided novel insights into many disease processes. Cells have evolved mechanisms to modulate the capacity and quality of the ER protein-folding machinery to prevent the accumulation of unfolded or misfolded proteins. These signaling pathways are collectively termed the unfolded protein response (UPR). The UPR sensors signal a transcriptional response to expand the ER folding capacity, increase degredation of malfolded proteins, and limit the rate of mRNA translation to reduce the client protein load. Recent genetic and biochemical evidence in both humans and mice supports a requirement for the UPR to preserve ER homeostasis and prevent the beta-cell failure that maybe fundamental in the etiology of diabetes. Chronic or over-whelming ER stress stimuli associated with metabolic syndrome can disrupt protein folding in the ER, reduce insulin secretion, invoke oxidative stress, and activate cell death pathways. Therapeutic interventions to prevent polypeptide-misfolding, oxidative damage, and/or UPR-induced cell death have the potential to improve beta-cell function and/or survival in the treatment of diabetes.
C1 [Scheuner, Donalyn; Kaufman, Randal J.] Univ Michigan, Med Ctr, Dept Biol Chem, Ann Arbor, MI 48109 USA.
   [Kaufman, Randal J.] Univ Michigan, Med Ctr, Dept Internal Med, Ann Arbor, MI 48109 USA.
   [Kaufman, Randal J.] Univ Michigan, Med Ctr, Howard Hughes Med Inst, Ann Arbor, MI 48109 USA.
C3 University of Michigan System; University of Michigan; University of
   Michigan System; University of Michigan; Howard Hughes Medical
   Institute; University of Michigan System; University of Michigan
RP Kaufman, RJ (corresponding author), Univ Michigan, Med Ctr, Dept Biol Chem, Ann Arbor, MI 48109 USA.
EM scheuner@umich.edu; kaufmanr@umich.edu
RI Kaufman, Randal/LGY-4753-2024
FU Howard Hughes Medical Institute Funding Source: Medline; NHLBI NIH HHS
   [HL052173, R01 HL052173] Funding Source: Medline; NIDDK NIH HHS
   [DK42395] Funding Source: Medline
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NR 176
TC 455
Z9 526
U1 0
U2 43
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0163-769X
EI 1945-7189
J9 ENDOCR REV
JI Endocr. Rev.
PD MAY
PY 2008
VL 29
IS 3
BP 317
EP 333
DI 10.1210/er.2007-0039
PG 17
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 301BI
UT WOS:000255871000006
PM 18436705
OA Green Published
DA 2025-06-11
ER

PT J
AU Fenech, AL
   Soriano, EC
   Asok, A
   Siegel, SD
   Morreale, M
   Brownlee, HA
   Laurenceau, JP
AF Fenech, Alyssa L.
   Soriano, Emily C.
   Asok, Arun
   Siegel, Scott D.
   Morreale, Michael
   Brownlee, Hannah A.
   Laurenceau, Jean-Philippe
TI Fear of cancer recurrence and change in hair cortisol concentrations in
   partners of breast cancer survivors
SO JOURNAL OF CANCER SURVIVORSHIP
LA English
DT Article; Early Access
DE Breast cancer; Fear of cancer recurrence; Hair cortisol; Intimate
   partners; Change models
ID COPING STRATEGIES; CHRONIC STRESS; PSYCHOLOGICAL DISTRESS; METABOLIC
   SYNDROME; SALIVARY CORTISOL; CAREGIVERS; ANXIETY; PREDICTORS; DIAGNOSIS;
   FATIGUE
AB PurposePartners of breast cancer (BC) survivors report high rates of psychological distress including fear of cancer recurrence (FCR). Research suggests that partners may have poorer physical health outcomes than the general population, but little research has examined the physiological biomarkers by which distress may impact partner health outcomes. The current study examined the associations between FCR and changes in hair cortisol among BC partners.MethodsMale partners (N = 73) of early-stage BC survivors provided hair samples during two visits, one after completion of survivors' adjuvant treatment (T1) and again 6 months later (T2). Two subscales from the Fear of Cancer Recurrence Inventory and one subscale from the Concerns about Recurrence Scale comprised a latent FCR factor at T1. A latent change score model was used to examine change in cortisol as a function of FCR.ResultsPartners were on average 59.65 years of age (SD = 10.53) and non-Hispanic White (83%). Latent FCR at T1 was positively associated (b = 0.08, SE = 0.03, p = .004, standardized beta = .45) with change in latent hair cortisol from T1 to T2.ConclusionsResults indicated that greater FCR was associated with increases in hair cortisol in the months following adjuvant treatment. This is one of the first studies to examine the physiological correlates of FCR that may impact health outcomes in BC partners.Implications for Cancer Survivors.Findings highlight the need for further research into the relationship between FCR and its physiological consequences. Interventions to address partner FCR are needed and may aid in improving downstream physical health outcomes.
C1 [Fenech, Alyssa L.; Morreale, Michael; Brownlee, Hannah A.; Laurenceau, Jean-Philippe] Univ Delaware, Dept Psychol & Brain Sci, 108 Wolf Hall, Newark, DE 19716 USA.
   [Soriano, Emily C.] Scripps Whittier Diabet Inst, San Diego, CA USA.
   [Asok, Arun] Alien Therapeut Inc, Philadelphia, PA USA.
   [Siegel, Scott D.; Laurenceau, Jean-Philippe] Helen F Graham Canc Ctr & Res Inst Christiana Care, Newark, DE 19713 USA.
C3 University of Delaware
RP Fenech, AL; Laurenceau, JP (corresponding author), Univ Delaware, Dept Psychol & Brain Sci, 108 Wolf Hall, Newark, DE 19716 USA.; Laurenceau, JP (corresponding author), Helen F Graham Canc Ctr & Res Inst Christiana Care, Newark, DE 19713 USA.
EM afenech@udel.edu; jlaurenc@udel.edu
RI Soriano, Emily/J-4312-2019; Laurenceau, Jean-Philippe/AAZ-8506-2020;
   Fenech, Alyssa/AAC-9980-2022
FU National Cancer Institute [R21CA171921]
FX This study was partially supported by a grant funded by the National
   Cancer Institute (R21CA171921; PI: Laurenceau).
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NR 56
TC 0
Z9 0
U1 0
U2 7
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1932-2259
EI 1932-2267
J9 J CANCER SURVIV
JI J. Cancer Surviv.-Res. Pract.
PD 2024 JUL 2
PY 2024
DI 10.1007/s11764-024-01631-1
EA JUL 2024
PG 9
WC Oncology; Social Sciences, Biomedical
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Oncology; Biomedical Social Sciences
GA XJ0H6
UT WOS:001261194300001
PM 38954249
OA hybrid
DA 2025-06-11
ER

PT J
AU McCarty, MF
   Assanga, SI
   Lujan, LL
AF McCarty, Mark F.
   Assanga, Simon Iloki
   Lujan, Lidianys Lewis
TI Age-adjusted mortality from pancreatic cancer increased NINE-FOLD in
   japan from 1950 to 1995-Was a low-protein quasi-vegan diet a key factor
   in their former low risk?
SO MEDICAL HYPOTHESES
LA English
DT Article
DE Pancreatic cancer; Acinar cells; ER stress; GCN2; FGF21; Vegan diet
ID ENDOPLASMIC-RETICULUM STRESS; ESTROGEN-RECEPTOR BETA; BODY-MASS INDEX;
   NF-KAPPA-B; NADPH OXIDASE; SPIRULINA-PLATENSIS; COLORECTAL-CANCER;
   PHYSICAL-ACTIVITY; PROSTATE-CANCER; FATTY-ACIDS
AB During the last half of the twentieth century, age-adjusted mortality from pancreatic cancer in Japan rose about nine-fold in both sexes. Well-characterized risk factors such as smoking, obesity/metabolic syndrome, and heavy alcohol use appear to explain only a modest part of this rise. It is proposed that a diet relatively low in protein, and particularly low in animal protein, was a key determinant of the low risk for pancreatic cancer in midcentury Japan. It is further proposed that pancreatic acinar cells, owing to their extraordinarily high rate of protein synthesis, are at high risk for ER stress; that such stress plays a fundamental role in the induction of most pancreatic cancers; and that low-protein diets help to offset such stress by modulating activities of the kinases GCN2 and mTORC1 while increasing autocrine and systemic production of fibroblast growth factor 21. This model appears to clarify the role of various risk factors and protective factors in pancreatic cancer induction. A vegan or quasi-vegan low-protein diet may have broader potential for decreasing risk for a range of common ?Western? cancers.
C1 [McCarty, Mark F.] Catalyt Longev Fdn, 811 B Nahant Ct, San Diego, CA 92109 USA.
   [Assanga, Simon Iloki; Lujan, Lidianys Lewis] Univ Sonora, Dept Res & Postgrad Food, Hermosillo, Sonora, Mexico.
C3 Universidad de Sonora
RP McCarty, MF (corresponding author), Catalyt Longev Fdn, 811 B Nahant Ct, San Diego, CA 92109 USA.
EM markfmccarty@gmail.com
RI Lewis, Lidianys/ISV-3783-2023; ILOKI ASSANGA, SIMON
   BERNARD/GNP-3218-2022
OI ILOKI ASSANGA, SIMON BERNARD/0000-0002-2058-5881
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NR 137
TC 1
Z9 1
U1 0
U2 16
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0306-9877
EI 1532-2777
J9 MED HYPOTHESES
JI Med. Hypotheses
PD APR
PY 2021
VL 149
AR 110518
DI 10.1016/j.mehy.2021.110518
PG 6
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA RG6FS
UT WOS:000635632300011
PM 33582316
DA 2025-06-11
ER

PT J
AU Carpino, G
   Pastori, D
   Baratta, F
   Overi, D
   Labbadia, G
   Polimeni, L
   Di Costanzo, A
   Pannitteri, G
   Carnevale, R
   Del Ben, M
   Arca, M
   Violi, F
   Angelico, F
   Gaudio, E
AF Carpino, Guido
   Pastori, Daniele
   Baratta, Francesco
   Overi, Diletta
   Labbadia, Giancarlo
   Polimeni, Licia
   Di Costanzo, Alessia
   Pannitteri, Gaetano
   Carnevale, Roberto
   Del Ben, Maria
   Arca, Marcello
   Violi, Francesco
   Angelico, Francesco
   Gaudio, Eugenio
TI PNPLA3 variant and portal/periportal histological pattern in patients
   with biopsy-proven non-alcoholic fatty liver disease: a possible role
   for oxidative stress
SO SCIENTIFIC REPORTS
LA English
DT Article
ID HEPATIC STELLATE CELLS; 3 GENE PNPLA3; METABOLIC SYNDROME; NADPH
   OXIDASES; FIBROSIS; ASSOCIATION; SEVERITY; RISK; STEATOHEPATITIS;
   REGENERATION
AB Pathogenesis of non-alcoholic fatty liver disease (NAFLD) is influenced by predisposing genetic variations, dysmetabolism, systemic oxidative stress, and local cellular and molecular cross-talks. Patatin-like phospholipase domain containing 3 (PNPLA3) gene I148M variant is a known determinant of NAFLD. Aims were to evaluate whether PNPLA3 I148M variant was associated with a specific histological pattern, hepatic stem/progenitor cell (HpSC) niche activation and serum oxidative stress markers. Liver biopsies were obtained from 54 NAFLD patients. The activation of HpSC compartment was evaluated by the extension of ductular reaction (DR); hepatic stellate cells, myofibroblasts (MFs), and macrophages were evaluated by immunohistochemistry. Systemic oxidative stress was assessed measuring serum levels of soluble NOX2-derived peptide (sNOX2-dp) and 8-isoprostaglandin F-2 alpha (8-iso-PGF(2 alpha)). PNPLA3 carriers showed higher steatosis, portal inflammation and HpSC niche activation compared to wild-type patients. DR was correlated with NAFLD activity score (NAS) and fibrosis score. Serum 8-iso-PGF2a were significantly higher in I148M carriers compared to non-carriers and were correlated with DR and portal inflammation. sNox2-dp was correlated with NAS and with HpSC niche activation. In conclusion, NAFLD patients carrying PNPLA3 I148M are characterized by a prominent activation of HpSC niche which is associated with a more aggressive histological pattern (portal fibrogenesis) and increased oxidative stress.
EM francesco.angelico@uniroma1.it
RI Carpino, Guido/AAB-9692-2019; Overi, Diletta/AAP-3632-2021; Del Ben,
   Maria/AAE-7603-2020; Angelico, Francesco/AAB-6585-2020; ARCA,
   Marcello/AAC-3883-2022; Carnevale, Roberto/JMC-1138-2023; pastori,
   daniele/J-7087-2016
OI CARPINO, Guido/0000-0001-8570-2519; Baratta,
   Francesco/0000-0003-1708-272X; ARCA, Marcello/0000-0003-3786-0883;
   Overi, Diletta/0000-0003-3561-8903; pastori, daniele/0000-0001-6357-5213
FU FIRB [RBAP10Z7FS_001]; PRIN [2009 x 84L84_001]; Sapienza University of
   Rome
FX We thank nurse Daniela Salzano for her skillful collaborations. E.
   Gaudio was supported by research project grant from Sapienza University
   of Rome, FIRB grant # RBAP10Z7FS_001 and by PRIN grant # 2009 x
   84L84_001.
CR [Anonymous], BIOCH BIOPHYSICA ACT
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NR 49
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PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
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JI Sci Rep
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PY 2017
VL 7
AR 15756
DI 10.1038/s41598-017-15943-z
PG 12
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA FN0HJ
UT WOS:000415658600001
PM 29150621
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Ghosh, P
AF Ghosh, Pradipta
TI The stress polarity pathway: AMPK 'GIV'-es protection against metabolic
   insults
SO AGING-US
LA English
DT Article
DE LKB1; AMP-kinase; epithelial tight junctions; gut barrier; metabolic
   syndrome; heterotrimeric G proteins; energetic stress
ID ACTIVATED PROTEIN-KINASE; CYTOSOLIC 3-HYDROXY-3-METHYLGLUTARYL COENZYME;
   INTESTINAL EPITHELIAL BARRIER; IRRITABLE-BOWEL-SYNDROME; CACO-2 CELL
   MONOLAYERS; CHRONIC HEART-FAILURE; GUT MICROBIOTA; RAT-LIVER; TIGHT
   JUNCTIONS; AKKERMANSIA-MUCINIPHILA
AB Loss of cell polarity impairs organ development and function; it can also serve as one of the first triggers for oncogenesis. In 2006-2007 two groups simultaneously reported the existence of a special pathway for maintaining epithelial polarity in the face of environmental stressors. In this pathway, AMPK, a key sensor of metabolic stress stabilizes tight junctions, preserves cell polarity, and thereby, maintains epithelial barrier functions. Accumulating evidence since has shown that pharmacologic activation of AMPK by Metformin protects the epithelial barrier against multiple environmental and pathological stressful states and suppresses tumorigenesis. How AMPK protects the epithelium remained unknown until recently Aznar et al. identified GIV/Girdin as a novel effector of AMPK at the cell-cell junctions; phosphorylation of GIV at a single site by AMPK appears to be both necessary and sufficient for strengthening tight junctions and preserving cell polarity and epithelial barrier function in the face of energetic stress. Here we review the fundamentals of this specialized signaling pathway that buttresses cell-cell junctions against stress-induced collapse and discuss its pathophysiologic relevance in the context of a variety of diseases, including cancers, diabetes, aging, and the growing list of beneficial effects of the AMPK-activator, Metformin.
C1 [Ghosh, Pradipta] Univ Calif, Dept Med & Cellular & Mol Med, San Diego, CA 92093 USA.
C3 University of California System; University of California San Diego
RP Ghosh, P (corresponding author), Univ Calif, Dept Med & Cellular & Mol Med, San Diego, CA 92093 USA.
EM prghosh@ucsd.edu
FU NIH [R01CA160911, R01CA100768, DK099226]
FX This work was funded by NIH (R01CA160911, R01CA100768 and DK099226) to
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NR 105
TC 9
Z9 12
U1 0
U2 8
PU IMPACT JOURNALS LLC
PI ORCHARD PARK
PA 6666 E QUAKER ST, STE 1, ORCHARD PARK, NY 14127 USA
SN 1945-4589
J9 AGING-US
JI Aging-US
PD FEB
PY 2017
VL 9
IS 2
BP 303
EP 314
DI 10.18632/aging.101179
PG 12
WC Cell Biology; Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Geriatrics & Gerontology
GA EO7TH
UT WOS:000396892500004
PM 28209925
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Udi, S
   Hinden, L
   Ahmad, M
   Drori, A
   Iyer, MR
   Cinar, R
   Herman-Edelstein, M
   Tam, J
AF Udi, Shiran
   Hinden, Liad
   Ahmad, Majdoleen
   Drori, Adi
   Iyer, Malliga R.
   Cinar, Resat
   Herman-Edelstein, Michal
   Tam, Joseph
TI Dual inhibition of cannabinoid CB1 receptor and inducible NOS
   attenuates obesity-induced chronic kidney disease
SO BRITISH JOURNAL OF PHARMACOLOGY
LA English
DT Article
ID NITRIC-OXIDE SYNTHASE; CARDIOMETABOLIC RISK; GLOMERULAR HYPERFILTRATION;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; CONCISE GUIDE; ADIPONECTIN;
   EXPRESSION; BLOCKADE; DIET
AB Background and Purpose Obesity, an important risk factor for developing chronic kidney disease (CKD), affects the kidneys by two main molecular signalling pathways: the endocannabinoid/CB1 receptor system, whose activation in obesity promotes renal inflammation, fibrosis, and injury, and the inducible NOS (iNOS), which generates ROS resulting in oxidative stress. Hence, a compound that inhibits both peripheral CB1 receptors and iNOS may serve as an effective therapeutic agent against obesity-induced CKD. Experimental Approach Here, we describe the effect of a novel peripherally restricted, orally bioavailable dual CB1 receptor/iNOS antagonist, MRI-1867 (3 mg center dot kg(-1)), in ameliorating obesity-induced CKD, and compared its metabolic and renal efficacies to a stand-alone peripheral CB1 receptor antagonist (JD5037; 3 mg center dot kg(-1)), iNOS antagonist (1400W; 10 mg center dot kg(-1)), and pair feeding. Mice with high-fat diet-induced obesity were treated orally with these compounds or vehicle (Veh) for 28 days. Standard diet-fed mice treated with Veh served as controls. Key Results Enhanced expression of CB1 receptors and iNOS in renal tubules was found in human kidney patients with obesity and other CKDs. The hybrid inhibitor ameliorated obesity-induced kidney morphological and functional changes via decreasing kidney inflammation, fibrosis, oxidative stress, and renal injury. Some of these features were independent of the improved metabolic profile mediated via inhibition of CB1 receptors. An additional interesting finding is that these beneficial effects on the kidney were partially associated with modulating renal adiponectin signalling. Conclusions and Implications Collectively, our results highlight the therapeutic relevance of blocking CB1 receptors and iNOS in ameliorating obesity-induced CKD.
C1 [Udi, Shiran; Hinden, Liad; Ahmad, Majdoleen; Drori, Adi; Tam, Joseph] Hebrew Univ Jerusalem, Fac Med, Sch Pharm, Inst Drug Res,Obes & Metab Lab, POB 12065, IL-91120 Jerusalem, Israel.
   [Iyer, Malliga R.; Cinar, Resat] NIAAA, Lab Physiol Studies, NIH, Bethesda, MD USA.
   [Herman-Edelstein, Michal] Rabin Med Ctr, Dept Nephrol & Hypertens, Petah Tiqwa, Israel.
   [Herman-Edelstein, Michal] Tel Aviv Univ, Sackler Med Sch, Tel Aviv, Israel.
C3 Hebrew University of Jerusalem; National Institutes of Health (NIH) -
   USA; NIH National Institute on Alcohol Abuse & Alcoholism (NIAAA); Rabin
   Medical Center; Tel Aviv University; Sackler Faculty of Medicine
RP Tam, J (corresponding author), Hebrew Univ Jerusalem, Fac Med, Sch Pharm, Inst Drug Res,Obes & Metab Lab, POB 12065, IL-91120 Jerusalem, Israel.
EM yossit@ekmd.huji.ac.il
RI Hinden, Liad/ABG-4180-2021; Cinar, Resat/H-7219-2019; CINAR,
   RESAT/E-5755-2010
OI CINAR, RESAT/0000-0002-8597-7253; Tam, Joseph/0000-0002-0948-0093;
   Hinden, Liad/0000-0002-0307-4350
FU European Research Council [676841]; European Research Council (ERC)
   [676841] Funding Source: European Research Council (ERC)
FX European Research Council, Grant/Award Number: 676841
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NR 63
TC 49
Z9 49
U1 0
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0007-1188
EI 1476-5381
J9 BRIT J PHARMACOL
JI Br. J. Pharmacol.
PD JAN
PY 2020
VL 177
IS 1
BP 110
EP 127
DI 10.1111/bph.14849
EA DEC 2019
PG 18
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA KY5SP
UT WOS:000504578400001
PM 31454063
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Wickrama, KAS
   Lee, TK
   O'Neal, CW
AF Wickrama, Kandauda A. S.
   Lee, Tae-Kyoung
   O'Neal, Catherine Walker
TI Stressful Life Experiences in Adolescence and Cardiometabolic Risk
   Factors in Young Adulthood
SO JOURNAL OF ADOLESCENT HEALTH
LA English
DT Article
DE Biological markers; Cardiovascular health; Life events; Metabolic
   health; Socioeconomic stress
ID ADVERSE CHILDHOOD EXPERIENCES; ALLOSTATIC LOAD; PSYCHOSOCIAL FACTORS;
   HEALTH; DISADVANTAGE; TRAJECTORIES; EXPOSURE; CONTEXT; SCORES; IMPACT
AB Purpose: An increasing number of studies have provided evidence for the persistent influence of childhood/adolescent socioeconomic adversities on subsequent health outcomes. However, less is known about the distinct and additive influences of these early socioeconomic adversities and adolescents' own stressful life experiences on health outcomes in young adulthood.
   Methods: We used data from 11,030 adolescents who participated in the National Longitudinal Study of Adolescent Health at Waves 1, 3, and 4 and provided biomarker data at Wave 4. Three early socioeconomic adversities (community socioeconomic adversity, family economic hardship, and low parental education) were evaluated. Adolescents' stressful transition to young adulthood was captured by six specific precocious life events as follows: early sex, early marriage or cohabitation, early leaving home, early pregnancy, early employment, and truncated education. A summary measure of cardiovascular and metabolic disease risk was assessed using nine biomarkers. Univariate, bivariate, and multivariate regression analyses were employed.
   Results: Early socioeconomic adversities and stressful life transition events were uniquely associated with elevated levels of cardiometabolic (CM) biomarkers and cumulative CM disease risk. For all of the biomarkers, young adults in high-adversity/stress groups were more likely to be in the high CM disease risk groups (>75th percentile) than in the low-adversity/stress groups.
   Conclusions: These findings provide support for the influence of multiple early socioeconomic adversities and adolescents' stressful life transitions on their CM disease risk as young adults. Increased efforts to prevent and mitigate these experiences may improve disease risks across a number of biomarkers. (C) 2015 Society for Adolescent Health and Medicine. All rights reserved.
C1 [Wickrama, Kandauda A. S.; Lee, Tae-Kyoung; O'Neal, Catherine Walker] Univ Georgia, Dept Human Dev & Family Sci, Athens, GA 30602 USA.
C3 University System of Georgia; University of Georgia
RP O'Neal, CW (corresponding author), Univ Georgia, Dept Human Dev & Family Sci, 103 Family Sci Ctr,House A, Athens, GA 30602 USA.
EM cwalker1@uga.edu
RI Lee, Tae/AAE-7907-2021
OI Lee, Tae Kyoung/0000-0001-8712-3182
FU Eunice Kennedy Shriver National Institute of Child Health and Human
   Development [P01-HD31921]
FX This research uses data from Add Health, a program project directed by
   Kathleen Mullan Harris, designed by J. Richard Udry, Peter S. Bearman,
   and Kathleen Mullan Harris at the University of North Carolina at Chapel
   Hill, and funded by grant P01-HD31921 from the Eunice Kennedy Shriver
   National Institute of Child Health and Human Development, with
   cooperative funding from 23 other federal agencies and foundations. No
   direct support was received from grant P01-HD31921 for this analysis.
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NR 38
TC 32
Z9 33
U1 0
U2 25
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1054-139X
EI 1879-1972
J9 J ADOLESCENT HEALTH
JI J. Adolesc. Health
PD APR
PY 2015
VL 56
IS 4
BP 456
EP 463
DI 10.1016/j.jadohealth.2014.12.009
PG 8
WC Psychology, Developmental; Public, Environmental & Occupational Health;
   Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Public, Environmental & Occupational Health; Pediatrics
GA CE3BC
UT WOS:000351698100017
PM 25659202
DA 2025-06-11
ER

PT J
AU Kobayashi, H
   Uchimura, K
   Ishii, T
   Takahashi, K
   Mori, K
   Tsuchiya, K
   Furuya, F
AF Kobayashi, Hidetoshi
   Uchimura, Kohei
   Ishii, Toshihisa
   Takahashi, Kazuya
   Mori, Kentaro
   Tsuchiya, Kyoichiro
   Furuya, Fumihiko
TI Intelectin1 ameliorates macrophage activation via inhibiting the
   nuclear factor kappa B pathway
SO ENDOCRINE JOURNAL
LA English
DT Article
DE ER-stress; Inflammation; Nuclear factor kappa B; Macrophage
ID ENDOPLASMIC-RETICULUM STRESS; GUT MICROBIOTA; OMENTIN; ADIPONECTIN;
   SERUM; INFLAMMATION; MECHANISMS; EXPRESSION; OBESITY; GENE
AB Inteletin1 (Itln1) is an adipokine that is abundantly expressed in intestine, ovary, and lung. The expression levels of ITLN1 are decreased in the presence of diabetes or obesity, but the mechanisms of its production and function are still controversial. The aim of this study is to elucidate the mechanisms of ITLN1 synthesis and ITLN1-associated macrophage activation. To analyze the effects of high fat and high-carbohydrate diet (HFHCD) on the expression of ITLN1 in the intestine, the mice were fed a HFHCD for 8 weeks. HFHCD feeding enhanced the endoplasmic reticulum (ER)-stress in the intestine and inhibited the expression of Itln1 in the intestinal endocrine cells and lowered circulating ITLN1 levels. In contrast, treatment with a chemical chaperone and reduction of ER-stress restored the expression of Itln1 in the intestine of HFHCD-fed mice. Furthermore, in vitro studies indicated that ITLN1 physically interacts with adiponectin receptor 1 and suppresses lipopolysaccharide-induced mRNA expressions of pro-inflammatory cytokines and phagocytosis activities via inhibition of the nuclear factor kappa B-signaling pathway in macrophages. These results suggest that diet-induced ER-stress decreases circulating ITLN1 via inhibition of its synthesis in the intestine, and a reduction of circulating ITLN1 might enhanced the expression of proinflammatory cytokines and macrophage activation, following exacerbate the chronic inflammation of metabolic syndrome.
C1 [Kobayashi, Hidetoshi] Nirasaki Sogo Hosp, Dept Internal Med, Nirasaki, Yamanashi, Japan.
   [Uchimura, Kohei; Ishii, Toshihisa; Takahashi, Kazuya; Furuya, Fumihiko] Univ Yamanashi, Interdisciplinary Grad Sch Med & Engn, Dept Internal Med, Div Nephrol, Kofu, Yamanashi, Japan.
   [Mori, Kentaro] Washington Univ, St Louis Sch Med, Dept Dev Biol, St Louis, MO 63110 USA.
   [Tsuchiya, Kyoichiro] Univ Yamanashi Hosp, Dept Diabet & Endocrinol, Chuo, Yamanashi, Japan.
C3 University of Yamanashi; Washington University (WUSTL); Saint Louis
   University; University of Yamanashi
RP Furuya, F (corresponding author), Univ Yamanashi, Interdisciplinary Grad Sch Med & Engn, Dept Internal Med, Div Nephrol, 1111 Shimokato, Chuo, Yamanashi 4093894, Japan.
EM ffuruya@yamanashi.ac.jp
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NR 35
TC 8
Z9 8
U1 1
U2 8
PU JAPAN ENDOCRINE SOC
PI KYOTO
PA 75  YANAGINOBANBA NISHIIRU-MASUYA-CHO, SANJOU-DORI, NAKAGYOU-KU, KYOTO,
   604-8111, JAPAN
SN 0918-8959
EI 1348-4540
J9 ENDOCR J
JI Endocr. J.
PY 2022
VL 69
IS 5
BP 539
EP 546
DI 10.1507/endocrj.EJ21-0438
EA DEC 2021
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 1W5BF
UT WOS:000736584900001
PM 34866068
OA gold
DA 2025-06-11
ER

PT J
AU Luc, K
   Schramm-Luc, A
   Guzik, TJ
   Mikolajczyk, TP
AF Luc, K.
   Schramm-Luc, A.
   Guzik, T. J.
   Mikolajczyk, T. P.
TI OXIDATIVE STRESS AND INFLAMMATORY MARKERS IN PREDIABETES AND DIABETES
SO JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
LA English
DT Review
DE prediabetes; diabetes; metabolic syndrome; hyperglycemia; reactive
   oxygen species; oxidative stress; adipose tissue; inflammation;
   anti-diabetic drugs
ID GLUCAGON-LIKE PEPTIDE-1; IMPAIRED GLUCOSE-TOLERANCE; NITRIC-OXIDE
   SYNTHASE; DIPEPTIDYL PEPTIDASE-4 INHIBITOR; DYSFUNCTIONAL
   ADIPOSE-TISSUE; PANCREATIC BETA-CELLS; C-REACTIVE PROTEIN;
   INSULIN-RESISTANCE; ENDOTHELIAL DYSFUNCTION; HYPERGLYCEMIC MEMORY
AB Prediabetes is a state of elevated plasma glucose in which the threshold for diabetes has not yet been reached and can predispose to the development of type 2 diabetes and cardiovascular diseases. Insulin resistance and impaired beta-cell function are often already present in prediabetes. Hyperglycemia can upregulate markers of chronic inflammation and contribute to increased reactive oxygen species (ROS) generation, which ultimately cause vascular dysfunction. Conversely, increased oxidative stress and inflammation can lead to insulin resistance and impaired insulin secretion. Proper treatment of hyperglycemia and inhibition of ROS overproduction is crucial for delaying onset of diabetes and for prevention of cardiovascular complications. Thus, it is imperative to determine the mechanisms involved in the progression from prediabetes to diabetes including a clarification of how old and new medications affect oxidative and immune mechanisms of diabetes. In this review, we discuss the relationship between oxidative stress and hyperglycemia along with links between inflammation and prediabetes. Additionally, the effects of hyperglycemic memory, microvesicles, micro-RNA, and epigenetic regulation on inflammation, oxidative state, and glycemic control are highlighted. Adipose tissue and their influence on chronic inflammation are also briefly reviewed. Finally, the role of immune-targeted therapies and anti-diabetic medication on glycemic control and oxidative stress are discussed.
C1 [Luc, K.; Schramm-Luc, A.; Guzik, T. J.; Mikolajczyk, T. P.] Jagiellonian Univ, Fac Med, Dept Internal & Agr Med, Med Coll, 1 Skarbowa St, PL-31121 Krakow, Poland.
   [Guzik, T. J.] Univ Glasgow, Inst Cardiovasc & Med Sci, Glasgow, Lanark, Scotland.
   [Mikolajczyk, T. P.] Univ Glasgow, Inst Infect Immun & Inflammat, Glasgow, Lanark, Scotland.
C3 Jagiellonian University; Collegium Medicum Jagiellonian University;
   University of Glasgow; University of Glasgow
RP Mikolajczyk, TP (corresponding author), Jagiellonian Univ, Fac Med, Dept Internal & Agr Med, Med Coll, 1 Skarbowa St, PL-31121 Krakow, Poland.
EM tomaszp.mikolajczyk@uj.edu.pl
RI Guzik, Tomasz/AAM-5007-2020; Mikolajczyk, Tomasz/AFQ-2278-2022;
   Schramm-Luc, Agata/MFZ-7343-2025
OI Mikolajczyk, Tomasz/0000-0002-7990-2896; Guzik,
   Tomasz/0000-0002-5039-7849
FU Polish National Centre for Research and development
   [ERACVD/PLAQUEFIGHT/5/2018 (K/NCB/000048-TJG), ERACVD/NEMO/7/2019
   (K/NCB/000052-TPM)]
FX This manuscript was supported by the Polish National Centre for Research
   and development ((ERACVD/PLAQUEFIGHT/5/2018 (K/NCB/000048-TJG) and
   ERACVD/NEMO/7/2019 (K/NCB/000052-TPM)).
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NR 197
TC 459
Z9 477
U1 12
U2 94
PU POLISH PHYSIOLOGICAL SOC
PI GRZEGORZECKA
PA JAGIELLONIAN UNIV SCHOOL MED, INST PHYSIOLOGY, 31-531 KRAKOW, 16
   GRZEGORZECKA, POLAND
SN 0867-5910
J9 J PHYSIOL PHARMACOL
JI J. Physiol. Pharmacol.
PD DEC
PY 2019
VL 70
IS 6
BP 809
EP 824
DI 10.26402/jpp.2019.6.01
PG 16
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA LD2FH
UT WOS:000525846300001
PM 32084643
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Rocha, JC
   Martins, MJ
AF Rocha, Julio Cesar
   Martins, Maria Joao
TI Oxidative stress in Phenylketonuria: future directions
SO JOURNAL OF INHERITED METABOLIC DISEASE
LA English
DT Review
ID TOTAL ANTIOXIDANT STATUS; SERUM UBIQUINONE-10 CONCENTRATIONS;
   LOW-DENSITY-LIPOPROTEIN; METABOLIC SYNDROME; COENZYME Q(10);
   FREE-RADICALS; SELENIUM SUPPLEMENTATION; GLUTATHIONE-PEROXIDASE; PLASMA
   PHENYLALANINE; DIETARY CONTROL
AB Phenylketonuria represents the most prevalent inborn error of amino acid metabolism. In early diagnosed patients adequate and continued dietary treatment results in a good neurologic outcome. Natural protein and phenylalanine-restricted diet, even if rich in fruits and vegetables, represents a serious risk for nutritional deficiencies, albeit universally accepted. In the last few years, a growing number of reports have been describing oxidative stress as a concern in phenylketonuric patients. The diet itself includes good sources of dietary antioxidants (phytochemicals, some vitamins and minerals) but also a risk factor for some deficiencies (selenium, zinc, ubiquinone-10 and L-carnitine). Additionally, the extreme stringency of the diet may impose a reduced synthesis of endogenous antioxidants (like ubiquinone-10 and glutathione). Furthermore, increased phenylalanine levels, and its metabolites, may enhance the endogenous synthesis of reactive species and free radicals and/or interfere with the endogenous synthesis of enzymatic antioxidants (like glutathione peroxidase). Therefore, oxidative stress will probably increase, mainly in late diagnosed patients or in those with bad metabolic control. Considering the known association between oxidative stress, obesity and cardiovascular disease, it seems advisable to look further to the impact of oxidative stress on body macromolecules and structures (like lipoprotein oxidation), especially in phenylketonuric patients with late diagnosis or bad metabolic control, in order to prevent future increased risks. Recommendations for PKU patient's clinical follow-up improvement and educational goals are included.
C1 [Rocha, Julio Cesar] INSA, Ctr Genet Med Jacinto de Magalhaes, IP, P-4099028 Oporto, Portugal.
   [Martins, Maria Joao] Univ Porto, Fac Med, Dept Biochem FCT U38, P-4200319 Oporto, Portugal.
C3 Universidade do Porto
RP Rocha, JC (corresponding author), INSA, Ctr Genet Med Jacinto de Magalhaes, IP, Praca Pedro Nunes 88, P-4099028 Oporto, Portugal.
EM julio.rocha@insa.min-saude.pt
RI Martins, Maria João/ABC-8271-2021; Rocha, Julio Cesar/K-5399-2013
OI Martins, Maria Joao/0000-0002-3560-3261; Rocha, Julio
   Cesar/0000-0002-4977-8345
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NR 97
TC 50
Z9 52
U1 0
U2 21
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0141-8955
EI 1573-2665
J9 J INHERIT METAB DIS
JI J. Inherit. Metab. Dis.
PD MAY
PY 2012
VL 35
IS 3
BP 381
EP 398
DI 10.1007/s10545-011-9417-2
PG 18
WC Endocrinology & Metabolism; Genetics & Heredity; Medicine, Research &
   Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Genetics & Heredity; Research & Experimental
   Medicine
GA 921QN
UT WOS:000302492300001
PM 22116469
DA 2025-06-11
ER

PT J
AU Du, KY
   Ding, JX
AF Du, Keyong
   Ding, Jixin
TI Insulin Regulates TRB3 and Other Stress-Responsive Gene Expression
   through Induction of C/EBPβ
SO MOLECULAR ENDOCRINOLOGY
LA English
DT Article
ID BINDING-PROTEIN-BETA; ENDOPLASMIC-RETICULUM; ER STRESS; ADIPOCYTE
   DIFFERENTIATION; GLUCOSE-HOMEOSTASIS; INDUCED APOPTOSIS; PPAR-ALPHA;
   TRANSCRIPTION; RESISTANCE; TRIBBLES
AB Pseudokinase TRB3 is an inducible gene whose expression is regulated by stress response and insulin and associated with insulin resistance and metabolic syndrome. In this report, we have investigated the mechanism under which insulin regulates TRB3 gene expression and demonstrated that insulin induces TRB3 expression via C/EBP beta. We found that in Fao hepatoma and 3T3-L1 adipocytes, C/EBP beta expression induced by insulin preceded that of TRB3 and that mutation of the C/EBP beta binding site in TRB3 promoter abolished the responsiveness of the TRB3 gene to insulin. We further showed that ectopic expression of C/EBP beta augmented, whereas knockdown of C/EBP beta reduced, TRB3 expression induced by insulin. In addition, we presented data to show that insulin, through a similar mechanism under which insulin induces TRB3 expression, promotes the expression of genes such as ANAS, ATF3, BIP, and CHOP, which are typical stress-responsive genes. We also examined the impact of C/EBP beta expression on Akt activation and found that inaction of C/EBP beta not only augmented Akt activation but also obliterated the suppression of Akt activation due to prolonged insulin stimulation. We suggest, through induction of C/EBP beta in hepatic cells and adipocytes, that insulin induces the expression of stress-responsive genes, which may represent a novel insulin action. (Molecular Endocrinology 23: 475-485, 2009)
C1 [Du, Keyong; Ding, Jixin] Tufts Med Ctr, Mol Oncol Res Inst, Boston, MA 02111 USA.
C3 Tufts Medical Center
RP Du, KY (corresponding author), Tufts Med Ctr, Mol Oncol Res Inst, Boston, MA 02111 USA.
EM kdu@tufts-nemc.org
FU The American Diabetes Association
FX We thank Dr. Jacob Friedman ( University of Colorado) for C/EBP beta
   shRNA. Address all correspondence and requests for reprints to: Keyong
   Du, Molecular Oncology Research Institute, Tufts Medical Center, Boston,
   Massachusetts 02111. E-mail: kdu@tufts-nemc.org. K.D. is the recipient
   of Thomas Lee Career Development Award from The American Diabetes
   Association. Disclosure Summary: The authors have nothing to disclose.
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NR 49
TC 32
Z9 40
U1 0
U2 1
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0888-8809
EI 1944-9917
J9 MOL ENDOCRINOL
JI Mol. Endocrinol.
PD APR
PY 2009
VL 23
IS 4
BP 475
EP 485
DI 10.1210/me.2008-0284
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 426KK
UT WOS:000264707000006
PM 19164449
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Chandra, RV
   Srinivas, G
   Reddy, AA
   Reddy, BH
   Reddy, C
   Nagarajan, S
   Naveen, A
AF Chandra, Rampalli Viswa
   Srinivas, Gorremuchu
   Reddy, Aileni Amarender
   Reddy, Bavigadda Harish
   Reddy, Chakravarthy
   Nagarajan, Sripriya
   Naveen, Anumala
TI Locally delivered antioxidant gel as an adjunct to nonsurgical therapy
   improves measures of oxidative stress and periodontal disease
SO JOURNAL OF PERIODONTAL AND IMPLANT SCIENCE
LA English
DT Article
DE Antioxidants; Oxidative stress; Periodontitis
ID GINGIVAL CREVICULAR FLUID; MICROBIAL CHALLENGE; METABOLIC SYNDROME;
   LYCOPENE; INFLAMMATION; RATS
AB Purpose: The present study has two aims; firstly, it attempts to verify the presence of oxidative stress by estimating the reactive oxygen species (ROS) levels in periodontal pockets >= 5 mm as compared to controls. The second aim is to evaluate the effect of lycopene as a locally delivered antioxidant gel on periodontal health and on the gingival crevicular fluid (GCF) levels of 8-hydroxydeoxyguanosine (8-OHdG), a marker of oxidative injury.
   Methods: Thirty-one subjects participated in this study. In the pretreatment phase, the ROS levels in pockets >= 5 mm were measured by flow cytometry. Three sites in each subject were randomly assigned into each of the following experimental groups: sham group, only scaling and root planing (SRP) was done; placebo group, local delivery of placebo gel after SRP; and lycopene group, local delivery of lycopene gel after SRP. Clinical parameters included recording site-specific measures of GCF 8-OHdG, plaque, gingivitis, probing depth, and clinical attachment level.
   Results: The gel, when delivered to the sites with oxidative stress, was effective in increasing clinical attachment and in reducing gingival inflammation, probing depth, and 8-OHdG levels as compared to the placebo and sham sites.
   Conclusions: From this trial conducted over a period of 6 months, it was found that locally delivered lycopene seems to be effective in reducing the measures of oxidative stress and periodontal disease.
C1 [Chandra, Rampalli Viswa; Srinivas, Gorremuchu; Reddy, Aileni Amarender; Reddy, Bavigadda Harish; Reddy, Chakravarthy; Naveen, Anumala] SVS Inst Dent Sci, Dept Periodont, Mahabubnagar, India.
   [Nagarajan, Sripriya] SVS Inst Dent Sci, Dept Prevent & Community Dent, Mahabubnagar, India.
RP Chandra, RV (corresponding author), SVS Inst Dent Sci, Dept Periodont, Mahabubnagar, India.
EM viswachandra@hotmail.com
OI Viswa Chandra, Rampalli/0000-0002-8912-8953
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NR 40
TC 23
Z9 24
U1 0
U2 7
PU KOREAN ACAD PERIODONTOLOGY
PI SEOUL
PA OFFICIAL B-D 2212, 163 SINMUNRO 1-GA, JONGNO-GU, SEOUL, 110-990, SOUTH
   KOREA
SN 2093-2278
EI 2093-2286
J9 J PERIODONTAL IMPLAN
JI J. Periodontal Implant Sci.
PD JUN
PY 2013
VL 43
IS 3
BP 121
EP 129
DI 10.5051/jpis.2013.43.3.121
PG 9
WC Dentistry, Oral Surgery & Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dentistry, Oral Surgery & Medicine
GA AP8QN
UT WOS:000342344000003
PM 23837126
OA Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Xu, JQ
   Zhou, XQ
   Gao, H
   Chen, C
   Deng, QC
   Huang, QD
   Ma, J
   Wan, ZY
   Yang, JE
   Huang, FH
AF Xu, Jiqu
   Zhou, Xiaoqi
   Gao, Hui
   Chen, Chang
   Deng, Qianchun
   Huang, Qingde
   Ma, Jing
   Wan, Zhengyang
   Yang, Jin'e
   Huang, Fenghong
TI Micronutrients-fortified rapeseed oil improves hepatic lipid
   accumulation and oxidative stress in rats fed a high-fat diet
SO LIPIDS IN HEALTH AND DISEASE
LA English
DT Article
DE Rapeseed oil; Polyphenols; Tocopherols; Phytosterols; Lipid
   accumulation; Oxidant stress
ID GREEN TEA; EPIGALLOCATECHIN GALLATE; SUPEROXIDE-DISMUTASE;
   METABOLIC-SYNDROME; BETA-SITOSTEROL; INDUCED OBESITY; LIVER-DISEASE;
   PLANT STEROLS; MICE; PLASMA
AB Intake of high-fat diet is associated with increased fatty livers. Hepatic lipid accumulation and oxidative stress are key pathophysiological mechanisms in this disease. Micronutrients polyphenols, tocopherols and phytosterols in rapeseed exert potential benefit to hepatoprotection, but most of these micronutrients are removed by the traditional refining process. The purpose of the present study was to determine whether rapeseed oil fortified with these micronutrients can decrease hepatic lipid accumulation and oxidative stress induced by high-fat diet. Sprague-Dawley rats received rodent diet contained 20% fat whose source was refined rapeseed oil (RRO) or fortified RRO with low, middle and high quantities of these micronutrients for 10 weeks. Intake of RRO caused a remarkable hepatic steatosis. Micronutrients supplementation was effective in reducing steatosis as well as total triglyceride and total cholesterol contents in liver. These micronutrients also significantly increased hepatic antioxidant defense capacities, as evaluated by the significant elevation in the activities of SOD and GPx as well as the level of GSH, and the significant decline in lipid peroxidation. These findings suggest that rapeseed oil fortified with micronutrients polyphenols, tocopherols and phytosterols may contribute to prevent fatty livers such as nonalcoholic fatty liver disease by ameliorating hepatic lipid accumulation and oxidative stress.
C1 [Xu, Jiqu; Deng, Qianchun; Huang, Qingde; Yang, Jin'e; Huang, Fenghong] Chinese Acad Agr Sci, Dept Prod Proc & Nutriol, Oil Crops Res Inst, Wuhan 430062, Peoples R China.
   [Xu, Jiqu; Deng, Qianchun; Huang, Qingde; Yang, Jin'e; Huang, Fenghong] Hubei Key Lab Lipid Chem & Nutr, Wuhan 430062, Peoples R China.
   [Zhou, Xiaoqi; Gao, Hui] Huazhong Univ Sci & Technol, Sch Publ Hlth, Dept Nutr & Food Hyg, Tongji Med Coll, Wuhan 430030, Peoples R China.
   [Chen, Chang] 1 Hosp Yichang, Dept Gastroenterol, Yichang 443000, Peoples R China.
   [Ma, Jing; Wan, Zhengyang] Yichang Ctr Dis Control & Prevent, Yichang 443000, Peoples R China.
C3 Chinese Academy of Agricultural Sciences; Oil Crops Research Institute,
   CAAS; Huazhong University of Science & Technology
RP Huang, FH (corresponding author), Chinese Acad Agr Sci, Dept Prod Proc & Nutriol, Oil Crops Res Inst, 2 Xudong 2nd Rd, Wuhan 430062, Peoples R China.
EM fhhuang@foxmail.com
FU National Science Foundation of China [NSFC-31271856]; Open Foundation of
   Hubei Key Laboratory of Lipid Chemistry and Nutrition [2012007];
   earmarked fund for Modern Agro-industry Technology Research System
   [CARS-13]
FX This work was supported by National Science Foundation of China
   (NSFC-31271856), Open Foundation of Hubei Key Laboratory of Lipid
   Chemistry and Nutrition (2012007), and the earmarked fund for Modern
   Agro-industry Technology Research System (CARS-13).
CR Attorri L, 2010, ATHEROSCLEROSIS, V213, P422, DOI 10.1016/j.atherosclerosis.2010.07.003
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NR 37
TC 8
Z9 8
U1 0
U2 35
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1476-511X
J9 LIPIDS HEALTH DIS
JI Lipids Health Dis.
PD MAR 6
PY 2013
VL 12
AR 28
DI 10.1186/1476-511X-12-28
PG 6
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA 109SN
UT WOS:000316389000001
PM 23510587
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Boldaji, RB
   Akhlaghi, M
   Sagheb, MM
   Esmaeilinezhad, Z
AF Boldaji, Reza Barati
   Akhlaghi, Masoumeh
   Sagheb, Mohammad Mahdi
   Esmaeilinezhad, Zahra
TI Pomegranate juice improves cardiometabolic risk factors, biomarkers of
   oxidative stress and inflammation in hemodialysis patients: a randomized
   crossover trial
SO JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
LA English
DT Article
DE hemodialysis; hypertension; inflammation; lipid profile; oxidative
   stress; pomegranate
ID BLOOD-PRESSURE; EXTRACT SUPPLEMENTATION; LIPID-PEROXIDATION;
   NUTRITIONAL-STATUS; NITRIC-OXIDE; DISORDERS; DECREASES; DISEASE; PLASMA;
   CONSUMPTION
AB BACKGROUND Pomegranate has antioxidant, cardioprotective and anti-inflammatory properties. We designed a crossover study aimed at determining if consumption of pomegranate juice (PJ) improves lipid profile and oxidative and inflammatory biomarkers of hemodialysis patients. Forty-one hemodialysis patients were randomly assigned to one of two groups: PJ-treated group receiving 100 mL of natural PJ immediately after their dialysis session three times a week and the control group receiving the usual care. After 8 weeks, a 4-week washout period was established and then the role of the groups was exchanged. Lipid profile, blood pressure and oxidative and inflammatory biomarkers were measured before and after each sequence. RESULTS Based on the results of intention-to-treat analysis, triglycerides were decreased in PJ condition and increased in the controls. Conversely, high-density lipoprotein cholesterol was increased in PJ and decreased in the control group. Total and low-density lipoprotein cholesterol did not significantly change in either condition. Systolic and diastolic blood pressure significantly decreased in PJ condition. Total antioxidant capacity increased in PJ condition (P < 0.001) and decreased in the controls (P < 0.001). Conversely, malondialdehyde and interleukin-6 decreased in PJ (P < 0.001) and increased in the control group (P <= 0.001). The changes of these biomarkers were significantly different between the two conditions. CONCLUSIONS Eight-week PJ consumption showed beneficial effects on blood pressure, serum triglycerides, high-density lipoprotein cholesterol, oxidative stress and inflammation in hemodialysis patients. (c) 2019 Society of Chemical Industry
C1 [Boldaji, Reza Barati; Akhlaghi, Masoumeh; Esmaeilinezhad, Zahra] Shiraz Univ Med Sci, Nutr Res Ctr, Sch Nutr & Food Sci, Shiraz, Iran.
   [Sagheb, Mohammad Mahdi] Shiraz Univ Med Sci, Sch Med, Dept Nephrol, Shiraz, Iran.
C3 Shiraz University of Medical Science; Shiraz University of Medical
   Science
RP Akhlaghi, M (corresponding author), Shiraz Univ Med Sci, Nutr Res Ctr, Sch Nutr & Food Sci, Shiraz, Iran.
EM msm.akhlaghi@gmail.com
RI sadeghi, mohammad/AAR-9996-2020; Akhlaghi, Masoumeh/R-4685-2017
OI Akhlaghi, Masoumeh/0000-0003-3868-0227; Barati-Boldaji,
   Reza/0000-0002-7251-9202
FU Shiraz University of Medical Sciences [94-01-84-10361]
FX The results presented herein were extracted from a thesis written by
   RBB. The project was approved by Shiraz University of Medical Sciences
   with project no. 94-01-84-10361.
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NR 55
TC 57
Z9 59
U1 0
U2 11
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-5142
EI 1097-0010
J9 J SCI FOOD AGR
JI J. Sci. Food Agric.
PD JAN 30
PY 2020
VL 100
IS 2
BP 846
EP 854
DI 10.1002/jsfa.10096
EA NOV 2019
PG 9
WC Agriculture, Multidisciplinary; Chemistry, Applied; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture; Chemistry; Food Science & Technology
GA OA4DC
UT WOS:000497487600001
PM 31646650
DA 2025-06-11
ER

PT J
AU Li, TH
   Feng, R
   Zhao, CY
   Wang, Y
   Wang, J
   Liu, SS
   Cao, JW
   Wang, HY
   Wang, T
   Guo, YT
   Lu, ZB
AF Li, Tianhe
   Feng, Run
   Zhao, Chenyang
   Wang, Yue
   Wang, Jian
   Liu, Shasha
   Cao, Jianwei
   Wang, Hongyun
   Wang, Ting
   Guo, Yuting
   Lu, Zhongbing
TI Dimethylarginine Dimethylaminohydrolase 1 Protects Against High-Fat
   Diet-Induced Hepatic Steatosis and Insulin Resistance in Mice
SO ANTIOXIDANTS & REDOX SIGNALING
LA English
DT Article
DE ADMA; DDAH1; AMPK; hepatic steatosis
ID ACETYL-COA CARBOXYLASE; NF-KAPPA-B; ASYMMETRIC DIMETHYLARGININE;
   LIVER-DISEASE; NITRIC-OXIDE; ENDOTHELIAL DYSFUNCTION; OXIDATIVE STRESS;
   METABOLIC SYNDROME; CARDIOVASCULAR-DISEASE; PLASMA-CONCENTRATIONS
AB Aims: High plasma concentrations of asymmetric dimethylarginine (ADMA), an endogenous nitric oxide synthase inhibitor, are associated with hepatic dysfunction in patients with nonalcoholic fatty liver disease (NAFLD). However, it is unknown whether ADMA is involved in the pathogenesis of NAFLD. Dimethylarginine dimethylaminohydrolase 1 (DDAH1) is an enzyme that degrades ADMA. In this study, we used Ddah1(-/-) mice to investigate the effects of the ADMA/DDAH1 pathway on high-fat diet (HFD)-induced hepatic steatosis.
   Results: After HFD feeding for 20 weeks, Ddah1(-/-) mice were more obese and had developed more severe hepatic steatosis and worse insulin resistance compared with wild-type (WT) mice. In the livers of HFD-fed mice, loss of DDAH1 resulted in higher levels of lipogenic genes, lower expression of beta-oxidation genes, and greater induction of oxidative stress, endoplasmic reticulum stress, and inflammation than in the WT livers. Furthermore, ADMA treatment in HepG2 cells led to oxidative stress and steatosis, whereas overexpression of DDAH1 attenuated palmitic acid-induced steatosis, oxidative stress, and inflammation.
   Innovation and Conclusion: Our results provide the first direct evidence that the ADMA/DDAH1 pathway has a marked effect on hepatic lipogenesis and steatosis induced by HFD feeding. Our findings suggest that strategies to increase DDAH1 activity in hepatocytes may provide a novel approach to attenuate NAFLD development. Antioxid.
C1 [Li, Tianhe; Feng, Run; Zhao, Chenyang; Wang, Yue; Wang, Jian; Liu, Shasha; Cao, Jianwei; Wang, Hongyun; Wang, Ting; Guo, Yuting; Lu, Zhongbing] Univ Chinese Acad Sci, Coll Life Sci, 19A Yuquanlu, Beijing 100049, Peoples R China.
C3 Chinese Academy of Sciences; University of Chinese Academy of Sciences,
   CAS
RP Lu, ZB (corresponding author), Univ Chinese Acad Sci, Coll Life Sci, 19A Yuquanlu, Beijing 100049, Peoples R China.
EM luzhongbing@ucas.ac.cn
RI Li, TIANHE/MVU-2493-2025; Wang, Jun/A-7261-2013; Li,
   Chenyang/AAH-6030-2021; Guo, Yuting/MHQ-5359-2025
OI LI, TIANHE/0009-0002-6622-2637
FU National Natural Science Foundation of China [81270319, 81470520];
   Chinese Academy of Sciences [KJRH2015-005]
FX This study was supported by grants from the National Natural Science
   Foundation of China (81270319 and 81470520) and Chinese Academy of
   Sciences (KJRH2015-005, Hundred Talents Program and CAS/SAFEA
   International Partnership Program for Creative Research Teams).
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NR 57
TC 31
Z9 31
U1 5
U2 27
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1523-0864
EI 1557-7716
J9 ANTIOXID REDOX SIGN
JI Antioxid. Redox Signal.
PD APR
PY 2017
VL 26
IS 11
BP 599
EP 611
DI 10.1089/ars.2016.6742
PG 13
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA ER0HE
UT WOS:000398467900003
PM 27565538
DA 2025-06-11
ER

PT J
AU Wang, M
   Xu, WX
   Yu, J
   Liu, YY
   Ma, HT
   Ji, CL
   Zhang, CH
   Xue, JA
   Li, RZ
   Cui, HL
AF Wang, Meng
   Xu, Wenxin
   Yu, Jie
   Liu, Yingying
   Ma, Haotian
   Ji, Chunli
   Zhang, Chunhui
   Xue, Jinai
   Li, Runzhi
   Cui, Hongli
TI Astaxanthin From Haematococcus pluvialis Prevents High-Fat
   Diet-Induced Hepatic Steatosis and Oxidative Stress in Mice by Gut-Liver
   Axis Modulating Properties
SO FRONTIERS IN NUTRITION
LA English
DT Article
DE astaxanthin; oxidative stress; hepatic steatosis; lipid metabolism; gut
   microbiota
ID INSULIN-RESISTANCE; METABOLIC SYNDROME; BLOOD-PRESSURE; RNA-SEQ;
   MICROBIOTA; DISEASE; INFLAMMATION; ACTIVATION; PROBIOTICS; APOPTOSIS
AB ScopeEvidence is mounting that astaxanthin (ATX), a xanthophyll carotenoid, used as a nutritional supplement to prevent chronic metabolic diseases. The present study aims to identify the potential function of ATX supplementation in preventing steatohepatitis and hepatic oxidative stress in diet-induced obese mice. Methods and ResultsIn this study, ATX as dose of 0.25, 0.5, and 0.75% have orally administered to mice along with a high-fat diet (HFD) to investigate the role of ATX in regulating liver lipid metabolism and gut microbiota. The study showed that ATX dose-dependently reduces body weight, lipid droplet formation, hepatic triglycerides and ameliorated hepatic steatosis and oxidative stress. 0.75% ATX altered the levels of 34 lipid metabolites related to hepatic cholesterol and fatty acid metabolism which might be associated with downregulation of lipogenesis-related genes and upregulation of bile acid biosynthesis-related genes. The result also revealed that ATX alleviates HFD-induced gut microbiota dysbiosis by significantly inhibiting the growth of obesity-related Parabacteroides and Desulfovibrio while promoting the growth of Allobaculum and Akkermansia. ConclusionThe study results suggested that dietary ATX may prevent the development of hepatic steatosis and oxidative stress with the risk of metabolic disease by gut-liver axis modulating properties.
C1 [Wang, Meng; Xu, Wenxin; Yu, Jie; Liu, Yingying; Ji, Chunli; Zhang, Chunhui; Xue, Jinai; Li, Runzhi; Cui, Hongli] Shanxi Agr Univ, Inst Mol Agr & Bioenergy, Coll Agr, Jinzhong, Peoples R China.
   [Ma, Haotian] Xi An Jiao Tong Univ, Coll Forens Sci, Hlth Sci Ctr, Xian, Peoples R China.
   [Li, Runzhi; Cui, Hongli] Shanxi Agr Univ, State Key Lab Integrat Sustainable Dryland Agr, Taiyuan, Peoples R China.
C3 Shanxi Agricultural University; Xi'an Jiaotong University; Shanxi
   Agricultural University
RP Cui, HL (corresponding author), Shanxi Agr Univ, Inst Mol Agr & Bioenergy, Coll Agr, Jinzhong, Peoples R China.; Cui, HL (corresponding author), Shanxi Agr Univ, State Key Lab Integrat Sustainable Dryland Agr, Taiyuan, Peoples R China.
EM cuihongli@sxau.edu.cn
RI Ji, Chunli/AAH-3420-2019; Zhang, Chun-Hui/AAB-1029-2020; Cui,
   Hongli/GWC-5461-2022
OI Cui, Hongli/0000-0002-2908-2711
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NR 59
TC 16
Z9 17
U1 6
U2 51
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD APR 12
PY 2022
VL 9
AR 840648
DI 10.3389/fnut.2022.840648
PG 17
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 0Z1YN
UT WOS:000790875000001
PM 35495929
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Lanza, GA
   Sestito, A
   Iacovella, S
   Morlacchi, L
   Romagnoli, E
   Schiavoni, G
   Crea, F
   Maseri, A
   Andreotti, F
AF Lanza, GA
   Sestito, A
   Iacovella, S
   Morlacchi, L
   Romagnoli, E
   Schiavoni, G
   Crea, F
   Maseri, A
   Andreotti, F
TI Relation between platelet response to exercise and coronary angiographic
   findings in patients with effort angina
SO CIRCULATION
LA English
DT Article
DE platelets; coronary disease; syndrome X; tests
ID CARDIAC SYNDROME-X; ACUTE MYOCARDIAL-INFARCTION; LEFT-VENTRICULAR
   FUNCTION; ST SEGMENT DEPRESSION; ARTERY DISEASE; MICROVASCULAR ANGINA;
   PHYSICAL EXERTION; PECTORIS; ISCHEMIA; AGGREGATION
AB Background-Platelet reactivity is increased by exercise in patients with obstructive coronary artery disease (CAD) but not in patients with syndrome X. In this study, we prospectively investigated whether the platelet response to exercise might help distinguish, among patients with angina, those with obstructive CAD from those with normal coronary arteries (NCAs).
   Methods and Results-Venous blood samples were collected before and 5 minutes after exercise from 194 consecutive patients with stable angina. Platelet reactivity was measured by the platelet function analyzer (PFA)-100 system as the time for flowing whole blood to occlude a collagen-adenosine diphosphate ring (closure time). Coronary angiography showed CAD in 163 patients (84%) and NCA in 31 patients (16%). Baseline closure time was shorter in NCA patients (78.0+/-16 versus 95.5+/-23 seconds, P<0.0001). With exercise, closure time decreased in CAD patients (-15.5 seconds; 95% confidence limits [CL], -13.0 to -18.0 seconds; P<0.0001), but increased in NCA patients (12.5 seconds; 95% CL, 7.4 to 17.7 seconds; P=0.0004). An increase in closure time with exercise greater than or equal to10 seconds had 100% specificity and positive predictive value for NCAs. Similarly, a decrease greater than or equal to10 seconds had 100% specificity and positive predictive value for CAD. A closure time change (increase or decrease) greater than or equal to10 seconds allowed a correct classification of 55% of all patients.
   Conclusions-Among patients with stable angina, the response of platelet reactivity to exercise was predictive of normal or stenosed coronary arteries at angiography. Specifically, an increase in closure time with exercise greater than or equal to10 seconds was invariably associated with the presence of NCA.
C1 Univ Cattolica Sacro Cuore, Ist Cardiol, I-00168 Rome, Italy.
C3 Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli
RP Univ Cattolica Sacro Cuore, Ist Cardiol, Lgo A Gemelli 8, I-00168 Rome, Italy.
EM g.a.lanza@inwind.it
RI Andreotti, Felicita/A-9962-2019; Lanza, Gaetano/AAC-2660-2019;
   Romagnoli, Enrico/M-7725-2017
OI Andreotti, Felicita/0000-0002-1456-6430; Romagnoli,
   Enrico/0000-0003-1611-7708
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NR 46
TC 44
Z9 48
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0009-7322
EI 1524-4539
J9 CIRCULATION
JI Circulation
PD MAR 18
PY 2003
VL 107
IS 10
BP 1378
EP 1382
DI 10.1161/01.CIR.0000055317.72067.23
PG 5
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 656MW
UT WOS:000181612400010
PM 12642357
OA Bronze
DA 2025-06-11
ER

PT J
AU Feng, RN
   Niu, YC
   Sun, XW
   Li, Q
   Zhao, C
   Wang, C
   Guo, FC
   Sun, CH
   Li, Y
AF Feng, R. N.
   Niu, Y. C.
   Sun, X. W.
   Li, Q.
   Zhao, C.
   Wang, C.
   Guo, F. C.
   Sun, C. H.
   Li, Y.
TI Histidine supplementation improves insulin resistance through suppressed
   inflammation in obese women with the metabolic syndrome: a randomised
   controlled trial
SO DIABETOLOGIA
LA English
DT Article
DE Histidine; Inflammation; Obesity; Oxidative stress
ID LOW-DENSITY-LIPOPROTEIN; ORAL L-HISTIDINE; OXIDATIVE STRESS;
   CARDIOVASCULAR-DISEASE; DOUBLE-BLIND; CARNOSINE; ADIPONECTIN; CYSTEINE;
   ADULTS
AB Aims/hypothesis Increased inflammation and oxidative stress are associated with insulin resistance (IR) and metabolic disorders. Serum histidine levels are lower and are negatively associated with inflammation and oxidative stress in obese women. The objective of this study was to evaluate the efficacy of histidine supplementation on IR, inflammation, oxidative stress and metabolic disorders in obese women with the metabolic syndrome (MetS).
   Methods A total of 100 obese women aged 33-51 years with BMI >= 28 kg/m(2) and diagnosed with MetS were included following a health examination in the community hospital in this randomised, double-blinded, placebo-controlled trial. Participants were allocated to interventions by an investigator using sequentially numbered sealed envelopes and received 4 g/day histidine (n=50) or identical placebo (n=50) for 12 weeks. Participants then attended the same clinic every 2 weeks for scheduled interviews and to count tablets returned. Serum histidine, HOMA-IR, BMI, waist circumference, fat mass, serum NEFA, and variables connected to inflammation and oxidative stress were measured at baseline and 12 weeks. Participants, examining physicians and investigators assessing the outcomes were blinded to group assignment. In addition, the inflammatory mechanisms of histidine were also explored in adipocytes.
   Results At 12 weeks, a total of 92 participants completed this trail. Compared with the placebo group (n=47), histidine supplementation significantly decreased HOMA-IR (-1.09 [95% CI -1.49, -0.68]), BMI (-0.86 kg/m(2) [95% CI -1.55, -0.17]), waist circumference (-2.86 cm [95% CI -3.86, -1.86]), fat mass (-2.71 kg [95% CI -3.69, -1.73]), serum NEFA (-173.26 mu mol/l [95% CI -208.57, -137.94]), serum inflammatory cytokines (TNF-alpha, -3.96 pg/ml [95% CI -5.29, -2.62]; IL-6, -2.15 pg/ml [95% CI -2.52, -1.78]), oxidative stress (superoxide dismutase, 17.84 U/ml [95% CI 15.03, 20.65]; glutathione peroxidase, 13.71 nmol/ml [95% CI 9.65, 17.78]) and increased serum histidine and adiponectin by 18.23 mu mol/l [95% CI 11.74, 24.71] and 2.02 ng/ml [95% CI 0.60, 3.44] in histidine supplementation group (n=45), respectively. There were significant correlations between changes in serum histidine and changes of IR and its risk factors. No side effects were observed during the intervention. In vitro study indicated that histidine suppresses IL6 and TNF mRNA expression and nuclear factor kappa-B (NF-kappa B) protein production in palmitic acid-induced adipocytes in a dose-dependent manner, and these changes were diminished by an inhibitor of NF-kappa B.
   Conclusions/interpretation Histidine supplementation could improve IR, reduce BMI, fat mass and NEFA and suppress inflammation and oxidative stress in obese women with MetS; histidine could improve IR through suppressed pro-inflammatory cytokine expression, possibly by the NF-kappa B pathway, in adipocytes.
C1 [Feng, R. N.; Niu, Y. C.; Sun, X. W.; Zhao, C.; Guo, F. C.; Sun, C. H.; Li, Y.] Harbin Med Univ, Dept Nutr & Food Hyg, Sch Publ Hlth, Harbin, Heilongjiang, Peoples R China.
   [Li, Q.] Harbin Med Univ, Dept Endocrinol, Affiliated Hosp 2, Harbin, Heilongjiang, Peoples R China.
   [Wang, C.] Harbin Med Univ, Ctr Endem Dis Control, Chinese Ctr Dis Control & Prevent, Harbin, Heilongjiang, Peoples R China.
C3 Harbin Medical University; Harbin Medical University; Harbin Medical
   University; Chinese Center for Disease Control & Prevention
RP Sun, CH (corresponding author), Harbin Med Univ, Dept Nutr & Food Hyg, Sch Publ Hlth, 157 Baojian Rd, Harbin, Heilongjiang, Peoples R China.
EM changhao2002sun@gmail.com; liying_helen@yahoo.com
RI Sun, Xiao/U-3439-2017
OI Wang, Cheng/0000-0002-2217-3784
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NR 36
TC 155
Z9 171
U1 1
U2 49
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0012-186X
EI 1432-0428
J9 DIABETOLOGIA
JI Diabetologia
PD MAY
PY 2013
VL 56
IS 5
BP 985
EP 994
DI 10.1007/s00125-013-2839-7
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 142HD
UT WOS:000318787100005
PM 23361591
DA 2025-06-11
ER

PT J
AU Rives, C
   Fougerat, A
   Ellero-Simatos, S
   Loiseau, N
   Guillou, H
   Gamet-Payrastre, L
   Wahli, W
AF Rives, Clemence
   Fougerat, Anne
   Ellero-Simatos, Sandrine
   Loiseau, Nicolas
   Guillou, Herve
   Gamet-Payrastre, Laurence
   Wahli, Walter
TI Oxidative Stress in NAFLD: Role of Nutrients and Food Contaminants
SO BIOMOLECULES
LA English
DT Review
DE steatosis; non-alcoholic fatty liver disease (NAFLD); non-alcoholic
   steatohepatitis (NASH); food contaminant; macronutrients;
   micronutrients; oxidative stress; mitochondria; reactive oxygen species
   (ROS)
ID FATTY LIVER-DISEASE; ENDOCRINE-DISRUPTING CHEMICALS; GUT MICROBIOTA
   DYSBIOSIS; AMELIORATES NONALCOHOLIC STEATOHEPATITIS; INSECTICIDE
   LAMBDA-CYHALOTHRIN; PERSISTENT ORGANIC POLLUTANTS; ENDOPLASMIC-RETICULUM
   STRESS; IMPROVES HEPATIC STEATOSIS; INDUCED LIPID-PEROXIDATION; OXYGEN
   SPECIES PRODUCTION
AB Non-alcoholic fatty liver disease (NAFLD) is often the hepatic expression of metabolic syndrome and its comorbidities that comprise, among others, obesity and insulin-resistance. NAFLD involves a large spectrum of clinical conditions. These range from steatosis, a benign liver disorder characterized by the accumulation of fat in hepatocytes, to non-alcoholic steatohepatitis (NASH), which is characterized by inflammation, hepatocyte damage, and liver fibrosis. NASH can further progress to cirrhosis and hepatocellular carcinoma. The etiology of NAFLD involves both genetic and environmental factors, including an unhealthy lifestyle. Of note, unhealthy eating is clearly associated with NAFLD development and progression to NASH. Both macronutrients (sugars, lipids, proteins) and micronutrients (vitamins, phytoingredients, antioxidants) affect NAFLD pathogenesis. Furthermore, some evidence indicates disruption of metabolic homeostasis by food contaminants, some of which are risk factor candidates in NAFLD. At the molecular level, several models have been proposed for the pathogenesis of NAFLD. Most importantly, oxidative stress and mitochondrial damage have been reported to be causative in NAFLD initiation and progression. The aim of this review is to provide an overview of the contribution of nutrients and food contaminants, especially pesticides, to oxidative stress and how they may influence NAFLD pathogenesis.
C1 [Rives, Clemence; Fougerat, Anne; Ellero-Simatos, Sandrine; Loiseau, Nicolas; Guillou, Herve; Gamet-Payrastre, Laurence; Wahli, Walter] Univ Toulouse, Toxalim Res Ctr Food Toxicol, INP Purpan, INRA,EVT,UPS, F-31300 Toulouse, France.
   [Wahli, Walter] Nanyang Technol Univ Singapore, Lee Kong Chian Sch Med, Clin Sci Bldg,11 Mandalay Rd, Singapore 308232, Singapore.
   [Wahli, Walter] Univ Lausanne, Ctr Integrat Genom, CH-1015 Lausanne, Switzerland.
C3 INRAE; Universite de Toulouse; Universite Toulouse III - Paul Sabatier;
   Nanyang Technological University; University of Lausanne
RP Gamet-Payrastre, L; Wahli, W (corresponding author), Univ Toulouse, Toxalim Res Ctr Food Toxicol, INP Purpan, INRA,EVT,UPS, F-31300 Toulouse, France.; Wahli, W (corresponding author), Nanyang Technol Univ Singapore, Lee Kong Chian Sch Med, Clin Sci Bldg,11 Mandalay Rd, Singapore 308232, Singapore.; Wahli, W (corresponding author), Univ Lausanne, Ctr Integrat Genom, CH-1015 Lausanne, Switzerland.
EM clemence.rives@inrae.fr; anne.fougerat@inrae.fr;
   sandrine.ellero-simatos@inrae.fr; nicolas.loiseau@inrae.fr;
   herve.guillou@inrae.fr; laurence.payrastre@inrae.fr;
   walter.wahli@ntu.edu.sg
RI Guillou, Herve/AAG-2826-2020; LOISEAU, Nicolas/ADN-2394-2022; Wahli,
   Walter/B-1398-2009
OI Guillou, Herve/0000-0002-5363-9081; LOISEAU,
   Nicolas/0000-0003-3783-0879; Ellero-Simatos,
   Sandrine/0000-0002-9282-1804; Wahli, Walter/0000-0002-5966-9089
FU AgreenSkills; Lee Kong Chian School of Medicine, Nanyang Technological
   University Singapore; Region Occitanie; ANR Syneract
FX A.F. is supported by the AgreenSkills and fellowship program. W.W. was
   supported by the Start-Up Grant from the Lee Kong Chian School of
   Medicine, Nanyang Technological University Singapore. This work was also
   funded by ANR Syneract and by grants from Region Occitanie (L.G.P.,
   N.L., H.G., W.W.).
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NR 421
TC 102
Z9 109
U1 7
U2 66
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2218-273X
J9 BIOMOLECULES
JI Biomolecules
PD DEC
PY 2020
VL 10
IS 12
AR 1702
DI 10.3390/biom10121702
PG 64
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA PJ5FR
UT WOS:000601793900001
PM 33371482
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Sibouakaz, D
   Othmani-Mecif, K
   Fernane, A
   Taghlit, A
   Benazzoug, Y
AF Sibouakaz, Dina
   Othmani-Mecif, Khira
   Fernane, Amirouche
   Taghlit, Abdennour
   Benazzoug, Yasmina
TI Biochemical and Ultrastructural Cardiac Changes Induced by High-Fat Diet
   in Female and Male Prepubertal Rabbits
SO ANALYTICAL CELLULAR PATHOLOGY
LA English
DT Article
ID CORONARY-HEART-DISEASE; OXIDATIVE STRESS; METABOLIC SYNDROME; URIC-ACID;
   CARDIOVASCULAR-DISEASE; INSULIN-RESISTANCE; MITOCHONDRIAL MORPHOLOGY;
   DENSITY-LIPOPROTEIN; LIPID-PEROXIDATION; ISCHEMIC STRESS
AB Early weight gain induced by high-fat diet has been identified as a predictor for cardiac disease, one of the most serious public health problems. Our goal is to study the influence of a HFD on biochemical, oxidant stress parameters, and the cardiac ultrastructure in both male and female prepubertal models. Experiments were carried on 24 prepubertal New Zealand white rabbits, randomly assigned to male and female control (MC and FC, resp.) or HFD (MHFD and FHFD, resp.) groups (n = 6) for 3 months. Body and heart weights and some biochemical and oxidative stress parameters such as lipids, calcium, CKMB, MDA, uric acid, ascorbic acid, and AOA are evaluated in plasma and the left ventricle. Under HFD effect, plasma parameters, such as lipids (TL, PL, and LDL-C), MDA, and CK-MB, increase more significantly in male than in female groups, when AA decreases. Some cardiac parameters such as TG and UA increase, when AA and AOA decrease; these variations are more significant in FHFD. In both male and female rabbits, HFD caused changes in heart ultrastructure, junctional complexes, mitochondria size and form, and so on. Early HFD feeding induced overweight, oxidative stress, and metabolic alterations in plasma and the heart of prepubertal rabbits, whereas lipotoxicity has especially a negative impact on male plasma but affects more the female heart ultrastructure.
C1 [Sibouakaz, Dina; Othmani-Mecif, Khira; Fernane, Amirouche; Taghlit, Abdennour; Benazzoug, Yasmina] Univ Sci & Technol Houari Boumediene, Fac Biol Sci, Team ECM Remodeling Biochem, Lab Cellular & Mol Biol, BP 32, Algiers 16111, Algeria.
C3 University Science & Technology Houari Boumediene
RP Othmani-Mecif, K (corresponding author), Univ Sci & Technol Houari Boumediene, Fac Biol Sci, Team ECM Remodeling Biochem, Lab Cellular & Mol Biol, BP 32, Algiers 16111, Algeria.
EM kothmani@ymail.com
RI Benazzoug, Yasmina/AAE-4305-2019; TAGHLIT, Abdennour/AAD-5778-2019;
   FERNANE, Amirouche/AAA-2493-2019
OI TAGHLIT, Abdennour/0000-0002-4023-6259; FERNANE,
   Amirouche/0000-0003-4465-3903; Othmani Mecif, khira/0000-0002-5910-7094
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NR 104
TC 13
Z9 13
U1 0
U2 0
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2210-7177
EI 2210-7185
J9 ANAL CELL PATHOL
JI Anal. Cell. Pathol.
PY 2018
VL 2018
AR 6430696
DI 10.1155/2018/6430696
PG 16
WC Oncology; Cell Biology; Pathology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Cell Biology; Pathology
GA GD1XK
UT WOS:000430294400001
PM 29850391
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Narotzki, B
   Reznick, AZ
   Mitki, T
   Aizenbud, D
   Levy, Y
AF Narotzki, Baruch
   Reznick, Abraham Z.
   Mitki, Tali
   Aizenbud, Dror
   Levy, Yishai
TI Enhanced Cardiovascular Risk and Altered Oxidative Status in Elders with
   Moderate Excessive Body Fat
SO REJUVENATION RESEARCH
LA English
DT Article
ID GREEN TEA; ANTIOXIDANT PROFILE; LIPID-PEROXIDATION; PHYSICAL-ACTIVITY;
   PROTEIN CARBONYL; STRESS; OBESITY; EXERCISE; DAMAGE; DISEASE
AB Aging and obesity are linked to oxidative stress. Oxidative stress may mediate age-related cardiovascular diseases. Although the body mass index (kg/m(2)) defines obesity (>= 30) and overweight (25-29.9), it may fail to detect crucial differences in body fat content in elders. Consequently, we measured body fatness in 42 healthy elders and evaluated their cardiovascular risk factors and the extent of their physical activity. We assessed plasma, erythrocytes, and saliva oxidative stress biomarkers in this population. A higher fat mass was associated with a less active lifestyle, more metabolic syndrome components, an enhanced Framingham 10-year risk score, and augmented insulin resistance. Individuals with excessive body fat had significantly less oral peroxidase enzymes activity than those with normal body fat. Erythrocyte susceptibility to oxidative hemolysis, previously reported to be elevated with physical activity, was marginally lower in the higher fat group. Other biomarkers of oxidative stress in saliva, plasma, and erythrocytes were similar in both groups. A 6% elevation in body fat with a less active lifestyle and an increased cardiovascular risk is associated with a decline in salivary anti-oxidative activity. Such reduced activity may contribute to deteriorating oral health in obese elders. Thus, this study provides novel information on the contribution of excessive body fat to oxidative status and cardiovascular risk in old age.
C1 [Narotzki, Baruch; Reznick, Abraham Z.; Aizenbud, Dror; Levy, Yishai] Technion Israel Inst Technol, Rappaport Fac Med, Haifa, Israel.
   [Mitki, Tali] Clalit Hlth Serv, Haifa, Israel.
   [Aizenbud, Dror; Levy, Yishai] Rambam Hlth Care Campus, Haifa, Israel.
C3 Technion Israel Institute of Technology; Rappaport Faculty of Medicine;
   Clalit Health Services; Rambam Health Care Campus
RP Levy, Y (corresponding author), Rambam Hlth Care Campus, Dept Med D, POB 31096, Haifa, Israel.
EM ys_levy@rambam.health.gov.il
FU Rappaport Institute for Research; Krol Foundation of Barnegat, NJ;
   Research and Scholarships Fund in Food and Nutrition Fields with Public
   Health Implication; Myers-JDC Brookdale Institute of Gerontology and
   Human Development; Eshel-the Association for the Planning and
   Development of Services for the Aged in Israel
FX We thank the Kibbutz medical staff, Yoke Roded, Smadar Lustgarten, and
   Hannah Shulami, for their outstanding assistance. This work was
   supported by the Rappaport Institute for Research; the Krol Foundation
   of Barnegat, NJ; Research and Scholarships Fund in Food and Nutrition
   Fields with Public Health Implication; and the Myers-JDC Brookdale
   Institute of Gerontology and Human Development and Eshel-the Association
   for the Planning and Development of Services for the Aged in Israel.
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NR 60
TC 12
Z9 12
U1 0
U2 6
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1549-1684
EI 1557-8577
J9 REJUV RES
JI Rejuv. Res.
PD AUG
PY 2014
VL 17
IS 4
BP 334
EP 340
DI 10.1089/rej.2013.1540
PG 7
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA AO0RF
UT WOS:000341018400003
PM 24617844
DA 2025-06-11
ER

PT J
AU Panzhinskiy, E
   Hua, Y
   Culver, B
   Ren, J
   Nair, S
AF Panzhinskiy, E.
   Hua, Y.
   Culver, B.
   Ren, J.
   Nair, S.
TI Endoplasmic reticulum stress upregulates protein tyrosine phosphatase 1B
   and impairs glucose uptake in cultured myotubes
SO DIABETOLOGIA
LA English
DT Article
DE Diabetes; Endoplasmic reticulum stress; Insulin resistance; Obesity;
   Protein tyrosine phosphatase 1B; Tunicamycin
ID LIVER-SPECIFIC DELETION; INSULIN SENSITIVITY; ER STRESS;
   TAUROURSODEOXYCHOLIC ACID; CHEMICAL CHAPERONES; METABOLIC SYNDROME;
   OBESITY; EXPRESSION; ACTIVATION; INFLAMMATION
AB Endoplasmic reticulum (ER) stress has been recognised as a common pathway in the development of obesity-associated insulin resistance. Protein tyrosine phosphatase 1B (PTP1B) is a negative regulator of insulin signalling and is localised on the ER membrane. The aim of the study was to investigate the cross-talk between ER stress and PTP1B.
   Leptin-deficient obese (ob/ob), Ptp1b (also known as Ptpn1) knockout and C57BL/6J mice were subjected to a high-fat or normal-chow diet for 20 weeks. ER stress was induced in cultured myotubes by treatment with tunicamycin. Immunohistochemistry and western blotting were used to assess proteins involved in the ER stress response. Myotube glucose uptake was determined by measuring 2-deoxy[H-3]glucose incorporation.
   A high-fat diet induced ER stress and PTP1B expression in the muscle tissue of mice and these responses were attenuated by treatment with the ER chaperone tauroursodeoxycholic acid (TUDCA). Cultured myotubes exhibited increased levels of PTP1B in response to tunicamycin treatment. Silencing of Ptp1b with small interfering RNA (siRNA) or overexpression of Ptp1b with adenovirus construct failed to alter the levels of ER stress. Ptp1b knockout mice did not differ from the wild-type mice in the extent of tunicamycin-induced upregulation of glucose-regulated protein-78. However, tunicamycin-induced phosphorylation of eukaryotic initiation factor 2 alpha and c-Jun NH2-terminal kinase-2 were significantly attenuated in the Ptp1b knockout mice. Treatment with TUDCA or silencing of PTP1B reversed tunicamycin-induced blunted myotube glucose uptake.
   Our data suggest that PTP1B is activated by ER stress and is required for full-range activation of ER stress pathways in mediating insulin resistance in the skeletal muscle.
C1 [Panzhinskiy, E.; Hua, Y.; Culver, B.; Ren, J.; Nair, S.] Univ Wyoming, Sch Pharm, Coll Hlth Sci, Laramie, WY 82071 USA.
   [Panzhinskiy, E.; Hua, Y.; Culver, B.; Ren, J.; Nair, S.] Univ Wyoming, Ctr Cardiovasc Res & Alternat Med, Laramie, WY 82071 USA.
C3 University of Wyoming; University of Wyoming
RP Nair, S (corresponding author), Univ Wyoming, Sch Pharm, Coll Hlth Sci, Laramie, WY 82071 USA.
EM sreejay@uwyo.edu
RI Ren, Jun/ACG-5366-2022
OI Ren, Jun/0000-0002-0275-0783
FU NIH [P20RR016474]
FX This work was supported in part by grants from NIH P20RR016474 (S. Nair,
   J. Ren).
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NR 44
TC 69
Z9 78
U1 0
U2 14
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0012-186X
EI 1432-0428
J9 DIABETOLOGIA
JI Diabetologia
PD MAR
PY 2013
VL 56
IS 3
BP 598
EP 607
DI 10.1007/s00125-012-2782-z
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 084IH
UT WOS:000314531700019
PM 23178931
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Huang, CW
   Hong, TW
   Wang, YJ
   Chen, KC
   Pei, JC
   Chuang, TY
   Lai, WS
   Tsai, SH
   Chu, R
   Chen, WC
   Sheen, LY
   Takahashi, S
   Ding, ST
   Shen, TL
AF Huang, Chao-Wei
   Hong, Tzu-Wen
   Wang, Ying-Jing
   Chen, Ko-Chien
   Pei, Ju-Chun
   Chuang, Tai-Yuan
   Lai, Wen-Sung
   Tsai, Sheng-Hong
   Chu, Richard
   Chen, Wei-Cheng
   Sheen, Lee-Yan
   Takahashi, Satoru
   Ding, Shih-Torng
   Shen, Tang-Long
TI Ophiocordyceps formosana improves hyperglycemia and
   depression-like behavior in an STZ-induced diabetic mouse model
SO BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Article
DE Ophiocordyceps formosana; Insulin insensitivity; Depression
ID TAIL-SUSPENSION TEST; MAJOR DEPRESSION; ANTIDEPRESSANT MEDICATION; BRAIN
   NOREPINEPHRINE; INSULIN SENSITIVITY; CORDYCEPS-SINENSIS; METABOLIC
   SYNDROME; DOPAMINE RELEASE; GLYCEMIC CONTROL; ADIPOSE-TISSUE
AB Background: A newly defined Cordyceps species, Ophiocordyceps formosana (O. formosana) has been implicated in multitudinous bioactivities, including lowering glucose and cholesterol levels and modulating the immune system. However, few literatures demonstrate sufficient evidence to support these proposed functions. Although the use of Cordyceps spp. has been previously addressed to improve insulin insensitivity and improve the detrimental symptoms of depression; its mechanistic nature remains unsettled. Herein, we reveal the effects of O. formosana in ameliorating hyperglycemia accompanied with depression.
   Methods: Diabetes was induced in mice by employing streptozotocin(STZ), a chemical that is toxic to insulin-producing beta cells of the pancreas. These streptozotocin (STZ)-induced diabetic mice showed combined symptoms of hyperglycemia and depressive behaviors. Twenty-four STZ-induced mice were randomly divided into 3 groups subjected to oral gavage with 100 mu L solution of either PBS or 25 mg/mL Ophiocordyceps formosana extract (OFE) or 2 mg/mL rosiglitazone (Rosi, positive control group). Treatments were administered once per day for 28 days. An additional 6 mice without STZ induction were treated with PBS to serve as the control group. Insulin sensitivity was measured by a glucose tolerance test and levels of adiponectin in plasma and adipose tissue were also quantified. Behavioral tests were conducted and levels of monoamines in various brain regions relating to depression were evaluated.
   Results: HPLC analysis uncovered three major constituents, adenosine, D-mannitol and cordycepin, within O. formosana similar to other prestigious medicinal Cordyceps spp.. STZ-induced diabetic mice demonstrated decreased body weight and subcutaneous adipose tissue, while these symptoms were recovered in mice receiving OFE treatment. Moreover, the OFE group displayed improved insulin sensitivity and elevated adiponectin within the plasma and adipose tissue. The anti-depressive effect of OFE was observed in various depression-related behavior tests. Concurrently, neurotransmitters, like 5-HT and dopamine in the frontal cortex, striatum and hippocampus were found to be up-regulated in OFE-treated mice.
   Conclusions: Our findings illustrated, for the first time, the medicinal merits of O. formosana on Type I diabetes and hyperglycemia-induced depression. OFE were found to promote the expression of adiponectin, which is an adipokine involved in insulin sensitivity and hold anti-depressive effects. In addition, OFE administration also displayed altered levels of neurotransmitters in certain brain regions that may have contributed to its anti-depressive effect. Collectively, this current study provided insights to the potential therapeutic effects of O. formosana extracts in regards to hyperglycemia and its depressive complications.
C1 [Huang, Chao-Wei; Ding, Shih-Torng] Natl Taiwan Univ, Dept Anim Sci & Technol, Taipei 10617, Taiwan.
   [Hong, Tzu-Wen; Tsai, Sheng-Hong; Chu, Richard] Mucho Biotechnol Inc, Taipei 10684, Taiwan.
   [Wang, Ying-Jing; Chen, Ko-Chien; Shen, Tang-Long] Natl Taiwan Univ, Dept Plant Pathol & Microbiol, Taipei 10617, Taiwan.
   [Pei, Ju-Chun; Lai, Wen-Sung] Natl Taiwan Univ, Dept Psychol, Taipei 10617, Taiwan.
   [Chuang, Tai-Yuan] Natl Taiwan Univ, Dept Athlet, Taipei 10617, Taiwan.
   [Ding, Shih-Torng; Shen, Tang-Long] Natl Taiwan Univ, Inst Biotechnol, Taipei 10617, Taiwan.
   [Chen, Wei-Cheng; Sheen, Lee-Yan] Natl Taiwan Univ, Inst Food Sci & Technol, Taipei 10617, Taiwan.
   [Takahashi, Satoru] Univ Tsukuba, Grad Sch Comprehens Human Sci, 1-1-1 Tennodai, Tsukuba, Ibaraki 3058575, Japan.
C3 National Taiwan University; National Taiwan University; National Taiwan
   University; National Taiwan University; National Taiwan University;
   National Taiwan University; University of Tsukuba
RP Ding, ST (corresponding author), Natl Taiwan Univ, Dept Anim Sci & Technol, Taipei 10617, Taiwan.; Shen, TL (corresponding author), Natl Taiwan Univ, Dept Plant Pathol & Microbiol, Taipei 10617, Taiwan.; Ding, ST; Shen, TL (corresponding author), Natl Taiwan Univ, Inst Biotechnol, Taipei 10617, Taiwan.
EM sding@ntu.edu.tw; shentl@ntu.edu.tw
RI Huang, Chao/AAK-3228-2020; Shen, Tang-Long/C-7460-2011; Hong,
   Tzuwen/JXL-6771-2024; Pei, Ju-Chun/V-3714-2017; Chen,
   Wen-Cheng/C-8774-2009; Wang, Yingjie/GQY-6218-2022
OI Shen, Tang-Long/0000-0001-6264-3608; Hong, Tzu-Wen/0000-0003-2956-9607;
   Chen, Ko-Chien/0000-0001-5480-3683
FU Mucho Biotech. Inc.
FX This work was supported by Mucho Biotech. Inc.
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NR 65
TC 21
Z9 23
U1 2
U2 24
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1472-6882
J9 BMC COMPLEM ALTERN M
JI BMC Complement. Altern. Med.
PD AUG 24
PY 2016
VL 16
AR 310
DI 10.1186/s12906-016-1278-7
PG 11
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA DU4TQ
UT WOS:000382205900003
PM 27553852
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Pérez-Torres, I
   Guarner-Lans, V
   Rubio-Ruiz, ME
AF Perez-Torres, Israel
   Guarner-Lans, Veronica
   Esther Rubio-Ruiz, Maria
TI Reductive Stress in Inflammation-Associated Diseases and the Pro-Oxidant
   Effect of Antioxidant Agents
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE reductive stress; antioxidants; reducing equivalents; inflammation;
   pro-oxidants
ID NF-KAPPA-B; CHAIN-BREAKING ANTIOXIDANT; OXIDATIVE STRESS; VITAMIN-E;
   BUTYLATED HYDROXYTOLUENE; GLUTATHIONE-PEROXIDASE;
   MITOCHONDRIAL-FUNCTION; INSULIN-RESISTANCE; LIPID-PEROXIDATION;
   BETA-CAROTENE
AB Reductive stress (RS) is the counterpart oxidative stress (OS), and can occur in response to conditions that shift the redox balance of important biological redox couples, such as the NAD(+)/NADH, NADP(+)/NADPH, and GSH/GSSG, to a more reducing state. Overexpression of antioxidant enzymatic systems leads to excess reducing equivalents that can deplete reactive oxidative species, driving the cells to RS. A feedback regulation is established in which chronic RS induces OS, which in turn, stimulates again RS. Excess reducing equivalents may regulate cellular signaling pathways, modify transcriptional activity, induce alterations in the formation of disulfide bonds in proteins, reduce mitochondrial function, decrease cellular metabolism, and thus, contribute to the development of some diseases in which NF-kappa B, a redox-sensitive transcription factor, participates. Here, we described the diseases in which an inflammatory condition is associated to RS, and where delayed folding, disordered transport, failed oxidation, and aggregation are found. Some of these diseases are aggregation protein cardiomyopathy, hypertrophic cardiomyopathy, muscular dystrophy, pulmonary hypertension, rheumatoid arthritis, Alzheimer's disease, and metabolic syndrome, among others. Moreover, chronic consumption of antioxidant supplements, such as vitamins and/or flavonoids, may have pro-oxidant effects that may alter the redox cellular equilibrium and contribute to RS, even diminishing life expectancy.
C1 [Perez-Torres, Israel] Inst Nacl Cardiol Ignacio Chavez, Dept Pathol, Juan Badiano 1,Secc 16, Mexico City 14080, DF, Mexico.
   [Guarner-Lans, Veronica; Esther Rubio-Ruiz, Maria] Inst Nacl Cardiol Ignacio Chavez, Dept Physiol, Juan Badiano 1,Secc 16, Mexico City 14080, DF, Mexico.
C3 National Institute of Cardiology - Mexico; National Institute of
   Cardiology - Mexico
RP Pérez-Torres, I (corresponding author), Inst Nacl Cardiol Ignacio Chavez, Dept Pathol, Juan Badiano 1,Secc 16, Mexico City 14080, DF, Mexico.
EM Israel.perez@cardiologia.org.mx
RI Pérez Torres, Israel/AAE-2579-2022; Guarner-Lans, Verónica/AFW-3723-2022
OI Rubio-Ruiz, Maria Esther/0000-0002-8844-2078; Perez-Torres,
   Israel/0000-0001-6510-2954; Guarner-Lans, Veronica/0000-0002-2655-7590
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NR 186
TC 184
Z9 203
U1 3
U2 26
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD OCT
PY 2017
VL 18
IS 10
AR 2098
DI 10.3390/ijms18102098
PG 26
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA FM0QL
UT WOS:000414671800082
PM 28981461
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Lee, HK
   Nam, YH
   Shin, SW
   Kim, MC
   An, JI
   Kim, NW
   Shim, JH
   Srinath, S
   Hong, BN
   Kwak, JH
   Kang, TH
AF Lee, Hyo Kyu
   Nam, Youn Hee
   Shin, Sung Woo
   Kim, Min Cheol
   An, Jung In
   Kim, Na Woo
   Shim, Ji Heon
   Srinath, Sunitha
   Hong, Bin Na
   Kwak, Jong Hwan
   Kang, Tong Ho
TI Erigeron annuus Extract Alleviates Insulin Resistance via
   Regulating the Expression of Mitochondrial Damage and Endoplasmic
   Reticulum Stress-Related Genes
SO NUTRIENTS
LA English
DT Article
DE Erigeron annuus; insulin resistance; zebrafish; mitochondrial damage;
   endoplasmic reticulum stress
ID ER STRESS; LINKS MITOCHONDRIAL; METABOLIC SYNDROME; CHLOROGENIC ACIDS;
   BLOOD-PRESSURE; GLUCOSE; DYSFUNCTION; OXIDASE; COFFEE; PIOGLITAZONE
AB Diabetes is a prevalent and debilitating metabolic disorder affecting a large population worldwide. The condition is characterized by insulin resistance and impaired function of pancreatic & beta;-cells, leading to elevated blood glucose levels. In this study, the antidiabetic effects of Erigeron annuus extract (EAE) on zebrafish with damaged pancreatic islets caused by insulin resistance were investigated. The study utilized the zebrafish model to monitor live pancreatic islets. RNA sequencing was also conducted to determine the mechanism by which EAE exerts its antidiabetic effect. The results showed that EAE was effective in recovering reduced islets in excess insulin-induced zebrafish. The effective concentration at 50% (EC50) of EAE was determined to be 0.54 & mu;g/mL, while the lethal concentration at 50% (LC50) was calculated as 202.5 & mu;g/mL. RNA sequencing indicated that the mode of action of EAE is related to its ability to induce mitochondrial damage and suppress endoplasmic reticulum stress. The findings of this study demonstrate the efficacy and therapeutic potential of EAE in treating insulin resistance in zebrafish. The results suggest that EAE may offer a promising approach for the management of diabetes by reducing mitochondrial damage and suppressing endoplasmic reticulum stress. Further research is required to establish the clinical application of EAE in diabetic patients.
C1 [Lee, Hyo Kyu; Nam, Youn Hee; Shin, Sung Woo; Kim, Min Cheol; Kim, Na Woo; Shim, Ji Heon; Srinath, Sunitha; Hong, Bin Na; Kang, Tong Ho] Kyung Hee Univ, Coll Life Sci, Dept Oriental Med Biotechnol, Global Campus, Yongin 17104, Gyeonggi Do, South Korea.
   [Lee, Hyo Kyu; Nam, Youn Hee; Shin, Sung Woo; Kim, Min Cheol; Kim, Na Woo; Shim, Ji Heon; Srinath, Sunitha; Hong, Bin Na; Kang, Tong Ho] Kyung Hee Univ, Grad Sch Biotechnol, Global Campus, Yongin 17104, Gyeonggi Do, South Korea.
   [An, Jung In; Kwak, Jong Hwan] Sungkyunkwan Univ, Sch Pharm, Suwon 16419, Gyeonggi Do, South Korea.
C3 Kyung Hee University; Kyung Hee University; Sungkyunkwan University
   (SKKU)
RP Kang, TH (corresponding author), Kyung Hee Univ, Coll Life Sci, Dept Oriental Med Biotechnol, Global Campus, Yongin 17104, Gyeonggi Do, South Korea.; Kang, TH (corresponding author), Kyung Hee Univ, Grad Sch Biotechnol, Global Campus, Yongin 17104, Gyeonggi Do, South Korea.
EM panjae@khu.ac.kr
RI Srinath, Sanyadanam/S-1723-2018
OI Shin, Sung Woo/0000-0003-1038-3749
FU Technology Development Program - Ministry of SMEs and Startups (MSS,
   Republic of Korea) [S3033322]; Ministry of SMEs and Startups (MSS,
   Republic of Korea)
FX This work was supported by the Technology Development Program (S3033322)
   funded by the Ministry of SMEs and Startups (MSS, Republic of Korea).
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NR 49
TC 1
Z9 1
U1 1
U2 5
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JUN
PY 2023
VL 15
IS 12
AR 2685
DI 10.3390/nu15122685
PG 15
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA K5XX7
UT WOS:001017180400001
PM 37375588
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Sinha, JK
   Ghosh, S
   Swain, U
   Giridharan, NV
   Raghunath, M
AF Sinha, J. K.
   Ghosh, S.
   Swain, U.
   Giridharan, N. V.
   Raghunath, M.
TI INCREASED MACROMOLECULAR DAMAGE DUE TO OXIDATIVE STRESS IN THE NEOCORTEX
   AND HIPPOCAMPUS OF WNIN/OB, A NOVEL RAT MODEL OF PREMATURE AGING
SO NEUROSCIENCE
LA English
DT Article
DE antioxidant enzyme activity; brain aging; comet assay; DNA damage;
   obesity; reduced lifespan
ID BINGE-EATING DISORDER; ANTIOXIDANT ENZYME-ACTIVITY; DNA-DAMAGE;
   NEUROTROPHIC FACTOR; BRAIN; OBESITY; AGE; ASSAY; PEROXIDATION;
   COMORBIDITY
AB Wistar of the National Institute of Nutrition obese (WNIN/Ob) is a unique rat strain isolated and established at NIN, Hyderabad, India, in 1996, from its existing stock of Wistar rat colony (WNIN). This animal model exhibits all traits of metabolic syndrome and has a remarkably reduced lifespan (1.5 years as compared to 3 years in parental WNIN rats), albeit, the factors associated with premature aging are not well understood. Considering that oxidative stress and DNA damage are crucial players associated with senescence, we analyzed oxidative stress markers like lipid peroxidation and protein oxidation; DNA damage in terms of both single-stranded and double-stranded breaks and the activity of antioxidant enzymes: superoxide dismutase and catalase in brain regions of these animals. Our study revealed that the magnitude of oxidative stress and DNA damage in the neocortex and hippocampus of 3-month-old WNIN/Ob obese rats is as high as that seen in 15-month-old parental WNIN control rats. Concurrently, the antioxidant enzyme activity was significantly decreased. From these results, it can be concluded that increased oxidative stress-induced damage of macromolecules, probably due to reduced activity of antioxidant enzymes, is associated with premature aging in WNIN/Ob obese rats. (C) 2014 IBRO. Published by Elsevier Ltd. All rights reserved.
C1 [Sinha, J. K.; Ghosh, S.; Raghunath, M.] NIN, Hyderabad 500007, Andhra Pradesh, India.
   [Swain, U.] JNTU, Hyderabad 500085, Andhra Pradesh, India.
   [Giridharan, N. V.] NIN, Natl Ctr Lab Anim Sci, Hyderabad 500007, Andhra Pradesh, India.
C3 Indian Council of Medical Research (ICMR); ICMR - National Institute of
   Nutrition (NIN); Jawaharlal Nehru Technological University - Hyderabad;
   Indian Council of Medical Research (ICMR); ICMR - National Animal
   Resource Facility for Biomedical Research (NARFBR); ICMR - National
   Institute of Nutrition (NIN)
RP Raghunath, M (corresponding author), NIN, Div Endocrinol & Metab, Hyderabad 500007, Andhra Pradesh, India.
EM jitendrakumarsinha@gmail.com; g.shampa17@gmail.com; uswain@gmail.com;
   nappanveettil@yahoo.co.in; mraghunath55@yahoo.com
RI Ghosh, Shampa/G-4237-2012; Swain, Umakanta/AAB-6295-2020; Sinha,
   Jitendra Kumar/G-1084-2012
OI Sinha, Jitendra Kumar/0000-0002-7444-6932; Swain,
   Umakanta/0000-0002-3563-2433; Ghosh, Shampa/0000-0002-3252-7216
FU Indian Council of Medical Research (ICMR), Government of India;
   International Brain Research Organization (IBRO)
FX We acknowledge Indian Council of Medical Research (ICMR), Government of
   India for funding the study and awarding Senior Research Fellowships to
   JKS & SG; International Brain Research Organization (IBRO) for awarding
   fellowships under Young Investigator Program to JKS & SG. We thank Mrs.
   S. Bhagyalakshmi for assistance in maintaining animals, preparation of
   reagents and running assays.
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NR 55
TC 39
Z9 42
U1 0
U2 12
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4522
EI 1873-7544
J9 NEUROSCIENCE
JI Neuroscience
PD JUN 6
PY 2014
VL 269
BP 256
EP 264
DI 10.1016/j.neuroscience.2014.03.040
PG 9
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA AH1TL
UT WOS:000335903900024
PM 24709042
DA 2025-06-11
ER

PT J
AU Mather, KJ
AF Mather, Kieren J.
TI The vascular endothelium in diabetes-a therapeutic target?
SO REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
LA English
DT Article
DE Insulin; Vasodilation; Endothelium; Nitric oxide; Endothelin; Therapy
ID NECROSIS-FACTOR-ALPHA; NITRIC-OXIDE SYNTHASE; GLYCATION END-PRODUCTS;
   LIPOPROTEIN CHOLESTEROL LEVELS; ENDOPLASMIC-RETICULUM STRESS; IMPROVES
   INSULIN SENSITIVITY; CORONARY-ARTERY-DISEASE; GREEN TEA CONSUMPTION;
   C-REACTIVE-PROTEIN; TNF-ALPHA
AB Insulin resistance affects the vascular endothelium, and contributes to systemic insulin resistance by directly impairing the actions of insulin to redistribute blood flow as part of its normal actions driving muscle glucose uptake. Impaired vascular function is a component of the insulin resistance syndrome, and is a feature of type 2 diabetes. On this basis, the vascular endothelium has emerged as a therapeutic target where the intent is to improve systemic metabolic state by improving vascular function. We review the available literature presenting studies in humans, evaluating the effects of metabolically targeted and vascular targeted therapies on insulin action and systemic metabolism. Therapies that improve systemic insulin resistance exert strong concurrent effects to improve vascular function and vascular insulin action. RAS-acting agents and statins have widely recognized beneficial effects on vascular function but have not uniformly produced the hoped-for metabolic benefits. These observations support the notion that systemic metabolic benefits can arise from therapies targeted at the endothelium, but improving vascular insulin action does not result from all treatments that improve endothelium-dependent vasodilation. A better understanding of the mechanisms of insulin's actions in the vascular wall will advance our understanding of the specificity of these responses, and allow us to better target the vasculature for metabolic benefits.
C1 Indiana Univ Sch Med, Indianapolis, IN 46202 USA.
C3 Indiana University System; Indiana University Bloomington
RP Mather, KJ (corresponding author), Indiana Univ Sch Med, 541 North Barnhill Dr,Suite CL365, Indianapolis, IN 46202 USA.
EM kmather@iu.edu
RI Mather, Kieren/ABE-4117-2020; Stefanadis, Christodoulos/ABH-2232-2020
OI Stefanadis, Christodoulos/0000-0001-5974-6454
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NR 194
TC 37
Z9 42
U1 0
U2 8
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1389-9155
EI 1573-2606
J9 REV ENDOCR METAB DIS
JI Rev. Endocr. Metab. Disord.
PD MAR
PY 2013
VL 14
IS 1
BP 87
EP 99
DI 10.1007/s11154-013-9237-9
PG 13
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 098SC
UT WOS:000315568000011
PM 23397462
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Eliades, M
   Spyrou, E
AF Eliades, Myrto
   Spyrou, Elias
TI Vitamin D: a new player in non-alcoholic fatty liver disease?
SO WORLD JOURNAL OF GASTROENTEROLOGY
LA English
DT Article
DE Steatohepatitis; Non-alcoholic fatty liver disease; Fatty liver; Vitamin
   D
ID INSULIN-RECEPTOR GENE; DENDRITIC CELLS; ADIPOSE-TISSUE; OXIDATIVE
   STRESS; D DEFICIENCY; INFLAMMATORY BIOMARKERS; 25-HYDROXYVITAMIN D-3;
   HEPATIC STEATOSIS; NUCLEAR RECEPTOR; GUT MICROBIOTA
AB Vitamin D through its active form 1a-25-dihydroxyvtamin D [1,25(OH)(2)D] is a secosteroid hormone that plays a key role in mineral metabolism. Recent years have witnessed a significant scientific interest on vitamin D and expanded its actions to include immune modulation, cell differentiation and proliferation and inflammation regulation. As our understanding of the many functions of vitamin D has grown, the presence of vitamin D deficiency has become one of the most prevalent micronutrient deficiencies worldwide. Concomitantly, non-alcoholic fatty liver disease (NAFLD) has become the most common form of chronic liver disease in western countries. NAFLD and vitamin D deficiency often coexist and epidemiologic evidence has shown that both of these conditions share several cardiometabolic risk factors. In this article we provide an overview of the epidemiology and pathophysiology linking NAFLD and vitamin D deficiency, as well as the available evidence on the clinical utility of vitamin D supplementation in NAFLD.
C1 [Eliades, Myrto] Univ Maryland, Sch Med, Div Endocrinol Diabet & Nutr, Baltimore, MD 21201 USA.
   [Spyrou, Elias] Medstar Washington Hosp Ctr, Dept Internal Med, Washington, DC 20010 USA.
C3 University System of Maryland; University of Maryland Baltimore; MedStar
   Washington Hospital Center
RP Eliades, M (corresponding author), Univ Maryland, Sch Med, Div Endocrinol Diabet & Nutr, 660 W Redwood St,HH 496, Baltimore, MD 21201 USA.
EM meliades@medicine.umaryland.edu
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NR 87
TC 124
Z9 135
U1 0
U2 25
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 8226 REGENCY DR, PLEASANTON, CA 94588 USA
SN 1007-9327
EI 2219-2840
J9 WORLD J GASTROENTERO
JI World J. Gastroenterol.
PD FEB 14
PY 2015
VL 21
IS 6
BP 1718
EP 1727
DI 10.3748/wjg.v21.i6.1718
PG 10
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA CB5KQ
UT WOS:000349666300004
PM 25684936
OA Green Published, hybrid, Green Submitted
DA 2025-06-11
ER

PT J
AU Raman, G
   Avendano, EE
   Chen, SY
   Wang, JQ
   Matson, J
   Gayer, B
   Novotny, JA
   Cassidy, A
AF Raman, Gowri
   Avendano, Esther E.
   Chen, Siyu
   Wang, Jiaqi
   Matson, Julia
   Gayer, Bridget
   Novotny, Janet A.
   Cassidy, Aedin
TI Dietary intakes of flavan-3-ols and cardiometabolic health: systematic
   review and meta-analysis of randomized trials and prospective cohort
   studies
SO AMERICAN JOURNAL OF CLINICAL NUTRITION
LA English
DT Review
DE flavan-3-ols; flavonoids; cardiovascular; diabetes; blood pressure
ID CARDIOVASCULAR-DISEASE MORTALITY; ISCHEMIC-HEART-DISEASE; FLAVONOID
   INTAKE; TEA CONSUMPTION; RACIAL-DIFFERENCES; POLYPHENOL INTAKE; VASCULAR
   FUNCTION; OXIDATIVE STRESS; RICH COCOA; CVD RISK
AB Background: Although available data suggest that some dietary flavan-3-ol sources reduce cardiometabolic risk, to our knowledge no review has systematically synthesized their specific contribution.
   Objective: We aimed to examine, for the first time, if there is consistent evidence that higher flavan-3-ol intake, irrespective of dietary source, reduces cardiometabolic risk.
   Methods: MEDLINE, Cochrane Central, and Commonwealth Agricultural Bureau abstracts were searched for prospective cohorts and randomized controlled trials (RCTs) published from 1946 to March 2019 on flavan-3-ol intake and cardiovascular disease (CVD) risk. Random-effects models meta-analysis was used. The Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach assessed the strength of evidence.
   Results: Of 15 prospective cohorts (23 publications), 4 found highest compared with lowest habitual intakes of flavan-3-ols were associated with a 13% reduction in risk of CVD mortality and 2 found a 19% reduction in risk of chronic heart disease (CHD) incidence. Highest compared with lowest habitual intakes of monomers were associated with a reduction in risk of type 2 diabetes mellitus (T2DM) (n = 5) and stroke (n = 4) (10% and 18%, respectively). No association was found for hypertension. Of 156 RCTs, flavan-3-ol intervention resulted in significant improvements in acute/chronic flow-mediated dilation (FMD), systolic (SBP) and diastolic blood pressure (DBP), total cholesterol (TC), LDL and HDL cholesterol, triglycerides (TGs), hemoglobin A1c (HbA1c), and homeostasis model assessment of insulin resistance (HOMA-IR). All analyses, except HbA1c, were associated with moderate/high heterogeneity. When analyses were limited to good methodological quality studies, improvements in TC, HDL cholesterol, SBP, DBP, HOMA-IR, and acute/chronic FMD remained significant. In GRADE evaluations, there was moderate evidence in cohort studies that flavan-3-ol and monomer intakes were associated with reduced risk of CVD mortality, CHD, stroke, and T2DM, whereas RCTs reported improved TC, HDL cholesterol, SBP, and HOMA-IR.
   Conclusions: Available evidence supports a beneficial effect of flavan-3-ol intake on cardiometabolic outcomes, but there was considerable heterogeneity in the meta-analysis. Future research should focus on an integrated intake/biomarker approach in cohorts and high-quality dose-response RCTs.
C1 [Raman, Gowri; Avendano, Esther E.; Chen, Siyu; Wang, Jiaqi; Gayer, Bridget] Tufts Med Ctr, Inst Clin Res & Hlth Policy Studies, Tufts Ctr Clin Evidence Synth, Boston, MA 02111 USA.
   [Chen, Siyu; Wang, Jiaqi; Gayer, Bridget] Tufts Univ, Friedman Sch Nutr Sci & Policy, Boston, MA 02111 USA.
   [Matson, Julia] Brandeis Univ, Dept Biol, Waltham, MA 02254 USA.
   [Novotny, Janet A.] ARS, Beltsville Human Nutr Res Ctr, USDA, Beltsville, MD USA.
   [Cassidy, Aedin] Queens Univ Belfast, Inst Global Food Secur, Belfast, Antrim, North Ireland.
C3 Tufts Medical Center; Tufts University; Brandeis University; United
   States Department of Agriculture (USDA); Queens University Belfast
RP Raman, G (corresponding author), Tufts Med Ctr, Inst Clin Res & Hlth Policy Studies, Tufts Ctr Clin Evidence Synth, Boston, MA 02111 USA.
EM graman@tuftsmedicalcenter.org
RI wang, jiaqi/HGF-2290-2022; Chen, Siyu/HLW-0896-2023
OI Raman, Gowri/0000-0003-4427-1083
FU International Life Sciences Institute North America
FX Supported by International Life Sciences Institute North America.
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NR 56
TC 70
Z9 71
U1 2
U2 23
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0002-9165
EI 1938-3207
J9 AM J CLIN NUTR
JI Am. J. Clin. Nutr.
PD NOV
PY 2019
VL 110
IS 5
BP 1067
EP 1078
DI 10.1093/ajcn/nqz178
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA JY0CQ
UT WOS:000504093300008
PM 31504087
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Bosch-Sierra, N
   Valle, CGD
   Salom, C
   Zaragoza-Villena, B
   Perea-Galera, L
   Falcón-Tapiador, R
   Rovira-Llopis, S
   Morillas, C
   Monleon, D
   Bañuls, C
AF Bosch-Sierra, Neus
   Grau-del Valle, Carmen
   Salom, Christian
   Zaragoza-Villena, Begona
   Perea-Galera, Laura
   Falcon-Tapiador, Rosa
   Rovira-Llopis, Susana
   Morillas, Carlos
   Monleon, Daniel
   Banuls, Celia
TI Effect of a Very Low-Calorie Diet on Oxidative Stress, Inflammatory and
   Metabolomic Profile in Metabolically Healthy and Unhealthy Obese
   Subjects
SO ANTIOXIDANTS
LA English
DT Article
DE obesity; weight loss; metabolic syndrome; oxidative stress;
   inflammation; metabolome; amino acids; lipid moieties
ID CHAIN AMINO-ACIDS; WEIGHT-LOSS; TAURINE SUPPLEMENTATION; KETO-ACIDS;
   RESTRICTION; INDIVIDUALS; OVERWEIGHT; RESISTANCE; LEUKOCYTES; DAMAGE
AB The purpose of the study was to determine the impact of weight loss through calorie restriction on metabolic profile, and inflammatory and oxidative stress parameters in metabolically healthy (MHO) and unhealthy (MUHO) obese individuals. A total of 74 subjects (34 MHO and 40 MUHO) received two cycles of a very low-calorie diet, alternating with a hypocaloric diet for 24 weeks. Biochemical, oxidative stress, and inflammatory markers, as well as serum metabolomic analysis by nuclear magnetic resonance, were performed at baseline and at the end of the intervention. After the diet, there was an improvement in insulin resistance, as well as a significant decrease in inflammatory parameters, enhancing oxidative damage, mitochondrial membrane potential, glutathione, and antioxidant capacity. This improvement was more significant in the MUHO group. The metabolomic analysis showed a healthier profile in lipoprotein profile. Lipid carbonyls also decrease at the same time as unsaturated fatty acids increase. We also display a small decrease in succinate, glycA, alanine, and BCAAs (valine and isoleucine), and a slight increase in taurine. These findings show that moderate weight reduction leads to an improvement in lipid profile and subfractions and a reduction in oxidative stress and inflammatory markers; these changes are more pronounced in the MUHO population.
C1 [Bosch-Sierra, Neus; Grau-del Valle, Carmen; Salom, Christian; Zaragoza-Villena, Begona; Perea-Galera, Laura; Falcon-Tapiador, Rosa; Rovira-Llopis, Susana; Morillas, Carlos; Banuls, Celia] Univ Hosp Doctor Peset, Fdn Promot Hlth & Biomed Res Valencian Reg FISABIO, Dept Endocrinol & Nutr, Valencia 46017, Spain.
   [Rovira-Llopis, Susana] Univ Valencia, INCL Biomed Res Inst, Dept Physiol, Valencia 46010, Spain.
   [Morillas, Carlos] Univ Valencia, Dept Med, Valencia 46010, Spain.
   [Monleon, Daniel] Univ Valencia, INCL Biomed Res Inst, Dept Pathol, Valencia 46010, Spain.
C3 University of Valencia; University of Valencia; University of Valencia
RP Bañuls, C (corresponding author), Univ Hosp Doctor Peset, Fdn Promot Hlth & Biomed Res Valencian Reg FISABIO, Dept Endocrinol & Nutr, Valencia 46017, Spain.; Monleon, D (corresponding author), Univ Valencia, INCL Biomed Res Inst, Dept Pathol, Valencia 46010, Spain.
EM neus.bosch@fisabio.es; graudel89@gmail.com; chsaven@gmail.com;
   begozaragoza1973@gmail.com; laura.perea@fisabio.es;
   rosa.falcon@fisabio.es; susana.rovira@uv.es; carlos.morillas@uv.es;
   daniel.monleon@uv.es; celia.banuls@uv.es
RI Morillas, Carlos/ABF-3504-2020; Banuls, Celia/H-7359-2017; Monleon,
   Daniel/A-5078-2010; Rovira-Llopis, Susana/AAX-8666-2021
OI Morillas, Carlos/0000-0002-3745-4423; Banuls, Celia/0000-0001-8077-7642;
   Monleon, Daniel/0000-0002-4803-1573; Falcon Tapiador, Rosa
   Maria/0000-0003-2866-6333; Perea Galera, Laura/0009-0001-3719-3614;
   Bosch, Neus/0000-0002-7582-4085; Rovira-Llopis,
   Susana/0000-0002-8476-5128
FU Carlos III Health Institute (ISCIII)
FX The authors acknowledge the technical support of Lydia Pelufo
   (University Hospital Doctor Peset-FISABIO).
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NR 60
TC 11
Z9 11
U1 0
U2 3
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD MAR
PY 2024
VL 13
IS 3
AR 302
DI 10.3390/antiox13030302
PG 22
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA MC1V7
UT WOS:001191346300001
PM 38539836
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Watterberg, KL
   Hintz, SR
   Do, B
   Vohr, BR
   Lowe, J
   Newman, JE
   Wallace, D
   Lacy, CB
   Davis, EP
   Granger, DA
   Shankaran, S
   Payne, A
   Higgins, RD
   Jobe, AH
   Caplan, MS
   Polin, RA
   Laptook, AR
   Hensman, AM
   Vieira, E
   Little, E
   Johnson, K
   Alksninis, B
   Keszler, ML
   Knoll, AM
   Leach, TM
   McGowan, EC
   Watson, VE
   Walsh, MC
   Fanaroff, AA
   Wilson-Costello, DE
   Newman, NS
   Siner, BS
   Zadell, A
   DiFiore, J
   Bhola, M
   Friedman, HG
   Yalcinkaya, G
   Goldberg, RN
   Cotten, CM
   Gustafson, KE
   Goldstein, RF
   Ashley, P
   Auten, KJ
   Fisher, KA
   Foy, KA
   Freedman, SF
   Lohmeyer, MB
   Malcolm, WF
   Wallace, DK
   Carlton, DP
   Stoll, BJ
   Adams-Chapman, I
   Buchter, S
   Piazza, AJ
   Carter, S
   Fritz, S
   Hale, EC
   Hutchinson, AK
   LaRossa, MM
   Loggins, Y
   Bottcher, D
   Archer, SW
   Poindexter, BB
   Sokol, GM
   Harmon, HM
   Papile, LA
   Hines, AC
   Wilson, LD
   Herron, DE
   Smiley, L
   Kennedy, KA
   Tyson, JE
   Duncan, AF
   Dempsey, AG
   John, J
   Jones, PM
   Lillie, ML
   Siddiki, S
   Sperry, DK
   Blaisdell, CJ
   Pemberton, V
   Das, A
   Gantz, MG
   Auman, JO
   Hammond, JA
   Poole, WK
   Van Meurs, KP
   Stevenson, DK
   Ball, MB
   DeAnda, ME
   Goodlin, GT
   Frantz, ID
   Fiascone, JM
   Kurfiss, A
   MacKinnon, BL
   Nylen, E
   Brussa, A
   Sibley, C
   Carlo, WA
   Ambalavanan, N
   Collins, MV
   Cosby, SS
   Phillips, VA
   Domanovich, K
   Whitley, S
   Smith, LA
   Kiser, CR
   Finer, NN
   Garey, D
   Rasmussen, MR
   Wozniak, PR
   Vaucher, YE
   Fuller, MG
   Akshoomoff, N
   Rich, W
   Arnell, K
   Bridge, R
   Bell, EF
   Colaizy, TT
   Widness, JA
   Klein, JM
   Johnson, KJ
   Acarregui, MJ
   Eastman, DL
   Wilgenbusch, TLV
   Ohls, RK
   Fuller, J
   Thomson, RA
   Brown, S
   Sánchez, PJ
   Heyne, RJ
   Rosenfeld, CR
   Salhab, WA
   Brion, L
   Adams, SS
   Allen, J
   Grau, L
   Guzman, A
   Hensley, G
   Heyne, ET
   Hickman, JF
   Lee, LE
   Leps, MH
   Madden, LA
   Martin, MS
   Miller, NA
   Morgan, JS
   Solis, A
   Boatman, CT
   Vasil, DM
   Yoder, BA
   Faix, RG
   Baker, S
   Osborne, KA
   Rau, CA
   Winter, S
   Cunningham, SD
   Ford, AC
   Pappas, A
   Sood, BG
   Bara, R
   Slovis, TL
   Goldston, LA
   Johnson, M
AF Watterberg, Kristi L.
   Hintz, Susan R.
   Do, Barbara
   Vohr, Betty R.
   Lowe, Jean
   Newman, Jamie E.
   Wallace, Dennis
   Lacy, Conra Backstrom
   Davis, Elysia Poggi
   Granger, Douglas A.
   Shankaran, Seetha
   Payne, Allison
   Higgins, Rosemary D.
   Jobe, Alan H.
   Caplan, Michael S.
   Polin, Richard A.
   Laptook, Abbot R.
   Hensman, Angelita M.
   Vieira, Elisa
   Little, Emilee
   Johnson, Katharine
   Alksninis, Barbara
   Keszler, Mary Lenore
   Knoll, Andrea M.
   Leach, Theresa M.
   McGowan, Elisabeth C.
   Watson, Victoria E.
   Walsh, Michele C.
   Fanaroff, Avroy A.
   Wilson-Costello, Deanne E.
   Newman, Nancy S.
   Siner, Bonnie S.
   Zadell, Arlene
   DiFiore, Julie
   Bhola, Monika
   Friedman, Harriet G.
   Yalcinkaya, Gulgun
   Goldberg, Ronald N.
   Cotten, C. Michael
   Gustafson, Kathryn E.
   Goldstein, Ricki F.
   Ashley, Patricia
   Auten, Kathy J.
   Fisher, Kimberley A.
   Foy, Katherine A.
   Freedman, Sharon F.
   Lohmeyer, Melody B.
   Malcolm, William F.
   Wallace, David K.
   Carlton, David P.
   Stoll, Barbara J.
   Adams-Chapman, Ira
   Buchter, Susie
   Piazza, Anthony J.
   Carter, Sheena
   Fritz, Sobha
   Hale, Ellen C.
   Hutchinson, Amy K.
   LaRossa, Maureen Mulligan
   Loggins, Yvonne
   Bottcher, Diane
   Archer, Stephanie Wilson
   Poindexter, Brenda B.
   Sokol, Gregory M.
   Harmon, Heidi M.
   Papile, Lu-Ann
   Hines, Abbey C.
   Wilson, Leslie D.
   Herron, Dianne E.
   Smiley, Lucy
   Kennedy, Kathleen A.
   Tyson, Jon E.
   Duncan, Andrea F.
   Dempsey, Allison G.
   John, Janice
   Jones, Patrick M.
   Lillie, M. Layne
   Siddiki, Saba
   Sperry, Daniel K.
   Blaisdell, Carol J.
   Pemberton, Victoria
   Das, Abhik
   Gantz, Marie G.
   Auman, Jeanette O'Donnell
   Hammond, Jane A.
   Poole, W. Kenneth
   Van Meurs, Krisa P.
   Stevenson, David K.
   Ball, M. Bethany
   DeAnda, Maria Elena
   Goodlin, Gabrielle T.
   Frantz, Ivan D., III
   Fiascone, John M.
   Kurfiss, Anne
   MacKinnon, Brenda L.
   Nylen, Ellen
   Brussa, Ana
   Sibley, Cecelia
   Carlo, Waldemar A.
   Ambalavanan, Namasivayam
   Collins, Monica, V
   Cosby, Shirley S.
   Phillips, Vivien A.
   Domanovich, Kristy
   Whitley, Sally
   Smith, Leigh Ann
   Kiser, Carin R.
   Finer, Neil N.
   Garey, Donna
   Rasmussen, Maynard R.
   Wozniak, Paul R.
   Vaucher, Yvonne E.
   Fuller, Martha G.
   Akshoomoff, Natacha
   Rich, Wade
   Arnell, Kathy
   Bridge, Renee
   Bell, Edward F.
   Colaizy, Tarah T.
   Widness, John A.
   Klein, Jonathan M.
   Johnson, Karen J.
   Acarregui, Michael J.
   Eastman, Diane L.
   Wilgenbusch, Tammy L., V
   Ohls, Robin K.
   Fuller, Jane
   Thomson, Rebecca A.
   Brown, Sandra
   Sanchez, Pablo J.
   Heyne, Roy J.
   Rosenfeld, Charles R.
   Salhab, Walid A.
   Brion, Luc
   Adams, Sally S.
   Allen, James
   Grau, Laura
   Guzman, Alicia
   Hensley, Gaynelle
   Heyne, Elizabeth T.
   Hickman, Jackie F.
   Lee, Lizette E.
   Leps, Melissa H.
   Madden, Linda A.
   Martin, Melissa Swensen
   Miller, Nancy A.
   Morgan, Janet S.
   Solis, Araceli
   Boatman, Catherine Twell
   Vasil, Diana M.
   Yoder, Bradley A.
   Faix, Roger G.
   Baker, Shawna
   Osborne, Karen A.
   Rau, Carrie A.
   Winter, Sarah
   Cunningham, Sean D.
   Ford, Ariel C.
   Pappas, Athina
   Sood, Beena G.
   Bara, Rebecca
   Slovis, Thomas L.
   Goldston, Laura A.
   Johnson, Mary
CA Eunice Kennedy Shriver Natl Inst C
   Neonatal Res Network
TI Adrenal function links to early postnatal growth and blood pressure at
   age 6 in children born extremely preterm
SO PEDIATRIC RESEARCH
LA English
DT Article
ID DEHYDROEPIANDROSTERONE-SULFATE; WEIGHT-GAIN; BIRTH; FETAL; CORTISOL;
   SALIVARY; DISEASE; STRESS; PAIN
AB BACKGROUND: Low birth weight in term-born individuals correlates with adverse cardiometabolic outcomes; excess glucocorticoid exposure has been linked to these relationships. We hypothesized that cortisol and adrenal androgens would correlate inversely with birthweight and directly with markers of cardiometabolic risk in school-aged children born extremely preterm; further, preterm-born would have increased cortisol and adrenal androgens compared to term-born children.
   METHODS: Saliva samples were obtained at age 6 from 219 preterm-born children followed since birth and 40 term-born children and analyzed for dehydroepiandrosterone (DHEA) and cortisol. Cortisol was also measured at home (awakening, 30' later, evening).
   RESULTS: For preterm-born children, cortisol and DHEA correlated inversely with weight and length Z-scores at 36 weeks PMA and positively with systolic BP. DHEA was higher in preterm-born than term-born children (boys p < 0.01; girls p = 0.04). Cortisol was similar between preterm-born and term-born at study visit; however, preterm-born children showed a blunted morning cortisol. In term-born children, DHEA correlated with BMI (p = 0.04), subscapular, and abdominal skinfold thicknesses (both p < 0.01).
   CONCLUSION: Cortisol and DHEA correlated inversely with early postnatal growth and directly with systolic BP in extremely preterm-born children, suggesting perinatal programming. Blunted morning cortisol may reflect NICU stress, as seen after other adverse childhood experiences (ACEs).
C1 [Watterberg, Kristi L.; Lowe, Jean; Lacy, Conra Backstrom; Ohls, Robin K.; Fuller, Jane; Thomson, Rebecca A.] Univ New Mexico, Hlth Sci Ctr, Albuquerque, NM 87131 USA.
   [Hintz, Susan R.] Stanford Univ, Dept Pediat, Div Neonatal & Dev Med, Palo Alto, CA 94304 USA.
   [Hintz, Susan R.; Van Meurs, Krisa P.; Stevenson, David K.; Ball, M. Bethany; DeAnda, Maria Elena; Goodlin, Gabrielle T.] Lucile Packard Childrens Hosp, Palo Alto, CA USA.
   [Do, Barbara; Newman, Jamie E.; Wallace, Dennis] RTI Int, Social Stat & Environm Sci Unit, Res Triangle Pk, NC USA.
   [Vohr, Betty R.] Brown Univ, Women & Infants Hosp, Dept Pediat, Providence, RI 02908 USA.
   [Davis, Elysia Poggi] Univ Denver, Dept Psychol, Denver, CO 80208 USA.
   [Granger, Douglas A.] Univ Calif Irvine, Inst Interdisciplinary Salivary Biosci Res, Irvine, CA USA.
   [Shankaran, Seetha] Wayne State Univ, Dept Pediat, Detroit, MI 48202 USA.
   [Payne, Allison] Case Western Reserve Univ, Rainbow Babies & Childrens Hosp, Dept Pediat, Cleveland, OH 44106 USA.
   [Higgins, Rosemary D.] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, NIH, Bethesda, MD USA.
   [Jobe, Alan H.] Univ Cincinnati, Cincinnati, OH 45221 USA.
   [Caplan, Michael S.] Univ Chicago, Pritzker Sch Med, Chicago, IL 60637 USA.
   [Polin, Richard A.] Columbia Univ, Coll Phys & Surg, Div Neonatol, New York, NY 10027 USA.
   [Laptook, Abbot R.; Hensman, Angelita M.; Vieira, Elisa; Little, Emilee; Johnson, Katharine; Alksninis, Barbara; Keszler, Mary Lenore; Knoll, Andrea M.; Leach, Theresa M.; McGowan, Elisabeth C.; Watson, Victoria E.] Brown Univ, Alpert Med Sch, Providence, RI 02912 USA.
   [Laptook, Abbot R.; Hensman, Angelita M.; Vieira, Elisa; Little, Emilee; Johnson, Katharine; Alksninis, Barbara; Keszler, Mary Lenore; Knoll, Andrea M.; Leach, Theresa M.; McGowan, Elisabeth C.; Watson, Victoria E.] Women & Infants Hosp Rhode Isl, Providence, RI 02908 USA.
   [Walsh, Michele C.; Fanaroff, Avroy A.; Wilson-Costello, Deanne E.; Newman, Nancy S.; Siner, Bonnie S.; Zadell, Arlene; DiFiore, Julie; Bhola, Monika; Friedman, Harriet G.; Yalcinkaya, Gulgun] Case Western Reserve Univ, Rainbow Babies & Childrens Hosp, Cleveland, OH 44106 USA.
   [Goldberg, Ronald N.; Cotten, C. Michael; Gustafson, Kathryn E.; Goldstein, Ricki F.; Ashley, Patricia; Auten, Kathy J.; Fisher, Kimberley A.; Foy, Katherine A.; Freedman, Sharon F.; Lohmeyer, Melody B.; Malcolm, William F.] Duke Univ, Sch Med, Univ Hosp, Durham, NC 27706 USA.
   [Goldberg, Ronald N.; Cotten, C. Michael; Gustafson, Kathryn E.; Goldstein, Ricki F.; Ashley, Patricia; Auten, Kathy J.; Fisher, Kimberley A.; Foy, Katherine A.; Freedman, Sharon F.; Lohmeyer, Melody B.; Malcolm, William F.] Duke Reg Hosp, Durham, NC USA.
   [Wallace, David K.; Carlton, David P.; Stoll, Barbara J.; Adams-Chapman, Ira; Buchter, Susie; Piazza, Anthony J.; Carter, Sheena; Fritz, Sobha; Hale, Ellen C.; Hutchinson, Amy K.; LaRossa, Maureen Mulligan; Loggins, Yvonne; Bottcher, Diane] Emory Univ, Grady Mem Hosp, Childrens Healthcare Atlanta, Atlanta, GA 30322 USA.
   [Wallace, David K.; Carlton, David P.; Stoll, Barbara J.; Adams-Chapman, Ira; Buchter, Susie; Piazza, Anthony J.; Carter, Sheena; Fritz, Sobha; Hale, Ellen C.; Hutchinson, Amy K.; LaRossa, Maureen Mulligan; Loggins, Yvonne; Bottcher, Diane] Emory Crawford Long Hosp, Atlanta, GA USA.
   [Archer, Stephanie Wilson] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Bethesda, MD USA.
   [Poindexter, Brenda B.; Sokol, Gregory M.; Harmon, Heidi M.; Papile, Lu-Ann; Hines, Abbey C.; Wilson, Leslie D.; Herron, Dianne E.; Smiley, Lucy] Indiana Univ, Univ Hosp, Methodist Hosp, Riley Hosp Children, Bloomington, IN 47405 USA.
   [Poindexter, Brenda B.; Sokol, Gregory M.; Harmon, Heidi M.; Papile, Lu-Ann; Hines, Abbey C.; Wilson, Leslie D.; Herron, Dianne E.; Smiley, Lucy] Wishard Hlth Serv, Indianapolis, IN USA.
   [Kennedy, Kathleen A.; Tyson, Jon E.; Duncan, Andrea F.; Dempsey, Allison G.; John, Janice; Jones, Patrick M.; Lillie, M. Layne; Siddiki, Saba; Sperry, Daniel K.] Univ Texas Hlth Sci Ctr Houston, McGovern Med Sch, Houston, TX 77030 USA.
   [Kennedy, Kathleen A.; Tyson, Jon E.; Duncan, Andrea F.; Dempsey, Allison G.; John, Janice; Jones, Patrick M.; Lillie, M. Layne; Siddiki, Saba; Sperry, Daniel K.] Childrens Mem Hermann Hosp, Houston, TX USA.
   [Blaisdell, Carol J.; Pemberton, Victoria] NHLBI, Bldg 10, Bethesda, MD 20892 USA.
   [Wallace, Dennis; Das, Abhik; Gantz, Marie G.; Auman, Jeanette O'Donnell; Hammond, Jane A.; Poole, W. Kenneth] RTI Int, Res Triangle Pk, NC USA.
   [Van Meurs, Krisa P.; Stevenson, David K.; Ball, M. Bethany; DeAnda, Maria Elena; Goodlin, Gabrielle T.] Stanford Univ, Stanford, CA 94305 USA.
   [McGowan, Elisabeth C.; Frantz, Ivan D., III; Fiascone, John M.; Kurfiss, Anne; MacKinnon, Brenda L.; Nylen, Ellen; Brussa, Ana; Sibley, Cecelia] Floating Hosp Children, Tufts Med Ctr, Boston, MA USA.
   [Carlo, Waldemar A.; Ambalavanan, Namasivayam; Collins, Monica, V; Cosby, Shirley S.; Phillips, Vivien A.; Domanovich, Kristy; Whitley, Sally; Smith, Leigh Ann; Kiser, Carin R.] Univ Alabama Birmingham Hlth Syst, Birmingham, AL USA.
   [Carlo, Waldemar A.; Ambalavanan, Namasivayam; Collins, Monica, V; Cosby, Shirley S.; Phillips, Vivien A.; Domanovich, Kristy; Whitley, Sally; Smith, Leigh Ann; Kiser, Carin R.] Childrens Hosp Alabama, Birmingham, AL USA.
   [Finer, Neil N.; Garey, Donna; Rasmussen, Maynard R.; Wozniak, Paul R.; Vaucher, Yvonne E.; Fuller, Martha G.; Akshoomoff, Natacha; Rich, Wade; Arnell, Kathy; Bridge, Renee] Univ Calif San Diego, Med Ctr, La Jolla, CA 92093 USA.
   [Finer, Neil N.; Garey, Donna; Rasmussen, Maynard R.; Wozniak, Paul R.; Vaucher, Yvonne E.; Fuller, Martha G.; Akshoomoff, Natacha; Rich, Wade; Arnell, Kathy; Bridge, Renee] Sharp Mary Birch Hosp Women, San Diego, CA USA.
   [Bell, Edward F.; Colaizy, Tarah T.; Widness, John A.; Klein, Jonathan M.; Johnson, Karen J.; Acarregui, Michael J.; Eastman, Diane L.; Wilgenbusch, Tammy L., V] Univ Iowa, Iowa City, IA 52242 USA.
   [Brown, Sandra; Sanchez, Pablo J.; Heyne, Roy J.; Rosenfeld, Charles R.; Salhab, Walid A.; Brion, Luc; Adams, Sally S.; Allen, James; Grau, Laura; Guzman, Alicia; Hensley, Gaynelle; Heyne, Elizabeth T.; Hickman, Jackie F.; Lee, Lizette E.; Leps, Melissa H.; Madden, Linda A.; Martin, Melissa Swensen; Miller, Nancy A.; Morgan, Janet S.; Solis, Araceli; Boatman, Catherine Twell; Vasil, Diana M.] Univ Texas Southwestern Med Ctr Dallas, Parkland Hlth & Hosp Syst, Dallas, TX 75390 USA.
   [Brown, Sandra; Sanchez, Pablo J.; Heyne, Roy J.; Rosenfeld, Charles R.; Salhab, Walid A.; Brion, Luc; Adams, Sally S.; Allen, James; Grau, Laura; Guzman, Alicia; Hensley, Gaynelle; Heyne, Elizabeth T.; Hickman, Jackie F.; Lee, Lizette E.; Leps, Melissa H.; Madden, Linda A.; Martin, Melissa Swensen; Miller, Nancy A.; Morgan, Janet S.; Solis, Araceli; Boatman, Catherine Twell; Vasil, Diana M.] Childrens Med Ctr Dallas, Dallas, TX USA.
   [Yoder, Bradley A.; Faix, Roger G.; Baker, Shawna; Osborne, Karen A.; Rau, Carrie A.; Winter, Sarah; Cunningham, Sean D.; Ford, Ariel C.] Univ Utah, Med Ctr, Intermt Med Ctr, LDS Hosp, Salt Lake City, UT 84112 USA.
   [Yoder, Bradley A.; Faix, Roger G.; Baker, Shawna; Osborne, Karen A.; Rau, Carrie A.; Winter, Sarah; Cunningham, Sean D.; Ford, Ariel C.] Primary Childrens Med Ctr, Salt Lake City, UT 84103 USA.
   [Pappas, Athina; Sood, Beena G.; Bara, Rebecca; Slovis, Thomas L.; Goldston, Laura A.; Johnson, Mary] Wayne State Univ, Hutzel Womens Hosp, Detroit, MI 48202 USA.
   [Pappas, Athina; Sood, Beena G.; Bara, Rebecca; Slovis, Thomas L.; Goldston, Laura A.; Johnson, Mary] Childrens Hosp Michigan, Detroit, MI 48201 USA.
C3 University of New Mexico; University of New Mexico's Health Sciences
   Center; Stanford University; Lucile Packard Children's Hospital (LPCH);
   Research Triangle Institute; Women & Infants Hospital Rhode Island;
   Brown University; University of Denver; University of California System;
   University of California Irvine; Wayne State University; University
   Hospitals of Cleveland; Rainbow Babies & Children's Hospital; University
   System of Ohio; Case Western Reserve University; Case Western Reserve
   University Hospital; National Institutes of Health (NIH) - USA; NIH
   Eunice Kennedy Shriver National Institute of Child Health & Human
   Development (NICHD); University System of Ohio; University of
   Cincinnati; University of Chicago; Columbia University; Brown
   University; Women & Infants Hospital Rhode Island; University Hospitals
   of Cleveland; Rainbow Babies & Children's Hospital; University System of
   Ohio; Case Western Reserve University; Case Western Reserve University
   Hospital; Duke University; Emory University; Children's Healthcare of
   Atlanta (CHOA); National Institutes of Health (NIH) - USA; NIH Eunice
   Kennedy Shriver National Institute of Child Health & Human Development
   (NICHD); Indiana University System; Indiana University Bloomington;
   Indiana University Health; James Whitcomb Riley Hospital Children;
   University of Texas System; University of Texas Health Science Center
   Houston; National Institutes of Health (NIH) - USA; NIH National Heart
   Lung & Blood Institute (NHLBI); Research Triangle Institute; Stanford
   University; Tufts Medical Center; Floating Hospital For Children;
   University of California System; University of California San Diego;
   University of Iowa; University of Texas System; University of Texas
   Southwestern Medical Center Dallas; Utah System of Higher Education;
   University of Utah; Intermountain Healthcare; Intermountain Medical
   Center; Wayne State University; Children's Hospital of Michigan
RP Watterberg, KL (corresponding author), Univ New Mexico, Hlth Sci Ctr, Albuquerque, NM 87131 USA.
EM Kwatterberg@salud.unm.edu
RI Ambalavanan, Namasivayam/AAL-3832-2020; Wallace, Dennis/AAR-7005-2021;
   Brion, Luc/ABB-5529-2022; Stoll, Barbara/JRZ-1165-2023; Davis,
   Elysia/B-7621-2013; Osborn, Karen/JCP-4942-2023; Hardt,
   Elisa/F-8935-2018; Wallace, David/KWU-9111-2024; Das,
   Abhik/AAF-1883-2020
OI Hintz, Susan/0000-0001-7023-4433; Payne, Allison/0000-0003-0216-6269;
   Das, Abhik/0000-0003-2722-0479; Davis, Elysia/0000-0001-6345-9271; Do,
   Barbara T./0000-0002-6012-1168; Newman, Jamie/0000-0001-8880-8132
FU National Institutes of Health, the Eunice Kennedy Shriver National
   Institute of Child Health and Human Development (NICHD); National Heart,
   Lung, and Blood Institute (NHLBI); NHLBI [R01HL117764]
FX The National Institutes of Health, the Eunice Kennedy Shriver National
   Institute of Child Health and Human Development (NICHD), and the
   National Heart, Lung, and Blood Institute (NHLBI) provided grant support
   for the Neonatal Research Network's Extended Follow-up at School Age for
   the SUPPORT Neuroimaging and Neurodevelopmental Outcomes (NEURO) Cohort
   through cooperative agreements. NHLBI provided support for this study
   (R01HL117764). While NICHD staff had input into the study design,
   conduct, analysis, and manuscript drafting, the comments and views of
   the authors do not necessarily represent the views of the NICHD. Data
   collected at participating sites of the NICHD Neonatal Research Network
   (NRN) were transmitted to RTI International, the data coordinating
   center (DCC) for the network, which stored, managed and analyzed the
   data for this study. On behalf of the NRN, Drs. Abhik Das (DCC Principal
   Investigator), Marie Gantz, Lisa Wrage, and Helen Cheng (DCC
   Statisticians) had full access to all the data in the study and take
   responsibility for the integrity of the data and accuracy of the data
   analysis. We are indebted to our medical and nursing colleagues and the
   infants and their parents who agreed to take part in this study.
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NR 41
TC 17
Z9 18
U1 0
U2 1
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0031-3998
EI 1530-0447
J9 PEDIATR RES
JI Pediatr. Res.
PD SEP
PY 2019
VL 86
IS 3
BP 339
EP 347
DI 10.1038/s41390-018-0243-1
PG 9
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA IR7VB
UT WOS:000481648100011
PM 30631138
OA Green Submitted, Bronze, Green Accepted
DA 2025-06-11
ER

PT J
AU García-Arroyo, FE
   Tapia, E
   Blas-Marron, MG
   Gonzaga, G
   Silverio, O
   Cristóbal, M
   Osorio, H
   Arellano-Buendía, AS
   Zazueta, C
   Aparicio-Trejo, OE
   Reyes-García, JG
   Pedraza-Chaverri, J
   Soto, V
   Roncal-Jiménez, C
   Johnson, RJ
   Sánchez-Lozada, LG
AF Garcia-Arroyo, Fernando E.
   Tapia, Edilia
   Blas-Marron, Monica G.
   Gonzaga, Guillermo
   Silverio, Octaviano
   Cristobal, Magdalena
   Osorio, Horacio
   Arellano-Buendia, Abraham S.
   Zazueta, Cecilia
   Emiliano Aparicio-Trejo, Omar
   Reyes-Garcia, Juan G.
   Pedraza-Chaverri, Jose
   Soto, Virgilia
   Roncal-Jimenez, Carlos
   Johnson, Richard J.
   Sanchez-Lozada, Laura G.
TI Vasopressin Mediates the Renal Damage Induced by Limited Fructose
   Rehydration in Recurrently Dehydrated Rats
SO INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
LA English
DT Article
DE Vasopressin; chronic kidney disease
ID MITOCHONDRIAL OXIDATIVE STRESS; INDUCED METABOLIC SYNDROME; HEAT-STRESS;
   SKELETAL-MUSCLE; MESOAMERICAN NEPHROPATHY; GLOMERULAR HYPERTENSION;
   URIC-ACID; INJURY; WATER; KIDNEY
AB Recurrent dehydration and heat stress cause chronic kidney damage in experimental animals. The injury is exacerbated by rehydration with fructose-containing beverages. Fructose may amplify dehydration-induced injury by directly stimulating vasopressin release and also by acting as a substrate for the aldose reductase-fructokinase pathway, as both of these systems are active during dehydration. The role of vasopressin in heat stress associated injury has not to date been explored. Here we show that the amplification of renal damage mediated by fructose in thermal dehydration is mediated by vasopressin. Fructose rehydration markedly enhanced vasopressin (copeptin) levels and activation of the aldose reductase-fructokinase pathway in the kidney. Moreover, the amplification of the renal functional changes (decreased creatinine clearance and tubular injury with systemic inflammation, renal oxidative stress, and mitochondrial dysfunction) were prevented by the blockade of V1a and V2 vasopressin receptors with conivaptan. On the other hand, there are also other operative mechanisms when water is used as rehydration fluid that produce milder renal damage that is not fully corrected by vasopressin blockade. Therefore, we clearly showed evidence of the cross-talk between fructose, even at small doses, and vasopressin that interact to amplify the renal damage induced by dehydration. These data may be relevant for heat stress nephropathy as well as for other renal pathologies due to the current generalized consumption of fructose and deficient hydration habits.
C1 [Garcia-Arroyo, Fernando E.; Tapia, Edilia; Blas-Marron, Monica G.; Gonzaga, Guillermo; Silverio, Octaviano; Cristobal, Magdalena; Osorio, Horacio; Arellano-Buendia, Abraham S.; Sanchez-Lozada, Laura G.] INC Ignacio Chavez, Lab Renal Physiopathol, Mexico City, DF, Mexico.
   [Tapia, Edilia; Cristobal, Magdalena; Osorio, Horacio; Arellano-Buendia, Abraham S.; Sanchez-Lozada, Laura G.] INC Ignacio Chavez, Dept Nephrol, Mexico City, DF, Mexico.
   [Zazueta, Cecilia] INC Ignacio Chavez, Dept Cardiovasc Biomed, Mexico City, DF, Mexico.
   [Emiliano Aparicio-Trejo, Omar; Pedraza-Chaverri, Jose] Univ Nacl Autonoma Mexico, Fac Chem, Dept Biol, Mexico City, DF, Mexico.
   [Reyes-Garcia, Juan G.] IPN Mexico City, Escuela Super Med, Secc Estudios Posgrad & Invest, Mexico City, DF, Mexico.
   [Soto, Virgilia] INC Ignacio Chavez, Dept Pathol, Mexico City, DF, Mexico.
   [Roncal-Jimenez, Carlos; Johnson, Richard J.] Univ Colorado, Div Renal Dis, Aurora, CO USA.
C3 Universidad Nacional Autonoma de Mexico; University of Colorado System;
   University of Colorado Anschutz Medical Campus
RP Sánchez-Lozada, LG (corresponding author), INC Ignacio Chavez, Lab Renal Physiopathol, Mexico City, DF, Mexico.; Sánchez-Lozada, LG (corresponding author), INC Ignacio Chavez, Dept Nephrol, Mexico City, DF, Mexico.
RI Aparicio-Trejo, Omar/AAQ-3900-2021; Zazueta, Cecilia/AAM-7502-2021;
   Sanchez-Lozada, Laura/AAS-2104-2021; Alonso, Horacio/T-3946-2019
OI Reyes-Garcia, Juan Gerardo/0000-0002-7524-9375; Aparicio-Trejo, Omar
   Emiliano/0000-0002-7701-4537; Osorio Alonso,
   Horacio/0000-0002-9238-4202; Sanchez-Lozada,
   Laura-Gabriela/0000-0003-0348-9617; Garcia Arroyo, Fernando
   Enrique/0000-0003-1545-9765; Tapia, Edilia/0000-0001-7955-816X
FU Danone Research, Palaiseau, France
FX This study was supported by generous funds from Danone Research,
   Palaiseau, France.
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NR 52
TC 53
Z9 59
U1 0
U2 5
PU IVYSPRING INT PUBL
PI LAKE HAVEN
PA PO BOX 4546, LAKE HAVEN, NSW 2263, AUSTRALIA
SN 1449-2288
J9 INT J BIOL SCI
JI Int. J. Biol. Sci.
PY 2017
VL 13
IS 8
BP 961
EP 975
DI 10.7150/ijbs.20074
PG 15
WC Biochemistry & Molecular Biology; Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics
GA FE7FK
UT WOS:000408372800002
PM 28924378
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Tatsch, E
   De Carvalho, JAM
   Bollick, YS
   Duarte, T
   Duarte, MMMF
   Vaucher, RA
   Premaor, MO
   Comim, FV
   Moresco, RN
AF Tatsch, Etiane
   De Carvalho, Jose A. M.
   Bollick, Yanai S.
   Duarte, Thiago
   Duarte, Marta M. M. F.
   Vaucher, Rodrigo A.
   Premaor, Melissa O.
   Comim, Fabio, V
   Moresco, Rafael N.
TI Low frataxin mRNA expression is associated with inflammation and
   oxidative stress in patients with type 2 diabetes
SO DIABETES-METABOLISM RESEARCH AND REVIEWS
LA English
DT Article
DE frataxin; inflammation; iron; mitochondria; oxidative stress; type 2
   diabetes
ID BETA-CELL FUNCTION; INSULIN-RESISTANCE; METABOLIC SYNDROME; FRIEDREICH
   ATAXIA; IRON; MITOCHONDRIAL; GENE; GLUCOSE; PROTEIN; MECHANISMS
AB Background The mitochondrial protein frataxin is involved in iron metabolism, as well as regulation of oxidative stress. To elucidate the association of frataxin with the pathophysiology of diabetes, we evaluated the mRNA levels of frataxin in leukocytes of patients with type 2 diabetes (T2D). In addition, we investigated the relation between frataxin mRNA levels, inflammatory cytokines, and oxidative stress biomarkers. Methods A study including 150 subjects (115 patients with T2D and 35 healthy subjects) was performed to evaluate the frataxin mRNA levels in leukocytes. We assessed the relation between frataxin and interleukin (IL)-6, IL-1, tumour necrosis factor-alpha (TNF-alpha), total oxidation status (TOS), total antioxidant capacity (TAC), and serum iron. Results The frataxin mRNA levels in the T2D group were significantly lower than those in healthy subjects. It was also demonstrated that T2D patients with frataxin mRNA levels in the lowest quartile had significantly elevated levels of serum iron, TOS, and inflammatory cytokines, such as TNF-alpha, IL-1, and IL-6, while TAC levels were significantly lower in this quartile when compared with the upper quartile. Conclusions Our findings showed that T2D patients with low frataxin mRNA levels showed a high degree of inflammation and oxidative stress. It is speculated that frataxin deficiency in T2D patients can contribute to the imbalance in mitochondrial iron homeostasis leading to the acceleration of oxidative stress and inflammation.
C1 [Tatsch, Etiane; De Carvalho, Jose A. M.; Bollick, Yanai S.; Moresco, Rafael N.] Univ Fed Santa Maria, Dept Clin & Toxicol Anal, Lab Clin Biochem, Santa Maria, RS, Brazil.
   [De Carvalho, Jose A. M.] Univ Hosp, Lab Clin Anal, Santa Maria, RS, Brazil.
   [Duarte, Thiago] Univ Fed Santa Maria, Lab Biogen, Santa Maria, RS, Brazil.
   [Duarte, Marta M. M. F.] Univ Luterana Brasil, Dept Hlth Sci, Santa Maria, RS, Brazil.
   [Vaucher, Rodrigo A.] Univ Fed Pelotas, Ctr Chem Pharmaceut & Food Sci, Pelotas, RS, Brazil.
   [Premaor, Melissa O.; Comim, Fabio, V] Univ Fed Santa Maria, Dept Clin Med, Santa Maria, RS, Brazil.
C3 Universidade Federal de Santa Maria (UFSM); Universidade Federal de
   Santa Maria (UFSM); Universidade Luterana do Brasil; Universidade
   Federal de Pelotas; Universidade Federal de Santa Maria (UFSM)
RP Moresco, RN (corresponding author), Univ Fed Santa Maria, Ctr Ciencias Saude, Dept Anal Clin & Toxicol, Ave Roraima 1000,Predio 26,Sala 1401, BR-97105900 Santa Maria, RS, Brazil.
EM mmoresco@ufsm.br
RI de Almeida Vaucher, Rodrigo/A-3906-2016; de Carvalho, José/F-9418-2015;
   Premaor, Melissa/K-7401-2016; Comim, Fabio/L-1298-2015; Moresco,
   Rafael/K-6118-2017
OI VAUCHER, RODRIGO/0000-0002-8306-9243; Moresco,
   Rafael/0000-0003-3072-5080; Vasconcellos Comim,
   Fabio/0000-0002-2726-233X
FU Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior [001];
   Conselho Nacional de Desenvolvimento Cientifico e Tecnologico
   [309799/2017-1, 428321/2016-0]
FX Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior, Grant/Award
   Number: Finance code 001; Conselho Nacional de Desenvolvimento
   Cientifico e Tecnologico, Grant/Award Numbers: 309799/2017-1 and
   428321/2016-0
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NR 57
TC 3
Z9 3
U1 0
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1520-7552
EI 1520-7560
J9 DIABETES-METAB RES
JI Diabetes-Metab. Res. Rev.
PD JAN
PY 2020
VL 36
IS 1
AR e3208
DI 10.1002/dmrr.3208
EA AUG 2019
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA KB2XA
UT WOS:000487421800001
PM 31343823
OA Bronze
DA 2025-06-11
ER

PT J
AU Zhang, X
   Yang, L
   Xu, XF
   Tang, FJ
   Yi, P
   Qiu, B
   Hao, YR
AF Zhang, Xiang
   Yang, Luo
   Xu, Xiongfeng
   Tang, Fengjuan
   Yi, Peng
   Qiu, Bo
   Hao, Yarong
TI A review of fibroblast growth factor 21 in diabetic cardiomyopathy
SO HEART FAILURE REVIEWS
LA English
DT Review
DE FGF21 (fibroblast growth factor 21); Diabetic cardiomyopathy; Oxidative
   stress; Myocardial cell energy metabolism; Collagen deposition;
   Inflammatory response; Apoptosis
ID ENDOPLASMIC-RETICULUM STRESS; NF-KAPPA-B; INDUCED OXIDATIVE STRESS;
   PROTEIN-KINASE-C; BETA-KLOTHO; DIASTOLIC DYSFUNCTION; CARDIAC
   DYSFUNCTION; THERAPEUTIC TARGET; FACTOR FAMILY; BODY-WEIGHT
AB FGF21 (fibroblast growth factor 21) is a regulator of metabolism and performs an important role in glucose and lipid metabolism and the maintenance of energy balance. FGF21 is principally expressed in the liver, but it can also be found in the pancreas, skeletal muscle, and adipose tissue. It is known that levels of serum FGF21 are significantly elevated in obese, insulin-resistant patients, and those with metabolic syndrome. Elevated levels of FGF21 in serum during the early stages of various metabolic diseases are considered a compensatory response by the organism. Therefore, FGF21 is considered a hormone in response to stress and an early diagnostic marker of disease. Diabetic cardiomyopathy is a special type of cardiac complication, characterized as a chronic myocardial disorder caused by diabetes. The pathological process includes increased oxidative stress, energy metabolism in myocardial cells, an inflammatory response, and myocardial cell apoptosis. A growing body of evidence suggests that FGF21 has the potential to be an effective drug for the treatment of diabetic cardiomyopathy. Here, we review recent progress on the characteristics of FGF21 in its protective role, especially in pathological processes such as suppressing apoptosis in the myocardium, reducing inflammation in cardiomyocytes, reducing oxidative stress, and promoting fatty acid oxidation. In addition, we explore the possibility that diabetic cardiomyopathy can be delayed through the application of FGF21, providing possible therapeutic targets of the disease.
C1 [Zhang, Xiang; Yang, Luo; Xu, Xiongfeng; Tang, Fengjuan; Yi, Peng; Qiu, Bo; Hao, Yarong] Wuhan Univ, Renming Hosp, Dept Geriatr, Wuhan, Hubei, Peoples R China.
   [Zhang, Xiang; Yang, Luo; Xu, Xiongfeng; Tang, Fengjuan; Yi, Peng; Qiu, Bo; Hao, Yarong] Wuhan Univ, Renming Hosp, Cent Lab, Wuhan, Hubei, Peoples R China.
   [Hao, Yarong] Wuhan Univ, Renming Hosp, Dept Geriatr, Div Metab Syndrome, 99 Zhang Zhidong Rd, Wuhan 430060, Hubei, Peoples R China.
C3 Wuhan University; Wuhan University; Wuhan University
RP Hao, YR (corresponding author), Wuhan Univ, Renming Hosp, Dept Geriatr, Wuhan, Hubei, Peoples R China.; Hao, YR (corresponding author), Wuhan Univ, Renming Hosp, Cent Lab, Wuhan, Hubei, Peoples R China.; Hao, YR (corresponding author), Wuhan Univ, Renming Hosp, Dept Geriatr, Div Metab Syndrome, 99 Zhang Zhidong Rd, Wuhan 430060, Hubei, Peoples R China.
EM 464339603@qq.com; 1220692446@qq.com; 1184446045@qq.com;
   1242965591@qq.com; 747432702@qq.com; 1657750128@qq.com; 984022801@qq.com
RI Zhang, Xiangyu/ABC-2896-2021
FU Hubei Natural Science Foundation of China [2016CFB673]
FX The authors received writing/editorial support in the preparation of
   this manuscript provided by Dr. Hao Yarong (Wuhan University), funded by
   the Hubei Natural Science Foundation of China (number 2016CFB673).
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NR 119
TC 33
Z9 34
U1 5
U2 30
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1382-4147
EI 1573-7322
J9 HEART FAIL REV
JI Heart Fail. Rev.
PD NOV
PY 2019
VL 24
IS 6
BP 1005
EP 1017
DI 10.1007/s10741-019-09809-x
PG 13
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA JK6EK
UT WOS:000494934200013
PM 31175491
DA 2025-06-11
ER

PT J
AU Milian, J
   Goldfine, AB
   Zuflacht, JP
   Parmer, C
   Beckman, JA
AF Milian, Jessica
   Goldfine, Allison B.
   Zuflacht, Jonah P.
   Parmer, Caitlin
   Beckman, Joshua A.
TI Atazanavir improves cardiometabolic measures but not vascular function
   in patients with long-standing type 1 diabetes mellitus
SO ACTA DIABETOLOGICA
LA English
DT Article
DE Type 1 diabetes; Endothelium; Oxidative stress; Bilirubin
ID ENDOTHELIUM-DEPENDENT VASODILATION; NITRIC-OXIDE SYNTHASE; TOTAL
   BILIRUBIN LEVEL; OXIDATIVE STRESS; CARDIOVASCULAR EVENTS; DISEASE
   PATHOPHYSIOLOGY; CLINICAL CONSEQUENCES; MYOCARDIAL-INFARCTION;
   SUPEROXIDE-PRODUCTION; GILBERT-SYNDROME
AB Vascular disease is the leading cause of morbidity and mortality in type 1 diabetes mellitus (T1DM). We previously demonstrated that patients with T1DM have impaired endothelial function, a forme fruste of atherosclerosis, as a result of increased oxidative stress. Bilirubin has emerged as a potent endogenous antioxidant with higher concentrations associated with lower rates of myocardial infarction and stroke.
   We tested the hypothesis that increasing endogenous bilirubin using atazanavir would improve cardiometabolic risk factors and vascular function in patients with T1DM to determine whether targeting bilirubin may be a novel therapeutic approach to reduce cardiovascular disease risk in this population. In this single-arm, open-label study, we evaluated blood pressure, lipid profile, and conduit artery function in fifteen subjects (mean age 45 +/- A 9 years) with T1DM following a 4-day treatment with atazanavir.
   As anticipated, atazanavir significantly increased both serum total bilirubin levels (p < 0.0001) and plasma total antioxidant capacity (p < 0.0001). Reductions in total cholesterol (p = 0.04), LDL cholesterol (p = 0.04), and mean arterial pressure (p = 0.04) were also observed following atazanavir treatment. No changes were seen in either flow-mediated endothelium-dependent (p = 0.92) or nitroglycerine-mediated endothelium-independent (p = 0.68) vasodilation, measured by high-resolution B-mode ultrasonography at baseline and post-treatment.
   Increasing serum bilirubin levels with atazanavir in subjects with T1DM over 4 days favorably reduces LDL and blood pressure but is not associated with improvements in endothelial function of conduit arteries.
C1 [Milian, Jessica; Zuflacht, Jonah P.; Parmer, Caitlin; Beckman, Joshua A.] Brigham & Womens Hosp, Cardiovasc Div, Boston, MA 02115 USA.
   [Goldfine, Allison B.] Joslin Diabet Ctr, Clin Res, Boston, MA 02215 USA.
C3 Harvard University; Harvard University Medical Affiliates; Brigham &
   Women's Hospital; Harvard University; Harvard University Medical
   Affiliates; Joslin Diabetes Center, Inc.
RP Beckman, JA (corresponding author), Brigham & Womens Hosp, Cardiovasc Div, 75 Francis St, Boston, MA 02115 USA.
EM jbeckman@partners.org
RI Beckman, Joshua/A-7537-2016
OI Beckman, Joshua/0000-0001-8332-8439; Keilson,
   Jessica/0000-0002-8695-431X; Parmer, Caitlin/0000-0003-0770-2286
FU National Institutes of Health, National Institute of Diabetes, Digestive
   and Kidney Disease [1R03 DK094510-01]; NIDDK Diabetes Research Center
   [P30DK036836]
FX Dr. Beckman is supported by National Institutes of Health, National
   Institute of Diabetes, Digestive and Kidney Disease Grant 1R03
   DK094510-01. Dr. Goldfine is supported by NIDDK Diabetes Research Center
   Grant P30DK036836. The content of this manuscript is solely the
   responsibility of the authors and does not necessarily represent the
   official views of the funding agencies.
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NR 54
TC 7
Z9 8
U1 0
U2 2
PU SPRINGER-VERLAG ITALIA SRL
PI MILAN
PA VIA DECEMBRIO, 28, MILAN, 20137, ITALY
SN 0940-5429
EI 1432-5233
J9 ACTA DIABETOL
JI Acta Diabetol.
PD AUG
PY 2015
VL 52
IS 4
BP 709
EP 715
DI 10.1007/s00592-014-0708-6
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA CN0EE
UT WOS:000358085800009
PM 25563478
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Kumari, S
   Barton, GP
   Goss, KN
AF Kumari, Santosh
   Barton, Gregory P.
   Goss, Kara N.
TI Increased mitochondrial oxygen consumption in adult survivors of preterm
   birth
SO PEDIATRIC RESEARCH
LA English
DT Article
AB Background Premature birth affects roughly 10% of live births and is associated with long-term increased risk for multiple comorbidities. Although many comorbidities are associated with increased oxidative stress, the potential late impact of extreme premature birth on mitochondrial function has not previously been assessed. We hypothesized that mitochondrial function would be impaired in adult survivors of premature birth. Methods Mitochondrial function in peripheral blood mononuclear cells from young adults born moderately to extremely preterm was measured using a Seahorse XF Analyzer at baseline and in response to acute oxidative stress, and compared to age-matched term-born adults. Adult pulmonary function was also obtained. Results Young adults born preterm (average gestational age 29 weeks) had increased mitochondrial oxygen consumption at baseline, particularly with respect to basal and non-ATP-linked respiration. Maximal and spare capacities were also higher, even in response to acute oxidative stress. Lung function was lower in adults born preterm, and the degree of airflow obstruction correlated only modestly with mitochondrial function. Conclusions In conclusion, adults born preterm have higher basal and non-ATP-linked mitochondrial respiration. Similar mitochondrial profiles have previously been documented in diabetics, and may support the increased risk for cardiometabolic disease in adults born preterm. Impact
   Adults born preterm have higher maximal but also higher basal and non-ATP-linked mitochondrial respiration. Similar mitochondrial profiles have previously been documented in diabetics, and may support the increased risk for cardiometabolic disease in adults born preterm. Prior studies demonstrate a link between perinatal mitochondrial function and risk for development of bronchopulmonary dysplasia. Here, maximal mitochondrial respiration correlates modestly with adult lung function. Peripheral blood mononuclear cell mitochondrial function may be a biomarker of both early lung function and late cardiometabolic risk after preterm birth.
C1 [Kumari, Santosh; Goss, Kara N.] Univ Wisconsin, Dept Med, Sch Med & Publ Hlth, Madison, WI 53706 USA.
   [Barton, Gregory P.; Goss, Kara N.] Univ Wisconsin, Dept Pediat, Sch Med & Publ Hlth, Madison, WI 53706 USA.
C3 University of Wisconsin System; University of Wisconsin Madison;
   University of Wisconsin System; University of Wisconsin Madison
RP Goss, KN (corresponding author), Univ Wisconsin, Dept Med, Sch Med & Publ Hlth, Madison, WI 53706 USA.; Goss, KN (corresponding author), Univ Wisconsin, Dept Pediat, Sch Med & Publ Hlth, Madison, WI 53706 USA.
EM Kara.Goss@UTSouthwestern.edu
RI Barton, Greg/AAS-7503-2021
OI Barton, Gregory/0000-0001-7471-5488
FU National Institute of Allergy and Immunological Diseases [T32AI007635];
   University of Wisconsin Clinical and Translational Science Award (CTSA)
   program, through the NIH National Center for Advancing Translational
   Sciences (NCATS) [NIH UL1TR000427, 4KL2TR000428-10]; Parker B. Francis
   Fellowship; American Heart Association Career Development Award
   [18CDA34110440]; American Heart Association (AHA) [18CDA34110440]
   Funding Source: American Heart Association (AHA)
FX We thank Dr. Joshua Fessel for critical discussion and insight. G.P.B.
   was supported by the National Institute of Allergy and Immunological
   Diseases (T32AI007635); K.N.G. was supported by the University of
   Wisconsin Clinical and Translational Science Award (CTSA) program,
   through the NIH National Center for Advancing Translational Sciences
   (NCATS), Grant NIH UL1TR000427 (Primary investigator Marc Drezner;
   4KL2TR000428-10), as well as a Parker B. Francis Fellowship Award and
   American Heart Association Career Development Award (Goss,
   #18CDA34110440).
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NR 29
TC 14
Z9 15
U1 0
U2 1
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0031-3998
EI 1530-0447
J9 PEDIATR RES
JI Pediatr. Res.
PD DEC
PY 2021
VL 90
IS 6
BP 1147
EP 1152
DI 10.1038/s41390-021-01387-9
EA FEB 2021
PG 6
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA XO5BW
UT WOS:000620432100001
PM 33619358
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Kelli, HM
   Corrigan, FE
   Heinl, RE
   Dhindsa, DS
   Hammadah, M
   Samman-Tahhan, A
   Sandesara, P
   O'Neal, WT
   Al Mheid, I
   Ko, YA
   Vaccarino, V
   Ziegler, TR
   Sperling, LS
   Brigham, K
   Jones, D
   Martin, GS
   Quyyumi, AA
AF Kelli, Heval M.
   Corrigan, Frank E., III
   Heinl, Robert E.
   Dhindsa, Devinder S.
   Hammadah, Muhammad
   Samman-Tahhan, Ayman
   Sandesara, Pratik
   O'Neal, Wesley T.
   Al Mheid, Ibhar
   Ko, Yi-An
   Vaccarino, Viola
   Ziegler, Thomas R.
   Sperling, Laurence S.
   Brigham, Kenneth
   Jones, Dean
   Martin, Greg S.
   Quyyumi, Arshed A.
TI Relation of Changes in Body Fat Distribution to Oxidative Stress
SO AMERICAN JOURNAL OF CARDIOLOGY
LA English
DT Article
ID ADIPOSE-TISSUE; INFLAMMATION; OBESITY; WOMEN; DISEASE; PREVENTION;
   RESISTANCE; BIOLOGY; RISK
AB Android fat is a surrogate measure of visceral obesity in the truncal region. Both visceral adiposity and oxidative stress (OS) are linked to cardiometabolic risk factors and clinical cardiovascular disease. However, whether body fat distribution (android vs gynoid) is associated with OS remains unknown. We hypothesized that increased android fat will be associated with greater OS. Body fat distribution and markers of OS, including plasma levels of reduced (cysteine and glutathione) and oxidized (cystine and glutathione disulfide) aminothiols, were estimated in 711 volunteers (67% female, 23% black, mean age 48 +/- 11) enrolled in the Emory Georgia Tech Predictive Health study. At 1 year, 498 subjects had repeat testing. At baseline, anthropometric and fat distribution indexes, including body mass index, waist circumference, weight/hip ratio, and android and gynoid fat mass correlated with lower plasma concentrations of glutathione and higher cystine levels indicative of higher OS. At 1 year, the change in android but not gynoid fat mass or body mass index negatively correlated with the change in the plasma glutathione level after adjustment for cardiovascular risk factors. Increased body fat, specifically android fat mass, is an independent determinant of systemic OS, and its change is associated with a simultaneous change in OS, measured as plasma glutathione. hi conclusion, our findings suggest that excess android or visceral fat contributes to the development of cardiovascular disease through modulating OS. (C) 2017 Published by Elsevier Inc.
C1 [Kelli, Heval M.; Corrigan, Frank E., III; Hammadah, Muhammad; Samman-Tahhan, Ayman; Sandesara, Pratik; O'Neal, Wesley T.; Al Mheid, Ibhar; Vaccarino, Viola; Ziegler, Thomas R.; Sperling, Laurence S.; Jones, Dean; Quyyumi, Arshed A.] Emory Univ, Emory Clin Cardiovasc Res Inst, Atlanta, GA 30322 USA.
   [Heinl, Robert E.; Dhindsa, Devinder S.; Ko, Yi-An; Vaccarino, Viola] Emory Univ, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA.
   [Brigham, Kenneth; Martin, Greg S.] Emory Univ, Predict Hlth Inst, Atlanta, GA 30322 USA.
C3 Emory University; Emory University; Rollins School Public Health; Emory
   University
RP Quyyumi, AA (corresponding author), Emory Univ, Emory Clin Cardiovasc Res Inst, Atlanta, GA 30322 USA.
EM aquyyum@emory.edu
RI Vaccarino, Viola/AAW-5600-2020; Stefanadis, Christodoulos/ABH-2232-2020;
   Martin, Greg/B-4085-2009
OI Stefanadis, Christodoulos/0000-0001-5974-6454; Martin,
   Greg/0000-0002-9684-7593; Vaccarino, Laura Viola/0000-0002-9054-0654
FU Marcus Foundation; Woodruff Foundation, Atlanta, Georgia; Emory
   University/Georgia Tech Predictive Health Institute; Clinical and
   Translational Science Award Program, the National Institutes of Health
   (NIH), the National Center for Research Resources [UL1 RR025008, UL1
   TR000454]; National Center for Advancing Translational Sciences; NIH
   [5P01HL101398-02, 1P20HL113451-01, 1R56HL126558-01, 1RF1AG051633-01, R01
   NS064162-01, R01 HL89650-01, HL095479-01, 1U10HL110302-01,
   1DP3DK094346-01, 2P01HL086773]; American Heart Association [0000031288];
   Abraham J. and Phyllis Katz Foundation; NHLBI [T32 THL130025A]
FX This work was supported by the Marcus and Woodruff Foundations, Atlanta,
   Georgia, and the Emory University/Georgia Tech Predictive Health
   Institute, and awards UL1 RR025008 and UL1 TR000454 from the Clinical
   and Translational Science Award Program, the National Institutes of
   Health (NIH), the National Center for Research Resources, and the
   National Center for Advancing Translational Sciences. Dr. Quyyumi is
   supported by NIH grants 5P01HL101398-02, 1P20HL113451-01,
   1R56HL126558-01, 1RF1AG051633-01, R01 NS064162-01, R01 HL89650-01,
   HL095479-01, 1U10HL110302-01, 1DP3DK094346-01, and 2P01HL086773, and
   American Heart Association grant no. 0000031288. HMK has been supported
   by the Abraham J. and Phyllis Katz Foundation and NHLBI T32 THL130025A.
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NR 26
TC 30
Z9 34
U1 0
U2 8
PU EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
PI BRIDGEWATER
PA 685 ROUTE 202-206 STE 3, BRIDGEWATER, NJ 08807 USA
SN 0002-9149
EI 1879-1913
J9 AM J CARDIOL
JI Am. J. Cardiol.
PD DEC 15
PY 2017
VL 120
IS 12
BP 2289
EP 2293
DI 10.1016/j.amjcard.2017.08.053
PG 5
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA FQ8PA
UT WOS:000418623600027
PM 29102347
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Ceolotto, G
   Papparella, I
   Lenzini, L
   Sartori, M
   Mazzoni, M
   Iori, E
   Franco, L
   Gallo, A
   de Kreutzenberg, SV
   Tiengo, A
   Pessina, AC
   Avogaro, A
   Semplicini, A
AF Ceolotto, Giulio
   Papparella, Italia
   Lenzini, Livia
   Sartori, Michelangelo
   Mazzoni, Martina
   Iori, Elisabetta
   Franco, Lorenzo
   Gallo, Alessandra
   de Kreutzenberg, Saula Vigili
   Tiengo, Antonio
   Pessina, Achille C.
   Avogaro, Angelo
   Semplicini, Andrea
TI Insulin generates free radicals in human fibroblasts ex vivo by a
   protein kinase C-dependent mechanism, which is inhibited by pravastatin
SO FREE RADICAL BIOLOGY AND MEDICINE
LA English
DT Article
DE hydroxymethylglutaryl-CoA reductase inhibitors; insulin; NADPH oxidase;
   PKC; p47(phox); reactive oxygen species
ID NADPH OXIDASE; H2O2-GENERATING SYSTEM; GLUCOSE-TRANSPORT; OXIDATIVE
   STRESS; NAD(P)H OXIDASE; ANGIOTENSIN-II; IN-VITRO; ACTIVATION;
   PHOSPHORYLATION; P47(PHOX)
AB Insulin can generate oxygen free radicals. Statins, 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors, exert a powerful antioxidant effect. The present study aimed to clarify the mechanisms through which insulin generates free radicals and to assess whether pravastatin modulazes such effects. In cultured skin fibroblasts from human volunteers exposed to high insulin concentration, either in the presence or in the absence of pravastatin, insulin induced translocation of the p47(phox) subunit of NAD(P)H oxidase from the cytosol to the membrane and generation of radical oxygen species through a PKC delta-dependent mechanism. The insulin-induced translocation of p47(phox) was PKC delta dependent and attenuated by pravastatin, but independent of the activation of Akt and Rac1. Insulin-induced Akt phosphorylation was increased by pravastatin and ERK1/2 phosphorylation attenuated. The present study demonstrates a novel mechanism by which insulin stimulates the generation of free radicals in human fibroblasts, ex vivo. It involves phosphatidylinositol 3-kinase, PKC delta, and p47(phox) translocation and promotes ERK1/2 phosphorylation. Pravastatin inhibited radical oxygen species production by inhibiting PKC 6. These observations offer a robust explanation for the positive effects of pravastatin treatment in patients with insulin resistance syndrome. (c) 2006 Elsevier Inc. All rights reserved.
C1 Univ Padua, Sch Med, Dept Clin & Expt Med, I-35128 Padua, Italy.
   Univ Padua, Dept Chem Sci, I-35131 Padua, Italy.
C3 University of Padua; University of Padua
RP Semplicini, A (corresponding author), Univ Padua, Sch Med, Dept Clin & Expt Med, Via Giustiniani 2, I-35128 Padua, Italy.
EM andrea.semplicini@unipd.it
RI de Kreutzenberg, S./AAA-4277-2022; Sartori, Michelangelo/JAC-7959-2023;
   Avogaro, Angelo/S-3808-2016; Semplicini, Andrea/B-5959-2013; Franco,
   Lorenzo/Q-6629-2017
OI Sartori, Michelangelo/0000-0003-3466-4676; Lenzini,
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   ANGELO/0000-0002-1177-0516; Franco, Lorenzo/0000-0003-3548-4423
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NR 43
TC 22
Z9 23
U1 0
U2 8
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0891-5849
EI 1873-4596
J9 FREE RADICAL BIO MED
JI Free Radic. Biol. Med.
PD AUG 1
PY 2006
VL 41
IS 3
BP 473
EP 483
DI 10.1016/j.freeradbiomed.2006.04.015
PG 11
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 068CO
UT WOS:000239349700011
PM 16843828
DA 2025-06-11
ER

PT J
AU Santacroce, G
   Gentile, A
   Soriano, S
   Novelli, A
   Lenti, MV
   Di Sabatino, A
AF Santacroce, Giovanni
   Gentile, Antonella
   Soriano, Simone
   Novelli, Andrea
   Lenti, Marco Vincenzo
   Di Sabatino, Antonio
TI Glutathione: Pharmacological aspects and implications for clinical use
   in non-alcoholic fatty liver disease
SO FRONTIERS IN MEDICINE
LA English
DT Review
DE chronic liver disorder; metabolic syndrome; non-alcoholic fatty liver
   disease; oxidative stress; oral glutathione
ID OXIDATIVE STRESS; INSULIN-RESISTANCE; INTESTINAL PERMEABILITY; CONFERS
   SUSCEPTIBILITY; ORAL GLUTATHIONE; BODY STORES; METABOLISM; DEPLETION;
   PATHOGENESIS; ASSOCIATION
AB Glutathione is a tripeptide synthesized at cytosolic level, that exists in cells in a reduced form (thiol-reduced-GSH-) and in an oxidized form (disulfide-oxidized). The antioxidant function of GSH has led to speculation about its therapeutic role in numerous chronic diseases characterized by altered redox balance and reduced GSH levels, including, for instance, neurodegenerative disorders, cancer, and chronic liver diseases. Among these latter, non-alcoholic fatty liver disease (NAFLD), characterized by lipid accumulation in hepatocytes, in the absence of alcohol abuse or other steatogenic factors, is one of the most prevalent. The umbrella term NAFLD includes the pure liver fat accumulation, the so-called hepatic steatosis or non-alcoholic fatty liver, and the progressive form with inflammation, also known as non-alcoholic steatohepatitis, which is related to the increase in oxidative stress and reactive oxygen species, eventually leading to liver fibrosis. Although the pathogenetic role of oxidative stress in these diseases is well established, there is still limited evidence on the therapeutic role of GSH in such conditions. Hence, the aim of this review is to depict the current molecular and pharmacological knowledge on glutathione, focusing on the available studies related to its therapeutic activity in NAFLD.
C1 [Santacroce, Giovanni; Gentile, Antonella; Soriano, Simone; Lenti, Marco Vincenzo; Di Sabatino, Antonio] Univ Pavia, Dept Internal Med & Med Therapeut, Pavia, Italy.
   [Santacroce, Giovanni; Gentile, Antonella; Soriano, Simone; Lenti, Marco Vincenzo; Di Sabatino, Antonio] San Matteo Hosp Fdn, Dept Internal Med 1, Pavia, Italy.
   [Novelli, Andrea] Univ Firenze, Dept Hlth Sci, Clin Pharmacol & Oncol Sect, Florence, Italy.
C3 University of Pavia; University of Florence
RP Di Sabatino, A (corresponding author), Univ Pavia, Dept Internal Med & Med Therapeut, Pavia, Italy.; Di Sabatino, A (corresponding author), San Matteo Hosp Fdn, Dept Internal Med 1, Pavia, Italy.
EM a.disabatino@smatteo.pv.it
RI Di Sabatino, Antonio/K-8015-2016; Lenti, Marco/F-9044-2018; Santacroce,
   Giovanni/LQB-8122-2024
OI Santacroce, Giovanni/0000-0002-0544-0414
FU San Matteo Hospital Foundation
FX This paper was supported by "San Matteo Hospital Foundation, Internal
   Medicine research fundings, PRIN2017."
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NR 80
TC 22
Z9 24
U1 4
U2 22
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 2296-858X
J9 FRONT MED-LAUSANNE
JI Front. Med.
PD MAR 22
PY 2023
VL 10
AR 1124275
DI 10.3389/fmed.2023.1124275
PG 9
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA C6OT0
UT WOS:000963094100001
PM 37035339
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Aghaei, M
   Dastghaib, S
   Aftabi, S
   Aghanoori, MR
   Alizadeh, J
   Mokarram, P
   Mehrbod, P
   Ashrafizadeh, M
   Zarrabi, A
   McAlinden, KD
   Eapen, MS
   Sohal, SS
   Sharma, P
   Zeki, AA
   Ghavami, S
AF Aghaei, Mahmoud
   Dastghaib, Sanaz
   Aftabi, Sajjad
   Aghanoori, Mohamad-Reza
   Alizadeh, Javad
   Mokarram, Pooneh
   Mehrbod, Parvaneh
   Ashrafizadeh, Milad
   Zarrabi, Ali
   McAlinden, Kielan Darcy
   Eapen, Mathew Suji
   Sohal, Sukhwinder Singh
   Sharma, Pawan
   Zeki, Amir A.
   Ghavami, Saeid
TI The ER Stress/UPR Axis in Chronic Obstructive Pulmonary Disease and
   Idiopathic Pulmonary Fibrosis
SO LIFE-BASEL
LA English
DT Review
DE endoplasmic reticulum; fibrosis; tissue remodeling; non-coding RNA; UPR;
   autophagy; lung disease
ID ENDOPLASMIC-RETICULUM STRESS; UNFOLDED PROTEIN RESPONSE; USUAL
   INTERSTITIAL PNEUMONIA; ALVEOLAR EPITHELIAL-CELLS; SOCIETY STATEMENT
   UPDATE; NONCODING RNAS; BAX INHIBITOR-1; MESSENGER-RNA; CIRCULATING
   FIBROCYTES; MITOCHONDRIAL DYNAMICS
AB Cellular protein homeostasis in the lungs is constantly disrupted by recurrent exposure to various external and internal stressors, which may cause considerable protein secretion pressure on the endoplasmic reticulum (ER), resulting in the survival and differentiation of these cell types to meet the increased functional demands. Cells are able to induce a highly conserved adaptive mechanism, known as the unfolded protein response (UPR), to manage such stresses. UPR dysregulation and ER stress are involved in numerous human illnesses, such as metabolic syndrome, fibrotic diseases, and neurodegeneration, and cancer. Therefore, effective and specific compounds targeting the UPR pathway are being considered as potential therapies. This review focuses on the impact of both external and internal stressors on the ER in idiopathic pulmonary fibrosis (IPF) and chronic obstructive pulmonary disease (COPD) and discusses the role of the UPR signaling pathway activation in the control of cellular damage and specifically highlights the potential involvement of non-coding RNAs in COPD. Summaries of pathogenic mechanisms associated with the ER stress/UPR axis contributing to IPF and COPD, and promising pharmacological intervention strategies, are also presented.
C1 [Aghaei, Mahmoud; Aftabi, Sajjad; Alizadeh, Javad; Ghavami, Saeid] Univ Manitoba, Dept Human Anat & Cell Sci, Rady Fac Hlth Sci, Dept Human Anat & Cell Sci,Max Rady Coll Med, Winnipeg, MB R3E 0J9, Canada.
   [Aghaei, Mahmoud] Isfahan Univ Med Sci, Sch Pharm & Pharmaceut Sci, Dept Clin Biochem, Esfahan 8174673461, Iran.
   [Dastghaib, Sanaz; Mokarram, Pooneh] Shiraz Univ Med Sci, Sch Med, Dept Clin Biochem, Shiraz 7134845794, Iran.
   [Dastghaib, Sanaz; Mokarram, Pooneh; Ghavami, Saeid] Shiraz Univ Med Sci, Autophagy Res Ctr, Shiraz 7134845794, Iran.
   [Aftabi, Sajjad] Univ Manitoba, Dept Med Phys, Canc Care Manitoba, Winnipeg, MB R3E 0V9, Canada.
   [Aghanoori, Mohamad-Reza] Univ Manitoba, Albrechtsen Res Ctr, St Boniface Hosp, Div Neurodegenerat Disorders, Winnipeg, MB R2H 2A6, Canada.
   [Aghanoori, Mohamad-Reza] Univ Manitoba, Dept Internal Med, Winnipeg, MB R3E 0V9, Canada.
   [Alizadeh, Javad; Ghavami, Saeid] Univ Manitoba, Canc Care Manitoba, Res Inst Oncol & Hematol, Winnipeg, MB R3E 0V9, Canada.
   [Alizadeh, Javad; Ghavami, Saeid] Univ Manitoba, Children Hosp Res Inst Manitoba, Biol Breathing Theme, Winnipeg, MB R3E 0V9, Canada.
   [Mehrbod, Parvaneh] Pasteur Inst Iran, Influenza & Resp Viruses Dept, Tehran 1316943551, Iran.
   [Ashrafizadeh, Milad] Sabanci Univ, Fac Engn & Nat Sci, Univ Caddesi 27, TR-34956 Istanbul, Turkey.
   [Ashrafizadeh, Milad; Zarrabi, Ali] Sabanci Univ, Nanotechnol Res & Applicat Ctr SUNUM, TR-34956 Istanbul, Turkey.
   [McAlinden, Kielan Darcy; Eapen, Mathew Suji; Sohal, Sukhwinder Singh] Univ Tasmania, Sch Hlth Sci, Dept Lab Med, Resp Translat Res Grp, Launceston, Tas 7250, Australia.
   [Sharma, Pawan] Thomas Jefferson Univ, Jane & Leonard Korman Resp Inst, Ctr Translat Med, Philadelphia, PA 19107 USA.
   [Zeki, Amir A.] Univ Calif Davis, Davis Sch Med, Dept Internal Med, Div Pulm Crit Care & Sleep Med,UC Davis Lung Ctr, Davis, CA 95616 USA.
   [Zeki, Amir A.] Vet Affairs Med Ctr, Mather, CA 95655 USA.
C3 University of Manitoba; Isfahan University of Medical Sciences; Shiraz
   University of Medical Science; Shiraz University of Medical Science;
   University of Manitoba; CancerCare Manitoba Foundation; University of
   Manitoba; Children's Hospital Research Institute of Manitoba; Saint
   Boniface Hospital; University of Manitoba; University of Manitoba;
   CancerCare Manitoba Foundation; University of Manitoba; Children's
   Hospital Research Institute of Manitoba; Pasteur Network; Pasteur
   Institute of Iran; Sabanci University; Sabanci University; University of
   Tasmania; Thomas Jefferson University; University of California System;
   University of California Davis; US Department of Veterans Affairs;
   Veterans Health Administration (VHA)
RP Ghavami, S (corresponding author), Univ Manitoba, Dept Human Anat & Cell Sci, Rady Fac Hlth Sci, Dept Human Anat & Cell Sci,Max Rady Coll Med, Winnipeg, MB R3E 0J9, Canada.; Ghavami, S (corresponding author), Shiraz Univ Med Sci, Autophagy Res Ctr, Shiraz 7134845794, Iran.; Ghavami, S (corresponding author), Univ Manitoba, Canc Care Manitoba, Res Inst Oncol & Hematol, Winnipeg, MB R3E 0V9, Canada.; Ghavami, S (corresponding author), Univ Manitoba, Children Hosp Res Inst Manitoba, Biol Breathing Theme, Winnipeg, MB R3E 0V9, Canada.
EM parsa16657@yahoo.com; suny.respina@gmail.com; aftabis@myumanitoba.ca;
   aghanoori@gmail.com; alizadej@myumanitoba.ca; mokaram2@gmail.com;
   mehrbode@yahoo.com; parsa16657@yahoo.com; aftabis@myumanitoba.ca;
   kielan.mcalinden@utas.edu.au; mathew.eapen@utas.edu.au;
   sssohal@utas.edu.au; pawan.sharma@jefferson.edu; aazeki@ucdavis.edu;
   saeid.ghavami@umanitoba.ca
RI Alizadeh, Javad/AAR-4824-2020; Sohal, Sukhwinder/J-7395-2014; Eapen,
   Mathew/AAB-9444-2021; Aghaei, Mahmoud/I-2308-2013; Ashrafizadeh,
   Milad/JGC-9775-2023; Ghavami, Saeid/Q-8918-2016; McAlinden,
   Kielan/ABC-7069-2021; Dastghaib, Sanaz/ABD-5899-2021; Aghanoori,
   Mohamad-Reza/AAC-8164-2021; Mokarram, Pooneh/E-1613-2012; Zarrabi,
   Ali/U-2602-2019; McAlinden, Kielan/C-5592-2018; Mehrbod,
   Parvaneh/I-4444-2017; Sharma, Pawan/D-4314-2016
OI Ghavami, Saeid/0000-0001-5948-508X; Dastghaib,
   Sanaz/0000-0001-8553-9221; aghaei, mahmoud/0000-0002-1775-8761; Eapen,
   Mathew/0000-0003-0570-7059; Mokarram, Pooneh/0000-0002-9717-0473;
   Alizadeh, Javad/0000-0001-9082-3083; Zarrabi, Ali/0000-0003-0391-1769;
   Sohal, Sukhwinder Singh/0000-0001-9627-6498; McAlinden,
   Kielan/0000-0002-4597-6491; Zeki, Amir/0000-0001-8901-588X; Mehrbod,
   Parvaneh/0000-0002-8391-9228; Sharma, Pawan/0000-0002-2904-2306;
   Aghanoori, Mohamad-Reza/0000-0003-1495-748X
FU Isfahan University of Medical Sciences; Vanier PhD Scholarship; CCMF
   grant; CIHR; Rebecca L Cooper Medical Research Foundation; UTS
   Chancellor Research Program; Clifford Craig Foundation Launceston
   General Hospital
FX M.A. salary is supported by Isfahan University of Medical Sciences. J.A.
   was supported by Vanier PhD Scholarship. S.A. was supported by
   studentship by CCMF grant awarded to S.G. and CIHR grant to Stephen
   Pistorius. P.S. was supported by Rebecca L Cooper Medical Research
   Foundation and UTS Chancellor Research Program. S.S.S. is supported by
   Clifford Craig Foundation Launceston General Hospital and Rebecca L
   Cooper Medical Research Foundation. Authors acknowledge Science Impact
   Winnipeg for language editing of the manuscript.
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NR 285
TC 37
Z9 38
U1 0
U2 7
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2075-1729
J9 LIFE-BASEL
JI Life-Basel
PD JAN
PY 2021
VL 11
IS 1
AR 1
DI 10.3390/life11010001
PG 27
WC Biology; Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics; Microbiology
GA PW0OX
UT WOS:000610378000001
PM 33374938
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Baret, P
   Le Sage, F
   Planesse, C
   Meilhac, O
   Devin, A
   Bourdon, E
   Rondeau, P
AF Baret, Pascal
   Le Sage, Fanny
   Planesse, Cynthia
   Meilhac, Olivier
   Devin, Anne
   Bourdon, Emmanuel
   Rondeau, Philippe
TI Glycated human albumin alters mitochondrial respiration in preadipocyte
   3T3-L1 cells
SO BIOFACTORS
LA English
DT Article
DE mitochondria biogenesis; advanced glycation end products; 3T3-L1
   pre-adipocytes; oxidative stress; AGE
ID INCREASED OXIDATIVE STRESS; BOVINE SERUM-ALBUMIN; END-PRODUCTS;
   INSULIN-RESISTANCE; PGC-1-ALPHA; ADIPOCYTES; DYSFUNCTION;
   DIFFERENTIATION; BIOGENESIS; METABOLISM
AB Diabetes and obesity are strongly associated with increased levels of circulating advanced glycation end products (AGEs) and reactive oxygen species (ROS). These two molecular phenomena affect the physiology of adipose tissue, a biological driver of the metabolic syndrome, leading to an inflammatory profile and insulin resistance, which could contribute to obesity/diabetes-associated complications, such as cardiovascular diseases. Herein, we investigated the impact of AGEs on mitochondrial bioenergetics in murine preadipocyte cells (3T3-L1) and cellular redox homeostasis. We show that incubation of preadipocytes with AGEs stimulates mitochondrial activity and respiration while inducing oxidative stress. This AGE-induced intracellular ROS production was blocked by diphenylene iodonium, an NAD(P)H oxidase inhibitor. In parallel, antioxidant enzymes (catalase, superoxide dismutase, and glutathione peroxidase) were found to be activated upon AGE treatment. Our results suggest that AGE-induced oxidative stress is generated by NAD(P)H oxidase and leads to a cellular proliferation arrest associated with enhanced mitochondrial metabolism and biogenesis, and with increased levels of ROS-detoxifying enzymes, as well. These new data show how AGEs may be involved in hyperglycemia-induced oxidative damage in preadipocytes and their potential links to diabetes progression. (c) 2017 BioFactors, 43(4):577-592, 2017
C1 [Baret, Pascal; Le Sage, Fanny; Planesse, Cynthia; Meilhac, Olivier; Bourdon, Emmanuel; Rondeau, Philippe] INSERM, UMR Diabet Atherothrombose Therapies Reunion Ocea, Plateforme CYROI, St Clotilde, Reunion, France.
   [Baret, Pascal; Le Sage, Fanny; Planesse, Cynthia; Meilhac, Olivier; Bourdon, Emmanuel; Rondeau, Philippe] Univ La Reunion, UMR 1188, St Clotilde, Reunion, France.
   [Meilhac, Olivier] CHU La Reunion, Ctr Invest Clin, St Denis, Reunion, France.
   [Devin, Anne] Univ Bordeaux, CNRS, Inst Biochim & Genet Cellulaires, UMR 5095, Bordeaux, France.
C3 Institut National de la Sante et de la Recherche Medicale (Inserm);
   University of La Reunion; CHU Reunion; Institut National de la Sante et
   de la Recherche Medicale (Inserm); Centre National de la Recherche
   Scientifique (CNRS); Universite de Bordeaux; CNRS - National Institute
   for Biology (INSB)
RP Bourdon, E; Rondeau, P (corresponding author), Univ Reunion, DeTROI, CYROI, 2 Rue Maxime Riviere,BP 80 005, F-97491 St Clotilde, Reunion, France.
EM emmanuel.bourdon@univ-reunion.fr; rophil@univ-reunion.fr
RI rondeau, philippe/Q-1967-2019; Meilhac, Olivier/N-4385-2017; Bourdon,
   Emmanuel/P-8455-2019
OI Meilhac, Olivier/0000-0002-3740-7539; Bourdon,
   Emmanuel/0000-0003-3731-150X
FU Ministere de l'Enseignement Superieur et de la Recherche; Ministere de
   l'Outre-Mer; Conseil Regional de La Reunion; Europe, the Universite de
   La Reunion; federation Environnement Biodiversite Sante- [FED4126];
   Ministere de l'enseignement superieur et la Recherche
FX This work was supported by the Ministere de l'Enseignement Superieur et
   de la Recherche, the Ministere de l'Outre-Mer, the Conseil Regional de
   La Reunion and Europe, the Universite de La Reunion and the federation
   Environnement Biodiversite Sante- FED4126. FL is supported by a
   fellowship from the Ministere de l'enseignement superieur et la
   Recherche.
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NR 64
TC 6
Z9 6
U1 0
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0951-6433
EI 1872-8081
J9 BIOFACTORS
JI Biofactors
PD JUL-AUG
PY 2017
VL 43
IS 4
BP 577
EP 592
DI 10.1002/biof.1367
PG 16
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA FD5YL
UT WOS:000407605700013
PM 28543688
DA 2025-06-11
ER

PT J
AU Ren, DY
   Zhao, Y
   Nie, Y
   Lu, XS
   Sun, YF
   Yang, XB
AF Ren, Daoyuan
   Zhao, Yan
   Nie, Yan
   Lu, Xinshan
   Sun, Yanfei
   Yang, Xingbin
TI Chemical composition of Pleurotus eryngii polysaccharides
   and their inhibitory effects on high-fructose diet-induced insulin
   resistance and oxidative stress in mice
SO FOOD & FUNCTION
LA English
DT Article
ID TEA POLYSACCHARIDES; METABOLIC SYNDROME; HOMA-IR; EXTRACT; RATS;
   ANTIOXIDANT; ANTITUMOR; HDL
AB High intake of dietary fructose exerts a number of adverse metabolic effects. The present study investigates the preventive effects of Pleurotus eryngii polysaccharides (PEP), which showed powerful antioxidant activity in vitro, on insulin resistance and oxidative stress in mice fed a high-fructose diet. PEP was identified by HPLC as the heteropolysaccharides with ID-glucose (62.8%, mol%), D.-galactose (24.4%) and D-mannose (9.8%) being the main component monosaccharides. Mice fed 20% fructose in drinking water for 6 weeks significantly displayed hyperglycemia, hyperinsulinemia, dyslipidemia and liver oxidative stress with impaired insulin sensitivity (p < 0.05). The administration of PEP at 400 and 800 mg kg(-1) bw significantly reduced the fasting serum glucose and insulin concentrations and lipid deposition in HF-fed mice, and caused the reduction of liver lipid peroxidation and the elevation of the hepatic antioxidant system. The histopathology of the liver by conventional H&E and oil red 0 staining confirmed the liver steatosis induced by a HF diet and the hepatoprotective effect of PEP. These results suggest that Pleurotus eryngii is a potential source of polysaccharides, and might be regarded as a novel preventive and therapeutic product for the mitigation of insulin resistance, oxidative stress and liver dysfunction.
C1 [Ren, Daoyuan; Nie, Yan; Lu, Xinshan; Sun, Yanfei; Yang, Xingbin] Shaanxi Normal Univ, Coll Food Engn & Nutr Sci, Key Lab Minist Educ Med Resource & Nat Pharmaceut, Xian 710062, Peoples R China.
   [Zhao, Yan] Fourth Mil Med Univ, Sch Pharm, Xian 710032, Peoples R China.
C3 Shaanxi Normal University; Air Force Medical University
RP Yang, XB (corresponding author), Shaanxi Normal Univ, Coll Food Engn & Nutr Sci, Key Lab Minist Educ Med Resource & Nat Pharmaceut, Xian 710062, Peoples R China.
EM xbyang@snnu.edu.cn
RI Sun, Yanfei/I-7946-2018
FU National Natural Science Foundation of China [C31171678]; Fundamental
   Research Funds for the Central Universities of Shaanxi Normal
   University, China [GK201103004]
FX This study was supported by the grants from the National Natural Science
   Foundation of China (C31171678), and the Fundamental Research Funds for
   the Central Universities of Shaanxi Normal University, China
   (GK201103004).
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NR 32
TC 34
Z9 36
U1 1
U2 55
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PD OCT
PY 2014
VL 5
IS 10
BP 2609
EP 2620
DI 10.1039/c3fo60640f
PG 12
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA AQ7TY
UT WOS:000343023300027
PM 25157382
DA 2025-06-11
ER

PT J
AU Jaiswal, N
   Maurya, CK
   Pandey, J
   Rai, AK
   Tamrakar, AK
AF Jaiswal, N.
   Maurya, C. K.
   Pandey, J.
   Rai, A. K.
   Tamrakar, A. K.
TI Fructose-induced ROS generation impairs glucose utilization in L6
   skeletal muscle cells
SO FREE RADICAL RESEARCH
LA English
DT Article
DE insulin resistance; nutrient signal; stress kinase; oxidative stress
ID INSULIN-RECEPTOR SUBSTRATE-1; OXIDATIVE STRESS; INFLAMMATORY MECHANISMS;
   NEGATIVE REGULATION; VISCERAL ADIPOSITY; SIGNALING PATHWAYS;
   LIPID-METABOLISM; REACTIVE OXYGEN; RESISTANCE; GLUT5
AB High fructose consumption has implicated in insulin resistance and metabolic syndrome. Fructose is a highly lipogenic sugar that has intense metabolic effects in liver. Recent evidences suggest that fructose exposure to other tissues has substantial and profound metabolic consequences predisposing toward chronic conditions such as type 2 diabetes. Since skeletal muscle is the major site for glucose utilization, in the present study we define the effects of fructose exposure on glucose utilization in skeletal muscle cells. Upon fructose exposure, the L6 skeletal muscle cells displayed diminished glucose uptake, glucose transporter type 4 (GLUT4) translocation, and impaired insulin signaling. The exposure to fructose elevated reactive oxygen species (ROS) production in L6 myotubes, accompanied by activation of the stress/inflammation markers c-Jun N-terminal kinase (JNK) and extracellular signal-regulated kinase 1/2 (ERK1/2), and degradation of inhibitor of NF-kappa B (I kappa B alpha). We found that fructose caused impairment of glucose utilization and insulin signaling through ROS-mediated activation of JNK and ERK1/2 pathways, which was prevented in the presence of antioxidants. In conclusion, our data demonstrate that exposure to fructose induces cell-autonomous oxidative response through ROS production leading to impaired insulin signaling and attenuated glucose utilization in skeletal muscle cells.
C1 [Jaiswal, N.; Maurya, C. K.; Pandey, J.; Rai, A. K.; Tamrakar, A. K.] CSIR Cent Drug Res Inst, Div Biochem, Lucknow 226031, Uttar Pradesh, India.
C3 Council of Scientific & Industrial Research (CSIR) - India; CSIR -
   Central Drug Research Institute (CDRI)
RP Tamrakar, AK (corresponding author), CSIR Cent Drug Res Inst, Div Biochem, Sect 10,Sitapur Rd, Lucknow 226031, Uttar Pradesh, India.
EM akhilesh_tamrakar@cdri.res.in
RI Maurya, Chandan/AAV-1813-2021
OI Jaiswal, Natasha/0000-0003-4666-5430; Pandey,
   Jyotsana/0000-0002-0606-6903; Maurya, Chandan Kumar/0000-0003-2581-7415
FU Senior Research Fellowship of the University Grants Commission (UGC),
   New Delhi; Council of Industrial and Scientific Research (CSIR), New
   Delhi, India [BSC0102]
FX The authors would like to thank Dr. Amira Klip for providing L6 and
   L6-GLUT4myc cells. NJ and CKM are supported by Senior Research
   Fellowship of the University Grants Commission (UGC), New Delhi. We are
   thankful to Mr. A.L. Vishwakarma, SAIF Division for flow cytometric
   analysis. This manuscript bears the CDRI communication No. 8950. The
   authors are thankful for financial support from the Council of
   Industrial and Scientific Research (CSIR), New Delhi, India in the form
   of network project THUNDER (BSC0102)
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NR 62
TC 34
Z9 35
U1 0
U2 14
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1071-5762
EI 1029-2470
J9 FREE RADICAL RES
JI Free Radic. Res.
PY 2015
VL 49
IS 9
BP 1055
EP 1068
DI 10.3109/10715762.2015.1031662
PG 14
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA CQ6KW
UT WOS:000360714300002
PM 25968943
DA 2025-06-11
ER

PT J
AU Tada, F
   Abe, M
   Kawasaki, K
   Miyake, T
   Shiyi, C
   Hiasa, Y
   Matsuura, B
   Onji, M
AF Tada, Fujimasa
   Abe, Masanori
   Kawasaki, Keitarou
   Miyake, Teruki
   Shiyi, Chen
   Hiasa, Yoichi
   Matsuura, Bunzo
   Onji, Morikazu
TI B cell activating factor in obesity is regulated by oxidative stress in
   adipocytes
SO JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION
LA English
DT Article
DE B cell activation factor; adipocytes; obesity; oxidative stress; nuclear
   factor-kappa B
ID NF-KAPPA-B; NECROSIS-FACTOR FAMILY; BODY-MASS INDEX; INSULIN-RESISTANCE;
   ADIPOSE-TISSUE; LYMPHOCYTE STIMULATOR; METABOLIC SYNDROME; INFLAMMATION;
   EXPRESSION; BAFF
AB Adipose tissue functions as a key endocrine organ by releasing multiple bioactive substances, and plays a key role in the integration of systemic metabolism. We have previously shown that B cell activating factor is produced mainly in visceral adipose tissue and affects insulin sensitivity in obese individuals. In this study, we identified the signals that lead to production of B cell activating factor in adipocytes. 3T3-L1 and C3H/10T 1/2-clone 8 cells showed increased B cell activating factor expression upon exposure to hydrogen peroxide, and these changes were inhibited by treatment with the antioxidant N-acetyl-cysteine. B cell activating factor levels in both serum and visceral adipose tissue were increased in high fat diet-fed mice, and these increases were correlated with oxidative stress. In addition, serum BAFF levels in high fat diet-fed mice were reduced by N-acetyl-cysteine treatment. We also found that oxidative stress-induced B cell activating factor expression in adipocytes was regulated by NF-kappa B activation. These data indicate that control of the redox state in visceral adipose tissue is a potentially useful target for treating metabolic syndromes through regulation of adipokine production.
C1 [Tada, Fujimasa; Abe, Masanori; Kawasaki, Keitarou; Miyake, Teruki; Shiyi, Chen; Hiasa, Yoichi; Matsuura, Bunzo; Onji, Morikazu] Ehime Univ, Grad Sch Med, Dept Gastroenterol & Metabol, Toon, Ehime 7910295, Japan.
C3 Ehime University
RP Abe, M (corresponding author), Ehime Univ, Grad Sch Med, Dept Gastroenterol & Metabol, Toon, Ehime 7910295, Japan.
EM masaben@m.ehime-u.ac.jp
RI Miyake, Teruki/LLM-2002-2024; Hiasa, Yoichi/ABD-2759-2021
OI Chen, Shiyi/0000-0001-9190-3122; Miyake, Teruki/0000-0002-9905-5356
FU Japanese Ministry of Education, Culture, Sports, Science and Technology
   (JSPS KAKENHI) [24590979]; Ehime University; Grants-in-Aid for
   Scientific Research [24590979] Funding Source: KAKEN
FX We thank Mr. Kenji Tanimoto, Ms. Sawa Yamamoto, and Ms. Sakiko Sugawara
   for their valuable contributions to this study. This research was
   supported in part by Grants-in-Aid for Scientific Research from the
   Japanese Ministry of Education, Culture, Sports, Science and Technology
   (JSPS KAKENHI 24590979) and a research grant from Ehime University.
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NR 39
TC 14
Z9 15
U1 0
U2 6
PU JOURNAL CLINICAL BIOCHEMISTRY & NUTRITION
PI KYOTO
PA KYOTO PREFECTURAL UNIV MED, GRAD SCH MEDICAL SCIENCE, DEPT MOLECULAR
   GASTROENTEROLOGY & HEPATOLOGY, KYOTO, 602-8566, JAPAN
SN 0912-0009
EI 1880-5086
J9 J CLIN BIOCHEM NUTR
JI J. Clin. Biochem. Nutr.
PD MAR 1
PY 2013
VL 52
IS 2
BP 120
EP 127
DI 10.3164/jcbn.12-115
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 295WG
UT WOS:000330146500005
PM 23525857
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Popescu, R
   Bild, W
   Ciobica, A
   Bild, V
AF Popescu, Raducu
   Bild, Walther
   Ciobica, Alin
   Bild, Veronica
TI New evidence for vascular interactions between aldosterone, angiotensin
   II and antioxidants in isolated smooth muscle cells of rats
SO CENTRAL EUROPEAN JOURNAL OF MEDICINE
LA English
DT Article
DE Aldosterone; Angiotensin II; Antioxidants; Smooth muscle; Rat
   Cardiorenal Metabolic Syndrome
ID CONGESTIVE-HEART-FAILURE; OXIDATIVE STRESS; NITRIC-OXIDE; NADPH OXIDASE;
   SPIRONOLACTONE; EPLERENONE; ANTAGONISM; ACTIVATION; RADICALS; DISEASE
AB Accumulating evidence suggests that the nongenomic cardiovascular actions of aldosterone are produced by varied cellular pathways and mediated by a multitude of messenger systems including the reactive oxygen and nitrogen species. Considering the involvement of the oxidative and nitrosative stress in the pathways leading to the activation of the angiotensin - aldosterone system, in the current study we tried to evaluate the functional interactions between aldosterone, angiotensin II and antioxidants in isolated vascular smooth muscle of aortic rings from rats. Our data provide additional arguments that the nongenomic actions of aldosterone on aortic smooth muscle cells of rats are a question of cross-talk and balance between its rapid vasoconstrictor and vasodilator effects, as result of the activation of reactive oxygen species in the first case and of nitrogen species in the second. In this way, it seems that at low ambient oxidative stress, aldosterone promotes nitric oxide (NO) production and vasodilatation, while in situations with increased oxidative stress the endothelial dysfunction and detrimental effects induced by vasoconstriction will prevail. Thus, aldosterone could be considered both "friend and foe". This could be relevant for the ways in which aldosterone damages cardiovascular functions and could lead to significant therapeutic improvements.
C1 [Popescu, Raducu; Bild, Walther; Bild, Veronica] Gr T Popa Univ Med & Pharm, Iasi 700115, Romania.
   [Bild, Walther; Ciobica, Alin; Bild, Veronica] Acad Romana, Ctr Biomed Res, Iasi Branch, Iasi 700115, Romania.
   [Ciobica, Alin] Alexandru Ioan Cuza Univ, Iasi 700506, Romania.
C3 Grigore T Popa University of Medicine & Pharmacy; Romanian Academy;
   Alexandru Ioan Cuza University
RP Bild, W (corresponding author), Gr T Popa Univ Med & Pharm, Str Univ 16, Iasi 700115, Romania.
EM wbild@rdslink.ro
RI Bild, Veronica/R-8657-2017; Bild, Walther/AAN-5061-2021; Ciobica,
   Alin/B-6073-2012; Bild, Walther/G-2890-2016
OI Bild, Walther/0000-0003-4923-8020
FU POSDRU, Alexandru Ioan Cuza University, Iasi [/89/1.5/S/49944]
FX Ciobica Alin is supported by a POSDRU grant /89/1.5/S/49944, "Developing
   the innovation capacity and improving the impact of research through
   post-doctoral programs" Alexandru Ioan Cuza University, Iasi.
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NR 36
TC 0
Z9 0
U1 0
U2 20
PU VERSITA
PI WARSAW
PA SOLIPSKA 14A-1, 02-482 WARSAW, POLAND
SN 1895-1058
J9 CENT EUR J MED
JI Cent. Eur. J. Med.
PD DEC
PY 2012
VL 7
IS 6
BP 704
EP 712
DI 10.2478/s11536-012-0059-z
PG 9
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 021AK
UT WOS:000309857500003
OA hybrid
DA 2025-06-11
ER

PT J
AU Locatelli, M
   Macconi, D
   Corna, D
   Cerullo, D
   Rottoli, D
   Remuzzi, G
   Benigni, A
   Zoja, C
AF Locatelli, Monica
   Macconi, Daniela
   Corna, Daniela
   Cerullo, Domenico
   Rottoli, Daniela
   Remuzzi, Giuseppe
   Benigni, Ariela
   Zoja, Carlamaria
TI Sirtuin 3 Deficiency Aggravates Kidney Disease in Response to High-Fat
   Diet through Lipotoxicity-Induced Mitochondrial Damage
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE high-fat-diet; sirtuin 3; oxidative stress; mitochondrial damage;
   lipotoxicity; kidney damage
ID RENAL LIPID-ACCUMULATION; METABOLIC SYNDROME; ACID OXIDATION; ATP
   SYNTHASE; OBESITY; EXPRESSION; CYCLE
AB Sirtuin 3 (SIRT3) is the primary mitochondrial deacetylase that controls the antioxidant pathway and energy metabolism. We previously found that renal Sirt3 expression and activity were reduced in mice with type 2 diabetic nephropathy associated with oxidative stress and mitochondrial abnormalities and that a specific SIRT3 activator improved renal damage. SIRT3 is modulated by diet, and to assess whether Sirt3 deficiency aggravates mitochondrial damage and accelerates kidney disease in response to nutrient overloads, wild-type (WT) and Sirt3(-/-) mice were fed a high-fat-diet (HFD) or standard diet for 8 months. Sirt3(-/-) mice on HFD exhibited earlier and more severe albuminuria compared to WT mice, accompanied by podocyte dysfunction and glomerular capillary rarefaction. Mesangial matrix expansion, tubular vacuolization and inflammation, associated with enhanced lipid accumulation, were more evident in Sirt3(-/-) mice. After HFD, kidneys from Sirt3(-/-) mice showed more oxidative stress than WT mice, mitochondria ultrastructural damage in tubular cells, and a reduction in mitochondrial mass and energy production. Our data demonstrate that Sirt3 deficiency renders mice more prone to developing oxidative stress and mitochondrial abnormalities in response to HFD, resulting in more severe kidney diseases, and this suggests that mitochondria protection may be a method to prevent HFD-induced renal injury.
C1 [Locatelli, Monica; Macconi, Daniela; Corna, Daniela; Cerullo, Domenico; Rottoli, Daniela; Remuzzi, Giuseppe; Benigni, Ariela; Zoja, Carlamaria] Ist Ric Farmacol Mario Negri IRCCS, Ctr Anna Maria Astori, Sci & Technol Pk Kilometro Rosso, I-24126 Bergamo, Italy.
C3 Istituto di Ricerche Farmacologiche Mario Negri IRCCS
RP Locatelli, M (corresponding author), Ist Ric Farmacol Mario Negri IRCCS, Ctr Anna Maria Astori, Sci & Technol Pk Kilometro Rosso, I-24126 Bergamo, Italy.
EM monica.locatelli@marionegri.it; daniela.macconi@marionegri.it;
   daniela.corna@marionegri.it; domenico.cerullo@marionegri.it;
   daniela.rottoli@marionegri.it; giuseppe.remuzzi@marionegri.it;
   ariela.benigni@marionegri.it; carlamaria.zoja@marionegri.it
RI Rottoli, Daniela/ABF-4290-2020; Locatelli, Monica/JBR-9315-2023; Corna,
   Daniela/ABF-4496-2020; Cerullo, Domenico/JAC-4748-2023; Remuzzi,
   Giuseppe/V-9766-2017
OI Locatelli, Monica/0000-0002-1395-3172; Cerullo,
   Domenico/0000-0001-9806-6443
FU Fondazione Cariplo [Rif 2016-0500]
FX The study was partially supported by Fondazione Cariplo (grant Giovani
   Ricercatori 2016, Rif 2016-0500).
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NR 45
TC 15
Z9 16
U1 0
U2 12
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD AUG
PY 2022
VL 23
IS 15
AR 8345
DI 10.3390/ijms23158345
PG 15
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 3R9LP
UT WOS:000839226400001
PM 35955472
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Nistala, R
   Habibi, J
   Aroor, A
   Sowers, JR
   Hayden, MR
   Meuth, A
   Knight, W
   Hancock, T
   Klein, T
   DeMarco, VG
   Whaley-Connell, A
AF Nistala, Ravi
   Habibi, Javad
   Aroor, Annayya
   Sowers, James R.
   Hayden, Melvin R.
   Meuth, Alex
   Knight, William
   Hancock, Tamara
   Klein, Thomas
   DeMarco, Vincent G.
   Whaley-Connell, Adam
TI DPP4 Inhibition Attenuates Filtration Barrier Injury and Oxidant Stress
   in the Zucker Obese Rat
SO OBESITY
LA English
DT Article
ID DIPEPTIDYL PEPTIDASE-4; OXIDATIVE STRESS; INSULIN-RESISTANCE; METABOLIC
   SYNDROME; KIDNEY; IV; PREVALENCE; OVERWEIGHT; DISEASE; BI-1356
AB ObjectiveObesity-related glomerulopathy is characterized initially by glomerular hyperfiltration with hypertrophy and then development of proteinuria. Putative mechanisms include endothelial dysfunction and filtration barrier injury due to oxidant stress and immune activation. There has been recent interest in targeting dipeptidyl peptidase 4 (DPP4) enzyme due to increasing role in non-enzymatic cellular processes.
   MethodsThe Zucker obese (ZO) rat (aged 8 weeks) fed a normal chow or diet containing the DPP4 inhibitor linagliptin for 8 weeks (83 mg/kg rat chow) was utilized.
   ResultsCompared to lean controls, there were increases in plasma DPP4 activity along with proteinuria in ZO rats. ZO rats further displayed increases in glomerular size and podocyte foot process effacement. These findings occurred in parallel with decreased endothelial stromal-derived factor-1 (SDF-1), increased oxidant markers, and tyrosine phosphorylation of nephrin and serine phosphorylation of the mammalian target of rapamycin (mTOR). DPP4 inhibition improved proteinuria along with filtration barrier remodeling, circulating and kidney tissue DPP4 activity, increased active glucagon like peptide-1 (GLP-1) as well as SDF-1, and improved oxidant markers and the podocyte-specific protein nephrin.
   ConclusionsThese data support a role for DPP4 in glomerular filtration function and targeting DPP4 with inhibition improves oxidant stress-related glomerulopathy and associated proteinuria.
C1 [Nistala, Ravi; Habibi, Javad; Aroor, Annayya; Sowers, James R.; Hayden, Melvin R.; Meuth, Alex; Knight, William; DeMarco, Vincent G.; Whaley-Connell, Adam] Univ Missouri, Sch Med, Columbia, MO 65211 USA.
   [Nistala, Ravi; Habibi, Javad; Aroor, Annayya; Sowers, James R.; Hayden, Melvin R.; Meuth, Alex; Knight, William; DeMarco, Vincent G.; Whaley-Connell, Adam] Diabet & Cardiovasc Ctr, Columbia, MO USA.
   [Nistala, Ravi; Habibi, Javad; Aroor, Annayya; Sowers, James R.; Hayden, Melvin R.; Meuth, Alex; Knight, William; DeMarco, Vincent G.; Whaley-Connell, Adam] Dept Internal Med, Columbia, MO USA.
   [Nistala, Ravi; Meuth, Alex; Whaley-Connell, Adam] Div Nephrol & Hypertens, Columbia, MO USA.
   [Nistala, Ravi; Habibi, Javad; Aroor, Annayya; Sowers, James R.; Meuth, Alex; Knight, William; Hancock, Tamara; DeMarco, Vincent G.; Whaley-Connell, Adam] Harry S Truman Mem Vet Hosp, Columbia, MO 65201 USA.
   [Habibi, Javad; Aroor, Annayya; Sowers, James R.; Hayden, Melvin R.; Knight, William; DeMarco, Vincent G.; Whaley-Connell, Adam] Div Endocrinol & Metab, Columbia, MO USA.
   [Sowers, James R.; DeMarco, Vincent G.] Dept Med Pharmacol & Physiol, Columbia, MO USA.
   [Hancock, Tamara] Univ Missouri, Coll Vet Med, Columbia, MO USA.
   [Klein, Thomas] Boehringer Ingelheim GmbH & Co KG, Ingelheim, Germany.
C3 University of Missouri System; University of Missouri Columbia;
   University of Missouri System; University of Missouri Columbia;
   University of Missouri System; University of Missouri Columbia; US
   Department of Veterans Affairs; Veterans Health Administration (VHA);
   Harry S. Truman Memorial Veterans' Hospital; University of Missouri
   System; University of Missouri Columbia; Boehringer Ingelheim
RP Nistala, R (corresponding author), Univ Missouri, Sch Med, Columbia, MO 65211 USA.
EM nistalar@health.missouri.edu
OI DeMarco, Vincent/0000-0003-2092-9995; Knight,
   William/0000-0002-1481-676X; Whaley-Connell, Adam/0000-0001-8955-5560
FU Boehringer Ingelheim Pharma; NIH [HL73101, HL1079100, AG040638];
   Veterans Affairs Merit System [0018, CDA-2]; American Society of
   Nephrology-Association of Specialty Professors (ASN-ASP) Development
   Grant in Geriatric Nephrology; T. Franklin Williams Scholarship Award -
   Atlantic Philanthropies, the John A. Hartford Foundation; Dialysis
   Clinics
FX This research was supported by an investigator initiated grant from
   Boehringer Ingelheim Pharma to VGD; NIH HL73101 and HL1079100 to JRS and
   AG040638 to AWC, the Veterans Affairs Merit System (0018) for JRS and
   CDA-2 for AWC, and the American Society of Nephrology-Association of
   Specialty Professors (ASN-ASP) Development Grant in Geriatric Nephrology
   to AWC was supported by a T. Franklin Williams Scholarship Award,
   funding provided by Atlantic Philanthropies, the John A. Hartford
   Foundation. Research support was also provided to RN by Dialysis
   Clinics.
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NR 39
TC 62
Z9 66
U1 0
U2 14
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1930-7381
EI 1930-739X
J9 OBESITY
JI Obesity
PD OCT
PY 2014
VL 22
IS 10
BP 2172
EP 2179
DI 10.1002/oby.20833
PG 8
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA AQ4ET
UT WOS:000342746800012
PM 24995775
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Neri-Flores, V
   Torres-Domínguez, JA
   Mohar-Betancourt, A
   Rodríguez-Ortiz, MD
   Castro-Sánchez, A
   Gálvez-Hernández, CL
AF Neri-Flores, Veronica
   Alejandro Torres-Dominguez, Juan
   Mohar-Betancourt, Alejandro
   Dolores Rodriguez-Ortiz, Maria
   Castro-Sanchez, Andrea
   Lizette Galvez-Hernandez, Carmen
TI Psychophysiological stress response of newly-diagnosed breast cancer
   patients with and without risk of metabolic syndrome
SO SALUD MENTAL
LA English
DT Article
DE Breast cancer; comorbidity; stress; psychophysiology; clinical
   psychology
ID QUALITY-OF-LIFE; MEXICAN-SPANISH VERSION; EUROPEAN-ORGANIZATION; WOMEN;
   QUESTIONNAIRES; VALIDATION; QLQ-C30; CARE
AB Introduction. Little is known about how metabolic comorbidity affects stress response during breast cancer (BRCa) after a recent diagnosis. Objective. To evaluate the physiological and psychological differences between the BRCa-RSxM groups and those with BRCa alone, and the influence of psychological variables and comorbidity in terms of stress response. Method. Comparative non-experimental causal-descriptive study. Fifty patients recently diagnosed with BRCa (25 with BRCa and 25 with BRCa-RSxM) in a convenience sample participated. Frontal muscle activity and skin conductance were recorded in response to stressful conditions. Quality of life, perceived stress, and coping strategies scales were used. Results. The presence of comorbidity (p = .001; p = .02), perceived stress (p = .004; p = .03), and social quality of life (p = .01; p = .01) influenced muscle activation and conductance during the emotional stressor (ES). Putting the stressful situation into perspective as a cognitive coping strategy was related to a decrease in activation (p = .04). An increase in physiological activation during the cognitive stressor (CS) was influenced by comorbidity (p = .05) and quality of social life (p = .01; p = .01). In turn, a decrease was influenced by the increase in age (p = .02). Discussion. Physiological vulnerability, coping strategies (behavioral and cognitive), and prior learning influenced the resulting reaction during the stressful situation. Conclusion. A metabolic disease, as a prelude to an oncological, may cause physiological vulnerability to respond adequately to stressful conditions.
C1 [Neri-Flores, Veronica] Univ Nacl Autonoma Mexico, Fac Psicol, Posgrad Psicol, Mexico City, DF, Mexico.
   [Alejandro Torres-Dominguez, Juan] Inst Nacl Cancerol, Unidad Epidemiol, Mexico City, DF, Mexico.
   [Mohar-Betancourt, Alejandro] Inst Nacl Cancerol, Programa Nacl Canc, Mexico City, DF, Mexico.
   [Dolores Rodriguez-Ortiz, Maria] Univ Nacl Autonoma Mexico, Fac Psicol, Lab Psicofisiol Aplicada, Mexico City, DF, Mexico.
   [Castro-Sanchez, Andrea; Lizette Galvez-Hernandez, Carmen] Inst Nacl Cancerol, Catedras CONACyT INCan, Ave San Fernando 22 Col Secc 16, Mexico City 14080, DF, Mexico.
C3 Universidad Nacional Autonoma de Mexico; Instituto Nacional de
   Cancerologia (INCAN); Instituto Nacional de Cancerologia (INCAN);
   Universidad Nacional Autonoma de Mexico; Instituto Nacional de
   Cancerologia (INCAN)
RP Gálvez-Hernández, CL (corresponding author), Inst Nacl Cancerol, Catedras CONACyT INCan, Ave San Fernando 22 Col Secc 16, Mexico City 14080, DF, Mexico.
EM lizettegalvezh@gmail.com
OI Neri Flores, Veronica/0000-0001-7998-5559
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   [No title captured]
   [No title captured]
   [No title captured]
   [No title captured]
   [No title captured]
   [No title captured]
   [No title captured]
   [No title captured]
   [No title captured]
NR 45
TC 0
Z9 0
U1 0
U2 8
PU INST NAC PSIQUIATRIA RAMON FUENTE MUNIZ
PI MEXICO CITY
PA CALZ MEXICO-XOCHIMILCO #101, MEXICO CITY 22 DF, MEXICO
SN 0185-3325
J9 SALUD MENT
JI Salud Ment.
PD MAY-JUN
PY 2019
VL 42
IS 3
BP 111
EP 120
DI 10.17711/SM.0185-3325.2019.015
PG 10
WC Psychiatry
WE Social Science Citation Index (SSCI)
SC Psychiatry
GA IV7HC
UT WOS:000484436200003
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Rasmi, Y
   Mehraban, K
   Sadreddini, M
   Zeynalzadeh, J
   Majidinia, M
   Seyyed-Mohammadzad, M
   Babazadeh, H
AF Rasmi, Yousef
   Mehraban, Kamal
   Sadreddini, Masoud
   Zeynalzadeh, Javad
   Majidinia, Maryam
   Seyyed-Mohammadzad, MirHossein
   Babazadeh, Homayoon
TI Lack of significant association between Helicobacter pylori
   infection and homocysteine levels in patients with cardiac syndrome X
SO CARDIOLOGY JOURNAL
LA English
DT Article
DE cardiac syndrome X; Helicobacter pylori; homocysteine
ID ENDOTHELIAL DYSFUNCTION; FLOW
AB Background: Helicobacter pylori (H.pylori) has been implicated in the pathogenesis of several diseases such as cardiac syndrome X (CSX), which includes chest pain, positive exercise stress test and normal angiography. Also, elevation of homocysteine (Hcy) level is associated with CSX, as it can severely disturb vascular endothelial function. We aimed to elucidate whether the infection of H.pylori affect the level of Hcy in CSX.
   Methods: Eighty-eight patients with CSX (32 men, 56 women; mean age: 53.8 +/- 11.9) and 97 healthy controls (36 men, 61 women; mean age: 45.7 +/- 7.3) were enrolled. Plasma samples were tested for the presence of IgG antibody to H.pylori using enzyme linked immunosorbent assay method. Hcy levels were measured enzymatically.
   Results: Plasma Hcy concentration in CSX patients is higher than control group (13.1 +/- 2.6 vs. 11.8 +/- 2.5 mu mol/L; p = 0.002). There was no significant difference between Hcy in H.pylori(+) and H.pylori(-) individuals in CSX group (13.1 +/- 2.7 vs. 12.2 +/- 0.6 mu mol/L; p = 0.554) and between two groups in controls, respectively (12.1 +/- 2.2 vs. 11.4 +/- 2.9 mu mol/L; p = 0.148).
   Conclusions: Although there is Hcy level increase in H.pylori(+) CSX patients and controls comparing to H.pylori(-) subjects, but other factors may affect on Hcy level, too. (Cardiol J 2012; 19, 5: 466-469)
C1 [Rasmi, Yousef] Urmia Univ Med Sci, Ctr Cellular & Mol Res, Orumiyeh, Iran.
   [Rasmi, Yousef; Majidinia, Maryam] Urmia Univ Med Sci, Fac Med, Dept Biochem, Orumiyeh, Iran.
   [Mehraban, Kamal; Sadreddini, Masoud] Urmia Univ Med Sci, Fac Med, Dept Gastroenterol, Orumiyeh, Iran.
   [Zeynalzadeh, Javad] Payame Noor Univ, Dept Biol, Tehran, Iran.
   [Seyyed-Mohammadzad, MirHossein] Urmia Univ Med Sci, Fac Med, Dept Cardiol, Orumiyeh, Iran.
   [Babazadeh, Homayoon] Urmia Univ Med Sci, Fac Med, Dept Microbiol, Orumiyeh, Iran.
C3 Urmia University of Medical Sciences; Urmia University of Medical
   Sciences; Urmia University of Medical Sciences; Payame Noor University;
   Urmia University of Medical Sciences; Urmia University of Medical
   Sciences
RP Rasmi, Y (corresponding author), Urmia Univ Med Sci, Ctr Cellular & Mol Res, Orumiyeh, Iran.
EM rasmiy@umsu.ac.ir
RI majidinia, maryam/V-7187-2019; Babazadeh, Homayoun/E-6461-2018; Rasmi,
   Prof. Yousef/H-1783-2017
OI Rasmi, Prof. Yousef/0000-0003-1506-1909; Majidinia,
   Maryam/0000-0001-9776-5816
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NR 18
TC 5
Z9 6
U1 0
U2 4
PU VIA MEDICA
PI GDANSK
PA UL SWIETOKRZYSKA 73, 80-180 GDANSK, POLAND
SN 1897-5593
EI 1898-018X
J9 CARDIOL J
JI Cardiol. J.
PD SEP
PY 2012
VL 19
IS 5
BP 466
EP 469
DI 10.5603/CJ.2012.0086
PG 4
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 046NO
UT WOS:000311771900005
PM 23042309
OA gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Liang, NC
   Smith, ME
   Moran, TH
AF Liang, N. -C.
   Smith, M. E.
   Moran, T. H.
TI PALATABLE FOOD AVOIDANCE AND ACCEPTANCE LEARNING WITH DIFFERENT
   STRESSORS IN FEMALE RATS
SO NEUROSCIENCE
LA English
DT Article
DE interoceptive stress; restraint stress; food preference learning; HPA
   axis; visceral pathway; binge eating
ID C-FOS EXPRESSION; REPEATED RESTRAINT STRESS; CONDITIONED TASTE-AVERSION;
   CORTICOTROPIN-RELEASING HORMONE; PITUITARY-ADRENOCORTICAL AXIS; AREA
   POSTREMA LESIONS; BODY-WEIGHT; LITHIUM-CHLORIDE; PARAVENTRICULAR
   NUCLEUS; HYPOPHAGIC RESPONSES
AB Stress activates the hypothalamus-pituitary-adrenal (HPA) axis leading to the release of glucocorticoids (GC). Increased activity of the HPA axis and GC exposure has been suggested to facilitate the development of obesity and metabolic syndrome. Nonetheless, different stressors can produce distinct effects on food intake and may support different directions of food learning e.g. avoidance or acceptance. This study examined whether interoceptive (LiCl) and exendin-4) and restraint stress (RS) support similar or distinct food learning. Female rats were exposed to different stressors after their consumption of a palatable food (butter icing). After four palatable food-stress pairings, distinct intakes of the butter icing were observed in rats treated with different stressors. Rats that received butter icing followed by intraperitoneal injections of LiCl (42.3 mg/kg) and exendin-4 (10 mu g/kg) completely avoided the palatable food with subsequent presentations. In contrast, rats experiencing RS paired with the palatable food increased their consumption of butter icing across trials and did so to a greater degree than rats receiving saline injections. These data indicate that interoceptive and psychosocial stressors support conditioned food avoidance and acceptance, respectively. Examination of c-Fos immunoreactivity revealed distinct neural activation by interoceptive and psychosocial stressors that could provide the neural basis underlying opposite direction of food acceptance learning. Published by Elsevier Ltd. on behalf of IBRO.
C1 [Liang, N. -C.; Smith, M. E.; Moran, T. H.] Johns Hopkins Univ, Dept Psychiat & Behav Sci, Sch Med, Baltimore, MD 21205 USA.
C3 Johns Hopkins University
RP Liang, NC (corresponding author), Johns Hopkins Univ, Dept Psychiat & Behav Sci, Sch Med, Ross Bldg Room 621,720 Rutland Ave, Baltimore, MD 21205 USA.
EM nliang2@jhmi.edu
OI Liang, Nu-Chu/0000-0001-5839-5533
FU NIH [DK019302]
FX The authors thank Mr. Ryan Purcell for assisting restraint stress in
   rats and Dr. Kellie Tamashiro for valuable feedback on an earlier
   manuscript. This research is supported by NIH DK019302.
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NR 53
TC 7
Z9 9
U1 0
U2 14
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4522
J9 NEUROSCIENCE
JI Neuroscience
PD APR 3
PY 2013
VL 235
BP 149
EP 158
DI 10.1016/j.neuroscience.2012.12.068
PG 10
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 117SQ
UT WOS:000316973800015
PM 23380501
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Lum, T
   Connolly, M
   Marx, A
   Beidler, J
   Hooshmand, S
   Kern, M
   Liu, CQ
   Hong, MY
AF Lum, Tiffany
   Connolly, Megan
   Marx, Amanda
   Beidler, Joshua
   Hooshmand, Shirin
   Kern, Mark
   Liu, Changqi
   Hong, Mee Young
TI Effects of Fresh Watermelon Consumption on the Acute Satiety Response
   and Cardiometabolic Risk Factors in Overweight and Obese Adults
SO NUTRIENTS
LA English
DT Article
DE watermelon; satiety; oxidative stress; antioxidant; human
ID ORAL GLUCOSE-TOLERANCE; BLOOD-PRESSURE; ANTIOXIDANT CAPACITY; GLYCEMIC
   CONTROL; WAVE REFLECTION; FOOD-INTAKE; SUPPLEMENTATION; FRUCTOSE;
   RAISINS; PLASMA
AB Although some studies have demonstrated the beneficial effects of watermelon supplementation on metabolic diseases, no study has explored the potential mechanism by which watermelon consumption improves body weight management. The objective of this study was to evaluate the effects of fresh watermelon consumption on satiety, postprandial glucose and insulin response, and adiposity and body weight change after 4 weeks of intervention in overweight and obese adults. In a crossover design, 33 overweight or obese subjects consumed watermelon (2 cups) or isocaloric low-fat cookies daily for 4 weeks. Relative to cookies, watermelon elicited more (p < 0.05) robust satiety responses (lower hunger, prospective food consumption and desire to eat and greater fullness). Watermelon consumption significantly decreased body weight, body mass index (BMI), systolic blood pressure and waist-to-hip ratio (p <= 0.05). Cookie consumption significantly increased blood pressure and body fat (p < 0.05). Oxidative stress was lower at four week of watermelon intervention compared to cookie intervention (p = 0.034). Total antioxidant capacity increased with watermelon consumption (p = 0.003) in blood. This study shows that reductions in body weight, body mass index (BMI), and blood pressure can be achieved through daily consumption of watermelon, which also improves some factors associated with overweight and obesity (clinicaltrials.gov, NCT03380221).
C1 [Lum, Tiffany; Connolly, Megan; Marx, Amanda; Beidler, Joshua; Hooshmand, Shirin; Kern, Mark; Liu, Changqi; Hong, Mee Young] San Diego State Univ, Sch Exercise & Nutr Sci, San Diego, CA 92182 USA.
C3 California State University System; San Diego State University
RP Hong, MY (corresponding author), San Diego State Univ, Sch Exercise & Nutr Sci, San Diego, CA 92182 USA.
EM tiffanynlum@gmail.com; megcconnolly@gmail.com; amandamarx27@gmail.com;
   beidler@gmail.com; shooshmand@sdsu.edu; kern@sdsu.edu;
   changqi.liu@sdsu.edu; mhong2@sdsu.edu
RI Lum, Tiffany/W-3459-2019; Liu, Changqi/K-6862-2014
OI Liu, Changqi/0000-0001-6526-5024
FU National Watermelon Promotion Board [NWPB 17-18]
FX This study was funded by the National Watermelon Promotion Board (NWPB
   17-18).
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NR 52
TC 28
Z9 33
U1 2
U2 33
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD MAR 12
PY 2019
VL 11
IS 3
AR 595
DI 10.3390/nu11030595
PG 13
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA HT2CD
UT WOS:000464369900012
PM 30870970
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Hu, YY
   Hou, ZX
   Yi, RK
   Wang, ZM
   Sun, P
   Li, GJ
   Zhao, X
   Wang, Q
AF Hu, Yuanyuan
   Hou, Zuoxu
   Yi, Ruokun
   Wang, Zhongming
   Sun, Peng
   Li, Guijie
   Zhao, Xin
   Wang, Qiang
TI Tartary buckwheat flavonoids ameliorate high fructose-induced insulin
   resistance and oxidative stress associated with the insulin signaling
   and Nrf2/HO-1 pathways in mice
SO FOOD & FUNCTION
LA English
DT Article
ID PROTECT HEPATIC CELLS; METABOLIC SYNDROME; LIVER-INJURY; CORN SYRUP;
   GREEN TEA; QUERCETIN; DIET; EXTRACT; GLUCOSE; NRF2
AB The present study was conducted to explore the effects of a purified tartary buckwheat flavonoid fraction (TBF) on insulin resistance and hepatic oxidative stress in mice fed high fructose in drinking water (20%) for 8 weeks. The results indicated that continuous administration of TBF dose-dependently improved the insulin sensitivity and glucose intolerance in high fructose-fed mice. TBF treatment also reversed the reduced level of insulin action on the phosphorylation of insulin receptor substrate-1 (IRS-1), protein kinase B (Akt) and phosphatidylinositol 3-kinase (PI3K), as well as the translocation of glucose transporter type 4 (GLUT4) in the insulin-resistant liver. Furthermore, TBF was found to exert high antioxidant capacity as it acts as a shield against oxidative stress induced by high fructose by restoring the antioxidant status, and modulating nuclear factor E2 related factor 2 (Nrf2) translocation to the nucleus with subsequently up-regulated antioxidative enzyme protein expression. Histopathological examinations revealed that impaired pancreatic/hepatic tissues were effectively restored in high fructose-fed mice following TBF treatment. Our results show that TBF intake is effective in preventing the conversion of high fructoseinduced insulin resistance and hepatic oxidative stress in mice by improving the insulin signaling molecules and the Nrf2 signal pathway in the liver.
C1 [Hu, Yuanyuan; Yi, Ruokun; Wang, Zhongming; Sun, Peng; Li, Guijie; Zhao, Xin; Wang, Qiang] Chongqing Univ Educ, Chongqing Collaborat Innovat Ctr Funct Food, Chongqing 400067, Peoples R China.
   [Hou, Zuoxu] Fourth Mil Med Univ, Dept Aerosp Med, Xian 710032, Shaanxi, Peoples R China.
C3 Chongqing University of Education; Air Force Medical University
RP Wang, Q (corresponding author), Chongqing Univ Educ, Chongqing Collaborat Innovat Ctr Funct Food, Chongqing 400067, Peoples R China.
EM gogo1443@sina.com
RI Li, Guijie/C-8028-2019; Sun, Peng/KDO-4243-2024; Wang,
   Qiang/AAV-7131-2021; hu, yuan/HTL-4197-2023
OI , Qiang Wang/0000-0001-6281-0699; Hu, Yuanyuan/0000-0001-6788-702X
FU Natural Science Foundation of China [31401559]; Scientific and
   Technological Research Program of Chongqing Municipal Education
   Commission [KJ1714357]; Program for Innovation Team Building at
   Institutions of Higher Education in Chongqing [CXTDX201601040]
FX This study was supported by the grants from the Natural Science
   Foundation of China (No. 31401559), the Scientific and Technological
   Research Program of Chongqing Municipal Education Commission (Grant No.
   KJ1714357), and the Program for Innovation Team Building at Institutions
   of Higher Education in Chongqing (No. CXTDX201601040).
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NR 46
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U1 1
U2 58
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PD AUG 1
PY 2017
VL 8
IS 8
BP 2803
EP 2816
DI 10.1039/c7fo00359e
PG 14
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA FD8IO
UT WOS:000407768600017
PM 28714504
DA 2025-06-11
ER

PT J
AU Gutiérrez-Cuevas, J
   Sandoval-Rodriguez, A
   Meza-Rios, A
   Monroy-Ramírez, HC
   Galicia-Moreno, M
   García-Bañuelos, J
   Santos, A
   Armendariz-Borunda, J
AF Gutierrez-Cuevas, Jorge
   Sandoval-Rodriguez, Ana
   Meza-Rios, Alejandra
   Monroy-Ramirez, Hugo Christian
   Galicia-Moreno, Marina
   Garcia-Banuelos, Jesus
   Santos, Arturo
   Armendariz-Borunda, Juan
TI Molecular Mechanisms of Obesity-Linked Cardiac Dysfunction: An Up-Date
   on Current Knowledge
SO CELLS
LA English
DT Review
DE obesity; cardiovascular diseases; pathophysiology; PPARs; epigenetic
   modifications; gut microbiota dysbiosis; biomarkers; animal models;
   therapeutic treatments
AB Obesity is defined as excessive body fat accumulation, and worldwide obesity has nearly tripled since 1975. Excess of free fatty acids (FFAs) and triglycerides in obese individuals promote ectopic lipid accumulation in the liver, skeletal muscle tissue, and heart, among others, inducing insulin resistance, hypertension, metabolic syndrome, type 2 diabetes (T2D), atherosclerosis, and cardiovascular disease (CVD). These diseases are promoted by visceral white adipocyte tissue (WAT) dysfunction through an increase in pro-inflammatory adipokines, oxidative stress, activation of the renin-angiotensin-aldosterone system (RAAS), and adverse changes in the gut microbiome. In the heart, obesity and T2D induce changes in substrate utilization, tissue metabolism, oxidative stress, and inflammation, leading to myocardial fibrosis and ultimately cardiac dysfunction. Peroxisome proliferator-activated receptors (PPARs) are involved in the regulation of carbohydrate and lipid metabolism, also improve insulin sensitivity, triglyceride levels, inflammation, and oxidative stress. The purpose of this review is to provide an update on the molecular mechanisms involved in obesity-linked CVD pathophysiology, considering pro-inflammatory cytokines, adipokines, and hormones, as well as the role of oxidative stress, inflammation, and PPARs. In addition, cell lines and animal models, biomarkers, gut microbiota dysbiosis, epigenetic modifications, and current therapeutic treatments in CVD associated with obesity are outlined in this paper.
C1 [Gutierrez-Cuevas, Jorge; Sandoval-Rodriguez, Ana; Monroy-Ramirez, Hugo Christian; Galicia-Moreno, Marina; Garcia-Banuelos, Jesus; Armendariz-Borunda, Juan] Univ Guadalajara, Inst Mol Biol Med & Gene Therapy, Dept Mol Biol & Genom, CUCS, Guadalajara 44340, Jalisco, Mexico.
   [Meza-Rios, Alejandra; Santos, Arturo; Armendariz-Borunda, Juan] Tecnol Monterrey, Sch Med & Hlth Sci, Campus Guadalajara, Zapopan 45201, Jalisco, Mexico.
C3 Universidad de Guadalajara; Tecnologico de Monterrey
RP Armendariz-Borunda, J (corresponding author), Univ Guadalajara, Inst Mol Biol Med & Gene Therapy, Dept Mol Biol & Genom, CUCS, Guadalajara 44340, Jalisco, Mexico.; Armendariz-Borunda, J (corresponding author), Tecnol Monterrey, Sch Med & Hlth Sci, Campus Guadalajara, Zapopan 45201, Jalisco, Mexico.
EM gutierrezcj05@gmail.com; anasol44@hotmail.com;
   alejandramezarios@yahoo.com.mx; christian.monroy0981@gmail.com;
   marigamo_11@hotmail.com; bgarcia@cucs.udg.mx; arturo.santos@itesm.mx;
   armdbo@gmail.com
RI Santos, Arturo/GQQ-1431-2022; Sandoval-Rodriguez, Ana/AFA-1796-2022;
   Meza-Rios, Alejandra/Q-6629-2019; Galicia-Moreno, Marina/AAQ-5089-2021;
   Armendáriz-Borunda, Juan/AAU-1471-2021
OI Meza-Rios, Alejandra/0000-0002-1322-1684; Garcia-Banuelos,
   Jesus/0000-0003-3430-9391; Monroy-Ramirez, Hugo
   Christian/0000-0001-8891-5317; Galicia-Moreno,
   Marina/0000-0002-7435-1861; Armendariz-Borunda, Juan/0000-0002-7101-9943
FU Fondo de Desarrollo Cientifico de Jalisco (FODECIJAL) [8149-2019,
   7941-2019]
FX This work has received funding from the Fondo de Desarrollo Cientifico
   de Jalisco (FODECIJAL) project 8149-2019 to J.G.C., and project
   7941-2019 to J.A.B.
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NR 166
TC 68
Z9 70
U1 4
U2 31
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2073-4409
J9 CELLS-BASEL
JI Cells
PD MAR
PY 2021
VL 10
IS 3
AR 629
DI 10.3390/cells10030629
PG 27
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA RD4QB
UT WOS:000633463600001
PM 33809061
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Giris, M
   Dogru-Abbasoglu, S
   Soluk-Tekkesin, M
   Olgaç, V
   Uysal, M
AF Giris, Murat
   Dogru-Abbasoglu, Semra
   Soluk-Tekkesin, Merva
   Olgac, Vakur
   Uysal, Mujdat
TI Effect of betaine treatment on the regression of existing hepatic
   triglyceride accumulation and oxidative stress in rats fed on high
   fructose diet
SO GENERAL PHYSIOLOGY AND BIOPHYSICS
LA English
DT Article
DE Betaine; High fructose diet; Steatosis; Oxidative stress; Liver
ID NONALCOHOLIC FATTY LIVER; METABOLIC SYNDROME; SUPPLEMENTATION;
   MECHANISM; INJURY; ALLEVIATION; FIBROSIS; DAMAGE
AB We investigated whether betaine has any regressive effect on existing high fructose diet (HFrD)-induced insulin resistance, dyslipidemia, inflammation as well as hepatic steatosis and oxidative stress. Rats were fed a HFrD containing 60% fructose for 8 weeks. After 8 weeks, rats were divided into two groups and fed a control diet for an additional 4-week period (regression groups). One of the regression groups received drinking water containing betaine (1%; w/v), having antioxidant and anti-inflammatory actions. HFrD feeding caused insulin resistance, elevated triglyceride (TG) and tumor necrosis factor-alfa (TNF-alpha) levels, alanine aminotransferase (ALT) and aspartate transaminase (AST) activities in serum. This diet increased hepatic TG, thiobarbituric acid reactive substances (TBARS) and diene conjugate (DC) levels, decreased superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities. Marked macro-vesicular steatosis were detected. Serum TNF-alpha and ALT, hepatic TG, TBARS and DC levels and steatosis scores decreased in regression period of HFrD-fed rats. Additionally, serum TNF-alpha, hepatic TG, TBARS and DC levels significantly lower in betaine-treated regressed rats than non-treated regressed group. Our results indicate that betaine treatment may accelerate regression of HFrD-induced hepatic TG accumulation and oxidative stress in rats.
C1 [Giris, Murat] Istanbul Univ, Aziz Sancar Expt & Med Res Inst, Istanbul, Turkey.
   [Dogru-Abbasoglu, Semra; Uysal, Mujdat] Istanbul Univ, Istanbul Fac Med, Dept Biochem, TR-34093 Istanbul, Turkey.
   [Soluk-Tekkesin, Merva; Olgac, Vakur] Istanbul Univ, Oncol Inst, Dept Pathol, Istanbul, Turkey.
C3 Istanbul University; Istanbul University; Istanbul University
RP Dogru-Abbasoglu, S (corresponding author), Istanbul Univ, Istanbul Fac Med, Dept Biochem, TR-34093 Istanbul, Turkey.
EM sdabbasoglu@yahoo.com
RI Soluk-Tekkesin, Merva/AAA-2126-2020; Giriş, Murat/JHT-8513-2023;
   Abbasoglu, Semra/AAD-9014-2020
OI Soluk Tekkesin, Merva/0000-0002-7178-3335
FU Istanbul University Scientific Research Projects [6727, BEK-2017-24919]
FX The present work was supported by the Istanbul University Scientific
   Research Projects (Project No: 6727 and BEK-2017-24919).
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NR 35
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Z9 12
U1 1
U2 6
PU GENERAL PHYSIOL AND BIOPHYSICS
PI BRATISLAVA
PA INST OF MOLEC PHYSIOL GENETICS SLOVAK ACAD OF SCI VLARSKA 5, 83334
   BRATISLAVA, SLOVAKIA
SN 0231-5882
EI 1338-4325
J9 GEN PHYSIOL BIOPHYS
JI Gen. Physiol. Biophys.
PD SEP
PY 2018
VL 37
IS 5
BP 563
EP 570
DI 10.4149/gpb_2018005x
PG 8
WC Biochemistry & Molecular Biology; Biophysics; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Physiology
GA GX9CT
UT WOS:000448096800007
PM 30047921
OA gold
DA 2025-06-11
ER

PT J
AU Martins, TD
   Ramos, RC
   Possidonio, G
   Bosculo, MRM
   Oliveira, PL
   Costa, LR
   Zamboni, VAG
   Marques, MG
   de Almeida, BFM
AF Martins, Tainara de Oliveira
   Ramos, Rebecca Capera
   Possidonio, Geovana
   Bosculo, Maria Rachel Melo
   Oliveira, Paula Lima
   Costa, Leticia Ramos
   Zamboni, Vinicius Aquiles Gomes
   Marques, Marcel Gambin
   de Almeida, Breno Fernando Martins
TI Feline obesity causes hematological and biochemical changes and
   oxidative stress - a pilot study
SO VETERINARY RESEARCH COMMUNICATIONS
LA English
DT Article
DE Complete blood count (CBC); Reactive oxygen species; Antioxidants; Cats
ID CELL DISTRIBUTION WIDTH; RISK-FACTORS; LIPOPROTEIN CONCENTRATIONS;
   LIPID-PEROXIDATION; NITRIC-OXIDE; INSULIN-RESISTANCE; METABOLIC
   SYNDROME; DIABETES-MELLITUS; COMPANION ANIMALS; BODY CONDITION
AB Obesity, an extremely important factor in feline clinical practice, is estimated to affect up to one third of the feline population. Moreover, it can trigger chronic inflammation, which could predispose to oxidative stress by increasing reactive oxygen species, thereby generating potentially irreversible cellular damage. This study analyzed hematological, biochemical and oxidative stress profiles at various degrees of feline obesity. Forty-five cats were selected and divided into three groups: control (n = 17), overweight (n = 13) and obese (n = 15), after clinical and laboratory evaluation and body condition score. Biochemical and oxidative stress analyses were performed using a photocolorimeter and hematological analyses were performed in a veterinary cell counter. Obese cats showed increased mean corpuscular volume (MCV), red cell distribution width (RDW), HDL cholesterol and triglycerides and decreased activity of gamma-glutamyl transferase (GGT) than control cats, although within the reference ranges for the species. As for oxidative stress, obese cats showed higher total antioxidant capacity (TAC), by the inhibition of 2,2'-Azino-Bis-3-Ethylbenzthiazoline-6-Sulfonic Acid (ABTS), inhibition of ABTS associated with horseradish peroxidase (ABTS + HRP), cupric ion reducing antioxidant capacity (CUPRAC) and ferric reducing antioxidant power (FRAP) methods, while overweight cats had a higher TAC-ABTS + HRP and TAC-FRAP than control cats. We conclude that the conditions of natural obesity and overweight in the feline species alter its hematological, biochemical and oxidative stress parameters.
C1 [Martins, Tainara de Oliveira; Ramos, Rebecca Capera; Possidonio, Geovana; Bosculo, Maria Rachel Melo; Costa, Leticia Ramos; Zamboni, Vinicius Aquiles Gomes; Marques, Marcel Gambin; de Almeida, Breno Fernando Martins] Roque Quagliato Vet Hosp, Univ Ctr Integrated Fac Ourinhos Unifio, Rodovia BR 153,km 338, BR-19909100 Ourinhos, SP, Brazil.
   [Oliveira, Paula Lima; de Almeida, Breno Fernando Martins] Sao Paulo State Univ FMVA Unesp, Fac Vet Med Aracatuba, Aracatuba, SP, Brazil.
RP de Almeida, BFM (corresponding author), Roque Quagliato Vet Hosp, Univ Ctr Integrated Fac Ourinhos Unifio, Rodovia BR 153,km 338, BR-19909100 Ourinhos, SP, Brazil.; de Almeida, BFM (corresponding author), Sao Paulo State Univ FMVA Unesp, Fac Vet Med Aracatuba, Aracatuba, SP, Brazil.
EM breno.fernando@unifio.edu.br
RI Almeida, Breno/C-5156-2013
OI Almeida, Breno/0000-0002-6379-6734; Aquiles Gomes Zamboni,
   Vinicius/0000-0002-8923-1918
FU Sao Paulo Research Foundation (FAPESP) [2018/18220-0]; CAPES [AUXPE
   0255/2021, 88881.638964/2021-01]; FAPESP [2018/19683-4]
FX To Sao Paulo Research Foundation (FAPESP, Proc. 2018/18220-0) and CAPES
   (AUXPE 0255/2021, n. 88881.638964/2021-01) for funding this research,
   and FAPESP for the scholarship granted (2018/19683-4).
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NR 94
TC 9
Z9 9
U1 1
U2 19
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0165-7380
EI 1573-7446
J9 VET RES COMMUN
JI Vet. Res. Commun.
PD JAN
PY 2023
VL 47
IS 1
BP 167
EP 177
DI 10.1007/s11259-022-09940-5
EA JUL 2022
PG 11
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA 8J3YB
UT WOS:000819693100001
PM 35778642
DA 2025-06-11
ER

PT J
AU Dallio, M
   Sangineto, M
   Romeo, M
   Villani, R
   Romano, AD
   Loguercio, C
   Serviddio, G
   Federico, A
AF Dallio, Marcello
   Sangineto, Moris
   Romeo, Mario
   Villani, Rosanna
   Romano, Antonino Davide
   Loguercio, Carmelina
   Serviddio, Gaetano
   Federico, Alessandro
TI Immunity as Cornerstone of Non-Alcoholic Fatty Liver Disease: The
   Contribution of Oxidative Stress in the Disease Progression
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE non-alcoholic fatty liver disease; trained immunity; oxidative stress;
   hepatocellular carcinoma
ID REGULATORY T-CELLS; HEPATIC STELLATE CELLS; NF-KAPPA-B;
   ENDOPLASMIC-RETICULUM STRESS; NATURAL-KILLER-CELLS;
   HEPATOCELLULAR-CARCINOMA; INSULIN-RESISTANCE; DENDRITIC CELLS;
   MITOCHONDRIAL DYSFUNCTION; IN-VITRO
AB Non-alcoholic fatty liver disease (NAFLD) is considered the hepatic manifestation of metabolic syndrome and has become the major cause of chronic liver disease, especially in western countries. NAFLD encompasses a wide spectrum of hepatic histological alterations, from simple steatosis to steatohepatitis and cirrhosis with a potential development of hepatocellular carcinoma. Non-alcoholic steatohepatitis (NASH) is characterized by lobular inflammation and fibrosis. Several studies reported that insulin resistance, redox unbalance, inflammation, and lipid metabolism dysregulation are involved in NAFLD progression. However, the mechanisms beyond the evolution of simple steatosis to NASH are not clearly understood yet. Recent findings suggest that different oxidized products, such as lipids, cholesterol, aldehydes and other macromolecules could drive the inflammation onset. On the other hand, new evidence indicates innate and adaptive immunity activation as the driving force in establishing liver inflammation and fibrosis. In this review, we discuss how immunity, triggered by oxidative products and promoting in turn oxidative stress in a vicious cycle, fuels NAFLD progression. Furthermore, we explored the emerging importance of immune cell metabolism in determining inflammation, describing the potential application of trained immune discoveries in the NASH pathological context.
C1 [Dallio, Marcello; Romeo, Mario; Loguercio, Carmelina; Federico, Alessandro] Univ Campania Luigi Vanvitelli, Dept Precis Med, Hepatogastroenterol Div, Via S Pansini 5, I-80131 Naples, Italy.
   [Sangineto, Moris; Villani, Rosanna; Romano, Antonino Davide; Serviddio, Gaetano] Univ Foggia, Dept Med & Surg Sci, CURE Univ Ctr Liver Dis Res & Treatment, Liver Unit, I-71121 Foggia, Italy.
C3 Universita della Campania Vanvitelli; University of Foggia
RP Sangineto, M (corresponding author), Univ Foggia, Dept Med & Surg Sci, CURE Univ Ctr Liver Dis Res & Treatment, Liver Unit, I-71121 Foggia, Italy.
EM marcello.dallio@unicampania.it; moris.sangineto@unifg.it;
   mario.romeo@unicampania.it; rosanna.villani@unifg.it;
   antoninodavide.romano@unifg.it; carmelina.loguercio@unicampania.it;
   gaetano.serviddio@unifg.it; alessandro.federico@unicampania.it
RI Dallio, Marcello/ABG-7693-2020; Romano, Antonino Davide/ABB-3039-2021;
   Villani, Rosanna/K-5753-2018; Sangineto, Moris/AAJ-8889-2021; serviddio,
   gaetano/C-7629-2011
OI Sangineto, Moris/0000-0002-0936-8843; Romeo, Mario/0000-0002-2970-9019;
   DALLIO, MARCELLO/0000-0003-4153-815X; Villani,
   Rosanna/0000-0001-9875-019X; serviddio, gaetano/0000-0002-6424-7841
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NR 234
TC 46
Z9 49
U1 4
U2 26
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD JAN
PY 2021
VL 22
IS 1
AR 436
DI 10.3390/ijms22010436
PG 23
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA PP7KC
UT WOS:000606036100001
PM 33406763
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Liu, XX
   Sun, CB
   Yang, TT
   Li, D
   Li, CY
   Tian, YJ
   Guo, M
   Cao, Y
   Zhou, SS
AF Liu, Xing-Xing
   Sun, Chang-Bin
   Yang, Ting-Tong
   Li, Da
   Li, Chun-Yan
   Tian, Yan-Jie
   Guo, Ming
   Cao, Yu
   Zhou, Shi-Sheng
TI Decreased Skin-Mediated Detoxification Contributes to Oxidative Stress
   and Insulin Resistance
SO EXPERIMENTAL DIABETES RESEARCH
LA English
DT Article
ID HUMAN ECCRINE SWEAT; METABOLIC SYNDROME; SENSITIVITY; PREVALENCE;
   PHYSIOLOGY; OVERLOAD; CHILDREN; BLOOD; SAUNA
AB The skin, the body's largest organ, plays an important role in the biotransformation/ detoxification and elimination of xenobiotics and endogenous toxic substances, but its role in oxidative stress and insulin resistance is unclear. We investigated the relationship between skin detoxification and oxidative stress/insulin resistance by examining burn-induced changes in nicotinamide degradation. Rats were divided into four groups: sham-operated, sham-nicotinamide, burn, and burn-nicotinamide. Rats received an intraperitoneal glucose injection (2 g/kg) with (sham-nicotinamide and burn-nicotinamide groups) or without (sham-operated and burn groups) coadministration of nicotinamide (100 mg/kg). The results showed that the mRNA of all detoxification-related enzymes tested was detected in sham-operated skin but not in burned skin. The clearance of nicotinamide and N-1-methylnicotinamide in burned rats was significantly decreased compared with that in sham-operated rats. After glucose loading, burn group showed significantly higher plasma insulin levels with a lower muscle glycogen level than that of sham-operated and sham-nicotinamide groups, although there were no significant differences in blood glucose levels over time between groups. More profound changes in plasma H2O2 and insulin levels were observed in burn-nicotinamide group. It may be concluded that decreased skin detoxification may increase the risk for oxidative stress and insulin resistance.
C1 [Liu, Xing-Xing; Li, Chun-Yan; Tian, Yan-Jie; Zhou, Shi-Sheng] Dalian Univ, Dept Physiol, Coll Med, Dalian 116622, Peoples R China.
   [Sun, Chang-Bin] Dalian Univ, Dept Histol & Embryol, Coll Med, Dalian 116622, Peoples R China.
   [Yang, Ting-Tong] Xinxiang Med Coll, Dept Pathol, Xinxiang 453003, Peoples R China.
   [Li, Da; Cao, Yu] China Med Univ, Dept Physiol, Shenyang 110001, Peoples R China.
   [Guo, Ming] Dalian Univ, Coll Environm & Chem Engn, Dalian 116622, Peoples R China.
C3 Dalian University; Dalian University; Xinxiang Medical University; China
   Medical University; Dalian University
RP Zhou, SS (corresponding author), Dalian Univ, Dept Physiol, Coll Med, Dalian 116622, Peoples R China.
EM zhouss@ymail.com
RI Li, Chunyan/F-5309-2016
OI Zhou, Shi-Sheng/0000-0001-5156-3610
FU National Natural Science Foundation of China [31140036]; Foundation of
   Key Laboratory of Education Department of Liaoning Province [2009S005]
FX This research was supported by the National Natural Science Foundation
   of China (no. 31140036) and the Foundation of Key Laboratory of
   Education Department of Liaoning Province (no. 2009S005).
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NR 37
TC 1
Z9 1
U1 1
U2 12
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1687-5214
EI 1687-5303
J9 EXP DIABETES RES
JI Exp. Diabetes Res.
PY 2012
AR 128694
DI 10.1155/2012/128694
PG 9
WC Endocrinology & Metabolism; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Research & Experimental Medicine
GA 997LG
UT WOS:000308166400001
PM 22899900
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

EF﻿FN Clarivate Analytics Web of Science
VR 1.0
PT J
AU Ibitoye, OB
   Olofinsan, KA
   Terali, K
   Ghali, UM
   Ajiboye, TO
AF Ibitoye, O. B.
   Olofinsan, K. A.
   Terali, K.
   Ghali, U. M.
   Ajiboye, T. O.
TI Bioactivity-guided isolation of antidiabetic principles from the
   methanolic leaf extract of Bryophyllum pinnatum
SO JOURNAL OF FOOD BIOCHEMISTRY
LA English
DT Article
DE diabetes; dyslipidaemia; kaempferol; oxidative stress; quercetin
ID INDUCED METABOLIC SYNDROME; CUMMINSII STAPF DIELS; INSULIN-RESISTANCE;
   OXIDATIVE STRESS; LEAVES; QUERCETIN; HYPERGLYCEMIA; INFLAMMATION;
   DYSLIPIDEMIA; RESVERATROL
AB The antidiabetic principles from methanolic leaf extract of Bryophyllum pinnatum were isolated. The leaf extract was fractionated on silica gel using column chromatography and identified using nuclear magnetic resonance (NMR) spectrometry. The ethylacetate fraction of the partitioned methanolic extract of B. pinnatum lowered blood glucose of alloxan-induced diabetic rats and inhibited -amylase and -glucosidase with IC50 137.89 and 110.15 mu g/mL, respectively. In addition to lowering blood glucose, fractions A and B inhibited -amylase with IC50 57.43 and 43.84 mu g/mL and -glucosidase with IC50 11.15 and 25.79 mu g/mL, respectively. H-1 and C-13 NMR showed that fractions A and B are quercetin and kaempeferol, respectively. Molecular docking revealed that kaempferol and quercetin interacted with amino acid residues that bind/hydrolyze substrate molecules These compounds reversed altered lipid profile and oxidative stress biomarkers. Our findings showed that kaempferol and quercetin are responsible for the antidiabetic activity of B. pinnatum.
   Practical application Bryophyllum pinnatum is an edible vegetable plant in some parts of Nigeria, and its consumption could improve diabetic condition and lower postprandial glucose. Furthermore, extract of the leaves could be developed into food supplements for managing diabetes and its associated complications including dyslipidaemia and oxidative stress.
C1 [Ibitoye, O. B.] Al Hikmah Univ, Dept Biol Sci, Ilorin, Nigeria.
   [Olofinsan, K. A.] Nile Univ Nigeria, Fac Nat & Appl Sci, Dept Biol Sci, Abuja, Nigeria.
   [Terali, K.; Ghali, U. M.] Near East Univ, Dept Med Biochem, Fac Med, Nicosia, Cyprus.
   [Ajiboye, T. O.] Nile Univ Nigeria, Dept Med Biochem, Coll Hlth Sci, Antioxidants Redox Biol & Toxicol Res Grp, Abuja, Nigeria.
C3 Near East University
RP Ajiboye, TO (corresponding author), Nile Univ Nigeria, Dept Med Biochem, Coll Hlth Sci, Antioxidants Redox Biol & Toxicol Res Grp, Abuja, Nigeria.
EM ajiboyeyong@yahoo.com
RI olofinsan, Kolawole/AAM-8402-2020; Ajiboye, Taofeek/H-5383-2011; GHALI,
   UMAR/ABI-5679-2020; Terali, Kerem/Q-3270-2016
OI GHALI, UMAR MUHAMMAD/0000-0002-3500-8075; Terali,
   Kerem/0000-0002-9964-6383; olofinsan, kolawole/0000-0002-2987-0996
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NR 67
TC 20
Z9 22
U1 0
U2 9
PU WILEY-HINDAWI
PI LONDON
PA ADAM HOUSE, 3RD FL, 1 FITZROY SQ, LONDON, WIT 5HE, ENGLAND
SN 0145-8884
EI 1745-4514
J9 J FOOD BIOCHEM
JI J. Food Biochem.
PD OCT
PY 2018
VL 42
IS 5
AR e12627
DI 10.1111/jfbc.12627
PG 11
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA GY0CQ
UT WOS:000448178900069
OA gold
DA 2025-06-11
ER

PT J
AU He, Z
   Lv, F
   Ding, YF
   Huang, HG
   Liu, L
   Zhu, CY
   Lei, YY
   Zhang, L
   Si, C
   Wang, H
AF He, Zheng
   Lv, Feng
   Ding, Yufeng
   Huang, Hegui
   Liu, Lian
   Zhu, Chunyan
   Lei, Youyin
   Zhang, Li
   Si, Cai
   Wang, Hui
TI High-fat diet and chronic stress aggravate adrenal function abnormality
   induced by prenatal caffeine exposure in male offspring rats
SO SCIENTIFIC REPORTS
LA English
DT Article
ID METABOLIC SYNDROME; INSULIN-RESISTANCE; OXIDATIVE STRESS; MILD STRESS;
   AXIS; CORTISOL; SUSCEPTIBILITY; EXPRESSION; RECEPTOR; LIVER
AB We previously demonstrated thatprenatal caffeine exposure (PCE) suppressed fetal adrenal steroidogenesis and resulted in developmental programming changes in offspring rats. However, whether these changes play a role in adrenal corticosterone synthesis under high-fat diet (HFD) and unpredictable chronic stress (UCS) remains unknown. In present study, rat model was established by PCE (120 mg/kg.d), and male offspring were provided normal diet or HFD after weaning. At postnatal week 21, several rats fed HFD were exposed to UCS for 3 weeks and sacrificed. The results showed that compared with the corresponding control group, the serum corticosterone levels and adrenal steroid synthetase expression of the PCE offspring without UCS were reduced. Moreover, the glucocorticoid (GC)-activation system was inhibited, and insulin-like growth factor 1 (IGF1) signaling pathway expression was increased. With UCS exposure in the PCE offspring, serum corticosterone levels and adrenal steroid synthetase expression were increased, the activity of GC-activation system was enhanced, and adrenal IGF1 signaling pathway expression was decreased. Based on these findings, PCE induced adrenal hypersensitivity in adult male offspring rats, as shown by the reduced corticosterone levels under HFD conditions but significantly enhanced corticosterone levels with UCS, in which GC-IGF1 axis programming alteration may play an important role.
C1 [He, Zheng; Lv, Feng; Huang, Hegui; Liu, Lian; Zhu, Chunyan; Lei, Youyin; Zhang, Li; Si, Cai; Wang, Hui] Wuhan Univ, Dept Pharmacol, Basic Med Sch, Wuhan 430071, Hubei, Peoples R China.
   [Wang, Hui] Hubei Prov Key Lab Dev Originated Dis, Wuhan 430071, Hubei, Peoples R China.
   [He, Zheng; Ding, Yufeng] Huazhong Univ Sci & Technol, Dept Pharm, Tongji Hosp, Tongji Med Coll, Wuhan 430030, Hubei, Peoples R China.
C3 Wuhan University; Huazhong University of Science & Technology
RP Wang, H (corresponding author), Wuhan Univ, Dept Pharmacol, Basic Med Sch, Wuhan 430071, Hubei, Peoples R China.; Wang, H (corresponding author), Hubei Prov Key Lab Dev Originated Dis, Wuhan 430071, Hubei, Peoples R China.
EM wanghui19@whu.edu.cn
RI Lv, Feng/KWT-4706-2024; Ding, Yu-Feng/GQH-8913-2022
OI Huang, Hegui/0000-0002-0824-9957
FU National Natural Science Foundation of China [81220108026, 81430089,
   81673524]; National Key Research and Development Program of China
   [2017YFC1001300]; Hubei Province Health and Family Planning Scientific
   Research Project [WJ2017C0003]
FX This work was supported by grants from the National Natural Science
   Foundation of China (Nos 81220108026, 81430089, 81673524), the National
   Key Research and Development Program of China (2017YFC1001300), and
   Hubei Province Health and Family Planning Scientific Research Project
   (No. WJ2017C0003).
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NR 52
TC 19
Z9 20
U1 0
U2 5
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD NOV 1
PY 2017
VL 7
AR 14825
DI 10.1038/s41598-017-14881-0
PG 9
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA FL4XB
UT WOS:000414233700045
PM 29093513
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Nguyen, MT
   Csermely, P
   Söti, C
AF Nguyen, M. T.
   Csermely, P.
   Soeti, C.
TI Hsp90 chaperones PPARγ and regulates differentiation and survival of
   3T3-L1 adipocytes
SO CELL DEATH AND DIFFERENTIATION
LA English
DT Article
DE adipogenesis; diabetes; obesity; proteostasis; stress
ID ACTIVATED RECEPTOR-GAMMA; HEAT-SHOCK-PROTEIN; INSULIN-RESISTANCE;
   HEAT-SHOCK-PROTEIN-90 HSP90; GLUCOCORTICOID-RECEPTOR; DNA-BINDING;
   STRESS; FAT; BETA; ADIPOGENESIS
AB Adipose tissue dysregulation has a major role in various human diseases. The peroxisome proliferator-activated receptor-gamma (PPAR gamma) is a key regulator of adipocyte differentiation and function, as well as a target of insulin-sensitizing drugs. The Hsp90 chaperone stabilizes a diverse set of signaling 'client' proteins, thereby regulates various biological processes. Here we report a novel role for Hsp90 in controlling PPAR gamma stability and cellular differentiation. Specifically, we show that the Hsp90 inhibitors geldanamycin and novobiocin efficiently impede the differentiation of murine 3T3-L1 preadipocytes. Geldanamycin at higher concentrations also inhibits the survival of both developing and mature adipocytes, respectively. Further, Hsp90 inhibition disrupts an Hsp90-PPAR gamma complex, leads to the destabilization and proteasomal degradation of PPAR gamma, and inhibits the expression of PPAR gamma target genes, identifying PPAR gamma as an Hsp90 client. A similar destabilization of PPAR gamma and a halt of adipogenesis also occur in response to protein denaturing stresses caused by a single transient heat-shock or proteasome inhibition. Recovery from stress restores PPAR gamma stability and adipocyte differentiation. Thus, our findings reveal Hsp90 as a critical stress-responsive regulator of adipocyte biology and offer a potential therapeutic target in obesity and the metabolic syndrome.
C1 [Nguyen, M. T.; Csermely, P.; Soeti, C.] Semmelweis Univ, Dept Med Chem, H-1444 Budapest, Hungary.
C3 Semmelweis University
RP Söti, C (corresponding author), Semmelweis Univ, Dept Med Chem, POB 260, H-1444 Budapest, Hungary.
EM soti.csaba@med.semmelweis-univ.hu
RI nguyen, Minh Tu/HPE-8502-2023; Csermely, Peter/J-2067-2017; Sőti,
   Csaba/O-6070-2017
OI Soti, Csaba/0000-0002-4057-7678; Csermely, Peter/0000-0001-9234-0659
FU EU [FP6-518230, TAMOP-4.2.2/B-10/1-2010-0013]; Hungarian Science
   Foundation, Norway [NNF-78794]; Hungarian Science Foundation [NNF-78794,
   OTKA K69105, OTKA-K83314]
FX We thank Livius Wunderlich and Peter Szelenyi for reagents, Zsolt Ronai
   for help in qPCR experiments and Beatrix Gilanyi for technical help. We
   are grateful to members of the Soti Group, and the Editor and anonymous
   reviewers of this manuscript for helpful comments and suggestions. This
   work was supported by grants from the EU (FP6-518230,
   TAMOP-4.2.2/B-10/1-2010-0013), a joint grant of the Hungarian Science
   Foundation and Norway Grants (NNF-78794), the Hungarian Science
   Foundation (OTKA K69105 and OTKA-K83314). During the completion of this
   study, C.S. was a Bolyai Research Scholar of the Hungarian Academy of
   Sciences.
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NR 58
TC 57
Z9 62
U1 2
U2 25
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1350-9047
EI 1476-5403
J9 CELL DEATH DIFFER
JI Cell Death Differ.
PD DEC
PY 2013
VL 20
IS 12
BP 1654
EP 1663
DI 10.1038/cdd.2013.129
PG 10
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA 252MW
UT WOS:000327010600009
PM 24096869
OA Green Published
DA 2025-06-11
ER

PT J
AU Devries, MC
   Hamadeh, MJ
   Glover, AW
   Raha, S
   Samjoo, IA
   Tarnopolsky, MA
AF Devries, Michaela C.
   Hamadeh, Mazen J.
   Glover, Alexander W.
   Raha, Sandeep
   Samjoo, Imtiaz A.
   Tarnopolsky, Mark A.
TI Endurance training without weight loss lowers systemic, but not muscle,
   oxidative stress with no effect on inflammation in lean and obese women
SO FREE RADICAL BIOLOGY AND MEDICINE
LA English
DT Article
DE obesity; endurance training; reactive oxygen species; antioxidant
   enzymes; inflammatory markers
ID NECROSIS-FACTOR-ALPHA; C-REACTIVE PROTEIN; DECREASED CIRCULATING LEVELS;
   FATTY-ACID OXIDATION; SERUM LEPTIN LEVELS; INSULIN-RESISTANCE;
   LIPID-PEROXIDATION; SKELETAL-MUSCLE; ADIPOSE-TISSUE; METABOLIC SYNDROME
AB Obesity is associated with oxidative stress. Endurance training (ET) in healthy individuals increases antioxidant enzyme activity and decreases oxidative stress, whereas its effects on oxidative status in obese humans have yet to be determined. We investigated the effects of obesity and ET on markers of oxidative stress, antioxidant defense, and inflammation. Obese (n=12) and lean (n=12) women underwent 12 weeks of ET with blood, 24-h urine, and muscle biopsies collected prior to and following training for determination of oxidative stress (urinary 8-hydroxy-2-deoxyguanosine and 8-isoprostanes, muscle protein carbonyls, and 4-hydroxynonenal), antioxidant enzyme protein content (muscle CuZnSOD, MnSOD, and catalase), and inflammation (C-reactive protein, leptin, adiponectin, interleukin-6). Obese women had elevated urinary 8-hydroxy-2-deoxyguanosine (P=0.03), muscle protein carbonyls (P=0.03), and 4-hydroxynonenal (P < 0.001); serum C-reactive protein (P=0.01); and plasma leptin (P=0.0001) and interleukin-6 (P=0.03). ET decreased urinary 8-hydroxy-2-deoxyguanosine (P=0.006) and 8-isoprostanes (P=0.02) in all subjects and CuZnSOD protein content (P=0.04) in obese women, in the absence of changes in body weight or composition. ET without weight loss decreases systemic oxidative stress, but not markers of inflammation, in obese women. (c) 2008 Elsevier Inc. All rights reserved.
C1 [Devries, Michaela C.; Hamadeh, Mazen J.; Glover, Alexander W.; Raha, Sandeep; Samjoo, Imtiaz A.; Tarnopolsky, Mark A.] McMaster Univ, Dept Pediat, Med Ctr, Hamilton, ON, Canada.
   [Devries, Michaela C.; Hamadeh, Mazen J.; Glover, Alexander W.; Raha, Sandeep; Samjoo, Imtiaz A.; Tarnopolsky, Mark A.] McMaster Univ, Dept Med, Med Ctr, Hamilton, ON, Canada.
   [Hamadeh, Mazen J.] York Univ, Sch Kinesiol & Hlth Sci, Toronto, ON, Canada.
C3 McMaster University; McMaster University; York University - Canada
RP Tarnopolsky, MA (corresponding author), McMaster Univ, Dept Pediat, Med Ctr, Room 2H26,1200 Main St W, Hamilton, ON, Canada.
EM tarnopol@mcmaster.ca
RI Devries, Michaela/AGF-6403-2022; Raha, Sandeep/AAF-3655-2020
OI Hamadeh, Mazen/0000-0002-3511-4345; Raha, Sandeep/0000-0001-7307-3292
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NR 77
TC 87
Z9 93
U1 0
U2 12
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0891-5849
EI 1873-4596
J9 FREE RADICAL BIO MED
JI Free Radic. Biol. Med.
PD AUG 15
PY 2008
VL 45
IS 4
BP 503
EP 511
DI 10.1016/j.freeradbiomed.2008.04.039
PG 9
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 339ZB
UT WOS:000258614700016
PM 18502211
DA 2025-06-11
ER

PT J
AU Powell, DR
   Gay, JP
   Wilganowski, N
   Doree, D
   Savelieva, KV
   Lanthorn, TH
   Read, R
   Vogel, P
   Hansen, GM
   Brommage, R
   Ding, ZM
   Desai, U
   Zambrowicz, B
AF Powell, David R.
   Gay, Jason P.
   Wilganowski, Nathaniel
   Doree, Deon
   Savelieva, Katerina V.
   Lanthorn, Thomas H.
   Read, Robert
   Vogel, Peter
   Hansen, Gwenn M.
   Brommage, Robert
   Ding, Zhi-Ming
   Desai, Urvi
   Zambrowicz, Brian
TI Diacylglycerol lipase a knockout mice demonstrate metabolic and
   behavioral phenotypes similar to those of cannabinoid receptor 1
   knockout mice
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Article
DE mouse knockout models; diacylglycerol lipase gene; cannabinoid receptor
   1 gene; obesity; endocannabinoids; 2-arachidonoylglycerol; anxiety;
   depression
ID CARDIOMETABOLIC RISK-FACTORS; CB1 RECEPTOR; ENDOCANNABINOID SYSTEM;
   INVERSE AGONIST; GLYCEMIC CONTROL; WEIGHT-LOSS; OBESITY; ANANDAMIDE;
   RIMONABANT; INSULIN
AB After creating >4,650 knockouts (KOs) of independent mouse genes, we screened them by high-throughput phenotyping and found that cannabinoid receptor 1 (Cnr1) KO mice had the same lean phenotype published by others. We asked if our KOs of DAG lipase alpha or beta (Dagla or Daglb), which catalyze biosynthesis of the endocannabinoid (EC) 2-arachidonoylglycerol (2-AG), or Napepld, which catalyzes biosynthesis of the EC anandamide, shared the lean phenotype of Cnr1 KO mice. We found that Dagla KO mice, but not Daglb or Napepld KO mice, were among the leanest of 3651 chow-fed KO lines screened. In confirmatory studies, chow- or high fat diet fed Dagla and Cnr1 KO mice were leaner than wild-type (WT) littermates; when data from multiple cohorts of adult mice were combined, body fat was 47 and 45% lower in Dagla and Cnr1 KO mice, respectively, relative to WT values. By contrast, neither Daglb nor Napepld KO mice were lean. Weanling Dagla KO mice ate less than WT mice and had body weight (BW) similar to pair-fed WT mice, and adult Dagla KO mice had normal activity and VO2 levels, similar to Cnr1 KO mice. Our Dagla and Cnr1 KO mice also had low fasting insulin, triglyceride, and total cholesterol levels, and after glucose challenge had normal glucose but very low insulin levels. Dagla and Cnr1 KO mice also showed similar responses to a battery of behavioral tests. These data suggest: (1) the lean phenotype of young Dagla and Cnr1 KO mice is mainly due to hypophagia; (2) in pathways where ECs signal through Cnr1 to regulate food intake and other metabolic and behavioral phenotypes observed in Cnr1 KO mice, Dagla alone provides the 2-AG that serves as the EC signal; and (3) small molecule Dagla inhibitors with a pharmacokinetic profile similar to that of Cnr1 inverse agonists are likely to mirror the ability of these Cnr1 inverse agonists to lower BW and improve glycemic control in obese patients with type 2 diabetes, but may also induce undesirable neuropsychiatric side-effects.
C1 [Powell, David R.; Gay, Jason P.; Wilganowski, Nathaniel; Doree, Deon; Savelieva, Katerina V.; Lanthorn, Thomas H.; Read, Robert; Vogel, Peter; Hansen, Gwenn M.; Brommage, Robert; Ding, Zhi-Ming; Desai, Urvi; Zambrowicz, Brian] Lexicon Pharmaceut Inc, 8800 Technol Forest Pl, The Woodlands, TX 77381 USA.
C3 Lexicon Pharmaceuticals
RP Powell, DR (corresponding author), Lexicon Pharmaceut Inc, 8800 Technol Forest Pl, The Woodlands, TX 77381 USA.
EM dpowell@lexpharma.com
RI Brommage, Robert/J-5670-2019; Vogel, Peter/N-2490-2018
OI Hansen, Gwenn/0000-0003-2504-5849
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NR 63
TC 45
Z9 49
U1 0
U2 8
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD JUN 2
PY 2015
VL 6
AR 86
DI 10.3389/fendo.2015.00086
PG 13
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA DP4PE
UT WOS:000378477100001
PM 26082754
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Okuno, Y
   Fukuhara, A
   Hashimoto, E
   Kobayashi, H
   Kobayashi, S
   Otsuki, M
   Shimomura, I
AF Okuno, Yosuke
   Fukuhara, Atsunori
   Hashimoto, Erika
   Kobayashi, Hironori
   Kobayashi, Sachiko
   Otsuki, Michio
   Shimomura, Iichiro
TI Oxidative Stress Inhibits Healthy Adipose Expansion Through Suppression
   of SREBF1-Mediated Lipogenic Pathway
SO DIABETES
LA English
DT Article
ID INDUCED INSULIN-RESISTANCE; METABOLIC SYNDROME; ADIPOCYTOKINE
   DYSREGULATION; FAT DISTRIBUTION; BINDING PROTEIN; LINKS OBESITY; TISSUE;
   EXPRESSION; MICE; INFLAMMATION
AB Recent studies have emphasized the association of adipose oxidative stress (Fat reactive oxygen species [ROS]) with the pathogenesis of metabolic disorders in obesity. However, the causal roles of Fat ROS in metabolic disturbances in vivo remain unclear because no mouse model has been available in which oxidative stress is manipulated by targeting adipocytes. In this research, we generated two models of Fat ROS-manipulated mice and evaluated the metabolic features in diet-induced obesity. Fat ROS-eliminated mice, in which Cat and Sod1 were overexpressed in adipocytes, exhibited adipose expansion with decreased ectopic lipid accumulation and improved insulin sensitivity. Conversely, Fat ROS-augmented mice, in which glutathione was depleted specifically in adipocytes, exhibited restricted adipose expansion associated with increased ectopic lipid accumulation and deteriorated insulin sensitivity. In the white adipose tissues of these mice, macrophage polarization, tissue fibrosis, and de novo lipogenesis were significantly changed. In vitro approaches identified KDM1A-mediated attenuation of sterol-regulatory element-binding transcription factor 1 (SREBF1) transcriptional activities as the underlying mechanism for the suppression of de novo lipogenesis by oxidative stress. Thus, our study uncovered the novel roles of Fat ROS in healthy adipose expansion, ectopic lipid accumulation, and insulin resistance, providing the possibility for the adipocyte-targeting antioxidant therapy.
C1 [Okuno, Yosuke; Fukuhara, Atsunori; Hashimoto, Erika; Kobayashi, Hironori; Kobayashi, Sachiko; Otsuki, Michio; Shimomura, Iichiro] Osaka Univ, Grad Sch Med, Dept Metab Med, Suita, Osaka, Japan.
   [Fukuhara, Atsunori] Osaka Univ, Grad Sch Med, Dept Adipose Management, Suita, Osaka, Japan.
   [Kobayashi, Sachiko] Osaka Univ, Grad Sch Med, Dept Metab & Atherosclerosis, Suita, Osaka, Japan.
C3 The University of Osaka; The University of Osaka; The University of
   Osaka
RP Fukuhara, A (corresponding author), Osaka Univ, Grad Sch Med, Dept Metab Med, Suita, Osaka, Japan.; Fukuhara, A (corresponding author), Osaka Univ, Grad Sch Med, Dept Adipose Management, Suita, Osaka, Japan.
EM fukuhara@endmet.med.osaka-u.ac.jp
RI Fukuhara, Atsunori/A-9601-2018
OI Fukuhara, Atsunori/0000-0002-6289-3778
FU Japan Society for the Promotion of Science KAKENHI [24591329]; Japan
   Foundation for Applied Enzymology grant; Japan Health Foundation grant;
   Grants-in-Aid for Scientific Research [16K19536, 24591329] Funding
   Source: KAKEN
FX This work was supported by Japan Society for the Promotion of Science
   KAKENHI grant #24591329, a Japan Foundation for Applied Enzymology
   grant, and a Japan Health Foundation grant.
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NR 56
TC 92
Z9 98
U1 0
U2 13
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0012-1797
EI 1939-327X
J9 DIABETES
JI Diabetes
PD JUN
PY 2018
VL 67
IS 6
BP 1113
EP 1127
DI 10.2337/db17-1032
PG 15
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA GN1VD
UT WOS:000438781600010
PM 29618580
OA Bronze
DA 2025-06-11
ER

PT J
AU Abdolmaleky, HM
   Zhou, JR
AF Abdolmaleky, Hamid Mostafavi
   Zhou, Jin-Rong
TI Gut Microbiota Dysbiosis, Oxidative Stress, Inflammation, and Epigenetic
   Alterations in Metabolic Diseases
SO ANTIOXIDANTS
LA English
DT Review
DE gut dysbiosis; microbiota; microbiome; oxidative stress; inflammation;
   epigenetic; transgenerational; metabolic diseases
ID HOST; DIET; HOMEOSTASIS; BACTERIAL; CELLS; ACID
AB Gut dysbiosis, resulting from an imbalance in the gut microbiome, can induce excessive production of reactive oxygen species (ROS), leading to inflammation, DNA damage, activation of the immune system, and epigenetic alterations of critical genes involved in the metabolic pathways. Gut dysbiosis-induced inflammation can also disrupt the gut barrier integrity and increase intestinal permeability, which allows gut-derived toxic products to enter the liver and systemic circulation, further triggering oxidative stress, inflammation, and epigenetic alterations associated with metabolic diseases. However, specific gut-derived metabolites, such as short-chain fatty acids (SCFAs), lactate, and vitamins, can modulate oxidative stress and the immune system through epigenetic mechanisms, thereby improving metabolic function. Gut microbiota and diet-induced metabolic diseases, such as obesity, insulin resistance, dyslipidemia, and hypertension, can transfer to the next generation, involving epigenetic mechanisms. In this review, we will introduce the key epigenetic alterations that, along with gut dysbiosis and ROS, are engaged in developing metabolic diseases. Finally, we will discuss potential therapeutic interventions such as dietary modifications, prebiotics, probiotics, postbiotics, and fecal microbiota transplantation, which may reduce oxidative stress and inflammation associated with metabolic syndrome by altering gut microbiota and epigenetic alterations. In summary, this review highlights the crucial role of gut microbiota dysbiosis, oxidative stress, and inflammation in the pathogenesis of metabolic diseases, with a particular focus on epigenetic alterations (including histone modifications, DNA methylomics, and RNA interference) and potential interventions that may prevent or improve metabolic diseases.
C1 [Abdolmaleky, Hamid Mostafavi; Zhou, Jin-Rong] Harvard Med Sch, Beth Israel Deaconess Med Ctr, Nutr Metab Lab, Boston, MA 02215 USA.
   [Abdolmaleky, Hamid Mostafavi] Boston Univ, Chobanian & Avedisian Sch Med, Dept Med Biomed Genet, Boston, MA 02118 USA.
C3 Harvard University; Harvard University Medical Affiliates; Beth Israel
   Deaconess Medical Center; Harvard Medical School; Boston University
RP Abdolmaleky, HM; Zhou, JR (corresponding author), Harvard Med Sch, Beth Israel Deaconess Med Ctr, Nutr Metab Lab, Boston, MA 02215 USA.; Abdolmaleky, HM (corresponding author), Boston Univ, Chobanian & Avedisian Sch Med, Dept Med Biomed Genet, Boston, MA 02118 USA.
EM sabdolma@bidmc.harvard.edu; jrzhou@bidmc.harvard.edu
OI Zhou, Jin-Rong/0000-0002-6745-9495; Mostafavi Abdolmaleky,
   Hamid/0000-0002-8872-5174
FX This research received no external funding.
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NR 157
TC 56
Z9 56
U1 39
U2 51
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD AUG
PY 2024
VL 13
IS 8
AR 985
DI 10.3390/antiox13080985
PG 20
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA E8F1P
UT WOS:001305295400001
PM 39199231
OA Green Published, gold
HC Y
HP Y
DA 2025-06-11
ER

PT J
AU Wu, DM
   Wen, X
   Qu, W
   Liu, HX
   Ma, LP
   Chen, T
   Ping, J
AF Wu, Dong-Mei
   Wen, Xiao
   Qu, Wen
   Liu, Han-Xiao
   Ma, Liang-Peng
   Chen, Ting
   Ping, Jie
TI Prenatal caffeine ingestion induces long-term alterations in scavenger
   receptor class B type I expression and glucocorticoid synthesis in adult
   male offspring rat adrenals
SO FOOD AND CHEMICAL TOXICOLOGY
LA English
DT Article
DE Prenatal caffeine ingestion (PCI); Intrauterine growth retardation
   (IUGR); Scavenger receptor class B type I (SR-BI); Glucocorticoids;
   Cholesterol supply; Adrenal
ID INTRAUTERINE GROWTH-RETARDATION; BIRTH-WEIGHT; FETAL ORIGINS; METABOLIC
   SYNDROME; DNA METHYLATION; SR-BI; CHOLESTEROL; MICE; EXPOSURE; DISEASE
AB Caffeine is contained within many drinks and food that are consumed daily. Prenatal caffeine ingestion (PCI) is a risk factor for intrauterine growth retardation (IUGR). We previously observed that PCI inhibits scavenger receptor class 13 type I (SR-BI)-mediated cholesterol uptake in fetal adrenals, subsequently decreasing glucocorticoid synthesis and inducing IUGR. In the present study, we aimed to investigate the long-term effects of PCI on adrenal glucocorticoid synthesis in adult male offspring rats. After establishing the PCI-induced IUGR, adult male offspring was injected intraperitoneally with 5 mg/kg-d lipopolysaccharide (LPS) for 2 days to induce acute stress. We observed persistent inhibition of SR-BI expression in PCI adrenals before and after stress. Compared with the controls, the PCI offspring had higher corticosterone concentrations after stress. The serum cholesterol concentration was stable without intergroup differences before and after stress. The cholesterol concentration in PCI adrenals showed a higher decrease rate than that of the control after stress. In summary, PCI induced long-term alterations in SR-BI expression and glucocorticoid synthesis in adult male offspring rat adrenals. Cholesterol has to be over-consumed in PCI adrenals against acute stress. This study provides an experimental basis to explain the susceptibility of IUGR offspring to metabolic diseases in adults.
C1 [Wu, Dong-Mei; Wen, Xiao; Qu, Wen; Liu, Han-Xiao; Ma, Liang-Peng; Chen, Ting; Ping, Jie] Wuhan Univ, Sch Basic Med Sci, Dept Pharmacol, Wuhan 430071, Huibei, Peoples R China.
C3 Wuhan University
RP Ping, J (corresponding author), Wuhan Univ, Sch Basic Med Sci, Dept Pharmacol, Wuhan 430071, Huibei, Peoples R China.
EM pingjie@whu.edu.cn
RI Wu, Dongmei/AAS-6647-2020; Chen, Ting/AAY-8976-2020
FU National Natural Science Foundation of China [81673215, 81273107];
   Applied Fundamental Research Project of Wuhan [2017060201010199]
FX This work was supported by Grants from the National Natural Science
   Foundation of China (No. 81673215, 81273107), and the Applied
   Fundamental Research Project of Wuhan (No. 2017060201010199).
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NR 48
TC 1
Z9 1
U1 0
U2 11
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0278-6915
EI 1873-6351
J9 FOOD CHEM TOXICOL
JI Food Chem. Toxicol.
PD OCT
PY 2018
VL 120
BP 24
EP 31
DI 10.1016/j.fct.2018.06.056
PG 8
WC Food Science & Technology; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Toxicology
GA GX1MU
UT WOS:000447482200003
PM 29958987
DA 2025-06-11
ER

PT J
AU Ghasemi, S
   Ghanbari, A
   Rashidy-pour, A
   Bandegi, AR
AF Ghasemi, Sahar
   Ghanbari, Ali
   Rashidy-pour, Ali
   Bandegi, Ahmad Reza
TI Exercise-induced improvement of neuropathic pain in rats: Possible role
   of oxidative stress
SO BIOMEDICAL RESEARCH AND THERAPY
LA English
DT Article
DE Exercise; Neuropathic pain; Oxidative stress; Rat
ID CHRONIC CONSTRICTION INJURY; AEROBIC EXERCISE; SEX-DIFFERENCES;
   VOLUNTARY EXERCISE; GENDER-DIFFERENCES; METABOLIC SYNDROME;
   SKELETAL-MUSCLE; SPINAL-CORD; ESTROGEN; HEART
AB Introduction: Neuropathic pain is one of the main problems that succeeds a lesion or disease of the somatosensory system. In this study, the effect of exercise on oxidative stress after neuropathic pain due to sciatic nerve injury in male and female rats was evaluated.Methods: For this study, 70 adult wistar rats (35 males and 35 females) weighing 180 - 220 grams were divided into single-sex intact, sham, exercised sham, neuropathy, and exercised neuropathy groups, with 7 rats in each group. To induce neuropathy, chronic constriction injury (CCI) of the sciatic nerve was used. The exercise program included 4 weeks of swimming and medium-intensity. Von-Frey filament and plantar test devices were used to evaluate neuropathic pain. Malondialdehyde (MDA) and the ferric-reducing ability of plasma (FRAP) were determined using a spectrophotometer.Results: Our results showed that nerve damage significantly reduced the response threshold to me-chanical and thermal stimulation in both sexes, and continuous exercise significantly improved neuropathic pain in both sexes. In addition, nerve injury did not significantly generate oxidative stress in male or female rats. Meanwhile, exercise significantly reduced MDA levels and increased FRAP levels in neuropathic male rats but it did not affect oxidative stress parameters in female neuropathic rats.Conclusions: Long-term exercise reduces neuropathic pain. Swimming exercise significantly modified MDA and FRAP levels in neuropathic male rats but not in female rats. Sex hormones appear to play different roles in the oxidative stress response.
C1 [Ghasemi, Sahar] Semnan Univ Med Sci, Student Res Comm, Semnan, Iran.
   [Ghanbari, Ali; Rashidy-pour, Ali] Semnan Univ Med Sci, Res Ctr Physiol, Semnan, Iran.
   [Rashidy-pour, Ali] Semnan Univ Med Sci, Fac Med, Dept Physiol, Semnan, Iran.
   [Bandegi, Ahmad Reza] Semnan Univ Med Sci, Fac Med, Dept Biochem, Semnan, Iran.
C3 Semnan University of Medical Sciences; Semnan University of Medical
   Sciences; Semnan University of Medical Sciences; Semnan University of
   Medical Sciences
RP Ghanbari, A (corresponding author), Semnan Univ Med Sci, Res Ctr Physiol, Semnan, Iran.
EM ghanbari@semums.ac.ir
RI Bandegi, Ahmad Reza/ABG-3938-2021; Rashidy-Pour, Ali/B-5696-2018;
   Ghanbari, Ali/H-1467-2017
FU Deputy of Research and Technology of Semnan University of Medical
   Sciences, Semnan, Iran [IR.SEMUMS.REC.1398.137]
FX This study was supoorted by Deputy of Research and Technology of Semnan
   University of Medical Sciences, Semnan, Iran (permit number:
   IR.SEMUMS.REC.1398.137) .
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NR 58
TC 0
Z9 0
U1 0
U2 4
PU BIOMEDPRESS
PI HO CHI MINH
PA BIOMEDPRESS, HO CHI MINH, 00000, VIETNAM
SN 2198-4093
J9 BIOMED RES THER
JI Biomed. Res. Ther.
PY 2023
VL 10
IS 6
BP 5726
EP 5734
DI 10.15419/bmrat.v10i6.813
PG 9
WC Medicine, Research & Experimental
WE Emerging Sources Citation Index (ESCI)
SC Research & Experimental Medicine
GA Q7RN2
UT WOS:001059459800001
OA gold
DA 2025-06-11
ER

PT J
AU Aydin, S
   Bacanli, M
   Anlar, HG
   Çal, T
   Ari, N
   Bucurgat, ÜÜ
   Basaran, AA
   Basaran, N
AF Aydin, Sevtap
   Bacanli, Merve
   Anlar, Hatice Gul
   Cal, Tugbagul
   Ari, Nuray
   Bucurgat, Ulku Undeger
   Basaran, Arif Ahmet
   Basaran, Nursen
TI Preventive role of Pycnogenol® against the hyperglycemia-induced
   oxidative stress and DNA damage in diabetic rats
SO FOOD AND CHEMICAL TOXICOLOGY
LA English
DT Article
DE Diabetes; Pycnogenol; DNA damage; Oxidative stress; Hepatic enzymes
ID PINE BARK EXTRACT; LIPID-PEROXIDATION; METABOLIC SYNDROME;
   LIVER-ENZYMES; ANTIOXIDANT; COMPLICATIONS; INSULIN; PROCYANIDINS;
   IMPROVEMENT; PREVALENCE
AB Diabetes mellitus, a complex progressive metabolic disorder, leads to some oxidative stress related complications. Pycnogenol (R) (PYC), a plant extract obtained from Pinus pinaster, has been suggested to be effective in many diseases including diabetes, cancer, inflammatory and immune system disorders. The mechanisms underlying the effects of PYC in diabetes need to be elucidated. The aim of this study was to determine the effects of PYC treatment (50 mg/kg/day, orally, for 28 days) on the DNA damage and biochemical changes in the blood, liver, and kidney tissues of experimental diabetic rats. Changes in the activities of catalase, superoxide dismutase, glutathione peroxidase, glutathione reductase, and glutathione-S-transferase enzymes, and the levels of 8-hydroxy-2'-deoxyguanosine, total glutathione, malondialdehyde, insulin, total bilirubin, alanine aminotransferase, aspartate aminotransferase, gamma-glutamyl transferase, high density lipoprotein, low density lipoprotein, total cholesterol, and triglyceride were evaluated. DNA damage was also determined in the whole blood cells and the liver and renal tissue cells using the alkaline comet assay. PYC treatment significantly ameliorated the oxidative stress, lipid profile, and liver function parameters as well as DNA damage in the hyperglycemic rats. The results show that PYC treatment might improve the hyperglycemia-induced biochemical and physiological changes in diabetes.
C1 [Aydin, Sevtap; Bacanli, Merve; Bucurgat, Ulku Undeger; Basaran, Nursen] Hacettepe Univ, Dept Pharmaceut Toxicol, Fac Pharm, TR-06100 Ankara, Turkey.
   [Anlar, Hatice Gul] Zonguldak Bulent Ecevit Univ, Dept Pharmaceut Toxicol, Fac Pharm, TR-67100 Zonguldak, Turkey.
   [Cal, Tugbagul] Karadeniz Tech Univ, Dept Pharmaceut Toxicol, Fac Pharm, TR-61080 Trabzon, Turkey.
   [Ari, Nuray] Ankara Univ, Dept Pharmacol, Fac Pharm, TR-06100 Ankara, Turkey.
   [Basaran, Arif Ahmet] Hacettepe Univ, Dept Pharmacognosy, Fac Pharm, TR-06100 Ankara, Turkey.
C3 Hacettepe University; Zonguldak Bulent Ecevit University; Karadeniz
   Technical University; Ankara University; Hacettepe University
RP Aydin, S (corresponding author), Hacettepe Univ, Dept Pharmaceut Toxicol, Fac Pharm, TR-06100 Ankara, Turkey.
EM sevtapay@hacettepe.edu.tr
RI UNDEGER BUCURGAT, ULKU/J-1108-2013; Başaran, Nurşen/J-1104-2013; Çal,
   Tuğbagül/ABI-4099-2020; Ari, Nuray/AAH-6492-2020; Basaran,
   A./AAI-6606-2021; Aydin Dilsiz, Sevtap/J-1114-2013
OI Ari, Nuray/0000-0002-9259-7427; Aydin Dilsiz,
   Sevtap/0000-0002-6368-2745; CAL, TUGBAGUL/0000-0002-1476-0233
FU Scientific and Technological Research Council of Turkey [114S919]
FX This work was supported by The Scientific and Technological Research
   Council of Turkey (Grant number: 114S919).
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NR 85
TC 22
Z9 23
U1 1
U2 19
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0278-6915
EI 1873-6351
J9 FOOD CHEM TOXICOL
JI Food Chem. Toxicol.
PD FEB
PY 2019
VL 124
BP 54
EP 63
DI 10.1016/j.fct.2018.11.038
PG 10
WC Food Science & Technology; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Toxicology
GA HL4SC
UT WOS:000458712400006
PM 30465898
DA 2025-06-11
ER

PT J
AU Rahimi-Madiseh, M
   Malekpour-Tehrani, A
   Bahmani, M
   Rafieian-Kopaei, M
AF Rahimi-Madiseh, Mohammad
   Malekpour-Tehrani, Afsaneh
   Bahmani, Mahmoud
   Rafieian-Kopaei, Mahmud
TI The research and development on the antioxidants in prevention of
   diabetic complications
SO ASIAN PACIFIC JOURNAL OF TROPICAL MEDICINE
LA English
DT Review
DE Diabetic nephropathy; Natural antioxidants; Diabetes complications;
   Nephropathy; Neuropathy; Retinopathy
ID CAMELLIA-SINENSIS EXTRACT; RENAL TUBULAR CELLS; OXIDATIVE STRESS;
   KIDNEY-DISEASE; GREEN TEA; HERBAL ANTIOXIDANTS; IRANIAN POPULATION;
   METABOLIC SYNDROME; MEDICINAL-PLANTS; DRUG DISCOVERY
AB Diabetes mellitus can damage the eyes, kidneys, nerves and heart. Microvascular and macrovascular disorders are the leading causes of morbidity and mortality in diabetic patients. Hyperglycemia can increase the indicators of lipid peroxidation and oxidative stress in which free radicals have the main role in the pathogenesis of these complications. Therefore, antioxidants which combat oxidative stress should be able to prevent and repair free radicals induced damages. Although free radicals contribute to kidney damage, atherosclerosis, diabetes, heart disease, nephrotoxicity and hepatotoxicity; however, clinical trials do not uniquely confirm a substantial impact on diabetic damage. It seems that antioxidants in vegetables, fruits and grains help preventing diabetes complications; however, there is little evidence that taking single antioxidants such as vitamin E or vitamin C protect these complications. The findings about combination antioxidants are also complicated and not entirely clear. In this review paper we tried to present the role of oxidative stress on micro vascular complications of type2 diabetes mellitus. Other objective of this paper is to review the new findings about the role of various antioxidants on prevention and treatment of diabetes mellitus as well as its complications including retinopathy, nephropathy and neuropathy.
C1 [Rahimi-Madiseh, Mohammad; Rafieian-Kopaei, Mahmud] Shahrekord Univ Med Sci, Med Plants Res Ctr, Shahrekord, Iran.
   [Malekpour-Tehrani, Afsaneh] Shahrekord Univ Med Sci, Dept Social Med, Shahrekord, Iran.
   [Bahmani, Mahmoud] Fac Med, Ilam, Iran.
   [Bahmani, Mahmoud] Clin Microbiol Res Ctr, Ilam, Iran.
C3 Shahrekord University Medical Sciences; Shahrekord University Medical
   Sciences
RP Rafieian-Kopaei, M (corresponding author), Shahrekord Univ Med Sci, Med Plants Res Ctr, Shahrekord, Iran.
EM m_tahimi7@yahoo.com; rafieian@yahoo.com
RI Rafieian-Kopaei, Mahmoud/L-6532-2016; malekpour, afsaneh/L-1451-2017;
   Rahimi-madiseh, Mohammad/O-3460-2017
OI Rahimi-madiseh, Mohammad/0000-0002-3108-4708; Rafieian-kopaei,
   Mahmoud/0000-0002-1860-1141; Bahmani, Mahmoud/0000-0002-9643-9274
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NR 99
TC 93
Z9 99
U1 0
U2 24
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1995-7645
J9 ASIAN PAC J TROP MED
JI Asian Pac. J. Trop. Med.
PD SEP
PY 2016
VL 9
IS 9
BP 801
EP 808
DI 10.1016/j.apjtm.2016.07.001
PG 8
WC Public, Environmental & Occupational Health; Tropical Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health; Tropical Medicine
GA DU1HD
UT WOS:000381957900001
PM 27633293
OA gold
DA 2025-06-11
ER

PT J
AU Conceiçao, EPS
   Moura, EG
   Soares, PN
   Ai, XX
   Figueiredo, MS
   Oliveira, E
   Lisboa, PC
AF Conceicao, E. P. S.
   Moura, E. G.
   Soares, P. N.
   Ai, X. X.
   Figueiredo, M. S.
   Oliveira, E.
   Lisboa, P. C.
TI High calcium diet improves the liver oxidative stress and microsteatosis
   in adult obese rats that were overfed during lactation
SO FOOD AND CHEMICAL TOXICOLOGY
LA English
DT Article
DE Overnutrition; High calcium diet; Oxidative stress; Liver dysfunction
ID INSULIN-RESISTANCE; ELEVATION; DISEASE; FAT
AB Obesity is related to diabetes, higher oxidative stress and nonalcoholic fatty liver disease, and dietetic therapies, for instance calcium-rich diet, can improve these dysfunctions. Rats raised in small litters (SL) had increased fat depots and insulin resistance at adulthood associated with higher liver oxidative stress and microsteatosis. Thus, we evaluated if dietary calcium can improve these changes. In PN3, litter size was adjusted to 3 pups (SL group) to induce overfeeding, while controls had 10 pups until weaning. At PN120, SL group was randomly divided into: rats fed with standard chow or fed with calcium supplementation (SL-Ca group, 10 g/kg chow) for 60 days. At PN180, dietary calcium normalized food consumption, visceral fat, plasma aspartate aminotransferase (AST) and glycaemia. Concerning oxidative balance, calcium restored both higher hepatic lipid peroxidation and protein carbonylation as well as higher plasma lipid peroxidation. Higher fatty acid synthase (FAS) content, steatosis and lower protein kinase B (Akt) in SL group were normalized by dietary calcium and SL-Ca rats had lower hepatic cholesterol. Thus, calcium supplementation improved the insulin sensitivity, redox balance and steatosis in the liver. Therefore, dietary calcium can be a promising therapy for liver disease in the metabolic syndrome. (C) 2016 Elsevier Ltd. All rights reserved.
C1 [Conceicao, E. P. S.; Moura, E. G.; Soares, P. N.; Ai, X. X.; Figueiredo, M. S.; Oliveira, E.; Lisboa, P. C.] Univ Estado Rio De Janeiro, Roberto Alcantara Gomes Biol Inst, Dept Physiol Sci, Lab Endocrine Physiol, Rio De Janeiro, RJ, Brazil.
C3 Universidade do Estado do Rio de Janeiro
RP Lisboa, PC (corresponding author), Univ Estado Rio de Janeiro, Inst Biol, Dept Ciencias Fisiol, 5 AndarAv 28 Setembro,87, BR-20551031 Rio De Janeiro, RJ, Brazil.
EM pclisboa@uerj.br
RI DA COSTA OLIVEIRA, EUGÉNIO/C-6077-2009; Figueiredo,
   Mariana/KLY-7132-2024; Lisboa, Patricia/H-8336-2015; Moura,
   Egberto/H-1270-2012
OI Conceicao Furber, Ellen/0000-0003-0370-1032; Lisboa,
   Patricia/0000-0002-2477-4364; Figueiredo, Mariana/0000-0002-8539-3063;
   Moura, Egberto/0000-0002-1159-7549
FU 'National Council for Scientific and Technological Development'
   (Conselho Nacional de Desenvolvimento Cientifico e Tecnologico-CNPq);
   Coordination for the Enhancement of Higher Education Personnel
   (Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior-CAPES);
   'Carlos Chagas Filho Research Foundation of the State of Rio de Janeiro'
   (Fundacao Carlos Chagas Filho de Amparo a Pesquisa do Estado do Rio de
   Janeiro-FAPERJ); FAPERJ; CAPES
FX This research was supported by the 'National Council for Scientific and
   Technological Development' (Conselho Nacional de Desenvolvimento
   Cientifico e Tecnologico-CNPq), The Coordination for the Enhancement of
   Higher Education Personnel (Coordenacao de Aperfeicoamento de Pessoal de
   Nivel Superior-CAPES) and the 'Carlos Chagas Filho Research Foundation
   of the State of Rio de Janeiro' (Fundacao Carlos Chagas Filho de Amparo
   a Pesquisa do Estado do Rio de Janeiro-FAPERJ). EPSC is recipient of a
   FAPERJ fellowship; PNS and XXA were recipients of a CAPES fellowship.
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NR 45
TC 7
Z9 7
U1 0
U2 7
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0278-6915
EI 1873-6351
J9 FOOD CHEM TOXICOL
JI Food Chem. Toxicol.
PD JUN
PY 2016
VL 92
BP 245
EP 255
DI 10.1016/j.fct.2016.04.015
PG 11
WC Food Science & Technology; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Toxicology
GA DN1CR
UT WOS:000376804400025
PM 27108106
DA 2025-06-11
ER

PT J
AU Jorgensen, A
   Knorr, U
   Soendergaard, MG
   Lykkesfeldt, J
   Fink-Jensen, A
   Poulsen, HE
   Jorgensen, MB
   Olsen, NV
   Staalso, JM
AF Jorgensen, Anders
   Knorr, Ulla
   Soendergaard, Mia Greisen
   Lykkesfeldt, Jens
   Fink-Jensen, Anders
   Poulsen, Henrik Enghusen
   Jorgensen, Martin Balslev
   Olsen, Niels Vidiendal
   Staalso, Jonatan Myrup
TI Asymmetric dimethylarginine in somatically healthy schizophrenia
   patients treated with atypical antipsychotics: a case-control study
SO BMC PSYCHIATRY
LA English
DT Article
DE Schizophrenia; Atypical antipsychotics; Asymmetric dimethylarginine;
   Oxidative stress
ID ENDOTHELIAL FUNCTION; L-ARGININE; LIQUID-CHROMATOGRAPHY; CARDIOVASCULAR
   RISK; METABOLIC SYNDROME; PLASMA; ADMA; MORTALITY; MALTREATMENT;
   BIOMARKER
AB Background: Schizophrenia is associated with increased cardiovascular morbidity and mortality. Asymmetric dimethylarginine (ADMA), an endogenous inhibitor of the nitric oxide synthase, and the L-arginine: ADMA ratio are markers of endothelial dysfunction that predict mortality and adverse outcome in a range of cardiovascular disorders. Increased ADMA levels may also lead to increased oxidative stress. We hypothesized that ADMA and the L-arginine: ADMA ratio are increased in somatically healthy schizophrenia patients treated with atypical antipsychotics (AAP), and that the ADMA and the L-arginine: ADMA ratio are positively correlated to measures of oxidative stress.
   Methods: We included 40 schizophrenia patients treated with AAP, but without somatic disease or drug abuse, and 40 healthy controls. Plasma concentrations of ADMA and L-arginine were determined by high-performance liquid chromatography. Data were related to markers of systemic oxidative stress on DNA, RNA and lipids, as well as measures of medication load, duration of disease and current symptomatology.
   Results: Plasma ADMA and the L-arginine: ADMA ratio did not differ between schizophrenia patients and controls. Furthermore, ADMA and the L-arginine: ADMA ratio showed no correlations with oxidative stress markers, medication load, or Positive and Negative Syndrome Scale scores.
   Conclusions: Schizophrenia and treatment with AAP was not associated with increased levels of plasma ADMA or the L-arginine: ADMA ratio. Furthermore, plasma levels of ADMA were not associated with levels of systemic oxidative stress in vivo.
C1 [Jorgensen, Anders; Knorr, Ulla; Soendergaard, Mia Greisen; Fink-Jensen, Anders; Jorgensen, Martin Balslev] Univ Copenhagen Hosp, Psychiat Ctr Copenhagen, DK-2100 Copenhagen, Denmark.
   [Jorgensen, Anders; Fink-Jensen, Anders; Jorgensen, Martin Balslev; Olsen, Niels Vidiendal; Staalso, Jonatan Myrup] Univ Copenhagen, Dept Neurosci & Pharmacol, Lab Neuropsychiat, Copenhagen, Denmark.
   [Poulsen, Henrik Enghusen] Rigshosp, Lab Clin Pharmacol Q7642, DK-2100 Copenhagen, Denmark.
   [Poulsen, Henrik Enghusen] Bispebjerg Hosp, Dept Clin Pharmacol, DK-2400 Copenhagen, Denmark.
   [Lykkesfeldt, Jens; Fink-Jensen, Anders; Poulsen, Henrik Enghusen; Jorgensen, Martin Balslev] Univ Copenhagen, Fac Hlth & Med Sci, Copenhagen, Denmark.
   [Olsen, Niels Vidiendal] Rigshosp, Univ Copenhagen Hosp, Ctr Neurosci, Dept Neuroanaesthesia, DK-2100 Copenhagen, Denmark.
   [Jorgensen, Anders] Rigshosp, Univ Copenhagen Hosp, Psychiat Ctr Copenhagen, DK-2100 Copenhagen, Denmark.
C3 University of Copenhagen; Copenhagen University Hospital; University of
   Copenhagen; Rigshospitalet; University of Copenhagen; Copenhagen
   University Hospital; University of Copenhagen; Bispebjerg Hospital;
   Copenhagen University Hospital; University of Copenhagen;
   Rigshospitalet; University of Copenhagen; Copenhagen University
   Hospital; University of Copenhagen; Copenhagen University Hospital;
   Rigshospitalet
RP Jorgensen, A (corresponding author), Univ Copenhagen Hosp, Psychiat Ctr Copenhagen, DK-2100 Copenhagen, Denmark.
EM anders.01.joergensen@regionh.dk
RI Jorgensen, Anders/H-6325-2018; Jorgensen, Martin Balslev/K-5758-2012;
   Lykkesfeldt, Jens/A-1072-2011
OI Jorgensen, Anders/0000-0001-6012-6965; Poulsen, Henrik
   Enghusen/0000-0003-4242-9924; Jorgensen, Martin
   Balslev/0000-0002-1321-8901; Staalso, Jonatan Myrup/0000-0002-1702-3191;
   Knorr, Ulla/0000-0002-1222-1527; Fink-Jensen,
   Anders/0000-0001-7143-1236; Lykkesfeldt, Jens/0000-0002-6514-8407
FU Psychiatric Centre Copenhagen; Mental Health Services of the Capital
   Region of Denmark; Ivan Nielsen Foundation; Marie & Borge Krogh
   Foundation; M.D. Gerhard Linds grant; Psyciatric Research Foundation;
   Eli & Egon Larsen Foundation
FX The study was funded by the Psychiatric Centre Copenhagen and grants
   from the Mental Health Services of the Capital Region of Denmark, The
   Ivan Nielsen Foundation, The Marie & Borge Krogh Foundation, M.D.
   Gerhard Linds grant, The Psyciatric Research Foundation of 1967 and The
   Eli & Egon Larsen Foundation.
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NR 38
TC 10
Z9 11
U1 0
U2 5
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-244X
J9 BMC PSYCHIATRY
JI BMC Psychiatry
PD APR 3
PY 2015
VL 15
AR 67
DI 10.1186/s12888-015-0455-4
PG 8
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychiatry
GA CF8TR
UT WOS:000352835300001
PM 25880260
OA Green Published
DA 2025-06-11
ER

PT J
AU Bingül, I
   Aydin, AF
   Küçükgergin, C
   Dogan-Ekici, I
   Dogru-Abbasoglu, S
   Uysal, M
AF Bingul, Ilknur
   Aydin, A. Fatih
   Kucukgergin, Canan
   Dogan-Ekici, Isin
   Dogru-Abbasoglu, Semra
   Uysal, Mujdat
TI The effect of 1,25-dihydroxyvitamin D3 on liver damage, oxidative
   stress, and advanced glycation end products in experimental
   nonalcoholic- and alcoholic- fatty liver disease
SO TURKISH JOURNAL OF MEDICAL SCIENCES
LA English
DT Article
DE Vitamin D; fructose; ethanol; oxidative stress; glycation end products
ID VITAMIN-D PREVENTS; METABOLIC SYNDROME; BETAINE TREATMENT; D DEFICIENCY;
   RATS; ANTIOXIDANT; FIBROSIS; INJURY; SUPPLEMENTATION; INFLAMMATION
AB Background/aim: Oxidative stress and advanced glycation end products (AGEs) formation are proposed as effective mechanisms in the pathogenesis of nonalcoholic fatty liver disease (NAFLD) and alcoholic liver disease (ALD). 1,25(OH)(2)D-3 was proposed to have antioxidant, antiinflammatory and antiglycation properties. In this study, the effect of 1,25(OH)(2)D-3 treatment on oxidative stress parameters and AGEs levels together with hepatic histopathology was investigated in high fructose (HFr) or ethanol (EtOH)-treated rats.
   Materials and methods: Rats were treated with fructose (30%) or ethanol (5-20%) in drinking water with and without 1,25(OH)(2)D-3 treatment (5 mu g/kg two times a week) for 8 weeks. Insulin resistance (IR), oxidative stress parameters, AGEs, triglyceride (TG), and hydroxyproline (Hyp) levels together with histopathology were investigated in the liver.
   Results: 1,25(OH)(2)D-3 decreased hepatic reactive oxygen species, lipid and protein oxidation products together with histopathological improvements in HFr- and EtOH-treated rats. 1,25(OH)(2)D-3 treatment was observed to decrease significantly serum and hepatic AGEs in HFr group, and hepatic AGEs in EtOH group.
   Conclusion: Our results clearly show that 1,25(OH)(2)D-3 treatment may be useful in the alleviation of hepatic lesions by decreasing glycooxidant stress in both NAFLD and ALD models created by HFr- and EtOH-treated rats, respectively.
C1 [Bingul, Ilknur; Aydin, A. Fatih; Kucukgergin, Canan; Dogru-Abbasoglu, Semra] Istanbul Univ, Istanbul Med Fac, Dept Med Biochem, Istanbul, Turkey.
   [Dogan-Ekici, Isin] Acibadem Univ, Dept Pathol, Fac Med, Istanbul, Turkey.
   [Uysal, Mujdat] Tayyareci Nurettin Sokak, Istanbul, Turkey.
C3 Istanbul University; Acibadem University
RP Bingül, I (corresponding author), Istanbul Univ, Istanbul Med Fac, Dept Med Biochem, Istanbul, Turkey.
EM ilknur.bingul@istanbul.edu.tr
RI Bingul, Ilknur/AAD-9926-2020; Aydın, Abdurrahman/AAD-9170-2020;
   Küçükgergin, Canan/AAD-9925-2020; Abbasoglu, Semra/AAD-9014-2020
OI Dogan Ekici, Asiye Isin/0000-0003-4062-9519
FU Research Fund of stanbul University [30443]
FX The present work was supported by Research Fund of stanbul University
   (Project No: 30443) . We would like to thank the VEM ILAC San. A.S. for
   supporting us in providing Ostriol material.
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U1 0
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PU Tubitak Scientific & Technological Research Council Turkey
PI ANKARA
PA ATATURK BULVARI NO 221, KAVAKLIDERE, TR-06100 ANKARA, TURKIYE
SN 1300-0144
EI 1303-6165
J9 TURK J MED SCI
JI Turk. J. Med. Sci.
PY 2021
VL 51
IS 3
BP 1500
EP 1511
DI 10.3906/sag-2007-289
PG 12
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA TB9IJ
UT WOS:000668257500012
PM 33421970
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Wachira, SJ
   Hughes-Darden, CA
   Nicholas, HB
   Taylor, CV
   Robinson, TJ
AF Wachira, SJ
   Hughes-Darden, CA
   Nicholas, HB
   Taylor, CV
   Robinson, TJ
TI Neural melanocortin receptors are differentlally expressed and regulated
   by stress in rat hypothalamic-pituitary-adrenal axis
SO CELLULAR AND MOLECULAR BIOLOGY
LA English
DT Article
DE hypothalamic-pituitary-adrenal axis (HPA); proopiomelanocortin;
   melanocortin receptor; REM-sleep deprivation; stress
ID CELL-SURFACE EXPRESSION; AGOUTI-RELATED PROTEIN; SLEEP-DEPRIVATION;
   PROOPIOMELANOCORTIN; SEQUENCE; HORMONE; DISRUPTION; MUTATIONS; PEPTIDES;
   TERMINUS
AB Genetic knockout and null mutations of melanocortin system components lead to phenotypes that recapitulate the metabolic syndrome such as obesity, hypertension and insulin resistance. Since stress is known to modify metabolic and cardiovascular function, we hypothesized the involvement of the neural melanocortin system in the stress response. Male rats were subjected to rapid-eye-movement sleep deprivation stress and the levels of proopiomelanocortin (POMC), MC3R, MC4R and MC5R transcripts in the hypothalamic-pituitary-adrenal axis (HPA) determined by real-time PCR. Increased levels of POMC transcripts were observed in the hypothalamus and adrenal gland tissues but there were no significant changes in the expression of the receptors genes. Whereas MOR and MOR are expressed in all HPA tissues, MC4R seems to be restricted mainly to the hypothalamus. It is possible that melanocortin receptors function in different aspects of the neuron. In vitro studies showed similar cellular distribution patterns for MOR and MC4R and sequence analyses revealed strong conservation of the putative G-protein coupled receptors (GPCR) C-terminal membrane localization signal, EX(3-7)II/L motif, in MC3R, MC4R and MC5R. These data suggest that the physiological roles of neural melanocortin receptors, MOR and MC4R, are likely determined by distinct tissue distribution patterns and suggest a role for hypothalamic and intra-adrenal melanocortin systems in the manifestation of stress related pathologies.
C1 Morgan State Univ, Dept Biol, Baltimore, MD 21251 USA.
   NIH, Res Ctr, Pittsburgh Supercomp Ctr, Pittsburgh, PA 15213 USA.
C3 Morgan State University; Pennsylvania Commonwealth System of Higher
   Education (PCSHE); University of Pittsburgh; National Institutes of
   Health (NIH) - USA
RP Morgan State Univ, Dept Biol, 1700 E Cold Spring Lane, Baltimore, MD 21251 USA.
EM jwachir@morgan.edu
FU NCRR NIH HHS [G12 RR 017581, P41 RR 06009] Funding Source: Medline;
   NIGMS NIH HHS [2 S06 GM 051971-08, T36 GM 08789] Funding Source: Medline
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NR 50
TC 12
Z9 13
U1 0
U2 4
PU C M B  ASSOC
PI POITIERS
PA 34 BOULEVARD SOLFERINO, 86000 POITIERS, FRANCE
SN 0145-5680
EI 1165-158X
J9 CELL MOL BIOL
JI Cell. Mol. Biol.
PD SEP
PY 2004
VL 50
IS 6
BP 703
EP 713
PG 11
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA 881UG
UT WOS:000225894300004
PM 15641161
DA 2025-06-11
ER

PT J
AU Dastkhosh, A
   Behrouz, V
   Sohrab, G
   Nikpayam, O
   Sedaghat, M
   Ebrahimof, S
AF Dastkhosh, Ali
   Behrouz, Vahideh
   Sohrab, Golbon
   Nikpayam, Omid
   Sedaghat, Meghdad
   Ebrahimof, Samira
TI What are the effects of crocin supplementation on lipid profile and
   oxidative stress in patients with type 2 diabetes? A randomized clinical
   trial
SO JOURNAL OF FUNCTIONAL FOODS
LA English
DT Article
DE Crocin; Oxidative Stress; Lipid Profile; Diabetes Mellitus
ID SATIVUS L.; SAFFRON SUPPLEMENTATION; METABOLIC SYNDROME; DOUBLE-BLIND;
   INFLAMMATION; ANTIOXIDANT; CONSTITUENT; PARAMETERS; INSULIN
AB Type 2 diabetes mellitus (T2DM) and its complications are a life threat to people across the world. Today's dietary supplement received much attention as a complementary therapy to reduce the risk of disease and its complications. Available data indicated the beneficial effects of crocin, a carotenoid compound, on T2DM complications; however, there is still no consolidated conclusion about this. So, this study aimed to evaluate the effects of crocin supplementation on lipid profile and oxidative stress in patients with T2DM. In the present study with a parallel-group design, 50 patients with T2DM were randomly assigned to either receive 30 mg crocin or placebo for 12 weeks. Anthropometric measurements, body fat, lipid profile, and oxidative stress were assessed at the beginning and the end of the intervention. Based on the analysis crocin supplementation in comparison with placebo significantly reduced plasma levels of triglyceride (TG) (p = 0.003) and total Oxidant Status (TOS) (p = 0.016), but didn't have any impressive effect on other factors. According to the present study crocin supplementation can probably improve the plasma levels of TG and TOS in patients with T2DM, although further studies are needed to confirm these findings.
C1 [Dastkhosh, Ali; Sohrab, Golbon] Shahid Beheshti Univ Med Sci, Natl Nutr & Food Technol Res Inst, Fac Nutr Sci & Food Technol, Dept Clin Nutr & Dietet, Tehran, Iran.
   [Behrouz, Vahideh] Kerman Univ Med Sci, Fac Publ Hlth, Dept Nutr, Kerman, Iran.
   [Nikpayam, Omid] Golestan Univ Med Sci, Sch Hlth, Dept Nutr, Gorgan, Iran.
   [Sedaghat, Meghdad] Shahid Beheshti Univ Med Sci, Imam Hossein Gen Hosp, Dept Internal Med, Tehran, Iran.
   [Ebrahimof, Samira] Shahid Beheshti Univ Med Sci, Natl Nutr & Food Technol Res Inst, Fac Nutr Sci & Food Technol, Dept Nutr Res, Tehran, Iran.
C3 Shahid Beheshti University Medical Sciences; Kerman University of
   Medical Sciences; Golestan University of Medical Sciences; Shahid
   Beheshti University Medical Sciences; Shahid Beheshti University Medical
   Sciences
RP Nikpayam, O (corresponding author), Golestan Univ Med Sci, Sch Hlth, Dept Nutr, Gorgan, Iran.; Sohrab, G (corresponding author), Natl Nutr & Food Technol Res Inst, Fac Nutr Sci & Food Technol, Dept Clin Nutr & Dietet, Tehran, Iran.
EM golbonsohrab@sbmu.ac.ir; Dr.nikpayam.o@goums.ac.ir
RI Nikpayam, Omid/AGG-5000-2022; behrouz, vahideh/AAL-5105-2020; Sohrab,
   Golbon/AHE-4922-2022
FU National Nutrition and Food Technology Research Institute, Shahid
   Beheshti University of Medical Sciences
FX The present study was supported by a grant from the National Nutrition
   and Food Technology Research Institute, Shahid Beheshti University of
   Medical Sciences.
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NR 45
TC 1
Z9 2
U1 0
U2 1
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1756-4646
EI 2214-9414
J9 J FUNCT FOODS
JI J. Funct. Food.
PD OCT
PY 2024
VL 121
AR 106396
DI 10.1016/j.jff.2024.106396
EA AUG 2024
PG 8
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA D7F8T
UT WOS:001297813100001
OA gold
DA 2025-06-11
ER

PT J
AU Lipke, K
   Kubis-Kubiak, A
   Piwowar, A
AF Lipke, Katarzyna
   Kubis-Kubiak, Adriana
   Piwowar, Agnieszka
TI Molecular Mechanism of Lipotoxicity as an Interesting Aspect in the
   Development of Pathological States-Current View of Knowledge
SO CELLS
LA English
DT Review
DE lipotoxicity; fatty acid; oxidative stress; insulin resistance;
   inflammation
ID ENDOPLASMIC-RETICULUM STRESS; SATURATED FATTY-ACIDS; INDUCED
   INSULIN-RESISTANCE; PROTEIN-KINASE-C; PANCREATIC-BETA-CELLS;
   SKELETAL-MUSCLE CELLS; PALMITATE-INDUCED APOPTOSIS; INDUCED OXIDATIVE
   STRESS; KAPPA-B ACTIVATION; ER STRESS
AB Free fatty acids (FFAs) play numerous vital roles in the organism, such as contribution to energy generation and reserve, serving as an essential component of the cell membrane, or as ligands for nuclear receptors. However, the disturbance in fatty acid homeostasis, such as inefficient metabolism or intensified release from the site of storage, may result in increased serum FFA levels and eventually result in ectopic fat deposition, which is unfavorable for the organism. The cells are adjusted for the accumulation of FFA to a limited extent and so prolonged exposure to elevated FFA levels results in deleterious effects referred to as lipotoxicity. Lipotoxicity contributes to the development of diseases such as insulin resistance, diabetes, cardiovascular diseases, metabolic syndrome, and inflammation. The nonobvious organs recognized as the main lipotoxic goal of action are the pancreas, liver, skeletal muscles, cardiac muscle, and kidneys. However, lipotoxic effects to a significant extent are not organ-specific but affect fundamental cellular processes occurring in most cells. Therefore, the wider perception of cellular lipotoxic mechanisms and their interrelation may be beneficial for a better understanding of various diseases' pathogenesis and seeking new pharmacological treatment approaches.
C1 [Lipke, Katarzyna; Kubis-Kubiak, Adriana; Piwowar, Agnieszka] Wroclaw Med Univ, Fac Pharm, Dept Toxicol, PL-50367 Wroclaw, Poland.
C3 Wroclaw Medical University
RP Lipke, K (corresponding author), Wroclaw Med Univ, Fac Pharm, Dept Toxicol, PL-50367 Wroclaw, Poland.
EM katarzyna.lipke@wp.pl; adriana.kubis-kubiak@umw.edu.pl;
   agnieszka.piwowar@umw.edu.pl
RI Ku, Adri/AAX-1814-2020
OI Piwowar, Agnieszka/0000-0001-6971-3883; Kubis,
   Adriana/0000-0001-6823-1268
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NR 257
TC 66
Z9 75
U1 1
U2 22
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2073-4409
J9 CELLS-BASEL
JI Cells
PD MAR
PY 2022
VL 11
IS 5
AR 844
DI 10.3390/cells11050844
PG 34
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA ZT1OF
UT WOS:000768924100001
PM 35269467
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Song, BJ
   Abdelmegeed, MA
   Henderson, LE
   Yoo, SH
   Wan, J
   Purohit, V
   Hardwick, JP
   Moon, KH
AF Song, Byoung-Joon
   Abdelmegeed, Mohamed A.
   Henderson, Lauren E.
   Yoo, Seong-Ho
   Wan, Jie
   Purohit, Vishnudutt
   Hardwick, James P.
   Moon, Kwan-Hoon
TI Increased Nitroxidative Stress Promotes Mitochondrial Dysfunction in
   Alcoholic and Nonalcoholic Fatty Liver Disease
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Review
ID ASCORBATE-DEPENDENT ARTIFACT; ALDEHYDE-DEHYDROGENASE; OXIDATIVE STRESS;
   NITRIC-OXIDE; CYTOCHROME-P450 2E1; LIPID-PEROXIDATION; PPAR-ALPHA;
   MOLECULAR-MECHANISMS; GEL-ELECTROPHORESIS; HYDROGEN-PEROXIDE
AB Increased nitroxidative stress causes mitochondrial dysfunctions through oxidative modifications of mitochondrial DNA, lipids, and proteins. Persistent mitochondrial dysfunction sensitizes the target cells/organs to other pathological risk factors and thus ultimately contributes to the development of more severe disease states in alcoholic and nonalcoholic fatty liver disease. The incidences of nonalcoholic fatty liver disease continuously increase due to high prevalence of metabolic syndrome including hyperlipidemia, hypercholesterolemia, obesity, insulin resistance, and diabetes. Many mitochondrial proteins including the enzymes involved in fat oxidation and energy supply could be oxidatively modified (including S-nitrosylation/ nitration) under increased nitroxidative stress and thus inactivated, leading to increased fat accumulation and ATP depletion. To demonstrate the underlying mechanism(s) of mitochondrial dysfunction, we employed a redox proteomics approach using biotin-N-maleimide (biotin-NM) as a sensitive biotin-switch probe to identify oxidized Cys residues of mitochondrial proteins in the experimental models of alcoholic and acute liver disease. The aims of this paper are to briefly describe the mechanisms, functional consequences, and detection methods of mitochondrial dysfunction. We also describe advantages and limitations of the Cys-targeted redox proteomics method with alternative approaches. Finally, we discuss various applications of this method in studying oxidatively modified mitochondrial proteins in extrahepatic tissues or different subcellular organelles and translational research.
C1 [Song, Byoung-Joon; Abdelmegeed, Mohamed A.; Henderson, Lauren E.; Yoo, Seong-Ho; Wan, Jie; Moon, Kwan-Hoon] NIAAA, Sect Mol Pharmacol & Toxicol, Lab Membrane Biochem & Biophys, Bethesda, MD 20892 USA.
   [Yoo, Seong-Ho] Seoul Natl Univ, Coll Med, Dept Forens Med, Seoul 110, South Korea.
   [Purohit, Vishnudutt] Natl Inst Drug Abuse, Bethesda, MD 20892 USA.
   [Hardwick, James P.] Northeastern Ohio Univ Coll Med & Pharm, Coll Med, Dept Integrat Med Sci, Rootstown, OH 44272 USA.
   [Moon, Kwan-Hoon] Loyola Univ, Med Ctr, Dept Mol Pharmacol & Therapeut, Maywood, IL 60153 USA.
C3 National Institutes of Health (NIH) - USA; NIH National Institute on
   Alcohol Abuse & Alcoholism (NIAAA); Seoul National University (SNU);
   National Institutes of Health (NIH) - USA; NIH National Institute on
   Drug Abuse (NIDA); University System of Ohio; Northeast Ohio Medical
   University (NEOMED); Loyola University Chicago
RP Song, BJ (corresponding author), NIAAA, Sect Mol Pharmacol & Toxicol, Lab Membrane Biochem & Biophys, 9000 Rockville Pike, Bethesda, MD 20892 USA.
EM bj.song@nih.gov
RI Yoo, Sung/J-5549-2012; Wan, Jieru/AAH-2860-2020
FU Intramural Program Fund at the National Institute on Alcohol Abuse and
   Alcoholism; Grant for the Chronic Liver Disease Project from the Center
   for Biological Modulators in the Republic of Korea
FX This research was supported by the Intramural Program Fund at the
   National Institute on Alcohol Abuse and Alcoholism. Part of this
   research was also supported by a Grant for the Chronic Liver Disease
   Project (to B. J. Song) from the Center for Biological Modulators in the
   Republic of Korea. The authors thank Dr. Klaus Gawrisch for his support.
   They are also grateful to Drs. Timothy D. Veenstra, Brian L. Hood,
   Thomas P. Conrads, Li-Rong Yu, and Xiaoying Ye at the Laboratory of
   Proteomics and Analytical Technologies, Advanced Technology Program,
   SAIC-Frederick, Inc., for determining the protein sequences of
   oxidatively modified mitochondrial proteins in our studies. The authors
   do not have any conflict of interest.
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NR 146
TC 52
Z9 55
U1 0
U2 19
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PY 2013
VL 2013
AR 781050
DI 10.1155/2013/781050
PG 14
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA 125AO
UT WOS:000317510700001
PM 23691267
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Jimenez, R
   Toral, M
   Gómez-Guzmán, M
   Romero, M
   Sanchez, M
   Mahmoud, AM
   Duarte, J
AF Jimenez, Rosario
   Toral, Marta
   Gomez-Guzman, Manuel
   Romero, Miguel
   Sanchez, Manuel
   Mahmoud, Ayman M.
   Duarte, Juan
TI The Role of Nrf2 Signaling in PPARβ/δ-Mediated Vascular Protection
   against Hyperglycemia-Induced Oxidative Stress
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Article
ID INDUCED ENDOTHELIAL DYSFUNCTION; NITRIC-OXIDE SYNTHASE;
   DIABETES-MELLITUS; HEME OXYGENASE-1; NAD(P)H OXIDASE; NADPH OXIDASE;
   HIGH GLUCOSE; METABOLIC SYNDROME; INDUCED IMPAIRMENT; HUMAN-DISEASE
AB Hyperglycemia induces oxidative stress and plays a substantial role in the progression of vascular diseases. Here, we demonstrated the potentiality of peroxisome proliferator-activated receptor (PPAR) beta/delta activation in attenuating high glucose-induced oxidative stress in endothelial cells and diabetic rats, pointing to the involvement of nuclear factor erythroid 2-related factor 2 (Nrf2). HUVECs exposed to high glucose showed increased levels of reactive oxygen species (ROS) and upregulated NOX-2, NOX-4, Nrf2, and NQO-1 effects that were significantly reversed by the PPAR beta/delta agonists GW0742 and L165041. Both PPAR beta/delta agonists, in a concentration-dependent manner, induced transcriptional and protein upregulation of heme oxygenase-1 (HO-1) under low- and high-glucose conditions. All effects of PPAR beta/delta agonists were reversed by either pharmacological inhibition or siRNA-based downregulation of PPAR beta/delta. These in vitro findings were confirmed in diabetic rats treated with GW0742. In conclusion, PPAR beta/delta activation confers vascular protection against hyperglycemia-induced oxidative stress by suppressing NOX-2 and NOX-4 expression plus a direct induction of HO-1; with the subsequent downregulation of the Nrf2 pathway. Thus, PPAR beta/delta activation could be of interest to prevent the progression of diabetic vascular complications.
C1 [Jimenez, Rosario; Toral, Marta; Gomez-Guzman, Manuel; Romero, Miguel; Sanchez, Manuel; Duarte, Juan] Univ Granada, Sch Pharm, Dept Pharmacol, Granada, Spain.
   [Jimenez, Rosario; Romero, Miguel; Sanchez, Manuel; Duarte, Juan] Inst Invest Biosanitaria Granada Ibs GRANADA, Granada, Spain.
   [Jimenez, Rosario; Duarte, Juan] Ciber Enfermedades Cardiovasc CIBERCV, Granada, Spain.
   [Mahmoud, Ayman M.] Beni Suef Univ, Fac Sci, Dept Zool, Physiol Div, Bani Suwayf, Egypt.
   [Mahmoud, Ayman M.] Charite Univ Med Berlin, Dept Endocrinol Diabet & Nutr, Berlin, Germany.
   [Mahmoud, Ayman M.] Charite Univ Med Berlin, CCR, Dept Endocrinol Diabet & Nutr, Berlin, Germany.
C3 University of Granada; Instituto de Investigacion Biosanitaria IBS
   Granada; CIBER - Centro de Investigacion Biomedica en Red; CIBERCV;
   Egyptian Knowledge Bank (EKB); Beni Suef University; Berlin Institute of
   Health; Free University of Berlin; Humboldt University of Berlin;
   Charite Universitatsmedizin Berlin; Berlin Institute of Health; Free
   University of Berlin; Humboldt University of Berlin; Charite
   Universitatsmedizin Berlin
RP Jimenez, R (corresponding author), Univ Granada, Sch Pharm, Dept Pharmacol, Granada, Spain.; Jimenez, R (corresponding author), Inst Invest Biosanitaria Granada Ibs GRANADA, Granada, Spain.; Jimenez, R (corresponding author), Ciber Enfermedades Cardiovasc CIBERCV, Granada, Spain.
EM rjmoleon@ugr.es
RI Duarte, Juan/AAH-1574-2020; Toral, Marta/K-6709-2014; Duarte,
   Juan/K-6472-2014; Gomez-Guzman, Manuel/E-3341-2012; Romero,
   Miguel/K-6053-2014; Mahmoud, Ayman/S-2613-2016; JIMENEZ,
   ROSARIO/K-9701-2014; Sanchez, Manuel/C-4401-2008
OI Toral, Marta/0000-0001-5324-8569; Duarte, Juan/0000-0002-9153-5857;
   Gomez-Guzman, Manuel/0000-0003-2452-9286; Romero,
   Miguel/0000-0003-0578-1099; Mahmoud, Ayman/0000-0003-0279-6500; JIMENEZ,
   ROSARIO/0000-0003-3872-2669; Sanchez, Manuel/0000-0002-3975-3398
FU Ministerio de Economia y Competitividad [SAF2010-22066-C02-01,
   SAF2010-22066-C02-02, SAF2011-28150, SAF2014-55523-R]; Fondo Europeo de
   Desarrollo Regional (FEDER) [SAF2010-22066-C02-01, SAF2010-22066-C02-02,
   SAF2011-28150, SAF2014-55523-R]; Junta de Andalucia (Proyecto de
   excelencia) [P12-CTS-2722]; Instituto de Salud Carlos III, Spain [RIC
   RD12/0042/0011]
FX This work was supported by Grants from Ministerio de Economia y
   Competitividad and Fondo Europeo de Desarrollo Regional (FEDER)
   (SAF2010-22066-C02-01, SAF2010-22066-C02-02, SAF2011-28150,
   SAF2014-55523-R), Junta de Andalucia (Proyecto de excelencia,
   P12-CTS-2722), and Instituto de Salud Carlos III (RIC RD12/0042/0011),
   Spain.
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NR 42
TC 35
Z9 36
U1 0
U2 7
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PY 2018
VL 2018
AR 5852706
DI 10.1155/2018/5852706
PG 12
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA GM2QR
UT WOS:000437935200001
PM 30046379
OA Green Published, hybrid, Green Submitted
DA 2025-06-11
ER

PT J
AU Liu, JX
   Li, D
   Zhang, T
   Tong, Q
   Ye, RD
   Lin, LG
AF Liu, Jingxin
   Li, Dan
   Zhang, Tian
   Tong, Qiang
   Ye, Richard Dequan
   Lin, Ligen
TI SIRT3 protects hepatocytes from oxidative injury by enhancing ROS
   scavenging and mitochondrial integrity
SO CELL DEATH & DISEASE
LA English
DT Article
ID LIVER-DISEASES; DEPENDENT DEACETYLASE; LYSINE ACETYLATION; METABOLIC
   SYNDROME; SKELETAL-MUSCLE; FATTY LIVER; CELL-DEATH; STRESS; AMPK;
   EXPRESSION
AB Evidences of oxidative stress and mitochondrial dysfunction have been recognized in most of clinical and experimental liver diseases. SIRT3, a member of NAD(+)-dependent deacetylases, is mainly localized in mitochondria. So far, the role of SIRT3 in protecting hepatocytes against oxidative stress remains elusive. Herein, we found SIRT3 protein expression is decreased in tertbutyl hydroperoxide (t-BHP)-treated AML12 cells in vitro and primary hepatocytes from CCI4-injured mice in vivo. To further verify the role of SIRT3 in protecting hepatocytes from t-BHP-induced injury, SIRT3 overexpressed AML12 cell line and primary hepatocytes were generated. SIRT3 overexpressed hepatocytes showed improved cell viability upon t-BHP challenge, with less intracellular reactive oxygen species (ROS) accumulation. SIRT3 overexpression reduced superoxide dismutase 2 acetylation level and stimulated nuclear factor erythroid 2-related factor 2 nuclear translocation to enhance anti-oxidative capacity. Moreover, SIRT3 deacetylated peroxisome proliferator-activated receptor. coactivator 1 alpha to promote mitochondrial biogenesis, and 8-oxoguanine DNA glycosylase 1 to orchestrate DNA repair, resulting in improved mitochondrial function. Through deacetylating Ku70, SIRT3 also abated mitochondrial translocation of dynamin-related protein 1, to attenuate mitochondrial fragmentation in t-BHP-injured hepatocytes. These results suggested that SIRT3 protected hepatocytes against oxidative stress by enhancing ROS scavenging and maintaining mitochondrial integrity.
C1 [Liu, Jingxin; Li, Dan; Zhang, Tian; Ye, Richard Dequan; Lin, Ligen] Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Ave Univ, Macau 999078, Peoples R China.
   [Tong, Qiang] Baylor Coll Med, Childrens Nutr Res Ctr, Houston, TX 77030 USA.
C3 University of Macau; Baylor College of Medicine
RP Lin, LG (corresponding author), Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Ave Univ, Macau 999078, Peoples R China.
EM ligenl@umac.mo
RI Lin, Ligen/ABC-1078-2020; Tian, Zhang/JSL-7966-2023; Ye,
   Richard/ABF-2413-2020; Liu, Jingxin/AAW-9254-2021
OI Liu, Jingxin/0000-0001-6637-6076
FU Science and Technology Development Fund, Macao SAR (FDCT) [120/2013/A3];
   Research Fund of University of Macau [MYRG2015-00153-ICMS-QRCM,
   MYRG2017-00109-ICMS-QRCM]
FX Financial support by Science and Technology Development Fund, Macao SAR
   (FDCT 120/2013/A3) and the Research Fund of University of Macau
   (MYRG2015-00153-ICMS-QRCM and MYRG2017-00109-ICMS-QRCM) are gratefully
   acknowledged.
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NR 57
TC 119
Z9 128
U1 2
U2 22
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 2041-4889
J9 CELL DEATH DIS
JI Cell Death Dis.
PD OCT
PY 2017
VL 8
AR e3158
DI 10.1038/cddis.2017.564
PG 11
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA FL2CV
UT WOS:000414022900001
PM 29072685
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Zhang, ZZ
   Wu, S
   Muhammad, S
   Ren, Q
   Sun, C
AF Zhang, Zhenzhen
   Wu, Song
   Muhammad, Saeed
   Ren, Qian
   Sun, Chao
TI miR-103/107 promote ER stress-mediated apoptosis via targeting the
   Wnt3a/β-catenin/ATF6 pathway in preadipocytes
SO JOURNAL OF LIPID RESEARCH
LA English
DT Article
DE miR-103 and miR-107; endoplasmic reticulum stress; WNT family member
   3a/beta-catenin-activating transcription factor 6 pathway
ID UNFOLDED PROTEIN RESPONSE; ADIPOSE-TISSUE; TNF-ALPHA; WNT PATHWAY;
   MICRORNAS; DISEASE; CATENIN; OBESITY; METABOLISM; LEPTIN
AB Both miR-103 and miR-107 have been demonstrated to restrain cell proliferation and regulate lipid metabolism and inflammation. However, the effects of miR103/107 on preadipocyte apoptosis remain unknown. In the present research, we have investigated how miR-103/107 regulated preadipocyte apoptosis. We found that miR103/107 aggravated endoplasmic reticulum (ER) stress-mediated apoptosis in preadipocytes. We confirmed that miR-103/107 targeted WNT family member 3a (Wnt3a) in preadipocytes. It was found that overexpressing Wnt3a resulted in suppression of ER stress-mediated apoptosis, while restoration of miR-103/107 counteracted the effects of Wnt3a in preadipocytes. Moreover, bioinformatics and luciferase assays indicated that activating transcription factor (ATF) 6 is a key player linking miR-103/107-induced ER stress to apoptosis. ATF6 is regulated by lymphoid enhancerbinding factor 1, a transcription factor downstream of the Wnt3a/beta-catenin signaling pathway, and ATF6 binds to the B-cell lymphoma 2 (Bcl2) promoter to regulate apoptosis further. In conclusion, miR-103/107 promoted ER stress-mediated apoptosis by targeting the Wnt3a/beta-catenin/ATF6 signaling pathway in preadipocytes. This study revealed that the miR-103/107-Wnt3a/beta-catenin-ATF6 pathway is critical to the progression of apoptosis in preadipocytes, which suggested that approaches to activate miR-103/107 could potentially be useful as new therapies for treating obesity and metabolic syndrome-related disorders.
C1 [Zhang, Zhenzhen; Wu, Song; Muhammad, Saeed; Ren, Qian; Sun, Chao] Northwest A&F Univ, Coll Anim Sci & Technol, Yangling 712100, Shaanxi, Peoples R China.
C3 Northwest A&F University - China
RP Sun, C (corresponding author), Northwest A&F Univ, Coll Anim Sci & Technol, Yangling 712100, Shaanxi, Peoples R China.
EM schao@nwsuaf.edu.cn
RI ren, qian/ABE-4426-2021; Saeed, Muhammad/D-1844-2017
OI Saeed, Muhammad/0000-0001-5048-5753; Sun, Chao/0000-0001-7222-4028
FU Major National Scientific Research Projects [2015CB943102]; National
   Natural Science Foundation of China [31572365]; Key Sci-Tech Innovation
   Team of Shaanxi Province [2017KCT-24]; Key Sci-Tech Innovation Team of
   Northwest AF University
FX This study was financially supported by Major National Scientific
   Research Projects Grant 2015CB943102, National Natural Science
   Foundation of China Grant 31572365, Key Sci-Tech Innovation Team of
   Shaanxi Province Grant 2017KCT-24, and the Key Sci-Tech Innovation Team
   of Northwest A&F University. The authors declare no conflicts of
   interest.
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NR 46
TC 75
Z9 84
U1 1
U2 12
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0022-2275
EI 1539-7262
J9 J LIPID RES
JI J. Lipid Res.
PD MAY
PY 2018
VL 59
IS 5
BP 843
EP 853
DI 10.1194/jlr.M082602
PG 11
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA GE3IQ
UT WOS:000431107400011
PM 29483204
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Alsolami, K
   Hamza, RZ
AF Alsolami, Khadeejah
   Hamza, Reham Z.
TI Orlistat and metformin combination ameliorates obesity-induced renal
   injury via suppressing renal oxidative stress in male rats
SO TOXICOLOGY RESEARCH
LA English
DT Article
DE nephrotoxicity; renal toxicity; excessive weight; orlistat; metformin;
   obesity; oxidative stress; kidney functions
ID CARDIOVASCULAR RISK PROFILE; METABOLIC SYNDROME; TISSUE; ASSAY; MEN
AB Background: Orlistat (ORS) and metformin (MEF) are robustly used as well-established clinical drugs for the treatment for both obesity and the consequences of diabetes mellitus. Additionally, no study has been conducted to explore the consequence of the combination of both ORS and MEF on the kidneys of rats with obesity-induced renal injury (OBS). Objectives: Therefore, the objective of the current research was designed to explore the possible ameliorative effects of either ORS and/or MEF or their combination against obesity (OBS) induced experimental renal oxidative stress. Methods: Renal oxidative stress was investigated at redox histopathological and immunohistological points in the kidney tissues. Results: The levels of urea, uric acid, and creatinine increased with the obesity effect; in addition, the myeloperoxidase (MPO) and xanthine oxidase (XO) activators were elevated significantly with the induction of OBS. The levels of non-enzymatic antioxidants (glutathione and thiol) declined sharply in OBS rats as compared to the normal group. Conclusion: The data displayed that the combination of both ORS and MEF declined the obesity effects significantly by reducing the level of peroxidation (MDA), and enhancement intracellular antioxidant enzymes. These biochemical findings were supported by histopathology, immunohistochemistry, and Masson-Trichrome evaluation, which showed minor morphological changes in the kidneys of rats.
   Graphical Abstract
C1 [Alsolami, Khadeejah] Taif Univ, Coll Pharm, Pharmacol & Toxicol Dept, POB 11099, Taif 21944, Saudi Arabia.
   [Hamza, Reham Z.] Taif Univ, Coll Sci, Biol Dept, POB 11099, Taif 21944, Saudi Arabia.
C3 Taif University; Taif University
RP Hamza, RZ (corresponding author), Taif Univ, Coll Sci, Dept Biol, POB 11099, Taif 21944, Saudi Arabia.
EM k.alsolami@tu.edu.sa; Reham.z@tu.edu.sa
RI alsolami, khadeejah/HPD-4745-2023; Hamza, Reham/N-4030-2018
OI Hamza, Reham/0000-0001-7083-9467
FU Taif University, Saudi Arabia [TU-DSPP-2024-187]
FX This research was funded by Taif University, Saudi Arabia, ProjectNo.
   (TU-DSPP-2024-187).
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NR 52
TC 1
Z9 1
U1 0
U2 1
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 2045-452X
EI 2045-4538
J9 TOXICOL RES-UK
JI Toxicol. Res.
PD AUG 21
PY 2024
VL 13
IS 4
AR tfae135
DI 10.1093/toxres/tfae135
PG 10
WC Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Toxicology
GA D4Y2B
UT WOS:001296247400001
PM 39175812
DA 2025-06-11
ER

PT J
AU Rizos, CV
   Liberopoulos, EN
   Tellis, CC
   Tselepis, AD
   Elisaf, MS
AF Rizos, Christos V.
   Liberopoulos, Evangelos N.
   Tellis, Constantinos C.
   Tselepis, Alexandros D.
   Elisaf, Moses S.
TI The effect of combining rosuvastatin with sartans of different
   peroxisome proliferator receptor-γ activating capacity on plasma
   8-isoprostane prostaglandin F2a levels
SO ARCHIVES OF MEDICAL SCIENCE
LA English
DT Article
DE rosuvastatin; telmisartan; olmesartan; irbesartan; oxidative stress
ID VASCULAR OXIDATIVE STRESS; CORONARY-ARTERY-DISEASE; ANGIOTENSIN-II;
   OXIDASE EXPRESSION; METABOLIC SYNDROME; BLOOD-PRESSURE; RISK-FACTORS;
   IN-VIVO; HYPERTENSION; INFLAMMATION
AB Introduction: Oxidative stress is associated with the development and progression of cardiovascular disease. Plasma 8-isoprostane prostaglandin F-2a (8-iso-PGF(2a)) levels are a reliable marker of oxidative stress. Material and methods: Patients (n = 151) with hypertension, dyslipidemia and impaired fasting glucose were randomly allocated to rosuvastatin (10 mg/day) plus telmisartan 80 mg/day (RT group, n = 52) or irbesartan 300 mg/day (RI group, n = 48) or olmesartan 20 mg/day (RO group, n = 51). After 6 months of treatment, changes in plasma 8-iso-PGF(2a), levels were blindly evaluated. Results: A decrease of 8-iso-PGF(2a), levels vs baseline was observed only in the RT group (-8.6%; p = 0.02). A trend for decrease vs. baseline was observed in the RI (-5.7%; p = 0.40) and RO (-3.7%; p = 0.60) groups. Changes of 8-i50-PGF(2a), levels between groups were not significantly different (p = 0.70). Conclusions: The combination of rosuvastatin with sartans of different peroxisome proliferator receptor-gamma activating capacity was associated with a decrease in levels of plasma 8-i50-PGF2a. This decrease reached significance only in the telmisartan group.
C1 [Rizos, Christos V.; Liberopoulos, Evangelos N.; Elisaf, Moses S.] Univ Ioannina, Sch Med, Dept Internal Med, GR-45110 Ioannina, Greece.
   [Tellis, Constantinos C.; Tselepis, Alexandros D.] Univ Ioannina, Sch Chem, Biochem Lab, GR-45110 Ioannina, Greece.
C3 University of Ioannina; University of Ioannina
RP Elisaf, MS (corresponding author), Univ Ioannina, Sch Med, Dept Internal Med, GR-45110 Ioannina, Greece.
EM xristos10@gmail.com; egepi@cc.uoi.gr
RI Rizos, Christos/AAQ-5981-2020
OI Rizos, Christos/0000-0003-3495-9175; Liberopoulos,
   Evangelos/0000-0002-7162-3323; ELISAF, MOSES/0000-0003-0505-078X
CR Agouridis AP, 2011, EXPERT OPIN PHARMACO, V12, P2605, DOI 10.1517/14656566.2011.591383
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NR 24
TC 11
Z9 11
U1 0
U2 2
PU TERMEDIA PUBLISHING HOUSE LTD
PI POZNAN
PA KLEEBERGA ST 2, POZNAN, 61-615, POLAND
SN 1734-1922
EI 1896-9151
J9 ARCH MED SCI
JI Arch. Med. Sci.
PD FEB
PY 2013
VL 9
IS 1
BP 172
EP 176
DI 10.5114/aoms.2013.33357
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 102FJ
UT WOS:000315829900027
PM 23515108
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Wong, SK
   Chin, KY
   Ahmad, F
   Ima-Nirwana, S
AF Wong, Sok Kuan
   Chin, Kok-Yong
   Ahmad, Fairus
   Ima-Nirwana, Soelaiman
TI Biochemical and histopathological assessment of liver in a rat model of
   metabolic syndrome induced by high-carbohydrate high-fat diet
SO JOURNAL OF FOOD BIOCHEMISTRY
LA English
DT Article
DE antioxidants; lipid peroxidation; nonalcoholic fatty liver disease;
   oxidative stress; reactive oxygen species
ID OXIDATIVE STRESS
AB This study aimed to evaluate the oxidative stress status, antioxidants capacity, and presence of nonalcoholic fatty liver disease (NAFLD) in an animal model of MetS induced by high-carbohydrate high-fat (HCHF) diet. Male Wistar rats were randomized into two groups, assigned for two different types of diet (standard rat pellet or HCHF diet) for 20 weeks. Liver was excised, weighed, and subjected to lipid peroxidation, nitric oxide (NO center dot) production, antioxidants activity, and histological assessment. The HCHF rats had higher lipid peroxidation and NO center dot level but lower enzymatic and nonenzymatic antioxidant levels than the normal animals. Histological evaluation revealed higher lobular inflammation, hepatocellular ballooning, NAFLD activity score, and lipid accumulation in the liver of HCHF group. In conclusion, the HCHF diet causes an increase in oxidative stress, depletion of antioxidants capacity, NAFLD, and liver injury. The induction of oxidative stress may be partially responsible for the development of NAFLD in MetS. Practical applications The prevalence of MetS is estimated to increase rapidly with the escalating levels of obesity, diabetes, hypertension, and dyslipidemia. A suitable animal model of MetS that best mimicked the human disease state with known underlying mechanisms responsible for the pathogenesis of MetS is indispensable to search for potential adjunct therapies and drug targets. Thus, our current study elucidated the involvement of oxidative stress in linking MetS and NAFLD which might resemble the pathogenesis of MetS among Southeast Asian population.
C1 [Wong, Sok Kuan; Chin, Kok-Yong; Ima-Nirwana, Soelaiman] Univ Kebangsaan Malaysia, Fac Med, Dept Pharmacol, Jalan Yaacob Latif, Kuala Lumpur 56000, Malaysia.
   [Ahmad, Fairus] Univ Kebangsaan Malaysia, Fac Med, Dept Anat, Kuala Lumpur, Malaysia.
C3 Universiti Kebangsaan Malaysia; Universiti Kebangsaan Malaysia
RP Ima-Nirwana, S (corresponding author), Univ Kebangsaan Malaysia, Fac Med, Dept Pharmacol, Jalan Yaacob Latif, Kuala Lumpur 56000, Malaysia.
EM imasoel@yahoo.com
RI Soelaiman, Ima/C-4289-2017; Chin, Kok-Yong/B-6309-2015; Wong, Sok
   Kuan/I-1243-2016
OI Chin, Kok-Yong/0000-0001-6628-1552; Wong, Sok Kuan/0000-0003-1184-4551;
   Ahmad, Fairus/0000-0002-2452-6459
FU Universiti Kebangsaan Malaysia [MI-2019-006]; Ministry of Education
   Malaysia [FRGS/1/2018/SKK10/UKM/03/1]
FX Universiti Kebangsaan Malaysia, Grant/Award Number: MI-2019-006;
   Ministry of Education Malaysia, Grant/Award Number:
   FRGS/1/2018/SKK10/UKM/03/1
CR [Anonymous], 2019, INT J MOL SCI
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NR 41
TC 6
Z9 6
U1 0
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0145-8884
EI 1745-4514
J9 J FOOD BIOCHEM
JI J. Food Biochem.
PD OCT
PY 2020
VL 44
IS 10
AR e13371
DI 10.1111/jfbc.13371
EA AUG 2020
PG 9
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA OH3NS
UT WOS:000554539600001
PM 32744348
OA gold
DA 2025-06-11
ER

PT J
AU Szivak, TK
   Kraemer, WJ
AF Szivak, Tunde K.
   Kraemer, William J.
TI PHYSIOLOGICAL READINESS AND RESILIENCE: PILLARS OF MILITARY PREPAREDNESS
SO JOURNAL OF STRENGTH AND CONDITIONING RESEARCH
LA English
DT Article
DE stress; stress inoculation; adrenal; load carriage
ID HIGH-INTENSITY; EXERCISE; STRESS; RESPONSES; CONSEQUENCES; PERFORMANCE;
   DECREMENTS; HEALTH
AB Warfighters require a range of physical capabilities to meet the demands of the military profession, and physical training must address performance along an entire continuum, depending on individual needs and mission requirements. Strength and power capabilities are needed for optimal performance of anaerobic tasks such as heavy load carriage, sprinting under load, and maneuvering over uneven terrain. For optimal performance, soldiers must also be able to recover from mission demands and strenuous training. The demands placed on a soldier can result in a chronic stress, leading to decreased mission performance, increased injury risk, and increased susceptibility to illness. These factors are exacerbated by inappropriate training strategies such as overemphasis on endurance exercise combined with other stressors such as lack of sleep or inadequate nutrition. Chronic stress has been linked to overreaching/overtraining and to the development of comorbidities such as metabolic syndrome, insulin resistance, and hypertension and has adverse effects on memory and cognitive function. Resistance exercise is an effective method to improve warfighter physical performance and resilience to stress, thereby impacting mission readiness. Resistance exercise in particular confers many benefits to include increased strength and power, improved body composition, and protective effects on tendons, ligaments, and bone. Physically fit individuals not only benefit from improved mission performance but also are more resilient to operational stressors faced during combat. Ultimately, resilient soldiers are better able to cope with the physical and mental demands of the military profession and over the long term will perform better while maintaining health and well-being.
C1 [Szivak, Tunde K.; Kraemer, William J.] Ohio State Univ, Dept Human Sci, Coll Educ & Human Ecol, Columbus, OH 43210 USA.
C3 University System of Ohio; Ohio State University
RP Szivak, TK (corresponding author), Ohio State Univ, Dept Human Sci, Coll Educ & Human Ecol, Columbus, OH 43210 USA.
EM szivak.1@osu.edu
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NR 25
TC 49
Z9 55
U1 2
U2 29
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1064-8011
EI 1533-4287
J9 J STRENGTH COND RES
JI J. Strength Cond. Res.
PD NOV
PY 2015
VL 29
SU 11
BP S34
EP S39
DI 10.1519/JSC.0000000000001073
PG 6
WC Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Sport Sciences
GA DN5KB
UT WOS:000377104500006
PM 26506195
DA 2025-06-11
ER

PT J
AU Baur, DM
   Leiba, A
   Christophi, CA
   Kales, SN
AF Baur, D. M.
   Leiba, A.
   Christophi, C. A.
   Kales, S. N.
TI Low fitness is associated with exercise abnormalities among asymptomatic
   firefighters
SO OCCUPATIONAL MEDICINE-OXFORD
LA English
DT Article
DE Cardiovascular disease; epidemiology; exercise tests; stress tests
ID CARDIORESPIRATORY FITNESS; DISEASE
AB Background Low cardiorespiratory fitness (CRF) has been repeatedly linked to cardiovascular morbidity and mortality, while higher CRF levels are protective. This relationship is likely to be highly relevant in firefighters, who have increased risk of cardiovascular disease (CVD) mortality during strenuous emergencies, which can require prolonged periods of near-maximal heart rates (HR) and high workloads. Abnormalities during maximal stress testing could mark future CVD risk during strenuous duties.
   Aims To determine if low CRF among asymptomatic firefighters is associated with higher risk of electrocardiographic (ECG) and autonomic abnormalities during maximal exercise stress testing and recovery.
   Methods Male career firefighters completed a maximal stress test exercising to volitional exhaustion (mean maximal age-predicted HR achieved 98%, standard deviation (SD) = 6.5). CRF was measured as maximal metabolic equivalents (METS) achieved. Abnormal exercise tests included the following: abnormal HR recovery; chronotropic insufficiency; exaggerated blood pressure response; and ECG abnormalities. The relationship of CRF to stress testing abnormalities was analysed using peak METS categories and peak METS as a continuous variable after adjusting for age, body mass index (BMI) and metabolic syndrome (MetSyn).
   Results There were 1149 study participants. CRF was inversely associated with the risk of both ECG and autonomic exercise testing abnormalities before and after adjustment for age, BMI and MetSyn.
   Conclusions Firefighters with lower CRF are significantly more prone to exhibit abnormal stress test parameters, which may indicate higher future risk of cardiovascular events. As such, firefighters with low CRF (<= 12 METS) should receive cardiovascular risk reduction, including efforts to improve their CRF.
C1 [Baur, D. M.; Leiba, A.; Kales, S. N.] Harvard Univ, Sch Med, Cambridge Hlth Alliance, Cambridge, MA 02139 USA.
   [Baur, D. M.; Christophi, C. A.; Kales, S. N.] Harvard Univ, Sch Publ Hlth, Dept Environm Hlth Environm & Occupat Med & Epide, Cambridge, MA 02139 USA.
   [Leiba, A.] Chaim Sheba Med Ctr, Inst Nephrol & Hypertens, IL-52621 Tel Hashomer, Israel.
   [Christophi, C. A.] Cyprus Univ Technol, Harvard Sch Publ Hlth, Cyprus Int Inst Environm & Publ Hlth, Limassol, Cyprus.
C3 Harvard University; Harvard University Medical Affiliates; Cambridge
   Health Alliance; Harvard University; Harvard T.H. Chan School of Public
   Health; Chaim Sheba Medical Center; Cyprus International Institute for
   Environmental & Public Health; Cyprus University of Technology
RP Kales, SN (corresponding author), Harvard Univ, Sch Med, Cambridge Hlth Alliance, 1493 Cambridge St,Macht 427, Cambridge, MA 02139 USA.
EM skales@challiance.org
OI Christophi, Costas/0000-0003-0503-1538
FU Federal Emergency Management Agency (FEMA) (Washington DC, USA);
   Assistance to Firefighters Grant (AFG) [EMW-2006-FP-01493,
   EMW-2009-FP-00835, EMW-2007-FP-02197]
FX Federal Emergency Management Agency (FEMA) (Washington DC, USA);
   Assistance to Firefighters Grant (AFG) program's awards
   (EMW-2006-FP-01493 and EMW-2009-FP-00835 to S.N.K. and EMW-2007-FP-02197
   to C. A. Czeisler).
CR Arena R, 2010, FUTUR CARDIOL, V6, P325, DOI 10.2217/FCA.10.21
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   National Fire Protection Association, 2007, NFPA ASS 1582 STAND
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NR 10
TC 25
Z9 30
U1 0
U2 4
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0962-7480
J9 OCCUP MED-OXFORD
JI Occup. Med.-Oxf.
PD OCT
PY 2012
VL 62
IS 7
BP 566
EP 569
DI 10.1093/occmed/kqs112
PG 4
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA 024QR
UT WOS:000310124200019
PM 22826554
OA Bronze
DA 2025-06-11
ER

PT J
AU Tian, R
   Peng, R
   Yang, ZY
   Peng, YY
   Lu, NH
AF Tian, Rong
   Peng, Rou
   Yang, Ziyi
   Peng, Yi-Yuan
   Lu, Naihao
TI Supplementation of dietary nitrate attenuated oxidative stress and
   endothelial dysfunction in diabetic vasculature through inhibition of
   NADPH oxidase
SO NITRIC OXIDE-BIOLOGY AND CHEMISTRY
LA English
DT Article
DE Nitrate; Nitric oxide; NADPH oxidase; Endothelial dysfunction; Diabetes
ID NITRIC-OXIDE; INORGANIC NITRATE; HEME OXYGENASE-1; BLOOD-PRESSURE;
   SUPEROXIDE-PRODUCTION; PRIMARY TARGET; PATHOPHYSIOLOGY; INFLAMMATION;
   ANTIOXIDANT; METABOLISM
AB The metabolic disorders in diabetes, which are usually accompanied by oxidative stress and impaired nitric oxide (NO) bioavailability, increase the risk of detrimental cardiovascular complications. Herein, we investigated the therapeutic potential of dietary nitrate, which is found in high content in green leafy vegetables, on vascular oxidative stress and endothelial dysfunction in diabetic mice induced by high-fat diet and streptozotocin injection. Dietary nitrate in drinking water fuelled a nitrate-nitrite-NO pathway, which inhibited vascular oxidative stress, endothelial dysfunction and many features of metabolic syndrome in diabetic mice. These beneficial effects of nitrate on diabetic mice were abolished by PTIO (NO scavenger) treatment and significantly prevented by febuxostat (xanthine oxidoreductase inhibitor), demonstrating the central importance of NO in bioactivation of nitrate. The favorable effects of nitrate were not further influenced by apocynin (NADPH oxidase inhibitor), suggesting NADPH oxidase as a possible target. In high glucose-incubated vascular endothelial cells, NO donor attenuated oxidative stress and endothelial dysfunction via the inhibition of NADPH oxidase, where a heme oxygenase-1 (HO-1)-dependent mechanism was demonstrated for the antioxidant abilities of NO. Altogether, boosting this nitrate-nitrite-NO signaling pathway resulted in the decreases of NADPH oxidasederived oxidative stress, endothelial dysfunction and metabolic disorders in diabetic vasculature. These findings may have novel implications for the preventive strategy against diabetes-induced vascular dysfunction and associated complications.
C1 [Tian, Rong; Peng, Rou; Yang, Ziyi; Peng, Yi-Yuan; Lu, Naihao] Jiangxi Normal Univ, Jiangxi Prov & Coll Chem & Chem Engn, Key Lab Green Chem, Key Lab Funct Small Organ Mol,Minist Educ, Nanchang, Jiangxi, Peoples R China.
C3 Jiangxi Normal University; Ministry of Education - China
RP Peng, YY; Lu, NH (corresponding author), Jiangxi Normal Univ, Jiangxi Prov & Coll Chem & Chem Engn, Key Lab Green Chem, Key Lab Funct Small Organ Mol,Minist Educ, Nanchang, Jiangxi, Peoples R China.
EM yiyuanpeng@yahoo.com; naihaolu@jxnu.edu.cn
RI yang, ziyi/JGD-5349-2023
FU National Natural Science Foundation of China [31960196, 31760255,
   31560255, 31260216]; Natural Science Foundation of Jiangxi Province
   [20171BCB23041, 20161BAB215215]; Graduate Innovation Fund Project of
   Jiangxi Province [YC2018-B030]; Open Project Program of Key Laboratory
   of Functional Small Organic Molecule, Ministry of Education, Jiangxi
   Normal University [KLFS-KF-201923]
FX Financial support from the National Natural Science Foundation of China
   (Nos. 31960196, 31760255, 31560255, 31260216), the Natural Science
   Foundation of Jiangxi Province (No. 20171BCB23041, 20161BAB215215), the
   Graduate Innovation Fund Project of Jiangxi Province (No. YC2018-B030)
   and the Open Project Program of Key Laboratory of Functional Small
   Organic Molecule, Ministry of Education, Jiangxi Normal University (No.
   KLFS-KF-201923).
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NR 44
TC 25
Z9 26
U1 0
U2 13
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 1089-8603
EI 1089-8611
J9 NITRIC OXIDE-BIOL CH
JI Nitric Oxide-Biol. Chem.
PD MAR 1
PY 2020
VL 96
BP 54
EP 63
DI 10.1016/j.niox.2020.01.007
PG 10
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA KK0YV
UT WOS:000512478200007
PM 31972252
DA 2025-06-11
ER

PT J
AU Vlassara, H
   Striker, GE
AF Vlassara, Helen
   Striker, Gary E.
TI AGE restriction in diabetes mellitus: a paradigm shift
SO NATURE REVIEWS ENDOCRINOLOGY
LA English
DT Review
ID GLYCATION END-PRODUCTS; GLUCOSE-MODIFIED PROTEINS;
   LOW-DENSITY-LIPOPROTEIN; REGULATORY T-CELLS; OXIDATIVE-STRESS; ADVANCED
   GLYCOSYLATION; OXIDANT STRESS; INSULIN-RESISTANCE; DIETARY GLYCOTOXINS;
   METABOLIC SYNDROME
AB Persistently elevated oxidative stress and inflammation precede or occur during the development of type 1 or type 2 diabetes mellitus and precipitate devastating complications. Given the rapidly increasing incidence of diabetes mellitus and obesity in the space of a few decades, new genetic mutations are unlikely to be the cause, instead pointing to environmental initiators. A hallmark of contemporary culture is a preference for thermally processed foods, replete with pro-oxidant advanced glycation endproducts (AGEs). These molecules are appetite-increasing and, thus, efficient enhancers of overnutrition (which promotes obesity) and oxidant overload (which promotes inflammation). Studies of genetic and nongenetic animal models of diabetes mellitus suggest that suppression of host defenses, under sustained pressure from food-derived AGEs, may potentially shift homeostasis towards a higher basal level of oxidative stress, inflammation and injury of both insulin-producing and insulin-responsive cells. This sequence promotes both types of diabetes mellitus. Reducing basal oxidative stress by AGE restriction in mice, without energy or nutrient change, reinstates host defenses, alleviates inflammation, prevents diabetes mellitus, vascular and renal complications and extends normal lifespan. Studies in healthy humans and in those with diabetes mellitus show that consumption of high amounts of food-related AGEs is a determinant of insulin resistance and inflammation and that AGE restriction improves both. This Review focuses on AGEs as novel initiators of oxidative stress that precedes, rather than results from, diabetes mellitus. Therapeutic gains from AGE restriction constitute a paradigm shift.
C1 [Vlassara, Helen; Striker, Gary E.] Mt Sinai Sch Med, Div Expt Diabet & Aging, Brookdale Dept Geriatr, New York, NY 10029 USA.
C3 Icahn School of Medicine at Mount Sinai
RP Vlassara, H (corresponding author), Mt Sinai Sch Med, Div Expt Diabet & Aging, Brookdale Dept Geriatr, 1 Gustave L Levy Pl,Box 1460, New York, NY 10029 USA.
EM helen.vlassara@mssm.edu
FU MERIT [AG-23, 188, AG-09, 453, DK091231, RR-00071]
FX Work described in this Review was supported in part by MERIT grant
   AG-23,188, AG-09,453 and DK091231 (H. Vlassara) and RR-00071.
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NR 177
TC 216
Z9 235
U1 0
U2 38
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 1759-5029
EI 1759-5037
J9 NAT REV ENDOCRINOL
JI Nat. Rev. Endocrinol.
PD SEP
PY 2011
VL 7
IS 9
BP 526
EP 539
DI 10.1038/nrendo.2011.74
PG 14
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 810FL
UT WOS:000294111000008
PM 21610689
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Hodgson, JM
   Watts, GF
AF Hodgson, JM
   Watts, GF
TI Can coenzyme Q10 improve vascular function and blood
   pressure?: Potential for effective therapeutic reduction in vascular
   oxidative stress
SO BIOFACTORS
LA English
DT Article; Proceedings Paper
CT 3rd Conference of the International Coenzyme Q10 Association
CY NOV 22-24, 2002
CL LONDON, ENGLAND
DE coenzyme Q(10); vascular function; endothelial function; blood pressure;
   oxidative stress; nitrosative stress
ID NITRIC-OXIDE; DIABETES-MELLITUS; ENDOTHELIAL DYSFUNCTION; HYPERTENSION;
   ARTERY; ATHEROSCLEROSIS; PEROXYNITRITE; ANTIOXIDANTS; RESISTANCE;
   MECHANISM
AB Coenzyme Q(10) (CoQ) is an endogenously synthesised compound that acts as an electron carrier in the mitochondrial electron transport chain. The presence of adequate tissue concentrations of CoQ may be important in limiting oxidative and nitrosative damage in vivo. Oxidative and nitrosative stress are likely to be elevated in conditions such as diabetes and hypertension. In these conditions elevated oxidative and nitrosative stress within the arterial wall may contribute to increased blood pressure and vascular dysfunction. The major focus of this review is the potential of CoQ to improve vascular function and lower blood pressure. Although there is substantial indirect support for the putative mechanism of effect of CoQ on the vascular system, to date there is little direct support for an effect of CoQ on in vivo markers of oxidative or nitrosative stress. The limited data available from studies in animal models and from human intervention studies are generally consistent with a benefit of CoQ on vascular function and blood pressure. The observed effects of CoQ on these endpoints are potentially important therapeutically. However, before any firm clinical recommendations can be made about CoQ supplementation, further intervention studies in humans are needed to investigate the effects of CoQ on vascular function, blood pressure and cardiovascular outcomes. The particularly relevant groups of patients for these studies are those with insulin resistance, type 2 diabetes, hypertension and the metabolic syndrome.
C1 Univ Western Australia, Sch Med & Pharmacol, Perth, WA 6847, Australia.
   Royal Perth Hosp, Med Res Inst, Perth, WA, Australia.
C3 University of Western Australia; East Metropolitan Health Service; Royal
   Perth Hospital; University of Western Australia
RP Univ Western Australia, Sch Med & Pharmacol, GPO Box X2213, Perth, WA 6847, Australia.
EM gfwatts@cyllene.uwa.edu.au
RI Watts, Gerald/HII-8530-2022
OI Watts, Gerald/0000-0003-2276-1524; Hodgson, Jonathan/0000-0001-6184-7764
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NR 45
TC 26
Z9 27
U1 1
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0951-6433
EI 1872-8081
J9 BIOFACTORS
JI Biofactors
PY 2003
VL 18
IS 1-4
SI SI
BP 129
EP 136
DI 10.1002/biof.5520180215
PG 8
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 764AC
UT WOS:000188166700015
PM 14695928
DA 2025-06-11
ER

PT J
AU Lim, S
   Taskinen, MR
   Borén, J
AF Lim, Soo
   Taskinen, Marja-Riitta
   Boren, Jan
TI Crosstalk between nonalcoholic fatty liver disease and cardiometabolic
   syndrome
SO OBESITY REVIEWS
LA English
DT Article
DE cardiometabolic syndrome; nonalcoholic fatty liver disease;
   inflammation; oxidative stress
ID HEPATIC INSULIN-RESISTANCE; ENDOPLASMIC-RETICULUM STRESS; C-REACTIVE
   PROTEIN; TERM-FOLLOW-UP; METABOLIC SYNDROME; OXIDATIVE STRESS; GUT
   MICROBIOTA; CARDIOVASCULAR-DISEASE; ALANINE AMINOTRANSFERASE;
   RISK-FACTORS
AB Nonalcoholic fatty liver disease (NAFLD) is a chronic condition characterized by fat accumulation combined with low-grade inflammation in the liver. A large body of clinical and experimental data shows that increased flux of free fatty acids from increased visceral adipose tissue and de novo lipogenesis can lead to NAFLD and insulin resistance. Thus, individuals with obesity, insulin resistance, and dyslipidaemia are at the greatest risk of developing NAFLD. Conversely, NAFLD is a phenotype of cardiometabolic syndrome. Notably, researchers have discovered a close association between NAFLD and impaired glucose metabolism and focused on the role of NAFLD in the development of type 2 diabetes. Moreover, recent studies provide substantial evidence for an association between NAFLD and atherosclerosis and cardiometabolic disorders. Even if NAFLD can progress into severe liver disorders including nonalcoholic steatohepatitis (NASH) and cirrhosis, the majority of subjects with NAFLD die from cardiovascular disease eventually. In this review, we propose a potential pathological link between NAFLD/NASH and cardiometabolic syndrome. The potential factors that can play a pivotal role in this link, such as inflammation, insulin resistance, alteration in lipid metabolism, oxidative stress, genetic predisposition, and gut microbiota are discussed.
C1 [Lim, Soo] Seoul Natl Univ, Coll Med, Dept Internal Med, Seongnam, South Korea.
   [Lim, Soo] Seoul Natl Univ, Bundang Hosp, Seongnam, South Korea.
   [Taskinen, Marja-Riitta] Univ Helsinki, Heart & Lung Ctr, Helsinki Univ Cent Hosp, Helsinki, Finland.
   [Taskinen, Marja-Riitta] Univ Helsinki, Res Programs Unit, Helsinki, Finland.
   [Boren, Jan] Univ Gothenburg, Dept Mol & Clin Med, Wallenberg Lab, Gothenburg, Sweden.
   [Boren, Jan] Sahlgrens Univ Hosp, Gothenburg, Sweden.
C3 Seoul National University (SNU); Seoul National University (SNU);
   University of Helsinki; Helsinki University Central Hospital; University
   of Helsinki; University of Gothenburg; Sahlgrenska University Hospital
RP Lim, S (corresponding author), Seoul Natl Univ, Coll Med, Endocrinol & Metab, 82,Gumi Ro 173 Beon Gil, Seongnam, South Korea.; Lim, S (corresponding author), Seoul Natl Univ, Bundang Hosp, 82,Gumi Ro 173 Beon Gil, Seongnam 13620, South Korea.
EM limsoo@snu.ac.kr
RI Lim, Soo/AAU-8107-2020; Taskinen, Marja-Riitta/AAN-5432-2020
OI Boren, Jan/0000-0003-0786-8091; Lim, Soo/0000-0002-4137-1671; Taskinen,
   Marja-Riitta/0000-0002-6229-3588
FU Seoul National University Bundang Hospital; Korean Society for the Study
   of Obesity
FX Seoul National University Bundang Hospital; Korean Society for the Study
   of Obesity
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NR 170
TC 64
Z9 66
U1 3
U2 37
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1467-7881
EI 1467-789X
J9 OBES REV
JI Obes. Rev.
PD APR
PY 2019
VL 20
IS 4
BP 599
EP 611
DI 10.1111/obr.12820
PG 13
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA HO8PW
UT WOS:000461218400008
PM 30589487
DA 2025-06-11
ER

PT J
AU Yzydorczyk, C
   Li, N
   Chehade, H
   Mosig, D
   Bidho, M
   Keshavjee, B
   Armengaud, JB
   Nardou, K
   Siddeek, B
   Benahmed, M
   Vergely, C
   Simeoni, U
AF Yzydorczyk, Catherine
   Li, Na
   Chehade, Hassib
   Mosig, Dolores
   Bidho, Mickael
   Keshavjee, Basile
   Armengaud, Jean Baptiste
   Nardou, Katya
   Siddeek, Benazir
   Benahmed, Mohamed
   Vergely, Catherine
   Simeoni, Umberto
TI Transient postnatal overfeeding causes liver stress-induced premature
   senescence in adult mice
SO SCIENTIFIC REPORTS
LA English
DT Article
ID HIGH-FAT DIET; INSULIN-RESISTANCE; OXIDATIVE STRESS; ADIPOSE-TISSUE;
   EARLY OVERNUTRITION; METABOLIC SYNDROME; CHRONIC HEPATITIS; RATS LEADS;
   OVERWEIGHT; EXPRESSION
AB Unbalanced nutrition early in life is increasingly recognized as an important factor in the development of chronic, non-communicable diseases at adulthood, including metabolic diseases. We aimed to determine whether transient postnatal overfeeding (OF) leads to liver stress-induced premature senescence (SIPS) of hepatocytes in association with liver structure and hepatic function alterations. Litters sizes of male C57BL/6 mice were adjusted to 9 pups (normal feeding, NF) or reduced to 3 pups during the lactation period to induce transient postnatal OF. Compared to the NF group, seven-monthold adult mice transiently overfed during the postnatal period were overweight and developed glucose intolerance and insulin resistance. Their livers showed microsteatosis and fibrosis, while hepatic insulin signaling and glucose transporter protein expressions were altered. Increased hepatic oxidative stress (OS) was observed, with increased superoxide anion production, glucose-6-phosphate dehydrogenase protein expression, oxidative DNA damage and decreased levels of antioxidant defense markers, such as superoxide dismutase and catalase proteins. Hepatocyte senescence was characterized by increased p21(WAF), p53, Acp53, p16(INK4a) and decreased pRb/Rb and Sirtuin-1 (SIRT-1) protein expression levels. Transient postnatal OF induces liver OS at adulthood, associated with hepatocyte SIPS and alterations in liver structure and hepatic functions, which could be mediated by a SIRT-1 deficiency.
C1 [Yzydorczyk, Catherine; Chehade, Hassib; Mosig, Dolores; Bidho, Mickael; Keshavjee, Basile; Armengaud, Jean Baptiste; Nardou, Katya; Siddeek, Benazir; Benahmed, Mohamed; Simeoni, Umberto] CHU Vaudois, Woman Mother Child Dept, Div Pediat, DOHaD Lab, Lausanne, Switzerland.
   [Yzydorczyk, Catherine; Chehade, Hassib; Mosig, Dolores; Bidho, Mickael; Keshavjee, Basile; Armengaud, Jean Baptiste; Nardou, Katya; Siddeek, Benazir; Benahmed, Mohamed; Simeoni, Umberto] Univ Lausanne, Lausanne, Switzerland.
   [Li, Na; Vergely, Catherine] Univ Bourgogne Franche Comte, UFR Sci Sante, Equipe Physiopathol & Epidemiol Cerebro Cardiovas, Dijon, France.
C3 University of Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV);
   University of Lausanne; Universite Bourgogne Europe
RP Yzydorczyk, C (corresponding author), CHU Vaudois, Woman Mother Child Dept, Div Pediat, DOHaD Lab, Lausanne, Switzerland.; Yzydorczyk, C (corresponding author), Univ Lausanne, Lausanne, Switzerland.
EM catherine.yzydorczyk@chuv.ch
RI SIMEONI, Umberto/AAQ-1870-2021; Simeoni, Umberto/GRO-6971-2022; VERGELY,
   CATHERINE/L-9534-2015
OI YZYDORCZYK, Catherine/0000-0002-0617-7558; Simeoni,
   Umberto/0000-0003-0730-9337; VERGELY, CATHERINE/0000-0003-4009-776X;
   SIDDEEK, Benazir/0000-0003-2764-6656; Chehade,
   Hassib/0000-0001-5019-2547
FU French Ministry of Research; Institut National de la Sante et de la
   Recherche Medicale (INSERM); CHUV-University of Lausanne, Switzerland
FX The authors gratefully thank the Mouse Pathology Institute, Prof
   Christine Sempoux, Dr. Anne Christine Peyter and Prof. Pedrazzini's lab
   at CHUV/UNIL for the provided technical assistance. This work was
   supported by grants from the French Ministry of Research and the
   Institut National de la Sante et de la Recherche Medicale (INSERM), and
   CHUV-University of Lausanne, Switzerland.
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NR 70
TC 17
Z9 18
U1 0
U2 7
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD OCT 10
PY 2017
VL 7
AR 12911
DI 10.1038/s41598-017-11756-2
PG 16
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA FJ3SE
UT WOS:000412651300016
PM 29018245
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Giusti, L
   Gabriele, M
   Penno, G
   Garofolo, M
   Longo, V
   Del Prato, S
   Lucchesi, D
   Pucci, L
AF Giusti, Laura
   Gabriele, Morena
   Penno, Giuseppe
   Garofolo, Monia
   Longo, Vincenzo
   Del Prato, Stefano
   Lucchesi, Daniela
   Pucci, Laura
TI A Fermented Whole Grain Prevents Lipopolysaccharides-Induced Dysfunction
   in Human Endothelial Progenitor Cells
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Article
ID NF-KAPPA-B; ENDOPLASMIC-RETICULUM STRESS; PRO-INFLAMMATORY RESPONSE;
   CROSS-TALK; OXIDATIVE STRESS; GUT MICROBIOTA; ER STRESS; LISOSAN G;
   NRF2; PROSTACYCLIN
AB Endogenous and exogenous signals derived by the gut microbiota such as lipopolysaccharides (LPS) orchestrate inflammatory responses contributing to development of the endothelial dysfunction associated with atherosclerosis in obesity, metabolic syndrome, and diabetes. Endothelial progenitor cells (EPCs), bone marrow derived stem cells, promote recovery of damaged endothelium playing a pivotal role in cardiovascular repair. Since healthy nutrition improves EPCs functions, we evaluated the effect of a fermented grain, Lisosan G (LG), on early EPCs exposed to LPS. The potential protective effect of LG against LPS-induced alterations was evaluated as cell viability, adhesiveness, ROS production, gene expression, and NF-kB signaling pathway activation. Our results showed that LPS treatment did not affect EPCs viability and adhesiveness but induced endothelial alterations via activation of NF-kB signaling. LG protects EPCs from inflammation as well as from LPS-induced oxidative and endoplasmic reticulum (ER) stress reducing ROS levels, downregulating proinflammatory and proapoptotic factors, and strengthening antioxidant defense. Moreover, LG pretreatment prevented NF-kB translocation from the cytoplasm into the nucleus caused by LPS exposure. In human EPCs, LPS increases ROS and upregulates proinflammatory tone, proapoptotic factors, and antioxidants. LG protects EPCs exposed to LPS reducing ROS, downregulating proinflammatory and proapoptotic factors, and strengthening antioxidant defenses possibly by inhibiting NF-kB nuclear translocation.
C1 [Giusti, Laura; Penno, Giuseppe; Garofolo, Monia; Del Prato, Stefano; Lucchesi, Daniela] Univ Pisana, Dept Clin & Expt Med, Sect Diabet & Metab Dis, Via Paradisa 2, I-56124 Pisa, Italy.
   [Giusti, Laura; Penno, Giuseppe; Garofolo, Monia; Del Prato, Stefano; Lucchesi, Daniela] Univ Pisana, Azienda Osped, Via Paradisa 2, I-56124 Pisa, Italy.
   [Gabriele, Morena; Longo, Vincenzo; Pucci, Laura] Inst Biol & Agr Biotechnol IBBA, Natl Res Council, Pisa Unit, Res Area Pisa, Via Moruzzi 1, I-56124 Pisa, Italy.
C3 University of Pisa; University of Pisa; Azienda Ospedaliero
   Universitaria Pisana; Consiglio Nazionale delle Ricerche (CNR); Istituto
   di Biologia e Biotecnologia Agraria (IBBA-CNR)
RP Longo, V (corresponding author), Inst Biol & Agr Biotechnol IBBA, Natl Res Council, Pisa Unit, Res Area Pisa, Via Moruzzi 1, I-56124 Pisa, Italy.
EM v.longo@ibba.cnr.it
RI Pucci, Laura/AAU-4653-2020; Del+Prato, Stefano/AAC-9197-2021; Longo,
   Vincenzo/K-3695-2018; Garofolo, Monia/J-7530-2018; Gabriele,
   Morena/L-1631-2018
OI Longo, Vincenzo/0000-0001-8972-8564; Pucci, Laura/0000-0001-7063-6192;
   Garofolo, Monia/0000-0002-2518-3187; Penno,
   Giuseppe/0000-0002-2834-4847; Gabriele, Morena/0000-0002-9456-6755
FU Regione Toscana, Italy [1157, D55E11002680005]
FX This work was supported by two grants from Regione Toscana, Italy: (1)
   NUTRA-TOSCAFRICA "Sviluppo di alimenti funzionali a partire dalla
   tradizione TOSCana e dell'AFRICA sub-sahariana: studio delle componenti
   NUTRA-ceutiche," research project 2015-2016; (2) "Endothelial injury and
   repair in diabetes. The development of a non-invasive multimarker index
   for 'vascular competence,'" Resolution 1157 (December 19, 2011), ID
   number D55E11002680005.
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NR 49
TC 39
Z9 42
U1 1
U2 15
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PY 2017
VL 2017
AR 1026268
DI 10.1155/2017/1026268
PG 13
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA EQ6ZO
UT WOS:000398232500001
PM 28386305
OA Green Published, hybrid, Green Submitted
DA 2025-06-11
ER

PT J
AU Hayden, MR
   Habibi, J
   Joginpally, T
   Karuparthi, PR
   Sowers, JR
AF Hayden, Melvin R.
   Habibi, Javad
   Joginpally, Tejaswini
   Karuparthi, Poorna R.
   Sowers, James R.
TI Ultrastructure Study of Transgenic Ren2 Rat Aorta - Part 1: Endothelium
   and Intima
SO CARDIORENAL MEDICINE
LA English
DT Article
DE Angiotensin II; Extracellular matrix remodeling; Hypertension; Intima;
   NADPH oxidase; Oxidative stress; Type 2 diabetes mellitus
ID WEIBEL-PALADE BODIES; OXIDATIVE STRESS; INSULIN-RESISTANCE;
   BETA-CATENIN; HYPERTENSION; OXIDASE; CADHERIN; CELLS; CONTRIBUTES;
   PLAKOGLOBIN
AB Background: The renin-angiotensin-aldosterone system plays an important role in the development and progression of hypertension and accelerated atherosclerosis (atheroscleropathy) associated with the cardiorenal metabolic syndrome and type 2 diabetes mellitus. Additionally, the renin-angiotensin-aldosterone system plays an important role in vascular-endothelial-intimal cellular and extracellular remodeling. Methods: Thoracic aortas of young male transgenic heterozygous (mRen2)27 (Ren2) rats were utilized for this ultrastructural study. This lean model of hypertension, insulin resistance and oxidative stress harbors the mouse renin gene with increased local tissue (aortic) levels of angiotensin II and angiotensin type 1 receptors and elevated plasma aldosterone levels. Results:The ultrastructural observations included marked endothelial cell retraction, separation, terminal nuclear lifting, adjacent duplication, apoptosis and a suggestion of endothelial progenitor cell attachment. The endothelium demonstrated increased caveolae, microparticles, depletion of Weibel-Palade bodies, loss of cell-cell and basal adhesion hemidesmosome-like structures, platelet adhesion and genesis of subendothelial neointima. Conclusion: These observational ultrastructural studies of the transgenic Ren2 vasculature provide an in-depth evaluation of early abnormal remodeling changes within conduit-elastic arteries under conditions of increased local levels of angiotensin II, oxidative stress, insulin resistance and hypertension. Copyright (C) 2012 S. Karger AG, Basel
C1 [Hayden, Melvin R.] Univ Missouri, Sch Med, Hlth Sci Ctr, Dept Internal Med, Columbia, MO 65212 USA.
   [Hayden, Melvin R.; Habibi, Javad; Sowers, James R.] Univ Missouri, Sch Med, Dept Diabet Endocrinol & Metab, Columbia, MO 65212 USA.
   [Karuparthi, Poorna R.] Univ Missouri, Sch Med, Dept Cardiovasc Dis, Columbia, MO 65212 USA.
   [Sowers, James R.] Univ Missouri, Sch Med, Dept Med Physiol & Pharmacol, Columbia, MO 65212 USA.
   [Hayden, Melvin R.; Habibi, Javad; Joginpally, Tejaswini; Sowers, James R.] Univ Missouri, Sch Med, Diabet & Cardiovasc Dis Ctr, Columbia, MO 65212 USA.
   [Habibi, Javad; Sowers, James R.] Harry S Truman VA Med Ctr, Columbia, MO USA.
C3 University of Missouri System; University of Missouri Columbia;
   University of Missouri System; University of Missouri Columbia;
   University of Missouri System; University of Missouri Columbia;
   University of Missouri System; University of Missouri Columbia;
   University of Missouri System; University of Missouri Columbia; US
   Department of Veterans Affairs; Veterans Health Administration (VHA);
   Harry S. Truman Memorial Veterans' Hospital
RP Hayden, MR (corresponding author), Univ Missouri, Sch Med, Hlth Sci Ctr, Dept Internal Med, MA410,DC043-00, Columbia, MO 65212 USA.
EM mrh29@usmo.com
FU NIH [R01 HL73101-01A1]; Veterans Affairs Merit System [0018]
FX The authors would like to acknowledge the Electron Microscopic Core
   Center at the University of Missouri, Columbia, Mo., USA, for the
   preparation of animal tissue samples for viewing. We also acknowledge
   Brenda Hunter for her assistance in preparing the manuscript. This
   research was supported by NIH (R01 HL73101-01A1) and the Veterans
   Affairs Merit System (0018).
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NR 45
TC 9
Z9 10
U1 0
U2 5
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1664-3828
EI 1664-5502
J9 CARDIORENAL MED
JI CardioRenal Med.
PY 2012
VL 2
IS 1
BP 66
EP 82
DI 10.1159/000335565
PG 17
WC Cardiac & Cardiovascular Systems; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Urology & Nephrology
GA 051ZO
UT WOS:000312167700009
PM 22493605
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Zhou, YK
   Qian, C
   Tang, Y
   Song, MY
   Zhang, T
   Dong, GL
   Zheng, WW
   Yang, CM
   Zhong, CJ
   Wang, AY
   Zhao, Y
   Lu, Y
AF Zhou, Yueke
   Qian, Cheng
   Tang, Yu
   Song, Mengyao
   Zhang, Teng
   Dong, Guanglu
   Zheng, Weiwei
   Yang, Chunmei
   Zhong, Chongjin
   Wang, Aiyun
   Zhao, Yang
   Lu, Yin
TI Advance in the pharmacological effects of quercetin in modulating
   oxidative stress and inflammation related disorders
SO PHYTOTHERAPY RESEARCH
LA English
DT Review
DE cancer; cardiovascular disease; flavonoids; inflammation;
   neurodegeneration; oxidative stress; quercetin
ID TYPE-2 DIABETES-MELLITUS; TISSUE DISTRIBUTION; ACUTE-PANCREATITIS;
   IN-VIVO; CANCER; GLUTATHIONE; DISEASE; PATHOPHYSIOLOGY; PATHOGENESIS;
   MECHANISM
AB Numerous pharmacological effects of quercetin have been illustrated, including antiinflammation, antioxidation, and anticancer properties. In recent years, the antioxidant activity of quercetin has been extensively reported, in particular, its impacts on glutathione, enzyme activity, signaling transduction pathways, and reactive oxygen species (ROS). Quercetin has also been demonstrated to exert a striking antiinflammatory effect mainly by inhibiting the production of cytokines, reducing the expression of cyclooxygenase and lipoxygenase, and preserving the integrity of mast cells. By regulating oxidative stress and inflammation, which are regarded as two critical processes involved in the defense and regular physiological operation of biological systems, quercetin has been validated to be effective in treating a variety of disorders. Symptoms of these reactions have been linked to degenerative processes and metabolic disorders, including metabolic syndrome, cardiovascular, neurodegeneration, cancer, and nonalcoholic fatty liver disease. Despite that evidence demonstrates that antioxidants are employed to prevent excessive oxidative and inflammatory processes, there are still concerns regarding the expense, accessibility, and side effects of agents. Notably, natural products, especially those derived from plants, are widely accessible, affordable, and generally safe. In this review, the antioxidant and antiinflammatory abilities of the active ingredient quercetin and its application in oxidative stress-related disorders have been outlined in detail.
C1 [Zhou, Yueke; Qian, Cheng; Tang, Yu; Song, Mengyao; Zhang, Teng; Zheng, Weiwei; Yang, Chunmei; Zhong, Chongjin; Wang, Aiyun; Zhao, Yang; Lu, Yin] Nanjing Univ Chinese Med, Sch Pharm, Jiangsu Key Lab Pharmacol & Safety Evaluat Chinese, Nanjing 210023, Peoples R China.
   [Qian, Cheng; Dong, Guanglu; Zheng, Weiwei; Yang, Chunmei; Zhong, Chongjin; Zhao, Yang] Nanjing Univ Chinese Med, Sch Med & Holist Integrat Med, Dept Biochem & Mol Biol, Nanjing 210023, Peoples R China.
   [Wang, Aiyun; Lu, Yin] Nanjing Univ Chinese Med, Jiangsu Joint Int Res Lab Chinese Med & Regenerat, Nanjing, Peoples R China.
C3 Nanjing University of Chinese Medicine; Nanjing University of Chinese
   Medicine; Nanjing University of Chinese Medicine
RP Wang, AY; Zhao, Y; Lu, Y (corresponding author), Nanjing Univ Chinese Med, Sch Pharm, Jiangsu Key Lab Pharmacol & Safety Evaluat Chinese, Nanjing 210023, Peoples R China.; Zhao, Y (corresponding author), Nanjing Univ Chinese Med, Sch Med & Holist Integrat Med, Dept Biochem & Mol Biol, Nanjing 210023, Peoples R China.
EM wangaiyun@njucm.edu.cn; y.zhao@njucm.edu.cn; luyingreen@njucm.edu.cn
RI Yang, Chunmei/IXX-2014-2023; wang, aiyun/KBB-4469-2024
OI qian, cheng/0000-0001-9852-2285; wang, aiyun/0000-0002-4745-7302
FU Jiangsu Specially Appointed Professorship Foundation [013038021001];
   Jiangsu Province Traditional Chinese Medicine Leading Talents Program
   [SLJ0229]
FX ACKNOWLEDGMENTS This project was supported by Jiangsu Specially
   Appointed Professorship Foundation (013038021001) and Jiangsu Province
   Traditional Chinese Medicine Leading Talents Program (SLJ0229). The
   authors thank the members of Yin Lu laboratory for productive
   discussions.
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NR 187
TC 32
Z9 35
U1 12
U2 50
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0951-418X
EI 1099-1573
J9 PHYTOTHER RES
JI Phytother. Res.
PD NOV
PY 2023
VL 37
IS 11
BP 4999
EP 5016
DI 10.1002/ptr.7966
EA JUL 2023
PG 18
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA Y0PL2
UT WOS:001032829600001
PM 37491826
OA Bronze
DA 2025-06-11
ER

PT J
AU Arslanbulut, G
   Çiftçi, S
AF Arslanbulut, Gozde
   Ciftci, Seda
TI Exploring the link between fructose intake and Non-Alcoholic Fatty Liver
   Disease (NAFLD)
SO CAHIERS DE NUTRITION ET DE DIETETIQUE
LA English
DT Article
DE Fructose; Non-alcoholic fatty liver disease; Dietary sugar intake
ID ENDOPLASMIC-RETICULUM STRESS; HEPATIC STEATOSIS; OXIDATIVE STRESS;
   AMINO-ACIDS; URIC-ACID; STEATOHEPATITIS; PATHOGENESIS; SUGAR;
   EPIDEMIOLOGY; LIPOTOXICITY
AB The metabolic syndrome's hepatic form, Non-Alcoholic Fatty Liver Disease (NAFLD), is becoming more common at the same time that obesity and diabetes are rising. A fatty liver and the buildup of 5% fat are characteristics of NAFLD with the absence of any secondary cause. Fatty acid intake increases into the liver, very low-density lipoprotein lowers the transport of TGs through the liver, free fatty acid oxidation decreases, and de novo lipogenesis increases in the liver - these are the four processes by which fatty liver develops. Factors that cause the pathogenesis of NAFLD include a modern, unhealthy lifestyle. Honey, fruit, commercially produced high-fructose corn syrup and many vegetables contains fructose as a monosaccharide. Sorbitol common in many vegetables and fruits is converted to fructose through reaction of sorbitol dehydrogenase in liver. Although end products of fructose catabolism are like those of glucose, after digestion, fructose does not cause the hormonal reaction that glucose does, and metabolism regulation is different. In this review, fructose is highlighted because it has been shown to have an impact on the pathogenesis of NAFLD by causing the buildup of visceral fatty tissue, the emergence of insulin resistance, endoplasmic reticulum stress, inflammation, and oxidative stress.
C1 [Arslanbulut, Gozde; Ciftci, Seda] Izmir Democracy Univ, Hlth Sci Fac, Nutr & Dietet, Izmir, Turkiye.
C3 Izmir Democracy University
RP Çiftçi, S (corresponding author), Izmir Democracy Univ, Hlth Sci Fac, Nutr & Dietet, Izmir, Turkiye.
EM dytsedaciftci@gmail.com
RI ciftci, seda/HPH-3407-2023
OI Ciftci, Seda/0000-0002-4103-1618; Arslanbulut, Gozde/0009-0002-0835-0526
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NR 92
TC 0
Z9 0
U1 4
U2 10
PU MASSON EDITEUR
PI MOULINEAUX CEDEX 9
PA 21 STREET CAMILLE DESMOULINS, ISSY, 92789 MOULINEAUX CEDEX 9, FRANCE
SN 0007-9960
J9 CAH NUTR DIET
JI Cah. Nutr. Diet.
PD DEC
PY 2023
VL 58
IS 6
BP 399
EP 409
DI 10.1016/j.cnd.2023.10.004
EA DEC 2023
PG 11
WC Nutrition & Dietetics
WE Emerging Sources Citation Index (ESCI)
SC Nutrition & Dietetics
GA DZ0K0
UT WOS:001135793500001
DA 2025-06-11
ER

PT J
AU Ward, LJ
   Hammar, M
   Lindh-Åstrand, L
   Berin, E
   Lindblom, H
   Rubér, M
   Holm, ACS
   Li, W
AF Ward, Liam J.
   Hammar, Mats
   Lindh-Astrand, Lotta
   Berin, Emilia
   Lindblom, Hanna
   Ruber, Marie
   Holm, Anna-Clara Spetz
   Li, Wei
TI Does resistance training have an effect on levels of ferritin and
   atherogenic lipids in postmenopausal women? - A pilot trial
SO SCIENTIFIC REPORTS
LA English
DT Article
ID OXIDATIVE STRESS MARKERS; PHYSICAL-ACTIVITY; SERUM FERRITIN; METABOLIC
   SYNDROME; HOT FLUSHES; EXERCISE; ATHEROSCLEROSIS; RISK; RESPONSES;
   STROKE
AB The objective of this study was to determine if 15 weeks of resistance training (RT) can alter the levels of blood lipids, body iron status, and oxidative stress in postmenopausal women with vasomotor symptoms. Postmenopausal women enrolled in a randomised controlled trial were allocated to either a sedentary control group (n=29) or a RT group (n=26). Blood samples were taken at week-0 and week-15 for all participants. Blood lipids and iron status were measured via routine clinical analyses. Immunoassays were used to measure oxidative stress markers. The RT group, with good compliance, was associated with significant reductions in ferritin, total cholesterol, low-density lipoprotein, and non-high-density lipoprotein cholesterol. Moreover, ferritin was positively correlated with atherogenic lipids while negatively correlated with high-density lipoprotein in RT women. This occurred without alterations in serum iron, transferrin, transferrin-saturation, C-reactive protein and oxidative stress markers. No differences were found in control women. This study suggests that RT in postmenopausal women both reduces levels of ferritin and counteracts atherogenic lipid profiles independent of an apparent oxidative mechanism. RT may be a beneficial intervention in postmenopausal women via an interaction between ferritin and lipids; however, further investigation in a larger cohort is essential.
C1 [Ward, Liam J.; Hammar, Mats; Lindh-Astrand, Lotta; Berin, Emilia; Ruber, Marie; Holm, Anna-Clara Spetz; Li, Wei] Linkoping Univ, Dept Obstet & Gynaecol Linkoping, Linkoping, Sweden.
   [Ward, Liam J.; Hammar, Mats; Lindh-Astrand, Lotta; Berin, Emilia; Ruber, Marie; Holm, Anna-Clara Spetz; Li, Wei] Linkoping Univ, Dept Biomed & Clin Sci, Linkoping, Sweden.
   [Ward, Liam J.] Linkoping Univ, Occupat & Environm Med Ctr Linkoping, Linkoping, Sweden.
   [Ward, Liam J.] Linkoping Univ, Dept Hlth Med & Caring Sci, Linkoping, Sweden.
   [Lindblom, Hanna] Linkoping Univ, Dept Hlth Med & Caring Sci, Unit Physiotherapy, Linkoping, Sweden.
C3 Linkoping University; Linkoping University; Linkoping University;
   Linkoping University; Linkoping University
RP Ward, LJ; Li, W (corresponding author), Linkoping Univ, Dept Obstet & Gynaecol Linkoping, Linkoping, Sweden.; Ward, LJ; Li, W (corresponding author), Linkoping Univ, Dept Biomed & Clin Sci, Linkoping, Sweden.; Ward, LJ (corresponding author), Linkoping Univ, Occupat & Environm Med Ctr Linkoping, Linkoping, Sweden.; Ward, LJ (corresponding author), Linkoping Univ, Dept Hlth Med & Caring Sci, Linkoping, Sweden.
EM liam.ward@liu.se; wei.li@liu.se
RI Ward, Liam/GQA-7812-2022
OI Berin, Emilia/0000-0002-3805-8705; Ward, Liam J./0000-0002-3320-1461
FU Swedish Research Council (VR); Olle Engkvist Foundation; Swedish Gamla
   Tjanarinnor Foundation; Linkoping University Hospital Research Fund;
   Linkoping University
FX The work was supported by grants from the Swedish Research Council (VR),
   Olle Engkvist Foundation, Swedish Gamla Tjanarinnor Foundation, and
   Linkoping University Hospital Research Fund. The authors would like to
   thank research nurses Asa Rydmark Kersley and Linda Shosholli for their
   support with blood sampling and meta-data. The authors would also like
   to thank Associate Professor Xi-Ming Yuan for his feedback and input in
   critiquing the manuscript. Open access funding provided by Linkoping
   University.
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NR 33
TC 8
Z9 9
U1 0
U2 2
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD MAR 2
PY 2020
VL 10
IS 1
AR 3838
DI 10.1038/s41598-020-60759-z
PG 8
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA NB8ZY
UT WOS:000560805700001
PM 32123242
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Qi, GY
   Mi, YS
   Fan, R
   Zhao, BT
   Ren, B
   Liu, XB
AF Qi, Guoyuan
   Mi, Yashi
   Fan, Rong
   Zhao, Beita
   Ren, Bo
   Liu, Xuebo
TI Tea polyphenols ameliorates neural redox imbalance and mitochondrial
   dysfunction via mechanisms linking the key circadian regular Bmal1
SO FOOD AND CHEMICAL TOXICOLOGY
LA English
DT Article
DE Tea polyphenols; Oxidative stress; Circadian clock; Bmal1; Mitochondrial
   function
ID OXIDATIVE STRESS; METABOLIC SYNDROME; CLOCK; EXPRESSION; APOPTOSIS;
   DYNAMICS; PATHWAY; MEMORY; BDNF; DIET
AB Circadian rhythms are autonomous anticipatory oscillators that control a large array of physiological and metabolic processes. Compelling evidence points toward an interplay between circadian rhythms and cellular redox metabolism. Dysregulation of circadian rhythms is associated with neurodegenerative diseases and accelerated aging. Tea polyphenols (TP) is one of the most used antioxidants and exerts beneficial effect on neurodegenerative diseases. The aim of this study is to investigate whether circadian clock mechanisms are involved in the protection effect of TP against neural redox imbalance and mitochondrial dysfunction in SH-SY5Y cells. In the current study, our results revealed that TP, as a Bmal1-enhancing natural compound, can reverse the relatively shallow daily oscillations of circadian clock genes transcription and protein expression in SH-SY5Y neuronal cells under oxidative stress conditions. Furthermore, TP pretreatment significantly ameliorated H2O2-elicited mitochondria impairment via manipulating mitochondrial dynamics and mitochondrial membrane potential, which is consistent with the recovery in expression of mitochondrial respiration complex I-IV in Bmal1-dependent efficiency. Furthermore, Bmal1 is involved in TP-stimulated Nrf2/ARE/HO-1 and AKT/CREB/BDNF signaling pathway. Hence, TP may serve as a nutritional preventive strategy in the recovery of oxidative stress related neurodegenerative disease via modulating circadian clock.
C1 [Qi, Guoyuan; Mi, Yashi; Fan, Rong; Zhao, Beita; Ren, Bo; Liu, Xuebo] Northwest A&F Univ, Coll Food Sci & Engn, Lab Funct Chem & Nutr Food, Yangling 712100, Shaanxi, Peoples R China.
C3 Northwest A&F University - China
RP Liu, XB (corresponding author), Northwest A&F Univ, Coll Food Sci & Engn, 28 Xi Nong Rd, Yangling 712100, Shaanxi, Peoples R China.
EM xueboliu@aliyun.com
RI Zhao, Beita/AAF-7526-2021; ren, bo/IST-0814-2023; /AAZ-9695-2020
FU National Key Research and Development Program of China [2016YFD0400601];
   National Natural Science Foundation of China [31571842]
FX This work was financially supported by the National Key Research and
   Development Program of China (No. 2016YFD0400601) and the National
   Natural Science Foundation of China (No.31571842).
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NR 65
TC 43
Z9 43
U1 1
U2 54
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0278-6915
EI 1873-6351
J9 FOOD CHEM TOXICOL
JI Food Chem. Toxicol.
PD DEC
PY 2017
VL 110
BP 189
EP 199
DI 10.1016/j.fct.2017.10.031
PG 11
WC Food Science & Technology; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Toxicology
GA FQ2TU
UT WOS:000418211700018
PM 29061316
DA 2025-06-11
ER

PT J
AU Thayer, Z
   Barbosa-Leiker, C
   McDonell, M
   Nelson, L
   Buchwald, D
   Manson, S
AF Thayer, Zaneta
   Barbosa-Leiker, Celestina
   McDonell, Michael
   Nelson, Lonnie
   Buchwald, Dedra
   Manson, Spero
TI Early life trauma, post-traumatic stress disorder, and allostatic load
   in a sample of American Indian adults
SO AMERICAN JOURNAL OF HUMAN BIOLOGY
LA English
DT Article
ID HEALTH DISPARITIES; METABOLIC SYNDROME; MENTAL-DISORDERS; NORTHERN
   PLAINS; CHILDHOOD ABUSE; SEXUAL-ABUSE; PREVALENCE; RISK; POPULATIONS;
   WOMEN
AB ObjectivesAmong American Indians, prior research has found associations between early life trauma and the development of post-traumatic stress disorder (PTSD) in adulthood. Given the physiological changes associated with PTSD, early life trauma could indirectly contribute to chronic disease risk. However, the impact of early life trauma on adult physical health in this population has not been previously investigated.
   MethodsWe evaluated associations among early life trauma, PTSD, and 13 physiological biomarkers that index cardiovascular, metabolic, neuroendocrine, anthropometric, and immune function in adulthood by conducting correlation and structural equation modeling path analyses (N=197). Physiological systems were analyzed individually as well as in a composite measure of allostatic load.
   ResultsWe found early life trauma was related to PTSD, which in turn was related to elevated allostatic load in adulthood. Among the various components of allostatic load, the neuroendocrine system was the only one significantly related to early life stress and subsequent PTSD development.
   ConclusionsChanges in allostatic load might reflect adaptive adjustments that maximize short-term survival by enhancing stress reactivity, but at a cost to later health. Interventions should focus on improving access to resources for children who experience early life trauma in order to avoid PTSD and other harmful sequelae.
C1 [Thayer, Zaneta] Da1rtmouth Coll, Dept Anthropol, Hanover, NH 03755 USA.
   [Barbosa-Leiker, Celestina; Nelson, Lonnie] Washington State Univ, Coll Nursing, Spokane, WA USA.
   [McDonell, Michael; Buchwald, Dedra] Washington State Univ, Elson S Floyd Coll Med, Spokane, WA USA.
   [Manson, Spero] Univ Colorado Anschutz, Community & Behav Hlth, Colorado Sch Publ Hlth, Denver, CO USA.
C3 Washington State University; Washington State University; Colorado
   School of Public Health
RP Thayer, Z (corresponding author), Dartmouth Coll, Dept Anthropol, Hinman Box 6047, Hanover, NH 03755 USA.
EM Zaneta.Thayer@Dartmouth.edu
RI Nelson, Lonnie/HPF-2690-2023; Thayer, Zaneta/AAU-3274-2020
OI Thayer, Zaneta/0000-0001-8028-942X
FU NHLI [R01 HL073824]; GCRC NIH grant M01 [RR00051];  [P20 MD006871]
FX This project was funded by NHLI R01 HL073824 and GCRC NIH grant M01
   #RR00051. Thayer was supported by P20 MD006871 while working on this
   study.
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NR 52
TC 44
Z9 56
U1 0
U2 32
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1042-0533
EI 1520-6300
J9 AM J HUM BIOL
JI Am. J. Hum. Biol.
PD MAY-JUN
PY 2017
VL 29
IS 3
AR e22943
DI 10.1002/ajhb.22943
PG 10
WC Anthropology; Biology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Anthropology; Life Sciences & Biomedicine - Other Topics
GA EU9MN
UT WOS:000401364000009
PM 27901290
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Fukuta, K
   Shirakami, Y
   Maruta, A
   Obara, K
   Iritani, S
   Nakamura, N
   Kochi, T
   Kubota, M
   Sakai, H
   Tanaka, T
   Shimizu, M
AF Fukuta, Kazufumi
   Shirakami, Yohei
   Maruta, Akinori
   Obara, Koki
   Iritani, Soichi
   Nakamura, Nobuhiko
   Kochi, Takahiro
   Kubota, Masaya
   Sakai, Hiroyasu
   Tanaka, Takuji
   Shimizu, Masahito
TI Preventive Effects of Pentoxifylline on the Development of Colonic
   Premalignant Lesions in Obese and Diabetic Mice
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE colorectal cancer; pentoxifylline; chemoprevention; obesity; oxidative
   stress; inflammation
ID PRENEOPLASTIC LESIONS; NONALCOHOLIC STEATOHEPATITIS; COLORECTAL-CANCER;
   MOLECULAR-MECHANISMS; METABOLIC SYNDROME; LIVER; INFLAMMATION; RISK;
   CARCINOGENESIS; CYTOKINE
AB Obesity and its related metabolic abnormalities, including enhanced oxidative stress and chronic inflammation, are closely related to colorectal tumorigenesis. Pentoxifylline (PTX), a methylxanthine derivative, has been reported to suppress the production of tumor necrosis factor (TNF)- and possess anti-inflammatory properties. The present study investigated the effects of PTX on the development of carcinogen-induced colorectal premalignant lesions in obese and diabetic mice. Male C57BL/KsJ-db/db mice, which are severely obese and diabetic, were administered weekly subcutaneous injections of the colonic carcinogen azoxymethane (15 mg/kg body weight) for four weeks and then received drinking water containing 125 or 500 ppm PTX for eight weeks. At the time of sacrifice, PTX administration markedly suppressed the development of premalignant lesions in the colorectum. The levels of oxidative stress markers were significantly decreased in the PTX-treated group compared with those in the untreated control group. In PTX-administered mice, the mRNA expression levels of cyclooxygenase (COX)-2, interleukin (IL)-6, and TNF-, and the number of proliferating cell nuclear antigen (PCNA)-positive cells in the colonic mucosa, were significantly reduced. These observations suggest that PTX attenuated chronic inflammation and oxidative stress, and prevented the development of colonic tumorigenesis in an obesity-related colon cancer model.
C1 [Fukuta, Kazufumi; Shirakami, Yohei; Maruta, Akinori; Obara, Koki; Iritani, Soichi; Nakamura, Nobuhiko; Kochi, Takahiro; Kubota, Masaya; Sakai, Hiroyasu; Shimizu, Masahito] Gifu Univ, Dept Gastroenterol, Grad Sch Med, Gifu 5011194, Japan.
   [Shirakami, Yohei] Gifu Univ, Dept Informat Clin Med, Grad Sch Med, Gifu 5011194, Japan.
   [Tanaka, Takuji] Gifu Municipal Hosp, Dept Pathol Diag, Gifu 5008513, Japan.
C3 Gifu University; Gifu University; Gifu Municipal Hospital
RP Shirakami, Y (corresponding author), Gifu Univ, Dept Gastroenterol, Grad Sch Med, Gifu 5011194, Japan.
EM kazufumi19780802@yahoo.co.jp; ys2443@gifu-u.ac.jp; mrak5844@yahoo.co.jp;
   silent_jealousy0308@yahoo.co.jp; is590124@yahoo.co.jp;
   xenon2112@gmail.com; kottii924@yahoo.co.jp; kubota-gif@umin.ac.jp;
   sakaih03@gifu-u.ac.jp; tmntt08@gmail.com; shimim-gif@umin.ac.jp
FU Ministry of Education, Science, Sports, and Culture of Japan [22790638,
   25460988, 26860498]; Grants-in-Aid for Scientific Research [15K19320,
   26860498] Funding Source: KAKEN
FX This work was supported in part by Grants-in-Aid from the Ministry of
   Education, Science, Sports, and Culture of Japan (No. 22790638,
   25460988, and 26860498).
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NR 45
TC 10
Z9 10
U1 0
U2 4
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD FEB
PY 2017
VL 18
IS 2
AR 413
DI 10.3390/ijms18020413
PG 11
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA EM6YD
UT WOS:000395457700181
PM 28212276
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Zhang, YQ
   Fischer, KE
   Soto, V
   Liu, YH
   Sosnowska, D
   Richardson, A
   Salmon, AB
AF Zhang, Yiqiang
   Fischer, Kathleen E.
   Soto, Vanessa
   Liu, Yuhong
   Sosnowska, Danuta
   Richardson, Arlan
   Salmon, Adam B.
TI Obesity-induced oxidative stress, accelerated functional decline with
   age and increased mortality in mice
SO ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
LA English
DT Article
DE Obesity; Rotarod; Longevity; Oxidation; Grip strength; Respirometry;
   Gait
ID INSULIN-RESISTANCE; LIFE-SPAN; ADIPOSE-TISSUE; HEALTH; OVEREXPRESSION;
   RESTRICTION; PREVALENCE; OVERWEIGHT; IMPACT; ADULTS
AB Obesity is a serious chronic disease that increases the risk of numerous co-morbidities including metabolic syndrome, cardiovascular disease and cancer as well as increases risk of mortality, leading some to suggest this condition represents accelerated aging. Obesity is associated with significant increases in oxidative stress in vivo and, despite the well-explored relationship between oxidative stress and aging, the role this plays in the increased mortality of obese subjects remains an unanswered question. Here, we addressed this by undertaking a comprehensive, longitudinal study of a group of high fat-fed obese mice and assessed both their changes in oxidative stress and in their performance in physiological assays known to decline with aging. In female C57BL/6J mice fed a high-fat diet starting in adulthood, mortality was significantly increased as was oxidative damage in vivo. High fat-feeding significantly accelerated the decline in performance in several assays, including activity, gait, and rotarod. However, we also found that obesity had little effect on other markers of function and actually improved performance in grip strength, a marker of muscular function. Together, this first comprehensive assessment of longitudinal, functional changes in high fat-fed mice suggests that obesity may induce segmental acceleration of some of the aging process. Published by Elsevier Inc.
C1 [Zhang, Yiqiang; Soto, Vanessa; Liu, Yuhong; Salmon, Adam B.] Univ Texas Hlth Sci Ctr San Antonio, Sam & Ann Barshop Inst Longev & Aging Studies, San Antonio, TX 78229 USA.
   [Zhang, Yiqiang] Univ Texas Hlth Sci Ctr San Antonio, Dept Physiol, San Antonio, TX 78229 USA.
   [Salmon, Adam B.] Univ Texas Hlth Sci Ctr San Antonio, Dept Mol Med, San Antonio, TX 78229 USA.
   [Salmon, Adam B.] South Texas Vet Hlth Care Syst, Ctr Geriatr Res Educ & Clin, San Antonio, TX USA.
   [Fischer, Kathleen E.] Univ Alabama Birmingham, Dept Biol, Birmingham, AL 35294 USA.
   [Sosnowska, Danuta; Richardson, Arlan] Univ Oklahoma, Hlth Sci Ctr, Reynolds Oklahoma Ctr Aging, Oklahoma City, OK USA.
   [Sosnowska, Danuta; Richardson, Arlan] Oklahoma City VA Med Ctr, Oklahoma City, OK USA.
C3 University of Texas System; University of Texas Health Science Center at
   San Antonio; University of Texas System; University of Texas Health
   Science Center at San Antonio; University of Texas System; University of
   Texas Health Science Center at San Antonio; US Department of Veterans
   Affairs; Veterans Health Administration (VHA); Audie L. Murphy Memorial
   Veterans Hospital; Geriatric Research Education & Clinical Center;
   University of Alabama System; University of Alabama Birmingham;
   University of Oklahoma System; University of Oklahoma Health Sciences
   Center; University of Oklahoma System; University of Oklahoma Health
   Sciences Center
RP Salmon, AB (corresponding author), 15355 Lambda Dr, San Antonio, TX 78245 USA.
EM salmona@uthscsa.edu
RI Zhang, Yiqiang/AAA-3143-2019; Sosnowska, Danuta/KHD-9993-2024
OI Sosnowska, Danuta/0000-0002-2291-5987
FU American Federation for Aging Research; Biomedical Laboratory Research &
   Development Service of the Veteran's Affairs Office of Research and
   Development [1I01BX000547]; Geriatric Research Education and Clinical
   Center of the South Texas Veterans Healthcare System
FX Animal studies were performed in the Healthspan and Functional
   Assessment Core of the San Antonio Nathan Shock Center of Excellence in
   the Basic Biology of Aging. This research was supported in part by
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   A.B.S.), the Biomedical Laboratory Research & Development Service of the
   Veteran's Affairs Office of Research and Development (1I01BX000547 to
   A.R.) and Geriatric Research Education and Clinical Center of the South
   Texas Veterans Healthcare System (A.B.S.).
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NR 45
TC 50
Z9 54
U1 1
U2 15
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0003-9861
EI 1096-0384
J9 ARCH BIOCHEM BIOPHYS
JI Arch. Biochem. Biophys.
PD JUN 15
PY 2015
VL 576
BP 39
EP 48
DI 10.1016/j.abb.2014.12.018
PG 10
WC Biochemistry & Molecular Biology; Biophysics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics
GA CK3LQ
UT WOS:000356118000006
PM 25558793
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Miao, LH
   Xie, J
   Ge, XP
   Wang, KB
   Zhu, J
   Liu, B
   Ren, MC
   Zhou, QL
   Pan, LK
AF Miao, Ling-Hong
   Xie, Jun
   Ge, Xian-Ping
   Wang, Ke-Bao
   Zhu, Jian
   Liu, Bo
   Ren, Ming-Chun
   Zhou, Qun-Lan
   Pan, Liang-Kun
TI Chronic stress effects of high doses of vitamin D3 on
   Megalobrama amblycephala
SO FISH & SHELLFISH IMMUNOLOGY
LA English
DT Article
DE Megalobrama amblycephala; Vitamin D-3; Chronic stress; Immunity; Tissue
   structure
ID METABOLIC SYNDROME; BREAM; REQUIREMENT; CALCIUM; PREVALENCE; DEFICIENCY;
   EXPRESSION; PARAMETERS; GROWTH; SALT
AB Dietary vitamin D-3 plays an important role in the growth of aquatic animals, but long-term excessive feeding has potential hazards. In this study, Megalobrama amblycephala specimens were fed different experimental diets with 2000 IU/kg or 200,000 IU/kg of vitamin D-3 for 90 days, in order to evaluate chronic stress effects of high doses of vitamin D-3 on growth, immunity, and structural damage to enterohepatic tissues. The results showed that high doses of vitamin D-3 did not have a significant influence on the growth performance of M. amblycephala (P > 0.05), but it significantly reduced the survival rate after infection by Aeromonas hydrophila (P < 0.05). Serum albumin, alkaline phosphatase, and insulin levels, as well as hepatic total antioxidant capacity, were also significantly reduced (P < 0.05). Serum cortisol levels and hepatic heat stress protein 70 expression in M. amblycephala showed that high doses of vitamin D-3 significantly inhibit the anti-stress ability of M. amblycephala (P < 0.05). Paraffin tissue sections and electron microscopy showed that high doses of vitamin D-3 could cause different degrees of structural damage to enterohepatic tissues of M. amblycephala. Our results indicate that, although M. amblycephala can tolerate high doses of dietary vitamin D-3 over a long period, its glycolipid metabolism, immune function, anti-stress function, and resistance to pathogenic infections are adversely affected. (C) 2015 Elsevier Ltd. All rights reserved.
C1 [Miao, Ling-Hong; Xie, Jun; Ge, Xian-Ping; Wang, Ke-Bao; Zhu, Jian; Liu, Bo; Zhou, Qun-Lan] Nanjing Agr Univ, Fishery Coll, Wuxi 214081, Peoples R China.
   [Miao, Ling-Hong; Xie, Jun; Ge, Xian-Ping; Zhu, Jian; Liu, Bo; Ren, Ming-Chun; Zhou, Qun-Lan; Pan, Liang-Kun] Chinese Acad Fishery Sci, Freshwater Fisheries Res Ctr, Minist Agr, Key Lab Genet Breeding & Aquaculture Biol Freshwa, Wuxi 214081, Jiangsu, Peoples R China.
C3 Nanjing Agricultural University; Ministry of Agriculture & Rural
   Affairs; Chinese Academy of Fishery Sciences; Freshwater Fisheries
   Research Center, CAFS
RP Ge, XP (corresponding author), Chinese Acad Fishery Sci, Freshwater Fisheries Res Ctr, 9 East Shanshui Rd, Wuxi 214081, Jiangsu, Peoples R China.
EM gexp@ffrc.cn; liub@ffrc.cn
RI Miao, Linghong/HLV-7382-2023; Liu, Bo/JBJ-7722-2023
FU China Agriculture Research System special project of National
   Conventional Freshwater Fishery Industry [CARS-46]; Special Fund for
   Agro-scientific Research in the Public Interest [201003020]
FX We are grateful to the graduate students and those from the Fish Disease
   and Nutrition Department, Freshwater Fisheries Research Center (FFRC),
   Chinese Academy of Fishery Sciences (CAFS). This work was funded by the
   China Agriculture Research System special project of National
   Conventional Freshwater Fishery Industry (CARS-46), and the Special Fund
   for Agro-scientific Research in the Public Interest (201003020).
CR [Anonymous], FISHERIES RES B
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NR 46
TC 9
Z9 11
U1 0
U2 34
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 1050-4648
EI 1095-9947
J9 FISH SHELLFISH IMMUN
JI Fish Shellfish Immunol.
PD NOV
PY 2015
VL 47
IS 1
BP 205
EP 213
DI 10.1016/j.fsi.2015.09.012
PG 9
WC Fisheries; Immunology; Marine & Freshwater Biology; Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Fisheries; Immunology; Marine & Freshwater Biology; Veterinary Sciences
GA CW5RC
UT WOS:000365053300024
PM 26362210
DA 2025-06-11
ER

PT J
AU Cienfuegos, S
   Gabel, K
   Kalam, F
   Ezpeleta, M
   Wiseman, E
   Pavlou, V
   Lin, SH
   Oliveira, ML
   Varady, KA
AF Cienfuegos, Sofia
   Gabel, Kelsey
   Kalam, Faiza
   Ezpeleta, Mark
   Wiseman, Eric
   Pavlou, Vasiliki
   Lin, Shuhao
   Oliveira, Manoela Lima
   Varady, Krista A.
TI Effects of 4-and 6-h Time-Restricted Feeding on Weight and
   Cardiometabolic Health: A Randomized Controlled Trial in Adults with
   Obesity
SO CELL METABOLISM
LA English
DT Article
ID CONTINUOUS ENERGY RESTRICTION; REDUCED MEAL FREQUENCY; CALORIC
   RESTRICTION; DISEASE RISK; BODY-WEIGHT; INTERMITTENT; OVERWEIGHT;
   METABOLISM; BREAKFAST; GLUCOSE
AB Time-restricted feeding (TRF) regimens have grown in popularity; however, very few studies have examined their weight-loss efficacy. We conducted the first human trial (Clinicaltrials.gov NCT03867773) to compare the effects of two popular forms of TRF (4 and 6 h) on body weight and cardiometabolic risk factors. Adults with obesity were randomized to 4-h TRF (eating only between 3 and 7 p.m.), 6-h TRF (eating only between 1 and 7 p.m.), or a control group (no meal timing restrictions). After 8 weeks, 4- and 6-h TRF produced comparable reductions in body weight (similar to 3%), insulin resistance, and oxidative stress, versus controls. Energy intake was reduced by similar to 550 kcal/day in both TRF groups, without calorie counting. These findings suggest that 4- and 6-h TRF induce mild reductions in body weight over 8 weeks and show promise as interventions for weight loss. These diets may also improve some aspects of cardiometabolic health.
C1 [Cienfuegos, Sofia; Gabel, Kelsey; Kalam, Faiza; Ezpeleta, Mark; Wiseman, Eric; Pavlou, Vasiliki; Lin, Shuhao; Oliveira, Manoela Lima; Varady, Krista A.] Univ Illinois, Dept Kinesiol & Nutr, Chicago, IL 60607 USA.
C3 University of Illinois System; University of Illinois Chicago;
   University of Illinois Chicago Hospital
RP Varady, KA (corresponding author), Univ Illinois, Dept Kinesiol & Nutr, Chicago, IL 60607 USA.
EM varady@uic.edu
RI Kalam, Faiza/AAD-6807-2021; Lin, Shuhao/KRP-5717-2024; Wiseman,
   Eric/E-2336-2017
OI Kalam, Faiza/0000-0003-4326-4009; Pavlou, Vasiliki/0000-0001-9486-9310;
   Lima Oliveira, Manoela/0000-0002-6751-0684
FU National Institutes of Health [R01DK119783]
FX The authors would like to thank the study participants for their time
   and effort in participating in the trial. We would also like to thank
   Nicolas Cote for his assistance in preparing the graphical abstract.
   This study was supported by R01DK119783 from the National Institutes of
   Health. The content is solely the responsibility of the authors and does
   not necessarily represent the official views of the National Institutes
   of Health.
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NR 58
TC 358
Z9 385
U1 11
U2 109
PU CELL PRESS
PI CAMBRIDGE
PA 50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA
SN 1550-4131
EI 1932-7420
J9 CELL METAB
JI Cell Metab.
PD SEP 1
PY 2020
VL 32
IS 3
BP 366
EP +
DI 10.1016/j.cmet.2020.06.018
PG 16
WC Cell Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Endocrinology & Metabolism
GA NN5QZ
UT WOS:000568844300009
PM 32673591
OA Green Accepted, Bronze
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Marinho, PC
   Vieira, AB
   Pereira, PG
   Rabelo, K
   Ciambarella, BT
   Nascimento, ALR
   Cortez, E
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   Guimaraes, FV
   Martins, MA
   Barquero, G
   Ferreira, RN
   de Carvalho, JJ
AF Marinho, Polyana C.
   Vieira, Aline B.
   Pereira, Priscila G.
   Rabelo, Kissila
   Ciambarella, Bianca T.
   Nascimento, Ana L. R.
   Cortez, Erika
   Moura, Anibal S.
   Guimaraes, Fernanda V.
   Martins, Marco A.
   Barquero, Gonzalo
   Ferreira, Rodrigo N.
   de Carvalho, Jorge J.
TI Capybara Oil Improves Hepatic Mitochondrial Dysfunction, Steatosis, and
   Inflammation in a Murine Model of Nonalcoholic Fatty Liver Disease
SO EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Article
ID METABOLIC SYNDROME; ALANINE AMINOTRANSFERASE; INSULIN-RESISTANCE;
   OXIDATIVE STRESS; MICE; STEATOHEPATITIS; PREVALENCE; FIBROSIS; OBESITY;
   NASH
AB Nonalcoholic fatty liver disease (NAFLD) is recognized as the most common cause of liver dysfunction worldwide and is commonly associated with obesity. Evidences suggest that NAFLD might be a mitochondrial disease, which contributes to the hepatic steatosis, oxidative stress, cytokine release, and cell death. Capybara oil (CO) is a rich source of polyunsaturated fatty acids (PUPA), which is known to improve inflammation and oxidative stress. In order to determine the effects of CO on NAFLD, C57Bl/6 mice were divided into 3 groups and fed a high-fat diet (HFD) (NAFLD group and NAFLD + CO group) or a control diet (CG group) during 16 weeks. The CO (1.5 g/kg/daily) was administered by gavage during the last 4 weeks of the diet protocol. We evaluated plasma liver enzymes, hepatic steatosis, and cytokine expression in liver as well as hepatocyte ultrastructural morphology and mitochondrial function. CO treatment suppressed hepatic steatosis, attenuated inflammatory response, and decreased plasma alanine aminotransferase (ALT) in mice with NAFLD. CO was also capable of restoring mitochondrial ultrastructure and function as well as balance superoxide dismutase and catalase levels. Our findings indicate that CO treatment has positive effects on NAFLD improving mitochondrial dysfunction, steatosis, acute inflammation, and oxidative stress.
C1 [Marinho, Polyana C.; Pereira, Priscila G.; Rabelo, Kissila; Ciambarella, Bianca T.; Nascimento, Ana L. R.; de Carvalho, Jorge J.] Univ Estado Rio De Janeiro, Inst Biol, Lab Ultrastruct & Tissue Biol, Rio De Janeiro, RJ, Brazil.
   [Vieira, Aline B.] Ross Univ Sch Vet Med, Biomed Sci Dept, Basseterre, St Kitts & Nevi.
   [Cortez, Erika] Univ Estado Rio De Janeiro, Inst Biol, Lab Stem Cells Res, Rio De Janeiro, RJ, Brazil.
   [Moura, Anibal S.] Univ Estado Rio De Janeiro, Inst Biol, Lab Nutr & Dev Physiol, Rio De Janeiro, RJ, Brazil.
   [Guimaraes, Fernanda V.; Martins, Marco A.] Fiocruz MS, Oswaldo Cruz Inst, Lab Inflammat, Rio De Janeiro, RJ, Brazil.
   [Barquero, Gonzalo] Trop Sustainabil Inst, Sao Paulo, SP, Brazil.
   [Ferreira, Rodrigo N.] Dom Andre Arcoverde Educ Fdn, Coll Valenca, Valenca, RJ, Brazil.
C3 Universidade do Estado do Rio de Janeiro; Universidade do Estado do Rio
   de Janeiro; Universidade do Estado do Rio de Janeiro; Fundacao Oswaldo
   Cruz
RP Vieira, AB (corresponding author), Ross Univ Sch Vet Med, Biomed Sci Dept, Basseterre, St Kitts & Nevi.
EM avieira@rossvet.edu.kn
RI Cortez, Erika/G-5067-2019; Rabelo, Kíssila/AAP-3595-2021; MARTINS,
   MARCO/HJH-3671-2023; Barquero, Gonzalo/AAE-9261-2019
OI Marinho, Polyana/0000-0002-9896-9850; Vieira, Aline/0000-0002-2479-6774;
   Afonso Costa Cortez Marques, Erika/0000-0003-0262-061X; Rabelo,
   Kissila/0000-0001-7579-7788; Pereira, Priscila/0000-0002-0480-2604;
   Carvalho, Jorge/0000-0002-9426-6381; Martins, Marco
   Aurelio/0000-0002-4708-5705
FU Fundacao Carlos Chagas Filho de Amparo a Pesquisa do Estado do Rio de
   Janeiro (FAPERJ); Conselho Nacional de Desenvolvimento Cientifico e
   Tecnologico (CNPq); Coordenacao de Aperfeicoamento de Pessoal de nivel
   Superior (Capes); Universidade do Estado do Rio de Janeiro (UERJ); Ross
   University School of Veterinary Medicine
FX This work was supported by the Fundacao Carlos Chagas Filho de Amparo a
   Pesquisa do Estado do Rio de Janeiro (FAPERJ), Conselho Nacional de
   Desenvolvimento Cientifico e Tecnologico (CNPq), Coordenacao de
   Aperfeicoamento de Pessoal de nivel Superior (Capes), Universidade do
   Estado do Rio de Janeiro (UERJ), and Ross University School of
   Veterinary Medicine.
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NR 65
TC 5
Z9 5
U1 0
U2 8
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1741-427X
EI 1741-4288
J9 EVID-BASED COMPL ALT
JI Evid.-based Complement Altern. Med.
PY 2018
VL 2018
AR 4956079
DI 10.1155/2018/4956079
PG 9
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA GF5JM
UT WOS:000432003000001
PM 29853957
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Stephens, JW
   Bain, SC
   Humphries, SE
AF Stephens, Jeffrey W.
   Bain, Stephen C.
   Humphries, Steve E.
TI Gene-environment interaction and oxidative stress in cardiovascular
   disease
SO ATHEROSCLEROSIS
LA English
DT Review
DE Gene variant; Oxidative stress; Smoking; UCP2; ApoE; Glutathione
   transferase
ID CORONARY-HEART-DISEASE; S-TRANSFERASE M1; APOLIPOPROTEIN-E POLYMORPHISM;
   UNCOUPLING PROTEIN-2; LIPID-PEROXIDATION; COMMON POLYMORPHISM; METABOLIC
   SYNDROME; DIABETES-MELLITUS; CIGARETTE-SMOKING; INCREASED PLASMA
AB Coronary heart disease (CHID) is a leading cause of death worldwide. CHD is complex and despite increased knowledge within vascular biology, traditional risk factors appear not to contribute to risk in a proportion of the population. Within this review, we look at the concept of gene-environment interaction in relation to plasma markers of oxidative stress and cardiovascular disease (CVD) risk. Growing evidence suggests that increased oxidative burden plays an important role in CVD. Genetic variation in antioxidant genes may determine the homeostatic response in an environment (e.g. smoking) of increased oxidative burden. To date, the influence of genetic variation on such plasma markers has been limited due to the lack of a robust measurement in a large number of samples often required in gene-association studies. This also explains the inability to look at gene-environment interaction within the limited number of published studies. We examine in detail the association between plasma markers of oxidative stress and LDL-oxidation with variants from three specific candidate genes: apolipoprotein E (a plasma lipoprotein), mitochondrial uncoupling protein 2 (a mitochondrial antioxidant) and glutathione-S-transferase (a cellular antioxidant protein). (C) 2008 Elsevier Ireland Ltd. All rights reserved.
C1 [Stephens, Jeffrey W.; Bain, Stephen C.] Swansea Univ, Diabet Res Grp, Inst Life Sci, Swansea SA2 8PP, W Glam, Wales.
   [Humphries, Steve E.] Royal Free & Univ Coll, Sch Med, Ctr Cardiovasc Genet, British Heart Fdn Labs, London WC1E 6JF, England.
C3 Swansea University; University of London; University College London; UCL
   Medical School
RP Stephens, JW (corresponding author), Swansea Univ, Diabet Res Grp, Inst Life Sci, Swansea SA2 8PP, W Glam, Wales.
EM J.W.Stephens@Swansea.ac.uk
RI Humphries, Stephen/C-5075-2008
OI Humphries, Stephen E/0000-0002-8221-6547
FU Diabetes UK; BUPA Foundation; Novo Nordisk; British Heart Foundation
   [RG2005/014]
FX JS current research is supported by grants from Diabetes UK, the BUPA
   Foundation and Novo Nordisk. SEH is supported by the British Heart
   Foundation (RG2005/014).
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NR 87
TC 45
Z9 49
U1 0
U2 11
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0021-9150
EI 1879-1484
J9 ATHEROSCLEROSIS
JI Atherosclerosis
PD OCT
PY 2008
VL 200
IS 2
BP 229
EP 238
DI 10.1016/j.atherosclerosis.2008.04.003
PG 10
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 368UJ
UT WOS:000260647700001
PM 18490019
DA 2025-06-11
ER

PT J
AU Takai, K
   Funaba, M
   Matsui, T
AF Takai, Katsuko
   Funaba, Masayuki
   Matsui, Tohru
TI Steatohepatitis is developed by a diet high in fat, sucrose, and
   cholesterol without increasing iron concentration in rat liver
SO BIOLOGICAL TRACE ELEMENT RESEARCH
LA English
DT Article
DE Western diet; Iron; Oxidative stress; Nonalcoholic steatohepatitis; Rat
ID NONALCOHOLIC STEATOHEPATITIS; HEPATIC IRON; METABOLIC SYNDROME;
   OXIDATIVE STRESS; FIBROSIS; DISEASE; MODEL; INFLAMMATION; DEFICIENCY;
   LEVEL
AB Iron overload to the liver is known to be a pathogenesis of nonalcoholic steatohepatitis through oxidative stress. High-fat diets have been reported to increase iron concentration in livers that developed steatohepatitis in experimental animals. However, the effect of high-fat diets on hepatic iron concentration is controversial. We hypothesized that a diet high in lard, cholesterol, and sucrose (Western diet) leads to the development of steatohepatitis without increasing hepatic iron concentration. Rats were given either a control or the Western diet for 12 weeks. The Western diet increased triacylglycerol concentration and oxidative stress markers such as the concentration of thiobarbituric acid reactive substances and messenger RNA (mRNA) expression of heme oxygenase-1 in the liver. The Western diet also increased the mRNA expression of macrophage-1 antigen, cluster of differentiation (CD) 45, and CD68 in the liver, and nuclear factor kappa B level in liver nuclear fraction, suggesting the development of hepatic inflammation. Histological observation also indicated fatty liver and hepatic inflammation in the rats given the Western diet. In contrast, the Western diet decreased iron concentration in the liver. These results clearly indicated that the diet high in lard, cholesterol, and sucrose induces steatohepatitis without increasing hepatic iron concentration.
C1 [Takai, Katsuko; Funaba, Masayuki; Matsui, Tohru] Kyoto Univ, Div Appl Biosci, Grad Sch Agr, Kitashirakawa Oiwake Cho, Kyoto 6068502, Japan.
C3 Kyoto University
RP Matsui, T (corresponding author), Kyoto Univ, Div Appl Biosci, Grad Sch Agr, Kitashirakawa Oiwake Cho, Kyoto 6068502, Japan.
EM matsui@kais.kyoto-u.ac.jp
RI Funaba, Masayuki/E-4676-2018
OI Funaba, Masayuki/0000-0002-4303-6682; Matsui, Tohru/0000-0002-6363-1788;
   Matsui, Tohru/0000-0003-1011-7053
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NR 46
TC 2
Z9 2
U1 0
U2 6
PU HUMANA PRESS INC
PI TOTOWA
PA 999 RIVERVIEW DRIVE SUITE 208, TOTOWA, NJ 07512 USA
SN 0163-4984
EI 1559-0720
J9 BIOL TRACE ELEM RES
JI Biol. Trace Elem. Res.
PD APR
PY 2016
VL 170
IS 2
BP 401
EP 409
DI 10.1007/s12011-015-0494-1
PG 9
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA DH0JT
UT WOS:000372471200019
PM 26340976
DA 2025-06-11
ER

PT J
AU Xu, XJ
   Pories, WJ
   Dohm, LG
   Ruderman, NB
AF Xu, X. Julia
   Pories, Walter J.
   Dohm, Lynis G.
   Ruderman, Neil B.
TI What distinguishes adipose tissue of severely obese humans who are
   insulin sensitive and resistant?
SO CURRENT OPINION IN LIPIDOLOGY
LA English
DT Review
DE AMP-activated protein kinase; inflammation; insulin resistance;
   oxidative stress; SIRT1
ID ACTIVATED PROTEIN-KINASE; NF-KAPPA-B; BODY-MASS INDEX; MITOCHONDRIAL
   BIOGENESIS; INDUCED INFLAMMATION; BARIATRIC SURGERY; OXIDATIVE STRESS;
   SIRT1; MORTALITY; MECHANISM
AB Purpose of review
   Despite a strong correlation between obesity and insulin resistance, 25% of severely obese (BMI > 40) individuals are insulin sensitive. In this review, we will examine the factors in adipose tissue that distinguish the two groups, as well as reasons for believing the insulin-sensitive group will be less disease prone.
   Recent findings
   Obesity has been linked to the metabolic syndrome with an increase in visceral (intra-abdominal) compared to subcutaneous fat. Recent studies in which adipose tissue of insulin-sensitive and insulin-resistant patients with severe obesity were compared indicate that the insulin-resistant group is also distinguished by increases in oxidative stress and decreases in AMP-activated protein kinase (AMPK) activity. In contrast, changes in the expression of genes for SIRT1, inflammatory cytokines, mitochondrial biogenesis and function, and the two alpha-isoforms of AMPK showed more depot variation. Studies of how these and other changes in adipose tissue respond to bariatric surgery are still in their infancy.
   Summary
   Available data suggest that increases in oxidative stress, decreases in AMPK activity and SIRT1 gene expression, depot-specific changes in inflammatory, mitochondrial and other genes distinguish adipose tissue of insulin resistant from insulin-sensitive individuals with severe obesity.
C1 [Xu, X. Julia; Ruderman, Neil B.] Boston Univ, Med Ctr, Dept Med, Diabet & Metab Unit,Sect Endocrinol, Boston, MA USA.
   [Pories, Walter J.; Dohm, Lynis G.] E Carolina Univ, Brody Sch Med, Dept Internal Med, Sect Endocrinol & Metab, Greenville, NC USA.
C3 Boston University; University of North Carolina; East Carolina
   University
RP Ruderman, NB (corresponding author), Room 820,650 Albany St, Boston, MA 02118 USA.
EM nrude@bu.edu
OI Ruderman, Neil/0000-0002-6589-6587; Xu, Julia/0000-0002-2564-8052
FU NIH [2R01DK019514-31, 1R24DK094749-01]
FX This work was supported by the NIH grants 2R01DK019514-31 and
   1R24DK094749-01. The authors thank Drs Caroline Apovian, Konstantin
   Kandror, Barbara Nikolajczyk, Vishwajeet Puri, and Orian Shirihai for
   their helpful comments and Ayesha Iyer, Christina Nielsen, and Nga Tong
   for assistance in preparing the manuscript. The authors have no conflict
   of interest to declare.
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NR 52
TC 21
Z9 28
U1 0
U2 19
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0957-9672
EI 1473-6535
J9 CURR OPIN LIPIDOL
JI Curr. Opin. Lipidology
PD FEB
PY 2013
VL 24
IS 1
BP 49
EP 56
DI 10.1097/MOL.0b013e32835b465b
PG 8
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism; Peripheral
   Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism;
   Cardiovascular System & Cardiology
GA 070YL
UT WOS:000313550500008
PM 23298959
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Lastra, G
   Manrique, C
AF Lastra, Guido
   Manrique, Camila
TI The expanding role of oxidative stress, renin angiotensin system, and
   β-cell dysfunction in the cardiometabolic syndrome and type 2 diabetes
   mellitus
SO ANTIOXIDANTS & REDOX SIGNALING
LA English
DT Review
ID ISLET AMYLOID POLYPEPTIDE; RAT PANCREATIC-ISLETS; ENDOPLASMIC-RETICULUM
   STRESS; METABOLIC SYNDROME; INSULIN-SECRETION; GENE-EXPRESSION;
   CHILDHOOD OBESITY; GLUCOSE TOXICITY; TRANSGENIC MICE; STELLATE CELLS
AB The incidence of obesity, cardiometabolic syndrome (CMS), and type 2 diabetes mellitus (DM2), as well as their devastating cardiovascular consequences, keep rising with increasing human and economical costs. For a long time, insulin resistance has been the main player in the pathogenesis and treatment of DM2, but every day more knowledge is gained about the central role of beta-cell failure, not only in the appearance of hyperglycemia but also in the failure of the pharmacological therapy. beta-Cell failure implies impairment of glucose-stimulated insulin secretion and loss of beta-cell mass. Hyperglycemia, elevated circulating fatty acids, inadequate local activation of renin angiotensin system, and chronic low grade inflammation are conditions that coexist in the CMS and DM2 that turn out to be deleterious for the beta-cell functioning and existance. Excessive oxidative stress secondary to increased production of reactive oxygen species and decreased availability of antioxidants is a possible common converging point of the multiple noxious stimuli. Activation of the NADPH oxidase complex secondary to angiotensin II stimulation is of interest, as its pharmacological blockade has beneficial effects. New knowledge about the intimate mechanisms of oxidative-stress induced beta-cell failure will provide new therapeutic targets against CMS and DM2.
C1 Univ Missouri, Dept Internal Med, Columbia, MO 65211 USA.
C3 University of Missouri System; University of Missouri Columbia
RP Lastra, G (corresponding author), Univ Missouri, Dept Internal Med, Columbia, MO 65211 USA.
EM lastrag@health.missouri.edu
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NR 114
TC 29
Z9 34
U1 0
U2 9
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1523-0864
EI 1557-7716
J9 ANTIOXID REDOX SIGN
JI Antioxid. Redox Signal.
PD JUL
PY 2007
VL 9
IS 7
BP 943
EP 954
DI 10.1089/ars.2007.1615
PG 12
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 170EW
UT WOS:000246646200013
PM 17508916
DA 2025-06-11
ER

PT J
AU Apaijit, K
   Pakdeechote, P
   Maneesai, P
   Meephat, S
   Prasatthong, P
   Bunbupha, S
AF Apaijit, Kwanjit
   Pakdeechote, Poungrat
   Maneesai, Putcharawipa
   Meephat, Sariya
   Prasatthong, Patoomporn
   Bunbupha, Sarawoot
TI Hesperidin alleviates vascular dysfunction and remodelling in
   high-fat/high-fructose diet-fed rats by modulating oxidative stress,
   inflammation, AdipoR1, and eNOS expression
SO TISSUE & CELL
LA English
DT Article
DE Hesperidin; High-fat/high-fructose diet; Oxidative stress; Inflammation;
   Adiponectin receptor 1; Endothelial nitric oxide synthase
ID NITRIC-OXIDE PRODUCTION; METABOLIC SYNDROME; HIGH-CARBOHYDRATE;
   MECHANISMS
AB Hesperidin, a flavanone glycoside, has shown antihypertensive, antioxidant, and anti-inflammatory effects. In the present study, the therapeutic effects of hesperidin on vascular function and remodelling, and possible underlying mechanisms involved in high-fat/high-fructose diet (HFFD)-fed rats were investigated. Male Sprague-Dawley rats were fed a high-fat diet plus 15% fructose in drinking water for 16 weeks. HFFD-fed rats were treated with hesperidin (30 mg/kg/day) or vehicle for the last 4 weeks. Treatment of HFFD-fed rats with hesperidin significantly attenuated metabolic alterations, vascular endothelial dysfunction and remodelling. Hesperidin markedly alleviated HFFD-induced oxidative stress and inflammation by decreasing plasma malondialdehyde level and aortic superoxide anion production, and by suppressing aortic tumor necrosis factor-alpha and interleukin-6 overexpression. Additionally, increased plasma levels of the adiponectin and nitric oxide metabolite, together with restoration of adiponectin receptor 1 (AdipoR1) and endothelial nitric oxide synthase (eNOS) protein expression, were also observed after treatment with hesperidin. These findings indicated that hesperidin alleviates HFFD-induced vascular dysfunction and remodelling in rats. The possible underlying mechanism may involve the reduction of oxidative stress and inflammation, and the restoration of AdipoR1and eNOS expression.
C1 [Apaijit, Kwanjit; Bunbupha, Sarawoot] Mahasarakham Univ, Fac Med, Maha Sarakham 44000, Thailand.
   [Pakdeechote, Poungrat; Maneesai, Putcharawipa; Meephat, Sariya] Khon Kaen Univ, Dept Physiol, Fac Med, Khon Kaen 40002, Thailand.
   [Prasatthong, Patoomporn] Nakhon Sawan Rajabhat Univ, Fac Sci & Technol, Dept Hlth Sci, Nakhon Sawan 60000, Thailand.
   [Pakdeechote, Poungrat] Khon Kaen Univ, Res Inst Human High Performance & Hlth Promot, Khon Kaen 40002, Thailand.
C3 Mahasarakham University; Khon Kaen University; Nakhon Sawan Rajabhat
   University; Khon Kaen University
RP Bunbupha, S (corresponding author), Mahasarakham Univ, Fac Med, Maha Sarakham 44000, Thailand.
EM sarawoot.b@msu.ac.th
RI Maneesai, Putcharawipa/AAK-4258-2021
OI Maneesai, Putcharawipa/0000-0003-0889-6211
FU Faculty of Medicine, Mahasarakham University, Thailand [Med.
   Msu.6501006]
FX This research project was financially supported by a grant from Faculty
   of Medicine, Mahasarakham University, Thailand (Med. Msu.6501006). The
   authors thank Dr. Adrian Roderick Plant for valuable suggestions and
   language editing of the manuscript.
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NR 31
TC 2
Z9 3
U1 2
U2 11
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0040-8166
J9 TISSUE CELL
JI Tissue Cell
PD OCT
PY 2022
VL 78
AR 101901
DI 10.1016/j.tice.2022.101901
PG 8
WC Anatomy & Morphology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Anatomy & Morphology; Cell Biology
GA DE1V8
UT WOS:001130271900006
PM 36007378
DA 2025-06-11
ER

PT J
AU Balan, AI
   Halatiu, VB
   Scridon, A
AF Balan, Alkora Ioana
   Halatiu, Vasile Bogdan
   Scridon, Alina
TI Oxidative Stress, Inflammation, and Mitochondrial Dysfunction: A Link
   between Obesity and Atrial Fibrillation
SO ANTIOXIDANTS
LA English
DT Review
DE atrial fibrillation; inflammation; mitochondrial dysfunction; obesity;
   oxidative stress
ID NECROSIS-FACTOR-ALPHA; ADIPOSE-TISSUE; INSULIN-RESISTANCE;
   HEART-FAILURE; ENDOTHELIAL DYSFUNCTION; CARDIAC-SURGERY; RISK-FACTOR;
   DECREASES; FIBROSIS; SUBSTRATE
AB The adipose tissue has long been thought to represent a passive source of triglycerides and fatty acids. However, extensive data have demonstrated that the adipose tissue is also a major endocrine organ that directly or indirectly affects the physiological functions of almost all cell types. Obesity is recognized as a risk factor for multiple systemic conditions, including metabolic syndrome, type 2 diabetes mellitus, sleep apnea, cardiovascular disorders, and many others. Obesity-related changes in the adipose tissue induce functional and structural changes in cardiac myocytes, promoting a wide range of cardiovascular disorders, including atrial fibrillation (AF). Due to the wealth of epidemiologic data linking AF to obesity, the mechanisms underlying AF occurrence in obese patients are an area of rich ongoing investigation. However, progress has been somewhat slowed by the complex phenotypes of both obesity and AF. The triad inflammation, oxidative stress, and mitochondrial dysfunction are critical for AF pathogenesis in the setting of obesity via multiple structural and functional proarrhythmic changes at the level of the atria. The aim of this paper is to provide a comprehensive view of the close relationship between obesity-induced oxidative stress, inflammation, and mitochondrial dysfunction and the pathogenesis of AF. The clinical implications of these mechanistic insights are also discussed.
C1 [Balan, Alkora Ioana; Scridon, Alina] Univ Med Pharm Sci & Technol George Emil Palade Ta, Ctr Adv Med & Pharmaceut Res, Targu Mures 540142, Romania.
   [Halatiu, Vasile Bogdan; Scridon, Alina] Univ Med Pharm Sci & Technol George Emil Palade Ta, Physiol Dept, Targu Mures 540142, Romania.
RP Scridon, A (corresponding author), Univ Med Pharm Sci & Technol George Emil Palade Ta, Ctr Adv Med & Pharmaceut Res, Targu Mures 540142, Romania.; Scridon, A (corresponding author), Univ Med Pharm Sci & Technol George Emil Palade Ta, Physiol Dept, Targu Mures 540142, Romania.
EM alkora-ioana.balan@umfst.ro; bogdan.halatiu@umfst.ro;
   alina.scridon@umfst.ro
RI Balan, Alkora/AID-8491-2022; Halatiu, Vasile/AAM-4641-2021
OI Halatiu, Vasile Bogdan/0000-0001-6793-9248
FU University of Medicine, Pharmacy, Science and Technology
FX No Statement Available
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NR 157
TC 23
Z9 24
U1 1
U2 16
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD JAN
PY 2024
VL 13
IS 1
AR 117
DI 10.3390/antiox13010117
PG 21
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA FW9X6
UT WOS:001149018800001
PM 38247541
OA Green Published, gold
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Andreazza, AC
   Barakauskas, VE
   Fazeli, S
   Feresten, A
   Shao, L
   Wei, V
   Wu, CH
   Barr, AM
   Beasley, CL
AF Andreazza, Ana C.
   Barakauskas, Vilte E.
   Fazeli, Salar
   Feresten, Abigail
   Shao, Li
   Wei, Vivien
   Wu, Che Hsuan
   Barr, Alasdair M.
   Beasley, Clare L.
TI Effects of haloperidol and clozapine administration on oxidative stress
   in rat brain, liver and serum
SO NEUROSCIENCE LETTERS
LA English
DT Article
DE Antioxidant; Antipsychotic agent; Lipid peroxidation; Peroxiredoxin;
   Schizophrenia
ID INDUCED OROFACIAL DYSKINESIA; MEMBRANE-LIPID PEROXIDATION; ANTIOXIDANT
   ENZYMES; ANTIPSYCHOTIC-DRUGS; BIPOLAR DISORDER; SCHIZOPHRENIA;
   EXPRESSION; OLANZAPINE; HEPATOTOXICITY; DYSREGULATION
AB Antipsychotics remain the standard of care for individuals with schizophrenia, despite their association with adverse effects including extrapyramidal symptoms, metabolic syndrome and agranulocytosis. While the biological mechanisms underlying these side effects remain unresolved, it has been proposed that oxidative stress may play a role in their development. The aim of this study was to evaluate markers of oxidative stress associated with first- and second-generation antipsychotics, focusing on protein and lipid oxidation and expression of the antioxidant proteins peroxiredoxin-2 and peroxiredoxin-6. Following 28-day administration of haloperidol, clozapine or saline to adult rats, brain grey matter, white matter, serum and liver samples were obtained and lipid peroxidation, protein oxidation, peroxiredoxin-2 and peroxiredoxin-6 levels quantified. In grey matter, peroxiredoxin-6 was significantly increased in the haloperidol-exposed animals, with a trend towards increased lipid peroxidation also observed in this. group. In liver, lipid peroxidation was increased in the clozapine-exposed animals, with a similar trend noted in the haloperidol group. Antipsychotics did not produce significant changes in serum or white matter. Our results suggest that haloperidol and clozapine may induce oxidative stress in brain and liver, respectively, consistent with the documented adverse effects of these agents. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
C1 [Andreazza, Ana C.; Barakauskas, Vilte E.; Fazeli, Salar; Feresten, Abigail; Shao, Li; Wei, Vivien; Wu, Che Hsuan; Beasley, Clare L.] Univ British Columbia, Dept Psychiat, Vancouver, BC V5Z 1M9, Canada.
   [Barr, Alasdair M.] Univ British Columbia, Dept Anaesthesiol Pharmacol & Therapeut, Vancouver, BC V5Z 1M9, Canada.
C3 University of British Columbia; University of British Columbia
RP Beasley, CL (corresponding author), BC Mental Hlth & Addict Res Inst, A3-115-938 West 28th Ave, Vancouver, BC V5Z 4H4, Canada.
EM cbeasley@mail.ubc.ca
RI ; Andreazza, Ana Cristina/P-8562-2018
OI Beasley, Clare/0000-0001-5919-7838; Barakauskas,
   Vilte/0000-0002-6909-0513; Andreazza, Ana Cristina/0000-0002-4323-7273;
   Barr, Alasdair/0000-0002-3407-1574
FU Mind Foundation of BC; Michael Smith Foundation for Health Research;
   Canadian Institutes of Health Research [81112]
FX This work was supported by the Mind Foundation of BC, the Michael Smith
   Foundation for Health Research and the Canadian Institutes of Health
   Research (#81112). The sponsors played no role in study design,
   collection, analysis and interpretation of data, the writing of the
   report, or in the decision to submit the article for publication.
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NR 47
TC 25
Z9 27
U1 0
U2 15
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0304-3940
EI 1872-7972
J9 NEUROSCI LETT
JI Neurosci. Lett.
PD MAR 30
PY 2015
VL 591
BP 36
EP 40
DI 10.1016/j.neulet.2015.02.028
PG 5
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA CE4FO
UT WOS:000351786700008
PM 25684243
DA 2025-06-11
ER

PT J
AU Oyovwi, MO
   Chijiokwu, EA
   Ben-Azu, B
   Atere, AD
   Joseph, UG
   Ogbutor, UG
   Udi, OA
AF Oyovwi, Mega Obukohwo
   Chijiokwu, Ejime A.
   Ben-Azu, Benneth
   Atere, Adedeji David
   Joseph, Uchechukwu Gregory
   Ogbutor, Udoji Godsday
   Udi, Onoriode Andrew
TI Potential Roles of Natural Antioxidants in Modulating Neurodegenerative
   Disease Pathways
SO MOLECULAR NEUROBIOLOGY
LA English
DT Review; Early Access
DE Neurodegenerative diseases; Antioxidants; Oxidative stress;
   Neuroprotection; Dietary interventions; Flavonoids; Polyphenols;
   Inflammation; Alzheimer's disease; Parkinson's disease
ID CORONARY-HEART-DISEASE; OXIDATIVE STRESS; METABOLIC SYNDROME; DEFEAT
   STRESS; LUNG-CANCER; SUPPLEMENTATION; BIOAVAILABILITY; RISK; ALZHEIMERS;
   MICE
AB Neurodegenerative diseases, including Alzheimer's, Parkinson's, and amyotrophic lateral sclerosis, are increasingly prevalent among aging populations. Oxidative stress contributes to these diseases, leading to cellular damage and neuronal death. Natural antioxidants are being explored as preventive measures. This study aims to assess the effectiveness of natural antioxidants in delaying the onset or progression of neurodegenerative diseases by identifying their specific mechanisms of action. A comprehensive review of existing literature was conducted, focusing on studies that examine the role of natural antioxidants in neuroprotection. Key natural antioxidants, including flavonoids, polyphenls, vitamins C and E, and omega-3 fatty acids, were reviewed and analyzed for their bioavailability, mechanisms of action, and outcomes in both in vitro and in vivo studies. Additionally, clinical trials involving human subjects were considered to provide insights into the translational implications of antioxidant consumption. The findings suggest that several natural antioxidants exhibit neuroprotective properties by modulating oxidative stress, reducing inflammation, and promoting neuronal survival. For instance, flavonoids such as quercetin and resveratrol have shown promise in enhancing cognitive function and mitigating the pathophysiological alterations associated with neurodegeneration. In clinical studies, higher intakes of dietary antioxidants were correlated with a reduced risk of developing neurodegenerative disorders. Natural antioxidants offer potential for preventing neurodegenerative diseases by counteracting oxidative stress and maintaining cellular integrity. Overall, our report recommends that further research is needed to optimize dosages and understand their long-term benefits.
C1 [Oyovwi, Mega Obukohwo] Delta State Univ Sci & Technol, Fac Basic Med Sci, Dept Human Physiol, Ozoro, Delta, Nigeria.
   [Chijiokwu, Ejime A.; Ogbutor, Udoji Godsday] Delta State Univ, Dept Physiol, Abraka, Delta, Nigeria.
   [Ben-Azu, Benneth] Delta State Univ, Coll Hlth Sci, Fac Basic Med Sci, Dept Pharmacol,DELSU Joint Canada Israel Neurosci, Abraka, Delta, Nigeria.
   [Atere, Adedeji David] Osun State Univ, Coll Hlth Sci, Dept Med Lab Sci, Osogbo, Nigeria.
   [Atere, Adedeji David] Sefako Makgatho Hlth Sci Univ, Neurotoxicol Lab, Molotlegi St,Ga Rankuwa Zone 1, ZA-0208 Ga Rankuwa, South Africa.
   [Joseph, Uchechukwu Gregory] Adeleke Univ, Fac Basic Med Sci, Dept Med Lab Sci, Ede, Osun, Nigeria.
   [Udi, Onoriode Andrew] Fed Univ Otuoke, Dept Human Anat, Yenagoa, Bayelsa, Nigeria.
C3 Sefako Makgatho Health Sciences University
RP Oyovwi, MO (corresponding author), Delta State Univ Sci & Technol, Fac Basic Med Sci, Dept Human Physiol, Ozoro, Delta, Nigeria.
EM megalect@gmail.com; julicambel@gmail.com; pharmben4ever@yahoo.com;
   adedeji.atere@uniosun.edu.ng; onosinandy@gmail.com; gregjoe07@gmail.com;
   gcclinics@yahoo.com
RI Obukohwo, Oyovwi/GRO-1623-2022; Atere, Adedeji/GRE-8275-2022
OI Atere, Adedeji David/0000-0002-8802-3762
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NR 238
TC 0
Z9 0
U1 5
U2 5
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0893-7648
EI 1559-1182
J9 MOL NEUROBIOL
JI Mol. Neurobiol.
PD 2025 APR 9
PY 2025
DI 10.1007/s12035-025-04874-w
EA APR 2025
PG 31
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 1DQ7W
UT WOS:001462542200001
PM 40202704
DA 2025-06-11
ER

PT J
AU Chang, E
   Chang, JS
   Kong, ID
   Baik, SK
   Kim, MY
   Park, KS
AF Chang, Eunha
   Chang, Jae Seung
   Kong, In Deok
   Baik, Soon Koo
   Kim, Moon Young
   Park, Kyu-Sang
TI Multidimensional Biomarker Analysis Including Mitochondrial Stress
   Indicators for Nonalcoholic Fatty Liver Disease
SO GUT AND LIVER
LA English
DT Review
DE Key Words; Non-alcoholic fatty liver disease; Biomarkers; Mitochondrial
   stress; Fibroblast growth factor 21; Growth differentiation factor 15
ID MAGNETIC-RESONANCE ELASTOGRAPHY; DIFFERENTIATION FACTOR 15; SERUM LEPTIN
   LEVELS; GROWTH-FACTOR AGF; CLINICAL SCORING SYSTEM; BINDING-PROTEIN 4;
   INSULIN-RESISTANCE; NONINVASIVE DIAGNOSIS; TNF-ALPHA; METABOLIC SYNDROME
AB Nonalcoholic fatty liver disease (NAFLD) is accompanied by a complex and multifactorial pathogenesis with sequential progressions from inflammation to fibrosis and then to cancer. This heterogeneity interferes with the development of precise diagnostic and prognostic strategies for NAFLD. The current approach for the diagnosis of simple steatosis, steatohepatitis, and cirrhosis mainly consists of ultrasonography, magnetic resonance imaging, elastography, and various serological analyses. However, individual dry and wet biomarkers have limitations demanding an integrative approach for the assessment of disease progression. Here, we review diagnostic strategies for simple steatosis, steatohepatitis and hepatic fibrosis, followed by potential biomarkers associated with fat accumulation and mitochondrial stress. For mitochondrial stress indicators, we focused on fibroblast growth factor 21 (FGF21), growth differentiation factor 15 (GDF15), angiopoietin-related growth factor and mitochondrial-derived peptides. Each biomarker may not strongly indicate the severity of steatosis or steatohepatitis. Instead, multidimensional analysis of different groups of biomarkers based on pathogenic mechanisms may provide decisive diagnostic/prognostic information to develop a therapeutic plan for patients with NAFLD. For this purpose, mitochondrial stress indicators, such as FGF21 or GDF15, could be an important component in the multiplexed and contextual interpretation of NAFLD. Further validation of the integrative evaluation of mitochondrial stress indicators combined with other biomarkers is needed in the diagnosis/prognosis of NAFLD. (Gut Liver, Published online August 24, 2021)
C1 [Chang, Eunha; Kong, In Deok; Park, Kyu-Sang] Yonsei Univ, Wonju Coll Med, Dept Physiol, Wonju, South Korea.
   [Chang, Eunha; Chang, Jae Seung; Baik, Soon Koo; Kim, Moon Young; Park, Kyu-Sang] Yonsei Univ, Wonju Coll Med, Mitohormesis Res Ctr, Wonju, South Korea.
   [Baik, Soon Koo; Kim, Moon Young] Yonsei Univ, Wonju Coll Med, Dept Internal Med, Wonju, South Korea.
C3 Yonsei University; Yonsei University; Yonsei University
RP Park, KS (corresponding author), Yonsei Univ, Wonju Coll Med, Dept Physiol, Wonju, South Korea.; Kim, MY; Park, KS (corresponding author), Yonsei Univ, Wonju Coll Med, Mitohormesis Res Ctr, Wonju, South Korea.; Kim, MY (corresponding author), Yonsei Univ, Wonju Coll Med, Dept Internal Med, Wonju, South Korea.
EM drkimmy@yonsei.ac.kr; qsang@yonsei.ac.kr
RI Chang, Jae Seung/JED-9976-2023
OI Park, Kyu-Sang/0000-0003-0322-9807; Chang, Jae
   Seung/0000-0002-4047-1128; Chang, Eunha/0000-0002-8510-9368
FU Medical Research Center Program [2017R1A5A2015369]; Bio & Medical
   Technology Development Program [NRF-2020M3A9D8039920]; NRF Grant from
   the Ministry of Sci-ence and ICT, Republic of Korea [2019R1A2C2084604]
FX This work was supported by the Medical Research Center Program
   (2017R1A5A2015369) , Bio & Medical Technology Development Program
   (NRF-2020M3A9D8039920) , and NRF Grant (2019R1A2C2084604) from the
   Ministry of Sci-ence and ICT, Republic of Korea.
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NR 179
TC 4
Z9 5
U1 1
U2 9
PU EDITORIAL OFFICE GUT & LIVER
PI SEOUL
PA 305 LOTTE GOLD ROSE II, 890-59, DAECHI 4-DONG, GANGNAM-GU, SEOUL,
   135-839, SOUTH KOREA
SN 1976-2283
EI 2005-1212
J9 GUT LIVER
JI Gut Liver
PD MAR
PY 2022
VL 16
IS 2
BP 171
EP 189
DI 10.5009/gnl210106
EA AUG 2021
PG 19
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 5C1MD
UT WOS:000708899800001
PM 34420934
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Ren, L
   Wang, Q
   Chen, Y
   Ma, YZ
   Wang, DM
AF Ren, Lin
   Wang, Qian
   Chen, Yu
   Ma, Yanzhuo
   Wang, Dongmei
TI Involvement of MicroRNA-133a in the Protective Effect of Hydrogen
   Sulfide against Ischemia/Reperfusion-Induced Endoplasmic Reticulum
   Stress and Cardiomyocyte Apoptosis
SO PHARMACOLOGY
LA English
DT Article
DE MicroRNA-133a; Hydrogen sulfide; Ischemia/reperfusion; Endoplasmic
   reticulum stress; Cardiomyocyte apoptosis
ID ENHANCED EXPRESSION; METABOLIC SYNDROME; RAT MODEL; ISCHEMIA; INJURY;
   MOUSE; INFLAMMATION; MIR-1
AB Aim: Myocardial ischemia/reperfusion (I/R) injury is a severe trauma that cells undergo and is associated with cardiomyocyte apoptosis. Recently, miRNAs have been demonstrated to play an important role in cardiovascular biology and disease. However, whether the miR-133a and ER stress play a role in hydrogen sulfide (H2S) protection of cardiomyocytes against I/R-induced apoptosis remains unclear. Methods: The neonatal cardiomyocytes were prepared to be treated with H2S or transfected with miR-133a activator or miR-133a inhibitor, either separately or in combination. Non-treated cardiomyocytes served as control. The ER stress biomarker GRP78, CHOP, and eIF2 alpha expression levels were measured by Western blot. Cell apoptosis was assessed by flow cytometry after staining with the Annexin V-FITC. Proliferation was monitored by BrdU labeling, while cell migration and invasion were determined by Transwell assays. Results: Pretreatment of H2S and overexpression of miR-133a reversed I/R-induced ER stress and cardiomyocyte apoptosis in vitro and in vivo. The proliferation, migration, and invasion of cardiomyocytes were significantly increased by co-treatment with H2S and overexpression of miR-133a. Conclusion: These findings suggest the protective effect of miR-133a against I/R-induced ER stress and cardiomyocyte apoptosis and its enhancement of cell motility. Thus, cardioprotection by miR-133a overexpression provides a novel therapeutic approach to the treatment of ischemic heart diseases. (C) 2018 S. Karger AG, Basel
C1 [Ren, Lin] Hebei Med Univ, Shijiazhuang, Hebei, Peoples R China.
   [Wang, Qian] Qinhuangdao First Hosp, Dept Geriatr, Qinhuangdao, Peoples R China.
   [Chen, Yu; Ma, Yanzhuo; Wang, Dongmei] Bethune Int Peace Hosp, Dept Cardiol, Shijiazhuang 050000, Hebei, Peoples R China.
C3 Hebei Medical University
RP Wang, DM (corresponding author), Bethune Int Peace Hosp, Dept Cardiol, Shijiazhuang 050000, Hebei, Peoples R China.
EM Wangdongmeizhejdoc@163.com
RI Ren, Lin/AAX-5885-2021
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NR 32
TC 49
Z9 52
U1 0
U2 14
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0031-7012
EI 1423-0313
J9 PHARMACOLOGY
JI Pharmacology
PY 2019
VL 103
IS 1-2
BP 1
EP 9
DI 10.1159/000492969
PG 9
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA HM5XC
UT WOS:000459547600001
PM 30326468
DA 2025-06-11
ER

PT J
AU Santini, S Jr
   Tarantino, G
   Iezzi, A
   Alisi, A
   Balsano, C
AF Santini, Silvano Junior
   Tarantino, Giovanni
   Iezzi, Antonella
   Alisi, Anna
   Balsano, Clara
TI Copper-catalyzed dicarbonyl stress in NAFLD mice: protective effects of
   Oleuropein treatment on liver damage
SO NUTRITION & METABOLISM
LA English
DT Article
DE NAFLD; MAFLD; Oleuropein; Dicarbonilyl stress; Copper; Sex;
   Nutriaceutical compounds
ID SENSITIVE AMINE OXIDASE; FATTY LIVER; TRANSPORTING ATPASES;
   GLYOXALASE-II; METABOLISM; EXPRESSION; CTR1; NRF2; METHYLGLYOXAL; GENES
AB Background Nonalcoholic fatty liver disease (NAFLD) or more appropriately, metabolic associated fatty liver disease (MAFLD), is the hepatic manifestation of metabolic syndrome. An imbalance of copper homeostasis has been described in the progression of NAFLD/MAFLD toward NASH/MASH. We were interested in understanding whether the chelating activity of Oleuropein (Ole) was able to improve the copper accumulation and the related pro-oxidant and glycative damage in the liver of mice fed HFD. Methods Twelve C57BL/6J mice fed normal diet (ND) or high-fat diet (HFD) for 16 weeks and then thirty two female and male mice fed ND or HFD for 8 weeks adding Ole for the following 8 weeks were studied. Results Altered expression of copper-trafficking genes and proteins (CTR1, CTR2, ATP7B, COX17, CCS, and ATOX1) induced imbalance of copper homeostasis combined with an increase in dicarbonyl stress in the liver of HFD fed mice. Interestingly enough, glyoxalase system was improved by Ole administration and the Ole related protective effects differ in the two sexes of mice. Conclusions Our study highlights the role of the dicarbonyl stress in the pathogenesis of NAFLD and suggests Ole as a natural copper chelator to prevent the liver damage induced by methyglyoxal pathway derangement.
C1 [Santini, Silvano Junior; Iezzi, Antonella; Balsano, Clara] Univ Aquila, Dept Life Hlth & Environm Sci MESVA, Piazza S Salvatore Tommasi 1, I-67100 Laquila, Italy.
   [Santini, Silvano Junior; Balsano, Clara] Francesco Balsano Fdn, Via Giovanni Battista Martini 6, I-00198 Rome, Italy.
   [Tarantino, Giovanni] Univ Naples Federico II, Dept Clin Med & Surg, Med Sch Naples, Naples, Italy.
   [Alisi, Anna] Bambino Gesu Pediat Hosp, IRCCS, Res Unit Mol Genet Complex Phenotypes, Viale San Paolo 15, I-00146 Rome, Italy.
C3 University of L'Aquila; University of Naples Federico II; IRCCS Bambino
   Gesu
RP Balsano, C (corresponding author), Univ Aquila, Dept Life Hlth & Environm Sci MESVA, Piazza S Salvatore Tommasi 1, I-67100 Laquila, Italy.; Balsano, C (corresponding author), Francesco Balsano Fdn, Via Giovanni Battista Martini 6, I-00198 Rome, Italy.; Alisi, A (corresponding author), Bambino Gesu Pediat Hosp, IRCCS, Res Unit Mol Genet Complex Phenotypes, Viale San Paolo 15, I-00146 Rome, Italy.
EM anna.alisi@opbg.net; clara.balsano@univaq.it
RI Balsano, Clara/MCY-5404-2025; Alisi, Anna/A-6469-2010; Santini, Silvano
   Junior/S-5406-2016
OI Alisi, Anna/0000-0001-7241-6329; Santini, Silvano
   Junior/0000-0001-6577-5892; Balsano, Clara/0000-0002-9615-7031
FU Francesco Balsano Foundation (FFB) [2017/2018]
FX This work was supported by the Francesco Balsano Foundation (FFB Grant
   2017/2018).
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NR 77
TC 8
Z9 8
U1 2
U2 13
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1743-7075
J9 NUTR METAB
JI Nutr. Metab.
PD FEB 11
PY 2022
VL 19
IS 1
AR 9
DI 10.1186/s12986-022-00641-z
PG 16
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA YX6IE
UT WOS:000754203500001
PM 35148806
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Lytwyn, M
   Fallah-Rad, N
   Walker, J
   Bohonis, S
   Hussain, F
   Barac, I
   Jassal, DS
AF Lytwyn, Matthew
   Fallah-Rad, Nazanin
   Walker, Jonathan
   Bohonis, Sheena
   Hussain, Farrukh
   Barac, Ivan
   Jassal, Davinder S.
TI The Utility of Dobutamine Stress Echocardiography for the Diagnosis of
   Coronary Artery Disease in the HIV Population
SO ECHOCARDIOGRAPHY-A JOURNAL OF CARDIOVASCULAR ULTRASOUND AND ALLIED
   TECHNIQUES
LA English
DT Article
DE stress echocardiography; human immunodeficiency virus; coronary
   angiography
ID INFECTED PATIENTS; ANTIRETROVIRAL THERAPY; ATHEROSCLEROTIC PLAQUES;
   CARDIOVASCULAR-DISEASE; PROTEASE INHIBITORS; METABOLIC SYNDROME;
   ATROPINE; MANIFESTATIONS; RISK; ECHO
AB Background: The introduction of highly active antiretroviral therapy (HAART) has increased human immunodeficiency virus (HIV) patient longevity by 10-15 years. This increased longevity has habituated new cardiovascular complications, in particular, accelerated coronary artery disease (CAD). Although dobutamine stress echocardiography (DSE) is a highly sensitive and specific test for the noninvasive detection of underlying CAD in the general population, its utility in the HIV population remains unknown. Objective: The objective of the current study was to assess the validity of DSE for the noninvasive detection of underlying symptomatic CAD in the HIV population using cardiac catheterization as the gold standard. Methods and results: A total of 40 HIV positive patients (mean 49 +/- 8 years; 31 males) between 2006 and 2009 inclusively underwent routine DSE and coronary angiography. A positive stress echo with new wall motion abnormalities was detected in 9 (23%) individuals. Coronary angiography, following DSE, detected obstructive CAD in 12 (30%) individuals. For the diagnosis of obstructive CAD, DSE has a sensitivity of 67%, specificity of 97%, positive predictive value (PPV) of 89%, and negative predictive value (NPV) of 87%. Conclusion: In this select HIV population, DSE was highly specific for the noninvasive detection of obstructive CAD. (Echocardiography 2010;27:1228-1232).
C1 [Lytwyn, Matthew; Fallah-Rad, Nazanin; Walker, Jonathan; Bohonis, Sheena; Jassal, Davinder S.] Univ Manitoba, St Boniface Gen Hosp, Res Ctr, Inst Cardiovasc Sci, Winnipeg, MB, Canada.
   [Hussain, Farrukh; Barac, Ivan; Jassal, Davinder S.] Univ Manitoba, Cardiol Sect, Dept Internal Med, Winnipeg, MB, Canada.
   [Jassal, Davinder S.] Univ Manitoba, Dept Radiol, Winnipeg, MB, Canada.
C3 University of Manitoba; Saint Boniface Hospital; Children's Hospital
   Research Institute of Manitoba; University of Manitoba; University of
   Manitoba
RP Jassal, DS (corresponding author), St Boniface Gen Hosp, Dept Cardiac Sci, Bergen Cardiac Care Ctr, Div Cardiol, Rm Y3010,409 Tache Ave, Winnipeg, MB R2H 2A6, Canada.
EM djassal@sbgh.mb.ca
RI ; Walker, Jonathan/O-4736-2017
OI Jassal, Davinder S/0000-0002-3639-9047; Walker,
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NR 45
TC 0
Z9 0
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0742-2822
EI 1540-8175
J9 ECHOCARDIOGR-J CARD
JI Echocardiography-J. Cardiovasc. Ultrasound Allied Tech.
PD NOV
PY 2010
VL 27
IS 10
BP 1228
EP 1232
DI 10.1111/j.1540-8175.2010.01218.x
PG 5
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 684XK
UT WOS:000284588400018
PM 20584060
DA 2025-06-11
ER

PT J
AU Jalali, M
   Mahmoodi, M
   Moosavian, SP
   Jalali, R
   Ferns, G
   Mosallanezhad, A
   Imanieh, MH
   Mosallanezhad, Z
AF Jalali, Mohammad
   Mahmoodi, Marzieh
   Moosavian, Seyedeh Parisa
   Jalali, Ronak
   Ferns, Gordon
   Mosallanezhad, Abdolhamid
   Imanieh, Mohammad Hadi
   Mosallanezhad, Zahra
TI The effects of ginger supplementation on markers of inflammatory and
   oxidative stress: A systematic review and meta-analysis of clinical
   trials
SO PHYTOTHERAPY RESEARCH
LA English
DT Review
DE Ginger; Inflammation; Meta-analysis; Oxidative stress; Zingiber
ID ZINGIBER-OFFICINALE-ROSCOE; NF-KAPPA-B; METABOLIC SYNDROME; EXPRESSION;
   OBESITY
AB The present systematic review and meta-analysis was conducted to investigate the effects of ginger supplementation on markers of inflammatory and oxidative stress. PubMed, Embase, Scopus, and Web of Science were systematically searched to identify relevant clinical trials evaluating the effects of ginger on serum CRP (C-reactive protein), TNF-alpha (tumor necrosis factor-alpha), IL-6 (interleukin-6), PGE2 (prostaglandin E2), TAC (total antioxidant capacity), and MDA (malondialdehyde) from inception up to September 2019. Mean difference and 95% confidence intervals were pooled using a random-effects model. Potential publication bias was assessed using visual inspection of funnel plot and Egger's weighted regression tests. After excluding irrelevant records, 20 full-text articles that included 25 separate studies were included to the meta-analysis. Pooled results of this study indicated a statistically significant effect of ginger on serum CRP, TNF-alpha, IL-6, TAC, and MDA levels following ginger supplementation in compared to the controls. Also, the effects of ginger on serum PGE2 was marginally significant. Moreover, the high heterogeneity was disappeared in subgroup analysis performed by age, duration, dosage, and quality. This current analysis indicates that ginger supplementation has a significant effects on serum inflammatory and oxidative stress markers.
C1 [Jalali, Mohammad; Mahmoodi, Marzieh] Shiraz Univ Med Sci, Student Res Comm, Shiraz, Iran.
   [Jalali, Mohammad; Moosavian, Seyedeh Parisa; Mosallanezhad, Zahra] Shiraz Univ Med Sci, Sch Nutr & Food Sci, Nutr Res Ctr, Razi Ave, Shiraz 7153675541, Iran.
   [Moosavian, Seyedeh Parisa] Isfahan Univ Med Sci, Sch Nutr & Food Sci, Dept Clin Nutr, Food Secur Res Ctr, Esfahan, Iran.
   [Jalali, Ronak] Golestan Univ Med Sci, Student Res Comm, Gorgan, Golestan, Iran.
   [Ferns, Gordon] Brighton & Sussex Med Sch, Div Med Educ, Brighton, E Sussex, England.
   [Mosallanezhad, Abdolhamid] Shiraz Univ Med Sci, Khalili Educ & Treatment Ctr, Shiraz, Iran.
   [Imanieh, Mohammad Hadi] Shiraz Univ Med Sci, Gastroenterohepatol Res Ctr, Shiraz, Iran.
C3 Shiraz University of Medical Science; Shiraz University of Medical
   Science; Isfahan University of Medical Sciences; Golestan University of
   Medical Sciences; University of Sussex; University of Brighton; Shiraz
   University of Medical Science; Shiraz University of Medical Science
RP Mosallanezhad, Z (corresponding author), Shiraz Univ Med Sci, Sch Nutr & Food Sci, Nutr Res Ctr, Razi Ave, Shiraz 7153675541, Iran.
EM zahra.mosallanj@gmail.com
RI Imanieh, Mohammad/AAF-7426-2019; Jalali, Mohammad/ABC-6882-2020;
   Moosavian, Seyedeh/AAV-7757-2020
OI Moosavian, Seyedeh Parisa/0000-0002-5990-1984; Mahmoodi,
   Marzieh/0009-0002-9411-4115; Jalali, Mohammad/0000-0001-8133-3875
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NR 51
TC 40
Z9 40
U1 4
U2 19
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0951-418X
EI 1099-1573
J9 PHYTOTHER RES
JI Phytother. Res.
PD AUG
PY 2020
VL 34
IS 8
BP 1723
EP 1733
DI 10.1002/ptr.6638
PG 11
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA MV8PF
UT WOS:000556612000001
PM 32147845
OA Green Accepted, Green Submitted
DA 2025-06-11
ER

PT J
AU Xu, XJ
   Apovian, C
   Hess, D
   Carmine, B
   Saha, A
   Ruderman, N
AF Xu, X. Julia
   Apovian, Caroline
   Hess, Donald
   Carmine, Brian
   Saha, Asish
   Ruderman, Neil
TI Improved Insulin Sensitivity 3 Months After RYGB Surgery Is Associated
   With Increased Subcutaneous Adipose Tissue AMPK Activity and Decreased
   Oxidative Stress
SO DIABETES
LA English
DT Article
ID GASTRIC BYPASS-SURGERY; BARIATRIC SURGERY; WEIGHT-LOSS; METABOLIC
   SYNDROME; PROTEIN-KINASE; MALONYL-COA; RESISTANCE; HUMANS; HOMEOSTASIS;
   GLUCOSE
AB Morbidly obese individuals are predisposed to a wide range of disorders, including type 2 diabetes, atherosclerotic cardiovascular disease, fatty liver disease, and certain cancers. Remarkably, all of these disorders can be improved or prevented by Roux-en-Y gastric bypass (RYGB) surgery. We have reported that decreased AMPK activity, together with increased oxidative stress and inflammation in adipose tissue, is associated with insulin resistance in morbidly obese bariatric surgery patients. In the current study, we assessed how these parameters are affected by RYGB surgery. Eleven patients (average age of 46 +/- 4 years) were studied immediately prior to surgery and 3 months postoperatively. We measured subcutaneous adipose tissue AMPK phosphorylation (threonine 172, an index of its activation), malonyl-CoA content, protein carbonylation (a marker of oxidative stress), plasma adiponectin, and mRNA expression of several inflammatory cytokines. After surgery, AMPK activity increased 3.5-fold and oxidative stress decreased by 50% in subcutaneous adipose tissue. In addition, malonyl-CoA levels were reduced by 80%. Furthermore, patients had improvements in their BMI and insulin sensitivity (HOMA) and had increased circulating high-molecular weight adiponectin and decreased fasting plasma insulin levels. In contrast, the expression of inflammatory markers in subcutaneous adipose tissue was unchanged postoperatively, although plasma CRP was diminished by 50%.
C1 [Xu, X. Julia; Apovian, Caroline; Saha, Asish; Ruderman, Neil] Boston Univ, Sch Med, Diabet & Metab Unit, Endocrinol Sect,Dept Med, Boston, MA 02118 USA.
   [Apovian, Caroline] Boston Univ, Sch Med, Nutr & Weight Management Ctr, Boston, MA 02118 USA.
   [Hess, Donald; Carmine, Brian] Boston Univ, Sch Med, Dept Surg, Boston, MA 02118 USA.
C3 Boston University; Boston University; Boston University
RP Xu, XJ (corresponding author), Boston Univ, Sch Med, Diabet & Metab Unit, Endocrinol Sect,Dept Med, Boston, MA 02118 USA.
EM juliaxu@bu.edu
FU National Institutes of Health [R01-DK-19514]
FX This work is supported by the National Institutes of Health
   (R01-DK-19514 to N.R.).
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NR 24
TC 47
Z9 49
U1 0
U2 9
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0012-1797
EI 1939-327X
J9 DIABETES
JI Diabetes
PD SEP
PY 2015
VL 64
IS 9
BP 3155
EP 3159
DI 10.2337/db14-1765
PG 5
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA CP9AE
UT WOS:000360185300014
PM 26001396
OA Green Published
DA 2025-06-11
ER

PT J
AU De Nicola, AF
   Meyer, M
   Guennoun, R
   Schumacher, M
   Hunt, H
   Belanoff, J
   de Kloet, ER
   Deniselle, MCG
AF De Nicola, Alejandro F.
   Meyer, Maria
   Guennoun, Rachida
   Schumacher, Michael
   Hunt, Hazel
   Belanoff, Joseph
   de Kloet, E. Ronald
   Gonzalez Deniselle, Maria Claudia
TI Insights into the Therapeutic Potential of Glucocorticoid Receptor
   Modulators for Neurodegenerative Diseases
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE Wobbler mouse; amyotrophic lateral sclerosis; glucocorticoid receptor
   antagonist; neurodegeneration; neuroinflammation
ID AMYOTROPHIC-LATERAL-SCLEROSIS; TRANSGENIC MOUSE MODEL; SPINAL-CORD;
   AMYLOID-BETA; MINERALOCORTICOID RECEPTOR; SELECTIVE MODULATOR; METABOLIC
   SYNDROME; PLASMA-CORTISOL; WOBBLER MOUSE; STRESS
AB Glucocorticoids are crucial for stress-coping, resilience, and adaptation. However, if the stress hormones become dysregulated, the vulnerability to stress-related diseases is enhanced. In this brief review, we discuss the role of glucocorticoids in the pathogenesis of neurodegenerative disorders in both human and animal models, and focus in particular on amyotrophic lateral sclerosis (ALS). For this purpose, we used the Wobbler animal model, which mimics much of the pathology of ALS including a dysfunctional hypothalamic-pituitary-adrenal axis. We discuss recent studies that demonstrated that the pathological cascade characteristic for motoneuron degeneration of ALS is mimicked in the genetically selected Wobbler mouse and can be attenuated by treatment with the selective glucocorticoid receptor antagonist (GRA) CORT113176. In long-term treatment (3 weeks) GRA attenuated progression of the behavioral, inflammatory, excitatory, and cell-death-signaling pathways while increasing the survival signal of serine-threonine kinase (pAkt). The action mechanism of the GRA may be either by interfering with GR deactivation or by restoring the balance between pro- and anti-inflammatory signaling pathways driven by the complementary mineralocorticoid receptor (MR)- and GR-mediated actions of corticosterone. Accordingly, GR antagonism may have clinical relevance for the treatment of neurodegenerative diseases.
C1 [De Nicola, Alejandro F.; Meyer, Maria; Gonzalez Deniselle, Maria Claudia] Consejo Nacl Invest Cient & Tecn, Lab Neuroendocrine Biochem, Inst Biol & Med Expt, Obligado 2490, Buenos Aires 1428, DF, Argentina.
   [De Nicola, Alejandro F.] Univ Buenos Aires, Dept Human Biochem, Fac Med, Paraguay 2155, Buenos Aires 2155, DF, Argentina.
   [Guennoun, Rachida; Schumacher, Michael] U1195 Inserm, 80 Rue Gen Leclerc, Le Kremlin Bicetre 94276, France.
   [Guennoun, Rachida; Schumacher, Michael] Univ Paris Sud, 80 Rue Gen Leclerc, Le Kremlin Bicetre 94276, France.
   [Guennoun, Rachida; Schumacher, Michael] Univ Paris Saclay, 80 Rue Gen Leclerc, Le Kremlin Bicetre 94276, France.
   [Hunt, Hazel; Belanoff, Joseph] CORCEPT Therapeut, 149 Commonwealth Dr, Menlo Pk, CA 94025 USA.
   [de Kloet, E. Ronald] Leiden Univ, Div Endocrinol, Dept Internal Med, Med Ctr, Albinusdreef 2, Leiden 2333 ZA, Netherlands.
   [Gonzalez Deniselle, Maria Claudia] Univ Buenos Aires, Dept Physiol, Fac Med, Paraguay 2155, Buenos Aires 1425, DF, Argentina.
C3 Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET);
   Institute of Biology & Experimental Medicine; University of Buenos
   Aires; Institut National de la Sante et de la Recherche Medicale
   (Inserm); Universite Paris Saclay; Universite Paris Saclay; Leiden
   University - Excl LUMC; Leiden University; Leiden University Medical
   Center (LUMC); University of Buenos Aires
RP De Nicola, AF (corresponding author), Consejo Nacl Invest Cient & Tecn, Lab Neuroendocrine Biochem, Inst Biol & Med Expt, Obligado 2490, Buenos Aires 1428, DF, Argentina.; De Nicola, AF (corresponding author), Univ Buenos Aires, Dept Human Biochem, Fac Med, Paraguay 2155, Buenos Aires 2155, DF, Argentina.
EM alejandrodenicola@gmail.com; mariameyer1981@gmail.com;
   rachida.guennoun@inserm.fr; michael.schumacher@inserm.fr;
   hhunt@corcept.com; jbelanoff@corcept.com; erdekloet@gmail.com;
   gonzalezdeniselle@gmail.com
RI de Kloet, Edo/H-3278-2011; Guennoun, Rachida/F-2420-2011; Schumacher,
   Michael/G-3581-2013
OI Gonzalez Deniselle, Maria Claudia/0000-0001-9121-0019; de Kloet,
   Ron/0000-0001-9176-1830; Schumacher, Michael/0000-0001-6117-5371
FU National Research Council of Argentina (PIP 2017 2019)
   [11220170100002CO]; Ministry of Health and Technology of Argentina (PICT
   2017) [1150]; University of Buenos Aires [20020170100224BA]; Rene Baron
   Foundation of Argentina; Williams Foundation of Argentina; Roemmers
   Foundation of Argentina; Corcept Therapeutics, Menlo Park, Ca. USA
FX Work reported in this review was supported by the National Research
   Council of Argentina (PIP 2017 2019 11220170100002CO), the Ministry of
   Health and Technology of Argentina (PICT 2017 No 1150), the University
   of Buenos Aires 20020170100224BA), Rene Baron, Williams and Roemmers
   Foundations of Argentina, and Corcept Therapeutics, Menlo Park, Ca. USA.
   These funding sources did not have a role in the collection, analysis or
   interpretation of data, in the writing and in the decision to publish
   the results of the present investigation.
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NR 87
TC 28
Z9 28
U1 0
U2 14
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD MAR
PY 2020
VL 21
IS 6
AR 2137
DI 10.3390/ijms21062137
PG 16
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA LJ0UU
UT WOS:000529890200233
PM 32244957
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Sohet, FM
   Neyrinck, AM
   Dewulf, EM
   Bindels, LB
   Portois, L
   Malaisse, WJ
   Carpentier, YA
   Cani, PD
   Delzenne, NM
AF Sohet, Florence M.
   Neyrinck, Audrey M.
   Dewulf, Evelyne M.
   Bindels, Laure B.
   Portois, Laurence
   Malaisse, Willy J.
   Carpentier, Yvon A.
   Cani, Patrice D.
   Delzenne, Nathalie M.
TI Lipid peroxidation is not a prerequisite for the development of obesity
   and diabetes in high-fat-fed mice
SO BRITISH JOURNAL OF NUTRITION
LA English
DT Article
DE High-fat feeding; Lipid peroxidation; Inflammation; Vitamin E; Diabetes
ID INSULIN-RESISTANCE; OXIDATIVE STRESS; METABOLIC SYNDROME; UNIFYING
   HYPOTHESIS; VITAMIN-E; DIET; INFLAMMATION; ENDOTOXEMIA; SENSITIVITY;
   ACIDS
AB The mechanism, by which a high-fat (HF) diet could impair glucose metabolism, is not completely understood but could be related to inflammation, lipotoxicity and oxidative stress. Lipid peroxides have been proposed as key mediators of intracellular metabolic response. The purpose of the present study was to analyse, in mice fed with a HF diet, the possible association between obesity and glucose tolerance on the one hand, and between oxidative stress and lipid peroxidation on the other hand. The present results show that a HF diet (70% energy as fat), v. a high-carbohydrate chow diet (control), increases body weight and fat mass development, and impairs glycaemia and insulinaemia within 4 weeks. It also promotes the expression of NADPH oxidase in the liver - signing both oxidative and inflammatory stress - but decreases thiobarbituric acid-reactive substances content in the liver as well as in epididymal, subcutaneous and visceral adipose tissues. HF diet, with elevated vitamin E content, induces high concentration of alpha-tocopherol in liver and adipose tissues, which contributes to the protection against lipid peroxidation. Thus, lipid peroxidation in key organs is not necessarily related to the development of metabolic disorders associated with diabetes and obesity.
C1 [Sohet, Florence M.; Neyrinck, Audrey M.; Dewulf, Evelyne M.; Bindels, Laure B.; Cani, Patrice D.; Delzenne, Nathalie M.] Catholic Univ Louvain, Unit Pharmacokinet Metab Nutr & Toxicol, Louvain Drug Res Inst, B-1200 Brussels, Belgium.
   [Portois, Laurence; Malaisse, Willy J.; Carpentier, Yvon A.] Univ Libre Bruxelles, Expt Surg Lab, Brussels, Belgium.
C3 Universite Catholique Louvain; Universite Libre de Bruxelles
RP Delzenne, NM (corresponding author), Catholic Univ Louvain, Unit Pharmacokinet Metab Nutr & Toxicol, Louvain Drug Res Inst, Av E Mounier 73-69, B-1200 Brussels, Belgium.
EM nathalie.delzenne@uclouvain.be
RI Bindels, Laure/T-7846-2019; Neyrinck, Audrey/AAE-7929-2019; Delzenne,
   Nathalie/AAC-4628-2019; Cani, Patrice D./M-8055-2016
OI Bindels, Laure B./0000-0003-3747-3234; Cani, Patrice
   D./0000-0003-2040-2448; Neyrinck, Audrey/0000-0002-9435-3338; Delzenne,
   Nathalie/0000-0003-2115-6082
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NR 40
TC 23
Z9 26
U1 0
U2 3
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1145
EI 1475-2662
J9 BRIT J NUTR
JI Br. J. Nutr.
PD AUG 14
PY 2009
VL 102
IS 3
BP 462
EP 469
DI 10.1017/S0007114508191243
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 482YB
UT WOS:000268925500019
PM 19161640
OA Bronze
DA 2025-06-11
ER

PT J
AU Fraga, NR
   Minaeian, N
   Kim, MS
AF Fraga, Nicole R.
   Minaeian, Nare
   Kim, Mimi S.
TI Congenital Adrenal Hyperplasia
SO PEDIATRICS IN REVIEW
LA English
DT Article
ID BONE-MINERAL DENSITY; DEHYDROGENASE-DEFICIENCY; ADRENOMEDULLARY
   FUNCTION; YOUNG-ADULTS; RISK-FACTORS; REST TUMORS; CHILDREN;
   HYPOGLYCEMIA; INFANTS; ILLNESS
AB We describe congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency, which is the most common primary adrenal insufficiency in children and adolescents. In this comprehensive review of CAH, we describe presentations at different life stages depending on disease severity. CAH is characterized by androgen excess secondary to impaired steroidogenesis in the adrenal glands. Diagnosis of CAH is most common during infancy with elevated 17-hydroxyprogesterone levels on the newborn screen in the United States. However, CAH can also present in childhood, with late-onset symptoms such as premature adrenarche, growth acceleration, hirsutism, and irregular menses. The growing child with CAH is treated with hydrocortisone for glucocorticoid replacement, along with increased stress doses for acute illness, trauma, and procedures. Mineralocorticoid and salt replacement may also be necessary. Although 21-hydroxylase deficiency is the most common type of CAH, there are other rare types, such as 11 beta-hydroxylase and 3 beta-hydroxysteroid dehydrogenase deficiency. In addition, classic CAH is associated with long-term comorbidities, including cardiometabolic risk factors, impaired cognitive function, adrenal rest tumors, and bone health effects. Overall, early identification and treatment of CAH is important for the pediatric patient.
C1 [Fraga, Nicole R.] Childrens Hosp Los Angeles, Ctr Endocrinol Diabet & Metab, Los Angeles, CA 90027 USA.
   [Minaeian, Nare] Univ Southern Calif, Keck Sch Med, Los Angeles, CA USA.
   [Kim, Mimi S.] Childrens Hosp Los Angeles, Saban Res Inst, Los Angeles, CA USA.
C3 Children's Hospital Los Angeles; University of Southern California;
   Children's Hospital Los Angeles
RP Fraga, NR (corresponding author), Childrens Hosp Los Angeles, Ctr Endocrinol Diabet & Metab, Los Angeles, CA 90027 USA.
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SN 0191-9601
EI 1526-3347
J9 PEDIATR REV
JI Pediatr. Rev.
PD FEB
PY 2024
VL 45
IS 2
BP 74
EP 84
DI 10.1542/pir.2022-005617
PG 11
WC Pediatrics
WE Emerging Sources Citation Index (ESCI)
SC Pediatrics
GA WM3J6
UT WOS:001255244400002
PM 38296783
DA 2025-06-11
ER

PT J
AU Xie, F
   Song, YF
   Yi, Y
   Jiang, X
   Ma, SW
   Ma, C
   Li, JY
   Zhanghuang, Z
   Liu, MY
   Zhao, PX
   Ma, XM
AF Xie, Fei
   Song, Yifei
   Yi, Yang
   Jiang, Xue
   Ma, Shiwen
   Ma, Chen
   Li, Junyu
   Zhanghuang, Ziyi
   Liu, Mengyu
   Zhao, Pengxiang
   Ma, Xuemei
TI Therapeutic Potential of Molecular Hydrogen in Metabolic Diseases from
   Bench to Bedside
SO PHARMACEUTICALS
LA English
DT Review
DE molecular hydrogen (H-2); metabolic diseases; oxidative stress;
   pre-clinical studies; clinical trials
ID SENSITIVE K+ CHANNELS; FATTY LIVER-DISEASE; RICH WATER; OXIDATIVE
   STRESS; CHOLESTEROL LEVELS; DIABETES-MELLITUS; BODY-COMPOSITION; REDUCED
   WATER; SALINE; ANTIOXIDANT
AB Oxidative stress and chronic inflammation have been implicated in the pathophysiology of metabolic diseases, including diabetes mellitus (DM), metabolic syndrome (MS), fatty liver (FL), atherosclerosis (AS), and obesity. Molecular hydrogen (H-2) has long been considered a physiologically inert gas. In the last two decades, accumulating evidence from pre-clinical and clinical studies has indicated that H-2 may act as an antioxidant to exert therapeutic and preventive effects on various disorders, including metabolic diseases. However, the mechanisms underlying the action of H-2 remain unclear. The purpose of this review was to (1) provide an overview of the current research on the potential effects of H-2 on metabolic diseases; (2) discuss the possible mechanisms underlying these effects, including the canonical anti-oxidative, anti-inflammatory, and anti-apoptotic effects, as well as suppression of ER stress, activation of autophagy, improvement of mitochondrial function, regulation of gut microbiota, and other possible mechanisms. The potential target molecules of H-2 will also be discussed. With more high-quality clinical trials and in-depth mechanism research, it is believed that H-2 will eventually be applied to clinical practice in the future, to benefit more patients with metabolic disease.
C1 [Xie, Fei; Song, Yifei; Yi, Yang; Jiang, Xue; Ma, Shiwen; Ma, Chen; Li, Junyu; Zhanghuang, Ziyi; Liu, Mengyu; Zhao, Pengxiang; Ma, Xuemei] Beijing Univ Technol, Fac Environm & Life, Beijing 100124, Peoples R China.
   [Xie, Fei; Song, Yifei; Yi, Yang; Jiang, Xue; Ma, Shiwen; Ma, Chen; Li, Junyu; Zhanghuang, Ziyi; Liu, Mengyu; Zhao, Pengxiang; Ma, Xuemei] Beijing Mol Hydrogen Res Ctr, Beijing 100124, Peoples R China.
C3 Beijing University of Technology
RP Ma, XM (corresponding author), Beijing Univ Technol, Fac Environm & Life, Beijing 100124, Peoples R China.; Ma, XM (corresponding author), Beijing Mol Hydrogen Res Ctr, Beijing 100124, Peoples R China.
EM xiefei990815@bjut.edu.cn; xmma@bjtu.edu.cn
RI Zhao, Pengxiang/JVP-1750-2024; Xie, Fei/I-9766-2016; 宋, 益飞/HNJ-2770-2023
FU Military Logistics Key Open Research Projects [BHJ17L018]; National
   Natural Science Foundation of China [81602408]
FX This research was funded by the Military Logistics Key Open Research
   Projects (BHJ17L018) and National Natural Science Foundation of China
   (81602408).
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NR 109
TC 13
Z9 14
U1 2
U2 18
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1424-8247
J9 PHARMACEUTICALS-BASE
JI Pharmaceuticals
PD APR
PY 2023
VL 16
IS 4
AR 541
DI 10.3390/ph16040541
PG 27
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA E6YZ7
UT WOS:000976989000001
PM 37111299
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Lv, CY
   Wang, YF
   Zhou, C
   Ma, WW
   Yang, YX
   Xiao, R
   Yu, HL
AF Lv, Chenyan
   Wang, Yifei
   Zhou, Cui
   Ma, Weiwei
   Yang, Yuexin
   Xiao, Rong
   Yu, Huanling
TI Effects of dietary palm olein on the cardiovascular risk factors in
   healthy young adults
SO FOOD & NUTRITION RESEARCH
LA English
DT Article
DE palm olein; saturated fatty acids; dietary intervention; replacement;
   lipid metabolism
ID SATURATED FATTY-ACIDS; CORONARY-HEART-DISEASE; CARDIOMETABOLIC RISK;
   PLASMA-CHOLESTEROL; SERUM-CHOLESTEROL; OXIDATIVE STRESS; SN-2 POSITION;
   OIL; SUPPLEMENTATION; TRIACYLGLYCEROLS
AB Background: Dietary saturated fatty acids are always being hotly debated. Palm olein rich in saturated fatty acids (45.98%) is often considered as being atherogenic nutritionally. There is a lack of information on effects of dietary oil by partially replacing with palm olein on human health.
   Methods: A randomized controlled trial with 88 participants has been conducted to elucidate the effect of palm olein on cardiovascular risk factors.
   Results: By comparing the soybean oil group (saturated fatty acids amounted to 23.31%) with the cocoa butter group (saturated fatty acids amounted to 93.76%), no significant difference was found (p > 0.05) in physiological parameters, serum oxidative stress levels, inflammatory factor, glucose metabolism, and lipid profiles of subjects, which are all cardiovascular risk factors. Although results showed that intervention time can influence the cardiovascular risk factors significantly (p < 0.05), there is no relationship between intervention time and dietary oil type.
   Conclusion: Therefore, partial replacement of dietary oil by palm olein may not affect cardiovascular risk factors in healthy young adults. There are differences between our research and previous researches, which may be due to the different amount of palm olien in diet. Our research will provide a solid foundation for the application of palm olein in human diets and in the food industry.
C1 [Lv, Chenyan; Wang, Yifei; Zhou, Cui; Ma, Weiwei; Xiao, Rong; Yu, Huanling] Capital Med Univ, Sch Publ Hlth, Beijing Key Lab Environm Toxicol, 10 Xitoutiao, Beijing 100069, Peoples R China.
   [Yang, Yuexin] Chinese Ctr Dis Control & Prevent, Natl Inst Nutr & Hlth, Beijing, Peoples R China.
C3 Capital Medical University; Chinese Center for Disease Control &
   Prevention
RP Xiao, R; Yu, HL (corresponding author), Capital Med Univ, Sch Publ Hlth, Beijing Key Lab Environm Toxicol, 10 Xitoutiao, Beijing 100069, Peoples R China.
EM xiaor22@ccmu.edu.cn; yuhlzjl@ccmu.edu.cn
RI Zhou, Cui/KHW-2618-2024; Wang, Yifei/IWD-7349-2023; yu,
   huan/ITT-7452-2023
OI Zhou, Cui/0000-0001-6311-9998
FU Chinese Nutrition Society and Malaysian palm bureau
FX We are grateful to the canteen of Capital Medical University for
   providing the diets. This work was supported by Mutual fund of the
   Chinese Nutrition Society and Malaysian palm bureau [Project 2].
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NR 34
TC 10
Z9 11
U1 0
U2 8
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1654-6628
EI 1654-661X
J9 FOOD NUTR RES
JI Food Nutr. Res.
PD JUL 16
PY 2018
VL 62
AR 1353
DI 10.29219/fnr.v62.1353
PG 10
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA GN0ZM
UT WOS:000438711000001
PM 30038554
OA gold, Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Elomaa, AP
   Koivumaa-Honkanen, H
   Niskanen, L
   Honkalampi, K
   Valkonen-Korhonen, M
   Herzig, KH
   Viinamäki, H
   Lehto, SM
AF Elomaa, Antti-Pekka
   Koivumaa-Honkanen, Heli
   Niskanen, Leo
   Honkalampi, Kirsi
   Valkonen-Korhonen, Minna
   Herzig, Karl-Heinz
   Viinamaki, Heimo
   Lehto, Soili M.
TI Self-reported sleep disturbance is associated with elevated levels of
   PAI-1 in individuals with a recorded history of depressive symptoms
SO PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
LA English
DT Article
DE Depression; Inflammation; PAI-1; Sleep disturbance
ID PLASMINOGEN-ACTIVATOR INHIBITOR; C-REACTIVE PROTEIN;
   ELECTROENCEPHALOGRAPHIC SLEEP; PSYCHIATRIC-DISORDERS;
   FIBRINOLYTIC-ACTIVITY; METABOLIC SYNDROME; GENE-EXPRESSION;
   OLDER-ADULTS; INFLAMMATION; BIOMARKERS
AB Background: The majority of depressed individuals report insomnia. Self-reported symptoms of insomnia, in particular, more strongly predict adverse health effects than the actual measured sleep time. The physiological alterations in individuals with insomnia are complex, as both autonomic and endocrine dysfunctions are present. Plasminogen activator inhibitor (PAI)-1 is a stress-related acute-phase reactant that has also been suggested to regulate the circadian rhythm and sleep patterns. It has been suggested to contribute to both depressive symptoms and sleep disorders, although data on the relationships between these parameters are scarce.
   Objective: This study examined the role of self-reported sleep disturbance and its association with PAI-1 among individuals with a history of depressive symptoms.
   Methods: Differences in the serum levels of PAI-1 between two groups (group 1: moderate to very severe sleep disturbance, n = 37; group 2: mild or no sleep disturbance, n = 90) were examined in a population-based sample of individuals with a recorded history of depressive symptoms.
   Results: Multivariate analysis controlling for potential confounding factors (age, sex, body mass index, depression severity) showed that each 1-unit increase in PAI-1 (mu g/mL) increased the likelihood for belonging to the group with moderate to very severe sleep disturbance by 23% (OR = 1.23, C.I. 95% = 1.04-1.45, p = 0.016). This statistical significance remained after additional adjustments for regular smoking and the use of sleep or lipid-lowering medication.
   Conclusion: Our observations may further clarify the physiological alterations related to sleep disturbance in depressive individuals. In the present study, self-reported sleep disturbance in individuals with a recorded history of depressive symptoms was associated with an elevation of PAI-1. This finding may illustrate the association of subjective sleep disturbance with sympathetic activation. Our study highlights the importance of effects of perceived sleep disturbance on individual homeostasis, and may provide potential directions for research on treatment options. (C) 2013 Elsevier Inc. All rights reserved.
C1 [Elomaa, Antti-Pekka; Koivumaa-Honkanen, Heli; Valkonen-Korhonen, Minna; Herzig, Karl-Heinz; Viinamaki, Heimo; Lehto, Soili M.] Kuopio Univ Hosp, Dept Psychiat, Kuopio 70210, Finland.
   [Elomaa, Antti-Pekka; Koivumaa-Honkanen, Heli; Niskanen, Leo; Valkonen-Korhonen, Minna; Herzig, Karl-Heinz; Viinamaki, Heimo; Lehto, Soili M.] Univ Easterrn Finland, Kuopio 70210, Finland.
   [Koivumaa-Honkanen, Heli] Univ Oulu, Inst Clin Med, Oulu, Finland.
   [Koivumaa-Honkanen, Heli] Lapland Hosp Dist, Dept Psychiat, Rovaniemi 97140, Finland.
   [Koivumaa-Honkanen, Heli] North Karelia Cent Hosp, South Savonia Hosp Dist, Dept Psychiat, Joensuu, Finland.
   [Koivumaa-Honkanen, Heli] SOSTERI, Sote, Iisalmi, Finland.
   [Niskanen, Leo] Finnish Med Agcy Fimea, Kuopio 70210, Finland.
   [Honkalampi, Kirsi] Kuopio Psychiat Ctr, Kuopio 70211, Finland.
   [Herzig, Karl-Heinz] Univ Oulu, Div Physiol, Inst Biomed, Oulu 90014, Finland.
   [Herzig, Karl-Heinz] Univ Oulu, Bioctr Oulu, Oulu 90014, Finland.
C3 University of Eastern Finland; University of Eastern Finland Hospital;
   Kuopio University Hospital; University of Oulu; University of Oulu;
   University of Oulu
RP Elomaa, AP (corresponding author), Univ Eastern Finland, Kuopio Univ Hosp, Dept Psychiat, POB 1777, FI-70211 Kuopio, Finland.
EM apelomaa@gmail.com
RI Koivumaa-Honkanen, Heli/L-1274-2015
OI Lehto, Soili/0000-0003-4324-6679
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NR 67
TC 4
Z9 4
U1 0
U2 15
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0278-5846
EI 1878-4216
J9 PROG NEURO-PSYCHOPH
JI Prog. Neuro-Psychopharmacol. Biol. Psychiatry
PD DEC 2
PY 2013
VL 47
BP 46
EP 51
DI 10.1016/j.pnpbp.2013.07.017
PG 6
WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA 248FX
UT WOS:000326682300008
PM 23911442
DA 2025-06-11
ER

PT J
AU Nagappan, A
   Shin, J
   Jung, MH
AF Nagappan, Arulkumar
   Shin, Jooyeon
   Jung, Myeong Ho
TI Role of Cannabinoid Receptor Type 1 in Insulin Resistance and Its
   Biological Implications
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE cannabinoid receptor type 1; metabolic disorders; insulin resistance;
   obesity; diabetes
ID HEPATIC CB1 RECEPTOR; DIET-INDUCED OBESITY; GAMMA ERR-GAMMA;
   ENDOCANNABINOID SYSTEM; OXIDATIVE STRESS; SIGNAL-TRANSDUCTION;
   ADIPOSE-TISSUE; CARDIOMETABOLIC RISK; WEIGHT-LOSS; EXPRESSION
AB Endogenous cannabinoids (ECs) are lipid-signaling molecules that specifically bind to cannabinoid receptor types 1 and 2 (CB1R and CB2R) and are highly expressed in central and many peripheral tissues under pathological conditions. Activation of hepatic CB1R is associated with obesity, insulin resistance, and impaired metabolic function, owing to increased energy intake and storage, impaired glucose and lipid metabolism, and enhanced oxidative stress and inflammatory responses. Additionally, blocking peripheral CB1R improves insulin sensitivity and glucose metabolism and also reduces hepatic steatosis and body weight in obese mice. Thus, targeting EC receptors, especially CB1R, may provide a potential therapeutic strategy against obesity and insulin resistance. There are many CB1R antagonists, including inverse agonists and natural compounds that target CB1R and can reduce body weight, adiposity, and hepatic steatosis, and those that improve insulin sensitivity and reverse leptin resistance. Recently, the use of CB1R antagonists was suspended due to adverse central effects, and this caused a major setback in the development of CB1R antagonists. Recent studies, however, have focused on development of antagonists lacking adverse effects. In this review, we detail the important role of CB1R in hepatic insulin resistance and the possible underlying mechanisms, and the therapeutic potential of CB1R targeting is also discussed.
C1 [Nagappan, Arulkumar; Jung, Myeong Ho] Pusan Natl Univ, Sch Korean Med, Hlth Aging Korean Med Res Ctr, Yangsan 50612, South Korea.
   [Nagappan, Arulkumar; Shin, Jooyeon; Jung, Myeong Ho] Pusan Natl Univ, Sch Korean Med, Div Longev & Biofunct Med, Yangsan 50612, South Korea.
C3 Pusan National University; Pusan National University
RP Jung, MH (corresponding author), Pusan Natl Univ, Sch Korean Med, Hlth Aging Korean Med Res Ctr, Yangsan 50612, South Korea.; Jung, MH (corresponding author), Pusan Natl Univ, Sch Korean Med, Div Longev & Biofunct Med, Yangsan 50612, South Korea.
EM arulbiotechtnau@gmail.com; jooyeonshine@naver.com; jung0603@pusan.ac.kr
OI NAGAPPAN, ARULKUMAR/0000-0003-3169-9064
FU National Research Foundation of Korea (NRF) - Korean government (MSIP)
   [2014R1A5A2009936]
FX This study was supported by the National Research Foundation of Korea
   (NRF) grant funded by the Korean government (MSIP) (No.
   2014R1A5A2009936).
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NR 109
TC 42
Z9 42
U1 2
U2 10
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD MAY 1
PY 2019
VL 20
IS 9
AR 2109
DI 10.3390/ijms20092109
PG 17
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA IA7RK
UT WOS:000469753500056
PM 31035653
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Giralt, A
   Villarroya, F
AF Giralt, Albert
   Villarroya, Francesc
TI SIRT3, a pivotal actor in mitochondrial functions: metabolism, cell
   death and aging
SO BIOCHEMICAL JOURNAL
LA English
DT Review
DE aging; mitochondrion; oxidative stress; SIRT3; sirtuin; thermogenesis
ID FATTY-ACID OXIDATION; BROWN ADIPOSE-TISSUE; CALORIE RESTRICTION;
   CYCLOPHILIN-D; SIRT3-MEDIATED DEACETYLATION; FREE ACETATE; SIRTUINS;
   PROTEIN; ACTIVATION; ACETYLATION
AB SIRT3 is a member of the sirtuin family of protein deacetylases that is preferentially localized to mitochondria. Prominent among the proteins targeted by SIRT3 are enzymes involved in energy metabolism processes, including the respiratory chain, tricarboxylic acid cycle, fatty acid beta-oxidation and ketogenesis. Through these actions, SIRT3 controls the flow of mitochondrial oxidative pathways and, consequently, the rate of production of reactive oxygen species. In addition, SIRT3-mediated deacetylation activates enzymes responsible for quenching reactive oxygen species, and thereby exerts a profound protective action against oxidative stress-dependent pathologies, such as cardiac hypertrophy and neural degeneration. SIRT3 also plays a role in multiple additional metabolic processes, from acetate metabolism to brown adipose tissue thermogenesis, often by controlling mitochondrial pathways through the deacetylation of target enzymes. In general, SIRT3 activity and subsequent control of enzymes involved in energy metabolism is consistent with an overall role of protecting against age-related diseases. In fact, experimental and genetic evidence has linked SIRT3 activity with increased lifespan. In the coming years, the identification of drugs and nutrients capable of increasing SIRT3 expression or modulating SIRT3 activity can be expected to provide promising strategies for ameliorating the metabolic syndrome and other oxidative stress-related diseases that appear preferentially with aging, such as cancer, cardiac dysfunction and neural degeneration. SIRT3 is a member of the sirtuin family of protein deacetylases that is preferentially localized to mitochondria. Prominent among the proteins targeted by SIRT3 are enzymes involved in energy metabolism processes, including the respiratory chain, tricarboxylic acid cycle, fatty acid beta-oxidation and ketogenesis. Through these actions, SIRT3 controls the flow of mitochondrial oxidative pathways and, consequently, the rate of production of reactive oxygen species. In addition, SIRT3-mediated deacetylation activates enzymes responsible for quenching reactive oxygen species, and thereby exerts a profound protective action against oxidative stress-dependent pathologies, such as cardiac hypertrophy and neural degeneration. SIRT3 also plays a role in multiple additional metabolic processes, from acetate metabolism to brown adipose tissue thermogenesis, often by controlling mitochondrial pathways through the deacetylation of target enzymes. In general, SIRT3 activity and subsequent control of enzymes involved in energy metabolism is consistent with an overall role of protecting against age-related diseases. In fact, experimental and genetic evidence has linked SIRT3 activity with increased lifespan. In the coming years, the identification of drugs and nutrients capable of increasing SIRT3 expression or modulating SIRT3 activity can be expected to provide promising strategies for ameliorating the metabolic syndrome and other oxidative stress-related diseases that appear preferentially with aging, such as cancer, cardiac dysfunction and neural degeneration.
C1 [Villarroya, Francesc] Univ Barcelona, Dept Bioquim & Biol Mol, Fac Biol, E-08028 Barcelona, Spain.
   Univ Barcelona, Inst Biomed, E-08028 Barcelona, Spain.
   Inst Salud Carlos III, CIBER Fisitopatol Obesidad & Nutr, Barcelona, Spain.
C3 University of Barcelona; University of Barcelona; Instituto de Salud
   Carlos III
RP Villarroya, F (corresponding author), Univ Barcelona, Dept Bioquim & Biol Mol, Fac Biol, Avda Diagonal 643, E-08028 Barcelona, Spain.
EM fvillarroya@ub.edu
RI Villarroya, Francesc/K-4357-2014
OI Villarroya, Francesc/0000-0003-1266-9142; Giralt,
   Albert/0000-0003-4498-063X
FU Spanish Ministerio de Ciencia e Innovacion (MICINN) [SAF2008-01896,
   SAF2011-23636]; Generalitat de Catalunya [2009SGR284]; European
   Commission [277713]
FX Our work is funded by the Spanish Ministerio de Ciencia e Innovacion
   (MICINN) [grant numbers SAF2008-01896 and SAF2011-23636], Generalitat de
   Catalunya [grant number 2009SGR284] and the European Commission
   Framework Program "HEALTH" [contract number 277713].
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NR 87
TC 197
Z9 231
U1 6
U2 77
PU PORTLAND PRESS LTD
PI LONDON
PA CHARLES DARWIN HOUSE, 12 ROGER STREET, LONDON WC1N 2JU, ENGLAND
SN 0264-6021
EI 1470-8728
J9 BIOCHEM J
JI Biochem. J.
PD MAY 15
PY 2012
VL 444
BP 1
EP 10
DI 10.1042/BJ20120030
PN 1
PG 10
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 948GH
UT WOS:000304491100001
PM 22533670
DA 2025-06-11
ER

PT J
AU Hansel, B
   Girerd, X
   Bonnefont-Rousselot, D
   Bittar, R
   Chantepie, S
   Orsoni, A
   Bruckert, E
   Chapman, MJ
   Kontush, A
AF Hansel, Boris
   Girerd, Xavier
   Bonnefont-Rousselot, Dominique
   Bittar, Randa
   Chantepie, Sandrine
   Orsoni, Alexina
   Bruckert, Eric
   Chapman, M. John
   Kontush, Anatol
TI Blood Pressure-Lowering Response to Amlodipine as a Determinant of the
   Antioxidative Activity of Small, Dense HDL3
SO AMERICAN JOURNAL OF CARDIOVASCULAR DRUGS
LA English
DT Article
ID ELEVATED OXIDATIVE STRESS; CALCIUM-CHANNEL BLOCKER; APOLIPOPROTEIN-A-I;
   ESSENTIAL-HYPERTENSION; LIPID-PEROXIDATION; INSULIN-RESISTANCE;
   METABOLIC SYNDROME; CLINICAL EVENTS; LIPOPROTEIN; CHOLESTEROL
AB Background and Objective: High-density lipoproteins (HDLs) exert multiple antiatherogenic activities including protection of low-density lipoproteins (LDLs) from oxidative stress. Beneficial effects of calcium channel blockers on cardiovascular disease may in part be related to the reduction of oxidative stress, potentially enhancing the antioxidative activity (AOX) of HDLs. This study aimed to assess the effect of 1 month's treatment with amlodipine on HDL AOX in hypertensive subjects.
   Methods: This was a prospective trial of amlodipine 10 mg/day administered for 1 month in primary-care patients with hypertension (n = 28), 46% of whom were obese and 57% of whom displayed the metabolic syndrome. The main outcome measure was HDL AOX, assessed as the capacity of small, dense HDL3c particles to attenuate LDL oxidation induced in vitro by an azo initiator (AAPH).
   Results: Mean (+/- SD) systolic (SBP) and diastolic (DBP) BP were reduced by amlodipine by 22.1 mmHg (+/- 13.2) and 10.4 mmHg (+/- 7.5), respectively (p<0.001). Body mass index, waist circumference, and plasma levels of triglycerides, cholesterol, and fasting blood glucose did not change significantly. Amlodipine treatment did not modify HDL3c AOX in the whole study population; changes in AOX were, however, positively correlated with SBP (r = 0.37, p = 0.05 for maximal diene concentration; r = 0.34, p = 0.08 for LDL oxidation rate). When the population was divided into two subgroups according to the BP response to amlodipine (change in SBP below or above the median), HDL3c AOX was significantly improved in hyper-responders (BP-lowering response >22/10 mmHg) as compared with hypo-responders (BP-lowering response <22/10 mmHg: mean [SD] change in the LDL oxidation rate in the presence of HDL3c, -6.8% [+/- 11.2] vs +1.9% [+/- 5.2], respectively, p = 0.04; maximal diene concentration, -8.6% [+/- 13.0] vs +1.9% [+/- 8.2], respectively, p<0.05). By contrast, neither plasma concentrations of oxidized LDL, a marker of systemic oxidative stress, nor the chemical composition of HDL3c were modified between the subgroups.
   Conclusions: In hypertensive patients, amlodipine treatment enhanced HDL AOX in subjects who had a BP reduction that exceeded the median response. This effect appears to be secondary to the hypotensive effect, rather than to the direct antioxidant properties, of the drug.
C1 [Hansel, Boris; Girerd, Xavier; Bruckert, Eric] Hop Pitie, AP HP, Serv Endocrinol Metab, F-75651 Paris 13, France.
   [Hansel, Boris; Girerd, Xavier; Chantepie, Sandrine; Orsoni, Alexina; Bruckert, Eric; Chapman, M. John; Kontush, Anatol] INSERM, UMR 939, Dyslipidemia Inflammat & Atherosclerosis Res Unit, Paris, France.
   [Hansel, Boris; Girerd, Xavier; Chantepie, Sandrine; Orsoni, Alexina; Bruckert, Eric; Chapman, M. John; Kontush, Anatol] Univ Paris 06, Hop Pitie, Paris, France.
   [Bonnefont-Rousselot, Dominique; Bittar, Randa] Grp Hosp Pitie Salpetriere, AP HP, Serv Biochim Metab, F-75634 Paris, France.
   [Bonnefont-Rousselot, Dominique] Univ Paris 05, Fac Sci Pharmaceut & Biol, Dept Biochim, EA 4466, Paris, France.
C3 Sorbonne Universite; Assistance Publique Hopitaux Paris (APHP); Hopital
   Universitaire Pitie-Salpetriere - APHP; Institut National de la Sante et
   de la Recherche Medicale (Inserm); Sorbonne Universite; Assistance
   Publique Hopitaux Paris (APHP); Hopital Universitaire Pitie-Salpetriere
   - APHP; Assistance Publique Hopitaux Paris (APHP); Hopital Universitaire
   Pitie-Salpetriere - APHP; Sorbonne Universite; Universite Paris Cite
RP Hansel, B (corresponding author), Hop Pitie, AP HP, Serv Endocrinol Metab, Pavillon Benjamin Delessert,83 Blvd Hop, F-75651 Paris 13, France.
EM boris.hansel@psl.aphp.fr
RI chapman, john/Y-2742-2019; Rousselot, Bonnefont/U-7434-2019; Kontush,
   Anatol/J-2198-2016; ORSONI, Alexina/C-6740-2009
OI ORSONI, Alexina/0000-0003-4250-6280; Kontush,
   Anatol/0000-0002-9008-7335; CHANTEPIE-LABORDE,
   Sandrine/0000-0003-1652-432X; Bonnefont-Rousselot,
   Dominique/0000-0003-4689-9202
FU French Society of Hypertension; New French Atheroslerosis Society;
   Pfizer; Assistance Publique-Hopitaux de Paris/INSERM (France)
FX This study was supported by research grants from the French Society of
   Hypertension, the New French Atheroslerosis Society, and Pfizer. MJ
   Chapman and A Kontush gratefully acknowledge the award of a Contrat
   d'Interface from Assistance Publique-Hopitaux de Paris/INSERM (France).
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NR 39
TC 5
Z9 6
U1 0
U2 5
PU ADIS INT LTD
PI AUCKLAND
PA 41 CENTORIAN DR, PRIVATE BAG 65901, MAIRANGI BAY, AUCKLAND 1311, NEW
   ZEALAND
SN 1175-3277
J9 AM J CARDIOVASC DRUG
JI Am. J. Cardiovasc. Drugs
PY 2011
VL 11
IS 5
BP 317
EP 325
DI 10.2165/11592280-000000000-00000
PG 9
WC Cardiac & Cardiovascular Systems; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Pharmacology & Pharmacy
GA 833DC
UT WOS:000295861000004
PM 21699274
DA 2025-06-11
ER

PT J
AU Hegazy, MA
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AF Hegazy, Mona A.
   Ahmed, Safaa M.
   Sultan, Shaimaa M.
   Afifi, Osama F.
   Mohamed, Manal A.
   Azab, Alshimaa E.
   Hassanen, Mohamed A.
   Zaben, Rakan K.
TI Metabolic dysfunction-associated steatotic liver disease and omega-6
   polyunsaturated fatty acids: Friends or foes
SO WORLD JOURNAL OF HEPATOLOGY
LA English
DT Article
DE Metabolic dysfunction-associated steatotic liver disease; Omega-6
   polyunsaturated fatty acids; Conjugated linoleic acid; Arachidonic acid;
   Lipid metabolism; Oxidative stress; Steatohepatitis; Eicosanoids
ID GAMMA-LINOLENIC ACID; CARDIOVASCULAR-DISEASE; INSULIN-RESISTANCE;
   ARACHIDONIC-ACID; LIPIDS; RATIO; DIET; OIL
AB BACKGROUND Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver disease worldwide. Its prevalence is closely linked to the dramatic rise in obesity and non-communicable diseases. MASLD exhibits a progressive trajectory that may culminate in development of hepatic cirrhosis, thereby predisposing affected individuals to an elevated likelihood of hepatocarcinogenesis. Diet, especially dietary fatty acids, serves as a key link between nutrient intake and MASLD pathogenesis. AIM To explore the impact of various omega-6 fatty acid subtypes on the pathogenesis and therapeutic strategies of MASLD. METHODS A systematic literature search was conducted across Web of Science, PubMed, Cochrane Central, Scopus, and Embase databases from inception through June 2024 to identify all original studies linking different subtypes of omega-6 polyunsaturated fatty acids to the pathogenesis and management of MASLD. The search strategy explored the linkage between omega-6 polyunsaturated fatty acids and their subtypes, including linoleic acid (LA), gamma-linolenic acid (GLA), arachidonic acid, conjugated LA, and docosapentaenoic acid, in relation to MASLD and cardiometabolic risk. RESULTS By employing the specified search strategy, a total of 83 articles were identified as potentially eligible. During the title, abstract, and full-text screening phases, 27 duplicate records were removed, leaving 56 records for relevance screening. Of these, 43 records were excluded for reasons such as irrelevance and language restrictions (limited to English), resulting in 13 full-text articles being included for detailed assessment (10 human studies,1 animal study, and 2 review articles). Although certain subtypes, as GLA, dihomo-GLA, omega-6-derived oxylipins, and most arachidonic acid-derived eicosanoids, exhibit pro-inflammatory effects, our findings suggest that other subtypes such as LA, cis-9, trans-11 conjugated LA, and docosapentaenoic acid have beneficial effects on fatty liver, cardiometabolic risk factors, and inflammation, even at high intake levels. CONCLUSION The varying health effects of omega-6 fatty acids, ranging from anti-inflammatory to pro-inflammatory impacts on the liver, leave the question of their recommendation for MASLD patients unresolved. This underscores the importance of careful selection when considering omega-6 supplementation.
C1 [Hegazy, Mona A.] Cairo Univ, Kasr Aliny Hosp, Fac Med, Dept Internal Med, Kasr Alainy St, Cairo 12556, Egypt.
   [Ahmed, Safaa M.] Mounira Gen Hosp, Dept Neonatol, Cairo, Egypt.
   [Sultan, Shaimaa M.] Shubra Elkhema Med Adm, Dept Maternal & Pediat Hlth, Qalyubia, Egypt.
   [Afifi, Osama F.] Ashmoun Hosp, Dept Neonatol, Menoufia 32811, Egypt.
   [Mohamed, Manal A.] Elnasr Hosp, Dept Internal Med, Helwan 11731, Egypt.
   [Azab, Alshimaa E.] Al Helal Hlth Insurance Hosp, Qism Shebin, Egypt.
   [Hassanen, Mohamed A.; Zaben, Rakan K.] Egyptian Fellowship, Dept Clin Nutr, Cairo 11516, Egypt.
C3 Egyptian Knowledge Bank (EKB); Cairo University
RP Hegazy, MA (corresponding author), Cairo Univ, Kasr Aliny Hosp, Fac Med, Dept Internal Med, Kasr Alainy St, Cairo 12556, Egypt.
EM monahegazy@cu.edu.eg
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NR 54
TC 0
Z9 0
U1 1
U2 1
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 7041 Koll Center Parkway, Suite 160, PLEASANTON, CA, UNITED STATES
SN 1948-5182
J9 WORLD J HEPATOL
JI World J. Hepatol.
PD MAR 27
PY 2025
VL 17
IS 3
AR 102286
DI 10.4254/wjh.v17.i3.102286
PG 13
WC Gastroenterology & Hepatology
WE Emerging Sources Citation Index (ESCI)
SC Gastroenterology & Hepatology
GA 0WA1R
UT WOS:001457355900006
PM 40177210
DA 2025-06-11
ER

PT J
AU Krentz, AJ
   Patel, MB
   Bailey, CJ
AF Krentz, Andrew J.
   Patel, Mayank B.
   Bailey, Clifford J.
TI New Drugs for Type 2 Diabetes Mellitus What is their Place in Therapy?
SO DRUGS
LA English
DT Review
ID GLUCAGON-LIKE PEPTIDE-1; DIPEPTIDYL PEPTIDASE-4 INHIBITOR;
   METFORMIN-TREATED PATIENTS; IMPROVES GLYCEMIC CONTROL; CANNABINOID-1
   RECEPTOR BLOCKER; CARDIOMETABOLIC RISK-FACTORS; ORAL ANTIDIABETIC
   AGENTS; BLOOD-GLUCOSE CONTROL; BETA-CELL FUNCTION; FACTOR-KAPPA-B
AB Oral therapy for type 2 diabetes mellitus, when used appropriately, can safely assist patients to achieve glycaemic targets in the short to medium term. However, the progressive nature of type 2 diabetes usually requires a combination of two or more oral agents in the longer term, often as a prelude to insulin therapy. Issues of safety and tolerability, notably weight gain, often limit the optimal application of anti-diabetic drugs such as sulforylureas and thiazolidinediones. Moreover, the impact of different drugs, even within a single class, on the risk of long-term vascular complications has come under scrutiny. For example, recent publication of evidence suggesting potential detrimental effects of rosiglitazone on myocardial events generated a heated debate and led to a reduction in use of this drug. In contrast, current evidence supports the view that pioglitazone has vasculoprotective properties. Both drugs are contraindicated in patients who are at risk of heart failure. An additional recently identified safety concern is an increased risk of fractures, especially in postmenopausal women.
   Several new drugs with glucose-lowering efficacy that may offer certain advantages have recently become available. These include (i) injectable glucagonlike peptide-1 (GLP-1) receptor agonists and oral dipeptidyl peptidase-4 (DPP-4) inhibitors; (ii) the amylin analogue pramlintide; and (iii) selective cannabinoid receptor-1 (CB1) antagonists. GLP-1 receptor agonists, such as exenatide, stimulate nutrient-induced insulin secretion and reduce inappropriate glucagon secretion while delaying gastric emptying and reducing appetite. These agents offer a low risk of hypoglycaemia combined with sustained weight loss. The DPP-4 inhibitors sitagliptin and vildagliptin are generally weight neutral, with less marked gastrointestinal adverse effects than the GLP-1 receptor agonists. Potential benefits of GLP-1 receptor stimulation on P cell neogenesis are under investigation. Pancreatitis has been reported in exenatide-treated patients. Pramlintide, an injected peptide used in combination with insulin, can reduce insulin dose and bodyweight. The CB1 receptor antagonist rimonabant promotes weight loss and has favourable effects on aspects of the metabolic syndrome, including the hyperglycaemia of type 2 diabetes. However, in 2007 the US FDA declined approval of rimonabant, requiring more data on adverse effects, notably depression. The future of dual peroxisome proliferator-activated receptor-alpha/gamma agonists, or glitazars, is presently uncertain following concerns about their safety.
   In conclusion, several new classes of drugs have recently become available in some countries that offer new options for treating type 2 diabetes. Beneficial or neutral effects on bodyweight are an attractive feature of the new drugs. However, the higher cost of these agents, coupled with an absence of long-term safety and clinical outcome data, need to be taken into consideration by clinicians and healthcare organizations.
C1 [Krentz, Andrew J.; Patel, Mayank B.] Southampton Univ Hosp, Dept Endocrinol & Diabet, Southampton, Hants, England.
   [Krentz, Andrew J.; Patel, Mayank B.] Univ Southampton, Southampton, Hants, England.
   [Bailey, Clifford J.] Aston Univ, Sch Life & Hlth Sci, Birmingham B4 7ET, W Midlands, England.
C3 University of Southampton; University of Southampton; Aston University
RP Krentz, AJ (corresponding author), Southampton Gen Hosp, Mailpoint 48, Southampton SO16 6YD, Hants, England.
EM a.j.krentz@soton.ac.uk
RI Krentz, Andrew/AAD-2493-2019
OI Bailey, Clifford J/0000-0002-6998-6811
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NR 215
TC 95
Z9 102
U1 0
U2 34
PU ADIS INT LTD
PI NORTHCOTE
PA 5 THE WAREHOUSE WAY, NORTHCOTE 0627, AUCKLAND, NEW ZEALAND
SN 0012-6667
EI 1179-1950
J9 DRUGS
JI Drugs
PY 2008
VL 68
IS 15
BP 2131
EP 2162
DI 10.2165/00003495-200868150-00005
PG 32
WC Pharmacology & Pharmacy; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Toxicology
GA 373IK
UT WOS:000260965100005
PM 18840004
DA 2025-06-11
ER

PT J
AU Cramer, H
   Hohmann, C
   Lauche, R
   Choi, KE
   Schneider, N
   Steckhan, N
   Rathjens, F
   Anheyer, D
   Paul, A
   von Scheidt, C
   Ostermann, T
   Schneider, E
   Koppold-Liebscher, DA
   Kessler, CS
   Dobos, G
   Michalsen, A
   Jeitler, M
AF Cramer, Holger
   Hohmann, Christoph
   Lauche, Romy
   Choi, Kyung-Eun (Anna)
   Schneider, Nadia
   Steckhan, Nico
   Rathjens, Florian
   Anheyer, Dennis
   Paul, Anna
   von Scheidt, Christel
   Ostermann, Thomas
   Schneider, Elisabeth
   Koppold-Liebscher, Daniela A.
   Kessler, Christian S.
   Dobos, Gustav
   Michalsen, Andreas
   Jeitler, Michael
TI Effects of Fasting and Lifestyle Modification in Patients with Metabolic
   Syndrome: A Randomized Controlled Trial
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Article
DE fasting; metabolic syndrome; modified DASH diet; Mediterranean diet;
   lifestyle; relaxation; MICOM (mind-body medicine in integrative and
   complementary medicine)
ID CORONARY-ARTERY-DISEASE; BLOOD-PRESSURE; RISK-FACTORS; SECONDARY
   PREVENTION; STRESS REDUCTION; DIET; COUNTRIES; TIME; WEIGHT
AB Background: Lifestyle interventions, such as fasting, diet, and exercise, are increasingly used as a treatment option for patients with metabolic syndrome (MS). This study assesses the efficacy and safety of fasting followed by lifestyle modification in patients with MS compared to lifestyle modification only. Methods: Single-blind, multicenter, parallel, randomized controlled trial in two German tertiary referral hospitals in metropolitan areas. Interventions: (a) 5-day fasting followed by 10 weeks of lifestyle modification (modified DASH diet, exercise, mindfulness; n = 73); (b) 10 weeks of lifestyle modification only (n = 72). Main outcomes and measures: Co-primary outcomes were ambulatory systolic blood pressure and the homeostasis model assessment (HOMA) index at week 12. Further outcomes included anthropometric, laboratory parameters, and the PROCAM score at weeks 1, 12, and 24. Results: A total of 145 patients with metabolic syndrome (62.8% women; 59.7 +/- 9.3 years) were included. No significant group differences occurred for the co-primary outcomes at week 12. However, compared to lifestyle modification only, fasting significantly reduced HOMA index (Delta = -0.8; 95% confidence interval [CI] = -1.7, -0.1), diastolic blood pressure (Delta = -4.8; 95% CI = -5.5, -4.1), BMI (Delta = -1.7; 95% CI = -2.0, -1.4), weight (Delta = -1.7; 95% CI = -2.0, -1.4), waist circumference (Delta = -2.6; 95% CI = -5.0, -0.2), glucose (Delta = -10.3; 95% CI = -19.0, -1.6), insulin (Delta = -2.9; 95% CI = -5.3, -0.4), HbA1c (Delta = -0.2; 95% CI = -0.4, -0.05;), triglycerides (Delta = -48.9; 95% CI = -81.0, -16.9), IL-6 (Delta = -1.2; 95% CI = -2.5, -0.005), and the 10-year risk of acute coronary events (Delta = -4.9; 95% CI = -9.5, -0.4) after week 1. Fasting increased uric acid levels (Delta = 1.0; 95% CI = 0.1, 1.9) and slightly reduced eGRF (Delta = -11.9; 95% CI = -21.8, -2.0). Group differences at week 24 were found for weight (Delta = -2, 7; 95% CI = -4.8, -0.5), BMI (Delta = -1.0; 95% CI = -1.8, -0.3), glucose (Delta = -7.7; 95% CI = -13.5, -1.8), HDL (Delta = 5.1; 95% CI = 1.5, 8.8), and CRP (Delta = 0.2; 95% CI = 0.03, 0.4). No serious adverse events occurred. Conclusions: A beneficial effect at week 24 was found on weight; fasting also induced various positive short-term effects in patients with MS. Fasting can thus be considered a treatment for initializing lifestyle modification for this patient group; however, it remains to be investigated whether and how the multilayered effects of fasting can be maintained in the medium and longer term.
C1 [Cramer, Holger; Schneider, Nadia; Rathjens, Florian; Anheyer, Dennis; Paul, Anna; Dobos, Gustav] Univ Duisburg Essen, Dept Internal & Integrat Med, Evangel Kliniken Essen Mitte, D-45276 Essen, Germany.
   [Cramer, Holger] Univ Hosp Tuebingen, Inst Gen Practice & Interprofess Care, D-72076 Tubingen, Germany.
   [Cramer, Holger] Bosch Hlth Campus, D-70376 Stuttgart, Germany.
   [Cramer, Holger; Lauche, Romy; Anheyer, Dennis] Southern Cross Univ, Natl Ctr Naturopath Med, Lismore, NSW 2480, Australia.
   [Hohmann, Christoph; Steckhan, Nico; Schneider, Elisabeth; Koppold-Liebscher, Daniela A.; Kessler, Christian S.; Michalsen, Andreas; Jeitler, Michael] Charite Univ Med Berlin, Inst Social Med Epidemiol & Hlth Econ, D-10117 Berlin, Germany.
   [Hohmann, Christoph; Steckhan, Nico; Schneider, Elisabeth; Koppold-Liebscher, Daniela A.; Kessler, Christian S.; Michalsen, Andreas; Jeitler, Michael] Free Univ Berlin, D-10117 Berlin, Germany.
   [Hohmann, Christoph; Steckhan, Nico; Schneider, Elisabeth; Koppold-Liebscher, Daniela A.; Kessler, Christian S.; Michalsen, Andreas; Jeitler, Michael] Humboldt Univ, D-10117 Berlin, Germany.
   [Choi, Kyung-Eun (Anna); Kessler, Christian S.] Brandenburg Med Sch Theodor Fontane, Ctr Hlth Serv Res, D-16816 Neuruppin, Germany.
   [Steckhan, Nico] Univ Potsdam, Digital Hlth Ctr, Hasso Plattner Inst, D-14469 Potsdam, Germany.
   [von Scheidt, Christel; Koppold-Liebscher, Daniela A.; Michalsen, Andreas; Jeitler, Michael] Immanuel Hosp Berlin, Dept Internal & Integrat Med, D-14109 Berlin, Germany.
   [Ostermann, Thomas] Witten Herdecke Univ, Dept Psychol & Psychotherapy, D-58455 Witten, Germany.
C3 University of Duisburg Essen; Eberhard Karls University of Tubingen;
   Eberhard Karls University Hospital; Southern Cross University; Berlin
   Institute of Health; Free University of Berlin; Humboldt University of
   Berlin; Charite Universitatsmedizin Berlin; Free University of Berlin;
   Humboldt University of Berlin; University of Potsdam
RP Jeitler, M (corresponding author), Charite Univ Med Berlin, Inst Social Med Epidemiol & Hlth Econ, D-10117 Berlin, Germany.; Jeitler, M (corresponding author), Free Univ Berlin, D-10117 Berlin, Germany.; Jeitler, M (corresponding author), Humboldt Univ, D-10117 Berlin, Germany.; Jeitler, M (corresponding author), Immanuel Hosp Berlin, Dept Internal & Integrat Med, D-14109 Berlin, Germany.
EM michael.jeitler@charite.de
RI Choi, Kyung-Eun/HCH-2157-2022; Ostermann, Thomas/LSK-7444-2024; Cramer,
   Holger/HPG-1828-2023; Lauche, Romy/AAQ-7175-2021; Kessler,
   Christian/KMX-3377-2024; Koppold, Daniela/HRC-4226-2023
OI Steckhan, Nico/0000-0003-0245-2046; Choi, Kyung-Eun
   (Anna)/0000-0001-5533-7450; Kessler, Christian/0000-0001-7794-8375;
   Lauche, Romy/0000-0002-4171-7935; Ostermann, Thomas/0000-0003-2695-0701;
   Koppold, Daniela/0000-0003-3367-3327; Jeitler,
   Michael/0000-0003-3277-9090; Cramer, Holger/0000-0002-3640-8046;
   Anheyer, Dennis/0000-0001-9310-8077
FU Corona-Foundation, Essen, Germany [S199/10056/2012]; Open Access
   Publication Fund of Charite-Universitatsmedizin Berlin; German Research
   Foundation (DFG)
FX This work was supported by Corona-Foundation, Essen, Germany (funding
   number: S199/10056/2012). The funder had no role in the design and
   conduct of the study; collection, management, analysis, and
   interpretation of the data; preparation, review, or approval of the
   manuscript; or decision to submit the manuscript for publication. We
   acknowledge financial support from the Open Access Publication Fund of
   Charite-Universitatsmedizin Berlin and the German Research Foundation
   (DFG).
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   WHO, 2011, WORLD REPORT ON DISABILITY, P1
   Wilkinson MJ, 2020, CELL METAB, V31, P92, DOI 10.1016/j.cmet.2019.11.004
   Ziv A, 2013, J HUM HYPERTENS, V27, P594, DOI 10.1038/jhh.2013.29
NR 50
TC 2
Z9 2
U1 0
U2 2
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD AUG
PY 2022
VL 11
IS 16
AR 4751
DI 10.3390/jcm11164751
PG 15
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 4B4WM
UT WOS:000845779700001
PM 36012990
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Immanuel, S
   Kaki, A
   Jetty, RR
   Vupputuri, SM
   Ramireddy, K
   Saravanan, RA
AF Immanuel, Sylviah
   Kaki, Aruna
   Jetty, Ramya Rachel
   Vupputuri, Sudha Manaswini
   Ramireddy, K., V
   Saravanan, R. Arul
TI Uric Acid as a Biomarker for Mood Disorders: A Comparative Study of
   Blood Uric Acid Levels Correlating With the Symptom Severity and
   Treatment Response
SO CUREUS JOURNAL OF MEDICAL SCIENCE
LA English
DT Article
DE treatment response; symptom severity; mania; mdd; bpad; mood disorders;
   uric acid levels
ID BIPOLAR DISORDER; DIFFERENT PHASES; PURINERGIC SYSTEM; RATING-SCALE;
   MANIA; ILLNESS; METAANALYSIS
AB Background Bipolar affective disorder (BPAD) and major depressive disorder (MDD) are two mood disorders whose pathophysiology may involve the purinergic system. Elevated uric acid levels, associated with this system, can impact various behaviors in individuals affected by these conditions. In addition to genetic predisposition, blood uric acid levels can be impacted by various factors, including metabolic syndrome, the consumption of psychoactive medications, and other underlying kidney conditions such as gout. Objective The study aims to investigate the relationship between blood uric acid levels and mental health conditions, specifically BPAD subtypes (manic and depressive) and MDD. The study also examines changes in blood uric acid levels following treatment and evaluates the effectiveness of different treatment approaches in reducing uric acid levels. Methodology To be eligible to participate, individuals must have a confirmed diagnosis of BPAD (manic or depressive type) or MDD, according to the International Classification of Diseases (ICD-10). Blood uric acid levels were measured at both baseline and follow-up assessments. Symptoms were assessed weekly using standardized rating scales (Young Mania Rating Scale (YMRS) and Hamilton Rating Scale for Depression (HAM-D)) until treatment response was achieved, which was defined as a 50% reduction in initial scores on both scales. We used ANOVA to examine the differences among the three patient groups and paired sample t-tests to examine the changes in means before and after treatment conditions. Results A significant positive correlation was found between the severity of illness and serum uric acid levels across all three patient groups: those with BPAD-mania, BPAD-depression, and MDD. Notably, patients with BPADmania patients had significantly higher serum uric acid levels (5.2 +/- 0.9 mg/dL) compared to those with BPADdepression (4.8 +/- 1.0 mg/dL) and MDD (4.0 +/- 1.1 mg/dL). After treatment, all patient groups exhibited a decrease in serum uric acid levels. The reduction in serum uric acid levels was pronounced in all patient groups, with decreases of 3.1 +/- 0.8 mg/dL in patients with BPAD-mania, 3.1 +/- 0.9 mg/dL in those with BPADdepression, and 3.5 +/- 1.1 mg/dL in those with MDD. The study showed that the reduction in serum uric acid levels was significantly correlated with the severity of illness in patients with BPAD-mania, but not in those with BPAD-depression or MDD. Furthermore, the study found that treatment with lithium carbonate, sodium valproate, or carbamazepine was equally effective in reducing serum uric acid levels, regardless of the mood stabilizer used. Conclusion The study supports that dysfunction in the purine system might play a significant role in the development and progression of BPAD, suggesting that this phenomenon is not solely due to chronicity or medication exposure. This study also introduces a fresh perspective on the underlying biological processes that contribute to the development of BPAD and also sheds light on new treatment regimens targeting uric acid reduction in treating patients with bipolar disorder.
C1 [Immanuel, Sylviah; Kaki, Aruna; Jetty, Ramya Rachel; Saravanan, R. Arul] SRM Med Coll Hosp & Res Ctr, Psychiat, Chennai, India.
   [Vupputuri, Sudha Manaswini] Dist Hosp, Psychiat, Parvathipuram, India.
   [Ramireddy, K., V] Andhra Med Coll, Psychiat, Visakhapatnam, India.
C3 SRM Institute of Science & Technology Chennai; Andhra Medical College
RP Kaki, A (corresponding author), SRM Med Coll Hosp & Res Ctr, Psychiat, Chennai, India.
EM kakia@srmist.edu.in
RI Ramachandran, Arul Saravanan/ABD-8775-2020
CR Albert U, 2015, J AFFECT DISORDERS, V173, P170, DOI 10.1016/j.jad.2014.11.005
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NR 30
TC 1
Z9 1
U1 4
U2 4
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
EI 2168-8184
J9 CUREUS J MED SCIENCE
JI Cureus J Med Sci
PD AUG 13
PY 2024
VL 16
IS 8
AR e66784
DI 10.7759/cureus.66784
PG 17
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA D3Y1D
UT WOS:001295564500003
PM 39268307
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Ghoneum, M
   Abdulmalek, S
   Pan, DY
AF Ghoneum, Mamdooh
   Abdulmalek, Shaymaa
   Pan, Deyu
TI Reversal of age-associated oxidative stress in mice by PFT, a novel
   kefir product
SO INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY
LA English
DT Article
DE aging; antioxidants; oxidative stress; PFT
ID LACTIC-ACID BACTERIA; FREE-RADICAL THEORY; ANTIOXIDANT ACTIVITIES;
   GLUTATHIONE AEROSOL; LIPID-PEROXIDATION; METABOLIC SYNDROME; PROTECTIVE
   ROLE; DNA-DAMAGE; CHOLESTEROL; CELLS
AB Introduction: Oxidative stress is a key contributor to aging and age-related diseases. In the present study, we examine the protective effects of PFT, a novel kefir product, against age-associated oxidative stress using aged (10-month-old) mice. Methods: Mice were treated with PFT orally at a daily dose of 2 mg/kg body weight over 6 weeks, and antioxidant status, protein oxidation, and lipid peroxidation were studied in the brain, liver, and blood. Results: PFT supplementation significantly reduced the oxidative stress biomarkers malondialdehyde (MDA) and nitric oxide; reversed the reductions in glutathione (GSH) levels, total antioxidant capacity (TAC), and anti-hydroxyl radical (AHR) content; enhanced the antioxidant enzyme activities of glutathione peroxidase (GPx), catalase (CAT), and superoxide dismutase (SOD); inhibited the liver enzyme levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT); significantly reduced triglyceride (TG), total cholesterol (TC), and low density lipoprotein (LDL) levels; and significantly elevated high density lipoprotein (HDL) levels. Interestingly, PFT supplementation reversed the oxidative changes associated with aging, thus bringing levels to within the limits of the young control mice in the brain, liver, and blood. We also note that PFT affects the redox homeostasis of young mice and that it is corrected post-treatment with PFT. Conclusion: Our findings show the effectiveness of dietary PFT supplementation in modulating age-associated oxidative stress in mice and motivate further studies of PFT's effects in reducing age-associated disorders where free radicals and oxidative stress are the major cause.
C1 [Ghoneum, Mamdooh] Charles R Drew Univ Med & Sci, Dept Surg, 1621 E 120th St, Los Angeles, CA 90059 USA.
   [Abdulmalek, Shaymaa] Alexandria Univ, Fac Sci, Dept Biochem, Alexandria, Egypt.
   [Pan, Deyu] Charles R Drew Univ Med & Sci, Dept Prevent & Social Med, 1621 E 120th St, Los Angeles, CA 90059 USA.
C3 Charles R. Drew University of Medicine & Science; Egyptian Knowledge
   Bank (EKB); Alexandria University; Charles R. Drew University of
   Medicine & Science
RP Ghoneum, M (corresponding author), Charles R Drew Univ Med & Sci, Dept Surg, 1621 E 120th St, Los Angeles, CA 90059 USA.
EM mghoneum@ucla.edu
RI Pan, Deyu/LNP-8460-2024
FU National Institutes of Health-National Institute on Minority Health and
   Health Disparities [U54MD007598, S21MD000103]
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: The
   present study was partially supported by the National Institutes of
   Health-National Institute on Minority Health and Health Disparities
   (grant nos. U54MD007598 and S21MD000103).
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NR 81
TC 19
Z9 19
U1 1
U2 10
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0394-6320
EI 2058-7384
J9 INT J IMMUNOPATH PH
JI Int. J. Immunopathol. Pharmacol.
PD AUG
PY 2020
VL 34
AR 2058738420950149
DI 10.1177/2058738420950149
PG 17
WC Immunology; Pathology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Pathology; Pharmacology & Pharmacy
GA NM2PF
UT WOS:000567943200001
PM 32862733
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Zhao, YL
   Zhang, L
   Qiao, Y
   Zhou, XL
   Wu, GD
   Wang, LJ
   Peng, YH
   Dong, XL
   Huang, H
   Si, LN
   Zhang, XY
   Zhang, L
   Li, JH
   Wang, W
   Zhou, LY
   Gao, X
AF Zhao, Yanli
   Zhang, Lina
   Qiao, Yu
   Zhou, Xiaoling
   Wu, Guodong
   Wang, Lujing
   Peng, Yahui
   Dong, Xingli
   Huang, Hui
   Si, Lining
   Zhang, Xueying
   Zhang, Lei
   Li, Jihong
   Wang, Wei
   Zhou, Lingyun
   Gao, Xu
TI Heme Oxygenase-1 Prevents Cardiac Dysfunction in Streptozotocin-Diabetic
   Mice by Reducing Inflammation, Oxidative Stress, Apoptosis and Enhancing
   Autophagy
SO PLOS ONE
LA English
DT Article
ID SIGNALING PATHWAY; NADPH OXIDASE; CELL-DEATH; PROTECTIVE ROLE;
   GROWTH-FACTOR; CARDIOMYOPATHY; HEART; MECHANISMS; EXPRESSION; KINASE
AB Heme oxygenase-1 (HO-1) has been implicated in cardiac dysfunction, oxidative stress, inflammation, apoptosis and autophagy associated with heart failure, and atherosclerosis, in addition to its recognized role in metabolic syndrome and diabetes. Numerous studies have presented contradictory findings about the role of HO-1 in diabetic cardiomyopathy (DCM). In this study, we explored the role of HO-1 in myocardial dysfunction, myofibril structure, oxidative stress, inflammation, apoptosis and autophagy using a streptozotocin (STZ)-induced diabetes model in mice systemically overexpressing HO-1 (Tg-HO-1) or mutant HO-1 (Tg-mutHO-1). The diabetic mouse model was induced by multiple peritoneal injections of STZ. Two months after injection, left ventricular (LV) function was measured by echocardiography. In addition, molecular biomarkers related to oxidative stress, inflammation, apoptosis and autophagy were evaluated using classical molecular biological/biochemical techniques. Mice with DCM exhibited severe LV dysfunction, myofibril structure disarray, aberrant cardiac oxidative stress, inflammation, apoptosis, autophagy and increased levels of HO-1. In addition, we determined that systemic overexpression of HO-1 ameliorated left ventricular dysfunction, myofibril structure disarray, oxidative stress, inflammation, apoptosis and autophagy in DCM mice. Furthermore, serine/threonine-specific protein kinase (Akt) and AMP-activated protein kinase (AMPK) phosphorylation is normally inhibited in DCM, but overexpression of the HO-1 gene restored the phosphorylation of these kinases to normal levels. In contrast, the functions of HO-1 in DCM were significantly reversed by overexpression of mutant HO-1. This study underlines the unique roles of HO-1, including the inhibition of oxidative stress, inflammation and apoptosis and the enhancement of autophagy, in the pathogenesis of DCM.
C1 [Zhao, Yanli; Zhang, Lina; Qiao, Yu; Zhou, Xiaoling; Wu, Guodong; Wang, Lujing; Peng, Yahui; Dong, Xingli; Huang, Hui; Zhang, Xueying; Zhang, Lei; Li, Jihong; Wang, Wei; Zhou, Lingyun; Gao, Xu] Harbin Med Univ, Dept Biochem, Harbin, Heilongjiang, Peoples R China.
   [Zhao, Yanli] Qinghai Univ, Coll Med, Dept Biochem, Xining, Qinghai, Peoples R China.
   [Gao, Xu] Harbin Med Univ, Minist Educ, Key Lab Cardiovasc Med Res, Harbin, Heilongjiang, Peoples R China.
   [Gao, Xu] Harbin Med Univ, State Prov Key Labs Biomed Pharmaceut China, Harbin, Heilongjiang, Peoples R China.
   [Si, Lining] Qinghai Univ, Sch Med, Affiliated Hosp, Dept Critical Care Med, Xining, Qinghai, Peoples R China.
   [Zhang, Lina] Daqing Oilfield Gen Hosp, Dept Clin Lab, Daqing, Heilongjiang, Peoples R China.
C3 Harbin Medical University; Qinghai University; Harbin Medical
   University; Ministry of Education - China; Harbin Medical University;
   Qinghai University
RP Zhou, LY (corresponding author), Harbin Med Univ, Dept Biochem, Harbin, Heilongjiang, Peoples R China.
EM zhoulingy@tom.com; gaoxu_671227@163.com
RI Dong, Xingli/AAH-8374-2021; si, lining/GWD-0263-2022; Zhang,
   Lei/KPA-4277-2024; Qiao, Yu/O-2445-2015; Zhang, Xueying/AAK-1725-2021;
   gao, xu/U-4765-2019; Wu, Guodong/U-6549-2018; zhou,
   lingyun/AEL-8667-2022
OI Dong, Xingli/0000-0003-4525-5958
FU National Natural Science Foundation of Regional China [81060162,
   81001033]; Natural Science Foundation of Innovation Team of China
   [81121003]
FX This work was supported by the National Natural Science Foundation of
   Regional China (No.81060162, No.81001033) and the Natural Science
   Foundation of Innovation Team of China (No.81121003). The funders had no
   role in study design, data collection and analysis, decision to publish,
   or preparation of the manuscript.
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NR 73
TC 114
Z9 127
U1 0
U2 49
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD SEP 24
PY 2013
VL 8
IS 9
AR e75927
DI 10.1371/journal.pone.0075927
PG 12
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 226HG
UT WOS:000325025200071
PM 24086665
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Ilari, S
   Proietti, S
   Milani, F
   Vitiello, L
   Muscoli, C
   Russo, P
   Bonassi, S
AF Ilari, Sara
   Proietti, Stefania
   Milani, Francesca
   Vitiello, Laura
   Muscoli, Carolina
   Russo, Patrizia
   Bonassi, Stefano
TI Dietary Patterns, Oxidative Stress, and Early Inflammation: A Systematic
   Review and Meta-Analysis Comparing Mediterranean, Vegan, and Vegetarian
   Diets
SO NUTRIENTS
LA English
DT Review
DE oxidative stress; inflammation; Mediterranean diet; vegetarian diet;
   vegan diet; plant-based diet; healthy subject
ID CARDIOVASCULAR RISK PROFILE; LACTO-OVO-VEGETARIAN; METABOLIC SYNDROME;
   LIFE-STYLE; BIOMARKERS; DISEASE; ASSOCIATION; PREVENTION; HEALTHY;
   MARKERS
AB Background: Dietary habits influenced by lifestyle and cultural factors play a critical role in health by modulating oxidative stress and inflammation. While diets offer significant benefits, they may also pose risks, such as nutrient deficiencies, emphasizing the need for a balanced approach. Exploring Mediterranean and plant-based diet effects on oxidative stress and inflammation biomarkers may help improve health outcomes and disease prevention strategies. Methods: This study analyzed 65 studies following PRISMA guidelines to evaluate the effects of Mediterranean and plant-based diets on biomarkers of oxidative stress and inflammation in healthy individuals. Results: The Mediterranean diet was weakly associated with reductions in oxidative stress markers, including MDA (ROM: 0.80; 95% CI: 0.57-1.13; p = 0.2092) and 8OHdG (ROM: 0.81; 95% CI: 0.59-1.11; p = 0.1847), as well as inflammation markers such as CRP (ROM: 0.72; 95% CI: 0.42-1.23; p = 0.1545) and IL-6 (ROM: 1.23; 95% CI: 0.97-1.55; p = 0.08). The vegetarian diet significantly reduced CRP (ROM: 0.82; 95% CI: 0.69-0.98; p = 0.0297), while the vegan diet showed a borderline reduction (ROM: 0.81; 95% CI: 0.56-1.17; p = 0.2544), suggesting lower systemic inflammation compared to omnivorous diets. Conclusions: Although all three diets demonstrate potential in reducing oxidative stress and inflammation, the antioxidant effects-especially for the Mediterranean diet-are lower than anticipated, indicating alternative mechanisms. Further research is essential to confirm these findings and clarify the underlying mechanisms to enhance preventive health strategies.
C1 [Ilari, Sara; Milani, Francesca; Vitiello, Laura; Russo, Patrizia; Bonassi, Stefano] San Raffaele Univ, Dept Human Sci & Qual Life Promot, I-00166 Rome, Italy.
   [Ilari, Sara] IRCCS San Raffaele Roma, Pain Physiol & Pharmacol, I-00166 Rome, Italy.
   [Proietti, Stefania] Agea, Coordinating Body, I-00185 Rome, Italy.
   [Milani, Francesca; Vitiello, Laura; Russo, Patrizia; Bonassi, Stefano] IRCCS San Raffaele Roma, Clin & Mol Epidemiol, Via Val Cannuta 247, I-00166 Rome, Italy.
   [Muscoli, Carolina] Magna Graecia Univ Catanzaro, Inst Res Food Safety & Hlth IRC FSH, Dept Hlth Sci, I-88100 Catanzaro, Italy.
C3 Vita-Salute San Raffaele University; IRCCS San Raffaele Pisana; IRCCS
   San Raffaele Pisana; Magna Graecia University of Catanzaro
RP Russo, P (corresponding author), San Raffaele Univ, Dept Human Sci & Qual Life Promot, I-00166 Rome, Italy.; Russo, P (corresponding author), IRCCS San Raffaele Roma, Clin & Mol Epidemiol, Via Val Cannuta 247, I-00166 Rome, Italy.
EM sara.ilari@sanraffaele.it; s.proietti@agea.gov.it;
   francesca.milani@uniroma5.it; laura.vitiello@uniroma5.it;
   muscoli@unicz.it; patrizia.russo@uniroma5.it;
   stefano.bonassi@uniroma5.it
RI Vitiello, Laura/G-7326-2014; Bonassi, Stefano/ABI-6281-2020; Muscoli,
   Carolina/G-2773-2011; proietti, stefania/A-9194-2019; ilari,
   sara/C-2628-2017
OI Muscoli, Carolina/0000-0002-1047-4467; bonassi,
   stefano/0000-0003-3833-6717
FU Italian Ministry of Health [Ricerca Corrente]; PRIN 2022 [202273HF83];
   Missione 4 Componente 1 CUP [B83C22002820006]
FX This study was supported by the Italian Ministry of Health [Ricerca
   Corrente] (SI, PR, SB); PRIN 2022 (grant code: 202273HF83); and PRODIGI
   "Finanziato dall'Unione europea-Next Generation EU, Missione 4
   Componente 1 CUP B83C22002820006".
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NR 84
TC 4
Z9 4
U1 2
U2 2
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD FEB
PY 2025
VL 17
IS 3
AR 548
DI 10.3390/nu17030548
PG 27
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA W5E4B
UT WOS:001418802300001
PM 39940408
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU López-Domènech, S
   Abad-Jiménez, Z
   Iannantuoni, F
   de Marañón, AM
   Rovira-Llopis, S
   Morillas, C
   Bañuls, C
   Victor, VM
   Rocha, M
AF Lopez-Domenech, Sandra
   Abad-Jimenez, Zaida
   Iannantuoni, Francesca
   de Maranon, Aranzazu M.
   Rovira-Llopis, Susana
   Morillas, Carlos
   Banuls, Celia
   Manuel Victor, Victor
   Rocha, Milagros
TI Moderate weight loss attenuates chronic endoplasmic reticulum stress and
   mitochondrial dysfunction in human obesity
SO MOLECULAR METABOLISM
LA English
DT Article
DE Diet; Inflammation; Endoplasmic reticulum; Oxidative stress;
   Mitochondria
ID INSULIN-RESISTANCE; ADIPOSE-TISSUE; METABOLIC SYNDROME; ER STRESS;
   EXPRESSION; PROTEIN; COMPLEMENT; JNK; C3; INFLAMMATION
AB Objective: In obese patients undergoing caloric restriction, there are several potential mechanisms involved in the improvement of metabolic outcomes. The present study further explores whether caloric restriction can modulate endoplasmic reticulum (ER) stress and mitochondrial function, as both are known to be mechanisms underlying inflammation and insulin resistance (IR) during obesity.
   Methods: A total of 64 obese patients with BMI >= 35 kg/m(2) underwent a dietary program consisting of 6 weeks of a very-low-calorie diet followed by 18 weeks of low-calorie diet. We evaluated changes in the metabolic and inflammatory markers -TNF alpha, hsCRP, complement component 3 (C3c), and retinol binding protein 4 (RBP4)-, in the ER stress markers and modulators -eIF2 alpha-P, sXBP1, ATF6, JNK-P, CHOP, GRP78, and SIRT1-, and in mitochondrial function parameters-mitochondrial reactive oxygen species (mROS), glutathione peroxidase 1 (GPX1), cytosolic Ca2+, and mitochondrial membrane potential.
   Results: The dietary intervention produced an 8.85% weight loss associated with enhanced insulin sensitivity, a less marked atherogenic lipid profile, and a decrease in systemic inflammation (TNF alpha, hsCRP) and adipokine levels (RBP4 and C3c). Chronic ER stress was significantly reduced (ATF6-CHOP, JNK-P) and expression levels of SIRT1 and GRP78 - a Ca2+-dependent chaperone - were increased and accompanied by the restoration of Ca2+ depots. Furthermore, mROS production and mitochondrial membrane potential improvement were associated with the up-regulation of the antioxidant enzyme GPX1.
   Conclusions: Our data provide evidence that moderate weight loss attenuates systemic inflammation and IR and promotes the amelioration of ER stress and mitochondrial dysfunction, increasing the expression of chaperones, SIRT1 and antioxidant GPX1. (C) 2018 The Authors. Published by Elsevier GmbH.
C1 [Lopez-Domenech, Sandra; Abad-Jimenez, Zaida; Iannantuoni, Francesca; de Maranon, Aranzazu M.; Rovira-Llopis, Susana; Morillas, Carlos; Banuls, Celia; Manuel Victor, Victor; Rocha, Milagros] Univ Hosp Doctor Peset FISABIO, Dept Endocrinol & Nutr, Avda Gaspar Aguilar 90, Valencia 46017, Spain.
   [Manuel Victor, Victor; Rocha, Milagros] Univ Valencia, CIBER CB06 04 0071 Res Grp, CIBER Hepat & Digest Dis, Av Blasco Ibanez 13, Valencia 46010, Spain.
   [Manuel Victor, Victor] Univ Valencia, Dept Physiol, Av Blasco Ibanez 13, Valencia 46010, Spain.
C3 CIBER - Centro de Investigacion Biomedica en Red; CIBEREHD; University
   of Valencia; University of Valencia
RP Victor, VM; Rocha, M (corresponding author), Univ Hosp Doctor Peset FISABIO, Dept Endocrinol & Nutr, Avda Gaspar Aguilar 90, Valencia 46017, Spain.
EM victor.victor@uv.es; milagros.rocha@uv.es
RI Morillas, Carlos/ABF-3504-2020; victor, victor/Q-4843-2019; Domènech,
   Sandra/AAA-9732-2020; Banuls, Celia/H-7359-2017; Rovira-Llopis,
   Susana/AAX-8666-2021; Rocha, Milagros/I-4987-2015; Martinez de Maranon
   Peris, Aranzazu/H-4399-2017
OI Banuls, Celia/0000-0001-8077-7642; Rovira-Llopis,
   Susana/0000-0002-8476-5128; Morillas, Carlos/0000-0002-3745-4423; Lopez
   Domenech, Sandra/0000-0003-2067-9308; Iannantuoni,
   Francesca/0000-0002-9107-9011; Rocha, Milagros/0000-0003-2923-6546;
   Martinez de Maranon Peris, Aranzazu/0000-0002-4153-0396
FU Carlos III Health Institute [PI16/00301, PI16/01083, FI14/00350,
   FI17/00144, FI17/00126, CPII16/0037]; European Regional Development Fund
   (ERDF "A way to build Europe"); Regional Ministry Education of Valencian
   Community [PROMETEOII 2014/035, GRISOLIAP/2016/015]; Spanish Ministry of
   Economy and Competitiveness [FJCI-2015-25040]; Menarini S.A.
FX The authors acknowledge the editorial assistance of Brian Normanly
   (CIBERehd) and the technical support of Rosa Falcon. This study was
   supported by grant PI16/00301 and PI16/01083 from Carlos III Health
   Institute and has been co-funded by the European Regional Development
   Fund (ERDF "A way to build Europe") and PROMETEOII 2014/035 from the
   Regional Ministry Education of Valencian Community. SLD, ZA-J and AM are
   recipients of predoctoral fellowship from Carlos III Health Institute
   (FI14/00350, FI17/00144, FI17/00126). FI is recipient of a predoctoral
   fellowship from the Regional Ministry Education of Valencian Community
   (GRISOLIAP/2016/015). SR-L is recipient of a Juan de la Cierva-Formacion
   contract from the Spanish Ministry of Economy and Competitiveness
   (FJCI-2015-25040). MR is recipient of a Miguel Servet (CPII16/0037)
   contract from Carlos III Health Institute. Unrestricted grant from
   Menarini S.A. The authors declare no potential conflicts of interest
   with respect to the authorship and/or publication of this article.
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NR 56
TC 35
Z9 36
U1 0
U2 17
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2212-8778
J9 MOL METAB
JI Mol. Metab.
PD JAN
PY 2019
VL 19
BP 24
EP 33
DI 10.1016/j.molmet.2018.10.005
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA HG4GC
UT WOS:000454932400003
PM 30385096
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Jia, S
   Jin, LY
   Cheng, XY
   Wu, JY
   Yao, XK
   Shao, JP
   Zhang, CC
   Cen, DW
   Cheng, B
   Wang, J
   Chen, L
   Yao, XM
AF Jia, Shu
   Jin, Lianyu
   Cheng, Xiaoyan
   Wu, Jingyi
   Yao, Xiaokun
   Shao, Jingping
   Zhang, Congcong
   Cen, Danwei
   Cheng, Bin
   Wang, Jing
   Chen, Lei
   Yao, Xiaomin
TI Bicyclol alleviates high-fat diet-induced hepatic ER stress- and
   autophagy-associated non-alcoholic fatty liver disease/non-alcoholic
   steatohepatitis in mice
SO DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
LA English
DT Article
DE Bicyclol; NASH; ER stress; autophagy; apoptosis
ID ENDOPLASMIC-RETICULUM STRESS; MECHANISM; INJURY; EPIDEMIOLOGY;
   PATHOGENESIS; INHIBITION; APOPTOSIS; FIBROSIS
AB Background and objective: Non-alcoholic fatty liver disease (NAFLD) is a manifestation of the metabolic syndrome in the liver, and non-alcoholic steatohepatitis (NASH) represents its advanced stage. Bicyclol has protective activity against NAFLD in mice; however, the effect of bicyclol on high-fat diet (HFD)-induced NASH and its underlying molecular mechanism remains unknown particularly anti-endoplasmic reticulum (ER) stress and autophagic machinery potentials. Therefore, the present study was performed to investigate the protective effect and underlying mechanisms of bicyclol action on NAFLD/NASH.
   Methods: Mice were fed an HFD to induce NAFLD/NASH, and bicyclol was administered as a treatment. Biochemistry and histopathological assays were performed to evaluate the effects of bicyclol on NAFLD/NASH. Moreover, the levels of hepatic ER stress- and autophagy-related markers were determined by western blotting.
   Results: The present results revealed that bicyclol exerted significant protective effects against HFD-induced NAFLD/NASH. This activity was evidenced by the decrease in elevated serum transaminase and hepatic triglyceride levels, and the attenuation of negative histopathological changes. Bicyclol considerably alleviated hepatic inflammation and apoptosis. The protein expression of ER stress-related markers, including C/EBP homologous protein (CHOP) and glucose-regulated protein 78 (GRP78), was downregulated by the bicyclol treatment in HFD-induced mice. However, the protein expression of autophagy-related markers (LC3 and Beclin 1) was upregulated by the treatment with bicyclol.
   Conclusion: Bicyclol protected HFD-induced NASH, and partly due to its ability of reducing ER stress and promoting autophagy.
C1 [Jia, Shu; Wu, Jingyi; Yao, Xiaokun; Shao, Jingping; Zhang, Congcong; Cen, Danwei; Cheng, Bin; Chen, Lei; Yao, Xiaomin] Zhejiang Pharmaceut Coll, Fac Pharm, 888 Yinxian Rd, Ningbo, Peoples R China.
   [Jin, Lianyu] Ningbo Yinzhou 2 Hosp, Ningbo, Peoples R China.
   [Cheng, Xiaoyan] Beijing Ctr Phys & Chem Anal, Beijing, Peoples R China.
   [Wang, Jing] Ningbo Univ, Peoples Hosp, Ningbo, Peoples R China.
C3 Beijing Academy of Science & Technology; Ningbo University
RP Yao, XM (corresponding author), Zhejiang Pharmaceut Coll, Fac Pharm, 888 Yinxian Rd, Ningbo, Peoples R China.
EM 630088408@qq.com
RI Zhang, Congcong/AAL-7032-2020
FU Ningbo Natural Science Foundation [202003N4336, 2019A610223,
   2019A610211, 2019A610350, 2018A610235, 2016A610240]; Zhejiang Provincial
   Medicine and Health Technology Project [2020RC106]; Basic Public Welfare
   Project of Zhejiang Province [LGF22H310003]; Ningbo Science and
   Technology Program Public Welfare Project [2019C50066, 2021S098];
   Zhejiang University Student Science and Technology Innovation Activity
   Plan [2018R458002, 2021R460001]
FX This work was supported by the Ningbo Natural Science Foundation (Grant
   No. 202003N4336, 2019A610223, 2019A610211, 2019A610350, 2018A610235, and
   2016A610240), the Zhejiang Provincial Medicine and Health Technology
   Project (Grant No. 2020RC106), Basic Public Welfare Project of Zhejiang
   Province (Grant No. LGF22H310003), the Ningbo Science and Technology
   Program Public Welfare Project (Grant No. 2019C50066 and 2021S098), and
   the Zhejiang University Student Science and Technology Innovation
   Activity Plan (Grant No. 2018R458002 and 2021R460001).
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NR 40
TC 7
Z9 7
U1 1
U2 9
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0363-9045
EI 1520-5762
J9 DRUG DEV IND PHARM
JI Drug Dev. Ind. Pharm.
PD JUN 3
PY 2022
VL 48
IS 6
BP 247
EP 254
DI 10.1080/03639045.2022.2106238
EA AUG 2022
PG 8
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 4N0GN
UT WOS:000836053600001
PM 35875932
DA 2025-06-11
ER

PT J
AU Sato, M
   Kawakami, T
   Kondoh, M
   Takiguchi, M
   Kadota, Y
   Himeno, S
   Suzuki, S
AF Sato, Masao
   Kawakami, Takashige
   Kondoh, Masuo
   Takiguchi, Masufumi
   Kadota, Yoshito
   Himeno, Seiichiro
   Suzuki, Shinya
TI Development of high-fat-diet-induced obesity in female
   metallothionein-null mice
SO FASEB JOURNAL
LA English
DT Article
DE mesoderm-specific transcript; adipose tissues; leptin resistance;
   oxidative stress
ID ENDOPLASMIC-RETICULUM STRESS; MESSENGER-RNA EXPRESSION;
   INSULIN-RESISTANCE; PPAR-GAMMA; GENE-EXPRESSION; OXIDATIVE STRESS;
   ADIPOCYTE DIFFERENTIATION; METABOLIC SYNDROME; ADIPOSE-TISSUE; ER STRESS
AB Oxidative stress accelerates adipocyte differentiation and lipid accumulation, leading to endoplasmic reticulum (ER) stress, which causes insulin resistance. Because metallothionein (MT) has a role in prevention of oxidative and ER stress, we examined the effects of MT on the development of obesity induced by 27 wk of a high-fat diet (HFD) in female MT-I- and MT-II-null (MT-/-) and wild-type (MT+/+) mice. Body weight, fat mass, and plasma cholesterol increased at a greater rate in MT-/- mice fed an HFD than in MT-/- mice fed a control diet (CD) and MT+/+ mice fed an HFD, indicating that MT-/- mice fed an HFD became obese and hypercholesterolemic and that MT could prevent HFD-induced obesity. The observed increases in the levels of plasma leptin and leptin mRNA in the white adipose tissue of MT-/- mice fed the HFD suggested a leptin-resistant state. Enhanced expression of a mesoderm-specific transcript, which regulates the enlargement of fat cells, was accompanied by enlarged adipocytes in the white adipose tissue of young MT-/- mice before obesity developed after 3 and 8 wk of feeding the HFD. Thus, MT may have a preventive role against HFD-induced obesity by regulating adipocyte enlargement and leptin signaling.-Sato, M., Kawakami, T., Kondoh, M., Takiguchi, M., Kadota, Y., Himeno, S., Suzuki, S. Development of high-fat-diet-induced obesity in female metallothionein-null mice. FASEB J. 24, 2375-2384 (2010). www.fasebj.org
C1 [Sato, Masao; Kawakami, Takashige; Kondoh, Masuo; Takiguchi, Masufumi; Kadota, Yoshito; Himeno, Seiichiro; Suzuki, Shinya] Tokushima Bunri Univ, Fac Pharmaceut Sci, Tokushima 7708514, Japan.
C3 Tokushima Bunri University
RP Sato, M (corresponding author), Tokushima Bunri Univ, Fac Pharmaceut Sci, 180 Yamashiro Cho, Tokushima 7708514, Japan.
EM msato@ph.bunri-u.ac.jp
RI Himeno, Seiichiro/AAW-3421-2020
OI Kadota, Yoshito/0000-0002-2721-4100; Himeno,
   Seiichiro/0000-0002-0773-2373
FU Ministry of Education, Science, Sports, and Culture of Japan [1430767]
FX The authors thank K. Setsu, M. Inoue, T. Abe (Tokushima Bunri
   University, Tokushima, Japan) and K. Suzuki (Gunma University, Maebashi,
   Japan) for their assistance in histology, and M. Higashimoto, M. Mori,
   S. Ishibashi, Y. Wakuta, Y. Tsubakizaki, and K. Yoshikawa (Tokushima
   Bunri University) and M. Mita (Kitasato University, Tokyo, Japan) for
   their excellent technical assistance and mouse husbandry. This work was
   supported in part by a Grant-in-Aid for General Scientific Research from
   the Ministry of Education, Science, Sports, and Culture of Japan
   (1430767; to M. S.). All authors contributed equally to this work.
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NR 51
TC 70
Z9 76
U1 0
U2 3
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
EI 1530-6860
J9 FASEB J
JI Faseb J.
PD JUL
PY 2010
VL 24
IS 7
BP 2375
EP 2384
DI 10.1096/fj.09-145466
PG 10
WC Biochemistry & Molecular Biology; Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 618HV
UT WOS:000279343600024
PM 20219986
DA 2025-06-11
ER

PT J
AU Flessa, CM
   Kyrou, I
   Nasiri-Ansari, N
   Kaltsas, G
   Kassi, E
   Randeva, HS
AF Flessa, Christina-Maria
   Kyrou, Ioannis
   Nasiri-Ansari, Narjes
   Kaltsas, Gregory
   Kassi, Eva
   Randeva, Harpal S.
TI Endoplasmic reticulum stress in nonalcoholic (metabolic associated)
   fatty liver disease (NAFLD/MAFLD)
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Review
DE autophagy; circadian clock; ER stress; lipotoxicity; NAFLD; pyroptosis
ID UNFOLDED PROTEIN RESPONSE; HEPATIC STELLATE CELLS; NF-KAPPA-B; ER
   STRESS; LIPID-METABOLISM; INSULIN-RESISTANCE; KUPFFER CELLS;
   HEPATOCELLULAR-CARCINOMA; NLRP3 INFLAMMASOME; OXIDATIVE STRESS
AB Nonalcoholic fatty liver disease (NAFLD) is characterized by hepatic fat accumulation in the absence of excessive alcohol consumption and is strongly associated with obesity, type 2 diabetes (T2DM) and other metabolic syndrome features. NAFLD is becoming increasingly prevalent and currently constitutes the leading cause of hepatocellular carcinoma (HCC). Recently, the term metabolic (dysfunction) associated fatty liver disease (MAFLD) has been proposed reflecting more accurately the underlying pathogenesis and the cardiometabolic disorders associated to NAFLD/MAFLD. Given the vital metabolic functions of the liver to maintain the body homeostasis, an extended endoplasmic reticulum (ER) network is mandatory in hepatocytes to retain its capacity to adapt to the multiple extracellular and intracellular signals mediating metabolic changes. Dysfunction of hepatocyte ER homeostasis and disturbance of its interaction with mitochondria have been recognized to be involved in the NAFLD pathophysiology. Apart from hepatocytes, hepatic stellate cells, and Kupffer cells have been shown to play an important role in the occurrence of NAFLD and progression to nonalcoholic steatohepatitis (NASH) with possibly different roles in the different stages of the NAFLD spectrum. Furthermore, excess lipid accumulation in the liver causes lipotoxicity which interacts with ER stress and culminates in inflammation and hepatocellular damage, mechanisms crucially implicated in NASH pathogenesis. Finally, the circadian clock machinery regulates ER stress-related pathways and vice versa, thus controlling the homeostasis of the liver metabolism and being implicated in the NAFLD progression. This review presents a comprehensive overview of the current knowledge supporting the impact of ER stress signaling on NAFLD, whilst summarizing potential therapeutic interventions targeting this process.
C1 [Flessa, Christina-Maria; Nasiri-Ansari, Narjes; Kassi, Eva] Natl & Kapodistrian Univ Athens, Sch Med, Dept Biol Chem, Athens 11527, Greece.
   [Flessa, Christina-Maria; Kyrou, Ioannis; Randeva, Harpal S.] Univ Hosp Coventry & Warwickshire NHS Trust, Warwickshire Inst Study Diabet Endocrinol & Metab, Coventry CV2 2DX, W Midlands, England.
   [Kyrou, Ioannis; Randeva, Harpal S.] Univ Warwick, Warwick Med Sch, Div Translat & Expt Med Metab & Vasc Hlth, Coventry, W Midlands, England.
   [Kyrou, Ioannis] Coventry Univ, Res Inst Hlth & Wellbeing, Ctr Sport Exercise & Life Sci, Coventry, W Midlands, England.
   [Kyrou, Ioannis] Aston Univ, Aston Med Sch, Coll Hlth & Life Sci, Birmingham, W Midlands, England.
   [Kyrou, Ioannis] Agr Univ Athens, Dept Food Sci & Human Nutr, Athens, Greece.
   [Kaltsas, Gregory; Kassi, Eva] Natl & Kapodistrian Univ Athens, Laiko Hosp, Dept Propaedeut & Internal Med 1, Endocrine Unit, Athens, Greece.
C3 Athens Medical School; National & Kapodistrian University of Athens;
   University of Warwick; University of Warwick; Coventry University; Aston
   University; Agricultural University of Athens; Laiko General Hospital;
   National & Kapodistrian University of Athens
RP Kassi, E (corresponding author), Natl & Kapodistrian Univ Athens, Sch Med, Dept Biol Chem, Athens 11527, Greece.; Randeva, HS (corresponding author), Univ Hosp Coventry & Warwickshire NHS Trust, Warwickshire Inst Study Diabet Endocrinol & Metab, Coventry CV2 2DX, W Midlands, England.
EM ekassi@med.uoa.gr; harpal.randeva@uhcw.nhs.uk
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NR 176
TC 45
Z9 46
U1 5
U2 43
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0730-2312
EI 1097-4644
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PD OCT
PY 2022
VL 123
IS 10
SI SI
BP 1585
EP 1606
DI 10.1002/jcb.30247
EA MAY 2022
PG 22
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA 5R5ED
UT WOS:000789117800001
PM 35490371
DA 2025-06-11
ER

PT J
AU Namgaladze, D
   Lips, S
   Leiker, TJ
   Murphy, RC
   Ekroos, K
   Ferreiros, N
   Geisslinger, G
   Brüne, B
AF Namgaladze, Dmitry
   Lips, Sebastian
   Leiker, Thomas J.
   Murphy, Robert C.
   Ekroos, Kim
   Ferreiros, Nerea
   Geisslinger, Gerd
   Bruene, Bernhard
TI Inhibition of macrophage fatty acid β-oxidation exacerbates
   palmitate-induced inflammatory and endoplasmic reticulum stress
   responses
SO DIABETOLOGIA
LA English
DT Article
DE beta-Oxidation; Endoplasmic reticulum stress; Fatty acids; Inflammation;
   Macrophages
ID INDUCED INSULIN-RESISTANCE; METABOLIC DISEASE; MUSCLE-CELLS; APOPTOSIS;
   ACTIVATION; LINKS; MICE; TLR4; IDENTIFICATION; SENSITIVITY
AB Aims/hypothesis Saturated fatty acids (SFAs) such as palmitate activate inflammatory pathways and elicit an endoplasmic reticulum (ER) stress response in macrophages, thereby contributing to the development of insulin resistance linked to the metabolic syndrome. This study addressed the question of whether or not mitochondrial fatty acid beta-oxidation (FAO) affects macrophage responses to SFA.
   Methods We modulated the activity of carnitine palmitoyl transferase 1A (CPT1A) in macrophage-differentiated THP-1 monocytic cells using genetic or pharmacological approaches, treated the cells with palmitate and analysed the proinflammatory and ER stress signatures.
   Results To inhibit FAO, we created THP-1 cells with a stable knockdown (KD) of CPT1A and differentiated them to macrophages. Consequently, in CPT1A-silenced cells FAO was reduced. CPT1A KD in THP-1 macrophages increased proinflammatory signalling, cytokine expression and ER stress responses after palmitate treatment. In addition, in human primary macrophages CPT1A KD elevated palmitate-induced inflammatory gene expression. Pharmacological inhibition of FAO with etomoxir recapitulated the CPT1A KD phenotype. Conversely, overexpression of a malonyl-CoA-insensitive CPT1A M593S mutant reduced inflammatory and ER stress responses to palmitate in THP-1 macrophages. Macrophages with a CPT1A KD accumulated diacylglycerols and triacylglycerols after palmitate treatment, while ceramide accumulation remained unaltered. Moreover, lipidomic analysis of ER phospholipids revealed increased palmitate incorporation into phosphatidylethanolamine and phosphatidylserine classes associated with the CPT1A KD.
   Conclusions/interpretation Our data indicate that FAO attenuates inflammatory and ER stress responses in SFA-exposed macrophages, suggesting an anti-inflammatory impact of drugs that activate FAO.
C1 [Namgaladze, Dmitry; Lips, Sebastian; Bruene, Bernhard] Goethe Univ Frankfurt, Inst Biochem I ZAFES, Fac Med, D-60590 Frankfurt, Germany.
   [Leiker, Thomas J.; Murphy, Robert C.] Univ Colorado, Dept Pharmacol, Aurora, CO USA.
   [Ekroos, Kim] Zora Biosci Oy, Espoo, Finland.
   [Ferreiros, Nerea; Geisslinger, Gerd] Goethe Univ Frankfurt, Inst Clin Pharmacol, Pharmazentrum Frankfurt ZAFES, D-60590 Frankfurt, Germany.
C3 Goethe University Frankfurt; University of Colorado System; University
   of Colorado Anschutz Medical Campus; Goethe University Frankfurt
RP Brüne, B (corresponding author), Goethe Univ Frankfurt, Inst Biochem I ZAFES, Fac Med, Theodor Stern Kai 7, D-60590 Frankfurt, Germany.
EM bruene@pathobiochemie1.de
FU Deutsche Forschungsgemeinschaft [BR999]; Else Kroner Fresenius
   Foundation; US National Institutes of Health [GM006938]
FX This work was supported by grants from Deutsche Forschungsgemeinschaft
   (grant no. BR999) and by the Else Kroner Fresenius Foundation
   (Translational Research Innovation-Pharma [TRIP]). Mass spectrometric
   measurements of DAGs were supported by a grant (RCM) from the US
   National Institutes of Health (Lipid Maps, GM006938).
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NR 41
TC 65
Z9 71
U1 0
U2 24
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0012-186X
EI 1432-0428
J9 DIABETOLOGIA
JI Diabetologia
PD MAY
PY 2014
VL 57
IS 5
BP 1067
EP 1077
DI 10.1007/s00125-014-3173-4
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA AF1SV
UT WOS:000334494700026
PM 24488024
DA 2025-06-11
ER

PT J
AU Shonkoff, ET
   Dunton, GF
   Chou, CP
   Leventhal, AM
   Bluthenthal, R
   Pentz, MA
AF Shonkoff, Eleanor T.
   Dunton, Genevieve F.
   Chou, Chih-Ping
   Leventhal, Adam M.
   Bluthenthal, Ricky
   Pentz, Mary Ann
TI Direct and indirect effects of parent stress on child obesity risk and
   added sugar intake in a sample of Southern California adolescents
SO PUBLIC HEALTH NUTRITION
LA English
DT Article
DE Child obesity; Parenting practices; Parent stress; Added sugar; Waist
   circumference
ID CROSS-SECTIONAL ANALYSIS; BODY-MASS INDEX; PHYSICAL-ACTIVITY; FAMILY
   STRESS; US CHILDREN; SWEETENED BEVERAGES; WAIST CIRCUMFERENCE; METABOLIC
   SYNDROME; NATIONAL-HEALTH; DIETARY-INTAKE
AB Objective: Research indicates that children are at higher risk for obesity if their parents have been exposed to a larger number of stressors, yet little is known about effects of parents' subjective, perceived experience of stress on children's eating behaviours and adiposity and whether weight-related parenting practices (i.e. parent rules and positive family meal practices) mediate this relationship. The present study evaluated the direct and mediated relationship between parent perceived stress and child waist circumference and parent stress and child consumption of added sugars one year later.
   Design: Longitudinal panel data.
   Setting: Eleven communities in Southern California, USA.
   Subjects: Data were collected over two waves from parent-child dyads (n 599). Most parents were female (81 %) and Hispanic (51 %); children were 11 years old on average (sd 1.53; range 7-15 years) and 31 % received free school lunch.
   Results: Perceived parent stress was not significantly associated with child waist circumference or consumption of added sugars one year later, and mediating pathways through parenting practices were not significant. However, parent rules were significantly associated with lower child consumption of added sugars (beta = -0.14, P <0.001).
   Conclusions: Results suggest that parent rules about the types of foods children can eat, clearly explained to children, may decrease child consumption of added sugars but not necessarily lead to changes in obesity risk. Parent- and family-based interventions that support development of healthy rules about child eating have the potential to improve child dietary nutrient intake.
C1 [Shonkoff, Eleanor T.] Tufts Univ, Friedman Sch Nutr Sci & Policy, Child Obes 180,150 Harrison Ave, Boston, MA 02111 USA.
   [Dunton, Genevieve F.; Chou, Chih-Ping; Leventhal, Adam M.; Bluthenthal, Ricky; Pentz, Mary Ann] Univ Southern Calif, Dept Prevent Med, Los Angeles, CA 90089 USA.
C3 Tufts University; University of Southern California
RP Shonkoff, ET (corresponding author), Tufts Univ, Friedman Sch Nutr Sci & Policy, Child Obes 180,150 Harrison Ave, Boston, MA 02111 USA.
EM eleanor.shonkoff@tufts.edu
RI Bluthenthal, Ricky/U-8203-2018
OI Tate Shonkoff, Eleanor/0000-0003-4636-6668
FU National Institutes of Health Cancer Control and Epidemiology Research
   Training Grant [5 T32 CA 009492]; American Cancer Society
   [118283-MRSGT-10-012-01-CPPB]
FX This work was supported by a National Institutes of Health Cancer
   Control and Epidemiology Research Training Grant (Principal Investigator
   M.A.P., grant number 5 T32 CA 009492); and the American Cancer Society
   (Principal Investigator G.F.D., grant number
   #118283-MRSGT-10-012-01-CPPB). The funders had no role in the design,
   analysis or writing of this article.
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NR 72
TC 11
Z9 14
U1 1
U2 21
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 1368-9800
EI 1475-2727
J9 PUBLIC HEALTH NUTR
JI Public Health Nutr.
PD DEC
PY 2017
VL 20
IS 18
BP 3285
EP 3294
DI 10.1017/S136898001700252X
PG 10
WC Public, Environmental & Occupational Health; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; Nutrition & Dietetics
GA FT5MN
UT WOS:000423197700010
PM 28980520
OA Bronze, Green Accepted, Green Published
DA 2025-06-11
ER

PT J
AU Cui, YZ
   Wang, QJ
   Chang, RX
   Zhou, XC
   Xu, C
AF Cui, Yizhe
   Wang, Qiuju
   Chang, Renxu
   Zhou, Xiaocui
   Xu, Chuang
TI Intestinal Barrier Function-Non-alcoholic Fatty Liver Disease
   Interactions and Possible Role of Gut Microbiota
SO JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
LA English
DT Article
DE barrier function; intestinal microflora; gut-liver axis; oxidative
   stress; NAFLD
ID ANTIBIOTIC-ASSOCIATED DIARRHEA; NECROSIS-FACTOR-ALPHA; TOLL-LIKE
   RECEPTORS; DOUBLE-BLIND; NONALCOHOLIC STEATOHEPATITIS; BACTERIAL
   OVERGROWTH; BILE-ACIDS; PROBIOTICS; HOST; PERMEABILITY
AB Non-alcoholic fatty liver disease (NAFLD) is a metabolic stress liver injury that is closely related to obesity, insulin resistance, type 2 diabetes, atherosclerosis, and metabolic syndrome. The pathological features are diffuse hepatic vesicular steatosis, including non-alcoholic steatohepatitis, liver fibrosis, and even liver cancer. A variety of pathological outcomes cause serious harm to human health. At present, an increasing number of researchers are investigating the pathogenesis of NAFLD from the perspective of changes in the function of the intestinal barrier. The physical, chemical, immunological, and microbiological barriers in the intestinal tract constitute the complete intestinal barrier, which plays an important defensive role against the invasion of harmful substances from the intestines. Protecting the function of the intestinal barrier is a new way to treat NAFLD and its related diseases. In this perspective, we summarized the current knowledge of the role of the intestinal barrier in NAFLD.
C1 [Cui, Yizhe; Wang, Qiuju; Chang, Renxu; Xu, Chuang] Heilongjiang Bayi Agr Univ, Coll Anim Sci & Vet Med, 2 Xinyang Rd, Daqing 163319, Heilongjiang, Peoples R China.
   [Zhou, Xiaocui] China Anim Hlth & Epidemiol Ctr, Lab Zoonosis, Qingdao 266000, Shandong, Peoples R China.
C3 Heilongjiang Bayi Agricultural University; China Animal Health &
   Epidemiology Center
RP Xu, C (corresponding author), Heilongjiang Bayi Agr Univ, Coll Anim Sci & Vet Med, 2 Xinyang Rd, Daqing 163319, Heilongjiang, Peoples R China.
EM xuchuang7175@163.com
FU National Key R&D Program of China [2017YFD0502200]; Group Control
   Technology and Product Development and Demonstration of Important Mass
   Production Disease Groups in Dairy Cattle [GA16B20]; China Postdoctoral
   Science Foundation [2017M620124, 2018T110320]; Doctoral Program
   Foundation of Heilongjiang Bayi Agricultural University of China
   [XDB-2016-10]; Postdoctoral Program Foundation of Heilongjiang Bayi
   Agricultural University [601038]; Natural Science Foundation of
   Heilongjiang Province [C201444]
FX The work was financially supported in part by the National Key R&D
   Program of China (Grant 2017YFD0502200), the Group Control Technology
   and Product Development and Demonstration of Important Mass Production
   Disease Groups in Dairy Cattle (Grant GA16B20), the China Postdoctoral
   Science Foundation (Grants 2017M620124 and 2018T110320), the Doctoral
   Program Foundation of Heilongjiang Bayi Agricultural University of China
   (Grant XDB-2016-10), the Postdoctoral Program Foundation of Heilongjiang
   Bayi Agricultural University (Grant 601038), and the Natural Science
   Foundation of Heilongjiang Province (Grant C201444).
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NR 103
TC 152
Z9 163
U1 5
U2 197
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0021-8561
EI 1520-5118
J9 J AGR FOOD CHEM
JI J. Agric. Food Chem.
PD MAR 13
PY 2019
VL 67
IS 10
BP 2754
EP 2762
DI 10.1021/acs.jafc.9b00080
PG 9
WC Agriculture, Multidisciplinary; Chemistry, Applied; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture; Chemistry; Food Science & Technology
GA HP2XG
UT WOS:000461538100003
PM 30798598
OA Bronze
DA 2025-06-11
ER

PT S
AU Matthews, KA
   Gallo, LC
AF Matthews, Karen A.
   Gallo, Linda C.
BE Fiske, ST
   Schacter, DL
   Taylor, SE
TI Psychological Perspectives on Pathways Linking Socioeconomic Status and
   Physical Health
SO ANNUAL REVIEW OF PSYCHOLOGY, VOL 62
SE Annual Review of Psychology
LA English
DT Review; Book Chapter
DE stress; resources; emotions; inflammation; metabolic factors; sleep;
   race; gender; life course; socioeconomic status
ID NATIONALLY REPRESENTATIVE SAMPLE; CUMULATIVE BIOLOGICAL RISK; AMBULATORY
   BLOOD-PRESSURE; OBJECTIVE SOCIAL-STATUS; STRESSFUL LIFE EVENTS;
   MIDDLE-AGED WOMEN; METABOLIC SYNDROME; ALLOSTATIC LOAD;
   CARDIOVASCULAR-DISEASE; HEART-DISEASE
AB Low socioeconomic status (SES) is a reliable correlate of poor physical health. Rather than treat SES as a covariate, health psychology has increasingly focused on the psychobiological pathways that inform understanding why SES is related to physical health. This review assesses the status of research that has examined stress and its associated distress, and social and personal resources as pathways. It highlights work on biomarkers and biological pathways related to SES that can serve as intermediate outcomes in future studies. Recent emphasis on the accumulation of psychobiological risks across the life course is summarized and represents an important direction for future research. Studies that test pathways from SES to candidate psychosocial pathways to health outcomes are few in number but promising. Future research should test integrated models rather than taking piecemeal approaches to evidence. Much work remains to be done, but the questions are of great health significance.
C1 [Matthews, Karen A.] Univ Pittsburgh, Dept Psychiat, Pittsburgh, PA 15213 USA.
   [Gallo, Linda C.] San Diego State Univ, Dept Psychol, San Diego, CA 92120 USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE); University
   of Pittsburgh; California State University System; San Diego State
   University
RP Matthews, KA (corresponding author), Univ Pittsburgh, Dept Psychiat, 3811 Ohara St, Pittsburgh, PA 15213 USA.
EM matthewska@upmc.edu; lcgallo@sciences.sdsu.edu
OI Gallo, Linda C./0000-0002-3678-5888
FU NHLBI NIH HHS [R24 HL076852, HL025767, RC2 HL101649, R01 HL081604,
   HL076858, HL081604, HL076852, R24 HL076858, R01 HL025767, R56 HL081604,
   HL101649] Funding Source: Medline
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NR 155
TC 482
Z9 577
U1 6
U2 257
PU ANNUAL REVIEWS
PI PALO ALTO
PA 4139 EL CAMINO WAY, PO BOX 10139, PALO ALTO, CA 94303-0897 USA
SN 0066-4308
EI 1545-2085
BN 978-0-8243-0262-7
J9 ANNU REV PSYCHOL
JI Annu. Rev. Psychol
PY 2011
VL 62
BP 501
EP 530
DI 10.1146/annurev.psych.031809.130711
PG 30
WC Psychology; Psychology, Multidisciplinary
WE Book Citation Index – Social Sciences & Humanities (BKCI-SSH); Book Citation Index – Science (BKCI-S); Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology
GA BTM45
UT WOS:000287331200019
PM 20636127
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Love, KM
   Barrett, EJ
   Horton, WB
AF Love, Kaitlin M.
   Barrett, Eugene J.
   Horton, William B.
TI Metformin's Impact on the Microvascular Response to Insulin
SO ENDOCRINOLOGY
LA English
DT Review
DE metformin; microvessels; blood vessels; insulin resistance
ID ENDOTHELIAL DYSFUNCTION; OXIDATIVE STRESS; METABOLIC SYNDROME;
   CARDIOVASCULAR-DISEASE; DIABETES-MELLITUS; FOLLOW-UP; IN-VIVO;
   RESISTANCE; SENSITIVITY; ACTIVATION
AB Metformin improves insulin's action on whole-body glucose metabolism in various insulin-resistant populations. The detailed cellular mechanism(s) for its metabolic actions are multiple and still incompletely understood. Beyond metabolic actions, metformin also impacts microvascular function. However, the effects of metformin on microvascular function and microvascular insulin action specifically are poorly defined. In this mini-review, we summarize what is currently known about metformin's beneficial impact on both microvascular function and the microvascular response to insulin while highlighting methodologic issues in the literature that limit straightforward mechanistic understanding of these effects. We examine potential mechanisms for these effects based on pharmacologically dosed studies and propose that metformin may improve human microvascular insulin resistance by attenuating oxidative stress, inflammation, and endothelial dysfunction. Finally, we explore several important evidence gaps and discuss avenues for future investigation that may clarify whether metformin's ability to improve microvascular insulin sensitivity is linked to its positive impact on vascular outcomes.
C1 [Love, Kaitlin M.; Barrett, Eugene J.; Horton, William B.] Univ Virginia, Dept Med, Div Endocrinol & Metab, Sch Med, Charlottesville, VA 22903 USA.
   [Barrett, Eugene J.] Univ Virginia, Dept Pharmacol, Sch Med, Charlottesville, VA 22903 USA.
C3 University of Virginia; University of Virginia
RP Horton, WB (corresponding author), UVA Endocrinol, 1335 Lee St, Charlottesville, VA 22903 USA.
EM WBH2N@uvahealth.org
OI Love, Kaitlin/0000-0002-9352-393X
FU National Center for Advancing Translational Sciences of the National
   Institutes of Health [KL2TR003016/ULTR003015]; National Heart, Lung, and
   Blood Institute of the National Institutes of Health [R01HL142250];
   American Heart Association [941481]; National Heart Lung and Blood
   Institute [R01HL142250] Funding Source: NIH RePORTER; American Heart
   Association (AHA) [941481] Funding Source: American Heart Association
   (AHA)
FX K.L.M. was supported in part by the National Center for Advancing
   Translational Sciences of the National Institutes of Health under Award
   Numbers KL2TR003016/ULTR003015. E.J.B. was supported by the National
   Heart, Lung, and Blood Institute of the National Institutes of Health
   under Award Number R01HL142250. W.B.H. was supported by the American
   Heart Association under Award Number 941481. The content is solely the
   responsibility of the authors and does not necessarily represent the
   official views of either the National Institutes of Health or the
   American Heart Association.
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NR 70
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Z9 6
U1 0
U2 6
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0013-7227
EI 1945-7170
J9 ENDOCRINOLOGY
JI Endocrinology
PD OCT 11
PY 2022
VL 163
IS 11
AR bqac162
DI 10.1210/endocr/bqac162
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 5K0CM
UT WOS:000869402700005
PM 36201598
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Kytikova, OY
   Novgorodtseva, TP
   Antonyuk, MV
   Gvozdenko, TA
AF Kytikova, O. Yu.
   Novgorodtseva, T. P.
   Antonyuk, M. V.
   Gvozdenko, T. A.
TI Plasmalogens in the Pathophysiology and Therapy of Age-Specific Diseases
SO ADVANCES IN GERONTOLOGY
LA English
DT Article
DE plasmalogens; aging; neurodegenerative diseases; metabolic diseases
ID PARKINSONS-DISEASE; ALZHEIMERS-DISEASE; COGNITIVE IMPAIRMENT;
   LIPID-COMPOSITION; CHOLINE; HEALTH; ACID; BIOMARKERS; BRAIN
AB The pathogenesis of age-related diseases such as metabolic syndrome, type-2 diabetes, Parkinson's disease, and Alzheimer's disease is associated with oxidative stress and chronic inflammation. Impairment of redox homeostasis is accompanied by the development of peroxisome dysfunction and impaired biosynthesis of plasmalogens, which may be associated with aging and the development of age-dependent pathology. Plasmalogens, which reflect the functional activity of peroxisomes, can serve not only as potential biomarkers of diseases associated with oxidative stress and aging but also as an important therapeutic target. The purpose of this review was to analyze the current knowledge of understudied biological and pathological aspects of plasmalogen participation in the pathophysiology of neurodegenerative and metabolic diseases of older persons. An understanding of the role of plasmalogens in the pathophysiology of these diseases can lead to the development of effective diagnostic and prognostic biomarkers, as well as treatment methods for neurodegenerative and metabolic diseases of older people.
C1 [Kytikova, O. Yu.; Novgorodtseva, T. P.; Antonyuk, M. V.; Gvozdenko, T. A.] Res Inst Med Climatol & Rehabil Treatment, Vladivostok Branch, Far Eastern Sci Ctr Physiol & Pathol Respirat, Vladivostok 690105, Russia.
RP Kytikova, OY (corresponding author), Res Inst Med Climatol & Rehabil Treatment, Vladivostok Branch, Far Eastern Sci Ctr Physiol & Pathol Respirat, Vladivostok 690105, Russia.
EM kytikova@yandex.ru
RI kytikova, oxana/JCD-9123-2023; Antonyuk, Marina/I-4862-2016; Gvozdenko,
   Tatyana/I-6374-2016; Novgorodtseva, Tatyana/E-9441-2016
OI Gvozdenko, Tatyana/0000-0002-6413-9840; Novgorodtseva,
   Tatyana/0000-0002-6058-201X
FU federal budget as part of the state assignment of the Federal Research
   Institute
FX The study was financially supported by the federal budget as part of the
   state assignment of the Federal Research Institute.
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NR 70
TC 3
Z9 3
U1 0
U2 9
PU PLEIADES PUBLISHING INC
PI NEW YORK
PA PLEIADES HOUSE, 7 W 54 ST, NEW YORK,  NY, UNITED STATES
SN 2079-0570
EI 2079-0589
J9 ADV GERONTOL
JI Adv. Gerontol.
PD JUL
PY 2020
VL 10
IS 3
BP 272
EP 281
DI 10.1134/S207905702003011X
PG 10
WC Geriatrics & Gerontology
WE Emerging Sources Citation Index (ESCI)
SC Geriatrics & Gerontology
GA NR8ID
UT WOS:000571802700013
DA 2025-06-11
ER

PT J
AU Lova, RM
   Vassalle, C
   Masini, E
   Del Ry, S
   Cabiati, M
   Pasquini, G
   Macchi, C
AF Lova, Raffaello Molino
   Vassalle, Cristina
   Masini, Elisabetta
   Del Ry, Silvia
   Cabiati, Manuela
   Pasquini, Guido
   Macchi, Claudio
TI Relationship between inflammatory parameters and cardiovascular and
   lifestyle factors in the Mugello study oldest old
SO BIOMARKERS IN MEDICINE
LA English
DT Article
DE cardiovascular risk factors; inflammation; lifestyle; nonagenarians;
   oldest old; oxidative stress
ID CORONARY-ARTERY-DISEASE; METABOLIC SYNDROME; OXIDATIVE STRESS;
   URIC-ACID; PHYSICAL FUNCTION; BLOOD; LONGEVITY; VOLUME; RISK; AGE
AB Aim: To explore possible inter-relationships of various biomarkers of inflammation and lifestyle and other cardiovascular risk factors (age, gender, smoking history, hypertension, Type 2 diabetes, dyslipidemia, alteration of circadian rhythms, body mass index, calf circumference, thigh circumference, abdominal circumference) in the Mugello study oldest old. Methods: In 399 noninstitutionalized nonagenarians (291 women), whole blood cells, mean platelet volume, C-reactive protein, uric acid, gamma-glutamyl transferase were assessed. Results: Aging resulted as the only independent determinant for uric acid (<0.05), and abdominal circumference for C-reactive protein. Female gender (<0.01), and thigh circumference (<0.05) remained as determinants for mean platelet volume, age (<0.01), and male gender (<0.01) for gamma-glutamyl transferase, and Type 2 diabetes (<= 0.01) and alteration of circadian rhythms (<0.05) for whole blood cells. Conclusion: Several inflammatory parameters remain associated with adverse lifestyle and cardiovascular risk factors even among nonagenarians.
   [GRAPHICS]
   .
C1 [Lova, Raffaello Molino; Masini, Elisabetta; Pasquini, Guido; Macchi, Claudio] Fdn Don C Gnocchi, IRCCS, Florence, Italy.
   [Vassalle, Cristina] Fdn CNR Reg Toscana G Monasterio, Pisa, Italy.
   [Del Ry, Silvia; Cabiati, Manuela] Italian Natl Res Council, Ist Fisiol Clin, Pisa, Italy.
C3 IRCCS Fondazione Don Carlo Gnocchi Onlus; Consiglio Nazionale delle
   Ricerche (CNR)
RP Vassalle, C (corresponding author), Fdn CNR Reg Toscana G Monasterio, Pisa, Italy.
EM cristina.vassalle@ftgm.it
RI Del Ry, Silvia/C-1149-2015; Pasquini, Guido/J-2620-2018; Cabiati,
   Manuela/K-1306-2014
OI Pasquini, Guido/0000-0002-1811-102X; Cabiati,
   Manuela/0000-0002-0811-6257; MACCHI, Claudio/0000-0003-2265-3216
CR ADAMOPOULOS D, 1977, ACTA ENDOCRINOL-COP, V85, P198
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NR 40
TC 1
Z9 1
U1 0
U2 10
PU FUTURE MEDICINE LTD
PI LONDON
PA UNITEC HOUSE, 3RD FLOOR, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON, N3
   1QB, ENGLAND
SN 1752-0363
EI 1752-0371
J9 BIOMARK MED
JI Biomark. Med.
PD OCT
PY 2018
VL 12
IS 10
BP 1115
EP 1124
DI 10.2217/bmm-2017-0441
PG 10
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Research & Experimental Medicine
GA GW4HH
UT WOS:000446872600007
PM 30203672
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Litwin, M
   Feber, J
   Niemirska, A
   Michalkiewicz, J
AF Litwin, Mieczyslaw
   Feber, Janusz
   Niemirska, Anna
   Michalkiewicz, Jacek
TI Primary hypertension is a disease of premature vascular aging associated
   with neuro-immuno-metabolic abnormalities
SO PEDIATRIC NEPHROLOGY
LA English
DT Review
DE Primary hypertension; Children; Immunologic activity; Sympathetic
   activity; Metabolic syndrome; Target organ damage; Vascular aging
ID RENIN-ANGIOTENSIN SYSTEM; LEFT-VENTRICULAR MASS; BLOOD-PRESSURE;
   OXIDATIVE STRESS; INSULIN-RESISTANCE; BETA-BLOCKERS; CARDIORESPIRATORY
   FITNESS; CARDIOVASCULAR MORBIDITY; PSYCHOSOCIAL STRESS; RECEPTOR
   BLOCKERS
AB There is an increasing amount of data indicating that primary hypertension (PH) is not only a hemodynamic phenomenon but also a complex syndrome involving abnormal fat tissue distribution, over-activity of the sympathetic nervous system (SNS), metabolic abnormalities, and activation of the immune system. In children, PH usually presents with a typical phenotype of disturbed body composition, accelerated biological maturity, and subtle immunological and metabolic abnormalities. This stage of the disease is potentially reversible. However, long-lasting over-activity of the SNS and immuno-metabolic alterations usually lead to an irreversible stage of cardiovascular disease. We describe an intermediate phenotype of children with PH, showing that PH is associated with accelerated development, i.e., early premature aging of the immune, metabolic, and vascular systems. The associations and determinants of hypertensive organ damage, the principles of treatment, and the possibility of rejuvenation of the cardiovascular system are discussed.
C1 [Litwin, Mieczyslaw; Niemirska, Anna] Childrens Mem Hlth Inst, Dept Nephrol & Arterial Hypertens, Warsaw, Poland.
   [Feber, Janusz] Univ Ottawa, Childrens Hosp Eastern Ontario, Dept Pediat, Ottawa, ON, Canada.
   [Michalkiewicz, Jacek] Childrens Mem Hlth Inst, Dept Microbiol & Immunol, Warsaw, Poland.
   [Michalkiewicz, Jacek] Med Univ, Dept Immunol, Bydgoszcz, Poland.
C3 Children's Memorial Health Institute; University of Ottawa; Children's
   Hospital of Eastern Ontario; Children's Memorial Health Institute;
   Nicolaus Copernicus University
RP Litwin, M (corresponding author), Childrens Mem Hlth Inst, Dept Nephrol & Arterial Hypertens, Warsaw, Poland.
EM m.litwin@ipczd.pl
RI Michałkiewicz, Jacek/I-1135-2014; Feber, Janusz/LTD-8835-2024; Litwin,
   Mieczyslaw/L-4648-2017; Niemirska, Anna/W-2780-2018
OI Litwin, Mieczyslaw/0000-0002-5241-2483; Niemirska,
   Anna/0000-0003-4546-5541; Michalkiewicz, Jacek/0000-0001-7773-1766
FU National Research Centre [2013/11/B/NZ4/03832]
FX We wish to thank Mrs. Brandy Brookings for her linguistic revision of
   the manuscript. The authors were supported by grant of National Research
   Centre 2013/11/B/NZ4/03832
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NR 101
TC 30
Z9 34
U1 0
U2 22
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0931-041X
EI 1432-198X
J9 PEDIATR NEPHROL
JI Pediatr. Nephrol.
PD FEB
PY 2016
VL 31
IS 2
BP 185
EP 194
DI 10.1007/s00467-015-3065-y
PG 10
WC Pediatrics; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics; Urology & Nephrology
GA CZ9ZZ
UT WOS:000367457800003
PM 25724169
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Carallo, C
   Fortunato, L
   de Franceschi, MS
   Irace, C
   Tripolino, C
   Cristofaro, MG
   Giudice, M
   Gnasso, A
AF Carallo, Claudio
   Fortunato, Leonzio
   de Franceschi, Maria Serena
   Irace, Concetta
   Tripolino, Cesare
   Cristofaro, Maria Giulia
   Giudice, Mario
   Gnasso, Agostino
TI Periodontal disease and carotid atherosclerosis: Are hemodynamic forces
   a link?
SO ATHEROSCLEROSIS
LA English
DT Article
DE Shear stress; Carotid atherosclerosis; Periodontal disease
ID WALL SHEAR-STRESS; INTIMA-MEDIA THICKNESS; METABOLIC SYNDROME; ARTERY
   PLAQUE; TOOTH LOSS; RISK; INFLAMMATION; INFECTIONS; ASSOCIATION;
   POPULATION
AB Objective: The link between periodontal disease and atherosclerosis has not yet been clarified, though systemic inflammation seems to be the common soil for both conditions. Inflammation influences also hemodynamic forces, that act as local risk factors for carotid plaques. It is not known if the link between periodontitis and carotid atherosclerosis is mediated, at least in part, by physical forces. Therefore, aim of the present study was to evaluate the association between carotid shear stress force and periodontal disease.
   Methods: Thirty-three subjects underwent complete cardiovascular screening, carotid hemodynamic evaluation and dental inspection. Presence of classical risk factors for atherosclerosis, common carotid peak and mean wall shear stress values and periodontal indices of disease (plaque index, gingival index and pocket deep) have been evaluated.
   Results: Worse periodontal health was associated to the presence of carotid atherosclerosis. Patients with carotid plaques (n = 19) had higher periodontal indices compared with subjects without plaques (n = 14) (gingival index: 1.40 +/- 0.71 vs. 0.69 +/- 0.64, p = 0.006). These relations were independent of the presence of cardiovascular risk factors in multiple logistic regression analysis. In the 66 examined common carotids, wall shear stress was inversely related to all periodontal indices (r = 0.54, p < 0.00001 for peak wall shear stress and gingival index). These relations remained significant also in multiple regression analysis, after correction for cardiovascular risk factors, gender and age.
   Conclusions: The present study identifies for the first time a link between periodontal indices and wall shear stress, suggesting that an alteration of hemodynamic profile might contribute to atherosclerosis in subjects with periodontal disease. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
C1 [Carallo, Claudio; de Franceschi, Maria Serena; Irace, Concetta; Tripolino, Cesare; Gnasso, Agostino] Magna Graecia Univ Catanzaro, Dept Clin & Expt Med G Salvatore, Metab Dis Unit, I-88100 Catanzaro, Italy.
   [Fortunato, Leonzio; de Franceschi, Maria Serena] Magna Graecia Univ Catanzaro, Inst Dent, I-88100 Catanzaro, Italy.
   [Cristofaro, Maria Giulia; Giudice, Mario] Magna Graecia Univ Catanzaro, Inst Oral & Maxillofacial Surg, I-88100 Catanzaro, Italy.
C3 Magna Graecia University of Catanzaro; Magna Graecia University of
   Catanzaro; Magna Graecia University of Catanzaro
RP Carallo, C (corresponding author), Magna Graecia Univ Catanzaro, Dept Clin & Expt Med G Salvatore, Metab Dis Unit, Viale Europa, I-88100 Catanzaro, Italy.
EM numemaca@yahoo.it
RI Irace, Concetta/AAC-7796-2022; GIUDICE, Mario/AAH-9363-2020; Cristofaro,
   Maria/AAP-3759-2020
OI Fortunato, leonzio/0000-0001-8701-5018; Carallo,
   Claudio/0000-0002-3958-3245; CRISTOFARO, Maria
   Giulia/0000-0002-6365-8518; GIUDICE, Mario/0000-0001-9374-0566; IRACE,
   Concetta/0000-0001-5182-5473
CR [Anonymous], 1964, ACTA ODONTOL SCAND, DOI DOI 10.3109/00016356408993968
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NR 31
TC 14
Z9 17
U1 0
U2 10
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0021-9150
J9 ATHEROSCLEROSIS
JI Atherosclerosis
PD NOV
PY 2010
VL 213
IS 1
BP 263
EP 267
DI 10.1016/j.atherosclerosis.2010.07.025
PG 5
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 669NB
UT WOS:000283356400090
PM 20732683
DA 2025-06-11
ER

PT J
AU Mosca, A
   Abreu, ATAY
   Gwee, KA
   Ianiro, G
   Tack, J
   Nguyen, TVH
   Hill, C
AF Mosca, Alexis
   Abreu, Ana Teresa Abreu Y.
   Gwee, Kok Ann
   Ianiro, Gianluca
   Tack, Jan
   Thi Viet Ha Nguyen
   Hill, Colin
TI The clinical evidence for postbiotics as microbial therapeutics
SO GUT MICROBES
LA English
DT Review
DE Microbiota; postbiotics; microbial therapeutics; clinical benefits;
   gastrointestinal disorders; allergy; upper respiratory tract infection;
   stress; metabolic syndrome
ID IRRITABLE-BOWEL-SYNDROME; LACTOBACILLUS-ACIDOPHILUS LB; PERENNIAL
   ALLERGIC RHINITIS; BIFIDOBACTERIUM-LONGUM; DOUBLE-BLIND; GUT MICROBIOTA;
   ACUTE DIARRHEA; BRAIN; MULTICENTER; STRESS
AB An optimally operating microbiome supports protective, metabolic, and immune functions, but disruptions produce metabolites and toxins which can be involved in many conditions. Probiotics have the potential to manage these. However, their use in vulnerable people is linked to possible safety concerns and maintaining their viability is difficult. Interest in postbiotics is therefore increasing. Postbiotics contain inactivated microbial cells or cell components, thus are more stable and exert similar health benefits to probiotics. To review the evidence for the clinical benefits of postbiotics in highly prevalent conditions and consider future potential areas of benefit. There is growing evidence revealing the diverse clinical benefits of postbiotics in many prevalent conditions. Postbiotics could offer a novel therapeutic approach and may be a safer alternative to probiotics. Establishing interaction mechanisms between postbiotics and commensal microorganisms will improve the understanding of potential clinical benefits and may lead to targeted postbiotic therapy.
C1 [Mosca, Alexis] APHP Robert Debre, Pediat Gastroenterol & Nutr Dept, Paris, France.
   [Abreu, Ana Teresa Abreu Y.] Angeles Pedregal Hosp, Mexico City, DF, Mexico.
   [Gwee, Kok Ann] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Med, Singapore, Singapore.
   [Gwee, Kok Ann] Gleneagles Hosp, Singapore, Singapore.
   [Ianiro, Gianluca] Fdn Policlin Univ A Gemelli IRCCS, Gastroenterol Unit, Rome, Italy.
   [Tack, Jan] Univ Hosp Leuven, Dept Gastroenterol, Leuven, Belgium.
   [Thi Viet Ha Nguyen] Natl Childrens Hosp, Dept Gastroenterol, Hanoi, Vietnam.
   [Hill, Colin] Univ Coll Cork, APC Microbiome Inst, Cork, Ireland.
C3 Assistance Publique Hopitaux Paris (APHP); Universite Paris Cite;
   Hopital Universitaire Robert-Debre - APHP; National University of
   Singapore; Catholic University of the Sacred Heart; IRCCS Policlinico
   Gemelli; KU Leuven; University Hospital Leuven; University College Cork
RP Hill, C (corresponding author), Univ Coll Cork, APC Microbiome Inst, Cork, Ireland.
EM c.hill@ucc.ie
RI Mosca, Antonella/H-5381-2016; Abreu, Ana/KSL-7277-2024; Hill,
   Colin/A-5611-2012; Ianiro, Gianluca/K-5578-2016
OI Hill, Colin/0000-0002-8527-1445; Ianiro, Gianluca/0000-0002-8318-0515;
   Tack, Jan/0000-0002-3206-6704; mosca, alexis/0000-0001-9504-5516; Gwee,
   Kok Ann/0000-0002-4813-0053
FU ADARE
FX This expert review was sponsored by an independent grant from ADARE.
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NR 101
TC 58
Z9 62
U1 9
U2 120
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1949-0976
EI 1949-0984
J9 GUT MICROBES
JI Gut Microbes
PD DEC 31
PY 2022
VL 14
IS 1
AR 2117508
DI 10.1080/19490976.2022.2117508
PG 14
WC Gastroenterology & Hepatology; Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Microbiology
GA 5A6WF
UT WOS:000863025100001
PM 36184735
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Martínez-Ballesta, MC
   Dominguez-Perles, R
   Moreno, DA
   Muries, B
   Alcaraz-López, C
   Bastías, E
   García-Viguera, C
   Carvajal, M
AF Martinez-Ballesta, M. C.
   Dominguez-Perles, R.
   Moreno, D. A.
   Muries, B.
   Alcaraz-Lopez, C.
   Bastias, E.
   Garcia-Viguera, C.
   Carvajal, M.
TI Minerals in plant food: effect of agricultural practices and role in
   human health. A review
SO AGRONOMY FOR SUSTAINABLE DEVELOPMENT
LA English
DT Review
DE environmental stress; human health; mineral fertilisation; mineral
   nutrition
ID KOHLRABI BRASSICA-OLERACEA; BLOSSOM-END ROT; SOIL FERTILITY; SULFUR
   FERTILIZATION; NUTRITIONAL QUALITY; FRUIT-QUALITY; MICRONUTRIENT
   NUTRITION; NITRATE ACCUMULATION; METABOLIC SYNDROME; DIETARY MAGNESIUM
AB Interest in nutrient absorption and accumulation is derived from the need to increase crop productivity by better nutrition and also to improve the nutritional quality of plants as foods and feeds. This review focuses on contrasting data on the importance for human health of food mineral nutrients (Ca, Mg, K, Na and P) and also the trace elements considered essential or beneficial for human health (Cr, Co, Cu, Fe, Mn, Mo, Ni, Se and Zn). In addition, environmental stresses such as salinity, drought, extreme temperatures and light conditions that affect mineral content were revised in the light that the effect of these factors depends on the species or cultivar, and the specific plant organ, as well as the intensity and duration of the stress. Differences between inorganic and organic fertilisation practices on the mineral levels were also analysed to evaluate the influence of external factors on the quality of plant-based foods.
C1 [Martinez-Ballesta, M. C.; Muries, B.; Alcaraz-Lopez, C.; Carvajal, M.] CSIC, Plant Nutr Dept, CEBAS, Murcia 30100, Spain.
   [Dominguez-Perles, R.; Moreno, D. A.; Garcia-Viguera, C.] CSIC, CEBAS, Food Sci & Technol Dept, Murcia 30100, Spain.
   [Bastias, E.] Univ Tarapaca, Dept Agr Prod, Fac Ciencias Agron, Arica, Chile.
C3 Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Centro de
   Edafologia y Biologia Aplicada del Segura (CEBAS); Consejo Superior de
   Investigaciones Cientificas (CSIC); CSIC - Centro de Edafologia y
   Biologia Aplicada del Segura (CEBAS); Universidad de Tarapaca
RP Carvajal, M (corresponding author), CSIC, Plant Nutr Dept, CEBAS, POB 164, Murcia 30100, Spain.
EM mcarvaja@cebas.csic.es
RI GARCIA-VIGUERA, CRISTINA/B-2153-2012; Dominguez-Perles,
   Raul/J-7456-2013; Martinez Ballesta, MCarmen/C-2190-2009;
   Moreno-Fernandez, Diego Angel/G-4379-2011; Carvajal, Micaela/H-8920-2015
OI GARCIA-VIGUERA, CRISTINA/0000-0002-4751-3917; Dominguez-Perles,
   Raul/0000-0001-6232-712X; Martinez Ballesta,
   MCarmen/0000-0002-4372-5525; Moreno-Fernandez, Diego
   Angel/0000-0002-6547-8764; Bastias, Elizabeth/0009-0006-0675-1181;
   Carvajal, Micaela/0000-0001-7321-4956
FU CICYT [AGL2006-06499]; Fundacion Seneca-Comunidad Autonoma de la Region
   de Murcia [08753/PI/08]; Convenio de Desempeno-UTA-MECESUP2
   (Arica-Chile); Fundacion Seneca [09769/IV2/08]
FX This work was funded by the CICYT (AGL2006-06499) and the Fundacion
   Seneca-Comunidad Autonoma de la Region de Murcia (08753/PI/08). This
   work was funded partly by a Convenio de Desempeno-UTA-MECESUP2
   (Arica-Chile). E. Bast as received a fellowship from the Fundacion
   Seneca, 09769/IV2/08.
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NR 151
TC 160
Z9 178
U1 8
U2 163
PU SPRINGER FRANCE
PI PARIS
PA 22 RUE DE PALESTRO, PARIS, 75002, FRANCE
SN 1774-0746
EI 1773-0155
J9 AGRON SUSTAIN DEV
JI Agron. Sustain. Dev.
PD APR-JUN
PY 2010
VL 30
IS 2
BP 295
EP 309
DI 10.1051/agro/2009022
PG 15
WC Agronomy; Green & Sustainable Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture; Science & Technology - Other Topics
GA 584RI
UT WOS:000276769800007
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Motavalli, R
   Majidi, T
   Pourlak, T
   Abediazar, S
   Shoja, MM
   Vahed, SZ
   Etemadi, J
AF Motavalli, Roza
   Majidi, Taraneh
   Pourlak, Tala
   Abediazar, Sima
   Shoja, Mohammadali M.
   Vahed, Sepideh Zununi
   Etemadi, Jalal
TI The clinical significance of the glucocorticoid receptors: Genetics and
   epigenetics
SO JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
LA English
DT Review
DE Glucocorticoid receptor; Steroid-resistance; Methylation
ID PITUITARY-ADRENAL AXIS; BODY-MASS INDEX; NR3C1 GENE; ER22/23EK
   POLYMORPHISM; N363S POLYMORPHISM; METABOLIC SYNDROME; BCLI POLYMORPHISM;
   EATING-DISORDERS; TURKISH PATIENTS; RISK-FACTORS
AB The impacts of glucocorticoids (GCs) are mainly mediated by a nuclear receptor (GR) existing in almost every tissue. The GR regulates a wide range of physiological functions, including inflammation, cell metabolism, and differentiation playing a major role in cellular responses to GCs and stress. Therefore, the dysregulation or disruption of GR can cause deficiencies in the adaptation to stress and the preservation of homeostasis. The number of GR polymorphisms associated with different diseases has been mounting per year. Tackling these clinical complications obliges a comprehensive understanding of the molecular network action of GCs at the level of the GR structure and its signaling pathways. Beyond genetic variation in the GR gene, epigenetic changes can enhance our understanding of causal factors involved in the development of diseases and identifying biomarkers. In this review, we highlight the relationships of GC receptor gene polymorphisms and epigenetics with different diseases.
C1 [Motavalli, Roza; Majidi, Taraneh; Abediazar, Sima; Vahed, Sepideh Zununi; Etemadi, Jalal] Tabriz Univ Med Sci, Kidney Res Ctr, Tabriz, Iran.
   [Pourlak, Tala] Tabriz Univ Med Sci, Dept Pathol, Tabriz, Iran.
   [Shoja, Mohammadali M.] Ross Univ, Clin Acad Teaching & Learning, Sch Med, Miramar, FL USA.
C3 Tabriz University of Medical Science; Tabriz University of Medical
   Science
RP Vahed, SZ; Etemadi, J (corresponding author), Tabriz Univ Med Sci, Kidney Res Ctr, Tabriz, Iran.
EM zununivahed@tbzmed.ac.ir; etemadij@tbzmed.ac.ir
RI Etemadi, Jalal/M-9167-2017; Shoja, Mohammadali/ABH-1563-2020; abediazar,
   sima/AAM-5949-2021; Majidi, Taraneh/KHY-7374-2024; Zununi Vahed,
   Sepideh/W-2737-2017
OI Pourlak, Tala/0009-0004-2575-6936; Zununi Vahed,
   Sepideh/0000-0003-0179-4562
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NR 159
TC 25
Z9 26
U1 0
U2 22
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0960-0760
EI 1879-1220
J9 J STEROID BIOCHEM
JI J. Steroid Biochem. Mol. Biol.
PD OCT
PY 2021
VL 213
AR 105952
DI 10.1016/j.jsbmb.2021.105952
EA JUL 2021
PG 13
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA WC1FF
UT WOS:000704009000004
PM 34274458
DA 2025-06-11
ER

PT J
AU Rodríguez-Pérez, C
   Segura-Carretero, A
   Contreras, MD
AF Rodriguez-Perez, Celia
   Segura-Carretero, Antonio
   del Mar Contreras, Maria
TI Phenolic compounds as natural and multifunctional anti-obesity agents: A
   review
SO CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
LA English
DT Review
DE Obesity; metabolic syndrome; phenolic compounds; natural products;
   clinical trials
ID GREEN TEA EXTRACT; BROWN ADIPOSE-TISSUE; FRAXINUS-EXCELSIOR L.;
   DIET-INDUCED OBESITY; FATTY-ACID SYNTHASE; DOUBLE-BLIND; WEIGHT-LOSS;
   CARDIOVASCULAR-DISEASE; INSULIN-RESISTANCE; OXIDATIVE STRESS
AB Prevalence of obesity worldwide has reached pandemic proportions. Despite the increasing evidence in the implication of phenolic compounds in obesity management, the real effect is not completely understood. The available in vitro and in vivo studies have demonstrated the implication of phenolic compounds in: lowering food intake, decreasing lipogenesis, increasing lipolysis, stimulating fatty acids beta-oxidation, inhibiting adipocyte differentiation and growth, attenuating inflammatory responses and suppress oxidative stress. This review encompasses the most recent evidence in the anti-obesity effect of phenolic compounds from plants to different nutraceuticals and functional foods based on the in vitro, in vivo and clinical studies. For that, this review has been focused on popular plant-based products highly consumed today such as cocoa, cinnamon, and olive oil, beverages such as red wine, tea (green, white and black tea) and Hibiscus sabdariffa L. tea, among others.
C1 [Rodriguez-Perez, Celia; Segura-Carretero, Antonio] Univ Granada, Dept Analyt Chem, Fac Sci, Ave Fuentenueva S-N, E-18071 Granada, Spain.
   [del Mar Contreras, Maria] Univ Cordoba, Dept Analyt Chem, Annex C-3 Bldg,Campus Rabanales, Cordoba, Spain.
C3 University of Granada; Universidad de Cordoba
RP Rodríguez-Pérez, C (corresponding author), Univ Granada, Dept Analyt Chem, Fac Sci, Ave Fuentenueva S-N, E-18071 Granada, Spain.
EM celiarp@ugr.es
RI Rodríguez-Pérez, Celia/R-7378-2019; del Mar Contreras,
   María/K-9122-2014; segura Carretero, Antonio/B-6867-2014
OI Rodriguez-Perez, Celia/0000-0002-7233-6481; segura Carretero,
   Antonio/0000-0002-5564-5338; CONTRERAS, MARIA DEL
   MAR/0000-0002-3407-0088
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NR 144
TC 128
Z9 133
U1 6
U2 81
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1040-8398
EI 1549-7852
J9 CRIT REV FOOD SCI
JI Crit. Rev. Food Sci. Nutr.
PD APR 28
PY 2019
VL 59
IS 8
BP 1212
EP 1229
DI 10.1080/10408398.2017.1399859
PG 18
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA HY4AG
UT WOS:000468068600002
PM 29156939
DA 2025-06-11
ER

PT J
AU Puchau, B
   Ochoa, MC
   Zulet, MA
   Marti, A
   Martínez, JA
AF Puchau, Blanca
   Ochoa, Maria C.
   Angeles Zulet, Ma
   Marti, Amelia
   Alfredo Martinez, J.
CA Genoi Members
TI Dietary total antioxidant capacity and obesity in children and
   adolescents
SO INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION
LA English
DT Article
DE Total antioxidant capacity; oxidative stress; childhood obesity;
   food-frequency questionnaire; diet; body weight homeostasis
ID FOOD-FREQUENCY QUESTIONNAIRE; SPECIES ROS GENERATION; IN-VITRO ASSAYS;
   METABOLIC SYNDROME; INSULIN-RESISTANCE; CHILDHOOD OBESITY; OXIDATIVE
   STRESS; PLASMA; LEUKOCYTES; ADULTS
AB Background Dietary antioxidant intake has been suggested to protect against oxidative damage and related clinical complications. The aim of the present study was to assess the potential relationships between the dietary total antioxidant capacity (TAC) and obesity-related features in children and adolescents.
   Materials and methods Anthropometric variables from 369 children and adolescents were measured (184 obese and 185 control). A validated food-frequency questionnaire was used to calculate the TAC and the daily nutrient and energy intake.
   Results Dietary TAC showed positive associations with fiber, folic acid, magnesium, and vitamins A, C and E. The body mass index, standard deviation score of body mass index and total body fat were inversely associated with dietary TAC only in obese subjects.
   Conclusion These data suggest that dietary TAC may be a potential indicator of the risk to develop obesity-related features and could be considered a useful method in assessing antioxidant intake.
C1 [Puchau, Blanca; Ochoa, Maria C.; Angeles Zulet, Ma; Marti, Amelia; Alfredo Martinez, J.; Genoi Members] Univ Navarra, Dept Nutr & Food Sci, Pamplona 31008, Spain.
C3 University of Navarra
RP Martínez, JA (corresponding author), Univ Navarra, Dept Nutr & Food Sci, Irunlarrea 1, Pamplona 31008, Spain.
EM jalfmtz@unav.es
RI Marti del Moral, Amelia/H-1192-2017; Ochoa, Maria Carmen/K-4508-2017;
   Zulet, M. Angeles/H-1317-2017; Martinez Hernandez, J Alfredo/K-8709-2014
OI Marti del Moral, Amelia/0000-0001-9832-7981; Ochoa, Maria
   Carmen/0000-0001-9920-2144; Zulet, M. Angeles/0000-0002-3926-0892;
   Martinez Hernandez, J Alfredo/0000-0001-5218-6941
FU Ibercaja, CIBERobn, which is an initiative of the ISC-III
   [CB06/03/1017]; Linea Especial about Nutrition, Obesity and Health
   (University of Navarra) [LE/97]; University of Navarra
FX The present work has been supported by Ibercaja, CIBERobn, which is an
   initiative of the ISC-III (CB06/03/1017), the Linea Especial about
   Nutrition, Obesity and Health (University of Navarra LE/97) and the
   Asociacion de Amigos fellowships scheme of the University of Navarra.
   The authors report no conflicts of interest. The authors alone are
   responsible for the content and writing of the paper.
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NR 35
TC 49
Z9 52
U1 0
U2 14
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 0963-7486
J9 INT J FOOD SCI NUTR
JI Int. J. Food Sci. Nutr.
PD NOV
PY 2010
VL 61
IS 7
BP 713
EP 721
DI 10.3109/09637481003757860
PG 9
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA 664MW
UT WOS:000282966500005
PM 20528580
DA 2025-06-11
ER

PT J
AU Luo, RX
   Li, LZ
   Liu, XH
   Yuan, YJ
   Zhu, WZ
   Li, L
   Liu, JP
   Lu, YR
   Cheng, JQ
   Chen, YN
AF Luo, Ruixi
   Li, Linzhao
   Liu, Xiaohong
   Yuan, Yujia
   Zhu, Wuzheng
   Li, Lan
   Liu, Jingping
   Lu, Yanrong
   Cheng, Jingqiu
   Chen, Younan
TI Mesenchymal stem cells alleviate palmitic acid-induced
   endothelial-to-mesenchymal transition by suppressing endoplasmic
   reticulum stress
SO AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
LA English
DT Article
DE cell transplantation; endoplasmic reticulum stress;
   endothelial-tomesenchymal transition; mesenchymal stem cell
ID FATTY-ACIDS; DYSFUNCTION; HYPERGLYCEMIA; LIPOTOXICITY; INFLAMMATION;
   INHIBITION; APOPTOSIS
AB High levels of plasma free fatty acids (FFAs) lead to endothelial dysfunction (ED), which is involved in the pathogenesis of metabolic syndrome, diabetes, and atherosclerosis. Endoplasmic reticulum (ER) stress and endothelial-to-mesenchymal transition (EndMT) are demonstrated to be mechanistically related to endothelial dysfunction. Mesenchymal stem cells (MSCs) have exhibited an extraordinary cytoprotective effect on cellular lipotoxicity and vasculopathy. However, the underlying mechanisms have not been clearly defined. In the present study, we investigated whether MSCs could ameliorate palmitic acid (PA)-induced endothelial lipotoxicity by reducing ER stress and EndMT. We observed that MSC cocultures substantially alleviated PA-induced lipotoxicity in human umbilical vein endothelial cells (HUVECs). MSCs were able to restore the cell viability, increase tubule formation and migration ability, and decrease inflammation response and lipid deposition. Furthermore, PA caused endothelial-to-mesenchymal transition in HUVECs, which was abrogated by MSCs possibly through inhibiting ER stress. In addition, PA stimulated MSCs to secrete more stanniocalcin-1 (STC-1). Knocking down of STC-1 in MSCs attenuated their effects on PA-induced lipotoxicity in HUVECs. In vivo, MSC transplantation alleviated dyslipidemia and endothelial dysfunction in high-fat diet-fed SpragueDawley rats. MSC-treated rats showed reduced expressions of ER stress-related genes in aortas and suppressed expressions of EndMT-related proteins in rat aortic endothelial cells. Overall, our findings indicated that MSCs were able to attenuate endothelial lipotoxicity through inhibiting ER stress and EndMT, in which STC-1 secreted from MSCs may play a critical role.
C1 [Luo, Ruixi; Li, Linzhao; Liu, Xiaohong; Yuan, Yujia; Zhu, Wuzheng; Li, Lan; Liu, Jingping; Lu, Yanrong; Cheng, Jingqiu; Chen, Younan] Sichuan Univ, West China Hosp, Regenerat Med Res Ctr, Key Lab Transplant Engn & Immunol,NHFPC, Chengdu, Peoples R China.
   [Luo, Ruixi] Guizhou Univ Tradit Chinese Med, Stem Cell Therapy Res Ctr, Dept Immunol & Microbiol, Guiyang, Peoples R China.
C3 Sichuan University; Guizhou University of Traditional Chinese Medicine
RP Cheng, JQ; Chen, YN (corresponding author), Sichuan Univ, West China Hosp, Regenerat Med Res Ctr, Key Lab Transplant Engn & Immunol,NHFPC, Chengdu, Peoples R China.
EM jqcheng@scu.edu.cn; chenyounan@scu.edu.cn
RI Yuan, Yu/HTM-9814-2023; Chen, Younan/AAK-1654-2021; Wang,
   Xiaojun/JUU-9683-2023; Liu, Jingping/P-8908-2019
OI Chen, Younan/0000-0002-0455-2473; Ruixi, Luo/0000-0001-9052-1376
FU Program of National Natural Science Foundation of China [81870609,
   31571474, 81571808]; 1.3.5 project for disciplines of excellence, West
   China Hospital, Sichuan University [ZYGD18014]
FX This study was supported by the Program of National Natural Science
   Foundation of China (81870609, 31571474, and 81571808), and the 1.3.5
   project for disciplines of excellence, West China Hospital, Sichuan
   University (ZYGD18014).
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Z9 24
U1 2
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PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0193-1849
EI 1522-1555
J9 AM J PHYSIOL-ENDOC M
JI Am. J. Physiol.-Endocrinol. Metab.
PD DEC
PY 2020
VL 319
IS 6
BP E961
EP E980
DI 10.1152/ajpendo.00155.2020
PG 20
WC Endocrinology & Metabolism; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Physiology
GA OV0PZ
UT WOS:000591924400001
PM 33044844
DA 2025-06-11
ER

PT J
AU Rosa, BV
   Firth, EC
   Blair, HT
   Vickers, MH
   Morel, PCH
   Cockrem, JF
AF Rosa, Brielle V.
   Firth, Elwyn C.
   Blair, Hugh T.
   Vickers, Mark H.
   Morel, Patrick C. H.
   Cockrem, John F.
TI Short-term voluntary exercise in the rat causes bone modeling without
   initiating a physiological stress response
SO AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE
   PHYSIOLOGY
LA English
DT Article
DE computed tomography; corticosterone; exercise; metabolism; stress
ID PITUITARY-ADRENAL AXIS; METABOLIC SYNDROME; PRENATAL STRESS; BIPEDAL
   STANCE; CORTICOSTERONE; SECRETION; PREGNANCY; ESTROGEN; STRENGTH; GROWTH
AB Rosa BV, Firth EC, Blair HT, Vickers MH, Morel PCH, Cockrem JF. Short-term voluntary exercise in the rat causes bone modeling without initiating a physiological stress response. Am J Physiol Regul Integr Comp Physiol 299: R1037-R1043, 2010. First published July 28, 2010; doi:10.1152/ajpregu.00112.2010.-Recent research has revealed a neuroendocrine connection between the skeleton and metabolism. Exercise alters both bone modeling and energy balance and may be useful in further developing our understanding of this complex interplay. However, research in this field requires an animal model of exercise that does not cause a physiological stress response in the exercised subjects. In this study, we develop a model of short-term voluntary exercise in the female rat that causes bone modeling without causing stress. Rats were randomly assigned to one of three age-matched groups: control, tower climbing, and squat exercise (rising to an erect bipedal stance). Exercise for 21 days resulted in bone modeling as assessed by peripheral quantitative computed tomography. Fecal corticosterone output was used to assess physiological stress at three time points during the study (preexercise, early exercise, and late in the exercise period). There were no differences in fecal corticosterone levels between groups or time points. This model of voluntary exercise in the rat will be useful for future studies of the influence of exercise on the relationship between skeletal and metabolic health and may be appropriate for investigation of the developmental origins of those effects.
C1 [Rosa, Brielle V.; Firth, Elwyn C.; Blair, Hugh T.; Cockrem, John F.] Massey Univ, Inst Vet Anim & Biomed Sci, Natl Res Ctr Growth & Dev, Tennent Dr, Palmerston North, New Zealand.
   [Vickers, Mark H.] Massey Univ, Inst Food Nutr & Human Hlth, Palmerston North, New Zealand.
   [Morel, Patrick C. H.] Univ Auckland, Liggins Inst, Auckland 1, New Zealand.
C3 Massey University; Massey University; University of Auckland
RP Rosa, BV (corresponding author), Massey Univ, Inst Vet Anim & Biomed Sci, Natl Res Ctr Growth & Dev, Tennent Dr, Palmerston North, New Zealand.
EM B.V.Rosa@massey.ac.nz
RI Blair, Hugh/C-5569-2014; Cockrem, John/O-9859-2016
OI Cockrem, John/0000-0002-5239-6591; Vickers, Mark/0000-0003-4876-9356
FU National Research Centre for Growth and Development, New Zealand
FX Funding was provided by the National Research Centre for Growth and
   Development, New Zealand.
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NR 65
TC 8
Z9 9
U1 0
U2 3
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0363-6119
EI 1522-1490
J9 AM J PHYSIOL-REG I
JI Am. J. Physiol.-Regul. Integr. Comp. Physiol.
PD OCT
PY 2010
VL 299
IS 4
BP R1037
EP R1043
DI 10.1152/ajpregu.00112.2010
PG 7
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA 674MV
UT WOS:000283751200008
PM 20668232
DA 2025-06-11
ER

PT J
AU Stuver, SO
   Lyons, J
   Coviello, A
   Fredman, L
AF Stuver, Sherri O.
   Lyons, Jennifer
   Coviello, Andrea
   Fredman, Lisa
TI Feasibility of 24-Hr Urine Collection for Measurement of Biomarkers in
   Community-Dwelling Older Adults
SO JOURNAL OF APPLIED GERONTOLOGY
LA English
DT Article
DE biological samples; caregiving; longitudinal study
ID CHRONIC STRESS; CATECHOLAMINE EXCRETION; METABOLIC SYNDROME; DEMENTIA
   PATIENTS; HEALTH; CAREGIVERS; MACARTHUR; NEUROENDOCRINE; MORTALITY;
   SYMPTOMS
AB Biologic markers are becoming a key part of gerontological research, including their measurement at multiple intervals to detect changes over time. This report examined the feasibility and quality of 24-hr urine collection to measure neuroendocrine biomarkers in a community-based sample of older caregivers and non-caregivers. At each interview, participants were instructed on the correct method to collect and store the sample. As incentives, participants selected a day for urine collection within 5 days of the interview, received a reimbursement, and study staff travelled to their home to retrieve the specimen. Between 2008 and 2013, 256 participants were enrolled; all but two participants (99%) provided a baseline urine specimen, of which 93% were considered adequate. Urine collection and quality remained high over three annual follow-up interviews and did not vary by caregiver status or perceived stress level. Our results indicate that 24-hr urine collection is feasible in active, community-dwelling older adults.
C1 [Stuver, Sherri O.; Lyons, Jennifer; Fredman, Lisa] Boston Univ, Sch Publ Hlth, Epidemiol, Boston, MA 02215 USA.
   [Coviello, Andrea] Boston Univ, Sch Med, Boston, MA 02215 USA.
C3 Boston University; Boston University
RP Stuver, SO (corresponding author), Boston Univ, Sch Publ Hlth, Dept Epidemiol, 715 Albany St,Talbot 3 East, Boston, MA 02118 USA.
EM sstuver@bu.edu
FU National Institutes of Health [R01 AG028144, R01 AG18037, UL1 RR025771]
FX The authors disclosed receipt of the following financial support for the
   research, authorship, and/or publication of this article: This study was
   supported by the National Institutes of Health under the following grant
   numbers: R01 AG028144, R01 AG18037, and UL1 RR025771.
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NR 38
TC 10
Z9 10
U1 0
U2 4
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0733-4648
EI 1552-4523
J9 J APPL GERONTOL
JI J. Appl. Gerontol.
PD NOV
PY 2017
VL 36
IS 11
BP 1393
EP 1408
DI 10.1177/0733464815624153
PG 16
WC Gerontology
WE Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA FJ1OF
UT WOS:000412486500008
PM 26759387
DA 2025-06-11
ER

PT J
AU Ozler, S
   Oztas, E
   Erel, O
   Guler, BG
   Ergin, M
   Uygur, D
   Danisman, N
AF Ozler, Sibel
   Oztas, Efser
   Erel, Ozcan
   Guler, Basak Gumus
   Ergin, Merve
   Uygur, Dilek
   Danisman, Nuri
TI Impact of Gestational Diabetes Mellitus and Maternal Obesity on Cord
   Blood Dynamic Thiol/Disulfide Homeostasis
SO FETAL AND PEDIATRIC PATHOLOGY
LA English
DT Article
DE Adverse perinatal outcomes; maternal obesity; gestational diabetes
   mellitus; thiol/disulfide homeostasis
ID OXIDATIVE STRESS; METABOLIC SYNDROME; CHILDHOOD; PLASMA; WOMEN
AB Aim: Our aim in this study was to investigate the effect of maternal obesity and gestational diabetes mellitus (GDM) on cord blood dynamic thiol/disulfide homeostasis. Methods: A prospective case-control study was carried out in 125 pregnant women (27 GDM, 30 obese, 68 controls). Cord blood samples were collected from all participants and native thiol-disulfide exchanges were examined with automated method enabling the measurement of both sides of thiol-disulfide balance. Results: Disulfide amounts, disulfide/native thiol and disulfide/total thiol ratios were increased (p < 0.001), while native thiol/total thiol was decreased in the cord blood of babies born to an obese or diabetic mother (p < 0.001). Moreover, increased disulfide amounts, disulfide/native thiol, disulfide/totalthiol ratios and decreased native/total thiol were found to be significantly associated with adverse outcomes in GDM. Conclusion: The current study suggests that the offsprings born to obese or diabetic mothers are exposed to increased oxidative stress.
C1 [Ozler, Sibel; Oztas, Efser; Uygur, Dilek; Danisman, Nuri] Zekai Tahir BurakWomens Hlth Educ & Res Hosp, Dept Perinatol, Ankara, Turkey.
   [Erel, Ozcan] Yildirim Beyazit Univ, Fac Med, Dept Clin Biochem, Ankara, Turkey.
   [Guler, Basak Gumus] Liv Hosp, Dept Obstet & Gynecol, Ankara, Turkey.
   [Ergin, Merve] Aralik State Hosp, Gaziantep, Turkey.
C3 Dr. Zekai Tahir Burak Women's Health Research & Education Hospital;
   Ankara Yildirim Beyazit University; Ankara Liv Hospital; December 25
   State Hospital
RP Ozler, S (corresponding author), Zekai Tahir Burak Kadin Sagligi EAH, Ankara, Turkey.
EM sibel2ozler@gmail.com
RI Oztas, Efser/ABE-1088-2020; Sahin, Dilek/ABE-3511-2020; Ergin,
   Malik/AGH-2144-2022; EREL, Ozcan/U-1008-2019
OI sahin, Dilek/0000-0001-8567-9048
CR Ates I, 2015, DIABETES RES CLIN PR
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NR 20
TC 9
Z9 9
U1 0
U2 11
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1551-3815
EI 1551-3823
J9 FETAL PEDIATR PATHOL
JI Fetal Pediatr. Pathol.
PY 2017
VL 36
IS 1
BP 8
EP 15
DI 10.1080/15513815.2016.1223237
PG 8
WC Pathology; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pathology; Pediatrics
GA EM2YA
UT WOS:000395180500002
PM 27629439
DA 2025-06-11
ER

PT J
AU Tremblin, G
AF Tremblin, Gerard
TI From land plants to marine diatoms: the scientific journey of a plant
   eco-physiologist
SO DIATOM RESEARCH
LA English
DT Article
DE diatom; macroalga; microalga; stress; photosynthesis; fatty acid
ID CARBONIC-ANHYDRASE ACTIVITY; BLUE-GREEN PIGMENT; HASLEA-OSTREARIA; LIGHT
   QUALITY; SKELETONEMA-COSTATUM; TERM ACCLIMATION; FUCUS-SERRATUS;
   UV-RADIATION; PHOTOSYNTHESIS; GROWTH
AB During my career, mainly I have studied the interaction between environmental factors and the physiology of plants and algae. To cite only the most important, a plant of agronomic interest: Zea mays, then a halophyte: Halopeplis amplexicaulis (Vahl) Ung, brown macroalgae of the genera Fucus and Cystoseira and finally microalgae as Pavlova lutheri, but mostly diatom as Haslea ostrearia and Odontella aurita that have occupied my last 20 years of research at Le Mans University (France). Most of the time, numerous and varied physiological parameters such as growth, photosynthesis by oximetry and modulated fluorometry, metabolic pathways using 14C, enzymatic activities of the major enzymes of carbon fixation and of the antioxidant enzyme system, poly-insaturated fatty acids composition and metabolism in microalgae have been studied in conditions of stress. Currently approaching retirement, I finally conduct experiments with diatoms rich in polyunsaturated fatty acids, supplied as a food supplement to high-fat fed rats having a metabolic syndrome
C1 Univ Maine, PRES LUNAM, MicroMar,UFR Sci & Tech,FR 3473, Inst Univ Mer & Littoral,CNRS,Lab Mer,Sante EA 21, F-72085 Le Mans, France.
C3 Centre National de la Recherche Scientifique (CNRS); CNRS - Institute
   for Engineering & Systems Sciences (INSIS); Le Mans Universite
RP Tremblin, G (corresponding author), Univ Maine, PRES LUNAM, MicroMar,UFR Sci & Tech,FR 3473, Inst Univ Mer & Littoral,CNRS,Lab Mer,Sante EA 21, F-72085 Le Mans, France.
EM tremblin@univ-lemans.fr
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NR 46
TC 1
Z9 1
U1 0
U2 27
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0269-249X
EI 2159-8347
J9 DIATOM RES
JI Diatom Res.
PD JAN 2
PY 2014
VL 29
IS 1
BP 65
EP 73
DI 10.1080/0269249X.2014.880565
PG 9
WC Marine & Freshwater Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Marine & Freshwater Biology
GA AA2OE
UT WOS:000330933100008
DA 2025-06-11
ER

PT J
AU Cort, MA
   Gwebu, ET
   Tull, ES
   Cox, NA
   Modise, T
AF Cort, Malcolm A.
   Gwebu, Ephraim T.
   Tull, Eugene S.
   Cox, Natasha A.
   Modise, Thabiso
TI The differential gender effect of internalized racism on abdominal
   obesity in KwaZulu-Natal, South Africa
SO SOCIAL SCIENCE JOURNAL
LA English
DT Article
DE Internalized racism; South Africa; Type 2 diabetes; Abdominal obesity
ID BODY-FAT DISTRIBUTION; DISEASE RISK-FACTORS; WAIST CIRCUMFERENCE;
   METABOLIC SYNDROME; PERCEIVED RACISM; FASTING GLUCOSE; ASSOCIATION;
   STRESS; WEIGHT; WOMEN
AB This research examined the effect of a psychosocial variable, internalized racism, on abdominal obesity, as measured by waist circumference. Results show that the effect of internalized racism on waist circumference persists net of other controls among women, but not among men. Also, among women who had high levels of internalized racism and high educational levels, a positive relationship to abdominal obesity is evident despite the tendency of education to be protective of abdominal obesity. This study supports other research findings that internalized racism is related to waist circumference among adult women but not among men in Western Hemisphere blacks. It also supports past research findings of a gendered reaction to psychosocial stress. It also illustrates that this relationship occurs on the continent of Africa, an area where research on this phenomenon is scarce. (C) 2013 Western Social Science Association. Published by Elsevier Inc. All rights reserved.
C1 [Cort, Malcolm A.] Athens State Univ, Dept Behav Sci, Athens, AL 35611 USA.
   [Gwebu, Ephraim T.] Elizabeth City State Univ, Dept Chem Geol & Phys, Elizabeth City, NC 27909 USA.
   [Tull, Eugene S.] Univ Pittsburgh, Grad Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA 15260 USA.
   [Cox, Natasha A.] Elizabeth City State Univ, Dept Psychol, Elizabeth City, NC 27909 USA.
   [Modise, Thabiso] Univ Zululand, Dept Sociol, Kwa Dlangezwa, South Africa.
C3 Athens State University; University of North Carolina; Elizabeth City
   State University; Pennsylvania Commonwealth System of Higher Education
   (PCSHE); University of Pittsburgh; University of North Carolina;
   Elizabeth City State University; University of Zululand
RP Cort, MA (corresponding author), Athens State Univ, Dept Behav Sci, Athens, AL 35611 USA.
EM malcolm.cort@athens.edu
OI Tull, Eugene S./0000-0002-6825-0511
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NR 59
TC 8
Z9 14
U1 0
U2 14
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0362-3319
EI 1873-5355
J9 SOC SCI J
JI Soc. Sci. J.
PD DEC
PY 2013
VL 50
IS 4
BP 557
EP 564
DI 10.1016/j.soscij.2013.04.001
PG 8
WC Social Sciences, Interdisciplinary
WE Social Science Citation Index (SSCI)
SC Social Sciences - Other Topics
GA AA5ML
UT WOS:000331143400017
DA 2025-06-11
ER

PT J
AU Zulet, MA
   Puchau, B
   Hermsdorff, HHM
   Navarro, C
   Martínez, JA
AF Zulet, M. Angeles
   Puchau, Blanca
   Hermsdorff, Helen H. M.
   Navarro, Cristina
   Martinez, J. Alfredo
TI Vitamin A Intake Is Inversely Related with Adiposity in Healthy Young
   Adults
SO JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY
LA English
DT Article
DE diet; vitamin A; antioxidant; adiposity; human
ID C-REACTIVE PROTEIN; BODY-MASS INDEX; RETINOIC ACID; DIETARY PATTERNS;
   SEGUIMIENTO-UNIVERSIDAD; VEGETABLE CONSUMPTION; ANTIOXIDANT CAPACITY;
   SERUM CONCENTRATIONS; INSULIN-RESISTANCE; BLOOD-PRESSURE
AB Dietary intake, either through specific nutrients or representative food groups, can influence obesity-related oxidative stress markers. This Study evaluated the potential associations between vitamin A intake and several anthropometrical, biochemical and dietary features in healthy young adults, emphasizing the putative relationships between total antioxidant consumption and vitamin A intake. This translational research enrolled 61 healthy young adults aged 18-22 y. Anthropometrical and blood pressure measurements, blood samples and nutritional intake data were collected. After adjusting for total energy intake, vitamin A intake showed a negative correlation with several adiposity measurements. Furthermore, vitamin A consumption was positively associated with serum total cholesterol as well as with the intake of antioxidant foodstuffs. So, vitamin A intake seems to be related. not only with the total antioxidant intake, but also with several anthropometrical and biochemical measurements linked to metabolic syndrome manifestations and other features related to oxidative stress in healthy young adults.
C1 [Zulet, M. Angeles; Puchau, Blanca; Hermsdorff, Helen H. M.; Navarro, Cristina; Martinez, J. Alfredo] Univ Navarra, Dept Nutr & Food Sci, Pamplona 31008, Spain.
C3 University of Navarra
RP Martínez, JA (corresponding author), Univ Navarra, Dept Nutr & Food Sci, C Irunlarrea 1, Pamplona 31008, Spain.
EM jalfmtz@unav.es
RI Martinez Hernandez, J Alfredo/K-8709-2014; Hermsdorff, Helen Hermana
   Miranda/H-4525-2015; Zulet, M. Angeles/H-1317-2017
OI Martinez Hernandez, J Alfredo/0000-0001-5218-6941; Hermsdorff, Helen
   Hermana Miranda/0000-0002-4441-6572; Zulet, M.
   Angeles/0000-0002-3926-0892
FU Linea Especial about Nutrition, Obesity and Health of the University of
   Navarra [LE/97]; Health Department of the Government of Navarra
   [22/2007]; CIBER; Ibercaja; the ADA fellowships scheme of the University
   of Navarra; Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior
   of the Brazilian Education Ministry [375605-0]
FX This Study was supported by the Linea Especial about Nutrition, Obesity
   and Health of the University of Navarra (LE/97), the Health Department
   of the Government of Navarra (22/2007). CIBER, Ibercaja, the ADA
   fellowships scheme of the University of Navarra, and the Coordenacao de
   Aperfeicoamento de Pessoal de Nivel Superior of the Brazilian Education
   Ministry (375605-0). We thank Veronica Ciaurriz and Ana Lorente for
   technical assistance, Blanca Martinez de Morentin and Salome Perez for
   assistance with the clinical data collection and all those who
   volunteered to participate in the study.
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NR 54
TC 52
Z9 53
U1 0
U2 3
PU CENTER ACADEMIC PUBL JAPAN
PI TOKYO
PA 2-4-16 YAYOI, BUNKYO-KU, TOKYO, 113-0032, JAPAN
SN 0301-4800
EI 1881-7742
J9 J NUTR SCI VITAMINOL
JI J. Nutr. Sci. Vitaminol.
PD OCT
PY 2008
VL 54
IS 5
BP 347
EP 352
DI 10.3177/jnsv.54.347
PG 6
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 367PZ
UT WOS:000260565600002
PM 19001764
OA gold
DA 2025-06-11
ER

PT J
AU Minciuna, I
   Gallage, S
   Heikenwalder, M
   Zelber-Sagi, S
   Dufour, JF
AF Minciuna, Iulia
   Gallage, Suchira
   Heikenwalder, Mathias
   Zelber-Sagi, Shira
   Dufour, Jean-Francois
TI Intermittent fasting-the future treatment in NASH patients?
SO HEPATOLOGY
LA English
DT Review
ID DISEASE RISK MARKERS; WEIGHT-LOSS; CIRCADIAN CLOCK; ENERGY RESTRICTION;
   BLOOD-PRESSURE; BODY-WEIGHT; HEALTH; TIME; METABOLISM; RHYTHMS
AB NASH is one of the leading causes of chronic liver disease with the potential of evolving towards end-stage liver disease and HCC, even in the absence of cirrhosis. Apart from becoming an increasingly prevalent indication for liver transplantation in cirrhotic and HCC patients, its burden on the healthcare system is also exerted by the increased number of noncirrhotic NASH patients. Intermittent fasting has recently gained more interest in the scientific community as a possible treatment approach for different components of metabolic syndrome. Basic science and clinical studies have shown that apart from inducing body weight loss, improving cardiometabolic parameters, namely blood pressure, cholesterol, and triglyceride levels; insulin and glucose metabolism; intermittent fasting can reduce inflammatory markers, endoplasmic reticulum stress, oxidative stress, autophagy, and endothelial dysfunction, as well as modulate gut microbiota. This review aims to further explore the main NASH pathogenetic metabolic drivers on which intermittent fasting can act upon and improve the prognosis of the disease, and summarize the current clinical evidence.
C1 [Minciuna, Iulia] Reg Inst Gastroenterol & Hepatol Octavian Fodor, Cluj Napoca, Romania.
   [Minciuna, Iulia] Univ Med & Pharm Iuliu Hatieganu, Cluj Napoca, Romania.
   [Gallage, Suchira] German Canc Res Ctr, Div Chron Inflammat & Canc, Heidelberg, Germany.
   [Gallage, Suchira; Heikenwalder, Mathias] Med Fac Tuebingen MFT, M3 Res Inst, Tubingen, Germany.
   [Heikenwalder, Mathias] German Canc Res Ctr, Div Chron Inflammat & Canc, Heidelberg, Germany.
   [Zelber-Sagi, Shira] Univ Haifa, Sch Publ Hlth, Fac Social Welf & Hlth Sci, Haifa, Israel.
   [Dufour, Jean-Francois] Ctr Digest Dis, Lausanne, Switzerland.
   [Dufour, Jean-Francois] Ctr Digest Dis, Ave Louis Ruchonnet 30, CH-1003 Lausanne, Switzerland.
C3 Regional Institute of Gastroenterology & Hepatology; Iuliu Hatieganu
   University of Medicine & Pharmacy; Helmholtz Association; German Cancer
   Research Center (DKFZ); Helmholtz Association; German Cancer Research
   Center (DKFZ); University of Haifa
RP Dufour, JF (corresponding author), Ctr Digest Dis, Ave Louis Ruchonnet 30, CH-1003 Lausanne, Switzerland.
EM iuliabreaban@yahoo.com; s.gallage@dkfz-heidelberg.de;
   m.heikenwaelder@dkfz-heidelberg.de; zelbersagi@bezeqint.net;
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NR 117
TC 18
Z9 19
U1 2
U2 11
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0270-9139
EI 1527-3350
J9 HEPATOLOGY
JI Hepatology
PD OCT
PY 2023
VL 78
IS 4
BP 1290
EP 1305
DI 10.1097/HEP.0000000000000330
EA APR 2023
PG 16
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA S8CB1
UT WOS:001068026500001
PM 37057877
DA 2025-06-11
ER

PT J
AU Jankovic, A
   Korac, A
   Buzadzic, B
   Stancic, A
   Otasevic, V
   Ferdinandy, P
   Daiber, A
   Korac, B
AF Jankovic, Aleksandra
   Korac, Aleksandra
   Buzadzic, Biljana
   Stancic, Ana
   Otasevic, Vesna
   Ferdinandy, Peter
   Daiber, Andreas
   Korac, Bato
TI Targeting the NO/superoxide ratio in adipose tissue: relevance to
   obesity and diabetes management
SO BRITISH JOURNAL OF PHARMACOLOGY
LA English
DT Review
ID NITRIC-OXIDE SYNTHASE; ACTIVATED PROTEIN-KINASE; ENDOPLASMIC-RETICULUM
   STRESS; ACID-BINDING PROTEIN; STIMULATES MITOCHONDRIAL BIOGENESIS;
   MEDIATED TYROSINE NITRATION; INCREASED OXIDATIVE STRESS; SOLUBLE
   GUANYLYL CYCLASE; INSULIN-RESISTANCE; REACTIVE OXYGEN
AB Insulin sensitivity and metabolic homeostasis depend on the capacity of adipose tissue to take up and utilize excess glucose and fatty acids. The key aspects that determine the fuel-buffering capacity of adipose tissue depend on the physiological levels of the small redox molecule, nitric oxide (NO). In addition to impairment of NO synthesis, excessive formation of the superoxide anion (?(center dot-)(2)) in adipose tissue may be an important interfering factor diverting the signalling of NO and other reactive oxygen and nitrogen species in obesity, resulting in metabolic dysfunction of adipose tissue over time. Besides its role in relief from superoxide burst, enhanced NO signalling may be responsible for the therapeutic benefits of different superoxide dismutase mimetics, in obesity and experimental diabetes models. This review summarizes the role of NO in adipose tissue and highlights the effects of NO/?(center dot-)(2) ratio teetering' as a promising pharmacological target in the metabolic syndrome.
C1 [Jankovic, Aleksandra; Buzadzic, Biljana; Stancic, Ana; Otasevic, Vesna; Korac, Bato] Univ Belgrade, Inst Biol Res Sinisa Stankovic, Dept Physiol, Bulevar Despota Stefana 142, Belgrade 11060, Serbia.
   [Korac, Aleksandra] Univ Belgrade, Ctr Electron Microscopy, Fac Biol, Belgrade, Serbia.
   [Ferdinandy, Peter] Semmelweis Univ, Dept Pharmacol & Pharmacotherapy, Budapest, Hungary.
   [Ferdinandy, Peter] Pharmahungary Grp, Szeged, Hungary.
   [Daiber, Andreas] Univ Med Ctr, Ctr Cardiol Cardiol 1, Mol Cardiol, Mainz, Germany.
C3 University of Belgrade; University of Belgrade; Semmelweis University;
   Pharmahungary Group; Johannes Gutenberg University of Mainz
RP Korac, B (corresponding author), Univ Belgrade, Inst Biol Res Sinisa Stankovic, Dept Physiol, Bulevar Despota Stefana 142, Belgrade 11060, Serbia.
EM koracb@ibiss.bg.ac.rs
RI Ferdinandy, Péter/H-9181-2019; Daiber, Andreas/HJY-5274-2023; Stancic,
   Ana/AAA-8051-2019; Korac, Bato/AAH-8206-2021; Otasevic,
   Vesna/U-2242-2017; Jankovic, Aleksandra/ACV-5778-2022
OI Otasevic, Vesna/0000-0001-8660-8284; Korac, Bato/0000-0001-5272-579X;
   Stancic, Ana/0000-0003-0806-0799; Jankovic,
   Aleksandra/0000-0002-6945-927X
FU Ministry of Education, Science and Technological Development of the
   Republic of Serbia [173055]; European Cooperation in Science and
   Technology (COST Action) [BM1203/EU-ROS]
FX This work was supported by the Ministry of Education, Science and
   Technological Development of the Republic of Serbia (grant no. 173055)
   and the European Cooperation in Science and Technology (COST Action
   BM1203/EU-ROS).
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NR 248
TC 38
Z9 41
U1 1
U2 35
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0007-1188
EI 1476-5381
J9 BRIT J PHARMACOL
JI Br. J. Pharmacol.
PD JUN
PY 2017
VL 174
IS 12
SI SI
BP 1570
EP 1590
DI 10.1111/bph.13498
PG 21
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA EV9YH
UT WOS:000402143300005
PM 27079449
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Kanbay, M
   Sánchez-Lozada, LG
   Franco, M
   Madero, M
   Solak, Y
   Rodriguez-Iturbe, B
   Covic, A
   Johnson, RJ
AF Kanbay, Mehmet
   Sanchez-Lozada, Laura-Gabriela
   Franco, Martha
   Madero, Magdalena
   Solak, Yalcin
   Rodriguez-Iturbe, Bernardo
   Covic, Adrian
   Johnson, Richard J.
TI Microvascular disease and its role in the brain and cardiovascular
   system: a potential role for uric acid as a cardiorenal toxin
SO NEPHROLOGY DIALYSIS TRANSPLANTATION
LA English
DT Review
DE arteriolosclerosis; autoregulation; chronic kidney disease; fructose;
   uric acid
ID SALT-SENSITIVE HYPERTENSION; MUSCLE-CELL-PROLIFERATION; CHRONIC
   KIDNEY-DISEASE; OXIDATIVE STRESS; BLOOD-PRESSURE; COGNITIVE FUNCTION;
   RENAL INJURY; GLOMERULAR HYPERTENSION; METABOLIC SYNDROME; FRUCTOSE
   INTAKE
AB Arteriolosclerosis (microvascular disease) may have a key role not only in driving salt-sensitive hypertension but also in mediating the development of chronic kidney disease, vascular dementia, stroke and coronary heart disease. In this paper, we review the evidence that these latter conditions result from the altered autoregulation that occurs when arterioles become diseased. We also discuss the increasing evidence that dietary intake of sugars rich in fructose may be driving the development of microvascular disease as a consequence of raising intracellular uric acid. We hypothesize that the treatment of microvascular disease may require a multifaceted approach by utilizing agents which aim at blocking of the renin-angiotensin system, reducing oxidative stress, stimulating endothelial nitric oxide production and lowering uric acid levels. Paradoxically, agents that only stimulate nitric oxide, such as oestrogens, may increase the risk of poor outcomes if microvascular disease is not reversed.
C1 [Kanbay, Mehmet] Gulhane Mil Med Acad, Dept Med, Div Nephrol, Ankara, Turkey.
   [Sanchez-Lozada, Laura-Gabriela; Franco, Martha; Madero, Magdalena] INC Ignacio Chavez, Dept Nephrol, Mexico City, DF, Mexico.
   [Solak, Yalcin] Selcuk Univ, Meram Sch Med, Dept Med, Div Nephrol, Konya, Turkey.
   [Rodriguez-Iturbe, Bernardo] Univ Zulia, IVIC Zulia, Maracaibo 4011, Venezuela.
   [Rodriguez-Iturbe, Bernardo] Univ Hosp, Serv Nefrol, Maracaibo, Venezuela.
   [Covic, Adrian] Gr T Popa Univ Med & Pharm, CI PARHON Univ Hosp, Dialysis & Renal Transplant Ctr, Nephrol Clin, Iasi, Romania.
   [Johnson, Richard J.] Univ Colorado, Div Renal Dis & Hypertens, Denver, CO 80202 USA.
C3 Gulhane Military Medical Academy; Selcuk University; Grigore T Popa
   University of Medicine & Pharmacy; National Institute of Endocrinology
   C.I. Parhon; University of Colorado System; University of Colorado
   Denver
RP Kanbay, M (corresponding author), Gulhane Mil Med Acad, Dept Med, Div Nephrol, Ankara, Turkey.
EM drkanbay@yahoo.com
RI Franco, Martha/H-2759-2017; 1, 1/L-6277-2019; Solak,
   Yalcin/AAD-1393-2020; Sanchez-Lozada, Laura/AAS-2104-2021; Covic,
   Adrian/G-5017-2016
OI Sanchez-Lozada, Laura-Gabriela/0000-0003-0348-9617; Franco,
   Martha/0000-0003-4073-524X
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NR 82
TC 65
Z9 73
U1 0
U2 6
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0931-0509
EI 1460-2385
J9 NEPHROL DIAL TRANSPL
JI Nephrol. Dial. Transplant.
PD FEB
PY 2011
VL 26
IS 2
BP 430
EP 437
DI 10.1093/ndt/gfq635
PG 9
WC Transplantation; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Transplantation; Urology & Nephrology
GA 712OF
UT WOS:000286675400007
PM 20935013
OA Bronze
DA 2025-06-11
ER

PT J
AU Carillon, J
   Romain, C
   Bardy, G
   Fouret, G
   Feillet-Coudray, C
   Gaillet, S
   Lacan, D
   Cristol, JP
   Rouanet, JM
AF Carillon, Julie
   Romain, Cindy
   Bardy, Guillaume
   Fouret, Gilles
   Feillet-Coudray, Christine
   Gaillet, Sylvie
   Lacan, Dominique
   Cristol, Jean-Paul
   Rouanet, Jean-Max
TI Cafeteria diet induces obesity and insulin resistance associated with
   oxidative stress but not with inflammation: improvement by dietary
   supplementation with a melon superoxide dismutase
SO FREE RADICAL BIOLOGY AND MEDICINE
LA English
DT Article
DE Antioxidant defense; Inflammatory markers; Insulin sensitivity; Obesity;
   Oxidative status; Free radicals
ID FATTY LIVER-DISEASE; NF-KAPPA-B; METABOLIC SYNDROME; NONALCOHOLIC
   STEATOHEPATITIS; RESPIRATORY-CHAIN; ADIPOSE-TISSUE; NRF2; GLUCOSE;
   SENSITIVITY; ACTIVATION
AB Oxidative stress is involved in obesity. However, dietary antioxidants could prevent oxidative stress-induced damage. We have previously shown the preventive effects of a melon superoxide dismutase.(SODB) on oxidative stress. However, the mechanism of action of SODB is still unknown. Here, we evaluated the effects of a 1-month curative supplementation with SODB on the liver of obese hamsters. Golden Syrian hamsters received either a standard diet or a cafeteria diet composed of high-fat, high-sugar, and high-salt supermarket products, for 15 weeks. This diet resulted in insulin resistance and in increased oxidative stress in the liver. However, inflammatory markers (IL-6, TNF-alpha, and NF-kappa B) were not enhanced and no liver steatosis was detected, although these are usually described in obesity-induced insulin resistance models. After the 1-month supplementation with SODB, body weight and insulin resistance induced by the cafeteria diet were reduced and hepatic oxidative stress was corrected. This could be due to the increased expression of the liver antioxidant defense proteins (manganese and copper/zinc superoxide dismutase, catalase, and glutathione peroxidase). Even though no inflammation was detected in the obese hamsters, inflammatory Markers were decreased after SODB supplementation, probably through the reduction of oxidative stress. These findings suggest for the first time that SODB could exert its antioxidant properties by inducing the endogenous antioxidant defense. The mechanisms underlying this induction need to be further investigated. (C) 2013 Elsevier Inc. All rights reserved.
C1 [Carillon, Julie; Romain, Cindy; Gaillet, Sylvie; Cristol, Jean-Paul; Rouanet, Jean-Max] Univ Montpellier 1 2, UMR NutriPass Prevent Malnutr & Pathol Assoc 204, F-34095 Montpellier 05, France.
   [Carillon, Julie; Lacan, Dominique] Bionov Sarl, Avignon, France.
   [Bardy, Guillaume; Cristol, Jean-Paul] Univ Montpellier I, Ctr Hosp Univ Montpellier, Dept Bioquim, Montpellier, France.
   [Fouret, Gilles; Feillet-Coudray, Christine] INRA, UMR 866, Unite Differenciat Cellulaire & Croissance, F-34060 Montpellier, France.
C3 Universite de Montpellier; Universite de Montpellier; CHU de
   Montpellier; INRAE; Universite de Montpellier
RP Rouanet, JM (corresponding author), Univ Montpellier 1 2, UMR NutriPass Prevent Malnutr & Pathol Assoc 204, F-34095 Montpellier 05, France.
EM jm.rouanet@univ-montp2.fr
RI COUDRAY, Charles/AGG-4757-2022
OI , Jean-Paul Cristol/0000-0001-8563-7278
FU CIFRE grant (Convention Industrie Ile de Formation par la Recherche,
   from Bionov (Avignon, France) [0417/2010]; French Association Nationale
   de la Recherche et de la Technologie
FX Julie Carillon was supported by a CIFRE grant (Convention Industrie Ile
   de Formation par la Recherche, No. 0417/2010) from Bionov (Avignon,
   France) and the French Association Nationale de la Recherche et de la
   Technologie. Dominique Lacan is the R&D director at Bionov. The authors
   are grateful to Stephanie Bayol for her help in the conception of animal
   diets.
CR [Anonymous], NIH PUBL
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NR 80
TC 51
Z9 54
U1 0
U2 16
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0891-5849
EI 1873-4596
J9 FREE RADICAL BIO MED
JI Free Radic. Biol. Med.
PD DEC
PY 2013
VL 65
BP 254
EP 261
DI 10.1016/j.freeradbiomed.2013.06.022
PG 8
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 278DI
UT WOS:000328868900025
PM 23792771
DA 2025-06-11
ER

PT J
AU Singh, S
   Pal, N
   Shubham, S
   Sarma, DK
   Verma, V
   Marotta, F
   Kumar, M
AF Singh, Samradhi
   Pal, Namrata
   Shubham, Swasti
   Sarma, Devojit Kumar
   Verma, Vinod
   Marotta, Francesco
   Kumar, Manoj
TI Polycystic Ovary Syndrome: Etiology, Current Management, and Future
   Therapeutics
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Review
DE PCOS; gut microbiome; probiotics; FMT; gut dysbiosis; hyperinsulinemia;
   hyperandrogenism; metabolic disorders; miRNA therapy
ID D-CHIRO-INOSITOL; DOUBLE-BLIND; VITAMIN-D; SYNDROME PCOS; INSULIN
   SENSITIVITY; DIAGNOSTIC-CRITERIA; ORAL-CONTRACEPTION; METABOLIC FACTORS;
   OXIDATIVE STRESS; GUT MICROBIOTA
AB Polycystic ovary syndrome (PCOS) is a complex endocrine and metabolic disorder, typically characterized by anovulation, infertility, obesity, insulin resistance, and polycystic ovaries. Lifestyle or diet, environmental pollutants, genetics, gut dysbiosis, neuroendocrine alterations, and obesity are among the risk factors that predispose females to PCOS. These factors might contribute to upsurging metabolic syndrome by causing hyperinsulinemia, oxidative stress, hyperandrogenism, impaired folliculogenesis, and irregular menstrual cycles. Dysbiosis of gut microbiota may play a pathogenic role in the development of PCOS. The restoration of gut microbiota by probiotics, prebiotics, or a fecal microbiota transplant (FMT) might serve as an innovative, efficient, and noninvasive way to prevent and mitigate PCOS. This review deliberates on the variety of risk factors potentially involved in the etiology, prevalence, and modulation of PCOS, in addition to plausible therapeutic interventions, including miRNA therapy and the eubiosis of gut microbiota, that may help treat and manage PCOS.
C1 [Singh, Samradhi; Pal, Namrata; Shubham, Swasti; Sarma, Devojit Kumar; Kumar, Manoj] ICMR Natl Inst Res Environm Hlth, Bhopal Bypass Rd, Bhopal 462030, India.
   [Verma, Vinod] Sanjay Gandhi Postgrad Inst MedicalSci, Stem Cell Res Ctr, Dept Hematol, Lucknow 226014, India.
   [Marotta, Francesco] ReGenera R&D Int Aging Intervent, I-20144 Milan, Lombardy, Italy.
C3 Indian Council of Medical Research (ICMR); ICMR - National Institute for
   Research in Environmental Health (NIREH)
RP Kumar, M (corresponding author), ICMR Natl Inst Res Environm Hlth, Bhopal Bypass Rd, Bhopal 462030, India.; Marotta, F (corresponding author), ReGenera R&D Int Aging Intervent, I-20144 Milan, Lombardy, Italy.
EM fmarchimede@libero.it; manoj15ndri@gmail.com
RI Sarma, Dr. Devojit Kumar/AAE-3003-2022; Pal, Namrata/KAM-2924-2024;
   Sarma, Devojit Kumar/D-4337-2013
OI Sarma, Devojit Kumar/0000-0002-2749-4114; KUMAR,
   MANOJ/0000-0002-2040-8631
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NR 156
TC 155
Z9 162
U1 33
U2 129
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD FEB
PY 2023
VL 12
IS 4
AR 1454
DI 10.3390/jcm12041454
PG 24
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 9H0KI
UT WOS:000938530400001
PM 36835989
OA gold, Green Published
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Watanabe, LM
   Hashimoto, AC
   Torres, DJ
   Alfulaij, N
   Peres, R
   Sultana, R
   Maunakea, AK
   Berry, MJ
   Seale, LA
AF Watanabe, Ligia M.
   Hashimoto, Ann C.
   Torres, Daniel J.
   Alfulaij, Naghum
   Peres, Rafael
   Sultana, Razvan
   Maunakea, Alika K.
   Berry, Marla J.
   Seale, Lucia A.
TI Effect of statin treatment in obese selenium-supplemented mice lacking
   selenocysteine lyase
SO MOLECULAR AND CELLULAR ENDOCRINOLOGY
LA English
DT Article
DE Selenium; Selenocysteine lyase; Obesity; Statin
ID SELENOPROTEIN SYNTHESIS; METABOLIC SYNDROME; SKELETAL-MUSCLE;
   TRANSFER-RNA; DEFICIENCY; ISOPENTENYLADENOSINE; MECHANISMS; SYMPTOMS;
   KINASE
AB People with obesity are often dyslipidemic and prescribed statins to prevent cardiovascular events. A common side effect of statin use is myopathy. This could potentially be caused by the reduction of selenoproteins that curb oxidative stress, in turn, affecting creatine metabolism. We determined if statins regulate hepatic and muscular selenoprotein expression, oxidative stress and creatine metabolism. Mice lacking selenocysteine lyase (Scly KO), a selenium-provider enzyme for selenoprotein synthesis, were fed a high-fat, Se-supplemented diet and treated with simvastatin. Statin improved creatine metabolism in females and oxidative responses in both sexes. Male Scly KO mice were heavier than females after statin treatment. Hepatic selenoproteins were unaffected by statin and genotype in females. Statin upregulated muscular Gpx1 in females but not males, while Scly loss downregulated muscular Gpx1 in males and Selenon in females. Osgin1 was reduced in statin-treated Scly KO males after AmpliSeq analysis. These results refine our understanding of the sex-dependent role of selenium in statin responses.
C1 [Watanabe, Ligia M.; Hashimoto, Ann C.; Torres, Daniel J.; Alfulaij, Naghum] Univ Hawaii Manoa, John A Burns Sch Med, Dept Cell & Mol Biol, Honolulu, HI 96813 USA.
   [Watanabe, Ligia M.] Univ Sao Paulo FMRP USP, Fac Med Ribeirao Preto, Dept Internal Med, Sao Paulo, Brazil.
   [Peres, Rafael; Sultana, Razvan; Maunakea, Alika K.] Univ Hawaii Manoa, John A Burns Sch Med, Dept Anat Biochem & Physiol, Honolulu, HI 96813 USA.
   [Torres, Daniel J.; Alfulaij, Naghum; Berry, Marla J.; Seale, Lucia A.] Univ Hawaii Manoa, Pacific Biosci Res Ctr, Sch Ocean & Earth Sci & Technol, Honolulu, HI 96822 USA.
C3 University of Hawaii System; University of Hawaii Manoa; Universidade de
   Sao Paulo; University of Hawaii System; University of Hawaii Manoa;
   University of Hawaii System; University of Hawaii Manoa
RP Seale, LA (corresponding author), Univ Hawaii Manoa, Pacific Biosci Res Ctr, Sch Ocean & Earth Sci & Technol, Honolulu, HI 96822 USA.
EM lseale@hawaii.edu
RI Watanabe, Ligia/AAK-8539-2020; Torres, Daniel/ACU-0207-2022; Seale,
   Lucia/AFT-9036-2022
OI Torres, Daniel/0000-0002-4451-712X; Seale, Lucia/0000-0002-0686-7516;
   Alfulaij, Naghum/0000-0002-3997-7973; Sultana,
   Razvan/0000-0002-6563-6267; Berry, Marla/0000-0002-2428-586X; Moriguchi
   Watanabe, Ligia/0000-0001-7498-6165; Maunakea, Alika/0000-0002-6457-5087
FU National Institutes of Health (NIH) - Centers of Biomedical Research
   Excellence (COBRE) in Diabetes [P20GM113134]; Hawaii Community
   Foundation [20ADVC-102166]; NIH [R01DK047320, U54MD007601, 5544,
   R01DK128390, F32DK124963, R01DK047320-22S2]; NIH Office of Dietary
   Supplements (ODS) [R01DK047320-22S1]; Fundacao de Amparo a Pesquisa do
   Estado de Sao Paulo (FAPESP) [2018/09478-4]; National Institute of
   General Medical Sciences [P20GM113134] Funding Source: NIH RePORTER
FX We thank the Epigenomics Core Facility of Hawaii from the University of
   Hawaii John A. Burns School of Medicine (UH-JABSOM) for Ampli-Seq
   analysis assistance. This core was partially supported by the National
   Institutes of Health (NIH) grant P20GM113134 - Centers of Biomedical
   Research Excellence (COBRE) in Diabetes, which also provided partial
   support AmpliSeq analysis via the Diabetes Dollars Program to LAS.
   Further support was provided by the Hawaii Community Foundation grant
   20ADVC-102166 to LAS; NIH grants R01DK047320 to MJB; U54MD007601
   -Subproject 5544 and R01DK128390 to LAS; F32DK124963 and a Research
   Supplement to Promote Diversity in Health-Related Research,
   R01DK047320-22S2 to DJT; and an Administrative Supplement for Research
   on Dietary Supplements from the NIH Office of the Director (OD) and
   co-funded by the NIH Office of Dietary Supplements (ODS),
   R01DK047320-22S1 to MJB; an Associate Dean for Research Core Credits
   Program from UH-JABSOM to LAS; and fellowship 2018/09478-4 from Fundacao
   de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) to LMW. The content
   of this publication is solely the responsibility of the authors and does
   not necessarily represent the official views of the NIH. We are grateful
   to Natalia Yumi Noronha (University of Sao Paulo) in the preparation of
   Fig. 1.
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NR 54
TC 8
Z9 8
U1 0
U2 6
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0303-7207
EI 1872-8057
J9 MOL CELL ENDOCRINOL
JI Mol. Cell. Endocrinol.
PD AUG 1
PY 2021
VL 533
AR 111335
DI 10.1016/j.mce.2021.111335
EA JUN 2021
PG 10
WC Cell Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Endocrinology & Metabolism
GA TM9SD
UT WOS:000675885500007
PM 34052303
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Mazzocco, JC
   Jagadapillai, R
   Gozal, E
   Kong, MY
   Xu, Q
   Barnes, GN
   Freedman, JH
AF Mazzocco, John C.
   Jagadapillai, Rekha
   Gozal, Evelyne
   Kong, Maiying
   Xu, Qian
   Barnes, Gregory N.
   Freedman, Jonathan H.
TI Disruption of essential metal homeostasis in the brain by cadmium and
   high-fat diet
SO TOXICOLOGY REPORTS
LA English
DT Article
DE Cadmium; Brain; Obesity; Trace elements; Metal homeostasis; Oxidative
   stress
ID OCCUPATIONAL-EXPOSURE; GENDER-DIFFERENCES; METABOLIC SYNDROME; OXIDATIVE
   STRESS; NATIONAL-HEALTH; AGE; OBESITY; BLOOD; NEURODEVELOPMENT; CHILDREN
AB Analyses of human cohort data support the roles of cadmium and obesity in the development of several neurocognitive disorders. To explore the effects of cadmium exposure in the brain, mice were subjected to whole life oral cadmium exposure. There were significant increases in cadmium levels with female animals accumulating more metal than males (p < 0.001). Both genders fed a high fat diet showed significant increases in cadmium levels compared to low fat diet fed mice (p < 0.001). Cadmium and high fat diet significantly affected the levels of several essential metals, including magnesium, potassium, chromium, iron, cobalt, copper, zinc and selenium. Additionally, these treatments resulted in increased superoxide levels within the cortex, amygdala and hippo campus. These findings support a model where cadmium and high fat diet affect the levels of redox-active, essential metal homeostasis. This phenomenon may contribute to the underlying mechanism(s) responsible for the development of neurocognitive disorders.
C1 [Mazzocco, John C.; Jagadapillai, Rekha; Gozal, Evelyne] Univ Louisville, Sch Med, Dept Pediat, Louisville, KY 40292 USA.
   [Kong, Maiying; Xu, Qian] Univ Louisville, Sch Publ Hlth & Informat Sci, Dept Bioinformat & Biostat, Louisville, KY 40292 USA.
   [Barnes, Gregory N.] Univ Louisville, Sch Med, Dept Neurol, Louisville, KY 40292 USA.
   [Gozal, Evelyne; Freedman, Jonathan H.] Univ Louisville, Sch Med, Dept Pharmacol & Toxicol, Louisville, KY 40292 USA.
C3 University of Louisville; University of Louisville; University of
   Louisville; University of Louisville
RP Freedman, JH (corresponding author), Univ Louisville, Sch Med, Dept Pharmacol & Toxicol, Louisville, KY 40292 USA.; Barnes, GN (corresponding author), Univ Louisville, Sch Med, Dept Neurol, Autism Ctr, Louisville, KY 40202 USA.
EM gregory.barnes@louisville.edu; jonathan.freedman@louisville.edu
RI Jagadapillai, Rekha/GLS-6828-2022
OI Jagadapillai, Rekha/0000-0002-6016-9946
FU National Institute of Environmental Health Sciences, National Institutes
   of Health [R01ES028102, T35ES14559]; Institutional Development Award
   (IDeA) from the National Institute of General Medical Sciences of the
   National Institutes of Health [P20GM113226-6176]
FX This study was funded in part by National Institute of Environmental
   Health Sciences, National Institutes of Health (R01ES028102 and
   T35ES14559), Institutional Development Award (IDeA) from the National
   Institute of General Medical Sciences of the National Institutes of
   Health (P20GM113226-6176).
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NR 60
TC 17
Z9 18
U1 0
U2 6
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
EI 2214-7500
J9 TOXICOL REP
JI Toxicol. Rep.
PY 2020
VL 7
BP 1164
EP 1169
DI 10.1016/j.toxrep.2020.08.005
PG 6
WC Toxicology
WE Emerging Sources Citation Index (ESCI)
SC Toxicology
GA PN3BP
UT WOS:000604358300005
PM 32983904
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Zheng, ZX
   Yu, XB
AF Zheng, Zhaoxia
   Yu, Xiaobing
TI Insulin resistance in the retina: possible implications for certain
   ocular diseases
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Review
DE insulin resistance; retina; diabetic retinopathy; glaucoma; age related
   macular degeneration
ID INCREASED INTRAOCULAR-PRESSURE; METABOLIC SYNDROME; OXIDATIVE STRESS;
   MACULAR DEGENERATION; DIABETIC-RETINOPATHY; GLOBAL PREVALENCE;
   FREE-RADICALS; RECEPTOR; DYSFUNCTION; BRAIN
AB Insulin resistance (IR) is becoming a worldwide medical and public health challenge as an increasing prevalence of obesity and metabolic disorders. Accumulated evidence has demonstrated a strong relationship between IR and a higher incidence of several dramatically vision-threatening retinal diseases, including diabetic retinopathy, age-related macular degeneration, and glaucoma. In this review, we provide a schematic overview of the associations between IR and certain ocular diseases and further explore the possible mechanisms. Although the exact causes explaining these associations have not been fully elucidated, underlying mechanisms of oxidative stress, chronic low-grade inflammation, endothelial dysfunction and vasoconstriction, and neurodegenerative impairments may be involved. Given that IR is a modifiable risk factor, it may be important to identify patients at a high IR level with prompt treatment, which may decrease the risk of developing certain ocular diseases. Additionally, improving IR through the activation of insulin signaling pathways could become a potential therapeutic target.
C1 [Zheng, Zhaoxia; Yu, Xiaobing] Chinese Acad Med Sci, Beijing Hosp, Inst Geriatr Med, Natl Ctr Gerontol, Beijing, Peoples R China.
   [Zheng, Zhaoxia; Yu, Xiaobing] Peking Union Med Coll, Grad Sch, Beijing, Peoples R China.
C3 Beijing Hospital; Chinese Academy of Medical Sciences - Peking Union
   Medical College; Chinese Academy of Medical Sciences - Peking Union
   Medical College; Peking Union Medical College
RP Yu, XB (corresponding author), Chinese Acad Med Sci, Beijing Hosp, Inst Geriatr Med, Natl Ctr Gerontol, Beijing, Peoples R China.; Yu, XB (corresponding author), Peking Union Med Coll, Grad Sch, Beijing, Peoples R China.
EM yuxiaobing1214@163.com
FU National High Level Hospital Clinical Research Funding [BJ-2022-104]
FX The author(s) declare financial support was received for the research,
   authorship, and/or publication of this article. This work was supported
   by the National High Level Hospital Clinical Research Funding [grant
   number: BJ-2022-104].
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NR 124
TC 5
Z9 5
U1 5
U2 7
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD JUN 17
PY 2024
VL 15
AR 1415521
DI 10.3389/fendo.2024.1415521
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA WW9H1
UT WOS:001258019800001
PM 38952394
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Park, JS
   Lee, WK
   Kim, HS
   Seo, JA
   Kim, DH
   Han, HC
   Min, BH
AF Park, Jin-Sung
   Lee, Woon-Kyu
   Kim, Hyeon Soo
   Seo, Ji A.
   Kim, Dong-Hoon
   Han, Hee Chul
   Min, Bon-Hong
TI Clusterin overexpression protects against western diet-induced obesity
   and NAFLD
SO SCIENTIFIC REPORTS
LA English
DT Article
ID FATTY LIVER-DISEASE; NONALCOHOLIC STEATOHEPATITIS;
   CARDIOVASCULAR-DISEASE; INCREASED EXPRESSION; THERAPEUTIC TARGET;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; OXIDATIVE STRESS; AMPK
   ACTIVATION; ADIPOSE-TISSUE
AB Obesity is a significant risk factor for various metabolic diseases and is closely related to non-alcoholic fatty liver disease (NAFLD) characterized by inflammation and oxidative stress. Clusterin is a multi-functional protein that is up-regulated in the pathogenesis of various metabolic diseases, including obesity and NAFLD. Our previous studies indicated that hepatocyte-specific overexpression of clusterin alleviates methionine choline-deficient (MCD) diet-induced non-alcoholic steatohepatitis (NASH) by activating nuclear factor erythroid 2-related factor 2 (Nrf2). Here we generated transgenic mice with whole-body clusterin overexpression (wCLU-tg) and investigated the role of clusterin in Western diet-induced obesity and NAFLD. We confirmed that obesity parameters and the spectrum of NAFLD of wCLU-tg mice were improved compared to wild type mice. Contrarily, clusterin deficiency deteriorated metabolic disruptions. We also found that clusterin activates target molecules for obesity and NAFLD, namely Nrf2 and AMPK, suggesting that clusterin protects against Western diet-induced obesity and NAFLD by activating Nrf2 and AMPK.
C1 [Park, Jin-Sung; Han, Hee Chul] Korea Univ, Dept Physiol, Coll Med, Seoul, South Korea.
   [Lee, Woon-Kyu] Inha Univ, Dept Biomed Sci, Coll Med, Incheon, South Korea.
   [Kim, Hyeon Soo] Korea Univ, Dept Anat, Coll Med, Seoul, South Korea.
   [Seo, Ji A.] Korea Univ, Dept Endocrinol & Metab, Ansan, South Korea.
   [Park, Jin-Sung; Kim, Dong-Hoon; Min, Bon-Hong] Korea Univ, Dept Pharmacol, Coll Med, Seoul, South Korea.
C3 Korea University; Korea University Medicine (KU Medicine); Inha
   University; Korea University; Korea University Medicine (KU Medicine);
   Korea University; Korea University; Korea University Medicine (KU
   Medicine)
RP Min, BH (corresponding author), Korea Univ, Dept Pharmacol, Coll Med, Seoul, South Korea.
EM bhmin@korea.ac.kr
RI SEO, JI/AAU-7968-2020; Kim, Sung/F-7292-2013; Han, Hee/AAH-2294-2019;
   Choi, You-Jung/AFR-4193-2022; LEE, HYUN/ABC-6119-2021; Park,
   Hui/AAS-5243-2020
OI Han, Hee Chul/0000-0003-0374-8690
FU Basic Science Research Program through the National Research Foundation
   of Korea (NRF) - Ministry of Education [2015R1D1A1A01058467,
   2018R1D1A1B07051085]
FX This research was supported by Basic Science Research Program through
   the National Research Foundation of Korea (NRF) funded by the Ministry
   of Education (grant numbers: 2015R1D1A1A01058467 and
   2018R1D1A1B07051085).
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PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD OCT 15
PY 2020
VL 10
IS 1
AR 17484
DI 10.1038/s41598-020-73927-y
PG 11
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA OH6ML
UT WOS:000582705900098
PM 33060605
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Zeng, X
   Huang, Q
   Long, SL
   Zhong, QQ
   Mo, ZC
AF Zeng, Xin
   Huang, Qin
   Long, Shuang Lian
   Zhong, Qiaoqing
   Mo, Zhongcheng
TI Mitochondrial Dysfunction in Polycystic Ovary Syndrome
SO DNA AND CELL BIOLOGY
LA English
DT Article
DE mitochondrion; reproductive metabolism; polycystic ovary syndrome;
   follicular development
ID INSULIN-RESISTANCE; OXIDATIVE STRESS; SKELETAL-MUSCLE; GRANULOSA-CELLS;
   WOMEN; EXPRESSION; PATHWAY; CONSEQUENCES; INFLAMMATION; GLUTATHIONE
AB Polycystic ovary syndrome (PCOS) is one of the most common female reproductive metabolisms. It is an endocrine disease that affects reproductive women and often exhibits with hyperandrogenemia, insulin resistance (IR), low inflammation, and an increased risk of type 2 diabetes mellitus, metabolic syndrome, and cardiovascular events such as hypertension and dyslipidemia in patients. However, the molecular mechanism of PCOS is still unclear. Recently, an increasing number of studies have shown that the oxidative stress induced by mitochondrial dysfunction has negative effects on IR, lipid metabolism, and follicular development, suggesting that mitochondrial dysfunction plays an essential role in the development of PCOS. Abnormal mitochondrial DNA copy number in patients with PCOS, and mitochondrial gene mutations, has been the focus of research in recent years, and functional mitochondrial diseases have been gradually accepted as a related factor in PCOS. This review is intended to summarize and discuss previous and recent studies and findings on the connections between mitochondrial dysfunction and PCOS.
C1 [Zeng, Xin; Huang, Qin; Long, Shuang Lian; Mo, Zhongcheng] Univ South China, Hengyang Med Sch, Clin Anat & Reprod Med Applicat Inst, Dept Histol & Embryol, Hengyang, Hunan, Peoples R China.
   [Zhong, Qiaoqing] Cent South Univ, Xiangya Hosp, Dept Cardiovasc Med, Changsha 410008, Peoples R China.
   [Mo, Zhongcheng] Guilin Med Univ, Inst Basic Med Sci, Guilin 541100, Guangxi, Peoples R China.
C3 University of South China; Central South University; Guilin Medical
   University
RP Zhong, QQ (corresponding author), Cent South Univ, Xiangya Hosp, Dept Cardiovasc Med, Changsha 410008, Peoples R China.; Mo, ZC (corresponding author), Guilin Med Univ, Inst Basic Med Sci, Guilin 541100, Guangxi, Peoples R China.
EM qiaoqingzhong@csu.edu.cn; zhchmo@hotmail.com
RI 莫, 中成/AAY-8561-2020
FU Natural Sciences Foundation of Hunan Province [2019JJ40248, 2018JJ2663];
   Key Lab for Clinical Anatomy & Reproductive Medicine of Hengyang City
   [2017KJ182]; Chuanshan Talents Project in the University of South China
FX We appreciate the Natural Sciences Foundation of Hunan Province
   (2019JJ40248, 2018JJ2663), the Key Lab for Clinical Anatomy &
   Reproductive Medicine of Hengyang City (2017KJ182), and the Chuanshan
   Talents Project in the University of South China.
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NR 68
TC 34
Z9 38
U1 2
U2 30
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1044-5498
EI 1557-7430
J9 DNA CELL BIOL
JI DNA Cell Biol.
PD AUG 1
PY 2020
VL 39
IS 8
BP 1401
EP 1409
DI 10.1089/dna.2019.5172
EA FEB 2020
PG 9
WC Biochemistry & Molecular Biology; Cell Biology; Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology; Genetics & Heredity
GA MU1AS
UT WOS:000515272500001
PM 32077751
DA 2025-06-11
ER

PT J
AU Ozkul, A
   Ayhan, M
   Akyol, A
   Turgut, ET
   Kadikoylu, G
   Yenisey, C
AF Ozkul, Ayca
   Ayhan, Mediha
   Akyol, Ali
   Turgut, Eylem Telli
   Kadikoylu, Gurhan
   Yenisey, Cigdem
TI The effect of insulin resistance on inflammatory response and oxidative
   stress in acute cerebral ischemia
SO NEUROENDOCRINOLOGY LETTERS
LA English
DT Article
DE insulin resistance; stroke; inflammation; oxidative stress; interleukin
ID NITRIC-OXIDE; BRAIN-DAMAGE; STROKE; CYTOKINES; INTERLEUKIN-10; SERUM;
   CLASSIFICATION; SECRETION; TISSUE
AB OBJECTIVE: Insulin resistance (IR) has effects on inflammation and oxidative stress which have importance in acute stroke. Our aim was to investigate the relationships between IR, inflammation, oxidative stress and stroke severity in acute ischemic stroke patients.
   METHODS: We examined the relationships between inflammation, oxidative stress and stroke severity in 75 acute stroke patients with and without IR. Serum levels of oxidative stress markers (nitric oxide (NO), malondialdehyde (MDA), glutathione (GSH)) were measured as well as the cytokines interleukin-6 (IL-6) and interleukin-10 (IL-10).
   RESULTS: The levels of IL-10 (13.7 +/- 19.11 vs 51.20 +/- 89.32 pg/ml, p<0.00) in IR group were significantly reduced. Patients with IR had higher levels of NO (30.26 +/- 17.63 vs 22.57 +/- 14.5 mu mol/L, p=0.04) and IL6 (27.44 +/- 57.13 vs 8.68 +/- 11.8 pg/ml, p<0.00) and higher NIHSS scores (11.40 +/- 5.35 vs 8.81 +/- 5.76, p=0.04) when compared with noninsulin resistant group. IL-10 was found negatively correlated with HOMA. Additionally, the parameters with positive correlations with HOMA were NIHSS, IL-6 and NO.
   CONCLUSIONS: Inflammation and oxidative stress are more evident in acute stoke patients with insulin resistance which may cause worse stroke severity. Our data also suggest that IL-10 as an antiinflammatory cytokine can be much lower in insulin resistance in acute phase of ischemic stroke. However it can be elevated as an adaptive mechanism in metabolic syndrome as a chronic condition.
C1 [Ozkul, Ayca; Akyol, Ali; Turgut, Eylem Telli] Adnan Menderes Univ, Fac Med, Dept Neurol, TR-09100 Aydin, Turkey.
   [Ayhan, Mediha] Adnan Menderes Univ, Fac Med, Dept Endocrinol, TR-09100 Aydin, Turkey.
   [Kadikoylu, Gurhan] Adnan Menderes Univ, Fac Med, Dept Hematol, TR-09100 Aydin, Turkey.
   [Yenisey, Cigdem] Adnan Menderes Univ, Fac Med, Dept Biochem, TR-09100 Aydin, Turkey.
C3 Adnan Menderes University; Adnan Menderes University; Adnan Menderes
   University; Adnan Menderes University
RP Ozkul, A (corresponding author), Adnan Menderes Univ, Fac Med, Dept Neurol, Aytepe Campus, TR-09100 Aydin, Turkey.
EM ozkulayca@hotmail.com
RI Yenisey, Çiğdem/D-9806-2019; Ozkul, Ayca/ABC-8841-2021
OI Yenisey, Cigdem/0000-0001-7693-641X
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NR 43
TC 10
Z9 14
U1 1
U2 7
PU MAGHIRA & MAAS PUBLICATIONS
PI MUNSBACH
PA MAGHIRA & MAAS S A R L, 6C, RUE GABRIEL LIPPMANN, L-5365 MUNSBACH,
   LUXEMBOURG
SN 0172-780X
EI 2354-4716
J9 NEUROENDOCRINOL LETT
JI Neuroendocrinol. Lett.
PY 2013
VL 34
IS 1
BP 52
EP 57
PG 6
WC Endocrinology & Metabolism; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology
GA AA2AW
UT WOS:000330898500008
PM 23524624
DA 2025-06-11
ER

PT J
AU Garcia, LOR
   Moreira, R
   Silva, MRG
AF Garcia, Luiz Otavio Ribeiro
   Moreira, Ruda
   Silva, Maria-Raquel G.
TI Occupational Stress and Sleep of Military Police Officers From Rio de
   Janeiro, Brazil
SO AMERICAN JOURNAL OF HUMAN BIOLOGY
LA English
DT Article
DE daytime sleepiness; occupational stress; police; shift work; sleep
ID METABOLIC SYNDROME; RISK-FACTORS; WORK; HEALTH; DISTURBANCES;
   ASSOCIATION; VALIDATION; DURATION; BEHAVIOR; TRAVELER
AB Objective: Military Police officers of Rio de Janeiro's State have been considered the most lethal security forces in Brazil, corresponding to 52.35% of deaths in policing actions. The main aim of this study was to identify occupational stress among military police officers in Rio de Janeiro State and its relationship with the psychosocial environment, sleep quality, and daytime sleepiness. Methods: Two hundred and forty-two military policemen, divided into two groups (elite and non-elite), were evaluated occupational stress by the Lipp's Stress Symptoms Inventory (LSSI), daytime sleepiness (DS) by the Epworth Sleepiness Scale and sleep quality (SQ) by the Pitsburgh Sleep Quality Index. Results: Military police officers (entire sample) showed dissatisfaction related to psychological support from the military institution (p = 0.004), about the inefficiency of the judicial system (p < 0.001) and their low popularity towards society (p = 0.009). The group of elite police officers slept significantly less (p = 0.026) and, in general, suffered more from severe daytime sleepiness, had poorer SQ and showed lower levels of occupational stress than their peers. It was possible to identify that stress can be detected, developed, and intensified in military police officers as a result of the environment in which they are exposed and this interferes significantly in sleep and daytime sleepiness (p < 0.05). Conclusion: Through this study, it is hoped that measures can be implemented to enhance the work environment and thereby improve the quality of life for this military population. Furthermore, it is intended to stimulate more comprehensive and longitudinal studies, particularly inclusive of female military personnel.
C1 [Garcia, Luiz Otavio Ribeiro] Univ Fernando Pessoa, Fac Sci & Technol, Porto, Portugal.
   [Garcia, Luiz Otavio Ribeiro] PMERJ Policia Mil Estado Rio De Janeiro, Rio De Janeiro, Brazil.
   [Moreira, Ruda] Univ Estadual Rio de Janeiro UERJ, Rio De Janeiro, Brazil.
   [Silva, Maria-Raquel G.] Univ Fernando Pessoa, CEBIMED, FP BHS, FP I3ID, Porto, Portugal.
   [Silva, Maria-Raquel G.] Univ Fernando Pessoa, Fac Hlth Sci, Porto, Portugal.
   [Silva, Maria-Raquel G.] Portuguese Oncol Inst Porto, CI IPOP IPO Porto Res Ctr, Mol Oncol & Viral Pathol Grp, Porto, Portugal.
   [Silva, Maria-Raquel G.] Univ Coimbra, CIAS Res Ctr Anthropol Hlth Human Biol Hlth & Soc, Coimbra, Portugal.
   [Silva, Maria-Raquel G.] Nova Univ Lisbon, CHRC Comprehens Hlth Res Ctr, Nova Med Sch, Lisbon, Portugal.
   [Silva, Maria-Raquel G.] Sci Comm Gymnast Federat Portugal, Lisbon, Portugal.
   [Silva, Maria-Raquel G.] CENC Sleep Med Ctr, Lisbon, Portugal.
C3 Universidade Fernando Pessoa; Universidade do Estado do Rio de Janeiro;
   Universidade Fernando Pessoa; Universidade Fernando Pessoa; Portuguese
   Institute of Oncology; Universidade de Coimbra; Universidade Nova de
   Lisboa
RP Garcia, LOR (corresponding author), Univ Fernando Pessoa, Fac Sci & Technol, Porto, Portugal.; Garcia, LOR (corresponding author), PMERJ Policia Mil Estado Rio De Janeiro, Rio De Janeiro, Brazil.
EM lorg10@yahoo.com.br
RI SILVA, MARIA/AAU-1111-2020
OI Garcia, Luiz Otavio/0000-0003-1636-3343; Silva, Maria
   Raquel/0000-0001-8170-3119
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NR 54
TC 1
Z9 1
U1 3
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1042-0533
EI 1520-6300
J9 AM J HUM BIOL
JI Am. J. Hum. Biol.
PD JAN
PY 2025
VL 37
IS 1
DI 10.1002/ajhb.24184
EA DEC 2024
PG 11
WC Anthropology; Biology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Anthropology; Life Sciences & Biomedicine - Other Topics
GA S1Z1W
UT WOS:001370047900001
PM 39630574
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Codoñer-Franch, P
   Navarro-Ruiz, A
   Fernández-Ferri, M
   Arilla-Codoñer, A
   Ballester-Asensio, E
   Valls-Bellés, V
AF Codoner-Franch, Pilar
   Navarro-Ruiz, Almudena
   Fernandez-Ferri, Maria
   Arilla-Codoner, Angela
   Ballester-Asensio, Esther
   Valls-Belles, Victoria
TI A matter of fat: insulin resistance and oxidative stress
SO PEDIATRIC DIABETES
LA English
DT Article
DE HOMA-IR; obesity; oxidative stress; type 2 diabetes mellitus
ID OXIDANT/ANTIOXIDANT STATUS; CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME;
   OBESE CHILDREN; TYPE-1; RISK; PREDICTORS; SERUM; ADOLESCENTS; OVERWEIGHT
AB Background Obesity is linked to insulin resistance (IR), which can lead to type 2 diabetes mellitus. Oxidative stress present in early obesity may favor the progression to comorbid conditions. Objective To examine the relationship between oxidative stress biomarkers and the severity of IR in a group of obese children. Methods Forty obese children with a body mass index (BMI) Z-score = 2 were divided into two groups using the median obtained for the homeostasis model assessment of IR (HOMA-IR). Anthropometric parameters (including body fat composition by bioelectrical impedance) and biochemical parameters were assessed. The following biomarkers of oxidative stress were measured: malondialdehyde (MDA), carbonyl groups (CG), reduced glutathione, oxidized low-density lipoprotein, and vitamin E. Comparisons were adjusted for gender and Tanner stage. Results Children with high values of HOMA-IR were more likely to have high body fat percentage and waist circumferences. However, the BMI Z-score did not correlate to the level of IR. Children with higher values of HOMA-IR presented increased levels of markers of oxidative stress in lipids (MDA, p = 0.005) and proteins (CG, p = 0.015). Moreover, MDA increased with increasing levels of HOMA-IR (r = 0.50, p = 0.002), suggesting that lipoperoxidation increases as IR worsens. In a multivariate regression model, only HOMA-IR was predictive of MDA values, irrespective of adiposity parameters and other metabolic risk factors (r2 = 0.22, p = 0.002). Conclusions Oxidative stress increases in obese children according to the severity of IR, which could be linked to the development of comorbidities.
C1 [Codoner-Franch, Pilar; Navarro-Ruiz, Almudena; Fernandez-Ferri, Maria; Ballester-Asensio, Esther] Dr Peset Univ Hosp, Dept Pediat, Valencia 46017, Spain.
   [Codoner-Franch, Pilar; Arilla-Codoner, Angela; Valls-Belles, Victoria] Univ Valencia, Dept Pediat Obstet & Gynecol, Fac Med & Odontol, Valencia, Spain.
C3 University of Valencia
RP Codoñer-Franch, P (corresponding author), Dr Peset Univ Hosp, Dept Pediat, Ave Gaspar Aguilar 90, Valencia 46017, Spain.
EM pilar.codoner@uv.es
RI Codoner-Franch, Pilar/K-9333-2014
OI Codoner-Franch, Pilar/0000-0002-1549-1573
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NR 40
TC 19
Z9 19
U1 0
U2 11
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1399-543X
EI 1399-5448
J9 PEDIATR DIABETES
JI Pediatr. Diabetes
PD AUG
PY 2012
VL 13
IS 5
BP 369
EP 376
DI 10.1111/j.1399-5448.2011.00847.x
PG 8
WC Endocrinology & Metabolism; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Pediatrics
GA 981HJ
UT WOS:000306957300001
PM 22574914
OA gold
DA 2025-06-11
ER

PT J
AU Sudhakaran, G
   Guru, A
   Muthu, BHD
   Murugan, R
   Arshad, A
   Arockiaraj, J
AF Sudhakaran, Gokul
   Guru, Ajay
   Muthu, B. Hari Deva
   Murugan, Raghul
   Arshad, Aziz
   Arockiaraj, Jesu
TI Evidence-based hormonal, mutational, and endocrine-disrupting
   chemical-induced zebrafish as an alternative model to study PCOS
   condition similar to mammalian PCOS model
SO LIFE SCIENCES
LA English
DT Article
DE Polycystic ovarian syndrome; Hyperandrogenism; Zebrafish; Insulin
   resistance; Ovarian dysfunction
ID POLYCYSTIC-OVARY-SYNDROME; ANTI-MULLERIAN HORMONE; GROWTH-FACTOR-I;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; METABOLIC SYNDROME; OOCYTE
   MATURATION; LUTEINIZING-HORMONE; SEX DETERMINATION; ANDROGEN EXCESS
AB Polycystic ovarian syndrome (PCOS) causes swollen ovaries in women at reproductive age due to hormonal disorder with small cysts on the outer edges. The cause of the disorder is still yet to be found. Multiple factors have increased PCOS prevalence, hyperandrogenism, oxidative stress, inflammation, and insulin resistance. Various animal PCOS models have been developed to imitate the pathophysiology of PCOS in humans. Zebrafish is one of the most versatile animal experimental models because of the transparency of the embryos, small size, and rapid growth. The zebrafish similarity to higher vertebrates made it a useful non-mammalian model for PCOS drug testing and screening. This review provides an insight into the usage of zebrafish, a non-mammalian model for PCOS, as an opportunity for evaluating future initiatives in such a research domain.
C1 [Sudhakaran, Gokul; Guru, Ajay; Muthu, B. Hari Deva; Murugan, Raghul; Arockiaraj, Jesu] SRM Inst Sci & Technol, Coll Sci & Humanities, Dept Biotechnol, Chennai 603203, Tamil Nadu, India.
   [Arshad, Aziz] Univ Putra Malaysia, Int Inst Aquaculture & Aquat Sci I AQUAS, Port Dickson 71050, Negeri Sembilan, Malaysia.
   [Arockiaraj, Jesu] Fdn Aquaculture Innovat & Technol Transfer FAITT, Chennai 600097, Tamil Nadu, India.
C3 SRM Institute of Science & Technology Chennai; Universiti Putra Malaysia
RP Arockiaraj, J (corresponding author), SRM Inst Sci & Technol, Coll Sci & Humanities, Dept Biotechnol, Chennai 603203, Tamil Nadu, India.
EM jesuaroa@srmist.edu.in
RI B, Hari Deva Muthu/AAZ-9712-2021; Murugan, Raghul/GSD-8913-2022; Guru,
   Ajay/JFJ-2008-2023; Arockiaraj, Jesu/A-6227-2013; Sudhakaran,
   Gokul/KFR-8453-2024
OI MURUGAN, RAGHUL/0000-0002-0864-4818; , Hari Deva Muthu
   B/0000-0003-4598-5993; Guru, Ajay/0000-0002-8583-9352; Sudhakaran,
   Gokul/0000-0001-6407-0583
FU Universiti Putra Malaysia [LRGS/1/2019/UPM/01/1/4]
FX Acknowledgment The authors extend their sincere appreciation to
   Universiti Putra Malaysia contribution to this research through research
   grant LRGS/1/2019/UPM/01/1/4.
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NR 146
TC 30
Z9 31
U1 3
U2 17
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0024-3205
EI 1879-0631
J9 LIFE SCI
JI Life Sci.
PD FEB 15
PY 2022
VL 291
AR 120276
DI 10.1016/j.lfs.2021.120276
EA JAN 2022
PG 14
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA 0H6LN
UT WOS:000778844200009
PM 34990650
DA 2025-06-11
ER

PT J
AU Venkataraman, C
   Sudha, MR
AF Venkataraman, Chandhini
   Sudha, Mekhala Rethinam
TI A bibliometric analysis of coronary heart disease impacted by work
   stress elements and lifestyle disease
SO JOURNAL OF EVALUATION IN CLINICAL PRACTICE
LA English
DT Review
DE cardiovascular disease; CHD behaviours; healthcare; job strain; job
   strain model
ID SYSTOLIC BLOOD-PRESSURE; TO-VISIT VARIABILITY; JOB STRAIN;
   CARDIOVASCULAR-DISEASE; PSYCHOSOCIAL FACTORS; METABOLIC SYNDROME; RISK;
   ASSOCIATION; METAANALYSIS; STROKE
AB PurposeOne psychosocial risk factor that has drawn attention is work-related stress, although it is still unclear how exactly this risk factor relates to poor health. Prospective observational studies have found a 40%-50% raise in the incidence of coronary heart disease in those who experience chronic stress at work and in their personal lives.Theoretical FrameworkIn the recent decade, there has been a rise in the requirement for firms to gather information on job stress on employees that leads to coronary heart disease. As a result, this study on trends in Coronary Heart Disease induced by Work Stress becomes necessary to examine all of these efforts.Design/MethodologyThis research employs bibliometric analysis and charting to describe the growth and structure of the research field of work-related stress causing coronary heart disease. The field's conceptual framework and research boundaries, the connections between publications and the contributors, key phrases, the latest networks of collaboration, the most prevalent concepts, and the most cited authors are all revealed by our findings.FindingsResearch found that this field has seen a significant increase in research on coronary heart disease in recent years. Because it has been demonstrated that there is a rise in deaths from cardiovascular disease, researchers, academics, and professionals should be made aware of how stress can lead to coronary heart disease.Originality/ValueThe study suggests that workplace health should be a priority for both developed and developing nations, and it must be disseminated in several languages.
C1 [Venkataraman, Chandhini; Sudha, Mekhala Rethinam] Vellore Inst Technol, Business Sch, Chennai 600048, Tamilnadu, India.
C3 Vellore Institute of Technology (VIT); VIT Chennai
RP Sudha, MR (corresponding author), Vellore Inst Technol, Business Sch, Chennai 600048, Tamilnadu, India.
EM mekhala.antony@vit.ac.in
OI R.S, Dr. Mekhala/0000-0003-3864-3426; Venkatraman,
   Chandhini/0000-0002-9232-6790
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NR 64
TC 0
Z9 0
U1 6
U2 11
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1356-1294
EI 1365-2753
J9 J EVAL CLIN PRACT
JI J. Eval. Clin. Pract.
PD MAR
PY 2025
VL 31
IS 2
DI 10.1111/jep.14044
EA AUG 2024
PG 13
WC Health Care Sciences & Services; Medical Informatics; Medicine, General
   & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Health Care Sciences & Services; Medical Informatics; General & Internal
   Medicine
GA 0QD1J
UT WOS:001297235500001
PM 39183494
DA 2025-06-11
ER

PT J
AU Moyers, SA
   Hagger, MS
AF Moyers, Susette A.
   Hagger, Martin S.
TI Physical activity and cortisol regulation: A meta-analysis
SO BIOLOGICAL PSYCHOLOGY
LA English
DT Review
DE Diurnal cortisol slope; Cortisol awakening response; Physical activity;
   Exercise; HPA axis regulation; Health behavior
ID SALIVARY ALPHA-AMYLASE; DANCE MOVEMENT THERAPY; BREAST-CANCER; AWAKENING
   RESPONSE; CHRONIC STRESS; METABOLIC SYNDROME; PERCEIVED STRESS; DIURNAL
   RHYTHMS; HEALTH-BENEFITS; OLDER-ADULTS
AB Physical activity participation is associated with effective stress coping, indicated by decreases in both physiological stress reactivity and perceived stress. Quantifying the effect of physical activity on the diurnal regulation of one key physiological stress indicator, the stress hormone, cortisol, across studies may demonstrate the extent to which physical activity participation is associated with diurnal HPA axis regulation. We meta-analyzed studies examining relations between physical activity participation and indices of HPA axis regulation: the diurnal cortisol slope and the cortisol awakening response. We also examined moderators of the relation. The analysis revealed a small, non-zero negative averaged correlation between physical activity and the diurnal cortisol slope (r = -0.043, 95% CI [-0.080, -0.004]). Examination of sample sociodemographic differences, study design characteristics, cortisol measurement methods, and physical activity variables as moderators revealed few effects on the relation between physical activity and diurnal cortisol slope. We did not observe lower levels of variability in the mean cortisol awakening response at higher levels of physical activity participation, and moderator analyses showed little evidence of reductions in heterogeneity for this effect. We found some evidence of systematic publication bias. Findings suggest higher physical activity is associated with a steeper diurnal cortisol slope. However, the cortisol awakening response did not differ by physical activity level. Future studies testing the physical activity and cortisol regulation association should use standardized physical activity measures, follow guidelines for better quality cortisol sampling collection and analysis, and test relations in large-scale empirical studies to confirm the direction and causality of the effect.
C1 [Moyers, Susette A.] Univ Calif Merced, Dept Psychol Sci, Merced, CA USA.
   [Moyers, Susette A.] Oklahoma State Univ, Ctr Rural Hlth, Ctr Hlth Sci, Tulsa, OK USA.
   [Hagger, Martin S.] Univ Calif Merced, Hlth Sci Res Inst, Merced, CA USA.
   [Hagger, Martin S.] Univ Jyvaskyla, Fac Sport & Hlth Sci, Jyvaskyla, Finland.
   [Hagger, Martin S.] Griffith Univ, Sch Appl Psychol, Nathan, Australia.
   [Moyers, Susette A.] Oklahoma State Univ, Ctr Rural Hlth, Ctr Hlth Sci, 1013 East 66th Pl, Tulsa, OK 74136 USA.
C3 University of California System; University of California Merced;
   Oklahoma State University System; Oklahoma State University Center for
   Health Sciences; University of California System; University of
   California Merced; University of Jyvaskyla; Griffith University;
   Oklahoma State University System; Oklahoma State University Center for
   Health Sciences
RP Moyers, SA (corresponding author), Oklahoma State Univ, Ctr Rural Hlth, Ctr Hlth Sci, 1013 East 66th Pl, Tulsa, OK 74136 USA.
RI Moyers, Susette/AAY-7633-2020; Hagger, Martin/G-5211-2012
OI Moyers, Susette A./0000-0001-6867-2741
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NR 191
TC 16
Z9 16
U1 11
U2 37
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0301-0511
EI 1873-6246
J9 BIOL PSYCHOL
JI Biol. Psychol.
PD APR
PY 2023
VL 179
AR 108548
DI 10.1016/j.biopsycho.2023.108548
EA APR 2023
PG 25
WC Psychology, Biological; Behavioral Sciences; Psychology; Psychology,
   Experimental
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Behavioral Sciences
GA E6MI6
UT WOS:000976657000001
PM 37001634
OA Green Published
DA 2025-06-11
ER

PT J
AU Zheng, JY
   Peng, C
   Ai, YB
   Wang, H
   Xiao, XQ
   Li, JB
AF Zheng, Jinying
   Peng, Chuan
   Ai, Yanbiao
   Wang, Heng
   Xiao, Xiaoqiu
   Li, Jibin
TI Docosahexaenoic Acid Ameliorates Fructose-Induced Hepatic Steatosis
   Involving ER Stress Response in Primary Mouse Hepatocytes
SO NUTRIENTS
LA English
DT Article
DE docosahexaenoic acid; fructose; ER stress; NAFLD
ID FATTY LIVER-DISEASE; ENDOPLASMIC-RETICULUM STRESS; CARNITINE
   PALMITOYLTRANSFERASE-I; INDUCED INSULIN-RESISTANCE; NONALCOHOLIC
   STEATOHEPATITIS; TRANSCRIPTION FACTOR; METABOLIC SYNDROME; ENRICHED
   DIETS; ASIA-PACIFIC; MICE
AB The increase in fructose consumption is considered to be a risk factor for developing nonalcoholic fatty liver disease (NAFLD). We investigated the effects of docosahexaenoic acid (DHA) on hepatic lipid metabolism in fructose-treated primary mouse hepatocytes, and the changes of Endoplasmic reticulum (ER) stress pathways in response to DHA treatment. The hepatocytes were treated with fructose, DHA, fructose plus DHA, tunicamycin (TM) or fructose plus 4-phenylbutyric acid (PBA) for 24 h. Intracellular triglyceride (TG) accumulation was assessed by Oil Red O staining. The mRNA expression levels and protein levels related to lipid metabolism and ER stress response were determined by real-time PCR and Western blot. Fructose treatment led to obvious TG accumulation in primary hepatocytes through increasing expression of fatty acid synthase (FAS) and acetyl-CoA carboxylase (ACC), two key enzymes in hepatic de novo lipogenesis. DHA ameliorates fructose-induced TG accumulation by upregulating the expression of carnitine palmitoyltransferase 1A (CPT-1 alpha) and acyl-CoA oxidase 1 (ACOX1). DHA treatment or pretreatment with the ER stress inhibitor PBA significantly decreased TG accumulation and reduced the expression of glucose-regulated protein 78 (GRP78), total inositol-requiring kinase 1 (IRE1 alpha) and p-IRE1 alpha. The present results suggest that DHA protects against high fructose-induced hepatocellular lipid accumulation. The current findings also suggest that alleviating the ER stress response seems to play a role in the prevention of fructose-induced hepatic steatosis by DHA.
C1 [Zheng, Jinying; Ai, Yanbiao; Li, Jibin] Chongqing Med Univ, Sch Publ Hlth & Management, Res Ctr Med & Social Dev, Innovat Ctr Social Risk Governance Hlth, Chongqing 400016, Peoples R China.
   [Peng, Chuan; Wang, Heng; Xiao, Xiaoqiu] Chongqing Med Univ, Affiliated Hosp 1, Lab Lipid & Glucose Metab, Chongqing 400016, Peoples R China.
C3 Chongqing Medical University; Chongqing Medical University
RP Li, JB (corresponding author), Chongqing Med Univ, Sch Publ Hlth & Management, Res Ctr Med & Social Dev, Innovat Ctr Social Risk Governance Hlth, Chongqing 400016, Peoples R China.; Xiao, XQ (corresponding author), Chongqing Med Univ, Affiliated Hosp 1, Lab Lipid & Glucose Metab, Chongqing 400016, Peoples R China.
EM jinyingzheng1988@163.com; 13527441813@163.com; aiyanbiao1992@163.com;
   hengyy663@163.com; xiaoxq@cqmu.edu.cn; ljb21st@126.com
RI Li, Jibin/ABF-6006-2021; Xiao, Xiaoqiu/K-7672-2019
FU National Natural Science Foundation of China [81270947, 81570763];
   National Key Basic Research Development program [2012CB517505]
FX This study was supported by grants from National Natural Science
   Foundation of China (Grant number: 81270947 and 81570763) and National
   Key Basic Research Development program (Grant number: 2012CB517505) to
   Xiaoqiu Xiao We also thank Richa Goswami for her careful reading and
   editorial corrections for this manuscript.
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NR 44
TC 30
Z9 31
U1 1
U2 18
PU MDPI AG
PI BASEL
PA POSTFACH, CH-4005 BASEL, SWITZERLAND
SN 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JAN
PY 2016
VL 8
IS 1
AR 55
DI 10.3390/nu8010055
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA DK0FY
UT WOS:000374589300052
PM 26805874
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Chen, SC
   Sun, LN
   Gao, HN
   Ren, LP
   Liu, N
   Song, GY
AF Chen, Shuchun
   Sun, Lina
   Gao, Haina
   Ren, Luping
   Liu, Na
   Song, Guangyao
TI Visfatin and oxidative stress influence endothelial progenitor cells in
   obese populations
SO ENDOCRINE RESEARCH
LA English
DT Article
DE Endothelial progenitor cells; obesity; oxidative stress; visfatin
ID CARDIOVASCULAR OUTCOMES; METABOLIC SYNDROME; DYSFUNCTION; ANGIOGENESIS;
   REDUCTION; INSULIN; DISEASE; NUMBER
AB Purpose/Aims of the study: This study sought to study the levels of circulating endothelial progenitor cells (EPCs), serum visfatin, and oxidative stress in obese individuals, and their respective correlations. Materials and methods: The circulating levels of EPCs were measured through detecting CD309 and CD34 by flow cytometry. Serum visfatin concentration was measured by enzyme-linked immunosorbent assay in 31 obese men [obese group: BMI 28.9 +/- 0.86 kg/m(2); age 44.93 +/- 1.78 years (range 40 to 47)] and 30 normal-weight men [control group: BMI 22.7 +/- 1.22 kg/m(2); age 44.03 +/- 1.87 years (range 41 to 47)]. Indexes of oxidative stress were assayed by a colorimetric method. The relationships between circulating EPCs, serum visfatin, and oxidative stress markers were further analyzed by multiple linear regression analysis. Statistical significance was set at p<0.05. Results: The obese group showed higher levels of serum visfatin and a lower level of circulating EPCs compared with controls. Serum superoxide dismutase (SOD) activity, total antioxidant capacity (T-AOC), and glutathione peroxidase (GSH-px) activity were significantly lower in obese subjects than in controls, while levels of serum malondialdehyde (MDA) were significantly higher. Circulating EPCs were positively associated with SOD (beta = 0.306) and LnHOMA-IR (beta = 0.223) and negatively associated with BMI (beta = -0.321), serum visfatin (beta = -0.236), and MDA (beta = -0.293). Conclusions: The quantity of circulating EPCs decreases in obese individuals, along with increased serum visfatin and oxidative stress product. Visfatin and oxidative stress might therefore impact on the circulating EPCs in obese populations.
C1 [Chen, Shuchun; Ren, Luping; Liu, Na; Song, Guangyao] Hebei Res Inst Endocrine & Metab Dis, Shijiazhuang, Hebei, Peoples R China.
   [Chen, Shuchun; Ren, Luping; Liu, Na; Song, Guangyao] Gen Hosp Hebei Prov, Dept Endocrinol, Shijiazhuang, Hebei, Peoples R China.
   [Sun, Lina; Gao, Haina] Hebei Med Univ, Grad Student Inst, Shijiazhuang, Hebei, Peoples R China.
C3 Hebei Medical University
RP Chen, SC (corresponding author), Hebei Gen Hosp, Dept Endocrinol, Shijiazhuang 050051, Hebei, Peoples R China.
EM guang6701@sina.com
RI Sun, Lina/MVV-2976-2025
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NR 32
TC 16
Z9 17
U1 0
U2 4
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 0743-5800
EI 1532-4206
J9 ENDOCR RES
JI Endocr. Res.
PY 2015
VL 40
IS 2
BP 83
EP 87
DI 10.3109/07435800.2014.952016
PG 5
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA CI0CV
UT WOS:000354404300005
PM 25207957
DA 2025-06-11
ER

PT J
AU Gálvez, I
   Torres-Piles, S
   Hinchado, MD
   Alvarez-Barrientos, A
   Torralbo-Jiménez, P
   Guerrero, J
   Martín-Cordero, L
   Ortega, E
AF Galvez, Isabel
   Torres-Piles, Silvia
   Hinchado, Maria D.
   Alvarez-Barrientos, Alberto
   Torralbo-Jimenez, Pilar
   Guerrero, Jorge
   Martin-Cordero, Leticia
   Ortega, Eduardo
TI Immune-Neuroendocrine Dysregulation in Patients with Osteoarthritis: A
   Revision and a Pilot Study
SO ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS
LA English
DT Article
DE Cortisol; Granulocytes; Hsp72; IL-1 beta; IL-6; IL-8; TGF-beta;
   TNF-alpha
ID EXERCISE-INDUCED STIMULATION; INFLAMMATORY CYTOKINES; EXTRACELLULAR
   HSP72; SYNOVIAL-FLUID; METABOLIC SYNDROME; STRESS HORMONES; PROTEINS;
   PLASMA; INTERLEUKIN-6; MEDIATORS
AB Background: Although osteoarthritis (OA)has predominantly been considered a noninflammatory degenerative arthropathy, there is growing evidence that various inflammatory and immunological processes might contribute to the onset, progression, and burden of the disease.
   Objective: The purpose of the present investigation was to study the systemic inflammatory and stress responses and the innate response mediated by neutrophils in OA patients.
   Method: A group of patients diagnosed with primary OA according to the American College of Rheumatology criteria and a control group of age-matched healthy volunteers were enrolled in the study. Serum inflammatory cytokine levels (IL-1 beta, TNF-alpha, IL-8, IL-6, IL-10, and TGF-beta) were evaluated using the Bio-Plex Luminex system. Circulating neuroendocrine-stress biomarkers, such as cortisol and extracellular 72 kDa heat shock protein (eHsp72), were measured by ELISA. The phagocytic and microbicide capacities of circulating neutrophils were evaluated by flow cytometry. All parameters were determined in all volunteers.
   Results: The OA patients showed an inflammatory state accompanied by an altered stress response. This was manifested in high circulating levels of the inflammatory cytokines IL-1 beta, TNF-alpha, IL-8, IL-6, and TGF-beta and the stress protein eHsp72. There were also decreased systemic levels of cortisol, and a reduction in neutrophil phagocytic and microbicidal capacities.
   Conclusion: An immune-neuroendocrine dysregulation affecting both systemic inflammatory and stress mediators and the function of innate immune cells underlies OA. This reflects an altered feedback between the innate/inflammatory and stress responses in this pathology.
C1 [Galvez, Isabel; Hinchado, Maria D.; Ortega, Eduardo] Univ Extremadura, Dept Physiol, Res Grp Immunophysiol, Fac Sci, Avda Elvas S-N, E-06071 Badajoz, Spain.
   [Torres-Piles, Silvia] Univ Extremadura, Dept Med Surg Therapy, Res Grp Immunophysiol, Fac Med, Badajoz, Spain.
   [Alvarez-Barrientos, Alberto; Torralbo-Jimenez, Pilar] Univ Extremadura, Facil Biosci Appl Tech, Badajoz, Spain.
   [Guerrero, Jorge] Univ Extremadura, Dept Nursing, Fac Med, Badajoz, Spain.
   [Martin-Cordero, Leticia] Univ Extremadura, Univ Ctr Plasencia, Dept Nursing, Res Grp Immunophysiol, Plasencia, Spain.
C3 Universidad de Extremadura; Universidad de Extremadura; Universidad de
   Extremadura; Universidad de Extremadura; Universidad de Extremadura
RP Ortega, E (corresponding author), Univ Extremadura, Dept Physiol, Res Grp Immunophysiol, Fac Sci, Avda Elvas S-N, E-06071 Badajoz, Spain.
EM orincon@unex.es
RI piles, silvia/AAO-4112-2020; Galvez, Isabel/LFS-2823-2024; Ortega,
   Eduardo/H-9891-2016; Alvarez-Barrientos, Alberto/L-9299-2014;
   Martin-Cordero, Leticia/H-9711-2015
OI Galvez, Isabel/0000-0002-4294-4507; torres piles, silvia
   teresa/0000-0001-9918-0889; Ortega, Eduardo/0000-0002-7007-7615;
   HINCHADO SANCHEZ-MORO, MARIA DOLORES/0000-0002-9709-4714;
   Alvarez-Barrientos, Alberto/0000-0003-4761-0212; Martin-Cordero,
   Leticia/0000-0002-3651-2265
FU Gobierno de Extremadura-FEDER [GR 15041, GR EE-14-0082-4]; "Formacion
   del Profesorado Universitario (FPU)" from the Ministerio de Educacion,
   Cultura y Deporte, Spain [FPU15/02395]
FX This investigation was partially supported by the Gobierno de
   Extremadura-FEDER (GR 15041 and GR EE-14-0082-4). Galvez I is recipient
   of a "Formacion del Profesorado Universitario (FPU)" pre-doctoral
   contract (FPU15/02395) from the Ministerio de Educacion, Cultura y
   Deporte, Spain. Funding sources had no role in the study design,
   collection, analysis, and interpretation of the data or the decision to
   submit the manuscript for publication.
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NR 43
TC 22
Z9 23
U1 0
U2 4
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1871-5303
EI 2212-3873
J9 ENDOCR METAB IMMUNE
JI Endocr. Metab. Immune Disord.-Drug Targets
PY 2017
VL 17
IS 1
BP 78
EP 85
DI 10.2174/1871530317666170320113613
PG 8
WC Endocrinology & Metabolism; Immunology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Immunology; Pharmacology & Pharmacy
GA EZ8QZ
UT WOS:000404993200010
PM 28322172
DA 2025-06-11
ER

PT J
AU Hao, LY
   Li, SH
   Chen, G
   Hu, XY
AF Hao, Liyuan
   Li, Shenghao
   Chen, Guo
   Hu, Xiaoyu
TI Regulation of UCP2 in nonalcoholic fatty liver disease: From mechanisms
   to natural product
SO CHEMICAL BIOLOGY & DRUG DESIGN
LA English
DT Review
DE NAFLD; natural products; UCP2
ID MITOCHONDRIAL UNCOUPLING PROTEIN-2; OXIDATIVE STRESS; ACID OXIDATION;
   UP-REGULATION; PPAR-ALPHA; EXPRESSION; OBESITY; INJURY; DEFICIENT; MICE
AB Nonalcoholic fatty liver disease (NAFLD) is a chronic liver disease associated with lipid deposition in liver cells and/or subsequent inflammation, excluding other known causes. NAFLD is a subset of metabolic syndrome that ranges from simple steatohepatitis (NASH), fibrosis to cirrhosis and hepatocellular carcinoma (HCC). At present, the pathogenesis of NAFLD remains unclear. Among the many factors that shape these transitions, uncoupling protein 2 (UCP2) may be involved in every stage of the disease. UCP2 is a carrier protein that responds to fatty acids (FAs) in mitochondrial intima and has a wide tissue distribution. However, the biological function of UCP2 has not been fully elucidated, and most of our current knowledge comes from cell and animal experiments. These data suggest that UCP2 plays a role in lipid metabolism, oxidative stress, apoptosis, and even cancer. In this review, we summarize the structure, distribution, and biological function of UCP2 and its role in the progression of NAFLD, as well as natural products targeting UCP2 to improve NAFLD.
C1 [Hao, Liyuan; Li, Shenghao; Chen, Guo; Hu, Xiaoyu] Hosp Chengdu Univ Tradit Chinese Med, Chengdu, Peoples R China.
   [Hao, Liyuan; Li, Shenghao] Chengdu Univ Tradit Chinese Med, Chengdu, Peoples R China.
   [Hu, Xiaoyu] Hosp Chengdu Univ Tradit Chinese Med, 39 Shi er qiao Rd, Chengdu 610072, Sichuan, Peoples R China.
C3 Chengdu University of Traditional Chinese Medicine; Chengdu University
   of Traditional Chinese Medicine; Chengdu University of Traditional
   Chinese Medicine
RP Hu, XY (corresponding author), Hosp Chengdu Univ Tradit Chinese Med, 39 Shi er qiao Rd, Chengdu 610072, Sichuan, Peoples R China.
EM xiaoyuhu202206@163.com
FU National science and Technology major projects of the 13th Five Year
   Plan
FX Not applicable.
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NR 99
TC 0
Z9 0
U1 1
U2 9
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1747-0277
EI 1747-0285
J9 CHEM BIOL DRUG DES
JI Chem. Biol. Drug Des.
PD FEB
PY 2024
VL 103
IS 2
AR e14461
DI 10.1111/cbdd.14461
PG 11
WC Biochemistry & Molecular Biology; Chemistry, Medicinal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
GA FQ1V8
UT WOS:001147232700001
OA hybrid
DA 2025-06-11
ER

PT J
AU Shin, D
   Choi, J
   Lee, HY
AF Shin, Donghun
   Choi, JungMin
   Lee, Hae-Young
TI Suboptimal control status of young hypertensive population
SO CLINICAL HYPERTENSION
LA English
DT Review
DE Hypertension; Young adults; Blood pressure
ID BLOOD-PRESSURE; CARDIOVASCULAR-DISEASE; ANTIHYPERTENSIVE MEDICATION;
   ADULTS; RISK; PREVALENCE; GUIDELINES; ADHERENCE; AWARENESS; MANAGEMENT
AB The prevalence of hypertension (HT) among young adults aged 18 to 39 years is estimated to be 3.7% to 8.6% worldwide. Although the prevalence of HT in young adults is lower than that of the overall population, those with HT are at substantially increased risk of cardiovascular events compared to those without HT. HT in young adults should be taken with even more caution as longer exposure to higher blood pressure leads to a higher lifetime risk of HT-mediated organ damage. However, young patients with HT show low awareness of HT compared to older patients. Also, they are more prone to show low treatment adherence despite the good efficacy of the treatment. Other risk factors that hinder HT control among young adults include alcohol intake, smoking, low physical activity, emotional stress, job stress, metabolic syndrome, and obesity. This review aimed to illustrate the suboptimal control status of the young hypertensive population and to propose strategies for improvement.
C1 [Shin, Donghun] Seoul Natl Univ, Coll Med, Seoul, South Korea.
   [Choi, JungMin; Lee, Hae-Young] Seoul Natl Univ Hosp, Dept Internal Med, Div Cardiol, Seoul, South Korea.
   [Lee, Hae-Young] Seoul Natl Univ, Coll Med, Dept Internal Med, Seoul, South Korea.
C3 Seoul National University (SNU); Seoul National University (SNU); Seoul
   National University Hospital; Seoul National University (SNU)
RP Lee, HY (corresponding author), Seoul Natl Univ Hosp, Dept Internal Med, Div Cardiol, Seoul, South Korea.; Lee, HY (corresponding author), Seoul Natl Univ, Coll Med, Dept Internal Med, Seoul, South Korea.
EM hylee612@snu.ac.kr
RI Choi, Jah/AAA-4835-2022; Lee, Hye-Young/JEP-8044-2023
OI Lee, Hae-Young/0000-0002-9521-4102
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NR 57
TC 9
Z9 10
U1 0
U2 1
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
EI 2056-5909
J9 CLIN HYPERTENS
JI Clin. Hypertens.
PD MAY 1
PY 2023
VL 29
IS 1
AR 13
DI 10.1186/s40885-023-00237-6
PG 9
WC Peripheral Vascular Disease
WE Emerging Sources Citation Index (ESCI)
SC Cardiovascular System & Cardiology
GA E9HF6
UT WOS:000978560000001
PM 37122032
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Haczeyni, F
   Bell-Anderson, KS
   Farrell, GC
AF Haczeyni, F.
   Bell-Anderson, K. S.
   Farrell, G. C.
TI Causes and mechanisms of adipocyte enlargement and adipose expansion
SO OBESITY REVIEWS
LA English
DT Article
DE Adipose tissue; cellular hypertrophy; hyperplasia; insulin resistance
ID METABOLICALLY HEALTHY OBESITY; DE-NOVO LIPOGENESIS; ACTIVATED
   RECEPTOR-GAMMA; FARNESOID X RECEPTOR; FATTY LIVER-DISEASE;
   INSULIN-RESISTANCE; LIPID DROPLETS; CELL-SIZE; TISSUE DEVELOPMENT;
   ENERGY-METABOLISM
AB Adipose tissue plays a significant role in whole body energy homeostasis. Obesity-associated diabetes, fatty liver and metabolic syndrome are closely linked to adipose stress and dysfunction. Genetic predisposition, overeating and physical inactivity influence the expansion of adipose tissues. Under conditions of constant energy surplus, adipocytes become hypertrophic and adipose tissues undergo hyperplasia so as to increase their lipid storage capacity, thereby keeping circulating blood glucose and fatty acids below toxic levels. Nonetheless, adipocytes have a saturation point where they lose capacity to store more lipids. At this stage, when adipocytes are fully lipid-engorged, they express stress signals. Adipose depots (particularly visceral compartments) from obese individuals with a severe metabolic phenotype are characterized by the high proportion of hypertrophic adipocytes. This review focuses on the mechanisms of adipocyte enlargement in relation to adipose fatty acid and cholesterol metabolism, and considers how this may be related to adipose dysfunction.
C1 [Haczeyni, F.; Farrell, G. C.] Australian Natl Univ, Sch Med, Canberra Hosp, Liver Res Grp, Canberra, ACT, Australia.
   [Bell-Anderson, K. S.] Univ Sydney, Sch Life & Environm Sci, Charles Perkins Ctr, Sydney, NSW, Australia.
C3 Australian National University; Canberra Hospital; University of Sydney
RP Farrell, GC (corresponding author), Australian Natl Univ, Med Sch, Canberra Hosp, Level 5,Bldg 10,Yamba Dr, Canberra, ACT 2605, Australia.
EM geoff.farrell@anu.edu.au
RI Bell-Anderson, Kim/A-5588-2009
FU National Health and Medical Research Council (NHMRC) project [1044288,
   102818]
FX National Health and Medical Research Council (NHMRC) project grants:
   1044288 and 102818.
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NR 175
TC 141
Z9 158
U1 0
U2 28
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1467-7881
EI 1467-789X
J9 OBES REV
JI Obes. Rev.
PD MAR
PY 2018
VL 19
IS 3
BP 406
EP 420
DI 10.1111/obr.12646
PG 15
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA FV0XS
UT WOS:000424285400010
PM 29243339
DA 2025-06-11
ER

PT J
AU Campagna, R
   Cecati, M
   Vignini, A
AF Campagna, Roberto
   Cecati, Monia
   Vignini, Arianna
TI The Multifaceted Role of the Polyphenol Curcumin: A Focus on Type 2
   Diabetes Mellitus
SO CURRENT DIABETES REVIEWS
LA English
DT Review
DE Type 2 diabetes mellitus; curcumin; curcuminoids; antioxidant activity;
   molecular mechanisms; oxidative stress
ID ACTIVATED SIGNALING PATHWAYS; I CLINICAL-TRIAL; OXIDATIVE STRESS;
   DOUBLE-BLIND; NANO-CURCUMIN; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   BETA-CELLS; LIFE-STYLE; PLACEBO
AB Type 2 Diabetes Mellitus (T2DM) is a chronic metabolic disorder characterized by chronic hyperglycemia, which often co-exists with other metabolic impairments. This condition can damage various tissues and organs, resulting in the development of severe complications, both microvascular, such as retinopathy, nephropathy, and neuropathy, and macrovascular, responsible for an increased risk of cardiovascular diseases. Curcumin is the main bioactive molecule found in the rhizomes of turmeric. Many studies have reported curcumin to exhibit antioxidant, anti-inflammatory, anti-infectious, and anti-cancer properties; thus, there is an increasing interest in exploiting these properties in order to prevent the rise or the progression of T2DM, as well as its possible associated conditions. In this review, we have presented the current state-of-art regarding the clinical trials that have involved curcumin administration and analyzed the possible mechanisms by which curcumin might exert the beneficial effects observed in literature.
C1 [Campagna, Roberto; Vignini, Arianna] Polytech Univ Marche, Dept Clin Sci, Ancona, Italy.
   [Cecati, Monia] IRCCS INRCA, Adv Technol Ctr Aging Res, Sci Direct, Ancona, Italy.
C3 Marche Polytechnic University; IRCCS INRCA
RP Vignini, A (corresponding author), Polytech Univ Marche, Dept Clin Sci, Ancona, Italy.
EM a.vignini@univpm.it
RI Campagna, Roberto/GPT-4507-2022
OI CAMPAGNA, ROBERTO/0000-0003-2607-2734; Cecati, Monia/0000-0003-4947-5157
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NR 150
TC 1
Z9 1
U1 3
U2 3
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1573-3998
EI 1875-6417
J9 CURR DIABETES REV
JI Curr. Diabetes Reviews
PY 2025
VL 21
IS 8
AR e15733998313402
DI 10.2174/0115733998313402240726080637
PG 14
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA Z4B6P
UT WOS:001438386000002
PM 39620334
DA 2025-06-11
ER

PT J
AU Simao, VA
   Ferder, L
   Manucha, W
   Chuffa, LGA
AF Simao, Vinicius Augusto
   Ferder, Leon
   Manucha, Walter
   Chuffa, Luiz Gustavo A.
TI Epigenetic Mechanisms Involved in Inflammaging-Associated Hypertension
SO CURRENT HYPERTENSION REPORTS
LA English
DT Review
DE Vascular inflammation; Inflammaging; Hypertension; Epigenetics;
   Inflammasome; Elderly
ID SMOOTH-MUSCLE-CELLS; INDUCED PHENOTYPIC TRANSFORMATION; PULMONARY-ARTERY
   HYPERTENSION; LONG NONCODING RNAS; ANGIOTENSIN-II; OXIDATIVE STRESS; DNA
   METHYLATION; METABOLIC SYNDROME; BLOOD-PRESSURE; CARDIOVASCULAR-DISEASE
AB Purpose of Review This review summarizes the involvement of inflammaging in vascular damage with focus on the epigenetic mechanisms by which inflammaging-induced hypertension is triggered. Recent Findings Inflammaging in hypertension is a complex condition associated with the production of inflammatory mediators by the immune cells, enhancement of oxidative stress, and tissue remodeling in vascular smooth muscle cells and endothelial cells. Cellular processes are numerous, including inflammasome assembly and cell senescence which may involve mitochondrial dysfunction, autophagy, DNA damage response, dysbiosis, and many others. More recently, a series of noncoding RNAs, mainly microRNAs, have been described as possessing epigenetic actions on the regulation of inflammasome-related hypertension, emerging as a promising therapeutic strategy. Although there are a variety of pharmacological agents that effectively regulate inflammaging-related hypertension, a deeper understanding of the epigenetic events behind the control of vessel deterioration is needed for the treatment or even to prevent the disease onset.
C1 [Simao, Vinicius Augusto; Chuffa, Luiz Gustavo A.] UNESP Sao Paulo State Univ, Inst Biosci, Dept Struct & Funct Biol, POB 18618 689,Zip Code 510, Botucatu, SP, Brazil.
   [Ferder, Leon] Univ Maimonides, Buenos Aires, DF, Argentina.
   [Manucha, Walter] Univ Nacl Cuyo, Fac Ciencias Med, Dept Patol, Lab Farmacol Expt Basica & Traslac Area Farmacol, Mendoza, Argentina.
   [Manucha, Walter] Consejo Nacl Invest Cient & Tecnol IMBECU C, Inst Med & Biol Expt Cuyo, Mendoza, Argentina.
C3 Universidade Estadual Paulista; University Nacional Cuyo Mendoza
RP Chuffa, LGA (corresponding author), UNESP Sao Paulo State Univ, Inst Biosci, Dept Struct & Funct Biol, POB 18618 689,Zip Code 510, Botucatu, SP, Brazil.
EM luiz-gustavo.chuffa@unesp.br
RI Simão, Vinicius/AAD-5469-2021; Simao, Vinicius/Y-6827-2018; Chuffa, Luiz
   Gustavo/A-4085-2010
OI Manucha, Walter/0000-0002-2279-7626; Simao,
   Vinicius/0000-0002-3915-2795; Chuffa, Luiz Gustavo/0000-0002-0199-3396
FU Research and Technology Council of Cuyo University (SECyT), Mendoza,
   Argentina; National Agency for the Promotion of Research, Technological
   Development and Innovation ANPCyT FONCyT [PICT 2020-Serie A-4000]
FX This work was supported by grants from the Research and Technology
   Council of Cuyo University (SECyT), Mendoza, Argentina, and from the
   National Agency for the Promotion of Research, Technological Development
   and Innovation ANPCyT FONCyT (Grant no. PICT 2020-Serie A-4000).
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NR 153
TC 8
Z9 8
U1 3
U2 8
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1522-6417
EI 1534-3111
J9 CURR HYPERTENS REP
JI Curr. Hypertens. Rep.
PD NOV
PY 2022
VL 24
IS 11
BP 547
EP 562
DI 10.1007/s11906-022-01214-4
EA JUL 2022
PG 16
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 5I4CU
UT WOS:000821721800001
PM 35796869
DA 2025-06-11
ER

PT J
AU Hemmings, SMJ
   Swart, P
   Womersely, JS
   Ovenden, ES
   van den Heuvel, LL
   Mcgregor, NW
   Meier, S
   Bardien, S
   Abrahams, S
   Tromp, G
   Emsley, R
   Carr, J
   Seedat, S
AF Hemmings, Sian M. J.
   Swart, Patricia
   Womersely, Jacqueline S.
   Ovenden, Ellen S.
   van den Heuvel, Leigh L.
   Mcgregor, Nathaniel W.
   Meier, Stuart
   Bardien, Soraya
   Abrahams, Shameemah
   Tromp, Gerard
   Emsley, Robin
   Carr, Jonathan
   Seedat, Soraya
TI RNA-seq analysis of gene expression profiles in posttraumatic stress
   disorder, Parkinson's disease and schizophrenia identifies roles for
   common and distinct biological pathways
SO DISCOVER MENTAL HEALTH
LA English
DT Article
ID GENOME-WIDE ASSOCIATION; PERIPHERAL-BLOOD; UBIQUITIN PROTEASOME;
   PSYCHOTIC FEATURES; METABOLIC SYNDROME; CLUSTER-ANALYSIS; PROTEIN S3;
   RISK LOCI; METAANALYSIS; TRANSCRIPTOME
AB Evidence suggests that shared pathophysiological mechanisms in neuropsychiatric disorders (NPDs) may contribute to risk and resilience. We used single-gene and network-level transcriptomic approaches to investigate shared and disorder-specific processes underlying posttraumatic stress disorder (PTSD), Parkinson's disease (PD) and schizophrenia in a South African sample. RNA-seq was performed on blood obtained from cases and controls from each cohort. Gene expression and weighted gene correlation network analyses (WGCNA) were performed using DESeq2 and CEMiTool, respectively. Significant differences in gene expression were limited to the PTSD cohort. However, WGCNA implicated, amongst others, ribosomal expression, inflammation and ubiquitination as key players in the NPDs under investigation. Differential expression in ribosomal-related pathways was observed in the PTSD and PD cohorts, and focal adhesion and extracellular matrix pathways were implicated in PD and schizophrenia. We propose that, despite different phenotypic presentations, core transdiagnostic mechanisms may play important roles in the molecular aetiology of NPDs.
C1 [Hemmings, Sian M. J.; Swart, Patricia; Womersely, Jacqueline S.; van den Heuvel, Leigh L.; Mcgregor, Nathaniel W.; Emsley, Robin; Seedat, Soraya] Stellenbosch Univ, Fac Med & Hlth Sci, Dept Psychiat, POB 241, Cape Town 8000, South Africa.
   [Hemmings, Sian M. J.; Swart, Patricia; Womersely, Jacqueline S.; van den Heuvel, Leigh L.; Bardien, Soraya; Abrahams, Shameemah; Seedat, Soraya] Stellenbosch Univ, Stellenbosch Univ Genom Brain Disorders Res Unit, South African Med Res Council, Cape Town, South Africa.
   [Ovenden, Ellen S.; Mcgregor, Nathaniel W.] Stellenbosch Univ, Dept Genet, Syst Genet Working Grp, Stellenbosch, South Africa.
   [Meier, Stuart; Bardien, Soraya; Abrahams, Shameemah; Tromp, Gerard] Stellenbosch Univ, Dept Biomed Sci, Div Mol Biol & Human Genet, Cape Town, South Africa.
   [Meier, Stuart; Tromp, Gerard] Stellenbosch Univ, DSI NRF Ctr Excellence Biomed TB Res, Cape Town, South Africa.
   [Meier, Stuart; Tromp, Gerard] Stellenbosch Univ, South African Med Res Council, Ctr TB Res, Cape Town, South Africa.
   [Meier, Stuart; Tromp, Gerard] Stellenbosch Univ, South African TB Bioinformat Initiat, Cape Town, South Africa.
   [Tromp, Gerard] Stellenbosch Univ, Ctr Bioinformat & Computat Biol, Stellenbosch, South Africa.
   [Carr, Jonathan] Stellenbosch Univ, Fac Med & Hlth Sci, Dept Med, Div Neurol, Cape Town, South Africa.
C3 Stellenbosch University; Stellenbosch University; South African Medical
   Research Council; Stellenbosch University; Stellenbosch University;
   Stellenbosch University; South African Medical Research Council;
   Stellenbosch University; Stellenbosch University; Stellenbosch
   University; Stellenbosch University
RP Hemmings, SMJ (corresponding author), Stellenbosch Univ, Fac Med & Hlth Sci, Dept Psychiat, POB 241, Cape Town 8000, South Africa.; Hemmings, SMJ (corresponding author), Stellenbosch Univ, Stellenbosch Univ Genom Brain Disorders Res Unit, South African Med Res Council, Cape Town, South Africa.
EM smjh@sun.ac.za
RI Bardien, Soraya/AAJ-9003-2020; Carr, Jonathan/JSK-2055-2023; van den
   Heuvel, Leigh/AGV-5481-2022; Hemmings, Sian/ABF-9676-2022; Tromp,
   Gerard/B-2677-2017; McGregor, Nathaniel/H-7761-2015
OI Tromp, Gerard/0000-0002-7761-0806; meier, stuart/0000-0003-4559-9718;
   Womersley, Jacqueline/0000-0001-9731-4505; van den Heuvel,
   Leigh/0000-0003-3884-4754; Swart, Patricia/0000-0001-8249-6895;
   Hemmings, Sian/0000-0001-8461-1017; McGregor,
   Nathaniel/0000-0001-7195-4993
FU South African Medical Research Council from the South African National
   Treasury [MRC-RFA-IFSP-01-2013]; South African Medical Research Council
   from the South African National Treasury
FX Research reported in this publication was supported by the South African
   Medical Research Council for the "Shared Roots" Flagship Project, Grant
   no. MRC-RFA-IFSP-01-2013/SHARED ROOTS" through funding received from the
   South African National Treasury under its Economic Competitiveness and
   Support Package. Its contents are solely the responsibility of the
   authors and do not necessarily represent the official views of the South
   African Medical Research Council. The work by Leigh van den Heuvel
   reported herein was made possible through funding by the South African
   Medical Research Council through its Division of Research Capacity
   Development under the SAMRC Clinician Researcher (M.D PhD) Scholarship
   Programme from funding received from the South African National
   Treasury. The content hereof is the sole responsibility of the authors
   and do not necessarily represent the official views of the SAMRC or the
   funders.
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NR 146
TC 7
Z9 7
U1 0
U2 0
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
EI 2731-4383
J9 DISCOV MENT HEALTH
JI Discov. Ment. Heatlh
PD MAR 3
PY 2022
VL 2
IS 1
AR 6
DI 10.1007/s44192-022-00009-y
PG 18
WC Psychiatry
WE Emerging Sources Citation Index (ESCI)
SC Psychiatry
GA H1D7A
UT WOS:001320921100001
PM 37861850
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Anwardeen, N
   Naja, K
   Elrayess, MA
AF Anwardeen, Najeha
   Naja, Khaled
   Elrayess, Mohamed A.
TI Association between antioxidant metabolites and N-terminal fragment
   brain natriuretic peptides in insulin-resistant individuals
SO CARDIOVASCULAR ENDOCRINOLOGY & METABOLISM
LA English
DT Article
DE antioxidant; insulin resistance; metabolomics; NT-proBNP
ID METHIONINE SULFOXIDE REDUCTASE; OXIDATIVE STRESS; HEART-FAILURE;
   TRANSFERASE; ANEMIA; FUTURE
AB ObjectivesOxidative stress plays a pivotal role in the development of metabolic syndrome, including heart failure and insulin resistance. The N-terminal fragment of brain natriuretic peptide (NT-proBNP) has been associated with heightened oxidative stress in heart failure patients. Yet, its correlation with insulin resistance remains poorly understood. Our objective is to investigate the association between oxidative stress markers and NT-proBNP levels in insulin-resistant individuals.MethodsIn this cross-sectional study involving 393 participants from the Qatar Biobank, clinical and metabolic data were collected, and the association between NT-proBNP and 72 oxidative stress metabolites was compared between insulin-sensitive and insulin-resistant individuals.ResultsOur results showed significantly lower NT-proBNP levels in insulin-resistant individuals (median = 17 pg/ml; interquartile range = 10.3-29) when compared to their insulin-sensitive counterparts (median = 31 pg/ml; interquartile range = 19-57). Moreover, we revealed notable associations between NT-proBNP levels and antioxidant metabolic pathways, particularly those related to glutathione metabolism, in insulin-resistant, but not insulin-sensitive individuals.ConclusionThe significant decrease in NT-proBNP observed in individuals with insulin resistance may be attributed to a direct or indirect enhancement in glutathione production, which is regarded as a compensatory mechanism against oxidative stress. This study could advance our understanding of the interplay between oxidative stress during insulin resistance and cardiovascular risk, which could lead to novel therapeutic approaches for managing cardiovascular diseases. Further investigations are needed to assess the practical utility of these potential metabolites and understand the causal nature of their association with NT-proBNP in the etiology of insulin resistance.
C1 [Anwardeen, Najeha; Naja, Khaled; Elrayess, Mohamed A.] Qatar Univ, Biomed Res Ctr, POB 2713, Doha, Qatar.
   [Elrayess, Mohamed A.] Qatar Univ, QU Hlth, Doha, Qatar.
C3 Qatar University; Qatar University
RP Elrayess, MA (corresponding author), Qatar Univ, Biomed Res Ctr, POB 2713, Doha, Qatar.
EM m.elrayess@qu.edu.qa
RI Elrayess, Mohamed/LVA-1229-2024; Naja, Khaled/KDM-6485-2024
OI Naja, Khaled/0000-0001-9259-3082
FU Qatar National Research Fund (QNRF) [NPRP13S-1230-190008]
FX The authors would like to acknowledge Qatar Biobank for providing the
   data.This research was funded by Qatar National Research
   Fund (QNRF), grant number NPRP13S-1230-190008. K.N. wrote the article,
   N.A. wrote the article and supported the statistical analysis, and
   M.A.E. supervised the work. All authors have read and agreed to the
   published version of the manuscript
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NR 55
TC 1
Z9 1
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 2574-0954
J9 CARDIOVASC ENDOCR ME
JI Cardiovasc. Endocrinol. Metab.
PD JUN
PY 2024
VL 13
IS 2
AR e0303
DI 10.1097/XCE.0000000000000303
PG 9
WC Cardiac & Cardiovascular Systems
WE Emerging Sources Citation Index (ESCI)
SC Cardiovascular System & Cardiology
GA M5J3R
UT WOS:001357894600001
PM 38706534
OA gold
DA 2025-06-11
ER

PT J
AU Xiang, Y
   Wang, H
   Ding, HM
   Xu, TY
   Liu, X
   Huang, ZC
   Wu, HH
   Ge, HS
AF Xiang, Yu
   Wang, Hua
   Ding, Huimin
   Xu, Tianyue
   Liu, Xiu
   Huang, Zichao
   Wu, Honghui
   Ge, Hongshan
TI Hyperandrogenism drives ovarian inflammation and pyroptosis: A possible
   pathogenesis of PCOS follicular dysplasia
SO INTERNATIONAL IMMUNOPHARMACOLOGY
LA English
DT Article
DE Polycystic ovary syndrome; Hyperandrogenism; Pyroptosis; Inflammatory;
   Endoplasmic reticulum stress
ID ENDOPLASMIC-RETICULUM STRESS; GRADE CHRONIC INFLAMMATION; CELL-DEATH;
   GRANULOSA-CELLS; METABOLIC SYNDROME; ANDROGEN EXCESS; WOMEN; DEFINITION;
   EXPRESSION; AUTOPHAGY
AB Hyperandrogenemia and persistent chronic inflammation, two main striking features of polycystic ovary syndrome (PCOS), have been proven involved in follicular dysgenesis in PCOS. However, the association between hyperandrogenism and inflammation activation in PCOS is not fully understood. Excess testosterone(T) induces inflammation and pyroptosis activation in a mouse model of PCOS, leading to ovarian dysfunction and fibrosis. Excessive endoplasmic reticulum (ER) stress is present in ovarian granulosa cells (GCs), testosterone induced PCOS mouse and cellular models. This study found higher levels of interleukin (IL)-1 beta, IL-8, IL-17, and IL-18 in the follicular fluid of PCOS patients with hyperandrogenemia undergoing IVF treatment. In addition, pyroptosis in GCs was demonstrated, which was significantly elevated in PCOS patients. To clarify the association of hyperandrogenism, inflammation, and pyroptosis activation in PCOS, dehydroepiandrosterone(DHEA)-treated mouse PCOS model and T-treated KGN cell line were explored for PCOS mechanism. Markers of inflammatory activation and pyroptosis were significantly increased after DHEA treatment in mice and T treatment in KGN cells. In addition, ER stress sensor proteins were increased simultaneously. However, suppression of inflammation by genipin(GP) led to decreased pyroptosis in KGN cells but no variation in ER stress sensor proteins. In contrast, when treated with tauroursodeoxycholic acid(TUDCA) to attenuate ER stress, the markers of inflammatory factors were significantly reduced, accompanied by a reduction in pyroptosis. Our results suggest that persistent hyperandrogenemia of PCOS promotes local inflammatory activation of the ovary, and the imbalanced inflammatory microenvironment leads to pyroptosis of GCs, which is mediated by ER stress activation.
C1 [Xiang, Yu; Wang, Hua; Ding, Huimin; Xu, Tianyue; Liu, Xiu; Huang, Zichao; Wu, Honghui; Ge, Hongshan] Nanjing Med Univ, Affiliated Taizhou Peoples Hosp, Reprod Med Ctr, Taizhou, Peoples R China.
   [Xiang, Yu; Ding, Huimin; Xu, Tianyue; Huang, Zichao; Ge, Hongshan] Nanjing Univ Chinese Med, Grad Sch, Nanjing, Peoples R China.
   [Wang, Hua] Nanjing Univ Chinese Med, Clin Med Coll 3, Nanjing, Peoples R China.
   [Liu, Xiu; Wu, Honghui; Ge, Hongshan] Dalian Med Univ, Grad Sch, Dalian, Liaoning, Peoples R China.
   [Ge, Hongshan] Nanjing Univ Chinese Med, Taizhou Peoples Hosp, Assisted Reprod Unit, 399 Hailing South Rd, Taizhou, Peoples R China.
C3 Nanjing Medical University; Nanjing University of Chinese Medicine;
   Nanjing University of Chinese Medicine; Dalian Medical University;
   Nanjing University of Chinese Medicine
RP Ge, HS (corresponding author), Nanjing Univ Chinese Med, Taizhou Peoples Hosp, Assisted Reprod Unit, 399 Hailing South Rd, Taizhou, Peoples R China.
EM hongshange@njmu.edu.cn
RI Wu, Honghui/MGV-0677-2025; xiang, yu/KOC-9302-2024
OI Ge, Hongshan/0000-0001-9556-5490
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NR 71
TC 35
Z9 37
U1 2
U2 35
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1567-5769
EI 1878-1705
J9 INT IMMUNOPHARMACOL
JI Int. Immunopharmacol.
PD DEC
PY 2023
VL 125
AR 111141
DI 10.1016/j.intimp.2023.111141
EA OCT 2023
PN A
PG 14
WC Immunology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Pharmacology & Pharmacy
GA Y7SP9
UT WOS:001107225400001
PM 37918087
OA hybrid
DA 2025-06-11
ER

PT J
AU Nikolic, A
   Fahlbusch, P
   Wahlers, N
   Riffelmann, NK
   Jacob, S
   Hartwig, S
   Kettel, U
   Dille, M
   Al-Hasani, H
   Kotzka, J
   Knebel, B
AF Nikolic, Aleksandra
   Fahlbusch, Pia
   Wahlers, Natalie
   Riffelmann, Nele-Kathrien
   Jacob, Sylvia
   Hartwig, Sonja
   Kettel, Ulrike
   Dille, Matthias
   Al-Hasani, Hadi
   Kotzka, Joerg
   Knebel, Birgit
TI Chronic stress targets mitochondrial respiratory efficiency in the
   skeletal muscle of C57BL/6 mice
SO CELLULAR AND MOLECULAR LIFE SCIENCES
LA English
DT Article
DE Metabolic adaptation; Proteome; Transcriptome; Methylome; Enriched
   mitochondria; Mitochondrial thermodynamic efficiency (n-opt)
ID OBESITY; DISORDER; BROWN; DIET; ASSOCIATION; PEROXISOMES; DYSFUNCTION;
   DYNAMICS; FISSION; ORGAN
AB Episodes of chronic stress can result in psychic disorders like post-traumatic stress disorder, but also promote the development of metabolic syndrome and type 2 diabetes. We hypothesize that muscle, as main regulator of whole-body energy expenditure, is a central target of acute and adaptive molecular effects of stress in this context. Here, we investigate the immediate effect of a stress period on energy metabolism in Musculus gastrocnemius in our established C57BL/6 chronic variable stress (Cvs) mouse model. Cvs decreased lean body mass despite increased energy intake, reduced circadian energy expenditure (EE), and substrate utilization. Cvs altered the proteome of metabolic components but not of the oxidative phosphorylation system (OXPHOS), or other mitochondrial structural components. Functionally, Cvs impaired the electron transport chain (ETC) capacity of complex I and complex II, and reduces respiratory capacity of the ETC from complex I to ATP synthase. Complex I-OXPHOS correlated to diurnal EE and complex II-maximal uncoupled respiration correlated to diurnal and reduced nocturnal EE. Bioenergetics assessment revealed higher optimal thermodynamic efficiencies (n-opt) of mitochondria via complex II after Cvs. Interestingly, transcriptome and methylome were unaffected by Cvs, thus excluding major contributions to supposed metabolic adaptation processes. In summary, the preclinical Cvs model shows that metabolic pressure by Cvs is initially compensated by adaptation of mitochondria function associated with high thermodynamic efficiency and decreased EE to manage the energy balance. This counter-regulation of mitochondrial complex II may be the driving force to longitudinal metabolic changes of muscle physiological adaptation as the basis of stress memory.
C1 [Nikolic, Aleksandra; Fahlbusch, Pia; Wahlers, Natalie; Riffelmann, Nele-Kathrien; Jacob, Sylvia; Hartwig, Sonja; Kettel, Ulrike; Dille, Matthias; Al-Hasani, Hadi; Kotzka, Joerg; Knebel, Birgit] Univ Duesseldorf, Inst Clin Biochem & Pathobiochemistry, German Diabet Ctr Heinrich Heine, Leibniz Ctr Diabet Res, D-40225 Dusseldorf, Germany.
   [Nikolic, Aleksandra; Fahlbusch, Pia; Riffelmann, Nele-Kathrien; Hartwig, Sonja; Al-Hasani, Hadi; Kotzka, Joerg; Knebel, Birgit] German Ctr Diabet Res DZD, Partner Duesseldorf, D-40225 Dusseldorf, Germany.
   [Al-Hasani, Hadi] Univ Dusseldorf, Med Fac Heinrich Heine, D-40225 Dusseldorf, Germany.
C3 Leibniz Association; Deutsches Diabetes-Zentrum (DDZ); German Center for
   Diabetes Research (DZD); Heinrich Heine University Dusseldorf
RP Knebel, B (corresponding author), Univ Duesseldorf, Inst Clin Biochem & Pathobiochemistry, German Diabet Ctr Heinrich Heine, Leibniz Ctr Diabet Res, D-40225 Dusseldorf, Germany.; Knebel, B (corresponding author), German Ctr Diabet Res DZD, Partner Duesseldorf, D-40225 Dusseldorf, Germany.
EM birgit.knebel@ddz.de
OI Kotzka, Jorg/0000-0003-1173-9372; Nikolic,
   Aleksandra/0000-0001-9076-3447; Al-Hasani, Hadi/0000-0003-2543-0130
FU Projekt DEAL; German Diabetes Center (DDZ) - German Federal Ministry of
   Health; Ministry of Innovation, Science, Research, and Technology of the
   state of North Rhine-Westphalia; German Federal Ministry of Education
   and Research (BMBF)
FX Open Access funding enabled and organized by Projekt DEAL. The work was
   supported by the German Diabetes Center (DDZ), which is funded by the
   German Federal Ministry of Health and the Ministry of Innovation,
   Science, Research, and Technology of the state of North
   Rhine-Westphalia. This study was supported in part by a grant from the
   German Federal Ministry of Education and Research (BMBF) to the German
   Center for Diabetes Research (DZD e.V), Muenchen-Neuherberg.
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NR 78
TC 2
Z9 2
U1 2
U2 3
PU SPRINGER BASEL AG
PI BASEL
PA PICASSOPLATZ 4, BASEL, 4052, SWITZERLAND
SN 1420-682X
EI 1420-9071
J9 CELL MOL LIFE SCI
JI Cell. Mol. Life Sci.
PD APR
PY 2023
VL 80
IS 4
AR 108
DI 10.1007/s00018-023-04761-4
PG 19
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA C2WC3
UT WOS:000960571000001
PM 36988756
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Zhou, X
   Han, DW
   Xu, RL
   Wu, HW
   Qu, CX
   Wang, F
   Wang, XY
   Zhao, YC
AF Zhou, Xin
   Han, Dewu
   Xu, Ruiling
   Wu, Huiwen
   Qu, Chongxiao
   Wang, Feng
   Wang, Xiangyu
   Zhao, Yuanchang
TI Glycine protects against high sucrose and high fat-induced nonalcoholic
   steatohepatitis in rats
SO ONCOTARGET
LA English
DT Article
DE glycine; non-alcoholic steatohepatitis; intestinal endotoxin;
   endoplasmic reticulum stress; oxidative stress; Pathology Section
ID ENDOPLASMIC-RETICULUM STRESS; INCREASED INTESTINAL PERMEABILITY; INDUCED
   OXIDATIVE STRESS; LIVER-DISEASE; BACTERIAL OVERGROWTH; ER STRESS;
   METABOLIC SYNDROME; KUPFFER CELLS; ENDOTOXIN; LIPOPOLYSACCHARIDE
AB We set out to explore the hypothesis that glycine attenuates non-alcoholic steatohepatitis (NASH) in rats and the possible mechanism by which is it does. Male Sprague-Dawley (SD) rats were fed a diet containing high fat and high sucrose (HSHF) for 24 weeks to induce NASH. Blood and liver tissues were sampled at selected time points throughout the study. Compared with control animals, the content of alanine transaminase (ALT), triglycerides (TGs), and free fatty acids (FFAs) in plasma and the TG and FFA content in the liver was increased from week 4 to 24. The level of TNFa and MCP-1 in plasma, the content of TNFa in the liver, the insulin resistance index, inflammatory cell infiltration, hepatocyte apoptosis, reactive oxygen species (ROS) generation, and endoplasmic stress-associated protein expression were unaltered at 4 weeks. However, these levels were significantly elevated in HSHF fed rats at 12 weeks. At the same time, the level of endotoxin progressively increased from 0.08 +/- 0.02 endotoxin EU/ml at week 4 to 0.7 +/- 0.19 EU/ml at week 24. Moreover, these rats had elevated blood endotoxin levels, which were positively associated with their NASH indexes. Liver histology progressively worsened over the course of the study. However, we found that with concomitant treatment with glycine, the level of endotoxin decreased, while NASH indexes significantly decreased and liver status markedly improved,. These data support the hypothesis that glycine protects against NASH in rats by decreasing the levels of intestinal endotoxin, alleviating endoplasmic reticulum and oxidative stress.
C1 [Zhou, Xin; Han, Dewu; Xu, Ruiling; Wu, Huiwen; Wang, Feng; Zhao, Yuanchang] Shanxi Med Univ, Dept Pathophysiol, Basic Med Sci, Taiyuan, Shanxi, Peoples R China.
   [Wu, Huiwen] Shanxi Med Univ, Fenyang Coll, Ctr Sci & Technol, Fenyang, Shanxi, Peoples R China.
   [Qu, Chongxiao] Shanxi Prov Peoples Hosp, Dept Pathol, Taiyuan, Shanxi, Peoples R China.
   [Wang, Xiangyu] Shanxi Med Univ, Dept Oral Med, Taiyuan, Shanxi, Peoples R China.
C3 Shanxi Medical University; Shanxi Medical University; Shanxi People's
   Hospital; Shanxi Medical University
RP Han, DW (corresponding author), Shanxi Med Univ, Dept Pathophysiol, Basic Med Sci, Taiyuan, Shanxi, Peoples R China.
EM xinxin6633@yeah.net
FU Doctoral Start up Research Fund of Shanxi Medical University
   [B03201203]; Youth Science and Technology Research Fund; Basic research
   projects in Shanxi [2014021040-3]; Scientific and Technological
   Innovation Programs of Higher Education [2013121]; Shanxi Province
   Natural and Science Foundation [2014011046-3]
FX The authors gratefully acknowledge the financial support by the Doctoral
   Start up Research Fund of Shanxi Medical University (No. B03201203), the
   Youth Science and Technology Research Fund, Basic research projects in
   Shanxi (No. 2014021040-3), Scientific and Technological Innovation
   Programs of Higher Education (No. 2013121), and Shanxi Province Natural
   and Science Foundation (No. 2014011046-3).
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NR 41
TC 29
Z9 40
U1 0
U2 8
PU IMPACT JOURNALS LLC
PI ORCHARD PARK
PA 6666 E QUAKER ST, STE 1, ORCHARD PARK, NY 14127 USA
EI 1949-2553
J9 ONCOTARGET
JI Oncotarget
PD DEC 6
PY 2016
VL 7
IS 49
BP 80223
EP 80237
DI 10.18632/oncotarget.12831
PG 15
WC Oncology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Cell Biology
GA EE8LO
UT WOS:000389877500014
PM 27784003
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Seal, SV
   Turner, JD
AF Seal, Snehaa, V
   Turner, Jonathan D.
TI The 'Jekyll and Hyde' of Gluconeogenesis: Early Life Adversity, Later
   Life Stress, and Metabolic Disturbances
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE glucose; glycogen; gluconeogenesis; early life adversity; acute stress;
   chronic stress; psychosocial stress; hypothalamus-pituitary-adrenal
   axis; ageing; immuno-senescence; inflamm-ageing; developmental origins
   of health and disease
ID PITUITARY-ADRENAL AXIS; TYPE-2 DIABETES-MELLITUS;
   GLUCOCORTICOID-RECEPTOR; CHILDHOOD EXPERIENCES; GLUCOSE-METABOLISM;
   CORTISOL SECRETION; INSULIN ACTION; ABUSE; MIDLIFE; FAT
AB The physiological response to a psychological stressor broadly impacts energy metabolism. Inversely, changes in energy availability affect the physiological response to the stressor in terms of hypothalamus, pituitary adrenal axis (HPA), and sympathetic nervous system activation. Glucocorticoids, the endpoint of the HPA axis, are critical checkpoints in endocrine control of energy homeostasis and have been linked to metabolic diseases including obesity, insulin resistance, and type 2 diabetes. Glucocorticoids, through the glucocorticoid receptor, activate transcription of genes associated with glucose and lipid regulatory pathways and thereby control both physiological and pathophysiological systemic energy homeostasis. Here, we summarize the current knowledge of glucocorticoid functions in energy metabolism and systemic metabolic dysfunction, particularly focusing on glucose and lipid metabolism. There are elements in the external environment that induce lifelong changes in the HPA axis stress response and glucocorticoid levels, and the most prominent are early life adversity, or exposure to traumatic stress. We hypothesise that when the HPA axis is so disturbed after early life adversity, it will fundamentally alter hepatic gluconeogenesis, inducing hyperglycaemia, and hence crystalise the significant lifelong risk of developing either the metabolic syndrome, or type 2 diabetes. This gives a "Jekyll and Hyde" role to gluconeogenesis, providing the necessary energy in situations of acute stress, but driving towards pathophysiological consequences when the HPA axis has been altered.
C1 [Seal, Snehaa, V; Turner, Jonathan D.] Luxembourg Inst Hlth LIH, Dept Infect & Immun, Immune Endocrine & Epigenet Res Grp, L-4354 Esch Sur Alzette, Luxembourg.
   [Seal, Snehaa, V] Univ Luxembourg, Fac Sci Technol & Med, L-4365 Esch Sur Alzette, Luxembourg.
C3 Luxembourg Institute of Health; University of Luxembourg
RP Turner, JD (corresponding author), Luxembourg Inst Hlth LIH, Dept Infect & Immun, Immune Endocrine & Epigenet Res Grp, L-4354 Esch Sur Alzette, Luxembourg.
EM snehaa.seal@lih.lu; jonathan.turner@lih.lu
RI Turner, Jonathan/C-4989-2016
OI Turner, Jonathan/0000-0002-2760-1071; Seal, Snehaa/0000-0002-9297-4616
FU Fonds National de Recherche Luxembourg [INTER/ANR/16/11568350]; FNR-CORE
   [C16/BM/11342695, C12/BM/3985792, C19/SC/13650569]
FX S.V.S. and J.D.T. were funded by Fonds National de Recherche Luxembourg
   (INTER/ANR/16/11568350 `MADAM'). The work of J.D.T. on the long term
   consequences of ELA was further funded by FNR-CORE C16/BM/11342695
   `MetCOEPs'; C12/BM/3985792 `EpiPath'; and C19/SC/13650569, "ALAC".
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NR 139
TC 28
Z9 30
U1 0
U2 18
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD APR
PY 2021
VL 22
IS 7
AR 3344
DI 10.3390/ijms22073344
PG 17
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Biochemistry & Molecular Biology; Chemistry
GA RK9XV
UT WOS:000638640400001
PM 33805856
OA Green Submitted, gold, Green Published
DA 2025-06-11
ER

PT J
AU Ren, LP
   Song, GY
   Hu, ZJ
   Zhang, MM
   Peng, LB
   Chen, SC
   Wei, LM
   Li, F
   Sun, W
AF Ren, Lu-Ping
   Song, Guang-Yao
   Hu, Zhi-Juan
   Zhang, Mingming
   Peng, Lanbo
   Chen, Shu-Chun
   Wei, Limin
   Li, Fan
   Sun, Wen
TI The chemical chaperon 4-phenylbutyric acid ameliorates hepatic steatosis
   through inhibition of de novo lipogenesis in high-fructose-fed
   rats
SO INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
LA English
DT Article
DE endoplasmic reticulum stress; fatty liver; fructose; lipogenesis
ID FATTY LIVER-DISEASE; ENDOPLASMIC-RETICULUM STRESS;
   NECROSIS-FACTOR-ALPHA; OXIDATIVE STRESS; METABOLIC SYNDROME; SIGNALING
   PATHWAY; ER STRESS; INSULIN; ACTIVATION; APOPTOSIS
AB Non-alcoholic fatty liver disease caused by dietary factors such as a high fructose intake is a growing global concern. The aim of this study was to investigate the intervention effects of an endoplasmic reticulum stress (ERS) inhibitor 4-phenylbutyric acid (PBA) on liver steatosis induced by high-fructose feeding in rats and the possible underlying mechanisms. Wistar rats were divided into the control, high-fructose group (HFru) and PBA intervention (HFru-PBA) groups. PBA intervention was initiated following 4 weeks of high-fructose feeding. After 8 weeks of feeding, the ERS markers p-PERK, p-eIF2 alpha, p-IRE-1, spliced XBP-1, ATF-6 were measured by western blotting. Liver triglyceride contents and morphological changes were examined. The protein expression of lipogenic key enzymes (ACC, FAS and SCD-1) and upstream transcriptional factors (SREBP-1c and ChREBP) were measured. The ERS-related cell events, oxidative stress and apoptosis, were evaluated by standard methods. Results demonstrated that PBA intervention significantly resolved hepatic ERS and improved liver steatosis induced by high-fructose feeding in rats. The protein expression of ACC, FAS, SCD-1 and SREBP-1c was upregulated in high-fructose-fed rats, whereas it decreased following PBA intervention. Oxidative stress and apoptosis were observed in livers of high-fructose-fed rats, but were alleviated by PBA intervention. ERS is involved in the development of fatty liver induced by a high fructose intake. ERS inhibition by PBA can therefore ameliorate liver steatosis through inhibition of hepatic lipogenesis.
C1 [Ren, Lu-Ping; Song, Guang-Yao; Peng, Lanbo; Chen, Shu-Chun; Wei, Limin; Li, Fan; Sun, Wen] Gen Hosp Hebei, Dept Endocrinol, Shijiazhuang 050051, Hebei, Peoples R China.
   [Hu, Zhi-Juan] Gen Hosp Hebei, Dept Nephrol, Shijiazhuang 050051, Hebei, Peoples R China.
   [Zhang, Mingming] Gen Hosp Hebei, Dept Clin Lab, Shijiazhuang 050051, Hebei, Peoples R China.
RP Song, GY (corresponding author), Gen Hosp Hebei, Dept Endocrinol, Heping Xi Rd 348, Shijiazhuang 050051, Hebei, Peoples R China.
EM sguangyao2@163.com
FU Chinese National Science Foundation [81200639]; International
   Cooperation Foundation Grant in Science and Technology Department of
   Hebei Province [11396406-D]
FX The authors thank Professor Jiming Ye (Health Innovations Research
   Institute, RMIT University, Melbourne, Victoria, Australia) for his
   advice on and interest in the study. This study has been supported by
   fundings from the Chinese National Science Foundation Grant (no.
   81200639; allocation to L.-P. R.; 2012) and from the International
   Cooperation Foundation Grant in Science and Technology Department of
   Hebei Province (no. 11396406-D; allocation to G.-Y.S.; 2011).
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NR 35
TC 20
Z9 25
U1 0
U2 16
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1107-3756
EI 1791-244X
J9 INT J MOL MED
JI Int. J. Mol. Med.
PD NOV
PY 2013
VL 32
IS 5
BP 1029
EP 1036
DI 10.3892/ijmm.2013.1493
PG 8
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 225SL
UT WOS:000324982500007
PM 24042997
OA Bronze
DA 2025-06-11
ER

PT J
AU Wang, J
   Wang, L
   Zhang, XJ
   Zhang, P
   Cai, JJ
   She, ZG
   Li, HL
AF Wang, Jia
   Wang, Lei
   Zhang, Xiao-Jing
   Zhang, Peng
   Cai, Jingjing
   She, Zhi-Gang
   Li, Hongliang
TI Recent updates on targeting the molecular mediators of NAFLD
SO JOURNAL OF MOLECULAR MEDICINE-JMM
LA English
DT Review
DE Nonalcoholic fatty liver disease; Nonalcoholic steatohepatitis;
   Lipotoxicity; Inflammation; Oxidative stress; Gut homeostasis
ID NONALCOHOLIC FATTY LIVER; PATTERN-RECOGNITION RECEPTORS; REDUCES HEPATIC
   STEATOSIS; BINDING PROTEIN CHREBP; PPAR-ALPHA; INSULIN-RESISTANCE;
   DOUBLE-BLIND; EXPRESSION PATTERNS; OXIDATIVE STRESS; GENE-EXPRESSION
AB Nonalcoholic fatty liver disease (NAFLD) is rapidly becoming the most common disease worldwide in an era of rapid economic growth. NAFLD is a multifactorial disease, involving multiple genetic, metabolic, and environmental factors, and is closely associated with metabolic syndrome, obesity, and cardiovascular disease. NAFLD can be classified into nonalcoholic fatty liver disease (NAFL) and nonalcoholic steatohepatitis (NASH), which can both progress to cirrhosis and even hepatocellular carcinoma (HCC). Due to the enormous burden of NAFLD and its complications, no FDA-approved drugs for the treatment of NAFLD are on the market, and therapeutic targets and drug therapies are being actively investigated. In view of the various pathological mechanisms of NAFLD, numbers of preclinical studies and clinical trials have made rapid progress. This review mainly summarizes the most recently characterized mechanisms and therapeutic targets in each mechanism of NAFLD, focusing on the mechanism and application potential.
C1 [Wang, Jia; She, Zhi-Gang; Li, Hongliang] Wuhan Univ, Renmin Hosp, Dept Cardiol, Wuhan, Peoples R China.
   [Wang, Jia; Zhang, Xiao-Jing; Zhang, Peng; Cai, Jingjing; She, Zhi-Gang; Li, Hongliang] Wuhan Univ, Inst Model Anim, Wuhan, Peoples R China.
   [Wang, Lei] Yangtze Univ, Huanggang Cent Hosp, Dept Neurosurg, Huanggang, Peoples R China.
   [Wang, Lei; Li, Hongliang] Yangtze Univ, Translat Med Res Ctr, Huanggang, Peoples R China.
   [Zhang, Xiao-Jing; Zhang, Peng] Wuhan Univ, Sch Basic Med Sci, Wuhan, Peoples R China.
   [Cai, Jingjing] Cent South Univ, Xiangya Hosp 3, Dept Cardiol, Changsha, Peoples R China.
C3 Wuhan University; Wuhan University; Yangtze University; Yangtze
   University; Wuhan University; Central South University
RP She, ZG; Li, HL (corresponding author), Wuhan Univ, Renmin Hosp, Dept Cardiol, Wuhan, Peoples R China.; She, ZG; Li, HL (corresponding author), Wuhan Univ, Inst Model Anim, Wuhan, Peoples R China.; Li, HL (corresponding author), Yangtze Univ, Translat Med Res Ctr, Huanggang, Peoples R China.
EM zgshe@whu.edu.cn; lihl@whu.edu.cn
RI Cai, Jingjing/JXN-8391-2024; She, Zhi-Gang/AFP-9194-2022
OI She, Zhi-Gang/0000-0001-9402-4166
FU National Sci-ence Foundation of China [81970364, 81770053, 82170595,
   81970070, 81870171, 82170436]; Hubei Province Innovation Platform
   Construction [20204201117303072238]
FX This work was supported by grants from the National Sci-ence Foundation
   of China (81970364, 81770053, 82170595, 81970070, 81870171, 82170436),
   and the Hubei Province Innovation Platform Construction Project
   (20204201117303072238).
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NR 197
TC 8
Z9 8
U1 2
U2 51
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0946-2716
EI 1432-1440
J9 J MOL MED
JI J. Mol. Med.
PD FEB
PY 2023
VL 101
IS 1-2
BP 101
EP 124
DI 10.1007/s00109-022-02282-4
EA FEB 2023
PG 24
WC Genetics & Heredity; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Genetics & Heredity; Research & Experimental Medicine
GA 9L0AB
UT WOS:000933495700001
PM 36792729
DA 2025-06-11
ER

PT J
AU Dong, J
   Shin, N
   Chen, SQ
   Lei, J
   Burd, I
   Wang, XH
AF Dong, Jie
   Shin, Na
   Chen, Shuqiang
   Lei, Jun
   Burd, Irina
   Wang, Xiaohong
TI Is there a definite relationship between placental mTOR signaling and
   fetal growth?
SO BIOLOGY OF REPRODUCTION
LA English
DT Review
DE placenta; mTOR signaling; fetal development; intrauterine growth
   restriction; macrosomia
ID GESTATIONAL DIABETES-MELLITUS; ENDOPLASMIC-RETICULUM STRESS; AMINO-ACID
   TRANSPORTERS; MAMMALIAN TARGET; MATERNAL OBESITY; MOUSE MODEL;
   MECHANISTIC TARGET; GLUCOSE-METABOLISM; DOWN-REGULATION; PREGNANT MICE
AB Fetal growth restriction and overgrowth are common obstetrical complications that result in adverse perinatal outcomes and long-term health risks later in life, including neurodevelopmental dysfunction and adult metabolic syndrome. The placenta plays a critical role in the nutrition transfer from mother to fetus and even exerts adaptive mechanism when the fetus is under poor developmental conditions. The mammalian/mechanistic target of rapamycin (mTOR) signaling serves as a critical hub of cell growth, survival, and metabolism in response to nutrients, growth factors, energy, and stress signals. Placental mTOR signaling regulates placental function, including oxygen and nutrient transport. Therefore, placental mTOR signaling is hypothesized to have a positive relationship with fetal growth. In this review, we summarize that most studies support the current evidence that there is connection between placental mTOR signaling and abnormal fetal growth; however, but more studies should be performed following a vigorous and unanimous method for assessment to determine placental mTOR activity.
C1 [Dong, Jie; Chen, Shuqiang; Wang, Xiaohong] Air Force Med Univ, Tangdu Hosp, Reprod Med Ctr, Dept Gynecol & Obstet, Xian 710038, Shaanxi, Peoples R China.
   [Shin, Na; Lei, Jun; Burd, Irina] Johns Hopkins Univ, Integrated Res Ctr Fetal Med, Dept Gynecol & Obstet, Sch Med, Phipps 228,600 N Wolfe St, Baltimore, MD 21287 USA.
C3 Air Force Medical University; Johns Hopkins University
RP Wang, XH (corresponding author), Air Force Med Univ, Tangdu Hosp, Reprod Med Ctr, Dept Gynecol & Obstet, Xian 710038, Shaanxi, Peoples R China.; Burd, I (corresponding author), Johns Hopkins Univ, Integrated Res Ctr Fetal Med, Dept Gynecol & Obstet, Sch Med, Phipps 228,600 N Wolfe St, Baltimore, MD 21287 USA.
EM iburd@jhmi.edu; wangxh-99919@163.com
RI Dong, Jie/AAW-2662-2021
OI Dong, Jie/0000-0001-6786-1057; Lei, Jun/0000-0002-2120-3830
FU National Natural Science Foundation of China [81671463]; Key Research
   and Development Plan of Shaanxi Province [2017ZDCXL-SF-02-03]
FX This work was funded by grants from the National Natural Science
   Foundation of China (81671463) and the Key Research and Development Plan
   of Shaanxi Province (2017ZDCXL-SF-02-03).
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NR 106
TC 22
Z9 23
U1 0
U2 14
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0006-3363
EI 1529-7268
J9 BIOL REPROD
JI Biol. Reprod.
PD SEP
PY 2020
VL 103
IS 3
BP 471
EP 486
DI 10.1093/biolre/ioaa070
PG 16
WC Reproductive Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Reproductive Biology
GA OW6CW
UT WOS:000592973100005
PM 32401303
DA 2025-06-11
ER

PT J
AU Di Monaco, A
   Bruno, I
   Calcagni, ML
   Nerla, R
   Lamendola, P
   Barone, L
   Scalone, G
   Mollo, R
   Coviello, I
   Bagnato, A
   Sestito, A
   Giordano, A
   Lanza, GA
   Crea, F
AF Di Monaco, Antonio
   Bruno, Isabella
   Calcagni, Maria Lucia
   Nerla, Roberto
   Lamendola, Priscilla
   Barone, Lucy
   Scalone, Glancarla
   Mollo, Roberto
   Coviello, Ilaria
   Bagnato, Antonio
   Sestito, Alfonso
   Giordano, Alessandro
   Lanza, Gaetano A.
   Crea, Filippo
TI Cardiac adrenergic nerve function in patients with cardiac syndrome X
SO JOURNAL OF CARDIOVASCULAR MEDICINE
LA English
DT Article
DE I-123-metaiodobenzylguanidine uptake; adrenergic nerve function; cardiac
   syndrome X
ID MYOCARDIAL-INFARCTION; ANGINA-PECTORIS; HEART; METAIODOBENZYLGUANIDINE;
   DENERVATION; MECHANISMS
AB Background We previously found a severe impairment of cardiac uptake of I-123-metaiodobenzylguanidine (MIBG), an analogue of norepinephrine, on myocardial scintigraphy in a small group of patients with cardiac syndrome X (CSX), suggesting a dysfunction of cardiac adrenergic nerve fibres. In this study, we assessed the consistency of these previous findings in a larger group of these patients.
   Methods Planar and single-photon emission computed tomography MIBG myocardial scintigraphy was performed in 40 CSX patients (58 +/- 7 years, 17 men). Cardiac MIBG uptake was measured by the heart/mediastinum ratio and by a single-photon emission computed tomography regional cardiac MIBG uptake defect score (higher values = lower uptake). As a control group, we studied 20 healthy individuals (56 +/- 6 years, nine men). An exercise stress Tc-99m-SestaMIBI myocardial scintigraphy was performed in 34 CSX patients (85%).
   Results Cardiac MIBG defects were observed in 30 patients (75%), with nine (22.5%) showing no cardiac MIBG uptake at all. Compared with controls, CSX patients showed a significantly lower heart/mediastinum ratio (1.70 +/- 0.35 vs. 2.1 +/- 0.22, P<0.001) and a higher cardiac MIBG defect score (27 +/- 25 vs. 4.4 +/- 2.5, P<0.001). No differences were found in lung MIBG uptake between the two groups. Reversible perfusion defects on stress myocardial scintigraphy were found in 17 out of 34 CSX patients (50%), all of whom also had abnormal cardiac MIBG uptake; cardiac MIBG uptake abnormalities were also present in nine of 17 patients with normal perfusion scintigraphic images. Cardiac MIBG uptake findings were similar in our first 12 patients and in the 28 patients studied subsequently.
   Conclusion Our data show a relevant impairment of cardiac MIBG uptake in patients with CSX, suggesting that functional abnormalities in cardiac adrenergic nerve function may play a significant role in the mechanisms responsible for the syndrome. J Cardiovasc Med 11:151-156 (C) 2010 Italian Federation of Cardiology.
C1 [Di Monaco, Antonio; Nerla, Roberto; Lamendola, Priscilla; Barone, Lucy; Scalone, Glancarla; Mollo, Roberto; Coviello, Ilaria; Sestito, Alfonso; Lanza, Gaetano A.; Crea, Filippo] Univ Cattolica Sacro Cuore, Ist Cardiol, I-00168 Rome, Italy.
   [Bruno, Isabella; Calcagni, Maria Lucia; Giordano, Alessandro] Univ Cattolica Sacro Cuore, Ist Med Nucl, I-00168 Rome, Italy.
   [Bagnato, Antonio] Azienda Osped, Unita Operat Med Nucl, Cosenza, Italy.
C3 Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli;
   Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli;
   Azienda Ospedaliera di Cosenza
RP Lanza, GA (corresponding author), Univ Cattolica Sacro Cuore, Ist Cardiol, Largo A Gemelli 8, I-00168 Rome, Italy.
EM g.a.lanza@inwind.it
RI Calcagni, Maria Lucia/AAC-7214-2022; Crea, Filippo/AAC-9754-2022; Nerla,
   Roberto/AAL-1534-2020; Giordano, Alessandro/AAW-9921-2021; BArone,
   Lucy/JFS-7992-2023; Lanza, Gaetano/AAC-2660-2019; Di monaco,
   Antonio/AAR-8825-2021
OI Barone, Lucy/0000-0001-9476-9168; Nerla, Roberto/0000-0002-9065-3261;
   Giordano, Alessandro/0000-0002-6978-0880; Di monaco,
   Antonio/0000-0002-1297-2056
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NR 15
TC 13
Z9 13
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1558-2027
EI 1558-2035
J9 J CARDIOVASC MED
JI J. Cardiovasc. Med.
PD MAR
PY 2010
VL 11
IS 3
BP 151
EP 156
DI 10.2459/JCM.0b013e328330321d
PG 6
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 555IX
UT WOS:000274504400002
PM 20010111
DA 2025-06-11
ER

PT J
AU Ghosh, P
   Fontanella, RA
   Scisciola, L
   Taktaz, F
   Pesapane, A
   Basilicata, MG
   Tortorella, G
   Mattacchione, G
   Capuano, A
   Vietri, MT
   Selvaggi, F
   Paolisso, G
   Barbieri, M
AF Ghosh, Puja
   Fontanella, Rosaria Anna
   Scisciola, Lucia
   Taktaz, Fatemeh
   Pesapane, Ada
   Basilicata, Manuela Giovanna
   Tortorella, Giovanni
   Mattacchione, Giulia
   Capuano, Annalisa
   Vietri, Maria Teresa
   Selvaggi, Francesco
   Paolisso, Giuseppe
   Barbieri, Michelangela
TI Obesity-induced neuronal senescence: Unraveling the pathophysiological
   links
SO AGEING RESEARCH REVIEWS
LA English
DT Review
DE Obesity; Neuronal senescence; Cognitive decline; SASP; Adipokines
ID COGNITIVE IMPAIRMENT; CELLULAR SENESCENCE; OXIDATIVE STRESS;
   MITOCHONDRIAL DYSFUNCTION; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   LEPTIN RECEPTOR; ADIPOSE-TISSUE; BRAIN BARRIERS; WEIGHT-LOSS
AB Obesity is one of the most prevalent and increasing metabolic disorders and is considered one of the twelve risk factors for dementia. Numerous studies have demonstrated that obesity induces pathophysiological changes leading to cognitive decline; however, the underlying molecular mechanisms are yet to be fully elucidated. Various biochemical processes, including chronic inflammation, oxidative stress, insulin resistance, dysregulation of lipid metabolism, disruption of the blood-brain barrier, and the release of adipokines have been reported to contribute to the accumulation of senescent neurons during obesity. These senescent cells dysregulate neuronal health and function by exhibiting a senescence-associated secretory phenotype, inducing neuronal inflammation, deregulating cellular homeostasis, causing mitochondrial dysfunction, and promoting microglial infiltration. These factors act as major risks for the occurrence of neurodegenerative diseases and cognitive decline. This review aims to focus on how obesity upregulates neuronal senescence and explores both pharmacological and non-pharmacological interventions for preventing cognitive impairments, thus offering new insights into potential therapeutic strategies.
C1 [Ghosh, Puja; Fontanella, Rosaria Anna; Scisciola, Lucia; Taktaz, Fatemeh; Pesapane, Ada; Basilicata, Manuela Giovanna; Tortorella, Giovanni; Selvaggi, Francesco; Paolisso, Giuseppe; Barbieri, Michelangela] Univ Campania Luigi Vanvitelli, Dept Adv Med & Surg Sci, Naples, Italy.
   [Mattacchione, Giulia] IRCCS INRCA, Clin Lab & Precis Med, Ancona, Italy.
   [Capuano, Annalisa] Univ Campania Luigi Vanvitelli, Dept Expt Med, Sect Pharmacol L Donatelli, I-80138 Naples, Italy.
   [Vietri, Maria Teresa] Univ Campania Luigi Vanvitelli, Dept Precis Med, Via L De Crecchio, I-80138 Naples, Italy.
   [Vietri, Maria Teresa] AOU Univ Campania Luigi Vanvitelli, UOC Clin & Mol Pathol, I-80138 Naple, Italy.
   [Paolisso, Giuseppe] Int Med Univ, UniCamillus, Rome, Italy.
C3 Universita della Campania Vanvitelli; IRCCS INRCA; Universita della
   Campania Vanvitelli; Universita della Campania Vanvitelli
RP Barbieri, M (corresponding author), Univ Campania Luigi Vanvitelli, Dept Adv Med & Surg Sci, Naples, Italy.
EM michelangela.barbieri@unicampania.it
RI Taktaz, Fatemeh/JQV-8549-2023; Capuano, Annalisa/HTL-3144-2023;
   Tortorella, giovanni/KCX-6966-2024; Pesapane, Ada/CAG-3674-2022
OI , fatemeh/0000-0002-6521-4478
FU Ministero dell' Istruzione, dell ' Universita e della Ricerca
   Scientifica [2020N5WK98]
FX This work was supported by Ministero dell ' Istruzione, dell '
   Universita e della Ricerca Scientifica (Grants PRIN 2020), No. Prot.
   2020N5WK98.
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NR 168
TC 3
Z9 3
U1 3
U2 5
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 1568-1637
EI 1872-9649
J9 AGEING RES REV
JI Ageing Res. Rev.
PD NOV
PY 2024
VL 101
AR 102533
DI 10.1016/j.arr.2024.102533
EA OCT 2024
PG 11
WC Cell Biology; Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Geriatrics & Gerontology
GA I8K3Z
UT WOS:001332687100001
PM 39368666
DA 2025-06-11
ER

PT J
AU Kim, H
   Kang, SM
   Go, GW
AF Kim, Hayoon
   Kang, Sumin
   Go, Gwang-woong
TI Exploring the multifaceted role of ginkgolides and bilobalide from
   Ginkgo biloba in mitigating metabolic disorders
SO FOOD SCIENCE AND BIOTECHNOLOGY
LA English
DT Review
DE Bilobalide; Ginkgolide; Cognitive impairment; Blood circulation;
   Metabolic syndrome
ID PLATELET-ACTIVATING-FACTOR; NF-KAPPA-B; OXIDATIVE STRESS;
   CARDIOVASCULAR-DISEASE; INFLAMMATORY RESPONSE; LIPID-ACCUMULATION;
   ALZHEIMERS-DISEASE; INSULIN-RESISTANCE; ENDOTHELIAL-CELLS; 3T3-L1
   ADIPOCYTES
AB The ancient Ginkgo biloba tree grows across various regions, with distinctive leaves emitting a unique fragrance. Its extract contains flavonoids, organic acids, and terpenoids. Ginkgolide and bilobalide, which are G. biloba leaf extracts, offer diverse pharmaceutical benefits, including antioxidant, anti-inflammatory, and neuroprotective properties. The antioxidant and anti-inflammatory properties of these compounds are crucial for mitigating neurodegeneration, particularly in diseases such as Alzheimer's disease. Additionally, their effectiveness in countering oxidative stress and inflammation highlights their potential to prevent cardiovascular ailments. This study also suggests that these compounds have a promising impact on lipid metabolism, suggesting their significance in addressing obesity-related metabolic disorders. In conclusion, ginkgolides and bilobalide exhibit promising effects in sustaining the integrity of the nervous and endocrine systems, along with the modulation of lipid metabolism. The diverse health benefits suggest that these compounds could serve as promising therapeutic interventions for various conditions, including neurological, cardiovascular, and metabolic diseases.
C1 [Kim, Hayoon; Kang, Sumin; Go, Gwang-woong] Hanyang Univ, Dept Food & Nutr, Seoul 04763, South Korea.
C3 Hanyang University
RP Go, GW (corresponding author), Hanyang Univ, Dept Food & Nutr, Seoul 04763, South Korea.
EM kimhayoon0408@gmail.com; sumin.kang708@gmail.com; gwgo1015@hanyang.ac.kr
RI Go, Gwang-woong/AGM-4417-2022
OI Go, Gwang-woong/0000-0002-3848-8705
FU National Research Foundation of Korea [NRF-2022R1A2C1006193]
FX This study was funded by National Research Foundation of Korea,
   NRF-2022R1A2C1006193, Gwang-woong Go.
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NR 130
TC 3
Z9 3
U1 10
U2 15
PU KOREAN SOCIETY FOOD SCIENCE & TECHNOLOGY-KOSFOST
PI SEOUL
PA #605, KOREA SCI TECHNOL CENT, 635-4 YEOKSAM-DONG, KANGNAM-GU, SEOUL,
   135-703, SOUTH KOREA
SN 1226-7708
EI 2092-6456
J9 FOOD SCI BIOTECHNOL
JI Food Sci. Biotechnol.
PD OCT
PY 2024
VL 33
IS 13
BP 2903
EP 2917
DI 10.1007/s10068-024-01656-3
EA JUL 2024
PG 15
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA E4G3F
UT WOS:001269779000001
PM 39234277
DA 2025-06-11
ER

PT J
AU Nishimura, N
   Tanabe, H
   Yamamoto, T
AF Nishimura, Naomichi
   Tanabe, Hiroki
   Yamamoto, Tatsuro
TI Sufficient intake of high amylose cornstarch maintains high colonic
   hydrogen production for 24h in rats
SO BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
LA English
DT Article
DE hydrogen; high amylose cornstarch; resistant starch; colonic
   fermentation; rats
ID RESISTANT STARCH; OXIDATIVE STRESS; METABOLIC SYNDROME; BREATH-HYDROGEN;
   GAS-PRODUCTION; TRANSIT-TIME; RICH WATER; IN-VITRO; EXCRETION; INJURY
AB Colonic hydrogen (H-2) can suppress oxidative stress and damage in the body. We examined the minimum requirement of high amylose cornstarch (HAS) to maintain high colonic H-2 production for 24h. Ileorectostomized and sham-operated rats were fed a control diet supplemented with or without 20% HAS for 7days. Colonic starch utilization was determined. Next, rats were fed the control diet with or without 10% or 20% HAS for 14 or 28days, respectively. Breath and flatus H-2 excretion for 24h was measured. 1.04g of resistant fraction in HAS was utilized for 24h by colonic bacteria. High H-2 excretion was not maintained for 24h in rats fed the 10% HAS diet, from which only 0.89g of resistant starch was estimated to be delivered. High colonic H-2 production for 24h would be maintained by delivering more HAS to the large intestine than is utilized.
C1 [Nishimura, Naomichi] Shizuoka Univ, Acad Inst, Coll Agr, Shizuoka, Japan.
   [Nishimura, Naomichi; Tanabe, Hiroki; Yamamoto, Tatsuro] Nayoro City Univ, Fac Hlth & Welf Sci, Dept Nutr Sci, Nayoro, Japan.
C3 Shizuoka University
RP Nishimura, N (corresponding author), Shizuoka Univ, Acad Inst, Coll Agr, Shizuoka, Japan.; Nishimura, N (corresponding author), Nayoro City Univ, Fac Hlth & Welf Sci, Dept Nutr Sci, Nayoro, Japan.
EM nishimura.naomichi@shizuoka.ac.jp
RI Nishimura, Naomichi/AAJ-3144-2020
OI Nishimura, Naomichi/0000-0002-6459-726X
FU Japan Society for the Promotion of Science, Japan [26560059];
   Grants-in-Aid for Scientific Research [16H03036, 26560059] Funding
   Source: KAKEN
FX This work was supported by a Grant-in-Aid for Scientific Research [grant
   number 26560059] from the Japan Society for the Promotion of Science,
   Japan.
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NR 32
TC 3
Z9 3
U1 0
U2 8
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0916-8451
EI 1347-6947
J9 BIOSCI BIOTECH BIOCH
JI Biosci. Biotechnol. Biochem.
PD JAN
PY 2017
VL 81
IS 1
BP 173
EP 180
DI 10.1080/09168451.2016.1234929
PG 8
WC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
   Chemistry, Applied; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
   Chemistry; Food Science & Technology
GA EE1DI
UT WOS:000389320700026
PM 27885933
OA Bronze
DA 2025-06-11
ER

PT J
AU Vitek, L
   Bellarosa, C
   Tiribelli, C
AF Vitek, Libor
   Bellarosa, Cristina
   Tiribelli, Claudio
TI Induction of Mild Hyperbilirubinemia: Hype or Real Therapeutic
   Opportunity?
SO CLINICAL PHARMACOLOGY & THERAPEUTICS
LA English
DT Review
ID SERUM BILIRUBIN LEVELS; ISCHEMIC-HEART-DISEASE;
   UDP-GLUCURONOSYLTRANSFERASE; GILBERT-SYNDROME; MENDELIAN RANDOMIZATION;
   ELEVATED BILIRUBIN; HEME OXYGENASE-1; RISK; UGT1A1; ASSOCIATION
AB Observational epidemiological studies showed that mild hyperbilirubinemia has beneficial effects on the prevention of cardiovascular disease, type 2 diabetes mellitus, and metabolic syndrome. In mammals, bilirubin plays a major role as a potent antioxidant. Uridine 5'-diphospho-glucuronosyl transferase (UGT)1A1 variants coding for bilirubin UDP-glucuronosyl transferase resulting in mild hyperbilirubinemia (as in Gilbert syndrome (GS)) may confer a strong genetic advantage. Strategies to boost bioavailability of bilirubin or to mimic GS represent an attractive approach to prevent many oxidative stress and inflammation-mediated diseases. Even a tiny, micromolar increase in serum bilirubin concentrations substantially decreases the risk of oxidative stress-mediated diseases. There are several possible ways to achieve this, including lifestyle changes, changes in dietary patterns, regular physical activities, or use of chemical drug or of specific plant products either in the form of regular food items or nutraceuticals. Further basic and experimental research is required to fully uncover this promising therapeutic field.
C1 [Vitek, Libor] Charles Univ Prague, Inst Med Biochem, Prague, Czech Republic.
   [Vitek, Libor] Charles Univ Prague, Lab Diagnost, Prague, Czech Republic.
   [Vitek, Libor] Charles Univ Prague, Dept Internal Med 4, Fac Med 1, Prague, Czech Republic.
   [Bellarosa, Cristina; Tiribelli, Claudio] Fdn Italiana Fegato ONLUS, AREA Sci Pk Basovizza, Trieste, Italy.
C3 Charles University Prague; Charles University Prague; Charles University
   Prague
RP Bellarosa, C (corresponding author), Fdn Italiana Fegato ONLUS, AREA Sci Pk Basovizza, Trieste, Italy.
EM cristina.bellarosa@fegato.it
RI Tiribelli, Claudio/A-4716-2014; Vitek, Libor/A-2645-2008
OI Tiribelli, Claudio/0000-0001-6596-7595; Bellarosa,
   Cristina/0000-0002-2865-2575; Vitek, Libor/0000-0002-5318-0151
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NR 78
TC 54
Z9 54
U1 0
U2 11
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0009-9236
EI 1532-6535
J9 CLIN PHARMACOL THER
JI Clin. Pharmacol. Ther.
PD SEP
PY 2019
VL 106
IS 3
BP 568
EP 575
DI 10.1002/cpt.1341
PG 8
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA IQ2MJ
UT WOS:000480582800024
PM 30588615
DA 2025-06-11
ER

PT J
AU Kaur, S
   Rubal
   Kaur, S
   Kaur, A
   Kaur, S
   Gupta, S
   Mittal, S
   Dhiman, M
AF Kaur, Sukhchain
   Rubal
   Kaur, Satveer
   Kaur, Amandeep
   Kaur, Sandeep
   Gupta, Sushil
   Mittal, Sunil
   Dhiman, Monisha
TI A cross-sectional study to correlate antioxidant enzymes, oxidative
   stress and inflammation with prevalence of hypertension
SO LIFE SCIENCES
LA English
DT Article
DE Hypertension; Coronary heart diseases; Oxidative stress; Antioxidant
   enzymes
ID METABOLIC SYNDROME; LIPID-PEROXIDATION; NITRIC-OXIDE;
   GENDER-DIFFERENCES; PROTEIN PRODUCTS; FOLLOW-UP; DAMAGE;
   MYELOPEROXIDASE; PROGRESSION; THERAPY
AB Aims: Hypertension a multifactorial consequence of environmental factors, life style and genetics is the well -recognized risk factor contributing to coronary heart diseases. The antioxidant imbalance, excessive reactive oxygen species (ROS) leads to oxidative stress which is pivotal in progression of hypertension. The present study aims to understand the complex interaction between oxidative stress, inflammation and antioxidant system which is crucial to maintain cellular homeostasis which further can exaggerate hypertension pathophysiology.Materials and methods: The metabolic profile of hypertensive and normotensive subjects from Malwa region, Punjab was compared by estimating lipid profile, cardiac, hepatic and renal markers. The oxidative stress markers (protein carbonyls and lipid peroxidation), inflammatory markers (Nitric oxide, Myeloperoxidase and advanced oxygen protein products), and antioxidant enzymes (Superoxide Dismutase, Catalase, and Total Antioxidant Capacity) were analyzed. Key findings: It is observed that the metabolic markers are altered in hypertensive subjects which further these subjects showed increased oxidative, inflammatory profile and compromised antioxidant status when compared with normotensive subjects. Co-relation analysis validated the involvement of inflammation and oxidative stress in impaired endothelial function and vital organ damage.of study: These markers may act as early indicators of hypertension which usually do not show any physical symptoms, thus can be diagnosed and treated at the earliest. The current study suggests that disturbed homeostasis, a consequence of altered interaction between antioxidant system and inflammatory events raises the oxidative stress levels which eventually leads to hypertension and associated complications. These indicators can serve as early indicators of future chronic complications of hypertension.
C1 [Kaur, Sukhchain; Rubal; Kaur, Satveer; Kaur, Amandeep; Kaur, Sandeep; Gupta, Sushil; Dhiman, Monisha] Cent Univ Punjab Bathinda, Sch Basic Sci, Dept Microbiol, Bathinda, India.
   [Mittal, Sunil] Cent Univ Punjab Bathinda, Sch Environm & Earth Sci, Dept Environm Sci & Technol, Bathinda, India.
C3 Central University of Punjab; Central University of Punjab
RP Dhiman, M (corresponding author), Cent Univ Punjab Bathinda, Sch Basic Sci, Dept Microbiol, Bathinda, India.
EM monisha.dhiman@cup.edu.in
RI KUMAR, YOGESH/AAA-1235-2022; Kaur, Amandeep/IYJ-2622-2023; Hafezi,
   Mohammad/A-1197-2008; KAUR, SUKHCHAIN/GWM-7326-2022
OI KAUR, SUKHCHAIN/0000-0002-9698-3835
FU Rajiv Gandhi National Fellowship, Govt. of India; Central University of
   Punjab [GP-62]; Central Instrumentation Laboratory (CIL)
FX The current research work is supported from Rajiv Gandhi National
   Fellowship, Govt. of India to S.K, and Rubal. Community Development Cell
   and Institutional grant (GP-62) from Central University of Punjab and
   Central Instrumentation Laboratory (CIL) are thankfully acknowledged.
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NR 119
TC 9
Z9 9
U1 3
U2 8
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0024-3205
EI 1879-0631
J9 LIFE SCI
JI Life Sci.
PD JAN 15
PY 2023
VL 313
AR 121134
DI 10.1016/j.lfs.2022.121134
EA DEC 2022
PG 10
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA 7N2EN
UT WOS:000907157800001
PM 36544300
DA 2025-06-11
ER

PT J
AU Nowacka-Chmielewska, M
   Liskiewicz, D
   Liskiewicz, A
   Marczak, L
   Wojakowska, A
   Barski, JJ
   Malecki, A
AF Nowacka-Chmielewska, Marta
   Liskiewicz, Daniela
   Liskiewicz, Arkadiusz
   Marczak, Lukasz
   Wojakowska, Anna
   Jerzy Barski, Jaroslaw
   Malecki, Andrzej
TI Cerebrocortical proteome profile of female rats subjected to the western
   diet and chronic social stress
SO NUTRITIONAL NEUROSCIENCE
LA English
DT Article
DE Global brain proteome; western diet; chronic stress; female rats;
   metabolic parameters; obesity; temporal cortex; unhealthy lifestyle
ID HIGH-FAT; INDUCED OBESITY; CAFETERIA DIET; SYNAPTIC PLASTICITY;
   NEUROTROPHIC FACTOR; METABOLIC SYNDROME; 14-3-3 PROTEINS;
   SEX-DIFFERENCES; ADIPOSE-TISSUE; BRAIN
AB The energy-dense western diet significantly increases the risk of obesity, type 2 diabetes, cardiovascular episodes, stroke, and cancer. Recently more attention has been paid to the contribution of an unhealthy lifestyle on the development of central nervous system disorders. Exposure to long-lasting stress is one of the key lifestyle modifications associated with the increased prevalence of obesity and metabolic diseases. The main goal of the present study was to verify the hypothesis that exposure to chronic stress modifies alterations in the brain proteome induced by the western diet. Female adult rats were fed with the prepared chow reproducing the human western diet and/or subjected to chronic stress induced by social instability for 6 weeks. A control group of lean rats were fed with a standard diet. Being fed with the western diet resulted in an obese phenotype and induced changes in the serum metabolic parameters. The combination of the western diet and chronic stress exposure induced more profound changes in the rat cerebrocortical proteome profile than each of these factors individually. The down-regulation of proteins involved in neurotransmitter secretion (Rph3a, Snap25, Syn1) as well as in learning and memory processes (Map1a, Snap25, Tnr) were identified, while increased expression was detected for 14-3-3 protein gamma (Ywhag) engaged in the modulation of the insulin-signaling cascade in the brain. An analysis of the rat brain proteome reveals important changes that indicate that a combination of the western diet and stress exposure may lead to impairments of neuronal function and signaling.
C1 [Nowacka-Chmielewska, Marta; Liskiewicz, Daniela; Liskiewicz, Arkadiusz; Malecki, Andrzej] Jerzy Kukuczka Acad Phys Educ, Inst Physiotherapy & Hlth Sci, Lab Mol Biol, Katowice, Poland.
   [Liskiewicz, Arkadiusz; Jerzy Barski, Jaroslaw] Med Univ Silesia, Fac Med Sci Katowice, Dept Expt Med, Katowice, Poland.
   [Marczak, Lukasz; Wojakowska, Anna] Polish Acad Sci, Inst Bioorgan Chem, European Ctr Bioinformat & Genom, Poznan, Poland.
   [Jerzy Barski, Jaroslaw] Med Univ Silesia, Fac Med Sci Katowice, Dept Physiol, Katowice, Poland.
C3 Akademia Wychowania Fizycznego im. Jerzego Kukuczki w Katowicach;
   Medical University of Silesia; Polish Academy of Sciences; Institute of
   Bioorganic Chemistry of the Polish Academy of Sciences; Medical
   University of Silesia
RP Nowacka-Chmielewska, M (corresponding author), Jerzy Kukuczka Acad Phys Educ, Mol Biol Lab, Mikolowska 72 A, PL-40065 Katowice, Poland.
EM m.nowacka@awf.katowice.pl
RI Liśkiewicz, Daniela/AAW-3500-2020; Nowacka-Chmielewska,
   Marta/AAQ-1179-2020; Liskiewicz, Daniela/H-6962-2016; Liskiewicz,
   Arkadiusz/F-5336-2018; Marczak, Lukasz/C-9069-2011; Wojakowska,
   Anna/C-2075-2013; Barski, Jaroslaw/C-4792-2008
OI Liskiewicz, Daniela/0000-0002-5859-6316; Liskiewicz,
   Arkadiusz/0000-0002-4102-5373; Marczak, Lukasz/0000-0001-8602-0077;
   Wojakowska, Anna/0000-0002-4541-1239; Nowacka-Chmielewska,
   Marta/0000-0001-8668-8878; Barski, Jaroslaw/0000-0003-4590-1534
FU Polish National Science Centre [2015/19/D/NZ7/02408]; Jerzy Kukuczka
   Academy of Physical Education, Katowice, Poland [AWF/NF/2019/1]; Medical
   University of Silesia [KNW-1-153/K/9/O]; Narodowe Centrum Nauki
FX This work was supported by the Polish National Science Centre under
   Grant 2015/19/D/NZ7/02408 and the statutory grants: AWF/NF/2019/1 from
   the Jerzy Kukuczka Academy of Physical Education, Katowice, Poland and
   KNW-1-153/K/9/O from the Medical University of Silesia; Narodowe Centrum
   Nauki.
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NR 58
TC 6
Z9 6
U1 0
U2 13
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1028-415X
EI 1476-8305
J9 NUTR NEUROSCI
JI Nutr. Neurosci.
PD MAR 4
PY 2022
VL 25
IS 3
BP 567
EP 580
DI 10.1080/1028415X.2020.1770433
EA JUN 2020
PG 14
WC Neurosciences; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Nutrition & Dietetics
GA ZG0DA
UT WOS:000545502900001
PM 34000981
DA 2025-06-11
ER

PT J
AU Stephan, BCM
   Harrison, SL
   Keage, HAD
   Babateen, A
   Robinson, L
   Siervo, M
AF Stephan, Blossom C. M.
   Harrison, Stephanie L.
   Keage, Hannah A. D.
   Babateen, Abrar
   Robinson, Louise
   Siervo, Mario
TI Cardiovascular Disease, the Nitric Oxide Pathway and Risk of Cognitive
   Impairment and Dementia
SO CURRENT CARDIOLOGY REPORTS
LA English
DT Review
DE Cardiovascular disease; Cognitive impairment; Dementia; Endothelial
   function; Nitric oxide
ID DIETARY NITRATE SUPPLEMENTATION; ALZHEIMERS-DISEASE; ASYMMETRIC
   DIMETHYLARGININE; CEREBROSPINAL-FLUID; SYNTHASE INHIBITOR; METABOLIC
   SYNDROME; ENDOTHELIAL FUNCTION; ARTERIAL STIFFNESS; INCIDENT DEMENTIA;
   OXIDATIVE STRESS
AB Purpose of Review In this review, we summarise the evidence on the association between cardiovascular disease (CVD) and cognitive impairment and explore the role of the nitric oxide (NO) pathway as a causal mechanism.
   Recent Findings Evidence from epidemiological studies suggests that the presence of CVD and its risk factors in midlife is associated with an increased risk of later life cognitive impairment and dementia. It is unclear what is driving this association but risk may be conveyed via an increase in neurodegeneration (e.g. amyloid deposition), vascular changes (e.g. small vessel disease) and mechanistically due to increased levels of oxidative stress and inflammation as well as changes in NO bioavailability.
   Summary CVDs and dementia are major challenges to global health worldwide. The NO pathway may be a promising biological candidate for future studies focused on reducing not only CVD but also risk of cognitive decline and dementia.
C1 [Stephan, Blossom C. M.; Robinson, Louise] Newcastle Univ, Inst Hlth & Soc, Newcastle Biomed Res Bldg,Campus Ageing & Vital, Newcastle Upon Tyne NE4 5PL, Tyne & Wear, England.
   [Stephan, Blossom C. M.; Robinson, Louise] Newcastle Univ, Inst Ageing, Newcastle Biomed Res Bldg,Campus Ageing & Vital, Newcastle Upon Tyne NE4 5PL, Tyne & Wear, England.
   [Harrison, Stephanie L.] Flinders Univ S Australia, Sch Hlth Sci, Fac Med Nursing & Hlth Sci, Dept Rehabil Aged & Extended Care, Adelaide, SA, Australia.
   [Keage, Hannah A. D.] Univ South Australia, Sch Psychol Social Work & Social Policy, Cognit Ageing & Impairment Neurosci Lab, Adelaide, SA, Australia.
   [Babateen, Abrar; Siervo, Mario] Newcastle Univ, Inst Cellular Med, Newcastle Biomed Res Bldg,Campus Ageing & Vital, Newcastle Upon Tyne NE4 5PL, Tyne & Wear, England.
   [Babateen, Abrar] Umm Al Qura Univ, Fac Appl Med Sci, Dept Clin Nutr, Mecca, Saudi Arabia.
C3 Newcastle University - UK; Newcastle University - UK; Flinders
   University South Australia; University of South Australia; Newcastle
   University - UK; Umm Al-Qura University
RP Stephan, BCM (corresponding author), Newcastle Univ, Inst Hlth & Soc, Newcastle Biomed Res Bldg,Campus Ageing & Vital, Newcastle Upon Tyne NE4 5PL, Tyne & Wear, England.; Stephan, BCM (corresponding author), Newcastle Univ, Inst Ageing, Newcastle Biomed Res Bldg,Campus Ageing & Vital, Newcastle Upon Tyne NE4 5PL, Tyne & Wear, England.
EM blossom.stephan@ncl.ac.uk
RI Siervo, Mario/AAB-9302-2019; Stephan, Blossom/A-1560-2009; Keage,
   Hannah/C-6470-2011
OI Babateen, Abrar/0000-0002-6788-5240; Siervo, Mario/0000-0001-5515-0944;
   Keage, Hannah/0000-0002-6814-4997; Harrison,
   Stephanie/0000-0002-8846-0946
FU National Institute of Health; MRC [MR/N007921/1] Funding Source: UKRI;
   National Institutes of Health Research (NIHR) [NIHR-RP-011-043] Funding
   Source: National Institutes of Health Research (NIHR)
FX Louise Robinson reports grants from the National Institute of Health
   Research Professorship.
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NR 79
TC 56
Z9 69
U1 0
U2 15
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1523-3782
EI 1534-3170
J9 CURR CARDIOL REP
JI Curr. Cardiol. Rep.
PD SEP
PY 2017
VL 19
IS 9
AR 87
DI 10.1007/s11886-017-0898-y
PG 8
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Cardiovascular System & Cardiology
GA FF3AT
UT WOS:000408768600013
PM 28801790
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU da Silva, RMFL
AF Ferreira Lisboa da Silva, Rose Mary
TI Influence of Inflammation and Atherosclerosis in Atrial Fibrillation
SO CURRENT ATHEROSCLEROSIS REPORTS
LA English
DT Review
DE Atherosclerosis; Atrial fibrillation; Inflammation; Cardiovascular
   disease; Thrombogenesis; Lipid profile
ID C-REACTIVE PROTEIN; OXIDATIVE STRESS; CARDIOVASCULAR EVENTS;
   ARTERY-DISEASE; RISK; ASSOCIATION; BIOMARKERS; STROKE; MECHANISMS;
   PRETREATMENT
AB Background Inflammation markers have been associated with cardiovascular diseases including atrial fibrillation. This arrhythmia is the most frequent, with an incidence of 38/1000 person-years.
   Purpose of Review The aims of this study are to discuss the association between inflammation, atherosclerosis and atrial fibrillation and its clinical implications.
   Recent Findings and Summary Atherosclerosis is a chronic inflammatory disease and inflammation is a triggering factor of atherosclerotic plaque rupture. In addition to coronary artery disease, clinical conditions identified as risk factors for atrial fibrillation (AF) are also associated with the inflammatory state such as obesity, diabetes mellitus, hypertension, heart failure, metabolic syndrome and sedentary lifestyle. Biomarkers of inflammation, oxidative stress, coagulation, and myocardial necrosis have been identified in patients with atrial fibrillation and these traditional risk factors. Some markers of inflammation were identified as predictors of recurrence of this arrhythmia, subsequent myocardial infarction, stroke by embolism, and death. Thus, approaches to manipulate the inflammatory pathways may be therapeutic interventions, benefiting patients with AF and increased inflammatory markers.
C1 [Ferreira Lisboa da Silva, Rose Mary] Univ Fed Minas Gerais, Fac Med, Dept Internal Med, Ave Alfredo Balena 190,Room 246, BR-30130100 Belo Horizonte, MG, Brazil.
C3 Universidade Federal de Minas Gerais
RP da Silva, RMFL (corresponding author), Univ Fed Minas Gerais, Fac Med, Dept Internal Med, Ave Alfredo Balena 190,Room 246, BR-30130100 Belo Horizonte, MG, Brazil.
EM roselisboa@uol.com.br
RI Silva, Rose/W-3125-2017
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NR 52
TC 56
Z9 57
U1 1
U2 11
PU CURRENT MEDICINE GROUP
PI PHILADELPHIA
PA 400 MARKET STREET, STE 700, PHILADELPHIA, PA 19106 USA
SN 1523-3804
EI 1534-6242
J9 CURR ATHEROSCLER REP
JI Curr. Atheroscleros. Rep.
PD JAN
PY 2017
VL 19
IS 1
AR 2
DI 10.1007/s11883-017-0639-0
PG 7
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA EK8NE
UT WOS:000394179800002
PM 28102478
DA 2025-06-11
ER

PT J
AU Kurbel, S
AF Kurbel, Sven
TI The renin-angiotensin system in COVID-19: Why ACE2 targeting by
   coronaviruses produces higher mortality in elderly hypertensive
   patients?
SO BIOESSAYS
LA English
DT Article
DE allostasis; arterial hypertension; Corona viruses; renin&#8208;
   angiotensin&#8208; aldosterone system; SARS
ID OCCUPATIONAL NOISE; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   NERVOUS-SYSTEM; STRESS; RECEPTOR; THROMBOSPONDIN-1; NEBIVOLOL;
   RESPONSES; PRORENIN
AB This renin-angiotensin system (RAS) interpretation is focused on differences in tissue dependence on RAS and on the topological hierarchy that allows mediators to act only on downstream tissues.
   Dependence of tissues on RAS: Tested by expectation maximization clustering of the RNA human tissue expression (). ACE and vasoconstrictive AT1R clustered with the prorenin receptor. ACE2 and dilatory MAS1 clustered with nine RAS-related genes, highly expressed in: Liver; Cardiac_Myocytes; Skeletal_Muscle; Uterus; Kidney; Lung; Small_Intestine; Smooth_Muscle.
   RAS and stress accumulation: While prorenin is active after binding to its receptor, binding of soluble renin increases its enzymatic activity several times. Increased renin secretion multiplies the overall capacity for producing Ang I, leading to hypertension and increased vascular resistance.
   Coronavirus infection and comorbidities: Cardiorespiratory failure during infection is linked to the previously altered RAS role in lungs and myocardium. Reduced vasodilation by ACE2 lead to vasoconstriction and suboptimal tissue perfusion patterns.
C1 [Kurbel, Sven] Josip Juraj Strossmayer Univ, Med Fac, J Huttlera 4, Osijek 31000, Croatia.
   [Kurbel, Sven] Juraj Dobrila Univ Pula, Med Fac, Pula, Croatia.
   [Kurbel, Sven] Polyclin Aviva Zagreb, Zagreb, Croatia.
   [Kurbel, Sven] Univ Appl Hlth Sci, Zagreb, Croatia.
C3 University of JJ Strossmayer Osijek; University of Juraj Dobrila Pula;
   University of Applied Health Sciences
RP Kurbel, S (corresponding author), Josip Juraj Strossmayer Univ, Med Fac, J Huttlera 4, Osijek 31000, Croatia.
EM sven@jware.hr
FU Croatian Ministry of Science, Education and Sport; Ministry of Science
   and Technology, Croatia [VIF2018MEFOS02]
FX Croatian Ministry of Science, Education and Sport; Ministry of Science
   and Technology, Croatia, Grant/Award Number: VIF2018MEFOS02
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NR 61
TC 5
Z9 5
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0265-9247
EI 1521-1878
J9 BIOESSAYS
JI Bioessays
PD MAR
PY 2021
VL 43
IS 3
AR 2000112
DI 10.1002/bies.202000112
EA DEC 2020
PG 13
WC Biochemistry & Molecular Biology; Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics
GA QL8HC
UT WOS:000599633700001
PM 33336824
OA Green Published
DA 2025-06-11
ER

PT J
AU Murotomi, K
   Arai, S
   Suyama, A
   Harashima, A
   Nakajima, Y
AF Murotomi, Kazutoshi
   Arai, Shigeyuki
   Suyama, Aki
   Harashima, Akira
   Nakajima, Yoshihiro
TI Trehalose attenuates development of nonalcoholic steatohepatitis
   associated with type 2 diabetes in TSOD mouse
SO JOURNAL OF FUNCTIONAL FOODS
LA English
DT Article
DE Trehalose; Nonalcoholic steatohepatitis; Diabetes; Adipose; Iron; TSOD
   mouse
ID FATTY LIVER-DISEASE; PREVENTS ADIPOCYTE HYPERTROPHY;
   ENDOPLASMIC-RETICULUM STRESS; INSULIN-RESISTANCE; GLUCOSE-TOLERANCE;
   OXIDATIVE STRESS; MODEL; OBESITY; PROGRESSION; INHIBITION
AB Trehalose, a non-reducing disaccharide, induces autophagy. Trehalose mitigates insulin resistance and adipocyte hypertrophy in obese mice; however, its effect on the development of nonalcoholic steatohepatitis (NASH) associated with type 2 diabetes remains unknown. In this study, we investigated the effect of trehalose on the development of NASH in the Tsumura Suzuki Obese Diabetes (TSOD) mouse, a metabolic syndrome model characterized by obesity, type 2 diabetes, and NASH. We found that trehalose intake markedly inhibited histopathological features of NASH, particularly hepatic steatosis and liver cell injury, in TSOD mice. Trehalose intake attenuated increase in mesenteric adipose tissue weight, impaired glucose tolerance, and iron deposition in the duodenum, suggesting that trehalose prevents insulin resistance and iron absorption in TSOD mice. These findings indicate that trehalose attenuates the development of NASH associated with type 2 diabetes, and this attenuation may be mediated by prevention of lipid accumulation and iron absorption.
C1 [Murotomi, Kazutoshi; Nakajima, Yoshihiro] Natl Inst Adv Ind Sci & Technol, Hlth Res Inst, Takamatsu, Kagawa 7610395, Japan.
   [Arai, Shigeyuki; Suyama, Aki; Harashima, Akira] Hayashibara Co Ltd, Naka Ku, Okayama 7028006, Japan.
C3 National Institute of Advanced Industrial Science & Technology (AIST)
RP Murotomi, K (corresponding author), Natl Inst Adv Ind Sci & Technol, Hlth Res Inst, Takamatsu, Kagawa 7610395, Japan.; Arai, S (corresponding author), Hayashibara Co Ltd, Naka Ku, Okayama 7028006, Japan.
EM k-murotomi@aist.go.jp; shigeyuki.arai@hb.nagase.co.jp
RI Murotomi, Kazutoshi/J-1582-2018; Nakajima, Yoshihiro/M-6935-2018
OI Murotomi, Kazutoshi/0000-0002-2124-1538; Nakajima,
   Yoshihiro/0000-0002-7422-730X
FU National Institute of Industrial Science and Technology (AIST)
FX We thank Y. Fujita of AIST for technical support. This research received
   in-house funding from the National Institute of Industrial Science and
   Technology (AIST).
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NR 42
TC 5
Z9 5
U1 0
U2 23
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1756-4646
J9 J FUNCT FOODS
JI J. Funct. Food.
PD MAY
PY 2019
VL 56
BP 303
EP 311
DI 10.1016/j.jff.2019.03.017
PG 9
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA HX6IN
UT WOS:000467507400033
DA 2025-06-11
ER

PT J
AU Jovanovic, I
   Tesic, M
   Giga, V
   Dobric, M
   Boskovic, N
   Vratonjic, J
   Orlic, D
   Gudelj, O
   Tomasevic, M
   Dikic, M
   Nedeljkovic, I
   Trifunovic, D
   Nedeljkovic, MA
   Dedic, S
   Beleslin, B
   Djordjevic-Dikic, A
AF Jovanovic, Ivana
   Tesic, Milorad
   Giga, Vojislav
   Dobric, Milan
   Boskovic, Nikola
   Vratonjic, Jelena
   Orlic, Dejan
   Gudelj, Ognjen
   Tomasevic, Miloje
   Dikic, Miodrag
   Nedeljkovic, Ivana
   Trifunovic, Danijela
   Nedeljkovic, Milan A.
   Dedic, Srdjan
   Beleslin, Branko
   Djordjevic-Dikic, Ana
TI Impairment of coronary flow velocity reserve and global longitudinal
   strain in women with cardiac syndrome X and slow coronary flow
SO JOURNAL OF CARDIOLOGY
LA English
DT Article
DE Cardiac syndrome X; Slow coronary flow; Coronary flow velocity reserve;
   Left ventricular global longitudinal strain; Microvascular dysfunction
ID MICROVASCULAR DYSFUNCTION; EUROPEAN ASSOCIATION; AMERICAN SOCIETY;
   STRESS ECHOCARDIOGRAPHY; MYOCARDIAL STRAIN; ANGINA-PECTORIS;
   ARTERY-DISEASE; HEART-FAILURE; BLOOD-FLOW; RECOMMENDATIONS
AB Background: Microvascular dysfunction (MVD) is associated with adverse prognosis and may account for abnormal stress tests and angina symptoms in women with cardiac syndrome X (CSX). The aim of our study was to assess MVD by coronary flow velocity reserve (CFVR) and left ventricular (LV) contractile function by LV global longitudinal strain (LVGLS) in CSX patients with respect to presence of slow coronary flow (SCF). It was of additional importance to evaluate clinical status of CSX patients using Seattle Angina Questionnaire.
   Methods and results: Study population included 70 women with CSX (mean age 61 +/- 7 years) and 34 age-matched controls. CSX group was stratified into two subgroups depending on SCF presence: CSX-Thrombolysis In Myocardial Infarction (TIMI) 3-normal flow subgroup (n = 38) and CSX-TIMI 2-SCF subgroup (n = 32) as defined by coronary angiography. LVGLS measurements and CFVR of left anterior descending (LAD) and posterior descending (PD) artery were performed. CFVR-LAD and PD were markedly impaired in CSX group compared to controls (2.34 + 0.25 vs 3.05 + 0.21, p < 0.001; 2.32 + 0.24 vs 3.01 +/- 0.13, p < 0.001), and furthermore decreased in CSX-TIMI 2 patients. Resting, peak, and DLVGLS were all significantly impaired in CSX group compared to controls (for all p < 0.001), and furthermore reduced in CSX-TIMI 2 subgroup. Strongest correlation was found between peak LVGLS and CFVR LAD (r = -0.784, p < 0.001) and PD (r = -0.772, p < 0.001). CSX-TIMI 2 subgroup had more frequent angina symptoms and more impaired quality of life.
   Conclusions: MVD in CSX patients is demonstrated by reduction in CFVR and LVGLS values. SCF implies more profound impairment of microvascular and LV systolic function along with worse clinical presentation. (C) 2020 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved.
C1 [Jovanovic, Ivana; Tesic, Milorad; Giga, Vojislav; Dobric, Milan; Boskovic, Nikola; Vratonjic, Jelena; Orlic, Dejan; Tomasevic, Miloje; Dikic, Miodrag; Nedeljkovic, Ivana; Trifunovic, Danijela; Nedeljkovic, Milan A.; Dedic, Srdjan; Beleslin, Branko; Djordjevic-Dikic, Ana] Clin Ctr Serbia, Clin Cardiol, Visegradska 26, Belgrade 11000, Serbia.
   [Tesic, Milorad; Giga, Vojislav; Dobric, Milan; Orlic, Dejan; Nedeljkovic, Ivana; Trifunovic, Danijela; Nedeljkovic, Milan A.; Beleslin, Branko; Djordjevic-Dikic, Ana] Univ Belgrade, Sch Med, Belgrade, Serbia.
   [Gudelj, Ognjen] Mil Med Acad, Clin Cardiol, Belgrade, Serbia.
   [Tomasevic, Miloje] Univ Kragujevac, Sch Med, Kragujevac, Serbia.
C3 Clinical Centre of Serbia; University of Belgrade; University of
   Kragujevac
RP Jovanovic, I (corresponding author), Clin Ctr Serbia, Clin Cardiol, Visegradska 26, Belgrade 11000, Serbia.
EM ivana170679@gmail.com
RI Nedeljkovic, Ivana/B-3815-2013; Nedeljkovic, Milan/JNT-4485-2023
OI Jovanovic, Ivana/0000-0001-8036-6560; Dobric, Milan/0000-0001-7643-0451;
   Tesic, Milorad/0000-0002-3758-3719; Giga, Vojislav/0000-0003-1049-6321;
   Boskovic, Nikola/0000-0001-8987-4190; Nedeljkovic,
   Ivana/0000-0001-5552-773X; Orlic, Dejan/0009-0004-6030-9322
FU Ministry of Education, Science and Technological Development of the
   Republic of Serbia [III41022, ON175020]
FX This study was partially supported by the grants of the Ministry of
   Education, Science and Technological Development of the Republic of
   Serbia (grant numbers III41022 and ON175020).
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NR 42
TC 14
Z9 18
U1 0
U2 4
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0914-5087
EI 1876-4738
J9 J CARDIOL
JI J. Cardiol.
PD JUL
PY 2020
VL 76
IS 1
BP 1
EP 8
DI 10.1016/j.jjcc.2020.02.005
PG 8
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA LS3OV
UT WOS:000536298200006
PM 32387219
OA Bronze
DA 2025-06-11
ER

PT J
AU Kamiya, A
   Ida, K
AF Kamiya, Akihide
   Ida, Kinuyo
TI Liver Injury and Cell Survival in Non-Alcoholic Steatohepatitis
   Regulated by Sex-Based Difference through B Cell Lymphoma 6
SO CELLS
LA English
DT Review
DE non-alcoholic steatohepatitis; non-alcoholic fatty liver disease;
   inflammation
ID ESTROGEN-RECEPTOR-ALPHA; FATTY LIVER; TRANSCRIPTIONAL REGULATION;
   VITAMIN-E; DISEASE; GENE; INFLAMMATION; EXPRESSION; DIMORPHISM;
   DYSBIOSIS
AB The liver is a crucial organ for maintaining homeostasis in living organisms and is the center of various metabolic functions. Therefore, abnormal metabolic activity, as in metabolic syndrome, leads to pathological conditions, such as abnormal accumulation of lipids in the liver. Inflammation and cell death are induced by several stresses in the fatty liver, namely steatohepatitis. In recent years, an increase in non-alcoholic steatohepatitis (NASH), which is not dependent on excessive alcohol intake, has become an issue as a major cause of liver cirrhosis and liver cancer. There are several recent findings on functional sex-based differences, NASH, and cell stress and death in the liver. In particular, NASH-induced liver injury and tumorigeneses were suppressed by B cell lymphoma 6, the transcriptional factor regulating sex-based liver functional gene expression. In this review, we discuss cell response to stress and lipotoxicity in NASH and its regulatory mechanisms.
C1 [Kamiya, Akihide; Ida, Kinuyo] Tokai Univ, Dept Mol Life Sci, Sch Med, 143 Shimokasuya, Isehara 2591193, Japan.
C3 Tokai University
RP Kamiya, A (corresponding author), Tokai Univ, Dept Mol Life Sci, Sch Med, 143 Shimokasuya, Isehara 2591193, Japan.
EM kamiyaa@tokai-u.jp
FU Ministry of Education, Culture, Sports and Technology, Japan [20H04931];
   Tokai University School of Medicine;  [19H03643]
FX This study was supported in part by a Grant-in-Aid for Scientific
   Research from the Ministry of Education, Culture, Sports and Technology,
   Japan (19H03643 and 20H04931). This study was also supported in part by
   2022~2023 Tokai University School of Medicine, Project Research (to AK).
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NR 65
TC 2
Z9 2
U1 0
U2 3
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2073-4409
J9 CELLS-BASEL
JI Cells
PD DEC
PY 2022
VL 11
IS 23
AR 3751
DI 10.3390/cells11233751
PG 11
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA 6Y9OI
UT WOS:000897415000001
PM 36497010
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Johnson, RJ
   Gaucher, EA
   Sautin, YY
   Henderson, GN
   Angerhofer, AJ
   Benner, SA
AF Johnson, Richard J.
   Gaucher, Eric A.
   Sautin, Yuri Y.
   Henderson, George N.
   Angerhofer, Alex J.
   Benner, Steven A.
TI The planetary biology of ascorbate and uric acid and their relationship
   with the epidemic of obesity and cardiovascular disease
SO MEDICAL HYPOTHESES
LA English
DT Article
ID VITAMIN-C SUPPLEMENTATION; GAMMA-LACTONE OXIDASE; BLOOD-PRESSURE;
   OXIDATIVE STRESS; URATE OXIDASE; ESSENTIAL-HYPERTENSION;
   CELL-PROLIFERATION; NONFUNCTIONAL GENE; HOMINOID EVOLUTION; METABOLIC
   SYNDROME
AB Humans have relatively low plasma ascorbate levels and high serum uric acid levels compared to most mammals due to the presence of genetic mutations in L-gulonotactone oxidase and uricase, respectively. We review the major hypotheses for why these mutations may have occurred. In particular, we suggest that both mutations may have provided a survival advantage to early primates by helping maintain blood pressure during periods of dietary change and environmental stress. We further propose that these mutations have the inadvertent disadvantage of increasing our risk for hypertension and cardiovascular disease in today's society characterized by Western diet and increasing physical inactivity. Finally, we suggest that a "planetary biology" approach in which genetic changes are analyzed in relation to their biological action and historical context may provide the ideal approach towards understanding the biology of the past, present and future. (c) 2008 Elsevier Ltd. All rights reserved.
C1 Univ Florida, Div Nephrol Hypertens & Transplantat, Gainesville, FL 32610 USA.
   Fdn Appl Mol Evolut, Gainesville, FL 32610 USA.
C3 State University System of Florida; University of Florida
RP Johnson, RJ (corresponding author), Univ Florida, Div Nephrol Hypertens & Transplantat, Gainesville, FL 32610 USA.
EM johnsrj@medicine.ufl.edu
RI Gaucher, Eric/I-7313-2013; Angerhofer, Alexander/E-3143-2010
OI Angerhofer, Alexander/0000-0002-8580-6024
FU NHLBI NIH HHS [R01 HL068607, HL-68607, R01 HL079352] Funding Source:
   Medline; NIDDK NIH HHS [R01 DK052121, DK-52121] Funding Source: Medline
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NR 95
TC 62
Z9 69
U1 0
U2 7
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0306-9877
EI 1532-2777
J9 MED HYPOTHESES
JI Med. Hypotheses
PY 2008
VL 71
IS 1
BP 22
EP 31
DI 10.1016/j.mehy.2008.01.017
PG 10
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 316XK
UT WOS:000256982800005
PM 18331782
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Drvar, V
   Legovic, D
   Juresic, GA
   Curko-Cofek, B
   Kehler, T
   Laskarin, AM
   Nemcic, E
   Laskarin, G
AF Drvar, Vedrana
   Legovic, Dalen
   Juresic, Gordana Anadi
   Curko-Cofek, Bozena
   Kehler, Tatjana
   Laskarin, Ana-Marija
   Nemcic, Emilio
   Laskarin, Gordana
TI Possible immune mechanisms initiated by 7-ketocholesterol that
   contribute to synovial oxidative stress and inflammation
SO MEDICAL HYPOTHESES
LA English
DT Article
DE CD68; 7-Ketocholesterol; Macrophages; Macrophage polarization;
   Osteoarthritis; Synovial tissue
ID LOW-DENSITY-LIPOPROTEIN; NECROSIS-FACTOR-ALPHA; RHEUMATOID-ARTHRITIS;
   MACROPHAGE PLASTICITY; METABOLIC SYNDROME; IN-VITRO; KAPPA-B;
   OSTEOARTHRITIS; EXPRESSION; CELLS
AB Osteoarthritis (OA) is a chronic joint disease caused by both mechanical damage and metabolic factors, which intertwine in their pathogenetic pathways. We hypothesise that the oxidised cholesterol derivative, 7-ketocholes-terol (7-KCh), represents a danger signal in the synovia of patients with OA and promotes low-grade inflam-mation. The study would aim to elucidate the possible immune mechanisms initiated by 7-KCh that contribute to oxidative stress and inflammation in the synovia and synovial CD68+ cells, which are mostly macrophages. The polarisation of synovial CD68+ cells, their tissue distribution in relation to T and natural killer (NK) cells, and the influence of 7-KCh on the phenotype and intracellular cytokine and chemokine production in suspension is worth analysing. We envisage that this research would contribute to a better understanding of the biology of CD68+ macrophages influenced by 7-KCh and encourage the development of therapeutic approaches based on directing macrophage polarisation.
C1 [Drvar, Vedrana] Clin Hosp Ctr Rijeka, Clin Dept Lab Diagnost, Tome Striz 3, Rijeka 51000, Croatia.
   [Legovic, Dalen] Orthopaed Hosp Lovran, Setaliste marsala Tita 1, Lovran 51415, Croatia.
   [Juresic, Gordana Anadi] Univ Rijeka, Fac Med, Dept Med Chem Biochem & Clin Chem, B Branchetta 20, Rijeka 51000, Croatia.
   [Curko-Cofek, Bozena; Laskarin, Gordana] Univ Rijeka, Fac Med, Dept Physiol Immunol & Pathophysiol, B Branchetta 20, Rijeka 51000, Croatia.
   [Kehler, Tatjana; Laskarin, Gordana] Special Hosp Med Rehabil Hearth & Lung Dis & Rheum, M Tita 188, Opatija 51410, Croatia.
   [Laskarin, Ana-Marija] Univ Zagreb, Sch Dent Med, Gunduliceva 5, Zagreb 10000, Croatia.
   [Nemcic, Emilio] Inst Emergency Med Koprivnica Krizevac Cty, Trg Tomislava Bardeka 10, Koprivnica 48000, Croatia.
C3 University of Rijeka; University of Rijeka; University of Rijeka;
   University of Zagreb; University of Zagreb, School of Dental Medicine
RP Drvar, V (corresponding author), Clin Hosp Ctr Rijeka, Clin Dept Lab Diagnost, Tome Striz 3, Rijeka 51000, Croatia.
EM vedrana.drvar@student.uniri.hr
RI Legović, Dalen/JPF-5298-2023; Kehler, Tatjana/MVT-7655-2025;
   Ćurko-Cofek, Božena/O-3244-2018; Laskarin, Ana'Marija/MTP-3215-2025;
   Laskarin, Gordana/O-6972-2018; Drvar, Vedrana/JPK-5572-2023; Canadi
   Juresic, Gordana/R-8923-2018
OI Drvar, Vedrana/0000-0002-4011-856X; Canadi Juresic,
   Gordana/0000-0003-0128-4634
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NR 60
TC 0
Z9 0
U1 1
U2 4
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0306-9877
EI 1532-2777
J9 MED HYPOTHESES
JI Med. Hypotheses
PD JUN
PY 2023
VL 175
AR 111078
DI 10.1016/j.mehy.2023.111078
EA APR 2023
PG 6
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA F8AZ7
UT WOS:000984533100001
DA 2025-06-11
ER

PT J
AU Rapin, JR
   Wiernsperger, N
AF Rapin, Jean Robert
   Wiernsperger, Nicolas
TI POSSIBLE LINKS BETWEEN INTESTINAL PERMEABLITY AND FOOD PROCESSING: A
   POTENTIAL THERAPEUTIC NICHE FOR GLUTAMINE
SO CLINICS
LA English
DT Article
DE Intestinal permeability; Glycation; Allergy; Metabolic syndrome;
   Glutamine; Curcumin
ID GLYCATION END-PRODUCTS; INFLAMMATORY-BOWEL-DISEASE; MAILLARD
   REACTION-PRODUCTS; FRUCTOSE CORN SYRUP; INCREASED GUT PERMEABILITY;
   BARRIER FUNCTION; DIETARY FRUCTOSE; INSULIN-RESISTANCE; OXIDATIVE
   STRESS; TIGHT JUNCTIONS
AB Increased intestinal permeability is a likely cause of various pathologies, such as allergies and metabolic or even cardiovascular disturbances. Intestinal permeability is found in many severe clinical situations and in common disorders such as irritable bowel syndrome. In these conditions, substances that are normally unable to cross the epithelial barrier gain access to the systemic circulation. To illustrate the potential harmfulness of leaky gut, we present an argument based on examples linked to protein or lipid glycation induced by modern food processing. Increased intestinal permeability should be largely improved by dietary addition of compounds, such as glutamine or curcumin, which both have the mechanistic potential to inhibit the inflammation and oxidative stress linked to tight junction opening. This brief review aims to increase physician awareness of this common, albeit largely unrecognized, pathology, which may be easily prevented or improved by means of simple nutritional changes.
C1 [Rapin, Jean Robert] Univ Burgundy, Fac Pharm, Dijon, France.
   [Wiernsperger, Nicolas] INSERM, Villeurbanne, France.
   [Rapin, Jean Robert; Wiernsperger, Nicolas] Assoc REMEDES, Orlienas, France.
C3 Universite Bourgogne Europe; Institut National de la Sante et de la
   Recherche Medicale (Inserm)
RP Rapin, JR (corresponding author), Univ Burgundy, Fac Pharm, Dijon, France.
EM jeanrobert.rapin@gmail.com
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NR 140
TC 37
Z9 43
U1 0
U2 43
PU HOSPITAL CLINICAS, UNIV SAO PAULO
PI SAO PAULO
PA FAC MEDICINA, UNIV SAO PAULO, SAO PAULO, SP 00000, BRAZIL
SN 1807-5932
EI 1980-5322
J9 CLINICS
JI Clinics
PD JUN
PY 2010
VL 65
IS 6
BP 635
EP 643
DI 10.1590/S1807-59322010000600012
PG 9
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 628TD
UT WOS:000280143700012
PM 20613941
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Xie, H
   Liu, X
   Li, S
   Wang, M
   Li, Y
   Chen, T
   Li, LW
   Wang, FX
   Xiao, X
AF Xie, Hao
   Liu, Xin
   Li, Shuo
   Wang, Ming
   Li, Ying
   Chen, Ting
   Li, Linwei
   Wang, Faxi
   Xiao, Xuan
TI Tissue adaptation to metabolic stress: insights from SUMOylation
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Review
DE post-translational modification; SUMOylation; metabolic homeostasis;
   obesity; insulin resistance
ID CONJUGATING ENZYME UBC9; ADIPOSE-TISSUE; PROTEIN MODIFICATION;
   LIPID-METABOLISM; SKELETAL-MUSCLE; PPAR-ALPHA; BROWN; EXPRESSION; SENP2;
   CELLS
AB Post-translational modification (PTM) plays a crucial role in adaptation of mammals to environmental changes, enabling them to survive in stressful situations. One such PTM is SUMO modification, which is evolutionarily conserved. It involves the covalent and reversible attachment of a small ubiquitin-like modifier (SUMO) to lysine (Lys) residues in the target protein. SUMOylation regulates various functions, including cell proliferation, differentiation, apoptosis, senescence, and maintenance of specific cellular activities. It achieves this by influencing protein-protein interactions, subcellular localization, protein stability, and DNA binding activity. Mounting evidence suggests that SUMOylation is implicated in the pathogenesis of metabolic disorders such as obesity, insulin resistance, and fatty liver. This review aims to provide an overview of the role of SUMOylation in regulating tissue adaptation to metabolic stress. Recent advancements in spectroscopic techniques have shed light on potential targets of SUMOylation and the underlying regulatory mechanisms have been elucidated, laying the theoretical foundation for the development of targeted SUMOylation interventions for metabolic syndrome while minimizing side effects.
C1 [Xie, Hao; Li, Shuo; Wang, Ming; Wang, Faxi; Xiao, Xuan] Wuhan Univ, Inst Translat Med, Dept Clin Lab, Renmin Hosp, Wuhan, Hubei, Peoples R China.
   [Liu, Xin] Wuhan Univ, Dept Intervent Radiol, Renmin Hosp, Wuhan, Hubei, Peoples R China.
   [Li, Ying; Chen, Ting; Li, Linwei; Xiao, Xuan] Wuhan Univ, Dept Ophthalmol, Renmin Hosp, Wuhan, Hubei, Peoples R China.
C3 Wuhan University; Wuhan University; Wuhan University
RP Wang, FX; Xiao, X (corresponding author), Wuhan Univ, Inst Translat Med, Dept Clin Lab, Renmin Hosp, Wuhan, Hubei, Peoples R China.; Xiao, X (corresponding author), Wuhan Univ, Dept Ophthalmol, Renmin Hosp, Wuhan, Hubei, Peoples R China.
EM faxiwang@163.com; xiaoxuan1111@whu.edu.cn
RI Wang, Ming/AAM-3842-2021; Wang, Faxi/JRY-6462-2023; Li,
   Linwei/JAD-0802-2023; Xie, Hao/MFJ-3720-2025
OI Wang, Faxi/0000-0003-3772-6692
FU National Natural Science Foundation of China [82371079, 82100823,
   82401273]; Key research and development project of Hubei Province
   [2022BCA009]; Wuhan University Specific Fund for Major School-level
   Internationalization Initiatives [WHU-GJZDZX-PT02]; Translational
   medicine Project of Hubei Provincial Health Commission [WJ2021ZH0015];
   Fundamental Research Funds for the Central Universities [2042021kf0085,
   2042022gf0006]
FX The author(s) declare financial support was received for the research,
   authorship, and/or publication of this article. This study was supported
   by the National Natural Science Foundation of China (82371079, 82100823,
   82401273), the Key research and development project of Hubei Province
   (2022BCA009), Wuhan University Specific Fund for Major School-level
   Internationalization Initiatives (WHU-GJZDZX-PT02), Translational
   medicine Project of Hubei Provincial Health Commission (WJ2021ZH0015),
   Fundamental Research Funds for the Central Universities (2042021kf0085
   and 2042022gf0006).
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NR 154
TC 1
Z9 1
U1 1
U2 1
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD NOV 11
PY 2024
VL 15
AR 1434338
DI 10.3389/fendo.2024.1434338
PG 13
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA N1A6B
UT WOS:001361743500001
PM 39588331
OA gold
DA 2025-06-11
ER

PT J
AU Qin, ZW
   Yang, H
   Liu, JL
   Li, DX
   Wang, Y
   Chen, YJ
   Huang, CJ
AF Qin, Ziwen
   Yang, Hong
   Liu, Junli
   Li, Dongxiao
   Wang, Yue
   Chen, Yujuan
   Huang, Chuanjun
TI Obesity alters inflammatory response in the pathology of asthma (Review)
SO INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
LA English
DT Review
DE obesity-related asthma; immune response; airway inflammation; body mass
   index; airway hyperresponsiveness; T helper 2; high-fat diet; reactive
   oxygen species; nitric oxide
ID INNATE LYMPHOID-CELLS; INDUCED AIRWAY INFLAMMATION; ADIPOSE-TISSUE
   DYSFUNCTION; BODY-MASS INDEX; OXIDATIVE STRESS; WEIGHT-LOSS;
   DOUBLE-BLIND; INSULIN-RESISTANCE; METABOLIC SYNDROME; LUNG-FUNCTION
AB Obesity is one of the comorbidities in patients with asthma and obese patients with asthma present with a distinct phenotype with more severe disease outcomes and reduced responsiveness to standard therapies. Although the full mechanisms of obesity-related asthma are still not completely understood, abnormal immune responses have been demonstrated to have a critical role in asthma pathogenesis. The present review summarizes the data from clinical, epidemiological and animal studies to provide an updated understanding of the immune responses in obesity-related asthma, as well as the effect of various factors, such as oxidative stress, mitochondrial dysfunction, genetics and epigenetics, on asthmatic inflammation. Further studies on the in-depth mechanisms are still required to develop novel preventive and therapeutic strategies for patients with asthma combined with obesity.
C1 [Qin, Ziwen; Wang, Yue] Shandong Univ Tradit Chinese Med, Clin Med Coll 1, Jinan 250014, Shandong, Peoples R China.
   [Yang, Hong] Qingdao Tradit Chinese Med Hosp, Qingdao Hiser Hosp, Dept Nutr, Qingdao 266033, Shandong, Peoples R China.
   [Yang, Hong] Qingdao Univ, Dept Nutr, Qingdao Hiser Hosp, Qingdao 266033, Shandong, Peoples R China.
   [Liu, Junli] Shandong Univ Tradit Chinese Med, Dept Community Management, Affiliated Hosp 2, Jinan 250001, Shandong, Peoples R China.
   [Li, Dongxiao; Chen, Yujuan] Shandong Univ Tradit Chinese Med, Expt Ctr, 4655 Univ Ave, Jinan 250355, Shandong, Peoples R China.
   [Huang, Chuanjun] Shandong First Med Univ, Dept Resp Dis, Shandong Prov Hosp, 324 Jingwu Weiqi Rd, Jinan 250021, Shandong, Peoples R China.
C3 Shandong University of Traditional Chinese Medicine; Qingdao University;
   Shandong University of Traditional Chinese Medicine; Shandong University
   of Traditional Chinese Medicine; Shandong First Medical University &
   Shandong Academy of Medical Sciences
RP Chen, YJ (corresponding author), Shandong Univ Tradit Chinese Med, Expt Ctr, 4655 Univ Ave, Jinan 250355, Shandong, Peoples R China.; Huang, CJ (corresponding author), Shandong First Med Univ, Dept Resp Dis, Shandong Prov Hosp, 324 Jingwu Weiqi Rd, Jinan 250021, Shandong, Peoples R China.
EM chenyujuan66@163.com; elisandread@gmail.com
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NR 165
TC 2
Z9 2
U1 0
U2 7
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1107-3756
EI 1791-244X
J9 INT J MOL MED
JI Int. J. Mol. Med.
PD JUL
PY 2023
VL 52
IS 1
AR 63
DI 10.3892/ijmm.2023.5266
PG 15
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA J2PN0
UT WOS:001008082100001
PM 37293862
DA 2025-06-11
ER

PT J
AU Das, A
AF Das, Aniruddha
TI Spousal Loss and Health in Late Life: Moving Beyond Emotional Trauma
SO JOURNAL OF AGING AND HEALTH
LA English
DT Article
DE spousal loss; late life; stress process; weathering
ID GENDER-DIFFERENCES; OLDER-ADULTS; PSYCHOLOGICAL DISTRESS;
   CARDIOVASCULAR-DISEASE; DEPRESSIVE SYMPTOMS; MARITAL DISRUPTION;
   ETHNIC-DIFFERENCES; METABOLIC SYNDROME; CIGARETTE-SMOKING; FUNCTIONAL
   STATUS
AB Objectives: This study queries the linkage of older adults' spousal loss to multiple dimensions of their health. Methods: Data are from the 2005-2006 National Social Life, Health, and Aging Project, nationally representative of U.S. adults ages 57 to 85. Analyses examine associations of spousal loss and time since loss with multiple health dimensions. Results: Spousal loss is linked to a system of mental, social, behavioral, and biological issues, consistent with a stress-induced weathering process. Biological problems are more uniformly associated with women's than men's loss. While emotional sequelae may partially subside with time, a range of other outcomes remain worse even among individuals a decade or more past loss, than those with current partners. Discussion: Older adults' spousal loss influences multiple dimensions of their health. Gender differences in biological linkages suggest women's greater physiological vulnerability to this weathering event. Effects of loss are long term rather than transient, especially with biological conditions.
C1 [Das, Aniruddha] McGill Univ, Montreal, PQ H3A 2T7, Canada.
C3 McGill University
RP Das, A (corresponding author), McGill Univ, Dept Sociol, Leacock 712,855 Sherbrooke St W, Montreal, PQ H3A 2T7, Canada.
EM aniruddha.das@mcgill.ca
FU NIA NIH HHS [R37 AG030481, R01 AG021487, R01-AG021487, R01 AG033903,
   R37-AG030481, R01-AG033903] Funding Source: Medline
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NR 78
TC 57
Z9 62
U1 0
U2 30
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0898-2643
EI 1552-6887
J9 J AGING HEALTH
JI J. Aging Health
PD MAR
PY 2013
VL 25
IS 2
BP 221
EP 242
DI 10.1177/0898264312464498
PG 22
WC Gerontology; Health Policy & Services
WE Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Health Care Sciences & Services
GA 087NV
UT WOS:000314769500002
PM 23271727
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Castro, RI
   Forero-Doria, O
   Soto-Cerda, L
   Peña-Neira, A
   Guzmán, L
AF Castro, Ricardo, I
   Forero-Doria, Oscar
   Soto-Cerda, Luis
   Pena-Neira, A.
   Guzman, Luis
TI Protective Effect of Pitao (Pitavia punctata R. & P.)
   Molina ) Polyphenols against the Red Blood Cells Lipoperoxidation and
   the In Vitro LDL Oxidation
SO EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Article
ID LOW-DENSITY-LIPOPROTEIN; ANTIOXIDANT ACTIVITY; NITRIC-OXIDE; POTENTIAL
   ANTIOXIDANT; CYMBOPOGON-CITRATUS; METABOLIC SYNDROME; QUERCETIN; DAMAGE;
   FLAVONOIDS; ACIDS
AB The oxidative stress is characterized by an imbalance between the oxidizing agents and antioxidants; meanwhile, the consumption of antioxidants has been considered as an important tool in the prevention of oxidative stress and its consequences. Pitavia punctata (R. & P.) Molina is an endemic arboreal species from the Chilean Coast Range, in which a large amount of flavonoids has been described. This work foc used on characterizing and evaluating, in human erythrocytes, the antioxidant capacity and membrane protection of P punctata extracts and the in vitro protection of the oxidation of the Low Density Lipoprotein (LDL). The phytochemical screening revealed the presence of Quercetin derivatives and flavonoids, such as (-)-Epicatechin, Kaempferol, and derivatives. The methanolic extract presented an important antioxidant activity, protecting the membrane integrity of the red blood cells against the oxidative damage caused by Hypochlorous acid and inhibiting the oxidation of the LDL lipoprotein.
C1 [Castro, Ricardo, I] Univ Autonoma Chile, Multidisciplinary Agroind Res Lab, Talca, Chile.
   [Castro, Ricardo, I] Univ Autonoma Chile, Carrera Ingn Construct, Talca, Chile.
   [Castro, Ricardo, I] Univ Autonoma Chile, Inst Ciencias Biomed, Talca, Chile.
   [Forero-Doria, Oscar] Univ Talca, Inst Quim Recursos Nat, Talca, Chile.
   [Soto-Cerda, Luis] Univ Talca, Fac Ciencias Forestales, Talca, Chile.
   [Soto-Cerda, Luis] Univ Talca, Ctr Plantas Nativas Chile CENATIV, Talca, Chile.
   [Pena-Neira, A.] Univ Chile, Fac Agron Sci, Dept Agroind & Enol, POB 1004, Santiago, Chile.
   [Guzman, Luis] Univ Talca, Fac Ciencias Salud, Dept Bioquim Clin & Inmunohematol, Talca, Chile.
C3 Universidad Autonoma de Chile; Universidad Autonoma de Chile;
   Universidad Autonoma de Chile; Universidad de Talca; Universidad de
   Talca; Universidad de Talca; Universidad de Chile; Universidad de Talca
RP Guzmán, L (corresponding author), Univ Talca, Fac Ciencias Salud, Dept Bioquim Clin & Inmunohematol, Talca, Chile.
EM lguzman@utalca.cl
RI Castro, Ricardo/HPD-5729-2023; Guzmán, Luis/HLH-3515-2023; Doria,
   Oscar/ABF-7089-2020; Pena Neira, Alvaro/I-2793-2013
OI Castro, Ricardo/0000-0002-8054-1469; Forero Doria, Oscar
   Javier/0000-0002-6770-5406; Soto-Cerda, Luis/0009-0006-6341-8991; Pena
   Neira, Alvaro/0000-0003-1605-4241; Guzman, Luis/0000-0003-1552-7430
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NR 52
TC 2
Z9 2
U1 0
U2 8
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1741-427X
EI 1741-4288
J9 EVID-BASED COMPL ALT
JI Evid.-based Complement Altern. Med.
PY 2018
VL 2018
AR 1049234
DI 10.1155/2018/1049234
PG 9
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA GQ3PN
UT WOS:000441578800001
PM 30151018
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Matsui, T
   Nishino, Y
   Ojima, A
   Maeda, S
   Tahara, N
   Yamagishi, S
AF Matsui, Takanori
   Nishino, Yuri
   Ojima, Ayako
   Maeda, Sayaka
   Tahara, Nobuhiro
   Yamagishi, Sho-ichi
TI Pigment Epithelium-Derived Factor Improves Metabolic Derangements and
   Ameliorates Dysregulation of Adipocytokines in Obese Type 2 Diabetic
   Rats
SO AMERICAN JOURNAL OF PATHOLOGY
LA English
DT Article
ID FACTOR PEDF; INSULIN-RESISTANCE; ENDOTHELIAL-CELLS; SERUM-LEVELS;
   RECEPTOR; LEVEL
AB Oxidative stress and inflammation in the adipose tissues contribute to the metabolic syndrome. Pigment epithelium-derived factor (PEDF) inhibits vascular inflammation through its anti-oxidative properties. However, it remains unclear whether PEDF could suppress adipocyte inflammation. We investigated the effects of tong-term administration or suppression of PEDF on adipocyte inflammation and metabolic derangements in Otsuka Long-Evans Tokushima Fatty (OLETF) rats, an animal model of type 2 diabetes with insulin resistance. Circulating and adipose tissue PEDF levels were increased as OLETF rats became more obese and insulin resistant. Long-term administration of PEDF improves metabolic parameters, ameliorates dysregulation of adipocytokines, and suppresses NADPH oxidase-induced oxidative stress and macrophage infiltration in the adipose tissues of OLETF rats, whereas these variables are exacerbated by the knockdown of PEDF by administering siRNAs. Our study suggests that PEDF could improve metabolic derangements by suppressing the inflammatory and oxidative reactions in adipose tissues of OLETF rats. PEDF levels may be elevated as a countersystem against obesity-related metabolic derangements.
C1 [Matsui, Takanori; Nishino, Yuri; Ojima, Ayako; Maeda, Sayaka; Yamagishi, Sho-ichi] Kurume Univ, Sch Med, Dept Pathophysiol & Therapeut Diabet Vasc Complic, Kurume, Fukuoka 8300011, Japan.
   [Tahara, Nobuhiro] Kurume Univ, Sch Med, Dept Med, Div Cardiovasc Med, Kurume, Fukuoka 8300011, Japan.
C3 Kurume University; Kurume University
RP Yamagishi, S (corresponding author), Kurume Univ, Sch Med, Dept Pathophysiol & Therapeut Diabet Vasc Complic, 67 Asahi Machi, Kurume, Fukuoka 8300011, Japan.
EM shoichi@med.kurume-u.ac.jp
RI Nishino, Yuri/LBH-7945-2024
OI Matsui, Takanori/0000-0001-9506-7571
FU Ministry of Education, Culture, Sports, Science and Technology, Japan;
   Ministry of Education, Culture, Sports, Science and Technology;
   Grants-in-Aid for Scientific Research [23591072] Funding Source: KAKEN
FX Supported, in part, by the Ministry of Education, Culture, Sports,
   Science and Technology, Japan, Grants-in-Aid for Scientific Research (B)
   and the Ministry of Education, Culture, Sports, Science and
   Technology-Supported Program for the Strategic Research Foundation at
   Private Universities (S.Y.).
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NR 32
TC 24
Z9 28
U1 0
U2 7
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0002-9440
EI 1525-2191
J9 AM J PATHOL
JI Am. J. Pathol.
PD APR
PY 2014
VL 184
IS 4
BP 1094
EP 1103
DI 10.1016/j.ajpath.2013.12.032
PG 10
WC Pathology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pathology
GA AD8XI
UT WOS:000333548600021
PM 24530621
DA 2025-06-11
ER

PT J
AU Baffy, G
AF Baffy, Gyoergy
TI Allostasis in Nonalcoholic Fatty Liver Disease: Implications for Risk
   Assessment
SO DIGESTIVE DISEASES AND SCIENCES
LA English
DT Review
DE Allostasis; Allostatic load; Outcomes; Risk prediction; Allostatic
   score; Nonalcoholic fatty liver disease; Hepatocellular carcinoma
ID HEPATOCELLULAR-CARCINOMA; INSULIN-RESISTANCE; METABOLIC-SYNDROME;
   STRESS; LIPOTOXICITY; OBESITY; STEATOHEPATITIS; LIPOGENESIS; ADAPTATION;
   MECHANISMS
AB Allostasis, a concept of anticipatory physiological regulation in response to external and internal challenges, was originally developed in the context of neuroendocrinology and behavioral medicine. Allostasis preserves function under changing conditions by abandoning physiological set points and developing new ones. Allostatic load refers to the aggregate effect of adaptation throughout life, and corresponds to the wear and tear associated with this process. In response to chronic stress, allostatic load may accumulate faster than expected if sustained activation of regulatory systems exceeds optimum operating ranges; this results in increased risk of disease. Used in a broader sense, the allostatic model of adaptive responses, trade-offs, feed-forward cycles, and collateral damage provides a framework for assessing the involvement of environmental-genetic interactions and co-morbidities in the course of chronic disease and developing a comprehensive score for personalized risk prediction. The utility of this approach is illustrated for nonalcoholic fatty liver disease, a prevalent condition with common and less common outcomes.
C1 [Baffy, Gyoergy] VA Boston Healthcare Syst, Dept Med, Boston, MA 02130 USA.
   [Baffy, Gyoergy] Harvard Univ, Brigham & Womens Hosp, Sch Med, Boston, MA 02115 USA.
   [Baffy, Gyoergy] VA Boston Healthcare Syst, Gastroenterol Sect, Boston, MA 02130 USA.
C3 Harvard University; Harvard University Medical Affiliates; US Department
   of Veterans Affairs; Veterans Health Administration (VHA); VA Boston
   Healthcare System; Harvard University; Harvard University Medical
   Affiliates; Brigham & Women's Hospital; Harvard Medical School; Harvard
   University; Harvard University Medical Affiliates; US Department of
   Veterans Affairs; Veterans Health Administration (VHA); VA Boston
   Healthcare System
RP Baffy, G (corresponding author), VA Boston Healthcare Syst, Gastroenterol Sect, 150 S Huntington Ave,Room 6A-46, Boston, MA 02130 USA.
EM gbaffy@partners.org
RI Baffy, Gyorgy/P-7986-2018
OI Baffy, Gyorgy/0000-0002-8334-0400
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NR 50
TC 4
Z9 4
U1 0
U2 9
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0163-2116
EI 1573-2568
J9 DIGEST DIS SCI
JI Dig. Dis. Sci.
PD FEB
PY 2013
VL 58
IS 2
BP 302
EP 308
DI 10.1007/s10620-012-2344-8
PG 7
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 094UZ
UT WOS:000315291100006
PM 22886595
DA 2025-06-11
ER

PT J
AU Zabihi, NA
   Pirro, M
   Johnston, TP
   Sahebkar, A
AF Zabihi, Narges Amel
   Pirro, Matteo
   Johnston, Thomas P.
   Sahebkar, Amirhossein
TI Is There a Role for Curcumin Supplementation in the Treatment of
   Non-Alcoholic Fatty Liver Disease? The Data Suggest Yes
SO CURRENT PHARMACEUTICAL DESIGN
LA English
DT Review
DE Curcumin; steatosis; non-alcoholic steatohepatitis; dyslipidemia;
   inflammation
ID HEPATIC STELLATE CELLS; RANDOMIZED CONTROLLED-TRIAL; INDUCED
   LIPID-ACCUMULATION; LOW-DENSITY-LIPOPROTEIN; BINDING PROTEIN-LEVELS;
   NF-KAPPA-B; INSULIN-RESISTANCE; OXIDATIVE STRESS; GENE-EXPRESSION;
   LDL-RECEPTOR
AB Nonalcoholic fatty liver disease (NAFLD) is the most common type of liver disease. NAFLD is considered a multifactorial disease and a clinically relevant hepatic manifestation of metabolic syndrome. NAFLD is often accompanied by a constellation of metabolic and non-metabolic alterations, like dyslipidemia, insulin resistance in the liver and peripheral tissues, inflammation and oxidative stress; therefore, treatment of NAFLD should be directed at correcting all of these disturbances. The natural polyphenol curcumin has been the subject of increasing research for the treatment of NAFLD due to its lipid-modifying, antioxidant, anti-inflammatory, insulin-sensitizing, anti-steatotic, and anti-fibrotic properties. The therapeutic efficacy of curcumin has been demonstrated in several experimental models of NAFLD, however, clinical evidence is still scarce. The present review summarizes the current knowledge on the impact of curcumin supplementation on different biochemical and histopathological features of NAFLD.
C1 [Zabihi, Narges Amel] Mashhad Univ Med Sci, Sch Pharm, Neurogen Inflammat Res Ctr, Mashhad, Iran.
   [Pirro, Matteo] Univ Perugia, Dept Med, Unit Internal Med, Angiol & Arteriosclerosis Dis, Perugia, Italy.
   [Johnston, Thomas P.] Univ Missouri, Sch Pharm, Div Pharmaceut Sci, Kansas City, MO 64110 USA.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Biotechnol Res Ctr, Mashhad, Iran.
   [Sahebkar, Amirhossein] Univ Western Australia, Royal Perth Hosp, Sch Med & Pharmacol, Metab Res Ctr, Perth, WA, Australia.
C3 Mashhad University of Medical Sciences; University of Perugia;
   University of Missouri System; University of Missouri Kansas City;
   Mashhad University of Medical Sciences; University of Western Australia;
   East Metropolitan Health Service; Royal Perth Hospital
RP Sahebkar, A (corresponding author), Mashhad Univ Med Sci, Sch Med, Dept Med Biotechnol, POB 91779-48564, Mashhad, Iran.
EM sahebkara@mums.ac.ir
RI Sahebkar, Amirhossein/B-5124-2018; Pirro, Matteo/AAC-2318-2022
OI Pirro, Matteo/0000-0002-5527-4821
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NR 199
TC 68
Z9 69
U1 6
U2 38
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1381-6128
EI 1873-4286
J9 CURR PHARM DESIGN
JI Curr. Pharm. Design
PY 2017
VL 23
IS 7
BP 969
EP 982
DI 10.2174/1381612822666161010115235
PG 14
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA ET7XL
UT WOS:000400512700002
PM 27748192
DA 2025-06-11
ER

PT J
AU Rodrigo, S
   Panadero, MI
   Fauste, E
   Rodríguez, L
   Roglans, N
   Alvarez-Millán, JJ
   Otero, P
   Laguna, JC
   Bocos, C
AF Rodrigo, Silvia
   Panadero, Maria, I
   Fauste, Elena
   Rodriguez, Lourdes
   Roglans, Nuria
   Alvarez-Millan, Juan J.
   Otero, Paola
   Laguna, Juan C.
   Bocos, Carlos
TI Effects of Maternal Fructose Intake on Perinatal ER-Stress: A Defective
   XBP1s Nuclear Translocation Affects the ER-stress Resolution
SO NUTRIENTS
LA English
DT Article
DE fructose; pregnancy; ER stress; methylglyoxal; XBP1s
ID ENDOPLASMIC-RETICULUM STRESS; UNFOLDED PROTEIN RESPONSE;
   GLUCOSE-HOMEOSTASIS; REGULATORY SUBUNITS; OXIDATIVE STRESS;
   ADIPOSE-TISSUE; MESSENGER-RNA; CORN SYRUP; CONSUMPTION; ACTIVATION
AB Endoplasmic reticulum (ER) homeostasis is crucial to appropriate cell functioning, and when disturbed, a safeguard system called unfolded protein response (UPR) is activated. Fructose consumption modifies ER homeostasis and has been related to metabolic syndrome. However, fructose sweetened beverages intake is allowed during gestation. Therefore, we investigate whether maternal fructose intake affects the ER status and induces UPR. Thus, administrating liquid fructose (10% w/v) to pregnant rats partially activated the ER-stress in maternal and fetal liver and placenta. In fact, a fructose-induced increase in the levels of pIRE1 (phosphorylated inositol requiring enzyme-1) and its downstream effector, X-box binding protein-1 spliced form (XBP1s), was observed. XBP1s is a key transcription factor, however, XBP1s nuclear translocation and the expression of its target genes were reduced in the liver of the carbohydrate-fed mothers, and specifically diminished in the fetal liver and placenta in the fructose-fed mothers. These XBP1s target genes belong to the ER-associated protein degradation (ERAD) system, used to buffer ER-stress and to restore ER-homeostasis. It is known that XBP1s needs to form a complex with diverse proteins to migrate into the nucleus. Since methylglyoxal (MGO) content, a precursor of advanced glycation endproducts (AGE), was augmented in the three tissues in the fructose-fed mothers and has been related to interfere with the functioning of many proteins, the role of MGO in XBP1s migration should not be discarded. In conclusion, maternal fructose intake produces ER-stress, but without XBP1s nuclear migration. Therefore, a complete activation of UPR that would resolve ER-stress is lacking. A state of fructose-induced oxidative stress is probably involved.
C1 [Rodrigo, Silvia; Panadero, Maria, I; Fauste, Elena; Rodriguez, Lourdes; Otero, Paola; Bocos, Carlos] Univ San Pablo CEU, Fac Farm, CEU Univ, Madrid 28668, Spain.
   [Roglans, Nuria; Laguna, Juan C.] Univ Barcelona, Fac Farm, CIBERobn, IBUB, Avda Joan 23 27-31, E-08028 Barcelona, Spain.
   [Alvarez-Millan, Juan J.] CQS Lab, Calle Marie Curie 5, Madrid 28521, Spain.
C3 San Pablo CEU University; University of Barcelona; CIBER - Centro de
   Investigacion Biomedica en Red; CIBEROBN
RP Bocos, C (corresponding author), Univ San Pablo CEU, Fac Farm, CEU Univ, Madrid 28668, Spain.
EM carbocos@ceu.es
RI Laguna, JCLaguna/C-5481-2017; Roglans, Núria/ABH-1242-2020; Fauste,
   Elena/AAT-8282-2020; Panadero, Maria I./L-4262-2017; BOCOS,
   CARLOS/B-8460-2015
OI Roglans, Nuria/0000-0002-5018-021X; Panadero, Maria
   I./0000-0003-0459-3539; Alvarez Millan, Juan Jose/0000-0002-6774-4958;
   Fauste, Elena/0000-0002-5783-3092; BOCOS, CARLOS/0000-0003-0364-5958
FU Ministerio de Ciencia, Innovacion y Universidades (MICINN)
   [SAF2017-89537-R, SAF2017-82369-R]; Universidad San Pablo-CEU
   [PC09/2018]; European Community FEDER funds; FUSP-CEU fellowship; FPU
   fellowship from MICINN
FX This work was supported by the grants from the Ministerio de Ciencia,
   Innovacion y Universidades (MICINN) (SAF2017-89537-R and
   SAF2017-82369-R), Universidad San Pablo-CEU (PC09/2018), and European
   Community FEDER funds. Silvia Rodrigo was supported with a FUSP-CEU
   fellowship. Elena Fauste is supported with an FPU fellowship from
   MICINN.
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NR 54
TC 5
Z9 5
U1 0
U2 3
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD AUG
PY 2019
VL 11
IS 8
AR 1935
DI 10.3390/nu11081935
PG 16
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA IV8HH
UT WOS:000484506000217
PM 31426466
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU dos Santos, PP
   Fujimori, ASS
   Polegato, BF
   Okoshi, MP
AF dos Santos, Priscila Portugal
   Fujimori, Anderson Seiji Soares
   Polegato, Bertha Furlan
   Okoshi, Marina Politi
TI The Therapeutic Potential of Orange Juice in Cardiac Remodeling: A
   Metabolomics Approach
SO METABOLITES
LA English
DT Article
DE orange juice; energy metabolism; gut microbiota; cardiac remodeling;
   cardiovascular diseases
ID CYCLIC PHOSPHATIDIC-ACID; CHAIN FATTY-ACIDS; RISK-FACTORS; METABOLISM;
   PHOSPHATIDYLETHANOLAMINE; ACTIVATION; SYSTEM; SECRETION; URINARY; PPARS
AB Cardiovascular diseases are a leading cause of death worldwide, and the process of cardiac remodeling lies at the core of most of these diseases. Sustained cardiac remodeling almost unavoidably ends in progressive muscle dysfunction, heart failure, and ultimately death. Therefore, in order to attenuate cardiac remodeling and reduce mortality, different therapies have been used, but it is important to identify adjuvant factors that can help to modulate this process. One of these factors is the inclusion of affordable foods in the diet with potential cardioprotective properties. Orange juice intake has been associated with several beneficial metabolic changes, which may influence cardiac remodeling induced by cardiovascular diseases. Current opinion highlights how the metabolites and metabolic pathways modulated by orange juice consumption could potentially attenuate cardiac remodeling. It was observed that orange juice intake significantly modulates phospholipids, energy metabolism, endocannabinoid signaling, amino acids, and gut microbiota diversity, improving insulin resistance, dyslipidemia, and metabolic syndrome. Specifically, modulation of phosphatidylethanolamine (PE) metabolism and activation of PPAR alpha and PPAR gamma receptors, associated with improved energy metabolism, mitochondrial function, and oxidative stress, showed protective effects on the heart. Furthermore, orange juice intake positively impacted gut microbiota diversity and led to an increase in beneficial bacterial populations, correlated with improved metabolic syndrome. These findings suggest that orange juice may act as a metabolic modulator, with potential therapeutic implications for cardiac remodeling associated with cardiovascular diseases.
C1 [dos Santos, Priscila Portugal; Fujimori, Anderson Seiji Soares; Polegato, Bertha Furlan; Okoshi, Marina Politi] Sao Paulo State Univ UNESP, Botucatu Med Sch, Internal Med Dept, BR-18618687 Botucatu, Brazil.
C3 Universidade Estadual Paulista
RP dos Santos, PP (corresponding author), Sao Paulo State Univ UNESP, Botucatu Med Sch, Internal Med Dept, BR-18618687 Botucatu, Brazil.
EM priscila.portugal@unesp.br; seiji.fujimori@unesp.br;
   bertha.polegato@unesp.br; marina.okoshi@unesp.br
RI Okoshi, Marina/F-4809-2010; Santos, Priscila/U-5345-2018; Polegato,
   Bertha/E-8842-2012
OI Polegato, Bertha/0000-0002-2875-9532
FU Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
   [307.703/2022-3]
FX This research was funded by Conselho Nacional de Desenvolvimento
   Cientifico e Tecnologico (CNPq) process number: 307.703/2022-3.
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NR 99
TC 0
Z9 0
U1 0
U2 0
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2218-1989
J9 METABOLITES
JI Metabolites
PD MAR 13
PY 2025
VL 15
IS 3
AR 198
DI 10.3390/metabo15030198
PG 16
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 0PF4U
UT WOS:001452737300001
PM 40137162
OA gold
DA 2025-06-11
ER

PT J
AU Binetti, J
   Bertran, L
   Riesco, D
   Aguilar, C
   Martínez, S
   Sabench, F
   Porras, JA
   Camaron, J
   Del Castillo, D
   Richart, C
   Auguet, T
AF Binetti, Jessica
   Bertran, Laia
   Riesco, David
   Aguilar, Carmen
   Martinez, Salome
   Sabench, Fatima
   Antonio Porras, Jose
   Camaron, Javier
   Del Castillo, Daniel
   Richart, Cristobal
   Auguet, Teresa
TI Deregulated Serotonin Pathway in Women with Morbid Obesity and NAFLD
SO LIFE-BASEL
LA English
DT Article
DE serotonin; non-alcoholic fatty liver disease; morbid obesity; bariatric
   surgery; metabolic syndrome
ID FATTY LIVER-DISEASE; PERIPHERAL SEROTONIN; OXIDATIVE STRESS; PLASMA
   SEROTONIN; METABOLIC ROLES; 5-HT4 RECEPTORS; GUT MICROBIOTA;
   CELL-FUNCTION; WEIGHT-LOSS; EXPRESSION
AB Non-alcoholic fatty liver disease (NAFLD) extends from simple steatosis (SS) to non-alcoholic steatohepatitis (NASH). Peripheral serotonin (5-HT) has become as an important regulator of different metabolic pathways. 5-HT has been related to obesity and lipid accumulation in the liver. The objective of this study was to assess the relationship between the 5-HT signaling pathway and the degree of NAFLD, as well as to investigate whether peripheral 5-HT levels are related to the hepatic and jejunal mRNA abundance of serotonin receptors (HTR) in a cohort of women with morbid obesity (MO) and NAFLD. ELISA was used to quantify the serum 5-HT from normal-weight subjects (n = 26) and patients with MO (n = 58). We used RTq-PCR analysis to evaluate the relative expression of HTR in women with MO with normal liver (n = 22), SS (n = 21), and NASH (n = 15). The 5-HT was diminished in women with MO under a hypocaloric diet, regardless of the presence of NAFLD. Additionally, we report a negative correlation of 5-HT levels with metabolic syndrome criteria, suggesting that serotonin may have a protective role in obesity. Additionally, the hepatic expression of HTR2A and HTR2B were decreased in women with MO and NAFLD, but no significant differences in the HTR jejunal expression according to the presence of NAFLD were found.
C1 [Binetti, Jessica; Bertran, Laia; Aguilar, Carmen; Antonio Porras, Jose; Richart, Cristobal; Auguet, Teresa] Univ Rovira & Virgili URV, Inst Invest Sanitaria Pere Virgili IISPV, Dept Med & Cirurgia, Grp Recerca GEMMAIR AGAUR Med Aplicada, Tarragona 43007, Spain.
   [Binetti, Jessica; Riesco, David; Antonio Porras, Jose; Camaron, Javier; Richart, Cristobal; Auguet, Teresa] Hosp Univ Tarragona Joan XXIII, Serv Med Interna, Tarragona 43007, Spain.
   [Martinez, Salome] Hosp Univ Tarragona Joan XXIII, Serv Anat Patol, Tarragona 43007, Spain.
   [Sabench, Fatima; Del Castillo, Daniel] Univ Rovira & Virgili URV, Inst Invest Sanitaria Pere Virgili IISPV, Dept Med & Cirurgia, Serv Cirurgia,Hosp Univ St Joan de Reus, Reus 43204, Spain.
C3 Universitat Rovira i Virgili; Institut d'Investigacio Sanitaria Pere
   Virgili (IISPV); Universitat Rovira i Virgili; Hospital Universitari De
   Tarragona Joan XXIII; Universitat Rovira i Virgili; Hospital
   Universitari De Tarragona Joan XXIII; Universitat Rovira i Virgili;
   Institut d'Investigacio Sanitaria Pere Virgili (IISPV)
RP Auguet, T (corresponding author), Univ Rovira & Virgili URV, Inst Invest Sanitaria Pere Virgili IISPV, Dept Med & Cirurgia, Grp Recerca GEMMAIR AGAUR Med Aplicada, Tarragona 43007, Spain.; Auguet, T (corresponding author), Hosp Univ Tarragona Joan XXIII, Serv Med Interna, Tarragona 43007, Spain.
EM jessica.binetti@gmail.com; laia.bertran@urv.cat;
   driesco.hj23.ics@gencat.cat; caguilar.hj23.ics@gencat.cat;
   mgonzalez.hj23.ics@gencat.cat; fatima.sabench@urv.cat;
   aporras.hj23.ics@gencat.cat; javiercamaron93@gmail.com;
   danieldel.castillo@urv.cat; cristobalmanuel.richart@urv.cat;
   tauguet.hj23.ics@gencat.cat
RI budesca, pilar/HSG-1381-2023; Bertran, Laia/AAD-4127-2020; Binetti,
   Jessica/AAC-5815-2020; Auguet, Teresa/AAC-5838-2020; Salome,
   Martinez/AAD-1860-2020; Porras, José/ABU-0274-2022; Crespillo Carmen,
   Aguilar/AAC-6209-2020; Sabench, Fatima/HSG-1966-2023; RICHART,
   CRISTOBAL/S-9158-2017; AGUILAR CRESPILLO, CARMEN ISABEL/ADI-7042-2022
OI MARTINEZ, SALOME/0000-0001-6185-2889; Auguet,
   Teresa/0000-0003-0396-6428; Bertran Ramos, Laia/0000-0001-9052-1368;
   Sabench, Fatima/0000-0002-9262-8756; RICHART,
   CRISTOBAL/0000-0003-0852-6739; AGUILAR CRESPILLO, CARMEN
   ISABEL/0000-0002-4440-562X; Binetti, Jessica A./0000-0001-9660-7752;
   Porras Ledantes, Jose Antonio/0000-0001-6418-1822
FU Instituto de Salud Carlos III [PI16/00498]; European Regional
   Development Fund "A way to make Europe"; Agencia de Gestio d'Ajuts
   Universitaris de Recerca [AGAUR 2017 SGR 357]; Grup de Recerca en
   Medicina Aplicada URV [2016PFR-URV-B2-72]; Grup estudi Malalties
   metaboliques associades a insulin resistencia [2019PFR-URV-71]; City
   Council of Perafort
FX This study has been funded by Instituto de Salud Carlos III through the
   project PI16/00498 (to Teresa Auguet) (Co-funded by European Regional
   Development Fund "A way to make Europe"), by funds from Agencia de
   Gestio d'Ajuts Universitaris de Recerca (AGAUR 2017 SGR 357 to Cristobal
   Richart) and the Grup de Recerca en Medicina Aplicada URV
   (2016PFR-URV-B2-72 to Cristobal Richart), Grup estudi Malalties
   metaboliques associades a insulin resistencia (2019PFR-URV-71) and a
   donation from the City Council of Perafort.
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NR 67
TC 11
Z9 12
U1 0
U2 13
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2075-1729
J9 LIFE-BASEL
JI Life-Basel
PD OCT
PY 2020
VL 10
IS 10
AR 245
DI 10.3390/life10100245
PG 17
WC Biology; Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics; Microbiology
GA OM9AW
UT WOS:000586308900001
PM 33081272
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Gasparova, Z
   Ruskova, E
   Michalikova, DS
   Brnoliakova, Z
   Svik, K
   Slovak, L
   Bezek, S
   Knezl, V
   Sotnikova, R
AF Gasparova, Zdenka
   Ruskova, Euridika
   Michalikova, Dominika Seckarova
   Brnoliakova, Zuzana
   Svik, Karol
   Slovak, Lukas
   Bezek, Stefan
   Knezl, Vladimir
   Sotnikova, Ruzena
TI High-fructose intake-induced dyslipidemia and oxidative stress
   accompanied by hippocampal dysfunctions in hypertensive but not
   hypertriacylglycerolemic rats
SO GENERAL PHYSIOLOGY AND BIOPHYSICS
LA English
DT Article
DE Fructose; Oxidative stress; Lipid profile; Hypertension; Synaptic
   plasticity
ID INSULIN SENSITIVITY; SYNAPTIC PLASTICITY; DIETARY FRUCTOSE;
   LIPID-METABOLISM; RISK-FACTOR; CONSUMPTION; GLUCOSE; RESISTANCE;
   BEVERAGES; GENES
AB A high-fructose intake is metabolically analogous to a high-fat diet. The impact of highfructose intake was investigated in spontaneously hypertensive (SHR) and hypertriacylglycerolemic (HTG) rats to find out the impact of which risk factor of metabolic syndrome - hypertension or hypertriacylglycerolemia - will cause more complications. Rats were fed a standard or a fructose diet (F60) with 60% of added fructose for 5 weeks. The F60 diet increased the total serum cholesterol content of both HTG-F60 and SHR-F60 rats. Further, in SHR-F60 it increased serum triacylglycerols, TBARS in the liver, a specific activity of NAGA in the kidney, aggravated glucose tolerance, deteriorated synaptic plasticity, and reduced somatic and dendritic responses in the hippocampus. SHR rats were more sensitive to the F60 diet, suggesting that hypertension along with a high-fructose intake result in a more pronounced disorder compared to hypertriacylglycerolemia. This work wants to draw attention to fructose-induced health risks associated with hypertension.
C1 [Gasparova, Zdenka; Ruskova, Euridika; Michalikova, Dominika Seckarova; Brnoliakova, Zuzana; Svik, Karol; Slovak, Lukas; Bezek, Stefan; Knezl, Vladimir; Sotnikova, Ruzena] Slovak Acad Sci, Inst Expt Pharmacol & Toxicol, Ctr Expt Med, Bratislava, Slovakia.
C3 Slovak Academy of Sciences; Centre of Experimental Medicine, SAS;
   Institute of Experimental Pharmacology & Toxicology, SAS
RP Gasparova, Z (corresponding author), Slovak Acad Sci, Inst Expt Pharmacol & Toxicol, Ctr Expt Med, Bratislava, Slovakia.
EM exfagasp@savba.sk
OI Gasparova, Zdenka/0000-0002-5163-7402
FU VEGA [2/0120/19, 2/0104/21, 2/0018/23, APVV-18-0336]; EU [ITMS
   2014+313021Y920]
FX Acknowledgment. This work was supported by grants of VEGA No. 2/0120/19;
   VEGANo. 2/0104/21; VEGANo. 2/0018/23; APVV-18-0336, and EU project ITMS
   2014+313021Y920. The authors thank Mrs. Julia Polakova, Mrs. Monika
   Srnova, and Mrs. Katarina Vandakova for their technical assistance.
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NR 68
TC 1
Z9 1
U1 1
U2 10
PU AEPRESS SRO
PI BRATISLAVA
PA BAJZOVA 7, BRATISLAVA, 821 08, SLOVAKIA
SN 0231-5882
EI 1338-4325
J9 GEN PHYSIOL BIOPHYS
JI Gen. Physiol. Biophys.
PY 2023
VL 42
IS 1
BP 25
EP 36
DI 10.4149/gpb_2022053
PG 12
WC Biochemistry & Molecular Biology; Biophysics; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Physiology
GA J8NZ4
UT WOS:001012150000003
PM 36705302
OA gold
DA 2025-06-11
ER

PT J
AU Goyache, I
   Valdés-Varela, L
   Virto, R
   López-Yoldi, M
   López-Giral, N
   Sánchez-Vicente, A
   Milagro, FI
   Aranaz, P
AF Goyache, Ignacio
   Valdes-Varela, Lorena
   Virto, Raquel
   Lopez-Yoldi, Miguel
   Lopez-Giral, Noelia
   Sanchez-Vicente, Ana
   Milagro, Fermin I.
   Aranaz, Paula
TI Anti-Obesity Properties of a Novel Probiotic Strain of
   Latilactobacillus sakei CNTA 173 in Caenorhabditis elegans
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE obesity; probiotics; Caenorhabditis elegans
ID LACTIC-ACID BACTERIA; ESCHERICHIA-COLI O157-H7; CACO-2 CELLS; IN-VITRO;
   BIFIDOBACTERIUM STRAINS; FAT ACCUMULATION; C. ELEGANS; ADHESION;
   INHIBITION; PATHOGENS
AB Probiotic strains with health-promoting activities have emerged as a promising strategy to prevent or treat different metabolic syndrome-related disturbances, including obesity or type 2 diabetes. In this work, we characterize the probiotic properties of a novel strain of Latilactobacillus sakei (L. sakei) CNTA 173, and we demonstrate its anti-obesity properties using the in vivo model Caenorhabditis elegans (C. elegans). This new strain exhibited sensitivity to the entire spectrum of antibiotics analysed, gastric and intestinal in vitro resistance, beta-galactosidase activity, and the ability to form biofilm and to produce acetic acid in vitro. Cell culture analyses demonstrated that L. sakei CNTA 173 was able to reduce the adhesion to Caco-2 cells of the pathogenic E. coli O157:H7 and to exert immunomodulatory capacity in RAW 264.7 and HT-29 in vitro models. Furthermore, supplementation with L. sakei CNTA 173 counteracted the deleterious effects of glucose in C. elegans by significantly reducing fat accumulation, enhancing the oxidative stress response, and extending lifespan by directly regulating the carbohydrate and lipid metabolism-related genes acox-1, maoc-1, and daf-16. Our results unveil new strain-specific mechanisms of action by which L. sakei CNTA 173 exerts beneficial effects in vitro and in C. elegans, and suggest potential application of this novel probiotic strain in the prevention and treatment of metabolic syndrome-related disturbances.
C1 [Goyache, Ignacio; Milagro, Fermin I.] Univ Navarra, Fac Pharm & Nutr, Dept Nutr Food Sci & Physiol, Pamplona 31008, Spain.
   [Goyache, Ignacio; Lopez-Yoldi, Miguel; Milagro, Fermin I.; Aranaz, Paula] Univ Navarra, Ctr Nutr Res, C-Irunlarrea 1, Pamplona 31008, Spain.
   [Valdes-Varela, Lorena; Virto, Raquel; Lopez-Giral, Noelia; Sanchez-Vicente, Ana] Ctr Nacl Tecnol & Seguridad Alimentaria CNTA, Ctra NA-134,Km 53, San Adrian 31570, Spain.
   [Milagro, Fermin I.; Aranaz, Paula] Navarra Inst Hlth Res IdiSNA, Pamplona 31008, Spain.
   [Milagro, Fermin I.] Inst Salud Carlos III, Ctr Invest Biomed Red Fisiopatol Obes & Nutr CIBER, Madrid 28029, Spain.
C3 University of Navarra; University of Navarra; University of Navarra;
   Instituto de Salud Carlos III
RP Aranaz, P (corresponding author), Univ Navarra, Ctr Nutr Res, C-Irunlarrea 1, Pamplona 31008, Spain.; Aranaz, P (corresponding author), Navarra Inst Hlth Res IdiSNA, Pamplona 31008, Spain.
EM igoyache@unav.es; lvaldes@cnta.es; rvirto@cnta.es; mlyoldi@unav.es;
   noelia22269@gmail.com; asanchez@cnta.es; fmilagro@unav.es;
   paranaz@unav.es
RI Milagro, Fermin/F-2315-2015
FU Gobierno de Navarra;  [0011-1383-2022-000000 [PC128-129 PARABIOTICS]]; 
   [0011-1383-2020-000010 [PC173-174 PREDISMET]];  [0011-1383-2024-000000
   [PC24-PARABIOTICS-2-007-006]]
FX This research was funded by Gobierno de Navarra: 0011-1383-2022-000000
   [PC128-129 PARABIOTICS], 0011-1383-2020-000010 [PC173-174 PREDISMET],
   0011-1383-2024-000000 [PC24-PARABIOTICS-2-007-006]).
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NR 61
TC 0
Z9 0
U1 3
U2 3
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD APR 1
PY 2025
VL 26
IS 7
AR 3286
DI 10.3390/ijms26073286
PG 23
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 1FQ8F
UT WOS:001463902100001
PM 40244138
DA 2025-06-11
ER

PT J
AU da Silva, GR
   Kluck, AJ
   Albuquerque, ER
   Guarnier, LP
   Braga, FD
   Silva, EP
   Negrini, KS
   Mendonça, JA
   Gazim, ZC
   Gasparotto, A Jr
   Ribeiro-Paes, JT
   Lívero, FAD
AF da Silva, Gustavo Ratti
   Kluck, Arianne Jung
   Albuquerque, Edilson Rodrigues
   Guarnier, Lucas Pires
   Braga, Fernanda de Abreu
   Silva, Ester Pelegrini
   Negrini, Karina Sposito
   Mendonca, Juliana Aparecida
   Gazim, Zilda Cristiani
   Gasparotto Junior, Arquimedes
   Ribeiro-Paes, Joao Tadeu
   Livero, Francislaine Aparecida dos Reis
TI Effects of Baccharis dracunculifolia DC on an Innovative Animal
   Model of Cardiometabolic Syndrome
SO PHARMACEUTICS
LA English
DT Article
DE alecrim-do-campo; diabetes; dyslipidemia; metabolic syndrome;
   preclinical study; smoking; traditional medicine
ID FATTY LIVER-DISEASE; ANTIOXIDANT ACTIVITY; IN-VITRO; HYDROETHANOLIC
   EXTRACT; METABOLIC SYNDROME; PHENOLIC-ACIDS; TRIMERA; INFLAMMATION;
   FLAVONOIDS; ETHANOL
AB Background/Objective: Cardiometabolic syndrome (CMS) is a complex clinical condition that encompasses metabolic dysregulation, cardiovascular disease, and diabetes risk factors. Worldwide, CMS is underdiagnosed, and its occurrence significantly increases cardiovascular morbimortality. Despite available pharmacological treatments, the approach is fragmented, and the associated clinical conditions are treated independently. This approach may be partially due to limited preclinical models to mimic the clinical conditions of CMS. Therefore, our study aims to present an innovative animal model of cardiometabolic syndrome and evaluate the effects of Baccharis dracunculifolia on the set of clinical alterations associated with the condition. Methods: Female Wistar rats were induced to develop diabetes, fed a cholesterol-enriched diet, and exposed to the smoke of 9 cigarettes/day for 6 weeks. During the last 2 weeks, the rats were treated with vehicle, B. dracunculifolia (30, 100, and 300 mg/kg), or a combination of simvastatin and insulin. At the end of the treatment, plasma lipid levels were measured, and the liver was analyzed histologically for hepatic lipid quantification and oxidative stress assessment. Results: Phytochemical analysis revealed seven phenolic acids and six flavonoids in the extract. B. dracunculifolia showed significant hepatoprotective effects, reducing AST and ALT levels and lowering both plasma and hepatic lipid levels. The extract also reversed hepatic steatosis and demonstrated antioxidant properties. Conclusions: These findings suggest that B. dracunculifolia may be a therapeutic option for the metabolic dysregulation present in CMS.
C1 [da Silva, Gustavo Ratti; Albuquerque, Edilson Rodrigues] Univ Paranaense, Postgrad Program Anim Sci Emphasis Bioact Prod, Lab Preclin Res Nat Prod, BR-81531980 Umuarama, Brazil.
   [Kluck, Arianne Jung; Livero, Francislaine Aparecida dos Reis] Fed Univ Parana UFPR, Lab Cardiometab Pharmacol, BR-81531990 Curitiba, Brazil.
   [Guarnier, Lucas Pires] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Genet, BR-14049900 Ribeirao Preto, Brazil.
   [Braga, Fernanda de Abreu; Silva, Ester Pelegrini; Negrini, Karina Sposito; Livero, Francislaine Aparecida dos Reis] Univ Paranaense, Postgrad Program Med Plants & Phytotherapeut Basic, Lab Preclin Res Nat Prod, BR-81531980 Umuarama, Brazil.
   [Mendonca, Juliana Aparecida] Univ Paranaense, Postgrad Program Biotechnol Appl Agr, Chem Lab Nat Prod, BR-81531980 Umuarama, Brazil.
   [Gazim, Zilda Cristiani] Univ Paranaense, Postgrad Programs Anim Sci & Biotechnol Appl Agr, Chem Lab Nat Prod, BR-81531980 Umuarama, Brazil.
   [Gasparotto Junior, Arquimedes] Fed Univ Grande Dourados, Fac Hlth Sci, Lab Cardiovasc Pharmacol, BR-79804970 Dourados, Brazil.
   [Ribeiro-Paes, Joao Tadeu] Sao Paulo State Univ, Dept Biotechnol, Lab Genet & Cell Therapy GenTe Cel, BR-19806900 Assis, Brazil.
C3 Universidade Paranaense; Universidade de Sao Paulo; Universidade
   Paranaense; Universidade Paranaense; Universidade Paranaense;
   Universidade Federal da Grande Dourados; Universidade Estadual Paulista
RP Lívero, FAD (corresponding author), Fed Univ Parana UFPR, Lab Cardiometab Pharmacol, BR-81531990 Curitiba, Brazil.; Lívero, FAD (corresponding author), Univ Paranaense, Postgrad Program Med Plants & Phytotherapeut Basic, Lab Preclin Res Nat Prod, BR-81531980 Umuarama, Brazil.
EM gustavoratti@gmail.com; ariannejung1@gmail.com;
   albuquerque.ed@gmail.com; lucasguarnier@usp.br; f.braga@edu.unipar.br;
   ester.s@edu.unipar.br; karina.negrini@edu.unipar.br;
   juliana.mendonca@edu.unipar.br; cristianigazim@prof.unipar.br;
   arquimedesgasparotto@gmail.com; ribeiro.paes@unesp.br;
   francislaine@ufpr.br
RI Lívero, Francislaine/AAG-6083-2019; Ribeiro-Paes, João/AAB-8937-2021;
   Gazim, Zilda/ADF-1787-2022; Gasparotto Junior, Arquimedes/Q-3281-2016;
   Guarnier, Lucas Pires/GNP-5772-2022
OI Jung Kluck, Arianne/0009-0004-2274-4200; Gazim, Zilda
   Cristiani/0000-0003-0392-5976; Gasparotto Junior,
   Arquimedes/0000-0003-3433-5098; Guarnier, Lucas
   Pires/0000-0002-0733-1975; Rodrigues Albuquerque,
   Edilson/0000-0001-5773-9912; Aparecida Mendonca,
   Juliana/0000-0002-5818-4186
FU Coordenadoria de Pos-Graduacao (COPG, UNIPAR, Brazil); Conselho Nacional
   de Desenvolvimento Cientifico e Tecnologico (CNPq, Brazil)
   [150258/2023-2, 310105/2021-8]
FX This research was funded by Coordenadoria de Pos-Graduacao (COPG,
   UNIPAR, Brazil) and Conselho Nacional de Desenvolvimento Cientifico e
   Tecnologico (CNPq, Brazil, 150258/2023-2 and 310105/2021-8)
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NR 70
TC 1
Z9 1
U1 1
U2 1
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1999-4923
J9 PHARMACEUTICS
JI Pharmaceutics
PD NOV
PY 2024
VL 16
IS 11
AR 1446
DI 10.3390/pharmaceutics16111446
PG 16
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA N7B5H
UT WOS:001365847700001
PM 39598569
OA gold
DA 2025-06-11
ER

PT J
AU Ayala, L
   Sánchez, CJ
   Hernández, F
   Madrid, J
   López, MJ
   Martínez-Miró, S
AF Ayala, Lucia
   Sanchez, Cristian Jesus
   Hernandez, Fuensanta
   Madrid, Josefa
   Lopez, Miguel Jose
   Martinez-Miro, Silvia
TI A Comparison of Haematological and Biochemical Profiles between
   Intrauterine Growth Restriction and Normal Piglets at 72 Hours
   Postpartum
SO ANIMALS
LA English
DT Article
DE IUGR; piglets; haematology; biochemical profile
ID MEAN PLATELET VOLUME; AGE-RELATED-CHANGES; METABOLIC SYNDROME; COLOSTRUM
   INTAKE; IRON-DEFICIENCY; HEAD SHAPE; SURVIVAL; WEIGHT; MODELS; PERIOD
AB Intrauterine growth restriction in piglets has been a problem in the pig industry due to genetic selection based on hyperprolificacy. This has led to an increase in the number of underweight piglets and a worsening of the survival rate. The goal of this study was to enhance the knowledge of differences between normal and IUGR piglets a few hours after birth in terms of haematological variables, biochemical parameters, and immunoglobulin levels. Two groups of 20 piglets each were assessed. The control group (N) was made up of piglets with weights greater than 1500 g, and the IUGR group consisted of piglets weighing 500-1000 g and with at least two IUGR features. Blood samples were collected 72 h after birth for analysis of the red and white blood cell parameters, reticulocyte indices, platelet indices, biochemical parameters, and immunoglobulin levels. Alterations in red blood cells and reticulocytes, a lower lymphocyte count, hyperinsulinemia, and high oxidative stress were observed in IUGR piglets (p < 0.05). In contrast, differences were not observed (p > 0.05) in the serum immunoglobulin level. It can be concluded that the haematological and biochemical differences in IUGR piglets with respect to normal-weight piglets are present at birth indicating possible alterations in immunity, metabolism, and redox status; therefore, IUGR piglets could be more vulnerable to illness and future disorders, such as metabolic syndrome.
C1 [Ayala, Lucia; Sanchez, Cristian Jesus; Hernandez, Fuensanta; Madrid, Josefa; Lopez, Miguel Jose; Martinez-Miro, Silvia] Univ Murcia, Fac Vet, Dept Anim Prod, Int Excellence Campus Higher Educ & Res Campus Mar, Murcia 30100, Spain.
C3 University of Murcia
RP Martínez-Miró, S (corresponding author), Univ Murcia, Fac Vet, Dept Anim Prod, Int Excellence Campus Higher Educ & Res Campus Mar, Murcia 30100, Spain.
EM lucia.ayalag@um.es; cristianjesus.sanchez@um.es; nutri@um.es;
   alimen@um.es; mjlopeza@um.es; silviamm@um.es
RI Martínez, Silvia/I-3194-2015; Hernandez Ruiperez, Fuensanta/F-3014-2016;
   Madrid, Josefa/E-7425-2016
OI Ayala Garcia, Lucia/0000-0002-3868-9961; Hernandez Ruiperez,
   Fuensanta/0000-0002-8795-416X; Sanchez Parra, Cristian
   Jesus/0000-0002-5169-321X; Madrid, Josefa/0000-0001-6255-9078
FU MCIN/AEI/ 10.13039/501100011033
FX No Statement Available
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NR 55
TC 0
Z9 0
U1 3
U2 7
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 2076-2615
J9 ANIMALS-BASEL
JI Animals
PD NOV
PY 2023
VL 13
IS 22
AR 3540
DI 10.3390/ani13223540
PG 13
WC Agriculture, Dairy & Animal Science; Veterinary Sciences; Zoology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture; Veterinary Sciences; Zoology
GA CD5X7
UT WOS:001123336200001
PM 38003158
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Kumar, SR
   Ramli, ESM
   Nasir, NAA
   Ismail, NHM
   Fahami, NAM
AF Kumar, Sivanesan Raja
   Ramli, Elvy Suhana Mohd
   Nasir, Nurul Alimah Abdul
   Ismail, Nafeeza Hj Mohd
   Fahami, Nur Azlina Mohd
TI Preventive Effect of Naringin on Metabolic Syndrome and Its Mechanism of
   Action: A Systematic Review
SO EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Review
ID OXIDATIVE STRESS; FLAVONOIDS; PROTEIN; HYPERGLYCEMIA; HYPERTENSION;
   ANTIOXIDANT; DYSFUNCTION; HESPERIDIN; PRODUCTS; MODEL
AB Background. Metabolic syndrome (MetS), which consists of cluster of conditions, hypertension, hyperlipidemia, hyperglycemia, and visceral obesity, is affecting population worldwide. Studies have shown that plant derived flavonoids have the ability to alleviate MetS. Naringin is a type of glycoside flavonoid found in most plant and it plays a critical role in the treatment of MetS due to its antioxidant activity and ability to regulate cytokines. Methods. A systematic review was done to study the effects of naringin on the metabolic diseases using electronic databases which include Ovid and Scopus using specific descriptors published from the year 2010 till present to provide updated literature on this field. The articles were assessed and chosen based on the criteria in which the mechanisms and effects of naringin on different metabolic diseases were reported. Results. Thirty-four articles were identified which referred to the studies that correspond to the previously stated criteria. Subsequently after screening for the articles that were published after the year 2010, finally, 19 articles were selected and assessed accordingly. Based on the assessment, naringin could alleviate MetS by reducing visceral obesity, blood glucose, blood pressure, and lipid profile and regulating cytokines. Conclusions. Naringin is an antioxidant that appears to be efficacious in alleviating MetS by preventing oxidative damage and proinflammatory cytokine release. However, the dosage used in animal studies might not be achieved in human trials. Thus, adequate investigation needs to be conducted to confirm naringin's effects on humans.
C1 [Kumar, Sivanesan Raja; Fahami, Nur Azlina Mohd] Univ Kebangsaan Malaysia, Fac Med, Dept Pharmacol, Batu 9 Cheras, Kuala Lumpur 56000, Malaysia.
   [Ramli, Elvy Suhana Mohd] Univ Kebangsaan Malaysia, Dept Anat, Fac Med, Batu 9 Cheras, Kuala Lumpur 56000, Malaysia.
   [Nasir, Nurul Alimah Abdul] Univ Teknol Mara, Fac Med, Dept Pharmacol, Sungai Buloh 47000, Selangor, Malaysia.
   [Ismail, Nafeeza Hj Mohd] Int Med Univ, Sch Med, Kuala Lumpur 57000, Malaysia.
C3 Universiti Kebangsaan Malaysia; Universiti Kebangsaan Malaysia;
   Universiti Teknologi MARA; International Medical University Malaysia
RP Fahami, NAM (corresponding author), Univ Kebangsaan Malaysia, Fac Med, Dept Pharmacol, Batu 9 Cheras, Kuala Lumpur 56000, Malaysia.
EM nurazlinamf@ukm.edu.my
RI Abdul Nasir, Nurul Alimah/I-7950-2019
OI Nur Azlina, Mohd Fahami/0000-0002-3458-0440; Abdul Nasir, Nurul
   Alimah/0000-0002-4285-7059
FU Universiti Kebangsaan Malaysia [FF-2017-156]; Universiti Teknologi Mara
   [600-IRMI/DANA 5/3/BESTARI (P) (013/2018)]
FX This systematic review was supported by Universiti Kebangsaan Malaysia
   [Grant number FF-2017-156] and Universiti TeknologiMara [Grant number
   600-IRMI/DANA 5/3/BESTARI (P) (013/2018).
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NR 50
TC 61
Z9 62
U1 1
U2 11
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1741-427X
EI 1741-4288
J9 EVID-BASED COMPL ALT
JI Evid.-based Complement Altern. Med.
PY 2019
VL 2019
AR 9752826
DI 10.1155/2019/9752826
PG 11
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA HL8UN
UT WOS:000459018200001
PM 30854019
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Baykal, L
   Arica, DA
   Yayli, S
   Örem, A
   Bahadir, S
   Altun, E
   Yaman, H
AF Baykal, Leyla
   Arica, Deniz Aksu
   Yayli, Savas
   Orem, Asim
   Bahadir, Sevgi
   Altun, Ece
   Yaman, Huseyin
TI Prevalence of Metabolic Syndrome in Patients with Mucosal Lichen Planus:
   A Case-Control Study
SO AMERICAN JOURNAL OF CLINICAL DERMATOLOGY
LA English
DT Article
ID CARDIOVASCULAR RISK-FACTORS; OXIDATIVE STRESS; PSORIASIS;
   ATHEROSCLEROSIS; DISEASE
AB Background Previous reports have demonstrated an association between chronic inflammation with metabolic syndrome (MS) and cardiovascular risk factors.
   Aim As lichen planus (LP) is a chronic inflammatory disease, the purpose of this study was to assess the prevalence of MS, dyslipidemia, insulin resistance and obesity in LP patients.
   Methods A total of 79 patients with LP and 79 controls were examined in this case-control study. Both groups were evaluated for the presence of MS, dyslipidemia, obesity and insulin resistance, and other cardiovascular risk factors. Erythrocyte sedimentation rate, fibrinogen and C-reactive protein were measured as inflammation markers.
   Results The prevalence of MS was significantly higher in the patients with LP than in controls (26.6 vs. 12.7 %; P = 0.045). It was also significantly higher in LP patients with mucosal involvement than without (34.5 vs. 8.3 %; P = 0.032). Among the MS criteria, mean fasting blood glucose and diastolic blood pressure were also significantly higher in LP patients than in controls (P = 0.012 and P = 0.021, respectively). No significant differences between LP patients and controls were observed with respect to prevalence of dyslipidemia and insulin resistance (P = 0.866 and P = 1.000, respectively). However, duration of disease was significantly longer in patients with insulin resistance than in those without (P = 0.034).
   Conclusions The patients with LP, particularly those with mucosal involvement, have a higher prevalence of MS, which is associated with a risk for cardiovascular diseases and diabetes mellitus.
C1 [Baykal, Leyla] Artvin State Hosp, Dept Dermatol, TR-08000 Artvin, Turkey.
   [Arica, Deniz Aksu; Yayli, Savas; Bahadir, Sevgi; Altun, Ece] Karadeniz Tech Univ, Fac Med, Dept Dermatol, Trabzon, Turkey.
   [Orem, Asim; Yaman, Huseyin] Karadeniz Tech Univ, Fac Med, Dept Biochem, Trabzon, Turkey.
C3 Artvin State Hospital; Karadeniz Technical University; Karadeniz
   Technical University
RP Baykal, L (corresponding author), Artvin State Hosp, Dept Dermatol, TR-08000 Artvin, Turkey.
EM lb_leyla@hotmail.com
RI Örem, Asım/AAK-9785-2020; Yaman, Huseyin/AAW-7002-2020; selçuk,
   leyla/A-4624-2017; arıca, deniz/AAL-5510-2021; Yayli,
   Savas/AAO-9717-2021
OI BAHADIR, Sevgi/0000-0002-1502-8933
CR Aly DG, 2010, ACTA DERMATOVEN ALP, V19, P3
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NR 28
TC 29
Z9 29
U1 0
U2 7
PU ADIS INT LTD
PI NORTHCOTE
PA 5 THE WAREHOUSE WAY, NORTHCOTE 0627, AUCKLAND, NEW ZEALAND
SN 1175-0561
EI 1179-1888
J9 AM J CLIN DERMATOL
JI Am. J. Clin. Dermatol.
PD OCT
PY 2015
VL 16
IS 5
BP 439
EP 445
DI 10.1007/s40257-015-0142-8
PG 7
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA CR8YO
UT WOS:000361640600008
PM 26179827
DA 2025-06-11
ER

PT J
AU Linhares, LMC
   Oliveira, CP
   Alvares-da-Silva, MR
   Stefano, JT
   Barbeiro, HV
   Barbeiro, DF
   Terrabuio, DRB
   Abdala, E
   Soriano, FG
   Carrilho, FJ
   Farias, AQ
   Siddiqui, MS
   D'Albuquerque, LAC
AF Linhares, L. M. C.
   Oliveira, C. P.
   Alvares-da-Silva, M. R.
   Stefano, J. T.
   Barbeiro, H. V.
   Barbeiro, D. F.
   Terrabuio, D. R. B.
   Abdala, E.
   Soriano, F. G.
   Carrilho, F. J.
   Farias, A. Q.
   Siddiqui, M. S.
   D'Albuquerque, L. A. C.
TI Evolution of Biomarkers of Atherogenic Risk in Liver Transplantation
   Recipients
SO TRANSPLANTATION PROCEEDINGS
LA English
DT Article
ID C-REACTIVE PROTEIN; COMPUTED-TOMOGRAPHY; METABOLIC SYNDROME; OUTCOMES;
   QUANTIFICATION; ASSOCIATION; PREDICTION; MORTALITY; DISEASE
AB Background. Cardiovascular disease is a major contributing factor to long-term mortality after liver transplantation (LT).
   Methods. This study evaluated the evolution of atherogenic risk in liver transplant recipients (LTRs). Thirty-six subjects were prospectively enrolled at 12 months and followed for 48 months after liver transplantation. Serum biomarkers of endothelial dysfunction (sICAM-1 and sVCAM-1), chronic inflammation (serum amyloid A), and oxidative stress (myeloperoxidase) were measured at 12 and 48 months after LT. Additionally, at 12 months all patients underwent a cardiac computed tomography (CT) scan and a coronary artery calcium score (CACS).
   Results. The prevalence of risk factors of metabolic syndrome (MS) increased over the course of the study. The patients' sVCAM-1 and sICAM-1 increased from 1.82 +/- 0.44 ng/mL to 9.10 +/- 5.82 ng/mL (P < .001) and 0.23 +/- 0.09 ng/mL to 2.7 +/- 3.3 ng/mL, respectively from month 12 to 48. Serum myeloperoxidase increased from 0.09 +/- 0.07 ng/mL to 3.46 +/- 3.92 ng/mL (P < .001) over the course of the study. Serum amyloid A also increased from 21.4 +/- 40.7 ng/mL at entry to 91.5 +/- 143.6 ng/mL at end of study (P < .001).
   Conclusion. No association between these biomarkers and MS was noted. The cardiac CT revealed mild and moderate disease in 19% and 25% of the cohort, respectively. No association between serum biomarkers and CACS was noted. Serum biomarkers of atherogenic risk increase rapidly in LTRs and precede coronary plaques.
C1 [Linhares, L. M. C.; Oliveira, C. P.; Stefano, J. T.; Terrabuio, D. R. B.; Abdala, E.; Carrilho, F. J.; Farias, A. Q.; D'Albuquerque, L. A. C.] Univ Sao Paulo, Sch Med, Dept Gastroenterol LIM 07 LIM 37, Sao Paulo, Brazil.
   [Alvares-da-Silva, M. R.] Univ Fed Rio Grande do Sul, Hosp Clin Porto Alegre, Div Gastroenterol, Porto Alegre, RS, Brazil.
   [Barbeiro, H. V.; Barbeiro, D. F.; Soriano, F. G.] Univ Sao Paulo, Sch Med, Div Emergency Med LIM 51, Sao Paulo, Brazil.
   [Siddiqui, M. S.] Virginia Commonwealth Univ, Div Gastroenterol & Hepatol, Med Coll Virginia Campus, Richmond, VA 23284 USA.
C3 Universidade de Sao Paulo; Universidade Federal do Rio Grande do Sul;
   Hospital de Clinicas de Porto Alegre; Universidade de Sao Paulo;
   Virginia Commonwealth University
RP Oliveira, CP (corresponding author), Univ Sao Paulo, Sch Med, Dept Gastroenterol, Av Dr Eneas Carvalho Aguiar 255,Inst Cent 9159, BR-05403000 Sao Paulo, Brazil.
EM cpm@usp.br
RI D'Albuquerque, Luiz/I-4011-2012; Barbeiro, Hermes/E-2814-2010; Soriano,
   Francisco/C-3382-2012; STEFANO, JOSE TADEU/AGR-5605-2022; Oliveira,
   Claudia/D-1216-2014; Carrilho, Flair/I-3046-2012; Queiroz Farias,
   Alberto/ABB-1291-2020; Barbeiro, Hermes/S-5926-2016; Abdala,
   Edson/H-5165-2012; Alvares-da-Silva, Mario/L-3910-2014
OI Queiroz Farias, Alberto/0000-0002-5572-663X; Carrilho, Flair
   Jose/0000-0002-7682-3105; Barbeiro, Hermes/0000-0002-8209-4463; Abdala,
   Edson/0000-0003-0765-6654; P Oliveira, Claudia/0000-0002-2848-417X;
   Carneiro D'Albuquerque, Luiz Augusto/0000-0001-7607-7168;
   Alvares-da-Silva, Mario/0000-0002-5001-246X
FU Coordination for the Improvement of Higher Education Personnel at the
   University of Sao Paulo
FX This work was supported by a scholarship funded by the Coordination for
   the Improvement of Higher Education Personnel at the University of Sao
   Paulo.
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TC 6
Z9 6
U1 1
U2 4
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0041-1345
EI 1873-2623
J9 TRANSPL P
JI Transplant. Proc.
PD DEC
PY 2018
VL 50
IS 10
BP 3650
EP 3655
DI 10.1016/j.transproceed.2018.04.030
PG 6
WC Immunology; Surgery; Transplantation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Surgery; Transplantation
GA HG4VB
UT WOS:000454972000120
PM 30586839
DA 2025-06-11
ER

PT J
AU Luna-Vital, D
   Weiss, M
   de Mejia, EG
AF Luna-Vital, Diego
   Weiss, Matthew
   de Mejia, Elvira Gonzalez
TI Anthocyanins from Purple Corn Ameliorated Tumor Necrosis
   Factor-α-Induced Inflammation and Insulin Resistance in 3T3-L1
   Adipocytes via Activation of Insulin Signaling and Enhanced GLUT4
   Translocation
SO MOLECULAR NUTRITION & FOOD RESEARCH
LA English
DT Article
DE anthocyanins; inflammation; obesity; polyphenols; purple corn
ID GLUCOSE-UPTAKE; ADIPONECTIN SECRETION; METABOLIC SYNDROME; OXIDATIVE
   STRESS; BLOOD-GLUCOSE; PPAR-GAMMA; DIFFERENTIATION; INTERLEUKIN-6;
   EXTRACT; OBESITY
AB Scope: The aim was to compare the effect of an anthocyanin-rich extract from purple corn pericarp (PCW) and pure anthocyanins on adipogenesis, inflammation, and insulin resistance in 3T3-L1 adipocytes on basal and inflammatory conditions.
   Methods and results: Preadipocytes (3T3-L1) were treated during differentiation with or without PCW. Differentiated adipocytes were treated either individually or in combination with tumor necrosis factor a (TNF-a alpha) and PCW, or pure C3G, Pr3G, P3G. PCW reduced preadipocyte differentiation (IC50 = 0.4 mg/mL). PCW and pure anthocyanins including C3G reduced fatty acid synthase enzymatic activity. PCW reduced TNF-alpha-dependent inflammatory status increasing adiponectin (39%), and decreasing leptin (-79%). PCW and C3G increased glucose uptake and reduced reactive oxygen species generation in insulin resistant adipocytes. An increase in phosphorylation was observed in AKT, IKK, and MEK, and a decrease in IRS and mTOR activating the insulin receptor-associated pathway. PCW (7.5-fold) and C3G (6.3-fold) enhanced GLUT4 membrane translocation compared to insulin resistant adipocytes.
   Conclusion: Anthocyanins from colored corn prevented adipocyte differentiation, lipid accumulation, and reduced PPAR-gamma transcriptional activity on adipocytes in basal conditions. Ameliorated TNF-alpha-induced inflammation and insulin resistance in adipocytes via activation of insulin signaling and enhanced GLUT4 translocation suggesting a reduced hyperglycemia associated with the metabolic syndrome.
C1 [Luna-Vital, Diego; de Mejia, Elvira Gonzalez] Univ Illinois, Dept Food Sci & Human Nutr, Urbana, IL 61820 USA.
   [Weiss, Matthew] Univ Illinois, Sch Mol & Cellular Biol, Urbana, IL USA.
C3 University of Illinois System; University of Illinois Urbana-Champaign;
   University of Illinois System; University of Illinois Urbana-Champaign
RP de Mejia, EG (corresponding author), Univ Illinois, Dept Food Sci & Human Nutr, Urbana, IL 61820 USA.
EM edemejia@illinois.edu
RI GONZALEZ DE mEJIA, ELVIRA/IYI-9309-2023; Luna-Vital, Diego
   A./B-9634-2015
OI Luna-Vital, Diego A./0000-0001-7734-7975; DE MEJIA,
   ELVIRA/0000-0001-7426-9035
FU University of Illinois USDA Hatch funding
FX Research was supported by University of Illinois USDA Hatch funding.
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NR 60
TC 90
Z9 91
U1 1
U2 60
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1613-4125
EI 1613-4133
J9 MOL NUTR FOOD RES
JI Mol. Nutr. Food Res.
PD DEC
PY 2017
VL 61
IS 12
AR 1700362
DI 10.1002/mnfr.201700362
PG 13
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA FP2PC
UT WOS:000417459400004
PM 28759152
DA 2025-06-11
ER

PT J
AU Tinkov, AA
   Filippini, T
   Ajsuvakova, OP
   Aaseth, J
   Gluhcheva, YG
   Ivanova, JM
   Bjorklund, G
   Skalnaya, MG
   Gatiatulina, ER
   Popova, EV
   Nemereshina, ON
   Vinceti, M
   Skalny, AV
AF Tinkov, Alexey A.
   Filippini, Tommaso
   Ajsuvakova, Olga P.
   Aaseth, Jan
   Gluhcheva, Yordanka G.
   Ivanova, Juliana M.
   Bjorklund, Geir
   Skalnaya, Margarita G.
   Gatiatulina, Eugenia R.
   Popova, Elizaveta V.
   Nemereshina, Olga N.
   Vinceti, Marco
   Skalny, Anatoly V.
TI The role of cadmium in obesity and diabetes
SO SCIENCE OF THE TOTAL ENVIRONMENT
LA English
DT Review
DE Cadmium; Adipose tissue; Insulin resistance; Obesity; Diabetes
ID INDUCED OXIDATIVE STRESS; KOREA NATIONAL-HEALTH; IMPAIRED
   GLUCOSE-TOLERANCE; NF-KAPPA-B; METABOLIC SYNDROME; URINARY CADMIUM;
   INSULIN-RESISTANCE; BLOOD CADMIUM; TOXIC METALS; INDUCED APOPTOSIS
AB Multiple studies have shown an association between environmental exposure to hazardous chemicals including toxic metals and obesity, diabetes, and metabolic syndrome. At the same time, the existing data on the impact of cadmium exposure on obesity and diabetes are contradictory. Therefore, the aim of the present work was to review the impact of cadmium exposure and status on the risk and potential etiologic mechanisms of obesity and diabetes. In addition, since an effect of cadmium exposure on incidence of diabetes mellitus and insulin resistance was suggested by several epidemiologic studies, we carried out a meta-analysis of all studies assessing risk of prevalence and incidence of diabetes. By comparing the highest versus the lowest cadmium exposure category, we found a high risk of diabetes incidence (odds ratio = 1.38, 95% confidence interval 1.12-1.71), which was higher for studies using urine as exposure assessment. On the converse, results of epidemiologic studies linking cadmium exposure and overweight or obesity are far less consistent and even conflicting, also depending on differences in exposure levels and the specific marker of exposure (blood, urine, hair, nails). In turn, laboratory studies demonstrated that cadmium adversely affects adipose tissue physiopathology through several mechanisms, thus contributing to increased insulin resistance and enhancing diabetes. However, intimate biological mechanisms linking Cd exposure with obesity and diabetes are still to be adequately investigated. (C) 2017 Elsevier B.V. All rights reserved.
C1 [Tinkov, Alexey A.; Skalny, Anatoly V.] Yaroslavl State Univ, Yaroslavl, Russia.
   [Tinkov, Alexey A.; Gatiatulina, Eugenia R.; Popova, Elizaveta V.; Nemereshina, Olga N.] Orenburg State Med Univ, Orenburg, Russia.
   [Tinkov, Alexey A.; Skalny, Anatoly V.] RUDN Univ, Moscow, Russia.
   [Ajsuvakova, Olga P.; Skalnaya, Margarita G.; Skalny, Anatoly V.] Orenburg State Pedag Univ, Orenburg, Russia.
   [Aaseth, Jan] Hedmark Univ Appl Sci, Dept Publ Hlth, Elverum, Norway.
   [Aaseth, Jan] Innlandet Hosp Trust, Res Dept, Brumunddal, Norway.
   [Gluhcheva, Yordanka G.] Bulgarian Acad Sci, Pathol & Anthropol Museum, Inst Expt Morphol, Sofia, Bulgaria.
   [Ivanova, Juliana M.] Sofia Univ St Kliment Ohridski, Fac Med, Sofia, Bulgaria.
   [Bjorklund, Geir] Council Nutr & Environm Med, Mo I Rana, Norway.
   [Gatiatulina, Eugenia R.] South Ural State Med Univ, Chelyabinsk, Russia.
   [Filippini, Tommaso; Vinceti, Marco] Univ Modena & Reggio Emilia, CREAGEN Environm Genet & Nutr Epidemiol Res Ctr, Modena, Italy.
   [Popova, Elizaveta V.] St Joseph Univ Tanzania, St Joseph Coll Hlth Sci, Dar Es Salaam, Tanzania.
C3 Yaroslavl State University; Peoples Friendship University of Russia;
   Orenburg State Pedagogical University; Innlandet Hospital Trust;
   Bulgarian Academy of Sciences; University of Sofia; Medical University
   Sofia; South Ural State Medical University; Universita di Modena e
   Reggio Emilia
RP Tinkov, AA (corresponding author), Yaroslavl State Univ, Yaroslavl, Russia.
EM tinkov.a.a@gmail.com
RI Ajsuvakova, Olga/N-6595-2016; Ivanova, Juliana/HGA-1586-2022; Aaseth,
   Jan/J-6764-2017; Nikonorova, Eugenia/AAQ-5445-2020; Vinceti,
   Marco/O-2509-2015; Skalny, Anatoly/J-3953-2019; Tinkov,
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OI Ajsuvakova, Olga/0000-0003-4707-9353; Nikonorova,
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   Juliana/0000-0002-3213-2046; Filippini, Tommaso/0000-0003-2100-0344;
   Popova, Elizabeth/0000-0001-6703-4756; Bjorklund,
   Geir/0000-0003-2632-3935; Skalny, Anatoly/0000-0001-7838-1366
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NR 167
TC 205
Z9 216
U1 1
U2 191
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0048-9697
EI 1879-1026
J9 SCI TOTAL ENVIRON
JI Sci. Total Environ.
PD DEC 1
PY 2017
VL 601
BP 741
EP 755
DI 10.1016/j.scitotenv.2017.05.224
PG 15
WC Environmental Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology
GA FB7BA
UT WOS:000406294900073
PM 28577409
DA 2025-06-11
ER

PT J
AU Wong, CY
   O'Moore-Sullivan, T
   Fang, ZY
   Haluska, B
   Leano, R
   Marwick, TH
AF Wong, CY
   O'Moore-Sullivan, T
   Fang, ZY
   Haluska, B
   Leano, R
   Marwick, TH
TI Myocardial and vascular dysfunction and exercise capacity in the
   metabolic syndrome
SO AMERICAN JOURNAL OF CARDIOLOGY
LA English
DT Article
ID CARDIOVASCULAR-DISEASE MORTALITY; INSULIN-RESISTANCE; ADIPOSE-TISSUE;
   PULSE PRESSURE; RISK; OBESITY; STIFFNESS; INDEX; MASS
AB The metabolic syndrome (MS) is associated with cardiovascular risk exceeding that expected from atherosclerotic risk factors, but the mechanism of this association is unclear. We sought to determine the effects of the MS on myocardial and vascular function and cardiorespiratory fitness in 393 subjects with significant risk factors but no cardiovascular disease and negative stress echocardiographic findings. Myocardial function was assessed by global strain rate, strain, and regional systolic velocity (s(m)) and diastolic velocity (e(m)) using tissue Doppler imaging. Arterial compliance was assessed using the pulse pressure method, involving simultaneous radial applanation tonometry and echocardiographic measurement of stroke volume. Exercise capacity was measured by expired gas analysis. Significant and incremental variations in left ventricular systolic (s(m), global strain, and strain rate) and diastolic (e(m)) function were found according to the number of components of MS (p <0.001). MS contributed to reduced systolic and diastolic function even in those without left ventricular hypertrophy (p <0.01). A similar dose-response association was present between the number of components of the MS and exercise capacity (p <0.001) and arterial compliance. The global strain rate and em were independent predictors of exercise capacity. In conclusion, subclinical left ventricular dysfunction corresponded to the degree of metabolic burden, and these myocardial changes were associated with reduced cardiorespiratory fitness.' Subjects with MS who also have subclinical myocardial abnormalities and reduced cardiorespiratory fitness may have a higher risk of cardiovascular disease events and heart failure. (C) 2005 Elsevier Inc. All rights reserved.
C1 Univ Queensland, Brisbane, Qld, Australia.
C3 University of Queensland
RP Univ Queensland, Brisbane, Qld, Australia.
EM tmarwick@soms.uq.edu.au
RI Marwick, Thomas/AAK-3869-2021; Haluska, Brian/B-9128-2009; Marwick,
   Thomas/C-7261-2013
OI Marwick, Thomas/0000-0001-9065-0899
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NR 27
TC 71
Z9 81
U1 0
U2 0
PU EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
PI BRIDGEWATER
PA 685 ROUTE 202-206 STE 3, BRIDGEWATER, NJ 08807 USA
SN 0002-9149
EI 1879-1913
J9 AM J CARDIOL
JI Am. J. Cardiol.
PD DEC 15
PY 2005
VL 96
IS 12
BP 1686
EP 1691
DI 10.1016/j.amjcard.2005.07.091
PG 6
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 997BR
UT WOS:000234220500014
PM 16360358
DA 2025-06-11
ER

PT J
AU Boumezough, K
   Alami, M
   Oubaouz, J
   Morvaridzadeh, M
   Zoubdane, N
   Khalil, A
   Ramchoun, M
   Zahir, I
   Ramassamy, C
   Fulop, T
   Berrougui, H
AF Boumezough, Kaoutar
   Alami, Mehdi
   Oubaouz, Jamal
   Morvaridzadeh, Mojgan
   Zoubdane, Nada
   Khalil, Abdelouahed
   Ramchoun, M'hamed
   Zahir, Ilham
   Ramassamy, Charles
   Fulop, Tamas
   Berrougui, Hicham
TI Potential health benefits of olive oil polyphenols in metabolic
   disorders management
SO PHARMANUTRITION
LA English
DT Article
DE Virgin olive oil; Phenolic compound; Metabolic disorder;
   Atherosclerosis; Antioxidant; Anti-inflammatory
ID BLOOD MONONUCLEAR-CELLS; PHENOLIC-COMPOUNDS; INFLAMMATORY RESPONSE;
   MEDITERRANEAN DIET; LIPID PROFILE; IN-VIVO; CHOLESTEROL EFFLUX;
   HYDROXYTYROSOL; EXPRESSION; RICH
AB Background: The protective effects of olive oil (OO) on metabolic health. Current research aims to elucidate the positive impacts of OO on emerging factors linked to metabolic diseases such as metabolic syndrome, obesity, and type 2 diabetes. These factors encompass inflammation, oxidative stress, platelet aggregation, coagulation, endothelial function, and lipid profile. Methods: A comprehensive literature search was conducted using various electronic databases, including PubMed, Google Scholar, Scopus, and Web of Science, using the following keywords and combined synonyms: ("extra virgin olive oil"; "virgin olive oil"; "metabolic syndrome"; " type 2 diabetes"; "diabetes mellitus"; " obesity"; "atherosclerosis"; "Olive oil phenolic compounds"; "Olive oil polyphenols"; " antioxidant activity"; and "Anti-inflammatory activity"). Conclusion: Multiple studies have demonstrated that a diet rich in OO can aid in preventing atherosclerosis primarily by enhancing lipid profile. These favourable effects of OO are mainly ascribed to its abundance of phenolic compounds (PCs). Therefore, the bioactivity of olive oil phenolic compounds (OOPCs) could be related to various pharmacological characteristics such as antioxidant, anti-inflammatory, antimicrobial, antiatherogenic, antithrombotic, antimutagenic, and hypoglycemic properties. Hydroxytyrosol (HT), tyrosol (Tr), Oleuropein (OLP), Oleocanthal (OLC), and Oleacein (OLE) are the PCs mainly involved in the antioxidant and anti-inflammatory activities. This review focuses on appraising the current knowledge on the effect of OO, particularly its PCs, on metabolic diseases and discussing the underlying mechanism by which it exerts its effect.
C1 [Boumezough, Kaoutar; Alami, Mehdi; Oubaouz, Jamal; Ramchoun, M'hamed; Zahir, Ilham; Berrougui, Hicham] Sultan Moulay Sliman Univ, Polydisciplinary Fac, Dept Biol, Beni Mellal, Morocco.
   [Alami, Mehdi; Morvaridzadeh, Mojgan; Zoubdane, Nada; Khalil, Abdelouahed; Fulop, Tamas] Univ Sherbrooke, Fac Med & Hlth Sci, Geriatr Serv, Dept Med, Sherbrooke, PQ, Canada.
   [Ramassamy, Charles] INRS Ctr Armand Frappier St Biotechnol, Laval, PQ, Canada.
C3 Sultan Moulay Slimane University of Beni Mellal; University of
   Sherbrooke
RP Berrougui, H (corresponding author), Sultan Moulay Sliman Univ, Polydisciplinary Fac, Dept Biol, Beni Mellal, Morocco.
EM hichamberg@gmail.com
RI Morvaridzadeh, Mojgan/GLU-6418-2022; Ramassamy, Charles/LZH-2169-2025
FU Agence Nationale des Plantes Medicinales et Aromatiques; Centre National
   de Recherche Scientifique et Technique; Universite Sultan Moulay
   Slimane, Morocco; Canadian Institutes of Health Research [PJT-162366]
FX This research was funded by (Agence Nationale des Plantes Medicinales et
   Aromatiques), (Centre National de Recherche Scientifi-que et Technique)
   and (Universite Sultan Moulay Slimane), Morocco. 2020-2023 (H.B.) and by
   Canadian Institutes of Health Research (grant Number #PJT-162366) (A.K.)
   .
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NR 123
TC 1
Z9 1
U1 4
U2 4
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2213-4344
J9 PHARMANUTRITION
JI PharmaNutrition
PD MAR
PY 2025
VL 31
AR 100428
DI 10.1016/j.phanu.2024.100428
EA DEC 2024
PG 13
WC Chemistry, Medicinal; Geriatrics & Gerontology; Gerontology; Nutrition &
   Dietetics; Pharmacology & Pharmacy
WE Emerging Sources Citation Index (ESCI)
SC Pharmacology & Pharmacy; Geriatrics & Gerontology; Nutrition & Dietetics
GA W7Q1B
UT WOS:001420463200001
DA 2025-06-11
ER

PT J
AU Kwon, Y
AF Kwon, Youngjoo
TI Immuno-Resolving Ability of Resolvins, Protectins, and Maresins Derived
   from Omega-3 Fatty Acids in Metabolic Syndrome
SO MOLECULAR NUTRITION & FOOD RESEARCH
LA English
DT Review
DE inflammation; insulin sensitivity; maresins; metabolic syndrome;
   obesity; omega-3 fatty acids; protectins; resolvins
ID PRORESOLVING LIPID MEDIATORS; ADIPOSE-TISSUE MACROPHAGES; N-3
   FATTY-ACIDS; TYPE-2 DIABETES-MELLITUS; INSULIN-RESISTANCE;
   DOCOSAHEXAENOIC ACID; NLRP3 INFLAMMASOME; FISH-OIL; ANTIINFLAMMATORY
   PROPERTIES; OXIDATIVE STRESS
AB Omega-3 fatty acid consumption has been suggested to be beneficial for the prevention of type 2 diabetes mellitus (T2DM). Its effects have been attributed to anti-inflammatory activity, with the inhibition of arachidonic acid metabolism playing a central role. However, a more recent view is that omega-3 fatty acids play an active role as the precursors of potent, specialized pro-resolving mediators (SPMs), such as resolvins, protectins, and maresins. Docosahexaenoic acid (DHA)- and eicosapentaenoic-acid-derived SPMs are identified in the adipose tissue but the levels of certain SPMs (e.g., protectin D1) are markedly reduced with obesity, suggesting adipose SPM deficiency, potentially resulting in unresolved inflammation. Supplementation of the biosynthetic intermediates of SPM (e.g., 17-hydroxy-DHA) or omega-3 fatty acids increases the level of adipose SPMs, reduces adipose inflammation (decrease in macrophage accumulation and change to less inflammatory macrophages), and enhances insulin sensitivity. The findings from studies using rodent obesity models must be translated to humans. It will be important to further elucidate the underlying mechanisms by which obesity reduces the levels of and the sensitivity to SPM in adipose tissues. This will enable the development of nutrition therapy to enhance the effects of omega-3 fatty acids in the prevention and/or treatment of T2DM.
C1 [Kwon, Youngjoo] Ewha Womans Univ, Dept Food Sci & Engn, Seoul 03760, South Korea.
C3 Ewha Womans University
RP Kwon, Y (corresponding author), Ewha Womans Univ, Dept Food Sci & Engn, Seoul 03760, South Korea.
EM Youngjoo.Kwon@ewha.ac.kr
OI Kwon, Youngjoo/0000-0003-3582-4192
FU National Research Foundation of Korea (NRF) - Ministry of Science, ICT
   and Future Planning [2017R1D1A1B03034185]
FX This study was supported by a grant from the National Research
   Foundation of Korea (NRF), funded by the Ministry of Science, ICT and
   Future Planning (2017R1D1A1B03034185).
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NR 100
TC 54
Z9 57
U1 7
U2 30
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1613-4125
EI 1613-4133
J9 MOL NUTR FOOD RES
JI Mol. Nutr. Food Res.
PD FEB
PY 2020
VL 64
IS 4
SI SI
AR 1900824
DI 10.1002/mnfr.201900824
EA DEC 2019
PG 12
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA KQ7RG
UT WOS:000502701500001
PM 31797565
DA 2025-06-11
ER

PT J
AU Narce, M
   Bellenger, J
   Rialland, M
   Bellenger, S
AF Narce, Michel
   Bellenger, Jerome
   Rialland, Mickael
   Bellenger, Sandrine
TI Recent Advances on Stearoyl-Coa Desaturase Regulation in Fatty Liver
   Diseases
SO CURRENT DRUG METABOLISM
LA English
DT Review
DE Stearoyl-CoA desaturase; fatty acids; nonalcoholic steatohepatitis;
   alcoholic steatohepatitis; inflammation; obesity-metabolic syndrome
ID CONJUGATED LINOLEIC-ACID; SPONTANEOUSLY HYPERTENSIVE-RATS; PURIFIED
   EICOSAPENTAENOIC ACID; ENDOPLASMIC-RETICULUM STRESS; ELEMENT-BINDING
   PROTEIN-1C; OBESE ZUCKER RATS; MIDDLE-AGED MEN; HEPATIC STEATOSIS;
   INSULIN SENSITIVITY; METABOLIC SYNDROME
AB Stearoyl-CoA desaturase 1 (SCD-1) is a delta-9 fatty acid desaturase that catalyzes the synthesis of monounsaturated fatty acids. Indeed, SCD-1 is the critical control point regulating hepatic lipogenesis and lipid oxidation. Due to its central role in lipid metabolism in the liver, recent studies have focused on the involvement of SCD-1 in the development of fatty liver during obesity, diabetes mellitus, hypertension, excessive alcohol consumption, and in subjects with high triglyceride blood concentrations. The accumulation of fat in liver cells can be a sign that harmful conditions are developing, possibly associated with or leading to inflammation of the liver.
   This review evaluates the recent advances in our understanding of the regulation of SCD-1 expression and its role in the development of nonalcoholic and alcoholic hepatosteatosis. Animal models presenting a liver-specific loss or inhibition of SCD-1, as well as dietary interventions, have highlighted the important role of the enzyme in the accumulation of fat (fatty infiltration) in hepatocytes during both alcoholic and nonalcoholic liver diseases. The data summarized in this article support the notion that SCD-1 plays a direct role in the development of fatty liver diseases, and is not simply a marker of an unfavorable diet or hepatic disorder. Accordingly, SCD-1 represents a promising therapeutic target for the treatment of hepatic steatosis.
C1 [Narce, Michel; Bellenger, Jerome; Rialland, Mickael; Bellenger, Sandrine] Univ Bourgogne, UFR Sci Vie Terre & Environm, F-21000 Dijon, France.
   [Narce, Michel; Bellenger, Jerome; Rialland, Mickael; Bellenger, Sandrine] Univ Bourgogne, INSERM, UMR Lipides Nutr Canc U866, F-21000 Dijon, France.
C3 Universite Bourgogne Europe; Institut National de la Sante et de la
   Recherche Medicale (Inserm); Universite Bourgogne Europe
RP Narce, M (corresponding author), Univ Bourgogne, INSERM, UMR 866, 6 Bd Gabriel, F-21000 Dijon, France.
EM michel.narce@u-bourgogne.fr
RI BELLENGER, Jerome/AAC-9423-2022
OI Narce, Michel/0000-0002-9986-6247; Rialland,
   Mickael/0000-0001-9693-9351; Bellenger, Sandrine/0000-0002-4593-5454
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NR 102
TC 20
Z9 21
U1 0
U2 24
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1389-2002
EI 1875-5453
J9 CURR DRUG METAB
JI Curr. Drug Metab.
PD DEC
PY 2012
VL 13
IS 10
BP 1454
EP 1463
DI 10.2174/138920012803762693
PG 10
WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
GA 052NC
UT WOS:000312203600009
PM 22978399
DA 2025-06-11
ER

PT J
AU Ronconi, V
   Turchi, F
   Appolloni, G
   di Tizio, V
   Boscaro, M
   Giacchetti, G
AF Ronconi, Vanessa
   Turchi, Federica
   Appolloni, Gloria
   di Tizio, Valentina
   Boscaro, Marco
   Giacchetti, Gilberta
TI Aldosterone, Mineralocorticoid Receptor and the Metabolic Syndrome: Role
   of the Mineralocorticoid Receptor Antagonists
SO CURRENT VASCULAR PHARMACOLOGY
LA English
DT Article
DE Aldosterone; metabolic syndrome; mineralocorticoid receptor;
   mineralocorticoid receptor antagonists
ID RENIN-ANGIOTENSIN SYSTEM; ADIPOSE-TISSUE; INSULIN-RESISTANCE;
   PLASMA-ALDOSTERONE; SKELETAL-MUSCLE; PRIMARY HYPERALDOSTERONISM;
   BLOOD-PRESSURE; CARDIOMETABOLIC SYNDROME; OBESITY-HYPERTENSION;
   NONGENOMIC ACTIONS
AB Several lines of evidence suggest a detrimental effect of aldosterone excess on the development of metabolic alterations. Glucose metabolism derangements due to aldosterone action are frequently observed not only in patients with primary aldosteronism but also in patients with obesity. A contribution to the hyperaldosteronism observed in obese subjects can be attributed, at least in part, to the action of still unidentified adipocyte-derived factor. Aldosterone, through genomic and non-genomic actions contributes to induce several abnormalities: pancreatic fibrosis, impaired beta cell function, as well as reduced skeletal muscle and adipose tissue insulin sensitivity. Oxidative stress, systemic inflammation, together with these metabolic alterations may explain the appearance of the cardiometabolic syndrome and the progression of cardiovascular and renal diseases, in the presence of inappropriate aldosterone levels. The biological actions of aldosterone are mediated by mineralocorticoid receptor (MR), although MR can be activated through an aldosterone-independent fashion. Besides salt-water homeostasis, MR activation promotes inflammation, endothelial dysfunction, cardiovascular remodelling and affects adipose tissue differentiation and function.
   Clinical and experimental studies have shown that MR blockade is able to suppress inflammation, to improve endothelium-dependent vasorelaxation, but most interestingly, to improve pancreatic insulin release as well as insulin-mediated glucose utilization. These actions indicate MR antagonists as a useful therapeutic tool able not only to reduce cardiovascular risk and renal damage, but also to improve metabolic sequaelae.
C1 [Ronconi, Vanessa; Turchi, Federica; Appolloni, Gloria; di Tizio, Valentina; Boscaro, Marco; Giacchetti, Gilberta] Univ Politecn Marche, Div Endocrinol, Azienda Osped Univ, Osped Riuniti Umberto I GM Lancisi G Salesi, I-60126 Ancona, Italy.
C3 Marche Polytechnic University
RP Giacchetti, G (corresponding author), Univ Politecn Marche, Div Endocrinol, Osped Riuniti, Via Conca 71, I-60126 Ancona, Italy.
EM g.giacchetti@ospedaliriuniti.marche.it
RI GIACCHETTI, Gilberta/AAF-1074-2020
OI Ronconi, Vanessa/0000-0003-3100-076X; BOSCARO,
   MARCO/0000-0003-2596-1652; Giacchetti, Gilberta/0000-0002-3942-1748
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NR 118
TC 21
Z9 22
U1 0
U2 5
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1570-1611
EI 1875-6212
J9 CURR VASC PHARMACOL
JI Current Vascular Pharmacology
PD MAR
PY 2012
VL 10
IS 2
BP 238
EP 246
DI 10.2174/157016112799304969
PG 9
WC Pharmacology & Pharmacy; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Cardiovascular System & Cardiology
GA 897HX
UT WOS:000300640600012
PM 22022770
DA 2025-06-11
ER

PT J
AU Dlamini, BS
   Hernandez, CE
   Chen, CR
   Shih, WL
   Hsu, JL
   Chang, CI
AF Dlamini, Bongani Sicelo
   Hernandez, Carlos Eduardo
   Chen, Chiy-Rong
   Shih, Wen-Ling
   Hsu, Jue-Liang
   Chang, Chi-, I
TI In vitro antioxidant, antiglycation, and enzymatic inhibitory
   activity against α-glucosidase, α-amylase, lipase and HMG-CoA reductase
   of Terminalia boivinii Tul
SO BIOCATALYSIS AND AGRICULTURAL BIOTECHNOLOGY
LA English
DT Article
DE Antioxidant; Enzyme inhibition activity; Phytochemical analysis;
   Terminalia boivinii Tul
ID BIOLOGICAL-ACTIVITIES; OXIDATIVE STRESS; CHEMICAL-COMPOSITION; METABOLIC
   SYNDROME; PHENOLIC-COMPOUNDS; EXTRACTS; PLANTS; IDENTIFICATION;
   INFECTIONS
AB Phytoantioxidants from Terminalia boivinii Tul. are of medical interest given their potential inhibitory capacity against the formation of glycation end products and key enzymes associated with metabolic syndrome. The present study investigated and compared the polyphenolic content and biological properties of ethyl acetate, n-butanol and aqueous solvent fractions of T. boivinii fruits, leaves, stem and bark methanolic extracts. The total bioactive content of the tested materials was evaluated by spectrophotometric methods. The antioxidant activity was analyzed using DPPH, superoxide anion radical, metal chelation and FRAP assays. The enzyme inhibitory properties were tested on alpha-glucosidase, alpha-amylase, lipase and HMG-CoA reductase enzymes, while antiglycation activities were evaluated by the bovine serum albumin (BSA) - methylglyoxal (MG) method. Phytochemical analysis indicated that the ethyl acetate fractions had high levels of phenols (40.58 +/- 2.94 mg GAE/g DW of leaves) and flavonoids (20.32 +/- 1.62 mg QE/g DW of leaves) compared to the other extracts, which is directly related with their significant antiradical, reducing power, alpha-glucosidase, lipase and HMG-CoA reductase inhibitory ability. However, the water fraction with the lowest polyphenol content was more active in metal chelation. Moreover, the antiglycation activities followed a similar pattern to the radical scavenging activities. Our results showed that T. boivinii is a viable source of natural bioactive antioxidant and enzymeinhibiting chemicals that maybe considered for commercial exploitation.
C1 [Dlamini, Bongani Sicelo] Natl Pingtung Univ Sci & Technol, Dept Trop Agr & Int Cooperat, Pingtung 91201, Taiwan.
   [Hernandez, Carlos Eduardo] Natl Univ UNA, Sch Agr Sci, Lab Food Qual Innovat, Heredia, Costa Rica.
   [Chen, Chiy-Rong] Natl Taitung Univ, Dept Life Sci, Taitung 95002, Taiwan.
   [Shih, Wen-Ling; Hsu, Jue-Liang; Chang, Chi-, I] Natl Pingtung Univ Sci & Technol, Dept Biol Sci & Technol, Pingtung 91201, Taiwan.
   [Hsu, Jue-Liang] Natl Pingtung Univ Sci & Technol, Res Ctr Austronesian Med & Agr, Pingtung 91201, Taiwan.
   [Hsu, Jue-Liang] Natl Pingtung Univ Sci & Technol, Res Ctr Trop Agr, Pingtung 91201, Taiwan.
   [Chang, Chi-, I] Natl Pingtung Univ Sci & Technol, Res Ctr Act Nat Prod Dev, Pingtung 91201, Taiwan.
C3 National Pingtung University Science & Technology; Universidad Nacional
   Costa Rica; National Pingtung University Science & Technology; National
   Pingtung University Science & Technology; National Pingtung University
   Science & Technology; National Pingtung University Science & Technology
RP Chang, CI (corresponding author), Natl Pingtung Univ Sci & Technol, Dept Biol Sci & Technol, Pingtung 91201, Taiwan.
EM changchii@mail.npust.edu.tw
RI Hernandez, Carlos/CAG-5371-2022
OI Hernandez, Carlos Eduardo/0000-0002-0059-8028; Dlamini, Bongani
   Sicelo/0000-0002-4735-4741; Hsu, Jue-Liang/0000-0002-6771-6690
FU Ministry of Science and Technology, Taiwan [MOST 105-2320-B-020-002-MY3,
   MOST 108-2320-B-020-003, MOST 109-2320-B-020-001]
FX Ministry of Science and Technology, Taiwan (MOST 105-2320-B-020-002-MY3,
   MOST 108-2320-B-020-003, and MOST 109-2320-B-020-001) .
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NR 64
TC 6
Z9 6
U1 0
U2 5
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
EI 1878-8181
J9 BIOCATAL AGR BIOTECH
JI Biocatal. Agric. Biotechnol.
PD JAN
PY 2022
VL 39
AR 102235
DI 10.1016/j.bcab.2021.102235
EA DEC 2021
PG 12
WC Biotechnology & Applied Microbiology
WE Emerging Sources Citation Index (ESCI)
SC Biotechnology & Applied Microbiology
GA XK9EW
UT WOS:000727760300001
DA 2025-06-11
ER

PT J
AU Peyter, AC
   Armengaud, JB
   Guillot, E
   Yzydorczyk, C
AF Peyter, Anne-Christine
   Armengaud, Jean-Baptiste
   Guillot, Estelle
   Yzydorczyk, Catherine
TI Endothelial Progenitor Cells Dysfunctions and Cardiometabolic Disorders:
   From Mechanisms to Therapeutic Approaches
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE developmental programming; intrauterine growth restriction; metabolic
   syndrome; endothelial progenitor cells; oxidative stress; cellular
   senescence
ID NITRIC-OXIDE SYNTHASE; INTRAUTERINE GROWTH RESTRICTION;
   LOW-BIRTH-WEIGHT; SYSTOLIC BLOOD-PRESSURE; COLONY-FORMING CELLS; FATTY
   LIVER-DISEASE; PULMONARY ARTERIAL-HYPERTENSION; ACTIVATED
   PROTEIN-KINASE; TYPE-2 DIABETES-MELLITUS; FLOW-MEDIATED DILATION
AB Metabolic syndrome (MetS) is a cluster of several disorders, such as hypertension, central obesity, dyslipidemia, hyperglycemia, insulin resistance and non-alcoholic fatty liver disease. Despite health policies based on the promotion of physical exercise, the reduction of calorie intake and the consumption of healthy food, there is still a global rise in the incidence and prevalence of MetS in the world. This phenomenon can partly be explained by the fact that adverse events in the perinatal period can increase the susceptibility to develop cardiometabolic diseases in adulthood. Individuals born after intrauterine growth restriction (IUGR) are particularly at risk of developing cardiovascular diseases (CVD) and metabolic disorders later in life. It has been shown that alterations in the structural and functional integrity of the endothelium can lead to the development of cardiometabolic diseases. The endothelial progenitor cells (EPCs) are circulating components of the endothelium playing a major role in vascular homeostasis. An association has been found between the maintenance of endothelial structure and function by EPCs and their ability to differentiate and repair damaged endothelial tissue. In this narrative review, we explore the alterations of EPCs observed in individuals with cardiometabolic disorders, describe some mechanisms related to such dysfunction and propose some therapeutical approaches to reverse the EPCs dysfunction.
C1 [Peyter, Anne-Christine] Univ Lausanne Hosp, Dept Woman Mother Child, Clin Neonatol, Neonatal Res Lab, CH-1011 Lausanne, Switzerland.
   [Peyter, Anne-Christine; Armengaud, Jean-Baptiste; Guillot, Estelle; Yzydorczyk, Catherine] Univ Lausanne, Fac Biol & Med, CH-1011 Lausanne, Switzerland.
   [Armengaud, Jean-Baptiste; Guillot, Estelle; Yzydorczyk, Catherine] Univ Lausanne Hosp, Div Pediat, Dept Woman Mother Child, DOHaD Lab, CH-1011 Lausanne, Switzerland.
C3 University of Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV);
   University of Lausanne; University of Lausanne; Centre Hospitalier
   Universitaire Vaudois (CHUV)
RP Yzydorczyk, C (corresponding author), Univ Lausanne, Fac Biol & Med, CH-1011 Lausanne, Switzerland.; Yzydorczyk, C (corresponding author), Univ Lausanne Hosp, Div Pediat, Dept Woman Mother Child, DOHaD Lab, CH-1011 Lausanne, Switzerland.
EM Anne-Christine.Peyter@chuv.ch; jean-baptiste.armengaud@chuv.ch;
   estelle.guillot@unil.ch; catherine.yzydorczyk@chuv.ch
OI Armengaud, Jean-Baptiste/0000-0002-2276-623X; Peyter,
   Anne-Christine/0000-0003-2051-1126; YZYDORCZYK,
   Catherine/0000-0002-0617-7558
FU "Association pour l'information et la recherche sur les maladies renales
   genetiques" (AIRG-Suisse)
FX This research was funded by grant from the "Association pour
   l'information et la recherche sur les maladies renales genetiques"
   (AIRG-Suisse).
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NR 333
TC 31
Z9 31
U1 1
U2 11
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD JUL
PY 2021
VL 22
IS 13
AR 6667
DI 10.3390/ijms22136667
PG 27
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA TG4RD
UT WOS:000671393000001
PM 34206404
OA Green Published
DA 2025-06-11
ER

PT J
AU Katsiki, N
   Doumas, M
   Mikhailidis, DP
AF Katsiki, Niki
   Doumas, Michael
   Mikhailidis, Dimitri P.
TI Lipids, Statins and Heart Failure: An Update
SO CURRENT PHARMACEUTICAL DESIGN
LA English
DT Review
DE Statins; heart failure; lipids; trials; cardiovascular risk factors;
   metabolic syndrome; non-alcoholic fatty liver disease
ID FATTY LIVER-DISEASE; SERUM URIC-ACID; CHRONIC KIDNEY-DISEASE;
   HIGH-DENSITY-LIPOPROTEIN; SUDDEN CARDIAC DEATH; PERCUTANEOUS CORONARY
   INTERVENTION; LEFT-VENTRICULAR HYPERTROPHY; EPICARDIAL ADIPOSE-TISSUE;
   POSTOPERATIVE ATRIAL-FIBRILLATION; GLOMERULAR-FILTRATION-RATE
AB Background: Heart failure (HF) is characterized by cardiac functional and structural alterations, progressively leading to clinical symptoms and signs. Certain neurohormonal systems (i.e. the sympathetic nervous system, the renin-angiotensin-aldosterone system and the natriuretic peptide system) as well as interactions between endothelial, monocytes/macrophages and myocardial cells are involved in the process.
   Methods: The present narrative review discusses the relationships between lipids, statins and HF.
   Results: Lipid metabolism is involved in cardiac function. Inflammation, oxidative stress, endothelial and platelet dysfunction, activation of neurohormonal systems, adverse cardiac remodeling, haemodynamic disorders and arrhythmogenesis predispose to HF development and progression. Statins have been shown to reduce HF incidence possibly via their pleiotropic actions on the above mentioned mechanisms. Other cardiovascular (CV) risk factors affecting HF prevalence and outcomes include metabolic syndrome, non-alcoholic fatty liver disease, chronic kidney disease, hyperuricaemia, epicardial fat and increased arterial stiffness that are improved following statin therapy.
   Conclusion: Lipid disorders are involved in HF development and progression. Statins may beneficially affect these disorders as well as other CV risk factors linked to HF. However, the impact of statins in patients with established HF has yet to be determined. Further studies are needed to unveil potential benefits of statin therapy (or some statins) in specific groups of HF patients.
C1 [Katsiki, Niki; Doumas, Michael] Aristotle Univ Thessaloniki, Sch Med, Hippokration Hosp, Propedeut Dept Internal Med 2, Thessaloniki 55132, Greece.
   [Mikhailidis, Dimitri P.] UCL, Sch Med, Dept Clin Biochem, Vasc Dis Prevent Clin, Royal Free Hosp Campus,Pond St, London NW3 2QG, England.
C3 Aristotle University of Thessaloniki; University of London; University
   College London; UCL Medical School; Royal Free London NHS Foundation
   Trust
RP Mikhailidis, DP (corresponding author), UCL, Sch Med, Dept Clin Biochem, Vasc Dis Prevent Clin, Royal Free Hosp Campus,Pond St, London NW3 2QG, England.
EM mikhailidis@aol.com
RI Mikhailidis, Dimitri/A-1869-2013; KATSIKI, NIKI/ADE-7999-2022
OI KATSIKI, NIKI/0000-0003-0894-2644; Doumas, Michael/0000-0002-7269-8044
FU MSD; AstraZeneca; Novartis; Amgen; Sanofi; Novo Nordisk; Libytec
FX This review was written independently; no company or institution
   supported the authors financially or by providing a professional writer.
   NK has given talks, attended conferences and participated in trials
   sponsored by MSD, AstraZeneca, Novartis, Amgen, Sanofi, Novo Nordisk and
   Libytec. MD has nothing to declare. DPM has given talks and attended
   conferences sponsored by MSD, AstraZeneca and Libytec.
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NR 260
TC 24
Z9 25
U1 0
U2 23
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1381-6128
EI 1873-4286
J9 CURR PHARM DESIGN
JI Curr. Pharm. Design
PY 2016
VL 22
IS 31
BP 4796
EP 4806
DI 10.2174/1381612822666160701073452
PG 11
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA EA9BB
UT WOS:000386934100006
PM 27396601
DA 2025-06-11
ER

PT J
AU Yesil, A
   Yilmaz, Y
AF Yesil, A.
   Yilmaz, Y.
TI Review article: coffee consumption, the metabolic syndrome and
   non-alcoholic fatty liver disease
SO ALIMENTARY PHARMACOLOGY & THERAPEUTICS
LA English
DT Review
ID ANTIOXIDANT PROPERTIES; OXIDATIVE STRESS; CAFFEINE CONSUMPTION;
   AMSTERDAM GROWTH; HABITUAL COFFEE; HEALTH; RISK; STEATOHEPATITIS;
   ASSOCIATION; POLYPHENOLS
AB BackgroundCoffee consumption may modulate the risk of the metabolic syndrome (MetS) and non-alcoholic fatty liver disease (NAFLD).
   AimTo review the experimental, epidemiological and clinical studies investigating the association between coffee consumption and the risk of MetS and NAFLD.
   MethodsA literature search was conducted with the aim of finding original experimental, epidemiological and clinical articles on the association between coffee consumption, MetS and NAFLD. The following databases were used: PubMed, Embase, Scopus and Science Direct. We included articles written in English and published up to July 2013.
   ResultsThree experimental animal studies investigated the effects of coffee in the MetS, whereas five examined whether experimental coffee intake may modulate the risk of fatty liver infiltration. All of the animal studies showed a protective effect of coffee towards the development of MetS and NAFLD. Moreover, we identified eleven epidemiological and clinical studies that met the inclusion criteria. Of them, six were carried out on the risk of the MetS and five on the risk of NAFLD. Four of the six studies reported an inverse association between coffee consumption and the risk of MetS. The two studies showing negative results were from the same study cohort consisting of young persons with a low prevalence of the MetS. All of the epidemiological and clinical studies on NAFLD reported a protective effect of coffee intake.
   ConclusionsCoffee intake can reduce the risk of NAFLD. Whether this effect may be mediated by certain components of the MetS deserves further investigation.
C1 [Yesil, A.] Haydarpasa Numune Educ & Res Hosp, Dept Gastroenterol, Istanbul, Turkey.
   [Yilmaz, Y.] Marmara Univ, Inst Gastroenterol, TR-34840 Istanbul, Turkey.
   [Yilmaz, Y.] Marmara Univ, Dept Gastroenterol, Sch Med, TR-34840 Istanbul, Turkey.
C3 Istanbul Haydarpasa Numune Training & Research Hospital; Marmara
   University; Marmara University
RP Yilmaz, Y (corresponding author), Marmara Univ, Inst Gastroenterol, PK 53, TR-34840 Istanbul, Turkey.
EM dryusufyilmaz@gmail.com
RI Yilmaz, Yusuf/K-6651-2012
OI Yilmaz, Yusuf/0000-0003-4518-5283
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NR 45
TC 45
Z9 46
U1 1
U2 37
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0269-2813
EI 1365-2036
J9 ALIMENT PHARM THER
JI Aliment. Pharmacol. Ther.
PD NOV
PY 2013
VL 38
IS 9
BP 1038
EP 1044
DI 10.1111/apt.12489
PG 7
WC Gastroenterology & Hepatology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Pharmacology & Pharmacy
GA 230TC
UT WOS:000325364700004
PM 24024834
OA Green Submitted, Bronze
DA 2025-06-11
ER

PT J
AU Reza-Zaldivar, EE
   Jacobo-Velázquez, DA
AF Reza-Zaldivar, Edwin Estefan
   Jacobo-Velazquez, Daniel A.
TI Evaluating bioactivity retention in metabolism: a comparative study of
   chlorogenic acid and its metabolite dihydrocaffeic acid on antioxidant,
   anti-inflammatory, and anti-obesogenic activities in vitro
SO CYTA-JOURNAL OF FOOD
LA English
DT Article
DE Chlorogenic acid; dihydrocaffeic acid; metabolic transformation;
   metabolites; obesity; metabolic syndrome; oxidative stress-related
   disorders
ID WHITE ADIPOCYTES; PPAR-ALPHA; ACTIVATION; STRATEGIES; OBESITY; STRESS
AB This study investigates the bioactivity retention of chlorogenic acid (CGA) and its metabolite dihydrocaffeic acid (DHCA) by comparing their antioxidant, anti-inflammatory, and anti-obesogenic properties in vitro. CGA, found in coffee, fruits, and vegetables, is metabolized into DHCA, potentially enhancing bioactivity. Antioxidant capacity was assessed in Caco-2 cells, with DHCA showing superior activity at lower concentrations than CGA. Anti-inflammatory effects were evaluated in LPS-stimulated RAW 264.7 cells, where DHCA exhibited significant dose-dependent inhibition of nitrite production, surpassing CGA. Anti-obesogenic potential was analyzed in 3T3-L1 cells, with DHCA demonstrating stronger inhibition of adipogenesis and notable downregulation of adipogenic genes like PPAR gamma and C/EBP alpha. These results suggest that DHCA's enhanced therapeutic potential due to its simplified structure and increased bioavailability. This study highlights the importance of metabolic transformations in dietary polyphenols for chronic disease prevention and management.
C1 [Reza-Zaldivar, Edwin Estefan; Jacobo-Velazquez, Daniel A.] Tecnol Monterrey, Escuela Ingn & Ciencias, Campus Guadalajara,Ave Gen Ramon Corona 2514, Zapopan 45201, Jalisco, Mexico.
C3 Tecnologico de Monterrey
RP Jacobo-Velázquez, DA (corresponding author), Tecnol Monterrey, Escuela Ingn & Ciencias, Campus Guadalajara,Ave Gen Ramon Corona 2514, Zapopan 45201, Jalisco, Mexico.
RI Jacobo-Velázquez, Daniel/AAG-5973-2020; Jacobo-Velazquez, Daniel
   Alberto/E-4225-2013
OI Jacobo-Velazquez, Daniel Alberto/0000-0002-9478-2570
FU Tecnologico de Monterrey-The Institute for Obesity Research
FX Financial support for this study was provided by Tecnologico de
   Monterrey-The Institute for Obesity Research.
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Z9 1
U1 4
U2 12
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1947-6337
EI 1947-6345
J9 CYTA-J FOOD
JI CyTA-J. Food
PD DEC 31
PY 2024
VL 22
IS 1
AR 2390997
DI 10.1080/19476337.2024.2390997
PG 9
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA D1P2K
UT WOS:001293969100001
OA gold
DA 2025-06-11
ER

PT J
AU Giannopoulos, CK
   Tzima, IG
   Tentolouris, NK
   Vasileiadis, IA
AF Giannopoulos, Charalampos K.
   Tzima, Ioanna G.
   Tentolouris, Nikolaos K.
   Vasileiadis, Ioannis A.
TI Common Pathogenetic Pathways of Non-Alcoholic Fatty Liver Disease and
   Type 2 Diabetes Mellitus
SO CURRENT DIABETES REVIEWS
LA English
DT Review
DE Non-alcoholic fatty liver disease; diabetes mellitus type 2; hepatic de
   novo lipogenesis; immune regulatory mechanisms; genetics; pathogenesis
ID ENDOPLASMIC-RETICULUM STRESS; DE-NOVO LIPOGENESIS; NLRP3 INFLAMMASOME
   ACTIVATION; LACTOBACILLUS-CASEI CCFM419; REVERSES INSULIN-RESISTANCE;
   MODEST ALCOHOL-CONSUMPTION; SUPEROXIDE-DISMUTASE GENE; GROWTH-FACTOR
   EXPRESSION; NECROSIS-FACTOR-ALPHA; TRANSFER PROTEIN GENE
AB Type 2 diabetes mellitus (T2DM) and non-alcoholic fatty liver disease (NAFLD) are two cardinal manifestations of the metabolic syndrome, which is becoming a growing global pandemic and a health care burden. They constitute a pathogenetic duo, with complex interplay through interrelated, but still partly understood, pathophysiological pathways, which mainly involve lipid toxicity (expressed through increased hepatic de novo lipogenesis, hepatic and peripheral insulin resistance, upregulated lipolysis, lipoprotein abnormalities, hyperinsulinemia), impaired autophagy, mitochondrial dysfunction, endoplasmic reticulum stress, adipose tissue dysfunction with a consequent latent inflammatory state, inflammasome activation, genetic and epigenetic factors, altered gut microbiota and finally dietary factors. In this review, based on data from recent studies and focusing mainly on common molecular mechanisms, we will highlight the common pathophysiological grounds and the interplay between NAFLD and T2DM.
C1 [Giannopoulos, Charalampos K.; Vasileiadis, Ioannis A.] Natl & Kapodistrian Univ Athens, Evangelismos Hosp, Sch Med, Crit Care Dept 1, Athens, Greece.
   [Tzima, Ioanna G.] Natl & Kapodistrian Univ Athens, Sotiria Hosp, Sch Med, Dept Cardiol 3, Athens, Greece.
   [Tentolouris, Nikolaos K.] Natl & Kapodistrian Univ Athens, Laiko Gen Hosp, Sch Med, Dept Propaedeut & Internal Med 1, Athens, Greece.
C3 Evangelismos Hospital; National & Kapodistrian University of Athens;
   Athens Medical School; National & Kapodistrian University of Athens;
   Athens Medical School; National & Kapodistrian University of Athens;
   Athens Medical School; Laiko General Hospital
RP Vasileiadis, IA (corresponding author), Natl & Kapodistrian Univ Athens, Evangelismos Hosp, Sch Med, Crit Care Dept 1, Athens, Greece.
EM ioannisvmed@yahoo.gr
FU Declared none.
FX Declared none.
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PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1573-3998
EI 1875-6417
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JI Curr. Diabetes Reviews
PY 2023
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WC Endocrinology & Metabolism
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DA 2025-06-11
ER

PT J
AU Jong, CJ
   Sandal, P
   Schaffer, SW
AF Jong, Chian Ju
   Sandal, Priyanka
   Schaffer, Stephen W.
TI The Role of Taurine in Mitochondria Health: More Than Just an
   Antioxidant
SO MOLECULES
LA English
DT Review
DE taurine; mitochondria; antioxidant; 5-taurinomethyluridine; oxidative
   stress; apoptosis
ID CONGESTIVE-HEART-FAILURE; WOBBLE MODIFICATION DEFICIENCY;
   ELECTRON-TRANSPORT-CHAIN; STROKE-LIKE EPISODES; OXIDATIVE STRESS;
   DOUBLE-BLIND; LIPID-PEROXIDATION; TRANSFER-RNA; BETA-ALANINE; ORAL
   TAURINE
AB Taurine is a naturally occurring sulfur-containing amino acid that is found abundantly in excitatory tissues, such as the heart, brain, retina and skeletal muscles. Taurine was first isolated in the 1800s, but not much was known about this molecule until the 1990s. In 1985, taurine was first approved as the treatment among heart failure patients in Japan. Accumulating studies have shown that taurine supplementation also protects against pathologies associated with mitochondrial defects, such as aging, mitochondrial diseases, metabolic syndrome, cancer, cardiovascular diseases and neurological disorders. In this review, we will provide a general overview on the mitochondria biology and the consequence of mitochondrial defects in pathologies. Then, we will discuss the antioxidant action of taurine, particularly in relation to the maintenance of mitochondria function. We will also describe several reported studies on the current use of taurine supplementation in several mitochondria-associated pathologies in humans.
C1 [Jong, Chian Ju; Sandal, Priyanka] Univ Iowa, Carver Coll Med, Neurosci & Pharmacol, Iowa City, IA 52242 USA.
   [Schaffer, Stephen W.] Univ S Alabama, Coll Med, Dept Pharmacol, Mobile, AL 36688 USA.
C3 University of Iowa; University of South Alabama
RP Jong, CJ (corresponding author), Univ Iowa, Carver Coll Med, Neurosci & Pharmacol, Iowa City, IA 52242 USA.
EM chianju-jong@uiowa.edu; priyanka-sandal@uiowa.edu;
   sschaffe@southalabama.edu
RI Sandal, Priyanka/AAX-2229-2020
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NR 250
TC 111
Z9 117
U1 10
U2 100
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1420-3049
J9 MOLECULES
JI Molecules
PD AUG
PY 2021
VL 26
IS 16
AR 4913
DI 10.3390/molecules26164913
PG 21
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA UH6CP
UT WOS:000690016700001
PM 34443494
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Navarro-Alarcon, M
   Villalón, M
   Jiménez, C
   Quesada-Granados, J
   Agil, A
AF Navarro-Alarcon, Miguel
   Villalon, Marina
   Jimenez, Cecilia
   Quesada-Granados, Javier
   Agil, Ahmad
TI Melatonin increases magnesium concentrations in white adipose tissue and
   pancreas of diabetic obese rats
SO JOURNAL OF FUNCTIONAL FOODS
LA English
DT Article
DE Melatonin; Magnesium; Diabetic obese rats; White adipose tissue and
   organs
ID TYROSINE-KINASE-ACTIVITY; FATTY RATS; INSULIN-RESISTANCE; METABOLIC
   SYNDROME; INTRACELLULAR MAGNESIUM; GLUCOSE-HOMEOSTASIS; ADIPONECTIN
   RATIO; OXIDATIVE STRESS; PLASMA LEPTIN; BODY-WEIGHT
AB Melatonin is a natural bioactive compound, whose intake by obese diabetic Zucker (ZDF) rats improves this pathology. Hypomagnesaemia has also been observed in diabetes, and magnesium (Mg) is known to play an essential role in carbohydrate metabolism. In this study we have determined the effect of melatonin intake on Mg concentrations in white adipose tissues and organs in ZDF rats. This study reveals for the first time that melatonin intake increases Mg concentrations in subcutaneous lumbar, visceral, omentum, and gonadal adipose tissue and in the pancreas. These findings may be related to an improvement in the homeostatic regulation of adipocytokines produced by white adipose tissues, and to a reduction in plasmatic oxidative stress, which would lead to a decrease in insulin resistance and improvement in glucose homeostasis. These results open up the beneficial use of melatonin for the development of functional foods to ameliorate glucose homeostasis in obesity associated diabetes.
C1 [Navarro-Alarcon, Miguel; Villalon, Marina; Quesada-Granados, Javier] Univ Granada, Sch Pharm, Dept Nutr & Food Sci, Granada, Spain.
   [Jimenez, Cecilia; Agil, Ahmad] Univ Granada, Sch Med, Dept Pharmacol, Granada, Spain.
   [Jimenez, Cecilia; Agil, Ahmad] Univ Granada, Sch Med, Neurosci Inst CIBM, Granada, Spain.
C3 University of Granada; University of Granada; University of Granada
RP Navarro-Alarcon, M (corresponding author), Univ Granada, Sch Pharm, Dept Nutr & Food Sci, Granada, Spain.; Agil, A (corresponding author), Univ Granada, Sch Med, Dept Pharmacol, Granada, Spain.; Agil, A (corresponding author), Univ Granada, Sch Med, Neurosci Inst CIBM, Granada, Spain.
EM nalarcon@ugr.es; aagil@ugr.es
RI Navarro-Alarcon, Miguel/Q-4368-2019; Agil, Ahmad/D-9620-2014;
   Navarro-Alarcon, Miguel/K-6646-2014
OI Agil, Ahmad/0000-0003-0164-9648; Navarro-Alarcon,
   Miguel/0000-0002-3189-3310
FU Spanish Ministry of Economy and Competitiveness (Ministerio de Economia
   y Competitividad) [SAF 2013-45752-R]; CTS-109 group from the Junta de
   Andalucia (Spain); United Arab Emirates University (UAEU) College of
   Medicine and Health Sciences [FMHS/AA/Sd/26/13]
FX The study was supported by project SAF 2013-45752-R from the Spanish
   Ministry of Economy and Competitiveness (Ministerio de Economia y
   Competitividad), and by the CTS-109 group from the Junta de Andalucia
   (Spain) and project FMHS/AA/Sd/26/13 from the United Arab Emirates
   University (UAEU) College of Medicine and Health Sciences. The authors
   thank Richard Davies for editorial assistance.
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NR 67
TC 2
Z9 2
U1 0
U2 9
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1756-4646
J9 J FUNCT FOODS
JI J. Funct. Food.
PD SEP
PY 2018
VL 48
BP 167
EP 172
DI 10.1016/j.jff.2018.07.018
PG 6
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA GX2TS
UT WOS:000447573600018
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Menichini, F
   Tundis, R
   Loizzo, MR
   Bonesi, M
   D'Angelo, D
   Lombardi, P
   Mastellone, V
AF Menichini, Francesco
   Tundis, Rosa
   Loizzo, Monica R.
   Bonesi, Marco
   D'Angelo, Danila
   Lombardi, Pietro
   Mastellone, Vincenzo
TI Citrus medica L. cv Diamante (Rutaceae) peel extract improves
   glycaemic status of Zucker diabetic fatty (ZDF) rats and protects
   against oxidative stress
SO JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
LA English
DT Article
DE Antioxidant effects; Citrus medica L. cv Diamante; hypoglycaemic;
   hypolipidaemic; in vivo studies
ID GLUCOSE-HOMEOSTASIS; FLAVONOID APIGENIN; METABOLIC SYNDROME;
   LIPID-METABOLISM; ACYL-COA; ANTIOXIDANT; PLASMA; CHOLESTEROL;
   INHIBITION; NARINGENIN
AB This study aimed to investigate the antidiabetic, antilipidaemic and antioxidant activities of Citrus medica cv Diamante (Rutaceae) hydroalcoholic (CD) peel extract in Zucker diabetic fatty (ZDF) rats. The ability of CD to protect against oxidative stress was investigated by using different in vitro assays and in vivo by using the reactive oxygen metabolites-derived compounds (d-ROMs) test and the biological antioxidant potential test (BAP). Two different doses of CD extract (300 and 600 mg/kg/die) were administered at ZDF rats for 4 weeks. CD reduced cholesterol and triglycerides levels. A dose-dependent effect on body weight and serum glucose levels was observed. A decrease of d-ROMs and an increase of BAP were recorded by using the dose of 600 mg/kg. The extract inhibited lipid peroxidation (IC50 value of 0.23 mg/ml). These findings suggest as an efficient phytotherapeutic approach in combating hyperlipidaemic and hyperglycaemic disorders.
C1 [Menichini, Francesco; Tundis, Rosa; Loizzo, Monica R.; Bonesi, Marco] Univ Calabria, Dept Pharm Hlth & Nutr Sci, I-87036 Arcavacata Di Rende, Italy.
   [D'Angelo, Danila; Lombardi, Pietro; Mastellone, Vincenzo] Univ Naples Federico II, Dept Vet Med & Anim Prod, Naples, Italy.
C3 University of Calabria; University of Naples Federico II
RP Bonesi, M (corresponding author), Univ Calabria, Dept Pharm Hlth & Nutr Sci, I-87036 Arcavacata Di Rende, Italy.
EM marco.bonesi@unical.it
RI Lombardi, Pietro/GVU-0505-2022; dangelo, Danila/GVR-7576-2022
OI BONESI, Marco/0000-0001-8003-3846; LOMBARDI, Pietro/0000-0001-7876-8800;
   d'ANGELO, Danila/0000-0003-2903-4039
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NR 37
TC 21
Z9 21
U1 2
U2 10
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1475-6366
EI 1475-6374
J9 J ENZYM INHIB MED CH
JI J. Enzym. Inhib. Med. Chem.
PY 2016
VL 31
IS 6
BP 1270
EP 1276
DI 10.3109/14756366.2015.1115400
PG 7
WC Biochemistry & Molecular Biology; Chemistry, Medicinal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
GA DY6WR
UT WOS:000385270300052
PM 26643200
OA Bronze, Green Submitted
DA 2025-06-11
ER

PT J
AU Puri, S
   Mandal, SK
   Joshi, T
   Nikita
   Srivastava, A
   Sharma, PK
   Deepa, PR
AF Puri, Sonakshi
   Mandal, Sumit Kumar
   Joshi, Tripti
   Nikita
   Srivastava, Ayush
   Sharma, Pankaj Kumar
   Deepa, P. R.
TI Anti-adipogenic and anti-steatotic potential of edible pigment bixin and
   annatto seed extracts: LC-MS based bioactive profiling and in
   vitro biochemical validation
SO FOOD BIOSCIENCE
LA English
DT Article
DE Bixin; Annatto; NAFLD; Obesity; Oxidative stress; Metabolic syndrome
ID DIET-INDUCED OBESITY; INDUCED FATTY LIVER; ADIPOSE-TISSUE; MITOCHONDRIAL
   DYSFUNCTION; LIPID-METABOLISM; ORELLANA L.; PATHOGENESIS; INFLAMMATION;
   CAROTENOIDS; DISEASE
AB The rising prevalence of metabolic syndrome (MetS), such as obesity and its hepatic complication, and nonalcoholic fatty liver disease (NAFLD), necessitates safe, effective, and protective interventions. Natural products, such as carotenoids, including bixin derived from annatto seeds, have emerged as promising candidates due to their multifaceted pharmacological properties. This study aimed to characterize the edible food pigment bixin and other co-existing bioactives in acetone- and ethyl lactate-extracts of Bixa Orellana L. seeds, followed by their anti-adipogenic and anti-steatotic assessments using in-vitro models of obesity and NAFLD. LC-MS analysis revealed the presence of various phytochemicals in the bixin rich solvent extracts. In vitro studies demonstrated differential and significant anti-adipogenic and anti-steatotic effects of bixin (pure pigment) and solvent extracts of annatto seeds (P < 0.05). The LC-MS profiling of annatto seed extracts revealed the presence of bixin and several bixinoids. Other key phytochemicals that were identified were eicosatrienoic acid, geranylgeraniol, hypolatein, delta-tocotrienol, caffeoyl acid derivative, and zeaxanthin, which were differentially abundant in each solvent extract. Bixin and coexisting bioactives in the annatto seed extracts demonstrated significant antioxidant, anti-inflammatory, and anti-lipidemic effects (P < 0.05) in the present in vitro MetS models. Further studies may be directed toward evaluating the nutraceutical potential of bixin in combination with the implicated phytochemicals in the extracts for treating metabolic disorders.
C1 [Puri, Sonakshi; Mandal, Sumit Kumar; Joshi, Tripti; Nikita; Srivastava, Ayush; Sharma, Pankaj Kumar; Deepa, P. R.] Birla Inst Technol & Sci Pilani, Dept Biol Sci, Biochem & Enzyme Biotechnol Lab, Pilani Campus, Pilani 333031, Rajasthan, India.
C3 Birla Institute of Technology & Science Pilani (BITS Pilani)
RP Deepa, PR (corresponding author), Birla Inst Technol & Sci Pilani, Dept Biol Sci, Pilani Campus, Pilani 333031, Rajasthan, India.
EM deepa@pilani.bits-pilani.ac.in
RI Joshi, Tripti/KSM-8318-2024
FU Indian Council of Medical Research (ICMR) , New Delhi
   [52/13/2022-BIO/BMS]
FX <B>Funding</B> This work was supported by a research grant from the
   Indian Council of Medical Research (ICMR) , New Delhi (Grant No.
   52/13/2022-BIO/BMS) .
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PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2212-4292
EI 2212-4306
J9 FOOD BIOSCI
JI Food Biosci.
PD FEB
PY 2025
VL 64
AR 105893
DI 10.1016/j.fbio.2025.105893
EA JAN 2025
PG 12
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA W8O1L
UT WOS:001421088200001
DA 2025-06-11
ER

PT J
AU Pittala, V
   Vanella, L
   Salerno, L
   Romeo, G
   Marrazzo, A
   Di Giacomo, C
   Sorrenti, V
AF Pittala, Valeria
   Vanella, Luca
   Salerno, Loredana
   Romeo, Giuseppe
   Marrazzo, Agostino
   Di Giacomo, Claudia
   Sorrenti, Valeria
TI Effects of Polyphenolic Derivatives on Heme Oxygenase-System in
   Metabolic Dysfunctions
SO CURRENT MEDICINAL CHEMISTRY
LA English
DT Review
DE Polyphenols; oxidative stress; diabetes; NASH; NAFLD; metabolic
   syndrome; Nrf2; HO-1
ID ACID PHENETHYL ESTER; NF-KAPPA-B; INDUCED ENDOTHELIAL DYSFUNCTION;
   IMPROVES INSULIN SENSITIVITY; PURIFIED SOY ISOFLAVONES; HIGH-FAT DIET;
   OXIDATIVE STRESS; CAFFEIC ACID; CARBON-MONOXIDE; NITRIC-OXIDE
AB Background: The aim of this review is to summarize the effects of various naturally occurring polyphenols in the management of metabolic dysfunctions. This cluster of metabolic abnormalities comprises insulin resistance, increased levels of free fatty acids, hyper-cholesterolemia, obesity, hyperglycemia and hypertension, diabetes mellitus (DM) type 1 (T1DM) and type 2 (T2DM) along with DM-induced complications. Most of them are included in the well-known metabolic syndrome (MS). These metabolic dysfunctions in turn are tightly associated to a high risk of development of cardiovascular diseases. Although molecular mechanisms underlying the onset of metabolic dysfunctions and related complications are not yet clear, it is widely recognized that they are associated to oxidative stress and chronic low-grade of inflammatory levels.
   Methods: We undertook a structured search of bibliographic references through the use of SciFinder. The database was provided by a division of ACS (American Chemical Society) and guarantees access to the world's most extensive and authoritative source of references. The search was performed using "heme oxygenase-1" as research topic and a subsequent refinement was done by using inclusion/exclusion criteria. The quality of retrieved papers was evaluated on the basis of standard tools.
   Results: From a careful review of the selected literature, of interest, the use of natural antioxidant polyphenols seems to be the ideal pharmacological treatment since they are endowed with strong antioxidant and anti-inflammatory properties. In particular, some polyphenols such as curcumin, quercetin, genistein, and caffeic acid phenethyl ester are able to potently activate nuclear factor erythroid 2-related factor 2 (Nrf2) and related downstream expression of enzymes such as heme oxygenase-1 (HO-1). Indeed, an overexpression of HO-1 has been demonstrated to play a beneficial role in metabolic diseases.
   Conclusion: The following review is intended to stimulate interest in the role of natural occurring HO-1 inducers in metabolic dysfunction, focusing on the clinical potential of HO-1 activity to restore the balance between pro-oxidant and anti-oxidants systems.
C1 [Pittala, Valeria; Salerno, Loredana; Romeo, Giuseppe; Marrazzo, Agostino] Univ Catania, Dept Drug Sci, Sect Med Chem, Viale A Doria 6, I-95125 Catania, Italy.
   [Vanella, Luca; Di Giacomo, Claudia; Sorrenti, Valeria] Univ Catania, Dept Drug Sci, Sect Biochem, Viale A Doria 6, I-95125 Catania, Italy.
C3 University of Catania; University of Catania
RP Pittala, V (corresponding author), Univ Catania, Dept Drug Sci, Catania, Italy.
EM vpittala@unict.it
RI Romeo, Giuseppe/AAG-7086-2019; Vanella, Luca/J-7354-2016
OI Di Giacomo, Claudia/0000-0002-2665-0007; Pittala,
   Valeria/0000-0003-1856-0308
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NR 139
TC 41
Z9 42
U1 3
U2 16
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 0929-8673
EI 1875-533X
J9 CURR MED CHEM
JI Curr. Med. Chem.
PY 2018
VL 25
IS 13
BP 1577
EP 1595
DI 10.2174/0929867324666170616110748
PG 19
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Pharmacology &
   Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
GA GF8SV
UT WOS:000432244300010
PM 28618991
DA 2025-06-11
ER

PT J
AU Moroni-González, D
   Sarmiento-Ortega, VE
   Diaz, A
   Brambila, E
   Treviño, S
AF Moroni-Gonzalez, Diana
   Sarmiento-Ortega, Victor Enrique
   Diaz, Alfonso
   Brambila, Eduardo
   Trevino, Samuel
TI Pancreas-Liver-Adipose Axis: Target of Environmental Cadmium Exposure
   Linked to Metabolic Diseases
SO TOXICS
LA English
DT Review
DE cadmium; pancreas; liver; adipose tissue; metabolic diseases
ID BETA-CELL DYSFUNCTION; INDUCED OXIDATIVE STRESS; METALLOTHIONEIN
   GENE-EXPRESSION; ANTIOXIDANT ENZYMES ACTIVITY; INDUCED
   INSULIN-RESISTANCE; PROTEIN-KINASE-C; NF-KAPPA-B; LIPID-PEROXIDATION;
   NADPH OXIDASE; GLUTATHIONE-PEROXIDASE
AB Cadmium has been well recognized as a critical toxic agent in acute and chronic poisoning cases in occupational and nonoccupational settings and environmental exposure situations. Cadmium is released into the environment after natural and anthropogenic activities, particularly in contaminated and industrial areas, causing food pollution. In the body, cadmium has no biological activity, but it accumulates primarily in the liver and kidney, which are considered the main targets of its toxicity, through oxidative stress and inflammation. However, in the last few years, this metal has been linked to metabolic diseases. The pancreas-liver-adipose axis is largely affected by cadmium accumulation. Therefore, this review aims to collect bibliographic information that establishes the basis for understanding the molecular and cellular mechanisms linked to cadmium with carbohydrate, lipids, and endocrine impairments that contribute to developing insulin resistance, metabolic syndrome, prediabetes, and diabetes.
C1 [Moroni-Gonzalez, Diana; Sarmiento-Ortega, Victor Enrique; Brambila, Eduardo; Trevino, Samuel] Meritorious Autonomous Univ Puebla, Fac Chem Sci, Dept Clin Chem, Lab Chem Clin Invest, Ciudad Univ, Puebla 72560, Mexico.
   [Diaz, Alfonso] Meritorious Autonomous Univ Puebla, Fac Chem Sci, Dept Pharm, 22 South FCQ9,Ciudad Univ, Puebla 72560, Mexico.
RP Treviño, S (corresponding author), Meritorious Autonomous Univ Puebla, Fac Chem Sci, Dept Clin Chem, Lab Chem Clin Invest, Ciudad Univ, Puebla 72560, Mexico.
OI Trevino, Samuel/0000-0001-5679-1671; Moroni Gonzalez,
   Diana/0000-0003-4500-0648; Diaz, Alfonso/0000-0003-4092-6636
FU Vicerrectoria de Investigacion y Posgrado [VIEP] [TRMS-NAT22-1];
   CONACyT; "Sistema Nacional de Investigadores" of Mexico [DMG] [758984];
   European Research Council (ERC) [758984] Funding Source: European
   Research Council (ERC)
FX Vicerrectoria de Investigacion y Posgrado [VIEP; TRMS-NAT22-1], CONACyT,
   and the "Sistema Nacional de Investigadores" of Mexico for the financial
   support of this research project [DMG, 758984].
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NR 285
TC 15
Z9 15
U1 1
U2 19
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2305-6304
J9 TOXICS
JI Toxics
PD MAR
PY 2023
VL 11
IS 3
AR 223
DI 10.3390/toxics11030223
PG 28
WC Environmental Sciences; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Toxicology
GA C1OZ1
UT WOS:000959708200001
PM 36976988
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Elibol, B
   Kilic, U
AF Elibol, Birsen
   Kilic, Ulkan
TI High Levels of SIRT1 Expression as a Protective Mechanism Against
   Disease-Related Conditions
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Review
DE SIRT1 expression; oxidative stress; metabolic diseases; cardiovascular
   diseases; neurodegenerative diseases
ID NF-KAPPA-B; CORONARY-ARTERY-DISEASE; EXTENDS LIFE-SPAN; CALORIE
   RESTRICTION; ALZHEIMERS-DISEASE; OXIDATIVE STRESS; CELL-SURVIVAL;
   HEPATIC STEATOSIS; NEURONAL SIRT1; ADIPOSE-TISSUE
AB SIRT1 protein, a member of Silent Information Regulator 2 (Sir2) protein family, have gained considerable attention as epigenetic regulators for a great area in the human physiology. Changes in sirtuin expression are critical in several diseases, including metabolic syndrome, cardiovascular diseases, cancer and neurodegeneration. Here, we provide an overview of the association of the increasing level of SIRT1 protein for regulating some disease related conditions such as obesity, cardiovascular diseases and neurodegeneration. This review also provides a detailed molecular understanding of the interaction of the some basic molecules with increasing SIRT1 levels rather than reduction of the SIRT1 expression. In this context, the current approaches to enhancing the expression of SIRT1 points the importance of epigenetics in several age-related diseases to provide a healthy aging by developing novel therapies which can prevent or damp the progression of some diseases.
C1 [Elibol, Birsen] Bezmialem Vakif Univ, Dept Med Biol, Fac Med, Istanbul, Turkey.
   [Kilic, Ulkan] Univ Hlth Sci, Dept Med Biol, Fac Med, Istanbul, Turkey.
C3 Bezmialem Vakif University; University of Health Sciences Turkey
RP Kilic, U (corresponding author), Univ Hlth Sci, Dept Med Biol, Fac Med, Istanbul, Turkey.
EM uckilic@yahoo.com
RI Elibol, Birsen/C-8369-2018
OI Elibol, Birsen/0000-0002-9462-0862
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NR 102
TC 122
Z9 125
U1 1
U2 11
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD OCT 15
PY 2018
VL 9
AR 614
DI 10.3389/fendo.2018.00614
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA GW9AI
UT WOS:000447273000001
PM 30374331
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Vecera, R
   Zacharova, A
   Kazdova, L
   Matuskova, Z
   Skottova, N
   Strojil, J
   Oliyarnyk, O
   Anzenbacher, P
AF Vecera, Rostislav
   Zacharova, Alice
   Kazdova, Ludmila
   Matuskova, Zuzana
   Skottova, Nina
   Strojil, Jan
   Oliyarnyk, Olena
   Anzenbacher, Pavel
TI Silybin affects the liver microsomal CYP2C6 in HHTg rats
SO BIOMEDICAL PAPERS-OLOMOUC
LA English
DT Article
DE silybin; cytochrome P450; CYP2C6; hereditary hypertriglyceridemic rat;
   liver steatosis
ID HEREDITARY HYPERTRIGLYCERIDEMIC RATS; OXIDATIVE STRESS; WISTAR RATS;
   EXPRESSION; ANTIOXIDANT; SILYMARIN; CHOLESTEROL; SILIBININ; CELLS; MODEL
AB Aim. This study aims to investigate the effect of silybin on liver expression and activity of rat CYP2C6 under mild liver steatosis. This cytochrome P450 enzyme is considered to be a counterpart of human CYP2C9, which metabolizes commonly prescribed drugs, such as ibuprofen, diclofenac, or warfarin.
   Methods. Male hereditary hypertriglyceridemic rats (accepted model of metabolic syndrome) were fed: 1) standard laboratory diet (STD), 2) high cholesterol diet (HCD = STD + 1% of cholesterol w/w + 10% of lard fat w/w), 3) high cholesterol diet with silybin (0.5% w/w) for 21 days. Expression of cytochrome P450 2C6 was measured in liver using real-time PCR (at mRNA level) and Western blotting (at protein level). Formation of diclofenac metabolite (typical marker substrate of CYP2C6 enzyme activity) was analyzed using HPLC with UV detection.
   Results. Silybin in hereditary hypertriglyceridemic rats on HCD diet significantly increased activity of CYP2C6 and its expression on mRNA level. Expression of CYP2C6 on protein level was non-significantly affected by silybin consumption. Our results suggest that CYP2C6 is up-regulated by silybin in hereditary hypertriglyceridemic rats on high cholesterol diet.
   Conclusion. Since cytochrome P450 2C6 is considered to be a counterpart of human CYP2C9, the results obtained open the possibility that in human silybin may affect the metabolism of drugs metabolized by this cytochrome P450. Further studies are needed to elucidate the effects of silybin on CYP2C9 in humans suffering from metabolic syndrome.
C1 [Vecera, Rostislav; Zacharova, Alice; Matuskova, Zuzana; Skottova, Nina; Strojil, Jan; Anzenbacher, Pavel] Palacky Univ Olomouc, Fac Med & Dent, Dept Pharmacol, Olomouc, Czech Republic.
   [Kazdova, Ludmila; Oliyarnyk, Olena] Inst Clin & Expt Med, Ctr Med Expt, Prague, Czech Republic.
C3 Palacky University Olomouc; Institute for Clinical & Experimental
   Medicine (IKEM)
RP Vecera, R (corresponding author), Palacky Univ Olomouc, Fac Med & Dent, Dept Pharmacol, Olomouc, Czech Republic.
EM vecera@seznam.cz
RI Oliyarnyk, Olena/Q-6380-2019
FU Czech Science Foundation [13-10813S]
FX This work was supported by Czech Science Foundation project 13-10813S.
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SN 1213-8118
J9 BIOMED PAP
JI Biomed. Pap-Olomouc
PY 2013
VL 157
SU 1
BP S60
EP S64
PG 5
WC Engineering, Biomedical; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering; Research & Experimental Medicine
GA 222KB
UT WOS:000324728600004
DA 2025-06-11
ER

PT J
AU Xiong, W
   Meng, XF
   Zhang, C
AF Xiong, Wei
   Meng, Xian-Fang
   Zhang, Chun
TI NLRP3 Inflammasome in Metabolic-Associated Kidney Diseases: An Update
SO FRONTIERS IN IMMUNOLOGY
LA English
DT Review
DE NLRP3; inflammasome; kidney diseases; metabolic syndrome; innate
   immunity
ID ALLEVIATES HIGH GLUCOSE; DIABETIC-NEPHROPATHY; OXIDATIVE STRESS;
   PODOCYTE INJURY; GLOMERULAR SCLEROSIS; URIC-ACID; ACTIVATION; RECEPTOR;
   MECHANISMS; OBESITY
AB Metabolic syndrome (MS) is a group of complex metabolic disorders syndrome, which refers to the pathological state of metabolism disorder of protein, fat, carbohydrate and other substances in human body. The kidney is an important organ of metabolism, and various metabolic disorders can lead to the abnormalities in the structure and function of the kidney. The recognition of pathogenesis and treatment measures of renal damage in MS is a very important part for the renal function preserve. Inflammatory response caused by various metabolic factors is a protective mechanism of the body, but persistent inflammation will become a harmful factor and aggravate kidney damage. Inflammasomes are sensors of the innate immune system that play crucial roles in initiating inflammation in response to acute infections and chronic diseases. They are multiprotein complex composed of cytoplasmic sensors (mainly NLR family members), apoptosis-associated speck-like protein (ASC or PYCARD) and pro-caspase-1. After receiving exogenous and endogenous stimuli, the sensors begin to assemble inflammasome and then promote the release of inflammatory cytokines IL-1 beta and IL-18, resulting in a special way of cell death named pyroptosis. In the kidney, NLRP3 inflammasome can be activated by a variety of pathways, which eventually leads to inflammatory infiltration, renal intrinsic cell damage and renal function decline. This paper reviews the function and specific regulatory mechanism of inflammasome in kidney damage caused by various metabolic disorders, which will provide a new therapeutic perspective and targets for kidney diseases.
C1 [Xiong, Wei; Zhang, Chun] Huazhong Univ Sci & Technol, Tongji Med Coll, Union Hosp, Dept Nephrol, Wuhan, Peoples R China.
   [Meng, Xian-Fang] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Basic Med Sci, Dept Neurobiol, Wuhan, Peoples R China.
C3 Huazhong University of Science & Technology; Huazhong University of
   Science & Technology
RP Zhang, C (corresponding author), Huazhong Univ Sci & Technol, Tongji Med Coll, Union Hosp, Dept Nephrol, Wuhan, Peoples R China.; Meng, XF (corresponding author), Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Basic Med Sci, Dept Neurobiol, Wuhan, Peoples R China.
EM xfmeng@mails.tjmu.edu.cn; drzhangchun@hust.edu.cn
RI ZHANG, CHUN/HLH-6523-2023; Xiong, Wei/HKV-1747-2023
OI Zhang, Chun/0000-0003-3565-8024
FU National Natural Science Foundation of China [81961138007, 81974096,
   81770711]; program for HUST Academic Frontier Youth Team [2017QYTD20]
FX This work was supported by Grants from the National Natural Science
   Foundation of China (81961138007, 81974096, 81770711), and program for
   HUST Academic Frontier Youth Team (2017QYTD20).
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NR 83
TC 29
Z9 36
U1 0
U2 17
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-3224
J9 FRONT IMMUNOL
JI Front. Immunol.
PD JUL 8
PY 2021
VL 12
AR 714340
DI 10.3389/fimmu.2021.714340
PG 9
WC Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology
GA TM4YI
UT WOS:000675556100001
PM 34305953
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Junková, K
   Mirchi, LF
   Chylíková, B
   Janku, M
   Silhavy, J
   Hüttl, M
   Marková, I
   Miklánková, D
   Vcelák, J
   Malínská, H
   Pravenec, M
   Seda, O
   Liska, F
AF Junkova, Kristyna
   Mirchi, Lukas F.
   Chylikova, Blanka
   Janku, Michaela
   Silhavy, Jan
   Huttl, Martina
   Markova, Irena
   Miklankova, Denisa
   Vcelak, Josef
   Malinska, Hana
   Pravenec, Michal
   Seda, Ondrej
   Liska, Frantisek
TI Hepatic Transcriptome Profiling Reveals Lack of Acsm3 Expression
   in Polydactylous Rats with High-Fat Diet-Induced Hypertriglyceridemia
   and Visceral Fat Accumulation
SO NUTRIENTS
LA English
DT Article
DE metabolic syndrome; high-fat diet; insulin resistance;
   hypertriglyceridemia; polydactylous rat; spontaneously hypertensive rat;
   liver transcriptome; Acsm3
ID COA SYNTHETASE GENE; INSULIN-RESISTANCE; SA GENE; HYPERTENSION;
   IDENTIFICATION; ASSOCIATION; CAUCASIANS; OBESITY; TISSUE; ACIDS
AB Metabolic syndrome (MetS) is an important cause of worldwide morbidity and mortality. Its complex pathogenesis includes, on the one hand, sedentary lifestyle and high caloric intake, and, on the other hand, there is a clear genetic predisposition. PD (Polydactylous rat) is an animal model of hypertriglyceridemia, insulin resistance, and obesity. To unravel the genetic and pathophysiologic background of this phenotype, we compared morphometric and metabolic parameters as well as liver transcriptomes among PD, spontaneously hypertensive rat, and Brown Norway (BN) strains fed a high-fat diet (HFD). After 4 weeks of HFD, PD rats displayed marked hypertriglyceridemia but without the expected hepatic steatosis. Moreover, the PD strain showed significant weight gain, including increased weight of retroperitoneal and epididymal fat pads, and impaired glucose tolerance. In the liver transcriptome, we found 5480 differentially expressed genes, which were enriched for pathways involved in fatty acid beta and omega oxidation, glucocorticoid metabolism, oxidative stress, complement activation, triacylglycerol and lipid droplets synthesis, focal adhesion, prostaglandin synthesis, interferon signaling, and tricarboxylic acid cycle pathways. Interestingly, the PD strain, contrary to SHR and BN rats, did not express the Acsm3 (acyl-CoA synthetase medium-chain family member 3) gene in the liver. Together, these results suggest disturbances in fatty acid utilization as a molecular mechanism predisposing PD rats to hypertriglyceridemia and fat accumulation.
C1 [Junkova, Kristyna; Mirchi, Lukas F.; Chylikova, Blanka; Janku, Michaela; Pravenec, Michal; Seda, Ondrej; Liska, Frantisek] Charles Univ Prague, Fac Med 1, Inst Biol & Med Genet, Prague 12800, Czech Republic.
   [Junkova, Kristyna; Mirchi, Lukas F.; Chylikova, Blanka; Janku, Michaela; Pravenec, Michal; Seda, Ondrej; Liska, Frantisek] Gen Univ Hosp, Prague 12800, Czech Republic.
   [Silhavy, Jan; Pravenec, Michal; Liska, Frantisek] Czech Acad Sci, Inst Physiol, Dept Genet Model Dis, Prague 14220, Czech Republic.
   [Huttl, Martina; Markova, Irena; Miklankova, Denisa; Malinska, Hana] Inst Clin & Expt Med, Prague 14021, Czech Republic.
   [Vcelak, Josef] Inst Endocrinol, Prague 11694, Czech Republic.
C3 Charles University Prague; General University Hospital Prague; Czech
   Academy of Sciences; Institute of Physiology of the Czech Academy of
   Sciences; Institute for Clinical & Experimental Medicine (IKEM);
   Institute of Endocrinology - Prague
RP Liska, F (corresponding author), Charles Univ Prague, Fac Med 1, Inst Biol & Med Genet, Prague 12800, Czech Republic.; Liska, F (corresponding author), Gen Univ Hosp, Prague 12800, Czech Republic.; Liska, F (corresponding author), Czech Acad Sci, Inst Physiol, Dept Genet Model Dis, Prague 14220, Czech Republic.
EM kristyna.junkova@lf1.cuni.cz; lfmirchi@gmail.com;
   blanka.chylikova@lf1.cuni.cz; jankum@centrum.cz; Jan.Silhavy@fgu.cas.cz;
   mabw@ikem.cz; irma@ikem.cz; mild@ikem.cz; jvcelak@endo.cz; haml@ikem.cz;
   michal.pravenec@fgu.cas.cz; ondrej.seda@lf1.cuni.cz;
   frantisek.liska@lf1.cuni.cz
RI Chylikova, Blanka/D-2976-2017; Silhavy, Jan/B-5292-2014; Janku,
   Michaela/L-8329-2017; Vcelak, Josef/MAH-6912-2025; Liska,
   Frantisek/N-9192-2017; Pravenec, Michal/B-1666-2012; Seda,
   Ondrej/A-2058-2008
OI Markova, Irena/0000-0002-4331-7636; Pravenec,
   Michal/0000-0001-9197-5871; Seda, Ondrej/0000-0001-8498-5895; Malinska,
   Hana/0000-0002-9076-3399
FU Charles University [36317]; Student Scientific Research (SVV) grant
   [260516]; Ministry of Health, Czech Republic-conceptual development of
   research organization, General University Hospital in Prague [64165]
FX Project was supported by Charles University grant No. 36317 and Student
   Scientific Research (SVV) grant No. 260516, and the Ministry of Health,
   Czech Republic-conceptual development of research organization 64165,
   General University Hospital in Prague.
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NR 42
TC 8
Z9 8
U1 0
U2 13
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD MAY
PY 2021
VL 13
IS 5
AR 1462
DI 10.3390/nu13051462
PG 15
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA ST4SH
UT WOS:000662434800001
PM 33923085
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Shaffer, EA
AF Shaffer, EA
TI Bariatric surgery - A promising solution for nonalcoholic
   steatohepatitis in the very obese
SO JOURNAL OF CLINICAL GASTROENTEROLOGY
LA English
DT Article; Proceedings Paper
CT Symposium on Nonalcoholic Fatty Liver Diseases and Nonalcoholic
   Steatohepatitis
CY 2004
CL New York, NY
DE nonalcoholic fatty liver disease; nonalcoholic steatohepatitis; weight
   loss; obesity; metabolic syndrome; bariatric surgery
ID VERTICAL BANDED GASTROPLASTY; MORBIDLY OBESE; GASTRIC BYPASS;
   SURGICAL-TREATMENT; UNITED-STATES; LIVER-INJURY; WEIGHT-LOSS;
   PREVALENCE; TRENDS; OVERWEIGHT
AB paucity of well-conducted studies that are of sufficient duration and quality to determine the outcome, which is best defined by liver biopsy. The mainstays, diet and physical activity plus behavioral modifications, are not always successful, particularly in the very obese. Although it is intuitive to expect that weight loss should diminish steatosis, only limited evidence exists that liver enzymes improve with reduction in body weight. The available pharmacologic therapy has focused on the two limbs of the pathogenetic basis for nonalcoholic steatohepatitis (NASH), insulin resistance and oxidative stress, but with quite limited success. Neither behavioral, nor dietary, nor drug therapy has been particularly effective either in obesity or NASH. In the severely obese, the fatty liver and its stages often have progressed to NASH or cirrhosis even before contemplating therapy. In the severely obese, the best therapeutic modality is bariatric surgery, which is safe and has been successful in producing a 61% weight loss overall. The result is improvement in diabetes mellitus, the metabolic syndrome, and presumably its sequelae. Early reports (and procedures) were attended with dramatic weight loss but markedly aggravated the inflammatory liver disease. In recent trials with more modest weight loss and less malnutrition, bariatric surgery reduced the fat, inflammation, and even the fibrosis in well-documented NASH. These promising procedures will undoubtedly increase and constitute the major therapeutic modality for those who are severely obese.
C1 Univ Calgary, Dept Med, Div Gastroenterol, Fac Med, Calgary, AB T2N 4N1, Canada.
C3 University of Calgary
RP Univ Calgary, Dept Med, Div Gastroenterol, Fac Med, 3350 Hosp Dr NW, Calgary, AB T2N 4N1, Canada.
EM shaffer@ucalgary.ca
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NR 58
TC 32
Z9 34
U1 0
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0192-0790
EI 1539-2031
J9 J CLIN GASTROENTEROL
JI J. Clin. Gastroenterol.
PD MAR
PY 2006
VL 40
IS 3
SU S
BP S44
EP S50
PG 7
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Gastroenterology & Hepatology
GA 034CR
UT WOS:000236902900009
DA 2025-06-11
ER

PT J
AU Entringer, S
   Kumsta, R
   Hellharnmer, DH
   Wadhwa, PD
   Wüst, S
AF Entringer, Sonja
   Kumsta, Robert
   Hellharnmer, Dirk H.
   Wadhwa, Pathik D.
   Wuest, Stefan
TI Prenatal exposure to maternal psychosocial stress and HPA axis
   regulation in young adults
SO HORMONES AND BEHAVIOR
LA English
DT Article
DE Prenatal stress; Psychosocial stress; Hypothalamus-pituitary-adrenal
   (HPA) axis; Trier Social Stress Test (TSST); ACTH(1-24) stimulation test
ID LOW-BIRTH-WEIGHT; PARENTAL BONDING INSTRUMENT; PITUITARY-ADRENAL AXIS;
   CORONARY HEART-DISEASE; CORTISOL CONCENTRATIONS; DEPRESSED OUTPATIENTS;
   ORAL-CONTRACEPTIVES; METABOLIC SYNDROME; DUTCH FAMINE; RESPONSES
AB Epidemiological studies have reported associations between measures of size and weight at birth and disease risk in later life. Alteration in the regulation of the hypothalamic-pituitary-ad renal (HPA) axis in response to prenatal stress has been proposed as one underlying mechanism. The present study investigated in humans the association of prenatal psychosocial stress exposure with subsequent HPA axis regulation in adult life, with a focus on measures of response to challenge and feedback sensitivity. Healthy young adults whose mothers experienced severe stress during their pregnancy in form of major negative life events (e.g. death of someone close; prenatal stress (PS) group, n=31) and an age-matched comparison group (CC, n=30) underwent the Trier Social Stress Test (TSST) and a 1 mu g ACTH(1-24) stimulation test. In addition, a diurnal cortisol profile was assessed. ACTH concentrations following a standardized behavioural challenge paradigm (TSST) were marginally significantly higher in PS subjects than in CC subjects (p=.06). Pre-TSST adrenocortical (cortisol) levels were lower (p=.007), whereas the increase in cortisol in response to the TSST was higher (p=.03) in PS subjects compared to CC subjects. Cortisol concentrations following a pharmacological stimulation test simulating pituitary activity (ACTH(1-24) test) were significantly lower in PS than in CG subjects (p=.006). No differences emerged between the two groups in basal diurnal cortisol levels. This study provides first evidence in humans of an association between prenatal psychosocial stress exposure and subsequent alterations in the regulation of the HPA axis. (C) 2008 Elsevier Inc. All rights reserved.
C1 [Wuest, Stefan] Cent Inst Mental Hlth, Dept Genet Epidemiol Psychiat, D-68159 Mannheim, Germany.
   [Entringer, Sonja; Kumsta, Robert; Hellharnmer, Dirk H.; Wuest, Stefan] Univ Trier, Dept Clin & Physiol Psychol, D-54290 Trier, Germany.
   [Entringer, Sonja; Wadhwa, Pathik D.] Univ Calif Irvine, Dept Psychiat & Human Behav, Irvine, CA 92697 USA.
   [Kumsta, Robert] Kings Coll London, Inst Psychiat, MRC Social Genet & Dev Psychiat Ctr, London SE5 9AF, England.
   [Kumsta, Robert] Univ Southampton, Sch Psychol, Southampton SO17 1BJ, Hants, England.
C3 Central Institute of Mental Health; Universitat Trier; University of
   California System; University of California Irvine; University of
   London; King's College London; University of Southampton
RP Wüst, S (corresponding author), Cent Inst Mental Hlth, Dept Genet Epidemiol Psychiat, J5, D-68159 Mannheim, Germany.
EM stefan.wuest@zi-mannheim.de
RI Entringer, Sonja/ABB-9405-2020; Hellhammer, Dirk/F-1888-2013; Kumsta,
   Robert/P-9641-2016
OI Wust, Stefan/0000-0002-2315-8949; Entringer, Sonja/0000-0002-9926-7076;
   Kumsta, Robert/0000-0001-6006-6958
FU German Research Foundation [WU 324/3-(1-3), GRK 1389/1]; US PHS (NIH)
   [HD-047609, HD-041696, HD-33506]
FX Supported by the German Research Foundation grants WU 324/3-(1-3), GRK
   1389/1 to SW and US PHS (NIH) grants HD-047609, HD-041696 and HD-33506
   to PDW.
CR [Anonymous], ENCY MENTAL HLTH
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NR 56
TC 186
Z9 214
U1 2
U2 29
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0018-506X
EI 1095-6867
J9 HORM BEHAV
JI Horm. Behav.
PD FEB
PY 2009
VL 55
IS 2
BP 292
EP 298
DI 10.1016/j.yhbeh.2008.11.006
PG 7
WC Behavioral Sciences; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Behavioral Sciences; Endocrinology & Metabolism
GA 409KY
UT WOS:000263505800006
PM 19084531
DA 2025-06-11
ER

PT J
AU Mikusic, NLR
   Prince, PD
   Choi, MR
   Chuffa, LGA
   Simao, VA
   Castro, C
   Manucha, W
   Quesada, I
AF Mikusic, Natalia Lucia Rukavina
   Prince, Paula Denise
   Choi, Marcelo Roberto
   Chuffa, Luiz Gustavo A.
   Simao, Vinicius Augusto
   Castro, Claudia
   Manucha, Walter
   Quesada, Isabel
TI Microbiota, mitochondria, and epigenetics in health and disease:
   converging pathways to solve the puzzle
SO PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
LA English
DT Review; Early Access
DE Microbiota; Mitochondria; Epigenetics; Metabolic syndrome
ID TRIMETHYLAMINE-N-OXIDE; CHAIN FATTY-ACIDS; GUT MICROBIOTA; INTESTINAL
   MICROBIOTA; HYDROGEN-SULFIDE; INDUCED OBESITY; CROSS-TALK; BUTYRATE;
   METABOLISM; SIRT1
AB Dysbiosis, which refers to an imbalance in the composition of the gut microbiome, has been associated with a range of metabolic disorders, including type 2 diabetes, obesity, and metabolic syndrome. Although the exact mechanisms connecting gut dysbiosis to these conditions are not fully understood, various lines of evidence strongly suggest a substantial role for the interaction between the gut microbiome, mitochondria, and epigenetics. Current studies suggest that the gut microbiome has the potential to affect mitochondrial function and biogenesis through the production of metabolites. A well-balanced microbiota plays a pivotal role in supporting normal mitochondrial and cellular functions by providing metabolites that are essential for mitochondrial bioenergetics and signaling pathways. Conversely, in the context of illnesses, an unbalanced microbiota can impact mitochondrial function, leading to increased aerobic glycolysis, reduced oxidative phosphorylation and fatty acid oxidation, alterations in mitochondrial membrane permeability, and heightened resistance to cellular apoptosis. Mitochondrial activity can also influence the composition and function of the gut microbiota. Because of the intricate interplay between nuclear and mitochondrial communication, the nuclear epigenome can regulate mitochondrial function, and conversely, mitochondria can produce metabolic signals that initiate epigenetic changes within the nucleus. Given the epigenetic modifications triggered by metabolic signals from mitochondria in response to stress or damage, targeting an imbalanced microbiota through interventions could offer a promising strategy to alleviate the epigenetic alterations arising from disrupted mitochondrial signaling.
C1 [Mikusic, Natalia Lucia Rukavina; Prince, Paula Denise; Choi, Marcelo Roberto] Univ Buenos Aires, Inst Alberto C Taquini Invest Med Traslac IATIMET, CONICET, RA-1122 Buenos Aires, Argentina.
   [Mikusic, Natalia Lucia Rukavina; Choi, Marcelo Roberto] Univ Buenos Aires, Fac Farm & Bioquim, Dept Ciencias Biol, Catedra Anat & Histol, RA-1113 Buenos Aires, Argentina.
   [Prince, Paula Denise] Univ Buenos Aires, Fac Farm & Bioquim, Dept Ciencias Quim, Catedra Fisicoquim, RA-1113 Buenos Aires, Argentina.
   [Chuffa, Luiz Gustavo A.; Simao, Vinicius Augusto] UNESP Sao Paulo State Univ, Inst Biosci, Dept Struct & Funct Biol, POB 18618 689, BR-510 Botucatu, SP, Brazil.
   [Castro, Claudia; Manucha, Walter; Quesada, Isabel] Univ Nacl Cuyo, CONICET, Inst Med & Biol Expt Cuyo IMBECU, Mendoza, Argentina.
   [Manucha, Walter] Univ Nacl Cuyo, Lab Farmacol Expt Basica & Traslac, Area Farmacol, Dept Patol,Fac Ciencias Med, RA-5500 Mendoza, Argentina.
C3 Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET);
   University of Buenos Aires; University of Buenos Aires; University of
   Buenos Aires; Universidade Estadual Paulista; Consejo Nacional de
   Investigaciones Cientificas y Tecnicas (CONICET); Instituto de Medicina
   y BiologIa Experimental de Cuyo (IMBECU); University Nacional Cuyo
   Mendoza; University Nacional Cuyo Mendoza
RP Choi, MR (corresponding author), Univ Buenos Aires, Inst Alberto C Taquini Invest Med Traslac IATIMET, CONICET, RA-1122 Buenos Aires, Argentina.; Choi, MR (corresponding author), Univ Buenos Aires, Fac Farm & Bioquim, Dept Ciencias Biol, Catedra Anat & Histol, RA-1113 Buenos Aires, Argentina.; Manucha, W; Quesada, I (corresponding author), Univ Nacl Cuyo, CONICET, Inst Med & Biol Expt Cuyo IMBECU, Mendoza, Argentina.; Manucha, W (corresponding author), Univ Nacl Cuyo, Lab Farmacol Expt Basica & Traslac, Area Farmacol, Dept Patol,Fac Ciencias Med, RA-5500 Mendoza, Argentina.
EM mchoi@ffyb.uba.ar; wmanucha@fcm.uncu.edu.ar;
   iquesada@mendoza-conicet.gob.ar
RI Chuffa, Luiz Gustavo/A-4085-2010; Simão, Vinicius/AAD-5469-2021
FU ANPCyT FONCyT
FX We extend our gratitude to the developers of the ChatGPT artificial
   intelligence model, whose assistance in English language correction
   greatly contributed to the refinement of this paper.
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NR 168
TC 0
Z9 0
U1 1
U2 1
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0031-6768
EI 1432-2013
J9 PFLUG ARCH EUR J PHY
JI Pflugers Arch.
PD 2025 MAR 20
PY 2025
DI 10.1007/s00424-025-03072-w
EA MAR 2025
PG 21
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA 1LF1G
UT WOS:001467664400001
PM 40111427
DA 2025-06-11
ER

PT J
AU Shirakami, Y
   Shimizu, M
   Kubota, M
   Ohno, T
   Kochi, T
   Nakamura, N
   Sumi, T
   Tanaka, T
   Moriwaki, H
   Seishima, M
AF Shirakami, Yohei
   Shimizu, Masahito
   Kubota, Masaya
   Ohno, Tomohiko
   Kochi, Takahiro
   Nakamura, Nobuhiko
   Sumi, Takafumi
   Tanaka, Takuji
   Moriwaki, Hisataka
   Seishima, Mitsuru
TI Pentoxifylline prevents nonalcoholic steatohepatitis-related liver
   pre-neoplasms by inhibiting hepatic inflammation and lipogenesis
SO EUROPEAN JOURNAL OF CANCER PREVENTION
LA English
DT Article
DE fatty liver; lipogenesis; liver tumorigenesis; nonalcoholic
   steatohepatitis; obesity; pentoxifylline
ID C57BL/KSJ-DB/DB OBESE MICE; OXIDIZED LIPID PRODUCTS; CHAIN AMINO-ACIDS;
   HEPATOCELLULAR-CARCINOMA; FATTY LIVER; PRENEOPLASTIC LESIONS; OXIDATIVE
   STRESS; XANTHINE DERIVATIVES; METABOLIC SYNDROME; DISEASE
AB Nonalcoholic steatohepatitis (NASH) has gained attention as a hepatic manifestation associated with metabolic syndrome and one of the causes for chronic liver damage leading to hepatocellular carcinoma. Although no standard medicinal treatment for NASH has been established, pentoxifylline (PTX), a medicine used to improve circulation, has recently been reported to ameliorate the histopathological appearance of NASH. In the present study, we investigated the effects of PTX on the development of NASH and diethylnitrosamine-induced liver tumorigenesis in C57BLKS/J- +Lepr(db)/+Lepr(db) obese and diabetic mice, which are considered a rodent model for NASH-related hepatocarcinogenesis. Mice were administered diethylnitrosamine, and then they received water with or without PTX. At the time of sacrifice, the development of hepatic pre-neoplastic lesions was significantly suppressed in the PTX groups. Hepatic triglyceride contents were decreased by PTX administration. The serum levels of triglyceride, free fatty acid, and alanine aminotransferase were all decreased by PTX treatment, as was the mRNA expression of proinflammatory cytokines, macrophage-inducing chemokines, and several lipogenic genes in the liver. In-vitro studies also showed that PTX treatment decreased the expression of several lipogenic genes and chemokines in cell lines. These findings suggest that PTX prevents NASH-related liver tumorigenesis by attenuating chronic hepatic inflammation and decreasing lipogenic gene expression in the liver. Copyright (C) 2016 Wolters Kluwer Health, Inc. All rights reserved.
C1 [Shirakami, Yohei; Seishima, Mitsuru] Gifu Univ, Grad Sch Med, Dept Informat Clin Med, 1-1 Yanagido, Gifu 5011194, Japan.
   [Shirakami, Yohei; Shimizu, Masahito; Kubota, Masaya; Ohno, Tomohiko; Kochi, Takahiro; Nakamura, Nobuhiko; Sumi, Takafumi; Moriwaki, Hisataka] Gifu Univ, Grad Sch Med, Dept Gastroenterol, Gifu 5011194, Japan.
   [Tanaka, Takuji] Tokai Cytopathol Inst, Canc Res & Prevent, Gifu, Japan.
C3 Gifu University; Gifu University
RP Shirakami, Y (corresponding author), Gifu Univ, Grad Sch Med, Dept Informat Clin Med, 1-1 Yanagido, Gifu 5011194, Japan.
EM ys2443@gifu-u.ac.jp
FU Ministry of Education, Science, Sports and Culture of Japan [22790638,
   21590838]
FX This work was supported in part by Grants-in-Aid from the Ministry of
   Education, Science, Sports and Culture of Japan (No. 22790638 to M.S.
   and No. 21590838 to H.M.).
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NR 48
TC 18
Z9 18
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0959-8278
EI 1473-5709
J9 EUR J CANCER PREV
JI Eur. J. Cancer Prev.
PD MAY
PY 2016
VL 25
IS 3
BP 206
EP 215
DI 10.1097/CEJ.0000000000000172
PG 10
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA DK2QI
UT WOS:000374759100006
PM 26258810
DA 2025-06-11
ER

PT J
AU Reynolds, RM
   Walker, BR
   Syddall, HE
   Andrew, R
   Wood, PJ
   Phillips, DIW
AF Reynolds, RM
   Walker, BR
   Syddall, HE
   Andrew, R
   Wood, PJ
   Phillips, DIW
TI Is there a gender difference in the associations of birthweight and
   adult hypothalamic-pituitary-adrenal axis activity?
SO EUROPEAN JOURNAL OF ENDOCRINOLOGY
LA English
DT Article
ID CARDIOVASCULAR RISK-FACTORS; PLASMA-CORTISOL CONCENTRATIONS; RECEPTOR
   GENE-EXPRESSION; BLOOD-PRESSURE; PSYCHOLOGICAL STRESS; GESTATIONAL-AGE;
   SEX-DIFFERENCES; MEN; SECRETION; RESPONSES
AB Objective: Increased hypothalamic-pituitary-adrenal (HPA) axis activity in men of low birthweight may be an important link between early life and the adult metabolic syndrome. In animal models females are more sensitive than males to HPA axis programming, but whether gender influences susceptibility in humans is unknown.
   Design: Birth cohort study Methods: We studied 106 women aged 67-78 years, from Hertfordshire, UK, in whom birthweight was recorded. Negative feedback sensitivity was assessed by an overnight low-dose (0.25 mg) dexamethasone suppression test, and adrenal sensitivity by a low-dose (1 mug) ACTH(1-24) stimulation test. Cortisol and its metabolites were analysed in a 24 h urine collection. Data were compared with previously published identical measurements in 205 men aged 66-77 years from the same cohort.
   Results: In women, plasma cortisol levels after dexamethasone were lower (P < 0.0001) and peak cortisol following ACTH(1-24) were higher (P < 0.0001) than in men, suggesting a more responsive HPA axis. As in men, women with lower birthweight had enhanced plasma cortisol responses to ACTH(1-24) (P = 0.05 for trend) but no difference in plasma cortisol after dexamethasone or in urinary cortisol metabolite excretion. The strength of the association in women was not different from that in men; a 1 lb decrease in birthweight was associated with an incremental rise in cortisol of 12.6 nmol/l (95 % confidence interval (CI) 1.4, 23.8) in men, P = 0.03, and 14.8 nmol/l (95% CI -0.4, 29.9) in women, P = 0.05 (P = 0.82 for birthweight X gender interaction). In a combined analysis of men and women adjusted for gender (n = 302), a 1 lb decrease in birthweight was associated with a 13.4 nmol/l (95% CI 4.5, 22.4) greater incremental rise in plasma cortisol, P = 0.003.
   Conclusions: Associations between lower birthweight and increased HPA axis activity are similar in men and women, supporting the hypothesis that HPA axis activation is an important mechanism underlying programming of adult disease.
C1 Univ Edinburgh, Western Gen Hosp, Endocrinol Unit, Sch Mol & Clin Med, Edinburgh EH4 2XU, Midlothian, Scotland.
   Univ Southampton, MRC, Environm Epidemiol Unit, Southampton, Hants, England.
   Southampton Gen Hosp, Reg Endocrine Unit, Southampton SO9 4XY, Hants, England.
C3 University of Edinburgh; University of Southampton; University of
   Southampton
RP Univ Edinburgh, Western Gen Hosp, Endocrinol Unit, Sch Mol & Clin Med, Edinburgh EH4 2XU, Midlothian, Scotland.
EM r.reynolds@ed.ac.uk
RI Andrew, Ruth/C-2727-2008; Reynolds, Rebecca M/C-3044-2008
OI Reynolds, Rebecca M/0000-0001-6226-8270; Syddall,
   Holly/0000-0003-0171-0306; Andrew, Ruth/0000-0002-6916-2994
CR [Anonymous], MOTHERS BABIES HLTH
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NR 33
TC 51
Z9 52
U1 0
U2 1
PU BIOSCIENTIFICA LTD
PI BRISTOL
PA EURO HOUSE, 22 APEX COURT WOODLANDS, BRADLEY STOKE, BRISTOL BS32 4JT,
   ENGLAND
SN 0804-4643
EI 1479-683X
J9 EUR J ENDOCRINOL
JI Eur. J. Endocrinol.
PD FEB
PY 2005
VL 152
IS 2
BP 249
EP 253
DI 10.1530/eje.1.01846
PG 5
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 901LI
UT WOS:000227283600013
PM 15745933
OA Bronze
DA 2025-06-11
ER

PT J
AU Bouchard, J
   Raj, P
   Yu, LP
   Sobhi, B
   Malalgoda, M
   Malunga, L
   Netticadan, T
   Thandapilly, SJ
AF Bouchard, Jenny
   Raj, Pema
   Yu, Liping
   Sobhi, Babak
   Malalgoda, Maneka
   Malunga, Lovemore
   Netticadan, Thomas
   Thandapilly, Sijo Joseph
TI Oat protein modulates cholesterol metabolism and improves cardiac
   systolic function in high fat, high sucrose fed rats
SO APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
LA English
DT Article
DE oat protein; metabolic syndrome; HMG-CoAR; high-fat; high-sucrose diet;
   systolic heart function
ID INSULIN-RESISTANT; HIGH-CARBOHYDRATE; ARGININE LYSINE; GUT MICROBIOME;
   MODEL; METAANALYSIS; RESVERATROL; HYPERTROPHY; DYSFUNCTION; MECHANISMS
AB Oats are recognized to provide many health benefits that are mainly associated with its dietary fibre, beta-glucan. However, the protein derived from oats is largely understudied with respect to its ability to maintain health and attenuate risk factors of chronic diseases. The goal of the current study was to investigate the metabolic effects of oat protein consumption in lieu of casein as the protein source in high fat, high sucrose (HF/HS) fed Wistar rats. Four-week-old rats were divided into three groups and were fed three different experimental diets: a control diet with casein as the protein source, an HF/HS diet with casein, or an HF/HS diet with oat protein for 16 weeks. Heart structure and function were determined by echocardiography. Blood pressure measurements, an oral glucose tolerance test, and markers of cholesterol metabolism, oxidative stress, inflammation, and liver and kidney damage were also performed. Our study results show that incorporation of oat protein in the diet was effective in preserving systolic heart function in HF/HS fed rats. Oat protein significantly reduced serum total and low-density lipoprotein cholesterol levels. Furthermore, oat protein normalized liver HMG-CoAR activity, which, to our knowledge, is the first time this has been reported in the literature. Therefore, our research suggests that oat protein can provide hypocholesterolemic and cardioprotective benefits in a diet-induced model of metabolic syndrome.
C1 [Bouchard, Jenny; Yu, Liping; Sobhi, Babak; Malunga, Lovemore; Netticadan, Thomas; Thandapilly, Sijo Joseph] Agr & Agrifood Canada, Morden Res & Dev Ctr, Morden, MB R6M 1Y5, Canada.
   [Bouchard, Jenny; Raj, Pema; Yu, Liping; Malunga, Lovemore; Netticadan, Thomas; Thandapilly, Sijo Joseph] Canadian Ctr Agrifood Res Hlth & Med, Winnipeg, MB R2H 2A6, Canada.
   [Bouchard, Jenny; Sobhi, Babak; Malunga, Lovemore; Thandapilly, Sijo Joseph] Univ Manitoba, Richardson Ctr Food Technol & Res, Winnipeg, MB R3T 2N2, Canada.
   [Bouchard, Jenny; Malalgoda, Maneka; Malunga, Lovemore; Thandapilly, Sijo Joseph] Univ Manitoba, Dept Food & Human Nutr Sci, Winnipeg, MB R3T 2N2, Canada.
   [Netticadan, Thomas] Univ Manitoba, Dept Physiol & Pathophysiol, Winnipeg, MB R3E 0J9, Canada.
C3 Agriculture & Agri Food Canada; University of Manitoba; University of
   Manitoba; University of Manitoba
RP Netticadan, T; Thandapilly, SJ (corresponding author), Agr & Agrifood Canada, Morden Res & Dev Ctr, Morden, MB R6M 1Y5, Canada.; Netticadan, T; Thandapilly, SJ (corresponding author), Canadian Ctr Agrifood Res Hlth & Med, Winnipeg, MB R2H 2A6, Canada.; Thandapilly, SJ (corresponding author), Univ Manitoba, Richardson Ctr Food Technol & Res, Winnipeg, MB R3T 2N2, Canada.; Thandapilly, SJ (corresponding author), Univ Manitoba, Dept Food & Human Nutr Sci, Winnipeg, MB R3T 2N2, Canada.; Netticadan, T (corresponding author), Univ Manitoba, Dept Physiol & Pathophysiol, Winnipeg, MB R3E 0J9, Canada.
EM thomas.netticadan@agr.gc.ca; sijo.joseph@agr.gc.ca
OI malunga, lovemore nkhata/0000-0003-0093-1051; netticadan,
   thomas/0000-0002-6403-8142; Malalgoda, Maneka/0000-0002-0342-0751
FU Agriculture and Agri-Food Canada's Agri-Science Program in collaboration
   with Prairie Oat Growers Association [3672]
FX This research was funded by Agriculture and Agri-Food Canada's
   Agri-Science Program in collaboration with Prairie Oat Growers
   Association (grant #3672) .
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NR 67
TC 2
Z9 2
U1 2
U2 5
PU CANADIAN SCIENCE PUBLISHING
PI OTTAWA
PA 123 Slater Street, Suite 610, OTTAWA, ON K1P 5H2, CANADA
SN 1715-5312
EI 1715-5320
J9 APPL PHYSIOL NUTR ME
JI Appl. Physiol. Nutr. Metab.
PD JUN
PY 2024
VL 49
IS 6
BP 738
EP 750
DI 10.1139/apnm-2023-0440
EA MAR 2024
PG 13
WC Nutrition & Dietetics; Physiology; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics; Physiology; Sport Sciences
GA TF4Z4
UT WOS:001233247200001
PM 38477294
DA 2025-06-11
ER

PT J
AU Nakatsu, Y
   Seno, Y
   Kushiyama, A
   Sakoda, H
   Fujishiro, M
   Katasako, A
   Mori, K
   Matsunaga, Y
   Fukushima, T
   Kanaoka, R
   Yamamotoya, T
   Kamata, H
   Asano, T
AF Nakatsu, Yusuke
   Seno, Yasuyuki
   Kushiyama, Akifumi
   Sakoda, Hideyuki
   Fujishiro, Midori
   Katasako, Aya
   Mori, Keiichi
   Matsunaga, Yasuka
   Fukushima, Toshiaki
   Kanaoka, Ryuhei
   Yamamotoya, Takeshi
   Kamata, Hideaki
   Asano, Tomoichiro
TI The xanthine oxidase inhibitor febuxostat suppresses development of
   nonalcoholic steatohepatitis in a rodent model
SO AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
LA English
DT Article
DE uric acid; nonalcoholic steatohepatitis; xanthine oxidase inhibitor;
   hyperuricemia; febuxostat
ID SERUM URIC-ACID; METABOLIC SYNDROME; DISEASE; ATHEROSCLEROSIS;
   OXIDOREDUCTASE; HYPERTENSION; FRUCTOSE; INJURY
AB Xanthine oxidase (XO) is an enzyme involved in the production of uric acid (UA) from purine nucleotides. Numerous recent studies have revealed the likelihood of metabolic syndrome including nonalcoholic fatty liver disease (NAFLD) or steatohepatitis (NASH) to be related to hyperuricemia. However, it remains unclear whether elevated serum UA during the development of NAFLD or NASH is a cause or a consequence of these diseases. In this study, the XO inhibitor febuxostat was administered to two types of NASH model mice. Febuxostat exerted a strong protective effect against NASH development induced by a high-fat diet containing trans fatty acid (HFDT). In contrast, methionine choline-deficient-diet-induced NASH development not accompanied by hyperuricemia showed no UA normalization, suggesting that the ameliorating effect of febuxostat occurs via the normalization of hyperuricemia itself and/or accompanying molecular mechanism(s) such as oxidative stress. In the HFDT-fed mice, hyperuricemia, elevated alanine aminotransferase, and increased Tunnel-positive cells in the liver were normalized by febuxostat administration. In addition, upregulation of fatty acid oxidation-related genes, fibrotic change, and increases in collagen deposition, inflammatory cytokine expressions, and lipid peroxidation in the HFDT-fed mice were also normalized by febuxostat administration. Taken together, these observations indicate that administration of febuxostat has a protective effect against HFDT-induced NASH development, suggesting the importance of XO in its pathogenesis. Thus XO inhibitors are potentially potent therapies for patients with NASH, particularly that associated with hyperuricemia.
C1 [Nakatsu, Yusuke; Seno, Yasuyuki; Katasako, Aya; Mori, Keiichi; Matsunaga, Yasuka; Fukushima, Toshiaki; Kanaoka, Ryuhei; Yamamotoya, Takeshi; Kamata, Hideaki; Asano, Tomoichiro] Hiroshima Univ, Grad Sch Med, Dept Med Sci, Hiroshima, Hiroshima, Japan.
   [Kushiyama, Akifumi] Asahi Life Fdn, Inst Adult Dis, Div Diabet & Metab, Tokyo, Japan.
   [Sakoda, Hideyuki] Miyazaki Univ, Fac Med, Dept Internal Med, Div Neurol Respirol Endocrinol & Metab, Miyazaki, Japan.
   [Fujishiro, Midori] Univ Tokyo, Dept Internal Med, Grad Sch Med, Tokyo, Japan.
C3 Hiroshima University; Asahi Life Foundation; University of Miyazaki;
   University of Tokyo
RP Asano, T (corresponding author), Hiroshima Univ, Grad Sch Med, Dept Med Sci, Minami Ku, 1-2-3 Kasumi, Hiroshima, Hiroshima, Japan.
EM tasano@hiroshima-u.ac.jp
RI 祐介, 中津/AAP-8396-2020; Kamata, Hideaki/N-3907-2017; Kushiyama,
   Akifumi/W-5988-2019
OI Nakatsu, Yusuke/0000-0003-3279-1276; Kushiyama,
   Akifumi/0000-0003-1385-7487
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NR 26
TC 60
Z9 62
U1 1
U2 30
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0193-1857
EI 1522-1547
J9 AM J PHYSIOL-GASTR L
JI Am. J. Physiol.-Gastroint. Liver Physiol.
PD JUL 1
PY 2015
VL 309
IS 1
BP G42
EP G51
DI 10.1152/ajpgi.00443.2014
PG 10
WC Gastroenterology & Hepatology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Physiology
GA CM2GQ
UT WOS:000357498300005
PM 25999428
DA 2025-06-11
ER

PT J
AU Del Chierico, F
   Gnani, D
   Vernocchi, P
   Petrucca, A
   Alisi, A
   Dallapiccola, B
   Nobili, V
   Lorenza, P
AF Del Chierico, Federica
   Gnani, Daniela
   Vernocchi, Pamela
   Petrucca, Andrea
   Alisi, Anna
   Dallapiccola, Bruno
   Nobili, Valerio
   Lorenza, Putignani
TI Meta-Omic Platforms to Assist in the Understanding of NAFLD Gut
   Microbiota Alterations: Tools and Applications
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE metabolic syndrome; data integration; non-alcoholic steatohepatitis;
   pediatric patients; meta-omic platforms; diet; obesity; systems biology;
   non-alcoholic fatty liver disease; gut microbiota
ID FATTY LIVER-DISEASE; NONALCOHOLIC STEATOHEPATITIS; INTESTINAL
   MICROBIOTA; INSULIN-RESISTANCE; OXIDATIVE STRESS; ENERGY-BALANCE;
   OBESITY; IMPACT; PATHOPHYSIOLOGY; INFLAMMATION
AB Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease worldwide as a result of the increasing prevalence of obesity, starting from early life stages. It is characterized by a spectrum of liver diseases ranging from simple fatty liver (NAFL) to steatohepatitis (NASH), with a possible progression to fibrosis, thus increasing liver-related morbidity and mortality. NAFLD development is driven by the co-action of several risk factors, including obesity and metabolic syndrome, which may be both genetically induced and diet-related. Recently, particular attention has been paid to the gut-liver axis, which may play a physio-pathological role in the onset and progression of the disease. The gut microbiota is intended to act as a bioreactor that can guarantee autonomous metabolic and immunological functions and that can drive functional strategies within the environment of the body in response to external stimuli. The complexity of the gut microbiota suggests that it behaves as an organ. Therefore, the concept of the gut-liver axis must be complemented with the gut-microbiota-liver network due to the high intricacy of the microbiota components and metabolic activities; these activities form the active diet-driven power plant of the host. Such complexity can only be revealed using systems biology, which can integrate clinical phenomics and gut microbiota data.
C1 [Del Chierico, Federica; Vernocchi, Pamela; Petrucca, Andrea; Lorenza, Putignani] IRCCS, Bambino Gesu Childrens Hosp, Unit Parasitol, I-00165 Rome, Italy.
   [Del Chierico, Federica; Vernocchi, Pamela; Petrucca, Andrea; Lorenza, Putignani] IRCCS, Bambino Gesu Childrens Hosp, Unit Metagen, I-00165 Rome, Italy.
   [Gnani, Daniela; Alisi, Anna; Nobili, Valerio] IRCCS, Bambino Gesu Childrens Hosp, Liver Res Unit, I-00165 Rome, Italy.
   [Vernocchi, Pamela] Univ Bologna, Interdept Ctr Ind Res CIRI AGRIFOOD, I-47521 Cesena, FC, Italy.
   [Petrucca, Andrea] St Andrea Hosp, Dept Diagnost Sci, I-00185 Rome, Italy.
   [Dallapiccola, Bruno] IRCCS, Bambino Gesu Childrens Hosp, Sci Directorate, I-00165 Rome, Italy.
   [Nobili, Valerio] IRCCS, Bambino Gesu Childrens Hosp, Hepatometab Dis Unit, I-00165 Rome, Italy.
C3 IRCCS Bambino Gesu; IRCCS Bambino Gesu; IRCCS Bambino Gesu; University
   of Bologna; Sapienza University Rome; Azienda Ospedaliera Sant'Andrea;
   IRCCS Bambino Gesu; IRCCS Bambino Gesu
RP Lorenza, P (corresponding author), IRCCS, Bambino Gesu Childrens Hosp, Unit Parasitol, Piazza St Onofrio 4, I-00165 Rome, Italy.
EM federica.delchierico@opbg.net; daniela.gnani@yahoo.it;
   pamela.vernocchi@opbg.net; andrea_petrucca@yahoo.com;
   anna.alisi@opbg.net; bruno.dallapiccola@opbg.net;
   valerio.nobili@opbg.net; lorenza.putignani@opbg.net
RI gnani, Daniela/AAN-1929-2020; Nobili, Valerio/K-8670-2018; Alisi,
   Anna/A-6469-2010; Vernocchi, Pamela/K-2534-2016; Del Chierico,
   Federica/J-4373-2016; Dallapiccola, Bruno/K-8692-2016; putignani,
   lorenza/K-3409-2016
OI nobili, valerio/0000-0002-4570-3979; Vernocchi,
   Pamela/0000-0001-8007-5632; Alisi, Anna/0000-0001-7241-6329; Del
   Chierico, Federica/0000-0002-4204-4736; Gnani,
   Daniela/0000-0002-5857-3456; Dallapiccola, Bruno/0000-0002-5031-1013;
   putignani, lorenza/0000-0003-0134-2830
FU Ministry of Health, Current Research [RC 201302P002991, RC 321
   201302G003050]
FX This work was supported by the Ministry of Health, Current Research (RC
   201302P002991 and RC 321 201302G003050) assigned to LP by the Pediatric
   Hospital Bambino Gesu, IRCCS. The authors would like to especially thank
   Fondazione Luca Barbareschi, Onlus, Dalla parte dei Bambini.
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NR 124
TC 23
Z9 24
U1 0
U2 37
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD JAN
PY 2014
VL 15
IS 1
BP 684
EP 711
DI 10.3390/ijms15010684
PG 28
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA AG9YM
UT WOS:000335776100039
PM 24402126
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Hunter, R
   Ivy, JR
   Bailey, MA
AF Hunter, RobertW.
   Ivy, Jessica R.
   Bailey, Matthew A.
TI Glucocorticoids and renal Na<SUP>+</SUP> transport: implications for
   hypertension and salt sensitivity
SO JOURNAL OF PHYSIOLOGY-LONDON
LA English
DT Review
ID 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1; COLLECTING DUCT CELLS;
   APPARENT MINERALOCORTICOID EXCESS; RECEPTOR KNOCKOUT MICE; METABOLIC
   SYNDROME; CL-COTRANSPORTER; SODIUM-TRANSPORT; ANGIOTENSIN-II;
   RAT-KIDNEY; DIABETES-MELLITUS
AB The clinical manifestations of glucocorticoid excess include central obesity, hyperglycaemia, dyslipidaemia, electrolyte abnormalities and hypertension. A century on from Cushing's original case study, these cardinal features are prevalent in industrialized nations. Hypertension is the major modifiable risk factor for cardiovascular and renal disease and reflects underlying abnormalities of Na+ homeostasis. Aldosterone is a master regulator of renal Na+ transport but here we argue that glucocorticoids are also influential, particularly during moderate excess. The hypothalamic-pituitary-adrenal axis can affect renal Na+ homeostasis on multiple levels, systemically by increasing mineralocorticoid synthesis and locally by actions on both the mineralocorticoid and glucocorticoid receptors, both of which are expressed in the kidney. The kidney also expresses both of the 11 beta-hydroxysteroid dehydrogenase (11 beta HSD) enzymes. The intrarenal generation of active glucocorticoid by 11 beta HSD1 stimulates Na+ reabsorption; failure to downregulate the enzyme during adaption to high dietary salt causes salt-sensitive hypertension. The deactivation of glucocorticoid by 11 beta HSD2 underpins the regulatory dominance for Na+ transport of mineralocorticoids and defines the 'aldosterone-sensitive distal nephron'. In summary, glucocorticoids can stimulate renal transport processes conventionally attributed to the renin-angiotensin-aldosterone system. Importantly, Na+ and volume homeostasis do not exert negative feedback on the hypothalamic-pituitary-adrenal axis. These actions are therefore clinically relevant and may contribute to the pathogenesis of hypertension in conditions associated with elevated glucocorticoid levels, such as the metabolic syndrome and chronic stress.
C1 [Hunter, RobertW.; Ivy, Jessica R.; Bailey, Matthew A.] Univ Edinburgh, British Heart Fdn Ctr Cardiovasc Sci, Edinburgh, Midlothian, Scotland.
C3 University of Edinburgh
RP Bailey, MA (corresponding author), Univ BHF Ctr Cardiovasc Sci, Queens Med Res Inst, 47 Little France Crescent, Edinburgh EH16 4TJ, Midlothian, Scotland.
EM matthew.bailey@ed.ac.uk
RI Bailey, Matthew/AAH-3395-2020; Ivy, Jessica/AAY-6150-2021; Hunter,
   Robert/AFF-6736-2022
OI Bailey, Matthew/0000-0003-4244-5668; Hunter, Robert/0000-0003-2344-8978;
   Ivy, Jessica/0000-0003-1004-4376
FU British Heart Foundation Centre of Research Excellence Award; Kidney
   Research UK; Wellcome Trust; British Heart Foundation
FX We thank Dr Chris Kenyon for his critical appraisal of the manuscript
   and for Fig. 1, Prof. Stuart Wilson for discussion of data, The British
   Heart Foundation Centre of Research Excellence Award and Kidney Research
   UK for research funding. RWH was supported by a Clinical Research
   Fellowship from The Wellcome Trust; JRI by a British Heart Foundation
   4-year PhD studentship.
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NR 74
TC 54
Z9 60
U1 0
U2 18
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-3751
EI 1469-7793
J9 J PHYSIOL-LONDON
JI J. Physiol.-London
PD APR 15
PY 2014
VL 592
IS 8
BP 1731
EP 1744
DI 10.1113/jphysiol.2013.267609
PG 14
WC Neurosciences; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Physiology
GA AE6OT
UT WOS:000334114100006
PM 24535442
OA hybrid, Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Taveira, TH
   Wu, WC
   Tschibelu, E
   Borsook, D
   Simonson, DC
   Yamamoto, R
   Langleben, DD
   Swift, R
   Elman, I
AF Taveira, Tracey H.
   Wu, Wen-Chih
   Tschibelu, Evelyne
   Borsook, David
   Simonson, Donald C.
   Yamamoto, Rinah
   Langleben, Daniel D.
   Swift, Robert
   Elman, Igor
TI The effect of naltrexone on body fat mass in olanzapine-treated
   schizophrenic or schizoaffective patients: A randomized double-blind
   placebo-controlled pilot study
SO JOURNAL OF PSYCHOPHARMACOLOGY
LA English
DT Article
DE Opioid; metabolic syndrome; weight gain; metabolism; liver function
   tests; lipid
ID INDUCED WEIGHT-GAIN; SMOKING-CESSATION; METABOLIC ABNORMALITIES;
   FOOD-INTAKE; PLASMA; INDIVIDUALS; VALIDATION; RELEASE; STRESS; INDEX
AB Olanzapine (OLZ), a commonly prescribed second generation antipsychotic drug, is associated with obesity and metabolic syndrome and may contribute to increased cardiovascular morbidity and mortality. Opioidergic neurotransmission may be implicated in the development of these metabolic disturbances. The objective of this study was to assess the effects of opioid blockade on OLZ-treated patients' metabolic status. Patients with schizophrenia or schizoaffective disorder (n=30) on a stable dose of OLZ were randomized in a double-blind fashion to receive an opioid receptor antagonist, naltrexone (NTX), (n=14) or placebo (n=16). The primary outcome measure was the change in body mass index (BMI) at 12 weeks. Secondary measures included body fat and fat-free mass, along with homeostasis model assessment-estimated insulin resistance (HOMA-IR), plasma lipids and liver function tests (LFTs). There was no significant change in BMI between the treatment arms. However, in comparison to the OLZ + placebo combination, the OLZ + NTX group displayed a significant decrease in the fat and increase in fat-free mass along with a trend towards improvement in HOMA-IR values. There were no significant differences in plasma lipids and LFTs. These findings suggest that addition of NTX to OLZ may attenuate OLZ-induced body fat mass gain. A larger study of longer duration will be needed to confirm these results.
C1 [Taveira, Tracey H.; Wu, Wen-Chih; Swift, Robert; Elman, Igor] Providence VA Med Ctr, Providence, RI USA.
   [Taveira, Tracey H.; Wu, Wen-Chih] Univ Rhode Isl, Kingston, RI 02881 USA.
   [Taveira, Tracey H.; Wu, Wen-Chih; Swift, Robert] Brown Univ, Warren Alpert Med Sch, Providence, RI 02912 USA.
   [Tschibelu, Evelyne; Borsook, David; Yamamoto, Rinah] McLean Hosp, Clin Psychopathol Lab, Belmont, MA 02178 USA.
   [Borsook, David; Simonson, Donald C.; Yamamoto, Rinah; Elman, Igor] Harvard Univ, Sch Med, Cambridge, MA 02138 USA.
   [Simonson, Donald C.] Brigham & Womens Hosp, Div Endocrinol Diabet & Hypertens, Boston, MA 02115 USA.
   [Langleben, Daniel D.] Univ Penn, Dept Psychiat, Philadelphia, PA 19104 USA.
   [Elman, Igor] Cambridge Hlth Alliance, Somerville, NJ USA.
C3 US Department of Veterans Affairs; Veterans Health Administration (VHA);
   Providence VA Medical Center; University of Rhode Island; Brown
   University; Harvard University; Harvard University Medical Affiliates;
   McLean Hospital; Harvard University; Harvard University; Harvard
   University Medical Affiliates; Brigham & Women's Hospital; University of
   Pennsylvania; Harvard University; Harvard University Medical Affiliates;
   Cambridge Health Alliance
RP Elman, I (corresponding author), Harvard Univ, Sch Med, Cambridge Hlth Alliance, 26 Cent St, Somerville, MA 02143 USA.
EM ielman@cha.harvard.edu
RI Langleben, Daniel/K-7407-2014; Elman, Igor/O-2884-2017
OI Elman, Igor/0000-0002-1345-2677
FU Eli Lilly Neuroscience Investigator-Initiated mechanism
FX The study was funded via Eli Lilly Neuroscience Investigator-Initiated
   mechanism. The funders had no role in study design, data collection and
   analysis, decision to publish, or preparation of the manuscript.
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NR 43
TC 28
Z9 30
U1 0
U2 8
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0269-8811
EI 1461-7285
J9 J PSYCHOPHARMACOL
JI J. Psychopharmacol.
PD APR
PY 2014
VL 28
IS 4
BP 395
EP 400
DI 10.1177/0269881113509904
PG 6
WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA AC3UR
UT WOS:000332447200011
PM 24218048
DA 2025-06-11
ER

PT J
AU Chen, Q
   Wang, TT
   Li, J
   Wang, SJ
   Qiu, F
   Yu, HY
   Zhang, Y
   Wang, T
AF Chen, Qian
   Wang, Tingting
   Li, Jian
   Wang, Sijian
   Qiu, Feng
   Yu, Haiyang
   Zhang, Yi
   Wang, Tao
TI Effects of Natural Products on Fructose-Induced Nonalcoholic Fatty Liver
   Disease (NAFLD)
SO NUTRIENTS
LA English
DT Review
DE fructose-induced NAFLD; lipogenesis; natural products; mitochondrial
   dysfunction; inflammatory pathways; insulin resistance
ID INDUCED INSULIN-RESISTANCE; OXIDATIVE STRESS; METABOLIC SYNDROME;
   HEPATIC STEATOSIS; GENE-EXPRESSION; POTENTIAL ROLE; DIET; GLUCOSE; RATS;
   CONSUMPTION
AB As a sugar additive, fructose is widely used in processed foods and beverages. Excessive fructose consumption can cause hepatic steatosis and dyslipidemia, leading to the development of metabolic syndrome. Recent research revealed that fructose-induced nonalcoholic fatty liver disease (NAFLD) is related to several pathological processes, including: (1) augmenting lipogenesis; (2) leading to mitochondrial dysfunction; (3) stimulating the activation of inflammatory pathways; and (4) causing insulin resistance. Cellular signaling research indicated that partial factors play significant roles in fructose-induced NAFLD, involving liver X receptor (LXR)alpha, sterol regulatory element binding protein (SREBP)-1/1c, acetyl-CoA carboxylase (ACC), fatty acid synthase (FAS), stearoyl-CoA desaturase (SCD), peroxisome proliferator-activated receptor alpha (PPAR alpha), leptin nuclear factor-erythroid 2-related factor 2 (Nrf2), nuclear factor kappa B (NF-KB), tumor necrosis factor alpha (TNF-alpha), c-Jun amino terminal kinase (JNK), phosphatidylinositol 3-kinase (PI3K) and adenosine 5'-monophosphate (AMP)-activated protein kinase (AMPK). Until now, a series of natural products have been reported as regulators of NAFLD in vivo and in vitro. This paper reviews the natural products (e.g., curcumin, resveratrol, and (-)-epicatechin) and their mechanisms of ameliorating fructose-induced NAFLD over the past years. Although, as lead compounds, natural products usually have fewer activities compared with synthesized compounds, it will shed light on studies aiming to discover new drugs for NAFLD.
C1 [Chen, Qian; Wang, Tingting; Yu, Haiyang; Wang, Tao] Tianjin Univ Tradit Chinese Med, Inst Tradit Chinese Med, Tianjin Key Lab TCM Chem & Anal, 312 Anshan Rd, Tianjin 300193, Peoples R China.
   [Li, Jian; Wang, Sijian; Qiu, Feng; Zhang, Yi] Tianjin State Key Lab Modern Chinese Med, 312 Anshanxi Rd, Tianjin 300193, Peoples R China.
C3 Tianjin University of Traditional Chinese Medicine
RP Wang, T (corresponding author), Tianjin Univ Tradit Chinese Med, Inst Tradit Chinese Med, Tianjin Key Lab TCM Chem & Anal, 312 Anshan Rd, Tianjin 300193, Peoples R China.; Zhang, Y (corresponding author), Tianjin State Key Lab Modern Chinese Med, 312 Anshanxi Rd, Tianjin 300193, Peoples R China.
EM serafinachen@163.com; 18202682964@163.com; beyondwill@126.com;
   15122587883@163.com; fengqiu20070118@163.com;
   yuhaiyang19830116@hotmail.com; zhwwxzh@263.net; wangtao@tjutcm.edu.cn
RI Haiyang, Yu/ACP-8009-2022; Wang, SiJian/KTI-4031-2024; wang,
   tingting/AAK-2640-2020; WANG, Tao/AAG-3474-2020
OI Li, Jian/0000-0003-4517-5819; Chen, Qian/0000-0002-4642-8577
FU National Natural Science Foundation of China [81673703, 81430095]
FX Supported by National Natural Science Foundation of China (81673703,
   81430095).
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NR 62
TC 151
Z9 158
U1 9
U2 161
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 2072-6643
J9 NUTRIENTS
JI Nutrients
PD FEB
PY 2017
VL 9
IS 2
AR 96
DI 10.3390/nu9020096
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA EO9QL
UT WOS:000397023100009
PM 28146130
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Bhandari, P
AF Bhandari, Pratibha
TI Prevalence of cardiovascular risk factors among Asian migrant workers in
   South Korea
SO PLOS ONE
LA English
DT Article
ID METABOLIC SYNDROME; DISEASE; HEALTH; MORTALITY; STRESS
AB BackgroundThe burden of non-communicable diseases is rapidly increasing among young adults in middle- and low-income countries. Asian migrant workers continue to be a significant contributor to South Korea's economy; however, their cardiovascular health is neglected. We explored the prevalence of cardiovascular risk factors among Asian migrant workers in South Korea. MethodsCross-sectional survey, anthropometric measurements, blood pressure measurements, and biochemical tests including triglyceride, high-density lipoprotein, low-density lipoprotein, total cholesterol, fasting blood sugar, HbA1c, and C-reactive protein levels were conducted in 141 Asian migrant workers in South Korea. ResultsThe mean age of the participants was 31.3 (5.6) years. Of the participants, 14.8% were current smokers, and 47.5% consumed alcohol. The prevalence of overweight/obesity was 32.4%. The prevalence of hypertension and dyslipidemia were 51.2% and 64.6%, respectively. Of the participants, 98.5% had an increased waist circumference; elevated HbA1C and C-reactive protein was seen in 20.9% and 4.3%, respectively. The prevalence of metabolic syndrome was 5.5%. Clustering of two or more risk factors was seen in 45% of the participants. Factors associated with a high risk of cardiovascular diseases (clustering of two or more risk factors) were age (odds ratio 1.16, p < 0.01) and smoking (4.98, p < 0.05). ConclusionThe prevalence of cardiovascular risk factors was alarmingly high among Asian migrant workers employed in South Korea. Efforts to mitigate and eliminate those risk factors are urgently required.
C1 [Bhandari, Pratibha] Univ Technol Sydney, Sch Nursing & Midwifery, Sydney, NSW, Australia.
C3 University of Technology Sydney
RP Bhandari, P (corresponding author), Univ Technol Sydney, Sch Nursing & Midwifery, Sydney, NSW, Australia.
EM pratibha.bhandari@uts.edu.au
RI Bhandari, Pratibha/HPG-7084-2023
OI Bhandari, Pratibha/0000-0002-1611-1827
FU National Research Foundation of Korea (NRF) - Korea government (Ministry
   of Science and Technology) [2020R1G1A1005581]
FX The author is grateful to Dr. Binayak Bhandari, members of Daejeon
   Nepali Samaj, Mr. Issac Pyakurel, Mr. Kamrul Hasan, Mrs. Manju Gurung,
   Mr. Ramesh Bidari, and Mr. Suman Rai for their help in recruiting study
   participants; and to all the participants, hospitals and community
   organizations that supported this study in various ways.
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NR 45
TC 0
Z9 0
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U2 0
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JUL 10
PY 2023
VL 18
IS 7
AR e0288375
DI 10.1371/journal.pone.0288375
PG 13
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA M1LW1
UT WOS:001027854200001
PM 37428813
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Agarwal, N
   Bustamante, CER
   Wu, HZ
   Armamento-Villareal, R
   Lake, JE
   Balasubramanyam, A
   Hartig, SM
AF Agarwal, Neeti
   Bustamante, Claudia E. Ramirez
   Wu, Huaizhu
   Armamento-Villareal, Reina
   Lake, Jordan E.
   Balasubramanyam, Ashok
   Hartig, Sean M.
TI Heightened levels of plasma growth differentiation factor 15 in men
   living with HIV
SO PHYSIOLOGICAL REPORTS
LA English
DT Article
DE ART; energy balance; GDF15; HIV; metabolic syndrome
ID RISK-FACTORS; ANTIRETROVIRAL THERAPY; WEIGHT-LOSS; GDF15; DYSFUNCTION;
   RECEPTOR; STRESS; LIPODYSTROPHY; ASSOCIATION; PREVALENCE
AB Plasma biomarkers that reflect energy balance disorders in people living with HIV (PLWH) remain limited. Growth differentiation factor 15 (GDF15) abundance in plasma of mice and humans induces negative energy balance but also becomes highly elevated in obesity and other metabolic diseases. We sought to compare plasma GDF15 levels in PLWH and HIV-negative persons and mouse models expressing the HIV accessory protein Vpr (that recapitulate HIV-associated metabolic disorders) and determine their relationship to metabolic parameters. We measured liver Gdf15 mRNA levels and plasma GDF15 levels in male Vpr mice and littermate controls. In parallel, we analyzed plasma GDF15 levels in 18 male PLWH on stable, long-term antiretroviral therapy and 13 HIV-negative men (6 healthy controls and 7 with metabolic syndrome). Plasma GDF15 levels were correlated with anthropometric and immune cell parameters in humans. Gene expression analysis of Vpr mouse liver demonstrated elevated Gdf15 mRNA. Plasma GDF15 levels were also higher in Vpr mouse models. Levels of plasma GDF15 in PLWH were greater than in both HIV-negative groups and correlated positively with the CD4/CD8 T cell ratio in PLWH. Plasma GDF15 levels correlated positively with age in the HIV-negative subjects but not in PLWH. Since GDF15 levels predict fatty liver disease and energy balance disorders, further studies are warranted to determine the effect of GDF15 in mediating the metabolic disturbances that occur in Vpr mice and PLWH.
C1 [Agarwal, Neeti; Bustamante, Claudia E. Ramirez; Armamento-Villareal, Reina; Balasubramanyam, Ashok; Hartig, Sean M.] Baylor Coll Med, Div Diabet Endocrinol & Metab, Houston, TX 77030 USA.
   [Wu, Huaizhu] Baylor Coll Med, Atherosclerosis & Lipoprot Res, Houston, TX 77030 USA.
   [Armamento-Villareal, Reina] Michael E DeBakey VA Med Ctr, Ctr Translat Res Inflammatory Dis, Houston, TX USA.
   [Lake, Jordan E.] Univ Texas Hlth Sci Ctr Houston, Div Infect Dis, Dept Internal Med, McGovern Med Sch, Houston, TX 77030 USA.
   [Hartig, Sean M.] Baylor Coll Med, Dept Mol & Cellular Biol, Houston, TX 77030 USA.
C3 Baylor College of Medicine; Baylor College of Medicine; Baylor College
   of Medicine; Baylor College Medical Hospital; University of Texas
   System; University of Texas Health Science Center Houston; Baylor
   College of Medicine
RP Balasubramanyam, A; Hartig, SM (corresponding author), Baylor Coll Med, Div Diabet Endocrinol & Metab, Houston, TX 77030 USA.
EM ashokb@bcm.edu; hartig@bcm.edu
RI Hartig, Sean/HKN-8506-2023; Villareal, Reina/AAH-6028-2019
OI Hartig, Sean/0000-0002-2695-2072; Ramirez Bustamante,
   Claudia/0000-0002-1562-6247
FU National Institutes of Health [P30 AG028748, K23 AI110532, R01DK126042,
   5P30 AI028697, R01DK114356, R01DK121348]; American Diabetes Association
   [1-18-IBS-105]; VA grant [101CX00042403]; Rutherford Fund for Diabetes
   Research
FX This work was funded by National Institutes of Health grants P30
   AG028748, K23 AI110532 and R01DK126042 (JEL), 5P30 AI028697, R01DK114356
   (SMH), and R01DK121348 (HW). SMH is also supported by American Diabetes
   Association #1-18-IBS-105. RAV is supported by VA grant 101CX00042403,
   and AB by the Rutherford Fund for Diabetes Research. The content is
   solely the responsibility of the authors and does not necessarily
   represent the views of the US Department of Veterans Affairs or the
   United States Government.
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NR 56
TC 4
Z9 5
U1 1
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2051-817X
J9 PHYSIOL REP
JI PHYSIOL. REP.
PD MAY
PY 2022
VL 10
IS 9
AR e15293
DI 10.14814/phy2.15293
PG 10
WC Physiology
WE Emerging Sources Citation Index (ESCI)
SC Physiology
GA 0Y8MB
UT WOS:000790637700001
PM 35510313
OA Green Published
DA 2025-06-11
ER

PT J
AU Xu, CF
   Yu, CH
   Xu, L
   Miao, M
   Li, YM
AF Xu, Chengfu
   Yu, Chaohui
   Xu, Lei
   Miao, Min
   Li, Youming
TI High Serum Uric Acid Increases the Risk for Nonalcoholic Fatty Liver
   Disease: A Prospective Observational Study
SO PLOS ONE
LA English
DT Article
ID METABOLIC SYNDROME; OXIDATIVE STRESS; PREVALENCE; STEATOHEPATITIS;
   INDIVIDUALS; ASSOCIATION; POPULATION; MORTALITY; GLUCOSE
AB Nonalcoholic fatty liver disease (NAFLD) is a common form of chronic liver disease, and serum uric acid is observed to be significantly elevated in NAFLD patients. However, whether this elevation is causal, a bystander, or a consequence of NAFLD remains unclear. We performed a population-based prospective study among the employees of Zhenhai Refining & Chemical Company Ltd., Ningbo, China to investigate whether the elevation of serum uric acid has a casual role for NAFLD. A total of 6890 initially NAFLD-free subjects were followed up for 3 years. Overall, 11.80% (813/6890) subjects developed NAFLD over 3 years of follow-up. The cumulative incidence of NAFLD increased with progressively higher baseline serum uric acid levels (the cumulative incidence was 7.2%, 9.5%, 11.5%, 13.8%, and 17.2% in quintile 1, quintile 2, 3, 4 and 5, respectively; P value for trend <0.001). Cox proportional hazards regression analyses showed that serum uric acid levels were independently and positively associated with the risk for incident NAFLD; the age-, gender- and metabolic syndrome adjusted hazard ratio (95% CI) for the subjects in quintile 2, 3, 4 and 5 versus quintile 1 was 1.18 (0.91-1.54), 1.32 (1.03-1.70), 1.39 (1.09-1.78) and 1.50 (1.18-1.92), respectively. Taken together, our prospective observational study showed that elevation of serum uric acid levels independently predicts increase risk for incident NAFLD.
C1 [Xu, Chengfu; Yu, Chaohui; Xu, Lei; Li, Youming] Zhejiang Univ, Affiliated Hosp 1, Dept Gastroenterol, Coll Med, Hangzhou 310003, Zhejiang, Peoples R China.
   [Xu, Lei; Miao, Min] Ningbo 1 Hosp, Dept Gastroenterol, Ningbo, Zhejiang, Peoples R China.
C3 Zhejiang University
RP Li, YM (corresponding author), Zhejiang Univ, Affiliated Hosp 1, Dept Gastroenterol, Coll Med, Hangzhou 310003, Zhejiang, Peoples R China.
EM xiaofu@zju.edu.cn
RI Xu, Chengfu/HTL-9950-2023
OI Ma, Han/0000-0001-9985-3035; Xu, Chengfu/0000-0002-6172-1253
FU Chinese State Key Project for High-tech [2006AA02A308]; National Science
   & Technology Pillar Program [2008BAI52B03]; National Natural Science
   Foundation of China [30871154]; Science & Technology Foundation of
   Zhejiang Province [2008C13027-1]
FX This study was supported by Chinese State Key Project for High-tech (No.
   2006AA02A308), National Science & Technology Pillar Program (No.
   2008BAI52B03), National Natural Science Foundation of China (No.
   30871154) and Science & Technology Foundation of Zhejiang Province (No.
   2008C13027-1). The funders had no role in study design, data collection
   and analysis, decision to publish, or preparation of the manuscript.
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NR 33
TC 130
Z9 146
U1 2
U2 29
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JUL 14
PY 2010
VL 5
IS 7
AR e11578
DI 10.1371/journal.pone.0011578
PG 6
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 625HA
UT WOS:000279884900017
PM 20644649
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Dominguez, JH
   Wu, P
   Hawes, JW
   Deeg, M
   Walsh, J
   Packer, SC
   Nagase, M
   Temm, C
   Goss, E
   Peterson, R
AF Dominguez, J. H.
   Wu, P.
   Hawes, J. W.
   Deeg, M.
   Walsh, J.
   Packer, S. C.
   Nagase, M.
   Temm, C.
   Goss, E.
   Peterson, R.
TI Renal injury: Similarities and differences in male and female rats with
   the metabolic syndrome
SO KIDNEY INTERNATIONAL
LA English
DT Article
DE diabetic nephropathies; lipid peroxidation
ID LOW-DENSITY-LIPOPROTEIN; TYPE-2 DIABETES-MELLITUS; JAPANESE NIDDM
   PATIENTS; SHR/N-CORPULENT RAT; OXIDIZED LDL; ENDOTHELIAL-CELLS;
   3-HYDROXYISOBUTYRATE DEHYDROGENASE; LIPID-PEROXIDATION; SCAVENGER
   RECEPTOR; PROXIMAL TUBULES
AB The metabolic syndrome is complicated by nephropathy in humans and rats, and males are more affected than females. We hypothesized that female rats had reduced expression of glomerular oxidized low-density lipoprotein (oxLDL) receptor 1 (LOX-1), attendant glomerular oxidant injury, and renal inflammation. Three groups, obese males (OM), obese females (OF), and lean males (LM) of first-generation (F-1) hybrid rats derived from the Zucker fatty diabetic (ZDF) strain and the spontaneous hypertensive heart failure rat (SHHF/Gmi-fa) were studied from 6 to 41 weeks of age. OM had severe renal oxidant injury and renal failure. Their glomeruli expressed the LOX-1, and exhibited heavier accumulation of the lipid peroxide 4-hydroxynonenal (4-HNE). OM had compromised mitochondrial enzyme function, more renal fibrosis, and vascular leakage. Younger LM, OM, and OF ZS (ZDF/SHHF F-1 hybrid rat) rats, studied from 6 to 16 weeks of age, showed that unutilized renal lipids were comparable in OM and OF, although young OM had worse nephropathy and inflammation. In conclusion, glomerular LOX-1 expression is coupled to deposits of 4-HNE and glomerulosclerosis in OM. We presume that LOX-1 enhances glomerular uptake of oxidized lipids and renal inflammation, causing greater oxidant stress and severe glomerulosclerosis. In OF, renal protection from lipid oxidants appears to be conferred by blunted glomerular LOX-1 expression and renal inflammation.
C1 Indiana Univ, Sch Med, Dept Nephrol, Indianapolis, IN 46202 USA.
   Indianapolis Vet Adm Med Ctr, Indianapolis, IN 46202 USA.
   Indiana Univ, Sch Med, Dept Physiol, Indianapolis, IN 46202 USA.
   Indiana Univ, Sch Med, Dept Biochem, Indianapolis, IN 46202 USA.
   Indiana Univ, Sch Med, Dept Mol Biol, Indianapolis, IN 46202 USA.
   Univ Tokyo, Sch Med, Bunkyo Ku, Tokyo 113, Japan.
   Indiana Univ, Sch Med, Dept Anat, Indianapolis, IN 46202 USA.
C3 Indiana University System; Indiana University Indianapolis; Indiana
   University System; Indiana University Indianapolis; Indiana University
   System; Indiana University Indianapolis; Indiana University System;
   Indiana University Indianapolis; University of Tokyo; Indiana University
   System; Indiana University Indianapolis
RP Dominguez, JH (corresponding author), Indiana Univ, Sch Med, Dept Nephrol, 111,1481 W 10th St, Indianapolis, IN 46202 USA.
EM jhdoming@iupui.edu
RI Goss, Erin/KIC-8481-2024
OI Goss, Erin/0000-0003-2541-9011
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NR 58
TC 40
Z9 45
U1 0
U2 2
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0085-2538
EI 1523-1755
J9 KIDNEY INT
JI Kidney Int.
PD JUN
PY 2006
VL 69
IS 11
BP 1969
EP 1976
DI 10.1038/sj.ki.5000406
PG 8
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 050TS
UT WOS:000238112100015
PM 16688121
OA Bronze
DA 2025-06-11
ER

PT J
AU Jansen, SWM
   van Heemst, D
   van der Grond, J
   Westendorp, R
   Oei, NYL
AF Jansen, Steffy W. M.
   van Heemst, Diana
   van der Grond, Jeroen
   Westendorp, Rudi
   Oei, Nicole Y. L.
TI Physiological responding to stress in middle-aged males enriched for
   longevity: a social stress study
SO STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS
LA English
DT Article
DE Area under the curve; blood pressure; cortisol; heart rate; healthy
   ageing; TSST
ID PSYCHOSOCIAL STRESS; CORTISOL-LEVELS; CARDIOVASCULAR REACTIVITY;
   NONAGENARIAN SIBLINGS; FAMILIAL LONGEVITY; METABOLIC SYNDROME; SALIVARY
   CORTISOL; DIABETES-MELLITUS; YOUNGER ADULTS; ELDERLY ADULTS
AB Individuals enriched for familial longevity display a lower prevalence of age-related diseases, such as cardiovascular-and metabolic diseases. Since these diseases are associated with stress and increased cortisol levels, one of the underlying mechanisms that may contribute to healthy longevity might be a more adaptive response to stress. To investigate this, male middle-aged offspring from long-lived families (n = 31) and male non-offspring (with no familial history of longevity) (n = 26) were randomly allocated to the Trier Social Stress Test or a control condition in an experimental design. Physiological (cortisol, blood pressure, heart rate) and subjective responses were measured during the entire procedure. The results showed that Offspring had lower overall cortisol levels compared to Non-offspring regardless of condition, and lower absolute cortisol output (AUCg) during stress compared to Non-Offspring, while the increase (AUCi) did not differ between groups. In addition, systolic blood pressure in Offspring was lower compared to Non-offspring during the entire procedure. At baseline, Offspring had significantly lower systolic blood pressure and reported less subjective stress than Non-offspring and showed a trend towards lower heart rate. Offspring from long-lived families might thus be less stressed prior to potentially stressful events and consequently show overall lower levels in physiological responses. Although attenuated physiological responding cannot be ruled out, lower starting points and a lower peak level in physiological responding when confronted with an actual stressor, might already limit damage due to stress over a lifetime. Lower physiological responding may also contribute to the lower prevalence of cardiovascular diseases and other stress-related diseases in healthy longevity.
C1 [Jansen, Steffy W. M.; van Heemst, Diana; Westendorp, Rudi] Leiden Univ, Med Ctr, Dept Gerontol & Geriatr, Leiden, Netherlands.
   [van der Grond, Jeroen] Leiden Univ, Med Ctr, Dept Radiol, Leiden, Netherlands.
   [Westendorp, Rudi] Univ Copenhagen, Dept Publ Hlth, Copenhagen, Denmark.
   [Oei, Nicole Y. L.] Univ Amsterdam, Dev Psychol ADAPT Lab, NL-1018 XA Amsterdam, Netherlands.
   [Oei, Nicole Y. L.] Univ Amsterdam, Amsterdam Brain & Cognit, NL-1018 XA Amsterdam, Netherlands.
C3 Leiden University; Leiden University Medical Center (LUMC); Leiden
   University - Excl LUMC; Leiden University - Excl LUMC; Leiden
   University; Leiden University Medical Center (LUMC); University of
   Copenhagen; University of Amsterdam; University of Amsterdam
RP Oei, NYL (corresponding author), Univ Amsterdam, Dept Dev Psychol, Amsterdam Brain & Cognit, ADAPT Lab, Weesperpl 4, NL-1018 XA Amsterdam, Netherlands.
EM noei@xs4all.nl
RI Oei, Nicole/T-1219-2019
OI van der Grond, Jeroen/0000-0002-0185-3158
FU European Commission project Switchbox [Health-F2-2010-259772]; Amsterdam
   Brain and Cognition Center (University of Amsterdam)
FX The authors report no conflicts of interest. The authors are solely
   responsible for the content and writing of this article. This project
   was financially supported by the European Commission project Switchbox
   (FP7, Health-F2-2010-259772). N.O. is funded by a Talent grant from
   Amsterdam Brain and Cognition Center (University of Amsterdam).
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NR 51
TC 5
Z9 5
U1 0
U2 11
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1025-3890
EI 1607-8888
J9 STRESS
JI Stress
PD JAN 2
PY 2016
VL 19
IS 1
BP 28
EP 36
DI 10.3109/10253890.2015.1105213
PG 9
WC Behavioral Sciences; Endocrinology & Metabolism; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Behavioral Sciences; Endocrinology & Metabolism; Neurosciences &
   Neurology
GA DB7JS
UT WOS:000368691800004
PM 26453529
OA Green Published
DA 2025-06-11
ER

PT J
AU Zhang, L
AF Zhang, Le
TI Protective Effect of Tertiary Butylhydroquinone against Obesity-induced
   Skeletal Muscle Pathology in Post-weaning High Fat Diet Fed Rats
SO CURRENT PHARMACEUTICAL BIOTECHNOLOGY
LA English
DT Article
DE Obesity; metabolic syndrome; insulin resistance; dysdipidaemia;
   polyphenol; tert-butylhydroquinone (tBHQ)
ID EXTRACT; METABOLISM; INSULIN; PROFILE; LEPTIN; PLASMA; LIPASE; ALPHA;
   LIVER
AB Background Obesity deleteriously affects skeletal muscle functionality starting from infancy to adulthood, leading to dysfunctional skeletal muscle.Objectives This study, therefore, evaluated the protective action of tert-butylhydroquinone (tBHQ) against obesity-induced skeletal muscle pathology in high-fat diet (HFD) fed rats.Methods Twenty post-weaning male albino rats were randomized into four groups of five rats each as: Group 1 (control), Group 2 (HFD), Group 3 (orlistat) and Group 4 (tBHQ). Group one received rat pellets for 12 weeks, while groups 2 to 4 received HFD for 12 weeks. At the end of week 8, obesity was confirmed with Lee Obesity Index and body mass index values of >= 303 and >= 0.68 gcm2, respectively. Group 3 was given oral administration of orlistat (10 mg/kg, once daily), while group 4 was given oral administration of tBHQ (25 mg/kg, once daily). Administration of orlistat and tBHQ commenced from week 9 to the end of the experiment.Results Chronic exposure of post-weaning rats to HFD led to their development of the metabolic syndrome phenotypes in adulthood, characterized by obesity, hyperglycemia, dyslipidaemia, hyperinsulinaemia, insulin resistance as well as induction of oxidative stress and alteration of skeletal muscle markers, which were mitigated following supplementation with orlistat and tBHQ.Conclusion The study showed the anti-obesity potentials of tBHQ and its protective action against HFD obesity-induced skeletal muscular pathology.
C1 [Zhang, Le] Hanzhong Cent Hosp, Dept Pediat, Hanzhong 723000, Peoples R China.
RP Zhang, L (corresponding author), Hanzhong Cent Hosp, Dept Pediat, Hanzhong 723000, Peoples R China.
EM zhangle0950@outlook.com
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NR 62
TC 0
Z9 0
U1 2
U2 3
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1389-2010
EI 1873-4316
J9 CURR PHARM BIOTECHNO
JI Curr. Pharm. Biotechnol.
PY 2024
VL 25
IS 10
BP 1276
EP 1287
DI 10.2174/1389201024666230810094809
PG 12
WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
GA RW7P9
UT WOS:001230765500004
PM 37565558
DA 2025-06-11
ER

PT J
AU Sicari, V
   Romeo, R
   Mincione, A
   Santacaterina, S
   Tundis, R
   Loizzo, MR
AF Sicari, Vincenzo
   Romeo, Rosa
   Mincione, Antonio
   Santacaterina, Simone
   Tundis, Rosa
   Loizzo, Monica Rosa
TI Ciabatta Bread Incorporating Goji (Lycium barbarum L.): A New
   Potential Functional Product with Impact on Human Health
SO FOODS
LA English
DT Article
DE Lycium barbarum; phytochemical content; antioxidant activity; lipase
   inhibition; alpha-amylase inhibition; alpha-glucosidase inhibition;
   consumer's acceptance
ID METABOLIC SYNDROME; OXIDATIVE STRESS; ANTIOXIDANT; CONSTITUENTS;
   PROFILE; POMACE; BERRY
AB This work investigated the phytochemical content and bioactivity of Lycium barbarum collected in Calabria and evaluated, for the first time, the possibility of enriching traditional ciabatta bread with goji fresh flesh puree. For this purpose, goji flesh puree, bread, and bread enriched with 20% and 40% goji flesh puree (G20 and G40 samples, respectively) were subjected to several analyses. Selected compounds were quantified by UHPLC analysis in both goji fresh flesh puree and after simulation of the cooking process. The impact of the addition on key enzymes (lipase, alpha-amylase, and alpha-glucosidase) related to metabolic syndrome was assessed together with the antioxidant properties. Texture, colourimetric, and sensory analyses on enriched bread were performed to evaluate consumer acceptance. Despite cooking, the enriched bread maintained good levels of bioactive compounds compared to the berry pulp alone (p < 0.01). The enriched bread showed the ability to protect against lipid peroxidation, with IC50 values of 6.88 and 6.52 mu g/mL for samples G20 and G40, respectively, after incubation for 30 min (p < 0.01). Although less active than the control, the enriched bread showed inhibitory activities against the enzymes involved in the digestion of carbohydrates. From a sensory point of view, the addition of goji fresh pulp puree slightly modified the appearance but not the flavour and taste of the bread. Collectively, our results support the potential healthy function of this baked product.
C1 [Sicari, Vincenzo; Romeo, Rosa; Mincione, Antonio; Santacaterina, Simone] Mediterranea Univ Reggio Calabria, Dept Agr, I-89122 Reggio Di Calabria, Italy.
   [Tundis, Rosa; Loizzo, Monica Rosa] Univ Calabria, Dept Pharm Hlth & Nutr Sci, I-87036 Arcavacata Di Rende, Italy.
C3 Universita Mediterranea di Reggio Calabria; University of Calabria
RP Tundis, R (corresponding author), Univ Calabria, Dept Pharm Hlth & Nutr Sci, I-87036 Arcavacata Di Rende, Italy.
EM rosa.tundis@unical.it
RI ; Mincione, Antonio/C-1408-2018
OI Loizzo, Monica Rosa/0000-0002-6050-9357; Romeo,
   Rosa/0000-0002-1077-9316; Vincenzo, Sicari/0000-0001-7550-9571;
   Mincione, Antonio/0000-0001-5828-098X; Tundis, Rosa/0000-0002-3713-4403
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NR 57
TC 11
Z9 11
U1 3
U2 12
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2304-8158
J9 FOODS
JI Foods
PD FEB
PY 2023
VL 12
IS 3
AR 566
DI 10.3390/foods12030566
PG 17
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA 9C9AA
UT WOS:000935700000001
PM 36766094
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Ghassemi, M
   Hosseinchi, S
   Seirafianpour, F
   Dodangeh, M
   Goodarzi, A
AF Ghassemi, Mohammadreza
   Hosseinchi, Saba
   Seirafianpour, Farnoosh
   Dodangeh, Milad
   Goodarzi, Azadeh
TI Non-alcoholic fatty liver and lipid profile status in patients with
   melasma: A case-control study
SO JOURNAL OF COSMETIC DERMATOLOGY
LA English
DT Article
DE case&#8208; control study; fatty liver; hyperpigmented; lipid; lipid
   profile; liver enzymes; low&#8208; density lipoprotein; melasma;
   metabolic syndrome
ID OXIDATIVE STRESS PARAMETERS; TRANEXAMIC ACID; MARKERS; HYDROQUINONE;
   ANTIOXIDANTS; PEROXIDATION; MELANOCYTE; EFFICACY; WOMEN; SKIN
AB Background There are pieces of evidence regarding the association between melasma and metabolic syndrome. To assess the prevalence and grade of nonalcoholic fatty liver and lipid profile status in patients with melasma, we designed this case-control study.
   Methods This study was performed on 30 consecutive women with melasma who referred to the dermatology clinic of the hospital as the case group and 34 healthy women. For all participants, serum lipid profiles and liver enzymes were checked. Also, the existence of fatty liver was assessed by ultrasonography.
   Results Except for serum level of LDL (low-density lipoprotein) that was significantly higher in the melasma group than in the healthy group (104.23 +/- 25.00 mg/dl versus 89.85 +/- 23.00 mg/dl, p = 0.020), the level of other parameters including other lipid profiles, blood sugar, or liver enzymes was similar in both groups. In ultrasonography, the overall prevalence of fatty liver was 23.3% in the melasma group and 20.6% in the control group, and no difference was found between the two groups in grade of fatty liver (p = 0.791).
   Conclusion The study showed a higher serum LDL level in patients with melasma compared to women without melasma, but there was no difference between the groups in prevalence or grade of fatty liver.
C1 [Ghassemi, Mohammadreza; Goodarzi, Azadeh] Iran Univ Med Sci IUMS, Dept Dermatol, Rasool Akram Med Complex,Niayesh St, Tehran, Iran.
   [Hosseinchi, Saba] Iran Univ Med Sci IUMS, Tehran, Iran.
   [Seirafianpour, Farnoosh; Dodangeh, Milad] Iran Univ Med Sci IUMS, Sch Med, Student Res Comm, Tehran, Iran.
C3 Iran University of Medical Sciences; Iran University of Medical
   Sciences; Iran University of Medical Sciences
RP Goodarzi, A (corresponding author), Iran Univ Med Sci IUMS, Dept Dermatol, Rasool Akram Med Complex,Niayesh St, Tehran, Iran.
EM goodarzi.a@iums.ac.ir
RI Dodangeh, Milad/AAT-9046-2020; seirafianpour, farnoosh/AAT-3885-2020;
   goodarzi, Azadeh/Z-1736-2018; Ghassemi, Mohammadreza/Z-2080-2018
OI Seirafianpour, Farnoosh/0000-0003-3794-6206; goodarzi,
   azadeh/0000-0002-1249-4429; Dodangeh, Milad/0000-0001-6974-7346
CR Abdel-Malek Z, 2000, PIGM CELL RES, V13, P156, DOI 10.1034/j.1600-0749.13.s8.28.x
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NR 38
TC 8
Z9 8
U1 0
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1473-2130
EI 1473-2165
J9 J COSMET DERMATOL-US
JI J. Cosmet. Dermatol.
PD NOV
PY 2021
VL 20
IS 11
BP 3656
EP 3660
DI 10.1111/jocd.14014
EA MAR 2021
PG 5
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA WP2ST
UT WOS:000624039500001
PM 33609335
DA 2025-06-11
ER

PT J
AU Laskowski, D
   Sjunnesson, Y
   Humblot, P
   Sirard, MA
   Andersson, G
   Gustafsson, H
   Båge, R
AF Laskowski, Denise
   Sjunnesson, Ylva
   Humblot, Patrice
   Sirard, Marc-Andre
   Andersson, Goran
   Gustafsson, Hans
   Bage, Renee
TI Insulin exposure during in vitro bovine oocyte maturation changes
   blastocyst gene expression and developmental potential
SO REPRODUCTION FERTILITY AND DEVELOPMENT
LA English
DT Article
DE dairy cow; embryo; metabolism; metabolic programming; metabolic
   syndrome; morphology; subfertility; transcriptome
ID EMBRYO DEVELOPMENT; REPRODUCTIVE FUNCTION; GROWTH-HORMONE; PREGNANCY
   RATE; 1ST CLEAVAGE; GLUCOSE; IMPACT; MOUSE; CONSEQUENCES; METABOLISM
AB Metabolic imbalance impairs fertility, because changes in concentrations of metabolites and hormones in the blood and follicular fluid create an unfavourable environment for early embryonic development. Insulin is a key metabolic hormone known for its effects on fertility: insulin concentrations are increased during energy balance disturbances in diabetes or metabolic syndrome. Still, insulin is frequently used at supraphysiological concentrations for embryo in vitro culture with unknown consequences for the developmental potential of the offspring. In the present study we investigated the effects of insulin exposure during in vitro bovine oocyte maturation on developmental rates, embryo quality and gene expression. Supplementation of the maturation media with insulin at 10 or 0.1 mu gmL(-1) decreased blastocyst rates compared with an insulin-free control (19.8 +/- 1.3% and 20.4 +/- 1.3% vs 23.8 +/- 1.3%, respectively; P<0.05) and led to increased cell numbers (nearly 10% more cells on Day 8 compared with control; P<0.05). Transcriptome analysis revealed significant upregulation of genes involved in lipid metabolism, nuclear factor (erythroid-derived 2)-like 2 (NRF2) stress response and cell differentiation, validated by quantitative polymerase chain reaction. To conclude, the results of the present study demonstrate that insulin exposure during in vitro oocyte maturation has a lasting effect on the embryo until the blastocyst stage, with a potential negative effect in the form of specific gene expression perturbations.
C1 [Laskowski, Denise; Sjunnesson, Ylva; Humblot, Patrice; Gustafsson, Hans; Bage, Renee] Swedish Univ Agr Sci, Dept Clin Sci, POB 7054, SE-75007 Uppsala, Sweden.
   [Sirard, Marc-Andre] Univ Laval, Ctr Rech Biol Reprod, Dept Sci Anim, Pavillon Serv,Local 2732, Quebec City, PQ G1V 0A6, Canada.
   [Andersson, Goran] Swedish Univ Agr Sci, Dept Anim Breeding & Genet, POB 7054, SE-75007 Uppsala, Sweden.
C3 Swedish University of Agricultural Sciences; Laval University; Swedish
   University of Agricultural Sciences
RP Laskowski, D (corresponding author), Swedish Univ Agr Sci, Dept Clin Sci, POB 7054, SE-75007 Uppsala, Sweden.
EM denise.laskowski@slu.se
RI Andersson, Goran/AAK-6564-2020; Sirard, Marc/A-9112-2011; Sjunnesson,
   Ylva/AAN-6152-2020; Humblot, Patrice/C-3876-2018; Bage,
   Renee/C-7049-2016
OI Bage, Renee/0000-0003-1413-6913; Sirard, Marc Andre/0000-0001-8667-6682;
   Sjunnesson, Ylva/0000-0003-4500-5123
FU FORMAS, The Swedish Research Council for Environment, Agricultural
   Sciences and Spatial Planning [222-2010-1132]; Natural Sciences and
   Engineering Research Council of Canada (NSERC) Canada
FX The authors acknowledge Isabelle Dufort, Dominic Gagne and Eric Fournier
   at EmbryoGENE for their support in the laboratory and bioinformatics
   work, and Maria Celina Abraham and Ida Lindgren for their help in the
   IVF laboratory in SLU, Uppsala. The authors also thank SCAN (Linkoping,
   Sweden) for providing the ovaries for the present study.
   Acknowledgements to Jeanette Axelsson for valuable input during the
   project proposal writing and planning. This work was supported by
   FORMAS, The Swedish Research Council for Environment, Agricultural
   Sciences and Spatial Planning (Grant no. 222-2010-1132). Collaboration
   with EmbryoGENE was supported by The Natural Sciences and Engineering
   Research Council of Canada (NSERC) Canada.
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NR 75
TC 15
Z9 18
U1 0
U2 9
PU CSIRO PUBLISHING
PI CLAYTON
PA UNIPARK, BLDG 1, LEVEL 1, 195 WELLINGTON RD, LOCKED BAG 10, CLAYTON, VIC
   3168, AUSTRALIA
SN 1031-3613
EI 1448-5990
J9 REPROD FERT DEVELOP
JI Reprod. Fertil. Dev.
PD APR
PY 2017
VL 29
IS 5
BP 876
EP 889
DI 10.1071/RD15315
PG 14
WC Developmental Biology; Reproductive Biology; Zoology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Developmental Biology; Reproductive Biology; Zoology
GA ES1TI
UT WOS:000399309500004
PM 26922243
OA hybrid, Green Submitted
DA 2025-06-11
ER

PT J
AU Park, JS
   Kang, SA
   Yoo, JS
   Ahn, CW
   Cha, BS
   Kim, KR
   Lee, HC
AF Park, Jong Suk
   Kang, Sin Ae
   Yoo, Jeong Seon
   Ahn, Chul Woo
   Cha, Bong Soo
   Kim, Kyung Rae
   Lee, Hyun Chul
TI Association between γ-Glutamyltransferase, Adiponectin and Arterial
   Stiffness
SO JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
LA English
DT Article
DE gamma-Glutamyltransferase; Adiponectin; Pulse wave velocity
ID PULSE-WAVE VELOCITY; METABOLIC SYNDROME; CARDIOVASCULAR-DISEASE; KOREAN
   POPULATION; OXIDATIVE STRESS; YOUNG-ADULTS; RISK; LEVEL; MEN;
   GLUTAMYLTRANSFERASE
AB Aim: Serum gamma-glutamyltransferase (GGT) is used as a marker of hepatic dysfunction. Recently, several studies reported that GGT is significantly associated with cardiovascular mortality and atherosclerosis. Adiponectin is known to play an important role in the development of atherosclerosis, but its physiologic role has yet to be fully determined. In this study, we investigated the relationships among serum GGT, adiponectin and arterial stiffness.
   Methods: Of 4236 subjects recruited from 17 different medical centers in Seoul, Korea, 2846 subjects were enrolled in our study. The parameters of metabolic syndrome (MetS) were assessed in these subjects, and their plasma adiponectin levels and pulse wave velocity (PWV) were measured along with anthropometric and biochemical profiles, including GGT.
   Results: The subjects were stratified into 3 groups according to GGT values. PWV values gradually increased and the adiponectin level decreased with GGT tertiles. Aortic PWV showed a significant correlation with age, SBP, FPG, but there was no correlation among aortic PWV, GGT and adiponectin. Peripheral PWV demonstrated a significant correlation with age, SBP, DBP, BMI, WC, FPG and GGT, but there was no correlation between peripheral PWV and adiponectin. In multiple logistic regression analysis after adjusting for risk factors, GGT was a significant contributor to increased peripheral PWV.
   Conclusions: These findings indicate that serum GGT is independently associated with increased arterial stiffness, but there was no correlation between adiponectin and arterial stiffness in both males and females.
C1 [Park, Jong Suk; Kang, Sin Ae; Yoo, Jeong Seon; Ahn, Chul Woo; Cha, Bong Soo; Kim, Kyung Rae; Lee, Hyun Chul] Yonsei Univ, Coll Med, Dept Internal Med, Seoul, South Korea.
   [Park, Jong Suk; Ahn, Chul Woo] Yonsei Univ, Coll Med, Severance Inst Vasc & Metab Res, Seoul, South Korea.
C3 Yonsei University; Yonsei University Health System; Yonsei University;
   Yonsei University Health System
RP Ahn, CW (corresponding author), Yonsei Univ, Coll Med, Div Endocrinol, Kangnam Severance Hosp,Dept Internal Med, 146-92 Dogok Dong, Seoul, South Korea.
EM acw@yuhs.ac
RI Lee, YoungMi/JCF-0461-2023
OI Yoo, Jeongseon/0000-0002-4897-3712; Ahn, Chul Woo/0000-0003-3733-7486
FU Seoul R&BD Program, Republic of Korea [10526]
FX This study was supported by a grant from the Seoul R&BD Program,
   Republic of Korea (10526).
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NR 39
TC 16
Z9 18
U1 0
U2 2
PU JAPAN ATHEROSCLEROSIS SOC
PI TOKYO
PA NICHINAI-KAIKAN B1, 3-28-8 HONGO BUNKYO-KU, TOKYO, 113-0033, JAPAN
SN 1340-3478
EI 1880-3873
J9 J ATHEROSCLER THROMB
JI J. Atheroscler. Thromb.
PY 2012
VL 19
IS 1
BP 90
EP 97
DI 10.5551/jat.9779
PG 8
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 893AU
UT WOS:000300328200009
PM 21986103
OA hybrid
DA 2025-06-11
ER

PT J
AU Raberin, A
   Connes, P
   Barthélémy, JC
   Robert, P
   Celle, S
   Hupin, D
   Faes, C
   Rytz, C
   Roche, F
   Pialoux, V
AF Raberin, Antoine
   Connes, Philippe
   Barthelemy, Jean Claude
   Robert, Pia
   Celle, Sebastien
   Hupin, David
   Faes, Camille
   Rytz, Chantal
   Roche, Frederic
   Pialoux, Vincent
TI Role of Gender and Physical Activity Level on Cardiovascular Risk
   Factors and Biomarkers of Oxidative Stress in the Elderly
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Article
ID ALL-CAUSE MORTALITY; METABOLIC SYNDROME; EUROPEAN MEN; HEART;
   PREVALENCE; DISEASE; WOMEN; POPULATION; PROTECTION; MORBIDITY
AB Cardiovascular diseases remain as the leading cause of morbidity and mortality in industrialized countries. Ageing and gender strongly modulate the risk to develop cardiovascular diseases but very few studies have investigated the impact of gender on cardiovascular diseases in the elderly, which represents a growing population. The purpose of this study was to test the impact of gender and physical activity level on several biochemical and clinical markers of cardiovascular risk in elderly individuals. Methods. Elderly individuals (318 women (75.8 +/- 1.2 years-old) and 227 men (75.8 +/- 1.1 years-old)) were recruited. Physical activity was measured by a questionnaire. Metabolic syndrome was defined using the National Cholesterol Education Program Expert Panel's definition. Polysomnography and digital tonometry were used to detect obstructive sleep apnea and assess vascular reactivity, respectively. Blood was sampled to measure several oxidative stress markers and adhesion molecules. Results. The frequency of cardiovascular diseases was significantly higher in men (16.4%) than in women (6.1%) (p < 0.001). Body mass index (25.0 +/- 4.3 vs. 25.8 +/- 3.13 kg.m(-2)) and glycaemia (94.9 +/- 16.5 vs. 101.5 +/- 22.6mg.dL(-1)) were lower, and High Density Lipoprotein (HDL) (74.6 +/- 17.8 vs. 65.0 +/- 17.2mg.dL(-1)) was higher in women compared to men (p < 0.05). Oxidative stress was lower in women than in men (uric acid. 52.05 +/- 13.78 vs. 59.84 +/- 13.58, advanced oxidation protein products. 223 +/- 94 vs. 246 +/- 101 mu mol.L-1, malondialdehyde. 22.44 +/- 6.81 vs. 23.88 +/- 9.74 nmol.L-1). Physical activity was not associated with lower cardiovascular risk factors in both genders. Multivariate analyses showed an independent effect of gender on acid uric (beta = 0.182; p = 0.020), advanced oxidation protein products (beta = 0.257; p < 0.001), and HDL concentration (beta = -0.182; p = 0.026). Conclusion. These findings suggest that biochemical cardiovascular risk factors are lower in women than men which could explain the lower cardiovascular disease proportion observed in women in the elderly.
C1 [Raberin, Antoine; Connes, Philippe; Robert, Pia; Faes, Camille; Pialoux, Vincent] Univ Claude Bernard Lyon 1, Univ Lyon, Team & Vasc Biol & Red Blood Cell, Lab Interuniv Biol Motricite LIBM EA7424, Villeurbanne, France.
   [Raberin, Antoine; Connes, Philippe; Robert, Pia; Faes, Camille; Pialoux, Vincent] PRES Sorbonne, Lab Excellence Globule Rouge Labex GR Ex, Paris, France.
   [Connes, Philippe; Pialoux, Vincent] Inst Univ France, Paris, France.
   [Barthelemy, Jean Claude; Celle, Sebastien; Hupin, David; Roche, Frederic] Univ Jean Monnet, Univ Lyon, Fac Med Jacques Lisfranc, Serv Physiol Clin & Exercice, St Etienne, France.
   [Barthelemy, Jean Claude; Celle, Sebastien; Hupin, David; Roche, Frederic] Univ Jean Monnet, Univ Lyon, Lab Syst Nerveux Autonome Epidemiol, Physiol,Ingn,Sante,EA SNA EPIS 4607, St Etienne, France.
   [Rytz, Chantal] Univ Calgary, Cumming Sch Med, Dept Physiol & Pharmacol, Calgary, AB, Canada.
C3 Universite Claude Bernard Lyon 1; Institut National de la Sante et de la
   Recherche Medicale (Inserm); Institut National de la Sante et de la
   Recherche Medicale (Inserm); Institut Universitaire de France;
   University of Calgary
RP Pialoux, V (corresponding author), Univ Claude Bernard Lyon 1, Univ Lyon, Team & Vasc Biol & Red Blood Cell, Lab Interuniv Biol Motricite LIBM EA7424, Villeurbanne, France.; Pialoux, V (corresponding author), PRES Sorbonne, Lab Excellence Globule Rouge Labex GR Ex, Paris, France.; Pialoux, V (corresponding author), Inst Univ France, Paris, France.
EM vincent.pialoux@univ-lyon1.fr
RI Connes, Philippe/J-7835-2019; Barthelemy, Jean-Claude/AAE-7180-2019;
   Raberin, Antoine/IYS-9077-2023
OI pialoux, vincent/0000-0003-2057-061X; Roche,
   Frederic/0000-0001-6115-7958; Barthelemy,
   Jean-Claude/0000-0003-4306-7275; Rytz, Chantal/0000-0001-5174-6708;
   FAES, Camille/0000-0001-7047-2482; Raberin, Antoine/0000-0001-5032-8301;
   Connes, Philippe/0000-0002-9232-0268
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NR 43
TC 9
Z9 12
U1 0
U2 3
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PD JUN 19
PY 2020
VL 2020
AR 1315471
DI 10.1155/2020/1315471
PG 9
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA MG6LC
UT WOS:000546140100001
PM 32655757
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Talarico, CHZ
   Alves, ES
   Dos Santos, JDM
   Sucupira, FGS
   Araujo, LCC
   Camporez, JP
AF Talarico, Carlos H. Z.
   Alves, Ester S.
   Dos Santos, Jessica D. M.
   Sucupira, Felipe G. S.
   Araujo, Layanne C. C.
   Camporez, Joao Paulo
TI Progesterone Has No Impact on the Beneficial Effects of Estradiol
   Treatment in High-Fat-Fed Ovariectomized Mice
SO CURRENT ISSUES IN MOLECULAR BIOLOGY
LA English
DT Article
DE menopause; ovariectomy glucose metabolism; metabolic syndrome
ID IMPROVES INSULIN SENSITIVITY; REPLACEMENT THERAPY; CELLULAR MECHANISM;
   LIVER-DISEASE; RESISTANCE; DIET; MENOPAUSE; PROTECTS; OBESITY; STRESS
AB In recent decades, clinical and experimental studies have revealed that estradiol contributes enormously to glycemic homeostasis. However, the same consensus does not exist in women during menopause who undergo replacement with progesterone or conjugated estradiol and progesterone. Since most hormone replacement treatments in menopausal women are performed with estradiol (E2) and progesterone (P4) combined, this work aimed to investigate the effects of progesterone on energy metabolism and insulin resistance in an experimental model of menopause (ovariectomized female mice-OVX mice) fed a high-fat diet (HFD). OVX mice were treated with E2 or P4 (or both combined). OVX mice treated with E2 alone or combined with P4 displayed reduced body weight after six weeks of HFD feeding compared to OVX mice and OVX mice treated with P4 alone. These data were associated with improved glucose tolerance and insulin sensitivity in OVX mice treated with E2 (alone or combined with P4) compared to OVX and P4-treated mice. Additionally, E2 treatment (alone or combined with P4) reduced both hepatic and muscle triglyceride content compared with OVX control mice and OVX + P4 mice. There were no differences between groups regarding hepatic enzymes in plasma and inflammatory markers. Therefore, our results revealed that progesterone replacement alone does not seem to influence glucose homeostasis and ectopic lipid accumulation in OVX mice. These results will help expand knowledge about hormone replacement in postmenopausal women associated with metabolic syndrome and non-alcoholic fatty liver disease.
C1 [Talarico, Carlos H. Z.; Alves, Ester S.; Dos Santos, Jessica D. M.; Sucupira, Felipe G. S.; Araujo, Layanne C. C.; Camporez, Joao Paulo] Univ Sao Paulo, Ribeirao Preto Sch Med, Dept Physiol, BR-14049900 Ribeirao Preto, Brazil.
C3 Universidade de Sao Paulo
RP Camporez, JP (corresponding author), Univ Sao Paulo, Ribeirao Preto Sch Med, Dept Physiol, BR-14049900 Ribeirao Preto, Brazil.
EM camporez@fmrp.usp.br
RI Matos dos Santos, Jessica Denielle/HME-2735-2023; Camporez,
   Joao/B-9122-2015
OI Zanello, Carlos/0000-0002-3150-4565; Dos Santos Alves,
   Ester/0000-0002-0657-561X; Camporez, Joao Paulo/0000-0003-3486-4301;
   Matos dos Santos, Jessica Denielle/0000-0002-7950-3617; Sucupira,
   Felipe/0000-0002-0604-5715
FU Sao Paulo Research Foundation (FAPESP) [2018/04956-5, 2020/09094-1,
   2020/16160-0, 2021/02638-9]
FX This work was supported by the Sao Paulo Research Foundation (FAPESP,
   2018/04956-5, 2020/09094-1, 2020/16160-0, 2021/02638-9).
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NR 53
TC 3
Z9 3
U1 2
U2 5
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1467-3037
EI 1467-3045
J9 CURR ISSUES MOL BIOL
JI Curr. Issues Mol. Biol.
PD MAY 3
PY 2023
VL 45
IS 5
BP 3965
EP 3976
DI 10.3390/cimb45050253
PG 12
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA K7AQ5
UT WOS:001017935200001
PM 37232722
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Khoshandam, A
   Hedayatian, A
   Mollazadeh, A
   Razavi, BM
   Hosseinzadeh, H
AF Khoshandam, Arian
   Hedayatian, AmirHossein
   Mollazadeh, AmirReza
   Razavi, Bibi Marjan
   Hosseinzadeh, Hossein
TI Propolis and its constituents against cardiovascular risk factors
   including obesity, hypertension, atherosclerosis, diabetes, and
   dyslipidemia: A comprehensive review
SO IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
LA English
DT Review
DE Atherosclerosis; Cardiovascular disease; Diabetes; Dyslipidemia;
   Hypertension; Obesity; Propolis
ID ACID PHENETHYL ESTER; BRAZILIAN GREEN PROPOLIS; DIET-INDUCED OBESITY;
   METABOLIC SYNDROME; OXIDATIVE STRESS; DOUBLE-BLIND;
   BIOLOGICAL-ACTIVITIES; INSULIN-RESISTANCE; CHINESE PROPOLIS; MAJOR
   COMPONENT
AB Cardiovascular diseases (CVDs) are some of the major causes of death worldwide. The modern lifestyle elevates the risk of CVDs. CVDs have several risk factors such as obesity, dyslipidemia, atherosclerosis, hypertension, and diabetes. Using herbal and natural products plays a pivotal role in the treatment of different diseases such as CVDs, diabetes, and metabolic syndrome. Propolis, a natural resinous mixture, is made by honey bees. Its main components are phenolics and terpenoid compounds such as caffeic acid phenethyl ester, chrysin, and quercetin. In this review, multiple studies regarding the pharmacological impacts of propolis and its constituents with their related mechanisms of action against mentioned CVD risk factors have been discussed in detail. Here, we used electronic databases or search engines such as Scopus, Web of Science, Pubmed, and Google Scholar without time limitations. The primary components of propolis are phenolics and terpenoid compounds such as caffeic acid phenethyl ester, chrysin and quercetin. Propolis and its constituents have been found to exhibit anti-obesity, anti-hypertension, anti-dyslipidemic, anti-atherosclerosis, and anti-diabetic effects. The vast majority of studies discussed in this review demonstrate that propolis and its constituents could have therapeutic effects against mentioned CVD risk factors via several mechanisms such as antioxidant, anti-inflammatory, reducing adipogenesis, HMG-CoA reductase inhibitory effect, inhibition of the ACE, increasing insulin secretion, NO level, etc.
C1 [Khoshandam, Arian; Hedayatian, AmirHossein; Mollazadeh, AmirReza] Mashhad Univ Med Sci, Sch Pharm, Mashhad, Iran.
   [Razavi, Bibi Marjan] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Targeted Drug Delivery Res Ctr, Mashhad, Iran.
   [Razavi, Bibi Marjan; Hosseinzadeh, Hossein] Mashhad Univ Med Sci, Sch Pharm, Dept Pharmacodynam & Toxicol, Mashhad, Iran.
   [Hosseinzadeh, Hossein] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Pharmaceut Res Ctr, Mashhad, Iran.
C3 Mashhad University of Medical Sciences; Mashhad University of Medical
   Sciences; Mashhad University of Medical Sciences; Mashhad University of
   Medical Sciences
RP Hosseinzadeh, H (corresponding author), Mashhad Univ Med Sci, Sch Pharm, Dept Pharmacodynam & Toxicol, Mashhad, Iran.; Hosseinzadeh, H (corresponding author), Mashhad Univ Med Sci, Pharmaceut Technol Inst, Pharmaceut Res Ctr, Mashhad, Iran.
EM hosseinzadehh@mums.ac.ir
RI Hosseinzadeh, Hossein/F-3013-2010; Razavi, Bibi/AAY-5636-2020;
   Khoshandam, Arian/AGZ-5159-2022
OI Khoshandam, Arian/0000-0002-7316-5426
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NR 131
TC 9
Z9 9
U1 4
U2 29
PU MASHHAD UNIV MED SCIENCES
PI MASHHAD
PA VICE-CHANCELLOR FOR RES CTR OFF IJBMS, DANESHGAH ST, PO BOX 9138813944 -
   445, MASHHAD, 00000, IRAN
SN 2008-3866
EI 2008-3874
J9 IRAN J BASIC MED SCI
JI Iran. J. Basic Med. Sci.
PD MAY
PY 2023
VL 26
IS 8
BP 853
EP 871
DI 10.22038/IJBMS.2023.67793.14835
PG 19
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA O2ZX7
UT WOS:001042563900001
PM 37427329
DA 2025-06-11
ER

PT J
AU Kohli, D
   Wu, KY
   White, LJ
   Hodge, DO
   Chen, JJ
   Roddy, GW
AF Kohli, Darrell
   Wu, Kristi Y.
   White, Launia J.
   Hodge, David O.
   Chen, John J.
   Roddy, Gavin W.
TI Metabolic syndrome and its components are associated with non-arteritic
   anterior ischaemic optic neuropathy
SO BMJ OPEN OPHTHALMOLOGY
LA English
DT Article
ID OPEN-ANGLE GLAUCOMA; RISK-FACTORS; ADULT OBESITY; INFLAMMATION;
   PREVALENCE; STRESS
AB Purpose To determine whether metabolic syndrome (MetS) is a risk factor for various forms of optic neuropathy including non-arteritic anterior ischaemic optic neuropathy (NAION).
   Methods This population-based analysis identified patients >= 40 years of age in Olmsted County, Minnesota, USA using the Rochester Epidemiology Project 2005-2018. Patients with MetS were identified if three or more of the five standard criteria for diagnosing MetS were present: systemic hypertension, hyperglycaemia, hypertriglyceridaemia, reduced high-density lipoprotein cholesterol (hypoalphalipoproteinaemia) and central adiposity defined by increased body mass index. Charts of patients identified as having an optic neuropathy were reviewed to record specific diagnoses and compared with patients without ocular pathology other than cataract. The odds ratio (OR) of association with MetS was calculated and adjusted for age, sex and race with multivariate analysis for the various optic neuropathies.
   Results Patients with MetS were more likely to have an optic neuropathy than those without (OR 2.2, p<0.001). After adjusting for age, sex and race, the only optic neuropathy found to be significantly associated with MetS was NAION (OR 6.17, p=0.002). For patients with NAION, though each individual component of MetS was individually significantly associated with MetS, further analysis suggested that hypertriglyceridaemia, hypoalphalipoproteinaemia and hyperglycaemia were likely the key drivers in the overall significance between NAION and MetS.
   Conclusion Patients with MetS were more likely to have NAION. Further studies are needed to determine whether MetS is a modifiable risk factor for NAION.
C1 [Kohli, Darrell; Wu, Kristi Y.; Chen, John J.; Roddy, Gavin W.] Mayo Clin, Rochester, MN 55905 USA.
   [White, Launia J.; Hodge, David O.] Mayo Clin, Quantitat Hlth Sci, Jacksonville, FL 32224 USA.
   [Chen, John J.] Mayo Clin, Dept Neurol, Rochester, MN USA.
C3 Mayo Clinic; Mayo Clinic; Mayo Clinic
RP Roddy, GW (corresponding author), Mayo Clin, Rochester, MN 55905 USA.
EM roddy.gavin@mayo.edu
RI Chen, John/KQU-2986-2024
FU Mayo Foundation for Education and Research, National Eye Institute
   [EY031758]; National Institute on Aging [R33AG058738] Funding Source:
   NIH RePORTER
FX Mayo Foundation for Education and Research, National Eye Institute
   EY031758.
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TC 7
Z9 8
U1 0
U2 6
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2397-3269
J9 BMJ OPEN OPHTHALMOL
JI BMJ Open Ophthalmol.
PD OCT
PY 2022
VL 7
IS 1
AR e001111
DI 10.1136/bmjophth-2022-001111
PG 8
WC Ophthalmology
WE Emerging Sources Citation Index (ESCI)
SC Ophthalmology
GA 5C5UP
UT WOS:000864325000002
PM 36437528
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Cimini, FA
   Perluigi, M
   Barchetta, I
   Cavallo, MG
   Barone, E
AF Cimini, Flavia Agata
   Perluigi, Marzia
   Barchetta, Ilaria
   Cavallo, Maria Gisella
   Barone, Eugenio
TI Role of Biliverdin Reductase A in the Regulation of Insulin Signaling in
   Metabolic and Neurodegenerative Diseases: An Update
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE biliverdin reductase A; obesity; type 2 diabetes; Alzheimer's disease;
   dementia; insulin signaling; metabolic disorders; neurodegenerative
   diseases
ID PROTEIN-KINASE-C; MILD COGNITIVE IMPAIRMENT; GROWTH-FACTOR EXPRESSION;
   NF-KAPPA-B; ALZHEIMERS-DISEASE; INTRANASAL INSULIN; OXIDATIVE STRESS;
   MEMORY IMPAIRMENT; MAMMALIAN TARGET; HEME OXYGENASE-1
AB Insulin signaling is a conserved pathway that orchestrates glucose and lipid metabolism, energy balance, and inflammation, and its dysregulation compromises the homeostasis of multiple systems. Insulin resistance is a shared hallmark of several metabolic diseases, including obesity, metabolic syndrome, and type 2 diabetes, and has been associated with cognitive decline during aging and dementia. Numerous mechanisms promoting the development of peripheral and central insulin resistance have been described, although most of them were not completely clarified. In the last decades, several studies have highlighted that biliverdin reductase-A (BVR-A), over its canonical role in the degradation of heme, acts as a regulator of insulin signaling. Evidence from human and animal studies show that BVR-A alterations are associated with the aberrant activation of insulin signaling, metabolic syndrome, liver steatosis, and visceral adipose tissue inflammation in obese and diabetic individuals. In addition, recent findings demonstrated that reduced BVR-A levels or impaired BVR-A activation contribute to the development of brain insulin resistance and metabolic alterations in Alzheimer's disease. In this narrative review, we will provide an overview on the literature by focusing on the role of BVR-A in the regulation of insulin signaling and how BVR-A alterations impact on cell dysfunctions in both metabolic and neurodegenerative disorders.
C1 [Cimini, Flavia Agata; Barchetta, Ilaria; Cavallo, Maria Gisella] Sapienza Univ Rome, Dept Expt Med, I-00185 Rome, Italy.
   [Perluigi, Marzia; Barone, Eugenio] Sapienza Univ Rome, Dept Biochem Sci A Rossi Fanelli, I-00185 Rome, Italy.
C3 Sapienza University Rome; Sapienza University Rome
RP Cavallo, MG (corresponding author), Sapienza Univ Rome, Dept Expt Med, I-00185 Rome, Italy.
EM flaviaagata.cimini@uniroma1.it; marzia.perluigi@uniroma1.it;
   ilaria.barchetta@uniroma1.it; gisella.cavallo@uniroma1.it;
   eugenio.barone@uniroma1.it
RI Cimini, Flavia/AAC-1985-2019; Baroni, Marco Giorgio/AIA-6973-2022;
   Barone, Eugenio/AAC-1686-2019; Barchetta, Ilaria/I-3016-2019; perluigi,
   marzia/D-3260-2009
OI cavallo, maria gisella/0000-0001-6630-8049; Barone,
   Eugenio/0000-0002-7028-4251; Cimini, Flavia/0000-0001-7630-7349;
   Barchetta, Ilaria/0000-0003-0530-8568
FU Fondi Ateneo grant - Sapienza University [RG11916B87F55459,
   RM11916B811AFD26]
FX This work was supported by Fondi Ateneo grant funded by Sapienza
   University nffi RG11916B87F55459 to EB and RM11916B811AFD26 to MGC.
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NR 130
TC 12
Z9 12
U1 1
U2 8
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD MAY
PY 2022
VL 23
IS 10
AR 5574
DI 10.3390/ijms23105574
PG 19
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 1R6XP
UT WOS:000803511200001
PM 35628384
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Johnson, RJ
   Sautin, YY
   Oliver, WJ
   Roncal, C
   Mu, W
   Sanchez-Lozada, LG
   Rodriguez-Iturbe, B
   Nakagawa, T
   Benner, SA
AF Johnson, Richard J.
   Sautin, Yuri Y.
   Oliver, William J.
   Roncal, Carlos
   Mu, Wei
   Sanchez-Lozada, L. Gabriela
   Rodriguez-Iturbe, Bernardo
   Nakagawa, Takahiko
   Benner, Steven A.
TI Lessons from comparative physiology: could uric acid represent a
   physiologic alarm signal gone awry in western society?
SO JOURNAL OF COMPARATIVE PHYSIOLOGY B-BIOCHEMICAL SYSTEMS AND
   ENVIRONMENTAL PHYSIOLOGY
LA English
DT Review
DE Uric acid; Fructose; Foraging; Metabolic syndrome; Obesity; Fasting;
   Hibernation
ID EXTRACELLULAR-SUPEROXIDE DISMUTASE; BLOOD-PRESSURE; METABOLIC SYNDROME;
   PROTEIN-UTILIZATION; CELL-PROLIFERATION; OXIDATIVE STRESS; URATE
   OXIDASE; RISK-FACTOR; VITAMIN-E; FRUCTOSE
AB Uric acid has historically been viewed as a purine metabolic waste product excreted by the kidney and gut that is relatively unimportant other than its penchant to crystallize in joints to cause the disease gout. In recent years, however, there has been the realization that uric acid is not biologically inert but may have a wide range of actions, including being both a pro- and anti-oxidant, a neurostimulant, and an inducer of inflammation and activator of the innate immune response. In this paper, we present the hypothesis that uric acid has a key role in the foraging response associated with starvation and fasting. We further suggest that there is a complex interplay between fructose, uric acid and vitamin C, with fructose and uric acid stimulating the foraging response and vitamin C countering this response. Finally, we suggest that the mutations in ascorbate synthesis and uricase that characterized early primate evolution were likely in response to the need to stimulate the foraging "survival" response and might have inadvertently had a role in accelerating the development of bipedal locomotion and intellectual development. Unfortunately, due to marked changes in the diet, resulting in dramatic increases in fructose- and purine-rich foods, these identical genotypic changes may be largely responsible for the epidemic of obesity, diabetes and cardiovascular disease in today's society.
C1 [Johnson, Richard J.; Sautin, Yuri Y.; Roncal, Carlos; Mu, Wei; Nakagawa, Takahiko] Univ Florida, Div Nephrol Hypertens & Transplantat, Gainesville, FL 32610 USA.
   [Rodriguez-Iturbe, Bernardo] Univ Zulia, Maracaibo 4011, Venezuela.
   [Benner, Steven A.] Fdn Appl Mol Evolut, Gainesville, FL USA.
C3 State University System of Florida; University of Florida
RP Johnson, RJ (corresponding author), Univ Florida, Div Nephrol Hypertens & Transplantat, POB 100224, Gainesville, FL 32610 USA.
EM johnsrj@medicine.ufl.edu
RI Sanchez-Lozada, Laura/AAS-2104-2021
OI Sanchez-Lozada, Laura-Gabriela/0000-0003-0348-9617; Sautin,
   Yuri/0000-0003-3618-5134
FU US Public Health Service [HL-68607, DK-52121]
FX Supported by US Public Health Service grants HL-68607 (RJ), DK-52121
   (RJ).
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NR 97
TC 113
Z9 121
U1 1
U2 21
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0174-1578
EI 1432-136X
J9 J COMP PHYSIOL B
JI J. Comp. Physiol. B-Biochem. Syst. Environ. Physiol.
PD JAN
PY 2009
VL 179
IS 1
BP 67
EP 76
DI 10.1007/s00360-008-0291-7
PG 10
WC Physiology; Zoology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology; Zoology
GA 399VV
UT WOS:000262828300003
PM 18649082
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Pasquali, R
   Vicennati, V
   Gambineri, A
   Pagotto, U
AF Pasquali, R.
   Vicennati, V.
   Gambineri, A.
   Pagotto, U.
TI Sex-dependent role of glucocorticoids and androgens in the
   pathophysiology of human obesity
SO INTERNATIONAL JOURNAL OF OBESITY
LA English
DT Review
DE cortisol; androgens; males; females
ID HORMONE-BINDING-GLOBULIN; PITUITARY-ADRENAL AXIS;
   POLYCYSTIC-OVARY-SYNDROME; BODY-FAT DISTRIBUTION; 11-BETA-HYDROXYSTEROID
   DEHYDROGENASE TYPE-1; PLASMA-CORTISOL LEVELS; METABOLIC-CLEARANCE RATES;
   INSULIN-RESISTANCE; ABDOMINAL OBESITY; POSTMENOPAUSAL WOMEN
AB Obesity, particularly its abdominal phenotype, a harbinger of the metabolic syndrome, cardiovascular diseases (CVDs) and type 2 diabetes mellitus (T2D), is becoming one of the most significant public health problems worldwide. Among many other potential factors, derangement of multiple hormone systems have increasingly been considered for their potential importance in the pathophysiology of obesity and the metabolic syndrome, with particular reference to glucocorticoids and sex hormones. These systems have a fundamental and coordinating role in the physiology of intermediate metabolism and cardiovascular function, and in the response to acute and chronic stress challenge. Abdominal obesity is associated with a hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis and impaired androgen balance, although these alterations differ according to sex. As there is also increasing evidence that there are many differences between the sexes in the susceptibility and development of obesity, T2D and CVDs, we support the hypothesis that alterations of the HPA axis and androgen balance may have an important function in this context. This is further supported by the fact that there are important differences between males and females in their ability to adapt to both internal and particularly to environmental (external) stressors. In addition, there is also evidence that, in both physiological and pathological conditions, a close cross talk exists between sex hormones and glucocorticoids at both neuroendocrine and peripheral level, again with different specificities according to sex.
C1 [Pasquali, R.; Vicennati, V.; Gambineri, A.; Pagotto, U.] Univ Alma Mater Studiorum, Div Endocrinol, Dept Internal Med, S Orsola M Malpighi Hosp, I-40138 Bologna, Italy.
C3 IRCCS Azienda Ospedaliero-Universitaria di Bologna; University of
   Bologna
RP Pasquali, R (corresponding author), Univ Alma Mater Studiorum, Div Endocrinol, Dept Internal Med, S Orsola M Malpighi Hosp, Via Massarenti 9, I-40138 Bologna, Italy.
EM renato.pasquali@unibo.it
RI Vicennati, Valentina/AAB-3291-2022
OI Vicennati, Valentina/0000-0002-0026-137X; GAMBINERI,
   ALESSANDRA/0000-0003-2242-6734
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NR 139
TC 64
Z9 75
U1 0
U2 3
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0307-0565
EI 1476-5497
J9 INT J OBESITY
JI Int. J. Obes.
PD DEC
PY 2008
VL 32
IS 12
BP 1764
EP 1779
DI 10.1038/ijo.2008.129
PG 16
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 383TC
UT WOS:000261695400003
PM 18838976
DA 2025-06-11
ER

PT J
AU Rampengan, DDCH
   Syahputra, RA
   Halim, P
   Kumalawati, DA
   Ramadhan, RN
   Surya, R
   Wiyarta, E
   Permatasari, HK
   Tjandrawinata, RR
   Taslim, NA
   Kim, B
   Tallei, TE
   Tsopmo, A
   Nurkolis, F
AF Rampengan, Derren David Christian Homenta
   Syahputra, Rony Abdi
   Halim, Princella
   Kumalawati, Dian Aruni
   Ramadhan, Roy Novri
   Surya, Reggie
   Wiyarta, Elvan
   Permatasari, Happy Kurnia
   Tjandrawinata, Raymond Rubianto
   Taslim, Nurpudji Astuti
   Kim, Bonglee
   Tallei, Trina Ekawati
   Tsopmo, Apollinaire
   Nurkolis, Fahrul
TI Red ginger confers antioxidant activity, inhibits lipid and sugar
   metabolic enzymes, and downregulates miR-21/132 expression
SO JOURNAL OF AGRICULTURE AND FOOD RESEARCH
LA English
DT Article
DE Antidiabetes; Antiobesity; antioxidant; Metabolic syndrome; Molecular
   mechanism; red ginger
ID OFFICINALE; PEROXIDATION; EXTRACTS; CELLS
AB Ginger is a spice and medicinal plant with several varieties. This study aimed to understand the antioxidant, antidiabetic, and antiobesity properties of red ginger (RG) ( Zingiber officinale var. rubrum), through pharmacoinformatics coupled with in vitro studies. Additionally, the suppression of miR-21/132 expression by RG was studied. Two RG extracts were sequentially produced using hexane (RGH) and ethanol (RGE) and characterized using UHPLC-Q-Orbitrap HRMS-based untargeted metabolomics analysis. Seven compounds identified in RGE and six in RGH were subjected to molecular docking tests on iNOS, lipase, alpha-glucosidase, alpha-amylase, and FTO protein receptors. Overall, 5,7-dihydroxy-2-(4-hydroxyphenyl)-6,8-bis(3,4,5-trihydroxyoxan-2-yl)-4H-chromen4-one and pheophorbide A from RGE, and nictoflorin and rutin from RGH showed superior binding to most receptors. In vitro studies confirmed the ability of both RGE and RGH extracts to scavenge DPPH and ABTS radicals; inhibit activities of three metabolic enzymes, lipase (EC50 85.58 and 105.50 mu g/mL), alpha-glucosidase (EC50 of 92.56 and 106.20 mu g/mL), and alpha-amylase (EC50 of 96.60 and 111.80 mu g/mL). Ex vivo RGE and RGH considerably suppressed protein expression associated with obesity, diabetes, and oxidative stress, including miR-21/132. This presents new insights into the molecular mechanism of RG in combating metabolic syndrome; however, further in vivo and clinical trials are needed to validate these findings.
C1 [Rampengan, Derren David Christian Homenta] Univ Sam Ratulangi, Fac Med, Med Study Programme, Manado, Indonesia.
   [Syahputra, Rony Abdi; Halim, Princella; Ramadhan, Roy Novri] Univ Sumatera Utara, Dept Pharmacol, Fac Pharm, Medan, Sumatera Utara, Indonesia.
   [Kumalawati, Dian Aruni; Surya, Reggie] State Islamic Univ Sunan Kalijaga UIN Sunan Kalija, Fac Sci & Technol, Dept Biomed Sci, Yogyakarta 55281, Indonesia.
   [Ramadhan, Roy Novri; Wiyarta, Elvan] Airlangga Univ, Fac Med, Med Study Programme, Surabaya, Indonesia.
   [Surya, Reggie; Permatasari, Happy Kurnia] Bina Nusantara Univ, Fac Engn, Dept Food Technol, Jakarta 11480, Indonesia.
   [Wiyarta, Elvan] Univ Indonesia, Dr Cipto Mangunkusumo Natl 13 Hosp, Fac Med, Dept Neurol, Jakarta 10430, Indonesia.
   [Permatasari, Happy Kurnia] Univ Brawijaya, Fac Med, Dept Biochem & Biomol, Malang 65145, Indonesia.
   [Tjandrawinata, Raymond Rubianto] Atma Jaya Catholic Univ Indonesia, Ctr Pharmaceut & Nutraceut Res & Policy, Jakarta 12930, Indonesia.
   [Taslim, Nurpudji Astuti] Hasanuddin Univ, Fac Med, Dept Nutr, Div Clin Nutr, Makassar 90245, Indonesia.
   [Kim, Bonglee] Kyung Hee Univ, Coll Korean Med, Dept Pathol, Seoul 02447, South Korea.
   [Kim, Bonglee] Kyung Hee Univ, Coll Korean Med, Korean Med Based Drug Repositioning Canc Res Ctr, Seoul 02447, South Korea.
   [Tallei, Trina Ekawati] Univ Sam Ratulangi, Fac Math & Nat Sci, Dept Biol, Manado 95115, Indonesia.
   [Tsopmo, Apollinaire] Carleton Univ, Dept Chem, Food Sci & Nutr Program, 1125 Colonel By Dr, Ottawa, ON K1S 5B6, Canada.
   [Nurkolis, Fahrul] Bioinformat Res Ctr, Malang, Indonesia.
C3 Universitas Sam Ratulangi; University of North Sumatra; Airlangga
   University; Universitas Bina Nusantara; University of Indonesia;
   Brawijaya University; University Katolik Indonesia Atma Jaya;
   Universitas Hasanuddin; Kyung Hee University; Kyung Hee University;
   Universitas Sam Ratulangi; Carleton University
RP Syahputra, RA (corresponding author), Univ Sumatera Utara, Dept Pharmacol, Fac Pharm, Medan, Sumatera Utara, Indonesia.
EM derrenrmed@gmail.com; rony@usu.ac.id; princellahalim20@gmail.com;
   dian.kumalawati@uin-suka.ac.id; roy.novri.ramadhan-2020@fk.unair.ac.id;
   reggie.surya@binus.edu; elvan.wiyarta@ui.ac.id; happykp@ub.ac.id;
   raytjan@yahoo.com; pudji_taslim@yahoo.com; bongleekim@khu.ac.kr;
   trina_tallei@unsrat.ac.id; apollinaire_tsopmo@carleton.ca;
   fahrul.nurkolis.mail@gmail.com
RI Permatasari, Happy Kurnia/AAY-3402-2021; Taslim, Nurpduji/AAP-3464-2021;
   Nurkolis, Fahrul/AAY-1874-2021; Kim, Bonglee/AAH-9077-2020; Wiyarta,
   Elvan/AAS-9738-2021; Surya, Reggie/IAN-2376-2023; Tallei,
   Trina/U-1322-2019; Tsopmo, Apollinaire/AAA-3306-2019; Tjandrawinata,
   Raymond/F-1889-2013
OI Abdi Syahputra, S.Farm., M.Farm, Dr. Rony/0000-0003-2016-0151;
   Tjandrawinata, Raymond/0000-0003-0461-9874; Ramadhan, Roy
   Novri/0000-0001-6100-9015
FU Universitas Sumatera Utara
FX This study was funded by Universitas Sumatera Utara 2024
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   Yang XC, 2022, BRIEF BIOINFORM, V23, DOI 10.1093/bib/bbac087
   Zhang SM, 2022, MOLECULES, V27, DOI 10.3390/molecules27030775
NR 40
TC 0
Z9 0
U1 1
U2 1
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2666-1543
J9 J AGR FOOD RES
JI J. Agric. Food Res.
PD DEC
PY 2024
VL 18
AR 101526
DI 10.1016/j.jafr.2024.101526
EA NOV 2024
PG 10
WC Agriculture, Multidisciplinary; Food Science & Technology
WE Emerging Sources Citation Index (ESCI)
SC Agriculture; Food Science & Technology
GA O5G7F
UT WOS:001371414100001
OA gold
DA 2025-06-11
ER

PT J
AU Okatan, EN
   Durak, AT
   Turan, B
AF Okatan, Esma N.
   Durak, Aysegul Toy
   Turan, Belma
TI Electrophysiological basis of metabolic-syndrome-induced cardiac
   dysfunction
SO CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
LA English
DT Article; Proceedings Paper
CT 2nd European-Section Meeting of the
   International-Academy-of-Cardiovascular-Sciences (IACS)
CY OCT 08-10, 2015
CL Belgrade, SERBIA
SP Int Acad Cardiovascular Sci, European Sect
DE SERCA; heart function; calcium sparks; calcium transients; insulin
   resistance; high sucrose diet; diabetes
ID SARCOPLASMIC-RETICULUM FUNCTION; VENTRICULAR DIASTOLIC DYSFUNCTION;
   IMPAIRED SERCA FUNCTION; CONTRACTILE DYSFUNCTION; INSULIN-RESISTANCE;
   CARDIOMYOCYTE DYSFUNCTION; DIABETIC CARDIOMYOPATHY; RYANODINE RECEPTOR;
   OXIDATIVE STRESS; HEART-FAILURE
AB Myocardial contractility is controlled by intracellular Ca2+ cycling with the contribution of sarcoplasmic reticulum (SR). In this study, we aimed to investigate the role of altered SR function in defective regulation of intracellular Ca2+ levels in rats with metabolic syndrome (MetS) induced by a 16-week high-sucrose drinking-water diet. Electric-field stimulated transient intracellular Ca2+ changes in MetS cardiomyocytes exhibited significantly reduced amplitude (similar to 30%) and prolonged time courses (2-fold), as well as depressed SR Ca2+ loading (similar to 55%) with increased basal Ca2+ level. Consistent with these data, altered ryanodine receptor (RyR2) function and SERCA2a activity were found in MetS cardiomyocytes through Ca2+ spark measurements and caffeine application assay in a state in which sodium calcium exchanger was inhibited. Furthermore, tetracaine application assay results and hyperphosphorylated level of RyR2 also support the "leaky RyR2" hypothesis. Moreover, altered phosphorylation levels of phospholamban (PLN) support the depressed SERCA2a-activity thesis and these alterations in the phosphorylation of Ca2+-handling proteins are correlated with altered protein kinase and phosphatase activity in MetS cardiomyocytes. In conclusion, MetS-rat heart exhibits altered Ca2+ signaling largely due to altered SR function via changes in RyR2 and SERCA2a activity. These results point to RyR2 and SERCA2a as potential pharmacological targets for restoring intracellular Ca2+ homeostasis and, thereby, combatting dysfunction in MetS-rat heart.
C1 [Okatan, Esma N.; Durak, Aysegul Toy; Turan, Belma] Ankara Univ, Dept Biophys, Fac Med, TR-06100 Ankara, Turkey.
C3 Ankara University
RP Turan, B (corresponding author), Ankara Univ, Dept Biophys, Fac Med, TR-06100 Ankara, Turkey.
EM belma.turan@medicine.ankara.edu.tr
RI TURAN, Belma/AAG-8084-2020; durak, aysegul/AAA-7647-2022; Okatan,
   Esma/A-7202-2016; Okatan, Esma Nur/LNP-9142-2024
OI Okatan, Esma Nur/0000-0002-0795-6078; TURAN, Belma/0000-0003-2583-9294
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NR 47
TC 25
Z9 26
U1 0
U2 8
PU CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS
PI OTTAWA
PA 65 AURIGA DR, SUITE 203, OTTAWA, ON K2E 7W6, CANADA
SN 0008-4212
EI 1205-7541
J9 CAN J PHYSIOL PHARM
JI Can. J. Physiol. Pharmacol.
PD OCT
PY 2016
VL 94
IS 10
BP 1064
EP 1073
DI 10.1139/cjpp-2015-0531
PG 10
WC Pharmacology & Pharmacy; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Pharmacology & Pharmacy; Physiology
GA DY9HQ
UT WOS:000385444900006
PM 27322594
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Catanzaro, R
   Calabrese, F
   Occhipinti, S
   Anzalone, MG
   Italia, A
   Milazzo, M
   Marotta, F
AF Catanzaro, Roberto
   Calabrese, Federica
   Occhipinti, Sergio
   Anzalone, Maria Grazia
   Italia, Angelo
   Milazzo, Michele
   Marotta, Francesco
TI Nonalcoholic Fatty Liver Disease Increases Risk for Gastroesophageal
   Reflux Symptoms
SO DIGESTIVE DISEASES AND SCIENCES
LA English
DT Article
DE Nonalcoholic fatty liver; Gastroesophageal reflux disease; Obesity;
   Metabolic syndrome
ID ESOPHAGEAL ACID EXPOSURE; INTERLEUKIN-8 EXPRESSION; OXIDATIVE STRESS;
   REACTIVE OXYGEN; HIGH PREVALENCE; ADIPOSE-TISSUE; OBESITY; MUCOSA;
   PATHOGENESIS; CHEMOKINES
AB Nonalcoholic fatty liver disease (NAFLD) is now recognized as a leading cause of liver dysfunction. Gastroesophageal reflux disease (GERD) is a common disorder causing symptoms that often impair patients' quality of life. In recent years, the prevalence of both these diseases has increased, partially overlapping the rise of metabolic disorders.
   We investigated whether a relation does exist between NAFLD and GERD symptoms.
   Cross-sectional study among 206 outpatients diagnosed with NAFLD and 183 controls. We collected clinical and laboratory data, assessed severity and frequency of GERD symptoms and the esophageal endoscopic pattern.
   The prevalence of GERD symptoms was higher in NAFLD patients than controls (61.2 vs. 27.9 %, p < 0.001). We found a positive association between NAFLD and the experiencing of heartburn, regurgitation and belching. GERD symptoms were related to body mass index (BMI) and metabolic syndrome (MetS); a strong association persisted after adjustment for all the covariates (adjusted OR 3.49, 95 CI % 2.24-5.44, p < 0.001).
   Our data show that the prevalence of GERD typical symptoms is higher in patients with NAFLD. GERD was associated with higher BMI and MetS, but not with age and diabetes type 2. NAFLD remained strongly associated with GERD, independently of a coexisting MetS status. Consistent with these findings, MetS can be considered a shared background, but cannot completely explain this correlation. We suggest NAFLD as an independent risk factor for GERD symptoms.
C1 [Catanzaro, Roberto; Calabrese, Federica; Occhipinti, Sergio; Anzalone, Maria Grazia; Italia, Angelo; Milazzo, Michele] Univ Catania, G Rodolico Hosp, Inst Internal Med A Francaviglia, Sect Gastroenterol,Dept Med & Pediat Sci, I-95123 Catania, Italy.
   [Marotta, Francesco] ReGenera Res Grp Aging Intervent, I-20154 Milan, Italy.
C3 University of Catania
RP Catanzaro, R (corresponding author), Univ Catania, G Rodolico Hosp, Inst Internal Med A Francaviglia, Sect Gastroenterol,Dept Med & Pediat Sci, Bldg 4-1 Floor,Room 17,Via S Sofia 78, I-95123 Catania, Italy.
EM rcatanza@unict.it; fedi.calabrese@gmail.com;
   sergio.occhipinti@gmail.com; mganzalone@gmail.com;
   italiaangelo@tiscali.it; milazzomichele@live.it; fmarchimede@libero.it
RI Marotta, Francesco/ABI-1960-2020; CATANZARO, Roberto/ABE-8085-2020
OI CATANZARO, Roberto/0000-0003-4852-9125; Marotta,
   Francesco/0000-0002-6016-1864; occhipinti, sergio/0000-0002-1059-4901;
   Milazzo, Michele/0000-0002-1882-7095; Calabrese,
   Federica/0000-0001-9097-5562
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NR 60
TC 16
Z9 17
U1 0
U2 6
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0163-2116
EI 1573-2568
J9 DIGEST DIS SCI
JI Dig. Dis. Sci.
PD AUG
PY 2014
VL 59
IS 8
BP 1939
EP 1945
DI 10.1007/s10620-014-3113-7
PG 7
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA AM7MJ
UT WOS:000340051200104
PM 24718860
DA 2025-06-11
ER

PT J
AU Guo, FS
   Dou, JH
   Wang, JX
   Guo, C
   Wu, RY
   Sun, XL
   Hu, YW
   Wei, J
AF Guo, Fan-Shun
   Dou, Jia-Hao
   Wang, Jun-Xiang
   Guo, Chen
   Wu, Rui-Yun
   Sun, Xue-Lu
   Hu, Yi-Wei
   Wei, Jin
TI Association of the stress hyperglycemia ratio for all-cause and
   cardiovascular mortality in population with
   cardiovascular-kidney-metabolic syndrome stages 0-4: evidence from a
   large cohort study
SO DIABETOLOGY & METABOLIC SYNDROME
LA English
DT Article
DE Cardiovascular-kidney-metabolic syndrome; Stress hyperglycemia ratio;
   All-cause mortality
ID INSULIN-RESISTANCE; SEVERE HYPOGLYCEMIA; DISEASE; MECHANISMS; RISK
AB Background The Cardiovascular-kidney-metabolic (CKM) syndrome is a health disorder caused by interactions between cardiovascular disease, kidney disease, and metabolism-related risk factors. The stress hyperglycemia ratio (SHR) has been shown to correlate with the prognosis of participants with diabetes mellitus, heart failure, and myocardial infarction. However, the predictive value of SHR in the CKM syndrome population is unclear and requires further exploration. Methods This study analyzed 19,345 participants from the National Health and Nutrition Examination Survey (1999-2018). CKM syndrome was staged according to the American Heart Association (AHA) guidelines. SHR was calculated using fasting blood glucose (FBG) and glycated hemoglobin type A1c (HbA1c). Participants were grouped into four quartiles based on SHR. The primary and secondary outcomes were all-cause mortality and cardiovascular mortality, respectively. Kaplan-Meier survival curves and Cox proportional hazard regression models were used to evaluate the association between SHR and outcomes. Then, the potential nonlinear relationship was explored using restricted cubic spline (RCS) analysis. We also performed subgroup analyses to assess the effects of different variables. Results A total of 2,736 all-cause deaths and 699 cardiovascular deaths were recorded during a median follow-up period of 115 months. Kaplan-Meier analysis revealed that participants in quartile 2 had the lowest risk for both all-cause and cardiovascular mortality (Log Rank P < 0.05). Multivariate Cox regression demonstrated the lowest all-cause mortality in the 2nd quartile (HR = 0.84, 95% CI = 0.73-0.97, P = 0.015) and the highest all-cause mortality in the 4th quartile (HR = 1.19, 95% CI = 1.03-1.37, P = 0.018), compared with the 1st quartile group of SHR. The RCS curve demonstrated a U-shape association of SHR with both all-cause and cardiovascular mortality, with the lowest points of 0.89 and 0.91, respectively. Conclusions SHR is strongly correlated with prognosis in the CKM syndrome population, with high or low SHR increasing the risk of death. This index shows great potential for predicting the risk of death in this population.
C1 [Guo, Fan-Shun; Dou, Jia-Hao; Guo, Chen; Wu, Rui-Yun; Sun, Xue-Lu; Hu, Yi-Wei; Wei, Jin] Xi An Jiao Tong Univ, Dept Cardiol, Affiliated Hosp 2, Xian 710004, Shaanxi, Peoples R China.
   [Guo, Fan-Shun; Dou, Jia-Hao; Guo, Chen; Wu, Rui-Yun; Sun, Xue-Lu; Hu, Yi-Wei; Wei, Jin] Xi An Jiao Tong Univ, Clin Res Ctr Endem Dis Shaanxi Prov, Affiliated Hosp 2, Xian 710004, Peoples R China.
   [Wang, Jun-Xiang] Xi An Jiao Tong Univ, Med Dept, Xian 710061, Shaanxi, Peoples R China.
C3 Xi'an Jiaotong University; Xi'an Jiaotong University; Xi'an Jiaotong
   University
RP Wei, J (corresponding author), Xi An Jiao Tong Univ, Dept Cardiol, Affiliated Hosp 2, Xian 710004, Shaanxi, Peoples R China.; Wei, J (corresponding author), Xi An Jiao Tong Univ, Clin Res Ctr Endem Dis Shaanxi Prov, Affiliated Hosp 2, Xian 710004, Peoples R China.
EM weijinxjtu@126.com
RI Guo, Fanshun/MYR-4171-2025
FU Shaanxi Provincial Science and Technology Department [2024JC-YBQN-0791,
   2020ZDLSF02-09]
FX This study was also financially supported by the Shaanxi Provincial
   Science and Technology Department (No.2024JC-YBQN-0791, No.
   2020ZDLSF02-09).
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NR 61
TC 0
Z9 0
U1 2
U2 2
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1758-5996
J9 DIABETOL METAB SYNDR
JI Diabetol. Metab. Syndr.
PD MAR 28
PY 2025
VL 17
IS 1
AR 109
DI 10.1186/s13098-025-01671-2
PG 14
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 0TB7Y
UT WOS:001455359900002
PM 40148902
OA gold
DA 2025-06-11
ER

PT J
AU Dow, CA
   Wertheim, BC
   Patil, BS
   Thomson, CA
AF Dow, Caitlin A.
   Wertheim, Betsy C.
   Patil, Bhimanagouda S.
   Thomson, Cynthia A.
TI Daily Consumption of Grapefruit for 6 Weeks Reduces Urine
   F2-Isoprostanes in Overweight Adults with High Baseline Values but Has
   No Effect on Plasma High-Sensitivity C-Reactive Protein or Soluble
   Vascular Cellular Adhesion Molecule 1
SO JOURNAL OF NUTRITION
LA English
DT Article
ID CORONARY-HEART-DISEASE; INFLAMMATORY MARKERS; DIETARY FLAVONOIDS;
   METABOLIC SYNDROME; OXIDATIVE STRESS; BLOOD-PRESSURE; ORANGE JUICE;
   RISK; NARINGENIN; HESPERETIN
AB Individuals with obesity and metabolic syndrome (MetS) are at increased risk of cardiovascular disease, in part due to heightened inflammatory/oxidative processes. Results from epidemiologic and experimental studies suggest that citrus, and grapefruit in particular, may have a role in promoting vascular health, although clinical trial data are lacking. Here, we evaluated the anti-inflammatory/antioxidant effects of habitual grapefruit consumption in 69 overweight/obese men and women and in a subsample of participants with MetS (n = 29). Participants were randomly assigned to either a grapefruit group in which they consumed a low bioactive diet plus 1.5 grapefruit/d for 6 wk (n = 37, n = 14 with MetS) or to a control condition in which a low bioactive diet devoid of citrus was consumed (n = 32, n = 15 with MetS). Plasma soluble vascular adhesion molecule-1 (sVCAM-1), plasma high-sensitivity C-reactive protein (hsCRP), and urinary F2-isoprostanes were evaluated before and after the intervention phase. F2-isoprostane concentrations were not different in the grapefruit versus control arm after the intervention (12.4 +/- 6.4 vs. 15.9 +/- 9.0 ng/mg creatinine, P = 0.16), whereas plasma hsCRP concentrations tended to be lower in the grapefruit versus control arm postintervention (2.1 +/- 1.5 vs. 2.8 +/- 2.0 mg/L, P = 0.09). In adults with MetS, grapefruit consumption tended to result in lower postintervention F2-isoprostane concentrations compared with the control condition (12.0 +/- 4.5 vs. 18.3 +/- 10.9 ng/mg creatinine, P = 0.06). Furthermore, those with high baseline F2-isoprostane concentrations experienced significant reductions in this biomarker in response to grapefruit consumption (P = 0.021). Change in sVCAM-1 concentrations did not vary by treatment arm nor were there differences between arms postintervention. These results suggest that intake of grapefruit twice daily for 6 wk does not significantly reduce inflammation and oxidative stress, although there is a suggestion of favorable modulation of oxidative stress in overweight and obese adults with MetS or those with high baseline urine F2-isoprostane concentrations.
C1 [Dow, Caitlin A.] Univ Arizona, Dept Nutr Sci, Tucson, AZ 85721 USA.
   [Wertheim, Betsy C.] Univ Arizona, Ctr Canc, Tucson, AZ USA.
   [Thomson, Cynthia A.] Univ Arizona, Mel & Enid Zuckerman Coll Publ Hlth, Tucson, AZ USA.
   [Dow, Caitlin A.; Patil, Bhimanagouda S.; Thomson, Cynthia A.] Texas A&M Univ, Vegetable & Fruit Improvement Ctr, College Stn, TX USA.
C3 University of Arizona; University of Arizona; University of Arizona;
   Texas A&M University System; Texas A&M University College Station
RP Dow, CA (corresponding author), Univ Arizona, Dept Nutr Sci, Tucson, AZ 85721 USA.
EM cdow37@gmail.com
RI Patil, Bhimanagouda/C-7620-2013
OI Patil, Bhimanagouda/0000-0001-7189-0432; Dow,
   Caitlin/0000-0002-3217-4078
FU USDA National Needs Fellowship [2010-38420-20369]; USDA Cooperative
   State, Research, Education and Extension Service (USDA-CSREES)
   [2010-34402-20875]
FX This project was funded by USDA National Needs Fellowship
   2010-38420-20369 and the USDA Cooperative State, Research, Education and
   Extension Service (USDA-CSREES) grant 2010-34402-20875.
CR Bailey David G, 2004, Am J Cardiovasc Drugs, V4, P281, DOI 10.2165/00129784-200404050-00002
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NR 27
TC 12
Z9 13
U1 1
U2 12
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0022-3166
EI 1541-6100
J9 J NUTR
JI J. Nutr.
PD OCT
PY 2013
VL 143
IS 10
BP 1586
EP 1592
DI 10.3945/jn.113.175166
PG 7
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 298NW
UT WOS:000330331700008
PM 23902962
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Everaert, I
   Van der Stede, T
   Stautemas, J
   Hanssens, M
   van Aanhold, C
   Baelde, H
   Vanhaecke, L
   Derave, W
AF Everaert, Inge
   Van der Stede, Thibaux
   Stautemas, Jan
   Hanssens, Maxime
   van Aanhold, Cleo
   Baelde, Hans
   Vanhaecke, Lynn
   Derave, Wim
TI Oral anserine supplementation does not attenuate type-2 diabetes or
   diabetic nephropathy in BTBR ob/ob mice
SO AMINO ACIDS
LA English
DT Article
DE Carnosine; Anserine; Diabetes; Diabetic nephropathy; BTBR ob; ob mice
ID CARNOSINE TREATMENT; INGESTION; INHIBITION; STRESS
AB Carnosine, a naturally occurring dipeptide present in an omnivorous diet, has been shown to ameliorate the development of metabolic syndrome, type-2 diabetes (T2D) and early- and advanced-stage diabetic nephropathy in different rodent models. Anserine, its methylated analogue, is more bio-available in humans upon supplementation without affecting its functionality. In this work, we investigated the effect of oral supplementation with anserine or carnosine on circulating and tissue anserine and carnosine levels and on the development of T2D and diabetic nephropathy in BTBR ob/ob mice. BTBR ob/ob mice were either supplemented with carnosine or anserine in drinking water (4 mM) for 18 weeks and compared with non-supplemented BTBR ob/ob and wild-type (WT) mice. Circulating and kidney, but not muscle, carnosine, and anserine levels were enhanced by supplementation with the respective dipeptides in ob/ob mice compared to non-treated ob/ob mice. The evolution of fasting blood glucose, insulin, fructosamine, triglycerides, and cholesterol was not affected by the supplementation regimens. The albumin/creatine ratio, glomerular hypertrophy, and mesangial matrix expansion were aggravated in ob/ob vs. WT mice, but not alleviated by supplementation. To conclude, long-term supplementation with anserine elevates circulating and kidney anserine levels in diabetic mice. However, anserine supplementation was not able to attenuate the development of T2D or diabetic nephropathy in BTBR ob/ob mice. Further research will have to elucidate whether anserine can attenuate milder forms of T2D or metabolic syndrome.
C1 [Everaert, Inge; Van der Stede, Thibaux; Stautemas, Jan; Hanssens, Maxime; Derave, Wim] Univ Ghent, Dept Movement & Sports Sci, Watersportlaan 2, B-9000 Ghent, Belgium.
   [van Aanhold, Cleo; Baelde, Hans] Leiden Univ, Dept Pathol, Med Ctr, Leiden, Netherlands.
   [Vanhaecke, Lynn] Univ Ghent, Dept Vet Publ Hlth & Food Safety, Lab Chem Anal, Ghent, Belgium.
C3 Ghent University; Leiden University; Leiden University Medical Center
   (LUMC); Leiden University - Excl LUMC; Ghent University
RP Everaert, I (corresponding author), Univ Ghent, Dept Movement & Sports Sci, Watersportlaan 2, B-9000 Ghent, Belgium.
EM inge.everaert@ugent.be
RI Baelde, Hans/B-4092-2015; Derave, Wim/B-2554-2014; Vanhaecke,
   Lynn/N-1061-2017
OI Van der Stede, Thibaux/0000-0003-2038-2504; van Aanhold,
   Cleo/0000-0001-7760-7781; Derave, Wim/0000-0002-2225-5587; baelde,
   Hans/0000-0002-1214-500X; Vanhaecke, Lynn/0000-0003-0400-2188
FU Special Research Fund of Ghent University; Research Foundation-Flanders
   (FWO)
FX This study was financially supported by grants from Special Research
   Fund of Ghent University. IE is a recipient of a post-doctoral
   scholarship by the Research Foundation-Flanders (FWO).
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NR 37
TC 10
Z9 10
U1 2
U2 15
PU SPRINGER WIEN
PI WIEN
PA SACHSENPLATZ 4-6, PO BOX 89, A-1201 WIEN, AUSTRIA
SN 0939-4451
EI 1438-2199
J9 AMINO ACIDS
JI Amino Acids
PD AUG
PY 2021
VL 53
IS 8
BP 1269
EP 1277
DI 10.1007/s00726-021-03033-4
EA JUL 2021
PG 9
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA TS6ZX
UT WOS:000673856500001
PM 34264387
DA 2025-06-11
ER

PT J
AU Torquati, L
   Coombes, JS
   Murray, L
   Hasnain, SZ
   Mallard, AR
   McGuckin, MA
   Fassett, RG
   Croci, I
   Ramos, JS
AF Torquati, Luciana
   Coombes, Jeff S.
   Murray, Lydia
   Hasnain, Sumaira Z.
   Mallard, Alistair R.
   McGuckin, Michael A.
   Fassett, Robert G.
   Croci, Ilaria
   Ramos, Joyce S.
TI Fibre Intake Is Independently Associated with Increased Circulating
   Interleukin-22 in Individuals with Metabolic Syndrome
SO NUTRIENTS
LA English
DT Article
DE dietary fibre; immune response; metabolic endotoxemia
ID BETA-CELL FUNCTION; GUT MICROBIOTA; PROTECTION; GLUCOSE; STRESS
AB The positive effects of dietary fibre on gut barrier function and inflammation have not been completely elucidated. Mice studies show gut barrier disruption and diet-induced insulin resistance can be alleviated by cytokine interleukin-22 (IL-22). However, little is known about IL-22 in humans and its association with gut-beneficial nutrients like fibre. We investigated whether fibre intake was associated with circulating levels of IL-22 in 48 participants with metabolic syndrome (MetS). Bivariate analysis was used to explore associations between circulating IL-22, fibre intake, MetS factors, body composition, and cardiorespiratory fitness (peak oxygen uptake, V. O2peak). Hierarchical multiple regression (HMR) was used to test the independent association of fibre intake with circulating IL-22, adjusting for variables correlated with IL-22. Circulating IL-22 was positively associated with fibre intake (rs = 0.393, p < 0.006). The HMR-adjusted model explained 40% of circulating IL-22 variability, and fibre intake significantly improved the prediction model by 8.4% (p < 0.022). Participants with fibre intake above median intake of 21.5 g/day had a significantly higher circulating IL-22 than the lower intake group (308.3 454.4 vs. 69.0 106.4 pg/mL, p < 0.019). Fibre intake is independently associated with increased circulating IL-22 in individuals with MetS. Findings warrant further investigations to evaluate whether changes in dietary fibre intake alter circulating IL-22, and its effects on health outcomes.
C1 [Torquati, Luciana; Coombes, Jeff S.; Mallard, Alistair R.; Fassett, Robert G.; Croci, Ilaria; Ramos, Joyce S.] Univ Queensland, Sch Human Movement & Nutr Sci, Brisbane, Qld 4072, Australia.
   [Torquati, Luciana] Univ Exeter, Sch Sport & Hlth Sci, Exeter EX4 4PY, Devon, England.
   [Murray, Lydia; Hasnain, Sumaira Z.; McGuckin, Michael A.] Univ Queensland, Translat Res Inst, Immunopathol Grp, Inflammatory Dis Biol & Therapeut Grp, Brisbane, Qld 4072, Australia.
   [Hasnain, Sumaira Z.] Univ Queensland, Australian Infect Dis Res Ctr, Brisbane, Qld 4072, Australia.
   [McGuckin, Michael A.] Univ Melbourne, Fac Med Dent & Hlth Sci, Parkville, Vic 3010, Australia.
   [Croci, Ilaria] Norwegian Univ Sci & Technol, Fac Med, Dept Circulat & Med Imaging, KG Jebsen Ctr Exercise Med, N-7491 Trondheim, Norway.
   [Ramos, Joyce S.] Flinders Univ S Australia, Coll Nursing & Hlth Sci, SHAPE Res Ctr, Exercise Sci & Clin Exercise Physiol, Bedford Pk, SA 5042, Australia.
C3 University of Queensland; University of Exeter; University of
   Queensland; University of Queensland; University of Melbourne; Norwegian
   University of Science & Technology (NTNU); Flinders University South
   Australia
RP Torquati, L (corresponding author), Univ Queensland, Sch Human Movement & Nutr Sci, Brisbane, Qld 4072, Australia.; Torquati, L (corresponding author), Univ Exeter, Sch Sport & Hlth Sci, Exeter EX4 4PY, Devon, England.
EM l.torquati@uq.edu.au; jcoombes@uq.edu.au; lydiasorayamurray@gmail.com;
   sumaira.hasnain@mater.uq.edu.au; a.mallard@uq.edu.au;
   michael.mcguckin@unimelb.edu.au; r.fassett@uq.edu.au;
   ilaria.croci@ntnu.no; joyce.ramos@flinders.edu.au
RI Mallard, Alistair/AAD-1147-2019; Croci, Ilaria/M-4452-2013; Fassett,
   Robert/R-3495-2019; McGuckin, Michael/G-2310-2010; Hasnain,
   Sumaira/N-3412-2014; Mallard, Alistair/H-4570-2014; Coombes,
   Jeff/F-1764-2010
OI Hasnain, Sumaira/0000-0001-8577-8628; Ramos, Joyce/0000-0001-8693-6800;
   McGuckin, Michael/0000-0002-8375-2675; Mallard,
   Alistair/0000-0002-7961-1458; Croci, Ilaria/0000-0002-3661-2290;
   Coombes, Jeff/0000-0002-6990-3596
FU Centre for Research on Exercise, Physical Activity and Health
FX Authors would like to thank participants enrolled in EX-MET study for
   their time and interest in the study, and Prof Wendy Brown and the
   Centre for Research on Exercise, Physical Activity and Health for
   financially supporting LT during this research.
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NR 28
TC 6
Z9 6
U1 0
U2 6
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD APR
PY 2019
VL 11
IS 4
AR 815
DI 10.3390/nu11040815
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA HX9SX
UT WOS:000467749800108
PM 30978932
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Wilkins, T
   Tadkod, A
   Hepburn, I
   Schade, RR
AF Wilkins, Thad
   Tadkod, Altaf
   Hepburn, Iryna
   Schade, Robert R.
TI Nonalcoholic Fatty Liver Disease: Diagnosis and Management
SO AMERICAN FAMILY PHYSICIAN
LA English
DT Article
ID CARDIOVASCULAR-DISEASE; FIBROSIS; PREDICTION; STEATOSIS; FIBROTEST;
   STEATOHEPATITIS; QUANTIFICATION; EPIDEMIOLOGY; MARKERS; RISK
AB Nonalcoholic fatty liver disease is characterized by excessive fat accumulation in the liver (hepatic steatosis). Nonalcoholic steatohepatitis is characterized by steatosis, liver cell injury, and inflammation. The mechanism of nonalcoholic fatty liver disease is unknown but involves the development of insulin resistance, steatosis, inflammatory cytokines, and oxidative stress. Nonalcoholic fatty liver disease is associated with physical inactivity, obesity, and metabolic syndrome. Screening is not recommended in the general population. The diagnosis is usually made after an incidental discovery of unexplained elevation of liver enzyme levels or when steatosis is noted on imaging (e.g., ultrasonography). Patients are often asymptomatic and the physical examination is often unremarkable. No single laboratory test is diagnostic, but tests of liver function, tests for metabolic syndrome, and tests to exclude other causes of abnormal liver enzyme levels are routinely performed. Imaging studies, such as ultrasonography, computed tomography, and magnetic resonance imaging, can assess hepatic fat, measure liver and spleen size, and exclude other diseases. Liver biopsy remains the criterion standard for the diagnosis of nonalcoholic steatohepatitis. Noninvasive tests are available and may reduce the need for liver biopsy. A healthy diet, weight loss, and exercise are first-line therapeutic measures to reduce insulin resistance. There is insufficient evidence to support bariatric surgery, metformin, thiazolidinediones, bile acids, or antioxidant supplements for the treatment of nonalcoholic fatty liver disease. The long-term prognosis is not associated with an increased risk of all-cause mortality, cardiovascular disease, cancer, or liver disease. (Am Fam Physician. 2013;88(1):35-42. Copyright (C) 2013 American Academy of Family Physicians.)
C1 [Wilkins, Thad] Georgia Regents Univ, Dept Family Med, Augusta, GA 30912 USA.
   [Tadkod, Altaf] Barrow Reg Med Ctr, Winder, GA USA.
   [Hepburn, Iryna] Good Samaritan Digest Hlth Specialists, Lebanon, PA USA.
   [Schade, Robert R.] Univ Pittsburgh, Presbyterian Med Ctr, Pittsburgh, PA USA.
C3 University System of Georgia; Augusta University; Pennsylvania
   Commonwealth System of Higher Education (PCSHE); University of
   Pittsburgh
RP Wilkins, T (corresponding author), Georgia Regents Univ, 1120 15th St,HB-4032, Augusta, GA 30912 USA.
EM jwilkins@gru.edu
RI Wilkins, Thad/G-2541-2010; Hepburn, Iryna/NFS-6445-2025
OI Wilkins, Thad/0009-0005-8558-7932
CR Angelico F, 2007, COCHRANE DB SYST REV, DOI 10.1002/14651858.CD005166.pub2
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NR 37
TC 58
Z9 64
U1 0
U2 11
PU AMER ACAD FAMILY PHYSICIANS
PI KANSAS CITY
PA 8880 WARD PARKWAY, KANSAS CITY, MO 64114-2797 USA
SN 0002-838X
EI 1532-0650
J9 AM FAM PHYSICIAN
JI Am. Fam. Physician
PD JUL 1
PY 2013
VL 88
IS 1
BP 35
EP 42
PG 8
WC Primary Health Care; Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 178TE
UT WOS:000321469500005
PM 23939604
DA 2025-06-11
ER

PT J
AU Shabrova, E
   Hoyos, B
   Vinogradov, V
   Kim, YK
   Wassef, L
   Leitges, M
   Quadro, L
   Hammerling, U
AF Shabrova, Elena
   Hoyos, Beatrice
   Vinogradov, Valerie
   Kim, Youn-Kyung
   Wassef, Lesley
   Leitges, Michael
   Quadro, Loredana
   Hammerling, Ulrich
TI Retinol as a cofactor for PKCδ-mediated impairment of insulin
   sensitivity in a mouse model of diet-induced obesity
SO FASEB JOURNAL
LA English
DT Article
DE vitamin A; PKC delta signalosome; metabolic syndrome
ID PROTEIN-KINASE-C; ADIPOSE-TISSUE INFLAMMATION; NECROSIS-FACTOR-ALPHA;
   BINDING-PROTEIN; VITAMIN-A; OXIDATIVE STRESS; GENE-EXPRESSION; SERUM
   RETINOL-BINDING-PROTEIN-4; MITOCHONDRIAL DYSFUNCTION; RESISTANCE
AB We previously defined that the mitochondria-localized PKC delta signaling complex stimulates the conversion of pyruvate to acetyl-coenzyme A by the pyruvate dehydrogenase complex. We demonstrated in vitro and ex vivo that retinol supplementation enhances ATP synthesis in the presence of the PKC delta signalosome. Here, we tested in vivo if a persistent oversupply of retinol would further impair glucose metabolism in a mouse model of diet-induced insulin resistance. We crossed mice overexpressing human retinol-binding protein (hRBP) under the muscle creatine kinase (MCK) promoter (MCKhRBP) with the PKC delta(-/-) strain to generate mice with a different status of the PKC delta signalosome and retinoid levels. Mice with a functional PKC delta signalosome and elevated retinoid levels (PKC delta(+/+)hRBP) developed the most advanced stage of insulin resistance. In contrast, elevation of retinoid levels in mice with inactive PKC delta did not affect remarkably their metabolism, resulting in phenotypic similarity between PKC delta(-/-)hRBP and PKC delta(-/-) mice. Therefore, in addition to the well-defined role of PKC delta in the etiology of metabolic syndrome, we present a novel PKC delta signaling pathway that requires retinol as a metabolic cofactor and is involved in the regulation of fuel utilization in mitochondria. The distinct role in whole-body energy homeostasis establishes the PKC delta signalosome as a promising target for therapeutic intervention in metabolic disorders.
C1 [Shabrova, Elena; Hoyos, Beatrice; Vinogradov, Valerie; Hammerling, Ulrich] Mem Sloan Kettering Canc Ctr, Program Immunol, 425 East 68th St, New York, NY 10065 USA.
   [Kim, Youn-Kyung; Wassef, Lesley; Quadro, Loredana; Hammerling, Ulrich] Rutgers State Univ, Dept Food Sci, Rutgers Ctr Lipid Res, POB 231, New Brunswick, NJ 08903 USA.
   [Leitges, Michael] Univ Oslo, Biotechnol Ctr Oslo, Oslo, Norway.
C3 Memorial Sloan Kettering Cancer Center; Rutgers University System;
   Rutgers University New Brunswick; University of Oslo
RP Hammerling, U (corresponding author), Mem Sloan Kettering Canc Ctr, Program Immunol, 425 East 68th St, New York, NY 10065 USA.
EM uhammerling@gmail.com
RI Leitges, Michael/AAN-1953-2021
OI Leitges, Michael/0000-0003-4203-6995
FU Memorial Sloan-Kettering Cancer Center; U.S. National Institutes of
   Health/Eunice Kennedy Shriver National Institute of Child Health and
   Human Development [R01HD057493, R01HD057493-02S1]
FX The authors acknowledge intellectual and material support by the members
   of the Weill-Cornell Pharmacology Department (New York, NY, USA), Drs.
   Lorraine Gudas, Jochen Buck, and Lonny Levine. The authors also thank
   Drs. Giovanni Manfredi and Anatoly Starkov (Cornell Medical College, New
   York, NY, USA) for manyfold advice and Dr. Malcolm Watford (Rutgers
   University, Piscataway, NY, USA) for critical reading of the manuscript.
   The authors are indebted to Dr. J. Friedman (Rockefeller University, New
   York, NY, USA) for help in PIXImus measurements. U.H. was supported by a
   grant from Memorial Sloan-Kettering Cancer Center, and L.Q. by grants
   from the U.S. National Institutes of Health/Eunice Kennedy Shriver
   National Institute of Child Health and Human Development (R01HD057493
   and R01HD057493-02S1). E.S., L.Q., B.H., and U.H. were responsible for
   planning, oversight, and execution of the experiments, as well as of
   interpretation and validation of results. V.V., Y.-K.K., and L.W.
   carried out mouse breeding, maintenance and genotyping experiments, and
   assisted with various analytic procedures. M.L. provided breeding pairs
   of protein kinase C delta knockout mice. The authors declare no
   conflicts of interest.
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NR 108
TC 9
Z9 10
U1 1
U2 8
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
EI 1530-6860
J9 FASEB J
JI Faseb J.
PD MAR
PY 2016
VL 30
IS 3
BP 1339
EP 1355
DI 10.1096/fj.15-281543
PG 17
WC Biochemistry & Molecular Biology; Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA DE1LF
UT WOS:000370387800029
PM 26671999
OA Green Published
DA 2025-06-11
ER

PT J
AU Jumean, MF
   Konstam, MA
AF Jumean, Marwan F.
   Konstam, Marvin A.
TI Heart Failure With Preserved Ejection Fraction What Is in a Name?
SO CARDIOLOGY IN REVIEW
LA English
DT Review
DE heart failure with preserved ejection fraction; HFpEF; heart failure;
   metabolic heart failure; senile heart failure; metabolic syndrome;
   diastolic function; elderly
ID VENTRICULAR SYSTOLIC FUNCTION; DIASTOLIC DYSFUNCTION; CARDIAC FIBROSIS;
   MYOCARDIAL-INFARCTION; ANGIOTENSIN-II; CARDIOVASCULAR EVENTS;
   HYPERTENSIVE PATIENTS; CARDIORENAL SYNDROME; NATRIURETIC-PEPTIDE;
   PASSIVE STIFFNESS
AB Evidence-based management of heart failure (HF) with preserved left ventricular ejection fraction (LVEF; HFpEF) remains a major gap in the care of patients with HF. Clinical trials directed toward the population with HFpEF have been disappointing, although renin-angiotensin-aldosterone system blockade appears to prevent HF in populations predisposed to HFpEF. This paradox may partly be because of inhomogeneity within the HF populations studied. Although the term HFpEF is often used to imply a specific diagnosis, in fact this constellation may be due to a large variety of disease states with different underlying pathophysiologic mechanisms. Furthermore, in patients with HF, regardless of LVEF, myocardial dysfunction is common during both systole and diastole, and LVEF is influenced at least as much by the pattern of left ventricular remodeling as it is by myocardial contractility. The most common clinical-pathologic syndrome responsible for HFpEF is strongly associated with hypertension, with the metabolic syndrome, and with older age. Recent findings support that this condition is mediated via endothelial dysfunction, inflammation, oxidative stress, myocyte hypertrophy, and altered collagen turnover. We, therefore, propose the terms metabolic HF and senile HF to describe this specific disease state. The search for therapies designed to prevent, halt, or reverse HF should more strongly focus on populations carefully selected to represent specific underlying cardiovascular disease states.
C1 [Jumean, Marwan F.; Konstam, Marvin A.] Tufts Univ, Tufts Med Ctr, Sch Med, CardioVasc Ctr, Boston, MA 02111 USA.
C3 Tufts University; Tufts Medical Center
RP Konstam, MA (corresponding author), Tufts Univ, Tufts Med Ctr, Sch Med, 800 Washington St,Box 108, Boston, MA 02111 USA.
EM mkonstam@tuftsmedicalcenter.org
RI Jumean, Marwan/ABC-7306-2020
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NR 91
TC 7
Z9 7
U1 0
U2 12
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1061-5377
EI 1538-4683
J9 CARDIOL REV
JI Cardiol. Rev.
PD JUL-AUG
PY 2015
VL 23
IS 4
BP 161
EP 167
DI 10.1097/CRD.0000000000000057
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA CM2CK
UT WOS:000357487200002
PM 25688660
DA 2025-06-11
ER

PT J
AU Panahi, Y
   Hosseini, MS
   Khalili, N
   Naimi, E
   Majeed, M
   Sahebkar, A
AF Panahi, Yunes
   Hosseini, Mahboobeh Sadat
   Khalili, Nahid
   Naimi, Effat
   Majeed, Muhammed
   Sahebkar, Amirhossein
TI Antioxidant and anti-inflammatory effects of curcuminoid-piperine
   combination in subjects with metabolic syndrome: A randomized controlled
   trial and an updated meta-analysis
SO CLINICAL NUTRITION
LA English
DT Review
DE Curcuma longa; Turmeric; Cardiovascular disease; Antioxidant; Randomized
   controlled trial
ID C-REACTIVE PROTEIN; DOUBLE-BLIND; MYOCARDIAL-INFARCTION; ENDOTHELIAL
   FUNCTION; CLINICAL-PRACTICE; OXIDATIVE STRESS; IN-VITRO; INFLAMMATION;
   ASSOCIATION; RISK
AB Background: Oxidative stress and inflammation have been proposed as emerging components of metabolic syndrome (MetS). Curcuminoids are natural polyphenols with strong antioxidant and anti-inflammatory properties. Objective: To study the effectiveness of supplementation with a bioavailable curcuminoid preparation on measures of oxidative stress and inflammation in patients with MetS. Our secondary aim was to perform a meta-analysis of data from all randomized controlled trials in order to estimate the effect size of curcuminoids on plasma C-reactive protein (CRP) concentrations.
   Methods: In this randomized double-blind placebo-controlled trial, 117 subjects with MetS (according to the NCEP-ATPIII diagnostic criteria) were randomly assigned to curcuminoids (n = 59; drop-outs = 9) or placebo (n = 58; drop-outs = 8) for eight weeks. Curcuminoids were administered at a daily dose of 1 g, and were co-supplemented with piperine (10 mg/day) in order to boost oral bioavailability. Serum activities of superoxide dismutase (SOD) and concentrations of malondialdehyde (MDA) and CRP were measured at baseline and at study end. Regarding the importance of CRP as a risk marker and risk factor of cardiovascular disease, a random-effects meta-analysis of clinical trials was performed to estimate the overall impact of curcuminoid therapy on circulating concentrations of CRP. The robustness of estimated effect size was evaluated using leave-one-out sensitivity analysis.
   Results: Supplementation with curcuminoid-piperine combination significantly improved serum SOD activities (p < 0.001) and reduced MDA (p < 0.001) and CRP (p < 0.001) concentrations compared with placebo. Quantitative data synthesis revealed a significant effect of curcuminoids vs. placebo in reducing circulating CRP concentrations (weighed mean difference: -2.20 mg/L; 95% confidence interval [CI]: -3.96, -0.44; p = 0.01). This effect was robust in sensitivity analysis.
   Conclusions: Short-term supplementation with curcuminoid-piperine combination significantly improves oxidative and inflammatory status in patients with MetS. Curcuminoids could be regarded as natural, safe and effective CRP-lowering agents. (C) 2015 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.
C1 [Panahi, Yunes] Baqiyatallah Univ Med Sci, Chem Injuries Res Ctr, Tehran, Iran.
   [Hosseini, Mahboobeh Sadat; Khalili, Nahid; Naimi, Effat] Baqiyatallah Univ Med Sci, Dept Endocrinol, Tehran, Iran.
   [Majeed, Muhammed] Sabinsa Inc, Princeton, NJ USA.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Biotechnol Res Ctr, Mashhad, Iran.
   [Sahebkar, Amirhossein] Univ Western Australia, Metab Res Ctr, Royal Perth Hosp, Sch Med & Pharmacol, Perth, WA 6009, Australia.
C3 Baqiyatallah University of Medical Sciences (BMSU); Baqiyatallah
   University of Medical Sciences (BMSU); Mashhad University of Medical
   Sciences; East Metropolitan Health Service; Royal Perth Hospital;
   University of Western Australia
RP Sahebkar, A (corresponding author), Mashhad Univ Med Sci, Sch Med, Dept Med Biotechnol, POB 91779-48564, Mashhad, Iran.
EM sahebkara@mums.ac.ir
RI Sahebkar, Amirhossein/B-5124-2018; Hosseini, Mahboobeh/U-9514-2018;
   naeimi, effat/U-3221-2019; Khalili, Nahid/U-1226-2019
OI hosseini, mahboobeh sadat/0000-0001-8863-1269; naeimi,
   effat/0000-0001-9513-3700; Panahi, Yunes/0000-0002-2504-8356
FU Clinical Trial Research Center (Tehran, Iran); Iran National Science
   Foundation (INSF)
FX This study was financially supported by Clinical Trial Research Center
   (Tehran, Iran) and Iran National Science Foundation (INSF).
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NR 72
TC 310
Z9 323
U1 9
U2 83
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0261-5614
EI 1532-1983
J9 CLIN NUTR
JI Clin. Nutr.
PD DEC
PY 2015
VL 34
IS 6
BP 1101
EP 1108
DI 10.1016/j.clnu.2014.12.019
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA CZ0IV
UT WOS:000366789300008
PM 25618800
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Krishnan, E
AF Krishnan, Eswar
TI Hyperuricemia and Incident Heart Failure
SO CIRCULATION-HEART FAILURE
LA English
DT Article
DE heart failure; risk; uric acid; incidence; hyperuricemia; prospective
   studies; biological markers
ID SERUM URIC-ACID; XANTHINE-OXIDASE INHIBITION; ACUTE
   MYOCARDIAL-INFARCTION; C-REACTIVE PROTEIN; METABOLIC SYNDROME;
   LONG-TERM; BLOOD-PRESSURE; CARDIOVASCULAR MORTALITY;
   ESSENTIAL-HYPERTENSION; GOUT
AB Background-Hyperuricemia, a known correlate of oxidative stress, is a marker for adverse prognosis among individuals with heart failure. However, the relationship between hyperuricemia and the risk for incidence of heart failure in a community-based population has not been studied.
   Methods and Results-We prospectively analyzed the relationship between serum uric acid concentration at baseline and subsequent heart failure among the participants of the Framingham Offspring cohort (n = 4912; mean baseline age, 36 years; 52% women). By using Cox regressions, we calculated the risk of heart failure with increasing serum uric acid after adjusting for sex, age, smoking, body mass index, renal dysfunction, diuretics, systolic blood pressure, valvular heart disease, diabetes, alcohol, and use of antihypertensive medications. The incidence rates of heart failure were approximate to 6-fold higher among those at the highest quartile of serum uric acid (>6.3 mg/dL) compared with those at the lowest quartile (<3.4 mg/dL). The adjusted hazard ratio for the highest quartile of serum uric acid compared with the lowest was 2.1 (1.04 to 4.22). The relationship between hyperuricemia and heart failure was found in participants without metabolic syndrome and other subgroups as well.
   Conclusions-Hyperuricemia is a novel, independent risk factor for heart failure in a group of young general community dwellers. This has implications for development of preventive strategies for heart failure. (Circ Heart Fail. 2009; 2: 556-562.)
C1 [Krishnan, Eswar] Stanford Univ, Dept Med, Sch Med, Stanford, CA 94305 USA.
C3 Stanford University
RP Krishnan, E (corresponding author), 1000 Welch Rd,Suite 203, Stanford, CA 94304 USA.
EM e.krishnan@stanford.edu
RI krishnan, Eswar/AAY-1269-2020
FU National Center for Research Resources [KL2 RR024154-01]; National
   Institutes of Health; National Institutes of Health Roadmap
FX The Framingham Offspring Study is conducted and supported by the
   National Heart, Lung, and Blood Institute in collaboration with the
   Framingham Offspring Study Investigators. This research was supported in
   part by grant KL2 RR024154-01 from the National Center for Research
   Resources, a component of the National Institutes of Health, and
   National Institutes of Health Roadmap for Medical Research. Its contents
   are solely the responsibility of the authors and do not necessarily
   represent the official view of the National Center for Research
   Resources, the National Heart, Lung, and Blood Institute, or the
   National Institutes of Health. Information on the National Center for
   Research Resources is available at http://www.ncrr.nih.gov. Information
   on Reengineering the Clinical Research Enterprise is available at
   http://nihroadmap.nih.gov/clinicalresearch/ overview-translational. asp.
   No commercial products are discussed in this manuscript.
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NR 48
TC 98
Z9 108
U1 1
U2 8
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1941-3289
J9 CIRC-HEART FAIL
JI Circ.-Heart Fail.
PD NOV
PY 2009
VL 2
IS 6
BP 556
EP 562
DI 10.1161/CIRCHEARTFAILURE.108.797662
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 521BD
UT WOS:000271893100006
PM 19919980
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Jakubczyk, A
AF Jakubczyk, Anna
TI Effect of addition of fermented bean seed flour on the content of
   bioactive components and nutraceutical potential of wheat wafers
SO LWT-FOOD SCIENCE AND TECHNOLOGY
LA English
DT Article
DE Fermented bean seed flour; Wafers; Bioactive compounds; Antioxidant
   activity; Metabolic syndrome
ID GLUTEN-FREE BREAD; METABOLIC SYNDROME; ANTIDIABETIC PROPERTIES;
   ANTIOXIDANT ACTIVITY; INHIBITORY PEPTIDES; OXIDATIVE STRESS;
   HEAT-TREATMENT; PROTEIN; QUALITY; DIGESTION
AB In this study the influence of fermented bean seed flour (BF) with Lactobacillus plantarum 299v on bioactive compounds, antioxidant activity and selected inhibitory activity of wheat wafers were investigated. Wheat wafers with addition of BF (10%, 20%, 30%, 40% and 50%), fermented bean flour wafers (100%) and wheat wafers (WF) were prepared. The results indicated that wafers made from 100% fermented bean seed flour were characterized by the highest content of bioactive compounds (0.086 mg mL(-1) for proteins, 0.79 mg mL(-1) for peptides, and 0.46 mg mL(-1) for polyphenols), compared with the control sample. The highest peptide content after the hydrolysis process and DH were found for 100% BF (2.29 mg mL(-1) and 32.81%, respectively). The antiradical activity against ABTS(center dot+) was noted for hydrolysates obtained from 40% BF (IC50 = 17.81 mu g mL-(1)) and against DPPH in the case of hydrolysates from 30% BF (IC50 = 34.43 mu g mL-(1)). In turn, 50% BF exhibited higher Fe2+ chelating activity than the control sample (IC50 = 4.57 mu g mL-(1)). The IC50 values were the same for hydrolysates from wafers with 50% BF and 100% BF and 0.14, 0.24, and 0.19 mg mL(-1) for alpha-glucosidase, lipase, and ACE respectively.
C1 [Jakubczyk, Anna] Univ Life Sci, Dept Biochem & Food Chem, Skromna 8, PL-20704 Lublin, Poland.
RP Jakubczyk, A (corresponding author), Univ Life Sci, Dept Biochem & Food Chem, Skromna 8, PL-20704 Lublin, Poland.
EM anka_jakubczyk@tlen.pl
OI Jakubczyk, Anna/0000-0002-1087-2000
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NR 45
TC 13
Z9 14
U1 0
U2 19
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0023-6438
EI 1096-1127
J9 LWT-FOOD SCI TECHNOL
JI LWT-Food Sci. Technol.
PD DEC
PY 2018
VL 98
BP 245
EP 251
DI 10.1016/j.lwt.2018.08.052
PG 7
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA GZ1PY
UT WOS:000449141200033
DA 2025-06-11
ER

PT J
AU Fluitt, MB
   Rizvi, S
   Li, LJ
   Alunan, A
   Lee, H
   Tiwari, S
   Ecelbarger, CM
AF Fluitt, Maurice B.
   Rizvi, Sophia
   Li, Lijun
   Alunan, Ashley
   Lee, Hwal
   Tiwari, Swasti
   Ecelbarger, Carolyn M.
TI Chronic Insulin Infusion Down-Regulates Circulating and Urinary Nitric
   Oxide (NO) Levels Despite Molecular Changes in the Kidney Predicting
   Greater Endothelial NO Synthase Activity in Mice
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE heart rate; blood pressure; oxidative stress; metabolic syndrome;
   hypertension
ID INDUCED HYPERTENSION; COLLECTING DUCT; BLOOD-PRESSURE; METABOLIC
   SYNDROME; RATS; HYPERINSULINEMIA; DYSFUNCTION; ENAC; MECHANISMS;
   RESISTANCE
AB Insulin therapy is often needed to overcome insulin receptor resistance in type 2 diabetes; however, the impact of providing additional insulin to already hyperinsulinemic subjects is not clear. We infused male TALLYHO/Jng (TH) mice (insulin resistant) with insulin (50 U/kgbw/d) or vehicle (control) by osmotic minipump for 14 days. One group of insulin-infused mice was switched to 4% NaCl diet (high-sodium diet, HSD) in the second week. Blood chemistry revealed a significantly higher anion gap and blood sodium concentrations with insulin infusion, i.e., relative metabolic acidosis. Systolic BP and heart rate were slightly (5 mm Hg) higher in insulin-infused versus control mice. HSD resulted in a modest and transient rise in mean arterial blood pressure (BP), relative to control or insulin-infused, normal-NaCl-fed mice. In kidney, insulin infusion: (1) increased total and phosphorylated (serine-1177) endothelial nitric oxide synthase (eNOS) band densities; (2) reduced band density of the uncoupled form of eNOS; and (3) increased renal homogenate nitric oxide synthase (NOS) activity. Despite this, plasma and urine levels of nitrates plus nitrites (NOx) fell with insulin infusion, by day 14 (40-50%) suggesting worsening of resistance. Overall, insulin infusion ramps up the cellular means in kidney to increase vasodilatory and natriuretic NO, but in the long term may be associated with worsening of insulin receptor resistance.
C1 [Fluitt, Maurice B.; Rizvi, Sophia; Li, Lijun; Alunan, Ashley; Lee, Hwal; Ecelbarger, Carolyn M.] Georgetown Univ, Dept Med, Div Endocrinol & Metab, Washington, DC 20057 USA.
   [Alunan, Ashley] Willamette Univ, Salem, OR 97301 USA.
   [Tiwari, Swasti] Sanjay Gandhi Postgrad Inst Med Sci, Dept Mol Med & Biotechnol, Lucknow 226014, Uttar Pradesh, India.
C3 Georgetown University; Willamette University; Sanjay Gandhi Postgraduate
   Institute of Medical Sciences
RP Ecelbarger, CM (corresponding author), Georgetown Univ, Dept Med, Div Endocrinol & Metab, Washington, DC 20057 USA.
EM mbf79@georgetown.edu; sophiarizvi@health.usf.edu; lil@georgetown.edu;
   amalunan@willamette.edu; hwal.lee17@gmail.com; tiwari_pgi@yahoo.com;
   ecelbarc@georgetown.edu
OI Fluitt, Maurice/0000-0002-6963-3311; Lee, Hwal/0009-0007-4626-3657
FU GUMCs Faculty Research Support, Department of Medicine, Georgetown
   University; Clinical and Translational Award [NIH TL-1TR001431]; Sanjay
   Gandhi Postgraduate Institute of Medical Sciences
FX This project was supported in part by GUMCs Faculty Research Support,
   Department of Medicine, Georgetown University (CE). Additional funding
   sources include a Clinical and Translational Award (NIH TL-1TR001431
   scholar program, MF). ST was supported by Sanjay Gandhi Postgraduate
   Institute of Medical Sciences.
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NR 35
TC 9
Z9 9
U1 0
U2 1
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD OCT
PY 2018
VL 19
IS 10
AR 2880
DI 10.3390/ijms19102880
PG 13
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA GY9HB
UT WOS:000448951000035
PM 30249002
OA gold, Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Molli, AEI
   Panero, J
   Dos Santos, PC
   González, CD
   Vilariño, J
   Sereday, M
   Cerrone, GE
   Slavutsky, I
   Frechtel, GD
AF Iglesias Molli, Andrea E.
   Panero, Julieta
   Dos Santos, Patricia C.
   Gonzalez, Claudio D.
   Vilarino, Jorge
   Sereday, Marta
   Cerrone, Gloria E.
   Slavutsky, Irma
   Frechtel, Gustavo D.
TI Metabolically healthy obese women have longer telomere length than obese
   women with metabolic syndrome
SO PLOS ONE
LA English
DT Article
ID UNHEALTHY NORMAL-WEIGHT; PERIPHERAL-BLOOD CELLS; CARDIOVASCULAR-DISEASE;
   INSULIN-RESISTANCE; CIGARETTE-SMOKING; RISK; ASSOCIATION; STRESS; DIET;
   AGE
AB Introduction
   Obesity is the principal component in the Metabolic Syndrome (MetS) that determines the progression of metabolic complications. Metabolically healthy obese (MHO) individuals seem to be protected against those complications. Telomere length (TL) as a novel marker of cellular aging had a complex relationship to the MetS. The principal aim of this study was to investigate the TL in MHO, and to study the association between TL and the worsening of the metabolic condition.
   Material and methods
   We have determined the absolute TL (aTL) in 400 women (mean age of 46.76 +/- 15.47 years; range: 18-86 years), grouped according to the metabolic condition in three groups: metabolically healthy non-obese women (MHNO), MHO and obese women with MetS (MSO); and grouped according to the number of components of MetS.
   Results
   We found that MHO displays significantly higher aTL than MSO (p = 0.033; r = -4.63; 95% CI r = -8.89/-0.37), but did not differ from MHNO. A decrease in aTL with the progressive increase in the number of MetS components was also observed (p < 0.001; r = -2.06; 95% CI r = -3.13/-0.99). In this way, our results indicate that aTL is influenced by the presence of MetS, but it is not affected by the presence of obesity.
   Discussion
   We found that shorter aTL is not associated with MHO, but is related to MetS and with the increased number of metabolic abnormalities.
C1 [Iglesias Molli, Andrea E.; Frechtel, Gustavo D.] Univ Buenos Aires, CONICET, Inst Inmunol Genet & Metab INIGEM, Lab Diabet & Metab, Buenos Aires, DF, Argentina.
   [Panero, Julieta; Dos Santos, Patricia C.; Slavutsky, Irma] Acad Nacl Med Buenos Aires, CONICET, Inst Med Expt IMEX, Lab Genet Neoplasias Linfoides, Buenos Aires, DF, Argentina.
   [Gonzalez, Claudio D.] Univ Buenos Aires, Fac Med, Dept Farmacol, Catedra 2, Buenos Aires, DF, Argentina.
   [Vilarino, Jorge] Hosp FLENI, Dept Cardiol, Buenos Aires, DF, Argentina.
   [Sereday, Marta] Hosp Fiorito, Serv Endocrinol, Buenos Aires, DF, Argentina.
   [Cerrone, Gloria E.] Univ Buenos Aires, Fac Farm & Bioquim, Dept Microbiol Inmunol & Biotecnol, Catedra Genet, Buenos Aires, DF, Argentina.
C3 Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET);
   University of Buenos Aires; Buenos Aires National Academy of Medicine;
   IMEX - Instituto de Medicina Experimental; Consejo Nacional de
   Investigaciones Cientificas y Tecnicas (CONICET); University of Buenos
   Aires; University of Buenos Aires
RP Molli, AEI (corresponding author), Univ Buenos Aires, CONICET, Inst Inmunol Genet & Metab INIGEM, Lab Diabet & Metab, Buenos Aires, DF, Argentina.
EM andrea.iglesiasmolli@gmail.com
OI Gonzalez, Claudio/0000-0002-3772-8850
FU Sanofi Aventis Laboratory
FX This work was financially supported by an unrestricted grant of Sanofi
   Aventis Laboratory to Gustavo D. Frechtel. The funder had no role in
   study design, data collection and analysis, decision to publish, or
   preparation of the manuscript.
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NR 44
TC 17
Z9 17
U1 0
U2 3
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD APR 6
PY 2017
VL 12
IS 4
AR e0174945
DI 10.1371/journal.pone.0174945
PG 13
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA ES2QB
UT WOS:000399371900060
PM 28384193
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Verma, S
   Moiz, JA
   Anwer, S
   Alghadir, AH
   Hussain, ME
AF Verma, Shalini
   Moiz, Jamal Ali
   Anwer, Shahnawaz
   Alghadir, Ahmad H.
   Hussain, Mohammed Ejaz
TI A dose-response study of aerobic training for oxygen uptake, oxidative
   stress and cardiac autonomic function in type 2 diabetes mellitus: study
   protocol for a randomized controlled trial
SO TRIALS
LA English
DT Article
DE Heart rate variability; Metabolic control; Cardiopulmonary fitness;
   Aerobic training; Oxygen uptake; Diabetes
ID ANTIOXIDANT STATUS; GLYCEMIC CONTROL; NITRIC-OXIDE; RISK-FACTORS;
   EXERCISE; COMPLICATIONS; INCREASES; GLYCATION; BENEFITS; DISEASE
AB Background: Cardiac autonomic neuropathy is a commonly overlooked complication of type 2 diabetes mellitus (T2DM) characterized by an imbalance between sympathetic and parasympathetic supply to the heart, which contributes to cardiovascular morbidity and mortality. T2DM has also been shown to negatively influence oxygen kinetics and increase oxidative stress, which may be linked to the development of various chronic complications. Aerobic training has been reported to improve oxygen uptake, antioxidant defense, and cardiac autonomic function in T2DM; however, the effects of varying doses of exercise on these variables are not known. Therefore, the aim of the present study is to explore the effects of manipulating training variables (volume and intensity) on the regulation of oxygen uptake response, oxidative stress, and cardiac autonomic function in patients with T2DM.
   Methods: We will recruit 60 patients with T2DM, who will be randomly allocated into one of the three aerobic training groups: low-intensity, low-volume training; low-intensity, high volume-training; high-intensity, high-volume training; or to the control group receiving no supervised exercise. All participants will be assessed for the rate of oxygen uptake, levels of antioxidant enzymes and cardiac autonomic function at baseline and after 12 weeks of training. Secondary outcome measures will include cardiometabolic risk factors and body composition.
   Discussion: Despite a large body of evidence on the efficacy of aerobic training in the prevention and treatment of T2DM, there is no unequivocal exercise prescription for the same. Oxygen kinetics and oxidative stress are highly sensitive to the magnitude of physical activity. It would therefore, be interesting to study their interaction with chronic exposure to various doses of exercises and explore the optimal volume and intensity to bring about improvements in these parameters.
C1 [Verma, Shalini; Moiz, Jamal Ali; Hussain, Mohammed Ejaz] Jamia Millia Islamia, Ctr Physiotherapy & Rehabil Sci, New Delhi 110025, India.
   [Anwer, Shahnawaz; Alghadir, Ahmad H.] King Saud Univ, Coll Appl Med Sci, Dept Rehabil, Riyadh, Saudi Arabia.
C3 Jamia Millia Islamia; King Saud University
RP Hussain, ME (corresponding author), Jamia Millia Islamia, Ctr Physiotherapy & Rehabil Sci, New Delhi 110025, India.
EM ehusainjmi@gmail.com
RI Moiz, Jamal/G-3369-2018; ANWER, SHAHNAWAZ/AAW-1994-2020; Alghadir, Ahmad
   H./HKO-9206-2023
OI ANWER, SHAHNAWAZ/0000-0003-3187-8062; Alghadir, Ahmad
   H./0000-0002-1204-476X
FU Scientific Research at King Saud University [RGP-VPP-209]
FX This project is being funded by the Deanship of Scientific Research at
   King Saud University through the research group number RGP-VPP-209. The
   funding body played no role in study design, the writing of the
   manuscript or the decision to submit the manuscript for publication.
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NR 41
TC 6
Z9 8
U1 0
U2 17
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1745-6215
J9 TRIALS
JI Trials
PD MAY 24
PY 2018
VL 19
AR 289
DI 10.1186/s13063-018-2671-y
PG 10
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA GH5JF
UT WOS:000433456300002
PM 29793518
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Fan, JG
AF Fan, Jian Gao
TI Impact of non-alcoholic fatty liver disease on accelerated metabolic
   complications
SO JOURNAL OF DIGESTIVE DISEASES
LA English
DT Review
DE alanine aminotransferase; gamma-glutamyltransferase; insulin resistance;
   metabolic syndrome; non-alcoholic fatty liver disease; type 2 diabetes
   mellitus
ID ASIA-PACIFIC REGION; ALANINE AMINOTRANSFERASE; INSULIN-RESISTANCE;
   RISK-FACTORS; CARDIOVASCULAR-DISEASE; POPULATION; PREVALENCE;
   STEATOHEPATITIS; DEFINITIONS; ELEVATIONS
AB Insulin resistance is the basis of both non-alcoholic fatty liver disease (NAFLD) and metabolic syndrome (MetS), the two conditions are often found in the same individual. The mortality of patients with NAFLD is significantly higher than that among the general population and cardiovascular risk may compete with liver-related risk in dictating the final outcome. Recent prospective studies have reported that NAFLD is associated with an increased incidence of MetS and type 2 diabetes mellitus, independent of obesity and other components of MetS. Thus, NAFLD may not only be a liver disease but also an early mediator of type 2 diabetes mellitus and MetS. The biological mechanisms by which NAFLD contributes to a higher risk of developing metabolic disorders are not fully understood. However, the fatty liver could contribute in the same way as visceral adipose tissue to insulin resistance, systemic inflammation and oxidative stress, while the decreased serum adiponectin concentrations might also be part of the mechanism. In contemporary clinical practice, it has become mandatory to evaluate the metabolic risk factors in NAFLD patients and to consider careful surveillance and aggressive treatment, not only of the resultant liver disease, but also of the possible underlying metabolic and vascular complications. Future studies might address the question whether earlier adjustment to a more efficient lifestyle or a pharmacological treatment that mobilizes fat out of the liver could reduce these risks.
C1 Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 1, Dept Gastroenterol, Ctr Fatty Liver Dis, Shanghai 200080, Peoples R China.
C3 Shanghai Jiao Tong University
RP Fan, JG (corresponding author), Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 1, Dept Gastroenterol, Ctr Fatty Liver Dis, Shanghai 200080, Peoples R China.
EM fanjiangao@gmail.com
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NR 40
TC 31
Z9 54
U1 0
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1751-2972
EI 1751-2980
J9 J DIGEST DIS
JI J. Dig. Dis.
PD MAY
PY 2008
VL 9
IS 2
BP 63
EP 67
DI 10.1111/j.1751-2980.2008.00323.x
PG 5
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 316XN
UT WOS:000256983200001
PM 18419637
OA Bronze
DA 2025-06-11
ER

PT J
AU Severcan, SM
   Koca, G
   Severcan, Ç
   Yilmaz, C
   Pasaoglu, Ö
   Pasaoglu, H
AF Severcan, Suzan Muratoglu
   Koca, Gulce
   Severcan, Cinar
   Yilmaz, Canan
   Pasaoglu, OzgeTugce
   Pasaoglu, Hatice
TI Effect of curcumin on plasma TBARS and IL-6, adipose tissue AFABP-4 and
   liver FGF-21 in fructose-induced metabolic syndrome rats
SO INDIAN JOURNAL OF EXPERIMENTAL BIOLOGY
LA English
DT Article
DE Curcuma longa; Fructose administration; Inflammation; Oxidative stress;
   Turmeric
ID INFLAMMATION
AB Elucidation of the positive effects of curcumin on oxidative damage and inflammation, as well as clarifying the parameters related to adipose tissue and liver, would contribute furthermore to literature. Here, we have demonstrated the potential healing effects of curcumin in rats with metabolic syndrome (MetS). Twenty-four adult male Wistar albino rats were selected for the study. Only corn oil was administered to the control group rats, while corn oil and 20% fructose were administered to the MetS group rats for eight weeks. The curcumin dose groups were administered 100 and 200 mg/kg of curcumin dissolved in corn oil along with 20% fructose. Plasma TBARS, IL-6, adipose AFABP-4 and liver FGF-21 levels were determined using the ELISA method. It was observed that plasma TBARS and IL-6 levels were significantly decreased in the 100 and 200 mg/kg curcumin dose groups compared to the MetS group (P <0.008). Adipose tissue A-FABP-4 levels in the 200 mg/kg curcumin dose group were significantly decreased compared to the MetS group (P <0.008). FGF-21 levels in the 100 mg/kg and 200 mg/kg curcumin dose groups were significantly increased compared to the MetS group (P <0.008). The healing effects of curcumin administration on MetS were effective on inflammation and lipid peroxidation. Curcumin administration decreased the adipose tissue AFABP-4 levels and increased the liver FGF-21 levels.
C1 [Severcan, Suzan Muratoglu; Pasaoglu, OzgeTugce] Gazi Univ, Inst Hlth Sci, Dept Med Biochem, Ankara, Turkiye.
   [Koca, Gulce; Yilmaz, Canan; Pasaoglu, Hatice] Gazi Univ, Fac Med, Dept Biochem, Ankara, Turkiye.
   [Severcan, Cinar] Zonguldak Bulent Ecevit Univ, Fac Pharm, Dept Biochem, Zonguldak, Turkiye.
C3 Gazi University; Gazi University; Zonguldak Bulent Ecevit University
RP Severcan, SM (corresponding author), Gazi Univ, Inst Hlth Sci, Dept Med Biochem, Ankara, Turkiye.; Severcan, Ç (corresponding author), Zonguldak Bulent Ecevit Univ, Fac Pharm, Dept Biochem, Zonguldak, Turkiye.
RI Yılmaz, Canan/AAT-7788-2020
OI YILMAZ, CANAN/0000-0002-6799-6522
FU Gazi University Scientific Research Projects [01/2019-16]
FX Acknowledgement This work was done under the project numbered 01/2019-16
   funded by Gazi University Scientific Research Projects.
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NR 41
TC 1
Z9 1
U1 1
U2 8
PU NATL INST SCIENCE COMMUNICATION-NISCAIR
PI NEW DELHI
PA DR K S KRISHNAN MARG, PUSA CAMPUS, NEW DELHI 110 012, INDIA
SN 0019-5189
EI 0975-1009
J9 INDIAN J EXP BIOL
JI Indian J. Exp. Biol.
PD AUG
PY 2023
VL 61
IS 8
BP 640
EP 645
DI 10.56042/ijeb.v61i08.3879
PG 6
WC Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics
GA O5QU6
UT WOS:001044362200006
OA gold
DA 2025-06-11
ER

PT J
AU Casanova, A
   Wevers, A
   Navarro-Ledesma, S
   Pruimboom, L
AF Casanova, Amaloha
   Wevers, Anne
   Navarro-Ledesma, Santiago
   Pruimboom, Leo
TI Mitochondria: It is all about energy
SO FRONTIERS IN PHYSIOLOGY
LA English
DT Review
DE mitochondria; mitochondrial dysfunction; mitochondrial metabolism;
   mitochondrial hormesis; hormesis
ID RESPIRATORY-CHAIN SUPERCOMPLEXES; CANCER A549 CELLS; 40 DEGREES-C;
   GUT-MICROBIOTA; INTERMITTENT HYPOXIA; INSULIN-RESISTANCE;
   ADIPOSE-TISSUE; SIGNALING PATHWAYS; AEROBIC GLYCOLYSIS; METABOLIC
   SYNDROME
AB Mitochondria play a key role in both health and disease. Their function is not limited to energy production but serves multiple mechanisms varying from iron and calcium homeostasis to the production of hormones and neurotransmitters, such as melatonin. They enable and influence communication at all physical levels through interaction with other organelles, the nucleus, and the outside environment. The literature suggests crosstalk mechanisms between mitochondria and circadian clocks, the gut microbiota, and the immune system. They might even be the hub supporting and integrating activity across all these domains. Hence, they might be the (missing) link in both health and disease. Mitochondrial dysfunction is related to metabolic syndrome, neuronal diseases, cancer, cardiovascular and infectious diseases, and inflammatory disorders. In this regard, diseases such as cancer, Alzheimer's, Parkinson's, amyotrophic lateral sclerosis (ALS), chronic fatigue syndrome (CFS), and chronic pain are discussed. This review focuses on understanding the mitochondrial mechanisms of action that allow for the maintenance of mitochondrial health and the pathways toward dysregulated mechanisms. Although mitochondria have allowed us to adapt to changes over the course of evolution, in turn, evolution has shaped mitochondria. Each evolution-based intervention influences mitochondria in its own way. The use of physiological stress triggers tolerance to the stressor, achieving adaptability and resistance. This review describes strategies that could recover mitochondrial functioning in multiple diseases, providing a comprehensive, root-cause-focused, integrative approach to recovering health and treating people suffering from chronic diseases.
C1 [Casanova, Amaloha; Wevers, Anne; Navarro-Ledesma, Santiago] Univ Granada, Dept Physiotherapy, Granada, Spain.
   [Casanova, Amaloha; Wevers, Anne; Navarro-Ledesma, Santiago] Fac Hlth Sci, Melilla, Spain.
   [Casanova, Amaloha; Wevers, Anne; Navarro-Ledesma, Santiago; Pruimboom, Leo] PNI Europe, The Hague, Netherlands.
   [Casanova, Amaloha; Wevers, Anne; Navarro-Ledesma, Santiago; Pruimboom, Leo] Univ Granada, Chair Clin Psychoneuroimmunol, PNI Europe, Granada, Spain.
C3 University of Granada; University of Granada
RP Navarro-Ledesma, S (corresponding author), Univ Granada, Dept Physiotherapy, Granada, Spain.; Navarro-Ledesma, S (corresponding author), Fac Hlth Sci, Melilla, Spain.; Navarro-Ledesma, S (corresponding author), PNI Europe, The Hague, Netherlands.; Navarro-Ledesma, S (corresponding author), Univ Granada, Chair Clin Psychoneuroimmunol, PNI Europe, Granada, Spain.
EM snl@ugr.es
RI Navarro-Ledesma, Santiago/K-5660-2017
FU chair of Clinical Psychoneuroimmunology
FX The study was funded by the chair of Clinical Psychoneuroimmunology (the
   University of Granada and PNI Europe)
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NR 520
TC 100
Z9 104
U1 34
U2 132
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1664-042X
J9 FRONT PHYSIOL
JI Front. Physiol.
PD APR 25
PY 2023
VL 14
AR 1114231
DI 10.3389/fphys.2023.1114231
PG 37
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA F8GK7
UT WOS:000984675800001
PM 37179826
OA Green Published, gold
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Escobedo-Monge, MF
   Barrado, E
   Parodi-Román, J
   Escobedo-Monge, MA
   Marcos-Temprano, M
   Marugán-Miguelsanz, JM
AF Escobedo-Monge, Marlene Fabiola
   Barrado, Enrique
   Parodi-Roman, Joaquin
   Escobedo-Monge, Maria Antonieta
   Marcos-Temprano, Marianela
   Marugan-Miguelsanz, Jose Manuel
TI Magnesium Status and Calcium/Magnesium Ratios in a Series of Cystic
   Fibrosis Patients
SO NUTRIENTS
LA English
DT Article
DE hypomagnesemia; hypermagnesemia; subclinical Mg deficiency
ID SERUM MAGNESIUM; METABOLIC SYNDROME; DIETARY MAGNESIUM; OXIDATIVE
   STRESS; VITAMIN-D; CALCIUM; CFTR; HYPOMAGNESEMIA; DEFICIENCY; PARAMETERS
AB Magnesium (Mg) is an essential micronutrient that participates in various enzymatic reactions that regulate vital biological functions. The main aim was to assess the Mg status and its association with nutritional indicators in seventeen cystic fibrosis (CF) patients. The serum Mg and calcium (Ca) levels were determined using standardized methods and the dietary Mg intake by prospective 72 h dietary surveys. The mean serum Ca (2.45 mmol/L) and Mg (0.82 mmol/L) had normal levels, and the mean dietary intake of the Ca (127% DRI: Dietary Reference Intake) and Mg (125% DRI) were high. No patients had an abnormal serum Ca. A total of 47% of the subjects had hypomagnesemia and 12% insufficient Mg consumption. One patient had a serum Mg deficiency and inadequate Mg intake. A total of 47 and 82% of our series had a high serum Ca/Mg ratio of >4.70 (mean 4.89) and a low Ca/Mg intake ratio of <1.70 (mean 1.10), respectively. The likelihood of a high Ca/Mg ratio was 49 times higher in patients with a serum Mg deficiency than in normal serum Mg patients. Both Ca/Mg ratios were associated with the risk of developing cardiovascular disease (CVD), type 2 diabetes (T2D), metabolic syndrome (MetS), and even several cancers. Therefore, 53% of the CF patients were at high risk of a Mg deficiency and developing other chronic diseases.
C1 [Escobedo-Monge, Marlene Fabiola; Marugan-Miguelsanz, Jose Manuel] Univ Valladolid, Dept Pediat, Fac Med, Avenida Ramon & Cajal 7, Valladolid 47005, Spain.
   [Barrado, Enrique] Univ Valladolid, Fac Sci, Dept Analyt Chem, Campus Miguel Delibes,Calle Paseo Belen, Valladolid 47011, Spain.
   [Parodi-Roman, Joaquin] Univ Cadiz, Fac Sci, Paseo Carlos III,28, Cadiz 11003, Spain.
   [Escobedo-Monge, Maria Antonieta] Univ Burgos, Fac Sci, Dept Chem, Plaza Misael Banuelos SN, Burgos 09001, Spain.
   [Marcos-Temprano, Marianela] Univ Clin Hosp Valladolid, Serv Pediat, Ave Ramon & Cajal 3, Valladolid 47005, Spain.
   [Marugan-Miguelsanz, Jose Manuel] Univ Clin Hosp Valladolid, Sect Gastroenterol & Pediat Nutr, Ave Ramon & Cajal 3, Valladolid 47003, Spain.
C3 Universidad de Valladolid; Universidad de Valladolid; Universidad de
   Cadiz; Universidad de Burgos
RP Escobedo-Monge, MF (corresponding author), Univ Valladolid, Dept Pediat, Fac Med, Avenida Ramon & Cajal 7, Valladolid 47005, Spain.
EM amescobedo@msn.com; ebarrado@qa.uva.es; joaquin_parodi@yahoo.es;
   antoitalia777@gmail.com; marianela_mt6@hotmail.com;
   jmmarugan@telefonica.net
RI ; ESCOBEDO MONGE, MARLENE FABIOLA/C-4830-2017
OI ESCOBEDO MONGE, MARIA ANTONIETA/0000-0001-6318-7333; Marcos,
   Marianela/0000-0002-2556-5089; ESCOBEDO MONGE, MARLENE
   FABIOLA/0000-0002-1295-3752
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NR 147
TC 9
Z9 9
U1 0
U2 6
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD MAY
PY 2022
VL 14
IS 9
AR 1793
DI 10.3390/nu14091793
PG 24
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 1F8OZ
UT WOS:000795422600001
PM 35565764
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Balaban, M
   Virgolici, B
   Dinu, A
   Totan, A
   Miricescu, D
   Stefan, D
   Greabu, M
   Mohora, M
AF Balaban, Mihaela
   Virgolici, Bogdana
   Dinu, Adriana
   Totan, Alexandra
   Miricescu, Daniela
   Stefan, Daciana
   Greabu, Maria
   Mohora, Maria
TI Metabolic Parameters in Wistar Rats Treated with Glucocorticosteroids
   and Vitamin E-Charged Poly Lactic-Co-Glycolic Acid (PLGA) Nanoparticles
SO REVISTA DE CHIMIE
LA English
DT Article
DE prednisone; vitamin E-charged PLGA nanoparticles; Wistar rats
ID INSULIN-RESISTANCE; LIPID-METABOLISM; ADIPOSE-TISSUE; LIVER;
   INFLAMMATION; STRESS
AB Glucocorticosteroids are the mainstay of treatment in many inflammatory and autoimmune disorders. Their administration can be associated with various side effects, similar to those within the metabolic syndrome. The beneficial effects of vitamin E in metabolic syndrome were demonstrated by many studies. Nowadays, vitamin E can be administrated through a new and innovative system delivery, such as polylactic-coglycolic acid nanoparticles (PLGA-NPs). The aim of this experimental study was to compare the metabolic and haematological parameters after Prednisone administration as a single drug or in combination with vitamin E delivered by PLGA-NPs. Wistar male rats (n=15, age 10-12 months), on standard diet were randomised in three groups, for 6 weeks as: group SC served as a control, group SP was treated with Prednisone (1 mg/kg/day) by oral gavage and group SN received Prednisone (1 mg/kg/day) and vitamin E-charged PLGA nanoparticles (1 mg/kg/day) by oral gavage. In the Prednison treated group versus control, higher levels (p<0.05) were demonstrated for visceral fat weight, glycosylated hemoglobin (cholesterolemia and triglyceridemia. The association of PLGA-NPs charged with vitamin E to Prednisone prevented (p<0.05) hypercholesterolemia and visceral fat development induced by the cortisol intake. In conclusion, polylactic-co-glycolic acid nanoparticles (PLGA-NPs) charged with Vitamin E may demonstrate promising results in decreasing side effects induced by glucocorticosteroids, by reducing the amount of visceral fat and cholesterolemia.
C1 [Balaban, Mihaela; Virgolici, Bogdana; Dinu, Adriana; Totan, Alexandra; Miricescu, Daniela; Stefan, Daciana; Greabu, Maria; Mohora, Maria] Carol Davila Univ Med & Pharm, Biochem Dept, 8 Eroilor Sanitari, Bucharest 050474, Romania.
C3 Carol Davila University of Medicine & Pharmacy
RP Virgolici, B (corresponding author), Carol Davila Univ Med & Pharm, Biochem Dept, 8 Eroilor Sanitari, Bucharest 050474, Romania.
EM hvirgolici@yahoo.com
RI Ripszky-Totan, Alexandra/JTT-4320-2023; Daniela, Miricescu/G-8788-2016;
   Virgolici, Bogdana/MTF-9331-2025; Greabu, Maria/Q-9336-2019
OI Ripszky, Alexandra/0000-0002-4345-282X
CR Alcalá M, 2015, OBESITY, V23, P1598, DOI 10.1002/oby.21135
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NR 28
TC 2
Z9 2
U1 0
U2 5
PU CHIMINFORM DATA S A
PI BUCHAREST
PA CALEA PLEVNEI NR 139, SECTOR 6, BUCHAREST R-77131, ROMANIA
SN 0034-7752
J9 REV CHIM-BUCHAREST
JI Rev. Chim.
PD APR
PY 2019
VL 70
IS 4
BP 1315
EP 1318
PG 4
WC Chemistry, Multidisciplinary; Engineering, Chemical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Engineering
GA IA2JK
UT WOS:000469387200042
DA 2025-06-11
ER

PT J
AU Park, YC
   Kim, J
   Seo, MS
   Hong, SW
   Cho, ES
   Kim, JK
AF Park, Yon Chul
   Kim, Jin
   Seo, Min Seok
   Hong, Sung Won
   Cho, Eun Seok
   Kim, Jong-Koo
TI Inverse relationship between vitamin D levels and platelet indices in
   Korean adults
SO HEMATOLOGY
LA English
DT Article
DE Mean platelet volumes; platelet count; vitamin D
ID CORONARY-ARTERY CALCIFICATION; 25-HYDROXYVITAMIN D; MEDITERRANEAN DIET;
   METABOLIC SYNDROME; ENDOTHELIAL-CELLS; HYPOVITAMINOSIS D; OXIDATIVE
   STRESS; VOLUME; INFLAMMATION; OBESITY
AB Background and aims: Vitamin D deficiency and increased platelet indices are associated with increased rate or risk of several diseases such as cardiovascular disease and metabolic syndrome, respectively. We investigated whether vitamin D deficiency is associated with increased platelet count (PC) and mean platelet volume (MPV).
   Methods and results: The study included 3190 subjects older than 20 years. Subjects were divided into three groups based on their vitamin D levels: vitamin D deficiency (< 10.0 ng/ml); insufficiency (10-20 ng/ml); and sufficiency (> 20.0 ng/ml). The associations between platelet indices and various parameters were analyzed by Pearson's correlation analysis and t-tests. Then, multivariate linear regression analyses were done correcting for associated parameters. PC and MPV showed a negative correlation with vitamin D groups by ANOVA and multiple linear regression. PC was inversely related with vitamin D group after adjusting for sex, age, regular exercise, white blood cell count, total cholesterol, hemoglobin, and creatinine levels (beta +/- SE =-3.461 +/- 1.512, P = 0.022). MPV was also inversely related with vitamin D group after adjusting for regular exercise, hemoglobin level, and total cholesterol level (beta +/- SE= -0.080 +/- 0.026, P = 0.002), and this relationship remained statistically significant after adjusting for regular exercise, hemoglobin level, total cholesterol level, diabetes, hypertension, and body mass index (beta +/- SE=-0.082 +/- 0.026, P = 0.002).
   Conclusion: PC and MPV are inversely associated with vitamin D levels in adults.
C1 [Park, Yon Chul; Kim, Jin; Cho, Eun Seok; Kim, Jong-Koo] Yonsei Univ, Wonju Coll Med, Dept Family Med, 162 Ilsan Dong, Wonju, South Korea.
   [Seo, Min Seok; Hong, Sung Won] Yonsei Univ, Coll Med, Gangnam Severance Hosp, Dept Family Med, Seoul, South Korea.
C3 Yonsei University; Yonsei University; Yonsei University Health System
RP Kim, JK (corresponding author), Yonsei Univ, Wonju Coll Med, Dept Family Med, 162 Ilsan Dong, Wonju, South Korea.
EM kimjk214@yonsei.ac.kr
RI Seo, Minseok/JXM-0791-2024; Lee, JongGu/B-7384-2013
OI Park, Yon Chul/0000-0002-1787-0884; Seo, Minseok/0000-0001-5551-4891
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NR 39
TC 28
Z9 28
U1 1
U2 4
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1024-5332
EI 1607-8454
J9 HEMATOLOGY
JI Hematology
PY 2017
VL 22
IS 10
BP 623
EP 629
DI 10.1080/10245332.2017.1318334
PG 7
WC Hematology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Hematology
GA FT6XT
UT WOS:000423297900007
PM 28486836
OA gold
DA 2025-06-11
ER

PT J
AU Nguyen, TTA
   Nishitani, M
   Harada, S
   Yamaguchi, M
   Kamei, K
AF Nguyen Thi Tu Anh
   Nishitani, Maiko
   Harada, Shigeharu
   Yamaguchi, Masamitsu
   Kamei, Kaeko
TI A Drosophila model for the screening of bioavailable NADPH oxidase
   inhibitors and antioxidants
SO MOLECULAR AND CELLULAR BIOCHEMISTRY
LA English
DT Article
DE NADPH oxidase; Drosophila melanogaster; Metabolic syndrome model;
   Screening; Antioxidant; NADPH oxidase inhibitor
ID METABOLIC SYNDROME; OXIDATIVE STRESS; GENE-EXPRESSION; DEFICIENT MICE;
   QUERCETIN; ABSORPTION; GLYCOSIDES; FAMILY
AB NADPH oxidase is the major source of non-mitochondrial cellular reactive oxygen species (ROS), and also is reported to be a major cause of various diseases including atherosclerosis and hypertension. In order to screen a new curative reagent that can suppress NADPH oxidase activity, we developed a Drosophila melanogaster fly that would overexpress human Dual oxidase 2 (hDuox2), a member of the NADPH oxidase family, as a screening model. These flies (GMR-GAL4/UAS-hDuox2) had a high generation of ROS in the posterior region of the eye discs along with an easily recognizable rough-eye phenotype, which is an ideal and convenient marker for further screening steps. Moreover, the hDuox2-induced rough-eye phenotype can be rescued by feeding with a culture medium containing mulberry leaves (MLs), which reportedly have an antimetabolic effect. Some commercially available antioxidants such as quercetin-3-O-d-glucoside or quercetin-3-O-glucose-6''-acetate, or the naringin contained in MLs and other herbs, also have shown a similar suppressing effect on the rough-eye phenotype. Our results suggest that flavonoid glycoside is absorbed from the intestine and functions in the body of D. melanogaster as it does in mammalian models such as rats. Thus, the GMR-GAL4/UAS-hDuox2 fly line is a promising model for the screening of novel drugs such as NADPH oxidase inhibitors and/or antioxidants.
C1 [Nguyen Thi Tu Anh; Nishitani, Maiko; Harada, Shigeharu; Yamaguchi, Masamitsu; Kamei, Kaeko] Kyoto Inst Technol, Dept Appl Biol, Sakyo Ku, Kyoto 6068585, Japan.
C3 Kyoto Institute of Technology
RP Kamei, K (corresponding author), Kyoto Inst Technol, Dept Appl Biol, Sakyo Ku, Kyoto 6068585, Japan.
EM kame@kit.ac.jp
OI Yamaguchi, Masamitsu/0000-0002-6321-9750
FU Grants-in-Aid for Scientific Research [22241052] Funding Source: KAKEN
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NR 21
TC 12
Z9 12
U1 0
U2 19
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0300-8177
J9 MOL CELL BIOCHEM
JI Mol. Cell. Biochem.
PD JUN
PY 2011
VL 352
IS 1-2
BP 91
EP 98
DI 10.1007/s11010-011-0743-3
PG 8
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA 765FJ
UT WOS:000290688500011
PM 21312054
DA 2025-06-11
ER

PT J
AU Lee, Y
   Chakraborty, S
   Muthuchamy, M
AF Lee, Yang
   Chakraborty, Sanjukta
   Muthuchamy, Mariappan
TI Roles of sarcoplasmic reticulum Ca<SUP>2+</SUP> ATPase pump in the
   impairments of lymphatic contractile activity in a metabolic syndrome
   rat model
SO SCIENTIFIC REPORTS
LA English
DT Article
ID MASSIVE LOCALIZED LYMPHEDEMA; CHAIN 20 PHOSPHORYLATION; SKELETAL-MUSCLE;
   PRACTICAL GUIDE; SMOOTH-MUSCLE; SERCA; INFLAMMATION; STRESS;
   CA2+-ATPASE; DYSFUNCTION
AB The intrinsic lymphatic contractile activity is necessary for proper lymph transport. Mesenteric lymphatic vessels from high-fructose diet-induced metabolic syndrome (MetSyn) rats exhibited impairments in its intrinsic phasic contractile activity; however, the molecular mechanisms responsible for the weaker lymphatic pumping activity in MetSyn conditions are unknown. Several metabolic disease models have shown that dysregulation of sarcoplasmic reticulum Ca2+ ATPase (SERCA) pump is one of the key determinants of the phenotypes seen in various muscle tissues. Hence, we hypothesized that a decrease in SERCA pump expression and/or activity in lymphatic muscle influences the diminished lymphatic vessel contractions in MetSyn animals. Results demonstrated that SERCA inhibitor, thapsigargin, significantly reduced lymphatic phasic contractile frequency and amplitude in control vessels, whereas, the reduced MetSyn lymphatic contractile activity was not further diminished by thapsigargin. While SERCA2a expression was significantly decreased in MetSyn lymphatic vessels, myosin light chain 20, MLC20 phosphorylation was increased in these vessels. Additionally, insulin resistant lymphatic muscle cells exhibited elevated intracellular calcium and decreased SERCA2a expression and activity. The SERCA activator, CDN 1163 partially restored lymphatic contractile activity in MetSyn lymphatic vessel by increasing phasic contractile frequency. Thus, our data provide the first evidence that SERCA2a modulates the lymphatic pumping activity by regulating phasic contractile amplitude and frequency, but not the lymphatic tone. Diminished lymphatic contractile activity in the vessels from the MetSyn animal is associated with the decreased SERCA2a expression and impaired SERCA2 activity in lymphatic muscle.
C1 [Lee, Yang; Chakraborty, Sanjukta; Muthuchamy, Mariappan] Texas A&M Univ, Coll Med, Dept Med Physiol, Bryan, TX 77807 USA.
   [Lee, Yang] Harvard Med Sch, Boston Childrens Hosp, Vasc Biol Program, Boston, MA 02115 USA.
C3 Texas A&M University System; Texas A&M University College Station;
   Harvard University; Harvard University Medical Affiliates; Boston
   Children's Hospital; Harvard Medical School
RP Muthuchamy, M (corresponding author), Texas A&M Univ, Coll Med, Dept Med Physiol, Bryan, TX 77807 USA.
EM marim@tamu.edu
OI Chakraborty, Sanjukta/0000-0002-4869-3198
FU U.S. National Institutes of Health, National Institute of Diabetes and
   Digestive and Kidney Diseases [RO1 DK99221]; Department of Medical
   Physiology, Lymphatic Graduate Student Fellowship
FX The authors thank the Texas A&M Health Science Center Integrated
   Microscopy and Imaging Laboratory and Histology core facility at the
   department of Medical Physiology. We thank David Zawieja, Ph.D. and his
   lab members, Wei Wang, M.D. and Olga Gasheva, M.D., and Anatoliy Gashev,
   M.D., Ph.D. for assisting with lymphatic functional studies. We also
   thank Dr. Cristine Heaps, Ph.D. and Jeffery Bray for technical assistant
   for calcium measurements. The authors thank Drs. Cynthia J. Meininger
   and Brett M. Mitchell for advice and proofreading. This work was
   supported by U.S. National Institutes of Health, National Institute of
   Diabetes and Digestive and Kidney Diseases Grant RO1 DK99221 (to M.M.)
   and Department of Medical Physiology, Lymphatic Graduate Student
   Fellowship (to Y.L.).
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NR 82
TC 15
Z9 17
U1 0
U2 5
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD JUL 23
PY 2020
VL 10
IS 1
AR 12320
DI 10.1038/s41598-020-69196-4
PG 20
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA MV9TL
UT WOS:000556690900027
PM 32704072
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Moriyama, K
   Takahashi, E
AF Moriyama, Kengo
   Takahashi, Eiko
TI Evaluation of Malondialdehyde Low-Density Lipoprotein Stratified by
   Low-Density Lipoprotein Cholesterol
SO CLINICAL LABORATORY
LA English
DT Article
DE MDA-LDL; LDL-C; HDL-C; metabolic syndrome; annual health examination
ID CORONARY-ARTERY-DISEASE; CIRCULATING OXIDIZED LDL; PLASMA-LIPOPROTEINS;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; OXIDATIVE STRESS; MEN;
   ASSOCIATION; HDL; ATHEROSCLEROSIS
AB Background: Malondialdehyde low-density lipoprotein (MDA-LDL) is a major form of oxidized LDL and considered to be more atherogenic than LDL. Information on major determinants of MDA-LDL and their association in subjects who are not under treatment for diabetes mellitus and dyslipidemia is limited.
   Methods: This study included 778 Japanese subjects who were not taking medication for diabetes mellitus and dyslipidemia. All subjects underwent an annual health examination that included MDA-LDL analysis. Study subjects were divided into four groups according to mean values of LDL-C and MDA-LDL, and the metabolic profile was compared.
   Results: LDL cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) were mainly associated with MDA-LDL. When subjects were stratified based on LDL-C levels, small dense LDL-C and MDA-LDL levels increased as LDL-C levels increased. Comparison of the characteristics of study subjects in the same LDL-C level group revealed that subjects with high MDA-LDL showed high metabolic risk in all LDL-C groups, particularly notable in the group with LDL-C levels < 120 mg/dL.
   Conclusions: Our data indicated that high LDL-C and low HDL-C levels were independently associated with high MDA-LDL. To prevent high MDA-LDL, it is important to lower LDL-C level as well as to increase HDL-C even in subjects with low LDL-C level by lifestyle modification.
C1 [Moriyama, Kengo; Takahashi, Eiko] Tokai Univ, Sch Med, Dept Clin Hlth Sci, 1838 Ishikawa Machi, Hachioji, Tokyo 1920032, Japan.
C3 Tokai University
RP Takahashi, E (corresponding author), Tokai Univ, Sch Med, Dept Clin Hlth Sci, 1838 Ishikawa Machi, Hachioji, Tokyo 1920032, Japan.; Takahashi, E (corresponding author), Tokai Univ, Hachioji Hosp, Hlth Evaluat & Promot Ctr, Hachioji, Tokyo, Japan.
EM etaka@tokai.ac.jp
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NR 40
TC 6
Z9 6
U1 0
U2 1
PU CLIN LAB PUBL
PI HEIDELBERG
PA IM BREITSPIEL 15, HEIDELBERG, D-69126, GERMANY
SN 1433-6510
J9 CLIN LAB
JI Clin. Lab.
PY 2017
VL 63
IS 7-8
BP 1179
EP 1186
DI 10.7754/Clin.Lab.2017.170113
PG 8
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA FD4WB
UT WOS:000407531800017
PM 28792690
DA 2025-06-11
ER

PT J
AU Ackerman, Z
   Skarzinski, G
   Grozovski, M
   Oron-Herman, M
   Sela, BA
AF Ackerman, Zvi
   Skarzinski, Galina
   Grozovski, Maria
   Oron-Herman, Mor
   Sela, Ben-Ami
TI R1: Effects of Antihypertensive and Triglyceride-lowering Agents on
   Hepatic Copper Concentrations in Rats with Fatty Liver Disease
SO BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
LA English
DT Article
ID GENE-EXPRESSION; METABOLIC SYNDROME; NONALCOHOLIC STEATOHEPATITIS;
   MICROARRAY ANALYSIS; OXIDATIVE STRESS; FRUCTOSE; DEFICIENCY; DIET;
   METALLOTHIONEIN; BEZAFIBRATE
AB Copper deficiency had been suggested to link between fructose-enriched diet (FED) and the development of non-alcoholic fatty liver disease (NAFLD). In this study, we characterized changes in hepatic copper concentrations and hepatic oxidative milieu, in rats with the metabolic syndrome and NAFLD as a result of FED with pharmacological manipulations to reduce blood pressure or plasma triglycerides. Changes in plasma and hepatic copper concentrations were correlated with changes observed in the immunohistochemical hepatic expression of copper-zinc-superoxide dismutase (CuZnSOD; SOD1), metallothionein (MT) and nitrotyrosine (NITT). FED administration was associated with a 2.2-fold reduction in hepatic copper concentrations, a decrease in the hepatic SOD1 expression, disappearance of the hepatic MT expression and increase in the hepatic NITT expression. Bezafibrate administration restored the hepatic copper concentrations and the hepatic SOD1 expression to levels that were observed in the control rats. A significant positive correlation between hepatic copper concentrations and the values of hepatic SOD1 expression of each animal included in this study was found. Administration of either captopril or bezafibrate increased hepatic MT expression, however, to levels that were lower than those observed in the control group. Administration of either amlodipine, or captopril or bezafibrate to the FED rats, had no effect on hepatic NITT expression. NAFLD development in FED rats is associated with a decrease in hepatic copper concentrations that is associated with a decrease in the hepatic SOD1 expression. Bezafibrate administration increases hepatic copper concentrations and restores the hepatic SOD1 expression.
C1 [Ackerman, Zvi; Skarzinski, Galina] Hadassah Hebrew Univ, Dept Med, Med Ctr, IL-91240 Jerusalem, Israel.
   [Grozovski, Maria] Ort Braude Coll Engn, Karmiel, Israel.
   [Oron-Herman, Mor; Sela, Ben-Ami] Chaim Sheba Med Ctr, Inst Chem Pathol, IL-52621 Tel Hashomer, Israel.
C3 Hebrew University of Jerusalem; Hadassah University Medical Center;
   Braude Academic College of Engineering; Chaim Sheba Medical Center
RP Ackerman, Z (corresponding author), Hadassah Hebrew Univ, Dept Med, Med Ctr, Mt Scopus Campus,POB 24035, IL-91240 Jerusalem, Israel.
EM zackerman@hadassah.org.il
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NR 37
TC 4
Z9 5
U1 0
U2 5
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-7835
EI 1742-7843
J9 BASIC CLIN PHARMACOL
JI Basic Clin. Pharmacol. Toxicol.
PD DEC
PY 2014
VL 115
IS 6
BP 545
EP 551
DI 10.1111/bcpt.12283
PG 7
WC Pharmacology & Pharmacy; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Toxicology
GA AU0WC
UT WOS:000345341900010
PM 24975050
DA 2025-06-11
ER

PT J
AU Lee, HY
   Sakuma, I
   Ihm, SH
   Goh, CW
   Koh, KK
AF Lee, Hae-Young
   Sakuma, Ichiro
   Ihm, Sang-Hyun
   Goh, Choong-Won
   Koh, Kwang Kon
TI Statins and Renin-Angiotensin System Inhibitor Combination Treatment to
   Prevent Cardiovascular Disease
SO CIRCULATION JOURNAL
LA English
DT Review
DE Cardiovascular disease; Hypercholesterolemia; Hypertension;
   Renin-angiotensin system inhibitors; Statins
ID CONVERTING ENZYME-INHIBITORS; CAUSES INSULIN-RESISTANCE; TYPE-2
   DIABETES-MELLITUS; KOREAN NATIONAL-HEALTH; METABOLIC SYNDROME; RECEPTOR
   BLOCKER; COMBINED THERAPY; RECIPROCAL RELATIONSHIPS; ENDOTHELIAL
   DYSFUNCTION; OXIDATIVE STRESS
AB Hypercholesterolemia and hypertension are common risk factors for cardiovascular disease (CVD). Updated guidelines emphasize target reductions of overall cardiovascular risks. Experimental studies have shown reciprocal relationships between insulin resistance (IR) and endothelial dysfunction. Hypercholesterolemia and hypertension have a synergistic deleterious effect on IR and endothelial dysfunction. Unregulated renin-angiotensin system (RAS) is important in the pathogenesis of atherosclerosis and hypertension. Various strategies with different classes of antihypertensive medications to reach target goals have failed to reduce residual CVD risk further. Of interest, treating moderate cholesterol elevations with low-dose statins in hypertensive patients reduced CVD risk by 35-40% further. Therefore, statins are important in reducing CVD risk. Unfortunately, statin therapy causes IR and increases the risk of type 2 diabetes mellitus. RAS inhibitors improve both endothelial dysfunction and IR. Further, cross-talk between hypercholesterolemia and RAS exists at multiple steps of IR and endothelial dysfunction. In this regard, combined therapy with statins and RAS inhibitors demonstrates additive/synergistic effects on endothelial dysfunction and IR in addition to lowering cholesterol levels and blood pressure when compared with either monotherapy in patients. This is mediated by both distinct and interrelated mechanisms. Therefore, combined therapy with statins and RAS inhibitors may be important in developing optimal management strategies in patients with hypertension, hypercholesterolemia, diabetes, metabolic syndrome, or obesity to prevent CVD.
C1 [Lee, Hae-Young] Seoul Natl Univ, Coll Med, Div Cardiol, Seoul, South Korea.
   [Ihm, Sang-Hyun] Catholic Univ Korea, Coll Med, Div Cardiol, Seoul, South Korea.
   [Goh, Choong-Won] Inje Univ, Sanggyepaik Hosp, Dept Cardiol, Seoul, South Korea.
   [Koh, Kwang Kon] Gachon Univ, Gil Hosp, Div Cardiol, Inchon 405760, South Korea.
   [Koh, Kwang Kon] Gachon Cardiovasc Res Inst, Inchon, South Korea.
   [Sakuma, Ichiro] Hokko Mem Clin, Sapporo, Hokkaido, Japan.
C3 Seoul National University (SNU); Catholic University of Korea; Inje
   University; Gachon University; Gachon University
RP Koh, KK (corresponding author), Gachon Univ, Gil Hosp, Div Cardiol, Vasc Med & Atherosclerosis Unit, 1198 Kuwol Dong, Inchon 405760, South Korea.
EM kwangk@gilhospital.com
RI Lee, Hye-Young/JEP-8044-2023
OI Lee, Hae-Young/0000-0002-9521-4102; Sakuma, Ichiro/0000-0002-3863-0492;
   Ihm, Sang Hyun/0000-0001-5017-5421
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NR 67
TC 40
Z9 43
U1 1
U2 26
PU JAPANESE CIRCULATION SOC
PI TOYKO
PA 18TH FLOOR IMPERIAL HOTEL TOWER, 1-1-1 UCHISAIWAI-CHO CHIYODA-KU, TOYKO,
   100-0011, JAPAN
SN 1346-9843
EI 1347-4820
J9 CIRC J
JI Circ. J.
PD FEB
PY 2014
VL 78
IS 2
BP 281
EP 287
DI 10.1253/circj.CJ-13-1494
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 299UX
UT WOS:000330422300002
PM 24401609
OA gold
DA 2025-06-11
ER

PT J
AU Zhao, L
   Shen, YJ
   Wang, YL
   Wang, L
   Zhang, L
   Zhao, ZJ
   Li, SY
AF Zhao, Lei
   Shen, Yunjiao
   Wang, Yunlong
   Wang, Lei
   Zhang, Lin
   Zhao, Zijian
   Li, Shengyu
TI Lactobacillus plantarum S9 alleviates lipid profile, insulin
   resistance, and inflammation in high-fat diet-induced metabolic syndrome
   rats
SO SCIENTIFIC REPORTS
LA English
DT Article
ID OXIDATIVE STRESS; OBESITY; MICE; MICROBIOTA
AB Probiotics are considered to play an crucial role in the treatment of high-fat diet (HFD)-induced lipid metabolic diseases, including metabolic syndrome (MS). This study aimed to investigate the effects of Lactobacillus plantarum S9 on MS in HFD-fed rats, and to explore the underlying role of probiotics in the treatment of MS. Sprague-Dawley rats were fed with HFD for 8 weeks, followed by the treatment of L. plantarum S9 for 6 weeks, and The body weight and blood glucose level of rats were detected on time. The results showed that L. plantarum S9 significantly decreased the body weight gain, Lee's index, and liver index. Additionally, L. plantarum S9 reduced the levels of serum lipids and insulin resistance. L. plantarum S9 also decreased the levels of alanine aminotransferase (ALT) and aspartate transaminase (AST) in liver. Moreover, the serum levels of MS-related inflammatory signaling molecules, including lipopolysaccharide (LPS) and tumor necrosis factor-alpha (TNF-alpha), were significantly elevated. Western blot analysis showed that L. plantarum S9 inhibited the activation of nuclear factor-kappa B (NF-kappa B) pathway, decreased the expression level of Toll-like receptor 4 (TLR4), suppressed the activation of inflammatory signaling pathways, and reduced the expression levels of inflammatory factors in HFD-fed rats. Moreover, it further decreased the ratios of p-I kappa B alpha/I kappa B alpha, p-p65/NF-kappa B p65, and p-p38/p38. In summary, L. plantarum S9, as a potential functional strain, prevents or can prevent onset of MS.
C1 [Zhao, Lei; Shen, Yunjiao; Wang, Lei] Changchun Univ Chinese Med, Sch Pharmaceut Sci, Changchun 130117, Peoples R China.
   [Wang, Yunlong] Giant Praise JILIN Pharmaceut Co LTD, Changchun 130033, Peoples R China.
   [Zhang, Lin; Zhao, Zijian; Li, Shengyu] Jilin Acad Agr Sci, Inst Agr Prod Proc Technol, Natl R&D Ctr Milk Proc, Changchun 130033, Peoples R China.
C3 Changchun University of Chinese Medicine; Jilin Academy of Agricultural
   Sciences
RP Li, SY (corresponding author), Jilin Acad Agr Sci, Inst Agr Prod Proc Technol, Natl R&D Ctr Milk Proc, Changchun 130033, Peoples R China.
EM lisy720@126.com
RI Wang, Yunlong/ABC-2186-2022; Zhao, Zijian/N-1171-2018
FU China Agriculture Research System of MOF and MARA; 2021 Jilin Province
   Science and Technology Development Plan [20210101424JC]
FX This work was funded by China Agriculture Research System of MOF and
   MARA and 2021 Jilin Province Science and Technology Development Plan
   (20210101424JC).
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NR 43
TC 22
Z9 23
U1 2
U2 19
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD SEP 15
PY 2022
VL 12
IS 1
AR 15490
DI 10.1038/s41598-022-19839-5
PG 10
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 4O6GZ
UT WOS:000854795200041
PM 36109620
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Van Winkle, LJ
AF Van Winkle, Lon J.
TI Perspective: One-Cell and Cleavage-Stage Mouse Embryos Thrive in
   Hyperosmotic Oviductal Fluid Through Expression of a Glycine
   Neurotransmitter Transporter and a Glycine-Gated Chloride Channel:
   Clinical and Transgenerational Implications
SO FRONTIERS IN PHYSIOLOGY
LA English
DT Article
DE ART; embryo; epigenetic modifications; glycine; GLYT1; GLRA4; metabolic
   syndrome; oviductal fluid
ID VOLUME REGULATION; PREIMPLANTATION; OOCYTES; STRESS; EGGS
AB The osmolality of mouse oviductal fluid ranges from about 300 mOsmol/kg in the ampulla 0-3 h post coitus (h p.c.) to more than 350 mOsmol/kg in the isthmus 34-36 h p.c. Thus, it has been surprising to find that development of one-cell and cleavage-stage mouse embryos arrests in vitro in media exceeding 300 mOsmol/kg, and they develop best in unphysiological, hypotonic media. The glycine concentration in oviductal fluid can, however, rescue development in hypertonic media, so physiological conditions in vivo and in vitro likely work together to foster embryo well-being. Glycine acts on one-cell and cleavage-stage mouse embryos through the glycine-gated chloride channel, GLRA4, and uptake via the glycine neurotransmitter transporter, GLYT1. Since these processes lead to further signaling in neurons, the presence and function of such signaling in preimplantation embryos also should be investigated. The more we know about the interactions of physiological processes and conditions in vivo, the better we would be able to reproduce them in vitro. Such improvements in assisted reproductive technology (ART) could improve patient outcomes for IVF and potentially help prevent unwanted developmental abnormalities in early embryos, which might include undesirable epigenetic DNA and histone modifications. These epigenetic modifications may lead to transgenerational adult disorders such as metabolic syndrome and related conditions.
C1 [Van Winkle, Lon J.] Midwestern Univ, Dept Biochem, Downers Grove, IL 60515 USA.
   [Van Winkle, Lon J.] Rocky Vista Univ, Dept Med Humanities, Parker, CO 80134 USA.
C3 Midwestern University; Midwestern University - Downers Grove
RP Van Winkle, LJ (corresponding author), Midwestern Univ, Dept Biochem, Downers Grove, IL 60515 USA.; Van Winkle, LJ (corresponding author), Rocky Vista Univ, Dept Med Humanities, Parker, CO 80134 USA.
EM lvanwinkle@rvu.edu
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NR 34
TC 5
Z9 5
U1 2
U2 3
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1664-042X
J9 FRONT PHYSIOL
JI Front. Physiol.
PD DEC 21
PY 2020
VL 11
AR 613840
DI 10.3389/fphys.2020.613840
PG 5
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA PN2MB
UT WOS:000604317700001
PM 33408644
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Shoar, Z
   Goldenthal, MJ
   De Luca, F
   Suarez, E
AF Shoar, Zohreh
   Goldenthal, Michael J.
   De Luca, Francesco
   Suarez, Elizabeth
TI Mitochondrial DNA content and function, childhood obesity, and insulin
   resistance
SO ENDOCRINE RESEARCH
LA English
DT Article
DE Childhood obesity; mitochondrial content; mitochondrial function;
   mitochondrial respiratory complexes
ID OXIDATIVE STRESS; PROTEIN-SYNTHESIS; ADIPOSE-TISSUE; COPY NUMBER;
   MUSCLE; INFLAMMATION; DYSFUNCTION; INCREASE; DISEASE; GLUCOSE
AB Objectives: The objectives of our study were to compare the mitochondrial enzyme activity between obese and non-obese children and to assess the association between mitochondrial DNA content and function and markers of metabolic syndrome. Methods: Clinical and anthropometric data of obese and normal-weight children ages 2-18 years were collected. We collected buccal swabs for mitochondrial respiratory enzymes (complex I, IV, and Citrate Synthase). In obese children only, serum levels of metabolic parameters and mitochondrial DNA from mononuclear cells were quantitated. Results: We recruited 75 obese and 65 normal-weight children. There was no difference in respiratory complex enzyme activity levels between obese and normal-weight subjects. In obese subjects, mitochondrial to nuclear DNA (mt/nDNA) ratio was significantly correlated with BMI Z-score and BMI percentile (p<0.05, and p<0.01, respectively), and the strength of this correlation was proportionate to the degree of obesity. We did not find any association between mt/nDNA ratio and metabolic parameters. We observed a significant positive association between complex IV activity and fasting insulin level (p<0.05). Finally, fasting insulin explained 45% of the variation in the complex IV activity level (p<0.05). Conclusion: Our findings indicate that mitochondrial DNA content is directly related to obesity, but not to the markers of metabolic syndrome/insulin resistance in children. Longitudinal studies involving larger samples are needed to confirm our findings and help elucidate the relationship between mitochondrial function, adiposity, and insulin resistance.
C1 [Shoar, Zohreh; De Luca, Francesco; Suarez, Elizabeth] Drexel Univ, Sect Endocrinol & Diabet, Coll Med, St Christophers Hosp, Philadelphia, PA 19104 USA.
   [Goldenthal, Michael J.] Drexel Univ, Sect Child Neurol, Coll Med, St Christophers Hosp, Philadelphia, PA 19104 USA.
C3 Drexel University; Drexel University
RP Shoar, Z (corresponding author), St Christophers Hosp Children, Sect Endocrinol & Diabet, 3601 A St, Philadelphia, PA 19134 USA.
EM zshoar@gmail.com
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NR 49
TC 14
Z9 16
U1 0
U2 7
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 0743-5800
EI 1532-4206
J9 ENDOCR RES
JI Endocr. Res.
PD JAN 2
PY 2016
VL 41
IS 1
BP 49
EP 56
DI 10.3109/07435800.2015.1068797
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA DG4AT
UT WOS:000372013000008
PM 26513277
DA 2025-06-11
ER

PT J
AU Valencia, AP
   Schappal, AE
   Morris, EM
   Thyfault, JP
   Lowe, DA
   Spangenburg, EE
AF Valencia, Ana P.
   Schappal, Anna E.
   Morris, E. Matthew
   Thyfault, John P.
   Lowe, Dawn A.
   Spangenburg, Espen E.
TI The presence of the ovary prevents hepatic mitochondrial oxidative
   stress in young and aged female mice through glutathione peroxidase 1
SO EXPERIMENTAL GERONTOLOGY
LA English
DT Article
DE Ovariectomy; Mitochondrial function; Gpx1; Aging; Liver; Oxidative
   stress
ID MUSCLE INSULIN-RESISTANCE; FATTY LIVER-DISEASE; SKELETAL-MUSCLE;
   METABOLIC SYNDROME; OVARIECTOMIZED MICE; POSTMENOPAUSAL WOMEN;
   LIPID-ACCUMULATION; GENE-EXPRESSION; ADIPOSE-TISSUE; PROTEIN-KINASE
AB Background: For unknown reasons a woman's risk for developing Metabolic Syndrome (MetS) increases dramatically with age and/or loss of ovarian function. The MetS is characterized by hepatic insulin resistance (IR), which is strongly associated with intrahepatic lipid (IHL) accumulation, mitochondrial dysfunction, and oxidative stress. Although circumstantial evidence suggests that the endocrine function of the ovary can directly impact hepaticmitochondrial function, this hypothesis remains untested. Thus, the purpose of this study was to assess the influence of age and secretory function of the ovary on mechanisms that regulate hepatic mitochondrial function.
   Methods: Adult (10 week-old) and aged (88 week-old) female C57BL/6 mice were separated into two groups to undergo bilateral ovariectomy (OVX) or control surgery (SHAM). Eight weeks after surgery hepatic tissue was removed for measurements of total IHL and fatty acid species within hepatic triglycerides, mitochondrial function, and reactive oxygen species (ROS) production.
   Results: Hepatic IHL content was not affected by OVX, but was increased by age. OVX had no effect on mitochondrial respiration, however, hepatic mitochondria from aged mice had lower O-2 consumption, lower complex IV and higher complex I content. Mitochondrial H2O2 production was highest in OVX groups and exacerbated by age, while mitochondrial lipid peroxidation was highest in the aged mice and exacerbated by OVX. Regardless of age, OVX resulted in lower mitochondrial content of antioxidant glutathione peroxidase 1 (Gpx1). Isolated liver tissue from a sub-set of animals were acutely treated with conditioned ovarian media which increased Gpx1 mRNA expression compared to vehicle treated liver tissue.
   Conclusion: Ovarian secretory function is necessary for the maintenance of hepatic ROS buffering capacity in the mitochondria, while age significantly influences mitochondrial respiration. These data suggest that when age is coupled with loss of ovarian function there is an increased risk for developing hepatic mitochondrial dysfunction, which may influence the onset of metabolic disease. Thus, in females there is critical organ cross-talk occurring between hepatic tissue and the ovary that impacts hepatic mitochondrial function. (C) 2015 Elsevier Inc. All rights reserved.
C1 [Valencia, Ana P.; Spangenburg, Espen E.] Univ Maryland, Dept Kinesiol, College Pk, MD 20742 USA.
   [Schappal, Anna E.] Univ Maryland, Dept Nutr, College Pk, MD 20742 USA.
   [Morris, E. Matthew; Thyfault, John P.] Univ Missouri, Dept Nutr & Exercise Physiol Med, Div Gastroenterol & Hepatol, Columbia, MO 65201 USA.
   [Morris, E. Matthew; Thyfault, John P.] Harry S Truman Mem VA Hosp, Res Serv, Columbia, MO 65201 USA.
   [Lowe, Dawn A.] Univ Minnesota, Dept Phys Med & Rehabil, Program Phys Therapy, Minneapolis, MN 55455 USA.
   [Lowe, Dawn A.] Univ Minnesota, Dept Phys Med & Rehabil, Program Rehabil Sci, Minneapolis, MN 55455 USA.
C3 University System of Maryland; University of Maryland College Park;
   University System of Maryland; University of Maryland College Park;
   University of Missouri System; University of Missouri Columbia; US
   Department of Veterans Affairs; Veterans Health Administration (VHA);
   Harry S. Truman Memorial Veterans' Hospital; University of Minnesota
   System; University of Minnesota Twin Cities; University of Minnesota
   System; University of Minnesota Twin Cities
RP Spangenburg, EE (corresponding author), E Carolina Univ, Brody Sch Med, East Carolina Diabet & Obes Inst, Dept Physiol, 115 Heart Dr,ECHI,Mail Stop 743, Greenville, NC 27834 USA.
EM spangenburge14@ecu.edu
RI Valencia, Ana/HOH-4405-2023; Thyfault, John/JMB-3070-2023
OI Thyfault, John/0000-0001-7920-7466; Lowe, Dawn/0000-0002-5784-9289;
   Valencia, Ana/0000-0002-2833-6492; Morris, E.
   Matthew/0000-0001-7046-3623
FU Baltimore Diabetes Research Training Center [DRTC-P60DK079637]; National
   Institute on Aging [AG-000268];  [DK088940];  [AG031743]
FX This work was funded in part by the Baltimore Diabetes Research Training
   Center (DRTC-P60DK079637) (E. E Spangenburg); funded in part to JPT
   (DK088940); funded in part to DAL (AG031743); A. P. Valencia was funded
   by National Institute on Aging Grant (AG-000268).
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NR 50
TC 17
Z9 22
U1 2
U2 12
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0531-5565
EI 1873-6815
J9 EXP GERONTOL
JI Exp. Gerontol.
PD JAN
PY 2016
VL 73
BP 14
EP 22
DI 10.1016/j.exger.2015.11.011
PG 9
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA DA3CR
UT WOS:000367674000003
PM 26608809
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Lujan, LML
   McCarty, MF
   Ruiz, JCG
   Lopez, ST
   Iloki-Assanga, SB
AF Lujan, Lidianys Maria Lewis
   McCarty, Mark F.
   Ruiz, Juan Carlos Galvez
   Lopez, Sergio Trujillo
   Iloki-Assanga, Simon Bernard
TI Nutraceutical and dietary measures with potential for preventing/
   controlling non-alcoholic fatty liver disease and its complications
SO HUMAN NUTRITION & METABOLISM
LA English
DT Article
DE Non-alcoholic fatty liver disease; Nutraceuticals/foods; Sirt1; AMPK;
   Nrf2; Vegan diet
ID OXIDATIVE STRESS; TRANSCRIPTIONAL ACTIVITY; GLUCOSE-HOMEOSTASIS;
   INSULIN-RESISTANCE; THERAPEUTIC TARGET; HEPATIC STEATOSIS;
   LIPID-METABOLISM; HEME OXYGENASE-1; MESSENGER-RNA; FERULIC ACID
AB Non-alcoholic fatty liver disease (NAFLD), a frequent complication of metabolic syndrome and visceral obesity, is characterized by marked accumulation of lipids in hepatocytes, accompanied by oxidant stress. In a substantial minority of cases, this progresses to steatohepatitis, which in turn can lead to life-threatening hepatic fibrosis and/or hepatocarcinogenesis. This essay analyzes the molecular biology underlying fat accumulation and oxidant stress in NAFLD and identifies targets that can be addressed by nutraceutical or dietary measures. Nutraceuticals with potential for prevention or control of NAFLD as suggested on theoretical grounds, and borne out by experience in rodent studies and/or clinical trials include ferulic acid, melatonin, methyl nicotinamide, tetrahydro curcumin, nicotinamide riboside, carnosic acid, urolithin A, quercetin, high-dose biotin, citrulline, astaxanthin, long-chain omega-3 fatty acids, berberine, lipoic acid, silibinin, N-acetylcysteine, taurine, capsaicin, spermidine, spirulina, and carnitine. Some of these agents can also address the NLRP3 inflammasome activation and transforming growth factor-beta signaling that play a role in driving the transition to steatohepatitis and fibrosis. In addition, soy isoflavones, via estrogen receptor-beta agonism, have anti-fibrotic potential, and supplemental glycine may blunt the contribution of Kupffer cells to the progression of NAFLD. Methods: The research articles to carry out this work were focused based on many searches and reviews in the following databases: Google Scholar, MDPI, PubMed, ScienceDirect and using the following keywords and combined synonyms: ("nutraceuticals" or " dietary measures " or " Non-alcoholic fatty liver disease (NAFLD) " or "Nrf2 '' or "Vegan diet") AND ("NAFLD" or "vascular function" or "inflammation"). The keywords were also searched in the references of the original articles included in this study Whole-food plant-based diets of modest protein content, owing to their impact on hormones such as fibroblast growth factor 21 and adiponectin, as well as on the obesity and metabolic syndrome underlying NAFLD, may also be protective in this syndrome. There is considerable potential for complex medical foods or nutraceutical supplementation regimens of rational design to aid prevention and control of NAFLD.
C1 [Lujan, Lidianys Maria Lewis; Ruiz, Juan Carlos Galvez; Iloki-Assanga, Simon Bernard] Univ Sonora, Dept Chem Biol Sci, Hermosillo 83000, Sonora, Mexico.
   [McCarty, Mark F.] Catalyt Longev Fdn, 811 B Nahant Ct, San Diego, CA 92109 USA.
   [Lopez, Sergio Trujillo; Iloki-Assanga, Simon Bernard] Univ Sonora, Dept Med & Hlth Sci, Hermosillo 83000, Mexico.
C3 Universidad de Sonora; Universidad de Sonora
RP Iloki-Assanga, SB (corresponding author), Univ Sonora, Dept Chem Biol Sci, Hermosillo 83000, Sonora, Mexico.
EM lidianys1@yahoo.es; markfmccarty@gmail.com; Sergio.trujillo@unison.mx;
   simon.iloki@unison.mx
RI Lewis Luján, Lidianys María/ISA-4070-2023; ILOKI ASSANGA, SIMON
   BERNARD/GNP-3218-2022
OI Trujillo Lopez, Sergio/0000-0002-6183-117X; ILOKI ASSANGA, SIMON
   BERNARD/0000-0002-2058-5881
FX Mark F. McCarty is co-inventor and co-owner of a US patent on
   nu-traceutical uses of phycocyanobilin-containing oligopeptides derived
   from spirulina. The other authors have no conflicts of interest to
   declare.
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NR 250
TC 0
Z9 0
U1 4
U2 6
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2666-1497
J9 HUM NUTR METAB
JI Hum. Nutr. Metab.
PD SEP
PY 2024
VL 37
AR 200281
DI 10.1016/j.hnm.2024.200281
EA JUL 2024
PG 13
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA ZZ0K4
UT WOS:001278988000001
OA gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Mendizábal, Y
   Llorens, S
   Nava, E
AF Mendizabal, Yolanda
   Llorens, Silvia
   Nava, Eduardo
TI Vasoactive effects of prostaglandins from the perivascular fat of
   mesenteric resistance arteries in WKY and SHROB rats
SO LIFE SCIENCES
LA English
DT Article
DE Endothelial function; Prostaglandins; Cyclooxygenase-2; Perivascular
   adipose tissue; Obesity; Metabolic syndrome; Vasoactive adipokines;
   SHROB; Mesenteric resistance artery
ID ADIPOSE-TISSUE; PROSTACYCLIN PRODUCTION; INSULIN-RESISTANCE; RELEASE;
   ACETYLCHOLINE; STIMULATION; MECHANISMS; VESSELS; STRESS; AORTA
AB Aims: We have studied the vasoactive role of prostaglandins derived from perivascular adipose tissue (PVAT) and their effects on endothelial function in healthy rats and rats with metabolic syndrome (SHRUB).
   Main methods: Mesenteric resistance arteries (MRA) from SHRUB and control rats (WKY) were mounted on wire myographs: a) together with a sphere of naturally occurring perivascular adipose tissue (with-PVAT group), orb) dissecting all the adventitial tissue (without-PVAT group).
   Key findings: Endothelial function, tested by acetylcholine reactivity of SHRUB arteries with PVAT, was significantly lower than that of WKY. With-PVAT arteries, especially the SHRUB, showed lower responses than those without PVAT. NO synthase inhibition diminished the acetylcholine responses in every group except the with-PVAT SHROB group. Blockade of cyclooxygenase-2, PGI(2)-IP, TXA(2)-TP, or TXA(2) synthase increased to different extents the arterial responses in the SHRUB with-PVAT group. PVAT from both rat strains revealed cyclooxygenase-2 activity and immunoassay confirmed the release of PGE(2), PGI(2) and TXA(2).
   Significance: Our major finding is that PVAT is a source of vasoactive prostaglandins in WKY and SHRUB. We also report that the presence of visceral PVAT causes endothelial dysfunction of resistance arteries in the SHRUB. The vascular responses to prostaglandins partly underlie the endothelial dysfunction of SHRUB arteries. (C) 2013 Elsevier Inc. All rights reserved.
C1 Univ Castilla La Mancha, Sch Med, Dept Med Sci, Area Physiol, Albacete, Spain.
   Reg Ctr Biomed Res CRIB, Albacete, Spain.
C3 Universidad de Castilla-La Mancha
RP Nava, E (corresponding author), Univ Castilla La Mancha, La Mancha Sch, Fac Med, Area Physiol, Albacete 02006, Spain.
EM eduardo.nava@uclm.es
RI Llorens, silvia/L-3675-2014
OI nava, eduardo/0000-0003-3259-0511; Llorens, Silvia/0000-0002-2104-5414
FU Fondo de Investigaciones Sanitarias [PI080473]; Consejeria de Educacion
   y Ciencia de Castilla-La Mancha [PII1I09-0166-3114]; FISCAM [MOV
   2007-JI/10]
FX This work was supported by: the Fondo de Investigaciones Sanitarias
   (Ref.: PI080473), and the Consejeria de Educacion y Ciencia de
   Castilla-La Mancha (Ref.: PII1I09-0166-3114). Y.M. was supported by
   FISCAM (MOV 2007-JI/10). We are grateful to Dr. M. Feletou for
   constructive comments during doctoral dissertation of Y.M. and to M.A.
   de la Cruz for technical assistance.
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NR 32
TC 39
Z9 44
U1 0
U2 3
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0024-3205
EI 1879-0631
J9 LIFE SCI
JI Life Sci.
PD DEC 18
PY 2013
VL 93
IS 25-26
BP 1023
EP 1032
DI 10.1016/j.lfs.2013.10.021
PG 10
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA 280ES
UT WOS:000329012100009
PM 24200844
DA 2025-06-11
ER

PT J
AU Pfeuffer, M
   Auinger, A
   Bley, U
   Kraus-Stojanowic, I
   Laue, C
   Winkler, P
   Rüfer, CE
   Frank, J
   Boesch-Saadatmandi, C
   Rimbach, G
   Schrezenmeir, J
AF Pfeuffer, M.
   Auinger, A.
   Bley, U.
   Kraus-Stojanowic, I.
   Laue, C.
   Winkler, P.
   Ruefer, C. E.
   Frank, J.
   Boesch-Saadatmandi, C.
   Rimbach, G.
   Schrezenmeir, J.
TI Effect of quercetin on traits of the metabolic syndrome, endothelial
   function and inflammation in men with different APOE isoforms
SO NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
LA English
DT Article
DE Metabolic syndrome; Quercetin; Endothelial function; Cardiovascular
   disease
ID CORONARY-ARTERY-DISEASE; APOLIPOPROTEIN-E; FATTY-ACID; FLAVONOID
   QUERCETIN; HEALTHY-SUBJECTS; BLOOD-PRESSURE; DYSFUNCTION; POLYPHENOLS;
   CELLS; RISK
AB Background and aims: The polyphenol quercetin may prevent cardiovascular diseases due to its vasorelaxant and anti-oxidative properties. We investigated the effects of quercetin on risk factors of atherosclerosis, biomarkers of inflammation and oxidative stress, depending on the apolipoprotein E (APOE) genotype.
   Methods and results: In a double-blind crossover study 49 healthy male subjects with APOE genotype 3/3 (n = 19), 3/4 (n = 22) and 4/4 (n = 8) consumed 150 mg/d quercetin or placebo for 8 weeks each, intermitted by a three-week washout phase. After each intervention, endothelial function, anthropometry, metabolic and inflammatory parameters were measured in the fasting and postprandial state following a standardized lipid-rich meal. Endothelial function was not changed. In all subjects combined, quercetin significantly decreased waist circumference (P = 0.004) and postprandial systolic blood pressure (P = 0.044). Postprandial triacylglycerol concentrations were significantly decreased and HDL-cholesterol concentrations increased after quercetin as compared to placebo consumption (P = 0.025). Quercetin also moderately increased levels of TNF alpha (P = 0.024). There was a significant gene-diet interaction for waist circumference and for body mass index (BMI).
   Conclusions: Quercetin supplementation improved some risk factors of cardiovascular disease, yet exerted slightly pro-inflammatory effects. Genotype-dependent effects were seen only on waist circumference and BMI. Copyright (C) 2011 Elsevier B.V. All rights reserved.
C1 [Pfeuffer, M.; Auinger, A.; Bley, U.; Kraus-Stojanowic, I.; Schrezenmeir, J.] Max Rubner Inst, Fed Res Inst Nutr & Food, Dept Physiol & Biochem Nutr, D-24103 Kiel, Germany.
   [Pfeuffer, M.; Auinger, A.; Bley, U.; Kraus-Stojanowic, I.; Ruefer, C. E.; Schrezenmeir, J.] Max Rubner Inst, Fed Res Inst Nutr & Food, Dept Physiol & Biochem Nutr, D-76131 Karlsruhe, Germany.
   [Frank, J.; Boesch-Saadatmandi, C.; Rimbach, G.] Inst Human Nutr & Food Sci, D-24098 Kiel, Germany.
   [Laue, C.; Winkler, P.] Tecura GmbH, Clin Res Ctr, Kiel, Germany.
RP Pfeuffer, M (corresponding author), Max Rubner Inst, Fed Res Inst Nutr & Food, Dept Physiol & Biochem Nutr, Haid & Neu Str 9, D-76131 Karlsruhe, Germany.
EM maria.pfeuffer@mri.bund.de; annegret.auinger@mri.bund.de;
   ulla.bley@gmx.de; Ina.Kraus-Stojanowic@mri.bund.de; c.laue@tecura.com;
   winkler-petra@gmx.de; corinna.ruefer@mri.bund.de;
   jan.frank@nutrition-research.de; cboeschs@gmail.com;
   rimbach@foodsci.uni-kiel.de; Juergen.Schrezenmeir@gmx.de
RI Rimbach, Gerald/A-7178-2011; Bosch, Christine/AGL-4328-2022; Frank,
   Jan/A-1763-2009
OI Rimbach, Gerald/0000-0001-7888-4684; Bosch,
   Christine/0000-0001-6705-5709; Frank, Jan/0000-0002-7548-5829
FU Federal Ministry of Education and Research within the project
   "Functional Foods for Vascular Health - from Nutraceuticals to
   Personalised Diets" [BMBF 0313856A]
FX This work was supported by a grant of Federal Ministry of Education and
   Research (BMBF 0313856A) within the project "Functional Foods for
   Vascular Health - from Nutraceuticals to Personalised Diets".
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NR 31
TC 137
Z9 142
U1 1
U2 27
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0939-4753
J9 NUTR METAB CARDIOVAS
JI Nutr. Metab. Carbiovasc. Dis.
PD MAY
PY 2013
VL 23
IS 5
BP 403
EP 409
DI 10.1016/j.numecd.2011.08.010
PG 7
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism; Nutrition
   & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism;
   Nutrition & Dietetics
GA 149RA
UT WOS:000319337600006
PM 22118955
DA 2025-06-11
ER

PT J
AU Park, SK
   Kim, MG
   Ryoo, JH
   Shin, JY
AF Park, Sung Keun
   Kim, Min-Gi
   Ryoo, Jae-Hong
   Shin, Ju-Young
TI Association of Serum Ferritin and the Development of Metabolic Syndrome
   in Middle-Aged Korean Men A 5-year follow-up study
SO DIABETES CARE
LA English
DT Article
ID NUTRITION EXAMINATION SURVEY; CARDIOVASCULAR RISK-FACTORS; 3RD
   NATIONAL-HEALTH; BODY IRON STORES; INSULIN-RESISTANCE;
   DIABETES-MELLITUS; OXIDATIVE STRESS; FREE-RADICALS; WOMEN; ADULTS
AB OBJECTIVE-Elevated serum ferritin has been known to be associated with the prevalence of metabolic syndrome (MetS). However, there was no research to examine whether serum ferritin levels have been actually associated with the prospective development of MetS. Accordingly, we carried out a prospective study to evaluate the longitudinal effects of baseline serum ferritin levels on the development of MetS.
   RESEARCH DESIGN ANDMETHODS-A MetS-free cohort of 18,022 healthy Korean men, who had participated in a medical health checkup program in 2005, was followed until 2010. MetS was defined according to the joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention. Cox proportional hazards models were performed.
   RESULTS-During 45,919.3 person-years of follow-up, 2,127 incident cases of MetS developed between 2006 and 2010. After adjusting for multiple covariates, the hazard ratios (95% CI) for incident MetS comparing the second quintile to the fifth quintile of serum ferritin levels versus the first quintile were 1.19 (0.98-1.45), 1.17 (0.96-1.43), 1.36 (1.12-1.65), and 1.66 (1.38-2.01), respectively (P for trend <0.001). These associations were apparent in the clinically relevant subgroup analyses.
   CONCLUSIONS-Elevated serum ferritin levels were independently associated with future development of MetS during the 5-year follow-up period.
C1 [Park, Sung Keun] Sungkyunkwan Univ, Kangbuk Samsung Hosp, Sch Med, Total Healthcare Ctr, Seoul, South Korea.
   [Ryoo, Jae-Hong] Sungkyunkwan Univ, Kangbuk Samsung Hosp, Sch Med, Dept Occupat Med, Seoul, South Korea.
   [Ryoo, Jae-Hong] Kyung Hee Univ, Sch Med, Dept Prevent Med, Seoul, South Korea.
   [Kim, Min-Gi] Dongguk Univ, Gyeongju Hosp, Dept Occupat & Environm Med, Gyeongju, South Korea.
   [Shin, Ju-Young] Seoul Natl Univ, Coll Med, Dept Prevent Med, Seoul, South Korea.
C3 Sungkyunkwan University (SKKU); Samsung Medical Center; Sungkyunkwan
   University (SKKU); Samsung Medical Center; Kyung Hee University; Dongguk
   University; Seoul National University (SNU)
RP Ryoo, JH (corresponding author), Sungkyunkwan Univ, Kangbuk Samsung Hosp, Sch Med, Total Healthcare Ctr, Seoul, South Korea.
EM armani131@naver.com
OI Shin, Ju-Young/0000-0003-1010-7525; Ryoo, Jae-Hong/0000-0002-5232-1426;
   Park, Sung Keun/0000-0003-4703-9917
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NR 34
TC 73
Z9 78
U1 0
U2 8
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0149-5992
J9 DIABETES CARE
JI Diabetes Care
PD DEC
PY 2012
VL 35
IS 12
BP 2521
EP 2526
DI 10.2337/dc12-0543
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 041UF
UT WOS:000311426000035
PM 22933431
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Zelle, DM
   Corpeleijn, E
   van Ree, RM
   Stolk, RP
   van der Veer, E
   Gans, ROB
   van der Heide, JJH
   Navis, G
   Bakker, SJL
AF Zelle, D. M.
   Corpeleijn, E.
   van Ree, R. M.
   Stolk, R. P.
   van der Veer, E.
   Gans, R. O. B.
   van der Heide, J. J. Homan
   Navis, G.
   Bakker, S. J. L.
TI Markers of the Hepatic Component of the Metabolic Syndrome as Predictors
   of Mortality in Renal Transplant Recipients
SO AMERICAN JOURNAL OF TRANSPLANTATION
LA English
DT Article
DE Cardiovascular risk factors; fatty liver disease; mortality; renal
   transplant patients
ID GAMMA-GLUTAMYL-TRANSFERASE; FATTY LIVER-DISEASE; CARDIOVASCULAR-DISEASE;
   INSULIN-RESISTANCE; ALANINE AMINOTRANSFERASE; OXIDATIVE STRESS; RISK;
   ATHEROSCLEROSIS; TRANSPEPTIDASE; GLUTAMYLTRANSFERASE
AB Cardiovascular disease (CVD) is a leading cause of mortality in renal transplant recipients (RTRs). Metabolic syndrome (MS) is highly prevalent in RTRs. Nonalcoholic fatty liver disease (NAFLD) is considered the hepatic component of MS. We investigated associations of NAFLD markers with MS and mortality. RTRs were investigated between 2001 and 2003. NAFLD markers, alanine aminotransferase (ALT), gamma-glutamyl transferase (GGT) and alkaline phosphatase (AP) were measured. Bone and nonbone fractions of AP were also determined. Death was recorded until August 2007. Six hundred and two RTRs were studied (age 52 +/- 12 years, 55% men). At baseline 388 RTRs had MS. Prevalence of MS was positively associated with liver enzymes. During follow-up for 5.3[4.5-5.7] years, 95 recipients died (49 cardiovascular). In univariate Cox regression analyses, GGT (HR = 1.43[1.21-1.69], p < 0.001) and AP (HR = 1.34[1.11-1.63], p = 0.003) were associated with mortality, whereas ALT was not. Similar associations were found for cardiovascular mortality. Adjustment for potential confounders, including MS, diabetes and traditional risk factors did not materially change these associations. Results for nonbone AP mirrored that for total AP. ALT, GGT and AP are associated with MS. Of these three enzymes, GGT and AP are associated with mortality, independent of MS. These findings suggest that GGT and AP are independently related to mortality in RTRs.
C1 [Gans, R. O. B.; Bakker, S. J. L.] Univ Med Ctr Groningen, Dept Internal Med, Groningen, Netherlands.
   [Zelle, D. M.; van Ree, R. M.; van der Heide, J. J. Homan; Navis, G.] Univ Med Ctr Groningen, Dept Nephrol, Groningen, Netherlands.
   [Corpeleijn, E.; Stolk, R. P.] Univ Med Ctr Groningen, Dept Epidemiol, Groningen, Netherlands.
   [van der Veer, E.] Univ Med Ctr Groningen, Dept Lab Med, Groningen, Netherlands.
   [van der Heide, J. J. Homan] Univ Groningen, Renal Transplant Program, NL-9700 AB Groningen, Netherlands.
C3 University of Groningen; University of Groningen; University of
   Groningen; University of Groningen; University of Groningen
RP Bakker, SJL (corresponding author), Univ Med Ctr Groningen, Dept Internal Med, Groningen, Netherlands.
EM s.j.l.bakker@int.umcg.nl
RI Stolk, Ronald/B-2341-2013; Bakker, Stephan/J-4023-2015
OI Stolk, Ronald/0000-0002-0518-1205; Corpeleijn, Eva/0000-0002-2974-3305;
   Bakker, Stephan/0000-0003-3356-6791; Gans, Reinold/0000-0001-5481-2387;
   van der Veer, Eveline/0000-0002-4825-9981
FU PREDICCt [01C-104]; Netherlands Heart Foundation; Dutch Diabetes
   Research Foundation and Dutch Kidney Foundation
FX This research was performed within the framework of CTMM, the Center for
   Translational Molecular Medicine (http://www.ctmm.nl), project PREDICCt
   (grant 01C-104), and supported by the Netherlands Heart Foundation,
   Dutch Diabetes Research Foundation and Dutch Kidney Foundation.
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NR 37
TC 25
Z9 28
U1 0
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1600-6135
EI 1600-6143
J9 AM J TRANSPLANT
JI Am. J. Transplant.
PD JAN
PY 2010
VL 10
IS 1
BP 106
EP 114
DI 10.1111/j.1600-6143.2009.02876.x
PG 9
WC Surgery; Transplantation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery; Transplantation
GA 534FP
UT WOS:000272882000017
PM 19951280
OA hybrid
DA 2025-06-11
ER

PT J
AU Sakka, S
   Siahanidou, T
   Voyatzis, C
   Pervanidou, P
   Kaminioti, C
   Lazopoulou, N
   Kanaka-Gantenbein, C
   Chrousos, GP
   Papassotiriou, I
AF Sakka, Sophia
   Siahanidou, Tania
   Voyatzis, Chronis
   Pervanidou, Panagiota
   Kaminioti, Christina
   Lazopoulou, Natalia
   Kanaka-Gantenbein, Christina
   Chrousos, George P.
   Papassotiriou, Ioannis
TI Elevated circulating levels of lipoprotein-associated phospholipase
   A2 in obese children
SO CLINICAL CHEMISTRY AND LABORATORY MEDICINE
LA English
DT Article
DE biomarkers; BMI; cardiovascular risk; children; lipids;
   lipoprotein-associated phospholipase A(2) (Lp-PLA2); obesity
ID ACTIVATING-FACTOR ACETYLHYDROLASE; CORONARY-HEART-DISEASE; C-REACTIVE
   PROTEIN; MIDDLE-AGED MEN; METABOLIC SYNDROME; CARDIOVASCULAR-DISEASE;
   CARDIOMETABOLIC RISK; INSULIN-RESISTANCE; ATHEROSCLEROSIS; LP-PLA(2)
AB Background: Obesity and cardiovascular disease (CVD) often co-exist, but the pathophysiologic mechanisms that link the two are not fully understood. Lipoprotein-associated phospholipase A 2 (Lp-PLA2) is involved in the modification of lipids within atheromatous plaques. Recently, circulating Lp-PLA2 was found to be predictive of thromboembolic episodes in adults, independently of a variety of other potential risk factors, including markers of inflammation, renal function, and hemodynamic stress. However, the function of this lipase and its importance as a biomarker in childhood obesity is much less studied. The aim of the study was to study Lp-PLA2, a non-traditional risk factor of CVD, in obese children.
   Methods: Sixty-seven lean [39 boys and 28 girls, mean body mass index (BMI) z-score -0.2 +/- 0.8] and 66 obese (32 boys and 34 girls, mean BMI z-score 4.4 +/- 1.2) age-matched (p = 0.251) children, aged 6-12 years, were studied. BMI z-score was calculated based on the Greek BMI growth curves, and children were categorized as obese according to the Cole criteria. All children underwent physical examination and a fasting morning blood sample was obtained for glucose, insulin, lipid profile, and Lp-PLA2 assessment. Plasma concentrations of Lp-PLA2 were determined by a commercially available Lp-PLA2 enzyme-linked immunosorbent assay kit (PLAC Test), while other measurements were performed using standard methods.
   Results: Plasma Lp-PLA2 levels were significantly higher in obese children (322.5 +/- 77.8 ng/mL) compared with normal-weight ones (278.0 +/- 64.4 ng/mL, p < 0.001). Lp-PLA2 concentrations were significantly correlated with the BMI z-score (p = 0.004). Receiver operating characteristic analysis on Lp-PLA2 values resulted in significant areas under the curve (AUC) for distinguishing between obese and normal-weight groups of children (AUC, 0.726; p < 0.001).
   Conclusions: We found significantly higher Lp-PLA2 levels in obese children than lean controls. Interestingly, they all had levels > 200 ng/mL, which are considered to correlate with atherosclerosis and a high thromboembolic risk in adults. The positive correlation of Lp-PLA2 with BMI suggests that Lp-PLA2 might be the link between obesity and increased cardiovascular risk, which can be elevated even at a very young age. Measurement of Lp-PLA2 in plasma could therefore represent a further biomarker for assessing increased CVD risk in obese children and adolescents.
C1 [Voyatzis, Chronis; Kaminioti, Christina; Papassotiriou, Ioannis] Aghia Sophia Childrens Hosp, Dept Clin Biochem, Athens 11527, Greece.
   [Sakka, Sophia; Siahanidou, Tania; Pervanidou, Panagiota; Lazopoulou, Natalia; Kanaka-Gantenbein, Christina; Chrousos, George P.] Univ Athens, Sch Med, Dept Pediat 1, Div Endocrinol Metab & Diabet, GR-11527 Athens, Greece.
C3 The Aghia Sophia Children's Hospital; Athens Medical School; National &
   Kapodistrian University of Athens
RP Papassotiriou, I (corresponding author), Aghia Sophia Childrens Hosp, Dept Clin Biochem, Athens 11527, Greece.
EM biochem@paidon-agiasofia.gr
RI Kanaka-Gantenbein, Christina/AAP-3697-2020; Siahanidou,
   Tania/AAC-3850-2020; Chrousos, George/G-8702-2011; Sakka,
   Sophia/S-7125-2019; Pervanidou, Panagiota/ABI-6356-2020
OI Pervanidou, Panagiota/0000-0002-6593-6489; Sakka,
   Sophia/0000-0003-0826-1523
FU Athens University [ELKE 70/3/ 5924-7303]
FX Funding was received from Athens University to G.P. and I.P. (ELKE 70/3/
   5924-7303), while Lp-PLA2 reagents and the protocol for the method
   installation were provided by dia-Dexus (San Francisco, CA, USA).
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NR 35
TC 21
Z9 23
U1 0
U2 3
PU WALTER DE GRUYTER GMBH
PI BERLIN
PA GENTHINER STRASSE 13, D-10785 BERLIN, GERMANY
SN 1434-6621
EI 1437-4331
J9 CLIN CHEM LAB MED
JI Clin. Chem. Lab. Med.
PD JUN
PY 2015
VL 53
IS 7
BP 1119
EP 1125
DI 10.1515/cclm-2014-1081
PG 7
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA CJ3XR
UT WOS:000355418300028
PM 25581763
DA 2025-06-11
ER

PT J
AU Dimitriadis, DG
   Mamplekou, E
   Dimitriadis, PG
   Komessidou, V
   Papakonstantinou, A
   Dimitriadis, GD
   Papageorgiou, C
AF Dimitriadis, Dimitrios G.
   Mamplekou, Efterpi
   Dimitriadis, Panayiotis G.
   Komessidou, Vasso
   Papakonstantinou, Alexandros
   Dimitriadis, George D.
   Papageorgiou, Charalambos
TI The Association Between Obesity and Hostility: The Mediating Role of
   Plasma Lipids
SO JOURNAL OF PSYCHIATRIC PRACTICE
LA English
DT Article
DE dyslipidemia; glucose; hostility; obesity; psychopathology
ID QUALITY-OF-LIFE; COMMON MENTAL-DISORDERS; METABOLIC SYNDROME;
   PSYCHIATRIC COMORBIDITY; CARDIOVASCULAR-DISEASE; DEPRESSIVE SYMPTOMS;
   GENERAL-POPULATION; FASTING GLUCOSE; RISK-FACTORS; PREVALENCE
AB Objective: Recent research indicates an association between obesity and psychopathology status, the nature of which remains unclear. We evaluated the mediating role of biochemical disturbances in this association among a treatment-seeking sample of obese individuals.
   Method: The study enrolled 143 consecutive overweight and obese individuals (mean age 35 +/- 9 y) and 143 normal-weight controls (mean age 34 +/- 9 y), matched by age and sex. We measured psychopathology features using the Symptom Checklist 90-Revised (SCL-90-R), a standardized self-evaluation rating scale, and biochemical parameters (plasma cholesterol, triglyceride, and fasting glucose levels) of all participants. Nonlinear regression models were used to estimate the associations among obesity, psychopathology, and biochemical factors.
   Results: Obesity was associated positively and significantly (P < 0.05) with all of the SCL-90-R subscales, with the exception of anxiety and phobic anxiety, as well as with levels of plasma glucose, cholesterol (P < 0.01), and triglycerides (P < 0.001). Tests for mediation showed that obesity was significantly associated, for the mediators of plasma cholesterol [ parameter estimate = -0.033, P < 0.05] and triglycerides (parameter estimate = -0.059, P < 0.05), only with hostility (parameter estimate = -0.024, P < 0.05 and parameter estimate = -0.041, P < 0.05, respectively).
   Conclusions: Our data suggest that biological substrates that are critically related to obesity, such as dyslipidemia, may mediate, at least in part, the association between obesity and hostility.
C1 [Dimitriadis, Dimitrios G.] Psychiat Hosp Attiki, Haidari, Greece.
   [Mamplekou, Efterpi] Gen Mil Hosp Athens, Dept Mental Hlth, Athens, Greece.
   [Dimitriadis, Panayiotis G.] Natl Tech Univ Athens, Sch Civil Engn, Dept Water Resources & Environm Engn, Athens, Greece.
   [Komessidou, Vasso; Papakonstantinou, Alexandros] Evangelismos Gen Hosp, Dept Surg 1, Athens, Greece.
   [Dimitriadis, George D.] Univ Athens, Sch Med, Attikon Univ Hosp, Dept Internal Med 2, Haidari, Greece.
   [Dimitriadis, George D.] Univ Athens, Sch Med, Attikon Univ Hosp, Res Inst, Haidari, Greece.
   [Papageorgiou, Charalambos] Univ Athens, Sch Med, Aiginit Univ Hosp, Dept Psychiat 1, GR-11527 Athens, Greece.
C3 National Technical University of Athens; Evangelismos Hospital;
   University Hospital Attikon; National & Kapodistrian University of
   Athens; University Hospital Attikon; National & Kapodistrian University
   of Athens; National & Kapodistrian University of Athens; Athens Medical
   School
RP Dimitriadis, DG (corresponding author), 85 Konstantinoupoleos Str, GR-16232 Attiki, Greece.
EM dimitrisd76@yahoo.gr
OI Papageorgiou, Charalabos/0000-0001-7635-1956; Dimitriadis, Panayiotis
   G./0000-0003-4956-8820
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   [No title captured]
NR 80
TC 3
Z9 3
U1 2
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1527-4160
EI 1538-1145
J9 J PSYCHIATR PRACT
JI J. Psychiatr. Pract.
PD MAY
PY 2016
VL 22
IS 3
BP 166
EP 174
DI 10.1097/PRA.0000000000000147
PG 9
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychiatry
GA DM0CM
UT WOS:000376010200002
PM 27123796
DA 2025-06-11
ER

PT J
AU Bannert, U
   Siewert-Markus, U
   Klinger-König, J
   Grabe, HJ
   Stracke, S
   Dörr, M
   Völzke, H
   Markus, MRP
   Töpfer, P
   Ittermann, T
AF Bannert, Urs
   Siewert-Markus, Ulrike
   Klinger-Koenig, Johanna
   Grabe, Hans J.
   Stracke, Sylvia
   Doerr, Marcus
   Voelzke, Henry
   Markus, Marcello R. P.
   Toepfer, Philipp
   Ittermann, Till
TI Major depression recurrence is associated with differences in
   obesity-related traits in women, but not in men
SO EUROPEAN PSYCHIATRY
LA English
DT Article
DE cardiometabolic health; comorbidity; major depression; obesity; sex
   differences
ID SEX-DIFFERENCES; VISCERAL ADIPOSITY; ATYPICAL FEATURES; WEIGHT CHANGE;
   SYMPTOMS; DISORDERS; DISEASE; ANTIDEPRESSANT; DYSREGULATION;
   INFLAMMATION
AB Background Obesity-related cardiometabolic comorbidity is common in major depressive disorder (MDD). However, sex differences and MDD recurrence may modify the MDD-obesity-link. Methods Sex-specific associations of MDD recurrence (single [MDDS] or recurrent episodes [MDDR]) and obesity-related traits were analyzed in 4.100 adults (51.6% women) from a cross-sectional population-based cohort in Germany (SHIP-Trend-0). DSM-IV-based lifetime MDD diagnoses and MDD recurrence status were obtained through diagnostic interviews. Obesity-related outcomes included anthropometrics (weight, body mass index, waist- and hip-circumference, waist-to-hip ratio, waist-to-height ratio), bioelectrical impedance analysis of body fat mass and fat-free mass, and subcutaneous (SAT) and visceral adipose tissue (VAT) from abdominal magnetic resonance imaging. Sex-stratified linear regression models predicting obesity-related traits from MDD recurrence status were adjusted for age, education, and current depressive symptoms. Results 790 participants (19.3%) fulfilled lifetime MDD criteria (23.8% women vs. 14.5% men, p<0.001). In women, MDDS was inversely associated with anthropometric indicators of general and central obesity, while MDDR was positively associated with all obesity-related traits, except waist-to-hip ratio and fat-free mass. In women, MDDR versus MDDS was associated with higher levels of obesity across all outcomes except fat-free mass. In men, MDD was positively associated with SAT regardless of MDD recurrence. Additionally, lifetime MDD was positively associated with VAT in men. Results remained significant in sensitivity analyses after exclusion of participants with current use of antidepressants. Conclusions The MDD-obesity association is modified by MDD recurrence and sex independent of current depressive symptoms. Accounting for sex and MDD recurrence may identify individuals with MDD at increased cardiometabolic risk.
C1 [Bannert, Urs] Univ Med Greifswald, Greifswald, Germany.
   [Siewert-Markus, Ulrike; Klinger-Koenig, Johanna; Grabe, Hans J.] Univ Med Greifswald, Dept Psychiat & Psychotherapy, Greifswald, Germany.
   [Grabe, Hans J.] German Ctr Neurodegenerat Dis DZNE, Site, Greifswald, Germany.
   [Stracke, Sylvia; Toepfer, Philipp] Univ Med Greifswald, Dept Internal Med A, Greifswald, Germany.
   [Doerr, Marcus; Markus, Marcello R. P.] Univ Med Greifswald, Dept Internal Med B, Greifswald, Germany.
   [Doerr, Marcus; Markus, Marcello R. P.; Ittermann, Till] German Ctr Cardiovasc Res DZHK, Partner Site Greifswald, Greifswald, Germany.
   [Voelzke, Henry; Ittermann, Till] Univ Med Greifswald, Inst Community Med, Dept Study Hlth Pomerania Clin Epidemiol Res, Greifswald, Germany.
   [Markus, Marcello R. P.] German Ctr Diabet Res DZD, Partner Site Greifswald, Greifswald, Germany.
C3 Universitat Greifswald; Greifswald Medical School; Universitat
   Greifswald; Greifswald Medical School; Helmholtz Association; German
   Center for Neurodegenerative Diseases (DZNE); Universitat Greifswald;
   Greifswald Medical School; Universitat Greifswald; Greifswald Medical
   School; German Centre for Cardiovascular Research; Universitat
   Greifswald; Greifswald Medical School; German Center for Diabetes
   Research (DZD)
RP Töpfer, P (corresponding author), Univ Med Greifswald, Dept Internal Med A, Greifswald, Germany.
EM philipp.toepfer@med.uni-greifswald.de
RI Stracke, Sylvia/ABB-8871-2020
OI Grabe, Hans J/0000-0003-3684-4208; Topfer, Philipp/0000-0002-0041-6538;
   Stracke, Sylvia/0000-0001-6200-4339; Siewert-Markus,
   Ulrike/0000-0002-5091-3380
FU Federal Ministry of Education and Research [01ZZ9603, 01ZZ0103,
   01ZZ0403]; Ministry of Cultural Affairs as well as the Social Ministry
   of the Federal State of Mecklenburg-West Pomerania; Siemens
   Healthineers, Erlangen, Germany; Federal State of Mecklenburg-West
   Pomerania
FX SHIP is part of the Community Medicine Research net of the University of
   Greifswald, Germany, which is funded by the Federal Ministry of
   Education and Research (grant Nos. 01ZZ9603, 01ZZ0103, and 01ZZ0403),the
   Ministry of Cultural Affairs as well as the Social Ministry of the
   Federal State of Mecklenburg-West Pomerania. MRI scans in SHIP and
   SHIP-TREND have been supported by a joint grant from Siemens
   Healthineers, Erlangen, Germany and the Federal State of
   Mecklenburg-West Pomerania.
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   ,, 2017, New England Journal of Medicine, V377, P13
NR 55
TC 2
Z9 2
U1 2
U2 3
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0924-9338
EI 1778-3585
J9 EUR PSYCHIAT
JI Eur. Psychiat.
PD SEP 20
PY 2024
VL 67
IS 1
AR e55
DI 10.1192/j.eurpsy.2024.1764
PG 8
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA G5G1S
UT WOS:001316910500001
PM 39301585
OA gold
DA 2025-06-11
ER

PT J
AU Vinereanu, D
   Fraser, AG
   Robinson, M
   Lee, A
   Tweddel, A
AF Vinereanu, D
   Fraser, AG
   Robinson, M
   Lee, A
   Tweddel, A
TI Adenosine provokes diastolic dysfunction in microvascular angina
SO POSTGRADUATE MEDICAL JOURNAL
LA English
DT Article
ID DOBUTAMINE STRESS ECHOCARDIOGRAPHY; NORMAL CORONARY-ARTERIES;
   SYNDROME-X; CHEST PAIN; VELOCITY
AB Adenosine stress echocardiography was performed in nine patients (58 ( 3) years, eight women) with documented microvascular angina. Global ventricular function was assessed by Tc-99m blood pool imaging and Doppler, whereas longitudinal ventricular function was assessed by simultaneous tissue Doppler echocardiography of the lateral mitral annulus. Adenosine was infused incrementally to onset of chest pain in all patients. There was no significant change in global or longitudinal systolic function. Adenosine induced global diastolic dysfunction, demonstrated by blood pool imaging and by Doppler of the transmitral flow. All patients had long axis diastolic dysfunction at peak adenosine, revealed by a ratio of early to late diastolic velocity of lateral mitral annulus <1, which was absent of rest. Adenosine, as a stress agent, provokes regional and global diastolic dysfunction in microvascular angina, which may be a consequence of subendocardial ischaemia, Long axis diastolic dysfunction can be easily revealed by tissue Doppler of the lateral annular motion.
C1 Univ Wales Hosp, Dept Cardiol, Cardiff CF4 4XW, S Glam, Wales.
C3 Cardiff University
RP Tweddel, A (corresponding author), Univ Wales Hosp, Dept Cardiol, Heath Pk, Cardiff CF4 4XW, S Glam, Wales.
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NR 14
TC 19
Z9 21
U1 0
U2 0
PU BRITISH MED JOURNAL PUBL GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 0032-5473
J9 POSTGRAD MED J
JI Postgrad. Med. J.
PD JAN
PY 2002
VL 78
IS 915
BP 40
EP 42
DI 10.1136/pmj.78.915.40
PG 3
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 508GW
UT WOS:000173081200009
PM 11796872
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Cai, J
   Yang, ZC
   Zhao, S
   Ke, X
AF Cai, Jing
   Yang, Zhichao
   Zhao, Sen
   Ke, Xing
TI Associations of dichlorophenol with metabolic syndrome based on
   multivariate-adjusted logistic regression: a US nationwide
   population-based study 2003-2016
SO ENVIRONMENTAL HEALTH
LA English
DT Article
DE Para-dichlorobenzene; 2,5-dichlorophenol; Urine; Metabolic syndrome;
   Population-based study
ID URINARY CONCENTRATIONS; UNITED-STATES; 2,4-DICHLOROPHENOL; HEALTH;
   ADULTS; 2,5-DICHLOROPHENOL; CHOLESTEROL; PESTICIDES; EXPOSURE; OBESITY
AB Background Para-dichlorobenzene (p-DCB) exposure associated with oxidative stress has indeed raised public concerns. However, whether p-DCB is linked with metabolic syndrome (MetS) remains unclear. We hypothesized that higher exposure to p-DCB would be linked with a higher risk of MetS in the U.S population. This study aimed to examine the associations of exposure to p-DCB with MetS prevalence.Methods We included 10,428 participants (5,084 men and 5,344 women), aged >= 20 years, from the National Health and Nutrition Examination Survey (2003-2016). The cases of MetS were diagnosed by NCEP/ATPIII. Logistic regression models were conducted to calculate the odds ratios (ORs) and 95% confidence intervals (CIs) of MetS prevalence. Moreover, the mix associations of p-DCB metabolites were assessed using quantile sum (WQS) regression and quantile g-computation (qgcomp) methods.Results We documented 2,861 (27.1%) MetS cases. After adjustment for the potential risk factors, the ORs (95% CI) of MetS prevalence across the quartile of urinary 2,5-dichlorophenol (2,5-DCP) were 1.09 (0.93-1.28), 1.22 (1.00-1.49), and 1.34 (1.04-1.73). Moreover, 2,5 DCP is significantly associated with a higher prevalence of abdominal obesity [ORQ4vsQ1 (95% CI): 1.23 (1.03-1.48)]. The WQS and qgcomp index also showed significant associations between p-DCB metabolites and MetS. Moreover, we further examined that 2,5 DCP was correlated with higher systolic blood pressure (r = 0.022, P = 0.027), waist circumference (r = 0.099, P < 0.001), and glycohemoglobin (r = 0.027, P = 0.008) and a lower high density cholesterol (r = -0.059, P < 0.001). In addition, the significant positive associations between 2,5 DCP and MetS were robust in the subgroup and sensitivity analyses.Conclusion These findings indicated that increased urinary p-DCB concentration, especially 2,5 DCP, had a higher MetS prevalence. These results should be interpreted cautiously and further research is warranted to validate our findings.
C1 [Cai, Jing; Yang, Zhichao; Zhao, Sen; Ke, Xing] Zhejiang Police Coll, Key Lab Drug Prevent & Control Technol Zhejiang Pr, Hangzhou 310053, Peoples R China.
C3 Zhejiang Police College
RP Ke, X (corresponding author), Zhejiang Police Coll, Key Lab Drug Prevent & Control Technol Zhejiang Pr, Hangzhou 310053, Peoples R China.
EM kexing@zjjcxy.cn
FU The Science and Technology Department of Zhejiang Province
FX No Statement Available
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NR 51
TC 5
Z9 5
U1 0
U2 4
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1476-069X
J9 ENVIRON HEALTH-GLOB
JI Environ. Health
PD DEC 15
PY 2023
VL 22
IS 1
AR 88
DI 10.1186/s12940-023-01037-z
PG 12
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA CS0H7
UT WOS:001127108500001
PM 38102676
OA Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Zang, ST
   Luan, J
   Li, L
   Wu, QJ
   Chang, Q
   Dai, HX
   Zhao, YH
AF Zang, Si-Tian
   Luan, Jie
   Li, Ling
   Wu, Qi-Jun
   Chang, Qing
   Dai, Hui-Xu
   Zhao, Yu-Hong
TI Air pollution and metabolic syndrome risk: Evidence from nine
   observational studies
SO ENVIRONMENTAL RESEARCH
LA English
DT Article
DE Air pollution; Metabolic syndrome; Observational study; Meta-analysis;
   Epidemiology
ID LONG-TERM EXPOSURE; TYPE-2 DIABETES-MELLITUS; PARTICULATE MATTER; GLOBAL
   ASSOCIATION; OXIDATIVE STRESS; BLOOD-PRESSURE; AMBIENT; HEALTH;
   INFLAMMATION; METAANALYSIS
AB Background and aims: Globally, the number of metabolic syndrome (MetS) cases has increased substantially over time. However, the association between air pollution (AP) and MetS risk has been contradictory in observational studies. This is the first reported meta-analysis quantitatively exploring the aforementioned association. Methods: We searched PubMed, Embase, and Web of Science database entries up to September 14, 2020, and searches were updated up to December 6, 2020 to identify eligible articles on the AP-MetS risk association. No language restriction was imposed. Random-effects models were applied to estimate summary and subgroup effect sizes with 95% confidence intervals (CIs). PROSPERO registration number: CRD42020210431. Results: Eight articles (nine studies) were eligible for the meta-analysis. Increased MetS prevalence was not found to be associated with particulate matter less than 1 mu m (PM1), 2.5 mu m (PM2.5), and 10 mu m (PM10) in diameter or nitrogen dioxide (NO2), and the summary effect sizes were 1.33 (95% CI: 0.95-1.85), 1.34 (95% CI: 0.96-1.89), 1.18 (95% CI: 0.98-1.19), and 1.28 (95% CI: 0.89-1.82), respectively, based on cross-sectional studies. The summary results indicated no association between each 10 mu g/m3 increase in PM2.5 and MetS incidence (effect size 2.78 [95% CI: 0.70-11.02]), based on cohort studies. Subgroup analysis demonstrated that MetS incidence in older men increased dramatically by 992% with each 10 mu g/m3 increase in PM2.5. Conclusions: The evidence presented here suggests that although exposure to PM1, PM2.5, PM10, or NO2 was not found to have a significant association with the occurrence of MetS, the statistical significance of the relationship between exposure to PM1, PM2.5, or PM10 and MetS prevalence was approximately borderline. More studies on AP-MetS risk association in low-/middle-income countries, as well as on the association between other air pollutants and MetS risk, are warranted. A sufficient number of high-quality studies is required to perform a meaningful meta-analysis of the relationship between air pollutants and MetS.
C1 [Zang, Si-Tian; Luan, Jie; Wu, Qi-Jun; Chang, Qing; Dai, Hui-Xu; Zhao, Yu-Hong] China Med Univ, Shengjing Hosp, Dept Clin Epidemiol, 36 Sanhao St, Shenyang 110004, Liaoning, Peoples R China.
   [Zang, Si-Tian; Luan, Jie; Wu, Qi-Jun; Chang, Qing; Dai, Hui-Xu] China Med Univ, Shengjing Hosp, Clin Res Ctr, 39 Huaxiang Rd, Shenyang 110022, Liaoning, Peoples R China.
   [Li, Ling] Univ Macau, Ctr Precis Med Res & Training, Ave Univ, Taipa 999078, Macao, Peoples R China.
C3 China Medical University; China Medical University; University of Macau
RP Zhao, YH (corresponding author), China Med Univ, Shengjing Hosp, Dept Clin Epidemiol, 36 Sanhao St, Shenyang 110004, Liaoning, Peoples R China.
EM stzhang@cmu.edu.cn; jluan@cmu.edu.cn; yc07610@connect.um.edu.mo;
   wuqj@sj-hospital.org; changq@sj-hospital.org; daihx@sj-hospital.org;
   zhaoyuhong@sj-hospital.org
RI li, lingling/HTR-2760-2023; zang, ST/AGH-1829-2022
OI Wu, Qi-Jun/0000-0001-9421-5114
FU National Key R&D Program of China [2017YFC0907405]; LiaoNing
   Revitalization Talents Program [XLYC1802095]; Key R&D Program of
   Liaoning Province [2019JH8/10300005]; Science and Technology Project of
   Liaoning Province [2019JH6/10400002]
FX This work was supported by the National Key R&D Program of China [grant
   number 2017YFC0907405]; the LiaoNing Revitalization Talents Program
   [grant number XLYC1802095]; the Key R&D Program of Liaoning Province
   [grant number 2019JH8/10300005]; and the Science and Technology Project
   of Liaoning Province [grant number 2019JH6/10400002].
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NR 50
TC 25
Z9 25
U1 1
U2 25
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0013-9351
EI 1096-0953
J9 ENVIRON RES
JI Environ. Res.
PD NOV
PY 2021
VL 202
AR 111546
DI 10.1016/j.envres.2021.111546
EA JUL 2021
PG 13
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA WD0OT
UT WOS:000704647900006
PM 34265350
DA 2025-06-11
ER

PT J
AU Banu, S
   Jabir, NR
   Manjunath, CN
   Shakil, S
   Kamal, MA
AF Banu, Shaheena
   Jabir, Nasimudeen R.
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   Shakil, Shazi
   Kamal, Mohammad A.
TI C-Peptide and its Correlation to Parameters of Insulin Resistance in the
   Metabolic Syndrome
SO CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
LA English
DT Article
DE Type 2 Diabetes Mellitus; Metabolic syndrome; C-peptide; Insulin
   resistance
AB The progress of metabolic syndrome (MetS) continues with the onset of type-2 diabetes mellitus (Type-2 DM) along with linkage to other disorders such as neurodegenerative, especially Alzheimer's disease (AD), via oxidative stress and low grade systemic inflammatory process. Type-2 DM and AD are health disorders of priority research. The treatment for an individual suffering with Type-2 DM and/or AD requires monitoring by clinicians. The aim of this study was to investigate the role of C-peptide and its correlation to insulin resistance, body mass index (BMI), beta cell function, insulin sensitivity, lipid profile and hemoglobin A1c (HbA1c). The study was designed to include 96 Type-2 DM individuals from India. 58.3% males and 41.7% females were selected and fasting blood samples were collected for estimation of fasting C-peptide, fasting blood sugar (FBS), postprandial blood sugar (PPBS), HbA1c and lipid profile. Analysis was done on Hitachi912 and Elecsys 2010 using Roche reagents and standard controls. Anthropometries to calculate BMI and beta cell function, insulin sensitivity, and insulin resistance were obtained. The statistical tool ANOVA, followed by calculation of p-value and r-value were applied for investigating correlation of C-peptide levels to those of high density lipoprotein-C (HDL-C), low density lipoprotein-C (LDL-C), triglycerides (TGL), HbA1c, beta cell function, insulin sensitivity and insulin resistance. Highly significant positive correlations were observed in different quantiles of C-peptide levels to the studied parameters of MetS, BMI and % beta cell function. Lower HDL-C level was found to be significantly related to higher C-peptide levels. Similarly, TGL and C-peptide levels displayed a significant positive correlation. A significant negative correlation was observed between C-peptide quantiles and % sensitivity. Thus, insulin resistance showed a positive correlation until the fourth quantile. No significant correlation was observed between C-peptide and HbA1c levels. This study demonstrates that assessment of C-peptide levels is a useful tool to monitor the progress of MetS among patients suffering from Type-2 DM and AD, as these disorders are intertwined to each other by common metabolic pathways. Assessment of C-peptide levels, along with HDL-C levels, in patients can be used to monitor insulin resistance.
C1 [Banu, Shaheena; Manjunath, C. N.] Sri Jayadeva Inst Cardiovasc Sci & Res, Dept Biochem, Bangalore, Karnataka, India.
   [Jabir, Nasimudeen R.; Shakil, Shazi; Kamal, Mohammad A.] King Abdulaziz Univ, King Fahd Med Res Ctr, Jeddah 21589, Saudi Arabia.
C3 King Abdulaziz University
RP Kamal, MA (corresponding author), King Abdulaziz Univ, King Fahd Med Res Ctr, POB 80216, Jeddah 21589, Saudi Arabia.
EM ma.kamal@live.com
RI Nasimudeen, Jabir/H-9483-2012; Shakil, Shazi/K-4132-2015; Kamal,
   Mohammad Amjad/J-2918-2014
OI Nasimudeen, Jabir/0000-0001-8548-7986; Shakil,
   Shazi/0000-0003-4075-9153; Kamal, Mohammad Amjad/0000-0003-0088-0565
CR Ahmed I, 2006, MT SINAI J MED, V73, P759
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NR 40
TC 22
Z9 26
U1 1
U2 7
PU BENTHAM SCIENCE PUBL
PI BUSUM
PA PO BOX 294, BUSUM, 1400 AG, NETHERLANDS
SN 1871-5273
EI 1996-3181
J9 CNS NEUROL DISORD-DR
JI CNS Neurol. Disord.-Drug Targets
PD DEC
PY 2011
VL 10
IS 8
BP 921
EP 927
DI 10.2174/187152711799219271
PG 7
WC Neurosciences; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pharmacology & Pharmacy
GA V28OE
UT WOS:000208689300010
PM 22229322
DA 2025-06-11
ER

PT J
AU Siervo, M
   Jackson, SJ
   Bluck, LJC
AF Siervo, Mario
   Jackson, Sarah J.
   Bluck, Les J. C.
TI In-vivo nitric oxide synthesis is reduced in obese patients with
   metabolic syndrome: application of a novel stable isotopic method
SO JOURNAL OF HYPERTENSION
LA English
DT Article
DE arginine; biological modelling; endothelial function; mass spectrometry;
   metabolic syndrome; nitrate; nitric oxide; stable isotopes
ID CHROMATOGRAPHY MASS-SPECTROMETRY; L-ARGININE; INSULIN-RESISTANCE;
   OXIDATIVE STRESS; NO SYNTHESIS; DISEASE; NITRATE; HUMANS; URINARY;
   PATHOPHYSIOLOGY
AB Objectives Nitric oxide synthesis is declined in cardiovascular and metabolic diseases associated with endothelial dysfunction such as type 2 diabetes, hypertension or congestive heart failure. The objectives were to validate a novel stable isotopic method for the determination of in-vivo nitric oxide synthesis and to evaluate differences in nitric oxide synthesis in obese patients with and without metabolic syndrome (MetSyn).
   Methods The new method, called oral nitrate test (ONT), measured the decay in saliva or urine samples of an oral dose of labelled sodium nitrate. The ONT method was compared to a validated method (frequent sampling arginine test, FSAT method) in 10 healthy adult volunteers (BMI range=20.8-27.3 kg/m(2)). The accuracy of the saliva ONT method was then tested by measuring nitric oxide synthesis in seven healthy, normal weight individuals, seven obese patients without MetSyn and seven obese patients with MetSyn.
   Results The estimated rate of nitric oxide synthesis was 0.63+/-0.20 mu mol/h per kg from the data obtained from saliva, and 0.50+/-0.14 mu mol/h per kg from urine. The agreement of the saliva ONT method with the FSAT method (Delta=+0.02+/-0.24; P=0.79) was superior to the urine ONT method (Delta=-0.11+/-0.20; P=0.13). Obese patients with MetSyn had a significantly lower nitric oxide production rate (0.21+/-0.13 mu mol/h per kg; P=0.009) than healthy normal weight individuals (0.63+/-0.30 mu mol/h per kg), whereas nitric oxide production rate was intermediate in obese patients without MetSyn (0.49+/-0.22 mu mol/h per kg; P=0.33).
   Conclusion The advantages of the new saliva ONT method are its accuracy, sensitivity and lack of invasiveness, which could make it a reference method for the assessment of in-vivo rates of whole-body nitric oxide synthesis. J Hypertens 29: 1515-1527 (C) 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins.
C1 [Siervo, Mario; Jackson, Sarah J.; Bluck, Les J. C.] MRC Human Nutr Res, Elsie Widdowson Lab, Cambridge CB1 9NL, England.
C3 UK Research & Innovation (UKRI); Medical Research Council UK (MRC); MRC
   Human Nutrition Research
RP Bluck, LJC (corresponding author), MRC Human Nutr Res, Elsie Widdowson Lab, Fulbourn Rd, Cambridge CB1 9NL, England.
EM Les.Bluck@mrc-hnr.cam.ac.uk
RI Siervo, Mario/AAB-9302-2019
OI Siervo, Mario/0000-0001-5515-0944
FU Medical Research Council; MRC [MC_UP_A090_1005] Funding Source: UKRI
FX The authors would like to thank Louise McKenna, Emma Perssoon, Aurelie
   Tireford, Shelley Parker and Susan Bryant for their help. This work is
   also dedicated to the memory of Professor Andy Coward who participated
   in the conception of the model and development of the study design. This
   study was funded by the Medical Research Council.
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NR 52
TC 39
Z9 41
U1 0
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0263-6352
J9 J HYPERTENS
JI J. Hypertens.
PD AUG
PY 2011
VL 29
IS 8
BP 1515
EP 1527
DI 10.1097/HJH.0b013e3283487806
PG 13
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 791TL
UT WOS:000292688400009
PM 21720276
DA 2025-06-11
ER

PT J
AU Liang, ZH
   Zhang, Y
   Li, GY
AF Liang, Zhaohuang
   Zhang, Yao
   Li, Guoyue
TI Association between vitamin D levels and risk of periodontitis in
   patients with metabolic syndrome
SO JOURNAL OF DENTAL SCIENCES
LA English
DT Article
DE Vitamin D; Periodontitis; Metabolic syndrome
ID OXIDATIVE STRESS; D DEFICIENCY; PREVALENCE; DIAGNOSIS
AB Background/purpose: The relationship between Vitamin D (VD) and periodontitis in patients with metabolic syndrome (MetS) was unclear. This study was to investigate the relationship between VD and periodontitis in MetS patients. Materials and methods: This cross-sectional study collected the data of 2165 MetS patients from the National Health and Nutrition Examination Survey (NHANES). The weighted univariate and multivariable Logistic regression models were applied to identify covariates and evaluate the association between 25-hydroxy vitamin D (25(OH)D) [25(OH)D](2) + 25(OH)D-3 and periodontitis in patients. Odds ratio (OR) [95% confidence interval (CI)] was effect size. Subgroup analysis was performed in people with or without diabetes, dyslipidemia, hypertension, cardiovascular disease (CVD) and central obesity groups. Results: In the unadjusted model, compared with patients with 25(OH)D-2 + 25(OH)D-3 < 50 nmol/L, those with 25(OH)D-2 + 25(OH)D-3 >= 50 nmol/L might be associated with decreased risk of periodontitis in MetS patients (OR = 0.70, 95% CI: 0.57-0.85). After adjusting for confounders including age, gender, race, education, poverty income ratio (PIR), smoking, diabetes, VD intake and supplement and number of missing teeth, 25(OH)D-2 + 25(OH)D-3 >= 50 nmol/L was correlated with reduced risk of periodontitis in MetS patients (OR = 0.76, 95% CI: 0.60-0.97). Subgroup analysis revealed that in patients with CVD (OR = 0.60, 95% CI: 0.37-0.98), dyslipidemia (OR = 0.75, 95% CI: 0.57-0.97), and patients with central obesity (OR = 0.73, 95% CI: 0.57-0.95), decreased risk of periodontitis was identified in 25(OH)D-2 + 25(OH)D-3 >= 50 nmol/L. Conclusion: VD was associated with the risk of periodontitis in patients with MetS, which suggest the importance of VD supplement in patients with MetS and provide a reference for the management of periodontitis in patients with MetS. (c) 2023 Association for Dental Sciences of the Republic of China. Publishing services by Elsevier B.V. This is an open access article under the CC BY -NC -ND license (http://creativecommons. org/licenses/by-nc-nd/4.0/).
C1 [Liang, Zhaohuang; Zhang, Yao; Li, Guoyue] Capital Med Univ, Beijing Stomatol Hosp, Dept Gen Dent & Integrated Emergency Dent Care, 4 Tiantan Xili, Beijing 100050, Peoples R China.
C3 Capital Medical University
RP Liang, ZH (corresponding author), Capital Med Univ, Beijing Stomatol Hosp, Dept Gen Dent & Integrated Emergency Dent Care, 4 Tiantan Xili, Beijing 100050, Peoples R China.
EM zhaohuangliangl@outlook.com
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NR 35
TC 0
Z9 0
U1 1
U2 4
PU ELSEVIER TAIWAN
PI TAIPEI
PA RM N-412, 4F, CHIA HSIN BUILDING 11, NO 96, ZHONG SHAN N ROAD SEC 2,
   TAIPEI, 10449, TAIWAN
SN 1991-7902
EI 2213-8862
J9 J DENT SCI
JI J. Dental Sci.
PD APR
PY 2024
VL 19
IS 2
BP 1012
EP 1020
DI 10.1016/j.jds.2023.06.026
EA APR 2024
PG 9
WC Dentistry, Oral Surgery & Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dentistry, Oral Surgery & Medicine
GA QV5W5
UT WOS:001223667900001
PM 38618072
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Almeida-de-Souza, J
   Santos, R
   Lopes, L
   Abreu, S
   Moreira, C
   Padrao, P
   Mota, J
   Moreira, P
AF Almeida-de-Souza, Juliana
   Santos, Rute
   Lopes, Luis
   Abreu, Sandra
   Moreira, Carla
   Padrao, Patricia
   Mota, Jorge
   Moreira, Pedro
TI Associations between fruit and vegetable variety and low-grade
   inflammation in Portuguese adolescents from LabMed Physical Activity
   Study
SO EUROPEAN JOURNAL OF NUTRITION
LA English
DT Article
DE C-reactive protein; Interleukin 6; Complement C3; Complement C4;
   Inflammatory score; Variety of diet
ID C-REACTIVE PROTEIN; CARDIOMETABOLIC RISK-FACTORS;
   CORONARY-HEART-DISEASE; HEALTHY-YOUNG MEN; BODY-MASS INDEX;
   MYOCARDIAL-INFARCTION; ABDOMINAL ADIPOSITY; BIOACTIVE COMPOUNDS;
   METABOLIC SYNDROME; OXIDATIVE STRESS
AB Purpose The dietary guidelines for the consumption of a variety of fruits and vegetables have been recognized as an important factor for achieving healthy eating patterns to reduce the risk of chronic disease throughout the lifes-pan. Our aim is to assess the association between fruit and vegetable variety and low-grade inflammation in adolescents.
   Methods This cross-sectional analysis was conducted with 412 adolescents (ages 14.4 +/- 1.7 years; 52% girls). The consumption of a variety of fruits and vegetables was assessed with a food-frequency questionnaire, considering the number of individual/category of fruit or vegetable intake at least once month, and categorized into tertiles. Blood samples were collected to determine C-reactive protein (CRP), interleukin-6 (IL-6), complement component 3 (C3), and 4 (C4). We created categories of lower or higher (inflammatory state) for each biomarker, considering sex-and age-adjusted median values. Then, we computed an overall inflammatory score, by adding all points awarded wherein one point was assigned if biomarker was higher or zero if lower, and created categories of 0-1 or 2-4 biomarkers above the median. The odds ratio (OR) and 95% interval confidence (95% CI) were calculated from binary logistic regression to estimate the magnitude of association between fruit and vegetable variety and inflammatory biomarkers.
   Results Adolescents with a greater variety of vegetable consumption (>= 13 categories/month) had lower odds of having a higher CRP (OR 0.31, 95% CI 0.15-0.64, p(trend) = 0.004) when compared to those with lower variety consumption (<= 6 categories/month), independent of vegetable quantity intake. However, a greater variety of fruit consumption (>= 12 categories/month) had higher odds of having a higher IL-6 (OR 4.41, 95% CI 1.67-11.71, p(trend) = 0.012), C3 (OR 3.30, 95% CI 1.23-8.86, p(trend) = 0.047), and inflammatory score (OR 4.90, 95% CI 1.62-14.86, p(trend) = 0.017), when compared to those with lower variety consumption (<= 9 categories/month), independent of fruit quantity intake, only for girls.
   Conclusions The consumption of a variety of vegetables is inversely associated with lower CRP. This finding supports the current dietary guidelines regarding the consumption of a variety of vegetables. The role of fruit variety in low-grade inflammation should be further studied.
C1 [Almeida-de-Souza, Juliana] Polytech Inst Braganca, Sch Hlth, Av D Afonso V, P-5300121 Braganca, Portugal.
   [Almeida-de-Souza, Juliana; Padrao, Patricia; Moreira, Pedro] Univ Porto, Fac Nutr & Food Sci, Porto, Portugal.
   [Santos, Rute; Lopes, Luis; Abreu, Sandra; Moreira, Carla; Mota, Jorge; Moreira, Pedro] Univ Porto, Fac Sport, Res Ctr Phys Act Hlth & Leisure, Porto, Portugal.
   [Santos, Rute] Univ Wollongong, Early Start Res Inst, Wollongong, NSW, Australia.
   [Santos, Rute] Univ Inst Maia, Maia, Portugal.
   [Padrao, Patricia; Moreira, Pedro] Univ Porto, Inst Publ Hlth, Porto, Portugal.
C3 Instituto Politecnico de Braganca; Universidade do Porto; Universidade
   do Porto; University of Wollongong; Universidade do Porto
RP Almeida-de-Souza, J (corresponding author), Polytech Inst Braganca, Sch Hlth, Av D Afonso V, P-5300121 Braganca, Portugal.; Almeida-de-Souza, J (corresponding author), Univ Porto, Fac Nutr & Food Sci, Porto, Portugal.
EM julianaalmeida@ipb.pt
RI Lopes, Luis/AAX-7957-2020; Moreira, Pedro/K-5456-2012; Santos,
   Rute/A-6401-2012; Almeida-de-Souza, Juliana/AAY-7652-2020; mota,
   jorge/B-2980-2013; Moreira, Carla/G-5176-2011; Abreu,
   Sandra/L-7547-2013; Padrao, Patricia/K-8230-2012; Lopes,
   Luis/M-3767-2013; Moreira, Pedro/U-3034-2019
OI Padrao, Patricia/0000-0001-6310-4956; Lopes, Luis/0000-0001-6680-0893;
   Moreira, Pedro/0000-0002-7035-7799
FU Research Centre in Physical Activity, Health and Leisure (University of
   Porto); Portuguese Foundation for Science and Technology
   [UID/DTP/00617/2013]; program for advanced training
   [SFRH/PROTEC/68092/2010]; Australian Research Council [DE150101921];
   Fundação para a Ciência e a Tecnologia [UID/DTP/00617/2013] Funding
   Source: FCT
FX The authors gratefully acknowledged the participation of all adolescents
   and their parents, teachers and schools of the LabMed and Physical
   Activity Study. They also acknowledge the cooperation of volunteer's
   subjects, the Department of Hygiene and Epidemiology from Medical School
   (University of Porto) for the conversion the food-frequency
   questionnaire data into nutrients, and the Research Centre in Physical
   Activity, Health and Leisure (University of Porto) for the sponsoring
   the LabMed and Physical Activity Study. The research Centre in Physical
   Activity, Health and Leisure (University of Porto) is supported by the
   Portuguese Foundation for Science and Technology (UID/DTP/00617/2013).
   Almeida-de-Souza J had been supported by program for advanced training
   (SFRH/PROTEC/68092/2010). Rute Santos has a Discovery Early Career
   Research Award from the Australian Research Council (DE150101921).
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NR 87
TC 20
Z9 21
U1 0
U2 12
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1436-6207
EI 1436-6215
J9 EUR J NUTR
JI Eur. J. Nutr.
PD SEP
PY 2018
VL 57
IS 6
BP 2055
EP 2068
DI 10.1007/s00394-017-1479-y
PG 14
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA GQ7KL
UT WOS:000441919500003
DA 2025-06-11
ER

PT J
AU Schultz, KAP
   Chen, L
   Chen, ZJ
   Zeltzer, LK
   Nicholson, HS
   Neglia, JP
AF Schultz, Kris Ann P.
   Chen, Lu
   Chen, Zhengjia
   Zeltzer, Lonnie K.
   Nicholson, H. Stacy
   Neglia, Joseph P.
TI Health and Risk Behaviors in Survivors of Childhood Acute Myeloid
   Leukemia: A Report From the Children's Oncology Group
SO PEDIATRIC BLOOD & CANCER
LA English
DT Article
DE leukemia; pediatric; smoking; survivor
ID ADULT SURVIVORS; MARROW-TRANSPLANTATION; METABOLIC SYNDROME; 5-YEAR
   SURVIVORS; CANCER; SMOKING; PARTNERSHIP; INDUCTION; CESSATION; COHORT
AB Background. Survivors of childhood acute myeloid leukemia (AML) face increased risks of chronic disease and secondary malignancies. Substance exposure may compound these risks. Procedures. Participants were diagnosed with AML at <21 years of age and survived >= 5 years following diagnosis. All underwent chemotherapy alone or followed by autologous BMT (chemo +/- autoBMT) or underwent allogeneic BMT (alloBMT) if an HLA-matched related donor was available. Survivors completed a health questionnaire and a Youth Risk Behavior Survey (YRBS). Results. Of eligible survivors, 117 were >= 18 years of age and completed a YRBS. Survivors were a mean age of 10 years at diagnosis and 24 years at interview. Of the substance exposures assessed by YRBS, tobacco, alcohol, and marijuana were most common. Twenty-two percent (22%) had smoked cigarettes in the last 30 days. One-quarter (25%) reported binge drinking in the last month. None of these exposures varied by treatment group. Less than 10% of survivors reported cocaine, heroin, or methamphetamine use. Men were more likely to report high substance exposure (P= 0.004). Sadness/suicidality score was associated with cancer-related anxiety (P=0.006) and multiple health conditions (P=0.006). Conclusions. This analysis reveals exposure to tobacco, alcohol, and marijuana in young adults with few differences based on treatment received. Survivors with cancer-related anxiety or multiple health conditions were more likely to report sadness/hopelessness. Pediatr Blood Cancer 2010;55:157-164. (C) 2010 Wiley-Liss, Inc.
C1 [Schultz, Kris Ann P.] Childrens Hosp & Clin Minnesota, Div Hematol Oncol, St Paul, MN 55102 USA.
   [Chen, Lu] Childrens Oncol Grp, Arcadia, CA USA.
   [Chen, Lu] Univ So Calif, Dept Prevent Med, Los Angeles, CA 90089 USA.
   [Chen, Zhengjia] Emory Univ, Dept Biostat, Atlanta, GA 30322 USA.
   [Zeltzer, Lonnie K.] Univ Calif Los Angeles, Dept Pediat Anesthesiol & Psychiat, Los Angeles, CA USA.
   [Nicholson, H. Stacy] OHSU, Dept Pediat Hematol Oncol, Portland, OR USA.
   [Neglia, Joseph P.] Univ Minnesota, Dept Pediat Hematol Oncol, Minneapolis, MN USA.
C3 Children's Hospitals & Clinics of Minnesota; Children's Oncology Group
   (COG); University of Southern California; Emory University; University
   of California System; University of California Los Angeles; Oregon
   Health & Science University; University of Minnesota System; University
   of Minnesota Twin Cities
RP Schultz, KAP (corresponding author), Childrens Hosp & Clin Minnesota, Div Hematol Oncol, 347 N Smith Ave, St Paul, MN 55102 USA.
EM krisann.schultz@childrensmn.org
OI Zeltzer, Lonnie/0000-0001-9306-9450; Neglia, Joseph/0000-0002-5525-0598
FU Children's Cancer Research Fund; Children's Oncology Group; National
   Cancer Institute, Children's Cancer Study Group [5U10 CA07306,
   5U10CA78960, U10 CA98413, U10 CA98543, U24 CA55727]
FX Grant sponsor: Children's Cancer Research Fund; Grant sponsor:
   Children's Oncology Group; Grant sponsor: National Cancer Institute,
   Children's Cancer Study Group; Grant numbers: 5U10 CA07306, 5U10CA78960,
   U10 CA98413, U10 CA98543; Grant sponsor: National Cancer Institute;
   Grant number: U24 CA55727.
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NR 31
TC 30
Z9 31
U1 0
U2 8
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1545-5009
EI 1545-5017
J9 PEDIATR BLOOD CANCER
JI Pediatr. Blood Cancer
PD JUL 15
PY 2010
VL 55
IS 1
BP 157
EP 164
DI 10.1002/pbc.22443
PG 8
WC Oncology; Hematology; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Hematology; Pediatrics
GA 601BJ
UT WOS:000278032700034
PM 20232426
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Yimam, M
   Jiao, P
   Hong, M
   Brownell, L
   Lee, YC
   Kim, HJ
   Nam, JB
   Kim, MR
   Jia, Q
AF Yimam, Mesfin
   Jiao, Ping
   Hong, Mei
   Brownell, Lidia
   Lee, Young-Chul
   Kim, Hyun-Jin
   Nam, Jeong-Bum
   Kim, Mi-Ran
   Jia, Qi
TI A Botanical Composition from Morus alba, Ilex
   paraguariensis, and Rosmarinus officinalis for Body Weight
   Management
SO JOURNAL OF MEDICINAL FOOD
LA English
DT Article
DE high fat diet; high fat & high fructose diet;
   obesity; metabolic syndrome
ID HIGH-FAT-DIET; STIMULATES GLUCOSE-UPTAKE; MULBERRY LEAF EXTRACT;
   CARNOSIC ACID; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   DIABETES-MELLITUS; AGENTS LORCASERIN; OXIDATIVE STRESS; LIPID-METABOLISM
AB Obesity is the largest and fastest growing public health catastrophe in the world affecting both adults and children with a prevalence impacting more than one-third of United States (US) adult population. Although the long-term solution lies in lifestyle changes in the form of dieting and exercise, intervention is required for those who are already obese. Unfortunately, treatment options remain quite limited due to associated side effects of conventional therapeutics. As a natural alternative, in this study we describe the beneficial effect of a standardized composition (UP603) comprised of extracts from Morus alba, Ilex paraguariensis, and Rosmarinus officinalis in improving metabolic disorders in high fat diet (HFD) and high fat & high fructose diet (HFFD) induced obese C57BL/6J mice. Mice treated with UP603 showed dose-correlated decrease in body weight gains compared to vehicle treated HFFD group. Following 7 weeks of treatment, the changes in body weight gains from baseline were found as 6.4%, 27.3%, 2.0%, 3.1%, 0.4%, and -2.9% for normal control diet, HFFD, Orlistat, 450, 650, and 850mg/kg UP603 treated animals, respectively. Reductions of 7.9-21.1% in total cholesterol, 25.4-44.6% in triglyceride, and 22.5-38.2% in low-density lipoprotein were observed for mice treated with 450-850mg/kg of UP603. In a dual energy X-ray absorptiometry scan, percentage body fat of 18.9%, 47.8%, 46.1%, and 40.4% were found for mice treated with normal control, HFD, Orlistat, and UP603, respectively. Reductions of 65.5% and 16.4% in insulin and leptin, respectively, and 2.1-fold increase in ghrelin level were also observed for the UP603 group. Statistically significant improvements in nonalcoholic steatohepatitis scores were also observed from liver histology for mice treated with UP603. Hence, UP603, a standardized botanical composition from M. alba, I. paraguariensis, and R. officinalis could potentially be considered as a natural alternative to maintain healthy body weight and to manage metabolic syndrome.
C1 [Yimam, Mesfin; Jiao, Ping; Hong, Mei; Brownell, Lidia; Jia, Qi] Unigen Inc, 3005 1st Ave, Seattle, WA 98121 USA.
   [Lee, Young-Chul; Kim, Hyun-Jin; Nam, Jeong-Bum; Kim, Mi-Ran] Unigen Inc, Chungnam, South Korea.
RP Yimam, M (corresponding author), Unigen Inc, 3005 1st Ave, Seattle, WA 98121 USA.
EM myimam@unigen.net
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NR 46
TC 10
Z9 10
U1 0
U2 15
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1096-620X
EI 1557-7600
J9 J MED FOOD
JI J. Med. Food
PD NOV
PY 2017
VL 20
IS 11
BP 1100
EP 1112
DI 10.1089/jmf.2017.0002
PG 13
WC Chemistry, Medicinal; Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Food Science & Technology; Nutrition &
   Dietetics
GA FM3MI
UT WOS:000414909700008
PM 28708468
DA 2025-06-11
ER

PT J
AU Firouzabadi, FD
   Shab-Bidar, S
   Jayedi, A
AF Firouzabadi, Fatemeh Dehghani
   Shab-Bidar, Sakineh
   Jayedi, Ahmad
TI The effects of omega-3 polyunsaturated fatty acids supplementation in
   pregnancy, lactation, and infancy: An umbrella review of meta-analyses
   of randomized trials
SO PHARMACOLOGICAL RESEARCH
LA English
DT Review
DE Infancy; Pregnancy; Lactation; Meta-analysis; Omega-3; Randomized trials
ID FISH-OIL; SYSTEMATIC REVIEWS; OMEGA-3-FATTY-ACID DHA;
   CARDIOVASCULAR-DISEASE; LOWERS INFLAMMATION; VISUAL DEVELOPMENT; RISK
   PREGNANCIES; LIPID EMULSIONS; PRETERM INFANTS; GROWTH MEASURES
AB We aimed to perform an umbrella review of systematic reviews and meta-analyses (SRMAs) of randomized clinical trials (RCT) of the effects of long-chain omega-3 fatty acid supplementation in pregnancy, lactation, and infancy. We searched PubMed, Scopus, and Web of Science to November 2020. Two independent investigators extracted the information, evaluated the methodological quality of SRMAs using A Measurement Tool to Assess Systematic Reviews-2 (AMSTAR2), and rated the certainty of evidence using the Grades of Recommendation, Assessment, Development and Evaluation (GRADE) approach. Either a fixed-effects or a random-effects model was used to recalculate the effect sizes and 95%CIs, depending on the number of trials. Overall, 28 SRMAs of RCTs, reporting 124 outcomes from 672 RCTs with 273,523 participants were considered eligible for the present umbrella review. Our results demonstrated evidence of moderate to high certainty that omega-3 supplementation reduced the risk of pre-eclampsia and low-birth weight and improved head circumference when used in pregnant women, and reduced severe retinopathy of prematurity and cholestasis when used in infancy. There were also favorable effects on preterm delivery, pre-natal and post-partum depression, glycemic control and inflammation markers in pregnant women, and sensitization to peanuts, positive skin prick tests, anthropometric measures, language development, visual acuity, and duration of ventilation in infants (GRADE = low). Our findings suggested that omega-3 supplementation during pregnancy can exert favorable effects against pre-eclampsia, low-birth weight, pre-term delivery, and post-partum depression, and can improve anthropometric measures, immune system, and visual activity in infants and cardiometabolic risk factors in pregnant mothers.
C1 [Firouzabadi, Fatemeh Dehghani; Shab-Bidar, Sakineh; Jayedi, Ahmad] Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Community Nutr, 44 Hojjat Dost Alley,Naderi St,Keshavarz Blvd, Tehran, Iran.
C3 Tehran University of Medical Sciences
RP Jayedi, A (corresponding author), Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Community Nutr, 44 Hojjat Dost Alley,Naderi St,Keshavarz Blvd, Tehran, Iran.
EM ahmadjayedi@yahoo.com
RI Jayedi, Ahmad/E-7237-2017
OI Dehghani Firouzabadi, Fatemeh/0000-0002-6684-4615; jayedi,
   ahmad/0000-0003-4231-3147
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NR 86
TC 28
Z9 29
U1 2
U2 19
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 1043-6618
EI 1096-1186
J9 PHARMACOL RES
JI Pharmacol. Res.
PY 2022
VL 177
AR 106100
DI 10.1016/j.phrs.2022.106100
EA FEB 2022
PG 9
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 2Q4WC
UT WOS:000820423600004
PM 35104631
DA 2025-06-11
ER

PT S
AU Derosa, G
   Maffioli, P
   Sahebkar, A
AF Derosa, Giuseppe
   Maffioli, Pamela
   Sahebkar, Amirhossein
BE Gupta, SC
   Prasad, S
   Aggarwal, BB
TI Piperine and Its Role in Chronic Diseases
SO ANTI-INFLAMMATORY NUTRACEUTICALS AND CHRONIC DISEASES
SE Advances in Experimental Medicine and Biology
LA English
DT Article; Book Chapter
DE Anti-depressant effects; Bioavailability enhancer; Insulin-resistance;
   Piperine
ID PLACEBO-CONTROLLED TRIAL; RANDOMIZED CONTROLLED-TRIAL; GASTRIC-CANCER
   CELLS; DOUBLE-BLIND; BLACK PEPPER; INSULIN-RESISTANCE; METABOLIC
   SYNDROME; HEPATIC STEATOSIS; OXIDATIVE STRESS; CURCUMIN
AB Alkaloids include a family of naturally occurring chemical compounds containing mostly basic nitrogen atoms. Piperine is an alkaloid present in black pepper (Piper nigrum), one of the most widely used spices, in long pepper (Piper longum), and other Piper species fruits belonging to the family of Piperaceae. Piperine is responsible for the black pepper distinct biting quality. Piperine has many pharmacological effects and several health benefits, especially against chronic diseases, such as reduction of insulin-resistance, anti-inflammatory effects, and improvement of hepatic steatosis. The aim of this chapter is to summarize the effects of piperine, alone or in combination with other drugs and phytochemicals, in chronic diseases.
C1 [Derosa, Giuseppe; Maffioli, Pamela] Univ Pavia, Dept Internal Med & Therapeut, Fdn IRCCS Policlin S Matteo, Ple C Golgi 2, I-27100 Pavia, Italy.
   [Derosa, Giuseppe; Maffioli, Pamela] Fdn IRCCS Policlin San Matteo, Ctr Prevent Surveillance Diag & Treatment Rare Di, Pavia, Italy.
   [Derosa, Giuseppe] Univ Pavia, Ctr Study Endocrine Metab Pathophysiol & Clin Res, Pavia, Italy.
   [Derosa, Giuseppe] Univ Pavia, Mol Med Lab, Pavia, Italy.
   [Maffioli, Pamela] Univ Pavia, PhD Sch Expt Med, Pavia, Italy.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Biotechnol Res Ctr, Mashhad, Iran.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Sch Med, Dept Med Biotechnol, POB 91779-48564, Mashhad, Iran.
C3 University of Pavia; IRCCS Fondazione San Matteo; IRCCS Fondazione San
   Matteo; University of Pavia; University of Pavia; University of Pavia;
   Mashhad University of Medical Sciences; Mashhad University of Medical
   Sciences
RP Derosa, G (corresponding author), Univ Pavia, Dept Internal Med & Therapeut, Fdn IRCCS Policlin S Matteo, Ple C Golgi 2, I-27100 Pavia, Italy.; Sahebkar, A (corresponding author), Mashhad Univ Med Sci, Sch Med, Dept Med Biotechnol, POB 91779-48564, Mashhad, Iran.
EM giuseppe.derosa@unipv.it; sahebkara@mums.ac.ir
RI Maffioli, Pamela/ABH-3390-2021; Sahebkar, Amirhossein/B-5124-2018;
   Maffioli, Pamela/E-9753-2012
OI Maffioli, Pamela/0000-0002-4285-6507
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   Xia Y, 2015, MOL CELL BIOCHEM, V398, P147, DOI 10.1007/s11010-014-2214-0
NR 42
TC 100
Z9 103
U1 5
U2 35
PU SPRINGER INTERNATIONAL PUBLISHING AG
PI CHAM
PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND
SN 0065-2598
EI 2214-8019
BN 978-3-319-41334-1; 978-3-319-41332-7
J9 ADV EXP MED BIOL
JI Adv.Exp.Med.Biol.
PY 2016
VL 928
BP 173
EP 184
DI 10.1007/978-3-319-41334-1_8
D2 10.1007/978-3-319-41334-1
PG 12
WC Chemistry, Medicinal; Medicine, Research & Experimental; Nutrition &
   Dietetics
WE Book Citation Index – Science (BKCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Research & Experimental Medicine; Nutrition &
   Dietetics
GA BH5GY
UT WOS:000400932100008
PM 27671817
DA 2025-06-11
ER

PT J
AU Slim, I
   Ach, K
   Chaïeb, L
AF Slim, Ines
   Ach, Koussay
   Chaieb, Larbi
TI Lipid Management in Ramadan
SO JOURNAL OF THE PAKISTAN MEDICAL ASSOCIATION
LA English
DT Article
DE Ramadan Fasting; Lipids; Management; Risk stratification; Comorbidities
ID DENSITY-LIPOPROTEIN CHOLESTEROL; DISEASE RISK REDUCTION; METABOLIC
   SYNDROME; MARKED INCREASE; ADIPONECTIN; PARAMETERS; HEALTHY; PROFILE;
   HDL
AB During Ramadan fast, Muslims must refrain from smoking, eating, drinking, having sexual activity, and consuming oral medications from sunrise to sunset. It has been previously shown that Ramadan fasting induces favourable changes on metabolic parameters, reduces oxidative stress and inflammation and promotes cardiovascular benefits. Although ill people are exempted from fasting, most patients with chronic diseases are keen on performing this Islamic-ritual. During recent years, Risk stratification and treatment adjustment during Ramadan are well known and structured in several guidelines for patients with diabetes mellitus. Data related to the effect of Ramadan fast on lipid profiles are less known and several controversies have been reported. Here, we focus on lipid profile and lipid management during Ramadan taking into account comorbidities and cardiovascular risk.
C1 [Slim, Ines] Farhat Hached Univ Hosp, Dept Endocrinol, Sousse, Tunisia.
   Univ Sousse, Ibn Jazzar Fac Med, Sousse, Tunisia.
C3 Universite de Sousse; Hopital Farhat Hached; Universite de Sousse
RP Slim, I (corresponding author), Farhat Hached Univ Hosp, Dept Endocrinol, Sousse, Tunisia.
EM ines.slim@yahoo.fr
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NR 38
TC 0
Z9 0
U1 0
U2 0
PU PAKISTAN MEDICAL ASSOC
PI KARACHI
PA PMA HOUSE, AGA KHAN III RD, KARACHI, 00000, PAKISTAN
SN 0030-9982
J9 J PAK MED ASSOC
JI J. Pak. Med. Assoc.
PD MAY
PY 2015
VL 65
IS 5
SU 1
BP S57
EP S61
PG 5
WC Medicine, General & Internal; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Research & Experimental Medicine
GA VI2UC
UT WOS:000467458400017
PM 26013790
DA 2025-06-11
ER

PT J
AU Traka, MH
   Mithen, RF
AF Traka, Maria H.
   Mithen, Richard F.
TI Plant Science and Human Nutrition: Challenges in Assessing
   Health-Promoting Properties of Phytochemicals
SO PLANT CELL
LA English
DT Review
ID CELL-LINE CACO-2; CRUCIFEROUS VEGETABLE CONSUMPTION; RICH BROCCOLI
   SPROUTS; DIET-INDUCED OBESITY; LUNG-CANCER RISK; BETA-CAROTENE;
   PROSTATE-CANCER; CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME;
   COLORECTAL-CANCER
AB The rise in noncommunicable chronic diseases associated with changing diet and lifestyles throughout the world is a major challenge for society. It is possible that certain dietary components within plants have roles both in reducing the incidence and progression of these diseases. We critically review the types of evidence used to support the health promoting activities of certain phytochemicals and plant-based foods and summarize the major contributions but also the limitations of epidemiological and observational studies and research with the use of cell and animal models. We stress the need for human intervention studies to provide high-quality evidence for health benefits of dietary components derived from plants.
C1 [Traka, Maria H.; Mithen, Richard F.] Inst Food Res, Norwich NR4 7UA, Norfolk, England.
C3 University of East Anglia; UK Research & Innovation (UKRI);
   Biotechnology and Biological Sciences Research Council (BBSRC); Quadram
   Institute
RP Mithen, RF (corresponding author), Inst Food Res, Norwich Res Pk, Norwich NR4 7UA, Norfolk, England.
EM richard.mithen@bbsrc.ac.uk
OI Mithen, Richard/0000-0001-7307-4324; Traka, Maria/0000-0002-6592-5691
FU BBSRC [BBS/E/F/00044431] Funding Source: UKRI
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NR 158
TC 83
Z9 94
U1 2
U2 64
PU AMER SOC PLANT BIOLOGISTS
PI ROCKVILLE
PA 15501 MONONA DRIVE, ROCKVILLE, MD 20855 USA
SN 1040-4651
EI 1532-298X
J9 PLANT CELL
JI Plant Cell
PD JUL
PY 2011
VL 23
IS 7
BP 2483
EP 2497
DI 10.1105/tpc.111.087916
PG 15
WC Biochemistry & Molecular Biology; Plant Sciences; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Plant Sciences; Cell Biology
GA 810XU
UT WOS:000294164300008
PM 21803940
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Lee, SH
   Park, SY
   Choi, CS
AF Lee, Shin-Hae
   Park, Shi-Young
   Choi, Cheol Soo
TI Insulin Resistance: From Mechanisms to Therapeutic Strategies
SO DIABETES & METABOLISM JOURNAL
LA English
DT Review
DE Diabetes mellitus; type 2; Insulin resistance; Metabolic syndrome;
   Therapeutics
ID PROTEIN-KINASE-C; INDUCED HEPATIC STEATOSIS; ELEMENT-BINDING PROTEIN;
   NECROSIS-FACTOR-ALPHA; GLUCOSE-INDUCED DESENSITIZATION; HEXOSAMINE
   SYNTHESIS PATHWAY; MUSCLE GLYCOGEN-SYNTHESIS; ACTIVATED RECEPTOR-GAMMA;
   FATTY-ACID OXIDATION; DIET-INDUCED OBESITY
AB Insulin resistance is the pivotal pathogenic component of many metabolic diseases, including type 2 diabetes mellitus, and is defined as a state of reduced responsiveness of insulin-targeting tissues to physiological levels of insulin. Although the underlying mechanism of insulin resistance is not fully understood, several credible theories have been proposed. In this review, we summarize the functions of insulin in glucose metabolism in typical metabolic tissues and describe the mechanisms proposed to underlie insulin resistance, that is, ectopic lipid accumulation in liver and skeletal muscle, endoplasmic reticulum stress, and inflammation. In addition, we suggest potential therapeutic strategies for addressing insulin resistance.
C1 [Lee, Shin-Hae; Park, Shi-Young; Choi, Cheol Soo] Gachon Univ, Korea Mouse Metab Phenotyping Ctr KMMPC, Lee Gil Ya Canc & Diabet Inst, Incheon, South Korea.
   [Choi, Cheol Soo] Gachon Univ, Dept Internal Med, Gil Med Ctr, Incheon, South Korea.
   [Choi, Cheol Soo] Gachon Univ, Div Mol Med, Coll Med, 21 Namdong Daero 774beon Gil, Incheon 21565, South Korea.
C3 Gachon University; Gachon University; Gachon University
RP Choi, CS (corresponding author), Gachon Univ, Div Mol Med, Coll Med, 21 Namdong Daero 774beon Gil, Incheon 21565, South Korea.
EM cschoi@gachon.ac.kr
FU Bio & Medical Technology Development Program of the National Research
   Foundation (NRF) - Korean government (MSIT) [2014M3A9D5A01073886];
   Gachon University [GCU-2018-0683]
FX This research was supported by the Bio & Medical Technology Development
   Program of the National Research Foundation (NRF) funded by the Korean
   government (MSIT) (No.2014M3A9D5A01073886) and by the Gachon University
   research fund of 2018 (GCU-2018-0683).
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NR 176
TC 465
Z9 496
U1 75
U2 520
PU KOREAN DIABETES ASSOC
PI SEOUL
PA 101-2104, LOTTE CASTLE PRES, 109 MAPO-DAERO, MAPO-GU, SEOUL, 04146,
   SOUTH KOREA
SN 2233-6079
EI 2233-6087
J9 DIABETES METAB J
JI Diabetes Metab. J.
PD JAN
PY 2022
VL 46
IS 1
BP 15
EP 37
DI 10.4093/dmj.2021.0280
PG 23
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 1Y2KU
UT WOS:000807972700003
PM 34965646
OA Green Published, gold
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Hsu, CN
   Tain, YL
AF Hsu, Chien-Ning
   Tain, You-Lin
TI The Good, the Bad, and the Ugly of Pregnancy Nutrients and Developmental
   Programming of Adult Disease
SO NUTRIENTS
LA English
DT Review
DE developmental origins of health and disease (DOHaD); gut microbiota;
   non-communicable disease; nutrient-sensing signal; nutrition; oxidative
   stress; pregnancy; reprogramming
ID RENIN-ANGIOTENSIN SYSTEM; LOW-PROTEIN-DIET; HIGH-FAT DIET; MATERNAL IRON
   RESTRICTION; SYSTOLIC BLOOD-PRESSURE; IN-UTERO EXPOSURE; SUPPLEMENTATION
   PREVENTS; METABOLIC SYNDROME; GENE-EXPRESSION; GUT MICROBIOTA
AB Maternal nutrition plays a decisive role in developmental programming of many non-communicable diseases (NCDs). A variety of nutritional insults during gestation can cause programming and contribute to the development of adult-onset diseases. Nutritional interventions during pregnancy may serve as reprogramming strategies to reverse programming processes and prevent NCDs. In this review, firstly we summarize epidemiological evidence for nutritional programming of human disease. It will also discuss evidence from animal models, for the common mechanisms underlying nutritional programming, and potential nutritional interventions used as reprogramming strategies.
C1 [Hsu, Chien-Ning] Kaohsiung Chang Gung Mem Hosp, Dept Pharm, Kaohsiung 833, Taiwan.
   [Hsu, Chien-Ning] Kaohsiung Med Univ, Sch Pharm, Kaohsiung 807, Taiwan.
   [Tain, You-Lin] Kaohsiung Chang Gung Mem Hosp, Dept Pediat, Kaohsiung 833, Taiwan.
   [Tain, You-Lin] Chang Gung Univ, Coll Med, Kaohsiung 833, Taiwan.
   [Tain, You-Lin] Kaohsiung Chang Gung Mem Hosp, Inst Translat Res Biomed, Kaohsiung 833, Taiwan.
C3 Chang Gung Memorial Hospital; Kaohsiung Medical University; Chang Gung
   Memorial Hospital; Chang Gung University; Chang Gung Memorial Hospital
RP Tain, YL (corresponding author), Kaohsiung Chang Gung Mem Hosp, Dept Pediat, Kaohsiung 833, Taiwan.; Tain, YL (corresponding author), Chang Gung Univ, Coll Med, Kaohsiung 833, Taiwan.; Tain, YL (corresponding author), Kaohsiung Chang Gung Mem Hosp, Inst Translat Res Biomed, Kaohsiung 833, Taiwan.
EM chien_ning_hsu@hotmail.com; tainyl@hotmail.com
RI Tain, You-Lin/H-2827-2019; Hsu, Chien-Ning/GLS-4014-2022
OI Hsu, Chien-Ning/0000-0001-7470-528X; Tain, You-Lin/0000-0002-7059-6407
FU Ministry of Science and Technology, Taiwan [MOST
   107-2314-B-182-045-MY3]; Chang Gung Memorial Hospital, Kaohsiung, Taiwan
   [CMRPG8H0831, CMRPG8J0251]
FX This work was supported by grant MOST 107-2314-B-182-045-MY3 from the
   Ministry of Science and Technology, Taiwan, and the grants CMRPG8H0831
   and CMRPG8J0251 from Chang Gung Memorial Hospital, Kaohsiung, Taiwan.
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NR 161
TC 87
Z9 91
U1 0
U2 9
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD APR
PY 2019
VL 11
IS 4
AR 894
DI 10.3390/nu11040894
PG 21
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA HX9SX
UT WOS:000467749800187
PM 31010060
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Rakotoarivelo, V
   Variya, B
   Ilangumaran, S
   Langlois, MF
   Ramanathan, S
AF Rakotoarivelo, Volatiana
   Variya, Bhavesh
   Ilangumaran, Subburaj
   Langlois, Marie-France
   Ramanathan, Sheela
TI Inflammation in human adipose tissues-Shades of gray, rather than white
   and brown
SO CYTOKINE & GROWTH FACTOR REVIEWS
LA English
DT Review
DE Human obesity; Cytokines; Inflammation; Adipose tissues
ID TUMOR-NECROSIS-FACTOR; INTERLEUKIN-1 RECEPTOR ANTAGONIST; DIET-INDUCED
   OBESITY; C-REACTIVE PROTEIN; ALTERNATIVELY ACTIVATED MACROPHAGES;
   ENDOPLASMIC-RETICULUM STRESS; HEPATIC INSULIN-RESISTANCE; INDUCED
   WEIGHT-LOSS; FACTOR-ALPHA; TNF-ALPHA
AB Chronic inflammation in adipose tissues has been associated with obesity and metabolic syndrome over the years. Various studies using animal models have contributed to our knowledge on the pro- and anti-inflammatory mediators that regulate obesity. Analyses of cytokine profiles in humans have not revealed a clear scenario. Likewise, treatments targeting inflammation to control obesity and insulin resistance has not yielded promising results. In this review we summarize the data available in human obesity and discuss the possible reasons that could explain the difficulties in treating obesity and insulin resistance by targeting pro-in-flammatory cytokines.
C1 [Rakotoarivelo, Volatiana; Variya, Bhavesh; Ilangumaran, Subburaj; Ramanathan, Sheela] Univ Sherbrooke, Fac Med & Hlth Sci, Dept Anat & Cell Biol, 3001 North 12th Ave, Sherbrooke, PQ J1H 5N4, Canada.
   [Rakotoarivelo, Volatiana; Variya, Bhavesh; Ilangumaran, Subburaj; Langlois, Marie-France; Ramanathan, Sheela] CRCHUS, Sherbrooke, PQ, Canada.
   [Langlois, Marie-France] Univ Sherbrooke, Fac Med & Hlth Sci, Dept Med, Sherbrooke, PQ, Canada.
C3 University of Sherbrooke; University of Sherbrooke
RP Ramanathan, S (corresponding author), Univ Sherbrooke, Fac Med & Hlth Sci, Dept Anat & Cell Biol, 3001 North 12th Ave, Sherbrooke, PQ J1H 5N4, Canada.
EM sheela.ramanathan@usherbrooke.ca
RI Variya, Bhavesh/H-5628-2019
OI Ilangumaran, Subburaj/0000-0002-7563-576X; Variya,
   Bhavesh/0000-0002-8734-8186
FU Canadian Institutes of Health Research (CIHR) [MOP86530]
FX This work was supported by Canadian Institutes of Health Research (CIHR,
   MOP86530) to SR and MFL.
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NR 180
TC 13
Z9 13
U1 0
U2 8
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1359-6101
EI 1879-0305
J9 CYTOKINE GROWTH F R
JI Cytokine Growth Factor Rev.
PD DEC
PY 2018
VL 44
BP 28
EP 37
DI 10.1016/j.cytogfr.2018.10.001
PG 10
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA HF1DA
UT WOS:000453904500004
PM 30301598
DA 2025-06-11
ER

PT J
AU Crujeiras, AB
   Zulet, MA
   Abete, I
   Amil, M
   Carreira, MC
   Martínez, JA
   Casanueva, FF
AF Crujeiras, A. B.
   Zulet, M. A.
   Abete, I.
   Amil, M.
   Carreira, M. C.
   Martinez, J. A.
   Casanueva, F. F.
TI Interplay of atherogenic factors, protein intake and betatrophin levels
   in obese-metabolic syndrome patients treated with hypocaloric diets
SO INTERNATIONAL JOURNAL OF OBESITY
LA English
DT Article
ID INCREASED CIRCULATING LEVELS; CARDIOVASCULAR RISK-FACTORS;
   ANGIOPOIETIN-LIKE PROTEIN; WEIGHT-LOSS; OXIDATIVE STRESS; GLYCEMIC
   INDEX; GLUCOSE; PLASMA; GHRELIN; OVERWEIGHT
AB CONTEXT: The understanding of the potential role of betatrophin in human metabolic disorders is a current challenge.
   OBJECTIVE: The present research evaluated circulating betatrophin levels in obese patients with metabolic syndrome (MetSyn) features under energy-restricted weight-loss programs and in normal weight in order to establish the putative interplay between the levels of this hormone, diet and metabolic risk factors linked to obesity and associated comorbidities.
   SUBJECTS AND METHODS: One hundred forty-three participants were enrolled in the study (95 obese-MetSyn; age 49.5 +/- 9.4 years; body mass index (BMI) 35.7 +/- 4.5 kgm(-2) and 48 normal weight; age 35.71 +/- 8.8 years; BMI 22.9 +/- 2.2 kgm(-2)). A nutritional therapy consisting in two hypocaloric strategies (control diet based on the AHA recommendations and the RESMENA (MEtabolic Syndrome REduction in Navarra) diet, a novel dietary program with changes in the macronutrient distribution) was only prescribed to obese-MetSyn participants who were randomly allocated to the dietary strategies. Dietary records, anthropometrical and biochemical variables as well as betatrophin levels were analyzed before (pre-intervention, week 0), at 8 weeks (post-intervention, week 8) and after 4 additional months of self-control period (follow-up, week 24).
   RESULTS: Betatrophin levels were higher in obese-MetSyn patients than normal-weight subjects (1.24 +/- 0.43 vs 0.97 +/- 0.69 ng ml(-1), respectively, P = 0.012), and levels were positively associated with body composition, metabolic parameters, leptin and irisin in all participants at baseline. Notably, low pre-intervention (week 0) betatrophin levels in obese patients were significantly associated with higher dietary-induced changes in atherogenic risk factors after 8 weeks. Moreover, protein intake, especially proteins from animal sources, was an independent determinant of betatrophin levels after dietary treatment (B = -0.27; P = 0.012).
   CONCLUSIONS: Betatrophin is elevated in obese patients with MetSyn features and is associated with poorer nutritional outcomes of adiposity and dyslipidemia traits after a weight-loss program. Dietary protein intake could be a relevant modulator of betatrophin secretion and activity.
C1 [Crujeiras, A. B.; Amil, M.; Carreira, M. C.; Casanueva, F. F.] CHUS, Lab Mol & Cellular Endocrinol, Inst Invest Sanitaria IDIS, Santiago De Compostela, Spain.
   [Crujeiras, A. B.; Amil, M.; Carreira, M. C.; Casanueva, F. F.] USC, C Choupana S-N, Santiago De Compostela, Spain.
   [Crujeiras, A. B.; Zulet, M. A.; Abete, I.; Amil, M.; Carreira, M. C.; Martinez, J. A.; Casanueva, F. F.] CIBER Fisiopatol Obesidad & Nutr CIBERobn, Madrid, Spain.
   [Zulet, M. A.; Abete, I.; Martinez, J. A.] Univ Navarra UNAV, Dept Nutr Food Sci & Physiol, C Irunlarrea 1, Pamplona 31008, Spain.
   CHUS, Mol & Cellular Endocrinol Area Lab 2, Inst Invest Sanitaria IDIS, C Choupana S-N, Santiago De Compostela 15706, Spain.
C3 Complexo Hospitalario Universitario de Santiago de Compostela;
   Universidade de Santiago de Compostela; CIBER - Centro de Investigacion
   Biomedica en Red; CIBEROBN; University of Navarra; Complexo Hospitalario
   Universitario de Santiago de Compostela
RP Crujeiras, AB (corresponding author), USC, C Choupana S-N, Santiago De Compostela, Spain.; Martínez, JA (corresponding author), Univ Navarra UNAV, Dept Nutr Food Sci & Physiol, C Irunlarrea 1, Pamplona 31008, Spain.; Crujeiras, AB (corresponding author), CHUS, Mol & Cellular Endocrinol Area Lab 2, Inst Invest Sanitaria IDIS, C Choupana S-N, Santiago De Compostela 15706, Spain.
EM anabelencrujeiras@hotmail.com; jalfmtz@unav.es
RI Zulet, M. Angeles/H-1317-2017; Abete, Itziar/H-4827-2017; Crujeiras, Ana
   B/ABA-8866-2021
OI Zulet, M. Angeles/0000-0002-3926-0892; Abete,
   Itziar/0000-0002-6475-5387; Crujeiras, Ana B/0000-0003-4392-0301
FU Fondo de Investigacion Sanitaria; INTRASALUD programme [PI10/02464];
   Instituto de Salud Carlos III (ISCIII); Health Department of the
   Government of Navarra [48/2009]; Xunta de Galicia, Spain; Linea Especial
   'Nutrition, Obesity and Health' (University of Navarra) [LE/97]
FX We thank all the subjects who participated in this study and the
   research group implicated in the RESMENA project, especially the people
   who performed the field work (R de la Iglesia, P Lopez-Legarrea, S Perez
   and BE Martinez de Morentin). This work was supported by grants from the
   Fondo de Investigacion Sanitaria, INTRASALUD programme (PI10/02464),
   Instituto de Salud Carlos III (ISCIII), and the Health Department of the
   Government of Navarra (48/2009) and Xunta de Galicia, Spain and Linea
   Especial 'Nutrition, Obesity and Health' (University of Navarra LE/97).
   CIBERobn is an initiative of the ISCIII, Spain.
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NR 43
TC 39
Z9 42
U1 0
U2 9
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0307-0565
EI 1476-5497
J9 INT J OBESITY
JI Int. J. Obes.
PD MAR
PY 2016
VL 40
IS 3
BP 403
EP 410
DI 10.1038/ijo.2015.206
PG 8
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA DG1BF
UT WOS:000371799300003
PM 26443337
OA Bronze
DA 2025-06-11
ER

PT J
AU Lin, YC
   Hsieh, IC
   Chen, PC
AF Lin, Yu-Cheng
   Hsieh, I-Chun
   Chen, Pau-Chung
TI UTILIZING THE METABOLIC SYNDROME COMPONENT COUNT IN WORKERS' HEALTH
   SURVEILLANCE: AN EXAMPLE OF DAY-TIME VS. DAY-NIGHT ROTATING SHIFT
   WORKERS
SO INTERNATIONAL JOURNAL OF OCCUPATIONAL MEDICINE AND ENVIRONMENTAL HEALTH
LA English
DT Article
DE Metabolic syndrome; Day-and-night rotating shift work; Occupational
   health; Physical examination
ID SLEEP-APNEA SYNDROME; FATTY LIVER; LIFE-STYLE; OXIDATIVE STRESS;
   RISK-FACTORS; ASSOCIATION; DISEASE; PREVALENCE; PROGRAM; IMPACT
AB Objectives: To establish a practical method for assessing the general metabolic health conditions among different employee groups, this study utilized the total count of metabolic syndrome (MetS) elements as a parameter, and performed a retrospective analysis comparing changes of MetS component count (MSC) of 5 years among day-time work (DW) and day-and-night rotating shift work (RSW) employees. Material and Methods: The data of personal histories, physical examinations, blood tests, abdominal sonographic examinations and occupational records were collected from a cohort of workers in an electronics manufacturing company. We first defined the arithmetic mean value of MSC as MSC density (MSCD) for the employee group; then we compared the changes of MSCD over 5 years between DW and RSW workers. Occupational, personal and health records were analyzed for the 1077 workers with an initial mean age of 32.4 years (standard deviation (SD): 6.2 years), including 565 RSW workers (52%). Results: The initial MSCDs were 1.26 and 1.12 (p = 0.06) for DW and RSW workers, respectively; after 5 years, the increments of MSCD for DW and RSW workers were 0.10 and 0.39, respectively (p < 0.01). By performing multivariate logistic regression analyses, and comparing with DW co-workers, final results indicated that the workers exposed to RSW have 1.7-fold increased risk of elevated MSCD (95% confidence interval (CI): 1.28-2.25, p < 0.01); and are 38% less likely (adjusted rate ratio (aRR) 0.62, 95% CI: 0.45-0.86, p < 0.01) to attain decreased MSCD. Conclusions: These observations demonstrate that changes of MSCD are significantly different between DW and RSW workers, and are increasingly associated with RSW exposure. In conclusion, MSCD can represent the general metabolic health conditions of a given employee group; MSC, MSCD and their transitional changes can be applied as simple and standardized tools for monitoring metabolic health risk profiles when managing employee health, at both the individual and company levels.
C1 [Lin, Yu-Cheng] En Chu Kong Hosp, Dept Occupat Med, New Taipei, Taiwan.
   [Lin, Yu-Cheng] Fu Jen Catholic Univ, Sch Med, New Taipei, Taiwan.
   [Hsieh, I-Chun] Taiwan Adventist Hosp, Dept Environm & Occupat Med, Taipei, Taiwan.
   [Chen, Pau-Chung] Natl Taiwan Univ, Coll Publ Hlth, Inst Occupat Med & Ind Hyg, Room 733,17 Syujhou Rd, Taipei 10055, Taiwan.
C3 Fu Jen Catholic University; National Taiwan University
RP Chen, PC (corresponding author), Natl Taiwan Univ, Coll Publ Hlth, Inst Occupat Med & Ind Hyg, Room 733,17 Syujhou Rd, Taipei 10055, Taiwan.
EM gphinx@gmail.com
RI Liu, Chia-Ju/AAX-8643-2021; Chen, Pau-Chung/H-5686-2011
OI Chen, Pau-Chung/0000-0002-6242-5974
FU Tao-Yuan General Hospital; Center of Health Management
FX The authors would like to acknowledge the personnel of the Center of
   Health Management, Tao-Yuan General Hospital for their full support and
   generous assistance.
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NR 74
TC 13
Z9 15
U1 0
U2 11
PU NOFER INST OCCUPATIONAL MEDICINE, POLAND
PI LODZ
PA SW TERESY 8, LODZ, 91-348, POLAND
SN 1232-1087
EI 1896-494X
J9 INT J OCCUP MED ENV
JI Int. J. Occup. Med. Environ. Health
PY 2015
VL 28
IS 4
BP 675
EP 688
DI 10.13075/ijomeh.1896.00335
PG 14
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA CO2NS
UT WOS:000358993900003
PM 26216307
OA Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Frisbee, JC
   Hollander, JM
   Brock, RW
   Yu, HG
   Boegehold, MA
AF Frisbee, Jefferson C.
   Hollander, John M.
   Brock, Robert W.
   Yu, Han-Gang
   Boegehold, Matthew A.
TI Integration of skeletal muscle resistance arteriolar reactivity for
   perfusion responses in the metabolic syndrome
SO AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE
   PHYSIOLOGY
LA English
DT Article
DE peripheral vascular disease; microcirculation; regional blood flow;
   obesity
ID OBESE ZUCKER RATS; IMPAIRED FUNCTIONAL VASODILATION; REDUCED
   OXYGEN-TENSION; HAMSTER FEED ARTERIES; MEDIATED VASOCONSTRICTION;
   PROSTACYCLIN SYNTHASE; TYROSINE NITRATION; SIGNALING PATHWAYS; DILATION;
   FLOW
AB Frisbee JC, Hollander JM, Brock RW, Yu HG, Boegehold MA. Integration of skeletal muscle resistance arteriolar reactivity for perfusion responses in the metabolic syndrome. Am J Physiol Regul Integr Comp Physiol 296: R1771-R1782, 2009. First published April 22, 2009; doi:10.1152/ajpregu.00096.2009.-Previous study suggests that with evolution of the metabolic syndrome, patterns of arteriolar reactivity are profoundly altered and may constrain functional hyperemia. This study investigated interactions between parameters of vascular reactivity at two levels of resistance arterioles in obese Zucker rats (OZR), translating these observations into perfusion regulation for in situ skeletal muscle. Dilation of isolated and in situ resistance arterioles from OZR to acetylcholine, arachidonic acid (AA), and hypoxia (isolated arterioles only) were blunted vs. lean Zucker rats (LZR), although dilation to adenosine was intact. Increased adrenergic tone (phenylephrine) or intralumenal pressure (ILP) impaired dilation in both strains (OZR>LZR). Treatment of OZR arterioles with Tempol (superoxide dismutase mimetic) or SQ-29548 (prostaglandin H-2/thromboxane A(2) receptor antagonist) improved dilator reactivity under control conditions and with increased ILP, but had minimal effect with increased adrenergic tone. Arteriolar dilation to adenosine was well maintained in both strains under all conditions. For in situ cremasteric arterioles, muscle contraction-induced elevations in metabolic demand elicited arteriolar dilations and hyperemic responses that were blunted in OZR vs. LZR, although distal parallel arterioles were characterized by heterogeneous dilator and perfusion responses. alpha-Adrenoreceptor blockade improved outcomes at rest but had minimal effect with elevated metabolic demand. Treatment with Tempol or SQ-29548 had minimal impact at rest, but lessened distal arteriolar perfusion heterogeneity with increased metabolic demand. In blood-perfused gastrocnemius of OZR, perfusion was constrained primarily by adrenergic tone, while myogenic activation and endothelium-dependent dilation did not appear to contribute significantly to ischemia. These results of this novel, integrated approach suggest that adrenergic tone and metabolic dilation are robust determinants of bulk perfusion to skeletal muscle of OZR, while endothelial dysfunction may more strongly regulate perfusion distribution homogeneity via the impact of oxidant stress and AA metabolism.
C1 [Frisbee, Jefferson C.; Brock, Robert W.; Yu, Han-Gang; Boegehold, Matthew A.] W Virginia Univ, Sch Med, Robert C Byrd Hlth Sci Ctr, Ctr Cardiovasc & Resp Sci,Dept Physiol & Pharmaco, Morgantown, WV 26505 USA.
   [Hollander, John M.] W Virginia Univ, Sch Med, Div Exercise Physiol, Morgantown, WV 26505 USA.
C3 West Virginia University; West Virginia University
RP Frisbee, JC (corresponding author), W Virginia Univ, Sch Med, Robert C Byrd Hlth Sci Ctr, Ctr Cardiovasc & Resp Sci,Dept Physiol & Pharmaco, POB 9105, Morgantown, WV 26505 USA.
EM jfrisbee@hsc.wvu.edu
OI Frisbee, Jefferson/0000-0003-2751-0599; Yu, Han-Gang/0000-0001-6838-8310
FU National Institute of Diabetes and Digestive and Kidney Diseases
   [R01-DK-64668]; American Heart Association [SDG-0330194N, EIA-0740129N]
FX This work was supported by National Institute of Diabetes and Digestive
   and Kidney Diseases Grant R01-DK-64668 and American Heart Association
   Grants SDG-0330194N and EIA-0740129N.
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NR 39
TC 28
Z9 34
U1 0
U2 0
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0363-6119
EI 1522-1490
J9 AM J PHYSIOL-REG I
JI Am. J. Physiol.-Regul. Integr. Comp. Physiol.
PD JUN
PY 2009
VL 296
IS 6
BP R1771
EP R1782
DI 10.1152/ajpregu.00096.2009
PG 12
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA 448FE
UT WOS:000266247700012
PM 19386988
OA Green Published
DA 2025-06-11
ER

PT J
AU Brown, A
   Carrington, MJ
   McGrady, M
   Lee, G
   Zeitz, C
   Krum, H
   Rowley, K
   Stewart, S
AF Brown, Alex
   Carrington, Melinda J.
   McGrady, Michele
   Lee, Geraldine
   Zeitz, Christopher
   Krum, Henry
   Rowley, Kevin
   Stewart, Simon
TI Cardiometabolic risk and disease in Indigenous Australians: The heart of
   the heart study
SO INTERNATIONAL JOURNAL OF CARDIOLOGY
LA English
DT Article
DE Indigenous; Cardiovascular disease; Cardiometabolic; Non-communicable
   disease; Depression; Socioeconomic factors
ID CARDIOVASCULAR-DISEASE; RENAL-DISEASE; HEALTH; FAILURE; PEOPLES; PAIN
AB Objectives: This study assessed the burden and determinants of cardiovascular and metabolic risk in a community sample of high risk Indigenous Australians. Background: Indigenous Australians are over-represented in the most disadvantaged strata of Australian society. The role of psychosocial and socioeconomic factors in patterning cardiometabolic disease in this population is unclear.
   Methods: The Heart of the Heart Study was a cross sectional study of 436 Aboriginal adults from remote, urban and peri-urban communities around Alice Springs (Northern Territory, Australia). Participants underwent detailed assessments of socio-demographic, psychosocial, cardiovascular and metabolic status.
   Results: Individuals with depression were twice as likely to have cardiovascular disease (OR 2.03; 1.07-3.88; p < 0.05). Chronic kidney disease (39.7%, 37.2% and 18.2%) and diabetes (28.4%, 34.0% and 19.2%) were more common in peri-urban and remote compared to urban communities. Cardiovascular disease did not vary across locations (p = 0.069), but coronary artery disease did (p = 0.035 for trend). Unemployed individuals were more likely to have cardiovascular disease (OR 2.32; 1.33-4.06; p < 0.001). Socioeconomic gradients in coronary artery disease, all cardiovascular disease and diabetes, as measured by income, operated differentially across locations (p for location/socioeconomic status interactions 0.002; 0.01 and 0.04 respectively).
   Conclusion: Participants had high rates of pre-existing cardiovascular disease, diabetes and chronic kidney disease. Cardiovascular risk in these communities was associated with psychosocial factors and socioeconomic indicators. However, gradients operated differentially across location. These data provide a strong foundation for better understanding key drivers of increased levels of cardiovascular and other common forms of noncommunicable disease in Indigenous people. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
C1 [Brown, Alex] Baker IDI Heart & Diabet Inst, Alice Springs, NT, Australia.
   [Brown, Alex] South Australian Hlth & Med Res Inst, Adelaide, SA 5000, Australia.
   [Carrington, Melinda J.; Lee, Geraldine; Stewart, Simon] Baker IDI Heart & Diabet Inst, Melbourne, Vic, Australia.
   [McGrady, Michele; Krum, Henry] Monash Univ, Sch Publ Hlth & Prevent Med, Clayton, Vic 3800, Australia.
   [Zeitz, Christopher] Univ Adelaide, Sch Med, Adelaide, SA, Australia.
   [Rowley, Kevin] Univ Melbourne, Melbourne Sch Populat Hlth, Melbourne, Vic, Australia.
C3 Baker Heart and Diabetes Institute; South Australian Health & Medical
   Research Institute (SAHMRI); Baker Heart and Diabetes Institute; Monash
   University; University of Adelaide; University of Melbourne
RP Brown, A (corresponding author), South Australian Hlth & Med Res Inst, POB 11060, Adelaide, SA 5000, Australia.
EM alex.brown@sahmri.com
RI Lee, Geraldine/S-6017-2019; Brown, Alex/E-8614-2010; Krum,
   Henry/I-2232-2014; Stewart, Simon/M-3316-2016
OI Brown, Alex/0000-0003-2112-3918; Lee, Geraldine/0000-0001-6385-8600;
   Zeitz, Christopher/0000-0001-8045-6873; Stewart,
   Simon/0000-0001-9032-8998
FU National Heart Foundation of Australia (Melbourne, VIC); J. T. Reid
   Trust (Melbourne, VIC); Cardiovascular Lipids Research Grants (Sydney,
   NSW); National Heart Foundation [PR 08M 4207]; Viertel Senior Medical
   Research Fellowship (Brisbane, QLD); NHMRC Senior Research Fellowships
   (Canberra, ACT); NHMRC; NHMRC/NHF (Sydney, NSW) scholarship; CSANZ
   (Sydney, NSW) scholarship
FX This study was funded by the National Heart Foundation of Australia
   (Melbourne, VIC), J. T. Reid Trust (Melbourne, VIC), and Cardiovascular
   Lipids Research Grants (Sydney, NSW). Professor Brown was supported by a
   Fellowship from the National Heart Foundation (PR 08M 4207) and is
   currently supported by a Viertel Senior Medical Research Fellowship
   (Brisbane, QLD); Professor Stewart and Dr Rowley by NHMRC Senior
   Research Fellowships (Canberra, ACT); Dr Carrington by a NHMRC
   Postdoctoral Research Fellowship and Dr McGrady's by NHMRC/NHF and CSANZ
   (Sydney, NSW) scholarships.
CR Adler NE, 2010, ANN NY ACAD SCI, V1186, P5, DOI 10.1111/j.1749-6632.2009.05337.x
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   Australian Institute of Health and Welfare, 2006, CHRON DIS ASS RISK F
   Australian Institute of Health and Welfare, 2011, CONTR CHRON DIS GAP
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   National Vascular Disease Prevention Alliance, 2009, GUID ASS ABS CARD DI
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NR 36
TC 33
Z9 34
U1 0
U2 20
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0167-5273
EI 1874-1754
J9 INT J CARDIOL
JI Int. J. Cardiol.
PD FEB 15
PY 2014
VL 171
IS 3
BP 377
EP 383
DI 10.1016/j.ijcard.2013.12.026
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Cardiovascular System & Cardiology
GA 296LX
UT WOS:000330187700039
PM 24388543
DA 2025-06-11
ER

PT J
AU Fei, QM
   Tan, Y
   Yi, MH
   Zhao, WC
   Zhang, Y
AF Fei, Quanming
   Tan, Yun
   Yi, Minhan
   Zhao, Wangcheng
   Zhang, Yuan
TI Associations between cardiometabolic phenotypes and levels of TNF-α,
   CRP, and interleukins in obstructive sleep apnea
SO SLEEP AND BREATHING
LA English
DT Article
DE Obstructive sleep apnea; Cardiometabolic phenotypes; CRP; TNF-alpha;
   IL-6
ID C-REACTIVE PROTEIN; INFLAMMATORY MARKERS; CARDIOVASCULAR RISK; METABOLIC
   SYNDROME; SYSTEMIC INFLAMMATION; OXIDATIVE STRESS; BLOOD-PRESSURE;
   HYPERTENSION; GENDER; OBESITY
AB Purpose Obstructive sleep apnea (OSA) shows a chronic inflammatory state which is often accompanied by cardiometabolic phenotypes. The aim of this study was to investigate whether or not there were differences of inflammatory proteins levels in patients with OSA with and without a certain phenotype so as to explore the associations between inflammation and additional OSA phenotypes.
   Methods The literature was systematically screened and available data were collected on levels of tumor necrosis factor-alpha (TNF-alpha), C-reactive protein (CRP), and several interleukins (ILs) in patients with OSA with and without a certain phenotype. Overall effect size of standard mean difference (SMD) was used to compare the expression of differences between the two groups. Data analysis was conducted by Review Manager 5.3, and the threshold of p value was set as <0.05.
   Results A total of 31 articles were included, covering five traits of obesity, hypertension (HBP), metabolic syndrome (MS), heart disease, and sex. There were elevated levels of TNF-alpha (SMD = 0.63, p = 0.03), CRP (SMD = 0.64, p = 0.0001), and IL-6 (SMD = 0.83, p = 0.008) levels in OSA with obesity. Also, OSA with HBP showed significant increases of TNF-alpha (SMD = 0.36, p = 0.02), CRP (SMD = 0.98, p = 0.01), and IL-6 (SMD= 0.76, p < 0.0001) levels. A higher CRP level was also observed in OSA with MS (SMD = 0.31, p = 0.004) and female sex (SMD = 0.21, p = 0.002). There were no statistical differences for IL-alpha (p = 0.22) and CRP (p = 0.14) levels of OSA with obesity and heart disease respectively compared with OSA without corresponding phenotype. TNF-alpha (p = 0.66) and IL-6 (p = 0.49) levels also lacked statistically significant differences between female and male patients with OSA.
   Conclusions Our results revealed that inflammatory proteins TNF-alpha, CRP, and IL-6 levels were higher in obese and hypertensive patients with OSA and CRP levels were higher in OSA with metabolic syndrome, highlighting a link between inflammation and cardiometabolic complications in patients with OSA.
C1 [Fei, Quanming; Tan, Yun; Yi, Minhan; Zhao, Wangcheng; Zhang, Yuan] Cent South Univ, Xiangya Hosp, Dept Resp Med, Changsha, Hunan, Peoples R China.
   [Tan, Yun; Yi, Minhan] Cent South Univ, Sch Life Sci, Changsha, Hunan, Peoples R China.
   [Fei, Quanming; Tan, Yun; Yi, Minhan; Zhang, Yuan] Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha, Hunan, Peoples R China.
   [Fei, Quanming; Zhao, Wangcheng] Cent South Univ, Xiangya Sch Med, Changsha, Peoples R China.
C3 Central South University; Central South University; Central South
   University; Central South University
RP Zhang, Y (corresponding author), Cent South Univ, Xiangya Hosp, Dept Resp Med, Changsha, Hunan, Peoples R China.; Zhang, Y (corresponding author), Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha, Hunan, Peoples R China.
EM zhangyuan9194@csu.edu.cn
RI /HIU-0766-2022
OI /0000-0003-0577-7129
FU National Natural Science Foundation of China [82001357]; Hunan
   Provincial Natural Science Foundation of China [2021JJ80079]; Youth
   Science Foundation of Xiangya Hospital [2019Q17]; Degree & Postgraduate
   Education Reform Project of Central South University [2021YJSKSA10];
   Undergraduate Education Reform Project of Central South University
   [2021CG065, 2021CG068]; Research Project of Laboratory Construction and
   Management of Central South University [202120]; Academy of Finland
   (AKA) [202120] Funding Source: Academy of Finland (AKA)
FX This research was supported by the National Natural Science Foundation
   of China (No. 82001357), the Hunan Provincial Natural Science Foundation
   of China (No. 2021JJ80079), the Youth Science Foundation of Xiangya
   Hospital (No. 2019Q17), the Degree & Postgraduate Education Reform
   Project of Central South University (No. 2021YJSKSA10), the
   Undergraduate Education Reform Project of Central South University (No.
   2021CG065, No. 2021CG068), and the Research Project of Laboratory
   Construction and Management of Central South University (No. 202120).
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NR 68
TC 9
Z9 9
U1 0
U2 18
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1520-9512
EI 1522-1709
J9 SLEEP BREATH
JI Sleep Breath.
PD JUN
PY 2023
VL 27
IS 3
BP 1033
EP 1042
DI 10.1007/s11325-022-02697-w
EA AUG 2022
PG 10
WC Clinical Neurology; Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Respiratory System
GA H9LQ7
UT WOS:000841690200001
PM 35982289
DA 2025-06-11
ER

PT J
AU Lo, K
   Yang, JL
   Chen, CL
   Liu, L
   Huang, YQ
   Feng, YQ
   Yang, AM
AF Lo, Kenneth
   Yang, Jing-Li
   Chen, Chao-Lei
   Liu, Lin
   Huang, Yu-Qing
   Feng, Ying-Qing
   Yang, Ai-Min
TI Associations between blood and urinary manganese with metabolic syndrome
   and its components: Cross-sectional analysis of National Health and
   Nutrition Examination Survey 2011-2016
SO SCIENCE OF THE TOTAL ENVIRONMENT
LA English
DT Article
DE Dyslipidemias; Hypertension; Manganese; Metabolic syndrome; Metals;
   Obesity
ID LABORATORY IMPROVEMENT AMENDMENTS; CLINICAL LABORATORIES;
   FEDERAL-REGULATION; DIABETES-MELLITUS; OXIDATIVE STRESS; KOREAN ADULTS;
   RISK; INFLAMMATION; PREVALENCE; REGRESSION
AB Manganese (Mn) may improve cardiometabolic health with its anti-oxidative ability. However, epidemiological evidence on the overall and sex-specific relationship between Mn exposure and metabolic syndrome (MetS) has been inconclusive. We evaluated the associations of urinary (n = 1713) and blood (n = 3335) Mn levels with the prevalence of MetS, its components (elevated waist circumference, impaired glucose metabolism, elevated blood pressure and dyslipidemia) and sex-dependent heterogeneities among participants in the United States National Health and Nutrition Examination Survey 2011-2016. After adjusting for multiple covariates and the levels of other metals (Arsenic, Barium, Cadmium, Mercury, Molybdenum, Tin and Uranium), urinary Mn at the third quartile associated with a lower odd of MetS (odds ratio [OR] = 0.55, 95% confidence interval [C.I.] = 0.32-0.97), elevated waist circumference (OR = 0.56, 95% C.I. = 0.36-0.86) and elevated fasting plasma glucose (OR = 0.46, 95% C.I. = 0.27-0.76) among overall participants, and lower odds of MetS (OR = 0.40, 95% C.I. = 0.16-0.99), elevated waist circumference (OR = 0.39, 95% C.I. = 0.19-0.81) and elevated fasting plasma glucose (OR = 0.44, 95% C.I. = 0.22-0.90) among men. The U-shaped dose-response relationship between urinary Mn and MetS (P non-linear = 0.008) was observed among all participants. We did not observe the significant associations of blood Mn with the prevalence of MetS. Compared with other metals, urinary Mn played a less important role in development of MetS (posterior inclusion probabilities [PIP] = 0.49 for Mn versus 0.54 to 0.91 for other metals), but the contribution of blood Mn (PIP = 0.59 versus 0.60 to 0.61) was similar to other blood metals (Cadmium, Lead, Mercury and Selenium). These findings have provided new evidence of the potential roles of Mn in cardiometabolic health, and the needs to explore how Mn interacts with multiple metals in sex-specific manner.
   (c) 2021 Elsevier B.V. All rights reserved.
C1 [Lo, Kenneth; Chen, Chao-Lei; Liu, Lin; Huang, Yu-Qing; Feng, Ying-Qing] Guangdong Acad Med Sci, Guangdong Prov Peoples Hosp, Dept Cardiol, Guangzhou, Peoples R China.
   [Lo, Kenneth] Brown Univ, Ctr Global Cardiometab Hlth, Dept Epidemiol, Providence, RI 02912 USA.
   [Lo, Kenneth] Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Hung Hom, Hong Kong, Peoples R China.
   [Yang, Jing-Li] Lanzhou Univ, Sch Publ Hlth, Dept Epidemiol & Stat, Coll Earth & Environm Sci, Lanzhou, Gansu, Peoples R China.
   [Yang, Ai-Min] Chinese Univ Hong Kong, Hong Kong Inst Diabet & Obes, Hong Kong, Peoples R China.
C3 Guangdong Academy of Medical Sciences & Guangdong General Hospital;
   Southern Medical University - China; Brown University; Hong Kong
   Polytechnic University; Lanzhou University; Chinese University of Hong
   Kong
RP Feng, YQ (corresponding author), Guangdong Acad Med Sci, Guangdong Prov Peoples Hosp, Dept Cardiol, Guangzhou, Peoples R China.; Yang, AM (corresponding author), Chinese Univ Hong Kong, Hong Kong Inst Diabet & Obes, Hong Kong, Peoples R China.
EM 651792209@qq.com; aiminyang@cuhk.edu.hk
RI Huang, YQ/JOK-7580-2023; Yang, Jingli/GON-7161-2022; Lo,
   Kenneth/ABB-6248-2020; Yang, Aimin/D-8344-2015; , Kenneth/C-6537-2014
OI Yang, Jingli/0000-0003-0773-494X; , Kenneth/0000-0003-4624-2737
FU National Key Research and Development Program of China [2017YFC1307603]
FX The present study was supported The National Key Research and
   Development Program of China (Grant Number: 2017YFC1307603).
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NR 53
TC 31
Z9 32
U1 0
U2 44
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0048-9697
EI 1879-1026
J9 SCI TOTAL ENVIRON
JI Sci. Total Environ.
PD AUG 1
PY 2021
VL 780
AR 146527
DI 10.1016/j.scitotenv.2021.146527
EA MAR 2021
PG 9
WC Environmental Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology
GA SF9TN
UT WOS:000653089300006
PM 33774283
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Söder, J
   Bröjer, JT
   Nostell, KEA
AF Soder, Josefin
   Brojer, Johan T.
   Nostell, Katarina E. A.
TI Interday variation and effect of transportation on indirect blood
   pressure measurements, plasma endothelin-1 and serum cortisol in
   Standardbred and Icelandic horses
SO ACTA VETERINARIA SCANDINAVICA
LA English
DT Article
DE Horse; Plasma endothelin-1; Cortisol; Blood pressure; Transportation
ID METABOLIC SYNDROME; INSULIN SENSITIVITY; GLUCOSE; RESISTANCE; PONIES
AB Background: Systemic hypertension is a prominent feature in humans with metabolic syndrome (MS) and this is partly caused by an enhanced endothelin-1 (ET-1) mediated vasoconstriction. There are indications that systemic hypertension might be a feature in equine metabolic syndrome (EMS) but if ET-1 is involved in the development of hypertension in horses is not known. Increased levels of cortisol have also been found in humans with MS but there are no reports of this in horses. Before blood pressure, plasma ET-1 and serum cortisol can be evaluated in horses with EMS, it is necessary to investigate the interday variation of these parameters on clinically healthy horses. The aims of the present study were therefore to evaluate the interday variation and influence of transportation on systemic blood pressure, plasma ET-1 and serum cortisol in healthy Standardbred and Icelandic horses, and to detect potential breed differences.
   Methods: Nine horses of each breed were included in the study. Blood pressure was measured and blood samples were collected between 6 and 9 am on two separate days. Eight of the horses (four of each breed) were transported to a new stable were they stayed overnight. The next morning, the sampling procedure was repeated.
   Results: The interday variation was higher for plasma ET-1 (37%) than for indirect pressure measurements (8-21%) and serum cortisol (18%). There were no differences in systemic blood pressure between the two breeds. The Icelandic horses had significantly lower serum cortisol and significantly higher plasma ET-1 concentrations compared to the Standardbred horses. Plasma ET-1 was significantly elevated after transportation, but systemic blood pressure and serum cortisol did not differ from the values obtained in the home environment.
   Conclusions: Indirect blood pressure, plasma ET-1 and serum cortisol are of interest as markers for cardiovascular dysfunction in horses with EMS. The elevated plasma ET-1 concentrations recorded after transportation was likely caused by a stress response. This needs to be considered when evaluating plasma ET-1 in horses after transportation. The differences detected in plasma ET-1 and serum cortisol between the two breeds might be related to differences in genetic setup, training status as well as management conditions.
C1 [Soder, Josefin; Brojer, Johan T.; Nostell, Katarina E. A.] Swedish Univ Agr Sci, Dept Clin Sci, S-75007 Uppsala, Sweden.
C3 Swedish University of Agricultural Sciences
RP Nostell, KEA (corresponding author), Swedish Univ Agr Sci, Dept Clin Sci, Box 7054, S-75007 Uppsala, Sweden.
EM Katarina.Nostell@slu.se
OI Soder, Josefin/0000-0001-8505-0274
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NR 39
TC 11
Z9 12
U1 0
U2 22
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0044-605X
EI 1751-0147
J9 ACTA VET SCAND
JI Acta Vet. Scand.
PD JUN 10
PY 2012
VL 54
AR 37
DI 10.1186/1751-0147-54-37
PG 7
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA 041LZ
UT WOS:000311404600002
PM 22682151
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Li, JX
   Song, FJ
AF Li, Junxian
   Song, Fengju
TI A causal relationship between antioxidants, minerals and vitamins and
   metabolic syndrome traits: a Mendelian randomization study
SO DIABETOLOGY & METABOLIC SYNDROME
LA English
DT Article
DE Metabolic syndrome; Antioxidant; Mineral; Vitamin; Mendelian
   randomization
ID GENOME-WIDE ASSOCIATION; OXIDATIVE STRESS; SELENIUM; RISK; MAGNESIUM;
   US; SUPPLEMENTATION; SELENOPROTEINS; METAANALYSIS; POPULATION
AB Background The available evidence regarding the association of antioxidants, minerals, and vitamins with the risk of metabolic syndrome (MetS) traits is currently limited and inconsistent. Therefore, the purpose of this Mendelian randomization (MR) study was to investigate the potential causal relationship between genetically predicted antioxidants, minerals, and vitamins, and MetS.
   Methods In this study, we utilized genetic variation as instrumental variable (IV) to capture exposure data related to commonly consumed dietary nutrients, including antioxidants (beta-carotene, lycopene, and uric acid), minerals (copper, calcium, iron, magnesium, phosphorus, zinc, and selenium), and vitamins (folate, vitamin A, B6, B12, C, D, E, and K1). The outcomes of interest, namely MetS (n = 291,107), waist circumference (n = 462,166), hypertension (n = 463,010), fasting blood glucose (FBG) (n = 281,416), triglycerides (n = 441,016), and high-density lipoprotein cholesterol (HDL-C) (n = 403,943), were assessed using pooled data obtained from the most comprehensive genome-wide association study (GWAS) available. Finally, we applied the inverse variance weighting method as the result and conducted a sensitivity analysis for further validation.
   Results Genetically predicted higher iron (OR = 1.070, 95% CI 1.037-1.105, P = 2.91E-05) and magnesium levels (OR = 1.130, 95% CI 1.058-1.208, P = 2.80E-04) were positively associated with increased risk of MetS. For each component of MetS, higher level of genetically predicted selenium (OR = 0.971, 95% CI 0.957-0.986, P = 1.09E-04) was negatively correlated with HDL-C levels, while vitamin K1 (OR = 1.023, 95% CI 1.012-1.033, P = 2.90E-05) was positively correlated with HDL-C levels. Moreover, genetically predicted vitamin D (OR = 0.985, 95% CI 0.978-0.992, P = 5.51E-5) had a protective effect on FBG levels. Genetically predicted iron level (OR = 1.043, 95% CI 1.022-1.064, P = 4.33E-05) had a risk effect on TG level.
   Conclusions Our study provides evidence that genetically predicted some specific, but not all, antioxidants, minerals, and vitamins may be causally related to the development of MetS traits.
C1 [Li, Junxian] Tianjin Med Univ Canc Inst & Hosp, Natl Clin Res Ctr Canc, Tianjins Clin Res Ctr Canc, Dept Blood Transfus,Key Lab Canc Prevent & Therap, Tianjin, Peoples R China.
   [Li, Junxian; Song, Fengju] Tianjin Med Univ, Tianj Med Univ Canc Inst & Hosp, Dept Epidemiol & Biostat,Tianjins Clin Res Ctr Ca, Key Lab Mol Canc Epidemiol Tianjin,Natl Clin Res, Tianjin, Peoples R China.
C3 Tianjin Medical University; Tianjin Medical University
RP Song, FJ (corresponding author), Tianjin Med Univ, Tianj Med Univ Canc Inst & Hosp, Dept Epidemiol & Biostat,Tianjins Clin Res Ctr Ca, Key Lab Mol Canc Epidemiol Tianjin,Natl Clin Res, Tianjin, Peoples R China.
EM songfengju@163.com
RI Li, Junxian/GZM-5940-2022
FU Tianjin Key Medical Discipline (Specialty) Construction Project
   [TJYXZDXK-009A]; National Key R&D Program of China [2021YFC2500400];
   National Natural Science Foundation of China [81974439]
FX This study was supported by the Tianjin Key Medical Discipline
   (Specialty) Construction Project [Grants TJYXZDXK-009A], National Key
   R&D Program of China [Grants 2021YFC2500400] and National Natural
   Science Foundation of China [Grants 81974439].
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NR 68
TC 7
Z9 7
U1 0
U2 5
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1758-5996
J9 DIABETOL METAB SYNDR
JI Diabetol. Metab. Syndr.
PD OCT 10
PY 2023
VL 15
IS 1
AR 194
DI 10.1186/s13098-023-01174-y
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA LR0K5
UT WOS:001188409500001
PM 37817280
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Gluvic, Z
   Obradovic, M
   Manojlovic, M
   Giglio, RV
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   Suri, JS
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   Isenovic, ER
AF Gluvic, Zoran
   Obradovic, Milan
   Manojlovic, Mia
   Giglio, Rosaria Vincenza
   Patti, Angelo Maria
   Ciaccio, Marcello
   Suri, Jasjit S.
   Rizzo, Manfredi
   Isenovic, Esma R.
TI Impact of different hormones on the regulation of nitric oxide in
   diabetes
SO MOLECULAR AND CELLULAR ENDOCRINOLOGY
LA English
DT Article
DE NO; Insulin; IGF-1; Estradiol; Irisin; Diabetes
ID GROWTH-FACTOR-I; CARDIAC CONTRACTILE DYSFUNCTION; IMPROVES ENDOTHELIAL
   FUNCTION; STIMULATED INSULIN-SECRETION; PERIVASCULAR ADIPOSE-TISSUE;
   SMOOTH-MUSCLE-CELLS; HEPATIC BLOOD-FLOW; NF-KAPPA-B; METABOLIC SYNDROME;
   OXIDATIVE STRESS
AB Polymetabolic syndrome achieved pandemic proportions and dramatically influenced public health systems functioning worldwide. Chronic vascular complications are the major contributors to increased morbidity, disability, and mortality rates in diabetes patients. Nitric oxide (NO) is among the most important vascular bed function regulators. However, NO homeostasis is significantly deranged in pathological conditions. Additionally, different hormones directly or indirectly affect NO production and activity and subsequently act on vascular physiology. In this paper, we summarize the recent literature data related to the effects of insulin, estradiol, insulin-like growth factor-1, ghrelin, angiotensin II and irisin on the NO regulation in physiological and diabetes circumstances.
C1 [Gluvic, Zoran] Univ Belgrade, Univ Clin Hosp Ctr Zemun Belgrade, Fac Med, Clin Internal Med,Dept Endocrinol & Diabet, Belgrade, Serbia.
   [Obradovic, Milan; Isenovic, Esma R.] Univ Belgrade, VINCA Inst Nucl Sci, Natl Inst Republ Serbia, Dept Radiobiol & Mol Genet, Belgrade, Serbia.
   [Manojlovic, Mia] Univ Novi Sad, Fac Med Novi Sad, Novi Sad, Serbia.
   [Manojlovic, Mia] Clin Ctr Vojvodina, Clin Endocrinol Diabet & Metab Disorders, Novi Sad, Serbia.
   [Giglio, Rosaria Vincenza; Ciaccio, Marcello] Univ Palermo, Dept Biomed Neurosci & Adv Diagnost, Palermo, Italy.
   [Giglio, Rosaria Vincenza; Ciaccio, Marcello] Univ Hosp, Dept Lab Med, Palermo, Italy.
   [Patti, Angelo Maria] Univ Palermo, Internal Med & Med Specialties, Dept Hlth Promot Sci Maternal & Infantile Care, Palermo, Italy.
   [Suri, Jasjit S.] AtheroPointTM, Stroke Monitoring & Diagnost Div, Roseville, CA 95661 USA.
   [Rizzo, Manfredi] Vittorio Emanuele II Hosp, Internal Med Unit, Castelvetrano, Italy.
C3 University of Belgrade; University of Belgrade; University of Novi Sad;
   University of Palermo; University of Palermo; Azienda Ospedaliera
   Universitaria Policlinico Vittorio Emanuele Presidio Ferraotto
RP Gluvic, Z (corresponding author), Univ Belgrade, Univ Clin Hosp Ctr Zemun Belgrade, Fac Med, Clin Internal Med,Dept Endocrinol & Diabet, Belgrade, Serbia.
EM zorangluvic@yahoo.com
RI RIZZO, MANFREDI/GZL-0551-2022; Obradovic, Milan/AGN-1229-2022;
   Manojlovic, Mia/HNS-2703-2023; GIGLIO, Rosaria Vincenza/IAR-9444-2023;
   S, SELVAMUTHUKUMARAN/S-7628-2017; Isenovic, Esma/D-3017-2009; Gluvic,
   Zoran/Q-5190-2019
OI Gluvic, Zoran/0000-0001-6371-6610
FU Ministry of Education, Science and Technological Development of the
   Republic of Serbia [451-03-66/2024-03/200,017]
FX The Ministry of Education, Science and Technological Development of the
   Republic of Serbia provided financial support for this work under
   Contract No# 451-03-66/2024-03/200,017.
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JI Mol. Cell. Endocrinol.
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DI 10.1016/j.mce.2024.112325
EA JUL 2024
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WC Cell Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Endocrinology & Metabolism
GA YH5S7
UT WOS:001267616700001
PM 38968968
DA 2025-06-11
ER

PT J
AU Kowara, M
   Kasarello, K
   Czarzasta, K
   Opolski, G
   Cudnoch-Jedrzejewska, A
AF Kowara, M.
   Kasarello, K.
   Czarzasta, K.
   Opolski, G.
   Cudnoch-Jedrzejewska, A.
TI Early-life inflammation pathways trigger a cascade leading to
   development of atherosclerotic plaque through the "butterfly effect" -
   An hypothesis
SO MEDICAL HYPOTHESES
LA English
DT Article
ID LOW-GRADE INFLAMMATION; BODY-MASS INDEX; CARDIOVASCULAR RISK; METABOLIC
   SYNDROME; SHEAR-STRESS; CHILDHOOD; MORTALITY; MACROPHAGES; CORONARY;
   DISEASE
AB Atherosclerosis is a common disease whose complications, such as myocardial infarction, are a leading cause of mortality worldwide. Therefore, ideas which try to explain the circumstances of atherosclerotic plaque initiation and progression are warranted. We hypothesize that low-grade inflammation in early life (especially an imbalance between pro- and anti-inflammatory macrophages) triggers a "butterfly effect" within the arterial wall by initiating a sequence of processes that finally leads to atherosclerotic plaque development and progression. Therefore, pharmacological and non-pharmacological interventions aimed to prevent atherosclerosis development should be applied not only in the adult population over 40 years old (according to current American and European guidelines) but should start in early life.
C1 [Kowara, M.; Kasarello, K.; Czarzasta, K.; Cudnoch-Jedrzejewska, A.] Med Univ Warsaw, Dept Expt & Clin Physiol, Lab Ctr Preclin Res, Warsaw, Poland.
   [Kowara, M.; Opolski, G.] Med Univ Warsaw, Dept Cardiol 1, Warsaw, Poland.
C3 Medical University of Warsaw; Medical University of Warsaw
RP Cudnoch-Jedrzejewska, A (corresponding author), 1b,Banacha Str, PL-02097 Warsaw, Poland.
EM agnieszka.cudnoch@wum.edu.pl
RI Cudnoch-Jedrzejewska, Agnieszka/AAU-8663-2020; Kasarełło,
   Kaja/ABH-3532-2020
OI Kowara, Michal/0000-0003-3689-4192; Kasarello, Kaja/0000-0002-0851-0975;
   Czarzasta, Katarzyna/0000-0002-9836-9409; Opolski,
   Grzegorz/0000-0003-4744-2554
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NR 64
TC 2
Z9 2
U1 0
U2 1
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0306-9877
EI 1532-2777
J9 MED HYPOTHESES
JI Med. Hypotheses
PD JAN
PY 2019
VL 122
BP 106
EP 110
DI 10.1016/j.mehy.2018.10.026
PG 5
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA HK3JI
UT WOS:000457812100025
PM 30593390
DA 2025-06-11
ER

PT J
AU Overton, JM
AF Overton, J. M.
TI Phenotyping small animals as models for the human metabolic syndrome:
   thermoneutrality matters
SO INTERNATIONAL JOURNAL OF OBESITY
LA English
DT Article
DE thermogenesis; energy homeostasis; energy expenditure; temperature
   regulation
ID BROWN ADIPOSE-TISSUE; DIET-INDUCED THERMOGENESIS; SYMPATHETIC
   NERVOUS-SYSTEM; BODY-TEMPERATURE; BEHAVIORAL THERMOREGULATION; CALORIC
   RESTRICTION; AMBIENT-TEMPERATURE; BLOOD-PRESSURE; HEART-RATE; AUTONOMIC
   CONTROL
AB It is standard practice in preclinical biomedical research to house mammalian model organisms at an ambient temperature substantially below the thermoneutral zone. These experimental studies are performed using animals that are chronically challenged by mild cold stress. This condition increases food intake, metabolic rate, sympathetic activity, blood pressure and heart rate. Furthermore, this condition alters the behavioral and physiological responses to drug administration, energy restriction and overfeeding. This paper will review these observations, which must be understood in the context of phenotyping small mammals to enhance our understanding of the biology of human disease. International Journal of Obesity (2010) 34, S53-S58; doi:10.1038/ijo.2010.240
C1 Florida State Univ, Coll Med, Dept Biomed Sci, Tallahassee, FL 32306 USA.
C3 State University System of Florida; Florida State University
RP Overton, JM (corresponding author), Florida State Univ, Coll Med, Dept Biomed Sci, Tallahassee, FL 32306 USA.
EM mike.overton@med.fsu.edu
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NR 81
TC 87
Z9 97
U1 0
U2 13
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0307-0565
EI 1476-5497
J9 INT J OBESITY
JI Int. J. Obes.
PD DEC
PY 2010
VL 34
SU 2
BP S53
EP S58
DI 10.1038/ijo.2010.240
PG 6
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 694HS
UT WOS:000285286400008
PM 21151148
DA 2025-06-11
ER

PT J
AU Zhang, JQ
   Tan, LJ
   Jung, H
   Jung, J
   Lee, J
   Lee, GW
   Park, S
   Moon, B
   Choi, K
   Shin, S
AF Zhang, Jiaqi
   Tan, Li-Juan
   Jung, Hyein
   Jung, Jongseok
   Lee, JiYun
   Lee, Gowoon
   Park, Suhyun
   Moon, BoKyung
   Choi, Kyungho
   Shin, Sangah
TI Association of smoking and dietary polycyclic aromatic hydrocarbon
   exposure on the prevalence of metabolic syndrome in Korean adults
SO JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY
LA English
DT Article
DE Polycyclic aromatic hydrocarbons; Metabolic syndrome; Smoking; KNHANES;
   Daily dietary intake
ID CIGARETTE-SMOKING; OXIDATIVE STRESS; ACTIVATION; OBESITY; RISK;
   DYSFUNCTION; RECEPTOR; GLUCOSE; PROFILE; DNA
AB BackgroundPolycyclic aromatic hydrocarbons (PAHs) are environmental pollutants that are potentially hazardous to human health. Dietary exposure is recognized as one of the major pathways of exposure to PAHs among humans. While some PAH exposures have been associated with metabolic syndrome (MetS) in the general population, most epidemiological studies are based on urinary metabolites of a few noncarcinogenic PAHs.ObjectiveTo investigate the association between estimates of dietary exposure to major carcinogenic PAHs and MetS in Korean adults.MethodsMulti-cycle Korean National Health and Nutrition Examination Survey (KNHANES) database (n = 16,015) and PAH measurement data from the total diet survey were employed to estimate daily PAH intake for each participating adult. After adjusting for potential confounders, multinomial logistic regression analysis was used to calculate the odds ratios (ORs) and 95% confidence intervals (CIs) between PAHs and MetS of the participating adults.ResultsBenzo(a)pyrene exposure was associated with an increased risk of MetS in men (OR = 1.30; 95% Cl: 1.03-1.63; P-trend = 0.03). In women, however, only chrysene and low high-density lipoprotein (HDL-c) were positively associated with an increased risk of MetS (OR = 1.24; 95% CI: 1.03-1.48; P-trend = 0.0172). Among men, smokers were at an increased risk for MetS, regardless of whether they were exposed to low or high total PAHs and benzo(a)pyrene levels.SignificanceOur findings suggested that PAHs are associated with the risk of MetS and MetS components in Korean adults. In particular, it was confirmed that smoking may influence the relationship between PAH exposure and MetS.Further prospective cohort studies are required to confirm the causal relationship between PAHs and MetS.Impact statementEpidemiological studies on PAH exposure are often hampered by a lack of reliable exposure estimates, as biomonitoring of urine does not capture exposure to more toxic PAHs. Using multi-cycle KNHANES data and the measurement data from a total diet survey of Korea, we could develop a personalized PAH intake estimate for each participating adult and assessed the association with MetS.
C1 [Zhang, Jiaqi; Tan, Li-Juan; Jung, Hyein; Jung, Jongseok; Lee, JiYun; Moon, BoKyung; Shin, Sangah] Chung Ang Univ, Dept Food & Nutr, Seoul 17546, South Korea.
   [Lee, Gowoon; Park, Suhyun; Choi, Kyungho] Seoul Natl Univ, Grad Sch Publ Hlth, Dept Environm Hlth Sci, Seoul, South Korea.
C3 Chung Ang University; Seoul National University (SNU)
RP Shin, S (corresponding author), Chung Ang Univ, Dept Food & Nutr, Seoul 17546, South Korea.
EM ivory8320@cau.ac.kr
RI Tan, LiJuan/LUW-7908-2024; Lee, Gowoon/IUP-5303-2023; jiaqi,
   zhang/AAH-2609-2021; choi, kyungho/D-5732-2012
OI Lee, Gowoon/0000-0002-5431-6532; TAN, LIJUAN/0000-0002-8970-0884
FU National Research Foundation of Korea (NRF) - Korea government (MSIT)
   [2020R1C1C1014286]; MSIT:Ministry of Science and ICT
FX This research was supported by the National Research Foundation of Korea
   (NRF)grant funded by the Korea government (MSIT) (No.2020R1C1C1014286).
   MSIT:Ministry of Science and ICT.
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NR 59
TC 1
Z9 1
U1 1
U2 19
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 1559-0631
EI 1559-064X
J9 J EXPO SCI ENV EPID
JI J. Expo. Sci. Environ. Epidemiol.
PD SEP
PY 2023
VL 33
IS 5
BP 831
EP 839
DI 10.1038/s41370-023-00541-1
EA APR 2023
PG 9
WC Environmental Sciences; Public, Environmental & Occupational Health;
   Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health; Toxicology
GA T4XG6
UT WOS:000983832500002
PM 37019984
DA 2025-06-11
ER

PT J
AU McCarty, MF
   Assanga, SBI
AF McCarty, Mark F.
   Iloki Assanga, Simon B.
TI Ferulic acid may target MyD88-mediated pro-inflammatory signaling -
   Implications for the health protection afforded by whole grains,
   anthocyanins, and coffee
SO MEDICAL HYPOTHESES
LA English
DT Article
DE Ferulic acid; MyD88; Toll-like receptors; Interleukin-1 receptor; Whole
   grains; Anthocyanins; Coffee
ID DIETARY PHYTOCHEMICAL INDEX; DOSE-RESPONSE METAANALYSIS; NF-KAPPA-B;
   INDUCED DEPRESSIVE BEHAVIOR; TYPE-2 DIABETES-MELLITUS; BETA-CELL
   DYSFUNCTION; NLRP3 INFLAMMASOME; CARDIOVASCULAR-DISEASE;
   INSULIN-RESISTANCE; OXIDATIVE STRESS
AB Higher dietary intakes of anthocyanins have been linked epidemiologically to decreased risk for metabolic syndrome, type 2 diabetes and cardiovascular events; clinical trials and rodent studies evaluating ingestion of anthocyanin-rich extracts confirm favorable effects of these agents on endothelial function and metabolic syndrome. However, these benefits of anthocyanins are lost in rats whose gut microbiome has been eliminated with antibiotic treatment - pointing to bacterial metabolites of anthocyanins as the likely protective agents. A human pharmacokinetic assessment of orally administered cyanidin-3-O-glucoside, a prominent anthocyanin, has revealed that, whereas this compound is minimally absorbed, ferulic acid (FA) is one of its primary metabolites that appears in plasma. FA is a strong antioxidant and phase 2 inducer that has exerted marked anti-inflammatory effects in a number of rodent and cell culture studies; in particular, FA is highly protective in rodent models of diet-induced weight gain and metabolic syndrome. FA, a precursor for lignan synthesis, is widely distributed in plant-based whole foods, mostly in conjugated form; whole grains are a notable source. Coffee ingestion boosts plasma FA owing to gastrointestinal metabolism of chlorogenic acid. Hence, it is reasonable to suspect that FA mediates some of the broad health benefits that have been associated epidemiologically with frequent consumption of whole grains, anthocyanins, coffee, and unrefined plant-based foods. The molecular basis of the anti-inflammatory effects of FA may have been clarified by a recent study demonstrating that FA can target the adaptor protein MyD88; this plays an essential role in pro-inflammatory signaling by most toll-like receptors and interleukin-1 beta. If feasible oral intakes of FA can indeed down-regulate MyD88-dependent signaling, favorable effects of FA on neurodegeneration, hypothalamic inflammation, weight gain, adipocyte and beta cell function, adiponectin secretion, vascular health, and cartilage and bone integrity can be predicted. Since FA is well tolerated, safe, and natural, it may have great potential as a protective nutraceutical, and clinical trials evaluating its effects are needed.
C1 [McCarty, Mark F.] Catalyt Longev, 811 B Nahant Ct, San Diego, CA 92109 USA.
   [Iloki Assanga, Simon B.] Univ Sonora, Dept Ciencias Quim Biol, Hermosillo, Sonora, Mexico.
C3 Universidad de Sonora
RP McCarty, MF (corresponding author), Catalyt Longev, 811 B Nahant Ct, San Diego, CA 92109 USA.
EM markfmccarty@gmail.com
RI ILOKI ASSANGA, SIMON BERNARD/GNP-3218-2022
OI ILOKI ASSANGA, SIMON BERNARD/0000-0002-2058-5881
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NR 189
TC 32
Z9 32
U1 0
U2 55
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0306-9877
EI 1532-2777
J9 MED HYPOTHESES
JI Med. Hypotheses
PD SEP
PY 2018
VL 118
BP 114
EP 120
DI 10.1016/j.mehy.2018.06.032
PG 7
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA GR0FN
UT WOS:000442189900023
PM 30037596
DA 2025-06-11
ER

PT J
AU Cardoso, GA
   Silva, AS
   De Lavor, WH
   Da Silva, GF
   Da Silva, DP
   Mota, MP
AF Cardoso, Glebia A.
   Silva, Alexandre S.
   De Lavor, Willame H.
   Da Silva Junior, Geraldo F.
   Da Silva, Dionede P.
   Mota, Maria P.
TI Resistance exercise does not change components and markers of metabolic
   syndrome in pre- and postmenopausal period
SO MEDICINA DELLO SPORT
LA English
DT Article
DE Menopause; Resistance training; Blood pressure; Body composition;
   Oxidative stress
ID BLOOD-PRESSURE; WOMEN; PROGRAM; HEALTH
AB BACKGROUND: This study investigated the influence of resistance exercise training on components and markers of metabolic syndrome in pre and postmenopausal women.
   METHODS: Forty-three women were randomly divided in trained premenopausal (PRE-MR, N.=9, 44.0 +/- 5 years), trained postmenopausal (POS-MR, N.=11, 54.7 +/- 8 years), control premenopausal (PRE-MC, N.=11, 39.5 +/- 4 years) and control postmenopausal (POS-MC, N.=12, 54.9 +/- 6 years). The training was conducted for 12 weeks, 3-5 sessions per week with progressive loads (10 to 12 repetitions; 50% to 80% of lORM). Blood pressure, glucose, lipid profile and waist circumference, gamma glutamyl transferase and malonildehyde was measured at pre and post training.
   RESULTS: Despite the strength gains seen in trained women, did not change in any of the variables. Values between pre- and post-training periods in PRE-MR and POS-MR respectively were 85.4 +/- 8 mg/dL vs. 86.0 +/- 5 mg/dL and 99.7 +/- 24 mg/dL vs. 91.2 +/- 20 mg/dL to glucose; 192.0 +/- 43 mg/dL vs. 186.5 +/- 44 mg/dL and 212.7 +/- 34 mg/dL vs. 208.9 +/- 37 mg/dL to total lipoproteins; 94.7 +/- 9 cm vs. 92.6 +/- 7 cm and 97.1 +/- 12 cm vs. 94.2 +/- 12 cm to waist circumference. Blood pressure showed descritively reduction (116.0 +/- 14 mmHg vs. 118.0 +/- 10 mmHg and 127.8 +/- 12 mmHg vs. 119.8 +/- 11 mmHg to pre- and postmenopausal respectively). Effect size to postmenopausal was 0.69. Results for markers was 15.8 +/- 4 U/L vs. 14.3 +/- 3 U/L and 15.9 +/- 6 U/L vs.14.8 +/- 5 U/L to gamma glutamyl transferase and 3.7 +/- 1 mu M vs. 4.2 +/- 1 mu M and 2.8 +/- 1 mu M vs. 2.5 +/- 1 mu M to malonildehyde.
   CONCLUSIONS: Twelve weeks of resistance training do not affect blood pressure, glycaemia, body composition or metabolic syndrome markers and lipidic peroxidation in pre and postmenopausal women. However increasing sample size can result in statistical reduction to blood pressure only in postmenopausal woman.
C1 [Cardoso, Glebia A.; Mota, Maria P.] Tras Os Montes Alto Douro Univ, Dept Sport, Vila Real, Portugal.
   [Silva, Alexandre S.] Univ Fed Paraiba, Dept Phys Educ, Joao Pessoa, Paraiba, Brazil.
   [De Lavor, Willame H.; Da Silva Junior, Geraldo F.; Da Silva, Dionede P.] Reg Univ Cariri, Dept Phys Educ, Iguatu, Brazil.
C3 University of Tras-os-Montes & Alto Douro; Universidade Federal da
   Paraiba; Universidade Regional do Cariri
RP Silva, AS (corresponding author), Univ Fed Paraiba, Dept Phys Educ, Ctr Hlth Sci, Lab Study Phys Training Appl Performance & Hlth, Campus 1, BR-58059900 Joao Pessoa, Paraiba, Brazil.
EM alexandresergiosilva@yahoo.com.br
RI Silva, Alexandre Sergio/N-8883-2014
OI Silva, Alexandre Sergio/0000-0003-3576-9023; Mota, Maria
   Paula/0000-0002-7145-243X
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NR 27
TC 6
Z9 6
U1 0
U2 6
PU EDIZIONI MINERVA MEDICA
PI TURIN
PA CORSO BRAMANTE 83-85 INT JOURNALS DEPT., 10126 TURIN, ITALY
SN 0025-7826
EI 1827-1863
J9 MED SPORT
JI Med. Sport
PD MAR
PY 2016
VL 69
IS 1
BP 13
EP 23
PG 11
WC Medicine, General & Internal; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Sport Sciences
GA DY2UV
UT WOS:000384948500003
DA 2025-06-11
ER

PT J
AU Li, LJ
   Garikepati, RM
   Tsukerman, S
   Tiwari, S
   Ecelbarger, CM
AF Li, Lijun
   Garikepati, R. Mayuri
   Tsukerman, Susanna
   Tiwari, S.
   Ecelbarger, Carolyn M.
TI Salt sensitivity of nitric oxide generation and blood pressure in mice
   with targeted knockout of the insulin receptor from the renal tubule
SO AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE
   PHYSIOLOGY
LA English
DT Article
DE metabolic syndrome; sodium excretion; salt sensitivity; insulin
   resistance
ID PROXIMAL CONVOLUTED TUBULE; CADHERIN GENE PROMOTER; SYNTHASE
   MESSENGER-RNA; DIABETIC-NEPHROPATHY; METABOLIC SYNDROME; OXIDATIVE
   STRESS; SODIUM-TRANSPORT; NO GENERATION; RAT-KIDNEY; HYPERTENSION
AB Li L, Garikepati RM, Tsukerman S, Tiwari S, Ecelbarger CM. Salt sensitivity of nitric oxide generation and blood pressure in mice with targeted knockout of the insulin receptor from the renal tubule. Am J Physiol Regul Integr Comp Physiol 303: R505-R512, 2012. First published July 18, 2012; doi:10.1152/ajpregu.00033.2012.-To elucidate the role of the insulin receptor (IR) on kidney nitric oxide generation and blood pressure (BP) control, we generated mice with targeted deletion of renal tubule IR using loxP recombination driven by a Ksp-cadherin promoter. Male knockout (KO) and wild-type (WT) littermates (similar to 4 mo old) were transitioned through three 1-wk treatments: 1) low-NaCl diet (0.085%); 2) high-NaCl diet (HS; 5%); and 3) HS diet plus 3 mM tempol, a superoxide dismutase mimetic, in the drinking water. Mice were then switched to medium-NaCl (0.5%) diet for 5 days and kidneys harvested under pentobarbital anesthesia. Twenty-four-hour urinary nitrates plus nitrites were significantly higher in the WT mice under HS (2,067 +/- 280 vs. 1,550 +/- 230 nmol/day in WT and KO, respectively, P < 0.05). Tempol attenuated genotype differences in urinary nitrates plus nitrites. A rise in BP with HS was observed only in KO mice and not affected by tempol (mean arterial pressure, dark period, HS, 106 +/- 5 vs. 119 +/- 4 mmHg, for WT and KO, respectively, P < 0.05). Renal outer medullary protein levels of nitric oxide synthase (NOS) isoforms by Western blot (NOS1-3 and phosphorylated-S1177-NOS3) revealed significantly lower band density for NOS1 (130-kDa isoform) in the KO mice. A second study, when mice were euthanized under HS conditions, confirmed significantly lower NOS1 (130 kDa) in the KO, with an even more substantial (>50%) reduction of the 160-kDa NOS1 isoform. These studies suggest that the loss of renal IR signaling impairs renal nitric oxide production. This may be important in BP control, especially in insulin-resistant states, such as the metabolic syndrome.
C1 [Li, Lijun; Garikepati, R. Mayuri; Tsukerman, Susanna; Tiwari, S.; Ecelbarger, Carolyn M.] Georgetown Univ, Dept Med, Washington, DC 20007 USA.
   [Tiwari, S.] Sanjay Gandhi Postgrad Inst Med Sci, Dept Mol Med & Biotechnol, Lucknow, Uttar Pradesh, India.
C3 Georgetown University; Sanjay Gandhi Postgraduate Institute of Medical
   Sciences
RP Ecelbarger, CM (corresponding author), Georgetown Univ, Dept Med, 4000 Reservoir Rd NW, Washington, DC 20007 USA.
EM ecelbarc@georgetown.edu
FU National Institute of Diabetes and Digestive and Kidney Diseases Grant
   [DK082507]; American Heart Association Established Investigator Award;
   DBT-Ramalingaswami grant
FX This work was primarily supported by National Institute of Diabetes and
   Digestive and Kidney Diseases Grant DK082507 (to C. M. Ecelbarger), as
   well as the American Heart Association Established Investigator Award
   (to C. M. Ecelbarger). S. Tiwari is partially supported by a
   DBT-Ramalingaswami grant.
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NR 58
TC 13
Z9 13
U1 0
U2 7
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0363-6119
EI 1522-1490
J9 AM J PHYSIOL-REG I
JI Am. J. Physiol.-Regul. Integr. Comp. Physiol.
PD SEP
PY 2012
VL 303
IS 5
BP R505
EP R512
DI 10.1152/ajpregu.00033.2012
PG 8
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA 001LL
UT WOS:000308462100006
PM 22814664
OA Green Published
DA 2025-06-11
ER

PT J
AU Lee, H
   Na, W
   Lee, SB
   Ahn, CW
   Moon, JS
   Won, KC
   Shin, S
AF Lee, Hoyoon
   Na, Wonwhi
   Lee, Sang Bae
   Ahn, Chul Woo
   Moon, Jun Sung
   Won, Kyu Chang
   Shin, Sehyun
TI Potential Diagnostic Hemorheological Indexes for Chronic Kidney Disease
   in Patients With Type 2 Diabetes
SO FRONTIERS IN PHYSIOLOGY
LA English
DT Review
DE diabetic nephropathy; chronic kidney disease; deformability; critical
   shear stress; diagnosis
ID BLOOD-CELL DEFORMABILITY; ERYTHROCYTE-MEMBRANE FLUIDITY; THRESHOLD
   SHEAR-STRESS; RBC AGGREGATION; MICROFLUIDIC APPROACH; METABOLIC
   SYNDROME; ELONGATION INDEX; ANALYZER LORCA; FIBRINOGEN; ASSOCIATION
AB Many studies have demonstrated that an alteration in hemorheological properties is closely correlated with diabetic microcirculatory diseases. However, most of these studies have been limited to animal studies or used a small number of clinical samples, due to a lack of effective point-of-care (POC) devices to measure such properties within clinical environments. Owing to recent developments in microfluidic technology, several hemorheological POC devices have been designed that allow for the possibility of conducting extensive clinical studies using hemorheological measurements. Here, we reviewed recent clinical studies of diabetic kidney disease (DKD) associated with hemorheological parameters. We found that RBC deformability alone did not show a significant difference according to the degree of DKD, whereas critical shear stress (CSS) was found to be closely related to the ratio of albumin to creatinine and glomerular filtration rate. We also reviewed studies that alteration of hemorheological properties are associated with the development of DKD, which showed that CSS could be considered as a potential index to diagnose other diabetic complications as well as DKD.
C1 [Lee, Hoyoon; Na, Wonwhi; Shin, Sehyun] Korea Univ, Sch Mech Engn, Seoul, South Korea.
   [Lee, Sang Bae; Ahn, Chul Woo] Yonsei Univ, Coll Med, Dept Internal Med, Seoul, South Korea.
   [Moon, Jun Sung; Won, Kyu Chang] Yeungnam Coll Med, Dept Internal Med, Div Endocrinol & Metab, Daegu, South Korea.
C3 Korea University; Yonsei University; Yonsei University Health System
RP Shin, S (corresponding author), Korea Univ, Sch Mech Engn, Seoul, South Korea.
EM lexerdshin@korea.ac.kr
RI Shin, Sehyun/C-3128-2011
OI Shin, Sehyun/0000-0002-2611-5610; Won, Kyu Chang/0000-0001-5945-3395
FU National Research Foundation of Korea Grant - Korean Government
   [2015K2A1B8068546]; Korean Health Technology R&D Project, Ministry of
   Health and Welfare [HI14C0670]
FX This research was supported by a National Research Foundation of Korea
   Grant funded by the Korean Government (2015K2A1B8068546), and the Korean
   Health Technology R&D Project, Ministry of Health and Welfare (No.
   HI14C0670).
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NR 97
TC 19
Z9 20
U1 0
U2 4
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-042X
J9 FRONT PHYSIOL
JI Front. Physiol.
PD AUG 20
PY 2019
VL 10
AR 1062
DI 10.3389/fphys.2019.01062
PG 12
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA IR9VL
UT WOS:000481794500001
PM 31481899
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Huo, YJ
   Wu, XQ
   Ding, J
   Geng, Y
   Qiao, WW
   Ge, AY
   Guo, C
   Lv, JN
   Bao, HF
   Fan, W
AF Huo, Yajing
   Wu, Xuqing
   Ding, Jing
   Geng, Yang
   Qiao, Weiwei
   Ge, Anyan
   Guo, Cen
   Lv, Jianing
   Bao, Haifeng
   Fan, Wei
TI Vascular Remodeling, Oxidative Stress, and Disrupted PPARγ Expression in
   Rats of Long-Term Hyperhomocysteinemia with Metabolic Disturbance
SO PPAR RESEARCH
LA English
DT Article
ID PLASMA HOMOCYSTEINE LEVELS; INSULIN-RESISTANCE; ATHEROSCLEROSIS;
   HYPERTENSION; METHIONINE; RECEPTOR; STROKE; INJURY; HEART; DIET
AB Hyperhomocysteinemia, a risk factor for vascular disease, is associated with metabolic syndrome. Our study was aimed at exploring the effect of long-term hyperhomocysteinemia with metabolic disturbances on vascular remodeling. We also studied oxidative stress and expression of PPAR gamma in the coronary arteriole as a possible mechanism underlying vascular remodeling. Rats were treated with standard rodent chow (Control) or diet enriched in methionine (Met) for 48 weeks. Plasma homocysteine, blood glucose, serum lipids, malondialdehyde (MDA), superoxide dismutase (SOD), and nitric oxide (NO) levels were measured. Coronary arteriolar and carotid arterial remodeling was assessed by histomorphometric techniques and the expression of PPAR gamma in vessel wall was investigated. In Met group, an increase in the level of fasting blood glucose, serum triglyceride, total cholesterol, MDA, and NO, a decline in the serum SOD level, and increased collagen deposition in coronary and carotid arteries were found. Moreover, we detected decreased expression of PPAR gamma in the coronary arterioles in Met group. In summary, our study revealed metabolic disturbances in this model of long-term hyperhomocysteinemia together with vascular remodeling and suggested that impaired oxidative stress, endothelium dysfunction, and decreased PPAR gamma expression in the vessel wall could be underlying mechanisms.
C1 [Huo, Yajing; Wu, Xuqing; Ding, Jing; Geng, Yang; Ge, Anyan; Guo, Cen; Lv, Jianing; Bao, Haifeng; Fan, Wei] Fudan Univ, Zhongshan Hosp, Dept Neurol, Shanghai 200032, Peoples R China.
   [Qiao, Weiwei] Fudan Univ, Dept Lab Anim Sci, Shanghai 200032, Peoples R China.
C3 Fudan University; Fudan University
RP Fan, W (corresponding author), Fudan Univ, Zhongshan Hosp, Dept Neurol, Shanghai 200032, Peoples R China.
EM fan.wei@zs-hospital.sh.cn
RI Li, Tongyu/GQA-7514-2022
FU Shanghai Municipal Science and Technology Commission [12140903300]
FX This work was supported by the Shanghai Municipal Science and Technology
   Commission (Grant no. 12140903300).
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NR 42
TC 6
Z9 6
U1 0
U2 5
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1687-4757
EI 1687-4765
J9 PPAR RES
JI PPAR Res.
PY 2018
VL 2018
AR 6738703
DI 10.1155/2018/6738703
PG 9
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA FU2QE
UT WOS:000423694300001
PM 29552030
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Kumar, M
   Kaur, H
   Phondba, BT
   Mani, V
   Gupta, N
   Tyagi, AK
   Kushwaha, R
   Chandra, G
AF Kumar, Muneendra
   Kaur, Harjit
   Phondba, B. T.
   Mani, Veena
   Gupta, Neelam
   Tyagi, Amrish Kumar
   Kushwaha, Raju
   Chandra, Gulab
TI Effect of zinc treatments on cadmium exposed periparturient bovine
   lymphocytes in vitro on their proliferation and superoxide
   dismutase (SOD) expression
SO INDIAN JOURNAL OF ANIMAL SCIENCES
LA English
DT Article
DE Cadmium; Lymphocytes proliferation; mRNA expression; Superoxide
   dismutase; Zinc
ID OXIDATIVE STRESS; METABOLIC SYNDROME; PERIPHERAL-BLOOD; CYTO-TOXICITY;
   DNA-REPAIR; COWS; LEAD; MICE; TRANSFORMATION; PERFORMANCE
AB This study was conducted to evaluate effect of cadmium (Cd) on lymphocyte proliferation and mRNA expression of Cu/Zn superoxide dismutase (SOD) and to determine whether zinc (Zn) treatment in Cd-exposed lymphocytes can modulate lymphocyte proliferation and SOD expression. Blood samples were collected from crossbred transition dairy cow at -30, -15, 0, 15 and 30 days of calving and evaluated for lymphocytes proliferation and SOD expression. Isolated lymphocytes were cultured with 10(-3), 10(-4), 10(-5) and 10(-6) molar (M) levels of Cd for 72 h. Adverse effect of transitional stress and Cd on lymphocyte proliferation and mRNA SOD expression was counteracted by 50, 55 and 60 micromolar (mu M) Zn. Mitogenic response of lymphocyte and mRNA expression of SOD reduced as the days of parturition advanced. Lymphocyte proliferation and mRNA SOD expression showed negative correlation with Cd levels. Treatment of Zn in the Cd-exposed lymphocyte culture improved lymphocyte proliferation and relative abundance of SOD mRNA expression. In summary, Zn can ameliorate adverse effect of transitional stress and Cd on lymphocyte proliferation and SOD expression in dairy cows.
C1 [Kumar, Muneendra; Kaur, Harjit; Phondba, B. T.; Mani, Veena; Gupta, Neelam; Tyagi, Amrish Kumar; Kushwaha, Raju; Chandra, Gulab] ICAR Natl Dairy Res Inst, Karnal 132001, Haryana, India.
   [Kumar, Muneendra; Kushwaha, Raju] DUVASU, Coll Vet Sci & Anim Husb, Dept Anim Nutr, Mathura, India.
   [Kaur, Harjit] ICAR Res Complex, KAB I, Agr Extens Div, New Delhi, India.
   [Phondba, B. T.] Natl Dairy Dev Board, Anand, Gujarat, India.
   [Mani, Veena; Tyagi, Amrish Kumar] Dairy Cattle Nutr Div, Karnal, Haryana, India.
   [Gupta, Neelam] Natl Bur Anim Genet Resources, Karnal, India.
   [Chandra, Gulab] SVBPUAT, Coll Vet & Anim Sci, Dept Vet Physiol & Biochem, Meerut, Uttar Pradesh, India.
C3 Indian Council of Agricultural Research (ICAR); ICAR - National Dairy
   Research Institute; U.P. Pandit Deen Dayal Upadhyaya Pashu Chikitsa
   Vigyan Vishwavidyalaya Evam Go; Indian Council of Agricultural Research
   (ICAR); ICAR - National Dairy Research Institute; Indian Council of
   Agricultural Research (ICAR); ICAR - National Bureau of Animal Genetic
   Resources; Sardar Vallabhbhai Patel University of Agriculture &
   Technology
RP Kumar, M (corresponding author), ICAR Natl Dairy Res Inst, Karnal 132001, Haryana, India.; Kumar, M (corresponding author), DUVASU, Coll Vet Sci & Anim Husb, Dept Anim Nutr, Mathura, India.
EM muneendra82@gmail.com; harjit1955@gmail.com; bhupendravet@gmail.com;
   Veenamani1@yahoo.com; neelamgnbagr@gmail.com; amrishtyagi1963@yahoo.com;
   rajuvet15@gmail.com; gulabdrvet@gmail.com
OI chandra, Gulab/0000-0001-8236-3830
FU Indian Council of Agricultural Research, New Delhi
FX The financial support for this study was provided by Indian Council of
   Agricultural Research, New Delhi. We would like to thank National Bureau
   of Animal Genetic Resources, Karnal, India for providing facilities for
   determination of superoxide dismutase expression.
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NR 40
TC 0
Z9 0
U1 0
U2 6
PU INDIAN COUNC AGRICULTURAL RES
PI NEW DELHI
PA KAB-1, NEW DELHI 110012, INDIA
SN 0367-8318
J9 INDIAN J ANIM SCI
JI Indian J. Anim. Sci.
PD DEC
PY 2016
VL 86
IS 12
BP 1385
EP 1390
PG 6
WC Agriculture, Dairy & Animal Science
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture
GA EF3MO
UT WOS:000390228700004
DA 2025-06-11
ER

PT J
AU Kim, H
   Bartley, GE
   Young, SA
   Seo, KH
   Yokoyama, W
AF Kim, Hyunsook
   Bartley, Glenn E.
   Young, Scott A.
   Seo, Kun-Ho
   Yokoyama, Wallace
TI Altered Hepatic Gene Expression Profiles Associated with Improved Fatty
   Liver, Insulin Resistance, and Intestinal Permeability after
   Hydroxypropyl Methylcellulose (HPMC) Supplementation in Diet-Induced
   Obese Mice
SO JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
LA English
DT Article
DE steatosis; lipid metabolism; insulin sensitivity; intestinal
   permeability; soluble dietary fiber
ID CORTICOSTEROID-BINDING GLOBULIN; NONALCOHOLIC STEATOHEPATITIS;
   GLUCOCORTICOID-RECEPTOR; BILE-ACID; METABOLIC SYNDROME; OXIDATIVE
   STRESS; LIPID-METABOLISM; ADIPOSE-TISSUE; FREE CORTISOL; WEIGHT-LOSS
AB The effect of hydroxypropyl methylcellulose (HPMC) on hepatic gene expression was analyzed by exon microarray and real-time PCR from livers of diet-induced obese (DIO) mice fed a high-fat (HF) diet supplemented with either 6% HPMC or 6% microcrystalline cellulose (MCC). HPMC-fed mice exhibited significantly reduced body weight gain (55% lower compared to MCC), liver weight (13%), plasma LDL-cholesterol concentration (45%), and HF diet-increased intestinal permeability (48%). HPMC significantly reduced areas under the curve for 2 h insulin and glucose responses, indicating enhanced insulin sensitivity and glucose metabolism. HPMC up-regulated hepatic genes related to fatty acid oxidation, cholesterol and bile acid synthesis, and cellular activation of glucocorticoid (bile acid recycling) and down-regulated genes related to oxidative stress, triglyceride synthesis, and polyunsaturated fatty acid elongation. In conclusion, HPMC consumption ameliorates the effects of a HF diet on intestinal permeability, insulin resistance, hepatic lipid accumulation, glucocorticoid-related bile acid recycling, oxidative stress, and weight gain in DIO mice.
C1 [Kim, Hyunsook] Univ Calif Davis, Dept Nutr, Davis, CA 95616 USA.
   [Kim, Hyunsook; Bartley, Glenn E.; Yokoyama, Wallace] ARS, Western Reg Res Ctr, USDA, Albany, CA USA.
   [Young, Scott A.] Dow Wolff Cellulos, Midland, MI USA.
   [Seo, Kun-Ho] Konkuk Univ, Coll Vet Med, Dept Publ Hlth, Seoul, South Korea.
C3 University of California System; University of California Davis; United
   States Department of Agriculture (USDA); Konkuk University
RP Kim, H (corresponding author), Univ Calif Davis, Dept Nutr, 1 Shields Ave, Davis, CA 95616 USA.
EM hyskim@ucdavis.edu
RI Kim, Hanjun/AAJ-7528-2021; Seo, Kun-Ho/AAQ-2666-2020
OI Kim, Hyunsook/0000-0001-7345-4167
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NR 52
TC 13
Z9 16
U1 0
U2 24
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0021-8561
EI 1520-5118
J9 J AGR FOOD CHEM
JI J. Agric. Food Chem.
PD JUL 3
PY 2013
VL 61
IS 26
BP 6404
EP 6411
DI 10.1021/jf400545w
PG 8
WC Agriculture, Multidisciplinary; Chemistry, Applied; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture; Chemistry; Food Science & Technology
GA 179SY
UT WOS:000321542800033
PM 23742138
DA 2025-06-11
ER

PT J
AU Piva, SJ
   Tatsch, E
   De Carvalho, JAM
   Bochi, GV
   Kober, H
   Duarte, T
   Duarte, MMMF
   da Cruz, IBM
   Moretto, MB
   Moresco, RN
AF Piva, Silvia Juliane
   Tatsch, Etiane
   Mainardi De Carvalho, Jose Antonio
   Bochi, Guilherme Vargas
   Kober, Helena
   Duarte, Thiago
   Medeiros Frescura Duarte, Marta Maria
   Manica da Cruz, Ivana Beatrice
   Moretto, Maria Beatriz
   Moresco, Rafael Noal
TI Assessment of Inflammatory and Oxidative Biomarkers in Obesity and Their
   Associations with Body Mass Index
SO INFLAMMATION
LA English
DT Article
DE inflammation; endothelial dysfunction; oxidative stress; obesity
ID ISCHEMIA-MODIFIED ALBUMIN; METABOLIC SYNDROME; CARDIOVASCULAR-DISEASE;
   INSULIN-RESISTANCE; DIABETES-MELLITUS; IMMUNE-SYSTEM; HEART-DISEASE;
   NITRIC-OXIDE; WEIGHT-LOSS; STRESS
AB The aim of this study was to evaluate the inflammatory and oxidative biomarkers' levels in obese subjects and their associations with body mass index (BMI), in order to investigate the role of these biomarkers in obesity. Fasting glucose, total cholesterol, HDL cholesterol, LDL cholesterol, triglycerides, apolipoprotein A, apolipoprotein B, albumin, urinary albumin, creatinine, glomerular filtration rate, interleukin-6 (IL-6), nitrate/nitrite (NOx), and ischemia-modified albumin (IMA) were measured in 93 subjects divided according to different BMI. IL-6, urinary albumin, and IMA levels were significantly higher in obese subjects. However, the levels of NOx were significantly lower in this population. Significant correlations between BMI and IL-6 (r = 0.326, P = 0.002), NOx (r = -0.249, P = 0.021), urinary albumin (r = 0.270, P = 0.008), and IMA (r = 0.286, P = 0.005) were reported. We have shown an increase of IL-6, urinary albumin, and IMA combined with lower levels of NOx in obese patients and an association between of these biomarkers with BMI, suggesting a possible interplay of oxidative stress, inflammation, and endothelial dysfunction state in obesity.
C1 [Piva, Silvia Juliane; Tatsch, Etiane; Mainardi De Carvalho, Jose Antonio; Bochi, Guilherme Vargas; Kober, Helena; Duarte, Thiago; Moresco, Rafael Noal] Univ Fed Santa Maria, Ctr Ciencias Saude, Lab Pesquisa Bioquim Clin, Dept Anal Clin & Toxicol, BR-97105900 Santa Maria, RS, Brazil.
   [Piva, Silvia Juliane; Tatsch, Etiane; Mainardi De Carvalho, Jose Antonio; Moretto, Maria Beatriz; Moresco, Rafael Noal] Univ Fed Santa Maria, Ctr Ciencias Saude, Programa Posgrad Ciencias Farmaceut, BR-97105900 Santa Maria, RS, Brazil.
   [Bochi, Guilherme Vargas; Kober, Helena; Manica da Cruz, Ivana Beatrice; Moretto, Maria Beatriz; Moresco, Rafael Noal] Univ Fed Santa Maria, Ctr Ciencias Saude, Programa Posgrad Farmacol, BR-97105900 Santa Maria, RS, Brazil.
   [Medeiros Frescura Duarte, Marta Maria] Univ Luterana Brasil, Dept Ciencias Saude, Santa Maria, RS, Brazil.
C3 Universidade Federal de Santa Maria (UFSM); Universidade Federal de
   Santa Maria (UFSM); Universidade Federal de Santa Maria (UFSM);
   Universidade Luterana do Brasil
RP Moresco, RN (corresponding author), Univ Fed Santa Maria, Ctr Ciencias Saude, Lab Pesquisa Bioquim Clin, Dept Anal Clin & Toxicol, Ave Roraima 1000,Predio 26,Sala 1401, BR-97105900 Santa Maria, RS, Brazil.
EM rnmoresco@yahoo.com.br
RI ; Antonio Mainardi de Carvalho, Jose/F-9418-2015; da Cruz; Manica da
   Cruz, Ivana/G-4329-2012; Moresco, Rafael/K-6118-2017
OI Bochi, Guilherme/0000-0003-1871-1356; Antonio Mainardi de Carvalho,
   Jose/0000-0001-8601-5630; da Cruz; Manica da Cruz,
   Ivana/0000-0003-3008-6899; Moresco, Rafael/0000-0003-3072-5080
FU CAPES; CNPq
FX E. Tatsch is a recipient of the CAPES Doctorate degree fellowship. G. V.
   Bochi is a recipient of the CAPES Master degree fellowship. R. N.
   Moresco, M. B. Moretto, and I. B. M. da Cruz are recipients of the CNPq
   research fellowship.
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NR 35
TC 43
Z9 46
U1 0
U2 8
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0360-3997
J9 INFLAMMATION
JI Inflammation
PD FEB
PY 2013
VL 36
IS 1
BP 226
EP 231
DI 10.1007/s10753-012-9538-2
PG 6
WC Cell Biology; Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Immunology
GA 076KB
UT WOS:000313954300025
PM 22961567
DA 2025-06-11
ER

PT J
AU Thomas, D
   Apovian, C
AF Thomas, Dylan
   Apovian, Caroline
TI Macrophage functions in lean and obese adipose tissue
SO METABOLISM-CLINICAL AND EXPERIMENTAL
LA English
DT Review
DE Macrophage; Adipose; Inflammation; Obesity; Fibrosis; Insulin
ID ACTIVATED PROTEIN-KINASE; ANTIGEN-PRESENTING CELLS; ACID-BINDING
   PROTEIN; DIET-INDUCED OBESITY; C-REACTIVE PROTEIN; FACTOR-KAPPA-B;
   INSULIN-RESISTANCE; T-CELLS; NLRP3 INFLAMMASOME; OXIDATIVE STRESS
AB Interactions between macrophages and adipocytes influence both metabolism and inflammation. Obesity-induced changes to macrophages and adipocytes lead to chronic inflammation and insulin resistance. This paper reviews the various functions of macrophages in lean and obese adipose tissue and how obesity alters adipose tissue macrophage phenotypes. Metabolic disease and insulin resistance shift the balance between numerous pro- and anti-inflammatory regulators of macrophages and create a feed-forward loop of increasing inflammatory macrophage activation and worsening adipocyte dysfunction. This ultimately leads to adipose tissue fibrosis and diabetes. The molecular mechanisms underlying these processes have therapeutic implications for obesity, metabolic syndrome, and diabetes. (C) 2017 Elsevier Inc. All rights reserved.
C1 [Thomas, Dylan] Boston Med Ctr, Sect Endocrinol Diabet Nutr & Weight Management, 88 East Newton St,H-3600, Boston, MA 02118 USA.
   [Apovian, Caroline] Boston Med Ctr, Sect Endocrinol Diabet Nutr & Weight Management, 88 East Newton St,Robinson 4400, Boston, MA 02118 USA.
C3 Boston Medical Center; Boston Medical Center
RP Apovian, C (corresponding author), Boston Med Ctr, Sect Endocrinol Diabet Nutr & Weight Management, 88 East Newton St,Robinson 4400, Boston, MA 02118 USA.
EM dylan.thomas@bmc.org; caroline.apovian@bmc.org
OI Apovian, Caroline/0000-0002-8029-1922; Thomas, Dylan/0000-0002-8838-2992
FU NIH [P30DK046200, R01 DK108056]
FX This work was supported by NIH P30DK046200 and R01 DK108056.
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NR 253
TC 216
Z9 242
U1 1
U2 46
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0026-0495
EI 1532-8600
J9 METABOLISM
JI Metab.-Clin. Exp.
PD JUL
PY 2017
VL 72
BP 120
EP 143
DI 10.1016/j.metabol.2017.04.005
PG 24
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA EY9KD
UT WOS:000404316600013
PM 28641779
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Sánchez-Alegría, K
   Arias, C
AF Sanchez-Alegria, Karina
   Arias, Clorinda
TI Functional consequences of brain exposure to saturated fatty acids: From
   energy metabolism and insulin resistance to neuronal damage
SO ENDOCRINOLOGY DIABETES & METABOLISM
LA English
DT Review
DE energy metabolism; insulin resistance; mitochondrial dysfunction;
   neurodegeneration; palmitic acid; saturated fatty acids
ID ENDOPLASMIC-RETICULUM STRESS; AMYLOID PRECURSOR PROTEIN; PANCREATIC
   BETA-CELLS; PALMITIC ACID; ALZHEIMERS-DISEASE; DOCOSAHEXAENOIC ACID;
   BIOLOGICAL MARKERS; LEPTIN RESISTANCE; OXIDATIVE STRESS;
   ARACHIDONIC-ACID
AB Introduction Saturated fatty acids (FAs) are the main component of high-fat diets (HFDs), and high consumption has been associated with the development of insulin resistance, endoplasmic reticulum stress and mitochondrial dysfunction in neuronal cells. In particular, the reduction in neuronal insulin signaling seems to underlie the development of cognitive impairments and has been considered a risk factor for Alzheimer's disease (AD). Methods This review summarized and critically analyzed the research that has impacted the field of saturated FA metabolism in neurons. Results We reviewed the mechanisms for free FA transport from the systemic circulation to the brain and how they impact neuronal metabolism. Finally, we focused on the molecular and the physiopathological consequences of brain exposure to the most abundant FA in the HFD, palmitic acid (PA). Conclusion Understanding the mechanisms that lead to metabolic alterations in neurons induced by saturated FAs could help to develop several strategies for the prevention and treatment of cognitive impairment associated with insulin resistance, metabolic syndrome, or type II diabetes.
C1 [Sanchez-Alegria, Karina; Arias, Clorinda] Univ Nacl Autonoma Mexico, Inst Invest Biomed, Dept Med Genom & Toxicol Ambiental, AP 70-228, Ciudad De Mexico 04510, Mexico.
C3 Universidad Nacional Autonoma de Mexico
RP Arias, C (corresponding author), Univ Nacl Autonoma Mexico, Inst Invest Biomed, Dept Med Genom & Toxicol Ambiental, AP 70-228, Ciudad De Mexico 04510, Mexico.
EM carias@unam.mx
OI Arias, Clorinda/0000-0002-5873-2904
FU Consejo Nacional de Ciencia y Tecnologia [A1-S-9559]
FX Consejo Nacional de Ciencia y Tecnologia, Grant/Award Number: A1-S-9559
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NR 174
TC 18
Z9 18
U1 2
U2 18
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
EI 2398-9238
J9 ENDOCRIN DIAB METAB
JI Endocrinol. Diabetes Metab.
PD JAN
PY 2023
VL 6
IS 1
DI 10.1002/edm2.386
EA NOV 2022
PG 12
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA 8A4TH
UT WOS:000877438000001
PM 36321333
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Nair, AR
   Pillai, AJ
   Nair, N
AF Nair, Anjana R.
   Pillai, Aiswarya J.
   Nair, Nandini
TI Cardiovascular Changes in Menopause
SO CURRENT CARDIOLOGY REVIEWS
LA English
DT Review
DE Dyslipidemia; endothelial dysfunction; oxidative stress; metabolic
   syndrome; menopause; cardiovascular aging
ID CORONARY HEART-DISEASE; VULVO-VAGINAL ATROPHY; RISK-FACTORS;
   GENITOURINARY SYNDROME; POSTMENOPAUSAL WOMEN; ENDOTHELIAL FUNCTION;
   HORMONE-THERAPY; REPLACEMENT THERAPY; CONJUGATED ESTROGEN; OXIDATIVE
   STRESS
AB Menopause is associated with changes consistent with cardiovascular aging. The effects of cardiac disease are multifaceted, affecting endothelial function, coronary artery physiology and metabolic dysfunction leading to structural changes in the coronary anatomy. A systematic review of literature from 1986 to 2019 was conducted using PubMed and Google Scholar. The search was directed to retrieve papers that addressed the changes in cardiovascular physiology in menopause and the current therapies available to treat cardiovascular manifestations of menopause. The metabolic and clinical factors secondary to menopause, such as dyslipidemia, insulin resistance, fat redistribution and systemic hypertension, contribute to the accelerated risk for cardiovascular aging and disease. Atherosclerosis appears to be the end result of the interaction between cardiovascular risk factors and their accentuation during the perimenopausal period. Additionally, complex interactions between oxidative stress and levels of L-arginine and ADMA may also influence endothelial dysfunction in menopause. The increased cardiovascular risk in menopause stems from the exaggerated effects of changing physiology on the cardiovascular system affecting peripheral, cardiac and cerebrovascular beds. The differential effects of menopause on cardiovascular disease at the subclinical, biochemical and molecular levels form the highlights of this review.
C1 [Nair, Anjana R.] TTUHSC, Dept Obstet & Gynecol, Transmt Campus, El Paso, TX 79911 USA.
   [Pillai, Aiswarya J.] Univ Texas El Paso, El Paso, TX 79968 USA.
   [Nair, Nandini] TTUHSC, Dept Internal Med, Div Cardiol, Lubbock, TX 79430 USA.
C3 Texas Tech University System; Texas Tech University Health Sciences
   Center Lubbock; University of Texas System; University of Texas El Paso;
   Texas Tech University System; Texas Tech University Health Sciences
   Center Lubbock
RP Nair, N (corresponding author), TTUHSC, Dept Med, Div Cardiol, Lubbock, TX 79430 USA.
EM Nandini.nair@gmail.com
OI nair, nandini/0000-0002-1243-4389; Pillai, Aiswarya/0000-0003-4929-6538
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NR 74
TC 50
Z9 54
U1 2
U2 26
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1573-403X
EI 1875-6557
J9 CURR CARDIOL REV
JI Curr. Cardiol. Rev.
PD JUL
PY 2021
VL 17
IS 4
AR e230421187681
DI 10.2174/1573403X16666201106141811
PG 8
WC Cardiac & Cardiovascular Systems
WE Emerging Sources Citation Index (ESCI)
SC Cardiovascular System & Cardiology
GA WE1QT
UT WOS:000705402900001
PM 33155924
DA 2025-06-11
ER

PT J
AU Shi, ZL
   Li, C
   Yin, Y
   Yang, Z
   Xue, H
   Mu, N
   Wang, YS
   Liu, ML
   Ma, H
AF Shi, Zhaoling
   Li, Chen
   Yin, Yue
   Yang, Zheng
   Xue, Han
   Mu, Nan
   Wang, Yishi
   Liu, Manling
   Ma, Heng
TI Aerobic Interval Training Regulated SIRT3 Attenuates
   High-Fat-Diet-Associated Cognitive Dysfunction
SO BIOMED RESEARCH INTERNATIONAL
LA English
DT Article
ID ALZHEIMERS-DISEASE; METABOLIC SYNDROME; OBESITY; EXERCISE; HIPPOCAMPUS;
   STRESS; MNSOD
AB Cognitive dysfunction is an important complicated disease in obesity. Exercise ameliorates obesity and the related cognitive dysfunction. However, the underlying mechanism is still unclear. In this study, we investigated whether aerobic interval training (AIT) could attenuate high-fat-diet- (HFD-) associated cognitive dysfunction and the possible mechanism of SIRT3-MnSOD pathway. C57BL/6 wild-type (WT) mice and SIRT3 knockout (KO) mice were randomized into control (Con) or HFD group with or without AIT training for 6 weeks. The spatial learning and memory ability were impaired in HFD group compared to the control group. The levels of mitochondrial protein acetylation were increased in the hippocampus of HFD group. The acetylation level of antioxidative MnSOD was increased as well. As a result, the ROS and MDA levels were significantly increased, which leads to the neuron apoptosis in the hippocampus. SIRT3 deficiency further aggravated HFD-induced cognitive dysfunction and susceptibility to oxidative stress injury. However, AIT upregulated neuron SIRT3 expression and decreased the acetylation of MnSOD. The hippocampus neuron oxidative stress and apoptosis were both decreased compared to untrained HFD group, which finally improved cognitive function of HFD mice. Collectively, AIT attenuates HFD- associated cognitive dysfunction through SIRT3 upregulation and improvement of antioxidative MnSOD activity.
C1 [Shi, Zhaoling] Fourth Mil Med Univ, Xijing Hosp, Dept Paediat, Xian, Shaanxi, Peoples R China.
   [Shi, Zhaoling; Li, Chen; Yin, Yue; Yang, Zheng; Xue, Han; Mu, Nan; Wang, Yishi; Liu, Manling; Ma, Heng] Fourth Mil Med Univ, Sch Basic Med, Dept Physiol & Pathophysiol, Xian, Shaanxi, Peoples R China.
C3 Air Force Medical University; Air Force Medical University
RP Liu, ML; Ma, H (corresponding author), Fourth Mil Med Univ, Sch Basic Med, Dept Physiol & Pathophysiol, Xian, Shaanxi, Peoples R China.
EM apple0210vip@163.com; hengma@fmmu.edu.cn
RI Wang, Yishi/IQU-0806-2023
OI Liu, Manling/0000-0002-3098-2880; Wang, Yishi/0009-0004-6021-0357
FU National Natural Science Foundation of China [31671424, 81322004];
   Science and Technology Research and Development Program of Shaanxi
   Province, China [2011KJXX66, 2015KW-050]
FX This work was supported by the following grants: National Natural
   Science Foundation of China, nos. 31671424 and 81322004 (to Dr. Ma); the
   Science and Technology Research and Development Program of Shaanxi
   Province, China, nos. 2011KJXX66 and 2015KW-050 (to Dr. Ma).
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NR 27
TC 25
Z9 25
U1 0
U2 9
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2314-6133
EI 2314-6141
J9 BIOMED RES INT
JI Biomed Res. Int.
PY 2018
VL 2018
AR 2708491
DI 10.1155/2018/2708491
PG 8
WC Biotechnology & Applied Microbiology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Research & Experimental Medicine
GA GA2LM
UT WOS:000428154200001
PM 29765980
OA Green Published, Green Submitted, hybrid
DA 2025-06-11
ER

PT J
AU Luca, VS
   Miron, A
   Aprotosoaie, AC
AF Luca, Vlad Simon
   Miron, Anca
   Aprotosoaie, Ana Clara
TI The antigenotoxic potential of dietary flavonoids
SO PHYTOCHEMISTRY REVIEWS
LA English
DT Article; Proceedings Paper
CT 2nd International Conference on Natural Products Utilization - From
   Plants to Pharmacy Shelf
CY OCT 14-17, 2015
CL Plovdiv, BULGARIA
SP Phytochem Soc Europe
DE Genotoxic damage; Oxidative stress; Quercetin; Epigallocatechin gallate;
   Cyanidin
ID INDUCED DNA-DAMAGE; INDUCED OXIDATIVE STRESS; NITROSODIETHYLAMINE
   (NDEA)-INDUCED HEPATOTOXICITY; INDUCED GENOTOXIC DAMAGE; SINGLE-STRAND
   BREAKS; BONE-MARROW-CELLS; IN-VITRO; HUMAN-LYMPHOCYTES; HEPG2 CELLS;
   (-)-EPIGALLOCATECHIN-3-GALLATE EGCG
AB Human exposure to genotoxic agents has dramatically increased. Both endogenous (reactive species generated during physiological and pathological processes) and exogenous (UV light, ionizing radiation, alkylating agents, antimetabolites and topoisomerase inhibitors, air, water and food pollutants) factors can impair genomic stability. The cumulative DNA damage causes mutations involved in the development of cancer and other disorders (neuromuscular and neurodegenerative diseases, immune deficiencies, infertility, cardiovascular diseases, metabolic syndrome and aging). Dietary flavonoids have protective effects against DNA damage induced by different genotoxic agents such as mycotoxins, food processing-derived contaminants (polycyclic aromatic hydrocarbons, N-nitrosamines), cytostatic agents, other medications (estrogenic and androgenic hormones), nicotine, metal ions (Cd2+, Cr6+), radiopharmaceuticals and ionizing radiation. Dietary flavonoids exert their genoprotection by reducing oxidative stress and modulation of enzymes responsible for bioactivation of genotoxic agents and detoxification of their reactive metabolites. Data on structure-activity relationship is sometimes contradictory. Free hydroxyl groups on the B ring (catechol moiety) and C-3 position of the C ring are important structural features for the antigenotoxic activity. As dietary flavonoids are extensively metabolized, more in vivo studies are needed for a better characterization of their antigenotoxic potential.
C1 [Luca, Vlad Simon; Miron, Anca; Aprotosoaie, Ana Clara] Univ Med & Pharm Grigore T Popa Iasi, Fac Pharm, Dept Pharmacognosy, Univ Str 16, Iasi 700115, Romania.
C3 Grigore T Popa University of Medicine & Pharmacy
RP Miron, A (corresponding author), Univ Med & Pharm Grigore T Popa Iasi, Fac Pharm, Dept Pharmacognosy, Univ Str 16, Iasi 700115, Romania.
EM ancamiron@yahoo.com
RI Aprotosoaie, AnaClara/MTF-8715-2025; Luca, Simon/AAF-2613-2019; Miron,
   Anca/H-4572-2016
OI Luca, Simon Vlad/0000-0003-0904-0060; Miron, Anca/0000-0001-6078-2524
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NR 140
TC 32
Z9 33
U1 0
U2 50
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1568-7767
EI 1572-980X
J9 PHYTOCHEM REV
JI Phytochem. Rev.
PD AUG
PY 2016
VL 15
IS 4
SI SI
BP 591
EP 625
DI 10.1007/s11101-016-9457-1
PG 35
WC Plant Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Plant Sciences
GA DR0TD
UT WOS:000379618900005
DA 2025-06-11
ER

PT J
AU Su, HM
   Feng, LN
   Zheng, XD
   Chen, W
AF Su, Hong-ming
   Feng, Li-na
   Zheng, Xiao-dong
   Chen, Wei
TI Myricetin protects against diet-induced obesity and ameliorates
   oxidative stress in C57BL/6 mice
SO JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
LA English
DT Article
DE Myricetin; Obesity; Adipogenesis; Oxidative stress
ID CHINESE BAYBERRY EXTRACT; MEDIATED DNA-DAMAGE; HIGH-FAT; ADIPOSE-TISSUE;
   TNF-ALPHA; INSULIN-RESISTANCE; METABOLIC SYNDROME; DIABETIC-RATS;
   SUPPLEMENTATION; INHIBITION
AB Myricetin is a naturally occurring antioxidant commonly found in various plants. However, little information is available with respect to its direct anti-obesity effects.
   This study was undertaken to investigate the effect of myricetin on high-fat diet (HFD)-induced obesity in C57BL/6 mice.
   Administration of myricetin dramatically reduced the body weight of diet-induced obese mice compared with solely HFD-induced mice. Several parameters related to obesity including serum glucose, triglyceride, and cholesterol were significantly decreased in myricetin-treated mice. Moreover, obesity-associated oxidative stress (glutathione peroxidase (GPX) activity, total antioxidant capacity (T-AOC), and malondialdehyde (MDA)) and inflammation (tumor necrosis factor-alpha (TNF-alpha)) were ameliorated in myricetin-treated mice. Further investigation revealed that the protective effect of myricetin against HFD-induced obesity in mice appeared to be partially mediated through the down-regulation of mRNA expression of adipogenic transcription factors peroxisome proliferator-activated receptor gamma (PPAR gamma) and CCAAT/enhancer-binding protein alpha (C/EBP alpha), and lipogenic transcription factor sterol regulatory element-binding protein 1c (SREBP-1c).
   Consumption of myricetin may help to prevent obesity and obesity-related metabolic complications.
C1 [Su, Hong-ming; Zheng, Xiao-dong; Chen, Wei] Zhejiang Univ, Zhejiang Key Lab Agrofood Proc, Dept Food Sci & Nutr, Hangzhou 310058, Zhejiang, Peoples R China.
   [Feng, Li-na] Zhejiang Gongshang Univ, Coll Food Sci & Biotechnol, Hangzhou 310035, Zhejiang, Peoples R China.
C3 Zhejiang University; Zhejiang Gongshang University
RP Chen, W (corresponding author), Zhejiang Univ, Zhejiang Key Lab Agrofood Proc, Dept Food Sci & Nutr, Hangzhou 310058, Zhejiang, Peoples R China.
EM zjuchenwei@zju.edu.cn
RI Chen, Wei/AAR-9817-2020; Su, Hongming/M-9431-2013; zheng,
   xiaodong/C-4050-2008
OI CHEN, WEI/0000-0002-2373-2437; Su, Hongming/0000-0002-9847-1825
FU Scientific Research Foundation of the Education Department of Zhejiang
   Province [Y201328143]; Food Science and Engineering the Most Important
   Discipline of Zhejiang Province [JYTSP20142012]; National Key Technology
   R & D Program of China [2012BAD33B08]; Foundation of Fuli Institute of
   Food Science, Zhejiang University, China
FX Project supported by the Scientific Research Foundation of the Education
   Department of Zhejiang Province (No. Y201328143), the Food Science and
   Engineering the Most Important Discipline of Zhejiang Province (No.
   JYTSP20142012), the National Key Technology R & D Program of China (No.
   2012BAD33B08), and the Foundation of Fuli Institute of Food Science,
   Zhejiang University (2013), China
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NR 45
TC 56
Z9 61
U1 2
U2 53
PU ZHEJIANG UNIV
PI HANGZHOU
PA EDITORIAL BOARD, 20 YUGU RD, HANGZHOU, 310027, PEOPLES R CHINA
SN 1673-1581
EI 1862-1783
J9 J ZHEJIANG UNIV-SC B
JI J. Zhejiang Univ.-SCI. B
PD JUN
PY 2016
VL 17
IS 6
BP 437
EP 446
DI 10.1631/jzus.B1600074
PG 10
WC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
   Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
   Research & Experimental Medicine
GA DO0KH
UT WOS:000377467300003
PM 27256677
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Hou, XG
   Song, J
   Li, XN
   Zhang, L
   Wang, XL
   Chen, L
   Shen, YH
AF Hou, Xinguo
   Song, Jun
   Li, Xiao-Nan
   Zhang, Lin
   Wang, XingLi
   Chen, Li
   Shen, Ying H.
TI Metformin reduces intracellular reactive oxygen species levels by
   upregulating expression of the antioxidant thioredoxin via the
   AMPK-FOXO3 pathway
SO BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
LA English
DT Article
DE Metformin; AMP-activated protein kinase; Forkhead transcription factor
   3; Thioredoxin; Reactive oxygen species
ID ACTIVATED PROTEIN-KINASE; SMOOTH-MUSCLE-CELLS; ENDOTHELIAL-CELLS;
   OXIDATIVE STRESS; P38 MAPK; HYPERGLYCEMIA; FOXO; SUPPRESSION;
   SENSITIVITY; MODULATION
AB Background: Oxidative stress induced by free fatty acids plays a critical role in the pathogenesis of endothelial dysfunction and atherosclerosis in patients with metabolic syndrome. Reducing oxidative stress in these patients may prevent cardiovascular complications. The antidiabetic agent metformin has been reported to directly protect the cardiovascular system. In this study, we examined the effect of metformin on the intracellular levels of reactive oxygen species (ROS) induced by palmitic acid (PA) in human aortic endothelial cells and studied the molecular mechanisms involved. Methods and results: We observed that metformin significantly reduced intracellular ROS levels induced by PA. Additionally, metformin increased the expression of the antioxidant thioredoxin (Trx), which mediated metformin's effects on ROS reduction. Metformin increased Trx expression through the AMP-activated protein kinase (AMPK) pathway. Metformin-regulated Trx at the transcriptional level and forkhead transcription factor 3 (FOXO3) was involved in this process. Conclusion: These results suggest that metformin reduces ROS levels by inducing Trx expression through activation of the AMPK-FOXO3 pathway. (C) 2010 Elsevier Inc. All rights reserved.
C1 [Hou, Xinguo; Song, Jun; Li, Xiao-Nan; Zhang, Lin; Wang, XingLi; Chen, Li; Shen, Ying H.] Texas Heart Inst, Houston, TX 77030 USA.
   [Hou, Xinguo; Song, Jun; Li, Xiao-Nan; Chen, Li] Shandong Univ, Qilu Hosp, Jinan 250100, Shandong, Peoples R China.
   [Hou, Xinguo; Song, Jun; Li, Xiao-Nan; Zhang, Lin; Wang, XingLi; Shen, Ying H.] Baylor Coll Med, Div Cardiothorac Surg, Michael E DeBakey Dept Surg, Houston, TX 77030 USA.
C3 Texas Heart Institute; Shandong University; Baylor College of Medicine
RP Chen, L (corresponding author), Texas Heart Inst, C-1095,6770 Bertner Ave, Houston, TX 77030 USA.
EM hyshen@bcm.edu
RI wang, xingli/MHR-1399-2025; shen, ying/HHS-5635-2022; hou,
   xinguo/KHT-6105-2024
OI hou, xinguo/0000-0003-2045-1290
FU  [AHA-TX 0565134Y];  [AHA-0730190N]
FX This study was supported by grants AHA-TX 0565134Y (Y.H.S.) and
   AHA-0730190N (Y.H.S.).
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U1 0
U2 24
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0006-291X
EI 1090-2104
J9 BIOCHEM BIOPH RES CO
JI Biochem. Biophys. Res. Commun.
PD MAY 28
PY 2010
VL 396
IS 2
BP 199
EP 205
DI 10.1016/j.bbrc.2010.04.017
PG 7
WC Biochemistry & Molecular Biology; Biophysics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics
GA 609LL
UT WOS:000278658000005
PM 20398632
DA 2025-06-11
ER

PT J
AU Mancini, A
   Leone, E
   Festa, R
   Grande, G
   Silvestrini, A
   De Marinis, L
   Pontecorvi, A
   Maira, G
   Littarru, GP
   Meucci, E
AF Mancini, Antonio
   Leone, Erika
   Festa, Roberto
   Grande, Giuseppe
   Silvestrini, Andrea
   De Marinis, Laura
   Pontecorvi, Alfredo
   Maira, Giulio
   Littarru, Gian Paolo
   Meucci, Elisabetta
TI Effects of Testosterone on Antioxidant Systems in Male Secondary
   Hypogonadism
SO JOURNAL OF ANDROLOGY
LA English
DT Article
DE Androgen; oxidative stress; coenzyme Q(10); total antioxidant capacity
ID COENZYME Q(10); PLASMA; ANDROGENS; CAPACITY; MEN; METABOLISM; DISEASE;
   ATHEROSCLEROSIS; CALCIUM; INSULIN
AB Oxidative stress is involved both in metabolic syndrome and male infertility. Hypogonadism is also associated with increased risk for cardiovascular disease. To investigate the role of gonadal steroids in systemic antioxidant regulation, we determined plasma CoenzymeQ(10) (CoQ(10)) and total antioxidant capacity (TAC) in postsurgical hypopituitaric patients. Twenty-six patients aged 28-55 years were studied 6-12 months after surgery. CoQ(10) levels were measured by high-performance liquid chromatography and TAC by spectroscopy with the use of the mioglobin-H2O2 system, which, in interacting with chromogen 2,2(I)-azinobis-(3-ethylbenzothiazoline-6-sulfonate), generates a radical after a latency time (LAG) that is proportional to antioxidant content. Sixteen patients presented low testosterone values; in 10 patients hypogonadism was isolated, and in 6 patients hypothyroidism also was present. CoQ(10) levels were significantly lower in isolated hypogonadism than in normogonadism. Testosterone treatment, performed in those patients with isolated hypogonadism, induced a significant enhancement both in CoQ(10) level and LAG. CoQ(10) and LAG values correlated significantly, suggesting an interrelationship between different antioxidants. Our data suggest that hypogonadism could represent a condition of oxidative stress, in turn related with augmented cardiovascular risk.
C1 [Mancini, Antonio; Leone, Erika; Festa, Roberto; Grande, Giuseppe; De Marinis, Laura; Pontecorvi, Alfredo] Univ Cattolica Sacro Cuore, Chair Endocrinol, I-00168 Rome, Italy.
   [Silvestrini, Andrea; Meucci, Elisabetta] Univ Cattolica Sacro Cuore, Inst Biochem & Clin Biochem, I-00168 Rome, Italy.
   [Maira, Giulio] Univ Cattolica Sacro Cuore, Inst Neurosurg, I-00168 Rome, Italy.
   [Littarru, Gian Paolo] Univ Politecn Marche, Inst Biochem, Ancona, Italy.
C3 Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli;
   Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli;
   Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli;
   Marche Polytechnic University
RP Mancini, A (corresponding author), Largo G Vidari 7, I-00135 Rome, Italy.
EM mancini.giac@mclink.it
RI Pontecorvi, Alfredo/K-5146-2016; Grande, Giuseppe/AAC-2813-2019;
   Silvestrini, Andrea/B-3410-2009
OI MEUCCI, Elisabetta/0000-0002-8821-8041; Silvestrini,
   Andrea/0000-0002-2005-3746; PONTECORVI, Alfredo/0000-0003-0570-6865;
   Grande, Giuseppe/0000-0003-3264-0937
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NR 56
TC 61
Z9 65
U1 0
U2 10
PU AMER SOC ANDROLOGY, INC
PI LAWRENCE
PA C/O ALLEN PRESS, INC PO BOX 368, LAWRENCE, KS 66044 USA
SN 0196-3635
EI 1939-4640
J9 J ANDROL
JI J. Androl.
PD NOV-DEC
PY 2008
VL 29
IS 6
BP 622
EP 629
DI 10.2164/jandrol.107.004838
PG 8
WC Andrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 365IN
UT WOS:000260399300005
PM 18641414
OA Bronze
DA 2025-06-11
ER

PT J
AU Han, C
   Rice, MW
   Cai, DS
AF Han, Cheng
   Rice, Matthew W.
   Cai, Dongsheng
TI Neuroinflammatory and autonomic mechanisms in diabetes and hypertension
SO AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
LA English
DT Review
DE autonomic nervous system; hypothalamus; inflammation
ID SYMPATHETIC-NERVOUS-SYSTEM; RENIN-ANGIOTENSIN SYSTEM;
   BLOOD-BRAIN-BARRIER; GROWTH-FACTOR-BETA; NF-KAPPA-B; HYPOTHALAMIC
   PARAVENTRICULAR NUCLEUS; ROSTRAL VENTROLATERAL MEDULLA;
   ENDOPLASMIC-RETICULUM STRESS; DIET-INDUCED THERMOGENESIS; BODY-WEIGHT
   REGULATION
AB Interdisciplinary studies in the research fields of endocrinology and immunology show that obesity-associated overnutrition leads to neuroinflammatory molecular changes, in particular in the hypothalamus, chronically causing various disorders known as elements of metabolic syndrome. In this process, neural or hypothalamic inflammation impairs the neuroendocrine and autonomic regulation of the brain over blood pressure and glucose homeostasis as well as insulin secretion, and elevated sympathetic activation has been appreciated as a critical mediator. This review describes the involved physiology and mechanisms, with a focus on glucose and blood pressure balance, and suggests that neuroinflammation employs the autonomic nervous system to mediate the development of diabetes and hypertension.
C1 [Han, Cheng; Rice, Matthew W.; Cai, Dongsheng] Albert Einstein Coll Med, Inst Aging, Dept Mol Pharmacol, Diabet Res Ctr, Bronx, NY 10461 USA.
C3 Montefiore Medical Center; Albert Einstein College of Medicine; Yeshiva
   University
RP Cai, DS (corresponding author), Albert Einstein Coll Med, Inst Aging, Dept Mol Pharmacol, Diabet Res Ctr, Bronx, NY 10461 USA.
EM dongsheng.cai@einstein.yu.edu
RI Cai, Dongsheng/CAH-8271-2022
OI Rice, Matthew/0000-0002-8160-3297
FU National Institutes of Health [R01-DK-078750, R01-AG-031774,
   R01-HL-113180, R01-DK-099136]
FX These projects were supported by National Institutes of Health Grants
   R01-DK-078750, R01-AG-031774, R01-HL-113180, and R01-DK-099136 (all
   awarded to D. Cai).
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NR 152
TC 39
Z9 45
U1 0
U2 22
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0193-1849
EI 1522-1555
J9 AM J PHYSIOL-ENDOC M
JI Am. J. Physiol.-Endocrinol. Metab.
PD JUL 1
PY 2016
VL 311
IS 1
BP E32
EP E41
DI 10.1152/ajpendo.00012.2016
PG 10
WC Endocrinology & Metabolism; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Physiology
GA DS1QS
UT WOS:000380372000002
PM 27166279
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Garcia-Moreno, H
   Calvo, JR
   Maldonado, MD
AF Garcia-Moreno, H.
   Calvo, J. R.
   Maldonado, M. D.
TI High levels of melatonin generated during the brewing process
SO JOURNAL OF PINEAL RESEARCH
LA English
DT Article
DE antioxidant; beer; brewer's yeast; hops; immunomodulation; malt;
   melatonin
ID OXIDATIVE STRESS; SACCHAROMYCES STRAINS; ANTIOXIDANT CAPACITY; METABOLIC
   SYNDROME; REACTIVE OXYGEN; EDIBLE PLANTS; IMMUNE-SYSTEM; INFLAMMATION;
   WATER; PHYTOREMEDIATION
AB Beer is a beverage consumed worldwide. It is produced from cereals (barley or wheat) and contains a wide array of bioactive phytochemicals and nutraceutical compounds. Specifically, high melatonin concentrations have been found in beer. Beers with high alcohol content are those that present the greatest concentrations of melatonin and vice versa. In this study, gel filtration chromatography and ELISA were combined for melatonin determination. We brewed beer to determine, for the first time, the beer production steps in which melatonin appears. We conclude that the barley, which is malted and ground in the early process, and the yeast, during the second fermentation, are the largest contributors to the enrichment of the beer with melatonin.
C1 [Garcia-Moreno, H.; Calvo, J. R.; Maldonado, M. D.] Univ Seville, Sch Med, Dept Med Biochem Mol Biol & Immunol, E-41009 Seville, Spain.
C3 University of Sevilla
RP Maldonado, MD (corresponding author), Univ Seville, Sch Med, Dept Med Biochem Mol Biol & Immunol, Avda Sanchez Pizjuan 4, E-41009 Seville, Spain.
EM aibar@us.es
RI Maldonado y Aibar, Maria Dolores/A-3847-2008; Calvo, Juan R./A-7338-2017
OI Maldonado y Aibar, Maria Dolores/0000-0003-1375-447X; Calvo, Juan
   R./0000-0002-4854-2963
FU Seville University (Immunology area), Information centre beer and health
   (CICS); research group CTS-160 (Consejeria de Innovacion Ciencia y
   Empresa, Junta de Andalucia, Spain)
FX This work was supported by Seville University (Immunology area),
   Information centre beer and health (CICS) and research group CTS-160
   (Consejeria de Innovacion Ciencia y Empresa, Junta de Andalucia, Spain).
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NR 54
TC 51
Z9 52
U1 0
U2 48
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0742-3098
EI 1600-079X
J9 J PINEAL RES
JI J. Pineal Res.
PD AUG
PY 2013
VL 55
IS 1
BP 26
EP 30
DI 10.1111/jpi.12005
PG 5
WC Endocrinology & Metabolism; Neurosciences; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Physiology
GA 267YJ
UT WOS:000328134000004
PM 23607887
DA 2025-06-11
ER

PT J
AU Avignon, A
   Hokayem, M
   Bisbal, C
   Lambert, K
AF Avignon, Antoine
   Hokayem, Marie
   Bisbal, Catherine
   Lambert, Karen
TI Dietary antioxidants: Do they have a role to play in the ongoing fight
   against abnormal glucose metabolism?
SO NUTRITION
LA English
DT Review
DE Oxidative stress; Glucose metabolism; Insulin resistance; Antioxidants
ID POSTPRANDIAL OXIDATIVE STRESS; RANDOMIZED CONTROLLED-TRIAL; TYPE-2
   DIABETES-MELLITUS; INSULIN-RESISTANCE; MITOCHONDRIAL-FUNCTION;
   INFLAMMATORY MARKERS; SKELETAL-MUSCLE; TEA CONSUMPTION; BETA-CAROTENE;
   CAFFEIC ACID
AB Overfeeding, an increased intake of saturated fatty acids, and sugary food; are key dietary changes that have occurred in recent decades in addition to the emergence of the obesity epidemic. In addition to an increase in energy storage as fat, these dietary changes are accompanied by an increase in mitochondrial macronutrient oxidation, leading to an excessive free radical production and, hence, oxidative stress. The latter has long been considered a central mechanism linking nutrient overload, insulin resistance, the metabolic syndrome, and diabetes. However, food, through fruit and vegetable consumption, also can be a great source of antioxidants that protect the body against oxidative damage and insulin resistance and thus help cope with the metabolic backlash of the energy-dense Westernized diet. Experimental data are in favor of the beneficial role conveyed by antioxidants in glucose metabolism, but clinical data in humans remain controversial. This review therefore aimed to sort out any underlying discrepancies and provide an overall clear view of the role of antioxidants in the ongoing fight against abnormal glucose metabolism. (C) 2012 Elsevier Inc. All rights reserved.
C1 [Avignon, Antoine; Hokayem, Marie; Bisbal, Catherine; Lambert, Karen] INSERM, U1046, Montpellier, France.
   [Avignon, Antoine; Hokayem, Marie; Bisbal, Catherine; Lambert, Karen] Univ Montpellier 2, Univ Montpellier 1, Montpellier, France.
   [Avignon, Antoine] CHU Montpellier, Montpellier, France.
C3 Institut National de la Sante et de la Recherche Medicale (Inserm);
   Universite de Montpellier; Universite de Montpellier; Universite de
   Montpellier; CHU de Montpellier
RP Avignon, A (corresponding author), INSERM, U1046, Montpellier, France.
EM a-avignon@chu-montpellier.fr
RI Avignon, Antoine/AAD-5441-2020; Lambert, Karen/MJQ-7172-2025; Bisbal,
   Catherine/I-6984-2016
OI bisbal, catherine/0000-0003-1086-020X; Hokayem,
   Marie/0000-0001-7123-163X; Lambert, Karen/0000-0002-6389-2451
FU French National Research Agency
FX This work was supported by the French National Research Agency.
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NR 60
TC 63
Z9 67
U1 0
U2 28
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0899-9007
EI 1873-1244
J9 NUTRITION
JI Nutrition
PD JUL-AUG
PY 2012
VL 28
IS 7-8
BP 715
EP 721
DI 10.1016/j.nut.2012.01.001
PG 7
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 965LO
UT WOS:000305769500001
PM 22571840
OA Green Published
DA 2025-06-11
ER

PT J
AU Cain, MA
   Ricciuti, J
   Louis, JM
AF Cain, Mary Ashley
   Ricciuti, Jason
   Louis, Judette M.
TI Sleep-disordered breathing and future cardiovascular disease risk
SO SEMINARS IN PERINATOLOGY
LA English
DT Review
DE sleep disorderd breathing; preeclampsia; sleep apnea; obesity
ID POSITIVE AIRWAY PRESSURE; OXIDATIVE STRESS; APNEA SYNDROME; GESTATIONAL
   HYPERTENSION; VASCULAR ENDOTHELIUM; INSULIN-RESISTANCE; METABOLIC
   SYNDROME; DIABETES-MELLITUS; CONTROLLED-TRIAL; VITAMINS C
AB Sleep-disordered breathing occurs in 0.6-15% of reproductive age women. This condition is associated with an increased lifetime risk of cardiovascular disease, cardiovascular mortality, and all-cause mortality. A substantial body of evidence demonstrated increased perinatal morbidity among pregnancies affected by SDB including gestational diabetes, gestational hypertension, and preeclampsia. These same conditions are predictive of later cardiovascular disease. Treatment of SDB has been demonstrated to decrease future cardiovascular events and mortality. Screening at-risk individuals in the perinatal period can identify women with SDB, who can benefit from treatment. Continuous positive airway pressure and lifestyle interventions can decrease subsequent adverse cardiovascular health outcomes. (C) 2015 Elsevier Inc. All rights reserved.
C1 [Cain, Mary Ashley; Louis, Judette M.] Univ S Florida, Morsani Coll Med, Dept Obstet & Gynecol, Div Maternal Fetal Med, Tampa, FL 33609 USA.
   [Ricciuti, Jason] Univ Pittsburgh, Magee Womens Hosp, Med Ctr, Dept Obstet Gynecol & Reprod Sci, Pittsburgh, PA 15213 USA.
C3 State University System of Florida; University of South Florida;
   Pennsylvania Commonwealth System of Higher Education (PCSHE); University
   of Pittsburgh
RP Louis, JM (corresponding author), Univ S Florida, Morsani Coll Med, Dept Obstet & Gynecol, Div Maternal Fetal Med, 2 Tampa Gen Circle,Suite 6055, Tampa, FL 33609 USA.
EM jlouis1@health.usf.edu
RI Louis, Judette/E-5130-2013
OI Louis, Judette/0000-0002-1336-7886
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NR 59
TC 4
Z9 4
U1 0
U2 7
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0146-0005
EI 1558-075X
J9 SEMIN PERINATOL
JI Semin. Perinatol.
PD JUN
PY 2015
VL 39
IS 4
BP 304
EP 309
DI 10.1053/j.semperi.2015.05.010
PG 6
WC Obstetrics & Gynecology; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology; Pediatrics
GA CP4XD
UT WOS:000359885000010
PM 26143090
DA 2025-06-11
ER

PT J
AU Whalley, LJ
AF Whalley, LJ
TI Food supplement use and the prevention of cognitive decline in old
   people
SO AGRO FOOD INDUSTRY HI-TECH
LA English
DT Article
ID MENTAL SURVEY 1932; CHILDHOOD IQ; DIETARY-SUPPLEMENTS; METABOLIC
   SYNDROME; VITAMIN-C; AGE 11; ANTIOXIDANTS; ASSOCIATION; PERFORMANCE;
   HEALTH
AB Oxidative stress and low-grade inflammation stimulate the ageing brain to adapt to accumulated damage. Neuroprotection relies on intrinsic/extrinsic defences to which specific nutrients may contribute. Food intakes are often reinforced with supplements containing high concentrations of nutrients, in amounts that equal or exceed recommended daily allowances. This practice is often followed by those who have least need to reinforce their diets in this way. This brief review examines some psychosocial aspects of food supplement use in old age and examines the scant evidence of its efficacy In promoting the retention of cognitive function in old age. Presently, there is insufficient evidence that the use of food supplements should be recommended to prevent cognitive decline in old age.
C1 Royal Cornhill Hosp, Clin Res Ctr, Inst Appl Hlth Sci, Aberdeen AB25 2ZD, Scotland.
C3 University of Aberdeen
RP Royal Cornhill Hosp, Clin Res Ctr, Inst Appl Hlth Sci, Aberdeen AB25 2ZD, Scotland.
RI whalley, lawrence/E-9019-2011
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NR 38
TC 0
Z9 0
U1 0
U2 0
PU TEKNOSCIENZE PUBL
PI MILANO
PA VIALE BRIANZA 22, 20127 MILANO, ITALY
SN 1722-6996
EI 2035-4606
J9 AGRO FOOD IND HI TEC
JI Agro Food Ind. Hi-Tech
PD MAY-JUN
PY 2005
VL 16
IS 3
BP 19
EP 21
PG 3
WC Biotechnology & Applied Microbiology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Biotechnology & Applied Microbiology; Food Science & Technology
GA 953MD
UT WOS:000231079500016
DA 2025-06-11
ER

PT J
AU Wang, MX
   Li, BB
   Qin, FJ
   Ye, JM
   Jin, L
AF Wang, Mengxiao
   Li, Bingbing
   Qin, Fujian
   Ye, Junmei
   Jin, Liang
TI Obesity induced Ext1 reduction mediates the occurrence of NAFLD
SO BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
LA English
DT Article
DE NAFLD; Ext1; Insulin resistance; ER stress; Autophagy
ID FATTY LIVER-DISEASE
AB Non-alcoholic fatty liver disease (NAFLD) is the most common liver disorder with intricate etiology. It is closely associated with metabolic syndrome, insulin resistance and endoplasmic reticulum (ER) stress. Exostosin1 (Ext1) is an ER-resident transmembrane glycosyltransferase, which plays an important role in ER homeostasis. Loss-of-function mutations in Ext1 link to hereditary multiple exostosis (HME). The present research was undertaken to identify the effect of Ext1 in the progress of NAFLD. High-fat-diet induced mice obesity, hepatic steatosis and decreased hepatic Ext1 expression. In consistent with evaluation of NAFLD mice possessing down-regulated Ext1 expression, free fatty acid (FFA) treatment blunted Ext1 expression in hepatocytes. In human subjects, HME patients presented elevated fasting blood glucosedone of the criteria that define insulin resistance. In vitro experiments, Ext1 deficiency promoted FFA-induced insulin resistance in hepatocytes by analysis of glycogen storage and hallmarks of gluconeogenesis, ascertaining its association with insulin resistance. Mechanically, Ext1 silencing exacerbated ER stress triggered by FFA, which severely disrupted autophagy in hepatocytes, and thereby accelerated the progression of NAFLD. In conclusion, our study demonstrates a beneficial role for Ext1 during the development of NAFLD, which establishes a novel correlation between Ext1 and ER stressinduced perturbations of autophagy during NAFLD progression. (c) 2021 Published by Elsevier Inc.
C1 [Wang, Mengxiao; Li, Bingbing; Qin, Fujian; Ye, Junmei; Jin, Liang] China Pharmaceut Univ, Sch Life Sci & Technol, Nanjing 211198, Jiangsu, Peoples R China.
C3 China Pharmaceutical University
RP Ye, JM; Jin, L (corresponding author), China Pharmaceut Univ, Sch Life Sci & Technol, Nanjing 211198, Jiangsu, Peoples R China.
EM junmeiye@cpu.edu.cn; ljstemcell@cpu.edu.cn
RI liang, bingbing/HNI-0478-2023; Wang, Mengxiao/ABD-2144-2020
FU Natural Science Foundation of Jiangsu Province [BK20191324]
FX This work was supported by the Natural Science Foundation of Jiangsu
   Province (Grant No. BK20191324) .
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NR 25
TC 1
Z9 1
U1 0
U2 16
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0006-291X
EI 1090-2104
J9 BIOCHEM BIOPH RES CO
JI Biochem. Biophys. Res. Commun.
PD JAN 22
PY 2022
VL 589
BP 123
EP 130
DI 10.1016/j.bbrc.2021.12.017
EA DEC 2021
PG 8
WC Biochemistry & Molecular Biology; Biophysics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics
GA XT4MV
UT WOS:000733564600012
PM 34906902
DA 2025-06-11
ER

PT J
AU Binda, S
   Tremblay, A
   Iqbal, UH
   Kassem, O
   Le Barz, M
   Thomas, V
   Bronner, S
   Perrot, T
   Ismail, N
   Parker, JA
AF Binda, Sylvie
   Tremblay, Annie
   Iqbal, Umar Haris
   Kassem, Ola
   Le Barz, Melanie
   Thomas, Vincent
   Bronner, Stephane
   Perrot, Tara
   Ismail, Nafissa
   Parker, J. Alex
TI Psychobiotics and the Microbiota-Gut-Brain Axis: Where Do We Go from
   Here?
SO MICROORGANISMS
LA English
DT Review
DE psychobiotics; microbiota-gut-brain axis; stress; early-life stress;
   neuropsychiatric disorders; neuroinflammation; microglia; metabolic
   syndrome; obesity
ID MAJOR DEPRESSIVE DISORDER; PARKINSONS-DISEASE; IMMUNE ACTIVATION;
   DOUBLE-BLIND; STRESS; ALZHEIMERS; BACTERIA; HEALTH; NEUROINFLAMMATION;
   INTEROCEPTION
AB The bidirectional relationship between the gut microbiota and the nervous system is known as the microbiota-gut-brain axis (MGBA). The MGBA controls the complex interactions between the brain, the enteric nervous system, the gut-associated immune system, and the enteric neuroendocrine systems, regulating key physiological functions such as the immune response, sleep, emotions and mood, food intake, and intestinal functions. Psychobiotics are considered tools with the potential to modulate the MGBA through preventive, adjunctive, or curative approaches, but their specific mechanisms of action on many aspects of health are yet to be characterized. This narrative review and perspectives article highlights the key paradigms needing attention as the scope of potential probiotics applications in human health increases, with a growing body of evidence supporting their systemic beneficial effects. However, there are many limitations to overcome before establishing the extent to which we can incorporate probiotics in the management of neuropsychiatric disorders. Although this article uses the term probiotics in a general manner, it remains important to study probiotics at the strain level in most cases.
C1 [Binda, Sylvie; Le Barz, Melanie; Thomas, Vincent] Lallemand Hlth Solut, 19 Rue Briquetiers,BP 59, F-31702 Blagnac, France.
   [Binda, Sylvie; Tremblay, Annie; Iqbal, Umar Haris; Kassem, Ola; Bronner, Stephane] Lallemand Hlth Solut, Rosell Inst Microbiome & Probiot, 6100 Royalmount Ave, Montreal, PQ H4P 2R2, Canada.
   [Perrot, Tara] Dalhousie Univ, Dept Psychol & Neurosci, Halifax, NS B3H 4R2, Canada.
   [Ismail, Nafissa] Univ Ottawa, Dept Psychol, Ottawa, ON K1N 6N5, Canada.
   [Parker, J. Alex] Univ Montreal, Dept Neurosci, Montreal, PQ H3T 1J4, Canada.
C3 Lallemand - France; Dalhousie University; University of Ottawa;
   Universite de Montreal
RP Binda, S (corresponding author), Lallemand Hlth Solut, 19 Rue Briquetiers,BP 59, F-31702 Blagnac, France.; Binda, S (corresponding author), Lallemand Hlth Solut, Rosell Inst Microbiome & Probiot, 6100 Royalmount Ave, Montreal, PQ H4P 2R2, Canada.
EM sbinda@lallemand.com; atremblay@lallemand.com; iumarharis@lallemand.com;
   okassem@lallemand.com; mlebarz@lallemand.com; vthomas@lallemand.com;
   sbronner@lallemand.com; tara.perrot@dal.ca; nafissa.ismail@uottawa.ca;
   ja.parker@umontreal.ca
RI Thomas, Vincent/AAB-6394-2022; Thomas, Vincent/A-8941-2012
OI Thomas, Vincent/0000-0003-4034-9525; Ismail,
   Nafissa/0000-0002-0449-0217; Binda, sylvie/0009-0002-3939-4118
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NR 134
TC 11
Z9 12
U1 9
U2 18
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-2607
J9 MICROORGANISMS
JI Microorganisms
PD APR
PY 2024
VL 12
IS 4
AR 634
DI 10.3390/microorganisms12040634
PG 21
WC Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Microbiology
GA OX0P6
UT WOS:001210462600001
PM 38674579
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Vassalle, C
   Meloni, A
   Pistoia, L
   Gamberini, MR
   Spasiano, A
   Gerardi, C
   Zuccarelli, A
   Casini, T
   Righi, R
   Missere, M
   Positano, V
   Ndreu, R
   Pepe, A
AF Vassalle, Cristina
   Meloni, Antonella
   Pistoia, Laura
   Gamberini, Maria Rita
   Spasiano, Anna
   Gerardi, Calogera
   Zuccarelli, Angelo
   Casini, Tommaso
   Righi, Riccardo
   Missere, Massimiliano
   Positano, Vincenzo
   Ndreu, Rudina
   Pepe, Alessia
TI Relationship between uric acid levels and cardiometabolic findings in a
   large cohort of β-thalassemia major patients
SO BIOMARKERS IN MEDICINE
LA English
DT Article
DE iron overload; MIOT study; oxidative stress; thalassemia major; uric
   acid
ID TRANSFUSION-DEPENDENT THALASSEMIA; MYOCARDIAL IRON OVERLOAD; OXIDATIVE
   STRESS; MAGNETIC-RESONANCE; ANTIOXIDANT STATUS; METABOLIC SYNDROME;
   HEART; ASSOCIATION; DISEASE; DYSFUNCTION
AB Aim: to evaluate the relationship between uric acid (UA), hepatic and cardiac iron overload (T2*-MRI), ferritin, endocrinological diseases and cardiac complications in a large thalassemia major (TM) cohort. Methods: A total of 369 TM patients (187 men; 33 +/- 6 years) were retrospectively studied, from the myocardial iron overload in thalassemia (MIOT) electronic databank. Results: Multiple regression model identified male sex (p < 0.001), BMI (p < 0.001) and T2* (p <= 0.001) as UA independent correlates. Moreover, UA and derivatives of reactive oxygen species (an oxidative index; r = -0.3; p <= 0.05) are inversely correlated. Conversely, the multivariate logistic analysis identified low UA (NANHES-III criteria) as one independent predictor for low global heart T2* (p < 0.5) together with liver iron concentrations (>3 mg/g/dw), heart failure, endocrinopathies, ferritin (>2000 ng/l), alanine transaminase (>40 UI/l) and/or aspartate transaminase (>35 UI/l) and/or glutamyl transferase (>64 UI/l). Discussion: UA appears directly associated to T2* and inversely with derivatives of reactive oxygen species, and as such reduced according to increased oxidative stress and cardiac iron overload in TM patients.
C1 [Vassalle, Cristina; Ndreu, Rudina] Fdn CNR Reg Toscana G Monasterio, Med Lab, Pisa, Italy.
   [Meloni, Antonella; Pistoia, Laura; Positano, Vincenzo; Pepe, Alessia] Fdn CNR Reg Toscana G Monasterio, MRI Unit, Pisa, Italy.
   [Gamberini, Maria Rita] Azienda Osped Univ S Anna, Day Hosp Talassemia & Emoglobinopatie, Unita Operat, Dipartimento Riprod & Accrescimento, Ferrara, Italy.
   [Spasiano, Anna] Azienda Osped Rilievo Nazl A Cardarelli, Dipartimentale Malattie Rare Globulo Rosso, Unita Operat Semplice, Naples, Italy.
   [Gerardi, Calogera] Presidio Osped Giovanni Paolo II Distretto AG2 Sc, Unita Operat Semplice Talassemia, Sciacca, Italy.
   [Zuccarelli, Angelo] ATS Sardegna ASSL Carbonia, UO Med Trasfus, Carbonia, Italy.
   [Casini, Tommaso] Osped Meyer, Ctr Talassemie & Emoglobinopatie, Florence, Italy.
   [Righi, Riccardo] Osped Delta, Diagnost Immagini & Radiol Interventist, Lagosanto, FE, Italy.
   [Missere, Massimiliano] Fdn Ric & Cura Giovanni Paolo II, Dipartimento Immagini, Campobasso, Italy.
C3 University of Ferrara; Arcispedale Sant'Anna; Antonio Cardarelli
   Hospital; University of Florence; Azienda Ospedaliera Universitaria
   (AOU) MEYER; IRCCS Istituto Tumori Bari Giovanni Paolo II
RP Vassalle, C (corresponding author), Fdn CNR Reg Toscana G Monasterio, Med Lab, Pisa, Italy.
EM cristina.vassalle@ftgm.it
RI Pistoia, Laura/AAI-9042-2020; PEPE, ALESSIA/A-7819-2012; Positano,
   Vincenzo/A-6953-2008; Meloni, Antonella/AHE-7577-2022
OI Positano, Vincenzo/0000-0001-6955-9572; Meloni,
   Antonella/0000-0002-2284-8585; Ndreu, Rudina/0000-0003-1198-9822
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NR 45
TC 5
Z9 5
U1 0
U2 6
PU FUTURE MEDICINE LTD
PI LONDON
PA UNITEC HOUSE, 3RD FLOOR, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON, N3
   1QB, ENGLAND
SN 1752-0363
EI 1752-0371
J9 BIOMARK MED
JI Biomark. Med.
PD APR
PY 2018
VL 12
IS 4
BP 341
EP 348
DI 10.2217/bmm-2017-0300
PG 8
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA GK6AN
UT WOS:000436262900005
PM 29569468
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Poredos, P
   Poredos, AV
   Gregoric, I
AF Poredos, Pavel
   Visnovic Poredos, Aleksandra
   Gregoric, Igor
TI Endothelial Dysfunction and Its Clinical Implications
SO ANGIOLOGY
LA English
DT Review
DE endothelial dysfunction; risk factors; investigation of endothelial
   function; therapeutic intervention
ID NITRIC-OXIDE SYNTHASE; VON-WILLEBRAND-FACTOR; C-REACTIVE PROTEIN; OXYGEN
   SPECIES ROS; OXIDATIVE STRESS; CARDIOVASCULAR EVENTS;
   ARTERIAL-HYPERTENSION; PLASMINOGEN-ACTIVATOR; SUPEROXIDE-PRODUCTION;
   METABOLIC SYNDROME
AB Endothelial dysfunction (ED) plays a substantial role in the pathogenesis of atherosclerosis and some other vascular diseases. ED has been demonstrated in patients with hypercholesterolemia, diabetes, smoking, hypertension, and in patients with atherosclerotic disease. Besides classical risk factors, ED is affected by chronic inflammatory diseases and acute infections, particularly viral diseases. Causes of ED include oxidative stress, inflammation, and shear stress, which decrease the bioavailability of nitric oxide. Markers of ED have been sought, particularly circulating markers. Using these tests, it is possible to evaluate the response to harmful effects of risk factors and the effects of treatment on vessel wall function. Endothelial dysfunction is significantly and directly correlated with the occurrence of cardiac events and the risk of cardiac events increase as ED worsens. Because endothelial function plays a central role in atherogenesis it became a therapeutic target. Endothelial dysfunction is reversible and its improvement may be achieved by elimination of risk factors, inhibitors of endothelium-derived contracting factors (angiotensin-converting enzyme), smoking cessation, lipid-lowering drugs, diet, and physical exercise. By reversing ED, it is possible to restore vascular function.
C1 [Poredos, Pavel] Univ Med Ctr Ljubljana, Dept Vasc Dis, Zaloska 7, SI-1000 Ljubljana, Slovenia.
   [Poredos, Pavel; Gregoric, Igor] Univ Texas Hlth Sci Ctr Houston, Dept Adv Cardiopulm Therapies & Transplantat, Houston, TX 77030 USA.
   [Visnovic Poredos, Aleksandra] Community Hlth Ctr Ljubljana, Unit Siska, Ljubljana, Slovenia.
C3 University Medical Centre Ljubljana; University of Texas System;
   University of Texas Health Science Center Houston
RP Poredos, P (corresponding author), Univ Med Ctr Ljubljana, Dept Vasc Dis, Zaloska 7, SI-1000 Ljubljana, Slovenia.
EM pavel.poredos@kclj.si
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NR 141
TC 79
Z9 83
U1 2
U2 14
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0003-3197
EI 1940-1574
J9 ANGIOLOGY
JI Angiology
PD AUG
PY 2021
VL 72
IS 7
BP 604
EP 615
AR 0003319720987752
DI 10.1177/0003319720987752
EA JAN 2021
PG 12
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA SY4JG
UT WOS:000637920100001
PM 33504167
DA 2025-06-11
ER

PT J
AU Mietus-Snyder, ML
   Lustig, RH
AF Mietus-Snyder, Michele L.
   Lustig, Robert H.
TI Childhood obesity: Adrift in the "Limbic Triangle"
SO ANNUAL REVIEW OF MEDICINE
SE Annual Review of Medicine
LA English
DT Review; Book Chapter
DE chronic disease; hypothalamus; insulin; cortisol; environment
ID RELATIVE BODY-WEIGHT; INSULIN-RESISTANCE; PHYSICAL-ACTIVITY;
   HYPOTHALAMIC OBESITY; METABOLIC SYNDROME; CHRONIC STRESS; DIETARY FIBER;
   RISK-FACTORS; MASS INDEX; FAST-FOOD
AB The prevalence and severity of childhood obesity have increased steadily over the post three decades. The human species evolved to rigorously defend its lower limit for weight and adiposity but is tolerant of the upper limit, which, until recent times, was rarely approached. Neuroendocrine mechanisms within the limbic core of the brain prevent starvation (ventromedial hypothalamus), heighten reward (ventral tegmental area and nucleus accumbens), and attenuate stress (amygdala), in order to promote food-seeking and ingestive behavior and to conserve energy output. In a stressful modern environment with ready access to calorie-dense, highly palatable foods and limited venues for activity, normal, reflexive responsiveness to these three drives makes weight gain all but inevitable. The obesity that ensues often engenders insulin resistance, which undermines the ability of normal hunger and satiety signals to accurately modulate energy intake versus expenditure. Obesity interventions that rely on cognitive information alone cannot free children from this "limbic triangle." Integrated multidisciplinary family- and community-based education, effective stress reduction, and a societal commitment to alter the food and built environments are all necessary components to battle the global obesity epidemic.
C1 [Mietus-Snyder, Michele L.; Lustig, Robert H.] Univ Calif San Francisco, Dept Pediat, San Francisco, CA 94143 USA.
C3 University of California System; University of California San Francisco
RP Mietus-Snyder, ML (corresponding author), Univ Calif San Francisco, Dept Pediat, San Francisco, CA 94143 USA.
EM mietussnyclerm@peds.ucsf.edu; rlustig@peds.ucsf.edu
RI Lustig, Robert/O-9380-2019
OI Mietus-Snyder, Michele/0000-0003-2791-9896
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NR 107
TC 39
Z9 46
U1 0
U2 9
PU ANNUAL REVIEWS
PI PALO ALTO
PA 4139 EL CAMINO WAY, PO BOX 10139, PALO ALTO, CA 94303-0139 USA
SN 0066-4219
J9 ANNU REV MED
JI Annu. Rev. Med.
PY 2008
VL 59
BP 147
EP 162
DI 10.1146/annurev.med.59.103106.105628
PG 16
WC Medicine, Research & Experimental
WE Book Citation Index – Science (BKCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 265YJ
UT WOS:000253397600010
PM 17845135
OA Bronze, Green Submitted
DA 2025-06-11
ER

PT J
AU Xiao, JM
   Huang, J
   Long, YJ
   Wang, XY
   Wang, Y
   Yang, Y
   Hei, GR
   Sun, MX
   Zhao, J
   Li, L
   Shao, TN
   Wang, WY
   Kang, DY
   Liu, CC
   Xie, P
   Huang, YY
   Wu, RR
   Zhao, JP
AF Xiao, Jingmei
   Huang, Jing
   Long, Yujun
   Wang, Xiaoyi
   Wang, Ying
   Yang, Ye
   Hei, Gangrui
   Sun, Mengxi
   Zhao, Jin
   Li, Li
   Shao, Tiannan
   Wang, Weiyan
   Kang, Dongyu
   Liu, Chenchen
   Xie, Peng
   Huang, Yuyan
   Wu, Renrong
   Zhao, Jingping
TI Optimizing and Individualizing the Pharmacological Treatment of
   First-Episode Schizophrenic Patients: Study Protocol for a Multicenter
   Clinical Trial
SO FRONTIERS IN PSYCHIATRY
LA English
DT Article
DE first-episode schizophrenic patients; optimized and individualized
   treatment; metabolic syndrome; biomarker; efficacy and adverse effects
AB Introduction: Affecting similar to 1% of the world population, schizophrenia is known as one of the costliest and most burdensome diseases worldwide. Antipsychotic medications are the main treatment for schizophrenia to control psychotic symptoms and efficiently prevent new crises. However, due to poor compliance, 74% of patients with schizophrenia discontinue medication within 1.5 years, which severely affects recovery and prognosis. Through research on intra and interindividual variability based on a psychopathology-neuropsychology-neuroimage-genetics-physiology-biochemistry model, our main objective is to investigate an optimized and individualized antipsychotic-treatment regimen and precision treatment for first-episode schizophrenic patients.
   Methods and Analysis: The study is performed in 20 representative hospitals in China. Three subprojects are included. In subproject 1, 1,800 first-episode patients with schizophrenia are randomized into six different antipsychotic monotherapy groups (olanzapine, risperidone, aripiprazole, ziprasidone, amisulpride, and haloperidol) for an 8-week treatment. By identifying a set of potential biomarkers associated with antipsychotic treatment response, we intend to build a prediction model, which includes neuroimaging, epigenetics, environmental stress, neurocognition, eye movement, electrophysiology, and neurological biochemistry indexes. In subproject 2, apart from verifying the prediction model established in subproject 1 based on an independent cohort of 1,800 first-episode patients with schizophrenia, we recruit patients from a verification cohort who did not get an effective response after an 8-week antipsychotic treatment into a randomized double-blind controlled trial with minocycline (200 mg per day) and sulforaphane (3 tables per day) to explore add-on treatment for patients with schizophrenia. Two hundred forty participants are anticipated to be enrolled for each group. In subproject 3, we tend to carry out one trial to construct an intervention strategy for metabolic syndrome induced by antipsychotic treatment and another one to build a prevention strategy for patients at a high risk of metabolic syndrome, which combines metformin and lifestyle intervention. Two hundred participants are anticipated to be enrolled for each group.
   Ethics and Dissemination: The study protocol has been approved by the Medical Ethics committee of the Second Xiangya Hospital of Central South University (No. 2017027). Results will be disseminated in peer-reviewed journals and at international conferences.
C1 [Xiao, Jingmei; Huang, Jing; Long, Yujun; Wang, Xiaoyi; Wang, Ying; Yang, Ye; Hei, Gangrui; Sun, Mengxi; Zhao, Jin; Li, Li; Shao, Tiannan; Wang, Weiyan; Kang, Dongyu; Liu, Chenchen; Xie, Peng; Huang, Yuyan; Wu, Renrong; Zhao, Jingping] Cent South Univ, Xiangya Hosp 2, Natl Clin Res Ctr Mental Disorders, Dept Psychaitry, Changsha, Peoples R China.
C3 Central South University
RP Wu, RR; Zhao, JP (corresponding author), Cent South Univ, Xiangya Hosp 2, Natl Clin Res Ctr Mental Disorders, Dept Psychaitry, Changsha, Peoples R China.
EM wurenrong@csu.edu.cn; zhaojingping@csu.edu.cn
RI Huang, Jing/NCV-0354-2025; Wang, Ying/IXD-9597-2023; sun,
   meng/JGE-3753-2023; 康, 冬禹/HUF-7715-2023; Hei, Gangrui/JEP-0336-2023;
   Long, Yujun/IVH-7897-2023
OI Kang, Dongyu/0000-0002-3897-2302; Long, Yujun/0000-0001-9458-8068
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NR 30
TC 12
Z9 13
U1 3
U2 22
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-0640
J9 FRONT PSYCHIATRY
JI Front. Psychiatry
PD FEB 25
PY 2021
VL 12
AR 611070
DI 10.3389/fpsyt.2021.611070
PG 10
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA QU5RV
UT WOS:000627339600001
PM 33716817
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Xu, P
   Liu, AP
   Li, FN
   Tinkov, AA
   Liu, LJ
   Zhou, JC
AF Xu, Ping
   Liu, Aiping
   Li, Fengna
   Tinkov, Alexey A.
   Liu, Longjian
   Zhou, Ji-Chang
TI Associations between metabolic syndrome and four heavy metals: A
   systematic review and meta-analysis
SO ENVIRONMENTAL POLLUTION
LA English
DT Review
DE Metabolic syndrome; Arsenic; Cadmium; Lead; Mercury
ID BLOOD MERCURY CONCENTRATION; EXAMINATION SURVEY KNHANES; KOREA
   NATIONAL-HEALTH; DIABETES-MELLITUS; OXIDATIVE STRESS; ARSENIC EXPOSURE;
   URINARY CADMIUM; CARDIOVASCULAR-DISEASE; OCCUPATIONAL-EXPOSURE;
   INSULIN-RESISTANCE
AB Four most concerned heavy metal pollutants, arsenic, cadmium, lead, and mercury may share common mechanisms to induce metabolic syndrome (MetS). However, recent studies exploring the relationships between MetS and metal exposure presented inconsistent findings. We aimed to clarify the relationship between heavy metal exposure biomarkers and MetS using a meta-analysis and systematic review approach. Literature search was conducted in international and the Chinese national databases up to June 2020. Of selected studies, we extracted the relevant data and evaluated the quality of each study's methodology. We then calculated the pooled effect sizes (ESs), standardized mean differences (SMDs), and their 95% confidence intervals (CIs) using a random-effect meta-analysis approach followed by stratification analyses for control of potential confounders. Involving 55,536 participants, the included 22 articles covered 52 observational studies reporting ESs and/or metal concentrations on specific metal and gender. Our results show that participants with MetS had significantly higher levels of heavy metal exposure [pooled ES = 1.16, 95% CI: 1.09, 1.23; n = 42, heterogeneity I-2 = 75.6%; and SMD = 0.22, 95% CI: 0.15, 0.29; n = 32, I-2 = 94.2%] than those without MetS. Pooled ESs in the subgroups stratified by arsenic, cadmium, lead, and mercury were 1.04 (95% CI: 0.97, 1.10; n = 8, I-2 = 61.0%), 1.10 (0.95, 1.27; 11, 45.0%), 1.21 (1.00, 1.48; 12, 82.9%), and 1.26 (1.06, 1.48; 11, 67.7%), respectively. Pooled ESs in the subgroups stratified by blood, urine, and the other specimen were 1.22 (95% CI: 1.08, 1.38; n = 26, I-2 = 75.8%), 1.06 (1.00, 1.13; 14, 58.1%), and 2.41 (1.30, 4.43; 2, 0.0%), respectively. In conclusion, heavy metal exposure was positively associated with MetS. Further studies are warranted to examine the effects of individual metals and their interaction on the relationship between MetS and heavy metals. (C) 2021 Elsevier Ltd. All rights reserved.
C1 [Xu, Ping; Liu, Aiping; Li, Fengna; Zhou, Ji-Chang] Sun Yat Sen Univ, Sch Publ Hlth Shenzhen, 170 Gongchang Rd, Shenzhen 518100, Peoples R China.
   [Tinkov, Alexey A.] Yaroslavl State Univ, Yaroslavl 150003, Russia.
   [Tinkov, Alexey A.] Sechenov Univ, IM Sechenov First Moscow State Med Univ, Moscow 119146, Russia.
   [Liu, Longjian] Drexel Univ, Dornsife Sch Publ Hlth, Dept Epidemiol & Biostat, Philadelphia, PA 19104 USA.
   [Zhou, Ji-Chang] Guangdong Prov Engn Lab Nutr Translat, Guangzhou 510080, Peoples R China.
C3 Sun Yat Sen University; Yaroslavl State University; Sechenov First
   Moscow State Medical University; Drexel University
RP Zhou, JC (corresponding author), Sun Yat Sen Univ, Sch Publ Hlth Shenzhen, 170 Gongchang Rd, Shenzhen 518100, Peoples R China.
EM zhoujch8@mail.sysu.edu.cn
RI Liu, Aiping/IWM-1128-2023; Tinkov, Alexey/H-5842-2016
OI Zhou, Ji-Chang/0000-0003-4177-614X
FU National Natural Science Foundation of China [81973038]; Science,
   Technology and Innovation Commission of Shenzhen Municipality, China
   [JCYJ20200109142446804]
FX The study was partially sponsored by the National Natural Science
   Foundation of China (grant number 81973038) and Science, Technology and
   Innovation Commission of Shenzhen Municipality, China (grant number
   JCYJ20200109142446804).
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NR 145
TC 52
Z9 52
U1 3
U2 74
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0269-7491
EI 1873-6424
J9 ENVIRON POLLUT
JI Environ. Pollut.
PD MAR 15
PY 2021
VL 273
AR 116480
DI 10.1016/j.envpol.2021.116480
EA JAN 2021
PG 18
WC Environmental Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology
GA QR7DX
UT WOS:000625376600063
PM 33486246
DA 2025-06-11
ER

PT J
AU Wang, YJ
   Jia, YA
   Li, SQ
   Li, NN
   Zhou, JN
   Liu, JY
   Yang, SY
   Zhang, M
   Panichayupakaranant, P
   Chen, HX
AF Wang, Yajie
   Jia, Yanan
   Li, Shuqin
   Li, Nannan
   Zhou, Jingna
   Liu, Junyu
   Yang, Shuyu
   Zhang, Min
   Panichayupakaranant, Pharkphoom
   Chen, Haixia
TI Gut microbiome-mediated glucose and lipid metabolism mechanism of star
   apple leaf polyphenol-enriched fraction on metabolic syndrome in
   diabetic mice
SO PHYTOMEDICINE
LA English
DT Article
DE Chrysophyllum cainito; Star apple leaf polyphenol; Metabolic syndrome;
   Gut microbiota; Diabetes; Glycolipid metabolism
ID INSULIN-RESISTANCE; IDENTIFICATION; MYRICETIN
AB Background: Diabetes is a kind of metabolic syndrome (MetS) that seriously threatens human health globally. The leaf of star apple (Chrysophyllum cainito L.) is an incompletely explored folk medicine on diabetes. And, the effects and mechanisms on diabetes complicated glycolipid metabolism disorders are unknown till now.
   Purpose: This study aimed to investigate the constituents of star apple leaf polyphenol enriched-fraction (SAP), and elucidate their treatment effects and mechanism on diabetes and accompanied other MetS.
   Methods: The components of SAP were tentatively identified by HPLC-Q-TOF-MS/MS. The antioxidant activity was determined by the scavenging of free radicals and hypoglycemic activities by inhibition of alpha-glucosidase in vitro. HepG2 cells were used for evaluating the alleviation effects of SAP on lipid accumulation. Streptozotocin and high-fat diet induced diabetic mice were grouped to evaluate the effects of different dosages of SAP. 16S rRNA was conducted to analysis gut microbiome-mediated glucose and lipid metabolism mechanism.
   Results: It showed that myricitrin was one of the main active constituents of SAP. SAP not only showed low IC50 on -glucosidase (24.427 +/- 0.626 mu g/mL), OH.(3.680 +/- 0.054 mu g/mL) and ABTS. (9.155 +/- 0.234 mu g/mL), but significantly induced the lipid accumulation in HepG2 cells (p < 0.05). SAP at 200 mg/kg.day significantly decreased the blood glucose, insulin and oral glucose tolerance test value (p < 0.05). The insulin resistance indexes and oxidative stress were alleviated after administration. SAP not only attenuated hepatic lipid deposition, but also reversed the hepatic glycogen storage. 16S rRNA sequencing results revealed that the interaction between SAP and gut microbiota led to the positive regulation of beneficial bacteria including Akkermansia, Unspecified S24_7, Alistipes and Unspecified_Ruminococcaceae, which might be one of the mechanisms of SAP on MetS.
   Conclusion: For the first time, this study explored the regulation effect of star apple leaf polyphenols on the hepatic glycolipid metabolism and studied the underlying mechanism from the view of gut microbiota. These findings indicated that SAP possesses great potential to serve as a complementary medicine for diabetes and associated MetS. It provided scientific evidence for folk complementary medicine on the treatment of diabetescomplicated multiple metabolic disorders.
C1 [Wang, Yajie; Jia, Yanan; Li, Shuqin; Li, Nannan; Zhou, Jingna; Liu, Junyu; Yang, Shuyu; Chen, Haixia] Tianjin Univ, Sch Pharmaceut Sci & Technol, Tianjin Key Lab Modern Drug Delivery & High Effici, Tianjin 300072, Peoples R China.
   [Zhang, Min] Tianjin Agr Univ, Tianjin 300384, Peoples R China.
   [Zhang, Min] Tianjin Univ Sci & Technol, State Key Lab Nutr & Safety, Tianjin 300457, Peoples R China.
   [Panichayupakaranant, Pharkphoom] Prince Songkla Univ, Fac Pharmaceut Sci, Phytomedicine & Pharmaceut Biotechnol Excellence C, Hat Yai 90112, Thailand.
C3 Tianjin University; Tianjin Agricultural University; Tianjin University
   Science & Technology; Prince of Songkla University
RP Chen, HX (corresponding author), Tianjin Univ, Sch Pharmaceut Sci & Technol, Tianjin Key Lab Modern Drug Delivery & High Effici, Tianjin 300072, Peoples R China.
EM chenhx@tju.edu.cn
RI Li, Nannan/HGD-2792-2022; zhang, min/IYI-9869-2023; PANICHAYUPAKARANANT,
   PHARKPHOOM/X-5227-2018; Chen, Haixia/K-1661-2015
OI Panichayupakaranant, Pharkphoom/0000-0003-1097-8822; Chen,
   Haixia/0000-0002-2596-9622
FU National Key Research and Development Program of China [2021YFE0110000];
   Tianjin Municipal Science and Technology Foundation [22JCYBJC00160]
FX This work was supported by the grant from National Key Research and
   Development Program of China (Grant No. 2021YFE0110000) and the grant
   from Tianjin Municipal Science and Technology Foundation (Grant No.
   22JCYBJC00160) . We thank Figdraw ( www.figdraw.com ) for the assistance
   in creating Fig. 9 and graphic abstract.
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NR 42
TC 3
Z9 3
U1 6
U2 58
PU ELSEVIER GMBH
PI MUNICH
PA HACKERBRUCKE 6, 80335 MUNICH, GERMANY
SN 0944-7113
EI 1618-095X
J9 PHYTOMEDICINE
JI Phytomedicine
PD JUL
PY 2023
VL 115
AR 154820
DI 10.1016/j.phymed.2023.154820
EA APR 2023
PG 12
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA G4II5
UT WOS:000988807600001
PM 37094426
DA 2025-06-11
ER

PT J
AU Lemos, AJJM
   Peixoto, CA
   Teixeira, AAC
   Luna, RLA
   Rocha, SWS
   Santos, HMP
   Silva, AKS
   Nunes, AKS
   Wanderley-Teixeira, V
AF Lemos, Ana Janaina Jeanine M.
   Peixoto, Christina A.
   Teixeira, Alvaro Aguiar C.
   Luna, Rayana Leal A.
   Rocha, Sura Wanessa S.
   Santos, Hilda Michelly P.
   Silva, Amanda Karolina S.
   Nunes, Ana Karolina S.
   Wanderley-Teixeira, Valeria
TI Effect of the combination of metformin hydrochloride and melatonin on
   oxidative stress before and during pregnancy, and biochemical and
   histopathological analysis of the livers of rats after treatment for
   polycystic ovary syndrome
SO TOXICOLOGY AND APPLIED PHARMACOLOGY
LA English
DT Article
DE Metformin hydrochloride; Melatonin; Polycystic ovary syndrome; Liver;
   Rats; Pregnancy
ID CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; ANTIOXIDANT; GLUCOSE; RISK;
   DEXAMETHASONE; DYSFUNCTION; EXPRESSION; MARKERS; DAMAGE
AB The aim of the present study was to analyze the effect of a combination of metformin hydrochloride and melatonin on oxidative stress together with a biochemical and histopathological analysis of the livers of Wistar rats induced with PCOS. The results indicated that a combination of the drugs was more effective in the reduction of plasmatic levels of liver enzyme alanine aminotransferase, nitric oxide and total glutathione, and decreased the inflammatory response and histopathological damage, producing results that were significantly similar to animals from the control group. A mixture of the drugs produced more effective results against liver toxicity caused by PCOS, encouraging the normalization of biochemical parameters. During pregnancy, there was reduced oxidative stress compared to monotherapeutic use of these drugs. Interestingly, the combination of the drugs caused a physiological reaction similar to responses identified in healthy rats without induction of the PCOS control group. However, the clinical and physiological effectiveness of the combination should be further explored, especially with respect to the possible side effects on offspring. (C) 2014 Elsevier Inc. All rights reserved.
C1 [Lemos, Ana Janaina Jeanine M.; Teixeira, Alvaro Aguiar C.; Santos, Hilda Michelly P.; Wanderley-Teixeira, Valeria] Univ Fed Rural Pernambuco, Dept Anim Morphol & Physiol, Recife, PE, Brazil.
   [Peixoto, Christina A.; Luna, Rayana Leal A.; Rocha, Sura Wanessa S.; Silva, Amanda Karolina S.; Nunes, Ana Karolina S.] Fiocruz MS, Ctr Pesquisa Aggeu Magalhaes, Recife, PE, Brazil.
   [Lemos, Ana Janaina Jeanine M.] Univ Fed Campina Grande, Unit Med & Hlth Sci, Campina Grande, Brazil.
C3 Universidade Federal Rural de Pernambuco (UFRPE); Fundacao Oswaldo Cruz;
   Universidade Federal de Campina Grande
RP Wanderley-Teixeira, V (corresponding author), UFRPE DMFA, Av Dom Manoel de Medeiros S-N, BR-52171900 Recife, PE, Brazil.
EM valeria@dmfa.ufrpe.br
RI Wanderley-Teixeira, Valeria/AAS-6380-2021; PEIXOTO,
   CHRISTINA/AAD-9608-2019; Teixeira, Álvaro/I-2616-2017; ROCHA, SURA
   WANESSA SANTOS/R-8479-2018
OI ROCHA, SURA WANESSA SANTOS/0000-0003-2312-085X
FU Coordination of Improvement of Higher Education Personnel - CAPES
   [20102013]
FX This study was supported by The Coordination of Improvement of Higher
   Education Personnel - CAPES (number 20102013) by award doctorate
   scholarship.
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NR 58
TC 24
Z9 25
U1 0
U2 15
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0041-008X
EI 1096-0333
J9 TOXICOL APPL PHARM
JI Toxicol. Appl. Pharmacol.
PD OCT 1
PY 2014
VL 280
IS 1
BP 159
EP 168
DI 10.1016/j.taap.2014.05.015
PG 10
WC Pharmacology & Pharmacy; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Toxicology
GA AQ1GZ
UT WOS:000342531200018
PM 24918699
DA 2025-06-11
ER

PT J
AU Okutsu, M
   Lira, VA
   Higashida, K
   Peake, J
   Higuchi, M
   Suzuki, K
AF Okutsu, Mitsuharu
   Lira, Vitor A.
   Higashida, Kazuhiko
   Peake, Jonathan
   Higuchi, Mitsuru
   Suzuki, Katsuhiko
TI Corticosterone accelerates atherosclerosis in the apolipoprotein
   E-deficient mouse
SO ATHEROSCLEROSIS
LA English
DT Article
DE Stress; Dyslipidaemia; Cholesterol; Hypothalamic-pituitary-adrenal axis;
   ApoE-deficient mice
ID CARDIOVASCULAR-DISEASE; CARDIORESPIRATORY FITNESS; RHEUMATOID-ARTHRITIS;
   INFLAMMATORY DISEASE; DOSE CORTICOSTERONE; METABOLIC SYNDROME;
   CUSHINGS-SYNDROME; MICE; CHOLESTEROL; OBESITY
AB Chronic stress is an important risk factor for atherosclerosis, which is a chief process in the development of cardiovascular disease. Increased circulating levels of corticosterone have been documented in several animal models of chronic stress. However, it remains to be established whether corticosterone is sufficient to exacerbate atherosclerosis. To test this hypothesis, apolipoprotein E (ApoE)-deficient mice were fed a high-fat diet for 13 weeks with exposure to either corticosterone or vehicle in the drinking water (CORT and Con). Corticosterone treatment significantly increased atherosclerotic plaque area at the aortic root. Such exacerbation of atherosclerosis was accompanied by significantly lower levels of circulating white blood cells and serum interleukin-1 beta (IL-1 beta), and significantly elevated serum concentrations of total cholesterol, low-density lipoprotein (LDL), very-low-density lipoprotein (VLDL) and small dense low-density lipoprotein (sd-LDL) in CORT mice when compared to Con mice. These findings demonstrate that corticosterone is sufficient to exacerbate atherosclerosis in vivo despite its anti-inflammatory properties and that this marked pro-atherogenic phenotype is primarily associated with increased dyslipidaemia. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
C1 [Okutsu, Mitsuharu; Higashida, Kazuhiko; Higuchi, Mitsuru; Suzuki, Katsuhiko] Waseda Univ, Fac Sport Sci, Tokorozawa, Saitama 3591192, Japan.
   [Lira, Vitor A.] Univ Iowa, Dept Hlth & Human Physiol, Iowa City, IA USA.
   [Peake, Jonathan] Queensland Univ Technol, Sch Biomed Sci, Brisbane, Qld 4001, Australia.
   [Okutsu, Mitsuharu; Higuchi, Mitsuru; Suzuki, Katsuhiko] Waseda Univ, Inst Biomed Engn, Consolidated Res Inst Adv Sci & Med Care, Tokyo, Japan.
   [Lira, Vitor A.] Univ Iowa, Obes Res & Educ Initiat, Iowa City, IA USA.
   [Lira, Vitor A.] Univ Iowa, Fraternal Order Eagles Diabet Res Ctr, Iowa City, IA USA.
C3 Waseda University; University of Iowa; Queensland University of
   Technology (QUT); Waseda University; University of Iowa; University of
   Iowa
RP Okutsu, M (corresponding author), Waseda Univ, Fac Sport Sci, 2-579-15 Mikashima, Tokorozawa, Saitama 3591192, Japan.
EM mitsu.okutsu@aoni.waseda.jp
RI Lira, Vitor/AAN-3403-2021; Suzuki, Katsuhiko/AAI-2197-2019; Peake,
   Jonathan/F-4114-2010
OI Peake, Jonathan/0000-0002-8218-0038; Suzuki,
   Katsuhiko/0000-0002-6572-5809
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NR 48
TC 17
Z9 17
U1 1
U2 15
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0021-9150
EI 1879-1484
J9 ATHEROSCLEROSIS
JI Atherosclerosis
PD FEB
PY 2014
VL 232
IS 2
BP 414
EP 419
DI 10.1016/j.atherosclerosis.2013.11.076
PG 6
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 302DV
UT WOS:000330582700049
PM 24468157
OA Green Published
DA 2025-06-11
ER

PT B
AU Nicolaides, NC
   Charmandari, E
   Chrousos, GP
   Kino, T
AF Nicolaides, Nicolas C.
   Charmandari, Evangelia
   Chrousos, George P.
   Kino, Tomoshige
BE Cutolo, M
   Straub, RH
   Masi, AT
   Bijlsma, JWJ
TI Circadian endocrine rhythms: the hypothalamic-pituitary-adrenal axis and
   its actions
SO STEROIDS IN NEUROENDOCRINE IMMUNOLOGY AND THERAPY OF RHEUMATIC DISEASES
   II
SE Annals of the New York Academy of Sciences-Series
LA English
DT Article; Proceedings Paper
CT 5th International Conference on the Neuroendocrine Immune Basis of the
   Rheumatic Diseases (NEIRD)
CY OCT 01-03, 2013
CL Genoa, ITALY
DE HPA axis; circadian clock system; glucocorticoids; glucocorticoid
   receptor; acetylation
ID HUMAN GLUCOCORTICOID-RECEPTOR; PERIPHERAL-TISSUES; METABOLIC SYNDROME;
   SHIFT WORK; TRANSCRIPTIONAL ACTIVITY; RHEUMATOID-ARTHRITIS; CLOCK; GENE;
   EXPRESSION; MECHANISMS
AB The stress system effectively restores the internal balance-or homeostasis-of living organisms in the face of random external or internal changes, the stressors. This highly complex system helps organisms to provide a series of neuroendocrine responses to stressors-the stress response-through coordinated activation of the hypothalamic-pituitary-adrenal (HPA) axis and the locus coeruleus/norepinephrine autonomic nervous systems. In addition to stressors, life is influenced by daily light/dark changes due to the 24-h rotation of Earth. To adjust to these recurrent day/night cycles, the biological clock system employs the heterodimer of transcription factors circadian locomotor output cycle kaput/brain-muscle-arnt-like protein 1 (CLOCK/BMAL1), along with a set of other transcription factors, to regulate the circadian pattern of gene expression. Interestingly, the stress system, through the HPA axis, communicates with the clock system; therefore, any uncoupling or dysregulation could potentially cause several disorders, such as metabolic, autoimmune, and mood disorders. In this review, we discuss the biological function of the two systems, their interactions, and the clinical implications of their dysregulation or uncoupling.
C1 [Nicolaides, Nicolas C.; Charmandari, Evangelia; Chrousos, George P.] Univ Athens, Aghia Sophia Childrens Hosp, Sch Med, Dept Pediat 1,Div Endocrinol Metab & Diabet, Athens, Greece.
   [Nicolaides, Nicolas C.; Charmandari, Evangelia; Chrousos, George P.] Biomed Res Fdn Acad Athens, Clin Res Ctr, Div Endocrinol & Metab, Athens 11527, Greece.
   [Chrousos, George P.] King Abdulaziz Univ, King Fahd Med Res Ctr, Saudi Diabet Study Res Grp, Jeddah 21413, Saudi Arabia.
   [Kino, Tomoshige] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Program Reprod & Adult Endocrinol, NIH, Bethesda, MD USA.
C3 The Aghia Sophia Children's Hospital; National & Kapodistrian University
   of Athens; Athens Medical School; Academy of Athens; King Abdulaziz
   University; National Institutes of Health (NIH) - USA; NIH Eunice
   Kennedy Shriver National Institute of Child Health & Human Development
   (NICHD)
RP Nicolaides, NC (corresponding author), Biomed Res Fdn Acad Athens, Clin Res Ctr, Div Endocrinol & Metab, 4 Soranou Tou Efessiou St, Athens 11527, Greece.
EM nnicolaides@bioacademy.gr
RI Chrousos, George/G-8702-2011; Charmandari, Evangelia/AAF-2038-2019
OI Charmandari, Evangelia/0000-0002-0851-6998
FU European Union (European Social Fund, ESF); intramural program of the
   Eunice Kennedy Shriver National Institute of Child Health and Human
   Development, National Institutes of Health, Bethesda, Maryland
FX This work was supported by (1) the European Union (European Social Fund,
   ESF) and Greek national funds through the operational program "Education
   and Lifelong Learning" of the National Strategic Reference Framework
   Research Funding Program THALIS, University of Athens, Athens, Greece;
   and (2) the intramural program of the Eunice Kennedy Shriver National
   Institute of Child Health and Human Development, National Institutes of
   Health, Bethesda, Maryland.
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NR 77
TC 125
Z9 140
U1 1
U2 48
PU BLACKWELL SCIENCE PUBL
PI OXFORD
PA OSNEY MEAD, OXFORD OX2 0EL, ENGLAND
J9 ANN NY ACAD SCI
JI Ann.NY Acad.Sci.
PY 2014
VL 1318
BP 71
EP 80
DI 10.1111/nyas.12464
PG 10
WC Endocrinology & Metabolism; Immunology; Rheumatology
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Immunology; Rheumatology
GA BA7XF
UT WOS:000337847000010
PM 24890877
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Zhang, Q
   Wu, YM
   Luo, B
AF Zhang, Qu
   Wu, Yemei
   Luo, Bo
TI Association of oxidative balance score with metabolic syndrome and its
   components in middle-aged and older individuals in the United States
SO FRONTIERS IN NUTRITION
LA English
DT Article
DE metabolic syndrome; oxidative balance score; middle-aged and older
   individuals; National Health and Nutrition Examination Survey; dietary
   and lifestyle factors
ID STRESS; INFLAMMATION; HEALTH
AB Background The prevalence of metabolic syndrome (MetS) among middle-aged and older individuals in the U.S. is rising, posing significant mortality risks. Diet is a key factor in MetS development, yet few studies have examined the combined effects of dietary and lifestyle factors on MetS in this group. Recently, the oxidative balance score (OBS), an indicator of oxidative status encompassing diet and physical activity, has attracted interest. This study explores the association between OBS and MetS, as well as its individual components, in middle-aged and older Americans. Methods Data from 6,157 participants aged 45 years and older in the National Health and Nutrition Examination Survey (NHANES) (1999-2018) were analyzed. The OBS was calculated using 16 dietary and four lifestyle factors. Logistic regression was used to assess associations between OBS and MetS. Separate analyses examined dietary OBS (DOBS) and lifestyle OBS (LOBS) in relation to MetS. Results Higher OBS quartiles were associated with a reduced MetS risk (OR 0.25; 95% confidence interval [CI]: 0.12-0.51; p < 0.0001), after adjusting for confounders. Increased OBS was linked to decreases in waist circumference (WC) (OR 0.41; 95% CI: 0.30-0.51; p < 0.0001), triglycerides (TG) (OR 0.71; 95% CI: 0.53-0.92; p = 0.0139), blood pressure (BP) (OR 0.53; 95% CI: 0.40-0.69; p < 0.0001), and fasting glucose (FG) (OR 0.61; 95% CI: 0.45-0.81; p < 0.0001), while HDL-C increased (OR 0.68; 95% CI: 0.51-0.90; p = 0.0065). DOBS was inversely associated with MetS through reductions in BP and FG and increased HDL-C, though it showed no significant effect on WC or TG. LOBS was associated with reductions across WC, BP, FG, TG, and an increase in HDL-C. Conclusion OBS is inversely associated with MetS in middle-aged and older U.S. adults. Enhancing OBS through dietary guidelines emphasizing antioxidant-rich foods, fiber, and unsaturated fats, alongside lifestyle changes like regular exercise, smoking cessation, and moderate alcohol intake, may be crucial in MetS prevention for this population.
C1 [Zhang, Qu; Luo, Bo] Huazhong Univ Sci & Technol, Natl Key Clin Specialty Construct Discipline, Dept Radiotherapy Ctr, Breast Canc Ctr,Hubei Prov Clin Res Ctr Breast Can, Wuhan, Peoples R China.
   [Wu, Yemei] Huazhong Univ Sci & Technol, Hubei Canc Hosp, Tongji Med Coll, Wuhan, Peoples R China.
C3 Huazhong University of Science & Technology; Huazhong University of
   Science & Technology
RP Luo, B (corresponding author), Huazhong Univ Sci & Technol, Natl Key Clin Specialty Construct Discipline, Dept Radiotherapy Ctr, Breast Canc Ctr,Hubei Prov Clin Res Ctr Breast Can, Wuhan, Peoples R China.; Wu, YM (corresponding author), Huazhong Univ Sci & Technol, Hubei Canc Hosp, Tongji Med Coll, Wuhan, Peoples R China.
EM wuyemei2010@163.com; 375602596@qq.com
FU Hubei Cancer Hospital [20162017B01, HBCHBCC-D04]
FX The author(s) declare that financial support was received for the
   research, authorship, and/or publication of this article. This study was
   supported by Hubei Cancer Hospital (grant nos. 20162017B01 and
   HBCHBCC-D04).
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NR 34
TC 0
Z9 0
U1 3
U2 3
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD FEB 6
PY 2025
VL 12
AR 1523791
DI 10.3389/fnut.2025.1523791
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA X5T4A
UT WOS:001425967900001
PM 39980681
OA gold
DA 2025-06-11
ER

PT J
AU Wang, M
   Ma, GS
   Tao, ZX
AF Wang, Mi
   Ma, Genshan
   Tao, Zaixiao
TI The association of neutrophil-to-lymphocyte ratio with cardiovascular
   and all-cause mortality among the metabolic syndrome population
SO BMC CARDIOVASCULAR DISORDERS
LA English
DT Article
DE Neutrophil-to-lymphocyte ratio; NLR; Metabolic syndrome; MetS;
   Mortality; NHANES
ID OXIDATIVE STRESS; INFLAMMATION; COMPONENTS; PREVALENCE; OBESITY; TRENDS
AB Background The neutrophil-to-lymphocyte ratio (NLR) has emerged as a novel inflammatory marker related to disease prognosis, this study aimed to evaluate the association between NLR and mortality in metabolic syndrome (MetS) patients. Methods This study used data from 13,156 participants with MetS, derived from the National Health and Nutrition Examination Survey from 1999 to 2020. The NLR was calculated, and its associations with cardiovascular disease (CVD) mortality and all-cause mortality were assessed by multivariate Cox regression, restricted cubic spline and Kaplan-Meier curves. The study performed subgroup analyses to validate the robustness of the findings in different populations. The predictive ability of NLR was evaluated using time-dependent receiver operating characteristic curve. The indirect impact of eGFR was explored by mediation analysis. Results As NLR values increased, there was an obvious rise in the risk of mortality in MetS. The fully adjusted continuous model revealed a 16.0%, 14.4% elevated risk of CVD mortality (HR = 1.160; 95% CI: 1. 090-1.234, p < 0.0001) and all-cause mortality (HR = 1.144; 95% CI: 1. 086-1.206, p < 0.0001), respectively, with each one-unit increment in NLR. Comparing the highest to the lowest quartile of NLR, the top quartile exhibited a significantly increased risk of CVD mortality (HR = 2. 447; 95% CI: 1. 561-3. 836, p < 0.0001), and all-cause mortality (HR = 1. 53; 95% CI: 1. 188-1. 972, p = 0.001) among individuals with MetS. Subgroup analyses substantiated the stability of these associations in most populations. The curve under area for the 3, 5, and 10 years were 0.650, 0.716, and 0.645 for CVD mortality, and 0.746, 0.688, and 0.635 for all-cause mortality. Significantly, the eGFR acted as an intermediary in the relationship of NLR with CVD mortality and all-cause mortality, accounting for 9.85% and 9.86% of the effect, respectively. Conclusion The NLR served as a significant indicator for assessing the risk of mortality in the MetS population. Consequently, we recommended the regular assessment of NLR in MetS populations as a potentially advantageous method for evaluating their risk of mortality.
C1 [Wang, Mi; Ma, Genshan; Tao, Zaixiao] Southeast Univ, Zhongda Hosp, Sch Med, Dept Cardiol, Nanjing, Peoples R China.
   [Wang, Mi; Ma, Genshan; Tao, Zaixiao] Southeast Univ, Sch Med, Nanjing, Peoples R China.
C3 Southeast University - China; Southeast University - China
RP Ma, GS; Tao, ZX (corresponding author), Southeast Univ, Zhongda Hosp, Sch Med, Dept Cardiol, Nanjing, Peoples R China.; Ma, GS; Tao, ZX (corresponding author), Southeast Univ, Sch Med, Nanjing, Peoples R China.
EM magenshan@hotmail.com; taozaixiao@163.com
OI wang, mi/0009-0005-4833-6122
FU Young Scientists Fund of the National Natural Science Foundation of
   China
FX The authors thank the staff and the participants of the NHANES study for
   their valuable contributions.
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NR 40
TC 1
Z9 1
U1 5
U2 6
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1471-2261
J9 BMC CARDIOVASC DISOR
JI BMC Cardiovasc. Disord.
PD OCT 26
PY 2024
VL 24
IS 1
AR 594
DI 10.1186/s12872-024-04284-1
PG 12
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA K3U2D
UT WOS:001343153100009
PM 39462314
OA gold
DA 2025-06-11
ER

PT J
AU Zhao, YN
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AF Zhao, Yining
   Liu, Shuangmei
TI Bioactivity of naringin and related mechanisms
SO PHARMAZIE
LA English
DT Review
ID NF-KAPPA-B; ACUTE LIVER-INJURY; OXIDATIVE STRESS; ANTIMICROBIAL
   ACTIVITY; CITRUS FLAVONOIDS; INDUCED COLITIS; INFLAMMATION; ANTIOXIDANT;
   ACTIVATION; BETA
AB Naringin is a flavonoid compound, which can be used to treat or prevent various diseases, such as obesity, heart disease, diabetes, and metabolic syndrome. The medicinal value of naringin is mainly reflected in its antioxidant and anti-inflammatory functions, and it has a protective effect on pathophysiology. Furthermore, naringin has shown potential to become an alternative as traditional anti-inflammatory drug, because it exerts less side effects than chemically synthesized compounds. In this paper, we are reviewing the specific molecular mechanisms of anti-inflammatory and antioxidant properties of naringin. We analyze and discuss the primary role of naringin in the treatment of diseases such as acute and chronic liver injury, lung injury, bowel disease, and neurodegenerative diseases. Besides, the bactericidal effect of naringin is also reviewed.
C1 [Zhao, Yining] Nanchang Univ, Sch Med, Queen Mary Coll, Nanchang, Jiangxi, Peoples R China.
   [Liu, Shuangmei] Nanchang Univ, Sch Med, Dept Physiol, 999 Xuefu Rd, Nanchang, Jiangxi, Peoples R China.
C3 Nanchang University; Nanchang University
RP Liu, SM (corresponding author), Nanchang Univ, Sch Med, Dept Physiol, 999 Xuefu Rd, Nanchang, Jiangxi, Peoples R China.
EM liushuangmei_1983@163.com
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NR 93
TC 31
Z9 34
U1 4
U2 53
PU AVOXA-MEDIENGRUPPE DEUTSCHER APOTHEKER GMBH
PI ESCHBORN
PA CARL-MANNICH-STR 26, ESCHBORN, GERMANY
SN 0031-7144
J9 PHARMAZIE
JI Pharmazie
PD AUG
PY 2021
VL 76
IS 8
BP 359
EP 363
DI 10.1691/ph.2021.1504
PG 5
WC Chemistry, Medicinal; Chemistry, Multidisciplinary; Pharmacology &
   Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Chemistry
GA UE1FR
UT WOS:000687642600003
PM 34412734
DA 2025-06-11
ER

PT J
AU Broncel, M
   Koziróg, M
   Duchnowicz, P
   Koter-Michalak, M
   Sikora, J
   Chojnowska-Jezierska, J
AF Broncel, Marlena
   Kozirog, Marzena
   Duchnowicz, Piotr
   Koter-Michalak, Maria
   Sikora, Joanna
   Chojnowska-Jezierska, Julita
TI Aronia melanocarpa extract reduces blood pressure, serum
   endothelin, lipid, and oxidative stress marker levels in patients with
   metabolic syndrome
SO MEDICAL SCIENCE MONITOR
LA English
DT Article
DE anthocyanins; metabolic syndrome; lipids; peroxidation; endothelin-1
ID CRANBERRY JUICE CONSUMPTION; PLASMA ANTIOXIDANT CAPACITY; HEART-DISEASE;
   SUPPLEMENTATION; ANTHOCYANINS; CATECHINS; RATS; PEROXIDATION;
   CHOLESTEROL; MEN
AB Background: Experimental studies have shown that anthocyanins may exert pleiotropic effects. The aim of the study was to determine the influence of Aronia melanocarpa extract on blood pressure and serum concentration of endothelin-1 (ET-1), lipids, glucose, uric acid, C-reactive protein (CRP), fibrinogen, the antioxidant enzymes catalase (CAT), superoxide dysmutase (SOD), and glutathione peroxidase (GSH-Px), and lipid peroxidation (thiobarbituric acid-reacting substrates, TBARS) in erythrocytes of patients with metabolic syndrome (MS).
   Material/Methods: The study comprised 22 healthy volunteers and 25 patients with MS. Patients with MS were treated with aronia extract (3x100 mg/day) for two months. The above parameters were measured.
   Results: After two months of therapy, statistically significant decreases were observed in SBP (143.40 +/- 7.87 vs. 131.83 +/- 12.24 mmHg, p < 0.001), DBP (87.20 +/- 9.9 vs. 82.13 +/- 10.33 mmHg, p < 0.05), ET-1 (2.44 +/- 0.51 vs. 1.74 +/- 0.42 pg/ml, p < 0.001), TC (242.80 +/- 34.48 vs. 227.96 +/- 33.07 mg/dl, p < 0.001), LDL-C (158.71 +/- 35.78 vs. 146.21 +/- 34.63 mg/dl, p < 0.01), TG (215.92 +/- 63.61 vs. 187.58 +/- 90 mg/dl, p < 0.05), TBARS (0.0712 +/- 0.0191 vs. 0.0362 +/- 0.0135 mu mol/g-Hb, p < 0.001), and CAT (261.30 +/- 59.78 vs. 213.34 +/- 47.36 U/mg-Hb) and significant increases in SOD (2380.63 +/- 419.91 vs. 3066.53 +/- 542.24 U/g-Hb, p < 0.001), GSH-Px (12.60 +/- 5.97 vs. 19.18 +/- 9.09 U/g-Hb, p < 0.01), and fibrinogen levels (249.20 +/- 27.17 vs. 276.67 +/- 57.41 mg/dl, p < 0.05) compared with the baseline values.
   Conclusions: Aronia extract may be of benefit to patients with MS. This seems to result from the influence of anthocyanins and possibly other flavonoids on blood pressure, serum level of ET-1, lipids, and oxidative status (GSH-Px, SOD, TBARS).
C1 [Broncel, Marlena; Kozirog, Marzena; Chojnowska-Jezierska, Julita] Med Univ Lodz, Dept Internal Dis, Clin Pharmacol & Therapy Monitoring Unit, PL-91347 Lodz, Poland.
   [Duchnowicz, Piotr; Koter-Michalak, Maria] Univ Lodz, Dept Environm Pollut Biophys, PL-90131 Lodz, Poland.
   [Sikora, Joanna] Med Univ Lodz, Dept Pharmaceut Chem & Drug Anal, PL-91347 Lodz, Poland.
C3 Medical University Lodz; University of Lodz; Medical University Lodz
RP Broncel, M (corresponding author), Med Univ Lodz, Dept Internal Dis, Clin Pharmacol & Therapy Monitoring Unit, Kniaziewicza 1-5 Str, PL-91347 Lodz, Poland.
EM ttm@ttm.org.pl
RI Sikora, Joanna/J-5197-2012; Duchnowicz, Piotr/F-2162-2018
OI Koter-Michalak, Maria/0000-0001-8660-4136; Broncel,
   Marlena/0000-0003-3659-8115; Duchnowicz, Piotr/0000-0002-3514-9716
FU Medical University of Lodz [503-5006-3]; University of Lodz, Poland
   [505/371]
FX This work was supported by statutory grant No. 503-5006-3 of the Medical
   University of Lodz and grant No. 505/371 of the University of Lodz,
   Poland
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NR 43
TC 125
Z9 136
U1 0
U2 37
PU INT SCIENTIFIC LITERATURE, INC
PI ALBERTSON
PA 1125 WILLIS AVE, ALBERTSON, NY 11507 USA
SN 1234-1010
J9 MED SCI MONITOR
JI Med. Sci. Monitor
PY 2010
VL 16
IS 1
BP CR28
EP CR34
PG 7
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 537NT
UT WOS:000273120400015
PM 20037491
DA 2025-06-11
ER

PT J
AU Timoteo, VJ
   Chiang, KM
   Pan, WH
AF Timoteo, Vanessa Joy
   Chiang, Kuang-Mao
   Pan, Wen-Harn
TI Positive or U-Shaped Association of Elevated Hemoglobin Concentration
   Levels with Metabolic Syndrome and Metabolic Components: Findings from
   Taiwan Biobank and UK Biobank
SO NUTRIENTS
LA English
DT Article
DE hemoglobin; iron nutrition status; metabolic syndrome; metabolic
   disorders; observational study; Taiwanese Han Chinese; European White
ID HEMATOLOGICAL PARAMETERS; OXIDATIVE STRESS; IRON OVERLOAD; URIC-ACID;
   HEART-DISEASE; ANEMIA; BLOOD; GUIDELINES; OBESITY; HEALTH
AB Iron overnutrition has been implicated with a higher risk of developing metabolic and cardiovascular diseases, including metabolic syndrome (MetS), whereas iron deficiency anemia exacerbates many underlying chronic conditions. Hemoglobin (Hb) concentration in the blood, which reflects a major functional iron (i.e., heme iron) in the body, may serve as a surrogate of the nutritional status of iron. We conducted sex-specific observational association studies in which we carefully titrated the association between Hb deciles and MetS and its components among the Taiwanese Han Chinese (HC) from the Taiwan Biobank and Europeans of White ancestry from the UK Biobank, representing two large ethnicities. Our data show that at higher-than-normal levels of Hb, increasing deciles of Hb concentration were significantly associated with MetS across all sex subgroups in both ethnicities, with the highest deciles resulting in up to three times greater risk than the reference group [Taiwanese HC: OR = 3.17 (95% CI, 2.75-3.67) for Hb >= 16.5 g/dL in men, OR = 3.11 (2.78-3.47) for Hb >= 14.5 g/dL in women; European Whites: OR = 1.89 (1.80-1.98) for Hb >= 16.24 g/dL in men, OR = 2.35 (2.24-2.47) for Hb >= 14.68 g/dL in women]. The association between stronger risks and increasing Hb deciles was similarly observed with all metabolic components except diabetes. Here we found that both the highest Hb decile groups and contrarily the lowest ones, with respect to the reference, were associated with higher odds of diabetes in both ethnic groups [e.g., Taiwanese HC men: OR = 1.64 (1.33-2.02) for Hb >= 16.5 g/dL, OR = 1.71 (1.39-2.10) for Hb <= 13.5 g/dL; European Whites women: OR = 1.39 (1.26-1.45) for Hb >= 14.68 g/dL, OR = 1.81 (1.63-2.01) for Hb <= 12.39 g/dL]. These findings confirm that elevated Hb concentrations, a potential indicator of iron overnutrition, may play a role in the pathophysiology of MetS and metabolic components.
C1 [Timoteo, Vanessa Joy] Natl Yang Ming Chiao Tung Univ, Taiwan Int Grad Program Mol Med, Taipei 115, Taiwan.
   [Timoteo, Vanessa Joy] Acad Sinica, Taipei 115, Taiwan.
   [Timoteo, Vanessa Joy; Chiang, Kuang-Mao; Pan, Wen-Harn] Acad Sinica, Inst Biomed Sci, Taipei 115, Taiwan.
C3 National Yang Ming Chiao Tung University; Academia Sinica - Taiwan;
   Academia Sinica - Taiwan
RP Pan, WH (corresponding author), Acad Sinica, Inst Biomed Sci, Taipei 115, Taiwan.
EM pan@ibms.sinica.edu.tw
RI Pan, Wen-Harn/F-9972-2010
OI Pan, Wen-Harn/0000-0001-9136-0658; Timoteo, Vanessa
   Joy/0000-0002-5827-8510
FU Health Cloud Project of Academia Sinica [AS-PH-109-02]
FX This research was funded by the Health Cloud Project of Academia Sinica
   with grant number AS-PH-109-02.
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NR 85
TC 8
Z9 8
U1 0
U2 4
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD OCT
PY 2022
VL 14
IS 19
AR 4007
DI 10.3390/nu14194007
PG 20
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 5I0VX
UT WOS:000868086800001
PM 36235661
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Pleasant, RS
   Suagee, JK
   Thatcher, CD
   Elvinger, F
   Geor, RJ
AF Pleasant, R. S.
   Suagee, J. K.
   Thatcher, C. D.
   Elvinger, F.
   Geor, R. J.
TI Adiposity, Plasma Insulin, Leptin, Lipids, and Oxidative Stress in
   Mature Light Breed Horses
SO JOURNAL OF VETERINARY INTERNAL MEDICINE
LA English
DT Article
DE Body condition; Equine metabolic syndrome; Leptin; Lipids; Plasma
   insulin
ID PASTURE-ASSOCIATED LAMINITIS; EQUINE LAMINITIS; BODY CONDITION;
   WEIGHT-GAIN; PONIES; SENSITIVITY; HORMONE; HYPERINSULINEMIA; PREVALENCE;
   RESISTANCE
AB Background Increased blood insulin levels are associated with an increased risk of pasture-associated laminitis in equids. Objective To determine the relationship between plasma insulin, leptin, and lipid levels, and measures of oxidative stress with adiposity in mature light breed horses. Animals 300 randomly selected light breed horses, aged 420years. Methods A random sample of horses (140 mares, 151 geldings, and 9 stallions) was drawn from the VMRCVM Equine Field Service practice client list. Evaluations occurred June 15 August 15, 2006, with all sampling performed between 0600 and 1200hours. Concentrate feed was withheld for at least 10hours before sampling. Plasma was analyzed for insulin, glucose, leptin, triglycerides, nonesterified fatty acids, and measures of oxidative stress. Body condition score was determined as the average of 2 independent investigators. Results Overconditioned and obese horses had higher plasma insulin (P<.001) and leptin (P<.01) levels than optimally conditioned horses. Obese horses had higher triglyceride levels (P=.006) and lower red blood cell gluthathione peroxidase activities (P=.001) than optimally conditioned horses. Conclusions and Clinical Importance Maintaining horses at a BCS <7 might be important for decreasing the risk of pasture-associated laminitis.
C1 [Pleasant, R. S.; Thatcher, C. D.; Elvinger, F.] Virginia Polytech Inst & State Univ, Virginia Maryland Reg Coll Vet Med, Dept Large Anim Clin Sci, Blacksburg, VA 24061 USA.
   [Suagee, J. K.; Geor, R. J.] Virginia Polytech Inst & State Univ, Dept Anim & Poultry Sci, Blacksburg, VA 24061 USA.
C3 Virginia Polytechnic Institute & State University; Virginia Polytechnic
   Institute & State University
RP Pleasant, RS (corresponding author), Virginia Polytech Inst & State Univ, Virginia Maryland Reg Coll Vet Med, Dept Large Anim Clin Sci, Blacksburg, VA 24061 USA.
EM rpleasan@vt.edu
RI Suagee, Jessica/A-6407-2013; Geor, Raymond/P-4631-2017
OI Geor, Raymond/0000-0002-6825-6737
FU Virginia Horse Industry Board; Virginia Tech [Virginia-Maryland Regional
   College of Veterinary Medicine]; Virginia Tech [College of Agriculture
   and Life Sciences]; Macromolecular Interfaces with Life Sciences (MILES)
   Integrative Graduate Education and Research Traineeship (IGERT) of the
   National Science Foundation [DGE-0333378]
FX This study was supported in part by the Virginia Horse Industry Board,
   Virginia Tech [Virginia-Maryland Regional College of Veterinary Medicine
   and the College of Agriculture and Life Sciences], and the
   Macromolecular Interfaces with Life Sciences (MILES) Integrative
   Graduate Education and Research Traineeship (IGERT) of the National
   Science Foundation under Agreement No. DGE-0333378. The authors thank
   Kimberly A. Negrin, Julie Franklin, and Louisa Gay for data collection,
   Louisa Gay and James Martin for technical laboratory expertise, and
   Stephen R. Were for statistical consultation and analyzes.
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NR 29
TC 69
Z9 76
U1 0
U2 41
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0891-6640
J9 J VET INTERN MED
JI J. Vet. Intern. Med.
PD MAY-JUN
PY 2013
VL 27
IS 3
BP 576
EP 582
DI 10.1111/jvim.12056
PG 7
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA 140MO
UT WOS:000318658400025
PM 23517373
DA 2025-06-11
ER

PT J
AU Gupta, H
   Min, BH
   Ganesan, R
   Gebru, YA
   Sharma, SP
   Park, E
   Won, SM
   Jeong, JJ
   Lee, SB
   Cha, MG
   Kwon, GH
   Jeong, MK
   Hyun, JY
   Eom, JA
   Park, HJ
   Yoon, SJ
   Choi, MR
   Kim, DJ
   Suk, KT
AF Gupta, Haripriya
   Min, Byeong-Hyun
   Ganesan, Raja
   Gebru, Yoseph Asmelash
   Sharma, Satya Priya
   Park, Eunju
   Won, Sung-Min
   Jeong, Jin-Ju
   Lee, Su-Been
   Cha, Min-Gi
   Kwon, Goo-Hyun
   Jeong, Min-Kyo
   Hyun, Ji-Ye
   Eom, Jung-A
   Park, Hee-Jin
   Yoon, Sang-Jun
   Choi, Mi-Ran
   Kim, Dong-Joon
   Suk, Ki-Tae
TI Gut Microbiome in Non-Alcoholic Fatty Liver Disease: From Mechanisms to
   Therapeutic Role
SO BIOMEDICINES
LA English
DT Article
DE microbiota; NAFLD; microbial functions; microbiota-based approach
ID DE-NOVO LIPOGENESIS; INSULIN-RESISTANCE; OXIDATIVE STRESS; HEPATIC
   STEATOSIS; TRYPTOPHAN-METABOLITES; ADIPOSE-TISSUE; SYNBIOTIC
   SUPPLEMENTATION; INTESTINAL MICROBIOTA; HIGH-CARBOHYDRATE; BARRIER
   FUNCTION
AB Non-alcoholic fatty liver disease (NAFLD) is considered to be a significant health threat globally, and has attracted growing concern in the research field of liver diseases. NAFLD comprises multifarious fatty degenerative disorders in the liver, including simple steatosis, steatohepatitis and fibrosis. The fundamental pathophysiology of NAFLD is complex and multifactor-driven. In addition to viruses, metabolic syndrome and alcohol, evidence has recently indicated that the microbiome is related to the development and progression of NAFLD. In this review, we summarize the possible microbiota-based therapeutic approaches and highlight the importance of establishing the diagnosis of NAFLD through the different spectra of the disease via the gut-liver axis.
C1 [Gupta, Haripriya; Min, Byeong-Hyun; Ganesan, Raja; Gebru, Yoseph Asmelash; Sharma, Satya Priya; Park, Eunju; Won, Sung-Min; Jeong, Jin-Ju; Lee, Su-Been; Cha, Min-Gi; Kwon, Goo-Hyun; Jeong, Min-Kyo; Hyun, Ji-Ye; Eom, Jung-A; Park, Hee-Jin; Yoon, Sang-Jun; Choi, Mi-Ran; Kim, Dong-Joon; Suk, Ki-Tae] Hallym Univ, Coll Med, Inst Liver & Digest Dis, Chunchon 24252, South Korea.
C3 Hallym University
RP Suk, KT (corresponding author), Hallym Univ, Coll Med, Inst Liver & Digest Dis, Chunchon 24252, South Korea.
EM haripriya.gupta@hallym.ac.kr; 43568@hallym.ac.kr; rg@hallym.ac.kr;
   yoseph@hallym.ac.kr; satyapriya83@hallym.ac.kr; epark312@hallym.ac.kr;
   lionbanana@hallym.ac.kr; jj_jeong@hallym.ac.kr; qlstn5549@gmail.com;
   qjarlf987@naver.com; ninetjd@naver.com; 43916@hallym.ac.kr;
   43566@hallym.ac.kr; 43563@hallym.ac.kr; 43565@hallym.ac.kr;
   ysjtlhuman@gmail.com; choimr@hallym.ac.kr; djkim@hallym.ac.kr;
   ktsuk@hallym.ac.kr
RI won, sungmin/AAH-8401-2021; Kim, Hee Man/AAF-4253-2020; Ganesan,
   Raja/AAW-3703-2021; Gupta, Haripriya/ADF-9486-2022
OI Yoon, Sang Jun/0000-0003-4712-6359; Sharma,
   SatyaPriya/0000-0001-5994-8179; Ganesan, Raja/0000-0003-3060-6217; Kim,
   Dong Joon/0000-0002-5792-1500; Suk, Ki Tae/0000-0002-9206-9245; Gupta,
   Haripriya/0000-0002-6008-1143; Jeong, Jin-Ju/0000-0001-5728-9886
FU Hallym University Research Fund; Basic Science Research Program through
   the National Research Foundation of Korea - Ministry of Education,
   Science and Technology [NRF-2018M3A9F3020956, NRF-2019R1I1A3A01060447,
   NRF2020R1I1A3073530, NRF-2020R1A6A1A03043026]
FX This research was supported by the Hallym University Research Fund, the
   Basic Science Research Program through the National Research Foundation
   of Korea, funded by the Ministry of Education, Science and Technology
   (NRF-2018M3A9F3020956, NRF-2019R1I1A3A01060447, NRF2020R1I1A3073530 and
   NRF-2020R1A6A1A03043026).
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NR 184
TC 29
Z9 30
U1 3
U2 21
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2227-9059
J9 BIOMEDICINES
JI Biomedicines
PD MAR
PY 2022
VL 10
IS 3
AR 550
DI 10.3390/biomedicines10030550
PG 24
WC Biochemistry & Molecular Biology; Medicine, Research & Experimental;
   Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Research & Experimental Medicine;
   Pharmacology & Pharmacy
GA 0D2SX
UT WOS:000775851800001
PM 35327352
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Loehfelm, A
   Boucsein, A
   Pretz, D
   Tups, A
AF Loehfelm, Aline
   Boucsein, Alisa
   Pretz, Dominik
   Tups, Alexander
TI Timing Matters: Circadian Effects on Energy Homeostasis and Alzheimer's
   Disease
SO TRENDS IN ENDOCRINOLOGY AND METABOLISM
LA English
DT Review
ID GROWTH-FACTOR EXPRESSION; BETA/NF-KAPPA-B; INSULIN-RESISTANCE;
   SUPRACHIASMATIC NUCLEUS; INTRANASAL INSULIN; OXIDATIVE STRESS; IMPROVE
   SLEEP; BODY-WEIGHT; MOUSE MODEL; FOOD-INTAKE
AB Metabolic syndrome and Alzheimer's disease (AD) are two major health issues in modern society causing an extraordinary financial burden for the global healthcare systems. A tight link between the pathologies of obesity and type 2 diabetes (T2D), and more recently between T2D and AD, has been discovered. Furthermore, in recent years it has become apparent that the circadian clock has an important function in controlling metabolism. This review integrates the role of the circadian clock in the development of these metabolic derangements and vice versa. Common features such as central insulin resistance, altered glycogen synthase kinase 3 beta (GSK3 beta) signalling, and central inflammation are discussed, and therapeutic interventions targeting those mechanisms are mentioned briefly.
C1 [Loehfelm, Aline; Boucsein, Alisa; Pretz, Dominik; Tups, Alexander] Univ Otago, Sch Med Sci, Dept Physiol, Ctr Neuroendocrinol, Dunedin 9054, New Zealand.
   [Loehfelm, Aline; Boucsein, Alisa; Pretz, Dominik; Tups, Alexander] Univ Otago, Sch Med Sci, Dept Physiol, Brain Hlth Res Ctr, Dunedin 9054, New Zealand.
C3 University of Otago; University of Otago
RP Tups, A (corresponding author), Univ Otago, Sch Med Sci, Dept Physiol, Ctr Neuroendocrinol, Dunedin 9054, New Zealand.; Tups, A (corresponding author), Univ Otago, Sch Med Sci, Dept Physiol, Brain Hlth Res Ctr, Dunedin 9054, New Zealand.
EM alexander.tups@otago.ac.nz
RI Boucsein, Alisa/S-9938-2019
OI Boucsein, Alisa/0000-0002-6266-8802
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NR 96
TC 8
Z9 8
U1 1
U2 17
PU ELSEVIER SCIENCE LONDON
PI LONDON
PA 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND
SN 1043-2760
EI 1879-3061
J9 TRENDS ENDOCRIN MET
JI Trends Endocrinol. Metab.
PD FEB
PY 2019
VL 30
IS 2
BP 132
EP 143
DI 10.1016/j.tem.2018.12.001
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA HI4EA
UT WOS:000456402700006
PM 30594436
DA 2025-06-11
ER

PT J
AU Stewart, MS
   Heerwagen, MJR
   Friedman, JE
AF Stewart, Michael S.
   Heerwagen, Margaret J. R.
   Friedman, Jacob E.
TI Developmental Programming of Pediatric Nonalcoholic Fatty Liver Disease:
   Redefining the"First Hit"
SO CLINICAL OBSTETRICS AND GYNECOLOGY
LA English
DT Article
DE NAFLD; nonalcoholic steatohepatitis; pediatric NASH; maternal obesity;
   fetal programming; mitochondrial dysfunction; lipotoxicity; sirtuins
ID DEPENDENT DIABETES-MELLITUS; BODY-MASS INDEX; INSULIN-RESISTANCE;
   MATERNAL OBESITY; METABOLIC-SYNDROME; HEPATIC STEATOSIS; MITOCHONDRIAL
   DYSFUNCTION; ALANINE AMINOTRANSFERASE; INTESTINAL MICROBIOTA;
   NONHUMAN-PRIMATES
AB The incidence of pediatric nonalcoholic fatty liver disease has increased dramatically, and growing evidence indicates that the pathophysiology may be unique from the adult form, suggesting a role for early-life events. Recent radiologic techniques have now demonstrated that maternal obesity contributes to hepatic fat storage in newborn infants. In this review, we will explore how maternal obesity and a hyperlipidemic environment can initiate liver histopathogenesis in utero, including steatosis, mitochondrial dysfunction, oxidative stress, and inflammatory priming. Thus, early exposure to excess lipids may represent the first hit for the fetal liver, placing it on a trajectory toward future metabolic disease.
C1 [Stewart, Michael S.; Heerwagen, Margaret J. R.; Friedman, Jacob E.] Univ Colorado, Dept Pediat, Div Neonatol, Sch Med, Aurora, CO USA.
   [Friedman, Jacob E.] Univ Colorado, Dept Biochem & Mol Genet, Sch Med, Aurora, CO USA.
C3 University of Colorado System; University of Colorado Anschutz Medical
   Campus; University of Colorado System; University of Colorado Anschutz
   Medical Campus
RP Friedman, JE (corresponding author), Univ Colorado, Dept Pediat, Div Neonatol, Sch Med, Anschutz Med Campus,MS 8106,12801 E 17th Ave, Aurora, CO USA.
EM jed.friedman@ucdenver.edu
FU NIH/NICHD [T32 HD007186]; NIH/CTSI [TL1-RR-025778, AHA-11PRE502001,
   NIH-R24-DK090964, NIH-RO1-DK077630, NIH-RO1DK078645, NIH-R29-DK088324]
FX Supported by NIH/NICHD T32 HD007186 (M.S.S.), NIH/CTSI TL1-RR-025778
   (M.J.R.H.), AHA-11PRE502001(M.J.R.H.),NIH-R24-DK090964 (J.E.F.),
   NIH-RO1-DK077630 (J.E.F.), NIH-RO1DK078645 (J.E.F.), and
   NIH-R29-DK088324 (J.E.F.).
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NR 109
TC 32
Z9 36
U1 0
U2 16
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0009-9201
EI 1532-5520
J9 CLIN OBSTET GYNECOL
JI Clin. Obstet. Gynecol.
PD SEP
PY 2013
VL 56
IS 3
BP 577
EP 590
DI 10.1097/GRF.0b013e3182a09760
PG 14
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA 202PO
UT WOS:000323230700019
PM 23835912
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Restivo, I
   Attanzio, A
   Tesoriere, L
   Allegra, M
   Garcia-Llatas, G
   Cilla, A
AF Restivo, Ignazio
   Attanzio, Alessandro
   Tesoriere, Luisa
   Allegra, Mario
   Garcia-Llatas, Guadalupe
   Cilla, Antonio
TI Anti-Eryptotic Activity of Food-Derived Phytochemicals and Natural
   Compounds
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE eryptosis; phytochemicals; food-derived compound; red blood cells;
   phenolic compounds; alkaloids; oxidative stress
ID SUICIDAL ERYTHROCYTE DEATH; PROGRAMMED CELL-DEATH; PHOSPHATIDYLSERINE
   EXPOSURE; HYDROGEN-PEROXIDE; DYNAMIC ADHESION; ANEMIA; PLATELET; SERUM;
   EXTERNALIZATION; ACTIVATION
AB Human red blood cells (RBCs), senescent or damaged due to particular stress, can be removed by programmed suicidal death, a process called eryptosis. There are various molecular mechanisms underlying eryptosis. The most frequent is the increase in the cytoplasmic concentration of Ca2+ ions, later exposure of erythrocytes to oxidative stress, hyperosmotic shock, ceramide formation, stimulation of caspases, and energy depletion. Phosphatidylserine (PS) exposed by eryptotic RBCs due to interaction with endothelial CXC-Motiv-Chemokin-16/Scavenger-receptor, causes the RBCs to adhere to vascular wall with consequent damage to the microcirculation. Eryptosis can be triggered by various xenobiotics and endogenous molecules, such as high cholesterol levels. The possible diseases associated with eryptosis are various, including anemia, chronic kidney disease, liver failure, diabetes, hypertension, heart failure, thrombosis, obesity, metabolic syndrome, arthritis, and lupus. This review addresses and collates the existing ex vivo and animal studies on the inhibition of eryptosis by food-derived phytochemicals and natural compounds including phenolic compounds (PC), alkaloids, and other substances that could be a therapeutic and/or co-adjuvant option in eryptotic-driven disorders, especially if they are introduced through the diet.
C1 [Restivo, Ignazio; Attanzio, Alessandro; Tesoriere, Luisa; Allegra, Mario] Univ Palermo, Dept Biol Chem & Pharmaceut Sci & Technol, Via Archirafi 28, I-90123 Palermo, Italy.
   [Garcia-Llatas, Guadalupe; Cilla, Antonio] Univ Valencia, Fac Pharm, Nutr & Food Sci Area, Avda Vicente Andres Estelles S-N, Burjassot 46100, Spain.
C3 University of Palermo; University of Valencia
RP Attanzio, A (corresponding author), Univ Palermo, Dept Biol Chem & Pharmaceut Sci & Technol, Via Archirafi 28, I-90123 Palermo, Italy.
EM ignazio.restivo@unipa.it; alessandro.attanzio@unipa.it;
   luisa.tesoriere@unipa.it; mario.allegra@unipa.it;
   guadalupe.garcia@uv.es; antonio.cilla@uv.es
RI Restivo, Ignazio/AAW-8282-2020; Allegra, Mario/AAG-3256-2019; Cilla,
   Antonio/K-8118-2014; Garcia-Llatas, Guadalupe/I-8772-2012
OI Allegra, Mario/0000-0002-5846-1868; RESTIVO,
   IGNAZIO/0000-0003-1833-2356; tesoriere, Luisa/0000-0002-7980-7530;
   Cilla, Antonio/0000-0001-6532-9032; Garcia-Llatas,
   Guadalupe/0000-0002-4681-4208
FU MCIN/AEI [PID2019-104167RB-I00]; EUROPEAN UNION 2014-2020 PON RICERCA E
   INNOVAZIONE GRANT FROM THE ITALIAN MINISTRY OF EDUCATION, UNIVERSITY AND
   RESEARCH [ARS01_00432/]
FX Grant PID2019-104167RB-I00 funded by MCIN/AEI/10.13039/501100011033;
   EUROPEAN UNION 2014-2020 PON RICERCA E INNOVAZIONE GRANT FROM THE
   ITALIAN MINISTRY OF EDUCATION, UNIVERSITY AND RESEARCH, ENTITLED
   "PROGEMA-PROCESSI GREEN PER L'ESTRAZIONE DI PRINCIPI ATTIVI E LA
   DEPURAZIONE DI MATRICI DI SCARTO E NON" (ARS01_00432/).
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NR 77
TC 9
Z9 9
U1 0
U2 4
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD MAR
PY 2022
VL 23
IS 6
AR 3019
DI 10.3390/ijms23063019
PG 15
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 0C6SO
UT WOS:000775441000001
PM 35328440
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Reyes-Farias, M
   Vasquez, K
   Fuentes, E
   Ovalle-Marin, A
   Parra-Ruiz, C
   Zamora, O
   Pino, MT
   Quitral, V
   Jimenez, P
   Garcia, L
   Garcia-Diaz, DF
AF Reyes-Farias, M.
   Vasquez, K.
   Fuentes, E.
   Ovalle-Marin, A.
   Parra-Ruiz, C.
   Zamora, O.
   Pino, M. T.
   Quitral, V.
   Jimenez, P.
   Garcia, L.
   Garcia-Diaz, D. F.
TI Extracts of Chilean native fruits inhibit oxidative stress, inflammation
   and insulin-resistance linked to the pathogenic interaction between
   adipocytes and macrophages
SO JOURNAL OF FUNCTIONAL FOODS
LA English
DT Article
DE Obesity; Adipocytes; Macrophages; Inflammation; Oxidative stress;
   Insulin-resistance
ID NF-KAPPA-B; CHILENSIS MOL. STUNTZ; ADIPOSE-TISSUE; METABOLIC SYNDROME;
   PI3K ACTIVATION; TNF-ALPHA; OBESITY; EXPRESSION; ANTHOCYANINS;
   DELPHINIDIN
AB Obesity-associated insulin-resistance is set by a chronic inflammatory state established in the adipose tissue. Chilean native fruits calafate (CA) and maqui (MA) berries present remarkable anti-inflammatory features. Here, we evaluated antioxidant, anti-inflammatory and insulin-sensitizer effects of these fruits in an in vitro inflammatory setting. Differentiated 3T3-L1 cells exposed to conditioned media (CM) from activated macrophages were treated with CA and MA extracts. MA increased metalloproteinase (MMP)-2 activity on day 3, and both CA and MA modulated MMP-9 activity on day 10 of differentiation. In differentiated CM-treated 3T3-L1, extracts increased GSH levels and GSH/GSSG ratio, CA and MA prevented caspase-3 induction, and MA decreased MCP-1, while CA increased IL-6 gene expressions. Finally, MA reverted CM specific IRS-1 phosphorylation, and CA improved insulin stimulated glucose uptake. Thus, treatments with extracts of Chilean native fruits were able to block the development of oxidative stress, inflammation and insulin-resistance in vitro. (C) 2016 Elsevier Ltd. All rights reserved.
C1 [Reyes-Farias, M.; Vasquez, K.; Fuentes, E.; Ovalle-Marin, A.; Parra-Ruiz, C.; Quitral, V.; Jimenez, P.; Garcia-Diaz, D. F.] Univ Chile, Sch Med, Dept Nutr, Independencia 1027, Santiago 8389100, Chile.
   [Zamora, O.; Pino, M. T.] Inst Invest Agr, Santiago, Chile.
   [Garcia, L.] Univ Chile, Dept Biochem & Mol Biol, Fac Chem & Pharmaceut Sci, Adv Ctr Chron Dis ACCDiS, Santiago, Chile.
C3 Universidad de Chile; Universidad de Chile
RP Garcia-Diaz, DF (corresponding author), Univ Chile, Sch Med, Dept Nutr, Independencia 1027, Santiago 8389100, Chile.
EM dgarcia@med.uchile.cl
RI Jiménez, Paula/H-3136-2018; Reyes Farias, Marjorie/AGP-5221-2022;
   QUITRAL, VILMA/GQA-9465-2022; Garcia, Diego/AGH-4056-2022
OI Garcia-Diaz, Diego/0000-0002-7551-0553; Quitral,
   Vilma/0000-0001-7477-4824; Parra Ruiz, Claudia/0000-0003-0264-6457;
   Reyes-Farias, Marjorie/0000-0001-9179-7251
FU FONDECYT grant [11110219]; FONDAP grant [15130011]
FX The authors thank Dr. Cecilia Rojas (Laboratory of Cellular and
   Molecular Biology, INTA, University of Chile) and Dr. Juan Diego Maya
   (Laboratory of Biochemistry, Metabolism and Drug Resistance, ICBM,
   University of Chile) for kindly giving us 3T3 L1 and RAW264.7 vials,
   respectively; and Dr. Pablo Quintero for his English writing
   corrections. This work was supported by the FONDECYT grant 11110219
   (CONICYT, Chile) and FONDAP grant 15130011, Advanced Center for Chronic
   Diseases (ACCDiS).
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NR 65
TC 27
Z9 27
U1 0
U2 50
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1756-4646
EI 2214-9414
J9 J FUNCT FOODS
JI J. Funct. Food.
PD DEC
PY 2016
VL 27
BP 69
EP 83
DI 10.1016/j.jff.2016.08.052
PG 15
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA EF2UB
UT WOS:000390180000006
DA 2025-06-11
ER

PT J
AU Wang, WQ
   Zhang, HF
   Gao, GX
   Bai, QX
   Li, R
   Wang, XM
AF Wang, W. -Q.
   Zhang, H. -F.
   Gao, G. -X.
   Bai, Q. -X.
   Li, R.
   Wang, X. -M.
TI Adiponectin Inhibits Hyperlipidemia-Induced Platelet Aggregation
   via Attenuating Oxidative/Nitrative Stress
SO PHYSIOLOGICAL RESEARCH
LA English
DT Article
DE Adiponectin; Platelet; Aggregation; Hyperlipidemia
ID NITRIC-OXIDE SYNTHASE; DEPENDENT PROTEIN-KINASE; METABOLIC SYNDROME;
   SUPEROXIDE; ACTIVATION; PEROXYNITRITE; EXPRESSION
AB Adiponectin acts as an endogenous antithrombotic factor. However, the mechanisms underlying the inhibition of platelet aggregation by adiponectin still remain elusive. The present study was designed to test whether adiponectin inhibits platelet aggregation by attenuation of oxidative/nitrative stress. Adult rats were fed a regular or high-fat diet for 14 weeks. The platelet was immediately separated and stimulated with recombinant full-length adiponectin (rAPN) or not. The platelet aggregation, nitric oxide (NO) and superoxide production, endothelial nitric oxide synthase (eNOS)/inducible NOS (iNOS) expression, and antioxidant capacity were determined. Treatment with rAPN inhibited hyperlipidemia-induced platelet aggregation (P<0.05). Interestingly, total NO, a crucial molecule depressing platelet aggregation and thrombus formation, was significantly reduced, rather than increased in rAPN-treated platelets. Treatment with rAPN markedly decreased superoxide production (-62 %, P<0.05) and enhanced antioxidant capacity (+38 %, P<0.05) in hyperlipidemic platelets. Hyperlipidemia-induced reduced eNOS phosphorylation and increased iNOS expression were significantly reversed following rAPN treatment (P<0.05, P<0.01, respectively). Taken together, these data suggest that adiponectin is an adipokine that suppresses platelet aggregation by enhancing eNOS activation and attenuating oxidative/nitrative stress including blocking iNOS expression and superoxide production.
C1 [Li, R.; Wang, X. -M.] Fourth Mil Med Univ, Dept Geriatr, Xijing Hosp, 15 Changlexi Rd, Xian 710032, Peoples R China.
   [Zhang, H. -F.] Fourth Mil Med Univ, Dept Physiol, Xijing Hosp, Xian 710032, Peoples R China.
   [Wang, W. -Q.; Gao, G. -X.; Bai, Q. -X.] Fourth Mil Med Univ, Tangdu Hosp, Dept Hematol, Xian 710032, Peoples R China.
C3 Air Force Medical University; Air Force Medical University; Air Force
   Medical University
RP Li, R (corresponding author), Fourth Mil Med Univ, Dept Geriatr, Xijing Hosp, 15 Changlexi Rd, Xian 710032, Peoples R China.
EM rongli.li09@gmail.com; xmwang@fmmu.edu.cn
OI Wang, Xiaoming/0000-0002-9671-6358; Zhang, Haifeng/0000-0003-1938-3796
FU National Natural Science Foundation of China [30700308]
FX This research was supported by the following grants: National Natural
   Science Foundation of China (No. 30700308 to R. Li).
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NR 32
TC 31
Z9 35
U1 1
U2 15
PU ACAD SCIENCES CZECH REPUBLIC, INST PHYSIOLOGY
PI PRAGUE 4
PA VIDENSKA 1083, PRAGUE 4 142 20, CZECH REPUBLIC
SN 0862-8408
EI 1802-9973
J9 PHYSIOL RES
JI Physiol. Res.
PY 2011
VL 60
IS 2
BP 347
EP 354
DI 10.33549/physiolres.932044
PG 8
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA 771KF
UT WOS:000291154900018
PM 21114366
OA gold
DA 2025-06-11
ER

PT J
AU Kountouras, J
   Boziki, M
   Kazakos, E
   Theotokis, P
   Kesidou, E
   Nella, M
   Bakirtzis, C
   Karafoulidou, E
   Vardaka, E
   Mouratidou, MC
   Kyrailidi, F
   Tzitiridou-Chatzopoulou, M
   Orovou, E
   Giartza-Taxidou, E
   Deretzi, G
   Grigoriadis, N
   Doulberis, M
AF Kountouras, Jannis
   Boziki, Marina
   Kazakos, Evangelos
   Theotokis, Paschalis
   Kesidou, Evangelia
   Nella, Maria
   Bakirtzis, Christos
   Karafoulidou, Eleni
   Vardaka, Elisabeth
   Mouratidou, Maria C.
   Kyrailidi, Foteini
   Tzitiridou-Chatzopoulou, Maria
   Orovou, Eirini
   Giartza-Taxidou, Evaggelia
   Deretzi, Georgia
   Grigoriadis, Nikolaos
   Doulberis, Michael
TI Impact of Helicobacter pylori and metabolic syndrome on mast cell
   activation-related pathophysiology and neurodegeneration
SO NEUROCHEMISTRY INTERNATIONAL
LA English
DT Article
DE Helicobacter pylori; Metabolic syndrome; Mast cell activation;
   Cardio-cerebrovascular diseases; Brain pathologies; Neurodegeneration
ID CENTRAL-NERVOUS-SYSTEM; FATTY LIVER-DISEASE; BRAIN INSULIN-RESISTANCE;
   COGNITIVE IMPAIRMENT; AMYLOID-BETA; ATRIAL-FIBRILLATION;
   ALZHEIMERS-DISEASE; PLASMA HOMOCYSTEINE; ARTERIAL STIFFNESS;
   PARKINSONS-DISEASE
AB Both Helicobacter pylori (H. pylori) infection and metabolic syndrome (MetS) are highly prevalent worldwide. The emergence of relevant research suggesting a pathogenic linkage between H. pylori infection and MetS-related cardio-cerebrovascular diseases and neurodegenerative disorders, particularly through mechanisms involving brain pericyte deficiency, hyperhomocysteinemia, hyperfibrinogenemia, elevated lipoprotein-a, galectin-3 overexpression, atrial fibrillation, and gut dysbiosis, has raised stimulating questions regarding their pathophysiology and its translational implications for clinicians. An additional stimulating aspect refers to H. pylori and MetS-related activation of innate immune cells, mast cells (MC), which is an important, often early, event in systemic inflammatory pathologies and related brain disorders. Synoptically, MC degranulation may play a role in the pathogenesis of H. pylori and MetS-related obesity, adipokine effects, dyslipidemia, diabetes mellitus, insulin resistance, arterial hypertension, vascular dysfunction and arterial stiffness, an early indicator of atherosclerosis associated with cardio-cerebrovascular and neurodegenerative disorders. Meningeal MC can be activated by triggers including stress and toxins resulting in vascular changes and neurodegeneration. Likewise, H. pylori and MetS-related MC activation is linked with: (a) vasculitis and thromboembolic events that increase the risk of cardio-cerebrovascular and neurodegenerative disorders, and (b) gut dysbiosis-associated neurodegeneration, whereas modulation of gut microbiota and MC activation may promote neuroprotection. This narrative review investigates the intricate relationship between H. pylori infection, MetS, MC activation, and their collective impact on pathophysiological processes linked to neurodegeneration. Through a comprehensive search of current literature, we elucidate the mechanisms through which H. pylori and MetS contribute to MC activation, subsequently triggering cascades of inflammatory responses. This highlights the role of MC as key mediators in the pathogenesis of cardio-cerebrovascular and neurodegenerative disorders, emphasizing their involvement in neuroinflammation, vascular dysfunction and, ultimately, neuronal damage. Although further research is warranted, we provide a novel perspective on the pathophysiology and management of brain disorders by exploring potential therapeutic strategies targeting H. pylori eradication, MetS management, and modulation of MC to mitigate neurodegeneration risk while promoting neuroprotection.
C1 [Kountouras, Jannis; Kazakos, Evangelos; Vardaka, Elisabeth; Mouratidou, Maria C.; Kyrailidi, Foteini; Tzitiridou-Chatzopoulou, Maria; Orovou, Eirini; Giartza-Taxidou, Evaggelia; Deretzi, Georgia; Doulberis, Michael] Aristotle Univ Thessaloniki, Ippokrat Hosp, Sch Med, Med Clin 2, Thessaloniki 54642, Macedonia, Greece.
   [Boziki, Marina; Theotokis, Paschalis; Kesidou, Evangelia; Nella, Maria; Bakirtzis, Christos; Karafoulidou, Eleni; Grigoriadis, Nikolaos] AHEPA Univ Hosp, Aristotle Univ Thessaloniki, Lab Expt Neurol & Neuroimmunol, Thessaloniki, Macedonia, Greece.
   [Boziki, Marina; Theotokis, Paschalis; Kesidou, Evangelia; Nella, Maria; Bakirtzis, Christos; Karafoulidou, Eleni; Tzitiridou-Chatzopoulou, Maria; Grigoriadis, Nikolaos] Aristotle Univ Thessaloniki, AHEPA Univ Hosp, Multiple Sclerosis Ctr, Dept Neurol 2, Thessaloniki, Macedonia, Greece.
   [Kazakos, Evangelos; Orovou, Eirini] Univ West Macedonia, Sch Healthcare Sci, Midwifery Dept, Kozani 50100, Macedonia, Greece.
   [Vardaka, Elisabeth] Int Hellen Univ, Sch Hlth Sci, Dept Nutr Sci & Dietet, Alexander Campus, Thermi 57400, Macedonia, Greece.
   [Deretzi, Georgia] Papageorgiou Gen Hosp, Dept Neurol, Thessaloniki, Macedonia, Greece.
   [Doulberis, Michael] Gastroklinik, CH-8810 Horgen, Switzerland.
   [Doulberis, Michael] Med Univ Dept, Div Gastroenterol & Hepatol, Kantonsspital Aarau, CH-5001 Aarau, Switzerland.
   [Kountouras, Jannis] Aristotle Univ Thessaloniki, Ippokrat Hosp, Dept Internal Med, Med Clin 2, Thessaloniki 54642, Macedonia, Greece.
C3 Aristotle University of Thessaloniki; Aristotle University of
   Thessaloniki; Ahepa University Hospital; Aristotle University of
   Thessaloniki; Ahepa University Hospital; International Hellenic
   University; Papageorgiou Hospital; Kantonsspital Aarau AG (KSA);
   Aristotle University of Thessaloniki
RP Kountouras, J (corresponding author), Aristotle Univ Thessaloniki, Ippokrat Hosp, Dept Internal Med, Med Clin 2, Thessaloniki 54642, Macedonia, Greece.
EM jannis@auth.gr
RI Bakirtzis, Christos/AAV-9163-2020; Orovou, Eirini/AAH-8721-2021; Boziki,
   Marina/ACF-8768-2022; Theotokis, Paschalis/AAU-8003-2021; Doulberis MD,
   DVM, PhD, FEBGH, Michael/Y-5118-2018; Tzitiridou, Dr.
   Maria/KHW-8314-2024
OI Theotokis, Paschalis/0000-0001-8607-6695; Tzitiridou, Dr.
   Maria/0000-0001-6051-0860
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NR 298
TC 9
Z9 9
U1 5
U2 8
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0197-0186
EI 1872-9754
J9 NEUROCHEM INT
JI Neurochem. Int.
PD MAY
PY 2024
VL 175
AR 105724
DI 10.1016/j.neuint.2024.105724
EA MAR 2024
PG 16
WC Biochemistry & Molecular Biology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Neurosciences & Neurology
GA QV5P3
UT WOS:001223660600001
PM 38508416
DA 2025-06-11
ER

PT J
AU Kitagawa, R
   Kon, K
   Uchiyama, A
   Arai, K
   Yamashina, S
   Kuwahara-Arai, K
   Kirikae, T
   Ueno, T
   Ikejima, K
AF Kitagawa, Ryuta
   Kon, Kazuyoshi
   Uchiyama, Akira
   Arai, Kumiko
   Yamashina, Shunhei
   Kuwahara-Arai, Kyoko
   Kirikae, Teruo
   Ueno, Takashi
   Ikejima, Kenichi
TI Rifaximin prevents ethanol-induced liver injury in obese
   KK-A<SUP>y</SUP> mice through modulation of small intestinal microbiota
   signature
SO AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
LA English
DT Article
DE alcoholic liver disease; dysbiosis; metabolic syndrome;
   pathogen-associated molecular patterns; toll-like receptor
ID ALCOHOLIC LIVER; GUT MICROBIOTA; DISEASE PATHOGENESIS; REDUCES
   ENDOTOXEMIA; MOUSE MODEL; INFLAMMATION; INDUCTION; MECHANISM;
   STEATOHEPATITIS; PERMEABILITY
AB Exacerbation of alcoholic hepatitis (AII) with comorbid metabolic syndrome is an emerging clinical problem, where microbiota plays a profound role in the pathogenesis. Here, we investigated the effect of rifaximin (RFX) on liver injury following chronic-binge ethanol (EtOH) administration in KK-A(y) mice, a rodent model of metabolic syndrome. Female, 8-wk-old KK-A(y) mice were fed Lieber-DeCarli diet (5% EtOH) for 10 days, following a single EtOH gavage (4 g/kg body wt). Some mice were given RFX (0.1 g/L, in liquid diet) orally. Small intestinal contents were collected from mice without binge. Intestinal microbiota was quantified using aerobic and anaerobic culturing techniques and further analyzed by 16S rRNA sequencing in detail. EtOH feeding/binge caused hepatic steatosis, oxidative stress, and induction of inflammatory cytokines in KK-A(y) mice, which were markedly prevented by RFX treatment. Hepatic mRNA levels for cluster of differentiation 14, Toll-like receptor (TLR) 4. TLR2, and NADPH oxidase 2 were increased following EtOH feeding/binge. and administration of RFX completely suppressed their increase. The net amount of small intestinal bacteria was increased over threefold after chronic EtOH feeding as expected; however, RFX did not prevent this net increase. Intriguingly, the profile of small intestinal microbiota was dramatically changed following EtOH feeding in the order level, where the Erysipelotrichales predominated in the relative abundance. In sharp contrast, RFX drastically blunted the EtOH-induced increases in the Erysipelotrichales almost completely, with increased proportion of the Bacteroidales. In conclusion, RFX prevents AH through modulation of small intestinal microbiota/innate immune responses in obese KK-A(y) mice.
   NEW & NOTEWORTHY Here we demonstrated that rifaximin (RFX) prevents chronic-binge ethanol (EtOH)-induced steatohepatitis in KK-A(y) mice. Chronic EtOH feeding caused small intestinal bacterial overgrowth, with drastic alteration in the microbiota profile predominating the order Erysipelotrichales. RFX minimized this EtOH induction in Erysipelotrichales with substitutive increases in Bacteroidales. RFX also prevented EtOH-induced increases in portal lipopolysaccharide, and hepatic cluster of differentiation 14, toll-like receptor (TLR) 2, and TLR4 mRNA levels, suggesting the potential involvement of microbiota-related innate immune responses.
C1 [Kitagawa, Ryuta; Kon, Kazuyoshi; Uchiyama, Akira; Arai, Kumiko; Yamashina, Shunhei; Ikejima, Kenichi] Juntendo Univ, Dept Gastroenterol, Grad Sch Med, Tokyo, Japan.
   [Kuwahara-Arai, Kyoko; Kirikae, Teruo] Juntendo Univ, Dept Microbiol, Grad Sch Med, Tokyo, Japan.
   [Ueno, Takashi] Juntendo Univ, Lab Prote & Med Sci, Grad Sch Med, Res Support Ctr, Tokyo, Japan.
C3 Juntendo University; Juntendo University; Juntendo University
RP Kon, K (corresponding author), 2-1-1 Hongo,Bunkyo Ku, Tokyo 1138421, Japan.
EM kazukon@juntendo.ac.jp
RI Kon, Kazuyoshi/AAV-7832-2020
OI Ikejima, Kenichi/0000-0002-2657-0840
FU Japan Society for the Promotion of Science [17K09440, 15K09023];
   Grants-in-Aid for Scientific Research [17K09440, 15K09023] Funding
   Source: KAKEN
FX This work was supported in part by Japan Society for the Promotion of
   Science Grants-in-Aid for Scientific Research (KAKENHI) (17K09440 to K.
   Kon and 15K09023 to K. Ikejima).
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NR 63
TC 24
Z9 26
U1 0
U2 12
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0193-1857
EI 1522-1547
J9 AM J PHYSIOL-GASTR L
JI Am. J. Physiol.-Gastroint. Liver Physiol.
PD NOV
PY 2019
VL 317
IS 5
BP G707
EP G715
DI 10.1152/ajpgi.00372.2018
PG 9
WC Gastroenterology & Hepatology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Physiology
GA JP6WN
UT WOS:000498403600015
PM 31509430
OA Bronze
DA 2025-06-11
ER

PT J
AU Vekic, J
   Zeljkovic, A
   Stefanovic, A
   Giglio, RV
   Ciaccio, M
   Rizzo, M
AF Vekic, Jelena
   Zeljkovic, Aleksandra
   Stefanovic, Aleksandra
   Giglio, Rosaria Vincenza
   Ciaccio, Marcello
   Rizzo, Manfredi
TI Diabetes and Colorectal Cancer Risk: A New Look at Molecular Mechanisms
   and Potential Role of Novel Antidiabetic Agents
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE insulin resistance; hyperglycemia; oxidative stress; inflammation; small
   dense LDL; glucagon-like peptide-1 receptor agonists
ID INCRETIN-BASED THERAPIES; HIGH-DENSITY-LIPOPROTEIN; GLYCATION
   END-PRODUCTS; INSULIN-RESISTANCE; OXIDATIVE STRESS; COLON
   CARCINOGENESIS; LIPID-PEROXIDATION; METABOLIC SYNDROME; ALDOSE
   REDUCTASE; LIFE-STYLE
AB Epidemiological data have demonstrated a significant association between the presence of type 2 diabetes mellitus (T2DM) and the development of colorectal cancer (CRC). Chronic hyperglycemia, insulin resistance, oxidative stress, and inflammation, the processes inherent to T2DM, also play active roles in the onset and progression of CRC. Recently, small dense low-density lipoprotein (LDL) particles, a typical characteristic of diabetic dyslipidemia, emerged as another possible underlying link between T2DM and CRC. Growing evidence suggests that antidiabetic medications may have beneficial effects in CRC prevention. According to findings from a limited number of preclinical and clinical studies, glucagon-like peptide-1 receptor agonists (GLP-1RAs) could be a promising strategy in reducing the incidence of CRC in patients with diabetes. However, available findings are inconclusive, and further studies are required. In this review, novel evidence on molecular mechanisms linking T2DM with CRC development, progression, and survival will be discussed. In addition, the potential role of GLP-1RAs therapies in CRC prevention will also be evaluated.
C1 [Vekic, Jelena; Zeljkovic, Aleksandra; Stefanovic, Aleksandra] Univ Belgrade, Fac Pharm, Dept Med Biochem, Belgrade 11000, Serbia.
   [Giglio, Rosaria Vincenza; Ciaccio, Marcello] Univ Palermo, Dept Biomed Neurosci & Adv Diagnost, I-90100 Palermo, Italy.
   [Ciaccio, Marcello] Univ Hosp, Dept Lab Med, I-90100 Palermo, Italy.
   [Rizzo, Manfredi] Univ Palermo, Dept Hlth Promot Mother & Child Care, Internal Med & Med Specialties, I-90100 Palermo, Italy.
C3 University of Belgrade; University of Palermo; University of Palermo
RP Rizzo, M (corresponding author), Univ Palermo, Dept Hlth Promot Mother & Child Care, Internal Med & Med Specialties, I-90100 Palermo, Italy.
EM jelena.vekic@pharmacy.bg.ac.rs; aleksandra.zeljkovic@pharmacy.bg.ac.rs;
   alex@pharmacy.bg.ac.rs; giglio.rosaria.vincenza@gmail.com;
   marcello.ciaccio@unipa.it; manfredi.rizzo@unipa.it
RI RIZZO, MANFREDI/GZL-0551-2022; GIGLIO, Rosaria Vincenza/IAR-9444-2023
OI Stefanovic, Aleksandra/0000-0002-0331-6807; Zeljkovic,
   Aleksandra/0000-0001-6417-8404; Ciaccio, Marcello/0000-0001-6120-9041;
   GIGLIO, Rosaria Vincenza/0000-0002-7968-1480; RIZZO,
   Manfredi/0000-0002-9549-8504; Vekic, Jelena/0000-0001-7445-0504
FU Ministry of Education, Science and Technological Development, Republic
   of Serbia [451-03-9/2021-14/200161]
FX The authors from Faculty of Pharmacy, University of Belgrade appreciate
   sup-port from Ministry of Education, Science and Technological
   Development, Republic of Serbia (grantno. 451-03-9/2021-14/200161).
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NR 201
TC 21
Z9 24
U1 0
U2 15
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD NOV
PY 2021
VL 22
IS 22
AR 12409
DI 10.3390/ijms222212409
PG 21
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA XG1ZQ
UT WOS:000724558600001
PM 34830295
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Galicia-Moreno, M
   Lucano-Landeros, S
   Monroy-Ramirez, HC
   Silva-Gomez, J
   Gutierrez-Cuevas, J
   Santos, A
   Armendariz-Borunda, J
AF Galicia-Moreno, Marina
   Lucano-Landeros, Silvia
   Monroy-Ramirez, Hugo Christian
   Silva-Gomez, Jorge
   Gutierrez-Cuevas, Jorge
   Santos, Arturo
   Armendariz-Borunda, Juan
TI Roles of Nrf2 in Liver Diseases: Molecular, Pharmacological, and
   Epigenetic Aspects
SO ANTIOXIDANTS
LA English
DT Review
DE antioxidants; liver damage; Nrf2; epigenetics
ID HIGH-FAT DIET; UNFOLDED PROTEIN RESPONSE; TRANSCRIPTION FACTOR NRF2;
   HEPATIC OXIDATIVE STRESS; NF-KAPPA-B; NONALCOHOLIC STEATOHEPATITIS;
   HEPATOCELLULAR-CARCINOMA; CARBON-TETRACHLORIDE; INSULIN-RESISTANCE;
   METABOLIC SYNDROME
AB Liver diseases represent a critical health problem with 2 million deaths worldwide per year, mainly due to cirrhosis and its complications. Oxidative stress plays an important role in the development of liver diseases. In order to maintain an adequate homeostasis, there must be a balance between free radicals and antioxidant mediators. Nuclear factor erythroid 2-related factor (Nrf2) and its negative regulator Kelch-like ECH-associated protein 1 (Keap1) comprise a defense mechanism against oxidative stress damage, and growing evidence considers this signaling pathway as a key pharmacological target for the treatment of liver diseases. In this review, we provide detailed and updated evidence regarding Nrf2 and its involvement in the development of the main liver diseases such as alcoholic liver damage, viral hepatitis, steatosis, steatohepatitis, cholestatic damage, and liver cancer. The molecular and cellular mechanisms of Nrf2 cellular signaling are elaborated, along with key and relevant antioxidant drugs, and mechanisms on how Keap1/Nrf2 modulation can positively affect the therapeutic response are described. Finally, exciting recent findings about epigenetic modifications and their link with regulation of Keap1/Nrf2 signaling are outlined.
C1 [Galicia-Moreno, Marina; Lucano-Landeros, Silvia; Monroy-Ramirez, Hugo Christian; Silva-Gomez, Jorge; Gutierrez-Cuevas, Jorge; Armendariz-Borunda, Juan] Univ Guadalajara, Ctr Univ Ciencias Salud, Inst Biol Mol Med, Guadalajara 44340, Jalisco, Mexico.
   [Santos, Arturo; Armendariz-Borunda, Juan] Tecnol Monterrey, Escuela Med & Ciencias Salud, Zapopan 45201, Jalisco, Mexico.
C3 Universidad de Guadalajara; Tecnologico de Monterrey
RP Armendariz-Borunda, J (corresponding author), Univ Guadalajara, Ctr Univ Ciencias Salud, Inst Biol Mol Med, Guadalajara 44340, Jalisco, Mexico.; Armendariz-Borunda, J (corresponding author), Tecnol Monterrey, Escuela Med & Ciencias Salud, Zapopan 45201, Jalisco, Mexico.
EM marina.galicia@academicos.udg.mx; silvia.lucano@gmail.com;
   hugo.monroyram@academicos.udg.mx; xntonio.silva@gmail.com;
   gutierrezcj05@gmail.com; arturo.santos@tec.mx; armdbo@gmail.com
RI Galicia-Moreno, Marina/AAQ-5089-2021; Santos, Arturo/GQQ-1431-2022;
   Armendáriz-Borunda, Juan/AAU-1471-2021; Silva-Gomez, Jorge
   Antonio/Z-1881-2018
OI Galicia-Moreno, Marina/0000-0002-7435-1861; Gutierrez-Cuevas,
   Jorge/0000-0003-0276-0428; Silva-Gomez, Jorge
   Antonio/0000-0003-4946-8088; Monroy-Ramirez, Hugo
   Christian/0000-0001-8891-5317; Armendariz-Borunda,
   Juan/0000-0002-7101-9943
FU Fondo de Desarrollo Cientifico de Jalisco [7941-2019, FODECIJAL
   8149-2019]; JorgeASilva-Gomez is member of the CONACYT Doctoral
   Fellowship Program
FX This work was supported in part by Fondo de Desarrollo Cientifico de
   Jalisco, FODECIJAL, 7941-2019 awarded to Juan Armendariz-Borunda and
   FODECIJAL 8149-2019 to Jorge Gutierrez-Cuevas. JorgeASilva-Gomez is
   member of the CONACYT Doctoral Fellowship Program.
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NR 132
TC 83
Z9 91
U1 3
U2 35
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD OCT
PY 2020
VL 9
IS 10
AR 980
DI 10.3390/antiox9100980
PG 23
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA OJ6SJ
UT WOS:000584088200001
PM 33066023
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Broome, SC
   Woodhead, JST
   Merry, TL
AF Broome, Sophie C.
   Woodhead, Jonathan S. T.
   Merry, Troy L.
TI Mitochondria-Targeted Antioxidants and Skeletal Muscle Function
SO ANTIOXIDANTS
LA English
DT Review
DE mitochondria; reactive oxygen species; oxidative stress; skeletal
   muscle; antioxidant
ID TRAINING-INDUCED ADAPTATIONS; INDUCED INSULIN-RESISTANCE; OXIDATIVE
   STRESS; REACTIVE OXYGEN; N-ACETYLCYSTEINE; VITAMIN-C;
   SUPEROXIDE-PRODUCTION; CONTRACTILE PROPERTIES; REPERFUSION INJURY;
   METABOLIC SYNDROME
AB One of the main sources of reactive oxygen species (ROS) in skeletal muscle is the mitochondria. Prolonged or very high ROS exposure causes oxidative damage, which can be deleterious to muscle function, and as such, there is growing interest in targeting antioxidants to the mitochondria in an effort to prevent or treat muscle dysfunction and damage associated with disease and injury. Paradoxically, however, ROS also act as important signalling molecules in controlling cellular homeostasis, and therefore caution must be taken when supplementing with antioxidants. It is possible that mitochondria-targeted antioxidants may limit oxidative stress without suppressing ROS from non-mitochondrial sources that might be important for cell signalling. Therefore, in this review, we summarise literature relating to the effect of mitochondria-targeted antioxidants on skeletal muscle function. Overall, mitochondria-targeted antioxidants appear to exert beneficial effects on mitochondrial capacity and function, insulin sensitivity and age-related declines in muscle function. However, it seems that this is dependent on the type of mitochondrial-trageted antioxidant employed, and its specific mechanism of action, rather than simply targeting to the mitochondria.
C1 [Broome, Sophie C.; Woodhead, Jonathan S. T.; Merry, Troy L.] Univ Auckland, Fac Med & Hlth Sci, Discipline Nutr, Auckland 1023, New Zealand.
   [Merry, Troy L.] Univ Auckland, Maurice Wilkins Ctr Mol Biodiscovery, Auckland 1023, New Zealand.
C3 University of Auckland; University of Auckland
RP Merry, TL (corresponding author), Univ Auckland, Fac Med & Hlth Sci, Discipline Nutr, Auckland 1023, New Zealand.; Merry, TL (corresponding author), Univ Auckland, Maurice Wilkins Ctr Mol Biodiscovery, Auckland 1023, New Zealand.
EM s.broome@auckland.ac.nz; j.woodhead@auckland.ac.nz;
   t.merry@auckland.ac.nz
RI Broome, Sophie/ITR-8962-2023
OI Broome, Sophie/0000-0002-4163-7847
FU Marsden Fund Fast Start Grant [16-UOA-313]; Rutherford Discovery
   Fellowship [15-UOA-020]; Callaghan Innovation R and D Fellowship
FX The writing of this review was supported by the Marsden Fund Fast Start
   Grant (16-UOA-313 to T.L.M.), and T.L.M. is supported by a Rutherford
   Discovery Fellowship (15-UOA-020). S.C.B. is supported by a Callaghan
   Innovation R and D Fellowship.
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Z9 35
U1 1
U2 21
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD AUG
PY 2018
VL 7
IS 8
AR 107
DI 10.3390/antiox7080107
PG 12
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA GS1AT
UT WOS:000443246700012
PM 30096848
OA Green Submitted, gold, Green Published
DA 2025-06-11
ER

PT J
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TI Metabolic injury-induced NLRP3 inflammasome activation dampens
   phospholipid degradation
SO SCIENTIFIC REPORTS
LA English
DT Article
ID FATTY-ACID OXIDATION; ADIPOSE-TISSUE; E-LDL; SIRT1; STRESS; AMPK; RISK;
   ATHEROSCLEROSIS; MODULATION; AUTOPHAGY
AB The collateral effects of obesity/metabolic syndrome include inflammation and renal function decline. As renal disease in obesity can occur independently of hypertension and diabetes, other yet undefined causal pathological pathways must be present. Our study elucidate novel pathological pathways of metabolic renal injury through LDL-induced lipotoxicity and metainflammation. Our in vitro and in vivo analysis revealed a direct lipotoxic effect of metabolic overloading on tubular renal cells through a multifaceted mechanism that includes intralysosomal lipid amassing, lysosomal dysfunction, oxidative stress, and tubular dysfunction. The combination of these endogenous metabolic injuries culminated in the activation of the innate immune NLRP3 inflammasome complex. By inhibiting the sirtuin-1/LKB1/AMPK pathway, NLRP3 inflammasome dampened lipid breakdown, thereby worsening the LDL-induced intratubular phospholipid accumulation. Consequently, the presence of NLRP3 exacerbated tubular oxidative stress, mitochondrial damage and malabsorption during overnutrition. Altogether, our data demonstrate a causal link between LDL and tubular damage and the creation of a vicious cycle of excessive nutrients-NLRP3 activation-catabolism inhibition during metabolic kidney injury. Hence, this study strongly highlights the importance of renal epithelium in lipid handling and recognizes the role of NLRP3 as a central hub in metainflammation and immunometabolism in parenchymal non-immune cells.
C1 [Rampanelli, Elena; Ochodnicky, Peter; Bakker, Pieter J.; Claessen, Nike; Butter, Loes M.; Weerman, Marius A. van den Bergh; Florquin, Sandrine; Leemans, Jaklien C.] Univ Amsterdam, Acad Med Ctr Amsterdam, Dept Pathol, NL-1105 AZ Amsterdam, Netherlands.
   [Rampanelli, Elena; Orso, Evelyn; Liebisch, Gerhard; Schmitz, Gerd] Univ Hosp Regensburg, Inst Clin Chem & Lab Med, D-93053 Regensburg, Germany.
C3 University of Amsterdam; Academic Medical Center Amsterdam; University
   of Regensburg
RP Rampanelli, E (corresponding author), Univ Amsterdam, Acad Med Ctr Amsterdam, Dept Pathol, NL-1105 AZ Amsterdam, Netherlands.; Rampanelli, E (corresponding author), Univ Hosp Regensburg, Inst Clin Chem & Lab Med, D-93053 Regensburg, Germany.
EM e.rampanelli@amc.uva.nl
RI Leemans, Jaklien/AAM-4958-2020; Rampanelli, Elena/AAJ-9119-2020;
   Liebisch, Gerhard/G-6130-2010
OI Liebisch, Gerhard/0000-0003-4886-0811; Florquin,
   Sandrine/0000-0002-9676-1722; Rampanelli, Elena/0000-0002-7742-0092;
   Leemans, Jaklien/0000-0002-0104-6751
FU Netherlands Organisation for Scientific Research (NWO Vidi) [91712386];
   Netherlands Organisation for Scientific Research (NWO Aspasia)
   [015008004]; EU [202272]
FX We thank Doreen Muller and Simone Peschel for excellent technical
   assistance. This study was supported by the Netherlands Organisation for
   Scientific Research (NWO Vidi #91712386, NWO Aspasia #015008004) and by
   EU-funded "LipidomicNet" project (#202272).
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NR 50
TC 35
Z9 38
U1 0
U2 5
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD JUN 6
PY 2017
VL 7
AR 2861
DI 10.1038/s41598-017-01994-9
PG 13
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA FX2RS
UT WOS:000425909800001
PM 28588189
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Gong, Y
   Luo, HJ
   Li, ZJ
   Feng, YJ
   Liu, Z
   Chang, J
AF Gong, Yuan
   Luo, Hongjie
   Li, Zeju
   Feng, Yijun
   Liu, Zhen
   Chang, Jie
TI Metabolic Profile of Alzheimer's Disease: Is 10-Hydroxy-2-decenoic Acid
   a Pertinent Metabolic Adjuster?
SO METABOLITES
LA English
DT Review
DE Alzheimer's disease; diabetes mellitus; obesity; 10-HDA; molecular
   docking
ID TYPE-2 DIABETES-MELLITUS; BRAIN-BARRIER DISRUPTION; OXIDATIVE STRESS;
   RECEPTOR AGONISTS; INSULIN; OBESITY; DYSFUNCTION; BIOMARKERS; LEPTIN;
   ALPHA
AB Alzheimer's disease (AD) represents a significant public health concern in modern society. Metabolic syndrome (MetS), which includes diabetes mellitus (DM) and obesity, represents a modifiable risk factor for AD. MetS and AD are interconnected through various mechanisms, such as mitochondrial dysfunction, oxidative stress, insulin resistance (IR), vascular impairment, inflammation, and endoplasmic reticulum (ER) stress. Therefore, it is necessary to seek a multi-targeted and safer approach to intervention. Thus, 10-hydroxy-2-decenoic acid (10-HDA), a unique hydroxy fatty acid in royal jelly, has shown promising anti-neuroinflammatory, blood-brain barrier (BBB)-preserving, and neurogenesis-promoting properties. In this paper, we provide a summary of the relationship between MetS and AD, together with an introduction to 10-HDA as a potential intervention nutrient. In addition, molecular docking is performed to explore the metabolic tuning properties of 10-HDA with associated macromolecules such as GLP-1R, PPARs, GSK-3, and TREM2. In conclusion, there is a close relationship between AD and MetS, and 10-HDA shows potential as a beneficial nutritional intervention for both AD and MetS.
C1 [Gong, Yuan; Luo, Hongjie; Li, Zeju; Feng, Yijun; Liu, Zhen; Chang, Jie] Soochow Univ, Sch Publ Hlth, Dept Occupat & Environm Hlth, 199 Renai Rd, Suzhou 215123, Peoples R China.
C3 Soochow University - China
RP Chang, J (corresponding author), Soochow Univ, Sch Publ Hlth, Dept Occupat & Environm Hlth, 199 Renai Rd, Suzhou 215123, Peoples R China.
EM bravogary@yandex.com; jchang@suda.edu.cn
RI Chang, Jie/AFR-8580-2022
OI Gong, Yuan/0009-0008-6745-9867
FU We appreciate the administrative and technical support from Jie Chang.
FX We appreciate the administrative and technical support from Jie Chang.
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NR 172
TC 2
Z9 3
U1 4
U2 28
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2218-1989
J9 METABOLITES
JI Metabolites
PD AUG
PY 2023
VL 13
IS 8
AR 954
DI 10.3390/metabo13080954
PG 23
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA Q1QF7
UT WOS:001055327900001
PM 37623897
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Matafome, P
AF Matafome, Paulo
TI Another Player in the Field: Involvement of Glycotoxins and Glycosative
   Stress in Insulin Secretion and Resistance
SO DIABETOLOGY
LA English
DT Review
DE glycation; glycotoxins; glycosative stress; insulin resistance;
   glyoxalase
ID GLYCATION END-PRODUCTS; PANCREATIC BETA-CELL; METHYLGLYOXAL
   ACCUMULATION; MITOCHONDRIAL DYSFUNCTION; METABOLIC SYNDROME; GLYOXALASE
   SYSTEM; OXIDATIVE STRESS; UP-REGULATION; ENDPRODUCTS; IMPAIRS
AB The term glycotoxins includes the group of advanced glycation end-products (AGEs) and their precursors, most of them highly reactive intermediary compounds, such as methylglyoxal (MG). Glycotoxins were initially thought to participate in the development of diabetic complications because of their increased formation from glucose. However, they also form and accumulate in tissues since the early stages of disease, such as metabolically unhealthy obesity and prediabetes. Such accumulation has been suggested to result from dysregulated activity of detoxification systems, such as the glyoxalase system, as well as increased dietary consumption, namely from high-glucose and high-fructose foods processed at high temperatures. Although some studies may have used supraphysiological doses, in vitro systems and animal models have shown glycotoxin-induced insulin resistance. Moreover, dietary glycotoxin restriction was shown to improve insulin resistance in humans and glyoxalase (GLO)-1 upregulation improved insulin sensitivity and metabolic function. This review summarizes the current knowledge about glycotoxin involvement in the development of insulin resistance, the mechanisms involved and the usefulness of GLO-1 modulation, and a possible therapeutic strategy to improve insulin sensitivity.
C1 [Matafome, Paulo] Univ Coimbra, Coimbra Inst Clin & Biomed Res iCBR, Fac Med, P-3000548 Coimbra, Portugal.
   [Matafome, Paulo] Univ Coimbra, Inst Physiol, Fac Med, P-3000548 Coimbra, Portugal.
   [Matafome, Paulo] Univ Coimbra, Ctr Innovat Biomed & Biotechnol CIBB, P-3000548 Coimbra, Portugal.
   [Matafome, Paulo] Clin Acad Ctr Coimbra CACC, P-3004561 Coimbra, Portugal.
   [Matafome, Paulo] Inst Politecn Coimbra, Coimbra Hlth Sch ESTeSC, Dept Complementary Sci, P-3045601 Coimbra, Portugal.
   [Matafome, Paulo] Pole III Univ Coimbra, Fac Med, Subunit 1,1st Floor, P-3000548 Coimbra, Coimbra, Portugal.
C3 Universidade de Coimbra; Universidade de Coimbra; Universidade de
   Coimbra; Universidade de Coimbra; Instituto Politecnico de Coimbra
   (IPC); Universidade de Coimbra
RP Matafome, P (corresponding author), Univ Coimbra, Coimbra Inst Clin & Biomed Res iCBR, Fac Med, P-3000548 Coimbra, Portugal.; Matafome, P (corresponding author), Univ Coimbra, Inst Physiol, Fac Med, P-3000548 Coimbra, Portugal.; Matafome, P (corresponding author), Univ Coimbra, Ctr Innovat Biomed & Biotechnol CIBB, P-3000548 Coimbra, Portugal.; Matafome, P (corresponding author), Clin Acad Ctr Coimbra CACC, P-3004561 Coimbra, Portugal.; Matafome, P (corresponding author), Inst Politecn Coimbra, Coimbra Hlth Sch ESTeSC, Dept Complementary Sci, P-3045601 Coimbra, Portugal.; Matafome, P (corresponding author), Pole III Univ Coimbra, Fac Med, Subunit 1,1st Floor, P-3000548 Coimbra, Coimbra, Portugal.
EM paulo.matafome@uc.pt
RI Matafome, Paulo/AAQ-4113-2020
OI Matafome, Paulo/0000-0002-3422-290X
FU Portuguese Foundation of Science and Technology [UID/NEU/04539/2013,
   UID/NEU/04539/2019]
FX This research was funded by Portuguese Foundation of Science and
   Technology (Strategic Projects UID/NEU/04539/2013 and
   UID/NEU/04539/2019).
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NR 92
TC 3
Z9 3
U1 1
U2 1
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2673-4540
J9 DIABETOLOGY
JI Diabetol.
PD DEC
PY 2020
VL 1
IS 1
BP 24
EP 36
DI 10.3390/diabetology1010004
PG 13
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA AA2S6
UT WOS:001115671600001
OA gold
DA 2025-06-11
ER

PT J
AU Aparicio, A
   Cuevas, J
   Morís, C
   Martín, M
AF Aparicio, Andrea
   Cuevas, Javier
   Moris, Cesar
   Martin, Maria
TI Slow Coronary Blood Flow: Pathogenesis and Clinical Implications
SO EUROPEAN CARDIOLOGY REVIEW
LA English
DT Review
DE Coronary slow flow; angina; angiography; acute coronary syndrome
ID LEFT-VENTRICULAR FUNCTION; ENDOTHELIAL FUNCTION; OXIDATIVE STRESS;
   PLASMA HOMOCYSTEINE; ANGINA-PECTORIS; RISK-FACTORS; ARTERIES; LEVEL;
   NITROGLYCERIN; PREVALENCE
AB Coronary slow flow (CSF) phenomenon, also known as cardiac syndrome Y, is defined as the delayed opacification of the coronary vasculature at the distal level. Different hypotheses and theories have been postulated about its substrate and mechanism, such as microvascular and endothelial dysfunction. Several studies have confirmed that CSF is a cause of ischaemia detected by non-invasive testing. Clinically, it can present as angina pectoris, acute coronary syndrome and sudden cardiac death. It has an incidence of 1-5% in patients undergoing coronary angiography and has been most frequently found in young men who are smokers with metabolic syndrome. There are no established treatments for CSF and further studies are still necessary.
C1 [Aparicio, Andrea; Cuevas, Javier; Moris, Cesar; Martin, Maria] Hosp Univ Cent Asturias, Area Gest Clin Corazon, Avda Roma S-N, Oviedo 33001, Asturias, Spain.
C3 Central University Hospital Asturias
RP Martín, M (corresponding author), Hosp Univ Cent Asturias, Area Gest Clin Corazon, Avda Roma S-N, Oviedo 33001, Asturias, Spain.
EM mmartinf7@hotmail.com
RI Moris, Cesar/AAG-2018-2020
OI Moris, Cesar/0000-0002-2871-190X
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NR 63
TC 27
Z9 29
U1 3
U2 20
PU RADCLIFFE CARDIOLOGY
PI BUCKS
PA UNIT F, BOURNE END BUSINESS PARK, BOURNE END, BUCKS, SL8 5AS, ENGLAND
SN 1758-3756
J9 EUR CARDIOL REV
JI Eur. Cardiol. Rev.
PY 2022
VL 17
AR e08
DI 10.15420/ecr.2021.46
PG 6
WC Cardiac & Cardiovascular Systems
WE Emerging Sources Citation Index (ESCI)
SC Cardiovascular System & Cardiology
GA ZS7OX
UT WOS:000768652500001
PM 35356630
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Moltedo, O
   Remondelli, P
   Amodio, G
AF Moltedo, Ornella
   Remondelli, Paolo
   Amodio, Giuseppina
TI The Mitochondria-Endoplasmic Reticulum Contacts and Their Critical Role
   in Aging and Age-Associated Diseases
SO FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
LA English
DT Review
DE aging; age-associated diseases; oxidative stress; senescence;
   endoplasmic reticulum; mitochondria
ID UNFOLDED PROTEIN RESPONSE; OXIDATIVE STRESS; MITOFUSIN 2; LIFE-SPAN;
   PHOSPHOLIPID TRANSFER; ALZHEIMERS-DISEASE; VAPB INTERACTS; ER MEMBRANES;
   CELL; AUTOPHAGY
AB The recent discovery of interconnections between the endoplasmic reticulum (ER) membrane and those of almost all the cell compartments is providing novel perspectives for the understanding of the molecular events underlying cellular mechanisms in both physiological and pathological conditions. In particular, growing evidence strongly supports the idea that the molecular interactions occurring between ER and mitochondrial membranes, referred as the mitochondria (MT)-ER contacts (MERCs), may play a crucial role in aging and in the development of age-associated diseases. As emerged in the last decade, MERCs behave as signaling hubs composed by structural components that act as critical players in different age-associated disorders, such as neurodegenerative diseases and motor disorders, cancer, metabolic syndrome, as well as cardiovascular diseases. Age-associated disorders often derive from mitochondrial or ER dysfunction as consequences of oxidative stress, mitochondrial DNA mutations, accumulation of misfolded proteins, and defective organelle turnover. In this review, we discuss the recent advances associating MERCs to aging in the context of ER-MT crosstalk regulating redox signaling, ER-to MT lipid transfer, mitochondrial dynamics, and autophagy.
C1 [Moltedo, Ornella] Univ Salerno, Dept Pharm, Fisciano, Italy.
   [Remondelli, Paolo; Amodio, Giuseppina] Scuola Med Saiemitana Univ Salerno, Dept Med Surg & Dent, Baronissi, Italy.
C3 University of Salerno
RP Remondelli, P; Amodio, G (corresponding author), Scuola Med Saiemitana Univ Salerno, Dept Med Surg & Dent, Baronissi, Italy.
EM premondelli@unisa.it; gamodio@unisa.it
RI ; Amodio, Giuseppina/J-8755-2018
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NR 153
TC 113
Z9 118
U1 2
U2 18
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-634X
J9 FRONT CELL DEV BIOL
JI Front. Cell. Dev. Biol.
PD AUG 21
PY 2019
VL 7
AR 172
DI 10.3389/fcell.2019.00172
PG 13
WC Cell Biology; Developmental Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Developmental Biology
GA IS0QK
UT WOS:000481856300001
PM 31497601
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Grose, JH
   Rutter, J
AF Grose, Julianne H.
   Rutter, Jared
TI The Role of PAS Kinase in PASsing the Glucose Signal
SO SENSORS
LA English
DT Review
DE PAS kinase; PASKIN; glucose sensor; protein phosphorylation; PAS domain;
   metabolic syndrome
ID PHOTOACTIVE YELLOW PROTEIN; YEAST SACCHAROMYCES-CEREVISIAE; PANCREATIC
   BETA-CELLS; OXYGEN-SENSING DOMAIN; TRANSLATION INITIATION;
   SERINE/THREONINE KINASE; GLYCOGEN-SYNTHASE; RIBOSOMAL-SUBUNIT;
   CELLULAR-ENERGY; BINDING
AB PAS kinase is an evolutionarily conserved nutrient responsive protein kinase that regulates glucose homeostasis. Mammalian PAS kinase is activated by glucose in pancreatic beta cells, and knockout mice are protected from obesity, liver triglyceride accumulation, and insulin resistance when fed a high-fat diet. Yeast PAS kinase is regulated by both carbon source and cell integrity stress and stimulates the partitioning of glucose toward structural carbohydrate biosynthesis. In our current model for PAS kinase regulation, a small molecule metabolite binds the sensory PAS domain and activates the enzyme. Although bona fide PAS kinase substrates are scarce, in vitro substrate searches provide putative targets for exploration.
C1 [Grose, Julianne H.] Brigham Young Univ, Dept Mol Biol & Microbiol, Provo, UT 84602 USA.
   [Rutter, Jared] Univ Utah, Dept Biochem, Sch Med, Salt Lake City, UT 84112 USA.
C3 Brigham Young University; Utah System of Higher Education; University of
   Utah
RP Grose, JH (corresponding author), Brigham Young Univ, Dept Mol Biol & Microbiol, Provo, UT 84602 USA.
EM julianne_grose@byu.edu; rutter@biochem.utah.edu
OI Grose, Julianne/0000-0001-8816-6635
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NR 69
TC 17
Z9 24
U1 0
U2 12
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1424-8220
J9 SENSORS-BASEL
JI Sensors
PD JUN
PY 2010
VL 10
IS 6
BP 5668
EP 5682
DI 10.3390/s100605668
PG 15
WC Chemistry, Analytical; Engineering, Electrical & Electronic; Instruments
   & Instrumentation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Engineering; Instruments & Instrumentation
GA 616IJ
UT WOS:000279202100020
PM 22219681
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU de la Fuente-Fernández, M
   de la Fuente-Muñoz, M
   Román-Carmena, M
   Amor, S
   García-Redondo, AB
   Blanco-Rivero, J
   González-Hedström, D
   Espinel, AE
   García-Villalón, AL
   Granado, M
AF de la Fuente-Fernandez, Maria
   de la Fuente-Munoz, Mario
   Roman-Carmena, Marta
   Amor, Sara
   Belen Garcia-Redondo, Ana
   Blanco-Rivero, Javier
   Gonzalez-Hedstrom, Daniel
   Espinel, Alberto E.
   Luis Garcia-Villalon, Angel
   Granado, Miriam
TI Carob Extract Supplementation Together with Caloric Restriction and
   Aerobic Training Accelerates the Recovery of Cardiometabolic Health in
   Mice with Metabolic Syndrome
SO ANTIOXIDANTS
LA English
DT Article
DE obesity; metabolic syndrome; hypertension; insulin resistance; carob
   extract; aerobic training; inflammation; antioxidant
ID PULP PREPARATION RICH; DIET-INDUCED OBESITY; INSULIN-RESISTANCE;
   OXIDATIVE STRESS; CARDIOVASCULAR-DISEASE; ANTIOXIDANT CAPACITY;
   FLAVONOID QUERCETIN; FIBER; POLYPHENOLS; INFLAMMATION
AB Carob, the fruit of Ceratonia siliqua L. exerts antidiabetic, anti-inflammatory, and antioxidant effects and could be a useful strategy for the treatment and/or prevention of metabolic syndrome (MetS). The aim of this study was to analyze whether supplementation with a carob fruit extract (CSAT+(R)), alone or in combination with aerobic training, accelerates the recovery of cardiometabolic health in mice with MetS subjected to a caloric restriction. For this purpose, mice were fed with a high fat (58% kcal from fat)/high sugar diet for 23 weeks to induce MetS. During the next two weeks, mice with MetS were switched to a diet with a lower caloric content (25% kcal from fat) supplemented or not with CSAT+(R) (4.8%) and/or subjected to aerobic training. Both caloric reduction and aerobic training improved the lipid profile and attenuated MetS-induced insulin resistance measured as HOMA-IR. However, only supplementation with CSAT+(R) enhanced body weight loss, increased the circulating levels of adiponectin, and lowered the plasma levels of IL-6. Moreover, CSAT+(R) supplementation was the only effective strategy to reduce the weight of epidydimal adipose tissue and to improve insulin sensitivity in the liver and in skeletal muscle. Although all interventions improved endothelial function in aorta segments, only supplementation with CSAT+(R) reduced obesity-induced hypertension, prevented endothelial dysfunction in mesenteric arteries, and decreased the vascular response of aorta segments to the vasoconstrictor AngIl. The beneficial cardiometabolic effects of CSAT+(R) supplementation, alone or in combination with aerobic training, were associated with decreased mRNA levels of pro-inflammatory markers such as MCP-1, TNF alpha, IL-1 beta, and IL-6 and with increased gene expression of antioxidant enzymes, such as GSR, GPX-3, and SOD-1 in the liver, gastrocnemius, retroperitoneal adipose tissue, and aorta. In conclusion, supplementation with CSAT+(R), alone or in combination with aerobic training, to mice with MetS subjected to caloric restriction for two weeks enhances body weight loss, improves the lipid profile and insulin sensitivity, and exerts antihypertensive effects through its anti-inflammatory and antioxidant properties.
C1 [de la Fuente-Fernandez, Maria; de la Fuente-Munoz, Mario; Roman-Carmena, Marta; Amor, Sara; Belen Garcia-Redondo, Ana; Blanco-Rivero, Javier; Luis Garcia-Villalon, Angel; Granado, Miriam] Univ Autonoma Madrid, Fac Med, Dept Fisiol, Madrid 28029, Spain.
   [Belen Garcia-Redondo, Ana; Blanco-Rivero, Javier] Inst Invest Sanitaria La Paz IdiPaz, Madrid 28029, Spain.
   [Belen Garcia-Redondo, Ana; Blanco-Rivero, Javier] Inst Salud Carlos III, CIBER Enfermedades Cardiovasc, Madrid 28029, Spain.
   [Gonzalez-Hedstrom, Daniel; Espinel, Alberto E.] Pharmact Biotech Prod SLU, R&D Dept, Parque Cient Madrid,Calle Faraday 7, Madrid 28049, Spain.
   [Granado, Miriam] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr, Madrid 28029, Spain.
C3 Autonomous University of Madrid; Instituto de Salud Carlos III; CIBER -
   Centro de Investigacion Biomedica en Red; CIBERCV; Instituto de Salud
   Carlos III; CIBER - Centro de Investigacion Biomedica en Red; CIBEROBN
RP Granado, M (corresponding author), Univ Autonoma Madrid, Fac Med, Dept Fisiol, Madrid 28029, Spain.; Granado, M (corresponding author), Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr, Madrid 28029, Spain.
EM miriam.granado@uam.es
RI Rivero, Javier/ABE-8749-2020; Redondo, Ana/L-8282-2014; Granado,
   Miriam/B-8978-2017; Blanco Rivero, Javier/J-6118-2014
OI Granado, Miriam/0000-0001-9178-8822; Roman Carmena,
   Marta/0000-0001-9104-2959; Blanco Rivero, Javier/0000-0001-7232-2314;
   Gonzalez-Hedstrom, Daniel/0000-0001-9425-1115
FU Mario de la Fuente Munoz [PEJ-2018-AI/SAL-11315, PEJ-2020-AI/BMD-19155]
FX This work has been funded by the company Pharmactive Biotech Products
   S.L.U. Community of Madrid funded the contract of Maria de la
   Fuente-Fernandez (PEJ-2018-AI/SAL-11315) and Mario de la Fuente Munoz
   (PEJ-2020-AI/BMD-19155) through the Youth Employment Program.
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NR 68
TC 2
Z9 2
U1 0
U2 1
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD SEP
PY 2022
VL 11
IS 9
AR 1803
DI 10.3390/antiox11091803
PG 23
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA 4Q6DE
UT WOS:000856170600001
PM 36139877
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU González, IP
   Madariaga, EL
   Avíles, CR
   Lozano, MA
   Escudero, VM
   Sanzana, ND
   Noguera, GI
   Rojas, MV
   Moore-Carrasco, R
AF Palomo Gonzalez, Ivan
   Leiva Madariaga, Elba
   Reyes Aviles, Carlos, Sr.
   Alarcon Lozano, Marcelo
   Mujica Escudero, Veronica
   Diaz Sanzana, Nora
   Icaza Noguera, Gloria
   Vasquez Rojas, Marcela
   Moore-Carrasco, Rodrigo
TI Eighteen-Week Exercise and Nutritional Education Program Did Not Modify
   the Serum Levels of sVCAM-1 and sCD40-L in Subjects with Metabolic
   Syndrome
SO LABMEDICINE
LA English
DT Article
DE metabolic syndrome; cell adhesion molecules; sVCAM-1; sCD40-L
ID CELL-ADHESION MOLECULES; OXIDATIVE STRESS; DIET; INTERVENTION; MARKERS;
   OBESITY; INSULIN; IMMUNE; TALCA; FAT
AB Some cell adhesion molecules increase their serum concentration in the Metabolic Syndrome (MS); among them the sVCAM-1 and sCD40-L surpass their physiopathological importance. Such molecules are associated with endothelium and platelet activation, respectively, and an increase at their serum level can partially provide information on the endothelium damage and platelet activation in individuals with MS. The purpose of this study was to evaluate the effect of an intervention with physical activity and nutrition education on the serum levels of sVCAM-1 and sCD40L.
   The study included 50 non-smoking men and women, between the ages of 39 and 62 years old. All of them had MS as defined by the National Cholesterol Education Program (NCEP). The subjects were randomly separated into the following 2 groups: (a) intervened MS (I-MS, n=27), who participated in the intervention based on exercise for 18 weeks and lectures about nutrition education, and (b) non-intervened MS (NI-MS, n=24), as a control group. All of the participants' basal and final times were determined (18 weeks), the serum concentration of soluble Vascular Cell Adhesion Molecule-1 (sVCAM-1), sCD40L, and some anthropometric and biochemical parameters.
   The non-pharmacologic intervention did not modify the serum levels of sVCAM-1: I-MS group (basal: medium 674 [interquartile range 270] versus final: 641 [240] ng/mL); NI- MS group (basal: 643 [252] and final: 597 [197] ng/mL) (interaction P=0.190). The non-pharmacologic intervention applied to the I-MS group did not modify the serum levels of sCD40-L (basal: 219 [265] versus final: 183.5 [162] pg/mL). However, an increase in the serum levels of sCD40-L in the NI-MS group was observed (basal: 155.5 [142] and final 359.5 [112] pg/mL) (interaction P=0.007).
   When the serum levels of the studied molecules with the MS criteria variables were studied, a significant positive correlation between sCD40-L and waist circumference was observed (P=0.045). The results of the present study show that a physical activity intervention program of only 18 weeks does not reduce the serum levels of sVCAM-1 and sCD40-L.
C1 [Palomo Gonzalez, Ivan; Leiva Madariaga, Elba; Reyes Aviles, Carlos, Sr.; Alarcon Lozano, Marcelo; Vasquez Rojas, Marcela; Moore-Carrasco, Rodrigo] Univ Talca, Fac Ciencias Salud, Dept Bioquim Clin & Inmunohematol, Talca, Chile.
   [Mujica Escudero, Veronica] Univ Talca, Hosp Reg Talca, Programa Diabet, Talca, Chile.
   [Diaz Sanzana, Nora; Icaza Noguera, Gloria] Univ Talca, Inst Matemat & Fis, Talca, Chile.
   [Mujica Escudero, Veronica] Univ Talca, Fac Ciencias Salud, Escuela Med, Talca, Chile.
C3 Universidad de Talca; Universidad de Talca; Universidad de Talca;
   Universidad de Talca
RP González, IP (corresponding author), Univ Talca, Fac Ciencias Salud, Dept Bioquim Clin & Inmunohematol, Talca, Chile.
RI Palomo, Iván/I-4321-2018; Moore-Carrasco, Rodrigo/AAK-3349-2020
OI Palomo, Ivan/0000-0002-9618-8778; alarcon, marcelo/0000-0001-7596-5382;
   Moore-Carrasco, Rodrigo/0000-0003-4870-9660; Icaza,
   Gloria/0000-0002-3192-3428
FU Programa de Investigacion en Factores de Riesgo de Enfermedades
   Cardiovasculares (PIFRECV), Universidad de Talca, Chile
FX Supported by Programa de Investigacion en Factores de Riesgo de
   Enfermedades Cardiovasculares (PIFRECV), Universidad de Talca, Chile.
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NR 32
TC 2
Z9 2
U1 0
U2 2
PU AMER SOC CLINICAL PATHOLOGY
PI CHICAGO
PA 2100 W HARRISON ST, CHICAGO, IL 60612 USA
SN 0007-5027
EI 1943-7730
J9 LABMEDICINE
JI Labmedicine
PD APR
PY 2010
VL 41
IS 4
BP 231
EP 234
DI 10.1309/LMXK8V3R4FEPFVKK
PG 4
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA 575BN
UT WOS:000276039000007
OA Bronze
DA 2025-06-11
ER

PT J
AU Krishna, M
   Krishnaveni, G
   Sargur, V
   Kumaran, K
   Kumar, M
   Nagaraj, K
   Coakley, P
   Karat, SC
   Chandak, GR
   Varghese, M
   Prince, M
   Osmond, C
   Fall, CHD
AF Krishna, Murali
   Krishnaveni, Ghattu, V
   Sargur, Veena
   Kumaran, Kalyanaraman
   Kumar, Mohan
   Nagaraj, Kiran
   Coakley, Patsy
   Karat, Samuel Chirstaprasad
   Chandak, Giriraj R.
   Varghese, Mathew
   Prince, Martin
   Osmond, Clive
   Fall, Caroline H. D.
TI Size at birth, lifecourse factors, and cognitive function in late life:
   findings from the MYsore study of Natal effects on Ageing and Health
   (MYNAH) cohort in South India
SO INTERNATIONAL PSYCHOGERIATRICS
LA English
DT Article
DE birth weight; cognition; cardiometabolic disorders; Developmental
   Origins of Health and Disease (DOHaD); Low- and Middle-Income Countries
   (LMIC)
ID FETAL-GROWTH; PEOPLE BORN; WEIGHT; ABILITY; DISEASE; AGE; PERFORMANCE;
   CHILDHOOD; COUNTRIES; GLUCOSE
AB Objective: To examine if smaller size at birth, an indicator of growth restriction in utero, is associated with lower cognition in late life, and whether this may be mediated by impaired early life brain development and/or adverse cardiometabolic programming. Design: Longitudinal follow-up of a birth cohort. Setting: CSI Holdsworth Memorial Hospital (HMH), Mysore South India. Participants: 721 men and women (55-80 years) whose size at birth was recorded at HMH. Approximately 20 years earlier, a subset (n = 522) of them had assessments for cardiometabolic disorders in mid-life. Measurements: Standardized measurement of cognitive function, depression, sociodemographic, and lifestyle factors; blood tests and assessments for cardiometabolic disorders Results: Participants who were heavier at birth had higher composite cognitive scores (0.12 SD per SD birth weight [95% CI 0.05, 0.19] p = 0.001) in late life. Other lifecourse factors independently positively related to cognition were maternal educational level and participants' own educational level, adult leg length, body mass index, and socioeconomic position, and negatively were diabetes in mid-life and current depression and stroke. The association of birth weight with cognition was independent cardiometabolic risk factors and was attenuated after adjustment for all lifecourse factors (0.08 SD per SD birth weight [95% CI -0.01, 0.18] p = 0.07). Conclusions: The findings are consistent with positive effects of early life environmental factors (better fetal growth, education, and childhood socioeconomic status) on brain development resulting in greater long-term cognitive function. The results do not support a pathway linking poorer fetal development with reduced late life cognitive function through cardiometabolic programming.
C1 [Krishna, Murali; Krishnaveni, Ghattu, V; Sargur, Veena; Kumaran, Kalyanaraman; Kumar, Mohan; Nagaraj, Kiran; Karat, Samuel Chirstaprasad] CSI Holdsworth Mem Hosp, Mysore, Karnataka, India.
   [Krishna, Murali] Fdn Res & Advocacy Mental Hlth Mysore, Mysore, Karnataka, India.
   [Kumaran, Kalyanaraman; Osmond, Clive; Fall, Caroline H. D.] Univ Southampton, MRC Lifecourse Epidemiol Unit, Southampton, Hants, England.
   [Coakley, Patsy] Univ Southampton, Lifecourse Epidemiol Unit, Univ Rd, Southampton SO17 1BJ, Hants, England.
   [Chandak, Giriraj R.] CSIR Ctr Cellular & Mol Biol, Hyderabad, India.
   [Varghese, Mathew] Natl Inst Mental Hlth & Neurosci, Bangalore, Karnataka, India.
   [Prince, Martin] Kings Coll London, Inst Psychiat, London, England.
C3 University of Southampton; University of Southampton; Council of
   Scientific & Industrial Research (CSIR) - India; CSIR - Centre for
   Cellular & Molecular Biology (CCMB); National Institute of Mental Health
   & Neurosciences - India; University of London; King's College London
RP Fall, CHD (corresponding author), Univ Southampton, Lifecourse Epidemiol Unit, Univ Rd, Southampton SO17 1BJ, Hants, England.
EM chdf@mrc.soton.ac.uk
RI M, MOHAN/AAI-7121-2021; Krishna, Murali/HMD-3872-2023; Varghese,
   Mathew/AAG-8341-2019; Kumaran, Kalyanaraman/KCK-5741-2024; Varghese,
   Mathew/M-9900-2016
OI Krishna, Murali/0000-0002-9590-5798; Varghese,
   Mathew/0000-0001-5670-5710; Osmond, Clive/0000-0002-9054-4655
FU Welcome DBT India Alliance
FX This study was supported by an Early Career Fellowship grant awarded to
   Dr Murali Krishna by Welcome DBT India Alliance.
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NR 43
TC 6
Z9 6
U1 2
U2 6
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1041-6102
EI 1741-203X
J9 INT PSYCHOGERIATR
JI Int. Psychogeriatr.
PD APR
PY 2022
VL 34
IS 4
SI SI
BP 353
EP 366
AR PII S1041610221001186
DI 10.1017/S1041610221001186
EA OCT 2021
PG 14
WC Psychology, Clinical; Geriatrics & Gerontology; Gerontology; Psychiatry;
   Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Geriatrics & Gerontology; Psychiatry
GA 1C5DU
UT WOS:000768626600001
PM 34666849
OA Green Accepted, hybrid
DA 2025-06-11
ER

PT J
AU Ding, SZ
   Wu, DD
   Lu, QOT
   Qian, L
   Ding, YB
   Liu, GORG
   Jia, XQ
   Zhang, Y
   Xiao, WM
   Gong, WJ
AF Ding, Shizhen
   Wu, Dandan
   Lu, Quotao
   Qian, Li
   Ding, Yanbing
   Liu, George
   Jia, Xiaoqin
   Zhang, Yu
   Xiao, Weiming
   Gong, Weijuan
TI Angiopoietin-like 4 deficiency upregulates macrophage function through
   the dysregulation of cell-intrinsic fatty acid metabolism
SO AMERICAN JOURNAL OF CANCER RESEARCH
LA English
DT Article
DE ANGPTL4; deficiency; macrophage; fatty acid; metabolism
ID INHIBITION; PROTECTS; VARIANT; RISK; GENE
AB Angiopoietin-like 4 (ANGPLT4) regulates lipid metabolism by inhibiting lipoprotein lipase. Abnormal ANGTPL4 levels are associated with metabolic syndrome, atherosclerosis, inflammation, and cancer. We show here that ANGPTL4-deficient mice have abnormally large numbers of macrophages in the spleen, and that these macrophages produce large amounts of TNF-alpha, CD86, and inducible nitric oxide synthase. However, recombinant ANGPTL4 protein did not inhibit macrophage function ex vivo. Glycolysis and fatty-acid synthesis were upregulated in ANGPTL4(-/-) macrophages, whereas fatty-acid oxidation was decreased. Elevated levels of free fatty acids in the cytoplasm of ANGPTL4(-/-) macrophages were confirmed. ANGPTL4(-/-) macrophages also displayed endoplasmic reticulum (ER) stress after stimulation with LPS. Protein kinase B (Akt)/mammalian target of rapamycin (mTOR) signaling was activated, but no major change in liver kinase B1 (LKB1)/adenosine 5'-monophosphate (AMP)- activated protein kinase (AMPK) phosphorylation was observed in ANGPTL4(-/-) macrophages. The modulation of fatty-acid metabolism prevented ER stress and the expression of inflammatory molecules, but the activation of ANGPTL4(-/-) macrophages was not restored by the inhibition of glycolysis. Thus, ANGPTL4 deficiency in macrophages results in ER stress due to the cell-intrinsic reprogramming of fatty-acid metabolism. Intracellular ANGPLT4 expression could thus be manipulated to modulate macrophage function.
C1 [Ding, Shizhen; Wu, Dandan; Qian, Li; Gong, Weijuan] Yangzhou Univ, Sch Med, Dept Immunol, Yangzhou 225001, Jiangsu, Peoples R China.
   [Lu, Quotao; Ding, Yanbing; Xiao, Weiming; Gong, Weijuan] Yangzhou Univ, Affiliated Hosp, Dept Gastroenterol, Yangzhou 225001, Jiangsu, Peoples R China.
   [Ding, Shizhen; Wu, Dandan; Qian, Li; Jia, Xiaoqin; Zhang, Yu; Xiao, Weiming; Gong, Weijuan] Jiangsu Key Lab Integrated Tradit Chinese & Weste, Yangzhou 225001, Jiangsu, Peoples R China.
   [Liu, George] Peking Univ, Key Lab Mol Cardiovasc Sci, Minist Educ, Inst Cardiovasc Sci, Beijing 100191, Peoples R China.
   [Jia, Xiaoqin; Zhang, Yu; Xiao, Weiming; Gong, Weijuan] Jiangsu Key Lab Zoonosis, Yangzhou 225001, Jiangsu, Peoples R China.
   [Gong, Weijuan] Jiangsu Coinnovat Ctr Prevent & Control Important, Yangzhou 225001, Jiangsu, Peoples R China.
C3 Yangzhou University; Yangzhou University; Ministry of Education - China;
   Peking University; Yangzhou University
RP Gong, WJ (corresponding author), Sch Med, Dept Immunol, Jiangyang Rd 136, Yangzhou, Jiangsu, Peoples R China.
EM wjgong@yzu.edu.cn
OI Wu, Dandan/0000-0002-0453-008X; Gong, Weijuan/0000-0002-8543-1314
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NR 31
TC 13
Z9 13
U1 0
U2 5
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 2156-6976
J9 AM J CANCER RES
JI Am. J. Cancer Res.
PY 2020
VL 10
IS 2
BP 595
EP 609
PG 15
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA KS0YF
UT WOS:000518037100017
PM 32195030
DA 2025-06-11
ER

PT J
AU Anupama, N
   Sindhu, G
   Raghu, KG
AF Anupama, Nair
   Sindhu, Ganapathy
   Raghu, Kozhiparambil Gopalan
TI Significance of mitochondria on cardiometabolic syndromes
SO FUNDAMENTAL & CLINICAL PHARMACOLOGY
LA English
DT Review
DE calcium; cardiolipins; FOXO3a; mitochondria; reactive oxygen species;
   thioredoxin
ID ACTIVATED PROTEIN-KINASE; NITRIC-OXIDE SYNTHASE; OXIDATIVE STRESS;
   DIABETIC CARDIOMYOPATHY; INSULIN-RESISTANCE; HEART-FAILURE; CELL-DEATH;
   MOLECULAR-MECHANISMS; RYANODINE RECEPTOR; METABOLIC SYNDROME
AB Metabolic syndromes (MS) are a cluster of disorders such as obesity, hypertension, dyslipidemia, and diabetes. Cardiometabolic syndrome (CMS), a branch of MS, is a group of diseases affecting cardiovascular, renal, metabolic, prothrombotic, and inflammatory abnormalities due to defects in energy metabolism. Since the emergence of molecular biology and the discovery of pathogenic mitochondrial DNA defect in the 1980s, research advances have revealed a number of common human diseases involving mitochondrial dysfunction. One of the major defects in CMS and its associated diseases is excess cellular oxidative stress and oxidative damage to mitochondrial components. In this study, we overview specific aspects of mitochondrial biology that have contributed and likely will continue enhance the progress of development of therapeutics for CMS. During the last decade, however, increasing evidence has emerged supporting the role of mitochondrial functional parameters in the genesis of various metabolism-related disorders. The biochemical pathways which modulate various mitochondrial functional indicators such as mitochondrial biogenesis, mitochondrial membrane potential, electron transport chain and ATP synthesis, intramitochondrial oxidative stress, and mitochondria-mediated cell death have been recognized in diagnosis and prognosis of various disorders associated with energy metabolism and heart function.
C1 [Anupama, Nair; Sindhu, Ganapathy; Raghu, Kozhiparambil Gopalan] CSIR NIIST, Agroproc & Technol Div, Ind Estate PO, Thiruvananthapuram 695019, Kerala, India.
C3 Council of Scientific & Industrial Research (CSIR) - India; CSIR -
   National Institute Interdisciplinary Science & Technology (NIIST)
RP Raghu, KG (corresponding author), CSIR NIIST, Agroproc & Technol Div, Ind Estate PO, Thiruvananthapuram 695019, Kerala, India.
EM raghukgopal@niist.res.in
RI Raghu, K/AAT-8042-2021
FU CSIR
FX We would like to acknowledge CSIR for financial assistance to conduct
   research on mitochondria and its role in the genesis and prognosis of
   metabolic syndrome.
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NR 86
TC 12
Z9 14
U1 0
U2 8
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0767-3981
EI 1472-8206
J9 FUND CLIN PHARMACOL
JI Fundam. Clin. Pharmacol.
PD AUG
PY 2018
VL 32
IS 4
BP 346
EP 356
DI 10.1111/fcp.12359
PG 11
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA GM3RL
UT WOS:000438025300001
PM 29453877
DA 2025-06-11
ER

PT J
AU Fan, XY
   Wang, YY
   Wang, Y
   Duan, H
   Du, YJ
   Pan, TR
   Zhong, X
AF Fan, Xingyu
   Wang, Yueyue
   Wang, Yue
   Duan, Hao
   Du, Yijun
   Pan, Tianrong
   Zhong, Xing
TI Dapagliflozin attenuates metabolic dysfunction-associated steatotic
   liver disease by inhibiting lipid accumulation, inflammation and liver
   fibrosis
SO BMC PHARMACOLOGY & TOXICOLOGY
LA English
DT Article
DE Dapagliflozin; Metabolic dysfunction-associated steatotic liver disease;
   Lipid accumulation; Inflammation; Oxidative stress; Fibrosis
ID HEPATIC STEATOSIS; AGONISTS
AB BackgroundMetabolic dysfunction-associated steatotic liver disease (MASLD) has emerged as a globally prevalent liver disease, closely linked to the rising incidence of obesity, diabetes, and metabolic syndrome. Dapagliflozin (DaPa), a sodium-glucose cotransporter-2 inhibitor, is primarily prescribed for diabetes management. It has shown potential efficacy in managing MASLD in clinical settings. However, the molecular mechanisms underlying the effects of DaPa on MASLD remain poorly understood. Hence, we aimed to investigate the role of and mechanisms underlying DaPa in MASLD.MethodsMale diet-induced obese (DIO) C57BL/6J mice were injected with streptozotocin (STZ), followed by a high-fat diet regimen to stimulate metabolic dysfunction. Subsequently, they received DaPa via gavage for 5 weeks. Hepatic lipid accumulation, pathological alterations, inflammatory markers, and liver fibrosis were assessed.ResultsDaPa administration reduced liver fat accumulation in DIO mice. Additionally, it decreased oxidative stress and lipid peroxide levels, which was attributed to the upregulation of glutathione and the downregulation of malondialdehyde and reactive oxygen species levels. Notably, DaPa downregulated the inflammatory response and reduced liver fibrosis.ConclusionsDaPa protects against MASLD by inhibiting lipid accumulation, inflammation, oxidative stress, and liver fibrosis.
C1 [Fan, Xingyu; Wang, Yueyue; Wang, Yue; Duan, Hao; Du, Yijun; Pan, Tianrong; Zhong, Xing] Anhui Med Univ, Dept Endocrinol, Affiliated Hosp 2, 678 Furong Rd, Hefei 230601, Anhui, Peoples R China.
   [Fan, Xingyu; Wang, Yueyue; Wang, Yue; Duan, Hao; Du, Yijun; Pan, Tianrong; Zhong, Xing] Anhui Med Univ, Res Ctr Translat Med, Affiliated Hosp 2, 678 Furong Rd, Hefei 230601, Anhui, Peoples R China.
C3 Anhui Medical University; Anhui Medical University
RP Pan, TR; Zhong, X (corresponding author), Anhui Med Univ, Dept Endocrinol, Affiliated Hosp 2, 678 Furong Rd, Hefei 230601, Anhui, Peoples R China.; Pan, TR; Zhong, X (corresponding author), Anhui Med Univ, Res Ctr Translat Med, Affiliated Hosp 2, 678 Furong Rd, Hefei 230601, Anhui, Peoples R China.
EM PanTR1968@163.com; zhongxing761@163.com
FU National Natural Science Foundation of China; Scientific Research and
   Experiment Center of the Second Affiliated Hospital of Anhui Medical
   University
FX We acknowledge the experimental platform provided by the Scientific
   Research and Experiment Center of the Second Affiliated Hospital of
   Anhui Medical University.
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NR 48
TC 0
Z9 0
U1 1
U2 1
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 2050-6511
J9 BMC PHARMACOL TOXICO
JI BMC Pharmacol. Toxicol.
PD MAR 12
PY 2025
VL 26
IS 1
AR 59
DI 10.1186/s40360-025-00898-z
PG 13
WC Pharmacology & Pharmacy; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Toxicology
GA 0DW2W
UT WOS:001445027900001
PM 40075451
OA Green Accepted, gold
DA 2025-06-11
ER

PT J
AU Petranovic, D
   Tyo, K
   Vemuri, GN
   Nielsen, J
AF Petranovic, Dina
   Tyo, Keith
   Vemuri, Goutham N.
   Nielsen, Jens
TI Prospects of yeast systems biology for human health: integrating lipid,
   protein and energy metabolism
SO FEMS YEAST RESEARCH
LA English
DT Review
DE yeast systems biology; energy metabolism; proteostasis
ID ENDOPLASMIC-RETICULUM STRESS; PROGRAMMED CELL-DEATH;
   SACCHAROMYCES-CEREVISIAE; TRANSCRIPTION FACTORS; OXIDIZED PROTEINS;
   UPSTREAM KINASE; GLOBAL ANALYSIS; SNF1 KINASE; GLUCOSE REPRESSION;
   OXIDATIVE STRESS
AB The yeast Saccharomyces cerevisiae is a widely used model organism for studying cell biology, metabolism, cell cycle and signal transduction. Many regulatory pathways are conserved between this yeast and humans, and it is therefore possible to study pathways that are involved in disease development in a model organism that is easy to manipulate and that allows for detailed molecular studies. Here, we briefly review pathways involved in lipid metabolism and its regulation, the regulatory network of general metabolic regulator Snf1 (and its human homologue AMPK) and the proteostasis network with its link to stress and cell death. All the mentioned pathways can be used as model systems for the study of homologous pathways in human cells and a failure in these pathways is directly linked to several human diseases such as the metabolic syndrome and neurodegeneration. We demonstrate how different yeast pathways are conserved in humans, and we discuss the possibilities of using the systems biology approach to study and compare the pathways of relevance with the objective to generate hypotheses and gain new insights.
C1 [Petranovic, Dina; Tyo, Keith; Vemuri, Goutham N.; Nielsen, Jens] Chalmers Univ Technol, Dept Chem & Biol Engn, SE-41296 Gothenburg, Sweden.
C3 Chalmers University of Technology
RP Nielsen, J (corresponding author), Chalmers Univ Technol, Dept Chem & Biol Engn, Kemivagen 10, SE-41296 Gothenburg, Sweden.
EM nielsenj@chalmers.se
RI Tyo, Keith/H-6227-2012; Nielsen, Jens/ABH-7527-2020; Nielsen,
   Jens/Q-1347-2017
OI Nielsen, Jens/0000-0002-9955-6003; Tyo, Keith/0000-0002-2342-0687;
   Petranovic, Dina/0000-0001-8724-3942
FU UNICELLSYS; SYSINBIO; Swedish Research Council; Knut and Alice
   Wallenberg Foundation; Chalmers Foundation
FX Research work carried out by our research group in this field is
   sponsored by UNICELLSYS (http://www.unicellsys.eu), SYSINBIO
   (http://www.sysbio.se/sysinbio), Swedish Research Council, the Knut and
   Alice Wallenberg Foundation and the Chalmers Foundation.
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NR 120
TC 48
Z9 57
U1 1
U2 32
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1567-1356
EI 1567-1364
J9 FEMS YEAST RES
JI FEMS Yeast Res.
PD DEC
PY 2010
VL 10
IS 8
BP 1046
EP 1059
DI 10.1111/j.1567-1364.2010.00689.x
PG 14
WC Biotechnology & Applied Microbiology; Microbiology; Mycology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Microbiology; Mycology
GA 674GR
UT WOS:000283725500009
PM 20977625
DA 2025-06-11
ER

PT J
AU Bose, M
   Oliván, B
   Laferrère, B
AF Bose, Mousumi
   Olivan, Blanca
   Laferrere, Blandine
TI Stress and obesity: the role of the hypothalamic-pituitary-adrenal axis
   in metabolic disease
SO CURRENT OPINION IN ENDOCRINOLOGY DIABETES AND OBESITY
LA English
DT Article
DE cortisol; hypothalamic-pituitary-adrenal axis; metabolic syndrome;
   obesity
ID 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1; DEXAMETHASONE SUPPRESSION
   TEST; BODY-FAT DISTRIBUTION; ADIPOSE-TISSUE; RISK-FACTORS; ABDOMINAL
   OBESITY; CUSHINGS-SYNDROME; SLEEP DURATION; SERUM LEPTIN;
   SOCIOECONOMIC-STATUS
AB Purpose of review
   Chronic stress, combined with positive energy balance, may be a contributor to the increased risk for obesity, especially upper body obesity, and other metabolic diseases. This association may be mediated by alterations in the hypothalamic-pituitary-adrenal (HPA) axis. In this review, we summarize the major research that has been conducted on the role of the HPA axis in obesity and metabolic disease.
   Recent findings
   Dysregulation in the HPA axis has been associated with upper body obesity, but data are inconsistent, possibly due to methodological differences across studies. In addition to systemic effects, changes in local cortisol metabolism in adipose tissue may also influence the risk for obesity. HPA axis dysregulation may be the causal link between conditions such as maternal malnutrition and sleep deprivation with metabolic disease.
   Summary
   The present review provides evidence for the relationship between chronic stress, alterations in HPA activity, and obesity. Understanding these associations and its interactions with other factors will be important in developing effective treatments for obesity and related metabolic diseases.
C1 [Bose, Mousumi; Olivan, Blanca; Laferrere, Blandine] Columbia Univ Coll Phys & Surg, St Lukes Roosevelt Hosp Ctr, New York Obes Res Ctr, New York, NY 10025 USA.
C3 Columbia University; Mount Sinai West; Mount Sinai St. Luke's
RP Bose, M (corresponding author), Columbia Univ Coll Phys & Surg, St Lukes Roosevelt Hosp Ctr, New York Obes Res Ctr, 1111 Amsterdam Ave,Room 1034, New York, NY 10025 USA.
EM mb3103@columbia.edu
FU National Institute of Health [DK07559]
FX The present work was funded by National Institute of Health training
   grant #DK07559.
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NR 108
TC 244
Z9 307
U1 1
U2 30
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1752-296X
EI 1752-2978
J9 CURR OPIN ENDOCRINOL
JI Curr. Opin. Endocrinol. Diabetes Obes.
PD OCT
PY 2009
VL 16
IS 5
BP 340
EP 346
DI 10.1097/MED.0b013e32832fa137
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 691CF
UT WOS:000285057200002
PM 19584720
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Malcher-Lopes, R
   Di, S
   Marcheselli, VS
   Weng, FJ
   Stuart, CT
   Bazan, NG
   Tasker, JG
AF Malcher-Lopes, Renato
   Di, Shi
   Marcheselli, Victor S.
   Weng, Feng-Ju
   Stuart, Christopher T.
   Bazan, Nicolas G.
   Tasker, Jeffrey G.
TI Opposing crosstalk between leptin and glucocorticoids rapidly modulates
   synaptic excitation via endocannabinoid release
SO JOURNAL OF NEUROSCIENCE
LA English
DT Article
DE leptin; glucocorticoids; endocannabinoids; neuroendocrine; stress;
   energy homeostasis
ID PITUITARY-ADRENAL AXIS; OBESE ZUCKER RAT; PARAVENTRICULAR NUCLEUS;
   RECEPTOR IMMUNOREACTIVITY; METABOLIC SYNDROME; ENERGY-BALANCE; OXYTOCIN;
   INSULIN; NEURONS; STIMULATION
AB The hypothalamic paraventricular nucleus (PVN) integrates preautonomic and neuroendocrine control of energy homeostasis, fluid balance, and the stress response. We recently demonstrated that glucocorticoids act via a membrane receptor to rapidly cause endocannabinoid-mediated suppression of synaptic excitation in PVN neurosecretory neurons. Leptin, a major signal of nutritional state, suppresses CB1 cannabinoid receptor-dependent hyperphagia (increased appetite) in fasting animals by reducing hypothalamic levels of endocannabinoids. Here we show that glucocorticoids stimulate endocannabinoid biosynthesis and release via a G alpha(s)-cAMP protein kinase A-dependent mechanism and that leptin blocks glucocorticoid-induced endocannabinoid biosynthesis and suppression of excitation in the PVN via a phosphodiesterase-3B-mediated reduction in intracellular cAMP levels. We demonstrate this rapid hormonal interaction in both PVN magnocellular and parvocellular neurosecretory cells. Leptin blockade of the glucocorticoid-induced, endocannabinoid-mediated suppression of excitation was absent in leptin receptor-deficient obese Zucker rats. Our findings reveal a novel hormonal crosstalk that rapidly modulates synaptic excitation via endocannabinoid release in the hypothalamus and that provides a nutritional state-sensitive mechanism to integrate the neuroendocrine regulation of energy homeostasis, fluid balance, and the stress response.
C1 Tulane Univ, Neurosci Program, New Orleans, LA 70118 USA.
   Tulane Univ, Neurobiol Div, Dept Cell & Mol Biol, New Orleans, LA 70118 USA.
   Tulane Univ, Mol Neurobiol Core Lab, New Orleans, LA 70118 USA.
   Louisiana State Univ, Hlth Sci Ctr, Neurosci Ctr Excellence, New Orleans, LA 70112 USA.
C3 Tulane University; Tulane University; Tulane University; Louisiana State
   University System; Louisiana State University Health Sciences Center New
   Orleans
RP Malcher-Lopes, R (corresponding author), Ecole Polytech Fed Lausanne, Brain Mind Inst, Neural Microcircuitry Lab, CH-1015 Lausanne, Switzerland.
EM malcherlopes@gmail.com
RI Bazan, Nicolas/AAN-4121-2020; Malcher-Lopes, Renato/I-5170-2015; Tasker,
   Jeffrey/J-4879-2014
OI Malcher-Lopes, Renato/0000-0002-4941-9908
FU NCRR NIH HHS [P20RR016816] Funding Source: Medline; NIMH NIH HHS
   [MH066958] Funding Source: Medline; NINDS NIH HHS [NS23002] Funding
   Source: Medline
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NR 60
TC 209
Z9 235
U1 0
U2 8
PU SOC NEUROSCIENCE
PI WASHINGTON
PA 11 DUPONT CIRCLE, NW, STE 500, WASHINGTON, DC 20036 USA
SN 0270-6474
EI 1529-2401
J9 J NEUROSCI
JI J. Neurosci.
PD JUN 14
PY 2006
VL 26
IS 24
BP 6643
EP 6650
DI 10.1523/JNEUROSCI.5126-05.2006
PG 8
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 054KQ
UT WOS:000238375900029
PM 16775153
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Egido, J
   Ruiz-Ortega, M
AF Egido, Jesus
   Ruiz-Ortega, Marta
TI Anti-inflammatory actions of quinapril
SO CARDIOVASCULAR DRUGS AND THERAPY
LA English
DT Review
DE accupril; inflammation; renal disease; atherosclerosis; arthritis;
   inflammation; C-reactive protein; scleroderma; metabolic syndrome
ID ANGIOTENSIN-CONVERTING-ENZYME; FACTOR-KAPPA-B; SPONTANEOUSLY
   HYPERTENSIVE-RATS; LEFT-VENTRICULAR HYPERTROPHY; IMMUNE-COMPLEX
   NEPHRITIS; CELL-ADHESION MOLECULE-1; SMOOTH-MUSCLE-CELLS; CHRONIC
   HEART-FAILURE; INHIBITOR QUINAPRIL; OXIDATIVE STRESS
AB Objective The role of angiotensin II (Ang-II) in inflammation and the mechanisms through which it exerts this role are explored. Signaling through angiotensin stimulation of inflammatory cells often amplifies inflammation. Formation of Ang-II from tissue angiotensin-converting enzyme (ACE) has been shown to be of greater importance in the development and progression of inflammatory diseases than plasma ACE.
   Conclusion Quinapril, which is a potent and selective inhibitor of both plasma and tissue ACE, has demonstrated anti-inflammatory properties in many disease states such as atherosclerosis, nephritis, scleroderma, diabetes and arthritis, and, thus, offers new therapeutic possibilities for disease treatment.
C1 Univ Autonoma Madrid, Vasc & Renal Lab, Fdn Jimenez Diaz, Madrid, Spain.
C3 Autonomous University of Madrid
RP Egido, J (corresponding author), Univ Autonoma Madrid, Vasc & Renal Lab, Fdn Jimenez Diaz, Avda Reyes Catolicos 2, Madrid, Spain.
EM jegido@fjd.es
RI Ruiz-Ortega, Marta/D-3584-2012; ruiz-ortega, marta/D-3584-2012
OI Ruiz-Ortega, Marta/0000-0002-1495-6535; ruiz-ortega,
   marta/0000-0002-1403-2690
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NR 87
TC 6
Z9 6
U1 1
U2 5
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0920-3206
EI 1573-7241
J9 CARDIOVASC DRUG THER
JI Cardiovasc. Drugs Ther.
PD JUN
PY 2007
VL 21
IS 3
BP 211
EP 220
DI 10.1007/s10557-007-6019-1
PG 10
WC Cardiac & Cardiovascular Systems; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Pharmacology & Pharmacy
GA 171WE
UT WOS:000246765300008
PM 17404826
DA 2025-06-11
ER

PT J
AU García-Carrasco, M
   Mendoza-Pinto, C
   Munguía-Realpozo, P
   Etchegaray-Morales, I
   Vélez-Pelcastre, SK
   Méndez-Martínez, S
   Zamora-Ginez, I
   de Lara, LGV
   Gálvez-Romero, JL
   Escamilla-Márquez, M
AF Garcia-Carrasco, Mario
   Mendoza-Pinto, Claudia
   Munguia-Realpozo, Pamela
   Etchegaray-Morales, Ivet
   Velez-Pelcastre, Sandra Karina
   Mendez-Martinez, Socorro
   Zamora-Ginez, Irma
   de Lara, Luis Guillermo Vazquez
   Galvez-Romero, Jose Luis
   Escamilla-Marquez, Marco
TI Insulin Resistance and Diabetes Mellitus in Patients with Systemic Lupus
   Erythematosus
SO ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS
LA English
DT Review
DE Systemic lupus erythematosus; insulin resistance; diabetes mellitus;
   T2DM; autoimmune disease; prediabetes
ID BETA-CELL FUNCTION; HOMEOSTASIS MODEL ASSESSMENT; RISK-FACTORS;
   RHEUMATOID-ARTHRITIS; METABOLIC SYNDROME; OXIDATIVE STRESS;
   CARDIOVASCULAR-DISEASE; MOUSE MODEL; GLUCOSE; ASSOCIATION
AB Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by damage to multiple systems and a higher risk of cardiovascular disease. In addition, several studies have found that insulin resistance (IR) is more prevalent in SLE patients than controls, increasing the risk of prediabetes, type 2 diabetes mellitus (T2DM) and morbidity. The objective of this review article was to summarize the most relevant evidence about the relationship among IR, T2DM and SLE, including the effects of pro-inflammatory states, acute-phase proteins, pro-inflammatory cytokines, and pharmacological SLE treatment. A better understanding of the mechanisms involved in these comorbidities will allow better treatment strategies.
C1 [Garcia-Carrasco, Mario; Mendoza-Pinto, Claudia; Munguia-Realpozo, Pamela; Etchegaray-Morales, Ivet; Velez-Pelcastre, Sandra Karina] Meritorious Autonomous Univ Puebla, Med Sch, Dept Rheumatol, Puebla, Mexico.
   [Mendoza-Pinto, Claudia] Specialties Hosp UMAE, Mexican Social Secur Inst, Syst Autoimmune Dis Res Unit, Puebla, Mexico.
   [Mendez-Martinez, Socorro] Mexican Social Secur Inst, Res Hlth Coordinat, Puebla, Mexico.
   [Zamora-Ginez, Irma] Meritorious Autonomous Univ Puebla, Med Sch, Med Sci & Res, Puebla, Mexico.
   [de Lara, Luis Guillermo Vazquez] Meritorious Autonomous Univ Puebla, Med Sch, Lab Expt Med, Puebla, Mexico.
   [Galvez-Romero, Jose Luis] Inst Seguridad & Serv Sociales Trabajadores Estad, Hosp Reg, Res Dept, Puebla, Mexico.
   [Escamilla-Marquez, Marco] Meritorious Autonomous Univ Puebla, Med Sch, Dept Endocrinol, Puebla, Mexico.
C3 Benemerita Universidad Autonoma de Puebla; Instituto Mexicano del Seguro
   Social; Instituto Mexicano del Seguro Social; Benemerita Universidad
   Autonoma de Puebla; Benemerita Universidad Autonoma de Puebla;
   Benemerita Universidad Autonoma de Puebla
RP García-Carrasco, M (corresponding author), Meritorious Autonomous Univ Puebla, Med Sch, Dept Rheumatol, 13 Sur 2702, Puebla 72420, Mexico.
EM pamela.munguia@yahoo.com.mx
RI Mendoza, Claudia/LDF-4677-2024; Munguía, Pamela/LDF-4682-2024; MARTINEZ,
   SOCORRO/AAH-5080-2020; Etchegaray, Ivet/JRX-0115-2023; Zamora-Ginez,
   Irma/AEI-8729-2022
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NR 98
TC 13
Z9 13
U1 5
U2 8
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1871-5303
EI 2212-3873
J9 ENDOCR METAB IMMUNE
JI Endocr. Metab. Immune Disord.-Drug Targets
PY 2023
VL 23
IS 4
BP 503
EP 514
DI 10.2174/1871530322666220908154253
PG 12
WC Endocrinology & Metabolism; Immunology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Immunology; Pharmacology & Pharmacy
GA I8WD8
UT WOS:001005522900010
PM 36089781
DA 2025-06-11
ER

PT J
AU Sung, SH
   Moon, JY
   Choi, SJ
AF Sung, Sook Hee
   Moon, Ji Young
   Choi, Seung Jin
TI Association of Metabolic Syndrome With Serum Uric Acid Level in Male
   Workers
SO JOURNAL OF ENDOCRINOLOGY AND METABOLISM
LA English
DT Article
DE Uric acid; Metabolic syndrome; Inflammation; Odds ratio; Worker;
   Hypertriglyceridemia
ID CARDIOVASCULAR-DISEASE; INDEPENDENT PREDICTOR; CHOLESTEROL RATIO;
   OXIDATIVE STRESS; OBESITY; HYPERURICEMIA; HYPERTENSION; INSULIN; RISK;
   ACCUMULATION
AB Background: Metabolic syndrome (MetS) is a type of the inflammatory diseases that is a known risk factor for many conditions, including type 2 diabetes mellitus (DM) and cardiovascular disease (CVD). Preventing or managing of MetS involves biomarkers for early identification or predicting the risk of developing the condition. The as-sociation between serum uric acid (SUA) and MetS in a large popula-tion of Korean male workers was investigated.Methods: We conducted a cross-sectional study of 9,191 male workers who comprised 6,626 daytime workers (DW) and 2,565 shift workers (SW) aged 20 -58 years who had undergone regular health check-up in 2021. Body mass index (BMI), waist circumference (WC), blood pressure (BP), white blood cell count (WBC), biochemical parameters including SUA, liver enzymes, lipid profile and se-rum creatinine (Cr) were measured and participants responded to a questionnaire on health-related behavior. Participants were placed in quartiles based on their SUA levels. Associations between SUA and the prevalence of MetS or metabolic components (MS) were explored using multiple logistic regression analysis.Results: The overall prevalence of MetS was 24.6%, and the prevalence of MetS in DW was significantly higher than in SW (25.8% vs. 21.7%, P = 0.001). The prevalence of MetS, number of MS, and number of SW were positively correlated with SUA levels, as were all other variables except age, high-density lipoprotein cholesterol (HDL-C) and prevalence of DM, which were negatively correlated with SUA levels. After adjusting for multiple potential confounders, the odds ratio (OR) for MetS of the highest SUA quartile compared to the reference was 1.86 (95% confidence interval (CI): 1.60 -2.15); however, after adjusting for BMI, it was 1.32 (95% CI: 1.12 -1.54). The SUA level was also associated with high BP, high fasting plasma glucose (FPG) and hypertriglyceridemia after full adjustment. Notably, hypertriglyceridemia was also associated with a high-normal SUA level.Conclusions: SUA levels may be independent predictors of MetS in Korean male workers. Hypertriglyceridemia is closely associated with SUA levels.
C1 [Sung, Sook Hee; Moon, Ji Young; Choi, Seung Jin] Korea Hydro & Nucl Power Co Ltd, Radiat Hlth Inst, Hlth & Med Sect, Seoul 04505, South Korea.
C3 Korea Hydro & Nuclear Power
RP Choi, SJ (corresponding author), Korea Hydro & Nucl Power Co Ltd, Radiat Hlth Inst, Hlth & Med Sect, Seoul 04505, South Korea.
EM sjchoice@naver.com
FU Korea Hydro & Nuclear Power project [A23LF01]
FX The study was supported by a grant from the Korea Hydro & Nuclear Power
   project (A23LF01) .
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NR 67
TC 0
Z9 0
U1 0
U2 2
PU ELMER PRESS INC
PI Ontario
PA 9225 LESLIE ST, STE 201, Ontario, RICHMOND HILL, CANADA
SN 1923-2861
EI 1923-287X
J9 J ENDOCRINOL METAB
JI J. Endocrinol. Metab.
PD FEB
PY 2024
VL 14
IS 1
BP 21
EP 32
DI 10.14740/jem927
EA JAN 2024
PG 12
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA KQ2Y4
UT WOS:001146433200001
OA gold
DA 2025-06-11
ER

PT J
AU Saha, S
   Pal, D
   Nimse, SB
AF Saha, Supriyo
   Pal, Dilipkumar
   Nimse, Satish Balasaheb
TI Indazole Derivatives Effective against Gastrointestinal Diseases
SO CURRENT TOPICS IN MEDICINAL CHEMISTRY
LA English
DT Review
DE Indazole; Irritable bowel syndrome; Ulcerative colitis; Diarrhea;
   Gastrointestinal cancer; Metabolic syndrome
ID HYDROXYACETAMIDE DERIVATIVES; ANTIPROLIFERATIVE ACTIVITY; INHIBITORS;
   DISCOVERY; DESIGN; CELL; GRANISETRON; REDUCTION; POTENT; MICE
AB Background: In this fast-growing lifestyle, humans are in the race against time to cope up with busy schedule. Less exercise, consumption of high calorie-low fiber food and stress take us one step closer towards digestive dysfunction. Dysfunctional digestive system causes various gastrointestinal disorders like constipation, IBS, UC, diarrhea, gastrointestinal tract immobility, hyperglycemia, hemorrhoids, fistula, anal fissures, stomach cancer, hepatocellular carcinoma, pancreatic cancer, colon cancer and metabolic syndrome. Amongst various natural and synthetic indazole derivatives nigellicine, nigellamine, nigellidine, zanubrutinib and SCH772984 showed prominent results to cure various gastrointestinal disorders. Objectives: In this manuscript, we focus on the importance of indazole derivatives in the treatment of various gastrointestinal diseases. Results and Conclusion: In the treatment of IBS, four positions (R-1, R-2, R-3 and R-4) of indazole were mainly substituted with aromatic aldehyde/substituted methyl, aromatic acid/formamide, benzamide/sulfonamide and methyl groups, respectively. In case of diarrhea and metabolic syndrome treatment, substitutions with benzyl/isopropyl/acetaldehyde (R-1 position) and carboxamide/formamide (R-2 position) of indazole play a critical role. Also, in the treatment of diabetes melitus, all six positions of indazole derivative were substituted with substituted aryl/alkyl/aromatic acid, substituted formamide, substituted acetamide/hydrazide group, halo aryl, substituted aryl/aromatic acid and a long chain of alkyl-aryl alcohol groups, respectively. In the treatment of gastrointestinal cancers, all six positions of indazole derivative were substituted with benzylamide (R-1), octanediamide/benzamide/formamide (R-2), carbaldehyde (R-4) and substituted phenyl (R-5 and R-6) groups, respectively. Six receptors (6NP0, 2YME, 4EFU, 4WZ8, 5U4W and 7KKP) associated with GI disorders (co-crystallized with indazole derivative) were identified. Analysis of the receptors showed that co-crystalized ligand molecules were well-interacted with receptors via pie-pie interaction, co-ordinate and sigma bonding within 4 angstrom distance. As per Ramachandran plot analysis, more than 90% of the amino acid residues were present in the most favored region. So, if sufficient focuses are imposed on the development of newer indazole derivatives to treat gastrointestinal diseases, it will work as a boon to society.
C1 [Saha, Supriyo] Sardar Bhagwan Singh Univ, Sch Pharmaceut Sci & Technol, Dehra Dun 248161, Uttarakhand, India.
   [Pal, Dilipkumar] Guru Ghasidas Vishwavidyalaya, Dept Pharmaceut Sci, Bilaspur 495009, CG, India.
   [Nimse, Satish Balasaheb] Hallym Univ, Inst Appl Chem, Chunchon 200702, South Korea.
   [Nimse, Satish Balasaheb] Hallym Univ, Dept Chem, Chunchon 200702, South Korea.
C3 Guru Ghasidas Vishwavidyalaya; Hallym University; Hallym University
RP Saha, S (corresponding author), Sardar Bhagwan Singh Univ, Sch Pharmaceut Sci & Technol, Dehra Dun 248161, Uttarakhand, India.
EM supriyo9@gmail.com
RI Pal, Dilipkumar/IQU-0568-2023; Nimse, Satish/I-6590-2013; SAHA,
   SUPRIYO/AAF-6206-2020
OI SAHA, SUPRIYO/0000-0003-1365-4698; Nimse, Satish
   Balasaheb/0000-0002-5137-0584; Pal, Dilipkumar/0000-0002-9623-1617
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NR 58
TC 6
Z9 6
U1 0
U2 5
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1568-0266
EI 1873-4294
J9 CURR TOP MED CHEM
JI Curr. Top. Med. Chem.
PY 2022
VL 22
IS 14
BP 1189
EP 1214
DI 10.2174/1568026621666211209155933
PG 26
WC Chemistry, Medicinal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 3Z5EQ
UT WOS:000844440500006
PM 34886775
DA 2025-06-11
ER

PT J
AU Orabi, D
   Berger, NA
   Brown, JM
AF Orabi, Danny
   Berger, Nathan A.
   Brown, J. Mark
TI Abnormal Metabolism in the Progression of Nonalcoholic Fatty Liver
   Disease to Hepatocellular Carcinoma: Mechanistic Insights to
   Chemoprevention
SO CANCERS
LA English
DT Review
DE nonalcoholic fatty liver disease; nonalcoholic steatohepatitis;
   hepatocellular carcinoma; PPAR; bile acids; gut microbiome; autophagy
ID ACTIVATED RECEPTOR-ALPHA; GLUCAGON-LIKE PEPTIDE-1; IMPROVES INSULIN
   SENSITIVITY; COA CARBOXYLASE INHIBITION; REDUCES HEPATIC STEATOSIS;
   TYPE-2 DIABETES-MELLITUS; INDEPENDENT RISK-FACTOR; PPAR-ALPHA; OXIDATIVE
   STRESS; UNITED-STATES
AB Simple Summary Nonalcoholic fatty liver disease (NAFLD) is a disorder of excess lipid accumulation within the liver. Rates of NAFLD have rapidly increased with the sudden rise in obesity and metabolic syndrome. NAFLD may lead to liver inflammation, fibrosis, and dysfunction, and in select cases, the development of liver cancer in the form of hepatocellular carcinoma (HCC). NAFLD is established as a leading cause of liver cancer, and its contribution is expected to grow. Abnormal hepatic lipid metabolism has been repeatedly associated with the progression of NAFLD to primary liver cancer. The current treatment of NAFLD is focused primarily on reducing liver inflammation and fibrosis. Using therapies that additionally target metabolic or lipid signaling pathways that are responsible for tumor development may work to reduce the risk of liver cancer in these patients. Nonalcoholic fatty liver disease (NAFLD) is on the rise and becoming a major contributor to the development of hepatocellular carcinoma (HCC). Reasons for this include the rise in obesity and metabolic syndrome in contrast to the marked advances in prevention and treatment strategies of viral HCC. These shifts are expected to rapidly propel this trend even further in the coming decades, with NAFLD on course to become the leading etiology of end-stage liver disease and HCC. No Food and Drug Administration (FDA)-approved medications are currently available for the treatment of NAFLD, and advances are desperately needed. Numerous medications with varying mechanisms of action targeting liver steatosis and fibrosis are being investigated including peroxisome proliferator-activated receptor (PPAR) agonists and farnesoid X receptor (FXR) agonists. Additionally, drugs targeting components of metabolic syndrome, such as antihyperglycemics, have been found to affect NAFLD progression and are now being considered in the treatment of these patients. As NAFLD drug discovery continues, special attention should be given to their relationship to HCC. Several mechanisms in the pathogenesis of NAFLD have been implicated in hepatocarcinogenesis, and therapies aimed at NAFLD may additionally harbor independent antitumorigenic potential. This approach may provide novel prevention and treatment strategies.
C1 [Orabi, Danny; Brown, J. Mark] Cleveland Clin, Dept Cardiovasc & Metab Sci, Lerner Res Inst, Cleveland, OH 44106 USA.
   [Orabi, Danny; Brown, J. Mark] Cleveland Clin, Ctr Microbiome & Human Hlth, Lerner Res Inst, Cleveland, OH 44106 USA.
   [Orabi, Danny; Brown, J. Mark] Case Western Reserve Univ, Dept Mol Med, Cleveland Clin, Lerner Coll Med, Cleveland, OH 44195 USA.
   [Orabi, Danny; Berger, Nathan A.; Brown, J. Mark] Case Comprehens Canc Ctr, Cleveland, OH 44106 USA.
   [Orabi, Danny] Cleveland Clin, Dept Gen Surg, Cleveland, OH 44195 USA.
   [Berger, Nathan A.] Case Western Reserve Univ, Dept Med, Sch Med, Cleveland, OH 44106 USA.
   [Berger, Nathan A.] Case Western Reserve Univ, Dept Biochem, Sch Med, Cleveland, OH 44106 USA.
   [Berger, Nathan A.] Case Western Reserve Univ, Dept Genet & Genome Sci, Sch Med, Cleveland, OH 44106 USA.
C3 Cleveland Clinic Foundation; Cleveland Clinic Foundation; Cleveland
   Clinic Foundation; University System of Ohio; Case Western Reserve
   University; University System of Ohio; Case Western Reserve University;
   Cleveland Clinic Foundation; University System of Ohio; Case Western
   Reserve University; University System of Ohio; Case Western Reserve
   University; University System of Ohio; Case Western Reserve University
RP Brown, JM (corresponding author), Cleveland Clin, Dept Cardiovasc & Metab Sci, Lerner Res Inst, Cleveland, OH 44106 USA.; Brown, JM (corresponding author), Cleveland Clin, Ctr Microbiome & Human Hlth, Lerner Res Inst, Cleveland, OH 44106 USA.; Brown, JM (corresponding author), Case Western Reserve Univ, Dept Mol Med, Cleveland Clin, Lerner Coll Med, Cleveland, OH 44195 USA.; Brown, JM (corresponding author), Case Comprehens Canc Ctr, Cleveland, OH 44106 USA.
EM orabid@ccf.org; nab@case.edu; brownm5@ccf.org
FU National Institutes of Health [R01DK120679, P50 AA024333, P01 HL147823,
   P50 CA150964, P30 CA043703]; National Cancer Institute [P50CA150964]
   Funding Source: NIH RePORTER
FX This work was supported in part by National Institutes of Health grants
   R01DK120679 (J.M.B.), P50 AA024333 (J.M.B.), P01 HL147823 (J.M.B.), P50
   CA150964 (N.A.B.), and P30 CA043703 (N.A.B.).
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NR 257
TC 16
Z9 16
U1 0
U2 24
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6694
J9 CANCERS
JI Cancers
PD JUL
PY 2021
VL 13
IS 14
AR 3473
DI 10.3390/cancers13143473
PG 25
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA TN3WQ
UT WOS:000676169300001
PM 34298687
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU El-Bassossy, HM
   Elberry, AA
   Ghareib, SA
AF El-Bassossy, Hany M.
   Elberry, Ahmed A.
   Ghareib, Salah A.
TI Geraniol improves the impaired vascular reactivity in diabetes and
   metabolic syndrome through calcium channel blocking effect
SO JOURNAL OF DIABETES AND ITS COMPLICATIONS
LA English
DT Article
DE Geraniol; Diabetes; Vascular reactivity; Nitric oxide; Advanced
   glycation end products; Calcium channels
ID RAT THORACIC AORTA; NF-KAPPA-B; SMOOTH-MUSCLE; CONTRACTILE RESPONSES;
   POTASSIUM CHANNELS; INSULIN-RESISTANCE; OXIDATIVE STRESS; ESSENTIAL OIL;
   END-PRODUCTS; COMPLICATIONS
AB Aim: The aim of the present study is to investigate the effect and possible mechanism of action of geraniol on the impaired vascular reactivity of aortic rings isolated from diabetes or metabolic syndrome (MS)-induced rats.
   Methods: Male Wistar rats were divided into control, type 1 diabetes and metabolic syndrome (MS) groups. Diabetes was induced by a single intraperitoneal injection of streptozotocin (50 mg/kg) and left for 10 weeks to develop vascular complications. MS was induced by adding 10% fructose and 3% salt to water and diet for 12 weeks. The present study investigated the effect of in vitro incubation with geraniol (10-300 mu M) on the vasoconstrictor response to phenylephrine (PE) and the vasodilator response to acetylcholine (ACh) as well as its effect on aortae incubated with methylglyoxal (MG) as an advanced glycation end product (AGE). To investigate the mechanism of action of geraniol, different blockers are used, including N omega-nitro-L-arginine methyl ester hydrochloride (L-NAME, 100 mu M), tetraethylammonium chloride (TEA, 10 mM), and indomethacin (1NDO, 5 mu M). Moreover, the effect of calcium chloride (CaCl2) on aortic rings precontracted with PE or potassium chloride (KCl) was examined.
   Results: Thirty minutes incubation with geraniol alleviated the exaggerated vasoconstriction in aortae isolated from diabetic or MS animals or in vitro exposed to MG in a concentration-dependent manner. In addition, geraniol improved the vasodilatation response of diabetic or MS aortae or aortae exposed to MG. In search for the mechanism; geraniol produced concentration-dependent relaxation of both PE and KCl-precontracted aorta. Geraniol relaxation was not affected by L-NAME, INDO or TEA. However, geraniol significantly inhibited voltage dependent and receptor mediated Ca2+-induced contraction activated by KCl or PE respectively.
   Conclusion: In conclusion, geraniol ameliorates impaired vascular reactivity in experimentally induced diabetes and MS. The effect may be partially attributed to an endothelium-independent pathway involving blockage of both voltage dependent and receptor operated calcium channel. (C) 2016 Elsevier Inc. All rights reserved.
C1 [El-Bassossy, Hany M.; Ghareib, Salah A.] King Abdulaziz Univ, Fac Pharm, Dept Pharmacol & Toxicol, Jeddah, Saudi Arabia.
   [El-Bassossy, Hany M.] Zagazig Univ, Fac Pharm, Dept Pharmacol, Zagazig, Egypt.
   [Elberry, Ahmed A.] King Abdulaziz Univ, Fac Pharm, Dept Clin Pharm, Jeddah 21589, Saudi Arabia.
   [Elberry, Ahmed A.] Beni Suef Univ, Fac Med, Dept Clin Pharmacol, Bani Suwayf, Egypt.
C3 King Abdulaziz University; Egyptian Knowledge Bank (EKB); Zagazig
   University; King Abdulaziz University; Egyptian Knowledge Bank (EKB);
   Beni Suef University
RP Elberry, AA (corresponding author), King Abdulaziz Univ, Fac Pharm, Dept Clin Pharm, Jeddah 21589, Saudi Arabia.
EM berry_ahmed@yahoo.com
RI Atteiah, salah/I-1537-2012; El-Bassossy, Hany/NKQ-3705-2025; Elberry,
   Ahmed/I-1539-2012; El-Bassossy, Hany/I-1576-2012
OI Ghareib, Salah/0009-0005-5718-321X; Elberry, Ahmed/0000-0002-0073-3066;
   El-Bassossy, Hany/0000-0002-6838-6945
FU National Plan for Science, Technology and Innovation (MAARIFAH) - King
   Abdulaziz City for Science and Technology - Saudi Arabia
   [12-MED-3063-03]
FX The authors acknowledge with thanks the Science and Technology Unit,
   King Abdulaziz University for technical support. This project was funded
   by the National Plan for Science, Technology and Innovation (MAARIFAH) -
   King Abdulaziz City for Science and Technology - Saudi Arabia - award
   number (12-MED-3063-03). The authors also, would like to thank Mr. Islam
   Farouk, Department of Pharmacology and Toxicology, Faculty of Pharmacy,
   King Abdulaziz University, Jeddah, Saudi Arabia, for his effort and help
   in the experimental study.
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NR 40
TC 41
Z9 42
U1 0
U2 18
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1056-8727
EI 1873-460X
J9 J DIABETES COMPLICAT
JI J. Diabetes Complications
PD AUG
PY 2016
VL 30
IS 6
BP 1008
EP 1016
DI 10.1016/j.jdiacomp.2016.04.006
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA DS2FY
UT WOS:000380579000006
PM 27131411
DA 2025-06-11
ER

PT J
AU Kantapan, J
   Katsube, T
   Wang, B
AF Kantapan, Jiraporn
   Katsube, Takanori
   Wang, Bing
TI High-Fat Diet and Altered Radiation Response
SO BIOLOGY-BASEL
LA English
DT Review
DE radiosensitivity/susceptibility; high-fat diets; reactive oxygen species
   (ROS); inflammation; DNA damage; radiation
ID NF-KAPPA-B; BODY GAMMA-IRRADIATION; NITRIC-OXIDE SYNTHASE; INDUCED
   OBESITY; INSULIN-RESISTANCE; ADIPOSE-TISSUE; HEMATOPOIETIC STEM;
   IONIZING-RADIATION; OXIDATIVE STRESS; MATERNAL OBESITY
AB High-fat diets (HFDs) have become increasingly prevalent in modern societies, driving rising rates of obesity and metabolic syndrome. Concurrently, radiation exposure from medical treatments and environmental sources poses health risks shaped by both biological and environmental factors. This review explores the intersection between HFDs and radiation sensitivity/susceptibility, focusing on how diet-induced metabolic alterations influence the body's response to radiation. Evidence from preclinical and clinical studies indicates that HFDs significantly alter metabolism, leading to increased oxidative stress and immune system dysregulation. These metabolic changes can exacerbate radiation-induced oxidative stress, inflammation, and DNA damage, potentially increasing radiation sensitivity in normal tissues. Conversely, obesity and HFD-induced metabolic disruptions may activate cellular pathways involved in DNA repair, cell survival, and inflammatory responses, fostering tumor resistance and modifying the tumor microenvironment, which may impair the efficacy of radiation therapy in cancer treatment. Understanding the interplay between diet and radiation exposure is critical for optimizing public health guidelines and improving therapeutic outcomes. These findings underscore the need for further research into dietary interventions that may mitigate radiation-associated risks.
C1 [Kantapan, Jiraporn] Chiang Mai Univ, Fac Associated Med Sci, Dept Radiol Technol, Mol Imaging & Therapy Res Unit, Chiang Mai 50200, Thailand.
   [Katsube, Takanori; Wang, Bing] Natl Inst Quantum Sci & Technol QST, Inst Radiol Sci, Chiba 2638555, Japan.
C3 Chiang Mai University; National Institutes for Quantum Science &
   Technology
RP Kantapan, J (corresponding author), Chiang Mai Univ, Fac Associated Med Sci, Dept Radiol Technol, Mol Imaging & Therapy Res Unit, Chiang Mai 50200, Thailand.; Wang, B (corresponding author), Natl Inst Quantum Sci & Technol QST, Inst Radiol Sci, Chiba 2638555, Japan.
EM jiraporn.kan@cmu.ac.th; katsube.takanori@qst.go.jp; wang.bing@qst.go.jp
RI kantapan, jiraporn/AAD-4987-2022
FU Japan Society for the Promotion of Science (JSPS) KAKENHI, Grant-in-Aid
   for Scientific Research (C) [JP22K12387, JP23K11431]; Japan Society for
   the Promotion of Science (JSPS) KAKENHI
FX This work was partially supported by Japan Society for the Promotion of
   Science (JSPS) KAKENHI, Grant-in-Aid for Scientific Research (C), Grant
   Numbers JP22K12387 and JP23K11431.
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NR 230
TC 0
Z9 0
U1 0
U2 0
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2079-7737
J9 BIOLOGY-BASEL
JI Biology-Basel
PD MAR 22
PY 2025
VL 14
IS 4
AR 324
DI 10.3390/biology14040324
PG 44
WC Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics
GA 1ZL6H
UT WOS:001477315300001
PM 40282189
OA gold
DA 2025-06-11
ER

PT J
AU Nematisouldaragh, D
   Kirshenbaum, E
   Uzonna, M
   Kirshenbaum, L
   Rabinovich-Nikitin, I
AF Nematisouldaragh, Darya
   Kirshenbaum, Eryn
   Uzonna, Michael
   Kirshenbaum, Lorrie
   Rabinovich-Nikitin, Inna
TI The Role of Retinoic-Acid-Related Orphan Receptor (RORs) in Cellular
   Homeostasis
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE ROR; cell death; autophagy; mitochondria; cardiovascular disease;
   inflammation; ROS
ID NUCLEAR RECEPTOR; OXIDATIVE STRESS; GAMMA EXPRESSION; DNA-DAMAGE;
   MARESIN 1; ALPHA; MELATONIN; CELLS; DIFFERENTIATION; AUTOPHAGY
AB Retinoic-acid-related orphan receptors (RORs) are transcription factors belonging to the nuclear receptor subfamily consisting of ROR alpha, ROR beta, and ROR gamma. By binding to the ROR response elements (ROREs) on target gene promoters, RORs regulate a wide variety of cellular processes, including autophagy, mitophagy, oxidative stress, and inflammation. The regulatory roles of RORs are observed in cardiac cells, hepatocytes, pulmonary epithelial cells, renal cells, immune cells, and cancer cells. A growing body of clinical and experimental evidence suggests that ROR expression levels are markedly reduced under different pathological and stress conditions, suggesting that RORs may play a critical role in the pathogenesis of a variety of disease states, including myocardial infarction, immune disorders, cancer, and metabolic syndrome. Reductions in RORs are also associated with inhibition of autophagy, increased reactive oxygen species (ROS), and increased cell death, underscoring the importance of RORs in the regulation of these processes. Herein, we highlight the relationship between RORs and homeostatic processes that influence cell viability. Understanding how these intricate processes are governed at the cellular level is of high scientific and clinical importance to develop new therapeutic strategies that modulate ROR expression and disease progression.
C1 [Nematisouldaragh, Darya; Kirshenbaum, Eryn; Uzonna, Michael; Kirshenbaum, Lorrie; Rabinovich-Nikitin, Inna] Univ Manitoba, Rady Coll Med, Max Rady Fac Hlth Sci, Dept Physiol & Pathophysiol, Winnipeg, MB R2H 2A6, Canada.
   [Nematisouldaragh, Darya; Kirshenbaum, Eryn; Uzonna, Michael; Kirshenbaum, Lorrie; Rabinovich-Nikitin, Inna] St Boniface Gen Hosp, Albrechtsen Res Ctr, Inst Cardiovasc Sci, Winnipeg, MB R2H 2A6, Canada.
   [Kirshenbaum, Lorrie] Univ Manitoba, Rady Coll Med, Max Rady Fac Hlth Sci, Dept Pharmacol & Therapeut, Winnipeg, MB R2H 2A6, Canada.
C3 University of Manitoba; University of Manitoba; Saint Boniface Hospital;
   Children's Hospital Research Institute of Manitoba; University of
   Manitoba
RP Rabinovich-Nikitin, I (corresponding author), Univ Manitoba, Rady Coll Med, Max Rady Fac Hlth Sci, Dept Physiol & Pathophysiol, Winnipeg, MB R2H 2A6, Canada.; Rabinovich-Nikitin, I (corresponding author), St Boniface Gen Hosp, Albrechtsen Res Ctr, Inst Cardiovasc Sci, Winnipeg, MB R2H 2A6, Canada.
EM dnemati@sbrc.ca; ekirshenbaum@sbrc.ca; muzonna@sbrc.ca;
   lkirshenbaum@sbrc.ca; irabinovich-nikitin@sbrc.ca
FU Canadian Institute of Health Research (CIHR); St. Boniface Hospital
   Research Foundation [481258 PJT 183630]; Canada Research Chair in
   Molecular Cardiology; Family Professorship in Cardiovascular Sciences;
   Institute of Cardiovascular Sciences/Bank of Montreal scholarship
FX This work was supported by a grant to L.A.K. from the Canadian Institute
   of Health Research (CIHR) and St. Boniface Hospital Research Foundation,
   # 481258 PJT 183630. L.A.K. holds a Canada Research Chair in Molecular
   Cardiology. I.R.N. holds the Evelyn Wyrzykowski Family Professorship in
   Cardiovascular Sciences. D.N is supported by the Institute of
   Cardiovascular Sciences/Bank of Montreal scholarship.
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NR 133
TC 2
Z9 2
U1 2
U2 2
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD NOV
PY 2024
VL 25
IS 21
AR 11340
DI 10.3390/ijms252111340
PG 22
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA L5R4I
UT WOS:001351287500001
PM 39518891
OA gold
DA 2025-06-11
ER

PT J
AU Akoumianakis, I
   Akawi, N
   Antoniades, C
AF Akoumianakis, Ioannis
   Akawi, Nadia
   Antoniades, Charalambos
TI Exploring the Crosstalk between Adipose Tissue and the Cardiovascular
   System
SO KOREAN CIRCULATION JOURNAL
LA English
DT Review
DE Adipose tissue; Obesity; Cardiovascular disease; Oxidative stress
ID ANGIOTENSIN-ALDOSTERONE SYSTEM; BODY-FAT DISTRIBUTION;
   INSULIN-RESISTANCE; INCREASED EXPRESSION; OXIDATIVE STRESS; OBESITY
   PARADOX; ENDOTHELIAL FUNCTION; METABOLIC SYNDROME; HEART-FAILURE;
   RISK-FACTOR
AB Obesity is a clinical entity critically involved in the development and progression of cardiovascular disease (CVD), which is characterised by variable expansion of adipose tissue (AT) mass across the body as well as by phenotypic alterations in AT. AT is able to secrete a diverse spectrum of biologically active substances called adipocytokines, which reach the cardiovascular system via both endocrine and paracrine routes, potentially regulating a variety of physiological and pathophysiological responses in the vasculature and heart. Such responses include regulation of inflammation and oxidative stress as well as cell proliferation, migration and hypertrophy. Furthermore, clinical observations such as the "obesity paradox," namely the fact that moderately obese patients with CVD have favourable clinical outcome, strongly indicate that the biological "quality" of AT may be far more crucial than its overall mass in the regulation of CVD pathogenesis. In this work, we describe the anatomical and biological diversity of AT in health and metabolic disease; we next explore its association with CVD and, importantly, novel evidence for its dynamic crosstalk with the cardiovascular system, which could regulate CVD pathogenesis.
C1 [Akoumianakis, Ioannis; Akawi, Nadia; Antoniades, Charalambos] Univ Oxford, Div Cardiovasc Med, Oxford, England.
C3 University of Oxford
RP Antoniades, C (corresponding author), Univ Oxford, Div Cardiovasc Med, John Radcliffe Hosp, CVM L6 West Wing,Headley Way, Oxford OX3 9DU, England.
EM antoniad@well.ox.ac.uk
RI Akawi, Nadia/AAX-2650-2020; Akoumianakis, Ioannis/ACD-9816-2022
OI Akawi, Nadia/0000-0001-6311-7028; Antoniades,
   Charalambos/0000-0002-6983-5423; Akoumianakis,
   Ioannis/0000-0002-4674-0210
FU British Heart Foundation [FS/16/15/32047, PG/13/56/30383]; National
   Institute for Health Research Oxford Biomedical Research Centre;
   European commission (Initial Training Network [ITN] network RADical
   reduction of OXidative stress in cardiovascular disease [RADOX]);
   NovoNordisk Foundation [NNF15CC0018486]; Alexandros S. Onassis Public
   Benefit Foundation
FX Charalambos Antoniades acknowledges support by the British Heart
   Foundation (FS/16/15/32047 and PG/13/56/30383), the National Institute
   for Health Research Oxford Biomedical Research Centre, the European
   commission (Initial Training Network [ITN] network RADical reduction of
   OXidative stress in cardiovascular disease [RADOX]) and the NovoNordisk
   Foundation (NNF15CC0018486). Ioannis Akoumianakis acknowledges support
   by the Alexandros S. Onassis Public Benefit Foundation.
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NR 110
TC 12
Z9 14
U1 0
U2 3
PU KOREAN SOC CARDIOLOGY
PI SEOUL
PA 101-1704, LOTTE CASTLE PRESIDENT, 109, MAPO-DAERO, MAPO-GU, SEOUL,
   04146, SOUTH KOREA
SN 1738-5520
EI 1738-5555
J9 KOREAN CIRC J
JI Korean Circ. J.
PD SEP
PY 2017
VL 47
IS 5
BP 670
EP 685
DI 10.4070/kcj.2017.0041
PG 16
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA FK9PB
UT WOS:000413842200005
PM 28955384
OA Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Eller, NH
   Netterstrom, B
   Allerup, P
AF Eller, NH
   Netterstrom, B
   Allerup, P
TI Progression in intima media thickness-the significance of hormonal
   biomarkers of chronic stress
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE atherosclerosis; intima media; thickness; progression; salivary cortisol
ID EARLY CAROTID ATHEROSCLEROSIS; RISK-FACTORS; 4-YEAR PROGRESSION;
   METABOLIC SYNDROME; WORKPLACE DEMANDS; CORTISOL RESPONSE; COMMUNITIES;
   POPULATION; ARTERY; ASSOCIATIONS
AB Objective: The pathophysiological pathways from stress caused by psychosocial stress to IHD has not been dealt with very extensively. The objective of this study was to analyse the association between cortisol levels and progression in intima media thickness (IMT).
   Methods and results: In 1998 and 2002, 95 participants went through a clinical investigation including ultrasound of the artery carotis communis. Progression in IMT was analysed in relation to levels of salivary cortisol in 1998 and the average levels of salivary cortisol in 1998/2002. Further, the significance of conventional coronary risk factors, testosterone and dehydro-epiandrosterone sulphate (DHEAS) were evaluated. Among the men, only age and HDL-cholesterol (negative) were significantly correlated with progression in IMT. Among the women, awakening cortisol response was significantly correlated with progression in IMT. Testosterone and DHEAS were borderline significantly associated (negatively) with progression in IMT in both genders.
   Conclusion: Progression in atherosclerosis were determined by different risk factors in women and men. The awakening cortisol response was of great importance to IMT progression in women but not in men. (c) 2005 Elsevier Ltd. All rights reserved.
C1 Hillerod Sygehus, Clin Occupat Med, DK-3400 Hillerod, Denmark.
   Cent Hosp Hillerod, Dept Clin Physiol, DK-3400 Hillerod, Denmark.
   Aarhus Univ, DK-2200 Copenhagen, Denmark.
C3 University of Copenhagen; Aarhus University
RP Hillerod Sygehus, Clin Occupat Med, Helsevej 2-4, DK-3400 Hillerod, Denmark.
EM nael@fa.dk
RI Allerup, Peter/JDN-1649-2023; Eller, Nanna/B-3981-2009
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NR 42
TC 52
Z9 57
U1 0
U2 5
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD SEP
PY 2005
VL 30
IS 8
BP 715
EP 723
DI 10.1016/j.psyneuen.2005.01.005
PG 9
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA 936GA
UT WOS:000229842300001
PM 15882934
DA 2025-06-11
ER

PT J
AU Pagano, E
   Souto, EB
   Durazzo, A
   Sharifi-Rad, J
   Lucarini, M
   Souto, SE
   Salehi, B
   Zam, W
   Montanaro, V
   Lucariello, G
   Izzo, AA
   Santini, A
   Romano, B
AF Pagano, Ester
   Souto, Eliana B.
   Durazzo, Alessandra
   Sharifi-Rad, Javad
   Lucarini, Massimo
   Souto, Selma E.
   Salehi, Bahare
   Zam, Wissam
   Montanaro, Vittorino
   Lucariello, Giuseppe
   Izzo, Angelo A.
   Santini, Antonello
   Romano, Barbara
TI Ginger (Zingiber officinale Roscoe) as a nutraceutical: Focus on
   the metabolic, analgesic, and antiinflammatory effects
SO PHYTOTHERAPY RESEARCH
LA English
DT Review
DE diabetes; dietary supplements; ginger; gingerols; hypercholesterolemia;
   inflammation; metabolic syndrome; nutraceuticals; Zingiber officinale
ID KAPPA-B ACTIVATION; DIETARY GINGER; PLASMA-CHOLESTEROL; ETHANOLIC
   EXTRACT; OXIDATIVE STRESS; ANTIOXIDANT; INHIBITION; 6-GINGEROL;
   SHOGAOLS; METAANALYSIS
AB Ginger (from the rizhome of Zingiber officinale Roscoe) has been widely used in ethnomedicine for the cure of several ailments. Main active ingredients include phenolic compounds named gingerols. In modern phytotherapy, ginger preparations are predominantly used to counteract nausea and vomiting in pregnant women. However, a number of other pharmacological actions of potential therapeutic interest, which might broaden the spectrum of its clinical use, have been reported. This focused review aims at giving a shot on the antinflammatory, analgesic, and metabolic actions of Zingiber officinale preparations, with a discussion on the clinical applications in knee osteoarthritis, dysmenorrhea, type-2 diabetes, hyperlipidemia, overweight, and obesity.
C1 [Pagano, Ester; Lucariello, Giuseppe; Izzo, Angelo A.; Santini, Antonello; Romano, Barbara] Univ Napoli Federico II, Sch Med, Dept Pharm, Naples, Italy.
   [Souto, Eliana B.] Univ Coimbra Azinhaga Santa Comba, Fac Pharm, Coimbra, Portugal.
   [Souto, Eliana B.] Univ Minho, CEB Ctr Biol Engn, Braga, Portugal.
   [Durazzo, Alessandra; Lucarini, Massimo] CREA Res Ctr Food & Nutr, Rome, Italy.
   [Sharifi-Rad, Javad] Shahid Beheshti Univ Med Sci, Phytochem Res Ctr, Tehran, Iran.
   [Souto, Selma E.] Hosp Sao Joao, Dept Endocrinol, Alameda Prof Hernani Monteiro, Porto, Portugal.
   [Salehi, Bahare] Bam Univ Med Sci, Sch Med, Student Res Comm, Bam, Iran.
   [Zam, Wissam] Al Andalus Univ Med Sci, Dept Analyt & Food Chem, Fac Pharm, Tartous, Syria.
   [Montanaro, Vittorino] Div Urol, PO Castellammare Stabia Napoli, Naples, Italy.
C3 University of Naples Federico II; Universidade de Coimbra; Universidade
   do Minho; Consiglio per la Ricerca in Agricoltura e L'analisi
   Dell'economia Agraria (CREA); Shahid Beheshti University Medical
   Sciences; Sao Joao Hospital
RP Sharifi-Rad, J (corresponding author), Shahid Beheshti Univ Med Sci, Phytochem Res Ctr, Tehran, Iran.; Santini, A; Romano, B (corresponding author), Univ Naples Federico II, Sch Med & Surg, Dept Pharm, Naples, Italy.
EM javad.sharifirad@gmail.com; asantini@unina.it; barbara.romano@unina.it
RI Izzo, Angelo/F-9612-2015; Souto, Eliana B./T-1645-2019; Souto,
   Selma/O-5539-2014; Montanaro, Vittorino/LFV-6245-2024; Santini,
   Antonello/J-4923-2019; Lucarini, Massimo/AAL-9254-2020; Durazzo,
   Alessandra/AAN-4182-2020; Sharifi-Rad, Javad/D-5747-2016
OI Souto, Selma B/0000-0002-6404-8818; Romano, Barbara/0000-0003-2772-5231;
   zam, wissam/0000-0002-2733-1884; Sharifi-Rad, Javad/0000-0002-7301-8151;
   Pagano, Ester/0000-0003-2872-1734; Izzo, Angelo/0000-0002-8557-2133;
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NR 100
TC 32
Z9 34
U1 9
U2 71
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0951-418X
EI 1099-1573
J9 PHYTOTHER RES
JI Phytother. Res.
PD MAY
PY 2021
VL 35
IS 5
BP 2403
EP 2417
DI 10.1002/ptr.6964
EA DEC 2020
PG 15
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA SG5QV
UT WOS:000595656700001
PM 33278054
DA 2025-06-11
ER

PT J
AU Itoh, M
   Ogawa, Y
   Suganami, T
AF Itoh, Michiko
   Ogawa, Yoshihiro
   Suganami, Takayoshi
TI Chronic inflammation as a molecular basis of nonalcoholic
   steatohepatitis: role of macrophages and fibroblasts in the liver
SO NAGOYA JOURNAL OF MEDICAL SCIENCE
LA English
DT Review
DE chronic inflammation; macrophages; fibroblasts
ID HEPATIC-FIBROSIS; METABOLIC SYNDROME; DISEASE; MODEL; MANAGEMENT; NAFLD;
   FEATURES; LEPTIN; STAGE
AB The pathological spectrum of nonalcoholic fatty liver disease includes simple steatosis and nonalcoholic steatohepatitis (NASH). the latter of which is the leading cause of cirrhosis and hepatocellular carcinoma. The available evidence shows that parenchymal cell injury and death trigger inflammation and tissue fibrosis. During the development of liver fibrosis, stromal cells dramatically changes in their cellular component and activation status responding to hepatocyte injury due to various etiologies. It is important to understand how cell death induces chronic inflammation and fibrosis. and the disease-specific macrophages and fibroblasts responsible for NASH development under metabolic stress. This review discusses recent progress in the understanding the pathogenesis of NASH, focusing on disease-specific macrophages and fibroblasts.
C1 [Itoh, Michiko; Ogawa, Yoshihiro; Suganami, Takayoshi] Nagoya Univ, Res Inst Environm Med, Dept Mol Med & Metab, Nagoya, Aichi, Japan.
   [Itoh, Michiko] Kanagawa Inst Ind Sci & Technol, Kawasaki, Kanagawa, Japan.
   [Ogawa, Yoshihiro] Kyushu Univ, Grad Sch Med Sci, Dept Med & Bioregulatory Sci, Fukuoka, Japan.
   [Suganami, Takayoshi] Nagoya Univ, Dept Inummometab, Grad Sch Med, Nagoya, Aichi, Japan.
C3 Nagoya University; Kanagawa Academy Science & Technology; Kyushu
   University; Nagoya University
RP Suganami, T (corresponding author), Nagoya Univ, Dept Mol Med & Metab, Res Inst Environm Med, Chikusa Ku, Furo Cho, Nagoya, Aichi 4648601, Japan.
EM suganami@riem.nagoya-u.ac.jp
RI SUGANAMI, Takayoshi/A-9475-2016; Itoh, Michiko/LDV-8630-2024
OI Suganami, Takayoshi/0000-0002-1918-0465; Ogawa,
   Yoshihiro/0000-0002-0834-2836
FU Ministry of Education, Culture, Sports, Science and Technology of Japan
   [16H05171, 16KT0110, 16K08732, 17H05500, 19K07475]; AMED-CREST
   [JP19gm1210009]; Takeda Science Foundation; Hori Sciences and Arts
   Foundation; Suzuken Memorial Foundation; Japan Diabetes Society; MSD
   Life Science Foundation; Terumo Life Science Foundation; Grants-in-Aid
   for Scientific Research [20H04944, 20H05503, 19K07475, 16H05171,
   16KT0110, 16K08732, 20H03447, 17H05500] Funding Source: KAKEN
FX This work was supported in part by Grants-in-Aid for Scientific Research
   from the Ministry of Education, Culture, Sports, Science and Technology
   of Japan (16H05171, 16KT0110, 16K08732, 17H05500, and 19K07475) and
   AMED-CREST (JP19gm1210009). This work was also supported by research
   grants from Takeda Science Foundation, The Hori Sciences and Arts
   Foundation, Suzuken Memorial Foundation, the Japan Diabetes Society, MSD
   Life Science Foundation and Terumo Life Science Foundation. We thank Dr.
   Joel K. Elmquist (University of Texas Southwestern Medical Center) for
   his generous gift of MC4R-KO mice.
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NR 39
TC 5
Z9 5
U1 0
U2 5
PU NAGOYA UNIV, SCH MED
PI NAGOYA
PA EDITORIAL OFF, NAGOYA UNIV MED LIB, SCH MED, 65 TSURUMAI-CHO SHOWA- KU,
   NAGOYA, 466-8550, JAPAN
SN 2186-3326
EI 0027-7622
J9 NAGOYA J MED SCI
JI Nagoya J. Med. Sci.
PD AUG
PY 2020
VL 82
IS 3
BP 391
EP 397
DI 10.18999/nagjms.82.3.391
PG 7
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA ND8DG
UT WOS:000562132200001
PM 33132423
DA 2025-06-11
ER

PT J
AU Kalupahana, NS
   Moustaid-Moussa, N
   Claycombe, KJ
AF Kalupahana, Nishan S.
   Moustaid-Moussa, Naima
   Claycombe, Kate J.
TI Immunity as a link between obesity and insulin resistance
SO MOLECULAR ASPECTS OF MEDICINE
LA English
DT Review
DE Obesity; Insulin resistance; Adipose tissue inflammation; Type-2
   diabetes
ID ADIPOSE-TISSUE INFLAMMATION; ENDOPLASMIC-RETICULUM STRESS;
   NECROSIS-FACTOR-ALPHA; DIET-INDUCED OBESITY; T-CELLS; MATRIX
   METALLOPROTEINASES; MACROPHAGE ACCUMULATION; SKELETAL-MUSCLE; ADIPOCYTE
   SIZE; IKK-BETA
AB Obesity is a major public health problem in the United States and worldwide. Further, obesity is causally linked to the pathogenesis of insulin resistance, metabolic syndrome and type-2 diabetes (T2D). A chronic low-grade inflammation occurring in adipose tissue is at least in part responsible for the obesity-induced insulin resistance. This adipose tissue inflammation is characterized by changes in immune cell populations giving rise to altered adipo/cytokine profiles, which in turn induces skeletal muscle and hepatic insulin resistance. Detailed molecular mechanisms of insulin resistance, adipose tissue inflammation and the implications of these findings on therapeutic strategies are discussed in this review. Published by Elsevier Ltd.
C1 [Claycombe, Kate J.] USDA ARS, Grand Forks Human Nutr Res Ctr, Grand Forks, ND 58203 USA.
   [Kalupahana, Nishan S.; Moustaid-Moussa, Naima] Univ Tennessee, Obes Res Ctr, Knoxville, TN 37996 USA.
   [Kalupahana, Nishan S.] Univ Peradeniya, Fac Med, Dept Physiol, Peradeniya, Sri Lanka.
   [Moustaid-Moussa, Naima] Univ Tennessee, Dept Anim Sci, Knoxville, TN 37996 USA.
   [Moustaid-Moussa, Naima] Univ Tennessee, UT Extens Dept Family & Consumer Sci, Knoxville, TN 37996 USA.
C3 United States Department of Agriculture (USDA); University of Tennessee
   System; University of Tennessee Knoxville; University of Peradeniya;
   University of Tennessee System; University of Tennessee Knoxville; UT
   Institute of Agriculture; University of Tennessee System; University of
   Tennessee Knoxville; UT Institute of Agriculture
RP Claycombe, KJ (corresponding author), USDA ARS, Grand Forks Human Nutr Res Ctr, 2420 2nd Ave N,Stop 9034, Grand Forks, ND 58203 USA.
EM kate.claycombe@ars.usda.gov
RI Kalupahana, Nishan/E-1913-2011; Moustaid-Moussa, Naima/B-9067-2014
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NR 91
TC 192
Z9 204
U1 3
U2 56
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0098-2997
EI 1872-9452
J9 MOL ASPECTS MED
JI Mol. Asp. Med.
PD FEB
PY 2012
VL 33
IS 1
SI SI
BP 26
EP 34
DI 10.1016/j.mam.2011.10.011
PG 9
WC Biochemistry & Molecular Biology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Research & Experimental Medicine
GA 896CJ
UT WOS:000300542700004
PM 22040698
DA 2025-06-11
ER

PT J
AU Li, XL
   Jiang, C
   Wang, QH
   Yang, SB
   Cao, YY
   Hao, JN
   Niu, DC
   Chen, Y
   Han, B
   Jia, X
   Zhang, P
   Li, YS
AF Li, Xianglong
   Jiang, Cong
   Wang, Qinghua
   Yang, Shaobo
   Cao, Yuanyuan
   Hao, Ji-Na
   Niu, Dechao
   Chen, Yan
   Han, Bo
   Jia, Xin
   Zhang, Peng
   Li, Yongsheng
TI A "Valve-Closing" Starvation Strategy for Amplification of
   Tumor-Specific Chemotherapy
SO ADVANCED SCIENCE
LA English
DT Article
DE differential stress sensitization; glucose metabolism; GLUT1 inhibition;
   stability-controllable nanomedicines; starvation-sensitized chemotherapy
ID CANCER; FAMILY; CELLS
AB Starvation-dependent differential stress sensitization effect between normal and tumor cells provides a potentially promising strategy to amplify chemotherapy effects and reduce side effects. However, the conventional starvation approaches such as glucose oxidase (Gox)-induced glucose depletion and nanomedicine-enabled vascular embolism usually suffer from aggravated tumor hypoxia, systemic toxicity, and unpredictable metabolic syndrome. Herein, a novel "valve-closing" starvation strategy is developed to amplify the chemotherapy effects via closing the "valve" of glucose transported into tumor cells, which is accomplished by a glucose transporters 1 (GLUT1, valve of glucose uptake) inhibitor (Genistein, Gen) and chemotherapeutic agent (Curcumin, Cur) coloaded hybrid organosilica-micelles nanomedicine (designated as (Gen + Cur)@FOS) with controllable stability. In vitro and in vivo results demonstrate that (Gen + Cur)@FOS can effectively reduce glucose/adenosine triphosphate levels in tumor cells by inhibiting GLUT1 expression (i.e., "valve-closing") to induce the starvation of tumor cells, thus weakening the resistance of tumor cells to apoptosis caused by chemotherapy, and consequently contributing to the remarkably improved antitumor efficiency and minimized side effects based on the stress sensitization effect mediated by GLUT1 inhibition-induced starvation. This "valve-closing" starvation strategy provides a promising paradigm for the development of novel nanotherapeutics with amplified chemotherapy effect.
C1 [Li, Xianglong; Wang, Qinghua; Yang, Shaobo; Cao, Yuanyuan; Hao, Ji-Na; Niu, Dechao; Li, Yongsheng] East China Univ Sci & Technol, Frontier Sci Ctr Mat Biol & Dynam Chem, Shanghai Engn Res Ctr Hierarch Nanomat,Key Lab Ul, Minist Educ,Sch Mat Sci & Engn,Lab Low Dimens Mat, Shanghai 200237, Peoples R China.
   [Jiang, Cong; Chen, Yan; Zhang, Peng] Tongji Univ, Sch Med, Shanghai Pulm Hosp, Dept Thorac Surg, Shanghai 200092, Peoples R China.
   [Han, Bo; Li, Yongsheng] Shihezi Univ, Sch Pharm, Minist Educ, Key Lab Xinjiang Endem Phytomed Resources, Shihezi 832003, Peoples R China.
   [Jia, Xin; Li, Yongsheng] Shihezi Univ, Key Lab Green Proc Chem Engn Xinjiang Bingtuan, Sch Chem & Chem Engn, Shihezi 832003, Peoples R China.
C3 Ministry of Education - China; East China University of Science &
   Technology; Tongji University; Ministry of Education - China; Shihezi
   University; Shihezi University
RP Hao, JN; Li, YS (corresponding author), East China Univ Sci & Technol, Frontier Sci Ctr Mat Biol & Dynam Chem, Shanghai Engn Res Ctr Hierarch Nanomat,Key Lab Ul, Minist Educ,Sch Mat Sci & Engn,Lab Low Dimens Mat, Shanghai 200237, Peoples R China.; Zhang, P (corresponding author), Tongji Univ, Sch Med, Shanghai Pulm Hosp, Dept Thorac Surg, Shanghai 200092, Peoples R China.; Li, YS (corresponding author), Shihezi Univ, Sch Pharm, Minist Educ, Key Lab Xinjiang Endem Phytomed Resources, Shihezi 832003, Peoples R China.; Li, YS (corresponding author), Shihezi Univ, Key Lab Green Proc Chem Engn Xinjiang Bingtuan, Sch Chem & Chem Engn, Shihezi 832003, Peoples R China.
EM jinahao@ecust.edu.cn; zhangpeng1121@tongji.edu.cn; ysli@ecust.edu.cn
RI li, xianglong/HTS-1090-2023; Zhang, Peng/KXQ-5251-2024; Wang,
   Qinghua/GVT-3252-2022; Jia, Xin/AAT-7734-2020; Xiaoming,
   Liu/H-9487-2013; cao, yuan/GRR-9461-2022
FU National Natural Science Foundation of China [51621002, 51972112,
   52172279, 21805087, 81972172]; Basic Research Program of Shanghai
   [21JC1406003, 19JC1411700]; Leading Talents in Shanghai in 2018, Program
   of Shanghai Academic/Technology Research Leader [19XD1423200]; Shanghai
   Rising Star Program [21QA1402200]; Natural Science Foundation of
   Shanghai [21ZR1416600]; 111 project [B14018]; Programs of Shanghai
   Pulmonary Hospital [FKCX1904]
FX X.L. and C.J. contributed equally to this work. This work was
   financially supported by the National Natural Science Foundation of
   China (Nos. 51621002, 51972112, 52172279, 21805087, and 81972172), Basic
   Research Program of Shanghai (21JC1406003 and 19JC1411700), Leading
   Talents in Shanghai in 2018, Program of Shanghai Academic/Technology
   Research Leader (19XD1423200), Shanghai Rising Star Program
   (21QA1402200), the Natural Science Foundation of Shanghai (21ZR1416600),
   the 111 project (B14018), and Programs of Shanghai Pulmonary Hospital
   (FKCX1904). Animal experiments were executed according to the protocol
   approved by the Laboratory Animal Management Committee of East China
   University of Science and Technology (approval number:
   ECUST-2020-04001).
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NR 38
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Z9 56
U1 9
U2 151
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
EI 2198-3844
J9 ADV SCI
JI Adv. Sci.
PD MAR
PY 2022
VL 9
IS 8
AR 2104671
DI 10.1002/advs.202104671
EA JAN 2022
PG 10
WC Chemistry, Multidisciplinary; Nanoscience & Nanotechnology; Materials
   Science, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Science & Technology - Other Topics; Materials Science
GA ZT0AK
UT WOS:000743188300001
PM 35038243
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Chukwurah, E
   Farabaugh, KT
   Guan, BJ
   Ramakrishnan, P
   Hatzoglou, M
AF Chukwurah, Evelyn
   Farabaugh, Kenneth T.
   Guan, Bo-Jhih
   Ramakrishnan, Parameswaran
   Hatzoglou, Maria
TI A tale of two proteins: PACT and PKR and their roles in inflammation
SO FEBS JOURNAL
LA English
DT Review
DE inflammasome; inflammation; metaflammation; PACT; PKR; RIG-I-like
   receptors
ID NF-KAPPA-B; RNA-BINDING-PROTEIN; TOLL-LIKE RECEPTORS; KINASE PKR; RIG-I;
   GENE-EXPRESSION; TAR RNA; CELLULAR ACTIVATOR; OXIDATIVE STRESS;
   ADIPOSE-TISSUE
AB Inflammation is a pathological hallmark associated with bacterial and viral infections, autoimmune diseases, genetic disorders, obesity and diabetes, as well as environmental stresses including physical and chemical trauma. Among numerous proteins regulating proinflammatory signaling, very few such as Protein kinase R (PKR), have been shown to play an all-pervading role in inflammation induced by varied stimuli. PKR was initially characterized as an interferon-inducible gene activated by viral double-stranded RNA with a role in protein translation inhibition. However, it has become increasingly clear that PKR is involved in multiple pathways that promote inflammation in response to stress activation, both dependent on and independent of its cellular protein activator of PKR (PACT). In this review, we discuss the signaling pathways that contribute to the initiation of inflammation, including Toll-like receptor, interferon, and RIG-I-like receptor signaling, as well as inflammasome activation. We go on to discuss the specific roles that PKR and PACT play in such proinflammatory signaling, as well as in metabolic syndrome- and environmental stress-induced inflammation.
C1 [Chukwurah, Evelyn; Guan, Bo-Jhih; Hatzoglou, Maria] Case Western Reserve Univ, Dept Genet & Genome Sci, Cleveland, OH 44106 USA.
   [Farabaugh, Kenneth T.] Case Western Reserve Univ, Dept Pharmacol, Cleveland, OH 44106 USA.
   [Ramakrishnan, Parameswaran] Case Western Reserve Univ, Dept Pathol, Cleveland, OH 44106 USA.
C3 University System of Ohio; Case Western Reserve University; University
   System of Ohio; Case Western Reserve University; University System of
   Ohio; Case Western Reserve University
RP Hatzoglou, M (corresponding author), Case Western Reserve Univ, Dept Genet & Genome Sci, Cleveland, OH 44106 USA.; Ramakrishnan, P (corresponding author), Case Western Reserve Univ, Dept Pathol, Cleveland, OH 44106 USA.
EM parameswaran.ramakrishnan@case.edu; maria.hatzoglou@case.edu
RI Ramakrishnan, Parameswaran/AAB-9083-2020
OI Chukwurah, Evelyn/0000-0002-9706-7003; Ramakrishnan,
   Parameswaran/0000-0002-1314-827X
FU NIH [R01DK53307, R01DK060596, R01DK113196]; CDDRCC pilot grant [NIH
   DK097948]; NIH/NIAID [R01AI116730, R21AI144264]; National Cancer
   Institute [R21CA246194] Funding Source: NIH RePORTER; National Institute
   of Diabetes and Digestive and Kidney Diseases [R01DK113196] Funding
   Source: NIH RePORTER
FX This body of work was supported by the following grants: NIH R01DK53307,
   R01DK060596, and R01DK113196 to MH, CDDRCC pilot grant NIH DK097948 to
   MH, NIH/NIAID grants R01AI116730 and R21AI144264 to PR; and CDDRCC pilot
   grant NIH DK097948 to PR.
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NR 242
TC 44
Z9 51
U1 4
U2 21
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-464X
EI 1742-4658
J9 FEBS J
JI FEBS J.
PD NOV
PY 2021
VL 288
IS 22
BP 6365
EP 6391
DI 10.1111/febs.15691
EA JAN 2021
PG 27
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA WX2JE
UT WOS:000607649000001
PM 33387379
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Tao, WJ
   Sun, WJ
   Liu, LJ
   Wang, G
   Xiao, ZP
   Pei, X
   Wang, MQ
AF Tao, Wenjing
   Sun, Wanjing
   Liu, Lujie
   Wang, Geng
   Xiao, Zhiping
   Pei, Xun
   Wang, Minqi
TI Chitosan Oligosaccharide Attenuates Nonalcoholic Fatty Liver Disease
   Induced by High Fat Diet through Reducing Lipid Accumulation,
   Inflammation and Oxidative Stress in C57BL/6 Mice
SO MARINE DRUGS
LA English
DT Article
DE chitosan oligosaccharide; nonalcoholic fatty liver disease; lipid
   accumulation; inflammation; oxidative stress; AMPK
ID BIOLOGICAL-ACTIVITIES; PPAR-ALPHA; STEATOHEPATITIS; MECHANISM; OBESITY;
   MACROPHAGES; HOMEOSTASIS; METABOLISM; ACTIVATION; MANAGEMENT
AB Nonalcoholic fatty liver disease (NAFLD) has become the most common chronic liver disease closely associated with metabolic syndrome, but there are no validated pharmacological therapies. The aim of this study was to investigate the effect of chitosan oligosaccharide (COS) on NAFLD. Mice were fed either a control diet or a high-fat diet (HFD) with or without COS (200 or 400 mg/kg body weight (BW)) by oral gavage for seven weeks. Administration with COS significantly lowered serum lipid levels in the HFD-fed mice. The hepatic lipid accumulation was significantly decreased by COS, which was attributed to decreased expressions of lipogenic genes and increased expressions of fatty beta-oxidation-related genes. Moreover, pro-inflammatory cytokines, neutrophils infiltration, and macrophage polarization were decreased by COS in the liver. Furthermore, COS ameliorated hepatic oxidative stress by activating the nuclear factor E2-related factor 2 (Nrf2) pathway and upregulating gene expressions of antioxidant enzymes. These beneficial effects were mediated by the activation of the adenosine monophosphate-activated protein kinase (AMPK) signaling pathway. Therefore, COS might be a potent dietary supplement to ameliorate NAFLD.
C1 [Tao, Wenjing; Sun, Wanjing; Liu, Lujie; Wang, Geng; Xiao, Zhiping; Pei, Xun; Wang, Minqi] Zhejiang Univ, Coll Anim Sci, Key Lab Mol Anim Nutr, Minist Educ, Hangzhou 310058, Zhejiang, Peoples R China.
C3 Ministry of Education - China; Zhejiang University
RP Wang, MQ (corresponding author), Zhejiang Univ, Coll Anim Sci, Key Lab Mol Anim Nutr, Minist Educ, Hangzhou 310058, Zhejiang, Peoples R China.
EM taowenjing1127@163.com; sunwanjing@zju.edu.cn; liulj@zju.edu.cn;
   wanggeng@zju.edu.cn; xiaozp@zju.edu.cn; pxpeixun@zju.edu.cn;
   wangmq@zju.edu.cn
RI Lujie, Liu/K-1679-2019; Tao, Wenjing/GZK-7535-2022; wang,
   minqi/GVU-2388-2022
OI Tao, Wenjing/0000-0002-2622-3486; Xiao, Zhiping/0000-0003-0308-4759
FU Three Agricultural and Six-Party Research Cooperation Project of
   Zhejiang Province, China [CTZB-F180706LWZ-SNY1]; Science and Technology
   Key Projects of Zhejiang Province, China [2015C02022]
FX This work was financially supported by the Three Agricultural and
   Six-Party Research Cooperation Project of Zhejiang Province, China
   (grant number: CTZB-F180706LWZ-SNY1) and the Science and Technology Key
   Projects of Zhejiang Province, China (grant number: 2015C02022).
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NR 48
TC 67
Z9 71
U1 1
U2 47
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1660-3397
J9 MAR DRUGS
JI Mar. Drugs
PD NOV
PY 2019
VL 17
IS 11
AR 645
DI 10.3390/md17110645
PG 15
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA JV3JJ
UT WOS:000502262200043
PM 31744059
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Cherkas, A
   Golota, S
   Guéraud, F
   Abrahamovych, O
   Pichler, C
   Nersesyan, A
   Krupak, V
   Bugiichyk, V
   Yatskevych, O
   Pliatsko, M
   Eckl, P
   Knasmüller, S
AF Cherkas, Andriy
   Golota, Sergii
   Gueraud, Francoise
   Abrahamovych, Orest
   Pichler, Christoph
   Nersesyan, Armen
   Krupak, Volodymyr
   Bugiichyk, Vira
   Yatskevych, Ostap
   Pliatsko, Mykhaylo
   Eckl, Peter
   Knasmueller, Siegfried
TI A Helicobacter pylori-associated insulin resistance in
   asymptomatic sedentary young men does not correlate with inflammatory
   markers and urine levels of 8-iso-PGF2-α or
   1,4-dihydroxynonane mercapturic acid
SO ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
LA English
DT Article
DE Helicobacter pylori; sedentary lifestyle; insulin resistance; oxidative
   stress; inflammation
ID HEART-RATE-VARIABILITY; METABOLIC SYNDROME; PEPTIC-ULCER; EXTRAGASTRIC
   DISEASES; OXIDATIVE STRESS; GASTRIC-MUCOSA; INFECTION; ERADICATION;
   ASSAY
AB A potential contribution of H. pylori contamination to low-grade inflammation, oxidative stress (OS) and insulin resistance as well as correlations between these parameters in asymptomatic sedentary males was analysed. We enrolled 30 apparently healthy asymptomatic young subjects (18 H. pylori negative and 12 positive) and measured whole blood glucose, glycated haemoglobin, insulin, C-peptide, cortisol, aldosterone, testosterone, thyroid stimulating hormone, C-reactive protein, interleukins 6 and 10, TNF-alpha and comet assay. As markers of OS, we used urine levels of iso-PGF(2)-alpha and 1,4-dihydroxynonane mercapturic acid (DHN-MA). Twofold elevation of fasting insulin level and HOMA index in H. pylori-positive subjects (p<.05) was shown. Inflammatory parameters and monocyte DNA damage, urine levels of DHN-MA and iso-PGF2-alpha did not show significant differences between the groups. The early stage of H. pylori-triggered metabolic derangements in sedentary subjects include development of insulin resistance in H. pylori-positive subjects; however, there is no evidence of systemic inflammatory and OS-related changes.
C1 [Cherkas, Andriy; Abrahamovych, Orest; Bugiichyk, Vira; Yatskevych, Ostap; Pliatsko, Mykhaylo] Danylo Halytskyi Lviv Natl Med Univ, Dept Internal Med 1, Lvov, Ukraine.
   [Cherkas, Andriy] Lviv Coll Phys Culture, Dept Med, Lvov, Ukraine.
   [Golota, Sergii] Danylo Halytskyi Lviv Natl Med Univ, Dept Pharmaceut Organ & Bioorgan Chem, Lvov, Ukraine.
   [Gueraud, Francoise] Toulouse Univ, INRA, Res Ctr Food Toxicol Toxalim UMR1331, Team Prevent Promot Carcinogenesis Food 9, Toulouse, France.
   [Pichler, Christoph; Nersesyan, Armen; Knasmueller, Siegfried] Med Univ Vienna, Inst Canc Res, Dept Internal Med 1, Vienna, Austria.
   [Krupak, Volodymyr] Natl Acad Sci Ukraine, Inst Cell Biol, Lvov, Ukraine.
   [Bugiichyk, Vira] Lviv Reg Phtysiopulmonol Ctr, Lvov, Ukraine.
   [Eckl, Peter] Salzburg Univ, Dept Cell Biol & Physiol, Salzburg, Austria.
   [Golota, Sergii] Lviv Med Inst, Dept Pharmaceut Chem Pharmacol & Bot, Lvov, Ukraine.
C3 Danylo Halytsky Lviv National Medical University; Ministry of Education
   & Science of Ukraine; Ivan Boberskyi Lviv State University of Physical
   Culture; Danylo Halytsky Lviv National Medical University; Universite
   Federale Toulouse Midi-Pyrenees (ComUE); INRAE; Universite de Toulouse;
   Universite Toulouse III - Paul Sabatier; Medical University of Vienna;
   National Academy of Sciences Ukraine; Institute of Cell Biology of NASU;
   Salzburg University; Danylo Halytsky Lviv National Medical University
RP Cherkas, A (corresponding author), Pekarska St 69, UA-79010 Lvov, Ukraine.
EM cherkasandriy@yahoo.com
RI Gueraud, Francoise/ITT-5567-2023; Abragamovic, Orest/M-9818-2019;
   Holota, Serhii/E-8502-2015; Cherkas, Andriy/H-8190-2018; Ackevic,
   Ostap/AAQ-3386-2021; Knasmuller, Siegfried/P-4347-2014
OI Pliatsko, Mykhailo/0000-0001-7083-6725; Gueraud,
   Francoise/0000-0001-5455-1244; Nersesyan, Armen/0000-0001-5571-7904;
   Abragamovic, Orest/0000-0001-6862-6809; Eckl, Peter/0000-0002-3842-1746;
   Holota, Serhii/0000-0002-9892-437X; Cherkas, Andriy/0000-0002-6652-6983;
   Ackevic, Ostap/0000-0001-5146-2553; Knasmuller,
   Siegfried/0000-0002-1638-4438
FU State Agency of Science, Innovations and Informatisation of Ukraine
   [M512-2011, M473-2012]; COST Actions [CM1001, CA16112]; OEAD Project [UA
   03/2011]; Alexander von Humboldt Foundation (Bonn, Germany)
FX The work was supported by the State Agency of Science, Innovations and
   Informatisation of Ukraine contracts #M512-2011, #M473-2012, OEAD
   Project UA 03/2011, and by COST Actions B35 "LPO - Lipid Peroxidation
   associated Disorders," CM1001 "Chemistry of non-enzymatic protein
   modification - modulation of protein structure and function" and CA16112
   "Personalised Nutrition in aging society: redox control of major
   age-related diseases", A.C. was supported by the Georg Forster (HERMES)
   Scholarship from Alexander von Humboldt Foundation (Bonn, Germany).
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NR 48
TC 5
Z9 8
U1 0
U2 4
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1381-3455
EI 1744-4160
J9 ARCH PHYSIOL BIOCHEM
JI Arch. Physiol. Biochem.
PY 2018
VL 124
IS 3
BP 275
EP 285
DI 10.1080/13813455.2017.1396346
PG 11
WC Biochemistry & Molecular Biology; Biophysics; Endocrinology &
   Metabolism; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Endocrinology &
   Metabolism; Physiology
GA GM6NO
UT WOS:000438286700010
DA 2025-06-11
ER

PT J
AU Nigro, C
   Leone, A
   Raciti, GA
   Longo, M
   Mirra, P
   Formisano, P
   Beguinot, F
   Miele, C
AF Nigro, Cecilia
   Leone, Alessia
   Raciti, Gregory Alexander
   Longo, Michele
   Mirra, Paola
   Formisano, Pietro
   Beguinot, Francesco
   Miele, Claudia
TI Methylglyoxal-Glyoxalase 1 Balance: The Root of Vascular Damage
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE methylglyoxal; glyoxalase; vascular function; insulin-resistance
ID GLYCATION END-PRODUCTS; MICROVASCULAR ENDOTHELIAL-CELLS;
   ENDOPLASMIC-RETICULUM STRESS; INSULIN-RECEPTOR SUBSTRATE-1;
   NITRIC-OXIDE; DICARBONYL STRESS; DIABETIC-NEPHROPATHY; OXIDATIVE STRESS;
   COPY NUMBER; METABOLIC SYNDROME
AB The highly reactive dicarbonyl methylglyoxal (MGO) is mainly formed as byproduct of glycolysis. Therefore, high blood glucose levels determine increased MGO accumulation. Nonetheless, MGO levels are also increased as consequence of the ineffective action of its main detoxification pathway, the glyoxalase system, of which glyoxalase 1 (Glo1) is the rate-limiting enzyme. Indeed, a physiological decrease of Glo1 transcription and activity occurs not only in chronic hyperglycaemia but also with ageing, during which MGO accumulation occurs. MGO and its advanced glycated end products (AGEs) are associated with age-related diseases including diabetes, vascular dysfunction and neurodegeneration. Endothelial dysfunction is the first step in the initiation, progression and clinical outcome of vascular complications, such as retinopathy, nephropathy, impaired wound healing and macroangiopathy. Because of these considerations, studies have been centered on understanding the molecular basis of endothelial dysfunction in diabetes, unveiling a central role of MGO-Glo1 imbalance in the onset of vascular complications. This review focuses on the current understanding of MGO accumulation and Glo1 activity in diabetes, and their contribution on the impairment of endothelial function leading to diabetes-associated vascular damage.
C1 [Nigro, Cecilia; Leone, Alessia; Raciti, Gregory Alexander; Longo, Michele; Mirra, Paola; Formisano, Pietro; Beguinot, Francesco; Miele, Claudia] CNR, Res Unit URT, Inst Expt Endocrinol & Oncol G Salvatore, I-80131 Naples, Italy.
   [Nigro, Cecilia; Leone, Alessia; Raciti, Gregory Alexander; Longo, Michele; Mirra, Paola; Formisano, Pietro; Beguinot, Francesco; Miele, Claudia] Univ Naples Federico II, Dept Translat Med Sci, I-80131 Naples, Italy.
C3 Consiglio Nazionale delle Ricerche (CNR); University of Naples Federico
   II
RP Miele, C (corresponding author), CNR, Res Unit URT, Inst Expt Endocrinol & Oncol G Salvatore, I-80131 Naples, Italy.; Miele, C (corresponding author), Univ Naples Federico II, Dept Translat Med Sci, I-80131 Naples, Italy.
EM cecilia.nigro@alice.it; aleleone86@libero.it; gregoryraciti@gmail.com;
   mi_longo@libero.it; paolamirra.lib@libero.it; fpietro@unina.it;
   beguino@unina.it; c.miele@ieos.cnr.it
RI Formisano, Pietro/J-4237-2018; Longo, Michele/AAB-5972-2020; Nigro,
   Cecilia/K-7338-2016; LONGO, Michele/AAB-9188-2019
OI Leone, Alessia/0000-0002-0193-6826; NIGRO, Cecilia/0000-0001-8924-9731;
   LONGO, Michele/0000-0003-4798-0504; Formisano,
   Pietro/0000-0001-7020-6870; RACITI, GREGORYALEXANDER/0000-0003-2742-5634
FU European Foundation for the Studies of Diabetes (EFSD)/Novo Nordisk;
   Ministero dell'Universita e della Ricerca Scientifica (grants PRIN)
FX This work was supported by the European Foundation for the Studies of
   Diabetes (EFSD)/Novo Nordisk (2015-2017), by the Ministero
   dell'Universita e della Ricerca Scientifica (grants PRIN).
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NR 112
TC 90
Z9 93
U1 3
U2 17
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD JAN
PY 2017
VL 18
IS 1
AR 188
DI 10.3390/ijms18010188
PG 14
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA EJ2HL
UT WOS:000393030600185
PM 28106778
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Nguyen, LT
   Chen, H
   Pollock, CA
   Saad, S
AF Nguyen, Long T.
   Chen, Hui
   Pollock, Carol A.
   Saad, Sonia
TI Sirtuins-mediators of maternal obesity-induced complications in
   offspring?
SO FASEB JOURNAL
LA English
DT Review
DE fetal programming; metabolism; chronic diseases
ID HIGH-FAT DIET; PROMOTES CELL-SURVIVAL; ENDOPLASMIC-RETICULUM STRESS;
   BODY-MASS INDEX; OXIDATIVE STRESS; METABOLIC SYNDROME; GENE-EXPRESSION;
   REGULATES SIRT1; MITOCHONDRIAL DYSFUNCTION; SUPEROXIDE-DISMUTASE
AB Obesity is a complex metabolic disease, attributed to diverse and interactive genetic and environmental factors. The associated health consequences of obesity are pleiotropic, with individuals being more susceptible to chronic diseases such as type 2 diabetes mellitus, hypertension, and lipotoxicity-related chronic diseases. The contribution of maternal obesity to the offspring's predisposition to both obesity and its complications is increasingly recognized. Understanding the mechanisms underlying these "transmissible" effects is critical to develop therapeutic interventions to reduce the risk for "programmed" obesity. Sirtuins (SIRTs), particularly SIRT1 and SIRT3, are NAD+-dependent deacetylases that regulate metabolic balance and stress responses in both central and peripheral tissues, of which dysregulation is a well-established mediator for the development and effects of obesity. Nevertheless, their implication in the transmissible effects of maternal obesity across generations remains largely elusive. In this review, we examine multiple pathways and systems that are likely to mediate such effects, with particular emphasis on the role of SIRTs.-Nguyen, L. T., Chen, H., Pollock, C. A., Saad, S. Sirtuins-mediators of maternal obesity-induced complications in offspring? oFASEB J. 30, 1383-1390 (2016). www. asebj.org
C1 [Nguyen, Long T.; Pollock, Carol A.; Saad, Sonia] Univ Sydney, Royal N Shore Hosp, Kolling Inst, Sydney, NSW 2006, Australia.
   [Chen, Hui] Univ Technol Sydney, Fac Sci, Sch Life Sci, Sydney, NSW 2007, Australia.
C3 Royal North Shore Hospital; University of Sydney; Kolling Institute of
   Medical Research; University of Technology Sydney
RP Nguyen, LT (corresponding author), Royal N Shore Hosp, Kolling Inst, Level 9, St Leonards, NSW 2065, Australia.
EM lngu8923@uni.sydney.edu.au
RI Saad, Sonia/D-2914-2015; Pollock, Carol/H-1117-2015; Nguyen,
   Long/AAH-2433-2021; Chen, Hui/D-2005-2014
OI Nguyen, Long/0000-0002-0630-4959; Chen, Hui/0000-0001-6883-3752; Saad,
   Sonia/0000-0001-8067-8046
FU University of Sydney; Amgen Research Scholarship
FX L.T.N. was supported by an Early Career Research Ph.D. Scholarship from
   the University of Sydney, and an Amgen Research Scholarship.
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NR 98
TC 16
Z9 16
U1 0
U2 14
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
EI 1530-6860
J9 FASEB J
JI Faseb J.
PD APR
PY 2016
VL 30
IS 4
BP 1383
EP 1390
DI 10.1096/fj.15-280743
PG 8
WC Biochemistry & Molecular Biology; Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA DH2PR
UT WOS:000372629100002
PM 26667041
DA 2025-06-11
ER

PT J
AU Lee, KU
   Lee, IK
   Han, J
   Song, DK
   Kim, YM
   Song, HS
   Kim, HS
   Lee, WJ
   Koh, EH
   Song, KH
   Han, SM
   Kim, MS
   Park, IS
   Park, JY
AF Lee, KU
   Lee, IK
   Han, J
   Song, DK
   Kim, YM
   Song, HS
   Kim, HS
   Lee, WJ
   Koh, EH
   Song, KH
   Han, SM
   Kim, MS
   Park, IS
   Park, JY
TI Effects of recombinant adenovirus-mediated uncoupling protein 2
   overexpression on endothelial function and apoptosis
SO CIRCULATION RESEARCH
LA English
DT Article
DE endothelial cells; uncoupling protein; oxidative stress; vascular
   endothelial function; apoptosis
ID LOW-DENSITY-LIPOPROTEIN; FREE FATTY-ACID; OXIDATIVE STRESS;
   GENE-EXPRESSION; KINASE-C; GLUCOSE; DYSFUNCTION; INSULIN; MECHANISMS;
   DEATH
AB Increased oxidative stress in vascular cells plays a key role in the development of endothelial dysfunction and atherosclerosis. Uncoupling protein 2 (UCP2) is an important regulator of intracellular reactive oxygen species (ROS) production. This study was undertaken to test the hypothesis that, UCP2 functions as an inhibitor of the atherosclerotic process in endothelial cells. Adenovirus-mediated UCP2 (Ad-UCP2) overexpression led to a significant increase in endothelial nitric oxide synthase ( eNOS) and decrease in endothelin-1 mRNA expression in human aortic endothelial cells (HAECs). Moreover, UCP2 inhibited the increase in ROS production and NF-kappa B activation, and apoptosis of HAECs induced by lysophophatidylcholine (LPC) and linoleic acid. LPC and linoleic acid caused mitochondrial calcium accumulation and transient mitochondrial membrane hyperpolarization, which was followed by depolarization. UCP2 overexpression prevented these processes. In isolated rat aorta, Ad-UCP2 infection markedly improved impaired vascular relaxation induced by LPC. The data collectively suggest that UCP2, functions as a physiologic regulator of ROS generation in endothelial cells. Thus, measures to increase UCP2 expression in vascular endothelial cells may aid in preventing the development and progression of atherosclerosis in patients with metabolic syndrome.
C1 Univ Ulsan, Coll Med, Asan Med Ctr, Dept Internal Med, Seoul 138600, South Korea.
   Keimyung Univ, Coll Med, Taegu, South Korea.
   Kyungpook Natl Univ, Sch Med, Taegu, South Korea.
   Inje Univ, Coll Med, Pusan, South Korea.
   Inha Univ, Coll Med, Inchon, South Korea.
   Asan Inst Life Sci, Seoul, South Korea.
C3 University of Ulsan; Asan Medical Center; Keimyung University; Kyungpook
   National University (KNU); Inje University; Inha University
RP Univ Ulsan, Coll Med, Asan Med Ctr, Dept Internal Med, Song Pa POB 145, Seoul 138600, South Korea.
EM jypark@amc.seoul.kr
RI Lee, In-Kyu/AAR-6374-2021; LEE, WOO/E-3689-2010
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NR 45
TC 126
Z9 144
U1 0
U2 7
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0009-7330
EI 1524-4571
J9 CIRC RES
JI Circ.Res.
PD JUN 10
PY 2005
VL 96
IS 11
BP 1200
EP 1207
DI 10.1161/01.RES.0000170075.73039.5b
PG 8
WC Cardiac & Cardiovascular Systems; Hematology; Peripheral Vascular
   Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Hematology
GA 934AX
UT WOS:000229680000011
PM 15905464
OA Green Published
DA 2025-06-11
ER

PT J
AU Wang, YH
   Chen, YJ
   Ma, XF
   Guan, JL
   Gao, Y
   Hong, XZ
   Fu, P
   Zhou, FF
AF Wang, Yuhan
   Chen, Yijie
   Ma, Xiaofang
   Guan, Jili
   Gao, Yang
   Hong, Xuezi
   Fu, Ping
   Zhou, Feifei
TI Apo E protein and related markers show the prognosis of stress urinary
   incontinence rats treated with modified Buzhong Yiqi Decoction
SO INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
LA English
DT Article
DE Macromolecular protein; ApoE; Related markers; Buzhong Yiqi decoction;
   Stress incontinence rats; Prognostic influence
ID METABOLIC SYNDROME; LIPID-METABOLISM; SPHINGOMYELIN; ASSOCIATION
AB Stress urinary incontinence (SUI) is a common disease that seriously affects the quality of life of patients. In recent years, studies have shown that apolipoprotein E (ApoE) plays a role in neuroprotection and repair, but its specific role in SUI remains unclear. The aim of this study was to investigate the effect of macromolecular protein ApoE related markers on the prognosis of rats with SUI treated by modified Buzhong Yiqi Decoction (MBZYQD), in order to provide a new target for the treatment of SUI. Healthy rats were selected to establish a SUI model and divided into groups. The levels of ApoE related metabolites in blood of rats were detected by Metabolomics analysis and Lipidomics analysis. The urine leakage point pressure (LPP) were compared in each group, and the therapeutic effect of MBZYQD was evaluated. Compared with the model group, the LPP of rats in MBZYQD supplemented group was significantly higher. Compared with the control group, the LPP of MBZYQD was not statistically significant before and after treatment. The macromolecular protein ApoE may plays a key role in the treatment of SUI by MBZYQD, which can improve symptoms by regulating lipid metabolism repair.
C1 [Wang, Yuhan; Fu, Ping] Zhejiang Chinese Med Univ, Hangzhou Hosp Tradit Chinese Med, Hangzhou TCM Hosp, Hangzhou, Peoples R China.
   [Chen, Yijie; Ma, Xiaofang; Guan, Jili; Gao, Yang; Zhou, Feifei] Hangzhou Med Coll, Zhejiang Prov Peoples Hosp, Affiliated Peoples Hosp, Dept Reprod Endocrinol,Ctr Reprod Med, Hangzhou 310000, Peoples R China.
   [Hong, Xuezi] Hangzhou Normal Univ, Sch Clin Med, Hangzhou, Peoples R China.
   [Zhou, Feifei] 158 Shangtang Rd, Hangzhou 310000, Zhejiang, Peoples R China.
C3 Zhejiang Chinese Medical University; Hangzhou Medical College; Zhejiang
   Provincial People's Hospital; Hangzhou Normal University
RP Zhou, FF (corresponding author), Hangzhou Med Coll, Zhejiang Prov Peoples Hosp, Affiliated Peoples Hosp, Dept Reprod Endocrinol,Ctr Reprod Med, Hangzhou 310000, Peoples R China.
EM 5510025@zju.edu.cn
FU Department of Science and Tech-nology of State Administration of
   Traditional Chinese Medicine-Zhejiang Province Joint Construction
   Project [GZY-ZJ-KJ-24010]; Ministry of Education University-Industry
   Collaborative Education Program [2022, 220400576290837]
FX The work was supported by the Department of Science and Tech-nology of
   State Administration of Traditional Chinese Medicine-Zhejiang Province
   Joint Construction Project (No. GZY-ZJ-KJ-24010) and Ministry of
   Education University-Industry Collaborative Education Program 2022
   (No.220400576290837) .
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NR 39
TC 0
Z9 0
U1 2
U2 3
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0141-8130
EI 1879-0003
J9 INT J BIOL MACROMOL
JI Int. J. Biol. Macromol.
PD NOV
PY 2024
VL 280
AR 135996
DI 10.1016/j.ijbiomac.2024.135996
EA OCT 2024
PN 4
PG 11
WC Biochemistry & Molecular Biology; Chemistry, Applied; Polymer Science
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry; Polymer Science
GA I6D1P
UT WOS:001331135300001
PM 39326601
DA 2025-06-11
ER

PT J
AU Petrarca, C
   Andrisani, G
   Coppeta, L
   Mangifesta, R
AF Petrarca, C.
   Andrisani, G.
   Coppeta, L.
   Mangifesta, R.
TI Increased burnout risk in health workers in the covid-19 era
SO JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
LA English
DT Article
DE job related stress; job strain; occupational well-being; coping NK cell;
   cortisol
ID JOB STRAIN; MUSCULOSKELETAL PAIN; HOSPITAL WORKERS; CARE WORKERS;
   FOLLOW-UP; STRESS; IMPACT; SATISFACTION; METAANALYSIS; POPULATION
AB Emotional exhaustion, depersonalization and reduced personal fulfillment with loss of interest in work characterizes Burnout Syndrome (BS) in workers exposed to stress in the workplace. The COVID-19 pandemic is having a strong negative impact on the psycho-physical health of health workers thus favouring the appearance of BS. In addition, the fear of contagion and the close emotional relationship with seriously ill patients are the most important factors among those already known in the health environment in inducing and exacerbating the psychological effects of BS. Sleep disorders are deeply related with work overload due to prolonged work shifts, especially night ones. Moreover, the excessive workload in a condition of poor ergonomics, due to the use of personal protective equipment (PPEs), further increases the appearance of BS-associated health conditions such as the cardiovascular risk (CVR), metabolic syndrome and altered pain perception of musculoskeletal origin in particular. BS influences the hormone circadian rhythm with immune impact, mainly in reduction of NK cell activity. Psychological and social support for health workers should be carefully planned, otherwise the cost in terms of human resources, due to BS consequences, will be critical for the health system.
C1 [Petrarca, C.] Univ G dAnnunzio, Dept Med & Sci Ageing, Chieti, Italy.
   [Petrarca, C.; Mangifesta, R.] Univ G dAnnunzio, CAST, Chieti, Italy.
   [Andrisani, G.] Univ G dAnnunzio, Specialty Sch Occupat Med, Dept Med Oral & Biotechnol Sci, Chieti, Italy.
   [Coppeta, L.] Tor Vergata Hosp, Occupat Med Unit, Rome, Italy.
C3 G d'Annunzio University of Chieti-Pescara; G d'Annunzio University of
   Chieti-Pescara; G d'Annunzio University of Chieti-Pescara; University of
   Rome Tor Vergata; Policlin Tor Vergata
RP Andrisani, G (corresponding author), G dAnnunzio Univ Chieti Pescara, Unit Occupat Med, Via Vestini 31, I-66100 Chieti, Italy.
EM medicinadellavoro@unich.it
RI COPPETA, LUCA/B-5787-2013
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NR 87
TC 0
Z9 0
U1 0
U2 9
PU BIOLIFE SAS
PI SILVA MARINA (TE)
PA VIA S STEFANO 39 BIS, 64029 SILVA MARINA (TE), ITALY
SN 0393-974X
EI 1724-6083
J9 J BIOL REG HOMEOS AG
JI J. Biol. Regul. Homeost. Agents
PD MAY-JUN
PY 2021
VL 35
IS 3
SU 2
BP 21
EP 29
PG 9
WC Endocrinology & Metabolism; Immunology; Medicine, Research &
   Experimental; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Immunology; Research & Experimental
   Medicine; Physiology
GA YD3WW
UT WOS:000740347600004
DA 2025-06-11
ER

PT J
AU Lee, HJ
   Kwon, O
   Kim, JY
AF Lee, Hyo Jin
   Kwon, Oran
   Kim, Ji Yeon
TI Supplementation of a polyphenol extract from Ecklonia cava
   reduces body fat, oxidative and inflammatory stress in overweight
   healthy subjects with abdominal obesity: A randomized,
   placebo-controlled, double-blind trial
SO JOURNAL OF FUNCTIONAL FOODS
LA English
DT Article
DE Ecklonia cava extract; Inflammatory stress; Obesity; Oxidative stress;
   Polyphenol
ID INDUCED DIABETIC MICE; BROWN ALGA; CARDIOVASCULAR-DISEASE;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; AMPK ACTIVATION; ADIPOSE-TISSUE;
   RISK-FACTORS; IN-VITRO; DIECKOL
AB A randomized, placebo-controlled, double-blind trial was conducted using subjects with a body mass index over 25 kg/m(2) and under 30 kg/m(2). Eighty subjects were randomly assigned to receive either a placebo or Ecklonia cava extract (Seapolynol, 360 mg/day) for 12 weeks. In response to Seapolynol consumption, the body fat was significantly reduced from the baseline value. In the abdominal obesity subgroup, Seapolynol group presented with a significant decrease in total adipose tissue area, percent body fat and fat/lean mass ratio and an increase in skeletal muscle index. The oxidized low-density lipoprotein levels and endogenous antioxidant enzyme activities were significantly affected by Seapolynol supplementation. In addition, Seapolynol supplementation significantly increased the mRNA expression of lipid oxidation-related genes and decreased the expression of lipid synthesis-related genes. Inflammatory markers were also reduced by Seapolynol supplementation. In conclusion, Seapolynol may exert beneficial effects on obesity and related metabolic disorders in overweight and obese individuals.
C1 [Lee, Hyo Jin; Kwon, Oran] Ewha Womans Univ, Dept Nutr Sci & Food Management, Seoul 03760, South Korea.
   [Kim, Ji Yeon] Seoul Natl Univ Sci & Technol, Dept Food Sci & Technol, Seoul 01811, South Korea.
C3 Ewha Womans University; Seoul National University of Science &
   Technology
RP Kwon, O (corresponding author), Ewha Womans Univ, Dept Nutr Sci & Food Management, Seoul 03760, South Korea.; Kim, JY (corresponding author), Seoul Natl Univ Sci & Technol, Dept Food Sci & Technol, Seoul 01811, South Korea.
EM orank@ewha.ac.kr; jiyeonk@seoultech.ac.kr
RI Kim, Joo/X-7562-2019
OI Kwon, Oran/0000-0002-2031-7238; Kim, Ji Yeon/0000-0002-4316-2726
FU Bio-synergy Research Project - Ministry of Science, ICT, and Future
   Planning through the National Research Foundation [NRF2012M3A9C4048761]
FX The authors are grateful to the participants in this study. This work
   was supported by the Bio-synergy Research Project (NRF2012M3A9C4048761),
   funded by the Ministry of Science, ICT, and Future Planning through the
   National Research Foundation.
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NR 36
TC 11
Z9 11
U1 0
U2 10
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1756-4646
J9 J FUNCT FOODS
JI J. Funct. Food.
PD JUL
PY 2018
VL 46
BP 356
EP 364
DI 10.1016/j.jff.2018.04.062
PG 9
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA GS4PG
UT WOS:000443630000039
DA 2025-06-11
ER

PT J
AU Reynolds, RY
AF Reynolds, Raquel Yvonne
TI Prevalence and characteristics of prediabetes in workers in industry
SO JOURNAL OF ADVANCED NURSING
LA English
DT Article
DE nurse; occupational health nursing; prediabetes; white collar job; work
   stress; worker
ID JOB CONTENT QUESTIONNAIRE; INSOMNIA SEVERITY INDEX; EFFORT-REWARD
   IMBALANCE; SHORT-SLEEP DURATION; ALCOHOL-CONSUMPTION; AMERICAN-COLLEGE;
   METABOLIC SYNDROME; GLUCOSE; HEALTH; VALIDATION
AB Aim To examine the prevalence of work stress and prediabetes in computer technology company employees; to analyse the relationships among stress, work stress, and prediabetes; and to explore the potential mediating effects sleep on the relationship between work stress and prediabetes. Design A descriptive, cross-sectional design was used. A convenience sample included employees from a large computer technology company in central Texas. Methods Data collection during March-October 2015 included: retrospective electronic medical record review and online surveys. Electronic medical record review data included: height, weight, waist circumference, blood pressure, high-density lipids, triglycerides, and fasting glucose. Online surveys collected demographic, global stress, diet, exercise, coping, sleep and work stress data from participants. Spearman rho calculations analyzed associations between demographic, socio-cultural factors, health behaviours, work stress, and prediabetes variables. Logistic regression analyses identified probability variables. A structural equation model examined mediating variables. Results Prediabetes prevalence was lower and prevalence of work stress was higher in the participant sample than in the USA population. Findings suggested that low job imbalance increases the probability for prediabetes. Job imbalance was inversely related to prediabetes. Three variables increased the probability prediabetes: alcohol, job imbalance, and sleep. Sleep potentially modified the relationship between job imbalance and prediabetes. Participants were college-educated males working in white-collar, technical jobs. Participants had high rates of work stress. Job imbalance was inversely related to prediabetes, which challenges previous empirical data. Future research should continue to explore the relationship between work stress and prediabetes in this population. Conclusions This study explored the relationship between work stress and prediabetes in a white-collar worker population in technical industry. Findings suggested that workers in industry have a unique type of stress. Nurses who learn to recognize the non-traditional risk factors for prediabetes can improve screening for prediabetes by including work stress and poor sleep questions.
C1 [Reynolds, Raquel Yvonne] MGH Inst Hlth Profess, Sch Nursing, 36 First Ave, Boston, MA 02129 USA.
C3 Harvard University; Harvard University Medical Affiliates; Massachusetts
   General Hospital; MGH Institute of Health Professions
RP Reynolds, RY (corresponding author), MGH Inst Hlth Profess, Sch Nursing, 36 First Ave, Boston, MA 02129 USA.
EM rreynolds@mghihp.edu
OI Reynolds, Raquel/0000-0002-1482-337X
FU University of Texas, School of Nursing [2014-02-0011]
FX The author wishes to acknowledge The University of Texas, School of
   Nursing for supporting this research. The study number was 2014-02-0011.
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NR 67
TC 0
Z9 0
U1 0
U2 11
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0309-2402
EI 1365-2648
J9 J ADV NURS
JI J. Adv. Nurs.
PD MAR
PY 2020
VL 76
IS 3
BP 803
EP 813
DI 10.1111/jan.14276
EA JAN 2020
PG 11
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA KK1BX
UT WOS:000506174800001
PM 31773753
OA Green Submitted
DA 2025-06-11
ER

PT S
AU Chakraborty, S
   Bhattacharyya, R
   Banerjee, D
AF Chakraborty, Surajit
   Bhattacharyya, Rajasri
   Banerjee, Dibyajyoti
BE Makowski, GS
TI Infections: A Possible Risk Factor for Type 2 Diabetes
SO ADVANCES IN CLINICAL CHEMISTRY, VOL 80
SE Advances in Clinical Chemistry
LA English
DT Review; Book Chapter
ID HELICOBACTER-PYLORI INFECTION; RETINOL-BINDING-PROTEIN;
   VITAMIN-D-RECEPTOR; C VIRUS-INFECTION; MUSCLE INSULIN-RESISTANCE;
   FASTING PLASMA-GLUCOSE; OXIDATIVE STRESS; INFLAMMATORY CYTOKINES;
   CHLAMYDIA-PNEUMONIAE; METABOLIC SYNDROME
AB Diabetes mellitus is one of the biggest challenges to human health globally, with an estimated 95% of the global diabetic population having type 2 diabetes. Classical causes for type 2 diabetes, such as genetics and obesity, do not account for the high incidence of the disease. Recent data suggest that infections may precipitate insulin resistance via multiple mechanisms, such as the proinflammatory cytokine response, the acute-phase response, and the alteration of the nutrient status. Even pathogen products, such as lipopolysaccharide and peptidoglycans, can be diabetogenic. Therefore, we argue that infections that are known to contribute to insulin resistance should be considered as risk factors for type 2 diabetes.
C1 [Chakraborty, Surajit; Banerjee, Dibyajyoti] Postgrad Inst Med Educ & Res PGIMER, Chandigarh, India.
   [Bhattacharyya, Rajasri] Maharishi Markandeshwar Univ, Mullana, Ambala, India.
C3 Post Graduate Institute of Medical Education & Research (PGIMER),
   Chandigarh; Maharishi Markandeshwar University
RP Banerjee, D (corresponding author), Postgrad Inst Med Educ & Res PGIMER, Chandigarh, India.
EM dibyajyoti5200@yahoo.co.in
RI Chakraborty, Surajit/IXD-2458-2023
OI Chakraborty, Surajit/0009-0002-5575-4099
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NR 144
TC 20
Z9 27
U1 0
U2 9
PU ELSEVIER ACADEMIC PRESS INC
PI SAN DIEGO
PA 525 B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0065-2423
EI 2162-9471
BN 978-0-12-812075-0
J9 ADV CLIN CHEM
JI Advan. Clin. Chem.
PY 2017
VL 80
BP 227
EP 251
DI 10.1016/bs.acc.2016.11.004
PG 25
WC Medical Laboratory Technology
WE Book Citation Index – Science (BKCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA BI8DN
UT WOS:000414985800007
PM 28431641
DA 2025-06-11
ER

PT J
AU Gasmi, A
   Bjorklund, G
   Mujawdiya, PK
   Semenova, Y
   Piscopo, S
   Peana, M
AF Gasmi, Amin
   Bjorklund, Geir
   Mujawdiya, Pavan Kumar
   Semenova, Yuliya
   Piscopo, Salva
   Peana, Massimiliano
TI Coenzyme Q10 in aging and disease
SO CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
LA English
DT Review
DE Coenzyme Q(10); aging; disease
ID BREAST-CANCER PATIENTS; PLACEBO-CONTROLLED TRIAL; PARA-AMINOBENZOIC
   ACID; DOUBLE-BLIND; VITAMIN-E; MITOCHONDRIAL DYSFUNCTION; INFLAMMATORY
   MARKERS; OXIDATIVE STRESS; FATIGUE-SYNDROME; Q BIOSYNTHESIS
AB Coenzyme Q(10) (CoQ(10)) is an essential component of the electron transport chain. It also acts as an antioxidant in cellular membranes. It can be endogenously produced in all cells by a specialized mitochondrial pathway. CoQ(10) deficiency, which can result from aging or insufficient enzyme function, has been considered to increase oxidative stress. Some drugs, including statins and bisphosphonates, often used by older individuals, can interfere with enzymes responsible for endogenous CoQ(10) synthesis. Oral supplementation with high doses of CoQ(10) can increase both its circulating and intracellular levels and several clinical trials observed that its administration provided beneficial effects on different disorders such as cardiovascular disease and inflammation which have been associated with low CoQ(10) levels and high oxidative stress. Moreover, CoQ(10) has been suggested as a promising therapeutic agent to prevent and slow the progression of other diseases including metabolic syndrome and type 2 diabetes, neurodegenerative and male infertility. However, there is still a need for further studies and well-designed clinical trials involving a large number of participants undergoing longer treatments to assess the benefits of CoQ(10) for these disorders.
C1 [Gasmi, Amin; Piscopo, Salva] Soc Francophone Nutritherapie & Nutrigenet Appl, Villeurbanne, France.
   [Bjorklund, Geir] Council Nutr & Environm Med CONEM, Mo I Rana, Norway.
   [Mujawdiya, Pavan Kumar] Birla Inst Technol & Sci Pilani, Hyderabad, India.
   [Semenova, Yuliya] Nazarbayev Univ, Sch Med, Astana, Kazakhstan.
   [Peana, Massimiliano] Univ Sassari, Dept Chem Phys Math & Nat Sci, Sassari, Italy.
C3 Birla Institute of Technology & Science Pilani (BITS Pilani); Nazarbayev
   University; University of Sassari
RP Bjorklund, G (corresponding author), Council Nutr & Environm Med CONEM, Mo I Rana, Norway.
EM bjorklund@conem.org
RI Mujawdiya, Pavan/HJG-7443-2022; Semenova, Yuliya/HIR-1623-2022; Gasmi,
   Amin/AAL-3595-2020; Peana, Massimiliano Francesco/B-6854-2014;
   Bjorklund, Geir/B-7319-2014
OI Peana, Massimiliano Francesco/0000-0002-3306-0419; Mujawdiya,
   Pavan/0000-0003-2437-1263; Bjorklund, Geir/0000-0003-2632-3935; Gasmi,
   Amin/0000-0003-2165-8373
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NR 106
TC 15
Z9 15
U1 2
U2 16
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1040-8398
EI 1549-7852
J9 CRIT REV FOOD SCI
JI Crit. Rev. Food Sci. Nutr.
PD MAY 6
PY 2024
VL 64
IS 12
BP 3907
EP 3919
DI 10.1080/10408398.2022.2137724
EA OCT 2022
PG 13
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA OK8A1
UT WOS:000874711900001
PM 36300654
DA 2025-06-11
ER

PT J
AU Zhang, X
   Li, JP
   Yang, B
   Leng, QN
   Li, J
   Wang, XT
   Lu, JY
   Olatunji, OJ
   Tang, J
AF Zhang, Xiao
   Li, Jinpeng
   Yang, Bo
   Leng, Qina
   Li, Ji
   Wang, Xintuan
   Lu, Junyao
   Olatunji, Opeyemi Joshua
   Tang, Jian
TI Alleviation of Liver Dysfunction, Oxidative Stress, and Inflammation
   Underlines the Protective Effects of Polysaccharides from Cordyceps
   cicadae on High Sugar/High Fat Diet-Induced Metabolic Syndrome in
   Rats
SO CHEMISTRY & BIODIVERSITY
LA English
DT Article
DE Cordyceps cicadae; polysaccharide; anti-obesity effect; insulin
   resistance; oxidative stress
AB This study investigated the protective effects of two polysaccharides (CPA-1 and CPB-2) from Cordyceps cicadae against high fructose/high fat diet (HF/HFD) induced obesity and metabolic disorders in rats. Rats were either fed with normal diet or HF/HFD and treated with CPA-1 and CPB-2 (100 and 300 mg/kg) for 11 weeks. Administration of CPA-1 and CPB-2 significantly and dose dependently reduced body and liver weight, insulin and glucose tolerance, serum insulin and glucose levels. Furthermore, serum and hepatic lipid profiles, liver function enzymes and proinflammatory cytokines (TNF-alpha, IL-1 beta and IL-6) were markedly reduced. Additionally, CPA-1 and CPB-2 treatment alleviated hepatic oxidative stress by reducing lipid peroxidation level (MDA) and upregulating glutathione peroxidase (GSH-Px), superoxide dismutase (SOD) and catalase (CAT) activities as well as ameliorated histological alterations through the reduction of hepatic lipid accumulation. These results suggested that the polysaccharides from C. cicadae showed protective effects against HF/HFD induced metabolic disturbances and may be considered as a dietary supplement for treating obesity.
C1 [Zhang, Xiao] Linyi Cent Hosp, Dept Med Cosmetol, Linyi 276400, Shandong, Peoples R China.
   [Li, Jinpeng] Shandong First Med Univ & Shandong Acad Med Sci, Shandong Canc Hosp & Inst, Intervent Therapy Dept Ward 1, Jinan 250117, Peoples R China.
   [Yang, Bo] Peoples Hosp Zhaoyuan City, Dept Emergency, Zhaoyuan 265400, Peoples R China.
   [Leng, Qina] Peoples Hosp Zhaoyuan City, Urinary Surg, Zhaoyuan 265400, Peoples R China.
   [Li, Ji] Peoples Hosp Hechuan, Dept Hepatobiliary Surg, Chongqing 401520, Peoples R China.
   [Wang, Xintuan] First Peoples Hosp Xianyang, Dept Hepatobiliary Surg, Xianyang 712000, Peoples R China.
   [Lu, Junyao] Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Sch Med, Dept Infect Dis, Shanghai 201900, Peoples R China.
   [Olatunji, Opeyemi Joshua] Prince Songkla Univ, Fac Thai Tradit Med, Hat Yai 90110, Thailand.
   [Tang, Jian] Bozhou Univ, Sch Chinese Med, Bozhou 236800, Peoples R China.
C3 Shandong First Medical University & Shandong Academy of Medical
   Sciences; Shanghai Jiao Tong University; Prince of Songkla University;
   Bozhou University
RP Lu, JY (corresponding author), Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Sch Med, Dept Infect Dis, Shanghai 201900, Peoples R China.
EM lujunyao1986@sina.com
RI zhang, bx/HNR-3314-2023; Olatunji, Opeyemi/L-2691-2018
OI Olatunji, Opeyemi Joshua/0000-0002-6800-4919
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NR 51
TC 21
Z9 24
U1 3
U2 49
PU WILEY-V C H VERLAG GMBH
PI WEINHEIM
PA POSTFACH 101161, 69451 WEINHEIM, GERMANY
SN 1612-1872
EI 1612-1880
J9 CHEM BIODIVERS
JI Chem. Biodivers.
PD MAY
PY 2021
VL 18
IS 5
DI 10.1002/cbdv.202100065
EA APR 2021
PG 12
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA SD1ON
UT WOS:000640647700001
PM 33738897
DA 2025-06-11
ER

PT J
AU Oudot, C
   Lajoix, AD
   Jover, B
   Rugale, C
AF Oudot, Carole
   Lajoix, Anne D.
   Jover, Bernard
   Rugale, Caroline
TI Dietary sodium restriction prevents kidney damage in high fructose-fed
   rats
SO KIDNEY INTERNATIONAL
LA English
DT Article
DE albuminuria; dietary sodium; IL-6; insulin resistance; oxidative stress;
   TNF-alpha
ID RENIN-ANGIOTENSIN SYSTEM; TUMOR-NECROSIS-FACTOR; ADIPOSE-TISSUE
   DYSFUNCTION; KAPPA-B ACTIVATION; INSULIN-RESISTANCE; OXIDATIVE STRESS;
   METABOLIC SYNDROME; PODOCYTE INJURY; BLOOD-PRESSURE; NADPH OXIDASE
AB Sodium depletion has a protective effect on target-organ damage in hypertension independent of blood pressure. Here we tested whether chronic dietary sodium restriction may prevent the development of renal alterations associated with insulin resistance by reducing the inflammatory and oxidant state. Rats were fed normal-salt-60% fructose, low-salt-60% fructose, or control normal-salt diet for 12 weeks. Insulin resistance induced by high-fructose diet was associated with an increase in albuminuria, tubular and glomerular hypertrophy, and inflammation of kidney and adipose tissue. The low-salt diet improved insulin sensitivity and prevented kidney damage. These beneficial effects of sodium depletion were associated with a decrease in renal inflammation (macrophage infiltration, IL-6, TNF-alpha) and oxidative stress (NADPH oxidase activity), and a prevention of histologic changes in retroperitoneal fat induced by high fructose. Thus, dietary salt depletion has beneficial effects on renal and metabolic alterations associated with a high-fructose diet in rats. Kidney International (2013) 83, 674-683; doi:10.1038/ki.2012.478; published online 23 January 2013
C1 [Oudot, Carole; Lajoix, Anne D.; Jover, Bernard; Rugale, Caroline] Univ Montpellier, CNRS, FRE3400, Grp Rein & Hypertens, F-34059 Montpellier, France.
C3 Centre National de la Recherche Scientifique (CNRS); Universite de
   Montpellier
RP Rugale, C (corresponding author), CNRS, Grp Rein & Hypertens, FRE3400, 641 Ave Doyen GIRAUD, F-34093 Montpellier 5, France.
EM caroline.rugale@inserm.fr
OI JOVER, Bernard/0000-0001-5826-5755
FU La Fondation de Recherche sur l'Hypertension Arterielle
FX We are grateful to Chantal Cazevieille and Cecile Sanchez for their
   technical assistance and interpreting data concerning ultrastructural
   evaluation. CO and this research were supported by 'La Fondation de
   Recherche sur l'Hypertension Arterielle.'
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NR 57
TC 44
Z9 50
U1 0
U2 14
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0085-2538
EI 1523-1755
J9 KIDNEY INT
JI Kidney Int.
PD APR
PY 2013
VL 83
IS 4
BP 674
EP 683
DI 10.1038/ki.2012.478
PG 10
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 117HY
UT WOS:000316945400018
PM 23344470
OA Bronze
DA 2025-06-11
ER

PT J
AU Mirzababaei, A
   Mahmoodi, M
   Keshtkar, A
   Ashraf, H
   Abaj, F
   Soveid, N
   Hajmir, MM
   Radmehr, M
   Khalili, P
   Mirzaei, K
AF Mirzababaei, Atieh
   Mahmoodi, Maryam
   Keshtkar, Abbasali
   Ashraf, Haleh
   Abaj, Faezeh
   Soveid, Neda
   Hajmir, Mahya Mehri
   Radmehr, Mina
   Khalili, Pardis
   Mirzaei, Khadijeh
TI Serum levels of trimethylamine N-oxide and kynurenine novel biomarkers
   are associated with adult metabolic syndrome and its components: a
   case-control study from the TEC cohort
SO FRONTIERS IN NUTRITION
LA English
DT Article
DE kynurenine; trimethylamine N-oxide; metabolic syndrome; dysbiosis 2; gut
   microbiota metabolites
ID CARDIOVASCULAR RISK; GUT MICROBIOTA; INFLAMMASOME ACTIVATION;
   TRYPTOPHAN-METABOLISM; ACID; AGE; ATHEROSCLEROSIS; DYSREGULATION;
   DYSFUNCTION; STRESS
AB Background Epidemiologic research suggests that gut microbiota alteration (dysbiosis) may play a role in the pathogenesis of metabolic syndrome (MetS). Dysbiosis can influence Trimethylamine N-oxide (TMAO) a gut microbiota-derived metabolite, as well as kynurenine pathways (KP), which are known as a new marker for an early predictor of chronic diseases. Hence, the current study aimed to investigate the association between KYN and TMAO with MetS and its components. Methods This case-control study was conducted on 250 adults aged 18 years or over of Tehran University of Medical Sciences (TUMS) Employee's Cohort study (TEC) in the baseline phase. Data on the dietary intakes were collected using a validated dish-based food frequency questionnaire (FFQ) and dietary intakes of nitrite and nitrate were estimated using FFQ with 144 items. MetS was defined according to the NCEP ATP criteria. Serum profiles TMAO and KYN were measured by standard protocol. Result The mean level of TMAO and KYN in subjects with MetS was 51.49 pg/mL and 417.56 nmol/l. High levels of TMAO (>= 30.39 pg/mL) with MetS were directly correlated, after adjusting for confounding factors, the odds of MetS in individuals 2.37 times increased (OR: 2.37, 95% CI: 1.31-4.28, P-value = 0.004), also, high levels of KYN (>= 297.18 nmol/L) increased odds of Mets+ 1.48 times, which is statistically significant (OR: 1.48, 95% CI: 0.83-2.63, P-value = 0.04). High levels of TMAO compared with the reference group increased the odds of hypertriglyceridemia and low HDL in crude and adjusted models (P < 0.05). Additionally, there was a statistically significant high level of KYN increased odds of abdominal obesity (P < 0.05). Conclusion Our study revealed a positive association between serum TMAO and KYN levels and MetS and some of its components. For underlying mechanisms and possible clinical implications of the differences. Prospective studies in healthy individuals are necessary.
C1 [Mirzababaei, Atieh; Soveid, Neda; Hajmir, Mahya Mehri; Mirzaei, Khadijeh] Univ Tehran Med Sci, Dept Community Nutr, Sch Nutr Sci & Dietet, Tehran, Iran.
   [Mahmoodi, Maryam] Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Cellular & Mol Nutr, Tehran, Iran.
   [Keshtkar, Abbasali] Univ Tehran Med Sci, Sch Publ Hlth, Dept Disaster & Emergency Hlth, Tehran, Iran.
   [Ashraf, Haleh] Univ Tehran Med Sci, Cardiovasc Dis Res Inst, Cardiac Primary Prevent Res Ctr, Tehran, Iran.
   [Abaj, Faezeh] Monash Univ, Sch Clin Sci, Dept Nutr Dietet & Food, Monash Hlth, Clayton, Vic, Australia.
   [Radmehr, Mina; Khalili, Pardis] Islamic Azad Univ, Dept Nutr, Sci & Res Branch, Tehran, Iran.
C3 Tehran University of Medical Sciences; Tehran University of Medical
   Sciences; Tehran University of Medical Sciences; Tehran University of
   Medical Sciences; Monash University; Monash Health; Islamic Azad
   University
RP Mirzaei, K (corresponding author), Univ Tehran Med Sci, Dept Community Nutr, Sch Nutr Sci & Dietet, Tehran, Iran.
EM mirzaei_kh@sina.tums.ac.ir
RI Mirzaei, Khadijeh/D-5408-2018; Abaj, Faezeh/ABA-8101-2021; Mirzababaee,
   Atieh/AAQ-7191-2020; Keshtkar, Abbasali/D-2691-2014
OI Ashraf, Haleh/0000-0001-6687-995X
FU Tehran University of Medical Sciences [1401-2-212-58098]
FX The author(s) declare financial support was received for the research,
   authorship, and/or publication of this article. This study was supported
   by the Tehran University of Medical Sciences (Grant No:
   1401-2-212-58098).
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NR 75
TC 4
Z9 4
U1 1
U2 4
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD JAN 23
PY 2024
VL 11
AR 1326782
DI 10.3389/fnut.2024.1326782
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA HD6J4
UT WOS:001157592400001
PM 38321994
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Liu, IF
   Lin, TC
   Wang, SC
   Yen, CH
   Li, CY
   Kuo, HF
   Hsieh, CC
   Chang, CY
   Chang, CR
   Chen, YH
   Liu, YR
   Lee, TY
   Huang, CY
   Hsu, CH
   Lin, SJ
   Liu, PL
AF Liu, I. -Fan
   Lin, Tzu-Chieh
   Wang, Shu-Chi
   Yen, Chia-Hung
   Li, Chia-Yang
   Kuo, Hsuan-Fu
   Hsieh, Chong-Chao
   Chang, Chia-Yuan
   Chang, Chuang-Rung
   Chen, Yung-Hsiang
   Liu, Yu-Ru
   Lee, Tsung-Ying
   Huang, Chi-Yuan
   Hsu, Chih-Hsin
   Lin, Shing-Jong
   Liu, Po-Len
TI Long-term administration of Western diet induced metabolic syndrome in
   mice and causes cardiac microvascular dysfunction, cardiomyocyte
   mitochondrial damage, and cardiac remodeling involving caveolae and
   caveolin-1 expression
SO BIOLOGY DIRECT
LA English
DT Article
DE Metabolic syndrome; Caveolae; Caveolin-1; Endothelial dysfunction;
   Mitochondrial remodeling; Cardiac mitochondria dysfunction
ID ENDOTHELIAL DYSFUNCTION; TRANSPORT; INFLAMMATION; STRESS
AB BackgroundLong-term consumption of an excessive fat and sucrose diet (Western diet, WD) has been considered a risk factor for metabolic syndrome (MS) and cardiovascular disease. Caveolae and caveolin-1 (CAV-1) proteins are involved in lipid transport and metabolism. However, studies investigating CAV-1 expression, cardiac remodeling, and dysfunction caused by MS, are limited. This study aimed to investigate the correlation between the expression of CAV-1 and abnormal lipid accumulation in the endothelium and myocardium in WD-induced MS, and the occurrence of myocardial microvascular endothelial cell dysfunction, myocardial mitochondrial remodeling, and damage effects on cardiac remodeling and cardiac function.MethodsWe employed a long-term (7 months) WD feeding mouse model to measure the effect of MS on caveolae/vesiculo-vacuolar organelle (VVO) formation, lipid deposition, and endothelial cell dysfunction in cardiac microvascular using a transmission electron microscopy (TEM) assay. CAV-1 and endothelial nitric oxide synthase (eNOS) expression and interaction were evaluated using real-time polymerase chain reaction, Western blot, and immunostaining. Cardiac mitochondrial shape transition and damage, mitochondria-associated endoplasmic reticulum membrane (MAM) disruption, cardiac function change, caspase-mediated apoptosis pathway activation, and cardiac remodeling were examined using TEM, echocardiography, immunohistochemistry, and Western blot assay.ResultsOur study demonstrated that long-term WD feeding caused obesity and MS in mice. In mice, MS increased caveolae and VVO formation in the microvascular system and enhanced CAV-1 and lipid droplet binding affinity. In addition, MS caused a significant decrease in eNOS expression, vascular endothelial cadherin, and beta-catenin interactions in cardiac microvascular endothelial cells, accompanied by impaired vascular integrity. MS-induced endothelial dysfunction caused massive lipid accumulation in the cardiomyocytes, leading to MAM disruption, mitochondrial shape transition, and damage. MS promoted brain natriuretic peptide expression and activated the caspase-dependent apoptosis pathway, leading to cardiac dysfunction in mice.ConclusionMS resulted in cardiac dysfunction, remodeling by regulating caveolae and CAV-1 expression, and endothelial dysfunction. Lipid accumulation and lipotoxicity caused MAM disruption and mitochondrial remodeling in cardiomyocytes, leading to cardiomyocyte apoptosis and cardiac dysfunction and remodeling.
C1 [Liu, I. -Fan; Lin, Shing-Jong] Natl Yang Ming Chiao Tung Univ, Inst Clin Med, Taipei 112304, Taiwan.
   [Liu, I. -Fan] Cheng Hsin Gen Hosp, Heart Ctr, Taipei 112401, Taiwan.
   [Lin, Tzu-Chieh; Hsieh, Chong-Chao] Kaohsiung Med Univ, Grad Inst Clin Med, Coll Med, Kaohsiung 807378, Taiwan.
   [Lin, Tzu-Chieh; Kuo, Hsuan-Fu] Kaohsiung Med Univ, Dept Internal Med, Div Cardiol, Kaohsiung 807378, Taiwan.
   [Wang, Shu-Chi] Kaohsiung Med Univ, Dept Med Lab Sci & Biotechnol, Kaohsiung 807378, Taiwan.
   [Yen, Chia-Hung] Kaohsiung Med Univ, Grad Inst Nat Prod, Coll Pharm, Kaohsiung 807378, Taiwan.
   [Li, Chia-Yang; Kuo, Hsuan-Fu] Kaohsiung Med Univ, Grad Inst Med, Coll Med, Kaohsiung 807378, Taiwan.
   [Kuo, Hsuan-Fu] Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Kaohsiung Municipal Ta Tung Hosp, Dept Internal Med, Kaohsiung 807378, Taiwan.
   [Kuo, Hsuan-Fu] Kaohsiung Med Univ, Coll Med, Sch Med, Dept Internal Med, Kaohsiung 807378, Taiwan.
   [Hsieh, Chong-Chao] Kaohsiung Med Univ Hosp, Kaohsiung Med Univ, Dept Surg, Div Cardiovasc Surg, Kaohsiung 807378, Taiwan.
   [Hsieh, Chong-Chao] Kaohsiung Med Univ, Coll Med, Fac Med, Dept Surg, Kaohsiung 807378, Taiwan.
   [Chang, Chia-Yuan] Natl Cheng Kung Univ, Dept Mech Engn, Tainan 701401, Taiwan.
   [Chang, Chuang-Rung] Natl Tsing Hua Univ, Dept Med Sci, Hsinchu 300044, Taiwan.
   [Chang, Chuang-Rung] Natl Tsing Hua Univ, Inst Biotechnol, Hsinchu 300044, Taiwan.
   [Chen, Yung-Hsiang] China Med Univ, Grad Inst Integrated Med, Coll Chinese Med, Taichung 404333, Taiwan.
   [Chen, Yung-Hsiang] Asia Univ, Coll Med & Hlth Sci, Dept Psychol, Taichung 413305, Taiwan.
   [Lee, Tsung-Ying; Huang, Chi-Yuan; Liu, Po-Len] Kaohsiung Med Univ, Coll Med, Dept Resp Therapy, Kaohsiung 807378, Taiwan.
   [Hsu, Chih-Hsin] Natl Cheng Kung Univ Hosp, Natl Cheng Kung Univ, Coll Med, Dept Internal Med, Tainan 701401, Taiwan.
   [Lin, Shing-Jong] Natl Yang Ming Chiao Tung Univ, Cardiovasc Res Ctr, Taipei 112304, Taiwan.
   [Lin, Shing-Jong] Taipei Vet Gen Hosp, Dept Med Res, Taipei 112201, Taiwan.
   [Lin, Shing-Jong] Taipei Med Univ, Taipei Heart Inst, Taipei 110301, Taiwan.
   [Lin, Shing-Jong] Cheng Hsin Gen Hosp, Heart Ctr, Taipei 112401, Taiwan.
   [Liu, Po-Len] Kaohsiung Med Univ Hosp, Dept Med Res, Kaohsiung 807378, Taiwan.
   [Liu, Po-Len] Kaohsiung Med Univ, Orthopaed Res Ctr, Kaohsiung 807378, Taiwan.
C3 National Yang Ming Chiao Tung University; Cheng Hsin General Hospital;
   Kaohsiung Medical University; Kaohsiung Medical University; Kaohsiung
   Medical University; Kaohsiung Medical University; Kaohsiung Medical
   University; Kaohsiung Medical University; Kaohsiung Medical University
   Hospital; Kaohsiung Medical University; Kaohsiung Medical University;
   Kaohsiung Medical University Hospital; Kaohsiung Medical University;
   National Cheng Kung University; National Tsing Hua University; National
   Tsing Hua University; China Medical University Taiwan; Asia University
   Taiwan; Kaohsiung Medical University; National Cheng Kung University;
   National Cheng Kung University Hospital; National Yang Ming Chiao Tung
   University; Taipei Veterans General Hospital; Cheng Hsin General
   Hospital; Kaohsiung Medical University; Kaohsiung Medical University
   Hospital; Kaohsiung Medical University
RP Lin, SJ (corresponding author), Natl Yang Ming Chiao Tung Univ, Inst Clin Med, Taipei 112304, Taiwan.; Liu, PL (corresponding author), Kaohsiung Med Univ, Coll Med, Dept Resp Therapy, Kaohsiung 807378, Taiwan.; Hsu, CH (corresponding author), Natl Cheng Kung Univ Hosp, Natl Cheng Kung Univ, Coll Med, Dept Internal Med, Tainan 701401, Taiwan.; Lin, SJ (corresponding author), Natl Yang Ming Chiao Tung Univ, Cardiovasc Res Ctr, Taipei 112304, Taiwan.; Lin, SJ (corresponding author), Taipei Vet Gen Hosp, Dept Med Res, Taipei 112201, Taiwan.; Lin, SJ (corresponding author), Taipei Med Univ, Taipei Heart Inst, Taipei 110301, Taiwan.; Lin, SJ (corresponding author), Cheng Hsin Gen Hosp, Heart Ctr, Taipei 112401, Taiwan.; Liu, PL (corresponding author), Kaohsiung Med Univ Hosp, Dept Med Res, Kaohsiung 807378, Taiwan.; Liu, PL (corresponding author), Kaohsiung Med Univ, Orthopaed Res Ctr, Kaohsiung 807378, Taiwan.
EM chihhsinhsu@gmail.com; shingjong88@gmail.com; kisa@kmu.edu.tw
RI Chen, Yung-Hsiang/K-6766-2015; Wang, Chenhao/JQI-4636-2023; chen,
   changhan/K-6713-2018; Chang, ChiaYuan/KJC-7194-2024; Kuo,
   Hsuan-Fu/GVS-2875-2022; Chen, Chien-Hung/AFU-7949-2022; Chang,
   Chuang-Rung/C-1815-2012
OI LI, CHIA-YANG/0000-0001-5689-9850; Chang,
   Chuang-Rung/0000-0002-6124-5429
FU Ministry of Science and Technology,Taiwan, R.O.C
   [MOST109-2314-B-006-094-MY3, MOST109-2314-B-037-111-MY3,
   MOST107-2314-B-037-074]; Kaohsiung Medical University Chung-Ho Memorial
   Hospital [KMUH107-7M18, KMUH108-8M27, KMUH109-9R11]; Kaohsiung Medical
   University [KMU-DK(A)111007]; Kaohsiung Municipal Ta-Tung Hospital
   Research Foundation [KMTTH-108-019, KMTTH-105-015]; National Health
   Research Institutes [NHRI-EX110-10724SC]; China Medical University
   [CMU111-MF-54]
FX This study was supported in part by grants from the Ministry of Science
   and Technology,Taiwan, R.O.C. (grant No. MOST109-2314-B-006-094-MY3,
   MOST109-2314-B-037-111-MY3 and MOST107-2314-B-037-074), the Kaohsiung
   Medical University Chung-Ho Memorial Hospital (grant No. KMUH107-7M18,
   KMUH108-8M27, KMUH109-9R11), Kaohsiung Medical University (grant No.
   KMU-DK(A)111007), the Kaohsiung Municipal Ta-Tung Hospital Research
   Foundation (grant No. KMTTH-108-019 and KMTTH-105-015). National Health
   Research Institutes (NHRI-EX110-10724SC), and China Medical University
   (CMU111-MF-54).
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NR 54
TC 14
Z9 14
U1 0
U2 9
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1745-6150
J9 BIOL DIRECT
JI Biol. Direct
PD MAR 6
PY 2023
VL 18
IS 1
AR 9
DI 10.1186/s13062-023-00363-z
PG 16
WC Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics
GA 9P2PX
UT WOS:000944132000001
PM 36879344
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Wu, Q
   Li, JK
   Zhu, JH
   Sun, XH
   He, D
   Li, J
   Cheng, ZX
   Zhang, XH
   Xu, YY
   Chen, Q
   Zhu, YM
   Lai, MD
AF Wu, Qiong
   Li, Jiankang
   Zhu, Jinghan
   Sun, Xiaohui
   He, Di
   Li, Jun
   Cheng, Zongxue
   Zhang, Xuhui
   Xu, Yuying
   Chen, Qing
   Zhu, Yimin
   Lai, Maode
TI Gamma-glutamyl-leucine levels are causally associated with elevated
   cardio-metabolic risks
SO FRONTIERS IN NUTRITION
LA English
DT Article
DE Gamma-glutamyl-leucine; metabolic risk factors; GWAS; metabolic
   syndrome; Mendelian randomization
ID GENOME-WIDE ASSOCIATION; ATHEROSCLEROSIS RISK; ALCOHOL-CONSUMPTION;
   AFRICAN-AMERICANS; LOCI; HYPERTENSION; INFLAMMATION; METAANALYSIS;
   TRANSFERASE; CYSTEINE
AB ObjectiveGamma-glutamyl dipeptides are bioactive peptides involved in inflammation, oxidative stress, and glucose regulation. Gamma-glutamyl-leucine (Gamma-Glu-Leu) has been extensively reported to be associated with the risk of cardio-metabolic diseases, such as obesity, metabolic syndrome, and type 2 diabetes. However, the causality remains to be uncovered. The aim of this study was to explore the causal-effect relationships between Gamma-Glu-Leu and metabolic risk. Materials and methodsIn this study, 1,289 subjects were included from a cross-sectional survey on metabolic syndrome (MetS) in eastern China. Serum Gamma-Glu-Leu levels were measured by untargeted metabolomics. Using linear regressions, a two-stage genome-wide association study (GWAS) for Gamma-Glu-Leu was conducted to seek its instrumental single nucleotide polymorphisms (SNPs). One-sample Mendelian randomization (MR) analyses were performed to evaluate the causality between Gamma-Glu-Leu and the metabolic risk. ResultsFour SNPs are associated with serum Gamma-Glu-Leu levels, including rs12476238, rs56146133, rs2479714, and rs12229654. Out of them, rs12476238 exhibits the strongest association (Beta = -0.38, S.E. = 0.07 in discovery stage, Beta = -0.29, S.E. = 0.14 in validation stage, combined P-value = 1.04 x 10(-8)). Each of the four SNPs has a nominal association with at least one metabolic risk factor. Both rs12229654 and rs56146133 are associated with body mass index, waist circumference (WC), the ratio of WC to hip circumference, blood pressure, and triglyceride (5 x 10(-5) < P < 0.05). rs56146133 also has nominal associations with fasting insulin, glucose, and insulin resistance index (5 x 10(-5) < P < 0.05). Using the four SNPs serving as the instrumental SNPs of Gamma-Glu-Leu, the MR analyses revealed that higher Gamma-Glu-Leu levels are causally associated with elevated risks of multiple cardio-metabolic factors except for high-density lipoprotein cholesterol and low-density lipoprotein cholesterol (P > 0.05). ConclusionFour SNPs (rs12476238, rs56146133, rs2479714, and rs12229654) may regulate the levels of serum Gamma-Glu-Leu. Higher Gamma-Glu-Leu levels are causally linked to cardio-metabolic risks. Future prospective studies on Gamma-Glu-Leu are required to explain its role in metabolic disorders.
C1 [Wu, Qiong; He, Di; Li, Jun; Cheng, Zongxue; Xu, Yuying; Zhu, Yimin] Zhejiang Univ, Dept Epidemiol & Biostat, Sch Med, Hangzhou, Zhejiang, Peoples R China.
   [Wu, Qiong; He, Di; Li, Jun; Cheng, Zongxue; Xu, Yuying; Zhu, Yimin] Zhejiang Univ, Sir Run Run Shaw Hosp, Dept Resp Dis, Sch Med, Hangzhou, Zhejiang, Peoples R China.
   [Wu, Qiong] Hangzhou Normal Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Hangzhou, Peoples R China.
   [Li, Jiankang] Northwestern Polytech Univ, Inst Med Res, Xian, Peoples R China.
   [Zhu, Jinghan] Southern Med Univ, Sch Clin Med 2, Guangzhou, Peoples R China.
   [Sun, Xiaohui] Zhejiang Chinese Med Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Hangzhou, Peoples R China.
   [Zhang, Xuhui] Hangzhou Ctr Dis Control & Prevent, Hangzhou, Peoples R China.
   [Zhang, Xuhui] Zhejiang Univ, Affiliated Hangzhou Ctr Dis Control & Prevent, Sch Publ Hlth, Hangzhou, Peoples R China.
   [Chen, Qing] Zhejiang Prov Ctr Dis Control & Prevent, Hangzhou, Peoples R China.
   [Zhu, Yimin] Zhejiang Univ, Canc Ctr, Hangzhou, Peoples R China.
   [Lai, Maode] Zhejiang Univ, Sch Med, Dept Pathol, Key Lab Dis Prote Zhejiang Prov, Hangzhou, Peoples R China.
   [Lai, Maode] China Pharmaceut Univ, Sch Basic Med Sci & Clin Pharm, State Key Lab Nat Med, Nanjing, Peoples R China.
C3 Zhejiang University; Zhejiang University; Hangzhou Normal University;
   Northwestern Polytechnical University; Southern Medical University -
   China; Zhejiang Chinese Medical University; Zhejiang University;
   Zhejiang Provincial Center for Disease Control & Prevention; Zhejiang
   University; Zhejiang University; China Pharmaceutical University
RP Zhu, YM (corresponding author), Zhejiang Univ, Dept Epidemiol & Biostat, Sch Med, Hangzhou, Zhejiang, Peoples R China.; Zhu, YM (corresponding author), Zhejiang Univ, Sir Run Run Shaw Hosp, Dept Resp Dis, Sch Med, Hangzhou, Zhejiang, Peoples R China.; Chen, Q (corresponding author), Zhejiang Prov Ctr Dis Control & Prevent, Hangzhou, Peoples R China.; Zhu, YM (corresponding author), Zhejiang Univ, Canc Ctr, Hangzhou, Peoples R China.; Lai, MD (corresponding author), Zhejiang Univ, Sch Med, Dept Pathol, Key Lab Dis Prote Zhejiang Prov, Hangzhou, Peoples R China.; Lai, MD (corresponding author), China Pharmaceut Univ, Sch Basic Med Sci & Clin Pharm, State Key Lab Nat Med, Nanjing, Peoples R China.
EM qingchen@cdc.zj.cn; zhuym@zju.edu.cn; lmd@cpu.edu.cn
RI Jin, Xin/ABF-1329-2020; 张, 旭晖/HLG-4912-2023
OI Cheng, Zongxue/0000-0002-4687-0920
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NR 53
TC 15
Z9 15
U1 3
U2 23
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD NOV 24
PY 2022
VL 9
AR 936220
DI 10.3389/fnut.2022.936220
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 6T5WY
UT WOS:000893751600001
PM 36505257
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Guzik, TJ
   Cosentino, F
AF Guzik, Tomasz J.
   Cosentino, Francesco
TI Epigenetics and Immunometabolism in Diabetes and Aging
SO ANTIOXIDANTS & REDOX SIGNALING
LA English
DT Review
DE vascular; inflammation; epigenetics; nitric oxide; superoxide; diabetes
ID VASCULAR-DISEASE PATHOPHYSIOLOGY; IMPROVES ENDOTHELIAL FUNCTION;
   EPICARDIAL ADIPOSE-TISSUE; SMOOTH-MUSCLE-CELLS; LONG NONCODING RNAS;
   PROTEIN-KINASE-C; FACTOR-KAPPA-B; OXIDATIVE STRESS; T-CELL;
   INSULIN-RESISTANCE
AB Significance: A strong relationship between hyperglycemia, impaired insulin pathway, and cardiovascular disease in type 2 diabetes (T2D) is linked to oxidative stress and inflammation. Immunometabolic pathways link these pathogenic processes and pose important potential therapeutic targets.
   Recent Advances: The link between immunity and metabolism is bidirectional and includes the role of inflammation in the pathogenesis of metabolic disorders such as T2D, obesity, metabolic syndrome, and hypertension and the role of metabolic factors in regulation of immune cell functions. Low-grade inflammation, oxidative stress, balance between superoxide and nitric oxide, and the infiltration of macrophages, T cells, and B cells in insulin-sensitive tissues lead to metabolic impairment and accelerated aging.
   Critical Issues: Inflammatory infiltrate and altered immune cell phenotype precede development of metabolic disorders. Inflammatory changes are tightly linked to alterations in metabolic status and energy expenditure and are controlled by epigenetic mechanisms.
   Future Directions: A better comprehension of these mechanistic insights is of utmost importance to identify novel molecular targets. In this study, we describe a complex scenario of epigenetic changes and immunometabolism linking to diabetes and aging-associated vascular disease.
C1 [Guzik, Tomasz J.] Univ Glasgow, BHF Ctr Res Excellence, Inst Cardiovasc & Med Res ICAMS, Glasgow, Lanark, Scotland.
   [Guzik, Tomasz J.] Jagiellonian Univ, Coll Med, Lab Translat Med, Dept Internal & Agr Med, Krakow, Poland.
   [Cosentino, Francesco] Karolinska Univ Hosp, Karolinska Inst, Dept Med, Cardiol Unit, SE-17176 Stockholm, Sweden.
C3 University of Glasgow; Jagiellonian University; Collegium Medicum
   Jagiellonian University; Karolinska Institutet; Karolinska University
   Hospital
RP Cosentino, F (corresponding author), Karolinska Univ Hosp, Karolinska Inst, Dept Med, Cardiol Unit, SE-17176 Stockholm, Sweden.
EM francesco.cosentino@ki.se
RI Cosentino, Francesco/AAE-2426-2020; Guzik, Tomasz/AAM-5007-2020
OI Guzik, Tomasz/0000-0002-5039-7849
FU Narodowe Centrum Nauki of Poland [2011/03/B/NZ4/02454]; European
   Research Council [726318]; Marie Curie CIG [631773]; British Heart
   Foundation Centre for Research Excellence [RE/13/5/30177]; Vetenskapra
   det [2016-02706]; Swedish Heart-Lung Foundation [20140360]; Konung
   Gustaf: Vs och Drottning Victorias Frimurarestiftelse; European Research
   Council (ERC) [726318] Funding Source: European Research Council (ERC)
FX This article was supported by grants from Narodowe Centrum Nauki of
   Poland (2011/03/B/NZ4/02454, to T.J.G.); European Research Council
   project No. 726318, Marie Curie CIG (No. 631773), British Heart
   Foundation Centre for Research Excellence (RE/13/5/30177), and from
   Vetenskapra det (No. 2016-02706), Swedish Heart-Lung Foundation
   (20140360), Konung Gustaf: Vs och Drottning Victorias Frimurarestiftelse
   (to F.C.).
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NR 189
TC 63
Z9 65
U1 2
U2 24
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1523-0864
EI 1557-7716
J9 ANTIOXID REDOX SIGN
JI Antioxid. Redox Signal.
PD JUL
PY 2018
VL 29
IS 3
BP 257
EP 274
DI 10.1089/ars.2017.7299
PG 18
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA GJ8QI
UT WOS:000435654500002
PM 28891325
OA Green Published, Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Tung, SEH
   Nasir, MTM
   Chin, YS
   Zalilah, MS
   Zubaidah, JO
   Yim, HS
AF Tung, Serene En Hui
   Nasir, Mohd Taib Mohd
   Chin, Yit Siew
   Zalilah, Mohd Shariff
   Zubaidah, Jamil Osman
   Yim, Hip Seng
TI Psychological Factors and Cardiovascular Disease Risk Factors as
   Mediators of the Relationship between Overweight/Obesity and Cognitive
   Function among School Children in Kuala Lumpur, Malaysia
SO CHILDHOOD OBESITY
LA English
DT Article
DE cardiovascular disease risk factors; children; cognitive function;
   overweight/obesity; psychological factors
ID INSULIN-RESISTANCE; CARDIOMETABOLIC RISK; WORKING-MEMORY; OBESITY;
   ADOLESCENTS; WEIGHT; ASSOCIATION; PERFORMANCE; DEPRESSION
AB Background: Recent research suggests that a negative relationship exists between adiposity and cognitive function in children. However, limited information is known on how they are related. This study aimed to examine the mediators of the relationship between overweight/obesity and cognitive function among school children in Kuala Lumpur, Malaysia.
   Methods: This is a cross-sectional comparison study whereby 225 overweight/obese children matched for age, sex, and ethnicity with 225 normal weight children participated in this study. Body image dissatisfaction, disordered eating, and depressive symptoms were assessed through a self-administered questionnaire. Blood pressure was measured, whereas blood was drawn to determine insulin, high-sensitivity C-reactive protein (hs-CRP), glucose, and lipid profiles. Homeostasis model assessment-estimated insulin resistance (HOMA-IR) was calculated using glucose and insulin levels. Wechsler's Intelligence Scale for Children-Fourth Edition (WISC-IV) was used to assess cognitive function in children. Ordinary least square regression analysis was conducted to determine the direct and indirect relationships between weight status and cognitive function.
   Results: A negative relationship was found between overweight/obesity with cognitive function. Overweight/obese children were on average 4.075 units lower in cognitive function scores compared to normal weight children. Such difference was found through mediators, such as body image dissatisfaction, disordered eating, depression, systolic blood pressure, triglycerides, HOMA-IR, and hs-CRP, contributing 22.2% of the variances in cognitive function in children.
   Conclusion: Results highlight the important mediators of the relationship between overweight/obesity and cognitive function. Consequently, future interventions should target to improve psychological well-being and reduce cardiovascular disease risk for the prevention of poorer cognitive performance in overweight/obese children.
C1 [Tung, Serene En Hui; Yim, Hip Seng] UCSI Univ, Fac Appl Sci, Dept Food Sci & Nutr, Kuala Lumpur 56000, Malaysia.
   [Nasir, Mohd Taib Mohd; Chin, Yit Siew; Zalilah, Mohd Shariff] Univ Putra Malaysia, Fac Med & Hlth Sci, Dept Nutr & Dietet, Serdang, Selangor Darul, Malaysia.
   [Nasir, Mohd Taib Mohd; Chin, Yit Siew; Zalilah, Mohd Shariff] Univ Putra Malaysia, Fac Med & Hlth Sci, Res Ctr Excellence Nutr & Noncommunicable Dis, Serdang, Malaysia.
   [Zubaidah, Jamil Osman] Cyberjaya Univ, Coll Med Sci, Fac Allied Hlth Sci, Div Psychol, Cyberjaya, Malaysia.
C3 UCSI University; Universiti Putra Malaysia; Universiti Putra Malaysia
RP Tung, SEH (corresponding author), UCSI Univ, Fac Appl Sci, Dept Food Sci & Nutr, Kuala Lumpur 56000, Malaysia.
EM serenetung@ucsiuniversity.edu.my
RI Taib, Mohd/G-2524-2015; Yim, Hip/AAM-3207-2020; Chin, Yit/G-2001-2015;
   Tung, Serene En Hui/HCH-0743-2022
OI Mohd Shariff, Zalilah/0000-0002-5347-4627; Tung, Serene En
   Hui/0000-0001-9122-7523
FU UCSI University Research Grant Scheme (RGS) [Proj-In-FAS-016]
FX This work was supported by the UCSI University Research Grant Scheme
   (RGS) (Proj-In-FAS-016). The authors thank all the children involved for
   their participation and cooperation and their parents for permission and
   support in this study. The authors are also grateful to the school
   principals, teachers, administrators, and the Ministry of Education for
   their cooperation and assistance.
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NR 32
TC 5
Z9 5
U1 0
U2 14
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 2153-2168
EI 2153-2176
J9 CHILD OBES
JI Child Obes.
PD JAN
PY 2019
VL 15
IS 1
BP 56
EP 62
DI 10.1089/chi.2018.0066
EA OCT 2018
PG 7
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Pediatrics
GA HR4ZA
UT WOS:000447695600001
PM 30339034
DA 2025-06-11
ER

PT J
AU Huang, H
   Luo, YY
   Wang, Q
   Zhang, YH
   Li, ZX
   He, RK
   Chen, XM
   Dong, ZY
AF Huang, Hui
   Luo, Yayong
   Wang, Qian
   Zhang, Yihan
   Li, Zhongxia
   He, Ruikun
   Chen, Xiangmei
   Dong, Zheyi
TI Vaccinium as Potential Therapy for Diabetes and Microvascular
   Complications
SO NUTRIENTS
LA English
DT Review
DE diabetes mellitus; diabetic kidney disease; diabetic retinopathy;
   Ericaceae; Vaccinium
ID PLANT-BASED DIETS; OXIDATIVE STRESS; INSULIN-RESISTANCE; KIDNEY-DISEASE;
   BLUEBERRY JUICE; HIGH-GLUCOSE; ENDOTHELIAL DYSFUNCTION; METABOLIC
   SYNDROME; GLYCEMIC RESPONSE; CRANBERRY JUICE
AB Diabetes mellitus is one of the most critical global health concerns, with a fast-growing prevalence. The incidence of diabetic vascular complications is also rapidly increasing, exacerbating the burden on individuals with diabetes and the consumption of public medical resources. Despite the overall improvements in the prevention, diagnosis, and treatment of diabetic microvascular complications in recent years, safe and effective alternative or adjunctive therapies are urgently needed. The mechanisms underlying diabetic vascular complications are complex, with hyperglycemia-induced oxidative stress and inflammation being the leading causes. Therefore, glycemic control, antioxidation, and anti-inflammation are considered the main targets for the treatment of diabetes and its vascular comorbidities. Vaccinium L. (Ericaceae) is a genus of plants enriched with polyphenolic compounds in their leaves and fruits. Vaccinium and its extracts have demonstrated good bioactivity in reducing blood glucose, oxidative stress, and inflammation, making them excellent candidates for the management of diabetes and diabetic vascular complications. Here, we review recent preclinical and clinical studies on the potential effect of Vaccinium on ameliorating diabetes and diabetic complications, particularly diabetic kidney disease and diabetic retinopathy.
C1 [Huang, Hui; Luo, Yayong; Wang, Qian; Chen, Xiangmei; Dong, Zheyi] Chinese Peoples Liberat Army Gen Hosp, Nephrol Inst Chinese Peoples Liberat Army, Natl Clin Res Ctr Kidney Dis, State Key Lab Kidney Dis,Beijing Key Lab Kidney Di, Beijing 100853, Peoples R China.
   [Huang, Hui; Luo, Yayong; Chen, Xiangmei] Guangdong Pharmaceut Univ, Sch Clin Med, Guangzhou 510006, Peoples R China.
   [Zhang, Yihan; Li, Zhongxia; He, Ruikun] BYHEALTH Inst Nutr & Hlth, 3 Kehui 3rd St, 99 Kexue Ave Cent, Guangzhou 510663, Peoples R China.
C3 Chinese People's Liberation Army General Hospital; Guangdong
   Pharmaceutical University
RP Chen, XM; Dong, ZY (corresponding author), Chinese Peoples Liberat Army Gen Hosp, Nephrol Inst Chinese Peoples Liberat Army, Natl Clin Res Ctr Kidney Dis, State Key Lab Kidney Dis,Beijing Key Lab Kidney Di, Beijing 100853, Peoples R China.; Chen, XM (corresponding author), Guangdong Pharmaceut Univ, Sch Clin Med, Guangzhou 510006, Peoples R China.
EM xmchen301@126.com; shengdai26@163.com
OI huang, Hui/0009-0006-3209-9342
FU Science and Technology Project of Beijing [Z221100007422121]; Beijing
   Natural Science Foundation [L222133]; Natural Science Foundation of
   China [62250001]
FX This research was funded by the Science and Technology Project of
   Beijing (Z221100007422121), Beijing Natural Science Foundation
   (L222133), and Natural Science Foundation of China (62250001).
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NR 184
TC 8
Z9 8
U1 1
U2 10
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD APR 23
PY 2023
VL 15
IS 9
AR 2031
DI 10.3390/nu15092031
PG 28
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA G1SD5
UT WOS:000987029900001
PM 37432140
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Bartoli, F
   Crocamo, C
   Carrà, G
AF Bartoli, Francesco
   Crocamo, Cristina
   Carra, Giuseppe
TI Metabolic dysfunctions in people with post-traumatic stress disorder
SO JOURNAL OF PSYCHOPATHOLOGY
LA English
DT Review
DE PTSD; metabolic; trauma; neuroendocrinology; inflammation; biomarkers
ID MAJOR DEPRESSIVE DISORDER; SEVERE MENTAL-ILLNESS; ADIPONECTIN LEVELS;
   NEUROPEPTIDE-Y; 2ND-GENERATION ANTIPSYCHOTICS; INTRINSIC EXCITABILITY;
   PLASMA ADIPONECTIN; BIPOLAR DISORDER; RISK; ASSOCIATION
AB Objectives
   The association between post-traumatic stress disorder (PTSD) and metabolic dysfunctions has attracted growing attention in recent years. Understanding and identifying common inflammatory and neuroendocrine mechanisms can help clinicians to improve the treatment and prognosis of these co-occurring conditions.
   Methods
   We conducted an overview, summarizing biological mechanisms and related biomarkers underlying the relationship between PTSD and metabolic dysfunctions
   Results
   Evidence suggests that PTSD may be associated with metabolic abnormalities. Metabolic syndrome in PTSD may impact both cardiovascular health and central nervous system functions. The role of traumatic events in influencing inflammatory and immuno-metabolic systems seems supported by available studies. Exposure to trauma may determine neuroendocrine responses and long-lasting changes in the regulation of the hypothalamic-pituitary-adrenal axis, affecting its physiological activity
   Conclusions
   Dysfunctional adaptation to stress may increase the vulnerability to metabolic abnormalities which, in turn, may favor the occurrence of psychopathological features after traumatic experiences. Approaching PTSD as a systemic condition by assessing, monitoring, and treating metabolic variations may lead to a significant improvement in its management and prognosis. Further research is needed to test novel treatments for PTSD, targeting neuroendocrine and immune-metabolic systems.
C1 [Bartoli, Francesco; Crocamo, Cristina; Carra, Giuseppe] Univ Milano Bicocca, Dept Med & Surg, Piazza Ateneo Nuovo 1, I-20126 Milan, Italy.
   [Bartoli, Francesco; Carra, Giuseppe] ASST Nord Milano, Bassini Hosp, Dept Mental Hlth & Addict, Milan, Italy.
   [Carra, Giuseppe] UCL, Div Psychiat, London, England.
C3 University of Milano-Bicocca; University of London; University College
   London
RP Bartoli, F (corresponding author), Univ Milano Bicocca, Dept Med & Surg, Piazza Ateneo Nuovo 1, I-20126 Milan, Italy.
EM francesco.bartoli@unimib.it
RI Crocamo, Cristina/I-4355-2019; Bartoli, Francesco/K-5755-2016; Crocamo,
   Cristina/B-5404-2014; Carra, Giuseppe/C-6091-2012
OI Bartoli, Francesco/0000-0003-2612-4119; Crocamo,
   Cristina/0000-0002-2979-2107; Carra, Giuseppe/0000-0002-6877-6169
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NR 76
TC 4
Z9 4
U1 0
U2 7
PU PACINI EDITORE
PI PISA
PA VIA DELLA GHERARDESCA-ZONA INDUSTRIALE OSPEDALETTO, 56121 PISA, ITALY
SN 1592-1107
EI 2499-6904
J9 J PSYCHOPATHOL
JI J. Psychopathol.
PD MAR
PY 2020
VL 26
IS 1
SI SI
BP 85
EP 91
DI 10.36148/2284-0249-372
PG 7
WC Psychiatry
WE Emerging Sources Citation Index (ESCI)
SC Psychiatry
GA KK7GN
UT WOS:000512907100012
DA 2025-06-11
ER

PT J
AU Weeth, LP
AF Weeth, Lisa P.
TI Other Risks/Possible Benefits of Obesity
SO VETERINARY CLINICS OF NORTH AMERICA-SMALL ANIMAL PRACTICE
LA English
DT Article
DE Obesity; Hyperlipidemia; Adipokines; Renal; Quality of life
ID QUALITY-OF-LIFE; CHRONIC KIDNEY-DISEASE; RANDOMIZED CONTROLLED-TRIAL;
   CANINE MAMMARY-TUMORS; BODY CONDITION SCORE; WEIGHT-LOSS; FELINE
   OBESITY; RISK-FACTORS; HEART-FAILURE; METABOLIC SYNDROME
AB Obesity is not a cosmetic or social issue; it is an animal health issue. The metabolic effects of obesity on insulin resistance and development of hyperlipidemia and the mechanical stress excess weight places on the musculoskeletal system are well established in the literature. Additional health risks from obesity, such as fatty accumulation in the liver, intestinal bacterial dysbiosis, and changes to renal architecture, are less well understood, but have been demonstrated to occur clinically in obese animals and may lead to deleterious long-term health effects. Keeping dogs and cats lean lowers their risk for development of certain diseases and leads to a longer and better quality of life.
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RP Weeth, LP (corresponding author), Weeth Nutr Serv, 25 Chester St, Edinburgh EH3 7EN, Midlothian, Scotland.
EM weethnutrition@gmail.com
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NR 97
TC 20
Z9 22
U1 1
U2 61
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0195-5616
EI 1878-1306
J9 VET CLIN N AM-SMALL
JI Vet. Clin. N. Am.-Small Anim. Pract.
PD SEP
PY 2016
VL 46
IS 5
BP 843
EP +
DI 10.1016/j.cvsm.2016.04.007
PG 12
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA DV0HY
UT WOS:000382599800008
PM 27267439
DA 2025-06-11
ER

PT J
AU He, ZY
   Lieu, L
   Dong, YB
   Afrin, S
   Chau, D
   Kabahizi, A
   Wallace, B
   Cao, JH
   Hwang, ES
   Yao, T
   Huang, YR
   Okolo, J
   Cheng, B
   Gao, Y
   Hu, L
   Williams, KW
AF He, Zhenyan
   Lieu, Linh
   Dong, Yanbin
   Afrin, Sadia
   Chau, Dominic
   Kabahizi, Anita
   Wallace, Briana
   Cao, Jianhong
   Hwang, Eun-Sang
   Yao, Ting
   Huang, Yiru
   Okolo, Jennifer
   Cheng, Bo
   Gao, Yong
   Hu, Ling
   Williams, Kevin W.
TI PERK in POMC neurons connects celastrol with metabolism
SO JCI INSIGHT
LA English
DT Article
ID ENDOPLASMIC-RETICULUM STRESS; ER STRESS; PROOPIOMELANOCORTIN NEURONS;
   DIABETES-MELLITUS; ENERGY-BALANCE; INSULIN ACTION; LEPTIN ACTION; AGRP
   NEURONS; OBESITY; KINASE
AB ER stress and activation of the unfolded protein response in the periphery as well as the central nervous system have been linked to various metabolic abnormalities. Chemically lowering protein kinase R-like ER kinase (PERK) activity within the hypothalamus leads to decreased food intake and body weight. However, the cell populations required in this response remain undefined. In the current study, we investigated the effects of proopiomelanocortin-specific (POMC-specific) PERK deficiency on energy balance and glucose metabolism. Male mice deficient for PERK in POMC neurons exhibited improvements in energy balance on a high-fat diet, showing decreased food intake and body weight, independent of changes in glucose and insulin tolerances. The plant-based inhibitor of PERK, celastrol, increases leptin sensitivity, resulting in decreased food intake and body weight in a murine model of diet-induced obesity (DIO). Our data extend these observations by demonstrating that celastrol-induced improvements in leptin sensitivity and energy balance were attenuated in mice with PERK deficiency in POMC neurons. Altogether, these data suggest that POMC-specific PERK deficiency in male mice confers protection against DIO, possibly providing a new therapeutic target for the treatment of diabetes and metabolic syndrome.
C1 [He, Zhenyan] Zhengzhou Univ, Dept Neurosurg, Affiliated Tumor Hosp, Zhengzhou, Henan, Peoples R China.
   [He, Zhenyan; Lieu, Linh; Dong, Yanbin; Afrin, Sadia; Chau, Dominic; Kabahizi, Anita; Wallace, Briana; Hwang, Eun-Sang; Okolo, Jennifer; Williams, Kevin W.] Univ Texas Southwestern Med Ctr Dallas, Dept Internal Med, Ctr Hypothalam Res, Dallas, TX 75390 USA.
   [Dong, Yanbin; Hu, Ling] Guangzhou Univ Chinese Med, Inst Gastroenterol, Guangzhou, Guangdong, Peoples R China.
   [Dong, Yanbin; Cao, Jianhong; Cheng, Bo; Hu, Ling] Guangzhou Univ Chinese Med, Sci & Technol Innovat Ctr, Guangzhou, Guangdong, Peoples R China.
   [Yao, Ting] Univ Calif Los Angeles, David Geffen Sch Med, Childrens Discovery & Innovat Inst, Div Pediat Endocrinol,Dept Pediat, Los Angeles, CA 90095 USA.
   [Huang, Yiru] Fudan Univ, Sch Life Sci, State Key Lab Genet Engn, Shanghai, Peoples R China.
   [Gao, Yong] Binzhou Med Coll, Lab Dept, Affiliated Hosp, Yantai, Shandong, Peoples R China.
C3 Zhengzhou University; University of Texas System; University of Texas
   Southwestern Medical Center Dallas; Guangzhou University of Chinese
   Medicine; Guangzhou University of Chinese Medicine; University of
   California System; University of California Los Angeles; University of
   California Los Angeles Medical Center; David Geffen School of Medicine
   at UCLA; Fudan University; Binzhou Medical University
RP Williams, KW (corresponding author), Univ Texas Southwestern Med Ctr Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390 USA.; Hu, L (corresponding author), Guangzhou Univ Chinese Med, 12 Airport Rd, Guangzhou 510405, Peoples R China.
EM drhuling@163.com; kevin.williams@utsouthwestern.edu
RI Williams, Kevin/AAA-4243-2020; Cao, Jianhong/AFC-6942-2022; Yao,
   Ting/HKE-5433-2023; hu, ling/GWC-1104-2022; liang, YU/IYT-4334-2023
OI , Jennifer Okolo/0009-0005-9767-4718; Hwang,
   Eun-Sang/0000-0002-4298-5368; Yao, Ting/0000-0003-4605-6475; Kabahizi,
   Anita/0000-0001-5271-8792; Lieu, Linh/0000-0002-3008-9443; CHENG,
   BO/0000-0002-0869-0769; liang, YU/0009-0007-3922-3454; Williams,
   Kevin/0000-0002-8434-8658
FU NIH [R01 DK100699, R01 DK119169, DK1191305830]; key development and
   promotion project of Henan province [212102310662]; National Institute
   of Diabetes and Digestive and Kidney Diseases [R01DK119169] Funding
   Source: NIH RePORTER
FX This work was supported by NIH grants to KWW (R01 DK100699, R01
   DK119169, and DK1191305830) and the key development and promotion
   project of Henan province (no. 212102310662).
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NR 80
TC 14
Z9 16
U1 1
U2 23
PU AMER SOC CLINICAL INVESTIGATION INC
PI ANN ARBOR
PA 2015 MANCHESTER RD, ANN ARBOR, MI 48104 USA
EI 2379-3708
J9 JCI INSIGHT
JI JCI Insight
PD SEP 22
PY 2021
VL 6
IS 18
AR e145306
DI 10.1172/jci.insight.145306
PG 14
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA UY7ON
UT WOS:000701708700002
PM 34549728
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Zakkar, M
   Ascione, R
   James, AF
   Angelini, GD
   Suleiman, MS
AF Zakkar, M.
   Ascione, R.
   James, A. F.
   Angelini, G. D.
   Suleiman, M. S.
TI Inflammation, oxidative stress and postoperative atrial fibrillation in
   cardiac surgery
SO PHARMACOLOGY & THERAPEUTICS
LA English
DT Review
DE Postoperative atrial fibrillation; Cardiopulmonary bypass; Cardiac
   surgery; Inflammation; Oxidative stress; Ischaemia
ID ARTERY-BYPASS-SURGERY; POLYUNSATURATED FATTY-ACIDS;
   NECROSIS-FACTOR-ALPHA; CARDIOPULMONARY BYPASS; MYOCARDIAL INJURY;
   INHIBITING INFLAMMATION; TRANSCRIPTION FACTOR; CYTOKINE EXPRESSION;
   METABOLIC SYNDROME; ENDOTHELIAL-CELLS
AB Postoperative atrial fibrillation (POAF) is a common complication of cardiac surgery that occurs in up to 60% of patients. POAF is associated with increased risk of cardiovascular mortality, stroke and other arrhythmias that can impact on early and long term clinical outcomes and health economics. Many factors such as disease-induced cardiac remodelling, operative trauma, changes in atrial pressure and chemical stimulation and reflex sympathetic/parasympathetic activation have been implicated in the development of POAF. There is mounting evidence to support a major role for inflammation and oxidative stress in the pathogenesis of POAF. Both are consequences of using cardiopulmonary bypass and reperfusion following ischaemic cardioplegic arrest Subsequently, several anti-inflammatory and antioxidant drugs have been tested in an attempt to reduce the incidence of POAF. However, prevention remains suboptimal and thus far none of the tested drugs has provided sufficient efficacy to be widely introduced in clinical practice. A better understanding of the cellular and molecular mechanisms responsible for the onset and persistence of POAF is needed to develop more effective prediction and interventions. (C) 2015 The Authors. Published by Elsevier Inc.
C1 [Zakkar, M.; Ascione, R.; Angelini, G. D.; Suleiman, M. S.] Univ Bristol, Bristol Heart Inst, Bristol Royal Infirm, Bristol BS2 8HW, Avon, England.
   [James, A. F.] Univ Bristol, Sch Physiol & Pharmacol, Bristol BS8 1TD, Avon, England.
C3 Bristol Royal Infirmary; University of Bristol; University of Bristol
RP Suleiman, MS (corresponding author), Univ Bristol, Sch Clin Sci, Bristol Royal Infirm, Upper Maudlin St, Bristol BS2 8HW, Avon, England.
EM m.s.suleiman@bristol.ac.uk
RI Suleiman, Saadeh/AAF-2946-2019
OI Angelini, Gianni D/0000-0002-1753-3730; Suleiman,
   M.-Saadeh/0000-0001-6080-480X
FU Medical Research Council [MR/L012723/1] Funding Source: Medline; MRC
   [MR/L012723/1] Funding Source: UKRI
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NR 143
TC 187
Z9 200
U1 1
U2 34
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0163-7258
J9 PHARMACOL THERAPEUT
JI Pharmacol. Ther.
PD OCT
PY 2015
VL 154
BP 13
EP 20
DI 10.1016/j.pharmthera.2015.06.009
PG 8
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA CS5VN
UT WOS:000362146500002
PM 26116810
OA hybrid
DA 2025-06-11
ER

PT J
AU Mancini, A
   Festa, R
   Raimondo, S
   Pontecorvi, A
   Littarru, GP
AF Mancini, Antonio
   Festa, Roberto
   Raimondo, Sebastiano
   Pontecorvi, Alfredo
   Littarru, Gian Paolo
TI Hormonal Influence on Coenzyme Q10 Levels in Blood Plasma
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE coenzyme Q(10); thyroid; oxidative stress; antioxidants; pituitary
ID LOW-DENSITY-LIPOPROTEIN; ACUTE MYOCARDIAL-INFARCTION;
   CORONARY-HEART-DISEASE; VITAMIN-E CONSUMPTION; OXIDATIVE STRESS;
   ANTIOXIDANT SYSTEMS; LIPID-PEROXIDATION; METABOLIC SYNDROME;
   HYPERTHYROIDISM; RISK
AB Coenzyme Q(10) (CoQ(10)), also known as ubiquinone for its presence in all body cells, is an essential part of the cell energy-producing system. However, it is also a powerful lipophilic antioxidant protecting lipoproteins and cell membranes. Due to these two actions, CoQ(10) is commonly used in clinical practice in chronic heart failure, male infertility, and neurodegenerative disease. However, it is also taken as an anti-aging substance by healthy people aiming for long-term neuroprotection and by sportsmen to improve endurance. Many hormones are known to be involved in body energy regulation, in terms of production, consumption and dissipation, and their influence on CoQ(10) body content or blood values may represent an important pathophysiological mechanism. We summarize the main findings of the literature about the link between hormonal systems and circulating CoQ(10) levels. In particular the role of thyroid hormones, directly involved in the regulation of energy homeostasis, is discussed. There is also a link with gonadal and adrenal hormones, partially due to the common biosynthetic pathway with CoQ(10), but also to the increased oxidative stress found in hypogonadism and hypoadrenalism.
C1 [Mancini, Antonio; Raimondo, Sebastiano; Pontecorvi, Alfredo] Univ Cattolica Sacro Cuore, Div Endocrinol, Dept Internal Med, I-00168 Rome, Italy.
   [Festa, Roberto] Polytech Univ Marche, Dept Mol & Clin Sci, I-60020 Ancona, Italy.
   [Littarru, Gian Paolo] Polytech Univ Marche, Dept Biol Biochem & Genet, I-60128 Ancona, Italy.
C3 Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli;
   Marche Polytechnic University; Marche Polytechnic University
RP Mancini, A (corresponding author), Univ Cattolica Sacro Cuore, Div Endocrinol, Dept Internal Med, I-00168 Rome, Italy.
EM mancini.giac@mclink.it; festa7r@libero.it; bastio984@hotmail.com;
   a.pontecorvi@rm.unicatt.it; g.littarru@univpm.it
RI Pontecorvi, Alfredo/K-5146-2016
OI PONTECORVI, Alfredo/0000-0003-0570-6865
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NR 41
TC 19
Z9 24
U1 2
U2 8
PU MDPI AG
PI BASEL
PA POSTFACH, CH-4005 BASEL, SWITZERLAND
SN 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD DEC
PY 2011
VL 12
IS 12
BP 9216
EP 9225
DI 10.3390/ijms12129216
PG 10
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 866TD
UT WOS:000298405100056
PM 22272129
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Hopps, E
   Caimi, G
AF Hopps, E.
   Caimi, G.
TI Exercise in obesity management
SO JOURNAL OF SPORTS MEDICINE AND PHYSICAL FITNESS
LA English
DT Article
DE Obesity; Physical exercise; Insulin resistance Inflammation
ID C-REACTIVE PROTEIN; INDUCED WEIGHT-LOSS; PHYSICAL-ACTIVITY; METABOLIC
   SYNDROME; INSULIN-RESISTANCE; ADIPOSE-TISSUE; INFLAMMATORY MARKERS;
   ABDOMINAL OBESITY; OXIDATIVE STRESS; VISCERAL FAT
AB Obesity is considered a global epidemic by the World Health Organization in both developed and developing countries. It is associated with a higher risk of cardiovascular disease, diabetes mellitus, cancer and other clinical conditions. Visceral fat is the major responsible for metabolic complications, such as insulin-resistance, and it acts as an endocrine organ producing adipokines involved in lipidic and glycaemic metabolism. TNF-a and IL-6, produced by adipose tissue, increase NADPH oxidase activity activating protein kinase C and NFB leading to an higher oxidative stress. The obesity management includes physical activity: aerobic training improves lipid profile and insulin sensitivity while resistance training increases lean body mass and basal metabolism and has beneficial effects on bone mineral density and glucose tolerance. An exercise program should include 30 to 45 minutes of moderate intensity activity performed 3 to 5 days a week. Weight loss is also associated with lower blood pressure and improved oxidative status, confirmed by reduced oxidative stress markers and increased antioxidant protection. An inverse association between indicators of systemic inflammation and physical activity has been demonstrated, so exercise training may reduce endothelial damage and cardiovascular risk.
C1 [Hopps, E.; Caimi, G.] Univ Palermo, Dept Internal Med Cardiovasc & Nephrol Dis, Palermo, Italy.
C3 University of Palermo
RP Hopps, E (corresponding author), Via Vespro 129, I-90100 Palermo, Italy.
EM euhopps@libero.it
OI Caimi, Gregorio/0000-0001-8964-255X
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NR 72
TC 14
Z9 19
U1 3
U2 25
PU EDIZIONI MINERVA MEDICA
PI TURIN
PA CORSO BRAMANTE 83-85 INT JOURNALS DEPT., 10126 TURIN, ITALY
SN 0022-4707
EI 1827-1928
J9 J SPORT MED PHYS FIT
JI J. Sports Med. Phys. Fit.
PD JUN
PY 2011
VL 51
IS 2
BP 275
EP 282
PG 8
WC Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Sport Sciences
GA 816IY
UT WOS:000294593100014
PM 21681163
DA 2025-06-11
ER

PT J
AU Chen, J
   Goligorsky, MS
AF Chen, J
   Goligorsky, MS
TI Premature senescence of endothelial cells: Methusaleh's dilemma
SO AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
LA English
DT Review
DE stress-induced premature senescence; endothelial progenitor cell;
   vasculopathy; metabolic syndrome; nephropathy
ID GLYCATION END-PRODUCTS; HUMAN-DIPLOID FIBROBLASTS; PLASMINOGEN-ACTIVATOR
   INHIBITOR; NITRIC-OXIDE SYNTHASE; PROGENITOR CELLS; CELLULAR SENESCENCE;
   OXIDATIVE STRESS; BONE-MARROW; STEM-CELLS; REPLICATIVE SENESCENCE
AB Senescence has been considered a programmed cellular response, parallel to apoptosis, that is turned on when a cell reaches Hayflick's limit. Once cells enter the senescence program, they cease to proliferate and undergo a series of morphological and functional changes. Studies support a central role for Rb protein in controlling this process after it receives senescent signals from the p53 and p16 pathways. Cellular senescence is considered an essential contributor to the aging process and has been shown to be an important tumor suppression mechanism. In addition, emerging evidence suggests that senescence may also be involved in the pathogenesis of stem cell dysfunction and chronic human diseases. Under these circumstances cells undergo stress-induced premature senecence, which has several specific features. Focusing on endothelial cells, we discuss recent advances in our understanding of the stresses and their pathways that prompt the premature senescence response, evaluate their correlation with the apoptotic response, and examine their links to the development of chronic diseases and the impaired function of endothelial progenitor cells, with the emphasis on vasculopathy. Emerging novel therapeutic interventions based on recent experimental findings are also reviewed.
C1 New York Med Coll, Renal Res Inst, Dept Med, Valhalla, NY 10595 USA.
   New York Med Coll, Renal Res Inst, Dept Pharmacol, Valhalla, NY 10595 USA.
C3 New York Medical College; Renal Research Institute; New York Medical
   College; Renal Research Institute
RP New York Med Coll, Renal Res Inst, Dept Med, Valhalla, NY 10595 USA.
EM jun_chen@nymc.edu; Michael_goligorsky@nymc.edu
FU NIDDK NIH HHS [DK-45462, DK-54602, DK-52783] Funding Source: Medline
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NR 161
TC 102
Z9 114
U1 0
U2 9
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0363-6135
EI 1522-1539
J9 AM J PHYSIOL-HEART C
JI Am. J. Physiol.-Heart Circul. Physiol.
PD MAY
PY 2006
VL 290
IS 5
BP H1729
EP H1739
DI 10.1152/ajpheart.01103.2005
PG 11
WC Cardiac & Cardiovascular Systems; Physiology; Peripheral Vascular
   Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Physiology
GA 030WD
UT WOS:000236664900001
PM 16603702
DA 2025-06-11
ER

PT J
AU Murray, A
   Tharmalingam, S
   Nguyen, P
   Tai, TC
AF Murray, Alyssa
   Tharmalingam, Sujeenthar
   Phong Nguyen
   Tai, T. C.
TI Untargeted metabolomics reveals sex-specific differences in lipid
   metabolism of adult rats exposed to dexamethasone in utero
SO SCIENTIFIC REPORTS
LA English
DT Article
ID INFANT ORIGINS; FETAL; STRESS; MECHANISMS; COORDINATION; EXPRESSION;
   CARNITINE
AB Prenatal stress through glucocorticoid (GC) exposure leads to an increased risk of developing diseases such as cardiovascular disease, metabolic syndrome and hypertension in adulthood. We have previously shown that administration of the synthetic glucocorticoid, dexamethasone (Dex), to pregnant Wistar-Kyoto dams produces offspring with elevated blood pressures and disrupted circadian rhythm signaling. Given the link between stress, circadian rhythms and metabolism, we performed an untargeted metabolomic screen on the livers of offspring to assess potential changes induced by prenatal Dex exposure. This metabolomic analysis highlighted 18 significantly dysregulated metabolites in females and 12 in males. Pathway analysis using MetaboAnalyst 4.0 highlighted key pathway-level metabolic differences: glycerophospholipid metabolism, purine metabolism and glutathione metabolism. Gene expression analysis revealed significant upregulation of several lipid metabolism genes in females while males showed no dysregulation. Triglyceride concentrations were also found to be significantly elevated in female offspring exposed to Dex in utero, which may contribute to lipid metabolism activation. This study is the first to conduct an untargeted metabolic profile of liver from GC exposed offspring. Corroborating metabolic, gene expression and lipid profiling results demonstrates significant sex-specific lipid metabolic differences underlying the programming of hepatic metabolism.
C1 [Murray, Alyssa; Tharmalingam, Sujeenthar; Phong Nguyen; Tai, T. C.] Laurentian Univ, Northern Ontario Sch Med, 935 Ramsey Lake Rd, Sudbury, ON P3E 2C6, Canada.
   [Murray, Alyssa; Tharmalingam, Sujeenthar; Phong Nguyen; Tai, T. C.] Laurentian Univ, Dept Biol, Sudbury, ON P3E 2C6, Canada.
   [Tharmalingam, Sujeenthar; Tai, T. C.] Laurentian Univ, Dept Chem & Biochem, Sudbury, ON P3E 2C6, Canada.
   [Tharmalingam, Sujeenthar; Tai, T. C.] Laurentian Univ, Biomol Sci Program, Sudbury, ON P3E 2C6, Canada.
C3 NOSM University; Laurentian University; Laurentian University;
   Laurentian University; Laurentian University
RP Tai, TC (corresponding author), Laurentian Univ, Northern Ontario Sch Med, 935 Ramsey Lake Rd, Sudbury, ON P3E 2C6, Canada.; Tai, TC (corresponding author), Laurentian Univ, Dept Biol, Sudbury, ON P3E 2C6, Canada.; Tai, TC (corresponding author), Laurentian Univ, Dept Chem & Biochem, Sudbury, ON P3E 2C6, Canada.; Tai, TC (corresponding author), Laurentian Univ, Biomol Sci Program, Sudbury, ON P3E 2C6, Canada.
EM tc.tai@nosm.ca
RI Nguyen, Phong H/HHN-2723-2022
FU NOSMFA Research Development Fund
FX This research was funded by the NOSMFA Research Development Fund.
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NR 59
TC 5
Z9 7
U1 0
U2 20
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD OCT 13
PY 2021
VL 11
IS 1
AR 20342
DI 10.1038/s41598-021-99598-x
PG 12
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA WG5KC
UT WOS:000707032500100
PM 34645877
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Zegers, ES
   Meursing, BTJ
   Zegers, EB
   Ophuis, AJMO
AF Zegers, E. S.
   Meursing, B. T. J.
   Zegers, E. B.
   Ophuis, A. J. M. Oude
TI Coronary tortuosity: a long and winding road
SO NETHERLANDS HEART JOURNAL
LA English
DT Article
DE coronary tortuosity; angina pectoris; exercise test
ID ARTERIAL-WALL SHEAR; CAROTID-ARTERY; ANGINA-PECTORIS; SYNDROME-X;
   ATHEROSCLEROSIS; FLOW; VARIABILITY; BIFURCATION; MECHANISMS; GEOMETRY
AB Coronary tortuosity is a phenomenon often encountered by cardiologists performing coronary angiography. The aetiology and clinical importance of coronary tortuosity are stiff unclear. Coronary tortuosity without fixed atherosclerotic stenosis in patients with angina pectoris and an abnormal exercise stress test has never been described in the literature.
   This article describes three cases of patients with anginal complaints, an abnormal exercise stress test and coronary angiography without the presence of a fixed atherosclerotic lesion.
   It is hypothesised that coronary tortuosity leads to flow alteration resultiiig in a reduction in coronary pressure distal to the tortuous segment of the coronary artery, subsequently leading to ischaemia. Future studies will be necessary to elucidate the actual mechanism of coronary tortuosity and its clinical significance.
C1 [Meursing, B. T. J.; Ophuis, A. J. M. Oude] Canisius Wilhelmina Hosp, Dept Cardiol, NL-6500 GS Nijmegen, Netherlands.
   [Zegers, E. S.] Radboud Univ Nijmegen, Ctr Med, Dept Cardiol, NL-6525 ED Nijmegen, Netherlands.
   [Zegers, E. B.] Minist Transport Publ Works & Water Management, Nijmegen, Netherlands.
C3 Canisius-Wilhelmina Hospital; Radboud University Nijmegen
RP Ophuis, AJMO (corresponding author), Canisius Wilhelmina Hosp, Dept Cardiol, POB 9015, NL-6500 GS Nijmegen, Netherlands.
EM ton@oude.ophuis.net
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NR 30
TC 78
Z9 90
U1 0
U2 6
PU BOHN STAFLEU VAN LOGHUM BV
PI HOUTEN
PA POSTBUS 246, 3990 GA HOUTEN, NETHERLANDS
SN 1568-5888
EI 1876-6250
J9 NETH HEART J
JI Neth. Heart J.
PD MAY
PY 2007
VL 15
IS 5
BP 191
EP 195
DI 10.1007/BF03085979
PG 5
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 281UN
UT WOS:000254524500005
PM 17612682
OA Green Published
DA 2025-06-11
ER

PT J
AU Branchi, I
   Poggini, S
   Capuron, L
   Benedetti, F
   Poletti, S
   Tamouza, R
   Drexhage, HA
   Penninx, BWJH
   Pariante, CM
   Leboyer, M
AF Branchi, Igor
   Poggini, Silvia
   Capuron, Lucile
   Benedetti, Francesco
   Poletti, Sara
   Tamouza, Ryad
   Drexhage, Hemmo A.
   Penninx, Brenda W. J. H.
   Pariante, Carmine M.
   Leboyer, Marion
CA European Coll Neuropsychopharmacol
TI Brain-immune crosstalk in the treatment of major depressive disorder
SO EUROPEAN NEUROPSYCHOPHARMACOLOGY
LA English
DT Article
DE Inflammation; Antidepressants; Brain-body; Metabolism; Immunopsychiatry;
   Neural plasticity
ID C-REACTIVE PROTEIN; TUMOR-NECROSIS-FACTOR; ADJUNCTIVE CELECOXIB
   TREATMENT; POLYUNSATURATED FATTY-ACIDS; REGULATORY T-CELLS; INDOLEAMINE
   2,3-DIOXYGENASE; METABOLIC SYNDROME; INTERFERON-ALPHA; TREATMENT
   RESPONSE; DOUBLE-BLIND
AB A growing number of studies are pointing out the need for a conceptual shift from a brain centered to a body-inclusive approach in mental health research. In this perspective, the link between the immune and the nervous system, which are deeply interconnected and continuously interacting, is one of the most important novel theoretical framework to investigate the biological bases of major depressive disorder and, more in general, mental illness. Indeed, depressed patients show high levels of inflammatory markers, administration of pro-inflammatory drugs triggers a depressive symptomatology and antidepressant efficacy is reduced by excessive immune system activation. A number of molecular and cellular mechanisms have been hypothesized to act as a link between the immune and brain function, thus representing potential pharmacologically targetable processes for the development of novel and effective therapeutic strategies. These include the modulation of the kynurenine pathway, the crosstalk between metabolic and inflammatory processes, the imbalance in acquired immune responses, in particular T cell responses, and the interplay between neural plasticity and immune system activation. In the personalized medicine approach, the assessment and regulation of these processes have the potential to lead, respectively, to novel diagnostic approaches for the prediction of treatment outcome according to the patient's immunological profile, and to improved efficacy of antidepressant compounds through immune modulation. (c) 2020 Elsevier B.V. and ECNP. All rights reserved.
C1 [Branchi, Igor; Poggini, Silvia] Ist Super Sanita, Ctr Behav Sci & Mental Hlth, Viale Regina Elena 299, I-00161 Rome, Italy.
   [Capuron, Lucile] Univ Bordeaux, NutriNeuro, Bordeaux INP, INRAE,UMR 1286, Bordeaux, France.
   [Benedetti, Francesco; Poletti, Sara] IRCCS San Raffaele Sci Inst, Div Neurosci, Psychiat & Clin Psychobiol Unit, Milan, Italy.
   [Benedetti, Francesco; Poletti, Sara] Univ Vita Salute San Raffaele, Milan, Italy.
   [Tamouza, Ryad] Univ Paris Est Creteil, Hop Henri Mondor, AP HP,Fdn FondaMental,INSERM U955,IMRB, Lab Neuropsychiat Translat,Dept Med Univ Psychiat, F-94010 Creteil, France.
   [Drexhage, Hemmo A.] Univ Med Ctr Rotterdam, Dept Immunol, ErasmusMC, Rotterdam, Netherlands.
   [Penninx, Brenda W. J. H.] Vrije Univ Amsterdam, Dept Amsterdam Publ Hlth Res Inst, Dept Psychiat, Amsterdam UMC, Amsterdam, Netherlands.
   [Penninx, Brenda W. J. H.] Vrije Univ Amsterdam, Amsterdam Neurosci, Amsterdam, Netherlands.
   [Pariante, Carmine M.] Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Psychol Med, London, England.
C3 Istituto Superiore di Sanita (ISS); INRAE; Universite de Bordeaux;
   Institut National de la Sante et de la Recherche Medicale (Inserm);
   Vita-Salute San Raffaele University; IRCCS Ospedale San Raffaele;
   Vita-Salute San Raffaele University; Assistance Publique Hopitaux Paris
   (APHP); Universite Paris-Est-Creteil-Val-de-Marne (UPEC); Hopital
   Universitaire Henri-Mondor - APHP; Institut National de la Sante et de
   la Recherche Medicale (Inserm); Erasmus University Rotterdam; Erasmus
   MC; University of Amsterdam; Vrije Universiteit Amsterdam; Vrije
   Universiteit Amsterdam; University of London; King's College London
RP Branchi, I (corresponding author), Ist Super Sanita, Ctr Behav Sci & Mental Hlth, Viale Regina Elena 299, I-00161 Rome, Italy.
EM igor.branchi@iss.it
RI Tamouza, Ryad/AGQ-6644-2022; Poletti, Sara/U-3560-2017; Penninx,
   Brenda/S-7627-2017; Leboyer, Marion/AAW-3648-2021; Benedetti,
   Francesco/A-4124-2015; Poggini, Silvia/H-9286-2018; Branchi,
   Igor/N-9897-2017; Pariante, Carmine Maria/B-1297-2011
OI Benedetti, Francesco/0000-0003-4949-856X; Capuron,
   Lucile/0000-0002-2060-5918; Poggini, Silvia/0000-0002-3711-3725;
   Branchi, Igor/0000-0003-4484-3598; Pariante, Carmine
   Maria/0000-0002-9132-5091
FU MRC [MR/N029488/1, G108/603] Funding Source: UKRI
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NR 242
TC 47
Z9 48
U1 1
U2 10
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0924-977X
EI 1873-7862
J9 EUR NEUROPSYCHOPHARM
JI Eur. Neuropsychopharmacol.
PD APR
PY 2021
VL 45
BP 89
EP 107
DI 10.1016/j.euroneuro.2020.11.016
EA APR 2021
PG 19
WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA RN8EB
UT WOS:000640583200010
PM 33386229
OA Green Published
DA 2025-06-11
ER

PT J
AU Bergman, BP
   Mackay, DF
   Pell, JP
AF Bergman, B. P.
   Mackay, D. F.
   Pell, J. P.
TI Peripheral arterial disease in Scottish military veterans: a
   retrospective cohort study of 57 000 veterans and 173 000 matched
   non-veterans
SO JOURNAL OF PUBLIC HEALTH
LA English
DT Article
DE military veterans; peripheral arterial disease; retrospective cohort
   studies; risk factors; tobacco smoking
ID UK ARMED-FORCES; INTERMITTENT CLAUDICATION; SMOKING PREVALENCE;
   METABOLIC SYNDROME; SECONDHAND SMOKE; MENTAL-HEALTH; RISK-FACTORS;
   ASSOCIATION; YOUNG; EPIDEMIOLOGY
AB Background While traumatic limb loss in military personnel is widely known, the threat posed by peripheral arterial disease (PAD) in those who have served is less well recognized. The aim of our study was to examine the risk of PAD in a Scotland-wide cohort of veterans who served between 1960 and 2012.
   Methods Retrospective 30-year cohort study of 56 205 veterans born 1945-85, and 172 741 non-veterans, matched for age, sex and area of residence, using Cox proportional hazard models to examine the association between veteran status, birth cohort, length of service and risk of PAD leading to hospitalization or death.
   Results Overall, veterans were at increased risk of PAD compared with non-veterans, unadjusted hazard ratio (HR) = 1.46, 95% confidence intervals (CI): 1.33-1.60, P < 0.001. The highest risk was in veterans born between 1950 and 1954, HR = 1.76, 95% CI: 1.50-2.07, P < 0.001, and in those with the shortest service (early service leavers), HR = 1.84, 95% CI: 1.49-2.27, P < 0.001.
   Conclusions The findings provide evidence for a hidden burden of life- and limb-threatening PAD in older veterans and are consistent with the higher rates of military smoking which have been reported previously. The study emphasizes the need for vascular preventive measures in this group.
C1 [Bergman, B. P.; Mackay, D. F.; Pell, J. P.] Univ Glasgow, Inst Hlth & Wellbeing, Glasgow G12 8RZ, Lanark, Scotland.
C3 University of Glasgow
RP Bergman, BP (corresponding author), Inst Hlth & Wellbeing Publ Hlth & Hlth Policy, 1 Lilybank Gardens, Glasgow G12 8RZ, Lanark, Scotland.
EM Beverly.bergman@glasgow.ac.uk
OI Pell, Jill/0000-0002-8898-7035
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NR 35
TC 5
Z9 5
U1 0
U2 4
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1741-3842
EI 1741-3850
J9 J PUBLIC HEALTH-UK
JI J. Public Health
PD MAR
PY 2019
VL 41
IS 1
BP E9
EP E15
DI 10.1093/pubmed/fdy046
PG 7
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA HY1YC
UT WOS:000467912400004
PM 29534220
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Lee, D
   Shin, Y
   Jang, J
   Park, Y
   Ahn, J
   Jeong, S
   Shin, SS
   Yoon, M
AF Lee, Dongju
   Shin, Yujin
   Jang, Joonseong
   Park, Yonghyun
   Ahn, Jiwon
   Jeong, Sunhyo
   Shin, Soon Shik
   Yoon, Michung
TI The herbal extract ALS-L1023 from Melissa officinalis alleviates
   visceral obesity and insulin resistance in obese female C57BL/6J mice
SO JOURNAL OF ETHNOPHARMACOLOGY
LA English
DT Article
DE Female obesity; Glucose tolerance; Insulin resistance; Melissa
   officinalis; Lemon balm; Pancreatic dysfunction
ID HIGH-FAT DIET; ADIPOSE-TISSUE MASS; BETA-CELL APOPTOSIS; MOUSE MODEL;
   ADIPOCYTE HYPERTROPHY; PANCREATIC STEATOSIS; METABOLIC SYNDROME; LIVER;
   ADIPOGENESIS; ANGIOGENESIS
AB Ethnopharmacological relevance: Melissa officinalis L. (Labiatae; lemon balm) has traditionally been used as a medicinal herb to treat stress, anxiety, and insomnia. Current reports suggest that not only chronic stress stimulates angiogenesis, but angiogenesis also regulates adipogenesis and obesity. Because the herbal extract ALS-L1023 from Melissa officinalis inhibits angiogenesis, we hypothesized that ALS-L1023 could suppress visceral obesity and insulin resistance in obese female C57BL/6J mice, a mouse model of obese premenopausal women.
   Materials and methods: The mice were grouped and fed for 16 weeks as follows: 1) low-fat diet (LFD), 2) high-fat diet (HFD), or 3) HFD supplemented with 0.4 or 0.8% ALS-L1023. Variables and determinants of visceral obesity, insulin resistance, and pancreatic dysfunction were then assessed via blood analysis, histology, immunohistochemistry, and real-time polymerase chain reaction.
   Results: ALS-L1023 decreased weight gain, visceral adipocyte size, and serum lipid levels in HFD-fed obese mice. ALS-L1023 also normalized hyperglycemia and hyperinsulinemia and concomitantly reduced blood glucose levels during oral glucose tolerance tests. The pancreatic islet size and insulin-positive beta-cell area were significantly reduced in ALS-L1023-treated mice compared with untreated obese controls, reaching a level similar to that of LFD-fed lean mice. ALS-L1023 suppressed pancreatic lipid accumulation, infiltration of inflammatory cells, and collagen levels. ALS-L1023 treatment altered the pancreatic expression of genes involved in steatosis, inflammation, and fibrosis.
   Conclusions: Our findings indicate that the herbal extract ALS-L1023 from Melissa officinalis not only inhibits visceral obesity, but also attenuates the increased fasting blood glucose, impaired glucose tolerance, and pancreatic dysfunction seen in female obese mice. These results suggest that ALS-L1023 may be effective in the prevention of visceral obesity and insulin resistance in obese premenopausal women.
C1 [Lee, Dongju; Shin, Yujin; Jang, Joonseong; Park, Yonghyun; Jeong, Sunhyo; Yoon, Michung] Mokwon Univ, Dept Biomed Engn, Daejeon 35349, South Korea.
   [Ahn, Jiwon] Korea Res Inst Biosci & Biotechnol, Genome Res Ctr, Daejeon 34141, South Korea.
   [Shin, Soon Shik] Dong Eui Univ, Coll Oriental Med, Dept Formula Sci, Busan 47340, South Korea.
C3 Mokwon University; Korea Research Institute of Bioscience &
   Biotechnology (KRIBB); Dong-Eui University
RP Yoon, M (corresponding author), Mokwon Univ, Dept Biomed Engn, Daejeon 35349, South Korea.; Shin, SS (corresponding author), Dong Eui Univ, Coll Oriental Med, Dept Formula Sci, Busan 47340, South Korea.
EM dlehdwn100@naver.com; ujin2821@naver.com; jeseell21@naver.com;
   pyh1237026@naver.com; jiwon@kribb.re.kr; jsh0227@mokwon.ac.kr;
   ssshin@deu.ac.kr; yoon60@mokwon.ac.kr
FU National Research Foundation of Korea (NRF) by Korea government (MSIP)
   [2018R1D1A1B07042585]; Korea Health Industry Development Institute
   (KHIDI) by Korea government (MOHW) [HI16C0753]
FX This work was supported by the National Research Foundation of Korea
   (NRF) grant by the Korea government (MSIP) (No. 2018R1D1A1B07042585) and
   the Korea Health Industry Development Institute (KHIDI) grant by the
   Korea government (MOHW) (No. HI16C0753).
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NR 43
TC 17
Z9 17
U1 1
U2 18
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0378-8741
EI 1872-7573
J9 J ETHNOPHARMACOL
JI J. Ethnopharmacol.
PD MAY 10
PY 2020
VL 253
AR 112646
DI 10.1016/j.jep.2020.112646
PG 9
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA KZ9RX
UT WOS:000523597600023
PM 32027997
DA 2025-06-11
ER

PT J
AU Petrovics, P
   Nagy, A
   Sandor, B
   Palfi, A
   Szekeres, Z
   Toth, K
   Szabados, E
AF Petrovics, Peter
   Nagy, Alexandra
   Sandor, Barbara
   Palfi, Anita
   Szekeres, Zsolt
   Toth, Kalman
   Szabados, Eszter
TI Examination of Self-Esteem, Body Image, Eating Attitudes and
   Cardiorespiratory Performance in Adolescents
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Article
DE adolescent; self-esteem; body image; eating attitudes; cardiorespiratory
   performance
ID QUALITY-OF-LIFE; SAMPLE-SIZE CALCULATIONS; PHYSICAL-ACTIVITY; GENDER
   DIFFERENCES; METABOLIC SYNDROME; CHILDHOOD OBESITY; WEIGHT-GAIN;
   BEHAVIORS; FITNESS; HEALTH
AB Self-esteem, body image and eating attitudes are important characteristics regarding adolescent mental health. In our present work, we aimed to investigate these psychological items in adolescent boys and girls examining gender differences and correlations with the BMI-for-age and cardiorespiratory performance. 374 students (209 girls with an average age of 16.4 +/- 1.08 years, and 165 boys with an average age of 16.5 +/- 1.03 years) underwent investigation using the Rosenberg self-esteem scale, EAT-26 and BAT questionnaires. The BMI-for-age was calculated with BMI growth charts and the cardiorespiratory performance was measured with the 20 m shuttle run test. Our results showed that adolescent girls scored lower self-esteem and higher values for BAT and each scale of eating behaviors, such as uncontrolled eating, cognitive restraints and emotional eating compared to boys despite the fact, that obesity and overweight were more common among boys. No significant correlation was found between BMI and psychological test results in either boys or girls, however, subjective body shape and gender predicted self-esteem and BAT scores and the cognitive restraints in the eating attitudes. Uncontrolled and emotional eating were primarily influenced by gender, in which BMI played only a weaker role. Cardiorespiratory performance was positively associated with self-esteem and body image among boys, and it had a negative correlation regarding BMI in both genders.
C1 [Petrovics, Peter] Univ Pecs, Inst Phys Educ & Sport Sci, Fac Sci, H-7624 Pecs, Hungary.
   [Nagy, Alexandra] State Hosp Cardiol, H-8230 Balatonfured, Hungary.
   [Sandor, Barbara; Palfi, Anita; Szekeres, Zsolt; Szabados, Eszter] Univ Pecs, Sch Med, Dept Med 1, Div Prevent Cardiol & Rehabil, H-7623 Pecs, Hungary.
   [Toth, Kalman] Univ Pecs, Med Sch, Dept Med 1, Div Cardiol, H-7624 Pecs, Hungary.
C3 University of Pecs; University of Pecs; University of Pecs
RP Szabados, E (corresponding author), Univ Pecs, Sch Med, Dept Med 1, Div Prevent Cardiol & Rehabil, H-7623 Pecs, Hungary.
EM petropet@gamma.ttk.pte.hu; nagy.alexandra@szivkorhaz.hu;
   sandor.barbara@pte.hu; palfi.anita@pte.hu; szekeres.zsolt@pte.hu;
   toth.kalman@pte.hu; szabados.eszter@pte.hu
RI Frățilă, Alexandra Mihaela/NES-7065-2025
OI Petrovics, Peter/0000-0001-5143-5790; Sandor,
   Barbara/0000-0002-7028-4227; Toth, Kalman/0000-0002-0114-5231
FU University of Pecs, Medical School, Pecs, Hungary
   [EFOP-3.6.1-16-2016-00004]
FX FundingThe study was supported by EFOP-3.6.1-16-2016-00004 project of
   the University of Pecs, Medical School, Pecs, Hungary. The funder had no
   role in study design, data collection and analysis, decision to publish,
   or preparation of the manuscript.
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NR 78
TC 2
Z9 5
U1 3
U2 20
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD DEC
PY 2021
VL 18
IS 24
AR 13172
DI 10.3390/ijerph182413172
PG 14
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA YA8NI
UT WOS:000738582800001
PM 34948781
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Zhang, YW
   Wang, XD
   Song, YH
   Peng, RQ
   Tang, T
   Li, MD
   Yu, ZZ
   Ji, Y
   Niu, JP
AF Zhang, Yiwen
   Wang, Xiao-Dan
   Song, Yehua
   Peng, Ruiqiang
   Tang, Ting
   Li, Miaoduan
   Yu, Zhenzhen
   Ji, Yong
   Niu, Jianping
TI Epidemiology of Frequent/Urgent Urination in Older Adults in China: A
   Multicenter, Cross-Sectional Study
SO FRONTIERS IN PUBLIC HEALTH
LA English
DT Article
DE frequent urination; urgent urination; prevalence; risk factors;
   epidemiological survey
ID STANDARDIZATION SUB-COMMITTEE; REPORTED URINARY-INCONTINENCE; OVERACTIVE
   BLADDER; RISK-FACTORS; METABOLIC SYNDROME; TRACT FUNCTION; PREVALENCE;
   WOMEN; POPULATION; SYMPTOMS
AB Background: Frequent/urgent urination is an event of multifactorial origin where involuntary leakage of urine occurs. Epidemiological study of this condition is of high importance due to its negative impact on the psychological, physical, and social well-being of the victims.
   Objective: This cross-sectional study aimed to investigate the prevalence of frequent/urgent urination in older adults in China.
   Method: In this study, a face-to-face questionnaire survey was conducted between April 2019 and August 2019 among 4,796 older adult populations in the communities of Tianjin jizhou and Xiamen jimei of China. Descriptive analysis, univariate regression, and all statistics were conducted in IBM SPSS v22. The count data were analyzed by chi-square test. P < 0.05 was considered statistically significant.
   Results: In the total investigated population, the prevalence of frequent or urgent urination was found in 1,164 patients (24.3%) where 31.7% (664/2,097) were male patients and 18.7% (500/2,699) were female patients, having a male-to-female ratio of 1.7:1. The prevalence was higher in the 70- to 84-year-old group (men: 33.3-34.8%, women 19.5-20.8%), whereas it was relatively low in the 65- to 69-year-old group and in older adults over 85 years of age (men 28.8, 30.3%, women 16.7, 18.5%, respectively). In terms of the course of the disease, among the population aged 65 years and above, 17.3% men and 9.9% women had frequent urination/urgency lasting for 1-4 years; 5-9 years in about 4.5% population (7.4% men and 4.2% women); 10-19 years in 4.9% men and 2.3% women; and more than 20 years duration in 1.6% men and 1.9% women. On the severity scale, mild frequent/urgent urination was observed in 24.6% of men and 15.4% women of Chinese older adults. Moderate cases were observed in 6.3% of men and 2.9% of women, whereas severe cases were found in 0.8% men and 0.2% women. Benign prostatic hyperplasia (BPH)/hypertrophy was the main risk factor for frequent/urgent urination in Chinese older adult men (P < 0.001). Obesity, hypertension, diabetes, heart disease, anxiety, depression, constipation, and brain injury were the other risk factors for frequent/urgent urination in Chinese older adult men and women. The results of this survey showed that smoking or drinking habits did not increase the prevalence of frequent/urgent urination in Chinese older adults.
   Conclusions: According to the results of this survey, the prevalence rate of frequent/urgent urination is high, and the course of the disease is long in Chinese older adults. BPH and depression, anxiety, and age-related chronic diseases increase the risk of frequent/urgent urination in Chinese older adults.
C1 [Zhang, Yiwen; Song, Yehua; Peng, Ruiqiang; Tang, Ting; Li, Miaoduan; Yu, Zhenzhen; Niu, Jianping] Xiamen Med Coll, Affiliated Hosp 2, Dept Neurol, Xiamen, Peoples R China.
   [Wang, Xiao-Dan; Ji, Yong] Tianjin Huanhu Hosp, Tianjin Dementia Inst, Dept Necrol, Tianjin Key Lab Cerebrovasc & Neurodegenerat Dis, Tianjin, Peoples R China.
   [Ji, Yong] Capital Med Univ, Beijing Tiantan Hosp, China Natl Clin Res Ctr Neurol Dis, Dept Neurol, Beijing, Peoples R China.
C3 Xiamen Medical College; Capital Medical University
RP Niu, JP (corresponding author), Xiamen Med Coll, Affiliated Hosp 2, Dept Neurol, Xiamen, Peoples R China.; Ji, Y (corresponding author), Tianjin Huanhu Hosp, Tianjin Dementia Inst, Dept Necrol, Tianjin Key Lab Cerebrovasc & Neurodegenerat Dis, Tianjin, Peoples R China.; Ji, Y (corresponding author), Capital Med Univ, Beijing Tiantan Hosp, China Natl Clin Res Ctr Neurol Dis, Dept Neurol, Beijing, Peoples R China.
EM jiyongusa@126.com; 549872685@qq.com
RI Zhang, Yiwen/GWM-7219-2022
FU National Key Research and Development Program of China [2016YFC1306305];
   Scientific Research Project of Tianjin Nursing Association
   [tjhlky2020YB05]
FX This work was supported by the National Key Research and Development
   Program of China (grant number 2016YFC1306305) and the Scientific
   Research Project of Tianjin Nursing Association (grant number
   tjhlky2020YB05).
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NR 45
TC 7
Z9 7
U1 0
U2 10
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 2296-2565
J9 FRONT PUBLIC HEALTH
JI Front. Public Health
PD SEP 7
PY 2021
VL 9
AR 669070
DI 10.3389/fpubh.2021.669070
PG 8
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA US2UE
UT WOS:000697289900001
PM 34557463
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Ketter, TA
   Haupt, DW
AF Ketter, Terence A.
   Haupt, Dan W.
TI Perceptions of weight gain and bipolar pharmacotherapy: results of a
   2005 survey of physicians in clinical practice
SO CURRENT MEDICAL RESEARCH AND OPINION
LA English
DT Article
DE atypical antipsychotics; bipolar disorder; metabolic syndrome; mood
   stabilizers; obesity; weight gain
ID WEEKLY SYMPTOMATIC STATUS; DOUBLE-BLIND; MAINTENANCE TREATMENT;
   NATURAL-HISTORY; BODY-WEIGHT; LITHIUM; MONOTHERAPY; DISORDER; OBESITY;
   SAFETY
AB Objective: To assess the perceptions of clinicians in the psychiatric community about pharmacotherapy and its impact on weight gain and adverse metabolic effects in patients with bipolar disorder.
   Methods: In November 2005, self-administered questionnaires were sent to 7000 psychiatrists who treat bipolar disorder in their clinical practice. An additional mailing of these questionnaires was sent in January 2006 to a different group of 7000 psychiatrists who treat bipolar disorder in their clinical practice. The first 298 completed surveys were analyzed.
   Results: Almost half of the respondents ( 48%) were psychiatrists in individual private practice and 32% were in community mental health centers. About two-thirds of respondents reported that 30 - 60% of their bipolar patients were overweight. Thirty-eight percent of respondents reported metabolic syndrome present in 20 - 40% of their patients. Almost all respondents ( 96%) reported a 20 lb increase in patients' weight as a troublesome potential adverse event associated with the use of some agents. After initiating a new medication, more than 80% of respondents monitored their patients' weight, fasting plasma glucose level, and fasting lipid profile at regular intervals. However, 80% did not monitor waist circumference. Overall, respondents viewed several agents ( aripiprazole, ziprasidone, carbamazepine, and lamotrigine) as not ( or minimally) problematic in terms of weight gain and adverse metabolic concerns. Clozapine and olanzapine were viewed as highly problematic due to their propensity to induce weight gain and negatively influence lipid and glucose metabolism. Other agents considered to be minimally to moderately problematic in terms of weight gain and metabolic issues were quetiapine, risperidone, lithium, and valproate. Respondents reported that the profile of a bipolar agent in terms of weight gain and adverse metabolic effects was an important consideration in the management of bipolar disorder.
   Conclusion: Although the study is limited by a low response rate and self-selection of respondents, clinicians who did respond were concerned about the risks of weight gain and metabolic disturbances in their patients treated with bipolar agents. For most parameters, such concerns were being integrated into clinical care. However, it appears that there is a need to increase clinicians' appreciation of the importance of abdominal obesity and the need to monitor waist circumference. A growing recognition of the differences in weight-gain potential and adverse metabolic effects among agents appears to have had a definite impact on prescribing patterns in the management of bipolar disorder.
C1 Stanford Univ, Sch Med, Dept Psychiat & Behav Sci, Stanford, CA 94305 USA.
   Washington Univ, Sch Med, St Louis, MO USA.
C3 Stanford University; Washington University (WUSTL)
RP Ketter, TA (corresponding author), Stanford Univ, Sch Med, Dept Psychiat & Behav Sci, Stanford, CA 94305 USA.
EM tketter@stanford.edu
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NR 38
TC 33
Z9 36
U1 0
U2 3
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0300-7995
EI 1473-4877
J9 CURR MED RES OPIN
JI Curr. Med. Res. Opin.
PD DEC
PY 2006
VL 22
IS 12
BP 2345
EP 2353
DI 10.1185/030079906X148616
PG 9
WC Medicine, General & Internal; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Research & Experimental Medicine
GA 122PM
UT WOS:000243238900004
PM 17257449
DA 2025-06-11
ER

PT J
AU Figorilli, M
   Velluzzi, F
   Redolfi, S
AF Figorilli, Michela
   Velluzzi, Fernanda
   Redolfi, Stefania
TI Obesity and sleep disorders: A bidirectional relationship
SO NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
LA English
DT Review
ID RESTLESS LEGS SYNDROME; GENOME-WIDE ASSOCIATION; HYPOVENTILATION
   SYNDROME; UPPER AIRWAY; CARDIOMETABOLIC HEALTH; DIAGNOSTIC-CRITERIA;
   AMERICAN ACADEMY; APNEA MECHANISMS; DURATION; RISK
AB Aims: Obesity and sleep disorders are highly prevalent conditions with profound implications for public health. Emerging evidence highlights a bidirectional relationship between these two conditions, with each exacerbating the other in a complex interplay of behavioral, physiological, and hormonal mechanisms. Sleep deprivation and poor sleep quality contribute to energy imbalance through dysregulation of appetite hormones (e.g., leptin and ghrelin), increased caloric intake, and reduced physical activity. Conversely, sleep disorders such as obstructive sleep apnea syndrome (OSAS), insomnia, and restless leg syndrome (RLS) are significantly more common in individuals with obesity. Data synthesis: This review explores the pathophysiological mechanisms underlying this relationship, including the roles of inflammation, autonomic dysregulation, and neuroendocrine pathways. Sleep loss exacerbates metabolic syndrome components, including insulin resistance and dyslipidemia, further perpetuating weight gain. Similarly, obesity-induced sleep disorders lead to pro-inflammatory states, vascular dysfunction, and sympathetic overactivation, compounding cardiometabolic risks. Specific conditions like OSA and RLS are examined as models of this interdependence, emphasizing their shared pathways and clinical implications. Conclusions: The bidirectional link between obesity and sleep disorders underscores the importance of integrating sleep assessment and management into obesity treatment strategies. Addressing this relationship could mitigate the progression of cardiometabolic comorbidities and improve overall health outcomes. Moreover, the intertwined dynamics between obesity, sleep disorders, and mental health-mediated by inflammatory pathways, hormonal dysregulation, and neurobehavioral factors-highlight the critical need for integrated treatment approaches targeting physical, psychological, and sleep-related dimensions to enhance health and quality of life.
C1 [Figorilli, Michela; Redolfi, Stefania] Univ Cagliari, Sleep Disorder Res Ctr, Dept Med Sci & Publ Hlth, Cagliari, Italy.
   [Velluzzi, Fernanda] Univ Cagliari, Dept Med Sci & Publ Hlth, Obes Unit, Cagliari, Italy.
C3 University of Cagliari; University of Cagliari
RP Redolfi, S (corresponding author), Univ Cagliari, Sleep Disorder Res Ctr, Dept Med Sci & Publ Hlth, Cagliari, Italy.
EM stefania.redolfi@unica.it
RI Figorilli, Michela/AAB-8693-2021
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NR 101
TC 1
Z9 1
U1 1
U2 1
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 0939-4753
EI 1590-3729
J9 NUTR METAB CARDIOVAS
JI Nutr. Metab. Carbiovasc. Dis.
PD JUN
PY 2025
VL 35
IS 6
AR 104014
DI 10.1016/j.numecd.2025.104014
PG 8
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism; Nutrition
   & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism;
   Nutrition & Dietetics
GA 2ES0T
UT WOS:001480877600001
PM 40180826
OA hybrid
DA 2025-06-11
ER

PT J
AU Fond, G
   Boyer, L
   Berna, F
   Godin, O
   Bulzacka, E
   Andrianarisoa, M
   Brunel, L
   Aouizerate, B
   Capdevielle, D
   Chereau, I
   Coulon, N
   D'Amato, T
   Dubertret, C
   Dubreucq, J
   Faget, C
   Leignier, S
   Lançon, C
   Mallet, J
   Misdrahi, D
   Passerieux, C
   Rey, R
   Schandrin, A
   Urbach, M
   Vidailhet, P
   Leboyer, M
   Schürhoff, F
   Llorca, PM
AF Fond, Guillaume
   Boyer, Laurent
   Berna, Fabrice
   Godin, Ophelia
   Bulzacka, Ewa
   Andrianarisoa, Meja
   Brunel, Lore
   Aouizerate, Bruno
   Capdevielle, Delphine
   Chereau, Isabelle
   Coulon, Nathalie
   D'Amato, Thierry
   Dubertret, Caroline
   Dubreucq, Julien
   Faget, Catherine
   Leignier, Sylvain
   Lancon, Christophe
   Mallet, Jasmina
   Misdrahi, David
   Passerieux, Christine
   Rey, Romain
   Schandrin, Aurelie
   Urbach, Mathieu
   Vidailhet, Pierre
   Leboyer, Marion
   Schurhoff, Franck
   Llorca, Pierre-Michel
CA FACE-SZ FondaMental Acad Ctr
TI Remission of depression in patients with schizophrenia and comorbid
   major depressive disorder: results from the FACE-SZ cohort
SO BRITISH JOURNAL OF PSYCHIATRY
LA English
DT Article
ID ALCOHOL-USE DISORDERS; METABOLIC SYNDROME; PERSECUTORY DELUSIONS;
   2ND-GENERATION ANTIPSYCHOTICS; CHILDHOOD TRAUMA; SELF-REPORT; PSYCHOSIS;
   SCALE; SYMPTOMS; VALIDITY
AB Background
   Major depressive disorder (MDD) is underdiagnosed and undertreated in schizophrenia, and has been strongly associated with impaired quality of life.
   Aims
   To determine the prevalence and associated factors of MDD and unremitted MDD in schizophrenia, to compare treated and non-treated MDD.
   Method
   Participants were included in the FondaMental Expert Centers for Schizophrenia and received a thorough clinical assessment. MDD was defined by a Calgary score 6. Non-remitted MDD was defined by current antidepressant treatment (unchanged for >8 weeks) and current Calgary score 6.
   Results
   613 patients were included and 175 (28.5%) were identified with current MDD. MDD has been significantly associated with respectively paranoid delusion (odds ratio 1.8; P = 0.01), avolition (odds ratio 1.8; P = 0.02), blunted affect (odds ratio 1.7; P = 0.04) and benzodiazepine consumption (odds ratio 1.8; P = 0.02). Antidepressants were associated with lower depressive symptoms score (5.4 v. 9.5; P < 0.0001); however, 44.1% of treated patients remained in non-remittance MDD. Nonremitters were found to have more paranoid delusion (odds ratio 2.3; P = 0.009) and more current alcohol misuse disorder (odds ratio 4.8; P = 0.04). No antidepressant class or specific antipsychotic were associated with higher or lower response to antidepressant treatment. MDD was associated with Metabolic syndrome (31.4 v. 20.2%; P = 0.006) but not with increased C-reactive protein.
   Conclusions
   Antidepressant administration is associated with lower depressive symptom level in patients with schizophrenia and MDD. Paranoid delusions and alcohol misuse disorder should be specifically explored and treated in cases of non-remission under treatment. MetS may play a role in MDD onset and/or maintenance in patients with schizophrenia. (C) The Royal College of Psychiatrists 2018.
C1 [Fond, Guillaume; Boyer, Laurent; Berna, Fabrice; Godin, Ophelia; Bulzacka, Ewa; Andrianarisoa, Meja; Brunel, Lore; Aouizerate, Bruno; Capdevielle, Delphine; Chereau, Isabelle; Coulon, Nathalie; D'Amato, Thierry; Dubertret, Caroline; Dubreucq, Julien; Faget, Catherine; Leignier, Sylvain; Lancon, Christophe; Mallet, Jasmina; Misdrahi, David; Passerieux, Christine; Rey, Romain; Schandrin, Aurelie; Urbach, Mathieu; Leboyer, Marion; Schurhoff, Franck; Llorca, Pierre-Michel] Fdn FondaMental, Creteil, France.
   [Fond, Guillaume; Boyer, Laurent; Faget, Catherine; Lancon, Christophe] Aix Marseille Univ, Fac Med, Ctr Etud & Rech Serv Sante & Qualite Vie, Marseille, France.
   [Berna, Fabrice; Vidailhet, Pierre] Univ Strasbourg, Hop Univ Strasbourg, Federat Med Translat Strasbourg, INSERM,U1114, Strasbourg, France.
   [Godin, Ophelia] Univ Paris 06, Inst Pierre Louis Epidemiol & Sante Publ, Sorbonne Univ, UMR S 1136,INSERM, Paris, France.
   [Bulzacka, Ewa; Andrianarisoa, Meja; Brunel, Lore; Schurhoff, Franck] Univ Paris Est Creteil, Hop Univ H Mondor, Pole Psychiat, INSERM,U955, Creteil, France.
   [Aouizerate, Bruno; Misdrahi, David] Univ Bordeaux, Ctr Hosp Charles Perrens, Bordeaux, France.
   [Aouizerate, Bruno] Univ Bordeaux, INRA, NutriNeuro, Bordeaux, France.
   [Capdevielle, Delphine; Schandrin, Aurelie] Univ Montpellier I, INSERM 1061, Serv Univ Psychiat Adulte, Hop Colombiere,CHRU Montpellier, Montpellier, France.
   [Chereau, Isabelle; Llorca, Pierre-Michel] Univ Auvergne, Fac Med, CMP B, CHU,EA 7280, Clermont Ferrand, France.
   [Coulon, Nathalie] Univ Paris Est Creteil, Hop Univ H Mondor, INSERM, U955,Pole Psychiat, Creteil, France.
   [D'Amato, Thierry; Rey, Romain] Univ Claude Bernard Lyon 1, Ctr Rech Neurosci Lyon, Ctr Hosp Le Vinatier, INSERM,U1028,CNRS,UMR5292,Equipe PSYR2, Lyon, France.
   [Dubertret, Caroline; Mallet, Jasmina] Louis Mourier Hosp, AP HP, Dept Psychiat, Colombes, France.
   [Dubertret, Caroline; Mallet, Jasmina] Univ Paris Diderot, Fac Med, Sorbonne Paris Cite, INSERM,U894, Paris, France.
   [Dubreucq, Julien; Leignier, Sylvain] CH Alpes Isere, Ctr Referent Rehabil Psychosociale, St Egreve, France.
   [Misdrahi, David] Univ Bordeaux, Inst Neurosci Cognit & Integrat Aquitaine, CNRS, UMR 5287, Bordeaux, France.
   [Passerieux, Christine; Urbach, Mathieu] Univ Versailles St Quentin en Yvelines, Ctr Hosp Versailles, Serv Psychiat & Addictol Adulte, EA HANDIReSP 4047,UFR Sci Sante Simone Veil, Versailles, France.
C3 Aix-Marseille Universite; CHU Strasbourg; Institut National de la Sante
   et de la Recherche Medicale (Inserm); Universite de Lorraine;
   Universites de Strasbourg Etablissements Associes; Universite de
   Strasbourg; Sorbonne Universite; Institut National de la Sante et de la
   Recherche Medicale (Inserm); Institut National de la Sante et de la
   Recherche Medicale (Inserm); Universite Paris-Est-Creteil-Val-de-Marne
   (UPEC); Assistance Publique Hopitaux Paris (APHP); Hopital Universitaire
   Henri-Mondor - APHP; Universite de Bordeaux; Universite de Bordeaux;
   INRAE; Universite de Montpellier; CHU de Montpellier; Institut National
   de la Sante et de la Recherche Medicale (Inserm); Universite Clermont
   Auvergne (UCA); CHU Clermont Ferrand; Institut National de la Sante et
   de la Recherche Medicale (Inserm); Assistance Publique Hopitaux Paris
   (APHP); Universite Paris-Est-Creteil-Val-de-Marne (UPEC); Hopital
   Universitaire Henri-Mondor - APHP; Centre National de la Recherche
   Scientifique (CNRS); Institut National de la Sante et de la Recherche
   Medicale (Inserm); Universite Claude Bernard Lyon 1; Universite Jean
   Monnet; CNRS - National Institute for Biology (INSB); Universite Paris
   Cite; Assistance Publique Hopitaux Paris (APHP); Hopital Universitaire
   Louis-Mourier - APHP; Universite Paris Cite; Institut National de la
   Sante et de la Recherche Medicale (Inserm); Centre National de la
   Recherche Scientifique (CNRS); CNRS - National Institute for Biology
   (INSB); Universite de Bordeaux; Universite Paris Saclay; Centre
   Hospitalier de Versailles
RP Fond, G (corresponding author), Aix Marseille Univ, Fac Med, EA Ctr Etud & Rech Serv Sante & Qualite Vie 3279, Sect Timone, 27 Blvd Jean Moulin, F-13005 Marseille, France.
EM guillaume.fond@ap-hm.fr
RI Schandrin, Aurélie/ISV-4608-2023; Capdevielle, Delphine/HTO-4229-2023;
   Mallet, Jasmina/GNP-7160-2022; Leboyer, Marion/AAW-3648-2021; COULON,
   Nathalie/HLW-3075-2023; Boyer, Laurent/E-5728-2016; Berna,
   Fabrice/J-2701-2019; TESSIER, Arnaud/A-4022-2017; FOND,
   Guillaume/D-7646-2011
OI TESSIER, Arnaud/0000-0001-5758-5693; Capdevielle,
   Delphine/0000-0002-7146-8554; LEBOYER, Marion/0000-0001-5473-3697;
   COULON, Nathalie/0000-0001-7765-1117; D'Amato,
   Thierry/0000-0001-8983-0315; Aouizerate, Bruno/0000-0002-7092-7747; REY,
   Romain/0000-0002-4603-3575; FOND, Guillaume/0000-0003-3249-2030;
   Misdrahi, David/0000-0003-1146-3206; dubreucq,
   julien/0000-0003-4079-4194
FU Assistance Publique des Hopitaux de Paris, Fondation FondaMental (RTRS
   Reseau Thematique de Recherche et de Soins Sante Mentale);
   Investissements d'Avenir programme [ANR-11-IDEX-0004-02,
   ANR-10-COHO-10-01]; Institut National de la Sante et de la Recherche
   Medicale
FX This work was funded by Assistance Publique des Hopitaux de Paris,
   Fondation FondaMental (RTRS Reseau Thematique de Recherche et de Soins
   Sante Mentale), by the Investissements d'Avenir programme managed by the
   ANR Agence Nationale de la Recherche (reference no. ANR-11-IDEX-0004-02
   and ANR-10-COHO-10-01) and by the Institut National de la Sante et de la
   Recherche Medicale.
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NR 52
TC 39
Z9 39
U1 0
U2 6
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1250
EI 1472-1465
J9 BRIT J PSYCHIAT
JI Br. J. Psychiatry
PD AUG
PY 2018
VL 213
IS 2
BP 464
EP 470
DI 10.1192/bjp.2018.87
PG 7
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA GN8WR
UT WOS:000439458700005
PM 29871707
OA Bronze
DA 2025-06-11
ER

PT J
AU Wang, DM
   Liu, L
   Yan, JQ
   Wu, WL
   Zhu, XY
   Wang, Y
AF Wang, Dongmei
   Liu, Ling
   Yan, Junqiang
   Wu, Wenlan
   Zhu, Xiaoying
   Wang, Yong
TI Cardiotrophin-1 (CT-1) Improves High Fat Diet-Induced Cognitive Deficits
   in Mice
SO NEUROCHEMICAL RESEARCH
LA English
DT Article
DE CT-1; High fat diet; Cognitive deficits; Insulin/IGF signaling;
   Neuroinflammation
ID NEURONAL INSULIN-RESISTANCE; TUMOR-NECROSIS-FACTOR; LONG-TERM
   DEPRESSION; ALZHEIMERS-DISEASE; GENE-TRANSFER; FOOD-INTAKE; IN-VIVO;
   SYNAPTIC PLASTICITY; INTRANASAL INSULIN; METABOLIC SYNDROME
AB Previous studies demonstrated that a high fat diet (HFD) results in a loss of working memory in mice correlated with neuroinflammatory changes as well as synaptodendritic abnormalities and brain insulin resistance. Cardiotrophin-1 (CT-1), a member of the gp130 cytokine family, has been shown to potentially play a critical role in obesity and the metabolic syndrome. Our recent studies have demonstrated that CT-1 attenuates cognitive impairment and glucose-uptake defects induced by amyloid-beta in mouse brain through inhibiting GSK-3 beta activity. In this study, we evaluated the effect of CT-1 on cognitive impairment induced by brain insulin resistance in mice fed a HFD, and explored its potential mechanism. CT-1 (1 mu g/day, intracerebroventricular injection) was given for 14 days to mice that were fed with either a HFD or normal diet for 18 weeks. After 20 weeks of treatment, our results showed that in the HFD group, CT-1 significantly improved learning and memory deficits and alleviated neuroinflammation demonstrated by decreasing brain levels of proinflammatory cytokine tumour necrosis factor-alpha and interleukin-1 beta, and increasing brain levels of anti-inflammatory cytokine IL-10. CT-1 significantly reduced body weight gain, restored normal levels of blood glucose, fatty acids and cholesterol. Furthermore, CT-1 significantly enhanced insulin/IGF signaling pathway as indicated by increasing the expression levels of insulin receptor substrate 1 (IRS-1) and the phosphorylation of Akt/GSK-3 beta, and reducing the phosphorylation of IRS-1 in the hippocampus compared to control. Moreover, CT-1 increased the level of the post-synaptic protein, PSD95, and drebrin, a dendritic spine-specific protein in the hippocampus. These results indicate a previously unrecognized potential of CT-1 in alleviating high-fat diet induced cognitive impairment.
C1 [Wang, Dongmei; Wu, Wenlan; Zhu, Xiaoying; Wang, Yong] Henan Univ Sci & Technol, Dept Pathogen Biol, Coll Med, Jianxi Dist 471003, Luoyang, Peoples R China.
   [Liu, Ling] Henan Univ Sci & Technol, Dept Pharm, Coll Med, Jianxi Dist 471003, Luoyang, Peoples R China.
   [Yan, Junqiang] Henan Univ Sci & Technol, Affiliated Hosp 1, Dept Neurol, Jianxi Dist 471003, Luoyang, Peoples R China.
C3 Henan University of Science & Technology; Henan University of Science &
   Technology; Henan University of Science & Technology
RP Wang, DM (corresponding author), Henan Univ Sci & Technol, Dept Pathogen Biol, Coll Med, Bldg 6, Jianxi Dist 471003, Luoyang, Peoples R China.
EM wdmzgadyx@163.com
RI Wu, Wenlan/L-9626-2019
FU National Natural Science Foundation of China [U1304806, U1304809];
   Scientific Research Fund of Henan University of Science and Technology
   [09001664]
FX The present work was supported by National Natural Science Foundation of
   China (U1304806 and U1304809) and the Scientific Research Fund of Henan
   University of Science and Technology (No. 09001664).
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NR 69
TC 10
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U1 0
U2 16
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0364-3190
EI 1573-6903
J9 NEUROCHEM RES
JI Neurochem. Res.
PD APR
PY 2015
VL 40
IS 4
BP 843
EP 853
DI 10.1007/s11064-015-1535-z
PG 11
WC Biochemistry & Molecular Biology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Neurosciences & Neurology
GA CE5HE
UT WOS:000351861100022
PM 25672823
DA 2025-06-11
ER

PT J
AU Grover, SA
   Lowensteyn, I
   Kaouache, M
   Marchand, S
   Coupal, L
   DeCarolis, E
   Zoccoli, J
   Defoy, I
AF Grover, SA
   Lowensteyn, I
   Kaouache, M
   Marchand, S
   Coupal, L
   DeCarolis, E
   Zoccoli, J
   Defoy, I
TI The prevalence of erectile dysfunction in the primary care setting -
   Importance of risk factors for diabetes and vascular disease
SO ARCHIVES OF INTERNAL MEDICINE
LA English
DT Article
ID CORONARY-HEART-DISEASE; INTERNATIONAL INDEX; COMORBID DEPRESSION;
   METABOLIC SYNDROME; IMPOTENCE; MEN; EPIDEMIOLOGY; OLDER
AB Background: The prevalence of erectile dysfunction (ED) and associated risk factors has been described in many clinical settings, but there is little information regarding men seen by primary care physicians. We sought to identify independent factors associated with ED in a primary care setting.
   Methods: We surveyed a cross-sectional sample of 3921 Canadian men, aged 40 to 88 years, seen by primary care physicians. Participants completed a full medical history, physical examination, and measurement of fasting blood glucose and lipid levels. We used the International index of Erectile Function to define ED as a score of less than 26 on the erectile function domain.
   Results: The overall prevalence of ED was 49.4%. The presence of cardiovascular disease (odds ratio [OR], 1.45; 95% confidence interval [CI], 1.16-1.81; P < .01) or diabetes (OR, 3.13; 95% CI, 2.35-4.16; P < .001) increased the probability of ED after adjustment for other confounders. Among those individuals without cardiovascular disease or diabetes, the calculated 10-year Framingham coronary risk (OR, 1.03 per 1% increase; 95% CI, 1.02-1.05; P < .001) and fasting blood glucose levels (OR, 1.14 per 18-mg/dL [1-mmol/L] increase; 95% CI, 1.04-1.24; P < .01) were independently associated with ED. Erectile dysfunction was also independently associated with undiagnosed hyperglycemia (OR, 1.46; 95% CI, 1.02=2.10; P = .04), impaired fasting glucose (OR, 1.26; 95% CI, 1.08-1.46; P = .004), and the metabolic syndrome (OR, 1.45; 95% CI, 1.24-1.69; P < .001).
   Conclusions: Cardiovascular disease, diabetes, future coronary risk, and increasing fasting glucose levels are independently associated with ED. It remains to be determined if ED precedes the development of these conditions.
C1 Montreal Gen Hosp, Div Clin Epidemiol, Montreal, PQ H3G 1A4, Canada.
   Montreal Gen Hosp, Ctr Anal Cost Effect Care, Montreal, PQ H3G 1A4, Canada.
   Montreal Gen Hosp, Div Gen Internal Med, Montreal, PQ H3G 1A4, Canada.
   McGill Univ, Dept Med, Montreal, PQ, Canada.
   McGill Univ, Dept Epidemiol & Biostat, Montreal, PQ, Canada.
   Pfizer Canada, Kirkland, PQ, Canada.
C3 McGill University; McGill University; McGill University; McGill
   University; McGill University; Pfizer; Pfizer Canada
RP Montreal Gen Hosp, Div Clin Epidemiol, 1650 Cedar Ave, Montreal, PQ H3G 1A4, Canada.
EM steven.grover@mcgill.ca
RI Kaouache, Mohammed/LKJ-8221-2024
OI Coupal, Louis/0000-0003-0828-9665
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NR 34
TC 203
Z9 213
U1 0
U2 8
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 0003-9926
EI 1538-3679
J9 ARCH INTERN MED
JI Arch. Intern. Med.
PD JAN 23
PY 2006
VL 166
IS 2
BP 213
EP 219
DI 10.1001/archinte.166.2.213
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 004RH
UT WOS:000234769400012
PM 16432091
DA 2025-06-11
ER

PT J
AU Boozalis, T
   Devaraj, S
   Okusaga, OO
AF Boozalis, Ted
   Devaraj, Sridevi
   Okusaga, Olaoluwa O.
TI Correlations between Body Mass Index, Plasma High-Sensitivity C-Reactive
   Protein and Lipids in Patients with Schizophrenia
SO PSYCHIATRIC QUARTERLY
LA English
DT Article
DE Schizophrenia; BMI; Hs-CRP; Plasma lipids; Overweight; Obese;
   Cardiovascular disease
ID METABOLIC SYNDROME; RISK-FACTORS; ANTIPSYCHOTIC TREATMENT; OBESITY;
   DISORDERS; MORTALITY; ASSOCIATIONS; INDIVIDUALS; ACTIVATION; DEPRESSION
AB High prevalence of obesity in individuals with schizophrenia, associated with metabolic syndrome, leads to high rate of premature deaths from cardiovascular disease (CVD) in this population. Body mass index (BMI) and C-reactive protein (CRP) are correlated in the general population but this relationship has not been fully elucidated in patients with schizophrenia. We aimed to evaluate the correlation between BMI and CRP while relating both variables to plasma lipids in patients with schizophrenia. BMI, fasting high sensitivity CRP (hs-CRP), cotinine, and lipids were measured in 106 patients with schizophrenia (diagnosis confirmed with MINI). Pearson's and partial correlations (adjusting for age, sex, race, education and cotinine) between BMI, hs-CRP and lipids were calculated. Based on BMI, the patients were divided into normal-weight vs. overweight/obese and t-tests and linear regression were done to compare hs-CRP and lipids in the 2 groups. BMI positively correlated with hs-CRP (r=0.29, p=0.004). BMI and hs-CRP negatively correlated with HDL in the total sample (r=-0.29, p=0.004; r=-0.37, p<0.001 respectively). Furthermore, hs-CRP negatively correlated with HDL in overweight/obese patients (r=-0.41, p=0.003), but not in normal-weight patients. hs-CRP and triglycerides were higher (1.62 +/- 0.09mg/L vs. 0.56 +/- 0.08mg/L, p<0.001; 121.77 +/- 8.96mg/dL vs. 91.23 +/- 6.52mg/dL, p=0.008 respectively) and HDL lower (39.55 +/- 1.48mg/dL vs. 50.68 +/- 2.24mg/dL, p<0.001) in overweight/obese patients. Being overweight/obese is associated with increased inflammation and dyslipidemia in patients with schizophrenia. Effective interventions to prevent weight gain in schizophrenia are urgently needed.
C1 [Boozalis, Ted; Okusaga, Olaoluwa O.] Baylor Coll Med, Menninger Dept Psychiat & Behav Sci, Lee & Joe Jamail Specialty Care Ctr, 1977 Butler Blvd, Houston, TX 77030 USA.
   [Devaraj, Sridevi] Baylor Coll Med, Dept Pathol & Immunol, Houston, TX 77030 USA.
   [Devaraj, Sridevi] Texas Childrens Hosp, Dept Pathol & Immunol, Houston, TX 77030 USA.
   [Okusaga, Olaoluwa O.] Michael E DeBakey VA Med Ctr, Houston, TX 77030 USA.
C3 Baylor College of Medicine; Baylor College of Medicine; Baylor College
   of Medicine; Baylor College Medical Hospital; Baylor College of
   Medicine; Baylor College Medical Hospital
RP Okusaga, OO (corresponding author), Baylor Coll Med, Menninger Dept Psychiat & Behav Sci, Lee & Joe Jamail Specialty Care Ctr, 1977 Butler Blvd, Houston, TX 77030 USA.; Okusaga, OO (corresponding author), Michael E DeBakey VA Med Ctr, Houston, TX 77030 USA.
EM olaoluwa.okusaga@bcm.edu
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NR 56
TC 5
Z9 5
U1 0
U2 3
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0033-2720
EI 1573-6709
J9 PSYCHIAT QUART
JI Psychiatr. Q.
PD MAR
PY 2019
VL 90
IS 1
BP 101
EP 110
DI 10.1007/s11126-018-9606-3
PG 10
WC Psychiatry
WE Social Science Citation Index (SSCI)
SC Psychiatry
GA HQ2EM
UT WOS:000462212900008
PM 30315442
DA 2025-06-11
ER

PT J
AU Tanasov, A
   Tiplica, GS
AF Tanasov, Andrei
   Tiplica, George-Sorin
TI Erectile dysfunction in dermatology and venereology: From
   aetiopathogenic mechanisms to practical considerations for
   dermato-venereologists
SO JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
LA English
DT Review; Early Access
ID QUALITY-OF-LIFE; 4TH INTERNATIONAL CONSULTATION; LICHEN SIMPLEX
   CHRONICUS; SEXUAL DYSFUNCTION; SYSTEMIC-SCLEROSIS; ATOPIC-DERMATITIS;
   HERPES-ZOSTER; MEN; PSORIASIS; SILDENAFIL
AB Erectile dysfunction (ED) is an often undiagnosed but significantly prevalent condition among male dermato-venereological patients, characterized by a complex pathophysiology and a substantial impact on quality of life. This review aimed to synthesize recent literature on the increased risk of ED in skin diseases, the underlying pathogenic mechanisms-including vasculogenic, endocrine, neurogenic, psychogenic and immunologic pathways-as well as the dermatologist's role in managing patients' sexual health. Inflammatory conditions (e.g. psoriasis, atopic dermatitis, lichen simplex chronicus and chronic hand eczema), infections (viral, bacterial and fungal, including sexually transmitted infections), autoimmune conditions (e.g. scleroderma and pemphigus) and disorders of the apocrine and eccrine glands (such as hidradenitis suppurativa) have all been linked to ED. The multi-systemic nature of many dermatologic diseases has become increasingly evident due to their associations with cardiovascular and metabolic comorbidities (atherosclerosis, hypertension, metabolic syndrome and vitamin D deficiency), central and peripheral neuropathies, endocrine disorders (hypogonadism and diabetes mellitus) or genito-urinary sequelae of sexually transmitted infections, while psychogenic ED further highlights the major mental health burden of skin conditions. Dermatologists are in the unique position to evaluate patients' sexual function and risk factors, investigate potential causes through accessible routine tests, prescribe impotence medication, consider erectile and overall sexual function in the dermatologic treatment choice and provide integrative lifestyle recommendations. Addressing sexual health in dermatologic practice offers significant benefits for both patients and healthcare systems, improving compliance, reducing logistical challenges and optimizing financial outcomes.
C1 [Tanasov, Andrei; Tiplica, George-Sorin] Carol Davila Univ Med & Pharm, Eroii Sanitari 8, Bucharest 050474, Romania.
   [Tanasov, Andrei; Tiplica, George-Sorin] Colentina Clin Hosp, Dept Dermatol 2, Bucharest, Romania.
C3 Carol Davila University of Medicine & Pharmacy
RP Tanasov, A (corresponding author), Carol Davila Univ Med & Pharm, Eroii Sanitari 8, Bucharest 050474, Romania.
EM andrei.tanasov@drd.umfcd.ro
RI Tanasov, Andrei/GXG-4978-2022; TIPLICA, George/D-3135-2016
FX Open access publishing facilitated by Anelis Plus (the official name of
   "Asociatia Universitatilor, a Institutelor de Cercetare - Dezvoltare si
   a Bibliotecilor Centrale Universitare din Romania"), as part of the
   Wiley - Anelis Plus agreement.
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NR 127
TC 0
Z9 0
U1 6
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0926-9959
EI 1468-3083
J9 J EUR ACAD DERMATOL
JI J. Eur. Acad. Dermatol. Venereol.
PD 2025 MAR 8
PY 2025
DI 10.1111/jdv.20618
EA MAR 2025
PG 13
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA Z6C8T
UT WOS:001439770900001
PM 40055994
OA hybrid
DA 2025-06-11
ER

PT J
AU Prathiksha, AS
   Shantaram, PM
   Rashid, M
   Poojari, PG
   Nair, S
   Acharya, LD
   Thunga, G
AF Prathiksha, A. S.
   Shantaram, Pawar Mansi
   Rashid, Muhammed
   Poojari, Pooja Gopal
   Nair, Sreedharan
   Acharya, Leelavathi D.
   Thunga, Girish
TI Determinants of and barriers to diabetes care among patients with
   serious mental illness: A scoping review with recommendations
SO DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS
LA English
DT Review
DE diabetes care; Mental health; Metabolic syndrome; Patient adherence;
   Clinical outcomes
ID HEALTH-CARE; QUALITY; SCHIZOPHRENIA; MANAGEMENT; OUTCOMES;
   INTERVENTIONS; PEOPLE; ADULTS; IMPACT
AB Aim: We performed a scoping review to identify the diabetes care determinants and barriers in patients with serious mental illness (SMI), in view of limited evidence and clarity. Methods: We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) Guidelines. PubMed, EMBASE, and Scopus were searched from inception to September 2023 to identify eligible studies. Observational studies that reported the determinants of and barriers to diabetes care among SMI patients were considered. A narrative synthesis of review results was performed to gather evidence. Recommendations were framed in the context of this evidence. Results: Of the 8727 non-duplicate records, only 10 studies that met the inclusion criteria were considered for this review. Of these, four were cohort, two were case-control, and four were cross-sectional in design. All 10 studies were observed to have robust methodologies. Diabetes measures examined in these studies included not only the Healthcare Effectiveness Data and Information Set (HEDIS) measures (HbA1c, retinopathy, nephropathy, and blood pressure), but also lipid, foot, and BMI. Factors contributing to inadequate diabetes care can be attributed to the healthcare system, healthcare providers, and at the patient-level. Conclusion: Currently, there is lack of evidence on determinants of quality diabetes care among SMI patients. Further, adequately powered long term follow-up studies are needed to understand the impact of diabetes care on their clinical outcomes.
C1 [Prathiksha, A. S.; Shantaram, Pawar Mansi; Rashid, Muhammed; Poojari, Pooja Gopal; Nair, Sreedharan; Acharya, Leelavathi D.; Thunga, Girish] Manipal Acad Higher Educ, Manipal Coll Pharmaceut Sci, Dept Pharm Practice, Manipal 576104, Karnataka, India.
   [Thunga, Girish] Manipal Acad Higher Educ, Manipal Coll Pharmaceut Sci, Ctr Toxicovigilance & Drug Safety, Manipal 576104, Karnataka, India.
C3 Manipal Academy of Higher Education (MAHE); Manipal Academy of Higher
   Education (MAHE)
RP Thunga, G (corresponding author), Manipal Acad Higher Educ, Manipal Coll Pharmaceut Sci, Dept Pharm Practice, Manipal 576104, Karnataka, India.
EM girish.thunga@manipal.edu
RI , Sreedharan/AGJ-7376-2022; Rashid, Muhammed/AAP-1945-2020
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NR 56
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 1871-4021
EI 1878-0334
J9 DIAB MET SYND CLIN R
JI DIABET. METAB. SYNDR. CLIN. RES. REV.
PD OCT
PY 2024
VL 18
IS 10
AR 103139
DI 10.1016/j.dsx.2024.103139
EA OCT 2024
PG 11
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA K7E3Z
UT WOS:001345467300001
PM 39490236
DA 2025-06-11
ER

PT J
AU Ugarte, E
   Johnson, LE
   Robins, RW
   Guyer, AE
   Hastings, PD
AF Ugarte, Elisa
   Johnson, Lisa E.
   Robins, Richard W.
   Guyer, Amanda E.
   Hastings, Paul D.
TI The impact of social disadvantage on autonomic physiology of latinx
   adolescents: The role of environmental risks
SO NEW DIRECTIONS FOR CHILD AND ADOLESCENT DEVELOPMENT
LA English
DT Article
DE adolescence; environmental toxins; latinx; poverty; riskscapes autonomic
   nervous system
ID HEART-RATE-VARIABILITY; RESPIRATORY SINUS ARRHYTHMIA; NERVOUS-SYSTEM;
   AIR-POLLUTION; ALLOSTATIC LOAD; SOCIOECONOMIC DISPARITIES; BIOLOGICAL
   SENSITIVITY; HOUSING AFFORDABILITY; COMMUNITIES EVIDENCE; METABOLIC
   SYNDROME
AB The experience of poverty embodies complex, multidimensional stressors that may adversely affect physiological and psychological domains of functioning. Compounded by racial/ethnic discrimination, the financial aspect of family poverty typically coincides with additional social and physical environmental risks such as pollution exposure, housing burden, elevated neighborhood unemployment, and lower neighborhood education levels. In this study, we investigated the associations of multidimensional social disadvantage throughout adolescence with autonomic nervous system (ANS) functioning at 17 years. Two hundred and twenty nine low-income Mexican-American adolescents (48.6% female) and their parents were assessed annually between the ages of 10 and 16. Participants' census tracts were matched with corresponding annual administrative data of neighborhood housing burden, education, unemployment, drinking water quality, and fine particulate matter. We combined measures of adolescents' electrodermal response and respiratory sinuses arrhythmia at rest and during a social exclusion challenge (Cyberball) to use as ANS indices of sympathetic and parasympathetic activity, respectively. Controlling for family income-to-needs, youth exposed to greater cumulative water and air pollution from ages 10-16 displayed altered patterns of autonomic functioning at rest and during the social challenge. Conversely, youth living in areas with higher housing burden displayed healthy patterns of autonomic functioning. Altogether, results suggest that toxin exposure in youths' physical environments disrupts the ANS, representing a plausible mechanism by which pollutants and social disadvantage influence later physical and mental health.
C1 [Ugarte, Elisa; Guyer, Amanda E.] Univ Calif Davis, Dept Human Ecol, Davis, CA 95618 USA.
   [Ugarte, Elisa; Johnson, Lisa E.; Robins, Richard W.; Guyer, Amanda E.; Hastings, Paul D.] Univ Calif Davis, Ctr Mind & Brain, Davis, CA 95618 USA.
   [Johnson, Lisa E.; Hastings, Paul D.] Univ Calif Davis, Dept Psychol, Davis, CA 95618 USA.
C3 University of California System; University of California Davis;
   University of California System; University of California Davis;
   University of California System; University of California Davis
RP Ugarte, E; Johnson, LE (corresponding author), Univ Calif Davis, 202 Cousteau Pl,Suite 267, Davis, CA 95618 USA.
EM eugarte@ucdavis.edu; lisjohnson@ucdavis.edu
RI Guyer, Amanda/AAG-2459-2019
OI Ugarte, Elisa/0000-0003-1803-9619; Johnson, Lisa/0000-0002-9156-6530
FU National Institute of Health [R01MH098370, R01DA017902]; ANID
   [72180409]; UC Network on Child Health, Poverty, and Public Policy
   graduate student training grant
FX National Institute of Health, Grant/Award Numbers: R01MH098370,
   R01DA017902; ANID, Grant/Award Number: 72180409; UC Network on Child
   Health, Poverty, and Public Policy graduate student training grant
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NR 157
TC 5
Z9 7
U1 2
U2 10
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1520-3247
EI 1534-8687
J9 NEW DIR CHILD ADOLES
JI New Dir. Child Adoles.
PD MAR
PY 2022
VL 2022
IS 181-182
SI SI
BP 91
EP 124
DI 10.1002/cad.20462
PG 34
WC Psychology, Developmental; Sociology
WE Social Science Citation Index (SSCI)
SC Psychology; Sociology
GA 4P8HP
UT WOS:000855631200007
PM 35634899
OA Green Submitted, gold, Green Accepted
DA 2025-06-11
ER

PT J
AU Wang, H
   Zhong, JM
   Hu, RY
   Fiona, B
   Yu, M
   Du, HD
AF Wang, Hao
   Zhong, Jieming
   Hu, Ruying
   Fiona, Bragg
   Yu, Min
   Du, Huaidong
TI Prevalence of high screen time and associated factors among students: a
   cross-sectional study in Zhejiang, China
SO BMJ OPEN
LA English
DT Article
ID RISK BEHAVIOR SURVEILLANCE; SUGAR-SWEETENED BEVERAGES; SEDENTARY
   BEHAVIOR; METABOLIC SYNDROME; PHYSICAL-ACTIVITY; MENTAL-HEALTH;
   ADOLESCENTS; CHILDREN; CONSUMPTION; OBESITY
AB Objective To investigate the prevalence and correlates of high screen time (Si) among students in Zhejiang, China.
   Design Cross-sectional study.
   Setting School-based adolescent health survey in Zhejiang Province, China.
   Participants 23 543 students in grades 7-12 from 442 different schools.
   Outcome High ST.
   Results The mean age of the students was 15.6 years and 49.7% of them were girls. The prevalence of high ST (screen viewing >= 2 hours per day) was 42.4% (95% CI 40.2% to 44.5%), higher in boys than in girls (45.4%(95% CI 42.8% to 48.0%) vs 39.1% (95% CI 36.6% to 41.7%)). No statistically significant difference was found between urban and rural areas (43.0% (95% CI 37.2% to 48.7%) vs 42.1% (95% CI 39.6% to 44.6%)). The prevalence of high ST among middle school, academic high school and vocational high school students was 35.3%, 30.0% and 73.5%, respectively. Multivariable logistic analysis showed that older age, attendance at vocational high school, non-intact family, poor academic performance, bad self-reported health status, loneliness and drinking carbonated beverages >= 3 times every day were positively associated with high ST. Attendance at academic high school, higher parental education and being physically active were negatively associated with high ST.
   Conclusions High ST was prevalent among students and associated with a duster of sociodemographic and behavioural risk factors in Zhejiang, China.
C1 [Wang, Hao; Zhong, Jieming; Hu, Ruying; Yu, Min] Zhejiang Prov Ctr Dis Control & Prevent, Dept NCDs Control & Prevent, Hangzhou, Zhejiang, Peoples R China.
   [Fiona, Bragg; Du, Huaidong] Univ Oxford, Nuffield Dept Populat Hlth, Clin Trial Serv Unit, Oxford, England.
   [Fiona, Bragg; Du, Huaidong] Univ Oxford, Nuffield Dept Populat Hlth, Epidemiol Studies Unit CTSU, Oxford, England.
   [Du, Huaidong] Univ Oxford, Populat Hlth Res Unit, Nuffield Dept Populat Hlth, MRC, Oxford, England.
C3 Zhejiang Provincial Center for Disease Control & Prevention; University
   of Oxford; University of Oxford; University of Oxford
RP Yu, M (corresponding author), Zhejiang Prov Ctr Dis Control & Prevent, Dept NCDs Control & Prevent, Hangzhou, Zhejiang, Peoples R China.
EM myu@cdc.zj.cn
RI , Bennett/O-7998-2019; Zhong, Jieming/GPC-7334-2022
OI Du, Huaidong/0000-0002-9814-0049; Bragg, Fiona/0000-0002-9181-6886
FU National Key Research and Development Program of China [2016YFC0900502]
FX The work was supported by grant (2016YFC0900502) from National Key
   Research and Development Program of China.
CR [Anonymous], J OBESITY
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NR 49
TC 28
Z9 29
U1 0
U2 21
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2044-6055
J9 BMJ OPEN
JI BMJ Open
PD JUN
PY 2018
VL 8
IS 6
AR e021493
DI 10.1136/bmjopen-2018-021493
PG 9
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA GJ7LG
UT WOS:000435567900089
PM 29921687
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Boettger, S
   Wetzig, F
   Puta, C
   Donath, L
   Müller, HJ
   Gabriel, HHW
   Bär, KJ
AF Boettger, Silke
   Wetzig, Franziska
   Puta, Christian
   Donath, Lars
   Mueller, Hans-Josef
   Gabriel, Holger H. W.
   Baer, Karl-Juergen
TI Physical Fitness and Heart Rate Recovery Are Decreased in Major
   Depressive Disorder
SO PSYCHOSOMATIC MEDICINE
LA English
DT Article
DE physical fitness; peak oxygen consumption; individual anaerobic
   threshold; heart rate recovery; major depressive disorder; autonomic
   nervous system
ID MENTAL-HEALTH; EXERCISE; RESPONSES; MORTALITY; INTENSITY; PREDICTOR;
   SYMPTOMS; DISEASE; OBESITY; UPDATE
AB Objective: To investigate whether physical fitness is decreased in patients with major depressive disorder (MDD) in comparison to matched healthy controls because low physical fitness has been shown to be associated with metabolic syndrome or autonomic dysfunction. Cardiovascular morbidity and mortality are known to be increased in patients with MDD. Furthermore, the effect of a single exhaustive exercise task on heart rate recovery (HRR) and mood was examined. Methods: Peak oxygen consumption (VO(2)peak), maximum workload (Ppeak), and individual anaerobic threshold (IAT) were assessed in 22 patients suffering from MDD and 22 controls in a stepwise exhaustion protocol, using spirometry and lactate diagnostics. HRR was detected within the first minute after recovery, The Self-Assessment Manikin (SAM) was used to assess mood before and after exercise. Results: VO(2)peak, Ppeak, and IAT were decreased significantly in patients, indicating reduced physical fitness in MDD as compared with control subjects. A single exercise exhaustion significantly improved mood in patients, but not in controls. Mood improvement ill patients correlated with maximum lactate levels. Significantly reduced HRR values in patients further point to an elevated cardiovascular risk profile and autonomic dysfunction. Conclusions: Our results indicate reduced physical fitness in patients with MDD. Thus, special training programs should be developed to improve their cardiovascular risk profile. In addition, the intriguing finding of a correlation between lactate levels and mood changes should be followed up in future studies to unravel putative mechanisms.
C1 [Boettger, Silke; Wetzig, Franziska; Baer, Karl-Juergen] Univ Hosp Jena, Dept Psychiat & Psychotherapy, D-07743 Jena, Germany.
   [Puta, Christian; Donath, Lars; Mueller, Hans-Josef; Gabriel, Holger H. W.] Univ Jena, Dept Sports Med, Jena, Germany.
C3 Friedrich Schiller University of Jena; Friedrich Schiller University of
   Jena
RP Bär, KJ (corresponding author), Univ Hosp Jena, Dept Psychiat & Psychotherapy, Philosophenweg 3, D-07743 Jena, Germany.
EM Karl-Juergen.Baer@med.uni-jena.de
RI ; Puta, Christian/P-5562-2014
OI Donath, Lars/0000-0001-6039-0141; Puta, Christian/0000-0003-3936-4605
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NR 42
TC 46
Z9 50
U1 1
U2 13
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0033-3174
EI 1534-7796
J9 PSYCHOSOM MED
JI Psychosom. Med.
PD JUN
PY 2009
VL 71
IS 5
BP 519
EP 523
DI 10.1097/PSY.0b013e3181a55303
PG 5
WC Psychiatry; Psychology; Psychology, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry; Psychology
GA 459YC
UT WOS:000267148200006
PM 19414614
DA 2025-06-11
ER

PT J
AU Wen, ZB
   Kim, Y
   Choi, Y
AF Wen, Zebin
   Kim, Yonghwan
   Choi, Yongchul
TI Effects of Exercise Program on Mental, Pulmonary, and Cardiovascular
   Health of Elderly Men with Acquired Severe Physical Disabilities: A
   Retrospective Study
SO HEALTHCARE
LA English
DT Article
DE physical disabilities; quality of life; activity; metabolic health;
   welfare
ID SPINAL-CORD-INJURY; ASSOCIATIONS; MOBILITY; WOMEN; RISK
AB Background/Objectives: Physical activity is recommended for people with physical disabilities and is beneficial not only for physical health but also for mental health. This study aimed to evaluate the quality of life (QoL), pulmonary health, and cardiovascular health among a group of older men with physical disabilities who participated in an exercise program. Methods: This study included 23 participants in the exercise group (EG) as an experimental group and 23 in the culture group (CG) as a control group. All participants were >= 65 years, with one or more physical disabilities, and used wheelchairs or crutches for mobility. The participants were each provided with the exercise program for 8 weeks. Assessments included a QoL, pulmonary function test, brachial-ankle pulse wave velocity (baPWV), and factors of metabolic syndrome. The exercise program consisted of aerobics, strength training using dumbbells and tubes, and mat exercises for three days a week for 8 weeks. The culture program included singing, drawing, and writing. Results: The interaction effects by time and group showed that EG had a superior change compared to CG in QoL (physical function, pain, fatigue, social), forced vital capacity, baPWV, triglycerides, and high-density lipoprotein cholesterol (p < 0.05). Conclusions: Participation in the exercise program positively influenced mental, pulmonary, and cardiovascular health in older men with physical disabilities. Our research results will provide useful information for rehabilitation and social security research to improve the health of elderly people with physical disabilities.
C1 [Wen, Zebin] Taiyuan Univ Technol, Coll Phys Educ, Taiyuan 030024, Peoples R China.
   [Kim, Yonghwan; Choi, Yongchul] Gangneung Wonju Natl Univ, Dept Phys Educ, Kangnung 25457, South Korea.
   [Kim, Yonghwan] Univ Houston, Dept Hlth & Human Performance, Lab Integrated Physiol, Houston, TX 77204 USA.
C3 Taiyuan University of Technology; Gangneung-Wonju National University;
   University of Houston System; University of Houston
RP Choi, Y (corresponding author), Gangneung Wonju Natl Univ, Dept Phys Educ, Kangnung 25457, South Korea.
EM wenzebin@tyut.edu.cn; yhkim@gwnu.ac.kr; ycchoi@gwnu.ac.kr
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NR 56
TC 0
Z9 0
U1 1
U2 1
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2227-9032
J9 HEALTHCARE-BASEL
JI Healthcare
PD MAR 9
PY 2025
VL 13
IS 6
AR 597
DI 10.3390/healthcare13060597
PG 14
WC Health Care Sciences & Services; Health Policy & Services
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services
GA 0PE1L
UT WOS:001452702600001
PM 40150447
OA gold
DA 2025-06-11
ER

PT J
AU Schoemans, H
   Goris, K
   Fieuws, S
   Theunissen, K
   Buve, K
   Lammertijn, L
   Bries, G
   Demuynck, H
   Maertens, V
   Maes, H
   Meers, S
   Schuermans, C
   Vrelust, I
   De Samblanx, H
   Huysmans, G
   Vergote, V
   Beckers, M
   Maertens, J
   De Geest, S
   Dobbels, F
AF Schoemans, Helene
   Goris, Kathy
   Fieuws, Steffen
   Theunissen, Koen
   Buve, Kristel
   Lammertijn, Liesbet
   Bries, Greet
   Demuynck, Hilde
   Maertens, Vincent
   Maes, Helena
   Meers, Stef
   Schuermans, Christine
   Vrelust, Inge
   De Samblanx, Hadewijch
   Huysmans, Griet
   Vergote, Vibeke
   Beckers, Marielle
   Maertens, Johan
   De Geest, Sabina
   Dobbels, Fabienne
TI Life 2.0: a comprehensive cross-sectional profiling of long-term
   allogeneic hematopoietic cell transplantation survivors compared to a
   matched general population cohort
SO BONE MARROW TRANSPLANTATION
LA English
DT Article
ID QUALITY-OF-LIFE; BONE-MARROW-TRANSPLANTATION; RISK-FACTORS; FUNCTIONAL
   STATUS; HIGH PREVALENCE; HEALTH; RECIPIENTS; OUTCOMES; IMPACT; CARE
AB Long-term survivors after allogeneic cell transplantation (HCT) have unique needs. We performed a cross-sectional case-control study to describe the survivorship profile of 244 adult allogeneic transplantation recipients at a median of 8.4 years post-HCT and compared it to controls from the general population (matched 1:3 based on age, gender, and province of residence). The most prevalent medical complications were graft versus host disease (46.7%), impaired kidney function (63.9%), and the presence of a metabolic syndrome (33.6%). Survivors were significantly more likely to report a sub-optimal perceived health status than controls (82.0% versus 52.1% respectively, OR 4.57, p < 0.0001). They also reported significantly lower employment rates (42.6% versus 55.6% respectively, OR 0.389, p < 0.0001) and more polypharmacy (32.0% versus 9.6% respectively, OR 5.0, p < 0.0001) than matched counterparts. Social support and mental health were generally preserved. Apart for a concerning tendency to medication non-adherence, low physical activity (54.5%), and inappropriate exposition to UV (44.7%), health-related behavior was adequate. Many survivors have a health status comparable to chronically ill patients and, if so, should be managed as such. Novel patient-centered initiatives based on chronic care models could support survivors in preventing and dealing with long-term complications, regaining functionality, and returning to their role in society.
C1 [Schoemans, Helene; Goris, Kathy; Vergote, Vibeke; Beckers, Marielle; Maertens, Johan] Univ Hosp Leuven, Dept Hematol, Leuven, Belgium.
   [Schoemans, Helene; De Geest, Sabina; Dobbels, Fabienne] Katholieke Univ Leuven, Acad Ctr Nursing & Midwifery, Dept Publ Hlth & Primary Care, Leuven, Belgium.
   [Fieuws, Steffen] KU Leuven Univ Leuven, L BioStat, Leuven, Belgium.
   [Fieuws, Steffen] Univ Hasselt, Leuven, Belgium.
   [Theunissen, Koen; Buve, Kristel; Lammertijn, Liesbet] Jessa Ziekenhuis, Hematol, Campus Virga Jesse, Hasselt, Belgium.
   [Bries, Greet] AZ Herentals, Orthoped Dept, Herentals, Belgium.
   [Demuynck, Hilde] Jan Yperman Ziekenhuis, Dept Pathol, Ieper, Belgium.
   [Maertens, Vincent; Maes, Helena] Imeldaziekenhuis Bonheiden, Dept Radiol, Bonheiden, Belgium.
   [Meers, Stef] AZ KLINA, Dept Gynaecol, Antwerp, Belgium.
   [Schuermans, Christine] GZA St Augustinus, Dept Hematol, B-2610 Antwerp, Belgium.
   [Vrelust, Inge] AZ Turnhout, Dept Hematol, Turnhout, Belgium.
   [De Samblanx, Hadewijch] Ziekenhuis Geel, Dept Hematol, Geel, Belgium.
   [Huysmans, Griet] AZ Nikolaas, Dept Hematol, St Niklaas, Belgium.
   [De Geest, Sabina] Univ Basel, Inst Nursing Sci, Dept Publ Hlth, Basel, Switzerland.
C3 KU Leuven; University Hospital Leuven; KU Leuven; KU Leuven; Hasselt
   University; Imeldaziekenhuis; University of Basel
RP Schoemans, H (corresponding author), Univ Hosp Leuven, Dept Hematol, Leuven, Belgium.; Schoemans, H (corresponding author), Katholieke Univ Leuven, Acad Ctr Nursing & Midwifery, Dept Publ Hlth & Primary Care, Leuven, Belgium.
EM Helene.schoemans@uzleuven.be
RI De Geest, Sabina/F-7724-2010; Maertens, Johan/C-2607-2018; Schoemans,
   Helene/AAG-6710-2020
OI Beckers, Marielle/0000-0001-7010-0427; DE GEEST,
   SABINA/0000-0001-6596-7237; Schoemans, Helene/0000-0002-7568-8239
FU HS acknowledges the support of the UZ Leuven Klinische onderzoeks- en
   opleidingsraad (KOOR) and the Sofhea Leerstoel in de
   Stamceltransplantatie.
FX We thank all patients and family members who have participated in this
   study, as well as all the healthcare professionals who facilitated study
   completion.
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NR 75
TC 0
Z9 0
U1 1
U2 1
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0268-3369
EI 1476-5365
J9 BONE MARROW TRANSPL
JI Bone Marrow Transplant.
PD APR
PY 2025
VL 60
IS 4
BP 507
EP 518
DI 10.1038/s41409-025-02521-5
EA FEB 2025
PG 12
WC Biophysics; Oncology; Hematology; Immunology; Transplantation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biophysics; Oncology; Hematology; Immunology; Transplantation
GA 0YX7C
UT WOS:001415642500001
PM 39915542
DA 2025-06-11
ER

PT J
AU Yu, CJ
   Du, JC
   Chiou, HC
   Feng, CC
   Chung, MY
   Yang, WN
   Chen, YS
   Chien, LC
   Hwang, BT
   Chen, ML
AF Yu, Ching-Jung
   Du, Jung-Chieh
   Chiou, Hsien-Chih
   Feng, Chun-Cheng
   Chung, Ming-Yi
   Yang, Winnie
   Chen, Ying-Sheue
   Chien, Ling-Chu
   Hwang, Betau
   Chen, Mei-Lien
TI Sugar-Sweetened Beverage Consumption Is Adversely Associated with
   Childhood Attention Deficit/Hyperactivity Disorder
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Article
DE ADHD; sugar-sweetened beverage; artificial food coloring; preservative;
   case-control; blood lead level; gene polymorphism; children
ID DEFICIT HYPERACTIVITY DISORDER; ARTIFICIAL FOOD COLORS; BLOOD LEAD
   LEVELS; VERSION-IV SCALE; METABOLIC SYNDROME; PSYCHOMETRIC PROPERTIES;
   RISK-FACTORS; DIETARY PATTERNS; CHINESE VERSION; SCHOOL-CHILDREN
AB Attention deficit/hyperactivity disorder (ADHD) is one of the most common childhood neurobehavioral conditions. Evidence of the negative effects of sugar-sweetened beverages (SSBs) on mental health has not been convincing, although a few studies have found an association between high SSB levels and attention problems in children. This study aimed to test the hypothesis that SSB consumption is associated with ADHD among children. Doctor-diagnosed ADHD cases (n = 173) and non-ADHD controls (n = 159) between age 4 to 15 were recruited. SSB consumption, socio-demographic and lifestyle characteristics of the children, as well as of their mothers' characteristics during pregnancy, were collected using a questionnaire. Blood lead levels and polymorphisms of two commonly verified dopaminergic-related genes (the D4 dopamine receptor gene DRD4 and the dopamine transporter gene DAT1) were also analyzed. There was a dose-response relationship between SSB consumption and ADHD. After covariates were adjusted, children who consumed SSBs at moderate levels and high levels had 1.36 and 3.69 odds, respectively, of having ADHD, compared with those who did not consume SSBs (p for trend <0.05). Similar results were obtained when females were excluded. Our findings highlighted the adverse correlation between SSB consumption and ADHD and indicated a dose-response effect even after covariates were adjusted.
C1 [Yu, Ching-Jung; Feng, Chun-Cheng; Chen, Mei-Lien] Natl Yang Ming Univ, Sch Med, Inst Environm & Occupat Hlth Sci, Taipei 11221, Taiwan.
   [Du, Jung-Chieh; Hwang, Betau] Taipei City Hosp, Zhongxiao Branch, Dept Pediat, Taipei 11556, Taiwan.
   [Chiou, Hsien-Chih] Taipei City Hosp, Dept Child & Adolescent Psychiat, Songde Branch, Taipei 11080, Taiwan.
   [Chung, Ming-Yi] Natl Yang Ming Univ, Dept Life Sci, Taipei 11221, Taiwan.
   [Chung, Ming-Yi] Natl Yang Ming Univ, Inst Genome Sci, Taipei 11221, Taiwan.
   [Yang, Winnie] Taipei City Hosp, Dept Pediat, Yangming Branch, Taipei 11146, Taiwan.
   [Chen, Ying-Sheue] Taipei Vet Gen Hosp, Dept Psychiat, Taipei 11217, Taiwan.
   [Chien, Ling-Chu] Taipei Med Univ, Sch Publ Hlth, Taipei 11031, Taiwan.
C3 National Yang Ming Chiao Tung University; Taipei City Hospital; Taipei
   City Hospital; National Yang Ming Chiao Tung University; National Yang
   Ming Chiao Tung University; Taipei City Hospital; Taipei Veterans
   General Hospital; Taipei Medical University
RP Chen, ML (corresponding author), Natl Yang Ming Univ, Sch Med, Inst Environm & Occupat Hlth Sci, Taipei 11221, Taiwan.
EM d49521001@ym.edu.tw; DAL82@tpech.gov.tw; DAF28@tpech.gov.tw;
   ryan.feng@gmail.com; mychung@ym.edu.tw; DAH06@tpech.gov.tw;
   drchen3209@gmail.com; lcchien@tmu.edu.tw; dan75@tpech.gov.tw;
   mlchen@ym.edu.tw
RI Yang, Wenning/KOZ-7804-2024; Lai, Chern-Hsiung/C-8662-2009
OI Chien, Ling-Chu/0000-0001-5539-8974
FU Department of Health, Taipei City Government; Aiming for the Top
   University Plan from the Ministry of Education of the Republic of China,
   Taiwan; National Science Council of Taiwan [NSC 96-2314-B-010-020-MY3];
   National Core Facility Program for Biotechnology, Taiwan (MOST)
   [103-2319-B-010-001]
FX We are thankful for the financial support provided by the Department of
   Health, Taipei City Government, and Aiming for the Top University Plan
   from the Ministry of Education of the Republic of China, Taiwan. The
   work was also supported by grant NSC 96-2314-B-010-020-MY3 from the
   National Science Council of Taiwan. We also acknowledge the
   High-throughput Genome Analysis Core Facility of the National Core
   Facility Program for Biotechnology, Taiwan (MOST 103-2319-B-010-001) for
   SNP genotyping. This manuscript was edited by American Journal Experts.
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NR 102
TC 42
Z9 51
U1 2
U2 70
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD JUL
PY 2016
VL 13
IS 7
AR 678
DI 10.3390/ijerph13070678
PG 18
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA DS4OG
UT WOS:000380759800054
PM 27384573
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Köhler-Forsberg, O
   Sylvia, LG
   Thase, M
   Calabrese, JR
   Tohen, M
   Bowden, CL
   McInnis, M
   Iosifescu, D
   Kocsis, JH
   Friedman, ES
   Ketter, TA
   McElroy, SL
   Shelton, RC
   Fung, V
   Ostacher, MJ
   Nierenberg, AA
AF Kohler-Forsberg, Ole
   Sylvia, Louisa G.
   Thase, Michael
   Calabrese, Joseph R.
   Tohen, Mauricio
   Bowden, Charles L.
   McInnis, Melvin
   Iosifescu, Dan, V
   Kocsis, James H.
   Friedman, Edward S.
   Ketter, Terence A.
   McElroy, Susan L.
   Shelton, Richard C.
   Fung, Vicki
   Ostacher, Michael J.
   Nierenberg, Andrew A.
TI Lithium plus antipsychotics or anticonvulsants for bipolar disorder:
   Comparing clinical response and metabolic changes
SO AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
LA English
DT Article
DE Bipolar disorder; lithium; antipsychotic; anticonvulsant; bipolar
   depression
ID MODERATE-DOSE-USE; COMPARATIVE EFFICACY; TRIAL; ACCEPTABILITY;
   PSYCHIATRISTS; MONOTHERAPY; QUETIAPINE; NATIONWIDE; VALPROATE; LITMUS
AB Objective: Patients with bipolar disorder treated with lithium often require additional antipsychotics or anticonvulsants. However, the comparative effectiveness and safety of these agents as add-on to lithium has not been studied. Methods: This secondary analysis combined two similar 24-week trials on outpatients with bipolar disorder randomized to lithium (target serum level 0.4-0.6 mEq/L). Guideline-based adjunctive antipsychotics (Li+AP) and anticonvulsants (Li+AC) could be used if clinically indicated and was assessed at every study visit. Response was measured on the Clinical Global Impression scale and we performed adjusted mixed effects linear regression analyses. Analysis of variance tests compared metabolic measures including a binary diagnosis of metabolic syndrome before and after 24 weeks of treatment. Results: Among 379 outpatients (57% female, mean age 38 years, mean Clinical Global Impression 4.4), users of Li+AP (N = 50, primarily quetiapine and aripiprazole) improved to a similar degree (mean Clinical Global Impression improvement = 1.6, standard deviation = 1.5) as those using lithium-only (i.e. without adjunctive antipsychotics or anticonvulsants, N = 149, mean Clinical Global Impression improvement = 1.7, standard deviation = 1.4) (p = 0.59). Users of Li+AC (N = 107, primarily lamotrigine and valproate, mean Clinical Global Impression improvement = 1.2, standard deviation = 1.3) and users of Li+AP+AC (N = 73, mean Clinical Global Impression improvement = 1.1, standard deviation = 1.3) showed worse response compared to lithium-only users (all p < 0.01). When comparing Li+AP to Li+AC, users of Li+AP improved slightly better on general (p = 0.05) and manic symptoms (p = 0.01), but showed a worse development of glucose, triglycerides, and metabolic syndrome. Conclusion: Despite treatment-by-indication confounding, these findings are relevant for real-world treatment settings and emphasize the need for randomized trials on this clinically important topic.
C1 [Kohler-Forsberg, Ole] Aarhus Univ Hosp Psychiat, Psychosis Res Unit, DK-8200 Aarhus, Denmark.
   [Kohler-Forsberg, Ole] Aarhus Univ, Dept Clin Med, Aarhus, Denmark.
   [Kohler-Forsberg, Ole; Sylvia, Louisa G.; Iosifescu, Dan, V; Nierenberg, Andrew A.] Massachusetts Gen Hosp, Dept Psychiat, Boston, MA 02114 USA.
   [Kohler-Forsberg, Ole; Sylvia, Louisa G.; Iosifescu, Dan, V; Nierenberg, Andrew A.] Harvard Med Sch, Boston, MA 02115 USA.
   [Thase, Michael] Univ Penn, Dept Psychiat, Philadelphia, PA 19104 USA.
   [Calabrese, Joseph R.] Case Western Reserve Univ, Dept Psychiat, Cleveland, OH 44106 USA.
   [Tohen, Mauricio] Univ New Mexico, Dept Psychiat, Hlth Sci Ctr, Albuquerque, NM 87131 USA.
   [Bowden, Charles L.] Univ Texas Hlth Sci Ctr San Antonio, Dept Psychiat, San Antonio, TX 78229 USA.
   [McInnis, Melvin] Univ Michigan, Dept Psychiat, Ann Arbor, MI 48109 USA.
   [Kocsis, James H.] Weill Cornell Med Coll, Dept Psychiat, New York, NY USA.
   [Friedman, Edward S.] Univ Pittsburgh, Med Ctr, Dept Psychiat, Pittsburgh, PA USA.
   [Ketter, Terence A.; Ostacher, Michael J.] Stanford Univ, Dept Psychiat & Behav Sci, Sch Med, Stanford, CA 94305 USA.
   [McElroy, Susan L.] Univ Cincinnati, Coll Med, Dept Psychiat & Behav Neurosci, Cincinnati, OH USA.
   [McElroy, Susan L.] Lindner Ctr HOPE, Dept Psychiat, Mason, OH USA.
   [Shelton, Richard C.] Univ Alabama Birmingham, Dept Psychiat, Birmingham, AL USA.
   [Fung, Vicki] Massachusetts Gen Hosp, Dept Psychiat, Mongan Inst, Boston, MA 02114 USA.
   [Fung, Vicki] Harvard Med Sch, Dept Med, Boston, MA 02115 USA.
C3 Aarhus University; Harvard University; Harvard University Medical
   Affiliates; Massachusetts General Hospital; Harvard University; Harvard
   Medical School; University of Pennsylvania; University System of Ohio;
   Case Western Reserve University; University of New Mexico's Health
   Sciences Center; University of New Mexico; University of Texas System;
   University of Texas Health Science Center at San Antonio; University of
   Michigan System; University of Michigan; Cornell University; Weill
   Cornell Medicine; Pennsylvania Commonwealth System of Higher Education
   (PCSHE); University of Pittsburgh; Stanford University; University
   System of Ohio; University of Cincinnati; University of Alabama System;
   University of Alabama Birmingham; Harvard University; Harvard University
   Medical Affiliates; Massachusetts General Hospital; Harvard University;
   Harvard Medical School
RP Köhler-Forsberg, O (corresponding author), Aarhus Univ Hosp Psychiat, Psychosis Res Unit, DK-8200 Aarhus, Denmark.
EM karkoe@rm.dk
RI Ostacher, Michael/AFK-7519-2022; Nierenberg, ANierenberg/IAR-5549-2023;
   Iosifescu, Dan/L-3305-2019; Shelton, Richard/AAC-4137-2022; Sylvia,
   Louisa/AAE-8027-2022; McInnis, Melvin/F-6963-2012
OI Ostacher, Michael/0000-0003-0353-7535; Kohler-Forsberg,
   Ole/0000-0001-5121-1287
FU Agency for Healthcare Research and Quality (AHRQ) [1R01HS019371-01];
   NIMH [NO1MH80001]
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship and/or publication of this article: The Bipolar
   CHOICE trial was funded by the Agency for Healthcare Research and
   Quality (AHRQ): 1R01HS019371-01. The LiTMUS trial was funded by the
   NIMH: NO1MH80001.
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NR 25
TC 8
Z9 9
U1 0
U2 3
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0004-8674
EI 1440-1614
J9 AUST NZ J PSYCHIAT
JI Aust. N. Z. J. Psych.
PD JAN
PY 2023
VL 57
IS 1
BP 93
EP 103
AR 00048674221077619
DI 10.1177/00048674221077619
EA FEB 2022
PG 11
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 7I2RD
UT WOS:000759293000001
PM 35164524
DA 2025-06-11
ER

PT J
AU Khattab, R
AF Khattab, Rabie
TI Weight Loss Programs: Why Do They Fail? A Multidimensional Approach for
   Obesity Management
SO CURRENT NUTRITION REPORTS
LA English
DT Review
DE Weight loss programs; Obesity management; Holistic approach; Effective
   weight management strategies; Sustainable weight loss
ID TYPE-2 DIABETES-MELLITUS; METABOLIC SYNDROME; PHYSICAL-ACTIVITY; LOSS
   MAINTENANCE; BODY-WEIGHT; BEHAVIORAL TREATMENT; CARDIOVASCULAR RISK;
   DIETARY-MANAGEMENT; SLEEP DURATION; MENTAL-HEALTH
AB Purpose of ReviewDespite the prevalence of weight loss programs, their success rates remain discouraging, with around half of individuals regaining lost weight within two years. The primary objective of this review is to explore the factors contributing to the failure of weight loss programs and to provide insights into effective weight management strategies.Recent FindingsFactors contributing to the failure of weight loss programs include the impracticality of restrictive diets, potential metabolic impacts, limited focus on lifestyle changes, genetic predispositions, psychological influences, socioeconomic status, and medical conditions. A holistic approach considering these factors is crucial for safe and sustainable weight loss. Key findings indicate the importance of holistic approaches to weight management, including lifestyle modifications, medical interventions, and behavioral and psychological strategies. Effective weight loss strategies emphasize low-calorie, nutrient-rich diets, regular physical activity, and interventions tailored to individual needs. Combining multiple approaches offers the best chance of successful weight management and improved health outcomes.SummaryThis review provides insights into the complexities of obesity management and the factors contributing to the failure of weight loss programs. It highlights the necessity of adopting a holistic approach that addresses dietary habits, physical activity, genetic factors, psychological well-being, and socioeconomic influences. Recommendations include implementing lifestyle modifications, medical interventions when necessary, and integrating behavioral and psychological support to achieve sustainable weight loss and mitigate the global health challenge posed by obesity.
C1 [Khattab, Rabie] Imam Abdulrahman Bin Faisal Univ, Clin Nutr Dept, Dammam, Saudi Arabia.
C3 Imam Abdulrahman Bin Faisal University
RP Khattab, R (corresponding author), Imam Abdulrahman Bin Faisal Univ, Clin Nutr Dept, Dammam, Saudi Arabia.
EM rykhattab@iau.edu.sa
RI Khattab, Rabie/C-4990-2017
OI Khattab, Rabie/0000-0002-1715-970X
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   Yi Dae Yong, 2019, Korean J Pediatr, V62, P3, DOI 10.3345/kjp.2018.07360
   Zafar MI, 2019, AM J CLIN NUTR, V110, P891, DOI 10.1093/ajcn/nqz149
NR 191
TC 7
Z9 7
U1 7
U2 13
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
EI 2161-3311
J9 CURR NUTR REP
JI Curr. Nutr. Rep.
PD SEP
PY 2024
VL 13
IS 3
BP 478
EP 499
DI 10.1007/s13668-024-00551-x
EA JUN 2024
PG 22
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA C7R9F
UT WOS:001243822800001
PM 38861120
DA 2025-06-11
ER

PT J
AU Orlando, G
   Gervasi, R
   Luppino, IM
   Vitale, M
   Amato, B
   Silecchia, G
   Puzziello, A
AF Orlando, Giulio
   Gervasi, Rita
   Luppino, Ileana M.
   Vitale, Mario
   Amato, Bruno
   Silecchia, Gianfranco
   Puzziello, Alessandro
TI The role of a multidisciplinary approach in the choice of the best
   surgery approach in a super-super-obesity case
SO INTERNATIONAL JOURNAL OF SURGERY
LA English
DT Article
DE Super-super-obesity; Bariatric surgery; Multidisciplinary approach;
   Behavior therapy
ID BARIATRIC SURGERY; WEIGHT-LOSS; INTRAGASTRIC BALLOON; BILIOPANCREATIC
   DIVERSION; PSYCHOSOCIAL PREDICTORS; DUODENAL SWITCH; MEDICAL THERAPY;
   EFFICACY
AB Introduction: Obesity is a multifactorial chronic disease caused by a combination of hereditary, metabolic, dietary, cultural, social and psychological factors. Conservative treatments, such as diet and physical exercises, revealed a lack of long-term efficacy in patients with an extremely high BMI (>60 kg/m(2)).
   Methods: We present a multidisciplinary approach in a patient with an extremely high BMI: a twenty-one years old woman with a BMI 102 kg/m(2) (body weight 313 kg x height 175 cm) disabled to walk with severe depression and a psychological pattern of sweet eater and binge eating disorder. She was also amenorrheic and suffered from metabolic syndrome. The psychological assessment and the social-familial support were defined as priorities. Afterward, physical rehabilitation, behavior therapy, hypocaloric diet followed by intragastric balloon were planned as preoperative treatment. Finally a surgical program was scheduled: Sleeve Gastrectomy as first step of Biliopancreatic Diversion with Duodenal Switch.
   Results: Sixteenth months after the Sleeve Gastrectomy the weight was 130 kg (Excess Weight Loss = 74%) with a resumption of the menstrual cycle and a normalization of the metabolic syndrome.
   Conclusion: Due to the results obtained with both surgery and an excellent psychological supporting network we decided not to perform the expected Biliopancreatic Diversion with Duodenal Switch. The timing of bariatric surgery in superobesity patients is a milestone, but the cooperation among the specialists is essential for the choice of the best successful surgery. The multidisciplinary team should point to a comprehensive tailored management, considering motivation, compliance and adherence to a long-term follow-up as the keys for surgical success. (C) 2014 Surgical Associates Ltd. Published by Elsevier Ltd. All rights reserved.
C1 [Orlando, Giulio; Gervasi, Rita] Magna Graecia Univ Catanzaro, I-88100 Catanzaro, Italy.
   [Luppino, Ileana M.] Annunziata Hosp, Gastroenterol & Endoscopy Unit, I-87100 Cosenza, Italy.
   [Vitale, Mario; Puzziello, Alessandro] Univ Salerno, Dept Med & Surg, I-84084 Salerno, Italy.
   [Amato, Bruno] Univ Naples Federico II, Gen Surg Unit, I-80100 Naples, Italy.
   [Silecchia, Gianfranco] Univ Roma La Sapienza, Gen Surg Unit, I-00100 Rome, Italy.
   [Silecchia, Gianfranco] Univ Roma La Sapienza, Bariatr Ctr Excellence IFSO EC, Dept Med & Surg Biotechnol & Sci, I-00100 Rome, Italy.
C3 Magna Graecia University of Catanzaro; University of Salerno; University
   of Naples Federico II; Sapienza University Rome; Sapienza University
   Rome
RP Puzziello, A (corresponding author), Via Giuseppe Bonito 32, I-80129 Naples, Italy.
EM apuzziello@unisa.it
RI Amato, Bruno/AAS-7677-2020; puzziello, alessandro/AAS-1420-2021;
   Silecchia, Gianfranco/W-4878-2018
OI SILECCHIA, Gianfranco/0000-0003-2356-0505; Amato,
   Bruno/0000-0002-4262-8467; Puzziello, Alessandro/0000-0002-1970-7386;
   Gervasi, Rita/0000-0003-4395-2039
CR Andrade AM, 2010, PATIENT EDUC COUNS, V79, P320, DOI 10.1016/j.pec.2010.01.006
   Angrisani L, 2006, OBES SURG, V16, P1135, DOI 10.1381/096089206778392365
   Campanile FC, 2013, LANGENBECK ARCH SURG, V398, P669, DOI 10.1007/s00423-013-1077-2
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   Silecchia G, 2006, OBES SURG, V16, P1138, DOI 10.1381/096089206778392275
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   van Hout GCM, 2005, OBES SURG, V15, P552, DOI 10.1381/0960892053723484
NR 19
TC 17
Z9 18
U1 0
U2 11
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1743-9191
EI 1743-9159
J9 INT J SURG
JI Int. J. Surg.
PD AUG
PY 2014
VL 12
SU 1
BP S103
EP S106
DI 10.1016/j.ijsu.2014.05.037
PG 4
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA CB1AM
UT WOS:000349358800023
PM 24866068
OA Bronze
DA 2025-06-11
ER

PT J
AU Firth, J
   Carney, R
   Elliott, R
   French, P
   Parker, S
   McIntyre, R
   McPhee, JS
   Yung, AR
AF Firth, Joseph
   Carney, Rebekah
   Elliott, Rebecca
   French, Paul
   Parker, Sophie
   McIntyre, Rebecca
   McPhee, Jamie S.
   Yung, Alison R.
TI Exercise as an intervention for first-episode psychosis: a feasibility
   study
SO EARLY INTERVENTION IN PSYCHIATRY
LA English
DT Article
DE early intervention; exercise; physical activity; physical health;
   schizophrenia
ID INDUCED WEIGHT-GAIN; PHYSICAL-ACTIVITY; AEROBIC EXERCISE; METABOLIC
   SYNDROME; SCHIZOPHRENIA; FITNESS; NEUROCOGNITION; DISORDERS; ADULTS;
   METAANALYSIS
AB AimExercise can improve psychiatric symptoms, neurocognitive functioning and physical health in schizophrenia. However, the effects in early psychosis have not been explored. This study aimed to assess the feasibility of an exercise intervention for early psychosis and to determine if it was associated with changes in physical and mental health.
   MethodsThirty-one patients with first-episode psychosis (FEP) were recruited from early intervention services to a 10-week exercise intervention. The intervention group received individualized training programmes, aiming to achieve 90min of moderate-to-vigorous activity each week, using exercise programmes tailored to individual preferences and needs. A comparison FEP sample from the same services (n=7) received treatment as usual.
   ResultsRates of consent and retention in the exercise group were 94% and 81%, respectively. Participants achieved an average of 107min of moderate-to-vigorous exercise per week. Positive and Negative Syndrome Scale total scores reduced by 13.3 points after 10weeks of exercise, which was significantly greater than the treatment as usual comparison group (P=0.010). The greatest differences were observed in negative symptoms, which reduced by 33% in the intervention group (P=0.013). Significant improvements were also observed in psychosocial functioning and verbal short-term memory. Increases in cardiovascular fitness and processing speed were positively associated with the amounts of exercise achieved by participants.
   ConclusionIndividualized exercise training could provide a feasible treatment option for improving symptomatic, neurocognitive and metabolic outcomes in FEP.
C1 [Firth, Joseph; Carney, Rebekah; Elliott, Rebecca; Yung, Alison R.] Univ Manchester, Inst Brain Behav & Mental Hlth, Room 3-306,Jean McFarlane Bldg,Oxford Rd, Manchester M13 9PL, Lancs, England.
   [Elliott, Rebecca] Univ Manchester, Manchester Acad Hlth Sci Ctr, Manchester, Lancs, England.
   [Parker, Sophie] Univ Manchester, Sch Psychol Sci, Manchester, Lancs, England.
   [French, Paul; Parker, Sophie; Yung, Alison R.] Manchester Metropolitan Univ, Greater Manchester West NHS Mental Hlth Fdn Trust, Manchester, Lancs, England.
   [McPhee, Jamie S.] Manchester Metropolitan Univ, Sch Healthcare Sci, Manchester, Lancs, England.
   [French, Paul] Univ Liverpool, Dept Psychol Sci, Liverpool, Merseyside, England.
   [McIntyre, Rebecca] Lincolnshire Partnership NHS Fdn Trust, Sleaford, Lincs, England.
C3 University of Manchester; University of Manchester; University of
   Manchester; Manchester Metropolitan University; Manchester Metropolitan
   University; University of Liverpool
RP Firth, J (corresponding author), Univ Manchester, Inst Brain Behav & Mental Hlth, Room 3-306,Jean McFarlane Bldg,Oxford Rd, Manchester M13 9PL, Lancs, England.
EM joseph.firth@postgrad.manchester.ac.uk
RI Carney, Rebekah/AAO-5205-2021; Firth, Joseph/JOZ-1679-2023; Yung,
   Alison/N-6729-2019
OI Parker, Sophie/0000-0001-5596-7524; Yung, Alison/0000-0002-0401-9791;
   McPhee, Jamie/0000-0002-3659-0773; French, Paul/0000-0003-4300-387X;
   Elliott, Rebecca/0000-0002-7602-010X; Carney,
   Rebekah/0000-0002-2859-6825
FU Greater Manchester West Mental Health NHS Foundation Trust; MRC Doctoral
   Training Grant
FX The study was funded by Greater Manchester West Mental Health NHS
   Foundation Trust. Corresponding author JF is supported by an MRC
   Doctoral Training Grant. We acknowledge the contributions of the Early
   Intervention Services in Bolton, Salford and Trafford for their
   continued support throughout the project.
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   [No title captured]
NR 55
TC 85
Z9 86
U1 1
U2 26
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1751-7885
EI 1751-7893
J9 EARLY INTERV PSYCHIA
JI Early Interv. Psychiatry
PD JUN
PY 2018
VL 12
IS 3
BP 307
EP 315
DI 10.1111/eip.12329
PG 9
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA GI0WG
UT WOS:000434090500004
PM 26987871
OA Green Published, hybrid, Green Accepted
DA 2025-06-11
ER

PT J
AU do Couto, FS
   Queiroz, C
   Barbosa, T
   Ferreira, L
   Firmino, H
   Viseu, M
   Ramos, L
   Romero, J
   Figuera, M
AF do Couto, Frederico Simoes
   Queiroz, Cristina
   Barbosa, Teresa
   Ferreira, Luis
   Firmino, Horacio
   Viseu, Miguel
   Ramos, Luisa
   Romero, Jose
   Figuera, MariaLuisa
CA Grp Estudio ACORDARE
TI Clinical and therapeutic characterization of a portuguese sample of
   patients with schizophrenia
SO ACTAS ESPANOLAS DE PSIQUIATRIA
LA English
DT Article
DE Schizophrenia; Portugal; epidemiology; therapeutics; demography
ID ANTIPSYCHOTIC-DRUGS; METABOLIC SYNDROME; PATTERNS
AB Introduction. The development of Mental Health policies for psychiatric disorders should be driven by a correct knowledge of the socio-demographic, clinical and therapeutic realities of the disease. There is paucity of detailed studies in the Portuguese population that does not allow a direct comparation with other European countries. The objective of the present study is to characterize the sociodemograhic and clinical characteristics of schizophrenia patients in Portugal and the therapeutic patterns.
   Methods. This multicentric, cross sectional, non interventional study was designed to describe the demographic and clinical data of patients with schizophrenia (n=474), and also the demographic and professional characteristics of their treating psychiatrists.
   Results. The most frequent diagnosis found was paranoid schizophrenia (54%), with comorbid psychiatric conditions in 39,7% arid somatic diseases in 28.4% of the patients. About half the patients were on second generation antipsychotics (SGS) as principal therapy, although haloperidol has been the most frequent drug prescribed as so (35.9 %). 59.51 % of the patients were on antipsychotic monotherapy, and 45% on a depot formulation. Antipsychotic dose vary widely, and they are quite often prescribed on off label doses.
   Discussion. Our sample is similar to others found in naturalistic studies, however slightly different from clinical trials. In general, patients with schizophrenia tend to be treated with SGA, although have a higher chance to be on a long-term formulation and to be on polytherapy than in other studies. Somatic diseases are maybe under diagnosed and are undertreated.
C1 [do Couto, Frederico Simoes] Fac Med Lisbon, Lab Psicol Piso 6, Clin Univ Psiquiatria, P-1649028 Lisbon, Portugal.
   [do Couto, Frederico Simoes] Inst Mol Med, Inst Farmacol & Neurociencias, Lisbon, Portugal.
   [Queiroz, Cristina] Bristol Meyers Squibb, Dept Med, Lisbon, Portugal.
   [Firmino, Horacio] Hosp Univ Coimbra, Coimbra, Portugal.
   [Barbosa, Teresa] Hosp Amato Lusitano, Viseu, Portugal.
   [Viseu, Miguel] Hosp Sao Pedro, Vila Real, Portugal.
   [Ferreira, Luis] Hosp Magalhaes Lemos, Oporto, Portugal.
   [Ramos, Luisa; Romero, Jose] Ctr Hosp Conde Ferreira, Oporto, Portugal.
C3 Universidade de Lisboa; Universidade de Lisboa; Universidade de Coimbra;
   Centro Hospitalar e Universitario de Coimbra (CHUC)
RP do Couto, FS (corresponding author), Fac Med Lisbon, Lab Psicol Piso 6, Clin Univ Psiquiatria, Av Prof Egas Moniz, P-1649028 Lisbon, Portugal.
EM fcouto@fm.ut.pt
RI Romero, Jose/KIE-0532-2024; PALHA, ANTONIO/B-1873-2015; Simoes do Couto,
   Frederico/J-9374-2017
OI PALHA, ANTONIO/0000-0003-1619-0040; Simoes do Couto,
   Frederico/0000-0002-3916-2598; Figueira, Maria Luisa/0000-0002-7921-5375
CR Ashcroft DM, 2002, PHARMACOEPIDEM DR S, V11, P285, DOI 10.1002/pds.703
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   Bento A., 2003, Saude em Numeros, V16, P12
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NR 18
TC 2
Z9 4
U1 0
U2 3
PU JUAN JOSE LOPEZ-IBOR FOUNDATION
PI MADRID
PA NO 2, MADRID, 28035, SPAIN
SN 1139-9287
EI 1578-2735
J9 ACTAS ESP PSIQUIATRI
JI Actas Esp. Psiquiatri.
PD MAY-JUN
PY 2011
VL 39
IS 3
BP 147
EP 154
PG 8
WC Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Psychiatry
GA 851AH
UT WOS:000297240200001
PM 21560074
DA 2025-06-11
ER

PT J
AU Montesinos-Ruedal, L
   Canete-Crespillo, J
   Palma-Sevillano, C
   Giné-Serven, E
AF Montesinos-Ruedal, Laura
   Canete-Crespillo, Josep
   Palma-Sevillano, Carolina
   Gine-Serven, Eloi
TI Erythrocyte membrane polyunsaturated fatty acid (PUFA) levels in a
   sample of patients with schizophrenia and relation with clinical and
   progression variables
SO ACTAS ESPANOLAS DE PSIQUIATRIA
LA English
DT Article
DE Schizophrenia; Omega-3 polyunsaturated fatty acids; Erythrocyte
   membranes
ID SCALE; VALIDATION
AB Introduction. Previous studies have shown that erythrocyte cell membranes in patients with schizophrenia contain considerably less omega-3 fatty acids, particularly EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid), reflecting the lower levels present in neuronal and central nervous system membranes. This phenomenon, linked to genetic, metabolic, or dietary factors, has been associated with the development of schizophrenia and the risk of developing and the severity of metabolic syndrome.
   Methods. This study is an observational study conducted in a sample of 31 patients with schizophrenia treated at the Mataro Mental Health Center (Barcelona). Its aim was to relate the erythrocyte levels of omega 3 with the clinical severity of schizophrenia and dietary habits.
   EPA (eicosapentaenoic acid), DHA (docosahexaenoic acid) and other membrane lipid levels were determined, as well as psychopathology, cognitive, and social functioning measures, previous evolution, and finally a survey of dietary habits.
   Results. Our results did not show a statistically significant correlation between erythrocyte omega-3 levels and psychopathological and clinical severity variables. Higher, statistically significant, levels were found in the group of women and in subjects with more days of admission to the day hospital. In contrast, lower values were obtained in subjects treated with long-acting antipsychotics and in sunflower oil consumers.
   Conclusions. Despite not being able to demonstrate our working hypothesis, significant correlations were found that were consistent with published findings in the current literature. The need for studies with larger samples and groups of healthy controls is postulated.
C1 [Montesinos-Ruedal, Laura; Canete-Crespillo, Josep; Palma-Sevillano, Carolina; Gine-Serven, Eloi] Consorci Sanitari Maresme, Hosp Mataro, Salud Mental & Adicc, Barcelona, Spain.
RP Montesinos-Ruedal, L (corresponding author), Carretera Cirera S-N, Mataro 08304, Barcelona, Spain.
EM montesinos.rueda@gmail.com
RI Gine Serven, Eloi/KLZ-4634-2024; CANETE, JOSE/H-6715-2014; Palma,
   Carol/G-6944-2017
OI CANETE, JOSE/0000-0002-1368-6801; Palma, Carol/0000-0001-5371-7417
FU Catalonian Agency for the Assessment of Health Technology and Research
   [091/20/2006]
FX This study is part of the project funded by the Catalonian Agency for
   the Assessment of Health Technology and Research No. 091/20/2006 titled
   "Assaig clinic sobre dels acids grassos poliinsaturats (PUFA) en la
   millora clinica i la prevencio de la sindrome metabolica en malalts
   esquizofrenics [Clinical Trial on the Efficacy of Polyunsaturated Fatty
   Acids (PUFA) in the Clinical Improvement and Prevention of Metabolic
   Syndrome in Schizophrenic Disorders]." Principal Investigator Josep
   Canete. Consorci Sanitari del Maresme.
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   [Anonymous], 2003, ABNORMALITIES FATTY
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NR 29
TC 10
Z9 10
U1 0
U2 10
PU JUAN JOSE LOPEZ-IBOR FOUNDATION
PI MADRID
PA NO 2, MADRID, 28035, SPAIN
SN 1139-9287
EI 1578-2735
J9 ACTAS ESP PSIQUIATRI
JI Actas Esp. Psiquiatri.
PD SEP-OCT
PY 2015
VL 43
IS 5
BP 170
EP 176
PG 7
WC Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Psychiatry
GA CR4XR
UT WOS:000361343900002
PM 26320895
DA 2025-06-11
ER

PT J
AU Sanz, CM
   Ruidavets, JB
   Bongard, V
   Marquié, JC
   Hanaire, H
   Ferrières, J
   Andrieu, S
AF Sanz, Caroline M.
   Ruidavets, Jean-Bernard
   Bongard, Vanina
   Marquie, Jean-Claude
   Hanaire, Helene
   Ferrieres, Jean
   Andrieu, Sandrine
TI Relationship Between Markers of Insulin Resistance, Markers of
   Adiposity, HbA1c, and Cognitive Functions in a Middle-Aged
   Population-Based Sample: the MONA LISA Study
SO DIABETES CARE
LA English
DT Article
ID ATHEROSCLEROSIS RISK; METABOLIC SYNDROME; FOLLOW-UP; DEMENTIA;
   ASSOCIATION; DISEASE; PREVALENCE; PREVENTION; OBESITY; INDEX
AB OBJECTIVE-To determine the relationship between markers of insulin resistance (fasting insulin and homeostasis model assessment of insulin resistance), markers of adiposity (BMI, waist circumference, and body fat), HbA(1c), and cognitive performances in a middle-aged population based sample free of diabetes.
   RESEARCH DESIGN AND METHODS-Our study sample consisted of 1,172 people aged 35-64 years (49% women), free of diabetes, and recruited between 2005 and 2007 in the MONA LISA survey. Cognitive functions (memory, attention, and processing speed) were evaluated by neuropsychological tests: word-list learning test, digit symbol substitution test (DSST), word fluency test, and Stroop Test. Multiple logistic regressions were used to estimate the relationship between cognitive performance and metabolic markers. We serially adjusted for age, sex, education, and occupational status (model A), additionally for income, smoking, alcohol consumption, sedentarity, and psychotropic substance use (model B), and finally, included variables linked to the metabolic syndrome (hypertension, dyslipidemia, vascular disease, and C-reactive protein) and depression (model C).
   RESULTS-Elevated markers of adiposity were associated with poor cognitive performance in tests evaluating processing speed. The probability of being in the lowest quartile of each test was nearly doubled for participants in the upper quartile of BMI, compared with those in the lowest one [BMI, adjusted odds ratio (OR) 2.18, P = 0.003 (DSST), and OR 2.09, P = 0.005 (Stroop Test)]. High HbA(1c) was associated with poor cognitive performance in DSST (adjusted OR 1.75, P = 0.037). Waist circumference was linked to poor cognitive performance in men but not in women.
   CONCLUSIONS-Poor cognitive performance is associated with adiposity and hyperglycemia in healthy middle-aged people.
C1 [Sanz, Caroline M.; Ruidavets, Jean-Bernard; Bongard, Vanina; Ferrieres, Jean; Andrieu, Sandrine] Univ Toulouse 3, INSERM, UMR 1027, F-31062 Toulouse, France.
   [Sanz, Caroline M.; Hanaire, Helene] Toulouse Univ Hosp, Dept Diabetol Metab Dis & Nutr, Toulouse, France.
   [Ruidavets, Jean-Bernard; Bongard, Vanina; Ferrieres, Jean; Andrieu, Sandrine] Toulouse Univ Hosp, Dept Epidemiol & Publ Hlth, Toulouse, France.
   [Marquie, Jean-Claude] Univ Toulouse 2, UMR CNRS EPHE 5263, Toulouse, France.
   [Ferrieres, Jean] Toulouse Univ Hosp, Dept Cardiol B, Toulouse, France.
   [Andrieu, Sandrine] Toulouse Univ Hosp, Dept Geriatr Med, Toulouse, France.
C3 Institut National de la Sante et de la Recherche Medicale (Inserm);
   Universite de Toulouse; Universite Toulouse III - Paul Sabatier;
   Universite de Toulouse; Universite Toulouse III - Paul Sabatier; CHU de
   Toulouse; Universite de Toulouse; Universite Toulouse III - Paul
   Sabatier; CHU de Toulouse; Universite de Toulouse; Universite de
   Toulouse - Jean Jaures; Universite de Toulouse; Universite Toulouse III
   - Paul Sabatier; CHU de Toulouse; CHU de Toulouse; Universite de
   Toulouse; Universite Toulouse III - Paul Sabatier
RP Ruidavets, JB (corresponding author), Univ Toulouse 3, INSERM, UMR 1027, F-31062 Toulouse, France.
EM jean-bernard.ruidavets@cict.fr
RI Bongard, Vanina/KLY-9335-2024; ANDRIEU, Sandrine/G-1343-2018; Ferrieres,
   Jean/S-7993-2016
OI Ferrieres, Jean/0000-0001-6144-1297; Bongard, Vanina/0000-0001-5789-0815
FU Agence Nationale de la Recherche [ANR-05-PNRA-018]; Institut National de
   Veille Sanitaire; INSERM; Pfizer; Toulouse University Hospital
FX The MONA LISA study was supported by a grant from the Agence Nationale
   de la Recherche (ANR-05-PNRA-018), the Institut National de Veille
   Sanitaire, INSERM, and a grant from Pfizer. This study was also
   supported by a grant for young researchers from the Toulouse University
   Hospital. The sponsors of the study had no role in study design, data
   collection, data analysis, data interpretation, or writing of the
   manuscript. No other potential conflicts of interest relevant to this
   article were reported.
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NR 36
TC 48
Z9 52
U1 0
U2 18
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0149-5992
EI 1935-5548
J9 DIABETES CARE
JI Diabetes Care
PD JUN
PY 2013
VL 36
IS 6
BP 1512
EP 1521
DI 10.2337/dc12-1017
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 178UJ
UT WOS:000321472600014
PM 23275371
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Cohen, H
   Kozlovsky, N
   Savion, N
   Matar, MA
   Loewenthal, U
   Loewenthal, N
   Zohar, J
   Kaplan, Z
AF Cohen, H.
   Kozlovsky, N.
   Savion, N.
   Matar, M. A.
   Loewenthal, U.
   Loewenthal, N.
   Zohar, J.
   Kaplan, Z.
TI An Association Between Stress-Induced Disruption of the
   Hypothalamic-Pituitary-Adrenal Axis and Disordered Glucose Metabolism in
   an Animal Model of Post-Traumatic Stress Disorder
SO JOURNAL OF NEUROENDOCRINOLOGY
LA English
DT Article
DE animal model; post-traumatic stress disorder; metabolic syndrome;
   glucose homeostasis; insulin; corticosterone; insulin receptor; GLUT4
ID CHRONIC RESTRAINT STRESS; RAT HIPPOCAMPUS; INSULIN-RESISTANCE;
   DIABETES-MELLITUS; PRIMARY-CARE; OBESITY; CORTICOSTERONE; SECRETION;
   TRAUMA; GLUCOCORTICOIDS
AB Retrospective clinical reports suggesting that traumatic stress populations display an increased propensity for glucose metabolism disorders were examined in a controlled prospective animal model. Stress-induced behavioural and hypothalamic-pituitary-adrenal (HPA) axis response patterns were correlated to central and peripheral parameters of glucose metabolism and signalling, and to body measurements in Sprague-Dawley rats exposed to predator scent stress. Forty days post-exposure, fasting blood glucose and insulin levels, oral glucose tolerance test, body weight and white adipose tissue mass, systemic corticosterone levels and brain expression of insulin receptor (IR) and insulin-sensitive glucose transporter 4 (GLUT4) protein levels were evaluated. In a second experiment inbred strains with hyper- (Fischer) and hypo- (Lewis) reactive HPA axes were employed to assess the association of metabolic data with behavioural phenomenology versus HPA axis response profile. For data analysis, animals were classified according to their individual behavioural response patterns (assessed at day 7) into extreme, partial and minimal response groups. The exposed Sprague-Dawley rats fulfilling criteria for extreme behavioural response (EBR) (20.55%) also exhibited significant increases in body weight, abdominal circumference and abdominal white adipose tissue mass; a hyperglycaemic oral glucose tolerance test; and fasting hyperglycaemia, hyperinsulinaemia and hypercorticosteronemia, whereas minimal responders (MBR) and control animals displayed no such disturbances. Hippocampal and hypothalamic expression of IR and GLUT4 protein were significantly lower in EBR than in MBR and control rats. The inbred strains showed no metabolic differences at baseline. Exposed Fischer rats displayed hyperglycaemia and hyperinsulinaemia, whereas Lewis rats did not. A significant protracted disorder of glucose metabolism was induced by exposure to a stress paradigm. This metabolic response was associated with the characteristic pattern of HPA axis (corticosterone) response, which underlies the behavioural response to stress.
C1 [Cohen, H.; Kozlovsky, N.; Savion, N.; Matar, M. A.; Loewenthal, U.; Kaplan, Z.] Ben Gurion Univ Negev, Fac Hlth Sci,State Israel Minist Hlth, Anxiety & Stress Res Unit, Beer Sheva Mental Hlth Ctr, IL-84170 Beer Sheva, Israel.
   [Loewenthal, N.] Ben Gurion Univ Negev, Fac Hlth Sci, Div Pediat, IL-84170 Beer Sheva, Israel.
   [Zohar, J.] Tel Aviv Univ, Sackler Sch Med, Chaim Sheba Med Ctr, Div Psychiat,State Israel Minist Hlth, Ramat Gan, Israel.
C3 Ben-Gurion University of the Negev; Ministry of Health - Israel;
   Ben-Gurion University of the Negev; Chaim Sheba Medical Center; Tel Aviv
   University; Sackler Faculty of Medicine; Ministry of Health - Israel
RP Cohen, H (corresponding author), Ben Gurion Univ Negev, Fac Hlth Sci, Mental Hlth Ctr, Anxiety & Stress Res Unit,Minist Hlth, POB 4600, IL-84170 Beer Sheva, Israel.
EM hagitc@bgu.ac.il
RI KOZLOVSKY, NITZAN/F-2041-2012
OI Cohen, Hagit/0000-0002-4762-1969
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NR 47
TC 26
Z9 29
U1 0
U2 9
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0953-8194
EI 1365-2826
J9 J NEUROENDOCRINOL
JI J. Neuroendocrinol.
PD NOV
PY 2009
VL 21
IS 11
BP 898
EP 909
DI 10.1111/j.1365-2826.2009.01913.x
PG 12
WC Endocrinology & Metabolism; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Neurosciences & Neurology
GA 509QD
UT WOS:000271032200004
PM 19732290
DA 2025-06-11
ER

PT J
AU Rosenbaum, S
   Nijjar, S
   Watkins, A
   Garwood, N
   Sherrington, C
   Tiedemann, A
AF Rosenbaum, Simon
   Nijjar, Sukh
   Watkins, Andrew
   Garwood, Natasha
   Sherrington, Catherine
   Tiedemann, Anne
TI Nurse-assessed metabolic monitoring: A file audit of risk factor
   prevalence and impact of an intervention to enhance measurement of waist
   circumference
SO INTERNATIONAL JOURNAL OF MENTAL HEALTH NURSING
LA English
DT Article
DE psychiatry; metabolic syndrome; anthropometry; nursing; audit
ID SERIOUS MENTAL-ILLNESS; RANDOMIZED CONTROLLED-TRIAL; INSULIN-RESISTANCE;
   WEIGHT-GAIN; SCHIZOPHRENIA; MORTALITY; HEALTH; CLOZAPINE; PROGRAM;
   OBESITY
AB The aim of the present study was to: (i) document the prevalence of risk factors for non-communicable diseases among mental health consumers (inpatients) with various diagnoses; and (ii) audit the frequency of waist circumference (WC) documentation before and after an intervention that involved a single nurse-education session, and change in assessment-form design. The study was undertaken in a private psychiatric hospital in Sydney, Australia. Twenty-five nurses participated in the educational intervention. File audits were performed prior to intervention delivery (n = 60), and 3 months' (n = 60), and 9 months' (n = 60) post-intervention. Files were randomly selected, and demographic (age, diagnosis) and risk factor (WC, body mass index (BMI), smoking status, blood pressure) data were extracted. WC was higher in this cohort compared to published general population means, and only 19% of patients had a BMI within the healthy range. In total, 37% of patients smoked, while 31% were hypertensive. At baseline, none of the audited files reported WC, which increased to 35 of the 60 (58%) files audited at the 3-month follow up. At the 9-month follow up, 25 of the 60 (42%) files audited reported a WC. In the 120 post-intervention files audited, only two patients refused measurement. These results illustrate the poor physical health of inpatients, and suggest that nurse-assessed metabolic monitoring can be enhanced with minimal training.
C1 [Rosenbaum, Simon; Sherrington, Catherine; Tiedemann, Anne] Univ Sydney, George Inst Global Hlth, Sydney Med Sch, Sydney, NSW 2006, Australia.
   [Rosenbaum, Simon; Nijjar, Sukh; Garwood, Natasha] Richmond Hosp, St John God Hlth Care, Sydney, NSW, Australia.
   [Watkins, Andrew] South Eastern Sydney Local Hlth Dist, Mental Hlth Serv, Sydney, NSW, Australia.
C3 University of Sydney; George Institute for Global Health; St John of God
   Health Care; South Eastern Sydney Local Health District
RP Rosenbaum, S (corresponding author), George Inst Global Hlth, POB M201 Missenden Rd, Camperdown, NSW 2050, Australia.
EM srosenbaum@georgeinstitute.org.au
RI Sherrington, Cathie/S-9196-2019; Tiedemann, Anne/AFB-4211-2022;
   Rosenbaum, Simon/Y-3241-2019
OI Watkins, Andrew/0000-0003-3452-8682; Rosenbaum,
   Simon/0000-0002-8984-4941; Sherrington, Catherine/0000-0001-8934-4368
FU St John of God Health Care, Richmond Hospital; National Health and
   Medical Research Council of Australia
FX The authors would like to acknowledge the staff of the Xavier Unit, St
   John of God Health Care, Richmond Hospital, for their assistance with
   this study. Mr Simon Rosenbaum was funded by St John of God Health Care,
   Richmond Hospital. Professor Cathie Sherrington holds a Senior Research
   Fellowship, and Dr Anne Tiedemann holds a Research Training Fellowship
   granted by the National Health and Medical Research Council of
   Australia.
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NR 28
TC 23
Z9 26
U1 1
U2 13
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1445-8330
EI 1447-0349
J9 INT J MENT HEALTH NU
JI Int. J. Ment. Health Nurs.
PD JUN
PY 2014
VL 23
IS 3
BP 252
EP 256
DI 10.1111/inm.12057
PG 5
WC Nursing; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Psychiatry
GA AE6SE
UT WOS:000334124000008
PM 24393271
DA 2025-06-11
ER

PT J
AU Morita, R
   Arakida, M
   Osborne, RH
   Nolte, S
   Elsworth, GR
   Mikami, H
AF Morita, Rie
   Arakida, Mikako
   Osborne, Richard H.
   Nolte, Sandra
   Elsworth, Gerald R.
   Mikami, Hiroshi
TI Adaptation and validation of the Japanese version of the Health
   Education Impact Questionnaire (heiQ-J) for the evaluation of
   self-management education interventions
SO JAPAN JOURNAL OF NURSING SCIENCE
LA English
DT Article
DE program evaluation; reliability; self-management; translation and
   cultural adaptation; validity
ID CHRONIC DISEASE; PROGRAMS; OUTCOMES; SUPPORT; PEOPLE
AB Aim: In many countries, health education interventions are popular; however, few valid measures exist for evaluation of multifactorial interventions. The aim of the present study was to translate and culturally adapt the widely-used 8 scale Health Education Impact Questionnaire (heiQ) for the evaluation of the Japanese Specific Health Consultation (SHC) in people with metabolic syndrome. Methods: A draft was generated using a standardized forward and back translation protocol with independent translators and consensus meetings. Pilot testing included cognitive interviews (n=12) resulting in question refinements. To explore psychometric properties, 250 participants aged between 40 and 64years (retest=116) completed the Japanese version of the heiQ (heiQ-J) and comparator scales, mental health and vitality scales of the Medical Outcomes Study 36 item Short-Form Health Survey, Sense Of Coherence scale, and Social Support Measurement scale. Results: Cognitive interviews revealed that the translation was understood as intended by participants. Internal consistency () was good to very good for all scales (0.70-0.88) and test-retest intraclass correlation coefficients were high (0.83). Concurrent validity was supported by high correlation with like scales and weak correlation with dissimilar scales. Conclusion: The translated and adapted heiQ-J has good face and concurrent validity and is reliable. The heiQ-J is likely to be a useful measure of the quality and impact of the SHC and return valuable data to clinicians and commissioners of health education in Japan.
C1 [Morita, Rie; Mikami, Hiroshi] Osaka Univ, Div Hlth Sci, Grad Sch Med, Suita, Osaka, Japan.
   [Arakida, Mikako] Int Univ Hlth & Welf, Sch Nursing & Rehabil Sci Odawara, Odawara, Kanagawa, Japan.
   [Osborne, Richard H.; Nolte, Sandra; Elsworth, Gerald R.] Deakin Univ, Populat Hlth Strateg Res Ctr, Melbourne, Vic, Australia.
C3 The University of Osaka; International University of Health & Welfare;
   Deakin University
RP Morita, R (corresponding author), Osaka Univ, Div Hlth Sci, Grad Sch Med, Suita, Osaka, Japan.
EM rierie5@sahs.med.osaka-u.ac.jp
RI Nolte, Sandra/B-7498-2008; Osborne, Richard/A-9447-2010
OI Nolte, Sandra/0000-0001-6185-9423; Osborne, Richard/0000-0002-9081-2699
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NR 29
TC 19
Z9 21
U1 0
U2 17
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-7932
EI 1742-7924
J9 JPN J NURS SCI
JI Jpn. J. Nurs. Sci.
PD DEC
PY 2013
VL 10
IS 2
BP 255
EP 266
DI 10.1111/j.1742-7924.2012.00224.x
PG 12
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA 278RJ
UT WOS:000328907100015
PM 24373448
DA 2025-06-11
ER

PT J
AU Arakelian, E
   Paulsson, S
   Molin, F
   Svartengren, M
AF Arakelian, Erebouni
   Paulsson, Sofia
   Molin, Fredrik
   Svartengren, Magnus
TI How Human Resources Index, Relational Justice, and Perceived
   Productivity Change after Reorganization at a Hospital in Sweden That
   Uses a Structured Support Model for Systematic Work Environment
   Management
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Article
DE hospital setting; work environment; intervention; participative;
   productivity
ID ORGANIZATIONAL JUSTICE; METABOLIC SYNDROME; SLEEPING PROBLEMS;
   MENTAL-HEALTH; EMPLOYEES; INTERVENTIONS; BEHAVIORS; DEMANDS; DISEASE;
   STRAIN
AB To facilitate systematic work environment management, which should be a natural part of business development, a structured support model was developed. The Stamina model has previously been used in Swedish municipalities, showing positive results. The aim was to study how the Human Resources Index (HRI), relational justice, short-term recovery and perceived productivity changed in a recently reorganised perioperative setting in a hospital in Sweden that uses a structured support model for systematic work environment management. A longitudinal design that took measurements at four time points was used in a sample of 500 employees in a perioperative hospital department. The results for the overall sample indicated a positive trend in the HRI (Mt1 = 48.5, SDt1 = 22.5; Mt3 = 56.7, SDt1 = 21.2; p < 0.001). Perceived health-related production loss (Mdt1 = 2, IQR = 3; Mdt3 = 0, IQR = 3; p < 0.001) and perceived work environment-related production loss (Mdt1 = 2, IQR = 3; Mdt3 = 0, IQR = 4; p < 0.001) showed major improvements. Short-term recovery showed a minor improvement (Mt1 = 2.61, SDt1 = 1.33; Mt3 = 2.65, SDt3 = 1.22; p = 0.872). In conclusion, the implementation of the Stamina model, of which the HRI constitutes an important part, seems to be a helpful tool to follow-up on work environment processes, and minimise production losses due to health and work environment-related issues.
C1 [Arakelian, Erebouni] Uppsala Univ, Dept Surg Sci, S-75237 Uppsala, Sweden.
   [Paulsson, Sofia; Molin, Fredrik; Svartengren, Magnus] Uppsala Univ, Dept Med Sci Occupat & Environm Med, S-75237 Uppsala, Sweden.
   [Molin, Fredrik] Uppsala Univ, Inst Org & Leadership Dev, IPF, S-75320 Uppsala, Sweden.
C3 Uppsala University; Uppsala University; Uppsala University
RP Arakelian, E (corresponding author), Uppsala Univ, Dept Surg Sci, S-75237 Uppsala, Sweden.
EM erebouni.arakelian@surgsci.uu.se; Sofia.Paulsson@hpihealth.se;
   fredrik.molin@ipf.se; magnus.svartengren@medsci.uu.se
RI Svartengren, Magnus/AAM-7777-2021
OI Arakelian, Erebouni/0000-0003-3790-3505; Svartengren,
   Magnus/0000-0002-8165-7236
FU AFA Insurance [160271]; University Hospital (ALF), Uppsala, Sweden
FX AFA Insurance (grant number: 160271) and the regional agreement on
   medical training and clinical research between Uppsala University and
   University Hospital (ALF), Uppsala, Sweden.
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NR 62
TC 3
Z9 3
U1 0
U2 9
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD NOV
PY 2021
VL 18
IS 21
AR 11611
DI 10.3390/ijerph182111611
PG 15
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA XJ7UB
UT WOS:000726986800001
PM 34770126
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Brenjian, S
   Moini, A
   Yamini, N
   Kashani, L
   Faridmojtahedi, M
   Bahramrezaie, M
   Khodarahmian, M
   Amidi, F
AF Brenjian, Samaneh
   Moini, Ashraf
   Yamini, Nazila
   Kashani, Ladan
   Faridmojtahedi, Maryam
   Bahramrezaie, Mojdeh
   Khodarahmian, Mahshad
   Amidi, Fardin
TI Resveratrol treatment in patients with polycystic ovary syndrome
   decreased pro-inflammatory and endoplasmic reticulum stress markers
SO AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
LA English
DT Article
DE endoplasmic reticulum stress; inflammation; polycystic ovary syndrome;
   resveratrol
ID FACTOR-KAPPA-B; C-REACTIVE PROTEIN; ER STRESS; INSULIN-RESISTANCE;
   METABOLIC SYNDROME; OXIDATIVE STRESS; GRANULOSA-CELLS; APOPTOSIS;
   ACTIVATION; WOMEN
AB Problem Polycystic ovary syndrome (PCOS) is associated with endoplasmic reticulum (ER) stress and pro-inflammatory condition. The aim of the present study was to evaluate the effect of resveratrol treatment on pro-inflammatory and ER stress markers in patients with PCOS. Method of study Cumulus cells were obtained from 40 patients with PCOS who were divided into two groups: placebo and resveratrol treatment (receiving 800 mg/d for 40 days) groups. Blood samples were obtained from all patients before and after the procedure to evaluate interleukin (IL)-6, IL-1 beta, IL-18, TNF-alpha, NF-kappa B, and C-reactive protein (CRP). Total RNA was extracted from cumulus cells, and cDNA was synthesized by reverse transcription. Expressions of five genes in ER stress response pathway (ATF4, ATF6, CHOP, GRP78, and XBP1s) were assessed with quantitative real-time PCR. Statistical analysis was performed with Student's t test. Results After treatment with resveratrol, it was found that serum levels of IL-6, IL-1 beta, TNF-alpha, IL-18, NF-kappa B, and CRP decreased in the treatment group. In addition, gene expression results showed that the expression levels of ATF4 (P < .05) and ATF6 (P < .001) significantly increased in the resveratrol treatment group, while the expression levels of CHOP, GRP78, and XBP1 (P < .001 for all) significantly decreased. Conclusion Results demonstrated that resveratrol has anti-inflammatory effects through the suppression of NF-kappa B and NF-kappa B-regulated gene products. On the other hand, resveratrol can modulate ER stress in granulosa cells (GCs) by altering the expression of genes involved in unfolding protein response (UPR) process. Our findings suggest that ER stress is a potential therapeutic target for patients with PCOS.
C1 [Brenjian, Samaneh; Bahramrezaie, Mojdeh; Khodarahmian, Mahshad; Amidi, Fardin] Univ Tehran Med Sci, Sch Med, Dept Anat, 16 Azar Ave,Poor Sina St, Tehran, Iran.
   [Moini, Ashraf; Kashani, Ladan; Faridmojtahedi, Maryam] Univ Tehran Med Sci, Sch Med, Dept Gynecol & Obstet, Tehran, Iran.
   [Moini, Ashraf] ACECR, Royan Inst Reprod Biomed, Dept Endocrinol & Female Infertil, Reprod Biomed Res Ctr, Tehran, Iran.
   [Moini, Ashraf] Univ Tehran Med Sci, Vall E Asr Reprod Hlth Res Ctr, Tehran, Iran.
   [Yamini, Nazila] Univ Tehran Med Sci, Arash Womens Hosp, Dept ART, Embryol Lab, Tehran, Iran.
   [Amidi, Fardin] Univ Tehran Med Sci, Shariati Hosp, Dept Infertil, Tehran, Iran.
C3 Tehran University of Medical Sciences; Tehran University of Medical
   Sciences; Academic Center for Education, Culture & Research (ACECR);
   Tehran University of Medical Sciences; Tehran University of Medical
   Sciences; Tehran University of Medical Sciences
RP Amidi, F (corresponding author), Univ Tehran Med Sci, Sch Med, Dept Anat, 16 Azar Ave,Poor Sina St, Tehran, Iran.; Amidi, F (corresponding author), Univ Tehran Med Sci, Shariati Hosp, Dept Infertil, Tehran, Iran.
EM Famidi@sina.tums.ac.ir
RI moini, Ashraf/AAR-4071-2020; AMIN, LADAN/C-8041-2011; brenjian,
   samaneh/AAA-2091-2021
FU Tehran University of Medical Sciences and Health Services
   [94-03-30-29803]
FX Tehran University of Medical Sciences and Health Services, Grant/Award
   Number: 94-03-30-29803
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NR 50
TC 81
Z9 91
U1 2
U2 26
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1046-7408
EI 1600-0897
J9 AM J REPROD IMMUNOL
JI Am. J. Reprod. Immunol.
PD JAN
PY 2020
VL 83
IS 1
AR e13186
DI 10.1111/aji.13186
EA NOV 2019
PG 10
WC Immunology; Reproductive Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Reproductive Biology
GA KA0ZS
UT WOS:000493783000001
PM 31483910
DA 2025-06-11
ER

PT J
AU Nguyen, V
   Berrios, SE
   Leonard, A
   Byrne, ER
   Patel, DP
   Martin, L
   Hsieh, TC
AF Nguyen, Vi
   Berrios, Susana E.
   Leonard, Austin
   Byrne, Eileen R.
   Patel, Darshan P.
   Martin, Leslie
   Hsieh, Tung-Chin
TI Integrated Urology and Primary Care Model Improves Outcomes for Men With
   Testosterone Deficiency
SO UROLOGY PRACTICE
LA English
DT Article
DE metabolic syndrome; primary health care; men's health; hypogonadism
ID HEALTH-CARE; METABOLIC SYNDROME; HYPOGONADISM; DISPARITIES; INSURANCE;
   QUALITY; LATINOS; ACCESS; ADULTS
AB Introduction: Many men presenting with testosterone deficiency do not have access to a primary care provider. We sought to integrate primary care into initial urological evaluation to better identify and manage undertreated comorbidities. Methods: New patients presenting with testosterone deficiency were offered primary care provider evaluation within a men's health center between October 2019 and 2022. Data collected from the electronic health record included age, race, BMI, access to prior primary care provider, new diagnoses, prescriptions, and referrals. Results: Eighty-one men were evaluated over the 3-year study period. Thirty-three men (41%) did not have a preexisting primary care provider. Older men were significantly more likely to have a preexisting primary care provider (OR 1.06 [95% CI: 1.02-1.10], P < .001). Hispanic men were significantly less likely to have an existing primary care provider (OR 0.16 [95% CI: 0.03-0.84], P = .01). Forty-eight men (59%) established continuity of care. Newly diagnosed comorbidities included hypertension (41%), obesity (37%), hyperlipidemia (27%), obstructive sleep apnea (25%), depression (23%), and diabetes (14%). Forty-one patients (51%) were prescribed a new medication. Twenty-one patients (26%) were referred to nutrition, with mean BMI decrease of 1.75 kg/m(2). Twenty-six patients (32%) underwent sleep medicine evaluation for obstructive sleep apnea. Twenty-seven (33%) and 37 patients (46%) received a flu vaccination and immunization updates. Eleven patients (14%) were referred for screening colonoscopy. Conclusions: This is the first report of integrated primary care and urology evaluation for testosterone deficiency. This comprehensive model results in improved outcomes including increased access to subspecialty referrals, objective weight loss, treatment of new diagnoses, updated immunizations, and cancer screening.
C1 [Nguyen, Vi; Berrios, Susana E.; Leonard, Austin; Patel, Darshan P.; Hsieh, Tung-Chin] Univ Calif, Dept Urol, La Jolla, CA 95817 USA.
   [Byrne, Eileen R.] Mayo Clin, Dept Urol, Rochester, MI USA.
   [Martin, Leslie] Univ Calif San Diego, Dept Internal Med, La Jolla, CA USA.
   [Nguyen, Vi] UC San Diego Hlth, Dept Urol, 9300Campus Point Dr, La Jolla 92037, CA USA.
C3 University of California System; University of California San Diego;
   Mayo Clinic; University of California System; University of California
   San Diego
RP Nguyen, V (corresponding author), UC San Diego Hlth, Dept Urol, 9300Campus Point Dr, La Jolla 92037, CA USA.
EM vin016@health.ucsd.edu; sberrios@health.ucsd.edu;
   aleonard@health.ucsd.edu; byrne.eileen@mayo.edu;
   dppatel@health.ucsd.edu; lmartin@health.ucsd.edu;
   t7hsieh@health.ucsd.edu
OI Nguyen, Vi/0000-0003-4363-5009
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NR 20
TC 0
Z9 0
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 2352-0779
EI 2352-0787
J9 UROL PRACT
JI Urol. Pract.
PD NOV
PY 2023
VL 10
IS 6
DI 10.1097/UPJ.0000000000000447
PG 7
WC Urology & Nephrology
WE Emerging Sources Citation Index (ESCI)
SC Urology & Nephrology
GA GD3M3
UT WOS:001150688400009
PM 37647136
DA 2025-06-11
ER

PT J
AU Corona, G
   Wu, FC
   Rastrelli, G
   Lee, DM
   Forti, G
   O'Connor, DB
   O'Neill, TW
   Pendleton, N
   Bartfai, G
   Boonen, S
   Casanueva, FF
   Finn, JD
   Huhtaniemi, IT
   Kula, K
   Punab, M
   Vanderschueren, D
   Rutter, MK
   Maggi, M
AF Corona, Giovanni
   Wu, Frederick C.
   Rastrelli, Giulia
   Lee, David M.
   Forti, Gianni
   O'Connor, Daryl B.
   O'Neill, Terence W.
   Pendleton, Neil
   Bartfai, Gyorgy
   Boonen, Steven
   Casanueva, Felipe F.
   Finn, Joseph D.
   Huhtaniemi, Ilpo T.
   Kula, Krzysztof
   Punab, Margus
   Vanderschueren, Dirk
   Rutter, Martin K.
   Maggi, Mario
CA EMAS Study Grp
TI Low Prolactin Is Associated with Sexual Dysfunction and Psychological or
   Metabolic Disturbances in Middle-Aged and Elderly Men: The European Male
   Aging Study (EMAS)
SO JOURNAL OF SEXUAL MEDICINE
LA English
DT Article
DE Prolactin; Erectile Dysfunction; Metabolic Syndrome
ID CENTRAL SEROTONERGIC RESPONSIVITY; DELAYED EJACULATION;
   ANTERIOR-PITUITARY; CRITICAL ILLNESS; 5-HT2A RECEPTOR; OBESITY; HORMONE;
   HEALTH; HYPERPROLACTINEMIA; TESTOSTERONE
AB Introduction
   We previously reported that in male patients consulting for sexual dysfunction, low prolactin (PRL) levels were associated with metabolic syndrome (MetS), arteriogenic erectile dysfunction, and incident major cardiovascular events.
   Aim
   The aim of this study is to assess the clinical associations of PRL levels in the European Male Ageing Study (EMAS).
   Methods
   EMAS is a prospective, observational cohort of community-dwelling men aged 40-79 years old (mean age 60 +/- 11 years old). PRL was available for 2,948 men.
   Main Outcome Measures
   Different parameters were evaluated including the Short Form-36 questionnaire, Becks Depression Inventory, the Adverse Life Events Scale, the Physical Activity Scale for the Elderly, and the EMAS sexual function questionnaire (EMAS-SFQ).
   Results
   After the adjustment for confounders, PRL levels were inversely related with worsening of sexual function as compared with the previous year, as derived from change in sexual functioning domain of the EMAS-SFQ (adj. r=-0.043; P=0.029). The strongest correlation (Wald=6.840; P=0.009) was observed between lower PRL levels and reduced enjoyment of orgasmic experiences. Furthermore, an inverse relationship between PRL levels and stressful life events or depressive symptoms was observed. Low PRL was also negatively associated with an unhealthy metabolic phenotype as well as with the MetS (Wald=5.229; P=0.022). In line with these data, low PRL was associated with a lower level of physical activity and feeling unhealthier.
   Conclusions
   Low PRL is related to several metabolic, psychological, and sexual unhealthy characteristics in European men. Checking PRL might be useful to stratify men for cardiovascular risk and to encourage appropriate lifestyle changes.
C1 [Corona, Giovanni; Rastrelli, Giulia; Maggi, Mario] Univ Florence, Sexual Med & Androl Unit, Dept Expt Clin & Biomed Sci, I-50139 Florence, Italy.
   [Corona, Giovanni] Azienda Usl Bologna Maggiore Bellaria Hosp, Dept Med, Endocrinol Unit, Bologna, Italy.
   [Wu, Frederick C.] Univ Manchester, Manchester Royal Infirm, Dept Endocrinol, Manchester M13 9WL, Lancs, England.
   [Lee, David M.; O'Neill, Terence W.; Finn, Joseph D.] Univ Manchester, Epidemiol Unit, Manchester, Lancs, England.
   [Forti, Gianni] Univ Florence, Endocrinol Unit, Dept Expt Clin & Biomed Sci, I-50139 Florence, Italy.
   [O'Connor, Daryl B.] Univ Leeds, Inst Psychol Sci, Leeds, W Yorkshire, England.
   [Pendleton, Neil] Univ Manchester, Hope Hosp, Salford M6 8HD, Lancs, England.
   [Bartfai, Gyorgy] Albert Szent Gyorgy Med Univ, Szeged, Hungary.
   [Boonen, Steven] Katholieke Univ Leuven, Div Gerontol & Geriatr, Leuven, Belgium.
   [Boonen, Steven] Katholieke Univ Leuven, Ctr Musculoskeletal Res, Dept Expt Med, Leuven, Belgium.
   [Casanueva, Felipe F.] Univ Santiago de Compostela, CHUS, Dept Med, CIBER Fisiopatol Obesidad Nutr CB06 03,Inst Salud, Santiago De Compostela, Spain.
   [Huhtaniemi, Ilpo T.] Univ London Imperial Coll Sci Technol & Med, Dept Reprod Biol, London, England.
   [Kula, Krzysztof] Med Univ Lodz, Dept Androl & Reprod Endocrinol, Lodz, Poland.
   [Punab, Margus] Tartu Univ Clin, Androl Unit, United Labs, Tartu, Estonia.
   [Vanderschueren, Dirk] Katholieke Univ Leuven, Dept Androl & Endocrinol, Louvain, Belgium.
   [Rutter, Martin K.] Univ Manchester, Sch Biomed, Cardiovasc Res Grp, Manchester, Lancs, England.
C3 University of Florence; AUSL di Bologna; University of Manchester;
   University of Manchester; University of Florence; University of Leeds;
   University of Manchester; Szeged University; KU Leuven; KU Leuven;
   Universidade de Santiago de Compostela; CIBER - Centro de Investigacion
   Biomedica en Red; CIBEROBN; Complexo Hospitalario Universitario de
   Santiago de Compostela; Imperial College London; Medical University
   Lodz; University of Tartu; KU Leuven; University of Manchester
RP Corona, G (corresponding author), Univ Florence, Sexual Med & Androl Unit 1, Dept Expt Clin & Biomed Sci, Viale Pieraccini 6, I-50139 Florence, Italy.
EM m.maggi@dfc.unifi.it
RI Woo, Jean/K-2625-2014; , Margus Punab/KXS-1159-2024; Maggi,
   Mario/AAB-8284-2019; Rutter, Michael/C-8570-2013; Kujala,
   Urho/AAP-2547-2020; Pendleton, Neil/F-2333-2015; Pye,
   Stephen/D-9236-2011; Lee, David/D-1005-2009
OI Rutter, Martin/0000-0001-6380-539X; Pendleton, Neil/0000-0003-0794-2386;
   Rastrelli, Giulia/0000-0002-6164-4278; vanderschueren,
   dirk/0000-0003-1395-0104; MAGGI, Mario/0000-0003-3267-4221; Pye,
   Stephen/0000-0002-7263-2897; O'Connor, Daryl/0000-0003-4117-4093; Lee,
   David/0000-0003-3472-0789; Punab, Margus/0000-0001-9601-6311; O'Neill,
   Terence/0000-0002-8896-4677
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NR 64
TC 73
Z9 76
U1 0
U2 16
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1743-6095
EI 1743-6109
J9 J SEX MED
JI J. Sex. Med.
PD JAN
PY 2014
VL 11
IS 1
BP 240
EP 253
DI 10.1111/jsm.12327
PG 14
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA AE9ML
UT WOS:000334331800028
PM 24345293
DA 2025-06-11
ER

PT J
AU Blair, YA
   Doherty, L
   Temprosa, M
   Pop-Busui, R
   Gadde, KM
   Singh, P
   Owora, AH
   Wessells, H
   Sarma, AV
AF Blair, Yooni A.
   Doherty, Lindsay
   Temprosa, Marinella
   Pop-Busui, Rodica
   Gadde, Kishore M.
   Singh, Prachi
   Owora, Arthur H.
   Wessells, Hunter
   V. Sarma, Aruna
TI Prevalence and predictors of erectile dysfunction among men in the
   diabetes prevention program outcomes study
SO JOURNAL OF DIABETES AND ITS COMPLICATIONS
LA English
DT Article
DE Prediabetes; Diabetes; Erectile dysfunction
ID LIFE-STYLE INTERVENTION; METABOLIC SYNDROME; RISK-FACTORS;
   PHYSICAL-ACTIVITY; FOLLOW-UP; ASSOCIATION; METFORMIN; HEALTH;
   METAANALYSIS; POPULATION
AB Objective: To determine burden and identify correlates of erectile dysfunction (ED) among men with prediabetes (PreD) and type 2 diabetes (T2D) enrolled in the Diabetes Prevention Program (DPP) Outcomes Study (DPPOS). Research design and methods: The 2017 DPPOS visit included administration of the International Index of Erectile Function. Of 648 male participants, 88 % (n = 568) completed the survey. Associations between sociodemographic, behavioral, clinical, and glycemic measures at time of ED assessment, and ED were examined using multivariable logistic regression models in men with PreD and T2D separately. Results: Overall, 218 (38 %) men met ED criteria. Prevalence was similar in men with PreD (41 %) and T2D (37 %) (p = 0.4). In all men, age (p < 0.001) increased odds of ED. Among men with PreD, those assigned to intensive lifestyle intervention (ILS), but not metformin, had decreased odds of ED compared with the placebo group (OR = 0.35, 95 % CI = 0.13, 0.94). Non-Hispanic White race was associated with increased odds of ED compared with other races (OR = 4.3; 95 % CI = 1.92, 9.65). Among men with T2D, ED risk did not differ by DPP treatment assignment; however, individuals with metabolic syndrome defined by National Cholesterol Education Program criteria, had increased odds of ED (OR = 1.85, 95 % CI = 1.14, 3.01), as did individuals with depression (OR = 2.05; 95 % CI = 1.10, 3.79). Conclusions: ED is prevalent in men with PreD and T2D. Our finding of reduced odds of ED in men randomized to ILS and with PreD suggests a potential opportunity for risk mitigation in the prediabetes interval. In men who have progressed to T2D, metabolic factors appear to be associated with ED.
C1 [Blair, Yooni A.; V. Sarma, Aruna] Univ Michigan, Dept Urol, Ann Arbor, MI USA.
   [Doherty, Lindsay; Temprosa, Marinella] George Washington Univ, Milken Inst, Biostat Ctr, Sch Publ Hlth, Rockville, MD USA.
   [Pop-Busui, Rodica] Univ Michigan, Div Metab Endocrinol & Diabet, Ann Arbor, MI USA.
   [Gadde, Kishore M.] Univ Calif Irvine, Dept Surg, Orange, CA USA.
   [Singh, Prachi] Louisiana State Univ Syst, Pennington Biomed Res Ctr, Baton Rouge, LA USA.
   [Owora, Arthur H.] Indiana Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Bloomington, IN USA.
   [Wessells, Hunter] Univ Washington, Diabet Res Ctr, Sch Med, Dept Urol, Seattle, WA USA.
   [Blair, Yooni A.] 1500 Med Ctr Dr SPC 533, Ann Arbor, MI 48109 USA.
C3 University of Michigan System; University of Michigan; George Washington
   University; University of Michigan System; University of Michigan;
   University of California System; University of California Irvine;
   Louisiana State University System; Louisiana State University;
   Pennington Biomedical Research Center; Indiana University System;
   Indiana University Bloomington; University of Washington; University of
   Washington Seattle
RP Blair, YA (corresponding author), 1500 Med Ctr Dr SPC 533, Ann Arbor, MI 48109 USA.
EM yooniy@med.umich.edu
RI Owora, Arthur/X-3389-2019; Gadde, Kishore/N-1963-2017; Singh,
   Prachi/F-8491-2011
OI Singh, Prachi/0000-0002-7392-9035
FU Media Group, Inc.; Henry M. Jackson Foundation
FX This study was supported by the NIDDK Diabetic Complications Consortium
   (RRID:SCR_001415, www.diacomp.org) , grants DK076169 and
   DK115255.Further, the DPP Research Group gratefully acknowledges the
   commitment and dedication of the participants of the DPP and DPPOS.
   Research reported in this publication was supported by the National
   Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) of the
   National Institutes of Health (NIH) under award numbers U01 DK048489,
   U01 DK048339, U01 DK048377, U01 DK048349, U01 DK048381, U01 DK048468,
   U01 DK048434, U01 DK048485, U01 DK048375, U01 DK048514, U01 DK048437,
   U01 DK048413, U01 DK048411, U01 DK048406, U01 DK048380, U01 DK048397,
   U01 DK048412, U01 DK048404, U01 DK048387, U01 DK048407, U01 DK048443,
   U01 DK048400, U01 DK076169 and U01 DK115255 by providing funding during
   DPP and DPPOS to the clinical centers and the Coordinating Center for
   the design and conduct of the study, and collection, management,
   analysis, and interpretation of the data. Funding was also provided by
   the National Institute of Child Health and Human Development, the
   National Institute on Aging, the National Eye Institute, the National
   Heart, Lung, and Blood Institute, the National Cancer Institute, the
   Office of Research on Women's Health, the National Institute on Minority
   Health and Health Disparities, the Centers for Disease Control and
   Prevention, and the American Diabetes Association. The content is solely
   the responsibility of the authors and does not necessarily represent the
   official views of the National Institutes of Health. The Southwestern
   American Indian Centers were supported directly by the NIDDK, including
   its Intramural Research Program, and the Indian Health Service. The
   General Clinical Research Center Program, National Center for Research
   Resources, and the Department of Veterans Affairs supported data
   collection at many of the clinical centers. Merck KGaA provided
   medication for DPPOS. DPP/DPPOS have also received donated materials,
   equipment, or medicines for concomitant conditions from Bristol-Myers
   Squibb, Parke-Davis, and LifeScan Inc., Health O Meter, Hoechst Marion
   Roussel, Inc., Merck-Medco Managed Care, Inc., Merck and Co., Nike
   Sports Marketing, Slim Fast Foods Co., and Quaker Oats Co. McKesson
   BioServices Corp., Matthews Media Group, Inc., and the Henry M. Jackson
   Foundation provided support services under subcontract with the
   Coordinating Center. The sponsor of this study was represented on the
   Steering Committee and played a part in study design, how the study was
   done, and publication. All authors in the writing group had access to
   all data. The opinions expressed are those of the study group and do not
   necessarily reflect the views of the funding agencies. A complete list
   of Centers, investigators, and staff can be found in the Appendix.r
   Media Group, Inc., and the Henry M. Jackson Foundation provided support
   services under subcontract with the Coordinating Center. The sponsor of
   this study was represented on the Steering Committee and played a part
   in study design, how the study was done, and publication. All authors in
   the writing group had access to all data. The opinions expressed are
   those of the study group and do not necessarily reflect the views of the
   funding agencies. A complete list of Centers, investigators, and staff
   can be found in the Appendix.
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NR 42
TC 0
Z9 0
U1 0
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1056-8727
EI 1873-460X
J9 J DIABETES COMPLICAT
JI J. Diabetes Complications
PD FEB
PY 2024
VL 38
IS 2
AR 108669
DI 10.1016/j.jdiacomp.2023.108669
EA JAN 2024
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA ID3N1
UT WOS:001164349300001
PM 38219334
DA 2025-06-11
ER

PT J
AU Kiani, FZ
   Ahmadi, A
AF Kiani, Fatemeh Zeynab
   Ahmadi, Ali
TI Prevalence of different comorbidities in chronic obstructive pulmonary
   disease among Shahrekord PERSIAN cohort study in southwest Iran
SO SCIENTIFIC REPORTS
LA English
DT Article
ID COPD; BURDEN
AB Comorbidities are common in chronic obstructive pulmonary disease (COPD) patients. This study was conducted to determine the prevalence of common comorbidities in patients with COPD compared with people without COPD. This cross-sectional, population-based study was performed on 6961 adults aged 35-70 years enrolled in the Shahrekord PERSIAN cohort study. Data (demographic and clinical characteristics, comorbidities, anthropometric and blood pressure measurements, laboratory, and spirometry tests) collection was performed according to the cohort protocol from 2015 to 2019. In the present study, 215 (3.1%) patients were diagnosed with COPD and 1753 (25.18%) ones with restrictive lung patterns. The mean age of COPD patients was 52.5 +/- 9.76 years. 55.8% of patients were male, 17.7% were current smokers and 12.1% had a history of smoking or were former smokers. 5.6% of patients had no comorbidity and 94.5% had at least one comorbidity. The most common comorbidities in COPD patients were dyslipidemia (70.2%), hypertension (30.2%), metabolic syndrome (22.8%), and diabetes (16.7%). The most common comorbidities in individuals with a restrictive spirometry pattern were dyslipidemia (68.9%), metabolic syndrome (27.2%), hypertension (26.1%), depression (17.6%), and fatty liver (15.5%). The logistic regression analysis with 95% confidence interval (95%CI) of odds ratio (OR) showed that comorbidities of chronic lung diseases (OR=2.12, 95% CI 1.30-3.44), diabetes (OR=1.54, 95%CI 1.03-2.29), cardiovascular disease (OR=1.52, 95%CI 1.17-2.43), and hypertension (OR=1.4, 95%CI 1.02-1.99) were more likely to occur in COPD patients than in healthy individuals. Knowing these prevalence rates and related information provides new insights on comorbidities to reduce disease burden and develop preventive interventions and to regulate health care resources to meet the needs of patients in primary health care.
C1 [Kiani, Fatemeh Zeynab; Ahmadi, Ali] Shahrekord Univ Med Sci, Modeling Hlth Res Ctr, Shahrekord, Iran.
   [Ahmadi, Ali] Shahrekord Univ Med Sci, Dept Epidemiol & Biostat, Sch Hlth & Modeling Hlth Res Ctr, Shahrekord, Iran.
C3 Shahrekord University Medical Sciences; Shahrekord University Medical
   Sciences
RP Ahmadi, A (corresponding author), Shahrekord Univ Med Sci, Modeling Hlth Res Ctr, Shahrekord, Iran.; Ahmadi, A (corresponding author), Shahrekord Univ Med Sci, Dept Epidemiol & Biostat, Sch Hlth & Modeling Hlth Res Ctr, Shahrekord, Iran.
EM aliahmadi2007@gmail.com
RI ahmadi, ali/JMC-5690-2023
OI Kiani, Fatemehzeynab/0000-0001-8790-6910; Ahmadi,
   Ali/0000-0002-1588-2136
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NR 48
TC 19
Z9 23
U1 3
U2 6
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD JAN 15
PY 2021
VL 11
IS 1
AR 1548
DI 10.1038/s41598-020-79707-y
PG 8
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA PV1VP
UT WOS:000609782400069
PM 33452286
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Zhai, RN
   Dong, XS
   Feng, L
   Li, SL
   Hu, ZY
AF Zhai, Ruina
   Dong, Xusheng
   Feng, Lei
   Li, Shengli
   Hu, Zhiyong
TI The Effect of Heat Stress on Autophagy and Apoptosis of Rumen, Abomasum,
   Duodenum, Liver and Kidney Cells in Calves
SO ANIMALS
LA English
DT Article
DE autophagy; apoptosis; heat stress; calf
ID INTESTINAL PERMEABILITY; METABOLIC SYNDROME; SKELETAL-MUSCLE;
   MAMMARY-GLAND; DRY PERIOD; FRUCTOKINASE; INSULIN; COWS
AB Simple Summary Heat stress causes significant negative responses in the dairy industry. The objective of this study was to assess the effect of heat stress on the autophagy and apoptosis of the rumen, abomasum, duodenum, liver and kidney in calves. The results showed that heat stress could increase the autophagy and apoptosis of the kidney, duodenum and abomasum. However, heat stress had no effect on the autophagy and apoptosis of the liver. In cows, most studies of autophagy and apoptosis have only focused on mammary remodeling. Our results provide new knowledge regarding autophagy and autophagy in calf heat stress management.
   Abstract The objective of this study was to assess the effect of heat stress on the autophagy and apoptosis of the rumen, abomasum, duodenum, liver and kidney in calves. Two groups of Holstein male calves were selected with similar birth weights and health conditions. Heat stress (HT): Six calves (birth weight 42.2 +/- 2.3) were raised from July 15 to August 19. Cooling (CL): Six calves (birth weight 41.5 +/- 3.1 kg) were raised from April 10 to May 15. All the calves were euthanized following captive bolt gun stunning at 35 d of age. The expression of protein 1 light chain 3-? (LC3-?) and caspase3 in the rumen, abomasum, duodenum, liver and kidney were determined by western blotting. In addition, other possible relevant serum biochemical parameters were evaluated. Significant differences were observed in alkaline phosphatase (ALP), albumin (ALB) and glucose (Glu). The results showed that heat stress could increase the autophagy and apoptosis of the kidney, duodenum and abomasum. However, heat stress had no effect on the autophagy and apoptosis of the liver. Additionally, the expression of caspase-3 in the rumen in HT was significantly lower than that in CL. In conclusion, the effects of heat stress on autophagy and apoptosis are organ-specific. The results provide knowledge regarding autophagy and autophagy in calf heat stress management.
C1 [Zhai, Ruina] Xinjiang Agr Univ, Coll Anim Sci, Urumqi 830052, Peoples R China.
   [Dong, Xusheng; Feng, Lei; Hu, Zhiyong] Shandong Agr Univ, Coll Anim Sci & Technol, Ruminant Nutr & Physiol Lab, Tai An 271018, Shandong, Peoples R China.
   [Li, Shengli] China Agr Univ, Coll Anim Sci & Technol, State Key Lab Anim Nutr, Beijing 100193, Peoples R China.
C3 Xinjiang Agricultural University; Shandong Agricultural University;
   China Agricultural University
RP Hu, ZY (corresponding author), Shandong Agr Univ, Coll Anim Sci & Technol, Ruminant Nutr & Physiol Lab, Tai An 271018, Shandong, Peoples R China.; Li, SL (corresponding author), China Agr Univ, Coll Anim Sci & Technol, State Key Lab Anim Nutr, Beijing 100193, Peoples R China.
EM 18562301385@163.com; 17863801700@163.com; Flei0921@163.com;
   lisheng0677@163.com; huzhiyong@sdau.edu.cn
FU National Natural Science Foundation of China [31772624]; National Key
   Research and Development Program of China [2018YFD0501600]
FX This research was funded by the National Natural Science Foundation of
   China, grant number 31772624, National Key Research and Development
   Program of China, grant number 2018YFD0501600.
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NR 42
TC 21
Z9 22
U1 4
U2 25
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 2076-2615
J9 ANIMALS-BASEL
JI Animals
PD OCT
PY 2019
VL 9
IS 10
AR 854
DI 10.3390/ani9100854
PG 8
WC Agriculture, Dairy & Animal Science; Veterinary Sciences; Zoology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture; Veterinary Sciences; Zoology
GA JN2UY
UT WOS:000496757200151
PM 31652592
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Yaprak, B
   Arslan, N
   Alatas, H
AF Yaprak, Bulent
   Arslan, Nurgul
   Alatas, Hacer
TI Factors Affect the Quality of Sleep in Elderly People with Metabolic
   Syndrome
SO EURASIAN JOURNAL OF EMERGENCY MEDICINE
LA English
DT Article
DE Elderly; metabolc syndrome; sleep quality index
ID OLDER-ADULTS; DURATION; ASSOCIATION; MOBILITY; BALANCE; SCALE; RISK;
   LIFE
AB Aim: As more studies are conducted on the effects of metabolic syndrome (MetS) on the elderly, it becomes clear that these individuals suffer from worse sleep. In this study, we examined the factors affecting sleep quality in the elderly diagnosed with MetS.Materials and Methods: The study was conducted in the Internal Medicine Clinic of Malatya Training and Research Hospital. Elderly people over the age of 65 years, willing to cooperate, able to communicate, and scored 23 and above on the Standard Mini Mental Test were recruited. The individuals included in the study were individuals who met the criteria for MetS. A comprehensive geriatric evaluation form was applied to elderly individuals.Results: The study's 378 participants had mean age of 72.05 & PLUSMN;6.56 years. People over the age of 60 who had high values for both their body mass index (BMI) and their waist-hip ratio also had high Pittsburgh Sleep Quality Index scores (p<0.05). The factors affecting sleep quality were examined by regression analysis. As a result of, having a BMI of 30 or higher [odds ratio (OR): 2.831, confidence interval (CI): 0.081-2.525], being 75 or older (OR: 2.021, CI: 0.081-2.525), being totally or partially dependent on others for the performance of daily activities (OR: 5.024, CI: 2.408-5.165), and using multiple drugs (OR: 2.831, 0.734-2.901), an increased likelihood of falling (OR: 4.871, CI: 1.056-6.146), an increased likelihood of depression (OR: 3.850, CI: 1.355-3.973) increases sleep quality index scores.Conclusion: The elderly individuals who already have MetS are more likely to have poor sleep quality due to the accumulation of many detrimental factors that arise as a direct result of MetS.
C1 [Yaprak, Bulent] Malatya Training & Res Hosp, Clin Internal Med, Malatya, Turkiye.
   [Arslan, Nurgul] Dicle Univ, Ataturk Fac Hlth Sci, Dept Nutr & Dietet, Diyarbakir, Turkiye.
   [Alatas, Hacer] Malatya Training & Res Hosp, Clin Nutr & Dietet, Malatya, Turkiye.
C3 Malatya State Hospital; Dicle University; Malatya State Hospital
RP Arslan, N (corresponding author), Dicle Univ, Ataturk Fac Hlth Sci, Dept Nutr & Dietet, Diyarbakir, Turkiye.
EM nuracar_1986@hotmail.com
RI ARSLAN, Nurgül/ABM-5700-2022; alataş, hacer/HKO-8944-2023
OI Arslan, Nurgul/0000-0002-7618-0859; YAPRAK, BULENT/0000-0001-5592-9755;
   ALATAS, HACER/0000-0002-6441-0362
CR Agargun M.Y., 1996, T RK PSIKIYATRI DERG, V7, P107
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NR 39
TC 1
Z9 1
U1 0
U2 4
PU GALENOS PUBL HOUSE
PI ISTANBUL
PA Kacamak Sokak 21/1, ISTANBUL, Findikzade, TURKEY
SN 2149-5807
EI 2149-6048
J9 EURASIAN J EMERG MED
JI Eurasian J. Emerg. Med.
PD JUN
PY 2023
VL 22
IS 2
BP 121
EP 127
DI 10.4274/eajem.galenos.2023.41961
PG 7
WC Emergency Medicine
WE Emerging Sources Citation Index (ESCI)
SC Emergency Medicine
GA L2ST8
UT WOS:001021816100010
OA gold
DA 2025-06-11
ER

PT J
AU Fuller-Rowell, TE
   Homandberg, LK
   Curtis, DS
   Tsenkova, VK
   Williams, DR
   Ryff, CD
AF Fuller-Rowell, Thomas E.
   Homandberg, Lydia K.
   Curtis, David S.
   Tsenkova, Vera K.
   Williams, David R.
   Ryff, Carol D.
TI Disparities in insulin resistance between black and white adults in the
   United States: The role of lifespan stress exposure
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE Adult psychosocial stress; Adverse childhood experiences; Insulin
   resistance; Cortisol; Inflammation; Health inequalities
ID ADVERSE CHILDHOOD EXPERIENCES; HOMEOSTASIS MODEL ASSESSMENT; PERCEIVED
   DISCRIMINATION; METABOLIC SYNDROME; EDUCATIONAL-ATTAINMENT;
   SOCIOECONOMIC-STATUS; AFRICAN-AMERICAN; ALLOSTATIC LOAD; DIABETES RISK;
   HEALTH
AB Background: Disparities in insulin resistance between Black and White adults in the United States are well documented, yet relatively little is known about the psychosocial or biological antecedents of these inequities. The current study examined childhood adversity and contemporaneous psychosocial stressors in adulthood as possible mediators of the racial disparity in insulin resistance. Inflammatory and hypothalamic-pituitary adrenal (HPA) axis mechanisms implicated in associations between lifespan stress exposure and insulin resistance were also considered.
   Methods: Data were derived from the biomarker component of the Midlife in the United States Study (N = 1170, 20% Black, 56% female, Mean age = 54.7 years, SD = 11.6). A homeostatic model assessment of insulin resistance (HOMA-IR) was calculated from fasting glucose and insulin concentrations. Twelve risk factors relating to household dysfunction, socioeconomic disadvantage, and maltreatment were sum scored to index childhood adversity. Measures of adult stress included socioeconomic adversity, major stressful events, everyday discrimination, and lifetime discrimination.
   Results: Levels of insulin resistance were higher among Black than White adults. Childhood adversity was positively associated with HOMA-IR, and attenuated 18% of the race difference. Measures of adult stress mediated 33% of the association between childhood adversity and HOMA-IR, and accounted for an additional 47% of the race difference. Higher inflammation and lower nocturnal cortisol both played an important role in mediating the association between stress exposure and HOMA-IR.
   Conclusions: Findings are consistent with prior research showing that childhood adversity and adult stress are salient predictors of glucose metabolism, and extend this work by showing that lifespan stress exposures attenuate a significant portion of the Black-White disparity in HOMA-IR. Results also suggest stress effects on insulin resistance through inflammatory and HPA-axis pathways.
C1 [Fuller-Rowell, Thomas E.; Homandberg, Lydia K.] Auburn Univ, Dept Human Dev & Family Studies, 203 Spidle Hall, Auburn, AL 36849 USA.
   [Curtis, David S.] Univ Utah, Dept Family & Consumer Studies, Salt Lake City, UT USA.
   [Tsenkova, Vera K.] Univ Wisconsin, Sch Med & Publ Hlth, Madison, WI USA.
   [Williams, David R.] Harvard Univ, Dept Social & Behav Sci, Cambridge, MA 02138 USA.
   [Ryff, Carol D.] Univ Wisconsin, Dept Psychol, 1202 W Johnson St, Madison, WI 53706 USA.
C3 Auburn University System; Auburn University; Utah System of Higher
   Education; University of Utah; University of Wisconsin System;
   University of Wisconsin Madison; Harvard University; University of
   Wisconsin System; University of Wisconsin Madison
RP Fuller-Rowell, TE (corresponding author), Auburn Univ, Dept Human Dev & Family Studies, 203 Spidle Hall, Auburn, AL 36849 USA.
EM tef0005@auburn.edu
RI Williams, David/JEO-2461-2023; Curtis, David/K-7274-2019
OI Curtis, David/0000-0001-5084-7734; Homandberg, Lydia/0000-0003-3709-8710
FU John D. and Catherine T. MacArthur Foundation Research Network on
   Successful Midlife Development; National Institute on Aging
   [P01-AG020166]; NIH National Center for Advancing Translational Sciences
   (NCATS) Clinical and Translational Science Award (CTSA) program
   [UL1TR001409, UL1TR001881, 1UL1RR025011]; USDA National Institute of
   Food and Agriculture [1003947]
FX MIDUS 1 (Midlife in the U.S.) was supported by the John D. and Catherine
   T. MacArthur Foundation Research Network on Successful Midlife
   Development. MIDUS 2 was supported by the National Institute on Aging
   (P01-AG020166). Further support for biomarker collection was provided by
   the NIH National Center for Advancing Translational Sciences (NCATS)
   Clinical and Translational Science Award (CTSA) program as follows:
   UL1TR001409 (Georgetown), UL1TR001881 (UCLA), 1UL1RR025011 (UW). Funding
   was also provided by the USDA National Institute of Food and Agriculture
   for analysis and write-up of this manuscript (Hatch project 1003947). An
   earlier version of this paper was presented at the Annual Meeting of the
   American Psychosomatic Society, March 2018.
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NR 52
TC 24
Z9 30
U1 0
U2 14
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD SEP
PY 2019
VL 107
BP 1
EP 8
DI 10.1016/j.psyneuen.2019.04.020
PG 8
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA IU2LO
UT WOS:000483412100001
PM 31055182
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Abdoli, N
   Salari, N
   Farnia, V
   Khodamoradi, M
   Jahangiri, S
   Mohammadi, M
   Brühl, AB
   Sadeghi-Bahmani, D
   Brand, S
AF Abdoli, Nasrin
   Salari, Nader
   Farnia, Vahid
   Khodamoradi, Mehdi
   Jahangiri, Somayeh
   Mohammadi, Masoud
   Bruhl, Annette Beatrix
   Sadeghi-Bahmani, Dena
   Brand, Serge
TI Risk-Taking Behavior among Suicide Attempters
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Article
DE risk-taking behavior; suicidal behavior; suicide attempts
ID METABOLIC SYNDROME; BIPOLAR DISORDERS; IMPULSIVITY; IDEATION;
   EPIDEMIOLOGY; SEEKING; CRISIS; ADULT; RATES
AB Background: Suicidal behavior is a major mental health concern both for the individual and for the public health. Among others, suicidal behavior is associated with impulsivity, risk taking, pain tolerance, and a state of overarousal. In the present study, we investigated if suicide attempters (SAs) reported higher scores for risk-taking when compared with healthy controls (HC) of the general population. Methods: A total of 616 individuals (mean age: 27.07 years; 51.5% females) took part in the study; of those, 240 (39%) were individuals with a suicide attempt (SA) within a time lapse of one to three months, and 376 (61%) were healthy controls (HC). Participants completed a series of self-rating questionnaires covering sociodemographic information, risk-taking (Risk-Taking Questionnaire 18; RT-18), and suicidal behavior (Suicide Behaviors Questionnaire-Revised; SBQ-R). Results: Compared with HCs, individuals with SA reported higher risk-taking and suicidal behavior scores. The risk-taking questionnaire yielded a four-factor solution: Thrill and sensation seeking; Cautious procedure; Cautious decision making; Impulsive behavior. Compared with HCs, SAs showed the highest scores for thrill and sensation seeking and impulsive behavior. Conclusions: Compared with healthy controls, individuals reporting a recent suicide attempt also reported a higher propensity to thrill and sensation seeking and impulsive behavior as a proxy of risk-taking behavior. The present results corroborate the notion that, among others, suicide attempts appeared to be less related to premeditation, but rather to impulsive and thus spontaneous behavior.
C1 [Abdoli, Nasrin; Salari, Nader; Farnia, Vahid; Khodamoradi, Mehdi; Jahangiri, Somayeh; Brand, Serge] Kermanshah Univ Med Sci, Subst Abuse Prevent Res Ctr, Hlth Inst, Kermanshah 6719851115, Iran.
   [Salari, Nader] Kermanshah Univ Med Sci, Sch Hlth, Dept Biostat, Kermanshah 6719851115, Iran.
   [Salari, Nader; Sadeghi-Bahmani, Dena; Brand, Serge] Kermanshah Univ Med Sci, Sleep Disorders Res Ctr, Kermanshah 6719851115, Iran.
   [Mohammadi, Masoud] Gerash Univ Med Sci, Cellular & Mol Res Ctr, Gerash 7441758666, Iran.
   [Bruhl, Annette Beatrix; Sadeghi-Bahmani, Dena; Brand, Serge] Univ Basel, Ctr Affect Stress & Sleep Disorders, Psychiat Clin, CH-4002 Basel, Switzerland.
   [Sadeghi-Bahmani, Dena] Stanford Univ, Dept Psychol, Stanford, CA 94305 USA.
   [Brand, Serge] Univ Basel, Div Sport Sci & Psychosocial Hlth, Dept Sport Exercise & Hlth, CH-4052 Basel, Switzerland.
   [Brand, Serge] Univ Tehran Med Sci, Sch Med, Tehran 1417466191, Iran.
C3 Kermanshah University of Medical Sciences; Kermanshah University of
   Medical Sciences; Kermanshah University of Medical Sciences; University
   of Basel; Stanford University; Swiss School of Public Health (SSPH+);
   University of Basel; Tehran University of Medical Sciences
RP Brand, S (corresponding author), Kermanshah Univ Med Sci, Subst Abuse Prevent Res Ctr, Hlth Inst, Kermanshah 6719851115, Iran.; Brand, S (corresponding author), Kermanshah Univ Med Sci, Sleep Disorders Res Ctr, Kermanshah 6719851115, Iran.; Brand, S (corresponding author), Univ Basel, Ctr Affect Stress & Sleep Disorders, Psychiat Clin, CH-4002 Basel, Switzerland.; Brand, S (corresponding author), Univ Basel, Div Sport Sci & Psychosocial Hlth, Dept Sport Exercise & Hlth, CH-4052 Basel, Switzerland.; Brand, S (corresponding author), Univ Tehran Med Sci, Sch Med, Tehran 1417466191, Iran.
EM abdolinasrin511@yahoo.com; n_s_514@yahoo.com; vahidfarnia@yahoo.com;
   mehdi0khodamoradi@gmail.com; jahangirisomayeh84@gmail.com;
   masoud.mohammadi1989@yahoo.com; annette.bruehl@upk.ch;
   bahmanid@stanford.edu; serge.brand@upk.ch
RI Brand, Serge/H-7159-2019; Bahmani, Dena/H-8271-2019; Abdoli,
   Nasrin/N-8384-2017; Mohammadi, Masoud/N-5971-2017; Bruhl,
   Annette/A-5272-2013
OI Mohammadi, Masoud/0000-0002-5722-8300; Brand, Serge/0000-0003-2175-2765;
   Salari, Nader/0000-0003-3550-405X; Bruhl, Annette/0000-0003-4704-4986;
   Sadeghi Bahmani, Dena/0000-0002-1301-5522
FU Iran National Science Foundation (INSF), Iran [97011213]
FX This article is the result of the findings of the research project
   97011213 that was approved and financially supported by the Iran
   National Science Foundation (INSF), Iran.
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NR 63
TC 5
Z9 5
U1 3
U2 21
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD JUL
PY 2022
VL 11
IS 14
AR 4177
DI 10.3390/jcm11144177
PG 13
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 3G8MJ
UT WOS:000831601700001
PM 35887941
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Castillejos, MC
   Martín-Pérez, C
   García-Ruiz, A
   Mayoral-Cleries, F
   Moreno-Küstner, B
AF Castillejos, M. Carmen
   Martin-Perez, Carlos
   Garcia-Ruiz, Antonio
   Mayoral-Cleries, Fermin
   Moreno-Kustner, Berta
TI Recording of cardiovascular risk factors by general practitioners in
   patients with schizophrenia
SO ANNALS OF GENERAL PSYCHIATRY
LA English
DT Article
DE Cardiovascular disorders; Medical comorbidity; Mental health; Primary
   care; Severe mental illness
ID SEVERE MENTAL-ILLNESS; METABOLIC SYNDROME; SOCIODEMOGRAPHIC FACTORS;
   PREVALENCE; DISEASE; PEOPLE; DISORDERS; CARE
AB Background Patients with schizophrenia and related disorders (SRD) are more predisposed to having cardiovascular risk factors (CVRFs) compared to the general population due to a combination of lifestyle factors and exposure to antipsychotic medications. We aimed to analyse the documentation practices of CVRFs by general practitioners (GPs) and its associations with patient variables in a sample of persons with SRD. Methods An observational, cross-sectional study was conducted in 13 primary care centres (PCCs) in Malaga (Spain). The population comprised all patients with SRD who were in contact with a GP residing in the study area. The number of CVRFs (type 2 diabetes mellitus, hypertension, hypercholesterolaemia, obesity and smoking) recorded by GPs were analysed by considering patients' demographic and clinical variables and use of primary care services. We performed descriptive, bivariate and multivariate regression analyses. Results A total of 494 patients were included; CVRFs were not recorded in 59.7% of the patients. One CVRF was recorded in 42.1% of patients and two or more CVRFs were recorded in 16.1% of patients. Older age, living in an urban area and a higher number of visits to the GP were associated with a higher number of CVRFs recorded. Conclusion The main finding in this study is that both patients' demographic variables as well as use of primary care services were found to be related to the documentation of CVRFs in patients with SRD by GPs.
C1 [Castillejos, M. Carmen] Univ Malaga, Fac Psychol, Dept Personal Assessment & Psychol Treatment, Andalusian Grp Psychosocial Res GAP, Campus Teatinos, Malaga 29071, Spain.
   [Martin-Perez, Carlos] Andalusian Hlth Serv, Clin Management Unit Marquesado, Carretera Pozos, Granada 18518, Spain.
   [Garcia-Ruiz, Antonio] Univ Malaga, Dept Hlth Econ & Rat Drug Use Med, Fac Med, Campus Teatinos, Malaga 29071, Spain.
   [Mayoral-Cleries, Fermin] Biomed Res Inst Malaga IBIMA, Clin Management Unit Mental Hlth, Reg Hosp Malaga, Andalusian Hlth Serv, Plaza Hosp, Malaga 29009, Spain.
   [Moreno-Kustner, Berta] Univ Malaga, Biomed Res Inst Malaga IBIMA, Dept Personal Assessment & Psychol Treatment, Fac Psychol,Andalusian Grp Psychosocial Res GAP, Campus Teatinos, Malaga 29071, Spain.
C3 Universidad de Malaga; Universidad de Malaga; Instituto de Investigacion
   Biomedica de Malaga y Plataforma en Nanomedicina (IBIMA); Universidad de
   Malaga; Instituto de Investigacion Biomedica de Malaga y Plataforma en
   Nanomedicina (IBIMA); Universidad de Malaga
RP Castillejos, MC (corresponding author), Univ Malaga, Fac Psychol, Dept Personal Assessment & Psychol Treatment, Andalusian Grp Psychosocial Res GAP, Campus Teatinos, Malaga 29071, Spain.
EM mccasang@gmail.com
RI mayoral, fermin/C-2652-2013
OI Mayoral-Cleries, Fermin/0000-0002-9710-9672; Castillejos
   Anguiano/0000-0001-7943-6584
FU Consejeria de Economia, Innovacion, Ciencia y Empleo, Junta de Andalucia
   [P10-CTS-5862, CTS-945]; Fundacion Progreso y Salud [PI-0193/2014]
FX This project was funded by Consejeria de Economia, Innovacion, Ciencia y
   Empleo, Junta de Andalucia (Award Number: P10-CTS-5862, CTS-945) and
   Fundacion Progreso y Salud (Award Number: PI-0193/2014).
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NR 31
TC 2
Z9 2
U1 0
U2 1
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1744-859X
J9 ANN GEN PSYCHIATR
JI Ann. Gen. Psychiatr.
PD MAY 19
PY 2020
VL 19
IS 1
AR 34
DI 10.1186/s12991-020-00284-5
PG 8
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA LS9CT
UT WOS:000536677300001
PM 32467716
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Ho, J
   Panagiotopoulos, C
   McCrindle, B
   Grisaru, S
   Pringsheim, T
AF Ho, Josephine
   Panagiotopoulos, Constadina
   McCrindle, Brian
   Grisaru, Silviu
   Pringsheim, Tamara
CA Canadian Alliance Monitoring Effec
TI Management recommendations for metabolic complications associated with
   second-generation antipsychotic use in children and youth
SO PAEDIATRICS & CHILD HEALTH
LA English
DT Article
DE Antipsychotic medications; Children; Metabolic syndrome
ID PLACEBO-CONTROLLED TRIAL; WEIGHT-GAIN; DOUBLE-BLIND; PEDIATRIC-PATIENTS;
   CLINICAL-PRACTICE; CARDIOVASCULAR-DISEASE; SCIENTIFIC STATEMENT;
   METFORMIN TREATMENT; ADOLESCENTS; RISPERIDONE
AB BACKGROUND: Second-generation antipsychotics are commonly associated with metabolic complications. These medications are being used more frequently for the treatment of mental health disorders in children, which has stimulated the need for creating formal guidelines on monitoring their safety and effectiveness. Previous guidelines have been developed for monitoring metabolic and neurological complications. To assist practitioners who perform these monitoring procedures, a complementary set of treatment recommendations have been created for situations in which abnormal measurements or results are encountered.
   OBJECTIVE: To create evidence-based recommendations to assist in managing metabolic complications in children being treated with second-generation antipsychotics.
   METHODS: A systematic review of the literature on metabolic complications of second-generation antipsychotic medications in children was conducted. Members of the consensus group evaluated the information gathered from the systematic review of the literature and used a nominal group process to reach a consensus on treatment recommendations. Wherever possible, references were made to existing guidelines on the evaluation and treatment of metabolic abnormalities in children.
   RESULTS: Evidence-based recommendations are presented to assist in managing metabolic complications including weight gain; increased waist circumference; elevation in prolactin, cholesterol, triglyceride and glucose levels; abnormal liver function tests and abnormal thyroid studies.
   CONCLUSION: The use of second-generation antipsychotics requires proper monitoring procedures. The present treatment guideline provides guidance to clinicians on the clinical management of metabolic complications if they occur.
C1 [Ho, Josephine; Grisaru, Silviu] Univ Calgary, Dept Pediat, Calgary, AB T3B 6A8, Canada.
   [Panagiotopoulos, Constadina] Univ British Columbia, Dept Pediat, Vancouver, BC V6T 1W5, Canada.
   [McCrindle, Brian] Univ Toronto, Dept Pediat, Toronto, ON, Canada.
   [Pringsheim, Tamara] Univ Calgary, Dept Clin Neurosci & Pediat, Calgary, AB T3B 6A8, Canada.
C3 University of Calgary; University of British Columbia; University of
   Toronto; University of Calgary
RP Pringsheim, T (corresponding author), Univ Calgary, Alberta Childrens Hosp, Dept Clin Neurosci & Pediat, C4-431,2888 Shaganappi Trail NW, Calgary, AB T3B 6A8, Canada.
EM tmprings@ucalgary.ca
RI Pringsheim, Tamara/L-5955-2019; Panagiotopoulos,
   Constadina/AAO-6827-2020; Patten, Scott/B-4434-2011
OI Patten, Scott/0000-0001-9871-4041; Panagiotopoulos,
   Constadina/0000-0002-1379-7472
FU Canadian Institutes of Health Research; Child AMP; Family Research
   Institute; Canadian Diabetes Association
FX The CAMESA guideline project was funded by the Canadian Institutes of
   Health Research. Dr Panagiotopoulos receives Clinician Scientist salary
   support from the Child & Family Research Institute and the Canadian
   Diabetes Association.
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NR 30
TC 34
Z9 35
U1 0
U2 4
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1205-7088
EI 1918-1485
J9 PAED CHILD HEALT-CAN
JI Paediatr. Child Health
PD NOV
PY 2011
VL 16
IS 9
BP 575
EP 580
DI 10.1093/pch/16.9.575
PG 6
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA 843GJ
UT WOS:000296660000017
PM 23115501
OA Bronze
DA 2025-06-11
ER

PT J
AU Celikbilek, A
   Celikbilek, M
   Bozkurt, G
AF Celikbilek, Asuman
   Celikbilek, Mehmet
   Bozkurt, Gurbet
TI Cognitive assessment of patients with nonalcoholic fatty liver disease
SO EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
LA English
DT Article
DE cognitive dysfunction; executive functioning; Montreal Cognitive
   Assessment; nonalcoholic fatty liver disease; visuospatial domain
ID METABOLIC SYNDROME; ALZHEIMERS-DISEASE; NEUROTROPHIC FACTOR; NORTHERN
   MANHATTAN; IMPAIRMENT; PERFORMANCE; MANAGEMENT; DISORDERS; OBESITY;
   MEMORY
AB Objective The aim of this study was to investigate cognitive performance for the first time in participants with nonalcoholic fatty liver disease (NAFLD) using the Montreal Cognitive Assessment (MoCA).
   Participants and methods In total, 70 participants with NAFLD and 73 age-matched and sex-matched healthy participants were enrolled in this prospective cross-sectional study. The diagnosis of NAFLD was made on the basis of abdominal ultrasonography findings. Anthropometric indices were calculated, and routine laboratory analyses were carried out for each participant. All participants provided sociodemographic data and completed the Beck Depression Inventory-II. Cognitive functions were evaluated using the Turkish version of the MoCA, with a cut-off score for mild cognitive impairment of less than 21 points.
   Results The MoCA scores were significantly lower in participants with NAFLD than in the healthy group (P<0.05). In addition, more NAFLD participants than healthy participants presented with deficits in the visuospatial (P<0.05) and executive function domains (P<0.05). In the multivariate model, education level [2.79 (1.12-6.96); P<0.05] and area of residence [5.68 (2.24-14.38); P < 0.001] were associated independently with cognitive dysfunction in both the NAFLD and the healthy groups. The MoCA scores were correlated negatively with fibrosis 4 scores in NAFLD participants (r=-0.359; P<0.05). However, hepatosteatosis grade and the presence of metabolic syndrome were not correlated with MoCA scores in the NAFLD group (P>0.05).
   Conclusion Our results show that NAFLD patients may have early or subtle cognitive dysfunction, including in the visuospatial and executive function domains, as indexed by scores on the MoCA test. Further targeted psychometric testing will be required to confirm the presence of cognitive impairment in this population. Copyright (C) 2018 Wolters Kluwer Health, Inc. All rights reserved.
C1 [Celikbilek, Asuman] Bozok Univ, Sch Med, Dept Neurol, TR-66200 Yozgat, Turkey.
   [Celikbilek, Mehmet] Bozok Univ, Sch Med, Dept Gastroenterol, Yozgat, Turkey.
   [Bozkurt, Gurbet] Bozok Univ, Sch Med, Dept Psychol, Yozgat, Turkey.
C3 Bozok University; Bozok University; Bozok University
RP Celikbilek, A (corresponding author), Bozok Univ, Sch Med, Dept Neurol, TR-66200 Yozgat, Turkey.
EM asunebioglu@yahoo.com
RI Celikbilek, Mehmet/H-6977-2013
OI Celikbilek, Mehmet/0000-0001-8890-3885; Celikbilek,
   Asuman/0000-0002-2367-1128
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NR 52
TC 52
Z9 57
U1 3
U2 8
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0954-691X
EI 1473-5687
J9 EUR J GASTROEN HEPAT
JI Eur. J. Gastroenterol. Hepatol.
PD AUG
PY 2018
VL 30
IS 8
BP 944
EP 950
DI 10.1097/MEG.0000000000001131
PG 7
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Gastroenterology & Hepatology
GA GM9AS
UT WOS:000438533500024
PM 29608442
DA 2025-06-11
ER

PT J
AU Paternain, L
   García-Diaz, DF
   Milagro, FI
   González-Muniesa, P
   Martinez, JA
   Campión, J
AF Paternain, L.
   Garcia-Diaz, D. F.
   Milagro, F. I.
   Gonzalez-Muniesa, P.
   Martinez, J. A.
   Campion, J.
TI Regulation by chronic-mild stress of glucocorticoids, monocyte
   chemoattractant protein-1 and adiposity in rats fed on a high-fat diet
SO PHYSIOLOGY & BEHAVIOR
LA English
DT Article
DE Stress; Glucocorticoids; Corticosterone; Obesity; High-fat diet; MCP-1;
   Inflammation
ID 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1; GENE-EXPRESSION;
   BODY-WEIGHT; MATERNAL SEPARATION; INSULIN-RESISTANCE; METABOLIC
   SYNDROME; VISCERAL OBESITY; TISSUE; CORTICOSTERONE; RESPONSES
AB Stress has been reported as a widespread problem and several studies have linked obesity and inflammation-related diseases. Moreover, the combination of suffering from chronic stress and high energy intake might be related to the onset of some metabolic diseases. To study the possible relationships between stress, inflammatory status and obesity, a chronic-mild stress (CMS) paradigm with a high-fat dietary intake model (Cafeteria diet) was implemented on male Wistar rats for 11 weeks. Stress and dietary intake effects on animal adiposity, serum biochemical as well as glucocorticoids and inflammation markers were all analyzed. As expected, consuming a high-fat diet increased body weight, adiposity and insulin resistance in non-stressed animals. A decrease of total white adipose tissue (WAT) and an increase of fecal glucocorticoids, as well as angiotensinogen, and monocyte chemoattractant protein-1 (MCP-1) expression level in retroperitoneal WAT were found only on control-stressed rats. Regarding the serum MCP-1, a decrease was observed on animals under CMS while being fed Cafeteria diet. Furthermore, 11 beta-hidroxysteroid dehydrogenase activity, a glucocorticoid and obesity biomarker in the liver, was influenced by high-fat diet intake but not by stress. Finally, statistical analysis showed a strong relation between MCP-1 expression levels in retroperitoneal WAT, fecal corticosterone and total WAT. This trial proved that CMS induced a glucocorticoid-mediated response, which was reduced by the intake of a Cafeteria diet. These findings suggest that a high-fat diet could protect against a stress condition and revealed a different behavior to a stressful environment depending on the nutritional status. (C) 2011 Elsevier Inc. All rights reserved.
C1 [Paternain, L.; Garcia-Diaz, D. F.; Milagro, F. I.; Gonzalez-Muniesa, P.; Martinez, J. A.; Campion, J.] Univ Navarra, Dept Nutr & Food Sci Physiol & Toxicol, Pamplona 31008, Spain.
C3 University of Navarra
RP Campión, J (corresponding author), Univ Navarra, Dept Nutr & Food Sci Physiol & Toxicol, C Irunlarrea 1, Pamplona 31008, Spain.
EM jcampion@unav.es
RI Milagro, Fermin/F-2315-2015; Paternain, Laura/AAB-3917-2020; Garcia,
   Diego/AGH-4056-2022; Gonzalez-Muniesa, Pedro/H-2158-2015; Martinez
   Hernandez, J Alfredo/K-8709-2014
OI Paternain, Laura/0000-0002-1119-5232; Campion,
   Javier/0000-0002-6522-8271; Gonzalez-Muniesa, Pedro/0000-0002-3130-2496;
   Garcia-Diaz, Diego/0000-0002-7551-0553; Milagro, Fermin
   I./0000-0002-3228-9916; Martinez Hernandez, J
   Alfredo/0000-0001-5218-6941
FU University of Navarra, Navarra Government [LE/97]; Comunidad de Trabajo
   de los Pirineos CTP (Navarra); Department of Education of the Government
   of Navarra
FX The authors wish to thank Linea Especial (LE/97) from the University of
   Navarra, Navarra Government funds from 2000, as well as to the Comunidad
   de Trabajo de los Pirineos CTP (Navarra) and Department of Education of
   the Government of Navarra for financial support We also appreciate the
   careful reading and correction of the last version by Brianna Cole for
   English quality.
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NR 87
TC 22
Z9 22
U1 0
U2 12
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0031-9384
EI 1873-507X
J9 PHYSIOL BEHAV
JI Physiol. Behav.
PD MAY 3
PY 2011
VL 103
IS 2
BP 173
EP 180
DI 10.1016/j.physbeh.2011.01.017
PG 8
WC Psychology, Biological; Behavioral Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Behavioral Sciences
GA 756KY
UT WOS:000290011300007
PM 21262246
DA 2025-06-11
ER

PT J
AU McCullough, D
   Webb, R
   Enright, KJ
   Lane, KE
   McVeigh, J
   Stewart, CE
   Davies, IG
AF McCullough, Deaglan
   Webb, Richard
   Enright, Kevin J.
   Lane, Katie E.
   McVeigh, Jim
   Stewart, Claire E.
   Davies, Ian G.
TI How the love of muscle can break a heart: Impact of anabolic androgenic
   steroids on skeletal muscle hypertrophy, metabolic and cardiovascular
   health
SO REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
LA English
DT Article
DE Anabolic-androgenic steroids; Metabolic syndrome; High-density
   lipoprotein cholesterol; Low-density lipoprotein cholesterol; Insulin
   resistance; Cardiovascular disease
ID POLYCYSTIC-OVARY-SYNDROME; VISCERAL ADIPOSE-TISSUE; INSULIN-RESISTANCE;
   BLOOD-PRESSURE; NANDROLONE DECANOATE; TESTOSTERONE TREATMENT;
   LIPOPROTEIN PROFILES; ATHEROSCLEROSIS RISK; INDUCED HYPOGONADISM;
   ARTERIAL STIFFNESS
AB It is estimated 6.4% of males and 1.6% of females globally use anabolic-androgenic steroids (AAS), mostly for appearance and performance enhancing reasons. In combination with resistance exercise, AAS use increases muscle protein synthesis resulting in skeletal muscle hypertrophy and increased performance. Primarily through binding to the androgen receptor, AAS exert their hypertrophic effects via genomic, non-genomic and anti-catabolic mechanisms. However, chronic AAS use also has a detrimental effect on metabolism ultimately increasing the risk of cardiovascular disease (CVD). Much research has focused on AAS effects on blood lipids and lipoproteins, with abnormal concentrations of these associated with insulin resistance, hypertension and increased visceral adipose tissue (VAT). This clustering of interconnected abnormalities is often referred as metabolic syndrome (MetS). Therefore, the aim of this review is to explore the impact of AAS use on mechanisms of muscle hypertrophy and markers of MetS. AAS use markedly decreases high-density lipoprotein cholesterol (HDL-C) and increases low-density lipoprotein cholesterol (LDL-C). Chronic AAS use also appears to cause higher fasting insulin levels and impaired glucose tolerance and possibly higher levels of VAT; however, research is currently lacking on the effects of AAS use on glucose metabolism. While cessation of AAS use can restore normal lipid levels, it may lead to withdrawal symptoms such as depression and hypogonadism that can increase CVD risk. Research is currently lacking on effective treatments for withdrawal symptoms and further long-term research is warranted on the effects of AAS use on metabolic health in males and females.
C1 [McCullough, Deaglan; Enright, Kevin J.; Lane, Katie E.; Stewart, Claire E.; Davies, Ian G.] Liverpool John Moores Univ, Res Inst Sport & Exercise Sci, Liverpool, Merseyside, England.
   [Webb, Richard] Liverpool Hope Univ, Fac Sci, Liverpool, Merseyside, England.
   [McVeigh, Jim] Manchester Metropolitan Univ, Subst Use & Associated Behav Grp, Manchester, Lancs, England.
C3 Liverpool John Moores University; Liverpool Hope University; Manchester
   Metropolitan University
RP McCullough, D; Davies, IG (corresponding author), Liverpool John Moores Univ, Res Inst Sport & Exercise Sci, Liverpool, Merseyside, England.
EM d.mccullough@2015.ljmu.ac.uk; I.G.Davies@ljmu.ac.uk
RI McCullough, Deaglan/AAD-1205-2022; Stewart, Claire/JCE-2163-2023;
   Davies, Ian/AAP-8249-2021; Lane, Katie/MHP-9478-2025; Enright,
   Kevin/S-8641-2019; McVeigh, Jim/O-7851-2019; Enright, Kevin/A-5349-2011
OI Lane, Katie/0000-0002-9092-2927; Enright, Kevin/0000-0003-1775-6392;
   Davies, Ian/0000-0003-3722-8466; Webb, Richard/0000-0001-9591-585X;
   Stewart, Claire/0000-0002-8104-4819; McCullough,
   Deaglan/0000-0002-9882-9639; McVeigh, Jim/0000-0001-5319-6885
FU Liverpool John Moores University
FX Deaglan McCullough received funding for a PhD studentship by Liverpool
   John Moores University.
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NR 180
TC 25
Z9 27
U1 1
U2 12
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1389-9155
EI 1573-2606
J9 REV ENDOCR METAB DIS
JI Rev. Endocr. Metab. Disord.
PD JUN
PY 2021
VL 22
IS 2
BP 389
EP 405
DI 10.1007/s11154-020-09616-y
EA DEC 2020
PG 17
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA RV9MX
UT WOS:000595397900001
PM 33269425
OA Green Accepted, Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Santilli, F
   Guagnano, MT
   Vazzana, N
   La Barba, S
   Davì, G
AF Santilli, F.
   Guagnano, M. T.
   Vazzana, N.
   La Barba, S.
   Davi, G.
TI Oxidative Stress Drivers and Modulators in Obesity and Cardiovascular
   Disease: From Biomarkers to Therapeutic Approach
SO CURRENT MEDICINAL CHEMISTRY
LA English
DT Article
DE Biomarker; inflammation; obesity; oxidative stress; platelet activation
ID GLYCATION END-PRODUCTS; ENDOGENOUS SECRETORY RAGE; NITRIC-OXIDE
   SYNTHASE; PLATELET ACTIVATION; ENDOTHELIAL DYSFUNCTION;
   MOLECULAR-MECHANISMS; SUBCUTANEOUS ADIPOSE; LIPID-PEROXIDATION; PRIMARY
   PREVENTION; METABOLIC SYNDROME
AB This review article is intended to describe how oxidative stress regulates cardiovascular disease development and progression. Epigenetic mechanisms related to oxidative stress, as well as more reliable biomarkers of oxidative stress, are emerging over the last years as potentially useful tools to design therapeutic approaches aimed at modulating enhanced oxidative stress "in vivo", thereby mitigating the consequent atherosclerotic burden. As a paradigm, we describe the case of obesity, in which the intertwining among oxidative stress, due to caloric overload, chronic low-grade inflammation induced by adipose tissue dysfunction, and platelet activation represents a vicious cycle favoring the progression of atherothrombosis. Oxidative stress is a major player in the pathobiology of cardiovascular disease (CVD). Reactive oxygen species (ROS)-dependent signaling pathways prompt transcriptional and epigenetic dysregulation, inducing chronic low-grade inflammation, platelet activation and endothelial dysfunction. In addition, several oxidative biomarkers have been proposed with the potential to improve current understanding of the mechanisms underlying CVD. These include ROS-generating and/or quenching molecules, and ROS-modified compounds, such as F-2-isoprostanes. There is also increasing evidence that noncoding micro- RNA (mi-RNA) are critically involved in post-transcriptional regulation of cell functions, including ROS generation, inflammation, regulation of cell proliferation, adipocyte differentiation, angiogenesis and apoptosis. These molecules have promising translational potential as both markers of disease and site of targeted interventions. Finally, oxidative stress is a critical target of several cardioprotective drugs and nutraceuticals, including antidiabetic agents, statins, renin-angiotensin system blockers, polyphenols and other antioxidants. Further understanding of ROS-generating mechanisms, their biological role as well as potential therapeutic implications would translate into consistent benefits for effective CV prevention.
C1 [Santilli, F.; Guagnano, M. T.; Vazzana, N.; La Barba, S.; Davi, G.] Univ G dAnnunzio, Ctr Excellence Aging, I-66013 Chieti, Italy.
C3 G d'Annunzio University of Chieti-Pescara
RP Davì, G (corresponding author), Univ G dAnnunzio, Ctr Excellence Aging, Via Colle Ara, I-66013 Chieti, Italy.
EM gdavi@unich.it
RI GUAGNANO, MARIA TERESA/AAT-1701-2021; Davì, Giovanni/K-7659-2016;
   Santilli, Francesca/ABC-6243-2021
OI Santilli, Francesca/0000-0002-4593-905X
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NR 118
TC 66
Z9 69
U1 1
U2 34
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 0929-8673
EI 1875-533X
J9 CURR MED CHEM
JI Curr. Med. Chem.
PY 2015
VL 22
IS 5
BP 582
EP 595
DI 10.2174/0929867322666141128163739
PG 14
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Pharmacology &
   Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
GA CB1KW
UT WOS:000349387200004
PM 25439585
DA 2025-06-11
ER

PT J
AU Al Lawati, I
   Zadjali, F
   Al-Abri, MA
AF Al Lawati, Ibtisam
   Zadjali, Fahad
   Al-Abri, Mohammed A.
TI Elevated oxidative stress biomarkers in adults with segmented sleep
   patterns
SO JOURNAL OF CLINICAL SLEEP MEDICINE
LA English
DT Article
DE stress biomarkers sleep patterns; actigraphy; inflammation markers;
   oxidative stress markers
ID C-REACTIVE PROTEIN; CARDIOVASCULAR RISK; METABOLIC SYNDROME; REDUCED
   SLEEP; DURATION; INFLAMMATION; MARKERS; QUALITY; BLOOD; ZINC
AB Study Objectives: We investigated the association between different sleep patterns and inflammatory and oxidative stress biomarkers in adults. Methods: A total of 321 consented adults who fulfilled the inclusion criteria were recruited in this cross-sectional study. The inclusion criteria were mainly based on apparently healthy adults aged 18-59 years. To identify sleep patterns, participants were requested to wear the actigraph for 1 week for 24 hours a day. Fasting blood was collected from each participant at day 8. The blood serum was analyzed for inflammatory and oxidative stress biomarkers. Sleep patterns were defined as monophasic (1 episode of night sleep) biphasic (2 episodes of sleep; night and aternoon siesta), and polyphasic sleep pattern (3 or more sleep episodes). Results: There was no correlation between night sleep duration, total sleep in 24 hours, and napping among inflammatory and oxidative stress biomarkers: high-sensitivity C-reactive protein, malondialdehyde, total glutathione, and basal oxidizability status. Actigraphy reports showed 3 sleep patterns in this cohort, monophasic (24.3%), biphasic-napping (45.2%) and polyphasic (30.5%). Individuals with segmented sleep patterns were significantly associated with oxidative stress biomarkers. A polyphasic sleep pattern was significantly associated with higher basal oxidizability status (P = .023), whereas a biphasic sleep pattern showed higher malondialdehyde (P = .036) as compared to a monophasic sleep pattern. Total glutathione was significantly higher in monophasic sleepers (P = .046). There was no difference in serum high-sensitivity C-reactive protein among all sleep patterns. Conclusions: Segmented sleep in polyphasic and biphasic sleep patterns is associated with higher serum malondialdehyde and basal oxidizability status in particular. Further studies are recommended on the cardiometabolic impact of oxidative stress biomarkers in individuals with segmented sleep. Citation: Al Lawati I, Zadjali F, Al-Abri MA. Elevated oxidative stress biomarkers in adults with segmented sleep patterns. J Clin Sleep Med. 2024;20(6):959-966.
C1 [Al Lawati, Ibtisam] Oman Coll Hlth Sci, Dept Support Sci, Muscat, Bousher, Oman.
   [Zadjali, Fahad] Sultan Qaboos Univ, Dept Clin Biochem, Muscat, Khoud, Oman.
   [Al-Abri, Mohammed A.] Sultan Qaboos Univ, Dept Physiol & Clin Physiol, Muscat, Khoud, Oman.
C3 Sultan Qaboos University; Sultan Qaboos University
RP Al-Abri, MA (corresponding author), Sultan Qaboos Univ, Dept Physiol & Clin Physiol, Muscat, Khoud, Oman.
EM malabri@squ.edu.om
RI ZADJALI, FAHAD/B-5091-2019
FU Research Council of Oman [RC/MED/PHYS/15/01]
FX <BOLD> All authors read and approved the final manuscript. This study
   was funded by grant number RC/MED/PHYS/15/01 from the Research Council
   of Oman. The authors report no conflicts of interest. </BOLD> The
   authors express our sincere gratitude to the Research Council of Oman
   for funding this research project. All authors contributed to the study
   conception and design. Material preparation, data collection, and
   analysis were performed by all authors. The first draft of the
   manuscript was written by Ibtisam Al Lawati and all authors commented on
   previous versions of the manuscript.
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NR 41
TC 0
Z9 0
U1 2
U2 2
PU AMER ACAD SLEEP MEDICINE
PI DARIEN
PA 2510 N FRONTAGE RD, DARIEN, IL 60561 USA
SN 1550-9389
EI 1550-9397
J9 J CLIN SLEEP MED
JI J. Clin. Sleep Med.
PD JUN 1
PY 2024
VL 20
IS 6
BP 1
EP 8
PG 8
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA UQ6U6
UT WOS:001249571200002
DA 2025-06-11
ER

PT J
AU Dai, F
   Jiang, T
   Bao, YY
   Chen, GJ
   Chen, L
   Zhang, Q
   Lu, YX
AF Dai, Fang
   Jiang, Tian
   Bao, Ying-ying
   Chen, Guan-jun
   Chen, Li
   Zhang, Qiu
   Lu, Yun-xia
TI Fenofibrate improves high-fat diet-induced and palmitate-induced
   endoplasmic reticulum stress and inflammation in skeletal muscle
SO LIFE SCIENCES
LA English
DT Article
DE Fenofibrate; Skeletal muscle; Lipids; Insulin resistance; Endoplasmic
   reticulum stress; Inflammation
ID INSULIN-RESISTANCE; PPAR-ALPHA; METABOLIC SYNDROME; ACID; CELLS;
   MITOCHONDRIAL; ADIPOCYTES; INHIBITION; EXPRESSION; STEATOSIS
AB Aims: Fenofibrate (FF) is commonly used clinically as a lipid-lowering drug, but whether it participates in endoplasmic reticulum (ER) stress and decreases inflammation in skeletal muscle is still unknown. The aim of this study is to determine whether FF treatment reduces insulin resistance (IR) by alleviating ER stress and downstream inflammation in skeletal muscle tissues and cells.
   Main methods: Female SD rats were randomly divided into groups receiving the standard chow diet (SCD), a high-fat diet (HFD), or HFD plus FF (HFD + FF). The rats in the latter two groups were subjected to a standard HFD for 20 weeks, then the HFD + FF rats were administered FF (30 mg/kg once daily via gavage) for another 8 weeks. Whole-body IR, expression of peroxisome proliferator-activated receptor alpha (PPAR alpha), ER stress-related genes, and inflammatory genes in the soleus muscle were assessed. The differentiated C2C12 myotubes were treated with palmitic acid or pretreated with fenofibric acid or 4-phenylbutyric acid (4-PBA), etomoxir, and the expression of ER stress, beta-oxidation-related genes, inflammatory genes, Toll-like receptor 4 (TLR4), and insulin-signaling-related molecules were determined.
   Key findings: Eight weeks of FF treatment attenuated HFD-induced IR by decreased tribbles 3 (TRB3) expression, ER stress and inflammation in skeletal muscle. FA pretreatment markedly inverted the PA-induced expression of TLR4 and downstream inflammatory genes, activated ER stress, improved beta-oxidation and insulin signaling in differentiated myotube cells.
   Significance: FF treatment significantly improved HFD-induced IR in skeletal muscle and PA-induced IR in myotube cells, which may be related to reduced ER stress-induced inflammation. (C) 2016 Elsevier Inc. All rights reserved.
C1 [Dai, Fang; Jiang, Tian; Bao, Ying-ying; Zhang, Qiu] Anhui Med Univ, Affiliated Hosp 1, Dept Endocrinol, 218 Jixi Rd, Hefei 230022, Peoples R China.
   [Chen, Guan-jun; Lu, Yun-xia] Anhui Med Univ, Dept Biochem & Mol Biol, 81 Meishan Rd, Hefei 230032, Anhui, Peoples R China.
   [Lu, Yun-xia] Anhui Med Univ, Comprehens Lab, Hefei 230032, Peoples R China.
   [Chen, Li] Anhui Prov Hosp, Dept Lab Med, Hefei 230001, Peoples R China.
C3 Anhui Medical University; Anhui Medical University; Anhui Medical
   University
RP Zhang, Q (corresponding author), Anhui Med Univ, Affiliated Hosp 1, Dept Endocrinol, 218 Jixi Rd, Hefei 230022, Peoples R China.; Lu, YX (corresponding author), Anhui Med Univ, Dept Biochem & Mol Biol, 81 Meishan Rd, Hefei 230032, Anhui, Peoples R China.
EM aynfmkqz87@163.com; wwwdluyx@sina.com
RI Guanjun, Chen/AAN-1550-2021; Lu, Yunxia/AAU-6408-2021
OI Zhang, Qiu/0000-0002-7470-5543
FU Anhui Medical University for Scientific Research of BSKY [XJ201013];
   Fund of Anhui Natural Science Foundation of China [1608085MH208,
   1308085MH154]
FX This work was supported by research grants from Anhui Medical University
   for Scientific Research of BSKY (XJ201013) and the Fund of Anhui Natural
   Science Foundation of China (1608085MH208 and 1308085MH154). Part of
   this work was carried out at the Department of Parasitology, Anhui
   Medical University. The authors are in debt to Cuiping Ren for technical
   assistance.
CR Abildgaard J, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0101555
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NR 29
TC 24
Z9 26
U1 1
U2 12
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0024-3205
EI 1879-0631
J9 LIFE SCI
JI Life Sci.
PD JUL 15
PY 2016
VL 157
BP 158
EP 167
DI 10.1016/j.lfs.2016.06.008
PG 10
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA DW3CS
UT WOS:000383520300023
PM 27297630
DA 2025-06-11
ER

PT J
AU Tahmasbi, F
   Araj-Khodaei, M
   Mahmoodpoor, A
   Sanaie, S
AF Tahmasbi, Fateme
   Araj-Khodaei, Mostafa
   Mahmoodpoor, Ata
   Sanaie, Sarvin
TI Effects of saffron (Crocus sativus L.) on anthropometric and
   cardiometabolic indices in overweight and obese patients: A systematic
   review and meta-analysis of randomized controlled trials
SO PHYTOTHERAPY RESEARCH
LA English
DT Review
DE Crocus sativus; meta-analysis; obesity; overweight; saffron; systematic
   review
ID TYPE-2 DIABETES-MELLITUS; DOUBLE-BLIND; METABOLIC SYNDROME;
   BODY-COMPOSITION; SUPPLEMENTATION; EXTRACT; ANTIOXIDANT; DEPRESSION;
   CONSTITUENTS; INFLAMMATION
AB The worldwide prevalence of obesity is approximately tripled between 1975 and 2016 according to World Health Organization; therefore, obesity is now considered a global pandemic that needs academic and clinical focus. In search of antiobesity agents, Crocus sativus, known widely as saffron, has been praised for its beneficial effects. Several randomized controlled trials (RCTs) have been conducted to investigate the weight lowering effect of saffron. Following PRISMA guidelines, several medical databases were comprehensively searched for RCTs with a population consisting of obese individuals. A random-effects meta-analysis was used to pool estimates across studies, and standardized mean difference (SMD) was used to synthesize quantitative results. Twenty-five RCTs met the inclusion criteria. Meta-analysis showed a nonsignificant decrease for weight (-0.32 kg; CI: -3.15, 2.51; p = 0.82), BMI (-0.06 kg/m(2);CI:-1.04,0.93; p = .91), waist circumference (-1.23 cm; CI: -4.14, 1.68; p = .41), and hip circumference (-0.38 cm; CI: -5.99, 5.23; p = .89) and a significant decrease of waist-to-hip ratio (SMD = -0.41; CI: -0.73, -0.09; p = .01; I-2 = 0%). The mean difference in fasting blood sugar showed a significant reduction in patients with metabolic syndrome (SMD = -0.30; 95% CI: -0.63, 0.03; p = .07; I-2 = 0.37%) but a nonsignificant change in the HbA1C level (WMD = 0.05; 95% CI: 0.32, 0.41; p = .79). Despite bearing several limitations, mainly as a result of heterogeneity among included studies, the available evidence indicates saffron supplementation shows promising effects on some cardiometabolic factors among overweight to obese patients; however, further investigations and high-quality evidence are required for more generalizable and comprehensive results.
C1 [Tahmasbi, Fateme] Tabriz Univ Med Sci, Student Res Comm, Tabriz, Iran.
   [Tahmasbi, Fateme; Araj-Khodaei, Mostafa; Sanaie, Sarvin] Tabriz Univ Med Sci, Res Ctr Integrat Med Aging, Aging Res Inst, Tabriz, Iran.
   [Araj-Khodaei, Mostafa] Tabriz Univ Med Sci, Fac Persian Med, Dept Persian Med, Tabriz, Iran.
   [Mahmoodpoor, Ata] Tabriz Univ Med Sci, Fac Med, Anesthesiol & Crit Care Dept, Tabriz, Iran.
C3 Tabriz University of Medical Science; Tabriz University of Medical
   Science; Tabriz University of Medical Science; Tabriz University of
   Medical Science
RP Sanaie, S (corresponding author), Tabriz Univ Med Sci, Fac Med, Aging Res Inst, Golgasht St, Tabriz, Iran.
EM sarvin_so2000@yahoo.com
RI mahmoodpoor, ata/AAR-9972-2021; Araj-Khodaei, Mostafa/AAA-2220-2022;
   Tahmasbi, Fateme/ABC-9030-2021; Sanaie, Sarvin/I-3769-2016
OI Sanaie, Sarvin/0000-0003-2325-5631; mahmoodpoor,
   Ata/0000-0002-4361-6230; Tahmasbi, Fateme/0000-0002-0652-7693
FU Tabriz University of Medical Sciences [67486]
FX Tabriz University of Medical Sciences, Grant/Award Number: 67486
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TC 7
Z9 7
U1 2
U2 8
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0951-418X
EI 1099-1573
J9 PHYTOTHER RES
JI Phytother. Res.
PD SEP
PY 2022
VL 36
IS 9
BP 3394
EP 3414
DI 10.1002/ptr.7530
EA JUL 2022
PG 21
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 4I8OM
UT WOS:000828654400001
PM 35866520
DA 2025-06-11
ER

PT J
AU Kaluzna, M
   Kompf, P
   Wachowiak-Ochmanska, K
   Moczko, J
   Krolczyk, A
   Janicki, A
   Szapel, K
   Grzymislawski, M
   Ruchala, M
   Ziemnicka, K
AF Kaluzna, Malgorzata
   Kompf, Pola
   Wachowiak-Ochmanska, Katarzyna
   Moczko, Jerzy
   Krolczyk, Aleksandra
   Janicki, Adam
   Szapel, Karol
   Grzymislawski, Marian
   Ruchala, Marek
   Ziemnicka, Katarzyna
TI Are patients with polycystic ovary syndrome more prone to irritable
   bowel syndrome?
SO ENDOCRINE CONNECTIONS
LA English
DT Article
DE irritable bowel syndrome (IBS); Rome IV (diagnostic) criteria;
   polycystic ovary syndrome (PCOS); constipation; diarrhea
ID BODY-MASS INDEX; QUALITY-OF-LIFE; INSULIN-RESISTANCE; METABOLIC
   SYNDROME; WOMEN; SYMPTOMS; HEALTH; PREVALENCE; RISK; ATHEROSCLEROSIS
AB Background Polycystic ovary syndrome (PCOS) encompasses endocrine, reproductive and metabolic disturbances. Abdominal pain and bowel movement disturbances are common complaints of PCOS patients. It remains uncertain whether the characteristic features of PCOS are associated with an increased incidence of irritable bowel syndrome (IBS). Methods In the study, 133 patients with PCOS diagnosed according to international evidence-based guidelines and 72 age- and BMI-matched eumenorrheic controls were enrolled. Anthropometric measurements and biochemical and hormonal characteristics were collected. The Rome IV criteria were used for IBS diagnosis. Quality of life (QoL) and depressive symptoms were also assessed. Results IBS symptom prevalence in PCOS was not significantly different than in controls. Hyperandrogenism and simple and visceral obesity did not appear to affect IBS prevalence in PCOS. There were no anthropometric, hormonal or biochemical differences between IBS-PCOS and non-IBS-PCOS patients, apart from IBS-PCOS patients being slightly older and having lower thyroid-stimulating hormone. Metabolic syndrome (MS) prevalence was higher in IBS-PCOS than non-IBS-PCOS. QoL appears to be significantly lower in IBS-PCOS compared to PCOS-only patients. The occurrence of depression was higher in IBS-PCOS vs non-IBS-PCOS patients. At least one alarm symptom was reported by 87.5% of IBS-PCOS; overall, this group experienced more alarm symptoms than the IBS-only group. Conclusions Since a link between PCOS and IBS comorbidity and increased MS prevalence was noted, patients presenting with both conditions may benefit from early MS diagnostics and management. The high incidence of alarm symptoms in PCOS women in this study highlights the need for differential diagnosis of organic diseases that could mimic IBS symptoms.
C1 [Kaluzna, Malgorzata; Kompf, Pola; Janicki, Adam; Ruchala, Marek; Ziemnicka, Katarzyna] Poznan Univ Med Sci, Dept Endocrinol Metab & Internal Med, Poznan, Poland.
   [Wachowiak-Ochmanska, Katarzyna] Heliodor Swiecicki Clin Hosp, Poznan, Poland.
   [Moczko, Jerzy] Poznan Univ Med Sci, Dept Comp Sci & Stat, Poznan, Poland.
   [Krolczyk, Aleksandra; Grzymislawski, Marian] Poznan Univ Med Sci, Chair & Dept Gastroenterol Dietet & Internal Med, Poznan, Poland.
   [Szapel, Karol] Poznan Univ Med Sci, Dept Physiotherapy, Poznan, Poland.
C3 Poznan University of Medical Sciences; Poznan University of Medical
   Sciences; Poznan University of Medical Sciences; Poznan University of
   Medical Sciences
RP Kaluzna, M (corresponding author), Poznan Univ Med Sci, Dept Endocrinol Metab & Internal Med, Poznan, Poland.
EM mkaluzna@ump.edu.pl
RI Królczyk, Aleksandra/L-3602-2018
OI Ziemnicka, Katarzyna/0000-0001-5377-8834; Kaluzna,
   Malgorzata/0000-0002-2116-4384; Kompf-Wiezel, Pola/0000-0002-3121-3055;
   Moczko, Jerzy Andrzej/0000-0002-4164-6196
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NR 50
TC 9
Z9 9
U1 6
U2 15
PU BIOSCIENTIFICA LTD
PI BRISTOL
PA STARLING HOUSE, 1600 BRISTOL PARKWAY N, BRISTOL, ENGLAND
EI 2049-3614
J9 ENDOCR CONNECT
JI Endocr. Connect.
PD APR 1
PY 2022
VL 11
IS 4
AR e210309
DI 10.1530/EC-21-0309
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 1X2SA
UT WOS:000807308600008
PM 35275093
OA Green Published
DA 2025-06-11
ER

PT J
AU Lee, CY
AF Lee, Chooi Yeng
TI Chronic restraint stress induces intestinal inflammation and alters the
   expression of hexose and lipid transporters
SO CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
LA English
DT Article
DE facilitative glucose transporter-2 (SLC2A2); gut; inflammation;
   Niemann-Pick C1-like-1 (NPC1L1); restraint stress; sodium-dependent
   glucose transporter-1 (SLC5A1)
ID GLUCOSE-ABSORPTION; INDUCED OBESITY; MESSENGER-RNA; NITRIC-OXIDE;
   CHOLESTEROL; MELATONIN; PROTEIN; ADAPTATION; RECEPTORS; MECHANISM
AB Psychosocial stress is reported to be one of the main causes of obesity. Based on observations in studies that relate stress and gut inflammation to obesity, the present study hypothesized that chronic stress, via inflammation, alters the expression of nutrient transporters and contributes to the development of metabolic syndrome. Rats were exposed to restraint stress for 4h/day for 5days/week for eight consecutive weeks. Different segments of rat intestine were then collected and analysed for signs of pathophysiological changes and the expression of Niemann-Pick C1-like-1 (NPC1L1), sodium-dependent glucose transporter-1 (SLC5A1, previously known as SGLT1) and facilitative glucose transporter-2 (SLC2A2, previously known as GLUT2). In a separate experiment, the total anti-oxidant activity (TAA)-time profile of control isolated intestinal segments was measured. Stress decreased the expression of NPC1L1 in the ileum and upregulated SLC5A1 in both the jejunum and ileum and SLC2A2 in the duodenum. Inflammation and morphological changes were observed in the proximal region of the intestine of stressed animals. Compared with jejunal and ileal segments, the rate of increase in TAA was higher in the duodenum, indicating that the segment contained less anti-oxidants; anti-oxidants may function to protect the tissues. In conclusion, stress alters the expression of hexose and lipid transporters in the gut. The site-specific increase in the expression of SLC5A1 and SLC2A2 may be correlated with pathological changes in the intestine. The ileum may be protected, in part, by gut anti-oxidants. Collectively, the data suggest that apart from causing inflammation, chronic stress may promote sugar uptake and contribute to hyperglycaemia.
C1 Monash Univ, Discipline Pharm, Bandar Sunway 46150, Selangor, Malaysia.
C3 Monash University; Monash University Malaysia
RP Lee, CY (corresponding author), Monash Univ, Discipline Pharm, Sunway Campus,Jalan Lagoon Selatan, Bandar Sunway 46150, Selangor, Malaysia.
EM chooi.yeng.lee@monash.edu
RI Lee, Chooi/AAF-7379-2020
OI Lee, Chooi Yeng/0000-0001-5847-0329
FU Monash University Sunway Campus
FX This work was supported by a grant from the Monash University Sunway
   Campus. The author thanks Dr Satoshi Ogawa (Brain Research Institute
   Monash Sunway) for processing and staining of the intestinal tissues.
   The histological evaluations were performed by the Australian Phenomics
   Network Histopathology and Organ Pathology, The University of Melbourne
   (Melbourne, Victoria, Australia). The author also thanks Professor
   Daniel Reidpath (School of Medicine and Health Sciences, Monash
   University Sunway Campus) for his comments on the manuscript.
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NR 38
TC 14
Z9 18
U1 1
U2 14
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0305-1870
EI 1440-1681
J9 CLIN EXP PHARMACOL P
JI Clin. Exp. Pharmacol. Physiol.
PD JUN
PY 2013
VL 40
IS 6
BP 385
EP 391
DI 10.1111/1440-1681.12096
PG 7
WC Pharmacology & Pharmacy; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Physiology
GA 152HP
UT WOS:000319522900007
PM 23586523
DA 2025-06-11
ER

PT J
AU Schellekens, H
   Dinan, TG
   Cryan, JF
AF Schellekens, Harriet
   Dinan, Timothy G.
   Cryan, John F.
TI Taking two to tango: a role for ghrelin receptor heterodimerization in
   stress and reward
SO FRONTIERS IN NEUROSCIENCE
LA English
DT Review
DE ghrelin; dimerization; obesity; stress; food reward
ID PROTEIN-COUPLED RECEPTORS; PITUITARY-ADRENAL AXIS; EARLY-LIFE STRESS;
   HIGH-FAT DIET; HIGH CONSTITUTIVE ACTIVITY; VENTRAL TEGMENTAL AREA;
   CHRONIC SOCIAL STRESS; PSYCHOSOCIAL STRESS; METABOLIC SYNDROME; GPCR
   OLIGOMERIZATION
AB The gut hormone, ghrelin, is the only known peripherally derived orexigenic signal. It activates its centrally expressed receptor, the growth hormone secretagogue receptor (GHS-R1a), to stimulate food intake. The ghrelin signaling system has recently been suggested to play a key role at the interface of homeostatic control of appetite and the hedonic aspects of food intake, as a critical role for ghrelin in dopaminergic mesolimbic circuits involved in reward signaling has emerged. Moreover, enhanced plasma ghrelin levels are associated with conditions of physiological stress, which may underline the drive to eat calorie-dense "comfort-foods" and signifies a role for ghrelin in stress-induced food reward behaviors. These complex and diverse functionalities of the ghrelinergic system are not yet fully elucidated and likely involve crosstalk with additional signaling systems. Interestingly, accumulating data over the last few years has shown the GHS-R1a receptor to dimerize with several additional G-protein coupled receptors (GPCRs) involved in appetite signaling and reward, including the GHS-R1b receptor, the melanocortin 3 receptor (MC3), dopamine receptors (D-1 and D-2), and more recently, the serotonin 2C receptor (5-HT2C). GHS-R1a dimerization was shown to affect downstream signaling and receptor trafficking suggesting a potential novel mechanism for fine-tuning GHS-R1a receptor mediated activity. This review summarizes ghrelin's role in food reward and stress and outlines the GHS-R1a dimer pairs identified to date. In addition, the downstream signaling and potential functional consequences of dimerization of the GHS-R1a receptor in appetite and stress-induced food reward behavior are discussed. The existence of multiple GHS-R1a heterodimers has important consequences for future pharmacotherapies as it significantly increases the pharmacological diversity of the GHS-R1a receptor and has the potential to enhance specificity of novel ghrelin-targeted drugs.
C1 [Schellekens, Harriet; Dinan, Timothy G.; Cryan, John F.] Natl Univ Ireland Univ Coll Cork, Food Hlth Ireland, Cork, Ireland.
   [Dinan, Timothy G.; Cryan, John F.] Natl Univ Ireland Univ Coll Cork, Alimentary Pharmabiot Ctr, Lab Neurogastroenterol, Cork, Ireland.
   [Dinan, Timothy G.] Natl Univ Ireland Univ Coll Cork, Dept Psychiat, Cork, Ireland.
   [Cryan, John F.] Natl Univ Ireland Univ Coll Cork, Dept Anat & Neurosci, Cork, Ireland.
C3 University College Cork; Teagasc; University College Cork; University
   College Cork; University College Cork
RP Cryan, JF (corresponding author), Natl Univ Ireland Univ Coll Cork, Dept Anat & Neurosci, Western Gateway Bldg, Cork, Ireland.
EM j.cryan@ucc.ie
RI Dinan, Timothy/ABA-8284-2020; Cryan, John/A-6950-2013
OI Dinan, Timothy/0000-0002-2316-7220; Cryan, John/0000-0001-5887-2723;
   Schellekens, Harriet/0000-0002-6065-3797
FU Enterprise Ireland [CC20080001]; Science Foundation Ireland (SFI)
   (Alimentary Pharmabiotic Centre) through Irish Government's National
   Development Plan; SFI [02/CE/B124, 07/CE/B1368]
FX The work was supported by Enterprise Ireland under Grant Number
   CC20080001. John F. Cryan and Timothy G. Dinan are also supported in
   part by Science Foundation Ireland (SFI) in the form of a centre grant
   (Alimentary Pharmabiotic Centre) through the Irish Government's National
   Development Plan. The authors and their work were supported by SFI
   (grant numbers 02/CE/B124 and 07/CE/B1368).
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NR 226
TC 70
Z9 78
U1 0
U2 28
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1662-453X
J9 FRONT NEUROSCI-SWITZ
JI Front. Neurosci.
PY 2013
VL 7
AR 148
DI 10.3389/fnins.2013.00148
PG 18
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA AW9HF
UT WOS:000346567300147
PM 24009547
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Drapeau, V
   Therrien, F
   Richard, D
   Tremblay, A
AF Drapeau, V
   Therrien, F
   Richard, D
   Tremblay, A
TI Is visceral obesity a physiological adaptation to stress?
SO PANMINERVA MEDICA
LA English
DT Article
DE obesity; stress; abdomen; hydrocortisone; pituitary adrenal system;
   hypothalamo, hypophyseal system
ID BODY-FAT DISTRIBUTION; PITUITARY-ADRENAL AXIS; HYPOTHALAMIC
   PARAVENTRICULAR NUCLEUS; CORTICOTROPIN-RELEASING HORMONE; ADIPOSE-TISSUE
   DISTRIBUTION; CORTISOL SECRETION; ZUCKER RATS; METABOLIC SYNDROME;
   ABDOMINAL OBESITY; CUSHINGS-SYNDROME
AB Visceral obesity represents an important risk factor associated with hypertension, diabetes and cardiovascular diseases. Since this condition is associated with a disruption of the functioning of the HPA axis, stress-induced HPA axis activation has been identified to play an important role in this preferential body fat accumulation. HPA axis activation increases cortisol (corticosterone) production which has been shown to exert hyperphagic and antithermogenic effects. Since abdominal adipose tissue has more cells per mass units, higher blood flow and more glucocorticoid receptors, glucocorticoids; affect abdominal fat to a greater extent than subcutaneous adipose tissue. Cushing's syndrome in humans is the best evidence showing a link between hypercortisolemia and accumulation of central fat. The Hervey's hypothesis which suggests that fat cells take up and catabolize glucocorticoids is one of the possible regulatory effect that supports the adaptive role of visceral fat in response to stress. This is also supported by other evidence showing that abdominal obesity is associated with an increased cortisol clearance. Hormonal and enzymatic changes have been implicated in this preferential body fat accumulation in response to stress. Specific genetic background may also accentuate this visceral fat accumulation in some individuals exposed to stress. Alternatively, obesity could also be a source of stress promoting the visceral fat accumulation since visceral fat is able to release cytokines which stimulate the HPA axis. Even if the available literature does not permit to establish clearly which comes first, it suggests that visceral obesity could represent a non optimal physiological adaptation to stress. In this context, visceral obesity treatment should focus on stress management and weight loss strategies in order to stop this vicious circle.
C1 Univ Laval, Div Kinesiol, St Foy, PQ G1K 7P4, Canada.
   Univ Quebec, Dept Anat & Physiol, St Foy, PQ G1V 2M3, Canada.
C3 Laval University; University of Quebec
RP Tremblay, A (corresponding author), Univ Laval, Div Kinesiol, St Foy, PQ G1K 7P4, Canada.
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NR 58
TC 79
Z9 99
U1 0
U2 5
PU EDIZIONI MINERVA MEDICA
PI TURIN
PA CORSO BRAMANTE 83-85 INT JOURNALS DEPT., 10126 TURIN, ITALY
SN 0031-0808
J9 PANMINERVA MED
JI Panminerva Medica
PD SEP
PY 2003
VL 45
IS 3
BP 189
EP 195
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 759ZM
UT WOS:000187784800004
PM 14618117
DA 2025-06-11
ER

PT J
AU Cutrupi, F
   De Luca, A
   Di Zazzo, A
   Micera, A
   Coassin, M
   Bonini, S
AF Cutrupi, Francesco
   De Luca, Andrea
   Di Zazzo, Antonio
   Micera, Alessandra
   Coassin, Marco
   Bonini, Stefano
TI Real Life Impact of Dye Eye Disease
SO SEMINARS IN OPHTHALMOLOGY
LA English
DT Review
DE Dry Eye Disease; quality of life; driving; work performance; depression;
   suicidal ideations; sleep; exercise; diet; review
ID QUALITY-OF-LIFE; WORK PRODUCTIVITY LOSS; ALL-CAUSE MORTALITY; DRY EYE;
   METABOLIC SYNDROME; SLEEP QUALITY; RISK-FACTORS; FATTY-ACIDS; VITAMIN-A;
   OFFICE ENVIRONMENT
AB Dry Eye Disease (DED) is an increasingly common condition that affects between 5% and 50% of the global population. Even though DED is most frequently diagnosed in older people, it has also been diagnosed in young adults and adolescents more frequently in recent years (employees, gamers). People can experience different types of symptoms and find it challenging to read, watch TV, cook, climb stairs, and meet friends. Mild and severe dry eye can reduce quality of life similarly to mild psoriasis and moderate-to-severe angina. Furthermore, DED patients experience serious difficulties driving vehicles, especially at night, and show a decrease in work productivity, which, when combined with the relevant indirect cost that this condition produces, poses a serious challenge in our days. In addition, DED patients are more likely to develop depression and suicidal ideations and experience frequent sleep disorders. Finally, it is discussed how lifestyle changes, such as increased physical activity, blinking exercises, and a proper diet, have positive implications for the management of this condition. Our aim is to draw attention to the negative effects of dry eye in real life, which are unique to each patient, especially as they relate to the non-visual symptoms experienced by DED patients.
C1 [Cutrupi, Francesco; De Luca, Andrea; Coassin, Marco; Bonini, Stefano] Univ Campus Biomed, Ophthalmol Complex Operat Unit, Rome, Italy.
   [Di Zazzo, Antonio; Micera, Alessandra] IRCCS Bietti Fdn, Res Labs Ophthalmol, Rome, Italy.
   [Di Zazzo, Antonio] Univ Campus Biomed, Ophthalmol Complex Operat Unit, I-00128 Rome, Italy.
C3 University Campus Bio-Medico - Rome Italy; IRCCS - Fondazione "G.B.
   Bietti" per lo Studio e la Ricerca in Oftalmologia; University Campus
   Bio-Medico - Rome Italy
RP Di Zazzo, A (corresponding author), Univ Campus Biomed, Ophthalmol Complex Operat Unit, I-00128 Rome, Italy.
EM a.dizazzo@policlinicocampus.it
RI Micera, Alessandra/J-3373-2013; Coassin, Marco/HTR-3471-2023; Bonini,
   Stefano/A-2250-2012
OI Bonini, Stefano/0000-0002-7787-2144
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NR 158
TC 12
Z9 12
U1 3
U2 8
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 0882-0538
EI 1744-5205
J9 SEMIN OPHTHALMOL
JI Semin. Ophthalmol.
PD NOV 17
PY 2023
VL 38
IS 8
BP 690
EP 702
DI 10.1080/08820538.2023.2204931
EA APR 2023
PG 13
WC Ophthalmology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Ophthalmology
GA T2QN2
UT WOS:000974626700001
PM 37095685
DA 2025-06-11
ER

PT J
AU Francis, J
   Rajasegaran, R
   Prabhakaran, S
AF Francis, Jezreel
   Rajasegaran, Rajalakshmi
   Prabhakaran, Soundararajan
TI Appetitive Traits and its Association with Body Composition,
   Anthropometric Indices and Appearance Anxiety in Adults: A
   Cross-sectional Study
SO JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH
LA English
DT Article
DE Appetite; Body shape; Food approach; Food avoidance; Obesity
ID DISSATISFACTION; PREVALENCE; VALIDATION
AB Introduction: Obesity, a major health hazard in both developed and developing countries, is greatly influenced by an individual's eating behaviour or appetitive trait. While eating disorders are known to be associated with abnormal body composition and cardio-metabolic risks, on par with metabolic syndrome, knowledge regarding the relationship between appetitive traits and body composition and anthropometric indices is very limited.
   Aim: To assess the appetitive traits of young and middle-aged individuals and correlate them with their body composition, anthropometric indices, and appearance anxiety.
   Materials and Methods: Sixty-eight healthy volunteers aged 19-45 years were included in this cross-sectional study. The appetitive traits, appearance anxiety, and perceived body shape of the study participants were assessed using the Adult Eating Behaviour Questionnaire (AEBQ), Appearance Anxiety Inventory (AAI), and Contour Drawing Rating Scale (CDRS). Body composition was assessed using Bioelectrical Impedance Analysis (BIA). The correlation between appetitive trait scores and the study parameters was assessed using the Pearson or Spearman correlation coefficient test. Comparison of appetitive traits between males and females was done using the Independent t-test or Mann-Whitney U test. A p-value <0.05 was considered statistically significant.
   Results: There were 43 males and 25 females. Significant negative correlations were observed between food avoidance scores and body composition parameters such as BMI, waist-to-height ratio, lean mass, dry lean weight, body cell mass, basal metabolic rate, and Fat-Free Mass Index (FFMI). While food approach behaviour was similar between females and males, the overall food avoidance behaviour trait (53.4 +/- 11.2 vs. 47.26 +/- 9.09, p=0.016) and satiety responsiveness (12.28 +/- 3.2 vs. 10.51 +/- 2.93, p=0.024) were significantly more pronounced in females than in males. Moreover, the food avoidance behaviour of females revealed significant negative correlations with BMI, fat mass, lean mass, body cell mass, basal metabolic rate, Body Fat Mass Index (BFMI), free-fat mass index, and CDRS scores.
   Conclusion: The food avoidance trait is associated with abnormal changes in specific body composition parameters in adults. Satiety responsiveness and body dis-satisfaction related to being overweight are more common among young females and are associated with abnormal changes in their body composition.
C1 [Francis, Jezreel; Rajasegaran, Rajalakshmi; Prabhakaran, Soundararajan] Jawaharlal Inst Postgrad Med Educ & Res JIPMER, Dept Physiol, Pondicherry 605006, India.
C3 Jawaharlal Institute of Postgraduate Medical Education & Research
RP Rajasegaran, R (corresponding author), Jawaharlal Inst Postgrad Med Educ & Res JIPMER, Dept Physiol, Pondicherry 605006, India.
EM rajalakshmimd@yahoo.com
RI Rajasegaran, Rajalakshmi/GOV-5837-2022
CR [Anonymous], 2020, Professor David Veale
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NR 35
TC 1
Z9 1
U1 4
U2 6
PU PREMCHAND SHANTIDEVI RESEARCH FOUNDATION
PI DELHI
PA 71 JAIN COLONY, VEER NAGAR, DELHI, 110 007, INDIA
SN 2249-782X
EI 0973-709X
J9 J CLIN DIAGN RES
JI J. Clin. Diagn. Res.
PD JUN
PY 2024
VL 18
IS 6
BP CC13
EP CC17
DI 10.7860/JCDR/2024/69386.19483
PG 5
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA D3B1K
UT WOS:001294962000005
OA gold
DA 2025-06-11
ER

PT J
AU Gisondi, P
   Sala, F
   Alessandrini, F
   Avesani, V
   Zoccatelli, G
   Beltramello, A
   Moretto, G
   Gambina, G
   Girolomoni, G
AF Gisondi, Paolo
   Sala, Francesca
   Alessandrini, Franco
   Avesani, Virginia
   Zoccatelli, Giada
   Beltramello, Alberto
   Moretto, Giuseppe
   Gambina, Giuseppe
   Girolomoni, Giampiero
TI Mild Cognitive Impairment in Patients with Moderate to Severe Chronic
   Plaque Psoriasis
SO DERMATOLOGY
LA English
DT Article
DE Psoriasis; Mild cognitive impairment; Brain imaging; Diffusion tensor
   imaging; Dementia screening
ID METABOLIC SYNDROME; CLASSIFICATION CRITERIA; PERISPINAL ETANERCEPT;
   ALZHEIMERS-DISEASE; NORMATIVE DATA; DEMENTIA; RISK; DEPRESSION; BATTERY
AB Background: Psoriasis is frequently associated with cardio-metabolic comorbidities and depression that are risk factors for cognitive impairment. Objective: To investigate cognitive performance in psoriatic patients. Method: Cognitive performances were assessed by neuropsychological tests in 41 patients with psoriasis and 37 controls. Diagnostic criteria for mild cognitive impairment (MCI) were (1) subjective complaint of a memory deficit, confirmed by a relative or caregiver, (2) pathological performance on neuropsychological tests investigating cognitive domains, (3) normal performance of daily living activities and (4) no dementia. Neuroimaging was studied by high-field magnetic resonance imaging and cortical thickness analysis. Results:MCI was found in 18 out of 41(44%) patients with psoriasis compared to 4 out of 37 (11%) controls (p = 0.002). In particular, patients with psoriasis had lower scores in the delayed recall of the Rey Auditory Verbal Learning Test (p = 0.04), Backwards Digit Span Test (p = 0.002), Weigl's Sorting Test (p = 0.01) and Trail Making Test B (p = 0.008). In the 7 patients submitted to cortical thickness analysis, a reduction in brain thickness in parahippocampal, superior temporal and frontal gyri of the left hemisphere was observed. Conclusions: Patients with psoriasis may have a precocious impairment of long-term verbal memory, executive functions and attention. (C) 2014 S. Karger AG, Basel
C1 [Gisondi, Paolo; Girolomoni, Giampiero] Univ Verona, Dept Med, Sect Dermatol & Venereol, IT-37126 Verona, Italy.
   [Sala, Francesca; Avesani, Virginia; Moretto, Giuseppe] Azienda Osped Univ Integrata, Ctr Alzheimer & Cognit Dis, Neurol Unit, Verona, Italy.
   [Alessandrini, Franco; Zoccatelli, Giada; Beltramello, Alberto; Gambina, Giuseppe] Azienda Osped Univ Integrata, Neuroradiol Serv, Verona, Italy.
C3 University of Verona; University of Verona; Azienda Ospedaliera
   Universitaria Integrata Verona; University of Verona; Azienda
   Ospedaliera Universitaria Integrata Verona
RP Gisondi, P (corresponding author), Univ Verona, Dept Med, Sect Dermatol & Venereol, Piazzale Stefani 1, IT-37126 Verona, Italy.
EM paolo.gisondi@univr.it
RI GIROLOMONI, Giampiero/AAC-3405-2022; Della Sala,
   Francesca/LTE-8808-2024; Gisondi, Paolo/AGI-4840-2022
OI GISONDI, Paolo/0000-0002-1777-9001
FU Ministero della Salute; Ministero dell'Istruzione, Universita e Ricerca
   Scientifica (Programmi di Ricerca Scientifica di Rilevante Interesse
   Nazionale); Association for Dermatological Research
FX This work was supported by the Ministero della Salute and the Ministero
   dell'Istruzione, Universita e Ricerca Scientifica (Programmi di Ricerca
   Scientifica di Rilevante Interesse Nazionale), and by the Association
   for Dermatological Research.
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NR 45
TC 52
Z9 55
U1 1
U2 16
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1018-8665
EI 1421-9832
J9 DERMATOLOGY
JI Dermatology
PY 2014
VL 228
IS 1
BP 78
EP 85
DI 10.1159/000357220
PG 8
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA AA5RT
UT WOS:000331158000017
PM 24434720
DA 2025-06-11
ER

PT J
AU Mielke, JG
   Taghibiglou, C
   Liu, LD
   Zhang, Y
   Jia, ZP
   Adeli, K
   Wang, YT
AF Mielke, JG
   Taghibiglou, C
   Liu, LD
   Zhang, Y
   Jia, ZP
   Adeli, K
   Wang, YT
TI A biochemical and functional characterization of diet-induced brain
   insulin resistance
SO JOURNAL OF NEUROCHEMISTRY
LA English
DT Article
DE diabetes; hippocampus; insulin resistance; long-term depression;
   long-term potentiation; synaptic plasticity
ID LONG-TERM POTENTIATION; PROTEIN-TYROSINE PHOSPHATASE-1B; HIPPOCAMPAL
   SYNAPTIC PLASTICITY; TRIGLYCERIDE TRANSFER PROTEIN;
   STREPTOZOTOCIN-DIABETIC RATS; AMPA RECEPTOR ENDOCYTOSIS; KINASE-B;
   PHOSPHATIDYLINOSITOL 3-KINASE; GLUTAMATE RECEPTORS; GLUCOSE-TRANSPORT
AB While considerable research has examined diminished insulin responses within peripheral tissues, comparatively little has been done to examine the effects of this metabolic disruption upon the CNS. The present study employed biochemical and electrophysiological assays of acutely prepared brain slices to determine whether neural insulin resistance is a component of the metabolic syndrome observed within the fructose-fed (FF) hamster. The tyrosine phosphorylation levels of the insulin receptor (IR) and insulin receptor substrate 1 (IRS-1) in response to insulin were significantly reduced within FF hamsters. Also, insulin-mediated phosphorylation of both residues necessary for activation of the serine-threonine kinase Akt/PKB, a key effector of insulin signaling, was markedly decreased. Elevated levels of the protein tyrosine phosphatase 1B, which dephosphorylates the IR and IRS-1, were also observed within the cerebral cortex and hippocampus of FF hamsters. Examination of whether a nutritionally induced compromise of neural insulin signaling altered synaptic function revealed a significant attenuation of insulin-induced long-term depression, but no effect upon either paired-pulse facilitation or electrically induced long-term potentiation. Collectively, our results demonstrate, for the first time, that nutritionally induced insulin resistance significantly affects the neural insulin signaling pathway, and suggest that brain insulin resistance may contribute to cognitive impairment.
C1 Univ British Columbia, Brain Res Ctr, Vancouver, BC V6T 2B5, Canada.
   Hosp Sick Children, Brain & Behav Program, Toronto, ON M5G 1X8, Canada.
   Hosp Sick Children, Dept Pediat Lab Med, Toronto, ON M5G 1X8, Canada.
   Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON, Canada.
C3 University of British Columbia; University of Toronto; Hospital for Sick
   Children (SickKids); University of Toronto; Hospital for Sick Children
   (SickKids); University of Toronto
RP Univ British Columbia, Brain Res Ctr, 2211 Westbrook Mall, Vancouver, BC V6T 2B5, Canada.
EM ytwang@interchange.ubc.ca
RI Taghibiglou, Changiz/H-4590-2019; Wang, Yu/J-8255-2015; Jia,
   zhengping/AAZ-4190-2021
OI Liu, Lidong/0000-0002-7026-690X; Adeli, Khosrow/0000-0002-5839-5709
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TC 162
Z9 175
U1 0
U2 11
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-3042
EI 1471-4159
J9 J NEUROCHEM
JI J. Neurochem.
PD JUN
PY 2005
VL 93
IS 6
BP 1568
EP 1578
DI 10.1111/j.1471-4159.2005.03155.x
PG 11
WC Biochemistry & Molecular Biology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Neurosciences & Neurology
GA 930OM
UT WOS:000229425800022
PM 15935073
DA 2025-06-11
ER

PT J
AU Vieta, E
AF Vieta, E
TI Olanzapine in bipolar disorder
SO EXPERT OPINION ON PHARMACOTHERAPY
LA English
DT Review
DE bipolar disorder; clinical trials; depression; mania; olanzapine;
   prophylaxis
ID DOUBLE-BLIND; ACUTE MANIA; I-DISORDER; ATYPICAL ANTIPSYCHOTICS;
   COMPARATIVE EFFICACY; DIVALPROEX SODIUM; PLACEBO; THERAPY; SAFETY;
   TOLERABILITY
AB Olanzapine is currently marketed not only for the treatment of schizophrenia, but also for the treatment of acute mania and the prevention of relapse in patients successfully treated with this drug for a manic episode. A large body of good clinical trials supports these indications. In the mania trials, olanzapine was more efficacious than placebo, equal or more efficacious than valproate and more efficacious than lithium or valproate monotherapy when used in combination with either drug. A trial that compared olanzapine with haloperidol failed to show superiority of the atypical versus the conventional. Olanzapine showed a modest but statistically significant effect in the treatment of bipolar depression; this modest effect was substantially enhanced in combination with fluoxetine. The long-term trials showed that olanzapine was better than placebo in the prevention of manic and depressive relapse and not inferior to lithium or valproate. The combination of olanzapine with lithium or valproate was also more efficacious than lithium or valproate alone in the prevention of manic relapse in patients partially non-responding to monotherapy with lithium or valproate. All these trials suggest that olanzapine may be a valuable drug in the short- and long-term treatment of bipolar I disorder. However, there are some concerns about the safety and tolerability of olanzapine in this population, as far as weight gain and metabolic syndrome are concerned, which may be addressed in future pharmacovigilance studies.
C1 Univ Barcelona, Hosp Clin, Bipolar Disorders Program, Barcelona 08036, Spain.
C3 University of Barcelona; Hospital Clinic de Barcelona
RP Univ Barcelona, Hosp Clin, Bipolar Disorders Program, Villarroel 170,Rossello 140, Barcelona 08036, Spain.
EM evieta@clinic.ub.es
RI Vieta, Eduard/Y-2919-2019; Vieta, Eduard/I-6330-2013
OI Vieta, Eduard/0000-0002-0548-0053
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   VIETA E, IN PRESS PSYCHOTHER
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NR 44
TC 13
Z9 13
U1 0
U2 6
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1465-6566
EI 1744-7666
J9 EXPERT OPIN PHARMACO
JI Expert Opin. Pharmacother.
PD JUL
PY 2004
VL 5
IS 7
BP 1613
EP 1619
DI 10.1517/14656566.5.7.1613
PG 7
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 839XO
UT WOS:000222818500016
PM 15212611
DA 2025-06-11
ER

PT J
AU Park, JJ
   Park, SJ
   Choi, DJ
AF Park, Jin Joo
   Park, Sung-Ji
   Choi, Dong-Ju
TI Microvascular angina: angina that predominantly affects women
SO KOREAN JOURNAL OF INTERNAL MEDICINE
LA English
DT Review
ID CORONARY-ARTERY-DISEASE; CARDIAC SYNDROME-X; FRACTIONAL FLOW RESERVE;
   CHEST-PAIN; MYOCARDIAL-ISCHEMIA; CLINICAL PRESENTATION;
   MAGNETIC-RESONANCE; DIABETES-MELLITUS; STABLE ANGINA; NITRIC-OXIDE
AB In women receiving evaluation for suspected ischemic symptoms, a "normal" diagnosis is five times more common than it is in men. These women are often labeled as having cardiac syndrome X, also known as microvascular angina (MVA). MVA is defined as angina pectoris caused by abnormalities of the small coronary arteries, and is characterized by effort chest pain and evidence of myocardial ischemia with a non-invasive stress test, although the coronary arteries can appear normal or near normal by angiography. MVA patients are often neglected due to the assumption of a good prognosis. However, MVA has important prognostic implications and a proper diagnosis is necessary in order to relieve the patients' symptoms and improve clinical outcomes. The coronary microvasculature cannot be directly imaged using coronary angiography, due to the small diameter of the vessels; therefore, the coronary microvascular must be assessed functionally. Treatment of MVA initially includes standard anti-ischemic drugs (beta-blockers, calcium antagonists, and nitrates), although control of symptoms is often insufficient. In this review, we discuss the pathophysiology, diagnosis, and treatment of MVA.
C1 [Park, Jin Joo; Choi, Dong-Ju] Seoul Natl Univ, Bundang Hosp, Cardiovasc Ctr, Dept Internal Med, Songnam, South Korea.
   [Park, Sung-Ji] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr,Div Cardiol, Cardiovasc Imaging Ctr,Heart Vasc Stoke Inst,Dept, Seoul 135710, South Korea.
   [Choi, Dong-Ju] Seoul Natl Univ, Coll Med, Seoul, South Korea.
C3 Seoul National University (SNU); Sungkyunkwan University (SKKU); Samsung
   Medical Center; Seoul National University (SNU)
RP Park, SJ (corresponding author), Sungkyunkwan Univ, Sch Med, Samsung Med Ctr,Div Cardiol, Cardiovasc Imaging Ctr,Heart Vasc Stoke Inst,Dept, 81 Irwon Ro, Seoul 135710, South Korea.
EM sungji.park@samsung.com
RI Choi, Dong-Ju/J-5686-2012
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NR 53
TC 7
Z9 9
U1 3
U2 10
PU KOREAN ASSOC INTERNAL MEDICINE
PI SEOUL
PA 101-2501 LOTTE CASTLE PRESIDENT, 109 MAPO-DAERO, MAPO-GU, SEOUL,
   121-916, SOUTH KOREA
SN 1226-3303
EI 2005-6648
J9 KOREAN J INTERN MED
JI Korean J. Intern. Med.
PD MAR
PY 2015
VL 30
IS 2
BP 140
EP 147
DI 10.3904/kjim.2015.30.2.140
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA CD9LL
UT WOS:000351419700002
PM 25750553
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Alshehri, T
   Boone, S
   de Mutsert, R
   Penninx, B
   Rosendaal, F
   le Cessie, S
   Milaneschi, Y
   Mook-Kanamori, D
AF Alshehri, Tahani
   Boone, Sebastiaan
   de Mutsert, Renee
   Penninx, Brenda
   Rosendaal, Frits
   le Cessie, Saskia
   Milaneschi, Yuri
   Mook-Kanamori, Dennis
TI The association between overall and abdominal adiposity and depressive
   mood: A cross-sectional analysis in 6459 participants
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE Abdominal fat; Body fat distribution; Body mass index; Depression;
   Depressive disorder; Obesity
ID WAIST CIRCUMFERENCE; METABOLIC SYNDROME; ATYPICAL FEATURES; MAJOR
   DEPRESSION; LINKING OBESITY; VISCERAL FAT; LEPTIN; EPIDEMIOLOGY;
   SYMPTOMS; DISORDER
AB Objective: We aimed to evaluate the association between measures of adiposity with depressive mood and specific depressive symptoms.
   Methods: This study was performed in the Netherlands Epidemiology of Obesity (NEO) study, a population-based study that consists of 6671 middle-aged individuals. We examined the association between measures of overall adiposity (BMI and total body fat), and abdominal adiposity (waist circumference and visceral adipose tissue), with depressive mood severity subgroups and 30 depressive symptoms. Multinomial logistic regression was performed adjusting for potential confounding.
   Results: Measures of adiposity were associated with depressive mood in a graded fashion. Total body fat showed the strongest association with mild (Odds Ratio (OR): 1.59 per standard deviation, 95% Confidence Interval (95% CI): 1.41-1.80) and moderate to very severe (OR: 1.97, 95% CI: 1.59-2.44) depressive mood. Regarding individual symptoms of depressive mood, total body fat was associated with most depressive symptoms (strongest associations for hyperphagia and fatigability).
   Conclusions: In the general population, overall and abdominal adiposity measures were associated with depressive mood. This association encompasses most of the depressive symptoms and appeared to be the strongest with specific "atypical" neurovegetative symptoms, which may be an indication of an alteration in the energy homeostasis.
C1 [Alshehri, Tahani; Boone, Sebastiaan; de Mutsert, Renee; Rosendaal, Frits; le Cessie, Saskia; Mook-Kanamori, Dennis] Leiden Univ, Med Ctr, Dept Clin Epidemiol, Leiden, Netherlands.
   [Penninx, Brenda; Milaneschi, Yuri] VU, Amsterdam UMC, Amsterdam Neurosci, Dept Psychiat,Amsterdam Publ Hlth Res Inst, Amsterdam, Netherlands.
   [le Cessie, Saskia] Leiden Univ, Med Ctr, Dept Med Stat, Leiden, Netherlands.
   [Milaneschi, Yuri] GGZ InGeest, Res & Innovat, Amsterdam, Netherlands.
   [Mook-Kanamori, Dennis] Leiden Univ, Med Ctr, Dept Publ Hlth & Primary Care, Leiden, Netherlands.
C3 Leiden University; Leiden University Medical Center (LUMC); Leiden
   University - Excl LUMC; University of Amsterdam; Vrije Universiteit
   Amsterdam; Leiden University - Excl LUMC; Leiden University; Leiden
   University Medical Center (LUMC); Leiden University - Excl LUMC; Leiden
   University; Leiden University Medical Center (LUMC)
RP Alshehri, T (corresponding author), LUMC, Albinusdreef 2,Postzone C7-P,Postbus 9600, NL-2300 RC Leiden, Netherlands.
EM t.m.alshehri@lumc.nl
RI le+Cessie, Saskia/HGC-8966-2022; Rosendaal, Frits/Q-3842-2017; Alshehri,
   Tahani/IUP-1119-2023; Boone, Sebastiaan/A-1898-2019; Penninx, Brenda
   WJH/S-7627-2017
OI Milaneschi, Yuri/0000-0002-3697-6617; Boone,
   Sebastiaan/0000-0002-2411-0699; Alshehri, Tahani/0000-0001-5500-4779;
   Penninx, Brenda WJH/0000-0001-7779-9672
FU Leiden University Medical Centre; Leiden University
FX The NEO study is supported by the participating Departments, the
   Division and the Board of Directors of the Leiden University Medical
   Centre, and by the Leiden University, Research Profile Area 'Vascular
   and Regenerative Medicine'.
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NR 45
TC 38
Z9 40
U1 1
U2 4
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD DEC
PY 2019
VL 110
AR 104429
DI 10.1016/j.psyneuen.2019.104429
PG 8
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA JS6AW
UT WOS:000500388600014
PM 31526909
OA hybrid
DA 2025-06-11
ER

PT J
AU Zhou, SJ
   Zhang, LG
   Chen, HM
   Li, JY
   Li, R
   Zhang, XM
   Wang, N
   Soares, JC
   Cassidy, RM
   Zheng, YJ
   Ning, YP
   Wang, SL
   Chen, JX
   Zhang, XY
AF Zhou, Shuang-Jiang
   Zhang, Li-Gang
   Chen, Hong-Mei
   Li, Ju-Yan
   Li, Ran
   Zhang, Xi-Mei
   Wang, Ning
   Soares, Jair C.
   Cassidy, Ryan M.
   Zheng, Yingjun
   Ning, Yuping
   Wang, Shao-Li
   Chen, Jing-Xu
   Zhang, Xiang-Yang
TI Prevalence and clinical-demographic correlates of hyperhomocysteinemia
   in inpatients with bipolar disorder in a Han Chinese population
SO PSYCHIATRY RESEARCH
LA English
DT Article
DE Homocysteine; Bipolar disorder; Prevalence; Body mass index; Valproate;
   Lithium
ID ELEVATED HOMOCYSTEINE LEVELS; PLASMA HOMOCYSTEINE; SERUM HOMOCYSTEINE;
   METABOLIC SYNDROME; CONTROLLED-TRIAL; DOUBLE-BLIND; ASSOCIATION;
   DEPRESSION; SCHIZOPHRENIA; METHIONINE
AB Recent studies have reported that hyperhomocystinemia (HHcy) is highly prevalent in patients with bipolar disorder (BD), placing them at greater risk of cardiovascular disease and possibly serving as a disease biomarker. However, the correlation of HHcy with demographic or clinical parameters is not well known. In this study, we examined the prevalence of HHcy and its association with these parameters in a sample of Chinese BD patients. Fasting plasma homocysteine (Hcy) levels were determined in 198 BD inpatients and 84 healthy controls. HHcy was defined when Hcy concentration exceeded 15.0 mu mol/L. Affective symptomatology was assessed by the Young Mania Rating Scale, Hamilton Depression Rating Scale and the Clinical Global Impressions severity scale. Compared to healthy controls, BD patients had a significantly higher prevalence (34.85% vs. 19.05%) of HHcy and a higher absolute level of homocysteine. Logistic regression analysis demonstrated that BD patients with HHcy were more likely to be male, have elevated BMI, more frequent treatment on lithium but less on valproate. These results suggest that Chinese inpatients with bipolar disorder have a higher rate of HHcy than the general population, and those at greatest risk are male, have an elevated BMI, and take more lithium but less valproate therapy.
C1 [Zhou, Shuang-Jiang; Zhang, Li-Gang; Chen, Hong-Mei; Li, Ju-Yan; Li, Ran; Zhang, Xi-Mei; Wang, Ning; Wang, Shao-Li; Chen, Jing-Xu] Peking Univ, Beijing Hui Long Guan Hosp, Beijing 100096, Peoples R China.
   [Soares, Jair C.; Cassidy, Ryan M.; Zhang, Xiang-Yang] Univ Texas Hlth Sci Ctr Houston, Dept Psychiat & Behav Sci, Houston, TX 77030 USA.
   [Zheng, Yingjun; Ning, Yuping; Zhang, Xiang-Yang] Guangzhou Med Univ, Guangzhou Huiai Hosp, Affiliated Brain Hosp, Guangzhou, Guangdong, Peoples R China.
C3 Peking University; Baylor College of Medicine; Baylor College Medical
   Hospital; University of Texas System; University of Texas Health Science
   Center Houston; Guangzhou Medical University
RP Wang, SL; Chen, JX (corresponding author), Beijing Hui Long Guan Hosp, Beijing 100096, Peoples R China.; Zhang, XY (corresponding author), 1941 East Rd, Houston, TX 77054 USA.
EM wangshl82@sina.com; chenjx1110@163.com; Xiang.y.zhang@uth.tmc.edu
RI Chen, Hongmei/L-1798-2015; Chen, Jingxu/KMY-3853-2024; han,
   Yuyan/JPL-8939-2023; juyan, li/MZR-7675-2025; Zhang,
   Xiangyang/ABC-7380-2022; Li, Ran/HNQ-5019-2023; Zhou,
   Shuangjiang/O-2390-2014
OI Zhang, Xiangyang/0000-0003-3326-382X; Zhou,
   Shuangjiang/0000-0001-9913-8074; Soares, Jair C./0000-0002-5466-5628;
   Cassidy, Ryan Michael/0000-0003-4100-0413
FU NCATS NIH HHS [TL1 TR000369] Funding Source: Medline
CR Almeida OP, 2008, ARCH GEN PSYCHIAT, V65, P1286, DOI 10.1001/archpsyc.65.11.1286
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NR 47
TC 11
Z9 11
U1 0
U2 11
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0165-1781
J9 PSYCHIAT RES
JI Psychiatry Res.
PD JAN
PY 2018
VL 259
BP 364
EP 369
DI 10.1016/j.psychres.2017.08.063
PG 6
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA FU1ZT
UT WOS:000423648700057
PM 29120844
DA 2025-06-11
ER

PT J
AU Zhang, Q
   Li, XM
   Qiao, S
   Liu, SF
   Shen, ZY
   Zhou, YJ
AF Zhang, Quan
   Li, Xiaoming
   Qiao, Shan
   Liu, Shuaifeng
   Shen, Zhiyong
   Zhou, Yuejiao
TI Greater Pain Severity is Associated with Higher Glucocorticoid Levels in
   Hair Among a Cohort of People Living with HIV
SO JOURNAL OF PAIN RESEARCH
LA English
DT Article
DE pain; hair cortisol; hair cortisone; HIV
ID QUALITY-OF-LIFE; INTRAINDIVIDUAL STABILITY; CORTISOL CONCENTRATIONS;
   METABOLIC SYNDROME; MEDICAL OUTCOMES; STRESS; DEPRESSION; SALIVARY;
   HEALTH; BIOMARKER
AB Background: Pain is a common occurrence and persistent symptom, which has an adverse impact on individual well-being and quality of life among people living with HIV (PLHIV). Alteration in the activity of the Hypothalamic-Pituitary-Adrenal (HPA) axis resulting in abnormal glucocorticoid levels had been proposed to play important roles in those associations.
   Purpose: This study aimed to investigate whether pain severity was associated with hair glucocorticoid levels, a novel method of measuring long-term glucocorticoid exposure, among a large cohort of Chinese PLHIV.
   Methods: A measure of pain severity and hair samples were collected from 431 adults PLHIV in Guangxi, China. Glucocorticoid (cortisol and cortisone) in hair were quantified by liquid chromatography-tandem mass spectrometry. The general linear model was used to test the associations of pain severity with hair glucocorticoid levels after adjusting for potential confounding factors.
   Results: Of the 431 PLHIV, 273 reported none pain, 87 reported mild pain, and 71 reported moderate-severe pain. Hair cortisone, but not hair cortisol, was found to differ significantly among the three pain severity groups (F=3.90, p=0.021). PLHIV reported moderate-severe pain had higher hair cortisone than those reported mild (p=0.070) or none pain (p=0.014), with no differences between the latter two pain severity groups.
   Conclusion: Greater pain severity is associated with higher hair cortisone levels among Chinese PLHIV. In order to reduce the long-term glucocorticoid levels, interventions managing pain should be considered for PLHIV with moderate-severe pain.
C1 [Zhang, Quan; Li, Xiaoming; Qiao, Shan] Univ South Carolina, South Carolina SmartState Ctr Healthcare Qual CHQ, Arnold Sch Publ Hlth, Discovery 1,Suite 408,915 Greene St, Columbia, SC 29028 USA.
   [Zhang, Quan] Hohai Univ, Sch Publ Adm, Inst Pedag & Appl Psychol, Nanjing, Jiangsu, Peoples R China.
   [Liu, Shuaifeng; Shen, Zhiyong; Zhou, Yuejiao] Guangxi Zhuang Autonomous Reg Ctr Dis Control & P, 18 Jinzhou Rd, Nanning 530028, Guangxi, Peoples R China.
C3 University of South Carolina System; University of South Carolina
   Columbia; Hohai University
RP Zhang, Q (corresponding author), Univ South Carolina, South Carolina SmartState Ctr Healthcare Qual CHQ, Arnold Sch Publ Hlth, Discovery 1,Suite 408,915 Greene St, Columbia, SC 29028 USA.; Zhou, YJ (corresponding author), Guangxi Zhuang Autonomous Reg Ctr Dis Control & P, 18 Jinzhou Rd, Nanning 530028, Guangxi, Peoples R China.
EM quanz@mailbox.sc.edu; gxcdcj2013@163.com
RI Li, Huihuang/GNM-7727-2022; Zhang, Quan/ABF-9541-2020
OI Zhang, Quan/0000-0001-6028-6977
FU National Institutes of Health (NIH) Research Grant [R01HD074221,
   R21AI122919]
FX This study was supported by the National Institutes of Health (NIH)
   Research Grant [Grant numbers R01HD074221, R21AI122919].
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NR 60
TC 2
Z9 2
U1 0
U2 6
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-7090
J9 J PAIN RES
JI J. Pain Res.
PY 2021
VL 14
BP 645
EP 652
DI 10.2147/JPR.S301651
PG 8
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology
GA QX2KZ
UT WOS:000629178100001
PM 33727858
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Müller, MJ
   Olschinski, C
   Kundermann, B
   Cabanel, N
AF Mueller, Matthias J.
   Olschinski, Christiane
   Kundermann, Bernd
   Cabanel, Nicole
TI Sleep Duration of Inpatients With a Depressive Disorder: Associations
   With Age, Subjective Sleep Quality, and Cognitive Complaints
SO ARCHIVES OF PSYCHIATRIC NURSING
LA English
DT Article
ID JOINT CONSENSUS STATEMENT; DAYTIME SLEEPINESS; EXCESSIVE SLEEPINESS;
   RECOMMENDED AMOUNT; METABOLIC SYNDROME; AMERICAN ACADEMY; HEALTHY ADULT;
   STILL NEED; INSOMNIA; SYMPTOMS
AB Sleep complaints and sleep disturbances are common in depression; however, the association of sleep duration and subjective sleep quality has been rarely investigated. Thus, subjective sleep quality and sleep duration were analyzed in depressed inpatients. Questionnaire data comprising clinical and sleep-related questions were sampled over a one-year period from adult inpatients with depressive syndromes. Sleep duration and items related to sleep quality were analyzed by means of group comparisons (sleep duration categories) and correlation analyses. Data of 154 patients (age 58.2 +/- 17.0 years, 63.6% women) were analyzed. Mean sleep duration was 7.2 +/- 2.1 h (16.9% of patients were below and 7.1% above age-specific recommendations), 25-40% of patients reported almost always daytime sleepiness, non-restorative sleep, attention deficits, or memory complaints with significant correlations between all variables (P < 0.05). Sleep duration and sleep quality indicators showed significant curvilinear associations (quadratic contrast, P < 0.05); i.e. extremely low and high sleep durations were associated with unfavorable sleep quality and subjective cognitive impairment. Non-recommended low or high sleep durations occur in a substantial proportion of patients with depression, and both were associated with poor sleep quality and subjectively impaired cognitive functions. Clinicians should be aware of these relationships. During hospitalization, a more individualized sleep-wake schedule should be applied. (C) 2016 Elsevier Inc. All rights reserved.
C1 [Mueller, Matthias J.; Olschinski, Christiane] Vitos Clin Ctr Psychiat & Psychotherapy, Giessen, Germany.
   [Mueller, Matthias J.] Justus Liebig Univ Giessen, Giessen, Germany.
   [Kundermann, Bernd; Cabanel, Nicole] Vitos Clin Psychiat & Psychotherapy Giessen, Giessen, Germany.
C3 Justus Liebig University Giessen
RP Müller, MJ (corresponding author), Licher Str 106, D-35394 Giessen, Germany.
EM mjmueller@vitos-giessen-marburg.de
RI Kundermann, Bernd/I-3967-2017
CR [Anonymous], SLEEP DUR REC
   [Anonymous], SOMNOLOGIE
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NR 50
TC 9
Z9 10
U1 0
U2 13
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0883-9417
EI 1532-8228
J9 ARCH PSYCHIAT NURS
JI Arch. Psychiatr. Nurs.
PD FEB
PY 2017
VL 31
IS 1
BP 77
EP 82
DI 10.1016/j.apnu.2016.08.008
PG 6
WC Nursing; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Psychiatry
GA EK6YL
UT WOS:000394072100014
PM 28104063
DA 2025-06-11
ER

PT J
AU Akin, Y
   Karasu, M
   Deniz, A
   Mirzaoglu,
   Bolayir, HA
AF Akin, Yusuf
   Karasu, Mehdi
   Deniz, Abdulmelik
   Mirzaoglu, Cetin
   Bolayir, Hasan Ata
TI Predictive value of the systemic immune inflammatory index in cardiac
   syndrome x
SO BMC CARDIOVASCULAR DISORDERS
LA English
DT Article
DE Cardiac syndrome x; Systemic immune-inflammation index; Predictiveness
ID LYMPHOCYTE RATIO; ASSOCIATION; NEUTROPHIL
AB IntroductionPatients with normal coronary arteries in whom increased vasospasm cannot be detected with the stress test should be evaluated in terms of cardiac syndrome x (CSX). Inflammatory systems are effective in endothelial activation and dysfunction in CSX. The systemic immune inflammation index (SII) is thought to be an important factor in determining the course of diseases, especially in infectious diseases or other diseases, as an indicator of the inflammation process. The aim of this study is to determine the role of SII levels in the diagnosis of CSX disease.MethodsThe study group included 80 patients who applied to the cardiology department of Firat University with typical anginal complaints between October 2021 and April 2022, and were diagnosed with ischemia after the myocardial perfusion scan, and then coronary angiography was performed and normal coronary arteries were observed.ResultsWhen the study and control groups were examined according to age, gender and body mass index, hypertension, smoking, diabetes mellitus, dyslipidemia and family history, no statistical significant difference was observed between the groups. It was observed that there was a significant difference between the high sensitive C- reactive protin levels of the individuals in the study and control groups (p = 0.028). SII levels measured in samples taken from patients were significantly higher than control subjects (p = 0.003). SII cutoff at admission was 582 with 82% sensitivity and 84% specificity (area under the curve 0.972; 95% CI:0.95-0.98;p < 0.001).ConclusionIt has been demonstrated that systemic SII parameters, which can be simply calculated with the data obtained from the complete blood count and do not require additional costs, can contribute to the prediction of CSX disease.
C1 [Akin, Yusuf] Firat Univ, Dept Cardiol, Fac Med, Elazig, Turkiye.
   [Karasu, Mehdi; Mirzaoglu, Cetin] Fethi Sekin Sehir Hastanesi, Dept Cardiol, Elazig, Turkiye.
   [Deniz, Abdulmelik] Fatsa State Hosp, Dept Cardiol, Ordu, Turkiye.
   [Bolayir, Hasan Ata] Malatya Turgut Ozal Univ, Dept Cardiol, Kardiyol ABD, Malatya, Turkiye.
C3 Firat University; Fatsa State Hospital; Malatya Turgut Ozal University
RP Karasu, M (corresponding author), Fethi Sekin Sehir Hastanesi, Dept Cardiol, Elazig, Turkiye.
EM mehdikarasu@yahoo.com
RI Bolayir, Hasan/AAF-4988-2021; karasu, mehdi/ABK-4661-2022
OI KARASU, MEHDI/0000-0003-1713-3451; Mirzaoglu, Cetin/0000-0001-5702-1847
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NR 35
TC 4
Z9 4
U1 0
U2 8
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1471-2261
J9 BMC CARDIOVASC DISOR
JI BMC Cardiovasc. Disord.
PD MAR 23
PY 2023
VL 23
IS 1
AR 146
DI 10.1186/s12872-023-03157-3
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA C1LO2
UT WOS:000959619300004
PM 36959528
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Zhang, TY
   Yi, XYL
   Li, J
   Zheng, XA
   Xu, H
   Liao, DZ
   Ai, JZ
AF Zhang, Tianyi
   Yi, Xianyanling
   Li, Jin
   Zheng, Xiaonan
   Xu, Hang
   Liao, Dazhou
   Ai, Jianzhong
TI Vitamin E intake and multiple health outcomes: an umbrella review
SO FRONTIERS IN PUBLIC HEALTH
LA English
DT Review
DE vitamin E; health outcomes; umbrella review; meta-analyses; intake
ID DOSE-RESPONSE METAANALYSIS; OXIDATIVE STRESS; CARDIOVASCULAR-DISEASE;
   ANTIOXIDANT VITAMINS; E SUPPLEMENTATION; LUNG-CANCER; RISK; ASSOCIATION;
   RATS; 6-HYDROXYDOPAMINE
AB Background: The benefits of vitamin E (VE) for multiple health outcomes have been well evaluated in many recent studies.Objective: The purpose of this umbrella review was to conduct a systematic evaluation of the possible associations between VE intake and various health outcomes.Methods: We systematically searched various databases, such as PubMed, Embase, and the Web of Science, to identify related meta-analyses of observational studies and randomized trials. We estimated the effect size of each association by using the random or fixed effects models and the 95% confidence intervals. We used standard approaches to evaluate the quality of the articles (AMSTAR) and classified the evidence into different levels of quality (GRADE).Results: A total of 1,974 review articles were searched, and 27 articles with 28 health outcomes were yielded according to our exclusion criteria. The intake of VE was inversely associated with the risk of breast cancer, lung cancer, esophageal cancer, gastric cancer, pancreatic cancer, kidney cancer, bladder cancer, cervical neoplasms, cardiovascular disease, Parkinson's disease, depression, age-related cataracts, metabolic syndrome, and fracture. Overall, most of the quality of the evidence was low or very low. Three outcomes (stroke, age-related cataracts, obesity) were identified as having a "moderate" level of quality. The AMSTAR scores for all health outcomes ranged from 5 to 10.Conclusion: Our study revealed that VE intake is beneficially related to multiple health outcomes. However, future studies on recommended doses and recommended populations of VE are also needed.Systematic review registration, identifier: CRD42022339571.
C1 [Zhang, Tianyi; Yi, Xianyanling; Li, Jin; Zheng, Xiaonan; Xu, Hang; Liao, Dazhou; Ai, Jianzhong] Sichuan Univ, West China Hosp, Inst Urol, Dept Urol, Chengdu, Peoples R China.
C3 Sichuan University
RP Ai, JZ (corresponding author), Sichuan Univ, West China Hosp, Inst Urol, Dept Urol, Chengdu, Peoples R China.
EM jianzhong.ai@scu.edu.cn
RI li, yf/KHX-1148-2024
OI wang, haoyu/0009-0001-2467-5331
FU National Natural Science Foundation of China [82070784, 81702536];
   Science and Technology Department of Sichuan Province, China
   [2022JDRC0040]
FX This study was supported by grants from the National Natural Science
   Foundation of China (82070784 and 81702536) to JA and a grant from the
   Science and Technology Department of Sichuan Province, China
   (2022JDRC0040) to JA.
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NR 66
TC 9
Z9 9
U1 1
U2 8
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 2296-2565
J9 FRONT PUBLIC HEALTH
JI Front. Public Health
PD JUL 13
PY 2023
VL 11
AR 1035674
DI 10.3389/fpubh.2023.1035674
PG 12
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA N2MM4
UT WOS:001035415700001
PM 37522003
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Dominguez-Rodriguez, A
   Abreu-Gonzalez, P
   Avanzas, P
   Gomez, M
   Kaski, JC
AF Dominguez-Rodriguez, Alberto
   Abreu-Gonzalez, Pedro
   Avanzas, Pablo
   Angeles Gomez, Maria
   Kaski, Juan Carlos
TI Elevated circulating soluble form of CD40 ligand in patients with
   cardiac syndrome X
SO ATHEROSCLEROSIS
LA English
DT Article
DE Cardiac syndrome X; Soluble CD40 ligand; Inflammation; C-reactive
   protein; White blood cells
ID C-REACTIVE PROTEIN; CHEST-PAIN; PLATELET AGGREGABILITY; COMBINED
   THERAPY; CORONARY; INFLAMMATION; SIMVASTATIN; ACTIVATION; EXERCISE;
   DISEASE
AB Background: The presence of effort induced angina, positive exercise stress test responses and angio-graphically normal coronary arteries defines cardiac syndrome X (CSX). Its pathogenesis, although mostly attributed to endothelial dysfunction and coronary microcirculation abnormalities, is incompletely understood. The soluble CD40 ligand (sCD40L) has multiple autocrine, paracrine and endocrine actions that may lead to endothelial dysfunction and atherothrombosis. We sought to investigate the relationship among sCD40L levels and ischemic burden in patients with CSX and whether sCD40L levels are increased in patients with CSX compared to control subjects.
   Methods: We assessed 30 prospectively enrolled patients with CSX and 28 apparently healthy subjects matched for coronary risk factors. All CSX patients and control subjects underwent myocardial perfusion scintigraphy. The summed difference score is taken to be an index of ischemic burden. This was classified as mildly, moderately and severely abnormal. White blood cells, sCD40L and C-reactive protein (CRP) concentrations were measured at peak exercise.
   Results: At peak exercise, sCD40L levels were significantly greater in CSX patients than in the control group (P = 0.008). Similarly, white blood cell count and CRP levels were higher in patients with CSX than in normal controls (P = 0.02). After multivariable adjustment, sCD40L (P = 0.03) was the only independent predictor of severe ischemic burden in CSX patients.
   Conclusions: The present study showed for the first time that sCD40L is associated with ischemic burden in patients with CSX. The potential role of this inflammatory molecule in the pathogenesis of CSX deserves investigation in future studies. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
C1 [Dominguez-Rodriguez, Alberto] Hosp Univ Canarias, Dept Cardiol, E-38320 Tenerife, Spain.
   [Abreu-Gonzalez, Pedro] Univ La Laguna, Dept Physiol, Tenerife, Spain.
   [Avanzas, Pablo] Hosp Univ Cent Asturias, Dept Cardiol, Oviedo, Spain.
   [Angeles Gomez, Maria] Hosp Univ Canarias, Dept Nucl Med, E-38320 Tenerife, Spain.
   [Kaski, Juan Carlos] St Georges Univ London, Div Cardiac & Vasc Sci, Cardiovasc Biol Res Ctr, London, England.
C3 Universidad de la Laguna; University Hospital of the Canary Islands;
   Universidad de la Laguna; Central University Hospital Asturias;
   Universidad de la Laguna; University Hospital of the Canary Islands;
   City St Georges, University of London; St Georges University London
RP Dominguez-Rodriguez, A (corresponding author), Hosp Univ Canarias, Dept Cardiol, Ofra S-N La Cuesta, E-38320 Tenerife, Spain.
EM adrvdg@hotmail.com
RI Kaski, Juan Carlos/LKM-8031-2024; Abreu-Gonzalez, Pedro/AAC-7790-2020;
   Avanzas, Pablo/B-6811-2008
OI Avanzas, Pablo/0000-0002-4958-6108
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NR 36
TC 10
Z9 10
U1 0
U2 4
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0021-9150
EI 1879-1484
J9 ATHEROSCLEROSIS
JI Atherosclerosis
PD DEC
PY 2010
VL 213
IS 2
BP 637
EP 641
DI 10.1016/j.atherosclerosis.2010.09.031
PG 5
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 688RM
UT WOS:000284869700049
PM 20980002
DA 2025-06-11
ER

PT J
AU Singh, RB
   Pella, D
   Mechirova, V
   Otsuka, K
AF Singh, RB
   Pella, D
   Mechirova, V
   Otsuka, K
TI Can brain dysfunction be a predisposing factor for metabolic syndrome?
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Article; Proceedings Paper
CT 4th International Symposium Workshop on Circadian Rhythms and Clinical
   Chronotherapy
CY NOV 08, 2003
CL Tokyo, JAPAN
DE insulin resistance; brain disease; diet; nutrition; n-3 fatty acids;
   brain development; brain-heart connection
ID HEART-RATE-VARIABILITY; ACUTE MYOCARDIAL-INFARCTION;
   TUMOR-NECROSIS-FACTOR; POLYUNSATURATED FATTY-ACIDS; AUTONOMIC
   NERVOUS-SYSTEM; PLACEBO-CONTROLLED TRIAL; BLOOD-PRESSURE;
   NEUROPEPTIDE-Y; SYNDROME-X; DOUBLE-BLIND
AB The various mechanisms that may explain the association between brain dysfunction and the pathogenesis of metabolic syndrome (MS) leading to cardiovascular disease and type 2 diabetes have been reviewed. A Medline search was conducted until September 2003, and articles published in various national and international journals were reviewed. Experts working in the field were also consulted. Compelling evidence was found that saturated and total fat and low dietary n-3 fatty acids and other long-chain polyunsaturated fatty acids (PUFAs) in conjunction with sedentary behavior and mental stress combined with various personality traits can enhance sympathetic activity and increase the secretion of catecholamine, cortisol and serotonin, all of which appear to be underlying mechanisms involved in MS. Excess secretion of these neurotransmitters in conjunction with underlying long-chain PUFA deficiency may damage the neurons in the ventromedial hypothalamus and insulin receptors in the brain, in particular during fetal life, infancy and childhood, and lead to their dysfunction. Since 30-50% of the fatty acids in the brain are long-chain PUFAs, especially omega-3 fatty acids which are incorporated in the cell membrane phospholipids, it is possible that their supplementation may have a protective effect. Omega-3 fatty acids are also known to enhance parasympathetic activity and to increase the secretion of anti-inflammatory cytokines as well as acetylecholine in the hippocampus. It is possible that a marginal deficiency of long-chain PUFAs, especially n-3 fatty acids, due to poor dietary intake during the critical period of brain growth and development in the fetus, and later in the infant and also possibly in the child, adolescent and adult may enhance the release of tumor necrosis factor-alpha (TNF-alpha) interleukin (IL)- 1, 2 and 6 and cause neuronal dysfunction. Experimental studies indicate that ventromedial hypothalamic lesions in rats induce hyperphagia, resulting in glucose intolerance and insulin resistance. Treatment with neuropeptide Y abolished hyperphagia and ob mRNA (leptin mRNA) in this animal model. Long-term infusion of norepinephrine and serotonin into the ventromedial hypothalamus impaired pancreatic islet function inasmuch as ventromedial hypothalamic norepinephrine and serotonin levels were elevated in hyperinsulinemic and insulin-resistant animals. Treatment with insulin was associated with restoration of hypothalamic neurotransmitter abnormalities, indicating that ventromedial hypothalamus dysfunction can impair pancreatic beta cells resulting in metabolic abnormalities consistent with MS. Treatment with omega-3 fatty acids, beta blockers, ACE inhibitors, estrogen, and meditation may have a beneficial effect on insulin receptors and ventromedial hypothalamic dysfunction. However, no definite or precise insight into the pathophysiological link between MS, brain function and nutrition is available. Despite this, epidemiological studies and intervention trials indicate that treatment with n-3 fatty acids may be adopted in clinical practice and used to direct therapy for prevention of type 2 diabetes, hypertension, coronary artery disease (CAD), and atherosclerosis, thereby indicating that MS may also respond to this treatment. (C) 2004 Elsevier SAS. All rights reserved.
C1 Hosp Med, Meerut, Uttar Pradesh, India.
   Subharti Med Coll, Res Ctr, Meerut, Uttar Pradesh, India.
   FNSP, Interna Klin, Kosice, Slovakia.
   Tokyo Womens Med Univ, Dept Med, Tokyo, Japan.
C3 Tokyo Women's Medical University
RP Hosp Med, Meerut, Uttar Pradesh, India.
EM icn2005@mickyonline.com
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NR 115
TC 20
Z9 20
U1 1
U2 19
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD OCT
PY 2004
VL 58
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BP S56
EP S68
DI 10.1016/S0753-3322(04)80011-8
PG 13
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA 875YG
UT WOS:000225458400011
PM 15754841
DA 2025-06-11
ER

PT J
AU Basnet, S
   Merikanto, I
   Lahti, T
   Männistö, S
   Laatikainen, T
   Vartiainen, E
   Partonen, T
AF Basnet, Syaron
   Merikanto, Ilona
   Lahti, Tuuli
   Mannisto, Satu
   Laatikainen, Tiina
   Vartiainen, Erkki
   Partonen, Timo
TI Seasonal variations in mood and behavior associate with common chronic
   diseases and symptoms in a population-based study
SO PSYCHIATRY RESEARCH
LA English
DT Article
DE Cardiovascular; Chronic; Complex diseases; Depressive
ID PATTERN ASSESSMENT QUESTIONNAIRE; OBSTRUCTIVE PULMONARY-DISEASE;
   AFFECTIVE-DISORDER; RISK-FACTORS; MYOCARDIAL-INFARCTION; WINTER
   DEPRESSION; BLOOD-PRESSURE; MEDICATION ADHERENCE; GENERAL-POPULATION;
   METABOLIC SYNDROME
AB The purpose of this study was to assess how seasonality is associated with some of the most common non-communicable diseases (NCDs) in the general Finnish population. The global seasonality score (GSS) was used to measure the magnitude of seasonality in 4689 participants, in addition to which they reported the extent to which the seasonal variations in mood and behavior were experienced as a problem. Regression models and the odds ratios were adopted to analyze the associations adjusted for a range of covariates. Seventy percent of the participants had seasonal variations in sleep duration, social activity, mood, or energy level, and forty percent those in weight and appetite. Angina pectoris and depression were significantly associated with seasonality throughout the analysis. Hypertension, high cholesterol levels, diabetes, other (than rheumatoid) joint diseases and other (than depressive) psychological illnesses were significantly associated with experiencing a problem due to the seasonal variations, with an increase in the GSS, and with seasonal affective disorder and its subsyndromal form. The co-occurrence of the seasonal variations in mood and behavior with certain common NCDs warrants future research to have insights into the etiology and potentially shared pathways and mechanisms of action. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
C1 [Basnet, Syaron; Merikanto, Ilona; Lahti, Tuuli; Mannisto, Satu; Laatikainen, Tiina; Vartiainen, Erkki; Partonen, Timo] Natl Inst Hlth & Welf, Dept Hlth, Helsinki, Finland.
   [Basnet, Syaron; Lahti, Tuuli] Univ Turku, Dept Behav Sci & Philosophy, SF-20500 Turku, Finland.
   [Merikanto, Ilona] Univ Helsinki, Dept Biosci, Helsinki, Finland.
   [Merikanto, Ilona] Orton Orthopaed Hosp, Helsinki, Finland.
   [Lahti, Tuuli] Univ Helsinki, Dept Publ Hlth, Helsinki, Finland.
C3 Finland National Institute for Health & Welfare; University of Turku;
   University of Helsinki; University of Helsinki
RP Partonen, T (corresponding author), Natl Inst Hlth & Welf, Dept Hlth, Helsinki, Finland.
EM timo.partonen@thl.fi
RI lahti, tuuli/A-9620-2011; Laatikainen, Tiina/ABD-6622-2021; Partonen,
   Timo/G-1105-2012; merikanto, ilona/AAF-2395-2021
OI Laatikainen, Tiina/0000-0002-6614-4782; Merikanto,
   Ilona/0000-0002-1222-6678; lahti, tuuli/0000-0003-2311-2980
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NR 81
TC 21
Z9 21
U1 0
U2 15
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0165-1781
J9 PSYCHIAT RES
JI Psychiatry Res.
PD APR 30
PY 2016
VL 238
BP 181
EP 188
DI 10.1016/j.psychres.2016.02.023
PG 8
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA DL0ZT
UT WOS:000375362300029
PM 27086231
DA 2025-06-11
ER

PT J
AU Kandaz, C
   Önal, B
   Özen, D
   Demir, B
   Akkan, AG
   Özyazgan, S
AF Kandaz, Cemre
   Onal, Burak
   Ozen, Deniz
   Demir, Bulent
   Akkan, A. Gokhan
   Ozyazgan, Sibel
TI Investigation of MTHFR gene C677T polymorphism in cardiac syndrome X
   patients
SO JOURNAL OF CLINICAL LABORATORY ANALYSIS
LA English
DT Article
DE C677T; cardiac syndrome X; microvascular dysfunction; MTHFR;
   polymorphism
ID METHYLENETETRAHYDROFOLATE REDUCTASE GENE; ANGINA-PECTORIS; MICROVASCULAR
   DYSFUNCTION; CLINICAL PRESENTATION; HOMOCYSTEINE; WOMEN; MORTALITY;
   VARIANTS; MUTATION; DISEASE
AB BackgroundDefinition of Cardiac Syndrome X (CSX) refers to groups of patients with positive exercise stress test and normal epicardial coronary arteries on coronary angiography accompanied by chest pain. Although the etiology of CSX is not completely understood, there is a common consensus that its pathophysiology may be associated with endothelial dysfunction resulting in impaired coronary flow. Some polymorphisms observed on the MTHFR gene cause inactivation of the MTHFR enzyme, leading to hyperhomocysteinemia and homocysteinuria, which are prominent risk factors of cardiovascular and cerebrovascular diseases. It was aimed to explain the association of the endothelial dysfunction, which is thought to play a role in the pathophysiology of CSX, with C677T polymorphism on MTHFR gene based on genetic basis.
   MethodsA total of 176 CSX patients and 196 healthy subjects with similar age and clinical features were compared in terms of C677T polymorphism of the MTHFR gene.
   Results and ConclusionThere was no significant difference in terms of MTHFR gene C677T polymorphism between CSX patients and controls. When genotypic distribution was compared based on gender in both patients and controls, no significant difference was found between male and female subjects (P>.05). As fasting blood sugar and urea values were significantly higher, alanine aminotransferase and gamma-glutamyl transferase levels were significantly lower in the patients than the controls (P<.05). Described family story of the patients was significantly higher than the controls (P<.05). These suggest that homocysteine metabolism in CSX is not directly related to the endothelial dysfunction and thus the effect on the microvascular circulation.
C1 [Kandaz, Cemre; Ozen, Deniz; Akkan, A. Gokhan; Ozyazgan, Sibel] Istanbul Univ, Cerrahpasa Fac Med, Dept Med Pharmacol, Istanbul, Turkey.
   [Onal, Burak] Istinye Univ, Dept Pharmacol & Clin Pharmacol, Fac Med, Istanbul, Turkey.
   [Demir, Bulent] Bakirkoy Dr Sadi Konuk Training & Res Hosp, Dept Cardiol, Istanbul, Turkey.
C3 Istanbul University - Cerrahpasa; Istanbul University; Istinye
   University; Bakirkoy Dr. Sadi Konuk Research & Training Hospital
RP Önal, B (corresponding author), Istinye Univ, Dept Pharmacol & Clin Pharmacol, Fac Med, Istanbul, Turkey.
EM bonal@istinye.edu.tr
RI AKKAN, AHMET/C-7331-2019; Demir, Bulent/KVC-1688-2024; Özyazgan,
   Sibel/C-7404-2019; Ozen, Deniz/K-3979-2018
OI Demir, Bulent/0000-0003-1767-408X; Onal, Burak/0000-0002-7846-875X;
   Ozyazgan, Sibel/0000-0002-2511-3541; Ozen, Deniz/0000-0002-3095-1208
CR Agrawal S, 2016, HEART FAIL CLIN, V12, P141, DOI 10.1016/j.hfc.2015.08.012
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NR 28
TC 2
Z9 2
U1 0
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 0887-8013
EI 1098-2825
J9 J CLIN LAB ANAL
JI J. Clin. Lab. Anal.
PD FEB
PY 2018
VL 32
IS 2
AR e22247
DI 10.1002/jcla.22247
PG 5
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA FW2CM
UT WOS:000425109100023
PM 28481466
OA Green Published
DA 2025-06-11
ER

PT J
AU Li, L
   Ding, LG
   Zheng, LH
   Wu, LM
   Hu, ZC
   Liu, LM
   Zhang, ZX
   Zhou, LK
   Yao, Y
AF Li, Le
   Ding, Ligang
   Zheng, Lihui
   Wu, Lingmin
   Hu, Zhicheng
   Liu, Limin
   Zhang, Zhuxin
   Zhou, Likun
   Yao, Yan
TI U-shaped association between stress hyperglycemia ratio and risk of
   all-cause mortality in cardiac ICU
SO DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS
LA English
DT Article
DE Stress hyperglycemia; Stress hyperglycemia ratio; Outcomes; Restricted
   cubic spline
ID METABOLIC SYNDROME; INSULIN; HEART; DISEASE; IMPACT
AB Background:Stress hyperglycemia has been associated with poor prognosis in patients admitted to the cardiac intensive care unit (ICU). Recently, the stress hyperglycemia ratio (SHR) has been proposed to reflect true acute hyperglycemic. This study aimed to investigate the relationship between SHR and prognosis of patients in the cardiac ICU. Methods:A retrospective analysis was conducted on a cohort of 5,564 patients admitted to the cardiac ICU. The participants were divided into seven groups based on their SHR levels. SHR was calculated as admission blood glucose/[(28.7 x HbA1c %) - 46.7]. The primary outcomes of this study were 28-day all-cause mortality. Results:During the follow-up period, 349 (6.3%) patients succumbed within 28 days. A U-shaped correlation between SHR and mortality persisted, even after adjusting for other confounding variables, with a discernible inflection point at 0.95. When SHR surpassed 0.95, each standard deviation (SD) increase corresponded to a 1.41-fold elevation in the risk of mortality (odds ratio [OR]: 1.41, 95% CI: 1.25 to 1.59). In contrast, when SHR fell below 0.95, each SD increment correlated with a significantly reduced risk of mortality (OR: 0.56, 95% CI: 0.34 to 0.91). Conclusion:There was a U-shaped association between SHR and short -term mortality in patients in the cardiac ICU. The inflection point of SHR for poor prognosis was identified at an SHR value of 0.95.
C1 [Li, Le; Ding, Ligang; Zheng, Lihui; Wu, Lingmin; Hu, Zhicheng; Liu, Limin; Zhang, Zhuxin; Zhou, Likun; Yao, Yan] Chinese Acad Med Sci, Fuwai Hosp, Peking Union Med Coll, Natl Ctr Cardiovasc Dis, Beijing, Peoples R China.
   [Yao, Yan] Chinese Acad Med Sci, Fuwai Hosp, Beijing 100037, Peoples R China.
C3 Chinese Academy of Medical Sciences - Peking Union Medical College;
   Peking Union Medical College; Fu Wai Hospital - CAMS; Chinese Academy of
   Medical Sciences - Peking Union Medical College; Fu Wai Hospital - CAMS
RP Yao, Y (corresponding author), Chinese Acad Med Sci, Fuwai Hosp, Beijing 100037, Peoples R China.
EM ianyao@263.net.cn
FU Medical and Health Technology Innovation Project of Chinese Academy of
   Medical Sciences [2021-CXGC09-1]
FX This study was supported by Medical and Health Technology Innovation
   Project of Chinese Academy of Medical Sciences (2021-CXGC09-1) .
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NR 28
TC 12
Z9 13
U1 0
U2 1
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 1871-4021
EI 1878-0334
J9 DIAB MET SYND CLIN R
JI DIABET. METAB. SYNDR. CLIN. RES. REV.
PD JAN
PY 2024
VL 18
IS 1
AR 102932
DI 10.1016/j.dsx.2023.102932
EA DEC 2023
PG 6
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA FO6G1
UT WOS:001146813800001
PM 38147811
DA 2025-06-11
ER

PT J
AU Alatalo, PI
   Koivisto, HM
   Hietala, JP
   Bloigu, RS
   Niemelä, OJ
AF Alatalo, Paivikki I.
   Koivisto, Heidi M.
   Hietala, Johanna P.
   Bloigu, Risto S.
   Niemela, Onni J.
TI Gender-dependent impacts of body mass index and moderate alcohol
   consumption on serum uric acid-an index of oxidant stress status?
SO FREE RADICAL BIOLOGY AND MEDICINE
LA English
DT Article
DE Ethanol; Obesity; Urate; Oxidative stress; Estrogen; Free radicals
ID GAMMA-GLUTAMYL-TRANSFERASE; OXIDATIVE STRESS; ALANINE AMINOTRANSFERASE;
   ANTIOXIDANT CAPACITY; METABOLIC SYNDROME; LIVER-DISEASE; RED WINE; RISK;
   SEX; HYPERTENSION
AB Uric acid seems to be causally involved in a variety of medical disorders involving oxidative stress. Although alcohol abuse and obesity are known to increase serum uric acid, the interactions between moderate drinking, adiposity, and uric acid metabolism have remained poorly understood. We examined serum uric acid concentrations from 2062 apparently healthy volunteers (970 men, 1092 women) reporting either no alcohol (abstainers) or <40 g of ethanol consumption per day (moderate drinkers). The study population was further classified according to BMI as follows: <19 (underweight), 19-25 (normal weight), 25-30 (overweight), and >30 (obese). Serum uric acid concentrations in male moderate drinkers were significantly higher, and in females they were lower, than in the corresponding groups of abstainers. In the BMI-based subgroups, the highest concentrations were found in those who were overweight or obese. Significant two-factor interactions occurred between gender and drinking status (p<0.001) and between gender and BMI (p<0.02). Serum uric acid also correlated with indices of hepatocellular health (GGT, ALT, AST). The data indicate distinct gender-dependent impacts of alcohol consumption and BMI on serum uric acid. These findings should be applicable to the assessment of oxidative stress status and associated morbidity in alcohol consumers and individuals with excess body weight. (C) 2009 Elsevier Inc. All rights reserved.
C1 [Alatalo, Paivikki I.; Koivisto, Heidi M.; Hietala, Johanna P.; Niemela, Onni J.] Seinajoki Cent Hosp, Dept Lab Med, FIN-60220 Seinajoki, Finland.
   [Alatalo, Paivikki I.; Koivisto, Heidi M.; Hietala, Johanna P.; Niemela, Onni J.] Seinajoki Cent Hosp, Med Res Unit, FIN-60220 Seinajoki, Finland.
   [Alatalo, Paivikki I.; Koivisto, Heidi M.; Hietala, Johanna P.; Niemela, Onni J.] Univ Tampere, FIN-60220 Seinajoki, Finland.
   [Bloigu, Risto S.] Univ Oulu, Med Informat Grp, Oulu, Finland.
C3 Seinajoki Central Hospital; Seinajoki Central Hospital; Tampere
   University; University of Oulu
RP Niemelä, OJ (corresponding author), Seinajoki Cent Hosp, Dept Lab Med, FIN-60220 Seinajoki, Finland.
EM onni.niemela@epshp.fi
RI Kangastupa, Päivikki/JZZ-0468-2024
OI Kangastupa, Paivikki/0000-0003-0695-6073
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NR 63
TC 19
Z9 19
U1 0
U2 5
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0891-5849
EI 1873-4596
J9 FREE RADICAL BIO MED
JI Free Radic. Biol. Med.
PD APR 15
PY 2009
VL 46
IS 8
BP 1233
EP 1238
DI 10.1016/j.freeradbiomed.2009.02.002
PG 6
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 432KW
UT WOS:000265132900028
PM 19439211
DA 2025-06-11
ER

PT J
AU Verma, M
   Grover, S
   Chakrabarti, S
AF Verma, Meha
   Grover, Sandeep
   Chakrabarti, Subho
TI Effectiveness of clozapine on quality of life and functioning in
   patients with treatment-resistant schizophrenia
SO NORDIC JOURNAL OF PSYCHIATRY
LA English
DT Article
DE Clozapine; effectiveness; quality of life; disability; functioning
ID OBSESSIVE-COMPULSIVE SCALE; METABOLIC SYNDROME;
   ELECTROCONVULSIVE-THERAPY; SUBJECTIVE EXPERIENCES; PEOPLE;
   ANTIPSYCHOTICS; RISPERIDONE; SYMPTOMS; INSIGHT; NAIVE
AB Background Although it is well known that treatment with clozapine is associated with improvement in core symptoms of schizophrenia, little information is available about its impact on other outcome variables. Accordingly, this study aimed to evaluate the short term (3 months) effectiveness of clozapine in patients with treatment-resistant schizophrenia (TRS) in terms of quality of life, disability, and level of functioning. Methods This naturalistic follow-up study evaluated 52 participants at the baseline and three months (+/- 1 week) after initiation of clozapine (prospective assessment) on Positive and Negative Syndrome Scale for schizophrenia, Calgary Depression Scale for Schizophrenia, Yale-Brown Obsessive-Compulsive Scale Checklist and Scale, Clinical Global Impression (CGI) scale, Beck Cognitive Insight Scale (BCIS), Scale to Assess Unawareness of Mental Disorders (SUMD), Social Occupational Functioning Scale - SOFS, Functioning Assessment Short Test (FAST), Indian Disability Evaluation and Assessment Scale (IDEAS), World Health Organisation Quality Of Life-BREF (WHOQOL-BREF) and Self-report Quality of Life Measure for people with schizophrenia. Results Treatment with clozapine led to significant improvement in the quality of life, functioning, and disability; reduction in psychopathology (positive, negative, general psychology, depression), the severity of illness, compulsive behavior, and improvement in insight including cognitive insight. Conclusions Treatment with clozapine leads to improvement in core symptoms of schizophrenia and is also associated with significant improvement in the quality of life, functioning, and disability.
C1 [Verma, Meha; Grover, Sandeep; Chakrabarti, Subho] Post Grad Inst Med Educ & Res, Dept Psychiat, Chandigarh, India.
C3 Post Graduate Institute of Medical Education & Research (PGIMER),
   Chandigarh
RP Grover, S (corresponding author), Post Grad Inst Med Educ & Res, Dept Psychiat, Chandigarh, India.
EM drsandeepg2002@yahoo.com
OI chakrabarti, subho/0000-0001-6023-2194; Grover,
   Sandeep/0000-0002-2714-2055
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NR 52
TC 18
Z9 18
U1 2
U2 4
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0803-9488
EI 1502-4725
J9 NORD J PSYCHIAT
JI Nord. J. Psychiatr.
PD FEB 1
PY 2021
VL 75
IS 2
BP 135
EP 144
DI 10.1080/08039488.2020.1811374
EA SEP 2020
PG 10
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA QA9PQ
UT WOS:000568943900001
PM 32915089
DA 2025-06-11
ER

PT J
AU Malik, S
   Singh, R
   Arora, G
   Dangol, A
   Goyal, S
AF Malik, Sahil
   Singh, Ravinder
   Arora, Govind
   Dangol, Akriti
   Goyal, Sanjay
TI Biomarkers of Major Depressive Disorder: Knowing is Half the Battle
SO CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE
LA English
DT Review
DE Major depressive disorder; Brain-derived neurotrophic factor;
   Insulin-like growth factor I; IL-1 beta; Mood disorders
ID NECROSIS-FACTOR-ALPHA; GROWTH-FACTOR SYSTEM; INFLAMMATORY CYTOKINES;
   SEROTONIN TRANSPORTER; MOOD DISORDERS; METABOLIC SYNDROME; SYMPTOM
   SEVERITY; GENE-EXPRESSION; NMDA RECEPTOR; SERUM-LEVELS
AB Major depressive disorder (MDD) is a heterogeneous disease which is why there are currently no specific methods to accurately test the severity, endophenotype or therapy response. This lack of progress is partly attributed to the complexity and variability of depression, in association with analytical variability of clinical literature and the wide number of theoretically complex biomarkers. The literature accessible, indicates that markers involved in inflammatory, neurotrophic and metabolic processes and components of neurotransmitters and neuroendocrine systems are rather strong indicators to be considered clinically and can be measured through genetic and epigenetic, transcriptomic and proteomic, metabolomics and neuroimaging assessments. Promising biologic systems/markers found were i.e., growth biomarkers, endocrine markers, oxidant stress markers, proteomic and chronic inflammatory markers, are discussed in this review. Several lines of evidence suggest that a portion of MDD is a dopamine agonist-responsive subtype. This review analyzes concise reports on the pathophysiological biomarkers of MDD and therapeutic reactions via peripheral developmental factors, inflammative cytokines, endocrine factors and metabolic markers. Various literatures also support that endocrine and metabolism changes are associated with MDD. Accumulating evidence suggests that at least a portion of MDD patients show characteristics pathological changes regarding different clinical pathological biomarkers. By this review we sum up all the different biomarkers playing an important role in the detection or treatment of the different patients suffering from MDD. The review also gives an overview of different biomarker's playing a potential role in modulating effect of MDD.
C1 [Malik, Sahil; Singh, Ravinder; Arora, Govind; Dangol, Akriti] Chitkara Univ, Chitkara Coll Pharm, Chandigarh Patiala Natl Highway,NH-64, Rajpura 140401, Punjab, India.
   [Goyal, Sanjay] Govt Med Coll, Dept Internal Med, Patiala, Punjab, India.
C3 Chitkara University, Punjab
RP Singh, R (corresponding author), Chitkara Univ, Chitkara Coll Pharm, Chandigarh Patiala Natl Highway,NH-64, Rajpura 140401, Punjab, India.
EM ravi.jaura@gmail.com
RI Singh, Dr. Puneetpal/AGH-6494-2022
OI Dangol, Akriti/0000-0002-5495-1034; Singh, Ravinder/0000-0003-1565-9740
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NR 118
TC 33
Z9 35
U1 2
U2 24
PU KOREAN COLL NEUROPSYCHOPHARMACOLOGY
PI SEOUL
PA RN 1003 OFFICETEL 40, 63-RO YEONGDEUNGPO-GU, SEOUL, 150-731, SOUTH KOREA
SN 1738-1088
EI 2093-4327
J9 CLIN PSYCHOPHARM NEU
JI Clin. Psychopharmacol. Neurosci.
PD FEB
PY 2021
VL 19
IS 1
BP 12
EP 25
DI 10.9758/cpn.2021.19.1.12
PG 14
WC Neurosciences; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pharmacology & Pharmacy
GA QB4VB
UT WOS:000614138000002
PM 33508785
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Aleksandrova, K
   Koelman, L
   Rodrigues, CE
AF Aleksandrova, Krasimira
   Koelman, Liselot
   Rodrigues, Caue Egea
TI Dietary patterns and biomarkers of oxidative stress and inflammation: A
   systematic review of observational and intervention studies
SO REDOX BIOLOGY
LA English
DT Review
DE Dietary patterns; Oxidative stress; Inflammation; Biomarkers; Systematic
   review
ID FATTY LIVER-DISEASE; MEDITERRANEAN DIET; METABOLIC SYNDROME; DNA-DAMAGE;
   CARDIOVASCULAR-DISEASE; PRIMARY PREVENTION; LIFE-STYLE; DASH DIET;
   ANTIOXIDANTS; CANCER
AB Introduction: Oxidative stress and inflammation are known to play a critical role in ageing and chronic disease development and could therefore represent important targets for developing dietary strategies for disease prevention. We aimed to systematically review the results from observational studies and intervention trials published in the last 5 years on the associations between dietary patterns and biomarkers of oxidative stress and inflammation. Methods: A systematic search of the PubMed, MEDLINE and Web of Science (January 2015 to October 2020) was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Methodological quality of selected studies was evaluated based on the NUTRIGRADE and BIOCROSS assessment tools. Results: In total, 29 studies among which 16 observational studies and 13 intervention studies were found eligible for review. Overall, results indicated an inverse association between plant-based diets - the Mediterranean and Dietary Approaches to Stop Hypertension (DASH) diet - and oxidative stress and proinflammatory biomarkers. In observational studies, inverse associations were further revealed for the vegetarian diet, the USDA Healthy Eating Index (HEI) - based diet and the paleolithic diet, whereas a positive association was seen for western and fast food diets. Quality assessment suggested that majority of dietary intervention studies (n = 12) were of low to moderate quality. Conclusions: This study provides evidence that the plant-based dietary patterns are associated with lowered levels of oxidative stress and inflammation and may provide valid means for chronic disease prevention. Future largescale intervention trials using validated biomarkers are warranted to confirm these findings.
C1 [Aleksandrova, Krasimira; Koelman, Liselot; Rodrigues, Caue Egea] German Inst Human Nutr Potsdam Rehbruecke DIfE, Dept Nutr & Gerontol, Nutr Immun & Metab Senior Scientist Grp, Nuthetal, Germany.
   [Aleksandrova, Krasimira] Leibniz Inst Prevent Res & Epidemiol, Dept Epidemiol Methods & Etiol Res, Bremen, Germany.
   [Aleksandrova, Krasimira] Univ Bremen, Fac Human & Hlth Sci, Bremen, Germany.
   [Rodrigues, Caue Egea] Free Univ Berlin, Inst Pharm, Berlin, Germany.
C3 Leibniz Association; Deutsches Institut fur Ernahrungsforschung
   Potsdam-Rehbrucke (DIfE); Leibniz Association; Leibniz Institute for
   Prevention Research & Epidemiology (BIPS); University of Bremen; Free
   University of Berlin
RP Aleksandrova, K (corresponding author), Leibniz Inst Prevent Res & Epidemiol, Dept Epidemiol Methods & Etiol Res, Bremen, Germany.
EM aleksandrova@leibniz-bips.de
OI Egea Rodrigues, Caue/0000-0001-9882-673X; Koelman,
   Liselot/0000-0002-5969-8760
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NR 122
TC 258
Z9 268
U1 10
U2 95
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2213-2317
J9 REDOX BIOL
JI Redox Biol.
PD JUN
PY 2021
VL 42
AR 101869
DI 10.1016/j.redox.2021.101869
EA APR 2021
PG 16
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA RS5WQ
UT WOS:000643849500010
PM 33541846
OA Green Published, gold
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Muñoz-Pérez, D
   González-Correa, C
   Muñoz, EY
   Sánchez-Giraldo, M
   Carmona-Hernández, J
   López-Miranda, J
   Camargo, A
   Rangel-Zúñiga, O
AF Maria Munoz-Perez, Diana
   Helena Gonzalez-Correa, Clara
   Astudillo Munoz, Elcy Yaned
   Sanchez-Giraldo, Maite
   Carlos Carmona-Hernandez, Juan
   Lopez-Miranda, Jose
   Camargo, Antonio
   Alberto Rangel-Zuniga, Oriol
TI Effect of 8-Week Consumption of a Dietary Pattern Based on Fruit,
   Avocado, Whole Grains, and Trout on Postprandial Inflammatory and
   Oxidative Stress Gene Expression in Obese People
SO NUTRIENTS
LA English
DT Article
DE gene expression; healthy diet; inflammation; obesity; oxidative stress
ID MEDITERRANEAN DIET; METABOLIC SYNDROME; ADIPOSE-TISSUE; TARGET GENES;
   PPAR-GAMMA; FISH-OIL; PROFILE; FAT; METAANALYSIS
AB Overweight and obesity constitute a major global public health problem. Healthy dietary patterns induce changes at the molecular level. Currently, there are no studies evaluating the effect of a diet based on fruit, avocado, whole grains, and trout (FAWGT diet) on the expression of obesity-related genes. This randomized controlled crossover study included 44 obese Colombians with BMI >= 30 kg/m(2) who followed either a FAWGT diet or a usual diet (UD) characterized by a high intake of saturated fat and foods rich in processed carbohydrates. After 8 weeks of intervention, a postprandial expression study of inflammation and oxidative stress-related genes was carried out with a real-time PCR. The intervention with a FAWGT diet decreased the expression of inflammatory (NFKB1, IL6, IL1 beta) and oxidative stress (NFE2L2) genes compared with the intake of the UD. Finally, the postprandial expression of NFkB1 was positively correlated with triglyceride levels after a dietary intervention with the FAWGT diet and the IL1 beta gene, and likewise with insulin levels after following the usual diet. The consumption of the FAWGT diet for 8 weeks reduced the inflammatory status; thus, it can be considered a valid alternative to other healthy diets, since it induces beneficial changes on the genes involved in inflammation and oxidative stress in obese people.
C1 [Maria Munoz-Perez, Diana; Helena Gonzalez-Correa, Clara] Univ Caldas, Dept Ciencias Basicasde Salud, Grp Invest Nutr Metab & Segur Alimentaria, Manizales 170004, Colombia.
   [Maria Munoz-Perez, Diana] Univ Libre Pereira, Fac Ciencias Salud, Grp Invest NutriOma, Pereira 660001, Colombia.
   [Astudillo Munoz, Elcy Yaned] Univ Libre Pereira, Fac Ciencias Salud, Grp Invest Gerencia Cuidado, Pereira 660001, Colombia.
   [Sanchez-Giraldo, Maite; Lopez-Miranda, Jose; Camargo, Antonio; Alberto Rangel-Zuniga, Oriol] Reina Sofia Univ Hosp, Dept Internal Med, Lipids & Atherosclerosis Unit, Cordoba 14004, Spain.
   [Sanchez-Giraldo, Maite; Lopez-Miranda, Jose; Camargo, Antonio; Alberto Rangel-Zuniga, Oriol] Univ Cordoba, Dept Med & Surg Sci, Cordoba 14004, Spain.
   [Sanchez-Giraldo, Maite; Lopez-Miranda, Jose; Camargo, Antonio; Alberto Rangel-Zuniga, Oriol] Maimonides Biomed Res Inst Cordoba IMIBIC, Cordoba 14004, Spain.
   [Carlos Carmona-Hernandez, Juan] Univ Manizales, Linea Metab Nutr Polifenoles MeNutrO, Grp Invest Med, Manizales 170004, Colombia.
   [Lopez-Miranda, Jose; Camargo, Antonio; Alberto Rangel-Zuniga, Oriol] Inst Salud Carlos III, CIBER Fisiopatol Obes & Nutr CIBEROBN, Madrid 28029, Spain.
C3 Universidad de Caldas; Universidad de Cordoba; Universidad de Manizales;
   Instituto de Salud Carlos III; CIBER - Centro de Investigacion Biomedica
   en Red; CIBEROBN
RP González-Correa, C (corresponding author), Univ Caldas, Dept Ciencias Basicasde Salud, Grp Invest Nutr Metab & Segur Alimentaria, Manizales 170004, Colombia.; Camargo, A; Rangel-Zúñiga, O (corresponding author), Reina Sofia Univ Hosp, Dept Internal Med, Lipids & Atherosclerosis Unit, Cordoba 14004, Spain.; Camargo, A; Rangel-Zúñiga, O (corresponding author), Univ Cordoba, Dept Med & Surg Sci, Cordoba 14004, Spain.; Camargo, A; Rangel-Zúñiga, O (corresponding author), Maimonides Biomed Res Inst Cordoba IMIBIC, Cordoba 14004, Spain.; Camargo, A; Rangel-Zúñiga, O (corresponding author), Inst Salud Carlos III, CIBER Fisiopatol Obes & Nutr CIBEROBN, Madrid 28029, Spain.
EM antonio.camargo@imibic.org
RI Gonzalez-Correa, Clara/AAN-8895-2021; Lopez-Miranda, Jose/Y-8306-2019;
   Camargo Garcia, Antonio/G-9720-2015; Carmona-Hernandez, Juan
   Carlos/O-9786-2014
OI Rangel-Zuniga, Oriol Alberto/0000-0003-3495-5705; Lopez-Miranda,
   Jose/0000-0002-8844-0718; Camargo Garcia, Antonio/0000-0002-0415-4184;
   Carmona-Hernandez, Juan Carlos/0000-0001-9944-4573; Gonzalez-Correa,
   Clara Helena/0000-0001-5621-2166; Sanchez Giraldo,
   Maite/0009-0009-1851-0467
FU Colombian Ministry of Science and Innovation (COLCIENCIAS); University
   of Caldas [0406716, 0179217, 14010104]; Instituto de Salud Carlos III
   [CP14/00114, PI19/00299, DTS19/00007, PI22/00925, CP19/00142,
   PI22/01020]
FX This work was funded by the Colombian Ministry of Science and Innovation
   (COLCIENCIAS) with a grant awarded under the National PhD Call 647 of
   2014. This study was funded by the University of Caldas in the "General
   call for the financing of Research, Innovation and Creation of the
   University of Caldas 2015 (0406716)" and the "General call for project
   financing of Research, research-creation and innovation 2016 (0179217)"
   to D.M.M.-P. and C.H.G.-C. Convocatoria 7 Universidad Libre Seccional
   Pereira 2017 (14010104) to D.M.M.-P. This study was also partially
   supported by the Instituto de Salud Carlos III under the grants
   CP14/00114, PI19/00299, DTS19/00007, and PI22/00925 to A.C.; CP19/00142
   and PI22/01020 to O.A. R.-Z.. O.A.R.-Z. and A.C. are supported by an
   ISCIII research contract (Programa Miguel-Servet CP19/00142 and
   CPII19/00007, respectively).
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NR 44
TC 3
Z9 3
U1 1
U2 10
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JAN
PY 2023
VL 15
IS 2
AR 306
DI 10.3390/nu15020306
PG 13
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 8R4GI
UT WOS:000927851300001
PM 36678177
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Jin, W
   Li, CR
   Yang, SH
   Song, SY
   Hou, WW
   Song, Y
   Du, QY
AF Jin, Wei
   Li, Chunrun
   Yang, Shihui
   Song, Shiyi
   Hou, Weiwei
   Song, Yang
   Du, Quanyu
TI Hypolipidemic effect and molecular mechanism of ginsenosides: a review
   based on oxidative stress
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Review
DE natural medicine; ginsenosides; oxidative stress; lipid metabolism
ID KOREAN RED GINSENG; ACTIVATED PROTEIN-KINASE; FATTY LIVER-DISEASE;
   PANAX-GINSENG; INSULIN-RESISTANCE; NONALCOHOLIC STEATOHEPATITIS;
   METABOLIC SYNDROME; GUT MICROBIOTA; CARDIOLIPIN; NRF2
AB Hyperlipidemia is considered a risk factor for cardiovascular and endocrine diseases. However, effective approaches for treating this common metabolic disorder remain limited. Ginseng has traditionally been used as a natural medicine for invigorating energy or "Qi" and has been demonstrated to possess antioxidative, anti-apoptotic, and anti-inflammatory properties. A large number of studies have shown that ginsenosides, the main active ingredient of ginseng, have lipid-lowering effects. However, there remains a lack of systematic reviews detailing the molecular mechanisms by which ginsenosides reduce blood lipid levels, especially in relation to oxidative stress. For this article, research studies detailing the molecular mechanisms through which ginsenosides regulate oxidative stress and lower blood lipids in the treatment of hyperlipidemia and its related diseases (diabetes, nonalcoholic fatty liver disease, and atherosclerosis) were comprehensively reviewed. The relevant papers were search on seven literature databases. According to the studies reviewed, ginsenosides Rb1, Rb2, Rb3, Re, Rg1, Rg3, Rh2, Rh4, and F2 inhibit oxidative stress by increasing the activity of antioxidant enzymes, promoting fatty acid beta-oxidation and autophagy, and regulating the intestinal flora to alleviate high blood pressure and improve the body's lipid status. These effects are related to the regulation of various signaling pathways, such as those of PPARa, Nrf2, mitogen-activated protein kinases, SIRT3/FOXO3/SOD, and AMPK/SIRT1. These findings suggest that ginseng is a natural medicine with lipid-lowering effects.
C1 [Jin, Wei; Hou, Weiwei; Song, Yang] Univ Tradit Chinese Med, Hosp Chengdu, Emergency Dept, Chengdu, Peoples R China.
   [Li, Chunrun; Yang, Shihui; Song, Shiyi] Chengdu Univ Tradit Chinese Med, Sch Clin Med, Sichuan, Peoples R China.
   [Du, Quanyu] Univ Tradit Chinese Med, Hosp Chengdu, Endocrinol Dept, Chengdu, Peoples R China.
C3 Chengdu University of Traditional Chinese Medicine
RP Song, Y (corresponding author), Univ Tradit Chinese Med, Hosp Chengdu, Emergency Dept, Chengdu, Peoples R China.; Du, QY (corresponding author), Univ Tradit Chinese Med, Hosp Chengdu, Endocrinol Dept, Chengdu, Peoples R China.
EM songyang1989@cdutcm.edu.cn; quanydu@163.com
RI Yang, Shihui/AAE-4100-2020
FU Science and Technology Development Foundation of the Hospital of Chengdu
   University of Traditional Chinese Medicine [21HL05, 20YY11]; Sichuan
   Financial Society [CJJ2022119, 2022NSFSC1277]; Sichuan Natural Science
   Foundation;  [79]
FX This work was supported by Science and Technology Development Foundation
   of the Hospital of Chengdu University of Traditional Chinese Medicine
   (NO.21HL05; NO. 20YY11); Sichuan Financial Society (2022) No.79 TCM
   Talent Training Program (CJJ2022119); and Sichuan Natural Science
   Foundation (NO. 2022NSFSC1277).
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NR 154
TC 15
Z9 17
U1 19
U2 80
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD APR 28
PY 2023
VL 14
AR 1166898
DI 10.3389/fphar.2023.1166898
PG 21
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA G1GJ5
UT WOS:000986722800001
PM 37188264
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Orsolini, L
   Sarchione, F
   Vellante, F
   Fornaro, M
   Matarazzo, I
   Martinotti, G
   Valchera, A
   Di Nicola, M
   Carano, A
   Di Giannantonio, M
   Perna, G
   Olivieri, L
   De Berardis, D
AF Orsolini, Laura
   Sarchione, Fabiola
   Vellante, Federica
   Fornaro, Michele
   Matarazzo, Ilaria
   Martinotti, Giovanni
   Valchera, Alessandro
   Di Nicola, Marco
   Carano, Alessandro
   Di Giannantonio, Massimo
   Perna, Giampaolo
   Olivieri, Luigi
   De Berardis, Domenico
TI Protein-C Reactive as Biomarker Predictor of Schizophrenia Phases of
   Illness? A Systematic Review
SO CURRENT NEUROPHARMACOLOGY
LA English
DT Review
DE C-reactive protein; schizophrenia; psychosis; inflammation; chronic
   illness; systematic review
ID SUBSTANCE USE DISORDERS; LOW-GRADE INFLAMMATION; OXIDATIVE STRESS;
   BIPOLAR DISORDER; SERUM-LEVELS; CARDIOVASCULAR-DISEASE; COGNITIVE
   IMPAIRMENT; UNIPOLAR DEPRESSION; METABOLIC SYNDROME; PRENATAL EXPOSURE
AB Background: Schizophrenia is a complex illness in which genetic, environmental, and epigenetic components have been implicated. However, recently, psychiatric disorders appear to be related to a chronic inflammatory state, at the level of specific cerebral areas which have been found as well impaired and responsible for schizophrenia symptomatology. Hence, a role of inflammatory mediators and cytokines has been as well defined. Accordingly, the role of an acute inflammatory phase protein, the C-reactive protein (CRP) has been recently investigated.
   Objective: The objective of the present study is to evaluate how PCR may represent a biomarker in schizophrenia, i.e. correlated with illness phases and/or clinical manifestation and/or psychopathological severity.
   Methods: A systematic review was here carried out by searching the following keywords ((C-reactive protein AND ((schizophrenia) OR (psychotic disorder))) for the topics 'PCR' and 'Schizophrenia', by using MESH terms.
   Results: An immune dysfunction and inflammation have been described amongst schizophrenic patients. Findings reported elevated CRP levels in schizophrenia, mainly correlated with the severity of illness and during the recrudescent phase. CRP levels are higher when catatonic features, negative symptomatology and aggressiveness are associated. CRP levels appeared not to be related to suicidal behaviour and ideation.
   Conclusion: CRP and its blood levels have been reported higher amongst schizophrenic patients, by suggesting a role of inflammation in the pathogenesis of schizophrenia. Further studies are needed to better understand if CRP may be considered a biomarker in schizophrenia.
C1 [Orsolini, Laura] Sch Life & Med Sci, Drug Misuse & Novel Psychoact Subst Res Unit, Psychopharmacol, Coll Lane Campus, Hatfield AL10 9AB, Herts, England.
   [Orsolini, Laura] KOS Grp, Neomesia Psychiat Rehabil Clin, Milan, Italy.
   [Orsolini, Laura; Valchera, Alessandro] Polyedra Res, Teramo, Italy.
   [Sarchione, Fabiola; Vellante, Federica; Matarazzo, Ilaria; Martinotti, Giovanni; Valchera, Alessandro; Di Giannantonio, Massimo] Univ G DAnnunzio, Chair Psychiat, Dept Neurosci & Imaging, Chieti, Italy.
   [Fornaro, Michele; Valchera, Alessandro] Sch Med Federico II Naples, Dept Neurosci Reprod Sci & Odontostomatol, Naples, Italy.
   [Valchera, Alessandro] Villa S Giuseppe Hosp, Hermanas Hosp, Ascoli Piceno, Italy.
   [Di Nicola, Marco] Univ Cattolica Sacro Cuore, Inst Psychiat & Psychol, Fdn Policlin Univ A Gemelli, Rome, Italy.
   [Carano, Alessandro] Hosp Madonna Del Soccorso, NHS, Dept Mental Hlth, Psychiat Serv Diag & Treatment, San Benedetto Tronto, Ascoli Piceno, Italy.
   [Perna, Giampaolo] FoRiPsi, Dept Clin Neurosci, Hermanas Hosp, Albese Con Cassano, Como, Italy.
   [Perna, Giampaolo] Univ Maastricht, Dept Psychiat & Neuropsychol, Maastricht, Netherlands.
   [Perna, Giampaolo] Univ Miami, Leonard Miller Sch Med, Dept Psychiat & Behav Sci, Coral Gables, FL 33124 USA.
   [Olivieri, Luigi; De Berardis, Domenico] Hosp G Mazzini, ASL Teramo 4, Psychiat Serv Diag & Treatment, NHS,Dept Mental Hlth, Teramo, Italy.
C3 G d'Annunzio University of Chieti-Pescara; University of Naples Federico
   II; Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli;
   Maastricht University; University of Miami
RP De Berardis, D (corresponding author), Hosp G Mazzini, Psychiat Serv Diag & Treatment, Dept Mental Hlth, Natl Hlth Serv, Piazza Italia 1, I-64100 Teramo, Italy.
EM domenico.deberardis@aslteramo.it
RI Martinotti, Giovanni/AAC-7592-2022; Di Nicola, Marco/HKP-2003-2023;
   Orsolini, Laura/J-1478-2015; Orsolini, Laura/C-9553-2014; Perna,
   Giampaolo/K-5194-2013; De Berardis, Domenico/F-9343-2018
OI Olivieri, Luigi/0009-0003-5716-4508; Orsolini,
   Laura/0000-0002-6882-3770; Perna, Giampaolo/0000-0002-8166-0785; Di
   Nicola, Marco/0000-0001-7457-0426; De Berardis,
   Domenico/0000-0003-4415-5058
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NR 135
TC 72
Z9 73
U1 1
U2 12
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1570-159X
EI 1875-6190
J9 CURR NEUROPHARMACOL
JI Curr. Neuropharmacol.
PY 2018
VL 16
IS 5
BP 583
EP 606
DI 10.2174/1570159X16666180119144538
PG 24
WC Neurosciences; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Pharmacology & Pharmacy
GA GF4EU
UT WOS:000431916000007
PM 29357805
OA Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Han, RJ
   Kitlinska, JB
   Munday, WR
   Gallicano, GI
   Zukowska, Z
AF Han, Ruijun
   Kitlinska, Joanna B.
   Munday, William R.
   Gallicano, G. Ian
   Zukowska, Zofia
TI Stress Hormone Epinephrine Enhances Adipogenesis in Murine Embryonic
   Stem Cells by Up-Regulating the Neuropeptide Y System
SO PLOS ONE
LA English
DT Article
ID MECHANISMS LINKING OBESITY; WHITE ADIPOSE-TISSUE; IN-VIVO;
   INSULIN-RESISTANCE; SELF-RENEWAL; FAT; DIFFERENTIATION; ADIPOCYTES;
   COTRANSMISSION; THERMOGENESIS
AB Prenatal stress, psychologically and metabolically, increases the risk of obesity and diabetes in the progeny. However, the mechanisms of the pathogenesis remain unknown. In adult mice, stress activates NPY and its Y2R in a glucocorticoid-dependent manner in the abdominal fat. This increased adipogenesis and angiogenesis, leading to abdominal obesity and metabolic syndrome which were inhibited by intra-fat Y2R inactivation. To determine whether stress elevates NPY system and accelerates adipogenic potential of embryo, here we "stressed" murine embryonic stem cells (mESCs) in vitro with epinephrine (EPI) during their adipogenic differentiation. EPI was added during the commitment stage together with insulin, and followed by dexamethasone in the standard adipogenic differentiation medium. Undifferentiated embryonic bodies (EBs) showed no detectable expression of NPY. EPI markedly up-regulated the expression NPY and the Y1R at the commitment stage, followed by increased Y2R mRNA at the late of the commitment stage and the differentiation stage. EPI significantly increased EB cells proliferation and expression of the preadipocyte marker Pref-1 at the commitment stage. EPI also accelerated and amplified adipogenic differentiation detected by increasing the adipocyte markers FABP4 and PPAR gamma mRNAs and Oil-red O-staining at the end of the differentiation stage. EPI-induced adipogenesis was completely prevented by antagonists of the NPY receptors (Y1R+Y2R+Y5R), indicating that it was mediated by the NPY system in mESC's. Taken together, these data suggest that stress may play an important role in programing ESCs for accelerated adipogenesis by altering the stress induced hormonal regulation of the NPY system.
C1 [Han, Ruijun; Zukowska, Zofia] Univ Minnesota, Dept Integrat Biol & Physiol, Stress Physiol Ctr, Minneapolis, MN 55455 USA.
   [Han, Ruijun; Kitlinska, Joanna B.; Munday, William R.; Zukowska, Zofia] Georgetown Univ, Med Ctr, Dept Physiol, Washington, DC 20007 USA.
   [Han, Ruijun; Kitlinska, Joanna B.; Munday, William R.; Zukowska, Zofia] Georgetown Univ, Med Ctr, Dept Biophys, Washington, DC 20007 USA.
   [Gallicano, G. Ian] Georgetown Univ, Med Ctr, Dept Biochem, Washington, DC 20007 USA.
   [Gallicano, G. Ian] Georgetown Univ, Med Ctr, Dept Cellular & Mol Biol, Washington, DC 20007 USA.
C3 University of Minnesota System; University of Minnesota Twin Cities;
   Georgetown University; Georgetown University; Georgetown University;
   Georgetown University
RP Han, RJ (corresponding author), Univ Minnesota, Dept Integrat Biol & Physiol, Stress Physiol Ctr, Minneapolis, MN 55455 USA.
EM rhan@umn.edu
RI Han, Ruijun/K-6614-2012
FU United States National Institutes of Health [R01HL067357, R37HL055310]
FX This work was supported by United States National Institutes of Health
   grants R01HL067357 and R37HL055310 to Z.Z. The funders had no role in
   study design, data collection and analysis, decision to publish, or
   preparation of the manuscript.
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NR 56
TC 25
Z9 28
U1 0
U2 12
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAY 3
PY 2012
VL 7
IS 5
AR e36609
DI 10.1371/journal.pone.0036609
PG 7
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 959VF
UT WOS:000305343400047
PM 22570731
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Yu, YC
   Wang, L
   Delguste, F
   Durand, A
   Guilbaud, A
   Rousselin, C
   Schmidt, AM
   Tessier, F
   Boulanger, E
   Neviere, R
AF Yu, Yichi
   Wang, Lei
   Delguste, Florian
   Durand, Arthur
   Guilbaud, Axel
   Rousselin, Clementine
   Schmidt, Ann Marie
   Tessier, Frederic
   Boulanger, Eric
   Neviere, Remi
TI Advanced glycation end products receptor RAGE controls myocardial
   dysfunction and oxidative stress in high-fat fed mice by sustaining
   mitochondrial dynamics and autophagy-lysosome pathway
SO FREE RADICAL BIOLOGY AND MEDICINE
LA English
DT Article
DE Receptor for advanced glycation end products (RAGE); Mitochondria;
   Oxidative stress; Heart; Autophagy; High fat diet
ID METABOLIC SYNDROME; CELL-DEATH; MECHANISMS; EXPRESSION; MITOPHAGY;
   ROLES; AGES; RESPIRATION; ENDPRODUCTS; ACTIVATION
AB Oxidative stress and mitochondrial dysfunction are recognized as major contributors of cardiovascular damage in diabetes and high fat diet (HFD) fed mice. Blockade of receptor for advanced glycation end products (RAGE) attenuates vascular oxidative stress and development of atherosclerosis. We tested whether HFD-induced myocardial dysfunction would be reversed in RAGE deficiency mice, in association with changes in oxidative stress damage, mitochondrial respiration, mitochondrial fission and autophagy-lysosomal pathway. Cardiac antioxidant capacity was upregulated in RAGE(-)/(-) mice under normal diet as evidenced by increased superoxide dismutase and sirtuin mRNA expressions. Mitochondrial fragmentation and mitochondrial fission protein Drp1 and Fis1 expressions were increased in RAGE(-)/(-) mice. Autophagy-related protein expressions and cathepsin- L activity were increased in RAGE(-)/(-) mice suggesting sustained autophagy-lysosomal flux. HFD induced mitochondrial respiration defects, cardiac contractile dysfunction, disrupted mitochondrial dynamics and autophagy inhibition, which were partially prevented in RAGE(-)/(-) mice. Our results suggest that cardioprotection against HFD in RAGE(-)/(-) mice include reactivation of autophagy, as inhibition of autophagic flux by chloroquine fully abrogated beneficial myocardial effects and its stimulation by rapamycin improved myocardial function in HFD wild type mice. As mitochondrial fission is necessary to mitophagy, increased fragmentation of mitochondrial network in HFD RAGE(-)/(-) mice may have facilitated removal of damaged mitochondria leading to better mitochondrial quality control. In conclusion, modulation of RAGE pathway may improve mitochondrial damage and myocardial dysfunction in HFD mice. Attenuation of cardiac oxidative stress and maintenance of healthy mitochondria population ensuring adequate energy supply may be involved in myocardial protection against HFD.
C1 [Yu, Yichi; Wang, Lei; Delguste, Florian; Durand, Arthur; Guilbaud, Axel; Rousselin, Clementine; Tessier, Frederic; Boulanger, Eric; Neviere, Remi] Lille Univ, INSERM U995, LIRIC Team Glycat Inflammat Aging, Lille, France.
   [Yu, Yichi; Wang, Lei] Shanghai Jiao Tong Univ, Sch Med, Shanghai, Peoples R China.
   [Durand, Arthur; Rousselin, Clementine; Boulanger, Eric] Univ Hosp CHU Lille, F-59000 Lille, France.
   [Schmidt, Ann Marie] NYU, Dept Med, Langone Med Ctr, Diabet Res Ctr, 550 1St Ave, New York, NY 10016 USA.
   [Neviere, Remi] Univ Antilles, Univ Hosp CHU Martinique, F-97200 Fort De France, France.
C3 Universite de Lille; Institut National de la Sante et de la Recherche
   Medicale (Inserm); Shanghai Jiao Tong University; Universite de Lille;
   CHU Lille; NYU Langone Medical Center; New York University; CHU
   Martinique
RP Neviere, R (corresponding author), Univ Antilles, Univ Hosp CHU Martinique, F-97200 Fort De France, France.
EM remi.neviere@chu-martinique.fr
RI ; tessier, frederic/G-3729-2018; guilbaud, axel/N-2483-2018
OI BOULANGER, Eric/0000-0002-5204-2849; tessier,
   frederic/0000-0001-8096-5715; Neviere, Remi/0000-0002-7966-0110;
   guilbaud, axel/0000-0001-6007-1618; DELGUSTE,
   Florian/0000-0003-1199-7291
FU INSERM [U995]; LIRIC /Team; Lille University, France; Digest Science
   Fondation; Fondation de recherche reconnue d'utilite publique sur les
   maladies de l'appareil digestif et la nutrition, France; University
   Hospital CHU of Martinique; Fort de France, France
FX This work was supported by: (1) INSERM U995, LIRIC /Team "Glycation:
   from inflammation to aging", Lille University, France - (2) Digest
   Science Fondation, Fondation de recherche reconnue d'utilite publique
   sur les maladies de l'appareil digestif et la nutrition, France (3)
   University Hospital CHU of Martinique, Fort de France, F-97200, France.
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NR 49
TC 55
Z9 61
U1 1
U2 33
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0891-5849
EI 1873-4596
J9 FREE RADICAL BIO MED
JI Free Radic. Biol. Med.
PD NOV
PY 2017
VL 112
BP 397
EP 410
DI 10.1016/j.freeradbiomed.2017.08.012
PG 14
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA FI3BD
UT WOS:000411829300035
PM 28826719
DA 2025-06-11
ER

PT J
AU Di Emidio, G
   Santin, SJ
   D'Alessandro, AM
   Vetuschi, A
   Sferra, R
   Artini, PG
   Carta, G
   Falone, S
   Amicarelli, F
   Tatone, C
AF Di Emidio, Giovanna
   Santin, Silvano Junior
   D'Alessandro, Anna Maria
   Vetuschi, Antonella
   Sferra, Roberta
   Artini, Paolo Giovanni
   Carta, Gaspare
   Falone, Stefano
   Amicarelli, Fernanda
   Tatone, Carla
TI SIRT1 participates in the response to methylglyoxal-dependent glycative
   stress in mouse oocytes and ovary
SO BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
LA English
DT Article
DE Methylglyoxal; SIRTI; Oocyte; Advanced glycation end product (AGE);
   Meiotic spindle; PCOS (polycystic ovarian syndrome)
ID END-PRODUCTS; EMBRYONIC-DEVELOPMENT; IN-VITRO; PARTHENOGENETIC
   ACTIVATION; INSULIN-RESISTANCE; METABOLIC SYNDROME; DICARBONYL STRESS;
   FOLLICULAR-FLUID; OXIDATIVE STRESS; CARBONYL STRESS
AB Methylglyoxal (MG), a highly reactive dicarbonyl derived from metabolic processes, is the most powerful precursor of advanced glycation end products (AGEs). Glycative stress has been recently associated with ovarian dysfunctions in aging and PCOS syndrome. We have investigated the role of the NAD'-dependent Class HI deacetylase SIRT1 in the adaptive response to MG in mouse oocytes and ovary. In mouse oocytes, MG induced up-expression of glyoxalase 1 (Glol) and glyoxalase 2 (Glo2) genes, components of the main MG detoxification system, whereas inhibition of SIRT1 by Ex527 or sirtinol reduced this response. In addition, the inhibition of SIRTI worsened the effects of MG on oocyte maturation rates, while SIRT1 activation by resveratrol counteracted MG insult. Ovaries from female mice receiving 100 mg/kg MG by gastric administration for 28 days (MG mice) exhibited increased levels of SIRT1 along with over-expression of catalase, superoxide dismutase 2, SIRT3, PGClc: and mtTFA. Similar levels of MG-derived AGES were observed in the ovaries from MG and control groups, along with enhanced protein expression of glyoxalase 1 in MG mice. Oocytes ovulated by MG mice exhibited atypical meiotic spindles, a condition predisposing to embryo aneuploidy. Our results from mouse oocytes revealed for the first time that SIRT1 could modulate MG scavenging by promoting expression of glyoxalases. The finding that up-regulation of glyoxalase I is associated with that of components of a SIRT1 functional network in the ovaries of MG mice provides strong evidence that SIRTI participates in the response to methylglyoxaldependent glycative stress in the female gonad.
C1 [Di Emidio, Giovanna; Santin, Silvano Junior; D'Alessandro, Anna Maria; Carta, Gaspare; Falone, Stefano; Amicarelli, Fernanda; Tatone, Carla] Univ Aquila, Dept Life Hlth & Environm Sci, Laquila, Italy.
   [Di Emidio, Giovanna; Carta, Gaspare; Tatone, Carla] San Salvatore Hosp, Infertil Serv, I-67100 Laquila, Italy.
   [Vetuschi, Antonella; Sferra, Roberta] Univ Aquila, Dept Biotechnol & Appl Clin Sci, Laquila, Italy.
   [Artini, Paolo Giovanni] Univ Pisa, Div Obstet & Gynaecol, Dept Reprod Med & Child Dev, Pisa, Italy.
   [Amicarelli, Fernanda] CNR, Inst Translat Pharmacol IFT, Laquila, Italy.
C3 University of L'Aquila; University of L'Aquila; University of Pisa;
   Consiglio Nazionale delle Ricerche (CNR); Istituto di Farmacologia
   Traslazionale (IFT-CNR)
RP Tatone, C (corresponding author), Univ Aquila, San Salvatore Hosp, Infertil Serv, Dept Life Hlth & Environm Sci, Via Vetoio, I-67100 Laquila, Italy.
EM carla.tatone@univaq.it
RI ARTINI, PAOLO/AAC-1310-2019; D'Alessandro, Anna/F-5991-2013; Di Emidio,
   Giovanna/ABG-3102-2020; Santini, Silvano Junior/S-5406-2016; Falone,
   Stefano/D-8692-2017
OI Sferra, Roberta/0000-0003-3893-8320; Santini, Silvano
   Junior/0000-0001-6577-5892; Falone, Stefano/0000-0002-5978-0545;
   D'Alessandro, Anna Maria/0000-0002-2212-2207; Di Emidio,
   Giovanna/0000-0001-9442-6923
FU Department of Life, Health and Environmental Sciences, University of
   L'Aquila (RIA 2014-2017); San Salvatore Hospital, L'Aquila
FX The funds for this work were provided by the Department of Life, Health
   and Environmental Sciences, University of L'Aquila (RIA 2014-2017) and
   San Salvatore Hospital, L'Aquila (post-doc fellowship to G.D.).
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NR 73
TC 43
Z9 43
U1 0
U2 19
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0925-4439
EI 1879-260X
J9 BBA-MOL BASIS DIS
JI Biochim. Biophys. Acta-Mol. Basis Dis.
PD JUN 1
PY 2019
VL 1865
IS 6
BP 1389
EP 1401
DI 10.1016/j.bbadis.2019.02.011
PG 13
WC Biochemistry & Molecular Biology; Biophysics; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Cell Biology
GA HZ2VZ
UT WOS:000468708200030
PM 30771486
DA 2025-06-11
ER

PT J
AU Minami, S
   Miura, K
   Ishioka, M
   Morimoto, N
   Isoda, N
   Yamamoto, H
   Iijima, K
AF Minami, Shinichiro
   Miura, Kouichi
   Ishioka, Mitsuaki
   Morimoto, Naoki
   Isoda, Norio
   Yamamoto, Hironori
   Iijima, Katsunori
TI Homocysteine supplementation ameliorates steatohepatitis induced by a
   choline-deficient diet in mice
SO HEPATOLOGY RESEARCH
LA English
DT Article
DE choline deficiency; homocysteine; NASH
ID NONALCOHOLIC FATTY LIVER; CARDIOVASCULAR EVENTS; OXIDATIVE STRESS; GUT
   MICROBIOTA; B-VITAMINS; FOLIC-ACID; RISK; DISEASE; HYPERHOMOCYSTEINEMIA;
   VALIDATION
AB Aim High concentrations of homocysteine are believed to induce lipid synthesis and cell injury through endoplasmic reticulum (ER) stress in metabolic syndrome. However, homocysteine could be used to improve steatohepatitis induced by choline deficiency, in which methyl donors are decreased. The aim of the present study was to clarify the role of the physiological concentration of homocysteine in the development of steatohepatitis induced by choline deficiency. Methods Wild-type mice were fed a choline-deficient amino acid-defined (CDAA) diet with or without homocysteine supplementation for 24 weeks. Liver cells isolated from mice were exposed to homocysteine under choline-deficient conditions. Results Wild-type mice fed the CDAA diet developed steatohepatitis with increased ER stress and decreased S-adenosylmethionine (SAM), a methyl donor. Homocysteine supplementation reduced ER stress and restored hepatic SAM, leading to the improvement of steatohepatitis. In in vitro experiments using primary cultured hepatocytes, the physiological concentration of homocysteine decreased the lipid accumulation and ER stress induced by the choline-deficient conditions. However, hepatocyte death was not induced by a physiological concentration of homocysteine or in choline-deficient medium. Interestingly, tumor necrosis factor (TNF)alpha promoted hepatocyte death under choline-deficient conditions, which was suppressed by homocysteine supplementation. Hepatic macrophages increased the production of TNF alpha under choline-deficient conditions whereas supplementation of SAM reduced the TNF alpha production. Conclusions Homocysteine supplementation ameliorates steatohepatitis by reducing ER stress and increasing SAM in mice fed a CDAA diet. These results were opposite to those of previous reports, which showed that homocysteine induced cell injury.
C1 [Minami, Shinichiro; Miura, Kouichi; Ishioka, Mitsuaki; Iijima, Katsunori] Akita Univ, Grad Sch Med, Dept Gastroenterol, Akita, Japan.
   [Miura, Kouichi; Morimoto, Naoki; Isoda, Norio; Yamamoto, Hironori] Jichi Med Univ, Sch Med, Dept Med, Div Gastroenterol, 3311-1 Yakushiji, Shimotsuke, Tochigi 3290498, Japan.
C3 Akita University; Jichi Medical University
RP Miura, K (corresponding author), Jichi Med Univ, Sch Med, Dept Med, Div Gastroenterol, 3311-1 Yakushiji, Shimotsuke, Tochigi 3290498, Japan.
EM miura385@jichi.ac.jp
OI Ishioka, Mitsuaki/0000-0002-7853-4454
FU Japan Society for the Promotion of Science; Bristol-Myers Squibb
FX WE THANK MASAKI Yuri (Akita University), Masako Watanabe (Jichi Medical
   University), and Yuko Terada (Jichi Medical University) for excellent
   technical assistance. K.M. was supported by a Grant-in-Aid for
   Scientific Research from Japan Society for the Promotion of Science and
   Bristol-Myers Squibb.
CR Ai Y, 2017, NUTRIENTS, V9, P1
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NR 31
TC 14
Z9 13
U1 0
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1386-6346
EI 1872-034X
J9 HEPATOL RES
JI Hepatol. Res.
PD FEB
PY 2019
VL 49
IS 2
BP 189
EP 200
DI 10.1111/hepr.13234
PG 12
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA HL1BL
UT WOS:000458428500007
PM 30048033
DA 2025-06-11
ER

PT J
AU Veiga-Lopez, A
   Pennathur, S
   Kannan, K
   Patisaul, HB
   Dolinoy, DC
   Zeng, LX
   Padmanabhan, V
AF Veiga-Lopez, Almudena
   Pennathur, Subramaniam
   Kannan, Kurunthachalam
   Patisaul, Heather B.
   Dolinoy, Dana C.
   Zeng, Lixia
   Padmanabhan, Vasantha
TI Impact of Gestational Bisphenol A on Oxidative Stress and Free Fatty
   Acids: Human Association and Interspecies Animal Testing Studies
SO ENDOCRINOLOGY
LA English
DT Article
ID ENDOCRINE-DISRUPTING CHEMICALS; HIGH-DENSITY-LIPOPROTEIN; PERINATAL
   EXPOSURE; METABOLIC SYNDROME; PRENATAL EXPOSURE; PREGNANT-WOMEN;
   ADIPOSE-TISSUE; ADULT; ACCUMULATION; HEALTH
AB Bisphenol A (BPA) is a high production volume chemical and an endocrine disruptor. Developmental exposures to BPA have been linked to adult metabolic pathologies, but the pathways through which these disruptions occur remain unknown. This is a comprehensive interspecies association vs causal study to evaluate risks posed by prenatal BPA exposure and to facilitate discovery of biomarkers of relevance to BPA toxicity. Samples from human pregnancies during the first trimester and at term, as well as fetal and/or adult samples from prenatally BPA-treated sheep, rats, and mice, were collected to assess the impact of BPA on free fatty acid and oxidative stress dynamics. Mothers exposed to higher BPA during early to midpregnancy and their matching term cord samples displayed increased 3-nitrotyrosine (NY), a marker of nitrosative stress. Maternal samples had increased palmitic acid, which was positively correlated with NY. Sheep fetuses and adult sheep and rats prenatally exposed to a human-relevant exposure dose of BPA showed increased systemic nitrosative stress. The strongest effect of BPA on circulating free fatty acids was observed in adult mice in the absence of increased oxidative stress. This is the first multispecies study that combines human association and animal causal studies assessing the risk posed by prenatal BPA exposure to metabolic health. This study provides evidence of the induction of nitrosative stress by prenatal BPA in both the mother and fetus at time of birth and is thus supportive of the use of maternal NY as a biomarker for offspring health.
C1 [Veiga-Lopez, Almudena; Padmanabhan, Vasantha] Univ Michigan, Dept Pediat, Ann Arbor, MI 48109 USA.
   [Pennathur, Subramaniam; Zeng, Lixia] Univ Michigan, Dept Internal Med, Ann Arbor, MI 48109 USA.
   [Kannan, Kurunthachalam] New York State Dept Hlth, Wadsworth Ctr, Albany, NY 12201 USA.
   [Patisaul, Heather B.] N Carolina State Univ, Dept Biol Sci, Raleigh, NC 27695 USA.
   [Dolinoy, Dana C.] Univ Michigan, Dept Environm Hlth Sci, Ann Arbor, MI 48109 USA.
C3 University of Michigan System; University of Michigan; University of
   Michigan System; University of Michigan; Wadsworth Center; State
   University of New York (SUNY) System; North Carolina State University;
   University of Michigan System; University of Michigan
RP Padmanabhan, V (corresponding author), Univ Michigan, Dept Pediat, 300 North Ingalls Bldg,Room 1138, Ann Arbor, MI 48109 USA.
EM vasantha@umich.edu
RI Pennathur, Subramaniam/O-7032-2017; Padmanabhan, Vasantha/C-8558-2017;
   Kannan, Kurunthachalam/ACA-0037-2022
OI Padmanabhan, Vasantha/0000-0002-8443-7212; Kannan,
   Kurunthachalam/0000-0002-1926-7456; Pennathur,
   Subramaniam/0000-0003-3628-6883
FU American Recovery and Reinvestment Act supplement to National Institute
   for Environmental Health Sciences (NIEHS) Grant [R01 ES016541]; NIEHS
   [R01 ES016541, P01 ES022844, P30ES017885, R01 ES017005, R01 ES016001,
   R01 ES017524]; United States Environmental Protection Agency (US EPA)
   Grant [RD 83543601]; Molecular Phenotyping Core, MI Nutrition and
   Obesity Center (The National Institute of Diabetes and Digestive and
   Kidney Diseases [NIDDK] grant) [P30DK089503]; Michigan Regional
   Metabolomics Resource Core (NIDDK grant) [U24 DK097153]; National
   Institute of Diabetes and Digestive and Kidney Diseases [P30DK089503,
   P30DK020572] Funding Source: NIH RePORTER; National Institute of
   Environmental Health Sciences [P30ES017885] Funding Source: NIH RePORTER
FX This work was supported by an American Recovery and Reinvestment Act
   supplement to National Institute for Environmental Health Sciences
   (NIEHS) Grant R01 ES016541 (to V.P.), NIEHS grant P01 ES022844, and the
   United States Environmental Protection Agency (US EPA) Grant RD
   83543601. Analytical support for this research was also provided by the
   NIEHS grant P30ES017885. Plasma and tissue samples used in this
   investigation were generated as part of the following grants: human,
   NIEHS R01 ES017005 (to V.P.); sheep, NIEHS R01 ES016541 (to V.P.); rat,
   NIEHS R01 ES016001 (to H.B.P.); and mice, NIEHS R01 ES017524 (D.C.D.).
   Metabolomic measurements were processed through the Molecular
   Phenotyping Core, MI Nutrition and Obesity Center (The National
   Institute of Diabetes and Digestive and Kidney Diseases [NIDDK] grant
   P30DK089503) and Michigan Regional Metabolomics Resource Core (NIDDK
   grant U24 DK097153).
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NR 82
TC 55
Z9 58
U1 0
U2 23
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0013-7227
EI 1945-7170
J9 ENDOCRINOLOGY
JI Endocrinology
PD MAR
PY 2015
VL 156
IS 3
BP 911
EP 922
DI 10.1210/en.2014-1863
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA CG4QS
UT WOS:000353272000014
PM 25603046
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Oliveira, SR
   Kallaur, AP
   Simao, ANC
   Morimoto, HK
   Lopes, J
   Panis, C
   Petenucci, DL
   da Silva, E
   Cecchini, R
   Kairnen-Maciel, DR
   Reiche, EMV
AF Oliveira, Sayonara Rangel
   Kallaur, Ana Paula
   Colado Simao, Andrea Name
   Morimoto, Helena Kaminami
   Lopes, Josiane
   Panis, Carolina
   Petenucci, Diego Lima
   da Silva, Eloisa
   Cecchini, Rubens
   Kairnen-Maciel, Damacio Ramon
   Vissoci Reiche, Edna Maria
TI Oxidative stress in multiple sclerosis patients in clinical remission:
   Association with the expanded disability status scale
SO JOURNAL OF THE NEUROLOGICAL SCIENCES
LA English
DT Article
DE Oxidative stress; Multiple sclerosis; Lipid peroxidation; EDSS; Carbonyl
   protein; Antioxidant
ID TOTAL ANTIOXIDANT CAPACITY; URIC-ACID; METABOLIC SYNDROME; NITRATE
   LEVELS; PLASMA; SERUM; PATHOGENESIS; IMPAIRMENT; PROTEINS
AB Increased levels of oxidative stress markers and/or decreased levels of antioxidant molecules have been described in patients with multiple sclerosis (MS). This imbalance has been implicated in demyelination and axonal damage. The aims of this study were to evaluate oxidative stress in MS patients and to verify its correlation with disability as assessed by the expanded disability status scale (EDSS). This case-controlled study included 91 patients with relapsing-remitting multiple sclerosis (RR-MS) and 196 healthy individuals matched by age, gender, ethnicity, smoking status, and body mass index. Oxidative stress was evaluated by tert-butyl hydroperoxide-initiated chemiluminescence (CL-LOOH), carbonyl protein, nitric oxide metabolites (NOx), total radical-trapping antioxidant parameter (TRAP), sulfhydryl groups of proteins and serum uric acid levels. MS patients exhibited higher plasma levels of CL-LOOH (p<0.0001) and carbonyl protein (p = 0.0081), and lower plasma levels of NOx (p<0.0001), TRAP (p = 0.0088), and sulfhydryl groups (p = 0.0003) compared to the control subjects. A multivariate analysis showed an association between oxidative markers and the presence of MS. Patients with an EDSS >3.5 showed higher CL-LOOH than control subjects (p = 0.0093). A positive correlation was observed between CL-LOOH and EDSS (r = 0.3244, p = 0.0026) and between carbonyl protein and EDSS (r = 03012, p = 0.0041). These results demonstrate that oxidative stress plays an important role in the physiopathology of MS progression. (C) 2012 Elsevier B.V. All rights reserved.
C1 [Colado Simao, Andrea Name] Univ Estadual Londrina, Dept Pathol Clin Anal & Toxicol, Hlth Sci Ctr, BR-86038440 Londrina, Parana, Brazil.
   [Oliveira, Sayonara Rangel; Kallaur, Ana Paula; Lopes, Josiane] Univ Estadual Londrina, Hlth Sci Ctr, Postgrad Program, BR-86038440 Londrina, Parana, Brazil.
   [Petenucci, Diego Lima; da Silva, Eloisa] Univ Estadual Londrina, Hlth Sci Ctr, Pharm Grad Program, BR-86038440 Londrina, Parana, Brazil.
   [Kairnen-Maciel, Damacio Ramon] Univ Estadual Londrina, Dept Clin Med, BR-86038440 Londrina, Parana, Brazil.
C3 Universidade Estadual de Londrina; Universidade Estadual de Londrina;
   Universidade Estadual de Londrina; Universidade Estadual de Londrina
RP Simao, ANC (corresponding author), Univ Estadual Londrina, Dept Pathol Clin Anal & Toxicol, Hlth Sci Ctr, Robert Koch Ave 60, BR-86038440 Londrina, Parana, Brazil.
EM deianame@yahoo.com.br
RI Reiche, EDNa/AAD-4186-2020; kallaur, Ana/AAO-8945-2020; Simão,
   Andrea/AAM-4892-2021; Cecchini, Rubens/D-9811-2013; Reiche, Edna Maria
   Vissoci/C-4102-2013; PANIS, CAROLINA/O-1490-2015
OI Kallaur, Ana Paula/0000-0001-9563-971X; Cecchini,
   Rubens/0000-0001-9941-2344; Reiche, Edna Maria
   Vissoci/0000-0001-6507-2839; PANIS, CAROLINA/0000-0002-0104-4369
FU National Council for Scientific and Technological Development (CNPq);
   State University of Londrina (PROPPG); Bayer HealthCare
FX This study was supported by grants obtained from the Institutional
   Program for Scientific Initiation Scholarship (PIBIC) of the National
   Council for Scientific and Technological Development (CNPq); State
   University of Londrina (PROPPG); and Bayer HealthCare. We thank the
   State University of Londrina, the University Hospital of State
   University of Londrina, and HUTEC for their technical and administrative
   support.
CR Amorini AM, 2009, CLIN BIOCHEM, V42, P1001, DOI 10.1016/j.clinbiochem.2009.03.020
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NR 32
TC 80
Z9 86
U1 0
U2 9
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0022-510X
EI 1878-5883
J9 J NEUROL SCI
JI J. Neurol. Sci.
PD OCT 15
PY 2012
VL 321
IS 1-2
BP 49
EP 53
DI 10.1016/j.jns.2012.07.045
PG 5
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 017DJ
UT WOS:000309570000009
PM 22883481
DA 2025-06-11
ER

PT J
AU Yoo, HY
   Ryu, E
   Kim, JS
   Han, KD
AF Yoo, Hae Young
   Ryu, Eunjung
   Kim, Ji-Su
   Han, Kyung-do
TI Association between Awareness of Nutrition Labels and Menstrual Cycle
   Irregularity in Korean Women: The Fifth Korea National Health and
   Nutrition Examination Survey (2010-2012)
SO JOURNAL OF KOREAN ACADEMY OF NURSING
LA English
DT Article
DE Food labeling; Menstrual cycle; Health literacy
ID FOOD LABEL; RISK; TESTOSTERONE; INFORMATION; OBESITY; WELL
AB Purpose: The aim of this study was to identify the relationship between awareness of nutrition labeling and menstrual cycle irregularity in women from a nationally representative sample of the Korean population. Methods: A cross-sectional analysis was performed using hierarchical multi variable logistic regression analysis models. A total of 4,324 women aged 1954 years from the 20102012 Korean National Health and Nutrition Examination Survey participated in the study. The participants were classified into three groups based on self-report responses to a questionnaire about their awareness of nutrition labels: Reading, Not-Reading, and Not-Knowing Groups. Results: The Reading, Not-Reading, and Not-Knowing Groups comprised 46.4%, 44.9%, and 8.70/0 of the participants, respectively, and 53.6% of the participants had never used nutrition labels. In the Not-Knowing Group, irregular menstrual cycles for more than 3 months were significantly more common than women with irregular menstrual cycles for up to 3 months and women with regular menstrual cycles. Women in the Not-Knowing Group were more likely to exhibit menstrual cycle irregularity (adjusted odds ratio: 1.63, 95% confidence interval: 1.102.41) compared to women in the Reading Group after adjusting for age, body mass index, smoking status, alcohol intake, exercise regularity, stress, depression, suicidal ideation, metabolic syndrome, age at menarche, parity, and use of oral contraceptives. Conclusion: No awareness of nutrition labeling appears to be associated with a higher prevalence of menstrual cycle irregularity in a nationally representative group of Korean women.
C1 [Yoo, Hae Young; Ryu, Eunjung; Kim, Ji-Su] Chung Ang Univ, Dept Nursing, 84 Heuksuk Ro, Seoul 06974, South Korea.
   [Han, Kyung-do] Catholic Univ, Coll Med, Dept Biostat, Seoul, South Korea.
C3 Chung Ang University; Catholic University of Korea
RP Ryu, E (corresponding author), Chung Ang Univ, Dept Nursing, 84 Heuksuk Ro, Seoul 06974, South Korea.
EM go2ryu@cau.ac.kr
RI Kim, Kyung/I-5501-2015; Han, Kyungdo/JKH-7628-2023; Ryu,
   Eunjung/AAH-8482-2019
OI RYU, EUNJUNG/0000-0002-2232-6082; Kim, Ji-Su/0000-0002-9512-1934
FU Basic Science Research Program through the National Research Foundation
   of Korea (NRF)-Ministry of Science, ICT and future Planning
   [2014R1A2A2A01006008]
FX This research was supported by Basic Science Research Program through
   the National Research Foundation of Korea (NRF) funded by the Ministry
   of Science, ICT and future Planning (No. 2014R1A2A2A01006008).
CR [Anonymous], NUTR LABELS OBESITY
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NR 30
TC 0
Z9 0
U1 1
U2 8
PU KOREAN SOC NURSING SCIENCE
PI SEOUL
PA KOREA SCIENCE & TECHNOL CTR, 635-4 YEOKSAM-DONG, KANGNAM-GU,, SEOUL,
   135-703, SOUTH KOREA
SN 2005-3673
EI 2093-758X
J9 J KOREAN ACAD NURS
JI J. Korean Acad. Nurs.
PD FEB
PY 2017
VL 47
IS 1
BP 133
EP 141
DI 10.4040/jkan.2017.47.1.133
PG 9
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA EP7HR
UT WOS:000397549400012
PM 28262661
DA 2025-06-11
ER

PT J
AU Gordijn, MS
   van Litsenburg, RR
   Gemke, RJBJ
   Bierings, MB
   Hoogerbrugge, PM
   van de Ven, PM
   Heijnen, CJ
   Kaspers, GJL
AF Gordijn, Maartje S.
   van Litsenburg, Raphaele R.
   Gemke, Reinoud J. B. J.
   Bierings, Marc B.
   Hoogerbrugge, Peter M.
   van de Ven, Peter M.
   Heijnen, Cobi J.
   Kaspers, Gertjan J. L.
TI Hypothalamic-pituitary-adrenal axis function in survivors of childhood
   acute lymphoblastic leukemia and healthy controls
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE HPA-axis; Cortisol awakening response; Dexamethasone suppression test;
   Acute lymphoblastic leukemia; Child
ID POSTTRAUMATIC-STRESS-DISORDER; QUALITY-OF-LIFE; MULTIDIMENSIONAL FATIGUE
   SCALE; CORTISOL AWAKENING RESPONSE; SLEEP HABITS QUESTIONNAIRE;
   LONG-TERM SURVIVORS; SALIVARY CORTISOL; METABOLIC SYNDROME;
   BREAST-CANCER; YOUNG-ADULTS
AB Of all malignancies in children, acute lymphoblastic leukemia (ALL) is the most common type. Since survival significantly improves over time, treatment-related side effects become increasingly important. Glucocorticoids play an important role in the treatment of ALL, but they may suppress the hypothalamic-pituitary-adrenal (HPA) axis. The duration of HPA axis suppression is not yet well defined. The present study aimed at assessing the function of the HPA axis by determining the cortisol awakening response (CAR) and the dexamethasone (DEX) suppression test in children that were treated for childhood ALL, compared to a healthy age and sex matched reference group. In addition, questionnaires regarding sleep, fatigue, depression and quality of life were completed by the children and their parents. Fourty-three survivors who finished their treatment for childhood ALL 37 (interquartile range 22-75) months before and 57 healthy controls were included. No differences in CAR were observed between ALL survivors and the reference group, but survivors of ALL had higher morning cortisol levels and an increased cortisol suppression in response to oral dexamethasone. Higher cortisol levels in childhood ALL survivors were associated with more fatigue and poorer quality of life. We conclude that the experience of a stressful life event in the past may have caused a long-term dysregulation of the HPA axis in childhood ALL survivors, as reflected in an increased cortisol production and an enhanced negative feedback mechanism. (C) 2012 Elsevier Ltd. All rights reserved.
C1 [Gordijn, Maartje S.; Kaspers, Gertjan J. L.] Vrije Univ Amsterdam Med Ctr, Dept Pediat, Div Oncol Hematol, NL-1007 MB Amsterdam, Netherlands.
   [Bierings, Marc B.] Univ Med Ctr Utrecht, Dept Pediat Hemato Oncol, Utrecht, Netherlands.
   [van de Ven, Peter M.] Vrije Univ Amsterdam Med Ctr, Dept Epidemiol & Biostat, NL-1007 MB Amsterdam, Netherlands.
   [Heijnen, Cobi J.] Univ Med Ctr Utrecht, Lab Neuroimmunol & Dev Origins Dis NIDOD, Utrecht, Netherlands.
   [Hoogerbrugge, Peter M.] Radboud Univ Nijmegen, Med Ctr, Dept Pediat Hemato Oncol, NL-6525 ED Nijmegen, Netherlands.
C3 Vrije Universiteit Amsterdam; VU UNIVERSITY MEDICAL CENTER; Utrecht
   University; Utrecht University Medical Center; Vrije Universiteit
   Amsterdam; VU UNIVERSITY MEDICAL CENTER; Utrecht University; Utrecht
   University Medical Center; Radboud University Nijmegen
RP Gordijn, MS (corresponding author), Vrije Univ Amsterdam Med Ctr, Dept Pediat, Div Oncol Hematol, POB 7057, NL-1007 MB Amsterdam, Netherlands.
EM ms.gordijn@vumc.nl
RI Hoogerbrugge, Peter/H-8049-2014; Bierings, Marc/HKM-5338-2023; Kaspers,
   Gertjan/ABC-5334-2020
OI Kaspers, Gertjan/0000-0001-7716-8475
FU Dutch Cancer Society
FX This study was financially supported by the Dutch Cancer Society.
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NR 74
TC 16
Z9 20
U1 0
U2 11
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD SEP
PY 2012
VL 37
IS 9
BP 1448
EP 1456
DI 10.1016/j.psyneuen.2012.01.014
PG 9
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA 991CJ
UT WOS:000307678800009
PM 22385687
DA 2025-06-11
ER

PT J
AU Abebe, EC
   Mengstie, MA
   Seid, MA
   Malik, T
   Dejenie, TA
AF Abebe, Endeshaw Chekol
   Mengstie, Misganaw Asmamaw
   Seid, Mohammed Abdu
   Malik, Tabarak
   Dejenie, Tadesse Asmamaw
TI The evolving roles of alarin in physiological and disease conditions,
   and its future potential clinical implications
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Review
DE alarin; the galanin family; neuropeptides; physiological role; clinical
   implications
ID GALANIN-LIKE PEPTIDE; SYMPATHETIC AFFERENT REFLEX; MTOR SIGNALING
   PATHWAY; STIMULATES FOOD-INTAKE; NEUROPEPTIDE-Y; BODY-WEIGHT; SUPEROXIDE
   ANIONS; NERVOUS-SYSTEM; ENERGY-BALANCE; CHRONIC STRESS
AB Alarin is a member of the galanin family of neuropeptides that is widely expressed in the central nervous system and peripheral tissues in humans and rodents. It was initially isolated fifteen years ago in ganglionic cells of human neuroblastoma. Subsequently, it was demonstrated to be broadly distributed in the blood vessels, skin, eyes, peripheral and central nervous systems, thymus, gastrointestinal tract, and endocrine organs of different species. Alarin is a 25 amino acid neuropeptide derived from the alternative splicing of the GALP gene, missing exon 3. It is found to be involved in several physiological functions that include feeding behavior, energy homeostasis, glucose homeostasis, body temperature, and reproduction. It has also vasoactive, anti-inflammatory, anti-edema, and antimicrobial activities. However, the physiological effects of alarin have not been fully elucidated and the receptors that mediate these effects are not currently known. Unearthing the novel biological effects of alarin and its unidentified receptors will therefore be a task in future biomedical research.In addition, alarin is involved in various disease conditions, such as metabolic syndrome, obesity, insulin resistance, type 2 diabetes, diabetic retinopathy, hypertension, cardiac fibrosis, polycystic ovarian syndrome, and depression. Thus, alarin may serve as a promising tool for future pharmacological treatment and diagnosis. But further research is awaited to confirm whether alarin has a protective or pathological role in these diseases. This article provides a comprehensive review on the evolving implications of alarin in a variety of physiological and disease conditions, and its future perspectives.
C1 [Abebe, Endeshaw Chekol; Mengstie, Misganaw Asmamaw] Debre Tabor Univ, Coll Hlth Sci, Dept Med Biochem, Debre Tabor, Ethiopia.
   [Seid, Mohammed Abdu] Debre Tabor Univ, Coll Hlth Sci, Dept Physiol, Debre Tabor, Ethiopia.
   [Malik, Tabarak; Dejenie, Tadesse Asmamaw] Univ Gondar, Coll Med & Hlth Sci, Dept Med Biochem, Gondar, Ethiopia.
C3 University of Gondar
RP Abebe, EC (corresponding author), Debre Tabor Univ, Coll Hlth Sci, Dept Med Biochem, Debre Tabor, Ethiopia.
EM endeshawchekole@gmail.com
RI Dejenie, Tadesse/AAA-4194-2021; Seid, Mohammed Abdu/ABM-9450-2022;
   Abebe, Endeshaw/AHE-4369-2022; Asmamaw, Misganaw/IAR-9902-2023; MALIK,
   TABARAK/M-3672-2014
OI Abdu Seid, Mohammed/0000-0002-3197-5332; Asmamaw Dejenie,
   Tadesse/0000-0002-2033-6113; MALIK, TABARAK/0000-0002-8332-7927; Chekol
   Abebe, Endeshaw/0000-0002-5035-6633
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NR 84
TC 6
Z9 6
U1 1
U2 8
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD SEP 29
PY 2022
VL 13
AR 1028982
DI 10.3389/fendo.2022.1028982
PG 16
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 5I7LH
UT WOS:000868533300001
PM 36246892
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Soreca, I
   Wallace, ML
   Frank, E
   Hasler, BP
   Levenson, JC
   Kupfer, DJ
AF Soreca, I.
   Wallace, M. L.
   Frank, E.
   Hasler, B. P.
   Levenson, J. C.
   Kupfer, D. J.
TI Sleep duration is associated with dyslipidemia in patients with bipolar
   disorder in clinical remission
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Bipolar disorder; Sleep; Cardiovascular risk; HDL
ID METABOLIC SYNDROME; CARDIOVASCULAR-DISEASE; RISK; DEPRESSION;
   DEPRIVATION; MORTALITY; RHYTHMS; QUALITY; MARKER; HEALTH
AB Background: The pathways to increased cardiovascular risk in bipolar disorder include health behaviors, psychosocial stress and long-term medication exposure. However, the evidence that the association between cardiovascular risk factors and bipolar disorder remains significant after controlling for these co-factors suggests that additional important risk factors have yet to be identified. Our hypothesis is that disturbances in the sleep-wake cycle are an important and under-recognized pathway through which affective disorders lead to increased cardiovascular risk.
   Methods: In patients with bipolar disorder type 1 in clinical remission, we: 1) explored whether sleep disturbance predicted the endorsement of NCEP ATP-III criteria for dyslipidemia, independent of other lifestyle factors and 2) tested the association between low HDL (NCEP-ATP III) and sleep duration measured with actigraphy over an eight-day period.
   Results: Median sleep duration is significantly associated with low HDL. The risk of having low HDL increases by 1.23 with every 30 minutes of reduced sleep time.
   Limitations: Since sleep patterns in patients with bipolar disorder are variable and irregular, it is possible that other sleep characteristics, not present during the span of our study, or the variability itself may be what drives the increased cardiovascular risk.
   Conclusions: Sleep characteristics of patients with bipolar disorder in clinical remission are associated with cardiovascular risk. More specifically, sleep duration was associated with low HDL. Clinicians should pay special attention to sleep hygiene in treating individuals with bipolar disorder, even when they are in clinical remission. (C) 2012 Elsevier B. V. All rights reserved.
C1 [Soreca, I.; Frank, E.; Hasler, B. P.; Levenson, J. C.; Kupfer, D. J.] Univ Pittsburgh, Sch Med, Dept Psychiat, Pittsburgh, PA 15260 USA.
   [Wallace, M. L.] Univ Pittsburgh, Dept Stat, Pittsburgh, PA 15260 USA.
   [Levenson, J. C.] Univ Pittsburgh, Dept Psychol, Pittsburgh, PA 15260 USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE); University
   of Pittsburgh; Pennsylvania Commonwealth System of Higher Education
   (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of
   Higher Education (PCSHE); University of Pittsburgh
RP Soreca, I (corresponding author), Western Psychiat Inst & Clin, BT Room 807A,3811 OHara St, Pittsburgh, PA 15213 USA.
EM sorecai@upmc.edu
RI Wallace, Meredith/LXV-0747-2024; Hasler, Brant/D-5989-2017; Levenson,
   Jessica/O-5448-2015
FU  [MH081003];  [DA027508-03]
FX This work was funded by MH081003 (DJK) and DA027508-03 (IS).
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NR 28
TC 22
Z9 23
U1 0
U2 10
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0165-0327
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD DEC 10
PY 2012
VL 141
IS 2-3
BP 484
EP 487
DI 10.1016/j.jad.2012.01.046
PG 4
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA 039IF
UT WOS:000311237700048
PM 22578889
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Bernal-Pacheco, O
   Román, GC
AF Bernal-Pacheco, Oscar
   Roman, Gustavo C.
TI Environmental vascular risk factors:: New perspectives for stroke
   prevention
SO JOURNAL OF THE NEUROLOGICAL SCIENCES
LA English
DT Article; Proceedings Paper
CT Meeting of the Environmental-Neurology-Club
CY FEB 07, 2007
CL Metz, FRANCE
SP French Soc Neurol, Univ Metz, Environm Neurol Res Grp, WFN, Environm Neurol Club
DE stroke; obesity; vascular risk factors; education; socioeconomic
   factors; sleep apnea; periodontal disease; diet
ID OBSTRUCTIVE SLEEP-APNEA; CORONARY-HEART-DISEASE; C-REACTIVE PROTEIN;
   SYSTOLIC BLOOD-PRESSURE; CARDIOVASCULAR-DISEASE; PERIODONTAL-DISEASE;
   METABOLIC SYNDROME; PHYSICAL-ACTIVITY; ISCHEMIC-STROKE; FOLLOW-UP
AB Despite intensive evaluation of acute stroke patients, perhaps only half of the attributable stroke risk is usually identified. In addition to traditional and non-traditional vascular risk factors-including most recently homocysteine, inflammation, and alterations of coagulation-a number of environmental risk factors for stroke have been identified in the last decade. In this update we review the following: lower education and poor socioeconomic status (probable surrogates for exposure to traditional high-risk behaviors such as smoking, poor nutrition, lack of prenatal control, absence of preventive medical and dental care, and non-compliance of treatment of conditions such as hypertension); depression, stress and affective disorders; obstructive sleep apnea; passive smoking and environmental pollution; infections, in particular periodontal diseases that increase C-reactive protein (CRP); raised body mass index (obesity); exercise, and diet. The possible role of high-fructose corn syrup in the epidemic of obesity in the USA is reviewed. Protective diets include higher consumption of fish, olive oil, grains, fruits and vegetables (Mediterranean diet), as well as probiotic bacteria in yogurt and dairy products. Careful attention should be given to the patient's environment looking for modifiable factors. The effects of clean environmental air and water, adequate diet and appropriate nutrition, healthy teeth, exercise, and refreshing sleep in the prevention of stroke and cardiovascular disease appear to be quite compelling. Although some of these modifiable risk factors lack evidence-based information, judicious clinical sense should be used to counteract the potentially damaging effects of adverse environmental vascular risk factors. (c) 2007 Elsevier B.V. All rights reserved.
C1 Univ Texas, Hlth Sci Ctr, San Antonio, TX 78249 USA.
   Vet Adm Hosp, San Antonio, TX USA.
   Cent Mil Hosp, Bogota, Colombia.
C3 University of Texas System; University of Texas Health Science Center at
   San Antonio; US Department of Veterans Affairs; Veterans Health
   Administration (VHA); Audie L. Murphy Memorial Veterans Hospital
RP Román, GC (corresponding author), Univ Texas, Hlth Sci Ctr, San Antonio, TX 78249 USA.
EM romang@uthscsa.edu
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NR 161
TC 40
Z9 43
U1 0
U2 17
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0022-510X
EI 1878-5883
J9 J NEUROL SCI
JI J. Neurol. Sci.
PD NOV 15
PY 2007
VL 262
IS 1-2
BP 60
EP 70
DI 10.1016/j.jns.2007.06.026
PG 11
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Neurosciences & Neurology
GA 221RL
UT WOS:000250244900010
PM 17655871
DA 2025-06-11
ER

PT J
AU Fu, JH
   Sun, HS
   Wang, Y
   Zheng, WQ
   Shi, ZY
   Wang, QJ
AF Fu, J. -h.
   Sun, H. -s.
   Wang, Y.
   Zheng, W. -q.
   Shi, Z. -y.
   Wang, Q. -j.
TI The Effects of a Fat- and Sugar-Enriched Diet and Chronic Stress on
   Nonalcoholic Fatty Liver Disease in Male Wistar Rats
SO DIGESTIVE DISEASES AND SCIENCES
LA English
DT Article
DE Nonalcoholic fatty liver disease; Fat- and sugar-enriched diet; Chronic
   stress; Synergetic effect
ID OXIDATIVE STRESS; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   STEATOHEPATITIS; MODEL; BETA
AB The pathogenesis of nonalcoholic fatty liver disease (NAFLD) is still under debate. The aim of this study was to investigate the effects of a long-term fat- and sugar-enriched diet (FSED) and chronic stress (CS) on NAFLD.
   Male Wistar rats were fed on either a standard diet or a FSED and given CS, a random electric foot shock (2 hr/morning and afternoon per day), or not for 12 weeks. After the experimental period, epididymal adipose tissue weight, sign of visceral obesity (VO), and hepatic index (HI) were measured. At sacrifice blood samples and liver were obtained. Histology of the liver was blindly determined by a pathologist.
   Histopathologically, moderate to severe steatosis, ballooning hepatocytes, and portal or lobules inflammation were observed in the FSED+CS group. However, mild to moderate steatosis with a few portal inflammation in the FSED group and mild steatosis or not with a few portal inflammation in the CS group were found correspondingly. In addition, more severe blood-fat disorder, high HI, fatty metabolic dysfunction, oxidative stress, high expressions of C-reactive protein mRNA and low expressions of peroxisome proliferator-activated receptor alpha mRNA in the liver were also revealed in the FSED+CS group. But, the degree of VO was not different between the FSED and FSED+CS groups.
   The observations strongly suggest that chronic stress can aggravate fat- and sugar-enriched diet-induced NAFLD from steatosis to steatohepatitis in male Wistar rats, although VO is not changed.
C1 [Fu, J. -h.; Sun, H. -s.; Wang, Y.; Zheng, W. -q.; Wang, Q. -j.] China Pharmaceut Univ, Dept Physiol, Nanjing 210009, Peoples R China.
   [Shi, Z. -y.] Southeast Univ, Dept Pathol, Nanjing, Peoples R China.
C3 China Pharmaceutical University; Southeast University - China
RP Wang, QJ (corresponding author), China Pharmaceut Univ, Dept Physiol, 24 Tong Jia Xiang, Nanjing 210009, Peoples R China.
EM fjhn.cpu@163.com
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NR 34
TC 26
Z9 31
U1 0
U2 11
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0163-2116
EI 1573-2568
J9 DIGEST DIS SCI
JI Dig. Dis. Sci.
PD AUG
PY 2010
VL 55
IS 8
BP 2227
EP 2236
DI 10.1007/s10620-009-1019-6
PG 10
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 617PV
UT WOS:000279294200014
PM 19847649
DA 2025-06-11
ER

PT J
AU Verstraeten, VLRM
   Caputo, S
   van Steensel, MAM
   Duband-Goulet, I
   Zinn-Justin, S
   Kamps, M
   Kuijpers, HJH
   Östlund, C
   Worman, HJ
   Briedé, JJ
   Le Dour, C
   Marcelis, CLM
   van Geel, M
   Steijlen, PM
   van den Wijngaard, A
   Ramaekers, FCS
   Broers, JLV
AF Verstraeten, Valerie L. R. M.
   Caputo, Sandrine
   van Steensel, Maurice A. M.
   Duband-Goulet, Isabelle
   Zinn-Justin, Sophie
   Kamps, Miriam
   Kuijpers, Helma J. H.
   Oestlund, Cecilia
   Worman, Howard J.
   Briede, Jacob J.
   Le Dour, Caroline
   Marcelis, Carlo L. M.
   van Geel, Michel
   Steijlen, Peter M.
   van den Wijngaard, Arthur
   Ramaekers, Frans C. S.
   Broers, Jos L. V.
TI The R439C mutation in LMNA causes lamin oligomerization and
   susceptibility to oxidative stress
SO JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
LA English
DT Article
DE FPLD; laminopathy; lipodystrophy; oxidative stress; oligomerization;
   disulphide bond; DNA; ROS; cysteine
ID FAMILIAL PARTIAL LIPODYSTROPHY; A-TYPE LAMINS; NUCLEAR-ENVELOPE;
   BUILDING-BLOCKS; A/C; PROTEINS; GENE; PRELAMIN; LAMINOPATHIES;
   FIBROBLASTS
AB Dunnigan-type familial partial lipodystrophy (FPLD) is a laminopathy characterized by an aberrant fat distribution and a metabolic syndrome for which oxidative stress has recently been suggested as one of the disease-causing mechanisms. In a family affected with FPLD, we identified a heterozygous missense mutation c.1315C>T in the LMNA gene leading to the p.R439C substitution. Cultured patient fibroblasts do not show any prelamin A accumulation and reveal honeycomb-like lamin A/C formations in a significant percentage of nuclei. The mutation affects a region in the C-terminal globular domain of lamins A and C, different from the FPLD-related hot spot. Here, the introduction of an extra cysteine allows for the formation of disulphide-mediated lamin A/C oligomers. This oligomerization affects the interaction properties of the C-terminal domain with DNA as shown by gel retardation assays and causes a DNA-interaction pattern that is distinct from the classical R482W FPLD mutant. Particularly, whereas the R482W mutation decreases the binding efficiency of the C-terminal domain to DNA, the R439C mutation increases it. Electron spin resonance spectroscopy studies show significantly higher levels of reactive oxygen species (ROS) upon induction of oxidative stress in R439C patient fibroblasts compared to healthy controls. This increased sensitivity to oxidative stress seems independent of the oligomerization and enhanced DNA binding typical for R439C, as both the R439C and R482W mutants show a similar and significant increase in ROS upon induction of oxidative stress by H2O2.
C1 [Verstraeten, Valerie L. R. M.; van Steensel, Maurice A. M.; Kamps, Miriam; van Geel, Michel; Steijlen, Peter M.] Univ Hosp Maastricht, Dept Dermatol, Maastricht, Netherlands.
   [Verstraeten, Valerie L. R. M.; van Steensel, Maurice A. M.; Kamps, Miriam; van Geel, Michel; Steijlen, Peter M.; Ramaekers, Frans C. S.; Broers, Jos L. V.] Univ Maastricht, Res Inst Growth & Dev, Maastricht, Netherlands.
   [Caputo, Sandrine; Zinn-Justin, Sophie] CEA, iBiTec S, Lab Biol Struct & Radiobiol, Gif Sur Yvette, France.
   [Caputo, Sandrine] CNRS, Inst Chim Subst Nat, Gif Sur Yvette, France.
   [Caputo, Sandrine] Ecole Polytech, Palaiseau, France.
   [Duband-Goulet, Isabelle] Univ Paris 06, CNRS, Inst Jacques Monod, UMR, F-75252 Paris 05, France.
   [Duband-Goulet, Isabelle] Univ Paris 07, CNRS, Inst Jacques Monod, UMR, F-75221 Paris 05, France.
   [Kamps, Miriam; Kuijpers, Helma J. H.; Ramaekers, Frans C. S.; Broers, Jos L. V.] Univ Maastricht, Dept Mol Cell Biol, Maastricht, Netherlands.
   [Oestlund, Cecilia; Worman, Howard J.] Columbia Univ, Coll Phys & Surg, Dept Med, New York, NY 10027 USA.
   [Oestlund, Cecilia; Worman, Howard J.] Columbia Univ, Coll Phys & Surg, Dept Anat & Cell Biol, New York, NY 10027 USA.
   [Briede, Jacob J.] Univ Maastricht, Fac Hlth Med & Life Sci, Dept Hlth Risk Anal & Toxicol, Maastricht, Netherlands.
   [Le Dour, Caroline] Fac Med Pierre & Marie Curie, INSERM, Paris, France.
   [Le Dour, Caroline] UPMC Univ Paris, Paris, France.
   [Marcelis, Carlo L. M.] Radboud Univ Nijmegen, Med Ctr, Dept Clin Genet, Nijmegen, Netherlands.
   [van den Wijngaard, Arthur] Univ Hosp Maastricht, Dept Clin Genet, Maastricht, Netherlands.
   [Ramaekers, Frans C. S.] Univ Maastricht, CARIM, Maastricht, Netherlands.
   [Broers, Jos L. V.] Eindhoven Univ Technol, Dept Biomed Engn Biomech & Tissue Engn, NL-5600 MB Eindhoven, Netherlands.
C3 Maastricht University; Maastricht University Medical Centre (MUMC);
   Maastricht University; Universite Paris Saclay; CEA; Centre National de
   la Recherche Scientifique (CNRS); Universite Paris Saclay; Institut
   Polytechnique de Paris; Ecole Polytechnique; Universite Paris Cite;
   Centre National de la Recherche Scientifique (CNRS); Sorbonne
   Universite; Universite Paris Cite; Centre National de la Recherche
   Scientifique (CNRS); Maastricht University; Columbia University;
   Columbia University; Maastricht University; Institut National de la
   Sante et de la Recherche Medicale (Inserm); Sorbonne Universite;
   Sorbonne Universite; Radboud University Nijmegen; Maastricht University;
   Maastricht University Medical Centre (MUMC); Maastricht University;
   Maastricht University Medical Centre (MUMC); Eindhoven University of
   Technology
RP Verstraeten, VLRM (corresponding author), Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Med, Cambridge, MA 02139 USA.
EM vverstraeten@rics.bwh.harvard.edu
RI Steijlen, Peter/X-2729-2019; Le Dour, Caroline/LIG-7650-2024; van
   Steensel, Maurice/V-3852-2019; Caputo, Sandrine/C-3860-2018; Marcelis,
   Carlo/L-4504-2015
OI Le Dour, Caroline/0000-0001-8647-3252; Caputo,
   Sandrine/0000-0001-5338-9388; van Steensel, Maurice/0000-0002-7507-2442;
   Marcelis, Carlo/0000-0001-7095-4641; Briede, Jacco/0000-0003-1405-5232
FU University Hospital Maastricht; Barrier Therapeutics; Netherlands
   Organization for Scientific Research (NWO) [901-28-134]
FX This work is supported by a research grant of the University Hospital
   Maastricht to V. L. R. M. V. M. A. M. v. S. is financially supported by
   Barrier Therapeutics and a grant from the University Hospital
   Maastricht. The authors acknowledge Yvette Hartsteen (Department of
   Health Risk Analysis & Toxicology, University of Maastricht, the
   Netherlands) for her help with the ESR spectroscopy, Dr. Michel B.
   Toledano (Laboratoire Stress Oxydants et Cancer, Service de Biologie
   Moleculaire Systemique, CEA, Gif-sur-Yvette, France) for his protocol on
   the assessment of disulphide-mediated complexes, Dr. Jean-Claude
   Courvalin (INSERM, Institut Jacques Monod, France) for kindly providing
   the antibody to lamin B1, Dr. E. B. Lane (University of Dundee, UK) for
   kindly providing the antibody to lamin B2, Dr. Chris Hutchinson (Durham
   University, UK) for kindly providing antibody Jol-2, Dr. Georg Krohne
   (University of Wuerzburg, Germany) for kindly providing antibody X67,
   Dr. Michael S. Sinensky (East Tennessee State University, USA) for
   kindly providing antibody alpha-PA and Dr. Jan Lammerding (Brigham and
   Women's Hospital/Harvard Medical School, Boston, USA) for critical
   reading of the manuscript and helpful discussions. The Netherlands
   Organization for Scientific Research (NWO, project 901-28-134) is
   acknowledged for financial support for microscopic equipment and imaging
   software.
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NR 40
TC 36
Z9 43
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1582-1838
EI 1582-4934
J9 J CELL MOL MED
JI J. Cell. Mol. Med.
PD MAY
PY 2009
VL 13
IS 5
BP 959
EP 971
DI 10.1111/j.1582-4934.2009.00690.x
PG 13
WC Cell Biology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Research & Experimental Medicine
GA 458AB
UT WOS:000266980300012
PM 19220582
OA Green Published
DA 2025-06-11
ER

PT J
AU de Azevedo, SC
   Feiten, JG
   Fleck, MP
   Caldieraro, MA
AF de Azevedo, Sofia Cid
   Feiten, Jacson Gabriel
   Fleck, Marcelo P.
   Caldieraro, Marco Antonio
TI The relevance of endoplasmic reticulum lumen and Anoctamin-8 for major
   depression: Results from a systems biology study
SO JOURNAL OF PSYCHIATRIC RESEARCH
LA English
DT Article
DE Major depressive disorder; Proteomics; Systems biology; Protein
   interaction networks; Gene ontologies
ID MYOCARDIAL-INFARCTION; NEUROTROPHIC FACTOR; METABOLIC SYNDROME; STRESS;
   PLASMA; IDENTIFICATION; EXPRESSION; PROTEINS; SERUM; LIPOPROTEIN(A)
AB Major depressive disorder (MDD) is a highly prevalent and debilitating disorder, yet its pathophysiology has not been fully elucidated. The aim of this study is to identify novel potential proteins and biological processes associated with MDD through a systems biology approach. Original articles involving the measurement of proteins in the blood of patients diagnosed with MDD were selected. Data on the differentially expressed proteins (DEPs) in each article were extracted and imported into R, and the pathfindR package was used to identify the main gene ontology terms involved. Data from the STRING database were combined with the DEPs identified in the original studies to create expanded networks of protein-protein interactions (PPIs). An R script was developed to obtain the five most reliable connections from each DEP and to create the networks, which were visualized through Cytoscape software. Out of 510 articles found, eight that contained all the values necessary for the analysis were selected, including 1112 adult patients with MDD and 864 controls. A total of 240 DEPs were identified, with the most significant gene ontology term being "endoplasmic reticulum lumen" (46 DEPs, p-value = 5.5x10-13). An extended PPI network was obtained, where Anoctamin-8 was the most central protein. Using systems biology contributed to the interpretation of data obtained in proteomic studies on MDD and expanded the findings of these studies. The combined use of these methodologies can provide new insights into the pathophysiology of psychiatric disorders, identifying novel biomarkers to improve diagnostic, prognostic, and treatment strategies in MDD.
C1 [de Azevedo, Sofia Cid; Feiten, Jacson Gabriel; Caldieraro, Marco Antonio] Fed Univ Rio Grande do Sul UFRGS, Hosp Clin Porto Alegre HCPA, Ctr Pesquisa Expt, Lab Mol Psychiat, Rua Ramiro Barcelos 2350, Porto Alegre, Brazil.
   [de Azevedo, Sofia Cid; Feiten, Jacson Gabriel; Fleck, Marcelo P.; Caldieraro, Marco Antonio] Fed Univ Rio Grande Do Sul UFRGS, Dept Psychiat, Postgrad Program Psychiat & Behav Sci, Rua Ramiro Barcelos 2400, Porto Alegre, RS, Brazil.
   [Fleck, Marcelo P.] Fed Univ Rio Grande do Sul UFRGS, Hosp Clin Porto Alegre HCPA, Dept Psychiat, Rua Ramiro Barcelos 2350, Porto Alegre, Brazil.
C3 Universidade Federal do Rio Grande do Sul; Hospital de Clinicas de Porto
   Alegre; Universidade Federal do Rio Grande do Sul; Universidade Federal
   do Rio Grande do Sul; Hospital de Clinicas de Porto Alegre
RP de Azevedo, SC (corresponding author), Hosp Clin Porto Alegre, Dept Psiquiatria, Rua Ramiro Barcelos 2350, BR-90035003 Porto Alegre, RS, Brazil.
EM scazevedo@hcpa.edu.br
RI Feiten, Jacson/AAD-3801-2021; Caldieraro, Marco/U-7356-2019; Fleck,
   Marcelo/B-6706-2009; Caldieraro, Marco Antonio/B-2294-2013
OI Cid de Azevedo, Sofia/0000-0001-7688-8956; Caldieraro, Marco
   Antonio/0000-0002-4355-9547
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NR 67
TC 0
Z9 0
U1 1
U2 1
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-3956
EI 1879-1379
J9 J PSYCHIATR RES
JI J. Psychiatr. Res.
PD FEB
PY 2025
VL 182
BP 329
EP 337
DI 10.1016/j.jpsychires.2025.01.039
EA JAN 2025
PG 9
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA T9N5M
UT WOS:001408188400001
PM 39848100
DA 2025-06-11
ER

PT J
AU Chang, J
   Hwang, SY
   Park, SK
   Kim, JH
   Kim, HJ
   Chae, SW
   Song, JJ
AF Chang, Jiwon
   Hwang, Soon Young
   Park, Su Kyoung
   Kim, Jin Hwan
   Kim, Hyung-Jong
   Chae, Sung-Won
   Song, Jae-Jun
TI Prevalence of Dizziness and Associated Factors in South Korea: A
   Cross-Sectional Survey From 2010 to 2012
SO JOURNAL OF EPIDEMIOLOGY
LA English
DT Article
DE dizziness; epidemiology; prevalence; risk factor
ID NUTRITION-EXAMINATION-SURVEY; PRACTICE COMMUNITY SAMPLE; OTITIS-MEDIA;
   VESTIBULAR FUNCTION; METABOLIC SYNDROME; NATIONAL-HEALTH; POPULATION;
   VERTIGO; EPIDEMIOLOGY; BALANCE
AB Background: Dizziness is one of the most common complaints in medicine and a frequent symptom among older people. Dizziness has a considerable impact on life quality and is associated with high economic costs. The purpose of this study was to evaluate the prevalence of dizziness in the general population and to describe its clinical characteristics and associated factors.
   Methods: The Korea National Health and Nutrition Examination Survey (KNHANES) is a cross-sectional survey of the civilian, non-institutionalized population of South Korea. We evaluated data for 12,653 participants (5,450 men and 7,203 women), aged 40 years and above, whom participated in the KNHANES between 2010 and 2012.
   Results: In the age group over 40 years old, the 1-year prevalence of dizziness was 20.10%. Dizziness was more prevalent among women (25.18%) than among men (14.57%; P < 0.001) and the prevalence rate increased with age (P < 0.001). In multivariable analysis, female sex, older age, serum triglyceride level, experience of depression, limited functional status owing to visual acuity impairment, limited physical performance, smoking, alcohol consumption, and perception of stress were independently associated with dizziness.
   Conclusions: In our study, the prevalence of dizziness in the general population was 20.10%. There was a stronger relationship between dizziness and physical performance, chronic diseases, and health behaviors compared to that with otologic diseases. Interventions for dizziness should be approached in a multifactorial manner and an understanding of various factors is necessary for the prevention and management of this condition.
C1 [Chang, Jiwon; Park, Su Kyoung; Kim, Jin Hwan; Kim, Hyung-Jong] Hallym Univ, Dept Otolaryngol Head & Neck Surg, Coll Med, Seoul, South Korea.
   [Hwang, Soon Young] Korea Univ, Dept Biostat, Coll Med, Seoul, South Korea.
   [Chae, Sung-Won; Song, Jae-Jun] Korea Univ, Dept Otolaryngol Head & Neck Surg, Coll Med, Seoul, South Korea.
C3 Hallym University; Korea University; Korea University Medicine (KU
   Medicine); Korea University; Korea University Medicine (KU Medicine)
RP Song, JJ (corresponding author), Korea Univ, Dept Otorhinolaryngol Head & Neck Surg, Guro Hosp, 148 Gurodong Ro, Seoul 152703, South Korea.
EM jjsong23@gmail.com
RI Chang, Jiwon/KDO-4300-2024
OI Hwang, Soon Young/0000-0001-7474-1803; Song,
   Jae-Jun/0000-0002-8488-9091; Chang, Jiwon/0000-0003-1660-1831
FU Basic Science Research Program through the National Research Foundation
   of Korea - Ministry of Education [2013R1A1A2A10004451]
FX This research was supported by the Basic Science Research Program
   through the National Research Foundation of Korea, funded by the
   Ministry of Education [grant number 2013R1A1A2A10004451].
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NR 37
TC 21
Z9 22
U1 0
U2 4
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0917-5040
J9 J EPIDEMIOL
JI J. Epidemiol.
PY 2018
VL 28
IS 4
BP 176
EP 184
DI 10.2188/jea.JE20160113
PG 9
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA GD5WB
UT WOS:000430576800004
PM 29151473
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Garcia-Rizo, C
   Kirkpatrick, B
   Fernandez-Egea, E
   Oliveira, C
   Bernardo, M
AF Garcia-Rizo, Clemente
   Kirkpatrick, Brian
   Fernandez-Egea, Emilio
   Oliveira, Cristina
   Bernardo, Miguel
TI Abnormal glycemic homeostasis at the onset of serious mental illnesses:
   A common pathway
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE Schizophrenia; Major depressive disorder; Bipolar disorder; Type 2
   diabetes mellitus; Mortality; Thrifty psychiatric phenotype
ID POSTTRAUMATIC-STRESS-DISORDER; IMPAIRED FASTING GLUCOSE;
   CORONARY-HEART-DISEASE; DRUG-NAIVE PATIENTS; NONAFFECTIVE PSYCHOSIS;
   METABOLIC SYNDROME; BIPOLAR DISORDER; IN-UTERO; SCHIZOPHRENIA; TOLERANCE
AB Objective: Patients with serious mental illnesses exhibit a reduced lifespan compared with the general population, a finding that can not solely rely on high suicide risk, low access to medical care and unhealthy lifestyle. The main causes of death are medical related pathologies such as type 2 diabetes mellitus and cardiovascular disease; however pharmacological treatment might play a role.
   Material and methods: We compared a two hour glucose load in naive patients at the onset of a serious mental illness (N = 102) (84 patients with a first episode of schizophrenia and related disorders, 6 with a first episode of bipolar I disorder and 12 with a first episode of major depression disorder) with another psychiatric diagnose, adjustment disorder (N = 17) and matched controls (N = 98).
   Results: Young patients with serious mental illness showed an increased two hour glucose load compared with adjustment disorder and the control group. Mean two hour glucose values [standard deviation] were: for schizophrenia and related disorders 106.51 mg/dL [+/- 32.0], for bipolar disorder 118.33 mg/dL [+/- 34.3], for major depressive disorder 107.42 mg/dL[+/- 34.5], for adjustment disorder 79.06 mg/dL[+/- 24.4] and for the control group 82.11 mg/dL [+/- 23.3] (p < 0.001).
   Conclusions: Our results reflect an abnormal metabolic pathway at the onset of the disease before any pharmacological treatment or other confounding factors might have taken place. Our results suggest a similar glycemic pathway in serious mental illnesses and the subsequent need of primary and secondary prevention strategies. (C) 2016 Elsevier Ltd. All rights reserved.
C1 [Garcia-Rizo, Clemente; Oliveira, Cristina; Bernardo, Miguel] Hosp Clin Barcelona, Schizophrenia Unit, Neurosci Inst, Villarroel 170, E-08036 Barcelona, Spain.
   [Garcia-Rizo, Clemente; Bernardo, Miguel] Inst Biomed Res Agusti Pi & Sunyer IDIBAPS, Barcelona, Spain.
   [Garcia-Rizo, Clemente; Fernandez-Egea, Emilio; Bernardo, Miguel] Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain.
   [Kirkpatrick, Brian] Univ Nevada, Sch Med, Dept Psychiat & Behav Sci, Reno, NV 89557 USA.
   [Fernandez-Egea, Emilio] Univ Cambridge, Addenbrookes Hosp, Dept Psychiat, Cambridge CB2 0QQ, England.
   [Fernandez-Egea, Emilio] Cambridgeshire & Peterborough NHS Fdn, Huntingdon PE29 3RJ, England.
   [Bernardo, Miguel] Univ Barcelona, Dept Psychiat & Clin Psychobiol, Barcelona, Spain.
C3 University of Barcelona; Hospital Clinic de Barcelona; University of
   Barcelona; Hospital Clinic de Barcelona; IDIBAPS; CIBER - Centro de
   Investigacion Biomedica en Red; CIBERSAM; Nevada System of Higher
   Education (NSHE); University of Nevada Reno; Cambridge University
   Hospitals NHS Foundation Trust; Addenbrooke's Hospital; University of
   Cambridge; University of Barcelona
RP Garcia-Rizo, C (corresponding author), Hosp Clin Barcelona, Schizophrenia Unit, Villarroel 170, E-08036 Barcelona, Spain.
EM cgarcia3@clinic.ub.es
RI Bernardo, Miquel/P-3049-2015; garcia-rizo, clemente/C-5520-2019
OI Bernardo, Miquel/0000-0001-8748-6717; garcia-rizo,
   clemente/0000-0002-4855-1608; Fernandez-Egea, Emilio/0000-0003-4128-8955
FU National Institute of Diabetes and Digestive and Kidney Diseases [RO1
   DK069265]; NARSAD Instituto de Salud Carlos III; FEDER; Centro de
   Investigation Biomedica en Red de salud Mental, CIBERSAM; Government of
   Catalonia; Comissionat per Universitats i Recerca del Department
   d'Innovacio, Universitats i Empresa (DIUE) [2014SGR441]; Agencia de
   Gestio d'Ajuts Universitaris i de Recerca [FI-DGR-2013]; Esther
   Koplowitz Center-Barcelona
FX Funding for this study was provided by grant RO1 DK069265 - National
   Institute of Diabetes and Digestive and Kidney Diseases (Dr.
   Kirkpatrick), NARSAD (Dr. Fernandez-Egea) Instituto de Salud Carlos III,
   FEDER, Centro de Investigation Biomedica en Red de salud Mental,
   CIBERSAM, Government of Catalonia, Comissionat per Universitats i
   Recerca del Department d'Innovacio, Universitats i Empresa (DIUE)
   (2014SGR441), FI-DGR-2013Contract of the Agencia de Gestio d'Ajuts
   Universitaris i de Recerca, and by Esther Koplowitz Center-Barcelona
   (Dr. Bernardo).
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NR 57
TC 53
Z9 54
U1 0
U2 10
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD MAY
PY 2016
VL 67
BP 70
EP 75
DI 10.1016/j.psyneuen.2016.02.001
PG 6
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA DK0LC
UT WOS:000374603300008
PM 26878465
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Beattie, MC
   Adekola, L
   Papadopoulos, V
   Chen, H
   Zirkin, BR
AF Beattie, M. C.
   Adekola, L.
   Papadopoulos, V.
   Chen, H.
   Zirkin, B. R.
TI Leydig cell aging and hypogonadism
SO EXPERIMENTAL GERONTOLOGY
LA English
DT Article
DE Aging; Testosterone; Hypogonadism; TSPO
ID BROWN-NORWAY RAT; MICROSOMAL CYTOCHROME-P-450 ENZYMES; OXYGEN-MEDIATED
   DAMAGE; REGULATORY PROTEIN STAR; TESTOSTERONE PRODUCTION; CHOLESTEROL
   TRANSPORT; ANDROGEN DEFICIENCY; OXIDATIVE STRESS; MEN; STEROIDOGENESIS
AB Leydig cell testosterone (T) production is reduced with age, resulting in reduced serum T levels (hypogonadism). A number of cellular changes have been identified in the steroidogenic pathway of aged Leydig cells that are associated with reduced T formation, including reductions in luteinizing hormone (LH)-stimulated cAMP production, the cholesterol transport proteins steroidogenic acute regulatory (STAR) protein and translocator protein (TSPO), and downstream steroidogenic enzymes of the mitochondria and smooth endoplasmic reticulum. Many of the changes in steroid formation that characterize aged Leydig cells can be elicited by the experimental alteration of the redox environment of young cells, suggesting that changes in the intracellular redox balance may cause reduced T production. Hypogonadism is estimated to affect about 5 million American men, including both aged and young. This condition has been linked to mood changes, worsening cognition, fatigue, depression, decreased lean body mass, reduced bone mineral density, increased visceral fat, metabolic syndrome, decreased libido, and sexual dysfunction. Exogenous T administration is now used widely to elevate serum T levels in hypogonadal men and thus to treat symptoms of hypogonadism. However, recent evidence suggests that men who take exogenous T may face increased risk of stroke, heart attack, and prostate tumorigenesis. Moreover, it is well established that administered T can have suppressive effects on LH, resulting in lower Leydig cell T production, reduced intratesticular T concentration, and reduced spermatogenesis. This makes exogenous T administration inappropriate for men who wish to father children. There are promising new approaches to increase serum T by directly stimulating Leydig cell T production rather than by exogenous T therapy, thus potentially avoiding some of its negative consequences. (C) 2015 Elsevier Inc. All rights reserved.
C1 [Beattie, M. C.; Adekola, L.; Chen, H.; Zirkin, B. R.] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Biochem & Mol Biol, Baltimore, MD 21287 USA.
   [Papadopoulos, V.] McGill Univ, Ctr Hlth, Res Inst, Montreal, PQ, Canada.
   [Papadopoulos, V.] McGill Univ, Dept Med, Montreal, PQ, Canada.
   [Papadopoulos, V.] McGill Univ, Dept Biochem & Pharmacol, Montreal, PQ, Canada.
   [Papadopoulos, V.] McGill Univ, Dept Therapeut, Montreal, PQ, Canada.
C3 Johns Hopkins University; Johns Hopkins Bloomberg School of Public
   Health; McGill University; McGill University; McGill University; McGill
   University
RP Zirkin, BR (corresponding author), Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Biochem & Mol Biol, Baltimore, MD 21287 USA.
EM brzirkin@jhu.edu
RI Papadopoulos, Vassilios/AAI-2613-2019
OI Papadopoulos, Vassilios/0000-0002-1183-8568
FU National Institutes of Health [R37 AG021092, R03 AG026721]; Canadian
   Institutes of Health Research (CIHR) [MOP125983]; Canada Research Chair
   in Biochemical Pharmacology
FX This work was supported over the years by grants from the National
   Institutes of Health (R37 AG021092, R03 AG026721), the Canadian
   Institutes of Health Research (CIHR MOP125983), and a Canada Research
   Chair in Biochemical Pharmacology.
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NR 74
TC 94
Z9 110
U1 1
U2 32
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0531-5565
EI 1873-6815
J9 EXP GERONTOL
JI Exp. Gerontol.
PD AUG
PY 2015
VL 68
BP 87
EP 91
DI 10.1016/j.exger.2015.02.014
PG 5
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA CJ9PQ
UT WOS:000355835100016
PM 25700847
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Monserrat-Mesquida, M
   Quetglas-Llabrés, M
   Abbate, M
   Montemayor, S
   Mascaró, CM
   Casares, M
   Tejada, S
   Abete, I
   Zulet, MA
   Tur, JA
   Martínez, JA
   Sureda, A
AF Monserrat-Mesquida, Margalida
   Quetglas-Llabres, Magdalena
   Abbate, Manuela
   Montemayor, Sofia
   Mascaro, Catalina M.
   Casares, Miguel
   Tejada, Silvia
   Abete, Itziar
   Angeles Zulet, Maria
   Tur, Josep A.
   Alfredo Martinez, J.
   Sureda, Antoni
TI Oxidative Stress and Pro-Inflammatory Status in Patients with
   Non-Alcoholic Fatty Liver Disease
SO ANTIOXIDANTS
LA English
DT Article
DE nonalcoholic fatty liver disease (NAFLD); oxidative stress;
   inflammation; cytokine; steatosis; liver
ID GROWTH-FACTOR 21; METABOLIC SYNDROME; NONINVASIVE DIAGNOSIS;
   INSULIN-RESISTANCE; XANTHINE-OXIDASE; ER STRESS; FGF21; LIPOTOXICITY;
   PROGRESSION; MARKERS
AB Background: Nonalcoholic fatty liver disease (NAFLD) is characterized by excessive fat accumulation, especially triglycerides, in hepatocytes. If the pathology is not properly treated, it can progress to nonalcoholic steatohepatitis (NASH) and continue to fibrosis, cirrhosis or hepatocarcinoma. Objective: The aim of the current research was to identify the plasma biomarkers of liver damage, oxidative stress and inflammation that facilitate the early diagnosis of the disease and control its progression. Methods: Antioxidant and inflammatory biomarkers were measured in the plasma of patients diagnosed with NAFLD (n= 100 adults; 40-60 years old) living in the Balearic Islands, Spain. Patients were classified according to the intrahepatic fat content (IFC) measured by magnetic resonance imaging (MRI). Results: Circulating glucose, glycosylated haemoglobin, triglycerides, low-density lipoprotein-cholesterol, aspartate aminotransferase and alanine aminotransferase were higher in patients with an IFC >= 2 of NAFLD in comparison to patients with an IFC of 0 and 1. The plasma levels of catalase, irisin, interleukin-6, malondialdehyde, and cytokeratin 18 were higher in stage >= 2 subjects, whereas the resolvin D1 levels were lower. No differences were observed in xanthine oxidase, myeloperoxidase, protein carbonyl and fibroblast growth factor 21 depending on liver status. Conclusion: The current available data show that the severity of NAFLD is associated with an increase in oxidative stress and proinflammatory status. It may be also useful as diagnostic purpose in clinical practice.
C1 [Monserrat-Mesquida, Margalida; Quetglas-Llabres, Magdalena; Abbate, Manuela; Montemayor, Sofia; Mascaro, Catalina M.; Tejada, Silvia; Tur, Josep A.; Sureda, Antoni] Univ Balearic Isl, Res Grp Community Nutr & Oxidat Stress, Palma De Mallorca 07122, Spain.
   [Monserrat-Mesquida, Margalida; Quetglas-Llabres, Magdalena; Abbate, Manuela; Montemayor, Sofia; Mascaro, Catalina M.; Tejada, Silvia; Tur, Josep A.; Sureda, Antoni] Hlth Res Inst Balearic Isl IdISBa, Palma De Mallorca 07122, Spain.
   [Monserrat-Mesquida, Margalida; Tejada, Silvia; Abete, Itziar; Angeles Zulet, Maria; Tur, Josep A.; Alfredo Martinez, J.; Sureda, Antoni] Inst Salud Carlos III ISCIII, CIBER Fisiopatol Obesidad & Nutr CIBEROBN, Madrid 28029, Spain.
   [Monserrat-Mesquida, Margalida; Quetglas-Llabres, Magdalena; Abbate, Manuela; Montemayor, Sofia; Mascaro, Catalina M.; Tejada, Silvia; Tur, Josep A.; Sureda, Antoni] Hlth Res Inst Balearic Isl IdISBa, Palma De Mallorca 07120, Spain.
   [Casares, Miguel] Red Asistencial Juaneda, Radiodiag Serv, Palma De Mallorca 07011, Spain.
   [Tejada, Silvia] Univ Balearic Isl, Lab Neurophysiol, Palma De Mallorca 07122, Spain.
   [Abete, Itziar; Angeles Zulet, Maria; Alfredo Martinez, J.] Univ Navarra, Ctr Nutr Res, Dept Nutr Food Sci & Physiol, Pamplona 31008, Spain.
   [Alfredo Martinez, J.] CEI UAM CSIC, IMDEA Food, Cardiomet Precis Nutr Program, Madrid 28049, Spain.
C3 Universitat de les Illes Balears; Institut Investigacio Sanitaria Illes
   Balears (IdISBa); CIBER - Centro de Investigacion Biomedica en Red;
   CIBEROBN; Institut Investigacio Sanitaria Illes Balears (IdISBa);
   Universitat de les Illes Balears; University of Navarra; Consejo
   Superior de Investigaciones Cientificas (CSIC); IMDEA Food Institute
RP Tur, JA (corresponding author), Univ Balearic Isl, Res Grp Community Nutr & Oxidat Stress, Palma De Mallorca 07122, Spain.; Tur, JA (corresponding author), Hlth Res Inst Balearic Isl IdISBa, Palma De Mallorca 07122, Spain.; Tur, JA (corresponding author), Inst Salud Carlos III ISCIII, CIBER Fisiopatol Obesidad & Nutr CIBEROBN, Madrid 28029, Spain.; Tur, JA (corresponding author), Hlth Res Inst Balearic Isl IdISBa, Palma De Mallorca 07120, Spain.
EM margalida.monserrat@uib.es; m.quetglas@uib.es; manuela.abbate@uib.es;
   sofiamf16@gmail.com; catalinamaria95@hotmail.es;
   casaresmiguel@gmail.com; silvia.tejada@uib.es; iabetego@unay.es;
   mazulet@unay.es; pep.tur@uib.es; jalfredo.martinez@imdea.org;
   antoni.sureda@uib.es
RI Tur, Josep/AAE-5748-2020; Martínez, J./K-8709-2014; Sureda,
   Antoni/N-9588-2019; Tejada, Silvia/L-7297-2014; Mesquida,
   Margalida/AAB-4773-2019; Quetglas Llabrés, Maria/AAA-4412-2019; Abbate,
   Manuela/HCI-8844-2022; Zulet, M. Angeles/H-1317-2017; Abete,
   Itziar/H-4827-2017; Tur, Josep/F-5576-2014
OI Abbate, Manuela/0000-0001-9905-2414; Zulet, M.
   Angeles/0000-0002-3926-0892; Abete, Itziar/0000-0002-6475-5387;
   Monserrat Mesquida, Margalida/0000-0002-8856-135X; Mascaro Bestard,
   Catalina Maria/0000-0002-8235-2768; , Antoni/0000-0001-8656-6838; Tur,
   Josep/0000-0002-6940-0761
FU Fundacio La Marato TV3 (Spain) project [201630.10]; Instituto de Salud
   Carlos III through the Fondo de Investigacion para la Salud [PI14/00636,
   PI17/01827, CB12/03/30038, OBN18PI03]; Health Department of the
   Government of Navarra [61/2015]; European Regional Development Fund
   [35/2011, 23/2012]; EU-COST Action [CA16112]; SOIB Program for Qualified
   Young People; FPU PhD Grant from the Spanish Ministry of Education;
   IDISBA Grants
FX Fundacio La Marato TV3 (Spain) project ref. 201630.10. Instituto de
   Salud Carlos III through the Fondo de Investigacion para la Salud
   (Projects PI14/00636 and PI17/01827, CIBEROBN CB12/03/30038, and
   Proyecto Intramural CIBER OBN18PI03), Health Department of the
   Government of Navarra (61/2015), and Grant of support to research groups
   no. 35/2011 and 23/2012 (Balearic Islands Gov.), which are cofunded by
   the European Regional Development Fund. Other funding received: EU-COST
   Action CA16112, and IDISBA Grants (FOLIUM, PRIMUS, SYNERGIA, and
   LIBERI). M.Q.-LL. was granted by SOIB Program for Qualified Young
   People. C.M.M. received an FPU PhD Grant from the Spanish Ministry of
   Education. The funding sponsors had no role in the design of the study,
   in the collection, analyses, or interpretation of the data; in the
   writing of the manuscript, or in the decision to publish the results.
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NR 83
TC 71
Z9 73
U1 0
U2 14
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD AUG
PY 2020
VL 9
IS 8
AR 759
DI 10.3390/antiox9080759
PG 15
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA NH7FD
UT WOS:000564831000001
PM 32824349
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Ohno, T
   Shimizu, M
   Shirakami, Y
   Miyazaki, T
   Ideta, T
   Kochi, T
   Kubota, M
   Sakai, H
   Tanaka, T
   Moriwaki, H
AF Ohno, Tomohiko
   Shimizu, Masahito
   Shirakami, Yohei
   Miyazaki, Tsuneyuki
   Ideta, Takayasu
   Kochi, Takahiro
   Kubota, Masaya
   Sakai, Hiroyasu
   Tanaka, Takuji
   Moriwaki, Hisataka
TI Preventive effects of astaxanthin on diethylnitrosamine-induced liver
   tumorigenesis in C57/BL/KsJ-db/db obese mice
SO HEPATOLOGY RESEARCH
LA English
DT Article
DE adiponectin; astaxanthin; liver tumorigenesis; obesity; oxidative stress
ID DIABETIC C57BL/KSJ-DB/DB MICE; COLONIC PRENEOPLASTIC LESIONS; AMINO-ACID
   SUPPLEMENTATION; NONALCOHOLIC STEATOHEPATITIS; HEPATOCELLULAR-CARCINOMA;
   OXIDATIVE STRESS; INFLAMMATORY CYTOKINES; METABOLIC SYNDROME; LEPTIN
   RECEPTORS; CANCER
AB AimObesity and its related metabolic abnormalities, including oxidative stress and adipokine imbalance, are involved in liver carcinogenesis. The aim of the present study was to examine the effects of astaxanthin, a powerful biological antioxidant, on the development of diethylnitrosamine (DEN)-induced liver tumorigenesis in C57BL/KsJ-db/db (db/db) obese mice.
   MethodsMale db/db mice were given a single i.p. injection of DEN (25mg/kg bodyweight) at 2weeks of age, and, subsequently, from 4weeks of age, they were fed a diet containing 200p.p.m. astaxanthin throughout the experiment.
   ResultsTwenty weeks of astaxanthin administration significantly inhibited the development of hepatocellular neoplasms (liver cell adenoma and hepatocellular carcinoma) and the hepatic expression of cyclin D1 mRNA compared with the basal diet group in DEN-treated db/db mice. Astaxanthin administration in DEN-treated experimental mice markedly reduced the derivatives of reactive oxygen metabolites/biological antioxidant potential ratio, which is a serum marker of oxidative stress, while increasing the mRNA expression of the antioxidant enzymes superoxide dismutase 2 and glutathione peroxidase 1 in the liver and white adipose tissue. The serum levels of adiponectin increased after astaxanthin administration in these mice.
   ConclusionDietary astaxanthin prevented the development of liver tumorigenesis in obese mice by improving oxidative stress and ameliorating serum adiponectin level. Therefore, astaxanthin may be useful in the chemoprevention of liver tumorigenesis in obese individuals.
C1 [Ohno, Tomohiko; Shimizu, Masahito; Shirakami, Yohei; Miyazaki, Tsuneyuki; Ideta, Takayasu; Kochi, Takahiro; Kubota, Masaya; Sakai, Hiroyasu; Moriwaki, Hisataka] Gifu Univ, Grad Sch Med, Dept Gastroenterol Internal Med, 1-1 Yanagido, Gifu, Gifu 5011194, Japan.
   [Tanaka, Takuji] Gifu Univ, Grad Sch Med, Dept Tumor Pathol, 1-1 Yanagido, Gifu, Gifu 5011194, Japan.
C3 Gifu University; Gifu University
RP Shirakami, Y (corresponding author), Gifu Univ, Grad Sch Med, Dept Informat Clin Med Gastroenterol, 1-1 Yanagido, Gifu, Gifu 5011194, Japan.
EM ys2443@gifu-u.ac.jp
FU Ministry of Education, Science, Sports and Culture of Japan [22790638,
   25460988, 26860498]; Ministry of Health, Labor and Welfare of Japan;
   Takeda Science Foundation; Grants-in-Aid for Scientific Research
   [15K19320, 26860498] Funding Source: KAKEN
FX THIS WORK WAS supported in part by Grants-in-Aid from the Ministry of
   Education, Science, Sports and Culture of Japan (no. 22790638, 25460988,
   and 26860498), a Grant-in-Aid for the 3rd Term Comprehensive 10-Year
   Strategy for Cancer Control from the Ministry of Health, Labor and
   Welfare of Japan, and the Takeda Science Foundation.
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NR 44
TC 21
Z9 22
U1 1
U2 25
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1386-6346
EI 1872-034X
J9 HEPATOL RES
JI Hepatol. Res.
PD MAR
PY 2016
VL 46
IS 3
BP E201
EP E209
DI 10.1111/hepr.12550
PG 9
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA DI7QM
UT WOS:000373696600023
PM 26147624
OA Bronze
DA 2025-06-11
ER

PT J
AU Nangaku, M
   Izuhara, Y
   Usuda, N
   Inagi, R
   Shibata, T
   Sugiyama, S
   Kurokawa, K
   de Strihou, CVY
   Miyata, T
AF Nangaku, M
   Izuhara, Y
   Usuda, N
   Inagi, R
   Shibata, T
   Sugiyama, S
   Kurokawa, K
   de Strihou, CVY
   Miyata, T
TI In a type 2 diabetic nephropathy rat model, the improvement of obesity
   by a low calorie diet reduces oxidative/carbonyl stress and prevents
   diabetic nephropathy
SO NEPHROLOGY DIALYSIS TRANSPLANTATION
LA English
DT Article
DE advanced glycation end product; multiple risk factor intervention;
   pentosidine; proteinuria; renoprotection
ID GLYCATION END-PRODUCTS; CARBONYL STRESS; METABOLIC SYNDROME; RENAL
   DAMAGE; CARDIOVASCULAR-DISEASE; GLOMERULAR-LESIONS; FATTY RATS;
   PENTOSIDINE; INJURY; ACCUMULATION
AB Background. The present study has been undertaken to unravel the critical factors involved in the progression of diabetic nephropathy ( DN).
   Methods. A unique type 2 diabetic rat model with a wide range of metabolic derangements and hypertension has been utilized, the spontaneously hypertensive/NIH-corpulent rat SHR/NDmcr-cp(cp/cp). It develops histologically evident glomerular injury and tubulointerstitial damage, including mesangial activation, podocyte injury, and inflammatory cell infiltration in the tubulointerstitium.
   Results. A low calorie diet for 22 weeks significantly improves obesity, proteinuria and renal morphological alterations. The correction of renal injury is independent of blood pressure control. Obesity correction, although partial, normalizes the renal content of pentosidine taken as a marker of oxidative stress and advanced glycation end products ( AGEs). This occurs despite the fact that, in this model, improvement of glucose control and hyperlipidaemia is limited. Proteinuria and body weight are highly correlated with renal pentosidine content, while proteinuria and body weight are also correlated with each other. Diabetic renal injury is thus inhibited by a low calorie diet with an attendant reduction of oxidative stress and AGE formation, despite sustained hypertension.
   Conclusion. The present findings suggest a direct role of obesity in the generation of a localized oxidative stress and AGE formation, directly responsible for DN.
C1 Tokai Univ, Sch Med, Inst Med Sci, Isehara, Kanagawa 2591193, Japan.
   Tokai Univ, Sch Med, Div Nephrol Hypertens & Metab, Isehara, Kanagawa 2591193, Japan.
   Univ Tokyo, Sch Med, Div Nephrol & Endocrinol, Tokyo 113, Japan.
   Tokai Univ, Sch Med, Dept Med Educ & Informat, Isehara, Kanagawa 2591193, Japan.
   Univ Catholique Louvain, Serv Nephrol, B-1200 Brussels, Belgium.
C3 Tokai University; Tokai University; University of Tokyo; Tokai
   University; Universite Catholique Louvain
RP Tokai Univ, Sch Med, Inst Med Sci, Isehara, Kanagawa 2591193, Japan.
EM t-miyata@is.icc.u-tokai.ac.jp
RI Nangaku, Masaomi/A-5300-2010; Miyata, Toshio/A-4872-2010
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NR 39
TC 61
Z9 61
U1 0
U2 3
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0931-0509
EI 1460-2385
J9 NEPHROL DIAL TRANSPL
JI Nephrol. Dial. Transplant.
PD DEC
PY 2005
VL 20
IS 12
BP 2661
EP 2669
DI 10.1093/ndt/gfi096
PG 9
WC Transplantation; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Transplantation; Urology & Nephrology
GA 985FH
UT WOS:000233361800015
PM 16188903
OA Bronze
DA 2025-06-11
ER

PT J
AU Quines, CB
   Rosa, SG
   Da Rocha, JT
   Gai, BM
   Bortolatto, CF
   Duarte, MMMF
   Nogueira, CW
AF Quines, Caroline B.
   Rosa, Suzan G.
   Da Rocha, Juliana T.
   Gai, Bibiana M.
   Bortolatto, Cristiani F.
   Duarte, Marta Maria M. F.
   Nogueira, Cristina W.
TI Monosodium glutamate, a food additive, induces depressive-like and
   anxiogenic-like behaviors in young Rats
SO LIFE SCIENCES
LA English
DT Article
DE Monosodium glutamate; Serotonin; HPA axis; Anxiogenic-like behavior;
   Depressive-like behavior
ID METABOLIC SYNDROME; MAJOR DEPRESSION; MESSENGER-RNA; OBESE RATS; BRAIN;
   STRESS; MICE; EXPRESSION; CATECHOLAMINE; HYPOTHALAMUS
AB Monosodium glutamate (MSG) has been the target of research due to its toxicological effects.
   Aims: We investigated the depressive- and anxiogenic-like behaviors in rats exposed to neonatal subcutaneous injection of MSG. The involvement of the serotonergic system, by measuring [H-3] serotonin (5-HT) uptake in cerebral cortices, and the hypothalamic pituitary adrenal (HPA) axis, by determining serum adrenocorticotropic hormone (ACTH) and corticosterone levels, was also examined.
   Materials and methods: Male and female newborn Wistar rats were divided into control and MSG groups, which received, respectively, a daily subcutaneous injection of saline (0.9%) or MSG (4 g/kg/day) from the 1st to 5th postnatal day. The behavioral tests [spontaneous locomotor activity, contextual fear conditioning, and forced swimming test (FST)] were performed from the 60th to 64th postnatal day. MSG-treated animals showed alteration in the spontaneous locomotor activity, an increase in the number of fecal pellets and the number of animal's vocalizations and urine occurrence, and a decrease in the grooming time.
   Key findings: The MSG exposure increased the immobility time in the FST and the freezing reaction in the contextual fear conditioning. Additionally, MSG treatment increased the [H-3]5-HT uptake in the cerebral cortices of rats and induced a deregulation of HPA axis function (by increasing serum ACTH and corticosterone levels).
   Significance: In conclusion MSG-treated rats are more susceptible to develop anxiogenic- and depressive-like behaviors, which could be related to a dysfunction in the serotonergic system. (C) 2014 Elsevier Inc. All rights reserved.
C1 [Quines, Caroline B.; Rosa, Suzan G.; Da Rocha, Juliana T.; Gai, Bibiana M.; Bortolatto, Cristiani F.; Nogueira, Cristina W.] Univ Fed Santa Maria, Ctr Ciencias Nat & Exatas, Lab Sintese Reatividade & Avaliacao Farmacol & To, BR-97105900 Santa Maria, RS, Brazil.
   [Duarte, Marta Maria M. F.] Univ Luterana Brasil, Dept Ciencias Saude, Santa Maria, RS, Brazil.
C3 Universidade Federal de Santa Maria (UFSM); Universidade Luterana do
   Brasil
RP Nogueira, CW (corresponding author), Univ Fed Santa Maria, Ctr Ciencias Nat & Exatas, Dept Quim, BR-97105900 Santa Maria, RS, Brazil.
EM criswn@quimica.ufsm.br
RI Nogueira, Cristina/H-1581-2012; Rosa, Suzan/F-6756-2018; Bortolatto,
   Cristiani/E-3022-2015; Gai, Bibiana/G-5332-2015
OI Bortolatto, Cristiani/0000-0002-9509-4446; Nogueira, Cristina
   W./0000-0003-2950-3632; Rosa, Suzan/0000-0002-1832-982X
FU Universidade Federal de Santa Maria (UFSM); Coordenacao de
   Aperfeicoamento de Pessoal de Nivel Superior (CAPES); Conselho Nacional
   de Desenvolvimento Cientifico e Tecnologico (CNPq) [302384/2010-3];
   Fundacao de Amparo a Pesquisa do Estado do Rio Grande do Sul
   (FAPERGS-CNPq/PRONEX) [10/0005-41]; FAPERGS r [10/0711-6]
FX The financial support by the Universidade Federal de Santa Maria (UFSM),
   Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES),
   Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
   grant #302384/2010-3, and Fundacao de Amparo a Pesquisa do Estado do Rio
   Grande do Sul (FAPERGS-CNPq/PRONEX) research grant #10/0005-41 and
   FAPERGS research grant #10/0711-6 is gratefully acknowledged. C.W.N. is
   a recipient of the CNPq fellowship. J.T.R. is a recipient of the
   FAPERGS/CAPES fellowship SPI Process #2793-25.51/12-4.
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NR 41
TC 58
Z9 64
U1 0
U2 31
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0024-3205
EI 1879-0631
J9 LIFE SCI
JI Life Sci.
PD JUN 27
PY 2014
VL 107
IS 1-2
BP 27
EP 31
DI 10.1016/j.lfs.2014.04.032
PG 5
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA AJ7IP
UT WOS:000337870700005
PM 24802127
DA 2025-06-11
ER

PT J
AU Elbasan, Z
   Sahin, DY
   Gür, M
   Seker, T
   Kivrak, A
   Akyol, S
   Sümbül, Z
   Kuloglu, O
   Çayli, M
AF Elbasan, Z.
   Sahin, D. Y.
   Gur, M.
   Seker, T.
   Kivrak, A.
   Akyol, S.
   Sumbul, Z.
   Kuloglu, O.
   Cayli, M.
TI Serum uric acid and slow coronary flow in cardiac syndrome X
SO HERZ
LA English
DT Article
DE Cardiac syndrome X; Slow coronary flow; Serum uric acid; Correlation;
   Prognosis
ID BLOOD-FLOW; ASSOCIATION; ARTERIES; LEVEL
AB It has been recently shown that cardiac syndrome X (CSX) patients with slow coronary flow (SCF) have a worse long-term prognosis than those with normal coronary flow. Increased uric acid levels were shown to be associated with atherosclerosis, oxidative stress, and endothelial dysfunction. The purpose of the study was to investigate the relationship between coronary flow assessed with TIMI frame count (TFC) and serum uric acid (SUA) levels in patients with CSX.
   The study population consisted of 113 consecutive patients with typical cardiac CSX and 41 controls without cardiac CSX. Frequencies of risk factors as well as biochemical and hematological data were recorded for all participants. Coronary blood flow was evaluated by TFC. All patients with a TFC greater than two standard deviations from the published normal range for any one of the three vessels were accepted as having slow coronary flow (SCF group), while those whose TFC values fell within the standard deviation of the published normal range for all of the three vessels were considered to have normal coronary flow.
   Of the 113 CSX patients enrolled, 40 (35.4%) had SCF. The mean TFC value was strongly positively correlated with SUA level, but weakly correlated with male sex, hypertension, diabetes, smoking, serum creatinine level, and hemoglobin. Multivariate regression analysis showed that only the SUA level was independently associated with SCF. The cut-off value for uric acid obtained by the ROC curve analysis was 4.55 mg/dl for the prediction of SCF (sensitivity, 77.5%; specificity, 73.6%).
   The SUA level is independently associated with SCF in patients with CSX.
C1 [Elbasan, Z.; Sahin, D. Y.; Gur, M.; Seker, T.; Kivrak, A.; Akyol, S.; Sumbul, Z.; Kuloglu, O.; Cayli, M.] Adana Numune Educ & Res Hosp, Dept Cardiol, Adana, Turkey.
C3 Adana Numune Training & Research Hospital
RP Sahin, DY (corresponding author), Adana Numune Educ & Res Hosp, Dept Cardiol, Adana, Turkey.
EM dysahin79@hotmail.com
RI AKYOL, SELAHATTİN/CAG-1617-2022; ELBASAN, ZAFER/W-3376-2018
OI ELBASAN, ZAFER/0000-0001-9422-1995; Seker, Taner/0000-0003-4254-907X
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NR 20
TC 11
Z9 13
U1 0
U2 4
PU URBAN & VOGEL
PI MUNICH
PA NEUMARKTER STRASSE 43, D-81673 MUNICH, GERMANY
SN 0340-9937
J9 HERZ
JI Herz
PD AUG
PY 2013
VL 38
IS 5
BP 544
EP 548
DI 10.1007/s00059-012-3735-5
PG 5
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 208ET
UT WOS:000323660500015
PM 23338958
DA 2025-06-11
ER

PT J
AU Cissé, YM
   Chan, JC
   Nugent, BM
   Banducci, C
   Bale, TL
AF Cisse, Yasmine M.
   Chan, Jennifer C.
   Nugent, Bridget M.
   Banducci, Caitlin
   Bale, Tracy L.
TI Brain and placental transcriptional responses as a readout of maternal
   and paternal preconception stress are fetal sex specific
SO PLACENTA
LA English
DT Article
DE Preconception; Epigenetic; Sex; Lifetime stress; Transcriptome
ID PARENT-OFFSPRING CONFLICT; GENE-EXPRESSION; PREREPRODUCTIVE STRESS;
   EPIGENETIC REGULATION; GROWTH RESTRICTION; METABOLIC SYNDROME;
   PREGNANCY; PREECLAMPSIA; ADAPTATIONS; ENVIRONMENT
AB Introduction: Despite a wealth of epidemiological evidence that cumulative parental lifetime stress experiences prior to conception are determinant of offspring developmental trajectories, there is a lack of insight on how these previous stress experiences are stored and communicated intergenerationally. Preconception experiences may impact offspring development through alterations in transcriptional regulation of the placenta, a major determinant of offspring growth and sex-specific developmental outcomes. We evaluated the lasting influence of maternal and paternal preconception stress (PCS) on the mid-gestation placenta and fetal brain, utilizing their transcriptomes as proximate readouts of intergenerational impact.
   Methods: To assess the combined vs. dominant influence of maternal and paternal preconception environment on sex-specific fetal development, we compared transcriptional outcomes using a breeding scheme of one stressed parent, both stressed parents, or no stressed parents as controls.
   Results: Interestingly, offspring sex affected the directionality of transcriptional changes in response to PCS, where male tissues showed a predominant downregulation, and female tissues showed an upregulation. There was also an intriguing effect of parental sex on placental programming where paternal PCS drove more effects in female placentas, while maternal PCS produced more transcriptional changes in male placentas. However, in the fetal brain, maternal PCS produced overall more changes in gene expression than paternal PCS, supporting the idea that the intrauterine environment may have a larger overall influence on the developing brain than it does on shaping the placenta.
   Discussion: Preconception experiences drive changes in the placental and the fetal brain transcriptome at a critical developmental timepoint. While not determinant, these altered transcriptional states may underlie sex-biased risk or resilience to stressful experiences later in life.
C1 [Cisse, Yasmine M.; Chan, Jennifer C.; Nugent, Bridget M.; Banducci, Caitlin; Bale, Tracy L.] Univ Maryland, Sch Med, Dept Pharmacol, Baltimore, MD 21201 USA.
C3 University System of Maryland; University of Maryland Baltimore
RP Bale, TL (corresponding author), Univ Maryland, Sch Med, Dept Pharmacol, Ctr Epigenet Res Child Hlth & Brain Dev, HSF3,Room 9-171,670 W Baltimore St, Baltimore, MD 21201 USA.; Bale, TL (corresponding author), Univ Maryland, Sch Med, Dept Psychiat, Ctr Epigenet Res Child Hlth & Brain Dev, HSF3,Room 9-171,670 W Baltimore St, Baltimore, MD 21201 USA.
EM tbale@som.umaryland.edu
OI Nugent, Bridget/0000-0001-8450-0843
FU National Institutes of Health [ES028202, MH108286, HD097093,
   F32HD101301]
FX This work was supported by the National Institutes of Health grants
   ES028202, MH108286, HD097093 (TLB), and F32HD101301 (YMC).
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NR 84
TC 15
Z9 15
U1 0
U2 12
PU W B SAUNDERS CO LTD
PI LONDON
PA 32 JAMESTOWN RD, LONDON NW1 7BY, ENGLAND
SN 0143-4004
EI 1532-3102
J9 PLACENTA
JI Placenta
PD OCT
PY 2020
VL 100
BP 164
EP 170
DI 10.1016/j.placenta.2020.06.019
PG 7
WC Developmental Biology; Obstetrics & Gynecology; Reproductive Biology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Developmental Biology; Obstetrics & Gynecology; Reproductive Biology
GA NV9JS
UT WOS:000574628800020
PM 32980048
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Jaganjac, M
   Milkovic, L
   Gegotek, A
   Cindric, M
   Zarkovic, K
   Skrzydlewska, E
   Zarkovic, N
AF Jaganjac, Morana
   Milkovic, Lidija
   Gegotek, Agnieszka
   Cindric, Marina
   Zarkovic, Kamelija
   Skrzydlewska, Elzbieta
   Zarkovic, Neven
TI The relevance of pathophysiological alterations in redox signaling of
   4-hydroxynonenal for pharmacological therapies of major
   stress-associated diseases
SO FREE RADICAL BIOLOGY AND MEDICINE
LA English
DT Article
DE 4-hydroxynonenal; Lipid peroxidation; Oxidative stress; Metabolic
   syndrome; Diabetes mellitus; Obesity; Inflammation; Cardiovascular
   diseases; Atherosclerosis; Neurodegeneration; Alzheimer's disease;
   Parkinson's disease; Cancer; Growth control; Anti-cancer therapy; Redox
   signaling; Psoriasis
ID LIPID-PEROXIDATION PRODUCT; NF-KAPPA-B; HUMAN SUBCUTANEOUS ADIPOGENESIS;
   GAMMA-GLUTAMYL-TRANSPEPTIDASE; ACID-BINDING PROTEIN; OXIDATIVE STRESS;
   REACTIVE OXYGEN; ALZHEIMER-DISEASE; ATHEROSCLEROTIC LESIONS;
   EICOSAPENTAENOIC ACID
AB Modern analytical methods combined with the modern concepts of redox signaling revealed 4-hydroxy-2nonenal (4-HNE) as particular growth regulating factor involved in redox signaling under physiological and pathophysiological circumstances. In this review current knowledge of the relevance of 4-HNE as "the second messenger of reactive oxygen species" (ROS) in redox signaling of representative major stress-associated diseases is briefly summarized. The findings presented allow for 4-HNE to be considered not only as second messenger of ROS, but also as one of fundamental factors of the stress-and age-associated diseases. While standard, even modern concepts of molecular medicine and respective therapies in majority of these diseases target mostly the disease-specific symptoms. 4-HNE, especially its protein adducts, might appear to be the bioactive markers that would allow better monitoring of specific pathophysiological processes reflecting their complexity. Eventually that could help development of advanced integrative medicine approach for patients and the diseases they suffer from on the personalized basis implementing biomedical remedies that would optimize beneficial effects of ROS and 4-HNE to prevent the onset and progression of the illness, perhaps even providing the real cure.
C1 [Jaganjac, Morana] Anti Doping Lab Qatar, Qatar Analyt & BioRes Lab, Sport City St, Doha, Qatar.
   [Milkovic, Lidija; Zarkovic, Neven] Rudjer Boskovic Inst, Lab Oxidat Stress, Div Mol Med, Bijenicka 54, Zagreb, Croatia.
   [Gegotek, Agnieszka; Skrzydlewska, Elzbieta] Med Univ Bialystok, Dept Analyt Chem, Mickiewicza 2D, PL-15222 Bialystok, Poland.
   [Cindric, Marina; Zarkovic, Kamelija] Univ Zagreb, Univ Hosp Ctr Zagreb, Sch Med, Div Pathol, Kispaticeva 12, Zagreb, Croatia.
C3 Anti Doping Laboratory (Qatar); Rudjer Boskovic Institute; Medical
   University of Bialystok; University of Zagreb; UNIVERSITY ZAGREB
   HOSPITAL
RP Zarkovic, N (corresponding author), Rudjer Boskovic Inst, LabOS, Bijenicka 54, HR-1000 Zagreb, Croatia.
EM zarkovic@irb.hr
RI Jaganjac, Morana/AAX-2526-2020; Gęgotek, Agnieszka/GVU-1667-2022;
   Zarkovic, Neven/AAG-5836-2019; Milkovic, Lidija/F-5097-2019
OI Zarkovic, Neven/0000-0001-5032-0369; Milkovic,
   Lidija/0000-0002-4484-039X; Skrzydlewska, Elzbieta/0000-0001-5397-7139;
   Gegotek, Agnieszka/0000-0002-5240-1346; Jaganjac,
   Morana/0000-0001-5051-1843
FU Polish National Agency for Academic Exchange (NAWA) as part of the
   International Academic Partnerships [PPI/APM/2018/00015/U/001]
FX Cooperation between coauthors is financed by the Polish National Agency
   for Academic Exchange (NAWA) as part of the International Academic
   Partnerships (PPI/APM/2018/00015/U/001). On the occasion of the 20th
   anniversary of the International 4-HNE Club the authors also wish to
   thank the other researchers revealing importance of 4-HNE as "second
   messenger of reactive oxygen species" in health and in stress-and
   age-associated diseases.
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NR 356
TC 80
Z9 83
U1 0
U2 16
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0891-5849
EI 1873-4596
J9 FREE RADICAL BIO MED
JI Free Radic. Biol. Med.
PD SEP
PY 2020
VL 157
SI SI
BP 128
EP 153
DI 10.1016/j.freeradbiomed.2019.11.023
PG 26
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA NA9GR
UT WOS:000560125700010
PM 31756524
OA Green Published
DA 2025-06-11
ER

PT J
AU Tauman, R
   Shalitin, S
   Lavie, L
AF Tauman, Riva
   Shalitin, Shlomit
   Lavie, Lena
TI Oxidative stress in obese children and adolescents with and without type
   2 diabetes mellitus is not associated with obstructive sleep apnea
SO SLEEP AND BREATHING
LA English
DT Article
DE Insulin resistance; Type 2 diabetes mellitus; Obesity; Obstructive sleep
   apnea; Ox-LDL
ID CARDIOVASCULAR RISK-FACTORS; CIRCULATING OXIDIZED LDL; BODY-MASS-INDEX;
   INSULIN-RESISTANCE; LIPID-PEROXIDATION; INFLAMMATION; DISEASE
AB PurposeObesity, obstructive sleep apnea (OSA), and type 2 diabetes mellitus (T2DM) are associated with chronic low-grade inflammation and oxidative stress. In adults, increased lipid peroxidation, a marker of oxidative stress, was found in both metabolic syndrome and OSA. Studies on oxidative stress in children with T2DM and OSA are scarce.MethodsPlasma oxidized low-density lipoprotein (Ox-LDL) levels were evaluated in obese children and adolescents with/without T2DM, and the contribution of OSA to oxidative stress was investigated.ResultsTen patients with T2DM, 8 with impaired glucose tolerance (IGT), and 20 body mass index-standard deviation score (BMI-SDS)-matched non-diabetic children (controls) were studied. They all underwent overnight polysomnography. Fasting plasma concentrations of Ox-LDL were measured and compared to the glycemic status and to the presence of OSA. Fourteen patients (36%) were diagnosed with OSA and 21 (55%) with hypertension. There were no significant group differences in plasma Ox-LDL levels or between patients with/without OSA. Plasma Ox-LDL levels were significantly higher among patients with hypertension compared to controls (P=0.01), while they correlated with homeostasis model assessment (P=0.02), BMI-SDS (P=0.049), and systolic blood pressure (P=0.002).ConclusionsThe findings of this pilot study suggest that increased lipid peroxidation is associated with insulin resistance and hypertension in obese children and adolescents, while OSA has most likely minor influence.
C1 [Tauman, Riva] Tel Aviv Med Ctr & Sch Med, Sleep Disorders Ctr, 6 Weizmann St, IL-6423906 Tel Aviv, Israel.
   [Tauman, Riva; Shalitin, Shlomit] Tel Aviv Univ, Sackler Sch Med, Tel Aviv, Israel.
   [Shalitin, Shlomit] Schneider Childrens Med Ctr Israel, Jesse Z & Lea Shafer Inst Endocrinol & Diabet, Petah Tiqwa, Israel.
   [Lavie, Lena] Technion Israel Inst Technol, Ruth & Bruce Rappaport Fac Med, Unit Anat & Cell Biol, Lloyd Rigler Sleep Apnea Res Lab, Haifa, Israel.
C3 Tel Aviv University; Sackler Faculty of Medicine; Tel Aviv University;
   Sackler Faculty of Medicine; Tel Aviv University; Technion Israel
   Institute of Technology; Rappaport Faculty of Medicine
RP Tauman, R (corresponding author), Tel Aviv Med Ctr & Sch Med, Sleep Disorders Ctr, 6 Weizmann St, IL-6423906 Tel Aviv, Israel.; Tauman, R (corresponding author), Tel Aviv Univ, Sackler Sch Med, Tel Aviv, Israel.
EM tauman@tlvmc.gov.il
RI Lavandero, Sergio/B-6001-2013
OI Tauman, Riva/0000-0002-6574-3601
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NR 36
TC 10
Z9 10
U1 0
U2 3
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1520-9512
EI 1522-1709
J9 SLEEP BREATH
JI Sleep Breath.
PD MAR
PY 2019
VL 23
IS 1
BP 117
EP 123
DI 10.1007/s11325-018-1670-2
PG 7
WC Clinical Neurology; Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Respiratory System
GA HQ8CF
UT WOS:000462650800013
PM 29804216
DA 2025-06-11
ER

PT J
AU He, XW
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AF He, Xiaowei
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   Sun, Yue
   Chang, Xiaoai
   Zhu, Yunxia
   Tang, Wei
TI Perfluorooctanoic acid promotes pancreatic β cell dysfunction and
   apoptosis through ER stress and the ATF4/CHOP/TRIB3 pathway
SO ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
LA English
DT Article
DE Perfluorooctanoic acid; Pancreatic beta cell dysfunction; Apoptosis;
   Endoplasmic reticulum stress; TRIB3
ID PERFLUORINATED CHEMICALS; GLUCOSE-HOMEOSTASIS; METABOLIC SYNDROME;
   POLYFLUOROALKYL SUBSTANCES; PERFLUOROALKYL SUBSTANCES;
   ENDOPLASMIC-RETICULUM; TRIBBLES HOMOLOG; FETAL-GROWTH; CORD BLOOD;
   EXPOSURE
AB Perfluorooctanoic acid (PFOA), a widely used chemical substance, causes an increased risk of human type 2 diabetes (T2D), but its underlying mechanism is not well elucidated. The aim of the present study was to investigate whether PFOA regulates the functions of pancreatic beta cells, which are specialized for the biosynthesis and secretion of insulin. The treatment of the mouse pancreatic P cell line (MIN6 cells) with PFOA caused a time- and dose-dependent inhibition of cell viability in CCK-8 assays. Annexin V/PI and TUNEL staining results confirmed that exposure to a high PFOA dose (500 mu M) promoted apoptosis of beta cells, while a low dose (300 mu M) had no effects on beta cell survival. PFOA treatment, even at a low dose, diminished glucose-stimulated insulin secretion (GSIS) in both primary islet perfusion and MIN6 cell experiments. RNA-sequencing data showed significantly increased expression of endoplasmic reticulum (ER) stress-associated genes, with tribbles homolog 3 (Trib3) ranking first among the altered genes. The activation of ER stress pathways was verified by qRT-PCR assays, and the ATF4/CHOP/TRIB3 pathway contributed to PFOA-induced beta cell damage. The inhibition of TRIB3 expression significantly protected MIN6 cells from PFOA-induced GSIS defects and apoptosis by ameliorating ER stress. These findings reveal a link between ER stress and PFOA-induced beta cell defects, opening up a new set of questions about the pathogenesis of T2D due to environmental chemicals.
C1 [He, Xiaowei; Wu, Dan; Tang, Wei] Nanjing Med Univ, Dept Endocrinol, Islet Cell Senescence & Funct Res Lab, Affiliated Geriatr Hosp,Jiangsu Prov Geriatr Hosp, 30 Luojia Rd, Nanjing 210024, Jiangsu, Peoples R China.
   [Xu, Yanan] Nanjing Med Univ, Dept Endocrinol, Affiliated Hosp 2, 121 Jiangjia Yuan, Nanjing 210011, Jiangsu, Peoples R China.
   [Zhang, Yaqin; Sun, Yue; Chang, Xiaoai; Zhu, Yunxia] Nanjing Med Univ, Dept Biochem & Mol Biol, Key Lab Human Funct Genom Jiangsu Prov, 101 Longmian Ave, Nanjing 211166, Jiangsu, Peoples R China.
C3 Nanjing Medical University; Nanjing Medical University; Nanjing Medical
   University
RP Tang, W (corresponding author), Nanjing Med Univ, Dept Endocrinol, Islet Cell Senescence & Funct Res Lab, Affiliated Geriatr Hosp,Jiangsu Prov Geriatr Hosp, 30 Luojia Rd, Nanjing 210024, Jiangsu, Peoples R China.
EM drtangwei@njmu.edu.cn
RI Tang, Wei/IZQ-1283-2023; Zhu, Yunxia/G-6273-2014; He, XW/JXN-0620-2024
OI Zhu, Yunxia/0000-0002-4597-4445
FU National Natural Science Foundation of China [81770773, 81870531,
   82070843]; Natural Science Foundation of Jiangsu Province [BK20171499];
   Science and Technology Development Fund of Nanjing Medical University
   [NMUB2018172]; Scientific Research Project of Jiangsu Health Vocational
   College [JKFY201809]
FX This work was supported by grants from the National Natural Science
   Foundation of China (81770773 to W. T.; 81870531 and 82070843 to Y-X.
   Z.), the Natural Science Foundation of Jiangsu Province (BK20171499),
   the Science and Technology Development Fund of Nanjing Medical
   University (NMUB2018172), and the Scientific Research Project of Jiangsu
   Health Vocational College (JKFY201809).
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NR 63
TC 7
Z9 9
U1 1
U2 17
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0944-1344
EI 1614-7499
J9 ENVIRON SCI POLLUT R
JI Environ. Sci. Pollut. Res.
PD DEC
PY 2022
VL 29
IS 56
BP 84532
EP 84545
DI 10.1007/s11356-022-21188-9
EA JUL 2022
PG 14
WC Environmental Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology
GA 6I1PI
UT WOS:000820581800007
PM 35788477
DA 2025-06-11
ER

PT J
AU Tamashiro, KLK
   Terrillion, CE
   Hyun, J
   Koenig, JI
   Moran, TH
AF Tamashiro, Kellie L. K.
   Terrillion, Chantelle E.
   Hyun, Jayson
   Koenig, James I.
   Moran, Timothy H.
TI Prenatal Stress or High-Fat Diet Increases Susceptibility to
   Diet-Induced Obesity in Rat Offspring
SO DIABETES
LA English
DT Article
ID DEPENDENT DIABETES-MELLITUS; PITUITARY-ADRENAL-AXIS; BODY-WEIGHT;
   GLUCOCORTICOID EXPOSURE; GLUCOSE-INTOLERANCE; METABOLIC SYNDROME;
   SCHIZOPHRENIA; OVERWEIGHT; CORTICOSTERONE; PREVALENCE
AB OBJECTIVE-Perturbations to the prenatal environment have been associated with the development of adult chronic disease, findings that gave rise to the "Barker Hypothesis" or the "developmental origins of adult disease" concept. In this study, we used an animal model to determine the metabolic consequences of maternal prenatal stress and high-fat feeding on the developing offspring.
   RESEARCH DESIGN AND METHODS-Pregnant female Sprague-Dawley rats were maintained on standard chow or 60% high-fat diet throughout gestation and lactation. Half of each group were exposed to a novel variable stress paradigm during the 3rd week of gestation, whereas control dams were left undisturbed. Body weight, body composition, glucose tolerance, and endocrine parameters were measured in offspring through early adulthood.
   RESULTS-Male and female pups from dams that experienced prenatal stress and/or were on a high-fat diet weighed more beginning on postnatal day 7 compared with standard chow-control pups. Access to high-fat diet at weaning increased the body weight effect through early adulthood and was attributable to greater adiposity. Pups weaned onto standard chow diet showed no significant difference in glucose clearance or insulin secretion. However, pups weaned onto high-fat diet had impaired glucose tolerance if their dams were on a high-fat diet, experienced prenatal stress, or both.
   CONCLUSIONS-Our data demonstrate that prenatal stress and/or high-fat diet during the intrauterine or postnatal environment affects offspring in a manner that increases their susceptibility to diet-induced obesity and leads to secondary adverse metabolic consequences. Diabetes 58:1116-1125, 2009
C1 [Tamashiro, Kellie L. K.; Terrillion, Chantelle E.; Hyun, Jayson; Moran, Timothy H.] Johns Hopkins Univ, Sch Med, Dept Psychiat, Baltimore, MD 21205 USA.
   [Koenig, James I.] Univ Maryland, Sch Med, Dept Psychiat, Maryland Psychiat Res Ctr, Baltimore, MD 21201 USA.
C3 Johns Hopkins University; University System of Maryland; University of
   Maryland Baltimore
RP Tamashiro, KLK (corresponding author), Johns Hopkins Univ, Sch Med, Dept Psychiat, Baltimore, MD 21205 USA.
EM ktamashiro@jhmi.edu
OI Koenig, James/0000-0003-1930-6870; Tamashiro, Kellie/0000-0002-9398-8796
FU National Institutes of Health [K99HD055030, R01DK077623, R01MH073826]
FX This study was supported by National Institutes of Health grants
   K99HD055030 (to K.L.K.T.), R01DK077623 (to T.H.M.), and R01MH073826 (to
   J.I.K.).
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NR 50
TC 232
Z9 267
U1 0
U2 15
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0012-1797
EI 1939-327X
J9 DIABETES
JI Diabetes
PD MAY
PY 2009
VL 58
IS 5
BP 1116
EP 1125
DI 10.2337/db08-1129
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 440YX
UT WOS:000265736700011
PM 19188431
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Li, C
   Li, YL
   Gai, ZB
AF Li, Chao
   Li, Yunlun
   Gai, Zhibo
TI Bile Acids and Farnesoid X Receptor: Novel Target for the Treatment of
   Diabetic Cardiomyopathy
SO CURRENT PROTEIN & PEPTIDE SCIENCE
LA English
DT Review
DE Bile Acids; farnesoid X receptor; diabetic cardiomyopathy; oxidative
   stress; inflammation; mitochondrial dysfunction
ID NECROSIS-FACTOR-ALPHA; OXIDATIVE STRESS; CELL-DEATH; CONTRACTILE
   DYSFUNCTION; CARDIAC DYSFUNCTION; HEART-FAILURE; INFLAMMATION;
   ACTIVATION; FIBROSIS; FXR
AB Diabetes mellitus (DM) has become an increasingly common disease with high disability and mortality rates. Diabetes complications are the main cause of diabetes death and about 50% of diabetic patients died from heart disease in developed countries reported by World Health Organization. Diabetic cardiomyopathy (DCM) has been considered as a high incidence and serious complication of DM and plays a key role in the incidence and development of diabetes related heart failure. Metabolism dysregulation is regarded as an important and earlier factor occurred in the pathogenesis of DCM. Insulin resistance, oxidative stress, inflammation and mitochondrial dysfunction also contribute to the development of DCM. Farnesoid X Receptor (FXR) is a member of nuclear receptor superfamily, and plays a critical role in regulating lipid and glucose metabolism, oxidative stress and inflammation. FXR is activated by primary bile acids (BAs) such as chenodeoxycholic acid, cholic acid and synthetic agonists such as obeticholic acid. BAs are the main active ingredients of many natural products and traditional medicines, especially bile or gallstones in animals, such as calculus bovis. Due to the regulatory effect of FXR on glucose and lipid metabolism, oxidative stress and inflammation, the treatment of BAs and FXR agonists for metabolic syndrome and DCM have gained more attention. This review will focus on the pathogenesis of diabetic cardiomyopathy and the regulatory effect of BAs and FXR on DCM.
C1 [Li, Chao; Li, Yunlun; Gai, Zhibo] Shandong Univ Tradit Chinese Med, Jinan 250000, Shandong, Peoples R China.
   [Li, Chao; Gai, Zhibo] Univ Hosp Zurich, Dept Clin Pharmacol & Toxicol, CH-8032 Zurich, Switzerland.
C3 Shandong University of Traditional Chinese Medicine; University of
   Zurich; University Zurich Hospital
RP Li, YL; Gai, ZB (corresponding author), Shandong Univ Tradit Chinese Med, Jinan 250000, Shandong, Peoples R China.
EM yunlun.lee@hotmail.com; gaizhibo@gmail.com
RI Li, Chao/ABD-9324-2021; GAI, ZHIBO/ABE-7650-2020
OI Li, Chao/0000-0003-1568-9704; Gai, Zhibo/0000-0003-1673-6541
FU National Nature Science Foundation of China [81473653, 81774242,
   81473369]
FX This work was supported by National Nature Science Foundation of China
   grant No's. 81473653, 81774242 and 81473369.
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NR 86
TC 10
Z9 14
U1 4
U2 36
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1389-2037
EI 1875-5550
J9 CURR PROTEIN PEPT SC
JI Curr. Protein Pept. Sci.
PY 2019
VL 20
IS 10
BP 976
EP 983
DI 10.2174/1389203720666190726152847
PG 8
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA IZ7DT
UT WOS:000487248100004
PM 31362653
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Favre, J
   Yildirim, C
   Leyen, TA
   Chen, WJY
   van Genugten, RE
   van Golen, LW
   Garcia-Vallejo, JJ
   Musters, R
   Baggen, J
   Fontijn, R
   Kraan, TV
   Serne, E
   Koolwijk, P
   Diamant, M
   Horrevoets, AJG
AF Favre, Julie
   Yildirim, Cansu
   Leyen, Thomas A.
   Chen, Weena J. Y.
   van Genugten, Renate E.
   van Golen, Larissa W.
   Garcia-Vallejo, Juan-Jesus
   Musters, Rene
   Baggen, Josefien
   Fontijn, Ruud
   Kraan, Tineke van der Pouw
   Serne, Erik
   Koolwijk, Pieter
   Diamant, Michaela
   Horrevoets, Anton J. G.
TI Palmitic acid increases pro-oxidant adaptor protein p66Shc expression
   and affects vascularization factors in angiogenic mononuclear cells:
   Action of resveratrol
SO VASCULAR PHARMACOLOGY
LA English
DT Article
DE Diabetes mellitus; Oxidative stress; Fatty acid; Endothelial progenitor
   cells
ID ENDOTHELIAL PROGENITOR CELLS; NITRIC-OXIDE; FATTY-ACIDS;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; GENE-EXPRESSION; SIRT1;
   DYSFUNCTION; ACTIVATION; SENESCENCE
AB A defect in neo-vascularization process involving circulating angiogenic mononuclear cells (CACs) dysfunction is associated with diabetes. We showed that oxidative stress was elevated in CACs cultured from blood of individuals with metabolic syndrome (MetS) and diabetes. We then assessed the action of palmitic acid (PA), a deregulated and increased NEFA in metabolic disorders, focusing on its oxidant potential. We observed that the phyto-polyphenol resveratrol normalized oxidative stress both in CACs isolated from MetS patients or treated with PA. Resveratrol further decreased the deleterious action of PA on gene expression of vascularization factors (TNF alpha, VEGF-A, SDF1 alpha, PECAM-1, VEGFR2, Tie2 and CXCR4) and improved CAC motility. Particularly, resveratrol abolished the PA-induced over-expression of the pro-oxidant protein p66Shc. Neither KLF2 nor SIRT1, previously shown in resveratrol and p66Shc action, was directly involved. Silencing p66Shc normalized PA action on VEGF-A and TNF alpha specifically, without abolishing the PA-induced oxidative stress, which suggests a deleterious role of p66Shc independently of any major modulation of the cellular oxidative status in a high NEFA levels context. Besides showing that resveratrol reverses PA-induced harmful effects on human CAC function, certainly through profound cellular modifications, we establish p66Shc as a major therapeutic target in metabolic disorders, independent from glycemic control. (C) 2015 Elsevier Inc. All rights reserved.
C1 [Favre, Julie; Yildirim, Cansu; Leyen, Thomas A.; Garcia-Vallejo, Juan-Jesus; Baggen, Josefien; Fontijn, Ruud; Kraan, Tineke van der Pouw; Horrevoets, Anton J. G.] Vrije Univ Amsterdam Med Ctr, Dept Mol Cell Biol, NL-1081 BT Amsterdam, Netherlands.
   [Chen, Weena J. Y.; van Genugten, Renate E.; van Golen, Larissa W.; Serne, Erik; Diamant, Michaela] Vrije Univ Amsterdam Med Ctr, Ctr Internal Med, Dept Diabet, NL-1081 BT Amsterdam, Netherlands.
   [Musters, Rene; Koolwijk, Pieter] Vrije Univ Amsterdam Med Ctr, Dept Physiol, NL-1081 BT Amsterdam, Netherlands.
C3 Vrije Universiteit Amsterdam; VU UNIVERSITY MEDICAL CENTER; Vrije
   Universiteit Amsterdam; VU UNIVERSITY MEDICAL CENTER; Vrije Universiteit
   Amsterdam; VU UNIVERSITY MEDICAL CENTER
RP Horrevoets, AJG (corresponding author), Vrije Univ Amsterdam Med Ctr, Fac Med, Boechorstr 7, NL-1081 BT Amsterdam, Netherlands.
EM aj.horrevoets@vumc.nl
RI Vallejo, Juan/AAA-3765-2020; YILDIRIM, CANSU/ABB-8045-2021;
   Garcia-Vallejo, Juan J./H-4162-2012
OI YILDIRIM, CANSU/0000-0002-9015-6636; Serne, Erik/0000-0003-0657-7225;
   Garcia-Vallejo, Juan J./0000-0001-6238-7069; Favre,
   Julie/0000-0003-1044-0950
FU European Marie Curie's IEF fellowship [FP7 254644 EPC]
FX This work was supported by a European Marie Curie's IEF fellowship (FP7
   254644 EPC repair project). The content is solely the responsibility of
   the authors and does not necessarily represent the official views of the
   ERC. We thank Dr. Gilles Kauffenstein for his help in finalizing the
   manuscript.
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NR 42
TC 6
Z9 6
U1 0
U2 9
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1537-1891
EI 1879-3649
J9 VASC PHARMACOL
JI Vasc. Pharmacol.
PD DEC
PY 2015
VL 75
BP 7
EP 18
DI 10.1016/j.vph.2015.08.003
PG 12
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA CZ3UH
UT WOS:000367029000002
PM 26254104
DA 2025-06-11
ER

PT J
AU Ergaz, Z
   Neeman-azulay, M
   Weinstein-Fudim, L
   Weksler-Zangen, S
   Shoshani-Dror, D
   Szyf, M
   Ornoy, A
AF Ergaz, Zivanit
   Neeman-azulay, Meytal
   Weinstein-Fudim, Liza
   Weksler-Zangen, Sarah
   Shoshani-Dror, Dana
   Szyf, Moshe
   Ornoy, Asher
TI Diabetes in the Cohen Rat Intensifies the Fetal Pancreatic Damage
   Induced by the Diabetogenic High Sucrose Low Copper Diet
SO BIRTH DEFECTS RESEARCH PART B-DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY
LA English
DT Article
DE Rat; pancreas; gestational diabetes; fetus; copper; oxidative stress;
   global DNA methylation; apoptosis
ID STIMULATED INSULIN-SECRETION; NF-KAPPA-B; OXIDATIVE STRESS; GROWTH
   RESTRICTION; METABOLIC SYNDROME; MATERNAL OBESITY; EMBRYOS; MODEL;
   METHYLATION; APOPTOSIS
AB Intrauterine hyperglycemic environment could harm the fetus making it more susceptible to develop postnatal glucose intolerance. A possible mechanism is compromise of the fetal pancreatic development. We previously found that a high sucrose low copper diabetogenic diet induces type 2 diabetes in the Cohen diabetic sensitive rats, but not in the Sabra control rats. However, oxidative stress was observed in the placenta and term fetal liver of diabetic and nondiabetic controls. We now investigated whether the fetal pancreas is affected by this diet and whether the effects result from oxidative stress, maternal hyperglycemia, or both. Term fetal pancreases were evaluated for morphology, beta cells, oxidative stress, apoptosis, and DNA methylation. There were no microscopic changes in hematoxylin and eosin stained sections and beta cells immunostaining in the pancreas of fetuses of both strains. Fetuses of the sensitive strain fed diabetogenic diet had significantly higher activity of superoxide dismutase and catalase, elevated levels of low molecular weight antioxidants, and more intense immunostaining for nuclear factor kappa-B and hypoxia inducing factor-1. Both strains fed diabetogenic diet had increased immunostaining for Bcl-2-like protein and caspase 3 and decreased immunostaining for 5-methylcytosine in their islets and acini. Our data suggest that maternal diabetogenic diet alters apoptotic rate and epigenetic steady states in the term fetal pancreas, unrelated to maternal diabetes. Maternal hyperglycemia further increases pancreatic oxidative stress, aggravating the pancreatic damage. The diet-induced insults to the fetal pancreas may be an important contributor to the high susceptibility to develop diabetes following metabolic intrauterine insults. (C) 2016 Wiley Periodicals, Inc.
C1 [Ergaz, Zivanit; Neeman-azulay, Meytal; Weinstein-Fudim, Liza; Weksler-Zangen, Sarah; Shoshani-Dror, Dana; Ornoy, Asher] Hebrew Univ Jerusalem, Hadassah Med Sch, Lab Teratol, Dept Med Neurobiol, IL-91240 Jerusalem, Israel.
   [Ergaz, Zivanit] Hebrew Univ Jerusalem, Hadassah Med Ctr, Dept Neonatol, IL-91240 Jerusalem, Israel.
   [Weksler-Zangen, Sarah] Hebrew Univ Jerusalem, Hadassah Med Ctr, Dept Internal Med, Diabet Unit, IL-91240 Jerusalem, Israel.
   [Szyf, Moshe] McGill Univ, Dept Pharmacol & Therapeut, Montreal, PQ, Canada.
C3 Hebrew University of Jerusalem; Hebrew University of Jerusalem; Hadassah
   University Hospital; Hadassah University Medical Center; Hebrew
   University of Jerusalem; Hadassah University Medical Center; Hadassah
   University Hospital; McGill University
RP Ergaz, Z (corresponding author), Hebrew Univ Jerusalem, Hadassah Med Ctr, Dept Neonatol, IL-91240 Jerusalem, Israel.
EM zivanit@hadassah.org.il
RI Ornoy, Asher/J-8038-2018
OI Ornoy, Asher/0000-0002-7268-3512
FU Israeli American Binational Science Foundation [037 4352]; Cohen
   foundation
FX This work was supported by grant 037 4352 from the Israeli American
   Binational Science Foundation and the Cohen foundation.
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NR 49
TC 4
Z9 4
U1 0
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1542-9733
EI 1542-9741
J9 BIRTH DEFECTS RES B
JI Birth Defects Res. Part B-Dev. Reprod. Toxicol.
PD FEB
PY 2016
VL 107
IS 1
BP 21
EP 31
DI 10.1002/bdrb.21169
PG 11
WC Oncology; Genetics & Heredity; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Genetics & Heredity; Toxicology
GA DF5UB
UT WOS:000371416900002
PM 26748987
OA Bronze
DA 2025-06-11
ER

PT J
AU Xu, W
   Tan, L
   Wang, HF
   Jiang, T
   Tan, MS
   Tan, L
   Zhao, QF
   Li, JQ
   Wang, J
   Yu, JT
AF Xu, Wei
   Tan, Lan
   Wang, Hui-Fu
   Jiang, Teng
   Tan, Meng-Shan
   Tan, Lin
   Zhao, Qing-Fei
   Li, Jie-Qiong
   Wang, Jun
   Yu, Jin-Tai
TI Meta-analysis of modifiable risk factors for Alzheimer's disease
SO JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
LA English
DT Article
ID MILD COGNITIVE IMPAIRMENT; ARTERIAL STIFFNESS; PREVALENCE; DEMENTIA;
   OLDER; ATHEROSCLEROSIS; ASSOCIATION; CHALLENGES
AB Background The aetiology of Alzheimer's disease (AD) is believed to involve environmental exposure and genetic susceptibility. The aim of our present systematic review and meta-analysis was to roundly evaluate the association between AD and its modifiable risk factors.
   Methods We systematically searched PubMed and the Cochrane Database of Systematic Reviews from inception to July 2014, and the references of retrieved relevant articles. We included prospective cohort studies and retrospective case-control studies.
   Results 16 906 articles were identified of which 323 with 93 factors met the inclusion criteria for meta-analysis. Among factors with relatively strong evidence (pooled population > 5000) in our meta-analysis, we found grade I evidence for 4 medical exposures (oestrogen, statin, antihypertensive medications and non-steroidal anti-inflammatory drugs therapy) as well as 4 dietary exposures (folate, vitamin E/C and coffee) as protective factors of AD. We found grade I evidence showing that one biochemical exposure (hyperhomocysteine) and one psychological condition (depression) significantly increase risk of developing AD. We also found grade I evidence indicative of complex roles of pre-existing disease (frailty, carotid atherosclerosis, hypertension, low diastolic blood pressure, type 2 diabetes mellitus (Asian population) increasing risk whereas history of arthritis, heart disease, metabolic syndrome and cancer decreasing risk) and lifestyle (low education, high body mass index (BMI) in mid-life and low BMI increasing the risk whereas cognitive activity, current smoking (Western population), light-to-moderate drinking, stress, high BMI in late-life decreasing the risk) in influencing AD risk. We identified no evidence suggestive of significant association with occupational exposures.
   Conclusions Effective interventions in diet, medications, biochemical exposures, psychological condition, preexisting disease and lifestyle may decrease new incidence of AD.
C1 [Xu, Wei; Tan, Lan; Tan, Meng-Shan; Zhao, Qing-Fei; Li, Jie-Qiong; Wang, Jun; Yu, Jin-Tai] Qingdao Univ, Qingdao Municipal Hosp, Sch Med, Dept Neurol, Qingdao 266071, Peoples R China.
   [Tan, Lan; Wang, Hui-Fu; Jiang, Teng; Yu, Jin-Tai] Nanjing Med Univ, Qingdao Municipal Hosp, Dept Neurol, Qingdao, Peoples R China.
   [Tan, Lan; Tan, Lin; Yu, Jin-Tai] Ocean Univ China, Coll Med & Pharmaceut, Qingdao, Peoples R China.
   [Yu, Jin-Tai] Univ Calif San Francisco, Dept Neurol, Memory & Aging Ctr, San Francisco, CA 94158 USA.
C3 Qingdao University; Qingdao Municipal Hospital; Qingdao Municipal
   Hospital; Nanjing Medical University; Ocean University of China;
   University of California System; University of California San Francisco
RP Yu, JT (corresponding author), Univ Calif San Francisco, Dept Neurol, 675 Nelson Rising Lane,Suite 190,Box 1207, San Francisco, CA 94158 USA.
EM yu-jintai@163.com
RI Li, Jieqiong/LLM-6815-2024; Jiang, Teng/JPA-0287-2023; Yu,
   Jin-Tai/HDL-7766-2022; wang, huifu/I-6262-2013; Talbot,
   Nicholas/I-5618-2019; Wang, Jun/GLU-1829-2022; Xu, Wei/AAH-5585-2021
OI Jiang, Teng/0000-0003-4170-1156; Yu, Jin-Tai/0000-0002-7686-0547; Xu,
   Wei/0000-0002-3310-5875
CR [Anonymous], NEW ENGL J MED
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TC 435
Z9 479
U1 4
U2 255
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 0022-3050
EI 1468-330X
J9 J NEUROL NEUROSUR PS
JI J. Neurol. Neurosurg. Psychiatry
PD DEC
PY 2015
VL 86
IS 12
BP 1299
EP 1306
DI 10.1136/jnnp-2015-310548
PG 8
WC Clinical Neurology; Psychiatry; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Psychiatry; Surgery
GA CX7CU
UT WOS:000365859500005
PM 26294005
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Mortby, ME
   Janke, AL
   Anstey, KJ
   Sachdev, PS
   Cherbuin, N
AF Mortby, Moyra E.
   Janke, Andrew L.
   Anstey, Kaarin J.
   Sachdev, Perminder S.
   Cherbuin, Nicolas
TI High "Normal" Blood Glucose Is Associated with Decreased Brain Volume
   and Cognitive Performance in the 60s: The PATH through Life Study
SO PLOS ONE
LA English
DT Article
ID ALZHEIMERS-DISEASE; PLASMA-GLUCOSE; DIABETES-MELLITUS; RISK; DEMENTIA;
   ATROPHY; MRI; HYPERGLYCEMIA; DEPRESSION; ADULTS
AB Context: Type 2 diabetes is associated with cerebral atrophy, cognitive impairment and dementia. We recently showed higher glucose levels in the normal range not to be free of adverse effects and to be associated with greater hippocampal and amygdalar atrophy in older community-dwelling individuals free of diabetes.
   Objective: This study aimed to determine whether blood glucose levels in the normal range (<6.1 mmol/L) were associated with cerebral volumes in structures other than the hippocampus and amygdale, and whether these glucose-related regional volumes were associated with cognitive performance.
   Design, Setting and Participants: 210 cognitively healthy individuals (68-73 years) without diabetes, glucose intolerance or metabolic syndrome were assessed in the large, community-based Personality and Total Health Through Life (PATH) study.
   Main Outcome Measure: Baseline blood glucose levels in the normal range (3.2-6.1 mmol/l) were used to determine regional brain volumes and associated cognitive function at wave 3.
   Results: Higher blood glucose levels in the normal range were associated with lower grey/white matter regional volumes in the frontal cortices (middle frontal gyrus, inferior frontal gyrus precentral gyrus). Moreover, identified cerebral regions were associated with poorer cognitive performance and the structure-function associations were gender specific to men.
   Conclusion: These findings stress the need to re-evaluate what is considered as healthy blood glucose levels, and consider the role of higher normal blood glucose as a risk factor for cerebral health, cognitive function and dementia. A better lifetime management of blood glucose levels may contribute to improved cerebral and cognitive health in later life and possibly protect against dementia.
C1 [Mortby, Moyra E.; Anstey, Kaarin J.; Cherbuin, Nicolas] Australian Natl Univ, Ctr Res Ageing Hlth & Wellbeing, Canberra, ACT, Australia.
   [Janke, Andrew L.] Univ Queensland, Ctr Adv Imaging, Brisbane, Qld, Australia.
   [Sachdev, Perminder S.] Univ New S Wales, Inst Neuropsychiat, Sydney, NSW, Australia.
C3 Australian National University; University of Queensland; University of
   New South Wales Sydney
RP Mortby, ME (corresponding author), Australian Natl Univ, Ctr Res Ageing Hlth & Wellbeing, Canberra, ACT, Australia.
EM moyra.mortby@anu.edu.au
RI Anstey, Kaarin/A-3852-2008; Sachdev, Perminder/ABC-1137-2020; Mortby,
   Moyra/AAY-6075-2020; Cherbuin, Nicolas/A-8515-2008; Janke,
   Andrew/E-6149-2011; Sachdev, Perminder/H-3968-2015
OI Cherbuin, Nicolas/0000-0001-6481-0748; Janke,
   Andrew/0000-0003-0547-5171; Sachdev, Perminder/0000-0002-9595-3220;
   Mortby, Moyra/0000-0002-9568-6628; Anstey, Kaarin
   Jane/0000-0002-9706-9316
FU Dementia Collaborative Research Centres; NHMRC of Australia [973302,
   179805, 157125]; NHMRC [471501, 366756]
FX The study was supported by the Dementia Collaborative Research Centres
   and the NHMRC of Australia No. 973302, 179805, 157125. Nicolas Cherbuin
   and Kaarin Anstey are funded by NHMRC Fellowships No. 471501 and No.
   366756. The funders had no role in study design, data collection and
   analysis, decision to publish, or preparation of the manuscript.
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U1 0
U2 13
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD SEP 4
PY 2013
VL 8
IS 9
AR e73697
DI 10.1371/journal.pone.0073697
PG 9
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Science & Technology - Other Topics
GA 219OE
UT WOS:000324515600113
PM 24023897
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Patel, R
   Parmar, N
   Palit, SP
   Rathwa, N
   Ramachandran, AV
   Begum, R
AF Patel, Roma
   Parmar, Nishant
   Palit, Sayantani Pramanik
   Rathwa, Nirali
   Ramachandran, A. V.
   Begum, Rasheedunnisa
TI Diabetes mellitus and melatonin: Where are we?
SO BIOCHIMIE
LA English
DT Article
DE Melatonin; Diabetes therapeutics; Diabetes complications; Cellular
   stress; 0-cell regeneration
ID ENDOPLASMIC-RETICULUM STRESS; BETA-CELL APOPTOSIS; OXIDATIVE STRESS;
   MITOCHONDRIAL DYSFUNCTION; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   GLUCOSE-TOLERANCE; CIRCADIAN DISRUPTION; ANTIOXIDANT STATUS; MTNR1B
   VARIANTS
AB Diabetes mellitus (DM) and diabetes-related complications are amongst the leading causes of mortality worldwide. The international diabetes federation (IDF) has estimated 592 million people to suffer from DM by 2035. Hence, finding a novel biomolecule that can effectively aid diabetes management is vital, as other existing drugs have numerous side effects.Melatonin, a pineal hormone having antioxidative and anti-inflammatory properties, has been implicated in circadian dysrhythmia-linked DM. Reduced levels of melatonin and a functional link be-tween melatonin and insulin are implicated in the pathogenesis of type 2 diabetes (T2D). Additionally, genomic studies revealed that rare variants in melatonin receptor 1b (MTNR1B) are also associated with impaired glucose tolerance and increased risk of T2D. Moreover, exogenous melatonin treatment in cell lines, rodent models, and diabetic patients has shown a potent effect in alleviating diabetes and other related complications. This highlights the role of melatonin in glucose homeostasis. However, there are also contradictory reports on the effects of melatonin supplementation. Thus, it is essential to explore if melatonin can be taken from bench to bedside for diabetes management.This review summarizes the therapeutic potential of melatonin in various diabetic models and whether it can be considered a safe drug for managing diabetic complications and diabetic manifesta-tions like oxidative stress, inflammation, ER stress, mitochondrial dysfunction, metabolic dysregulation, etc.(c) 2022 Elsevier B.V. and Societe Francaise de Biochimie et Biologie Moleculaire (SFBBM). All rights reserved.
C1 [Patel, Roma; Parmar, Nishant; Palit, Sayantani Pramanik; Rathwa, Nirali; Begum, Rasheedunnisa] Maharaja Sayajirao Univ Baroda, Fac Sci, Dept Biochem, Vadodara 390002, Gujarat, India.
   [Ramachandran, A. V.] Navrachana Univ, Sch Sci, Div Life Sci, Vadodara 391410, Gujarat, India.
C3 Maharaja Sayajirao University Baroda
RP Begum, R (corresponding author), Maharaja Sayajirao Univ Baroda, Fac Sci, Dept Biochem, Vadodara 390002, Gujarat, India.
EM rasheedunnisab@yahoo.co.in
RI Begum, Rasheedunnisa/AAF-2981-2020; Patel, Roma/KVZ-0778-2024
OI Patel, Roma/0000-0002-6037-0498; BEGUM,
   RASHEEDUNNISA/0000-0003-3446-0980; A. V.,
   Ramachandran/0000-0002-2326-0994
FU Department of Biotechnology, New Delhi, India
   [BT/PR12584/MED/31/289/2014]; CSIR, New Delhi, India; UGC-NFST, New
   Delhi, India
FX RB gratefully acknowledges Department of Biotechnology
   (BT/PR12584/MED/31/289/2014), New Delhi, India, for the financial
   support. RP thanks CSIR, New Delhi, India, for awarding SRF. NR thanks
   UGC-NFST, New Delhi, India, for awarding SRF.
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NR 173
TC 34
Z9 34
U1 0
U2 19
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0300-9084
EI 1638-6183
J9 BIOCHIMIE
JI Biochimie
PD NOV
PY 2022
VL 202
BP 2
EP 14
DI 10.1016/j.biochi.2022.01.001
EA NOV 2022
PG 13
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 8D7RW
UT WOS:000918486700002
PM 35007648
DA 2025-06-11
ER

PT J
AU Nagiah, S
   Phulukdaree, A
   Chuturgoon, AA
AF Nagiah, Savania
   Phulukdaree, Alisa
   Chuturgoon, Anil A.
TI Lon protease and eiF2α are involved in acute, but not prolonged,
   antiretroviral induced stress response in HepG2 cells
SO CHEMICO-BIOLOGICAL INTERACTIONS
LA English
DT Article
DE NRTI; Lon; SIRT3; eIF2 alpha; Mitochondrial stress
ID MITOCHONDRIAL TOXICITY; OXIDATIVE STRESS; UP-REGULATION; SIRT3;
   PATHOGENESIS; DEGRADATION
AB Lon protease, an ATP dependent mitochondrial protease, is important in mitochondrial protein maintenance. Disruption of protein homeostasis and mitochondrial dysfunction is associated with lipodystrophy, metabolic syndrome and accelerated aging, and are commonly observed in patients on long term antiretroviral therapy. Sirtuin 3 (SIRT3) is a post-translational regulator of Lon and regulates antioxidant response. We previously showed the nucleoside analogues (NRTIs), Zidovudine (AZT; 7.1 mu M), Stavudine (d4T; 4 mu M), and Tenofovir (TFV; 1.2 mu M) induced oxidative stress and mitochondrial dysfunction in human hepatoma (HepG2) cells at 24 h (h) and 120 h. We conducted a mitochondrial proteomic assessment of homeostasis in the same model, using the same NRTIs. Protein expression of Lon, SIRT3, heat shock protein (HSP) 60, phospho-eukaryotic translation initiation factor 2 alpha (p-eIF2 alpha; Ser51) and phospho-c-jun N-terminal kinase (p-JNK; Thr183/Tyr185) were quantified by western blots. The data showed all stress responses were significantly increased in HepG2 cells by all antiretroviral drugs at 24 h (p < 0.0001); however, at 120 h, a significant depletion in the ATP-dependent proteins Lon (p = 0.00013) and HSP60 (p < 0.0001) was observed. Proteins initiated by endoplasmic reticulum stress: p-eIF2 alpha (p = 0.001) and p-JNK (p = 0.0029), were significantly reduced following prolonged treatment. SIRT3 was maintained at elevated levels in the treated cells following prolonged exposure (p < 0.001). We conclude that the ATP dependent proteins are more relevant to acute toxicity, while SIRT3 confers protection over prolonged periods of toxicity. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
C1 [Chuturgoon, Anil A.] Univ KwaZulu Natal, Coll Hlth Sci, Sch Lab Med & Med Sci, Discipline Med Biochem, Durban, South Africa.
   [Nagiah, Savania; Chuturgoon, Anil A.] Univ KwaZulu Natal, Howard Coll, Discipline Med Biochem, 3rd Floor George Campbell Bldg,King George Ave, ZA-4041 Durban, South Africa.
   [Phulukdaree, Alisa] Sch Med, Dept Physiol, Prinshof Campus,Dr Savage Rd, ZA-0083 Pretoria, Gauteng, South Africa.
   [Phulukdaree, Alisa] Univ Pretoria, Fac Hlth Sci, Dept Physiol, Prinshof Campus, ZA-0002 Pretoria, South Africa.
C3 University of Kwazulu Natal; University of Kwazulu Natal; University of
   Pretoria
RP Chuturgoon, AA (corresponding author), Univ KwaZulu Natal, Howard Coll, Discipline Med Biochem, 3rd Floor George Campbell Bldg,King George Ave, ZA-4041 Durban, South Africa.
EM 208509769@ukzn.stu.az.za; phulukdaree@up.ac.za; CHUTUR@ukzn.ac.za
RI Chuturgoon, Anil/AAE-5068-2021; Nagiah, Savania/AAC-4388-2020
FU National Research Foundation [84538]; College of Health Science
   (University of KwaZulu Natal) Doctoral Scholarship for Running Expense
FX The authors would like to recognise the National Research Foundation
   (Grant number: 84538) Innovation Doctoral Scholarship and College of
   Health Science (University of KwaZulu Natal) Doctoral Scholarship for
   Running Expense for financial support while conducting this study.
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NR 24
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U1 0
U2 6
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0009-2797
EI 1872-7786
J9 CHEM-BIOL INTERACT
JI Chem.-Biol. Interact.
PD MAY 25
PY 2016
VL 252
BP 82
EP 86
DI 10.1016/j.cbi.2016.03.021
PG 5
WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology
GA DL1UT
UT WOS:000375418800010
PM 27041070
DA 2025-06-11
ER

PT J
AU Lan, T
   Jiang, S
   Zhang, J
   Weng, QQ
   Yu, Y
   Li, HN
   Tian, S
   Ding, X
   Hu, S
   Yang, YQ
   Wang, WX
   Wang, LX
   Luo, DS
   Xiao, X
   Piao, SH
   Zhu, Q
   Rong, XL
   Guo, J
AF Lan, Tian
   Jiang, Shuo
   Zhang, Jing
   Weng, Qiqing
   Yu, Yang
   Li, Haonan
   Tian, Song
   Ding, Xin
   Hu, Sha
   Yang, Yiqi
   Wang, Weixuan
   Wang, Lexun
   Luo, Duosheng
   Xiao, Xue
   Piao, Shenghua
   Zhu, Qing
   Rong, Xianglu
   Guo, Jiao
TI Breviscapine alleviates NASH by inhibiting TGF-β-activated kinase
   1-dependent signaling
SO HEPATOLOGY
LA English
DT Article
ID FATTY LIVER-DISEASE; SCUTELLARIN; INFLAMMATION; PATHOGENESIS; STRESS;
   RESISTANCE; NAFLD; MICE
AB Background and Aims NAFLD is a key component of metabolic syndrome, ranging from nonalcoholic fatty liver to NASH, and is now becoming the leading cause of cirrhosis and HCC worldwide. However, due to the complex and unclear pathophysiological mechanism, there are no specific approved agents for treating NASH. Breviscapine, a natural flavonoid prescription drug isolated from the traditional Chinese herb Erigeron breviscapus, exhibits a wide range of pharmacological properties, including effects on metabolism. However, the anti-NASH efficacy and mechanisms of breviscapine have not yet been characterized. Approach and Results We evaluated the effects of breviscapine on the development of hepatic steatosis, inflammation, and fibrosis in vivo and in vitro under metabolic stress. Breviscapine treatment significantly reduced lipid accumulation, inflammatory cell infiltration, liver injury, and fibrosis in mice fed a high-fat diet, a high-fat/high-cholesterol diet, or a methionine- and choline-deficient diet. In addition, breviscapine attenuated lipid accumulation, inflammation, and lipotoxicity in hepatocytes undergoing metabolic stress. RNA-sequencing and multiomics analyses further indicated that the key mechanism linking the anti-NASH effects of breviscapine was inhibition of TGF-beta-activated kinase 1 (TAK1) phosphorylation and the subsequent mitogen-activated protein kinase signaling cascade. Treatment with the TAK1 inhibitor 5Z-7-oxozeaenol abrogated breviscapine-mediated hepatoprotection under metabolic stress. Molecular docking illustrated that breviscapine directly bound to TAK1. Conclusion Breviscapine prevents metabolic stress-induced NASH progression through direct inhibition of TAK1 signaling. Breviscapine might be a therapeutic candidate for the treatment of NASH.
C1 [Lan, Tian; Jiang, Shuo; Zhang, Jing; Weng, Qiqing; Yu, Yang; Li, Haonan; Ding, Xin; Yang, Yiqi; Wang, Weixuan; Wang, Lexun; Luo, Duosheng; Xiao, Xue; Piao, Shenghua; Zhu, Qing; Rong, Xianglu; Guo, Jiao] Guangdong Pharmaceut Univ, Inst Chinese Med, Guangzhou, Peoples R China.
   [Lan, Tian; Jiang, Shuo; Zhang, Jing; Weng, Qiqing; Yu, Yang; Li, Haonan; Ding, Xin; Yang, Yiqi; Wang, Weixuan; Wang, Lexun; Luo, Duosheng; Xiao, Xue; Piao, Shenghua; Zhu, Qing; Rong, Xianglu; Guo, Jiao] Guangdong Metab Dis Res Ctr Integrated Chinese &, Guangzhou, Peoples R China.
   [Lan, Tian; Jiang, Shuo; Zhang, Jing; Weng, Qiqing; Yu, Yang; Li, Haonan; Ding, Xin; Yang, Yiqi; Wang, Weixuan; Wang, Lexun; Luo, Duosheng; Xiao, Xue; Piao, Shenghua; Zhu, Qing; Rong, Xianglu; Guo, Jiao] Minist Educ, Key Lab Glucolipid Metab Disorder, Guangzhou, Peoples R China.
   [Lan, Tian; Jiang, Shuo; Zhang, Jing; Weng, Qiqing; Yu, Yang; Li, Haonan; Ding, Xin; Yang, Yiqi; Wang, Weixuan; Wang, Lexun; Luo, Duosheng; Xiao, Xue; Piao, Shenghua; Zhu, Qing; Rong, Xianglu; Guo, Jiao] Guangdong TCM Key Lab Metab Dis, Guangzhou, Peoples R China.
   [Tian, Song; Hu, Sha] Wuhan Univ, Renmin Hosp, Dept Cardiol, Wuhan, Peoples R China.
C3 Guangdong Pharmaceutical University; Ministry of Education - China;
   Wuhan University
RP Guo, J (corresponding author), Guangdong Pharmaceut Univ, Guangzhou Higher Educ Mega Ctr, 280 Wai Huan Dong Rd, Guangzhou 510006, Peoples R China.
EM gyguoyz@163.com
RI weng, qi/KHC-8473-2024; Li, Haonan/IQV-4567-2023; Bei,
   Weijian/K-5208-2015; Tian, Song/HJI-2076-2023
FU Special Topics of General Projects of Guangzhou Science and Technology
   Plan of China [201904010075]; Major Basic and Applied Basic Research
   Projects in Guangdong Province of China [2019B030302005]; National
   Natural Science Foundation of China [81830113, 81870420, 82070590];
   National Key R&D Plan of China "Research on Modernization of Traditional
   Chinese Medicine" program [2018YFC1704200]
FX The Special Topics of General Projects of Guangzhou Science and
   Technology Plan of China, Grant/Award Number: 201904010075; the Major
   Basic and Applied Basic Research Projects in Guangdong Province of
   China, Grant/Award Number: 2019B030302005; the National Natural Science
   Foundation of China, Grant/Award Number: 81830113, 81870420 and
   82070590; the National Key R&D Plan of China "Research on Modernization
   of Traditional Chinese Medicine" program, Grant/Award Number:
   2018YFC1704200
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NR 44
TC 66
Z9 70
U1 12
U2 121
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0270-9139
EI 1527-3350
J9 HEPATOLOGY
JI Hepatology
PD JUL
PY 2022
VL 76
IS 1
BP 155
EP 171
DI 10.1002/hep.32221
EA DEC 2021
PG 17
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 2E9RF
UT WOS:000731418900001
PM 34717002
OA Green Published, hybrid
DA 2025-06-11
ER

EF﻿FN Clarivate Analytics Web of Science
VR 1.0
PT J
AU Wu, M
   Li, YB
   Yang, Y
   Wang, CC
   Jiang, LJ
   Tong, X
   Xu, WM
   Chen, NJ
   Hu, JQ
AF Wu, Meng
   Li, Yu-Bo
   Yang, Yan
   Wang, Chuan-Chi
   Jiang, Li-Jie
   Tong, Xu
   Xu, Wei-Ming
   Chen, Nan-Jie
   Hu, Jing-Qing
TI The Influencing Factors and Traditional Chinese Medicine Syndrome
   Characteristics of Depression/Anxiety in Patients with Coronary Heart
   Disease: A Cross-Sectional Study
SO WORLD JOURNAL OF TRADITIONAL CHINESE MEDICINE
LA English
DT Article
DE Anxiety; coronary heart disease; depression; phlegm and stasis syndrome;
   traditional Chinese medicine syndrome
ID METAANALYSIS; ASSOCIATION
AB Objective:The objective of the study was to investigate the situation of depression/anxiety in patients with coronary heart disease (CHD) at different stages of the disease and to analyze the influencing factors and the evolution characteristics of traditional Chinese medicine (TCM) syndromes.Materials and Methods:From October 2016 to April 2018, a cross-sectional survey was conducted at 48 clinical research centers in 23 provinces, cities, and autonomous regions across China. A total of 11383 cases were collected by outpatient or inpatient cases, including healthy individuals (n = 1754), low-risk individuals (n = 2339), metabolic syndrome (n = 1475), stable CHD (n = 3366), acute coronary syndrome (n = 704), perioperative intervention treatment (n = 753), and heart failure (n = 992). Survey demographic data, lifestyle habits, disease and health status, TCM symptoms and signs, and other information were collected.Results:The prevalence rates of depression/anxiety in surveyed patients with CHD were 35.7% and 21.0%, respectively, and were higher than those in patients with metabolic syndrome (18.8% and 10.3%, respectively), low-risk individuals (11.7% and 7.5%), and healthy individuals (9.7% and 5.7%, respectively). The significant risk factors for CHD combined with depression analyzed by the generalized linear mixed model included age (odds ratio [OR] = 0.019), gender (OR = 0.632), hypertension (OR = 0.306), course of CHD (OR = 0.022), stent placement (OR = -0.284), heart function level (OR = -4.151/-3.336/-2.118), and phlegm stasis syndrome score (OR = 0.129). The significant risk factors for CHD combined with anxiety included gender (OR = 0.581), heart function level (OR = -1.856), and phlegm stasis syndrome score (OR = 0.094). Factor analysis was conducted on the symptoms and signs of patients with CHD combined with depression/anxiety, and 16 common factors were obtained with cumulative contribution rates of 62.83% and 66.13%, respectively. Disease syndromes included liver and kidney deficiency syndrome, liver stagnation and discomfort syndrome, Qi deficiency syndrome, liver meridian fire heat syndrome, kidney deficiency syndrome, phlegm dampness syndrome, heart and gallbladder Qi deficiency syndrome, blood stasis syndrome, lung Qi inversion syndrome, Yang deficiency syndrome, and three symptoms named diseases, including chest tightness, chest pain, insomnia, and head discomfort.Conclusions:Through cross-sectional design, the data obtained in this study revealed the actual situation of CHD patients with anxiety or depression at different stages. The influencing factors of CHD patients with depression or anxiety were analyzed through the collected cross-sectional information and further revealed the syndromic characteristics of CHD patients with depression or anxiety at different stages from the perspective of TCM syndromes. The data obtained provide a practical basis for further understanding the clinical characteristics of bicardiac diseases and for proposing treatment strategies in stages.
C1 [Wu, Meng; Li, Yu-Bo; Jiang, Li-Jie; Tong, Xu] China Acad Chinese Med Sci, Inst Basic Theory Chinese Med, Beijing, Peoples R China.
   [Yang, Yan; Wang, Chuan-Chi; Xu, Wei-Ming] China Sci & Technol Dev Ctr Chinese Med, Beijing, Peoples R China.
   [Chen, Nan-Jie] Beijing Univ Aeronaut & Astronaut, Beijing, Peoples R China.
C3 China Academy of Chinese Medical Sciences; Institute of Basic Theory for
   Chinese Medicine, CACMS; Beihang University
RP Hu, JQ (corresponding author), Tianjin Univ Tradit Chinese Med, Tianjin, Peoples R China.
EM gcp306@126.com
RI Xu, Weiming/JMQ-6528-2023; Jiang, Lijie/LLM-5934-2024; Li,
   Yubo/MFH-4301-2025
FU National Key Basic Research and Development Program ("973" Program)
   [2014CB542903]; National Key Research and Development Plan
   [2019YFC1708501]; National Nature Science Foundation [81673845]
FX The study was supported by funds from the National Key Basic Research
   and Development Program ("973" Program) (2014CB542903), National Key
   Research and Development Plan (2019YFC1708501), and National Nature
   Science Foundation (81673845).
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NR 35
TC 0
Z9 0
U1 1
U2 1
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, Maharashtra, INDIA
SN 2311-8571
EI 2589-2894
J9 WORLD J TRAD CHINESE
JI World J. Trad. Chinese Med.
PD JAN-MAR
PY 2025
VL 11
IS 1
BP 90
EP 100
DI 10.4103/wjtcm.wjtcm_81_24
PG 11
WC Integrative & Complementary Medicine; Medicine, Research & Experimental;
   Pharmacology & Pharmacy
WE Emerging Sources Citation Index (ESCI)
SC Integrative & Complementary Medicine; Research & Experimental Medicine;
   Pharmacology & Pharmacy
GA Y7A7R
UT WOS:001433611600003
OA gold
DA 2025-06-11
ER

PT J
AU Vreijling, SR
   Penninx, BWJH
   Verhoeven, JE
   Teunissen, CE
   Blujdea, ER
   Beekman, ATF
   Lamers, F
   Jansen, R
AF Vreijling, Sarah R.
   Penninx, Brenda W. J. H.
   Verhoeven, Josine E.
   Teunissen, Charlotte E.
   Blujdea, Elena R.
   Beekman, Aartjan T. F.
   Lamers, Femke
   Jansen, Rick
TI Running therapy or antidepressants as treatments for immunometabolic
   depression in patients with depressive and anxiety disorders: A
   secondary analysis of the MOTAR study
SO BRAIN BEHAVIOR AND IMMUNITY
LA English
DT Article
DE Depression; Exercise; Running therapy; Antidepressants; Inflammation;
   Metabolism
ID INSULIN SENSITIVITY; EXERCISE; HOMEOSTASIS; PREDICTOR; OUTCOMES
AB Background: Exercise promotes immunometabolic health and is increasingly recognized as an effective depression treatment. Exercise may be beneficial for patients with immunometabolic depression (IMD), who experience inflammatory and metabolic dysregulations and may respond less to antidepressants. This secondary analysis of the MOTAR study compared the effects of running therapy and antidepressants on IMD features among patients with depression and/or anxiety disorder. We additionally assessed whether baseline IMD moderated intervention effects on depression. Methods: Participants received 16 weeks of group-based running therapy (N = 96) or escitalopram/sertraline (N = 45) in a partially randomized patient preference design. IMD features included atypical, energy-related symptom (AES) severity, inflammation index (CRP, IFN-gamma, IL-6, TNF-alpha), metabolic syndrome index, three metabolite principle components (PC) (derived from 73 metabolites) and a composite IMD index. Results: Interventions differed in changes in the metabolic syndrome index (d = 0.59, p = 0.026) and IMD index (d = 0.85, p < 0.001). While running therapy decreased both outcomes, the antidepressant group showed an increased IMD index. Although groups did not differ statistically significant in changes in AES severity, inflammation index, and metabolite PC1, results indicated a consistent trend towards greater improvement with running therapy across these outcomes as well (d = 0.38 to 0.52). Baseline IMD did not moderate intervention effects on depression outcomes. Conclusions: This study suggests that exercise more effectively targets the IMD dimension than antidepressants. Patients with IMD did not benefit more from running therapy than antidepressants in terms of reductions in depression. Exercise should be considered an alternative or complementary treatment to particularly reduce IMD features in depressed patients.
C1 [Vreijling, Sarah R.; Penninx, Brenda W. J. H.; Verhoeven, Josine E.; Beekman, Aartjan T. F.; Lamers, Femke; Jansen, Rick] Amsterdam UMC Locat Vrije Univ Amsterdam, Dept Psychiat, NL-1117 Amsterdam, Netherlands.
   [Vreijling, Sarah R.; Penninx, Brenda W. J. H.; Verhoeven, Josine E.; Beekman, Aartjan T. F.; Lamers, Femke; Jansen, Rick] Mental Hlth Program, Amsterdam Publ Hlth, Amsterdam, Netherlands.
   [Penninx, Brenda W. J. H.; Beekman, Aartjan T. F.; Jansen, Rick] Amsterdam Neurosci, Mood Anxiety Psychosis Sleep & Stress program, Amsterdam, Netherlands.
   [Verhoeven, Josine E.; Beekman, Aartjan T. F.] GGZ inGeest Mental Hlth Care, Amsterdam, Netherlands.
   [Teunissen, Charlotte E.; Blujdea, Elena R.] Vrije Univ Amsterdam, Dept Lab Med, Neurochem Lab, Amsterdam UMC,Amsterdam Neurosci, Amsterdam, Netherlands.
C3 Vrije Universiteit Amsterdam; University of Amsterdam; Vrije
   Universiteit Amsterdam
RP Vreijling, SR (corresponding author), Vrije Univ Amsterdam, Dept Psychiat, Amsterdam UMC, Oldenaller 1, NL-1081 HJ Amsterdam, Netherlands.
EM s.r.vreijling@amsterdamumc.nl
RI Lamers, Femke/G-5161-2012; Penninx, Brenda/S-7627-2017; Jansen,
   Ritsert/C-1160-2013; Beekman, Aartjan T./LUZ-6919-2024
OI Vreijling, Sarah Rosa/0000-0002-4667-687X; Blujdea, Elena
   Raluca/0009-0001-7305-2122
FU ZonMw: The Netherlands Organization for Health Research and Development
   [636310017]; Netherlands Organisation for Health Research and
   Development (VICI) [91811602]; VU University Medical Center
FX Funding for this work was provided by ZonMw: The Netherlands
   Organization for Health Research and Development (project number:
   636310017, research programme GGZ) obtained by Dr. ir. F. Lamers and Dr.
   R. Jansen. The MOTAR study (https:// www.motar.nl) has been funded
   through the Netherlands Organisation for Health Research and Development
   (VICI grant number 91811602) and funds from VU University Medical Center
   and GGZ inGeest by prof. Dr. B.W.J. H. Penninx. The funders had no role
   in the study design, in the collection, analysis and interpretation of
   data, the writing of the report and in the decision to submit the
   article for publication.
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NR 35
TC 1
Z9 1
U1 7
U2 11
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0889-1591
EI 1090-2139
J9 BRAIN BEHAV IMMUN
JI Brain Behav. Immun.
PD JAN
PY 2025
VL 123
BP 876
EP 883
DI 10.1016/j.bbi.2024.10.033
EA NOV 2024
PG 8
WC Immunology; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Neurosciences & Neurology; Psychiatry
GA M0B8J
UT WOS:001354292000001
PM 39477079
OA hybrid
DA 2025-06-11
ER

PT J
AU Farr, SA
   Yamada, KA
   Butterfield, DA
   Abdul, HM
   Xu, L
   Miller, NE
   Banks, WA
   Morley, JE
AF Farr, Susan A.
   Yamada, Kelvin A.
   Butterfield, D. Allan
   Abdul, H. Mohammad
   Xu, Lin
   Miller, Nicole E.
   Banks, William A.
   Morley, John E.
TI Obesity and Hypertriglyceridemia produce cognitive impairment
SO ENDOCRINOLOGY
LA English
DT Article
ID LONG-TERM POTENTIATION; HIPPOCAMPAL SYNAPTIC-TRANSMISSION; OREXIN-A;
   MEMORY PERFORMANCE; OXIDATIVE STRESS; NITRIC-OXIDE; LEPTIN; DEMENTIA;
   PROTEIN; BRAIN
AB Obesity is associated with cognitive impairments. Long-term mechanisms for this association include consequences of hyperglycemia, dyslipidemia, or other factors comprising metabolic syndrome X. We found that hypertriglyceridemia, the main dyslipidemia of metabolic syndrome X, is in part responsible for the leptin resistance seen in obesity. Here we determined whether triglycerides have an immediate and direct effect on cognition. Obese mice showed impaired acquisition in three different cognitive paradigms: the active avoidance T-maze, the Morris water maze, and a food reward lever press. These impairments were not attributable to differences in foot shock sensitivity, swim speed, swimming distance, or voluntary milk consumption. Impaired cognition in obese mice was improved by selectively lowering triglycerides with gemfibrozil. Injection into the brain of the triglyceride triolein, but not of the free fatty acid palmitate, impaired acquisition in normal body weight mice. Triolein or milk (97% of fats are triglycerides), but not skim milk ( no triglycerides), impaired maintenance of the N-methyl-D-aspartate component of the hippocampal long-term synaptic potential. Measures of oxidative stress in whole brain were reduced by gemfibrozil. We conclude that triglycerides mediate cognitive impairment as seen in obesity, possibly by impairing maintenance of the N-methyl-D-aspartate component of hippocampal long-term potentiation, and that lowering triglycerides can reverse the cognitive impairment and improve oxidative stress in the brain.
C1 [Farr, Susan A.; Miller, Nicole E.; Banks, William A.; Morley, John E.] Vet Affairs Med Ctr, Ctr Geriatr Res Educ & Clin, St Louis, MO 63106 USA.
   [Farr, Susan A.; Miller, Nicole E.; Banks, William A.; Morley, John E.] St Louis Univ, Sch Med, Div Geriatr Med, St Louis, MO 63104 USA.
   [Yamada, Kelvin A.; Xu, Lin] Washington Univ, Sch Med, Dept Neurol, St Louis, MO 63110 USA.
   [Butterfield, D. Allan; Abdul, H. Mohammad] Univ Kentucky, Dept Chem, Lexington, KY 40536 USA.
   [Butterfield, D. Allan; Abdul, H. Mohammad] Univ Kentucky, Ctr Membrane Sci, Lexington, KY 40536 USA.
C3 Geriatric Research Education & Clinical Center; US Department of
   Veterans Affairs; Veterans Health Administration (VHA); Saint Louis
   University; Washington University (WUSTL); University of Kentucky;
   University of Kentucky
RP Banks, WA (corresponding author), Vet Affairs Med Ctr, Ctr Geriatr Res Educ & Clin, 915 N Grand Blvd, St Louis, MO 63106 USA.
EM bankswa@slu.edu
RI Banks, William/K-1330-2017; Miller-Struttmann, Nicole/AAZ-1535-2020;
   Morley, John/K-1570-2019; Xu, Lin/C-4662-2011
OI Farr, Susan/0000-0002-0481-2570; Miller-Struttmann,
   Nicole/0000-0002-4799-4802
FU PHS HHS [42774, 051334] Funding Source: Medline
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NR 37
TC 308
Z9 348
U1 1
U2 27
PU ENDOCRINE SOC
PI CHEVY CHASE
PA 8401 CONNECTICUT AVE, SUITE 900, CHEVY CHASE, MD 20815-5817 USA
SN 0013-7227
J9 ENDOCRINOLOGY
JI Endocrinology
PD MAY
PY 2008
VL 149
IS 5
BP 2628
EP 2636
DI 10.1210/en.2007-1722
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 291LX
UT WOS:000255200000064
PM 18276751
OA Green Published
DA 2025-06-11
ER

PT J
AU Vermeltfoort, IAC
   Raijmakers, PGHM
   Odekerken, DAM
   Kuijper, AFM
   Zwijnenburg, A
   Teule, GJJ
AF Vermeltfoort, I. A. C.
   Raijmakers, P. G. H. M.
   Odekerken, D. A. M.
   Kuijper, A. F. M.
   Zwijnenburg, A.
   Teule, G. J. J.
TI Association between anxiety disorder and the extent of ischemia observed
   in cardiac syndrome X
SO JOURNAL OF NUCLEAR CARDIOLOGY
LA English
DT Article
DE Myocardial perfusion imaging; SPECT; coronary artery disease; ischemia;
   myocardial
ID CARDIOVASCULAR MAGNETIC-RESONANCE; TYPICAL CHEST-PAIN;
   MYOCARDIAL-PERFUSION; MENTAL STRESS; CORONARY ARTERIOGRAMS;
   ANGINA-PECTORIS; WOMEN; DYSFUNCTION; RESPONSES; EXERCISE
AB A possible link between the heart and brain has been reported for cardiac syndrome X. Anxiety disorder could be a pathophysiological mechanism for this cardiac chest pain. To the authors' knowledge, a quantitative analysis correlating anxiety with the extent of ischemia has not been done.
   In this pilot study, we evaluated 20 patients with typical chest pain and completely normal coronary angiograms. These patients were screened with the State Scale and Trait Scale of the State-Trait Anxiety Inventory (STAI). All patients underwent myocardial perfusion scintigraphic imaging. The scintigrams were scored by three experienced readers having no knowledge of the STAI screening results. Patients with a low trait anxiety had significantly less ischemic segments on the myocardial perfusion imaging than patients with a high trait anxiety (1.8 +/- A 1.9 vs 3.5 +/- A 0.6, P < .05). For state anxiety, no significant differences could be found.
   Cardiac syndrome X patients with high trait anxiety are at risk of having more ischemia.
C1 [Vermeltfoort, I. A. C.; Raijmakers, P. G. H. M.] Vrije Univ Amsterdam Med Ctr, Dept Nucl Med, NL-1007 MB Amsterdam, Netherlands.
   [Vermeltfoort, I. A. C.; Raijmakers, P. G. H. M.] Vrije Univ Amsterdam Med Ctr, PET Res, NL-1007 MB Amsterdam, Netherlands.
   [Zwijnenburg, A.] Spaarne Hosp, Dept Nucl Med, Hoofddorp, Netherlands.
   [Odekerken, D. A. M.; Kuijper, A. F. M.] Spaarne Hosp, Dept Cardiol, Hoofddorp, Netherlands.
   [Teule, G. J. J.] Maastricht Univ, Med Ctr, Dept Nucl Med, Maastricht, Netherlands.
   [Teule, G. J. J.] Maastricht Univ, Med Ctr, PET Res, Maastricht, Netherlands.
C3 Vrije Universiteit Amsterdam; VU UNIVERSITY MEDICAL CENTER; Vrije
   Universiteit Amsterdam; VU UNIVERSITY MEDICAL CENTER; Spaarne Hospital;
   Spaarne Hospital; Maastricht University; Maastricht University
RP Vermeltfoort, IAC (corresponding author), Vrije Univ Amsterdam Med Ctr, Dept Nucl Med, Boelelaan 1117, NL-1007 MB Amsterdam, Netherlands.
EM i.vermeltfoort@vumc.nl
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NR 36
TC 16
Z9 17
U1 0
U2 2
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1071-3581
EI 1532-6551
J9 J NUCL CARDIOL
JI J. Nucl. Cardiol.
PD JUN
PY 2009
VL 16
IS 3
BP 405
EP 410
DI 10.1007/s12350-008-9032-2
PG 6
WC Cardiac & Cardiovascular Systems; Radiology, Nuclear Medicine & Medical
   Imaging
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Radiology, Nuclear Medicine &
   Medical Imaging
GA 445KL
UT WOS:000266049600013
PM 19156475
OA hybrid
DA 2025-06-11
ER

PT J
AU Zhou, LN
   Ma, XC
   Wang, W
AF Zhou, Li-Na
   Ma, Xian-Cang
   Wang, Wei
TI Incidence and risk factors of depression in patients with metabolic
   syndrome
SO WORLD JOURNAL OF PSYCHIATRY
LA English
DT Article
DE Depression; Metabolic syndrome; Prevalence; Risk factor
ID CHRONIC DISEASES; CHINA HEALTH; OLDER-ADULTS; SHORT-FORM; ASSOCIATION;
   SYMPTOMS; INFLAMMATION; POPULATION; PREVALENCE; ANXIETY
AB BACKGROUND Many studies have explored the relationship between depression and metabolic syndrome (MetS), especially in older people. China has entered an aging society. However, there are still few studies on the elderly in Chinese communities. AIM To investigate the incidence and risk factors of depression in MetS patients in mainland China and to construct a predictive model. METHODS Data from four waves of the China Health and Retirement Longitudinal Study were selected, and middle-aged and elderly patients with MetS (n = 2533) were included based on the first wave. According to the center for epidemiological survey-depression scale (CESD), participants with MetS were divided into depression (n = 938) and non-depression groups (n = 1595), and factors related to depression were screened out. Subsequently, the 2-, 4-, and 7-year follow-up data were analyzed, and a prediction model for depression in MetS patients was constructed. RESULTS The prevalence of depression in middle-aged and elderly patients with MetS was 37.02%. The prevalence of depression at the 2-, 4-, and 7-year follow-up was 29.55%, 34.53%, and 38.15%, respectively. The prediction model, constructed using baseline CESD and Physical Self-Maintenance Scale scores, average sleep duration, number of chronic diseases, age, and weight had a good predictive effect on the risk of depression in MetS patients at the 2-year follow-up (area under the curve = 0.775, 95% confidence interval: 0.750-0.800, P < 0.001), with a sensitivity of 68% and a specificity of 74%. CONCLUSION The prevalence of depression in middle-aged and elderly patients with MetS has increased over time. The early identification of and intervention for depressive symptoms requires greater attention in MetS patients.
C1 [Zhou, Li-Na; Ma, Xian-Cang; Wang, Wei] Xi An Jiao Tong Univ, Affiliated Hosp 1, Dept Psychiat, 277 West Yanta Rd, Xian 710061, Shaanxi, Peoples R China.
C3 Xi'an Jiaotong University
RP Wang, W (corresponding author), Xi An Jiao Tong Univ, Affiliated Hosp 1, Dept Psychiat, 277 West Yanta Rd, Xian 710061, Shaanxi, Peoples R China.
EM xianwv@sina.com
RI wang, yanhui/HPG-3348-2023
FU Shaanxi Provincial Key Research and Development Program [2023-YBSF-517];
   National Natural Science Foundation of China [82301737]
FX Supported by Shaanxi Provincial Key Research and Development Program,
   No. 2023-YBSF-517; and National Natural Science Foundation of China, No.
   82301737.
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NR 41
TC 3
Z9 3
U1 3
U2 8
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 7041 Koll Center Parkway, Suite 160, PLEASANTON, CA, UNITED STATES
SN 2220-3206
J9 WORLD J PSYCHIATR
JI World J. Psychiatr.
PD FEB 19
PY 2024
VL 14
IS 2
DI 10.5498/wjp.v14.i2.245
PG 11
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychiatry
GA LB6U4
UT WOS:001184365100012
PM 38464768
OA gold, Green Accepted
DA 2025-06-11
ER

PT J
AU Bränn, E
   Malavaki, C
   Fransson, E
   Ioannidi, MK
   Henriksson, HE
   Papadopoulos, FC
   Chrousos, GP
   Klapa, M
   Skalkidou, A
AF Brann, Emma
   Malavaki, Christina
   Fransson, Emma
   Ioannidi, Maria-Konstantina
   Henriksson, Hanna E.
   Papadopoulos, Fotios C.
   Chrousos, George P.
   Klapa, Maria, I
   Skalkidou, Alkistis
TI Metabolic Profiling Indicates Diversity in the Metabolic Physiologies
   Associated With Maternal Postpartum Depressive Symptoms
SO FRONTIERS IN PSYCHIATRY
LA English
DT Article
DE postpartum depression; metabolomics; perinatal depression; pregnancy;
   GC-MS metabolic profiling; molecular psychiatry; precision medicine
ID PERINATAL DEPRESSION; AMINOMALONIC ACID; OXIDATIVE STRESS;
   BLOOD-PRESSURE; BODY-FAT; PREGNANCY; IDENTIFICATION; ANXIETY; WOMEN;
   ALLOPREGNANOLONE
AB Background: Postpartum depression (PPD) is a devastating disease requiring improvements in diagnosis and prevention. Blood metabolomics identifies biological markers discriminatory between women with and those without antenatal depressive symptoms. Whether this cutting-edge method can be applied to postpartum depressive symptoms merits further investigation. Methods: As a substudy within the Biology, Affect, Stress, Imagine and Cognition Study, 24 women with PPD symptom (PPDS) assessment at 6 weeks postpartum were included. Controls were selected as having a score of <= 6 and PPDS cases as >= 12 on the Edinburgh Postnatal Depression Scale. Blood plasma was collected at 10 weeks postpartum and analyzed with gas chromatography-mass spectrometry metabolomics. Results: Variations of metabolomic profiles within the PPDS samples were identified. One cluster showed altered kidney function, whereas the other, a metabolic syndrome profile, both previously associated with depression. Five metabolites (glycerol, threonine, 2-hydroxybutanoic acid, erythritol, and phenylalanine) showed higher abundance among women with PPDSs, indicating perturbations in the serine/threonine and glycerol lipid metabolism, suggesting oxidative stress conditions. Conclusions: Alterations in certain metabolites were associated with depressive pathophysiology postpartum, whereas diversity in PPDS physiologies was revealed. Hence, plasma metabolic profiling could be considered in diagnosis and pathophysiological investigation of PPD toward providing clues for treatment. Future studies require standardization of various subgroups with respect to symptom onset, lifestyle, and comorbidities.
C1 [Brann, Emma; Fransson, Emma; Henriksson, Hanna E.; Skalkidou, Alkistis] Uppsala Univ, Dept Womens & Childrens Hlth, Uppsala, Sweden.
   [Malavaki, Christina; Ioannidi, Maria-Konstantina; Klapa, Maria, I] Fdn Res & Technol Hellas, Inst Chem Engn Sci, Metab Engn & Syst Biol Lab, Patras, Greece.
   [Fransson, Emma] Karolinska Inst, Ctr Translat Microbiome Res, Dept Microbiol Tumor & Cell Biol, Stockholm, Sweden.
   [Ioannidi, Maria-Konstantina] Univ Patras, Dept Biol, Patras, Greece.
   [Papadopoulos, Fotios C.] Uppsala Univ, Dept Neurosci, Psychiat, Uppsala, Sweden.
   [Chrousos, George P.] Natl & Kapodistrian Univ Athens, Univ Res Inst Maternal & Child Hlth & Precis Med, Med Sch, UNESCO Chair Adolescent Hlth Care, Athens, Greece.
C3 Uppsala University; Foundation for Research & Technology - Hellas
   (FORTH); Institute of Chemical Engineering Sciences (ICE-HT); Karolinska
   Institutet; University of Patras; Uppsala University; National &
   Kapodistrian University of Athens
RP Skalkidou, A (corresponding author), Uppsala Univ, Dept Womens & Childrens Hlth, Uppsala, Sweden.; Klapa, M (corresponding author), Fdn Res & Technol Hellas, Inst Chem Engn Sci, Metab Engn & Syst Biol Lab, Patras, Greece.
EM alkistis.skalkidou@kbh.uu.se
RI Chrousos, George/G-8702-2011; KLAPA, MARIA/ITT-8426-2023; Fransson,
   Emma/A-9016-2012; Skalkidou, Alkistis/JBR-9089-2023; Papadopoulos,
   Fotios/H-1319-2019; Skalkidou, Alkistis/C-1521-2015
OI Skalkidou, Alkistis/0000-0002-4935-7532; Ioannidi,
   Maria-Konstantina/0000-0001-7914-8363
FU Swedish Research Foundation [VR: 521-2013-2339/523-2014-2342]; Greek
   NSRF [MIS 5002550, MIS 5028091, MIS 5002469, MIS 5002780]; Marianne and
   Marcus Wallenberg Foundation [MMW2011.0115]; ALF-grants Region Uppsala
   [Skalkidou-ALF-2020]; Swedish Medical Association [SLS-250581]
FX Sources of funding were (a) the Swedish Research Foundation projects VR:
   521-2013-2339/523-2014-2342; (b) the Greek NSRF 2014-2020 projects
   INSPIRED (MIS 5002550), EATRISGR (MIS 5028091), BITAD (MIS 5002469) and
   ELIXIR-GR (MIS 5002780; (c) the Marianne and Marcus Wallenberg
   Foundation (MMW2011.0115), (d) the ALF-grants Region Uppsala
   (Skalkidou-ALF-2020), and (e) the Swedish Medical Association
   (SLS-250581).
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NR 81
TC 15
Z9 15
U1 2
U2 25
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-0640
J9 FRONT PSYCHIATRY
JI Front. Psychiatry
PD JUN 25
PY 2021
VL 12
AR 685656
DI 10.3389/fpsyt.2021.685656
PG 10
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA TG3GI
UT WOS:000671296100001
PM 34248718
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Farmanfarma, KK
   Kaykhaei, MA
   Mohammadi, M
   Adineh, HA
   Ansari-Moghaddam, A
AF Farmanfarma, Khadijeh Kalan
   Kaykhaei, Mahmoud Ali
   Mohammadi, Mehdi
   Adineh, Hosein Ali
   Ansari-Moghaddam, Alireza
TI Metabolic syndrome and chronic diseases in Iran; A case control
   meta-analysis
SO ARCHIVES OF PHARMACY PRACTICE
LA English
DT Review
DE Metabolic Syndrome; Prevalence; Chronic disease
ID POLYCYSTIC-OVARY-SYNDROME; TYPE-2 DIABETIC-PATIENTS;
   CORONARY-HEART-DISEASE; INSULIN-RESISTANCE; CARDIOVASCULAR RISK;
   PREVALENCE; ASSOCIATION; WOMEN; COMPONENTS; ABNORMALITIES
AB Background: To quantify the frequency of metabolic syndrome amongst individuals suffering from some chronic diseases and to compare them with the data obtained from healthy population. Methods: Manuscripts published on the prevalence of metabolic syndrome between 2000 and 2016 were identified through the following databases: Magiran. SID. and Iran Medex as well as PUBMED. EMBASE. MEDLINE, Web of Science, Scopus, and Google scholar using related MESH terms. Studies included if they had published quantitative estimates and measure of variability and/or confidence limits in the individual with the following diseases: diabetes, cardiovascular disease. cancer. periodontal. arthritis. polycystic ovary syndrome, Non-alcoholic fatty liver, psychiatric disorder, kidney and chronic disease. Data were analyzed with Stata, version 11. Results: A total of 62 articles selected for the final stage of this meta-analysis. The pooled prevalence of metabolic syndrome among diabetes, those with cardiovascular diseases. cases with renal failure, patients with NAFLD. periodontal subjects and individuals by arthritis were significantly higher than healthy population (P < 0.05). The risk of aforementioned diseases was found to be two to six tunes higher in those with metabolic syndrome than tic normal population. Comparably, there was all inverse association between metabolic syndrome and mental disorders. Conclusions: Our findings suggest the early recognition, control and prevention of the metabolic syndrome and its individual components in the general population.
C1 [Farmanfarma, Khadijeh Kalan; Kaykhaei, Mahmoud Ali; Mohammadi, Mehdi; Ansari-Moghaddam, Alireza] Zahedan Univ Med Sci, Hlth Promot Res Ctr, Dept Epidemiol & Biostat, Zahedan, Iran.
   [Adineh, Hosein Ali] Iranshahr Univ Med Sci, Sch Hlth, Dept Epidemiol & Biostat, Iranshahr, Iran.
C3 Zahedan University of Medical Sciences
RP Ansari-Moghaddam, A (corresponding author), Zahedan Univ Med Sci, Hlth Promot Res Ctr, Dept Epidemiol & Biostat, Zahedan, Iran.
EM aansarimoghaddam2@gmail.com
RI Adineh, Hossein/C-4676-2016; Ansari-Moghaddam, Alireza/J-2406-2017;
   Kaykhaei, Mahmoud Ali/F-8801-2011
OI Kaykhaei, Mahmoud Ali/0000-0003-2994-4243
FU Zahedan University of Medical Sciences [8140]; Health Promotion Research
   Center; Zahedan University of Medical Sciences
FX This manuscript is a part of Ph.D. thesis from Khadijeh Kalan
   FarmanFarma who has been funded by a scholarship from Zahedan University
   of Medical Sciences (Grant no.: 8140). Therefore, authors would like to
   express their appreciation to the Health Promotion Research Center and
   Zahedan University of Medical Sciences for their support
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NR 91
TC 0
Z9 0
U1 0
U2 15
PU ARCHIVES GLOBAL PROFESSIONALS
PI KARACHI
PA ARCHIVES GLOBAL PROFESSIONALS, KARACHI, PAKISTAN
SN 2320-5210
EI 2045-080X
J9 ARCH PHARM PRACT
JI Arch. Pharm. Pract.
PD APR-JUN
PY 2020
VL 11
IS 2
BP 113
EP 123
PG 11
WC Pharmacology & Pharmacy
WE Emerging Sources Citation Index (ESCI)
SC Pharmacology & Pharmacy
GA OO4CN
UT WOS:000587328800017
DA 2025-06-11
ER

PT J
AU Di Prinzio, RR
   Arnesano, G
   Meraglia, I
   Magnavita, N
AF Di Prinzio, Reparata Rosa
   Arnesano, Gabriele
   Meraglia, Igor
   Magnavita, Nicola
TI Headache in Workers: A Matched Case-Control Study
SO EUROPEAN JOURNAL OF INVESTIGATION IN HEALTH PSYCHOLOGY AND EDUCATION
LA English
DT Article
DE anxiety; depression; sleep; aggression; diet; cholesterol; blood
   pressure; glycemia; stress; lifestyle
ID SLEEP QUALITY INDEX; METABOLIC SYNDROME; MIGRAINE HEADACHE; GLOBAL
   BURDEN; RISK-FACTORS; HEALTH-CARE; DISABILITY; ASSOCIATION; PREVALENCE;
   EPIDEMIOLOGY
AB A case-control study including 446 workers reporting headaches (cases; 136 males and 310 females, mean age 46.71 +/- 10.84 years) and 446 age- and sex-matched colleagues without headaches (controls; mean age 45.44 +/- 10.13) was conducted in the second half of 2020 in a sample drawn from socio health and commercial services companies to investigate the association of headache with lifestyle, metabolic, and work-related factors. Workers suffering from headache reported higher body weight (OR: 1.92, 95% CI: 1.46-2.53, p < 0.001), higher blood cholesterol (OR: 2.01, 95% CI: 1.46-2.77, p < 0.001), triglyceride (OR: 2.01, 95% CI: 1.20-3.35, p < 0.01), blood glucose (OR: 1.91, 95% CI: 1.16-3.24, p < 0.01), and blood pressure levels (OR: 1.76, 95% CI: 1.23-2.52, p < 0.01). In the year preceding the survey, cases had experienced a higher frequency of workplace violence (OR: 2.29, 95% CI: 1.25-4.20, p < 0.01 for physical aggression, OR: 2.22, 95% CI: 1.45-3.41, p < 0.001 for threat, OR: 2.74, 95% CI: 1.72-4.38, p < 0.001 for harassment) and were more frequently distressed (effort/reward ratio > 1) (OR: 1.82, 95% CI: 1.39-2.40, p < 0.001) than the controls. Compared to the controls, cases also had higher scores on anxiety and depression scales, lower scores on happiness, and lower levels of sleep quality (p < 0.001). The association of headaches with metabolic and mental health problems suggests that monitoring headaches in the workplace could help to identify workers at risk of impairment.
C1 [Di Prinzio, Reparata Rosa] Univ Cattolica Sacro Cuore, Fac Med & Chirurg, Postgrad Sch Hlth Econ & Management, Hlth Syst & Serv Res, I-00168 Rome, Italy.
   [Di Prinzio, Reparata Rosa] Bambino Gesu Childrens Hosp IRCCS, Occupat Med Unit, I-00165 Rome, Italy.
   [Arnesano, Gabriele; Meraglia, Igor; Magnavita, Nicola] Univ Cattolica Sacro Cuore, Fac Med & Chirurg, Postgrad Sch Occupat Hlth, Dept Life Sci & Publ Hlth, I-00168 Rome, Italy.
   [Magnavita, Nicola] Fdn Policlin Univ Agostino Gemelli IRCCS, Dept Sci Woman Child & Publ Hlth, I-00168 Rome, Italy.
C3 Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli;
   IRCCS Bambino Gesu; Catholic University of the Sacred Heart; IRCCS
   Policlinico Gemelli; Catholic University of the Sacred Heart; IRCCS
   Policlinico Gemelli
RP Magnavita, N (corresponding author), Univ Cattolica Sacro Cuore, Fac Med & Chirurg, Postgrad Sch Occupat Hlth, Dept Life Sci & Publ Hlth, I-00168 Rome, Italy.; Magnavita, N (corresponding author), Fdn Policlin Univ Agostino Gemelli IRCCS, Dept Sci Woman Child & Publ Hlth, I-00168 Rome, Italy.
EM nicolamagnavita@gmail.com
RI Magnavita, Nicola/J-6074-2014; Di Prinzio, Reparata Rosa/GRO-3110-2022
OI Meraglia, Igor/0009-0003-2847-7716; Arnesano,
   Gabriele/0000-0001-8763-2761; Di Prinzio, Reparata
   Rosa/0000-0001-5956-1038
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NR 115
TC 5
Z9 5
U1 1
U2 8
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2254-9625
J9 EUR J INVEST HEALTH
JI Eur. J. Invest. Health Psychol. Educ.
PD DEC
PY 2022
VL 12
IS 12
BP 1852
EP 1866
DI 10.3390/ejihpe12120130
PG 15
WC Psychology, Clinical
WE Emerging Sources Citation Index (ESCI)
SC Psychology
GA 7E6PU
UT WOS:000901288100001
PM 36547031
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Deschênes, SS
   Burns, RJ
   Schmitz, N
AF Deschenes, Sonya S.
   Burns, Rachel J.
   Schmitz, Norbert
TI Associations between diabetes, major depressive disorder and generalized
   anxiety disorder comorbidity, and disability: Findings from the 2012
   Canadian Community Health Survey - Mental Health (CCHS-MH)
SO JOURNAL OF PSYCHOSOMATIC RESEARCH
LA English
DT Article
DE 2012 Canadian Community Health Survey; Comorbidity; Diabetes;
   Disability; Generalized anxiety disorder; Major depressive disorder
ID CO-MORBID DEPRESSION; METABOLIC SYNDROME; RISK-FACTOR; PREVALENCE;
   MELLITUS; BURDEN; ONSET; EPIDEMIOLOGY; ADULTS; TYPE-1
AB Objective: To examine the associations between diabetes, disability, and the likelihood of comorbid major depressive disorder (MDD) and generalized anxiety disorder (GAD).
   Methods: Data were obtained from the 2012 Canadian Community Health Survey Mental Health (N = 17623). Diabetes assessment consisted of a self-reported diagnosis of diabetes made by a health care professional. Disability was assessed via self-report. 12-Month and lifetime MDD and GAD were assessed with the Composite International Diagnostic Interview 3.0.
   Results: In multinomial logistic regression models adjusted for sociodemographic and health-related factors, having diabetes was associated with a greater likelihood of 12-month comorbid MDD and GAD (OR = 1.99, 95% CI [1.22, 3.25], p = .006), compared with those with neither MDD nor GAD. No significant associations were found for MDD without GAD or GAD without MDD. This pattern of effects held when lifetime diagnoses of MDD and GAD were considered. For individuals with diabetes (n = 1730), adjusted binary logistic regression models demonstrated that with 12-month diagnoses, MDD without GAD (OR = 2.79,95% CI [139-5.621, p = .004), GAD without MDD (OR = 3.69,95% CI [1.34-10.11], p =.01), and comorbid MDD and GAD (OR = 4.17, 95% CI [1.66-10.51], p = .002) were associated with greater disability than the control group. Only comorbid MDD and GAD were associated with disability when lifetime diagnoses of MDD and GAD were considered.
   Conclusions: Individuals with diabetes may be particularly vulnerable to comorbid MDD and GAD, and MDD-GAD comorbidity may exacerbate disability in persons with diabetes. (C) 2014 Elsevier Inc. All rights reserved.
C1 [Deschenes, Sonya S.; Burns, Rachel J.; Schmitz, Norbert] McGill Univ, Fac Med, Dept Psychiat, Montreal, PQ H3A 2T5, Canada.
   [Deschenes, Sonya S.; Burns, Rachel J.; Schmitz, Norbert] Douglas Mental Hlth Univ Inst, Montreal, PQ H4H 1R3, Canada.
   [Schmitz, Norbert] McGill Univ, Fac Med, Dept Epidemiol & Biostat, Montreal, PQ, Canada.
C3 McGill University; McGill University
RP Deschênes, SS (corresponding author), Douglas Mental Hlth Univ Inst, 6875 Boul Lasalle,Frank B Common Pavil,F2117-2, Montreal, PQ H4H 1R3, Canada.
RI Deschenes, Sonya/G-6341-2017; Schmitz, Norbert/AAH-3624-2020; Schmitz,
   Norbert/A-5177-2010
OI Schmitz, Norbert/0000-0001-7777-6323; Burns, Rachel/0000-0002-5337-7878
FU Canadian Institutes for Health Research (CIHR) [MOP-106514]
FX This analysis is based on Statistics Canada's 2012 Canadian Community
   Health Survey - Mental Health (CCHS-MH), Public Use Microdata file,
   which contains anonymized data collected. All computations on these
   microdata were prepared by Sonya S. Deschenes, Rachel J. Burns, and
   Norbert Schmitz and the responsibility for the use and interpretation of
   these data is entirely that of the authors. All authors had full access
   to all of the data in the study and take responsibility for the
   integrity of the data and the accuracy of the data analysis.
   Acknowledgements/sources of funding: This research was in part funded by
   the Canadian Institutes for Health Research (CIHR Grant MOP-106514).
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NR 45
TC 42
Z9 51
U1 2
U2 28
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-3999
EI 1879-1360
J9 J PSYCHOSOM RES
JI J. Psychosomat. Res.
PD FEB
PY 2015
VL 78
IS 2
BP 137
EP 142
DI 10.1016/j.jpsychores.2014.11.023
PG 6
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA CA0US
UT WOS:000348632400006
PM 25510185
DA 2025-06-11
ER

PT J
AU Roche, KM
   Ehrlich, KB
   Vaquera, E
   Little, TD
AF Roche, Kathleen M.
   Ehrlich, Katherine B.
   Vaquera, Elizabeth
   Little, Todd D.
TI Mental Health During Early Adolescence and Later Cardiometabolic Risk: A
   Prospective Study of US Latinx Youth
SO JOURNAL OF ADOLESCENT HEALTH
LA English
DT Article
DE Cardiometabolic risk; Latinx adolescents; Mental health; Structural
   equation modeling
ID DEPRESSIVE SYMPTOMS; PHYSICAL-ACTIVITY; CHILDREN; BEHAVIOR; RELIABILITY;
   PREVALENCE; VALIDITY; INDEX; ONSET; BIRTH
AB Purpose: Rising rates of cardiometabolic risk and mental health problems are serious public health concerns for US adolescents, particularly those of Latinx origin. This research examines how Latinx youth's internalizing symptoms during early adolescence are related to sleep problems, over-weight/obesity, sedentary behavior, physical activity, healthy diet, and hypertension or diabetes risk during middle and late adolescence. Methods: Participants included 547 adolescents listed as "Hispanic" on 2017-18 middle school enrollment lists in a suburban Atlanta, GA school district. Survey data collected at baseline (2018) and four years later (2022) were analyzed using Structural Equation Model. Path estimates from baseline internalizing symptoms to later health behaviors and physical health outcomes adjusted for demographics, the follow-up measure of internalizing symptoms, and correlations among outcome variables. Missing data were handled using Full Information Maximum Likelihood. Results: At baseline, the 244 (4 4.6%) male and 303 (55.4%) female participants had a mean (standard deviation) age in years of 13.31 (0.97). Early adolescent internalizing symptoms were associated positively with later sleep problems (ss = 0.36 [95% confidence interval (CI), 0.24-0.48]), overweight/obesity (adjusted odds ratio, 2.57; 95% CI, 1.29-5.15), sedentary behavior (ss = 0.19 [95% CI, 0.09-0.30]), and internalizing symptoms (ss = 0.48 [95% CI, 0.39-0.56]) and inversely with later physical activity (ss =-0.16 [95% CI,-0.27 to -0.05]) and a healthy diet (ss =-0.21 [95% CI,-0.32 to -0.09]). Discussion: Latinx youth's internalizing symptoms during early adolescence not only track into later adolescence, but they also relate to health behaviors and outcomes underlying car-diometabolic risk during middle and late adolescence. (c) 2023 Society for Adolescent Health and Medicine. All rights reserved.
C1 [Roche, Kathleen M.] George Washington Univ, Sch Publ Hlth, Milken Inst, Dept Prevent & Community Hlth, 950 New Hampshire Ave,Suite 300, Washington, DC 20052 USA.
   [Ehrlich, Katherine B.] Univ Georgia, Dept Psychol, Athens, GA 30602 USA.
   [Vaquera, Elizabeth] George Washington Univ, Dept Sociol, Washington, DC 20052 USA.
   [Vaquera, Elizabeth] George Washington Univ, Trachtenberg Sch Publ Policy & Publ Adm, Washington, DC USA.
   [Little, Todd D.] Texas Tech Univ, Dept Educ Psychol & Leadership, Lubbock, TX 79409 USA.
   [Little, Todd D.] East China Normal Univ, Sch Psychol & Cognit Sci, Shanghai, Peoples R China.
   [Little, Todd D.] North West Univ, Optentia Res Focus Area, Vanderbijlpark, South Africa.
C3 George Washington University; University System of Georgia; University
   of Georgia; George Washington University; George Washington University;
   Texas Tech University System; Texas Tech University; East China Normal
   University; North West University - South Africa
RP Roche, KM (corresponding author), George Washington Univ, Sch Publ Hlth, Milken Inst, Dept Prevent & Community Hlth, 950 New Hampshire Ave,Suite 300, Washington, DC 20052 USA.
EM kroche@gwu.edu
RI Vaquera, Elizabeth/F-8206-2012; Ehrlich, Katherine/AAF-4687-2020
OI Roche, Kathleen/0000-0002-8456-0720
FU Eunice Kennedy Shriver National Institute of Child Health and Human
   Development, National Institutes of Health [R01 HD090232, R01 HD106650]
FX This work was funded by research grants R01 HD090232 and R01 HD106650
   from the Eunice Kennedy Shriver National Institute of Child Health and
   Human Development, National Institutes of Health.
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NR 46
TC 2
Z9 2
U1 1
U2 6
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1054-139X
EI 1879-1972
J9 J ADOLESCENT HEALTH
JI J. Adolesc. Health
PD JAN
PY 2024
VL 74
IS 1
BP 71
EP 77
DI 10.1016/j.jadohealth.2023.08.026
EA DEC 2023
PG 7
WC Psychology, Developmental; Public, Environmental & Occupational Health;
   Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Public, Environmental & Occupational Health; Pediatrics
GA EI4V4
UT WOS:001138291100001
PM 37815772
DA 2025-06-11
ER

PT J
AU Asbury, EA
   Webb, CM
   Collins, P
AF Asbury, E. A.
   Webb, C. M.
   Collins, P.
TI Group support to improve psychosocial well-being and primary-care
   demands among women with cardiac syndrome X
SO CLIMACTERIC
LA English
DT Article
DE GROUP SUPPORT; WOMEN; CHEST PAIN; PSYCHOLOGY; QUALITY OF LIFE
ID CORONARY-ARTERY-DISEASE; CHEST-PAIN; MYOCARDIAL-PERFUSION;
   HEART-DISEASE; ANGINA; ARTERIOGRAMS; DEPRESSION; ANXIETY; RISK
AB Background Women with angina pectoris, a positive exercise electrocardiogram (ECG) for myocardial ischemia and angiographically smooth coronary arteries (cardiac syndrome X), are often characterized by unresolved symptomatology and a poor quality of life. Psychological morbidity and quality of life appear to be related to social support and social isolation. An investigation of group support as an aid to treatment for cardiac syndrome X was therefore undertaken.
   Methods Forty-nine women with cardiac syndrome X (mean +/- standard deviation 61.8 +/- 8 years) were randomized to 12 monthly support group meetings or usual care control. The Health Anxiety Questionnaire (HAQ), Hospital Anxiety and Depression Scale (HADS), SF-36, York Angina Beliefs scale, ENRICHD Social Support Instrument (ESSI) and a demographic information scale, along with hospital admissions, general practitioner (GP) or cardiologist appointments were measured at baseline, 6 months and 12 months.
   Results Support group participants maintained higher levels of social support than controls (ESSI score, 17.18 +/- 5.35 vs. 14.45 +/- 6.98, p = 0.008). Near significant improvements in health beliefs total score (p - 0.068) and threat perception (p - 0.062) were found among the support group compared to the control; 29% of support patients had made one or more GP visits over the duration of the study, compared with 54% of the control group (p = 0.06).
   Conclusion Support group participation maintains social support and may reduce health-care demands and misconceived health beliefs among patients with cardiac syndrome X.
C1 [Asbury, E. A.] Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, London SW3 6LY, England.
   Royal Brompton & Harefield NHS Fdn Trust, Dept Cardiol, London, England.
C3 Imperial College London; Royal Brompton & Harefield NHS Foundation Trust
RP Asbury, EA (corresponding author), Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, Dovehouse St, London SW3 6LY, England.
OI Webb, Carolyn/0000-0002-2538-6953
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NR 36
TC 11
Z9 11
U1 0
U2 7
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1369-7137
EI 1473-0804
J9 CLIMACTERIC
JI Climacteric
PD FEB
PY 2011
VL 14
IS 1
BP 100
EP 104
DI 10.3109/13697137.2010.499181
PG 5
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA 719YS
UT WOS:000287248000016
PM 20642328
DA 2025-06-11
ER

PT J
AU López-González, AA
   Rifá, EMA
   Oliveira, HP
   Sánchez, CM
   López, PJT
   Ramírez-Manent, JI
AF Lopez-Gonzalez, a. A.
   Martinez-Almoyna Rifa, E.
   Oliveira, H. Paublini
   Sanchez, C. Martorell
   Lopez, P. J. Tarraga
   Ramirez-Manent, J. I.
TI Association between sociodemographic variables, healthy habits and
   stress with metabolic syndrome. A descriptive, cross-sectional study
SO MEDICINA DE FAMILIA-SEMERGEN
LA English
DT Article
DE Metabolic syndrome; Sociodemographic variables; Blue collar;
   Mediterranean diet; Alcohol consumption; Smoking; Stress
ID CARDIOVASCULAR-DISEASE; MENOPAUSE; OBESITY
AB Introduction: Metabolic syndrome (MS) is a pathological condition that encompasses various cardiometabolic risk factors, such as obesity, dyslipidemia, hyperglycemia, and elevated blood pressure levels. It is considered a multifactorial pathological condition. The aim of this study is to assess how variables such as age, sex, socioeconomic status, tobacco and alcohol consump- tion, physical activity, adherence to the Mediterranean diet, and stress are associated with the prevalence of MS, determined using two different criteria. Materials and Methods: This is a descriptive, cross-sectional study conducted on 24,224 Spanish workers, evaluating the association between sociodemographic variables, health habits, and stress with MS, determined using two criteria: the National Cholesterol Education Program, Adult Treatment Panel III (NCEP ATP-III), and the International Diabetes Federation (IDF). Results: All the variables analyzed showed an association with the presence of MS when applying both criteria. Among them, the variables with the strongest association were age: odds ratio 5.55 (95% CI: 4.80-6.30) for MS using the NCEP ATP-III criteria and 6.71 (95% CI: 5.30-8.13) for IDF criteria; and type of job: odds ratio 3.42 (95% CI: 2.95-3.90) for NCEP ATP-III and 3.57 (95% CI: 3.12-4.03) for IDF. Conclusions: The profile of an individual at higher risk of developing MS under both criteria would be an older male, manual laborer, smoker, habitual alcohol consumer, sedentary, with low adherence to the Mediterranean diet, and experiencing high levels of stress. (c) 2025 Sociedad Espanola de Me<acute accent>dicos de Atencio<acute accent>n Primaria (SEMERGEN). Published by Elsevier Espana, S.L.U. All rights are reserved, including those for text and data mining, AI training, and similar technologies.
C1 [Lopez-Gonzalez, a. A.; Martinez-Almoyna Rifa, E.; Oliveira, H. Paublini; Sanchez, C. Martorell; Ramirez-Manent, J. I.] Grp ADEMA Salud Inst Univ Ciencias Salud IUNICS Ba, Palma De Mallorca, Illes Balears, Spain.
   [Lopez-Gonzalez, a. A.; Martinez-Almoyna Rifa, E.; Oliveira, H. Paublini; Sanchez, C. Martorell] Escuela Univ ADEMA UIB, Fac Odontol, Palma De Mallorca, Illes Balears, Spain.
   [Lopez-Gonzalez, a. A.; Ramirez-Manent, J. I.] Serv Salud Islas Baleares, Islas Baleares, Spain.
   [Lopez, P. J. Tarraga] Univ Castilla La Mancha, Fac Med, Albacete, Spain.
   [Ramirez-Manent, J. I.] Univ Islas Baleares, Fac Med, Palma De Mallorca, Illes Balears, Spain.
C3 Universidad de Castilla-La Mancha; Universitat de les Illes Balears
RP López-González, AA (corresponding author), Grp ADEMA Salud Inst Univ Ciencias Salud IUNICS Ba, Palma De Mallorca, Illes Balears, Spain.; López-González, AA (corresponding author), Escuela Univ ADEMA UIB, Fac Odontol, Palma De Mallorca, Illes Balears, Spain.; López-González, AA (corresponding author), Serv Salud Islas Baleares, Islas Baleares, Spain.
EM pjtarraga@sescam.jccm.es
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NR 51
TC 0
Z9 0
U1 1
U2 1
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1138-3593
EI 1578-8865
J9 MED FAM-SEMERGEN
JI Med. Fam.-SEMERGEN
PD SEP
PY 2025
VL 51
IS 6
AR 102455
DI 10.1016/j.semerg.2025.102455
EA FEB 2025
PG 10
WC Primary Health Care
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA X5I3K
UT WOS:001425679600001
PM 39922044
DA 2025-06-11
ER

PT J
AU Bansal, CJ
   Bansal, AS
AF Bansal, Ciara Jade
   Bansal, Amolak Singh
TI Stress, pseudoallergens, autoimmunity, infection and inflammation in
   chronic spontaneous urticaria
SO ALLERGY ASTHMA AND CLINICAL IMMUNOLOGY
LA English
DT Review
DE Chronic urticaria; Pseudoallergens; Stress; Infections; Autoimmunity;
   Cofactors; Vitamin D3
ID CHRONIC IDIOPATHIC URTICARIA; REGULATORY T-CELL; PSYCHOLOGICAL STRESS;
   HELICOBACTER-PYLORI; MAST-CELLS; LABORATORY CHARACTERISTICS; ETIOLOGIC
   FACTORS; HOST-DEFENSE; B-CELLS; ASSOCIATION
AB Chronic spontaneous urticaria (CSU) is often associated with organ specific autoimmunity but is rarely caused by food allergy. Colourings and preservatives in pre-packaged foods, so called pseudoallergens, have also been implicated. Factors that promote inflammation or reduce anti-inflammatory mechanisms may however, predispose susceptible individuals to CSU. Chronic underlying infection and mental and emotional stress can sometimes precede the onset of CSU and once established can exacerbate the symptoms. There is early evidence of dysbiosis within the gastrointestinal tract in people with CSU and reduced levels of vitamin D are also evident. The latter may be related to the importance of vitamin D3 in increasing T regulatory function which can control a tendency to autoimmunity. It is quite possible that a state of on-going chronic inflammation with reduced anti-oxidant mechanisms may underlie the not infrequent association between CSU and metabolic syndrome. Effective treatment of CSU should involve the use of anti-histamines, intermittent steroids and anti-IgE therapy. For recalcitrant disease immune modulatory therapy has a place. However, talking therapies that reduce stress and anxiety, vitamin D3 supplementation, correction of intestinal dysbiosis and treatment of any chronic infection should also be considered.
C1 [Bansal, Ciara Jade] St Barts Queen Marys Univ, London, England.
   [Bansal, Amolak Singh] St Helier Hosp, Carshalton SM5 1AA, Surrey, England.
C3 St Helier Hospital
RP Bansal, AS (corresponding author), St Helier Hosp, Carshalton SM5 1AA, Surrey, England.
EM Amolak.Bansal@nhs.net
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NR 121
TC 56
Z9 59
U1 0
U2 15
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1710-1492
J9 ALLERGY ASTHMA CL IM
JI Allerg Asthma Clin. Immunol.
PD SEP 11
PY 2019
VL 15
IS 1
AR 56
DI 10.1186/s13223-019-0372-z
PG 11
WC Allergy; Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Allergy; Immunology
GA IX7NS
UT WOS:000485871700001
PM 31528163
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Garcia-Rios, A
   Delgado-Lista, J
   Perez-Martinez, P
   Delgado-Casado, N
   Perez-Jimenez, F
   Lopez-Miranda, J
AF Garcia-Rios, Antonio
   Delgado-Lista, Javier
   Perez-Martinez, Pablo
   Delgado-Casado, Nieves
   Perez-Jimenez, Francisco
   Lopez-Miranda, Jose
TI Relevance of Postprandial Lipemia in Metabolic Syndrome
SO CURRENT VASCULAR PHARMACOLOGY
LA English
DT Article
DE Endothelial dysfunction; inflammation; metabolic syndrome;
   nutrigenetics; oxidative stress; postprandial lipemia
ID POLYUNSATURATED FATTY-ACIDS; LIPASE GENE VARIATION; VIRGIN OLIVE OIL;
   ENDOTHELIAL FUNCTION; OXIDATIVE STRESS; NONFASTING TRIGLYCERIDES;
   MELANOCORTIN-4 RECEPTOR; LIPOPROTEIN METABOLISM; MYOCARDIAL-INFARCTION;
   EXERCISE INTERVENTION
AB Metabolic Syndrome (MetS) is a complex disorder defined by the aggregation of interconnected cardiometabolic risk factors which increase the risk of diabetes mellitus type 2 and cardiovascular disease (CVD). MetS is currently a matter of concern and it will continue to be in the future, since there is likely to be a dramatic increase in its prevalence, and subjects with MetS will have an increased risk of mortality, mainly through CVD. Moreover, the implications on the global health burden and the worldwide epidemic of this complex disorder will impact greatly on socioeconomic cost. MetS is therefore a matter of serious concern and we need to understand its etiology in order to improve strategies of treatment and prevention. In this regard, postprandial lipemia has increased in importance over the last few years as it has been demonstrated to influence the development of atherosclerosis. In addition, in modern times, fasting is not the typical physiological state of humans; in fact, they spend most of the time in the postprandial state. However, although it is obvious that postprandial lipemia is present in conditions of obesity, little is known about the relevance of postprandial lipemia in MetS. In the current review, we will explore some aspects of postprandial lipemia which could be of interest for understanding the pathogenesis of this complex disorder and which may help us advance towards more personalized nutrition.
C1 Univ Cordoba, Reina Sofia Univ Hospital, IMIBIC, Lipid & Atherosclerosis Unit, E-14071 Cordoba, Spain.
   Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr CIBEROBN, Madrid, Spain.
C3 Universidad de Cordoba; CIBER - Centro de Investigacion Biomedica en
   Red; CIBEROBN; Instituto de Salud Carlos III
RP Lopez-Miranda, J (corresponding author), Hosp Univ Reina Sofia, Serv Med Interna, Unidad Lipidos & Arteriosclerosis, Edificio Consultas Externas,2a Planta, Cordoba 14004, Spain.
EM jlopezmir@uco.es
RI Delgado-Lista, Javier/KAM-7412-2024; Jimenez, Francisco/AAJ-9559-2021;
   Lopez-Miranda, Jose/Y-8306-2019; Tejada, Silvia/L-7297-2014; Perez
   Martinez, Pablo/AEL-6176-2022
OI Lopez-Miranda, Jose/0000-0002-8844-0718; Delgado Lista, Francisco
   Javier/0000-0002-2982-2716; Perez-Jimenez,
   Francisco/0000-0001-7499-7681; Perez Martinez,
   Pablo/0000-0001-7716-8117; Perez Jimenez, Francisco/0000-0001-9808-1280
FU Spanish Ministry of Science and Innovation [AGL 2004-07907,
   AGL2006-01979, AGL2009-12270, SAF07-62005, FIS PI10/01041, PI10/02412];
   Consejeria de Economia, Innovacion y Ciencia, Proyectos de Investigacion
   de Excelencia, Junta de Andalucia [P06-CTS-01425, CTS5015, AGR922];
   Consejeria de Salud, Junta de Andalucia [06/128, 07/43, PI0193/09,
   06/129, 0118/08, PI-0252/09, PI-0058/10]; Fondo Europeo de Desarrollo
   Regional (FEDER); Centro de Excelencia Investigadora en Aceite de Oliva
   y Salud (CEAS); ISCIII (Programa Rio-Hortega)
FX Source of Support: Supported in part by public funds: research grants
   from the Spanish Ministry of Science and Innovation (AGL 2004-07907,
   AGL2006-01979, and AGL2009-12270 to J L-M, SAF07-62005 to F P-J and FIS
   PI10/01041 to P P-M, PI10/02412 to F P-J); Consejeria de Economia,
   Innovacion y Ciencia, Proyectos de Investigacion de Excelencia, Junta de
   Andalucia (P06-CTS-01425 to J LM, CTS5015 and AGR922 to F P-J);
   Consejeria de Salud, Junta de Andalucia (06/128, 07/43, and PI0193/09 to
   J L-M, 06/129 to F P-J, 0118/08 to F F-J, PI-0252/09 to J D-L, and
   PI-0058/10 to P P-M); Fondo Europeo de Desarrollo Regional (FEDER);
   Centro de Excelencia Investigadora en Aceite de Oliva y Salud (CEAS).
   The CIBEROBN is an initiative of the Instituto de Salud Carlos III,
   Madrid, Spain. AG-R is supported by a research contract with ISCIII
   (Programa Rio-Hortega).
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NR 84
TC 7
Z9 7
U1 0
U2 6
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1570-1611
EI 1875-6212
J9 CURR VASC PHARMACOL
JI Current Vascular Pharmacology
PD NOV
PY 2013
VL 11
IS 6
BP 920
EP 927
DI 10.2174/15701611113116660172
PG 8
WC Pharmacology & Pharmacy; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Cardiovascular System & Cardiology
GA AA4IC
UT WOS:000331058300011
PM 24168444
DA 2025-06-11
ER

PT J
AU Mitsiou, E
   Kyriakou, A
   Parlapani, E
   Trigoni, A
   Trakatelli, M
   Apalla, Z
   Sotiriadis, D
   Lazaridou, E
   Patsatsi, A
AF Mitsiou, Eleni
   Kyriakou, Aikaterini
   Parlapani, Eleni
   Trigoni, Anastasia
   Trakatelli, Myrto
   Apalla, Zoe
   Sotiriadis, Dimitrios
   Lazaridou, Elizabeth
   Patsatsi, Aikaterini
TI Correlation of Specific Inflammatory Markers With the Occurrence of
   Depression in Patients With Psoriasis and Their Use as Biomarkers for
   the Diagnosis of Depression
SO DERMATOLOGY PRACTICAL & CONCEPTUAL
LA English
DT Article
DE psoriasis; depression; inflammation; CRP; ESR
ID QUALITY-OF-LIFE; NECROSIS-FACTOR-ALPHA; C-REACTIVE PROTEIN; SEVERITY
   INDEX; SYMPTOMS; CYTOKINES; MODERATE; ANXIETY; INTERVENTIONS;
   SATISFACTION
AB Introduction: Psoriasis is a systemic disease of the skin and nails associated with a wide range of comorbidities such as depression, psoriatic arthritis and metabolic syndrome. Objectives: The study aimed to examine a potential association between inflammatory markers (C- reactive protein [CRP] and erythrocyte sedimentation rate [ESR]) and depression in patients with psoriasis. Methods: A total of 80 individuals were enrolled in the study. Case participants included 28 patients diagnosed with Psoriasis (Beck Depression Inventory -II: :0-13) and 24 patients diagnosed with Psoriasis and Depression (Beck Depression Inventory-II:14-63). Twenty-eight (28) healthy participants comprised the control group. Psoriasis severity was evaluated by using Psoriasis Area and Severity Index, Physician Global Assessment, Body Surface Area and Dermatology Life Quality Index. Written approval was obtained for its use in this study: Cardiff University (09/2015). Other factors considered in the study were obesity using the Body Mass Index, the levels of stress using the Beck Anxiety Inventory, and the presence of insomnia using the Athens Insomnia Scale. Blood draws and inflammatory markers measurements were performed for all participants. Results: Both CRP and ESR levels were higher in the case group (ie Psoriasis and Depression and Psoriasis) compared to healthy controls. Furthermore, psoriatic patients with depression showed increased CRP and ESR levels compared to those of psoriatic patients without depression. Conclusions: The evaluation of both CRP and ESR and their use to detect the presence of depression in patients with psoriasis can be an important tool for their holistic treatment of theirs.
C1 [Mitsiou, Eleni; Kyriakou, Aikaterini; Trigoni, Anastasia; Trakatelli, Myrto; Apalla, Zoe; Sotiriadis, Dimitrios; Lazaridou, Elizabeth; Patsatsi, Aikaterini] Aristotle Univ Thessaloniki, Sch Med, Papageorgiou Hosp, Dermatol Dept 2, Thessaloniki, Greece.
   [Parlapani, Eleni] Aristotle Univ Thessaloniki, Fac Med, Dept Psychiat 1, Thessaloniki, Greece.
   [Mitsiou, Eleni] Aristotle Univ Thessaloniki, Sch Med, Dermatol Dept 2, Elias 6, Veroia GR-59132, Greece.
C3 Papageorgiou Hospital; Aristotle University of Thessaloniki; Aristotle
   University of Thessaloniki; Aristotle University of Thessaloniki
RP Mitsiou, E (corresponding author), Aristotle Univ Thessaloniki, Sch Med, Dermatol Dept 2, Elias 6, Veroia GR-59132, Greece.
EM mitsiou_elena@yahoo.gr
RI Parlapani, Eleni/ABB-7433-2020; Patsatsi, Aikaterini/ABB-5223-2020
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NR 64
TC 3
Z9 3
U1 1
U2 3
PU MATTIOLI 1885
PI FIDENZA
PA VIA DELLA LODESANA 649-SX, FIDENZA, 43046 PR, ITALY
SN 2160-9381
J9 DERMATOL PRACT CONCE
JI Dermatol. Pract. Concept.
PD APR
PY 2024
VL 14
IS 2
AR e2024104
DI 10.5826/dpc.1402a104
PG 10
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA RU7M4
UT WOS:001230239800014
PM 38810053
OA gold, Green Accepted
DA 2025-06-11
ER

PT J
AU Barazzoni, R
   Silva, V
   Singer, P
AF Barazzoni, Rocco
   Silva, Veronica
   Singer, Pierre
TI Clinical Biomarkers in Metabolic Syndrome
SO NUTRITION IN CLINICAL PRACTICE
LA English
DT Review
DE nutrition therapy; metabolic syndrome X; biological markers; biomarkers;
   insulin resistance
ID HOMEOSTASIS MODEL ASSESSMENT; INDUCED INSULIN-RESISTANCE; GLUCOSE CLAMP
   TECHNIQUE; TIME PHYSICAL-ACTIVITY; TUMOR-NECROSIS-FACTOR; HUMAN
   ADIPOSE-TISSUE; KAPPA-B ACTIVATION; SKELETAL-MUSCLE; OXIDATIVE STRESS;
   URIC-ACID
AB A biomarker can be defined as a measurable variable that may be used as an indicator of a given biological state or condition. Biomarkers have been used in health and disease for diagnostic purposes, as tools to assess effectiveness of nutritional or drug intervention, or as risk markers to predict the development of certain diseases. In nutrition studies, selecting appropriate biomarkers is important to assess compliance, or incidence of a particular dietary component in the biochemistry of the organism, and in the diagnosis and prognosis of nutrition-related diseases. Metabolic syndrome is a cluster of cardiovascular risk factors that occur simultaneously in the same individual, and it is associated with systemic alterations that may involve several organs and tissues. Given its close association with obesity and the increasing prevalence of obesity worldwide, identifying obese individuals at risk for metabolic syndrome is a major clinical priority. Biomarkers for metabolic syndrome are therefore potential important tools to maximize the effectiveness of treatment in subjects who would likely benefit the most. Choice of biomarkers may be challenging due to the complexity of the syndrome, and this article will mainly focus on nutrition biomarkers related to the diagnosis and prognosis of the metabolic syndrome.
C1 [Barazzoni, Rocco] Univ Trieste, Dept Med Surg & Hlth Sci, Trieste, Italy.
   [Silva, Veronica; Singer, Pierre] Beilinson Med Ctr, Rabin Med Ctr, Inst Nutr Res, Petah Tiqwa, Israel.
   [Singer, Pierre] Beilinson Med Ctr, Rabin Med Ctr, Dept Gen Intens Care, Petah Tiqwa, Israel.
   [Singer, Pierre] Tel Aviv Univ, Sackler Sch Med, IL-69978 Tel Aviv, Israel.
C3 University of Trieste; Tel Aviv University; Rabin Medical Center; Rabin
   Medical Center; Tel Aviv University; Tel Aviv University; Sackler
   Faculty of Medicine
RP Singer, P (corresponding author), Beilinson Med Ctr, Rabin Med Ctr, Inst Nutr Res, Jabotinsky 39, Petah Tiqwa, Israel.
EM psinger@clalit.org.il
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NR 106
TC 13
Z9 15
U1 1
U2 31
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0884-5336
EI 1941-2452
J9 NUTR CLIN PRACT
JI Nutr. Clin. Pract.
PD APR
PY 2014
VL 29
IS 2
BP 215
EP 221
DI 10.1177/0884533613516168
PG 7
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA AC8FJ
UT WOS:000332768600007
PM 24336524
DA 2025-06-11
ER

PT J
AU Vázquez, CMP
   Costa, JO
   Bomfim, LGS
   Pires, LV
   da Silva, DG
   Fukutani, KF
   de Jesus, AR
   Silva, ND
   Santana, GD
   de Moura, TR
   Barbosa, K
AF Passos Vazquez, Cecilia Maria
   Costa, Jamille Oliveira
   Santos Bomfim, Lays Gisele
   Pires, Liliane Viana
   da Silva, Danielle Goes
   Fukutani, Kiyoshi Ferreira
   de Jesus, Amelia Ribeiro
   Silva, Natanael de Jesus
   Santana, Gleiciane de Jesus
   de Moura, Tatiana Rodrigues
   Barbosa, Kiriaque
TI Oxidized Low-Density Lipoprotein (Ox-LDL) and Triggering
   Receptor-Expressed Myeloid Cell (TREM-1) Levels Are Associated with
   Cardiometabolic Risk in Nonobese, Clinically Healthy, and Young Adults
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Article
ID SWEETENED BEVERAGE INTAKE; BODY-MASS INDEX; METABOLIC SYNDROME;
   OXIDATIVE STRESS; WAIST CIRCUMFERENCE; ABDOMINAL OBESITY;
   BLOOD-PRESSURE; POPULATION; PREVALENCE; INFLAMMATION
AB Oxidative and inflammatory substances play an important role in the genesis of processes related to cardiometabolic risk. High levels of oxidized low-density lipoprotein (Ox-LDL) and of triggering receptor-expressed myeloid cells (TREM-1) are associated with cardiovascular and inflammatory diseases. In this study, we evaluate the association of the plasma concentrations of Ox-LDL and serum levels of circulating TREM-1 (sTREM-1) with the components of cardiometabolic risk (CMR) and other associated risk parameters. Although the individuals in this study were young, nonobese, and did not have signs, symptoms, and diagnosis of diseases, they already presented components of CMR. Ox-LDL lipid fraction correlated positively with CMR-related markers: body mass index (BMI), waist circumference (WC), body fat percentage, total cholesterol, LDL-c, VLDL-c, triglycerides, atherogenic cholesterol, and atherogenic index. Among these parameters, atherogenic cholesterol had a greater predictive effect for Ox-LDL alterations. Individuals with higher serum concentrations of sTREM-1 presented higher values for BMI, WC, triglycerides, VLDL-c, and atherogenic cholesterol. WC showed an effect on the association between the sTREM-1's inflammatory response and the components of CMR. The association of oxidative and inflammatory markers with anthropometric parameters and atherogenic cholesterol in nonobese, clinically healthy, and young individuals suggests the importance of early evaluation of these markers in order to prevent future cardiac events.
C1 [Passos Vazquez, Cecilia Maria; Costa, Jamille Oliveira; Santos Bomfim, Lays Gisele; Pires, Liliane Viana; da Silva, Danielle Goes; de Jesus, Amelia Ribeiro; Santana, Gleiciane de Jesus; de Moura, Tatiana Rodrigues; Barbosa, Kiriaque] Fed Univ Sergipe UPS, Aracaju, SE, Brazil.
   [Fukutani, Kiyoshi Ferreira] Sao Paulo Univ USP, Ribeirao Preto, SP, Brazil.
   [Silva, Natanael de Jesus] Fed Univ Bahia UFBA, Salvador, BA, Brazil.
C3 Universidade Federal da Bahia
RP Barbosa, K (corresponding author), Fed Univ Sergipe UPS, Aracaju, SE, Brazil.
EM kiribarra@yahoo.com.br
RI de Jesus Silva, Natanael/AAS-2223-2021; de Moura, Tatiana/L-4556-2016;
   Fukutani, Kiyoshi/T-1630-2019; Barbosa, Kiriaque/E-4269-2014
OI de Jesus Silva, Natanael/0000-0003-3002-1032; PIRES,
   LILIANE/0000-0003-1710-0836
FU Fundacao de Apoio a Pesquisa e a Inovacao Tecnologica do Estado de
   Sergipe
FX This study was funded by Fundacao de Apoio a Pesquisa e a Inovacao
   Tecnologica do Estado de Sergipe.
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NR 53
TC 7
Z9 8
U1 0
U2 0
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PY 2019
VL 2019
AR 7306867
DI 10.1155/2019/7306867
PG 8
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA HO4TW
UT WOS:000460916600001
PM 30944697
OA Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Hawkins, MAW
   Stewart, JC
AF Hawkins, Misty A. W.
   Stewart, Jesse C.
TI Do negative emotional factors have independent associations with excess
   adiposity?
SO JOURNAL OF PSYCHOSOMATIC RESEARCH
LA English
DT Review
DE Adiposity; Anger; Anxiety; Depression; Hostility; Obesity
ID CORONARY-HEART-DISEASE; BODY-MASS INDEX; NATIONAL EPIDEMIOLOGIC SURVEY;
   RISK-FACTORS; CARDIOVASCULAR-DISEASE; WEIGHT-GAIN; DEPRESSIVE SYMPTOMS;
   WAIST CIRCUMFERENCE; METABOLIC SYNDROME; PANIC DISORDER
AB Objective: Taken in isolation, depression, anxiety, and hostility/anger have been shown to predict obesity. It is unknown whether these negative emotional factors are associated with adiposity, independently of each other. The objective of this review was to determine whether negative emotional factors have independent associations with adiposity.
   Methods: We searched for observational studies examining adiposity and two or more negative emotional factors. Studies which examined a negative emotional factor using analyses which controlled for other emotional factor(s) were selected for the review.
   Results: Three prospective and 11 cross-sectional studies met our inclusion/exclusion criteria. Of these investigations, 64% indicated that depression had positive associations with adiposity, independent of anxiety or hostility, and 56% indicated that anxiety had independent associations with adiposity. Only 33% of studies found independent associations for hostility and adiposity: however, far fewer studies were available.
   Conclusion: Depression and anxiety have independent associations with excess adiposity when controlling for other emotional factors. Additional studies are needed to determine whether hostility/anger is independently associated with excess adiposity. These results have implications for the design of effective obesity prevention programs. (C) 2012 Elsevier Inc. All rights reserved.
C1 [Hawkins, Misty A. W.; Stewart, Jesse C.] Indiana Univ Purdue Univ, Dept Psychol, Indianapolis, IN 46202 USA.
C3 Purdue University System; Purdue University; Purdue University in
   Indianapolis
RP Stewart, JC (corresponding author), Indiana Univ Purdue Univ, Dept Psychol, 402 N Blackford St,LD 100E, Indianapolis, IN 46202 USA.
EM jstew@iupui.edu
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NR 79
TC 14
Z9 18
U1 0
U2 13
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-3999
EI 1879-1360
J9 J PSYCHOSOM RES
JI J. Psychosomat. Res.
PD OCT
PY 2012
VL 73
IS 4
BP 243
EP 250
DI 10.1016/j.jpsychores.2012.07.009
PG 8
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 009OK
UT WOS:000309034900001
PM 22980527
DA 2025-06-11
ER

PT J
AU Altuntas, SÇ
   Çelik, Ö
   Özer, Ü
   Çolak, S
AF Altuntas, Seher Cetinkaya
   Celik, Ozlem
   Ozer, Urun
   Colak, Sabri
TI Depression, anxiety, body image scores, and sexual dysfunction in
   patients with polycystic ovary syndrome according to phenotypes
SO GYNECOLOGICAL ENDOCRINOLOGY
LA English
DT Article
DE Phenotypes of polycystic ovary syndrome; depression; anxiety; body
   image; sexual dysfunction
ID QUALITY-OF-LIFE; CARDIOMETABOLIC RISK; ANDROGEN EXCESS; WOMEN;
   PREVALENCE; CONSENSUS; SYMPTOMS; CRITERIA; PCOS; DISORDERS
AB Background: Polycystic ovary syndrome (PCOS) has been linked to both mental and metabolic disturbances. The purpose of this research was to investigate psychological features such as anxiety and depression, body image, sexual dysfunction, and associated factors among the PCOS phenotypes and to compare these with healthy controls. Methods: The study involved 167 reproductive-age women with PCOS and 73 healthy controls. Standardized scales assessing depression (the Beck Depression Inventory [BDI]), depression and anxiety (the Hospital Anxiety and Depression Scale [HADS] and the General Health Questionnaire [GHQ]), and body image scale (the Body Cathexis Scale [BCS]) were administered to all participants. Hirsutism scores, serum androgen levels, and metabolic parameters were recorded. Results: Significantly higher BDI, HADS depression, and GHQ scores, and a more negative body image in terms of BCS scores were observed in the women with PCOS than in the healthy controls. BDI scores were significantly higher in phenotypes A, B, and D compared with the healthy controls. No significant difference was observed in BDI and HADS depression scores among the phenotypes. Significant differences were observed only between phenotype A and the control group in terms of HADS depression and GHQ scores. BCS scores were significantly higher in phenotypes A, B, and C than in the healthy controls. No significant difference was determined in Female Sexual Function Index (FSFI) scores between the PCOS phenotypes and the healthy controls. When all participants were divided into three groups based on body mass index (BMI), a statistically significant difference was observed only between the phenotype A lean group (BMI: 18.5-24.9 kg/m(2)) and the control group in terms of BDI, HADS depression, and BCS scores. Conclusions: BDI, HADS depression scores, and GHQ scores were all higher in patients with PCOS compared with the healthy controls. These features were more pronounced in phenotypes A and B, including hyperandrogenism and oligo-anovulation. Physicians should be aware of the high risk of these disorders in women with PCOS.
C1 [Altuntas, Seher Cetinkaya] Univ Hlth Sci, Bursa Yuksek Ihtisas Educ & Training Hosp, Dept Internal Med, Div Endocrinol & Metab, Bursa, Turkey.
   [Celik, Ozlem] Acibadem Univ, Sch Med, Dept Internal Med, Div Endocrinol & Metab, Istanbul, Turkey.
   [Ozer, Urun] Acibadem Univ, Sch Med, Dept Psychiat, Istanbul, Turkey.
   [Colak, Sabri] Bahceci Bursa Assisted Reprod Ctr, Bursa, Turkey.
C3 University of Health Sciences Turkey; Yuksek Ihtisas Training & Research
   Hospital; Acibadem University; Acibadem University
RP Altuntas, SÇ (corresponding author), Univ Hlth Sci, Bursa Yuksek Ihtisas Educ & Training Hosp, Dept Internal Med, Div Endocrinol & Metab, Bursa, Turkey.
EM drsehercetinkaya@hotmail.com
RI colak, sabri/AAS-4006-2020; CELIK, OZLEM/HPC-2361-2023
OI CELIK, OZLEM/0000-0001-5149-8716
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NR 49
TC 9
Z9 10
U1 3
U2 14
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0951-3590
EI 1473-0766
J9 GYNECOL ENDOCRINOL
JI Gynecol. Endocrinol.
PD OCT 3
PY 2022
VL 38
IS 10
BP 849
EP 855
DI 10.1080/09513590.2022.2118708
EA AUG 2022
PG 7
WC Endocrinology & Metabolism; Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Obstetrics & Gynecology
GA 6A3CE
UT WOS:000853167500001
PM 36093888
DA 2025-06-11
ER

PT J
AU Kagota, S
   Tada, Y
   Kubota, Y
   Nejime, N
   Yamaguchi, Y
   Nakamura, K
   Kunitomo, M
   Shinozuka, K
AF Kagota, Satomi
   Tada, Yukari
   Kubota, Yoko
   Nejime, Namie
   Yamaguchi, Yu
   Nakamura, Kazuki
   Kunitomo, Masaru
   Shinozuka, Kazumasa
TI Peroxynitrite is involved in the dysfunction of vasorelaxation in
   SHR/NDmcr-cp rats, spontaneously hypertensive obese rats
SO JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
LA English
DT Article
DE (3-6): metabolic syndrome; nitric oxide; oxidative stress;
   peroxynitrite; vasorelaxation
ID DIABETIC FAT RAT; ENDOTHELIAL DYSFUNCTION; METABOLIC SYNDROME;
   ANGIOTENSIN-II; INSULIN-RESISTANCE; NITROSATIVE STRESS; KOLETSKY RAT;
   SYNDROME-X; RECEPTOR; AMLODIPINE
AB SHR/NDmcr-cp (SHR-cp) rats display typical symptoms and features of the metabolic syndrome. We previously reported that endothelium-dependent relaxation decreases in the thoracic aortas of SHR-cp rats, despite increased nitric oxide (NO) production from the endothelium. In the present study, to search for the reasons for this contradiction, we investigated whether vascular abnormality could be reduced by treatment of SHR-cp rats with antihypertensive drugs; a calcium channel blocker (amlodipine), an alpha 2 and imidazoline receptor agonist (moxonidine), and an angiotensin II type 1 (AT1) receptor antagonist (telmisartan). Telmisartan but not amlodipine and moxonidine ameliorated the impairment of relaxation in response to acetylcholine and the increased protein expression of endothelium NO synthase in thoracic aortas. All three drugs significantly lowered the blood pressure. Telmisartan decreased the serum levels of lipid peroxide and 8-hydroxy-2'-deoxyguanosine, oxidative stress markers, and also the aortic levels of the protein expression of gp91(phox), a component of NADPH oxidase, and 3-nitrotyrosine, a biomarker of peroxynitrite. These findings suggest that NADPH oxidase-derived superoxide, probably produced due to stimulation of AT1 receptors, reacts with NO to form peroxynitrite, and consequently decreases active NO, leading to attenuation of endothelium-dependent relaxation. Angiotensin receptor antagonists may be effective for preventing endothelial dysfunction in metabolic syndrome.
C1 [Kagota, Satomi; Tada, Yukari; Kubota, Yoko; Nejime, Namie; Yamaguchi, Yu; Nakamura, Kazuki; Kunitomo, Masaru; Shinozuka, Kazumasa] Mukogawa Womens Univ, Sch Pharm & Pharmaceut Sci, Dept Pharmacol, Nishinomiya, Hyogo, Japan.
C3 Mukogawa Women's University
RP Kagota, S (corresponding author), 11-68 Koshien Kyuban Cho, Nishinomiya, Hyogo 6638179, Japan.
EM skagota@mukogawa-u.acjp
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NR 42
TC 33
Z9 35
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0160-2446
EI 1533-4023
J9 J CARDIOVASC PHARM
JI J. Cardiovasc. Pharmacol.
PD DEC
PY 2007
VL 50
IS 6
BP 677
EP 685
DI 10.1097/FJC.0b013e3181583d80
PG 9
WC Cardiac & Cardiovascular Systems; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Pharmacology & Pharmacy
GA 248NV
UT WOS:000252161300011
PM 18091585
OA Bronze
DA 2025-06-11
ER

PT J
AU Huang, XH
   Liang, J
   Zhang, JY
   Fu, JY
   Xie, WX
   Zheng, FF
AF Huang, Xinghe
   Liang, Jie
   Zhang, Junyu
   Fu, Jiayi
   Xie, Wuxiang
   Zheng, Fanfan
TI Association of cardiovascular-kidney-metabolic health and social
   connection with the risk of depression and anxiety
SO PSYCHOLOGICAL MEDICINE
LA English
DT Article
DE anxiety; cardiovascular-kidney-metabolic syndrome; depression;
   loneliness; social isolation
ID UK BIOBANK; DIABETES-MELLITUS; DISEASE; LONELINESS; PREVALENCE;
   DISORDERS; STATEMENT
AB Background. To explore the association of cardiovascular-kidney-metabolic (CKM) health with the risk of depression and anxiety and to investigate the joint association of CKM health and social connection with depression and anxiety. Methods. This prospective cohort study included 344 956 participants from the UK Biobank. CKM syndrome was identified as a medical condition with the presence of metabolic risk factors, cardiovascular disease, and chronic kidney disease, and was classified into five stages (stage 0-4) in this study. Loneliness and social isolation status were determined by self- reported questionnaires. Cox proportional hazards models were applied for analyses. Results. Compared with participants in stage 0, the HRs for depression were 1.17 (95% CI 1.10-1.25), 1.40 (95% CI 1.33-1.48), and 2.14 (95% CI 1.98-2.31) for participants in stage 1, 2-3, and 4, respectively. Similarly, participants in stage 2-3 (HR = 1.20, 95% CI 1.14-1.26) and stage 4 (HR = 1.63, 95% CI 1.51-1.75) had greater risks of incident anxiety. We found additive interactions between loneliness and CKM health on the risk of depression and anxiety. Participants simultaneously reported being lonely and in stage 4 had the greatest risk of depression (HR = 4.44, 95% CI 3.89-5.07) and anxiety (HR = 2.58, 95% CI 2.21-3.01) compared with those without loneliness and in stage 0. We also observed an additive interaction between social isolation and CKM health on the risk of depression. Conclusions. Our findings suggest the importance of comprehensive interventions to improve CKM health and social connection to reduce the disease burden of depression and anxiety.
C1 [Huang, Xinghe; Liang, Jie; Zhang, Junyu; Fu, Jiayi; Zheng, Fanfan] Chinese Acad Med Sci & Peking Union Med Coll, Sch Nursing, Beijing 100144, Peoples R China.
   [Xie, Wuxiang] Peking Univ, Peking Univ First Hosp, Clin Res Inst, Beijing 100191, Peoples R China.
   [Xie, Wuxiang] Peking Univ, Key Lab Epidemiol Major Dis, Minist Educ, Beijing 100191, Peoples R China.
C3 Chinese Academy of Medical Sciences - Peking Union Medical College;
   Peking Union Medical College; Peking University; Peking University;
   Ministry of Education - China
RP Zheng, FF (corresponding author), Chinese Acad Med Sci & Peking Union Med Coll, Sch Nursing, Beijing 100144, Peoples R China.; Xie, WX (corresponding author), Peking Univ, Peking Univ First Hosp, Clin Res Inst, Beijing 100191, Peoples R China.; Xie, WX (corresponding author), Peking Univ, Key Lab Epidemiol Major Dis, Minist Educ, Beijing 100191, Peoples R China.
EM xiewuxiang@hsc.pku.edu.cn; zhengfanfan@nursing.pumc.edu.cn
RI Fu, Jiayi/KYP-8969-2024; Xie, Wuxiang/GYU-3990-2022
OI Migunov, Andrei/0000-0002-1003-2757; Zheng, Fanfan/0000-0003-2767-2600
FU Non-profit Central Research Institute Fund of Chinese Academy of Medical
   Sciences [90492]; U.S. Department of Energy (DOE) [DE-SC0024278] Funding
   Source: U.S. Department of Energy (DOE)
FX We are grateful to UK Biobank participants. This research has been
   conducted using the UK Biobank resource under application number 90492.
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NR 52
TC 6
Z9 6
U1 18
U2 20
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0033-2917
EI 1469-8978
J9 PSYCHOL MED
JI Psychol. Med.
PD NOV
PY 2024
VL 54
IS 15
BP 4203
EP 4211
DI 10.1017/S0033291724002381
EA NOV 2024
PG 9
WC Psychology, Clinical; Psychiatry; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA W2U6U
UT WOS:001358028800001
PM 39552398
OA hybrid
DA 2025-06-11
ER

PT J
AU Peneva, VM
   Terzieva, DD
   Mitkov, MD
AF Peneva, Vania Miloucheva
   Terzieva, Dora Dimitrova
   Mitkov, Mitko Dimitrov
TI Role of Melatonin in the Onset of Metabolic Syndrome in Women
SO BIOMEDICINES
LA English
DT Review
DE metabolic syndrome; women; melatonin; leptin; ghrelin
ID INSULIN-RESISTANCE; BLOOD-PRESSURE; GLUCOSE-TOLERANCE; OXIDATIVE STRESS;
   CONTROLLED-TRIAL; LEPTIN; RISK; ASSOCIATION; PREVALENCE; SECRETION
AB Metabolic syndrome (MetS) is a constellation of several associated cardiometabolic risk factors that increase the risk of developing type 2 diabetes mellitus (T2DM), cardiovascular diseases, and mortality. The role of hormonal factors in the development of MetS is assumed. In women, an insulin-resistant state that is associated with polycystic ovarian syndrome and increased deposition of intra-abdominal adipose tissue promotes the development of MetS and increases cardiovascular risk. The neuroendocrine hormone melatonin is secreted mainly at night under the regulatory action of the suprachiasmatic nucleus in the hypothalamus. Melatonin secretion is influenced by exogenous factors such as light and seasons and endogenous factors such as age, sex, and body weight. At present, the role of melatonin in metabolic disorders in humans is not fully understood. In this review, we set out to analyze the relationship of melatonin with the main features of MetS in women. Data from experimental and clinical studies on the role of melatonin in glucose metabolism and on the involvement of melatonin in lipid disturbances in MetS are reviewed. The complex influence of melatonin on hypertension is discussed. The changes in melatonin, leptin, and ghrelin and their relation to various metabolic processes and vascular dysfunction are discussed.
C1 [Peneva, Vania Miloucheva; Terzieva, Dora Dimitrova] Med Univ, Fac Pharm, Dept Clin Lab, Plovdiv 4002, Bulgaria.
   [Mitkov, Mitko Dimitrov] Med Univ, Fac Med, Dept Endocrinol, Plovdiv 4002, Bulgaria.
C3 Medical University Plovdiv; Medical University Plovdiv
RP Peneva, VM (corresponding author), Med Univ, Fac Pharm, Dept Clin Lab, Plovdiv 4002, Bulgaria.
EM vanya.peneva@mu-plovdiv.bg; terzieva2006@yahoo.com;
   mitko.mitkov@mu-plovdiv.bg
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NR 61
TC 2
Z9 2
U1 0
U2 12
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2227-9059
J9 BIOMEDICINES
JI Biomedicines
PD JUN
PY 2023
VL 11
IS 6
AR 1580
DI 10.3390/biomedicines11061580
PG 10
WC Biochemistry & Molecular Biology; Medicine, Research & Experimental;
   Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Research & Experimental Medicine;
   Pharmacology & Pharmacy
GA K1HE1
UT WOS:001014016500001
PM 37371675
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Innes, KE
   Vincent, HK
   Taylor, AG
AF Innes, Kim E.
   Vincent, Heather K.
   Taylor, Ann Gill
TI CHRONIC STRESS AND INSULIN RESISTANCE-RELATED INDICES OF CARDIOVASCULAR
   DISEASE RISK, PART 2: A POTENTIAL ROLE FOR MIND-BODY THERAPIES
SO ALTERNATIVE THERAPIES IN HEALTH AND MEDICINE
LA English
DT Article
ID TAI-CHI-CHUAN; CORONARY-HEART-DISEASE; RANDOMIZED CONTROLLED-TRIAL;
   VAGUS NERVE-STIMULATION; BLOOD-PRESSURE; AEROBIC EXERCISE; METABOLIC
   SYNDROME; CAROTID ATHEROSCLEROSIS; ESSENTIAL-HYPERTENSION; SYMPATHETIC
   ACTIVITY
AB Cardiovascular disease (CVD) is the leading cause of death and disability in the industrialized world, and its prevalence is rapidly increasing among developing nations. The increasing global prevalence of CVD reflects in part the concurrent rise in insulin resistance, obesity, dyslipidemia, and other atherogenic changes associated with insulin resistance syndrome (IRS). Evidence suggests that chronic stress and related psychosocial factors also play an important role in the development and progression of IRS-related states and ultimately, in the pathogenesis of CVD. Designed to address these interrelated psychological and physiological components of health, yoga and other traditional mind-body therapies may offer particular promise in both the primary and secondary prevention of CVD. In this article, we review the evidence regarding the potential benefits of specific mind-body modalities for CVD risk reduction and discuss possible mechanisms underlying these observed effects. (Ahern Ther Health Med. 2007;13(5):44-51.)
C1 [Innes, Kim E.; Taylor, Ann Gill] Univ Virginia Hlth Syst, Ctr Study Complementary & Alternat Therapies, Charlottesville, VA USA.
   [Innes, Kim E.] Univ Virginia Hlth Syst, Dept Phys Med & Rehabil, Charlottesville, VA USA.
   [Vincent, Heather K.] Univ Florida, Dept Orthoped & Rehabil, Gainesville, FL USA.
C3 University of Virginia; University of Virginia (UVA) Health System;
   University of Virginia; University of Virginia (UVA) Health System;
   State University System of Florida; University of Florida
RP Innes, KE (corresponding author), Univ Virginia Hlth Syst, Ctr Study Complementary & Alternat Therapies, Charlottesville, VA USA.
RI Vincent, Heather/ABH-4566-2020; Taylor, Ann/IQT-7642-2023
OI Vincent, Heather/0000-0003-2177-1683
FU University of Virginia Institute on Aging; National Center for
   Complementary and Alternative Medicine [T32-AT-00052, R21AT002982];
   National Center for Research Resources [M01 RR 00030-32]
FX This work was made possible by the University of Virginia Institute on
   Aging, the National Center for Complementary and Alternative Medicine
   (Grant Numbers T32-AT-00052 and R21AT002982) and the National Center for
   Research Resources (Grant Number M01 RR 00030-32. The contents are
   solely the responsibility of the authors and do not represent the
   official views of the University of Virginia or the National Institutes
   of Health.
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NR 166
TC 33
Z9 37
U1 0
U2 9
PU INNOVISION COMMUNICATIONS
PI ALISO VIEJO
PA 101 COLUMBIA, ALISO VIEJO, CA 92656 USA
SN 1078-6791
J9 ALTERN THER HEALTH M
JI Altern. Ther. Health Med.
PD SEP-OCT
PY 2007
VL 13
IS 5
BP 44
EP 51
PG 8
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA V12YN
UT WOS:000207634600010
PM 17900042
DA 2025-06-11
ER

PT J
AU Oddy, WH
   Allen, KL
   Trapp, GSA
   Ambrosini, GL
   Black, LJ
   Huang, RC
   Rzehak, P
   Runions, KC
   Pan, F
   Beilin, LJ
   Mori, TA
AF Oddy, Wendy H.
   Allen, Karina L.
   Trapp, Georgina S. A.
   Ambrosini, Gina L.
   Black, Lucinda J.
   Huang, Rae-Chi
   Rzehak, Peter
   Runions, Kevin C.
   Pan, Feng
   Beilin, Lawrence J.
   Mori, Trevor A.
TI Dietary patterns, body mass index and inflammation: Pathways to
   depression and mental health problems in adolescents
SO BRAIN BEHAVIOR AND IMMUNITY
LA English
DT Article
DE Dietary patterns; Adiposity; Leptin; hs-CRP; Depression; Raine Study
ID C-REACTIVE PROTEIN; CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME;
   YOUNG-ADULTS; INSULIN-RESISTANCE; DISORDERS; SYMPTOMS; MARKERS; WOMEN;
   ASSOCIATIONS
AB Background: Observational studies suggest that dietary patterns may impact mental health outcomes, although biologically plausible pathways are yet to be tested. We aimed to elucidate the longitudinal relationship between dietary patterns, adiposity, inflammation and mental health including depressive symptoms in a population-based cohort of adolescents.
   Methods: Data were provided from 843 adolescents participating in the Western Australian Pregnancy Cohort (Raine) Study at 14 and 17 years (y) of age. Structural equation modelling was applied to test our hypothesised models relating dietary patterns, energy intake and adiposity (body mass index) at 14 y to adiposity and the pro-inflammatory adipokine (leptin) and inflammation (high sensitivity C-reactive protein hs-CRP) at 17 y, and these inflammatory markers to depressive symptoms (Beck Depression Inventory) and Internalising and Externalising Behavioral Problems (Child Behavior Check List Youth Self-Report) at 17 y. We further tested a reverse hypothesis model, with depression at 14 y as a predictor of dietary patterns at the same time-point.
   Results: The tested models provided a good fit to the data. A 'Western' dietary pattern (high intake of red meat, takeaway, refined foods, and confectionary) at 14 y was associated with higher energy intake and BMI at 14 y, and with BMI and biomarkers of inflammation at 17 y (all p < .05). A 'Healthy' dietary pattern (high in fruit, vegetables, fish, whole-grains) was inversely associated with BMI and inflammation at 17 y (p < .05). Higher BMI at 14y was associated with higher BMI (p < .01), leptin (p < .05), hs-CRP (p < .05), depressive symptoms (p < .05) and mental health problems (p < .05), all at 17 y.
   Conclusion: A 'Western' dietary pattern associates with an increased risk of mental health problems including depressive symptoms in adolescents, through biologically plausible pathways of adiposity and inflammation, whereas a 'Healthy' dietary pattern appears protective in these pathways. Longitudinal modelling into adulthood is indicated to confirm the complex associations of dietary patterns, adiposity, inflammation and mental health problems, including depressive symptoms. (C) 2018 Elsevier Inc. All rights reserved.
C1 [Oddy, Wendy H.; Pan, Feng] Univ Tasmania, Menzies Inst Med Res, 17 Liverpool St, Hobart, Tas 7000, Australia.
   [Oddy, Wendy H.; Trapp, Georgina S. A.; Ambrosini, Gina L.; Black, Lucinda J.; Huang, Rae-Chi; Runions, Kevin C.] Univ Western Australia, Telethon Kids Inst, Perth, WA 6872, Australia.
   [Allen, Karina L.] Univ Western Australia, Sch Psychol, Nedlands, WA 6009, Australia.
   [Trapp, Georgina S. A.; Ambrosini, Gina L.] Univ Western Australia, Sch Populat & Global Hlth, Nedlands, WA 6009, Australia.
   [Black, Lucinda J.] Curtin Univ, Sch Publ Hlth, Bentley, WA 6102, Australia.
   [Rzehak, Peter] Ludwig Maximilians Univ Munchen LMU, Dr von Hauner Childrens Hosp, Div Metab & Nutr Med, Munich, Germany.
   [Beilin, Lawrence J.; Mori, Trevor A.] Univ Western Australia, Sch Med & Pharmacol, Nedlands, WA 6009, Australia.
C3 University of Tasmania; Menzies Institute for Medical Research;
   University of Western Australia; The Kids Research Institute Australia;
   University of Western Australia; University of Western Australia; Curtin
   University; University of Munich; University of Western Australia
RP Oddy, WH (corresponding author), Univ Tasmania, Menzies Inst Med Res, 17 Liverpool St, Hobart, Tas 7000, Australia.
EM Wendy.Oddy@utas.edu.au
RI Mori, Trevor/H-5485-2014; Beilin, L./I-9182-2019; Ambrosini,
   Gina/E-7107-2010; Allen, Karina/A-2273-2008; Black, Lucinda/C-1930-2015;
   Pan, Feng/AAF-8715-2020; Runions, Kevin/AAY-3828-2021; Trapp,
   Gina/AAF-9329-2020; Runions, Kevin/A-4548-2013
OI TRAPP, Gina/0009-0001-3683-0319; Mori, Trevor A/0000-0002-5264-9229;
   Beilin, Lawrence/0000-0003-4853-7360; Runions,
   Kevin/0000-0002-8770-8743; Pan, Feng/0000-0002-3403-0094; Black,
   Lucinda/0000-0003-4727-4773; Trapp, Gina/0000-0001-8529-4260
FU Heart Foundation Beyond Blue Strategic Research Program [G08P4036];
   Raine Medical Research Foundation at The University of Western
   Australia; NHMRC; Telstra Research Foundation; Western Australian Health
   Promotion Foundation; Australian Rotary Health Research Fund; Telethon
   Kids Institute; Commonwealth Scientific and Industrial Research
   Organization; NHMRC [003209, 211912, 353514, 403981, 1022134]; European
   Union [289346]
FX This work was supported by the Heart Foundation Beyond Blue Strategic
   Research Program (Oddy et al ID G08P4036 2009-2012). The Western
   Australian Pregnancy Cohort (Raine) Study received funding from the
   Raine Medical Research Foundation at The University of Western
   Australia, the NHMRC, the Telstra Research Foundation, the Western
   Australian Health Promotion Foundation and Australian Rotary Health
   Research Fund. We acknowledge the Telethon Kids Institute, the
   Commonwealth Scientific and Industrial Research Organization, the NHMRC
   Program Grant ID #003209 and Project Grant #211912 for supporting the 14
   y follow up. Data collection and biological specimens at the 17 y
   follow-up were funded by the NHMRC Program Grant ID 353514 and Project
   Grant #403981. L Black was funded on NHMRC Project #1022134 (2012-2014).
   T Mori is a NHMRC Senior Research Fellow. This project received funding
   from the European Union Seventh Framework Programme (FP7/2007-2013)
   under grant agreement no 289346. Professor Oddy received an
   International Fellowship to the Centre for Advanced Studies, University
   of Munich, January to March 2013 to work with P Rzehak on
   conceptualisation of the project. All authors declare that there are no
   potential or existing conflicts of interest.
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NR 77
TC 116
Z9 126
U1 2
U2 61
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0889-1591
EI 1090-2139
J9 BRAIN BEHAV IMMUN
JI Brain Behav. Immun.
PD MAR
PY 2018
VL 69
BP 428
EP 439
DI 10.1016/j.bbi.2018.01.002
PG 12
WC Immunology; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Immunology; Neurosciences & Neurology; Psychiatry
GA GG7VB
UT WOS:000432905200039
PM 29339318
OA Green Accepted, Green Submitted
DA 2025-06-11
ER

PT J
AU Palar, K
   Hufstedler, EL
   Hernandez, K
   Chang, A
   Ferguson, L
   Lozano, R
   Weiser, SD
AF Palar, Kartika
   Lemus Hufstedler, Emiliano
   Hernandez, Karen
   Chang, Annie
   Ferguson, Laura
   Lozano, Raul
   Weiser, Sheri D.
TI Nutrition and Health Improvements After Participation in an Urban Home
   Garden Program
SO JOURNAL OF NUTRITION EDUCATION AND BEHAVIOR
LA English
DT Article
DE health; Latino; nutrition; qualitative; urban garden
ID CARDIOMETABOLIC RISK; COMMUNITY GARDENS; FOOD INSECURITY; UNITED-STATES;
   PREVALENCE; OBESITY; PERSPECTIVES; VEGETABLES; SECURITY; BENEFITS
AB Objective: To elucidate the perceived health benefits of an urban home gardening and nutritional education program in a population at high cardiometabolic risk.
   Design: Qualitative data collected via in-depth, semistructured interviews in Spanish or English.
   Setting: Community-based program offering supported urban home gardening together with nutrition education in Santa Clara County, CA.
   Participants: A total of 32 purposively sampled low-income participants in an urban home gardening program. Participants were primarily female (n = 24) and Latino/a (n = 22).
   Phenomenon of Interest: Perceptions of the nutrition and health benefits of education-enhanced urban home gardening.
   Analysis: Bilingual researchers coded transcripts using a hybrid inductive and deductive approach. Two coders double coded at intervals, independently reviewed coding reports, organized content into key themes, and selected exemplary quotations.
   Results: The most salient perceived impacts were greater food access, increased consumption of fresh produce, a shift toward home cooking, and decreased fast food consumption. Participants attributed these changes to greater affordability, freshness, flavor, and convenience of their garden produce; increased health motivation owing to pride in their gardens; and improved nutritional knowledge. Participants also reported improved physical activity, mental health, and stress management; some reported improved weight and adherence to diabetes-healthy diets.
   Conclusions and Implications: Education-enhanced urban home gardening may facilitate multidimensional nutrition and health improvements in marginalized populations at high cardiometabolic risk.
C1 [Palar, Kartika; Lemus Hufstedler, Emiliano; Weiser, Sheri D.] Univ Calif San Francisco, Div HIV Infect Dis & Global Med, San Francisco, CA 94143 USA.
   [Lemus Hufstedler, Emiliano; Chang, Annie] Univ Calif Berkeley, Sch Publ Hlth, UCSF Joint Med Program, Berkeley, CA 94720 USA.
   [Hernandez, Karen] Univ British Columbia, Fac Med, Vancouver, BC, Canada.
   [Ferguson, Laura] Univ Calif San Francisco, Global Hlth Sci, San Francisco, CA 94143 USA.
   [Lozano, Raul] Valley Verde, San Jose, CA USA.
   [Weiser, Sheri D.] Univ Southern Calif, Keck Sch Med, Inst Global Hlth, Los Angeles, CA USA.
C3 University of California System; University of California San Francisco;
   University of California System; University of California Berkeley;
   University of British Columbia; University of California System;
   University of California San Francisco; University of Southern
   California
RP Palar, K (corresponding author), UCSF San Francisco Gen Hosp, Div HIV Infect Dis & Global Med, 995 Potrero Ave,Bldg 80,Ward 84,Campus Box 0874, San Francisco, CA 94110 USA.
EM kartika.palar@ucsf.edu
RI Ferguson, Laura/AAO-9694-2021
FU Center for Collaborative Research for an Equitable California at the
   University of California; National Institute of Diabetes and Digestive
   and Kidney Diseases grant [K01DK107335]
FX This work was supported by the Center for Collaborative Research for an
   Equitable California at the University of California. Further salary
   support (Palar) was provided by National Institute of Diabetes and
   Digestive and Kidney Diseases grant K01DK107335. The authors thank the
   Valley Verde staff for their invaluable support during this study. They
   thank the Valley Verde study participants for sharing their time and
   experiences as part of this research.
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NR 50
TC 36
Z9 37
U1 7
U2 72
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1499-4046
EI 1878-2620
J9 J NUTR EDUC BEHAV
JI J. Nutr. Educ. Behav.
PD OCT
PY 2019
VL 51
IS 9
BP 1037
EP 1046
DI 10.1016/j.jneb.2019.06.028
PG 10
WC Education, Scientific Disciplines; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Education & Educational Research; Nutrition & Dietetics
GA JC3GP
UT WOS:000489167400003
PM 31601420
OA Green Accepted, Green Submitted
DA 2025-06-11
ER

PT J
AU Guariente, SMM
   Oliveira, ACN
   Mesas, AE
   Oliveira, CEC
   Reiche, EMV
   Zazula, R
   Nunes, SOV
AF Guariente, Suzana Maria Menezes
   Oliveira, Ana Cecilia Novaes
   Mesas, Arthur Eumann
   Oliveira, Carlos Eduardo Coral
   Reiche, Edna Maria Vissosi
   Zazula, Robson
   Nunes, Sandra Odebrecht Vargas
TI Psychosocial hybrid interventions for weight and sedentary behavior
   management among patients with severe mental disorders: A systematic
   review and meta-analysis
SO JOURNAL OF PSYCHIATRIC RESEARCH
LA English
DT Review
DE Severe mental disorders; Weight loss; Metabolic syndrome; Psychosocial
   intervention; Hybrid intervention; e-health; Face-to-face intervention;
   Systematic review; Meta-analysis
ID LIFE-STYLE INTERVENTION; MIDDLE-INCOME COUNTRIES; METABOLIC SYNDROME;
   MOBILE HEALTH; SCHIZOPHRENIA; TECHNOLOGY; INDIVIDUALS; ILLNESS;
   FEASIBILITY; MEDICATIONS
AB Background: Severe mental disorders, such as schizophrenia, bipolar disorders, and other psychosis have been associated with risk of premature mortality, predominantly due to cardiovascular diseases and metabolic syndrome. The aim of this systematic review and meta-analysis was to examine the efficacy of hybrid psychosocial interventions combining face-to-face and eHealth components for patients with severe mental disorders on reduction of weight and waist circumference. Method: The electronic search on PubMED, PsycINFO, EMBASE, Web of Science were conducted, and data were extracted twice. A supplementary search was also conducted. Interventions with severe mental disorder patients reporting outcomes related to obesity, metabolism, metabolic syndrome, and inflammation were included. Data were synthesized using a systematic narrative synthesis framework, and formal quality assessments to address the risk of bias. A meta-analysis was also conducted. Results: After following the steps recommended by PRISMA statements, 14 studies were included in the systematic review and four studies were included in meta-analysis. The pooled analysis demonstrated that hybrid interventions were not able to significantly promote waist circumference changes [SMD (cm) =-0.19, 95% CI =-0.60, 0.22; Z = 0.91; p = 0.36; two studies] nor weight reduction [SMD (kg) =-0.21, 95% CI =-0.43, 0.01; Z = 1.90; p = 0.06; four studies] in patients with severe mental disorders. Conclusion: More studies should focus on hybrid mental health psychosocial for weight control and sedentary lifestyle need to be elaborated to verify their effectiveness in improving sedentary lifestyle and promoting weight reduction in people with severe mental disorders.
C1 [Guariente, Suzana Maria Menezes; Oliveira, Ana Cecilia Novaes; Reiche, Edna Maria Vissosi; Zazula, Robson; Nunes, Sandra Odebrecht Vargas] Univ Estadual Londrina, Hlth Sci Ctr, Hlth Sci Postgrad Program, Londrina, PR, Brazil.
   [Mesas, Arthur Eumann] Univ Castilla La Mancha, La Mancha, Spain.
   [Oliveira, Carlos Eduardo Coral] Pontif Catholic Univ, Curitiba, PR, Brazil.
   [Zazula, Robson] Fed Univ Latin American Integrat, Foz Do Iguacu, PR, Brazil.
C3 Universidade Estadual de Londrina; Universidad de Castilla-La Mancha;
   Pontificia Universidade Catolica do Parana
RP Guariente, SMM (corresponding author), Univ Estadual Londrina, Hlth Sci Ctr, Hlth Sci Postgrad Program, Londrina, PR, Brazil.
EM suzana.guariente@uel.br
RI Zazula, Robson/LPP-8373-2024; Reiche, Edna/C-4102-2013; Mesas,
   Arthur/AAK-3361-2021
OI Mesas, Arthur/0000-0002-0088-8607
FU Coordination for the Improvement of Higher Level of Education Personnel
   (CAPES) of Brazilian Ministry of Education [001]
FX We thank the Coordination for the Improvement of Higher Level of
   Education Personnel (CAPES) of Brazilian Ministry of Education: Finance
   Code 001.
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NR 45
TC 0
Z9 0
U1 2
U2 2
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-3956
EI 1879-1379
J9 J PSYCHIATR RES
JI J. Psychiatr. Res.
PD JAN
PY 2025
VL 181
BP 391
EP 399
DI 10.1016/j.jpsychires.2024.11.039
EA DEC 2024
PG 9
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA P4F1H
UT WOS:001377477400001
PM 39647351
DA 2025-06-11
ER

PT J
AU Bahadoran, Z
   Golzarand, M
   Mirmiran, P
   Saadati, N
   Azizi, F
AF Bahadoran, Z.
   Golzarand, M.
   Mirmiran, P.
   Saadati, N.
   Azizi, F.
TI The association of dietary phytochemical index and cardiometabolic risk
   factors in adults: Tehran Lipid and Glucose Study
SO JOURNAL OF HUMAN NUTRITION AND DIETETICS
LA English
DT Article
DE cardiometabolic risk factors; phytochemical index; Tehran Lipid and
   Glucose Study
ID CORONARY-HEART-DISEASE; METABOLIC SYNDROME; OXIDATIVE STRESS;
   CARDIOVASCULAR-DISEASE; INSULIN-RESISTANCE; CONSUMPTION; PREVALENCE;
   INFLAMMATION; POPULATION; PREVENTION
AB Background Phytochemicals are natural non-nutritive bioactive compounds found in fruits, vegetables, whole grains, nuts and legumes, as well as other plant foods. In the present study, we assessed the dietary phytochemical index (PI) in relation to cardiometabolic risk factors among Iranian adults. Methods This cross-sectional study was conducted within the framework of third phase of Tehran Lipid and Glucose Study 2006-2008. For the present study, 2567 subjects aged 19-70 years (1129 men and 1438 women) were selected randomly. Dietary data were collected using a validated semi-quantitative food frequency questionnaire with 168 food items. The PI was calculated based on daily energy derived from phytochemical-rich foods. The odds ratios of abdominal obesity, impaired fasting glucose, hypertriglyceridaemia, low high-density lipoprotein-cholesterol and hypertension were assessed across PI quartile categories. Results The mean (SD) age of participants was 39.4(13.2)years. Participants in the upper quartile of PI were older, and had a lower weight and waist circumference. The mean (SD) of the PI was 17.3 (5.6), 25.5 (6.4), 32.7 (8.3) and 42.8 (10.5) in the first, second, third and fourth quartiles, respectively. Compared with those in the lower quartile of PI, participants in the upper quartiles had a 66% lower risk of abdominal obesity [95% confidence interval (CI)=0.23-0.51] and a 36% lower risk of hypertriglyceridaemia (95% CI, 0.47-0.86), after adjustment for potential confounders. Conclusions Higher intakes of phytochemical-rich foods are associated with a lower risk of abdominal obesity and hypertriglyceridaemia as the main cardiometabolic risk factors.
C1 [Bahadoran, Z.; Golzarand, M.; Saadati, N.] Shahid Beheshti Univ Med Sci, Res Inst Endocrine Sci, Obes Res Ctr, Tehran, Iran.
   [Mirmiran, P.] Shahid Beheshti Univ Med Sci, Natl Nutr & Food Technol Res Inst, Fac Nutr Sci & Food Technol, Dept Nutr & Clin Dietet, Tehran, Iran.
   [Azizi, F.] Shahid Beheshti Univ Med Sci, Res Inst Endocrine Sci, Endocrine Res Ctr, Tehran, Iran.
C3 Shahid Beheshti University Medical Sciences; Shahid Beheshti University
   Medical Sciences; Shahid Beheshti University Medical Sciences
RP Mirmiran, P (corresponding author), Shahid Beheshti Univ Med Sci, Natl Nutr & Food Technol Res Inst, Fac Nutr Sci & Food Technol, Dept Nutr & Clin Dietet, 46 Arghavan E Gharbi St,Farahzadi Blv,POB 19395-4, Tehran, Iran.
EM mirmiran@endocrine.ac.ir
RI Mirmiran, Parvin/V-1433-2019; Bahadoran, Zahra/V-2003-2019; Golzarand,
   Mahdieh/E-4055-2018; Azizi, Fereidoun/ABD-4136-2021
OI Golzarand, Mahdieh/0000-0003-2651-9276; Azizi,
   Fereidoun/0000-0002-6470-2517; Mirmiran, Parvin/0000-0003-2391-4924
FU National Research Council of the Islamic Republic of Iran [121];
   Research Institute for Endocrine Sciences of Shahid Beheshti University
   of Medical Sciences
FX The authors declare that there are no conflicts of interest. The present
   study was supported by grant no. 121 from the National Research Council
   of the Islamic Republic of Iran and the Research Institute for Endocrine
   Sciences of Shahid Beheshti University of Medical Sciences.
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NR 36
TC 60
Z9 61
U1 0
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0952-3871
EI 1365-277X
J9 J HUM NUTR DIET
JI J. Hum. Nutr. Diet.
PD JUL
PY 2013
VL 26
SU 1
SI SI
BP 145
EP 153
DI 10.1111/jhn.12048
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 168RE
UT WOS:000320722400019
PM 23581519
DA 2025-06-11
ER

PT J
AU Chen, E
   Yu, TY
   Ehrlich, KB
   Lam, PH
   Jiang, T
   Mcdade, TW
   Miller, GE
   Brody, GH
AF Chen, Edith
   Yu, Tianyi
   Ehrlich, Katherine B.
   Lam, Phoebe H.
   Jiang, Tao
   Mcdade, Thomas W.
   Miller, Gregory E.
   Brody, Gene H.
TI Family Disadvantage, Education, and Health Outcomes Among Black Youths
   Over a 20-Year Period
SO JAMA NETWORK OPEN
LA English
DT Article
ID COLORECTAL-CANCER
AB Importance Upward mobility (via educational attainment) is highly valued, but longitudinal associations with mental and physical health among Black youths are less understood. Objective To examine associations of childhood family disadvantage and college graduation with adult mental and physical health in Black youths followed up into adulthood. Design, Setting, and Participants This longitudinal, prospective cohort study of Black youths from the state of Georgia who were studied for 20 years (ages 11 to 31 years) was conducted between 2001 and 2022. Participants for this study were drawn from the Strong African American Healthy Adults Program. Data analysis was conducted from April 2023 to January 2024. Exposures Family economic disadvantage (measured during the adolescent years) and college graduation (indicating upward mobility). Main Outcomes and Measures Primary outcomes included mental health, substance use, and physical health. Mental health included a composite of internalizing and disruptive problems (anxiety, depression, anger, aggressive behaviors, and emotional reactivity). Substance use included a composite of smoking, drinking, and drug use. Physical health included metabolic syndrome (MetS) and proinflammatory phenotypes (immune cells mounting exaggerated cytokine responses to bacterial challenge and being insensitive to inhibitory signals from glucocorticoids). Mental and physical health measures were taken at age 31 and during the adolescent years. Linear and logistic regression analyses, as well as mediated moderation analyses, were conducted. Results The study population consisted of 329 Black youths (212 women [64%]; 117 men [36%]; mean [SD] age at follow-up, 31 [1] years). Compared with those who did not graduate college, those who graduated from college had 0.14 SD fewer mental health problems (b = -1.377; 95% CI, -2.529 to -0.226; beta = -0.137; P = .02) and 0.13 SD lower levels of substance use (b = -0.114; 95% CI, -0.210 to -0.018; beta = -0.131; P = .02). Residualized change scores revealed that college graduates showed greater decreases from age 16 to 31 years in mental health problems (b = -1.267; 95% CI, -2.360 to -0.174; beta = -0.133; P = .02) and substance use problems (b = -0.116; 95% CI, -0.211 to -0.021; beta = -0.136; P = .02). For physical health, significant interactions between childhood family disadvantage and college completion emerged in association with MetS (OR, 1.495; 95% CI, 1.111-2.012; P = .008) and proinflammatory phenotype (b = 0.051; 95% CI, 0.003 to 0.099; beta = 0.131; P = .04). Among youths growing up in disadvantaged households, college completion was associated with a 32.6% greater likelihood of MetS (OR, 3.947; 95% CI, 1.003-15.502; P = .049) and 0.59 SD more proinflammatory phenotype (mean difference, 0.249, 95% CI, 0.001 to 0.497; P = .049). Conversely, among those from economically advantaged backgrounds, college completion was correlated with lower MetS and less proinflammatory phenotype. Findings held after controlling for body mass index at age 19 years. Conclusions and Relevance In this longitudinal cohort study of Black youths, graduating from college was associated with an adult profile of better mental health but poorer physical health among those from economic disadvantage. These findings suggest that developing interventions that foster healthy outcomes across multiple life domains may be important for ensuring that striving for upward mobility is not accompanied by unintended cardiometabolic risk.
C1 [Chen, Edith] Northwestern Univ, Inst Policy Res, 2029 Sheridan Rd, Evanston, IL 60208 USA.
   [Chen, Edith; Jiang, Tao; Mcdade, Thomas W.; Miller, Gregory E.] Northwestern Univ, Inst Policy Res, Evanston, IL USA.
   [Chen, Edith; Jiang, Tao; Miller, Gregory E.] Northwestern Univ, Dept Psychol, Evanston, IL USA.
   [Yu, Tianyi; Ehrlich, Katherine B.; Brody, Gene H.] Univ Georgia, Ctr Family Res, Athens, GA USA.
   [Ehrlich, Katherine B.] Univ Georgia, Dept Psychol, Athens, GA USA.
   [Lam, Phoebe H.] Carnegie Mellon Univ, Dept Psychol, Pittsburgh, PA USA.
   [Mcdade, Thomas W.] Northwestern Univ, Dept Anthropol, Evanston, IL USA.
C3 Northwestern University; Northwestern University; Northwestern
   University; University System of Georgia; University of Georgia;
   University System of Georgia; University of Georgia; Carnegie Mellon
   University; Northwestern University
RP Chen, E (corresponding author), Northwestern Univ, Inst Policy Res, 2029 Sheridan Rd, Evanston, IL 60208 USA.
EM edith.chen@northwestern.edu
OI McDade, Thomas/0000-0001-5829-648X; Miller, Gregory/0000-0002-7217-1082
FU National Institutes of Health [HD030588, HD093718, DA051361]
FX This research was supported by the National Institutes of Health (grants
   HD030588, HD093718, and DA051361 to Drs Chen and Brody).
CR Andersen SW, 2019, JAMA NETW OPEN, V2, DOI 10.1001/jamanetworkopen.2019.17995
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NR 6
TC 1
Z9 1
U1 1
U2 2
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 2574-3805
J9 JAMA NETW OPEN
JI JAMA Netw. Open
PD MAR 29
PY 2024
VL 7
IS 3
AR e242289
DI 10.1001/jamanetworkopen.2024.2289
PG 13
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA MM0V1
UT WOS:001193929200004
PM 38551566
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Tzellos, T
   Zouboulis, CC
AF Tzellos, Thrasyvoulos
   Zouboulis, Christos C.
TI Which hidradenitis suppurativa comorbidities should I take into account?
SO EXPERIMENTAL DERMATOLOGY
LA English
DT Review
DE clinical significance; comorbidities; depression; hidradenitis
   suppurativa; inflammatory bowel disease; metabolic syndrome; quality of
   life; working disability
AB Hidradenitis suppurativa (HS) is a chronic, recurrent skin inflammatory disease associated with a variety of comorbidities, like metabolic syndrome, reduced quality of life, sexual dysfunction, working disability, inflammatory bowel disease, axial spondyloarthritis, depression and anxiety. Like psoriasis, HS patients have been found to have higher risk of cardiovascular death and suicide risk. Evidence suggests that for such a chronic, multi-comorbid disease, the use of validated outcomes to assess severity and effect of treatment, along with the use of clinically important patient reported outcomes, is essential. Clinicians should be informed about these comorbidities so that appropriate screening is implemented. The potential of available treatments to negatively and positively affect these comorbidities should also be taken into account when designing treatment strategies. This article aims to provide an outline of important HS comorbidities with emphasis on possible implications for daily clinical practice.
C1 [Tzellos, Thrasyvoulos; Zouboulis, Christos C.] European Hidradenitis Suppurat Fdn eV, Dessau, Germany.
   [Tzellos, Thrasyvoulos] Arctic Univ, Inst Clin Med, Tromso, Norway.
   [Zouboulis, Christos C.] Brandenburg Med Sch Theodor Fontane, Dept Dermatol, Dessau Med Ctr, Dessau, Germany.
   [Zouboulis, Christos C.] Brandenburg Med Sch Theodor Fontane, Dept Venereol, Dessau Med Ctr, Dessau, Germany.
   [Zouboulis, Christos C.] Brandenburg Med Sch Theodor Fontane, Dept Allergol, Dessau Med Ctr, Dessau, Germany.
   [Zouboulis, Christos C.] Brandenburg Med Sch Theodor Fontane, Dept Immunol, Dessau Med Ctr, Dessau, Germany.
   [Zouboulis, Christos C.] Fac Hlth Sci Brandenburg, Dessau, Germany.
C3 UiT The Arctic University of Tromso; Dessau Medical Center; Dessau
   Medical Center; Dessau Medical Center; Dessau Medical Center
RP Tzellos, T (corresponding author), Arctic Univ, Inst Clin Med, Tromso, Norway.
EM ltzellos@gmail.com
RI Prof. Dr. Zouboulis, Christos/I-4493-2013
OI Prof. Dr. Zouboulis, Christos/0000-0003-1646-2608
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NR 29
TC 16
Z9 15
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0906-6705
EI 1600-0625
J9 EXP DERMATOL
JI Exp. Dermatol.
PD SEP
PY 2022
VL 31
SU 1
BP 29
EP 32
DI 10.1111/exd.14633
EA JUL 2022
PG 4
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 4H2FO
UT WOS:000820196200001
PM 35737874
OA Bronze
DA 2025-06-11
ER

PT J
AU Sheesley, AP
AF Sheesley, Alison Phillips
TI Counselors Within the Chronic Care Model: Supporting Weight Management
SO JOURNAL OF COUNSELING AND DEVELOPMENT
LA English
DT Article
DE obesity; Chronic Care Model; integrated care; wellness; counselor
ID BINGE-EATING DISORDER; IMPROVING PRIMARY-CARE; METABOLIC SYNDROME; FOOD
   ADDICTION; UNITED-STATES; BODY-WEIGHT; CHRONIC ILLNESS; OBESITY;
   DEPRESSION; METAANALYSIS
AB The Chronic Care Model developed for the multidisciplinary management of chronic diseases provides a blueprint for the integrated role of mental health counselors supporting clients with obesity seeking weight management treatment. Counselors can support clients and the team of health care professionals treating obesity within each of the 6 components of the model: (a) health care organization, (b) delivery-system design, (c) clinical information systems, (d) decision support, (e) client self-management support, and (f) community resources.
C1 [Sheesley, Alison Phillips] Univ No Colorado, Dept Appl Psychol & Counselor Educ, Campus Box 131, Greeley, CO 80639 USA.
C3 University of Northern Colorado
RP Sheesley, AP (corresponding author), Univ No Colorado, Dept Appl Psychol & Counselor Educ, Campus Box 131, Greeley, CO 80639 USA.
EM PHIL1636@bears.unco.edu
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NR 107
TC 1
Z9 6
U1 0
U2 8
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0748-9633
EI 1556-6676
J9 J COUNS DEV
JI J. Couns. Dev.
PD APR
PY 2016
VL 94
IS 2
BP 234
EP 245
DI 10.1002/jcad.12079
PG 12
WC Psychology, Applied
WE Social Science Citation Index (SSCI)
SC Psychology
GA DG2JS
UT WOS:000371893800010
DA 2025-06-11
ER

PT J
AU Costemale-Lacoste, JF
   El Asmar, K
   Rigal, A
   Martin, S
   Tayeb, AA
   Colle, R
   Becquemont, L
   Fève, B
   Corruble, E
AF Costemale-Lacoste, Jean-Francois
   El Asmar, Khalil
   Rigal, Adrien
   Martin, Severine
   Tayeb, Abd El Kader Ait
   Colle, Romain
   Becquemont, Laurent
   Feve, Bruno
   Corruble, Emmanuelle
TI Severe insomnia is associated with metabolic syndrome in women over 50
   years with major depression treated in psychiatry settings: a METADAP
   report
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE MDD; MDE; Insomnia; Severe insomnia; Cardiovascular risk; Metabolic
   syndrome
ID CORONARY-HEART-DISEASE; SHORT-SLEEP DURATION; CARDIOVASCULAR-DISEASE;
   EPIDEMIOLOGIC EVIDENCE; SEX-DIFFERENCES; RISK; METAANALYSIS; PREVALENCE;
   MORTALITY; SCALE
AB Introduction: Major depression is associated with metabolic syndrome and cardiovascular risk. We have previously shown that severe insomnia, a core symptom of major depression episode (MDE), is associated with hypertriglyceridemia, a component of metabolic syndrome, in women but not in men with major depression. Since insomnia is related to cardiovascular morbidity in the general population and major depression also, our objective was to assess the link between insomnia and metabolic syndrome, a marker syndrome of cardiovascular risk, during MDE, in women and in men.
   Methods: In 624 patients with a current MDE cohort, both insomnia and metabolic syndrome were assessed in women and men. Insomnia was rated from 0 to 6 based on the HDRS corresponding items, severe insomnia being defined by a total insomnia score >4.
   Results: severe insomnia was associated with metabolic syndrome in women but not in men. In multivariate logistic regressions, these results in women were independent from age, educational level, major depressive disorder duration and current smoking. These results were only significant in women aged >= 50 years, a cut-off age for menopausal status but not in women under 50 years.
   Conclusion: Women aged >= 50 years with a severe insomnia during MDE have an increased risk of metabolic syndrome. Severe insomnia may be a clinical marker of metabolic risk in this population. They should be particularly monitored for metabolic syndrome and may benefit from sleep recommendations and cardiovascular prevention.
C1 [Costemale-Lacoste, Jean-Francois; El Asmar, Khalil; Rigal, Adrien; Martin, Severine; Tayeb, Abd El Kader Ait; Colle, Romain; Becquemont, Laurent; Corruble, Emmanuelle] CESP, INSERM, UMR 1178, Equipe Depress Le Kremlin Bicetre, F-94276 Levallois Perret, France.
   [Costemale-Lacoste, Jean-Francois; El Asmar, Khalil; Rigal, Adrien; Martin, Severine; Tayeb, Abd El Kader Ait; Colle, Romain; Becquemont, Laurent; Corruble, Emmanuelle] Univ Paris Sud, Fac Med Paris Sud, F-94276 Le Kremlin Bicetre, France.
   [El Asmar, Khalil] Amer Univ Beirut, Fac Hlth Sci, Dept Epidemiol & Populat Hlth, POB 11-0236, Beirut 11072020, Lebanon.
   [Rigal, Adrien; Martin, Severine; Tayeb, Abd El Kader Ait; Colle, Romain; Becquemont, Laurent; Corruble, Emmanuelle] Hop Univ Paris Sud, AP HP, F-94275 Le Kremlin Bicetre, France.
   [Rigal, Adrien; Martin, Severine; Tayeb, Abd El Kader Ait; Colle, Romain; Corruble, Emmanuelle] Hop Bicetre, Serv Hosp Univ Psychiat, F-94275 Le Kremlin Bicetre, France.
   [Becquemont, Laurent] Hop Bicetre, Serv Genet Mol Pharmacogenet & Hormonol, F-94275 Le Kremlin Bicetre, France.
   [Feve, Bruno] Sorbonne Univ, INSERM, UMR S 938, Ctr Rech St Antoine,Inst Hosp Univ ICAN, F-75012 Paris, France.
   [Feve, Bruno] Hop St Antoine, AP HP, Serv Endocrinol, F-75012 Paris, France.
C3 Universite Paris Cite; Institut National de la Sante et de la Recherche
   Medicale (Inserm); Universite Paris Saclay; American University of
   Beirut; Assistance Publique Hopitaux Paris (APHP); Hopital Universitaire
   Bicetre - APHP; Universite Paris Saclay; Universite Paris Saclay;
   Assistance Publique Hopitaux Paris (APHP); Hopital Universitaire
   Antoine-Beclere - APHP; Hopital Universitaire Bicetre - APHP; Universite
   Paris Saclay; Assistance Publique Hopitaux Paris (APHP); Hopital
   Universitaire Bicetre - APHP; Hopital Universitaire Antoine-Beclere -
   APHP; Sorbonne Universite; Institut National de la Sante et de la
   Recherche Medicale (Inserm); Assistance Publique Hopitaux Paris (APHP);
   Sorbonne Universite; Hopital Universitaire Saint-Antoine - APHP
RP Corruble, E (corresponding author), Hop Bicetre, Serv Hosp Univ Psychiat Bicetre, 78 Rue Gen Leclerc, F-94275 Le Kremlin Bicetre, France.
EM mmanuelle.corruble@aphp.fr
RI becquemont, laurent/KLD-8162-2024; Colle, Romain/IQV-1876-2023;
   COSTEMALE-LACOSTE, Jean-François/ABG-5308-2020
OI AIT TAYEB, Abd El Kader/0000-0001-6432-1098; Colle,
   Romain/0000-0002-2549-4495
FU French ministry of Health [AOM06022]
FX The French ministry of Health gave us grant to conduct the study through
   the National Hospital Clinical Research Program (number AOM06022).
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NR 58
TC 13
Z9 13
U1 0
U2 11
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD MAR 1
PY 2020
VL 264
BP 513
EP 518
DI 10.1016/j.jad.2019.11.084
PG 6
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA KH1BD
UT WOS:000510380300067
PM 32056777
OA Bronze
DA 2025-06-11
ER

PT J
AU Ballin, M
   Lundberg, E
   Sörlén, N
   Nordström, P
   Hult, A
   Nordström, A
AF Ballin, Marcel
   Lundberg, Emmy
   Sorlen, Niklas
   Nordstrom, Peter
   Hult, Andreas
   Nordstrom, Anna
TI Effects of interval training on quality of life and cardiometabolic risk
   markers in older adults: a randomized controlled trial
SO CLINICAL INTERVENTIONS IN AGING
LA English
DT Article
DE exercise; ageing; perceived health; blood lipids
ID DENSITY-LIPOPROTEIN CHOLESTEROL; RESTING BLOOD-PRESSURE;
   PHYSICAL-ACTIVITY; AEROBIC EXERCISE; HEART-RATE; MYOCARDIAL-INFARCTION;
   METABOLIC SYNDROME; GLOBAL BURDEN; 52 COUNTRIES; WEIGHT-LOSS
AB Purpose: To explore the effects of 10 weeks of progressive vigorous interval training as a single intervention on health-related quality of life (HRQoL) and cardiometabolic risk markers in centrally obese 70-year-old individuals.
   Participants and methods: A randomized controlled trial (ClinicalTrials.gov registration no. NCT03450655) including seventy-seven community-dwelling 70-year-old men and women with central obesity defined as > 1 kg visceral adipose tissue for women and > 2 kg for men. Participants randomized to the intervention group were offered a 10-week progressive vigorous interval training program performed three times per week. Control subjects were asked to maintain their daily living and routines throughout the trial. All participants in both groups had received tailored lifestyle recommendations focused on diet and physical activity at one occasion within 12 months prior to trial initiation. Prespecified outcome measures included: changes in HRQoL using the Short Form Health Survey Questionnaire (SF-36), blood pressure; resting heart rate (HR) and blood lipids. All analyses were conducted on an intention-to-treat basis.
   Results: The intervention resulted in significant effects on the SF-36 mental component summary (MCS) score and the mental health (MH) subscale (P< 0.05 for both), when compared to the control group. Specifically, the intervention group increased their MCS score by 6.3 points (95% confidence interval [CI] = 0.3-12.3) and their MH score by 6.0 points (95% CI = 1.7-10.4) compared to the control group. Moreover, significant effects were seen on resting HR, total cholesterol and LDL-cholesterol (P<0.05 for all).
   Conclusion: It was shown that 10 weeks of vigorous interval training as a single intervention was sufficient to improve mental aspects of HRQoL in older individuals with central obesity, which is a critical aspect of healthy ageing. Positive effects were seen also on cardiometabolic risk markers.
C1 [Ballin, Marcel; Lundberg, Emmy; Sorlen, Niklas; Nordstrom, Peter] Umea Univ, Dept Community Med & Rehabil, Unit Geriatr Med, Umea, Sweden.
   [Ballin, Marcel; Lundberg, Emmy; Sorlen, Niklas; Hult, Andreas; Nordstrom, Anna] Umea Univ, Dept Publ Hlth & Clin Med, Sect Sustainable Hlth, S-90185 Umea, Sweden.
   [Nordstrom, Anna] Arctic Univ Norway, Sch Sport Sci, Dept Sport Sci, Tromso, Norway.
C3 Umea University; Umea University; UiT The Arctic University of Tromso
RP Nordström, A (corresponding author), Umea Univ, Dept Publ Hlth & Clin Med, Sect Sustainable Hlth, S-90185 Umea, Sweden.
EM anna.h.nordstrom@umu.se
RI Nordström, Peter/F-2466-2010; Nordstrom, Anna/F-2238-2010
OI Nordstrom, Anna/0000-0003-3534-456X; Ballin, Marcel/0000-0002-9638-7208;
   Hult, Andreas/0000-0002-4341-1745
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NR 58
TC 16
Z9 18
U1 0
U2 12
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
EI 1178-1998
J9 CLIN INTERV AGING
JI Clin. Interv. Aging
PY 2019
VL 14
BP 1589
EP 1599
DI 10.2147/CIA.S213133
PG 11
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA IW1VG
UT WOS:000484757900001
PM 31564841
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Suglia, SF
   Appleton, AA
   Bleil, ME
   Campo, RA
   Dube, SR
   Fagundes, CP
   Heard-Garris, NJ
   Johnson, SB
   Slopen, N
   Stoney, CM
   Watamura, SE
AF Suglia, Shakira F.
   Appleton, Allison A.
   Bleil, Maria E.
   Campo, Rebecca A.
   Dube, Shanta R.
   Fagundes, Christopher P.
   Heard-Garris, Nia J.
   Johnson, Sara B.
   Slopen, Natalie
   Stoney, Catherine M.
   Watamura, Sarah E.
TI Timing, duration, and differential susceptibility to early life
   adversities and cardiovascular disease risk across the lifespan:
   Implications for future research
SO PREVENTIVE MEDICINE
LA English
DT Article
ID BODY-MASS INDEX; CUMULATIVE SOCIAL RISK; CHILDHOOD EXPERIENCES;
   BLOOD-PRESSURE; METABOLIC-SYNDROME; PHYSICAL HEALTH; YOUNG ADULTHOOD;
   MENTAL-HEALTH; INFLAMMATORY REACTIVITY; SOCIOECONOMIC-STATUS
AB Early life adversities (ELA), include experiences such as child maltreatment, household dysfunction, bullying, exposure to crime, discrimination, bias, and victimization, and are recognized as social determinants of cardiovascular disease (CVD). Strong evidence shows exposure to ELA directly impacts cardiometabolic risk in adulthood and emerging evidence suggests there may be continuity in ELA's prediction of cardiometabolic risk over the life course.
   Extant research has primarily relied on a cumulative risk framework to evaluate the relationship between ELA and CVD. In this framework, risk is considered a function of the number of risk factors or adversities that an individual was exposed to across developmental periods. The cumulative risk exposure approach treats developmental periods and types of risk as equivalent and interchangeable. Moreover, cumulative risk models do not lend themselves to investigating the chronicity of adverse exposures or consider individual variation in susceptibility, differential contexts, or adaptive resilience processes, which may modify the impact of ELA on CVD risk.
   To date, however, alternative models have received comparatively little consideration. Overall, this paper will highlight existing gaps and offer recommendations to address these gaps that would extend our knowledge of the relationship between ELA and CVD development. We focus specifically on the roles of: 1) susceptibility and resilience, 2) timing and developmental context; and 3) variation in risk exposure. We propose to expand current conceptual models to incorporate these factors to better guide research that examines ELA and CVD risk across the life course.
C1 [Suglia, Shakira F.] Emory Univ, Dept Epidemiol, Atlanta, GA 30322 USA.
   [Appleton, Allison A.] SUNY Albany, Sch Publ Hlth, Dept Epidemiol & Biostat, Albany, NY 12222 USA.
   [Bleil, Maria E.] Univ Washington, Dept Child Family & Populat Hlth Nursing, Seattle, WA 98195 USA.
   [Campo, Rebecca A.; Stoney, Catherine M.] NHLBI, NIH, Bldg 10, Bethesda, MD 20892 USA.
   [Dube, Shanta R.] Wingate Univ, Levine Coll Hlth Sci, Publ Hlth Program, Wingate, NC USA.
   [Fagundes, Christopher P.] Univ Texas MD Anderson Canc Ctr, Rice Univ, Baylor Coll Med, Dept Psychol Sci,Dept Behav Sci,Dept Psychiat, Houston, TX 77030 USA.
   [Heard-Garris, Nia J.] Ann & Robert H Lurie Childrens Hosp Chicago, Dept Pediat, Div Adv Gen Pediat, Chicago, IL 60611 USA.
   [Heard-Garris, Nia J.] Northwestern Univ, Ann & Robert H Lurie Childrens Hosp Chicago, Mary Ann & J Milburn Smith Child Hlth Res Outreac, Feinberg Sch Med,Stanley Marine Childrens Res Ins, Chicago, IL 60611 USA.
   [Johnson, Sara B.] Johns Hopkins Sch Med, Dept Pediat, Div Gen Pediat, Baltimore, MD USA.
   [Slopen, Natalie] Harvard TH Chan Sch Publ Hlth, Dept Social & Behav Sci, Boston, MA USA.
   [Watamura, Sarah E.] Univ Denver, Dept Psychol, Denver, CO 80208 USA.
C3 Emory University; State University of New York (SUNY) System; University
   at Albany, SUNY; University of Washington; University of Washington
   Seattle; National Institutes of Health (NIH) - USA; NIH National Heart
   Lung & Blood Institute (NHLBI); Wingate University; Baylor College of
   Medicine; Rice University; University of Texas System; UTMD Anderson
   Cancer Center; Ann & Robert H. Lurie Children's Hospital of Chicago; Ann
   & Robert H. Lurie Children's Hospital of Chicago; Northwestern
   University; Feinberg School of Medicine; Johns Hopkins University; Johns
   Hopkins Medicine; Harvard University; Harvard T.H. Chan School of Public
   Health; University of Denver
RP Suglia, SF (corresponding author), Emory Univ, Dept Epidemiol, Atlanta, GA 30322 USA.; Suglia, SF (corresponding author), Emory Univ, Rollins Sch Publ Hlth, Dept Epidemiol, Atlanta, GA 30322 USA.
EM shakira.suglia@emory.edu
RI Stoney, Catherine/AAD-7400-2020; , Sara Johnson/KZU-5191-2024
OI JOHNSON, SARA/0000-0003-4532-1847; Watamura, Sarah/0000-0001-7860-0290
FU [K01HL147995];  [R01HL130103];  [R01HL153136];  [R01HD091132]; 
   [1R01HL151848-01];  [R01MD011746];  [R01HL125761];  [R01AG058704]; 
   [R01MD013320]; National Institute on Minority Health and Health
   Disparities [R01MD011746] Funding Source: NIH RePORTER
FX This work was supported by grant, K01HL147995 (Heard-Garris) , Bleil
   (R01HL130103; R01HL153136; R01HD091132) , Slopen (1R01HL151848-01) ,
   Johnson (R01MD011746) , Suglia (R01HL125761;R01AG058704 ;R01MD013320) .
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NR 139
TC 23
Z9 25
U1 0
U2 11
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0091-7435
EI 1096-0260
J9 PREV MED
JI Prev. Med.
PD DEC
PY 2021
VL 153
AR 106736
DI 10.1016/j.ypmed.2021.106736
EA JUL 2021
PG 8
WC Public, Environmental & Occupational Health; Medicine, General &
   Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; General & Internal Medicine
GA WB4VT
UT WOS:000703571900008
PM 34293381
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Lilly, MM
   London, MJ
   Mercer, MC
AF Lilly, Michelle M.
   London, Melissa J.
   Mercer, Mary C.
TI Predictors of Obesity and Physical Health Complaints Among 911
   Telecommunicators
SO SAFETY AND HEALTH AT WORK
LA English
DT Article
DE obesity; peritraumatic distress; psychopathology; 911 telecommunicators
ID POSTTRAUMATIC-STRESS-DISORDER; EMOTION REGULATION; PSYCHOMETRIC
   PROPERTIES; METABOLIC SYNDROME; CRITICAL INCIDENTS; POLICE OFFICERS;
   MENTAL-HEALTH; ALCOHOL-USE; PTSD; PREVALENCE
AB Background: This study aims to: (1) examine rates of obesity and physical health complaints among 911 telecommunicators; and (2) document the role of emotion dysregulation, psychological inflexibility, duty-related distress and dissociation, and psychopathology in predicting obesity and physical health complaints in this population.
   Methods: The sample consisted of 911 telecommunicators from across the country (N = 758). Participants completed an online survey assessing their mental and physical health functioning.
   Results: A total of 82.5% of the sample reported a body mass index that fell within the overweight or obese category and an average of 17 physical health complaints within the past month. Peritraumatic reactions (distress and dissociation), emotion dysregulation, and psychological inflexibility had effects on physical health largely through psychopathology (alcohol abuse, post-traumatic stress disorder, and depression).
   Conclusion: Development of adapted prevention and intervention efforts with this population is needed. Copyright (C) 2015, Occupational Safety and Health Research Institute. Published by Elsevier.
C1 [Lilly, Michelle M.; London, Melissa J.; Mercer, Mary C.] Northern Illinois Univ, Dept Psychol, Psychology Comp Sci Bldg, De Kalb, IL 60115 USA.
C3 Northern Illinois University
RP Lilly, MM (corresponding author), Northern Illinois Univ, Dept Psychol, Psychology Comp Sci Bldg, De Kalb, IL 60115 USA.
EM mlilly1@niu.edu
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NR 67
TC 15
Z9 19
U1 0
U2 3
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2093-7911
EI 2093-7997
J9 SAF HEALTH WORK-KR
JI Saf. Health Work
PD MAR
PY 2016
VL 7
IS 1
BP 55
EP 62
DI 10.1016/j.shaw.2015.09.003
PG 8
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA ER8TK
UT WOS:000399096000009
PM 27014492
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Gawlik-Kotelnicka, O
   Czarnecka-Chrebelska, K
   Margulska, A
   Pikus, E
   Wasiak, J
   Skowronska, A
   Brzezianska-Lasota, E
   Strzelecki, D
AF Gawlik-Kotelnicka, Oliwia
   Czarnecka-Chrebelska, Karolina
   Margulska, Aleksandra
   Pikus, Ewa
   Wasiak, Jakub
   Skowronska, Anna
   Brzezianska-Lasota, Ewa
   Strzelecki, Dominik
TI Associations between intestinal fatty-acid binding protein and clinical
   and metabolic characteristics of depression
SO PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
LA English
DT Article
DE Depressive disorders; Abdominal obesity; Intestinal fatty acid-binding
   protein; Leaky gut syndrome; Intestinal permeability; Antidepressants;
   Anxiety
ID I-FABP; GUT MICROBIOTA; ANTIDEPRESSANTS; DYSBIOSIS; STATEMENT; DISEASE;
   DAMAGE; RISK
AB Introduction: The topic of increased intestinal permeability is associated with disruption of the intestinal barrier, leading to the "leaky gut" syndrome. Depressive disorders often coexist with abdominal obesity, metabolic syndrome, or its components and complications. Intestinal permeability has been proven to relate to all of the above. Methods: In this cross-sectional study, we aimed to assess the "leaky gut" blood biomarker- intestinal fatty acid-binding protein (I-FABP)- in 114 adult patients diagnosed with depressive disorders depending on abdominal obesity comorbidity, depression, anxiety, and stress level, or antidepressant use. The corrected pvalue was set at 0.02. We analyzed patients' mental state, diet, anthropometric parameters, metabolic laboratory markers and I-FABP. Results: There was no difference in circulating I-FABP levels between obese and non-obese patients with depressive disorders (p p = 0.648). Similarly, I-FABP levels were not different in patients with different emotional symptoms severity (p p = 0.829 for self-assessed depression, p = 0.164 for anxiety, and p = 0.543 for stress). But, I-FABP levels differed significantly between patients treated and not treated with antidepressants (p p = 0.011). In general linear model analysis treatment with antidepressants, anxiety severity level, their interaction, along with smoking status, drinks intake, and using dietary supplements were shown to significantly explain I-FABP variance (p p <0.001, R 2 adj = 0.261). Conclusions: Comorbid obesity did not increase intestinal permeability circulating marker, I-FABP, in the population of patients with depressive disorders. Treatment with antidepressants may be connected to higher I-FABP levels. Using dietary supplements, drinks intake, smoking status, or anxiety level may serve as explanatory factors.
C1 [Gawlik-Kotelnicka, Oliwia; Skowronska, Anna; Strzelecki, Dominik] Med Univ Lodz, Dept Affect & Psychot Disorders, Czechoslowacka 8-10, PL-92216 Lodz, Poland.
   [Czarnecka-Chrebelska, Karolina; Pikus, Ewa; Brzezianska-Lasota, Ewa] Med Univ Lodz, Dept Biomed & Genet, PL-92213 Lodz, Poland.
   [Margulska, Aleksandra] Med Univ Lodz, Dept Child & Adolescent Psychiat, Czechoslowacka 8-10, PL-92216 Lodz, Poland.
   [Wasiak, Jakub] Med Univ Lodz, Fac Med, Kosciuszki 4, PL-90419 Lodz, Poland.
C3 Medical University Lodz; Medical University Lodz; Medical University
   Lodz; Medical University Lodz
RP Gawlik-Kotelnicka, O (corresponding author), Med Univ Lodz, Dept Affect & Psychot Disorders, Czechoslowacka 8-10, PL-92216 Lodz, Poland.
EM oliwia.gawlik@umed.lodz.pl; karolina.czarnecka@umed.lodz.pl;
   aleksandra.margulska@umed.lodz.pl; ewa.pikus@umed.lodz.pl;
   jakub.wasiak@stud.umed.lodz.pl; ewa.pikus@umed.lodz.pl;
   dominik.strzelecki@umed.lodz.pl
RI Strzelecki, Dominik/S-9340-2016; Gawlik-Kotelnicka,
   Oliwia/ITU-7979-2023; Gawlik-Kotelnicka, Oliwia/S-9936-2016;
   Czarnecka-Chrebelska, Karolina/C-8609-2011
OI Strzelecki, Dominik/0000-0002-8559-1078; Wasiak,
   Jakub/0000-0002-5973-6077; Gawlik-Kotelnicka,
   Oliwia/0000-0003-1398-3117; Brzezianska-Lasota, Ewa/0000-0002-0882-1458;
   Margulska, Aleksandra/0000-0003-1229-0925; Czarnecka-Chrebelska,
   Karolina/0000-0003-4013-513X
FU Medical University of Lodz [503/1-155-02/503-11-003-20,
   502-03/1-155-02/502-14-386-18]
FX This research was funded by the Medical University of Lodz, grant number
   503/1-155-02/503-11-003-20 and 502-03/1-155-02/502-14-386-18.
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NR 86
TC 2
Z9 2
U1 2
U2 9
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0278-5846
EI 1878-4216
J9 PROG NEURO-PSYCHOPH
JI Prog. Neuro-Psychopharmacol. Biol. Psychiatry
PD JAN 10
PY 2025
VL 136
AR 111170
DI 10.1016/j.pnpbp.2024.111170
EA OCT 2024
PG 11
WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA J8A0K
UT WOS:001339219600001
PM 39393435
DA 2025-06-11
ER

PT J
AU Franz, HM
   Corbo, V
   Fonda, JR
   Levin, LK
   Milberg, WP
   McGlinchey, RE
AF Franz, Hannah M.
   Corbo, Vincent
   Fonda, Jennifer R.
   Levin, Laura K.
   Milberg, William P.
   McGlinchey, Regina E.
TI The Impact of Interpersonal Early Life Trauma on Cardio-Metabolic Health
   in Post-9/11 Veterans
SO HEALTH PSYCHOLOGY
LA English
DT Article
DE PTSD; MetS; veterans; childhood trauma; triglycerides
ID POSTTRAUMATIC-STRESS-DISORDER; CHILDHOOD TRAUMA; CARDIOVASCULAR-DISEASE;
   HEART-DISEASE; SEXUAL-ABUSE; RISK-FACTOR; MALTREATMENT; DEPRESSION;
   NEUROBIOLOGY; PSYCHOPATHOLOGY
AB Objective: This study examined the impact of early life trauma (ELT) on cardio-metabolic health in veterans from post-9/11 conflicts who experience significant stress from deployment and reintegration. Method: Three hundred thirty-seven veterans from the Translational Research Center for Traumatic Brain Injury and Stress Disorders study underwent physiological assessments, including blood pressure and waist circumference. Fasting blood samples were collected to measure metabolic syndrome (MetS; cholesterol/triglycerides/glucose). ELT history was determined using the Traumatic Life Events Questionnaire. Posttraumatic stress disorder (PTSD) symptoms were assessed using the Clinician-Administered PTSD Scale. Logistic regression models examined the association of ELT and MetS diagnostic criteria while controlling for confounders. Results: The adjusted logistic regression showed a significant relationship between interpersonal ELT (IP ELT) and risk of MetS, with IP ELT having an approximately 3-fold increase in the risk of cardio-metabolic syndrome compared with those with no trauma (odds ratio [OR] = 3.06, p < .05). IP ELT was associated with over a 2-fold increased risk of elevated triglycerides compared with those with no trauma (OR = 2.06, p < .05). PTSD symptoms also explained in part the IP-ELT/MetS relationship. Veterans with any ELT were significantly more likely to meet for a current diagnosis of PTSD. Conclusions: Our findings suggest that veterans with IP ELT are more likely to meet MetS and PTSD diagnostic criteria than veterans without IP ELT. This is concerning considering the young age of the sample and stresses the importance of an integrated and holistic approach in the assessment of physical and mental health in returning veterans.
C1 [Franz, Hannah M.; Corbo, Vincent; Fonda, Jennifer R.; Levin, Laura K.; Milberg, William P.; McGlinchey, Regina E.] VA Boston Healthcare Syst, Translat Res Ctr TBI & Stress Disorders TRACTS, 11D-132,150 South Huntington Ave,Jamaica Plain, Boston, MA 02130 USA.
   [Corbo, Vincent] Southern New Hampshire Univ, Dept Psychol, Manchester, NH USA.
   [Fonda, Jennifer R.; Milberg, William P.] VA Boston Healthcare Syst, GRECC, Boston, MA USA.
   [Fonda, Jennifer R.; McGlinchey, Regina E.] Harvard Med Sch, Dept Psychiat, Boston, MA USA.
C3 Harvard University; Harvard University Medical Affiliates; US Department
   of Veterans Affairs; Veterans Health Administration (VHA); VA Boston
   Healthcare System; Harvard University; Harvard University Medical
   Affiliates; US Department of Veterans Affairs; Veterans Health
   Administration (VHA); VA Boston Healthcare System; Geriatric Research
   Education & Clinical Center; Harvard University; Harvard Medical School
RP McGlinchey, RE (corresponding author), VA Boston Healthcare Syst, Translat Res Ctr TBI & Stress Disorders TRACTS, 11D-132,150 South Huntington Ave,Jamaica Plain, Boston, MA 02130 USA.
EM Regina_McGlinchey@hms.harvard.edu
RI Fonda, Jennifer/ABG-2890-2021
OI Fonda, Jennifer/0000-0001-9482-2918; McGlinchey,
   Regina/0000-0003-4809-1194
FU U.S. Department of Veterans Affairs through the Translational Research
   Center for TBI and Stress Disorders (TRACTS), a VA Rehabilitation
   Research and Development Traumatic Brain Injury National Research Center
   [B9254-C]
FX This research was supported by the U.S. Department of Veterans Affairs
   through the Translational Research Center for TBI and Stress Disorders
   (TRACTS), a VA Rehabilitation Research and Development Traumatic Brain
   Injury National Research Center (B9254-C). All procedures were approved
   by the VA Boston Healthcare System Institutional Review Board and
   Research and Development Committee.
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NR 55
TC 5
Z9 6
U1 0
U2 9
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 0278-6133
EI 1930-7810
J9 HEALTH PSYCHOL
JI Health Psychol.
PD FEB
PY 2019
VL 38
IS 2
BP 113
EP 121
DI 10.1037/hea0000706
PG 9
WC Psychology, Clinical; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology
GA HH8KW
UT WOS:000455981900002
PM 30652910
OA Green Accepted, hybrid
DA 2025-06-11
ER

PT J
AU Devesa, A
   Fuster, V
   García-Lunar, I
   Oliva, B
   García-Alvarez, A
   Moreno-Arciniegas, A
   Vazirani, R
   Pérez-Herreras, C
   Marina, P
   Bueno, H
   Fernández-Friera, L
   Fernández-Ortiz, A
   Sanchez-Gonzalez, J
   Ibanez, B
AF Devesa, Ana
   Fuster, Valentin
   Garcia-Lunar, Ines
   Oliva, Belen
   Garcia-Alvarez, Ana
   Moreno-Arciniegas, Andrea
   Vazirani, Ravi
   Perez-Herreras, Cristina
   Marina, Pablo
   Bueno, Hector
   Fernandez-Friera, Leticia
   Fernandez-Ortiz, Antonio
   Sanchez-Gonzalez, Javier
   Ibanez, Borja
TI Coronary Microvascular Function in Asymptomatic Middle-Aged Individuals
   With Cardiometabolic Risk Factors
SO JACC-CARDIOVASCULAR IMAGING
LA English
DT Article
DE cardiovascular risk factors; coronary microvascular function;
   quantitative cardiac magnetic resonance myocardial perfusion;
   subclinical atherosclerosis
ID QUANTITATIVE MYOCARDIAL-PERFUSION; SUBCLINICAL ATHEROSCLEROSIS PESA;
   CARDIAC MAGNETIC-RESONANCE; ARTERY-DISEASE; FLOW RESERVE; PROGNOSTIC
   VALUE; DYSFUNCTION; PROGRESSION; EVENTS; ADULTS
AB BACKGROUND In patients with ischemic heart disease, coronary microvascular dysfunction is associated with cardiovascular risk factors and poor prognosis; however, data from healthy individuals are scarce. OBJECTIVES The purpose of this study was to assess the impact of cardiovascular risk factors and subclinical atherosclerosis on coronary microvascular function in middle-aged asymptomatic individuals. METHODS Myocardial perfusion was measured at rest and under stress using cardiac magnetic resonance in 453 individuals and used to generate myocardial blood flow (MBF) maps and calculate myocardial perfusion reserve (MPR). Subclinical atherosclerosis was assessed using 3-dimensional vascular ultrasound of the carotid and femoral arteries and coronary artery calcium scoring at baseline and at 3-year follow-up. RESULTS Median participant age was 52.6 years (range: 48.9-55.8 years), and 84.5% were male. After adjusting for age and sex, rest MBF was directly associated with the number of the metabolic syndrome components present (elevated waist circumference, systolic and diastolic blood pressure, fasting glucose, and triglycerides and low high-density lipoprotein cholesterol), insulin resistance (homeostatic model assessment for insulin resistance), and presence of diabetes. MPR was reduced in the presence of several metabolic syndrome components, elevated homeostatic model assessment for insulin resistance, and diabetes. Stress MBF was inversely associated with coronary artery calcium presence and with global plaque burden. Higher stress MBF and MPR were associated with less atherosclerosis progression (increase in plaque volume) at 3 years. CONCLUSIONS In asymptomatic middle-aged individuals free of known cardiovascular disease, the presence of cardiometabolic risk factors and systemic (poly-vascular) subclinical atherosclerosis are associated with impaired coronary microvascular function. Better coronary microvascular function reduces atherosclerosis progression at follow-up. (Progression of Early Subclinical Atherosclerosis [PESA]; NCT01410318) (JACC Cardiovasc Imaging. 2025;18:48-58) (c) 2025 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
C1 [Devesa, Ana; Fuster, Valentin; Garcia-Lunar, Ines; Oliva, Belen; Garcia-Alvarez, Ana; Moreno-Arciniegas, Andrea; Vazirani, Ravi; Bueno, Hector; Fernandez-Friera, Leticia; Fernandez-Ortiz, Antonio; Ibanez, Borja] Ctr Nacl Invest Cardiovasc CNIC, Madrid, Spain.
   [Devesa, Ana; Fuster, Valentin] Icahn Sch Med Mt Sinai, Mt Sinai Heart, New York, NY USA.
   [Devesa, Ana] Icahn Sch Med Mt Sinai, Biomed Engn & Imaging Inst, New York, NY USA.
   [Garcia-Lunar, Ines] Univ Hosp La Moraleja, Madrid, Spain.
   [Garcia-Lunar, Ines; Fernandez-Ortiz, Antonio; Ibanez, Borja] CIBER Enfermedades Cardiovasc CIBERCV, Madrid, Spain.
   [Garcia-Alvarez, Ana] Hosp Clin IDIBAPS, Infect Dis Dept, Barcelona, Spain.
   [Vazirani, Ravi; Fernandez-Ortiz, Antonio] Univ Complutense Madrid, Hosp Clin San Carlos, IdISSC, Madrid, Spain.
   [Perez-Herreras, Cristina; Marina, Pablo] Banco Santander, Madrid, Spain.
   [Bueno, Hector] Univ Hosp 12 Octubre, Cardiol Dept, Madrid, Spain.
   [Bueno, Hector] i 12 Res Inst, Madrid, Spain.
   [Fernandez-Friera, Leticia] Hosp Univ HM Monteprincipe CIEC, Madrid, Spain.
   [Sanchez-Gonzalez, Javier] Philips Healthcare, Madrid, Spain.
   [Ibanez, Borja] IIS Fdn Jimenez Diaz Univ Hosp, Cardiol Dept, Madrid, Spain.
C3 Centro Nacional de Investigaciones Cardiovasculares (CNIC); Icahn School
   of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai;
   CIBER - Centro de Investigacion Biomedica en Red; CIBERCV; University of
   Barcelona; Hospital Clinic de Barcelona; IDIBAPS; Complutense University
   of Madrid; Hospital Clinico San Carlos; Santander; Hospital
   Universitario 12 de Octubre; Philips; Philips Healthcare; Fundacion
   Jimenez Diaz
RP Ibanez, B (corresponding author), Ctr Nacl Invest Cardiovasc CNIC, Myocardial Homeostasis & Cardiac Injury Program, C-Melchor Fernandez Almagro 3, Madrid 28029, Spain.; Fuster, V (corresponding author), CNIC, C-Melchor Fernandez Almagro 3, Madrid 28029, Spain.
EM vfuster@cnic.es; bibanez@cnic.es
RI Garcia-Lunar, Ines/G-6852-2017; Friera, Leticia/E-9931-2015; Vazirani
   Ballesteros, Ravi/MBV-9266-2025; Fernández Ortiz, Antonio/JJE-4178-2023;
   Ibáñez, Borja/J-6993-2014; BUENO, HECTOR/I-3910-2015
OI Vazirani Ballesteros, Ravi/0000-0002-7337-0593; Devesa,
   Ana/0000-0001-5981-2546; BUENO, HECTOR/0000-0003-0277-7596
FU Centro Nacional de Investigaciones Cardiovasculares (CNIC); Santander
   Bank; European Commission; La Caixa Foundation (DIREQT2Heart) [HR
   22-00533]; Spanish Ministry of Science and Innovation
   [PID2019-110369RB-I00]; Red Madrilena de Nano-medicina en Imagen
   Molecular-Comunidad de Madrid [S2017/BMD-386 7 RENIM-CM]; La Caixa
   Foundation; Instituto de Salud Carlos III (ISCIII); Ministerio de
   Ciencia, Innovacion y Universidades (MICIU); Pro CNIC Foundation;
   MICIU/AEI;  [ERC-CoG 819775];  [H2020-HEALTH 945118]; 
   [CEX2020-001041-S]
FX The PESA study is funded by the Centro Nacional de Investigaciones
   Cardiovasculares (CNIC) and Santander Bank. Dr Ibanez is supported by
   the European Commission (grant numbers ERC-CoG 819775 and H2020-HEALTH
   945118), La Caixa Foundation (HR 22-00533, DIREQT2Heart), the Spanish
   Ministry of Science and Innovation (PID2019-110369RB-I00), and the Red
   Madrilena de Nano-medicina en Imagen Molecular-Comunidad de Madrid
   (S2017/BMD-386 7 RENIM-CM). Dr Devesa is an Alfonso Martin Escudero
   fellow and is scientifically supported by La Caixa Foundation. The CNIC
   is supported by the Instituto de Salud Carlos III (ISCIII), the
   Ministerio de Ciencia, Innovacion y Universidades (MICIU) and the Pro
   CNIC Foundation, and is a Severo Ochoa Center of Excellence (grant
   CEX2020-001041-S funded by MICIU/AEI/10.13039/501100011033) . Dr
   Sanchez-Gonzalez is a Philips employee. All other authors have reported
   that they have no relationships relevant to the contents of this paper
   to disclose.
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NR 49
TC 3
Z9 3
U1 9
U2 12
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1936-878X
EI 1876-7591
J9 JACC-CARDIOVASC IMAG
JI JACC-Cardiovasc. Imag.
PD JAN
PY 2025
VL 18
IS 1
BP 48
EP 58
DI 10.1016/j.jcmg.2024.08.002
EA JAN 2025
PG 11
WC Cardiac & Cardiovascular Systems; Radiology, Nuclear Medicine & Medical
   Imaging
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Radiology, Nuclear Medicine &
   Medical Imaging
GA S6U2N
UT WOS:001399541100001
PM 39269413
OA hybrid
DA 2025-06-11
ER

PT J
AU Basaran, PÖ
AF Basaran, Pinar Ozge
TI Assessment of Autonomic Dysfunction with the COMPASS-31 Test and Its
   Relationship with Disease Activity, Cardiovascular Risk, Anxiety, and
   Depression in Patients with Sjogren's Syndrome
SO CYPRUS JOURNAL OF MEDICAL SCIENCES
LA English
DT Article
DE Autonomic dysfunction; Sjogren's syndrome; COMPASS -31; cardiovascular
   risk; depression and anxiety
ID HEART-RATE-VARIABILITY; METABOLIC SYNDROME
AB BACKGROUND/AIMS: Primary Sjogren's syndrome (pSS) is a chronic, auto-immune, multisystemic inflammatory disease and this chronic inflammation may cause risk factors for autonomic dysfunction (AD) and/or cardiovascular risk. This study aimed to determine the frequency of AD in pSS patients using Composite Autonomic Symptom Score-31 (COMPASS-31) and also the relationship between disease activity and cardiovascular risks and AD, as well as to compare the symptoms of AD with healthy study participants. MATERIALS AND METHODS: This was a cross-sectional study. The research cohort was comprised of 42 patients diagnosed with pSS and 42 healthy controls. AD was evaluated with the COMPASS-31 questionnaire. Cardiovascular risk was assessed with the 10-year Framingham Risk Score (FRS) algorithm. Body mass index, dyslipidemia, and metabolic syndrome (MetS) were recorded. In the pSS group, disease activity was evaluated with European League against Rheumatism Sjogren's Syndrome Disease Activity Index (ESSDAI) and European League against Rheumatism Sjogren's Syndrome Patient Reported Index (ESSPRI). Additionally, the Numerical Rating Scale and Hospital Anxiety and Depression RESULTS: Patients with pSS had a significantly higher mean total COMPASS-31 score than the controls (58.5 vs. 50.0; p=0.040). In sub-domain analysis, pSS patients exhibited significantly higher mean scores in the pupillomotor domain than controls (13.5 vs. 9.0; p=0.002). MetS (10 vs. 2; p=0.023), the mean 10-year FRS (6.0 vs. 2.0; p=0.012), HADS depression score (9.5 vs. 5.0; p=0.001) and HADS anxiety score were higher in those patients with pSS (11.3 vs. 6.7; p<0.001). COMPASS-31 was not correlated with ESSDAI or ESSPRI (p=0.128, p=0.0.66 respectively). The FRS and HADS depression score were evaluated as being effective on the COMPASS-31 score (p=0.535, p=0.465 respectively). CONCLUSION: An increased prevalence of AD, cardiovascular risk, MetS, depression, and anxiety levels in patients with pSS was found in this study. The total COMPASS score did not correlate with disease activity. The COMPASS-31 questionnaire showed a relationship between cardiovascular risk and HAD depression symptom levels.
C1 [Basaran, Pinar Ozge] Hitit Univ Corum Erol Olcok Training & Res Hosp, Dept Phys Med & Rehabil, Corum, Turkiye.
RP Basaran, PÖ (corresponding author), Hitit Univ Corum Erol Olcok Training & Res Hosp, Dept Phys Med & Rehabil, Corum, Turkiye.
EM pinarozge@yahoo.com
RI Başaran, Pınar/IZQ-0666-2023
FX Financial Disclosure: The author declared that this study had received
   no financial support.
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NR 31
TC 0
Z9 0
U1 2
U2 2
PU GALENOS PUBL HOUSE
PI ISTANBUL
PA Kacamak Sokak 21/1, ISTANBUL, Findikzade, TURKIYE
SN 2149-7893
EI 2536-507X
J9 CYPRUS J MED SCI
JI Cyprus J. Med. Sci.
PD JUN
PY 2024
VL 9
IS 3
BP 212
EP 218
DI 10.4274/cjms.2024.2023-126
PG 7
WC Medicine, Research & Experimental
WE Emerging Sources Citation Index (ESCI)
SC Research & Experimental Medicine
GA ZG2G4
UT WOS:001274070500010
OA gold
DA 2025-06-11
ER

PT J
AU Masenga, SK
   Kabwe, LS
   Chakulya, M
   Kirabo, A
AF Masenga, Sepiso K.
   Kabwe, Lombe S.
   Chakulya, Martin
   Kirabo, Annet
TI Mechanisms of Oxidative Stress in Metabolic Syndrome
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE oxidative stress; inflammatory cytokines; metabolic syndrome; obesity;
   hypertension; insulin resistance; hyperglycemia; hyperlipidemia;
   cardiovascular disease
ID ENDOPLASMIC-RETICULUM STRESS; LOW-GRADE INFLAMMATION; NITRIC-OXIDE
   SYNTHASE; NF-KAPPA-B; INSULIN-RESISTANCE; GUT MICROBIOTA;
   SERINE/THREONINE PHOSPHORYLATION; MEDITERRANEAN DIET; DIABETES-MELLITUS;
   OBESITY
AB Metabolic syndrome is a cluster of conditions associated with the risk of diabetes mellitus type 2 and cardiovascular diseases (CVDs). Metabolic syndrome is closely related to obesity. Increased adiposity promotes inflammation and oxidative stress, which are precursors of various complications involving metabolic syndrome components, namely insulin resistance, hypertension, and hyperlipidemia. An increasing number of studies confirm the importance of oxidative stress and chronic inflammation in the etiology of metabolic syndrome. However, few studies have reviewed the mechanisms underlying the role of oxidative stress in contributing to metabolic syndrome. In this review, we highlight mechanisms by which reactive oxygen species (ROS) increase mitochondrial dysfunction, protein damage, lipid peroxidation, and impair antioxidant function in metabolic syndrome. Biomarkers of oxidative stress can be used in disease diagnosis and evaluation of severity.
C1 [Masenga, Sepiso K.; Kabwe, Lombe S.; Chakulya, Martin] Mulungushi Univ, Sch Med & Hlth Sci, HAND Res Grp, Livingstone Campus,POB 60009, Livingstone 60009, Zambia.
   [Masenga, Sepiso K.; Kirabo, Annet] Vanderbilt Univ, Med Ctr, Dept Med, Room 536,Robinson Res Bldg, Nashville, TN 37232 USA.
C3 Vanderbilt University
RP Masenga, SK (corresponding author), Mulungushi Univ, Sch Med & Hlth Sci, HAND Res Grp, Livingstone Campus,POB 60009, Livingstone 60009, Zambia.; Masenga, SK; Kirabo, A (corresponding author), Vanderbilt Univ, Med Ctr, Dept Med, Room 536,Robinson Res Bldg, Nashville, TN 37232 USA.
EM sepisomasenga@gmail.com; annet.kirabo@vumc.org
RI Kirabo, Annet/AGN-6915-2022; Masenga, Sepiso/O-7669-2018
OI Kirabo, Annet/0000-0001-8580-9359; Masenga, Sepiso/0000-0003-4376-5831
FU Fogarty International Center of the National Institutes of Health
   [R03HL155041, R01HL147818, R01HL144941, 2D43TW009744]
FX This work was supported by the Fogarty International Center of the
   National Institutes of Health grants R03HL155041, R01HL147818, and
   R01HL144941 (AK), and 2D43TW009744 (SKM). The content is solely the
   responsibility of the authors and does not represent the official views
   of the National Institutes of Health.
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NR 236
TC 240
Z9 245
U1 94
U2 222
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD APR 26
PY 2023
VL 24
IS 9
AR 7898
DI 10.3390/ijms24097898
PG 28
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA G1SN9
UT WOS:000987040300001
PM 37175603
OA gold, Green Published
HC Y
HP Y
DA 2025-06-11
ER

PT J
AU Reims, HM
   Sevre, K
   Fossum, E
   Mellem, H
   Eide, IK
   Kjeldsen, SE
AF Reims, HM
   Sevre, K
   Fossum, E
   Mellem, H
   Eide, IK
   Kjeldsen, SE
TI Adrenaline during mental stress in relation to fitness, metabolic risk
   factors and cardiovascular responses in young men
SO BLOOD PRESSURE
LA English
DT Article
DE adrenaline; blood pressure; heart rate; metabolic syndrome X; physical
   fitness; psychological stress
ID SYMPATHETIC-NERVOUS-SYSTEM; BLOOD-PRESSURE RESPONSES;
   ESSENTIAL-HYPERTENSION; PLASMA-CATECHOLAMINES; AEROBIC FITNESS; INSULIN
   SENSITIVITY; HEART-RATE; BODY-FAT; EPINEPHRINE; REACTIVITY
AB We studied plasma adrenaline ( A) in relation to physical fitness, metabolic cardiovascular risk factors and cardiovascular responses. Men ( age 21-24 years) with high and normal ( both n=519) screening blood pressure ( BP) were studied cross-sectionally. We measured peak oxygen uptake ( VO2peak) ( treadmill exercise), and plasma catecholamines, heart rate ( HR), finger systolic ( SBP) and diastolic ( DBP) BP, and insulin-adjusted glucose disposal rate ( GDR/I) during a hyperinsulinaemic glucose clamp ( rest) and mental arithmetic stress test ( MST). By multiple regression, A at rest ( A(rest)) ( beta 50.37, p < 0.05) and during MST ( A(mst)) ( beta 50.40, p < 0.01) were associated with high screening BP. In the respective models, Arest was negatively related to body mass index ( BMI) ( beta 520.56, p < 0.001) and A(mst) positively to VO2peak ( beta 50.54, p < 0.001). BP and HR responses correlated positively with VO2peak, but were determined by A(mst) in multiple regression models. Independently of BMI and VO2peak, serum high-density lipoprotein cholesterol was positively related to A levels, whereas GDR/I was independently related only to VO2peak. Increased adrenaline secretion may be related to high BP, but may at the same time be associated with a beneficial metabolic profile.
C1 Ullevaal Univ Hosp, Dept Cardiol, Oslo, Norway.
   Ullevaal Univ Hosp, Dept Pulm Med, Oslo, Norway.
   Ullevaal Univ Hosp, Dept Nephrol, Oslo, Norway.
   Univ Michigan, Dept Cardiovasc Med, Ann Arbor, MI 48109 USA.
C3 University of Oslo; University of Oslo; University of Oslo; University
   of Michigan System; University of Michigan
RP Ullevaal Univ Hosp, Dept Pathol, Kirkeveien 166, NO-0407 Oslo, Norway.
EM h.m.reims@medisin.uio.no
RI Kjeldsen, Sverre/S-1774-2018
OI Reims, Henrik/0000-0002-2018-7787
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NR 57
TC 12
Z9 19
U1 0
U2 8
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
EI 1651-1999
J9 BLOOD PRESSURE
JI Blood Pressure
PD SEP 1
PY 2005
VL 14
IS 4
BP 217
EP 226
DI 10.1080/08037050510034275
PG 10
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 960WF
UT WOS:000231623200004
PM 16126555
OA Bronze
DA 2025-06-11
ER

PT J
AU Moraitis, AG
   Block, T
   Nguyen, D
   Belanoff, JK
AF Moraitis, Andreas G.
   Block, Thaddeus
   Dat Nguyen
   Belanoff, Joseph K.
TI The role of glucocorticoid receptors in metabolic syndrome and
   psychiatric illness
SO JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
LA English
DT Review
DE Glucocorticoid receptor; Polymorphism; Metabolic syndrome; Psychiatric
   disorders
ID HPA-AXIS; FUNCTIONAL POLYMORPHISM; PSYCHOTIC DEPRESSION; MAJOR
   DEPRESSION; BODY-COMPOSITION; IN-VIVO; C-JUN; GENE; RISK; ASSOCIATION
AB Glucocorticoids (GCs) are involved in a large number of the physiological changes associated with metabolic syndrome and certain psychiatric illness. Although significance is often given to the concentration of GC, its biological action is determined by the activation of intracellular GC receptors (GR). Genetic polymorphisms of the GR and the large array of GR related cofactors can directly or indirectly affect the pathophysiology and evolution of these conditions. This review will discuss the effects of GR mutations on metabolic syndrome and psychotic depression. (C) 2016 The Authors. Published by Elsevier Ltd.
C1 [Moraitis, Andreas G.; Block, Thaddeus; Dat Nguyen; Belanoff, Joseph K.] Corcept Therapeut, 149 Commonwealth, Menlo Pk, CA 94025 USA.
   [Block, Thaddeus; Belanoff, Joseph K.] Stanford Univ, Sch Med, Dept Psychiat & Behav Sci, Stanford, CA 94305 USA.
C3 Stanford University
RP Moraitis, AG; Belanoff, JK (corresponding author), Corcept Therapeut, 149 Commonwealth, Menlo Pk, CA 94025 USA.; Belanoff, JK (corresponding author), Stanford Univ, Sch Med, Dept Psychiat & Behav Sci, Stanford, CA 94305 USA.
EM Amoraitis@corcept.com
RI MORAITIS, ANDREAS/S-4220-2019
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NR 71
TC 54
Z9 58
U1 0
U2 16
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0960-0760
J9 J STEROID BIOCHEM
JI J. Steroid Biochem. Mol. Biol.
PD JAN
PY 2017
VL 165
SI SI
BP 114
EP 120
DI 10.1016/j.jsbmb.2016.03.023
PN A
PG 7
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA EF7JP
UT WOS:000390506200015
PM 27002803
OA hybrid
DA 2025-06-11
ER

PT J
AU Hooper, SC
   Espinoza, SE
   Marshall, VB
   Kilpela, LS
AF Hooper, Savannah C. C.
   Espinoza, Sara E. E.
   Marshall, Victoria B. B.
   Kilpela, Lisa S. S.
TI The Clinical Phenotype of Binge Eating Disorder among Postmenopausal
   Women: A Pilot Study
SO NUTRIENTS
LA English
DT Article
DE binge eating disorder; over nutrition; cardiometabolic health; physical
   functioning; body composition; post-menopausal
ID SLEEP QUALITY INDEX; OLDER-ADULTS; METABOLIC SYNDROME; CARDIOVASCULAR
   RISK; SARCOPENIC OBESITY; MUSCLE QUALITY; MENTAL-HEALTH; UNITED-STATES;
   OF-LIFE; COMMUNITY
AB Binge eating disorder (BED), a form of overnutrition, may impact healthy aging for postmenopausal women. In community samples, 12-26% of older women (ages 60+) engage in binge eating. In younger adults, BED is comorbid with physical and psychological morbidities. However, little is known regarding the clinical phenotype, including medical and psychiatric comorbidities, of BED in postmenopausal women. This pilot study sought to identify psychosomatic, cardiometabolic, body composition, and physical function characteristics of postmenopausal, older adult (age >= 60 years) women with BED. Participants (N = 21, ages 60-75) completed a battery of physical assessments and surveys assessing psychosomatic health. Overall, 62% of women reported BE onset during peri- or post-menopause. Rates of comorbid depression, anxiety, sleep problems, and a history of severe menopausal symptoms were high. Cardiometabolic health was poor, and 42.9% met the criteria for metabolic syndrome. Additionally, 71.4% met the BMI criteria for obesity, and 40% of this sample met the criteria for sarcopenic obesity. Almost half of the sample presented with at least one mobility limitation; 85.7% had poor endurance. Evidence suggests that BED is highly comorbid with other chronic health conditions and may complicate treatment of these conditions, warranting further investigation and increased attention from healthcare providers serving postmenopausal women.
C1 [Hooper, Savannah C. C.; Marshall, Victoria B. B.; Kilpela, Lisa S. S.] UT Hlth San Antonio, ReACH Ctr, San Antonio, TX 78229 USA.
   [Hooper, Savannah C. C.; Espinoza, Sara E. E.; Marshall, Victoria B. B.; Kilpela, Lisa S. S.] UT Hlth San Antonio, Barshop Inst Longev & Aging Studies, San Antonio, TX 78229 USA.
   [Espinoza, Sara E. E.; Kilpela, Lisa S. S.] UT Hlth San Antonio, Dept Med, Div Geriatr Gerontol & Palliat Med, San Antonio, TX 78229 USA.
   [Espinoza, Sara E. E.; Kilpela, Lisa S. S.] South Texas VA Healthcare Syst, Geriatr Res Educ & Clin Ctr, San Antonio, TX 78229 USA.
C3 University of Texas System; University of Texas Health Science Center at
   San Antonio; University of Texas System; University of Texas Health
   Science Center at San Antonio; University of Texas System; University of
   Texas Health Science Center at San Antonio; Geriatric Research Education
   & Clinical Center
RP Kilpela, LS (corresponding author), UT Hlth San Antonio, ReACH Ctr, San Antonio, TX 78229 USA.; Kilpela, LS (corresponding author), UT Hlth San Antonio, Barshop Inst Longev & Aging Studies, San Antonio, TX 78229 USA.; Kilpela, LS (corresponding author), UT Hlth San Antonio, Dept Med, Div Geriatr Gerontol & Palliat Med, San Antonio, TX 78229 USA.; Kilpela, LS (corresponding author), South Texas VA Healthcare Syst, Geriatr Res Educ & Clin Ctr, San Antonio, TX 78229 USA.
EM kilpela@uthscsa.edu
OI Marshall, Victoria Brooke/0000-0003-0431-9601; Espinoza,
   Sara/0000-0002-1116-302X
FU National Institute on Aging (NIA) [K76AG060003-A1]
FX This work was supported by the National Institute on Aging (NIA)
   [K76AG060003-A1].
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TC 4
Z9 4
U1 2
U2 5
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD APR 26
PY 2023
VL 15
IS 9
AR 2087
DI 10.3390/nu15092087
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA G2LP8
UT WOS:000987538700001
PM 37432212
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Damaiyanti, DW
   Tsai, ZY
   Masbuchin, AN
   Huang, CY
   Liu, PY
AF Damaiyanti, Dian W.
   Tsai, Zong-Yun
   Masbuchin, Ainun Nizar
   Huang, Ching-Ying
   Liu, Ping -Yen
TI Interplay between fish oil, obesity and cardiometabolic diabetes
SO JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
LA English
DT Review
DE Cardiometabolic; Diabetes; Fish oil; Inflammation; Obesity
ID ENDOTHELIAL DYSFUNCTION; CARDIOVASCULAR-DISEASE; ATRIAL-FIBRILLATION;
   FATTY-ACIDS; INSULIN; RISK; HEART; INFLAMMATION; GLUCOSE;
   OMEGA-3-FATTY-ACIDS
AB Diabetes, dyslipidemia, obesity, and cardiac dysfunction are the hallmarks of the dysfunction, and oxidative stress. Increased white fat, nonalcoholic fatty liver disease, diabetes, and cardiovascular disease are caused by obesity. Depression increases the risk of future obesity, a surprising link between obesity and neuropathology. High glucose levels, abnormal lipids, and metabolic syndrome are the root causes of CVD associated with diabetes. Diets high in fat induce insulin resistance and liver fat. Inflammation, diminished insulin signaling, and ectopic lipid accumulation are the causes of ectopic lipid accumulation. Polyunsaturated fatty acids with eicosapentaenoic acid and docohexasonoic acid inhibit the synthesis of triglycerides and increase their clearance. Omega-3 regulates the nervous system, blood pressure, hematic clotting, glucose tolerance, and inflammation. However, anxiety and depression can cause cardiovascular disease. It has been shown that PUFAs found in fish oil can improve glucose and lipid metabolism, cardiac membrane composition, and inflammation in the body. By repairing the dysregulation of metabolic syndrome, fish oil is a potential therapeutic target for cardio-vascular diseases. Copyright 2023, Formosan Medical Association. Published by Elsevier Taiwan LLC. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
C1 [Damaiyanti, Dian W.; Tsai, Zong-Yun; Masbuchin, Ainun Nizar; Huang, Ching-Ying; Liu, Ping -Yen] Natl Cheng Kung Univ, Coll Med, Inst Clin Med, Tainan 70457, Taiwan.
   [Damaiyanti, Dian W.] Univ Hang Tuah, Fac Dent, Dept Oral Biol, Surabaya 60111, Indonesia.
   [Masbuchin, Ainun Nizar] Univ Brawijaya, Fac Med, Dept Cardiol & Vasc Med, Malang 65145, Indonesia.
   [Liu, Ping -Yen] Natl Cheng Kung Univ, Natl Cheng Kung Univ Hosp, Coll Med, Div Cardiol,Internal Med, Tainan 70403, Taiwan.
C3 National Cheng Kung University; Brawijaya University; National Cheng
   Kung University; National Cheng Kung University Hospital
RP Liu, PY (corresponding author), Natl Cheng Kung Univ, Coll Med, Inst Clin Med, Tainan 70457, Taiwan.
EM damaiyanti@hangtuah.ac.id; larry@mail.ncku.edu.tw
RI Damaiyanti, Dian/ABC-4680-2021
OI Masbuchin, Ainun/0000-0002-3277-7848; Damaiyanti, Dian
   Widya/0000-0001-8894-074X; Liu, Ping-Yen/0000-0002-3643-5204
FU National Science and Technology Council, Taiwan
   [111-2314-B-006-017-MY3]; National Cheng Kung University Hospital,
   Tainan, Taiwan
FX Grant funding sources: This review was supported by grants from number
   of 111-2314-B-006-017-MY3 from National Science and Technology Council,
   Taiwan and a grant aid from National Cheng Kung University Hospital,
   Tainan, Taiwan.
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PU ELSEVIER TAIWAN
PI TAIPEI
PA RM N-412, 4F, CHIA HSIN BUILDING 11, NO 96, ZHONG SHAN N ROAD SEC 2,
   TAIPEI, 10449, TAIWAN
SN 0929-6646
EI 1876-0821
J9 J FORMOS MED ASSOC
JI J. Formos. Med. Assoc.
PD JUL
PY 2023
VL 122
IS 7
BP 528
EP 539
DI 10.1016/j.jfma.2023.03.013
EA JUN 2023
PG 12
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA J7SY2
UT WOS:001011595300001
PM 37002172
OA gold
DA 2025-06-11
ER

PT J
AU Chang, TT
   Lung, FW
   Yen, YC
AF Chang, Ting-Ting
   Lung, For-Wey
   Yen, Yung-Chieh
TI Depressive symptoms, cognitive impairment, and metabolic syndrome in
   community-dwelling elderly in Southern Taiwan
SO PSYCHOGERIATRICS
LA English
DT Article
DE cognitive impairment; depression; metabolic syndrome
ID ALZHEIMERS-DISEASE; DIABETES-MELLITUS; RISK-FACTOR; LATE-LIFE; DECLINE;
   DEMENTIA; POPULATION; INFLAMMATION; ASSOCIATION; EVOLUTION
AB ObjectiveMetabolic syndrome and depression are both thought to be associated with cognitive impairment in the elderly. Metabolic syndrome is also correlated with depression. We examined their possible pathways in a population-based sample.
   MethodsWe recruited 300 older community participants from Southern Taiwan. Demographics, medical history, severity of depressive symptoms, cognitive function, apolipoprotein genotyping, and lipid profile were collected. The presence of metabolic syndrome was confirmed with the Third Report of the National Cholesterol Education Program's Adult Treatment Panel. Possible relationships between metabolic syndrome, depressive symptoms, and cognitive dysfunction were explored using logistic regression and structured equation modelling.
   ResultsWhen gender, age, education, marital status, and apolipoprotein genotype were adjusted for logistic regression, metabolic syndrome and depressive symptoms were independent and significant predictors of cognitive dysfunction for community-dwelling elderly. In structural equation modelling, metabolic syndrome and depressive symptoms were correlated to each other, and both contributed to the presence of cognitive dysfunction.
   ConclusionsDepressive symptoms and metabolic syndrome are independently associated with cognitive impairment among community-dwelling elderly.
C1 [Chang, Ting-Ting; Yen, Yung-Chieh] E Da Hosp, Dept Psychiat, Taipei, Taiwan.
   [Lung, For-Wey] Taipei City Hosp, Songde Branch, Taipei, Taiwan.
   [Lung, For-Wey] Natl Def Med Ctr, Dept Psychiat, Taipei, Taiwan.
   [Lung, For-Wey] Kaohsiung Medial Univ, Dept Neurol, Kaohsiung, Taiwan.
   [Yen, Yung-Chieh] I Shou Univ, Sch Med, Kaohsiung, Taiwan.
C3 E-Da Hospital; Taipei City Hospital; National Defense Medical Center; I
   Shou University
RP Yen, YC (corresponding author), E Da Hosp, Dept Psychiat, 1 E Da Rd, Kaohsiung 824, Taiwan.
EM ed103750@edah.org.tw
FU Taiwan's National Science Council [NSC 89-2413-H-182-005, NSC
   90-2413-H-006-015, NSC 91-2413-H-006-006, NSC 97-2314-B-650-003-MY3];
   E-Da Hospital Taiwan [EDAHP101006, EDAHP103006]
FX This study was funded by grants from Taiwan's National Science Council
   (NSC 89-2413-H-182-005, NSC 90-2413-H-006-015, NSC 91-2413-H-006-006 and
   NSC 97-2314-B-650-003-MY3) and E-Da Hospital Taiwan (EDAHP101006 and
   EDAHP103006).
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NR 51
TC 11
Z9 12
U1 1
U2 9
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1346-3500
EI 1479-8301
J9 PSYCHOGERIATRICS
JI Psychogeriatrics
PD JUN
PY 2015
VL 15
IS 2
BP 109
EP 115
DI 10.1111/psyg.12080
PG 7
WC Geriatrics & Gerontology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology; Psychiatry
GA CK3AH
UT WOS:000356086800004
PM 25521171
DA 2025-06-11
ER

PT J
AU De Souza, AP
   Carvalho, LOT
   Pedroso, AP
   Moraes, AD
   Cipullo, MAT
   Dâmaso, AR
   Telles, MM
   Oyama, LM
   Tashima, AK
   Caranti, DA
   Ribeiro, EB
AF De Souza, Adriana P.
   Carvalho, Lorenza Oliveira T.
   Pedroso, Amanda Paula
   Moraes, Amanda De Santos
   Cipullo, Marcos Alberto Taddeo
   Damaso, Ana Raimunda
   Telles, Monica M.
   Oyama, Lila M.
   Tashima, Alexandre K.
   Caranti, Danielle A.
   Ribeiro, Eliane B.
TI An interdisciplinary therapy for lifestyle change is effective in
   improving psychological and inflammatory parameters in women with grade
   I obesity
SO ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS
LA English
DT Article
DE Anxiety; depression; inflammation; obesity; proteome
ID CARDIOMETABOLIC RISK; WEIGHT-LOSS; MARKERS; GROWTH; MCP-1
AB Obesity and depression, disorders associated with inflammation, have high incidences in women. Understanding the derangements present in the initial phase of obesity may point to factors that could help avoiding disease aggravation. The present study aimed at investigating the effects of a 6-months interdisciplinary therapy for weight loss in women with grade I obesity. Before and after the therapy, 37 middle-aged women donated blood and responded to questionnaires for depression and anxiety symptoms. Inflammatory parameters were evaluated in serum and a preliminary screening of the plasma proteome was performed. The therapy decreased anthropometric, psychological scores, and serum levels of inflammatory parameters. Depression and anxiety scores correlated positively with some inflammatory parameters. The proteomic analysis showed changes in proteins related to cholesterol metabolism and inflammatory response. Interdisciplinary therapy improves anthropometric and inflammatory statuses and ameliorating psychological symptoms. The decrease of MCP-1 levels after interdisciplinary therapy has not been reported so far, at the best of our knowledge. The present demonstration of positive associations of inflammatory markers and psychological scores indicate that these mediators may be useful to monitor psychological status in obesity. The present proteome data, although preliminary, pointed to plasma alterations indicative of improvement of inflammation after interdisciplinary therapy.
C1 [De Souza, Adriana P.; Carvalho, Lorenza Oliveira T.; Pedroso, Amanda Paula; Damaso, Ana Raimunda; Telles, Monica M.; Oyama, Lila M.; Ribeiro, Eliane B.] Univ Fed Sao Paulo UNIFESP, Dept Fisiol, Programa Posgrad Nutr, Escola Paulista Med, Rua Botucatu 862,2 Andar, BR-04023062 Sao Paulo, SP, Brazil.
   [Moraes, Amanda De Santos; Cipullo, Marcos Alberto Taddeo; Caranti, Danielle A.] Univ Fed Sao Paulo UNIFESP, Dept Biociencias, Grp Estudo Obesidade GEO, Ave Dr Epitacio Pessoa 741, BR-11045301 Santos, SP, Brazil.
   [Tashima, Alexandre K.] Univ Fed Sao Paulo UNIFESP, Dept Bioquim, Escola Paulista Med, Rua Botucatu 862, BR-04023062 Sao Paulo, SP, Brazil.
C3 Universidade Federal de Sao Paulo (UNIFESP); Universidade Federal de Sao
   Paulo (UNIFESP); Universidade Federal de Sao Paulo (UNIFESP)
RP De Souza, AP (corresponding author), Univ Fed Sao Paulo UNIFESP, Dept Fisiol, Programa Posgrad Nutr, Escola Paulista Med, Rua Botucatu 862,2 Andar, BR-04023062 Sao Paulo, SP, Brazil.
EM apsouza@unifesp.br
RI Oyama, Lila/B-7609-2012; Pedroso, Amanda/A-2310-2017; de Souza,
   Adriana/F-2767-2019; Telles, Monica/E-7470-2012; Dâmaso,
   Ana/AAT-6058-2021; Tashima, Alexandre Keiji/B-8228-2015
OI DAMASO, ANA RAIMUNDA/0000-0001-7675-7470; Tashima, Alexandre
   Keiji/0000-0002-1332-8895
FU Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
   [453924/2014-0, 001, 302165/2017, 409943/2016-9, 301322/2017-1];
   Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
   [453924/2014-0, 302165/2017, 409943/2016-9, 301322/2017-1]
FX This study was financed by the Brazilian agencies: Coordenacao de
   Aperfeicoamento de Pessoal de Nivel Superior (CAPES-Finance Code 001) ,
   Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq,
   grant 453924/2014-0 to EBR; grant 302165/2017 to LMO; grants
   409943/2016-9 and 301322/2017-1 to ARD) .
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NR 38
TC 0
Z9 0
U1 1
U2 2
PU ACAD BRASILEIRA DE CIENCIAS
PI RIO JANEIRO
PA RUA ANFILOFIO DE CARVALHO, 29, 3 ANDAR, 20030-060 RIO JANEIRO, BRAZIL
SN 0001-3765
EI 1678-2690
J9 AN ACAD BRAS CIENC
JI An. Acad. Bras. Cienc.
PY 2023
VL 95
SU 2
AR e20230365
DI 10.1590/0001-3765202320230365
PG 14
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA X1JN4
UT WOS:001096079700001
PM 37909611
OA gold
DA 2025-06-11
ER

PT J
AU Rak-Pasikowska, A
   Halucha, K
   Kaminska, M
   Niewiadomska, J
   Noszczyk-Nowak, A
   Bil-Lula, I
AF Rak-Pasikowska, Alina
   Halucha, Kornela
   Kaminska, Marta
   Niewiadomska, Joanna
   Noszczyk-Nowak, Agnieszka
   Bil-Lula, Iwona
TI The Effect of Pomegranate Peel Extract on the Oxidative and Inflammatory
   Status in the Spleens of Rats with Metabolic Syndrome
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE metabolic syndrome; syndrome X; punica granatum; polyphenols; oxidative
   stress; antioxidants; spleen; rats
ID NF-KAPPA-B; NONALCOHOLIC FATTY LIVER; INSULIN-RESISTANCE; STRESS;
   ANTIOXIDANT; OBESITY; RESVERATROL; PHYTOCHEMICALS; ACTIVATION;
   FLAVONOIDS
AB Polyphenols have antioxidant and anti-inflammatory properties and maintain the immune system in balance; therefore, the aim of the study was to investigate the effect of polyphenols present in pomegranate peel extract on the spleens of rats with metabolic syndrome. The study objects were adult male Zucker Diabetic Fatty (ZDF-Leprfa/Crl, fa/fa) rats. The rats were divided into a control group (MetS) consisting of rats with metabolic syndrome and four study groups consisting of rats with metabolic syndrome (MetS + 100 mg and MetS + 200 mg) or healthy animals (H + 100 mg and H + 200 mg) receiving polyphenol extract at a dose of 100 mg or 200 mg/kg, respectively. Concentrations of IL-6, NF-kappa B, NFATc1, Cyt-C, TNF alpha, MMP-2, ROS/RNS, and MDA were measured; the activities of GPX, SOD, CAT, MMP-2, and MMP-9 were assessed; and the expression of the BAX and BCL-2 genes was evaluated in homogenized spleens. In conclusion, pomegranate extract may lead to an increase in catalase and glutathione peroxidase activity. Additionally, it may have a reducing effect on the ROS/RNS level, leading to a reduction in the activity of SOD in the MetS groups with PPE administration. Moreover, the BCL-2 gene showed lower expression in the MetS + 100 mg group compared to the H + 100 mg group, indicating that the balance between pro- and antiapoptotic factors of the BCL-2 family may be disrupted by the metabolic syndrome promoting the proapoptotic pathway.
C1 [Rak-Pasikowska, Alina; Halucha, Kornela; Kaminska, Marta; Bil-Lula, Iwona] Wroclaw Med Univ, Fac Pharm, Dept Med Lab Diagnost, Div Clin Chem, Borowska 211A, PL-50556 Wroclaw, Poland.
   [Halucha, Kornela] Lower Silesian Oncol Pulmonol & Hematol Ctr, 12 Hirszfeld Sq, PL-53413 Wroclaw, Poland.
   [Niewiadomska, Joanna; Noszczyk-Nowak, Agnieszka] Univ Environm & Life Sci, Fac Vet Med, Dept Internal Med, Grunwaldzki Sq 47, PL-50375 Wroclaw, Poland.
   [Niewiadomska, Joanna; Noszczyk-Nowak, Agnieszka] Univ Environm & Life Sci, Fac Vet Med, Clin Dis Horses Dogs & Cats, Grunwaldzki Sq 47, PL-50375 Wroclaw, Poland.
C3 Wroclaw Medical University; Wroclaw University of Environmental & Life
   Sciences; Wroclaw University of Environmental & Life Sciences
RP Rak-Pasikowska, A (corresponding author), Wroclaw Med Univ, Fac Pharm, Dept Med Lab Diagnost, Div Clin Chem, Borowska 211A, PL-50556 Wroclaw, Poland.
EM alina.rak-pasikowska@umw.edu.pl; k.halucha@umw.edu.pl;
   joanna.niewiadomska@upwr.edu.pl; agnieszka.noszczyk-nowak@upwr.edu.pl;
   iwona.bil-lula@umw.edu.pl
RI Noszczyk-Nowak, Agnieszka/AAF-8041-2020; Bil-Lula, Iwona/ABA-2361-2021;
   Rak-Pasikowska, Alina/KYQ-9591-2024; Noszczyk-Nowak,
   Agnieszka/G-9438-2017
OI Noszczyk-Nowak, Agnieszka/0000-0001-7899-3936
FU Wroclaw Medical University;  [SUBZ.D010.24.030]
FX This study was supported by the Wroclaw Medical University grant no.
   SUBZ.D010.24.030.
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NR 88
TC 0
Z9 0
U1 5
U2 5
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD NOV
PY 2024
VL 25
IS 22
AR 12253
DI 10.3390/ijms252212253
PG 19
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA N6J8Z
UT WOS:001365389300001
PM 39596317
OA gold
DA 2025-06-11
ER

PT J
AU Asbury, EA
   Kanji, N
   Ernst, E
   Barbir, M
   Collins, P
AF Asbury, Elizabeth A.
   Kanji, Nasim
   Ernst, Edzard
   Barbir, Mahmoud
   Collins, Peter
TI Autogenic training to manage symptomology in women with chest pain and
   normal coronary arteries
SO MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY
LA English
DT Article
DE Autogenic training; Relaxation; Chest pain; Quality of life; Psychology
ID CARDIAC SYNDROME-X; TRANSCENDENTAL-MEDITATION-TECHNIQUE; POSTMENOPAUSAL
   WOMEN; ANGINA-PECTORIS; HEART-DISEASE; ARTERIOGRAMS; ANGIOGRAMS;
   RESPONSES; PERFUSION; ANXIETY
AB Objectives: To explore autogenic training (AT) as a treatment for psychological morbidity, symptomology, and physiological markers of stress among women with chest pain, a positive exercise test for myocardial ischemia, and normal coronary arteries (cardiac syndrome X).
   Design: Fifty-three women with cardiac syndrome X (mean +/- SD age, 57.1 +/- 8 years) were randomized to an 8-week AT program or symptom diary control. Symptom severity and frequency, Hospital Anxiety and Depression Scale, Spielberger State-Trait Anxiety Inventory, Cardiac Anxiety Questionnaire (CAQ), and Ferrans and Powers Quality of Life Index (QLI), blood pressure, heart rate, electrocardiogram, and plasma catecholamines were measured before and after intervention and at the 8-week follow-up.
   Results: Women who underwent AT had improved symptom frequency (8.04 +/- 10.08 vs 1.66 +/- 2.19, P < 0.001) compared with control women and reduced symtom severity (2.08 +/- 1.03 vs 1.23 +/- 1.36, P = 0.02) and frequency (6.11 +/- 3.17 vs 1.66 +/- 2.19, P < 0.001) post-AT compared with baseline within group. Within-group improvements among women who underwent AT include QLI health functioning (17.80 +/- 5.74 vs 19.41 +/- 5.19, P = 0.04) and CAQ fear (1.53 +/- 0.61 vs 1.35 +/- 0.56, P = 0.02) post-AT and QLI health functioning (17.80 +/- 5.74 vs 20.09 +/- 5.47, P = 0.01), CAQ fear (1.53 +/- 0.61 vs 1.30 +/- 0.67, P = 0.002), CAQ total (1.42 +/- 0.54 vs 1.29 +/- 0.475, P = 0.04), Spielberger State-Trait Anxiety Inventory trait anxiety (42.95 +/- 11.19 vs 38.68 +/- 11.47, P = 0.01), and QLI quality of life (20.67 +/- 5.37 vs 21.9 +/- 4.89, P = 0.02) at follow-up.
   Conclusion: An 8-week AT program improves symptom frequency, with near-significant improvements in symptom severity in women with cardiac syndrome X.
C1 [Asbury, Elizabeth A.; Collins, Peter] Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, Dept Cardiac Med, London SW3 6LY, England.
   [Ernst, Edzard] Univ Exeter, Peninsula Med Sch, Exeter, Devon, England.
   [Ernst, Edzard] Univ Plymouth, Peninsula Med Sch, Exeter, Devon, England.
   [Barbir, Mahmoud] Harefield Hosp, Royal Brompton & Harefield NHS Trust, London, England.
C3 Imperial College London; University of Exeter; University of Exeter;
   University of Plymouth; Royal Brompton Hospital; Royal Brompton &
   Harefield NHS Foundation Trust; Harefield Hospital
RP Asbury, EA (corresponding author), Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, Dept Cardiac Med, Dovehouse St, London SW3 6LY, England.
EM e.asbury@imperial.ac.uk
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NR 39
TC 31
Z9 34
U1 0
U2 9
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1072-3714
EI 1530-0374
J9 MENOPAUSE
JI Menopause-J. N. Am. Menopause Soc.
PD JAN-FEB
PY 2009
VL 16
IS 1
BP 60
EP 65
DI 10.1097/gme.0b013e318184762e
PG 6
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Obstetrics & Gynecology
GA 392WO
UT WOS:000262333100012
PM 18978640
DA 2025-06-11
ER

PT J
AU Wolkow, A
   Ferguson, S
   Aisbett, B
   Main, L
AF Wolkow, Alexander
   Ferguson, Sally
   Aisbett, Brad
   Main, Luana
TI EFFECTS OF WORK-RELATED SLEEP RESTRICTION ON ACUTE PHYSIOLOGICAL AND
   PSYCHOLOGICAL STRESS RESPONSES AND THEIR INTERACTIONS: A REVIEW AMONG
   EMERGENCY SERVICE PERSONNEL
SO INTERNATIONAL JOURNAL OF OCCUPATIONAL MEDICINE AND ENVIRONMENTAL HEALTH
LA English
DT Article
DE Sleep; Cytokines; Stress; Cortisol; Mood; Psycho-physiological
ID PITUITARY-ADRENAL AXIS; ALPHA TNF-ALPHA; CORTISOL-LEVELS; METABOLIC
   SYNDROME; ONE NIGHT; INFLAMMATORY CYTOKINES; AWAKENING RESPONSE;
   SALIVARY CORTISOL; PLASMA-CORTISOL; TRAINING STRESS
AB Emergency work can expose personnel to sleep restriction. Inadequate amounts of sleep can negatively affect physiological and psychological stress responses. This review critiqued the emergency service literature (e.g., firefighting, police/law enforcement, defense forces, ambulance/paramedic personnel) that has investigated the effect of sleep restriction on hormonal, inflammatory and psychological responses. Furthermore, it investigated if a psycho-physiological approach can help contextualize the significance of such responses to assist emergency service agencies monitor the health of their personnel. The available literature suggests that sleep restriction across multiple work days can disrupt cytokine and cortisol levels, deteriorate mood and elicit simultaneous physiological and psychological responses. However, research concerning the interaction between such responses is limited and inconclusive. Therefore, it is unknown if a psycho-physiological relationship exists and as a result, it is currently not feasible for agencies to monitor sleep restriction related stress based on psycho-physiological interactions. Sleep restriction does however, appear to be a major stressor contributing to physiological and psychological responses and thus, warrants further investigation.
C1 [Wolkow, Alexander; Aisbett, Brad; Main, Luana] Deakin Univ, Ctr Phys Act & Nutr Res, Sch Exercise & Nutr Sci, Burwood, Vic 3125, Australia.
   [Wolkow, Alexander; Ferguson, Sally; Aisbett, Brad] Bushfire Cooperat Res Ctr, East Melbourne, Australia.
   [Ferguson, Sally] Cent Queensland Univ, Appleton Inst, Wayville, Australia.
C3 Deakin University; Bushfire & Natural Hazards CRC; Central Queensland
   University
RP Wolkow, A (corresponding author), Deakin Univ, Ctr Phys Act & Nutr Res, Sch Exercise & Nutr Sci, 221 Burwood Hwy, Burwood, Vic 3125, Australia.
EM awolkow@deakin.edu.au
RI ; Aisbett, Brad/E-5178-2011; Main, Luana/L-2359-2015
OI Wolkow, Alexander/0000-0001-7845-3104; Aisbett,
   Brad/0000-0001-8077-0272; Main, Luana/0000-0002-9576-9466; Ferguson,
   Sally/0000-0002-9682-7971
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NR 113
TC 34
Z9 49
U1 1
U2 22
PU NOFER INST OCCUPATIONAL MEDICINE, POLAND
PI LODZ
PA SW TERESY 8, LODZ, 91-348, POLAND
SN 1232-1087
EI 1896-494X
J9 INT J OCCUP MED ENV
JI Int. J. Occup. Med. Environ. Health
PY 2015
VL 28
IS 2
BP 183
EP 208
PG 26
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA CG9MM
UT WOS:000353639800001
PM 26182918
OA Green Submitted, gold, Green Published
DA 2025-06-11
ER

PT J
AU Delanogare, E
   de Souza, RM
   Rosa, GK
   Guanabara, FG
   Rafacho, A
   Moreira, ELG
AF Delanogare, Eslen
   de Souza, Raul Marin
   Rosa, Giovana Karoline
   Guanabara, Fernando Garcia
   Rafacho, Alex
   Moreira, Eduardo Luiz Gasnhar
TI Enriched environment ameliorates dexamethasone effects on emotional
   reactivity and metabolic parameters in mice
SO STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS
LA English
DT Article
DE Dexamethasone; environmental enrichment; behavior dysfunctions;
   metabolic dysfunctions
ID FORCED SWIM TEST; STRESS; ANXIETY; GLUCOCORTICOIDS; LIPOLYSIS; CORTISOL;
   EXERCISE; BRAIN; DRUGS; RATS
AB Convincing evidence shows that stress is associated with the development and course of psychiatric and metabolic disorders. The hypothalamic-pituitary-adrenal (HPA) axis mediates the stress response, a cascade of events that culminate in the release of glucocorticoids from the adrenal cortex. Chronic hypercortisolism typically characterizes stress-related illnesses, such as depression, anxiety, and metabolic syndrome. Considering previous studies pointing that environmental enrichment (EE) mitigates the deleterious effects of stress on neurobiological systems, we hypothesized that EE can confer resiliency against prolonged glucocorticoid administration-induced behavioral and metabolic alterations in mice. In this regard, three-month-old male Swiss mice were exposed to a four-week period of standard environment (SE) or EE. After this period, still in the respective environments, dexamethasone was administered intraperitoneally (i.p.) at a dose of 4 mg/kg, for 21 consecutive days, in order to generate the emotional-related behavioral outcomes, as previously described. It is demonstrated herein that EE prevents the dexamethasone-induced anxiety-like and passive stress-coping behaviors, as observed in the open field and tail suspension tests. Moreover, EE mitigated the hyperproteinemia and body weight loss induced by excess dexamethasone and decreased basal glucose levels. Taken together, these results support the hypothesis that EE attenuates the effects of chronic administration of synthetic glucocorticoids in mice, a strategy that may be translated to the clinical perspective.
C1 [Delanogare, Eslen; de Souza, Raul Marin; Moreira, Eduardo Luiz Gasnhar] Univ Fed Santa Catarina, Programa Posgrad Neurociencias, Florianopolis, SC, Brazil.
   [Rosa, Giovana Karoline; Rafacho, Alex; Moreira, Eduardo Luiz Gasnhar] Univ Fed Santa Catarina, Dept Ciencias Fisiol, BR-88040900 Florianopolis, SC, Brazil.
   [Guanabara, Fernando Garcia] Univ Fed Santa Catarina, Hosp Univ Polydoro Ernani de Sao Thiago, Florianopolis, SC, Brazil.
C3 Universidade Federal de Santa Catarina (UFSC); Universidade Federal de
   Santa Catarina (UFSC); Universidade Federal de Santa Catarina (UFSC)
RP Moreira, ELG (corresponding author), Univ Fed Santa Catarina, Dept Ciencias Fisiol, BR-88040900 Florianopolis, SC, Brazil.
EM eduardo.luiz@ufsc.br
RI Moreira, Eduardo/N-6420-2014; Rafacho, Alex/O-8609-2016; Gasnhar
   Moreira, Eduardo Luiz/S-6205-2016
OI Rafacho, Alex/0000-0002-8637-6097; Gasnhar Moreira, Eduardo
   Luiz/0000-0003-2306-2207
FU Brazilian funding agency: CAPES; Brazilian funding agency: CNPq
   [Universal 424799/2018-9]; Brazilian funding agency: FAPESC
FX Research supported by grants from the Brazilian funding agencies: CAPES,
   CNPq [Universal 424799/2018-9] and FAPESC.
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NR 48
TC 13
Z9 15
U1 0
U2 7
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1025-3890
EI 1607-8888
J9 STRESS
JI Stress
PD JUL 3
PY 2020
VL 23
IS 4
BP 466
EP 473
DI 10.1080/10253890.2020.1735344
EA MAR 2020
PG 8
WC Behavioral Sciences; Endocrinology & Metabolism; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Behavioral Sciences; Endocrinology & Metabolism; Neurosciences &
   Neurology
GA MI0FX
UT WOS:000519770400001
PM 32107952
DA 2025-06-11
ER

PT J
AU Ko, JM
   So, WY
   Park, SE
AF Ko, Jae-Myun
   So, Wi-Young
   Park, Sung-Eun
TI Narrative Review of High-Intensity Interval Training: Positive Impacts
   on Cardiovascular Health and Disease Prevention
SO JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
LA English
DT Review
DE high-intensity interval training; cardiovascular disease/prevention and
   control; exercise therapy; metabolic syndrome/rehabilitation;
   cardiorespiratory fitness
ID QUALITY-OF-LIFE; INSULIN-RESISTANCE; AEROBIC FITNESS; LOW-VOLUME;
   ADAPTATIONS; WOMEN
AB Background: High-intensity interval training (HIIT) has gained recognition for its positive impacts on cardiovascular (CV) health, metabolic outcomes, mental health, and quality of life (QoL). This narrative review aims to comprehensively evaluate the efficacy of HIIT in enhancing CV health and preventing CV disease (CVD). Methods: A comprehensive search of PubMed identified 257 articles, of which 39 studies met predefined inclusion and exclusion criteria for quality assessment. Key metrics evaluated included blood pressure, vascular function, lipid profiles, body composition, and CRF. Results: HIIT significantly improved vascular function, evidenced by reductions in systolic and diastolic blood pressure and enhanced flow-mediated dilation. Improvements in cardiac function were observed through increased cardiac output and heart rate variability. Additionally, HIIT positively influenced lipid profiles, decreasing low-density lipoprotein and triglycerides while increasing high-density lipoprotein. Significant reductions in body fat and improvements in VO2peak were noted, contributing to enhanced CRF. HIIT also positively impacted mental health and QoL, reducing anxiety and depressive symptoms. Importantly, HIIT was safely and effectively applied to high-risk populations-individuals with obesity, metabolic syndrome, CVD, and cancer survivors-with a low incidence of adverse effects. Conclusions: This review highlights HIIT as an effective and safe exercise modality for improving CV health, metabolic indicators, mental health, and QoL. Future research should focus on developing tailored HIIT protocols to optimize adherence and efficacy across diverse populations, considering variations in age, sex, health status, and underlying medical conditions.
C1 [Ko, Jae-Myun] Yonsei Univ, Dept Phys Educ, Seoul 03722, South Korea.
   [So, Wi-Young] Korea Natl Univ Transportat, Coll Humanities, Dept Sports Med, Chungju Si 27469, South Korea.
   [Park, Sung-Eun] Univ Seoul, Dept Sport Sci, Seoul 02504, South Korea.
C3 Yonsei University; Korea National University of Transportation;
   University of Seoul
RP So, WY (corresponding author), Korea Natl Univ Transportat, Coll Humanities, Dept Sports Med, Chungju Si 27469, South Korea.; Park, SE (corresponding author), Univ Seoul, Dept Sport Sci, Seoul 02504, South Korea.
EM kjm1218@yonsei.ac.kr; wowso@ut.ac.kr; sungeun7741@uos.ac.kr
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TC 0
Z9 0
U1 1
U2 1
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2308-3425
J9 J CARDIOVASC DEV DIS
JI J. Cardiovasc. Dev. Dis.
PD APR 17
PY 2025
VL 12
IS 4
AR 158
DI 10.3390/jcdd12040158
PG 19
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 1WV4F
UT WOS:001475540300001
PM 40278218
OA gold
DA 2025-06-11
ER

PT J
AU Rajkumar, RP
AF Rajkumar, Ravi Philip
TI Biomarkers of Neurodegeneration in Post-Traumatic Stress Disorder: An
   Integrative Review
SO BIOMEDICINES
LA English
DT Review
DE post-traumatic stress disorder; dementia; Parkinson's disease;
   beta-amyloid; inflammation; hippocampus; white matter integrity;
   genetics
ID TRAUMATIC BRAIN-INJURY; EARLY-LIFE STRESS; HIPPOCAMPAL VOLUME; METABOLIC
   SYNDROME; SLEEP DISTURBANCES; OXIDATIVE STRESS; RISK; ASSOCIATION;
   DEMENTIA; DISEASE
AB Post-Traumatic Stress Disorder (PTSD) is a chronic psychiatric disorder that occurs following exposure to traumatic events. Recent evidence suggests that PTSD may be a risk factor for the development of subsequent neurodegenerative disorders, including Alzheimer's dementia and Parkinson's disease. Identification of biomarkers known to be associated with neurodegeneration in patients with PTSD would shed light on the pathophysiological mechanisms linking these disorders and would also help in the development of preventive strategies for neurodegenerative disorders in PTSD. With this background, the PubMed and Scopus databases were searched for studies designed to identify biomarkers that could be associated with an increased risk of neurodegenerative disorders in patients with PTSD. Out of a total of 342 citations retrieved, 29 studies were identified for inclusion in the review. The results of these studies suggest that biomarkers such as cerebral cortical thinning, disrupted white matter integrity, specific genetic polymorphisms, immune-inflammatory alterations, vitamin D deficiency, metabolic syndrome, and objectively documented parasomnias are significantly associated with PTSD and may predict an increased risk of subsequent neurodegenerative disorders. The biological mechanisms underlying these changes, and the interactions between them, are also explored. Though requiring replication, these findings highlight a number of biological pathways that plausibly link PTSD with neurodegenerative disorders and suggest potentially valuable avenues for prevention and early intervention.
C1 [Rajkumar, Ravi Philip] Jawaharlal Inst Postgrad Med Educ & Res JIPMER, Dept Psychiat, Pondicherry 605006, India.
C3 Jawaharlal Institute of Postgraduate Medical Education & Research
RP Rajkumar, RP (corresponding author), Jawaharlal Inst Postgrad Med Educ & Res JIPMER, Dept Psychiat, Pondicherry 605006, India.
EM jd0422@jipmer.ac.in
RI Rajkumar, Ravi/ABB-7319-2020
OI Rajkumar, Ravi/0000-0003-2699-7438
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NR 113
TC 13
Z9 15
U1 3
U2 6
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2227-9059
J9 BIOMEDICINES
JI Biomedicines
PD MAY 17
PY 2023
VL 11
IS 5
AR 1465
DI 10.3390/biomedicines11051465
PG 22
WC Biochemistry & Molecular Biology; Medicine, Research & Experimental;
   Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Research & Experimental Medicine;
   Pharmacology & Pharmacy
GA J7KD1
UT WOS:001011363600001
PM 37239136
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Lin, ZY
   Chan, YH
   Cheung, BMY
AF Lin, Ziying
   Chan, Yap-Hang
   Cheung, Bernard Man Yung
TI Dissecting Relations between Depression Severity, Antidepressant Use,
   and Metabolic Syndrome Components in the NHANES 2005-2020
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Article
DE metabolic syndrome components; depressive symptoms; antidepressant use;
   survey
ID CARDIOVASCULAR-DISEASE; MYOCARDIAL-INFARCTION; RISK; METAANALYSIS;
   ASSOCIATION; MECHANISMS; ANXIETY; BLOOD; PHQ-9
AB We aimed to dissect the complex relations between depressive symptoms, antidepressant use, and constituent metabolic syndrome (MetS) components in a representative U.S. population sample. A total of 15,315 eligible participants were included from 2005 to March 2020. MetS components were defined as hypertension, elevated triglycerides, reduced high-density lipoprotein cholesterol, central obesity, and elevated blood glucose. Depressive symptoms were classified as mild, moderate, or severe. Logistic regression was used to evaluate the relationship between depression severity, antidepressant use, individual MetS components and their degree of clustering. Severe depression was associated with the number of MetS components in a graded fashion. ORs for severe depression ranged from 2.08 [95%CI, 1.29-3.37] to 3.35 [95%CI, 1.57-7.14] for one to five clustered components. Moderate depression was associated with hypertension, central obesity, raised triglyceride, and elevated blood glucose (OR = 1.37 [95%CI, 1.09-1.72], 1.82 [95%CI, 1.21-2.74], 1.63 [95%CI, 1.25-2.14], and 1.37 [95%CI, 1.05-1.79], respectively). Antidepressant use was associated with hypertension (OR = 1.40, 95%CI [1.14-1.72]), raised triglyceride (OR = 1.43, 95%CI [1.17-1.74]), and the presence of five MetS components (OR = 1.74, 95%CI [1.13-2.68]) after adjusting for depressive symptoms. The depression severity and antidepressant use were associated with individual MetS components and their graded clustering. Metabolic abnormalities in patients with depression need to be recognized and treated.
C1 [Lin, Ziying; Chan, Yap-Hang; Cheung, Bernard Man Yung] Univ Hong Kong, Queen Mary Hosp, Li Ka Shing Fac Med, Sch Clin Med,Dept Med,Pokfulam, 102 Pokfulam Rd, Hong Kong, Peoples R China.
   [Cheung, Bernard Man Yung] Univ Hong Kong, State Key Lab Pharmaceut Biotechnol, Pokfulam, Hong Kong, Peoples R China.
   [Cheung, Bernard Man Yung] Univ Hong Kong, Inst Cardiovasc Sci & Med, Pokfulam, Hong Kong, Peoples R China.
C3 University of Hong Kong; University of Hong Kong; University of Hong
   Kong
RP Cheung, BMY (corresponding author), Univ Hong Kong, Queen Mary Hosp, Li Ka Shing Fac Med, Sch Clin Med,Dept Med,Pokfulam, 102 Pokfulam Rd, Hong Kong, Peoples R China.; Cheung, BMY (corresponding author), Univ Hong Kong, State Key Lab Pharmaceut Biotechnol, Pokfulam, Hong Kong, Peoples R China.; Cheung, BMY (corresponding author), Univ Hong Kong, Inst Cardiovasc Sci & Med, Pokfulam, Hong Kong, Peoples R China.
EM mycheung@hku.hk
RI Cheung, Bernard/E-9829-2010; Chan, Yap/E-9849-2010
OI Lin, Ziying/0000-0002-9388-679X
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NR 55
TC 3
Z9 3
U1 3
U2 6
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD JUN
PY 2023
VL 12
IS 12
AR 3891
DI 10.3390/jcm12123891
PG 16
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA K2LJ2
UT WOS:001014803100001
PM 37373586
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Findikli, E
   Izci, F
   Camkurt, MA
   Cetinkaya, A
   Findikli, HA
   Atmaca, M
AF Findikli, Ebru
   Izci, Filiz
   Camkurt, Mehmet Akif
   Cetinkaya, Ali
   Findikli, Huseyin Avni
   Atmaca, Murad
TI The frequency of metabolic syndrome in psychiatric patients using
   antidepressant medications
SO ANADOLU PSIKIYATRI DERGISI-ANATOLIAN JOURNAL OF PSYCHIATRY
LA English
DT Article
DE metabolic syndrome; venlafaxine; clomipramine; fluoxetine; depressive
   disorder; anxiety disorder
ID HOMEOSTASIS; PREVALENCE
AB Objective: There are limited studies investigating the metabolic syndrome (MS) in patients using antidepressants. This study examines and compares the prevalence of MS and related factors in psychiatric patients taking various antidepressants at an outpatient clinic. Methods: The study comprised a total of 70 patients using fluoxetine, paroxetine, sertralin, citalopram, essitalopram, clomipramine and venlafaxine aged 18-60 years with depressive and anxiety disorder. MS rates of patients (according to National Cholesterol Education Program-Adult Treatment Panel III-(NCEP III)) who met the study criteria were obtained. Results: In our study metabolic syndrome frequency was 32.8% in total patient groups according to NCEP-III criteria. The higher metabolic syndrome frequency was found in drug groups such as clomipramine, paroxetine and venlafaxine groups. The safest drug for metabolic syndrome was fluoxetine as seen in its relevant group. Conclusion: Conventional antidepressants may cause metabolic syndrome which is important for mortality, morbidity and quality of life of psychiatric patients.
C1 [Findikli, Ebru] Sutcuimam Univ, Med Fac, Dept Psychiat, TR-46100 Kahramanmaras, Turkey.
   [Cetinkaya, Ali] Dept Internal Med, Kahramanmaras, Turkey.
   [Izci, Filiz] Istanbul Bilim Univ, Med Fac, Dept Psychiat, Istanbul, Turkey.
   [Camkurt, Mehmet Akif] State Hosp Afsin, Dept Psychiat, Kahramanmaras, Turkey.
   [Findikli, Huseyin Avni] Adiyaman Univ, Med Fac, Dept Internal Med, Adiyaman, Turkey.
   [Atmaca, Murad] Firat Univ, Med Fac, Dept Psychiat, Elazig, Turkey.
C3 Kahramanmaras Sutcu Imam University; Demiroglu Bilim University;
   Kahramanmaras Sutcu Imam University; Afsin State Hospital; Adiyaman
   University; Firat University
RP Findikli, E (corresponding author), Sutcuimam Univ, Med Fac, Dept Psychiat, TR-46100 Kahramanmaras, Turkey.
EM ebrukanmaz@gmail.com
RI Atmaca, Murad/V-9377-2018; CETINKAYA, ALI/LGZ-1160-2024
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NR 18
TC 3
Z9 4
U1 0
U2 4
PU CUMHURIYET UNIV TIP FAK PSIKIYATRI ANABILIM DALI
PI SIVAS
PA CUMHURIYET UNIV TIP FAK PSIKIYATRI ABD, SIVAS, 58140, TURKEY
SN 1302-6631
J9 ANADOLU PSIKIYATR DE
JI Anadolu Psikiyatr. Derg.
PD APR
PY 2017
VL 18
IS 2
BP 179
EP 183
DI 10.5455/apd.214843
PG 5
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychiatry
GA EX6FK
UT WOS:000403337900010
DA 2025-06-11
ER

PT J
AU Mawhorter, S
   Crimmins, EM
   Ailshire, JA
AF Mawhorter, Sarah
   Crimmins, Eileen M.
   Ailshire, Jennifer A.
TI Housing and cardiometabolic risk among older renters and homeowners
SO HOUSING STUDIES
LA English
DT Article
DE Homeownership; older adults; housing affordability; housing conditions;
   health; cardiometabolic risk
ID SELF-RATED HEALTH; MENTAL-HEALTH; PREDICT HEALTH; TENURE; INEQUALITIES;
   AFFORDABILITY; POPULATION; HOME; ASSISTANCE; MORTALITY
AB Scholars consistently find that renters have poorer health outcomes when compared with homeowners. Health disparities between renters and homeowners likely widen over the life course, yet few studies have examined this link among older adults, and the connection is not fully understood. Homeowners' relative socio-economic advantage may explain their better health; renters also more commonly experience adverse housing conditions and financial challenges, both of which can harm health. In this paper, we analyse the extent to which socio-economic advantage, housing conditions, and financial strain explain the relationship between homeownership and health among adults over age 50, using Health and Retirement Study 2010/2012 data to assess cardiometabolic risk (CMR) levels using biomarkers for inflammation, cardiovascular health, and metabolic function. We find that people living with poor housing conditions and financial strain have higher CMR levels, even taking socio-economic advantage into account. This analysis sheds light on the housing-related health challenges of older adults, especially older renters.
C1 [Mawhorter, Sarah] Univ Southern Calif, Leonard Davis Sch Gerontol, USC UCLA Ctr Biodemog & Populat Hlth, Los Angeles, CA 90089 USA.
   [Crimmins, Eileen M.; Ailshire, Jennifer A.] Univ Southern Calif, Leonard Davis Sch Gerontol, 3715 McClintock Ave, Los Angeles, CA 90089 USA.
C3 University of Southern California; University of Southern California
RP Mawhorter, S (corresponding author), Univ Southern Calif, Leonard Davis Sch Gerontol, 3715 McClintock Ave, Los Angeles, CA 90089 USA.
EM smawhort@usc.edu
OI Mawhorter, Sarah/0000-0003-2601-0672; Ailshire,
   Jennifer/0000-0002-4476-9458
FU National Institute on Aging [P30 AG17265]; National Institute on Aging
   [U01AG009740] Funding Source: NIH RePORTER
FX Support for this analysis was provided by the National Institute on
   Aging [P30 AG17265].
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NR 62
TC 10
Z9 11
U1 2
U2 14
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 0267-3037
EI 1466-1810
J9 HOUSING STUD
JI Hous. Stud.
PD AUG 9
PY 2023
VL 38
IS 7
BP 1342
EP 1364
DI 10.1080/02673037.2021.1941792
EA JUN 2021
PG 23
WC Environmental Studies; Regional & Urban Planning; Urban Studies
WE Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public Administration; Urban Studies
GA N3VY9
UT WOS:000674790300001
PM 37849684
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Lam-Hine, T
   Riddell, CA
   Bradshaw, PT
   Omi, M
   Allen, AM
AF Lam-Hine, Tracy
   Riddell, Corinne A.
   Bradshaw, Patrick T.
   Omi, Michael
   Allen, Amani M.
TI Racial differences in associations between adverse childhood experiences
   and physical, mental, and behavioral health
SO SSM-POPULATION HEALTH
LA English
DT Article
DE Adverse childhood experiences; Racial groups; Asthma; Anxiety
ID LIFE-COURSE PATHWAYS; SUBSTANCE USE; NEIGHBORHOOD DISADVANTAGE;
   SOCIOECONOMIC-STATUS; DISPARITIES; RISK; COLLEGE; ADOLESCENCE;
   DEPRESSION; STRESS
AB Purpose: Adverse childhood experiences (ACEs) are associated with poor adulthood health. Multiracial people have elevated mean ACEs scores and risk of several outcomes. We aimed to determine whether this group should be targeted for prevention efforts.Methods: We analyzed three waves (1994-2009) of the National Longitudinal Study of Adolescent to Adult Health (n = 12,372) in 2023, estimating associations between four or more ACEs and physical (metabolic syndrome, hypertension, asthma), mental (anxiety, depression), and behavioral (suicidal ideation, drug use) outcomes. We estimated adjusted risk ratios for each outcome in modified Poisson models interacting race and ACEs. We used the interaction contrast to estimate race-specific excess cases per 1000 relative to Multiracial participants.Results: Excess case estimates of asthma were smaller for White (-123 cases, 95% CI:-251,-4), Black (-141, 95% CI:-285,-6), and Asian (-169, 95% CI:-334,-7) participants compared to Multiracial participants. Black (-100, 95% CI:-189,-10), Asian (-163, 95% CI:-247,-79) and Indigenous (-144, 95% CI:-252,-42) participants had fewer excess cases of and weaker relative scale association with anxiety compared to Multiracial participants.Conclusions: Adjusted associations with asthma and anxiety appear stronger for Multiracial people. Existing ACEs prevention strategies should be tailored to support Multiracial youth and families.
C1 [Lam-Hine, Tracy] Stanford Univ, Sch Med, Div Epidemiol & Populat Hlth, Dept Pediat, 1701 Page Mill Rd, Palo Alto, CA USA.
   [Riddell, Corinne A.] Univ Calif Berkeley, Sch Publ Hlth, Div Biostat, 2121 Berkeley Way West, Berkeley, CA USA.
   [Riddell, Corinne A.; Bradshaw, Patrick T.; Allen, Amani M.] Univ Calif Berkeley, Sch Publ Hlth, Div Epidemiol, 2121 Berkeley Way West, Berkeley, CA 94720 USA.
   [Omi, Michael] Univ Calif Berkeley, Dept Ethn Studies, 506 Social Sci Bldg, Berkeley, CA USA.
   [Allen, Amani M.] Univ Calif Berkeley, Div Community Hlth Sci, Sch Publ Hlth, 2121 Berkeley Way West, Berkeley, CA USA.
C3 Stanford University; University of California System; University of
   California Berkeley; University of California System; University of
   California Berkeley; University of California System; University of
   California Berkeley; University of California System; University of
   California Berkeley
RP Allen, AM (corresponding author), Univ Calif Berkeley, Sch Publ Hlth, Div Epidemiol, 2121 Berkeley Way West, Berkeley, CA 94720 USA.
EM lamhine@stanford.edu; c.riddell@berkeley.edu; pbradshaw@berkeley.edu;
   omi@berkeley.edu; amaniallen@berkeley.edu
RI Lam-Hine, Tracy/IUN-3451-2023; Bradshaw, Patrick/AAJ-7529-2021
OI Lam-Hine, Tracy/0000-0001-9040-2991
FU NIH-NCATS-CTSA [UL1TR003142, 75D30122P12974]; Centers for Disease
   Control and Prevention
FX <B>Funding</B> TLH was supported by NIH-NCATS-CTSA grant UL1TR003142 and
   contract 75D30122P12974 with the Centers for Disease Control and
   Prevention.
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NR 93
TC 14
Z9 15
U1 2
U2 5
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 2352-8273
J9 SSM-POPUL HLTH
JI SSM-Popul. Health
PD DEC
PY 2023
VL 24
AR 101524
DI 10.1016/j.ssmph.2023.101524
EA OCT 2023
PG 8
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA X3FA1
UT WOS:001097332100001
PM 37860706
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Garg, A
   Malviya, N
   Strunk, A
   Wright, S
   Alavi, A
   Alhusayen, R
   Alikhan, A
   Daveluy, SD
   Delorme, I
   Goldfarb, N
   Gulliver, W
   Hamzavi, I
   Jaleel, T
   Kimball, AB
   Kirby, JS
   Kirchhof, MG
   Lester, J
   Lev-Tov, H
   Lowes, MA
   Micheletti, R
   Orenstein, LA
   Piguet, V
   Sayed, C
   Tan, J
   Naik, HB
AF Garg, Amit
   Malviya, Neeta
   Strunk, Andrew
   Wright, Shari
   Alavi, Afsaneh
   Alhusayen, Raed
   Alikhan, Ali
   Daveluy, Steven D.
   Delorme, Isabelle
   Goldfarb, Noah
   Gulliver, Wayne
   Hamzavi, Iltefat
   Jaleel, Tarannum
   Kimball, Alexa B.
   Kirby, Joslyn S.
   Kirchhof, Mark G.
   Lester, Janice
   Lev-Tov, Hadar
   Lowes, Michelle A.
   Micheletti, Robert
   Orenstein, Lauren A.
   Piguet, Vincent
   Sayed, Christopher
   Tan, Jerry
   Naik, Haley B.
TI Comorbidity screening in hidradenitis suppurativa: Evidence-based
   recommendations from the US and Canadian Hidradenitis Suppurativa
   Foundations
SO JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
LA English
DT Article
DE acne; cardiovascular disease; comorbidity; Crohn's disease; depression;
   dermatologist; diabetes mellitus; dissecting cellulitis of the scalp;
   down syndrome; dyslipidemia; generalized anxiety disorder; guidelines;
   herpes zoster; hidradenitis suppurativa; hypertension; inflammatory
   bowel disease; lymphoma; metabolic syndrome; North America; obesity;
   pilonidal disease; polycystic ovary syndrome; pyoderma gangrenosum;
   screening; sexual dysfunction; smoking; spondyloarthritis; substance
   use; suicide; systemic; ulcerative colitis
ID INFLAMMATORY-BOWEL-DISEASE; METABOLIC SYNDROME; PREVALENCE; RISK;
   POPULATION; HEALTH; ASSOCIATION; DEPRESSION; BURDEN; COHORT
AB Background: Hidradenitis suppurativa (HS) is associated with comorbidities that contribute to poor health, impaired life quality, and mortality risk.
   Objective: To provide evidence-based screening recommendations for comorbidities linked to HS.
   Methods: Systematic reviews were performed to summarize evidence on the prevalence and incidence of 30 comorbidities in patients with HS relative to the general population. The screening recommendation for each comorbidity was informed by the consistency and quality of existing studies, disease prevalence, and magnitude of association, as well as benefits, harms, and feasibility of screening. The level of evidence and strength of corresponding screening recommendation were graded by using the Strength of Recommendation Taxonomy (SORT) criteria.
   Results: Screening is recommended for the following comorbidities: acne, dissecting cellulitis of the scalp, pilonidal disease, pyoderma gangrenosum, depression, generalized anxiety disorder, suicide, smoking, substance use disorder, polycystic ovary syndrome, obesity, dyslipidemia, diabetes mellitus, metabolic syndrome, hypertension, cardiovascular disease, inflammatory bowel disease, spondyloarthritis, and sexual dysfunction. It is also recommended to screen patients with Down syndrome for HS. The decision to screen for specific comorbidities may vary with patient risk factors. The role of the dermatologist in screening varies according to comorbidity.
   Limitations: Screening recommendations represent one component of a comprehensive care strategy.
   Conclusions: Dermatologists should support screening efforts to identify comorbid conditions in HS.
C1 [Garg, Amit; Malviya, Neeta; Strunk, Andrew; Wright, Shari] Donald & Barbara Zucker Sch Med Hofstra Northwell, Dept Dermatol, New Hyde Pk, NY 11042 USA.
   [Alavi, Afsaneh; Alhusayen, Raed; Piguet, Vincent] Univ Toronto, Women Coll Hosp, Fac Med, Div Dermatol, Toronto, ON, Canada.
   [Alhusayen, Raed] Univ Toronto, Dept Med, Toronto, ON, Canada.
   [Alhusayen, Raed] Univ Toronto, Sunnybrook Res Inst, Toronto, ON, Canada.
   [Alikhan, Ali] Sutter Med Fdn, Dept Dermatol, Sacramento, CA USA.
   [Daveluy, Steven D.] Wayne State Univ, Sch Med, Dept Dermatol, Detroit, MI 48201 USA.
   [Delorme, Isabelle] Dr Isabelle Delorme Inc, Dermatol, Drummondville, PQ, Canada.
   [Goldfarb, Noah] Minneapolis Vet Affairs Hlth Care Syst, Dept Internal Med, Minneapolis, MN USA.
   [Goldfarb, Noah] Minneapolis Vet Affairs Hlth Care Syst, Dept Dermatol, Minneapolis, MN USA.
   [Gulliver, Wayne] Mem Univ Newfoundland, Fac Med, St John, NL, Canada.
   [Hamzavi, Iltefat] Henry Ford Hosp, Multicultural Dermatol Ctr, Dept Dermatol, Detroit, MI 48202 USA.
   [Jaleel, Tarannum] Duke Univ, Sch Med, Dept Dermatol, Durham, NC USA.
   [Kimball, Alexa B.] Beth Israel Deaconess Med Ctr, Harvard Med Fac Phys, Boston, MA 02215 USA.
   [Kirby, Joslyn S.] Penn State Milton S Hershey Med Ctr, Hershey, PA USA.
   [Kirchhof, Mark G.] Univ Ottawa, Fac Med, Div Dermatol, Ottawa, ON, Canada.
   [Kirchhof, Mark G.] Ottawa Hosp, Ottawa, ON, Canada.
   [Lester, Janice] Donald & Barbara Zucker Sch Med Hofstra Northwell, Clin Med Lib, New Hyde Pk, NY 11042 USA.
   [Lev-Tov, Hadar] Univ Miami, Miller Sch Med, Dr Phillip Frost Dept Dermatol & Cutaneous Surg, Miami, FL 33136 USA.
   [Lowes, Michelle A.] Rockefeller Univ, 1230 York Ave, New York, NY 10021 USA.
   [Micheletti, Robert] Univ Penn, Perelman Sch Med, Dept Dermatol, Philadelphia, PA 19104 USA.
   [Micheletti, Robert] Univ Penn, Perelman Sch Med, Dept Med, Philadelphia, PA 19104 USA.
   [Orenstein, Lauren A.] Emory Univ, Sch Med, Dept Dermatol, Atlanta, GA 30322 USA.
   [Piguet, Vincent] Womens Coll Hosp, Toronto, ON, Canada.
   [Sayed, Christopher] Univ N Carolina, Sch Med, Dept Dermatol, Chapel Hill, NC 27515 USA.
   [Tan, Jerry] Univ Western Ontario, Dept Internal Med, Windsor Campus, Windsor, ON, Canada.
   [Naik, Haley B.] Univ Calif San Francisco, Dept Dermatol, San Francisco, CA USA.
C3 Northwell Health; University of Toronto; Womens College Hospital;
   University of Toronto; University of Toronto; Sunnybrook Health Science
   Center; Sunnybrook Research Institute; Wayne State University; US
   Department of Veterans Affairs; Veterans Health Administration (VHA);
   Minneapolis VA Health Care System; US Department of Veterans Affairs;
   Veterans Health Administration (VHA); Minneapolis VA Health Care System;
   Memorial University Newfoundland; Henry Ford Health System; Henry Ford
   Hospital; Duke University; Harvard University; Harvard University
   Medical Affiliates; Beth Israel Deaconess Medical Center; Harvard
   Medical School; Pennsylvania Commonwealth System of Higher Education
   (PCSHE); Pennsylvania State University; Penn State Health; University of
   Ottawa; University of Ottawa; Ottawa Hospital Research Institute;
   Northwell Health; University of Miami; Rockefeller University;
   University of Pennsylvania; University of Pennsylvania; Emory
   University; University of Toronto; Womens College Hospital; University
   of North Carolina; University of North Carolina Chapel Hill; University
   of North Carolina School of Medicine; Western University (University of
   Western Ontario); University of California System; University of
   California San Francisco
RP Garg, A (corresponding author), Donald & Barbara Zucker Sch Med Hofstra Northwell, 1991 Marcus Ave,Suite 300, New Hyde Pk, NY 11042 USA.
EM amgarg@northwell.edu
RI Sayed, Christopher/AAC-3343-2020; Gulliver, Professor
   Wayne/ACM-2713-2022; Goldfarb, Noah/AAA-3082-2022; Hamzavi,
   Iltefat/AAW-7320-2021; Garg, Amit/JEO-9043-2023
OI Sayed, Christopher/0000-0003-3201-4637; Piguet,
   Vincent/0000-0001-6079-4517; Goldfarb, Noah/0000-0003-1070-0652; Garg,
   Amit/0000-0003-0886-6856; Kimball, Alexandra/0000-0001-9405-0479;
   LESTER, JANICE/0000-0003-1585-8248
FU Building Interdisciplinary Research Careers in Women's Health of the
   National Institutes of Health [K12D085850]; National Institutes of
   Health [NIAMS K32 AR074531]; National Institute of Arthritis and
   Musculoskeletal and Skin Diseases [K23AR074531] Funding Source: NIH
   RePORTER
FX Dr Orenstein is supported in part by Building Interdisciplinary Research
   Careers in Women's Health of the National Institutes of Health
   (K12D085850). Dr Naik is supported in part by the National Institutes of
   Health (NIAMS K32 AR074531).
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NR 75
TC 143
Z9 144
U1 5
U2 26
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0190-9622
EI 1097-6787
J9 J AM ACAD DERMATOL
JI J. Am. Acad. Dermatol.
PD MAY
PY 2022
VL 86
IS 5
BP 1092
EP 1101
DI 10.1016/j.jaad.2021.01.059
EA APR 2022
PG 10
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 3T4TW
UT WOS:000840269600020
PM 33493574
OA hybrid, Green Accepted, Green Published
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Babic, D
   Maslov, B
   Martinac, M
   Nikolic, K
   Uzun, S
   Kozumplik, O
AF Babic, Dragan
   Maslov, Boris
   Martinac, Marko
   Nikolic, Katica
   Uzun, Suzana
   Kozumplik, Oliver
TI BIPOLAR DISORDER AND METABOLIC SYNDROME: COMORBIDITY OR SIDE EFFECTS OF
   TREATMENT OF BIPOLAR DISORDER
SO PSYCHIATRIA DANUBINA
LA English
DT Article; Proceedings Paper
CT 2nd Croatian Congress on Side Effects of Psychotropics
CY MAR 11-14, 2010
CL Rovinj, CROATIA
DE metabolic syndrome; bipolar disorders; prevalence; side effects;
   cornorbidity
ID POSTTRAUMATIC-STRESS-DISORDER; DEPRESSION; SYMPTOMS; VETERANS; ADULTS;
   RISK
AB Objective: There is evidence that people with mental disorders are more likely to suffer from metabolic syndrome. In the last decades there has been an increase in interest for researching metabolic syndrome in psychiatric patients and plenty of evidence about their association. However, investigations on the prevalence of metabolic syndrome in patients with bipolar disorder are still surprisingly rare. The aim of this paper is to analyze comorbidity of bipolar disorder and metabolic syndrome, and the association of treatment with antipsychotics and mood stabilizers with metabolic syndrome, as well as to point out the necessity of appropriate preventive measures and treatment of metabolic syndrome in patient with bipolar disorder.
   Content analysis of literature: Literature research included structured searches of Medline and other publications on the subject of comorbidity of bipolar disorder and metabolic syndrome, and the association of treatment with antipsychotics and mood stabilizers with metabolic syndrome, as well as preventive measures and treatment of metabolic syndrome in patient with bipolar disorder.
   Conclusion: Metabolic syndrome is present in 8-56% of patients suffering from bipolar disorder. Metabolic syndrome in patients with bipolar disorder can significantly contribute to morbidity and mortality, and it is certainly necessary to think of it, to take adequate preventive and therapeutic measures in treating its individual components. Further investigation on association between bipolar disorder and metabolic disorder, and the association of treatment with antipsychotics and mood stabilizers with metabolic syndrome are necessary.
C1 [Babic, Dragan] Univ Mostar, Dept Psychiat, Sch Med, Mostar 88000, Bosnia & Herceg.
   [Babic, Dragan; Maslov, Boris; Nikolic, Katica] Univ Clin Hosp Mostar, Psychiat Clin, Mostar, Bosnia & Herceg.
   [Uzun, Suzana; Kozumplik, Oliver] Vrapce Psychiat Hosp, Univ Dept, Zagreb 10090, Croatia.
C3 University of Mostar; University of Mostar
RP Babic, D (corresponding author), Univ Mostar, Dept Psychiat, Sch Med, Mostar 88000, Bosnia & Herceg.
EM dragan.babic@tel.net.ba
OI Martinac, Marko/0000-0001-9144-6427
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NR 28
TC 26
Z9 27
U1 2
U2 13
PU MEDICINSKA NAKLADA
PI ZAGREB
PA VLASKA 69, HR-10000 ZAGREB, CROATIA
SN 0353-5053
J9 PSYCHIAT DANUB
JI Psychiatr. Danub.
PD FEB
PY 2010
VL 22
IS 1
BP 75
EP 78
PG 4
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI); Conference Proceedings Citation Index - Social Science &amp; Humanities (CPCI-SSH); Conference Proceedings Citation Index - Science (CPCI-S)
SC Psychiatry
GA 829EB
UT WOS:000295558400012
PM 20305595
DA 2025-06-11
ER

PT J
AU McIntyre, RS
   Liauw, S
   Taylor, VH
AF McIntyre, Roger S.
   Liauw, Samantha
   Taylor, Valerie H.
TI Depression in the workforce: the intermediary effect of medical
   comorbidity
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Workforce disability; Depression; Medical comorbidity; Obesity;
   Diabetes; Cardiovascular disease
ID BODY-MASS INDEX; BIPOLAR DISORDER; MENTAL-HEALTH; WORK PRODUCTIVITY;
   ECONOMIC BURDEN; WORKPLACE DEPRESSION; DISEASE MANAGEMENT; METABOLIC
   SYNDROME; STRESS-MANAGEMENT; MOOD DISORDERS
AB Background: It is amply documented that mood disorders adversely affect job satisfaction, workforce productivity, and absenteeism/presenteeism. It is also well documented that mood disorders are an independent risk factor for several chronic medical disorders (e.g., obesity, diabetes mellitus, cardiovascular disease). Emerging evidence indicates that the workforce dysfunction associated with depression is partially mediated by medical comorbidity.
   Methods: We conducted a PubMed search of all English-language articles published between 2005 and July 2009 with the following search terms: major depressive disorder and depression, cross-referenced with work productivity, disability, economic cost, absenteeism, presenteeism, and medical comorbidity. Articles selected for review were based on adequacy of sample size, the use of standardized experimental procedures, validated assessment measures, and overall manuscript quality.
   Results: Mood disorders are the most impairing condition amongst working adults. It is estimated that approximately 35-50% of employees with depression will take short-term disability leave at some point during their job tenure. Moreover, 15-20% of the workforce will receive short-term disability benefits during any given year; the annual income of individuals affected by depression is reduced by approximately 10% when compared to unaffected employees. Chronic stress-sensitive conditions independently contribute to workforce maladjustment and associated disability. The mood disorder population is differentially affected by several stress-related medical conditions resulting in greater impairment in the workforce.
   Conclusion: Disability modelling in the depressed employee has emphasized the complex interrelationship between depressive symptoms, workforce stress, and consequent disability. A more refined model must include the effects of chronic medical conditions as a powerful mediator and/or moderator of workforce impairment. Multidisciplinary interventions have been demonstrated to reduce, but not eliminate workforce disability related to depression, underscoring the need for elucidating other modifiable factors. Screening, treatment, and prevention initiatives need to target chronic medical conditions in depressed employees in order to reduce overall workforce disability. (C) 2010 Elsevier B.V. All rights reserved.
C1 [McIntyre, Roger S.] Univ Toronto, Dept Psychiat, Toronto, ON M5T 2S8, Canada.
   [McIntyre, Roger S.] Univ Toronto, Dept Pharmacol, Toronto, ON M5T 2S8, Canada.
   [McIntyre, Roger S.; Liauw, Samantha] Univ Hlth Network, Mood Disorders Psychopharmacol Unit, Toronto, ON, Canada.
   [McIntyre, Roger S.] Univ Toronto, Inst Med Sci, Toronto, ON M5T 2S8, Canada.
   [Liauw, Samantha] McGill Univ, Montreal, PQ, Canada.
   [Taylor, Valerie H.] McMaster Univ, Dept Psychiat, Hamilton, ON L8S 4L8, Canada.
C3 University of Toronto; University of Toronto; University of Toronto;
   University Health Network Toronto; University of Toronto; McGill
   University; McMaster University
RP McIntyre, RS (corresponding author), Univ Toronto, Dept Psychiat, 399 Bathurst St, Toronto, ON M5T 2S8, Canada.
EM roger.mcintyre@uhn.on.ca
RI McIntyre, Roger/AAU-1000-2020; Taylor, Valerie/H-6242-2015
OI Taylor, Valerie/0000-0002-8948-638X
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NR 77
TC 45
Z9 52
U1 0
U2 29
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD JAN
PY 2011
VL 128
SU 1
BP S29
EP S36
DI 10.1016/S0165-0327(11)70006-4
PG 8
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA 724HL
UT WOS:000287566600005
PM 21220078
DA 2025-06-11
ER

PT J
AU Keshavjee, B
   Lambelet, V
   Coppola, H
   Viertl, D
   Prior, JO
   Kappeler, L
   Armengaud, JB
   Chouraqui, JP
   Chehade, H
   Vanderriele, PE
   Allouche, M
   Balsiger, A
   Sarre, A
   Peyter, AC
   Simeoni, U
   Yzydorczyk, C
AF Keshavjee, Basile
   Lambelet, Valentine
   Coppola, Hanna
   Viertl, David
   Prior, John O.
   Kappeler, Laurent
   Armengaud, Jean-Baptiste
   Chouraqui, Jean-Pierre
   Chehade, Hassib
   Vanderriele, Paul-Emmanuel
   Allouche, Manon
   Balsiger, Anne
   Sarre, Alexandre
   Peyter, Anne-Christine
   Simeoni, Umberto
   Yzydorczyk, Catherine
TI Stress-Induced Premature Senescence Related to Oxidative Stress in the
   Developmental Programming of Nonalcoholic Fatty Liver Disease in a Rat
   Model of Intrauterine Growth Restriction
SO ANTIOXIDANTS
LA English
DT Article
DE intrauterine growth restriction; metabolic syndrome; developmental
   programming; nonalcoholic fatty liver disease; oxidative stress;
   cellular senescence
ID ACTIVATED PROTEIN-KINASE; LOW-BIRTH-WEIGHT; ELEMENT-BINDING PROTEIN-1;
   METABOLIC SYNDROME; HEPATIC STEATOSIS; GENE-EXPRESSION; ENDOTHELIAL
   DYSFUNCTION; TRANSCRIPTION FACTORS; CELLULAR SENESCENCE;
   INSULIN-RESISTANCE
AB Metabolic syndrome (MetS) refers to cardiometabolic risk factors, such as visceral obesity, dyslipidemia, hyperglycemia/insulin resistance, arterial hypertension and non-alcoholic fatty liver disease (NAFLD). Individuals born after intrauterine growth restriction (IUGR) are particularly at risk of developing metabolic/hepatic disorders later in life. Oxidative stress and cellular senescence have been associated with MetS and are observed in infants born following IUGR. However, whether these mechanisms could be particularly associated with the development of NAFLD in these individuals is still unknown. IUGR was induced in rats by a maternal low-protein diet during gestation versus. a control (CTRL) diet. In six-month-old offspring, we observed an increased visceral fat mass, glucose intolerance, and hepatic alterations (increased transaminase levels, triglyceride and neutral lipid deposit) in male rats with induced IUGR compared with the CTRL males; no differences were found in females. In IUGR male livers, we identified some markers of stress-induced premature senescence (SIPS) (lipofuscin deposit, increased protein expression of p21(WAF), p16(INK4a) and Acp53, but decreased pRb/Rb ratio, foxo-1 and sirtuin-1 protein and mRNA expression) associated with oxidative stress (higher superoxide anion levels, DNA damages, decreased Cu/Zn SOD, increased catalase protein expression, increased nfe2 and decreased keap1 mRNA expression). Impaired lipogenesis pathways (decreased pAMPK/AMPK ratio, increased pAKT/AKT ratio, SREBP1 and PPAR gamma protein expression) were also observed in IUGR male livers. At birth, no differences were observed in liver histology, markers of SIPS and oxidative stress between CTRL and IUGR males. These data demonstrate that the livers of IUGR males at adulthood display SIPS and impaired liver structure and function related to oxidative stress and allow the identification of specific therapeutic strategies to limit or prevent adverse consequences of IUGR, particularly metabolic and hepatic disorders.
C1 [Keshavjee, Basile; Lambelet, Valentine; Coppola, Hanna; Armengaud, Jean-Baptiste; Chehade, Hassib; Allouche, Manon; Balsiger, Anne; Sarre, Alexandre; Simeoni, Umberto; Yzydorczyk, Catherine] Univ Lausanne, Dept Woman Mother Child, Div Pediat, DOHaD Lab, CH-1011 Lausanne, Switzerland.
   [Keshavjee, Basile; Lambelet, Valentine; Coppola, Hanna; Viertl, David; Prior, John O.; Armengaud, Jean-Baptiste; Chouraqui, Jean-Pierre; Chehade, Hassib; Allouche, Manon; Balsiger, Anne; Sarre, Alexandre; Peyter, Anne-Christine; Simeoni, Umberto; Yzydorczyk, Catherine] Lausanne Univ Hosp, CH-1011 Lausanne, Switzerland.
   [Viertl, David; Prior, John O.] Univ Lausanne, Dept Nucl Med & Mol Imaging, CH-1011 Lausanne, Switzerland.
   [Kappeler, Laurent] Sorbonne Univ, CRSA, INSERM, F-75000 Paris, France.
   [Kappeler, Laurent] Sorbonne Univ, IHU ICAN Inst Cardiometab & Nutr, F-75000 Paris, France.
   [Chouraqui, Jean-Pierre] Univ Lausanne, Dept Woman Mother Child, Pediat Nutr & Gastroenterol Unit, CH-1011 Lausanne, Switzerland.
   [Vanderriele, Paul-Emmanuel] Univ Lausanne, Natl Ctr Competence Res Kidney, Dept Biomed Sci, CH-1011 Lausanne, Switzerland.
   [Peyter, Anne-Christine] Univ Lausanne, Dept Woman Mother Child, Neonatal Res Lab, Clin Neonatol, CH-1011 Lausanne, Switzerland.
C3 University of Lausanne; University of Lausanne; Centre Hospitalier
   Universitaire Vaudois (CHUV); University of Lausanne; Institut National
   de la Sante et de la Recherche Medicale (Inserm); Sorbonne Universite;
   Sorbonne Universite; University of Lausanne; University of Lausanne;
   University of Lausanne
RP Yzydorczyk, C (corresponding author), Univ Lausanne, Dept Woman Mother Child, Div Pediat, DOHaD Lab, CH-1011 Lausanne, Switzerland.; Yzydorczyk, C (corresponding author), Lausanne Univ Hosp, CH-1011 Lausanne, Switzerland.
EM catherine.yzydorczyk@chuv.ch
RI Sarre, Alexandre/HNB-4369-2023; Kappeler, Laurent/N-6327-2017; Prior,
   John/I-5364-2017
OI Prior, John/0000-0003-1429-1374; Chouraqui,
   Jean-Pierre/0000-0002-6488-922X; Vanderriele, Paul
   Emmanuel/0000-0002-8581-8471; YZYDORCZYK, Catherine/0000-0002-0617-7558;
   Viertl, David/0000-0001-5203-0939; Sarre, Alexandre/0009-0008-7374-8278;
   Peyter, Anne-Christine/0000-0003-2051-1126; Armengaud,
   Jean-Baptiste/0000-0002-2276-623X
FU "Association pour information et la recherche sur les maladies renales
   genetiques" (AIRG-Switzerland)
FX This research was funded by a grant from the "Association pour
   information et la recherche sur les maladies renales genetiques"
   (AIRG-Switzerland).
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NR 117
TC 11
Z9 12
U1 1
U2 15
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD SEP
PY 2022
VL 11
IS 9
AR 1695
DI 10.3390/antiox11091695
PG 26
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA 4Q5ZS
UT WOS:000856161600001
PM 36139771
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Howarter, AD
   Bennett, KK
AF Howarter, Alisha D.
   Bennett, Kymberley K.
TI Perceived Discrimination and Health-Related Quality of Life: Testing the
   Reserve Capacity Model in Hispanic Americans
SO JOURNAL OF SOCIAL PSYCHOLOGY
LA English
DT Article
DE health-related quality of life; Hispanic Americans; perceived
   discrimination; reserve capacity model
ID RACE-BASED DISCRIMINATION; SOCIOECONOMIC-STATUS; PHYSICAL HEALTH;
   METABOLIC SYNDROME; AFRICAN-AMERICANS; SOCIAL SUPPORT; BLOOD-PRESSURE;
   HEART-DISEASE; TRAIT ANXIETY; RACISM
AB This study tested aspects of the Reserve Capacity Model (Gallo & Matthews, 2003; Gallo, Penedo Espinosa de los Monteros, & Arguelles, 2009) as a means of understanding disparities in health-related quality of life appraisals among Hispanic Americans. Questionnaire data were collected from 236 Hispanic participants, including measures of perceived discrimination, optimism, social support, symptoms of trait anxiety, and physical and mental health-related quality of life. Path analysis indicated direct, negative associations between perceived discrimination and both forms of health-related quality of life. Results also showed that these relationships were partially mediated by the reserve capacity variable of optimism and by symptoms of anxiety, though evidence for mediation by anxiety was stronger than for optimism. Findings suggest that perceived discrimination depletes intrapersonal reserves in Hispanic Americans, which, in turn, induces negative emotions. Implications for community-level interventions are discussed.
C1 [Howarter, Alisha D.] Univ Missouri, Dept Psychol, Clin Hlth Psychol Program, Kansas City, MO 64110 USA.
C3 University of Missouri System; University of Missouri Kansas City
RP Bennett, KK (corresponding author), Univ Missouri, Dept Psychol, Clin Hlth Psychol Program, 5030 Cherry St,Room 302, Kansas City, MO 64110 USA.
EM bennettkk@umkc.edu
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NR 50
TC 22
Z9 37
U1 0
U2 30
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 0022-4545
EI 1940-1183
J9 J SOC PSYCHOL
JI J. Soc. Psychol.
PY 2013
VL 153
IS 1
BP 62
EP 79
DI 10.1080/00224545.2012.703973
PG 18
WC Psychology, Social
WE Social Science Citation Index (SSCI)
SC Psychology
GA 041ZD
UT WOS:000311439800007
PM 23421006
DA 2025-06-11
ER

PT J
AU McGraw, LK
   Turner, BS
   Stotts, NA
   Dracup, KA
AF McGraw, Leigh K.
   Turner, Barbara S.
   Stotts, Nancy A.
   Dracup, Kathleen A.
TI A review of cardiovascular risk factors in US military personnel
SO JOURNAL OF CARDIOVASCULAR NURSING
LA English
DT Review
DE atherosclerosis; cardiovascular disease; military personnel;
   psychophysiology
ID CORONARY-HEART-DISEASE; HIGH-DENSITY-LIPOPROTEIN; INSULIN-RESISTANCE;
   METABOLIC SYNDROME; ARTERY-DISEASE; MENTAL STRESS;
   MYOCARDIAL-INFARCTION; PSYCHOLOGICAL STRESS; CHOLESTEROL LEVELS;
   BLOOD-PRESSURE
AB As the civilian population exhibits increasing trends in major cardiovascular (CV) risk factors in younger age groups, the US military is observing similar trends. These worrisome developments are seen even in young adulthood. Despite the need for a fit, combat-ready force, increases in CV risk are increasingly evident in the military population. This review provides an overview of coronary artery disease in the young and the prevalence of risk factors in the military population. With increases in current military operations in an acutely stressful environment, the role of stress and the manifestation of CV disease are also examined.
C1 [McGraw, Leigh K.; Stotts, Nancy A.; Dracup, Kathleen A.] Univ Calif San Francisco, Dept Physiol Nursing, San Francisco, CA 94143 USA.
   [Turner, Barbara S.] Duke Univ, Sch Nursing, Durham, NC USA.
C3 University of California System; University of California San Francisco;
   Duke University
RP McGraw, LK (corresponding author), 5506 80th Ave Court W, University Pl, WA 98467 USA.
EM leigh.mcgraw@ucsf.edu
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NR 65
TC 32
Z9 36
U1 0
U2 7
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0889-4655
EI 1550-5049
J9 J CARDIOVASC NURS
JI J. Cardiovasc. Nurs.
PD JUL-AUG
PY 2008
VL 23
IS 4
BP 338
EP 344
DI 10.1097/01.JCN.0000317437.75081.e7
PG 7
WC Cardiac & Cardiovascular Systems; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Cardiovascular System & Cardiology; Nursing
GA 322YG
UT WOS:000257410600005
PM 18596497
DA 2025-06-11
ER

PT J
AU Beach, SRH
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   Carter, SE
   Simons, RL
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AF Beach, Steven R. H.
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   Simons, Ronald L.
   Gibbons, Frederick X.
   Philibert, Robert A.
TI Methylation of FKBP5 is associated with accelerated DNA methylation
   ageing and cardiometabolic risk: replication in young-adult and
   middle-aged Black Americans
SO EPIGENETICS
LA English
DT Article
DE Health disparities; minority health; risk factors; DNA methylation; HPA
   axis
ID CARDIOVASCULAR-DISEASE RISK; RACIAL-DIFFERENCES; LIPOPROTEIN SUBCLASS;
   AFRICAN-AMERICANS; LIFE-SPAN; STRESS; CHILDHOOD; DISCRIMINATION;
   SUSCEPTIBILITY; CONTRIBUTES
AB Methylation of FKBP5 is involved in the regulation of the stress response and is influenced by early stress exposure. Two CpG sites, cg20813374 and cg00130530, have been identified as potential reporters of early stress. We examined whether FKBP5 methylation was associated with accelerated DNA methylation ageing and indirectly predicted poorer cardiovascular health among both young adult and middle-aged Black Americans. Four hundred and forty-nine young adults, with a mean age of 28.67 and N = 469 middle-age parents and their current partners with a mean age of 57.21, provided self-reports, biometric assessments, and blood draws. Methylation values were obtained using the Illumina Epic Array. Cardiometabolic risk was calculated by summing the standardized log-transformed scores for the body mass index, mean arterial blood pressure, and HbA1c. We also used a more standard index of risk, the Framingham 10-year cardiometabolic risk index, as an alternative measure of cardiometabolic risk. To measure accelerated ageing, four widely used indices of accelerated, DNA methylation-based ageing were used controlling sex, age, other variation in FKBP5, and cell-type. Exposure to community danger was associated with demethylation of FKBP5. FKBP5 methylation was significantly associated with accelerated ageing for both young-adult and middle-aged samples, with significant indirect effects from FKBP5 methylation to cardiometabolic risk through accelerated ageing for both. Early exposure to danger may influence FKBP5 methylation. In turn, FKBP5 methylation may help explain intrinsic accelerated ageing and elevated cardiometabolic risk in adulthood for Black Americans.
C1 [Beach, Steven R. H.] Univ Georgia, Dept Psychol, Athens, GA 30602 USA.
   [Beach, Steven R. H.; Ong, Mei Ling] Univ Georgia, Ctr Family Res, 1095 Coll Stn Rd, Athens, GA 30602 USA.
   [Lei, Man-Kit; Simons, Ronald L.] Univ Georgia, Dept Sociol, Athens, GA 30602 USA.
   [Carter, Sierra E.] Georgia State Univ, Dept Psychol, Univ Plaza, Atlanta, GA 30303 USA.
   [Gibbons, Frederick X.] Univ Connecticut, Dept Psychol Sci, Storrs, CT USA.
   [Philibert, Robert A.] Univ Iowa, Dept Psychiat, Iowa City, IA 52242 USA.
   [Philibert, Robert A.] Behav Diagnost, Coralville, IA USA.
C3 University System of Georgia; University of Georgia; University System
   of Georgia; University of Georgia; University System of Georgia;
   University of Georgia; University System of Georgia; Georgia State
   University; University of Connecticut; University of Iowa
RP Beach, SRH (corresponding author), Univ Georgia, Ctr Family Res, 1095 Coll Stn Rd, Athens, GA 30602 USA.
EM srhbeach@uga.edu
RI Beach, Steven/MBH-1541-2025; Lei, Man/AAM-9616-2020
OI Lei, Man-Kit/0000-0002-7757-6548; Philibert, Robert/0000-0001-7822-4977
FU National Institute of Child Health and Human Development [R01 HD080749];
   National Cancer Institute [R01 CA220254]; National Institute on Aging
   [R01 AG055393]; National Institute on Drug Abuse [P50 DA051361];
   National Cancer Institute [R01CA220254] Funding Source: NIH RePORTER;
   National Institute on Aging [R01AG055393] Funding Source: NIH RePORTER
FX This research was supported by Award Number R01 HD080749 from the
   National Institute of Child Health and Human Development, Award Number
   R01 CA220254 from the National Cancer Institute, Award number R01
   AG055393 from the National Institute on Aging, and Award Number P50
   DA051361 from the National Institute on Drug Abuse.
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NR 74
TC 13
Z9 13
U1 0
U2 4
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1559-2294
EI 1559-2308
J9 EPIGENETICS-US
JI Epigenetics
PD SEP 2
PY 2022
VL 17
IS 9
BP 982
EP 1002
DI 10.1080/15592294.2021.1980688
EA OCT 2021
PG 21
WC Biochemistry & Molecular Biology; Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Genetics & Heredity
GA 4N9PP
UT WOS:000705351400001
PM 34533092
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Lamers, F
   Beekman, ATF
   van Hemert, AM
   Schoevers, RA
   Penninx, BWJH
AF Lamers, F.
   Beekman, A. T. F.
   van Hemert, A. M.
   Schoevers, R. A.
   Penninx, B. W. J. H.
TI Six-year longitudinal course and outcomes of subtypes of depression
SO BRITISH JOURNAL OF PSYCHIATRY
LA English
DT Article
ID POPULATION-BASED SAMPLE; MAJOR DEPRESSION; ATYPICAL FEATURES; DISORDER;
   ANXIETY; NETHERLANDS; COMORBIDITY; VALIDATION; INVENTORY; STABILITY
AB Background
   Clinical and aetiological heterogeneity have impeded our understanding of depression.
   Aims
   To evaluate differences in psychiatric and somatic course between people with depression subtypes that differed clinically (severity) and aetiologically (melancholic v. atypical).
   Method
   Data from baseline, 2-, 4- and 6-year follow-up of The Netherlands Study of Depression and Anxiety were used, and included 600 controls and 648 people with major depressive disorder (subtypes: severe melancholic n=308; severe atypical n=167; moderate n=173, established using latent class analysis).
   Results
   Those with the moderate subtype had a significantly better psychiatric clinical course than the severe melancholic and atypical subtype groups. Suicidal thoughts and anxiety persisted longer in those with the melancholic subtype. The atypical subtype group continued to have the highest body mass index and highest prevalence of metabolic syndrome during follow-up, although differences between groups became less pronounced over time.
   Conclusions
   Course trajectories of depressive subtypes mostly ran parallel to each other, with baseline severity being the most important differentiator in course between groups.
   Copyright and usage
   (C) The Royal College of Psychiatrists 2016.
C1 [Lamers, F.; Beekman, A. T. F.; Penninx, B. W. J. H.] VU Univ Ctr, Dept Psychiat, Amsterdam, Netherlands.
   [Lamers, F.; Beekman, A. T. F.; Penninx, B. W. J. H.] VU Univ Ctr, EMGO Inst Hlth & Care Res, Amsterdam, Netherlands.
   [van Hemert, A. M.] Leiden Univ, Med Ctr, Dept Psychiat, Leiden, Netherlands.
   [Schoevers, R. A.] Univ Groningen, Univ Med Ctr Groningen, Dept Psychiat, Groningen, Netherlands.
C3 Vrije Universiteit Amsterdam; VU UNIVERSITY MEDICAL CENTER; Vrije
   Universiteit Amsterdam; VU UNIVERSITY MEDICAL CENTER; Leiden University;
   Leiden University Medical Center (LUMC); Leiden University - Excl LUMC;
   University of Groningen
RP Lamers, F (corresponding author), GGZ inGeest Vumc, AJ Ernststr 1187, NL-1081 HL Amsterdam, Netherlands.
RI Beekman, Aartjan T./LUZ-6919-2024; Lamers, Femke/G-5161-2012; Penninx,
   Brenda/S-7627-2017
OI Schoevers, Robert A/0000-0003-0760-9866; Lamers,
   Femke/0000-0003-4344-5766
FU NESDA study [10-000-1002]; VU University Medical Center; GGZ inGeest;
   Arkin; Leiden University Medical Center; GGZ Rivierduinen; University
   Medical Center Groningen; Lentis; GGZ Friesland; GGz Drenthe; IQ
   Healthcare; Netherlands Institute for Health Services Research (NIVEL);
   Netherlands Institute of Mental Health and Addiction (Trimbos);
   FP7-Marie Curie CIG [PCIG12-GA-2012-334065]
FX The infrastructure for the NESDA study (www.nesda.nl) is funded through
   the Geestkracht programme of the Netherlands Organisation for Health
   Research and Development (ZonMW, grant number 10-000-1002) and is
   supported by participating universities and mental healthcare
   organisations (VU University Medical Center, GGZ inGeest, Arkin, Leiden
   University Medical Center, GGZ Rivierduinen, University Medical Center
   Groningen, Lentis, GGZ Friesland, GGz Drenthe, IQ Healthcare,
   Netherlands Institute for Health Services Research (NIVEL) and
   Netherlands Institute of Mental Health and Addiction (Trimbos). F.L. is
   supported by a FP7-Marie Curie CIG (PCIG12-GA-2012-334065)
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NR 54
TC 79
Z9 80
U1 0
U2 30
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1250
EI 1472-1465
J9 BRIT J PSYCHIAT
JI Br. J. Psychiatry
PD JAN
PY 2016
VL 208
IS 1
BP 62
EP 68
DI 10.1192/bjp.bp.114.153098
PG 7
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA DB4GB
UT WOS:000368470400014
PM 26294366
OA Bronze
DA 2025-06-11
ER

PT J
AU Wilson, SM
   Sato, AF
AF Wilson, Shana M.
   Sato, Amy F.
TI Stress and Paediatric Obesity: What We Know and Where To Go
SO STRESS AND HEALTH
LA English
DT Article
DE obesity; weight; stress; child
ID BODY-MASS INDEX; METABOLIC SYNDROME; PHYSICAL-ACTIVITY; EATING BEHAVIOR;
   WEIGHT-GAIN; PSYCHOLOGICAL STRESS; PSYCHOSOCIAL STRESS; SOCIAL
   DISADVANTAGE; SALIVARY CORTISOL; DIETARY RESTRAINT
AB Childhood obesity is a public health epidemic and is associated with substantial negative physical and psychosocial health consequences. Stress is thought to be one contributor to the development and maintenance of obesity in children and adolescents, yet the linkage between stress and paediatric obesity is a poorly understood phenomenon. This paper furthers the understanding of stress in the context of paediatric obesity by firstly presenting a focused review of what is known about links between chronic and acute stress and paediatric obesity risk and then synthesizing important areas from the literature. These critical areas of focus include the following: (1) physiological stress reactivity; (2) stress-induced eating; (3) stress and physical activity; (4) parent and family influences; and (5) stress in at-risk populations. This review is geared toward facilitating future research on the stress-obesity connection in youth. Copyright (C) 2013 John Wiley & Sons, Ltd.
C1 [Wilson, Shana M.; Sato, Amy F.] Kent State Univ, Dept Psychol, Kent, OH 44242 USA.
C3 University System of Ohio; Kent State University; Kent State University
   Kent; Kent State University Salem
RP Wilson, SM (corresponding author), Kent State Univ, Dept Psychol, 600 Hilltop Dr, Kent, OH 44242 USA.
EM swilso69@kent.edu
RI Sato, Amy/K-7916-2018
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NR 71
TC 82
Z9 100
U1 1
U2 59
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1532-3005
EI 1532-2998
J9 STRESS HEALTH
JI Stress Health
PD APR
PY 2014
VL 30
IS 2
BP 91
EP 102
DI 10.1002/smi.2501
PG 12
WC Psychology, Applied; Psychiatry; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA AJ2JO
UT WOS:000337482100002
PM 23818395
DA 2025-06-11
ER

PT J
AU Frisman, GH
   Kristenson, M
AF Frisman, Gunilla Hollman
   Kristenson, Margareta
TI Psychosocial status and health related quality of life in relation to
   the metabolic syndrome in a Swedish middle-aged population
SO EUROPEAN JOURNAL OF CARDIOVASCULAR NURSING
LA English
DT Article
DE Metabolic syndrome; Psychosocial; Stress; Life-style; Health related
   quality of life
ID CORONARY-HEART-DISEASE; MYOCARDIAL-INFARCTION; SOCIAL SUPPORT;
   CARDIOVASCULAR-DISEASE; RISK-FACTORS; STRESS; WOMEN; VALIDITY;
   PREVALENCE; MANAGEMENT
AB Background: The Metabolic Syndrome (MS) is a combination of risk factors related to increased risk of cardiovascular disease. Psychosocial factors and stress have been suggested to be important determinants.
   Aim: To analyse how psychosocial factors, perceived stress and health related quality of life are related to MS, and assess if observed associations are dependent of life-style.
   Methods: A cross-sectional study of a random sample of 502 men and 505 women aged 45-69, front southeast Sweden, including fasting blood samples, blood pressure, anthropometrics, self-reported data of life-style, psychosocial status and health related quality of life (SF-36). Linear regression models were adjusted for age and, in a second step, also for life-style.
   Results: Men and women with MS reported lower levels of physical activity, lower scores on physical and social dimensions of SF-36, and women with MS reported stronger effect of social change compared to those without MS (p < 0.05), but we found no differences for mental health or perceived stress. The major part of observed associations was lost after adjustment for effects of life-style.
   Conclusion: Our data speak against a direct effect of social stress on MS via psychological strain but suggest an indirect pathway via a sedentary life-style. (c) 2009 European Society of Cardiology. Published by Elsevier B.V All rights reserved.
C1 [Frisman, Gunilla Hollman] Linkoping Univ, Fac Hlth Sci, Div Nursing Sci, Dept Med & Hlth, S-85185 Linkoping, Sweden.
   [Kristenson, Margareta] Linkoping Univ, Fac Hlth Sci, Div Prevent & Social Med, Dept Med & Hlth, S-85185 Linkoping, Sweden.
C3 Linkoping University; Linkoping University
RP Frisman, GH (corresponding author), Linkoping Univ, Fac Hlth Sci, Div Nursing Sci, Dept Med & Hlth, S-85185 Linkoping, Sweden.
EM Gunilla.Hollman.Frisman@liu.se
FU Swedish Heart and Lung Foundation; Swedish Research Council; Faculty of
   Health Sciences, Linkoping University
FX We thank the Swedish Heart and Lung Foundation the Swedish Research
   Council and the Faculty of Health Sciences, Linkoping University for
   support. We also thank the LSH-study group for supportive discussions,
   especially we thank Elisabeth Wilhelm and John Carstensen for
   statistical advice.
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NR 56
TC 38
Z9 41
U1 0
U2 7
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1474-5151
EI 1873-1953
J9 EUR J CARDIOVASC NUR
JI Eur. J. Cardiovasc. Nurs.
PD AUG
PY 2009
VL 8
IS 3
BP 207
EP 215
DI 10.1016/j.ejcnurse.2009.01.004
PG 9
WC Cardiac & Cardiovascular Systems; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Cardiovascular System & Cardiology; Nursing
GA 483HB
UT WOS:000268952700008
PM 19246246
OA Bronze
DA 2025-06-11
ER

PT J
AU Cheon, SY
AF Cheon, So Yeong
TI Impaired Cholesterol Metabolism, Neurons, and Neuropsychiatric Disorders
SO EXPERIMENTAL NEUROBIOLOGY
LA English
DT Article
DE Cholesterol; Major depressive disorders; Anxiety disorders; Neurons;
   Synapse; Neurotransmission
ID GENERALIZED ANXIETY DISORDER; SERUM-CHOLESTEROL; BRAIN CHOLESTEROL;
   HYPERCHOLESTEROLEMIA; ASSOCIATION; DEPRESSION; MECHANISMS; MICE;
   DYSREGULATION; ACCUMULATION
AB Cholesterol metabolism plays an essential role in cellular functions (including as a component of the plasma membrane, as an energy source, and in hormone production) under normal conditions. Dysregulated cholesterol metabolism causes a wide spectrum of pathological conditions, leading to neuropsychiatric disorders, such as anxiety and depression. In addition, patients with neuropsychiatric disorders also have impaired cholesterol metabolism. Therefore, metabolic disturbances are closely associated with the neuropsychiatric disorders. Although immune disturbance, neuro-inflammation, a dysregulated neurotransmitter system, and oxidative stress have been suggested as pathophysiology of neuropsychiatric disorders, dysregulation of cholesterol metabolism is also found in patients with psychiatric diseases. As expected, patients with mental illness appear to be at risk of metabolic disorders, including metabolic syndrome, in which cholesterol influences altered neuronal homeostasis, such as neuronal cell toxicity, neuronal cell death, and neuronal structures and functions, including synaptogenesis, neurogenesis, axonogenesis, and action potential. Therefore, reversing impaired or abnormal cholesterol metabolism may help restore neuronal injury found in mental illness. This review is aimed to discuss the links between cholesterol metabolism impairment and neuropsychiatric disorders and provides insights into neuronal dysfunction due to abnormal cholesterol metabolism in neuropsychiatric disorders.
C1 [Cheon, So Yeong] Konkuk Univ, Coll Biomed & Hlth Sci, Dept Biotechnol, Chungju 27478, South Korea.
   [Cheon, So Yeong] Konkuk Univ, Res Inst Biomed & Hlth Sci, Chungju 27478, South Korea.
C3 Konkuk University; Konkuk University
RP Cheon, SY (corresponding author), Konkuk Univ, Coll Biomed & Hlth Sci, Dept Biotechnol, Chungju 27478, South Korea.; Cheon, SY (corresponding author), Konkuk Univ, Res Inst Biomed & Hlth Sci, Chungju 27478, South Korea.
EM sycheon14@kku.ac.kr
RI Cheon, So Yeong/AER-6628-2022
OI Cheon, So Yeong/0000-0001-7015-4898
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NR 106
TC 24
Z9 26
U1 0
U2 9
PU KOREAN SOC BRAIN & NEURAL SCIENCE, KOREAN SOC NEURODEGENERATIVE DISEASE
PI SEOUL
PA EXPERIMENTAL NEUROBIOLOGY,  SEOUL NATL UNIV, RM 410, BLDG 152-1, SEOUL,
   151-742, SOUTH KOREA
SN 1226-2560
EI 2093-8144
J9 EXP NEUROBIOL
JI Exp. Neurobiol.
PD APR
PY 2023
VL 32
IS 2
BP 57
EP 67
DI 10.5607/en23010
PG 11
WC Medicine, Research & Experimental; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Neurosciences & Neurology
GA H4XW2
UT WOS:000996019400001
PM 37164646
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Jones, A
   Godfrey, KM
   Wood, P
   Osmond, C
   Goulden, P
   Phillips, DIW
AF Jones, A
   Godfrey, KM
   Wood, P
   Osmond, C
   Goulden, P
   Phillips, DIW
TI Fetal growth and the adrenocortical response to psychological stress
SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Article
ID BIRTH-WEIGHT; CORTISOL CONCENTRATIONS; LIFE
AB Context: Experimental studies in animals show that adverse prenatal environments lead to lifelong alterations in the activity of the hypothalamic- pituitary- adrenal axis, which mediates the stress response through secretion of glucocorticoid hormones. The extent to which such prenatal hypothalamic- pituitary- adrenal axis adaptations occur in humans is unknown.
   Objective: The objective of the study was to determine whether smaller but otherwise healthy term babies are more likely to demonstrate increased glucocorticoid responses to psychological stress in childhood.
   Design and Participants: This was a cross- sectional study of 68 boys and 72 girls ( aged 7 - 9 yr) who have been followed up since 12 wk gestation when their mothers took part in a study of healthy children born in Southampton, United Kingdom.
   Main Outcome Measure: Salivary cortisol responses to psychological stress were measured.
   Results: In boys, birth weight was inversely related to salivary cortisol responses to stress ( r = - 0.56, P < 0.001) but not morning cortisol levels, whereas in girls, morning peak cortisol was inversely related to birth weight ( r = - 0.36, P < 0.05). These associations were independent of gestational age and potential confounding factors including obesity, social class, and educational achievement.
   Conclusions: This study suggests that processes occurring during fetal life, resulting in smaller newborns, have a lasting effect on adrenocortical responses to stress in boys and on basal adrenocortical activity in girls. Given the known associations between small alterations in adrenocortical activity and features of the metabolic syndrome such as raised blood pressure and glucose intolerance, these effects warrant further investigation of their potential impact on the future health of prepubertal children.
C1 Southampton Gen Hosp, MRC, Southampton SO16 6YD, Hants, England.
C3 University of Southampton
RP Southampton Gen Hosp, MRC, Tremona Rd, Southampton SO16 6YD, Hants, England.
EM aj@mrc.soton.ac.uk
OI Osmond, Clive/0000-0002-9054-4655; Godfrey, Keith/0000-0002-4643-0618;
   Goulden, Peter/0000-0001-6145-3589
FU Medical Research Council [MC_U147585827, MC_UP_A620_1014] Funding
   Source: Medline; NICHD NIH HHS [1 R01 HD41107-01] Funding Source:
   Medline; MRC [MC_U147585827] Funding Source: UKRI
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NR 15
TC 132
Z9 140
U1 0
U2 13
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0021-972X
EI 1945-7197
J9 J CLIN ENDOCR METAB
JI J. Clin. Endocrinol. Metab.
PD MAY
PY 2006
VL 91
IS 5
BP 1868
EP 1871
DI 10.1210/jc.2005-2077
PG 4
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 039TL
UT WOS:000237330000038
PM 16464950
DA 2025-06-11
ER

PT J
AU Fond, G
   Boyer, L
   Andrianarisoa, M
   Godin, O
   Bulzacka, E
   Berna, F
   Brunel, L
   Coulon, N
   Aouizerate, B
   Capdevielle, D
   Chereau, I
   D'amato, T
   Denizot, H
   Dubertret, C
   Dubreucq, J
   Faget, C
   Leignier, S
   Mallet, J
   Misdrahi, D
   Rey, R
   Lancon, C
   Passerieux, C
   Schandrin, A
   Urbach, M
   Vidailhet, P
   Leboyer, M
   Schurhoff, F
   Llorca, PM
AF Fond, Guillaume
   Boyer, Laurent
   Andrianarisoa, Meja
   Godin, Ophelia
   Bulzacka, Ewa
   Berna, Fabrice
   Brunel, Lore
   Coulon, Nathalie
   Aouizerate, Bruno
   Capdevielle, Delphine
   Chereau, Isabelle
   D'amato, Thierry
   Denizot, Helene
   Dubertret, Caroline
   Dubreucq, Julien
   Faget, Catherine
   Leignier, Sylvain
   Mallet, Jasmina
   Misdrahi, David
   Rey, Romain
   Lancon, Christophe
   Passerieux, Christine
   Schandrin, Aurelie
   Urbach, Mathieu
   Vidailhet, Pierre
   Leboyer, Marion
   Schurhoff, Franck
   Llorca, Pierre-Michel
CA FACE-SZ FondaMental Acad Ctr Exper
TI Self-reported pain in patients with schizophrenia. Results from the
   national first-step FACE-SZ cohort
SO PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
LA English
DT Article
DE Physical pain; Schizophrenia; Headache; Depression; Anxiety; Childhood
   trauma
ID MAJOR DEPRESSIVE DISORDER; LARGE-SCALE METAANALYSIS; A-META-ANALYSIS;
   BIPOLAR DISORDER; PSYCHOLOGICAL-FACTORS; METABOLIC SYNDROME;
   MENTAL-HEALTH; PEOPLE; ANXIETY; PREVALENCE
AB Introduction: Little is known about perception of physical pain in schizophrenia (SZ). Some studies have suggested that patients with SZ may have an increased pain threshold, while others have suggested that patients with SZ may suffer from undetected and untreated high physical pain levels. The objectives of this study were (i) to investigate the prevalence of self-reported physical pain in stabilized SZ subjects, and (ii) to determine whether physical pain was associated with psychiatric characteristics and somatic comorbidities (iii) to determine whether antidepressants and benzodiazepine administration were associated with lower self-reported pain.
   Method: 468 community-dwelling stable SZ subjects (73% men, mean aged 32 years) were recruited in the Schizophrenia Expert Center national network. Patients with moderate to extreme pain, assessed with the EQ5D-5L questionnaire, were classified as belonging to the "pain group".
   Results: 104 (22.2%) reported moderate to extreme pain levels. In multivariate analysis, pain has been associated with headache (OR= 2.63 [1.04-6.63], p= 0.04), higher anxiety (OR= 1.61 [1.18-2.21], p= 0.003), higher current depressive symptoms (OR= 1.09 [1.01-1.17], p= 0.03), history of childhood trauma (1.03 [1.01-1.06], p= 0.01) and older age (OR= 1.04 [1.01-1.07], p= 0.03), independently of current psychotic severity, sociodemographic variables, antipsychotic, antidepressant and benzodiazepine treatments. No association with addictive behaviors or illness characteristics has been found.
   Conclusion: The present findings suggest that community-dwelling SZ outpatients report a high rate of self-reported physical pain, associated with headache, depression and anxiety and history of childhood trauma. Physical pain should be systematically assessed and specifically treated, when needed, in patients with SZ.
C1 [Fond, Guillaume; Boyer, Laurent; Andrianarisoa, Meja; Godin, Ophelia; Bulzacka, Ewa; Berna, Fabrice; Brunel, Lore; Coulon, Nathalie; Aouizerate, Bruno; Capdevielle, Delphine; Chereau, Isabelle; D'amato, Thierry; Denizot, Helene; Dubertret, Caroline; Dubreucq, Julien; Faget, Catherine; Leignier, Sylvain; Mallet, Jasmina; Misdrahi, David; Rey, Romain; Lancon, Christophe; Passerieux, Christine; Schandrin, Aurelie; Urbach, Mathieu; Vidailhet, Pierre; Leboyer, Marion; Schurhoff, Franck; Llorca, Pierre-Michel] Fdn FondaMental, Creteil, France.
   [Andrianarisoa, Meja; Bulzacka, Ewa; Brunel, Lore; Coulon, Nathalie; Leboyer, Marion; Schurhoff, Franck] INSERM U955, Translat Psychiat Team, Creteil, France.
   [Fond, Guillaume; Boyer, Laurent] Aix Marseille Univ, Sch MED, CEReSS Hlth Serv Res & Qual Life Ctr, EA 3279, La Timone Med Campus,27 Blvd Jean Moulin, F-13005 Marseille, France.
   [Aouizerate, Bruno; Misdrahi, David] Univ Bordeaux, Ctr Hosp Charles Perrens, F-33076 Bordeaux, France.
   [Berna, Fabrice; Vidailhet, Pierre] Univ Strasbourg, Hop Univ Strasbourg, INSERM U1114, Federat Med Translat Strasbourg, Strasbourg, France.
   [Capdevielle, Delphine; Schandrin, Aurelie] Univ Montpellier I, Serv Univ Psychiat Adulte, Inserm, CHRU Montpellier,Hop Colombiere, F-1061 Montpellier, France.
   [Chereau, Isabelle; Denizot, Helene; Llorca, Pierre-Michel] Univ Auvergne, Fac Med, EA 7280, CMP B,CHU, BP 69, F-63003 Clermont Ferrand 1, France.
   [D'amato, Thierry; Rey, Romain] Univ Claude Bernard Lyon 1, Ctr Hosp Le Vinatier, Pole Est, BP 300 39-95 Bd Pinel, F-69678 Bron, France.
   [Dubertret, Caroline; Mallet, Jasmina] Univ Paris Diderot, Louis Mourier Hosp, Sorbonne Paris Cite, Dept Psychiat,AP HP,Inserm U894,Fac Med, Colombes, France.
   [Dubreucq, Julien; Leignier, Sylvain] CH Alpes Isere, Ctr Referent Rehabil Psychosociale, Grenoble, France.
   [Faget, Catherine; Lancon, Christophe] Pole Univ Psychiat, AP HM, Marseille, France.
   [Passerieux, Christine; Urbach, Mathieu] Univ Versailles St Quentin Yvelines, Ctr Hosp Versailles, Serv Psychiat Adulte, UFR Sci Sante Simone Veil, Versailles, France.
   [Aouizerate, Bruno] INSERM, Neuroctr Magendie Physiopathol Plasticite Neurona, U862, F-33000 Bordeaux, France.
   [Misdrahi, David] CNRS, UMR 5287, INCIA, Paris, France.
   [Godin, Ophelia] UPMC Univ Paris 06, Sorbonne Univ, UMR S 1136, Inst Pierre Louis Epidemiol & Sante Publ, F-75013 Paris, France.
   [Godin, Ophelia] INSERM, UMR S 1136, Inst Pierre Louis Epidemiol & Sante Publ, F-75013 Paris, France.
   [Andrianarisoa, Meja; Bulzacka, Ewa; Brunel, Lore; Coulon, Nathalie; Leboyer, Marion; Schurhoff, Franck] Paris Est Univ, Hop Univ H Mondor, DHU Pe PSY, Pole Psychiat, Creteil, France.
C3 Institut National de la Sante et de la Recherche Medicale (Inserm);
   Universite Paris-Est-Creteil-Val-de-Marne (UPEC); Aix-Marseille
   Universite; Universite de Bordeaux; CHU Strasbourg; Institut National de
   la Sante et de la Recherche Medicale (Inserm); Universites de Strasbourg
   Etablissements Associes; Universite de Strasbourg; Institut National de
   la Sante et de la Recherche Medicale (Inserm); Universite de
   Montpellier; CHU de Montpellier; Universite Clermont Auvergne (UCA); CHU
   Clermont Ferrand; Universite Claude Bernard Lyon 1; Universite Paris
   Cite; Assistance Publique Hopitaux Paris (APHP); Hopital Universitaire
   Louis-Mourier - APHP; Institut National de la Sante et de la Recherche
   Medicale (Inserm); Aix-Marseille Universite; Assistance
   Publique-Hopitaux de Marseille; Centre Hospitalier de Versailles;
   Universite Paris Saclay; Universite de Bordeaux; Institut National de la
   Sante et de la Recherche Medicale (Inserm); Centre National de la
   Recherche Scientifique (CNRS); CNRS - National Institute for Biology
   (INSB); Institut National de la Sante et de la Recherche Medicale
   (Inserm); Sorbonne Universite; Sorbonne Universite; Institut National de
   la Sante et de la Recherche Medicale (Inserm); Assistance Publique
   Hopitaux Paris (APHP); Universite Paris-Est-Creteil-Val-de-Marne (UPEC);
   Hopital Universitaire Henri-Mondor - APHP
RP Fond, G (corresponding author), Aix Marseille Univ, Fac Med Sect Timone, EA 3279, CEReSS Ctr Etud & Rech Serv Sante & Qualit Vie, 27 Blvd Jean Moulin, F-13005 Marseille, France.
EM guillaume.fond@ap-hm.fr
RI Boyer, Laurent/E-5728-2016; Mallet, Jasmina/GNP-7160-2022; TESSIER,
   Arnaud/A-4022-2017; Schandrin, Aurélie/ISV-4608-2023; Capdevielle,
   Delphine/HTO-4229-2023; Berna, Fabrice/J-2701-2019; COULON,
   Nathalie/HLW-3075-2023; Leboyer, Marion/AAW-3648-2021; FOND,
   Guillaume/D-7646-2011
OI LEBOYER, Marion/0000-0001-5473-3697; D'Amato,
   Thierry/0000-0001-8983-0315; FOND, Guillaume/0000-0003-3249-2030;
   Aouizerate, Bruno/0000-0002-7092-7747; Capdevielle,
   Delphine/0000-0002-7146-8554; Misdrahi, David/0000-0003-1146-3206; REY,
   Romain/0000-0002-4603-3575; dubreucq, julien/0000-0003-4079-4194;
   COULON, Nathalie/0000-0001-7765-1117
FU AP-HM (Assistance Publique des Hopitaux de Marseille); Fondation
   FondaMental (RTRS Sante Mentale); Investissements d'Avenir program
   [ANR-11-IDEX-0004-02, ANR-10-COHO-10-01]; INSERM (Institut National de
   la Sante et de la Recherche Medicale)
FX This work was funded by AP-HM (Assistance Publique des Hopitaux de
   Marseille), Fondation FondaMental (RTRS Sante Mentale), by the
   Investissements d'Avenir program managed by the ANR under reference
   ANR-11-IDEX-0004-02 and ANR-10-COHO-10-01, and by INSERM (Institut
   National de la Sante et de la Recherche Medicale). We express all our
   thanks to the nurses, and to the patients who were included in the
   present study.
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NR 53
TC 14
Z9 14
U1 0
U2 6
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0278-5846
EI 1878-4216
J9 PROG NEURO-PSYCHOPH
JI Prog. Neuro-Psychopharmacol. Biol. Psychiatry
PD JUL 13
PY 2018
VL 85
BP 62
EP 68
DI 10.1016/j.pnpbp.2018.04.007
PG 7
WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA GG7FW
UT WOS:000432864900009
PM 29678770
DA 2025-06-11
ER

PT J
AU Del Rio, D
   Morales, L
   Ruiz-Gayo, M
   Del Olmo, N
AF Del Rio, Danila
   Morales, Lidia
   Ruiz-Gayo, Mariano
   Del Olmo, Nuria
TI Effect of high-fat diets on mood and learning performance in adolescent
   mice
SO BEHAVIOURAL BRAIN RESEARCH
LA English
DT Article
DE High-fat diet; Learning; Memory; Fluoxetine; Diazepam; Depression
ID HIPPOCAMPAL SYNAPTIC PLASTICITY; DEPRESSIVE-LIKE BEHAVIOR; BODY-MASS
   INDEX; COGNITIVE FUNCTION; METABOLIC SYNDROME; IMPAIRMENT; OBESITY;
   BRAIN; ANXIETY; STRESS
AB Recent studies point to dietary factors as important effectors in the brain and epidemiological studies suggest a direct relationship between mood and anxiety disorders, cognitive impairment and obesity. Nevertheless the link between the consumption of high-fat diets (HFD) and emotional disorders still remains unclear. This issue is of particular interest during adolescence, which is an important period for shaping learning and memory acquisition that can be particularly sensitive to the detrimental effects of HFD. Otherwise, major depressive disorder and anxiety crisis often emerge in adolescence. In the current study we have characterized in adolescent mice i) the onset of HFD-induced memory impairment using the novel location recognition (NLR) paradigm, and ii) the effect of HFD on depression- and anxiety-related behaviors by using the forced swimming and the elevated plus maze tests, respectively. Here we report that memory impairments induced by HFD were already perceptible after 4-weeks HFD whereas HFD induced already antidepressant-like effects after 48-h, that remained after long-term treatment (8 weeks). No effects in anxiety were found. These data indicate that the antidepressant-like effect of HFD is independent of memory deficits as it was already present after 48-h HFD, while no effects in memory were still observed at this time. (C) 2016 Elsevier B.V. All rights reserved.
C1 [Del Rio, Danila; Morales, Lidia; Ruiz-Gayo, Mariano; Del Olmo, Nuria] Univ CEU San Pablo, Fac Farm, Dept Ciencias Farmaceut & Salud, Campus Monteprincipe, Madrid 28668, Spain.
C3 San Pablo CEU University
RP Del Olmo, N (corresponding author), Univ CEU San Pablo, Fac Farm, Dept Ciencias Farmaceut & Salud, Campus Monteprincipe, Madrid 28668, Spain.
EM nolmo@ceu.es
RI Ruiz-Gayo, Mariano/H-3720-2015; Del Olmo, Nuria/ABG-2171-2020
OI Del Olmo, Nuria/0000-0001-5611-4152
FU Ministerio de Economia [SAF2011-25300, BFU2012-35353]; Fundacion
   Universitaria San Pablo-CEU
FX This work was supported by the Ministerio de Economia (SAF2011-25300 and
   BFU2012-35353) and the Fundacion Universitaria San Pablo-CEU.
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NR 41
TC 36
Z9 39
U1 0
U2 43
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0166-4328
EI 1872-7549
J9 BEHAV BRAIN RES
JI Behav. Brain Res.
PD SEP 15
PY 2016
VL 311
BP 167
EP 172
DI 10.1016/j.bbr.2016.04.052
PG 6
WC Behavioral Sciences; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Behavioral Sciences; Neurosciences & Neurology
GA DS1XJ
UT WOS:000380418200018
PM 27212119
DA 2025-06-11
ER

PT J
AU Pompili, M
   Giordano, G
   Luciano, M
   Lamis, DA
   Del Vecchio, V
   Serafini, G
   Sampogna, G
   Erbuto, D
   Falkai, P
   Fiorillo, A
AF Pompili, Maurizio
   Giordano, Gloria
   Luciano, Mario
   Lamis, Dorian A.
   Del Vecchio, Valeria
   Serafini, Gianluca
   Sampogna, Gaia
   Erbuto, Denise
   Falkai, Peter
   Fiorillo, Andrea
TI Unmet Needs in Schizophrenia
SO CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
LA English
DT Review
DE Cognitive; emotional; psychosocial; psychiatric disorder; symptoms;
   schizophrenia
ID QUALITY-OF-LIFE; COGNITIVE REMEDIATION THERAPY; ATYPICAL
   ANTIPSYCHOTIC-DRUGS; REVERSES MK-801-INDUCED IMPAIRMENT; DOUBLE-BLIND;
   METABOLIC SYNDROME; NEGATIVE SYMPTOMS; ENHANCEMENT THERAPY;
   WORKING-MEMORY; 2ND-GENERATION ANTIPSYCHOTICS
AB Background: Schizophrenia is a complex psychiatric disorder that represents a challenge for all clinicians. Although treatment must address both positive and negative symptoms, several authors have reported the importance of managing unmet needs among patients with schizophrenia. Unmet needs in schizophrenia include difficulties at various clinical, psychosocial, relational, economic, and occupational levels. An important unmet need is represented by insight into the illness that is associated with treatment adherence and compliance with medical prescriptions.
   Conclusion: In order to improve our understanding and management of schizophrenia, it is critically important to address the complexity of needs among patients with schizophrenia.
C1 [Pompili, Maurizio; Giordano, Gloria; Erbuto, Denise] Sapienza Univ Rome, St Andrea Hosp, Suicide Prevent Ctr, Dept Neurosci Mental Hlth & Sensory Organs, Rome, Italy.
   [Luciano, Mario; Del Vecchio, Valeria; Sampogna, Gaia; Fiorillo, Andrea] Univ Campania L Vanvitelli, Dept Psychiat, Naples, Italy.
   [Lamis, Dorian A.] Emory Univ, Sch Med, Dept Psychiat & Behav Sci, Atlanta, GA USA.
   [Serafini, Gianluca] Univ Genoa, Sect Psychiat, Dept Neurosci Rehabil Ophthalmol Genet Maternal &, Genoa, Italy.
   [Falkai, Peter] Ludwig Maximilians Univ Munchen, Dept Psychiat & Psychotherapy, Munich, Germany.
C3 Sapienza University Rome; Azienda Ospedaliera Sant'Andrea; Universita
   della Campania Vanvitelli; Emory University; University of Genoa;
   University of Munich
RP Pompili, M (corresponding author), Sapienza Univ Rome, St Andrea Hosp, Dept Neurosci Mental Hlth & Sensory Organs, Via Grottarossa 1035, I-00189 Rome, Italy.
EM maurizio.pompili@uniroma1.it
RI Pompili, Maurizio/AAC-1011-2019; Lamis, Dorian/AAM-3651-2020; Fiorillo,
   Andrea/AHH-4551-2022; Falkai, Peter/E-3273-2017; Sampogna,
   Gaia/AHH-4608-2022; Serafini, Gianluca/K-6603-2016
OI Fiorillo, Andrea/0000-0002-6926-0762; Falkai, Peter/0000-0003-2873-8667;
   Lamis, Dorian/0000-0001-5405-0239; Luciano, Mario/0000-0002-4338-1371;
   Sampogna, Gaia/0000-0002-9547-2793; Serafini,
   Gianluca/0000-0002-6631-856X
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NR 162
TC 22
Z9 22
U1 0
U2 7
PU BENTHAM SCIENCE PUBL
PI BUSUM
PA PO BOX 294, BUSUM, 1400 AG, NETHERLANDS
SN 1871-5273
EI 1996-3181
J9 CNS NEUROL DISORD-DR
JI CNS Neurol. Disord.-Drug Targets
PY 2017
VL 16
IS 8
BP 870
EP 884
DI 10.2174/1871527316666170803143927
PG 15
WC Neurosciences; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Pharmacology & Pharmacy
GA FT1HQ
UT WOS:000422886500003
PM 28782490
DA 2025-06-11
ER

PT J
AU Chedraui, P
   Pérez-López, FR
   Hidalgo, L
   Villacreses, D
   Domínguez, A
   Escobar, GS
   Genazzani, AR
   Simoncini, T
AF Chedraui, Peter
   Perez-Lopez, Faustino R.
   Hidalgo, Luis
   Villacreses, Diego
   Dominguez, Andrea
   Escobar, Gustavo S.
   Genazzani, Andrea R.
   Simoncini, Tommaso
CA Omega Women's Hlth Project
TI Evaluation of the presence and severity of menopausal symptoms among
   postmenopausal women screened for the metabolic syndrome
SO GYNECOLOGICAL ENDOCRINOLOGY
LA English
DT Article
DE Hospital anxiety and depression scale; menopausal symptoms; menopause
   rating scale; metabolic syndrome; postmenopause
ID MIDDLE-AGED WOMEN; TREATMENT PANEL-III; QUALITY-OF-LIFE; RISK-FACTORS;
   DEPRESSIVE SYMPTOMS; VASOMOTOR SYMPTOMS; HEALTH; MIDLIFE; PAIN;
   INFLAMMATION
AB Background: The prevalence of the metabolic syndrome (METS) increases after the menopause. Reports indicate that the METS and its components, especially obesity, enhance the intensity of menopausal symptoms.
   Objective: Assess the frequency and severity of menopausal symptoms in postmenopausal women. Factors related to the symptom severity were also analyzed including depressive and metabolic status.
   Methods: A total of 204 natural postmenopausal women (40-65 years) participating in a METS screening program were asked to fill out the Menopause Rating Scale (MRS), the Hospital Anxiety and Depression Scale (HADS), and a general socio-demographic questionnaire containing personal and partner data. Criteria of the American Heart Association were used to define the METS.
   Results: Median age of the whole sample was 56 years. A 52.9% presented the METS, with 37.3% presenting hyperglycemia, 51.5% hypertension, 58.3% abdominal obesity, 45.6% high triglyceride and 56.4% low HDL-C levels. Total and subscale MRS scores did not differ in accordance to the presence or not of the METS. The three top prevalent menopausal symptoms were muscle and joint problems (87.2%), physical and mental exhaustion (72%) and depressive mood (64.7%). A 19.6% of women presented total MRS scores above 16 defined as severe. Multivariate linear regression analysis determined that anxiety (higher HADS anxiety subscale scores) was significantly and positively correlated with all components of the MRS (Total and subscale scores). Higher total MRS scores correlated positively with abdominal perimeter and higher parity. Somatic scores correlated inversely with female education and positively with psychotropic drug use; and psychological MRS scores positively correlated depressed mood (higher HADS depressive subscale scores) and abdominal perimeter.
   Conclusion: In this postmenopausal sample, severity of menopausal symptoms correlated to abdominal obesity, mood and other personal aspects.
C1 [Chedraui, Peter; Hidalgo, Luis; Villacreses, Diego; Dominguez, Andrea; Escobar, Gustavo S.] Univ Catolica Santiago Guayaquil, Fac Ciencias Med, Inst Biomed, Res Area Womens Hlth, Guayaquil, Ecuador.
   [Perez-Lopez, Faustino R.] Univ Zaragoza, Lozano Blesa Univ Hosp, Fac Med, Dept Obstet & Gynecol, Zaragoza, Spain.
   [Hidalgo, Luis] Enrique C Sotomayor Obstet & Gynecol Hosp, Guayaquil, Ecuador.
   [Genazzani, Andrea R.; Simoncini, Tommaso] Univ Pisa, Dept Clin & Expt Med, Div Obstet & Gynecol, Pisa, Italy.
C3 Lozano Blesa University Clinical Hospital; University of Zaragoza;
   University of Pisa
RP Chedraui, P (corresponding author), Univ Catolica Santiago Guayaquil, Fac Ciencias Med, Inst Biomed, Res Area Womens Hlth, POB 09-01-4671, Guayaquil, Ecuador.
EM peter.chedraui@cu.ucsg.edu.ec
RI Blümel, Juan Enrique/JUV-6950-2023; Simoncini, Tommaso/AAC-1879-2019
OI Perez-Lopez, Faustino R./0000-0002-2801-416X; Simoncini,
   Tommaso/0000-0002-2971-0079; Escobar Valdivieso, Gustavo
   Saul/0000-0003-1690-3936
FU Universidad Catolica de Santiago de Guayaquil, Ecuador by the Sistema de
   Investigacion y Desarrollo [SIU-3373-2011]
FX This research was supported by the Universidad Catolica de Santiago de
   Guayaquil, Ecuador, through grant No. SIU-3373-2011 (The Omega Women's
   Health Project 2011) provided by the Sistema de Investigacion y
   Desarrollo.
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NR 43
TC 9
Z9 9
U1 0
U2 6
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0951-3590
EI 1473-0766
J9 GYNECOL ENDOCRINOL
JI Gynecol. Endocrinol.
PD DEC
PY 2014
VL 30
IS 12
BP 918
EP 924
DI 10.3109/09513590.2014.971236
PG 7
WC Endocrinology & Metabolism; Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Obstetrics & Gynecology
GA AT8YA
UT WOS:000345213700015
PM 25347000
DA 2025-06-11
ER

PT J
AU Balasubramanyam, A
   Rao, S
   Misra, R
   Sekhar, RV
   Ballantyne, CM
AF Balasubramanyam, Ajay
   Rao, Shaun
   Misra, Ranjita
   Sekhar, Rajagopal V.
   Ballantyne, Christie M.
TI Prevalence of Metabolic Syndrome and Associated Risk Factors in Asian
   Indians
SO JOURNAL OF IMMIGRANT AND MINORITY HEALTH
LA English
DT Article
DE Metabolic syndrome; Cardiovascular risk; Ethnicity; Lifestyle; Health
   perception
ID CORONARY-HEART-DISEASE; C-REACTIVE PROTEIN; SOUTH ASIANS;
   CARDIOVASCULAR-DISEASE; MYOCARDIAL-INFARCTION; INSULIN-RESISTANCE;
   ETHNIC-DIFFERENCES; EUROPEAN ORIGIN; POPULATION; HEALTH
AB Objective This study examined the association between metabolic syndrome, lifestyle behaviors, and perception and knowledge of current health and cardiovascular disease (CVD) among Asian Indians in the US. Method The sample comprised of 143 adult Asian Indians recruited through health fairs for survey and bioclinical measures. Results The prevalence of metabolic syndrome was 32%, much higher than other ethnic groups, did not vary by gender but increased with age. Respondents had high physical inactivity and poor knowledge of CVD risk factors. Dietary behavior, age, number of years lived in the US, self-rated physical and mental health and BMI were significant predictors and explained 40.1% of variance in metabolic syndrome score. Poorer physical health status had the greatest predictive influence on metabolic syndrome. Conclusion Asian Indians are a high risk group for CVD.
C1 [Misra, Ranjita] Texas A&M Univ, Dept Hlth & Kinesiol, College Stn, TX 77843 USA.
   [Balasubramanyam, Ajay] Emory Univ, Atlanta, GA 30322 USA.
   [Sekhar, Rajagopal V.] Baylor Coll Med, Div Endocrinol Diabet & Metab, Houston, TX 77030 USA.
   [Ballantyne, Christie M.] Methodist DeBakey Heart Ctr, Ctr Cardiovasc Dis Prevent, Houston, TX 77030 USA.
C3 Texas A&M University System; Texas A&M University College Station; Emory
   University; Baylor College of Medicine; Houston Methodist
RP Misra, R (corresponding author), Texas A&M Univ, Dept Hlth & Kinesiol, 158 V Read Bldg,4243 TAMU, College Stn, TX 77843 USA.
EM abalasu@learnlink.emory.edu; raoshaun1@neo.tamu.edu;
   misra@hlkn.tamu.edu; rsekhar@bcm.edu; cmb@bcm.tmc.edu
RI Ballantyne, Christie/A-6599-2008
OI Ballantyne, Christie/0000-0002-6432-1730; Misra,
   Ranjita/0000-0001-7314-0184
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NR 44
TC 29
Z9 33
U1 0
U2 7
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1557-1912
EI 1557-1920
J9 J IMMIGR MINOR HEALT
JI J. Immigr. Minor. Health
PD AUG
PY 2008
VL 10
IS 4
BP 313
EP 323
DI 10.1007/s10903-007-9092-4
PG 11
WC Public, Environmental & Occupational Health
WE Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA V13DV
UT WOS:000207648400003
PM 18026838
DA 2025-06-11
ER

PT J
AU Murdock, KW
   LeRoy, AS
   Fagundes, CP
AF Murdock, Kyle W.
   LeRoy, Angie S.
   Fagundes, Christopher P.
TI Inhibition is associated with metabolic syndrome and depression through
   inflammation
SO STRESS AND HEALTH
LA English
DT Article
DE depression; inflammation; inhibition; metabolic syndrome
ID COGNITION; BRAIN; TELEPHONE; ATTENTION; SYMPTOMS; SYSTEM; HEALTH; IMPACT
AB Inhibition is the ability to stop one's self from responding, or paying attention, to tempting/distracting stimuli or thoughts. Those with poor inhibition are at greater risk of depression and a variety of diseases of older adulthood than those with better inhibition. Inflammation may be a mechanism underlying these links. A total of 840 participants from the Midlife in the United States study completed a neuropsychological measure of inhibition, a self-report measure of depressive symptoms, and a blood draw. Results indicated that poor inhibition was associated with high interleukin-6 (IL-6). Inhibition was indirectly associated with metabolic syndrome incidence and depressive symptoms through IL-6. Findings suggest that IL-6 may be a mechanism linking inhibition with metabolic syndrome and depression.
C1 [Murdock, Kyle W.; LeRoy, Angie S.; Fagundes, Christopher P.] Rice Univ, Dept Psychol, Houston, TX 77251 USA.
   [Murdock, Kyle W.] Penn State Univ, Dept Biobehav Hlth, 219 Biobehav Hlth Bldg, University Pk, PA 16802 USA.
   [LeRoy, Angie S.] Univ Houston, Dept Psychol, Houston, TX USA.
   [Fagundes, Christopher P.] Univ Texas MD Anderson Canc Ctr, Dept Behav Sci, Houston, TX 77030 USA.
   [Fagundes, Christopher P.] Baylor Coll Med, Dept Psychiat, Houston, TX 77030 USA.
C3 Rice University; Pennsylvania Commonwealth System of Higher Education
   (PCSHE); Pennsylvania State University; Pennsylvania State University -
   University Park; Penn State Behrend; University of Houston System;
   University of Houston; University of Texas System; UTMD Anderson Cancer
   Center; Baylor College of Medicine
RP Murdock, KW (corresponding author), Penn State Univ, Dept Biobehav Hlth, 219 Biobehav Hlth Bldg, University Pk, PA 16802 USA.
EM kyle.murdock@psu.edu
RI LeRoy, Angie/JZE-5550-2024
OI LeRoy, Angie/0000-0003-2143-7634
FU NIA NIH HHS [P01 AG020166, U19 AG051426] Funding Source: Medline
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NR 24
TC 2
Z9 2
U1 0
U2 9
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1532-3005
EI 1532-2998
J9 STRESS HEALTH
JI Stress Health
PD AUG
PY 2018
VL 34
IS 3
BP 457
EP 461
DI 10.1002/smi.2808
PG 5
WC Psychology, Applied; Psychiatry; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA GP9QK
UT WOS:000441251300013
PM 29602200
DA 2025-06-11
ER

PT J
AU Mörkl, S
   Stell, L
   Buhai, DV
   Schweinzer, M
   Wagner-Skacel, J
   Vajda, C
   Lackner, S
   Bengesser, SA
   Lahousen, T
   Painold, A
   Oberascher, A
   Tatschl, JM
   Fellinger, M
   Müller-Stierlin, A
   Serban, AC
   Ben-Sheetrit, J
   Vejnovic, AM
   Butler, MI
   Balanzá-Martínez, V
   Zaja, N
   Rus-Prelog, P
   Strumila, R
   Teasdale, SB
   Reininghaus, EZ
   Holasek, SJ
AF Moerkl, Sabrina
   Stell, Linda
   Buhai, Diana, V
   Schweinzer, Melanie
   Wagner-Skacel, Jolana
   Vajda, Christian
   Lackner, Sonja
   Bengesser, Susanne A.
   Lahousen, Theresa
   Painold, Annamaria
   Oberascher, Andreas
   Tatschl, Josef M.
   Fellinger, Matthaeus
   Mueller-Stierlin, Annabel
   Serban, Ana C.
   Ben-Sheetrit, Joseph
   Vejnovic, Ana-Marija
   Butler, Mary, I
   Balanza-Martinez, Vicent
   Zaja, Nikola
   Rus-Prelog, Polona
   Strumila, Robertas
   Teasdale, Scott B.
   Reininghaus, Eva Z.
   Holasek, Sandra J.
TI 'An Apple a Day'?: Psychiatrists, Psychologists and Psychotherapists
   Report Poor Literacy for Nutritional Medicine: International Survey
   Spanning 52 Countries
SO NUTRIENTS
LA English
DT Article
DE nutritional psychiatry; mental health professionals; psychiatrists;
   psychologists; psychotherapists; education; psychiatric disorders; diet;
   supplements; nutrition
ID MEDITERRANEAN DIETARY PATTERN; POLYUNSATURATED FATTY-ACIDS; MAJOR
   DEPRESSIVE DISORDER; DOUBLE-BLIND; MENTAL-DISORDERS; INOSITOL TREATMENT;
   METABOLIC SYNDROME; HEALTH-BENEFITS; EDIBLE SEAWEED; OLDER-ADULTS
AB Nutritional interventions have beneficial effects on certain psychiatric disorder symptomatology and common physical health comorbidities. However, studies evaluating nutritional literacy in mental health professionals (MHP) are scarce. This study aimed to assess the across 52 countries. Surveys were distributed via colleagues and professional societies. Data were collected regarding self-reported general nutrition knowledge, nutrition education, learning opportunities, and the tendency to recommend food supplements or prescribe specific diets in clinical practice. In total, 1056 subjects participated in the study: 354 psychiatrists, 511 psychologists, 44 psychotherapists, and 147 MHPs in-training. All participants believed the diet quality of individuals with mental disorders was poorer compared to the general population (p < 0.001). The majority of the psychiatrists (74.2%) and psychologists (66.3%) reported having no training in nutrition. Nevertheless, many of them used nutrition approaches, with 58.6% recommending supplements and 43.8% recommending specific diet strategies to their patients. Only 0.8% of participants rated their education regarding nutrition as 'very good.' Almost all (92.9%) stated they would like to expand their knowledge regarding 'Nutritional Psychiatry.' There is an urgent need to integrate nutrition education into MHP training, ideally in collaboration with nutrition experts to achieve best practice care.
C1 [Moerkl, Sabrina; Stell, Linda; Bengesser, Susanne A.; Lahousen, Theresa; Painold, Annamaria; Reininghaus, Eva Z.] Med Univ Graz, Dept Psychiat & Psychotherapeut Med, A-8036 Graz, Austria.
   [Buhai, Diana, V] Iuliu Hatieganu Univ Med & Pharm, Fac Med, Cluj Napoca 400000, Romania.
   [Schweinzer, Melanie; Wagner-Skacel, Jolana; Vajda, Christian] Med Univ Graz, Dept Med Psychol & Psychotherapy, A-8036 Graz, Austria.
   [Lackner, Sonja; Holasek, Sandra J.] Med Univ Graz, Div Immunol & Pathophysiol, Otto Loewi Res Ctr Vasc Biol Immunol & Inflammat, A-8036 Graz, Austria.
   [Oberascher, Andreas] Christian Doppler Klin, Dept Psychotherapy & Psychosomat, Univ Clin Psychiat, A-5020 Salzburg, Austria.
   [Tatschl, Josef M.] Karl Franzens Univ Graz, Inst Psychol, Hlth Psychol Unit, A-8010 Graz, Austria.
   [Fellinger, Matthaeus] Med Univ Vienna, Dept Psychiat & Psychotherapy, Clin Div Social Psychiat, A-1090 Vienna, Austria.
   [Mueller-Stierlin, Annabel] Ulm Univ, Dept Psychiat & Psychotherapy 2, D-89070 Ulm, Germany.
   [Serban, Ana C.] Psychotherapist Cognit Behav Therapy, Private Sect, 26-28 Dumitru Sergiu St,Sect 1, Bucharest 011026, Romania.
   [Ben-Sheetrit, Joseph] 3HaNechoshet St, IL-6971068 Tel Aviv, Israel.
   [Vejnovic, Ana-Marija] Univ Novi Sad, Fac Med, Dept Psychiat & Psychol Med, Novi Sad 21137, Serbia.
   [Vejnovic, Ana-Marija] Clin Ctr Vojvodina, Clin Psychiat, Novi Sad 21000, Serbia.
   [Butler, Mary, I] Univ Coll Cork, Dept Psychiat & Clin Neurosci, Cork T12 YT20, Ireland.
   [Balanza-Martinez, Vicent] Univ Valencia, Dept Med, Teaching Unit Psychiat & Psychol Med, CIBERSAM, Valencia 46010, Spain.
   [Zaja, Nikola] Univ Zagreb, Univ Psychiat Hosp VrapCe, Sch Med, Zagreb 10000, Croatia.
   [Rus-Prelog, Polona] Univ Psychiat Clin Ljubljana, Ctr Clin Psychiat, Ljubljana 1260, Slovenia.
   [Strumila, Robertas] Vilnius Univ, Fac Med, Inst Clin Med, Clin Psychiat, LT-03101 Vilnius, Lithuania.
   [Strumila, Robertas] Univ Montpellier, CHU Montpellier, INSERM, Dept Psychiat Emergency & Acute Care,Lapeyronie H, F-34295 Montpellier, France.
   [Teasdale, Scott B.] UNSW Sydney, Sch Psychiat, Sydney, NSW 2052, Australia.
C3 Medical University of Graz; Iuliu Hatieganu University of Medicine &
   Pharmacy; Medical University of Graz; Medical University of Graz;
   University of Graz; Medical University of Vienna; Ulm University;
   University of Novi Sad; University College Cork; University of Valencia;
   CIBER - Centro de Investigacion Biomedica en Red; CIBERSAM; University
   of Zagreb; University Medical Centre Ljubljana; Vilnius University;
   Universite de Montpellier; Institut National de la Sante et de la
   Recherche Medicale (Inserm); CHU de Montpellier; University of New South
   Wales Sydney
RP Bengesser, SA (corresponding author), Med Univ Graz, Dept Psychiat & Psychotherapeut Med, A-8036 Graz, Austria.
EM sabrina.moerkl@medunigraz.at; linda.stell@stud.medunigraz.at;
   buhaidiana@gmail.com; melanie.schweinzer@medunigraz.at;
   jolana.wagner-skacel@medunigraz.at; christian.vajda@medunigraz.at;
   sonja.lackner@medunigraz.at; susanne.bengesser@medunigraz.at;
   theresa.lahousen@medunigraz.at; annamaria.painold@medunigraz.at;
   a.oberascher@salk.at; josef.tatschl@uni-graz.at;
   matthaeus.fellinger@meduniwien.ac.at;
   annabel.mueller-stierlin@uni-ulm.de; ana_serban1990@yahoo.com;
   joseph.ben.sheetrit@gmail.com; ana-marija.vejnovic@mf.uns.ac.rs;
   mary.butler@ucc.ie; vicente.balanza@uv.es; zaja.nikola@gmail.com;
   ruspolona@gmail.com; robertas.strumila@gmail.com;
   scottbteasdale@gmail.com; eva.reininghaus@medunigraz.at;
   sandra.holasek@medunigraz.at
RI Mueller-Stierlin, Annabel/AAC-1241-2022; Balanzá-Martínez,
   Vicent/C-3073-2011; Fellinger, Matthäus/AAX-6887-2020; Rus Prelog,
   Polona/HKM-4165-2023; Teasdale, Scott/AFP-0676-2022
OI Butler, Mary/0000-0002-7918-533X; Morkl, Sabrina/0000-0001-5034-6358; ,
   theresa/0000-0002-0285-3555; Fellinger, Matthaus/0000-0003-4859-1949;
   /0000-0002-9328-0915; Vajda, Christian/0000-0001-6297-6576;
   Mueller-Stierlin, Annabel Sandra/0000-0003-2812-5115; Painold,
   Annamaria/0000-0002-7372-8655; Balanza-Martinez,
   Vicent/0000-0001-7772-7396; Zaja, Nikola/0000-0002-3363-5614;
   Wagner-Skacel, Jolana/0000-0003-0771-4543; Tatschl, Josef
   Martin/0000-0003-1594-1770; Teasdale, Scott/0000-0001-6769-8421;
   Holasek, Sandra/0000-0002-2958-3516
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NR 142
TC 22
Z9 24
U1 2
U2 15
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD MAR
PY 2021
VL 13
IS 3
AR 822
DI 10.3390/nu13030822
PG 26
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nutrition & Dietetics
GA RE2JR
UT WOS:000633987800001
PM 33801454
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Jahrami, H
   Trabelsi, K
   Alhaj, OA
   Saif, Z
   Pandi-Perumal, SR
   BaHammam, AS
AF Jahrami, Haitham
   Trabelsi, Khaled
   Alhaj, Omar A.
   Saif, Zahra
   Pandi-Perumal, Seithikurippu R.
   BaHammam, Ahmed S.
TI The impact of Ramadan fasting on the metabolic syndrome severity in
   relation to ethnicity and sex: Results of a systematic review and
   meta-analysis
SO NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
LA English
DT Review
DE Cardiometabolic syndrome; Insulin resistance syndrome X; Intermittent
   fasting (IF); Metabolism; Reaven syndrome X; Time-restricted eating
   (TRE)
ID DENSITY-LIPOPROTEIN-CHOLESTEROL; CORONARY-HEART-DISEASE;
   BODY-COMPOSITION; LIPID PROFILE; HEMATOLOGICAL PARAMETERS; BIOCHEMICAL
   PARAMETERS; BLOOD-PRESSURE; PROVISIONAL REPORT; MEDICAL-STUDENTS;
   OXIDATIVE STRESS
AB Aims: The primary goal of this meta-analysis was to examine the changes in various components of metabolic syndrome (MetS) in healthy adults who observed Ramadan fasting (RF) before Ramadan (T1) and at the end of RF (T2). A secondary goal was to assess the impact of RF on MetS severity in various ethnic and sex groups using the MetS z-score.Data synthesis: Using PRISMA2020, seven databases were searched for relevant studies published between January 1950 and March 2022. Data extraction involved high-density lipoprotein cholesterol (HDL), triglycerides (TG), fasting blood glucose (FBG), waist circumference (WC), sys-tolic blood pressure (SBP), and diastolic blood pressure (DBP) for T1 and T2, respectively. The MetS z-score was computed according to international diabetes federation criteria. At T1, the pooled estimates of HDL, TG, FBG, WC, SBP, DBP, and MAP were 1.20 [1.13; 1.27] mmol/L, 1.32 [1.23; 1.42] mmol/L, 4.98 [4.82; 5.15] mmol/L, 87.21 [84.21; 90.21] Cm, 114.22 [101.45; 126.99] mmHg, 76.80 [70.12; 83.47] mmHg, and 89.27 [80.56; 97.98] mmHg, respectively. At T2, the pooled estimates of HDL, TG, FBG, WC, SBP, DBP, and MAP were 1.24 [1.18; 1.31] mmol/L, 1.24 [1.14; 1.34] mmol/L, 4.77 [4.55; 4.99] mmol/L, 85.73 [82.83; 88.64] Cm, 109.48 [97.20; 121.75] mmHg, 74.43 [68.01; 80.85] mmHg, and 86.11 [77.74; 94.48] mmHg, respectively. The MetS z -score showed improvement at T2 for all ethnic groups and both sexes by-0.22 [-0.24;-0.01]. Conclusions: The current meta-analysis suggests that the RF positively impact the MetS compo-nents and the overall MetS z-score.PROSPERO registration number: ID CRD42022329297Open Science Framework Identifier: DOI 10.17605/OSF.IO/U9H7T (c) 2022 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Ital-ian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.
C1 [Jahrami, Haitham; Saif, Zahra] Minist Hlth, Manama, Bahrain.
   [Jahrami, Haitham] Arabian Gulf Univ, Coll Med & Med Sci, Dept Psychiat, Manama, Bahrain.
   [Trabelsi, Khaled] Univ Sfax, High Inst Sport & Phys Educ Sfax, Sfax 3000, Tunisia.
   [Trabelsi, Khaled] Univ Sfax, Res Lab Educ Motr Sport & Hlth, EM2S, LR19JS01, Sfax 3000, Tunisia.
   [Alhaj, Omar A.] Univ Petra, Fac Pharm & Med Sci, Dept Nutr, Amman, Jordan.
   [Pandi-Perumal, Seithikurippu R.] Somnogen Canada Inc, Coll St, Toronto, ON, Canada.
   [Pandi-Perumal, Seithikurippu R.] Saveetha Univ, Saveetha Med Coll & Hosp, Saveetha Inst Med & Tech Sci, Chennai, Tamil Nadu, India.
   [BaHammam, Ahmed S.] Natl Plan Sci & Technol & Innovat Kingdom Saudi Ar, Strateg Technol Program, Riyadh, Saudi Arabia.
   [BaHammam, Ahmed S.] King Saud Univ, Univ Sleep Disorders Ctr, Dept Med, KSA6, Riyadh, Saudi Arabia.
   [BaHammam, Ahmed S.] King Saud Univ, Pulm Serv, Dept Psychiat, KSA6, Riyadh, Saudi Arabia.
C3 Ministry of Health - Bahrain; Arabian Gulf University; Universite de
   Sfax; Universite de Sfax; Petra University; Saveetha Institute of
   Medical & Technical Science; Saveetha Medical College & Hospital; King
   Saud University; King Saud University
RP Jahrami, H (corresponding author), Arabian Gulf Univ, Coll Med & Med Sci, Dept Psychiat, Manama, Bahrain.
EM hjahrami@health.gov.bh; trabelsikhaled@gmail.com; omar.alhaj@uop.edu.jo;
   zsaif@health.gov.bh; pandiperumal2021@gmail.com;
   trabelsikhaled@gmail.com
RI Pandi-Perumal, Seithikurippu/Q-8281-2016; Jahrami,
   Haitham/JVO-6632-2024; Alhaj, Omar/GNM-7230-2022; Khaled,
   Trabelsi/ABG-2717-2020; BaHammam, Ahmed/B-9037-2008; Pandi-Perumal,
   Seithikurippu R/C-6767-2008
OI Alhaj, Omar/0000-0003-0082-3843; Khaled, Trabelsi/0000-0003-2623-9557;
   BaHammam, Ahmed/0000-0002-1706-6167; Pandi-Perumal, Seithikurippu
   R/0000-0002-8686-7259
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   Ziaee V., 2006, SMJ Singapore Medical Journal, V47, P409
NR 156
TC 14
Z9 14
U1 1
U2 8
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 0939-4753
EI 1590-3729
J9 NUTR METAB CARDIOVAS
JI Nutr. Metab. Carbiovasc. Dis.
PD DEC
PY 2022
VL 32
IS 12
BP 2714
EP 2729
DI 10.1016/j.numecd.2022.09.001
EA NOV 2022
PG 16
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism; Nutrition
   & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism;
   Nutrition & Dietetics
GA 8I0GL
UT WOS:000921405800005
PM 36333203
DA 2025-06-11
ER

PT J
AU Herder, C
   Kannenberg, JM
   Huth, C
   Carstensen-Kirberg, M
   Rathmann, W
   Koenig, W
   Strom, A
   Bönhof, GJ
   Heier, M
   Thorand, B
   Peters, A
   Roden, M
   Meisinger, C
   Ziegler, D
AF Herder, Christian
   Kannenberg, Julia M.
   Huth, Cornelia
   Carstensen-Kirberg, Maren
   Rathmann, Wolfgang
   Koenig, Wolfgang
   Strom, Alexander
   Boenhof, Gidon J.
   Heier, Margit
   Thorand, Barbara
   Peters, Annette
   Roden, Michael
   Meisinger, Christa
   Ziegler, Dan
TI Myeloperoxidase, superoxide dismutase-3, cardiometabolic risk factors,
   and distal sensorimotor polyneuropathy: The KORA F4/FF4 study
SO DIABETES-METABOLISM RESEARCH AND REVIEWS
LA English
DT Article
DE cardiovascular risk factors; myeloperoxidase; neuropathy; oxidative
   stress; polyneuropathy; superoxide dismutase
ID SUBCLINICAL INFLAMMATION; DIABETIC POLYNEUROPATHY; OXIDATIVE STRESS;
   SERUM-LEVELS; POPULATION; ASSOCIATION; ANTAGONIST; NEUROPATHY;
   METHYLGLYOXAL; ADIPONECTIN
AB BackgroundOxidative stress has been proposed as important pathomechanism of cardiometabolic diseases and distal sensorimotor polyneuropathy (DSPN). However, the relevance of biomarkers of oxidative stress has not been investigated in this context. Therefore, this study aimed to assess the association of the prooxidant myeloperoxidase (MPO) and the antioxidant extracellular superoxide dismutase (SOD3) with cardiometabolic risk factors and with prevalence and incidence of DSPN.
   MethodsCross-sectional analyses comprised 1069 participants (40.3% with prediabetes and 20.5% with type 2 diabetes) of the population-based Cooperative Health Research in the Region of Augsburg (KORA) F4 study (2006-2008), 181 of whom had DSPN at baseline. Prospective analyses included 524 individuals without DSPN at baseline who also participated in the KORA FF4 study (2013-2014), 132 of whom developed DSPN during the 6.5-year follow-up. Serum MPO and SOD3 were measured by ELISA, and their association with cardiometabolic risk factors and DSPN were estimated by using linear and logistic regression analyses.
   ResultsHigher MPO and SOD levels showed multiple positive associations with cardiometabolic risk factors including age, indices of obesity, insulin resistance, serum lipids, renal dysfunction, and biomarkers of inflammation. Higher MPO levels were associated with prevalent DSPN (fully adjusted OR 1.38 [95% CI 1.10; 1.72] per doubling of MPO). Higher baseline SOD3 levels were related to incident DSPN (age and sex-adjusted OR 2.14 [1.02; 4.48] per doubling of SOD3), which was partially explained by cardiometabolic risk factors.
   ConclusionsSystemic levels of both pro- and antioxidant enzymes appear involved in cardiometabolic risk and development of DSPN.
C1 [Herder, Christian; Kannenberg, Julia M.; Carstensen-Kirberg, Maren; Strom, Alexander; Boenhof, Gidon J.; Roden, Michael; Ziegler, Dan] Heinrich Heine Univ Dusseldorf, Inst Clin Diabetol, German Diabet Ctr, Leibniz Ctr Diabet Res, Aufm Hennekamp 65, D-40225 Dusseldorf, Germany.
   [Herder, Christian; Kannenberg, Julia M.; Huth, Cornelia; Carstensen-Kirberg, Maren; Rathmann, Wolfgang; Strom, Alexander; Thorand, Barbara; Peters, Annette; Roden, Michael; Meisinger, Christa; Ziegler, Dan] German Ctr Diabet Res DZD, Munich, Germany.
   [Huth, Cornelia; Heier, Margit; Thorand, Barbara; Peters, Annette; Meisinger, Christa] German Res Ctr Environm Hlth, Inst Epidemiol, Helmholtz Zentrum Munchen, Neuherberg, Germany.
   [Rathmann, Wolfgang] Heinrich Heine Univ Dusseldorf, Inst Biometr & Epidemiol, German Diabet Ctr, Leibniz Ctr Diabet Res, Dusseldorf, Germany.
   [Koenig, Wolfgang] Tech Univ Munich, Deutsch Herzzentrum Munchen, Munich, Germany.
   [Koenig, Wolfgang] German Ctr Cardiovasc Res DZHK, Partner Site Munich Heart Alliance, Munich, Germany.
   [Roden, Michael; Ziegler, Dan] Heinrich Heine Univ, Fac Med, Div Endocrinol & Diabetol, Dusseldorf, Germany.
   [Meisinger, Christa] Ludwig Maximilian Univ Munchen, UNIKA T Augsburg, Chair Epidemiol, Augsburg, Germany.
C3 Heinrich Heine University Dusseldorf; Leibniz Association; Deutsches
   Diabetes-Zentrum (DDZ); German Center for Diabetes Research (DZD);
   Helmholtz Association; Helmholtz-Center Munich - German Research Center
   for Environmental Health; Leibniz Association; Deutsches
   Diabetes-Zentrum (DDZ); Heinrich Heine University Dusseldorf; German
   Heart Centre Munich; Technical University of Munich; Munich Heart
   Alliance; German Centre for Cardiovascular Research; Heinrich Heine
   University Dusseldorf
RP Herder, C (corresponding author), Heinrich Heine Univ Dusseldorf, Inst Clin Diabetol, German Diabet Ctr, Leibniz Ctr Diabet Res, Aufm Hennekamp 65, D-40225 Dusseldorf, Germany.
EM christian.herder@ddz.uni-duesseldorf.de
RI Huth, Cornelia/B-5350-2014; Roden, Michael/AAD-3843-2019; Meisinger,
   Christine/B-5358-2014; Koenig, Wolfgang/JCF-0788-2023; Heier,
   Margit/AAT-5280-2020; Qasrawi, Radwan/AAA-6245-2019; Peters,
   Annette/A-6117-2011; Thorand, Barbara/B-5349-2014
OI Koenig, Wolfgang/0000-0002-2064-9603; Peters,
   Annette/0000-0001-6645-0985; Roden, Michael/0000-0001-8200-6382;
   Thorand, Barbara/0000-0002-8416-6440
FU State of Bavaria; German Federal Ministry of Education and Research;
   German Center for Diabetes Research; Deutsche Forschungsgemeinschaft [RA
   459/3-1]; German Federal Ministry of Health; Ministry of Culture and
   Science of the State of North Rhine-Westphalia; German Diabetes
   Association
FX State of Bavaria; German Federal Ministry of Education and Research;
   German Center for Diabetes Research; Deutsche Forschungsgemeinschaft,
   Grant/Award Number: RA 459/3-1; German Federal Ministry of Health;
   Ministry of Culture and Science of the State of North Rhine-Westphalia;
   German Diabetes Association
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NR 46
TC 20
Z9 21
U1 0
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1520-7552
EI 1520-7560
J9 DIABETES-METAB RES
JI Diabetes-Metab. Res. Rev.
PD JUL
PY 2018
VL 34
IS 5
AR e3000
DI 10.1002/dmrr.3000
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA GL6EO
UT WOS:000437274400008
PM 29577557
DA 2025-06-11
ER

PT J
AU de Kluiver, H
   Milaneschi, Y
   Jansen, R
   van Sprang, ED
   Giltay, EJ
   Hartman, CA
   Penninx, BWJH
AF de Kluiver, Hilde
   Milaneschi, Yuri
   Jansen, Rick
   van Sprang, Eleonore D.
   Giltay, Erik J.
   Hartman, Catharina A.
   Penninx, Brenda W. J. H.
TI Associations between depressive symptom profiles and immunometabolic
   characteristics in individuals with depression and their siblings
SO WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
LA English
DT Article
DE Atypical depression; siblings; inflammation; BMI; familial resemblance
ID C-REACTIVE PROTEIN; BODY-MASS INDEX; METABOLIC SYNDROME; FAMILIAL
   AGGREGATION; ATYPICAL FEATURES; ANXIETY DISORDERS; MAJOR DEPRESSION;
   FOOD PREFERENCES; NATIONAL-HEALTH; BLOOD-PRESSURE
AB Objectives: The present study examined associations between immunometabolic characteristics (IMCs) and depressive symptom profiles (DSPs) in probands with lifetime diagnoses of depression and/or anxiety disorders and their siblings. Methods: Data were from the Netherlands Study of Depression and Anxiety, comprising 256 probands with lifetime diagnoses of depression and/or anxiety and their 380 siblings. Measured IMCs included blood pressure, waist circumference, and levels of glucose, triglycerides, HDL cholesterol, CRP, TNF-alpha and IL-6. DSPs included mood, cognitive, somatic and atypical-like profiles. We cross-sectionally examined whether DSPs were associated with IMCs within probands and within siblings, and whether DSPs were associated with IMCs between probands and siblings. Results: Within probands and within siblings, higher BMI and waist circumference were associated with higher somatic and atypical-like profiles. Other IMCs (IL-6, glucose and HDL cholesterol) were significantly related to DSPs either within probands or within siblings. DSPs and IMCs were not associated between probands and siblings. Conclusions: The results suggest that there is a familial component for each trait, but no common familial factors for the association between DSPs and IMCs. Alternative mechanisms, such as direct causal effects or non-shared environmental risk factors, may better fit these results.
C1 [de Kluiver, Hilde; Milaneschi, Yuri; Jansen, Rick; van Sprang, Eleonore D.; Penninx, Brenda W. J. H.] Vrije Univ Amsterdam, Dept Amsterdam Publ Hlth Res Inst, Amsterdam UMC, Dept Psychiat, Amsterdam, Netherlands.
   [de Kluiver, Hilde; Milaneschi, Yuri; Jansen, Rick; van Sprang, Eleonore D.; Penninx, Brenda W. J. H.] Vrije Univ Amsterdam, Amsterdam Neurosci, Amsterdam, Netherlands.
   [Giltay, Erik J.] Leiden Univ, Dept Psychiat, Med Ctr, Leiden, Netherlands.
   [Hartman, Catharina A.] Univ Groningen, Univ Med Ctr Groningen, Interdisciplinary Ctr Psychopathol & Emot Regulat, Groningen, Netherlands.
C3 Vrije Universiteit Amsterdam; University of Amsterdam; Vrije
   Universiteit Amsterdam; Leiden University - Excl LUMC; Leiden
   University; Leiden University Medical Center (LUMC); University of
   Groningen
RP de Kluiver, H (corresponding author), Oldenaller 1, NL-1081 HJ Amsterdam, Netherlands.
EM c.dekluiver@amsterdamumc.nl
RI Giltay, Erik/AAL-9948-2021; Jansen, Ritsert/C-1160-2013; Penninx, Brenda
   WJH/S-7627-2017
OI Penninx, Brenda WJH/0000-0001-7779-9672; Giltay, Erik
   J./0000-0001-8874-2292; , Hilde/0000-0003-4835-189X; van Sprang,
   Eleonore/0000-0001-6532-5496; Jansen, Rick/0000-0002-3333-6737;
   Milaneschi, Yuri/0000-0002-3697-6617
FU Netherlands Organisation for Health Research and Development (ZonMw)
   [10-000-1002]; VU University Medical Centre; GGZ inGeest; Leiden
   University Medical Centre; Leiden University; GGZ Rivierduinen;
   University Medical Centre Groningen; University of Groningen; Lentis;
   GGZ Friesland; GGZ Drenthe; Rob Giel Onderzoekscentrum
FX The infrastructure for the NESDA study (www.nesda.nl) is funded through
   the Geestkracht programme of the Netherlands Organisation for Health
   Research and Development (ZonMw, grant number 10-000-1002) and financial
   contributions by participating universities and mental health care
   organisations (VU University Medical Centre, GGZ inGeest, Leiden
   University Medical Centre, Leiden University, GGZ Rivierduinen,
   University Medical Centre Groningen, University of Groningen, Lentis,
   GGZ Friesland, GGZ Drenthe, Rob Giel Onderzoekscentrum).
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NR 84
TC 8
Z9 8
U1 0
U2 2
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1562-2975
EI 1814-1412
J9 WORLD J BIOL PSYCHIA
JI World J. Biol. Psychiatry
PD FEB 7
PY 2021
VL 22
IS 2
BP 128
EP 138
DI 10.1080/15622975.2020.1761562
EA MAY 2020
PG 11
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA SY0IZ
UT WOS:000537020000001
PM 32425087
OA Green Published, Green Submitted, hybrid
DA 2025-06-11
ER

PT J
AU Huang, CY
   Chi, SC
   Sousa, VD
   Wang, CP
   Pan, KC
AF Huang, Chiung-Yu
   Chi, Shu-Ching
   Sousa, Valmi D.
   Wang, Chao-Ping
   Pan, Kuei-Ching
TI Depression, coronary artery disease, type 2 diabetes, metabolic syndrome
   and quality of life in Taiwanese adults from a cardiovascular department
   of a major hospital in Southern Taiwan
SO JOURNAL OF CLINICAL NURSING
LA English
DT Article
DE coronary artery disease; depression; metabolic syndrome; quality of
   life; type 2 diabetes
ID 3RD NATIONAL-HEALTH; RISK-FACTOR; FAMILY CAREGIVERS; SOCIAL SUPPORT;
   HEART-DISEASE; YOUNG-ADULTS; EPIDEMIOLOGY; PREVALENCE; SYMPTOMS;
   MORTALITY
AB Aims.
   To examine the relationships between depression, coronary artery disease, type 2 diabetes, metabolic syndrome and quality of life in Taiwanese adults from a cardiovascular department of a major hospital in Taiwan.
   Background.
   Research suggests associations between depression, metabolic syndrome and quality of life. Despite this fact, few studies have investigated these relationships among Taiwanese.
   Design.
   A cross-sectional descriptive correlational design was used to conduct this study.
   Methods.
   A convenience sample of 140 adults participated in the study. Data were analysed with descriptive statistics, Pearson's correlations, hierarchical regression and t-tests.
   Results.
   Almost a half of the subjects (46 center dot 5%) had metabolic syndrome. The most common combination of metabolic syndrome criteria was elevated blood glucose, central obesity and high blood pressure (23 center dot 7%). A greater number of individuals had coronary artery disease (72 center dot 9%), type 2 diabetes (35%) and/or depression (21 center dot 4%). Type 2 diabetes and depression were significant predictors of overall quality of life (beta = -0 center dot 16, p < 0 center dot 01 and beta = -0 center dot 63, p < 0 center dot 001, respectively). In addition, there were significant differences between individuals with and without type 2 diabetes and/or depression regarding overall quality of life scores; t (138) = 3 center dot 50, p < 0 center dot 01); and t (138) = 7 center dot 80, p < 0 center dot 001), respectively.
   Conclusions.
   Coronary artery disease, type 2 diabetes and depression were common among our sample of individuals with metabolic syndrome. Those with diabetes and/or depression had worse quality of life than those without those diseases.
   Relevance to clinical practice.
   Nurses need to be prepared to assess and intervene in preventing or treating depression among patients with chronic diseases, especially those with coronary artery disease, type 2 diabetes and metabolic syndrome. When individuals are treated for depression, they are more likely to engage in self-management of their diseases, which will prevent complications and improve their quality of life.
C1 [Huang, Chiung-Yu] I Shou Univ, Yanchao Hsiang, Kaohsiung Cty, Taiwan.
   [Chi, Shu-Ching; Pan, Kuei-Ching] E Da Hosp, Dept Nursing, Kaohsiung Cty, Taiwan.
   [Sousa, Valmi D.] Univ Kansas, Sch Nursing, Kansas City, KS USA.
   [Wang, Chao-Ping] E Da Hosp, Dept Cardiol, Kaohsiung Cty, Taiwan.
C3 I Shou University; E-Da Hospital; University of Kansas; E-Da Hospital
RP Huang, CY (corresponding author), I Shou Univ, 8 Yida Rd, Yanchao Hsiang, Kaohsiung Cty, Taiwan.
EM chyh@isu.edu.tw
RI Huang, Chiung-Yu/T-9577-2019
FU E-Da Hospital, Taiwan [E-MRP-096-072]
FX This study was funded by the E-Da Hospital, Taiwan (Grant
   E-MRP-096-072). The authors thank the patients who participated in this
   study. They also thank the physicians and nurses who assisted in the
   recruitment of participants and data collection.
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NR 49
TC 11
Z9 14
U1 0
U2 16
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0962-1067
EI 1365-2702
J9 J CLIN NURS
JI J. Clin. Nurs.
PD MAY
PY 2011
VL 20
IS 9-10
BP 1293
EP 1302
DI 10.1111/j.1365-2702.2010.03451.x
PG 10
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA 751PQ
UT WOS:000289630400010
PM 21492275
DA 2025-06-11
ER

PT J
AU Kim, WK
   Shin, D
   Song, WO
AF Kim, Woo Kyoung
   Shin, Dayeon
   Song, Won O.
TI Depression and Its Comorbid Conditions More Serious in Women than in Men
   in the United States
SO JOURNAL OF WOMENS HEALTH
LA English
DT Article
ID C-REACTIVE PROTEIN; METABOLIC SYNDROME; INSULIN-RESISTANCE;
   YOUNG-ADULTS; PREVALENCE; DISEASE; GLUCOSE; EPIDEMIOLOGY; DISORDER;
   EPISODES
AB Background: Depression is a major public health problem by itself and for its comorbid conditions. We aimed to determine gender differences in the prevalence of depression and how depression is related to comorbid conditions and metabolic biomarkers. Methods: This study included men (n=986) and women (n=1,280) aged 20-79 years who were included in the 2007-2010 National Health and Nutrition Examination Survey. Depression was assessed with the Patient Health Questionnaire (PHQ-9). The associations between depression (PHQ-9 score 10), self-reported comorbid conditions, and metabolic biomarkers of comorbid conditions were determined by multivariable logistic regressions adjusting for potential confounders. Results: The prevalence of depression in men and women were 7.9% and 12.1%, respectively (p<0.01). The odds ratios (OR) of various comorbid conditions (asthma, arthritis, gout, coronary heart disease, heart attack, stroke, diabetes mellitus, thyroid problem, and metabolic syndrome) by the status of depression were significantly higher in women. High C-reactive protein (CRP) was a significant predictor of depression in men (OR 2.02, 95% confidence interval [CI] 1.11-3.67) in unadjusted model. In women, high fasting blood glucose, high glycohemoglobin, and high CRP were significant predictors of depression (OR 1.20, 95% CI 1.28-3.01; OR 2.44, 95% CI 1.21-4.92; OR 1.44, 95% CI 1.01-2.06; OR 1.79, 95% CI 0.19-2.67, respectively) after controlling for age, education, race/ethnicity, marital status, ratio of family income to poverty, and physical activity. Conclusions: Women had higher prevalence of depression and higher number of significant associations between socioeconomic status, comorbid conditions, and metabolic risk factors by the status of depression than men. Public health attentions are needed to improve women's mental health.
C1 [Kim, Woo Kyoung] Dankook Univ, Dept Food Sci & Nutr, Yongin, Gyeonggi Do, South Korea.
   [Shin, Dayeon; Song, Won O.] Michigan State Univ, Dept Food Sci & Human Nutr, E Lansing, MI 48824 USA.
C3 Dankook University; Michigan State University
RP Song, WO (corresponding author), Michigan State Univ, Dept Food Sci & Human Nutr, 469 Wilson Rd,Room 135A, E Lansing, MI 48824 USA.
EM song@msu.edu
RI Shin, Dayeon/GMX-2004-2022
OI Shin, Dayeon/0000-0003-0828-184X
FU Dankook University
FX The present research was conducted by the research fund of Dankook
   University in 2014.
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NR 39
TC 24
Z9 29
U1 0
U2 13
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-9996
EI 1931-843X
J9 J WOMENS HEALTH
JI J. Womens Health
PD DEC 1
PY 2015
VL 24
IS 12
BP 978
EP 985
DI 10.1089/jwh.2014.4919
PG 8
WC Public, Environmental & Occupational Health; Medicine, General &
   Internal; Obstetrics & Gynecology; Women's Studies
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; General & Internal
   Medicine; Obstetrics & Gynecology; Women's Studies
GA CY5LB
UT WOS:000366448000006
PM 26131726
DA 2025-06-11
ER

PT J
AU Rissanen, T
   Lehto, SM
   Hintikka, J
   Honkalampi, K
   Saharinen, T
   Viinamäki, H
   Koivumaa-Honkanen, H
AF Rissanen, Teemu
   Lehto, Soili M.
   Hintikka, Jukka
   Honkalampi, Kirsi
   Saharinen, Tarja
   Viinamaki, Heimo
   Koivumaa-Honkanen, Heli
TI Biological and other health related correlates of long-term life
   dissatisfaction burden
SO BMC PSYCHIATRY
LA English
DT Article
DE Life satisfaction; Burden; Social support; Inflammation; Adiponectin;
   Metabolic syndrome
ID TORONTO-ALEXITHYMIA-SCALE; METABOLIC SYNDROME; MENTAL-HEALTH;
   ADIPONECTIN LEVELS; FOLLOW-UP; SATISFACTION; WELL; SLEEP; INFLAMMATION;
   ASSOCIATION
AB Background: Mental health is interconnected with somatic health and can manifest itself in biological processes. Life dissatisfaction is an indicator of subjective well-being, but information on its biological correlates is scarce. The aim of this study was to investigate the biological correlates along with other health-related factors of long-term life dissatisfaction in a population-based sample.
   Methods: As part of the Kuopio Depression Study, health questionnaires were sent to a randomly selected population-based sample in 1998, 1999, and 2001. In 2005, among a clinically studied sub-sample (n = 305), the 7-year long-term life dissatisfaction burden was assessed by summing life satisfaction scores from previous health questionnaires. Several sociodemographic, health, health behavior, and biological factors were investigated in respect to their associations to categorized (low and high) and continuous (linear regression) life satisfaction burden score (higher values indicating dissatisfaction).
   Results: In the final linear regression model long-term life dissatisfaction burden was significantly associated with poor social support (B = 0.138; p < 0.001), marital status (i.e. living alone) (B = 0.049; p = 0.019), current smoking (B = 0.087; p < 0.001), poor sleep (B = 0.052; p = 0.001), use of statins (B = -0.052; p = 0.002) and lower serum adiponectin level (B = -0.001; p = 0.039) whereas association of metabolic syndrome was marginally nonsignificant (B = 0.029; p = 0.055).
   Conclusion: Long-term life dissatisfaction is associated with adverse health, health behavioral, and social factors, as well as with a decreased anti-inflammatory buffer capacity, all indicating close relationships between subjective well-being and somatic morbidity.
C1 [Rissanen, Teemu; Saharinen, Tarja; Viinamaki, Heimo; Koivumaa-Honkanen, Heli] Kuopio Univ Hosp, Dept Psychiat, FI-70211 Kuopio, Finland.
   [Rissanen, Teemu; Hintikka, Jukka] Paijat Hame Cent Hosp, Dept Psychiat, Lahti, Finland.
   [Lehto, Soili M.; Viinamaki, Heimo; Koivumaa-Honkanen, Heli] Univ Eastern Finland, Sch Clin Med, Kuopio, Finland.
   [Hintikka, Jukka] Univ Tampere, Inst Clin Med, FIN-33101 Tampere, Finland.
   [Honkalampi, Kirsi] Univ Eastern Finland, Sch Educ Sci & Psychol, Joensuu, Finland.
   [Koivumaa-Honkanen, Heli] South Savonia Hosp Dist, Dept Psychiat, Mikkeli, Finland.
   [Koivumaa-Honkanen, Heli] North Karelia Cent Hosp, Dept Psychiat, Joensuu, Finland.
   [Koivumaa-Honkanen, Heli] SOSTERI, Dept Psychiat, Savonlinna, Finland.
   [Koivumaa-Honkanen, Heli] SOTE, Dept Psychiat, Iisalmi, Finland.
   [Koivumaa-Honkanen, Heli] Lapland Hosp Dist, Dept Psychiat, Rovaniemi, Finland.
   [Koivumaa-Honkanen, Heli] Univ Oulu, Dept Psychiat, Inst Clin Med, Oulu, Finland.
C3 Kuopio University Hospital; University of Eastern Finland; University of
   Eastern Finland Hospital; Paijat Hame Central Hospital; University of
   Eastern Finland; Tampere University; University of Eastern Finland;
   University of Oulu
RP Rissanen, T (corresponding author), Kuopio Univ Hosp, Dept Psychiat, POB 1777, FI-70211 Kuopio, Finland.
EM teemu.rissanen@fimnet.fi
RI Koivumaa-Honkanen, Heli/L-1274-2015
OI Lehto, Soili/0000-0003-4324-6679
FU EVO grant from Kuopio University Hospital
FX The authors thank Roy Siddall, Ph.D., for the language revision. This
   study was supported with an EVO grant from Kuopio University Hospital.
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NR 55
TC 12
Z9 13
U1 0
U2 13
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1471-244X
J9 BMC PSYCHIATRY
JI BMC Psychiatry
PD AUG 1
PY 2013
VL 13
AR 202
DI 10.1186/1471-244X-13-202
PG 8
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 195ZQ
UT WOS:000322743000001
PM 23902899
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Gramaglia, C
   Gambaro, E
   Bartolomei, G
   Camera, P
   Chiarelli-Serra, M
   Lorenzini, L
   Zeppegno, P
AF Gramaglia, Carla
   Gambaro, Eleonora
   Bartolomei, Giuseppe
   Camera, Paolo
   Chiarelli-Serra, Maira
   Lorenzini, Luca
   Zeppegno, Patrizia
TI Increased Risk of Metabolic Syndrome in Antidepressants Users: A Mini
   Review
SO FRONTIERS IN PSYCHIATRY
LA English
DT Review
DE metabolic syndrome; depression; antidepressants; cardiometabolic
   disease; review; preferred reporting items for systematic reviews and
   meta-analyses (PRISMA) statement
ID DEPRESSIVE SYMPTOMS; MAJOR DEPRESSION; SYNDROME ABNORMALITIES;
   INSULIN-RESISTANCE; MEDLINE SEARCHES; MENTAL-DISORDERS; ANXIETY;
   ASSOCIATION; OBESITY; HEALTH
AB Mounting evidence has shown that the risk of metabolic syndrome (MetS) is substantially overlapping in the diagnostic subgroups of psychiatric disorders. While it is widely acknowledged that patients receiving antipsychotic medications are at higher risk of MetS than antipsychotic-naive ones, the association between antidepressants and MetS is still debated. The goal of our mini review was to analyse the relationship among depressive symptoms, antidepressant use and the occurrence of MetS. Adhering to PRISMA guidelines, we searched MEDLINE, reference lists and journals, using the following search string: ((("Mental Disorders"[Mesh]) AND "Metabolic Syndrome"[Mesh]) AND "Antidepressive Agents"[Mesh]), and retrieved 36 records. Two reviewers independently assessed records and the mini review eventually included the data extracted from 8 studies. The Newcastle-Ottawa Scale was used to assess the quality of the selected studies. Overall, the results of the mini review seem to support the association among depressive symptoms, antidepressants therapy and MetS. Except for H1-R high-affinity ones, the relationship between antidepressants and MetS still needs to be clarified. Considering the widespread prescription of antidepressants, both on behalf of psychiatrists and primary care physicians, further research on this topic is recommended.
C1 [Gramaglia, Carla; Zeppegno, Patrizia] Univ Hosp Maggiore Carita, Psychiat Ward, Novara, Italy.
   [Gramaglia, Carla; Gambaro, Eleonora; Bartolomei, Giuseppe; Camera, Paolo; Chiarelli-Serra, Maira; Lorenzini, Luca; Zeppegno, Patrizia] Univ Piemonte Orientale, Inst Psychiat, Dept Translat Med, Novara, Italy.
C3 Azienda Ospedaliera Maggiore della Carita di Novara; University of
   Eastern Piedmont Amedeo Avogadro
RP Gramaglia, C (corresponding author), Univ Hosp Maggiore Carita, Psychiat Ward, Novara, Italy.; Gramaglia, C (corresponding author), Univ Piemonte Orientale, Inst Psychiat, Dept Translat Med, Novara, Italy.
EM carla.gramaglia@gmail.com
RI Ragazzoni, Luca/JWP-7327-2024; Zeppegno, Patrizia/F-8233-2013; Camera,
   Paolo/AAJ-2513-2020
OI , Luca/0000-0002-8255-7157; Bartolomei, Giuseppe/0000-0002-6372-8256;
   Camera, Paolo/0000-0002-2397-5113; eleonora, gambaro/0000-0001-9255-5967
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NR 62
TC 30
Z9 30
U1 1
U2 8
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-0640
J9 FRONT PSYCHIATRY
JI Front. Psychiatry
PD NOV 28
PY 2018
VL 9
AR 621
DI 10.3389/fpsyt.2018.00621
PG 9
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA HC2QU
UT WOS:000451647800001
PM 30546325
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Laugero, KD
   Falcon, LM
   Tucker, KL
AF Laugero, Kevin D.
   Falcon, Luis M.
   Tucker, Katherine L.
TI Relationship between perceived stress and dietary and activity patterns
   in older adults participating in the Boston Puerto Rican Health Study
SO APPETITE
LA English
DT Article
DE Psychological stress; Cortisol; Type 2 diabetes; Dietary patterns;
   Physical activity; Hispanic; Puerto Rican
ID FOOD FREQUENCY QUESTIONNAIRE; PITUITARY-ADRENAL AXIS; BODY-MASS INDEX;
   PHYSICAL-ACTIVITY; SOCIOECONOMIC-STATUS; METABOLIC SYNDROME; EATING
   BEHAVIOR; ADRENALECTOMIZED RATS; EXERCISE BEHAVIOR; HISPANIC ELDERS
AB Previous research supports a relationship between psychological stress and chronic disease in Puerto Rican adults living in the Boston, Massachusetts area. Stress may affect health by influencing dietary and physical activity patterns. Therefore, perceived stress and two hypothesized mediators of stress-related food intake, insulin and cortisol, were examined for possible associations with dietary and activity patterns in >1300 Puerto Ricans (aged 45-75 years; 70% women) living in the Boston, Massachusetts area. Data were analyzed using multiple linear regression and ANCOVA. Greater perceived stress was associated with lower fruit, vegetable, and protein intake, greater consumption of salty snacks, and lower participation in physical activity. Stress was associated with higher intake of sweets, particularly in those with type 2 diabetes. Cortisol and stress were positively associated in those without diabetes. Cortisol was associated with higher intake of saturated fat and, in those with diabetes, sweet foods. Independent of diabetes, perceived stress was associated with higher circulating insulin and BMI. Our findings support a link between stress, cortisol, and dietary and activity patterns in this population. For high-sugar foods, this relationship may be particularly important in those with type 2 diabetes. Longitudinal research to determine causal pathways for these identified associations is warranted. Published by Elsevier Ltd.
C1 [Laugero, Kevin D.] Univ Calif Davis, USDA, ARS, Western Human Nutr Res Ctr,Obes & Metab Res Unit, Davis, CA 95616 USA.
   [Laugero, Kevin D.] Univ Calif Davis, Dept Nutr, Davis, CA 95616 USA.
   [Falcon, Luis M.] Northeastern Univ, Dept Sociol & Anthropol, Boston, MA 02115 USA.
   [Tucker, Katherine L.] Northeastern Univ, Dept Hlth Sci, Boston, MA 02115 USA.
C3 University of California System; University of California Davis; United
   States Department of Agriculture (USDA); University of California
   System; University of California Davis; Northeastern University;
   Northeastern University
RP Laugero, KD (corresponding author), Univ Calif Davis, USDA, ARS, Western Human Nutr Res Ctr,Obes & Metab Res Unit, Davis, CA 95616 USA.
EM kevin.laugero@ars.usda.gov
RI Falcon, Luis/C-1237-2009; Tucker, Katherine/A-4545-2010
OI Falcon, Luis M./0000-0002-2476-5046; Tucker,
   Katherine/0000-0001-7640-662X
FU NIH [5P01-AG023394]; USDA-Agricultural Research Service CRIS
   [5306-51530-019-00D]; USDA-Agricultural Research Service [58-1950-7-707]
FX Supported by NIH 5P01-AG023394 and USDA-Agricultural Research Service
   CRIS# 5306-51530-019-00D and USDA-Agricultural Research Service
   agreement 58-1950-7-707.
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NR 96
TC 123
Z9 139
U1 3
U2 31
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 0195-6663
EI 1095-8304
J9 APPETITE
JI Appetite
PD FEB
PY 2011
VL 56
IS 1
BP 194
EP 204
DI 10.1016/j.appet.2010.11.001
PG 11
WC Behavioral Sciences; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Behavioral Sciences; Nutrition & Dietetics
GA 725BG
UT WOS:000287619600028
PM 21070827
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Kokkeler, KJE
   van den Berg, KS
   Comijs, HC
   Voshaar, RCO
   Marijnissen, RM
AF Kokkeler, Kitty J. E.
   van den Berg, Karen S.
   Comijs, Hannie C.
   Voshaar, Richard C. Oude
   Marijnissen, Radboud M.
TI Sarcopenic obesity predicts nonremission of late-life depression
SO INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
LA English
DT Article
DE abdominal obesity; depression; elderly; sarcopenia; sarcopenic obesity
ID METABOLIC SYNDROME; OLDER-ADULTS; WAIST CIRCUMFERENCE; NEUROTROPHIC
   FACTOR; BODY-COMPOSITION; NATIONAL-HEALTH; ASSOCIATION; SYMPTOMS;
   FRAILTY; PREVALENCE
AB Background/objectives Aging-related physiological changes like metabolic dysregulation and physical frailty are associated with depression and worsen its prognosis. Since central obesity is a key component of the metabolic syndrome and sarcopenia of physical frailty, we examined the association of sarcopenic obesity with depression cross-sectional and over time. Methods Cohort study of depressed patients and a nondepressed comparison group. Setting Primary and secondary mental health care. Participants Three hundred seventy-eight older (>= 60 y) depressed patients of which 285 were followed up at 2 years and 132 nondepressed persons participating in the Netherlands Study of Depression in Older (NESDO) persons. Measurements Sarcopenic obesity was based on predefined cutoffs for both maximum handgrip strength (assessed with a dynamometer) and waist circumference (dichotomous) as well as the product term of handgrip strength by waist circumference (dimensional). Depressive disorder according to DSM-IV-TR criteria was assessed with fully structured psychiatric interview at baseline and 2-year follow-up. Results Sarcopenic obesity was more prevalent among depressed patients compared with nondepressed participants (18.9% versus 10.7%, P = 0.030). Neither the dichotomous nor dimensional operationalization of sarcopenic obesity was associated with baseline depressive disorder when adjusted for covariates. Nonetheless, among depressed patients, logistic regression showed that the interaction of handgrip strength by waist circumference was associated with remitted depression at 2-year follow-up (P = 0.044). Only among patients with a low handgrip strength, a higher waist circumference predicted nonremission. Conclusion Among depressed patients, sarcopenic obesity predicts nonremission of depression. Therefore, combined exercise and nutritional interventions might be effective for depressed patients with sarcopenic obesity.
C1 [Kokkeler, Kitty J. E.; Marijnissen, Radboud M.] ProPersona, Dept Old Age Psychiat, Wolfheze 2, NL-6874 BE Wolfheze Ede, Netherlands.
   [Kokkeler, Kitty J. E.; van den Berg, Karen S.; Voshaar, Richard C. Oude; Marijnissen, Radboud M.] Univ Groningen, Univ Med Ctr Groningen, Univ Ctr Psychiat, Groningen, Netherlands.
   [Kokkeler, Kitty J. E.; van den Berg, Karen S.; Voshaar, Richard C. Oude; Marijnissen, Radboud M.] Univ Groningen, Univ Med Ctr Groningen, Interdisciplinary Ctr Psychopathol Emot Regulat, Groningen, Netherlands.
   [van den Berg, Karen S.] St Antonius Hosp, Dept Psychiat, Utrecht, Netherlands.
   [Comijs, Hannie C.] Vrije Univ Amsterdam, Dept Psychiat, Amsterdam Publ Hlth Res Inst, GGZinGeest,Med Ctr, Amsterdam, Netherlands.
C3 University of Groningen; University of Groningen; St. Antonius Hospital
   Utrecht; Vrije Universiteit Amsterdam
RP Kokkeler, KJE (corresponding author), ProPersona, Dept Old Age Psychiat, Wolfheze 2, NL-6874 BE Wolfheze Ede, Netherlands.
EM k.kokkeler@propersona.nl
OI van den Berg, Karen/0000-0001-6085-9552; Oude Voshaar,
   Richard/0000-0003-1501-4774
FU Fonds NutsOhra; National Alliance for Research on Schizophrenia and
   Depression; Stichting tot Steun Vereniging
FX Fonds NutsOhra; National Alliance for Research on Schizophrenia and
   Depression; Stichting tot Steun Vereniging tot Christelijke Verzorging
   van Geestes- en Zenuwzieken
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NR 57
TC 17
Z9 18
U1 0
U2 15
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0885-6230
EI 1099-1166
J9 INT J GERIATR PSYCH
JI Int. J. Geriatr. Psychiatr.
PD AUG
PY 2019
VL 34
IS 8
BP 1226
EP 1234
DI 10.1002/gps.5121
PG 9
WC Geriatrics & Gerontology; Gerontology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Psychiatry
GA IJ1LO
UT WOS:000475660200011
PM 30990918
OA Green Published
DA 2025-06-11
ER

PT J
AU Chae, WR
   Baumert, J
   Nübel, J
   Brasanac, J
   Gold, SM
   Hapke, U
   Otte, C
AF Chae, Woo Ri
   Baumert, Jens
   Nuebel, Julia
   Brasanac, Jelena
   Gold, Stefan M.
   Hapke, Ulfert
   Otte, Christian
TI Associations between individual depressive symptoms and immunometabolic
   characteristics in major depression
SO EUROPEAN NEUROPSYCHOPHARMACOLOGY
LA English
DT Article
DE Major depressive; Inflammation; Metabolic syndrome; Depressive symptoms;
   disorder
ID C-REACTIVE PROTEIN; RANDOMIZED CONTROLLED-TRIAL; GERMAN HEALTH
   INTERVIEW; ATYPICAL FEATURES; METABOLIC SYNDROME; SUICIDAL IDEATION;
   COMORBID OBESITY; LARGE COHORT; WEIGHT-LOSS; INFLAMMATION
AB Inflammation and metabolic dysregulations are likely to underlie atypical, energy-related de-pressive symptoms such as appetite and sleep alterations. Indeed, increased appetite was pre-viously identified as a core symptom of an immunometabolic subtype of depression. The aim of this study was 1) to replicate the associations between individual depressive symptoms and immunometabolic markers, 2) to extend previous findings with additional markers, and 3) to evaluate the relative contribution of these markers to depressive symptoms. We analyzed data from 266 persons with major depressive disorder (MDD) in the last 12 months from the German Health Interview and Examination Survey for Adults and its mental health module. Diagnosis of MDD and individual depressive symptoms were determined by the Composite International Di-agnostic Interview. Associations were analyzed using multivariable regression models, adjusting for depression severity, sociodemographic/behavioral variables, and medication use. Increased appetite was associated with higher body mass index (BMI), waist circumference (WC), insulin, and lower high-density lipoprotein. In contrast, decreased appetite was associated with lower BMI, WC, and fewer metabolic syndrome (MetS) components. Insomnia was associated with higher BMI, WC, number of MetS components, triglycerides, insulin, and lower albumin, while hypersomnia was associated with higher insulin. Suicidal ideation was associated with higher number of MetS components, glucose, and insulin. None of the symptoms were associated with C-reactive protein after adjustment. Appetite alterations and insomnia were most im-portant symptoms associated with metabolic markers. Longitudinal studies should investigate whether the candidate symptoms identified here are predicted by or predict the development of metabolic pathology in MDD.(c) 2023 Elsevier B.V. and ECNP. All rights reserved.
C1 [Chae, Woo Ri; Brasanac, Jelena; Gold, Stefan M.; Otte, Christian] Charite Univ Med Berlin, Dept Psychiat & Neurosci, Campus Benjamin Franklin,Hindenburgdamm 30, D-12203 Berlin, Germany.
   [Baumert, Jens; Nuebel, Julia; Hapke, Ulfert] Robert Koch Inst, Dept Epidemiol & Hlth Monitoring, Berlin, Germany.
   [Gold, Stefan M.] Charite Univ Med Berlin, Med Dept, Sect Psychosomat Med, Hindenburgdamm 30, D-12203 Berlin, Germany.
   [Gold, Stefan M.] Univ Med Ctr Hamburg Eppendorf, Inst Neuroimmunol & Multiple Sclerosis INIMS, Ctr Mol Neurobiol, Hamburg, Germany.
C3 Berlin Institute of Health; Free University of Berlin; Humboldt
   University of Berlin; Charite Universitatsmedizin Berlin; Robert Koch
   Institute; Berlin Institute of Health; Free University of Berlin;
   Humboldt University of Berlin; Charite Universitatsmedizin Berlin;
   University of Hamburg; University Medical Center Hamburg-Eppendorf
RP Chae, WR (corresponding author), Charite Univ Med Berlin, Dept Psychiat & Neurosci, Campus Benjamin Franklin,Hindenburgdamm 30, D-12203 Berlin, Germany.
EM woo-ri.chae@charite.de
RI Chae, Woo Ri/ACZ-9020-2022
OI Brasanac, Jelena/0000-0001-9786-7310; Gold, Stefan/0000-0001-5188-4799;
   Otte, Christian/0000-0002-4051-997X; Chae, Woo Ri/0000-0002-6326-8333
FU Federal Ministry of Health (Bundesministerium fur Gesundheit, BMG)
   [1368-1124, 1501-54401]; Technische Universitat Dresden; Foundation for
   Mental Health (Stiftung Seelische Gesundheit); German Center for
   Diabetes Research (Deutsches Zentrum fur Diabetesforschung, DZD) - the
   German Federal Ministry of Education and Research [HMGU2018Z3]
FX The conduction of DEGS1 and DEGS1-MH was funded by the Federal Ministry
   of Health (Bundesministerium fuer Gesundheit, BMG; grant numbers:
   1368-1124 and 1501-54401). Supplementary funding for DEGS1-MH was
   provided by the Technische Universitat Dresden, and by the Foundation
   for Mental Health (Stiftung Seelische Gesundheit) inaugurated by the
   German Association for Psychiatry, Psychotherapy, and Psychosomatics
   (Deutsche Gesellschaft fuer Psychiatrie und Psychotherapie,
   Psychosomatik und Nerven-heilkunde, DGPPN). Moreover, this work was
   supported by the German Center for Diabetes Research (Deutsches Zentrum
   fur Diabetesforschung, DZD), funded by the German Federal Ministry of
   Education and Research (grant number: HMGU2018Z3).
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NR 82
TC 15
Z9 16
U1 1
U2 6
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0924-977X
EI 1873-7862
J9 EUR NEUROPSYCHOPHARM
JI Eur. Neuropsychopharmacol.
PD JUN
PY 2023
VL 71
BP 25
EP 40
DI 10.1016/j.euroneuro.2023.03.007
EA MAR 2023
PG 16
WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA D1AO8
UT WOS:000966121400001
PM 36966710
DA 2025-06-11
ER

PT J
AU Açik, M
   Çakiroglu, FP
   Tekin, A
   Egeli, A
AF Acik, Murat
   Cakiroglu, Funda Pinar
   Tekin, Atilla
   Egeli, Asli
TI The effect of fish oil versus krill oil intervention on clinical
   symptoms and cardiometabolic risk factors in patients with major
   depressive disorder: A randomized placebo-controlled double-blind trial
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Depression; N-3 PUFAs; Anxiety; Distress; Metabolic risk factors
ID DOCOSAHEXAENOIC ACID; STRESS; SUPPLEMENTATION; OMEGA-3-FATTY-ACIDS;
   OVERWEIGHT; FORM
AB Background: This study aimed to compare the effects of krill- and fish-oil interventions on clinical symptoms and metabolic risk factors in individuals with MDD. Methods: In this randomized study, 57 adults diagnosed with MDD were allocated to receive krill-oil (520 mg EPA + DHA), fish-oil (600 mg EPA + DHA), or a placebo (soybean-oil) daily for 8 weeks. Anthropometric measurements, depression anxiety stress-21 (DASS-21) scale, and Hamilton depression rating scale (HDRS) were performed at baseline and 4 and 8 weeks. In addition, venous blood samples were collected at baseline and postintervention to evaluate lipid and glycemic profiles, including fasting glucose, HbA1c, cholesterol, triglycerides, LDL-c, and HDL-c levels.SPSS and R Studio software programs were used for statistical analysis. Results: A total of 50 participants completed the study, with 17 in each intervention group and 16 in the placebo. The mean HDRS scores decreased significantly in both the krill-oil (8.5 +/- 1.2) and fish-oil groups (10.0 +/- 1.2) compared to the placebo (p < 0.001), indicating clinical symptom improvement. Furthermore, the interaction effect of group-by-time was found to be statistically significant (eta 2p = 0.273;ptimexgroup < 0.001). Anxiety and distress scores decreased to similar levels after the post-intervention compared to baseline in krill- and fish-oil groups. Krill- and fish-oil supplementation increased plasma HDL-c and uric acid levels, but the group-by-time interaction effect was only observed at the HDL-c level (eta 2p = 0.238;ptimexgroup = 0.002). The mean HbA1c rates and plasma triglyceride levels of krill-oil recipients were lower after the post-intervention. Conclusion: Krill- and fish-oil could be considered as a safe and effective adjuvant treatments for depression. However, there was no evidence of apparent superiority over each other.
C1 [Acik, Murat] Firat Univ, Fac Hlth Sci, Dept Nutr & Dietet, Rectorate Campus, TR-23100 Elazig, Turkiye.
   [Cakiroglu, Funda Pinar] Ankara Univ, Fac Hlth Sci, Dept Nutr & Dietet, Ankara, Turkiye.
   [Tekin, Atilla] Adiyaman Univ, Fac Med, Dept Psychiat, Adiyaman, Turkiye.
   [Egeli, Asli] Tarsus State Hosp, Psychiat Clin, Mersin, Turkiye.
C3 Firat University; Ankara University; Adiyaman University
RP Açik, M (corresponding author), Firat Univ, Fac Hlth Sci, Dept Nutr & Dietet, Rectorate Campus, TR-23100 Elazig, Turkiye.
EM macik@firat.edu.tr
RI Çakıroğlu, Funda/G-6628-2016; Açık, Murat/ADR-4371-2022
OI Acik, Murat/0000-0002-3104-6306; PINAR CAKIROGLU,
   FUNDA/0000-0003-2324-6874
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NR 56
TC 0
Z9 0
U1 9
U2 9
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD JUL 1
PY 2025
VL 380
BP 171
EP 180
DI 10.1016/j.jad.2025.03.097
EA MAR 2025
PG 10
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA 0VX1M
UT WOS:001457277300001
PM 40118278
DA 2025-06-11
ER

PT J
AU Gragnoli, C
AF Gragnoli, Claudia
TI Depression and type 2 diabetes: Cortisol pathway implication and
   investigational needs
SO JOURNAL OF CELLULAR PHYSIOLOGY
LA English
DT Review
ID CORTICOTROPIN-RELEASING-FACTOR; PITUITARY-ADRENOCORTICAL AXIS;
   INSULIN-RESISTANCE; BIOCHEMICAL MANIFESTATIONS; HORMONE RECEPTOR-2;
   METABOLIC SYNDROME; GLUCOSE-PRODUCTION; MAJOR DEPRESSION;
   HEALTHY-SUBJECTS; MICE DEFICIENT
AB Depression and type 2 diabetes (T2D) are clinically associated and the causes of the association are still under investigation. We aimed at identifying what is known about the stress response and cortisol pathway and the clinical association of depression and T2D, and at hypothesizing the link of the association. In this review, we report independent studies on stress response, cortisol pathway, depression, T2D, and independent studies on stress and cortisol pathway in depression, and in T2D. We focus and integrate the stress and cortisol pathway hypothesis to explain the clinical association of depression and T2D. We hypothesize that the corticotropin-releasing hormone receptors are one of the missing linking factor of the cortisol pathway underlying the clinical association of depression and T2D. We state what studies are still needed to confirm or rule out our hypothesis. J. Cell. Physiol. 227: 23182322, 2012. (c) 2011 Wiley Periodicals, Inc.
C1 [Gragnoli, Claudia] Penn State Univ, Lab Mol Genet Complex & Monogen Disorders, Dept Med & Cellular & Mol Physiol & Biostat, Hershey, PA 17033 USA.
   [Gragnoli, Claudia] MS Hershey Med Ctr, Hershey, PA USA.
   [Gragnoli, Claudia] Bios Biotech Multidiagnost Hlth Ctr, Mol Biol Lab, Rome, Italy.
   [Gragnoli, Claudia] Temple Univ, Coll Sci & Technol, Ctr Biotechnol, Philadelphia, PA 19122 USA.
   [Gragnoli, Claudia] Temple Univ, Coll Sci & Technol, Dept Biol, Philadelphia, PA 19122 USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE);
   Pennsylvania State University; Penn State Health; Pennsylvania
   Commonwealth System of Higher Education (PCSHE); Pennsylvania State
   University; Penn State Health; Pennsylvania Commonwealth System of
   Higher Education (PCSHE); Temple University; Pennsylvania Commonwealth
   System of Higher Education (PCSHE); Temple University
RP Gragnoli, C (corresponding author), Penn State Milton S Hershey Med Ctr, Lab Mol Genet Complex & Monogen Disorders, Dept Med Cellular & Mol Physiol & Publ Hlth Sci, H044,500 Univ Dr, Hershey, PA 17033 USA.
EM claudia.gragnoli@gmail.com
RI Gragnoli, Claudia/ABA-4841-2020
FU Penn State College of Medicine
FX Contract grant sponsor: Penn State College of Medicine.
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NR 44
TC 26
Z9 28
U1 0
U2 26
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0021-9541
EI 1097-4652
J9 J CELL PHYSIOL
JI J. Cell. Physiol.
PD JUN
PY 2012
VL 227
IS 6
BP 2318
EP 2322
DI 10.1002/jcp.23012
PG 5
WC Cell Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Physiology
GA 898ES
UT WOS:000300719600004
PM 21898408
DA 2025-06-11
ER

PT J
AU Beijers, L
   Wardenaar, KJ
   Bosker, FJ
   Lamers, F
   van Grootheest, G
   de Boer, MK
   Penninx, BWJH
   Schoevers, RA
AF Beijers, Lian
   Wardenaar, Klaas J.
   Bosker, Fokko J.
   Lamers, Femke
   van Grootheest, Gerard
   de Boer, Marrit K.
   Penninx, Brenda W. J. H.
   Schoevers, Robert A.
TI Biomarker-based subtyping of depression and anxiety disorders using
   Latent Class Analysis. A NESDA study
SO PSYCHOLOGICAL MEDICINE
LA English
DT Article
DE Anxiety; biomarkers; depression; latent class analysis; subtyping
ID METABOLIC SYNDROME; PERSONALIZED MEDICINE; ANTIDEPRESSANT USE; MAJOR
   DEPRESSION; ADULT DEPRESSION; NETHERLANDS; OBESITY; HETEROGENEITY;
   METAANALYSIS; ASSOCIATION
AB Background Etiological research of depression and anxiety disorders has been hampered by diagnostic heterogeneity. In order to address this, researchers have tried to identify more homogeneous patient subgroups. This work has predominantly focused on explaining interpersonal heterogeneity based on clinical features (i.e. symptom profiles). However, to explain interpersonal variations in underlying pathophysiological mechanisms, it might be more effective to take biological heterogeneity as the point of departure when trying to identify subgroups. Therefore, this study aimed to identify data-driven subgroups of patients based on biomarker profiles. Methods Data of patients with a current depressive and/or anxiety disorder came from the Netherlands Study of Depression and Anxiety, a large, multi-site naturalistic cohort study (n = 1460). Thirty-six biomarkers (e.g. leptin, brain-derived neurotrophic factor, tryptophan) were measured, as well as sociodemographic and clinical characteristics. Latent class analysis of the discretized (lower 10%, middle, upper 10%) biomarkers were used to identify different patient clusters. Results The analyses resulted in three classes, which were primarily characterized by different levels of metabolic health: 'lean' (21.6%), 'average' (62.2%) and 'overweight' (16.2%). Inspection of the classes' clinical features showed the highest levels of psychopathology, severity and medication use in the overweight class. Conclusions The identified classes were strongly tied to general (metabolic) health, and did not reflect any natural cutoffs along the lines of the traditional diagnostic classifications. Our analyses suggested that especially poor metabolic health could be seen as a distal marker for depression and anxiety, suggesting a relationship between the 'overweight' subtype and internalizing psychopathology.
C1 [Beijers, Lian; Wardenaar, Klaas J.] Univ Groningen, Dept Psychiat, Univ Med Ctr Groningen, Interdisciplinary Ctr Psychopathol & Emot Regulat, Groningen, Netherlands.
   [Bosker, Fokko J.; de Boer, Marrit K.; Schoevers, Robert A.] Univ Groningen, Dept Psychiat, Univ Med Ctr Groningen, Groningen, Netherlands.
   [Lamers, Femke; van Grootheest, Gerard; Penninx, Brenda W. J. H.] GGZ inGeest, Amsterdam, Netherlands.
   [Lamers, Femke; van Grootheest, Gerard; Penninx, Brenda W. J. H.] Vrije Univ Amsterdam Med Ctr, Dept Psychiat, Amsterdam Publ Hlth Res Inst, Amsterdam, Netherlands.
C3 University of Groningen; University of Groningen; Vrije Universiteit
   Amsterdam; VU UNIVERSITY MEDICAL CENTER
RP Beijers, L (corresponding author), Univ Groningen, Dept Psychiat, Univ Med Ctr Groningen, Interdisciplinary Ctr Psychopathol & Emot Regulat, Groningen, Netherlands.
EM l.beijers@umcg.nl
RI Penninx, Brenda/S-7627-2017; Lamers, Femke/G-5161-2012; van Grootheest,
   Gerard/C-6942-2014; Wardenaar, Klaas/E-2985-2013
OI Schoevers, Robert A/0000-0003-0760-9866
FU European Union [PCIG12-GA-2012-334065]
FX Dr. Lamers has received funding from the European Union Seventh
   Framework Programme (FP7/2007-2013) under grant agreement no
   PCIG12-GA-2012-334065.
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NR 75
TC 27
Z9 27
U1 3
U2 20
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
SN 0033-2917
EI 1469-8978
J9 PSYCHOL MED
JI Psychol. Med.
PD MAR
PY 2019
VL 49
IS 4
BP 617
EP 627
DI 10.1017/S0033291718001307
PG 11
WC Psychology, Clinical; Psychiatry; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA HL5FX
UT WOS:000458753100010
PM 29860945
OA Green Submitted, Green Published, hybrid
DA 2025-06-11
ER

PT J
AU van Dammen, L
   Bush, NR
   de Rooij, SR
   Mol, BWJ
   Groen, H
   Hoek, A
   Roseboom, TJ
AF van Dammen, Lotte
   Bush, Nicole R.
   de Rooij, Susanne R.
   Mol, Ben Willem J.
   Groen, Henk
   Hoek, Annemieke
   Roseboom, Tessa J.
TI Childhood adversity and women's cardiometabolic health in adulthood:
   associations with health behaviors, psychological distress, mood
   symptoms, and personality
SO BMC WOMENS HEALTH
LA English
DT Article
DE Childhood adversity; Cardiometabolic health; Health behaviors;
   Personality; Mental wellbeing
ID EARLY-LIFE ADVERSITY; CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME;
   PERCEIVED STRESS; HOSPITAL ANXIETY; PHYSICAL HEALTH; EATING BEHAVIOR;
   YOUNG-ADULTS; EXPERIENCES; DEPRESSION
AB BackgroundWe tested whether childhood adversity is associated with poor cardiometabolic health in adulthood among a sample of overweight or obese Dutch women of reproductive age. Health behaviors, psychological distress, mood symptoms, or personality traits were included as potential mediators.MethodsData came from a follow-up visit (N=115), carried out in 2016/2017, of a randomized controlled lifestyle intervention trial in 577 obese infertile women. The associations between total adversity exposure score and cardiometabolic health were tested with regression models. Sleep, smoking and eating behavior, symptoms of depression, anxiety and stress, and personality traits were potential mediators.ResultsChildhood adversity scores were not associated with cardiometabolic outcomes but were associated with poorer sleep quality score (M=7.2 (SD=3.5) for those with >= 2 types of events versus 4.8 (2.9) for those with no events; p=0.022), higher external eating score (26.4 (8.7) versus 21.8 (10.3); p=0.038), higher perceived stress score (17.1 (6.8) versus 12.3 (4.5); p=0.016), post-traumatic stress score (1.9 (1.5) versus 0.6 (1.1); p<0.001), and lower agreeableness score (28.2 (4.2) versus 30.3 (3.1); p=0.035).ConclusionChildhood adversity was associated with poorer health behaviors including sleep and eating behavior, and more stress-related symptoms, but not with women's cardiometabolic health.
C1 [van Dammen, Lotte] Iowa State Univ, Dept Human Dev & Family Studies, Ames, IA 50011 USA.
   [van Dammen, Lotte; Hoek, Annemieke] Univ Groningen, Univ Med Ctr Groningen, Dept Obstet, Groningen, Netherlands.
   [van Dammen, Lotte; Hoek, Annemieke] Univ Groningen, Univ Med Ctr Groningen, Dept Gynaecol, Groningen, Netherlands.
   [van Dammen, Lotte; Groen, Henk] Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, Groningen, Netherlands.
   [Bush, Nicole R.] Univ Calif San Francisco, Dept Psychiat, San Francisco, CA 94143 USA.
   [Bush, Nicole R.] Univ Calif San Francisco, Dept Pediat, San Francisco, CA 94143 USA.
   [Bush, Nicole R.] Ctr Hlth & Community, Div Dev Med, San Francisco, CA USA.
   [de Rooij, Susanne R.; Roseboom, Tessa J.] Univ Amsterdam, Amsterdam UMC, Dept Clin Epidemiol, Amsterdam, Netherlands.
   [de Rooij, Susanne R.; Roseboom, Tessa J.] Univ Amsterdam, Amsterdam UMC, Dept Biostat & Bioinformat, Amsterdam, Netherlands.
   [Roseboom, Tessa J.] Univ Amsterdam, Amsterdam UMC, Obstet & Gynaecol, Amsterdam, Netherlands.
   [Mol, Ben Willem J.] Monash Univ, Dept Obstet & Gynaecol, Clayton, Vic, Australia.
C3 Iowa State University; University of Groningen; University of Groningen;
   University of Groningen; University of California System; University of
   California San Francisco; University of California System; University of
   California San Francisco; University of Amsterdam; University of
   Amsterdam; University of Amsterdam; Monash University
RP van Dammen, L (corresponding author), Iowa State Univ, Dept Human Dev & Family Studies, Ames, IA 50011 USA.; van Dammen, L (corresponding author), Univ Groningen, Univ Med Ctr Groningen, Dept Obstet, Groningen, Netherlands.; van Dammen, L (corresponding author), Univ Groningen, Univ Med Ctr Groningen, Dept Gynaecol, Groningen, Netherlands.
EM lotte@iastate.edu
RI Mol, Ben/I-4526-2012; van Dammen, Lotte/ABD-4674-2021; Bush,
   Nicole/AAH-4935-2020; Groen, Henk/B-2163-2013
OI Roseboom, Tessa/0000-0003-0564-5994; Groen, Henk/0000-0002-6629-318X;
   Mol, Ben Willem/0000-0001-8337-550X; van Dammen,
   Lotte/0000-0001-8012-8263; de Rooij, Susanne Rosalie/0000-0001-7382-5749
FU Netherlands Organization for Health Research and Development
   [50-50110-96-518]; Dutch Heart Foundation [2013 T085]; European
   Commission (Horizon2020 project 'DynaHealth') [633595]
FX This research was supported by The Netherlands Organization for Health
   Research and Development (50-50110-96-518), the Dutch Heart Foundation
   (Grant number: 2013 T085), and the European Commission (Horizon2020
   project 'DynaHealth', 633595). The department of obstetrics and
   gynaecology from the UMCG received an unrestricted educational grant
   from Ferring Pharmaceutical BV the Netherlands, unrelated to the present
   study.
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NR 61
TC 5
Z9 6
U1 1
U2 9
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1472-6874
J9 BMC WOMENS HEALTH
JI BMC Womens Health
PD JUL 23
PY 2019
VL 19
AR 102
DI 10.1186/s12905-019-0797-z
PG 10
WC Public, Environmental & Occupational Health; Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; Obstetrics & Gynecology
GA IL1HF
UT WOS:000477049600001
PM 31337378
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Weaver, LJ
   Worthman, CM
   DeCaro, JA
   Madhu, SV
AF Weaver, Lesley Jo
   Worthman, Carol M.
   DeCaro, Jason A.
   Madhu, S. V.
TI The signs of stress: Embodiments of biosocial stress among type 2
   diabetic women in New Delhi, India
SO SOCIAL SCIENCE & MEDICINE
LA English
DT Article
DE India; Type 2 diabetes; Mental health; Biocultural anthropology; Mixed
   methods
ID C-REACTIVE PROTEIN; EPSTEIN-BARR-VIRUS; URBAN-RURAL EPIDEMIOLOGY;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; IMMUNE FUNCTION; LIFE-STYLE;
   DEPRESSION; HEALTH; ASSOCIATION
AB Biocultural models of health and illness are increasingly used to trace how social pathways shape biological outcomes. Yet, data on the interactions between social and biological aspects of health are lacking in low- and middle-income regions, where two-thirds of all type 2 diabetes cases occur. This study explored health, social roles, and biological correlates among a group of 280 type 2 diabetic and nondiabetic women (n = 184 diabetic) in New Delhi, India, between 2009 and 2011. Using a biocultural framework, we developed and tested a series of hypotheses about the relationships that might exist between diabetes, psychological distress, social role fulfillment, and biological markers measuring blood sugar control, generalized inflammation, and immune stress. Although blood glucose and glycated hemoglobin levels indicated that women's diabetes was generally poorly controlled, they lacked the elevated inflammation, immune stress, and mental ill health that often accompany uncontrolled blood sugar. Qualitative work on explanatory models of diabetes and gendered models of appropriate behavior demonstrated that despite living with poorly controlled diabetes, women maintain participation in culturally valued roles involving the care of others. We suggest that behavioral congruence with these gendered roles may buffer diabetic women's mental health and perhaps even their long-term physical health, while simultaneously posing challenges for their diabetes self-care. To our knowledge, this is the first study to explore the experience of type 2 diabetes in India from an integrated biocultural perspective. (C) 2015 Elsevier Ltd. All rights reserved.
C1 [Weaver, Lesley Jo; DeCaro, Jason A.] Univ Alabama, Tuscaloosa, AL 35487 USA.
   [Worthman, Carol M.] Emory Univ, Atlanta, GA 30322 USA.
   [Madhu, S. V.] Univ Coll Med Sci, New Delhi, India.
C3 University of Alabama System; University of Alabama Tuscaloosa; Emory
   University; University of Delhi; University College of Medical Sciences
RP Weaver, LJ (corresponding author), Univ Alabama, Tuscaloosa, AL 35487 USA.
EM ljweaver@ua.edu
RI Madhu, S/AAH-7431-2019
OI DeCaro, Jason/0000-0002-3333-212X; Worthman, Carol M/0000-0002-5397-2298
FU National Science Foundation [P022A0100030]; Fulbright Hays Foundation;
   Lemelson/SPA fund; Emory University Department of Anthropology
FX This research was supported by grants from the National Science
   Foundation (P022A0100030), the Fulbright Hays Foundation, the
   Lemelson/SPA fund, and Emory University Department of Anthropology. The
   authors wish to thank member physicians of the Research Society for the
   Study of Diabetes in India, and all participants in the study.
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   [No title captured]
NR 59
TC 33
Z9 37
U1 1
U2 30
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0277-9536
J9 SOC SCI MED
JI Soc. Sci. Med.
PD APR
PY 2015
VL 131
BP 122
EP 130
DI 10.1016/j.socscimed.2015.03.002
PG 9
WC Public, Environmental & Occupational Health; Social Sciences, Biomedical
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; Biomedical Social Sciences
GA CF1SE
UT WOS:000352327400015
PM 25771481
DA 2025-06-11
ER

PT J
AU Ahmed, M
   Hussain, I
   O'Brien, SM
   Dineen, B
   Griffin, D
   McDonald, C
AF Ahmed, M.
   Hussain, I.
   O'Brien, S. M.
   Dineen, B.
   Griffin, D.
   McDonald, C.
TI Prevalence and associations of the metabolic syndrome among patients
   prescribed clozapine
SO IRISH JOURNAL OF MEDICAL SCIENCE
LA English
DT Article
DE atypical antipsychotics; clozapine; metabolic syndrome; physical illness
ID MIDDLE-AGED MEN; CARDIOVASCULAR-DISEASE; SCHIZOPHRENIA; ANTIPSYCHOTICS;
   METAANALYSIS; MORTALITY; HEALTH
AB Background There is increasing concern that the use of second-generation antipsychotic medications in schizophrenia is associated with the development of metabolic syndrome.
   Aims This study assessed the prevalence and clinical associations of metabolic syndrome among patients receiving clozapine within the catchment area of a mental health service in the west of Ireland.
   Method A total of 84 patients (96% response rate) taking clozapine were interviewed and thoroughly investigated using physical assessments, comprehensive laboratory testing and review of medical records.
   Results Of the patients, 46.4% taking clozapine fulfilled the criteria for metabolic syndrome. Male gender, high body mass index, high insulin level and receiving a concomitant antipsychotic medication were significantly associated with the presence of metabolic syndrome.
   Conclusion Almost half of the patients receiving clozapine have metabolic syndrome and are consequently at risk of cardiovascular morbidity and mortality. Such patients should be closely monitored in order to facilitate interventions, which could alleviate the adverse health consequences of this syndrome.
C1 [Ahmed, M.] Natl Univ Ireland Univ Coll Galway, Dept Psychiat, Inst Clin Sci, Galway, Ireland.
   [Dineen, B.] Natl Univ Ireland Univ Coll Galway, Dept Gen Practice, Galway, Ireland.
   [Griffin, D.] Univ Coll Hosp Galway, Dept Clin Biochem, Galway, Ireland.
C3 Ollscoil na Gaillimhe-University of Galway; Ollscoil na
   Gaillimhe-University of Galway; Ollscoil na Gaillimhe-University of
   Galway
RP Ahmed, M (corresponding author), Natl Univ Ireland Univ Coll Galway, Dept Psychiat, Inst Clin Sci, Galway, Ireland.
EM mohamed.ahmed@nuigalway.ie
RI Griffin, Daniel/AAE-8381-2021; McDonald, Colm/C-1430-2009
OI Dineen, Brendan/0000-0002-9619-8044
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NR 27
TC 22
Z9 23
U1 0
U2 3
PU SPRINGER LONDON LTD
PI LONDON
PA 236 GRAYS INN RD, 6TH FLOOR, LONDON WC1X 8HL, ENGLAND
SN 0021-1265
EI 1863-4362
J9 IRISH J MED SCI
JI Irish J. Med. Sci.
PD SEP
PY 2008
VL 177
IS 3
BP 205
EP 210
DI 10.1007/s11845-008-0156-9
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 332DY
UT WOS:000258063500005
PM 18461270
DA 2025-06-11
ER

PT J
AU Yehuda, S
   Rabinovitz, S
   Mostofsky, DI
AF Yehuda, S.
   Rabinovitz, S.
   Mostofsky, D. I.
TI Mediation of cognitive function by high fat diet following stress and
   inflammation
SO NUTRITIONAL NEUROSCIENCE
LA English
DT Article
DE high fat diet; omega-3; fatty acids; PUFA; stress; inflammation brain
   chemistry
ID T-LYMPHOCYTE PROLIFERATION; TUMOR-NECROSIS-FACTOR; DOCOSAHEXAENOIC ACID;
   PSYCHOLOGICAL STRESS; DELTA-5 DESATURATION; BRAIN BIOCHEMISTRY;
   METABOLIC SYNDROME; DIABETES-MELLITUS; IRON-DEFICIENCY; FISH-OIL
AB In addition to commonly advertised hazards of obesity contributed by excess dietary fat, evidence of alterations in brain chemistry and structure are well documented. This brief review examines the role of nutrients, minerals and certain lipids, primarily the essential fatty acids (FA), that are beneficial to the maintenance of good health and that may offer therapeutic options by dietary supplementation. The review also considers the damaging effects of stress, especially in pre-existing conditions of obesity and diabetes, as studied in both animals and humans. The main focus of this brief review is to examine the effects of a high fat diet on stress and the immune system with particular emphasis on brain and cognitive function.
C1 Bar Ilan Univ, Dept Psychol, Psychopharmacol Lab, IL-52900 Ramat Gan, Israel.
   Bar Ilan Univ, Brain Res Inst, IL-52900 Ramat Gan, Israel.
   Boston Univ, Dept Psychol, Boston, MA 02215 USA.
C3 Bar Ilan University; Bar Ilan University; Boston University
RP Yehuda, S (corresponding author), Bar Ilan Univ, Dept Psychol, Psychopharmacol Lab, IL-52900 Ramat Gan, Israel.
EM yehudas@mail.biu.ac.il
OI Mostofsky, David/0000-0003-2654-8376
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NR 77
TC 18
Z9 23
U1 0
U2 15
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1028-415X
EI 1476-8305
J9 NUTR NEUROSCI
JI Nutr. Neurosci.
PD OCT-DEC
PY 2005
VL 8
IS 5-6
BP 309
EP 315
DI 10.1080/00268970500509972
PG 7
WC Neurosciences; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Nutrition & Dietetics
GA 043UV
UT WOS:000237628600005
PM 16669601
DA 2025-06-11
ER

PT J
AU Min, SH
   Yang, Q
   Min, SW
   Ledbetter, L
   Docherty, SL
   Im, EO
   Rushton, S
AF Min, Se Hee
   Yang, Qing
   Min, Se Won
   Ledbetter, Leila
   Docherty, Sharron L.
   Im, Eun-Ok
   Rushton, Sharron
TI Are there differences in symptoms experienced by midlife climacteric
   women with and without metabolic syndrome? A scoping review
SO WOMENS HEALTH
LA English
DT Review
DE menopause; midlife; symptoms; Syndrome X; women's health
ID QUALITY-OF-LIFE; POSTMENOPAUSAL WOMEN; MENOPAUSAL SYMPTOMS; VASOMOTOR
   SYMPTOMS; SEXUAL FUNCTION; HEALTH; PREVALENCE; ASSOCIATION; DEPRESSION;
   MANAGEMENT
AB Introduction: Midlife climacteric women with metabolic syndrome are at high risk for experiencing a complex array of symptoms. The aim of this scoping review was to identify the prevalence, types, and clustering of symptoms in midlife climacteric women with metabolic syndrome and to compare them to symptoms of midlife climacteric women without metabolic syndrome.
   Methods: A three-step search method was used according to Joanna Briggs Institute methodology. Eligibility criteria of participants, concept, context, and types of evidence were selected in alignment with the review questions. Seven databases (PubMed, Embase, Web of Science, CINAHL, PsycINFO, ProQuest Dissertation & Theses, OpenGrey) were searched using search terms with no language or date restrictions. Title and abstract screening, full-text review, data charting, and data synthesis were conducted by two independent researchers based on the eligibility criteria.
   Results: The search yielded 3813 studies after removing duplicates with 48 full-text papers assessed for eligibility. A total of eight studies were reviewed and analyzed which reported the prevalence and types of symptoms individually or grouped based on each body system. Midlife climacteric women with metabolic syndrome experience a wide prevalence of individual and grouped urogenital, vasomotor, psychological, sleep, and somatic symptoms. Mental exhaustion had the highest prevalence (84.4%) among the individual symptoms, and urogenital symptoms had the highest prevalence (81.3%) among the grouped symptoms. There were mixed findings on symptoms between midlife climacteric women with metabolic syndrome and without metabolic syndrome. No studies focused on symptom clusters.
   Conclusion: Our findings will serve as a knowledge basis for understanding symptoms experienced by midlife climacteric women with metabolic syndrome. This new knowledge can assist clinicians in effectively assessing and managing their symptoms in clinical settings and inform future development of targeted symptom management interventions.
C1 [Min, Se Hee; Yang, Qing; Ledbetter, Leila; Docherty, Sharron L.; Rushton, Sharron] Duke Univ, Sch Nursing, 307 Trent Dr, Durham, NC 27710 USA.
   [Min, Se Won] Univ Washington, Sch Nursing, Seattle, WA 98195 USA.
   [Im, Eun-Ok] Emory Univ, Sch Nursing, Atlanta, GA 30322 USA.
C3 Duke University; University of Washington; University of Washington
   Seattle; Emory University
RP Min, SH (corresponding author), Duke Univ, Sch Nursing, 307 Trent Dr, Durham, NC 27710 USA.
EM sehee.min@duke.edu
RI ; Ledbetter, Leila/N-9513-2014
OI Yang, Qing/0000-0003-4844-4690; Min, Se Hee/0000-0003-2722-6627;
   Ledbetter, Leila/0000-0002-5206-8002
FU National Institute of Nursing Research of the National Institutes of
   Health [1F31NR019921-01]
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: Research
   reported in this publication was supported by the National Institute of
   Nursing Research of the National Institutes of Health under Award Number
   1F31NR019921-01. The content is solely the responsibility of the authors
   and does not necessarily represent the official views of the National
   Institutes of Health.
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NR 54
TC 3
Z9 4
U1 1
U2 6
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1745-5057
EI 1745-5065
J9 WOMENS HEALTH
JI Womens Health
PD MAR
PY 2022
VL 18
AR 17455057221083817
DI 10.1177/17455057221083817
PG 17
WC Obstetrics & Gynecology
WE Emerging Sources Citation Index (ESCI)
SC Obstetrics & Gynecology
GA ZW5GU
UT WOS:000771242000001
PM 35266423
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Musso, G
   Gambino, R
   Bo, S
   Uberti, B
   Biroli, G
   Pagano, G
   Cassader, M
AF Musso, Giovanni
   Gambino, Roberto
   Bo, Simona
   Uberti, Barbara
   Biroli, Giampaolo
   Pagano, Gianfranco
   Cassader, Maurizio
TI Should nonalcoholic fatty liver disease be included in the definition of
   metabolic syndrome - A cross-sectional comparison with Adult Treatment
   Panel III criteria in nonobese nondiabetic subjects
SO DIABETES CARE
LA English
DT Article
ID HOMEOSTASIS MODEL ASSESSMENT; C-REACTIVE PROTEIN; INSULIN-RESISTANCE;
   ALANINE AMINOTRANSFERASE; CARDIOVASCULAR-DISEASE; GLUCOSE-TOLERANCE;
   RISK; PREDICTS; STEATOHEPATITIS; ASSOCIATION
AB OBJECTIVE - The ability of the Adult Treatment Panel III (ATP III) criteria of metabolic syndrome to identify insulin-resistant subjects at increased cardiovascular risk is suboptimal, especially in the absence of obesity and diabetes. Nonalcoholic fatty liver disease (NAFLD) is associated with insulin resistance and is emerging as an independent cardiovascular risk factor. We compared the strength Of the associations of ATP III criteria and of NAFLD to insulin resistance, oxidative stress, and endothelial dysfunction in nonobese nondiabetic subjects.
   RESEARCH DESIGN AND METHODS - Homeostasis model assessment of insulin resistance (HOMA-IR) > 2, oxidative stress (nitrotyrosine), soluble adhesion molecules (intracellular adhesion molecule-1, vascular cell adhesion molecule-1, and E-selectin), and circulating adipokines (tumor necrosis factor-a, leptin, adiponectin, and resistin) were cross-sectionally correlated to ATP III criteria and to NAFLD in 197 unselected nonobese nondiabetic subjects.
   RESULTS - NAFLD more accurately predicted insulin resistance than ATP III criteria: sensitivity 73 vs. 38% (P = 0.0001); positive predictive value: 81 vs. 62% (P = 0.035); negative predictive value 87 vs. 74% (P = 0.012); positive likelihood ratio 4.39 vs. 1.64 (P = 0.0001); and negative likelihood ratio 0.14 vs. 0.35 (P = 0.0001). Adding NAFLD to ATP III criteria significantly improved their diagnostic accuracy for insulin resistance. Furthermore, NAFLD independently predicted HOMA-IR, nitrotyrosine, and soluble adhesion molecules on logistic regression analysis; the presence of NAFLD entailed more severe oxidative stress and enclothelial dysfunction, independent of adiposity or any feature of the metabolic syndrome in insulin-resistant subjects.
   CONCLUSIONS - NAFLD is more tightly associated with insulin resistance and with markers of oxidative stress and endothelial dysfunction than with ATP III criteria in nonobese nondiabetic subjects and may help identify individuals with increased cardiometabolic risk in this population.
C1 [Musso, Giovanni] Gradenigo Hosp, I-10132 Turin, Italy.
   [Gambino, Roberto; Bo, Simona; Uberti, Barbara; Biroli, Giampaolo; Pagano, Gianfranco; Cassader, Maurizio] Univ Turin, Dept Internal Med, Turin, Italy.
C3 Humanitas Hospital Gradenigo; University of Turin
RP Musso, G (corresponding author), Gradenigo Hosp, Corso R Margherita 8, I-10132 Turin, Italy.
EM giovanni_musso@yahoo.it
RI GAMBINO, Roberto/AAC-7517-2022; Bo, Simona/AAC-1110-2019; Musso,
   Giovanni/AAB-7884-2022
OI Bo, Simona/0000-0001-6862-8628
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NR 31
TC 160
Z9 177
U1 0
U2 5
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0149-5992
EI 1935-5548
J9 DIABETES CARE
JI Diabetes Care
PD MAR
PY 2008
VL 31
IS 3
BP 562
EP 568
DI 10.2337/dc07-1526
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 271PL
UT WOS:000253801100040
PM 18056890
OA Bronze
DA 2025-06-11
ER

PT J
AU Miguel, ED
   Lopes, SO
   Araújo, SP
   Priore, SE
   Alfenas, RDG
   Hermsdorff, HHM
AF Miguel, Elizangela da Silva
   Lopes, Silvia Oliveira
   Araujo, Susilane Pereira
   Priore, Silvia Eloiza
   Goncalves Alfenas, Rita de Cassia
   Miranda Hermsdorff, Helen Hermana
TI Association between food insecurity and cardiometabolic risk in adults
   and the elderly: A systematic review
SO JOURNAL OF GLOBAL HEALTH
LA English
DT Review
ID NUTRITION; INDICATORS; AMERICA; WOMEN
AB Background Food insecurity is a public health concern that affects health and quality of life, but its association with cardiometabolic risk is not well established. Thus, this systematic review evaluated the association between food insecurity and cardiometabolic risk factors in adults and the elderly.
   Methods Search was conducted according to the PRISMA protocol using Scielo, LILACS and PubMed databases. We included original articles published in Portuguese, English, and Spanish, which assessed the association between food insecurity and cardiometabolic risk factors in adults and the elderly. The search identified 877 articles but only 11 were included in the review.
   Results Food insecurity was directly associated with cardiometabolic risk (excess weight, hypertension, dyslipidemias, diabetes, and stress) after adjusting for interfering factors. A limitation of the cross-sectional study design is that the cause-effect relation between food insecurity and cardiometabolic risk cannot be established.
   Conclusions We conclude that food insecurity has a direct relationship with cardiometabolic risk factors, especially excess weight, hypertension, and dyslipidemias. The identification of food insecurity as health problems can contribute to the implementation of efficient public policies for the prevention and control of chronic diseases.
C1 [Miguel, Elizangela da Silva; Lopes, Silvia Oliveira; Araujo, Susilane Pereira; Priore, Silvia Eloiza; Goncalves Alfenas, Rita de Cassia; Miranda Hermsdorff, Helen Hermana] Univ Fed Vicosa, Dept Nutr & Hlth, Av Ph Rolfs S-N,Campus UFV, BR-36570900 Vicosa, MG, Brazil.
C3 Universidade Federal de Vicosa
RP Hermsdorff, HHM (corresponding author), Univ Fed Vicosa, Dept Nutr & Hlth, Av Ph Rolfs S-N,Campus UFV, BR-36570900 Vicosa, MG, Brazil.
EM helenhermana@ufv.br
OI Alfenas, Rita/0000-0003-2290-1611; Miguel,
   Elizangela/0000-0002-2434-5068
FU CAPES Foundation (Ministry of Education, Brazil) [001]; Minas Gerais
   State Research Foundation (FAPEMIG, State of Minas Gerais, Brazil);
   National Council for Scientific and Technological Development (CNPq,
   Ministry of Science and Technology, Brazil)
FX We thank CAPES Foundation (Ministry of Education, Brazil, Financial Code
   001), Minas Gerais State Research Foundation (FAPEMIG, State of Minas
   Gerais, Brazil), and the National Council for Scientific and
   Technological Development (CNPq, Ministry of Science and Technology,
   Brazil) for supporting the related projects.
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NR 38
TC 25
Z9 26
U1 1
U2 6
PU INT SOC GLOBAL HEALTH
PI EDINBURGH
PA CALEDONIAN EXCHANGE, 19A CANNING ST, EDINBURGH, ENGLAND
SN 2047-2978
EI 2047-2986
J9 J GLOB HEALTH
JI J. Glob. Health
PD DEC
PY 2020
VL 10
IS 2
AR 020402
DI 10.7189/jogh.10.020402
PG 7
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA PZ1CH
UT WOS:000612476300115
PM 33110569
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Chiang, LC
   Chiang, SL
   Tzeng, WC
   Lee, MS
   Hung, YJ
   Lin, CH
AF Chiang, Li-Chi
   Chiang, Shang-Lin
   Tzeng, Wen-Chii
   Lee, Meei-Shyuan
   Hung, Yi-Jen
   Lin, Chia-Huei
TI Active Physical Activity Patterns Are Associated With Improved Quality
   of Life and Depression Status in Taiwanese Women With Metabolic Syndrome
SO JOURNAL OF CARDIOVASCULAR NURSING
LA English
DT Article
DE depression status; health-related quality of life; metabolic syndrome;
   physical activity; women's health
ID NUTRITION EXAMINATION SURVEY; NATIONAL-HEALTH; RISK-FACTORS;
   METAANALYSIS; PREVALENCE; ADULTS; INVENTORY; BEHAVIOR
AB Background: Metabolic syndrome (MetS), health-related quality of life (HRQL), and depression status are independently associated with cardiac health. Therefore, understanding the associations between MetS, HRQL, and depression status and determining factors related to improved HRQL and depression status in people with MetS may help in cardiovascular disease prevention. Objective: The aim of this study was to examine whether there are differences in HRQL and depression status between Taiwanese women with and without MetS and whether physical activity patterns are associated with HRQL and depression status in this population. Methods: A cross-sectional study of 326 Taiwanese middle-aged and older women (>= 40 years) was conducted. Metabolic syndrome was determined based on the National Cholesterol Education Program Adult Treatment Panel III definition. Health-related quality of life and depression status were collected using the Short Form 36 Health Survey and Beck Depression Inventory. Univariate and multivariate linear regression analyses were conducted. Results: Women with MetS had lower HRQL (P < .001) and higher depression status (P = .002) than those without MetS. Participants with active physical activity patterns had higher HRQL (P < .001) and lower depression status (P = .046) than those with sedentary patterns. Among women with MetS, those with active physical activity patterns had higher HRQL (P = .001) and lower depression status (P = .007) than those with sedentary patterns. Conclusions: Metabolic syndrome is related to lower HRQL and higher depression status in women 40 years and older. Active physical activity patterns are associated with better HRQL and reduced depression status in middle-aged and older women (>= 40 years) with MetS.
C1 [Chiang, Li-Chi; Tzeng, Wen-Chii; Lin, Chia-Huei] Natl Def Med Ctr, Sch Nursing, Taipei, Taiwan.
   [Chiang, Li-Chi] China Med Univ, Sch Nursing, Taichung, Taiwan.
   [Chiang, Shang-Lin; Hung, Yi-Jen; Lin, Chia-Huei] Natl Def Med Ctr, Sch Med, Taipei, Taiwan.
   [Chiang, Shang-Lin] Triserv Gen Hosp, Dept Phys Med & Rehabil, Taipei, Taiwan.
   [Lee, Meei-Shyuan] Natl Def Med Ctr, Sch Publ Hlth, Taipei, Taiwan.
   [Lee, Meei-Shyuan] Natl Def Med Ctr, Grad Inst Med Sci, Taipei, Taiwan.
   [Hung, Yi-Jen] Triserv Gen Hosp, Songshan Branch, Taipei, Taiwan.
   [Lin, Chia-Huei] Triserv Gen Hosp, Songshan Branch, Dept Nursing, Taipei, Taiwan.
C3 National Defense Medical Center; China Medical University Taiwan;
   National Defense Medical Center; Tri-Service General Hospital; National
   Defense Medical Center; National Defense Medical Center; Tri-Service
   General Hospital; Tri-Service General Hospital
RP Lin, CH (corresponding author), Natl Def Med Ctr, 161 Sec 6 Mingchuan E Rd,Neihu 114 Dist, Taipei 10114, Taiwan.
EM andyy520@mail.ndmctsgh.edu.tw
RI Lin, Chia-Huei/GLQ-5499-2022; Tzeng, Wen-Chii/M-4214-2014; Chiang,
   Li-Chi/AAW-9661-2020
OI Tzeng, Wen-Chii/0000-0002-4205-896X; Lin, Chia-Huei/0000-0002-5557-9668;
   Chiang, Li-Chi/0000-0002-6383-7495; Lin, Chia-Huei/0000-0003-3751-602X
FU Tri-Service General Hospital, Taipei, Taiwan [TSGH-100-05-193,
   MOST107-2314-B016-068]
FX Assistant Professor, Schools of Nursing and Medicine, National Defense
   Medical Center; and Supervisor, Department of Nursing, Songshan Branch
   of Tri-Service General Hospital, Taipei, Taiwan, ROC. This study was
   funded by the Tri-Service General Hospital (TSGH-100-05-193 and
   MOST107-2314-B016-068), Taipei, Taiwan. The authors have no conflicts of
   interest to disclose.
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NR 50
TC 9
Z9 9
U1 1
U2 10
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0889-4655
EI 1550-5049
J9 J CARDIOVASC NURS
JI J. Cardiovasc. Nurs.
PD NOV-DEC
PY 2019
VL 34
IS 6
BP 491
EP 502
DI 10.1097/JCN.0000000000000602
PG 12
WC Cardiac & Cardiovascular Systems; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Cardiovascular System & Cardiology; Nursing
GA KG1HE
UT WOS:000509691800014
PM 31373956
DA 2025-06-11
ER

PT J
AU Volovelsky, O
   Weiss, R
AF Volovelsky, Oded
   Weiss, Ram
TI Fatty liver disease in obese children - relation to other metabolic risk
   factors
SO INTERNATIONAL JOURNAL OF PEDIATRIC OBESITY
LA English
DT Review
DE Fatty liver; metabolic syndrome; insulin resistance; lipid partitioning
ID INTIMA-MEDIA THICKNESS; INSULIN-RESISTANCE; NONALCOHOLIC
   STEATOHEPATITIS; CAROTID-ARTERY; ALANINE AMINOTRANSFERASE;
   CARDIOVASCULAR-DISEASE; PLASMA ADIPONECTIN; OXIDATIVE STRESS; VISCERAL
   FAT; ADOLESCENTS
AB Liver steatosis, known as non-alcoholic fatty liver disease (NAFLD) is common among obese children. Deposition of lipid within the liver represents part of an abnormal lipid partitioning pattern, most commonly associated with increased intra-abdominal fat. Lipid deposition in the liver can be a cause of peripheral insulin resistance via local acceleration of lipogenesis and a cause of hepatic insulin resistance leading to further compensatory hyperinsulinemia. The typical obese child with NAFLD will usually manifest other components of the insulin resistance syndrome such as dyslipidemia, hypertension and altered glucose metabolism. As liver steatosis itself is usually asymptomatic, a high index of suspicion for its presence should be present in obese insulin resistant youth who present with dyslipidemia or altered glucose metabolism or manifest anamnestic or physical signs that suggest the presence of insulin resistance.
C1 [Volovelsky, Oded; Weiss, Ram] Hebrew Univ Jerusalem, Dept Pediat, Hadassah Braun Sch Publ Hlth & Community Med, Fac Med, IL-91010 Jerusalem, Israel.
   [Weiss, Ram] Hebrew Univ Jerusalem, Dept Human Metab & Nutr, Hadassah Braun Sch Publ Hlth & Community Med, Fac Med, IL-91010 Jerusalem, Israel.
C3 Hebrew University of Jerusalem; Hebrew University of Jerusalem
RP Weiss, R (corresponding author), Hebrew Univ Jerusalem, Sch Med, Dept Human Metab & Nutr, Braun Sch Publ Hlth, IL-91010 Jerusalem, Israel.
EM ram.weiss@ekmd.huji.ac.il
RI Weiss, Ram/AAC-3964-2020
OI Volovelsky, Oded/0000-0002-5378-1045
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NR 47
TC 17
Z9 19
U1 0
U2 5
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 1747-7166
J9 INT J PEDIATR OBES
JI Int. J. Pediatr. Obes.
PD SEP
PY 2011
VL 6
SU 1
BP 59
EP 64
DI 10.3109/17477166.2011.583661
PG 6
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA 819XM
UT WOS:000294867700010
PM 21905818
DA 2025-06-11
ER

PT J
AU Corso, LML
   Wing, RR
   Tate, DF
   Espeland, MA
   Blanchard, BE
   McCaffery, JM
AF Corso, Lauren M. L.
   Wing, Rena R.
   Tate, Deborah F.
   Espeland, Mark A.
   Blanchard, Bruce E.
   McCaffery, Jeanne M.
TI Uric acid as a predictor of weight gain and cardiometabolic health in
   the Study of Novel Approaches to Weight Gain Prevention (SNAP)
   study
SO INTERNATIONAL JOURNAL OF OBESITY
LA English
DT Article
ID METABOLIC SYNDROME; YOUNG-ADULTS; OBESITY; RISK
AB Young adulthood is often a period of substantial weight gain increasing risk for obesity and cardiometabolic disease. Uric acid (UA), a clinical marker of oxidative stress, is associated with cardiometabolic dysfunction in established CVD, type 2 diabetes, and CKD. Yet, few trials have examined UA as a predictor of cardiometabolic risk in young, healthy populations, particularly in the context of weight gain prevention intervention. The purpose of this ancillary study was to examine UA in the Study of Novel Approaches to Weight Gain Prevention (SNAP), a randomized, controlled trial of weight gain prevention strategies in young healthy adults. UA was examined as a predictor of weight and cardiometabolic outcomes over 6 years; the impact of weight gain prevention interventions on UA was also examined. We found that higher baseline UA was a significant predictor of less favorable BMI, triglycerides, HDL, glucose, insulin, and HOMA, independent of age, sex, baseline weight, baseline level of the outcome variable, and weight gain prevention intervention. Additionally, >= 1% weight loss was associated with lower UA. UA is a promising biomarker for future weight gain and cardiometabolic risk in young adults that may respond to weight gain prevention.
C1 [Corso, Lauren M. L.; Blanchard, Bruce E.; McCaffery, Jeanne M.] Univ Connecticut, Dept Allied Hlth Sci, Storrs, CT 06269 USA.
   [Wing, Rena R.] Brown Univ, Miriam Hosp, Weight Control & Diabet Res Ctr, Providence, RI 02912 USA.
   [Wing, Rena R.] Brown Univ, Alpert Sch Med, Weight Control & Diabet Res Ctr, Providence, RI 02912 USA.
   [Tate, Deborah F.] Univ N Carolina, Gillings Sch Publ Hlth, Chapel Hill, NC 27515 USA.
   [Espeland, Mark A.] Wake Forest Sch Med, Winston Salem, NC 27101 USA.
C3 University of Connecticut; Lifespan Health Rhode Island; Miriam
   Hospital; Brown University; Brown University; University of North
   Carolina; University of North Carolina Chapel Hill; Wake Forest
   University
RP Corso, LML (corresponding author), Univ Connecticut, Dept Allied Hlth Sci, Storrs, CT 06269 USA.
EM lauren.lamberti@uconn.edu
OI Corso, Lauren/0000-0003-1758-7795; Tate, Deborah/0000-0002-4915-5308
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NR 20
TC 3
Z9 3
U1 1
U2 4
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0307-0565
EI 1476-5497
J9 INT J OBESITY
JI Int. J. Obes.
PD AUG
PY 2022
VL 46
IS 8
BP 1556
EP 1559
DI 10.1038/s41366-022-01131-1
EA MAY 2022
PG 4
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 3E5VQ
UT WOS:000789826700001
PM 35501471
DA 2025-06-11
ER

PT J
AU Mohebbi, I
   Shateri, K
   Seyedmohammadzad, M
AF Mohebbi, Iraj
   Shateri, Kamran
   Seyedmohammadzad, Mirhosein
TI The relationship between working schedule patterns and the markers of
   the metabolic syndrome: Comparison of shift workers with day workers
SO INTERNATIONAL JOURNAL OF OCCUPATIONAL MEDICINE AND ENVIRONMENTAL HEALTH
LA English
DT Article
DE Shift work; Insulin resistance; Metabolic syndrome; Abdominal obesity;
   Circadian clock
ID CORONARY-HEART-DISEASE; RISK-FACTORS; CARDIOVASCULAR-DISEASE;
   SOCIOECONOMIC-STATUS; CIRCADIAN CLOCK; UNITED-STATES; SYNDROME-X;
   OBESITY; STRESS; HEALTH
AB This study examined the effect of shift work on developing the metabolic syndrome by comparing groups of exposed and unexposed Iranian drivers.
   We considered as night-shift drivers those drivers whose shifts included at least 15 h per week between 9:00 p.m. and 7:00 a.m. Daytime drivers were defined as drivers working regularly without shift work. 3039 shift work drivers were selected. These were matched with non-shift workers. The differences in baseline characteristics and the prevalence of the components of the metabolic syndrome were assessed with Student's t test, and chi-square tests.
   We found central adiposity in 52.0% of the shift workers versus 42.6% of the day workers (p < 0.0001). The hypertension component was not significantly related to shift work (p > 0.05); but there were significant differences as regards other components of the metabolic syndrome (p < 0.0001). Among the shift workers, the odds ratios of the increased FBS, low HDL-C, higher TG levels, as well as higher waist circumference were 1.992 (95% CI: 1.697-2.337), 1.973 (95% CI: 1.759-2.213), 1.692 (95% CI: 1.527-1.874), and 1.460 (95% CI: 1.320-1.616), respectively. The metabolic syndrome was more common among the shift workers (OR = 1.495; 95% CI: 1.349-1.657).
   In evaluating such results, further consideration is needed to find pathophysiological clarification; in turn, stress linked to shift work must be considered to likely have had a relevant influence on the outcome. In our opinion, shift work acts as an occupational factor for the metabolic syndrome.
C1 [Mohebbi, Iraj] Urmia Univ Med Sci, Occupat Med Ctr, Dept Occupat Med, Orumiyeh, Iran.
   [Shateri, Kamran] Urmia Univ Med Sci, Dept Gastroenterol, Orumiyeh, Iran.
   [Seyedmohammadzad, Mirhosein] Urmia Univ Med Sci, Dept Cardiol, Orumiyeh, Iran.
C3 Urmia University of Medical Sciences; Urmia University of Medical
   Sciences; Urmia University of Medical Sciences
RP Mohebbi, I (corresponding author), Urmia Univ Med Sci, Occupat Med Ctr, Dept Occupat Med, Post Box 5756115111, Orumiyeh, Iran.
EM mohebbi_iraj@yahoo.co.uk
RI Mohebbi, Iraj/G-1494-2017; Shateri, Kamran/E-2048-2018
OI Shateri, Kamran/0000-0002-3855-3239; Mohebbi, Iraj/0000-0001-9158-5742;
   Shateri, Kamran/0009-0005-0614-9636
FU Urmia University of Medical Sciences, Urmia, Iran
FX This study entitled "Impact of shift work on metabolic syndrome" was
   supported by the Urmia University of Medical Sciences, Urmia, Iran.
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NR 42
TC 34
Z9 41
U1 0
U2 7
PU NOFER INST OCCUPATIONAL MEDICINE, POLAND
PI LODZ
PA SW TERESY 8, LODZ, 91-348, POLAND
SN 1232-1087
EI 1896-494X
J9 INT J OCCUP MED ENV
JI Int. J. Occup. Med. Environ. Health
PY 2012
VL 25
IS 4
BP 383
EP 391
DI 10.2478/S13382-012-0051-5
PG 9
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA 061XO
UT WOS:000312883700007
PM 23055229
OA gold
DA 2025-06-11
ER

PT J
AU Barton, BB
   Zagler, A
   Engl, K
   Rihs, L
   Musil, R
AF Barton, Barbara B.
   Zagler, Anja
   Engl, Katharina
   Rihs, Leonie
   Musil, Richard
TI Prevalence of obesity, metabolic syndrome, diabetes and risk of
   cardiovascular disease in a psychiatric inpatient sample: results of the
   Metabolism in Psychiatry (MiP) Study
SO EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
LA English
DT Article
DE Body mass index; Weight gain; Metabolic syndrome; Prevalence;
   Prospective study; Depression
ID GERMAN HEALTH INTERVIEW; WEIGHT-GAIN; CARDIOMETABOLIC RISK; WAIST
   CIRCUMFERENCE; PHYSICAL-ACTIVITY; MENTAL-DISORDERS; BODY-MASS;
   SCHIZOPHRENIA; POPULATION; PEOPLE
AB The information on prevalence of obesity, diabetes, metabolic syndrome (MetS) and cardiovascular risk (CVR) and on sociodemographic variables available in patients with psychiatric diseases about to be treated with weight gain-associated medication (e.g., clozapine, mirtazapine, quetiapine) is limited. In a naturalistic study, psychiatric inpatients (age: 18-75) of all F diagnoses according to ICD-10, who were about to be treated with weight gain-associated medication, were included. Demographic variables were assessed as well as biological parameters to calculate the Body Mass Index (BMI), MetS, diabetes and CVR. A total of 163 inpatients were included (60.1% male; mean age: 39.8 (+/- 15.1, 18-75 years). The three most common disorders were depression (46.0%), bipolar disorder (20.9%) and drug addiction (20.2%). The three most common pharmacotherapeutic agents prescribed were quetiapine (29.4%), mirtazapine (20.9%) and risperidone (12.9%). Of the included inpatients 30.1% were overweight, 17.2% obese, and 26.9% and 22.4% fulfilled the criteria for a MetS according to the International Diabetes Federation (IDF) and the National Expert Panel on Detection, Evaluation and Treatment of High Blood Cholesterol in Adults (NCEP ATP III), respectively, 3.8% had (pre)diabetes and 8.3% had a moderate and 1.9% a high CVR according to the Prospective Cardiovascular Munster (PROCAM) score. Detailed information is reported on all assessed parameters as well as on subgroup analyses concerning sociodemographic variables. The results suggest that psychiatric patients suffer from multiple metabolic disturbances in comparison to the general population. Monitoring weight, waist circumference, blood pressure and cholesterol regularly is, therefore, highly relevant.
C1 [Barton, Barbara B.; Zagler, Anja; Engl, Katharina; Rihs, Leonie; Musil, Richard] Ludwig Maximilians Univ Munchen, Dept Psychiat & Psychotherapy, Univ Hosp, Nussbaumstr 7, D-80336 Munich, Germany.
C3 University of Munich
RP Barton, BB (corresponding author), Ludwig Maximilians Univ Munchen, Dept Psychiat & Psychotherapy, Univ Hosp, Nussbaumstr 7, D-80336 Munich, Germany.
EM Barbara.Barton@med.uni-muenchen.de
RI Musil, Richard/AAF-4331-2020
OI Barton, Barbara Bianca/0000-0003-3614-9918
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NR 65
TC 18
Z9 19
U1 1
U2 18
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0940-1334
EI 1433-8491
J9 EUR ARCH PSY CLIN N
JI Eur. Arch. Psych. Clin. Neurosci.
PD AUG
PY 2020
VL 270
IS 5
BP 597
EP 609
DI 10.1007/s00406-019-01043-8
PG 13
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA ME9GM
UT WOS:000544962000011
PM 31302731
DA 2025-06-11
ER

PT J
AU Loucks, EB
   Magnusson, KT
   Cook, S
   Rehkopf, DH
   Ford, ES
   Berkman, LF
AF Loucks, Eric B.
   Magnusson, Kristjan T.
   Cook, Stephen
   Rehkopf, David H.
   Ford, Earl S.
   Berkman, Lisa F.
TI Socioeconomic position and the metabolic syndrome in early, middle, and
   late life: Evidence from NHANES 1999-2002
SO ANNALS OF EPIDEMIOLOGY
LA English
DT Article
DE socioeconomic factors; education; income; metabolic syndrome X
ID CORONARY-HEART-DISEASE; ARTERY RISK DEVELOPMENT; 3RD NATIONAL-HEALTH;
   NUTRITION EXAMINATION SURVEY; CARDIOVASCULAR-DISEASE; BLOOD-PRESSURE;
   YOUNG-ADULTS; HYPERTENSION; INEQUALITIES; STRESS
AB PURPOSE: To evaluate whether there is an association between socioeconomic position (SEP) and the metabolic syndrome at various ages, including adolescent, middle-aged and older participants in gender-specific analyses.
   METHODS: Participants were from the 1999-2002 National Health and Nutrition Examination Survey. SEP was measured by income and years of education. Metabolic syndrome was measured in adults using the American Heart Association guidelines and in adolescents using methods based on national reference data. Cross-sectional multivariable-adjusted logistic regression analyses were performed.
   RESULTS: In women aged 25 to 45 and 46 to 65 years, income below the poverty line (poverty income ratio [PIR] less than one) was associated with higher odds of metabolic syndrome compared with FIR greater than 3 (odds ratio [OR] = 4.90; 95% confidence interval (CI) = 2.24, 10.71, and OR = 2.54; CI= 1.38, 4.67, for the respective age groups) after adjustment for age, race/ethnicity, and menopause. Similar findings were observed for educational attainment. In adolescents, older adults (aged > 65 years), and males, income and education were not related to the metabolic syndrome.
   CONCLUSIONS: This report demonstrates that SEP is associated with the metabolic syndrome in females aged 25 to 65 years and is less strongly associated in males, adolescents, or older participants. These findings provide physiologic mechanistic evidence linking SEP to risk for coronary heart disease. (C) 2007 Elsevier Inc. All rights reserved.
C1 McGill Univ, Douglas Hosp, Dept Psychiat, Dept Epidemiol Biostat & Occupat Hlth,Res Ctr, Montreal, PQ H4H 1R3, Canada.
   Univ Iceland, Reykjavik, Iceland.
   Univ Rochester, Sch Med & Dent, Dept Pediat, Rochester, MN USA.
   Univ Calif San Francisco Berkeley Robert Wood Joh, San Francisco, CA 94143 USA.
   Ctr Dis Control & Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA USA.
   Harvard Univ, Sch Publ Hlth, Dept Soc Human Dev & Hlth, Boston, MA 02115 USA.
C3 McGill University; University of Iceland; University of Rochester;
   University of California System; University of California San Francisco;
   Centers for Disease Control & Prevention - USA; Harvard University;
   Harvard T.H. Chan School of Public Health
RP Loucks, EB (corresponding author), McGill Univ, Douglas Hosp, Dept Psychiat, Dept Epidemiol Biostat & Occupat Hlth,Res Ctr, 6875 LaSalle Blvd, Montreal, PQ H4H 1R3, Canada.
EM eric.loucks@mcgill.ca
RI Loucks, Eric/I-1272-2014
OI Rehkopf, David/0000-0002-7597-6513
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NR 48
TC 101
Z9 104
U1 0
U2 5
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1047-2797
EI 1873-2585
J9 ANN EPIDEMIOL
JI Ann. Epidemiol.
PD OCT
PY 2007
VL 17
IS 10
BP 782
EP 790
DI 10.1016/j.annepidem.2007.05.003
PG 9
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA 219EJ
UT WOS:000250067200005
PM 17697786
DA 2025-06-11
ER

PT J
AU Wang, JB
   Wang, YF
   Chen, F
   Ma, GJ
   Wang, DF
AF Wang, Jiabei
   Wang, Yingfang
   Chen, Feng
   Ma, Guojing
   Wang, Difei
TI Measurement of the Combined Levels of Serum Uric Acid and Alanine
   Aminotransferase and the Risk of Metabolic Syndrome in a Population Aged
   60 Years or More in Northeastern China
SO MEDICAL SCIENCE MONITOR
LA English
DT Article
DE Alanine Transaminase; Metabolic Syndrome X; Uric Acid
ID FATTY LIVER-DISEASE; INSULIN-RESISTANCE; ASSOCIATION; COMPONENTS; STRESS
AB Background: Serum uric acid (SUA) and alanine aminotransferase (ALT) levels are increased in patients with metabolic syndrome. This study aimed to investigate the association between the combined levels of SUA and ALT and the risk of metabolic syndrome in residents >= 60 years of age in Northeastern China.
   Material/Methods: A population study included nine communities in Shenyang, Northeast China, and 3,998 participants (1,434 men and 2,564 women) who were (3)60 years old. SUA and ALT measurements (levels 1-3) and clinical parameters were recorded. Metabolic syndrome was diagnosed according to the criteria of the National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III). The association between the combined SUA and ALT levels and metabolic syndrome was determined by multivariate logistic regression analysis in tertiles that included Groups 1-9.
   Results: The prevalence of metabolic syndrome was 43.2% (men), and 61.9% (women), and the prevalence and odds ratio (OR) values increased with increasing SUA and ALT levels. The OR values of metabolic syndrome in the ALT Groups 2-3 were 1.329 (95% CI, 1.137-1.554) and 2.362 (95% CI, 2.006-2.781), and in the SUA Groups 2-3 the OR values were 1.718 (95% CI, 1.466-2.015) and 2.743 (95% CI, 2.310-3.256). The OR of the combined increase in SUA and ALT and metabolic syndrome in Groups 1-9 ranged from 1.494-5.889 (all, p<0.05).
   Conclusions: Increased combined SUA and ALT was more significantly associated with metabolic syndrome than an increase in SUA or ALT alone.
C1 [Wang, Jiabei; Wang, Difei] Hubei Polytech Univ, Huangshi Cent Hosp, Dept Geriatr, Edong Healthcare Grp,Affiliated Hosp, Huangshi, Hubei, Peoples R China.
   [Wang, Yingfang; Chen, Feng; Ma, Guojing] China Med Univ, Affiliated Hosp 1, Dept Geriatr, Shenyang, Liaoning, Peoples R China.
C3 Hubei Polytechnic University; China Medical University
RP Wang, DF (corresponding author), Hubei Polytech Univ, Huangshi Cent Hosp, Dept Geriatr, Edong Healthcare Grp,Affiliated Hosp, Huangshi, Hubei, Peoples R China.
EM 16642407618@163.com
FU Science and Technology Projects of Shenyang [Z18-5-104]; Local
   Development Foundation of Science and Technology guided by the Central
   Commission [2016007024]; National Key Research and Development Program
   of China [2018YFC1311602]
FX This study was funded by the Science and Technology Projects of Shenyang
   (No. Z18-5-104), the Local Development Foundation of Science and
   Technology guided by the Central Commission (No. 2016007024), and The
   National Key Research and Development Program of China (No.
   2018YFC1311602)
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NR 40
TC 6
Z9 7
U1 0
U2 18
PU INT SCIENTIFIC INFORMATION, INC
PI MELVILLE
PA 150 BROADHOLLOW RD, STE 114, MELVILLE, NY 11747 USA
SN 1643-3750
J9 MED SCI MONITOR
JI Med. Sci. Monitor
PD JAN 20
PY 2020
VL 26
AR e916459
DI 10.12659/MSM.916459
PG 10
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA KE4UQ
UT WOS:000508552600001
PM 31958336
OA Green Published
DA 2025-06-11
ER

PT J
AU Richter, A
   Stapel, B
   Heitland, I
   Westhoff-Bleck, M
   Ponimaskin, E
   Stubbs, B
   Lichtinghagen, R
   Hartung, D
   Kahl, KG
AF Richter, A.
   Stapel, B.
   Heitland, I
   Westhoff-Bleck, M.
   Ponimaskin, E.
   Stubbs, B.
   Lichtinghagen, R.
   Hartung, D.
   Kahl, K. G.
TI Epicardial adipose tissue and adrenal gland volume in patients with
   borderline personality disorder
SO JOURNAL OF PSYCHIATRIC RESEARCH
LA English
DT Article
DE Epicardial adipose tissue; Adrenal gland volume; Borderline personality
   disorder; Major depressive disorder; Magnetic resonance imaging;
   Cardiometabolic risk
ID CARDIOVASCULAR RISK-FACTORS; CORONARY-ARTERY-DISEASE; FOLLOW-UP; MAJOR
   DEPRESSION; MYOCARDIAL-INFARCTION; PHYSICAL-ACTIVITY; FAT THICKNESS;
   WEIGHT-LOSS; MORTALITY; PATHOPHYSIOLOGY
AB Borderline personality disorder (BPD) is associated with an elevated mortality risk that is partially attributed to suicide, but few studies examined other possible causes of premature death. The present study compared epicardial adipose tissue (EAT) volume as a known early predictor of premature cardiovascular morbidity, cardiovascular risk indices, and adrenal gland volume (AGV) as an indicator for chronic hypothalamus-pituitaryadrenal (HPA) axis activation in females with borderline personality disorder (BPD), major depressive disorder (MDD) and in healthy individuals. Twenty-eight patients with BPD comorbid with MDD (BPD/MDD), 22 MDD patients and 26 healthy females (CTRL) of comparable age were included. EAT and AGV were assessed by magnetic resonance tomography; 10-year cardiovascular risk and diabetes risk were determined by PROCAM and FINDRISK score; metabolic syndrome was defined following National Cholesterol Education Adult Treatment Panel III R (NCEP/ATP III) criteria. MADRS was used to assess depression severity. After adjustment for age, body mass index (BMI), and physical activity, EAT and AGV were significantly increased in BPD/MDD compared to MDD and CTRL. EAT and AGV displayed a positive correlation. Finally, diabetes risk in BPD/MDD was elevated compared to CTRL and MDD. The present study highlights the increased cardiometabolic risk of BPD patients. We identify EAT accumulation as an early predictor and potential mediator of cardiovascular disease in BPD that appears to be driven at least in part by HPA axis dysregulation. Therefore, interventions that reduce EAT volume (i.e. exercise and diet) should be considered in the clinical management of BPD.
C1 [Richter, A.; Stapel, B.; Heitland, I; Kahl, K. G.] Hannover Med Sch, Dept Psychiat Social Psychiat & Psychotherapy, Carl Neuberg Str 1, D-30625 Hannover, Germany.
   [Westhoff-Bleck, M.] Hannover Med Sch, Dept Cardiol & Angiol, Hannover, Germany.
   [Ponimaskin, E.] Hannover Med Sch, Inst Cellular Neurophysiol, Hannover, Germany.
   [Stubbs, B.] Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Psychol Med, London, England.
   [Stubbs, B.] Maudsley NHS Fdn Trust, London, England.
   [Lichtinghagen, R.] Hannover Med Sch, Inst Clin Chem, Hannover, Germany.
   [Hartung, D.] Hannover Med Sch, Inst Diagnost & Intervent Radiol, Hannover, Germany.
C3 Hannover Medical School; Hannover Medical School; Hannover Medical
   School; University of London; King's College London; South London &
   Maudsley NHS Trust; Hannover Medical School; Hannover Medical School
RP Stapel, B (corresponding author), Hannover Med Sch, Dept Psychiat Social Psychiat & Psychotherapy, Carl Neuberg Str 1, D-30625 Hannover, Germany.
EM staple.britta@mh-hannover.de
RI Stubbs, Brendon/X-1904-2018; Heitland, Ivo/AAU-5671-2020; Heitland,
   Ivo/E-6324-2013; Stubbs, Brendon/C-5696-2015
OI Heitland, Ivo/0000-0002-6672-7857; Riesmeier, Alena/0000-0003-1336-3663;
   Stubbs, Brendon/0000-0001-7387-3791
FU Deutsche Forschungsgemeinschaft (DFG) via DFG [PO732]; REBIRTH funding
FX Evgeni Ponimaskin was supported through the Deutsche
   Forschungsgemeinschaft (DFG) via DFG grant PO732 and through REBIRTH
   funding. The funding sources were not involved in study design; in the
   collection, analysis and interpretation of data; in the writing of the
   report; or in the decision to submit the article for publication.
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NR 81
TC 8
Z9 8
U1 0
U2 8
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-3956
EI 1879-1379
J9 J PSYCHIATR RES
JI J. Psychiatr. Res.
PD DEC
PY 2021
VL 144
BP 323
EP 330
DI 10.1016/j.jpsychires.2021.10.039
EA OCT 2021
PG 8
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA WZ4XY
UT WOS:000719973300007
PM 34715600
DA 2025-06-11
ER

PT J
AU Takahashi, A
   Ohira, T
   Okazaki, K
   Yasumura, S
   Sakai, A
   Maeda, M
   Yabe, H
   Hosoya, M
   Ohtsuru, A
   Kawasaki, Y
   Shimabukuro, M
   Kazama, J
   Hashimoto, S
   Watanabe, K
   Nakano, H
   Hayashi, F
   Ohto, H
   Kamiya, K
   Ohira, H
AF Takahashi, Atsushi
   Ohira, Tetsuya
   Okazaki, Kanako
   Yasumura, Seiji
   Sakai, Akira
   Maeda, Masaharu
   Yabe, Hirooki
   Hosoya, Mitsuaki
   Ohtsuru, Akira
   Kawasaki, Yukihiko
   Shimabukuro, Michio
   Kazama, Junichiro
   Hashimoto, Shigeatsu
   Watanabe, Kazuyuki
   Nakano, Hironori
   Hayashi, Fumikazu
   Ohto, Hitoshi
   Kamiya, Kenji
   Ohira, Hiromasa
TI Effects of Psychological and Lifestyle Factors on Metabolic Syndrome
   Following the Fukushima Daiichi Nuclear Power Plant Accident: The
   Fukushima Health Management Survey
SO JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
LA English
DT Article
DE Metabolic syndrome; Lifestyle; Post-traumatic stress disorder; Disaster
ID ALCOHOL-CONSUMPTION; SMOKING-CESSATION; EVACUATION; RISK; METAANALYSIS;
   HYPERTENSION; POPULATION; PREVALENCE; DISORDER; WEIGHT
AB Aim: The Fukushima Daiichi Nuclear Power Plant accident dramatically changed the lifestyle of residents who lived near the plant. We evaluated the association of metabolic syndrome (MetS) with specific lifestyle- and disaster-related factors in residents following the accident.
   Methods: This cross-sectional study included 20,920 residents who underwent both the Comprehensive Health Check and the Mental Health and Lifestyle Survey from June 2011 to March 2012. Associations between MetS and lifestyle- and disaster-related factors, including psychological distress (post-traumatic stress disorder [PTSD]), were estimated using logistic regression analysis, adjusted for demographic and lifestyle factors, in 2019.
   Results: MetS was present in 30.4% of men and 11.5% of women. There were significant differences in smoking, drinking status, and PTSD prevalence between subjects with and without MetS. Multivariable logistic regression analysis showed that age, quitting smoking, and low physical activity were significantly associated with MetS. Moreover, PTSD and light to moderate drinking were also significantly associated with MetS in women.
   Conclusions: Lifestyle- and disaster-related factors, including PTSD, were associated with MetS among subjects who lived near the Fukushima Daiichi Nuclear Power Plant accident.
C1 [Takahashi, Atsushi; Ohira, Hiromasa] Fukushima Med Univ, Dept Gastroenterol, Sch Med, Fukushima, Japan.
   [Takahashi, Atsushi; Ohira, Tetsuya; Okazaki, Kanako; Yasumura, Seiji; Sakai, Akira; Maeda, Masaharu; Yabe, Hirooki; Hosoya, Mitsuaki; Ohtsuru, Akira; Kawasaki, Yukihiko; Shimabukuro, Michio; Kazama, Junichiro; Hashimoto, Shigeatsu; Watanabe, Kazuyuki; Nakano, Hironori; Hayashi, Fumikazu; Ohto, Hitoshi; Kamiya, Kenji] Fukushima Hlth Management Surv, Radiat Med Sci Ctr, Fukushima, Japan.
   [Ohira, Tetsuya; Okazaki, Kanako; Nakano, Hironori; Hayashi, Fumikazu] Fukushima Med Univ, Dept Epidemiol, Sch Med, Fukushima, Japan.
   [Yasumura, Seiji] Fukushima Med Univ, Dept Publ Hlth, Sch Med, Fukushima, Japan.
   [Sakai, Akira] Fukushima Med Univ, Dept Radiat Life Sci, Sch Med, Fukushima, Japan.
   [Maeda, Masaharu] Fukushima Med Univ, Dept Disaster Psychiat, Sch Med, Fukushima, Japan.
   [Yabe, Hirooki] Fukushima Med Univ, Dept Neuropsychiat, Sch Med, Fukushima, Japan.
   [Hosoya, Mitsuaki] Fukushima Med Univ, Dept Pediat, Sch Med, Fukushima, Japan.
   [Ohtsuru, Akira] Fukushima Med Univ, Dept Radiat Hlth Management, Sch Med, Fukushima, Japan.
   [Shimabukuro, Michio] Fukushima Med Univ, Dept Diabetol & Endocrinol, Sch Med, Fukushima, Japan.
   [Kazama, Junichiro] Fukushima Med Univ, Dept Nephrol & Hypertens, Sch Med, Fukushima, Japan.
   [Watanabe, Kazuyuki] Fukushima Med Univ, Dept Orthopaed Surg, Sch Med, Fukushima, Japan.
C3 Fukushima Medical University; Fukushima Medical University; Fukushima
   Medical University; Fukushima Medical University; Fukushima Medical
   University; Fukushima Medical University; Fukushima Medical University;
   Fukushima Medical University; Fukushima Medical University; Fukushima
   Medical University; Fukushima Medical University
RP Takahashi, A (corresponding author), 1 Hikarigaoka, Fukushima, Fukushima 9601295, Japan.
EM junior@fmu.ac.jp
OI hayashi, fumikazu/0000-0002-6888-6640
FU National Health Fund for Children and Adults Affected by the Nuclear
   Incident
FX We thank the expert committee members, advisors, and staff of the
   Fukushima Health Survey Group for conducting this survey and for their
   support. This work was supported by the National Health Fund for
   Children and Adults Affected by the Nuclear Incident. The findings and
   conclusions of this article are solely the responsibility of the authors
   and do not represent the official views of the Fukushima Prefectural
   Government.
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NR 39
TC 14
Z9 14
U1 0
U2 1
PU JAPAN ATHEROSCLEROSIS SOC
PI TOKYO
PA NICHINAI-KAIKAN B1, 3-28-8 HONGO BUNKYO-KU, TOKYO, 113-0033, JAPAN
SN 1340-3478
EI 1880-3873
J9 J ATHEROSCLER THROMB
JI J. Atheroscler. Thromb.
PY 2020
VL 27
IS 9
BP 1010
EP 1018
DI 10.5551/jat.52225
PG 9
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Cardiovascular System & Cardiology
GA NM0AR
UT WOS:000567768600009
PM 32009075
OA Green Published, gold
DA 2025-06-11
ER

PT S
AU Chrousos, GP
   Kino, T
AF Chrousos, George P.
   Kino, Tomoshige
BE Judd, LL
   Sternberg, EM
TI Glucocorticoid Signaling in the Cell Expanding Clinical Implications to
   Complex Human Behavioral and Somatic Disorders
SO GLUCOCORTICOIDS AND MOOD CLINICAL MANIFESTATIONS, RISK FACTORS, AND
   MOLECULAR MECHANISMS
SE Annals of the New York Academy of Sciences
LA English
DT Article; Proceedings Paper
CT Conference on Glucocorticoids and Mood - Clinical Manifestations, Risk
   Factors and Molecular Mechanisms
CY JUN 20-21, 2008
CL San Diego, CA
DE metabolic syndrome; osteoporosis; CDK5; GR phosphorylation; stress
   system; glucocorticoid resistance; glucocorticoid hypersensitivity
ID CYCLIN-DEPENDENT KINASE-5; FRAGMENT-LENGTH-POLYMORPHISM;
   PITUITARY-ADRENAL AXIS; RECEPTOR GENE; TRANSCRIPTIONAL ACTIVITY; N363S
   POLYMORPHISM; METABOLIC SYNDROME; STRESS SYSTEM; PROTEIN VPR;
   SENSITIVITY
AB Glucocorticoids contribute to the maintenance of basal and stress-related homeostasis in all higher organisms, and influence a large proportion of the expressed human genome, and their effects spare almost no organs or tissues. Glucocorticoids regulate many functions of the central nervous system, such as arousal, cognition, mood, sleep, the activity and direction of intermediary metabolism, the maintenance of a proper cardiovascular tone, the activity and quality of the immune and inflammatory reaction, including the manifestations of the sickness syndrome, and growth and reproduction. The numerous actions of glucocorticoids are mediated by a set of at least 16 glucocorticoid receptor (GR) isoforms forming homo- or hetero-dimers. The GRs consist of multifunctional domain proteins operating as ligand-dependent transcription factors that interact with many other cell signaling systems, including large and small G proteins. The presence of multiple GR monomers and homo- or hetero-dimers expressed in a cell-specific fashion at different quantities with quantitatively and qualitatively different transcriptional activities suggest that the glucocorticoid signaling system is highly stochastic. Glucocorticoids are heavily involved in human pathophysiology and influence life expectancy. Common behavioral and/or somatic complex disorders, such as anxiety, depression, insomnia, chronic pain and fatigue syndromes, obesity, the metabolic syndrome, essential hypertension, diabetes type 2, atherosclerosis with its cardiovascular sequelae, and osteoporosis, as well as autoimmune inflammatory and allergic disorders, all appear to have a glucocorticoid-regulated component.
C1 [Chrousos, George P.] Univ Athens, Sch Med, Dept Pediat 1, GR-11527 Athens, Greece.
   [Chrousos, George P.; Kino, Tomoshige] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Pediat Endocrinol Sect, Program Reprod & Adult Endocrinol, NIH, Bethesda, MD USA.
C3 Athens Medical School; National & Kapodistrian University of Athens;
   National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver
   National Institute of Child Health & Human Development (NICHD)
RP Chrousos, GP (corresponding author), Univ Athens, Sch Med, Aghia Sophia Childrens Hosp, Dept Pediat 1, GR-11527 Athens, Greece.
EM chrousge@med.uoa.gr
RI Chrousos, George/G-8702-2011
FU University of Athens, Athens, Greece; Eunice Kennedy Shriver National
   Institute of Child Health and Human Development, National Institutes of
   Health, Bethesda, MD
FX This is a synoptic review of work supported by the University of Athens,
   Athens, Greece, and the Intramural Research Program of the Eunice
   Kennedy Shriver National Institute of Child Health and Human
   Development, National Institutes of Health, Bethesda, MD.
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   ANN N Y ACA IN PRESS
   ANN N Y ACA IN PRESS
NR 77
TC 154
Z9 176
U1 0
U2 12
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN STREET, MALDEN 02148, MA USA
SN 0077-8923
BN 978-1-57331-748-1
J9 ANN NY ACAD SCI
JI Ann.NY Acad.Sci.
PY 2009
VL 1179
BP 153
EP 166
DI 10.1111/j.1749-6632.2009.04988.x
PG 14
WC Biochemistry & Molecular Biology
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA BMJ24
UT WOS:000272551200010
PM 19906238
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Klabbers, G
   Bosma, H
   Van der Does, AJW
   Vogelzangs, N
   Kempen, GIJM
   Van Eijk, JTM
   Penninx, BWJH
AF Klabbers, G.
   Bosma, H.
   Van der Does, A. J. W.
   Vogelzangs, N.
   Kempen, G. I. J. M.
   Van Eijk, J. Th. M.
   Penninx, B. W. J. H.
TI The educational patterning of health-related adversities in individuals
   with major depression
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Major depressive disorder; Educational inequalities; Metabolic syndrome;
   Lifestyle, treatment inequalities; Psychological function
ID METABOLIC SYNDROME; SOCIOECONOMIC INEQUALITIES; CARDIOVASCULAR-DISEASE;
   COGNITIVE REACTIVITY; RISK; OLDER; SYMPTOMS; HOPELESSNESS; DISORDERS;
   MORTALITY
AB Background: Major depressive disorder and depression severity are socially patterned, disfavouring individuals from lower socioeconomic groups. Depressive disorders are associated with several adverse health-related outcomes. We examined the educational patterning of somatic health, lifestyles, psychological function and treatment modalities in individuals suffering from major depressive disorder.
   Methods: We used cross-sectional medical and psychiatric data from 992 participants of The Netherlands Study of Depression and Anxiety (NESDA) with a diagnosed current major depressive disorder. Associations of education with somatic, lifestyle-related, and psychological outcomes, and with treatment modalities, adjusted for depression severity, were examined by means of (multinomial and binary) logistic and linear regression analyses.
   Results: In addition to and independent of major depressions being more severe in the less educated patients, metabolic syndrome, current smoking, low alcohol consumption, hopelessness and low control were more prevalent in a group of less educated individuals suffering from major depression, compared with their more highly educated peers. The less educated persons were more likely to be treated with antidepressant medication and less likely to receive psychotherapy treatment. None of these observations were explained by a higher depression severity in the less educated group.
   Limitations: The cross-sectional design does not allow us to make direct causal inferences regarding the mutual influences of the different health-related outcomes.
   Conclusions: Further research should explore the necessity and feasibility of routine screening for additional health risk, particularly among less educated depressed individuals. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Klabbers, G.; Bosma, H.; Van Eijk, J. Th. M.] Maastricht Univ, Dept Social Med, Sch CAPHRI, NL-6200 MD Maastricht, Netherlands.
   [Kempen, G. I. J. M.] Maastricht Univ, Dept Hlth Care & Nursing Sci, Sch CAPHRI, NL-6200 MD Maastricht, Netherlands.
   [Vogelzangs, N.; Penninx, B. W. J. H.] Vrije Univ Amsterdam Med Ctr, EMGO Inst Hlth & Care Res, Amsterdam, Netherlands.
   [Vogelzangs, N.; Penninx, B. W. J. H.] Vrije Univ Amsterdam Med Ctr, Dept Psychiat, Amsterdam, Netherlands.
   [Penninx, B. W. J. H.] Univ Groningen, Univ Med Ctr Groningen, Dept Psychiat, NL-9713 AV Groningen, Netherlands.
   [Van der Does, A. J. W.; Penninx, B. W. J. H.] Leiden Univ, Med Ctr, Dept Psychiat, NL-2300 RA Leiden, Netherlands.
   [Van der Does, A. J. W.; Penninx, B. W. J. H.] Leiden Univ, Inst Psychol, NL-2300 RA Leiden, Netherlands.
C3 Maastricht University; Maastricht University Medical Centre (MUMC);
   Maastricht University; Maastricht University Medical Centre (MUMC);
   Vrije Universiteit Amsterdam; VU UNIVERSITY MEDICAL CENTER; Vrije
   Universiteit Amsterdam; VU UNIVERSITY MEDICAL CENTER; University of
   Groningen; Leiden University - Excl LUMC; Leiden University; Leiden
   University Medical Center (LUMC); Leiden University; Leiden University -
   Excl LUMC
RP Klabbers, G (corresponding author), Maastricht Univ, Dept Social Med, Sch CAPHRI, POB 616, NL-6200 MD Maastricht, Netherlands.
EM g.klabbers@socmed.unimaas.nl
RI Bosma, Hans/A-6184-2013; Penninx, Brenda/S-7627-2017; Kempen,
   Gertrudis/H-5978-2016; Van der Does, Willem/B-1465-2008
OI Kempen, Gertrudis/0000-0002-7053-2198; Van der Does,
   Willem/0000-0002-9753-2454
FU Netherlands Organisation for Health Research and Development (ZonMw)
   [10-000-1002]; VU University Medical Center; GGZ inGeest; Arkin; Leiden
   University Medical Center; GGZ Rivierduinen; University Medical Center
   Groningen; Lentis; GGZ Friesland; GGZ Drenthe; IQ Healthcare;
   Netherlands Institute for Health Services Research (NIVEL); Netherlands
   Institute of Mental Health and Addiction (Trimbos); N.W.O.-Vici
   [453-06-005]
FX Funding for this study was provided by the Geestkracht program of The
   Netherlands Organisation for Health Research and Development (ZonMw,
   grant number 10-000-1002); ZonMw had no further role in study design; in
   the collection, analysis and interpretation of data; in the writing of
   the report; and in the decision to submit the paper for publication.The
   infrastructure for the NESDA study (www.nesda.nl) is funded through the
   Geestkracht program of The Netherlands Organisation for Health Research
   and Development (ZonMw, grant number 10-000-1002) and is supported by
   participating universities and mental health care organisations (VU
   University Medical Center, GGZ inGeest, Arkin, Leiden University Medical
   Center, GGZ Rivierduinen, University Medical Center Groningen, Lentis,
   GGZ Friesland, GGZ Drenthe, IQ Healthcare, Netherlands Institute for
   Health Services Research (NIVEL) and Netherlands Institute of Mental
   Health and Addiction (Trimbos)). AJWVdD is supported by N.W.O.-Vici
   grant # 453-06-005.
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NR 47
TC 5
Z9 5
U1 0
U2 7
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD OCT
PY 2010
VL 126
IS 1-2
BP 96
EP 102
DI 10.1016/j.jad.2010.02.128
PG 7
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA 658KD
UT WOS:000282488000012
PM 20299107
DA 2025-06-11
ER

PT J
AU Koning, SM
   Aronoff, J
   Chen, ST
   Hargrove, T
   Polos, J
   McDade, TW
AF Koning, Stephanie M.
   Aronoff, Jacob
   Chen, Shanting
   Hargrove, Taylor
   Polos, Jessica
   McDade, Thomas W.
TI Violence victimisation and young adult cardiometabolic health: the role
   of timing and social identity
SO ANNALS OF HUMAN BIOLOGY
LA English
DT Article
DE Violence; cardiometabolic health; metabolic syndrome; life course;
   adolescence
ID SENSITIVE PERIOD; RACE DIFFERENCES; UNITED-STATES; STRESS; CHILDHOOD;
   ADOLESCENT; RISK; ADVERSITY; EXPOSURE; DETERMINANTS
AB Background: Adolescent violence victimisation is associated with a spectrum of adult social and behavioural health outcomes, including adverse mental health symptoms. However, underlying social stress mechanisms linking adolescent victimisation to adult cardiometabolic health remains poorly understood. Aim: The current study aims to reveal how adolescent and adult interpersonal violence exposures each get "under the skin" to affect adult metabolic syndrome, including direct victimisation and, additionally, witnessing violence. Subjects and methods: We use a nationally representative longitudinal cohort, the National Longitudinal Study of Adolescent to Adult Health, and leverage a quasi-experimental approach, propensity score matching regression analysis (n = 14,267). Results: We find that adolescent violence exposure carries an enduring effect on young adult metabolic syndrome risk factor incidence and high-risk status, which is independent of young adult violence. Violence effects do not vary by sex or racial identity. Conclusion: In sum, adolescent exposure to direct interpersonal violence significantly affects young adult cardiometabolic health in ways suggesting adolescence is a sensitive period for the onset of harmful cardiometabolic effects in early adulthood. Findings warrant future study of underlying pathways and how these effects shape social inequities in cardiometabolic health among U.S. adults broadly.
C1 [Koning, Stephanie M.] Univ NV, Sch Publ Hlth, Reno, NV USA.
   [Aronoff, Jacob] AZ State Univ, Ctr Evolut & Med, Sch Human Evolut & Social Change, Tempe, AZ USA.
   [Chen, Shanting] Univ FL, Dept Psychol, Gainesville, FL USA.
   [Hargrove, Taylor] Univ NC Chapel Hill, Dept Sociol, Chapel Hill, NC USA.
   [Polos, Jessica] DePaul Univ, Master Publ Hlth Program, Chicago, IL USA.
   [McDade, Thomas W.] Northwestern Univ, Dept Anthropol, Evanston, IL USA.
   [McDade, Thomas W.] Northwestern Univ, Inst Policy Res, Evanston, IL USA.
C3 Nevada System of Higher Education (NSHE); University of Nevada Reno;
   DePaul University; Northwestern University; Northwestern University
RP Koning, SM (corresponding author), Univ Nevada, Sch Publ Hlth, 1664 N Virginia St, Reno, NV 89557 USA.
RI Koning, Stephanie/LLM-4907-2024
OI McDade, Thomas/0000-0001-5829-648X; Aronoff, Jacob/0000-0002-1422-801X;
   Polos, Jessica/0000-0002-3710-3471; Hargrove,
   Taylor/0000-0002-8759-1944; Koning, Stephanie M./0000-0003-0673-2483;
   Chen, Shanting/0000-0003-3390-2513
FU Eunice Kennedy Shriver National Institute of Child Health and Human
   Development of the National Institutes of Health [R21HD101757,
   F32HD102152, P2C HD050924]; National Institute on Aging at the
   University of North Carolina at Chapel Hill [U01 AG071448, U01AG071450];
   Eunice Kennedy Shriver National Institute of Child Health and Human
   Development (NICHD) [P01 HD31921];  [P01-HD31921]
FX Research reported in this publication was supported by the Eunice
   Kennedy Shriver National Institute of Child Health and Human Development
   of the National Institutes of Health under Award Numbers R21HD101757,
   F32HD102152, and P2C HD050924. The content is solely the responsibility
   of the authors and does not necessarily represent the official views of
   the National Institutes of Health. This research uses data from Add
   Health, a program project directed by Robert A. Hummer and funded by the
   National Institute on Aging cooperative agreements U01 AG071448 (Hummer)
   and U01AG071450 (Aiello and Hummer) at the University of North Carolina
   at Chapel Hill. Waves I-V data are from the Add Health Program Project,
   grant P01 HD31921 (Harris) from Eunice Kennedy Shriver National
   Institute of Child Health and Human Development (NICHD), with
   cooperative funding from 23 other federal agencies and foundations. Add
   Health was designed by J. Richard Udry, Peter S. Bearman, and Kathleen
   Mullan Harris at the University of North Carolina at Chapel Hill.
   Information on how to obtain the Add Health data files is available on
   the Add Health website (https://dev-addhealth.cpc.unc.edu/). No direct
   support was received from grant P01-HD31921 for this analysis.
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NR 97
TC 0
Z9 0
U1 0
U2 2
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0301-4460
EI 1464-5033
J9 ANN HUM BIOL
JI Ann. Hum. Biol.
PD DEC 31
PY 2024
VL 51
IS 1
AR 2390834
DI 10.1080/03014460.2024.2390834
PG 12
WC Anthropology; Biology; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Anthropology; Life Sciences & Biomedicine - Other Topics; Public,
   Environmental & Occupational Health
GA G6I7B
UT WOS:001317656800001
PM 39301955
OA gold
DA 2025-06-11
ER

PT J
AU Takahashi, S
   Nakamura, M
   Yonekura, Y
   Tanno, K
   Sakata, K
   Ogawa, A
   Kobayashi, S
AF Takahashi, Shuko
   Nakamura, Motoyuki
   Yonekura, Yuki
   Tanno, Kozo
   Sakata, Kiyomi
   Ogawa, Akira
   Kobayashi, Seiichiro
TI Association between relocation and changes in cardiometabolic risk
   factors: a longitudinal study in tsunami survivors of the 2011 Great
   East Japan Earthquake
SO BMJ OPEN
LA English
DT Article
DE EPIDEMIOLOGY; PREVENTIVE MEDICINE; PUBLIC HEALTH
ID ACUTE MYOCARDIAL-INFARCTION; HOME BLOOD-PRESSURE; PSYCHOLOGICAL STRESS;
   CARDIAC DEATH; VALIDATION; SCALE
AB Objectives The aim of this study is to determine changes in atherosclerotic cardiovascular risk factors with and without serious disaster-related mental and socioeconomic problems represented by relocation (REL).
   Design A longitudinal survey.
   Setting Multiphasic health check-ups for the general population affected by the 2011 Great East Japan Earthquake and Tsunami.
   Participants A total 6528 disaster survivors in heavily tsunami-damaged municipalities were recruited. Two sequential surveys were conducted and the data were analysed.
   Main outcome measures Multiphasic health check-ups including investigation of lifestyle and psychological and socioeconomic measures were performed in two sequential phases (8 and 18months) after the disaster for tsunami survivors with REL (n=3160) and without REL (n=3368). Longitudinal changes in cardiometabolic risk factors between the two phases were compared in the REL and non-REL groups.
   Results In sex/age-adjusted analysis, we found increases in body weight and waist circumference between the two phases that were significantly greater in the REL group than in the non-REL group (body weight:+0.31 (0.23 approximate to 0.39) versus -0.24 (-0.32 approximate to-0.16) kg, p<0.001; waist circumference:+0.58 (0.48 approximate to 0.68) versus+0.05 (-0.05 approximate to 0.15) cm, p<0.001)). A decrease in serum HDLC levels was found and again was significantly greater in the REL group than in the non-REL group (-0.65 (-0.96 approximate to-0.34) versus -0.09 (-0.39 approximate to 0.21) mg/dL, p=0.009). In addition, deterioration in physical activity, mental health and socioeconomic status was more prevalent in the REL group than in the non-REL group (all p<0.001).
   Conclusions This study suggests that relocation after the devastating tsunami was related to weight gain and decreasing HDLC among survivors, and this change was associated with prolonged psychological distress and socioeconomic problems after the disaster.
C1 [Takahashi, Shuko] Nagasaki Univ, Grad Sch Biomed Sci, Dept Int Hlth, Sakamoto, Nagasaki, Japan.
   [Takahashi, Shuko; Yonekura, Yuki; Tanno, Kozo; Sakata, Kiyomi] Iwate Med Univ, Sch Med, Dept Hyg & Prevent Med, Morioka, Iwate, Japan.
   [Nakamura, Motoyuki] Iwate Med Univ, Sch Med, Dept Internal Med, Div Cardioangiol, Morioka, Iwate, Japan.
   [Ogawa, Akira] Iwate Med Univ, Morioka, Iwate, Japan.
   [Kobayashi, Seiichiro] Iwate Med Univ, Sch Med, Dept Plast & Reconstruct Surg, Morioka, Iwate, Japan.
C3 Nagasaki University; Iwate Medical University; Iwate Medical University;
   Iwate Medical University; Iwate Medical University
RP Takahashi, S (corresponding author), Nagasaki Univ, Grad Sch Biomed Sci, Dept Int Hlth, Sakamoto, Nagasaki, Japan.; Takahashi, S (corresponding author), Iwate Med Univ, Sch Med, Dept Hyg & Prevent Med, Morioka, Iwate, Japan.
EM shutakahashi-iwt@umin.ac.jp
RI Tanno, Kozo/ABE-5165-2020; Takahashi, Shuko/AAD-3461-2022; Yonekura,
   Yuki/C-5973-2013
OI Yonekura, Yuki/0000-0002-2590-2022
FU Ministry of Health, Labour, and Welfare of Japan
   [H23-Tokubetsu-Shitei-002, H24-kenki-sitei-001]; Grants-in-Aid for
   Scientific Research [26461082, 26460776] Funding Source: KAKEN
FX The study was supported by a Health Labour Sciences Research Grant from
   the Ministry of Health, Labour, and Welfare of Japan
   (H23-Tokubetsu-Shitei-002; H24-kenki-sitei-001).
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NR 33
TC 28
Z9 30
U1 1
U2 3
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2044-6055
J9 BMJ OPEN
JI BMJ Open
PY 2016
VL 6
IS 5
AR e011291
DI 10.1136/bmjopen-2016-011291
PG 10
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA DP3SF
UT WOS:000378414700129
PM 27173815
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Vehmeijer, FOL
   Silva, CCV
   Derks, IPM
   El Marroun, H
   Oei, EHG
   Felix, JF
   Jaddoe, VWV
   Santos, S
AF Vehmeijer, Florianne O. L.
   Silva, Carolina C., V
   Derks, Ivonne P. M.
   El Marroun, Hanan
   Oei, Edwin H. G.
   Felix, Janine F.
   Jaddoe, Vincent W. V.
   Santos, Susana
TI Associations of Maternal Psychological Distress during Pregnancy with
   Childhood General and Organ Fat Measures
SO CHILDHOOD OBESITY
LA English
DT Article
DE adiposity; child; organ fat; pregnancy; psychological distress
ID POSTPARTUM DEPRESSIVE SYMPTOMS; CARDIOMETABOLIC RISK-FACTORS;
   SUBCUTANEOUS ADIPOSE-TISSUE; ABDOMINAL FAT; FREE MASS; STRESS; OBESITY;
   GROWTH; FETAL; CHILDREN
AB Background: Psychological distress during pregnancy may influence offspring adiposity. No studies assessed the associations with organ fat measures. We examined the associations of maternal psychological distress, depression, and anxiety during pregnancy with child general and organ fat measures. Methods: In 4161 mother-offspring pairs, psychological distress was self-reported in pregnancy. We obtained general fat measures, including BMI and fat mass index by dual-energy X-ray absorptiometry, and organ fat measures (in a subsample of 2447 children), including subcutaneous, visceral, and pericardial fat indices and liver fat fraction by magnetic resonance imaging at 10 years. Linear and logistic regression models were used. Results: Children of mothers with psychological distress had higher fat mass index [difference 0.14 (95% confidence interval {CI} 0.04-0.24) standard deviation scores (SDS)] and higher risk of obesity [odds ratio (OR) 1.73 (95% CI 1.09-2.74)]. Maternal anxiety was associated with higher BMI [difference 0.16 (95% CI 0.05-0.26) SDS], fat mass index [difference 0.19 (95% CI 0.10-0.28) SDS], and higher risks of overweight and obesity [OR 1.36 (95% CI 1.03-1.81), 1.78 (95% CI 1.13-2.81)]. Maternal anxiety was associated with higher subcutaneous and visceral fat indices and liver fat fraction [differences 0.16 (95% CI 0.03-0.29), 0.15 (95% CI 0.01-0.29), and 0.16 (95% CI 0.02-0.29) SDS]. No associations were observed for maternal depression. Conclusions: Psychological distress and anxiety, but not depression, during pregnancy were associated with higher child general and organ fat measures. A healthy mental state during pregnancy may be important for preventing child adiposity.
C1 [Vehmeijer, Florianne O. L.; Silva, Carolina C., V; Derks, Ivonne P. M.; El Marroun, Hanan; Felix, Janine F.; Jaddoe, Vincent W. V.; Santos, Susana] Univ Med Ctr Rotterdam, Erasmus MC, Generat Study Grp R, POB 2040, NL-3000 CA Rotterdam, Netherlands.
   [Vehmeijer, Florianne O. L.; Silva, Carolina C., V; El Marroun, Hanan; Felix, Janine F.; Jaddoe, Vincent W. V.] Univ Med Ctr Rotterdam, Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands.
   [Vehmeijer, Florianne O. L.; Silva, Carolina C., V; El Marroun, Hanan; Jaddoe, Vincent W. V.; Santos, Susana] Univ Med Ctr Rotterdam, Erasmus MC, Dept Pediat, Rotterdam, Netherlands.
   [Derks, Ivonne P. M.; El Marroun, Hanan] Univ Med Ctr Rotterdam, Erasmus MC, Dept Child & Adolescent Psychiat Psychol, Rotterdam, Netherlands.
   [Oei, Edwin H. G.] Univ Med Ctr Rotterdam, Erasmus MC, Dept Radiol & Nucl Med, Rotterdam, Netherlands.
C3 Erasmus University Rotterdam; Erasmus MC; Erasmus University Rotterdam;
   Erasmus MC; Erasmus University Rotterdam; Erasmus MC; Erasmus University
   Rotterdam; Erasmus MC; Erasmus University Rotterdam; Erasmus MC
RP Santos, S (corresponding author), Univ Med Ctr Rotterdam, Erasmus MC, Generat Study Grp R, POB 2040, NL-3000 CA Rotterdam, Netherlands.
EM s.dasilvasantos@erasmusmc.nl
RI Santos, Ana/KHY-6833-2024; Oei, Edwin/E-8174-2013
OI Derks, Ivonne/0009-0009-0137-3697; El Marroun,
   Hanan/0000-0002-9763-5015; Oei, Edwin/0000-0003-3727-3427; Costa Vicente
   Silva, Carolina/0009-0000-0490-6326; Santos, Susana/0000-0003-0613-3181;
   Vehmeijer, Florianne/0000-0002-1858-3430
FU Erasmus University Rotterdam, The Netherlands; Organization for Health
   Research and Development (ZonMw); Ministry of Health, Welfare and Sport;
   Netherlands Organization for Health Research and Development [VIDI
   016.136.361]
FX We gratefully acknowledge the contribution of the participating
   children, their mothers, general practitioners, hospitals, midwives, and
   pharmacies in Rotterdam. This phase of the Generation R Study was
   supported by the Erasmus MC, Erasmus University Rotterdam, The
   Netherlands, Organization for Health Research and Development (ZonMw)
   and the Ministry of Health, Welfare and Sport. V.V.W.J. received a grant
   from the Netherlands Organization for Health Research and Development
   (VIDI 016.136.361). The funders had no role in the design of the study,
   the data collection and analyses, the interpretation of data, or writing
   this report.
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NR 56
TC 11
Z9 12
U1 0
U2 8
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 2153-2168
EI 2153-2176
J9 CHILD OBES
JI Child Obes.
PD JUL 1
PY 2019
VL 15
IS 5
BP 313
EP 322
DI 10.1089/chi.2018.0300
EA MAY 2019
PG 10
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Pediatrics
GA ID7WT
UT WOS:000468301000001
PM 31058541
DA 2025-06-11
ER

PT J
AU Kohrt, BA
   Carruth, L
AF Kohrt, Brandon A.
   Carruth, Lauren
TI Syndemic effects in complex humanitarian emergencies: A framework for
   understanding political violence and improving multi-morbidity health
   outcomes
SO SOCIAL SCIENCE & MEDICINE
LA English
DT Article
DE Humanitarian emergencies; Political violence; Syndemic; War; Conflict;
   Mental health; Non-communicable diseases (NCDs)
ID INTIMATE PARTNER VIOLENCE; COMBAT-RELATED PTSD; MENTAL-HEALTH;
   POSTTRAUMATIC-STRESS; METABOLIC SYNDROME; CHILD SOLDIERS; SOMALI REGION;
   DEPRESSION
AB A hallmark of complex humanitarian emergencies is the collective exposure, often over extended periods of time, to political violence in the forms of war, terrorism, political intimidation, repression, unlawful detention, and forced displacement. Populations in complex humanitarian emergencies have higher risks of multiple co morbidities: mental disorders, infectious diseases, malnutrition, and chronic non-communicable diseases. However, there is wide variation in the health impacts both across and within humanitarian emergencies. Syndemic theory is an approach to conceptualizing disease and social determinants to understand differential patterns of multi-morbidity, elucidate underlying mechanisms, and better design interventions. Syndemic theory, if applied to complex humanitarian emergencies, has the potential to uncover origins of localized patterns of multi-morbidity resulting from political violence and historical inequities. In this paper, we present two case studies based on mixed-methods research to illustrate how syndemic models can be applied in complex humanitarian emergencies. First, in a Nepal case study, we explore different patterns of posttraumatic stress disorder (PTSD) and depression co-morbidity among female former child soldiers returning home after war. Despite comparable exposure to war-related traumas, girl soldiers in high-caste Hindu communities had 63% co morbidity of PTSD and depression, whereas girl soldiers in communities with mixed castes and religions, had 8% PTSD prevalence, but no cases of PTSD and depression co-morbidity. In the second case study, we explore the high rates of type 2 diabetes during a spike in political violence and population displacement. Despite low rates of obesity and other common risk factors, Somalis in Ethiopia experienced rising cases of and poor outcomes from type-2 diabetes. Political violence shapes healthcare resources, diets, and potentially, this epidemiological anomaly. Based on these case studies we propose a humanitarian syndemic research agenda for observational and intervention studies, with the central focus being that public health efforts need to target violence prevention at family, community, national, and global levels.
C1 [Kohrt, Brandon A.] George Washington Univ, Sch Med & Hlth Sci, Milken Sch Publ Hlth, Dept Psychiat & Behav Sci, Washington, DC 20052 USA.
   [Carruth, Lauren] Amer Univ, Sch Int Serv, Washington, DC 20016 USA.
C3 George Washington University; American University
RP Kohrt, BA (corresponding author), George Washington Univ, Sch Med & Hlth Sci, Milken Sch Publ Hlth, Dept Psychiat & Behav Sci, Washington, DC 20052 USA.
EM bkohrt@gwu.edu; lcarruth@american.edu
RI Kohrt, Brandon/MSX-8041-2025; Carruth, Lauren/K-1934-2015
OI Carruth, Lauren/0000-0001-6403-9930
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Z9 22
U1 1
U2 18
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0277-9536
EI 1873-5347
J9 SOC SCI MED
JI Soc. Sci. Med.
PD FEB
PY 2022
VL 295
SI SI
AR 113378
DI 10.1016/j.socscimed.2020.113378
EA FEB 2022
PG 11
WC Public, Environmental & Occupational Health; Social Sciences, Biomedical
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; Biomedical Social Sciences
GA 1C5IG
UT WOS:000793152100016
PM 33051023
OA Green Published
DA 2025-06-11
ER

PT J
AU Henning, SW
   Jaishankar, D
   Barse, LW
   Dellacecca, ER
   Lancki, N
   Webb, K
   Janusek, L
   Mathews, HL
   Price, RN
   Le Poole, IC
AF Henning, Steven W.
   Jaishankar, Dinesh
   Barse, Levi W.
   Dellacecca, Emilia R.
   Lancki, Nicola
   Webb, Kirsten
   Janusek, Linda
   Mathews, Herbert L.
   Price, Ronald N., Jr.
   Le Poole, I. Caroline
TI The relationship between stress and vitiligo: Evaluating perceived
   stress and electronic medical record data
SO PLOS ONE
LA English
DT Article
ID PSYCHOLOGICAL STRESS; METABOLIC SYNDROME; OXIDATIVE STRESS;
   AUTOIMMUNE-DISEASES; IMMUNE FUNCTION; ASSOCIATION; DYSFUNCTION;
   PREVALENCE; DEPRESSION; ADULTS
AB Vitiligo is a T-cell mediated skin disorder characterized by progressive loss of skin color. In individuals genetically predisposed to the disease, various triggers contribute to the initiation of vitiligo. Precipitating factors can stress the skin, leading to T-cell activation and recruitment. Though hereditary factors are implicated in the pathogenesis of vitiligo, it is unknown whether precipitating, stressful events play a role in vitiligo. To understand this, we utilized a validated perceived stress scale (PSS) to measure this parameter in vitiligo patients compared to persons without vitiligo. Additionally, we probed a clinical database, using a knowledge linking software called ROCKET, to gauge stress-related conditions in the vitiligo patient population. From a pool of patients in an existing database, a hundred individuals with vitiligo and twenty-five age- and sex-matched comparison group of individuals without vitiligo completed an online survey to quantify their levels of perceived stress. In parallel, patients described specifics of their disease condition, including the affected body sites, the extent, duration and activity of their vitiligo. Perceived stress was significantly higher among vitiligo individuals compared to those without vitiligo. ROCKET analyses suggested signs of metabolic-related disease (i.e., 'stress') preceding vitiligo development. No correlation was found between perceived stress and the stage or the extent of disease, suggesting that elevated stress may not be a consequence of pigment loss alone. The data provide further support for stress as a precipitating factor in vitiligo development.
C1 [Henning, Steven W.; Barse, Levi W.] Loyola Univ Chicago, Oncol Res Inst, Maywood, IL USA.
   [Jaishankar, Dinesh; Dellacecca, Emilia R.] Northwestern Univ, Feinberg Sch Med, Dept Dermatol, Chicago, IL 60611 USA.
   [Lancki, Nicola; Le Poole, I. Caroline] Northwestern Univ, Dept Prevent Med, Chicago, IL 60611 USA.
   [Webb, Kirsten] Loyola Univ Chicago, Div Dermatol, Maywood, IL USA.
   [Janusek, Linda] Loyola Univ Chicago, Marcella Niehoff Sch Nursing, Maywood, IL USA.
   [Mathews, Herbert L.] Loyola Univ Chicago, Dept Microbiol & Immunol, Maywood, IL USA.
   [Price, Ronald N., Jr.] Loyola Univ Chicago, Off Informat & Syst Dev, Maywood, IL USA.
   [Le Poole, I. Caroline] Northwestern Univ, Feinberg Sch Med, Dept Microbiol & Immunol, Chicago, IL USA.
C3 Loyola University Chicago; Northwestern University; Feinberg School of
   Medicine; Northwestern University; Loyola University Chicago; Loyola
   University Chicago; Loyola University Chicago; Loyola University
   Chicago; Northwestern University; Feinberg School of Medicine
RP Jaishankar, D (corresponding author), Northwestern Univ, Feinberg Sch Med, Dept Dermatol, Chicago, IL 60611 USA.
EM dinesh.jaishankar@northwestern.edu
OI Dellacecca, Emilia/0000-0001-9031-2240; Le Poole, I.
   Caroline/0000-0001-6853-4007
FU National Cancer Institute [R01CA191317]
FX CLP, R01CA191317, National Cancer Institute; https://www.cancer.gov/The
   funders had no role in study design, data collection and analysis,
   decision to publish, or preparation of the manuscript.
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NR 75
TC 35
Z9 38
U1 0
U2 9
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JAN 27
PY 2020
VL 15
IS 1
AR e0227909
DI 10.1371/journal.pone.0227909
PG 14
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Science & Technology - Other Topics
GA LP8YP
UT WOS:000534603400032
PM 31986193
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Soares, ALG
   Gonçalves, H
   Matijasevich, A
   Sequeira, M
   Smith, GD
   Menezes, AMB
   Assunçao, MC
   Wehrmeister, FC
   Fraser, A
   Howe, LD
AF Goncalves Soares, Ana Luiza
   Goncalves, Helen
   Matijasevich, Alicia
   Sequeira, Maija
   Smith, George Davey
   Menezes, Ana M. B.
   Assuncao, Maria Cecilia
   Wehrmeister, Fernando C.
   Fraser, Abigail
   Howe, Laura D.
TI Parental Separation and Cardiometabolic Risk Factors in Late
   Adolescence: A Cross-Cohort Comparison
SO AMERICAN JOURNAL OF EPIDEMIOLOGY
LA English
DT Article
DE adolescents; ALSPAC; cardiometabolic risk factors; cohort studies;
   divorce; parental separation; Pelotas Birth Cohort
ID ADVERSE CHILDHOOD EXPERIENCES; MENTAL-HEALTH; PHYSICAL HEALTH; DIVORCE;
   CHILDREN; SMOKING; ASSOCIATION; PREVALENCE; ADULTS; ABUSE
AB The aim of this study was to explore the association between parental separation during childhood ( up to 18 years of age) and cardiometabolic risk factors (body mass index, fat mass index, blood pressure, physical activity, smoking, and alcohol consumption) in late adolescence using a cross-cohort comparison and to explore whether associations differ according to the age at which the parental separation occurred and the presence or absence of parental conflict prior to separation. Data from the Avon Longitudinal Study of Parents and Children (ALSPAC, United Kingdom) (1991-2011) and the 1993 Pelotas Birth Cohort (Brazil) (1993-2011) were used. The associations of parental separation with children's cardiometabolic risk factors were largely null. Higher odds of daily smoking were observed in both cohorts for those adolescents whose parents separated (for ALSPAC, odds ratio = 1.46; for Pelotas Birth Cohort, odds ratio = 1.98). Some additional associations were observed in the Pelotas Birth Cohort but were generally in the opposite direction to our a priori hypothesis: Parental separation was associated with lower blood pressure and fat mass index, and with more physical activity. No consistent differences were observed when analyses were stratified by child's age at parental separation or parental conflict.
C1 [Goncalves Soares, Ana Luiza; Goncalves, Helen; Menezes, Ana M. B.; Assuncao, Maria Cecilia; Wehrmeister, Fernando C.] Univ Fed Pelotas, Postgrad Program Epidemiol, Rua Marechal Deodoro 1160,3 Piso, BR-96020220 Pelotas, RS, Brazil.
   [Matijasevich, Alicia] Univ Sao Paulo, Dept Prevent Med, Sao Paulo, Brazil.
   [Goncalves Soares, Ana Luiza; Sequeira, Maija; Smith, George Davey; Fraser, Abigail; Howe, Laura D.] Univ Bristol, MRC Integrat Epidemiol Unit, Sch Social & Community Med, Bristol, Avon, England.
C3 Universidade Federal de Pelotas; Universidade de Sao Paulo; University
   of Bristol
RP Soares, ALG (corresponding author), Univ Fed Pelotas, Postgrad Program Epidemiol, Rua Marechal Deodoro 1160,3 Piso, BR-96020220 Pelotas, RS, Brazil.
EM analuiza.nutri@gmail.com
RI Soares, Ana/E-4393-2014; Menezes, Ana/G-7266-2012; Gonçalves,
   Helen/M-1603-2017; Matijasevich, Alicia/C-5576-2009; Wehrmeister,
   Fernando C/A-3006-2014; Davey Smith, George/A-7407-2013
OI Venkatasubramanian, Siddharth/0000-0002-5860-0768; Goncalves,
   Helen/0000-0001-6470-3352; Goncalves Soares, Ana
   Luiza/0000-0003-2763-4647; Matijasevich, Alicia/0000-0003-0060-1589;
   Wehrmeister, Fernando C/0000-0001-7137-1747; Davey Smith,
   George/0000-0002-1407-8314; Sequeira, Maija-Eliina/0000-0003-2882-5381;
   Reis, AlessanRSS/0000-0001-8486-7469; Howe, Laura/0000-0003-3357-2796;
   Fraser, Abigail/0000-0002-7741-9470
FU Wellcome Trust; European Union; National Support Program for Centers of
   Excellence (PRONEX); Brazilian National Research Council (CNPq);
   Brazilian Ministry of Health; United Kingdom Medical Research Council;
   University of Bristol; Career Development Awards from the United Kingdom
   Medical Research Council [MR/M020894/1, MR/M009351/1]; United Kingdom
   Medical Research Council [MC_UU_12013/5]; MRC [MR/M009351/1,
   MC_UU_12013/1, MR/M020894/1] Funding Source: UKRI
FX This article is based on data from the study Pelotas Birth Cohort, 1993,
   and the Avon Longitudinal Study of Parents and Children (ALSPAC). The
   1993 Pelotas Birth Cohort is conducted by the Postgraduate Program in
   Epidemiology at Federal University of Pelotas in collaboration with the
   Brazilian Public Health Association (ABRASCO). Funding for this study
   was provided by the Wellcome Trust, the European Union, National Support
   Program for Centers of Excellence (PRONEX), the Brazilian National
   Research Council (CNPq), and the Brazilian Ministry of Health. ALSPAC
   receives core funding from the United Kingdom Medical Research Council,
   the Wellcome Trust and the University of Bristol. A.L.G.S., H.G., A.M.,
   A.M.B.M., M.C.A., and F.C.W. are supported by the Brazilian National
   Research Council (CNPq). L.D.H. and A.F. are supported by Career
   Development Awards from the United Kingdom Medical Research Council
   (grants MR/M020894/1 and MR/M009351/1, respectively). A.L.G.S., G.D.S.,
   A.F. and L.D.H. work in a unit that receives funds from the United
   Kingdom Medical Research Council (grant MC_UU_12013/5).
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NR 44
TC 11
Z9 11
U1 0
U2 15
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0002-9262
EI 1476-6256
J9 AM J EPIDEMIOL
JI Am. J. Epidemiol.
PD MAY 15
PY 2017
VL 185
IS 10
BP 898
EP 906
DI 10.1093/aje/kwx007
PG 9
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA EV7ES
UT WOS:000401938300006
PM 28444145
OA Green Published, Green Submitted, hybrid
DA 2025-06-11
ER

PT J
AU Gill, H
   Kang, S
   Lee, Y
   Rosenblat, JD
   Brietzke, E
   Zuckerman, H
   McIntyre, RS
AF Gill, Hartej
   Kang, Simratdeep
   Lee, Yena
   Rosenblat, Joshua D.
   Brietzke, Elisa
   Zuckerman, Hannah
   McIntyre, Roger S.
TI The long-term effect of bariatric surgery on depression and anxiety
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Review
DE Bariatric surgery; Metabolic syndrome; Obesity; Bipolar disorder; Major
   depressive disorder; Generalized Anxiety Disorder
ID GASTRIC BYPASS-SURGERY; QUALITY-OF-LIFE; WEIGHT-LOSS; FOLLOW-UP;
   PATIENTS SEEKING; SEVERE OBESITY; SYMPTOMS; OUTCOMES; ADOLESCENTS;
   TRENDS
AB Background: No previous review has comprehensively assessed long-term changes in anxiety and depressive symptoms in bariatric surgery patients. This systematic review assessed the effects of bariatric surgery on long-term reductions (>= 24 months) in anxiety and depressive symptom severity in morbidly obese (>= 35 BMI kg/m(2)) participants. Short term effects (< 24 months) are briefly reviewed for context.
   Methods: PsychINFO, Google Scholar and PubMed databases were systematically searched for prospective cohort studies published from inception to 14 June 2018 that evaluated long-term (>= 24 months) changes in anxiety and depressive symptom severity in bariatric surgery patients with a BMI >= 35 kg/m(2) using a combination of the following search terms: bariatric surgery (and surgical approaches included under this term), obesity, depression, depressive disorder, anxiety, anxious, psychiatric disorders, mood disorders.
   Results: We reviewed 2058 articles for eligibility; 14 prospective studies were included in the systematic review. 13 studies (93%) reported significant reductions in depressive symptom severity 2-3 years after bariatric surgery. However, all studies recorded statistically significant reductions in depressive symptoms at the conclusion of the study. Similarly, there were reductions in overall anxiety symptom severity at >= 24 months follow-up (k = 8 studies, n = 1590 pooled). Pre-operative anxiety or depression scores did not predict outcomes of postoperative BMI. Similarly, post-surgery weight loss did not predict changes in anxiety symptoms.
   Limitations: Very few studies assessed anxiety or depression as a primary outcome. Therefore, we cannot suggest bariatric surgery as a stand-alone therapeutic tool for anxiety and depression based on our findings.
   Conclusion: Currently available evidence suggests that bariatric surgery is associated with long-term reductions in anxiety and depressive symptoms. This supports existing literature showing that metabolic treatments may be a viable therapeutic intervention for mood disorders.
C1 [Gill, Hartej; Kang, Simratdeep; Lee, Yena; Rosenblat, Joshua D.; Brietzke, Elisa; Zuckerman, Hannah; McIntyre, Roger S.] Univ Hlth Network, Mood Disorders Psychopharmacol Unit, Toronto, ON, Canada.
   [Lee, Yena; McIntyre, Roger S.] Univ Toronto, Inst Med Sci, Toronto, ON, Canada.
   [Lee, Yena; McIntyre, Roger S.] Brain & Cognit Discovery Fdn, Toronto, ON, Canada.
   [Rosenblat, Joshua D.; McIntyre, Roger S.] Univ Toronto, Dept Psychiat, Toronto, ON, Canada.
   [Brietzke, Elisa] Univ Fed Sao Paulo, Dept Psychiat, Sao Paulo, Brazil.
   [McIntyre, Roger S.] Univ Toronto, Dept Pharmacol, Toronto, ON, Canada.
   [McIntyre, Roger S.] Univ Hlth Network, 399 Bathurst St,MP 9-325, Toronto, ON M5T 2S8, Canada.
C3 University of Toronto; University Health Network Toronto; University of
   Toronto; University of Toronto; Universidade Federal de Sao Paulo
   (UNIFESP); University of Toronto; University of Toronto; University
   Health Network Toronto
RP McIntyre, RS (corresponding author), Univ Hlth Network, Mood Disorders Psychopharmacol Unit, Toronto, ON, Canada.; McIntyre, RS (corresponding author), Univ Toronto, Inst Med Sci, Toronto, ON, Canada.; McIntyre, RS (corresponding author), Brain & Cognit Discovery Fdn, Toronto, ON, Canada.; McIntyre, RS (corresponding author), Univ Toronto, Dept Psychiat, Toronto, ON, Canada.; McIntyre, RS (corresponding author), Univ Toronto, Dept Pharmacol, Toronto, ON, Canada.; McIntyre, RS (corresponding author), Univ Hlth Network, 399 Bathurst St,MP 9-325, Toronto, ON M5T 2S8, Canada.
EM Roger.McIntyre@uhn.ca
RI Gill, Hartej/AAA-3576-2022; McIntyre, Roger/AAU-1000-2020; Lee,
   Yena/L-5505-2019; Brietzke, Elisa/G-9559-2012
OI Lee, Yena/0000-0003-0629-9456; Rosenblat, Joshua/0000-0002-4773-2191
FU Mood Disorders and Pharmacology Unit
FX We want to extend our appreciation to the team at the Mood Disorders and
   Pharmacology Unit for providing their support and expertise in the
   writing of this manuscript.
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NR 38
TC 130
Z9 137
U1 0
U2 21
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD MAR 1
PY 2019
VL 246
BP 886
EP 894
DI 10.1016/j.jad.2018.12.113
PG 9
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA HJ6EE
UT WOS:000457276200109
PM 30795495
DA 2025-06-11
ER

PT J
AU Pervanidou, P
   Bastaki, D
   Chouliaras, G
   Papanikolaou, K
   Kanaka-Gantenbein, C
   Chrousos, G
AF Pervanidou, Panagiota
   Bastaki, Despoina
   Chouliaras, Giorgos
   Papanikolaou, Katerina
   Kanaka-Gantenbein, Christina
   Chrousos, George
TI Internalizing and externalizing problems in obese children and
   adolescents: associations with daily salivary cortisol concentrations
SO HORMONES-INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM
LA English
DT Article
DE Anxiety; Behavior; Children; Cortisol; Obesity; Stress
ID ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; BODY-MASS INDEX;
   POSTTRAUMATIC-STRESS-DISORDER; PRESCHOOL-AGED CHILDREN;
   OF-THE-LITERATURE; METABOLIC SYNDROME; LONGITUDINAL ASSOCIATIONS;
   AWAKENING RESPONSE; MAJOR DEPRESSION; CONDUCT DISORDER
AB OBJECTIVE: Pediatric obesity commonly co-exists with emotional and behavioral disorders, while disturbed cortisol concentrations have been reported in both obese and chronically stressed individuals with anxiety and/or depression. We investigated the prevalence of internalizing and externalizing problems, reported by both parents and children, in a clinical population of obese children (OC) compared to normal-weight children. We examined the role of cortisol as a potential mediator between obesity and such problems. DESIGN: We compared 110 obese with 31 normal-weight children. The Greek version of the child behavior checklist (CBCL) and the youth self-report (YSR) were used and salivary cortisol was determined serially five times a day. RESULTS: T-scores of internalizing problems (anxiety/depression, social withdrawal, somatic complains) reported by both children (49.3 +/- 12.3 vs. 43.2 +/- 9.1) and mothers (60.6 +/- 11.3 vs. 50.6 +/- 10.4) were significantly higher (p=0.03 and p<0.001, respectively) in the obese than in the lean children. Externalizing problems (delinquency, rule-breaking behaviors) reported only by mothers were significantly higher in the OC (57.2 +/- 10.5 vs. 48.2 +/- 13.3, p=0.003). The cortisol area under the curve (AUC) was significantly smaller (p=0.03) in the OC than in the controls; however, a cortisol correlation with internalizing/externalizing symptoms was not observed. CONCLUSIONS: There is a high prevalence of internalizing and externalizing problems in a clinical population of OC. A mediation effect of cortisol in the relation between internalizing/externalizing problems and obesity could not be supported.
C1 [Pervanidou, Panagiota; Bastaki, Despoina; Chouliaras, Giorgos; Kanaka-Gantenbein, Christina; Chrousos, George] Univ Athens, Sch Med, Aghia Sophia Childrens Hosp, Dept Pediat 1, GR-11527 Athens, Greece.
   [Papanikolaou, Katerina] Univ Athens, Sch Med, Aghia Sophia Childrens Hosp, Dept Child Psychiat, GR-11527 Athens, Greece.
C3 The Aghia Sophia Children's Hospital; Athens Medical School; National &
   Kapodistrian University of Athens; National & Kapodistrian University of
   Athens; Athens Medical School; The Aghia Sophia Children's Hospital
RP Pervanidou, P (corresponding author), Univ Athens, Sch Med, Dept Pediat 1, Dev & Behav Pediat, Thivon & Levadias Str, GR-11527 Athens, Greece.
EM ppervanid@med.uoa.gr
RI Pervanidou, Panagiota/ABI-6356-2020; Kanaka-Gantenbein,
   Christina/AAP-3697-2020; Papanikolaou, Katerina/AAB-4771-2020; Chrousos,
   George/G-8702-2011
OI Pervanidou, Panagiota/0000-0002-6593-6489
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NR 66
TC 21
Z9 22
U1 1
U2 14
PU HELLENIC ENDOCRINE SOC
PI ATHENS
PA 14 ALEXANDRAS AVE, ATHENS, 106 82, GREECE
SN 1109-3099
J9 HORM-INT J ENDOCRINO
JI Horm.-Int. J. Endocrinol. Metab.
PD OCT-DEC
PY 2015
VL 14
IS 4
BP 623
EP 631
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA DD9KG
UT WOS:000370243500014
PM 26188233
DA 2025-06-11
ER

PT J
AU Vanhala, M
   Jokelainen, J
   Keinänen-Kiukaanniemi, S
   Kumpusalo, E
   Koponen, H
AF Vanhala, M.
   Jokelainen, J.
   Keinanen-Kiukaanniemi, S.
   Kumpusalo, E.
   Koponen, H.
TI Depressive symptoms predispose females to metabolic syndrome: a 7-year
   follow-up study
SO ACTA PSYCHIATRICA SCANDINAVICA
LA English
DT Article
DE Beck depression inventory; cholesterol; depression; metabolic syndrome;
   triglycerides
ID 3RD NATIONAL-HEALTH; INSULIN-RESISTANCE; MAJOR DEPRESSION; RISK-FACTOR;
   OBESITY; ASSOCIATION; INVENTORY; STATEMENT; DISORDER; WOMEN
AB To evaluate the risk for developing metabolic syndrome when having depressive symptoms.
   The prevalence of depressive symptoms and metabolic syndrome at baseline, and after a 7-year follow-up as measured with Beck depression inventory (BDI), and using the modified National Cholesterol Education Program - Adult Treatment Panel III criteria for metabolic syndrome (MetS) were studied in a middle-aged population-based sample (n = 1294).
   The logistic regression analysis showed a 2.5-fold risk (95% CI: 1.2-5.2) for the females with depressive symptoms (BDI >= 10) at baseline to have MetS at the end of the follow-up. The risk was highest in the subgroup with more melancholic symptoms evaluated with a summary score of the melancholic items in BDI (OR 6.81, 95% CI: 2.09-22.20). In men, there was no risk difference.
   The higher risks for MetS in females with depressive symptoms at baseline suggest that depression may be an important predisposing factor for the development of MetS.
C1 [Koponen, H.] Kuopio Univ Hosp, Dept Psychiat, FIN-70211 Kuopio, Finland.
   [Vanhala, M.] Cent Hosp Middle Finland, Unit Family Practice, Jyvaskyla, Finland.
   [Jokelainen, J.; Keinanen-Kiukaanniemi, S.] Univ Oulu, Inst Hlth Sci, Oulu, Finland.
   [Jokelainen, J.; Keinanen-Kiukaanniemi, S.] Oulu Univ Hosp, Unit Gen Practice, Oulu, Finland.
   [Kumpusalo, E.] Oulu Hlth Ctr, Oulu, Finland.
   [Kumpusalo, E.] Univ Kuopio, Dept Family Med, Sch Publ Hlth & Clin Nutr, FIN-70211 Kuopio, Finland.
   [Kumpusalo, E.] Kuopio Univ Hosp, Unit Family Practice, FIN-70211 Kuopio, Finland.
   [Koponen, H.] Univ Kuopio, Dept Psychiat, Acad Finland, FIN-70211 Kuopio, Finland.
C3 Kuopio University Hospital; Central Finland Central Hospital; University
   of Oulu; University of Oulu; University of Eastern Finland; Kuopio
   University Hospital; Research Council of Finland; University of Eastern
   Finland
RP Koponen, H (corresponding author), Kuopio Univ Hosp, Dept Psychiat, POB 1777, FIN-70211 Kuopio, Finland.
EM hannujuhani.koponen@uku.fi
OI Jokelainen, Jari/0000-0003-4629-0560
FU Central Finland Hospital District; Academy of Finland [113 760]
FX This work was supported by grant from the Central Finland Hospital
   District (MV), and grant number 113 760 from the Academy of Finland
   (HK).
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NR 33
TC 81
Z9 86
U1 0
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0001-690X
EI 1600-0447
J9 ACTA PSYCHIAT SCAND
JI Acta Psychiatr. Scand.
PD FEB
PY 2009
VL 119
IS 2
BP 137
EP 142
DI 10.1111/j.1600-0447.2008.01283.x
PG 6
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 394MB
UT WOS:000262449700006
PM 19016666
DA 2025-06-11
ER

PT J
AU Hjort, A
   Iggman, D
   Rosqvist, F
AF Hjort, Anna
   Iggman, David
   Rosqvist, Fredrik
TI Glycemic variability assessed using continuous glucose monitoring in
   individuals without diabetes and associations with cardiometabolic risk
   markers: A systematic review and meta-analysis
SO CLINICAL NUTRITION
LA English
DT Review
DE Atherosclerosis; Cardiovascular disease; Continuous glucose monitoring;
   Glycemic variability; Prediabetes; Type 2 diabetes
ID BLOOD-PRESSURE VARIABILITY; CORONARY-ARTERY-DISEASE; OXIDATIVE STRESS;
   ENDOTHELIAL FUNCTION; PLAQUE VULNERABILITY; INSULIN-RESISTANCE;
   METABOLIC SYNDROME; OBESE; FLUCTUATIONS; IMPACT
AB Background & aims: Continuous glucose monitoring (CGM) provides data on short-term glycemic variability (GV). GV is associated with adverse outcomes in individuals with diabetes. Whether GV is associated with cardiometabolic risk in individuals without diabetes is unclear. We systematically reviewed the literature to assess whether GV is associated with cardiometabolic risk markers or outcomes in individuals without diabetes. Methods: Searches were performed in PubMed/Medline, Embase and Cochrane from inception through April 2022. Two researchers were involved in study selection, data extraction and quality assessment. Studies evaluating GV using CGM for >= 24 h were included. Studies in populations with acute and/or critical illness were excluded. Both narrative synthesis and meta -analyzes were performed, depending on outcome. Results: Seventy-one studies were included; the majority were cross-sectional. Multiple measures of GV are higher in individuals with compared to without prediabetes and GV appears to be inversely associated with beta cell function. In contrast, GV is not clearly associated with insulin sensitivity, fatty liver disease, adiposity, blood lipids, blood pressure or oxidative stress. However, GV may be positively associated with the degree of atherosclerosis and cardiovascular events in individuals with coronary disease. Conclusion: GV is elevated in prediabetes, potentially related to beta cell dysfunction, but less clearly associated with obesity or traditional risk factors. GV is associated with coronary atherosclerosis development and may predict cardiovascular events and type 2 diabetes. Prospective studies are warranted, investigating the predictive power of GV in relation to incident disease. GV may be an important risk measure also in individuals without diabetes. (c) 2024 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
C1 [Hjort, Anna] Chalmers Univ Technol, Dept Biol & Biol Engn, Div Food & Nutr Sci, Kemivagen 10, S-41296 Gothenburg, Sweden.
   [Iggman, David] Uppsala Univ, Ctr Clin Res Dalarna, Nissersvag 3, S-79182 Falun, Sweden.
   [Iggman, David; Rosqvist, Fredrik] Uppsala Univ, Dept Publ Hlth & Caring Sci Clin Nutr & Metab, Husargatan 3,BMC,Box 564, S-75122 Uppsala, Sweden.
C3 Chalmers University of Technology; Uppsala University; Uppsala
   University
RP Rosqvist, F (corresponding author), Uppsala Univ, Dept Publ Hlth & Caring Sci Clin Nutr & Metab, Husargatan 3,BMC,Box 564, S-75122 Uppsala, Sweden.
EM anna.hjort@chalmers.se; David.iggman@regiondalarna.se;
   Fredrik.rosqvist@pubcare.uu.se
RI Rosqvist, Fredrik/K-8975-2019; Iggman, David/AFF-3035-2022
OI Iggman, David/0000-0002-6281-7441
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NR 105
TC 13
Z9 13
U1 0
U2 6
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0261-5614
EI 1532-1983
J9 CLIN NUTR
JI Clin. Nutr.
PD APR
PY 2024
VL 43
IS 4
BP 915
EP 925
DI 10.1016/j.clnu.2024.02.014
EA FEB 2024
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA NH0N4
UT WOS:001199443700001
PM 38401227
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Andrade, C
AF Andrade, Chittaranjan
TI Cardiometabolic Risks in Schizophrenia and Directions for Intervention,
   2: Nonpharmacological Interventions
SO JOURNAL OF CLINICAL PSYCHIATRY
LA English
DT Article
DE Metabolic Disorders; Psychopharmacology; Schizophrenia
ID SERIOUS MENTAL-ILLNESS; CARDIOVASCULAR-DISEASE; METAANALYSIS; ADULTS;
   MORTALITY
AB Patients with schizophrenia have increased prevalence rates for many cardiometabolic risks, including the metabolic syndrome, and an increased risk of adverse cardiovascular events, including mortality. Behavioral interventions such as diet and exercise (separately and together) improve physical health outcomes in the general population. There are no studies on dietary guidance as a sole behavioral intervention for patients with schizophrenia. A meta-analysis found that exercise as a sole behavioral intervention does not result in meaningful physical or mental health gains in patients with major mental illness. Another meta-analysis found that combined diet and exercise, along with other behavioral elements, was associated with statistically significant but modest weight reduction (mean = 3.14 kg) in the short to intermediate term, but with no other cardiometabolic risk factor benefits. A large, well-supervised, pragmatic, 1-year randomized controlled trial found that behavioral interventions were not associated with health gains on a 10-year cardiovascular risk index, or on a large range of indices of physical and mental health. An added concern is that patients with schizophrenia are poorly motivated for behavioral interventions and show poor participation in such interventions. Barriers, and means of overcoming these barriers, have been identified for the implementation of behavioral programs to improve physical health in patients with serious mental illness. It remains to be demonstrated, however, that behavioral intervention programs consistently improve cardiovascular health indices in patients with schizophrenia and other major mental illnesses. (C) Copyright 2016 Physicians Postgraduate Press, Inc.
C1 [Andrade, Chittaranjan] Natl Inst Mental Hlth & Neurosci, Dept Psychopharmacol, Bangalore, Karnataka, India.
C3 National Institute of Mental Health & Neurosciences - India
RP Andrade, C (corresponding author), Natl Inst Mental Hlth & Neurosci, Dept Psychopharmacol, Bangalore, Karnataka, India.
EM candrade@psychiatrist.com
CR Andrade C, 2016, J CLIN PSYCHIAT, V77, pE844, DOI 10.4088/JCP.16f10997
   [Anonymous], COCHRANE DATABASE SY
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NR 19
TC 7
Z9 7
U1 0
U2 5
PU PHYSICIANS POSTGRADUATE PRESS
PI MEMPHIS
PA P O BOX 752870, MEMPHIS, TN 38175-2870 USA
SN 0160-6689
EI 1555-2101
J9 J CLIN PSYCHIAT
JI J. Clin. Psychiatry
PD AUG
PY 2016
VL 77
IS 8
BP E964
EP E967
DI 10.4088/JCP.16f11060
PG 4
WC Psychology, Clinical; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA DY0OO
UT WOS:000384796300001
PM 27561152
OA Bronze
DA 2025-06-11
ER

PT J
AU Zhao, BB
   Chen, LL
   Long, QH
   Xie, GJ
   Xu, B
   Li, ZF
   Wang, P
   Li, HM
AF Zhao, Bin-Bin
   Chen, Lin-Lin
   Long, Qing-Hua
   Xie, Guang-Jing
   Xu, Bo
   Li, Ze-Fei
   Wang, Ping
   Li, Hanmin
TI Preventive Effects of Escitalopram Against Anxiety-Like Depressive
   Behaviors in Monosodium Glutamate-Teated Rats Subjected to Partial
   Hepatectomy
SO FRONTIERS IN PSYCHOLOGY
LA English
DT Article
DE partial hepatectomy; MSG C PH-treated rats; orbitofrontal cortex;
   anxiety-like depressive behaviors; Nissl body and neurites; hepatic
   steatosis; neurotransmitters
ID PRO-INFLAMMATORY CYTOKINES; METABOLIC SYNDROME; MAJOR DEPRESSION;
   LIVER-DISEASE; ADIPOSE-TISSUE; STRESS; REGENERATION; INVOLVEMENT;
   EXPRESSION
AB The reasons for the relationship between depression and chronic liver disease (CLD) are complex and multifactorial. Further research is needed to decipher the etiology and establish an optimal management approach for depression in patients, including the potential role of non-pharmacological treatments. monosodium glutamate (MSG)-treated rats are more likely to develop anxiogenic- and depressive-like behaviors, which could be related to the dysfunction of serotonergic system. In this study, partial hepatectomy (PH) was performed in MSG-treated rats and the histopathological changes were observed in orbitofrontal cortex (OFC) and liver. The effect of escitalopram, a widely used antidepressant, on neural and liver injury in this model was also examined. The MSG C PH-treated rats displayed decreased distances traveled in total, in center arena, and in the left side of arena in inner open field test (OFT), as compared to saline, saline C PH, and MSG-treated animals. The present study established that PH aggravated anxiety-like depressive behaviors in MSG-treated rats, concordant with damaged Nissl bodies (and neurites), decreased IBA-1 and Sox-2 expression in OFC and neurotransmitter disorder. Escitalopram treatment could alleviate these pathological changes as well as reduce hepatic steatosis and lipid metabolism.
C1 [Zhao, Bin-Bin; Chen, Lin-Lin; Long, Qing-Hua; Xie, Guang-Jing; Xu, Bo; Li, Ze-Fei; Wang, Ping] Hubei Univ Chinese Med, Wuhan, Peoples R China.
   [Li, Hanmin] Hubei Univ Chinese Med, Hubei Hosp Tradit Chinese Med, Affiliated Hosp, Hubei Univ Tradit Chinese Med, Wuhan, Peoples R China.
C3 Hubei University of Chinese Medicine; Hubei University of Chinese
   Medicine
RP Wang, P (corresponding author), Hubei Univ Chinese Med, Wuhan, Peoples R China.; Li, HM (corresponding author), Hubei Univ Chinese Med, Hubei Hosp Tradit Chinese Med, Affiliated Hosp, Hubei Univ Tradit Chinese Med, Wuhan, Peoples R China.
EM pwang54@aliyun.com; lihanmin69@126.com
RI Wang, Ping/MGT-4077-2025
FU National Natural Science Foundation of China [81703973, 90709041,
   81373513, 81603484, 81703912]; National Key R&D Program of China
   [2018YFC1705600]; Business Construction Research Project of National TCM
   Clinical Research Base by National Administration of Traditional Chinese
   Medicine [JDZX2015172]; Young Talent Project of Scientific Research Plan
   of Education Department in Hubei Province [Q20172003]; Young Seedling
   Plan of Hubei University of Chinese Medicine [2016-224]; Hubei
   University of Chinese Medicine Introduction of High-level Talent Plan
   [5114100724]; National Famous Old Chinese Medicine Experts Inheritance
   Studio
FX We acknowledge financial support from the National Natural Science
   Foundation of China (Nos. 81703973, 90709041, 81373513, 81603484, and
   81703912), National Key R&D Program of China (2018YFC1705600), the
   Business Construction Research Project of National TCM Clinical Research
   Base by National Administration of Traditional Chinese Medicine
   (JDZX2015172), the Young Talent Project of Scientific Research Plan of
   Education Department in Hubei Province (Q20172003), the Young Seedling
   Plan of Hubei University of Chinese Medicine (2016-224), and the Hubei
   University of Chinese Medicine Introduction of High-level Talent Plan
   (5114100724). HL National Famous Old Chinese Medicine Experts
   Inheritance Studio.
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TC 4
Z9 5
U1 0
U2 24
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-1078
J9 FRONT PSYCHOL
JI Front. Psychol.
PD NOV 12
PY 2019
VL 10
AR 2462
DI 10.3389/fpsyg.2019.02462
PG 10
WC Psychology, Multidisciplinary
WE Social Science Citation Index (SSCI)
SC Psychology
GA OQ2XK
UT WOS:000588652000001
PM 31798487
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Gao, Y
   Li, WJ
   Huang, XY
   Lyu, Y
   Yue, CW
AF Gao, Yu
   Li, Wujuan
   Huang, Xiaoyu
   Lyu, Yuhong
   Yue, Changwu
TI Advances in Gut Microbiota-Targeted Therapeutics for Metabolic Syndrome
SO MICROORGANISMS
LA English
DT Review
DE gut microbiome; metabolic syndrome; probiotics; prebiotics; dysbiosis
ID RANDOMIZED DOUBLE-BLIND; BLOOD-PRESSURE; OBESITY; TRANSPLANTATION;
   SUPPLEMENTATION
AB Previous investigations have illuminated the significant association between the gut microbiome and a broad spectrum of health conditions, including obesity, diabetes, cardiovascular diseases, and psychiatric disorders. Evidence from certain studies suggests that dysbiosis of the gut microbiota may play a role in the etiology of obesity and diabetes. Moreover, it is acknowledged that dietary habits, pharmacological interventions, psychological stress, and other exogenous factors can substantially influence the gut microbial composition. For instance, a diet rich in fiber has been demonstrated to increase the population of beneficial bacteria, whereas the consumption of antibiotics can reduce these advantageous microbial communities. In light of the established correlation between the gut microbiome and various pathologies, strategically altering the gut microbial profile represents an emerging therapeutic approach. This can be accomplished through the administration of probiotics or prebiotics, which aim to refine the gut microbiota and, consequently, mitigate the manifestations of associated diseases. The present manuscript evaluates the recent literature on the relationship between gut microbiota and metabolic syndrome published over the past three years and anticipates future directions in this evolving field.
C1 [Gao, Yu; Li, Wujuan; Huang, Xiaoyu; Lyu, Yuhong; Yue, Changwu] Yanan Univ, Sch Basic Med, Yanan Key Lab Microbial Drug Innovat & Transformat, Yanan 716000, Peoples R China.
   [Lyu, Yuhong; Yue, Changwu] Yanan Univ, Shaanxi Engn & Technol Res Ctr Conversat & Utiliza, Yanan 716000, Peoples R China.
C3 Yanan University; Yanan University
RP Yue, CW (corresponding author), Yanan Univ, Sch Basic Med, Yanan Key Lab Microbial Drug Innovat & Transformat, Yanan 716000, Peoples R China.; Yue, CW (corresponding author), Yanan Univ, Shaanxi Engn & Technol Res Ctr Conversat & Utiliza, Yanan 716000, Peoples R China.
EM gy944013192@163.com; lwj2117101041@163.com; suiyu21@outlook.com;
   yuhonglyu@126.com; changwuyue@yau.edu.cn
RI 高, 宇/HKN-1540-2023
OI yue, Changwu/0000-0003-2679-5772
FU Yan'an University Qin Chuanyuan "Scientist + Engineer" team Special
FX No Statement Available
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NR 69
TC 5
Z9 5
U1 4
U2 8
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-2607
J9 MICROORGANISMS
JI Microorganisms
PD MAY
PY 2024
VL 12
IS 5
AR 851
DI 10.3390/microorganisms12050851
PG 14
WC Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Microbiology
GA SA0E6
UT WOS:001231614800001
PM 38792681
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Lepe, A
   Reijneveld, SA
   Almansa, J
   De Winter, AF
   De Kroon, MLA
AF Lepe, Alexander
   Reijneveld, Sijmen A.
   Almansa, Josue
   de Winter, Andrea F.
   de Kroon, Marlou L. A.
TI Socioeconomic Health Inequalities in Adolescent Metabolic Syndrome and
   Depression: No Mediation by Parental Depression and Parenting Style
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Article
DE health inequalities; adolescents; public health; epidemiology; cohort
   studies; socioeconomic status; metabolic syndrome; depression
ID RISK-FACTORS; BEHAVIORS; DISEASES; STRESS
AB We assessed to what extent parental depression and parenting style mediate the relationships between different measures of parental socioeconomic status (SES) and both depression and metabolic syndrome (MetS) in adolescents, and whether sex moderates these mechanisms. Data were from the prospective multigenerational Dutch Lifelines Cohort Study. Our sample consisted of 1217 adolescents with an average follow-up of 33.3 (SD = 7.33) months and a median baseline age of 13 (IQR:13-14) years. We used structural equation models to assess the direct and indirect effects of SES on baseline and changes at follow-up in both depression and MetS, and to assess moderation by sex. For each additional year of education, continuous MetS scores were 0.098 (95%CI: 0.020; 0.184) units lower at baseline and decreased 0.079 (95%CI: 0.004; 0.158) units at follow-up. No other direct or indirect effects of SES were found, and there was no moderation by sex. Additionally, warmer parenting style was generally associated with more favorable outcome scores. Therefore, improving parenting style may improve health for all adolescents. However, in this study parental depression and parenting style did not account for adolescent socioeconomic health inequalities. This may be partly due to good access to social services within the Netherlands.
C1 [Lepe, Alexander; Reijneveld, Sijmen A.; Almansa, Josue; de Winter, Andrea F.; de Kroon, Marlou L. A.] Univ Groningen, Univ Med Ctr Groningen, Dept Hlth Sci, NL-9713 GZ Groningen, Netherlands.
C3 University of Groningen
RP Lepe, A (corresponding author), Univ Groningen, Univ Med Ctr Groningen, Dept Hlth Sci, NL-9713 GZ Groningen, Netherlands.
EM a.lepe@umcg.nl; s.a.reijneveld@umcg.nl; j.almansa.ortiz@umcg.nl;
   a.f.de.winter@umcg.nl; m.l.a.de.kroon@umcg.nl
RI Lepe, Alexander/IXD-2398-2023; de Kroon, Marlou/M-4040-2014; Almansa,
   Josue/J-4503-2019
OI Reijneveld, Sijmen/0000-0002-1206-7523; Lepe,
   Alexander/0000-0001-7593-4770; Almansa, Josue/0000-0001-9724-9328; de
   Kroon, Marlou/0000-0003-1730-4994
FU ZonMw [531003011]
FX This study is part of the TRANSSES project which is funded by ZonMw
   (Grant 531003011). The funders had no role in the design of the study;
   in the collection, analyses, or interpretation of data; in the writing
   of the manuscript, or in the decision to publish the results.
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NR 39
TC 4
Z9 4
U1 3
U2 20
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD JUL
PY 2021
VL 18
IS 14
AR 7716
DI 10.3390/ijerph18147716
PG 12
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA TN5UW
UT WOS:000676300400001
PM 34300166
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Khoei, NS
   Wagner, KH
   Sedlmeier, AM
   Gunter, MJ
   Murphy, N
   Freisling, H
AF Seyed Khoei, Nazlisadat
   Wagner, Karl-Heinz
   Sedlmeier, Anja M.
   Gunter, Marc J.
   Murphy, Neil
   Freisling, Heinz
TI Bilirubin as an indicator of cardiometabolic health: a cross-sectional
   analysis in the UK Biobank
SO CARDIOVASCULAR DIABETOLOGY
LA English
DT Article
DE Bilirubin; Metabolic syndrome; Obesity; UK Biobank
ID MIDDLE-AGED ADULTS; SERUM BILIRUBIN; METABOLIC SYNDROME;
   CARDIOVASCULAR-DISEASE; GILBERTS-SYNDROME; OXIDATIVE STRESS;
   ADIPOSE-TISSUE; ASSOCIATION; LIPOPROTEIN; RISK
AB Background Mildly elevated bilirubin, a by-product of hemoglobin breakdown, might mitigate cardiometabolic risk factors including adiposity, dyslipidemia, and high blood pressure (BP). We investigated the cross-sectional relationship between (total) bilirubin and baseline cardiometabolic risk factors in 467,519 UK Biobank study participants. Methods We used multivariable-adjusted linear regression to estimate associations between bilirubin levels and risk factors of cardiometabolic diseases including body mass index (BMI), waist and hip circumferences (WC, HC), waist-to-hip ratio (WHR), fat mass (FM), and trunk FM, and the blood lipids: apolipoprotein A-I (apoA-I), apolipoprotein B (apoB), apoB/apoA-I, lipoprotein (a), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), LDL/HDL, TC/HDL, triglycerides (TG). Log-transformed bilirubin was modelled with restricted cubic splines and predicted mean values with 99% confidence intervals (CI) for each risk marker were estimated, separately. Second, we applied principal component analysis (PCA) for dimension reduction to in turn six anthropometric traits (height, weight, BMI, WC, HC, and WHR) and all above lipids. Last, we estimated associations (99%CI) between bilirubin and three components of the metabolic syndrome, i.e. WC, TG, and BP using logistic regression. Results After multivariable adjustments, higher levels of bilirubin were inversely associated with indicators of general adiposity (BMI and FM) and of body fat distribution (WC, HC, WHR, and trunk FM) in both men and women. For example, women with mildly elevated bilirubin (95(th) percentile equal to 15.0 mu mol/L), compared to women with low bilirubin (5(th) percentile equal to 4.5 mu mol/L), had on average a 2.0 kg/m(2) (99% CI 1.9-2.1) lower BMI. Inverse associations were also observed with dyslipidemia among men and women. For example, mildly elevated bilirubin among men (95(th) percentile equal to 19.4 mu mol/L) compared to low levels of bilirubin (5(th) percentile equal to 5.5 mu mol/L) were associated with approx. 0.55 mmol/L (99% CI 0.53-0.56) lower TG levels, with similar inverse associations among women. Multiple-trait analyses using PCA confirmed single-trait analyses. Men and women with mildly elevated bilirubin levels >= 17.1 mu mol/L, compared to low-normal bilirubin < 10 mu mol/L had 13% (99% CI 8%-18%) and 11% (99% CI 4%-17%) lower odds of exceeding systolic BP levels of >= 130 mm Hg, respectively. Conclusions Higher levels of bilirubin were inversely associated with cardiometabolic risk factors including adiposity, dyslipidemia, and hypertension.
C1 [Seyed Khoei, Nazlisadat; Wagner, Karl-Heinz] Univ Vienna, Fac Life Sci & Res Platform Act Ageing, Dept Nutr Sci, Althanstr 14, A-1090 Vienna, Austria.
   [Sedlmeier, Anja M.] Univ Regensburg, Dept Epidemiol & Prevent Med, Franz Josef Strauss Allee 11, D-93053 Regensburg, Germany.
   [Gunter, Marc J.; Murphy, Neil; Freisling, Heinz] Int Agcy Res Canc IARC WHO, Nutr & Metab Branch, 150 Cours Albert Thomas, F-69372 Lyon 08, France.
C3 University of Vienna; University of Regensburg; World Health
   Organization; International Agency for Research on Cancer (IARC)
RP Freisling, H (corresponding author), Int Agcy Res Canc IARC WHO, Nutr & Metab Branch, 150 Cours Albert Thomas, F-69372 Lyon 08, France.
EM Freislingh@iarc.fr
RI Murphy, Neil/E-1189-2017; Gunter, Marc/AAP-8621-2020; Wagner,
   Karl-Heinz/B-9098-2013
OI Seyed Khoei, Nazlisadat/0000-0001-6003-7794; Wagner,
   Karl-Heinz/0000-0002-1683-7265
FU Austrian Science Fund (FWF) [P 32303]
FX This work was supported by the Austrian Science Fund (FWF, Grant No. P
   32303).
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NR 56
TC 18
Z9 18
U1 2
U2 10
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1475-2840
J9 CARDIOVASC DIABETOL
JI Cardiovasc. Diabetol.
PD APR 18
PY 2022
VL 21
IS 1
AR 54
DI 10.1186/s12933-022-01484-x
PG 13
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism
GA 0O4CU
UT WOS:000783476000001
PM 35436955
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Martocchia, A
   Stefanelli, M
   Gallucci, M
   Noale, M
   Maggi, S
   Cassol, M
   Postacchini, D
   Proietti, A
   Barbagallo, M
   Dominguez, LJ
   Ferri, C
   Desideri, G
   Toussan, L
   Pastore, F
   Falaschi, GM
   Paolisso, G
   Falaschi, P
AF Martocchia, Antonio
   Stefanelli, Manuela
   Gallucci, Maurizio
   Noale, Marianna
   Maggi, Stefania
   Cassol, Maurizio
   Postacchini, Demetrio
   Proietti, Antonella
   Barbagallo, Mario
   Dominguez, Ligia J.
   Ferri, Claudio
   Desideri, Giovambattista
   Toussan, Lavinia
   Pastore, Francesca
   Falaschi, Giulia M.
   Paolisso, Giuseppe
   Falaschi, Paolo
TI Increased nocturnal urinary cortisol levels in the elderly patients with
   depression, coexisting major geriatric syndromes and combined
   pathogenetic mechanisms
SO AGING CLINICAL AND EXPERIMENTAL RESEARCH
LA English
DT Article
DE Cortisol; Aging; Depression; Dementia; Metabolic syndrome
ID MINI-MENTAL-STATE; COGNITIVE IMPAIRMENT; METABOLIC SYNDROME; ALLOSTATIC
   LOAD; SYMPTOMS; RISK; DEMENTIA; BIOMARKERS; ILLNESS; FRAILTY
AB Background The mechanisms at the basis of depression are still matter of debate, but several studies in the literature suggest common pathways with dementia (genetic predispositions, metabolic and inflammatory mechanisms, neuropathological changes) and other geriatric syndromes. Aims To evaluate the role of cortisol (as marker of the HPA, hypothalamus-pituitary-adrenal axis hyperactivity) in elderly subjects with depressive symptoms (by the means of the AGICO, AGIng and COrtisol, study), in relationship to the presence of the major geriatric syndromes. Methods The AGICO study enrolled patients from ten Geriatric Units in Italy. Every subject received a comprehensive geriatric assessment or CGA (including the Mini Mental State Examination or MMSE, Geriatric Depression Scale or GDS and Cornell Scale for Depression in Dementia or CSDD), the neurological examination (with a computed tomography scan or magnetic resonance imaging of the brain), the assessment of the metabolic syndrome (MetS), the evaluation of the cortisol activity by two consecutive urine collections (diurnal and nocturnal), a CGA-derived frailty index (FI) and a modified measure of allostatic load (AL). Results The MMSE scores were significantly and inversely related to the values of GDS (p < 0.001) and CSDD (p < 0.05), respectively. The patients with depressive symptoms (GDS/CSDD > 8) showed significantly increased disability, MetS, inflammation, FI and AL and significantly reduced MMSE and renal function.The diurnal and nocturnal urinary cortisol levels in the patients with depressive symptoms (GDS/CSDD > 8) were higher with respects to controls (p < 0.05 for nocturnal difference). Discussion The AGICO study showed that the stress response is activated in the patients with depression. Conclusion The depression in elderly patient should be reconsidered as a systemic disease, with coexisting major geriatric syndromes (disability, dementia, frailty) and combined pathogenetic mechanisms (metabolic syndrome, impaired renal function, low-grade inflammation, and allostatic load). Cortisol confirmed its role as principal mediator of the aging process in both dementia and metabolic syndrome.
C1 [Martocchia, Antonio; Stefanelli, Manuela; Proietti, Antonella; Toussan, Lavinia; Falaschi, Giulia M.; Falaschi, Paolo] Sapienza Univ Rome, S Andrea Hosp, Via Grottarossa 1035, I-00189 Rome, Italy.
   [Stefanelli, Manuela] Casa Cura Villa Domelia, Rome, Italy.
   [Gallucci, Maurizio] Cognit Impairment Ctr, Local Unit Hlth & Social Serv 2, Treviso, Italy.
   [Noale, Marianna; Maggi, Stefania] Natl Res Council CNR, Neurosci Inst, Aging Branch, Padua, Italy.
   [Cassol, Maurizio] S Pietro Fatebenefratelli Hosp, Rome, Italy.
   [Postacchini, Demetrio] Italian Natl Res Ctr Aging IRCCS INRCA, Geriatr Operat Unit, Fermo, Italy.
   [Barbagallo, Mario; Dominguez, Ligia J.] Univ Palermo, Dept Med, Geriatr Unit, Palermo, Italy.
   [Ferri, Claudio] Univ Aquila, Dept Clin Med Life Hlth & Environm Sci, Laquila, Italy.
   [Desideri, Giovambattista] Sapienza Univ Rome, Dept Clin Internal Anesthesiol & Cardiovasc Sci, Rome, Italy.
   [Toussan, Lavinia] RSA Anni Azzurri Parco Veio, Rome, Italy.
   [Pastore, Francesca] Kos Care Villa Margher, Benevento, Italy.
   [Paolisso, Giuseppe] Univ Campania Luigi Vanvitelli, Dept Adv Med & Surg Sci, Naples, Italy.
C3 Sapienza University Rome; Azienda Ospedaliera Sant'Andrea; University of
   Palermo; University of L'Aquila; Sapienza University Rome; Universita
   della Campania Vanvitelli
RP Martocchia, A (corresponding author), Sapienza Univ Rome, S Andrea Hosp, Via Grottarossa 1035, I-00189 Rome, Italy.
EM antonio.martocchia@uniroma1.it
RI BARBAGALLO, MARIO/K-4794-2017; Barbara, C./AAF-3397-2020; Noale,
   Marianna/IXD-2540-2023
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NR 50
TC 0
Z9 0
U1 1
U2 3
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1594-0667
EI 1720-8319
J9 AGING CLIN EXP RES
JI Aging Clin. Exp. Res.
PD SEP 27
PY 2024
VL 36
IS 1
AR 196
DI 10.1007/s40520-024-02849-w
PG 8
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA H6S9D
UT WOS:001324730200001
PM 39331197
OA hybrid
DA 2025-06-11
ER

PT J
AU Tongo, SY
   Longo-Mbenza, B
   Aundu, AM
   Gombet, R
   Risasi, JRM
   Lusunsi, CK
   Malengele, HM
   Okwe, AN
AF Tongo, Stephane Yanda
   Longo-Mbenza, Benjamin
   Aundu, Antoine Molua
   Gombet, Raoul
   Risasi, Jean Robert Makulo
   Lusunsi, Christian Kisoka
   Malengele, Heritier Mawalala
   Okwe, Augustin Nge
TI Are Any Changes in Carotid Intima-Media Thickness Associated with
   Cardiometabolic Risk Among Adult Bantu Central African Hypertensive
   Patients from Monkole and Biamba Marie Mutombo Hospitals?
SO VASCULAR HEALTH AND RISK MANAGEMENT
LA English
DT Article
DE carotid intima-media thickness; subclinical atherosclerosis; Central
   Africans
ID NONCOMMUNICABLE DISEASES; CARDIOVASCULAR-DISEASE; GLOBAL BURDEN;
   DETERMINANTS; CHOLESTEROL; INCOME
AB Background: Several classic/traditional risk factors are associated with intima-media thickness (IMT), a novel risk of cardio metabolic risk (CMR) in the literature but not in Kinshasa, a megacity prone to CMR. Thus, the objective of this study was to evaluate potential correlations between inflammation, kidney function, psychological stress, hemodynamics, and changes in IMT. Methods: This cross-sectional study was carried out between 2018 and 2021 within Monkole and Biamba Marie Mutombo Hospitals, respectively, and randomly selected from 10 health structures from East and West of Kinshasa, Capital of Democratic Republic Congo (DRC). A random sample of adult hypertensive Bantu Central Africans was examined after bivariate correlations and multiple linear regression. Results: Out of 280 patients with 140 men and 140 women aged 62 +/- 11 years, the mean carotid intima-media thickness (CIMT) was 1.06 +/- 0.5 mm and 73% (n = 204) patients had uncontrolled hypertension. After controlling for confounders, 52.9% variations (R2) of CIMT were independently and significantly (P = 0.037) predicted by CRP, 24-hour proteinuria, urinary albumin/creatinine ratio, duration of hypertension, heart rate, hip circumference, and psychological stress with Equation Y = 0.717 + 0.87 x CRP + 0.02 x 24 H - proteinuria + 0.005 x urinary albumin/creatinine ratio + 0.05 x duration of hypertension + 0.001 x heart rate + 0.006 x hip circumference + 0.017 x psychological stress. Conclusion: There is an urgent need to control inflammation, impaired renal function, cardiac rhythm, peripheral obesity, longer duration of hypertension management, and stress, which are emerging as specific novel determinants of the subclinical atherosclerosis for those Bantu Central African hypertensive patients.
C1 [Tongo, Stephane Yanda; Aundu, Antoine Molua; Malengele, Heritier Mawalala] Clin Univ Kinshasa, Radiol Serv, Kinshasa, DEM REP CONGO.
   [Longo-Mbenza, Benjamin] Clin Univ Kinshasa, Cardiol Serv, Kinshasa, DEM REP CONGO.
   [Longo-Mbenza, Benjamin; Lusunsi, Christian Kisoka; Okwe, Augustin Nge] Lomo Univ Res, Dept Publ Hlth, Kinshasa, DEM REP CONGO.
   [Gombet, Raoul] Marien Ngouabi Univ, Brazzaville, Rep Congo.
   [Risasi, Jean Robert Makulo] Clin Univ Kinshasa, Nephrol Serv, Kinshasa, DEM REP CONGO.
C3 Universite de Kinshasa; Universite de Kinshasa; Universite de Kinshasa
RP Longo-Mbenza, B (corresponding author), Fac Hlth Sci, Private Bay 11, ZA-5117 Mthatha, Eastern Cape, South Africa.
EM longombenza@gmail.com
OI MAKULO, Jean-Robert/0000-0001-5517-3281; Kisoka Lusunsi,
   Christian/0000-0002-0576-841X
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NR 61
TC 2
Z9 2
U1 0
U2 4
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1176-6344
EI 1178-2048
J9 VASC HEALTH RISK MAN
JI Vasc. Health Risk Manag.
PY 2022
VL 18
DI 10.2147/VHRM.S366339
PG 9
WC Peripheral Vascular Disease
WE Emerging Sources Citation Index (ESCI)
SC Cardiovascular System & Cardiology
GA 2T2KI
UT WOS:000822306700001
PM 35800291
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Velligan, DI
   Castillo, D
   Lopez, L
   Manaugh, B
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   Dassori, A
   Miller, AL
AF Velligan, Dawn I.
   Castillo, Desiree
   Lopez, Linda
   Manaugh, Bren
   Davis, Charlotte
   Rodriguez, Juanita
   Milam, A. Camis
   Dassori, Albana
   Miller, Alexander L.
TI A Case Control Study of the Implementation of Change Model Versus
   Passive Dissemination of Practice Guidelines for Compliance in
   Monitoring for Metabolic Syndrome
SO COMMUNITY MENTAL HEALTH JOURNAL
LA English
DT Article
DE Metabolic syndrome monitoring; Practice guidelines; Community mental
   health; Atypical antipsychotics; Implementation of change model; Serious
   mental illness
ID ANTIPSYCHOTIC MEDICATIONS; VENOUS THROMBOEMBOLISM; HEALTH-CARE;
   SCHIZOPHRENIA; STATEMENT; CATIE; RISK
AB We developed an intervention to improve compliance with guidelines for monitoring metabolic syndrome and compared compliance prior to intervention and three times post-intervention at three community mental health clinics in Texas. One test clinic received intervention and two other clinics served as controls. Fifty random charts were reviewed from each clinic for three specific, 1-2 weeks periods over the course of 18 months. There were significant improvements in the ordering of labs, the presence of lab results in the chart, and documentation of blood pressure, body mass index and waist circumference in the intervention clinic over time in comparison to the control clinics. Documented evidence of physician action with respect to out of range values remained low. Metabolic monitoring is a multi-step process. Removing barriers, creating specific procedures, and dedicating staff resources can improve compliance with monitoring.
C1 [Velligan, Dawn I.; Castillo, Desiree; Milam, A. Camis; Miller, Alexander L.] Univ Texas Hlth Sci Ctr San Antonio, Dept Psychiat, San Antonio, TX 78229 USA.
   [Lopez, Linda; Manaugh, Bren; Davis, Charlotte; Rodriguez, Juanita; Milam, A. Camis] Ctr Hlth Care Serv, Bexar Cty, TX USA.
   [Dassori, Albana] Audie L Murphy Mem Vet Adm Med Ctr, San Antonio, TX 78284 USA.
C3 University of Texas System; University of Texas Health Science Center at
   San Antonio; US Department of Veterans Affairs; Veterans Health
   Administration (VHA); Audie L. Murphy Memorial Veterans Hospital
RP Velligan, DI (corresponding author), Univ Texas Hlth Sci Ctr San Antonio, Dept Psychiat, Mail Stop 7797,7703 Floyd Curl Dr, San Antonio, TX 78229 USA.
EM velligand@uthscsa.edu; castillod@uthscsa.edu; LLopez@chcsbc.org;
   BManaugh@chcsbc.org; Cdavis@chscbc.org; jlrodriguez@chcsbc.org;
   milama@uthscsa.edu; millera@uthscsa.edu
FU NIMH NIH HHS [R24 MH072830] Funding Source: Medline
CR Cabana MD, 1999, JAMA-J AM MED ASSOC, V282, P1458, DOI 10.1001/jama.282.15.1458
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NR 18
TC 7
Z9 9
U1 0
U2 8
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0010-3853
J9 COMMUNITY MENT HLT J
JI Community Ment. Health J.
PD APR
PY 2013
VL 49
IS 2
BP 141
EP 149
DI 10.1007/s10597-011-9472-z
PG 9
WC Health Policy & Services; Public, Environmental & Occupational Health;
   Psychiatry
WE Social Science Citation Index (SSCI)
SC Health Care Sciences & Services; Public, Environmental & Occupational
   Health; Psychiatry
GA 136MS
UT WOS:000318366600001
PM 22350562
DA 2025-06-11
ER

PT J
AU Dekker, IP
   Marijnissen, RM
   Giltay, EJ
   van der Mast, RC
   Voshaar, RCO
   Rhebergen, D
   Ottenheim, NR
AF Dekker, Ilse P.
   Marijnissen, Radboud M.
   Giltay, Erik J.
   van der Mast, Roos C.
   Voshaar, Richard C. Oude
   Rhebergen, Didi
   Ottenheim, Nathaly Rius
TI The role of metabolic syndrome in late-life depression over 6 years: The
   NESDO study
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Metabolic syndrome; Depression; Older persons
ID PHYSICAL-ACTIVITY QUESTIONNAIRE; SYMPTOMATOLOGY; RELIABILITY;
   ASSOCIATION; INVENTORY; DISEASE; HEALTH; ADULTS
AB Background: Metabolic syndrome (MetS) has been associated with both early- and late-life depression. This study investigated whether baseline MetS and its individual components are associated with the course of depression over six years among older persons with a formal depression diagnosis.
   Methods: Data were used from 378 older persons with a depressive disorder from the Netherlands Study of Depression in Old age (NESDO) with a 6-year follow-up. A formal depression diagnosis according to DSM-IV-TR criteria was ascertained with the Composite International Diagnostic Interview. Severity of depressive symptoms was assessed with the Inventory of Depressive Symptomatology at 6-month intervals. Metabolic syndrome (MetS) was defined according the modified National Cholesterol Education Programme - Adult Treatment Panel III criteria. Primary outcome was time to remission from depression. We applied cox regression analysis for the primary outcome and linear mixed models for secondary analyses.
   Results: Neither MetS nor its individual components were associated with time to remission from depression (MetS: HR = 1.03; 95% CI = 0.74 - 1.44; p = 0.85), or with depression severity (MetS: B = 0.02; SE = 0.04; p = 0.64) and course of depressive symptoms (MetS: B = -0.01; SE = 0.01; p = 0.23) over 6-years follow-up.
   Limitations: Attrition was relatively high (46.8%). Furthermore, we only had information on formal depression diagnosis at baseline, 2-year, and 6-year follow-up.
   Conclusions: We found no evidence for an effect of baseline presence of metabolic dysregulation on the course of formally diagnosed depression in older persons. Metabolic syndrome in depressed patients should be clinically monitored for other reasons than predicting chronicity or severity of depression.
C1 [Dekker, Ilse P.; Giltay, Erik J.; van der Mast, Roos C.; Ottenheim, Nathaly Rius] Leiden Univ, Dept Psychiat, Med Ctr, Postbus 9600, NL-2300 RC Leiden, Netherlands.
   [Marijnissen, Radboud M.; Voshaar, Richard C. Oude] Univ Groningen, Univ Med Ctr Groningen, Dept Psychiat, Groningen, Netherlands.
   [Marijnissen, Radboud M.; Voshaar, Richard C. Oude] Univ Groningen, Univ Med Ctr Groningen, Interdisciplinary Ctr Psychopathol Emot Regulat, Groningen, Netherlands.
   [Giltay, Erik J.; van der Mast, Roos C.] Univ Antwerp, CAPRI, Antwerp, Belgium.
   [Rhebergen, Didi] Vrije Univ Amsterdam Med Ctr, GGZ inGeest Dept Psychiat, Amsterdam, Netherlands.
   [Rhebergen, Didi] Vrije Univ Amsterdam Med Ctr, Amsterdam Publ Hlth Res Inst, Amsterdam, Netherlands.
C3 Leiden University; Leiden University Medical Center (LUMC); Leiden
   University - Excl LUMC; University of Groningen; University of
   Groningen; University of Antwerp; Vrije Universiteit Amsterdam; VU
   UNIVERSITY MEDICAL CENTER; Vrije Universiteit Amsterdam; VU UNIVERSITY
   MEDICAL CENTER
RP Dekker, IP; Ottenheim, NR (corresponding author), Leiden Univ, Dept Psychiat, Med Ctr, Postbus 9600, NL-2300 RC Leiden, Netherlands.
EM I.P.Dekker@lumc.nl; N.Rius_Ottenheim@lumc.nl
RI Giltay, Erik/AAL-9948-2021
OI Giltay, Erik J./0000-0001-8874-2292; Oude Voshaar,
   Richard/0000-0003-1501-4774
FU Fonds NutsOhra [0701-065]; NARSAD The Brain and Behaviour Research Fund
   [41080]; VU University Medical Centre; Leiden University Medical Centre;
   University Medical Centre Groningen; UMC St Radboud; GGZ inGeest; GGNet;
   GGZ Nijmegen; GGZ Rivierduinen; Lentis; Parnassia; Stichting tot Steun
   VCVGZ
FX The infrastructure for the NESDO study (https://nesdo.onderzoek.io/) is
   funded through the Fonds NutsOhra [project0701-065]; Stichting tot Steun
   VCVGZ, NARSAD The Brain and Behaviour Research Fund [grant ID 41080];
   and the participating universities and mental health care organisations
   (VU University Medical Centre, Leiden University Medical Centre,
   University Medical Centre Groningen, UMC St Radboud, GGZ inGeest, GGNet,
   GGZ Nijmegen, GGZ Rivierduinen, Lentis, and Parnassia).
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NR 35
TC 4
Z9 6
U1 0
U2 4
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD OCT 1
PY 2019
VL 257
BP 735
EP 740
DI 10.1016/j.jad.2019.07.060
PG 6
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA IS8CQ
UT WOS:000482376300092
PM 31386966
OA Green Published
DA 2025-06-11
ER

PT S
AU Yumuk, VD
AF Yumuk, Volkan D.
BE Chrousos, GP
   Tsigos, C
TI Targeting components of the stress system as potential therapies for the
   metabolic syndrome - The peroxisome-proliferator-activated receptors
SO STRESS, OBESITY, AND METABOLIC SYNDROME
SE Annals of the New York Academy of Sciences
LA English
DT Article; Proceedings Paper
CT Bjorntorp Symposium on Stress, Obesity, and Metabolic Syndrome
CY APR 09-10, 2005
CL Athens, GREECE
SP Roche Hellas, Abbott Hellas, Pfizer Hellas, Sanofi Aventis Hellas, GlaxoSmithKline Hellas
DE stress; metabolic syndrome x; peroxisome-proliferator-activated
   receptors; glucocorticoids; 11 beta-hydroxysteroid dehydrogenase
ID TYPE-2 DIABETES-MELLITUS; LIPID-METABOLISM; ADIPOSE-TISSUE; FATTY-ACIDS;
   PPAR-GAMMA; ALPHA GENE; EXPRESSION; TELMISARTAN; BEZAFIBRATE; ADIPOCYTE
AB The three peroxisome-proliferator-activated receptor (PPAR) subtypes PPAR-alpha, PPAR-gamma, and PPAR-delta are ligand-activated transcription factors of the nuclear receptor family. PPARs form obligate heterodimers with the retinoid X receptor, which bind to peroxisome-proliferator-response elements (PPREs). PPAR-alpha is expressed mainly in liver, brown fat, kidney, heart, and skeletal muscle; PPAR-gamma in intestine and adipose tissue; PPAR-alpha and PPAR-gamma are both expressed in vascular endothelium, smooth muscle cells, macrophages, and foam cells; PPAR-delta in skeletal muscle, human embryonic kidney, intestine, heart, adipose tissue, developing brain, and keratinocytes. Intense interest in the development of drugs with new mechanisms of action for the metabolic syndrome has focused attention on nuclear receptors, such as PPARs that function as regulators of energy homeostasis. Agonists of PPAR-a and PPAR-gamma are currently used to treat diabetic dyslipidemia and type 2 diabetes. Dual PPAR-alpha/gamma agonists and PPAR-alpha/gamma/delta pan-agonists are under investigation for treatment of cardiovascular disease and the metabolic syndrome. Selective PPAR modulators (SPPARMs) are PPAR ligands that possess desirable efficacy and improved tolerance. Efforts are being made to identify novel partial agonists or antagonists for PPAR-gamma in order to combine their antidiabetic and antiobesity effects. Glucocorticoids are major mediators of the stress response and could be the link between stress and PPAR activator signaling and thus may affect the downstream metabolic pathways involved in fuel homeostasis.
C1 Istanbul Univ, Cerrahpasa Med Fac, Dept Med, Div Endocrinol & Metab, TR-34303 Cerrahpasa, Turkey.
C3 Istanbul University; Istanbul University - Cerrahpasa
RP Yumuk, VD (corresponding author), Istanbul Univ, Cerrahpasa Med Fac, Dept Med, Div Endocrinol & Metab, TR-34303 Cerrahpasa, Turkey.
EM volkanyumuk@superonline.com
RI Yumuk, Volkan/AAB-6871-2021
OI Yumuk, Volkan Demirhan/0000-0001-6463-4916
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NR 40
TC 20
Z9 23
U1 1
U2 10
PU BLACKWELL SCIENCE PUBL
PI OXFORD
PA OSNEY MEAD, OXFORD OX2 0EL, ENGLAND
SN 0077-8923
BN 978-1-57331-625-5
J9 ANN NY ACAD SCI
JI Ann.NY Acad.Sci.
PY 2006
VL 1083
BP 306
EP 318
DI 10.1196/annals.1367.019
PG 13
WC Endocrinology & Metabolism; Multidisciplinary Sciences
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Science & Technology - Other Topics
GA BFR90
UT WOS:000244102900019
PM 17148746
DA 2025-06-11
ER

PT J
AU Ahola, AJ
   Radzeviciene, L
   Zaharenko, L
   Bulum, T
   Skrebinska, S
   Prakapiene, E
   Blaslov, K
   Roso, V
   Rovite, V
   Pirags, V
   Duvnjak, L
   Sokolovska, J
   Verkauskiene, R
   Forsblom, C
AF Ahola, Aila J.
   Radzeviciene, Lina
   Zaharenko, Linda
   Bulum, Tomislav
   Skrebinska, Sabine
   Prakapiene, Edita
   Blaslov, Kristina
   Roso, Vinko
   Rovite, Vita
   Pirags, Valdis
   Duvnjak, Lea
   Sokolovska, Jelizaveta
   Verkauskiene, Rasa
   Forsblom, Carol
TI Association between symptoms of depression, diabetes complications and
   vascular risk factors in four European cohorts of individuals with type
   1 diabetes - InterDiane Consortium
SO DIABETES RESEARCH AND CLINICAL PRACTICE
LA English
DT Article
DE Depression; Diabetes complications; Metabolic syndrome; Type 1 diabetes
ID METABOLIC SYNDROME; GLYCEMIC CONTROL; RETINOPATHY; ADULTS; DISEASE;
   HEALTH; CARE
AB Aims: To investigate the association between depressive symptomatology and health markers in type 1 diabetes.
   Methods: Four countries from the InterDiane Consortium had adopted the Finnish Diabetic Nephropathy Study protocol, including the Beck Depression Inventory (BDI). Associations between depression symptomatology, diabetes complications (diabetic nephropathy, proliferative retinopathy, major adverse cardiovascular events [MACE]) and vascular risk factors (metabolic syndrome, body mass index, glycaemic control) were investigated.
   Results: In a sample of 1046 participants (Croatia n = 99; Finland n = 314; Latvia n = 315; Lithuania n = 318), 13.4% displayed symptoms of depression (BDI score 16) with no statistically significant difference in the prevalence of depression among the cohorts. The highest rates of diabetic nephropathy (37.1%) and proliferative retinopathy (36.3%) were observed in Lithuania. The rates of MACE and metabolic syndrome were highest in Finland. In joint analyses, individuals exhibiting depression symptomatology had higher HbA(1c) (79 vs. 72 mmol/mol, p < 0.001) and higher triglyceride concentration (1.67 vs. 1.28 mmol/l, p < 0.001), than those without. In the multivariable model, BDI score was positively associated with the presence of diabetic nephropathy, proliferative retinopathy, MACE, and metabolic syndrome and its triglyceride component. Moreover, BDI score was positively associated with the number of metabolic syndrome components, triglyceride concentration, and HbA(1c).
   Conclusions: Comorbid depression should be considered a relevant factor explaining metabolic problems and vascular outcomes. Causality cannot be inferred from this crosssectional study. (c) 2020 Elsevier B.V. All rights reserved.
C1 [Ahola, Aila J.; Forsblom, Carol] Folkhalsan Res Ctr, Folkhalsan Inst Genet, Helsinki, Finland.
   [Ahola, Aila J.; Forsblom, Carol] Univ Helsinki, Abdominal Ctr, Nephrol, Helsinki, Finland.
   [Ahola, Aila J.; Forsblom, Carol] Univ Helsinki, Cent Hosp, Helsinki, Finland.
   [Ahola, Aila J.; Forsblom, Carol] Univ Helsinki, Res Program Clin & Mol Metab, Fac Med, Helsinki, Finland.
   [Radzeviciene, Lina; Verkauskiene, Rasa] Lithuanian Univ Hlth Sci, Med Acad, Inst Endocrinol, Kaunas, Lithuania.
   [Zaharenko, Linda; Rovite, Vita; Pirags, Valdis] Latvian Biomed Res & Study Ctr, Rtsupites St 1, LV-1067 Riga, Latvia.
   [Bulum, Tomislav; Roso, Vinko; Duvnjak, Lea] Univ Zagreb, Sch Med, Vuk Vrhovac Clin Diabet Endocrinol & Metab Dis, Merkur Univ Hosp, Zagreb, Croatia.
   [Skrebinska, Sabine; Pirags, Valdis; Sokolovska, Jelizaveta] Univ Latvia, Fac Med, Jelgavas St 3, LV-1004 Riga, Latvia.
   [Prakapiene, Edita] Lithuanian Univ Hlth Sci, Med Acad, Dept Endocrinol, Kaunas, Lithuania.
   [Blaslov, Kristina] Univ Clin Hosp Ctr, Dept Endocrinol Diabet & Metab Dis, Zagreb, Croatia.
   [Pirags, Valdis] Pauls Stradins Clin Univ Hosp, Pilsonu St 13, LV-1002 Riga, Latvia.
C3 Folkhalsan Research Center; University of Helsinki; University of
   Helsinki; Helsinki University Central Hospital; University of Helsinki;
   Lithuanian University of Health Sciences; Latvian Biomedical Research &
   Study Centre; University of Zagreb; University of Latvia; Lithuanian
   University of Health Sciences; Pauls Stradins Clinical University
   Hospital
RP Forsblom, C (corresponding author), Univ Helsinki, Res Program Clin & Mol Metab, Fac Med, Helsinki, Finland.; Forsblom, C (corresponding author), Univ Helsinki, Folkhalsan Res Ctr, Biomedicum Helsinki C430b,POB 63, FI-00014 Helsinki, Finland.
EM carol.forsblom@hus.fi
RI sokolovska, Jelizaveta/ADQ-1946-2022
OI Ahola, Aila/0000-0001-5200-4597; Sokolovska,
   Jelizaveta/0000-0003-0448-8229
FU Academy of Finland [316664]; Novo Nordisk Foundation [OC0013659]; Signe
   and Ane Gyllenberg Foundation; Folkhalsan Research Foundation; Helsinki
   University Central Hospital Research Funds; Wilhelm and Else Stockmann
   Foundation; Liv och Halsa Society; Paivikki and Sakari Sohlberg
   Foundation; State Genome database project, Latvian Association of
   Endocrinology, a project of the University of Latvia; European Regional
   Development Fund [1.1.1.2/VIAA/2/18/287]; Science fund of Lithuanian
   University of Health Sciences
FX Finland Study was supported by Academy of Finland (#316664); Novo
   Nordisk Foundation (#OC0013659); Signe and Ane Gyllenberg Foundation;
   Folkhalsan Research Foundation; Helsinki University Central Hospital
   Research Funds; Wilhelm and Else Stockmann Foundation; Liv och Halsa
   Society; and Paivikki and Sakari Sohlberg Foundation. The skilled
   technical assistance of Anna Sandelin, Mira Korolainen, and Jaana
   Tuomikangas is gratefully acknowledged. The authors acknowledge the
   physicians and nurses at each centre (Supplementary Table 2). LatviaWork
   was supported by State Genome database project, Latvian Association of
   Endocrinology, a project of the University of Latvia; and European
   Regional Development Fund (#1.1.1.2/VIAA/2/18/287). We thank Sanita
   KalvaVaivode and M~arite Cirse for their skilful coordination of
   patients' recruitment, and all physicians involved in the recruitment of
   patients. Lithuania Study was partly supported by the Science fund of
   Lithuanian University of Health Sciences. We acknowledge all the
   physicians and nurses participating in the recruitment and follow-up of
   patients, in particular Dzilda Velickiene, Vladimiras Petrenko and
   Jurate Lasiene. Funding agencies did not contribute to the study design,
   conduct of the study, analysis of samples or data, interpretation of the
   findings, writing of the manuscript, or in the decision to submit the
   manuscript for publication.
CR Ahola AJ, 2012, DIABETOLOGIA, V55, P73, DOI 10.1007/s00125-011-2347-6
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NR 36
TC 10
Z9 10
U1 0
U2 8
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0168-8227
EI 1872-8227
J9 DIABETES RES CLIN PR
JI Diabetes Res. Clin. Pract.
PD DEC
PY 2020
VL 170
AR 108495
DI 10.1016/j.diabres.2020.108495
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism
GA PK3HY
UT WOS:000602341800014
PM 33058955
DA 2025-06-11
ER

PT J
AU Martland, R
   Teasdale, S
   Murray, RM
   Gardner-Sood, P
   Smith, S
   Ismail, K
   Atakan, Z
   Greenwood, K
   Stubbs, B
   Gaughran, F
AF Martland, Rebecca
   Teasdale, Scott
   Murray, Robin M.
   Gardner-Sood, Poonam
   Smith, Shubulade
   Ismail, Khalida
   Atakan, Zerrin
   Greenwood, Kathryn
   Stubbs, Brendon
   Gaughran, Fiona
TI Dietary intake, physical activity and sedentary behaviour patterns in a
   sample with established psychosis and associations with mental health
   symptomatology
SO PSYCHOLOGICAL MEDICINE
LA English
DT Article
DE Depression; diet; global functioning; negative symptoms; physical
   activity; psychosis
ID MAJOR DEPRESSIVE DISORDER; BIPOLAR DISORDER; BIDIRECTIONAL ASSOCIATION;
   CARDIOVASCULAR RISK; METABOLIC SYNDROME; PRIMARY-CARE; PEOPLE;
   SCHIZOPHRENIA; INTERVENTION; EXERCISE
AB Background People with psychosis experience cardiometabolic comorbidities, including metabolic syndrome, coronary heart disease and diabetes. These physical comorbidities have been linked to diet, inactivity and the effects of the illness itself, including disorganisation, impairments in global function and amotivation associated with negative symptoms of schizophrenia or co-morbid depression. Methods We aimed to describe the dietary intake, physical activity (PA) and sedentary behaviour patterns of a sample of patients with established psychosis participating in the Improving Physical Health and Reducing Substance Use in Severe Mental Illness (IMPaCT) randomised controlled trial, and to explore the relationship between these lifestyle factors and mental health symptomatology. Results A majority of participants had poor dietary quality, low in fruit and vegetables and high in discretionary foods. Only 29.3% completed > 150 min of moderate and/or vigorous activity per week and 72.2% spent > 6 h per day sitting. Cross-sectional associations between negative symptoms, global function, and PA and sedentary behaviour were observed. Additionally, those with more negative symptoms receiving IMPaCT therapy had fewer positive changes in PA from baseline to 12-month follow-up than those with fewer negative symptoms at baseline. Conclusion These results highlight the need for the development of multidisciplinary lifestyle and exercise interventions to target eating habits, PA and sedentary behaviour, and the need for further research on how to adapt lifestyle interventions to baseline mental status. Negative symptoms in particular may reduce patient's responses to lifestyle interventions.
C1 [Martland, Rebecca; Murray, Robin M.; Gardner-Sood, Poonam; Smith, Shubulade; Ismail, Khalida; Atakan, Zerrin; Stubbs, Brendon; Gaughran, Fiona] Kings Coll London, Inst Psychiat Psychol & Neurosci IoPPN, London, England.
   [Teasdale, Scott] Univ New South Wales Sydney, Sch Psychiat, High St, Kensington, NSW 2033, Australia.
   [Murray, Robin M.; Smith, Shubulade; Stubbs, Brendon; Gaughran, Fiona] South London & Maudsley NHS Fdn Trust, Denmark Hill, London SE5 8AZ, England.
   [Greenwood, Kathryn] Univ Sussex, Sussex Partnership NHS Fdn Trust, Brighton, E Sussex, England.
   [Greenwood, Kathryn] Univ Sussex, Sch Psychol, Brighton, E Sussex, England.
C3 University of London; King's College London; University of New South
   Wales Sydney; University of Sussex; University of Sussex
RP Martland, R (corresponding author), Kings Coll London, Inst Psychiat Psychol & Neurosci IoPPN, London, England.
EM rrbecca.martland@kcl.ac.uk
RI Teasdale, Scott/AFP-0676-2022; greenwood, kathryn/I-8638-2012; Gaughran,
   Fiona/AAC-7160-2019; Stubbs, Brendon/X-1904-2018; murray,
   robin/F-8658-2012; Gaughran, Fiona/H-5495-2011; Stubbs,
   Brendon/C-5696-2015
OI Martland, Rebecca Nicole/0000-0002-4080-0171; Greenwood,
   Kathryn/0000-0001-7899-8980; murray, robin/0000-0003-0829-0519;
   Gaughran, Fiona/0000-0001-7414-5569; Teasdale,
   Scott/0000-0001-6769-8421; Stubbs, Brendon/0000-0001-7387-3791; Smith,
   Shubulade/0000-0002-3797-6985
FU NIHR Biomedical Research Centre at South London and Maudsley NHS
   Foundation Trust and King's College London; Health Education England
   (HEE) [ICA-CL-2017-03-001]; National Institute for Health Research
   (NIHR) [ICA-CL-2017-03-001]; National Institute for Health Research's
   (NIHR) Biomedical Research Centre at South London and Maudsley NHS
   Foundation Trust and King's College London; Maudsley Charity; National
   Institute for Health Research (NIHR) Applied Research Collaboration
   South London (NIHR ARC South London) at King's College Hospital NHS
   Foundation Trust
FX RM is supported by a Ph.D. studentship from the NIHR Biomedical Research
   Centre at South London and Maudsley NHS Foundation Trust and King's
   College London. BS is supported by a Clinical Lectureship
   (ICA-CL-2017-03-001) jointly funded by Health Education England (HEE)
   and the National Institute for Health Research (NIHR). FG is supported
   by the National Institute for Health Research's (NIHR) Biomedical
   Research Centre at South London and Maudsley NHS Foundation Trust and
   King's College London and by the Maudsley Charity and the National
   Institute for Health Research (NIHR) Applied Research Collaboration
   South London (NIHR ARC South London) at King's College Hospital NHS
   Foundation Trust. The views expressed are those of the authors and not
   necessarily those of the NIHR or the Department of Health and Social
   Care.
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NR 65
TC 23
Z9 23
U1 3
U2 21
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0033-2917
EI 1469-8978
J9 PSYCHOL MED
JI Psychol. Med.
PD MAR
PY 2023
VL 53
IS 4
BP 1565
EP 1575
AR PII S0033291721003147
DI 10.1017/S0033291721003147
EA AUG 2021
PG 11
WC Psychology, Clinical; Psychiatry; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA D7MY1
UT WOS:000786717400001
PM 34420532
OA Green Published, hybrid, Green Accepted
DA 2025-06-11
ER

PT J
AU Happell, B
   Galletly, C
   Castle, D
   Platania-Phung, C
   Stanton, R
   Scott, D
   McKenna, B
   Millar, F
   Liu, D
   Browne, M
   Furness, T
AF Happell, Brenda
   Galletly, Cherrie
   Castle, David
   Chris Platania-Phung
   Stanton, Robert
   Scott, David
   McKenna, Brian
   Millar, Freyja
   Liu, Dennis
   Browne, Matthew
   Furness, Trentham
TI Scoping review of research in Australia on the co-occurrence of physical
   and serious mental illness and integrated care
SO INTERNATIONAL JOURNAL OF MENTAL HEALTH NURSING
LA English
DT Review
DE comorbidity; mental health nursing; physical illness; psychosis; review;
   schizophrenia
ID RANDOMIZED CONTROLLED-TRIAL; INDUCED WEIGHT-GAIN; SMOKING-CESSATION
   INTERVENTION; PSYCHIATRIC INPATIENT SETTINGS; CARDIOMETABOLIC
   RISK-FACTORS; LIFE-STYLE INTERVENTION; QUALITY-OF-CARE; HEALTH-CARE;
   METABOLIC SYNDROME; CIGARETTE-SMOKING
AB The physical health of people with serious mental illness (SMI) has become a focal area of research. The aim of the present study was to ascertain the attention and distribution of research from within Australia on physical illness and SMI co-occurrence, and to identify gaps. A scoping review of peer-reviewed research literature from Australia, published between January 2000 and March 2014, was undertaken through an electronic literature search and coding of papers to chart trends. Four trends are highlighted: (i) an almost threefold increase in publications per year from 2000-2006 to 2007-2013; (ii) a steady release of literature reviews, especially from 2010; (iii) health-related behaviours, smoking, integrated-care programmes, and antipsychotic side-effects as the most common topics presented; and (iv) paucity of randomized, controlled trials on integrated-care models. Despite a marked increase in research attention to poorer physical health, there remains a large gap between research and the scale of the problem previously identified. More papers were descriptive or reviews, rather than evaluations of interventions. To foster more research, 12 research gaps are outlined. Addressing these gaps will facilitate the reduction of inequalities in physical health for people with SMI. Mental health nurses are well placed to lead multidisciplinary, consumer-informed research in this area.
C1 [Happell, Brenda; Chris Platania-Phung] Univ Canberra, Synergy, Nursing & Midwifery Res Ctr, Canberra, ACT 2601, Australia.
   [Happell, Brenda; Chris Platania-Phung] Canberra Hosp, ACT Hlth, Canberra, ACT, Australia.
   [Galletly, Cherrie] Univ Adelaide, Adelaide Clin, Adelaide, SA, Australia.
   [Galletly, Cherrie] Univ Adelaide, Sch Med, Adelaide, SA, Australia.
   [Liu, Dennis] Northern Mental Hlth Serv, Salisbury, SA, Australia.
   [Castle, David] Univ Melbourne, St Vincents Hosp, Melbourne, Vic, Australia.
   [Castle, David] Univ Melbourne, Sch Med, Melbourne, Vic, Australia.
   [Scott, David] Cent Queensland Univ, Sch Med & Appl Sci, Melbourne, Vic, Australia.
   [McKenna, Brian; Furness, Trentham] Australian Catholic Univ, Sch Nursing Midwifery & Paramed, Melbourne, Vic, Australia.
   [McKenna, Brian; Furness, Trentham] NorthWestern Mental Hlth, Melbourne, Vic, Australia.
   [Millar, Freyja] Eastern Hlth, Melbourne, Vic, Australia.
   [Stanton, Robert; Browne, Matthew] Cent Queensland Univ, Sch Human Hlth & Social Sci, Bundaberg, Qld, Australia.
C3 University of Canberra; Australian National University; Canberra
   Hospital; ACT Health Australia; University of Adelaide; University of
   Adelaide; St Vincent's Health; St Vincent's Hospital Melbourne;
   University of Melbourne; NSW Health; St Vincents Hospital Sydney;
   University of Melbourne; Central Queensland University; Australian
   Catholic University; Eastern Health; Central Queensland University
RP Happell, B (corresponding author), Canberra Hosp, Synergy, Nursing & Midwifery Res Ctr, Level 3 Bldg 6,Yaamba Rd, Woden, ACT 2606, Australia.
EM Brenda.Happell@canberra.edu.au
RI Stanton, Rob/AAJ-5157-2020; Scott, David/AAE-5031-2021; Furness,
   Trentham/N-8563-2016; Happell, Brenda/HSI-0570-2023
OI Castle, David/0000-0002-3075-1580; Scott, David/0000-0001-5226-1972;
   Browne, Matthew/0000-0002-2668-6229; Furness,
   Trentham/0000-0002-3526-1687; Happell, Brenda/0000-0002-7293-6583
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NR 208
TC 16
Z9 16
U1 1
U2 37
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1445-8330
EI 1447-0349
J9 INT J MENT HEALTH NU
JI Int. J. Ment. Health Nurs.
PD OCT
PY 2015
VL 24
IS 5
BP 421
EP 438
DI 10.1111/inm.12142
PG 18
WC Nursing; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Psychiatry
GA CQ6QN
UT WOS:000360729100006
PM 26220151
DA 2025-06-11
ER

PT J
AU Rusowicz, J
   Serweta, A
   Juszko, K
   Idzikowski, W
   Gajda, R
   Szczepanska-Gieracha, J
AF Rusowicz, Jagoda
   Serweta, Anna
   Juszko, Karolina
   Idzikowski, Wojciech
   Gajda, Robert
   Szczepanska-Gieracha, Joanna
TI Factors Associated with Undertaking Health-Promoting Activities by Older
   Women at High Risk of Metabolic Syndrome
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Article
DE physical activity; metabolic syndrome; health-promoting education;
   depressive symptoms; obesity; public health
ID PHYSICAL-ACTIVITY; LIFE-STYLE; DEPRESSION; ADULTS; MANAGEMENT; BARRIERS;
   POPULATION; EXERCISE; OBESITY; RECOMMENDATIONS
AB Background: The complexity of health problems concerning women aged >= 60 years makes it necessary to develop effective, low-cost strategies involving biopsychosocial interventions. The aim of this study is to identify the factors associated with undertaking health-promoting activities by older women at high risk of metabolic syndrome (MetS) with or without depressive symptoms. Methods: The study group consisted of 70 older women (62-84 years old) undertaking regular physical activity. A self-developed questionnaire (used to determine the living situation, selected lifestyle components and health problems), the Perceived Stress Questionnaire (PSQ) and the Geriatric Depression Scale (GDS) were used. Results: In the study group undertaking regular physical activity, 40% had increased symptoms of depression (D group), and 60% were classified as non-depressed (ND group). The D group had a higher general stress level (t = -6.18, p = 0.001). Improving and/or maintaining physical fitness was identified as the greatest motivation in both groups. Willingness to spend time with other people significantly differed between the two groups (chi(2) = 4.148, p = 0.042). The sole factor significantly differentiating between both groups was lack of time (chi(2) = 8.777, p = 0.003). Conclusions: Motivations and barriers to undertaking health-promoting activities and levels of perceived stress were significantly different between the depressed and non-depressed groups. It is important to encourage primary care physicians to perform screening tests for late-life depression and to provide information on where therapeutic interventions are available for patients with symptoms of MetS and coexisting depressive symptoms.
C1 [Rusowicz, Jagoda; Serweta, Anna; Juszko, Karolina; Szczepanska-Gieracha, Joanna] Wroclaw Univ Hlth & Sport Sci, Dept Physiotherapy, PL-51612 Wroclaw, Poland.
   [Idzikowski, Wojciech] Wroclaw Univ Hlth & Sport Sci, Dept Phys Educ & Sport Sci, PL-51612 Wroclaw, Poland.
   [Gajda, Robert] Gajda Med Dist Hosp, PL-06100 Pultusk, Poland.
   [Gajda, Robert] Jan Dlugosz Univ, Dept Kinesiol & Hlth Prevent, PL-42200 Czestochowa, Poland.
C3 Jan Dlugosz University
RP Rusowicz, J (corresponding author), Wroclaw Univ Hlth & Sport Sci, Dept Physiotherapy, PL-51612 Wroclaw, Poland.
EM jagodarusowicz@gmail.com
RI Idzikowski, Wojciech/JCO-3422-2023; Rusowicz, Jagoda/ABA-9562-2020;
   Gajda, Robert/AAL-3361-2020
OI Serweta-Pawlik, Anna/0000-0002-7699-6890; Szczepanska-Gieracha,
   Joanna/0000-0001-5191-3799; Gajda, Robert/0000-0002-8305-8130; Juszko,
   Karolina/0000-0003-1968-2796; Rusowicz, Jagoda/0000-0001-5635-9555
FU Foundation for Senior Citizen Activation SIWY DYM in Wroclaw;
   Municipality of Wroclaw
FX The study was carried out at the Foundation for Senior Citizen
   Activation SIWY DYM in Wroclaw within a Mental Health Promotion
   Programme. A part of the project involving therapeutic activities
   received funding from the Municipality of Wroclaw.
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NR 92
TC 0
Z9 0
U1 0
U2 6
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD DEC
PY 2022
VL 19
IS 23
AR 15957
DI 10.3390/ijerph192315957
PG 16
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA 6Y7FP
UT WOS:000897256900001
PM 36498030
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Azadbakht, L
   Mirmiran, P
   Esmaillzadeh, A
   Azizi, T
   Azizi, F
AF Azadbakht, L
   Mirmiran, P
   Esmaillzadeh, A
   Azizi, T
   Azizi, F
TI Beneficial effects of a Dietary Approaches to Stop Hypertension eating
   plan on features of the metabolic syndrome
SO DIABETES CARE
LA English
DT Article
ID INSULIN-RESISTANCE SYNDROME; BLOOD-PRESSURE; LOW-FAT; DAIRY CONSUMPTION;
   OXIDATIVE STRESS; BODY-COMPOSITION; DASH DIET; PREVALENCE; ADULTS;
   OBESITY
AB OBJECTIVE - To determine the effects of a Dietary Approaches to Stop Hypertension (DASH) eating plan on metabolic risks in patients with the metabolic syndrome.
   RESEARCH DESIGN AND METHODS - This was a randomized controlled ompatient trial conducted on 116 patients with the metabolic syndrome. Three diets were prescribed for 6 months: a control diet, a weight-reducing diet emphasizing healthy food choices, and the DASH diet with reduced calories and increased consumption of fruit, vegetables, low-fat dairy, and whole grains and lower in saturated fat, total fat, and cholesterol and restricted to 2,400 mg Na. The main outcome measures were the components of the metabolic syndrome.
   RESULTS - Relative to the control diet, the DASH diet resulted in higher HDL cholesterol (7 and 10 mg/dl), lower triglycerides (- 18 and - 14 mg/dl), systolic blood pressure (SBP) (- 12 and -11 mmHg), diastolic blood pressure (- 6 and - 7 mmHg), weight (- 16 and - 14 kg), fasting blood glucose (FBG) (- 15 and -8 mg/dl), and weight (- 16 and - 15 kg), among men and women, respectively (all P < 0.001). The net reduction in triglycerides (- 17 and - 18 mg/dl), SBP (-11 and -11 mmHg), diastolic blood pressure (- 5 and - 6 mmHg), and FBG (- 4 and - 6 mg/dl), weight (- 16 and - 15 kg), and increase in HDL (5 and 10 mg/dl) among men and women, respectively, was higher in the DASH group (all P < 0.05). The weight-reducing diet resulted in significant change in triglycerides (-13 and -10 mg/dl), SBP (- 6 and - 6 mmHg), and weight (- 13 and - 12 kg) among men and women, respectively (all P < 0.05).
   CONCLUSIONS - The DASH diet can likely reduce most of the metabolic risks in both men and women; the related mechanisms need further study.
C1 Shahid Beheshti Univ Med Sci, Endocrine Res Ctr, Tehran, Iran.
C3 Shahid Beheshti University Medical Sciences
RP Shahid Beheshti Univ Med Sci, Endocrine Res Ctr, POB 19395-4763, Tehran, Iran.
EM azizi@erc.ac.ir
RI Mirmiran, Parvin/V-1433-2019; Esmaillzadeh, Ahmad/N-5704-2014; Azizi,
   Fereidoun/ABD-4136-2021; Azadbakht, Leila/N-2801-2018
OI Esmaillzadeh, Ahmad/0000-0002-8735-6047; Mirmiran,
   Parvin/0000-0003-2391-4924; Azizi, Fereidoun/0000-0002-6470-2517;
   Azadbakht, Leila/0000-0002-5955-6818
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NR 48
TC 388
Z9 444
U1 0
U2 33
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0149-5992
EI 1935-5548
J9 DIABETES CARE
JI Diabetes Care
PD DEC
PY 2005
VL 28
IS 12
BP 2823
EP 2831
DI 10.2337/diacare.28.12.2823
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 988HJ
UT WOS:000233583500002
PM 16306540
DA 2025-06-11
ER

PT J
AU Atlantis, E
   Lange, K
   Goldney, RD
   Martin, S
   Haren, MT
   Taylor, A
   O'Loughlin, PD
   Marshall, V
   Tilley, W
   Wittert, GA
AF Atlantis, Evan
   Lange, Kylie
   Goldney, Robert D.
   Martin, Sean
   Haren, Matthew T.
   Taylor, Anne
   O'Loughlin, Peter D.
   Marshall, Villis
   Tilley, Wayne
   Wittert, Gary A.
TI Specific medical conditions associated with clinically significant
   depressive symptoms in men
SO SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY
LA English
DT Article
DE Depression; Cardiovascular disease; Muscle strength; Triglycerides; LUTS
ID NATIONAL COMORBIDITY SURVEY; SYMPATHETIC ACTIVITY; METABOLIC SYNDROME;
   BLOOD-PRESSURE; ANXIETY; DISORDER; HEALTH; RISK; INDIVIDUALS; PREVALENCE
AB To define specific medical conditions associated with clinically significant depressive symptoms in men.
   A cross-sectional study was conducted in a community-based sample of Australian men (N = 1,195, aged 35-80 years; for 2002-2005). Depression was defined by: (1) symptomatic depression (current symptoms) or (2) current prescription for antidepressant(s) or (3) previously diagnosed depression. Logistic regression was used to determine prevalence odds ratios (OR) for depression independently associated with an extensive range of demographic, lifestyle, and clinical factors. Adjusted population attributable risk (PAR%) estimates were also computed.
   Depression was significantly (ORs at P < 0.05) associated with previously diagnosed anxiety (12.0) and insomnia (4.4), not married (1.7), current smoker (1.7), low muscle strength tertile (1.7, P = 0.059), high triglycerides (1.6), high storage lower urinary tract symptoms (LUTS) tertile (1.8), past year general practitioner visits 5-9 (1.9), middle energy density tertile (0.4), and high systolic blood pressure (0.5). Significant PAR% estimates (at P < 0.05) were for previous anxiety (27.0%) and insomnia (16.1%), middle energy density tertile (-17.2%), high SBP (-23.5%), high triglycerides (15.2%), and high storage LUTS tertile (12.6%). Results strengthened when depression-related factors (previous anxiety and insomnia, psycholeptics, and cognition) were omitted, and became significant for CVD (OR 1.6; PAR 13.9%).
   Medical conditions associated with depression in men include high triglycerides, low muscle strength, CVD, and LUTS. Depressed men are likely to use health services frequently, be current smokers, not be married, eat unhealthily, and report previous diagnosis of anxiety and insomnia; which has important implications for clinicians managing male patients.
C1 [Atlantis, Evan; O'Loughlin, Peter D.; Tilley, Wayne; Wittert, Gary A.] Royal Adelaide Hosp, Inst Med & Vet Sci, Adelaide, SA 5000, Australia.
   [Atlantis, Evan; Martin, Sean; O'Loughlin, Peter D.; Marshall, Villis; Tilley, Wayne; Wittert, Gary A.] Univ Adelaide, Sch Med, Freemasons Fdn Ctr Mens Hlth, Adelaide, SA 5005, Australia.
   [Lange, Kylie; Wittert, Gary A.] Univ Adelaide, Ctr Clin Res Excellence Nutr Physiol Intervent &, Sch Med, Adelaide, SA 5005, Australia.
   [Goldney, Robert D.] Univ Adelaide, Discipline Psychiat, Adelaide, SA 5005, Australia.
   [Goldney, Robert D.] Royal Adelaide Hosp, SA Pathol, Hanson Inst, Adelaide, SA 5000, Australia.
   [Haren, Matthew T.; Taylor, Anne] Univ S Australia, SANSOM Inst, Div Hlth Sci, Adelaide, SA 5001, Australia.
   [Tilley, Wayne] Univ Adelaide, Sch Med, Dame Roma Mitchell Canc Res Labs, Adelaide, SA 5005, Australia.
   [Tilley, Wayne] Univ Adelaide, Discipline Med, Adelaide, SA 5005, Australia.
C3 Institute Medical & Veterinary Science Australia; Royal Adelaide
   Hospital; University of Adelaide; University of Adelaide; University of
   Adelaide; SA Pathology; Royal Adelaide Hospital; Hanson Institute;
   University of South Australia; University of Adelaide; University of
   Adelaide
RP Atlantis, E (corresponding author), Royal Adelaide Hosp, Inst Med & Vet Sci, Adelaide, SA 5000, Australia.
EM evan.atlantis@adelaide.edu.au
RI Lange, Kylie/D-8082-2013; wittert, gary/AAE-2398-2019; Atlantis,
   Evan/ABC-8075-2021; Haren, Matthew/A-3191-2008; Taylor, Anne/F-5708-2010
OI Haren, Matthew/0000-0003-2464-4364; Taylor, Anne/0000-0002-4422-7974;
   Atlantis, Evan/0000-0001-5877-6141; Tilley, Wayne/0000-0003-1893-2626;
   O'Loughlin, Peter/0009-0002-0500-4433
FU The University of Adelaide's Florey Foundation; South Australian
   Government; National Health and Medical Research Council of Australia
   (NHMRC) [453662, 511345]
FX The authors would like to acknowledge the clinic and recruitment staff
   for their invaluable efforts. Particular thanks are extended to Janet
   Grant, Sandy Pickering and to staff of the North West Adelaide Health
   Study for all their assistance. Thanks to Chris Seaborn and Erika Bowden
   and staff at the Department of Nuclear Medicine, The Queen Elizabeth
   Hospital for providing expertise and assistance with DXA procedures.
   Finally, thanks are extended to our participants and their families for
   their invaluable contributions. The study was initially supported by The
   University of Adelaide's Florey Foundation and is currently partially
   funded by the South Australian Government's Men's Health Program. This
   work was also funded by the National Health and Medical Research Council
   of Australia (NHMRC project grant # 453662, WDT; Training Fellowship
   Public Health grant # 511345, MTH).
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NR 57
TC 22
Z9 23
U1 0
U2 7
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0933-7954
EI 1433-9285
J9 SOC PSYCH PSYCH EPID
JI Soc. Psychiatry Psychiatr. Epidemiol.
PD DEC
PY 2011
VL 46
IS 12
BP 1303
EP 1312
DI 10.1007/s00127-010-0302-3
PG 10
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 849VT
UT WOS:000297154100012
PM 20976591
DA 2025-06-11
ER

PT J
AU Suttajit, S
   Pilakanta, S
AF Suttajit, Sirijit
   Pilakanta, Sutrak
TI Prevalence of metabolic syndrome and its association with depression in
   patients with schizophrenia
SO NEUROPSYCHIATRIC DISEASE AND TREATMENT
LA English
DT Article
DE mood symptoms; hypertension; dyslipidemia; hyperglycemia; central
   obesity
ID CLINICAL ANTIPSYCHOTIC TRIALS; CARDIOVASCULAR MORTALITY; ALL-CAUSE;
   SYMPTOMS; RISK
AB Purpose: To identify the point prevalence of metabolic syndrome in patients with schizophrenia and to evaluate the association between depressive symptoms and metabolic syndrome in patients with schizophrenia.
   Patients and methods: Metabolic syndrome was assessed based on an updated definition derived from the modified National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATP III) and the International Diabetes Federation criteria. The 17-item Hamilton Depression Rating Scale (HDRS-17) was used to measure depressive symptoms in 80 patients with schizophrenia. Odds ratios and 95% confidence intervals were calculated using logistic regression for the association between each depressive symptom and metabolic syndrome.
   Results: The point prevalence rates of metabolic syndrome according to the modified NCEP-ATP III and International Diabetes Federation criteria were 37% and 35%, respectively. The risk of having metabolic syndrome significantly increased in those who were widowed or separated, or had longer duration of illness. Central obesity was the metabolic feature with the highest odds ratios for metabolic syndrome at 19.3. Three out of 17 items of HDRS subscales were found to be significantly associated with metabolic syndrome, including depressed mood, middle insomnia, and retardation with the odds ratios of 3.0, 3.4, and 3.6, respectively.
   Conclusion: This study showed that the prevalence of metabolic syndrome in patients with schizophrenia was higher than the overall rate but was slightly lower than in the general population in the USA. Central obesity, measured by waist circumference, was found to be highly correlated with metabolic syndrome. Depressed mood, middle insomnia, and retardation were significantly associated with metabolic syndrome in patients with schizophrenia. Waist circumference and screening for depression should be done at the clinics during patient follow-up.
C1 [Suttajit, Sirijit; Pilakanta, Sutrak] Chiang Mai Univ, Dept Psychiat, Fac Med, Chiang Mai 50200, Thailand.
C3 Chiang Mai University
RP Suttajit, S (corresponding author), Chiang Mai Univ, Dept Psychiat, Fac Med, Chiang Mai 50200, Thailand.
EM sirijits@gmail.com
OI Suttajit, Sirijit/0000-0002-6408-769X
FU Faculty of Medicine, Chiang Mai University
FX This study was supported by a grant from the Faculty of Medicine, Chiang
   Mai University.
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NR 36
TC 25
Z9 27
U1 0
U2 6
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
EI 1178-2021
J9 NEUROPSYCH DIS TREAT
JI Neuropsychiatr. Dis. Treat.
PY 2013
VL 9
BP 941
EP 946
DI 10.2147/NDT.S47450
PG 6
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Psychiatry
GA 178ZI
UT WOS:000321485500001
PM 23882141
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Kajantie, E
   Eriksson, J
   Osmond, C
   Wood, PJ
   Forsén, T
   Barker, DJP
   Phillips, DIW
AF Kajantie, E
   Eriksson, J
   Osmond, C
   Wood, PJ
   Forsén, T
   Barker, DJP
   Phillips, DIW
TI Size at birth, the metabolic syndrome and 24-h salivary cortisol profile
SO CLINICAL ENDOCRINOLOGY
LA English
DT Article
ID INSULIN-RESISTANCE SYNDROME; GESTATIONAL-AGE; BLOOD-PRESSURE; ADULT
   LIFE; WEIGHT; STRESS; SECRETION; AXIS; MEN; HYPOCORTISOLISM
AB OBJECTIVE Individual variation in hypothalamic-pituitary-adrenal axis (HPAA) function has been suggested to be important in linking small size at birth with adult cardiovascular disease and its risk factors, in particular the metabolic syndrome. Human studies have, however, so far only been performed in clinic settings, and their results have not been consistent. Our aim was to assess whether HPAA activity in everyday living circumstances is related to the metabolic syndrome and size at birth.
   DESIGN Clinical birth cohort study.
   SUBJECTS A total of 151 women born between 1924 and 1933 in Helsinki, Finland, with measurements at birth recorded. The subjects had previously undergone detailed clinical examinations including fasting cortisol measurement and 1 mug ACTH(1-24) and overnight 0.25 mg dexamethasone tests.
   MEASUREMENTS Salivary cortisol concentration was measured during a normal 24-h period: at awakening, 15 and 30 min thereafter, at 12.00 h, 17.00 h and 22.00 h and the following morning. In addition, the following summary variables were calculated: awakening response (mean of the three awakening measurements), mean of all individual measurements, and mean, SD and contrast (a measure of blunted diurnal variability, calculated as mean of morning minus mean of 1200, 1700 and 2200) of all individual z scores.
   RESULTS Salivary cortisol awakening response was correlated with serum fasting (r = 0.17; P = 0.04), ACTH(1-24)-stimulated (r = 0.32; P < 0.0001), and dexamethasone-suppressed (r = 0.29; P = 0.0004) cortisol concentrations. However, no salivary cortisol measurement was associated with any component of the metabolic syndrome (waist circumference, serum triglyceride, HDL cholesterol or glucose concentration, or blood pressure). Moreover, no correlation was observed between salivary cortisol and weight, length, ponderal index, or gestational age at birth.
   CONCLUSIONS In elderly women, cortisol concentrations in an everyday environment do not appear to be associated with the metabolic syndrome or size at birth. We propose that detecting relationships between HPAA function, prenatal events and adult disease might require a test involving HPAA stimulation.
C1 Natl Publ Hlth Inst, SF-00300 Helsinki, Finland.
   Southampton Gen Hosp, Environm Epidemiol Unit, Southampton SO9 4XY, Hants, England.
   Univ Helsinki, Cent Hosp, Hosp Children & Adolescents, Helsinki, Finland.
   Southampton Gen Hosp, Endocrine Unit, Southampton SO9 4XY, Hants, England.
C3 Finland National Institute for Health & Welfare; University of
   Southampton; University of Helsinki; Helsinki University Central
   Hospital; University of Southampton
RP Kajantie, E (corresponding author), Natl Publ Hlth Inst, Mannerheimintie 166, SF-00300 Helsinki, Finland.
EM eero.kajantie@helsinki.fi
RI Gibbs, J. Raphael/A-3984-2010; Barker, David/A-5671-2013
OI Eriksson, Johan/0000-0002-2516-2060; Osmond, Clive/0000-0002-9054-4655
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NR 28
TC 50
Z9 54
U1 0
U2 4
PU BLACKWELL PUBLISHING LTD
PI OXFORD
PA 9600 GARSINGTON RD, OXFORD OX4 2DG, OXON, ENGLAND
SN 0300-0664
J9 CLIN ENDOCRINOL
JI Clin. Endocrinol.
PD FEB
PY 2004
VL 60
IS 2
BP 201
EP 207
DI 10.1046/j.1365-2265.2003.01965.x
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 764VB
UT WOS:000188225800008
PM 14725681
DA 2025-06-11
ER

PT J
AU Ruiz, LD
   Zuelch, ML
   Dimitratos, SM
   Scherr, RE
AF Ruiz, Lyndsey D.
   Zuelch, Michelle L.
   Dimitratos, Sarah M.
   Scherr, Rachel E.
TI Adolescent Obesity: Diet Quality, Psychosocial Health, and
   Cardiometabolic Risk Factors
SO NUTRIENTS
LA English
DT Review
DE adolescent; obesity; severe obesity; diet quality; psychosocial health;
   stress; cardiometabolic risk; food literacy
ID HIGH-SCHOOL-STUDENTS; BODY-MASS INDEX; TYPE-2 DIABETES-MELLITUS; ADULT
   METABOLIC SYNDROME; DEFINING FOOD LITERACY; INTIMA-MEDIA THICKNESS; LOW
   ADIPONECTIN LEVELS; CARDIOVASCULAR RISK; INSULIN-RESISTANCE; NUTRITION
   EDUCATION
AB Obesity is a multifaceted chronic condition with several contributing causes, including biological risk factors, socioeconomic status, health literacy, and numerous environmental influences. Of particular concern are the increasing rates of obesity in children and adolescents, as rates of obesity in youth in the United States have tripled within the last three decades. Youth from historically disadvantaged backgrounds tend to have higher rates of obesity compared to other groups. Adolescents often do not meet intake recommendations for certain food groups and nutrients, which may contribute to a heightened risk of obesity. With obesity disproportionately affecting adolescents (ages 12-19 years), negative effects of excess adiposity may be particularly salient during this critical period of development. The presentation of chronic cardiometabolic disease symptoms typically observed in adults, such as hypertension, hyperglycemia, dyslipidemia, and inflammation, are becoming increasingly common in adolescents with obesity. Additionally, there is dynamic interplay between obesity and psychosocial health, as adolescents with obesity may have increased levels of stress, depressive symptoms, and reduced resilience. To reduce and prevent adolescent obesity, the implementation of theory-driven multicomponent school- and community-based interventions have been suggested. These interventions promote knowledge and self-efficacy for healthful practices that have the potential to progress to sustained behavior change.
C1 [Ruiz, Lyndsey D.; Zuelch, Michelle L.; Dimitratos, Sarah M.; Scherr, Rachel E.] Univ Calif Davis, Dept Nutr, Davis, CA 95616 USA.
   [Ruiz, Lyndsey D.; Scherr, Rachel E.] Univ Calif Davis, Ctr Nutr Sch, Davis, CA 95616 USA.
   [Dimitratos, Sarah M.] USDA, Stress Biol & Human Nutr Res Lab, Obes & Metab Res Unit, Western Human Nutr Res Ctr, Davis, CA 95616 USA.
C3 University of California System; University of California Davis;
   University of California System; University of California Davis; United
   States Department of Agriculture (USDA)
RP Scherr, RE (corresponding author), Univ Calif Davis, Dept Nutr, Davis, CA 95616 USA.; Scherr, RE (corresponding author), Univ Calif Davis, Ctr Nutr Sch, Davis, CA 95616 USA.
EM ldruiz@ucdavis.edu; mzuelch@ucdavis.edu; smdimitratos@ucdavis.edu;
   rescherr@ucdavis.edu
RI Scherr, Rachel/Q-2922-2019
OI Dimitratos, Sarah/0000-0002-2416-1293; Scherr,
   Rachel/0000-0002-9962-5726; Zuelch, Michelle/0000-0001-9248-4900
FU USDA NIFA, National Needs Fellowship [2018-38420-27959]
FX L.D.R.: M.L.Z., and S.M.D. receive funding through USDA NIFA, National
   Needs Fellowship #2018-38420-27959.
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NR 206
TC 156
Z9 180
U1 9
U2 241
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JAN
PY 2020
VL 12
IS 1
AR 43
DI 10.3390/nu12010043
PG 22
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nutrition & Dietetics
GA KQ3KN
UT WOS:000516825500043
PM 31877943
OA Green Published, gold
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Sebeková, K
   Gurecká, R
   Csongová, M
   Koborová, I
   Sebek, J
AF Sebekova, Katarina
   Gurecka, Radana
   Csongova, Melinda
   Koborova, Ivana
   Sebek, Jozef
TI Elevated blood pressure-associated cardiometabolic risk factors and
   biomarkers in 16-23 years old students with or without metabolic
   abnormalities
SO JOURNAL OF HUMAN HYPERTENSION
LA English
DT Article
ID URIC-ACID; OXIDATIVE STRESS; HYPERTENSION; CHILDREN; OVERWEIGHT; PLASMA;
   SCORE; ADIPONECTIN; ADOLESCENTS; PREVALENCE
AB In obesity, cardiometabolic risk markers show worsening trends with increasing blood pressure (BP). We assumed that risk markers show similar trends across BP categories (normotension, high normal BP, hypertension) in metabolic abnormalities-free subjects (without obesity, insulin resistance, atherogenic dyslipidemia, hyperuricemia, microinflammation) and those presenting them. Data from 2547 (48.1% males) subjects aged 16-23 years were analyzed. The prevalence of males increased across BP categories. Forty-seven percent of individuals with elevated BP were metabolic abnormalities-free. Among 1461 metabolic abnormalities-free subjects, 9% had high normal BP, and 4% hypertension; among 1086 individuals presenting metabolic abnormalities, the prevalence reached 13% and 6%, respectively, (p < 0.001). Both groups displayed similar BP values in corresponding BP categories and significant trends in markers of adiposity, insulin resistance, HDL-cholesterol, atherogenic index of plasma, uric acid, adiponectinemia, and antioxidant capacity of plasma across BP categories. In metabolic abnormalities-free individuals, also significant trends in soluble receptors for advanced glycation end products were revealed. Continuous metabolic syndrome score, a measure of cardiometabolic risk, increased across BP categories regardless of presence or absence of metabolic abnormalities. Multivariate regression models selected male gender, fat-free mass, and uric acid as significant independent predictors for determining BP. Our data emphasize that having a BP outside the normal range significantly worsens risk for cardiometabolic disease in young individuals even if the thresholds for any of the risk factors are not exceeded. Longitudinal studies are needed to assess whether in patients with elevated BP the prognosis of adverse outcomes differs between those presenting and not presenting metabolic abnormalities.
C1 [Sebekova, Katarina; Gurecka, Radana; Csongova, Melinda; Koborova, Ivana] Comenius Univ, Fac Med, Inst Mol BioMed, Sasinkova 4, Bratislava 81108, Slovakia.
   [Gurecka, Radana] Comenius Univ, Fac Med, Inst Med Phys Biophys Informat & Telemed, Sasinkova 2, Bratislava 81108, Slovakia.
   [Sebek, Jozef] Slovak Acad Sci, Inst Mat & Machine Mech, Dubravska Cesta 9, Bratislava 84513, Slovakia.
C3 Comenius University Bratislava; Comenius University Bratislava; Slovak
   Academy of Sciences; Institute of Materials & Machine Mechanics, SAS
RP Sebeková, K (corresponding author), Comenius Univ, Fac Med, Inst Mol BioMed, Sasinkova 4, Bratislava 81108, Slovakia.
EM kata.sebekova@gmail.com
RI Csongová, Melinda/AAJ-8811-2020; Gurecka, Radana/AAX-6744-2021;
   Sebekova, Katarina/H-4906-2016
OI Sebekova, Katarina/0000-0002-9641-9265
FU Scientific Grant Agency of the Ministry of Education, Science, Research
   and Sport of the Slovak Republic; Slovak Academy of Sciences (VEGA)
   [1/0637/13]; Slovak Research and Development Agency (APVV) [0447-12];
   Bratislava Self-Governing Region
FX This study was funded by the Scientific Grant Agency of the Ministry of
   Education, Science, Research and Sport of the Slovak Republic and the
   Slovak Academy of Sciences (VEGA), grant no. 1/0637/13; the Slovak
   Research and Development Agency (APVV), grant no. 0447-12; and
   Bratislava Self-Governing Region. The sponsors had no role in study
   design; in the collection, analysis and interpretation of data; in the
   writing of the report; and in the decision to submit the article for
   publication.
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NR 35
TC 3
Z9 3
U1 0
U2 7
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0950-9240
EI 1476-5527
J9 J HUM HYPERTENS
JI J. Hum. Hypertens.
PD JAN
PY 2021
VL 35
IS 1
BP 37
EP 48
DI 10.1038/s41371-020-0309-5
EA FEB 2020
PG 12
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA PT6PC
UT WOS:000511538200001
PM 32029913
DA 2025-06-11
ER

PT J
AU Womack, VY
   De Chavez, PJ
   Albrecht, SS
   Durant, N
   Loucks, EB
   Puterman, E
   Redmond, N
   Siddique, J
   Williams, DR
   Carnethon, MR
AF Womack, Veronica Y.
   De Chavez, Peter John
   Albrecht, Sandra S.
   Durant, Nefertiti
   Loucks, Eric B.
   Puterman, Eli
   Redmond, Nicole
   Siddique, Juned
   Williams, David R.
   Carnethon, Mercedes R.
TI A Longitudinal Relationship Between Depressive Symptoms and Development
   of Metabolic Syndrome: The Coronary Artery Risk Development in Young
   Adults Study
SO PSYCHOSOMATIC MEDICINE
LA English
DT Article
DE depressive symptoms; metabolic syndrome; race; longitudinal
ID NUTRITION EXAMINATION SURVEY; 3RD NATIONAL-HEALTH; TYPE-2
   DIABETES-MELLITUS; INSULIN-RESISTANCE; MAJOR DEPRESSION;
   SEX-DIFFERENCES; OLDER-ADULTS; ASSOCIATION; CARDIA; WOMEN
AB Objective Despite variability in the burden of elevated depressive symptoms by sex and race and differences in the incidence of metabolic syndrome, few prior studies describe the longitudinal association of depressive symptoms with metabolic syndrome in a diverse cohort. We tested whether baseline and time-varying depressive symptoms were associated with metabolic syndrome incidence in black and white men and women from the Coronary Artery Risk Development in Young Adults study.
   Methods Participants reported depressive symptoms using the Center for Epidemiologic Studies Depression Scale at four examinations between 1995 and 2010. At those same examinations, metabolic syndrome was determined. Cox proportional hazards models were used to examine the associations of depressive symptoms on the development of metabolic syndrome in 3208 participants without metabolic syndrome at baseline.
   Results For 15 years, the incidence rate of metabolic syndrome (per 10,000 person-years) varied by race and sex, with the highest rate in black women (279.2), followed by white men (241.9), black men (204.4), and white women (125.3). Depressive symptoms (per standard deviation higher) were associated with incident metabolic syndrome in white men (hazard ratio = 1.25, 95% confidence interval = 1.08-1.45) and white women (hazard ratio = 1.17, 95% confidence interval = 1.00-1.37) after adjustment for demographic characteristics and health behaviors. There was no significant association between depression and metabolic syndrome among black men or black women.
   Conclusions Higher depressive symptoms contribute modestly to the onset of metabolic syndrome among white adults.
C1 [Womack, Veronica Y.] Northwestern Univ, Feinberg Sch Med, Div Fac Affairs, Chicago, IL 60611 USA.
   [De Chavez, Peter John; Siddique, Juned; Carnethon, Mercedes R.] Northwestern Univ, Feinberg Sch Med, Dept Prevent Med, 680 N Lake Shore Dr,Suite 1400, Chicago, IL 60611 USA.
   [Albrecht, Sandra S.] Univ North Carolina Chapel Hill, Gillings Sch Publ Hlth, Dept Nutr, Chapel Hill, NC USA.
   [Durant, Nefertiti] Univ Alabama Birmingham, Sch Med, Dept Pediat, Birmingham, AL USA.
   [Loucks, Eric B.] Brown Univ, Sch Publ Hlth, Dept Epidemiol, Providence, RI 02912 USA.
   [Puterman, Eli] Univ Calif San Francisco, Sch Med, Dept Psychiat, San Francisco, CA USA.
   [Redmond, Nicole] NIH, Div Prevent Med, Bldg 10, Bethesda, MD 20892 USA.
   [Williams, David R.] Harvard Univ, Sch Publ Hlth, NHLBI, 665 Huntington Ave, Boston, MA 02115 USA.
   [Redmond, Nicole] Univ Alabama Birmingham, Birmingham, AL USA.
C3 Northwestern University; Feinberg School of Medicine; Northwestern
   University; Feinberg School of Medicine; University of North Carolina;
   University of North Carolina Chapel Hill; University of North Carolina
   School of Medicine; University of Alabama System; University of Alabama
   Birmingham; Brown University; University of California System;
   University of California San Francisco; National Institutes of Health
   (NIH) - USA; Harvard University; Harvard T.H. Chan School of Public
   Health; National Institutes of Health (NIH) - USA; NIH National Heart
   Lung & Blood Institute (NHLBI); University of Alabama System; University
   of Alabama Birmingham
RP Carnethon, MR (corresponding author), Northwestern Univ, Feinberg Sch Med, Dept Prevent Med, 680 N Lake Shore Dr,Suite 1400, Chicago, IL 60611 USA.
EM carnethon@northwestern.edu
RI Loucks, Eric/I-1272-2014; Williams, David/JEO-2461-2023; Redmond,
   Nicole/I-8668-2019; Puterman, Eli/AAA-5237-2022
OI Carnethon, Mercedes/0000-0001-7035-0848; Redmond,
   Nicole/0000-0001-7298-5804; Puterman, Eli/0000-0002-5898-2348
FU National Heart, Lung, and Blood Institute [T32-HL-069771-07,
   HHSN268201300025C, HHSN268201300026C, HHSN268201300027C,
   HHSN268201300028C, HHSN268201300029C, HHSN268200900041C]; Intramural
   Research Program of the National Institute on Aging; National Institute
   on Aging and the National Heart, Lung, and Blood Institute [AG0005]
FX This research was supported by Grant T32-HL-069771-07 from the National
   Heart, Lung, and Blood Institute. The Coronary Artery Risk Development
   in Young Adults study is supported by contracts HHSN268201300025C,
   HHSN268201300026C, HHSN268201300027C, HHSN268201300028C,
   HHSN268201300029C, and HHSN268200900041C from the National Heart, Lung,
   and Blood Institute, the Intramural Research Program of the National
   Institute on Aging, and an intra-agency agreement between the National
   Institute on Aging and the National Heart, Lung, and Blood Institute
   (AG0005). A portion of this manuscript was presented at the American
   Heart Association Epidemiology and Prevention/Nutrition, Physical
   Activity and Metabolism 2013 Scientific Sessions. The authors have no
   conflicts of interest to disclose.
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NR 48
TC 15
Z9 16
U1 0
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0033-3174
EI 1534-7796
J9 PSYCHOSOM MED
JI Psychosom. Med.
PD SEP
PY 2016
VL 78
IS 7
BP 867
EP 873
DI 10.1097/PSY.0000000000000347
PG 7
WC Psychiatry; Psychology; Psychology, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry; Psychology
GA DW9RK
UT WOS:000383999400012
PM 27490849
OA Green Submitted, Green Accepted
DA 2025-06-11
ER

PT J
AU McElroy, SL
   Kotwal, R
   Malhotra, S
   Nelson, EB
   Keck, PE
   Nemeroff, CB
AF McElroy, SL
   Kotwal, R
   Malhotra, S
   Nelson, EB
   Keck, PE
   Nemeroff, CB
TI Are mood disorders and obesity related? A review for the mental health
   professional
SO JOURNAL OF CLINICAL PSYCHIATRY
LA English
DT Review
ID BINGE-EATING DISORDER; BODY-MASS INDEX; NUTRITION EXAMINATION SURVEY;
   MAJOR DEPRESSIVE DISORDER; WEIGHT-LOSS; CARDIOVASCULAR-DISEASE;
   PSYCHOSOCIAL-ASPECTS; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   BULIMIA-NERVOSA
AB Objective: We reviewed evidence regarding a possible relationship between mood disorders and obesity to better inform mental health professionals about their overlap.
   Method: We performed a MEDLINE search of the English-language literature for the years 1966-2003 using the following terms: obesity, overweight, abdominal, central, metabolic syndrome, depression, mania, bipolar disorder, binge eating, morbidity, mortality, cardiovascular, diabetes, cortisol, hypertriglyceridemia, sympathetic, family history, stimulant, sibutramine, antiobesity, antidepressant, topiramate, and zonisamide. We evaluated studies of obesity (and related conditions) in persons with mood disorders and of mood disorders in persons with obesity. We also compared studies of obesity and mood disorders regarding phenomenology, comorbidity, family history, biology, and pharmacologic treatment response.
   Results: The most rigorous clinical studies suggest that (1) children and adolescents with major depressive disorder may be at increased risk for developing overweight; (2) patients with bipolar disorder may have elevated rates of overweight, obesity, and abdominal obesity; and (3) obese persons seeking weight-loss treatment may have elevated rates of depressive and bipolar disorders. The most rigorous community studies suggest that (1) depression with atypical symptoms in females is significantly more likely to be associated with overweight than depression with typical symptoms; (2) obesity is associated with major depressive disorder in females; and (3) abdominal obesity may be associated with depressive symptoms in females and males; but (4) most overweight and obese persons in the community do not have mood disorders. Studies of phenomenology, comorbidity, family history, biology, and pharmacologic treatment response of mood disorders and obesity show that both conditions share many similarities along all of these indices.
   Conclusion: Although the overlap between mood disorders and obesity may be coincidental, it suggests the two conditions may be related. Clinical and theoretical implications of this overlap are discussed, and further research is called for.
C1 Univ Cincinnati, Coll Med, Dept Psychiat, Psychopharmacol Res Program, Cincinnati, OH 45267 USA.
   Univ Cincinnati, Coll Med, Eating Disorders Program, Cincinnati, OH 45267 USA.
   Univ Cincinnati, Coll Med, Obes Res & Treatment Program, Cincinnati, OH 45267 USA.
   United Hlth Network, Canton, OH USA.
   Emory Univ, Sch Med, Dept Psychiat & Behav Sci, Atlanta, GA 30322 USA.
C3 University System of Ohio; University of Cincinnati; University System
   of Ohio; University of Cincinnati; University System of Ohio; University
   of Cincinnati; Emory University
RP Univ Cincinnati, Coll Med, Dept Psychiat, Psychopharmacol Res Program, POB 670559,231 Albert Sabin Way, Cincinnati, OH 45267 USA.
EM susan.mcelroy@uc.edu
RI Nemeroff, Charles/AEU-9195-2022
OI Nemeroff, Charles/0000-0001-7867-1160
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NR 237
TC 456
Z9 522
U1 0
U2 102
PU PHYSICIANS POSTGRADUATE PRESS
PI MEMPHIS
PA P O BOX 752870, MEMPHIS, TN 38175-2870 USA
SN 0160-6689
EI 1555-2101
J9 J CLIN PSYCHIAT
JI J. Clin. Psychiatry
PD MAY
PY 2004
VL 65
IS 5
BP 634
EP 651
PG 18
WC Psychology, Clinical; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA 827GG
UT WOS:000221887100007
PM 15163249
DA 2025-06-11
ER

PT J
AU Tzeng, WC
   Chiang, YS
   Feng, HP
   Chien, WC
   Tai, YM
   Chen, MJ
AF Tzeng, Wen-Chii
   Chiang, Yu-Shuang
   Feng, Hsin-Pei
   Chien, Wu-Chien
   Tai, Yueh-Ming
   Chen, Mei-Jung
TI Gender differences in metabolic syndrome risk factors among patients
   with serious mental illness
SO INTERNATIONAL JOURNAL OF MENTAL HEALTH NURSING
LA English
DT Article
DE gender; mental illnesses; metabolic syndrome; prevalence; risk factors
ID MAJOR DEPRESSIVE DISORDER; AGE-SPECIFIC PREVALENCE; PHYSICAL-ACTIVITY;
   BIPOLAR DISORDER; SEDENTARY BEHAVIOR; NATIONAL-HEALTH; SCHIZOPHRENIA;
   ASSOCIATION; ADULTS; ABNORMALITIES
AB The prevalence of metabolic syndrome and its components continue to increase among patients with serious mental illness. This cross-sectional study investigated whether metabolic syndrome prevalence and risk factors differ between male and female patients with serious mental illness. In total, 260 eligible patients were recruited from two hospitals. The data on demographic characteristics, lifestyle behaviour factors, biochemistry, and anthropometry were collected. Analyses were performed using multivariate logistic regression. Metabolic syndrome prevalence was 40.8% (35.1% in men and 46.8% in women). Among patients aged 40-49 years, metabolic syndrome prevalence was higher in men; however, the trend was reversed among patients aged 50 years or older. Notably, gender-specific metabolic syndrome risk factors were observed. In men, they included low education level, high body mass index (BMI), prolonged illness, comorbid physical illness, and diagnosis of bipolar disorder, whereas they included being married, old age, and high BMI in women. Our findings suggest that mental health professionals should consider the gender- and age-based metabolic syndrome prevalence trend in patients with serious mental illness when designing interventions for the study population to minimize metabolic syndrome prevalence.
C1 [Tzeng, Wen-Chii] Natl Def Med Ctr, Sch Nursing, Box 90048-510, Taipei, Taiwan.
   [Chiang, Yu-Shuang] Triserv Gen Hosp, Natl Def Med Ctr, Dept Nursing, Beitou Branch, Taipei, Taiwan.
   [Feng, Hsin-Pei] Fu Jen Catholic Univ, Dept Nursing, New Taipei, Taiwan.
   [Chien, Wu-Chien] Triserv Gen Hosp, Dept Med Res, Taipei, Taiwan.
   [Chien, Wu-Chien] Natl Def Med Ctr, Sch Publ Hlth, Taipei, Taiwan.
   [Tai, Yueh-Ming] Triserv Gen Hosp, Natl Def Med Ctr, Dept Psychiat, Beitou Branch, Taipei, Taiwan.
   [Chen, Mei-Jung] Triserv Gen Hosp, Natl Def Med Ctr, Dept Nursing, Taipei, Taiwan.
C3 National Defense Medical Center; Tri-Service General Hospital; National
   Defense Medical Center; Fu Jen Catholic University; Tri-Service General
   Hospital; National Defense Medical Center; National Defense Medical
   Center; Tri-Service General Hospital; National Defense Medical Center;
   Tri-Service General Hospital
RP Tzeng, WC (corresponding author), Natl Def Med Ctr, Sch Nursing, Box 90048-510, Taipei, Taiwan.
EM wctzeng@mail.ndmctsgh.edu.tw
RI ; Tzeng, Wen-Chii/M-4214-2014
OI Tai, Yueh Ming/0000-0003-1076-3864; Tzeng, Wen-Chii/0000-0002-4205-896X
FU Tri-Service General Hospital, Taiwan [TSGH-C107-133] Funding Source:
   Medline
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NR 47
TC 10
Z9 11
U1 2
U2 10
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1445-8330
EI 1447-0349
J9 INT J MENT HEALTH NU
JI Int. J. Ment. Health Nurs.
PD APR
PY 2020
VL 29
IS 2
BP 254
EP 265
DI 10.1111/inm.12670
PG 12
WC Nursing; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Psychiatry
GA KT6RE
UT WOS:000519140700014
PM 31670454
DA 2025-06-11
ER

PT J
AU Shah, AS
   Pant, MR
   Bommasamudram, T
   Nayak, KR
   Roberts, SSH
   Gallagher, C
   Vaishali, K
   Edwards, B
   Tod, D
   Davis, F
   Pullinger, SA
AF Shah, Arambh Sanjay
   Pant, Mitresh Raj
   Bommasamudram, Tulasiram
   Nayak, Kirtana Raghurama
   Roberts, Spencer S. H.
   Gallagher, Chloe
   Vaishali, K.
   Edwards, Ben J.
   Tod, David
   Davis, Fiddy
   Pullinger, Samuel A.
TI Effects of Sleep Deprivation on Physical and Mental Health Outcomes: An
   Umbrella Review
SO AMERICAN JOURNAL OF LIFESTYLE MEDICINE
LA English
DT Review; Early Access
DE sleep deprivation; all-cause mortality; cardiovascular disease;
   metabolic syndrome; mental health
ID CORONARY-HEART-DISEASE; BLOOD-PRESSURE; DURATION; METAANALYSIS; RISK;
   ADULTS; MORTALITY; HYPERTENSION; STATEMENT; EMOTION
AB The increasing prevalence of reduced habitual sleep duration presents a significant public health challenge, impacting cardiovascular health, metabolic function and mental well-being. This umbrella review analyses findings from systematic reviews and meta-analyses to comprehensively evaluate the consequences of sleep deprivation (SD) on health. The databases searched included PubMed, Scopus, and Web of Science. Inclusion criteria focused on adult populations with SD and systematic reviews/meta-analyses. Twenty-nine articles were included in the final synthesis, encompassing a variety of health outcomes. Key findings highlight a U-shaped relationship between sleep duration and all-cause mortality, with both short (<7 h) sleep durations associated with increased risks. SD was a significant risk factor for cardiovascular diseases such as hypertension, stroke and coronary heart disease. Alongside heightened risks of metabolic disorders, like obesity and type 2 diabetes. Moreover, SD contributed to elevated anxiety levels, impaired emotional regulation. As well as increased susceptibility to stress and depressive symptoms. This synthesis underscores the critical importance of maintaining recommended sleep duration (typically 7-9 h for adults) to mitigate these health risks effectively. The findings support the need for robust public health interventions aimed at promoting healthy sleep habits to reduce the burden of associated health conditions and enhance overall well-being.
C1 [Shah, Arambh Sanjay; Pant, Mitresh Raj; Bommasamudram, Tulasiram] Manipal Acad Higher Educ, Manipal Coll Hlth Profess, Dept Exercise & Sports Sci, Manipal 576104, Karnataka, India.
   [Bommasamudram, Tulasiram; Roberts, Spencer S. H.] Deakin Univ, Inst Phys Act & Nutr IPAN, Ctr Sport Res CSR, Sch Exercise & Nutr Sci, Geelong, Australia.
   [Nayak, Kirtana Raghurama] Manipal Acad Higher Educ, Kasturba Med Coll, Dept Physiol, Manipal, India.
   [Gallagher, Chloe; Edwards, Ben J.] Liverpool John Moores Univ, Res Inst Sport & Exercise Sci, Liverpool, England.
   [Vaishali, K.] Manipal Acad Higher Educ, Manipal Coll Hlth Profess, Dept Physiotherapy, Manipal, India.
   [Tod, David] Univ Lancaster, Fac Hlth & Med, Lancaster, England.
   [Davis, Fiddy] Hope Coll, Kinesiol Dept, Holland, MI USA.
   [Pullinger, Samuel A.] Inspire Inst Sport, Sport Sci Dept, Bellar, India.
C3 Manipal Academy of Higher Education (MAHE); Deakin University; Manipal
   Academy of Higher Education (MAHE); Kasturba Medical College, Manipal;
   Liverpool John Moores University; Manipal Academy of Higher Education
   (MAHE); Lancaster University; Hope College
RP Bommasamudram, T (corresponding author), Manipal Acad Higher Educ, Manipal Coll Hlth Profess, Dept Exercise & Sports Sci, Manipal 576104, Karnataka, India.
EM tulasiram.b@manipal.edu
RI Pullinger, Samuel/AAD-6238-2019
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NR 61
TC 0
Z9 0
U1 1
U2 1
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1559-8276
EI 1559-8284
J9 AM J LIFESTYLE MED
JI Am. J. Lifestyle Med.
PD 2025 MAY 27
PY 2025
DI 10.1177/15598276251346752
EA MAY 2025
PG 15
WC Public, Environmental & Occupational Health
WE Emerging Sources Citation Index (ESCI)
SC Public, Environmental & Occupational Health
GA 3DS2M
UT WOS:001497885200001
PM 40443808
DA 2025-06-11
ER

PT J
AU Venu, L
   Harishankar, N
   Krishna, TP
   Raghunath, M
AF Venu, L
   Harishankar, N
   Krishna, TP
   Raghunath, M
TI Maternal dietary vitamin restriction increases body fat content but not
   insulin resistance in WNIN rat offspring up to 6 months of age
SO DIABETOLOGIA
LA English
DT Article
DE body fat; glucose tolerance; insulin resistance; maternal
   undernutrition; oxidative stress; rehabilitation; triglycerides;
   vitamins
ID IMPAIRED GLUCOSE-TOLERANCE; LOW-PROTEIN DIET; OXIDATIVE STRESS;
   BLOOD-PRESSURE; ADULT-RATS; GROWTH; FETAL; LEADS; HYPERINSULINEMIA;
   GLUTATHIONE
AB Aims/hypothesis. Epidemiological evidence suggests that some adult diseases like insulin resistance syndrome and diseases associated with it originate in fetal life. The role of maternal macronutrient malnutrition but not of micronutrients in the fetal origin of adult disease is well studied. We hypothesise that chronic maternal vitamin restriction predisposes the offspring to insulin resistance syndrome.
   Methods. Female weanling Wistar/NIN rats received a control diet (n=6) or a 50% vitamin-restricted diet (n=14) for 12 weeks and mated with control males. Four dams on the restricted diet were shifted to the control diet from parturition. Pups born to the remaining 10 dams on the restricted diet were weaned on to control diet or continued on the restricted diet. All groups had 8 male pups from weaning onwards.
   Results. Birthweights of pups were comparable among different groups. Weaning body weights were low in the restricted diet group, but on rehabilitation they caught up with control animals by post-natal day 100. None of the pups had impaired oral glucose tolerance and their insulin resistance status was comparable on days 40, 70, 100 and 180. Compared with offspring on the control diet, offspring on the restricted diet had a significantly higher percentage of body fat and higher plasma triglycerides, as well as lower lean body mass and fat-free mass. They also had increased oxidative stress. Rehabilitation from parturition or weaning prevented the changes in body fat percent, lean body mass, fat-free mass and oxidative stress.
   Conclusions/interpretation. Since changes in adiposity and fat metabolism are considered forerunners of insulin resistance syndrome, our observations suggest that maternal dietary vitamin restriction predisposes the offspring to insulin resistance syndrome in later life.
C1 Natl Inst Nutr, ICMR, Div Endocrinol & Metab, Hyderabad 500007, Andhra Pradesh, India.
   Natl Inst Nutr, ICMR, Natl Ctr Lab Anim Sci, Hyderabad 500007, Andhra Pradesh, India.
   Natl Inst Nutr, ICMR, Div Stat, Hyderabad 500007, Andhra Pradesh, India.
C3 Indian Council of Medical Research (ICMR); ICMR - National Institute of
   Nutrition (NIN); Indian Council of Medical Research (ICMR); ICMR -
   National Institute of Nutrition (NIN); ICMR - National Animal Resource
   Facility for Biomedical Research (NARFBR); Indian Council of Medical
   Research (ICMR); ICMR - National Institute of Nutrition (NIN)
RP Natl Inst Nutr, ICMR, Div Endocrinol & Metab, Jamai Osmania PO, Hyderabad 500007, Andhra Pradesh, India.
EM manchalar@yahoo.com
RI Lagishetty, Venu/C-8251-2009
OI Lagishetty, Venu/0000-0001-6500-8255
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NR 42
TC 45
Z9 51
U1 0
U2 1
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0012-186X
EI 1432-0428
J9 DIABETOLOGIA
JI Diabetologia
PD SEP
PY 2004
VL 47
IS 9
BP 1493
EP 1501
DI 10.1007/s00125-004-1506-4
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 863TE
UT WOS:000224584700004
PM 15365621
OA Bronze
DA 2025-06-11
ER

PT J
AU Sanjeevi, S
   Cocoman, A
AF Sanjeevi, Sujatha
   Cocoman, Angela
TI Mental Health Nurses' Knowledge of Clozapine
SO ISSUES IN MENTAL HEALTH NURSING
LA English
DT Article
ID METABOLIC SYNDROME; GASTROINTESTINAL HYPOMOTILITY; INDUCED MYOCARDITIS;
   JAPANESE PATIENTS; MEDICATION; SEIZURES; RISK
AB Clozapine, sold under the brand name Clozaril, is an antipsychotic medication prescribed since the 1970s as an effective treatment for individuals with treatment resistive schizophrenia. Medical experts have produced extensive literature on the need for close monitoring as this medication can cause life threatening adverse effects. Mental health nurses play a vital role in the management of clozapine, however to date just one study specifically examines psychiatric/mental health nurse's knowledge of this medication. Nurses need to be aware of the adverse effects and be able to provide psychoeducation to help support and inform clients prescribed this medication. This study used a survey questionnaire. A clozapine knowledge questionnaire with 18 questions was developed by De Hert et al. to explore psychiatric/mental health nurse's knowledge on the adverse effects of clozapine. We distributed a shortened version of this knowledge questionnaire (12-multi-choice questions) to 209 mental health nurses working within one Irish Mental Health Service. One hundred and twenty-nine (n = 129) nurses completed the questionnaire with a response rate of 62%. Our results indicated that over 40% of mental nurses had not received sufficient education on clozapine medication during their formal education. We found that just 50% of participants scored over six correct questions out of 12 questions on various areas of knowledge related to clozapine medication. We identified gaps in knowledge on clozapine medication in relation to on myocarditis, epilepsy and metabolic syndrome. We highlighted gaps in mental health nurses' knowledge of clozapine medication that need to be improved in order to help clients. We advocate additional education on clozapine medication at undergraduate education and through educational packages at the service level.
C1 [Sanjeevi, Sujatha; Cocoman, Angela] Dublin City Univ, Fac Sci & Hlth, Sch Nursing & Human Sci, Dublin 9, Ireland.
C3 Dublin City University
RP Cocoman, A (corresponding author), Dublin City Univ, Fac Sci & Hlth, Sch Nursing & Human Sci, Dublin 9, Ireland.
EM angela.cocoman@dcu.ie
RI Cocoman, Angela/V-9506-2019
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NR 51
TC 1
Z9 1
U1 1
U2 5
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 0161-2840
EI 1096-4673
J9 ISSUES MENT HEALTH N
JI Issues Ment. Health Nurs.
PD AUG 6
PY 2020
VL 42
IS 3
BP 291
EP 298
DI 10.1080/01612840.2020.1789786
EA AUG 2020
PG 8
WC Nursing; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Psychiatry
GA QR8YJ
UT WOS:000557589900001
PM 32762588
DA 2025-06-11
ER

PT J
AU Somerset, SM
   Graham, L
   Markwell, K
AF Somerset, S. M.
   Graham, L.
   Markwell, K.
TI Depression scores predict adherence in a dietary weight loss
   intervention trial
SO CLINICAL NUTRITION
LA English
DT Article
DE Depression; Adherence; Metabolic syndrome; Dropout; Dietary intervention
ID RANDOMIZED CONTROLLED-TRIALS; CLINICAL-TRIALS; CARDIOVASCULAR-DISEASES;
   STATISTICAL-METHODS; PHYSICAL-ACTIVITY; COMMUNITY-HEALTH; LOSS
   MAINTENANCE; BODY-COMPOSITION; AGED WOMEN; THERAPY
AB Background & aims: Depression has a complex association with cardiometabolic risk, both directly as an independent factor and indirectly through mediating effects on other risk factors such as BMI, diet, physical activity, and smoking. Since changes to many cardiometabolic risk factors involve behaviour change, the rise in depression prevalence as a major global health issue may present further challenges to long-term behaviour change to reduce such risk. This study investigated associations between depression scores and participation in a community-based weight management intervention trial.
   Methods: A group of 64 overweight (BMI > 27), otherwise healthy adults, were recruited and randomised to follow either their usual diet, or an isocaloric diet in which saturated fat was replaced with mono-unsaturated fat (MUFA), to a target of 50% total fat, by adding macadamia nuts to the diet. Subjects were assessed for depressive symptoms at baseline and at ten weeks using the Beck Depression Inventory (BDI-II). Both control and intervention groups received advice on National Guidelines for Physical Activity and adhered to the same protocol for food diary completion and trial consultations. Anthropometric and clinical measurements (cholesterol, inflammatory mediators) also were taken at baseline and 10 weeks.
   Results: During the recruitment phase, pre-existing diagnosed major depression was one of a range of reasons for initial exclusion of volunteers from the trial. Amongst enrolled participants, there was a significant correlation (R = -0.38, p < 0.05) between BDI-II scores at baseline and duration of participation in the trial. Subjects with a baseline BDI >= 10 (moderate to severe depression symptoms) were more likely to dropout of the trial before week 10 (p < 0.001). BDI-II scores in the intervention (MUFA) diet group decreased, but increased in the control group over the 10-week period. Univariate analysis of variance confirmed these observations (adjusted R-2 = 0.257, p = 0.01). Body weight remained static over the 10-week period in the intervention group, corresponding to a relative increase in the control group (adjusted R-2 = 0.097, p = 0.064).
   Conclusions: Depression symptoms have the potential to affect enrolment in and adherence to dietbased risk reduction interventions, and may consequently influence the generalisability of such trials. Depression scores may therefore be useful for characterising, screening and allocating subjects to appropriate treatment pathways. (C) 2011 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.
C1 [Somerset, S. M.] Griffith Univ, Sch Publ Hlth, Brisbane, Qld 4131, Australia.
   Griffith Univ, Griffith Hlth Inst, Brisbane, Qld 4131, Australia.
C3 Griffith University; Griffith University; Menzies Health Institute
   Queensland
RP Somerset, SM (corresponding author), Griffith Univ, Sch Publ Hlth, Brisbane, Qld 4131, Australia.
EM s.somerset@griffith.edu.au
RI Somerset, Shawn/K-4843-2014; Markwell, Katherine/C-4516-2012
OI Somerset, Shawn/0000-0002-4922-3593; Markwell,
   Katherine/0000-0001-6349-3525
FU Horticulture Australia [HAL 32633]; Griffith University
FX This project is supported by Horticulture Australia (HAL 32633) and
   listed with the Australia New Zealand Clinical Trial Registry
   (ACTRN12607000106437). Ethical Clearance was obtained through the
   Griffith University Human Research Ethics Committee (PBH/09/05/HREC). KM
   is supported by a Griffith University Postgraduate Research Scholarship.
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NR 54
TC 41
Z9 46
U1 0
U2 18
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0261-5614
EI 1532-1983
J9 CLIN NUTR
JI Clin. Nutr.
PD OCT
PY 2011
VL 30
IS 5
BP 593
EP 598
DI 10.1016/j.clnu.2011.04.004
PG 6
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nutrition & Dietetics
GA 846VE
UT WOS:000296930500009
PM 21575998
DA 2025-06-11
ER

PT J
AU Visier-Alfonso, ME
   Sánchez-López, M
   Bizzozero-Peroni, B
   Díaz-Goñi, V
   Cekrezi, S
   Suazo, I
   Martínez-Vizcaíno, V
AF Visier-Alfonso, Maria Eugenia
   Sanchez-Lopez, Mairena
   Bizzozero-Peroni, Bruno
   Diaz-Goni, Valentina
   Cekrezi, Shkelzen
   Suazo, Ivan
   Martinez-Vizcaino, Vicente
TI The impact and perceptions of standing desk interventions on movement
   patterns and physical, mental, and academic outcomes in university
   students: a scoping review
SO BMC PUBLIC HEALTH
LA English
DT Review
DE Sit-stand desks; University; Sedentary behavior; Physical activity;
   Classroom behavior; Cardiometabolic risk factors; Pain; Mental health;
   Cognition; Health
ID ENERGY-EXPENDITURE; SITTING TIME; WORKSTATIONS; ASSOCIATIONS; SEDENTARY
AB BackgroundThe use of standing desks may reduce sedentary behavior and, in turn, improve other health and academic outcomes. However, the evidence is sparse among university settings. The aim of this scoping review was to identify and map evidence for the effects of standing desk interventions on sedentary behavior and physical, mental, and academic outcomes in university students, as well as instructors and students' perceptions of this type of equipment in the classroom.MethodsA scoping review was conducted in accordance with the Joanna Briggs Institute and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Review guidelines. PubMed, Web of Science, Scopus, PsycINFO, PubPsych and ERIC databases were searched for qualitative and quantitative studies from their inception to 2024. Narrative synthesis and network plots were used to summarize the available evidence.ResultsSeventeen studies involving 2886 university students and 163 instructors were included. Fourteen studies were experimental and three were cross-sectional. In seven studies standing desks improved movement patterns (sitting and standing time in the classroom) and in four studies improved mental health outcomes (anxiety, mood, stress, and positive or negative feelings). Four studies analyzed pain and discomfort, one found significant improvements and three found mixed results. Eleven studies analyzed academic and classroom outcomes and seven found significant improvements in the standing desks group and five did not. Additionally, the use of standing desks was accepted and positively perceived by students in ten studies and by instructors in two.ConclusionsThe implementation of standing desks at university settings could be a behavioral intervention for improving movement patterns and mental health. However, the extant evidence is sparse; further long-term, high-quality trials are needed to draw robust conclusions.
C1 [Visier-Alfonso, Maria Eugenia; Sanchez-Lopez, Mairena; Bizzozero-Peroni, Bruno; Diaz-Goni, Valentina; Cekrezi, Shkelzen; Martinez-Vizcaino, Vicente] Univ Castilla La Mancha, Hlth & Social Res Ctr, Cuenca, Spain.
   [Visier-Alfonso, Maria Eugenia] Univ Castilla La Mancha, Fac Enfermeria Cuenca, Cuenca, Spain.
   [Sanchez-Lopez, Mairena] Univ Castilla La Mancha, Fac Educ, Ciudad Real, Spain.
   [Bizzozero-Peroni, Bruno] Univ Republ, Inst Super Educ Fis, Rivera, Uruguay.
   [Suazo, Ivan; Martinez-Vizcaino, Vicente] Univ Autonoma Chile, Fac Ciencias Salud, Santiago, Chile.
C3 Universidad de Castilla-La Mancha; Universidad de Castilla-La Mancha;
   Universidad de Castilla-La Mancha; Universidad de la Republica, Uruguay;
   Universidad Autonoma de Chile
RP Bizzozero-Peroni, B (corresponding author), Univ Castilla La Mancha, Hlth & Social Res Ctr, Cuenca, Spain.; Bizzozero-Peroni, B (corresponding author), Univ Republ, Inst Super Educ Fis, Rivera, Uruguay.
EM Bruno.Bizzozero@uclm.es
RI Díaz Goñi, Valentina/CAA-8173-2022; VIZCAINO, VICENTE/R-4336-2017;
   Visier-Alfonso, María Eugenia/AAZ-5925-2021; Suazo, Iván/AAW-9318-2020;
   Bizzozero-Peroni, Bruno/AAL-1110-2020
FU Universidad de Castilla-La Mancha
FX Not applicable.
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NR 56
TC 0
Z9 0
U1 0
U2 0
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2458
J9 BMC PUBLIC HEALTH
JI BMC Public Health
PD MAY 9
PY 2025
VL 25
IS 1
AR 1726
DI 10.1186/s12889-025-22912-z
PG 17
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA 2MA5Y
UT WOS:001485860900003
PM 40346487
OA gold
DA 2025-06-11
ER

PT J
AU Akbar, Z
   Shi, ZM
AF Akbar, Zoha
   Shi, Zumin
TI Unfavorable Mealtime, Meal Skipping, and Shiftwork Are Associated with
   Circadian Syndrome in Adults Participating in NHANES 2005-2016
SO NUTRIENTS
LA English
DT Article
DE diet; mealtime; meal skipping; shiftwork; chrononutrition; circadian
   rhythms; circadian syndrome; NHANES
ID NONSEASONAL DEPRESSION; METABOLIC SYNDROME; GENE-EXPRESSION; LIGHT
   THERAPY; HEALTHY; TIME; DISRUPTION; FREQUENCY; EFFICACY; RHYTHMS
AB The concept of Circadian Syndrome (CircS) aims to emphasize the circadian disruptions underlying cardiometabolic conditions. Meal timing and shiftwork may disrupt circadian rhythms, increasing cardiometabolic risk. This study aimed to assess the associations of meal timing, meal skipping, and shiftwork with CircS in US adults and explore effect modifications by sociodemographic and lifestyle factors. CircS was defined using Metabolic Syndrome components in addition to short sleep and depression symptoms. Data from 10,486 participants of the National Health and Nutrition Examination Survey 2005-2016 were analyzed cross-sectionally. Mealtime was assessed by calculating the midpoint of intake between breakfast and dinner and dichotomizing it into favorable mealtime (between 12:30 and 13:15) and unfavorable mealtime using a data-driven approach. Meal skippers were categorized separately. Participants working evening, night, or rotating shifts were classified as shift workers. In the multivariable logistic regression analysis, an unfavorable mealtime, meal skipping, and shiftwork were associated with a higher likelihood of CircS (OR = 1.24; 95%CI 1.07-1.44, OR = 1.39; 95%CI 1.16-1.67, and OR = 1.37; 95%CI 1.01-1.87, respectively). Subgroup analyses revealed no significant interactions between meal timing, meal skipping, or shiftwork and socioeconomic status or lifestyle regarding CircS. These findings highlight the importance of aligning mealtimes with circadian rhythms for improved circadian health.
C1 [Akbar, Zoha; Shi, Zumin] Qatar Univ, Coll Hlth Sci, Human Nutr Dept, QU Hlth, POB 2713, Doha, Qatar.
C3 Qatar University
RP Shi, ZM (corresponding author), Qatar Univ, Coll Hlth Sci, Human Nutr Dept, QU Hlth, POB 2713, Doha, Qatar.
EM za1404491@qu.edu.qa; zumin@qu.edu.qa
RI Shi, Zumin/A-1093-2009
OI Shi, Zumin/0000-0002-3099-3299
FU Qatar University
FX Authors would like to thank Qatar University and the Grant Office for
   funding this work.
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NR 55
TC 3
Z9 3
U1 3
U2 8
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JUN
PY 2024
VL 16
IS 11
AR 1581
DI 10.3390/nu16111581
PG 14
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA UB9N9
UT WOS:001245720700001
PM 38892514
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Chung, HS
   Hwang, HJ
   Hwang, SY
   Kim, NH
   Seo, JA
   Kim, SG
   Kim, NH
   Baik, SH
   Choi, KM
   Yoo, HJ
AF Chung, Hye Soo
   Hwang, Hwan-Jin
   Hwang, Soon Young
   Kim, Nam Hoon
   Seo, Ji A.
   Kim, Sin Gon
   Kim, Nan Hee
   Baik, Sei Hyun
   Choi, Kyung Mook
   Yoo, Hye Jin
TI Association of serum Sestrin2 level with metabolic risk factors in newly
   diagnosed drug-naive type 2 diabetes
SO DIABETES RESEARCH AND CLINICAL PRACTICE
LA English
DT Article
DE Sestrin2; Type 2 diabetes mellitus; Metabolic syndrome; Atherosclerosis
ID C-REACTIVE PROTEIN; PULSE-WAVE VELOCITY; INSULIN-RESISTANCE; STRESS;
   HOMEOSTASIS; DISEASE; OBESE
AB Aims: Previous in-vitro and in-vivo experimental studies have shown that Sestrin2 attenuates oxidative stress and the pro-inflammatory pathway, resulting in improving metabolic homeostasis. However, the relationship between circulating Sestrin2 concentration and cardiometabolic risks in humans has not been explored.
   Methods: Sestrin2 concentration was measured in 240 subjects (46 without diabetes and 194 with diabetes), and the associations between Sestrin2 level and various cardiometabolic risk factors including body composition, insulin resistance, and atherosclerosis was assessed.
   Results: Sestrin2 concentration showed a trend of increasing in subjects with metabolic syndrome. After adjustment for age and gender, Sestrin2 level had a positive relationship with serum triglyceride, alanine aminotransferase (ALT), and creatinine levels, but no association with carotid atherosclerosis. Especially, in subjects with type 2 diabetes Sestrin2 concentration exhibited a significant positive correlation with body mass index (P = 0.015), waist circumference (P = 0.020), high-sensitivity C-reactive protein (P = 0.008), Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) (P = 0.041), percentage body fat (P = 0.001), and truncal fat mass (P = 0.005) after adjusting age and gender. Multiple stepwise regression analysis identified age, serum ALT and creatinine levels, and percentage body fat as independent determining factors for Sestrin2 concentration in patients with type 2 diabetes (R-2 = 0.173).
   Conclusions: This study is the first to demonstrate a trend for increased Sestrin2 level in subjects with metabolic syndrome. In particular, in subjects with type 2 diabetes, Sestrin2 was significantly related to insulin resistance and percentage body fat, suggesting its potential as a novel modulatory factor for metabolic disorders in humans. (C) 2018 Elsevier B.V. All rights reserved.
C1 [Chung, Hye Soo; Hwang, Hwan-Jin; Kim, Nam Hoon; Seo, Ji A.; Kim, Sin Gon; Kim, Nan Hee; Baik, Sei Hyun; Choi, Kyung Mook; Yoo, Hye Jin] Korea Univ, Dept Internal Med, Div Endocrinol & Metab, Coll Med, Seoul, South Korea.
   [Chung, Hye Soo] Hallym Univ, Dept Internal Med, Div Endocrinol & Metab, Coll Med,Kangnam Sacred Heart Hosp, Seoul, South Korea.
   [Hwang, Soon Young] Korea Univ, Coll Med, Dept Biostat, Seoul, South Korea.
C3 Korea University; Korea University Medicine (KU Medicine); Hallym
   University; Korea University; Korea University Medicine (KU Medicine)
RP Yoo, HJ (corresponding author), Korea Univ, Div Endocrinol & Metab, Dept Internal Med, Guro Hosp,Coll Med, 80 Guro Dong, Seoul 152703, South Korea.
EM deisy21@naver.com
RI Kim, Sin Gon/KQU-7757-2024; Choi, Kyung/C-4195-2018; Chung,
   Hye/AAG-8591-2020; Kim, Nan/T-8627-2019; Kim, Nam Hoon/HNS-5794-2023;
   SEO, JI/AAU-7968-2020
OI Chung, Hye Soo/0000-0003-0819-5167; Kim, Nan Hee/0000-0003-4378-520X;
   Choi, Kyung Mook/0000-0001-6175-0225; Kim, Nam Hoon/0000-0002-9926-1344;
   Kim, Sin Gon/0000-0002-7430-3675
FU National Research Foundation of Korea (NRF) - Ministry of Education,
   Science and Technology [2015R1A1A1A05001173]; Korea University Guro
   Hospital Grant [O1700421]
FX Dr. H.J. Yoo was supported by the Basic Science Research Program through
   the National Research Foundation of Korea (NRF), which is funded by the
   Ministry of Education, Science and Technology (2015R1A1A1A05001173) and
   a Korea University Guro Hospital Grant (O1700421).
CR Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
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NR 28
TC 29
Z9 31
U1 0
U2 5
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0168-8227
EI 1872-8227
J9 DIABETES RES CLIN PR
JI Diabetes Res. Clin. Pract.
PD OCT
PY 2018
VL 144
BP 34
EP 41
DI 10.1016/j.diabres.2018.07.024
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA GX4YU
UT WOS:000447746400005
PM 30099048
DA 2025-06-11
ER

PT J
AU Calcaterra, V
   De Giuseppe, R
   Biino, G
   Mantelli, M
   Marchini, S
   Bendotti, G
   Madè, A
   Avanzini, MA
   Montalbano, C
   Cossellu, G
   Larizza, D
   Cena, H
AF Calcaterra, Valeria
   De Giuseppe, Rachele
   Biino, Ginevra
   Mantelli, Melissa
   Marchini, Sonia
   Bendotti, Giulia
   Made, Alexandra
   Avanzini, Maria Antonietta
   Montalbano, Chiara
   Cossellu, Gianguido
   Larizza, Daniela
   Cena, Hellas
TI Relation between circulating oxidized-LDL and metabolic syndrome in
   children with obesity: the role of hypertriglyceridemic waist phenotype
SO JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
LA English
DT Article
DE children; metabolic syndrome (MetS); obesity; oxidative damage;
   oxidized-low-density lipoproteins (Ox-LDL)
ID OXIDATIVE STRESS; INSULIN-RESISTANCE; PUBERTAL CHANGES; ADOLESCENTS;
   OVERWEIGHT; INFLAMMATION; MARKERS; PATTERN; TRAITS; INDEX
AB Background: The association between oxidative stress (OS) and metabolic syndrome (MetS) has been reported in adults. We analyzed the relation between circulating oxidized low-density lipoproteins (Ox-LDL) and MetS in pediatric ages in order to define whether plasma Ox-LDL levels are correlated to obesity and whether oxidative damage, using serum Ox-LDL levels as a proxy, are associated with MetS.
   Methods: We enrolled 178 children (11.8 +/- 2.6 years). On the basis of a body mass index (BMI) threshold, the subjects were classified as: normal weight BMI < 75th percentile; overweight BMI 75-97th percentile; obese BMI > 97th percentile. Patients were classified as having MetS if they met three or more of the following criteria for age and sex: BMI > 97th percentile, triglyceride levels > 95th percentile, high-density lipoprotein (HDL) cholesterol level < 5th percentile, systolic blood pressure (SBP) and/or diastolic blood pressure (DBP) > 95th percentile and impaired glucose tolerance.
   Results: Obese children showed increased MetS prevalence (p = 0.001) and higher Ox-LDL levels compared to normal-and overweight subjects (p < 0.05), with a limited relation between Ox-LDL and MetS (p = 0.06). Waist-to-height ratio (W/HtR) (p = 0.02), triglycerides (TG) (p = 0.001) and LDL-cholesterol (p < 0.001) resulted independent predictors of increased plasma Ox-LDL levels.
   Conclusions: Oxidative damage was correlated with a hypertriglyceridemic waist phenotype and can be a precocious marker of MetS and cardiometabolic risk in obese children.
C1 [Calcaterra, Valeria] Fdn IRCCS Policlin S Matteo, Dept Maternal & Childrens Hlth, Pediat Endocrinol Unit, Ple Golgi 2, I-27100 Pavia, Italy.
   [Calcaterra, Valeria] Univ Pavia, Dept Internal Med, Ple Golgi 2, I-27100 Pavia, Italy.
   [De Giuseppe, Rachele; Marchini, Sonia; Bendotti, Giulia; Cena, Hellas] Univ Pavia, Dept Publ Hlth Expt & Forens Med, Unit Human Nutr & Dietet, Pavia, Italy.
   [Biino, Ginevra] Natl Res Council Italy, Inst Mol Genet, Pavia, Italy.
   [Mantelli, Melissa; Avanzini, Maria Antonietta] Fdn IRCCS Policlin S Matteo, Immunol & Transplantat Lab, Cell Factory Pediat Hematol Oncol Dept, Pavia, Italy.
   [Made, Alexandra; Montalbano, Chiara; Larizza, Daniela] Univ Pavia, Dept Internal Med, Pediat Endocrinol Unit, Pavia, Italy.
   [Made, Alexandra; Montalbano, Chiara; Larizza, Daniela] Fdn IRCCS Policlin San Matteo, Dept Maternal & Child Hlth, Pavia, Italy.
   [Cossellu, Gianguido] Univ Milan, Fdn IRCCS Ca Granda, Dept Biomed Surg & Dent Sci, Osped Maggiore Policlin, Milan, Italy.
C3 IRCCS Fondazione San Matteo; University of Pavia; University of Pavia;
   Consiglio Nazionale delle Ricerche (CNR); Istituto di Genetica
   Molecolare (IGM-CNR); IRCCS Fondazione San Matteo; University of Pavia;
   IRCCS Fondazione San Matteo; University of Milan; IRCCS Ca Granda
   Ospedale Maggiore Policlinico
RP Calcaterra, V (corresponding author), Fdn IRCCS Policlin S Matteo, Dept Maternal & Childrens Hlth, Pediat Endocrinol Unit, Ple Golgi 2, I-27100 Pavia, Italy.; Calcaterra, V (corresponding author), Univ Pavia, Dept Internal Med, Ple Golgi 2, I-27100 Pavia, Italy.
EM v.calcaterra@smatteo.pv.it
RI Calcaterra, Valeria/AAB-7563-2022; De Giuseppe, Rachele/K-4899-2018;
   Bendotti, Giulia/AAB-8375-2022; avanzini, maria antonietta/K-7839-2016;
   BIINO, GINEVRA/B-5334-2013; Cena, Hellas/AAB-9995-2019
OI Mantelli, Melissa/0000-0001-9945-1861; De Giuseppe,
   Rachele/0000-0002-5583-7735; Cossellu, Gianguido/0000-0001-6442-5591;
   CALCATERRA, VALERIA/0000-0002-2137-5974; Bendotti,
   Giulia/0000-0002-6548-3475; avanzini, maria
   antonietta/0000-0002-6056-9018; BIINO, GINEVRA/0000-0002-9936-946X;
   Cena, Hellas/0000-0002-5752-6199
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NR 33
TC 28
Z9 29
U1 0
U2 2
PU WALTER DE GRUYTER GMBH
PI BERLIN
PA GENTHINER STRASSE 13, D-10785 BERLIN, GERMANY
SN 0334-018X
EI 2191-0251
J9 J PEDIATR ENDOCR MET
JI J. Pediatr. Endocrinol. Metab.
PD DEC
PY 2017
VL 30
IS 12
BP 1257
EP 1263
DI 10.1515/jpem-017-0239
PG 7
WC Endocrinology & Metabolism; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Pediatrics
GA FO2LO
UT WOS:000416610500004
PM 29127769
DA 2025-06-11
ER

PT J
AU Eid, BG
   Neamatallah, T
   Binmahfouz, LS
   Bagher, AM
   Alamoudi, AJ
   Aldawsari, HM
   Hanafy, A
   Hasan, A
   El-Bassossy, HM
   Abdel-Naim, AB
   Vemuri, K
   Makriyannis, A
AF Eid, Basma G.
   Neamatallah, Thikryat
   Binmahfouz, Lenah S.
   Bagher, Amina M.
   Alamoudi, Abdulmohsin J.
   Aldawsari, Hibah Mubarak
   Hanafy, Abeer
   Hasan, Atif
   El-Bassossy, Hany M.
   Abdel-Naim, Ashraf B.
   Vemuri, Kiran
   Makriyannis, Alexandros
TI Effects of the CB1 receptor antagonists AM6545 and AM4113 on metabolic
   syndrome-induced prostatic hyperplasia in rats
SO BIOMOLECULES AND BIOMEDICINE
LA English
DT Article
DE AM6545; AM4113; prostate; cannabinoid antagonist; metabolic syndrome
   (MetS)
ID URINARY-TRACT SYMPTOMS; OXIDATIVE STRESS; CARDIOMETABOLIC RISK;
   BODY-WEIGHT; FOOD-INTAKE; RIMONABANT; OBESITY; MANAGEMENT; DISEASE;
   MODELS
AB Metabolic syndrome (MetS) is a combination of metabolic disorders that can predispose individuals to benign prostatic hyperplasia (BPH). The inhibition of the cannabinoid 1 (CB1) receptor has been used to treat metabolic disorders in animal models. This study reports the use of a peripherally restricted CB1 antagonist (AM6545) and a neutral CB1 antagonist (AM4113) to improve MetS-related BPH in rats. Animals were divided into three control groups to receive either a normal rodent diet, AM6545, or AM4113. MetS was induced in the fourth, fifth, and sixth groups using a concentrated fructose solution and high-salt diet delivered as food pellets for eight weeks. The fifth and sixth groups were further given AM6545 or AM4113 for additional four weeks. Body and prostate weights were measured and prostate sections were stained with hematoxylin eosin. Cyclin D1, markers of oxidative stress and inflammation, and levels of the endocannabinoids were recorded. BPH in rats with MetS was confirmed through increased prostate weight and index, as well as histopathology. Treatment with either AM6545 or AM4113 significantly decreased prostate weight, improved prostate histology, and reduced cyclin D1 expression compared with the MetS group. Groups treated with CB1 antagonists experienced reduced lipid peroxidation, recovered glutathione depletion, restored catalase activity, and had lower inflammatory markers interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-alpha). MetS rats treated with either AM6545 or AM4113 showed reduced concentrations of anandamide (AEA) and 2-arachidonoylglycerol (2-AG) in the prostate compared with the MetS group. In conclusion, the CB1 antagonists AM6545 and AM4113 protect against MetS-induced BPH through their anti-proliferative, antioxidant, and anti-inflammatory effects.
C1 [Eid, Basma G.; Neamatallah, Thikryat; Binmahfouz, Lenah S.; Bagher, Amina M.; Alamoudi, Abdulmohsin J.; Hanafy, Abeer; Abdel-Naim, Ashraf B.] King Abdulaziz Univ, Dept Pharmacol & Toxicol, Fac Pharm, Jeddah, Saudi Arabia.
   [Aldawsari, Hibah Mubarak] King Abdulaziz Univ, Dept Pharmaceut, Fac Pharm, Jeddah, Saudi Arabia.
   [Hanafy, Abeer] Kafrelsheikh Univ, Dept Pharmacol, Fac Vet Med, Kafrelsheikh, Egypt.
   [Hasan, Atif] Kafrelsheikh Univ, Dept Anat & Embryol, Fac Vet Med, Kafrelsheikh, Egypt.
   [El-Bassossy, Hany M.] Zagazig Univ, Dept Pharmacol & Toxicol, Fac Pharm, Zagazig, Egypt.
   [Vemuri, Kiran; Makriyannis, Alexandros] Northeastern Univ, Ctr Drug Discovery, Boston, MA USA.
   [Makriyannis, Alexandros] Northeastern Univ, Dept Chem & Chem Biol, Boston, MA USA.
   [Makriyannis, Alexandros] Northeastern Univ, Dept Pharmaceut Sci, Boston, MA USA.
C3 King Abdulaziz University; King Abdulaziz University; Egyptian Knowledge
   Bank (EKB); Kafrelsheikh University; Egyptian Knowledge Bank (EKB);
   Kafrelsheikh University; Egyptian Knowledge Bank (EKB); Zagazig
   University; Northeastern University; Northeastern University;
   Northeastern University
RP Eid, BG (corresponding author), King Abdulaziz Univ, Dept Pharmacol & Toxicol, Fac Pharm, Jeddah, Saudi Arabia.
EM beid@kau.edu.sa
RI El-Bassossy, Hany/NKQ-3705-2025; Aldawsari, Hibah/U-1571-2019;
   Binmahfouz, Lenah/AAV-7601-2020; Neamatallah, Thikryat/L-7201-2016;
   Bagher, Amina/F-1702-2018; Abdel-Naim, Ashraf/J-3199-2012; Eid,
   Basma/F-3962-2018; El-Bassossy, Hany/I-1576-2012; Alamoudi,
   Abdulmohsin/B-6830-2019
OI Eid, Basma/0000-0002-8244-1242; El-Bassossy, Hany/0000-0002-6838-6945;
   Bagher, Amina M./0000-0002-1850-5686; Alamoudi,
   Abdulmohsin/0000-0002-9028-8225; Binmahfouz, Lenah/0000-0002-5142-0588
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NR 49
TC 0
Z9 0
U1 1
U2 7
PU ASSOC BASIC MEDICAL SCI FEDERATION BOSNIA & HERZEGOVINA SARAJEVO
PI CEKALUSA
PA UNIV SARAJEVO, MEDICAL FAC, CEKALUSA, SARAJEVO 90, BOSNIA & HERCEG
SN 2831-0896
EI 2831-090X
J9 BIOMOL BIOMED
JI Biomol. Biomed.
PY 2023
VL 23
IS 6
BP 1069
EP 1078
DI 10.17305/bb.2023.9173
PG 10
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA X9AT2
UT WOS:001101302800013
PM 37212036
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Vogelzangs, N
   Beekman, ATF
   Kritchevsky, SB
   Newman, AB
   Pahor, M
   Yaffe, K
   Rubin, SM
   Harris, TB
   Satterfield, S
   Simonsick, EM
   Penninx, BWJH
AF Vogelzangs, Nicole
   Beekman, Aartjan T. F.
   Kritchevsky, Stephen B.
   Newman, Anne B.
   Pahor, Marco
   Yaffe, Kristine
   Rubin, Susan M.
   Harris, Tamara B.
   Satterfield, Suzanne
   Simonsick, Eleanor M.
   Penninx, Brenda W. J. H.
TI Psychosocial risk factors and the metabolic syndrome in elderly persons:
   Findings from the health, aging and body composition study
SO JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL
   SCIENCES
LA English
DT Article
ID CORONARY-HEART-DISEASE; 3RD NATIONAL-HEALTH;
   DEHYDROEPIANDROSTERONE-SULFATE; CARDIOVASCULAR-DISEASE;
   MYOCARDIAL-INFARCTION; INSULIN-RESISTANCE; DEPRESSED MOOD; STRESS;
   PREVALENCE; MORTALITY
AB Background. Psychosocial factors have been associated with metabolic abnormalities that increase the risk of cardiovascular disease and diabetes. This study investigated the cross-sectional relationship between psychosocial risk factors and the metabolic syndrome in a community-based sample of older persons.
   Methods. Participants were 2917 persons aged 70-79 years enrolled in the Health, Aging and Body Composition study. Depressive and anxiety symptoms, negative life events, and inadequate emotional support were assessed, and a summary psychosocial risk index was calculated. Metabolic syndrome was defined as three or more of the following criteria: abdominal obesity, high triglycerides, low high-density lipoprotein (HDL cholesterol, high fasting glucose, and high blood pressure.
   Results. Negative life events and inadequate emotional support increased the odds of having metabolic syndrome after adjustment for demographic and lifestyle variables (odds ratio [OR] per life event = 1.13, 95% confidence interval [CI] = 1.05-1.22; OR = 1.35, 95% CI = 1.10-1.66, respectively). The relationship between depressive symptoms and metabolic syndrome was only found in white (OR per standard deviation [SD] = 1.11, 95% CI = 1.0 1-1.23), but not in black (OR per SD = 0.97, 95% CI = 0.86-1.11) persons. Anxiety symptoms were significantly associated with metabolic syndrome in men (OR per SD = 1.13, 95% CI = 1.00-1.28), but not in women (OR per SD = 0.98, 95% CI = 0.89-1.08). Moreover, a higher score on the psychosocial risk index was associated with an increased probability of having the metabolic syndrome (OR = 1.30, 95% CI = 1.12-1.52).
   Conclusions. In the elderly population, different psychosocial risk factors are associated with a higher prevalence of the metabolic syndrome. Whether reduction or better management of psychosocial risk factors can improve the metabolic profile remains to be demonstrated.
C1 Vrije Univ Amsterdam Med Ctr, Dept Psychiat, NL-1081 HJ Amsterdam, Netherlands.
   Vrije Univ Amsterdam Med Ctr, Inst Res Extramural Med, NL-1081 HJ Amsterdam, Netherlands.
   Wake Forest Univ, Bowman Gray Sch Med, Winston Salem, NC USA.
   Univ Pittsburgh, Pittsburgh, PA 15260 USA.
   Univ Florida, Gainesville, FL USA.
   Vet Affairs Med Ctr, Gainesville, FL 32608 USA.
   Univ Calif San Francisco, San Francisco, CA 94143 USA.
   NIA, Bethesda, MD 20892 USA.
   Univ Tennessee, Memphis, TN USA.
   NIA, Baltimore, MD 21224 USA.
C3 Vrije Universiteit Amsterdam; VU UNIVERSITY MEDICAL CENTER; Vrije
   Universiteit Amsterdam; VU UNIVERSITY MEDICAL CENTER; Wake Forest
   University; Wake Forest Baptist Medical Center; Pennsylvania
   Commonwealth System of Higher Education (PCSHE); University of
   Pittsburgh; State University System of Florida; University of Florida;
   US Department of Veterans Affairs; Veterans Health Administration (VHA);
   University of California System; University of California San Francisco;
   National Institutes of Health (NIH) - USA; NIH National Institute on
   Aging (NIA); University of Tennessee System; University of Tennessee
   Health Science Center; National Institutes of Health (NIH) - USA; NIH
   National Institute on Aging (NIA)
RP Vogelzangs, N (corresponding author), Vrije Univ Amsterdam Med Ctr, Dept Psychiat, Oldenaller 1, NL-1081 HJ Amsterdam, Netherlands.
EM nicolev@ggzba.nl
RI Simonsick, Eleanor/W-6864-2019; Yaffe, Kristine/LLL-8209-2024;
   Kritchevsky, Stephen/JWP-7971-2024; Penninx, Brenda/S-7627-2017;
   Beekman, Aartjan T./LUZ-6919-2024; Newman, Anne B./C-6408-2013
OI Newman, Anne B./0000-0002-0106-1150; Kritchevsky,
   Stephen/0000-0003-3336-6781
FU NHLBI NIH HHS [1R01-HL972972] Funding Source: Medline; NIA NIH HHS
   [N01-AG-6-2103, N01-AG-6-2101, N01-AG-6-2106] Funding Source: Medline;
   Intramural NIH HHS Funding Source: Medline
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NR 36
TC 69
Z9 74
U1 0
U2 5
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1079-5006
EI 1758-535X
J9 J GERONTOL A-BIOL
JI J. Gerontol. Ser. A-Biol. Sci. Med. Sci.
PD MAY
PY 2007
VL 62
IS 5
BP 563
EP 569
DI 10.1093/gerona/62.5.563
PG 7
WC Geriatrics & Gerontology; Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA 228WP
UT WOS:000250763600014
PM 17522363
OA Green Submitted, Bronze
DA 2025-06-11
ER

PT J
AU da Silva, JSC
   Silva, MS
   Naves, MMV
AF da Silva, John Sebastiao Cardoso
   Silva, Maria Sebastiana
   Naves, Maria Margareth Veloso
TI Baru Nut Intake and Resistance Training Practice have Potential to
   Reduce the Cardiometabolic Risk Factors in Type 2 Diabetes
SO CURRENT NUTRITION & FOOD SCIENCE
LA English
DT Review
DE Type 2 diabetes mellitus; metabolic diseases; Dipteryx alata Vog; nuts;
   physical exercise; resistance training
ID DIPTERYX-ALATA-VOG.; OXIDATIVE STRESS; CARDIOVASCULAR-DISEASE;
   CHEMICAL-COMPOSITION; METABOLIC SYNDROME; IMPAIRED GLUCOSE;
   BODY-COMPOSITION; GLYCEMIC CONTROL; OLDER-ADULTS; FATTY-ACIDS
AB Background: Type 2 diabetes mellitus (T2DM) is a disease associated with several cardiometabolic risk factors (CMRF). There is strong evidence about the benefits of oilseeds intake and the practice of resistance training (RT) in the prevention and treatment of T2DM and its associated CMRF. However, no study has evaluated the combination of these interventions yet. Baru nut, an oilseed native to the Brazilian Cerrado, stands out among oilseeds due to its healthy nutritional composition, which has the potential to reduce CMRF in T2DM. RT, in turn, provides positive changes in the composition and metabolism of muscle cells, which contributes to improving cardiometabolic health.
   Objective: This review aimed to summarize the effects and mechanisms related to the intake of baru nut and the practice of RT in reducing CMRF in T2DM.
   Methods: Literature research was performed using the keywords "type 2 diabetes mellitus", "Dipteryx alata Vog", "nuts", "physical exercise" and "resistance training", isolated or associated, in Web of Science and Pubmed databases.
   Results: Baru nut is oilseed with a high density of nutrients and bioactive compounds with antioxidant and antihypercholesterolemic properties, and the RT is associated with beneficial effects on CMRF of individuals with T2DM. Thus, the consumption of baru nut and the RT have the potential to improve insulin sensitivity, glycemic control, body composition, and serum lipid profile.
   Conclusion: The baru nut consumption and the RT have the potential to reduce the cardiometabolic risk factors in T2DM. Both interventions are innovative and promising approaches to preserve the health of individuals with T2DM.
C1 [da Silva, John Sebastiao Cardoso; Naves, Maria Margareth Veloso] Univ Fed Goias UFG, Fac Nutr, BR-74605080 Goiania, Go, Brazil.
   [Silva, Maria Sebastiana] Univ Fed Goias UFG, Escola Educ Fis, Campus Samambaia, BR-74001970 Goiania, Go, Brazil.
RP Naves, MMV (corresponding author), Univ Fed Goias UFG, Rua 227,S-N St Leste Univ, BR-74605080 Goiania, Go, Brazil.
EM maria_margareth_veloso@ufg.br
RI Silva, Maria/IQV-6559-2023; Naves, Maria/I-4828-2015
OI Silva, Maria Sebastiana/0000-0001-7265-5872; Naves, Maria
   Margareth/0000-0003-4332-6206; Sebastiao Cardoso da Silva,
   John/0000-0002-7018-5173
FU Graduate Program in Nutrition and Health (PPGNUT)
FX The authors thank the Graduate Program in Nutrition and Health (PPGNUT)
   and the Laboratory of Experimental Nu-trition (LANUTE) , School of
   Nutrition, Federal University of Goias (Universidade Federal de
   Goias-UFG) , for the administrative and technical support.
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NR 80
TC 0
Z9 0
U1 0
U2 2
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1573-4013
EI 2212-3881
J9 CURR NUTR FOOD SCI
JI Curr. Nutr. Food Sci.
PY 2021
VL 17
IS 9
BP 911
EP 921
DI 10.2174/1573401317666210420122023
PG 11
WC Nutrition & Dietetics
WE Emerging Sources Citation Index (ESCI)
SC Nutrition & Dietetics
GA WK2HU
UT WOS:000709552900003
DA 2025-06-11
ER

PT J
AU Plever, S
   McCarthy, I
   Anzolin, M
   Emmerson, B
   Khatun, M
AF Plever, Sally
   McCarthy, Irene
   Anzolin, Melissa
   Emmerson, Brett
   Khatun, Mohsina
TI A collaborative approach to improve the assessment of physical health in
   adult consumers with schizophrenia in Queensland mental health services
SO AUSTRALASIAN PSYCHIATRY
LA English
DT Article
DE mental health; physical health; schizophrenia; collaborative
ID METABOLIC SYNDROME; PEOPLE; INTERVENTION; MANAGEMENT; PSYCHOSIS; RISK;
   CARE
AB Objective: The objective of this study was to apply a quality improvement collaborative to increase the number of physical health assessments conducted with consumers diagnosed with schizophrenia in adult community mental health services across Queensland.
   Method: Sixteen adult mental health service organisations voluntarily took part in the statewide collaborative initiative to increase the number of physical health assessments completed on persons with a diagnosis of schizophrenia spectrum disorders managed through the community mental health service.
   Results: Improvement in the physical health assessment clinical indicator was demonstrated across the state over a 3-year period with an increase in the number of physical health assessments recorded from 12% to 58%.
   Conclusions: Significant improvements were made over a 3-year period by all mental health services involved in the collaborative, supporting the application of a quality improvement methodology to drive change across mental health services.
C1 [Plever, Sally; Emmerson, Brett] Metro North Hosp & Hlth Serv, Mental Hlth Clin Collaborat, Mental Hlth, Brisbane, Qld, Australia.
   [McCarthy, Irene; Anzolin, Melissa] Metro North Hosp & Hlth Serv, Mental Hlth Clin Collaborat, Mental Windsor, Brisbane, Qld, Australia.
   [Emmerson, Brett] Metro North Hosp & Hlth Serv, Mental Hlth, Brisbane, Qld, Australia.
   [Khatun, Mohsina] Univ Queensland, Sch Publ Hlth, Fac Med & Biomed Sci, Brisbane, Qld, Australia.
C3 University of Queensland
RP Plever, S (corresponding author), Metro North HHS, Mental Hlth Clin Collaborat, Bldg 14,Lawrence House, Brisbane, Qld, Australia.
EM Sally.Plever@health.qld.gov.au
RI Emmerson, William/M-1214-2015
OI Plever, Sally/0000-0002-0574-9163; Emmerson, William
   Brett/0009-0009-0833-6362
CR Barnes TRE, 2008, ACTA PSYCHIAT SCAND, V118, P26, DOI 10.1111/j.1600-0447.2008.01203.x
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   Plever S, 2010, AUSTRALAS PSYCHIATRY, V18, P106, DOI 10.3109/10398560903176933
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   Wilson E, 2014, AUSTRALAS PSYCHIATRY, V22, P248, DOI 10.1177/1039856214529000
NR 14
TC 2
Z9 2
U1 0
U2 4
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1039-8562
EI 1440-1665
J9 AUSTRALAS PSYCHIATRY
JI Australas. Psychiatry
PD FEB
PY 2016
VL 24
IS 1
BP 55
EP 61
DI 10.1177/1039856215608285
PG 7
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA DD1GO
UT WOS:000369669500013
PM 26432652
DA 2025-06-11
ER

PT J
AU Jialal, I
   Jialal, G
   Devaraj, S
   Adams-Huet, B
AF Jialal, Ishwarlal
   Jialal, Ganesh
   Devaraj, Sridevi
   Adams-Huet, Beverley
TI The effect of increasing tertiles of waist circumference on
   cardio-metabolic risk, adipokines and biomarkers of inflammation and
   oxidative stress in nascent metabolic syndrome
SO JOURNAL OF DIABETES AND ITS COMPLICATIONS
LA English
DT Article
DE Obesity; Inflammation; Waist circumference; Waist-height ratio;
   Adipokines; Body mass index
ID BODY-MASS INDEX; TO-HEIGHT RATIO; GROUP BOX PROTEIN-1;
   CARDIOVASCULAR-DISEASE; CARDIOMETABOLIC RISK; SCREENING TOOL; OBESITY;
   ASSOCIATION; STATEMENT; MORTALITY
AB Aims: The effect of waist circumference (WC) on cardio-metabolic features and biomarkers of oxidative stress and inflammation and adipose tissue dysregulation is poorly defined in Metabolic Syndrome (MetS). Hence the aim of this study was to examine the effect of increasing tertiles of WC on the cardio metabolic risk profile, pro-oxidant state, pro-inflammatory state and adipose tissue dysregulation in nascent MetS patients (n = 59) without diabetes or CVD.
   Methods and results: None of the main cardio-metabolic features including blood pressure, blood glucose, HDL-cholesterol, triglycerides, HOMA-IR, and free fatty acids increased with increasing WC tertiles except for hsCRP. In addition, none of the biomarkers of oxidative stress increased with increasing WC. Other circulating and cellular bio-mediators of inflammation and adipokines did not show significant increase with increasing WC. Using the waist to height ratio (WHtR) also did not reveal any major findings with increasing tertiles.
   Conclusion: In conclusion, in a well-defined cohort of MetS we failed to show any superiority of either WC or WHtR compared to BMI in capturing the cardio-metabolic cluster, adipose tissue dysregulation and the increased burden of oxidative stress and inflammation in this pilot study. These observations need confirmation in larger studies. (C) 2018 Elsevier Inc. All rights reserved.
C1 [Jialal, Ishwarlal; Jialal, Ganesh] Calif North State Univ, Coll Med, Sacramento, CA USA.
   [Devaraj, Sridevi] Baylor Coll Med, Houston, TX 77030 USA.
   [Adams-Huet, Beverley] Univ Texas Southwestern Med Ctr Dallas, Div Biostat, Dallas, TX 75390 USA.
C3 Baylor College of Medicine; University of Texas System; University of
   Texas Southwestern Medical Center Dallas
RP Jialal, I (corresponding author), Calif Northstate Univ, Coll Med, 9700 West Taron Dr, Elk Grove, CA 95757 USA.
EM ishwarlal.jialal@cnsu.edu
RI Jialal, Ishwarlal/AAG-6218-2019
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NR 25
TC 4
Z9 4
U1 0
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1056-8727
EI 1873-460X
J9 J DIABETES COMPLICAT
JI J. Diabetes Complications
PD APR
PY 2018
VL 32
IS 4
BP 379
EP 383
DI 10.1016/j.jdiacomp.2018.01.008
PG 5
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA GA5GP
UT WOS:000428361500006
PM 29478813
DA 2025-06-11
ER

PT J
AU Newson, L
   Abayomi, J
AF Newson, Lisa
   Abayomi, Julie
TI Reframing interventions for optimal child nutrition and childhood
   obesity: the importance of considering psychological factors
SO PROCEEDINGS OF THE NUTRITION SOCIETY
LA English
DT Review; Early Access
DE Childhood obesity; Nutrition; Psychosocial; Behaviour change;
   Interventions
ID BEHAVIOR-CHANGE TECHNIQUES; LIFE-STYLE; CARDIOMETABOLIC RISK; PEDIATRIC
   OBESITY; PHYSICAL-ACTIVITY; HYPOVITAMINOSIS-D; IRON-DEFICIENCY;
   MENTAL-HEALTH; VITAMIN-D; ADOLESCENTS
AB This review aims to emphasise the impact of poor nutrition on children's health and psychological well-being, urging those involved in childhood obesity or nutrition services to broaden their intervention approach. Poor nutrition and childhood obesity affect physical and psychological health. The stress of living with obesity further impacts quality of life, well-being and self-esteem. Children living with obesity may experience adverse childhood events and stress, and young people are able to recall the impact of psychosocial issues such as experiencing stigma and discrimination. Food is often a coping mechanism for managing negative emotions, perpetuating cycles of emotional coping and unhealthy eating behaviours. UK guidelines recommend family-based, multi-component weight management interventions for children living with obesity. Interventions mainly target health behaviours and utilise behaviour change techniques attempting to directly improve diet and physical activity as behavioural outcomes. Whilst these interventions may show some improvements in psychological well-being, there is limited consideration or understanding of the underlying mechanisms of action which indirectly influence engagement and the sustainability of the behaviour change. Lack of attention and inclusion of psychosocial variables in intervention implementation may help explain the variable effectiveness reported across childhood obesity interventions. In conclusion, enhancing the effectiveness of childhood obesity interventions requires a broader approach that fully incorporates psychosocial factors. Those responsible for commissioning, designing and implementing these interventions should adopt a holistic approach that addresses psychological and emotional needs while incorporating underlying mechanisms of action. This shift in focus could result in more sustainable and comprehensive treatment for childhood obesity.
C1 [Newson, Lisa] Liverpool John Moores Univ, Fac Hlth, Res Ctr Brain & Behav, Sch Psychol, Liverpool, England.
   [Newson, Lisa] Liverpool Ctr Cardiovasc Sci, Liverpool, England.
   [Abayomi, Julie] Edgehill Univ, Fac Hlth Social Care & Med, Liverpool, England.
C3 University of Liverpool; Liverpool John Moores University
RP Newson, L (corresponding author), Liverpool John Moores Univ, Fac Hlth, Res Ctr Brain & Behav, Sch Psychol, Liverpool, England.; Newson, L (corresponding author), Liverpool Ctr Cardiovasc Sci, Liverpool, England.
EM l.m.newson@ljmu.ac.uk
RI Newson, Lisa/AFV-0607-2022
OI Newson, Lisa/0000-0002-5874-8762; Abayomi, Julie/0000-0002-8133-5595
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NR 100
TC 7
Z9 7
U1 7
U2 23
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0029-6651
EI 1475-2719
J9 P NUTR SOC
JI Proc. Nutr. Soc.
PD 2024 JAN 11
PY 2024
DI 10.1017/S0029665124000028
EA JAN 2024
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA GM4I2
UT WOS:001153067100001
PM 38205619
OA Green Submitted, Green Accepted, hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Brunner, EJ
AF Brunner, Eric John
TI Social factors and cardiovascular morbidity
SO NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
LA English
DT Review
ID CORONARY-HEART-DISEASE; JOB STRAIN; HEALTH BEHAVIORS; SOCIOECONOMIC
   POSITION; METABOLIC SYNDROME; DECISION LATITUDE; CENTRAL OBESITY;
   WHITEHALL; STRESS; RISK
AB Recent progress in population health at aggregate level, measured by life expectancy, has been accompanied by lack of progress in reducing the difference in health prospects between groups defined by social status. Cardiovascular disease is an important contributor to this undesirable situation. The stepwise gradient of higher risk with lower status is accounted for partly by social gradients in health behaviors. The psychosocial hypothesis provides a stronger explanation, based on social patterning of living and working environments and psychological assets that individuals develop during childhood. Three decades of research based on Whitehall II and other cohort studies provide evidence for psychosocial pathways leading to cardiovascular morbidity and mortality. Job stress is a useful paradigm because exposure is long term and depends on occupational status. Studies of social-biological translation implicate autonomic and neuroendocrine function among the biological systems that mediate between chronic adverse psychosocial exposures and increased cardiometabolic risk and cardiovascular disease incidence. (C) 2016 Elsevier Ltd. All rights reserved.
C1 [Brunner, Eric John] UCL, Dept Epidemiol & Publ Hlth, London, England.
C3 University of London; University College London
RP Brunner, EJ (corresponding author), UCL, Dept Epidemiol & Publ Hlth, London, England.
EM e.brunner@ucl.ac.uk
RI Brunner, Eric/H-2114-2011
OI Brunner, Eric/0000-0002-0595-4474
FU British Heart Foundation [RG/13/2/30098]; British Medical Research
   Council [K013351]; US National Heart, Lung, and Blood Institute
   [R01HL036310]; US National Institute on Aging [R01AG013196]; European
   Commission [613598]; ESRC [ES/J023299/1] Funding Source: UKRI; MRC
   [MR/K013351/1] Funding Source: UKRI
FX The author's research is supported by British Heart Foundation
   (RG/13/2/30098), British Medical Research Council (K013351), US National
   Heart, Lung, and Blood Institute (R01HL036310), US National Institute on
   Aging (R01AG013196) and European Commission Framework 7 Moodfood
   Collaborative Project (613598).
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NR 44
TC 27
Z9 30
U1 1
U2 15
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0149-7634
EI 1873-7528
J9 NEUROSCI BIOBEHAV R
JI Neurosci. Biobehav. Rev.
PD MAR
PY 2017
VL 74
SI SI
BP 260
EP 268
DI 10.1016/j.neubiorev.2016.05.004
PN B
PG 9
WC Behavioral Sciences; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Behavioral Sciences; Neurosciences & Neurology
GA EM9AF
UT WOS:000395602500002
PM 27177828
OA Green Accepted, Green Submitted
DA 2025-06-11
ER

PT J
AU Feldman, F
   Koudoufio, M
   El-Jalbout, R
   Sauvé, MF
   Ahmarani, L
   Sané, AT
   Ould-Chikh, NE
   N'Timbane, T
   Patey, N
   Desjardins, Y
   Stintzi, A
   Spahis, S
   Levy, E
AF Feldman, Francis
   Koudoufio, Mireille
   El-Jalbout, Ramy
   Sauve, Mathilde Foisy
   Ahmarani, Lena
   Sane, Alain Theophile
   Ould-Chikh, Nour-El-Houda
   N'Timbane, Thierry
   Patey, Natalie
   Desjardins, Yves
   Stintzi, Alain
   Spahis, Schohraya
   Levy, Emile
TI Cranberry Proanthocyanidins as a Therapeutic Strategy to Curb Metabolic
   Syndrome and Fatty Liver-Associated Disorders
SO ANTIOXIDANTS
LA English
DT Article
DE proanthocyanidins; metabolic syndrome; insulin resistance;
   hyperlipidemia; oxidative stress; inflammation
ID APPLE PEEL POLYPHENOLS; INSULIN-RESISTANCE; NONALCOHOLIC
   STEATOHEPATITIS; MITOCHONDRIAL DYSFUNCTION; CARDIOMETABOLIC RISK;
   HEPATIC STEATOSIS; ADIPOSE-TISSUE; GLUCOSE; MECHANISMS; EXTRACT
AB While the prevalence of metabolic syndrome (MetS) is steadily increasing worldwide, no optimal pharmacotherapy is readily available to address its multifaceted risk factors and halt its complications. This growing challenge mandates the development of other future curative directions. The purpose of the present study is to investigate the efficacy of cranberry proanthocyanidins (PACs) in improving MetS pathological conditions and liver complications; C57BL/6J mice were fed either a standard chow or a high fat/high sucrose (HFHS) diet with and without PACs (200 mg/kg), delivered by daily gavage for 12 weeks. Our results show that PACs lowered HFHS-induced obesity, insulin resistance, and hyperlipidemia. In conjunction, PACs lessened circulatory markers of oxidative stress (OxS) and inflammation. Similarly, the anti-oxidative and anti-inflammatory capacities of PACs were noted in the liver in association with improved hepatic steatosis. Inhibition of lipogenesis and stimulation of beta-oxidation could account for PACs-mediated decline of fatty liver as evidenced not only by the expression of rate-limiting enzymes but also by the status of AMPK alpha (the key sensor of cellular energy) and the powerful transcription factors (PPAR alpha, PGC1 alpha, SREBP1c, ChREBP). Likewise, treatment with PACs resulted in the downregulation of critical enzymes of liver gluconeogenesis, a process contributing to increased rates of glucose production in type 2 diabetes. Our findings demonstrate that PACs prevented obesity and improved insulin resistance likely via suppression of OxS and inflammation while diminishing hyperlipidemia and fatty liver disease, as clear evidence for their strength of fighting the cluster of MetS abnormalities.
C1 [Feldman, Francis; Koudoufio, Mireille; El-Jalbout, Ramy; Sauve, Mathilde Foisy; Ahmarani, Lena; Sane, Alain Theophile; Ould-Chikh, Nour-El-Houda; N'Timbane, Thierry; Patey, Natalie; Spahis, Schohraya; Levy, Emile] Sainte Justine Univ, Res Ctr, Hlth Ctr, Montreal, PQ H3T 1C5, Canada.
   [Feldman, Francis; Koudoufio, Mireille; Sauve, Mathilde Foisy; Levy, Emile] Univ Montreal, Dept Nutr, Montreal, PQ H3T 1J4, Canada.
   [El-Jalbout, Ramy] Univ Montreal, Dept Radiol, Montreal, PQ H3T 1J4, Canada.
   [Patey, Natalie] Univ Montreal, Dept Pathol, Montreal, PQ H3T 1J4, Canada.
   [Desjardins, Yves] Laval Univ, Inst Nutr & Funct Foods, Quebec City, PQ G1V 4L3, Canada.
   [Stintzi, Alain] Univ Ottawa, Ottawa Inst Syst Biol, Fac Med, Dept Biochem Microbiol & Immunol, Ottawa, ON K1H 8M5, Canada.
   [Spahis, Schohraya] Univ Montreal, Dept Biochem & Mol Med, Montreal, PQ H3T 1J4, Canada.
C3 Universite de Montreal; Universite de Montreal; Universite de Montreal;
   Laval University; University of Ottawa; Universite de Montreal
RP Levy, E (corresponding author), Sainte Justine Univ, Res Ctr, Hlth Ctr, Montreal, PQ H3T 1C5, Canada.; Levy, E (corresponding author), Univ Montreal, Dept Nutr, Montreal, PQ H3T 1J4, Canada.
EM emile.levy.hsj@ssss.gouv.qc.ca
RI Jalbout, Ramy/AAT-6880-2020; Desjardins, Yves/F-1222-2013
OI Levy, Emile/0000-0001-9983-7027; Desjardins, Yves/0000-0002-0398-2797;
   Spahis, Schohraya/0000-0003-4130-4994; Feldman,
   Francis/0000-0003-2758-9305; Sane, Alain Theophile/0000-0001-6567-1153
FU J.A. DeSeve Research Chair in Nutrition; Ontario Genomics
   Institute/Genome Canada [E8377]; NSERC-Diana Food Industrial Chair on
   prebiotic effects of polyphenols [401240871]
FX This study was supported by the J.A. DeSeve Research Chair in Nutrition
   (E.L.), the Ontario Genomics Institute/Genome Canada/E8377 (E.L. & A.S.)
   and NSERC-Diana Food Industrial Chair on prebiotic effects of
   polyphenols (401240871) (E.L. & Y.D.)
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NR 68
TC 9
Z9 9
U1 1
U2 26
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD JAN
PY 2023
VL 12
IS 1
AR 90
DI 10.3390/antiox12010090
PG 17
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA 8A9KE
UT WOS:000916551300001
PM 36670951
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Aparicio, E
   Canals, J
   Voltas, N
   Hernández-Martínez, C
   Arija, V
AF Aparicio, Estefania
   Canals, Josefa
   Voltas, Nuria
   Hernandez-Martinez, Carmen
   Arija, Victoria
TI Emotional psychopathology and increased adiposity: Follow-up study in
   adolescents
SO JOURNAL OF ADOLESCENCE
LA English
DT Article
DE Depression; Anxiety; Weight gain; Waist circumference; Longitudinal
   study
ID INTERNATIONAL NEUROPSYCHIATRIC INTERVIEW; BODY-MASS INDEX; ANXIETY
   DISORDERS; DEPRESSIVE SYMPTOMS; METABOLIC SYNDROME; CHILDHOOD OBESITY;
   DSM-IV; CHILDREN; ASSOCIATION; COMORBIDITY
AB Based on data from a three-year longitudinal study, we assess the effect, according to gender, of emotional psychopathology in preadolescence on anthropometric and body composition parameters in adolescence (N = 229). Psychopathology was assessed using the Screen for Childhood Anxiety and Related Emotional Disorders, the Children's Depression Inventory and the MINI-International Neuropsychiatric Interview for Kids. Body fat percentage (%BF), waist circumference (WC) and body mass index (BMI) were also determined. Following analysis with adjusted multiple regression models, the results indicated that symptoms of depression and separation anxiety were significantly associated with increased WC and BMI in boys, and that somatic symptoms were associated with increased WC and %BF in girls. Diagnosis of social phobia, panic disorder or dysthymia led to significantly increased WC and/or BMI in boys and dysthymia increased WC in girls. These findings suggest that emotional psychopathology in preadolescence is associated with increased weight gain and abdominal fat in adolescence. (C) 2012 The Foundation for Professionals in Services for Adolescents. Published by Elsevier Ltd. All rights reserved.
C1 [Aparicio, Estefania; Arija, Victoria] Univ Rovira & Virgili, Nutr & Mental Hlth Res Grp NUTRISAM, Fac Med & Hlth Sci, E-43201 Reus, Spain.
   [Canals, Josefa] Univ Rovira & Virgili, Nutr & Mental Hlth Res Grp NUTRISAM, Fac Educ Sci & Psychol, Tarragona 43201, Spain.
   [Canals, Josefa; Voltas, Nuria; Hernandez-Martinez, Carmen] Univ Rovira & Virgili, Dept Psychol, CRAMC, Res Ctr Behav Assessment, Tarragona 43201, Spain.
   [Canals, Josefa; Hernandez-Martinez, Carmen; Arija, Victoria] URV, IISPV, Catalonia, Spain.
   [Arija, Victoria] IDIAP Jordi Gol & Gurina, Inst Invest Atencio Primaria, Catalonia, Spain.
C3 Universitat Rovira i Virgili; Universitat Rovira i Virgili; Universitat
   Rovira i Virgili; Universitat Rovira i Virgili; Institut d'Investigacio
   Sanitaria Pere Virgili (IISPV)
RP Arija, V (corresponding author), Univ Rovira & Virgili, Publ Heath & Nutr Unit, Fac Med & Hlth Sci, C San Llorenc 21, Tarragona 43201, Spain.
EM victoria.arija@urv.cat
RI Canals, Josefa/H-7551-2015; Aparicio, Estefania/AAA-8182-2020;
   Hernandez-Martinez, Carmen/H-6019-2015; Voltas, Nuria/H-8122-2015
OI Aparicio, Estefania/0000-0003-0542-0015; Arija,
   Victoria/0000-0002-1758-0975; Hernandez-Martinez,
   Carmen/0000-0001-6328-8679; Voltas, Nuria/0000-0001-8855-0282
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NR 63
TC 17
Z9 20
U1 1
U2 27
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 0140-1971
EI 1095-9254
J9 J ADOLESCENCE
JI J. Adolesc.
PD APR
PY 2013
VL 36
IS 2
BP 319
EP 330
DI 10.1016/j.adolescence.2012.12.003
PG 12
WC Psychology, Developmental
WE Social Science Citation Index (SSCI)
SC Psychology
GA 126RL
UT WOS:000317638800008
PM 23434271
DA 2025-06-11
ER

PT J
AU Reser, JE
   Reser, WW
AF Reser, Jared E.
   Reser, William W.
TI Does rheumatoid arthritis represent an adaptive, thrifty condition?
SO MEDICAL HYPOTHESES
LA English
DT Article
ID ADRENAL STRESS AXIS; DIABETES-MELLITUS; RISK-FACTORS; EVOLUTION;
   PREVALENCE; DEPRESSION; PREGNANCY; INDIANS; PAIN
AB The present article presents epidemiological, and comparative evidence Supporting the hypothesis that rheumatoid arthritis (RA) may represent a thrifty adaptation selected to compel animals to minimize voluntary energy expenditure. The autoimmune, pathophysiological manifestations underlying RA are framed here as constituting an evolved, protective mechanism that would have influenced animals to avoid exertion and maintain a sedentary lifestyle in order to minimize metabolic output and ultimately escape starvation. Arthritic pain is characterized here as a defensive, innate signal much like fatigue, fever, nausea and reflexive pain, and like these, is seen on a continuum varying between imperceptible encumbrance and debilitating disability. The epigenetic relationship between acute psychological stress and flare-up of arthritic symptoms is examined and taken to suggest that arthritis may be a predictive, adaptive response to severe stress allowing reductions in metabolism to follow adverse conditions or nutritional scarcity. The close associations between rheumatoid arthritis and the metabolic syndrome are also explored along with potential ties to the "thrifty genotype" and "thrifty phenotype" phenomena. This hypothesis is examined in the contexts of evolutionary medicine, phenotypic plasticity, the stress response and the bioenergetics of thrift. A brief and exploratory review of pertinent evidence suggests that RA, its subclinical manifestations, and even other forms of arthropathy may possibly represent adaptations that promoted metabolic thrift during our evolutionary past. (C) 2009 Elsevier Ltd. All rights reserved.
C1 [Reser, Jared E.] Univ So Calif, Encino, CA 91436 USA.
   [Reser, William W.] Univ Calif Davis, Davis, CA 95616 USA.
C3 University of Southern California; University of California System;
   University of California Davis
RP Reser, JE (corresponding author), Univ So Calif, 16380 Meadow Ridge Rd, Encino, CA 91436 USA.
EM jared@jaredreser.com; williamwreser@sbcglobal.net
OI Reser, Jared/0000-0003-0580-3403
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NR 52
TC 3
Z9 3
U1 0
U2 12
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0306-9877
EI 1532-2777
J9 MED HYPOTHESES
JI Med. Hypotheses
PD JAN
PY 2010
VL 74
IS 1
BP 189
EP 194
DI 10.1016/j.mehy.2009.07.041
PG 6
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Research & Experimental Medicine
GA 547VU
UT WOS:000273918500054
PM 19716239
DA 2025-06-11
ER

PT J
AU Gonzalez-Chica, DA
   Bowden, J
   Miller, C
   Longo, M
   Nelson, M
   Reid, C
   Stocks, N
AF Gonzalez-Chica, David Alejandro
   Bowden, Jacqueline
   Miller, Caroline
   Longo, Marie
   Nelson, Mark
   Reid, Christopher
   Stocks, Nigel
TI Patient-reported GP health assessments rather than individual
   cardiovascular risk burden are associated with the engagement in
   lifestyle changes: population-based survey in South Australia
SO BMC FAMILY PRACTICE
LA English
DT Article
DE Cardiovascular disease; Primary prevention; Secondary prevention;
   Lifestyle risk reduction
ID QUALITY-OF-LIFE; GENERAL-PRACTITIONERS; NUTRITION CARE; DISEASE;
   MANAGEMENT; OBESITY; ADULTS; GAPS
AB Background Little is known about whether a more comprehensive health assessment, performed by a general practitioner (GP) during a clinical encounter, could influence patients' lifestyle. We aimed to investigate whether health assessments, performed by GPs, are more important than the presence of cardiovascular disease (CVD) or cardiometabolic risk factors (obesity, diabetes, hypertension, dyslipidaemia) for engagement in lifestyle change. Methods Cross-sectional, population-based survey conducted in South Australia (September-December 2017) using face-to-face interviews and self-reported data of 2977 individuals aged 15+ years. The main outcome was engagement in four lifestyle changes: 1) increasing fruit/vegetable intake, 2) increasing physical activity level, 3) reducing alcohol consumption, and 4) attempts to stop smoking. Health assessments performed by a GP in the last 12 months included clinical/laboratory investigations (weight/waist circumference, blood pressure, glucose levels, lipid levels) and questions about lifestyle/wellbeing (current diet, physical activity, smoking status, alcohol intake, mental health, sleeping problems). Results were restricted to individuals aged 35+ years because of the low prevalence of CVD or their risk factors among younger participants. Logistic regression was used in all associations, adjusted for sociodemographic, lifestyle, mental health, and clinical variables. Results Of the 2384 investigated adults (mean age 57.3 +/- 13.9 years; 51.9% females), 10.2% had CVD and 49.1% at least one cardiometabolic risk factor. Clinical/laboratory assessments performed by the GP were 2-3 times more frequent than assessments of lifestyle, mental health status, or sleeping problems, especially among those with CVD. Individuals with CVD or a cardiometabolic risk factor were no more likely to be increasing their fruit/vegetable consumption (33.6%), physical activity level (40.9%), reducing alcohol consumption (31.1%), or trying to quit smoking (34.0%) than 'healthy' participants. However, lifestyle changes were between 30 and 100% more likely when GPs performed three or more health assessments (either clinical/laboratory or questions about lifestyle/wellbeing) than when individuals did not visit the GP or when GPs performed no any assessment during these clinical encounters (p < 0.05 in all cases). Conclusion More frequent and comprehensive CVD-related assessments by GPs were more important in promoting a healthier lifestyle than the presence of CVD or cardiometabolic risk factors by themselves.
C1 [Gonzalez-Chica, David Alejandro; Stocks, Nigel] Univ Adelaide, Adelaide Med Sch, Discipline Gen Practice, Helen Mayo North,Sturt Rd,Level 1,Room 113, Adelaide, SA 5005, Australia.
   [Gonzalez-Chica, David Alejandro] Univ Adelaide, Adelaide Rural Clin Sch, Adelaide, SA, Australia.
   [Bowden, Jacqueline] South Australian Hlth & Med Res Inst, Populat Hlth Res Grp, Adelaide, SA, Australia.
   [Miller, Caroline; Longo, Marie] Drug & Alcohol Serv South Australia, Drug Policy & Populat Hlth, Populat Hlth & Clin Monitoring, Adelaide, SA, Australia.
   [Nelson, Mark] Univ Tasmania, Menzies Inst Med Res, Hobart, Tas, Australia.
   [Reid, Christopher] Curtin Univ, Sch Publ Hlth, Perth, WA, Australia.
C3 University of Adelaide; University of Adelaide; South Australian Health
   & Medical Research Institute (SAHMRI); University of Tasmania; Menzies
   Institute for Medical Research; Curtin University
RP Gonzalez-Chica, DA (corresponding author), Univ Adelaide, Adelaide Med Sch, Discipline Gen Practice, Helen Mayo North,Sturt Rd,Level 1,Room 113, Adelaide, SA 5005, Australia.; Gonzalez-Chica, DA (corresponding author), Univ Adelaide, Adelaide Rural Clin Sch, Adelaide, SA, Australia.
EM david.gonzalez@adelaide.edu.au
RI Gonzalez-Chica, David/L-5316-2019; Reid, Christopher/AAP-8135-2021;
   Stocks, Nigel/I-1083-2012; Miller, Caroline/X-2383-2019
OI Bowden, Jacqueline/0000-0003-1983-8930; Reid,
   Christopher/0000-0001-9173-3944; Miller, Caroline/0000-0001-9723-8047
FU Drug AMP; Alcohol Services South Australia (DASSA); Cancer Council SA
   (Research AMP; Evaluation Unit)
FX The author acknowledges the participants of the 2017 Spring Health
   Omnibus Survey for their participation in this study and Drug & Alcohol
   Services South Australia (DASSA) and Cancer Council SA (Research &
   Evaluation Unit) for their support in the development of this study.
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NR 34
TC 6
Z9 6
U1 0
U2 3
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2296
J9 BMC FAM PRACT
JI BMC Fam. Pract.
PD DEC 13
PY 2019
VL 20
IS 1
AR 173
DI 10.1186/s12875-019-1066-9
PG 10
WC Primary Health Care; Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA KK2YD
UT WOS:000512612800001
PM 31836016
OA Green Published, Green Accepted, gold
DA 2025-06-11
ER

PT J
AU Gawlik-Kotelnicka, O
   Strzelecki, D
AF Gawlik-Kotelnicka, Oliwia
   Strzelecki, Dominik
TI Adiposity in Depression or Depression in Adiposity? The Role of
   Immune-Inflammatory-Microbial Overlap
SO LIFE-BASEL
LA English
DT Review
DE depression; metabolic syndrome; non-alcoholic fatty liver disease;
   hypothalamic-pituitary-adrenal axis; inflammation; oxidative stress;
   microbiota
AB Some of the most common and debilitating conditions are metabolic disorders (metabolic syndrome and non-alcoholic fatty liver disease) and depression. These conditions are also exacerbated by the fact that they often co-occur. Although the exact mechanisms underlying such relationships are poorly known, antipsychotic medication and antidepressant use, diet and physical activity, and lifestyle factors are believed to play a role; however, their high co-occurrence rate suggests a possible pathophysiological overlap. This paper reviews several possible bases for this overlap, including hypothalamic-pituitary-adrenal axis dysregulation, immune alterations with chronic inflammation, and oxidative stress. While it is entirely possible that changes in the microbiota may play a role in each of them, interventions based on the implementation of dietary and other lifestyle changes, supplementation with prebiotics or probiotics and faecal microbiota transplantation have failed to achieve conclusive results. A better characterization of the above associations may allow a more targeted approach to the treatment of both depressive and metabolic disorders. The paper also presents several practical applications for future studies.
C1 [Gawlik-Kotelnicka, Oliwia; Strzelecki, Dominik] Med Univ Lodz, Dept Affect & Psychot Disorders, Czechoslowacka St 8-10, PL-92216 Lodz, Poland.
C3 Medical University Lodz
RP Gawlik-Kotelnicka, O (corresponding author), Med Univ Lodz, Dept Affect & Psychot Disorders, Czechoslowacka St 8-10, PL-92216 Lodz, Poland.
EM oliwia.gawlik@umed.lodz.pl; dominik.strzelecki@umed.lodz.pl
RI Strzelecki, Dominik/S-9340-2016; Gawlik-Kotelnicka,
   Oliwia/ITU-7979-2023; Gawlik-Kotelnicka, Oliwia/S-9936-2016
OI Gawlik-Kotelnicka, Oliwia/0000-0003-1398-3117; Strzelecki,
   Dominik/0000-0002-8559-1078
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NR 112
TC 14
Z9 14
U1 0
U2 8
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2075-1729
J9 LIFE-BASEL
JI Life-Basel
PD FEB
PY 2021
VL 11
IS 2
AR 117
DI 10.3390/life11020117
PG 11
WC Biology; Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Life Sciences & Biomedicine - Other Topics; Microbiology
GA QN8KH
UT WOS:000622700600001
PM 33557031
OA gold, Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Hwang, IW
   Hwang, SJ
   Shen, JH
   Kim, J
   Lee, JM
AF Hwang, In-Whi
   Hwang, Soo-Ji
   Shen, Jun-Hao
   Kim, Jisu
   Lee, Jung-Min
TI How Does the Weekend Catch-Up Sleep Ratio Affect the Health and
   Lifestyle of Korean Adults? An Age- and Sex-Matched Study
SO MEASUREMENT IN PHYSICAL EDUCATION AND EXERCISE SCIENCE
LA English
DT Article; Early Access
DE Sleep patterns; physical activity; sedentary behavior; mental health;
   cardiometabolic risk factors
ID PHYSICAL-ACTIVITY; SEDENTARY BEHAVIOR; NATIONAL-HEALTH; MENTAL-HEALTH;
   SHIFT WORK; DURATION; QUALITY; RISK; ASSOCIATION; IMPACT
AB This study examined the impact of Catch-Up Sleep Ratio (CSR) on health outcomes in Korean adults. Adjusted for age and gender, 2,484 participants were categorized into three groups: Weekday (CSR <1.0), Average (1.0 <= CSR < 1.5), and Weekend (1.5 <= CSR). Weekday participants were less likely to meet WHO's moderate physical activity guidelines (OR = 0.79, p < .05), walk 4-6 days per week (OR = 0.70, p < .05), or engage in prolonged sedentary behavior (OR = 0.60, p < .001). The Weekend group exhibited higher odds of obesity (OR = 1.96, p < .01), increased stress (OR = 1.78, p < .001), and perceived themselves as more obese (OR = 1.32, p < .01) while showing lower rates of low HDL cholesterol (OR = 0.66, p < .01). These findings suggest that CSR could significantly impact health behaviors and outcomes.
C1 [Hwang, In-Whi] Kyung Hee Univ, Grad Sch Phys Educ, Dept Sports Med & Sci, Yongin, South Korea.
   [Hwang, Soo-Ji; Shen, Jun-Hao] Kyung Hee Univ, Grad Sch Phys Educ, Dept Phys Educ, Yongin, South Korea.
   [Kim, Jisu] Virginia Commonwealth Univ, Dept Kinesiol & Hlth Sci, Richmond, VA USA.
   [Lee, Jung-Min] Kyung Hee Univ, Sports Sci Res Ctr, Global Campus, Yongin, South Korea.
   [Lee, Jung-Min] Kyung Hee Univ, Dept Phys Educ, Yongin, South Korea.
C3 Kyung Hee University; Kyung Hee University; Virginia Commonwealth
   University; Kyung Hee University; Kyung Hee University
RP Lee, JM (corresponding author), Kyung Hee Univ, Sports Sci Res Ctr, Global Campus, Yongin, South Korea.; Lee, JM (corresponding author), Kyung Hee Univ, Dept Phys Educ, Yongin, South Korea.
EM jungminlee@khu.ac.kr
RI Lee, Jung-Min/L-8227-2016
FU Kyung Hee University [KHU-20220924]
FX This work was supported by a grant from Kyung Hee University in 2022
   [KHU-20220924].
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NR 55
TC 0
Z9 0
U1 0
U2 0
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 1091-367X
EI 1532-7841
J9 MEAS PHYS EDUC EXERC
JI Meas. Phys. Educ. Exerc. Sci.
PD 2025 FEB 6
PY 2025
DI 10.1080/1091367X.2025.2460758
EA FEB 2025
PG 12
WC Education & Educational Research; Hospitality, Leisure, Sport & Tourism;
   Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Education & Educational Research; Social Sciences - Other Topics; Sport
   Sciences
GA U8Q9N
UT WOS:001414383300001
DA 2025-06-11
ER

PT J
AU Bremer, AA
   Mietus-Snyder, M
   Lustig, RH
AF Bremer, Andrew A.
   Mietus-Snyder, Michele
   Lustig, Robert H.
TI Toward a Unifying Hypothesis of Metabolic Syndrome
SO PEDIATRICS
LA English
DT Review
DE metabolic syndrome; insulin resistance; dyslipidemia; hypertension;
   diabetes; pediatrics
ID FATTY LIVER-DISEASE; ENDOPLASMIC-RETICULUM STRESS; FRUCTOSE CORN SYRUP;
   CARNITINE PALMITOYLTRANSFERASE SYSTEM; GLUCOSE-SWEETENED BEVERAGES;
   SUBCUTANEOUS ADIPOSE-TISSUE; INSULIN-RESISTANCE SYNDROME; ACTIVATED
   PROTEIN-KINASE; TYPE-2 DIABETES-MELLITUS; CORONARY-HEART-DISEASE
AB Despite a lack of consistent diagnostic criteria, the metabolic syndrome (MetS) is increasingly evident in children and adolescents, portending a tsunami of chronic disease and mortality as this generation ages. The diagnostic criteria for MetS apply absolute cutoffs to continuous variables and fail to take into account aging, pubertal changes, and race/ethnicity. We attempt to define MetS mechanistically to determine its specific etiologies and to identify targets for therapy. Whereas the majority of studies document a relationship of visceral fat to insulin resistance, ectopic liver fat correlates better with dysfunctional insulin dynamics from which the rest of MetS derives. In contrast to the systemic metabolism of glucose, the liver is the primary metabolic clearinghouse for 4 specific foodstuffs that have been associated with the development of MetS: trans-fats, branched-chain amino acids, ethanol, and fructose. These 4 substrates (1) are not insulin regulated and (2) deliver metabolic intermediates to hepatic mitochondria without an appropriate "pop-off" mechanism for excess substrate, enhancing lipogenesis and ectopic adipose storage. Excessive fatty acid derivatives interfere with hepatic insulin signal transduction. Reactive oxygen species accumulate, which cannot be quenched by adjacent peroxisomes; these reactive oxygen species reach the endoplasmic reticulum, leading to a compensatory process termed the "unfolded protein response," driving further insulin resistance and eventually insulin deficiency. No obvious drug target exists in this pathway; thus, the only rational therapeutic approaches remain (1) altering hepatic substrate availability (dietary modification), (2) reducing hepatic substrate flux (high fiber), or (3) increasing mitochondrial efficiency (exercise). Pediatrics 2012; 129:557-570
C1 [Lustig, Robert H.] Univ Calif San Francisco, Dept Pediat, San Francisco, CA 94143 USA.
   [Bremer, Andrew A.] Vanderbilt Univ, Sch Med, Dept Pediat, Nashville, TN 37212 USA.
   [Mietus-Snyder, Michele] Childrens Natl Med Ctr, Dept Pediat, Washington, DC 20010 USA.
   [Mietus-Snyder, Michele] Childrens Natl Med Ctr, Childrens Natl Obes Inst, Washington, DC 20010 USA.
C3 University of California System; University of California San Francisco;
   Vanderbilt University; Children's National Health System; Children's
   National Health System
RP Lustig, RH (corresponding author), Univ Calif San Francisco, Dept Pediat, Suite S679,Box 0434,513 Parnassus Ave, San Francisco, CA 94143 USA.
EM rlustig@peds.ucsf.edu
RI Lustig, Robert/O-9380-2019
OI Mietus-Snyder, Michele/0000-0003-2791-9896
FU National Institutes of Health (NIH)
FX Funded by the National Institutes of Health (NIH).
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NR 176
TC 133
Z9 151
U1 1
U2 42
PU AMER ACAD PEDIATRICS
PI ELK GROVE VILLAGE
PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA
SN 0031-4005
EI 1098-4275
J9 PEDIATRICS
JI Pediatrics
PD MAR
PY 2012
VL 129
IS 3
BP 557
EP 570
DI 10.1542/peds.2011-2912
PG 14
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA 922IQ
UT WOS:000302541000055
PM 22351884
OA Green Published
DA 2025-06-11
ER

PT J
AU Berthold, SM
   Bermudez-Millan, A
   Buckley, T
   Buxton, OM
   Feinn, R
   Kong, S
   Kuoch, T
   Scully, M
   Seng, K
   Wagner, J
AF Berthold, S. Megan
   Bermudez-Millan, Angela
   Buckley, Thomas
   Buxton, Orfeu M.
   Feinn, Richard
   Kong, Sengly
   Kuoch, Theanvy
   Scully, Mary
   Seng, Kagnica
   Wagner, Julie
TI Social disconnection and metabolic syndrome score among Cambodian
   Americans with depression
SO DIABETES RESEARCH AND CLINICAL PRACTICE
LA English
DT Article
DE Metabolic syndrome; Social alienation; Social support; Depression;
   Cambodian; Diabetes
ID PATIENT-REPORTED OUTCOMES; ALIENATION; HEALTH; ACCULTURATION; IMMIGRANT;
   MORTALITY; SUPPORT; STRESS; ASSOCIATION; LONELINESS
AB Aims: Migrants experience social disconnection and also have high risk for metabolic syndrome (MetS). This study explored associations of social alienation, social isolation, and social support with MetS among Cambodian Americans.
   Methods: We conducted secondary data analysis on baseline assessments from a diabetes prevention trial for Cambodian Americans with depression and high risk for diabetes. Participants were aged 35-75, Cambodian or Cambodian-American, Khmer speaking, lived in Cambodia during the Pol Pot regime, lived in the northeastern U.S. at the time of study, endorsed elevated risk factors for diabetes and met criteria for depression by medication for depression and/or elevated depressive symptoms. They completed surveys and provided anthropometric and blood pressure measurements and fasting blood samples.
   Results: In multiple linear regressions, greater social alienation was associated with increased risk for MetS. The social alienation-MetS association was stronger in men than women. Associations were not better accounted for by crude indicators of social isolation such as marital status, living alone, and number of people in the household. Social support was not associated with MetS and did not buffer the deleterious association between social alienation and MetS.
   Conclusions: Decreasing social alienation may mitigate risk for MetS among migrant populations. (C) 2021 Elsevier B.V. All rights reserved.
C1 [Berthold, S. Megan] Univ Connecticut, Sch Social Work, Storrs, CT USA.
   [Bermudez-Millan, Angela] Univ Connecticut, Sch Med, Farmington, CT USA.
   [Buckley, Thomas] Univ Connecticut, Sch Pharm, Storrs, CT USA.
   [Buxton, Orfeu M.] Penn State Univ, State Coll, PA USA.
   [Feinn, Richard] Quinnipiac Univ, Hamden, CT 06518 USA.
   [Kong, Sengly; Kuoch, Theanvy; Scully, Mary] Khmer Hlth Advocates, Hartford, CT USA.
   [Seng, Kagnica] Cent Connecticut State Univ, New Britain, CT 06050 USA.
   [Wagner, Julie] UConn Hlth, Behav Sci & Community Hlth, Farmington, CT USA.
C3 University of Connecticut; University of Connecticut; University of
   Connecticut; Pennsylvania Commonwealth System of Higher Education
   (PCSHE); Pennsylvania State University; Pennsylvania State University -
   University Park; Quinnipiac University; Connecticut State University
   System; Central Connecticut State University
RP Wagner, J (corresponding author), UConn Hlth, 263 Farmington Ave, Farmington, CT 06030 USA.
EM juwagner@uchc.edu
RI Bermudez-Millan, Angela/HJP-0488-2023
OI Buxton, Orfeu/0000-0001-5057-633X
FU National Institutes of Diabetes, Digestive, and Kidney Diseases
   [DK103663]; National Institute on Aging [R44AG056250] Funding Source:
   NIH RePORTER
FX Funded by National Institutes of Diabetes, Digestive, and Kidney
   Diseases. DK103663.
CR American Diabetes Association, ARE YOU AR RISK DIAB
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NR 45
TC 2
Z9 2
U1 0
U2 8
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0168-8227
EI 1872-8227
J9 DIABETES RES CLIN PR
JI Diabetes Res. Clin. Pract.
PD MAY
PY 2021
VL 175
AR 108792
DI 10.1016/j.diabres.2021.108792
EA MAY 2021
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism
GA TF0BI
UT WOS:000670372100027
PM 33872632
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Siskind, D
   Yen, W
   Thuzar, M
   Russell, A
   Warren, N
   Kisely, S
   Ray, MK
   Motamarri, B
AF Siskind, Dan
   Yen, Wesley
   Thuzar, Moe
   Russell, Anthony
   Warren, Nicola
   Kisely, Steve
   Ray, Manaan Kar
   Motamarri, Balaji
TI Outcomes of a co-located approach for metabolic health care for people
   with schizophrenia
SO AUSTRALASIAN PSYCHIATRY
LA English
DT Article
DE metabolic syndrome; dyslipidaemia; schizophrenia; mental health;
   co-location
AB Objective Metabolic syndrome is highly prevalent among people with schizophrenia. This study aims to assess the impact on metabolic and attendance outcomes of a co-located, dedicated, endocrinologist-led metabolic clinic in a stand-alone public community mental health service. Methods Demographic and metabolic data on the first 48 consecutive referrals over a 12-month period were retrospectively collected and analysed. Attendance rates at the co-located clinic were compared to the general hospital obesity and diabetes clinics. Results Clinic attendees had significant reductions in triglycerides and total cholesterol, but not mean weight, BMI, waist circumference, blood pressure or HbA1c. Attendance rates were significantly higher in the co-located clinic compared to the general hospital obesity and diabetes clinics for both initial consult (80.0% vs 51.2%, p < 0.001) and review appointment (64.3% vs 47.6%, p < 0.001). Conclusion The co-location of a specialist metabolic clinic within a mental health service resulted in enhanced engagement and improvement of metabolic health in people with schizophrenia.
C1 [Siskind, Dan; Warren, Nicola; Kisely, Steve; Ray, Manaan Kar; Motamarri, Balaji] Metro South Addict & Mental Hlth Serv, Brisbane, Qld, Australia.
   [Siskind, Dan; Yen, Wesley; Thuzar, Moe; Russell, Anthony; Warren, Nicola; Kisely, Steve] Univ Queensland, Fac Med, Brisbane, Qld, Australia.
   [Yen, Wesley; Thuzar, Moe; Russell, Anthony] Princess Alexandra Hosp, Dept Endocrinol & Diabet, Brisbane, Qld, Australia.
   [Ray, Manaan Kar; Motamarri, Balaji] Griffith Univ, Sch Med, Brisbane, Qld, Australia.
C3 University of Queensland; Princess Alexandra Hospital; Griffith
   University
RP Siskind, D (corresponding author), Metro South Addict & Mental Hlth Serv, Brisbane, Qld, Australia.; Siskind, D (corresponding author), Univ Queensland, Fac Med, Brisbane, Qld, Australia.
EM d.siskind@uq.edu.au
RI Siskind, Dan/A-9812-2014; Thuzar, Moe/P-8576-2014; Russell,
   Anthony/A-8807-2011; Warren, Nicola/O-8355-2018
OI Siskind, Dan/0000-0002-2072-9216; Thuzar, Moe/0000-0001-6052-6096;
   Russell, Anthony/0000-0001-7886-8844; Kar Ray,
   Manaan/0000-0002-8497-7083; Warren, Nicola/0000-0002-0805-1182
FU NHMRC EL2 Fellowship [GNT1194635]
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship and/or publication of this article: DS is
   supported in part by an NHMRC EL2 Fellowship GNT1194635
CR Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
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NR 12
TC 1
Z9 1
U1 0
U2 1
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1039-8562
EI 1440-1665
J9 AUSTRALAS PSYCHIATRY
JI Australas. Psychiatry
PD AUG
PY 2022
VL 30
IS 4
BP 518
EP 522
AR 10398562221080742
DI 10.1177/10398562221080742
EA MAR 2022
PG 5
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 3T7CN
UT WOS:000776217800001
PM 35331017
DA 2025-06-11
ER

PT J
AU Lehrer, HM
   Steinhardt, MA
   Dubois, SK
   Laudenslager, ML
AF Lehrer, H. Matthew
   Steinhardt, Mary A.
   Dubois, Susan K.
   Laudenslager, Mark L.
TI Perceived stress, psychological resilience, hair cortisol concentration,
   and metabolic syndrome severity: A moderated mediation model
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE Stress; Resilience; HPA axis; Cardiovascular disease; Diabetes; Obesity
ID CORONARY-HEART-DISEASE; INDEPENDENT ASSOCIATIONS; DEPRESSIVE SYMPTOMS;
   RISK; SEX; STROKE; HEALTH; WOMEN; SCORE; MEN
AB Background: Psychological resilience is considered to protect against detrimental effects of perceived stress on cardiovascular and metabolic health, but few studies have tested biological mechanisms underlying these relationships.
   Purpose: This study examined whether psychological resilience moderated the indirect association of perceived stress with Metabolic Syndrome (MetS) severity via hair cortisol concentration (HCC), a retrospective index of hypothalamic pituitary adrenal (HPA) axis activity.
   Method: Participants included 228 adults (73 White, 86 Hispanic, 69 African American; mean age 45.29 years; 68% females). Participants completed questionnaires assessing perceived stress (Perceived Stress Scale) and resilience (Brief Resilience Scale). The first 3 cm of scalp-near hair were analyzed for cortisol concentration using enzyme-linked immunoassay analysis. Cardiometabolic risk factors including blood glucose, lipids, blood pressure, and waist circumference were assessed, from which a sex- and race/ethnicity-specific continuous MetS severity score was calculated. A moderated mediation model was tested using path analysis.
   Results: Psychological resilience moderated the association of perceived stress with HCC (R-2 change for interaction =-0.014, p = 0.043), such that the association of perceived stress and HCC decreased as resilience scores increased. Resilience also moderated the indirect association of perceived stress with MetS severity via HCC (b= -0.039, 95% CI [-0.001; -0.100]), such that HCC mediated the association of greater perceived stress with greater MetS severity only for individuals reporting Brief Resilience Scale scores 3 or below (range: 1.17-5.00). Psychological resilience was also associated with lower MetS severity (beta = -0.227, p= 0.014) independent of perceived stress and HCC.
   Conclusion: Findings suggest that psychological resilience may serve as both a stress buffer and as a direct determinant of cardiometabolic health. These results extend literature on psychological resilience to measures of retrospective HPA axis function and MetS severity in a diverse sample.
C1 [Lehrer, H. Matthew; Steinhardt, Mary A.; Dubois, Susan K.] Univ Texas Austin, Dept Kinesiol & Hlth Educ, Austin, TX 78712 USA.
   [Dubois, Susan K.] Univ Texas Austin, Dell Med Sch, Dept Internal Med, Austin, TX 78712 USA.
   [Laudenslager, Mark L.] Univ Colorado, Dept Psychiat, Anschutz Med Campus, Aurora, CO USA.
C3 University of Texas System; University of Texas Austin; University of
   Texas System; University of Texas Austin; University of Colorado System;
   University of Colorado Anschutz Medical Campus
RP Lehrer, HM (corresponding author), Univ Texas Austin, Dept Kinesiol & Hlth Educ, Austin, TX 78712 USA.
EM lehrerhm@upmc.edu
RI Laudenslager, Mark/D-1057-2018
FU St. David's Center for Health Promotion and Disease Prevention in
   Underserved Populations; American Heart Association [15SFDRN24180024];
   Administration for Children and Families [90YR0058]; American Heart
   Association (AHA) [15SFDRN24180024] Funding Source: American Heart
   Association (AHA)
FX This study was funded by a grant to Mary A. Steinhardt from the St.
   David's Center for Health Promotion and Disease Prevention in
   Underserved Populations. H. Matthew Lehrer received partial salary
   support during the analysis and interpretation of data and manuscript
   preparation by a University Continuing Fellowship. Mark L. Laudenslager
   received partial salary support during the preparation of this
   manuscript by contracts from the American Heart Association
   (15SFDRN24180024) and the Administration for Children and Families
   (90YR0058).
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NR 54
TC 56
Z9 60
U1 1
U2 41
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD MAR
PY 2020
VL 113
AR 104510
DI 10.1016/j.psyneuen.2019.104510
PG 8
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA LD3MV
UT WOS:000525937600019
PM 31911349
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Scharnholz, B
   Gilles, M
   Marzina, A
   Kommer, M
   Lederbogen, F
   Wudy, SA
   Hartmann, MF
   Westphal, S
   Roth, HJ
   Kahl, KG
   Meyer-Lindenberg, A
   Michaely, HJ
   Deuschle, M
AF Scharnholz, Barbara
   Gilles, Maria
   Marzina, Annika
   Kommer, Marcel
   Lederbogen, Florian
   Wudy, Stefan A.
   Hartmann, Michaela F.
   Westphal, Sabine
   Roth, Heinz Juergen
   Kahl, Kai G.
   Meyer-Lindenberg, Andreas
   Michaely, Henrik J.
   Deuschle, Michael
TI Do depressed patients without activation of the hypothalamus pituitary
   adrenal (HPA) system have metabolic disturbances?
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE Depression; Metabolic syndrome; HPA system; Autonomic nervous system;
   Btood pressure; Fasting glucose; Body composition; Visceral fat
ID IMPROVED INSULIN SENSITIVITY; BLOOD-PRESSURE; HYPERCORTISOLEMIC
   DEPRESSION; ATYPICAL DEPRESSION; CORTISOL SECRETION; GLUCOSE-TOLERANCE;
   MAJOR DEPRESSION; SERUM-LIPIDS; LARGE-COHORT; ASSOCIATION
AB This study compared features of the metabolic syndrome between healthy controls and depressed patients without activation of the hypothalamus pituitary adrenal (HPA) system. After exclusion of non-suppressors to 1 mg dexamethasone, we included 20 depressed inpatients and 34 healthy controls in the analyses. We assessed HPA system activity (diurnal saliva cortisol profile, cortisol excretion), normetanephrine excretion as well as fasting glucose, lipid profile and blood pressure. With regard to body composition, we measured waist circumference as well as visceral fat and adrenal volume by magnetic resonance (MR) imaging. Five depressed patients (25%) and five healthy controls (15%) fulfilled the criteria of the metabolic syndrome according NCEP-ATP-111. Depression was significantly related with fasting glucose and negatively associated with mean blood pressure (BP) and, by trend, with low HDL-cholesterol. We conclude that depressed patients may have modest metabolic disturbances even in the complete absence of activation of stress-responsive systems. Hence some metabolic disturbances in depressed patients may not be explicable by HPA activation. Additional factors are required to mediate the link between affective and metabolic disorders. (C) 2013 Elsevier Ltd. All rights reserved.
C1 [Scharnholz, Barbara; Gilles, Maria; Lederbogen, Florian; Meyer-Lindenberg, Andreas; Deuschle, Michael] Heidelberg Univ, Med Fac Mannheim, Cent Inst Mental Hlth, Dept Psychiat & Psychotherapy, D-68159 Mannheim, Germany.
   [Marzina, Annika; Kommer, Marcel; Michaely, Henrik J.] Univ Med Ctr Mannheim, Inst Clin Radiol & Nucl Med, D-68167 Mannheim, Germany.
   [Wudy, Stefan A.; Hartmann, Michaela F.] Univ Giessen, Ctr Child & Adolescent Med, Div Pediat Endocrinol & Diabetol, Steroid Res & Mass Spectrometry Unit, D-35390 Giessen, Germany.
   [Westphal, Sabine] Magdeburg Univ Hosp, Inst Clin Chem, D-39120 Magdeburg, Germany.
   [Roth, Heinz Juergen] Lab Limbach, D-69126 Heidelberg, Germany.
   [Kahl, Kai G.] Leibniz Univ Hannover, Dept Psychiat Social Psychiat & Psychotherapy, D-30625 Hannover, Germany.
C3 Central Institute of Mental Health; Ruprecht Karls University
   Heidelberg; Ruprecht Karls University Heidelberg; Justus Liebig
   University Giessen; University Hospital Magdeburg; Leibniz University
   Hannover
RP Scharnholz, B (corresponding author), Heidelberg Univ, Med Fac Mannheim, Cent Inst Mental Hlth, Dept Psychiat & Psychotherapy, D-68159 Mannheim, Germany.
EM barbara.scharnholz@zi-mannheim.de
RI Wudy, Stefan/ABC-7173-2020; Meyer-Lindenberg, Andreas/H-1076-2011
OI Meyer-Lindenberg, Andreas/0000-0001-5619-1123
CR Arnaldi G, 2010, NEUROENDOCRINOLOGY, V92, P86, DOI 10.1159/000314213
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NR 47
TC 18
Z9 19
U1 0
U2 10
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD JAN
PY 2014
VL 39
BP 104
EP 110
DI 10.1016/j.psyneuen.2013.09.030
PG 7
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA AA0WM
UT WOS:000330818100011
PM 24275009
DA 2025-06-11
ER

PT J
AU Gerber, M
   Börjesson, M
   Ljung, T
   Lindwall, M
   Jonsdottir, IH
AF Gerber, Markus
   Borjesson, Mats
   Ljung, Thomas
   Lindwall, Magnus
   Jonsdottir, Ingibjoerg H.
TI Fitness Moderates the Relationship between Stress and Cardiovascular
   Risk Factors
SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
LA English
DT Article
DE BLOOD PRESSURE; CHOLESTEROL; TRIGLYCERIDES; BMI; HEMOGLOBIN A1c
ID ISCHEMIC-HEART-DISEASE; ALL-CAUSE MORTALITY; PHYSICAL-ACTIVITY;
   CARDIORESPIRATORY FITNESS; PSYCHOSOCIAL STRESS; PSYCHOLOGICAL RESPONSES;
   MYOCARDIAL-INFARCTION; BLOOD-PRESSURE; EXERCISE; LEVEL
AB Purpose This cross-sectional observational study examined the degree to which cardiorespiratory fitness (CRF) and self-perceived stress are associated with cardiometabolic risk factors and the overall risk score for cardiovascular diseases. The second aim was to determine whether participants' CRF levels moderate the relationships between stress and cardiometabolic risk.
   Methods A gender-matched stratified sample (N = 197, 51% men, M-age = 39.2 yr) was used to ensure that participants with varying stress levels were equally represented. CRF was assessed with the angstrom strand bicycle test, and perceived stress was assessed with a single-item question. Systolic blood pressure (SBP) and diastolic blood pressure (DBP), body mass index (BMI), total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), glycated hemoglobin, and total cardiometabolic risk score (sum of the z-standardized residuals of the previously mentioned indicators) were assessed as outcomes.
   Results Higher LDL-C, TG, and total metabolic risk were found in participants with high stress scores (P < 0.05). In addition, lower SBP, DBP, BMI, LDL-C, TG, and total metabolic risk were observed in participants with high CRF (P < 0.05). Two-way ANCOVA provided significant interaction effects for five of the nine outcome variables (P < 0.05, 3.6%-4.8% of explained variance). Participants with high stress who also had high CRF levels had lower SBP, DBP, LDL-C, TG, and total cardiometabolic risk than participants with high stress but low or moderate CRF levels. No significant main or interaction effects occurred for BMI, total cholesterol, high-density lipoprotein cholesterol, and glycated hemoglobin.
   Conclusion Better CRF is associated with more favorable levels of several cardiometabolic risk factors, specifically in participants experiencing high stress. Higher CRF may provide some protection against the health hazards of high chronic stress by attenuating the stress-related increase in cardiovascular risk factors.
C1 [Gerber, Markus] Univ Basel, Dept Sport Exercise & Hlth, Birsstr 320B, CH-4052 Basel, Switzerland.
   [Borjesson, Mats] Univ Gothenburg, Sahlgrenska Acad, Dept Physiol, Gothenburg, Sweden.
   [Borjesson, Mats] Ostra Hosp, Gothenburg, Sweden.
   [Borjesson, Mats; Lindwall, Magnus; Jonsdottir, Ingibjoerg H.] Univ Gothenburg, Dept Food & Nutr & Sport Sci, Gothenburg, Sweden.
   [Ljung, Thomas] Mid Sweden Univ, Dept Hlth Sci, Sundsvall, Sweden.
   [Lindwall, Magnus] Univ Gothenburg, Dept Psychol, Gothenburg, Sweden.
   [Jonsdottir, Ingibjoerg H.] Inst Stress Med, Gothenburg, Sweden.
C3 University of Basel; Swiss School of Public Health (SSPH+); University
   of Gothenburg; Sahlgrenska University Hospital; University of
   Gothenburg; Mid-Sweden University; University of Gothenburg
RP Gerber, M (corresponding author), Univ Basel, Dept Sport Exercise & Hlth, Birsstr 320B, CH-4052 Basel, Switzerland.
EM markus.gerber@unibas.ch
RI Gerber, Markus/H-8654-2014
OI Gerber, Markus/0000-0001-6140-8948
FU Swedish government
FX The authors gratefully acknowledge the valuable help of Anna Rutgersson,
   Anneli Samuelsson, Sandra Pettersson, and Hans Mandelholm for performing
   the cycle tests; Karin Nygren and Marie-Louise Norberg for supervising
   the screening and inclusion procedures and data collection; and Flora
   Colledge for proofreading the manuscript. They also thank all
   participants for their valuable time and contributions to the study.
   Funding for this study was provided by the Swedish government, which had
   no further role in the study design, collection, analysis,
   interpretation of data, writing of this report, and decision to submit
   this paper for publication. The authors alone are responsible for the
   content and writing of the paper. They declare no conflict of interest.
   All authors have read and approved the manuscript. Finally, the authors
   acknowledge that the results of the present study do not constitute
   endorsement by the American College of Sports Medicine.
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NR 40
TC 29
Z9 31
U1 1
U2 16
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0195-9131
EI 1530-0315
J9 MED SCI SPORT EXER
JI Med. Sci. Sports Exerc.
PD NOV
PY 2016
VL 48
IS 11
BP 2075
EP 2081
DI 10.1249/MSS.0000000000001005
PG 7
WC Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Sport Sciences
GA EA4OU
UT WOS:000386593200001
PM 27285493
DA 2025-06-11
ER

PT J
AU Clemente-Suárez, VJ
   Mielgo-Ayuso, J
   Martín-Rodríguez, A
   Ramos-Campo, DJ
   Redondo-Flórez, L
   Tornero-Aguilera, JF
AF Javier Clemente-Suarez, Vicente
   Mielgo-Ayuso, Juan
   Martin-Rodriguez, Alexandra
   Jesus Ramos-Campo, Domingo
   Redondo-Florez, Laura
   Francisco Tornero-Aguilera, Jose
TI The Burden of Carbohydrates in Health and Disease
SO NUTRIENTS
LA English
DT Review
DE metabolic disease; cancer; gut microbiome; asthma; nutrition;
   carbohydrates
ID WHOLE-GRAIN INTAKE; DIETARY GLYCEMIC LOAD; CHRONIC KIDNEY-DISEASE;
   ALL-CAUSE MORTALITY; BODY-MASS INDEX; GUT MICROBIOTA;
   CARDIOVASCULAR-DISEASE; COGNITIVE PERFORMANCE; DIABETES-MELLITUS;
   PRACTICE GUIDELINES
AB Foods high in carbohydrates are an important part of a healthy diet, since they provide the body with glucose to support bodily functions and physical activity. However, the abusive consumption of refined, simple, and low-quality carbohydrates has a direct implication on the physical and mental pathophysiology. Then, carbohydrate consumption is postulated as a crucial factor in the development of the main Western diseases of the 21st century. We conducted this narrative critical review using MedLine (Pubmed), Cochrane (Wiley), Embase, and CinAhl databases with the MeSH-compliant keywords: carbohydrates and evolution, development, phylogenetic, GUT, microbiota, stress, metabolic health, consumption behaviors, metabolic disease, cardiovascular disease, mental disease, anxiety, depression, cancer, chronic kidney failure, allergies, and asthma in order to analyze the impact of carbohydrates on health. Evidence suggests that carbohydrates, especially fiber, are beneficial for the well-being and growth of gut microorganisms and consequently for the host in this symbiotic relationship, producing microbial alterations a negative effect on mental health and different organic systems. In addition, evidence suggests a negative impact of simple carbohydrates and refined carbohydrates on mood categories, including alertness and tiredness, reinforcing a vicious circle. Regarding physical health, sugar intake can affect the development and prognosis of metabolic disease, as an uncontrolled intake of refined carbohydrates puts individuals at risk of developing metabolic syndrome and subsequently developing metabolic disease.
C1 [Javier Clemente-Suarez, Vicente; Martin-Rodriguez, Alexandra; Francisco Tornero-Aguilera, Jose] Univ Europea Madrid, Fac Sports Sci, Tajo St S-N, Madrid 28670, Spain.
   [Javier Clemente-Suarez, Vicente] Univ La Costa, Grp Invest Cultura Educ & Soc, Barranquilla 080002, Colombia.
   [Javier Clemente-Suarez, Vicente; Francisco Tornero-Aguilera, Jose] Studies Ctr Appl Combat CESCA, Toledo 45007, Spain.
   [Mielgo-Ayuso, Juan] Univ Burgos, Fac Hlth Sci, Dept Hlth Sci, Burgos 09001, Spain.
   [Jesus Ramos-Campo, Domingo] Univ Politecn Madrid, Fac Phys Act & Sport Sci INEF, Dept Hlth & Human Performance, LFE Res Grp, Madrid 28670, Spain.
   [Redondo-Florez, Laura] Univ Europea Madrid, Fac Biomed & Hlth Sci, Dept Hlth Sci, C Tajo S-N, Madrid 28670, Spain.
C3 European University of Madrid; Universidad de la Costa; Universidad de
   Burgos; Universidad Politecnica de Madrid; Facultad de Ciencias de la
   Actividad Fisica del Deporte (INEF); European University of Madrid
RP Clemente-Suárez, VJ (corresponding author), Univ Europea Madrid, Fac Sports Sci, Tajo St S-N, Madrid 28670, Spain.; Clemente-Suárez, VJ (corresponding author), Univ La Costa, Grp Invest Cultura Educ & Soc, Barranquilla 080002, Colombia.; Clemente-Suárez, VJ (corresponding author), Studies Ctr Appl Combat CESCA, Toledo 45007, Spain.; Ramos-Campo, DJ (corresponding author), Univ Politecn Madrid, Fac Phys Act & Sport Sci INEF, Dept Hlth & Human Performance, LFE Res Grp, Madrid 28670, Spain.
EM vctxente@yahoo.es; domingojesusramos@gmail.com
RI RAMOS, DOMINGO JESÚS/O-3283-2016; Mielgo-Ayuso, Juan/E-7525-2019; Martín
   Rodríguez, Alexandra/ISV-0813-2023; Clemente-Suarez, Vicente
   Javier/K-7980-2014
OI Ramos-Campo, Domingo Jesus/0000-0002-8890-4244; REDONDO FLOREZ,
   LAURA/0000-0002-1006-7642; Tornero Aguilera, Jose
   Francisco/0000-0002-0747-8133; Clemente-Suarez, Vicente
   Javier/0000-0002-2397-2801; Mielgo Ayuso, Juan/0000-0002-6554-4602;
   MARTIN-RODRIGUEZ, ALEXANDRA/0000-0002-0087-4379
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NR 267
TC 67
Z9 69
U1 9
U2 66
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD SEP
PY 2022
VL 14
IS 18
AR 3809
DI 10.3390/nu14183809
PG 28
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 4R5HW
UT WOS:000856796000001
PM 36145184
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Carney, R
   Imran, S
   Law, H
   Carmichael-Murphy, P
   Charlton, L
   Parker, S
AF Carney, Rebekah
   Imran, Shermin
   Law, Heather
   Carmichael-Murphy, Parise
   Charlton, Leah
   Parker, Sophie
TI "If you're struggling, you don't really care" - what affects the
   physical health of young people on child and adolescent mental health
   inpatient units? A qualitative study with service users and staff
SO BMC PSYCHIATRY
LA English
DT Article
DE Inpatient; Physical health; Qualitative; Adolescent; Child; Mental
   health
ID ULTRA-HIGH RISK; CARDIOMETABOLIC RISK; METABOLIC SYNDROME; WEIGHT-GAIN;
   LIFE-STYLE; PSYCHOSIS; OUTCOMES; ILLNESS; SCHIZOPHRENIA; INTERVENTIONS
AB BackgroundPhysical health inequalities of people with serious mental illness (SMI) have been labelled an international scandal; due to the 15-20-year reduction in life expectancy associated with poor physical health. This occurs at an early stage and evidence shows young people with and at risk for SMI are a particularly vulnerable group requiring intervention and support. However, most work has been conducted with adults and little is known about what affects physical health for young people, specifically those receiving inpatient care.MethodsWe conducted semi-structured qualitative interviews with 7 service users and 6 staff members (85% female, age 14-42) on a generic mental health inpatient unit for children and adolescents. Interviews aimed to identify how young people viewed theirphysical health and factors affecting physical health and lifestyle and identify any support needed to improve physical health. Thematic analysis was conducted. .ResultsThematic analysis revealed the main factors affecting physical health and lifestyle for young people. Three main themes were individual factors (subthemes were mental health symptoms, knowledge, attitudes and beliefs), environmental factors (subthemes were opportunities in a restricted environment and food provision), and the influence of others (subthemes were peers, staff, family members). These factors often overlapped and could promote a healthy lifestyle or combine to increase the risk of poor physical health. Young people discussed their preferences for physical health initiatives and what would help them to live a healthier lifestyle.ConclusionsPromoting physical health on inpatient units for young people is an important, yet neglected area of mental health research. We have identified a range of complex factors which have an impact on their physical health, and there is a pervasive need to address the barriers that young people experience to living a healthy lifestyle. There is an increasingly strong evidence base suggesting the benefits of physical health interventions to improve outcomes, and future work should identify ways to implement such interventions considering the barriers discussed in this article. Further collaborative research is needed with young people, clinical teams, caregivers, and commissioners to ensure improvements are made to clinical care provision and optimisation of the inpatient environment.
C1 [Carney, Rebekah; Law, Heather; Carmichael-Murphy, Parise; Charlton, Leah; Parker, Sophie] Greater Manchester Mental Hlth NHS Fdn Trust, Youth Mental Hlth Res Unit, Manchester M25 3BL, England.
   [Carney, Rebekah; Carmichael-Murphy, Parise; Charlton, Leah; Parker, Sophie] Univ Manchester, Fac Biol Med & Hlth, Div Psychol & Mental Hlth, Manchester M13 9PL, England.
   [Imran, Shermin] Greater Manchester Mental Hlth NHS Fdn Trust, Bury New Rd, Prestwich M13 3BL, England.
C3 University of Manchester
RP Carney, R (corresponding author), Greater Manchester Mental Hlth NHS Fdn Trust, Youth Mental Hlth Res Unit, Manchester M25 3BL, England.; Carney, R (corresponding author), Univ Manchester, Fac Biol Med & Hlth, Div Psychol & Mental Hlth, Manchester M13 9PL, England.
EM Rebekah.carney@gmmh.nhs.uk
RI Carmichael-Murphy, Parise/JYQ-3376-2024; Carney, Rebekah/AAO-5205-2021
OI Parker, Sophie/0000-0001-5596-7524
FU Greater Manchester Mental Health NHS Foundation Trust
FX The funding for this research came from internal NHS Research Capability
   Funding at Greater Manchester Mental Health NHS Foundation Trust.
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NR 42
TC 0
Z9 0
U1 2
U2 4
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-244X
J9 BMC PSYCHIATRY
JI BMC Psychiatry
PD JUL 9
PY 2024
VL 24
IS 1
AR 498
DI 10.1186/s12888-024-05858-1
PG 15
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychiatry
GA YA5N6
UT WOS:001265778200002
PM 38982436
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Lee, BK
   Kim, Y
   Kim, YI
AF Lee, Byung-Kook
   Kim, Yangho
   Kim, Young-Il
TI Association of serum ferritin with metabolic syndrome and diabetes
   mellitus in the South Korean general population according to the Korean
   National Health and Nutrition Examination Survey 2008
SO METABOLISM-CLINICAL AND EXPERIMENTAL
LA English
DT Article
ID BODY IRON STORES; CARDIOVASCULAR RISK-FACTORS; INSULIN-RESISTANCE
   SYNDROME; GLUCOSE-INTOLERANCE; OXIDATIVE STRESS; FATTY LIVER; MEN;
   HYPERINSULINEMIA; WOMEN; INFLAMMATION
AB We examined the association of serum ferritin levels with metabolic syndrome (MS) and diabetes mellitus in a representative sample of the adult South Korean population using data from the 2008 Korean National Health and Nutrition Examination Survey. We conducted a cross-sectional study of 6311 adults older than 20 years who participated in the 2008 Korean National Health and Nutrition Examination Survey. Metabolic syndrome was defined as the presence of at least 3 of the following: elevated blood pressure, low high-density lipoprotein cholesterol, elevated serum triglycerides, elevated plasma glucose, and abdominal obesity. Diabetes mellitus was defined as fasting glucose of at least 126 mg/dL. Insulin resistance was determined using the homeostasis model assessment estimate of insulin resistance. In a representative sample of the adult Korean population, MS was more prevalent in the highest quartile compared with the lowest quartile of serum ferritin concentrations in women following adjustments for age, education, smoking, alcohol intake, body mass index, aspartate aminotransferase, and alanine aminotransferase. Diabetes mellitus was more prevalent in the highest quartile compared with the lowest quartile of serum ferritin concentrations in premenopausal women and men. The geometric means of fasting insulin and insulin resistance determined using the homeostasis model assessment of insulin resistance in the fourth serum ferritin quartiles of postmenopausal women and men were significantly higher compared with those in the first quartile of the respective groups. The present study demonstrates that elevated serum ferritin concentrations are associated with an increased risk of MS and diabetes mellitus in a representative sample of the adult South Korean population. (C) 2011 Published by Elsevier Inc.
C1 [Kim, Yangho] Univ Ulsan Coll Med, Dept Occupat & Environm Med, Ulsan Univ Hosp, Ulsan 682060, South Korea.
   [Lee, Byung-Kook] Soonchunhyang Univ 646 Eupnae Ri, Inst Environm & Occupat Med, Asan 336745, Choongnam, South Korea.
   [Kim, Young-Il] Univ Ulsan Coll Med, Div Endocrinol & Metab, Dept Internal Med, Ulsan Univ Hosp, Ulsan 682060, South Korea.
C3 University of Ulsan; Ulsan University Hospital; Soonchunhyang
   University; University of Ulsan; Ulsan University Hospital
RP Kim, Y (corresponding author), Univ Ulsan Coll Med, Dept Occupat & Environm Med, Ulsan Univ Hosp, Ulsan 682060, South Korea.
EM yanghokm@nuri.net
RI Kim, Yong-Jae/JQW-5758-2023
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NR 55
TC 87
Z9 87
U1 0
U2 2
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0026-0495
EI 1532-8600
J9 METABOLISM
JI Metab.-Clin. Exp.
PD OCT
PY 2011
VL 60
IS 10
BP 1416
EP 1424
DI 10.1016/j.metabol.2011.02.008
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 826IN
UT WOS:000295347900010
PM 21489582
DA 2025-06-11
ER

PT J
AU Tsigos, C
   Chrousos, GP
AF Tsigos, C
   Chrousos, GP
TI Hypothalamic-pituitary-adrenal axis, neuroendocrine factors and stress
SO JOURNAL OF PSYCHOSOMATIC RESEARCH
LA English
DT Article
DE stress; glucocorticoids; corticotropin-releasing hormone or factor (CRH
   or CRF)
ID CORTICOTROPIN-RELEASING HORMONE; RECOMBINANT HUMAN INTERLEUKIN-6;
   BIOCHEMICAL MANIFESTATIONS; NERVOUS-SYSTEM; BETA-ENDORPHIN; SECRETION;
   DEPRESSION; RECEPTORS; IMMUNE; BRAIN
AB The stress system coordinates the adaptive responses of the organism to stressors of any kind.(1) The main components of the stress system are the corticotropin-releasing hormone (CRH) and locus ceruleus-norepinephrine (LC/NE)-autonomic systems and their peripheral effectors, the pituitary-adrenal axis, and the limbs of the autonomic system. Activation of the stress system leads to behavioral and peripheral changes that improve the ability of the organism to adjust homeostasis and increase its chances for survival. The CRH and LC/NE systems stimulate arousal and attention, as well as the mesocorticolimbic dopaminergic system, which is involved in anticipatory and reward phenomena, and the hypothalamic beta-endorphin system, which suppresses pain sensation and, hence, increases analgesia. CRH inhibits appetite and activates thermogenesis via the catecholaminergic system. Also, reciprocal interactions exist between the amygdala and the hippocampus and the stress system, which stimulates these elements and is regulated by them. CRH plays an important role in inhibiting GnRH secretion during stress, while, via somatostatin, it also inhibits GH, TRH and TSH secretion, suppressing, thus, the reproductive, growth and thyroid functions. Interestingly, all three of these functions receive and depend on positive catecholarninergic input. The end-hormones of the hypothalamic-pituitary-adrenal (HPA) axis, glucocorticoids, on the other hand, have multiple roles. They simultaneously inhibit the CRH, LCNE and beta-endorphin systems and stimulate the mesocorticolimbic dopaminergic system and the CRH peptidergic central nucleus of the amygdala. In addition, they directly inhibit pituitary gonadotropin, GH and TSH secretion, render the target tissues of sex steroids and growth factors resistant to these substances and suppress the 5' deiodinase, which converts the relatively inactive tetraiodothyronine (T-4) to triiodothyronine (T-3) contributing further to the suppression of reproductive, growth and thyroid functions. They also have direct as well as insulin-mediated effects on adipose tissue, ultimately promoting visceral adiposity, insulin resistance, dyslipidemia and hypertension (metabolic syndrome X) and direct effects on the bone, causing "low turnover" osteoporosis. Central CRH, via glucocorticoids and catecholamines, inhibits the inflammatory reaction, while directly secreted by peripheral nerves CRH stimulates local inflammation (immune CRH). CRH antagonists may be useful in human pathologic states, such as melancholic depression and chronic anxiety, associated with chronic hyperactivity of the stress system, along with predictable behavioral, neuroendocrine, metabolic and immune changes, based on the interrelations outlined above. Conversely, potentiators of CRH secretion/action may be useful to treat atypical depression, postpartum depression and the fibromyalgia/chronic fatigue syndromes, all characterized by low HPA axis and LCNE activity, fatigue, depressive symptomatology, hyperalgesia and increased immune/inflammatory responses to stimuli. (C) 2002 Elsevier Science Inc. All rights reserved.
C1 NICHHD, Pediat & Reprod Endocrinol Branch, NIH, Bethesda, MD 20892 USA.
   Univ Athens, Sch Med, GR-11527 Athens, Greece.
   Hellen Natl Diabet Ctr, Athens, Greece.
C3 National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver
   National Institute of Child Health & Human Development (NICHD); Athens
   Medical School; National & Kapodistrian University of Athens
RP NICHHD, Pediat & Reprod Endocrinol Branch, NIH, Bldg 10,Rm 9D42, Bethesda, MD 20892 USA.
EM chrousog@mail.nih.gov
RI Chrousos, George/G-8702-2011
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NR 47
TC 1869
Z9 2368
U1 10
U2 552
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-3999
EI 1879-1360
J9 J PSYCHOSOM RES
JI J. Psychosomat. Res.
PD OCT
PY 2002
VL 53
IS 4
BP 865
EP 871
AR PII S0022-3999(02)00429-4
DI 10.1016/S0022-3999(02)00429-4
PG 7
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 606ME
UT WOS:000178737100006
PM 12377295
DA 2025-06-11
ER

PT J
AU Al Badarin, FJ
   From, AM
   McCully, RB
   Lopez-Jimenez, F
AF Al Badarin, Firas J.
   From, Aaron M.
   McCully, Robert B.
   Lopez-Jimenez, Francisco
TI Likelihood of obstructive coronary disease in metabolic syndrome
   patients with abnormal stress echocardiography
SO INTERNATIONAL JOURNAL OF CARDIOLOGY
LA English
DT Article
DE Metabolic syndrome; Stress echocardiography; Coronary angiography;
   Impaired fasting glucose
ID 3RD NATIONAL-HEALTH; CARDIAC SYNDROME-X; EXERCISE ECHOCARDIOGRAPHY;
   CARDIOVASCULAR-DISEASE; WAIST CIRCUMFERENCE; ARTERY-DISEASE;
   CLINICAL-APPLICATIONS; SYNDROME SCORE; FOLLOW-UP; RISK
AB Background: Metabolic syndrome (MetSx) encompasses several risk factors for macrovascular coronary artery disease. An association between MetSx and coronary syndrome X has also been reported, suggesting that patients with MetSx are more likely to have endothelial dysfunction in the setting of angiographically normal coronary arteries. It remains unknown whether MetSx patients with abnormal stress echocardiography (SE) are more likely to have obstructive coronary disease (CAD) compared to patients without MetSx.
   Methods: We identified symptomatic patients without known CAD and abnormal SE who underwent coronary angiography within 4 weeks after the SE. Patients were grouped according to their MetSx and impaired fasting glucose (IFG) status. We compared the proportion of patients with obstructive CAD in each subgroup using the x(2) test. Multivariate regression analysis was used to adjust for the pre-test probability of underlying coronary artery disease.
   Results: Among 583 consecutive symptomatic patients who had an abnormal SE and were referred for angiography, 158 (36%) met the NCEP definition of MetSx. MetSx patients had a trend towards having more obstructive CAD than those without MetSx (OR 1.44, p = 0.07). After adjusting for pre-test probability of coronary disease, smoking and LDL-C, MetSx/IFG combination was an independent predictor of obstructive CAD (OR 2.06 [1.24-3.44], p<0.001) but MetSx with normal fasting blood glucose was not (OR 0.91 [0.47-1.70], p 0.09).
   Conclusion: Symptomatic patients with MetSx and IFG are more likely to have angiographically significant CAD after abnormal SE than patients without MetSx or those with normal fasting blood glucose. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
C1 [Lopez-Jimenez, Francisco] Mayo Clin, Dept Med, Div Cardiovasc Dis, Sch Med, Rochester, MN 55905 USA.
   Mayo Fdn, Rochester, MN 55905 USA.
C3 Mayo Clinic; Mayo Clinic
RP Lopez-Jimenez, F (corresponding author), Mayo Clin, Dept Med, Div Cardiovasc Dis, Sch Med, 200 1st St SW, Rochester, MN 55905 USA.
EM lopez@mayo.edu
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NR 40
TC 2
Z9 2
U1 0
U2 0
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0167-5273
EI 1874-1754
J9 INT J CARDIOL
JI Int. J. Cardiol.
PD OCT 20
PY 2011
VL 152
IS 2
BP 207
EP 211
DI 10.1016/j.ijcard.2010.07.017
PG 5
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 841UQ
UT WOS:000296540800017
PM 20674994
DA 2025-06-11
ER

PT J
AU Muhtaroglu, S
   Koçak, SÖ
   Çetin, I
   Keti, DB
   Kendirci, M
AF Muhtaroglu, Sabahattin
   Kocak, Selda Ozkan
   Cetin, Ihsan
   Keti, Didem Barlak
   Kendirci, Mustafa
TI Investigation of ischemia modified albumin and coenzyme Q10 levels in
   obese children with metabolic syndrome
SO TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
LA English
DT Article
DE Ischemia modified albumin; Coenzyme Q10; Childhood obesity; Metabolic
   syndrome; Lipid profile
ID OXIDATIVE STRESS BIOMARKER; BODY-MASS INDEX; RISK-FACTORS;
   SUPPLEMENTATION; ASSOCIATIONS; ANTIOXIDANT; ADOLESCENTS; CHILDHOOD;
   LIPIDS; Q(10)
AB Introduction: The aim of this study was to analyze serum ischemia modified albumin (IMA) and plasma CoQ10 levels and to evaluate their correlation with insulin resistance (homeostatic model assessment, HOMA) and lipid profile in obese children with and without metabolic syndrome (MS).
   Methods: Thirty-one obese with MS, 30 obese without MS and 34 healthy children aged 6-18 years were included in the study. Serum IMA was measured by colorimetric method, plasma CoQ10 levels were measured by HPLC. Serum glucose, total cholesterol, triglyceride, high density lipoprotein cholesterol, low density lipoprotein cholesterol and insulin were analyzed.
   Results: IMA levels were found to be significantly higher (p < 0.001) while the CoQ10 levels were significantly lower (p < 0.001) in obese children with and without MS compared to controls. IMA and CoQ10 significantly correlated with each other and metabolic parameters. Furthermore, IMA and CoQ10 levels did not significantly differ between obese children with and without MS, while glucose, insulin levels and HOMA were significantly higher (p < 0.001) in obese children with MS than obese without MS and controls.
   Conclusions: Based on the high levels of IMA, low CoQ10 and association with HOMA and lipid profile; we suggest that obese children may have oxidative damage, lipid peroxidation and cardiometabolic risk.
C1 [Cetin, Ihsan] Batman Univ, Saglik Yuksek Okulu, Beslenme & Diyetet Bolumu, Batman, Turkey.
   [Muhtaroglu, Sabahattin; Keti, Didem Barlak] Erciyes Univ, Tip Faku, Tibbi Biyokimya Bolumu, Kayseri, Turkey.
   [Kocak, Selda Ozkan] Erciyes Univ, Tip Faku, Metab Lab, Kayseri, Turkey.
   [Kendirci, Mustafa] Erciyes Univ, Tip Faku, Pediat Endokrinol Bolumu, Kayseri, Turkey.
C3 Batman University; Erciyes University; Erciyes University; Erciyes
   University
RP Çetin, I (corresponding author), Batman Univ, Saglik Yuksek Okulu, Beslenme & Diyetet Bolumu, Batman, Turkey.
EM cetinihsan@gmail.com
RI muhtaroglu, sabahattin/ABE-5843-2020; Keti, Didem/AAT-2996-2021
FU Scientific Research Projects Unit of Erciyes University [TSY-10-2890]
FX This research work was funded by the Scientific Research Projects Unit
   of Erciyes University (Project number: TSY-10-2890). We are grateful to
   all participants and everyone who contributed to this research.
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NR 39
TC 0
Z9 0
U1 0
U2 5
PU WALTER DE GRUYTER GMBH
PI BERLIN
PA GENTHINER STRASSE 13, D-10785 BERLIN, GERMANY
SN 0250-4685
EI 1303-829X
J9 TURK J BIOCHEM
JI Turk. J. Biochem.
PD DEC
PY 2016
VL 41
IS 6
BP 443
EP 449
DI 10.1515/tjb-2016-0147
PG 7
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA EJ4OU
UT WOS:000393197500009
OA gold
DA 2025-06-11
ER

PT J
AU Maity, S
   Abbaspour, R
   Bandelow, S
   Pahwa, S
   Alahdadi, T
   Shah, SR
   Chhetri, P
   Jha, AK
   Nauhria, S
   Nath, R
   Nayak, N
   Nauhria, S
AF Maity, Sabyasachi
   Abbaspour, Raman
   Bandelow, Stephan
   Pahwa, Sehaj
   Alahdadi, Taraneh
   Shah, Sharan
   Chhetri, Praghosh
   Jha, Ameet Kumar
   Nauhria, Shreya
   Nath, Reetuparna
   Nayak, Narendra
   Nauhria, Samal
TI The psychosomatic impact of Yoga in medical education: a systematic
   review and meta-analysis
SO MEDICAL EDUCATION ONLINE
LA English
DT Review
DE Yoga; medical student; systematic review; medical education;
   meta-analysis; physiology; Anxiety; stress; academic performance
ID NOSTRIL BREATHING EXERCISE; PULMONARY-FUNCTION; RESPIRATORY FUNCTIONS;
   METABOLIC SYNDROME; PERCEIVED STRESS; STUDENT STRESS; BLOOD-PRESSURE;
   HEART-RATE; ANXIETY; HEALTH
AB Non-clinical approaches such as meditation, yoga, and mindfulness are popular traditional therapeutical interventions adopted by many educational institutions to improve the physical and mental well-being of learners. This study aimed to evaluate the effectiveness of yoga intervention in improving cardiopulmonary parameters such as blood pressure, heart rate, pulmonary function tests and psychosomatic symptoms such as depression, anxiety and stress in medical and dental students. Using the PRISMA protocol, a search from databases such as PubMed, Scopus, and Embase resulted in 304 relevant articles. After screening the title and abstracts, 47 papers were analyzed thoroughly and included in the qualitative analysis. 18 articles with homogenous statistical data on physiology and psychological parameters were included for meta-analysis. In comparison to the control group, the study showed a significant reduction of systolic blood pressure (SBP: 6.82 mmHg, z = -3.06, p = 0.002), diastolic blood pressure (DBP: 2.92 mmHg, z = -2.22, p = 0.03), and heart rate (HR: 2.55 beats/min, z = -2.77, p = 0.006). Additionally, data from 4 studies yielded a significant overall effect of a stress reduction of 0.77 on standardized assessments due to the yoga intervention (z = 5.29, p < 0.0001). Lastly, the results also showed a significant (z = -2.52, p = 0.01) reduction of 1.2 in standardized anxiety tests in intervention group compared to the control. The findings offer promising prospects for medical educators globally, encouraging them to consider reformation and policymaking in medical curricula to enhance academic success and improve the overall quality of life for medical students worldwide.
C1 [Maity, Sabyasachi; Bandelow, Stephan] St Georges Univ, Dept Physiol Neurosci & Behav Sci, Sch Med, True Blue, Grenada.
   [Abbaspour, Raman] York Univ, Dept Elect Engn & Comp Sci, Toronto, ON, Canada.
   [Pahwa, Sehaj; Alahdadi, Taraneh; Shah, Sharan] St Georges Univ, Med Student Res Inst, Sch Med, True Blue, Grenada.
   [Chhetri, Praghosh] St Matthews Univ, Dept Physiol, Sch Med, Georgetown, Cayman Islands.
   [Jha, Ameet Kumar] St Matthews Univ, Dept Anat Sci, Sch Med, Georgetown, Cayman Islands.
   [Nauhria, Shreya] Cayman Islands Red Cross, Dept Child Protect, Georgetown, Cayman Islands.
   [Nath, Reetuparna] St Georges Univ, Dept Educ Serv, Sch Med, True Blue, Grenada.
   [Nayak, Narendra] St Matthews Univ, Dept Microbiol, Sch Med, Georgetown, Cayman Islands.
   [Nauhria, Samal] St Matthews Univ, Dept Pathol, Sch Med, Georgetown, Cayman Islands.
C3 York University - Canada
RP Nauhria, S (corresponding author), St Matthews Univ, Dept Pathol, Sch Med, Georgetown, Cayman Islands.
EM samalnauhria@gmail.com
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NR 118
TC 2
Z9 2
U1 3
U2 11
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1087-2981
J9 MED EDUC ONLINE
JI Med. Educ. Online
PD DEC 31
PY 2024
VL 29
IS 1
AR 2364486
DI 10.1080/10872981.2024.2364486
PG 18
WC Education & Educational Research
WE Social Science Citation Index (SSCI)
SC Education & Educational Research
GA TX3Q1
UT WOS:001244522300001
PM 38861675
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Vannoy, SD
   Mauer, B
   Kern, J
   Girn, K
   Ingoglia, C
   Campbell, J
   Galbreath, L
   Unützer, J
AF Vannoy, Steven D.
   Mauer, Barbara
   Kern, John
   Girn, Kamaljeet
   Ingoglia, Charles
   Campbell, Jeannie
   Galbreath, Laura
   Unuetzer, Juergen
TI A Learning Collaborative of CMHCs and CHCs to Support Integration of
   Behavioral Health and General Medical Care
SO PSYCHIATRIC SERVICES
LA English
DT Article
ID MENTAL-HEALTH; VALIDATION; CENTERS; QUESTIONNAIRE; DEPRESSION; SERVICES;
   LESSONS
AB Objective: Integration of general medical and mental health services is a growing priority for safety-net providers. The authors describe a project that established a one-year learning collaborative focused on integration of services between community health centers (CHCs) and community mental health centers (CMHCs). Specific targets were treatment for general medical and psychiatric symptoms related to depression, bipolar disorder, alcohol use disorders, and metabolic syndrome. Methods: This observational study used mixed methods. Quantitative measures included 15 patient-level health indicators, practice self-assessment of resources and support for chronic disease self-management, and participant satisfaction. Results: Sixteen CHC-CMHC pairs were selected for the learning collaborative series. One pair dropped out because of personnel turnover. All teams increased capacity on one or more patient health indicators. CHCs scored higher than CMHCs on support for chronic disease self-management. Participation in the learning collaborative increased self-assessment scores for CHCs and CMHCs. Participant satisfaction was high. Observations by faculty indicate that quality improvement challenges included tracking patient-level outcomes, workforce issues, and cross-agency communication. Conclusions: Even though numerous systemic barriers were encountered, the findings support existing literature indicating that the learning collaborative is a viable quality improvement approach for enhancing integration of general medical and mental health services between CHCs and CMHCs. Real-world implementation of evidence-based guidelines presents challenges often absent in research. Technical resources and support, a stable workforce with adequate training, and adequate opportunities for collaborator communications are particular challenges for integrating behavioral and general medical services across CHCs and CMHCs. (Psychiatric Services 62: 753-758, 2011)
C1 [Vannoy, Steven D.; Unuetzer, Juergen] Univ Washington, Dept Psychiat & Behav Sci, Seattle, WA 98195 USA.
   [Mauer, Barbara] MCPP Healthcare Consulting Inc, Seattle, WA USA.
   [Kern, John] Reg Mental Hlth Ctr, Merrillville, IN USA.
   [Girn, Kamaljeet] NorthShore Hlth Ctr, Portage, IN USA.
   [Ingoglia, Charles; Campbell, Jeannie; Galbreath, Laura] Natl Council Community Behav Healthcare, Washington, DC USA.
C3 University of Washington; University of Washington Seattle
RP Vannoy, SD (corresponding author), Univ Washington, Dept Psychiat & Behav Sci, 1959 NE Pacific St,Box 356560,BB1533, Seattle, WA 98195 USA.
EM svannoy@uw.edu
RI vannoy, steven/W-2737-2019; Unutzer, Jurgen/N-4048-2018
OI Unutzer, Jurgen/0009-0005-6585-7835; Vannoy, Steven/0000-0003-3029-8306
FU National Council
FX Dr. Vannoy, Dr. Unutzer, and Ms. Mauer received payment as faculty
   consultants for this project from the National Council. The other
   authors report no competing interests.
CR [Anonymous], 2003, BREAKTHR SER IHIS CO
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NR 23
TC 27
Z9 32
U1 0
U2 11
PU AMER PSYCHIATRIC PUBLISHING, INC
PI ARLINGTON
PA 1000 WILSON BOULEVARD, STE 1825, ARLINGTON, VA 22209-3901 USA
SN 1075-2730
J9 PSYCHIAT SERV
JI Psychiatr. Serv.
PD JUL
PY 2011
VL 62
IS 7
BP 753
EP 758
PG 6
WC Health Policy & Services; Public, Environmental & Occupational Health;
   Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services; Public, Environmental & Occupational
   Health; Psychiatry
GA 786FG
UT WOS:000292288200011
PM 21724788
OA Bronze
DA 2025-06-11
ER

PT J
AU Zalihic, A
   Markotic, V
   Mabic, M
   Cerni-Obrdalj, E
   Zalihic, D
   Pivic, G
   Ostojic, L
AF Zalihic, Amra
   Markotic, V.
   Mabic, M.
   Cerni-Obrdalj, E.
   Zalihic, D.
   Pivic, G.
   Ostojic, Lj.
TI DIFFERENCES IN QUALITY OF LIFE AFTER STROKE AND MYOCARDIAL INFARCTION
SO PSYCHIATRIA DANUBINA
LA English
DT Article; Proceedings Paper
CT 24th Danube Congress of Psychiatry
CY MAY 05-08, 2010
CL Zagreb, CROATIA
SP Danubian Psychiat Assoc
DE stroke; myocardial infarction; quality of life; depression; anxiety
ID RANDOMIZED CONTROLLED-TRIAL; METABOLIC SYNDROME; DEPRESSIVE SYMPTOMS;
   GENERAL-POPULATION; ISCHEMIC-STROKE; FOLLOW-UP; SURVIVORS; EDUCATION;
   PROGNOSIS; SUPPORT
AB Introduction: There is obvious decline in quality of life after MI and stroke. The main factors that reduce quality of life in these patients were the inability of returning to normal activities, pain and the development of depression / anxiety. We wanted to know what has the biggest influence on recovery and differences in quality of life in patients after stroke and heart attack.
   Subjects and Methods: Cross-sectional study was conducted using HADS and WHO QOL-Bref questionnaire. Criteria for exclusion were diabetes, previous depression, cancer or other co morbidities that influenced the quality of life. It has been surveyed total of 396 patients, of whom 378 patients satisfied the criteria of inclusion in the study Based on the personal data of patients, they were divided according to gender, age, educational level, and social support expressed by number of members with whom patient lives.
   Results: In all the observed parameters of the SU group had better results than the stroke group. The recovery after a stroke affected age, length of education and depression. Age, gender and length of education influence on a heart attack recovery. Disease duration did not affect the quality of life in either group. Significantly more patients after a stroke had depression compared to MI (p<0.001). Anxiety was not found significant in differences between groups (p=0.051). Metabolic syndrome was more frequent in the stroke group, but the difference between groups was not significant (stroke/MI) (p=0.098). In the group of stroke patients who had MS patients more often had depression (p=0.003) for different of respondents from the group with MI.
   Conclusion: Quality of life was significantly worse in patients after stroke compared to those with MI. The recovery from stroke was most significantly impacted by depression and age and level of education, while the recovery from heart attack was at most affected by gender, age and level of education.
C1 [Zalihic, Amra; Markotic, V.; Cerni-Obrdalj, E.; Pivic, G.] Hlth Care Ctr Mostar, Dept Family Med, Mostar, Bosnia & Herceg.
   [Zalihic, Amra; Cerni-Obrdalj, E.; Zalihic, D.; Pivic, G.; Ostojic, Lj.] Univ Mostar, Fac Med, Mostar, Bosnia & Herceg.
   [Mabic, M.] Univ Mostar, Fac Econ, Mostar, Bosnia & Herceg.
C3 University of Mostar; University of Mostar; University of Mostar
RP Zalihic, A (corresponding author), Dr Ante Starcevica 32C, Mostar 88000, Bosnia & Herceg.
EM dia.zalihic@tel.net.ba
RI Ostojic, Ljerka/D-8355-2017; Mabic, Mirela/N-8720-2018
OI Zalihic, Amra/0000-0003-1838-1465; Mabic, Mirela/0000-0002-1529-7797
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NR 35
TC 12
Z9 13
U1 1
U2 6
PU MEDICINSKA NAKLADA
PI ZAGREB
PA VLASKA 69, HR-10000 ZAGREB, CROATIA
SN 0353-5053
J9 PSYCHIAT DANUB
JI Psychiatr. Danub.
PD JUN
PY 2010
VL 22
IS 2
BP 241
EP 248
PG 8
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI); Conference Proceedings Citation Index - Social Science &amp; Humanities (CPCI-SSH); Conference Proceedings Citation Index - Science (CPCI-S)
SC Psychiatry
GA 616JT
UT WOS:000279206200017
PM 20562754
DA 2025-06-11
ER

PT J
AU Tsai, SF
   Wu, HT
   Chen, PC
   Chen, YW
   Yu, MG
   Wang, TF
   Wu, SY
   Tzeng, SF
   Kuo, YM
AF Tsai, Sheng-Feng
   Wu, Hung-Tsung
   Chen, Pei-Chun
   Chen, Yun-Wen
   Yu, Megan
   Wang, Tzu-Feng
   Wu, Shih-Ying
   Tzeng, Shun-Fen
   Kuo, Yu-Min
TI High-fat diet suppresses the astrocytic process arborization and
   downregulates the glial glutamate transporters in the hippocampus of
   mice
SO BRAIN RESEARCH
LA English
DT Article
DE Depression; Obesity; Diabetes; GLAST; GLT-1
ID INSULIN-RESISTANCE; METABOLIC SYNDROME; BRAIN; MEMORY; EXPRESSION;
   LACTATE; ANXIETY; NEUROGENESIS; ACTIVATION; DISORDERS
AB Metabolic disorders induce adverse effects on brain functions. The hippocampus is one of the most vulnerable regions to metabolic disorders. Disrupted neuroplasticity is a major cause of hippocampus-related behavioral impairments, including memory loss, anxiety, and depression. Astrocytes support processes of neuroplasticity. However, whether metabolic disorders induce changes in astrocytes and their roles in affective disorders is relatively unclear. To answer this question, we fed 8-week-old male C57BL/6 mice with a high-fat diet (HFD) for 12 weeks to induce metabolic disruption and then examined their performance of hippocampus-related memory, and anxiety- and depression-like behaviors. The morphology of astrocytes and the expression of astrocytic neuroplasticity-related proteins in the hippocampus were also assessed. The results showed that HFD led to obesity, systemic insulin resistance and dysregulated lipid metabolism in mice. HFD induced depression-like behaviors, but not anxiety or memory impairment. Furthermore, HFD increased the expression of GFAP, shortened the processes of GFAP(+) cells, and downregulated the expression of astrocytic neuroplasticity-related protein, GLAST, GLT-1, and connexin-43 in the hippocampi. In conclusion, HFD disturbs the function of hippocampal astrocytes and induces depression-like behaviors in mice. A decrease of hippocampal glutamate transporters may play a critical role in the pathogenesis of metabolic disorder-related depression. (C) 2018 Elsevier B.V. All rights reserved.
C1 [Tsai, Sheng-Feng; Chen, Pei-Chun; Chen, Yun-Wen; Wu, Shih-Ying; Tzeng, Shun-Fen; Kuo, Yu-Min] Natl Cheng Kung Univ, Inst Basic Med Sci, Coll Med, Tainan, Taiwan.
   [Wu, Hung-Tsung] Natl Cheng Kung Univ, Natl Cheng Kung Univ Hosp, Dept Family Med, Tainan, Taiwan.
   [Chen, Pei-Chun] Natl Cheng Kung Univ, Dept Physiol, Coll Med, Tainan, Taiwan.
   [Chen, Yun-Wen] Natl Cheng Kung Univ, Dept Pharmacol, Coll Med, Tainan, Taiwan.
   [Yu, Megan] Univ Virginia, Dept Chem, Charlottesville, VA USA.
   [Wang, Tzu-Feng] Natl Cheng Kung Univ, Taiwan Int Grad Program Interdisciplinary Neurosc, Taipei, Taiwan.
   [Wang, Tzu-Feng] Acad Sinica, Taipei, Taiwan.
   [Tzeng, Shun-Fen] Natl Cheng Kung Univ, Dept Life Sci, Coll Biosci & Biotechnol, Tainan, Taiwan.
   [Kuo, Yu-Min] Natl Cheng Kung Univ, Dept Cell Biol & Anat, Coll Med, 1 Ta Hsueh Rd, Tainan 70101, Taiwan.
C3 National Cheng Kung University; National Cheng Kung University; National
   Cheng Kung University Hospital; National Cheng Kung University; National
   Cheng Kung University; University of Virginia; National Cheng Kung
   University; Academia Sinica - Taiwan; National Cheng Kung University;
   National Cheng Kung University
RP Kuo, YM (corresponding author), Natl Cheng Kung Univ, Dept Cell Biol & Anat, Coll Med, 1 Ta Hsueh Rd, Tainan 70101, Taiwan.
EM kuoym@mail.ncku.edu.tw
RI Sheng Feng, Tsai/HZM-0540-2023; Chen, Pei-Chun/K-8439-2019; Kuo,
   Yu-Min/A-9050-2013
OI Chen, Pei-Chun/0000-0002-2550-6556; Tsai,
   Sheng-Feng/0000-0001-5800-4280; Kuo, Yu-Min/0000-0003-4867-2482; Yu,
   Megan/0000-0002-7239-4980; Wu, Hung-Tsung/0000-0002-0611-8427
FU Ministry of Science and TechnologyTaiwan [MOST 104-2320-B-006-039-MY3]
FX This work was supported by Ministry of Science and TechnologyTaiwan
   (grant number: MOST 104-2320-B-006-039-MY3).
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NR 61
TC 41
Z9 43
U1 1
U2 24
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0006-8993
EI 1872-6240
J9 BRAIN RES
JI Brain Res.
PD DEC 1
PY 2018
VL 1700
BP 66
EP 77
DI 10.1016/j.brainres.2018.07.017
PG 12
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA HB8PU
UT WOS:000451353600008
PM 30009766
DA 2025-06-11
ER

PT J
AU Black, CN
   Bot, M
   Scheffer, PG
   Snieder, H
   Penninx, BWJH
AF Black, Catherine N.
   Bot, Mariska
   Scheffer, Peter G.
   Snieder, Harold
   Penninx, Brenda W. J. H.
TI Uric acid in major depressive and anxiety disorders
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Major depressive disorder; Anxiety disorder; Uric acid; Antioxidant;
   Oxidative stress
ID BIPOLAR DISORDER; METABOLIC SYNDROME; OXIDATIVE STRESS; PSYCHOMETRIC
   PROPERTIES; METAANALYSIS; ANTIOXIDANT; DISEASE; ALLOPURINOL;
   ASSOCIATION; HYPOTHESIS
AB Background: Uric acid has neuroprotective effects, owing to its antioxidant properties. Lowered antioxidant capacity, causing increased oxidative stress, may be involved in affective disorders and might be altered by antidepressants. This study investigated the association of plasma uric acid, the greatest contributor to blood antioxidant capacity, with major depressive disorder (MDD) and anxiety disorders.
   Methods: Data were from the Netherlands Study of Depression and Anxiety including patients with current (N = 1648), remitted (N = 609) MDD and/or anxiety disorders (of which N = 710 antidepressant users) and 618 controls. Diagnoses were established with the Composite International Diagnostic Interview. Symptom severity was assessed with the Inventory of Depressive Symptoms-Self Report, Beck Anxiety Inventory and Fear Questionnaire. Uric acid was measured in plasma. Analyses were adjusted for sociodemographic, health and lifestyle variables.
   Results: Plasma uric acid adjusted mean levels were lower in current MDD and/or anxiety disorder(s) (289 mu mol/l) compared to remitted disorders (298 mu mol/l, p < .001) and controls (299 mu mol/l, p < .001; Cohen's d.10). This finding was independent of antidepressant use. Depressive (beta-.05, p = .0012), anxiety (beta-.04, p = .009) and phobic (beta-.03, p =. 036) symptom severity, and symptom duration (beta-.04, p =. 009) were negatively associated with uric acid.
   Limitations: Limitations include the lack of data on dietary intake which could be a potential confounding factor. From these cross-sectional findings, the association between uric acid and psychopathology cannot be inferred to be causal.
   Conclusion: This large scale study finds plasma uric acid levels are lower in current, but not remitted, MDD and/or anxiety disorders, according to a dose-response gradient. This suggests the involvement of decreased antioxidant status in affective disorders, and points to their potential as an avenue for treatment.
C1 [Black, Catherine N.; Bot, Mariska; Penninx, Brenda W. J. H.] Vrije Univ Amsterdam, Dept Psychiat, Med Ctr, Postbus 74077, NL-1070 BB Amsterdam, Netherlands.
   [Black, Catherine N.; Bot, Mariska; Penninx, Brenda W. J. H.] Vrije Univ Amsterdam, EMGO Inst Hlth & Care Res, Med Ctr, Amsterdam, Netherlands.
   [Black, Catherine N.; Bot, Mariska; Penninx, Brenda W. J. H.] GGZ inGeest, Amsterdam, Netherlands.
   [Scheffer, Peter G.] Vrije Univ Amsterdam, Dept Clin Chem, Med Ctr, Amsterdam, Netherlands.
   [Snieder, Harold] Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, Groningen, Netherlands.
C3 Vrije Universiteit Amsterdam; Vrije Universiteit Amsterdam; Vrije
   Universiteit Amsterdam; University of Groningen
RP Black, CN (corresponding author), Vrije Univ Amsterdam, Dept Psychiat, Med Ctr, Postbus 74077, NL-1070 BB Amsterdam, Netherlands.
EM c.black@ggzingeest.nl
RI Penninx, Brenda/S-7627-2017
FU Geestkracht program of the Netherlands Organization for Health Research
   and Development (Zon-Mw) [10-000-1002]; VU University Medical Center;
   Leiden University Medical Center; University Medical Center Groningen;
   NWO-VICI grant [91811602]
FX The infrastructure for the NESDA study (www.nesda.nl) has been funded
   through the Geestkracht program of the Netherlands Organization for
   Health Research and Development (Zon-Mw, grant number 10-000-1002) and
   participating universities (VU University Medical Center, Leiden
   University Medical Center, University Medical Center Groningen).
   Catherine N. Black and Brenda W.J.H. Penninx are supported through a
   NWO-VICI grant (number 91811602). The grant providers had no involvement
   in the study design; in the data collection, analysis or interpretation
   of data; in the writing of the report; or in the decision to submit the
   article for publication.
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NR 46
TC 79
Z9 86
U1 3
U2 40
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD JAN 1
PY 2018
VL 225
BP 684
EP 690
DI 10.1016/j.jad.2017.09.003
PG 7
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA FK3SF
UT WOS:000413405700096
PM 28917195
OA Green Published
DA 2025-06-11
ER

PT J
AU Abdalla-Aslan, R
   Findler, M
   Zini, A
   Almoznino, G
AF Abdalla-Aslan, Ragda
   Findler, Mordechai
   Zini, Avraham
   Almoznino, Galit
TI Caries experience, periodontal status, and metabolic morbidity in
   patients with psychiatric disorders
SO QUINTESSENCE INTERNATIONAL
LA English
DT Article
DE psychiatric disorders; dental caries; plaque score; risk factor;
   smoking; metabolic syndrome; diabetes; hypertension; hyperlipidemia
ID LOW BLOOD-PRESSURE; POOR ORAL-HEALTH; DENTAL-CARIES; RISK-FACTORS;
   LIFE-STYLE; CARDIOMETABOLIC RISK; BIPOLAR DISORDER; DEPRESSION; ANXIETY;
   ASSOCIATION
AB Objectives: To investigate the association of psychiatric disorders with (1) caries experience, (2) periodontal status, and (3) metabolic syndrome (MetS) components. Method and materials: This 7-year cross-sectional study retrospectively analyzed the medical records of 504 individuals aged 18 to 90 years who attended the student dental clinic. Collected data included: demographics, smoking habits, systolic and diastolic blood pressures, pulse, waist circumference, full-mouth plaque score (FMPS), full-mouth bleeding score (FMBS), maximal pocket probing depth (PPD), average and maximal radiographic bone loss (RBL), the sum of the number of decayed (D), missing (M), and filled (F) teeth (DMFT score), and presence of MetS components, consequences and related conditions including diabetes, hypertension, hyperlipidemia, ischemic heart disease, heart failure, s/p stroke, and cancer. Results: 68 (13.5%) had psychiatric disorders with an average age of 53.42 +/- 15.71 years. Psychiatric disorders were positively associated with smoking (P =.008), smoking pack-years (P =.004), DMFT score (P =.005), and negatively associated with hypertension (P =.046). Psychiatric disorders had no statistically significant associations with all periodontal indices studied and with other components of MetS. Following multivariate analysis, psychiatric disorders retained a statistically significant positive association with smoking (odds ratio [OR] and 95% confidence interval [CI] = 2.24 [1.28 to 3.92]) and with DMFT (OR and 95% CI = 1.08 [1.02 to 1.14]), and a statistically significant negative association with hypertension (OR and 95% CI = 0.46 [0.25 to 0.84]). Conclusions: Psychiatric disorders were positively associated with smoking and caries experience but not with periodontal status and metabolic morbidity. Communication between dental and medical professionals is needed to address the higher smoking consumption and caries morbidity in psychiatric patients.
C1 [Abdalla-Aslan, Ragda] Hebrew Univ Jerusalem Hadassah Hosp & Med Sch, Dept Oral Med Sedat & Maxillofacial Imaging, Sch Dent Med, Jerusalem, Israel.
   [Findler, Mordechai] Chaim Sheba Med Ctr, Oral Med Unit, Ramat Gan, Israel.
   [Zini, Avraham] Hebrew Univ Jerusalem, Dept Community Dent, Hadassah Sch Dent Med, Jerusalem, Israel.
   [Almoznino, Galit] Hebrew Univ Jerusalem Hadassah Hosp & Med Sch, Big Biomed Data Res Lab, Sch Dent Med, POB 12272, IL-91120 Jerusalem, Israel.
   [Almoznino, Galit] Hebrew Univ Jerusalem Hadassah Hosp & Med Sch, Dept Endodont, Sch Dent Med, POB 12272, IL-91120 Jerusalem, Israel.
   [Almoznino, Galit] Hebrew Univ Jerusalem Hadassah Hosp & Med Sch, Dept Oral Med Sedat & Maxillofacial Imaging, Fac Dent Med,Sch Dent Med, Orofacial Sensory Taste & Smell Clin, POB 12272, IL-91120 Jerusalem, Israel.
C3 Hebrew University of Jerusalem; Hadassah University Hospital; Hadassah
   University Medical Center; Chaim Sheba Medical Center; Hebrew University
   of Jerusalem; Hebrew University of Jerusalem; Hadassah University
   Hospital; Hadassah University Medical Center; Hebrew University of
   Jerusalem; Hadassah University Hospital; Hadassah University Medical
   Center; Hebrew University of Jerusalem; Hadassah University Hospital;
   Hadassah University Medical Center
RP Almoznino, G (corresponding author), Hebrew Univ Jerusalem Hadassah Hosp & Med Sch, Big Biomed Data Res Lab, Sch Dent Med, POB 12272, IL-91120 Jerusalem, Israel.; Almoznino, G (corresponding author), Hebrew Univ Jerusalem Hadassah Hosp & Med Sch, Dept Endodont, Sch Dent Med, POB 12272, IL-91120 Jerusalem, Israel.; Almoznino, G (corresponding author), Hebrew Univ Jerusalem Hadassah Hosp & Med Sch, Dept Oral Med Sedat & Maxillofacial Imaging, Fac Dent Med,Sch Dent Med, Orofacial Sensory Taste & Smell Clin, POB 12272, IL-91120 Jerusalem, Israel.
EM galit@almoznino.com
OI Almoznino, Galit/0000-0001-9671-0047
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NR 57
TC 2
Z9 2
U1 0
U2 7
PU QUINTESSENCE PUBLISHING CO INC
PI HANOVER PARK
PA 4350 CHANDLER DRIVE, HANOVER PARK, IL 60133 USA
SN 0033-6572
EI 1936-7163
J9 QUINTESSENCE INT
JI Quintessence Int.
PD JUN
PY 2021
VL 52
IS 6
BP 516
EP 526
AR PMID 33688712
DI 10.3290/j.qi.b1044091
PG 11
WC Dentistry, Oral Surgery & Medicine
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dentistry, Oral Surgery & Medicine
GA SE6GX
UT WOS:000652169900006
PM 33688712
DA 2025-06-11
ER

PT J
AU Shara, NM
   Zeymo, A
   Abudiab, Z
   Umans, JG
   Abu-Bader, S
   Getaneh, A
   Howard, BV
AF Shara, Nawar M.
   Zeymo, Alexander
   Abudiab, Zeid
   Umans, Jason G.
   Abu-Bader, Soleman
   Getaneh, Asqual
   Howard, Barbara V.
TI Depression, Metabolic Syndrome, and Locus of Control in Arab Americans
   Living in the DC Metropolitan Area: A Structural Equation Model
SO JOURNAL OF IMMIGRANT AND MINORITY HEALTH
LA English
DT Article
DE Arab Americans; Depression; Locus of control; Metabolic syndrome; SEM
ID MULTIDIMENSIONAL HEALTH LOCUS; CORONARY-HEART-DISEASE; PREVALENCE;
   COMORBIDITY
AB Arab Americans have high prevalences of metabolic syndrome (MetS) and depression. Depression and external locus of control (LOC) may worsen MetS. We examined the relationship between depression and MetS with a convenience sample of 136 Arab Americans living in the Washington, DC, metropolitan area. Participants were surveyed with the Multidimensional Health Locus of Control questionnaire and the Center of Epidemiological Studies-Depression scale. Laboratory measurements were collected based on the components of MetS. A structural equation model was used to explore the relationship between MetS and depression through analysis of LOC. MetS was significantly correlated with external LOC (powerful others and chance), and depression was correlated with a weak internal LOC. Future study of the effect of LOC on health outcomes in Arab Americans may be used to mitigate MetS and depression in this population.
C1 [Shara, Nawar M.; Zeymo, Alexander; Abudiab, Zeid; Umans, Jason G.; Getaneh, Asqual; Howard, Barbara V.] MedStar Hlth Res Inst, 6525 Belcrest Rd,Suite 700, Hyattsville, MD 20782 USA.
   [Shara, Nawar M.; Umans, Jason G.; Howard, Barbara V.] Georgetown Howard Univ Ctr Clin & Translat Sci, Washington, DC USA.
   [Abu-Bader, Soleman] Howard Univ, Washington, DC 20059 USA.
C3 MedStar Health Research Institute; Howard University
RP Shara, NM (corresponding author), MedStar Hlth Res Inst, 6525 Belcrest Rd,Suite 700, Hyattsville, MD 20782 USA.; Shara, NM (corresponding author), Georgetown Howard Univ Ctr Clin & Translat Sci, Washington, DC USA.
EM Nawar.Shara@MedStar.net
FU National Center for Advancing Translational Sciences of the National
   Institutes of Health [UL1TR001409]
FX This research was funded by the National Center for Advancing
   Translational Sciences of the National Institutes of Health (Award
   Number UL1TR001409).
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NR 47
TC 3
Z9 5
U1 0
U2 6
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1557-1912
EI 1557-1920
J9 J IMMIGR MINOR HEALT
JI J. Immigr. Minor. Health
PD AUG
PY 2018
VL 20
IS 4
BP 902
EP 908
DI 10.1007/s10903-017-0626-0
PG 7
WC Public, Environmental & Occupational Health
WE Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA GM0NY
UT WOS:000437750800018
PM 28744602
OA Green Accepted
DA 2025-06-11
ER

PT J
AU LaValle, JB
AF LaValle, JB
TI Hidden disruptions in metabolic syndrome: Drug-induced nutrient
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LA English
DT Article
ID INSULIN-RESISTANCE; MAGNESIUM-DEFICIENCY; COENZYME Q(10); HOMOCYSTEINE;
   MELATONIN; SLEEP; FOLATE; VITAMIN-B-12; DEPRESSION; DURATION
C1 Living Longer Inst, Cincinnati, OH USA.
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RP Living Longer Inst, Cincinnati, OH USA.
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NR 40
TC 6
Z9 6
U1 0
U2 2
PU INNOVISION COMMUNICATIONS
PI ALISO VIEJO
PA 101 COLUMBIA, ALISO VIEJO, CA 92656 USA
SN 1078-6791
J9 ALTERN THER HEALTH M
JI Altern. Ther. Health Med.
PD MAR-APR
PY 2006
VL 12
IS 2
BP 26
EP 31
PG 6
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA 021YF
UT WOS:000236021100004
PM 16541994
DA 2025-06-11
ER

PT J
AU Du, D
   Bruno, R
   Dwyer, T
   Venn, A
   Gall, S
AF Du, Duc
   Bruno, Raimondo
   Dwyer, Terry
   Venn, Alison
   Gall, Seana
TI Associations between alcohol consumption and cardio-metabolic risk
   factors in young adults
SO EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
LA English
DT Article
DE Cardio-metabolic risk factors; metabolic syndrome; alcohol consumption;
   epidemiology; lifestyle; cardiovascular diseases
ID BLOOD-PRESSURE; CARDIOVASCULAR RISK; PHYSICAL-ACTIVITY; METAANALYSIS;
   HEALTH; PREVALENCE; MORTALITY; SMOKING; DETERMINANTS; DRINKERS
AB Introduction The benefits of alcohol consumption for cardiovascular and metabolic health may have been overstated due to inappropriate comparisons with abstainers and inadequate control for confounding factors including physical activity and mental health. We examined alcohol consumption and cardio-metabolic health in a cohort of young Australian adults overcoming these limitations.
   Methods Cross-sectional data of a cohort of 2200 participants (age range 25-36 years) from the 2004-06 Childhood Determinants of Adult Health were used. Alcohol consumption was assessed from questionnaire and cardio-metabolic risk factors were measured in clinics. Linear and log binomial regression were used to examine total alcohol consumption (categories: none 0g/day; light >0-10g/day [reference]; moderate >10-20g/day; heavy >20-30g/day; very heavy >30g/day) against dichotomous metabolic syndrome and its components: waist circumference, triglycerides, high-density lipoprotein cholesterol, blood pressure and glucose. Covariates included socio-demographics, smoking, diet, physical activity, fitness, depression and anxiety.
   Results Of the 2220 participants (48% males, mean (standard deviation) age 29.5 (2.5) years), most were classified in the light drinking' group (54.2%), less were in the non-drinking' (13.2%), heavy' (5.2%) or very heavy' (5.5%) drinking groups. Only moderate drinking was associated with a significantly lower prevalence of metabolic syndrome (prevalence ratio=0.64, p<0.05) compared with light drinking. Higher levels of alcohol consumption were associated with higher high-density lipoprotein cholesterol (=0.05, p(trend)<0.001). Very heavy compared to light drinkers had higher systolic (=3.01mm Hg, p<0.01) and diastolic (=2.07mm Hg, p<0.05) blood pressure.
   Conclusion Moderate alcohol consumption was associated with a lower prevalence of MetS, and more favourable levels of lipids but not glucose or blood pressure even when compared to light consumption and with account for a range of confounding factors.
C1 [Du, Duc; Dwyer, Terry; Venn, Alison; Gall, Seana] Univ Tasmania, Menzies Inst Med Res, Private Bag 23, Hobart, Tas 7001, Australia.
   [Bruno, Raimondo] Univ Tasmania, Sch Med, Hobart, Tas, Australia.
C3 University of Tasmania; Menzies Institute for Medical Research;
   University of Tasmania
RP Gall, S (corresponding author), Univ Tasmania, Menzies Inst Med Res, Private Bag 23, Hobart, Tas 7001, Australia.
EM Seana.Gall@utas.edu.au
RI Venn, Alison/J-2803-2013; Bruno, Raimondo/A-2381-2009; Gall,
   Seana/B-6585-2013; Du, Duc/O-3890-2015
OI Bruno, Raimondo/0000-0001-6673-833X; Gall, Seana/0000-0002-5138-2526;
   Du, Duc/0000-0002-9181-3386
FU National Health and Medical Research Council [211316]; National Heart
   Foundation [GOOH 0578, PH 11H 6047, FLF 100446]; Menzies Vietnamese
   Scholarship
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: This study
   was supported by the National Health and Medical Research Council
   (Project Grant 211316, Senior Research Fellowship to AV); the National
   Heart Foundation (Project Grant GOOH 0578, Fellowships PH 11H 6047 and
   FLF 100446 to SG). DD was supported by a Menzies Vietnamese Scholarship.
   The study was approved by the Tasmanian Health and Medical Human
   Research Ethics Committee.
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NR 43
TC 20
Z9 20
U1 0
U2 7
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 2047-4873
EI 2047-4881
J9 EUR J PREV CARDIOL
JI Eur. J. Prev. Cardiol.
PD DEC
PY 2017
VL 24
IS 18
BP 1967
EP 1978
DI 10.1177/2047487317724008
PG 12
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Cardiovascular System & Cardiology
GA FN4WO
UT WOS:000416007600009
PM 28762751
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Lamounier-Zepter, V
   Ehrhart-Bornstein, M
   Bornstein, SR
AF Lamounier-Zepter, V.
   Ehrhart-Bornstein, M.
   Bornstein, S. R.
TI Metabolic syndrome and the endocrine stress system
SO HORMONE AND METABOLIC RESEARCH
LA English
DT Review
DE obesity; metabolic syndrome; stress; hypothalamic-pituitary-adrenal axis
ID PITUITARY-ADRENAL AXIS; MESSENGER-RIBONUCLEIC-ACID; PLASMA LEPTIN
   LEVELS; CORTISOL SECRETION; HORMONE RECEPTORS; ABDOMINAL OBESITY; FAT
   DISTRIBUTION; PREVALENCE; INSULIN; ADIPOCYTES
AB Obesity constitutes one of the most serious public health problems, with rapidly increasing prevalence in western societies. Consequently, metabolic syndrome, a condition strongly associated with obesity, has become an epidemic problem. Recent studies have implicated chronic alterations to the stress system as playing a major role in the metabolic syndrome's pathophys-iology. This brief review discusses the role of stress and hypothalamic-pituitary-adrenal axis dysfunction in the development of metabolic syndrome as well as new insights into the crosstalk between adipose tissue and endocrine stress system.
C1 Tech Univ Dresden, Med Clin 3, MTZ, D-01307 Dresden, Germany.
C3 Technische Universitat Dresden
RP Lamounier-Zepter, V (corresponding author), Tech Univ Dresden, Med Clin 3, MTZ, Room B-00-002,Fetscherstr 74, D-01307 Dresden, Germany.
EM valeria.zepter@uniklinikum-dresden.de
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NR 48
TC 31
Z9 34
U1 1
U2 7
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0018-5043
EI 1439-4286
J9 HORM METAB RES
JI Horm. Metab. Res.
PD JUL
PY 2006
VL 38
IS 7
BP 437
EP 441
DI 10.1055/s-2006-947837
PG 5
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 080FD
UT WOS:000240232400002
PM 16933178
DA 2025-06-11
ER

PT J
AU Cleary, A
   Walsh, F
   Connolly, H
   Hays, V
   Oluwole, B
   Macken, E
   Dowling, M
AF Cleary, A.
   Walsh, F.
   Connolly, H.
   Hays, V.
   Oluwole, B.
   Macken, E.
   Dowling, M.
TI Monitoring and documentation of side effects from depot antipsychotic
   medication: an interdisciplinary audit of practice in a regional mental
   health service
SO JOURNAL OF PSYCHIATRIC AND MENTAL HEALTH NURSING
LA English
DT Article
DE antipsychotics; audit; depot; mental health; metabolic syndrome; side
   effects
ID SCHIZOPHRENIA; PEOPLE; NURSE
AB This audit reviewed current practice within a rural mental health service area on the monitoring and documentation of side effects of antipsychotic depot medication. A sample of 60 case files, care plans and prescriptions were audited, which is 31% of the total number of service users receiving depot injections in the mental health service region (n= 181). The sample audited had a range of diagnoses, including: schizophrenia, schizoaffective disorder, bipolar affective disorder, depression, alcoholic hallucinosis and autism. The audit results revealed that most service users had an annual documented medical review and a documented prescription. However, only five (8%) case notes examined had documentation recorded describing the condition of the injection site, and alternation of the injection site was recorded in only 28 (47%) case notes. No case notes examined had written consent to commence treatment recorded. In 57 (95%) of case notes, no documentation of recorded information on the depot and on side effects was given. The failure to monitor and record some blood tests was partly attributed to a lack of clarity regarding whose responsibility it was. A standardized checklist has been developed as a result of the audit and this will be introduced by all teams across the service.
C1 [Cleary, A.; Connolly, H.] St Brigids Hosp, E Galway Catchment Galway Mental Hlth Serv, Intellectual Disabil Serv, Ballinasloe, Co Galway, Ireland.
   [Dowling, M.] Natl Univ Ireland, Sch Nursing & Midwifery, Galway, Ireland.
C3 Ollscoil na Gaillimhe-University of Galway
RP Cleary, A (corresponding author), St Brigids Hosp, E Galway Catchment Galway Mental Hlth Serv, Intellectual Disabil Serv, Ballinasloe, Co Galway, Ireland.
EM anneg.cleary@hse.ie
RI Dowling, Maura/AAF-4797-2021
OI Dowling, Maura/0000-0002-7832-6276
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NR 36
TC 10
Z9 10
U1 0
U2 10
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1351-0126
EI 1365-2850
J9 J PSYCHIATR MENT HLT
JI J. Psychiatr. Ment. Health Nurs.
PD JUN
PY 2012
VL 19
IS 5
BP 395
EP 401
DI 10.1111/j.1365-2850.2011.01807.x
PG 7
WC Nursing; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Psychiatry
GA 934KC
UT WOS:000303442000004
PM 22070791
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Li, SJ
   Liu, CH
   Chu, HP
   Mersmann, HJ
   Ding, ST
   Chu, CH
   Wang, CY
   Chen, CY
AF Li, Sin-Jin
   Liu, Chia-Hsin
   Chu, Hsien-Pin
   Mersmann, Harry J.
   Ding, Shih-Torng
   Chu, Chun-Han
   Wang, Chia-Yu
   Chen, Ching-Yi
TI The high-fat diet induces myocardial fibrosis in the metabolically
   healthy obese minipigs-The role of ER stress and oxidative stress
SO CLINICAL NUTRITION
LA English
DT Article
DE Metabolic syndrome; Metabolically healthy obesity; Autophagy; ER stress;
   Oxidative stress; Cardiomyopathy
ID COLONY-STIMULATING FACTOR; ENDOPLASMIC-RETICULUM STRESS; HEART-FAILURE;
   CARDIOVASCULAR-DISEASE; CARDIOMETABOLIC RISK; PULMONARY-FIBROSIS;
   INFARCTION; MICE; CELLS; STEATOHEPATITIS
AB Background: The cellular mechanisms of obesity-induced cardiomyopathy are multiple and not completely elucidated. The objective of this study was to differentiate two obesity-associated cardiomyopathy miniature pig models: one with the metabolic syndrome (MetS), and one with a metabolically healthy obesity (MHO). The cellular responses during the development of obesity-induced cardiomyopathy were investigated.
   Methods: Five-month-old Lee-Sung (MetS) and Lanyu (MHO) minipigs were made obese by feeding a high-fat diet (HFD) for 6 months.
   Results: Obese pigs exhibited a greater heart weight than control pigs. Interstitial and perivascular fibrosis developed in the myocardium of obese pigs. The HFD induced cardiac lipid accumulation and oxidative stress and also decreased the antioxidant defense in MetS pigs. This diet activated oxidative stress without changing cardiac antioxidant defense and lipid content in MHO pigs. The HFD upregulated the expression of Grp94, CHOP, caspase 12, p62, and LC3II and increased the ratio of LC3II to LC3I in the left ventricle (LV) of MetS pigs. Compared to obese MetS pigs, less Grp94 and elevated CHOP expression was found in the obese MHO heart. The HFD did not change the ratio of LC3II to LC3I and p62 expression in obese MHO pigs. The obese MetS pigs had an extensive and greater inflammatory response in the plasma than the obese MHO pigs, which had a lesser and milder inflammation.
   Conclusion: Oxidative stress and ER stress were involved in the progression of MHO-related cardiomyopathy. Inflammation, autophagy, ER stress, oxidative stress, and lipotoxicity participated in the pathological mechanism of MetS-related cardiomyopathy. (C) 2016 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.
C1 [Li, Sin-Jin; Liu, Chia-Hsin; Mersmann, Harry J.; Ding, Shih-Torng; Chu, Chun-Han; Wang, Chia-Yu; Chen, Ching-Yi] Natl Taiwan Univ, Dept Anim Sci & Technol, 50,Lane 155,Sec 3,Keelung Rd, Taipei 10672, Taiwan.
   [Chu, Hsien-Pin] Livestock Res Inst Council Agr, Taitung Anim Propagat Stn, 30 Binlang Vil, Beinan Township 95444, Taitung County, Taiwan.
C3 National Taiwan University
RP Chen, CY (corresponding author), Natl Taiwan Univ, Dept Anim Sci & Technol, 50,Lane 155,Sec 3,Keelung Rd, Taipei 10672, Taiwan.
EM ronichen@ntu.edu.tw
RI Liu, Chun-Yu/I-4358-2015
OI Chen, Ching-Yi/0000-0002-5776-084X; Li, Sin-Jin/0000-0002-0010-8439
FU Ministry of Science and Technology [MOST 104-2313-B-002-038-MY3];
   National Taiwan University [NTU-CESRP-104R7615-3]
FX This work was supported by the Research Grant MOST
   104-2313-B-002-038-MY3 (from Ministry of Science and Technology) and
   NTU-CESRP-104R7615-3 (from National Taiwan University). The authors are
   grateful to Dr. Yan-Nian Jiang for his statistical assistance, and Mr.
   Chi-Hui Chen for his technical assistance.
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   Yogo Y, 2009, RESP RES, V10, DOI 10.1186/1465-9921-10-80
   Zweifel M, 2010, TRANSPL P, V42, P2763, DOI 10.1016/j.transproceed.2010.05.152
NR 35
TC 28
Z9 31
U1 1
U2 23
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0261-5614
EI 1532-1983
J9 CLIN NUTR
JI Clin. Nutr.
PD JUN
PY 2017
VL 36
IS 3
BP 760
EP 767
DI 10.1016/j.clnu.2016.06.002
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA EU7IO
UT WOS:000401208700015
PM 27342749
DA 2025-06-11
ER

PT J
AU Veloso, IC
   Delanogare, E
   Machado, AE
   Braga, SP
   Rosa, GK
   De Bem, AF
   Rafique, J
   Saba, S
   da Trindade, RN
   Galetto, FZ
   Moreira, ELG
AF Veloso, Izolene Correa
   Delanogare, Eslen
   Machado, Adriano Emanuel
   Braga, Sara Pereira
   Rosa, Giovana Karoline
   De Bem, Andreza Fabro
   Rafique, Jamal
   Saba, Sumbal
   da Trindade, Roberth Nascimento
   Galetto, Fabio Zazyki
   Gasnhar Moreira, Eduardo Luiz
TI A selanylimidazopyridine (3-SePh-IP) reverses the prodepressant- and
   anxiogenic-like effects of a high-fat/high-fructose diet in mice
SO JOURNAL OF PHARMACY AND PHARMACOLOGY
LA English
DT Article
DE imidazopyridine; selenium; behavioural; obesity
ID HIGH-FAT DIET; CEREBRAL MITOCHONDRIAL DYSFUNCTION; OXIDATIVE STRESS;
   METABOLIC SYNDROME; OBESITY; DEPRESSION; ANXIETY; RISK; PHARMACOLOGY;
   METAANALYSIS
AB Objective While chronic feeding with high-fat or high-sugar diets is known related to obesity and type 2 diabetes, later data have indicated that it is also related to depression and anxiety appearance. In this regard, multi-target drugs raise considerable interest as promising therapeutic solutions to complex diseases. Considering the pharmacological effects of the imidazopyridine-derivative moiety imidazo[1,2-a]pyridine and the organoselenium molecules, the combination of both could be a feasible strategy to develop efficient drugs to handle obesity and related comorbidities, for example dyslipidemia and mood disorders.
   Methods The antidepressant- and anxiolytic-like properties of a selanylimidazopyridine compound, 2-Phenyl-3-(phenylselanyl)imidazo[1,2-a]pyridine (3-SePh-IP), were evaluated on high-fat/high-fructose diet (HFFD)-fed female Swiss mice.
   Key findings Our results showed that a short-term HFFD (16 days) could promote a significant body weight gain, hypercholesterolemia, glucose intolerance, and anxiety- and depressive-like behaviour in mice. Concomitant treatment with 3-SePh-IP (10 mg/kg; i.p.) attenuated the HFFD-induced increase in cholesterol levels and blunted the anxiety- and depressive-like behaviour in mice.
   Conclusions 3-SePh-IP holds multimodal pharmacological properties, which provide a rationale for further studies, for example to assess the underlying mechanisms linked to its anxiolytic- and antidepressive-like activities.
C1 [Rosa, Giovana Karoline; Gasnhar Moreira, Eduardo Luiz] Univ Fed Santa Catarina, Dept Ciencias Fisiol, BR-88040900 Florianopolis, SC, Brazil.
   [Veloso, Izolene Correa; Delanogare, Eslen; Machado, Adriano Emanuel; Gasnhar Moreira, Eduardo Luiz] Univ Fed Santa Catarina, Programa Posgrad Neurociencias, Florianopolis, SC, Brazil.
   [Braga, Sara Pereira; Gasnhar Moreira, Eduardo Luiz] Univ Fed Santa Catarina, Programa Posgrad Multictr Ciencias Fisiol, Florianopolis, SC, Brazil.
   [da Trindade, Roberth Nascimento; Galetto, Fabio Zazyki] Univ Fed Santa Catarina, Dept Quim, Florianopolis, SC, Brazil.
   [De Bem, Andreza Fabro] Univ Brasilia, Inst Ciencias Biol, Dept Ciencias Fisiol, Brasilia, DF, Brazil.
   [Rafique, Jamal] Univ Fed Mato Grosso do Sul, Inst Quim, Campo Grande, MS, Brazil.
   [Saba, Sumbal] Univ Fed ABC, Ctr Ciencias Nat & Humanas CCNH, Santo Andre, SP, Brazil.
C3 Universidade Federal de Santa Catarina (UFSC); Universidade Federal de
   Santa Catarina (UFSC); Universidade Federal de Santa Catarina (UFSC);
   Universidade Federal de Santa Catarina (UFSC); Universidade de Brasilia;
   Universidade Federal de Mato Grosso do Sul; Universidade Federal do ABC
   (UFABC)
RP Moreira, ELG (corresponding author), Univ Fed Santa Catarina, Dept Ciencias Fisiol, BR-88040900 Florianopolis, SC, Brazil.
EM eduardo.luiz@ufsc.br
RI Moreira, Eduardo/N-6420-2014; Trindade, Roberth/HKV-2952-2023; Galetto,
   Fabio/K-3047-2012; de, Andreza/AAA-1523-2019; Machado,
   Adriano/KHE-3669-2024; Gasnhar Moreira, Eduardo Luiz/S-6205-2016; Saba,
   Sumbal/G-1094-2017; Trindade, Roberth/D-2800-2015; Rafique,
   Jamal/I-1459-2012
OI Gasnhar Moreira, Eduardo Luiz/0000-0003-2306-2207; Saba,
   Sumbal/0000-0002-6134-7249; Trindade, Roberth/0000-0002-0748-7013;
   Rafique, Jamal/0000-0002-2336-040X; Machado,
   Adriano/0000-0003-2305-1639; Fabro de Bem, Andreza/0000-0003-1090-5244
FU Brazilian Council for Scientific and Technological (CNPq)
   [424799/2018-9]; CAPES; CNPq
FX This research was funded by the Brazilian Council for Scientific and
   Technological (CNPq) under Grant Number Universal 424799/2018-9. ICV,
   ED, AEM and SPB received scholarships from CAPES, and GKR received a
   scholarship from CNPq.
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NR 67
TC 27
Z9 27
U1 0
U2 12
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0022-3573
EI 2042-7158
J9 J PHARM PHARMACOL
JI J. Pharm. Pharmacol.
PD MAR 27
PY 2021
VL 73
IS 5
BP 673
EP 681
DI 10.1093/jpp/rgaa070
EA MAR 2021
PG 9
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA RJ9QT
UT WOS:000637939900008
PM 33772293
DA 2025-06-11
ER

PT J
AU Skalicky, J
   Muzakova, V
   Kandar, R
   Meloun, M
   Rousar, T
   Palicka, V
AF Skalicky, Jiri
   Muzakova, Vladimira
   Kandar, Roman
   Meloun, Milan
   Rousar, Tomas
   Palicka, Vladimir
TI Evaluation of oxidative stress and inflammation in obese adults with
   metabolic syndrome
SO CLINICAL CHEMISTRY AND LABORATORY MEDICINE
LA English
DT Article
DE inflammation; metabolic syndrome; oxidative stress
ID CARDIOVASCULAR-DISEASE; MYOCARDIAL-INFARCTION; NATIONAL-HEALTH; OXIDIZED
   LDL; MORTALITY; ACTIVATION; PLASMA; RISK; PATHWAY; MARKERS
AB Background: Obesity and metabolic syndrome increase the risk of cardiovascular morbidity and mortality. Oxidative stress seems to be involved in the pathophysiology of diabetes and cardiovascular complications of metabolic syndrome. The aim of our study was to evaluate the level of oxidative stress and inflammation in obese adults with and without metabolic syndrome.
   Methods: Oxidative stress and inflammation markers (total amount of free radicals, malondialdehyde, allantoin, alpha(1)-antiproteinase, oxidized/reduced glutathione ratio, high-sensitive C-reactive protein, fibrinogen), total antioxidant capacity and lipid standardized a-tocopherol were determined in obese subjects fulfilling at least three criteria of metabolic syndrome according to the National Cholesterol Education Program-Adult Treatment Panel III guidelines (n=20 patients), in obese subjects without metabolic syndrome (n=20 patients) and in 48 healthy controls.
   Results: Oxidative stress and inflammation markers were significantly elevated in the obese subjects, especially in those exhibiting metabolic syndrome. According to multidimensional statistical analysis, oxidative stress was independently related to triacylglyceride concentration, abdominal fat, low high-density lipoprotein cholesterol and low lipid standardized alpha-tocopherol in the patients with metabolic syndrome.
   Conclusions: High levels of free radicals together with low antioxidant capacity detected in obese adults indicate elevated oxidative stress, which is - together with systemic inflammation - further potentiated in the case of obese patients with metabolic syndrome. This imbalance in oxidative/antioxidative status and subclinical inflammatory state leads to higher risk of atherosclerotic and diabetic complications.
C1 [Muzakova, Vladimira; Kandar, Roman; Rousar, Tomas] Univ Pardubice, Dept Biol & Biochem Sci, Fac Chem Technol, Pardubice 53203, Czech Republic.
   [Skalicky, Jiri] Reg Hosp Pardubice, Dept Clin Biochem & Diagnost, Pardubice, Czech Republic.
   [Meloun, Milan] Univ Pardubice, Dept Analyt Chem, Fac Chem Technol, Pardubice 53203, Czech Republic.
   [Palicka, Vladimir] Univ Hosp, Inst Clin Biochem & Diagnost, Hradec Kralove, Czech Republic.
C3 University of Pardubice; University of Pardubice; University Hospital
   Hradec Kralove
RP Muzakova, V (corresponding author), Univ Pardubice, Dept Biol & Biochem Sci, Fac Chem Technol, Strossova 239, Pardubice 53203, Czech Republic.
EM vladimira.muzakova@upce.cz
RI Rousar, Tomas/AAV-6341-2021; Palicka, Vladimir/N-1802-2017
OI Rousar, Tomas/0000-0002-6893-821X; Palicka, Vladimir/0000-0001-7236-1647
CR [Anonymous], BLOOD, DOI DOI 10.1001/JAMA.285.19.2486
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NR 40
TC 96
Z9 109
U1 0
U2 21
PU WALTER DE GRUYTER GMBH
PI BERLIN
PA GENTHINER STRASSE 13, D-10785 BERLIN, GERMANY
SN 1434-6621
EI 1437-4331
J9 CLIN CHEM LAB MED
JI Clin. Chem. Lab. Med.
PY 2008
VL 46
IS 4
BP 499
EP 505
DI 10.1515/CCLM.2008.096
PG 7
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA 296CZ
UT WOS:000255522400015
PM 18298345
DA 2025-06-11
ER

PT J
AU Rocha, NG
   Sales, ARK
   Miranda, RL
   Silva, MS
   Silva, JFR
   Silva, BM
   Santos, AA
   Nóobrega, ACL
AF Rocha, Natalia G.
   Sales, Allan R. K.
   Miranda, Renan L.
   Silva, Mayra S.
   Silva, Jemima F. R.
   Silva, Bruno M.
   Santos, Aline A.
   Nobrega, Antonio C. L.
TI Aerobic exercise modulation of mental stress-induced responses in
   cultured endothelial progenitor cells from healthy and metabolic
   syndrome subjects
SO LIFE SCIENCES
LA English
DT Article
DE Cardiometabolic risk; Culture; Exercise; Progenitor cells; Stress
ID BLOOD-PRESSURE RESPONSE; FLOW-MEDIATED DILATION; OXIDATIVE STRESS;
   CARDIOVASCULAR EVENTS; INFLAMMATORY MARKERS; DYSFUNCTION; RISK;
   MECHANISMS; PREVENTS; NUMBER
AB Aim: Numerous studies have demonstrated that exercise acutely prevents the reduction in flow-mediated dilation induced by mental stress in subjects with metabolic syndrome (MetS). However, it is unknown whether a similar effect occurs in endothelial progenitors cells (EPCs). This study investigated whether exercise protects from the deleterious effect of mental stress on cultured EPCs in healthy subjects and those with MetS.
   Main methods: Ten healthy subjects (aged 31 +/- 2) and ten subjects with MetS (aged 36 +/- 2) were enrolled. Subjects underwent a mental stress test, followed immediately by either 40 mm of leg cycling or rest across two randomized sessions: mental stress + non-exercise control (MS) and mental stress + exercise (MS + EXE). The Stroop Color-Word Test was used to elicit mental stress. Blood samples were drawn at baseline and following sessions to isolate mononuclear cells. These cells were cultured in fibronectin-coated plates for seven days, and EPCs were identified by immunofluorescence (acLDL(+)/UEA-I Lectin(+)).
   Key findings: All subjects presented similar increases in mean blood pressure and heart rate during the mental stress test (P < 0.01) in both the MS and MS + EXE sessions. Number of EPCs was not different between groups at baseline in both sessions (P > 0.05). The EPC response to MS and MS + EXE was increased in healthy subjects, whereas it was decreased in subjects with MetS (P < 0.04). In healthy subjects, the EPC response to MS + EXE was greater than the response to MS alone (P = 0.03).
   Significance: An exercise session increased EPCs in healthy subjects but did not prevent the EPC reduction induced by mental stress among subjects with MetS. (C) 2015 Elsevier Inc. All rights reserved.
C1 [Rocha, Natalia G.; Sales, Allan R. K.; Miranda, Renan L.; Silva, Mayra S.; Silva, Jemima F. R.; Santos, Aline A.; Nobrega, Antonio C. L.] Univ Fed Fluminense, Dept Physiol & Pharmacol, Lab Exercise Sci, Rua Prof Hernani Pires de Melo 106,Sala 101, BR-24210130 Niteroi, RJ, Brazil.
   [Silva, Bruno M.] Univ Fed Sao Paulo, Sect Exercise Physiol, Dept Physiol, Sao Paulo, Brazil.
C3 Universidade Federal Fluminense; Universidade Federal de Sao Paulo
   (UNIFESP)
RP Nóobrega, ACL (corresponding author), Univ Fed Fluminense, Dept Physiol & Pharmacol, Lab Exercise Sci, Rua Prof Hernani Pires de Melo 106,Sala 101, BR-24210130 Niteroi, RJ, Brazil.
EM anobrega@id.uff.br
RI da Nobrega, Antonio/O-5107-2019; Sales, Allan/ABA-8691-2021; Rocha,
   Natalia Galito/AAN-7903-2020; Silva, Bruno/F-7781-2010
OI Miranda, Renan/0000-0002-3305-3913; Rocha, Natalia
   Galito/0000-0002-1990-9834; Silva, Bruno/0000-0003-0473-3706
FU National Council of Scientific and Technological Development (CNPq)
   [307251/2009-8]; State of Rio de Janeiro Agency (FAPERJ)
   [E-26/102.378/2009]; Coordination for the Improvement of Higher
   Education Personnel (CAPES) [2690/09-8]
FX This work was partially supported by research grants and scholarships
   provided by the National Council of Scientific and Technological
   Development (CNPq, 307251/2009-8), State of Rio de Janeiro Agency for
   Research Support (FAPERJ, E-26/102.378/2009); and Coordination for the
   Improvement of Higher Education Personnel (CAPES, 2690/09-8).
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NR 44
TC 10
Z9 10
U1 0
U2 5
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0024-3205
EI 1879-0631
J9 LIFE SCI
JI Life Sci.
PD FEB 15
PY 2015
VL 123
BP 93
EP 99
DI 10.1016/j.lfs.2014.12.026
PG 7
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA CC9RY
UT WOS:000350710000012
PM 25596018
OA hybrid
DA 2025-06-11
ER

PT J
AU Deer, LK
   Su, C
   Thwaites, NA
   Davis, EP
   Doom, JR
AF Deer, LillyBelle K.
   Su, Chen
   Thwaites, Natalie A.
   Davis, Elysia Poggi
   Doom, Jenalee R.
TI A framework for testing pathways from prenatal stress-responsive
   hormones to cardiovascular disease risk
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Review
DE cardiovascular disease (CVD); cortisol; placental CRH; health behaviors;
   cardiometabolic risk
ID CORTICOTROPIN-RELEASING HORMONE; 11-BETA-HYDROXYSTEROID DEHYDROGENASE
   TYPE-2; CORONARY-HEART-DISEASE; ANTENATAL CORTICOSTEROID-THERAPY;
   SHORT-SLEEP DURATION; LOW-BIRTH-WEIGHT; MATERNAL CORTISOL; PRETERM
   BIRTH; INDUCED SENSITIZATION; PHYSICAL-ACTIVITY
AB Cardiovascular disease (CVD) is a leading cause of death globally, with the prevalence projected to keep rising. Risk factors for adult CVD emerge at least as early as the prenatal period. Alterations in stress-responsive hormones in the prenatal period are hypothesized to contribute to CVD in adulthood, but little is known about relations between prenatal stress-responsive hormones and early precursors of CVD, such as cardiometabolic risk and health behaviors. The current review presents a theoretical model of the relation between prenatal stress-responsive hormones and adult CVD through cardiometabolic risk markers (e.g., rapid catch-up growth, high BMI/adiposity, high blood pressure, and altered blood glucose, lipids, and metabolic hormones) and health behaviors (e.g., substance use, poor sleep, poor diet and eating behaviors, and low physical activity levels). Emerging evidence in human and non-human animal literatures suggest that altered stress-responsive hormones during gestation predict higher cardiometabolic risk and poorer health behaviors in offspring. This review additionally highlights limitations of the current literature (e.g., lack of racial/ethnic diversity, lack of examination of sex differences), and discusses future directions for this promising area of research.
C1 [Deer, LillyBelle K.; Su, Chen; Thwaites, Natalie A.; Davis, Elysia Poggi; Doom, Jenalee R.] Univ Denver, Dept Psychol, Denver, CO 80208 USA.
   [Davis, Elysia Poggi] Univ Calif Irvine, Dept Psychiat & Human Behav, Irvine, CA USA.
C3 University of Denver; University of California System; University of
   California Irvine
RP Deer, LK (corresponding author), Univ Denver, Dept Psychol, Denver, CO 80208 USA.
EM lillybelle.deer@du.edu
RI Deer, LillyBelle/W-9369-2019; Davis, Elysia/B-7621-2013
FU National Heart, Lung, and Blood Institute [F32HL165844, K01HL143159,
   R01HL155744]; National Institute of Mental Health [R01MH109662]
FX Funding This manuscript was prepared with support from the National
   Heart, Lung, and Blood Institute grants F32HL165844 to LKD, K01HL143159
   to JRD, and R01HL155744 to EPD and JRD as well as from the National
   Institute of Mental Health grant R01MH109662 to EPD.
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NR 214
TC 8
Z9 8
U1 0
U2 4
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD MAY 8
PY 2023
VL 14
AR 1111474
DI 10.3389/fendo.2023.1111474
PG 15
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA G6MO4
UT WOS:000990278700001
PM 37223037
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Blazer, DG
   Hybels, CF
   Fillenbaum, GG
AF Blazer, DG
   Hybels, CF
   Fillenbaum, GG
TI Metabolic syndrome predicts mobility decline in a community-based sample
   of older adults
SO JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
LA English
DT Article
DE functional status; mobility; metabolic syndrome; older adults
ID MAINTAINING MOBILITY; DISABILITY; RISK; HEALTH
AB OBJECTIVES: To determine whether metabolic syndrome is an independent predictor of decline in mobility in an elderly community sample.
   DESIGN: Biracial community-based prospective cohort study.
   SETTING: Urban and rural areas of central North Carolina.
   PARTICIPANTS: One thousand two hundred twenty-nine older African Americans and whites, mean age 77.0, who were participants in the Duke Established Populations for Epidemiologic Studies of the Elderly.
   MEASUREMENTS: Sociodemographic data and data on mobility (a subset of items from the Rosow-Breslau scale), depression (Center for Epidemiological Studies Depression Scale), self-report of medical conditions, body mass index, cognitive function (Short Portable Mental Status Questionnaire), blood pressure, height, and waist circumference. High-density lipoprotein cholesterol, triglycerides, and blood glucose were available from blood samples. Metabolic syndrome was calculated for subjects with complete data.
   RESULTS: Twenty-nine percent of the sample met criteria for metabolic syndrome. In bivariate analyses, age, sex, race, education, cognitive impairment, depression, impairment in mobility, history of stroke and heart disease, and metabolic syndrome at baseline were associated with a decline in mobility 4 years later. Regression analysis controlling for the above variables demonstrated that metabolic syndrome persisted as an independent and highly significant predictor of decline in mobility.
   CONCLUSION: These findings suggest that metabolic syndrome may be a distinct risk factor for mobility decline in community-dwelling older people.
C1 Duke Univ, Med Ctr, Dept Psychiat & Behav Sci, Durham, NC 27710 USA.
   Duke Univ, Med Ctr, Ctr Study Aging & Human Dev, Durham, NC 27710 USA.
   Vet Adm Med Ctr, Geriatr Res & Clin Ctr, Durham, NC USA.
C3 Duke University; Duke University; US Department of Veterans Affairs;
   Veterans Health Administration (VHA)
RP Duke Univ, Med Ctr, Dept Psychiat & Behav Sci, Box 3003, Durham, NC 27710 USA.
EM blaze001@mc.duke.edu
FU NIA NIH HHS [5P60 AG11268, 5R01-AG20613, N01-AG12102] Funding Source:
   Medline; NIMH NIH HHS [1 K01 MH066380-01A1] Funding Source: Medline
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NR 22
TC 47
Z9 51
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0002-8614
EI 1532-5415
J9 J AM GERIATR SOC
JI J. Am. Geriatr. Soc.
PD MAR
PY 2006
VL 54
IS 3
BP 502
EP 506
DI 10.1111/j.1532-5415.2005.00607.x
PG 5
WC Geriatrics & Gerontology; Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA 017ZB
UT WOS:000235731000017
PM 16551320
DA 2025-06-11
ER

PT J
AU Temel, B
   Orenay, OM
   Karaosmanoglu, N
AF Temel, Berkay
   Orenay, Ozge Mine
   Karaosmanoglu, Nermin
TI Eating Disorder Risk Factors and the Impact of Obesity in Patients With
   Psoriasis
SO CUTIS
LA English
DT Article
ID QUALITY-OF-LIFE; METABOLIC SYNDROME; DISEASE
AB Current evidence indicates that obesity may initiate psoriasis or worsen existing disease. Various factors contribute to the development of obesity, including eating disorders (EDs). The aim of this study was to screen for and identify factors associated with EDs in patients with psoriasis and their impact on the development of obesity in this population. Demographic information including body mass index (BMI), Eating Attitude Test (EAT-26), Dermatology Life Quality Index (DLQI), Attitude Scale for Healthy Nutrition (ASHN), and Depression Anxiety Stress Scale 21 (DASS-21) scores were statistically analyzed for 82 participants with psoriasis at a tertiary dermatology clinic. It is important to manage obesity and other comorbidities of psoriasis in addition to treating its cutaneous manifestations, which may require a biopsychosocial approach.
C1 [Temel, Berkay; Orenay, Ozge Mine; Karaosmanoglu, Nermin] Ankara Numune Training & Res Hosp, Dept Dermatol, Minist Hlth, Ankara, Turkiye.
C3 Ankara Numune Training & Research Hospital; Ministry of Health - Turkey
RP Temel, B (corresponding author), Ankara Numune Training & Res Hosp, Dept Dermatol, Ulucanlar St 89, Ankara, Turkiye.
EM berkaytemel42@gmail.com
RI Orenay, ozge/GRO-0612-2022; Temel, Berkay/LYO-7723-2024; karaosmanoğlu,
   nermin/ABA-8258-2020
OI Temel, Berkay/0000-0001-5528-9006
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NR 30
TC 0
Z9 0
U1 0
U2 0
PU QUADRANT HEALTHCOM INC
PI PARSIPPANY
PA 7 CENTURY DRIVE, STE 302, PARSIPPANY, NJ 07054-4603 USA
SN 0011-4162
EI 2326-6929
J9 CUTIS
JI Cutis
PD NOV
PY 2024
VL 114
IS 5
DI 10.12788/cutis.1130
PG 10
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA N0N0I
UT WOS:001361388200006
PM 39787301
DA 2025-06-11
ER

PT J
AU Özdemir, O
   Kurdoglu, Z
   Yildiz, S
   Özdemir, PG
   Yilmaz, E
AF Ozdemir, Osman
   Kurdoglu, Zehra
   Yildiz, Saliha
   Ozdemir, Pinar Guzel
   Yilmaz, Ekrem
TI The relationship between atypical depression and insulin resistance in
   patients with polycystic ovary syndrome and major depression
SO PSYCHIATRY RESEARCH
LA English
DT Article
DE Polycystic ovary syndrome; Atypical depression; Insulin resistance;
   Suicidality
ID METABOLIC SYNDROME; ALZHEIMERS-DISEASE; CLINICAL-COURSE; WOMEN; ANXIETY;
   SYMPTOMS; DISORDERS; FEATURES; RISK; TESTOSTERONE
AB In this study, we aimed to examine the relationship between atypical depression and insulin resistance (IR) in patients with polycystic ovary syndrome (PCOS) and major depression. A total of 176 subjects (69 patients with PCOS, 58 patients with depression, and 49 healthy controls) were included in the study. The Beck Depression Inventory (BDI), the Beck Anxiety Inventory (BAT), the Beck Hopelessness Scale (BHS), and the Scale for Suicide Ideation (SSI) were administered. Data concerning their height, weight, fasting a.m. serum levels of insulin, glucose level, and total testosterone level were collected from all participants. The body mass index (BMI) and the Homeostasis Model Assessment Insulin Resistance index (HOMA-IR) were both calculated. 34 (49.3%) of the PCOS patients met the criteria for depression. 26 (76.5%) of them had atypical depression, 8 (23.5%) had non-atypical depression. 27 (46.6%) of the 58 depressed patients had atypical depression. Insulin resistance was higher in the PCOS patients than in the control subjects and the depression patients. There was no association between atypical depression and IR in patients with PCOS and depression. We concluded that there is no relationship between IR and atypical depression.
C1 [Ozdemir, Osman; Ozdemir, Pinar Guzel; Yilmaz, Ekrem] Yuzuncu Yil Univ, Fac Med, Dept Psychiat, Van, Turkey.
   [Kurdoglu, Zehra] Ankara Numune Training & Res Hosp, Dept Obstet & Gynecol, Ankara, Turkey.
   [Yildiz, Saliha] Yuzuncu Yil Univ, Fac Med, Dept Endocrinol, Van, Turkey.
C3 Yuzuncu Yil University; Ankara Numune Training & Research Hospital;
   Yuzuncu Yil University
RP Özdemir, O; Özdemir, PG (corresponding author), Yuzuncu Yil Univ, Fac Med, Dept Psychiat, Van, Turkey.
EM drosmanozdemir@yahoo.com; zehrakurdoglu@hotmail.com;
   salihacekici_34@hotmail.com; pguzelozdemir@yahoo.com;
   ekrem.yilmaz.84@hotmail.com
RI Kurdoglu, Zehra/A-2453-2019
OI Kurdoglu, Zehra/0000-0001-5191-1072
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NR 47
TC 11
Z9 13
U1 3
U2 17
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0165-1781
EI 1872-7123
J9 PSYCHIAT RES
JI Psychiatry Res.
PD DEC
PY 2017
VL 258
BP 171
EP 176
DI 10.1016/j.psychres.2016.11.043
PG 6
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA FN7FQ
UT WOS:000416184500027
PM 28168992
DA 2025-06-11
ER

PT J
AU Lutfi, MF
AF Lutfi, Mohamed Faisal
TI Anxiety Level and Cardiac Autonomic Modulations in Coronary Artery
   Disease and Cardiac Syndrome X Patients
SO PLOS ONE
LA English
DT Article
ID HEART-RATE-VARIABILITY; RISK-FACTORS; CHEST-PAIN; ANGINA; DEPRESSION;
   DISORDERS; ISCHEMIA; IMPACT; WOMEN
AB Background
   Anxiety and cardiac autonomic modulations (CAM) were thoroughly investigated in coronary artery disease (CAD) and cardiac syndrome X (CSX) patients worldwide, but not among Sudanese with similar pathology.
   Aims
   To compare levels of anxiety and CAM between Sudanese patients with CSX and CAD.
   Materials and Methods
   Anxiety was evaluated in 51 CAD and 26 CSX patients using Taylor Manifest anxiety score (TMAS) questionnaire while heart rate variability derived indices were used to assess CAM, namely natural logarithm of low frequency (LnLF), high frequency (LnHF) and LF/HF ratio (LnLF/HF).
   Results
   Low anxiety levels were achieved by 6 (23.1%) and 9 (17.6%) patients with CSX and CAD respectively. High anxiety level was achieved by only one (3.8%) patient, who was suffering from CSX. TMAS was significantly higher in CSX (31.27 (21.97)) compared to CAD (21.86 (12.97), P = 0.021). However, abnormally increased anxiety was not associated with higher risk of CSX. LnLF, LnHF and LnLF/HF were comparable in CAD and CSX patients.
   Conclusion
   CSX and CAD patients showed comparable CAM. Although anxiety levels were higher in CSX compared to CAD, TMAS >= 35 failed to show significant association with CSX.
C1 [Lutfi, Mohamed Faisal] Al Neelain Univ, Fac Med & Hlth Sci, Dept Physiol, Khartoum, Sudan.
RP Lutfi, MF (corresponding author), Al Neelain Univ, Fac Med & Hlth Sci, Dept Physiol, Khartoum, Sudan.
EM mohamedfaisallutfi@gmail.com
RI Lutfi, Mohamed/LTF-3068-2024; Stefanadis, Christodoulos/ABH-2232-2020
OI Stefanadis, Christodoulos/0000-0001-5974-6454
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NR 45
TC 7
Z9 7
U1 0
U2 8
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JAN 9
PY 2017
VL 12
IS 1
AR e0170086
DI 10.1371/journal.pone.0170086
PG 9
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA EH5WO
UT WOS:000391843900085
PM 28068419
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Li, P
   Wang, B
   Sun, F
   Li, YS
   Li, Q
   Lang, HM
   Zhao, ZG
   Gao, P
   Zhao, Y
   Shang, QH
   Yan, ZC
   Liu, DY
   Zhu, ZM
AF Li, Peng
   Wang, Bin
   Sun, Fang
   Li, Yingsha
   Li, Qiang
   Lang, Hongmei
   Zhao, Zhigang
   Gao, Peng
   Zhao, Yu
   Shang, Qianhui
   Yan, Zhencheng
   Liu, Daoyan
   Zhu, Zhiming
TI Mitochondrial respiratory dysfunctions of blood mononuclear cells link
   with cardiac disturbance in patients with early-stage heart failure
SO SCIENTIFIC REPORTS
LA English
DT Article
ID OXIDATIVE STRESS; CALCIUM INFLUX; INFLAMMATION; HYPERTENSION; RISK;
   OBESITY; PROGRESSION; MONOCYTES
AB Patients with cardiometabolic risk factors and asymptomatic cardiac hypertrophy are hallmarks of early-stage heart failure (HF). We hypothesized that mitochondrial respiratory dysfunctions of peripheral blood mononuclear cells (PBMCs) may be associated with inflammation and oxidative stress in early-stage HF patients complicated with cardiometabolic risk factors. Totally 49 subjects were enrolled with 25 early-stage HF patients (stages A and B) having cardiac hypertrophy and dysfunction and 24 healthy controls. It showed that excessive inflammation and reduced antioxidant capacity were closely associated with cardiac abnormalities in early-stage HF patients. Furthermore, the values of mitochondrial respiratory functional parameters R, CIOXPHOS, CIIOXPHOS, CI+IIOXPHOS, CI+IIETS and CIIETS were significantly lowered in early-stage HF patients. Interestingly, these respiratory parameters were correlated with inflammation and antioxidant capacity in participants. Finally, cardiometabolic risk factors such as salt intake and blood pressure were related to the mitochondrial respiratory dysfunctions, which were further validated by in vitro experiments. Our study indicated that cardiometabolic risk factor-mediated mitochondrial respiratory dysfunctions of PBMCs link with the cellular inflammation / oxidative stress and cardiac disturbance in early-stage HF.
C1 [Li, Peng; Wang, Bin; Sun, Fang; Li, Yingsha; Li, Qiang; Lang, Hongmei; Zhao, Zhigang; Gao, Peng; Yan, Zhencheng; Liu, Daoyan; Zhu, Zhiming] Third Mil Med Univ, Chongqing Inst Hypertens, Dept Hypertens & Endocrinol, Ctr Hypertens & Metab Dis,Daping Hosp, Chongqing 400042, Peoples R China.
   [Li, Peng; Zhao, Yu; Shang, Qianhui] Zunyi Med Coll, Inst Clin Med, Affiliated Hosp, Dept Cardiol, Zunyi 563003, Guizhou, Peoples R China.
C3 Army Medical University; Zunyi Medical University
RP Liu, DY (corresponding author), Third Mil Med Univ, Chongqing Inst Hypertens, Dept Hypertens & Endocrinol, Ctr Hypertens & Metab Dis,Daping Hosp, Chongqing 400042, Peoples R China.
EM daoyanliu@yahoo.com; zhuzm@yahoo.com
RI Li, Qiang/MVY-4701-2025; Zhu, Zhiming/AAH-6111-2021
OI Wang, Bin/0000-0002-8403-080X
FU National Basic Research Program of China [2013CB531205, 2013CB531104,
   2012CB517805, 2011CB503902]; National Natural Science Foundation of
   China [81370353, 81130006, 91339112, 91339000]; PCSIRT
FX We kindly appreciated Tingbing Cao, Lijuan Wang, Li Li and ShiqiangXiong
   (Chongqing Institute of Hypertension, Chongqing, China) for technical
   instructions in our experiments. This study was funded by the National
   Basic Research Program of China (2013CB531205, 2013CB531104,
   2012CB517805 and 2011CB503902), the National Natural Science Foundation
   of China (81370353, 81130006, 91339112 and 91339000) and supported by
   PCSIRT.
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NR 32
TC 57
Z9 59
U1 0
U2 13
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD MAY 28
PY 2015
VL 5
AR 10229
DI 10.1038/srep10229
PG 11
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA CJ5RB
UT WOS:000355545000001
PM 26018291
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Mellor, DD
   Naumovski, N
AF Mellor, Duane D.
   Naumovski, Nenad
TI Effect of cocoa in diabetes: the potential of the pancreas and liver as
   key target organs, more than an antioxidant effect?
SO INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
LA English
DT Review
DE Antioxidants; chocolate; cocoa; health foods
ID CARDIOMETABOLIC RISK-FACTORS; RANDOMIZED CONTROLLED-TRIAL; RICH DARK
   CHOCOLATE; BETA-CELL FUNCTION; INSULIN-RESISTANCE; OXIDATIVE STRESS;
   BLOOD-PRESSURE; METABOLIC SYNDROME; OBESE SUBJECTS; FATTY RATS
AB Increasingly, type 2 diabetes mellitus is being linked to metabolic abnormalities within the liver and pancreas, associated with fat deposition and oxidative stress. Cocoa and chocolate have been seen to improve oxidative stress and enhance insulin sensitivity. Recent invitro and animal model studies have begun to investigate the potential of cocoa and cocoa extracts in modulating fatty liver and pancreatic function. Evidence from these studies has highlighted a number of mechanisms, which facilitate insulin secretion and enhanced survival in pancreatic beta cells. Whilst in liver, improved effect of insulin was observed with some improvements in fatty infiltration. However, what was seen as a common effect was an increase in endogenous antioxidant capability. The potential of cocoa products in the management of fatty liver and supporting pancreatic function in humans is likely to be limited by their macronutrient and energy profile or palatability, unless taken as cocoa extract supplements.
C1 [Mellor, Duane D.; Naumovski, Nenad] Univ Canberra, Fac Hlth, Sch Publ Hlth & Nutr, Discipline Nutr & Dietet, Canberra, ACT 2617, Australia.
   [Mellor, Duane D.] Univ Nottingham, Sch Biosci, Div Nutr Sci, Sutton Bonington Campus,Coll Rd, Loughborough LE12 5RD, Leics, England.
C3 University of Canberra; University of Nottingham
RP Mellor, DD (corresponding author), Univ Canberra, Fac Hlth, Sch Publ Hlth & Nutr, Discipline Nutr & Dietet, Canberra, ACT 2617, Australia.
EM duane.mellor@canberra.edu.au
RI Mellor, Duane/Q-2184-2019; Naumovski, Nenad/O-5617-2015; Mellor,
   Duane/H-1262-2012
OI Naumovski, Nenad/0000-0002-2841-4497; Mellor, Duane/0000-0002-1369-3868
FU Barry Callebaut; Nestle
FX DDM has received funding in the past to undertake human clinical trials
   involving chocolate from Barry Callebaut and Nestle.
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NR 92
TC 8
Z9 8
U1 0
U2 32
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0950-5423
EI 1365-2621
J9 INT J FOOD SCI TECH
JI Int. J. Food Sci. Technol.
PD APR
PY 2016
VL 51
IS 4
BP 829
EP 841
DI 10.1111/ijfs.13075
PG 13
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA DH6TS
UT WOS:000372925300001
DA 2025-06-11
ER

PT J
AU Hilty, DM
   McCarron, RM
   Ton, H
AF Hilty, Donald M.
   McCarron, Robert M.
   Ton, Hendry
TI Management of mental illness in patients with diabetes
SO PRIMARY CARE
LA English
DT Article
ID CORTICOTROPIN-RELEASING-FACTOR; PRIMARY-CARE; METABOLIC SYNDROME;
   ANXIETY DISORDERS; RISK-FACTORS; PREVALENCE; DEPRESSION; MELLITUS;
   TRIAL; SCHIZOPHRENIA
AB Patients who have diabetes commonly have mood, anxiety, and psychotic disorders. These disorders may have multiple biologic underpinnings. Without treatment, care becomes complicated and outcomes are poor. Early diagnosis and biopsychosocial treatment that integrates medical and psychiatric interventions is highly desirable. Medications have a major role in treatment, although caution must be exercised because of potential side effects. Psychiatric consultation or management may be required for urgent or severe cases. An appreciation of culture, both ethnic and beyond, is a foundation for enhancing physician-patient relations and developing realistic expectations for treatment.
C1 [Hilty, Donald M.; McCarron, Robert M.; Ton, Hendry] Univ Calif Davis, Sacramento, CA 95817 USA.
C3 University of California System; University of California Davis
RP Hilty, DM (corresponding author), Univ Calif Davis, Sacramento, CA 95817 USA.
EM dmhilty@ucdavis.edu
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NR 46
TC 2
Z9 2
U1 0
U2 5
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0095-4543
EI 1558-299X
J9 PRIMARY CARE
JI Primary Care
PD DEC
PY 2007
VL 34
IS 4
BP 713
EP +
DI 10.1016/j.pop.2007.08.001
PG 19
WC Primary Health Care; Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA 248SV
UT WOS:000252176600003
PM 18061815
DA 2025-06-11
ER

PT J
AU Martino, G
   Catalano, A
   Bellone, F
   Russo, GT
   Vicario, CM
   Lasco, A
   Quattropani, MC
   Morabito, N
AF Martino, Gabriella
   Catalano, Antonino
   Bellone, Federica
   Russo, Giuseppina Tiziana
   Vicario, Carmelo Mario
   Lasco, Antonino
   Quattropani, Maria Catena
   Morabito, Nunziata
TI As Time Goes by: Anxiety Negatively Affects the Perceived Quality of
   Life in Patients With Type 2 Diabetes of Long Duration
SO FRONTIERS IN PSYCHOLOGY
LA English
DT Article
DE chronic diseases; anxiety; depression; quality of life; physical
   component summary; mental component summary; type 2 diabetes
ID METABOLIC SYNDROME; SELF-MANAGEMENT; HEALTH SURVEY; ADULTS; DEPRESSION;
   RISK; CARE; INFLAMMATION; PREVALENCE; ACCEPTANCE
AB Introduction: Age-related medical conditions are increasing worldwide. Type 2 Diabetes mellitus (T2DM) represents a chronic disease, which affects a large amount of general population, accounting for over 90% of diabetes mellitus (DM) cases.
   Purpose: As psychopathological symptoms frequently occur in medical conditions, our study aimed at exploring whether psychological factors and metabolic control may affect health related quality of life (HRQoL).
   Methods: Forty five patients with T2DM were consecutively recruited and assessed with a psychodiagnostic battery: Hamilton Anxiety Rating Scale (HAM-A), Beck Depression Inventory II edition (BDI-II) and the 36-Item Short Form Health Survey (SF-36), including indexes Physical and Mental Component Summary (PCS, MCS). Moreover, time since DM diagnosis and glycated hemoglobin (HbA1c) values were detected.
   Results: Participants (mean age 65.3 +/- 5.9 years) had a mean time since diagnosis of 11.6 +/- 6.7 years, and showed a good metabolic control as highlighted by mean HbA1c values 7.1 +/- 0.9%. Median HAM-A score [25(20.7-30.6)], represented high prevalence of anxious symptoms. A moderate expression of depressive symptoms was observed [BDI-II score: 13(8.3-21.4)]. A multiple regression analysis, after correcting for age, BMI, HbA1c value and BDI-II score, showed the perceived quality of life relative to PCS was significantly related to both disease duration (beta = -0.55, p = 0.03, SE = 0.25) and HAM-A scores (beta = -0.52, p = 0.04, SE = 0.24). Moreover, both HAM-A (beta = -0.67, p = 0.01, SE = 0.26) and BDI-II (beta = -0.48, p = 0.02, SE = 0.20) scores were independently predictive of MCS. Metabolic control, instead, was not a significant predictor.
   Conclusion: Our study suggests a predictive role of both anxiety levels and time since diagnosis in perceived HRQoL in T2DM patients. PCS was associated with anxiety and time since diagnosis and MCS was associated with anxiety and depressive symptoms but not with diabetes duration or metabolic control. These data could be useful to plan T2DM training programs focused on psychological health concerns, possibly leading to a healthy self-management and a better perceived HRQoL, even assisting patients in reducing the negative effect due to the chronicization of T2DM.
C1 [Martino, Gabriella; Catalano, Antonino; Bellone, Federica; Russo, Giuseppina Tiziana; Lasco, Antonino; Quattropani, Maria Catena; Morabito, Nunziata] Univ Messina, Dept Clin & Expt Med, Messina, Italy.
   [Vicario, Carmelo Mario] Univ Messina, Dept Cognit Sci Psychol Educ & Cultural Studies, Messina, Italy.
C3 University of Messina; University of Messina
RP Martino, G (corresponding author), Univ Messina, Dept Clin & Expt Med, Messina, Italy.
EM martinog@unime.it
RI Quattropani, Maria/G-3504-2015; Russo, Giuseppina/AIC-4440-2022;
   VICARIO, CARMELO/AAR-2521-2021; MARTINO, Gabriella/U-9158-2018; Bellone,
   Federica/AEC-3095-2022; Catalano, Antonino/H-7109-2016
OI MARTINO, Gabriella/0000-0001-9488-2021; Bellone,
   Federica/0000-0002-0467-4921; Catalano, Antonino/0000-0003-3890-2299;
   Quattropani, Maria C./0000-0003-0711-6412; RUSSO, GIUSEPPINA
   Tiziana/0000-0002-4565-3131
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NR 62
TC 59
Z9 64
U1 0
U2 8
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-1078
J9 FRONT PSYCHOL
JI Front. Psychol.
PD JUL 31
PY 2019
VL 10
AR 1779
DI 10.3389/fpsyg.2019.01779
PG 8
WC Psychology, Multidisciplinary
WE Social Science Citation Index (SSCI)
SC Psychology
GA IM4XI
UT WOS:000477998200001
PM 31428028
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Goldfield, GS
   Murray, M
   Maras, D
   Wilson, AL
   Phillips, P
   Kenny, GP
   Hadjiyannakis, S
   Alberga, A
   Cameron, JD
   Tulluch, H
   Sigal, RJ
AF Goldfield, Gary S.
   Murray, Marisa
   Maras, Danijela
   Wilson, Angela L.
   Phillips, Penny
   Kenny, Glen P.
   Hadjiyannakis, Stasia
   Alberga, Angela
   Cameron, Jameason D.
   Tulluch, Heather
   Sigal, Ronald J.
TI Screen time is associated with depressive symptomatology among obese
   adolescents: a HEARTY study
SO EUROPEAN JOURNAL OF PEDIATRICS
LA English
DT Article
DE Pediatric obesity; Overweight; Screen time; Media use; Depression;
   Mental health; Sedentary behavior
ID PHYSICAL-ACTIVITY; SEDENTARY BEHAVIOR; MEDIA USE; INTERNET USE;
   PSYCHOLOGICAL ADJUSTMENT; SOCIOECONOMIC-STATUS; METABOLIC RISK;
   UNITED-STATES; CHILDREN; HEALTH
AB Obese adolescents spend a disproportionate time in screen-based activities and are at higher risk for clinical depression compared to their normal-weight peers. While screen time is associated with obesity and cardiometabolic risk factors, little is known about the relationship between screen time and mental health. This cross-sectional study examines the association between duration and types of screen time and depressive symptomatology (subclinical symptoms) in a sample of 358 (261 female; 97 male) overweight and obese adolescents aged 14-18 years. Self-report measures assessed depressive symptoms and time spent in different types of screen behavior (TV, recreational computer use, and video games). After controlling for age, ethnicity, sex, parental education, body mass index (BMI), physical activity, caloric intake, carbohydrate intake, and intake of sugar-sweetened beverages, total screen time was significantly associated with more severe depressive symptomatology (beta = 0.21, p = 0.001). After adjustment, time spent playing video games (beta = 0.13, p = 0.05) and recreational computer time (beta = 0.18, p = 0.006) was associated with depressive symptoms, but TV viewing was not.
   Conclusions: Screen time may represent a risk factor or marker of depressive symptomatology in obese adolescents. Future intervention research should evaluate whether reducing screen exposure reduces depressive symptoms in obese youth, a population at increased risk for psychological disorders.
C1 [Goldfield, Gary S.; Hadjiyannakis, Stasia; Cameron, Jameason D.] Childrens Hosp Eastern Ontario, Res Inst, Hlth Act Living & Obes HALO Res Grp, 401 Smyth Rd, Ottawa, ON K1H 8L1, Canada.
   [Goldfield, Gary S.] Univ Ottawa, Dept Pediat, Ottawa, ON K1N 6N5, Canada.
   [Goldfield, Gary S.; Kenny, Glen P.; Alberga, Angela] Univ Ottawa, Sch Human Kinet, Ottawa, ON, Canada.
   [Goldfield, Gary S.; Murray, Marisa; Wilson, Angela L.] Univ Ottawa, Sch Psychol, Ottawa, ON K1N 6N5, Canada.
   [Goldfield, Gary S.; Maras, Danijela] Carleton Univ, Dept Psychol, Ottawa, ON K1S 5B6, Canada.
   [Phillips, Penny] Ottawa Hosp Res Inst, Ottawa, ON, Canada.
   [Hadjiyannakis, Stasia] Childrens Hosp Eastern Ontario, CHAL, Ottawa, ON K1H 8L1, Canada.
   [Tulluch, Heather] Univ Ottawa, Inst Heart, Prevent & Rehabil Ctr, Ottawa, ON, Canada.
   [Sigal, Ronald J.] Univ Calgary, Dept Med Cardiac Sci & Community Hlth Sci, Fac Med, Calgary, AB, Canada.
   [Sigal, Ronald J.] Univ Calgary, Dept Med Cardiac Sci & Community Hlth Sci, Fac Kinesiol, Calgary, AB, Canada.
C3 University of Ottawa; Children's Hospital of Eastern Ontario; University
   of Ottawa; University of Ottawa; University of Ottawa; Carleton
   University; University of Ottawa; Ottawa Hospital Research Institute;
   University of Ottawa; Children's Hospital of Eastern Ontario; University
   of Ottawa; University of Ottawa Heart Institute; University of Calgary;
   University of Calgary
RP Goldfield, GS (corresponding author), Childrens Hosp Eastern Ontario, Res Inst, Hlth Act Living & Obes HALO Res Grp, 401 Smyth Rd, Ottawa, ON K1H 8L1, Canada.; Goldfield, GS (corresponding author), Univ Ottawa, Dept Pediat, Ottawa, ON K1N 6N5, Canada.; Goldfield, GS (corresponding author), Univ Ottawa, Sch Human Kinet, Ottawa, ON, Canada.; Goldfield, GS (corresponding author), Univ Ottawa, Sch Psychol, Ottawa, ON K1N 6N5, Canada.
EM ggoldfield@cheo.on.ca; mmurr087@uottawa.ca; danijelamaras@gmail.com;
   awils046@uottawa.ca; pphillips@orhri.ca; gkenny@uottawa.ca;
   shadjiyannakis@uottawa.ca; aalberga@ucalgary.ca; jcameron@cheo.on.ca;
   hetulloch@ottawaheart.ca; rsigal@ucalgary.ca
RI Sigal, Ron/AAK-7627-2020
OI Maras, Danijela/0000-0003-3963-1267; Goldfield, Gary/0000-0001-6216-7824
FU Canadian Institutes of Health Research [MCT-71979]
FX Data were collected as part of the Healthy Eating, Aerobic, and
   Resistance Training for Youth (HEARTY) trial (Clinicaltrials.gov
   Registration: NCT00195858), which was supported by a grant from the
   Canadian Institutes of Health Research (grant number MCT-71979).
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NR 73
TC 36
Z9 41
U1 3
U2 44
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0340-6199
EI 1432-1076
J9 EUR J PEDIATR
JI Eur. J. Pediatr.
PD JUL
PY 2016
VL 175
IS 7
BP 909
EP 919
DI 10.1007/s00431-016-2720-z
PG 11
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Pediatrics
GA DP5XH
UT WOS:000378571000004
PM 27075014
DA 2025-06-11
ER

PT J
AU Isasi, CR
   Rastogi, D
   Molina, K
AF Isasi, Carmen R.
   Rastogi, Deepa
   Molina, Kristine
TI Health Issues in Hispanic/Latino Youth
SO JOURNAL OF LATINA-O PSYCHOLOGY
LA English
DT Article
DE Hispanic; children; asthma; mental health; obesity
ID CARDIOMETABOLIC RISK-FACTORS; FATTY LIVER-DISEASE; PUERTO-RICAN YOUTH;
   BODY-MASS INDEX; CHILDHOOD OBESITY; MENTAL-HEALTH;
   PSYCHIATRIC-DISORDERS; CARDIOVASCULAR RISK; ASTHMA CONTROL;
   UNITED-STATES
AB This review focuses on obesity, asthma, and mental health functioning as salient health issues affecting Hispanic youth. The burden of these conditions and consequences for adult health are also discussed. Hispanic youth are affected by obesity at an early age; the prevalence of obesity among Hispanic children 6-11 years old is twice as high as the prevalence for non-Hispanic White children of the same age, but among 2-5 years old is 4 times higher. Asthma disproportionally affects certain Hispanic groups, notably children of Puerto Rican ancestry, and the comorbidity of asthma and obesity is an emerging health issue. Another area of concern is the scant data on mental health functioning among Hispanic youth. Research on Hispanic youth mental health have reported high rates of depressive symptomatology and high rates of alcohol use among Hispanic adolescents but despite these findings, they have inadequate access to mental health services. This review highlights the need for better data to gain a better understanding of the health status of Hispanic youth and help develop preventive programs that addresses the need of this population. Improving access to health services, in particular mental health services, is also a crucial aspect.
C1 [Isasi, Carmen R.] Albert Einstein Coll Med, Dept Epidemiol & Populat Hlth, 1300 Morris Pk Ave,Belfer Bldg 1308D, Bronx, NY 10461 USA.
   [Rastogi, Deepa] Albert Einstein Coll Med, Dept Pediat, Bronx, NY 10461 USA.
   [Molina, Kristine] Univ Illinois, Dept Psychol, Chicago, IL 60680 USA.
C3 Montefiore Medical Center; Albert Einstein College of Medicine; Yeshiva
   University; Montefiore Medical Center; Albert Einstein College of
   Medicine; Yeshiva University; University of Illinois System; University
   of Illinois Chicago; University of Illinois Chicago Hospital
RP Isasi, CR (corresponding author), Albert Einstein Coll Med, Dept Epidemiol & Populat Hlth, 1300 Morris Pk Ave,Belfer Bldg 1308D, Bronx, NY 10461 USA.
EM carmen.isasi@einstein.yu.edu
OI Rastogi, Deepa/0000-0001-5714-9250
FU National Heart, Lung, and Blood Institute [R01HL102130, K23HL118733];
   Eunice Shriver Kennedy National Institute of Child Health and Human
   Development [K12HD055892]
FX Supported by Grants R01HL102130 (CRI) and K23HL118733 (DR) from the
   National Heart, Lung, and Blood Institute, and Grant K12HD055892 (KM)
   from the Eunice Shriver Kennedy National Institute of Child Health and
   Human Development. The content is solely the responsibility of the
   authors and does not necessarily represent the official views of the
   National Heart, Lung, and Blood Institute, the Eunice Shriver Kennedy
   National Institute of Child Health and Human Development, or the
   National Institutes of Health.
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NR 131
TC 59
Z9 88
U1 1
U2 17
PU EDUCATIONAL PUBLISHING FOUNDATION-AMERICAN PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST, NE, WASHINGTON, DC 20002-4242 USA
SN 2168-1678
EI 2163-0070
J9 J LAT O PSYCHOL
JI J. Lat. Psychol.
PD MAY
PY 2016
VL 4
IS 2
SI SI
BP 67
EP 82
DI 10.1037/lat0000054
PG 16
WC Psychology, Clinical; Psychology, Developmental; Psychology,
   Multidisciplinary; Psychology, Social
WE Social Science Citation Index (SSCI)
SC Psychology
GA VB8OS
UT WOS:000419303400002
PM 27347457
OA Green Accepted, hybrid
DA 2025-06-11
ER

PT J
AU Tzellos, T
   Zouboulis, CC
AF Tzellos, Thrasyvoulos
   Zouboulis, Christos C.
TI Review of Comorbidities of Hidradenitis Suppurativa: Implications for
   Daily Clinical Practice
SO DERMATOLOGY AND THERAPY
LA English
DT Review
DE Clinical significance; Comorbidities; Depression; Hidradenitis
   suppurativa; Inflammatory bowel disease; Metabolic syndrome; Quality of
   life; Working disability
ID QUALITY-OF-LIFE; PSYCHOSOCIAL IMPACT; SEVERITY; PREVALENCE; HEALTH
AB Hidradenitis suppurativa (HS) is a chronic, recurrent skin inflammatory disease associated with a variety of comorbidities, like reduced quality of life, metabolic syndrome, sexual dysfunction, working disability, axial spondyloarthritis, inflammatory bowel disease, depression, and anxiety. Like psoriasis, HS patients have been found to have higher risk of cardiovascular death and suicide risk. Clinicians should be informed about these comorbidities so that appropriate screening is implemented. All this evidence suggests that for such a chronic, multi-comorbid disease, the use of validated outcomes to assess severity and effect of treatment, along with the use of clinically important patient reported outcomes, is essential. The potential of available treatments to negatively and positively affect these comorbidities should also be taken into account when designing treatment strategies. This review provides an outline of important HS comorbidities with emphasis on possible implications for daily clinical practice.
C1 [Tzellos, Thrasyvoulos] Nordland Hosp Trust, Dept Dermatol, Bodo, Norway.
   [Tzellos, Thrasyvoulos] Univ Tromso, Inst Clin Med, Tromso, Norway.
   [Zouboulis, Christos C.] Brandenburg Med Sch, Dessau Med Ctr, Dept Dermatol, Dessau, Germany.
   [Zouboulis, Christos C.] Brandenburg Med Sch, Dessau Med Ctr, Dept Venereol, Dessau, Germany.
   [Zouboulis, Christos C.] Brandenburg Med Sch, Dessau Med Ctr, Dept Allergol & Immunol, Dessau, Germany.
   [Zouboulis, Christos C.] European Hidradenitis Suppurat Fdn eV, Dessau, Germany.
C3 UiT The Arctic University of Tromso; Dessau Medical Center; Dessau
   Medical Center; Dessau Medical Center
RP Tzellos, T (corresponding author), Nordland Hosp Trust, Dept Dermatol, Bodo, Norway.
EM thrasyvoulos.tzellos@unn.no
RI Prof. Dr. Zouboulis, Christos/I-4493-2013
OI Tzellos, Thrasivoulos/0000-0003-2356-0847
CR Alavi A, 2018, Int J Womens Dermatol, V4, P74, DOI 10.1016/j.ijwd.2017.10.007
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NR 44
TC 46
Z9 46
U1 0
U2 2
PU ADIS INT LTD
PI NORTHCOTE
PA 5 THE WAREHOUSE WAY, NORTHCOTE 0627, AUCKLAND, NEW ZEALAND
SN 2193-8210
EI 2190-9172
J9 DERMATOLOGY THER
JI Dermatol. Ther.
PD FEB
PY 2020
VL 10
IS 1
BP 63
EP 71
DI 10.1007/s13555-020-00354-2
PG 9
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA KI7XG
UT WOS:000511564900006
PM 31955366
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Oh, EG
   Bang, SY
   Hyun, SS
   Kim, SH
   Chu, SH
   Jeon, JY
   Im, JA
   Lee, MK
   Lee, JE
AF Oh, Eui Geum
   Bang, So Youn
   Hyun, Sa Saeng
   Kim, Soo Hyun
   Chu, Sang Hui
   Jeon, Justin Y.
   Im, Jee-Aee
   Lee, Mi Kyung
   Lee, Jung Eun
TI Effects of a 6-month lifestyle modification intervention on the
   cardiometabolic risk factors and health-related qualities of life in
   women with metabolic syndrome
SO METABOLISM-CLINICAL AND EXPERIMENTAL
LA English
DT Article
ID RANDOMIZED CONTROLLED-TRIAL; WEIGHT-LOSS; CARDIOVASCULAR-DISEASE;
   POSTMENOPAUSAL WOMEN; LOW-CARBOHYDRATE; EXERCISE; DIET; INDIVIDUALS;
   PREVENTION; METFORMIN
AB Although therapeutic lifestyle modification (TLM) has been recommended as a cornerstone treatment of metabolic syndrome (MetS), little is known about the biobehavioral effects of a TLM program for patients in a community. The purpose of this study was to examine the effects of a 6-month TLM program on MetS risk factors and health-related qualities of life (HRQOL) among middle-aged and older women in a community in Korea. Fifty-two women (mean age, 62.7 +/- 9.0 years) with MetS were recruited from 3 community health centers and were randomly assigned to the intervention (n = 31) or control (n = 21) groups. The patients in the intervention group participated in supervised TLM sessions for 6 months. The TLM program included health monitoring, counseling, health education, exercise, and dieting. Metabolic risk factors and HRQOL were measured at baseline, during the study (month 3), at completion (month 6), and postcompletion (month 12) of the TLM program. Compared with the control group, the TLM group showed significantly greater reductions in body weight (P < .001) and waist circumference (P < .001); these effects were sustained for 6 months after intervention. With regard to HRQOL, the TLM group showed greater improvements in physical function (P = .017), general health (P < .001), vitality (P = .008), and mental health (P = .027). These improvements, however, were not sustained after the intervention. The results indicate that a nurse-led systematic TLM program may be an effective strategy for managing middle-aged and older women with MetS at a community level. (C) 2010 Elsevier Inc. All rights reserved.
C1 [Kim, Soo Hyun] Inha Univ, Dept Nursing, Inchon 402751, South Korea.
   [Oh, Eui Geum; Chu, Sang Hui; Lee, Jung Eun] Yonsei Univ, Coll Nursing, Nursing Policy & Res Inst, Seoul 120752, South Korea.
   [Bang, So Youn] Yongdong Univ, Yongdong 370751, South Korea.
   [Hyun, Sa Saeng] Galsan Community Hlth Ctr, Chung Won 363861, South Korea.
   [Jeon, Justin Y.; Lee, Mi Kyung] Yonsei Univ, Dept Sport & Leisure Studies, Seoul 120752, South Korea.
   [Im, Jee-Aee] INTOTO Inc, Sports & Med Res Ctr, Seoul 120180, South Korea.
C3 Inha University; Yonsei University; Yonsei University Health System;
   Yonsei University
RP Kim, SH (corresponding author), Inha Univ, Dept Nursing, Inchon 402751, South Korea.
EM soohyun@inha.ac.kr
RI Lee, Jee-Yon/GER-4141-2022
OI Lee, Mi Kyung/0000-0002-9690-4463; Jeon, Justin/0000-0001-7978-4271;
   Lee, Jung Eun/0000-0002-1195-3427; Oh, Eui Geum/0000-0002-6941-0708;
   CHU, Sang Hui/0000-0001-6877-5599
FU Korean Science and Engineering Foundation [R01-2006-000-11333-0]
FX This work was supported by the Korean Science and Engineering Foundation
   (R01-2006-000-11333-0).
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NR 37
TC 67
Z9 70
U1 1
U2 20
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0026-0495
EI 1532-8600
J9 METABOLISM
JI Metab.-Clin. Exp.
PD JUL
PY 2010
VL 59
IS 7
BP 1035
EP 1043
DI 10.1016/j.metabol.2009.10.027
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism
GA 611WH
UT WOS:000278854400015
PM 20045151
DA 2025-06-11
ER

PT J
AU Sabir, AA
   Bilbis, LS
   Saidu, Y
   Jimoh, A
   Iwuala, SO
   Isezuo, SA
   Kaoje, AU
   Abubakar, SA
AF Sabir, A. A.
   Bilbis, L. S.
   Saidu, Y.
   Jimoh, A.
   Iwuala, S. O.
   Isezuo, S. A.
   Kaoje, A. U.
   Abubakar, S. A.
TI Oxidative stress among subjects with metabolic syndrome in Sokoto,
   North-Western Nigeria
SO NIGERIAN JOURNAL OF CLINICAL PRACTICE
LA English
DT Article
DE Antioxidants; metabolic syndrome; oxidative stress
ID VITAMIN-E; ANTIOXIDANT CONCENTRATIONS; ENDOTHELIAL DYSFUNCTION; PLASMA;
   DIET; INFLAMMATION; DISEASE; ASSOCIATION; CHOLESTEROL; GLUTATHIONE
AB Background: Oxidative stress is known to play a role in the pathophysiology of metabolic syndrome and its components. Racial differences may exist in the level of markers of oxidative stress and antioxidants in patients with metabolic syndrome. Aim: The aim of this study was to determine the oxidative stress and antioxidants status in subjects with metabolic syndrome in Sokoto, North-Western Nigeria. Methods: A cross-sectional community-based study was carried out. Two hundred subjects (96 males and 104 females) were recruited for the study using a multi-stage sampling technique. Demographic data were obtained from the participants. Evaluation of anthropometric variables, blood pressure, blood glucose levels, lipid profiles, plasma insulin levels, total antioxidant status, and oxidative stress markers was performed. Results: The subjects with metabolic syndrome had significantly higher malondialdehyde as compared to those without metabolic syndrome (236.4 [92.2] vs. 184 [63.2] nmol/l). The antioxidant enzymes (superoxide dismutase, glutathione peroxidase and catalase) were significantly lower in subjects with metabolic syndrome than in those without metabolic syndrome (11.3 [4.2] vs. 13.9 [4.1] U/ml, 160[42] vs. 220[32] U/ml, and 2.12 [0.2] vs. 2.42 [0.2] U/ml, respectively). Similarly, the antioxidant Vitamins (A, C, and E) levels were significantly lower in subjects with metabolic syndrome than in those without metabolic syndrome (7.1 [4.1] vs. 7.7 [4.2] mol/L, 225 [55.3] vs. 227.6 [62.3] mol/L, and 75.9 [13.9] vs. 82.8 [18.6] mg/dl, respectively). There was a positive correlation between components of metabolic syndrome and free radicals. Conclusion: Significantly increased oxidative stress and diminished antioxidant defenses were found among Nigerians with metabolic syndrome.
C1 [Sabir, A. A.; Isezuo, S. A.] Usmanu Danfodiyo Univ, Teaching Hosp, Dept Med, Sokoto, Nigeria.
   [Kaoje, A. U.] Usmanu Danfodiyo Univ, Teaching Hosp, Dept Community Hlth, Sokoto, Nigeria.
   [Bilbis, L. S.; Saidu, Y.] Usmanu Danfodiyo Univ, Dept Biochem, Sokoto, Nigeria.
   [Jimoh, A.] Usmanu Danfodiyo Univ, Dept Pharmacol, Sokoto, Nigeria.
   [Iwuala, S. O.] Univ Lagos, Teaching Hosp, Dept Med, Lagos, Nigeria.
   [Abubakar, S. A.] Ahmadu Bello Univ, Teaching Hosp, Dept Med, Zaria, Nigeria.
C3 University of Lagos; Ahmadu Bello University
RP Sabir, AA (corresponding author), Usmanu Danfodiyo Univ, Teaching Hosp, Dept Med, Sokoto, Nigeria.
EM ansabir1@yahoo.com
RI Jimoh, Abdulgafar/ABH-8200-2020
OI Jimoh, Abdulgafar O./0000-0002-7322-9100; Sabir,
   Anas/0000-0003-4157-1347; Abubakar, Sani Atta/0000-0002-5013-0706
FU Tertiary Education Trust Fund, Zambezi Crescent, Off Aguiyi Ironsi
   Street, Maitama Abuja, Nigeria
FX This work was supported by research grant from Tertiary Education Trust
   Fund, No. 6, Zambezi Crescent, Off Aguiyi Ironsi Street, Maitama Abuja,
   Nigeria.
CR [Anonymous], FEDERAL REPUBLIC NIG
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NR 33
TC 14
Z9 15
U1 0
U2 3
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, 400059, INDIA
SN 1119-3077
J9 NIGER J CLIN PRACT
JI Niger. J. Clin. Pract.
PD JAN-FEB
PY 2016
VL 19
IS 1
BP 128
EP 132
DI 10.4103/1119-3077.173705
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA DH5LN
UT WOS:000372830600020
PM 26755231
DA 2025-06-11
ER

PT J
AU Mukherjee, A
   Sen, KK
   Banerjee, S
AF Mukherjee, Aniruddha
   Sen, Kalyan K.
   Banerjee, Sugato
TI Effect of Metabolic Syndrome on Depression in Mice
SO INDIAN JOURNAL OF PHARMACEUTICAL EDUCATION AND RESEARCH
LA English
DT Article
DE Depression; Dopamine; Metabolic syndrome; Norepinephrine; Obesity;
   Serotonin; Type 2 Diabetes
ID DIABETES-MELLITUS; INTERLEUKIN-6 LEVELS; OBESITY; BDNF; STRESS;
   SCHIZOPHRENIA; ASSOCIATION; ANTIDEPRESSANTS; HYPERTENSION; NEUROPEPTIDE
AB Metabolic syndrome (MetS) is associated with high blood glucose, insulin resistance, dyslipidemia, central obesity, and hypertension. There is clinical evidence of the coexistence of depression and MetS, however, pathways associating these diseases are far from clear. In the present study, we evaluate and determine the pathogenesis of depression in MetS animals. Methods: Diet induced (High-fat diet long with 20% fructose water; HFHC diet for 4 weeks) MetS was developed in swiss albino mice. Fasting blood glucose levels, Lipids and blood pressure (BP) was measured in these animals. Development of depression in these animals was determined using forced swim and tail suspension tests. This was followed by measurement of GABA, dopamine, serotonin and norepinephrine levels in these animals. We also evaluated the effect of various antidepressants, on MetS associated depression. Results: MetS was induced using high fat and high carbohydrate (HFHC) diet in Swiss albino mice with high fasting blood glucose levels (> 250 mg/dl), significantly increased LDL (p < 0.001) and triglyceride (p < 0.01) and reduced HDL levels (p < 0.05) and significant increase in systolic BP; p < 0.001) compared to normal controls. MetS animals showed signs of depression with significantly higher (p < 0.001) immobility time in forced swim and tail suspension tests. These animals showed significantly lower corticohippocampal norepinephrine (NE) levels (p < 0.01) compared to controls. Nortryptaline, showed a dose dependent decrease in immobility time in MetS animals (p < 0.001) in both forced swim and tail suspension tests thus reversing MetS induced depression. Conclusion: The above results suggest that MetS may lead to depression in mice which is primarily mediated by NE system.
C1 [Mukherjee, Aniruddha; Sen, Kalyan K.] Gupta Coll Technol Sci, Dept Pharmacol, Asansol, W Bengal, India.
   [Banerjee, Sugato] Birla Inst Technol, Dept Pharmaceut Sci & Technol, Ranchi 835215, Bihar, India.
C3 Birla Institute of Technology Mesra
RP Banerjee, S (corresponding author), Birla Inst Technol, Dept Pharmaceut Sci & Technol, Ranchi 835215, Bihar, India.
EM sbanerjee@bitmesra.ac.in
RI Sen, Kalyan/F-2048-2017; Mukherjee, Aniruddha/S-7889-2019; BANERJEE,
   SUGATO/L-9012-2019; BANERJEE, SUGATO/M-7317-2017
OI Mukherjee, Aniruddha/0009-0005-8397-6061; sen, kalyan
   kumar/0000-0003-1914-9238; BANERJEE, SUGATO/0000-0002-4402-3066
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NR 53
TC 2
Z9 2
U1 2
U2 4
PU ASSOC PHARMACEUTICAL TEACHERS INDIA
PI BANGALORE
PA AL-AMEEN COLL PHARMACY, OPP LALBACH MAIN GATE, HOSUR MAIN RD, BANGALORE,
   560 027, INDIA
SN 0019-5464
J9 INDIAN J PHARM EDUC
JI Indian J. Pharm. Educ. Res.
PD OCT-DEC
PY 2017
VL 51
IS 4
SU S
BP S645
EP S652
DI 10.5530/ijper.51.4s.94
PG 8
WC Education, Scientific Disciplines; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Education & Educational Research; Pharmacology & Pharmacy
GA GJ2ZT
UT WOS:000435144400016
OA hybrid, Green Submitted
DA 2025-06-11
ER

PT J
AU Amagasa, S
   Machida, M
   Fukushima, N
   Kikuchi, H
   Takamiya, T
   Odagiri, Y
   Inoue, S
AF Amagasa, Shiho
   Machida, Masaki
   Fukushima, Noritoshi
   Kikuchi, Hiroyuki
   Takamiya, Tomoko
   Odagiri, Yuko
   Inoue, Shigeru
TI Is objectively measured light-intensity physical activity associated
   with health outcomes after adjustment for moderate-to-vigorous physical
   activity in adults? A systematic review
SO INTERNATIONAL JOURNAL OF BEHAVIORAL NUTRITION AND PHYSICAL ACTIVITY
LA English
DT Review
DE Accerelometry; Epidemiology; Public health; Lifestyle activity; Physical
   activity
ID SEDENTARY TIME; METABOLIC SYNDROME; NATIONAL-HEALTH; LIPOPROTEIN-LIPASE;
   RISK; ACCELEROMETER; MORTALITY; BEHAVIOR; NHANES; BIOMARKERS
AB Background: An increasing number of studies have demonstrated that light-intensity physical activity (LPA) confers health benefits after adjustment for moderate-to-vigorous physical activity (MVPA). The purpose of this systematic review was to summarize existing epidemiological evidence on associations of objectively measured LPA with health outcomes in adults.
   Methods: This review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. We searched on PubMed, Web of Science, CINAL, and Cochrane Library for articles analyzing the association between objectively determined LPA and health outcomes that were published up to January 2017. Data were extracted regarding authors, publication year, country of survey, study setting, number of participants, study design, physical activity (PA) assessment (type of accelerometer and intensity), health outcomes, confounders, and results (summary measures and association). A coding system was used to summarize the results.
   Results: Of the 3254 studies identified, 24 cross-sectional and 6 longitudinal studies were included in this review. Most of the studies targeted the Western population. LPA was inversely associated with all-cause mortality risk and associated favorably with some cardiometabolic risk factors including waist circumference, triglyceride levels, insulin, and presence of metabolic syndrome. Only a small amount of data were available on mental health and cognitive function.
   Conclusions: LPA appears to be beneficially associated with important health outcomes after adjustment for MVPA in the adult population. Although current global PA guidelines recommend only MVPA, promoting LPA may confer additional health benefits.
C1 [Amagasa, Shiho; Machida, Masaki; Fukushima, Noritoshi; Kikuchi, Hiroyuki; Takamiya, Tomoko; Odagiri, Yuko; Inoue, Shigeru] Tokyo Med Univ, Dept Prevent Med & Publ Hlth, Tokyo, Japan.
C3 Tokyo Medical University
RP Inoue, S (corresponding author), Tokyo Med Univ, Dept Prevent Med & Publ Hlth, Tokyo, Japan.
EM inoue@tokyo-med.ac.jp
RI Amagasa, Shiho/LYO-5109-2024
OI Machida, Masaki/0000-0002-7060-7305; Amagasa, Shiho/0000-0002-6047-0771;
   Odagiri, Yuko/0000-0002-7603-4800
FU Japan Ministry of Education, Culture, Sports, Science and Technology
   [16H03249]; MEXT-Supported Program for the Strategic Research Foundation
   at Private Universities; Ministry of Education, Culture, Sports, Science
   and Technology [S1511017]; Grants-in-Aid for Scientific Research
   [16H03249] Funding Source: KAKEN
FX This study was supported by a Grant-in-Aid for Scientific Research from
   the Japan Ministry of Education, Culture, Sports, Science and Technology
   (16H03249), and MEXT-Supported Program for the Strategic Research
   Foundation at Private Universities, 2015-2019 from the Ministry of
   Education, Culture, Sports, Science and Technology (S1511017).
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NR 56
TC 145
Z9 161
U1 6
U2 66
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1479-5868
J9 INT J BEHAV NUTR PHY
JI Int. J. Behav. Nutr. Phys. Act.
PD JUL 9
PY 2018
VL 15
AR 65
DI 10.1186/s12966-018-0695-z
PG 13
WC Nutrition & Dietetics; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics; Physiology
GA GM2UI
UT WOS:000437947600002
PM 29986718
OA Green Published, gold
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Mezick, EJ
   Hall, M
   Matthews, KA
AF Mezick, Elizabeth J.
   Hall, Martica
   Matthews, Karen A.
TI Are sleep and depression independent or overlapping risk factors for
   cardiometabolic disease?
SO SLEEP MEDICINE REVIEWS
LA English
DT Review
DE Sleep duration; Sleep continuity; Depression; Cardiovascular disease;
   Diabetes; Metabolic syndrome; Mechanisms
ID SELF-REPORTED SLEEP; CORONARY-HEART-DISEASE; MIDDLE-AGED MEN;
   CARDIOVASCULAR-DISEASE; PSYCHOLOGICAL DISTRESS; INCIDENT HYPERTENSION;
   GENERAL-POPULATION; METABOLIC SYNDROME; OLDER-ADULTS; DURATION
AB Sleep duration, sleep continuity, and depression are associated with cardiovascular disease and metabolic disorders. Despite the well-established relationship between sleep and depression, few studies examine these characteristics simultaneously in the development of cardiometabolic disease. Here, we review available studies that include measures of both sleep and depression in relation to cardiometabolic outcomes (cardiovascular disease, diabetes, and the metabolic syndrome). In general, data show that independent of depression, sleep continuity is a risk factor for cardiovascular disease, and short or long sleep duration is a risk factor for diabetes and the metabolic syndrome. Results for associations between sleep duration and cardiovascular disease, and associations between sleep continuity and metabolic disease, are more mixed. Regarding depression, there is preliminary evidence that depression increases risk for cardiovascular disease, independent of sleep continuity. However, there are insufficient data to address whether relationships between depression and cardiovascular and metabolic disease are independent of sleep duration. A number of biobehavioral mechanisms, including inflammation, hypothalamic and sympathetic dysregulation, and obesity and health behaviors, may account for the relationships among sleep, depression, and cardiometabolic disease. After summarizing these mechanisms, we discuss limitations of the extant literature and suggest directions for future research. (C) 2010 Elsevier Ltd. All rights reserved.
C1 [Matthews, Karen A.] Univ Pittsburgh, Sch Med, Dept Psychiat, Pittsburgh, PA 15213 USA.
   [Hall, Martica] Western Psychiat Inst & Clin, Dept Psychiat, Pittsburgh, PA 15213 USA.
   [Mezick, Elizabeth J.] Univ Pittsburgh, Dept Psychol, Pittsburgh, PA 15213 USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE); University
   of Pittsburgh; Pennsylvania Commonwealth System of Higher Education
   (PCSHE); University of Pittsburgh; Western Psychiatric Institute &
   Clinic of UPMC; Pennsylvania Commonwealth System of Higher Education
   (PCSHE); University of Pittsburgh
RP Matthews, KA (corresponding author), Univ Pittsburgh, Sch Med, Dept Psychiat, 3811 OHara St, Pittsburgh, PA 15213 USA.
EM mezickej@upmc.edu; hallmh@upmc.edu; matthewska@upmc.edu
RI ; Hall, Martica/D-2809-2012
OI Pantesco, Elizabeth/0000-0002-0947-112X; Hall,
   Martica/0000-0003-0642-2098
FU National Institutes of Health, Bethesda, MD [AG019362, RR024153,
   HL076379, HL065111, HL065112, R24 HL076852, HL076858, HL07560]
FX This research was supported by grants AG019362, RR024153, HL076379,
   HL065111, HL065112, R24 HL076852, HL076858, and HL07560 from the
   National Institutes of Health, Bethesda, MD.
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NR 83
TC 67
Z9 75
U1 3
U2 29
PU W B SAUNDERS CO LTD
PI LONDON
PA 32 JAMESTOWN RD, LONDON NW1 7BY, ENGLAND
SN 1087-0792
EI 1532-2955
J9 SLEEP MED REV
JI Sleep Med. Rev.
PD FEB
PY 2011
VL 15
IS 1
BP 51
EP 63
DI 10.1016/j.smrv.2010.03.001
PG 13
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 720HN
UT WOS:000287271600007
PM 20494595
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Yoo, HL
   Eisenmann, JC
   Franke, WD
AF Yoo, Hye Lim
   Eisenmann, Joey C.
   Franke, Warren D.
TI Independent and Combined Influence of Physical Activity and Perceived
   Stress on the Metabolic Syndrome in Male Law Enforcement Officers
SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
LA English
DT Article
ID CARDIOVASCULAR-DISEASE MORBIDITY; RISK-FACTORS; CARDIORESPIRATORY
   FITNESS; POLICE OFFICERS; EXERCISE; PREVALENCE; ADULTS; SCORE; MEN;
   ASSOCIATION
AB Objective: To examine the independent and combined interrelationships among physical activity, perceived stress, and the metabolic syndrome in law enforcement officers (LEOs). Methods: Perceived stress, self-reported physical activity, and metabolic syndrome risk factors were assessed in 386 white mate LEOs. Results: Among the LEOs, 23.1% had the metabolic syndrome. The metabolic syndrome was not significantly associated with perceived stress (r = 0.047) whereas physical activity was (r = -0.225, P < 0.0001). The odds ratios (95% CI) fir possessing the metabolic syndrome in the low and moderate physical activity groups compared to the high physical activity group were 3.13 (95% CI = 1.56 to 6.26) and 2.30 (95% CI = 1.29 to 4.09), respectively. Conclusions: Regardless of stress level, physical inactivity is an important risk factor in the metabolic syndrome among this unique occupational group. (J Occup Environ Med. 2009;51:46-53)
C1 [Yoo, Hye Lim; Franke, Warren D.] Iowa State Univ, Dept Kinesiol, Ames, IA USA.
   [Eisenmann, Joey C.] Michigan State Univ, Dept Kinesiol, E Lansing, MI 48824 USA.
C3 Iowa State University; Michigan State University
RP Franke, WD (corresponding author), 247 Forker Bldg, Ames, IA 50011 USA.
EM wfranke@iastate.edu
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NR 49
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U1 0
U2 13
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1076-2752
EI 1536-5948
J9 J OCCUP ENVIRON MED
JI J. Occup. Environ. Med.
PD JAN
PY 2009
VL 51
IS 1
BP 46
EP 53
DI 10.1097/JOM.0b013e31817f9e43
PG 8
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA 394NB
UT WOS:000262452300008
PM 19136873
DA 2025-06-11
ER

PT J
AU Williams, J
   Stubbs, B
   Richardson, S
   Flower, C
   Barr-Hamilton, L
   Grey, B
   Hubbard, K
   Spaducci, G
   Gaughran, F
   Craig, T
AF Williams, Julie
   Stubbs, Brendon
   Richardson, Sol
   Flower, Cathy
   Barr-Hamilton, Lucy
   Grey, Barbara
   Hubbard, Kathryn
   Spaducci, Gilda
   Gaughran, Fiona
   Craig, Tom
TI 'Walk this way': results from a pilot randomised controlled trial of a
   health coaching intervention to reduce sedentary behaviour and increase
   physical activity in people with serious mental illness
SO BMC PSYCHIATRY
LA English
DT Article
DE Sedentary behaviour; Physical activity; Serious mental illness;
   Psychosis; Metabolic syndrome
ID MAJOR DEPRESSIVE DISORDER; METABOLIC SYNDROME; BIPOLAR DISORDER;
   CARDIOVASCULAR-DISEASE; WEIGHT-LOSS; SCHIZOPHRENIA; MORTALITY;
   METAANALYSIS; RISK; CARE
AB Background Cardiovascular disease (CVD) is the leading cause of premature death among people with serious mental illness (SMI). Sedentary behaviour (SB) is an independent risk factor for CVD and mortality and people with SMI are highly sedentary. We developed a health coaching intervention called 'Walk this Way' to reduce SB and increase physical activity (PA) in people with SMI and conducted a pilot randomised controlled trial (RCT) to test its feasibility and acceptability. Methods We randomised people with SMI from three community mental health teams into either the WTW intervention or treatment as usual. The WTW intervention lasted 17 weeks and included an initial education session, fortnightly coaching, provision of pedometers and access to a weekly walking group. Objective SB and PA were measured with accelerometers. Cardiometabolic risk factors and wellbeing measures were collected. Results We recruited 40 people of whom 33 (82.5%) were followed up. 13/20 (65%) of participants allocated to the coaching intervention completed it. In the intervention group SB decreased by 56 min and total PA increased by 32 min per day on average which was sustained 6 months later. There was no change in PA or SB in the control group. When interviewed, participants in the intervention found the intervention helpful and acceptable. No adverse events were reported from the intervention. Conclusions The intervention was feasible and acceptable to participants. Preliminary results were encouraging with improvement seen in both SB and PA. A larger study is needed to assess the effectiveness of the intervention and address any implementation challenges.
C1 [Williams, Julie; Stubbs, Brendon; Hubbard, Kathryn; Spaducci, Gilda; Gaughran, Fiona; Craig, Tom] Kings Coll London, Inst Psychiat Psychol & Neurosci, Hlth Serv & Populat Res Dept, London, England.
   [Stubbs, Brendon] South London & Maudsley NHS Fdn Trust, Physiotherapy Dept, London, England.
   [Stubbs, Brendon; Gaughran, Fiona] Kings Coll London, Inst Psychiat Psychol & Neurosci, Psychosis Studies, London, England.
   [Richardson, Sol] Kings Coll London, Inst Psychiat Psychol & Neurosci, Addict Dept, London, England.
   [Richardson, Sol] UK Ctr Tobacco & Alcohol Studies, Nottingham, England.
   [Flower, Cathy; Barr-Hamilton, Lucy; Grey, Barbara] South London & Maudsley NHS Fdn Trust, Psychosis Clin Acad Grp, London, England.
   [Gaughran, Fiona] South London & Maudsley NHS Fdn Trust, Natl Psychosis Serv, London, England.
C3 University of London; King's College London; South London & Maudsley NHS
   Trust; University of London; King's College London; University of
   London; King's College London; South London & Maudsley NHS Trust; South
   London & Maudsley NHS Trust
RP Williams, J (corresponding author), Kings Coll London, Inst Psychiat Psychol & Neurosci, Hlth Serv & Populat Res Dept, London, England.
EM julie.williams@kcl.ac.uk
RI Stubbs, Brendon/X-1904-2018; Gaughran, Fiona/AAC-7160-2019; Williams,
   Julie/JYQ-5874-2024; Stubbs, Brendon/C-5696-2015; Gaughran,
   Fiona/H-5495-2011
OI Stubbs, Brendon/0000-0001-7387-3791; Spaducci,
   Gilda/0000-0003-1343-2622; Gaughran, Fiona/0000-0001-7414-5569
FU Maudsley Charity; National Institute for Health Research (NIHR)
   Collaboration for Leadership in Applied Health Research and Care South
   London (NIHR CLAHRC South London) at King's College Hospital NHS
   Foundation Trust; Health Education England; National Institute for
   Health Research HEE/NIHR ICA Programme Clinical Lectureship
   [ICA-CL-2017-03-001]
FX This research was supported by the Maudsley Charity and the National
   Institute for Health Research (NIHR) Collaboration for Leadership in
   Applied Health Research and Care South London (NIHR CLAHRC South London)
   at King's College Hospital NHS Foundation Trust. BS is supported by
   Health Education England and the National Institute for Health Research
   HEE/NIHR ICA Programme Clinical Lectureship (ICA-CL-2017-03-001). No
   funding source had any role in the design and conduct of the study;
   collection, management, analysis or interpretation of the data; or
   preparation, review or approval of the manuscript. The views expressed
   are those of the author(s) and not necessarily those of the NHS, the
   NIHR or the Department of Health and Social Care.
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NR 41
TC 25
Z9 27
U1 1
U2 13
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-244X
J9 BMC PSYCHIATRY
JI BMC Psychiatry
PD SEP 18
PY 2019
VL 19
IS 1
AR 287
DI 10.1186/s12888-019-2274-5
PG 10
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA IY9OP
UT WOS:000486723000004
PM 31533686
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Guler, E
   Guler, GB
   Kizilirmak, F
   Batgerel, U
   Demir, GG
   Gunes, HM
   Karaca, O
   Ozcan, O
   Barutcu, I
   Turkmen, MM
   Esen, AM
AF Guler, E.
   Guler, G. B.
   Kizilirmak, F.
   Batgerel, U.
   Demir, G. G.
   Gunes, H. M.
   Karaca, O.
   Ozcan, O.
   Barutcu, I.
   Turkmen, M. M.
   Esen, A. M.
TI Evaluation of adiponectin and lipoprotein(a) levels in cardiac syndrome
   X
SO HERZ
LA English
DT Article
DE Adiponectin; Lipoprotein(a); Cardiac syndrome X; Microvascular injury;
   Etiopathogenesis
ID NORMAL CORONARY-ARTERIES; INTERNATIONAL-DIABETES-FEDERATION; METABOLIC
   SYNDROME; CHEST-PAIN; INSULIN-RESISTANCE; CARDIOVASCULAR-DISEASE;
   ANGINA; ATHEROSCLEROSIS; PROTEIN; HEART
AB Aims. Low adiponectin and high lipoprotein(a) [Lp(a)] levels are associated with endothelial dysfunction, atherosclerosis, and coronary artery disease. Cardiac syndrome X (CSX) is characterized by anginal symptoms, positive stress test, and documentation of normal epicardial coronary arteries with angiography. In this study we aimed to investigate the relationship between CSX and circulating levels of adiponectin and Lp(a).
   Patients and methods. We enrolled 53 female patients with CSX and 33 patients as the control group. The diagnosis of CSX was made according to presence of angina, findings suggestive of ischemia during stress electrocardiography or myocardial perfusion scintigraphy, and documentation of normal coronary arteries in coronary angiography. The control group consisted of patients with atypical angina and normal stress electrocardiography test results. Both groups were matched in terms of hypertension, diabetes mellitus, and metabolic syndrome.
   Results. Adiponectin levels were significantly decreased in patients with CSX (4.57 mu g/ml vs. 13.18 mu g/ml; p=0.001); however, Lp(a) levels were significantly increased (36.30 mg/dl vs. 7.24 mg/dl; p<0.001). Low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglycerides (TG) concentrations did not differ between the case group and the control group (p=0.14, p=0.62, p=0.64, respectively). There was no significant difference between groups in terms of age, body mass index, waist circumference hypertension, hyperlipidemia, diabetes mellitus, or metabolic syndrome. In multivariate analysis, Lp(a) and adiponectin were found to be independent predictors of CSX. An Lp(a) level of >21 mg/dl had 84% sensitivity and 96% specificity {area under the curve (AUC)=0.922, p<0.0001, 95% CI [0.842-0.970]} and an adiponectin level of <= 5.18 mu g/ml also had 58.7% sensitivity and 82.1% specificity (AUC=0.726, p=0.0003, 95% CI [ 0.609-0.823]) for detecting CSX.
   Conclusion. We detected low adiponectin and high Lp(a) levels in patients with CSX and these findings may be related to the microvascular injury in CSX.
C1 [Guler, E.; Guler, G. B.; Kizilirmak, F.; Batgerel, U.; Demir, G. G.; Gunes, H. M.; Karaca, O.; Barutcu, I.; Turkmen, M. M.] Medipol Univ, Dept Cardiol, Fac Med, Medipol Univ Hosp, TR-34214 Istanbul, Turkey.
   [Ozcan, O.] GATA Haydarpasa Res Hosp, Dept Biochem, Istanbul, Turkey.
   [Esen, A. M.] Kartal Kosuyolu Heart Res & Educ Hosp, Dept Cardiol, Istanbul, Turkey.
C3 Medipol Hospital; Istanbul Medipol University; Istanbul Haydarpasa
   Sultan Abdulhamid Training & Research Hospital; Gulhane Military Medical
   Academy; Istanbul Kartal Kosuyolu Yuksek Ihtisas Training & Research
   Hospital
RP Guler, E (corresponding author), Medipol Univ, Dept Cardiol, Fac Med, Medipol Univ Hosp, TEM Avrupa Otoyolu Goztepe Cikisi 1, TR-34214 Istanbul, Turkey.
EM ekgul@yahoo.com
RI güler, ekrem/HLQ-1313-2023; Demir, Gültekin/U-3716-2018; TURKMEN,
   MEHMET/IWD-9632-2023
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NR 42
TC 10
Z9 10
U1 0
U2 4
PU URBAN & VOGEL
PI MUNICH
PA NEUMARKTER STRASSE 43, D-81673 MUNICH, GERMANY
SN 0340-9937
EI 1615-6692
J9 HERZ
JI Herz
PD MAY
PY 2015
VL 40
SU 3
BP 291
EP 297
DI 10.1007/s00059-014-4191-1
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA CT1NO
UT WOS:000362565500013
PM 25676008
DA 2025-06-11
ER

PT J
AU Chen, E
   Yu, TY
   Miller, GE
   Brody, GH
AF Chen, Edith
   Yu, Tianyi
   Miller, Gregory E.
   Brody, Gene H.
TI Substance Use and Obesity Trajectories in African Americans Entering
   Adulthood
SO AMERICAN JOURNAL OF PREVENTIVE MEDICINE
LA English
DT Article
ID C-REACTIVE PROTEIN; METABOLIC SYNDROME; NUCLEUS-ACCUMBENS; CHRONIC
   STRESS; ALCOHOL-USE; RISK; DEPRESSION; ADDICTION; BEHAVIORS; ANTECEDENTS
AB Introduction: The transition to adulthood can be stressful for minority adolescents, and many may cope through unhealthy behaviors, including substance use and obesity-related behaviors. This study tested substance use and obesity trajectories over time in African American youth, longitudinal associations of trajectories with mental and physical health in adulthood, and whether self-control and sex predict trajectories.
   Methods: Two longitudinal studies of 516 and 992 African American adolescents. In Study 1, substance use and obesity trajectories were assessed from ages 19 to 25 years. At age 25 years, internalizing and externalizing problems, metabolic syndrome, and inflammatory biomarkers were measured. In Study 2, substance use and obesity trajectories were assessed from ages 17 to 29 years. Depression, delinquency, diabetes, blood pressure, and inflammatory biomarkers were measured at age 29 years. Data analyses were conducted in 2017.
   Results: Across both studies, the majority of African American adolescents evinced poor health behavior trajectories (latent class growth analyses), with 23%-27% showing increasing substance use over time, 18%-27% showing increasing obesity over time, and 9%-11% showing increases in both. ANCOVAs for trajectory analyses revealed that males were more likely to evince increasing substance use, with females more likely to show increasing obesity. Substance use trajectories were associated with poorer mental health in adulthood; obesity trajectories with poorer physical health in adulthood. Those with good health behavior trajectories had higher self-control in early adolescence.
   Conclusions: The transition to adulthood is a vulnerable period for many African Americans. Given the commonalities of substance use and obesity in their rewarding/stress-relieving properties, similar prevention efforts may help stem the rise of both in these youth. (C) 2018 American Journal of Preventive Medicine. Published by Elsevier Inc. All rights reserved.
C1 [Chen, Edith; Miller, Gregory E.] Northwestern Univ, Inst Policy Res, 2029 Sheridan Rd, Evanston, IL 60208 USA.
   [Chen, Edith; Miller, Gregory E.] Northwestern Univ, Dept Psychol, 2029 Sheridan Rd, Evanston, IL 60208 USA.
   [Yu, Tianyi; Brody, Gene H.] Univ Georgia, Ctr Family Res, Athens, GA 30602 USA.
C3 Northwestern University; Northwestern University; University System of
   Georgia; University of Georgia
RP Chen, E (corresponding author), Northwestern Univ, Inst Policy Res, 2029 Sheridan Rd, Evanston, IL 60208 USA.; Chen, E (corresponding author), Northwestern Univ, Dept Psychol, 2029 Sheridan Rd, Evanston, IL 60208 USA.
EM edith.chen@northwestern.edu
OI Miller, Gregory/0000-0002-7217-1082; Yu, Tianyi/0000-0003-3087-1504
FU National Institute of Child Health and Human Development [R01 HD030588];
   National Institute on Drug Abuse [P30 DA027827]
FX This research was supported by grants from the National Institute of
   Child Health and Human Development (R01 HD030588) and National Institute
   on Drug Abuse (P30 DA027827).
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NR 56
TC 8
Z9 11
U1 1
U2 2
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0749-3797
EI 1873-2607
J9 AM J PREV MED
JI Am. J. Prev. Med.
PD DEC
PY 2018
VL 55
IS 6
BP 856
EP 863
DI 10.1016/j.amepre.2018.07.004
PG 8
WC Public, Environmental & Occupational Health; Medicine, General &
   Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; General & Internal Medicine
GA HD8CL
UT WOS:000452781800013
PM 30337234
OA Bronze, Green Accepted
DA 2025-06-11
ER

PT J
AU Moreira, MCD
   Pinto, ISD
   Mourao, AA
   Fajemiroye, JO
   Colombari, E
   Reis, AAD
   Freiria-Oliveira, AH
   Ferreira-Neto, ML
   Pedrino, GR
AF dos Santos Moreira, Marina C.
   de Jesus Pinto, Izabella S.
   Mourao, Aline A.
   Fajemiroye, James O.
   Colombari, Eduardo
   da Silva Reis, Angela A.
   Freiria-Oliveira, Andre H.
   Ferreira-Neto, Marcos L.
   Pedrino, Gustavo R.
TI Does the sympathetic nervous system contribute to the pathophysiology of
   metabolic syndrome?
SO FRONTIERS IN PHYSIOLOGY
LA English
DT Review
DE obesity; insulin resistance; hypertension; cardiovascular diseases;
   central nervous system
ID TUMOR-NECROSIS-FACTOR; SPONTANEOUSLY HYPERTENSIVE-RATS;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; ADIPOSE-TISSUE; BLOOD-PRESSURE;
   DIASTOLIC DYSFUNCTION; VASCULAR INFLAMMATION; LEPTIN RESISTANCE; OBESITY
AB The metabolic syndrome (MS), formally known as syndrome X, is a clustering of several risk factors such as obesity, hypertension, insulin resistance, and dislypidemia which could lead to the development of diabetes and cardiovascular diseases (CVD). The frequent changes in the definition and diagnostic criteria of MS are indications of the controversy and the challenges surrounding the understanding of this syndrome among researchers. Obesity and insulin resistance are leading risk factors of MS. Moreover, obesity and hypertension are closely associated to the increase and aggravation of oxidative stress. The recommended treatment of MS frequently involves change of lifestyles to prevent weight gain. MS is not only an important screening tool for the identification of individuals at high risk of CVD and diabetes but also an indicator of suitable treatment. As sympathetic disturbances and oxidative stress are often associated with obesity and hypertension, the present review summarizes the role of sympathetic nervous system and oxidative stress in the MS.
C1 [dos Santos Moreira, Marina C.; de Jesus Pinto, Izabella S.; Mourao, Aline A.; Freiria-Oliveira, Andre H.; Pedrino, Gustavo R.] Univ Fed Goias, Dept Physiol Sci, Ctr Neurosci & Cardiovasc Res, BR-74001970 Goiania, Go, Brazil.
   [Fajemiroye, James O.] Univ Fed Goias, Lab Pharmacol & Nat Prod, BR-74001970 Goiania, Go, Brazil.
   [Colombari, Eduardo] Univ Estadual Paulista, Sch Dent, Dept Physiol & Pathol, Araraquara, Brazil.
   [da Silva Reis, Angela A.] Univ Fed Goias, Dept Biochem & Mol Biol, BR-74001970 Goiania, Go, Brazil.
   [Ferreira-Neto, Marcos L.] Univ Fed Uberlandia, Fac Phys Educ, Lab Expt Physiol, BR-38400 Uberlandia, MG, Brazil.
C3 Universidade Federal de Goias; Universidade Federal de Goias;
   Universidade Estadual Paulista; Universidade Federal de Goias;
   Universidade Federal de Uberlandia
RP Pedrino, GR (corresponding author), Univ Fed Goias, Dept Physiol Sci, Estrada Campus S-N,POB 131, BR-74001970 Goiania, Go, Brazil.
EM pedrino@pq.cnpq.br
RI Mourao, Aline/NKP-3707-2025; Ferreira-Neto, Marcos/AHC-8135-2022; DA
   SILVA, ANGELA/AAJ-1403-2021; Freiria-Oliveira, Andre/F-2756-2012;
   Ferreira-Neto, Marcos Luiz/O-3368-2014; Fajemiroye, James
   Oluwagbamigbe/E-8626-2016; R. Pedrino, Gustavo/I-5614-2015; Colombari,
   Eduardo/C-3044-2012
OI Andrade Mourao, Aline/0000-0002-6289-7293; Freiria-Oliveira, Andre
   Henrique/0000-0002-7511-5035; Ferreira-Neto, Marcos
   Luiz/0000-0002-9695-7100; Fajemiroye, James
   Oluwagbamigbe/0000-0001-7440-7581; R. Pedrino,
   Gustavo/0000-0003-0488-5400; Colombari, Eduardo/0000-0002-1395-4036
FU Fundacao de Amparo a Pesquisa do Estado de Goias (FAPEG); Conselho
   Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
FX This work was supported by Fundacao de Amparo a Pesquisa do Estado de
   Goias (FAPEG) and by Conselho Nacional de Desenvolvimento Cientifico e
   Tecnologico (CNPq).
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NR 139
TC 44
Z9 47
U1 0
U2 8
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-042X
J9 FRONT PHYSIOL
JI Front. Physiol.
PD AUG 25
PY 2015
VL 6
AR 234
DI 10.3389/fphys.2015.00234
PG 11
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA CQ3BL
UT WOS:000360476500001
PM 26379553
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Pogodina, A
   Rychkova, L
   Kravtzova, O
   Klimkina, J
   Kosovtzeva, A
AF Pogodina, Anna
   Rychkova, Ljubov
   Kravtzova, Olga
   Klimkina, Juliana
   Kosovtzeva, Arjuna
TI Cardiometabolic Risk Factors and Health-Related Quality of Life in
   Adolescents with Obesity
SO CHILDHOOD OBESITY
LA English
DT Article
DE adolescents; cardiometabolic risk; health-related quality of life;
   metabolic syndrome; obesity
ID PHYSICAL-ACTIVITY; OVERWEIGHT; CHILDREN; DEPRESSION; ADIPOSITY; IMPACT
AB Background: A number of research studies have demonstrated a decrease in health-related quality of life (HRQL) measures among obese children. Moreover, the causes of HRQL impairments are not completely clear. Adolescent obesity is oftentimes associated with other cardiometabolic risk factors (CRFs); hence, the aim of our research was to estimate the frequency of CRFs and to determine whether there is an association between CRFs and HRQL scores among obese adolescents.
   Methods: Our research included 92 treatment-seeking obese adolescents (11-17 years), 34 males. We looked at medical records and performed physical examinations, including anthropometry and laboratory evaluations. PedsQL (TM) 4.0 was used to assess the HRQL score. Logistic regression models were used to identify CRFs associated with worse HRQL scores, both in total and in each domain.
   Results: The vast majority (70.6%) of adolescents had at least one CRF in addition to obesity. A cluster of three to four CRFs was found in 23.3% and was associated with males more than with the degree of obesity [odds ratio (OR) 4; confidence interval (95% CI) 1.3-11.6, p = 0.01]. HRQL scores in emotional functioning domain and scores of HRQL total were directly associated with waist circumference Z-score (OR 4.1; 95% CI 1.1-14.9, p = 0.03 and OR 3.4; 95% CI 1-11.6, p = 0.049). Hypertension was associated with worsening HRQL scores in school functioning domain (OR 3.3; 95% CI 1-10.9, p = 0.049).
   Conclusion: Obesity in adolescents is associated with a high frequency of associated CRFs and decreased HRQL scores. Although CRFs have an influence on reducing adolescents' HRQL, they are not a determining factor.
C1 [Pogodina, Anna; Rychkova, Ljubov; Kravtzova, Olga; Klimkina, Juliana; Kosovtzeva, Arjuna] Sci Ctr Family Hlth & Human Reprod Problems, Dept Pediat, Timiryazeva St 16, Irkutsk 664003, Russia.
C3 Irkutsk Science Centre of the Russian Academy of Sciences; Scientific
   Centre for Family Health & Human Reproduction Problems
RP Pogodina, A (corresponding author), Sci Ctr Family Hlth & Human Reprod Problems, Dept Pediat, Timiryazeva St 16, Irkutsk 664003, Russia.
EM pogodina_av@inbox.ru
RI Pogodina, Anna/O-2744-2019; Kosovtseva, Arjuna/ABG-1673-2020; Rychkova,
   Lyubov/AAH-9714-2020; Pogodina, Anna/O-6248-2015
OI Pogodina, Anna/0000-0001-8533-3119; Rychkova, Lyubov/0000-0002-0117-2563
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NR 51
TC 24
Z9 27
U1 0
U2 5
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 2153-2168
EI 2153-2176
J9 CHILD OBES
JI Child Obes.
PD DEC
PY 2017
VL 13
IS 6
BP 499
EP 506
DI 10.1089/chi.2016.0330
PG 8
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Pediatrics
GA FP5AS
UT WOS:000417630200008
PM 28719224
DA 2025-06-11
ER

PT J
AU Chen, CH
   Wu, MS
   Yang, YW
   Liu, YT
   Chiu, YF
   Hsu, CC
   Chuang, SC
   Chung, TC
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   Huang, WH
   Huang, WL
   Juan, CC
   Lien, LM
   Hsiung, CA
   Wu, IC
AF Chen, Chang-Hua
   Wu, Ming-Shiang
   Yang, Yu-Wen
   Liu, Yen-Tze
   Chiu, Yen-Feng
   Hsu, Chih-Cheng
   Chuang, Shu-Chun
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   Tsai, Tsung-Lung
   Huang, Wen-Hao
   Huang, Wei-Lin
   Juan, Chung-Chou
   Lien, Li-Ming
   Hsiung, Chao A.
   Wu, I-Chien
TI Longitudinal changes in physical and mental health of older adults with
   chronic hepatitis B infection: Trajectories and predictors
SO PREVENTIVE MEDICINE REPORTS
LA English
DT Article
DE Health-related quality of life; Aging; Geriatric assessment; Group-based
   trajectory modeling; Healthy Aging Longitudinal Study in Taiwan (HALST)
ID QUALITY-OF-LIFE; METABOLIC SYNDROME; MORTALITY; COHORT; RISK;
   PREVALENCE; DEPRESSION; DISEASE; OBESITY
AB Despite the increasing health burden of chronic hepatitis B (CHB) in aging populations, little is known about the course of health-related quality of life (HRQoL) changes. We aimed to assess individual-level longitudinal HRQoL changes in elderly patients with CHB and to examine their correlates. A prospective 5.1 years-cohort study was conducted in community-dwelling adults aged 55 years with hepatitis B surface antigen-positive. Participants underwent serial measurement of HRQoL using the short-form (12) health survey version 2. Of 503 participants, 82.7% remained in good physical health throughout the study period, whereas 9.1% had declining physical health and 8.2% were in poor physical health. We likewise identified three trajectories of mental health changes ("good mental health" [86.9%], "declining mental health" [6.8%], and "poor mental health" [6.4%]). Three baseline characteristics were independently associated with a lower likelihood of remaining physically or mentally healthy: sarcopenic obesity (odds ratio [OR] with 95% confidence interval [95% CI] of 7.5 [2.8-20.5] for poor physical health, 3.1 [1.1-8.4] for declining physical health, 4.3 [1.4-13.0] for poor mental health), a higher number of metabolic abnormalities (OR [95% CI] of 3.6 [1.6-8.0] for poor physical health) and depressed mood (OR [95% CI] of 21.7 [5.8-81.0] for poor physical health, 5.3 [1.4-19.9] for declining physical health, 83.1 [19.7-350.2] for poor mental health, 13.6 [2.9-64.8] for declining mental health). In conclusion, in a cohort of elderly patients with CHB, we demonstrated the heterogeneity and nonlinearity of HRQoL changes and their associations with variations in specific extrahepatic organs/systems.
C1 [Chen, Chang-Hua] Changhua Christian Hosp, Dept Internal Med, Changhua, Taiwan.
   [Chen, Chang-Hua; Yang, Yu-Wen; Liu, Yen-Tze] Changhua Christian Hosp, Ctr Aging & Hlth, Changhua, Taiwan.
   [Wu, Ming-Shiang; Chiu, Yen-Feng; Hsu, Chih-Cheng; Chuang, Shu-Chun; Hsiung, Chao A.; Wu, I-Chien] Natl Hlth Res Inst, Inst Populat Hlth Sci, 35 Keyan Rd, Zhunan 35053, Miaoli County, Taiwan.
   [Yang, Yu-Wen; Liu, Yen-Tze] Changhua Christian Hosp, Dept Family Med, Changhua, Taiwan.
   [Chung, Tieh-Chi] Hope Doctors Hosp, Miaoli, Miaoli Cty, Taiwan.
   [Tsai, Tsung-Lung] Puzi Hosp, Minist Hlth & Welf, Puzi, Chiayi, Taiwan.
   [Huang, Wen-Hao] Yeezen Gen Hosp, Taoyuan, Taiwan.
   [Huang, Wei-Lin] Mennonite Christian Hosp, Hualien, Taiwan.
   [Juan, Chung-Chou] Yuans Gen Hosp, Kaohsiung, Taiwan.
   [Lien, Li-Ming] Shin Kong Wu Ho Su Mem Hosp, Dept Neurol, Taipei, Taiwan.
   [Lien, Li-Ming] Taipei Med Univ, Coll Med, Sch Med, Dept Neurol, Taipei, Taiwan.
   [Wu, I-Chien] China Med Univ, Grad Inst Biomed Sci, Taichung, Taiwan.
C3 Changhua Christian Hospital; Changhua Christian Hospital; National
   Health Research Institutes - Taiwan; Changhua Christian Hospital; Shin
   Kong Wu Ho Su Memorial Hospital; Taipei Medical University; China
   Medical University Taiwan
RP Wu, IC (corresponding author), Natl Hlth Res Inst, Inst Populat Hlth Sci, 35 Keyan Rd, Zhunan 35053, Miaoli County, Taiwan.
EM icwu@nhri.edu.tw
RI huang, wenhao/ADI-2707-2022; Liu, Yen Tze/AAT-8989-2021; Yang,
   Yuwen/AAA-6183-2019; Huang, Weilin/AFN-0574-2022; Lin,
   Chih-Cheng/IQT-4912-2023; Hsu, Chih-Cheng/E-3849-2010; LIN,
   HUI-CHEN/AAA-8973-2021; WU, I-CHIEN/C-1515-2011
OI Chuang, Shu-Chun/0000-0002-1190-5687; chen,
   changhua/0000-0003-4564-8727; Liu, Yen-Tze/0000-0002-5922-2295; WU,
   I-CHIEN/0000-0002-6916-8165
FU National Health Research Institutes in Taiwan [BS-097-SP-04,
   PH-098-SP-02, PH-099-SP-01, PH-100-SP-01, PH-101-SP-01, PH-102-SP-01,
   PH-103-SP-01, PH-104-SP-01, PH-105-SP-01, PH-106-SP-01, PH-107-SP-01,
   PH-107-PP-22, PH-108-SP-01, PH-108-PP-22]
FX This work was supported by the National Health Research Institutes in
   Taiwan. (Project nos. BS-097-SP-04, PH-098-SP-02, PH-099-SP-01,
   PH-100-SP-01, PH-101-SP-01, PH-102-SP-01, PH-103-SP-01, PH-104-SP-01,
   PH-105-SP-01, PH-106-SP-01, PH-107-SP-01, PH-107-PP-22, PH-108-SP-01,
   PH-108-PP-22). The sponsors had no roles in the design, methods, subject
   recruitment, data collections, analysis, or preparation of the paper.
CR [Anonymous], 1993, Health status and health policy: quality of life in health care evaluation and resource allocation
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NR 38
TC 4
Z9 4
U1 1
U2 9
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
EI 2211-3355
J9 PREV MED REP
JI Prev. Med. Rep.
PD SEP
PY 2021
VL 23
AR 101432
DI 10.1016/j.pmedr.2021.101432
EA JUN 2021
PG 8
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA UA0MU
UT WOS:000684860600022
PM 34150482
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Kargar, B
   Zamanian, Z
   Hosseinabadi, MB
   Gharibi, V
   Moradi, MS
   Cousins, R
AF Kargar, Behnam
   Zamanian, Zahra
   Hosseinabadi, Majid Bagheri
   Gharibi, Vahid
   Moradi, Mohammad Sanyar
   Cousins, Rosanna
TI Understanding the role of oxidative stress in the incidence of metabolic
   syndrome and obstructive sleep apnea
SO BMC ENDOCRINE DISORDERS
LA English
DT Article
DE MetS; Obesity; OSA; Oxidative stress; Work environment
ID STOP-BANG QUESTIONNAIRE; HEAT-STRESS; ADIPONECTIN; BIOMARKERS; EXERCISE;
   OBESITY; RISK
AB Background Understanding the causes and risk factors of metabolic syndrome is important for promoting population health. Oxidative stress has been associated with metabolic syndrome, and also obstructive sleep apnea. These are two diseases which have common prognostic characteristics for heart disease. The aim of this study was to examine the role of oxidative stress in the concurrent presence of metabolic syndrome and obstructive sleep apnea in a working population. Methods Participants were 163 artisan bakers in Shahroud, Iran, routinely exposed to significant heat stress and other oxidative stress indicators on a daily basis as part of their work. Using a cross-sectional design, data relevant to determining metabolic syndrome status according to International Diabetes Federation criteria, and the presence of obstructive sleep apnea according to the STOP-Bang score, was collected. Analyses included hierarchical binary logistic regression to yield predictors of the two diseases. Results Hierarchical binary logistic regression showed that oxidative stress - alongside obesity, no regular exercise, and smoking - was an independent predictor of metabolic syndrome, but not obstructive sleep apnea. Participants who were obese were 28 times more likely to have metabolic syndrome (OR 28.59, 95% CI 4.91-63.02) and 44 times more likely to have obstructive sleep apnea (OR 44.48, 95% CI 4.91-403.28). Participants meeting metabolic syndrome criteria had significantly higher levels of malondialdehyde (p < 0.05) than those who did not. No difference in oxidative stress index levels were found according to obstructive sleep apnea status. Conclusions Our findings suggest that oxidative stress contributes to the onset of metabolic syndrome, and that obstructive sleep apnea is involved in oxidative stress. Whilst obesity, exercise, and smoking remain important targets for reducing the incidence of metabolic syndrome and obstructive sleep apnea, policies to control risks of prolonged exposure to oxidative stress are also relevant in occupations where such environmental conditions exist.
C1 [Kargar, Behnam] Shiraz Univ Med Sci, Med Sch, Dept Pharmacol, Shiraz, Iran.
   [Zamanian, Zahra; Gharibi, Vahid; Moradi, Mohammad Sanyar] Shiraz Univ Med Sci, Sch Hlth, Dept Occupat Hlth, Shiraz, Iran.
   [Hosseinabadi, Majid Bagheri; Gharibi, Vahid] Shahroud Univ Med Sci, Sch Publ Hlth, Shahroud, Iran.
   [Cousins, Rosanna] Liverpool Hope Univ, Dept Psychol, Liverpool, Merseyside, England.
C3 Shiraz University of Medical Science; Shiraz University of Medical
   Science; Shahroud University Medical Sciences; University of Liverpool;
   Liverpool Hope University
RP Gharibi, V (corresponding author), Shiraz Univ Med Sci, Sch Hlth, Dept Occupat Hlth, Shiraz, Iran.; Gharibi, V (corresponding author), Shahroud Univ Med Sci, Sch Publ Hlth, Shahroud, Iran.; Cousins, R (corresponding author), Liverpool Hope Univ, Dept Psychol, Liverpool, Merseyside, England.
EM gharibivahid@gmail.com; cousinr@hope.ac.uk
RI Bagheri Hosseinabadi, Majid/ACP-7151-2022; zamanian, Zahra/D-9632-2012;
   Gharibi, Vahid/Q-6954-2018; Cousins, Rosanna/H-6358-2019
OI mordi, mohammad sanyar/0000-0001-8801-0753; gharibi,
   vahid/0000-0002-9974-3060; Bagheri Hosseinabadi,
   Majid/0000-0002-5477-199X; Cousins, Rosanna/0000-0003-4829-5138;
   Zamanian, Zahra/0000-0003-2462-2456
FU Shahroud University of Medical Sciences [9529]
FX The research in this paper was supported by Grant No 9529 from Shahroud
   University of Medical Sciences. This grant did not provide Shahroud
   University with any influence on the design of the study, or the
   drafting of this manuscript. Similarly, there was no correspondence with
   the funding body with respect to data collection, analysis or
   interpretation.
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NR 41
TC 11
Z9 13
U1 0
U2 4
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1472-6823
J9 BMC ENDOCR DISORD
JI BMC Endocr. Disord.
PD APR 21
PY 2021
VL 21
IS 1
AR 77
DI 10.1186/s12902-021-00735-4
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA RS4YT
UT WOS:000643787300001
PM 33882916
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Cattaneo, MM
   Pravatà, E
   Provenzi, M
   Moccetti, M
   Kaelin, A
   Sudano, I
   Biasucci, L
   Gallino, C
   Limoni, C
   Calanchini, C
   Gallino, A
   Crea, F
   Cattaneo, M
AF Cattaneo, Magdalena Maria
   Pravata, Emanuele
   Provenzi, Micol
   Moccetti, Marco
   Kaelin, Alain
   Sudano, Isabella
   Biasucci, Luigi
   Gallino, Camilla
   Limoni, Costanzo
   Calanchini, Carlo
   Gallino, Augusto
   Crea, Filippo
   Cattaneo, Mattia
TI Role of the central autonomic nervous system intrinsic functional
   organisation and psychosocial factors in primary microvascular angina
   and Takotsubo syndrome
SO OPEN HEART
LA English
DT Article
DE autonomic regulation; endothelial function; cardiomyopathy apical;
   microvascular; syndrome X
ID TAKO-TSUBO CARDIOMYOPATHY; CARDIAC SYNDROME-X; QUALITY-OF-LIFE; CLINICAL
   PRESENTATION; HEALTH SURVEY; PRIMARY-CARE; CHEST-PAIN; STRESS; BRAIN;
   DYSFUNCTION
AB Introduction and objective Dysfunctional central autonomic nervous system network (CAN) at rest may result in aberrant autonomic responses to psychosocial stressors. We hypothesised that patients with primary microvascular angina (MVA) or Takotsubo syndrome (TTS) would exhibit a peculiar functional organisation of the CAN, potentially associated with psychological patterns.
   Methods Patients underwent a psychosocial evaluation: a clinical diagnostic interview, Millon Clinical Multiaxial Inventory III, State-Trait Anxiety Inventory form Y and Short Form 36 Health Survey (SF-36). The strength of intrinsic functional connectivity (FC) between various nodes of the CAN was investigated using cerebral resting state functional MRI (RS-fMRI).
   Results We evaluated 50 (46 women) stable patients: 16 patients with MVA, 17 patients with TTS and 17 patients with previous acute myocardial infarction (AMI). Compared with AMI, patients with MVA showed a lower (higher impairment) SF-36 Body-Pain score (p 0.046) and a higher SF-36 Mental-Health score (p 0.039). Patients with TTS showed the strongest FC between two nodes of the CAN (sympathetic midcingulate cortex and parasympathetic primary motor area) (F 6.25, p 0.005) using RS-fMRI.
   Conclusions The study implements an innovative collaborative research among cardiologists, neuroscientists and psychiatrists ('Neuro-psycho-heart Team'). MVA showed a discrepancy between the highest level of self-reported body pain and the best mental health score, which might suggest a mechanism of somatisation. TTS exhibited an increased functional integration between two areas of the CAN involved in interoceptive pain awareness and negative emotional status. We implemented an innovative research collaboration among cardiologists, neuroscientists and psychiatrists. These data are hypothesis generating and suggest potential prospective investigations on pathophysiology and implementation of psychotherapy and stress-reducing techniques as therapeutic strategies.
C1 [Cattaneo, Magdalena Maria; Gallino, Camilla; Gallino, Augusto; Cattaneo, Mattia] Hosp San Giovanni, Cardiovasc Res, Bellinzona, Switzerland.
   [Cattaneo, Magdalena Maria] Hosp San Giovanni, Internal Med, Bellinzona, Switzerland.
   [Pravata, Emanuele; Kaelin, Alain] Neuroctr Southern Switzerland, Neuroradiol, Lugano, Switzerland.
   [Provenzi, Micol] Psychoeduc Ctr, Psychol, Stabio, Switzerland.
   [Moccetti, Marco; Cattaneo, Mattia] Cardioctr Ticino, Cardiol, Lugano, Switzerland.
   [Sudano, Isabella] Univ Heart Ctr, Cardiol, Zurich, Switzerland.
   [Biasucci, Luigi; Crea, Filippo] Univ Cattolica Sacro Cuore, Cardiol, Rome, Italy.
   [Limoni, Costanzo] Univ Appl Sci & Arts Southern Switzerland, Biostat, Lugano, Switzerland.
   [Calanchini, Carlo] Hosp Malcantonese Castelrotto, Psychiat, Castelrotto, Switzerland.
   [Gallino, Augusto] Univ Zurich, Cardiol, Zurich, Switzerland.
C3 Regional Hospital of Bellinzona & Valleys, San Giovanni; Regional
   Hospital of Bellinzona & Valleys, San Giovanni; Catholic University of
   the Sacred Heart; IRCCS Policlinico Gemelli; University of Zurich
RP Cattaneo, MM (corresponding author), Hosp San Giovanni, Cardiovasc Res, Bellinzona, Switzerland.; Cattaneo, MM (corresponding author), Hosp San Giovanni, Internal Med, Bellinzona, Switzerland.
EM cattaneo.magdalena@gmail.com
RI Crea, Filippo/AAC-9754-2022; Kaelin, Alain/GQI-3930-2022; Pravatà,
   Emanuele/AGS-4055-2022
OI Cattaneo, Mattia/0000-0002-9923-9470; Pravata,
   Emanuele/0000-0002-5225-2993; Kaelin-Lang, Alain/0000-0002-5249-073X
FU Swiss Heart Foundation
FX This study was funded by Swiss Heart Foundation.
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NR 47
TC 2
Z9 2
U1 0
U2 4
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2053-3624
J9 OPEN HEART
JI Open Heart
PD AUG
PY 2020
VL 7
IS 2
AR e001315
DI 10.1136/openhrt-2020-001315
PG 10
WC Cardiac & Cardiovascular Systems
WE Emerging Sources Citation Index (ESCI)
SC Cardiovascular System & Cardiology
GA ND3AK
UT WOS:000561776000001
PM 32727853
OA gold, Green Accepted, Green Published
DA 2025-06-11
ER

PT J
AU Saiga, M
   Ikeda, T
   Yoshioka, S
AF Saiga, Michiko
   Ikeda, Tadasu
   Yoshioka, Shin-ichi
TI Physical and Mental Factors Associated with Obesity in Individuals with
   Mental Disorders Attending Psychiatric Day-Care Facilities
SO YONAGO ACTA MEDICA
LA English
DT Article
DE Breslow's health index; metabolic syndrome; mental disorder; obesity;
   psychiatric day-care facility
ID DEPRESSIVE SYMPTOMS; METABOLIC SYNDROME; WEIGHT-GAIN; LIFE-STYLE;
   SCHIZOPHRENIA; PROGRAM; MANAGEMENT; JAPANESE
AB Background Individuals with mental disorders have increased rates of obesity and metabolic syndrome. Here we evaluated factors influencing obesity in individuals with mental disorders who were attending psychiatric day-care facilities on an outpatient basis.
   Methods The subjects (n = 108) were outpatients attending hospital-based rehabilitation programs. We assessed body fat, weight, height, waist circumference, body mass index (BMI), blood pressure, Geriatric Depression Scale-15 (GDS) scores, frequency of day-care visits, satisfaction with body shape, physical comorbidity and lifestyle habits. Lifestyle habits were evaluated using Breslow's health index based on health-related choices.
   Results The subjects were divided into 2 groups: obese group (BMI >= 25 kg/m(2)) and non-obese group (BMI < 25 kg/m(2)). The physical parameters and attributes of both groups were compared, and factors related to BMI were statistically analyzed. The prevalence of obesity was 47.2% in all patients, 42.4% in males and 54.8% in females. Weight, waist circumference, body fat and systolic and diastolic blood pressure were significantly higher in the obese group than in the nonobese group. Body fat, waist circumference, systolic blood pressure and diastolic blood pressure exhibited significant positive correlations with BMI, whereas the frequency of day-care visits, satisfaction with body shape, GDS score and Breslow's health index exhibited significant negative correlations with BMI.
   Conclusion The present results showed that the prevalence of obesity was high in outpatients with mental disorders. Improvement in lifestyle choices is necessary to prevent obesity and the onset of metabolic syndrome in such patients.
C1 [Saiga, Michiko; Yoshioka, Shin-ichi] Tottori Univ, Fac Med, Sch Hlth Sci, Dept Nursing Care Environm & Mental Hlth, Yonago, Tottori 6838503, Japan.
   [Ikeda, Tadasu] Sumiyoshi Naika Ganka Clin, Yonago, Tottori 6830846, Japan.
C3 Tottori University
RP Saiga, M (corresponding author), Tottori Univ, Fac Med, Sch Hlth Sci, Dept Nursing Care Environm & Mental Hlth, Yonago, Tottori 6838503, Japan.
EM michi15@med.tottori-u.ac.jp
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NR 35
TC 2
Z9 2
U1 0
U2 4
PU TOTTORI UNIV, FACULTY MEDICINE
PI YONAGO
PA 86 NISHI-CHO, YONAGO, TOTTORI-KEN 683-8503, JAPAN
SN 0513-5710
J9 YONAGO ACTA MED
JI Yonago Acta Med.
PD MAR
PY 2013
VL 56
IS 1
BP 1
EP 6
PG 6
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 165GT
UT WOS:000320472200001
PM 24031145
DA 2025-06-11
ER

PT J
AU Lubas, MM
   Mandrell, BN
   Ness, KK
   Srivastava, DK
   Ehrhardt, MJ
   Wang, ZM
   Hudson, MM
   Robison, LL
   Krull, KR
   Brinkman, TM
AF Lubas, Margaret M.
   Mandrell, Belinda N.
   Ness, Kirsten K.
   Srivastava, Deo Kumar
   Ehrhardt, Matthew J.
   Wang, Zhaoming
   Hudson, Melissa M.
   Robison, Leslie L.
   Krull, Kevin R.
   Brinkman, Tara M.
TI Short sleep duration and physical and psychological health outcomes
   among adult survivors of childhood cancer
SO PEDIATRIC BLOOD & CANCER
LA English
DT Article
DE anxiety; chronic health conditions; depression; short sleep duration
ID LONG-TERM SURVIVORS; METABOLIC SYNDROME; LIFE-STYLE; DISEASE;
   METAANALYSIS; RISK; INTERVENTIONS; DISTURBANCE; DEPRESSION; MORTALITY
AB Background To examine associations between phenotypes of short sleep duration and clinically assessed health conditions in long-term survivors of childhood cancer.
   Methods Survivors recruited from the St. Jude Lifetime Cohort (n = 911; 52% female; mean age 34 years; 26 years postdiagnosis) completed behavioral health surveys and underwent comprehensive physical examinations. Sleep was assessed with the Pittsburgh Sleep Quality Index. Short sleep was defined as <= 6 h per night with phenotypes of short sleep including poor sleep efficiency (<85%), prolonged sleep onset latency (SOL; >= 30 min), and wake after sleep onset (>= 3 times per week). Covariates included childhood cancer treatment exposures, demographics, body mass index, and physical inactivity. Separate modified Poisson regression models were computed for each health category to estimate relative risks (RR) and 95% confidence intervals (CI). Multinomial logistic regression models examined associations between sleep and an aggregated burden of chronic health conditions.
   Results Short sleep duration was reported among 44% (95% CI 41%-47%) of survivors. In multivariable models, short sleep duration alone was associated with pulmonary (RR = 1.35, 95% CI 1.08-1.69), endocrine (RR = 1.22, 95% CI 1.06-1.39) and gastrointestinal/hepatic conditions (RR = 1.46, 95% CI 1.18-1.79), and anxiety (RR 3.24, 95% CI 1.64-6.41) and depression (RR = 2.33, 95% CI 1.27-4.27). Short sleep with prolonged SOL was associated with a high/severe burden of health conditions (OR = 2.35, 95% CI 1.12-4.94).
   Conclusions Short sleep duration was associated with multiple clinically ascertained adverse health conditions. Although the temporality of these associations cannot be determined in this cross-sectional study, sleep is modifiable and improving sleep may improve long-term health in survivors.
C1 [Lubas, Margaret M.; Ness, Kirsten K.; Ehrhardt, Matthew J.; Wang, Zhaoming; Hudson, Melissa M.; Robison, Leslie L.; Krull, Kevin R.; Brinkman, Tara M.] St Jude Childrens Res Hosp, Dept Epidemiol & Canc Control, 262 Danny Thomas Pl,MS 735, Memphis, TN 38105 USA.
   [Mandrell, Belinda N.] St Jude Childrens Res Hosp, Dept Pediat Med, 332 N Lauderdale St, Memphis, TN 38105 USA.
   [Srivastava, Deo Kumar] St Jude Childrens Res Hosp, Dept Biostat, 332 N Lauderdale St, Memphis, TN 38105 USA.
   [Ehrhardt, Matthew J.; Hudson, Melissa M.] St Jude Childrens Res Hosp, Dept Oncol, 332 N Lauderdale St, Memphis, TN 38105 USA.
   [Krull, Kevin R.; Brinkman, Tara M.] St Jude Childrens Res Hosp, Dept Psychol, 332 N Lauderdale St, Memphis, TN 38105 USA.
C3 St Jude Children's Research Hospital; St Jude Children's Research
   Hospital; St Jude Children's Research Hospital; St Jude Children's
   Research Hospital; St Jude Children's Research Hospital
RP Brinkman, TM (corresponding author), St Jude Childrens Res Hosp, Dept Epidemiol & Canc Control, 262 Danny Thomas Pl,MS 735, Memphis, TN 38105 USA.
EM tara.brinkman@stjude.org
RI Robison, Leslie/N-8122-2018; Ehrhardt, Matt/N-3105-2018; Mandrell,
   Belinda/N-8066-2018; Brinkman, Tara/N-8171-2018; Krull,
   Kevin/N-3882-2018; Wang, Zhaoming/R-5527-2018; Ness, Kirsten/N-2550-2018
OI Brinkman, Tara/0000-0002-4250-6160; Lubas, Margaret/0000-0001-5248-8421;
   Krull, Kevin/0000-0002-0476-7001; Wang, Zhaoming/0000-0001-7556-3869;
   Ness, Kirsten/0000-0002-2084-1507
FU National Cancer Institute at the National Institutes of Health
   [CA195547, CA239689]; National Cancer Institute Training in Pediatric
   Cancer Care Survivorship award [5T32CA225590]; Cancer Center Support
   (CORE) grant [CA21765]; American Lebanese Syrian Associated Charities
   (ALSAC); National Cancer Institute [U01CA195547] Funding Source: NIH
   RePORTER
FX This work was supported by the National Cancer Institute at the National
   Institutes of Health (CA195547, M. Hudson and L. Robison, Principal
   Investigators; CA239689, T. Brinkman and K. Krull, Principal
   Investigators) and by the National Cancer Institute Training in
   Pediatric Cancer Care Survivorship award (5T32CA225590, K. Krull,
   Principal Investigator). The content is solely the responsibility of the
   authors and does not necessarily represent the official views of the
   National Institutes of Health. Support to St. Jude Children's Research
   Hospital was also provided by the Cancer Center Support (CORE) grant
   (CA21765, C. Roberts, Principal Investigator) and the American Lebanese
   Syrian Associated Charities (ALSAC).
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NR 50
TC 5
Z9 5
U1 1
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1545-5009
EI 1545-5017
J9 PEDIATR BLOOD CANCER
JI Pediatr. Blood Cancer
PD JUL
PY 2021
VL 68
IS 7
AR e28988
DI 10.1002/pbc.28988
EA APR 2021
PG 10
WC Oncology; Hematology; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Oncology; Hematology; Pediatrics
GA SJ9DL
UT WOS:000637056700001
PM 33822460
OA Green Accepted, Green Submitted
DA 2025-06-11
ER

PT J
AU Demirci, H
   Cinar, Y
   Bilgel, N
AF Demirci, Hakan
   Cinar, Yildirim
   Bilgel, Nazan
TI Metabolic Syndrome and tepressive Symptoms in a Primary Health Care
   Setting in Turkey
SO KLINIK PSIKOFARMAKOLOJI BULTENI-BULLETIN OF CLINICAL PSYCHOPHARMACOLOGY
LA English
DT Article
DE Metabolic syndrome; adult population; depressive symptoms; family
   practice; Turkey
ID DEPRESSIVE SYMPTOMS; CHOLESTEROL LEVELS; YOUNG-ADULTS; OLDER MEN;
   ASSOCIATION; RISK; ANXIETY; COOCCURRENCE; PREVALENCE; OBESITY
AB Background: The possible association between depressive symptoms and metabolic syndrome (MetS) has recently become an important topic of discussion. There is some limited and inconsistent evidence in the literature concerning whether or not depression and metabolic syndrome are associated. The aim of this study was to examine the association between depressive symptoms and metabolic syndrome.
   Methods: This is a cross-sectional community-based study. The setting is a family practice unit in an urban area which serves about 3,600 people. The participants were 250 individuals aged 18 and over, selected randomly from all enrolled patients in this family practice unit. National Cholesterol Education Program (NCEP- ATP-III) criteria were used for the classification of metabolic myndrome (MetS). The Beck Depression Inventory was filled out by the participants for the evaluation of depressive symptoms.
   Results: The prevalence of MetS was similar for men (48.8%) and women (48.1%) and increased with age in both sexes. Participants with only primary education were found to be 2.2 times more at risk of developing MetS than participants with a higher education. The prevalence of depressive symptoms was higher among women (31.0%) than men (9.9%). Statistical analyses revealed no statistically significant association between MetS and depressive symptoms.
   Conclusion: The prevalence of MetS was found to be high in both sexes. Women had a 3.8 times higher risk of developing depressive symptoms than men. We found no association of depressive symptoms with MetS or with any of the MetS criteria.
C1 [Cinar, Yildirim] Trakya Univ, Fac Med, Dept Internal Med, Edirne, Turkey.
   [Bilgel, Nazan] Uludag Univ, Dept Family Med, Fac Med, Bursa, Turkey.
   [Demirci, Hakan] Family Practice Unit, Bursa, Turkey.
C3 Trakya University; Uludag University
RP Demirci, H (corresponding author), Nilufer 9,U Fethiye,Bulvar Aile Sagligi Merkezi,F, TR-16140 Nilufer, Bursa, Turkey.
EM drhakandemirci@hotmail.com
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NR 46
TC 17
Z9 20
U1 0
U2 5
PU KURE ILETISIM GRUBU A S
PI ISTANBUL
PA SIRACEVIZLER CAD 43/3 SISLI, ISTANBUL, 34381, TURKEY
SN 1017-7833
J9 KLIN PSIKOFARMAKOL B
JI Klin. Psikofarmakol. Bul.
PD MAR
PY 2011
VL 21
IS 1
BP 49
EP 57
PG 9
WC Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Psychiatry
GA 760ZN
UT WOS:000290364100008
DA 2025-06-11
ER

PT J
AU Zhang, P
   Tian, B
AF Zhang, Pei
   Tian, Bo
TI Metabolic Syndrome: An Important Risk Factor for Parkinson's Disease
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Review
ID HIGH-FAT DIET; HYDROGEN-RICH WATER; OXIDATIVE STRESS; VITAMIN-D;
   MOLECULAR-HYDROGEN; CELL-DEATH; RAT MODEL; CEREBROSPINAL-FLUID;
   NITROSATIVE STRESS; FUTURE RISK
AB Metabolic syndrome is becoming commoner due to a rise in obesity rates among adults. Generally speaking, a person with metabolic syndrome is twice as likely to develop cardiovascular disease and five times as likely to develop diabetes as someone without metabolic syndrome. Increasing oxidative stress inmetabolic syndrome and Parkinson's disease is mentioned in the comprehensive articles; however, the system review about clear relation between metabolic syndrome and Parkinson's disease is deficient. In this review, we will focus on the analysis that the metabolic syndrome may be a risk factor for Parkinson's disease and the preventions that reduce the incident of Parkinson's disease by regulating the oxidative stress.
C1 [Zhang, Pei; Tian, Bo] Huazhong Univ Sci & Technol, Dept Neurobiol, Tongji Med Sch, Wuhan 430030, Hubei, Peoples R China.
   [Zhang, Pei; Tian, Bo] Minist Educ, Key Lab Neurol Dis, Wuhan 430030, Hubei, Peoples R China.
C3 Huazhong University of Science & Technology; Ministry of Education -
   China
RP Tian, B (corresponding author), Huazhong Univ Sci & Technol, Dept Neurobiol, Tongji Med Sch, 13 Hangkong Rd, Wuhan 430030, Hubei, Peoples R China.
EM tianbo@mails.tjmu.edu.cn
RI Zhang, Pei/AAC-7638-2019; Tian, Bo/G-2354-2011
OI Zhang, Pei/0000-0003-0608-5677; Tian, Bo/0000-0002-8318-3046
FU NSFC [31071208, 31371384]
FX This study was supported by NSFC (nos. 31071208 and 31371384).
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NR 102
TC 67
Z9 69
U1 0
U2 28
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PY 2014
VL 2014
AR 729194
DI 10.1155/2014/729194
PG 7
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA AH7BM
UT WOS:000336287400001
PM 24955210
OA Green Published, hybrid, Green Submitted
DA 2025-06-11
ER

PT J
AU Grant, MC
   Baker, JS
AF Grant, Marie Clare
   Baker, Julien S.
TI An overview of the effect of probiotics and exercise on mood and
   associated health conditions
SO CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
LA English
DT Review
DE Probiotics; gut microbiota; chronic disease; exercise; obesity
ID IRRITABLE-BOWEL-SYNDROME; CHRONIC-FATIGUE-SYNDROME; ANXIETY-LIKE
   BEHAVIOR; GUT MICROBIOTA; PHYSICAL-ACTIVITY; COGNITIVE REACTIVITY;
   METABOLIC SYNDROME; BRAIN; MECHANISMS; DEPRESSION
AB The present paper provides a review of the current knowledge relating to the health benefits of probiotics, specially focused on the effects they may have together with physical exercise on mood disorders and related chronic medical conditions. With both these conditions being a substantial contributor to the global disease burden, any alternative therapy must be considered. Probiotics influence the gut microbiota through a complex network of events which can influence mechanisms leading to development of mood disorders such as depression and anxiety. Similarly, through a complex interaction between psychological and neurobiological mechanisms, exercise has been found to play a key role in mood enhancement.
C1 [Grant, Marie Clare] Abertay Univ, Sch Social & Hlth Sci, Bell St, Dundee DD1 1HG, Scotland.
   [Baker, Julien S.] Univ West Scotland, Hamilton, England.
C3 University of Abertay Dundee
RP Grant, MC (corresponding author), Abertay Univ, Sch Social & Hlth Sci, Bell St, Dundee DD1 1HG, Scotland.
EM marieclare.grant@abertay.ac.uk
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NR 64
TC 18
Z9 18
U1 2
U2 59
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1040-8398
EI 1549-7852
J9 CRIT REV FOOD SCI
JI Crit. Rev. Food Sci. Nutr.
PY 2017
VL 57
IS 18
BP 3887
EP 3893
DI 10.1080/10408398.2016.1189872
PG 7
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA FT8VC
UT WOS:000423430300008
PM 27246320
OA Green Accepted, Green Submitted
DA 2025-06-11
ER

PT J
AU Shea, S
   Lionis, C
   Kite, C
   Atkinson, L
   Lagojda, L
   Chaggar, SS
   Kyrou, I
   Randeva, HS
AF Shea, Sue
   Lionis, Christos
   Kite, Chris
   Atkinson, Lou
   Lagojda, Lukasz
   Chaggar, Surinderjeet S.
   Kyrou, Ioannis
   Randeva, Harpal S.
TI Challenges in the Management of Non-Alcoholic Fatty Liver Disease
   (NAFLD): Towards a Compassionate Approach
SO LIVERS
LA English
DT Review
DE non-alcoholic fatty liver disease; NAFLD; obesity; stigma; mental
   stress; loneliness; compassion; motivational interviewing; social
   prescribing; empathy
ID PRIMARY-CARE; RISK
AB Representing a growing 'silent epidemic', non-alcoholic fatty liver disease (NAFLD) affects around 25-30% of the general population. Alarmingly, NAFLD increases the risk of cardiovascular disease, both independently and through its strong associations with obesity, type 2 diabetes, and metabolic syndrome, whilst posing a substantial burden from an economic and health-related quality of life perspective. Moreover, growing evidence links NAFLD to common mental health disorders including depression, anxiety, and stress. In this context, recent clinical and research attention further focuses on potential additional problems faced by patients with NAFLD, such as perceived stigma, lack of awareness regarding the condition, and possible feelings of loneliness and isolation that might emerge from unmet support needs. To date, despite a wealth of literature on NAFLD, management of the condition remains challenging and not straightforward, with most cases in primary care being treated with lifestyle modification on top of any other comorbidity treatment. However, for many patients with NAFLD, weight loss is hard to accomplish and/or sustain (e.g., patients may lack the skills, confidence, and motivation required to adhere to dietary changes, and/or may have problems limiting opportunities for increased physical activity). Therefore, tailored interventions which are manageable from the perspective of the individual patient with NAFLD could glean greater results. Accordingly, although there is a lack of research exploring the potential benefits of person-centered and compassion-based approaches to the management of NAFLD, in the present review, we draw on evidence from methods utilized in the treatment of other chronic conditions in postulating the view that such approaches might prove beneficial in the future management of NAFLD.
C1 [Shea, Sue; Atkinson, Lou; Kyrou, Ioannis; Randeva, Harpal S.] Univ Warwick, Warwick Med Sch, Coventry CV4 7AL, England.
   [Shea, Sue; Kite, Chris; Atkinson, Lou; Kyrou, Ioannis; Randeva, Harpal S.] Univ Hosp Coventry & Warwickshire NHS Trust, Warwickshire Inst Study Diabet Endocrinol & Metab, Coventry CV2 2DX, England.
   [Lionis, Christos] Univ Crete, Sch Med, Lab Hlth & Sci, Iraklion 71003, Greece.
   [Lionis, Christos] Univ Linkoping, Dept Hlth Med & Caring Sci, SE-58183 Linkoping, Sweden.
   [Lionis, Christos] Frederick Univ, Dept Nursing, CY-1036 Nicosia, Cyprus.
   [Kite, Chris] Univ Wolverhampton, Fac Educ, Sch Hlth & Soc, Wolverhampton WV1 1LY, England.
   [Kite, Chris; Kyrou, Ioannis] Coventry Univ, Res Inst Hlth & Wellbeing, Ctr Sport Exercise & Life Sci, Coventry CV1 5FB, England.
   [Kite, Chris] Univ Chester, Chester Med Sch, Shrewsbury SY3 8HQ, England.
   [Atkinson, Lou] EXI, Peoples Mission Hall,20-30 Whitechapel Rd, London E1 1EW, England.
   [Lagojda, Lukasz] Univ Hosp Coventry & Warwickshire NHS Trust, Clin Evidence Based Informat Serv CEBIS, Coventry CV2 2DX, England.
   [Chaggar, Surinderjeet S.] Forum Hlth Ctr, Sowe Valley Primary Care Network, Coventry CV2 5EP, England.
   [Kyrou, Ioannis] Aston Univ, Coll Hlth & Life Sci, Aston Med Sch, Birmingham B4 7ET, England.
   [Kyrou, Ioannis] Agr Univ Athens, Sch Food & Nutr Sci, Dept Food Sci & Human Nutr, Lab Dietet & Qual Life, Athens 11855, Greece.
C3 University of Warwick; University of Warwick; University of Crete;
   Linkoping University; University of Wolverhampton; Coventry University;
   University of Warwick; Aston University; Agricultural University of
   Athens
RP Kyrou, I; Randeva, HS (corresponding author), Univ Warwick, Warwick Med Sch, Coventry CV4 7AL, England.; Kyrou, I; Randeva, HS (corresponding author), Univ Hosp Coventry & Warwickshire NHS Trust, Warwickshire Inst Study Diabet Endocrinol & Metab, Coventry CV2 2DX, England.; Kyrou, I (corresponding author), Coventry Univ, Res Inst Hlth & Wellbeing, Ctr Sport Exercise & Life Sci, Coventry CV1 5FB, England.; Kyrou, I (corresponding author), Aston Univ, Coll Hlth & Life Sci, Aston Med Sch, Birmingham B4 7ET, England.; Kyrou, I (corresponding author), Agr Univ Athens, Sch Food & Nutr Sci, Dept Food Sci & Human Nutr, Lab Dietet & Qual Life, Athens 11855, Greece.
EM sue.shea@warwick.ac.uk; lionis@uoc.gr; c.kite2@wlv.ac.uk;
   louatkinsonphd@gmail.com; lukasz.lagojda@uhcw.nhs.uk;
   surinder.chaggar@nhs.net; kyrouj@gmail.com; harpal.randeva@uhcw.nhs.uk
RI Lionis, Christos/MBV-1499-2025; Lagojda, Lukasz/HCH-7750-2022
OI Lionis, Christos/0000-0002-9324-2839; Shea, Sue/0000-0003-0745-1085;
   Lagojda, Lukasz/0000-0001-9793-3672; Kite, Chris/0000-0003-1342-274X
FX S.S., I.K. and H.S.R. would like to thank the University Hospitals
   Coventry and Warwickshire (UHCW) NHS Trust and the General Charities of
   Coventry for their ongoing support.
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NR 66
TC 2
Z9 2
U1 1
U2 3
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2673-4389
J9 LIVERS-BASEL
JI Livers
PD SEP
PY 2023
VL 3
IS 3
BP 434
EP 447
DI 10.3390/livers3030031
PG 14
WC Gastroenterology & Hepatology
WE Emerging Sources Citation Index (ESCI)
SC Gastroenterology & Hepatology
GA WI4S2
UT WOS:001254233300001
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Tenk, J
   Mátrai, P
   Hegyi, P
   Rostás, I
   Garami, A
   Szabó, I
   Hartmann, P
   Pétervári, E
   Czopf, L
   Hussain, A
   Simon, M
   Szujó, S
   Balaskó, M
AF Tenk, Judit
   Matrai, Peter
   Hegyi, Peter
   Rostas, Ildiko
   Garami, Andras
   Szabo, Imre
   Hartmann, Petra
   Petervari, Erika
   Czopf, Laszlo
   Hussain, Alizadeh
   Simon, Maria
   Szujo, Szabina
   Balasko, Marta
TI Perceived stress correlates with visceral obesity and lipid parameters
   of the metabolic syndrome: A systematic review and meta-analysis
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Review
DE Perceived stress; Metabolic syndrome; Dyslipidemia; Visceral obesity
ID CARDIOVASCULAR RISK-FACTORS; JOB STRAIN; PSYCHOSOCIAL STRESS; WORK
   STRESS; DIABETES-MELLITUS; SEX-DIFFERENCES; BLOOD-PRESSURE;
   UNITED-STATES; WEIGHT-LOSS; CORTISOL
AB Background: Perceived stress has been proposed as a risk factor of metabolic syndrome. However, correlations between perceived stress and parameters of the metabolic syndrome have not been properly analyzed despite extensive research data on the topic. Our current meta-analysis aimed to examine the mutual association between perceived stress of patients and parameters of metabolic syndrome.
   Methods: This systematic review has been registered on the PROSPERO database (registration number CRD42017055293). Eligible studies divided participants based on their stress level or on the presence of metabolic syndrome. They reported at least one parameter of the metabolic syndrome or the stress level of the participants measured with some stress scale. Data from 17 articles met the eligibility criteria and were included. Random effects model with the DerSimonian and Laird weighting methods was applied. I-squared indicator and Q test were performed to assess heterogeneity.
   Results: Although the majority of individual studies failed to demonstrate correlations between stress and their analyzed parameters of metabolic syndrome, our meta-analysis showed a significant association between stress and BMI [average effect size (ES) with 95% confidence interval (95%CI), ES = 0.65, 95%CI 0.16, 1.14), waist circumference (ES = 1.84 cm, 95%CI 0.79, 2.89) and serum triglyceride level (ES = 7.52 mg/dl, 95%CI 0.07, 14.96). Additional analysis confirmed effects of stress on serum HDL (ES = -1.699 mg/dl, 95%CI -2.966, -0.432) and diastolic blood pressure (ES = 1.04 mmHg, 95%CI 0.18, 1.89). No correlations were found for fasting glucose or systolic blood pressure. No association between metabolic syndrome and stress level of patients was detected either.
   Conclusion: The potentially key role of visceral obesity in the association between perceived stress and dyslipidemia or diastolic blood pressure are discussed together with potential moderators (e.g. gender-differences, variations in stress assessment and metabolic syndrome criteria) that may explain the inconsistent, contradictory results of the individual studies.
C1 [Tenk, Judit; Matrai, Peter; Hegyi, Peter; Rostas, Ildiko; Garami, Andras; Petervari, Erika; Balasko, Marta] Univ Pecs, Med Sch, Inst Translat Med, 1 Szigeti Str, H-7624 Pecs, Hungary.
   [Matrai, Peter] Univ Pecs, Med Sch, Inst Bioanal, Pecs, Hungary.
   [Hegyi, Peter] Univ Pecs, Dept Translat Med, Pecs, Hungary.
   [Hegyi, Peter] Univ Szeged, Momentum Gastroenterol Multidisciplinary Res Grp, Hungarian Acad Sci, Szeged, Hungary.
   [Szabo, Imre] Univ Pecs, Dept Internal Med 1, Dept Gastroenterol, Pecs, Hungary.
   [Hartmann, Petra] Univ Szeged, Inst Surg Res, Szeged, Hungary.
   [Czopf, Laszlo] Univ Pecs, Dept Med 1, Dept Cardiol, Pecs, Hungary.
   [Hussain, Alizadeh; Szujo, Szabina] Univ Pecs, Dept Med 1, Dept Hematol, Pecs, Hungary.
   [Simon, Maria] Univ Pecs, Med Sch, Dept Psychiat & Psychotherapy, Pecs, Hungary.
C3 University of Pecs; University of Pecs; University of Pecs; Hungarian
   Academy of Sciences; Szeged University; University of Pecs; Szeged
   University; University of Pecs; University of Pecs; University of Pecs
RP Balaskó, M (corresponding author), Univ Pecs, Med Sch, Inst Translat Med, 1 Szigeti Str, H-7624 Pecs, Hungary.
EM marta.balasko@aok.pte.hu
RI Hartmann, Petra/AAZ-7881-2021; Hegyi, Péter/B-3163-2016; Garami,
   Andras/AAF-8588-2020
OI Matrai, Peter/0000-0001-5144-0733; Garami, Andras/0000-0003-2493-0571;
   Hartmann, Petra/0000-0002-4746-9792
FU European Union; Hungarian Government [EFOP-3.6.2-16-2017-0006];
   University of Pecs, Hungary [2017/12, 2017/13, PTE-AOK-KA-2015-14]
FX This work was supported by grants from the European Union and the
   Hungarian Government (EFOP-3.6.2-16-2017-0006 to P.H.) and from the
   University of Pecs, Hungary (PTE AOK-KA No: 2017/12 to E.P, PTE AOK-KA
   No: 2017/13 to M.B., and PTE-AOK-KA-2015-14 to M.S.).
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NR 87
TC 60
Z9 71
U1 0
U2 32
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
EI 1873-3360
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD SEP
PY 2018
VL 95
BP 63
EP 73
DI 10.1016/j.psyneuen.2018.05.014
PG 11
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA GU9YO
UT WOS:000445713400008
PM 29803182
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Lozovoy, MAB
   Simao, ANC
   Hohmann, MSN
   Simao, TNC
   Barbosa, DS
   Morimoto, HK
   Reiche, EMV
   Cecchini, R
   Dichi, I
AF Lozovoy, M. A. B.
   Simao, A. N. C.
   Hohmann, M. S. N.
   Simao, T. N. C.
   Barbosa, D. S.
   Morimoto, H. K.
   Reiche, E. M. V.
   Cecchini, R.
   Dichi, I.
TI Inflammatory biomarkers and oxidative stress measurements in patients
   with systemic lupus erythematosus with or without metabolic syndrome
SO LUPUS
LA English
DT Article
DE inflammatory biomarkers; metabolic syndrome; oxidative stress; systemic
   lupus erythematosus
ID TRADITIONAL RISK-FACTORS; CORONARY-HEART-DISEASE; INSULIN-RESISTANCE;
   CARDIOVASCULAR RISK; DENSITY-LIPOPROTEIN; ASSOCIATION; PREVALENCE;
   WOMEN; PROTEIN
AB The aims of the present study were to report the frequency of metabolic syndrome in systemic lupus erythematosus (SLE); to verify differences in inflammatory biomarkers and oxidative stress in SLE patients with or without metabolic syndrome; and to assess which metabolic syndrome components are associated with oxidative stress and disease activity. The study included 58 SLE patients and 105 controls. SLE patients were divided in two groups, with and without metabolic syndrome. 41.4% patients met the criteria for metabolic syndrome compared with 10.5% controls. Patients with SLE and metabolic syndrome had significantly raised serum uric acid, C-reactive protein (CRP), lipid hydroperoxides, and protein oxidation when compared with patients with SLE without metabolic syndrome. Lipid hydroperoxides were correlated with CRP, whereas protein oxidation was associated with waist circumference and uric acid. There was a positive association between serum C3 and C4 and glucose and between C3 and CRP. SLE disease activity index (SLEDAI) scores were positively correlated with body mass index (BMI) and waist circumference (WC). In conclusion, SLE patients have a high prevalence of metabolic syndrome and this syndrome directly contributes to increase inflammatory status and oxidative stress. Inflammatory processes, being overweight/obese, and uric acid may favor oxidative stress increases in patients with SLE and metabolic syndrome. C3 and C4 may have a positive acute-phase protein behavior in patients with SLE. Lupus (2011) 20, 1356-1364.
C1 [Lozovoy, M. A. B.] Univ N Parana UNOPAR, Dept Clin Anal, Londrina, Brazil.
   [Simao, A. N. C.; Hohmann, M. S. N.; Barbosa, D. S.; Morimoto, H. K.; Reiche, E. M. V.] Univ Londrina, Dept Pathol Clin Anal & Toxicol, Londrina, Brazil.
   [Simao, T. N. C.] Univ Norte Parana, Dept Nutr, Londrina, Brazil.
   [Cecchini, R.] Univ Londrina, Lab Pathophysiol Free Radicals, Londrina, Brazil.
   [Dichi, I.] Univ Londrina, Dept Internal Med, Londrina, Brazil.
C3 University Norte Parana; University Norte Parana
RP Simao, ANC (corresponding author), Univ Londrina, Dept Clin Pathol, Robert Koch Ave 60 Bairro Cervejaria, Londrina, Parana, Brazil.
EM deianame@yahoo.com.br
RI Simão, Andrea/AAM-4892-2021; Lozovoy, Marcell/AAM-4897-2021; Reiche,
   EDNa/AAD-4186-2020; Barbosa, Décio/AAE-6351-2019; Cecchini,
   Rubens/D-9811-2013; Reiche, Edna Maria Vissoci/C-4102-2013
OI Cecchini, Rubens/0000-0001-9941-2344; Reiche, Edna Maria
   Vissoci/0000-0001-6507-2839; Hohmann, Miriam Sayuri
   Nagashima/0000-0003-2667-3919
FU University of Londrina
FX This work was supported by the University of Londrina Research Funds
   (FAEPE).
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NR 35
TC 33
Z9 36
U1 1
U2 9
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0961-2033
EI 1477-0962
J9 LUPUS
JI Lupus
PD NOV
PY 2011
VL 20
IS 13
BP 1356
EP 1364
DI 10.1177/0961203311411348
PG 9
WC Rheumatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Rheumatology
GA 849DH
UT WOS:000297105200002
PM 21868433
DA 2025-06-11
ER

PT J
AU Song, J
   Kim, J
AF Song, Juhyun
   Kim, Jongpil
TI Role of Sirtuins in Linking Metabolic Syndrome with Depression
SO FRONTIERS IN CELLULAR NEUROSCIENCE
LA English
DT Review
DE sirtuins(SIRTs); depression; inflammation; neurotransmitter; synaptic
   dysfunction; metabolic syndrome
ID SIRT1 DEACETYLASE PROTECTS; CO-MORBID DEPRESSION; REGULATOR 1 PROTECTS;
   MEDIATED CELL-DEATH; CALORIC RESTRICTION; DIABETES-MELLITUS; COGNITIVE
   DYSFUNCTION; CEREBRAL METABOLISM; PREFRONTAL CORTEX; GABAERGIC NEURONS
AB Depression is now widely regarded as a common disabling disorder that affects negatively the social functioning all over the world. Depression is associated with diverse phenomenon in brain such as neuroinflammation, synaptic dysfunction, and cognitive deficit. Recent studies reported that depression occurs by various metabolic changes, leading to metabolic syndrome. Sirtuins (SIRTs) are NAD(+)-dependent class III histone deacetylases, known to regulate diverse biological mechanism such as longevity, genomic stability, and inflammation. The modulation of sirtuin activity has been highlighted as a promising approach to reduce neurodegenerative processes. In this review, we summarize the recent discoveries regarding the potential relationship between SIRTs and depression caused by metabolic disorders (Mets). Ultimately, we suggest the possibility that SIRTs will be novel targets to alleviate neuropathogenesis induced by depression.
C1 [Song, Juhyun; Kim, Jongpil] Dongguk Univ, Dept Biomed Engn, Seoul, South Korea.
C3 Dongguk University
RP Kim, J (corresponding author), Dongguk Univ, Dept Biomed Engn, Seoul, South Korea.
EM jk2316@gmail.com
RI Song, Juhyun/AAH-3162-2020
OI Song, Juhyun/0000-0002-9165-8507
FU National Research Foundation - Korea government [NRF-2013R1A1A10588 35,
   NRF-2013M3A9B4076485, NRF-2015M3A9B4051064]; Korea Health Technology R D
   Project; Ministry of Healthand Welfare [HI13C0540]; Next-Generation Bio
   Green 21 Program, Rural Development Administration [PJ01107701]
FX This work was supported by the National Research Foundation funded by
   the Korea government, (NRF-2013R1A1A10588 35),
   (NRF-2013M3A9B4076485),(NRF-2015M3A9B4051064), Korea Health Technology R
   & D Project, Ministry of Healthand Welfare (HI13C0540) and the
   Next-Generation Bio Green 21 Program, Rural Development Administration
   (PJ01107701).
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NR 142
TC 11
Z9 14
U1 0
U2 10
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1662-5102
J9 FRONT CELL NEUROSCI
JI Front. Cell. Neurosci.
PD MAR 31
PY 2016
VL 10
AR 86
DI 10.3389/fncel.2016.00086
PG 9
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology
GA FA6PT
UT WOS:000405567000003
PM 27065808
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Schwarz, PEH
   Reimann, M
   Li, J
   Bergmann, A
   Licinio, J
   Wong, ML
   Bornstein, S
AF Schwarz, P. E. H.
   Reimann, M.
   Li, J.
   Bergmann, A.
   Licinio, J.
   Wong, M. -L.
   Bornstein, S. R.
TI The metabolic syndrome - A global challenge for prevention
SO HORMONE AND METABOLIC RESEARCH
LA English
DT Review
DE metabolic syndrome; global health; prevention; type 2 diabetes;
   intervention
ID IMPAIRED GLUCOSE-TOLERANCE; TYPE-2 DIABETES-MELLITUS; LIFE-STYLE
   INTERVENTION; KAPPA-B ACTIVATION; ADIPOQ GENE; STRESS; REDUCTION;
   OBESITY; ASSOCIATION; DEPRESSION
AB In the last years we have learned a lot about the pathopysiology of a cluster of the diseases called Metabolic Syndrome but currently an exciting discussion debates the Metabolic Syndrome in a light of a mystery of medicine or a clinical paradigm with a controversary about diagnostic, treatment or preventive procedure. There is now convincing evidence that prevention is the most important and effective way to reduce the personal and socio-economic burden of the Metabolic Syndrome and its associated complications.Still, it is currently not clear how to implement preventive interventions into clinical practice but will require an integrated and transdisciplinary approach on an international level in order to efficiently reduce premature morbidity and mortality. Nevertheless, global strategies are still lacking but are needed to tackle inequalities in health between industrialized countries and the developing world. A global health strategy has to take into account political, epidemiological, environmental, infrastructural and genetic aspects. The Metabolic Syndrome is not a mystery - it is a clinical paradigm and global challenge.
C1 Tech Univ Dresden, Med Fac Carl Gustav Carus, Clin Endocrinol Diabet & Metabol, Dept Internal Med 3, D-01307 Dresden, Germany.
   Univ Miami, Miller Sch Med, Dept Psychiat & Behav Sci, Miami, FL USA.
C3 Technische Universitat Dresden; Carl Gustav Carus University Hospital;
   University of Miami
RP Schwarz, PEH (corresponding author), Tech Univ Dresden, Med Fac Carl Gustav Carus, Dept Med 3, Div Endocrinol, D-01307 Dresden, Germany.
EM peter.schwarz@unildinikum-dresden.de
RI Li, Jiang/M-4276-2014; Schwarz, Peter/B-5127-2013; Wong,
   Ma-Li/ABD-5525-2020; Wong, Ma-Li/D-7903-2011; Licinio, Julio/L-4244-2013
OI Wong, Ma-Li/0000-0003-1512-3073; Licinio, Julio/0000-0001-6905-5884
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NR 49
TC 53
Z9 56
U1 0
U2 10
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0018-5043
EI 1439-4286
J9 HORM METAB RES
JI Horm. Metab. Res.
PD NOV
PY 2007
VL 39
IS 11
BP 777
EP 780
DI 10.1055/s-2007-990312
PG 4
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 239VF
UT WOS:000251545700002
PM 17992630
OA Bronze
DA 2025-06-11
ER

PT J
AU Le Foll, B
   Trigo, JM
   Sharkey, KA
   Le Strat, Y
AF Le Foll, Bernard
   Trigo, Jose M.
   Sharkey, Keith A.
   Le Strat, Yann
TI Cannabis and Δ<SUP>9</SUP>-tetrahydrocannabinol (THC) for weight loss?
SO MEDICAL HYPOTHESES
LA English
DT Article
ID CB1 RECEPTOR ANTAGONIST; BODY-MASS INDEX; FOOD-INTAKE; ENDOCANNABINOID
   SYSTEM; CARDIOMETABOLIC RISK; TOLERANCE; OBESITY;
   DELTA-9-TETRAHYDROCANNABINOL; HYPERPHAGIA; REINFORCEMENT
AB Obesity is one of the highest preventable causes of morbidity and mortality in the developed world [1]. It has been well known for a long time that exposure to cannabis produces an increase of appetite (a phenomenon referred to as the 'munchies'). This phenomenon led to an exploration of the role of the endocannabinoid system in the regulation of obesity and associated metabolic syndrome. This effort subsequently led to the development of a successful therapeutic approach for obesity that consisted of blocking the cannabinoid CB1 receptors using ligands such as Rimonabant in order to produce weight loss and improve metabolic profile [2]. Despite being efficacious, Rimonabant was associated with increased rates of depression and anxiety and therefore removed from the market. We recently discovered that the prevalence of obesity is paradoxically much lower in cannabis users as compared to non-users and that this difference is not accounted for by tobacco smoking status and is still present after adjusting for variables such as sex and age. Here, we propose that this effect is directly related to exposure to the AY-tetrahydrocannabinol (THC) present in cannabis smoke. We therefore propose the seemingly paradoxical hypothesis that THC or a THC/cannabidiol combination drug may produce weight loss and may be a useful therapeutic for the treatment of obesity and its complications. (C) 2013 Elsevier Ltd. All rights reserved.
C1 [Le Foll, Bernard; Trigo, Jose M.; Le Strat, Yann] CAMH, Campbell Family Mental Hlth Res Inst, Translat Addict Res Lab, Toronto, ON, Canada.
   [Le Foll, Bernard] CAMH, Addict Program, Toronto, ON, Canada.
   [Le Foll, Bernard] Univ Toronto, Inst Med Sci, Dept Psychiat, Toronto, ON M5S 1A1, Canada.
   [Le Foll, Bernard] Univ Toronto, Inst Med Sci, Dept Pharmacol, Toronto, ON M5S 1A1, Canada.
   [Le Foll, Bernard] Univ Toronto, Inst Med Sci, Dept Family & Community Med, Toronto, ON M5S 1A1, Canada.
   [Sharkey, Keith A.] Univ Calgary, Dept Physiol & Pharmacol, Hotchkiss Brain Inst, Calgary, AB, Canada.
   [Le Strat, Yann] INSERM, U894, Team 1, Ctr Psychiat & Neurosci, Paris, France.
   [Le Strat, Yann] Univ Paris Diderot, Fac Med Bichat Lariboisiere, Sorbonne Paris Cite, Paris, France.
   [Le Strat, Yann] Hop Louis Mourier, AP HP, Dept Psychiat, F-92701 Colombes, France.
C3 University of Toronto; Centre for Addiction & Mental Health - Canada;
   University of Toronto; Centre for Addiction & Mental Health - Canada;
   University of Toronto; University of Toronto; University of Toronto;
   University of Calgary; Institut National de la Sante et de la Recherche
   Medicale (Inserm); Universite Paris Cite; Universite Paris Cite;
   Assistance Publique Hopitaux Paris (APHP); Universite Paris Cite;
   Hopital Universitaire Louis-Mourier - APHP
RP Le Foll, B (corresponding author), CAMH, Campbell Family Mental Hlth Res Inst, Translat Addict Res Lab, Toronto, ON, Canada.
EM bernard.lefoll@camh.ca
RI Le Strat, Yann/C-9848-2013; Sharkey, Keith/HLX-7515-2023; trigo,
   jose/C-2770-2011; Le Foll, Bernard/K-2952-2014
OI Le Foll, Bernard/0000-0002-6406-4973; Sharkey, Keith/0000-0001-9560-1711
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NR 54
TC 44
Z9 50
U1 0
U2 48
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0306-9877
EI 1532-2777
J9 MED HYPOTHESES
JI Med. Hypotheses
PD MAY
PY 2013
VL 80
IS 5
BP 564
EP 567
DI 10.1016/j.mehy.2013.01.019
PG 4
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 131LK
UT WOS:000317995000012
PM 23410498
DA 2025-06-11
ER

PT J
AU Gardner, J
   Swarbrick, M
   Ackerman, A
   Church, T
   Rios, V
   Valente, L
   Rutledge, J
AF Gardner, Jennifer
   Swarbrick, Margaret
   Ackerman, Ariane
   Church, Theodora
   Rios, Vanessa
   Valente, Laura
   Rutledge, John
TI Effects of Physical Limitations on Daily Activities Among Adults With
   Mental Health Disorders Opportunities for Nursing and Occupational
   Therapy Interventions
SO JOURNAL OF PSYCHOSOCIAL NURSING AND MENTAL HEALTH SERVICES
LA English
DT Article
ID METABOLIC SYNDROME; PREVALENCE; PEOPLE
AB Individuals living with mental health disorders served by the public mental health system often face comorbid medical conditions that affect their quality of life and lifespan. The effect of physical limitations on the engagement in daily activities among individuals living with mental health disorders has not been extensively researched. Adults attending community wellness centers (N = 53) in a northeastern United State were included in a descriptive study exploring the impact of physical limitations on daily activities. The activities most frequently affected were: walking or moving around, sleeping, and finding a job. The physical limitations affecting these three activities were lack of energy and pain. Health care professionals, including mental health nurses and occupational therapy practitioners, are in an ideal position to collaborate by evaluating and offering treatment interventions that address physical limitations to positively affect occupational functioning and recovery.
C1 [Gardner, Jennifer] Kean Univ, Dept Occupat Therapy, 1000 Morris Ave,EC 224, Union, NJ 07083 USA.
   [Swarbrick, Margaret] Rutgers Univ Behav Hlth Care, Piscataway, NJ USA.
   [Swarbrick, Margaret] New Jersey Wellness, Collaborat Support Programs, Freehold, NJ USA.
   [Church, Theodora] Kessler Inst Rehabil, W Orange, NJ USA.
   [Rios, Vanessa] Sunny Days Sunshine Ctr, Manalapan Township, NJ USA.
   [Valente, Laura] Childrens Specialized Hosp, Mountainside, NJ USA.
   [Rutledge, John] Valley Hosp, Ridgewood, NJ USA.
   [Ackerman, Ariane] St Josephs Med Ctr, Yonkers, NY USA.
C3 Kean University; Rutgers University System; Rutgers University New
   Brunswick; Rutgers University Biomedical & Health Sciences; Kessler
   Institute for Rehabilitation
RP Gardner, J (corresponding author), Kean Univ, Dept Occupat Therapy, 1000 Morris Ave,EC 224, Union, NJ 07083 USA.
EM jengardn@kean.edu
CR Albert U, 2013, GEN HOSP PSYCHIAT, V35, P154, DOI 10.1016/j.genhosppsych.2012.10.004
   American Occupational Therapy Association (AOTA), 2014, AM J OCCUP THER, V68, pS1, DOI [10.5014/ajot.2014.682006, DOI 10.5014/AJOT.2014.682006]
   Buhagiar K, 2011, BMC PSYCHIATRY, V11, DOI 10.1186/1471-244X-11-104
   Cook S, 2009, BRIT J OCCUP THER, V72, P238, DOI 10.1177/030802260907200602
   Gardner J., 2015, OCCUPATIONAL E UNPUB
   Glover CM, 2013, PSYCHIATR REHABIL J, V36, P45, DOI 10.1037/h0094747
   Green A., 2008, British Journal of Occupational Therapy, V71, P196, DOI [DOI 10.1177/030802260807100506, 10.1177/030802260807100506]
   Gurpegui M, 2012, PROG NEURO-PSYCHOPH, V37, P169, DOI 10.1016/j.pnpbp.2012.01.014
   Holmberg K, 2006, ACTA PAEDIATR, V95, P664, DOI 10.1080/08035250600717121
   Kahl KG, 2013, EUR ARCH PSY CLIN N, V263, P205, DOI 10.1007/s00406-012-0339-2
   Kelly T, 2013, J AFFECT DISORDERS, V151, P54, DOI 10.1016/j.jad.2013.05.047
   Keuroghlian AS, 2013, J PSYCHIATR RES, V47, P1499, DOI 10.1016/j.jpsychires.2013.06.012
   Lin WC, 2011, J AM GERIATR SOC, V59, P1913, DOI 10.1111/j.1532-5415.2011.03588.x
   O'Hea E., 2012, LEARNING HLTH LIVING
   Pentland W, 2003, PSYCHIATR REHABIL J, V26, P290, DOI 10.2975/26.2003.290.302
   Shaw WS, 2010, PAIN MED, V11, P1391, DOI 10.1111/j.1526-4637.2010.00934.x
   Stray LL, 2013, BEHAV BRAIN FUNCT, V9, DOI 10.1186/1744-9081-9-18
NR 17
TC 3
Z9 3
U1 0
U2 10
PU SLACK INC
PI THOROFARE
PA 6900 GROVE RD, THOROFARE, NJ 08086 USA
SN 0279-3695
EI 1938-2413
J9 J PSYCHOSOC NURS MEN
JI J. Psychosoc. Nurs. Ment. Health Serv.
PD OCT
PY 2017
VL 55
IS 10
BP 45
EP 51
DI 10.3928/02793695-20170818-05
PG 7
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA FP5QS
UT WOS:000417674600006
PM 28840935
DA 2025-06-11
ER

PT J
AU Frisbee, SJ
   Singh, SS
   Jackson, DN
   Lemaster, KA
   Milde, SA
   Shoemaker, JK
   Frisbee, JC
AF Frisbee, Stephanie J.
   Singh, Sarah S.
   Jackson, Dwayne N.
   Lemaster, Kent A.
   Milde, Samantha A.
   Shoemaker, J. Kevin
   Frisbee, Jefferson C.
TI Beneficial Pleiotropic Antidepressive Effects of Cardiovascular Disease
   Risk Factor Interventions in the Metabolic Syndrome
SO JOURNAL OF THE AMERICAN HEART ASSOCIATION
LA English
DT Article
DE depression; metabolic syndrome; peripheral vascular disease
ID CHRONIC MILD STRESS; MAJOR DEPRESSIVE DISORDER; MICROVASCULAR
   RAREFACTION; SKELETAL-MUSCLE; VASCULAR DYSFUNCTION; RESISTANCE ARTERIES;
   REACTIVITY; EXERCISE; BEHAVIOR; MODEL
AB BackgroundAlthough the increased prevalence and severity of clinical depression and elevated cardiovascular disease risk represent 2 vexing public health issues, the growing awareness of their combined presentation compounds the challenge. The obese Zucker rat, a model of the metabolic syndrome, spontaneously develops significant depressive symptoms in parallel with the progression of the metabolic syndrome and, thus, represents a compelling model for study. The primary objective was to assess the impact on both cardiovascular outcomes, specifically vascular structure and function, and depressive symptoms in obese Zucker rats after aggressive treatment for cardiovascular disease risk factors with long-term exercise or targeted pharmacological interventions.
   Methods and ResultsWe chronically treated obese Zucker rats with clinically relevant interventions against cardiovascular disease risk factors to determine impacts on vascular outcomes and depressive symptom severity. While most of the interventions (chronic exercise, anti-hypertensive, the interventions (long-term exercise, antihypertensive, antidyslipidemia, and antidiabetic) were differentially effective at improving vascular outcomes, only those that also resulted in a significant improvement to oxidant stress, inflammation, arachidonic acid metabolism (prostacyclin versus thromboxane A(2)), and their associated sequelae were effective at also blunting depressive symptom severity. Using multivariable analyses, discrimination between the effectiveness of treatment groups to maintain behavioral outcomes appeared to be dependent on breaking the cycle of inflammation and oxidant stress, with the associated outcomes of improving endothelial metabolism and both cerebral and peripheral vascular structure and function.
   ConclusionsThis initial study provides a compelling framework from which to further interrogate the links between cardiovascular disease risk factors and depressive symptoms and suggests mechanistic links and potentially effective avenues for intervention.
C1 [Frisbee, Stephanie J.] Univ Western Ontario, Schulich Sch Med & Dent, Dept Pathol & Lab Med, 1151 Richmond St,Dent Sci Bldg,Room 4041, London, ON N6A 5C1, Canada.
   [Frisbee, Stephanie J.; Singh, Sarah S.] Univ Western Ontario, Schulich Sch Med & Dent, Dept Epidemiol & Biostat, London, ON, Canada.
   [Jackson, Dwayne N.; Lemaster, Kent A.; Frisbee, Jefferson C.] Univ Western Ontario, Schulich Sch Med & Dent, Dept Med Biophys, London, ON, Canada.
   [Milde, Samantha A.; Shoemaker, J. Kevin; Frisbee, Jefferson C.] Univ Western Ontario, Schulich Sch Med & Dent, Dept Physiol & Pharmacol, London, ON, Canada.
   [Shoemaker, J. Kevin] Univ Western Ontario, Fac Hlth Sci, Sch Kinesiol, London, ON, Canada.
C3 Western University (University of Western Ontario); Western University
   (University of Western Ontario); Western University (University of
   Western Ontario); Western University (University of Western Ontario);
   Western University (University of Western Ontario)
RP Frisbee, SJ (corresponding author), Univ Western Ontario, Schulich Sch Med & Dent, Dept Pathol & Lab Med, 1151 Richmond St,Dent Sci Bldg,Room 4041, London, ON N6A 5C1, Canada.
EM sfrisbee@uwo.ca
RI Jackson, Dwayne/E-4153-2015; Shoemaker, Kevin/L-2682-2013
OI Frisbee, Stephanie/0000-0003-1526-1839; Frisbee,
   Jefferson/0000-0003-2751-0599; Shoemaker, Kevin/0000-0002-6794-5979
FU American Heart Association [IRG 14330015, PRE 16850005, EIA 0740129N];
   National Institutes of Health [RR 2865AR, R01 DK 64668]; Natural
   Sciences and Engineering Research Council [R4218A03]
FX This study was supported by the American Heart Association (IRG
   14330015, PRE 16850005, and EIA 0740129N), the National Institutes of
   Health (RR 2865AR and R01 DK 64668), and the Natural Sciences and
   Engineering Research Council (R4218A03).
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NR 69
TC 8
Z9 9
U1 1
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
EI 2047-9980
J9 J AM HEART ASSOC
JI J. Am. Heart Assoc.
PD APR 3
PY 2018
VL 7
IS 7
AR e008185
DI 10.1161/JAHA.117.008185
PG 37
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA GC7YC
UT WOS:000430009000025
PM 29581223
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Altintas, E
   Yigit, F
   Taskintuna, N
AF Altintas, Ebru
   Yigit, Fatma
   Taskintuna, Nilgun
TI The impact of psychiatric disorders with cardiac syndrome X on quality
   of life: 3 months prospective study
SO INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
LA English
DT Article
DE Cardiac syndrome X; psychiatric comorbidity; quality of life
ID NONCARDIAC CHEST-PAIN; NORMAL CORONARY ANGIOGRAMS; ARTERIES; DISEASE;
   IMIPRAMINE; MORBIDITY; INVENTORY; ANGINA
AB The aim of the study is to investigate the impact of psychiatric disorders with cardiac syndrome X (CSX) on the patients' quality of life, as well as the efficacy of psychiatric support. Fifty-six CSX and fifty-three Coronary Heart Disease patients were included in the study after coronary angiography. Patients were evaluated right after the angiography and 3 months thereafter. The socio-demographic characteristics, comorbid disorders, Beck Anxiety (BAI), Depression (BDI) Inventory, and Health Related Quality of Life (SF-36) were compared between groups. The most common mental disorders was depression which account for 41%, the next were anxiety disorders (64%, n = 36) and somatoform (24%, n = 14). Initially, BAI, BDI in the CSX group were significantly higher when compared to the control group. There was significant difference in all subgroups of SF-36 at the end of the second evaluation versus the first evaluation in the CSX patients. The present study revealed that patients with CSX have higher prevalence of psychiatric comorbidities and lower quality of life. Psychiatric approaches are benefit for CSX patients to improvement their quality of life.
C1 [Altintas, Ebru; Taskintuna, Nilgun] Baskent Univ, Fac Med, Dept Psychiat, TR-01250 Adana, Turkey.
   [Yigit, Fatma] Baskent Univ, Fac Med, Dept Cardiol, TR-01250 Adana, Turkey.
C3 Baskent University; Baskent University
RP Altintas, E (corresponding author), Baskent Univ, Fac Med, Dept Psychiat, Dadaloglu Mah Serinevler 2591 Sk 4, TR-01250 Adana, Turkey.
EM yurdagule-bru@hotmail.com
RI Altintas, Ebru/G-8832-2015; yigit, fatma/ABC-8170-2021
OI Altintas, Ebru/0000-0003-2735-4805; yigit, fatma/0000-0003-1541-6167
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NR 32
TC 16
Z9 16
U1 0
U2 1
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 1940-5901
J9 INT J CLIN EXP MED
JI Int. J. Clin. Exp. Med.
PY 2014
VL 7
IS 10
BP 3520
EP 3527
PG 8
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Research & Experimental Medicine
GA AT7MK
UT WOS:000345121100050
PM 25419392
DA 2025-06-11
ER

PT J
AU Jeon, JS
   Lee, SY
   Ahn, SC
   Kim, YJ
   Lee, JG
   Yi, YH
AF Jeon, Jeong Suk
   Lee, Sang Yeoup
   Ahn, Soon Cheol
   Kim, Yun Jin
   Lee, Jeong Gyu
   Yi, Yu Hyeon
TI Temporal Changes of Metabolic Indicators and Quality of Life by a
   Two-Day Patient Education Program for Metabolic Syndrome Patients
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Article
DE education; health; metabolic syndrome; nutrition; patient; physical
   activity
ID PHYSICAL-ACTIVITY; RELIABILITY; DEPRESSION; VALIDITY; CAMP
AB Metabolic syndrome (MetS) is a disease with a high prevalence that threatens the health of modern people. Patient education is essential to control MetS. This prospective study aimed to evaluate 6-month changes in health indicators following a two-day education program for patients with MetS aged 45 or older. Education about MetS, lifestyle modification, nutrition, and physical activity was provided. At 3 and 6 months after the program, participants visited for follow-up. Twenty-two patients completed the 6-month study. Waist circumference was reduced, and life quality and depression index improved in 3 and 6 months compared to pre-education. Blood pressure decreased, and anxiety index improved at three months. Nutritional knowledge was well maintained for 3 and 6 months. High-density lipoprotein-cholesterol levels increased at six months. Three out of twenty-two patients did not satisfy MetS criteria at the end of the study due to improved indicators. A two-day multidisciplinary education program positively affected health indicators in MetS patients. Participation in the program also help with life satisfaction and positive emotional condition. However, some indicators improved in 3 months, but the effect disappeared 6 months after the program.
C1 [Jeon, Jeong Suk] Bongseng Mem Hosp, Family Med Clin, Busan 48775, South Korea.
   [Lee, Sang Yeoup] Pusan Natl Univ, Yangsan Hosp, Family Med Clin, Yangsan 50612, South Korea.
   [Lee, Sang Yeoup] Pusan Natl Univ, Yangsan Hosp, Biomed Res Inst, Yangsan 50612, South Korea.
   [Lee, Sang Yeoup] Pusan Natl Univ, Dept Med Educ, Sch Med, Yangsan 50612, South Korea.
   [Ahn, Soon Cheol] Pusan Natl Univ, Dept Microbiol & Immunol, Sch Med, Yangsan 50612, South Korea.
   [Kim, Yun Jin; Lee, Jeong Gyu; Yi, Yu Hyeon] Pusan Natl Univ, Dept Family Med, Sch Med, Yangsan 50612, South Korea.
C3 Pusan National University; Pusan National University Hospital; Pusan
   National University; Pusan National University Hospital; Pusan National
   University; Pusan National University; Pusan National University
RP Lee, SY (corresponding author), Pusan Natl Univ, Yangsan Hosp, Family Med Clin, Yangsan 50612, South Korea.; Lee, SY (corresponding author), Pusan Natl Univ, Yangsan Hosp, Biomed Res Inst, Yangsan 50612, South Korea.; Lee, SY (corresponding author), Pusan Natl Univ, Dept Med Educ, Sch Med, Yangsan 50612, South Korea.
EM dalkiiis@hanmail.net; saylee@pnu.edu; ahnsc@pusan.ac.kr;
   yujkim@pusan.ac.kr; eltidine@hanmail.net; eeugus@hanmail.net
RI Kisa, Adnan/Q-2081-2019; Lee, Sang Yeoup/IZE-0083-2023
OI Lee, Sang Yeoup/0000-0002-3585-9910; Yi, Yu Hyeon/0000-0002-1786-2737
CR Due-Christensen M, 2012, DIABETIC MED, V29, P251, DOI 10.1111/j.1464-5491.2011.03521.x
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NR 20
TC 2
Z9 3
U1 0
U2 2
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD MAR
PY 2022
VL 19
IS 6
AR 3351
DI 10.3390/ijerph19063351
PG 9
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA 0C4FS
UT WOS:000775271600001
PM 35329038
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Baghdadi, LR
   Alhassan, MK
   Alotaibi, FH
   AlSelaim, KB
   Alzahrani, AA
   AlMusaeed, FF
AF Baghdadi, Leena R.
   Alhassan, Mohammed Khalid
   Alotaibi, Fawaz Hindi
   AlSelaim, Khalid Badr
   Alzahrani, Abdulrahman Abdulkhaliq
   AlMusaeed, Faisal Fahad
TI Anxiety, Depression, and Common Chronic Diseases, and Their Association
   With Social Determinants in Saudi Primary Care
SO JOURNAL OF PRIMARY CARE AND COMMUNITY HEALTH
LA English
DT Article
DE depression; anxiety; hypertension; diabetes; rheumatoid arthritis;
   social determinants; lifestyle; prevalence; primary care; Saudi Arabia
ID METABOLIC SYNDROME; HEALTH; SYMPTOMS; EPIDEMIOLOGY; COMORBIDITY;
   SMOKING; ADULTS
AB Introduction: Patients with chronic diseases can experience psychological conditions, including anxiety and depression. However, the association between chronic diseases and these psychological conditions remains unclear. This study aimed to identify the relationship between anxiety, depression, and common chronic diseases (hypertension, type 2 diabetes, dyslipidemia, and rheumatoid arthritis), and their association with social determinants at an outpatient primary care setting. Methods: The validated hospital anxiety and depression scale was administered electronically to eligible participants. For each condition (anxiety and depression), participants were categorized as normal, borderline abnormal, and abnormal, according to their score out of 21 (<= 7 = normal, 8-10 = borderline abnormal, >= 11 = abnormal). The scores and numbers of participants in each category were analyzed and compared with their demographic characteristics and chronic diseases for associations and relationships. Results: We recruited 271 participants (mean age of 51.65 + 11.71 years) attending primary care clinics. Of these patients, 17.7% and 8.9% had borderline abnormal and abnormal depression, respectively, and 10.3% and 8.9% of patients had borderline abnormal anxiety and abnormal anxiety. Common social determinants and lifestyle factors were examined. Age, gender, and sugary drinks' consumption significantly increased the odds of hypertension and type 2 diabetes; vigorous physical activity 3 times a week, decreased the odds of developing these chronic diseases. Adjusted regression models showed a statistically significant association between the hospital anxiety and depression scale score for borderline and abnormal anxiety and the presence of type 2 diabetes (OR 3.04 [95% CI 1.13, 8.19], P-value = .03 and OR 4.65 [95% CI 1.63,13.22], P-value <.03, respectively) and dyslipidemia (OR 5.93 [95% CI 1.54, 22.86], P-value = .01, and OR 4.70 [95% CI 0.78, 28.35], P-value = .09, respectively). The odds of developing depression were 4 times higher (P-value .04) in patients with rheumatoid arthritis. Conclusion: Among patients attending primary care outpatient clinics, anxiety, and depression were significantly associated with type 2 diabetes and rheumatoid arthritis, respectively. Social determinants and lifestyle factors play a major role in the development of common chronic diseases in Saudi Arabia. Primary care physicians should consider the patients' psychological status, sociodemographic status, and lifestyle risks during the management of chronic diseases.
C1 [Baghdadi, Leena R.; Alhassan, Mohammed Khalid; Alotaibi, Fawaz Hindi; AlSelaim, Khalid Badr; Alzahrani, Abdulrahman Abdulkhaliq; AlMusaeed, Faisal Fahad] King Saud Univ, Riyadh, Saudi Arabia.
C3 King Saud University
RP Baghdadi, LR (corresponding author), King Saud Univ, Coll Med, Dept Family & Commun Med, POB 7805, Riyadh 11472, Saudi Arabia.
EM lbaghdadi@ksu.edu.sa
RI Baghdadi, Leena/ABC-8527-2020; Alhassan, Mohammed/IZE-5754-2023
OI Alhassan, Mohammed/0000-0003-4122-9912; AlSelaim,
   Khalid/0000-0002-8523-1857
FU Deanship of Scientific Research at King Saud University
FX The authors extend their appreciation to the Deanship of Scientific
   Research at King Saud University for funding this work through the
   undergraduate Research Support Program.
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NR 41
TC 10
Z9 10
U1 1
U2 3
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 2150-1319
EI 2150-1327
J9 J PRIM CARE COMMUNIT
JI J. Prim. Care Community Health
PD NOV
PY 2021
VL 12
AR 21501327211054987
DI 10.1177/21501327211054987
PG 12
WC Primary Health Care
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA XJ1KP
UT WOS:000726556300001
PM 34814776
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Shrestha, N
   Parker, A
   Jurakic, D
   Biddle, SJH
   Pedisic, Z
AF Shrestha, Nipun
   Parker, Alexandra
   Jurakic, Danijel
   Biddle, Stuart J. H.
   Pedisic, Zeljko
TI Improving Practices of Mental Health Professionals in Recommending More
   Physical Activity and Less Sedentary Behaviour to Their Clients: An
   Intervention Trial
SO ISSUES IN MENTAL HEALTH NURSING
LA English
DT Article
ID PRIMARY-CARE; METABOLIC SYNDROME; PEOPLE; NURSES; SLEEP; NEEDS;
   SCHIZOPHRENIA; DISORDERS; MORTALITY; PROMOTION
AB We investigated the effects of increasing physical activity (PA) and reducing sedentary behaviour (SB) of mental health professionals on their attitudes towards and practices in recommending more PA and less SB to their clients. A 4-week pre-post intervention trial was conducted involving 17 mental health professionals. The participants who increased their own physical activity during the intervention increased the frequency of recommending more PA (p = 0.009) and less SB (p = 0.005) to their clients. A relatively simple, low-cost intervention, consisting of group behaviour change counselling, goal setting and positive feedback, may improve the practices of mental health professionals.
C1 [Shrestha, Nipun; Parker, Alexandra; Pedisic, Zeljko] Victoria Univ, Inst Hlth & Sport, Melbourne, Vic 8001, Australia.
   [Parker, Alexandra] Univ Melbourne, Ctr Youth Mental Hlth, Melbourne, Vic, Australia.
   [Jurakic, Danijel] Univ Zagreb, Fac Kinesiol, Zagreb, Croatia.
   [Biddle, Stuart J. H.] Univ Southern Queensland, Ctr Hlth Res, Physically Act Lifestyles Res Grp USQ Pals, Springfield Central, Australia.
C3 Victoria University; University of Melbourne; Orygen, The National
   Centre of Excellence in Youth Mental Health; University of Zagreb;
   University of Zagreb, Faculty of Kinesiology; University of Southern
   Queensland
RP Pedisic, Z (corresponding author), Victoria Univ, Inst Hlth & Sport, Melbourne, Vic 8001, Australia.
EM zeljko.pedisic@vu.edu.au
RI Pedisic, Zeljko/E-9753-2010; Biddle, Stuart/AAE-9395-2019; Shrestha,
   Nipun/MYS-3289-2025; Parker, Alexandra/AER-0997-2022; Jurakic,
   Danijel/AAM-5005-2020
OI Biddle, Stuart/0000-0002-7663-6895; Shrestha, Nipun/0000-0003-3542-8130;
   Parker, Alexandra/0000-0002-2398-6306
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NR 45
TC 2
Z9 2
U1 1
U2 8
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 0161-2840
EI 1096-4673
J9 ISSUES MENT HEALTH N
JI Issues Ment. Health Nurs.
PD MAR 4
PY 2022
VL 43
IS 3
BP 258
EP 264
DI 10.1080/01612840.2021.1972189
EA AUG 2021
PG 7
WC Nursing; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Psychiatry
GA ZF9ZU
UT WOS:000696459700001
PM 34529551
DA 2025-06-11
ER

PT J
AU Porcu, M
   Urbano, MR
   Verri, WA
   Barbosa, DS
   Baracat, M
   Vargas, HO
   Machado, RCBR
   Pescim, RR
   Nunes, SOV
AF Porcu, Mauro
   Urbano, Mariana Ragassi
   Verri, Waldiceu A., Jr.
   Barbosa, Decio Sabbatini
   Baracat, Marcela
   Vargas, Heber Odebrecht
   Bueno Rezende Machado, Regina Celia
   Pescim, Rodrigo Rossetto
   Vargas Nunes, Sandra Odebrecht
TI Effects of adjunctive N-acetylcysteine on depressive symptoms:
   Modulation by baseline high-sensitivity C-reactive protein
SO PSYCHIATRY RESEARCH
LA English
DT Article
DE Bipolar depression; Depression; Inflammation; Biomarkers;
   N-acetyl-cysteine; Clinical trial; C-reactive protein
ID QUALITY-OF-LIFE; BIPOLAR DISORDER; ACETYL CYSTEINE; PORTUGUESE VERSION;
   INFLAMMATION; RELIABILITY; DISABILITY; PATHWAYS; VALIDITY; STRESS
AB Outcomes in a RCTs of 12 weeks of theclinical efficacy of N-acetylcysteine (NAC) as an adjunctive treatment on depression and anxiety symptoms and its effects on high-sensitivity C-reactive protein (hs-CRP) levels. A wide array of measures were made. The 17-item version of the Hamilton Depression Rating Scale (HDRS17); the Hamilton Anxiety Rating Scale (HAM-A); Sheehan Disability Scale; Quality of Life; Clinical Global Impression (CGI); anthropometrics measures; and vital signs and biochemical laboratory. There were no significant differences among the groups regarding demographic, clinical features, use of medication, metabolic syndrome and comorbidities. From baseline to week 12, individuals receiving NAC, versus placebo, had a statistically significant reduction in depressive symptoms on HDRS17 (p < 0.01) and anxiety symptoms on HAM-A (p = 0.04), but only for individuals with levels of hs-CRP > 3 mg/L at baseline. Individuals receiving NAC with baseline levels of hs-CRP > 3 mg/L, had more significant reduction in uric acid levels compared to individuals with baseline levels of hs-CRP <= 3 mg/L on week 12. Participants receiving placebogained significantly more weight during the 12 weeks for baseline levels of hs-CRP <= 3 mg/L and hs-CRP > 3 mg/L, and individuals receiving NAC in both groups did not have significant weight change during the 12 weeks. No individuals were withdrawn from the study because of adverse event. NAC group exhibited significantly greater reduction on hs-CRP levels than placebo group from baseline to week 12. Trial registration: clinicaltrials.gov Identifier; NCT02252341
C1 [Vargas, Heber Odebrecht; Vargas Nunes, Sandra Odebrecht] Univ Estadual Londrina, Univ Hosp, Hlth Sci Ctr, Dept Clin Med,Psychiat Unit, Londrina, Parana, Brazil.
   [Porcu, Mauro; Barbosa, Decio Sabbatini; Vargas, Heber Odebrecht; Bueno Rezende Machado, Regina Celia; Vargas Nunes, Sandra Odebrecht] Univ Estadual Londrina, Univ Hosp, Ctr Approach & Treatment Smokers, Londrina, Parana, Brazil.
   [Barbosa, Decio Sabbatini] Univ Estadual Londrina, Dept Clin Anal & Toxicol, Londrina, Parana, Brazil.
   [Porcu, Mauro; Urbano, Mariana Ragassi; Verri, Waldiceu A., Jr.; Barbosa, Decio Sabbatini; Baracat, Marcela; Vargas, Heber Odebrecht; Bueno Rezende Machado, Regina Celia; Vargas Nunes, Sandra Odebrecht] Univ Estadual Londrina, Hlth Sci Ctr, Hlth Sci Grad Program, Londrina, Parana, Brazil.
   [Verri, Waldiceu A., Jr.] Univ Estadual Londrina, Ctr Biol Sci, Dept Pathol, Londrina, Parana, Brazil.
   [Urbano, Mariana Ragassi; Pescim, Rodrigo Rossetto] Univ Estadual Londrina, Exact Sci Ctr, Dept Stat, Londrina, Parana, Brazil.
C3 Universidade Estadual de Londrina; Universidade Estadual de Londrina;
   Universidade Estadual de Londrina; Universidade Estadual de Londrina;
   Universidade Estadual de Londrina; Universidade Estadual de Londrina
RP Porcu, M (corresponding author), Univ Estadual Londrina, Hlth Sci Ctr, Hlth Sci Grad Program, Londrina, Parana, Brazil.
EM mporcu@uol.com.br
RI Pescim, Rodrigo/F-3834-2017; Nunes, Sandra/B-4035-2019; PORCU,
   MAURO/HNR-3476-2023; Urbano, Mariana/AAQ-5622-2021; Barbosa,
   Décio/AAE-6351-2019; Verri, Waldiceu/I-1330-2013; Baracat, Marcela
   Maria/P-4957-2015
OI Urbano, Mariana/0000-0002-5411-5554; Odebrecht Vargas Nunes,
   Sandra/0000-0003-4851-6121; Verri, Waldiceu/0000-0003-2756-9283; Pescim,
   Rodrigo/0000-0001-6070-4702; Baracat, Marcela Maria/0000-0002-7109-7191
FU Health Sciences Postgraduate Program at Londrina State University,
   Parana, Brazil (UEL); Ministry for Science and Technology of Brazil
   (CNPq); CNPq [470344/2013-0, 465928/2014-5]; FAEPE UEL [01/2015]
FX This study was supported by Health Sciences Postgraduate Program at
   Londrina State University, Parana, Brazil (UEL), and Ministry for
   Science and Technology of Brazil (CNPq). CNPq number 470344/2013-0, CNPq
   number 465928/2014-5 and FAEPE UEL No 01/2015
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NR 38
TC 34
Z9 35
U1 0
U2 5
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0165-1781
J9 PSYCHIAT RES
JI Psychiatry Res.
PD MAY
PY 2018
VL 263
BP 268
EP 274
DI 10.1016/j.psychres.2018.02.056
PG 7
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA GF8PK
UT WOS:000432234600043
PM 29605103
DA 2025-06-11
ER

PT J
AU Bivanco-Lima, D
   Santos, ID
   Vannucchi, AMC
   Ribeiro, MCSD
AF Bivanco-Lima, Danielle
   Santos, Itamar de Souza
   Cortez Vannucchi, Ana Maria
   Sampaio de Almeida Ribeiro, Manoel Carlos
TI Cardiovascular risk in individuals with depression
SO REVISTA DA ASSOCIACAO MEDICA BRASILEIRA
LA English
DT Review
DE Cardiovascular disease; Risk factors; Depressive disorder; Depression
ID ALL-CAUSE MORTALITY; MAJOR DEPRESSION; HEART-DISEASE;
   PSYCHIATRIC-DISORDERS; METABOLIC SYNDROME; EXCESS MORTALITY;
   NATIONAL-HEALTH; MEDICAL-CARE; ANXIETY; SYMPTOMS
AB Depression and cardiovascular diseases (CVD) are both common illnesses. Several studies demonstrated that depressed individuals have higher mortality compared to age-and gender-matched population, with an excess of cardiovascular deaths. There is a bidirectional association between depression and CVD. Several factors can interact and influence this relationship: poverty and social inequality, reduced accessibility to health care, biological alterations (as reduced heart rate variability, endothelial dysfunction, increased inflammation and platelet function, and hyperactivity of hypothalamic-pituitary-adrenal axis), side effects of psychiatric medication, lower adherence to medical treatments, and higher frequency of cardiovascular risk factors (higher tobacco use, physical inactivity, obesity, diabetes mellitus). This article aims to update the current evidence of the possible mechanisms involved in the association between depression and CVD. (C) 2013 Elsevier Editora Ltda. All rights reserved.
C1 [Bivanco-Lima, Danielle; Cortez Vannucchi, Ana Maria] Ctr Saude Escola Barra Funda Dr Alexandre Vranjac, BR-01133020 Sao Paulo, Brazil.
   [Santos, Itamar de Souza; Sampaio de Almeida Ribeiro, Manoel Carlos] Univ Sao Paulo, Sch Med, Sao Paulo, Brazil.
   [Sampaio de Almeida Ribeiro, Manoel Carlos] Fac Ciencias Med Santa Casa Sao Paulo, Dept Social Med, Sao Paulo, Brazil.
C3 Universidade de Sao Paulo; Faculdade de Ciencias Medicas Santa Casa de
   Sao Paulo
RP Bivanco-Lima, D (corresponding author), Ctr Saude Escola Barra Funda Dr Alexandre Vranjac, Rua Dr Abraao Ribeiro 283, BR-01133020 Sao Paulo, Brazil.
EM danielle.bivanco@gmail.com
RI Bivanco-Lima, Danielle/G-6581-2015; Ribeiro, Manoel/H-6894-2012; Santos,
   Itamar/K-7055-2012
OI Santos, Itamar/0000-0003-3212-8466
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NR 58
TC 24
Z9 27
U1 1
U2 31
PU ASSOC MEDICA BRASILEIRA
PI SAO PAULO
PA RUA SAO CARLOS DO PINHAL 324, CAIXA POSTAL 8904, SAO PAULO, SP, BRAZIL
EI 1806-9282
J9 REV ASSOC MED BRAS
JI Rev. Assoc. Med. Bras.
PD MAY-JUN
PY 2013
VL 59
IS 3
BP 298
EP 304
DI 10.1016/j.ramb.2012.12.006
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 182KX
UT WOS:000321742300018
PM 23684214
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Meyer, JM
   Nasrallah, HA
   McEvoy, JP
   Goff, DC
   Davis, SM
   Chakos, M
   Patel, JK
   Keefe, RSE
   Stroup, TS
   Lieberman, JA
AF Meyer, JM
   Nasrallah, HA
   McEvoy, JP
   Goff, DC
   Davis, SM
   Chakos, M
   Patel, JK
   Keefe, RSE
   Stroup, TS
   Lieberman, JA
TI The Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE)
   Schizophrenia Trial: Clinical comparison of subgroups with and without
   the metabolic syndrome
SO SCHIZOPHRENIA RESEARCH
LA English
DT Article
DE schizophrenia; metabolic syndrome; health; rating; comorbidity
ID PITUITARY-ADRENAL AXIS; 3RD NATIONAL-HEALTH; CORONARY-HEART-DISEASE;
   EXCESS MORTALITY; PHYSICAL HEALTH; MEDICAL COMORBIDITY; STOCKHOLM
   COUNTY; RISK-FACTOR; DRUG-NAIVE; PREVALENCE
AB The metabolic syndrome (MS) is highly prevalent among patients with schizophrenia (current estimates 35-40%), yet no data exist on the correlation of this diagnosis with illness severity, neurocognitive or quality of life measures in this population.
   Methods: Using baseline data from the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) Schizophrenia Trial, assignment of MS status was performed using an updated definition derived from the National Cholesterol Education Program (NCEP) criteria. Those with and without MS were compared on the basis of primary and secondary variables of interest from baseline data encompassing psychiatric, neurocognitive and quality of life measures.
   Results: Of 1460 subjects enrolled at baseline, MS status could be reliably assigned for 1231 subjects, with a prevalence of 35.8% using the NCEP derived criteria. After adjustment for age, gender, race, ethnicity and site variance, those with MS rated themselves significantly lower on physical health by SF-12 (p <.001), and scored higher on somatic preoccupation (PANSS item G 1) (p =.03). There were no significant differences between the two cohorts on measures of symptom severity, depression, quality of life, neurocognition, or self-rated mental health. Neither years of antipsychotic exposure nor alcohol usage were significant predictors of MS status when adjusted for age, gender, race, and ethnicity.
   Conclusions: The metabolic syndrome is highly prevalent in this large cohort of schizophrenia patients and is strongly associated with a poor self-rating of physical health and increased somatic preoccupation. These results underscore the need for mental health practitioners to take an active role in the health monitoring of patients with schizophrenia to minimize the impact of medical comorbidity on long-term mortality and on daily functioning. Outcomes data from CATIE will provide important information on the metabolic and clinical impact of antipsychotic treatment for those subjects with MS and other medical comorbidities. (c) 2005 Elsevier B.V. All rights reserved.
C1 VA San Diego Healthcare Syst, San Diego, CA USA.
   Univ Calif San Diego, Dept Psychiat, San Diego, CA 92103 USA.
   Univ Cincinnati, Cincinnati, OH 45267 USA.
   Duke Univ, Dept Psychiat & Behav Sci, Med Ctr, Durham, NC 27706 USA.
   John Umstead Hosp, Butner, NC 27509 USA.
   Harvard Univ, Dept Psychiat, Cambridge, MA 02138 USA.
   Lindemann Mental Hlth Ctr, Freedom Trail Clin, Boston, MA 02114 USA.
   Quintiles Inc, Biostat, Morrisville, NC 27560 USA.
   Suny Downstate Med Ctr, Brooklyn, NY 11203 USA.
   Univ Massachusetts, Sch Med, Worcester, MA 01605 USA.
   Univ N Carolina, Dept Psychiat, Chapel Hill, NC 27599 USA.
   Columbia Univ, Inst Psychiat, Dept Psychiat, New York, NY 10032 USA.
C3 US Department of Veterans Affairs; Veterans Health Administration (VHA);
   VA San Diego Healthcare System; University of California System;
   University of California San Diego; University System of Ohio;
   University of Cincinnati; Duke University; Harvard University; IQVIA;
   State University of New York (SUNY) System; SUNY Downstate Health
   Sciences University; University of Massachusetts System; University of
   Massachusetts Worcester; University of North Carolina; University of
   North Carolina Chapel Hill; Columbia University
RP San Diego VAMC, 3350 La Jolla Village Dr 116A, La Jolla, CA 92161 USA.
EM jmmeyer@ucsd.edu; NASRALHA@ucmail.uc.edu; jpmcevoy@duke.edu;
   goff@psych.mgh.harvard.edu; sonia.davis@quintiles.com;
   miranda.chakos@downstate.edu; Patel.jay@comcast.net;
   richard.keefe@duke.edu; scott_stroup@med.unc.edu; JL2616@columbia.edu
RI Lieberman, Jeffrey/AAY-8239-2020; Keefe, Richard/I-3411-2018; Stroup,
   T./AAB-7780-2019; Stroup, Thomas/F-9188-2014
OI Stroup, Thomas/0000-0002-3123-0672; Thomas, Sonia/0000-0003-1362-5627
FU NIMH NIH HHS [N01MH90001] Funding Source: Medline
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NR 59
TC 157
Z9 182
U1 1
U2 18
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0920-9964
EI 1573-2509
J9 SCHIZOPHR RES
JI Schizophr. Res.
PD DEC 1
PY 2005
VL 80
IS 1
BP 9
EP 18
DI 10.1016/j.schres.2005.07.015
PG 10
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 002KU
UT WOS:000234611100003
PM 16125372
DA 2025-06-11
ER

PT J
AU Oi, K
   Haas, S
AF Oi, Katsuya
   Haas, Steven
TI Cardiometabolic Risk and Cognitive Decline: The Role of Socioeconomic
   Status in Childhood and Adulthood
SO JOURNAL OF HEALTH AND SOCIAL BEHAVIOR
LA English
DT Article
DE cardiometabolic risk; cognitive aging; Health and Retirement Study; life
   course; socioeconomic status
ID LIFE-COURSE; CUMULATIVE ADVANTAGE; LONG ARM; HEALTH; RESERVE; STRESS;
   TRAJECTORIES; CONSEQUENCES; DISADVANTAGE; ENVIRONMENT
AB Socioeconomic conditions in childhood predict cognitive functioning in later life. It is unclear whether poor childhood socioeconomic status (SES) also predicts the acceleration of cognitive decline. One proposed pathway is via cardiometabolic risk, which has been linked to both childhood SES and earlier onset of cognitive impairment. Using data from the Health and Retirement Study, we examine the impact of childhood SES on cognitive trajectories over six years and test whether it operates through increased cardiometabolic risk and adult SES. We find that higher childhood SES leads to slower cognitive decline, partially due to lower levels of cardiometabolic risk. However, these pathways operate entirely through adult socioeconomic attainment. The results have important implications for future trends in cognitive population health within the context of growing social inequality and reduced social mobility.
C1 [Oi, Katsuya] No Arizona Univ, Sociol, Flagstaff, AZ 86011 USA.
   [Haas, Steven] Penn State Univ, Sociol & Demog, Tempe, AZ USA.
C3 Northern Arizona University
RP Oi, K (corresponding author), No Arizona Univ, SBS Castro, 308 5 E McConnell Dr, Flagstaff, AZ 86011 USA.
EM Katsuya.oi@nau.edu
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NR 66
TC 26
Z9 33
U1 0
U2 13
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0022-1465
EI 2150-6000
J9 J HEALTH SOC BEHAV
JI J. Health Soc. Behav.
PD SEP
PY 2019
VL 60
IS 3
BP 326
EP 343
DI 10.1177/0022146519867924
PG 18
WC Public, Environmental & Occupational Health; Psychology, Social; Social
   Sciences, Biomedical; Sociology
WE Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; Psychology; Biomedical
   Social Sciences; Sociology
GA IY6SL
UT WOS:000486526500004
PM 31526019
DA 2025-06-11
ER

PT J
AU Fortuño, A
   San José, G
   Moreno, MU
   Beloqui, O
   Díez, J
   Zalba, G
AF Fortuño, A
   San José, G
   Moreno, MU
   Beloqui, O
   Díez, J
   Zalba, G
TI Phagocytic NADPH oxidase overactivity underlies oxidative stress in
   metabolic syndrome
SO DIABETES
LA English
DT Article
ID DEPENDENT SUPEROXIDE-PRODUCTION; NAD(P)H OXIDASE;
   CARDIOVASCULAR-DISEASE; POSTPRANDIAL HYPERTRIGLYCERIDEMIA; ENDOTHELIAL
   DYSFUNCTION; INSULIN-RESISTANCE; SMOOTH-MUSCLE; GENERATION; EXPRESSION;
   MECHANISM
AB Oxidative stress plays a critical role in the pathogenesis of atherosclerosis in patients with metabolic syndrome. This study aimed to investigate whether a relationship exists between phagocytic NADPH oxidase activity and oxidative stress and atherosclerosis in metabolic syndrome patients. The study was performed in 56 metabolic syndrome patients (metabolic syndrome group), 99 patients with one or two cardiovascular risk factors (cardiovascular risk factor group), and 28 healthy subjects (control group). NADPH oxidase expression and activity was augmented (P < 0.05) in metabolic syndrome compared with cardiovascular risk factor and control groups. Insulin was enhanced. (P < 0.05) in metabolic syndrome patients compared with cardiovascular risk factor and control groups and correlated with NADPH oxidase activity in the overall population. Insulin stimulated NADPH oxidase activity; this effect was abolished by a specific protein kinase C inhibitor. Oxidized LDL and nitrotyrosine levels and carotid intima-media thickness were increased (P < 0.05) in the metabolic syndrome group compared with cardiovascular risk factor and control groups and correlated with NADPH oxidase activity in the overall population. These findings suggest that phagocytic NADPH oxidase overactivity is involved in oxidative stress and atherosclerosis in metabolic syndrome patients. Our findings also suggest that hyperinsulinemia may contribute to oxidative stress in metabolic syndrome patients through activation of NADPH oxidase.
C1 Univ Navarra, Ctr Appl Med Res, Div Cardiovasc Sci, Pamplona 31008, Spain.
   Univ Navarra, Dept Internal Med, Univ Clin, Pamplona 31008, Spain.
   Univ Navarra, Dept Cardiol & Cardiovasc Surg, Univ Clin, Pamplona 31008, Spain.
C3 University of Navarra; University of Navarra; University of Navarra
RP Univ Navarra, Ctr Appl Med Res, Div Cardiovasc Sci, Avda Pio XII 55, Pamplona 31008, Spain.
EM gzalba@unav.es
RI ZALBA, GUILLERMO/AAB-6231-2019; Diez Martinez, Domingo Francisco
   Javier/D-7014-2017; Fortuno, Ana/C-6921-2017; San Jose,
   Gorka/K-7501-2017; Moreno, MU/F-3278-2010
OI Diez Martinez, Domingo Francisco Javier/0000-0002-3414-6919; Beloqui
   Ruiz, Oscar/0000-0001-9542-3687; ZALBA, GUILLERMO/0000-0003-4616-1523;
   Fortuno, Ana/0000-0002-0796-4879; San Jose, Gorka/0000-0001-5878-1741;
   Moreno, MU/0000-0001-5441-9462
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NR 47
TC 113
Z9 126
U1 0
U2 5
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0012-1797
EI 1939-327X
J9 DIABETES
JI Diabetes
PD JAN
PY 2006
VL 55
IS 1
BP 209
EP 215
DI 10.2337/diabetes.55.1.209
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 998WB
UT WOS:000234349500026
PM 16380495
OA Bronze
DA 2025-06-11
ER

PT J
AU Lee, KU
AF Lee, KU
TI Oxidative stress markers in Korean subjects with insulin resistance
   syndrome
SO DIABETES RESEARCH AND CLINICAL PRACTICE
LA English
DT Article; Proceedings Paper
CT 2nd International Symposium on Free Radical and Vascular Biology of
   Diabetes
CY FEB, 2000
CL SEOUL, SOUTH KOREA
DE insulin resistance syndrome; oxidative stress; atherosclerosis
ID END-PRODUCTS; GLUCOSE; OBESITY; DISEASE; CELLS
AB Insulin resistance syndrome (IRS) is a cluster of prevalent conditions including glucose intolerance, hypertension and dyslipidemia. which commonly predispose to cardiovascular disease. However, the mechanism by which IRS is related with cardiovascular disease is not yet settled. Recently. it has been hypothesized that atherosclerosis is an inflammatory disease and that an increase in oxidative stress plays a key role in causing endothelial dysfunction associated with atherosclerosis. There has been, however. no study directly relating IRS with oxidative stress in human subjects. We measured various markers of oxidative stress among subjects who participated in a population-based epidemiological study performed in 1996. IRS was defined as non-diabetic subjects having more than two of three salient features of the syndrome (glucose intolerance, hypertriglyceridemia/low high density lipoprotein (HDL)-cholesterol and hypertension). The subjects with IRS (n = 70) showed higher plasma malondialdehyde (MDA; 2.10 +/- 1.43 vs. 1.63 +/- 1.21 mumol/ml, P = 0.009), homocysteine (16.32 +/- 8.34 vs. 13.06 +/- 6.49 mumol/l, P = 0.0022) and ceruloplasmin concentrations (29.80 +/- 5.28 vs. 27.39 +/- 5.10 mg/dl, P = 0.002) than control subjects (n = 196). Plasma MDA concentration was positively correlated with waist-to-hip ratio (r = 0.124, P = 0.044), and with plasma triglyceride (TG; r = 0.163, P = 0.008). ferritin (r = 0.200, P = 0.002) and homocysteine concentrations (r = 0.136, P = 0.032). These results suggest that increase in oxidative stress may contribute to the development of cardiovascular disease in IRS. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.
C1 Univ Ulsan, Coll Med, Dept Internal Med, Seoul 138040, South Korea.
C3 University of Ulsan
RP Lee, KU (corresponding author), Univ Ulsan, Coll Med, Dept Internal Med, 388-1 Songpagu Pungnapdong, Seoul 138040, South Korea.
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NR 14
TC 48
Z9 54
U1 0
U2 1
PU ELSEVIER SCI IRELAND LTD
PI CLARE
PA CUSTOMER RELATIONS MANAGER, BAY 15, SHANNON INDUSTRIAL ESTATE CO, CLARE,
   IRELAND
SN 0168-8227
J9 DIABETES RES CLIN PR
JI Diabetes Res. Clin. Pract.
PD DEC
PY 2001
VL 54
SU 2
BP S29
EP S33
DI 10.1016/S0168-8227(01)00332-1
PG 5
WC Endocrinology & Metabolism
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 512UK
UT WOS:000173341800004
PM 11733106
DA 2025-06-11
ER

PT J
AU Singareddy, R
   Ubde, TW
AF Singareddy, Ravi
   Ubde, Thomas W.
TI Nocturnal sleep panic and depression: Relationship to subjective sleep
   in panic disorder
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Nocturnal panic attacks; Sleep panic attacks; Depression; Sleep; Sleep
   duration; Insomnia; Hypersomnia; Metabolic Syndrome; Excessive sleep
ID BIPOLAR DISORDER; ATTACKS; INSOMNIA; ANXIETY; CONSEQUENCES; BEHAVIOR
AB Background: Patients with panic disorder (PD) often complain of sleep disturbances. PD patients have high co-morbid depression and almost 65-70% reports a history of nocturnal panic attacks. It is possible that both nocturnal-sleep panic attacks and depression contribute to sleep disturbances in PD patients. However, the individual and interactive effects of nocturnal-sleep panic attacks and lifetime depression on subjective sleep in PD are unknown.
   Methods: The National Institute of Mental Health Panic Disorder Questionnaire (NIMH-PQ) was administered to 773 individuals who met DSM-IV criteria for PD. All of these subjects completed queries related to nocturnal-sleep panic attacks, lifetime depression, difficulty sleeping, and sleep duration.
   Results: We examined difficulty in sleeping and sleep duration in four subgroups [PD without nocturnal panic attacks or lifetime depression (NP-D-), PD with nocturnal panic attacks (NP+D-), PD with lifetime depression (NP-D+), and PD with both nocturnal panic attacks and lifetime depression (NP+D+)]. Significantly greater proportions of NP+D+ subjects reported difficulty sleeping compared to other three subgroups. In addition, the NP+D+ patients reported significantly decreased subjective sleep durations compared to the other three subgroups. Using <= 5h as a criteria for severe sleep restriction, approximately 20% of the NP+D+ patients. compared to 9.2%, 9.6%, and 2.5% in the NP+D-, NP-D+, NP-D- subgroups, respectively, reported sleeping 5h or less. 8.2% of panic disorder patients reported excessive sleeping per sleeping period.
   Conclusions: A high percentage of panic disorder individuals report subjective sleep disturbances. Not surprisingly, an unusually high prevalence of patients with nocturnal panic attacks or depression have sleep problems and 92.3% of patients with both nocturnal panic attacks and depression report striking extremes in sleep duration or insomnia. Thus, nocturnal-sleep panic attacks and depression are independently as well as interactively associated with increased sleep disturbances in panic disorder. Although these findings are expected, they underscore the importance of assessing sleep functions, including over-sleeping, in panic disorder patients. (C) 2008 Published by Elsevier B.V.
C1 [Ubde, Thomas W.] Med Univ S Carolina, Inst Psychiat, Dept Psychiat & Behav Sci, Charleston, SC 29425 USA.
   [Singareddy, Ravi] Penn State Coll Med, Dept Psychiat H073, Hershey, PA 17033 USA.
C3 Medical University of South Carolina; Pennsylvania Commonwealth System
   of Higher Education (PCSHE); Pennsylvania State University; Penn State
   Health
RP Ubde, TW (corresponding author), Med Univ S Carolina, Inst Psychiat, Dept Psychiat & Behav Sci, 67 President St, Charleston, SC 29425 USA.
EM Uhde@musc.edu
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NR 30
TC 21
Z9 22
U1 0
U2 18
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD JAN
PY 2009
VL 112
IS 1-3
BP 262
EP 266
DI 10.1016/j.jad.2008.04.026
PG 5
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA 385UW
UT WOS:000261840100032
PM 18558437
DA 2025-06-11
ER

PT J
AU Thege, BK
   Emmanuel, T
   Hill, S
   Wells, L
AF Konkoly Thege, Barna
   Emmanuel, Talia
   Hill, Stephanie
   Wells, Laurie
TI Effectiveness of a complex psychosocial intervention to reduce metabolic
   syndrome in psychiatric outpatients with severe/persistent mental
   illness
SO CURRENT PSYCHOLOGY
LA English
DT Article
DE Metabolic syndrome; Abdominal circumference; Severe mental illness;
   Psychosocial intervention; Effectiveness
ID WEIGHT-GAIN; PSYCHOTIC DISORDERS; WAIST CIRCUMFERENCE; LIFE EXPECTANCY;
   SLEEP QUALITY; HEALTH LOCUS; RISK-FACTORS; BODY-IMAGE; SCHIZOPHRENIA;
   EXERCISE
AB The prevalence of metabolic syndrome among individuals with severe mental illness is considerably higher than in the general population, contributing to the 15-20-year shorter life expectancy of this client population. The aim of this pilot study was to evaluate the effectiveness of a novel, complex psychosocial program to reduce metabolic syndrome. Members of both the intervention (n = 78) and control (n = 31) group were psychiatric outpatients with severe/persistent mental illness struggling with one or more symptoms of metabolic syndrome. Beyond the default elements of similar programs such as diet and exercise, the intervention covered medication use, sleep hygiene, stress management, as well as addressing spiritual needs, mindfulness, addictions, and self-care. Assessment of metabolic indicators were completed at baseline, at the end of the 11-week intervention, and 6 months post-intervention. The trajectory of change over time was significantly more favorable in the treatment than in the control group in terms of waist circumference (p = 0.013, eta(2) = 0.093) and a positive trend emerged in relation to blood glucose level (p = 0.082, eta(2) = 0.057). However, no statistically reliable difference was observed between the intervention and the control group regarding the other outcome variables (body mass index, systolic and diastolic blood pressure, serum triglyceride level, serum HDL cholesterol level, overall metabolic syndrome severity). These findings suggest that to produce more robust benefits, psychosocial interventions targeting the metabolic health of individuals with complex mental health needs should be either longer in duration if resources permit or narrower in focus (diet and exercise mainly) if resources are scarce.
C1 [Konkoly Thege, Barna; Emmanuel, Talia; Wells, Laurie] Waypoint Ctr Mental Hlth Care, Waypoint Res Inst, 500 Church St, Penetanguishene, ON L9M 1G3, Canada.
   [Konkoly Thege, Barna; Hill, Stephanie; Wells, Laurie] Waypoint Ctr Mental Hlth Care, Outpatient Assessment & Treatment Serv, Midland, ON, Canada.
   [Konkoly Thege, Barna] Univ Toronto, Dept Psychiat, Toronto, ON, Canada.
C3 University of Toronto
RP Thege, BK (corresponding author), Waypoint Ctr Mental Hlth Care, Waypoint Res Inst, 500 Church St, Penetanguishene, ON L9M 1G3, Canada.; Thege, BK (corresponding author), Waypoint Ctr Mental Hlth Care, Outpatient Assessment & Treatment Serv, Midland, ON, Canada.; Thege, BK (corresponding author), Univ Toronto, Dept Psychiat, Toronto, ON, Canada.
EM bkonkoly-thege@waypointcentre.ca
RI ; Konkoly Thege, Barna/U-2253-2019
OI Emmanuel, Talia/0000-0001-5595-685X; Konkoly Thege,
   Barna/0000-0002-0861-8978
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NR 69
TC 1
Z9 1
U1 0
U2 11
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1046-1310
EI 1936-4733
J9 CURR PSYCHOL
JI Curr. Psychol.
PD APR
PY 2023
VL 42
IS 12
BP 9915
EP 9924
DI 10.1007/s12144-021-02269-3
EA SEP 2021
PG 10
WC Psychology, Multidisciplinary
WE Social Science Citation Index (SSCI)
SC Psychology
GA G9VF8
UT WOS:000695150000001
PM 34539154
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Zannas, AS
   Gordon, JL
   Hinderliter, AL
   Girdler, SS
   Rubinow, DR
AF Zannas, Anthony S.
   Gordon, Jennifer L.
   Hinderliter, Alan L.
   Girdler, Susan S.
   Rubinow, David R.
TI IL-6 Response to Psychosocial Stress Predicts 12-month Changes in
   Cardiometabolic Biomarkers in Perimenopausal Women
SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Article
DE cardiometabolic diseases; IL-6; inflammation; menopause; psychosocial
   stress
ID METABOLIC SYNDROME; ENDOTHELIAL FUNCTION; CARDIOVASCULAR-DISEASE;
   INSULIN-RESISTANCE; MENTAL STRESS; RISK-FACTORS; POSTMENOPAUSAL WOMEN;
   DEPRESSIVE SYMPTOMS; GENE-EXPRESSION; SOCIAL-STATUS
AB Objective: Cardiometabolic diseases are the number one cause of mortality, accounting for over one third of all deaths in the United States. Cardiometabolic risk further increases with psychosocial stress exposure and during menopausal transition in women. Because disease risk and stress burden are associated with aberrant immune signaling, we hypothesized that responses of interleukin-6 (IL-6) to psychosocial stress may predict longitudinal cardiometabolic outcomes in perimenopausal women.
   Methods: We conducted post hoc analyses in 151 perimenopausal or early postmenopausal women participants in a previously completed study. At study onset, participants underwent the Trier Social Stress Test (TSST), and plasma IL-6 was measured repeatedly before and during the 1 hour post-TSST. Subsequently, participants were randomly assigned to either hormonal treatment (HT) or placebo and followed for 12 months to determine longitudinal changes in cardiometabolic biomarkers.
   Results: Greater IL-6 reactivity to stress, measured with baseline-adjusted area under the curve, predicted 12-month decrease in flow-mediated dilatation of the brachial artery (P = 0.0005), a measure of endothelial-dependent vascular function, but not in endothelial-independent function measured with nitroglycerin-mediated dilatation (P = 0.17). Greater baseline IL-6 levels predicted 12-month increase in insulin resistance based on the homeostatic model assessment of insulin resistance score (P = 0.0045) and in the number of criteria met for metabolic syndrome (P = 0.0008). These predictions were not moderated by HT.
   Conclusions: Greater baseline IL-6 levels as well as its reactivity to stress may predict worsening in distinct cardiometabolic biomarkers as women transition to menopause. Interleukin-6 reactivity predicts decline in endothelial-dependent vascular function, whereas baseline IL-6 presages accumulation of metabolic risk.
C1 [Zannas, Anthony S.; Girdler, Susan S.; Rubinow, David R.] Univ N Carolina, Dept Psychiat, Chapel Hill, NC 27599 USA.
   [Zannas, Anthony S.] Univ N Carolina, Dept Genet, Chapel Hill, NC 27599 USA.
   [Zannas, Anthony S.] Duke Univ, Dept Psychiat & Behav Sci, Durham, NC 27710 USA.
   [Gordon, Jennifer L.] Univ Regina, Dept Psychol, Regina, SK S4S 0A2, Canada.
   [Hinderliter, Alan L.] Univ N Carolina, Dept Med, Chapel Hill, NC 27599 USA.
C3 University of North Carolina; University of North Carolina Chapel Hill;
   University of North Carolina; University of North Carolina Chapel Hill;
   Duke University; University of Regina; University of North Carolina;
   University of North Carolina Chapel Hill
RP Zannas, AS (corresponding author), Univ N Carolina, Dept Psychiat, Sch Med, 438 Taylor Hall,109 Mason Farm Rd, Chapel Hill, NC 27599 USA.
EM anthony_zannas@med.unc.edu
OI ZANNAS, ANTHONY/0000-0002-6897-9652
FU NIH [RO1-MH087619, R01-MH108690, UL1TR001111]; North Carolina
   Biotechnology Center [2013-IDG-1023]
FX This research was supported by NIH grants RO1-MH087619, R01-MH108690,
   and UL1TR001111, as well as North Carolina Biotechnology Center grant
   #2013-IDG-1023. Dr Gordon also receives salary support from the Canadian
   Institutes of Health Research as a Tier II Canada Research Chair in the
   Biopsychosocial Determinants of Women's Mental Health.
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NR 70
TC 6
Z9 6
U1 0
U2 2
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0021-972X
EI 1945-7197
J9 J CLIN ENDOCR METAB
JI J. Clin. Endocrinol. Metab.
PD OCT
PY 2020
VL 105
IS 10
AR dgaa476
DI 10.1210/clinem/dgaa476
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism
GA OK3DB
UT WOS:000584532100037
PM 32706883
OA Green Submitted, Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Mehranfar, S
   Jalilpiran, Y
   Ejtahed, HS
   Seif, E
   Shahrestanaki, E
   Mahdavi-Gorabi, A
   Esmaeili-Abdar, M
   Larijani, B
   Qorbani, M
AF Mehranfar, Sanaz
   Jalilpiran, Yahya
   Ejtahed, Hanieh-Sadat
   Seif, Ehsan
   Shahrestanaki, Ehsan
   Mahdavi-Gorabi, Armita
   Esmaeili-Abdar, Mohammad
   Larijani, Bagher
   Qorbani, Mostafa
TI Association of dietary phytochemical index with cardiometabolic risk
   factors A systematic review and meta-analysis on observational studies
SO INTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCH
LA English
DT Review
DE Cardio-metabolic risk factors; metabolic syndrome; phytochemical index;
   meta-analysis
ID WHOLE-GRAIN CONSUMPTION; TRADITIONAL MEDITERRANEAN DIET; 3-YEAR
   FOLLOW-UP; OXIDATIVE STRESS; NITRIC-OXIDE; CARDIOVASCULAR-DISEASE;
   INSULIN-RESISTANCE; ISCHEMIC-STROKE; POLYPHENOLS; FLAVONOIDS
AB Objective(s): Cardio-metabolic risk factors are becoming a global health concern. To address this problem, one of the proposed ways is to focus on phytochemical-rich foods consumption. Therefore, we aimed to summarize the results of observational studies (cohorts, case-control, and cross-sectional) that investigated the association between dietary phytochemical index (PI) as a new index for evaluating phytochemical-rich food intake and various risk factors of cardio-metabolic disorders. Methods: We conducted a comprehensive systematic review through PubMed, Scopus, and Web of Science databases. The literature search was performed up to August 2021 with no publication year restriction on observational studies investigating the association between PI and cardiometabolic risk factors on adults and children. A random-effect meta-analysis was used. Results: Overall, 16 articles (cross-sectional, case-control, cohort) were eligible for this systematic review and 8 studies with 99771 participants were included in the meta-analysis. Random effect meta-analysis showed that adherence to higher dietary PI decrease the odds of abdominal obesity (OR: 0.73, 95% CI: 0.58, 0.88, I-2: 84.90), generalized obesity (OR: 0.84, 95% CI: 0.69, 0.98, I-2: 68.10), hypertriglyceridemia (OR: 0.81, 95% CI: 0.73, 0.89, I-2: 0.00), hypertension (OR: 0.86, 95% CI: 0.73, 0.99, I-2: 7.02), and MetS (OR: 0.79, 95% CI: 0.69, 0.88, I-2: 84.90). However, results considering the associations between dietary PI with glycemic indices, and low high-density lipoprotein (HDL) were not significant (p<0.05). Conclusion: Evidence showed adverse associations between dietary PI and some cardio metabolicrisk factors such as obesity, hypertriglyceridemia, hypertension and metabolic syndrome.
C1 [Mehranfar, Sanaz] Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Community Nutr, Tehran, Iran.
   [Jalilpiran, Yahya] Shiraz Univ Med Sci, Sch Nutr & Food Sci, Student Res Comm, Shiraz, Iran.
   [Jalilpiran, Yahya] Univ Tehran Med Sci, Students Sci Res Ctr, Tehran, Iran.
   [Ejtahed, Hanieh-Sadat] Univ Tehran Med Sci, Obes & Eating Habits Res Ctr, Endocrinol & Metab Clin Sci Inst, Tehran, Iran.
   [Ejtahed, Hanieh-Sadat; Larijani, Bagher] Univ Tehran Med Sci, Endocrinol & Metab Res Ctr, Endocrinol & Metab Clin Sci Inst, North Kargar Ave, Tehran 1411413137, Iran.
   [Seif, Ehsan; Shahrestanaki, Ehsan; Qorbani, Mostafa] Alborz Univ Med Sci, Noncommunicable Dis Res Ctr, Karaj, Iran.
   [Shahrestanaki, Ehsan] Iran Univ Med Sci, Sch Publ Hlth, Dept Epidemiol, Tehran, Iran.
   [Mahdavi-Gorabi, Armita] Alborz Univ Med Sci, Probiot Res Ctr, Karaj, Iran.
   [Esmaeili-Abdar, Mohammad] Alborz Univ Med Sci, Social Determinants Hlth Res Ctr, Karaj, Iran.
   [Qorbani, Mostafa] Univ Tehran Med Sci, Chron Dis Res Ctr, Endocrinol & Metab Populat Sci Inst, Tehran, Iran.
C3 Tehran University of Medical Sciences; Shiraz University of Medical
   Science; Tehran University of Medical Sciences; Tehran University of
   Medical Sciences; Tehran University of Medical Sciences; Alborz
   University of Medical Sciences; Iran University of Medical Sciences;
   Alborz University of Medical Sciences; Alborz University of Medical
   Sciences; Tehran University of Medical Sciences
RP Ejtahed, HS (corresponding author), Univ Tehran Med Sci, Endocrinol & Metab Res Ctr, Endocrinol & Metab Clin Sci Inst, North Kargar Ave, Tehran 1411413137, Iran.
EM haniejtahed@yahoo.com
RI ejtahed, hanieh/AAH-4921-2021; Qorbani, Mostafa/M-8171-2017; larijani,
   Bagher/ABE-3315-2020; Mehranfar, Sanaz/GRJ-0656-2022
OI Ejtahed, Hanieh-Sadat/0000-0002-6395-4915; Larijani,
   Bagher/0000-0001-5386-7597
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NR 85
TC 8
Z9 8
U1 0
U2 14
PU IMR PRESS
PI ROBINSON
PA 112 ROBINSON RD, ROBINSON, SINGAPORE
SN 0300-9831
EI 1664-2821
J9 INT J VITAM NUTR RES
JI Int. J. Vitam. Nutr. Res.
PD DEC
PY 2023
VL 93
IS 6
BP 559
EP 576
DI 10.1024/0300-9831/a000763
EA AUG 2022
PG 18
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA CF9C7
UT WOS:000843213700001
PM 35997240
DA 2025-06-11
ER

PT J
AU Torres-Zegarra, C
   Sundararajan, D
   Benson, J
   Seagle, H
   Witten, M
   Walders-Abramson, N
   Simon, SL
   Huguelet, P
   Nokoff, NJ
   Cree-Green, M
AF Torres-Zegarra, C.
   Sundararajan, D.
   Benson, J.
   Seagle, H.
   Witten, M.
   Walders-Abramson, N.
   Simon, S. L.
   Huguelet, P.
   Nokoff, N. J.
   Cree-Green, M.
TI Care for Adolescents With Polycystic Ovary Syndrome: Development and
   Prescribing Patterns of a Multidisciplinary Clinic
SO JOURNAL OF PEDIATRIC AND ADOLESCENT GYNECOLOGY
LA English
DT Article
DE Multidisciplinary clinic; Polycystic ovary syndrome; Adolescent;
   Dermatology; Mental health; Sleep health; Metabolic syndrome
ID QUALITY-OF-LIFE; SELF-ESTEEM; DEPRESSION; OBESITY; MODELS; WOMEN
AB Study Objective: Based on updated guidelines and expressed patient needs, we created a multidisciplinary clinic including endocrinology, gynecology/adolescent medicine, dermatology, psychology, and nutrition to provide comprehensive care to adolescent girls with polycystic ovary syndrome (PCOS). We describe the patient population presenting to this clinic, and prescribing patterns when a multidisciplinary approach is used.
   Design: Retrospective chart review.
   Setting: Tertiary care hospital.
   Participants: Female patients, aged 11-24 years, presenting for initial assessment in a multidisciplinary PCOS clinic.
   Interventions: None.
   Main Outcome Measures: Medical history, physical examination findings, laboratory measurements and prescribed therapies.
   Results: A total of 92 patients seen from 2014 to 2018 are described (age 15.9 years, range 11-24 years, body mass index 35.6 kg/m(2), range 19.9-53.5). Metabolic syndrome features were common: 26% had a prediabetes hemoglobin A1c (>5.6%), 83% had a high-density lipoprotein (HDL) <50 mg/dL, 40% had a systolic blood pressure >120 mm Hg, and 43% had an alanine aminotransferase level of >30 U/L. Dermatologic findings included acne 93%, hirsutism 38%, acanthosis nigricans 85%, hidradenitis suppurativa 16%, and androgenic alopecia 2%. Of the patients, 33% had a diagnosis of depression or anxiety, 16% of patients had a diagnosis of obstructive sleep apnea, and an additional 59% had symptoms warranting a sleep study The most commonly prescribed medications were topical acne preparations (62%), followed by estrogen-containing hormonal therapy (56%) and metformin (40%).
   Conclusion: In adolescents with PCOS and obesity, metabolic, dermatologic, and psychologic co-morbidities are common. The use of a multidisciplinary clinic model including dermatology in addition to endocrinology, gynecology, psychology, and lifestyle experts provides care for most aspects of PCOS.
C1 [Torres-Zegarra, C.] Univ Colorado, Div Dermatol, Dept Surg, Anschutz Med Campus, Aurora, CO USA.
   [Sundararajan, D.; Benson, J.; Walders-Abramson, N.; Nokoff, N. J.; Cree-Green, M.] Univ Colorado, Div Endocrinol, Dept Pediat, Anschutz Med Campus, Aurora, CO USA.
   [Seagle, H.; Witten, M.] Childrens Hosp Colorado, Dept Nutr, Aurora, CO USA.
   [Simon, S. L.] Univ Colorado, Div Pulm & Sleep Med, Dept Pediat, Anschutz Med Campus, Aurora, CO USA.
   [Huguelet, P.] Univ Colorado, Sect Pediat & Adolescent Gynecol, Dept Obstet & Gynecol, Anschutz Med Campus, Aurora, CO USA.
   [Nokoff, N. J.; Cree-Green, M.] Univ Colorado, Ctr Womens Hlth Res, Anschutz Med Campus, Aurora, CO USA.
C3 University of Colorado System; University of Colorado Anschutz Medical
   Campus; University of Colorado System; University of Colorado Anschutz
   Medical Campus; Children's Hospital Colorado; University of Colorado
   System; University of Colorado Anschutz Medical Campus; University of
   Colorado System; University of Colorado Anschutz Medical Campus;
   University of Colorado System; University of Colorado Anschutz Medical
   Campus
RP Cree-Green, M (corresponding author), Box 265 13123 E 16th Ave, Aurora, CO 80045 USA.
EM melanie.green@childrenscolorado.org
RI Cree, Melanie/S-9494-2019; Nokoff, Natalie/AAN-5342-2021; Simon,
   Stacey/G-9882-2016
OI Simon, Stacey/0000-0003-4755-8151; Sundararajan,
   Divya/0000-0002-7500-7608; Benson, Jessie/0000-0002-5103-3959; Nokoff,
   Natalie/0000-0002-9190-3947
FU NIDDK [T32 DK063687]; BIRCWH [K12HD057022, K23DK107871, K23DK117021];
   Doris Duke Foundation [2015212]; Children's Hospital Colorado
FX Funding was provided by the following: NIDDK T32 DK063687, BIRCWH
   K12HD057022, K23DK107871 Doris Duke Foundation 2015212 and Children's
   Hos-pital Colorado (to MCG); NIDDK T32 DK063687, BIRCWH K12HD057022,
   Doris Duke Foundation 2015212 (to NJN); and BIRCWH K12HD057022,
   K23DK117021 (to SLS).
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NR 38
TC 20
Z9 20
U1 2
U2 19
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1083-3188
EI 1873-4332
J9 J PEDIATR ADOL GYNEC
JI J. Pediatr Adolesc. Gynecol.
PD OCT
PY 2021
VL 34
IS 5
BP 617
EP 625
DI 10.1016/j.jpag.2021.02.002
EA AUG 2021
PG 9
WC Obstetrics & Gynecology; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology; Pediatrics
GA UJ8PH
UT WOS:000691540600007
PM 33794340
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Sharma, I
   Marwale, AV
   Sidana, R
   Gupta, ID
AF Sharma, Indira
   Marwale, Arun V.
   Sidana, Roop
   Gupta, Ishwar D.
TI Lifestyle modification for mental health and well-being
SO INDIAN JOURNAL OF PSYCHIATRY
LA English
DT Review
DE Diabetes; hypertension; life style; modification; obesity; well-being
ID METABOLIC SYNDROME; PHYSICAL-ACTIVITY; ASIAN INDIANS; EXERCISE;
   PREVALENCE
AB Background:Unhealthy life-style leads to mental ill-health and poor quality of life and is the major determinant of a wide range of lifestyle disorders. The aim was to 1) review the work relating to life style modification for promoting mental health and 2) Present recommendations on life-style modification for mental health and wellbeing.Material and Methods:The work on life style changes for promotion of mental health was retrieved from the scientific literature and critically reviewed.Conclusions:Recommendations on 'Life-style modification for mental health and wellbeing' are presented. 20 specific components of healthy life style included are: Routine, time management, prayer, basic activities, reading newspaper, study/work, exercise, recreation/ relaxation/ talent promotion, education, cognitive activities, social networking, guidelines for behavior, peer group, social group, marriage/family, life skills, physical health, health education, mobile use, and digital media. The lifestyle modification package is comprehensive and geared to promote mental health and well-being.
C1 [Sharma, Indira] Banaras Hindu Univ, Inst Med Sci, Psychiat NAMS, Varanasi, Uttar Pradesh, India.
   [Sharma, Indira] Banaras Hindu Univ, Inst Med Sci, Dept Psychiat, Varanasi, Uttar Pradesh, India.
   [Marwale, Arun V.] Mahatma Gandhi Mem Med Coll, Dept Psychiat, Aurangabad, Maharashtra, India.
   [Sidana, Roop] Tekchand Sidana Mem Mental Psychiat Hosp & Deaddic, Sri Ganganagar, Rajasthan, India.
   [Gupta, Ishwar D.] Sawai Man Singh Med Coll, Dept Psychiat, Jaipur, Rajasthan, India.
   [Sharma, Indira] N8-180-118 Rajendra Vihar, Varanasi 221005, Uttar Pradesh, India.
C3 Banaras Hindu University (BHU); Banaras Hindu University (BHU); SMS
   Medical College & Hospital
RP Sharma, I (corresponding author), N8-180-118 Rajendra Vihar, Varanasi 221005, Uttar Pradesh, India.
EM indira_06@rediffmail.com
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NR 112
TC 2
Z9 2
U1 6
U2 18
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, Maharashtra, INDIA
SN 0019-5545
EI 1998-3794
J9 INDIAN J PSYCHIAT
JI Indian J. Psychiatry
PD MAR
PY 2024
VL 66
IS 3
BP 219
EP 234
DI 10.4103/indianjpsychiatry.indianjpsychiatry_39_24
PG 16
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA LI5H7
UT WOS:001186169500013
PM 39100126
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Chang, AK
   Fritschi, C
   Kim, MJ
AF Chang, Ae Kyung
   Fritschi, Cynthia
   Kim, Mi Ja
TI Sedentary Behavior, Physical Activity, and Psychological Health of
   Korean Older Adults with Hypertension Effect of an Empowerment
   Intervention
SO RESEARCH IN GERONTOLOGICAL NURSING
LA English
DT Article
ID TELEVISION VIEWING TIME; DEPRESSIVE SYMPTOMS; METABOLIC SYNDROME;
   PERCEIVED HEALTH; SELF-EFFICACY; RISK; EXERCISE; WOMEN; MEN; INACTIVITY
AB The aim of this study was to determine the effect of an 8-week empowerment intervention on sedentary behavior, physical activity, and psychological health in Korean older adults with hypertension. Using a quasi-experimental design, older adults participated in either an experimental group (n = 27) or control group (n = 21). The experimental group received an empowerment intervention including lifestyle modification education, group discussion, and exercise training for 8 weeks, and the control group received standard hypertension education. After 8 weeks, participants in the experimental group had significantly decreased sedentary behavior, increased physical activity, increased self-efficacy for physical activity, and increased perceived health (p < 0.05). However, no significant group difference was found for depression. Findings from this study suggest that empowerment interventions may be more effective than standard education in decreasing sedentary behavior and increasing physical activity, self-efficacy for physical activity, and perceived health in Korean older adults with hypertension.
C1 [Chang, Ae Kyung] Chungbuk Natl Univ, Dept Nursing Sci, Chongju 361763, South Korea.
   [Fritschi, Cynthia; Kim, Mi Ja] Univ Illinois, Coll Nursing, Dept Biobehav Hlth Sci, Chicago, IL USA.
   [Fritschi, Cynthia; Kim, Mi Ja] Univ Illinois, Coll Nursing, Off Global Hlth Leadership, Chicago, IL USA.
   [Chang, Ae Kyung] Univ Illinois, Coll Nursing, Chicago, IL USA.
C3 Chungbuk National University; University of Illinois System; University
   of Illinois Chicago; University of Illinois Chicago Hospital; University
   of Illinois System; University of Illinois Chicago; University of
   Illinois Chicago Hospital; University of Illinois System; University of
   Illinois Chicago; University of Illinois Chicago Hospital
RP Chang, AK (corresponding author), Chungbuk Natl Univ, Dept Nursing Sci, 52 Naesudong Ro, Chongju 361763, South Korea.
EM annie908@daum.net
OI Fritschi, Cynthia/0000-0001-5447-8315
FU Global Korean Nursing Foundation
FX The authors have disclosed no potential conflicts of interest, financial
   or otherwise. The project was supported in part by the Global Korean
   Nursing Foundation. The authors thank Kevin Grandfield for editorial
   assistance.
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NR 44
TC 30
Z9 39
U1 2
U2 48
PU SLACK INC
PI THOROFARE
PA 6900 GROVE RD, THOROFARE, NJ 08086 USA
SN 1940-4921
EI 1938-2464
J9 RES GERONTOL NURS
JI Res. Gerontol. Nurs.
PD APR
PY 2013
VL 6
IS 2
BP 81
EP 88
DI 10.3928/19404921-20121219-01
PG 8
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA 173UA
UT WOS:000321105000002
PM 23293986
DA 2025-06-11
ER

PT J
AU Sinclair, AJ
   Abdelhafiz, AH
AF Sinclair, Alan J.
   Abdelhafiz, Ahmed H.
TI Cardiometabolic disease in the older person: prediction and prevention
   for the generalist physician
SO CARDIOVASCULAR ENDOCRINOLOGY & METABOLISM
LA English
DT Review
DE cardiometabolic disease; cardiovascular; diabetes; older people; risk
ID CARDIOVASCULAR-DISEASE; SARCOPENIC-OBESITY; METABOLIC SYNDROME;
   BLOOD-PRESSURE; RISK-FACTORS; FRAILTY; IMPACT; ADULTS; COMPLICATIONS;
   DISORDERS
AB Ageing is associated with chronic inflammation and oxidative stress that increase the risk of cardiovascular disease. Frailty and sarcopenia, which are associated with increased visceral obesity and muscle mass loss, are now emerging as new potential risk factors for cardiovascular disease. Increased muscle visceral fat leads to increased secretion of harmful proinflammatory adipokines and reduced muscle mass leads to reduced secretion of the protective myokines creating an abnormal cardiometabolic state increasing the risk of cardiovascular disease. This review: (1) explore traditional and newly emerging cardiometabolic risk factors in older people; (2) investigate methods of prediction and prevention of cardiovascular disease in those with diabetes; and (3) concludes that the development of a subspeciality of Cardiometabolic Medicine should be considered. Copyright (c) 2020 Wolters Kluwer Health, Inc. All rights reserved.
C1 [Sinclair, Alan J.] Diabet Frail Ltd, Fdn Diabet Res Older People, Droitwich Spa WR9 0QH, England.
   [Sinclair, Alan J.] Kings Coll London, London, England.
   [Abdelhafiz, Ahmed H.] Rotherham Gen Hosp, Dept Geriatr Med, Rotherham, S Yorkshire, England.
C3 University of London; King's College London
RP Sinclair, AJ (corresponding author), Diabet Frail Ltd, Fdn Diabet Res Older People, Droitwich Spa WR9 0QH, England.
EM Sinclair.5@btinternet.com
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NR 44
TC 24
Z9 23
U1 1
U2 8
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 2574-0954
J9 CARDIOVASC ENDOCR ME
JI Cardiovasc. Endocrinol. Metab.
PD SEP
PY 2020
VL 9
IS 3
BP 90
EP 95
DI 10.1097/XCE.0000000000000193
PG 6
WC Cardiac & Cardiovascular Systems
WE Emerging Sources Citation Index (ESCI)
SC Cardiovascular System & Cardiology
GA NH0NL
UT WOS:000564376200005
PM 32803140
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Quansah, DY
   Gilbert, L
   Kosinski, C
   Le Dizes, O
   Horsch, A
   Benhalima, K
   Cosson, E
   Puder, JJ
AF Quansah, Dan Yedu
   Gilbert, Leah
   Kosinski, Christophe
   Le Dizes, Olivier
   Horsch, Antje
   Benhalima, Katrien
   Cosson, Emmanuel
   Puder, Jardena J.
TI Cardio-Metabolic and Mental Health Outcomes Before and During the
   COVID-19 Pandemic in a Cohort of Women With Gestational Diabetes
   Mellitus in Switzerland
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Article
DE COVID-19; pandemic; gestational diabetes; depression; postpartum;
   cardio-metabolic; obstetric; neonatal
ID PREGNANCY OUTCOMES; IMPACT
AB BackgroundThe COVID-19 pandemic has been associated with worsened metabolic and mental health in the general and perinatal population. The postpartum is a critical moment regarding these outcomes particularly in women with gestational diabetes mellitus (GDM). We investigated the cardio-metabolic and mental health outcomes before and during the pandemic in this population. MethodsThis cohort study included 418 women with GDM, recruited during two distinct periods. This included 180 women exposed to the pandemic (E+) and recruited between May 2020-April 2021 and 238 women who were not exposed to the pandemic during their postpartum period (attended a year before=non-exposed (E-)) and recruited between January-December 2019. Among the E+, a nested-subcohort of 120 women were exposed both during pregnancy and postpartum. During the pandemic, we adopted a hybrid follow-up of women that consisted of in-person consultations, regular contact via phone calls (35%), sent recorded exercise guide to patients to follow at home and linked to our website. We specifically focused on maintaining motivation and keeping a strong focus on healthy lifestyle behaviors. Obstetric, neonatal, cardio-metabolic and mental health outcomes were assessed during pregnancy and postpartum. ResultsThe pandemic was not associated with worsened weight, weight retention, glucose tolerance, metabolic syndrome, well-being or depression in the postpartum with the exception of a minimally increased HbA1c, diastolic blood pressure and lower emotional eating scores in E+ women (all p <= 0.046). In the nested subcohort, E+ women had a slightly increased HbA1c at the first GDM visit and a higher need for glucose-lowering medication (both p <= 0.014), but HbA1c at the end of pregnancy and other cardio-metabolic, mental health, obstetric and neonatal outcomes during pregnancy were similar. ConclusionsThe pandemic was not associated with any clinically relevant worsening of cardio-metabolic, mental health, obstetrical and neonatal outcomes in our GDM cohort. This was possibly due to a continued hybrid follow-up, and the partial lockdown in Switzerland.
C1 [Quansah, Dan Yedu; Gilbert, Leah; Puder, Jardena J.] Lausanne Univ Hosp, Dept Woman Mother Child, Obstet Serv, Lausanne, Switzerland.
   [Kosinski, Christophe; Le Dizes, Olivier] Lausanne Univ Hosp, Dept Med, Serv Endocrinol Diabet & Metab, Lausanne, Switzerland.
   [Horsch, Antje] Univ Lausanne, Inst Higher Educ & Res Healthcare IUFRS, Lausanne, Switzerland.
   [Horsch, Antje] Lausanne Univ Hosp, Dept Woman Mother Child, Neonatol Serv, Lausanne, Switzerland.
   [Benhalima, Katrien] Katholieke Univ Leuven, Dept Endocrinol, UZ Gasthuisberg, Leuven, Belgium.
   [Cosson, Emmanuel] Paris 13 Univ, Bobigny, France.
   [Cosson, Emmanuel] Univ Paris 13, Sorbonne Paris Cite, UMR,Inserm,U1153, Inra,Cnam,U1125, Bobigny, France.
C3 University of Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV);
   University of Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV);
   University of Lausanne; University of Lausanne; Centre Hospitalier
   Universitaire Vaudois (CHUV); KU Leuven; University Hospital Leuven;
   Institut National de la Sante et de la Recherche Medicale (Inserm);
   Universite Paris 13; Universite Paris Cite; heSam Universite;
   Conservatoire National Arts & Metiers (CNAM); INRAE
RP Quansah, DY (corresponding author), Lausanne Univ Hosp, Dept Woman Mother Child, Obstet Serv, Lausanne, Switzerland.
EM dan.quansah@chuv.ch
RI Kosinski, Christophe/ABB-6319-2021; Cosson, Emmanuel/F-3051-2017;
   Gilbert, Leah/AAX-7055-2020; Horsch, Antje/AEQ-2835-2022; Benhalima,
   Katrien/K-5800-2017; Quansah, Dan/B-8499-2018
OI Puder, Jardena/0000-0002-0460-7614; Horsch, Antje/0000-0002-9950-9661;
   Gilbert, Leah/0000-0002-0580-0141; Kosinski,
   Christophe/0000-0002-7544-498X; Benhalima, Katrien/0000-0002-3325-0263;
   Quansah, Dan/0000-0002-3091-9400
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NR 46
TC 1
Z9 2
U1 2
U2 9
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD JUL 22
PY 2022
VL 13
AR 948716
DI 10.3389/fendo.2022.948716
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 3Q5RV
UT WOS:000838289000001
PM 35957818
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Mityukova, TA
   Chudilovskaya, EN
   Basalai, AA
AF Mityukova, T. A.
   Chudilovskaya, E. N.
   Basalai, A. A.
TI Reactivity of the Thyroid System to Short-Term Stress in Wistar Rats
   with Visceral Obesity and Restricted Social Activity
SO JOURNAL OF EVOLUTIONARY BIOCHEMISTRY AND PHYSIOLOGY
LA English
DT Article
DE rat; high-calorie diet; social isolation; stress; thyroid system;
   cortisol
ID ANXIETY DISORDER; DEPRESSION; MODELS; MICE
AB The obesity problem requires a study of its pathophysiological consequences affecting hormonal regulation and organism's reactivity to extreme exposures. The study was aimed first to examine the effect of a high-calorie diet and social isolation, as well as their combination for 4 months, on the development of obesity, its metabolic and behavioral sequelae, features of the thyroid status, while at the second stage, to assess the reaction of hormonal indices of the thyroid status to short-term stress in rats. The experiments were carried out on male Wistar rats and at the first stage focused on the effects of a high-calorie diet and social isolation, as well as their combinations for 4 months. At the end of the experiment, behavioral reactions, metabolic syndrome indices, thyroid status, and cortisol levels were evaluated. At the second stage, the animals were exposed to short-term acute stress, and the shifts in the hormonal indices were recorded one hour later versus the initial background. A high-calorie diet led to the development of metabolic syndrome, signs of depression, increased thyroid-stimulating hormone (TSH), thyroxine and triiodothyronine serum levels, as well as iodothyronine deiodinase type 1 (D1) activity, in the rat liver. At the same time, there was a decrease in thyroperoxidase activity and an increase in thyroid levels of triglycerides and malondialdehyde. The physiological response to stress in the control rat group included an increase in cortisol and TSH serum levels, however, against the background of a high-calorie diet, no cortisol release into the bloodstream was recorded. Social isolation did not alter normal reactivity of the adrenal cortex, but reduced TSH release in response to acute stress, since the initial level of this hormone was slightly elevated against the background of chronic social isolation stress. Thus, excessive nutrition and the deficit of social activities in male Wistar rats led to significant changes in the organism's reactivity to acute stress.
C1 [Mityukova, T. A.; Chudilovskaya, E. N.; Basalai, A. A.] Natl Acad Sci Belarus, Inst Physiol, Minsk, BELARUS.
C3 National Academy of Sciences of Belarus (NASB); Institute of Physiology
   of the National Academy of Sciences of Belarus
RP Mityukova, TA (corresponding author), Natl Acad Sci Belarus, Inst Physiol, Minsk, BELARUS.
EM mityukovat@gmail.com; e.chudilovskaya@gmail.com
RI Basalai, Anastasia/MBG-9503-2025; Mityukova, Tatyana/NHP-0129-2025
OI Chudilovskaya, Ekaterina/0009-0001-5563-2473; Mityukova,
   Tatyana/0009-0009-7503-6634; Basalai, Anastasia/0000-0002-1878-9623
FU Institute of Physiology of the National Academy of Sciences of Belarus
   within the SSRP "Fundamental and applied sciences for medicine",
   research theme "To investigate neuroendocrine mechanisms of rat
   propensity to obesity" [20200320]
FX The work was supported by the governmental budget funding to the
   Institute of Physiology of the National Academy of Sciences of Belarus
   within the SSRP "Fundamental and applied sciences for medicine",
   research theme "To investigate neuroendocrine mechanisms of rat
   propensity to obesity" (reg. no. 20200320 of 16.03.2020).
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NR 22
TC 2
Z9 2
U1 0
U2 0
PU PLEIADES PUBLISHING INC
PI NEW YORK
PA PLEIADES HOUSE, 7 W 54 ST, NEW YORK,  NY, UNITED STATES
SN 0022-0930
EI 1608-3202
J9 J EVOL BIOCHEM PHYS+
JI J. Evol. Biochem. Physiol.
PD MAR
PY 2022
VL 58
IS 2
BP 465
EP 475
DI 10.1134/S0022093022020156
PG 11
WC Biochemistry & Molecular Biology; Evolutionary Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Evolutionary Biology; Physiology
GA 1H4WP
UT WOS:000796544500015
PM 35599640
OA Green Published
DA 2025-06-11
ER

PT J
AU Brinkmann, B
   Payne, CF
   Kohler, I
   Harling, G
   Davies, J
   Witham, M
   Siedner, MJ
   Sie, A
   Bountogo, M
   Ouermi, L
   Coulibaly, B
   Bärnighausen, T
AF Brinkmann, Ben
   Payne, Collin F.
   Kohler, Iliana
   Harling, Guy
   Davies, Justine
   Witham, Miles
   Siedner, Mark J.
   Sie, Ali
   Bountogo, Mamadou
   Ouermi, Lucienne
   Coulibaly, Boubacar
   Baernighausen, Till
TI Depressive symptoms and cardiovascular disease: a population-based study
   of older adults in rural Burkina Faso
SO BMJ OPEN
LA English
DT Article
DE depression &amp; mood disorders; hypertension; stroke medicine; public
   health; epidemiology; mental health
ID CORONARY-HEART-DISEASE; METABOLIC SYNDROME; RISK; METAANALYSIS;
   ASSOCIATION; ANXIETY; HYPERTENSION; PREVALENCE; MANAGEMENT; DISORDERS
AB Objectives To contribute to the current understanding of depressive disorders in sub-Saharan African (SSA) countries by examining the association of depressive symptoms with cardiovascular and cardiometabolic conditions in a population-based study of middle-aged and older adults in rural Burkina Faso. Setting This study was conducted in the Nouna Health and Demographic Surveillance System in north-western Burkina Faso, in a mixed rural and small-town environment. The data were obtained between May and July 2018. Participants Consenting adults over 40 years of age (n=3026). Primary and secondary outcome measures Depressive symptoms were assessed using the Patient Health Questionnaire depression module (PHQ-9). Chronic cardiometabolic conditions were assessed via a lipid panel and glycated haemoglobin measures from serum, alongside anthropometry and blood pressure measurements and a self-reported questionnaire. Multivariable linear regression was used to test the relationship between depressive symptoms and cardiovascular/cardiometabolic conditions after controlling for sociodemographic factors. Results Depressive symptoms were not associated with the metabolic syndrome (standardised beta coefficient=0.00 (95% CI -0.04 to 0.03)), hypertension (beta=0.01 (95% CI -0.02 to 0.05)), diabetes mellitus (beta=0.00 (95% CI -0.04 to 0.04)) and past diagnosis of elevated blood pressure or blood sugar. Prior stroke diagnosis (beta=0.04 (95% CI 0.01 to 0.07)) or heart disease (beta=0.08 (95% CI 0.05 to 0.11)) was positively associated with the standardised PHQ-9 score as were self-reported stroke symptoms. Conclusion Objectively measured cardiometabolic conditions had no significant association with depressive symptoms in an older, poor, rural SSA population, in contrast to observations in high income countries. However, consequences of cardiovascular disease such as stroke and heart attack were associated with depressive symptoms in older adults in Burkina Faso.
C1 [Brinkmann, Ben; Baernighausen, Till] Heidelberg Univ, Heidelberg Inst Global Hlth, Heidelberg, Germany.
   [Payne, Collin F.] Australian Natl Univ, Sch Demog, Canberra, ACT, Australia.
   [Kohler, Iliana] Univ Penn, Populat Studies Ctr PSC, Philadelphia, PA 19104 USA.
   [Kohler, Iliana] Univ Penn, Dept Sociol, Philadelphia, PA 19104 USA.
   [Harling, Guy] UCL, Inst Global Hlth, London, England.
   [Harling, Guy] Harvard TH Chan Sch Publ Hlth, Harvard Ctr Populat & Dev Studies, Cambridge, MA USA.
   [Harling, Guy] Univ Witwatersrand, MRC Wits Rural Publ Hlth & Hlth Transit Res Unit, Johannesburg, South Africa.
   [Harling, Guy; Baernighausen, Till] Africa Hlth Res Inst, Kwa Zulu, South Africa.
   [Davies, Justine] Univ Birmingham, Inst Appl Hlth Res, Birmingham, W Midlands, England.
   [Witham, Miles] Newcastle Univ, NIHR Newcastle BioMed Res Ctr, AGE Res Grp, Newcastle Upon Tyne, Tyne & Wear, England.
   [Witham, Miles] Newcastle Tyne Hosp NHS Fdn Trust, Newcastle Upon Tyne, Tyne & Wear, England.
   [Siedner, Mark J.] Harvard Med Sch, Massachusetts Gen Hosp, Dept Med, Boston, MA 02115 USA.
   [Sie, Ali; Bountogo, Mamadou; Ouermi, Lucienne; Coulibaly, Boubacar] Ctr Rech Sante Nouna, Nouna, Boucle Du Mouho, Burkina Faso.
C3 Ruprecht Karls University Heidelberg; Australian National University;
   University of Pennsylvania; University of Pennsylvania; University of
   London; University College London; Harvard University; Harvard T.H. Chan
   School of Public Health; University of Witwatersrand; Africa Health
   Research Institute; University of Birmingham; Newcastle University - UK;
   Newcastle Upon Tyne Hospitals NHS Foundation Trust; Harvard University;
   Harvard Medical School; Harvard University Medical Affiliates;
   Massachusetts General Hospital
RP Brinkmann, B (corresponding author), Heidelberg Univ, Heidelberg Inst Global Hlth, Heidelberg, Germany.
EM ben.brinkmann@stud.uni-heidelberg.de
RI Barnighausen, Till/Y-2388-2019
OI Siedner, Mark/0000-0003-3506-842X; Payne, Collin/0000-0002-3061-1609;
   Davies, Justine/0000-0001-6834-1838; Brinkmann, Ben/0000-0002-1726-5430;
   Bountogo, Mamadou/0000-0001-5010-1617; Harling, Guy/0000-0001-6604-491X;
   Witham, Miles/0000-0002-1967-0990
FU Alexander von Humboldt Foundation through an Alexander von Humboldt
   Professor award - German Federal Ministry of Education and Research;
   National Institute for Health Research Newcastle Biomedical Research
   Centre; Wellcome Trust [210479/Z/18/Z]; Royal Society [210479/Z/18/Z];
   ANU Futures Scheme; Wellcome Trust [210479/Z/18/Z] Funding Source:
   Wellcome Trust
FX Funding for the CRSN Heidelberg Aging Study (CHAS) was provided by the
   Alexander von Humboldt Foundation through an Alexander von Humboldt
   Professor award to TB, which is funded by the German Federal Ministry of
   Education and Research. MW acknowledges support from National Institute
   for Health Research Newcastle Biomedical Research Centre. GH is
   supported by a fellowship from the Wellcome Trust and Royal Society
   (210479/Z/18/Z). CFP acknowledges support from the ANU Futures Scheme.
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NR 62
TC 11
Z9 12
U1 0
U2 4
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2044-6055
J9 BMJ OPEN
JI BMJ Open
PY 2020
VL 10
IS 12
AR e038199
DI 10.1136/bmjopen-2020-038199
PG 10
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA PL0RN
UT WOS:000602840300012
PM 33371016
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Zimmerman, FH
AF Zimmerman, Franklin H.
TI Cardiovascular Disease and Risk Factors in Law Enforcement Personnel: A
   Comprehensive Review
SO CARDIOLOGY IN REVIEW
LA English
DT Review
DE law enforcement; police; cardiovascular disease; risk factors; public
   safety
ID CORONARY-HEART-DISEASE; SUDDEN STRENUOUS EXERCISE; ALL-CAUSE MORTALITY;
   POLICE OFFICERS; PHYSICAL-ACTIVITY; METABOLIC SYNDROME; BLOOD-PRESSURE;
   SHIFT WORK; MYOCARDIAL-INFARCTION; OCCUPATIONAL INJURIES
AB Law enforcement is a high-stress occupation that is prone to increasing the prevalence and incidence of cardiovascular disease. Epidemiological studies suggest that police officers and related public safety personnel have an increased risk of cardiovascular morbidity and mortality. Currently employed police personnel have a high prevalence of traditional risk factors, including hypertension, hyperlipidemia, metabolic syndrome, cigarette smoking, and a sedentary lifestyle. Obesity may be more common in police officers compared with civilians, whereas diabetes is present less frequently. Law enforcement personnel are also exposed to occupation-specific risk factors that include sudden physical exertion, acute and chronic psychological stress, shift work, and noise. Workplace programs to promote the health and fitness of police officers are commonly lacking, but can be an effective means for reducing cardiovascular risk. Physicians should be familiar with the essential job tasks required for police officers to determine whether the individual is fit for duty. Governmental agencies have established strategic goals to reduce cardiovascular complications and improve the health and wellness of public safety personnel.
C1 [Zimmerman, Franklin H.] Phelps Mem Hosp Ctr, Div Cardiol, Dept Med, Sleepy Hollow, NY USA.
   [Zimmerman, Franklin H.] Columbia Univ Coll Phys & Surg, Dept Med, New York, NY 10032 USA.
C3 Northwell Health; Columbia University
RP Zimmerman, FH (corresponding author), 465 N State Rd, Briarcliff Manor, NY 10510 USA.
EM FhzMD@aol.com
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NR 166
TC 154
Z9 182
U1 1
U2 38
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1061-5377
EI 1538-4683
J9 CARDIOL REV
JI Cardiol. Rev.
PD JUL-AUG
PY 2012
VL 20
IS 4
BP 159
EP 166
DI 10.1097/CRD.0b013e318248d631
PG 8
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Cardiovascular System & Cardiology
GA 956GY
UT WOS:000305079300001
PM 22314143
DA 2025-06-11
ER

PT J
AU Jormfeldt, H
   Doyle, L
   Ellilä, H
   Lahti, M
   Higgins, A
   Keogh, B
   Meade, O
   Stickley, T
   Sitvast, J
   Skärsäter, I
   Kilkku, N
AF Jormfeldt, Henrika
   Doyle, Louise
   Ellila, Heikki
   Lahti, Mari
   Higgins, Agnes
   Keogh, Brian
   Meade, Oonagh
   Stickley, Theodore
   Sitvast, Jan
   Skarsater, Ingela
   Kilkku, Nina
TI Master's level mental health nursing competencies, a prerequisite for
   equal health among service users in mental health care
SO INTERNATIONAL JOURNAL OF QUALITATIVE STUDIES ON HEALTH AND WELL-BEING
LA English
DT Article
DE Holistic health; "master's level mental health nursing competencies";
   mental health care; physical health
ID SELF-REPORTED HEALTH; PHYSICAL HEALTH; METABOLIC SYNDROME; PEOPLE;
   SCHIZOPHRENIA; BARRIERS; ILLNESS; LIFE; PROMOTION; NURSES
AB Purpose: This discussion paper aims to explore the need of a clarified definition of master's level mental health nursing competencies in terms of knowledge, skills and attitudes in a European context. Mental health service users have, in spite of their right to equal overall health, higher rates of physical illness and are more likely to experience premature death than the general population. Implementation of a holistic concept of health comprising mental, physical and social aspects of health in mental health services has previously proved to be challenging. Methods: Master's level mental health nursing competencies in recent literature are discussed and illuminated in terms of knowledge, skills and attitudes in order to enable the promotion of equal overall health among service users in mental health services. Results: The discussion show contents, values and utility of master's level mental health nursing competencies in mental health services and contribute to reduced role ambiguity by distinguishing master's level responsibilities from undergraduate nursing tasks and obligations of other professionals in mental health care. Conclusion: This discussion paper shapes implications for developments in master's level mental health nursing education curricula.
C1 [Jormfeldt, Henrika] Halmstad Univ, Sch Hlth & Wellfare, Master Level Mental Hlth Nursing Educ, Halmstad, Sweden.
   [Skarsater, Ingela] Halmstad Univ, Sch Hlth & Wellfare, Hlth & Lifestyle, Halmstad, Sweden.
   [Doyle, Louise] Trinity Coll Dublin, Sch Nursing & Midwifery, Dublin, Ireland.
   [Higgins, Agnes; Keogh, Brian] Trinity Coll Dublin, Sch Nursing & Midwifery, Mental Hlth Nursing, Dublin, Ireland.
   [Ellila, Heikki] Turku Univ Appl Sci, Hlth & Well Being, Nursing, Turku, Finland.
   [Lahti, Mari] Turku Univ Appl Sci, Hlth & Well Being, Turku, Finland.
   [Meade, Oonagh] Univ Nottingham, Fac Med & Hlth Sci, Sch Hlth Sci, Nottingham, England.
   [Stickley, Theodore] Univ Nottingham, Fac Med & Hlth Sci, Sch Hlth Sci, Mental Hlth, Inst Mental Hlth Bldg,Triumph Rd,Innovat Pk, Nottingham, England.
   [Sitvast, Jan] Univ Appl Sci HU, Adv Nursing Practice, Utrecht, Netherlands.
   [Kilkku, Nina] Tampere Univ Appl Sci, Kuntokatu 3, Tampere 33520, Finland.
C3 Halmstad University; Halmstad University; Trinity College Dublin;
   Trinity College Dublin; Turku University of Applied Sciences; Turku
   University of Applied Sciences; University of Nottingham; University of
   Nottingham; Tampere University; Tampere University of Applied Sciences
   TAMK
RP Jormfeldt, H (corresponding author), Halmstad Univ, Sch Hlth & Welf, Box 823, SE-30118 Halmstad, Sweden.
EM henrika.jormfeldt@hh.se
RI Lahti, Mari/AAG-4366-2020; Kilkku, Nina/AID-8718-2022
OI Doyle, Louise/0000-0002-0153-8326; Meade, Oonagh/0000-0001-8160-2318;
   Lahti, Mari/0000-0002-3403-5418; Kilkku, Nina/0000-0003-1207-0682
FU European Commission [European Commission] [2013-3403]
FX This work was supported by the European Commission [European Commission
   (2013-3403)/Life-long learning programme].
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   World Health Organization, 1991, IMPL FIELD MENT HLTH
NR 65
TC 8
Z9 9
U1 0
U2 12
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1748-2623
EI 1748-2631
J9 INT J QUAL STUD HEAL
JI Int. J. Qual. Stud. Health Well-Being
PY 2018
VL 13
SU 1
AR 1502013
DI 10.1080/17482631.2018.1502013
PG 9
WC Public, Environmental & Occupational Health; Nursing; Social Sciences,
   Biomedical
WE Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; Nursing; Biomedical Social
   Sciences
GA HM8KJ
UT WOS:000459729600003
PM 30067476
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Sabiston, C
   Castonguay, A
   Barnett, T
   O'Loughlin, J
   Lambert, M
AF Sabiston, C.
   Castonguay, A.
   Barnett, T.
   O'Loughlin, J.
   Lambert, M.
TI Body image and C-reactive protein in adolescents
SO INTERNATIONAL JOURNAL OF OBESITY
LA English
DT Article
DE body dissatisfaction; cardiometabolic risk; body mass index; mental
   health
ID DIETARY RESTRAINT; CHILDREN; STRESS; RISK; INFLAMMATION; RELIABILITY;
   SAMPLE
AB Background: The association between inflammation and obesity is well documented; however, there is little evidence linking physiological markers of inflammation and psychosocial factors such as body image. This study examined the relation between body image and C-reactive protein (CRP).
   Methods: Data were available for 1503 adolescents aged 13 and 16 years in a province-wide survey of a representative sample of youth in Quebec, Canada. Participants completed questionnaires assessing body image indicators of social pressures to lose weight and personal body shape discrepancies, provided a fasting blood sample for CRP, and had height and weight measured.
   Results: In separate multivariable logistic regression models for girls and boys, body shape discrepancy was positively associated with CRP (boys: OR 2.6, 95% CI 1.4- 4.8; girls: OR 2.2, 95% CI 1.2- 4.3) independent of body mass index, puberty status and socio-demographic variables.
   Conclusions: Adverse biological markers of cardiometabolic risk and negative body image are associated in adolescence. These findings suggest that, in addition to the well-known psychological problems, negative body image perceptions may also threaten adolescent's physical health. International Journal of Obesity (2009) 33, 597-600; doi:10.1038/ijo.2009.28; published online 10 February 2009
C1 [Sabiston, C.; Castonguay, A.] McGill Univ, Dept Kinesiol & Phys Educ, Montreal, PQ H2W 1S4, Canada.
   [Barnett, T.; Lambert, M.] Ctr Hosp Ste Justine, Ctr Rech, Montreal, PQ, Canada.
   [Barnett, T.; O'Loughlin, J.] Univ Montreal, Dept Social & Prevent Med, Montreal, PQ, Canada.
   [O'Loughlin, J.] Ctr Hosp Univ Montreal, Montreal, PQ, Canada.
   [Lambert, M.] Ste Justine & Univ Montreal, Dept Pediat, Montreal, PQ, Canada.
C3 McGill University; Universite de Montreal; Universite de Montreal
RP Sabiston, C (corresponding author), McGill Univ, Dept Kinesiol & Phys Educ, 475 Pine Ave W, Montreal, PQ H2W 1S4, Canada.
EM catherine.sabiston@mcgill.ca
RI Sabiston, Catherine/AEY-6307-2022
CR [Anonymous], EXACTING BEAUTY THEO
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NR 20
TC 15
Z9 17
U1 0
U2 5
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0307-0565
J9 INT J OBESITY
JI Int. J. Obes.
PD MAY
PY 2009
VL 33
IS 5
BP 597
EP 600
DI 10.1038/ijo.2009.28
PG 4
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 443DF
UT WOS:000265889700012
PM 19204727
DA 2025-06-11
ER

PT J
AU Sabban, EL
   Alaluf, LG
   Serova, LI
AF Sabban, Esther L.
   Alaluf, Lishay G.
   Serova, Lidia I.
TI Potential of neuropeptide Y for preventing or treating post-traumatic
   stress disorder
SO NEUROPEPTIDES
LA English
DT Article
DE Intranasal; Resilience; PTSD; Depression; Single prolonged stress
ID CORTICOTROPIN-RELEASING-FACTOR; HYPOTHALAMIC PARAVENTRICULAR NUCLEUS;
   LOCUS-CERULEUS NEURONS; MESSENGER-RNA; ARCUATE NUCLEUS; DIFFERENTIAL
   REGULATION; METABOLIC SYNDROME; RECEPTOR SUBTYPES; GENETIC-VARIATION;
   RESTRAINT STRESS
AB There is extensive evidence that NPY in the brain can modulate the responses to stress and play a critical role in resistance to, or recovery from, harmful effects of stress. Development of PTSD and comorbid depression following exposure to traumatic stress are associated with low NPY. This review discusses putative mechanisms for NPY's anti-stress actions. Recent preclinical data indicating potential for intranasal delivery of NPY to brain as a promising non-invasive strategy to prevent a variety of neuroendocrine, molecular and behavioral impairments in PTSD model are summarized. (C) 2015 Elsevier Ltd. All rights reserved.
C1 [Sabban, Esther L.; Alaluf, Lishay G.; Serova, Lidia I.] New York Med Coll, Dept Biochem & Mol Biol, Basic Sci Bldg, Valhalla, NY 10595 USA.
C3 New York Medical College
RP Sabban, EL (corresponding author), New York Med Coll, Dept Biochem & Mol Biol, Basic Sci Bldg, Valhalla, NY 10595 USA.
EM sabban@nymc.edu
FU U.S. Army, Department of Defense Medical Research and Development
   Program [DM102281]; CDMRP [545735, DM102281] Funding Source: Federal
   RePORTER
FX This work was supported by grant DM102281 from the U.S. Army, Department
   of Defense Medical Research and Development Program.
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NR 90
TC 66
Z9 73
U1 0
U2 13
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0143-4179
EI 1532-2785
J9 NEUROPEPTIDES
JI Neuropeptides
PD APR
PY 2016
VL 56
BP 19
EP 24
DI 10.1016/j.npep.2015.11.004
PG 6
WC Endocrinology & Metabolism; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology
GA DJ6YW
UT WOS:000374360100003
PM 26617395
OA Bronze
DA 2025-06-11
ER

PT J
AU Miner, MM
   Heidelbaugh, J
   Paulos, M
   Seftel, AD
   Jameson, J
   Kaplan, SA
AF Miner, Martin M.
   Heidelbaugh, Joel
   Paulos, Mark
   Seftel, Allen D.
   Jameson, Jason
   Kaplan, Steven A.
TI The Intersection of Medicine and Urology An Emerging Paradigm of Sexual
   Function, Cardiometabolic Risk, Bone Health, and Men's Health Centers
SO MEDICAL CLINICS OF NORTH AMERICA
LA English
DT Article
DE Medicine and urology; Sexual function; Cardiometabolic risk; Bone
   health; Men's health centers
ID CORONARY-ARTERY CALCIUM; ERECTILE-DYSFUNCTION; TESTOSTERONE THERAPY;
   CARDIOVASCULAR RISK; HEART-DISEASE; HIP FRACTURE; DOUBLE-BLIND; OLDER
   MEN; ASYMPTOMATIC PATIENTS; AMERICAN-COLLEGE
AB Men's mental health and how they think about their health are critical to the future of men's health. Poor health choice patterns are established under age 50 years, when men are twice more likely to die than women. As the future of medicine focuses on quality and value, a better understanding of the social determinants of men's health will identify areas for improvement. The presentation of a man with a sexual health complaint to a clinician's office presents an opportunity for more complete evaluation. The future of men's health will be well served by integrated men's health centers that focus on the entire man.
C1 [Miner, Martin M.] Brown Univ, Warren Alpert Med Sch, Miriam Hosp, Dept Family Med & Urol,Mens Hlth Ctr, 164 Summitt Ave, Providence, RI 02906 USA.
   [Heidelbaugh, Joel] Univ Michigan, Med Sch, Dept Family Med, Ann Arbor, MI USA.
   [Heidelbaugh, Joel] Univ Michigan, Med Sch, Dept Urol, Ann Arbor, MI USA.
   [Paulos, Mark] Brown Univ, Miriam Hosp, Warren Alpert Sch Med, Dept Internal Med,Mens Hlth Ctr, Providence, RI USA.
   [Paulos, Mark] Brown Univ, Miriam Hosp, Warren Alpert Sch Med, Dept Urol,Mens Hlth Ctr, Providence, RI USA.
   [Seftel, Allen D.] Rowan Univ, Cooper Med Sch, Cooper Univ Hosp, Div Urol, Camden, NJ USA.
   [Jameson, Jason] Mayo Clin, Div Urol, Scottsdale, AZ USA.
   [Kaplan, Steven A.] Icahn Sch Med Mt Sinai, Mt Sinai Hlth Syst, Benign Urol Dis & Mens Hlth Program, New York, NY 10029 USA.
C3 Lifespan Health Rhode Island; Miriam Hospital; Brown University;
   University of Michigan System; University of Michigan; University of
   Michigan System; University of Michigan; Brown University; Lifespan
   Health Rhode Island; Miriam Hospital; Lifespan Health Rhode Island;
   Miriam Hospital; Brown University; Cooper University Hospital; Rowan
   University; Cooper Medical School of Rowan University; Mayo Clinic; Mayo
   Clinic Phoenix; Icahn School of Medicine at Mount Sinai
RP Miner, MM (corresponding author), Brown Univ, Warren Alpert Med Sch, Miriam Hosp, Dept Family Med & Urol,Mens Hlth Ctr, 164 Summitt Ave, Providence, RI 02906 USA.
EM Martin_Miner@Brown.edu
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NR 97
TC 8
Z9 9
U1 0
U2 1
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0025-7125
EI 1557-9859
J9 MED CLIN N AM
JI Med. Clin. N. Am.
PD MAR
PY 2018
VL 102
IS 2
BP 399
EP +
DI 10.1016/j.mcna.2017.11.002
PG 18
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA FX5SQ
UT WOS:000426140300017
PM 29406067
DA 2025-06-11
ER

PT J
AU Butnoriene, J
   Bunevicius, A
   Saudargiene, A
   Nemeroff, CB
   Norkus, A
   Ciceniene, V
   Bunevicius, R
AF Butnoriene, Jurate
   Bunevicius, Adomas
   Saudargiene, Ausra
   Nemeroff, Charles B.
   Norkus, Antanas
   Ciceniene, Vile
   Bunevicius, Robertas
TI Metabolic syndrome, major depression, generalized anxiety disorder, and
   ten-year all-cause and cardiovascular mortality in middle aged and
   elderly patients
SO INTERNATIONAL JOURNAL OF CARDIOLOGY
LA English
DT Article
DE Metabolic syndrome; Cardiovascular mortality; Depression; Anxiety
ID CHOLESTEROL EDUCATION-PROGRAM; 3RD NATIONAL-HEALTH; ARTERIAL STIFFNESS;
   EXCESS MORTALITY; MENTAL-DISORDERS; OLDER SUBJECTS; PREVALENCE; DISEASE;
   WOMEN; METAANALYSIS
AB Background: Studies investigating specifically whether metabolic syndrome (MetS) and common psychiatric disorders are independently associated with mortality are lacking. In a middle-aged general population, we investigated the association of the MetS, current major depressive episode (MDE), lifetime MDE, and generalized anxiety disorder (GAD) with ten-year all-cause and cardiovascular disease mortality.
   Methods: From February 2003 until January 2004, 1115 individuals aged 45 years and older were randomly selected from a primary care practice and prospectively evaluated for: (1) MetS (The World Health Organization [WHO], National Cholesterol Education Program/Adult Treatment Panel III and International Diabetes Federation [IDF] definitions); (2) current MDE and GAD, and lifetime MDE (Mini International Neuropsychiatric Interview); and (3) conventional cardiovascular risk factors. Follow-up continued through January, 2013.
   Results: During the 9.32 +/- 0.47 years of follow-up, there were 248 deaths, of which 148 deaths were attributed to cardiovascular causes. In women, WHO-MetS and IDF-MetS were associated with greater all-cause (HR-values range from 1.77 to 1.91; p-values <= 0.012) and cardiovascular (HR-values range from 1.83 to 2.77; p-values <= 0.013) mortality independent of cardiovascular risk factors and MDE/GAD. Current GAD predicted greater cardiovascular mortality (HR-values range from 1.86 to 1.99; p-values <= 0.025) independently from MetS and cardiovascular risk factors. In men, the MetS and MDE/GAD were not associated with mortality.
   Conclusions: In middle aged women, the MetS and GAD predicted greater 10-year cardiovascular mortality independently from each other; 10-year all-cause mortality was independently predicted by the MetS. MetS and GAD should be considered important and independent mortality risk factors in women. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
C1 [Butnoriene, Jurate; Norkus, Antanas] Lithuanian Univ Hlth Sci, Inst Endocrinol, LT-50009 Kaunas, Lithuania.
   [Bunevicius, Adomas] Lithuanian Univ Hlth Sci, Inst Neurosci, LT-50009 Kaunas, Lithuania.
   [Saudargiene, Ausra] Vytautas Magnus Univ, Dept Informat, Kaunas, Lithuania.
   [Nemeroff, Charles B.] Univ Miami, Miller Sch Med, Dept Psychiat & Behav Sci, Miami, FL 33136 USA.
   [Ciceniene, Vile] Inst Hyg, Vilnius, Lithuania.
   [Bunevicius, Robertas] Lithuanian Univ Hlth Sci, Behav Med Inst, Palanga, Lithuania.
C3 Lithuanian University of Health Sciences; Lithuanian University of
   Health Sciences; Vytautas Magnus University; University of Miami;
   Lithuanian University of Health Sciences
RP Bunevicius, A (corresponding author), Lithuanian Univ Hlth Sci, Inst Neurosci, Eiveniu 2, LT-50009 Kaunas, Lithuania.
EM a.bunevicius@yahoo.com
RI Nemeroff, Charles/AEU-9195-2022; Bunevicius, Adomas/I-3394-2019
OI Bunevicius, Adomas/0000-0003-0446-6898; Nemeroff,
   Charles/0000-0001-7867-1160
FU Research Council of Lithuania [LIG-03/2011]
FX Financial support for the study was provided by the Research Council of
   Lithuania (grant number: LIG-03/2011).
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NR 55
TC 49
Z9 53
U1 0
U2 28
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0167-5273
EI 1874-1754
J9 INT J CARDIOL
JI Int. J. Cardiol.
PD JUL 1
PY 2015
VL 190
BP 360
EP 366
DI 10.1016/j.ijcard.2015.04.122
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Cardiovascular System & Cardiology
GA CI9TI
UT WOS:000355112400099
PM 25939128
DA 2025-06-11
ER

PT J
AU Sun, P
   Huang, YY
   Yu, H
   Wu, XH
   Chen, J
   Fang, YR
   Zhang, XY
AF Sun, Ping
   Huang, Yingying
   Yu, Hui
   Wu, Xiaohui
   Chen, Jun
   Fang, Yiru
   Zhang, Xiangyang
TI Gender differences in clinical characteristics and influencing factors
   of suicide attempts in first-episode and drug-naïve major depressive
   disorder patients with comorbid metabolic syndrome
SO BMC PSYCHIATRY
LA English
DT Article
DE Major depressive disorder; Metabolic syndrome; Suicide attempts; Gender
   difference
ID MENTAL-DISORDERS; SEX-DIFFERENCES; RATING-SCALE; RISK-FACTORS;
   PREVALENCE; SYMPTOMS; METAANALYSIS; ASSOCIATION; ANXIETY; ADULTS
AB BackgroundsPatients with major depressive disorder (MDD) have a high rate of metabolic syndrome (MetS), which could worsen disease progression. One of the most serious progressions in MDD is suicide attempts (SAs). Previous studies have found gender differences in MetS and SAs among MDD patients respectively. Therefore, we aimed to explore gender differences of SAs in first-episode and drug-na & iuml;ve (FEDN) MDD patients with comorbid MetS.Methods1718 outpatients with FEDN MDD were recruited. Depression, anxiety and psychotic symptoms were evaluated using the Hamilton Depression Scale (HAMD), Hamilton Anxiety Scale (HAMA) and Positive and Negative Syndrome Scale (PANSS) positive subscale, respectively. Blood sugar, blood fat, blood pressure and body mass index (BMI) were measured to evaluate MetS.Results34.4% patients with FEDN MDD were diagnosed as MetS and those subjects with or without MetS differed in the distribution of SAs and gender. In MetS subgroup, 29.5% and 29.7% of male and female subjects had SAs respectively, without significant differences. However, compared with non-suicide attempters, suicide attempters had higher level of blood pressure in female subjects, while there are no differences in any clinical variables in male subjects. Additionally, the influencing factors for SAs differed by gender. The HAMA scores and BMI were variables associated with SAs in male patients while HAMA scores, marital status and systolic blood pressure (SBP) were associated with SAs in female patients. Furthermore, the receiver operating characteristics (ROC) curves, demonstrating the combination all influencing factors by gender, showed good performance and model accuracy.ConclusionsIn FEDN MDD patients with comorbid MetS, there were no gender differences in SAs. However, clinical characteristics and influencing factors of SAs differed in different gender groups.
C1 [Sun, Ping; Yu, Hui] Qingdao Mental Hlth Ctr, Qingdao 266034, Shandong, Peoples R China.
   [Huang, Yingying] Nanjing Univ, Nanjing Brain Hosp, Clin Teaching Hosp, Med Sch, Nanjing 210093, Peoples R China.
   [Wu, Xiaohui; Chen, Jun; Fang, Yiru] Shanghai Jiao Tong Univ, Clin Res Ctr, Shanghai Mental Hlth Ctr, Div Mood Disorders,Sch Med, Shanghai 200030, Peoples R China.
   [Fang, Yiru] Shanghai Jiao Tong Univ, Ruijin Hosp, Dept Psychiat & Affect Disorders Ctr, Sch Med, 197 Rui Jin Er Rd, Shanghai 200025, Peoples R China.
   [Fang, Yiru] Shanghai Key Lab Psychot disorders, Shanghai 201108, Peoples R China.
   [Zhang, Xiangyang] Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, 16 Lincui Rd, Beijing 100101, Peoples R China.
   [Zhang, Xiangyang] Univ Chinese Acad Sci, Dept Psychol, Beijing 100083, Peoples R China.
C3 Nanjing University; Shanghai Jiao Tong University; Shanghai Jiao Tong
   University; Chinese Academy of Sciences; Institute of Psychology, CAS;
   Chinese Academy of Sciences; University of Chinese Academy of Sciences,
   CAS
RP Fang, YR (corresponding author), Shanghai Jiao Tong Univ, Clin Res Ctr, Shanghai Mental Hlth Ctr, Div Mood Disorders,Sch Med, Shanghai 200030, Peoples R China.; Fang, YR (corresponding author), Shanghai Jiao Tong Univ, Ruijin Hosp, Dept Psychiat & Affect Disorders Ctr, Sch Med, 197 Rui Jin Er Rd, Shanghai 200025, Peoples R China.; Fang, YR (corresponding author), Shanghai Key Lab Psychot disorders, Shanghai 201108, Peoples R China.; Zhang, XY (corresponding author), Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, 16 Lincui Rd, Beijing 100101, Peoples R China.; Zhang, XY (corresponding author), Univ Chinese Acad Sci, Dept Psychol, Beijing 100083, Peoples R China.
EM yirufang@aliyun.com; zhangxy@psych.ac.cn
RI WU, XIAOHUI/NHO-8747-2025; Chen, Jun/AAJ-1972-2020; Zhang,
   Chaoyang/AAN-2433-2021
FU National Key R&D Program of China [2016YFC1307100]; National Natural
   Science Foundation of China [81930033]; Clinical Research Plan of
   Shanghai Hospital Development Center [16CR2027B]; Science and Technology
   Program of Guangdong [2018B030334001]
FX This work was supported by the National Key R&D Program of China
   (2016YFC1307100); the National Natural Science Foundation of China
   (81930033); the Clinical Research Plan of Shanghai Hospital Development
   Center (16CR2027B) and the Science and Technology Program of Guangdong
   (2018B030334001).
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NR 62
TC 0
Z9 0
U1 2
U2 2
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-244X
J9 BMC PSYCHIATRY
JI BMC Psychiatry
PD NOV 11
PY 2024
VL 24
IS 1
AR 789
DI 10.1186/s12888-024-06256-3
PG 13
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychiatry
GA L7Z3U
UT WOS:001352865100003
PM 39529096
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Joseph, JJ
   Golden, SH
AF Joseph, Joshua J.
   Golden, Sherita H.
TI Cortisol dysregulation: the bidirectional link between stress,
   depression, and type 2 diabetes mellitus
SO ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
LA English
DT Review
DE cortisol; stress; depression; diabetes; hypothalamic-pituitary-adrenal
   axis
ID PITUITARY-ADRENAL AXIS; DIURNAL SALIVARY CORTISOL; AWAKENING RESPONSE;
   ALLOSTATIC LOAD; INSULIN-RESISTANCE; METABOLIC SYNDROME; MAJOR
   DEPRESSION; GLUCOCORTICOID-RESISTANCE; PSYCHOLOGICAL DISTRESS;
   PSYCHOSOCIAL FACTORS
AB Controversy exists over the role of stress and depression in the pathophysiology of type 2 diabetesmellitus. Depression has been shown to increase the risk for progressive insulin resistance and incident type 2 diabetesmellitus in multiple studies, whereas the association of stress with diabetes is less clear, owing to differences in study designs and in forms and ascertainment of stress. The biological systems involved in adaptation that mediate the link between stress and physiological functions include the hypothalamic-pituitary-adrenal (HPA) axis and the autonomic nervous and immune systems. The HPA axis is a tightly regulated system that represents one of the body's mechanisms for responding to acute and chronic stress. Depression is associated with cross-sectional and longitudinal alterations in the diurnal cortisol curve, including a blunted cortisol awakening response and flattening of the diurnal cortisol curve. Flattening of the diurnal cortisol curve is also associated with insulin resistance and type 2 diabetes mellitus. In this article, we review and summarize the evidence supporting HPA axis dysregulation as an important biological link between stress, depression, and type 2 diabetes mellitus.
C1 [Joseph, Joshua J.; Golden, Sherita H.] Johns Hopkins Univ, Sch Med, Dept Med, Div Endocrinol Diabet & Med, 1830 E Monument St,Suite 333, Baltimore, MD 21287 USA.
C3 Johns Hopkins University
RP Golden, SH (corresponding author), Johns Hopkins Univ, Sch Med, Dept Med, Div Endocrinol Diabet & Med, 1830 E Monument St,Suite 333, Baltimore, MD 21287 USA.
EM sahill@jhmi.edu
RI Joseph, Joshua/NDR-8695-2025
OI Joseph, Joshua/0000-0001-9169-8261
FU National Heart, Lung, and Blood Institute [NO1-HC-95159, NO1-HC-95165,
   NO1-HC-95169]; National Institute of Diabetes and Digestive and Kidney
   Diseases [T32 DK062707];  [RO1 HL10161-01A1];  [R21 DA024273]
FX The authors thank the other investigators, staff, and participants of
   MESA for their valuable contributions. A full list of participating MESA
   investigators and institutions can be found at
   http://www.mesa-nhlbi.org. MESA was supported by Contracts NO1-HC-95159
   through NO1-HC-95165 and NO1-HC-95169 from the National Heart, Lung, and
   Blood Institute. MESA Stress was supported by RO1 HL10161-01A1 and R21
   DA024273 (principal investigator: Ana Diez Roux). Joshua J. Joseph was
   supported by an institutional training grant from the National Institute
   of Diabetes and Digestive and Kidney Diseases (T32 DK062707).
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NR 100
TC 371
Z9 411
U1 13
U2 178
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0077-8923
EI 1749-6632
J9 ANN NY ACAD SCI
JI Ann. N.Y. Acad. Sci.
PD MAR
PY 2017
VL 1391
IS 1
SI SI
BP 20
EP 34
DI 10.1111/nyas.13217
PG 15
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Science & Technology - Other Topics
GA ER4XT
UT WOS:000398806300002
PM 27750377
OA Green Accepted, Bronze
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Bahrami, G
   Mohammadifard, N
   Haghighatdoost, F
   Emamjomeh, A
   Najafi, F
   Farshidi, H
   Lotfizadeh, M
   Kazemi, T
   Shafiei, S
   Roohafza, H
   Sabri, M
   Sarrafzadegan, N
AF Bahrami, Ghazaleh
   Mohammadifard, Noushin
   Haghighatdoost, Fahimeh
   Emamjomeh, Ali
   Najafi, Farid
   Farshidi, Hossein
   Lotfizadeh, Masoud
   Kazemi, Tooba
   Shafiei, Sania
   Roohafza, Hamidreza
   Sabri, Mohammadreza
   Sarrafzadegan, Nizal
TI The association between soft drinks consumption and risk of mental
   disorders among Iranian adults: The LIPOKAP study
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Sugar sweetened beverage; Soft drink; Mental disorders; Depression;
   Anxiety; Diet
ID METABOLIC SYNDROME; DEPRESSION; ANXIETY; HEALTH; STRATEGIES; SYMPTOMS;
   INDEX
AB Objective: With rising demand for soft drinks (SDs) in low-income countries, studies examining mental disorders in relation to SDs are rather scarce. Therefore, we aimed to explore this association in a sample of Iranian adults. Methods: This cross-sectional study was carried out within the framework of the multi-centric LIPOKAP project, with 1970 Iranian healthy adults. Dietary intake and symptoms of depression and anxiety were collected using validated, Persian versions of a food frequency questionnaire and a Hospital Anxiety and Depression Scale (HADS), respectively. Artificial juices were considered fruit-flavored carbonated sugar beverages, sugar-sweetened beverages (SSB) included fruit-flavored carbonated sugar beverages and carbonated colas, and soft drinks included SSB and drinks containing non-nutritive sweeteners. Results: The mean age of the participants was 39.8 +/- 13.9 years. Compared to lower intake, higher intake of SDs (OR = 1.30, 95 % CI: 1.01, 1.69; P = 0.041), SSBs (OR = 1.30, 95 % CI: 1.00, 1.67; P = 0.045) and artificial juice (OR = 1.63, 95 % CI: 1.24, 2.13; P <0.001) was associated with higher risk of depression in adjusted model. These associations were sex-specific and more evident in males. No significant association was found between any of the drinks and anxiety risk except for artificial juice in men which was directly associated with anxiety risk (OR = 1.66, 95 % CI: 1.06, 2.61; P = 0.028). Conclusion: This study found a positive association between SDs, SSBs and artificial juice and depression, but not anxiety. These associations varied between men and women. Prospective cohort studies are warranted to confirm our results and reveal the causal relationship.
C1 [Bahrami, Ghazaleh] Isfahan Univ Med Sci, Student Res Comm, Esfahan, Iran.
   [Haghighatdoost, Fahimeh; Sarrafzadegan, Nizal] Isfahan Univ Med Sci, Cardiovasc Res Inst, Isfahan Cardiovasc Res Ctr, Esfahan, Iran.
   [Mohammadifard, Noushin] Isfahan Univ Med Sci, Cardiovasc Res Inst, Intervent Cardiol Res Ctr, Esfahan, Iran.
   [Emamjomeh, Ali; Shafiei, Sania] Isfahan Univ Med Sci, Isfahan Cardiovasc Res Inst, Heart Failure Res Ctr, Esfahan, Iran.
   [Najafi, Farid] Kermanshah Univ Med Sci, Hlth Inst, Res Ctr Environm determinants Hlth, Kermanshah, Iran.
   [Farshidi, Hossein] Hormozgan Univ Med Sci, Hormozgan Cardiovasc Res Ctr, Bandarabbas, Iran.
   [Lotfizadeh, Masoud] Shahrekord Univ Med Sci, Sch Hlth, Shahrekord, Iran.
   [Kazemi, Tooba] Birjand Univ Med Sci, Cardiovasc Dis Res Ctr, Birjand, Iran.
   [Roohafza, Hamidreza] Isfahan Univ Med Sci, Cardiovasc Res Inst, Cardiac Rehabil Res Ctr, Esfahan, Iran.
   [Sabri, Mohammadreza] Isfahan Univ Med Sci, Cardiovasc Res Inst, Pediat Cardiovasc Res Ctr, Esfahan, Iran.
   [Sarrafzadegan, Nizal] Univ British Columbia, Fac Med, Sch Populat & Publ Hlth, Vancouver, BC, Canada.
C3 Isfahan University of Medical Sciences; Isfahan University of Medical
   Sciences; Isfahan University of Medical Sciences; Isfahan University of
   Medical Sciences; Kermanshah University of Medical Sciences; Shahrekord
   University Medical Sciences; Birjand University of Medical Sciences;
   Isfahan University of Medical Sciences; Isfahan University of Medical
   Sciences; University of British Columbia
RP Haghighatdoost, F (corresponding author), Isfahan Univ Med Sci, Cardiovasc Res Inst, Isfahan Cardiovasc Res Ctr, Esfahan, Iran.
EM f_haghighatdoost@yahoo.com
RI Najafi, Farid/JSL-1581-2023; Merat, Shahin/A-5478-2009; lotfizadeh,
   masoud/J-9765-2017
OI lotfizadeh, masoud/0000-0002-4694-327X
FU Pfizer Company [11531879]; Isfahan University of medical sciences
   [1402221]
FX This study has been funded by Pfizer Company with grant number 11531879
   and Isfahan University of medical sciences with a grant number of
   1402221.
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NR 40
TC 2
Z9 3
U1 1
U2 4
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD OCT 15
PY 2024
VL 363
BP 8
EP 14
DI 10.1016/j.jad.2024.07.033
EA JUL 2024
PG 7
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA A1W9Z
UT WOS:001280518100001
PM 39019222
DA 2025-06-11
ER

PT J
AU Ferriani, LO
   Silva, DA
   Molina, MDB
   Mill, JG
   Brunoni, AR
   da Fonseca, MDM
   Moreno, AB
   Benseñor, IM
   de Aguiar, OB
   Barreto, SM
   Viana, MC
AF Ferriani, Lara Onofre
   Silva, Daniela Alves
   Molina, Maria del Carmen Bisi
   Mill, Jose Geraldo
   Brunoni, Andre Russowsky
   da Fonseca, Maria de Jesus Mendes
   Moreno, Arlinda B.
   Bensenor, Isabela M.
   de Aguiar, Odaleia Barbosa
   Barreto, Sandhi Maria
   Viana, Maria Carmen
TI Depression is a risk factor for metabolic syndrome: Results from the
   ELSA-Brasil cohort study
SO JOURNAL OF PSYCHIATRIC RESEARCH
LA English
DT Article
DE Metabolic syndrome; Depression; Waist circumference; Cholesterol; Mental
   disorders
ID METAANALYSIS; ABNORMALITIES; ASSOCIATIONS; ORGANIZATION; COMPONENTS;
   SEVERITY; ANXIETY; OBESITY; DISEASE; ADULTS
AB Introduction: Metabolic Syndrome (MetS) and depression comorbidity has been recognized, but its directionality is still uncertain. The aims of this study was to assess the association between depression (diagnosis and severity) and MetS (components, diagnosis and trajectory) in the baseline and over a 4-year follow-up period. Material and methods: Baseline and follow-up data from 13,883 participants of the Brazilian Longitudinal Study of Adult Health were analyzed. The Clinical Interview Schedule Revised assessed depressive episode and its severity. MetS components and diagnosis were assessed according to the National Cholesterol Education Program Adult Treatment Panel III. Participants were grouped according to MetS trajectory as recovered, incident and persistent MetS. Logistic regression analysis was conducted estimating odds ratios (OR) and 95% confidence intervals (95% CI). Results: Baseline depression was positively associated with recovered (OR = 1.59, 95%CI 1.18-2.14), inci-dent (OR = 1.45, 95%CI 1.09-1.91) and persistent (OR = 1.70, 95%CI 1.39-2.07) MetS. Baseline depression was also associated with large waist circumference (OR = 1.47, 95%CI 1.23-1.75), high triglycerides (OR = 1.23, 95%CI 1.02-1.49), low high-density lipoprotein cholesterol (OR = 1.30, 95%CI 1.08-1.56), and hyperglycemia (OR = 1.38, 95%CI 1.15-1.66) at follow-up. Having three or more MetS components at follow-up was associated with baseline depression, with a positive dose-response effect (OR = 1.77, 95%CI 1.29-2.43; OR = 1.79, 95%CI 1.26-2.54; OR = 2.27, 95%CI 1.50-3.46, respectively). The magnitude of associations was greater in severe depression, when compared to moderate and mild. Discussion: These results support that depression is a risk factor for the development of MetS and highlights the need to follow metabolic and cardiovascular alterations in the presence of depression.
C1 [Ferriani, Lara Onofre; Molina, Maria del Carmen Bisi; Mill, Jose Geraldo; Viana, Maria Carmen] Univ Fed Espirito Santo, Postgrad Program Publ Hlth, Vitoria, ES, Brazil.
   [Silva, Daniela Alves] Univ Fed Espirito Santo, Dept Hlth Integrated Educ, Vitoria, ES, Brazil.
   [Molina, Maria del Carmen Bisi] Univ Fed Ouro Preto, Postgrad Program Hlth & Nutr, Ouro Preto, MG, Brazil.
   [Mill, Jose Geraldo] Univ Fed Espirito Santo, Dept Physiol Sci, Vitoria, ES, Brazil.
   [Brunoni, Andre Russowsky; Bensenor, Isabela M.] Univ Sao Paulo, Ctr Clin & Epidemiol Res, Sao Paulo, SP, Brazil.
   [da Fonseca, Maria de Jesus Mendes; Moreno, Arlinda B.] Fundacao Oswaldo Cruz, Nacl Sch Publ Hlth, Dept Epidemiol & Quantitat Methods Hlth, Rio De Janeiro, RJ, Brazil.
   [de Aguiar, Odaleia Barbosa] Univ Estado Rio De Janeiro, Dept Appl Nutr, Rio De Janeiro, RJ, Brazil.
   [Barreto, Sandhi Maria] Univ Fed Minas Gerais, Med Sch, Belo Horizonte, MG, Brazil.
   [Barreto, Sandhi Maria] Univ Fed Minas Gerais, Clin Hosp, Belo Horizonte, MG, Brazil.
   [Viana, Maria Carmen] Univ Fed Espirito Santo, Dept Social Med, Vitoria, ES, Brazil.
C3 Universidade Federal do Espirito Santo; Universidade Federal do Espirito
   Santo; Universidade Federal de Ouro Preto; Universidade Federal do
   Espirito Santo; Universidade de Sao Paulo; Fundacao Oswaldo Cruz;
   Universidade do Estado do Rio de Janeiro; Universidade Federal de Minas
   Gerais; Universidade Federal de Minas Gerais; Universidade Federal do
   Espirito Santo
RP Ferriani, LO (corresponding author), Univ Fed Espirito Santo, Postgrad Program Publ Hlth, Vitoria, ES, Brazil.
EM laraonofref@gmail.com
RI Fonseca, Maria/HTR-3788-2023; Barreto, Sandhi/D-2855-2014; Bensenor,
   Isabela/L-3306-2017; Moreno, Arlinda/H-3975-2013; Russowsky Brunoni,
   Andre/H-8394-2012
OI Barbosa Moreno, Arlinda/0000-0002-8282-6521; Bensenor,
   Isabela/0000-0002-6723-5678; Russowsky Brunoni,
   Andre/0000-0002-6310-3571
FU Brazilian Ministry of Health (Science and Technology Department);
   Brazilian Ministry of Science, Technology and Innovation FINEP; CNPq [01
   06 0010.00, 01.10.0643.03, 01 06 0212.00, 01.10.0742-00, 01 06 0300.00,
   01.12.0284.00, 01 06 0278.00, 01 10 0746 00, 01 06 0115.00,
   01.10.0773-00, 01 06 0071.00, 01.11.0093.01]; Coordenacao de
   Aperfeicoamento de Pessoal de Nivel Superior - Brasil (CAPES); Conselho
   Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) (Bolsa de
   Produtividade em Pesquisa) [314218/2018-1]
FX This study was funded by the Brazilian Ministry of Health (Science and
   Technology Department) and the Brazilian Ministry of Science, Technology
   and Innovation FINEP and CNPq. Grant numbers: 01 06 0010.00 and
   01.10.0643.03 (RS); 01 06 0212.00 and 01.10.0742-00 (BA); 01 06 0300.00
   and 01.12.0284.00 (ES); 01 06 0278.00 and 01 10 0746 00 (MG); 01 06
   0115.00 and 01.10.0773-00 (SP); and 01 06 0071.00 and 01.11.0093.01
   (RJ). This study was partially funded by the Coordenacao de
   Aperfeicoamento de Pessoal de Nivel Superior - Brasil (CAPES). MCV is
   supported by the Conselho Nacional de Desenvolvimento Cientifico e
   Tecnologico (CNPq) (Bolsa de Produtividade em Pesquisa 314218/2018-1).
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NR 46
TC 6
Z9 6
U1 1
U2 4
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-3956
EI 1879-1379
J9 J PSYCHIATR RES
JI J. Psychiatr. Res.
PD FEB
PY 2023
VL 158
BP 56
EP 62
DI 10.1016/j.jpsychires.2022.12.017
EA DEC 2022
PG 7
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 8E6PK
UT WOS:000919092500001
PM 36571912
DA 2025-06-11
ER

PT J
AU Allen, LA
   Shrikrishnapalasuriyar, N
   Rees, DA
AF Allen, Lowri A.
   Shrikrishnapalasuriyar, Natasha
   Rees, Dafydd Aled
TI Long-term health outcomes in young women with polycystic ovary syndrome:
   A narrative review
SO CLINICAL ENDOCRINOLOGY
LA English
DT Review
DE cardiovascular diseases; endometrial carcinoma; hypertension; mental
   health; polycystic ovary syndrome; type 2 diabetes
ID IDIOPATHIC INTRACRANIAL HYPERTENSION; INTIMA-MEDIA THICKNESS;
   CORONARY-HEART-DISEASE; BREAST-CANCER; CARDIOVASCULAR RISK;
   INSULIN-RESISTANCE; DIASTOLIC DYSFUNCTION; ARTERIAL STIFFNESS;
   ENDOMETRIAL CANCER; METABOLIC SYNDROME
AB Polycystic ovary syndrome (PCOS) has long been recognized as a common disorder in young women leading to reproductive and cutaneous sequelae. However, the associated health risks are now known to extend beyond these familiar manifestations to a range of longer-term comorbidities. Here we review the evidence for an association of PCOS with adverse long-term health outcomes, discussing the pathophysiological mechanisms involved in addition to opportunities for therapeutic intervention. Cross-sectional and longitudinal studies point to an increased risk of type 2 diabetes, hypertension and dyslipidaemia, with recent data confirming that these translate to an increased risk of cardiovascular events independently of obesity. Obstructive sleep apnoea, nonalcoholic fatty liver disease and endometrial cancer are also more prevalent, while mental health disorders, notably anxiety and depression, are common but under-appreciated associations. Uncertainties remain as to whether these risks are apparent in all patients with PCOS or are confined to particular subtypes, whether risks persist post-menopausally and how risk may be affected by ethnicity. Further work is also needed in establishing if systematic screening and targeted intervention can lead to improved outcomes. Until such data are available, clinicians managing women with PCOS should counsel patients on long-term health risks and invest in strategies that limit progression to metabolic and non-metabolic morbidities.
C1 [Allen, Lowri A.] Cardiff Univ, Sch Med, Diabetes Res Grp, Cardiff, Wales.
   [Shrikrishnapalasuriyar, Natasha] Univ Hosp Wales, Dept Endocrinol, Cardiff, Wales.
   [Rees, Dafydd Aled] Cardiff Univ, Sch Med, Neurosci & Mental Hlth Res Inst, Hth Pk, Cardiff CF24 4HQ, Wales.
C3 Cardiff University; Cardiff University; Cardiff University
RP Rees, DA (corresponding author), Cardiff Univ, Sch Med, Neurosci & Mental Hlth Res Inst, Hth Pk, Cardiff CF24 4HQ, Wales.
EM reesda@cf.ac.uk
OI Rees, Aled/0000-0002-1165-9092
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NR 99
TC 24
Z9 24
U1 0
U2 16
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0300-0664
EI 1365-2265
J9 CLIN ENDOCRINOL
JI Clin. Endocrinol.
PD AUG
PY 2022
VL 97
IS 2
SI SI
BP 187
EP 198
DI 10.1111/cen.14609
EA OCT 2021
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 2V0JW
UT WOS:000709014100001
PM 34617616
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Juster, RP
   McEwen, BS
   Lupien, SJ
AF Juster, Robert-Paul
   McEwen, Bruce S.
   Lupien, Sonia J.
TI Allostatic load biomarkers of chronic stress and impact on health and
   cognition
SO NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
LA English
DT Review
DE Allostatic load; Chronic stress; Aging; Resilience; Health; Cognition;
   Biomedicine
ID CUMULATIVE BIOLOGICAL RISK; CHRONIC-FATIGUE-SYNDROME; 3RD
   NATIONAL-HEALTH; PHYSIOLOGICAL DYSREGULATION; METABOLIC SYNDROME;
   SOCIOECONOMIC-STATUS; SOCIAL RELATIONSHIPS; CARDIOVASCULAR RISK; GLUCOSE
   ALLOSTASIS; PERCEIVED STRESS
AB The allostatic load model expands the stress-disease literature by proposing a temporal cascade of multi-systemic physiological dysregulations that contribute to disease trajectories. By incorporating an allostatic load index representing neuroendocrine, immune, metabolic, and cardiovascular system functioning, numerous studies have demonstrated greater prediction of morbidity and mortality over and beyond traditional detection methods employed in biomedical practice. This article reviews theoretical and empirical work using the allostatic load model vis-a-vis the effects of chronic stress on physical and mental health. Specific risk and protective factors associated with increased allostatic load are elucidated and policies for promoting successful aging are proposed. (C) 2009 Elsevier Ltd. All rights reserved.
C1 [Juster, Robert-Paul; Lupien, Sonia J.] Univ Montreal, Lab Psychoneuroendocrinol, Ctr Studies Human Stress, Fernand Seguin Res Ctr, Montreal, PQ H3C 3J7, Canada.
   [McEwen, Bruce S.] Rockefeller Univ, Harold & Margaret Milliken Hatch Lab Neuroendocri, New York, NY USA.
C3 Universite de Montreal; Rockefeller University
RP Juster, RP (corresponding author), McGill Univ, Louis H Lafontaine Hosp, Dept Neurol & Neurosurg,Fernand Seguin Res Ctr, Lab Psychoneuroendocrinol,Ctr Studies Human Stres, 7401 Hochelaga,Louis Riel Pavil,Unit 226,Room RI, Montreal, PQ H1N 3M5, Canada.
EM robert.juster@mail.mcgill.ca
RI McEwen, Bruce/Z-1630-2019
OI Juster, Robert Paul/0000-0003-4133-4042
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NR 137
TC 1759
Z9 2181
U1 11
U2 447
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0149-7634
EI 1873-7528
J9 NEUROSCI BIOBEHAV R
JI Neurosci. Biobehav. Rev.
PD SEP
PY 2010
VL 35
IS 1
SI SI
BP 2
EP 16
DI 10.1016/j.neubiorev.2009.10.002
PG 15
WC Behavioral Sciences; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Behavioral Sciences; Neurosciences & Neurology
GA 654XX
UT WOS:000282205600002
PM 19822172
DA 2025-06-11
ER

PT J
AU Sanders, RH
   Han, A
   Baker, JS
   Cobley, S
AF Sanders, Ross H.
   Han, Ahreum
   Baker, Julien S.
   Cobley, Stephen
TI Childhood obesity and its physical and psychological co-morbidities: a
   systematic review of Australian children and adolescents
SO EUROPEAN JOURNAL OF PEDIATRICS
LA English
DT Review
DE Obesity; Overweight; Co-morbidity; Systematic review; Childhood;
   Adolescents; Australia
ID BODY-MASS INDEX; QUALITY-OF-LIFE; CARDIOVASCULAR RISK-FACTORS;
   CORONARY-HEART-DISEASE; MENTAL-HEALTH PROBLEMS; WAIST CIRCUMFERENCE;
   METABOLIC SYNDROME; BLOOD-PRESSURE; SELF-ESTEEM; SCHOOL-CHILDREN
AB Australia is predicted to have the highest overweight/obesity rate in the world by 2022 outranking the USA and UK. The purpose of this systematic review was to evaluate the associations between childhood obesity and physical and psychological health co-morbidities. Therefore, a systematic literature search was conducted from six databases (2004-2014). Studies were included if they investigated obesity-related co-morbidities with participants residing in Australia aged 0-18 years. Forty-seven studies fulfilled selection criteria. Evidence suggests that overweight/obese Australian children and adolescents, compared to normal-weight peers, had more cardio-metabolic risk factors and higher risk factors of non-alcohol fatty liver disease and were experiencing more negative psychological outcomes (depression, low self-esteem and lower scores of health-related quality of life). Many other health consequences have either not been investigated in Australia, or as frequently as in other countries.
   Conclusions: Given Australia's current overweight/obesity prevalence and trajectory, Australia-based studies are needed to identify the suspected co-morbidities, understand the range of individual, social and environmental mechanisms driving obesity, and help identify policies, interventions and strategies that will change the future trajectory and 'disease burden' both in Australia and internationally.
C1 [Sanders, Ross H.; Han, Ahreum; Cobley, Stephen] Univ Sydney, Exercise & Sport Sci, Fac Hlth Sci, Sydney, NSW 2141, Australia.
   [Baker, Julien S.] Univ West Scotland, Inst Clin Exercise & Hlth Sci, Appl Physiol Res Lab, Sch Sci & Sport, Hamilton ML3 OJB, Scotland.
C3 University of Sydney
RP Sanders, RH (corresponding author), Univ Sydney, Exercise & Sport Sci, Fac Hlth Sci, Cumberland Campus C42,75 East St, Sydney, NSW 2141, Australia.
EM ross.sanders@sydney.edu.au; Ahreum.han@sydney.edu.au; jsbaker@uws.ac.uk;
   stephen.cobley@sydney.edu.au
RI ; Cobley, Stephen/I-5686-2017
OI Sanders, Ross/0000-0003-0489-3048; Cobley, Stephen/0000-0001-6099-392X
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   World Health Organization, GLOB HLTH OBS GHO OV
   World Health Organization, OB OV, V2014
NR 106
TC 180
Z9 198
U1 1
U2 68
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0340-6199
EI 1432-1076
J9 EUR J PEDIATR
JI Eur. J. Pediatr.
PD JUN
PY 2015
VL 174
IS 6
BP 715
EP 746
DI 10.1007/s00431-015-2551-3
PG 32
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Pediatrics
GA CI6WP
UT WOS:000354904800002
PM 25922141
DA 2025-06-11
ER

PT J
AU Aschbacher, K
   Kornfeld, S
   Picard, M
   Puterman, E
   Havel, PJ
   Stanhope, K
   Lustig, RH
   Epel, E
AF Aschbacher, Kirstin
   Kornfeld, Sarah
   Picard, Martin
   Puterman, Eli
   Havel, Peter J.
   Stanhope, Kimber
   Lustig, Robert H.
   Epel, Elissa
TI Chronic stress increases vulnerability to diet-related abdominal fat,
   oxidative stress, and metabolic risk
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE Psychological stress; Obesity; Abdominal adiposity; Metabolic syndrome;
   Pre-diabetes
ID ACUTE PSYCHOLOGICAL STRESS; INSULIN-RESISTANCE; DEPRESSIVE SYMPTOMS;
   CORTISOL REACTIVITY; VISCERAL FAT; OBESITY; DISEASE; CAREGIVERS;
   HYPOTHESIS; MORTALITY
AB Background: In preclinical studies, the combination of chronic stress and a high sugar/fat diet is a more potent driver of visceral adiposity than diet alone, a process mediated by peripheral neuropeptide Y (NPY).
   Methods: In a human model of chronic stress, we investigated whether the synergistic combination of highly palatable foods (HPF; high sugar/fat) and stress was associated with elevated metabolic risk. Using a case-control design, we compared 33 post-menopausal caregivers (the chronic stress group) to 28 age-matched low-stress control women on reported HPF consumption (modified Block Food Frequency Questionnaire), waistline circumference, truncal fat ultrasound, and insulin sensitivity using a 3-h oral glucose tolerance test. A fasting blood draw was assayed for plasma NPY and oxidative stress markers (8-hydroxyguanosine and F2-Isoprostanes).
   Results: Among chronically stressed women only, greater HPF consumption was associated with greater abdominal adiposity, oxidative stress, and insulin resistance at baseline (all p's <= .01). Furthermore, plasma NPY was significantly elevated in chronically stressed women (p < .01), and the association of HPF with abdominal adiposity was stronger among women with high versus low NPY. There were no significant predictions of change over 1-year, likely due to high stability (little change) in the primary outcomes over this period.
   Discussion: Chronic stress is associated with enhanced vulnerability to diet-related metabolic risk (abdominal adiposity, insulin resistance, and oxidative stress). Stress-induced peripheral NPY may play a mechanistic role. (C) 2014 Published by Elsevier Ltd.
C1 [Aschbacher, Kirstin; Puterman, Eli; Epel, Elissa] Univ Calif San Francisco, Dept Psychiat, San Francisco, CA USA.
   [Aschbacher, Kirstin] Inst Integrat Hlth, Baltimore, MD USA.
   [Kornfeld, Sarah] Alliant Int Univ, Calif Sch Profess Psychol, San Francisco, CA USA.
   [Picard, Martin] Childrens Hosp Philadelphia, Ctr Mitochondrial & Epigen Med, Philadelphia, PA 19104 USA.
   [Picard, Martin] Univ Penn, Philadelphia, PA 19104 USA.
   [Havel, Peter J.; Stanhope, Kimber] Univ Calif Davis, Dept Mol Biosci & Nutr, Davis, CA 95616 USA.
   [Lustig, Robert H.] Univ Calif San Francisco, Dept Pediat, San Francisco, CA USA.
   [Lustig, Robert H.] Univ Calif San Francisco, Inst Hlth Policy Studies, San Francisco, CA USA.
C3 University of California System; University of California San Francisco;
   Alliant International University; University of Pennsylvania;
   Pennsylvania Medicine; Childrens Hospital of Philadelphia; University of
   Pennsylvania; University of California System; University of California
   Davis; University of California System; University of California San
   Francisco; University of California System; University of California San
   Francisco
RP Aschbacher, K (corresponding author), Dept Psychiat, 3333 Calif St,Suite 465, San Francisco, CA 94143 USA.
EM kirstin.aschbacher@ucsf.edu; EEpel@lppi.ucsf.edu
RI Havel, Peter/AFU-9329-2022; Puterman, Eli/AAA-5237-2022; Lustig,
   Robert/O-9380-2019; Epel, Elissa/ABI-6703-2022; Stefanadis,
   Christodoulos/ABH-2232-2020
OI Stefanadis, Christodoulos/0000-0001-5974-6454; Puterman,
   Eli/0000-0002-5898-2348; Havel, Peter/0000-0003-3652-8301; Picard,
   Martin/0000-0003-2835-0478
FU NIH/NIA [R01 AG030424-01A2]; NIH/NHLBI grant [K23 HL112955]; NIH/NCRR
   UCSF-CTSI grant [UL1 RR024131]; NIH/NCATS; Marchionne Foundation;
   Institute for Integrative Health; UCSF-CTSI [UL1 TR000004];  [P01
   AT005013]
FX NIH/NIA R01 AG030424-01A2, NIH/NHLBI grant K23 HL112955, NIH/NCRR
   UCSF-CTSI grant No. UL1 RR024131, NIH/NCATS, UCSF-CTSI UL1 TR000004, P01
   AT005013, the Marchionne Foundation and The Institute for Integrative
   Health. The content is solely the responsibility of the authors and does
   not necessarily represent the official views of the NIH. The funders had
   no role in study design, data collection and analysis, decision to
   publish or preparation of the manuscript.
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NR 36
TC 94
Z9 104
U1 0
U2 42
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD AUG
PY 2014
VL 46
BP 14
EP 22
DI 10.1016/j.psyneuen.2014.04.003
PG 9
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA AK4RZ
UT WOS:000338413100002
PM 24882154
OA Green Published, Green Accepted
DA 2025-06-11
ER

PT J
AU McIntyre, RS
   Calabrese, JR
AF McIntyre, Roger S.
   Calabrese, Joseph R.
TI Bipolar depression: the clinical characteristics and unmet needs of a
   complex disorder
SO CURRENT MEDICAL RESEARCH AND OPINION
LA English
DT Review
DE Bipolar depression; bipolar disorder; atypical antipsychotics; mood
   stabilizers; misdiagnosis; comorbid conditions
ID TREATMENT ENHANCEMENT PROGRAM; WEEKLY SYMPTOMATIC STATUS; SUBSTANCE USE
   DISORDERS; QUALITY-OF-LIFE; I-DISORDER; MAJOR DEPRESSION; MOOD
   DISORDERS; FUNCTIONAL IMPAIRMENT; MEDICAL COMORBIDITY; METABOLIC
   SYNDROME
AB Objective: We reviewed important clinical aspects of bipolar depression, a progressive psychiatric condition that is commonly treated in primary care. Bipolar depression is associated with considerable burden of illness, high suicide risk, and greater morbidity and mortality than bipolar mania. Methods: We identified articles relevant to our narrative review using a multistep search of the literature and applying terms that were relevant to bipolar depression or bipolar disorder. Results: Bipolar depression accounts for the majority of time spent unwell for patients with bipolar disorder; high rates of morbidity and mortality arise from full symptomatic episodes and interepisode subsyndromal symptoms. Bipolar depression is an important contributor to long-term dysfunction for patients with bipolar disorder due to psychosocial impairment, loss of work productivity and high rates of substance abuse. Missed and delayed diagnosis is prevalent due to overlapping symptoms with unipolar depression and other diagnoses. Medical comorbidities (i.e. cardiovascular disease, hypertension, obesity, metabolic syndrome) and psychiatric comorbidities (i.e. anxiety disorder, personality disorder, eating disorder, attention-deficit/hyperactivity disorder) are common. Currently, only three treatments are FDA-approved for bipolar depression; monotherapy antidepressants are not a recommended treatment option. Conclusions: Bipolar disorder is common among primary care patients presenting with depression; it is often treated exclusively in primary care. Clinicians should be alert for symptoms of bipolar disorder in undiagnosed patients, know what symptoms probabilistically suggest bipolar versus unipolar depression, have expertise in providing ongoing treatment to diagnosed patients, and be knowledgeable about managing common medication-related side effects and comorbidities. Prompt and accurate diagnosis is critical.
C1 [McIntyre, Roger S.] Univ Hlth Network, Mood Disorders Psychopharmacol Unit, Toronto, ON, Canada.
   [Calabrese, Joseph R.] Univ Hosp Cleveland Med Ctr, Cleveland, OH USA.
C3 University of Toronto; University Health Network Toronto; University
   Hospitals of Cleveland
RP McIntyre, RS (corresponding author), Univ Hlth Network, 399 Bathurst St,MP 9-325, Toronto, ON M5T 2S8, Canada.
EM roger.mcintyre@uhn.ca
RI McIntyre, Roger/AAU-1000-2020
FU Allergan
FX This manuscript was supported by funding from Allergan. The authors had
   full control of the content and approved the final version.
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NR 118
TC 95
Z9 100
U1 0
U2 30
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0300-7995
EI 1473-4877
J9 CURR MED RES OPIN
JI Curr. Med. Res. Opin.
PD NOV 2
PY 2019
VL 35
IS 11
BP 1993
EP 2005
DI 10.1080/03007995.2019.1636017
EA AUG 2019
PG 13
WC Medicine, General & Internal; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine; Research & Experimental Medicine
GA JF4MW
UT WOS:000479220700001
PM 31311335
OA hybrid
DA 2025-06-11
ER

PT J
AU Chan, II
AF Chan, Io Ieong
TI Blunted cortisol as a biomarker of depression based on the attenuation
   hypothesis: A Mendelian randomization analysis using depression as
   exposure
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Depression; Cortisol; Mendelian randomization; Biomarker; Genetics
ID PSYCHIATRIC-DISORDERS; GLUCOCORTICOID-RECEPTOR; MENTAL-HEALTH; STRESS;
   INSTRUMENTS; AXIS; BIAS; SENSITIVITY; RECURRENCE; CHALLENGES
AB Background: Both elevated and blunted cortisol responses have been associated with depression. Previous Mendelian randomization (MR) studies have largely ruled out cortisol as a cause of depression. Based on the attenuation hypothesis, this MR study used depression as exposure to assess whether cortisol might be a consequence and therefore a biomarker of depression. Methods: Strong (P < 5 x 10(-8)) and independent (r(2) < 0.001) single nucleotide polymorphisms (SNPs) associated with broadly defined depression (294,322 cases, 741,438 controls) were used as instruments. These were applied to genetic associations with morning, fasting, and random plasma cortisol in the CORtisol NETwork (CORNET) consortium (n = 25,314), METabolic Syndrome in Men (METSIM) study (n = 6667), and Canadian Longitudinal Study on Aging (CLSA) cohort (n = 8299). Multivariable MR, adjusting for childhood maltreatment and major mental disorders, was conducted to address potential horizontal pleiotropy from dichotomous depression. Instruments were also selected by evidence of colocalization with major depressive disorder to address non-specificity. Results: Using 133 SNPs as instruments, depression was inversely associated with morning plasma cortisol (beta per log-odds of genetic liability to depression = -0.107 [95 % CI, -0.181 to -0.032]) in the CORNET consortium. Replication in the METSIM study (beta = -0.203 [95 % CI, -0.367 to -0.040]) and CLSA cohort (beta = -0.091 [95 % CI, -0.220 to 0.039]) showed consistent but not always significant associations. Multivariable MR and follow-up analysis incorporating colocalization supported these findings. Conclusions: Consistent with the attenuation hypothesis, blunted cortisol response appeared to be a consequence and potentially a biomarker of depression. Future studies are needed to provide more interpretable effect sizes and validate other biomarker measures.
C1 [Chan, Io Ieong] Univ Macau, Fac Hlth Sci, Dept Publ Hlth & Med Adm, Macau, Peoples R China.
C3 University of Macau
RP Chan, II (corresponding author), Univ Macau, Fac Hlth Sci, Dept Publ Hlth & Med Adm, Macau, Peoples R China.
EM ioieongchan@um.edu.mo
RI Chan, Io Ieong/AAE-7640-2022
OI Chan, Io Ieong/0000-0001-9619-6535
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NR 112
TC 0
Z9 0
U1 1
U2 1
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD MAY 1
PY 2025
VL 376
BP 398
EP 409
DI 10.1016/j.jad.2025.02.016
EA FEB 2025
PG 12
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA Y1Y7C
UT WOS:001430171800001
PM 39961449
DA 2025-06-11
ER

PT J
AU Takuma, K
   Ago, Y
   Matsuda, T
AF Takuma, Kazuhiro
   Ago, Yukio
   Matsuda, Toshio
TI Preventive Effects of an Enriched Environment on Rodent Psychiatric
   Disorder Models
SO JOURNAL OF PHARMACOLOGICAL SCIENCES
LA English
DT Article
DE psychiatric disorder; gene-environmental interaction; environmental
   enrichment
ID CYCLASE-ACTIVATING POLYPEPTIDE; DEPENDENT PLASTICITY; MICE;
   SCHIZOPHRENIA; RELEVANCE; REVERSES
AB Interplay between genetic and environmental factors plays a key role in psychiatric disorders, as well as other brain diseases, cancer, and metabolic syndrome. In accordance with epidemiological findings, animal studies have pointed out the importance of a variety of environmental factors, such as viral infection during pregnancy or infancy, early parental loss or separation, and physical or sexual abuse in early life, in the etiology of psychiatric disorders. Conversely, positive effects of environmental factors against the pathogenesis of psychiatric disorders are also demonstrated, in which most of the animals are exposed to an "enriched environment". This review summarizes recent progress of research in this field focusing on the preventive effects of an "enriched environment" against the expression of behavioral abnormalities in rodent models of psychiatric disorders.
C1 [Takuma, Kazuhiro; Ago, Yukio; Matsuda, Toshio] Osaka Univ, Grad Sch Pharmaceut Sci, Lab Med Pharmacol, Suita, Osaka 5650871, Japan.
   [Matsuda, Toshio] Kanazawa Univ, Osaka Univ, United Grad Sch Child Dev, Suita, Osaka 5650871, Japan.
   [Matsuda, Toshio] Hamamatsu Univ Sch Med, Suita, Osaka 5650871, Japan.
C3 The University of Osaka; The University of Osaka; Kanazawa University
RP Matsuda, T (corresponding author), Osaka Univ, Grad Sch Pharmaceut Sci, Lab Med Pharmacol, 1-6 Yamadaoka, Suita, Osaka 5650871, Japan.
EM matsuda@phs.osaka-u.ac.jp
RI Ago, Yukio/H-9142-2019; Takuma, Kazuhiro/A-6162-2012
OI Ago, Yukio/0000-0001-7562-4000
FU Japan Society for the Promotion of Science; Ministry of Education,
   Culture, Sports, Science, and Technology of Japan
FX This study was supported in part by Grants-in-Aid for Scientific
   Research from the Japan Society for the Promotion of Science and the
   Ministry of Education, Culture, Sports, Science, and Technology of
   Japan.
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NR 30
TC 26
Z9 29
U1 0
U2 5
PU JAPANESE PHARMACOLOGICAL SOC
PI KYOTO
PA EDITORIAL OFF, KANTOHYA BLDG GOKOMACHI-EBISUGAWA NAKAGYO-KU, KYOTO, 604,
   JAPAN
SN 1347-8613
J9 J PHARMACOL SCI
JI J. Pharmacol. Sci.
PD OCT
PY 2011
VL 117
IS 2
BP 71
EP 76
DI 10.1254/jphs.11R07CP
PG 6
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 837RI
UT WOS:000296220500001
PM 21881295
OA Bronze
DA 2025-06-11
ER

PT J
AU Sanchez-Carazo, JL
   López-Estebaranz, JL
   Guisado, C
AF Luis Sanchez-Carazo, Jose
   Luis Lopez-Estebaranz, Jose
   Guisado, Cristina
TI Comorbidities and health-related quality of life in Spanish patients
   with moderate to severe psoriasis: A cross-sectional study (Arizona
   study)
SO JOURNAL OF DERMATOLOGY
LA English
DT Article
DE arthritis; cardiovascular diseases; comorbidities; psoriasis; quality of
   life
ID LATENT TUBERCULOSIS INFECTION; METABOLIC SYNDROME;
   MYOCARDIAL-INFARCTION; WAIST CIRCUMFERENCE; WEIGHT CHANGE; INDEX DLQI;
   PREVALENCE; DISEASE; RISK; OBESITY
AB Psoriasis is a common, chronic inflammatory immunologically mediated disease of the skin, showing a high prevalence of associated comorbidities, and strongly affecting patients' health-related quality of life (HR-QOL), with profound impact on the psychological aspect. We aimed to establish the correlation between HR-QOL and the associated comorbidities in patients with moderate to severe psoriasis in Spain. A cross-sectional, observational, epidemiological study was conducted at 68 dermatology-based centers across Spain. From October 2010 to June 2011, all adult patients diagnosed with moderate to severe psoriasis at least 6 months prior to the study visit and receiving or not receiving treatment for psoriasis were eligible for inclusion. A total of 1022 patients were included. The study population showed mean 36-item short-form (SF-36) physical and mental health scores and Dermatological Life Quality Index (DLQI) of 49.7, 46.2 and 5.3, respectively. The multiple linear regression models showed that patients with moderate to severe psoriasis and a diagnosis of psoriatic arthritis (PsA), hypertension, diabetes mellitus, sleep disturbances or obesity were found to have lower SF-36 health physical scores. Female patients with depression or anxiety disorders had lower SF-36 health mental scores. Patients diagnosed with moderate to severe psoriatic disease and associated anxiety disorder had greater DLQI scores. Moderate to severe psoriasis has a significant burden on the HR-QOL of patients. Regardless of sex, patients with several comorbidities such as PsA, hypertension or obesity were found to have worse scores in the physical component of the QOL questionnaire, whilst women were more affected in the mental health component than men.
C1 [Luis Sanchez-Carazo, Jose] Gen Univ Hosp Valencia, Valencia, Spain.
   [Luis Lopez-Estebaranz, Jose] Acad Fdn Hosp Alcorcon, Madrid, Spain.
   [Guisado, Cristina] Med Affairs Dept, Janssen, Spain.
C3 Alcorcon Foundation University Hospital
RP Sanchez-Carazo, JL (corresponding author), Hosp Gen Univ, Tres Cruces 2, Valencia 46005, Spain.
EM sanchez_joscar@gva.es
RI Estebaranz, Jose/AAF-1756-2019; Lopez Estebaranz, Jose Luis/L-2920-2018
OI Lopez Estebaranz, Jose Luis/0000-0002-8816-1989
FU Janssen-Cilag, Spain; Jansen-Cilag
FX The authors would like to thank the clinicians and nurses from the
   different participating sites for collecting the data on their patients:
   Alberto Conde Taboada, Alejandro Ballestero Coromina, Alicia Quesada
   Cortes, Amparo Perez Ferriols, Ana Belen Piteiro Bermejo, Ander Zulaica
   Garate, Angel Lopez Avila, Angel Palomo Avellano, Beatriz Gonzalez
   Sixto, Benjamin Pineiro Alvarez, Carlos Ferrandiz Foraster, Carlos
   Gonzalez Herrera, Carlos Veiga Codesido, Carmen Carranza Romero,
   Carolina Medina Gil, Conrad Puyol Marco, Cristina Rodriguez Garcia,
   Diana Ruiz Genao, Eduardo Lopez de Ayala Casado, Elena Arnal Cardenal,
   Elena Galla Gutierrez, Elena Sanchez Gomez, Elena Sanchez Lago, Elena
   Soler Cruz, Elena Sotomayor Lopez, Emilia Fernandez Lopez, Emilio Suarez
   Martin, Enrique Gimeno Carpio, Enrique Herrera Ceballos, Esteban Dauden
   Tello, Esther Quedecedo Estebanez, Federica Liuti, Fernando Millan
   Parrilla, Fernando Allegue Gallego, Fernando Cabo Gomez, Fernando Pulgar
   Martin, Fernando Rodriguez Garcia, Fernando Toledo Arberola, Francisco
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   was provided by Ana Lopez and Antonio Torres at Dynamic S.L., during the
   preparation of this paper, was supported by Janssen-Cilag, Spain.
   Responsibility for opinions, conclusions and interpretation of data lies
   entirely with the authors. This study was financed by Jansen-Cilag.
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NR 36
TC 54
Z9 56
U1 1
U2 10
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0385-2407
EI 1346-8138
J9 J DERMATOL
JI J. Dermatol.
PD AUG
PY 2014
VL 41
IS 8
BP 673
EP 678
DI 10.1111/1346-8138.12465
PG 6
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA AN4AS
UT WOS:000340530600001
PM 24942203
DA 2025-06-11
ER

PT J
AU Herbert, S
   Woolf, K
AF Herbert, Shannon
   Woolf, Kathleen
TI Moving beyond Weight: A Narrative Review of the Dietary and Lifestyle
   Management for Reducing Cardiometabolic Risk in Polycystic Ovary
   Syndrome (PCOS)
SO NUTRIENTS
LA English
DT Review
DE polycystic ovary syndrome; cardiometabolic risk; body weight; weight
   management; dietary patterns
ID HORMONE BINDING GLOBULIN; OBESE WOMEN; INSULIN-RESISTANCE; OVERWEIGHT
   WOMEN; OXIDATIVE STRESS; LIPID PROFILES; GLYCEMIC INDEX; METABOLIC
   PROFILES; GLUCOSE-TOLERANCE; HYPOCALORIC DIET
AB Polycystic ovary syndrome (PCOS) is the most common endocrine disorder experienced by women. PCOS is a lifelong condition associated with reproductive, metabolic, and psychological presentations. PCOS is also linked with increased prevalence of cardiometabolic risk factors. While an association between body weight and PCOS has been noted, cardiometabolic risk factors are prevalent in individuals with PCOS across body weights. Currently, no consensus exists as to the most appropriate lifestyle strategy for mitigating cardiometabolic risk in PCOS. A large proportion of the literature is focused on weight loss for individuals with PCOS who are overweight or experience obesity, despite PCOS being prevalent across body sizes. The aim of this narrative review is to assess dietary and lifestyle interventions aimed at reducing cardiometabolic risk in individuals with PCOS across body sizes. A total of 51 articles are included in this review. Overall, randomized controlled trials are limited and most studies focus on weight loss, excluding individuals classified within a healthy body weight range. Studies that modified the dietary pattern without an energy deficit saw improvements in cardiometabolic risk. Thus, less restrictive dietary approaches may be effective at reducing cardiometabolic risk in this population. This review also highlights the need for more sustainable lifestyle interventions that meet the needs of individuals with PCOS of varying body weights.
C1 [Herbert, Shannon; Woolf, Kathleen] NYU, Steinhart Sch Culture Educ & Human Dev, Dept Nutr & Food Studies, New York, NY 10003 USA.
C3 New York University
RP Woolf, K (corresponding author), NYU, Steinhart Sch Culture Educ & Human Dev, Dept Nutr & Food Studies, New York, NY 10003 USA.
EM slh465@nyu.edu; kathleen.woolf@nyu.edu
OI Herbert, Shannon/0009-0003-6031-6007
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NR 123
TC 5
Z9 7
U1 3
U2 9
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD DEC
PY 2023
VL 15
IS 24
AR 5069
DI 10.3390/nu15245069
PG 36
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA DG0J5
UT WOS:001130755000001
PM 38140328
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Pedersen, ALW
   Gildberg, FA
   Hjorth, P
   Hojlund, M
   Andersen, K
AF Pedersen, Anne Louise Winkler
   Gildberg, Frederik Alkier
   Hjorth, Peter
   Hojlund, Mikkel
   Andersen, Kjeld
TI Hospitalisation time is associated with weight gain in forensic mental
   health patients with schizophrenia or bipolar disorder
SO NORDIC JOURNAL OF PSYCHIATRY
LA English
DT Article
DE Forensic psychiatry; body weight; blood pressure; blood lipids;
   hospitalisation
ID METABOLIC SYNDROME; PREVALENCE; OBESITY; POPULATION; OVERWEIGHT;
   MORTALITY; RISK
AB Introduction People with mental disorders have higher mortality from lifestyle diseases than the general population. Forensic mental health patients (FMHPs) are often hospitalised for longer periods of time than non-FMHPs. Thus, hospitalisation may have a greater effect on the risk of lifestyle diseases in FMHPs. Objective Investigate associations between proportional hospitalisation time (PHT) and change in body weight or other cardiometabolic risk factors among FMHPs. Methods Retrospective cohort study including all FMHPs with schizophrenia or bipolar disorder, prescribed antipsychotics, and treated between 01 January 2016 and 06 April 2020 in the Region of Southern Denmark either in forensic units or as outpatients. Associations between PHT and, respectively, primary and secondary outcomes were analysed using linear regression. PHT was determined between each measurement of the outcomes as the number of days hospitalised divided by the total number of days within the time-period. The primary outcome was weight change and secondary outcomes were change in waist circumference (WC), blood pressure, estimated average glucose (eAG), HDL, LDL, total cholesterol, and triglycerides. Analyses were adjusted for gender, age, smoking, and antipsychotics. Results The cohort included 490 FMHPs, of which 440 were diagnosed with schizophrenia. PHT had a significant positive dose-response association with weight change, with an estimated difference of +4.0 kg/year for FMHPs who were hospitalised 100% of the time, compared to FMHPs who were exclusively treated as outpatients. The association interacted with baseline BMI. From the secondary outcomes, the association with PHT was only statistically significant for WC. Conclusions PHT was positively associated with weight gain.
C1 [Pedersen, Anne Louise Winkler; Gildberg, Frederik Alkier; Hjorth, Peter] Univ Southern Denmark, Fac Hlth Sci, Inst Reg Hlth Res, CPS, Odense, Denmark.
   [Pedersen, Anne Louise Winkler; Gildberg, Frederik Alkier] Mental Hlth Serv Reg Southern Denmark, Dept Psychiat Middelfart, Middelfart, Denmark.
   [Hjorth, Peter] Mental Hlth Serv Reg Southern Denmark, Dept Psychiat Vejle, Vejle, Denmark.
   [Hojlund, Mikkel] Univ Southern Denmark, Inst Publ Hlth, Fac Hlth Sci, Clin Pharmacol Pharm & Environm Med, Odense, Denmark.
   [Hojlund, Mikkel] Mental Hlth Serv Reg Southern Denmark, Dept Psychiat Aabenraa, Aabenraa, Denmark.
   [Andersen, Kjeld] Mental Hlth Serv Reg Southern Denmark, Univ Clin, Dept Mental Hlth Odense, Odense, Denmark.
C3 University of Southern Denmark; University of Southern Denmark;
   University of Southern Denmark
RP Pedersen, ALW (corresponding author), Univ Southern Denmark, Fac Hlth Sci, Inst Reg Hlth Res, CPS, Odense, Denmark.
EM anne.louise.pedersen@rsyd.dk
RI Højlund, Mikkel/ISA-6751-2023; Andersen, Kjeld/K-2169-2014; Gildberg,
   Frederik/K-6577-2013; Hojlund, Mikkel/I-8745-2019
OI Andersen, Kjeld/0000-0003-0456-5634; Hjorth, Peter/0000-0001-7548-5848;
   Gildberg, Frederik/0000-0001-9075-6108; Hojlund,
   Mikkel/0000-0002-5786-5203; Pedersen, Anne Louise
   Winkler/0000-0002-5257-9224
FU Psychiatry Research Fund in the Region of Southern Denmark [180811031];
   University of Southern Denmark [Syddansk Universitet]
FX This work was supported by The Psychiatry Research Fund in the Region of
   Southern Denmark [project number 180811031] and University of Southern
   Denmark [Syddansk Universitet].
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NR 33
TC 6
Z9 6
U1 0
U2 0
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0803-9488
EI 1502-4725
J9 NORD J PSYCHIAT
JI Nord. J. Psychiatr.
PD JAN 3
PY 2023
VL 77
IS 1
BP 46
EP 54
DI 10.1080/08039488.2022.2053202
EA APR 2022
PG 9
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 7M2XU
UT WOS:000779280100001
PM 35389309
DA 2025-06-11
ER

PT J
AU Ruzzin, J
   Petersen, R
   Meugnier, E
   Madsen, L
   Lock, EJ
   Lillefosse, H
   Ma, T
   Pesenti, S
   Sonne, SB
   Marstrand, TT
   Malde, MK
   Du, ZY
   Chavey, C
   Fajas, L
   Lundebye, AK
   Brand, CL
   Vidal, H
   Kristiansen, K
   Froyland, L
AF Ruzzin, Jerome
   Petersen, Rasmus
   Meugnier, Emmanuelle
   Madsen, Lise
   Lock, Erik-Jan
   Lillefosse, Haldis
   Ma, Tao
   Pesenti, Sandra
   Sonne, Si Brask
   Marstrand, Troels Torben
   Malde, Marian Kjellevold
   Du, Zhen-Yu
   Chavey, Carine
   Fajas, Lluis
   Lundebye, Anne-Katrine
   Brand, Christian Lehn
   Vidal, Hubert
   Kristiansen, Karsten
   Froyland, Liver
TI Persistent Organic Pollutant Exposure Leads to Insulin Resistance
   Syndrome
SO ENVIRONMENTAL HEALTH PERSPECTIVES
LA English
DT Article
DE contaminants; farmed salmon; metabolic syndrome; nonalcoholic fatty
   liver; obesity; pollution; public health; type 2 diabetes
ID FISH-OIL; MITOCHONDRIAL DYSFUNCTION; RECEPTOR SUBSTRATE-1; OXIDATIVE
   STRESS; ATLANTIC SALMON; SKELETAL-MUSCLE; VEGETABLE-OIL; RHO-KINASE;
   PROTEIN; DIOXINS
AB BACKGROUND: The incidence of the insulin resistance syndrome has increased at an alarming rate worldwide, creating a serious challenge to public health care in the 21st century. Recently, epidemiological studies have associated the prevalence of type 2 diabetes with elevated body burdens of persistent organic pollutants (POPs). However, experimental evidence demonstrating a causal link between POPs and the development of insulin resistance is lacking.
   OBJECTIVE: We investigated whether exposure to POPs contributes to insulin resistance and metabolic disorders.
   METHODS: Sprague-Dawley rats were exposed for 28 days to lipophilic POPs through the consumption of a high-fat diet containing either refined or crude fish oil obtained from farmed Atlantic salmon. In addition, differentiated adipocytes were exposed to several POP mixtures that mimicked the relative abundance of organic pollutants present in crude salmon oil. We measured body weight, whole-body insulin sensitivity, POP accumulation, lipid and glucose homeostasis, and gene expression and we performed microarray analysis.
   RESULTS: Adult male rats exposed to crude, but not refined, salmon oil developed insulin resistance, abdominal obesity, and hepatosteatosis. The contribution of POPs to insulin resistance was confirmed in cultured adipocytes where POPs, especially organochlorine pesticides, led to robust inhibition of insulin action. Moreover, POPs induced down-regulation of insulin-induced gene-1 (Insig-1) and Lpin1, two master regulators of lipid homeostasis.
   CONCLUSION: Our findings provide evidence that exposure to POPs commonly present in food chains leads to insulin resistance and associated metabolic disorders.
C1 [Ruzzin, Jerome; Madsen, Lise; Lock, Erik-Jan; Lillefosse, Haldis; Malde, Marian Kjellevold; Du, Zhen-Yu; Lundebye, Anne-Katrine; Froyland, Liver] NIFES, Natl Inst Nutr & Seafood Res, N-5817 Bergen, Norway.
   [Petersen, Rasmus; Ma, Tao] Univ So Denmark, Dept Biochem & Mol Biol, Odense, Denmark.
   [Petersen, Rasmus; Madsen, Lise; Ma, Tao; Sonne, Si Brask; Kristiansen, Karsten] Univ Copenhagen, Dept Biol, Copenhagen, Denmark.
   [Meugnier, Emmanuelle; Pesenti, Sandra; Vidal, Hubert] Univ Lyon 1, INSERM, U870, INRA,U1235,Inst Natl Sci Appl Lyon, Oullins, France.
   [Meugnier, Emmanuelle; Pesenti, Sandra; Vidal, Hubert] Hosp Civils Lyon, Oullins, France.
   [Marstrand, Troels Torben] Univ Copenhagen, Dept Biol, Bioinformat Ctr, Copenhagen, Denmark.
   [Marstrand, Troels Torben] Univ Copenhagen, Biotech Res & Innovat Ctr, Copenhagen, Denmark.
   [Chavey, Carine; Fajas, Lluis] INSERM, U896, Metab & Canc Lab, Inst Rech Cancerol Montpellier, Montpellier, France.
   [Brand, Christian Lehn] Novo Nordisk AS, Dept Insulin Pharmacol Histol & Delivery, Malov, Denmark.
C3 University of Southern Denmark; University of Copenhagen; Institut
   National de la Sante et de la Recherche Medicale (Inserm); Institut
   National des Sciences Appliquees de Lyon - INSA Lyon; INRAE; Universite
   Claude Bernard Lyon 1; CHU Lyon; University of Copenhagen; University of
   Copenhagen; Universite de Montpellier; Institut National de la Sante et
   de la Recherche Medicale (Inserm); Novo Nordisk
RP Ruzzin, J (corresponding author), NIFES, Natl Inst Nutr & Seafood Res, N-5817 Bergen, Norway.
EM jerome.ruzzin@nifes.no
RI Kjellevold, Marian/Q-6334-2019; Coll, Lluis/C-8567-2014; Lock,
   Erik-Jan/AAM-9766-2020; Ruzzin, Jerome/AAA-5826-2020; Madsen,
   Lise/JAC-6159-2023; Marstrand, Troels/C-7039-2011; Ma,
   Tao/HTQ-6381-2023; Ruzzin, Jerome/U-1688-2017; Madsen, Lise/C-6246-2012;
   Kjellevold, Marian/C-2973-2012; Kristiansen, Karsten/J-5148-2014; Sonne,
   Si Brask/A-4851-2012
OI Du, Zhen-Yu/0000-0001-6581-5313; Pesenti, Sandra/0000-0003-4037-208X;
   Petersen, Rasmus Koefoed/0009-0003-6889-4899; Ruzzin,
   Jerome/0000-0003-3676-8145; Fajas, Lluis/0000-0002-1283-9503; meugnier,
   emmanuelle/0000-0002-2291-7691; Lock, Erik-Jan/0000-0002-8157-5249;
   Brand, Christian Lehn/0000-0002-7355-4448; Marstrand,
   Troels/0000-0002-8290-223X; Madsen, Lise/0000-0003-4468-1947;
   Kjellevold, Marian/0000-0001-7070-5784; Kristiansen,
   Karsten/0000-0002-6024-0917; Sonne, Si Brask/0000-0003-3194-3805;
   Chavey, Carine/0000-0002-5267-5638; Ma, Tao/0000-0003-2570-9449
FU European Research Council; Research Council of Norway; Danish Natural
   Science Research Council; The Diabetes Association; Novo Nordisk
   Foundation
FX This work was supported by grants from the European Research Council,
   the Research Council of Norway, the Danish Natural Science Research
   Council, The Diabetes Association, and the Novo Nordisk
   Foundation.C.L.B., employed at Novo Nordisk (a leading manufacturer of
   insulin analogs and diabetes management care products), holds shares in
   the company, and contributed independently with the clamp studies. The
   Novo Nordisk Foundation supports basic science independently of the
   company interests of Novo Nordisk A/S. The remaining authors declare
   they have no competing financial interest.
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NR 59
TC 318
Z9 357
U1 0
U2 148
PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE
PI RES TRIANGLE PK
PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233,
   RES TRIANGLE PK, NC 27709-2233 USA
SN 0091-6765
EI 1552-9924
J9 ENVIRON HEALTH PERSP
JI Environ. Health Perspect.
PD APR
PY 2010
VL 118
IS 4
BP 465
EP 471
DI 10.1289/ehp.0901321
PG 7
WC Environmental Sciences; Public, Environmental & Occupational Health;
   Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health; Toxicology
GA 580NA
UT WOS:000276454800017
PM 20064776
OA Green Submitted, gold, Green Published
DA 2025-06-11
ER

PT J
AU Palmer, BW
   Shir, C
   Chang, H
   Mulvaney, M
   Hall, JMH
   Shu, IW
   Jin, H
   Lohr, JB
AF Palmer, Barton W.
   Shir, Catherine
   Chang, Hang
   Mulvaney, Mallory
   Hall, Joshua M. H.
   Shu, I-Wei
   Jin, Hua
   Lohr, James B.
TI Increased prevalence of metabolic syndrome in Veterans with PTSD
   untreated with antipsychotic medications
SO INTERNATIONAL JOURNAL OF MENTAL HEALTH
LA English
DT Article
DE Diabetes; cardiovascular; accelerated aging; obesity; hypertension;
   lipids
ID POSTTRAUMATIC-STRESS-DISORDER; CORONARY-HEART-DISEASE; AFFAIRS
   HEALTH-CARE; CARDIOVASCULAR-DISEASE; AFGHANISTAN VETERANS;
   INSULIN-RESISTANCE; UNITED-STATES; RISK; MORTALITY; TRENDS
AB Post-Traumatic Stress Disorder (PTSD) is not solely a psychiatric disorder; it also includes significant medical morbidity. Although there is evidence of increased risk of metabolic syndrome (MetS) in PTSD, the interpretation of previous studies is confounded by the inclusion of people on antipsychotic medications, which independently cause increased MetS. In this study, we investigated whether Veterans with PTSD not treated with antipsychotic medications (n = 115) demonstrate increased MetS compared to an age-comparable group of people from the U.S. National Health and Nutrition Examination Survey (NHNES; n = 1005). Using standardized criteria (abnormal values in 3 out of the 5 domains of obesity, hypertension, high density lipoprotein, triglyceride and fasting glucose concentrations) we compared the prevalence of MetS across groups. Relative to the NHNES group, a significantly higher proportion of the Veteran PTSD group met criteria for MetS (26.0% vs. 41.7%) with a higher proportion of abnormal values in four out of five MetS domains (excepting glucose). Our results suggest that the elevation of MetS associated with PTSD cannot be fully explained by iatrogenic effects of antipsychotic medication. We suggest that extra attention be devoted to the clinical management of metabolic risk factors for morbidity in patients with PTSD.
C1 [Palmer, Barton W.; Chang, Hang; Mulvaney, Mallory; Lohr, James B.] Vet Affairs San Diego Healthcare Syst, Ctr Excellence Stress & Mental Hlth, San Diego, CA USA.
   [Palmer, Barton W.; Jin, Hua] Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA.
   [Shir, Catherine] Univ Calif San Diego, Sch Med, La Jolla, CA 92093 USA.
   [Hall, Joshua M. H.; Shu, I-Wei; Jin, Hua; Lohr, James B.] Vet Affairs San Diego Healthcare Syst, Dept Psychiat, San Diego, CA USA.
   [Lohr, James B.] Univ Calif San Diego, Dept Neurosci, La Jolla, CA 92093 USA.
C3 US Department of Veterans Affairs; Veterans Health Administration (VHA);
   VA San Diego Healthcare System; University of California System;
   University of California San Diego; University of California System;
   University of California San Diego; US Department of Veterans Affairs;
   Veterans Health Administration (VHA); VA San Diego Healthcare System;
   University of California System; University of California San Diego
RP Jin, H; Lohr, JB (corresponding author), Univ Calif San Diego, VA San Diego Healthcare Syst, Dept Psychiat, 3350 La Jolla Village Dr MC-116A, San Diego, CA 92161 USA.
EM hjin@health.ucsd.edu; jlohr@ucsd.edu
RI Palmer, Barton/A-6030-2019; Hall, Joshua/AAP-7302-2020
OI Palmer, Barton/0000-0002-7618-3144
FU VA Merit Award [1I01 CX001351]; Department of Veterans Affairs
FX This study was supported, in part by VA Merit Award 1I01 CX001351, and
   the Department of Veterans Affairs.
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NR 61
TC 4
Z9 4
U1 0
U2 6
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 0020-7411
EI 1557-9328
J9 INT J MENT HEALTH
JI Int. J. Ment. Health
PD JAN 2
PY 2023
VL 52
IS 1
BP 45
EP 60
DI 10.1080/00207411.2021.1965398
EA AUG 2021
PG 16
WC Psychology, Clinical; Health Policy & Services; Psychiatry; Psychology
WE Emerging Sources Citation Index (ESCI)
SC Psychology; Health Care Sciences & Services; Psychiatry
GA 9X2XX
UT WOS:000688344600001
PM 34711996
OA Green Submitted, Green Accepted
DA 2025-06-11
ER

PT J
AU Higgins, S
   Smith, AN
   Williams, ER
   Das, BM
   Fedewa, MV
   Evans, EM
AF Higgins, Simon
   Smith, Alexandra N.
   Williams, Ewan R.
   Das, Bhibha M.
   Fedewa, Michael V.
   Evans, Ellen M.
TI Sex-specific correlates of metabolic syndrome risk in college-aged young
   adults
SO JOURNAL OF AMERICAN COLLEGE HEALTH
LA English
DT Article
DE Cardiometabolic risk; diet; lifestyle; physical activity; principal
   component analysis; sleep
AB Objective
   To identify the sex-specific prevalence of metabolic syndrome (MetS) risk factors and their physiological, psychosocial, and behavioral correlates in a college-aged population. Participants and methods: Cross-sectional assessment of MetS risk factors and potential correlates occurred in 379 first-year students (aged 18.34 +/- 0.49 years, 67.3% female). Multivariable linear regression assessed the relationships between potential correlates and continuous MetS risk scores, derived from principal component analysis. Results: MetS risk factors were present in 58.4% of females and 68.5% of males, with 2.4% and 3.2% having defined MetS. In females, percent body fat (beta = 0.46, p < 0.001), stress (beta = 0.12, p = 0.031), % kcal from sugar (beta = 0.18, p = 0.001), and moderate-to-vigorous physical activity (beta=-0.12, p = 0.036) were associated with risk score. Whereas, correlates in males included percent body fat (beta = 0.54, p < 0.001), C-reactive protein (beta = 0.15, p = 0.045), and AUDIT alcohol consumption score (beta = 0.15, p = 0.033). Conclusion: The sex-specific prevalence of MetS risk factors and correlates suggest that primary prevention strategies on college campuses should also follow a sex-specific approach.
C1 [Higgins, Simon; Smith, Alexandra N.] Elon Univ, Dept Exercise Sci, 2525 Campus Box, Elon, NC 27244 USA.
   [Williams, Ewan R.; Das, Bhibha M.; Fedewa, Michael V.; Evans, Ellen M.] Univ Georgia, Dept Kinesiol, Athens, GA 30602 USA.
   [Das, Bhibha M.] East Carolina Univ, Dept Kinesiol, Greenville, NC 27858 USA.
   [Fedewa, Michael V.] Univ Alabama, Dept Kinesiol, Tuscaloosa, AL USA.
C3 Elon University; University System of Georgia; University of Georgia;
   University of North Carolina; East Carolina University; University of
   Alabama System; University of Alabama Tuscaloosa
RP Higgins, S (corresponding author), Elon Univ, Dept Exercise Sci, 2525 Campus Box, Elon, NC 27244 USA.
EM shiggins8@elon.edu
RI Higgins, Simon/Q-9660-2019
OI Fedewa, Michael/0000-0002-2055-863X; Williams, Ewan/0000-0002-9113-3495;
   Higgins, Simon/0000-0001-8554-3116
FU U.S. Department of Agriculture [2008-55215-18825]
FX This study was supported by U.S. Department of Agriculture under Grant
   no. 2008-55215-18825 to EME. Data collection was performed by BMD, MVF,
   and EME. Review of literature and statistical analyses were performed by
   SH and ANS. Manuscript preparation and revision were performed by SH,
   ANS, BMD, ERW, MVF, and EME. Preparation of the final document for
   submission was performed by SH and ANS.
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NR 49
TC 2
Z9 3
U1 2
U2 3
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 0744-8481
EI 1940-3208
J9 J AM COLL HEALTH
JI J. Am. Coll. Health
PD NOV 17
PY 2022
VL 70
IS 8
BP 2527
EP 2534
DI 10.1080/07448481.2020.1869751
EA DEC 2020
PG 8
WC Education & Educational Research; Public, Environmental & Occupational
   Health
WE Social Science Citation Index (SSCI)
SC Education & Educational Research; Public, Environmental & Occupational
   Health
GA 6E2FO
UT WOS:000617589000001
PM 33577409
DA 2025-06-11
ER

PT J
AU Veigas, NM
   Dharmalingam, M
   Marcus, SR
AF Veigas, Nina Maria
   Dharmalingam, Mala
   Marcus, Sara Rani
TI OXIDATIVE STRESS IN OBESITY AND METABOLIC SYNDROME IN ASIAN INDIANS
SO JOURNAL OF MEDICAL BIOCHEMISTRY
LA English
DT Article
DE obesity; metabolic syndrome; oxidative stress; insulin resistance;
   hydroperoxides; cardiovascular disorders
ID TUMOR-NECROSIS-FACTOR; INSULIN-RESISTANCE; ABDOMINAL OBESITY;
   ADIPOSE-TISSUE; DYSFUNCTION; FAT; INFLAMMATION
AB Oxidative stress in associated with the individual components of metabolic syndrome and has been implicated in the development of complications of these metabolic disorders. In this study oxidative stress levels have been compared in obese Indians (a high-risk population for diabetes and cardiovascular disorders) with and without metabolic syndrome. 30 adult normotensive, normoglycemic obese subjects and 35 adults with metabolic syndrome of either sex with BMI >23 kg/m(2) were compared with 30 adult, health volunteers with BMI <23 kg/m(2). Anthropometric parameters, blood pressure, biochemical parameters, hydroperoxides levels and total antioxidant capacity were estimated. The obese groups with and without metabolic syndrome had significantly increased anthropometric parameters like waist circumference and index of central obesity and aqueous phase hydroperoxides when compared with normal controls. The metabolic syndrome group also had significantly increased blood sugar levels, lipid profile and hydroperoxide levels when compared to obese or control groups. There was no alteration in the total antioxidant capacity in any of the groups. The Triglyceride/HDL-Cholesterol ratio (>3), a surrogate marker of insulin resistance, indicates insulin resistance in the metabolic syndrome group. The anthropometric profile, insulin resistance and oxidative stress seen in obesity are further elaborated in metabolic syndrome. Thus, the early identification of high-risk individuals based on anthropometric parameters, lipid profile, insulin resistance and indices of oxidative stress may help to prevent the development of complications of metabolic syndrome.
C1 [Marcus, Sara Rani] MSU GEF Int Med Sch, Dept Biochem, MSRIT Post, Bangalore 560054, Karnataka, India.
   [Dharmalingam, Mala] MS Ramaiah Med Coll & Teaching Hosp, Dept Endocrinol, Bangalore, Karnataka, India.
RP Marcus, SR (corresponding author), MSU GEF Int Med Sch, Dept Biochem, MSRIT Post, Bangalore 560054, Karnataka, India.
EM sararanimarcus@yahoo.co.in
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   [Anonymous], The Asia-Pacific perspective: redefining obesity and its treatment
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NR 29
TC 6
Z9 6
U1 0
U2 2
PU SCIENDO
PI WARSAW
PA DE GRUYTER POLAND SP Z O O, BOGUMILA ZUGA 32A STR, 01-811 WARSAW, POLAND
SN 1452-8258
EI 1452-8266
J9 J MED BIOCHEM
JI J. Med. Biochem.
PY 2011
VL 30
IS 2
BP 115
EP 120
DI 10.2478/v10011-011-0006-6
PG 6
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 783KK
UT WOS:000292081000005
OA gold
DA 2025-06-11
ER

PT J
AU Virgen-Carrillo, CA
   de los Rios, DLH
   Torres, KR
   Moreno, AGM
AF Virgen-Carrillo, Carmen Alejandrina
   Rios, Diana Laura Hernandez de los
   Torres, Karina Ruiz
   Moreno, Alma Gabriela Martinez
TI Diagnostic Criteria for Metabolic Syndrome in Diet-Induced Rodent
   Models: A Systematic Review
SO CURRENT DIABETES REVIEWS
LA English
DT Review
DE Rats; reference value; metabolic alterations; high-fat diet;
   high-carbohydrate diet; cafeteria diet
ID HIGH-FAT DIET; CARDIOMETABOLIC RISK-FACTORS; HIGH-FRUCTOSE; RAT MODEL;
   HIGH-CARBOHYDRATE; INSULIN-RESISTANCE; OXIDATIVE STRESS; BLOOD-PRESSURE;
   CAFETERIA DIET; IMPROVES
AB Background: Thousands of publications in recent years have addressed the induction of metabolic syndrome (MetS) in rodents. However, the criteria and the reference values for diagnosing this disease have not been defined.
   Objective: Our main objective was to carry out a systematic review to gather evidence about the criteria for biochemical and anthropometric parameters in which scientific studies have relied on to report that rats developed MetS from a previous dietary manipulation.
   Methods: We compiled characteristics and findings of diet-induced MetS with high-fat, high-carbohydrate, high-fat/high-carbohydrates, and cafeteria diet from PubMed and Science Direct databases published in the last 5 years.
   Results: The results on the principal determinants for the syndrome, published in the reviewed articles, were chosen to propose reference values in the rat models of food induction.
   Conclusion: The values obtained will serve as reference cut-of points in the development of the disease; in addition, the compilation of data will be useful in planning and executing research protocols in animal models.
C1 [Virgen-Carrillo, Carmen Alejandrina; Rios, Diana Laura Hernandez de los; Torres, Karina Ruiz; Moreno, Alma Gabriela Martinez] Univ Guadalajara, Ctr Univ Sur, Inst Invest Comportamiento Alimentario & Nutr, Ave Enrique Arreola Silva 883,Bldg X3, Municipio De Zapotlan El 49000, Jalisco, Mexico.
C3 Universidad de Guadalajara
RP Virgen-Carrillo, CA (corresponding author), Univ Guadalajara, Ctr Univ Sur, Inst Invest Comportamiento Alimentario & Nutr, Ave Enrique Arreola Silva 883,Bldg X3, Municipio De Zapotlan El 49000, Jalisco, Mexico.
EM carmen.vir-gen@alumnos.udg.mx
OI Ruiz Torres, Karina/0000-0001-6896-8606; Virgen-Carrillo, Carmen
   Alejandrina/0000-0001-5430-8666; Martinez Moreno, Alma
   Gabriela/0000-0002-7495-1007
FU Consejo Nacional de Ciencia y Tecnologia, CONACyT, Mexico [733116]
FX Author C.A.V.-C. was supported by a scholarship (733116) from the
   Consejo Nacional de Ciencia y Tecnologia, CONACyT, Mexico.
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NR 234
TC 1
Z9 1
U1 1
U2 24
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1573-3998
EI 1875-6417
J9 CURR DIABETES REV
JI Curr. Diabetes Reviews
PY 2021
VL 17
IS 8
AR e140421192834
DI 10.2174/1573399817666210414103730
PG 26
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA WK2YA
UT WOS:000709595300006
PM 33855947
DA 2025-06-11
ER

PT J
AU Ros, E
   Tapsell, LC
   Sabaté, J
AF Ros, Emilio
   Tapsell, Linda C.
   Sabate, Joan
TI Nuts and Berries for Heart Health
SO CURRENT ATHEROSCLEROSIS REPORTS
LA English
DT Article
DE Tree nuts; Peanuts; Berries; Fatty acids; Phytochemicals; Antioxidants;
   Flavonoids; Healthy diets; Epidemiologic studies; Clinical trials;
   Coronary heart disease; Stroke; Obesity; Metabolic syndrome; Visceral
   adiposity; Type 2 diabetes; Weight gain; Hypertension; Blood
   cholesterol; Triglycerides; Glycemic control; Insulin; Oxidation;
   Inflammation; Flow-mediated dilatation
ID CARDIOVASCULAR RISK-FACTORS; CONTROLLED CROSSOVER TRIAL; METABOLIC
   SYNDROME; INSULIN-RESISTANCE; POSTPRANDIAL GLYCEMIA; INFLAMMATORY
   MARKERS; WALNUT CONSUMPTION; MEDITERRANEAN DIET; PHYSICIANS HEALTH;
   RANDOMIZED-TRIAL
AB Nuts are nutrient-dense foods with complex matrices rich in unsaturated fatty acids and other bioactive compounds, such as L-arginine, fiber, minerals, tocopherols, phytosterols, and polyphenols. By virtue of their unique composition, nuts are likely to beneficially impact heart health. Epidemiologic studies have associated nut consumption with a reduced incidence of coronary heart disease in both genders and diabetes in women. Limited evidence also suggests beneficial effects on hypertension and inflammation. Interventional studies consistently show that nut intake has a cholesterol-lowering effect and there is emerging evidence of beneficial effects on oxidative stress, inflammation, and vascular reactivity. Blood pressure, visceral adiposity, and glycemic control also appear to be positively influenced by frequent nut consumption without evidence of undue weight gain. Berries are another plant food rich in bioactive phytochemicals, particularly flavonoids, for which there is increasing evidence of benefits on cardiometabolic risk that are linked to their potent antioxidant power.
C1 [Ros, Emilio] Hosp Clin Barcelona, Inst Invest Biomed August Pi & Sunyer, Endocrinol & Nutr Serv, Lipid Clin, E-08036 Barcelona, Spain.
   [Ros, Emilio] Inst Salud Carlos III, Ciber Fisiopatol Obesidad Nutr CIBERobon, Madrid, Spain.
   [Tapsell, Linda C.] Univ Wollongong, Illawarra Hlth & Med Res Inst, Wollongong, NSW 2522, Australia.
   [Tapsell, Linda C.] Univ Wollongong, Smart Foods Ctr, Wollongong, NSW 2522, Australia.
   [Sabate, Joan] Loma Linda Univ, Sch Publ Hlth, Dept Nutr, Loma Linda, CA 92350 USA.
C3 University of Barcelona; Hospital Clinic de Barcelona; IDIBAPS;
   Instituto de Salud Carlos III; University of Wollongong; Illawarra
   Health & Medical Research Institute; University of Wollongong; Loma
   Linda University
RP Ros, E (corresponding author), Hosp Clin Barcelona, Inst Invest Biomed August Pi & Sunyer, Endocrinol & Nutr Serv, Lipid Clin, E-08036 Barcelona, Spain.
EM eros@clinic.ub.es; ltapsell@uow.edu.au; jsabate@llu.edu
OI Ros, Emilio/0000-0002-2573-1294; Tapsell, Linda/0000-0002-2546-6507;
   Sabate, Joan/0000-0002-9063-9785
FU Spanish Health Ministry (FIS Thematic Research Networks) [C03/01,
   G03/140]; California Walnut Commission, Sacramento, CA
FX Work supported in part by grants from the Spanish Health Ministry (FIS
   Thematic Research Networks C03/01 and G03/140) and the California Walnut
   Commission, Sacramento, CA. CIBERobn is an initiative of ISCIII, Spain.
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NR 60
TC 89
Z9 96
U1 0
U2 58
PU CURRENT MEDICINE GROUP
PI PHILADELPHIA
PA 400 MARKET STREET, STE 700, PHILADELPHIA, PA 19106 USA
SN 1523-3804
J9 CURR ATHEROSCLER REP
JI Curr. Atherosclerol. Rep.
PD NOV
PY 2010
VL 12
IS 6
BP 397
EP 406
DI 10.1007/s11883-010-0132-5
PG 10
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 652XW
UT WOS:000282046800006
PM 20820955
DA 2025-06-11
ER

PT J
AU Gentzel, M
AF Gentzel, Michael
TI Obesity, Metabolic Syndrome, and Sugar-Sweetened Beverages (SSBs) in
   America: A Novel Bioethical Argument for a Radical Public Health
   Proposal
SO JOURNAL OF BIOETHICAL INQUIRY
LA English
DT Article; Early Access
DE Public health; Obesity; Sugar-sweetened beverages; Bioethics; Cancer;
   Cardiovascular disease; Diabetes; Nutrition; Ethics and food;
   Epidemiology; Public health ethics
ID CORONARY-HEART-DISEASE; FRUCTOSE CORN SYRUP; DE-NOVO LIPOGENESIS;
   CARDIOMETABOLIC RISK-FACTORS; SOFT DRINK CONSUMPTION;
   ALCOHOL-CONSUMPTION; BLOOD-PRESSURE; CARDIOVASCULAR-DISEASE;
   INSULIN-RESISTANCE; DIETARY FRUCTOSE
AB The prevalence of obesity, metabolic syndrome, and the associated long-term chronic diseases (cardiovascular disease, type II diabetes, cancer, Alzheimer's disease, depression) have reached epidemic levels in the United States and Western nations. In response to this public health calamity, the author of this paper presents and defends a novel bioethical argument: the consistency argument for outlawing SSBs (sugar-sweetened beverages) for child consumption (the "consistency argument"). This argument's radical conclusion states that the government is justified in outlawing SSBs consumption for child consumption. The reasoning is as follows: if one accepts that the physical harm caused by chronic alcohol consumption justifies the government outlawing alcoholic beverages for child consumption, and there is strong evidence that comparable physical harms result from chronic SSBs consumption, then, mutatis mutandis, the government is also justified in outlawing child consumption of SSBs. To support this argument, the author provides extensive evidence based on epidemiological observational studies, interventional studies, controlled trials, large meta-analyses, and the pathophysiology and biological mechanisms of action behind SSBs and chronic disease. Chronic consumption of large doses of SSBs and alcoholic beverages both drive the same diseases: obesity and insulin resistance, cardiovascular disease, hypertension, and cancer. Chronic SSB consumption carries the additional risk of Alzheimer's disease, dementia, and depression. The author concludes this paper by considering prominent objections to the consistency argument, and then demonstrating that each objection is unsound.
EM Lalovareigns@aol.com
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NR 173
TC 1
Z9 1
U1 4
U2 7
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1176-7529
EI 1872-4353
J9 J BIOETHIC INQ
JI J. Bioethical Inq.
PD 2024 SEP 11
PY 2024
DI 10.1007/s11673-024-10369-5
EA SEP 2024
PG 19
WC Ethics; Medical Ethics; Social Issues; Social Sciences, Biomedical
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Social Sciences - Other Topics; Medical Ethics; Social Issues;
   Biomedical Social Sciences
GA F5D3X
UT WOS:001310018500001
PM 39259474
DA 2025-06-11
ER

PT J
AU Bhatia, LS
   Curzen, NP
   Calder, PC
   Byrne, CD
AF Bhatia, Lokpal S.
   Curzen, Nicholas P.
   Calder, Philip C.
   Byrne, Christopher D.
TI Non-alcoholic fatty liver disease: a new and important cardiovascular
   risk factor?
SO EUROPEAN HEART JOURNAL
LA English
DT Review
DE Non-alcoholic fatty liver disease; Cardiovascular disease; Insulin
   resistance; Risk factor; Ectopic fat
ID GAMMA-GLUTAMYL-TRANSFERASE; EPICARDIAL ADIPOSE-TISSUE; INTIMA-MEDIA
   THICKNESS; CORONARY-HEART-DISEASE; CAROTID-ARTERY INTIMA;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; HEPATIC STEATOSIS; ALANINE
   AMINOTRANSFERASE; TRIGLYCERIDE CONTENT
AB Non-alcoholic fatty liver disease (NAFLD) affects up to a third of the population worldwide and may confer increased cardiometabolic risk with consequent adverse cardiovascular outcomes independent of traditional cardiovascular risk factors and the metabolic syndrome. It is characterized almost universally by insulin resistance and is strongly associated with type 2 diabetes and obesity. Non-alcoholic fatty liver disease is a marker of pathological ectopic fat accumulation combined with a low-grade chronic inflammatory state. This results in several deleterious pathophysiological processes including abnormal glucose, fatty acid and lipoprotein metabolism, increased oxidative stress, deranged adipokine profile, hypercoaguability, endothelial dysfunction, and accelerated progression of atherosclerosis. This ultimately leads to a dysfunctional cardiometabolic phenotype with cardiovascular mortality representing the main mode of premature death in NAFLD. This review is aimed at introducing NAFLD to the clinical cardiologist by discussing in-depth the evidence to date linking NAFLD with cardiovascular disease, reviewing the likely mechanisms underlying this association, as well as summarizing from a cardiologists perspective, current and potential future treatment options for this increasingly prevalent disease.
C1 [Bhatia, Lokpal S.; Calder, Philip C.; Byrne, Christopher D.] Southampton Gen Hosp, Southampton Univ Hosp NHS Trust, Natl Inst Hlth Res Biomed Res Unit, Southampton SO16 6YD, Hants, England.
   [Bhatia, Lokpal S.; Curzen, Nicholas P.] Southampton Univ Hosp NHS Trust, Wessex Cardiothorac Unit, Southampton, Hants, England.
   [Bhatia, Lokpal S.; Curzen, Nicholas P.; Calder, Philip C.; Byrne, Christopher D.] Univ Southampton, Inst Dev Sci, Southampton, Hants, England.
C3 University of Southampton; University Hospital Southampton NHS
   Foundation Trust; University of Southampton; University Hospital
   Southampton NHS Foundation Trust; University of Southampton
RP Bhatia, LS (corresponding author), Southampton Gen Hosp, Southampton Univ Hosp NHS Trust, Natl Inst Hlth Res Biomed Res Unit, Level D S Acad Block,Tremona Rd, Southampton SO16 6YD, Hants, England.
EM loke.bhatia@soton.ac.uk
RI curzen, nick/AAD-8161-2020; Calder, Philip/E-9739-2013
OI Calder, Philip/0000-0002-6038-710X; Byrne, Christopher
   D/0000-0001-6322-7753; Curzen, Nick/0000-0001-9651-7829
FU Southampton NIHR Biomedical Research Unit in Nutrition, Lifestyle, and
   Obesity
FX L.S.B., P.C.C., and C.D.B. are all supported in part by the Southampton
   NIHR Biomedical Research Unit in Nutrition, Lifestyle, and Obesity.
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NR 147
TC 361
Z9 391
U1 0
U2 49
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0195-668X
EI 1522-9645
J9 EUR HEART J
JI Eur. Heart J.
PD MAY
PY 2012
VL 33
IS 10
BP 1190
EP +
DI 10.1093/eurheartj/ehr453
PG 14
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 944IY
UT WOS:000304194400012
PM 22408036
OA Bronze
DA 2025-06-11
ER

PT J
AU Knoff, AA
   Nowak, MK
   Van Etten, EJ
   Andreu-Arasa, VC
   Esterman, M
   Leritz, EC
   Fortenbaugh, FC
   Milberg, WP
   Fortier, CB
   Salat, DH
AF Knoff, Aubrey A.
   Nowak, Madeleine K.
   Van Etten, Emily J.
   Andreu-Arasa, V. Carlota
   Esterman, Michael
   Leritz, Elizabeth C.
   Fortenbaugh, Francesca C.
   Milberg, William P.
   Fortier, Catherine B.
   Salat, David H.
TI Metabolic syndrome is associated with reduced default mode network
   functional connectivity in young post-9/11 Veterans
SO BRAIN IMAGING AND BEHAVIOR
LA English
DT Article; Early Access
DE Metabolic syndrome; Functional magnetic resonance imaging; Veterans;
   Default mode; Functional connectivity
ID POSTTRAUMATIC-STRESS-DISORDER; HEALTHY OLDER-ADULTS; STATE BRAIN
   ACTIVITY; CARDIOVASCULAR-DISEASE; EPISODIC MEMORY; UNITED-STATES;
   MORTALITY; RISK; METAANALYSIS; CHOLESTEROL
AB Metabolic syndrome is a collection of health factors that increases risk for cardiovascular disease. A condition of aging, metabolic syndrome is associated with reduced brain network integrity, including functional connectivity alterations among the default mode, regions vulnerable to neurodegeneration. Prevalence of metabolic syndrome is elevated in younger populations including post-9/11 Veterans and individuals with posttraumatic stress disorder, but it is unclear whether metabolic syndrome affects brain function in earlier adulthood. Identifying early effects of metabolic syndrome on brain network integrity is critical, as these impacts could contribute to increased risk for cognitive disorders later in life for Veterans. The current study examined whether metabolic syndrome and its individual components were associated with default mode functional connectivity. We also explored the contribution of posttraumatic stress disorder and traumatic brain injury on these metabolic syndrome-brain relationships. Post-9/11 Veterans with combat deployment history (95 with and 325 without metabolic syndrome) underwent functional magnetic resonance imaging to capture seed-based resting-state functional connectivity within the default mode. The metabolic syndrome group demonstrated reduced positive functional connectivity between the posterior cingulate cortex seed and the bilateral superior frontal gyrus. Data-driven analyses demonstrated that metabolic syndrome components, particularly cholesterol and central adiposity, were associated with widespread reductions in default mode network connectivity. Functional connectivity was also reduced in participants with metabolic syndrome but without current posttraumatic stress disorder diagnosis and with traumatic brain injury history. These results suggest that metabolic syndrome disrupts resting-state functional connectivity decades earlier than prior work has shown.
C1 [Knoff, Aubrey A.; Nowak, Madeleine K.; Van Etten, Emily J.; Esterman, Michael; Fortenbaugh, Francesca C.; Milberg, William P.; Fortier, Catherine B.; Salat, David H.] VA Boston Healthcare Syst, Translat Res Ctr TBI & Stress Disorders TRACTS 182, 150 S Huntington Ave, Boston, MA 02130 USA.
   [Knoff, Aubrey A.; Van Etten, Emily J.; Leritz, Elizabeth C.; Fortenbaugh, Francesca C.; Milberg, William P.; Fortier, Catherine B.] Harvard Med Sch, Dept Psychiat, Boston, MA 02115 USA.
   [Knoff, Aubrey A.; Nowak, Madeleine K.; Van Etten, Emily J.; Esterman, Michael] Boston Univ, Chobanian & Avedisian Sch Med, Dept Psychiat, Boston, MA 02118 USA.
   [Nowak, Madeleine K.; Esterman, Michael] VA Boston Healthcare Syst, Natl Ctr PTSD, Boston, MA USA.
   [Leritz, Elizabeth C.; Milberg, William P.; Fortier, Catherine B.; Salat, David H.] VA Boston Healthcare Syst, Geriatr Res Educ & Clin Ctr GRECC, Boston, MA USA.
   [Andreu-Arasa, V. Carlota] VA Boston Healthcare Syst, Dept Radiol, Boston, MA USA.
   [Andreu-Arasa, V. Carlota] Boston Univ, Dept Radiol, Chobanian & Avedisian Sch Med, Boston, MA USA.
   [Esterman, Michael; Salat, David H.] VA Boston Healthcare Syst, Neuroimaging Res Vet Ctr, Boston, MA USA.
   [Salat, David H.] Anthinoula A Martinos Ctr Biomed Imaging, Boston, MA USA.
C3 Harvard University; Harvard University Medical Affiliates; US Department
   of Veterans Affairs; Veterans Health Administration (VHA); VA Boston
   Healthcare System; Harvard University; Harvard Medical School; Boston
   University; Harvard University; Harvard University Medical Affiliates;
   US Department of Veterans Affairs; Veterans Health Administration (VHA);
   VA Boston Healthcare System; Harvard University; Harvard University
   Medical Affiliates; US Department of Veterans Affairs; Veterans Health
   Administration (VHA); VA Boston Healthcare System; Geriatric Research
   Education & Clinical Center; Harvard University; Harvard University
   Medical Affiliates; US Department of Veterans Affairs; Veterans Health
   Administration (VHA); VA Boston Healthcare System; Boston University;
   Harvard University; Harvard University Medical Affiliates; US Department
   of Veterans Affairs; Veterans Health Administration (VHA); VA Boston
   Healthcare System
RP Knoff, AA (corresponding author), VA Boston Healthcare Syst, Translat Res Ctr TBI & Stress Disorders TRACTS 182, 150 S Huntington Ave, Boston, MA 02130 USA.; Knoff, AA (corresponding author), Harvard Med Sch, Dept Psychiat, Boston, MA 02115 USA.; Knoff, AA (corresponding author), Boston Univ, Chobanian & Avedisian Sch Med, Dept Psychiat, Boston, MA 02118 USA.
EM aubrey.knoff@va.gov
RI Fortier, Catherine/AAS-2163-2021; Van Etten, Emily/LRC-3140-2024
OI Van Etten, Emily/0000-0003-1587-2138; Knoff, Aubrey/0000-0002-0134-656X;
   Esterman, Michael/0000-0002-9000-3920
FU Translational Research Center for TBI and Stress Disorders (TRACTS), VA
   Rehabilitation Research and Development Traumatic Brain Injury National
   Network Research Center [B3001-C]; Rehabilitation Research and
   Development, Department of Veterans Affairs (CBF) [RX-002907]; National
   Institute of Mental Health (MKN) [T32MH019836]; Office of Academic
   Affiliations, U.S. Department of Veterans Affairs
FX This research was supported by the Translational Research Center for TBI
   and Stress Disorders (TRACTS), which is a VA Rehabilitation Research and
   Development Traumatic Brain Injury National Network Research Center
   (B3001-C), a Merit Review grant (RX-002907) from the Rehabilitation
   Research and Development, Department of Veterans Affairs (CBF), and a
   T32 award (T32MH019836) from the National Institute of Mental Health
   (MKN). This material is based upon work done as part of the
   Interprofessional Polytrauma and Traumatic Brain Injury Rehabilitation
   Research Fellowship supported by the Office of Academic Affiliations,
   U.S. Department of Veterans Affairs (AAK & EJVE). The contents of this
   manuscript do not represent the views of the U.S. Department of Veterans
   Affairs or the United States Government.
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NR 60
TC 0
Z9 0
U1 0
U2 1
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1931-7557
EI 1931-7565
J9 BRAIN IMAGING BEHAV
JI Brain Imaging Behav.
PD 2024 SEP 30
PY 2024
DI 10.1007/s11682-024-00927-1
EA SEP 2024
PG 10
WC Neuroimaging
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA H7T4Z
UT WOS:001325430500001
PM 39347938
DA 2025-06-11
ER

PT J
AU Larouche, E
   Hudon, C
   Goulet, S
AF Larouche, Eddy
   Hudon, Carol
   Goulet, Sonia
TI Potential benefits of mindfulness-based interventions in mild cognitive
   impairment and Alzheimer's disease: An interdisciplinary perspective
SO BEHAVIOURAL BRAIN RESEARCH
LA English
DT Article
DE Mild cognitive impairment; Alzheimer's disease; Mindfulness-based
   intervention; Stress; Depression; Metabolic syndrome
ID WHITE-MATTER LESIONS; QUALITY-OF-LIFE; LEUKOCYTE TELOMERE LENGTH;
   GROWTH-FACTOR EXPRESSION; CORPUS-CALLOSUM ATROPHY; VOXEL-BASED
   MORPHOMETRY; BREAST-CANCER PATIENTS; CENTRAL-NERVOUS-SYSTEM; STRESS
   REDUCTION MBSR; VASCULAR RISK-FACTORS
AB The present article is based on the premise that the risk of developing Alzheimer's disease (AD) from its prodromal phase (mild cognitive impairment; MCI) is higher when adverse factors (e.g., stress, depression, and metabolic syndrome) are present and accumulate. Such factors augment the likelihood of hippocampal damage central in MCI/AD aetiology, as well as compensatory mechanisms failure triggering a switch toward neurodegeneration. Because of the devastating consequences of AD, there is a need for early interventions that can delay, perhaps prevent, the transition from MCI to AD. We hypothesize that mindfulness-based interventions (MBI) show promise with regard to this goal. The present review discusses the associations between modifiable adverse factors and MCI/AD decline, MBI's impacts on adverse factors, and the mechanisms that could underlie the benefits of MBI. A schematic model is proposed to illustrate the course of neurodegeneration specific to MCI/AD, as well as the possible preventive mechanisms of MBI. Whereas regulation of glucocorticosteroids, inflammation, and serotonin could mediate MBI's effects on stress and depression, resolution of the metabolic syndrome might happen through a reduction of inflammation and white matter hyperintensities, and normalization of insulin and oxidation. The literature reviewed in this paper suggests that the main reach of MBI over MCI/AD development involves the management of stress, depressive symptoms, and inflammation. Future research must focus on achieving deeper understanding of MBI's mechanisms of action in the context of MCI and AD. This necessitates bridging the gap between neuroscientific subfields and a cross-domain integration between basic and clinical knowledge. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Larouche, Eddy; Hudon, Carol; Goulet, Sonia] Univ Laval, Ecole Psychol, CRIUSMQ, Quebec City, PQ G1J 2G3, Canada.
C3 Laval University
RP Goulet, S (corresponding author), Univ Laval, Ecole Psychol, CRIUSMQ, 2601 Canardiere F-2400, Quebec City, PQ G1J 2G3, Canada.
EM sonia.goulet@psy.ulaval.ca
OI Hudon, Carol/0000-0002-7554-3187
FU Fonds de recherche du Quebec - Sante [26809]
FX The authors wish to thank Modesto R. Peralta III for text editing. C.
   Hudon is supported by a salary award (Chercheur-boursier Senior; No.
   26809) from the Fonds de recherche du Quebec - Sante.
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NR 231
TC 60
Z9 70
U1 0
U2 89
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0166-4328
EI 1872-7549
J9 BEHAV BRAIN RES
JI Behav. Brain Res.
PD JAN 1
PY 2015
VL 276
SI SI
BP 199
EP 212
DI 10.1016/j.bbr.2014.05.058
PG 14
WC Behavioral Sciences; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Behavioral Sciences; Neurosciences & Neurology
GA AU2XP
UT WOS:000345478200022
PM 24893317
DA 2025-06-11
ER

PT J
AU Das, UN
AF Das, Undurti N.
TI Can essential fatty acids reduce the burden of disease(s)?
SO LIPIDS IN HEALTH AND DISEASE
LA English
DT Article
ID METABOLIC SYNDROME-X; C-REACTIVE PROTEIN; PLASMODIUM-FALCIPARUM;
   DELTA(5) DESATURASES; RISK; REPLICATION; ANTIBACTERIAL; HYPERTENSION;
   INHIBITION; EXPRESSION
AB Coronary heart disease, stroke, diabetes mellitus, hypertension, cancer, depression schizophrenia, Alzheimer's disease, and collagen vascular diseases are low-grade systemic inflammatory conditions that are a severe burden on health care resources. Essential fatty acids (EFAs) and their metabolites: eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), gamma-linolenic acid (GLA), dihomo-gamma-linolenic acid (DGLA), and arachidonic acid (AA) and their products: prostaglandin E-1, prostacyclin, lipoxins, resolvins, and protectins suppress inflammation, augment healing, and are of benefit in the prevention and management of these conditions. Hence, supplementation of EFAs could reduce burden of these disease(s).
C1 UND Life Sci, Shaker Hts, OH 44120 USA.
   ICTPH, Hyderabad 500016, Andhra Pradesh, India.
RP Das, UN (corresponding author), UND Life Sci, 13800 Fairhill Rd 321, Shaker Hts, OH 44120 USA.
EM undurti@hotmail.com
RI Das, Undurti/A-7918-2009
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EI 1476-511X
J9 LIPIDS HEALTH DIS
JI Lipids Health Dis.
PD MAR 18
PY 2008
VL 7
AR 9
DI 10.1186/1476-511X-7-9
PG 5
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA 282GK
UT WOS:000254555500002
PM 18348729
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Lunguleac, T
   Azoicai, D
   Manole, A
   Patrascu, A
   Moscalu, M
AF Lunguleac, Tiberiu
   Azoicai, Doina
   Manole, Alina
   Patrascu, Alexandru
   Moscalu, Mihaela
TI The Contribution of Stress Level in Modifying the Cardiometabolic Risk
   in a Population Cohort from North-East Romania
SO REVISTA DE CHIMIE
LA English
DT Article
DE cardiometabolic risk; psycho-behavioral factors; perceived stress scale
AB The cardiometabolic risk is used to assess the probability of developing a cardiovascular disease in association with diabetes. The research of stress factor represents a breakthrough in assessing this risk. The study aim was to evaluate the importance of cardiometabolic risk measurement instruments in the context of psycho-behavioral factors expressed by individual stress level. The cross-sectional study consisted of applying a PSL assessment questionnaire to a group of 254 individuals. Quantification of the PSL was achieved by a previously validated standardized questionnaire (PSS Scale). The research involved completing the questionnaire and corroborating clinical and paraclinical data (LDL-cholesterol, glycemia, glycosylatedhemoglobin - HbAlc). Data were analyzed using the SPSS V.21 software (IBM). The calculation of global cardiovascular risk score (SCORE) highlighted that 75% of cases presented a risk for a cardiovascular event over the next 10 years of lower than 3 (30%). Fasting glycemia values showed significant differences compared to glycosylated hemoglobin values (t(value )= 8.68, p<<0.01, 95% CI). It is noted the absence of significant differences between the calculated mean value and the normal LDL maximum threshold (t(value) = 0.96, p = 0.336). Mean values of females perceived stress score (M-PSS/female = 20.9 +/- 6.43SD) are significantly higher (F = 30.7, p <0.05, 95% CI) versus males (M-PSS/male = 16.5 +/- 5 .925D), but there is no correlation between patient's age and perceived stress score (r = 0.028, p = 0.651, 95% CI). Correlation of socio-economic factors with PSL reveals that low educational level (r = -0.203, p = 0.001) and low income (r = -0.204, p = 0.001) significantly increase the PSL. The results indicate that there is no correlation between perceived stress score and cardiovascular risk score (r = -0.0936, p = 0.137, 95% CI). Aspects revealed by study results highlight the need for monitoring stress factor in actions of clinical management in patients at high cardiometabolic risk.
C1 [Lunguleac, Tiberiu] Grigore T Popa Univ Med & Pharm, Fac Med, Thorac Surg Dept, 16 Univ Str, Iasi 700115, Romania.
   [Azoicai, Doina; Manole, Alina; Moscalu, Mihaela] Grigore T Popa Univ Med & Pharm, Fac Med, Epidemiol Dept, 16 Univ Str, Iasi 700115, Romania.
   Grigore T Popa Univ Med & Pharm, Fac Med, Med Informat & Biostat Dept, 16 Univ Str, Iasi 700115, Romania.
   [Patrascu, Alexandru] Grigore T Popa Univ Med & Pharm, Fac Med, Orthopaed Dept, 16 Univ Str, Iasi 700115, Romania.
C3 Grigore T Popa University of Medicine & Pharmacy; Grigore T Popa
   University of Medicine & Pharmacy; Grigore T Popa University of Medicine
   & Pharmacy; Grigore T Popa University of Medicine & Pharmacy
RP Azoicai, D (corresponding author), Grigore T Popa Univ Med & Pharm, Fac Med, Epidemiol Dept, 16 Univ Str, Iasi 700115, Romania.
EM doina.azoicai@gmail.com
RI Moscalu, Mihaela/ABA-9799-2020; Manole, Alina/ABE-8861-2021; Patrascu,
   Alexandru/AAB-7109-2020; AZOICAI, DOINA/HDO-6161-2022
OI AZOICAI, DOINA/0000-0003-0423-4085
CR ALDAGHRI NM, 2014, BMC PUBLIC HEALTH, V14, DOI DOI 10.1186/1471-2261-14-51
   BEKLEY E. T., 2006, DOC NEWS, V3, P1
   BERGMANN N. C., 2014, ENDOCR CONNECT
   COVEN S., 1983, J HEALTH SOC BEHAV, V24, P385
   de Vente W, 2015, BIOMED RES INT-UK, V2015, DOI 10.1155/2015/431725
   Després JP, 2008, EUR HEART J SUPPL, V10, pB1, DOI 10.1093/eurheartj/sum051
   Gallo LC, 2014, PSYCHOSOM MED, V76, P468, DOI 10.1097/PSY.0000000000000069
   Golbidi S, 2015, AM J PHYSIOL-HEART C, V308, pH1476, DOI 10.1152/ajpheart.00859.2014
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NR 16
TC 1
Z9 1
U1 0
U2 1
PU REVISTA CHIMIE SRL
PI BUCURESTI
PA CALES PLEVNEI NR 139A, SECTOR 6, BUCURESTI, ROMANIA
SN 0034-7752
J9 REV CHIM-BUCHAREST
JI Rev. Chim.
PD MAR
PY 2019
VL 70
IS 3
BP 1071
EP 1075
PG 5
WC Chemistry, Multidisciplinary; Engineering, Chemical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Engineering
GA HT9RZ
UT WOS:000464911600068
DA 2025-06-11
ER

PT J
AU Lee, D
   Lee, H
   Kim, SG
   Kim, KJ
   Jung, S
AF Lee, D. W.
   Lee, H. S.
   Kim, S. G.
   Kim, K. J.
   Jung, S. J.
TI The rocky road to freedom: number of countries transited during
   defection and risk of metabolic syndrome among North Korean Refugees in
   South Korea
SO PUBLIC HEALTH
LA English
DT Article
DE North Korean Refugees; Defection; Traumatic experience; Metabolic
   syndrome; Mental health; Physical health
ID POSTTRAUMATIC-STRESS-DISORDER; MENTAL-HEALTH; DEPRESSION; ASSOCIATION;
   CHOLESTEROL; COMPONENTS; DISEASE; ILLNESS; OBESITY
AB Objectives: North Korean Refugees (NKRs) undergo defection, and this has been shown to impact their current health status in South Korea. However, little is understood about how the defection process is related to metabolic syndrome (MetS). This study regarded the defection process to be a quasi measurement of traumatic experience and investigated whether defection was a risk factor for MetS among NKRs living in South Korea.Study design: This cross-sectional study obtained data from the Korea University Anam Hospital in Seoul. NKRs (N 1/4 847) voluntarily completed questionnaires and underwent at least one medical examination between October 2008 and July 2021.Methods: Multivariable logistic regression models were used to evaluate whether the number of countries transited by NKRs was associated with MetS by controlling for covariates.Results: The prevalence of MetS among male and female NKRs in South Korea was 12.3% and 13.3%, respectively. The highest prevalence of MetS (33.4%) was among NKRs who had transited two countries. The number of months in transit countries (mean: 49.9 & PLUSMN; 51.7) and period of residence in South Korea (mean: 40.9 & PLUSMN; 40.9 months) were also considered. NKRs who transited three countries had a higher probability of MetS (odds ratio [OR] 2.660, 95% confidence interval [CI] 1.161-6.097) than those who travelled directly to South Korea. NKRs who transited three countries and had only resided in South Korea for a short period had a higher probability of MetS (OR 3.424, 95% CI 1.149-10.208) than those who have lived in South Korea for a longer period.Conclusions: Considering the social vulnerability of NKRs and consequential health problems, there is an urgent need for appropriate support from the government and society.& COPY; 2023 The Authors. Published by Elsevier Ltd on behalf of The Royal Society for Public Health. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
C1 [Lee, D. W.; Jung, S. J.] Yonsei Univ, Dept Prevent Med, Coll Med, 50 Yonsei Ro, Seoul 03722, South Korea.
   [Lee, D. W.] Yonsei Univ, Inst Hlth Serv Res, Seoul 03722, South Korea.
   [Lee, H. S.] Res Investment Global Hlth Technol Fund Fdn, Seoul 03145, South Korea.
   [Kim, S. G.; Kim, K. J.] Korea Univ, Dept Internal Med, Div Endocrinol & Metab, Coll Med, 73 Goryeodae Ro, Seoul 02841, South Korea.
   [Kim, S. G.] Korea Univ, Dept Healthcare & Med Unified Korea, Coll Med, Seoul 02842, South Korea.
   [Jung, S. J.] Yonsei Univ, Grad Sch, Dept Publ Hlth, Seoul 03722, South Korea.
   [Jung, S. J.] Massachusetts Gen Hosp, Ctr Global Hlth, Boston, MA 02114 USA.
   [Jung, S. J.] Harvard Ctr Populat & Dev Studies, Cambridge, MA 02138 USA.
C3 Yonsei University; Yonsei University Health System; Yonsei University;
   Korea University; Korea University Medicine (KU Medicine); Korea
   University; Korea University Medicine (KU Medicine); Yonsei University;
   Harvard University; Harvard University Medical Affiliates; Massachusetts
   General Hospital; Harvard University; Harvard T.H. Chan School of Public
   Health
RP Jung, S (corresponding author), Yonsei Univ, Dept Prevent Med, Coll Med, 50 Yonsei Ro, Seoul 03722, South Korea.; Kim, KJ (corresponding author), Korea Univ, Dept Internal Med, Div Endocrinol & Metab, Coll Med, 73 Goryeodae Ro, Seoul 02841, South Korea.
EM jins0707@korea.ac.kr; sunjaejung@yuhs.ac
RI Jung, Sun Jae/GVU-7200-2022; Lee, Doo Woong/IAL-9314-2023; Kim, Sin
   Gon/KQU-7757-2024; Jung, Sun Jae/D-5620-2011
OI LEE, DOO WOONG/0000-0002-8843-2099; Kim, Sin Gon/0000-0002-7430-3675;
   Kim, Kyoung Jin/0000-0001-7925-2515; Jung, Sun Jae/0000-0002-5194-7339;
   Kim, Kyeong Jin/0000-0002-5878-6005
FU SongAm Memorial Research Fund through Yonsei University College of
   Medicine and National Research Foundation of Korea grant - Ministry of
   Science and ICT [2020R1C1C1003502]
FX S.J.J. and D.W.L are supported by the SongAm Memorial Research Fund
   (grant number is not applicable) through Yonsei University College of
   Medicine and National Research Foundation of Korea grant funded by the
   Ministry of Science and ICT (grant number 2020R1C1C1003502) .
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NR 42
TC 0
Z9 0
U1 1
U2 2
PU W B SAUNDERS CO LTD
PI LONDON
PA 32 JAMESTOWN RD, LONDON NW1 7BY, ENGLAND
SN 0033-3506
EI 1476-5616
J9 PUBLIC HEALTH
JI Public Health
PD AUG
PY 2023
VL 221
BP 208
EP 215
DI 10.1016/j.puhe.2023.06.019
EA JUL 2023
PG 8
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA P1LV7
UT WOS:001048334400001
PM 37490839
OA hybrid
DA 2025-06-11
ER

PT J
AU Magnavita, N
AF Magnavita, Nicola
TI Work-Related Psychological Injury Is Associated with Metabolic Syndrome
   Components in Apparently Healthy Workers
SO PLOS ONE
LA English
DT Article
ID POSTTRAUMATIC-STRESS-DISORDER; JOB STRAIN; PSYCHOSOCIAL FACTORS;
   CARDIOVASCULAR RISK; HYPERTENSION; JAPANESE; METAANALYSIS; POPULATION;
   DEPRESSION
AB Objective
   The aim of this study was to evaluate the association between psychological damage caused by common occupational trauma and metabolic syndrome (MES).
   Method
   571 workers from 20 small Italian companies were invited to fill in the Psychological Injury Risk Indicator (PIRI) during their routine medical examination at the workplace.
   Results
   Compared to workers with no psychological injury, workers with a high PIRI score had a significantly increased risk of having at least one metabolic syndrome component (adjusted hazards ratio, 1.8; 95% confidence interval, 1.2 to 2.6). There was a significant increase in the risk of hypertriglyceridemia in male workers (OR 2.53 CI95% 1.03-6.22), and of hypertension in female workers (OR 2.45 CI95% 1.29-4.66).
   Conclusion
   Psychological injury related to common occupational trauma may be a modifiable risk factor for metabolic syndrome.
C1 Univ Cattolica Sacro Cuore, Dept Publ Hlth, Rome, Italy.
C3 Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli
RP Magnavita, N (corresponding author), Univ Cattolica Sacro Cuore, Dept Publ Hlth, Rome, Italy.
EM nicolamagnavita@gmail.com
RI Magnavita, Nicola/J-6074-2014
FU Universita Cattolica del Sacro Cuore D1 funds
FX The author received no specific funding for this work. Publication fees
   will be paid with Universita Cattolica del Sacro Cuore D1 funds.
CR [Anonymous], 2006, The IDF consensus worldwide definition of the metabolic syndrome
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NR 37
TC 18
Z9 19
U1 0
U2 3
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JUN 18
PY 2015
VL 10
IS 6
AR e0130944
DI 10.1371/journal.pone.0130944
PG 10
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Science & Technology - Other Topics
GA CK9NT
UT WOS:000356567500139
PM 26086387
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Shiraishi, A
   Ikeda, H
   Haramaki, N
   Murohara, T
   Matsumoto, T
   Ueno, T
   Imaizumi, T
AF Shiraishi, A
   Ikeda, H
   Haramaki, N
   Murohara, T
   Matsumoto, T
   Ueno, T
   Imaizumi, T
TI Abnormal myocardial blood flow distribution in patients with angina
   pectoris and normal coronary arteriograms
SO JAPANESE CIRCULATION JOURNAL-ENGLISH EDITION
LA English
DT Article
DE angina pectoris; coronary arteries; myocardial blood flow distribution;
   myocardial contrast echocardiography
ID TWO-DIMENSIONAL ECHOCARDIOGRAPHY; LEFT-VENTRICULAR FUNCTION; CONTRAST
   ECHOCARDIOGRAPHY; SYNDROME-X; VASODILATOR RESERVE; CHEST PAIN;
   PERFUSION; ARTERIES; INFARCTION; OCCLUSION
AB To evaluate coronary microvascular function and its relation to the genesis of chest pain and ST-segment depression during exercise in patients with syndrome X, pacing-induced changes in transmural myocardial blood flow distribution were quantitatively assessed by 2-dimensional myocardial contrast echocardiography. Of 25 patients with a history of chest pain and normal coronary arteries with the negative ergonovine test, 11 had exercise-induced chest pain and ST-segment depression (syndrome X), and 14 did not (controls). Myocardial blood flow distribution before and after pacing stress was assessed by measuring the ratio of the endocardial to epicardial gray level (ie, endo/epi gray level ratio) in the territory of the left anterior descending coronary artery. Pacing induced chest pain and ST-segment depression were observed in syndrome X, but not in controls. The endo/epi gray level ratio in syndrome X significantly decreased after pacing (from 0.98+/-0.10 to 0.76+/-0.17, p<0.01), but not in controls (from 0.97+/-0.08 to 0.99+/-0.08, NS). Abnormal myocardial blood flow distribution may play an important role in exercise-induced chest pain and ST-segment depression in these patients.
C1 Kurume Univ, Sch Med, Dept Internal Med 3, Kurume, Fukuoka 8300011, Japan.
C3 Kurume University
RP Ikeda, H (corresponding author), Kurume Univ, Sch Med, Dept Internal Med 3, 67 Asahi Machi, Kurume, Fukuoka 8300011, Japan.
RI Murohara, Toyoaki/M-4958-2014
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NR 36
TC 3
Z9 5
U1 0
U2 1
PU BLACKWELL SCIENCE ASIA
PI CARLTON
PA 54 UNIVERSITY ST, P O BOX 378, CARLTON, VICTORIA 3053, AUSTRALIA
SN 0047-1828
J9 JPN CIRC J
JI Jpn. Circ. J.-Engl. Ed.
PD AUG
PY 2000
VL 64
IS 8
BP 566
EP 571
DI 10.1253/jcj.64.566
PG 6
WC History & Philosophy Of Science; Social Sciences, Biomedical; Peripheral
   Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC History & Philosophy of Science; Biomedical Social Sciences;
   Cardiovascular System & Cardiology
GA 339RF
UT WOS:000088491200006
PM 10952151
OA Bronze
DA 2025-06-11
ER

PT J
AU Di Majo, D
   Ricciardi, N
   Di Liberto, V
   Allegra, M
   Frinchi, M
   Urone, G
   Scordino, M
   Massaro, A
   Mudò, G
   Ferraro, G
   Sardo, P
   Giglia, G
   Gambino, G
AF Di Majo, Danila
   Ricciardi, Nicolo
   Di Liberto, Valentina
   Allegra, Mario
   Frinchi, Monica
   Urone, Giulia
   Scordino, Miriana
   Massaro, Alessandro
   Mudo, Giuseppa
   Ferraro, Giuseppe
   Sardo, Pierangelo
   Giglia, Giuseppe
   Gambino, Giuditta
TI The remarkable impact of Opuntia Ficus Indica fruit administration on
   metabolic syndrome: Correlations between cognitive functions, oxidative
   stress and lipid dysmetabolism in the high-fat, diet-fed rat model
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Article
DE Cognitive impairment; Leptin; Oxidative stress markers; Behaviour;
   Nutraceutical
ID BRAIN INSULIN-RESISTANCE; ANTIOXIDANT ACTIVITIES; MEMORY CONSOLIDATION;
   ALZHEIMERS-DISEASE; LEPTIN RESISTANCE; INDUCED OBESITY; WEIGHT-LOSS;
   MECHANISMS; DEPRESSION; IMPAIRMENT
AB Background: A wealth of evidence underscores the bioactive properties of nutraceuticals and functional foods in addressing oxyinflammatory-based diseases with implications at both peripheral and central levels. Opuntia ficus-indica (OFI) is well-documented for its health-promoting attributes, though its fruit (OFIF) remains relatively understudied. Not only poses Metabolic Syndrome (MetS) cardiometabolic risks but also contributes significantly to cognitive impairment, especially in crucial brain areas such as hippocampus and hypothalamus. Methods: Following 8 weeks of HFD to induce MetS, rats received OFIF oral supplementation for 4 weeks to evaluate cognitive and affective modifications using behavioural paradigms, i.e. open field, burrowing, whitedark box, novelty-suppressed feeding, and object recognition tests. Our investigation extended to biochemical evaluations of lipid homeostasis, central and peripheral oxidative stress and neurotrophic pathways, correlating these measures together with circulating leptin levels. Results: Our data revealed that OFIF modulation of leptin positively correlates with systemic and brain oxidative stress, with markers of increased anxiety-like behaviour and impaired lipid homeostasis. On the other hand, leptin levels reduced by OFIF are associated with improved antioxidant barriers, declarative memory and neurotrophic signalling. Discussion: This study underscores OFIF neuroactive potential in the context of MetS-associated cognitive impairment, offering insights into its mechanisms and implications for future therapeutic strategies.
C1 [Di Majo, Danila; Ricciardi, Nicolo; Di Liberto, Valentina; Frinchi, Monica; Urone, Giulia; Scordino, Miriana; Mudo, Giuseppa; Ferraro, Giuseppe; Sardo, Pierangelo; Giglia, Giuseppe; Gambino, Giuditta] Univ Palermo, Sch Med, Dept Biomed Neurosci & Adv Diagnost, Sect Human Physiol, I-90127 Palermo, Italy.
   [Di Majo, Danila; Allegra, Mario; Ferraro, Giuseppe; Sardo, Pierangelo; Giglia, Giuseppe; Gambino, Giuditta] Univ Palermo, Postgrad Sch Nutr & Food Sci, Sch Med, I-90127 Palermo, Italy.
   [Allegra, Mario; Massaro, Alessandro] Univ Palermo, Dept Biol Chem & Pharmaceut Sci & Technol STEBICEF, Viale Sci, I-90128 Palermo, Italy.
C3 University of Palermo; University of Palermo; University of Palermo
RP Giglia, G (corresponding author), Univ Palermo, Dept Biomed Neurosci & Adv Diagnost, Sect Human Physiol, corso Tukory 129, I-90127 Palermo, Italy.
EM giuseppe.giglia@unipa.it
RI Mudò, Giuseppa/G-7408-2011; Di Majo, Danila/A-9078-2015; Massaro,
   Alessandro/LXV-4682-2024; Di+Liberto, Valentina/ACL-0264-2022; Allegra,
   Mario/AAG-3256-2019; Giglia, Giuseppe/M-7100-2016
OI Frinchi, Monica/0000-0002-1061-5725; Massaro,
   Alessandro/0009-0001-6182-8608; Urone, Giulia/0009-0000-3130-2202;
   Mudo', Giuseppa/0000-0002-3275-9981; DI MAJO, Danila/0000-0002-0533-6932
FU University of Palermo; INCENTIVI AD ATTIVITA' DI RICERCA
   INTERDISCIPLINARE [1105/2023, 135120/2023]
FX This work was supported partly via funds "FFR 2023" provided to Dr.
   Gambino and Dr. Di Majo by University of Palermo and partly with funds
   "INCENTIVI AD ATTIVITA' DI RICERCA INTERDISCIPLINARE" (Rep.Numb.:
   1105/2023, Prot.Numb.:135120/2023) provided to Prof. Giuseppe Giglia by
   University of Palermo.
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NR 123
TC 4
Z9 4
U1 1
U2 2
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD AUG
PY 2024
VL 177
AR 117028
DI 10.1016/j.biopha.2024.117028
EA JUL 2024
PG 15
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA XU3N6
UT WOS:001264152700001
PM 38959603
OA gold
DA 2025-06-11
ER

PT J
AU Oliveira, J
   Paixa, V
   Cardoso, G
   Xavier, M
   Almeida, JMCD
   Oliveira-Maia, AJ
AF Oliveira, Jose
   Paixa, Vitor
   Cardoso, Graca
   Xavier, Miguel
   Almeida, Jose Miguel Caldas de
   Oliveira-Maia, Albino J.
TI Childhood adversities and the comorbidity between mood and general
   medical disorders in adults: Results from the WHO World Mental Health
   Survey Portugal
SO BRAIN, BEHAVIOR, & IMMUNITY - HEALTH
LA English
DT Article
DE Childhood adversity; Mood disorders; General medical disorders;
   Arthritis; In flammation
ID EARLY-LIFE ADVERSITY; SYSTEMIC INFLAMMATION; METABOLIC SYNDROME; CHRONIC
   PAIN; ALL-CAUSE; ASSOCIATION; DEPRESSION; ONSET; STRESS; EXPERIENCES
AB Objective: Childhood adversities have been linked to poor health outcomes in adults, including both mood and general medical disorders. Here we tested the hypothesis that childhood adversities specifically increase the risk of comorbidity between mood and general medical disorders, rather than increasing the risk of either one independently. Methods: Mood disorders (DSM-IV major depressive, dysthymic and bipolar disorders), childhood adversities and general medical disorders were assessed in 2060 adults in the WHO World Mental Health Survey Portugal. Discrete-time survival analyses were used to investigate the association between mood disorders and subsequent first-onset general medical disorders and between general medical disorders and subsequent first-onset mood disorders, in adults. Discrete-time survival and multinomial regression analyses were used to test the influence of childhood adversities on the comorbidity between mood disorders and general medical disorders. Anxiety disorders were used as a psychiatric control. Results: Adult-onset mood disorders were found to precede the onset of diabetes (OR:1.8; 95% CI:1.2-2.9), arthritis (OR:1.6; 95% CI:1.1-2.3) and seasonal allergies (OR:1.6; 95% CI:1.1-2.5) while adult-onset hypertension was found to precede the onset of mood disorders (OR:1.7; 95% CI:1.2-2.6). Maladaptive family functioning (abuse, neglect and parental maladjustment), was associated with mood disorders (OR:1.5; 95% CI:1.2-1.9), hypertension (OR:1.4; 95% CI:1.1-1.7), arthritis (OR:1.3; 95% CI:1.0-1.6) and seasonal allergies (OR:1.5; 95% CI:1.1-2.0) in adulthood. Finally, the effect of maladaptive family functioning in predicting comorbid mood disorders and arthritis significantly differed from its effect in predicting only arthritis (p 1/4 0.01), which was not observed for other comorbidities. Maladaptive family functioning further predicted comorbid anxiety disorders and hypertension. Conclusion: Childhood adversities may be a specific risk factor for comorbid mood disorders and arthritis in adults.
C1 [Oliveira, Jose; Oliveira-Maia, Albino J.] Univ Nova Lisboa, NOVA Med Sch, NMS, Lisbon, Portugal.
   [Oliveira, Jose; Oliveira-Maia, Albino J.] Champalimaud Ctr Unknown, Champalimaud Clin Ctr, Lisbon, Portugal.
   [Oliveira, Jose; Paixa, Vitor; Oliveira-Maia, Albino J.] Champalimaud Ctr Unknown, Champalimaud Res, Lisbon, Portugal.
   [Oliveira, Jose] Ctr Hosp Psiquiatr Lisboa, Reabilitacao, Lisbon, Portugal.
   [Cardoso, Graca; Xavier, Miguel; Almeida, Jose Miguel Caldas de] Univ NOVA Lisboa, NOVA Med Sch, CHRC, Lisbon, Portugal.
   [Cardoso, Graca; Almeida, Jose Miguel Caldas de] Lisbon Inst Global Mental Hlth, Lisbon, Portugal.
   [Xavier, Miguel] Univ Nova Lisboa, NOVA Med Sch, Dept Mental Hlth, Lisbon, Portugal.
   [Oliveira-Maia, Albino J.] Ctr Hosp Lisboa Ocidental, Dept Psychiat & Mental Hlth, Lisbon, Portugal.
   [Oliveira-Maia, Albino J.] Champalimaud Ctr Unknown, Champalimaud Clin Ctr, Ave Brasilia, P-1400038 Lisbon, Portugal.
C3 Universidade Nova de Lisboa; Fundacao Champalimaud; Fundacao
   Champalimaud; Universidade de Lisboa; Universidade Nova de Lisboa;
   Universidade Nova de Lisboa; Universidade de Lisboa; Centro Hospitalar
   de Lisboa Ocidental, EPE; Fundacao Champalimaud
RP Oliveira-Maia, AJ (corresponding author), Univ Nova Lisboa, NOVA Med Sch, NMS, Lisbon, Portugal.; Oliveira-Maia, AJ (corresponding author), Champalimaud Ctr Unknown, Champalimaud Clin Ctr, Lisbon, Portugal.; Oliveira-Maia, AJ (corresponding author), Champalimaud Ctr Unknown, Champalimaud Res, Lisbon, Portugal.; Oliveira-Maia, AJ (corresponding author), Champalimaud Ctr Unknown, Champalimaud Clin Ctr, Ave Brasilia, P-1400038 Lisbon, Portugal.
EM albino.maia@neuro.fchampalimaud.org
RI Oliveira, José/P-8459-2019; Oliveira-Maia, Albino Jorge/B-7976-2009
OI caldas de almeida, jose miguel/0000-0003-1902-6772; Oliveira,
   Jose/0000-0003-3475-4794; Oliveira-Maia, Albino
   Jorge/0000-0001-5071-3007; Cardoso, Graca/0000-0003-1756-0197; Xavier,
   Miguel/0000-0003-2698-1284; Paixao, Vitor/0000-0003-3722-0747
FU Champalimaud Foundation; Gulbenkian Foundation; Foundation for Science
   and Technology (FCT); Ministry of Health; National Institute of Mental
   Health (NIMH) [R01MH070884]; John D. and Catherine T. MacArthur
   Foundation; Pfizer Foundation; U.S. Public Health Service [R13-MH066849,
   R01-MH069864, R01 DA016558]; Fogarty International Center (FIRCA)
   [R03-TW006481]; Pan American Health Organization; Eli Lilly and Company;
   Ortho-McNeil Pharmaceutical; GlaxoSmithKline; Bristol-Myers Squibb;
   NARSAD 2018 Young Investigator Grant [27,595]; Fundacao para a Ciencia e
   Tecnologia (FCT) grant [PTDC/MED-NEU/31,331/2017]; European Commision
   Horizon 2020 grant
   [H2020-SC1-DTH-2018-2020_H2020-SC1-DTH-2019-875358-FAITH]
FX The WHO World Mental Health Survey Portugal was carried out by the
   Department of Mental Health, NOVA Medical School, NOVA University of
   Lisbon, with collaboration of the CESOP-Portuguese Catholic University
   and was funded by the Champalimaud Foundation, the Gulbenkian
   Foundation, the Foundation for Science and Technology (FCT) and the
   Ministry of Health. TheWHO World Mental Health Survey Portugal was
   carried out in conjunction with the World Health Organization WMH Survey
   Initiative which is supported by the National Institute of Mental Health
   (NIMH; R01MH070884), the John D. and Catherine T. MacArthur Foundation,
   the Pfizer Foundation, the U.S. Public Health Service (R13-MH066849,
   R01-MH069864 and R01 DA016558), the Fogarty International Center (FIRCA
   R03-TW006481), the Pan American Health Organization, Eli Lilly and
   Company, Ortho-McNeil Pharmaceutical, GlaxoSmithKline and Bristol-Myers
   Squibb. This study was supported by a NARSAD 2018 Young Investigator
   Grant (ID: 27,595) awarded to J.O. and a Fundacao para a Ciencia e
   Tecnologia (FCT) grant (PTDC/MED-NEU/31,331/2017) and a European
   Commision Horizon 2020 grant
   (H2020-SC1-DTH-2018-2020_H2020-SC1-DTH-2019-875358-FAITH) awarded to
   A.J.O.-M. Funding sources had no role in study design, data collection,
   analysis, interpretation of data, writing of the manuscript and decision
   to submit the paper for publication.
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NR 65
TC 3
Z9 3
U1 0
U2 2
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2666-3546
J9 BRAIN BEHAV IMMUN-HL
JI Brain Behav. Immun.-Health
PD NOV
PY 2021
VL 17
AR 100329
DI 10.1016/j.bbih.2021.100329
PG 8
WC Immunology; Neurosciences; Psychiatry
WE Emerging Sources Citation Index (ESCI)
SC Immunology; Neurosciences & Neurology; Psychiatry
GA R2SN8
UT WOS:001062900800002
PM 34589816
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Kaner, G
   Soylu, M
   Yüksel, N
   Inanç, N
   Ongan, D
   Basmisirli, E
AF Kaner, Gulsah
   Soylu, Meltem
   Yuksel, Nimet
   Inanc, Neriman
   Ongan, Dilek
   Basmisirli, Eda
TI Evaluation of Nutritional Status of Patients with Depression
SO BIOMED RESEARCH INTERNATIONAL
LA English
DT Article
ID 3RD NATIONAL-HEALTH; INSULIN-RESISTANCE; FISH CONSUMPTION; METABOLIC
   SYNDROME; ABDOMINAL OBESITY; MAJOR DEPRESSION; NUTRIENT INTAKE;
   OLDER-ADULTS; DIET QUALITY; FATTY-ACIDS
AB Aims and Objectives. Our goal was to determine nutritional status, body composition, and biochemical parameters of patients diagnosed with depression based on DSM-IV-TR criteria. Methods. A total of 59 individuals, aged 18-60 years admitted to Mental Health Centre of Kayseri Education and Research Hospital, were included in the study. The participants were randomly assigned to two groups; depression group (n = 29) and control group (n = 30). Anthropometric measurements, some biochemical parameters, demographic data, and 24-hour dietary recall were evaluated. Results. 65.5% of depression and 60.0% of control group were female. Intake of vitamins A, thiamine, riboflavin, B6, folate, C, Na, K, Mg, Ca, P, Fe, Zn, and fibre (P < 0.05) were lower in depression group. Median levels of body weight, waist circumference, hip circumference, waist-to-hip ratio (P < 0.05) were significantly higher in depression group. Fasting blood glucose levels, serum vitamins B12, and folic acid (P < 0.05) in depression group were lower than controls. Serum insulin and HOMA levels of two groups were similar. Conclusion. Some vitamin B consumption and serum vitamin B12 and folic acid levels were low while signs of abdominal obesity were high among patients with depression. Future research exploring nutritional status of individuals with depression is warranted.
C1 [Kaner, Gulsah; Soylu, Meltem; Inanc, Neriman; Basmisirli, Eda] Nuh Naci Yazgan Univ, Fac Hlth Sci, Dept Nutr & Dietet, TR-38170 Kayseri, Turkey.
   [Yuksel, Nimet] Kayseri Educ & Res Hosp, TR-38170 Kayseri, Turkey.
   [Ongan, Dilek] Izmir Katip Celebi Univ, Fac Hlth Sci, Dept Nutr & Dietet, TR-35620 Izmir, Turkey.
C3 Nuh Naci Yazgan University; Kayseri Training & Research Hospital; Izmir
   Katip Celebi University
RP Kaner, G (corresponding author), Nuh Naci Yazgan Univ, Fac Hlth Sci, Dept Nutr & Dietet, TR-38170 Kayseri, Turkey.
EM dytgulsahk@gmail.com
RI ONGAN, Dilek/AAP-6269-2021; soylu, meltem/R-4881-2018; Kaner Tohtak,
   Gulsah/HJA-3408-2022
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NR 77
TC 41
Z9 45
U1 0
U2 25
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2314-6133
EI 2314-6141
J9 BIOMED RES INT
JI Biomed Res. Int.
PY 2015
VL 2015
AR 521481
DI 10.1155/2015/521481
PG 9
WC Biotechnology & Applied Microbiology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Biotechnology & Applied Microbiology; Research & Experimental Medicine
GA CQ6SY
UT WOS:000360735500001
PM 26413529
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Orlic, L
   Mikolasevic, I
   Bagic, Z
   Racki, S
   Stimac, D
   Milic, S
AF Orlic, L.
   Mikolasevic, I.
   Bagic, Z.
   Racki, S.
   Stimac, D.
   Milic, S.
TI Chronic Kidney Disease and Nonalcoholic Fatty Liver Disease-Is There a
   Link?
SO GASTROENTEROLOGY RESEARCH AND PRACTICE
LA English
DT Review
ID 3RD NATIONAL-HEALTH; METABOLIC SYNDROME; INSULIN-RESISTANCE;
   CARDIOVASCULAR-DISEASE; RISK-FACTORS; MORTALITY; MICROALBUMINURIA;
   EPIDEMIOLOGY; ASSOCIATION; PREVALENCE
AB Research in recent years has led to the recognition of the importance of nonalcoholic fatty liver disease (NAFLD) and its relationship to the metabolic syndrome (MS). This has led to a growing interest in the potential prognostic value of NAFLD for adverse cardiovascular disease (CVD) outcome. On the other hand, searching for new risk factors for chronic kidney disease (CKD) development and progression is very important. Growing evidence suggests that the MS is an important factor in the pathogenesis of CKD. The best confirmation of this pathogenic link is hypertensive and diabetic nephropathy as the main causes of CKD. Furthermore, the possible link between NAFLD and CKD has also attracted research interest and recent data suggest an association between these two conditions. These findings have fuelled concerns that NAFLD may be a new and added risk factor for the development and progression of CKD. NAFLD and CKD share some important cardiometabolic risk factors and possible common pathophysiological mechanisms, and both are linked to an increased risk of incident CVD events. Therefore, common factors underlying the pathogenesis of NAFLD and CKD may be insulin resistance, oxidative stress, activation of rennin-angiotensin system, and inappropriate secretion of inflammatory cytokines by steatotic and inflamed liver.
C1 [Orlic, L.; Mikolasevic, I.; Racki, S.] Univ Hosp Ctr Rijeka, Dept Nephrol & Dialysis, Div Internal Med, Rijeka 51000, Croatia.
   [Bagic, Z.; Stimac, D.; Milic, S.] Univ Hosp Ctr Rijeka, Dept Gastroenterol, Div Internal Med, Rijeka 51000, Croatia.
C3 University of Rijeka; University of Rijeka
RP Orlic, L (corresponding author), Univ Hosp Ctr Rijeka, Dept Nephrol & Dialysis, Div Internal Med, Rijeka 51000, Croatia.
EM lidija.orlic@ri.t-com.hr
RI Štimac, Davor/ABF-7086-2020; Stimac, Davor/S-7420-2018; Sandra,
   Milic/S-5858-2018
OI Stimac, Davor/0000-0001-8243-2453; Sandra, Milic/0000-0002-6635-5360;
   Stimac, Davor/0009-0006-0015-4183
CR Armstrong MJ., 2013, Hepatology
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NR 40
TC 44
Z9 47
U1 0
U2 2
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1687-6121
EI 1687-630X
J9 GASTROENT RES PRACT
JI Gastroenterol. Res. Pract.
PY 2014
VL 2014
AR 847539
DI 10.1155/2014/847539
PG 6
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA AD0AZ
UT WOS:000332897500001
PM 24729784
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Victorio, JA
   Davel, AP
AF Victorio, Jamaira A.
   Davel, Ana P.
TI Perivascular Adipose Tissue Oxidative Stress on the Pathophysiology of
   Cardiometabolic Diseases
SO CURRENT HYPERTENSION REVIEWS
LA English
DT Review
DE Perivascular adipose tissue (PVAT); oxidative stress; vascular
   dysfunction; cardiometabolic risk factors; reactive oxygen species
   (ROS); cardiometabolic diseases
ID NITRIC-OXIDE SYNTHASE; REACTIVE OXYGEN; VASCULAR DYSFUNCTION; NADPH
   OXIDASE; ENDOTHELIAL DYSFUNCTION; OBESITY; FAT; ADIPONECTIN;
   ATHEROSCLEROSIS; ALDOSTERONE
AB Most of the systemic blood vessels are surrounded by the perivascular adipose tissue (PVAT). Healthy PVAT is anticontractile and anti-inflammatory, but a dysfunctional PVAT has been suggested to link cardiometabolic risk factors to vascular dysfunction. Vascular oxidative stress is an important pathophysiological event in cardiometabolic complications of obesity, type 2 diabetes, and hypertension. PVAT-derived adipocytes generate reactive oxygen species (ROS) including superoxide anion and hydrogen peroxide that might signal to the vascular wall. Therefore, an abnormal generation of ROS by PVAT emerges as a potential pathophysiological mechanism underlying vascular injury. This review summarizes new findings describing ROS production in the PVAT of several vascular beds, major sources of ROS in this tissue including mitochondria, NADPH oxidase and eNOS uncoupled, and finally, changes in ROS production affecting vascular function in the presence of cardiometabolic risk factors and diseases.
C1 [Victorio, Jamaira A.; Davel, Ana P.] Univ Estadual Campinas, Inst Biol, Dept Struct & Funct Biol, Campinas, SP, Brazil.
C3 Universidade Estadual de Campinas; Universidade de Sao Paulo
RP Davel, AP (corresponding author), Univ Estadual Campinas, UNICAMP, Inst Biol, Dept Struct & Funct Biol, POB 6109, BR-13083865 Sao Paulo, SP, Brazil.
EM anadavel@unicamp.br
RI Davel, Ana/L-8801-2013; Victorio, Jamaira Aparecida/R-7049-2018
OI Davel, Ana/0000-0002-9862-4262; Victorio, Jamaira
   Aparecida/0000-0002-0686-5844
FU Sao Paulo Research Foundation-FAPESP [2018/00543-8, 2018/16505-8];
   Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
   [18/16505-8, 18/00543-8] Funding Source: FAPESP
FX This work was supported by Sao Paulo Research Foundation-FAPESP (grants
   2018/00543-8 and 2018/16505-8).
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NR 82
TC 20
Z9 22
U1 0
U2 8
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1573-4021
EI 1875-6506
J9 CURR HYPERTENS REV
JI Curr. Hypertens. Rev.
PY 2021
VL 16
IS 3
BP 192
EP 200
DI 10.2174/1573402115666190410153634
PG 9
WC Peripheral Vascular Disease
WE Emerging Sources Citation Index (ESCI)
SC Cardiovascular System & Cardiology
GA PT4IA
UT WOS:000608577600005
PM 30968777
DA 2025-06-11
ER

PT J
AU Saboya, PP
   Bodanese, LC
   Zimmermann, PR
   Gustavo, AD
   Macagnan, FE
   Feoli, AP
   Oliveira, MD
AF Saboya, Patricia Pozas
   Bodanese, Luiz Carlos
   Zimmermann, Paulo Roberto
   Gustavo, Andreia da Silva
   Macagnan, Fabricio Edler
   Feoli, Ana Pandolfo
   Oliveira, Margareth da Silva
TI Lifestyle Intervention on Metabolic Syndrome and its Impact on Quality
   of Life: A Randomized Controlled Trial
SO ARQUIVOS BRASILEIROS DE CARDIOLOGIA
LA English
DT Article
DE Metabolic Syndrome; Life Style; Quality of Life; Cardiovascular
   Diseases; Prevention; Risk Factors
ID RISK-FACTORS; CARDIOVASCULAR RISK; PRIMARY-CARE; HEALTH-CARE;
   WEIGHT-LOSS; US ADULTS; DEPRESSION; DIET; ASSOCIATIONS; ANXIETY
AB Background: Lifestyle intervention programs can reduce the prevalence of metabolic syndrome (MetS) and, therefore, reduce the risk for cardiac disease, one of the main public health problems nowadays.
   Objective: The aim of this study was to compare the effects of three types of approach for lifestyle change programs in the reduction of metabolic parameters, and to identify its impact on the quality of life (QOL) of individuals with MetS.
   Methods: A randomized controlled trial included 72 individuals with MetS aged 30-59 years. Individuals were randomized into three groups of multidisciplinary intervention [Standard Intervention (SI) - control group; Group Intervention (GI); and Individual Intervention (II)] during 12 weeks. The primary outcome was change in the metabolic parameters, and secondarily, the improvement in QOL measures at three moments: baseline, 3 and 9 months.
   Results: Group and individual interventions resulted in a significant reduction in body mass index, waist circumference, systolic blood pressure at 3 months and the improvement of QOL, although it was significantly associated with the physical functioning domain. However, these changes did not remain 6 months after the end of intervention. Depression and anxiety were significantly associated with worse QOL, although they showed no effect on the response to intervention.
   Conclusion: Multidisciplinary intervention, especially in a group, might be an effective and economically feasible strategy in the control of metabolic parameters of MetS and improvement of QOL compared to SI, even in a dose-effect relationship.
C1 [Macagnan, Fabricio Edler] Univ Fed Ciencias Saude Porto Alegre UFCSPA, Porto Alegre, RS, Brazil.
   [Saboya, Patricia Pozas; Bodanese, Luiz Carlos; Zimmermann, Paulo Roberto; Gustavo, Andreia da Silva; Feoli, Ana Pandolfo; Oliveira, Margareth da Silva] Pontificia Univ Catolica Rio Grande Sul PUCRS, Porto Alegre, RS, Brazil.
C3 Universidade Federal de Ciencias da Saude de Porto Alegre; Pontificia
   Universidade Catolica Do Rio Grande Do Sul
RP Saboya, PP (corresponding author), Av Ipiranga 6690-300, BR-90610000 Jardim Bot, RS, Brazil.
EM patricia.saboya@acad.pucrs.br
RI Feoli, Ana/A-1748-2015; Macagnan, Fabrício/AAP-5564-2021; da Silva
   Oliveira, Margareth/K-9670-2015
OI da Silva Oliveira, Margareth/0000-0002-6490-5170
FU CNPq
FX This study was funded by CNPq.
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NR 35
TC 41
Z9 46
U1 0
U2 2
PU ARQUIVOS BRASILEIROS CARDIOLOGIA
PI RIO DE JANEIRO
PA AVENIDA MARECHAL CAMARA 160-330 CENTRO, RIO DE JANEIRO, RJ 20 020-907,
   BRAZIL
SN 0066-782X
J9 ARQ BRAS CARDIOL
JI Arq. Bras. Cardiol.
PD JAN
PY 2017
VL 108
IS 1
BP 60
EP 68
DI 10.5935/abc.20160186
PG 9
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA EK7ZD
UT WOS:000394142800009
PM 27982160
OA Green Submitted, gold, Green Published
DA 2025-06-11
ER

PT J
AU Hamer, M
   Malan, NT
   Harvey, BH
   Malan, L
AF Hamer, Mark
   Malan, Nico T.
   Harvey, Brian H.
   Malan, Leone
TI Depressive symptoms and sub-clinical atherosclerosis in Africans: Role
   of metabolic syndrome, inflammation and sympathoadrenal function
SO PHYSIOLOGY & BEHAVIOR
LA English
DT Article
DE Black Africans; Depression; Carotid intima media thickness; Metabolic
   syndrome; Inflammation
ID INTIMA-MEDIA THICKNESS; CORONARY-ARTERY CALCIFICATION; MIDDLE-AGED
   WOMEN; HEART-DISEASE; CARDIOVASCULAR RISK; CAROTID ATHEROSCLEROSIS;
   MAJOR DEPRESSION; LATE-LIFE; STRESS; EVENTS
AB Depressive symptoms have been consistently associated with sub-clinical atherosclerosis and future risk of coronary heart disease events. However, the pathways linking depression and coronary atherosclerosis are poorly understood. These types of data are particularly sparse in sub-Saharan Africa, which is presently experiencing an exponential rise in CVD. We examined the association between depressive symptoms and mean carotid intima media thickness (mCIMT), and the extent to which this association could be explained by sympathoadrenal function, inflammatory, and metabolic pathways. A sample of 186 black (aged 44.0 +/- 8.0 years) and 203 Caucasians (aged 44.8 +/- 10.8 years) were recruited as part of the Sympathetic Activity and Ambulatory Blood Pressure in Africans (SABPA) study - presently the only study in sub-Saharan Africa focusing on the contribution of the psychosocial risk factors to cardiovascular health. Depressive symptoms were assessed using the self administered 9-item Patient Health Questionnaire. After adjusting for age, sex, ethnicity, and anti-hypertensive drugs use, participants with severe depressive symptoms had higher mCIMT in comparison to participants with no symptoms (beta = 0.038 mm, 95% CI, 0.001 to 0.074 mm). Metabolic syndrome was the only significant mediator of the association between depressive symptoms and mCIMT, and accounted for approximately 21% of the effect. In summary, depressive symptoms were associated with an excess burden of sub-clinical vascular disease. Treatment of metabolic syndrome in patients with depression may partly reduce the risk of sub-clinical vascular disease development. (C) 2011 Elsevier Inc. All rights reserved.
C1 [Hamer, Mark] UCL, Dept Epidemiol & Publ Hlth, London WC1E 6BT, England.
   [Malan, Nico T.; Malan, Leone] North West Univ, Sch Physiol Nutr & Consumer Sci, HART, Potchefstroom, South Africa.
   [Harvey, Brian H.] North West Univ, Sch Pharm, Div Pharmacol, Unit Drug Res & Dev, Potchefstroom, South Africa.
C3 University of London; University College London; North West University -
   South Africa; North West University - South Africa
RP Hamer, M (corresponding author), UCL, Dept Epidemiol & Publ Hlth, 1-19 Torrington Pl, London WC1E 6BT, England.
EM m.hamer@ucl.ac.uk
RI Malan, Leone/Q-8187-2019; Malan, Leone/D-7203-2014; Hamer,
   Mark/C-1602-2008
OI Malan, Leone/0000-0003-3187-2410; Harvey, Brian/0000-0002-9864-7894;
   Hamer, Mark/0000-0002-8726-7992
FU HART (North-West University); National Research Foundation South Africa;
   Metabolic Syndrome Institute, France; British Heart Foundation, UK
FX HART (North-West University) and National Research Foundation South
   Africa, Metabolic Syndrome Institute, France. Dr Hamer is supported by
   the British Heart Foundation, UK. The funding organizations played no
   role in the design and conduct of the study; collection, management,
   analysis, and interpretation of the data; and preparation, review, or
   approval of the manuscript.
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NR 46
TC 9
Z9 12
U1 0
U2 12
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0031-9384
J9 PHYSIOL BEHAV
JI Physiol. Behav.
PD OCT 24
PY 2011
VL 104
IS 5
BP 744
EP 748
DI 10.1016/j.physbeh.2011.07.024
PG 5
WC Psychology, Biological; Behavioral Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Behavioral Sciences
GA 837MP
UT WOS:000296208200013
PM 21821058
DA 2025-06-11
ER

PT J
AU Tyrka, AR
   Walters, OC
   Price, LH
   Anderson, GM
   Carpenter, LL
AF Tyrka, A. R.
   Walters, O. C.
   Price, L. H.
   Anderson, G. M.
   Carpenter, L. L.
TI Altered Response to Neuroendocrine Challenge Linked to Indices of the
   Metabolic Syndrome in Healthy Adults
SO HORMONE AND METABOLIC RESEARCH
LA English
DT Article
DE metabolic syndrome; HPA axis; cortisol; ACTH; corticotrophin-releasing
   hormone
ID CORTICOTROPIN-RELEASING HORMONE; PITUITARY-ADRENAL AXIS; BODY-FAT
   DISTRIBUTION; CORTISOL SECRETION; INSULIN-RESISTANCE; ABDOMINAL OBESITY;
   PSYCHOSOCIAL STRESS; NERVOUS-SYSTEM; MEN; WOMEN
AB Metabolic syndrome (MetS) is characterized by central obesity, hypertension, insulin resistance, and hypercholesterolemia. Hypothalamicpituitary-adrenal (HPA) axis activity is frequently abnormal in MetS, and excessive cortisol exposure may be implicated in metabolic derangements. We investigated the hypothesis that cortisol and adrenocorticotropic hormone (ACTH) responses to a standardized neuroendocrine challenge test would be associated with indices of MetS in a community sample of healthy adults. Healthy adults, 125 men and 170 women, without significant medical problems or chronic medications were recruited from the community. Participants completed the dexamethasone/corticotropin-releasing hormone (Dex/CRH) test, and anthropometric measurements, blood pressure, glycosylated hemoglobin (HbA1c), and cholesterol were measured. Participants reported on their history of early life stress and recent stress, as well as mood and anxiety symptoms. Cortisol and ACTH responses to the Dex/CRH test were negatively associated with measures of central adiposity (p < 0.001) and blood pressure (p < 0.01), and positively associated with HDL cholesterol (p < 0.01). These findings remained significant after controlling for body mass index (BMI). Measures of stress and anxiety and depressive symptoms were negatively correlated with cortisol and ACTH responses in the Dex/CRH test but were not related to MetS indices. That altered HPA axis function is linked to MetS components even in a healthy community sample suggests that these processes may be involved in the pathogenesis of MetS. Identification of premorbid risk processes might allow for detection and intervention prior to the development of disease.
C1 [Tyrka, A. R.; Walters, O. C.; Price, L. H.; Carpenter, L. L.] Butler Hosp, Mood Disorders Res Program, Providence, RI 02906 USA.
   [Tyrka, A. R.; Walters, O. C.; Price, L. H.; Carpenter, L. L.] Butler Hosp, Lab Clin Neurosci, Providence, RI 02906 USA.
   [Tyrka, A. R.; Price, L. H.; Carpenter, L. L.] Brown Univ, Dept Psychiat & Human Behav, Warren Alpert Med Sch, Providence, RI 02912 USA.
   [Anderson, G. M.] Yale Univ, Sch Med, Yale Child Study Ctr, New Haven, CT USA.
C3 Butler Hospital Rhode Island; Butler Hospital Rhode Island; Brown
   University; Yale University
RP Tyrka, AR (corresponding author), Butler Hosp, Mood Disorders Res Program, 345 Blackstone Blvd, Providence, RI 02906 USA.
EM Audrey_Tyrka@Brown.edu
RI Tyrka, Audrey/L-2504-2014
OI Tyrka, Audrey/0000-0003-4653-1651; Walters, Oakland
   C./0000-0002-0597-8994
FU  [K23 MH067947];  [R01 MH068767]
FX Funding for this study was provided by K23 MH067947 (ART) and R01
   MH068767 (LLC).
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NR 47
TC 19
Z9 21
U1 0
U2 5
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0018-5043
EI 1439-4286
J9 HORM METAB RES
JI Horm. Metab. Res.
PD JUN
PY 2012
VL 44
IS 7
BP 543
EP 549
DI 10.1055/s-0032-1306342
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 959CG
UT WOS:000305287500010
PM 22549400
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Faraji, S
   Alizadeh, M
AF Faraji, Samira
   Alizadeh, Mohammad
TI Mechanistic Effects of Vitamin D Supplementation on Metabolic Syndrome
   Components in Patients with or without Vitamin D Deficiency
SO JOURNAL OF OBESITY & METABOLIC SYNDROME
LA English
DT Review
DE Metabolic syndrome; Vitamin D; Obesity; Hypertension
ID CARDIOMETABOLIC RISK-FACTORS; INSULIN-RESISTANCE; OXIDATIVE STRESS;
   POSTPRANDIAL LIPEMIA; ADIPOSE-TISSUE; BLOOD-PRESSURE; LIPID PROFILE;
   OBESITY; WOMEN; SERUM
AB The prevalences of metabolic syndrome (MetS) and vitamin D deficiency are increasing dramatically worldwide. MetS is a major challenge because it can increase the risk of most non-communicable diseases. The beneficial effect of vitamin D on MetS components remains controversial, so the present review focused on the clinical effects of vitamin D supplementation on MetS components. Vitamin D can inhibit the protein expression of nuclear factor beta; improve arterial stiffness; decrease renin-angiotensin-aldosterone system activity, parathyroid hormone levels, inflammatory cytokines, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, and lanosterol 14 alpha-demethylase enzyme activity; increase the activity of lipoprotein lipase; alter gene expression in C2C12 cells; and improve phospholipid metabolism and mitochondrial oxidation. We tried to elucidate and analyze almost all evidence from randomized controlled trial studies of the efficacy of vitamin D supplementation in patients with MetS. The findings of the present study reported beneficial effects of vitamin D supplementation on mentioned factors. Vitamin D supplementation is recommended in people with vitamin D deficiency even if it has no considerable effect on most MetS factors. However, existing data from interventional studies are insufficient to reach a definitive conclusion about the effect of vitamin D supplementation on MetS components in patients without vitamin D deficiency. Thus, new clinical studies are needed to test the hypothesis that vitamin D supplementation could alleviate MetS components in patients with sufficient intake of vitamin D.
C1 [Faraji, Samira] Urmia Univ Med Sci, Student Res Comm, Orumiyeh, Iran.
   [Faraji, Samira; Alizadeh, Mohammad] Urmia Univ Med Sci, Sch Med, Dept Nutr, Orumiyeh 5756115111, Iran.
   [Alizadeh, Mohammad] Urmia Univ Med Sci, Food & Beverages Safety Res Ctr, Orumiyeh 5756115111, Iran.
C3 Urmia University of Medical Sciences; Urmia University of Medical
   Sciences; Urmia University of Medical Sciences
RP Alizadeh, M (corresponding author), Urmia Univ Med Sci, Sch Med, Dept Nutr, Orumiyeh 5756115111, Iran.; Alizadeh, M (corresponding author), Urmia Univ Med Sci, Food & Beverages Safety Res Ctr, Orumiyeh 5756115111, Iran.
EM alizadeh.m@umsu.ac.ir
RI Alizadeh, Mohammad/M-5833-2017
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NR 84
TC 14
Z9 14
U1 0
U2 5
PU KOREAN SOC STUDY OBESITY
PI SEOUL
PA RENAISSANCE TOWER, 1010  14 MALLIJAE-RO, MAPO-GU, SEOUL, 04195, SOUTH
   KOREA
SN 2508-6235
EI 2508-7576
J9 J OBES METAB SYNDR
JI J. Obes. Metab. Syndr.
PD DEC
PY 2020
VL 29
IS 4
BP 270
EP 280
DI 10.7570/jomes20003
PG 11
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA PO6EA
UT WOS:000605260700005
PM 32747610
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Alidjanov, J
   Wolf, J
   Schuppe, HC
   Weidner, W
   Diemer, T
   Linn, T
   Halefeldt, I
   Wagenlehner, F
   Wiltink, J
   Pilatz, A
AF Alidjanov, J.
   Wolf, J.
   Schuppe, H. -C.
   Weidner, W.
   Diemer, T.
   Linn, T.
   Halefeldt, I.
   Wagenlehner, F.
   Wiltink, J.
   Pilatz, A.
TI Validation of the German version of the 'Hypogonadism Related Symptom
   Scale' (HRS) in andrological patients with infertility, HIV infection
   and metabolic syndrome
SO ANDROLOGIA
LA English
DT Article
DE Andrology; hypogonadism; metabolic syndrome; questionnaires; validation
ID ERECTILE FUNCTION IIEF; FORM HEALTH SURVEY; INTERNATIONAL INDEX; SERUM
   TESTOSTERONE; ANDROGEN DEFICIENCY; HOSPITAL ANXIETY; MEN; DYSFUNCTION;
   DEPRESSION; CONSTRUCTION
AB As commonly used self-reported screening instruments for male hypogonadism demonstrated lack of specificity, a Hypogonadism Related Symptom Scale (HRS) was developed in 2009 as a novel self-rating screening tool. As the questionnaire has not been validated, the purpose of our study was to perform a validation in patients presenting with different disorders (e.g. infertility, HIV infection or metabolic syndrome) and disease-related risk to develop hypogonadism. Two hundred and eighteen patients aged 19-71years (40.1 +/- 9.5) who completed the HRS and other common questionnaires [International Index Of Erectile Function (IIEF), National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI), Hospital Anxiety and Depression Scale (HADS), short form (SF)-12] were included. In all patients, blood levels of total testosterone, luteinizing hormone, follicle-stimulating hormone, oestradiol and sex hormone-binding globulin were determined and free testosterone was calculated. Cronbach's for the scale was 0.896, split-half 0.871 for the 1st half and 0.807 for the 2nd half. Spearman-Brown coefficient was 0.767, and Guttman split-half coefficient was 0.759. Consistent correlations were found between HRS and IIEF5 (=0.57, P<0.001), and HADS (=-0.6, P<0.001). In addition, HRS was significantly correlated with total testosterone (=0.135, P<0.05), free testosterone (=0.148, P<0.05) and oestradiol (=-0.134, P<0.05). Our validation study confirms the data from the initial development of the HRS questionnaire. Clinicians might have an additional advantage from the HRS when investigating males with suspected hypogonadism.
C1 [Alidjanov, J.; Wolf, J.; Schuppe, H. -C.; Weidner, W.; Diemer, T.; Halefeldt, I.; Wagenlehner, F.; Pilatz, A.] Univ Giessen, Dept Urol Pediat Urol & Androl, D-35392 Giessen, Germany.
   [Alidjanov, J.] Republican Specialized Ctr Urol, Outpatient Dept, Tashkent, Uzbekistan.
   [Linn, T.] Univ Giessen, Clin Res Unit, Med Clin & Policlin 3, D-35392 Giessen, Germany.
   [Wiltink, J.] Johannes Gutenberg Univ Mainz, Univ Med Ctr, Dept Psychosomat Med & Psychotherapy, D-55122 Mainz, Germany.
C3 Justus Liebig University Giessen; Justus Liebig University Giessen;
   Johannes Gutenberg University of Mainz
RP Alidjanov, J (corresponding author), Univ Giessen, Dept Urol Pediat Urol & Androl, Rudolf Buchheim Str 7, D-35392 Giessen, Germany.
EM dr.alidjanov@gmail.com
RI Alidjanov, Jakhongir/D-6116-2014
OI Alidjanov, Jakhongir/0000-0003-2531-4877
FU LOEWE focus group MIBIE (state government of Hessen, Germany) [B1, B2,
   B4]; European Association of Urology (EAU)
FX This work was supported by the LOEWE focus group MIBIE (Male Infertility
   during Infection and Inflammation, projects B1, B2 and B4, state
   government of Hessen, Germany) and a 3-month grant of the European
   Urological Scholarship Programme (EUSP) of the European Association of
   Urology (EAU). None of those who provided funds had a role in the study
   design, data collection and analysis, decision to publish or preparation
   of the manuscript.
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NR 45
TC 2
Z9 2
U1 0
U2 8
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0303-4569
EI 1439-0272
J9 ANDROLOGIA
JI Andrologia
PD DEC
PY 2014
VL 46
IS 10
BP 1189
EP 1197
DI 10.1111/and.12215
PG 9
WC Andrology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism
GA AT4MQ
UT WOS:000344913900016
PM 24387031
OA gold
DA 2025-06-11
ER

PT J
AU Ionescu-Tîrgoviste, C
AF Ionescu-Tirgoviste, C.
TI INSULIN RESISTANCE - WHAT IS MYTH AND WHAT IS REALITY?
SO ACTA ENDOCRINOLOGICA-BUCHAREST
LA English
DT Article
DE Insulin resistance sensitivity; insulin receptor; type 2 diabetes;
   obesity
ID BETA-CELL FUNCTION; TYPE-2 DIABETES-MELLITUS; RECEPTOR SUBSTRATE-1 GENE;
   GENOME-WIDE ASSOCIATION; METABOLIC-SYNDROME; QUANTITATIVE ESTIMATION;
   SERINE PHOSPHORYLATION; CONSENSUS SESSION; GLUCOSE; SENSITIVITY
AB Diabetes mellitus is a complex disorder of the energy metabolism of the human body. In the last WHO/ADA classification, the main forms of this disease are Type 1 (T1DM) and Type 2 (T2DM) diabetes mellitus. According to the same classification, the pathogenesis of T2DM is considered to include a progressive insulin secretory defect on the background of insulin resistance. Recently, controversies surround the concept of peripheral insulin resistance emerging in the 70's as an attempt to explain the differences from the T1DM phenotype whose autoimmune nature was as that time revealed. The insulin resistance hypothesis was based on the supposition that high plasma insulin levels are the result of a primary molecular defect against which the normal beta cells will react with an increased insulin secretion. This hypothesis has been used to explain both the pathogenesis of T2DM and the metabolic syndrome, named also for a short period of time "the insulin resistance syndrome". We will try to argue that what it is attributed to peripheral insulin resistance belongs in fact to obesity. Special emphasis is put on the role of the adipocytes, including the secretion of different adipokines with the secondary lipotoxicity, oxidative stress and pro-inflammatory reaction, explaining the complex relationship between obesity and diabetes.
C1 [Ionescu-Tirgoviste, C.] NC Paulescu Natl Inst Diabet Nutr & Metab Dis, Bucharest 020475, Romania.
RP Ionescu-Tîrgoviste, C (corresponding author), NC Paulescu Natl Inst Diabet Nutr & Metab Dis, I Movila Str 5-7, Bucharest 020475, Romania.
EM cit@paulescu.ro
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NR 122
TC 15
Z9 16
U1 1
U2 11
PU EDITURA ACAD ROMANE
PI BUCURESTI
PA CALEA 13 SEPTEMBRIE NR 13, SECTOR 5, BUCURESTI 050711, ROMANIA
SN 1841-0987
EI 1843-066X
J9 ACTA ENDOCRINOL-BUCH
JI Acta Endocrinol.
PD JAN-MAR
PY 2011
VL 7
IS 1
BP 123
EP 145
DI 10.4183/aeb.2011.123
PG 23
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 743HA
UT WOS:000289007600015
DA 2025-06-11
ER

PT J
AU Hein, M
   Lanquart, JP
   Loas, G
   Hubain, P
   Linkowski, P
AF Hein, Matthieu
   Lanquart, Jean-Pol
   Loas, Gwenole
   Hubain, Philippe
   Linkowski, Paul
TI Prevalence and risk factors of moderate to severe obstructive sleep
   apnea syndrome in major depression: a observational and retrospective
   study on 703 subjects
SO BMC PULMONARY MEDICINE
LA English
DT Article
DE Major depression; Obstructive apnea syndrome; Prevalence; Risk factors
ID C-REACTIVE PROTEIN; POSITIVE AIRWAY PRESSURE; METABOLIC SYNDROME;
   DAYTIME SLEEPINESS; METAANALYSIS; ANXIETY; PREDICTORS; DISORDER;
   EPIDEMIOLOGY; DIAGNOSIS
AB Background: Several studies have investigated the prevalence and risk factors of depression in subjects with obstructive sleep apnea syndrome. However, few studies have investigated the prevalence and risk factors for obstructive sleep apnea syndrome in major depression. The aim of this study was to examine the prevalence and risk factors of moderate to severe obstructive sleep apnea syndrome in a large sample of individuals with major depression.
   Methods: Data from 703 individuals with major depression recruited from the research database of the sleep laboratory of the Erasme Hospital were analysed. An apnea-hypopnea index of >= 15 events per hour was used as cut-off score for moderate to severe obstructive sleep apnea syndrome. Logistic regression analyses were conducted to examine clinical and demographic risk factors of moderate to severe obstructive sleep apnea syndrome in major depression.
   Results: The prevalence of moderate to severe obstructive sleep apnea syndrome in major depression is 13.94%. Multivariate logistic regression analysis revealed that male gender, snoring, excessive daytime sleepiness, lower insomnia complaint, presence of metabolic syndrome, age >= 50 years, BMI >30 kg/m(2), ferritin >300 mu g/L, CRP >7 mg/L and duration of sleep >= 8 h were significant risk factors of moderate to severe obstructive sleep apnea syndrome in major depression.
   Conclusion: Moderate to severe obstructive sleep apnea syndrome is a common pathology in major depression. The identification of these different risk factors advances a new perspective for more effective screening of moderate to severe obstructive sleep apnea syndrome in major depression.
C1 [Hein, Matthieu; Lanquart, Jean-Pol; Loas, Gwenole; Hubain, Philippe; Linkowski, Paul] Univ Libre Bruxelles, Erasme Hosp, Dept Psychiat & Sleep Lab, Route Lennik 808, B-1070 Brussels, Belgium.
C3 Universite Libre de Bruxelles
RP Hein, M (corresponding author), Univ Libre Bruxelles, Erasme Hosp, Dept Psychiat & Sleep Lab, Route Lennik 808, B-1070 Brussels, Belgium.
EM matthieu.hein@erasme.ulb.ac.be
RI Hein, Matthieu/IVV-2577-2023
OI Hein, Matthieu/0000-0003-4243-1653
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NR 61
TC 25
Z9 26
U1 0
U2 23
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1471-2466
J9 BMC PULM MED
JI BMC Pulm. Med.
PD DEC 4
PY 2017
VL 17
AR 165
DI 10.1186/s12890-017-0522-3
PG 10
WC Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Respiratory System
GA FP3UP
UT WOS:000417543800002
PM 29202829
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Gawlik-Kotelnicka, O
   Margulska, A
   Pleska, K
   Skowronska, A
   Strzelecki, D
AF Gawlik-Kotelnicka, Oliwia
   Margulska, Aleksandra
   Pleska, Kacper
   Skowronska, Anna
   Strzelecki, Dominik
TI Metabolic Status Influences Probiotic Efficacy for Depression-PRO-DEMET
   Randomized Clinical Trial Results
SO NUTRIENTS
LA English
DT Article
DE depression; abdominal obesity; metabolic syndrome; probiotics; anxiety;
   stress
ID TO-LYMPHOCYTE RATIO; CONSENSUS STATEMENT; DISORDER; METAANALYSIS; INDEX
AB Probiotics may represent a safe and easy-to-use treatment option for depression or its metabolic comorbidities. However, it is not known whether metabolic features can influence the efficacy of probiotics treatments for depression. This trial involved a parallel-group, prospective, randomized, double-blind, controlled design. In total, 116 participants with depression received a probiotic preparation containing Lactobacillus helveticus Rosell (R)-52 and Bifidobacterium longum Rosell (R)-175 or placebo over 60 days. The psychometric data were assessed longitudinally at five time-points. Data for blood pressure, body weight, waist circumference, complete blood count, serum levels of C-reactive protein, cholesterol, triglycerides, and fasting glucose were measured at the beginning of the intervention period. There was no advantage of probiotics usage over placebo in the depression score overall (PRO vs. PLC: F(1.92) = 0.58; p = 0.45). However, we found a higher rate of minimum clinically important differences in patients supplemented with probiotics than those allocated to placebo generally (74.5 vs. 53.5%; X2(1,n = 94) = 4.53; p = 0.03; NNT = 4.03), as well as in the antidepressant-treated subgroup. Moreover, we found that the more advanced the pre-intervention metabolic abnormalities (such as overweight, excessive central adipose tissue, and liver steatosis), the lower the improvements in psychometric scores. A higher baseline stress level was correlated with better improvements. The current probiotic formulations may only be used as complementary treatments for depressive disorders. Metabolic abnormalities may require more complex treatments. ClinicalTrials.gov identifier: NCT04756544.
C1 [Gawlik-Kotelnicka, Oliwia; Skowronska, Anna; Strzelecki, Dominik] Med Univ Lodz, Dept Affect & Psychot Disorders, Czechoslowacka St 251, PL-92216 Lodz, Poland.
   [Margulska, Aleksandra] Med Univ Lodz, Dept Adolescent Psychiat, Czechoslowacka St 8-10, PL-92216 Lodz, Poland.
   [Pleska, Kacper] Med Univ Lodz, Fac Med, Kosciuszki Ave 4, PL-90419 Lodz, Poland.
C3 Medical University Lodz; Medical University Lodz; Medical University
   Lodz
RP Gawlik-Kotelnicka, O (corresponding author), Med Univ Lodz, Dept Affect & Psychot Disorders, Czechoslowacka St 251, PL-92216 Lodz, Poland.
EM oliwia.gawlik@umed.lodz.pl; aleksandra.margulska@umed.lodz.pl;
   pleskakacper@gmail.com; anna.zabka@gmail.com;
   dominik.strzelecki@umed.lodz.pl
RI Gawlik-Kotelnicka, Oliwia/ITU-7979-2023; Strzelecki,
   Dominik/S-9340-2016; Gawlik-Kotelnicka, Oliwia/S-9936-2016
OI Strzelecki, Dominik/0000-0002-8559-1078; Gawlik-Kotelnicka,
   Oliwia/0000-0003-1398-3117; Margulska, Aleksandra/0000-0003-1229-0925;
   Pleska, Kacper/0000-0001-8495-8766
FU Medical University of Lodz
FX No Statement Available
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NR 81
TC 7
Z9 7
U1 3
U2 13
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD MAY
PY 2024
VL 16
IS 9
AR 1389
DI 10.3390/nu16091389
PG 21
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA QG8H6
UT WOS:001219813000001
PM 38732635
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Amiri, P
   Hosseinpanah, F
   Rambod, M
   Montazeri, A
   Azizi, F
AF Amiri, Parisa
   Hosseinpanah, Farhad
   Rambod, Mehdi
   Montazeri, Ali
   Azizi, Fereidoun
TI Metabolic Syndrome Predicts Poor Health-Related Quality of Life in Women
   but Not in Men: Tehran Lipid and Glucose Study
SO JOURNAL OF WOMENS HEALTH
LA English
DT Article
ID CARDIOVASCULAR-DISEASE; PREVALENCE; MORTALITY; IMPACT; SF-36
AB Objective: To compare health-related quality of life (HRQOL) in those with and without metabolic syndrome in a general Iranian population.
   Methods: This was a cross-sectional study of HRQOL conducted in a sample of individuals with and without metabolic syndrome using the data obtained from the Tehran Lipid and Glucose Study (TLGS) and information specifically collected for the present investigation. Metabolic syndrome was defined according to the adult treatment panel III (ATPIII) and HRQOL was assessed using the Short Form Health Survey (SF-36). Logistic regression analyses were performed for the whole sample and both sexes while adjusting for potential confounders in order to estimate odds ratios for predicting HRQOL in this population.
   Results: In all, 950 participants with (n = 361) and without (n = 589) metabolic syndrome were studied. The mean age of participants was 46.5 +/- 14.4 years. In women, but not in men, metabolic syndrome had an independent role in predicting poor HRQOL. With increase in the number of metabolic syndrome components, there was a significant decreasing trend in women's physical component summary scores.
   Conclusions: The results indicate that metabolic syndrome is associated with poor HRQOL in women but not in men, and the association is formed mainly in relation to physical rather than mental health.
C1 [Amiri, Parisa; Hosseinpanah, Farhad; Rambod, Mehdi] Shahid Beheshti Univ Med Sci, Res Inst Endocrine Sci, Obes Res Ctr, Tehran, Iran.
   [Montazeri, Ali] ACECR, Iranian Inst Hlth Sci Res, Dept Mental Hlth, Tehran, Iran.
   [Azizi, Fereidoun] Shahid Beheshti Univ Med Sci, Res Inst Endocrine Sci, Endocrine Res Ctr, Tehran, Iran.
C3 Shahid Beheshti University Medical Sciences; Academic Center for
   Education, Culture & Research (ACECR); Shahid Beheshti University
   Medical Sciences
RP Hosseinpanah, F (corresponding author), Shahid Beheshti Univ Med Sci, Res Inst Endocrine Sci, Obes Res Ctr, Tehran, Iran.
EM fhospanah@endocrine.ac.ir
RI Montazeri, Ali/C-9276-2009; hosseinpanah, farhad/AAM-7277-2020; Amiri,
   Parisa/K-1575-2017; Azizi, Fereidoun/ABD-4136-2021
OI Amiri, Parisa/0000-0002-6693-1057; Azizi, Fereidoun/0000-0002-6470-2517;
   Montazeri, Ali/0000-0002-5198-9539
FU Obesity Research Center, Research Institute for Endocrine Sciences,
   Shahid Beheshti University of Medical Sciences, Tehran, Iran
FX This study is funded by the Obesity Research Center, Research Institute
   for Endocrine Sciences, Shahid Beheshti University of Medical Sciences,
   Tehran, Iran. We acknowledge the assistance of Mrs. Niufar Shiva in
   preparation and editing of the manuscript and also express appreciation
   to the participants of the Tehran Lipid and Glucose Study.
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NR 33
TC 30
Z9 32
U1 0
U2 5
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-9996
EI 1931-843X
J9 J WOMENS HEALTH
JI J. Womens Health
PD JUN
PY 2010
VL 19
IS 6
BP 1201
EP 1207
DI 10.1089/jwh.2009.1710
PG 7
WC Public, Environmental & Occupational Health; Medicine, General &
   Internal; Obstetrics & Gynecology; Women's Studies
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; General & Internal
   Medicine; Obstetrics & Gynecology; Women's Studies
GA 610YB
UT WOS:000278775400019
PM 20482255
DA 2025-06-11
ER

PT J
AU Magnavita, N
   Fileni, A
AF Magnavita, Nicola
   Fileni, Adriano
TI Work stress and metabolic syndrome in radiologists: first evidence
SO RADIOLOGIA MEDICA
LA English
DT Article
DE Work-related stress; Radiologist; Metabolic syndrome; Hypertension;
   Obesity; Elevated triglycerides; Reduced HDL cholesterol; Glucose
   intolerance; Job strain; Effort-reward imbalance; Overcommitment; Social
   support
ID EFFORT-REWARD IMBALANCE; CORONARY-HEART-DISEASE; BODY-MASS INDEX;
   NATIONAL-HEALTH; RISK-FACTORS; JOB STRAIN; PREVALENCE; BURNOUT; SAMPLE;
   COHORT
AB Purpose Scientific data have amply demonstrated that work stress increases the risk of cardiovascular disease. However, less attention has been given to the association between stress and metabolic syndrome. In this study, our aim was to investigate the relationship between work stress and metabolic syndrome in a population of radiologists.
   Radiologists and radiotherapists taking part in scientific conferences were invited to compile a questionnaire to evaluate work stress and the main parameters for diagnosing metabolic syndrome (obesity, hypertension, elevated cholesterol level, elevated triglycerides, and hyperglycemia).
   Most of the doctors taking part in the survey (n = 383, 58.6 %) were found to have at least one pathological component; 47 subjects (7.1 %) had metabolic syndrome. All the variables indicating work stress, whether derived from Karasek's demand/control model or from the effort/reward model devised by Siegrist, were significant predictors of metabolic syndrome components. Radiologists with elevated levels of stress had a significantly higher risk of being affected by metabolic syndrome than colleagues with lower stress levels, whether stress was defined as "job strain", i.e., elevated work load and reduced discretionary power (OR 4.89, 95 % CI 2.51-9.55), or as "effort reward imbalance", i.e., mismatch between effort and reward for the work performed (OR 4.66, 95 % CI 2.17-10.02).
   Should the results of this cross-sectional study be confirmed by a subsequent longitudinal survey, they would indicate the need for prompt organizational intervention to reduce occupational stress in radiologists.
C1 [Magnavita, Nicola] Univ Cattolica Sacro Cuore, Dept Publ Hlth, I-00168 Rome, Italy.
   [Fileni, Adriano] Ist Nazl Malattia Infett INMI Lazzaro Spallanzani, Rome, Italy.
C3 Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli
RP Magnavita, N (corresponding author), Univ Cattolica Sacro Cuore, Dept Publ Hlth, Largo Gemelli 8, I-00168 Rome, Italy.
EM nicolamagnavita@gmail.com
RI Magnavita, Nicola/J-6074-2014
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NR 57
TC 40
Z9 43
U1 0
U2 14
PU SPRINGER-VERLAG ITALIA SRL
PI MILAN
PA VIA DECEMBRIO, 28, MILAN, 20137, ITALY
SN 0033-8362
EI 1826-6983
J9 RADIOL MED
JI Radiol. Med.
PD FEB
PY 2014
VL 119
IS 2
BP 142
EP 148
DI 10.1007/s11547-013-0329-0
PG 7
WC Radiology, Nuclear Medicine & Medical Imaging
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Radiology, Nuclear Medicine & Medical Imaging
GA AB7JF
UT WOS:000331965100009
PM 24297580
DA 2025-06-11
ER

PT J
AU Manczak, EM
   Millwood, SN
   Waxman, M
AF Manczak, Erika M.
   Millwood, Summer N.
   Waxman, Megan
TI A healthy balance: the ratio of social support-to-demands is associated
   with metabolic syndrome
SO JOURNAL OF BEHAVIORAL MEDICINE
LA English
DT Article
DE Metabolic syndrome; Social relationships; Family; Friendship; Social
   demands
ID CARDIOVASCULAR-DISEASE; DEPRESSIVE SYMPTOMS; MARITAL QUALITY;
   MENTAL-HEALTH; RISK-FACTORS; INFLAMMATION; STRAIN; LONELINESS;
   DEFINITION; PREVALENCE
AB Metabolic syndrome is associated with increased risk for negative health events, decrements in quality of life, and greater health costs. The current study sought to identify whether the ratio of social support to social demands across multiple relationship types (spouse, friends, children, or other family members) were associated with concurrent metabolic syndrome in a nationally representative sample of US adults ages 32-40. Results indicate that the ratio of total social support to social demands was associated with a greater likelihood of meeting criteria for metabolic syndrome, even after statistically controlling for the effects of race, ethnicity, sex, age, income, and prior metabolic syndrome. When considering the relative contributions of each relationship type, greater support relative to demands from friends was the only relationship type that was significantly independently associated with lower likelihood of metabolic syndrome. Although not statistically significant, a trend-level negative association with spousal support/demands emerged, as did a trend-level positive association with support/demands from children. Taken together, the current study reaffirms the relevance of considering social support and demands with regards to metabolic syndrome and highlights the ways in which specific relationships may differentially relate to health risk.
C1 [Manczak, Erika M.; Millwood, Summer N.; Waxman, Megan] Univ Denver, Dept Psychol, 2155 Race St, Denver, CO 80208 USA.
C3 University of Denver
RP Manczak, EM (corresponding author), Univ Denver, Dept Psychol, 2155 Race St, Denver, CO 80208 USA.
EM erika.manczak@du.edu
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NR 36
TC 0
Z9 0
U1 1
U2 4
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0160-7715
EI 1573-3521
J9 J BEHAV MED
JI J. Behav. Med.
PD APR
PY 2024
VL 47
IS 2
BP 348
EP 354
DI 10.1007/s10865-023-00456-0
EA NOV 2023
PG 7
WC Psychology, Clinical
WE Social Science Citation Index (SSCI)
SC Psychology
GA LB8M8
UT WOS:001099476000002
PM 37946025
DA 2025-06-11
ER

PT J
AU Janney, CA
   Masheb, RM
   Lutes, LD
   Holleman, RG
   Kim, HM
   Gillon, LR
   Damschroder, LJ
   Richardson, CR
AF Janney, Carol A.
   Masheb, Robin M.
   Lutes, Lesley D.
   Holleman, Robert G.
   Kim, Hyungjin Myra
   Gillon, Leah R.
   Damschroder, Laura J.
   Richardson, Caroline R.
TI Mental health and behavioral weight loss: 24-month outcomes in Veterans
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE SMI; Anxiety; Depression; Small changes; Behavioral weight loss
ID LIFE-STYLE INTERVENTIONS; BIPOLAR-DISORDER; METABOLIC SYNDROME;
   PHYSICAL-ACTIVITY; OBESITY TREATMENT; LOSS MAINTENANCE; MANAGEMENT;
   OVERWEIGHT; PROGRAM; DEPRESSION
AB Background: Individuals with mental health (MH) disorders have an increased risk of being overweight/obese; however research on behavioral weight loss interventions has been limited. A priori hypothesis was that Veterans with serious mental illness (SMI) and/or affective disorders (AD) would lose significantly less weight and have a different pattern of weight loss than Veterans without these diagnoses.
   Methods: Secondary data analysis of ASPIRE-VA study, three-arm randomized, effectiveness weight loss trial among Veterans (n=409) categorized by MH diagnoses: 1) SMI, 2) AD without SMI, or 3) No SMI/No AD. Linear mixed-effects model analyzed weight changes from baseline thru 24 months.
   Results: SMI and AD were diagnosed in 10% (n=41) and 31% (n=125). Participants attended approximately 15 sessions from baseline to 24 months. On average, participants lost a modest amount of weight over 24 months regardless of MH diagnosis. Longitudinally, no statistically significant differences were found in weight loss patterns by MH diagnosis. Unadjusted average weight loss (kg) was 1.6 +/- 4.0 at 3 months (n=373), 1.9 +/- 6.5 at 12 months (n=361), 1.5 +/- 7.8 at 18 months (n=289), and 1.4 +/- 8.0 at 24 months (n=279).
   Limitations: ASPIRE-VA study was not designed or powered to detect weight loss differences among MH diagnostic groups.
   Conclusions: Veterans achieved and maintained modest weight loss, through 24 months, with the three behavioral weight loss interventions. Contrary to our hypotheses, the amount and pattern of weight loss did not differ by MH diagnosis. Greater inclusion of individuals with MH diagnoses may be warranted in behavioral weight loss interventions not specifically tailored for them.
C1 [Janney, Carol A.; Holleman, Robert G.; Kim, Hyungjin Myra; Gillon, Leah R.; Damschroder, Laura J.; Richardson, Caroline R.] VA Ann Arbor Healthcare Syst, VA Ctr Clin Management Res, 2215 Fuller Rd, Ann Arbor, MI 48105 USA.
   [Janney, Carol A.] Michigan State Univ, Coll Human Med, Midland Reg Campus Ctr, 4611 Campus Ridge Dr, Midland, MI 48670 USA.
   [Masheb, Robin M.] Yale Sch Med, Dept Psychiat, New Haven, CT USA.
   [Masheb, Robin M.] VA Connecticut Healthcare Syst, PRIME Ctr, 11ACSLG,950 Campbell Ave, West Haven, CT 06516 USA.
   [Lutes, Lesley D.] Univ British Columbia Okanagan, Dept Psychol, 3187 Univ Way, Kelowna, BC V1V 1V7, Canada.
   [Kim, Hyungjin Myra] Univ Michigan, Ctr Stat Consultat & Res, Ann Arbor, MI 48109 USA.
C3 US Department of Veterans Affairs; Veterans Health Administration (VHA);
   VA Ann Arbor Healthcare System; Michigan State University; Michigan
   State University College of Human Medicine; Yale University; US
   Department of Veterans Affairs; Veterans Health Administration (VHA); VA
   Connecticut Healthcare System; University of British Columbia;
   University of British Columbia Okanagan; University of Michigan System;
   University of Michigan
RP Richardson, CR (corresponding author), Univ Michigan, Sch Med, Dept Family Med, 1018 Fuller St, Ann Arbor, MI 48109 USA.
EM carol.janney@hc.msu.edu; Robin.Masheb@Yale.edu; lesley.lutes@ubc.ca;
   Rob.Holleman@va.gov; myrakim@umich.edu; Leah.Gillon@va.gov;
   Laura.Damschroder@va.gov; caroli@umich.edu
RI Richardson, Caroline/A-9237-2009; Damschroder, Laura/A-1142-2007
OI Damschroder, Laura J./0000-0002-3657-8459; Janney,
   Carol/0000-0002-4821-4679; Richardson, Caroline/0000-0002-1945-6046
FU VA HSR&D/Diabetes QUERI [IBB 09-034]; VA Center for Clinical Management
   Research, Health Services Research and Development as a post-doctoral
   fellow at the VA Aim Arbor Healthcare System
FX Funded by VA HSR&D/Diabetes QUERI, #IBB 09-034; CAJ was supported by the
   VA Center for Clinical Management Research, Health Services Research and
   Development as a post-doctoral fellow at the VA Aim Arbor Healthcare
   System. The funding bodies had no role in the manuscript other than
   financial support. The views expressed in this article are those of the
   authors and do not necessarily represent the views of the Department of
   Veterans Affairs.
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NR 55
TC 9
Z9 9
U1 0
U2 8
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD JUN
PY 2017
VL 215
BP 197
EP 204
DI 10.1016/j.jad.2017.03.003
PG 8
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA EU7KI
UT WOS:000401213300027
PM 28340446
DA 2025-06-11
ER

PT J
AU Canini, F
   Qin, BL
   Arvy, N
   Poulet, L
   Batandier, C
   Roussei, AM
   Anderson, RA
AF Canini, Frederic
   Qin, Bolin
   Arvy, Nathalie
   Poulet, Laurent
   Batandier, Cecile
   Roussei, Anne-Marie
   Anderson, Richard A.
TI Stress exposure alters brain mRNA expression of the genes involved in
   insulin signalling, an effect modified by a high fat/high fructose diet
   and cinnamon supplement
SO PLOS ONE
LA English
DT Article
ID TYPE-2 DIABETES-MELLITUS; HIGH-FAT DIET; CENTRAL-NERVOUS-SYSTEM;
   OXIDATIVE STRESS; RESTRAINT STRESS; PSYCHOLOGICAL STRESS; METABOLIC
   SYNDROME; MAJOR DEPRESSION; CEREBRAL-CORTEX; RISK-FACTOR
AB In occidental societies, high fat and high sugar diets often coincide with episodes of stress. The association is likely to modify brain energy control. Brain insulin signalling is rarely studied in stressed individuals consuming high fat diets. Furthermore the effects of cinnamon supplement are not known in these conditions. Therefore, we exposed rats, over a 12-week period, to a control (C) or a high fat/high fructose (HF/HFr) diet that induces peripheral insulin resistance. A cinnamon supplement (C+CN and HF/HFr+CN) was added or not. After diet exposure, one group of rats was exposed to a 30-min restraint followed by a 10-min open-field test, their combination featuring a moderate stressor, the other rats staying unstressed in their home cages. The insulin signalling in hippocampus and frontal cortex was studied through the mRNA expression of the following genes: insulin receptor (Ir), insulin receptor substrate (Irs1), glucose transporters (Glut1 and Glut3), glycogen synthase (Gys1) and their modulators, Akt1 and Pten. In C rats, stress enhanced the expression of Ir, Irs1, Glut1, Gys1 and Akt1 mRNA. In C+CN rats, stress induced an increase in Pten but a decrease in Gys1 mRNA expression. In HF/HFr rats, stress was associated with an increase in Pten mRNA expression. In HF/HFr+CN rats, stress increased Pten mRNA expression but also decreased Gys1 mRNA expression. This suggests that a single moderate stress favours energy refilling mechanisms, an effect blunted by a previous HF/HFr diet and cinnamon supplement.
C1 [Canini, Frederic] IRBA, Dept Neurosci & Contraintes Operat, Bretigny Sur Orge, France.
   [Canini, Frederic] Ecole Val Grace, 1 Pl Laveran, Paris, France.
   [Qin, Bolin] In Ingredients Com, Columbia, TN USA.
   [Qin, Bolin; Anderson, Richard A.] ARS, Diet Genom & Immunol Lab, Beltsville Human Nutr Res Ctr, USDA, Beltsville, MD USA.
   [Arvy, Nathalie] INRA, Lab Nutr & Integrat Neurobiol, UMR 1286, Bordeaux, France.
   [Arvy, Nathalie] Univ Bordeaux, Lab Nutr & Integrat Neurobiol, UMR 1286, Bordeaux, France.
   [Poulet, Laurent; Batandier, Cecile; Roussei, Anne-Marie] Grenoble Alpes Univ, INSERM, LBFA 1055, Grenoble, France.
   [Anderson, Richard A.] PolyChrom Technol LLC, Edgewater, MD USA.
C3 United States Department of Agriculture (USDA); INRAE; Institut National
   de la Sante et de la Recherche Medicale (Inserm); Universite de
   Bordeaux; Universite de Bordeaux; Institut National de la Sante et de la
   Recherche Medicale (Inserm); Communaute Universite Grenoble Alpes;
   Universite Grenoble Alpes (UGA); Institut National de la Sante et de la
   Recherche Medicale (Inserm)
RP Canini, F (corresponding author), IRBA, Dept Neurosci & Contraintes Operat, Bretigny Sur Orge, France.; Canini, F (corresponding author), Ecole Val Grace, 1 Pl Laveran, Paris, France.
EM fredericcanini@gmail.com
RI Marissal-Arvy, Nathalie/AAL-6103-2021
OI Poulet, Laurent/0000-0003-2795-4122
FU USDA/ARS/USA CRADA [58-3K95-7-1184]; French National Agency for Research
   [PNRA 007]
FX The work was funded by USDA/ARS/USA CRADA: 58-3K95-7-1184 and French
   National Agency for Research (PNRA 007). The funders provided support in
   the form of salary for one of the authors [BQ], but did not have any
   additional role in the study design, data collection and analysis,
   decision to publish, or preparation of the manuscript. The specific
   roles of the authors are articulated in the 'author contributions'
   section.
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NR 70
TC 2
Z9 3
U1 0
U2 7
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAY 29
PY 2018
VL 13
IS 5
AR e0197094
DI 10.1371/journal.pone.0197094
PG 15
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA GH6AR
UT WOS:000433521800011
PM 29813096
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Peein, I
   Reiner, I
AF Peein, Ivan
   Reiner, Ieljko
TI METABOLIC SYNDROME, MORBIDITY AND MORTLITY IN THE ERA OF COVID-19
   PANDEMIC
SO PSYCHIATRIA DANUBINA
LA English
DT Article
DE metabolic syndrome; COVID-19
ID CORONARY-HEART-DISEASE; RISK-FACTORS; CHOLESTEROL; INSULIN; ADULTS;
   ISLAND
AB The prevalence of obesity, diabetes, arterial hypertension and cardiovascular and cerebrovascular diseases is increasing worldwide. Nowdays we are witnessing a pandemic of metabolic syndrome and obesity and an epidemic of these diseases in Croatia as well. Moreover, every second Croatian citizen dies because of cardiovascular diseases. Visceral obesity, diabetes, dyslipidemia and arterial hypertension tend to cluster forming a syndrome that we call metabolic syndrome. The concept of metabolic syndrome was defined several decades ago as visceral type of obesity, hypertriglyceridemia, low HDL-cholesterol, arterial hypertension and diabetes mellitus (insulin resistance). Most widely used definition is the one by National Education Cholesterol Program, NCEP Adult treatment Panel III - ATP III. Therefore, visceral obesity is considered as one of the greatest risks for mortality worldwide. COVID pandemia increased the risk od deaths especially among patients with metabolic syndrome. Pandemia perpetuated several other socio-economical risk factors (stress, depression, physical inactivity, devian strongly influence cardiovascular health. Unfortunately, SARS-COV-2 virus enters the host (human) cell using signaling pathways (ANG II Rc) known very well from the metabolic syndrome research and connecting those two entities predesponing these patients for a much worse prognosis when infected with SARS-COV-2 virus. To conclude - chronic obesity pandemia goes hand by hand with novel COVID-19 pandemia dramatiacally increasing the risk of severe morbidity and mortality.
C1 [Peein, Ivan] Univ Hosp Ctr Zagreb, Dept Internal Dis, Zagreb, Croatia.
   Univ Zagreb, Sch Med, Zagreb, Croatia.
C3 University of Zagreb; UNIVERSITY ZAGREB HOSPITAL; University of Zagreb
RP Peein, I (corresponding author), Univ Hosp Ctr Zagreb, Dept Internal Dis, Zagreb, Croatia.
EM ipecin@kbc-zagreb.hr
CR Aguiar C, 2015, ATHEROSCLEROSIS SUPP, V19, DOI 10.1016/S1567-5688(15)30001-5
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NR 22
TC 0
Z9 0
U1 0
U2 3
PU MEDICINSKA NAKLADA
PI ZAGREB
PA VLASKA 69, HR-10000 ZAGREB, CROATIA
SN 0353-5053
EI 1849-0867
J9 PSYCHIAT DANUB
JI Psychiatr. Danub.
PY 2021
VL 33
SU 4
BP S441
EP S444
PG 4
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA WV9LF
UT WOS:000717549900005
DA 2025-06-11
ER

PT J
AU Huang, YC
   Lin, PY
   Lee, Y
   Lee, CY
   Lo, YC
   Hung, CF
   Chen, CS
AF Huang, Yu-Chi
   Lin, Pao-Yen
   Lee, Yu
   Lee, Chun-Yi
   Lo, Yi-Ching
   Hung, Chi-Fa
   Chen, Cheng-Sheng
TI Metabolic syndrome components and leukocyte telomere length in patients
   with major depressive disorder
SO WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
LA English
DT Article
DE Ageing; telomere; metabolic syndrome; depression; HDL-C
ID BIPOLAR DISORDER; YOUNG-ADULTS; ASSOCIATIONS; STRESS; LIFE;
   EPIDEMIOLOGY; PREVALENCE; NUTRITION; CORTISOL; ANXIETY
AB Objectives The relationship between metabolic syndrome (MetS) components and leukocyte telomere length (LTL) attrition in major depressive disorder (MDD) remains unclear. Methods We recruited 70 MDD patients (mean age: 44.6 years, 60.0% female) and 51 age- and sex-matched controls (mean age: 41.2 years, 68.6% female) to examine the associations of MetS components and LTL. Five MetS components-waist circumference, systolic/diastolic blood pressure, serum levels of fasting glucose, high-density lipoprotein cholesterol (HDL-C), and triglycerides-were assessed. LTL was measured through quantitative polymerase chain reaction. Results MDD had higher prevalence of MetS (34.3 vs. 17.6%, p=.042), low HDL-C (25.7 vs. 7.8%, p=.009) and shorter LTL (-0.038 +/- 0.169 vs. 0.033 +/- 0.213, p=.042). Regression analysis revealed that MDD (p=.046) and age (p=.003) associated with LTL, while a significant interaction effect of group (MDD vs. controls) x HDL-C (p=.037) was observed. Post-hoc analysis showed MDD with low HDL-C had greater LTL attrition than controls without low HDL-C (p=.020). In MDD, HDL-C dysregulation negatively correlated with LTL (p=.010); but no significance after Bonferroni correction. Conclusions HDL-C may be involved in accelerated ageing process regarding metabolic disturbance in MDD only. The relationship merits prospective investigations with larger sample size for clarification.
C1 [Huang, Yu-Chi] Kaohsiung Med Univ, Coll Med, Grad Inst Clin Med, Kaohsiung, Taiwan.
   [Huang, Yu-Chi; Lin, Pao-Yen; Lee, Yu; Lee, Chun-Yi; Hung, Chi-Fa] Kaohsiung Chang Gung Mem Hosp, Dept Psychiat, Kaohsiung, Taiwan.
   [Huang, Yu-Chi; Lin, Pao-Yen; Lee, Yu; Lee, Chun-Yi; Hung, Chi-Fa] Chang Gung Univ, Coll Med, Kaohsiung, Taiwan.
   [Lin, Pao-Yen] Kaohsiung Chang Gung Mem Hosp, Inst Translat Res Biomed Sci, Kaohsiung, Taiwan.
   [Lo, Yi-Ching] Kaohsiung Med Univ, Coll Med, Dept Pharmacol, Kaohsiung, Taiwan.
   [Chen, Cheng-Sheng] Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Psychiat, Kaohsiung, Taiwan.
   [Chen, Cheng-Sheng] Kaohsiung Med Univ, Coll Med, Kaohsiung, Taiwan.
C3 Kaohsiung Medical University; Chang Gung Memorial Hospital; Chang Gung
   University; Chang Gung Memorial Hospital; Kaohsiung Medical University;
   Kaohsiung Medical University; Kaohsiung Medical University Hospital;
   Kaohsiung Medical University
RP Hung, CF (corresponding author), Kaohsiung Chang Gung Mem Hosp, Dept Psychiat, Kaohsiung, Taiwan.; Hung, CF (corresponding author), Chang Gung Univ, Coll Med, Kaohsiung, Taiwan.; Chen, CS (corresponding author), Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Psychiat, Kaohsiung, Taiwan.; Chen, CS (corresponding author), Kaohsiung Med Univ, Coll Med, Kaohsiung, Taiwan.
EM chifa.hung@gmail.com; sheng@kmu.edu.tw
RI Lo, Yi-Ching/A-1536-2010; Lin, Pao-Yen/V-2495-2019
OI Huang, Yu-Chi/0000-0002-1143-9073; Lo, Yi-Ching/0000-0003-1745-655X
FU Chang Gung Memorial Hospital Research Project [CMRPG8G1071, CMRPG8J1141]
FX This study was supported by the Chang Gung Memorial Hospital Research
   Project (CMRPG8G1071, CMRPG8J1141). The funding sources had no
   involvement in the study design, participant recruitment, data
   collection, analysis and interpretation, report writing, or the decision
   of submission for publication.
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NR 57
TC 12
Z9 12
U1 0
U2 8
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1562-2975
EI 1814-1412
J9 WORLD J BIOL PSYCHIA
JI World J. Biol. Psychiatry
PD JUL 3
PY 2022
VL 23
IS 6
BP 483
EP 492
DI 10.1080/15622975.2021.2013091
EA DEC 2021
PG 10
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychiatry
GA 6C2JG
UT WOS:000730975600001
PM 34854357
DA 2025-06-11
ER

PT J
AU Müller-Wieland, D
   Altenburg, C
   Becher, H
   Burchard, J
   Frisch, A
   Gebhard, J
   Haas, J
   Harth, V
   Heeren, J
   Hengelbrock, J
   von Karais, M
   Knebel, B
   Kotzka, J
   Löwe, B
   Marx, N
   Pinnschmidt, H
   Preisser, A
   Rose, M
   Sawitzky-Rose, B
   Scheja, L
   Terschüren, C
   Töller, M
   Vettorazzi, E
   Wegscheider, K
AF Mueller-Wieland, Dirk
   Altenburg, Christiane
   Becher, Heiko
   Burchard, Janine
   Frisch, Anett
   Gebhard, Jan
   Haas, Jutta
   Harth, Volker
   Heeren, Joerg
   Hengelbrock, Johannes
   von Karais, Maximilian
   Knebel, Birgit
   Kotzka, Joerg
   Loewe, Bernd
   Marx, Nikolaus
   Pinnschmidt, Hans
   Preisser, Alexandra
   Rose, Matthias
   Sawitzky-Rose, Barbara
   Scheja, Ludger
   Terschueren, Claudia
   Toeller, Monika
   Vettorazzi, Eik
   Wegscheider, Karl
TI Development of the Metabolic Syndrome: Study Design and Baseline Data of
   the Lufthansa Prevention Study (LOPS), A Prospective Observational
   Cohort Survey
SO EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
LA English
DT Article
DE insulin resistance; nutrition; visceral obesity; dyslipidemia; fasting
   plasma glucose; depression
ID PERCEIVED STRESS QUESTIONNAIRE; GENERALIZED ANXIETY DISORDER; HABITUAL
   PHYSICAL-ACTIVITY; CARDIOVASCULAR-DISEASE; DIETARY PATTERNS;
   PRIMARY-CARE; RISK; VALIDATION; VALIDITY; CONSEQUENCES
AB The Lufthansa Prevention Study (CUPS) study is a prospective observation of a healthy worker cohort to identify early changes in metabolism leading to the Metabolic Syndrome (MetS) and to analyze their relation to behavioral factors like nutrition, physical activity, psychological status, and to underlying genetic conditions. The CUPS study recruited a sample of 1.962 non-diabetic healthy adults between 25-60 years, employed at a flight base of Lufthansa Technik GmbH in Hamburg, Germany. Baseline assessments included anthropometric measures, blood and urine samples and medical history. Psychosocial variables, dietary habits and life-style risk factors were assessed via self-reported questionnaires.
   In this report we describe the study design and present baseline parameters including the prevalence of the MetS using different classification criteria. The MetS was present in 20% of male and 12 % of female subjects according to the 'Harmonizing the metabolic syndrome' definition. The prevalence varies between 2.6% in male and 2.3 % in female subjects up to 48% in male and 41 % in female subjects according to different classification criteria of MetS.
   In conclusion, this first cross-sectional view on the LUPS data confirms the expectation that this cohort is rather healthy and thus provides the opportunity to analyze early changes associated with the development of the MetS.
C1 [Mueller-Wieland, Dirk; Marx, Nikolaus] Univ Hosp Aachen, Dept Med 1, Aachen, Germany.
   [Altenburg, Christiane] Univ Med Ctr Hamburg Eppendorf, Dept Med, Hamburg, Germany.
   [Becher, Heiko; Hengelbrock, Johannes; Pinnschmidt, Hans; Vettorazzi, Eik; Wegscheider, Karl] Univ Med Ctr Hamburg Eppendorf, Inst Med Biometry & Epidemiol, Hamburg, Germany.
   [Burchard, Janine; Frisch, Anett; Haas, Jutta] Semmelweis Univ, Asklepios Med Sch, Campus Hamburg, Hamburg, Germany.
   [Gebhard, Jan; von Karais, Maximilian] Aeromed Ctr Lufthansa, Hamburg, Germany.
   [Harth, Volker; Preisser, Alexandra; Terschueren, Claudia] Univ Med Ctr Hamburg Eppendorf, Inst Occupat & Maritime Med, Hamburg, Germany.
   [Heeren, Joerg; Scheja, Ludger] Univ Med Ctr Hamburg Eppendorf, Dept Biochjemistry & Mol Cell Biol, Hamburg, Germany.
   [Knebel, Birgit; Kotzka, Joerg] Heinrich Heine Univ Dusseldorf, Leibniz Ctr Diabet Res, Inst Clin Biochem & Pathobiochem, German Diabet Ctr, Dusseldorf, Germany.
   [Loewe, Bernd] Univ Med Ctr Hamburg Eppendorf, Dept Psychosomat Med & Psychotherapy, Hamburg, Germany.
   [Rose, Matthias] Charite, Dept Psychosomat Med, Med Ctr, Berlin, Germany.
   [Sawitzky-Rose, Barbara] Diabet Ctr Berlin Rose, Berlin, Germany.
   [Toeller, Monika] Heinrich Heine Univ, Univ Hosp Dusseldorf, Dept Endocrinol Diabetol & Rheeumatol, Dusseldorf, Germany.
C3 RWTH Aachen University; RWTH Aachen University Hospital; University of
   Hamburg; University Medical Center Hamburg-Eppendorf; University of
   Hamburg; University Medical Center Hamburg-Eppendorf; Semmelweis
   University; University of Hamburg; University Medical Center
   Hamburg-Eppendorf; University of Hamburg; University Medical Center
   Hamburg-Eppendorf; Leibniz Association; Deutsches Diabetes-Zentrum
   (DDZ); Heinrich Heine University Dusseldorf; University of Hamburg;
   University Medical Center Hamburg-Eppendorf; Berlin Institute of Health;
   Free University of Berlin; Humboldt University of Berlin; Charite
   Universitatsmedizin Berlin; Heinrich Heine University Dusseldorf;
   Heinrich Heine University Dusseldorf Hospital
RP Müller-Wieland, D (corresponding author), Univ Hosp Aachen, Dept Med 1, Clin Res Ctr, Pauwelsstr 30, D-50247 Aachen, Germany.
EM dirmueller@ukaachen.de
RI Löwe, Bernd/AAG-4038-2020; Rose, Matthias/A-8920-2015; Becher,
   Heiko/ABI-1234-2020; Harth, Volker/AGG-1586-2022; Vettorazzi,
   Eik/B-8130-2019; Becher, Heiko/JUV-6456-2023
OI Vettorazzi, Eik/0000-0002-3737-6402; Becher, Heiko/0000-0002-8808-6667;
   Lowe, Bernd/0000-0003-4220-3378; Rose, Matthias/0000-0001-5233-3139;
   Muller-Wieland, Dirk/0000-0002-8807-6442; Kotzka,
   Jorg/0000-0003-1173-9372; Preisser, Alexandra Marita/0000-0002-2957-3545
CR [Anonymous], WORLDW DEF MET SYNDR
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NR 53
TC 2
Z9 2
U1 0
U2 7
PU JOHANN AMBROSIUS BARTH VERLAG MEDIZINVERLAGE HEIDELBERG GMBH
PI STUTTGART
PA RUEDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0947-7349
EI 1439-3646
J9 EXP CLIN ENDOCR DIAB
JI Exp. Clin. Endocrinol. Diabet.
PD DEC
PY 2020
VL 128
IS 12
BP 777
EP 787
DI 10.1055/a-0767-6361
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism
GA PB0WR
UT WOS:000596049000001
PM 30477037
DA 2025-06-11
ER

PT J
AU Roomruangwong, C
   Matsumoto, AK
   Michelin, AP
   Semeao, LD
   Pedrao, JVD
   Moreira, EG
   Sirivichayakul, S
   Carvalho, A
   Barbosa, DS
   Maes, M
AF Roomruangwong, Chutima
   Matsumoto, Andressa Keiko
   Michelin, Ana Paula
   Semeao, Laura de Oliveira
   Pedrao, Joao Victor de Lima
   Moreira, Estefania G.
   Sirivichayakul, Sunee
   Carvalho, Andre
   Barbosa, Decio S.
   Maes, Michael
TI The role of immune and oxidative pathways in menstrual cycle associated
   depressive, physio-somatic, breast and anxiety symptoms: Modulation by
   sex hormones
SO JOURNAL OF PSYCHOSOMATIC RESEARCH
LA English
DT Article
DE Premenstrual syndrome; Depression; Anxiety; Antioxidants; Neuro-immune;
   Inflammation; Oxidative stress; Biomarkers
ID PREMENSTRUAL DYSPHORIC DISORDER; NITROSATIVE STRESS; AUTOIMMUNE
   RESPONSES; METABOLIC SYNDROME; HUMAN ENDOMETRIUM; MAJOR DEPRESSION;
   INFLAMMATION; ANTIOXIDANT; ESTROGEN; PROTEIN
AB Objective: To examine whether 1) immune and nitro-oxidative stress (IO&NS) biomarkers are associated with premenstrual syndrome (PMS); and 2) changes in IO&NS biomarkers during the menstrual cycle (MC) are associated with PMS symptoms and plasma estradiol and progesterone.
   Methods: This longitudinal study examined 41 women who completed the Daily Record of Severity of Problems (DRSP) rating scale during 28 consecutive days and assayed plasma levels of complement C3 and C4, highly sensitive C-reactive protein (hsCRP), haptoglobin (Hp), advanced oxidation protein products (AOPP), lipid hydroperoxides (LOOH), nitric oxide metabolites (NOx), total radical-trapping antioxidant parameter (TRAP), sulfhydryl (-SH) groups and the activity of paraoxonase (PON)1 at days 7 (D7), 14 (D14), 21 (D21) and 28 (D28) of the MC. MC Associated Syndrome (MCAS) was diagnosed when the summed DRSP score during the MC is > 0.666 percentile.
   Results: All biomarkers, except hsCRP, showed significant alterations during the MC. Arylesterase (AREase) was lowered at D28, while LOOH increased at D14 and C4 at D21 in MCAS. Total DRSP scores were predicted by the combined effects of C4 (positively) and AREase and malondialdehyde (MDA) (both inversely associated). Progesterone lowered levels of LOOH, AOPP and C3 and estradiol lowered levels of Hp while both sex hormones increased 4-(chloromethyl)phenyl acetate (CMPA)ase and AREase activities and levels of -SH groups.
   Conclusion: PMS/MCAS is not accompanied by a peripheral inflammatory response. Lowered MDA and antioxidant defenses and increased C4 may play a role in MC symptoms while sex hormones may have a protective effect against oxidative stress toxicity.
C1 [Roomruangwong, Chutima; Maes, Michael] Chulalongkorn Univ, Fac Med, Dept Psychiat, Bangkok, Thailand.
   [Matsumoto, Andressa Keiko; Michelin, Ana Paula; Semeao, Laura de Oliveira; Pedrao, Joao Victor de Lima; Moreira, Estefania G.; Barbosa, Decio S.] Univ Estadual Londrina, Hlth Sci Ctr, Hlth Sci Grad Program, Londrina, PR, Brazil.
   [Sirivichayakul, Sunee] Chulalongkorn Univ, Fac Med, Dept Med, Bangkok, Thailand.
   [Carvalho, Andre] Univ Toronto, Dept Psychiat, Toronto, ON, Canada.
   [Carvalho, Andre] Ctr Addict & Mental Hlth CAMH, Toronto, ON, Canada.
   [Maes, Michael] Med Univ Plovdiv, Dept Psychiat, Plovdiv, Bulgaria.
   [Maes, Michael] Deakin Univ, IMPACT Strateg Res Ctr, Geelong, Vic, Australia.
C3 Chulalongkorn University; Universidade Estadual de Londrina;
   Chulalongkorn University; University of Toronto; University of Toronto;
   Centre for Addiction & Mental Health - Canada; Medical University
   Plovdiv; Deakin University
RP Maes, M (corresponding author), Chulalongkorn Univ, Fac Med, Dept Psychiat, Bangkok, Thailand.
EM Sunee.S@chula.ac.th; andre.carvalho@camh.ca; dr.michaelmaes@hotmail.com
RI Barbosa, Décio/AAE-6351-2019; Carvalho, Andre/AEZ-4001-2022;
   Roomruangwong, Chutima/L-1317-2019; Maes, Michael/B-8546-2011; Moreira,
   Estefania/AAC-5959-2019
FU Ratchadaphiseksomphot Fund, Faculty of Medicine, Chulalongkorn
   University [RA61/016]; Chulalongkorn University; Government Budget;
   Ratchadaphiseksomphot Fund, Chulalongkorn University, Bangkok, Thailand
FX This research has been supported by 1) the Ratchadaphiseksomphot Fund,
   Faculty of Medicine, Chulalongkorn University, grant number RA61/016; 2)
   Chulalongkorn University; Government Budget; and 3) the
   Ratchadaphiseksomphot Fund, Chulalongkorn University, Bangkok, Thailand.
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NR 74
TC 15
Z9 15
U1 0
U2 6
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-3999
EI 1879-1360
J9 J PSYCHOSOM RES
JI J. Psychosomat. Res.
PD AUG
PY 2020
VL 135
AR 110158
DI 10.1016/j.jpsychores.2020.110158
PG 8
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA MN0ZR
UT WOS:000550576400016
PM 32526539
DA 2025-06-11
ER

PT J
AU Vala, M
   Nasli-Esfahani, E
   Peimani, M
   Sanjari, M
   Arzaghi, SM
   Larijani, B
AF Vala, Mahboobeh
   Nasli-Esfahani, Ensieh
   Peimani, Maryam
   Sanjari, Mahnaz
   Arzaghi, Seyed Masoud
   Larijani, Bagher
TI Iran Diabetes Research Roadmap (IDRR) Study; Mental Health in Diabetic
   Patients in Iran: A Review Article
SO IRANIAN JOURNAL OF PUBLIC HEALTH
LA English
DT Review
DE Diabetes; Mental health; Research roadmap; Iran
ID CO-MORBID DEPRESSION; METABOLIC SYNDROME; BIPOLAR-DISORDER; PREVALENCE;
   ADULTS; TYPE-1; NEEDS; METAANALYSIS; ADOLESCENTS; ATTITUDES
AB Background: Diabetes has become a daunting health and medical challenge as well as a hefty economic burden for societies over the past decades. This study was designed to shed light on the overall trend of research across Iran regarding mental health status of diabetic patients.
   Method: Search process of the present study is part of search strategy of Iran Diabetes Research Roadmap (IDRR) study. We performed a thorough search about Iran diabetes research output in national (Iranmedex, Magiran, and SID) and international (Pubmed, ISI and Scopus) databases up to 2015. After removing duplicates, 426documents were remained and categorized by subject category, methodology, WHO classification and NHMRC criteria.
   Results: Most of obtained studies were concerned with quality of life, treatment, intervention, and behavioral disorders. Based on WHO categories, most studies revolved around epidemiology, causes and determinants of health-related outcomes. Methodological classification showed cross-sectional as the favored method of research. In the Australian classification system, most studies were clinical studies. The year 2010 and 2011 had the greatest spike during the study period.
   Conclusion: Overall trend in publication rate of papers related to the mental health is relatively growing. However, the lack of priority setting is obvious and there is a pressing need for more in-depth evaluations, prioritization of study type and interventional studies based on the needs of patients suffering from diabetes.
C1 [Vala, Mahboobeh] Univ Tehran Med Sci, Endocrinol & Metab Clin Sci Inst, Diabet Res Ctr, Tehran, Iran.
   [Nasli-Esfahani, Ensieh] Univ Tehran Med Sci, Endocrinol & Metab Mol Cellular Sci Inst, Metab Disorders Res Ctr, Tehran, Iran.
   [Peimani, Maryam] Univ Tehran Med Sci, Endocrinol & Metab Mol Cellular Sci Inst, Obes & Eating Habits Res Ctr, Tehran, Iran.
   [Peimani, Maryam] Univ Tehran Med Sci, Sch Publ Hlth, Dept Hlth Educ & Promot, Tehran, Iran.
   [Sanjari, Mahnaz; Larijani, Bagher] Univ Tehran Med Sci, Endocrinol & Metab Clin Sci Inst, Endocrinol & Metab Res Ctr, Tehran, Iran.
   [Arzaghi, Seyed Masoud] Univ Tehran Med Sci, Endocrinol & Metab Populat Sci Inst, Elderly Hlth Res Ctr, Tehran, Iran.
C3 Tehran University of Medical Sciences; Tehran University of Medical
   Sciences; Tehran University of Medical Sciences; Tehran University of
   Medical Sciences; Tehran University of Medical Sciences; Tehran
   University of Medical Sciences
RP Arzaghi, SM (corresponding author), Univ Tehran Med Sci, Endocrinol & Metab Populat Sci Inst, Elderly Hlth Res Ctr, Tehran, Iran.
EM dr.arzaghi@gmail.com
RI larijani, Bagher/ABE-3315-2020; Sanjari, Mahnaz/A-1705-2009; Arzaghi,
   Seyed Masoud/AAW-7680-2020
OI Sanjari, Mahnaz/0000-0003-2992-6184; Peimani,
   Maryam/0000-0003-4602-5468; Arzaghi, Seyed Masoud/0000-0002-1867-1596
FU Endocrinology and Metabolism Research Institute, Tehran University of
   Medical Sciences
FX This study was supported by Endocrinology and Metabolism Research
   Institute, Tehran University of Medical Sciences. We wish to thank staff
   at Diabetes Research Center for their sincere assistance in this study.
   The authors declare that there is no conflict of interests.
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NR 29
TC 7
Z9 7
U1 0
U2 7
PU IRANIAN SCIENTIFIC SOCIETY MEDICAL ENTOMOLOGY
PI TEHRAN
PA SCHOOL PUBLIC HEALTH & INST HEALTH RESEARCH, TEHRAN UNIV MEDICAL
   SCIENCES, P O BOX  6446-14155, TEHRAN, 00000, IRAN
SN 2251-6085
EI 2251-6093
J9 IRAN J PUBLIC HEALTH
JI Iran J. Public Health
PY 2017
VL 46
SU 1
BP 47
EP 52
PG 6
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA EZ5TS
UT WOS:000404782000008
DA 2025-06-11
ER

PT J
AU Lee, SY
   Jao, NC
   Gaffey, AE
   Reid, BM
   Vergara-Lopez, C
   Bublitz, MH
   Stroud, LR
AF Lee, Sharon Y.
   Jao, Nancy C.
   Gaffey, Allison E.
   Reid, Brie M.
   Vergara-Lopez, Chrystal
   Bublitz, Margaret H.
   Stroud, Laura R.
TI Female adolescents' early life stress and body mass index: Differential
   effects of anger and anxiety in response to rejection
SO JOURNAL OF ADOLESCENCE
LA English
DT Article
DE body mass index; cardiometabolic; early life stress; interpersonal;
   rejection sensitivity
ID SEX-DIFFERENCES; PHYSICAL-ACTIVITY; PEER REJECTION; DISPLAY RULES;
   CHILDHOOD; SENSITIVITY; CHILDREN; BMI; AGE; AGGRESSION
AB IntroductionEarly life stress is linked to childhood obesity. As children enter adolescence, early life stress may be associated with increased rejection sensitivity, resulting in activation of behavioral and physiological changes that contribute to higher body mass index (BMI). Understanding the potential influence of rejection sensitivity on the association between early life stress and BMI is important to examine in female adolescents. For this secondary data analysis, we hypothesized that female adolescents with greater early life stress and greater rejection sensitivity would exhibit higher BMI-for-age 12 months later.MethodsSeventy-eight adolescents (Mage = 13.1 years; 100% female sex; MBMI = 23.2 kg/m2) in the United States completed study procedures from 2012 to 2016. Among these procedures, the Psychosocial Schedule was used to assess cumulative early life stress and the Children's Rejection Sensitivity Questionnaire was used to assess anger and anxiety in response to rejection. Twelve months later, height and weight were measured to derive BMI-for-age.ResultsHigher early life stress was associated with higher BMI-for-age among female adolescents with low rejection-provoked anger (1 SD below the mean). However, this association was not observed among female adolescents with high rejection-provoked anger (1 SD above the mean). Finally, there was no significant interaction between early life stress and rejection-provoked anxiety in predicting BMI-for-age.ConclusionsExperiencing early life stress may interact with rejection-provoked anger, but not anxiety, to predict BMI-for-age. Findings inform a developmental perspective of how rejection sensitivity may influence the association between early life stress and early cardiometabolic risk.
C1 [Lee, Sharon Y.; Reid, Brie M.; Vergara-Lopez, Chrystal; Bublitz, Margaret H.; Stroud, Laura R.] Brown Univ, Warren Alpert Med Sch, Dept Psychiat & Human Behav, Providence, RI USA.
   [Lee, Sharon Y.; Reid, Brie M.; Vergara-Lopez, Chrystal; Stroud, Laura R.] Miriam Hosp, Ctr Behav & Prevent Med, Providence, RI USA.
   [Jao, Nancy C.] Rosalind Franklin Univ Med & Sci, Dept Psychol, N Chicago, IL USA.
   [Gaffey, Allison E.] Yale Sch Med, Dept Internal Med Cardiovasc Med, New Haven, CT USA.
   [Gaffey, Allison E.] VA Connecticut Healthcare Syst, West Haven, CT USA.
   [Bublitz, Margaret H.] Brown Univ, Warren Alpert Med Sch, Dept Med, Providence, RI USA.
   [Bublitz, Margaret H.] Miriam Hosp, Womens Med Collaborat, Providence, RI USA.
   [Lee, Sharon Y.; Stroud, Laura R.] Ctr Behav & Prevent Med, 164 Summit Ave, Providence, RI 02906 USA.
C3 Brown University; Lifespan Health Rhode Island; Miriam Hospital;
   Rosalind Franklin University of Medicine & Science; Yale University; US
   Department of Veterans Affairs; Veterans Health Administration (VHA); VA
   Connecticut Healthcare System; Brown University; Lifespan Health Rhode
   Island; Miriam Hospital
RP Lee, SY; Stroud, LR (corresponding author), Ctr Behav & Prevent Med, 164 Summit Ave, Providence, RI 02906 USA.
EM Sharon_Y_Lee@brown.edu; Laura_Stroud@brown.edu
RI Stroud, Laura/O-7807-2019
OI Stroud, Laura/0000-0002-2138-968X
FU American Heart Association; National Institutes of Health [R01MH092450,
   T32HD101392, K01HL164670, K23HL168233, K99HD109373, P20GM139767,
   K08DA045935, R01HL157288];  [23CDA1039160]
FX This research was partially supported by the National Institutes of
   Health R01MH092450 to Laura R. Stroud; T32HD101392 to Sharon Y. Lee;
   K01HL164670 to Nancy C. Jao; K23HL168233 to Allison E. Gaffey;
   K99HD109373 to Brie M. Reid; P20GM139767 to Laura R. Stroud with
   research projects to Chrystal Vergara-Lopez and Sharon Y. Lee;
   K08DA045935 to Chrystal Vergara-Lopez; R01HL157288 to Margaret H.
   Bublitz. This research was partially supported by the American Heart
   Association 23CDA1039160 to Sharon Y. Lee.
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NR 82
TC 0
Z9 0
U1 0
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0140-1971
EI 1095-9254
J9 J ADOLESCENCE
JI J. Adolesc.
PD JUN
PY 2024
VL 96
IS 4
BP 830
EP 840
DI 10.1002/jad.12302
EA FEB 2024
PG 11
WC Psychology, Developmental
WE Social Science Citation Index (SSCI)
SC Psychology
GA TG0Z8
UT WOS:001168756300001
PM 38402417
DA 2025-06-11
ER

PT J
AU Senkus, KE
   Tan, L
   Crowe-White, KM
AF Senkus, Katelyn E.
   Tan, Libo
   Crowe-White, Kristi M.
TI Lycopene and Metabolic Syndrome: A Systematic Review of the Literature
SO ADVANCES IN NUTRITION
LA English
DT Review
DE lycopene; metabolic syndrome; ATP III; cardiometabolic; phytochemicals
ID SERUM CAROTENOID CONCENTRATIONS; OXIDATIVE STRESS; VITAMIN-D; LOWER
   PREVALENCE; NATIONAL-HEALTH; ADIPOSE-TISSUE; BETA-CAROTENE;
   NORMAL-WEIGHT; TOMATO-JUICE; ASSOCIATION
AB Cardiometabolic risk factors increase the likelihood of cardiovascular disease development by 2-fold. Lycopene, a potent lipophilic antioxidant, may be able to mediate oxidative stress, a mechanism underpinning metabolic syndrome (MetS) and its risk factors. This is, to our knowledge, the first systematic review of the literature with the purpose of investigating the relation between circulating lycopene or dietary intake of lycopene and MetS as well as its risk factors. The review was conducted using PubMed and EBSCOhost databases with the search terms "lycopene" and "metabolic syndrome." Inclusion criteria included human studies published in English in a scholarly, peer-reviewed journal and evaluation of lycopene in relation to >= 3 of the 5 MetS risk factors as defined by the National Cholesterol Education Program's Adult Treatment Panel III (ATP III) report. The process identified 11 studies, including 8 cross-sectional and 3 intervention studies. Cross-sectional studies were grouped into 3 categories, with several studies falling into>1 category, based on results reporting associations of lycopene with the prevalence and outcomes of MetS (5 studies), presence of ATP III risk factors (4 studies), and variables mediating lycopene's influence on MetS risk (3 studies). All studies in each category reported significant protective associations. Of the 3 intervention studies, all reported significant protective effects from a lycopene-rich beverage, despite varying doses and durations of intake. Although a protective relation between lycopene and MetS was generally supported, different MetS components appeared to be influenced by lycopene rather than demonstrating consistent improvement in a single component. Thus, additional research is needed to elucidate the mechanistic effects of lycopene on MetS, as well as to determine evidence-based recommendations concerning dose-durational effects of lycopene and MetS risk reduction. In conclusion, the evidence of lycopene's benefit exists such that lycopene status or lycopene consumption may be associated with favorable alterations to the components of MetS.
C1 [Senkus, Katelyn E.; Tan, Libo; Crowe-White, Kristi M.] Univ Alabama, Dept Human Nutr, Tuscaloosa, AL 35487 USA.
C3 University of Alabama System; University of Alabama Tuscaloosa
RP Crowe-White, KM (corresponding author), Univ Alabama, Dept Human Nutr, Tuscaloosa, AL 35487 USA.
EM kcrowe@ches.ua.edu
OI Tan, Libo/0000-0001-7374-9942; Senkus, Katelyn/0000-0002-1711-398X;
   Crowe-White, Kristi/0000-0003-2497-4582
CR Academy of Nutrition and Dietetics, 2016, EV AN MAN
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NR 52
TC 40
Z9 42
U1 2
U2 27
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 2161-8313
EI 2156-5376
J9 ADV NUTR
JI Adv. Nutr.
PD JAN
PY 2019
VL 10
IS 1
BP 19
EP 29
DI 10.1093/advances/nmy069
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA HK9KP
UT WOS:000458310600003
PM 30475939
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Masha, A
   Martina, V
AF Masha, A.
   Martina, V.
TI Endothelial Dysfunction in Metabolic Diseases: Role of Oxidation and
   Possible Therapeutic Employment of N-acetylcysteine
SO CURRENT MEDICINAL CHEMISTRY
LA English
DT Article
DE Antioxidants; cGMP; diabetes mellitus; metabolic syndrome; nitric oxide;
   N-acetylcysteine; oxidation; oxidative stress; polycystic ovary
   syndrome; thiols; obesity
ID POLYCYSTIC-OVARY-SYNDROME; NITRIC-OXIDE SYNTHASE; TYPE-2
   DIABETES-MELLITUS; SPONTANEOUSLY HYPERTENSIVE-RATS;
   PLASMINOGEN-ACTIVATOR INHIBITOR-1; INSULIN-RESISTANCE SYNDROME;
   CELL-ADHESION MOLECULE-1; VASCULAR SMOOTH-MUSCLE; NECROSIS-FACTOR-ALPHA;
   C-REACTIVE PROTEIN
AB Several metabolic diseases present a high cardiovascular mortality due to endothelial dysfunction consequences. In the last years of the past century, it has come to light that the endothelial cells, previously considered as inert in what regards an eventual secretion activity, play a pivotal role in regulating different aspects of the vascular function (endothelial function). It was clearly demonstrated that the endothelium acts as a real active organ, owning endocrine, paracrine and autocrine modulation activities by means of which it is able to regulate the vascular homeostasis. The present review will investigate the relationship between some metabolic diseases and the endothelial dysfunction and in particular the mechanisms underlying the effects of metabolic pathologies on the endothelium. Furthermore, it will consider the possible therapeutic employment of the N-acetilcysteine in such conditions.
C1 [Masha, A.; Martina, V.] Univ Turin, Dept Med Sci, Div Endocrinol Diabetol & Metab, I-10124 Turin, Italy.
C3 University of Turin
RP Masha, A (corresponding author), Univ Turin, Dept Med Sci, Div Endocrinol Diabetol & Metab, I-10124 Turin, Italy.
EM andi.masha@outlook.com; valentino.martina@unito.it
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NR 281
TC 6
Z9 6
U1 2
U2 11
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 0929-8673
EI 1875-533X
J9 CURR MED CHEM
JI Curr. Med. Chem.
PY 2014
VL 21
IS 32
BP 3616
EP 3635
DI 10.2174/0929867321666140706132900
PG 20
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Pharmacology &
   Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
GA AQ9IX
UT WOS:000343166500002
PM 25005185
DA 2025-06-11
ER

PT J
AU Bhuiyan, AR
   Payton, M
   Mitra, AK
   Leggett, SS
   Xu, JH
   Tchounwou, PB
   Smart, F
AF Bhuiyan, Azad R.
   Payton, Marinelle
   Mitra, Amal K.
   Leggett, Sophia S.
   Xu, Jihua
   Tchounwou, Paul B.
   Smart, Frank
TI Progression of Metabolic Syndrome Components along with Depression
   Symptoms and High Sensitivity C-Reactive Protein: The Bogalusa Heart
   Study
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Article
DE metabolic syndrome; central obesity; depression; high sensitivity
   C-reactive protein; intracellular adhesion molecule-1; Bogalusa heart
   study
ID CARDIOVASCULAR RISK; ASSOCIATION; DISEASE; HEALTH; ATHEROSCLEROSIS;
   CHILDHOOD; ADULTHOOD; OBESITY; STRESS; STATE
AB This study examined the association between depression symptoms and metabolic syndrome (MetS) or its components prospectively. It assessed the mediator role of high-sensitivity C-reactive protein (hs-CRP) and intracellular adhesion molecule-1 (ICAM-1). Self-reported depression symptoms were assessed using the Center for Epidemiologic Studies-Depression scale. MetS was defined as having at least three of the following five criteria: (1) waist circumference >102 centimeters (cm) in men or >88 cm in women; (2) triglycerides >= 50 milligrams per deciliter (mg/dL); (3) high-density lipoprotein cholesterol <40 mg/dL in men or <50 mg/dL in women; (4) blood pressure: systolic >= 30 and diastolic >= 85 mm of mercury or on antihypertensive medication; and (5) fasting glucose >= 110 mg/dL. The risk ratios (RR) with 95% confidence interval (CI) were estimated using multivariate Poisson regression models. A total of 419 White and 180 Black individuals with a mean age of 36 years were followed for 6.9 years. The findings demonstrated that hs-CRP mediated the influence of depression symptoms on central obesity in White young adults. The adjusted RR for central obesity was 1.08 with 95% CI of 0.88-1.32, and the value for hs-CRP was 1.12 with 95% CI of 1.02-1.23. Although depression did not influence MetS in this study cohort, the complete mediator role of hs-CRP was established for central obesity, a component of MetS in White young adults.
C1 [Bhuiyan, Azad R.; Payton, Marinelle; Mitra, Amal K.; Leggett, Sophia S.] Jackson State Univ, Coll Hlth Sci, Sch Publ Hlth, Jackson, MS 39213 USA.
   [Xu, Jihua; Smart, Frank] Louisiana Hlth Sci Ctr, New Orleans, LA 70112 USA.
   [Tchounwou, Paul B.] Jackson State Univ, Coll Sci Engn & Technol, Jackson, MS 39217 USA.
C3 Jackson State University; Louisiana State University System; Louisiana
   State University Health Sciences Center New Orleans; Jackson State
   University
RP Bhuiyan, AR (corresponding author), Jackson State Univ, Coll Hlth Sci, Sch Publ Hlth, Jackson, MS 39213 USA.
EM azad.r.bhuiyan@jsums.edu; marinelle.payton@jsums.edu;
   amal.k.mitra@jsums.edu; sophia.s.leggett@jsums.edu; jxu5@lsuhsc.edu;
   paul.b.tchounwou@jsums.edu; fsmart@lsuhsc.edu
OI Tchounwou, Paul/0000-0002-3407-6674; Mitra, Amal K./0000-0003-4238-7322;
   Xu, Jihua/0000-0001-5742-5964
FU National Institutes of Health, NIH [G12MD007581, U54MD015929,
   P20MD006899, HHSN268201800013I]; National Institute on Aging (NIH)
   [AG016592]
FX This researchwas supported by theNational Institutes of Health,
   NIH-GrantNo. G12MD007581 (NIMHD-RCMI Center for Environmental Health),
   NIH-Grant No. U54MD015929 (NIMHD-RCMI Center for Health Disparities
   Research), NIH-Grant No. P20MD006899 (NIMHD-Center of Excellence in
   Minority Health and Health Disparities), and NIH-Grant No.
   HHSN268201800013I (NHLBI-Jackson Heart Study Graduate Training and
   Education Center). BHS was also supported by the grant from the National
   Institute on Aging (NIH-Grant No. AG016592).
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NR 35
TC 3
Z9 3
U1 1
U2 2
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD MAY
PY 2021
VL 18
IS 9
AR 5010
DI 10.3390/ijerph18095010
PG 14
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA SB9BO
UT WOS:000650280400001
PM 34065158
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Pinna, G
AF Pinna, Graziano
TI Role of PPAR-Allopregnanolone Signaling in Behavioral and Inflammatory
   Gut-Brain Axis Communications
SO BIOLOGICAL PSYCHIATRY
LA English
DT Review
ID PROLIFERATOR-ACTIVATED RECEPTOR; PEROXISOMAL BETA-OXIDATION; HIGH-FAT
   DIET; ALPHA; STRESS; AGONIST; PATHWAY; PALMITOYLETHANOLAMIDE;
   MICROBIOTA; EXPRESSION
AB The gut microbiome regulates emotional behavior, stress responses, and inflammatory processes by communicating with the brain. How and which neurobiological mediators underlie this communication remain poorly understood. PPAR-a (peroxisome proliferator-activated receptor a), a transcription factor susceptible to epigenetic modifications, regulates pathophysiological functions, including metabolic syndrome, inflammation, and behavior. Mood disorders, inflammatory processes, and obesity are intertwined phenomena that are associated with low blood concentrations of the anti-inflammatory and "endogenous tranquilizer" neurosteroid allopregnanolone and poor PPAR-a function. Stress and consumption of obesogenic diets repress PPAR function in brain, enterocytes, lipocytes, and immune modulatory cells favoring inflammation, lipogenesis, and mood instability. Conversely, micronutrients and modulators of PPAR-a function improve microbiome composition, dampen systemic inflammation and lipogenesis, and improve anxiety and depression. In rodent stress models of anxiety and depression, PPAR activation normalizes both PPAR-a expression downregulation and decreased allopregnanolone content and ameliorates depressive-like behavior and fear responses. PPAR-a is known to regulate metabolic and inflammatory processes activated by short-chain fatty acids; endocannabinoids and congeners, such as N-palmitoylethanolamide, drugs that treat dyslipidemias; and micronutrients, including polyunsaturated fatty acids. Both PPAR-a and allopregnanolone are abundantly expressed in the colon, and they exert potent anti-inflammatory actions by blocking the toll-like receptor-4-nuclear factor-kB pathway in peripheral immune cells, neurons, and glia. The perspective that PPAR-a regulation in the colon by gut microbiota or metabolites influences central allopregnanolone content after trafficking to the brain, thereby serving as a mediator of gut-brain axis communications, is examined in this review.
C1 [Pinna, Graziano] Univ Illinois Ctr Depress & Resilience, Univ Illinois Chicago, Psychiat Inst, Chicago, IL 60607 USA.
   [Pinna, Graziano] Univ Illinois, Ctr Alcohol Res Epigenet, Dept Psychiat, Chicago, IL 60607 USA.
C3 University of Illinois System; University of Illinois Chicago;
   University of Illinois System; University of Illinois Chicago;
   University of Illinois Chicago Hospital
RP Pinna, G (corresponding author), Univ Illinois Ctr Depress & Resilience, Univ Illinois Chicago, Psychiat Inst, Chicago, IL 60607 USA.; Pinna, G (corresponding author), Univ Illinois, Ctr Alcohol Res Epigenet, Dept Psychiat, Chicago, IL 60607 USA.
EM gpinna@uic.edu
OI Pinna, Graziano/0000-0001-7541-4855
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NR 96
TC 16
Z9 16
U1 2
U2 12
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0006-3223
EI 1873-2402
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD OCT 15
PY 2023
VL 94
IS 8
BP 609
EP 618
DI 10.1016/j.biopsych.2023.04.025
EA SEP 2023
PG 10
WC Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Psychiatry
GA T7NC4
UT WOS:001079803400001
PM 37156350
DA 2025-06-11
ER

PT J
AU Olvera, RL
   Williamson, DE
   Fisher-Hoch, SP
   Vatcheva, KP
   McCormick, JB
AF Olvera, Rene L.
   Williamson, Douglas E.
   Fisher-Hoch, Susan P.
   Vatcheva, Kristina P.
   McCormick, Joseph B.
TI Depression, Obesity, and Metabolic Syndrome: Prevalence and Risks of
   Comorbidity in a Population-Based Representative Sample of Mexican
   Americans
SO JOURNAL OF CLINICAL PSYCHIATRY
LA English
DT Article
DE Comorbidity; Cross-Cultural Psychiatry; Depression; Metabolic Disorders;
   Weight
ID 3RD NATIONAL-HEALTH; MAJOR DEPRESSION; INSULIN-RESISTANCE;
   GENDER-DIFFERENCES; HDL CHOLESTEROL; US ADULTS; CES-D; ASSOCIATION;
   ADOLESCENTS; OVERWEIGHT
AB Introduction: We examined the prevalence of depression, obesity, and metabolic syndrome and associations between them in a population-based representative cohort of Mexican Americans living on the United States-Mexico border.
   Method: The sample in this cross-sectional analysis consisted of 1,768 Mexican American adults (>= 18 years of age) assessed between the years 2004 and 2010, with whom we tested our central hypothesis of a significant relationship between obesity and depression. Depression was measured using the Center for Epidemiologic Studies-Depression scale (CES-D) with a cutoff score of >= 16 for depression and a cutoff score of >= 27 for severe depression. We categorized body mass index (BMI) values as obese (>= 30kg/m(2)) and later subdivided the obese subjects into obese (30-39 kg/m(2)[inclusive]) and morbidly obese (>= 40 kg/m(2)). Metabolic syndrome was defined using the American Heart Association definition requiring at least 3 of the following: increased waist circumference, elevated triglycerides, reduced high-density lipoprotein (HDL) cholesterol, elevated blood pressure, and elevated fasting glucose. Weighted data were analyzed to establish prevalence of depression, obesity, and metabolic syndrome. Univariate and multivariable weighted regression models were used to test potential associations between these disorders.
   Results: Using weighted prevalence, we observed high rates of depression (30%), obesity (52%), and metabolic syndrome (45%). Univariate models revealed female gender (P = .0004), low education (P = .003), low HDL level (P = .009), and increased waist circumference (P = .03) were associated with depression. Female gender (P = .01), low education (P = .003), and morbid obesity (P = .002) were risk factors for severe depression and remained significant in multivariable models.
   Conclusions: In this large cohort of Mexican Americans, obesity, female gender, and low education were identified risk factors for depression. These indicators may serve as targets for early detection, prevention, and intervention in this population.
C1 [Olvera, Rene L.; Williamson, Douglas E.] Univ Texas Hlth Sci Ctr San Antonio, Dept Psychiat, San Antonio, TX 78229 USA.
   [Fisher-Hoch, Susan P.; Vatcheva, Kristina P.; McCormick, Joseph B.] Univ Texas Hlth Sci Ctr Houston, Sch Publ Hlth, Div Epidemiol, Brownsville, TX USA.
C3 University of Texas System; University of Texas Health Science Center at
   San Antonio; University of Texas System; University of Texas Health
   Science Center Houston
RP Olvera, RL (corresponding author), Univ Texas Hlth Sci Ctr San Antonio, Dept Psychiat, 7703 Floyd Curl Dr, San Antonio, TX 78229 USA.
EM olverar@UTHSCSA.edu
RI Williamson, Ethel/AAQ-8878-2020
OI McCormick, Joseph/0000-0002-5844-8102; Williamson,
   Douglas/0000-0002-5310-1716; Vatcheva, Kristina/0000-0002-7260-2524
FU National Institute on Minority Health and Health Disparities [MD000170
   P20]; Centers for Clinical and Translational Science Award from the
   National Center for Research Resources, Washington DC [UL1 TR000371]
FX This work was supported by MD000170 P20, which was funded by the
   National Institute on Minority Health and Health Disparities, and by the
   Centers for Clinical and Translational Science Award UL1 TR000371 from
   the National Center for Research Resources, Washington DC.
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NR 69
TC 38
Z9 50
U1 0
U2 22
PU PHYSICIANS POSTGRADUATE PRESS
PI MEMPHIS
PA P O BOX 752870, MEMPHIS, TN 38175-2870 USA
SN 0160-6689
EI 1555-2101
J9 J CLIN PSYCHIAT
JI J. Clin. Psychiatry
PD OCT
PY 2015
VL 76
IS 10
BP E1300
EP E1305
DI 10.4088/JCP.14m09118
PG 6
WC Psychology, Clinical; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA DB2OC
UT WOS:000368347900007
PM 26528653
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Zheng, JQ
   Liu, XH
   Zheng, BB
   Zheng, ZZ
   Zhang, HP
   Zheng, JY
   Sun, CC
   Chen, HY
   Yang, J
   Wang, Z
   Lin, MM
   Chen, JJ
   Zhou, QD
   Zheng, Z
   Xu, XM
   Ying, H
AF Zheng, Jianqiong
   Liu, Xiaohui
   Zheng, Bingbing
   Zheng, Zhenzhen
   Zhang, Hongping
   Zheng, Jiayong
   Sun, Congcong
   Chen, Haiying
   Yang, Jie
   Wang, Zuo
   Lin, Meimei
   Chen, Jingjing
   Zhou, Qingdiao
   Zheng, Zhi
   Xu, Xiaoming
   Ying, Hao
TI Maternal 25-Hydroxyvitamin D Deficiency Promoted Metabolic Syndrome and
   Downregulated Nrf2/CBR1 Pathway in Offspring
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Article
DE maternal; 25-hydroxyvitamin D deficiency; metabolic syndrome; Nrf2; CBR1
   pathway; offspring
ID VITAMIN-D DEFICIENCY; OXIDATIVE STRESS; INSULIN-RESISTANCE; NRF2;
   INFLAMMATION; ACTIVATION; ACCUMULATION; OBESITY; CANCER
AB Metabolic syndrome is a disorder of energy use and storage, which is characterized by central obesity, dyslipidemia, and raised blood pressure and blood sugar levels. Maternal 25-hydroxyvitamin D de?ciency is known to cause metabolic changes, chronic disease, and increased adiposity in adulthood. However, the underlying mechanism of induced metabolic syndrome (MetS) in the offspring in vitamin D deficient pregnant mothers remains unclear. We identified that maternal 25-hydroxyvitamin D deficiency enhances oxidative stress, which leads to the development of MetS in the mother and her offspring. Further, immunohistochemical, Western blotting, and qRT-PCR analyses revealed that maternal 25-hydroxyvitamin D deficiency inhibited the activation of the Nrf2/carbonyl reductase 1 (CBR1) pathway in maternal placenta, liver, and pancreas, as well as the offspring's liver and pancreas. Further analyses uncovered that application of 25-hydroxyvitamin D activated the Nrf2/CBR1 pathway, relieving the oxidative stress in BRL cells, suggesting that 25-hydroxyvitamin D regulates oxidative stress in offspring and induces the activation of the Nrf2/CBR1 pathway. Taken together, our study finds that maternal 25-hydroxyvitamin D deficiency is likely to result in offspring's MetS probably via abnormal nutrition transformation across placenta. Depression of the Nrf2/CBR1 pathway in both mothers and their offspring is one of the causes of oxidative stress leading to MetS. This study suggests that 25-hydroxyvitamin D treatment may relieve the offspring's MetS.
C1 [Zheng, Jianqiong; Liu, Xiaohui; Ying, Hao] Tongji Univ, Shanghai Matern & Infant Hosp 1, Sch Med, Dept Obstet, Shanghai, Peoples R China.
   [Zheng, Jianqiong; Zheng, Bingbing; Zheng, Zhenzhen; Zhang, Hongping; Chen, Haiying; Yang, Jie; Wang, Zuo; Lin, Meimei; Chen, Jingjing; Zhou, Qingdiao; Zheng, Zhi] Wenzhou Med Univ, Clin Inst 3, Wenzhou Peoples Hosp, Dept Obstet & Gynecol, Wenzhou, Peoples R China.
   [Zheng, Jiayong; Sun, Congcong; Xu, Xiaoming] Wenzhou Med Univ, Clin Inst 3, Wenzhou Peoples Hosp, Dept Wenzhou,Key Lab Gynecol & Obstet, Wenzhou, Peoples R China.
C3 Tongji University; Wenzhou Medical University; Wenzhou Medical
   University
RP Ying, H (corresponding author), Tongji Univ, Shanghai Matern & Infant Hosp 1, Sch Med, Dept Obstet, Shanghai, Peoples R China.
EM stephenying_2011@163.com
RI Congcong, Sun/JRC-1498-2023; ying, hao/J-6540-2017; Xu,
   Xiaoming/S-1512-2018
FU Natural Science Foundation of Zhejiang Province [LY13H040010,
   LQ18H040002]
FX This work was supported by the Natural Science Foundation of Zhejiang
   Province under Grant No. LY13H040010, LQ18H040002.
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NR 40
TC 12
Z9 12
U1 0
U2 7
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD FEB 28
PY 2020
VL 11
AR 97
DI 10.3389/fphar.2020.00097
PG 14
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA LC4SN
UT WOS:000525314200001
PM 32184720
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Bortolasci, CC
   Vargas, HO
   Souza-Nogueira, A
   Moreira, EG
   Nunes, SOV
   Berk, M
   Dodd, S
   Barbosa, DS
   Maes, M
AF Bortolasci, Chiara Cristina
   Vargas, Heber Odebrecht
   Souza-Nogueira, Andre
   Moreira, Estefania Gastaldello
   Vargas Nunes, Sandra Odebrecht
   Berk, Michael
   Dodd, Seetal
   Barbosa, Decio Sabbatini
   Maes, Michael
TI Paraoxonase (PON)1 Q192R functional genotypes and PON1 Q192R genotype by
   smoking interactions are risk factors for the metabolic syndrome, but
   not overweight or obesity
SO REDOX REPORT
LA English
DT Article
DE Paraoxonase 1; Metabolic syndrome; Depression; HDL cholesterol;
   Oxidative stress; Cardiovascular
ID GENE POLYMORPHISMS; MAJOR DEPRESSION; ANTIOXIDANT PARAOXONASE-1;
   CARDIOVASCULAR RISK; OXIDATIVE STRESS; DISEASE; ASSOCIATION;
   INFLAMMATION; SYMPTOMS; DISORDER
AB Background: The metabolic syndrome (MetS) is a complex of multiple risk factors that contribute to the onset of cardiovascular disorder, including lowered levels of high-density lipoprotein (HDL) and abdominal obesity. Smoking, mood disorders, and oxidative stress are associated with the MetS. Paraoxonase (PON) 1 is an antioxidant bound to HDL, that is under genetic control by functional polymorphisms in the PON1 Q192R coding sequence.
   Aims and methods: This study aimed to delineate the associations of the MetS with plasma PON1 activity, PON1 Q192R genotypes, smoking, and mood disorders (major depression and bipolar disorder), while adjusting for HDL cholesterol, body mass index, age, gender, and sociodemographic data. We measured plasma PON1 activity and serum HDL cholesterol and determined PON1 Q192R genotypes through functional analysis in 335 subjects, consisting of 97 with and 238 without MetS. The severity of nicotine dependence was measured using the Fagerstrom Nicotine Dependence Scale.
   Results: PON1 Q192R functional genotypes and PON1 Q192R genotypes by smoking interactions were associated with the MetS. The QQ and QR genotypes were protective against MetS while smoking increased metabolic risk in QQ carriers only. There were no significant associations between PON1 Q192R genotypes and smoking by genotype interactions and obesity or overweight, while body mass index significantly increased MetS risk. Smoking and especially severe nicotine dependence are significantly associated with the MetS although these effects were no longer significant after considering the effects of the smoking by PON1 Q192R genotype interaction. The MetS was not associated with mood disorders, major depression or bipolar disorder.
   Discussion: PON1 Q192R genotypes and genotypes by smoking interactions are risk factors for the MetS that together with lowered HDL and increased body mass and age contribute to the MetS.
C1 [Bortolasci, Chiara Cristina; Souza-Nogueira, Andre] Univ Estadual Londrina, Univ Hosp, Lab Grad Res, Londrina, Parana, Brazil.
   [Vargas, Heber Odebrecht; Vargas Nunes, Sandra Odebrecht] Univ Estadual Londrina, Hlth Sci Ctr, Dept Psychiat, Londrina, Parana, Brazil.
   [Moreira, Estefania Gastaldello] Univ Estadual Londrina, Dept Psychol Sci, Londrina, Parana, Brazil.
   [Berk, Michael; Dodd, Seetal; Maes, Michael] Deakin Univ, IMPACT Strateg Res Ctr, Sch Med, Geelong, Vic 3220, Australia.
   [Berk, Michael; Dodd, Seetal] Univ Melbourne, Orygen Youth Hlth Res Ctr, Dept Psychiat, Parkville, Vic 3052, Australia.
   [Berk, Michael; Dodd, Seetal] Univ Melbourne, Florey Inst Neurosci & Mental Hlth, Parkville, Vic 3052, Australia.
   [Barbosa, Decio Sabbatini] Univ Estadual Londrina, Dept Pathol Clin & Toxicol Anal, Londrina, Parana, Brazil.
   [Maes, Michael] Chulalongkorn Univ, Fac Med, Dept Psychiat, Bangkok 10330, Thailand.
   [Maes, Michael] Univ Estadual Londrina, Hlth Sci Ctr, Hlth Sci Grad Program, Londrina, PR, Brazil.
C3 Universidade Estadual de Londrina; Universidade Estadual de Londrina;
   Universidade Estadual de Londrina; Deakin University; University of
   Melbourne; Orygen, The National Centre of Excellence in Youth Mental
   Health; University of Melbourne; Florey Institute of Neuroscience &
   Mental Health; Universidade Estadual de Londrina; Chulalongkorn
   University; Universidade Estadual de Londrina
RP Maes, M (corresponding author), Deakin Univ, IMPACT Strateg Res Ctr, Sch Med, POB 281, Geelong, Vic 3220, Australia.
EM dr.michaelmaes@hotmail.com
RI Nunes, Sandra/B-4035-2019; Moreira, Estefania/AAC-5959-2019; Berk,
   Michael/AGH-9427-2022; Barbosa, Décio/AAE-6351-2019; Maes,
   Michael/B-8546-2011; Berk, Michael/M-7891-2013; Bortolasci,
   Chiara/C-7336-2016
OI Moreira, Estefania/0000-0001-8362-9557; Dodd,
   Seetal/0000-0002-7918-4636; Berk, Michael/0000-0002-5554-6946;
   Bortolasci, Chiara/0000-0002-0794-6363
FU NHMRC Senior Principal Research Fellowship; Fundacao Araucaria/SETI
FX M.B. is supported by a NHMRC Senior Principal Research Fellowship and
   E.G.M. by a senior fellowship from Fundacao Araucaria/SETI.
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NR 59
TC 5
Z9 5
U1 0
U2 8
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1351-0002
EI 1743-2928
J9 REDOX REP
JI Redox Rep.
PD NOV
PY 2014
VL 19
IS 6
BP 232
EP 241
DI 10.1179/1351000214Y.0000000093
PG 10
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA AR0DW
UT WOS:000343238300002
PM 25037113
OA Green Published
DA 2025-06-11
ER

PT J
AU Gao, YN
   Olfson, M
AF Gao, Y. Nina
   Olfson, Mark
TI National trends in metabolic risk of psychiatric inpatients in the
   United States during the atypical antipsychotic era
SO SCHIZOPHRENIA RESEARCH
LA English
DT Article
DE Schizophrenia; Side effects-medication; Metabolic syndrome; Type 2
   diabetes
ID WEIGHT-GAIN; SCHIZOPHRENIA; PREVALENCE; ABNORMALITIES; FUTURE; ADULTS;
   DEATH; MODEL
AB Although the cardiometabolic effects of atypical antipsychotics have been well-described in clinical samples, less is known about the longer-term impacts of these treatments. We report rates of metabolic syndrome in a na-tionally representative sample of U.S. adult inpatients 1993-2018 admitted for schizophrenia-spectrum disorders (n = 1,785,314), any mental health disorder (n = 8,378,773), or neither (n = 14,458,616) during a period of widespread atypical antipsychotic use. Metabolic syndrome, derived from additional diagnoses, was defined as three or more of hypertension, dyslipidemia, type II diabetes, hyperglycemia, and overweight or obese. Using an ecological age and period design, a 4-level period variable was constructed to proxy for atypical antipsychotic exposure as the minimum of age minus 20 years or the calendar year minus 1997 in accord with the disease course for schizophrenia-spectrum illness and the market share of atypical antipsychotics in the U.S. Logistic regression models, adjusted for age, year, and exposure main effects, estimated odds ratios (ORs) of metabolic syndrome. Relative to other mental health or other discharges, schizophrenia-spectrum discharges had an elevated risk for metabolic syndrome regardless of potential atypical antipsychotic exposure (OR = 1.46; 95 % CI, 1.30-1.64). For schizophrenia-spectrum discharges, periods of potential atypical antipsychotic exposure conferred additional metabolic syndrome risk OR = 1.21; 95 % CI, 1.04-1.41 for exposures of 1-2 years, OR = 1.29; 95 % CI, 1.13-1.46 for 3-7 years, OR = 1.27; 95 % CI, 1.12-1.44 for 8-12 years, and OR = 1.10; 95 % CI 0.98-1.24 for >12 years. In summary, cardiometabolic disease and related risks were elevated among a na-tionally representative sample of adult inpatients with schizophrenia-spectrum disorders during a period of pervasive atypical antipsychotic use.
C1 [Gao, Y. Nina; Olfson, Mark] Columbia Univ, Vagelos Coll Phys & Surg, Dept Psychiat, New York, NY 10027 USA.
   [Gao, Y. Nina; Olfson, Mark] New York State Psychiat Inst & Hosp, New York, NY 10032 USA.
   [Olfson, Mark] Columbia Univ, Mailman Sch Publ Hlth, Dept Epidemiol, New York, NY USA.
C3 Columbia University; New York State Psychiatry Institute; Columbia
   University
RP Gao, YN (corresponding author), Columbia Univ, Vagelos Coll Phys & Surg, Dept Psychiat, New York, NY 10027 USA.; Gao, YN (corresponding author), New York State Psychiat Inst & Hosp, New York, NY 10032 USA.
EM yihe.gao@nyspi.columbia.edu
RI Olfson, Mark/AAA-8547-2021
OI Gao, Yihe/0000-0003-4058-607X
FU Moynihan Clinical Research Fellowship from the Leon Levy Foundation;
   National Institute of Mental Health;  [R25MH086466]; National Institute
   of Mental Health [R25MH086466] Funding Source: NIH RePORTER
FX YNG was supported in part by a Moynihan Clinical Research Fellowship
   from the Leon Levy Foundation and Award Number R25MH086466 from the
   National Institute of Mental Health.
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NR 56
TC 5
Z9 5
U1 0
U2 1
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0920-9964
EI 1573-2509
J9 SCHIZOPHR RES
JI Schizophr. Res.
PD OCT
PY 2022
VL 248
BP 320
EP 328
DI 10.1016/j.schres.2022.09.023
EA SEP 2022
PG 9
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 5A1VY
UT WOS:000862683100022
PM 36155305
OA Bronze, Green Accepted
DA 2025-06-11
ER

PT J
AU Veitch, DP
   Friedl, KE
   Weiner, MW
AF Veitch, Dallas P.
   Friedl, Karl E.
   Weiner, Michael W.
TI Military Risk Factors for Cognitive Decline, Dementia and Alzheimer's
   Disease
SO CURRENT ALZHEIMER RESEARCH
LA English
DT Article
DE Alzheimer's disease; armed forces; combat; depression; gulf war illness;
   post-traumatic stress disorder; risk factors; traumatic brain injury
ID TRAUMATIC BRAIN-INJURY; POSTTRAUMATIC-STRESS-DISORDER; GULF-WAR
   VETERANS; MENTAL-HEALTH PROBLEMS; QUALITY-OF-LIFE; PERSISTENT ORGANIC
   POLLUTANTS; AMYLOID PROTEIN DEPOSITION; MAJOR DEPRESSIVE DISORDER;
   CORONARY-HEART-DISEASE; CHRONIC KIDNEY-DISEASE
AB Delayed neurological health consequences of environmental exposures during military service have been generally underappreciated. The rapidly expanding understanding of Alzheimer's disease (AD) pathogenesis now makes it possible to quantitate some of the likely long-term health risks associated with military service. Military risk factors for AD include both factors elevated in military personnel such as tobacco use, traumatic brain injury (TBI), depression, and post-traumatic stress disorder (PTSD) and other nonspecific risk factors for AD including, vascular risk factors such as obesity and obesity-related diseases (e.g., metabolic syndrome), education and physical fitness. The degree of combat exposure, Vietnam era Agent Orange exposure and Gulf War Illness may also influence risk for AD. Using available data on the association of AD and specific exposures and risk factors, the authors have conservatively estimated 423,000 new cases of AD in veterans by 2020, including 140,000 excess cases associated with specific military exposures. The cost associated with these excess cases is approximately $5.8 billion to $7.8 billion. Mitigation of the potential impact of military exposures on the cognitive function of veterans and management of modifiable risk factors through specifically designed programs will be instrumental in minimizing the impact of AD in veterans in the future decades.
C1 [Veitch, Dallas P.; Weiner, Michael W.] Univ Calif San Francisco, Ctr Imaging Neurodegenerat Dis, Ctr Vet Med, San Francisco, CA 94143 USA.
   [Friedl, Karl E.] US Army Med Res & Mat Command, Telemed & Adv Technol Res Ctr, Ft Detrick, MD USA.
   [Weiner, Michael W.] Univ Calif San Francisco, Dept Radiol, San Francisco, CA 94143 USA.
   [Weiner, Michael W.] Univ Calif San Francisco, Dept Med, San Francisco, CA USA.
   [Weiner, Michael W.] Univ Calif San Francisco, Dept Psychiat, San Francisco, CA USA.
   [Weiner, Michael W.] Univ Calif San Francisco, Dept Neurol, San Francisco, CA USA.
C3 University of California System; University of California San Francisco;
   United States Department of Defense; United States Army; University of
   California System; University of California San Francisco; University of
   California System; University of California San Francisco; University of
   California System; University of California San Francisco; University of
   California System; University of California San Francisco
RP Weiner, MW (corresponding author), Univ Calif San Francisco, Ctr Imaging Neurodegenerat Dis, Ctr Vet Med, San Francisco, CA 94143 USA.
EM michael.weiner@ucsf.edu
RI Friedl, Karl/M-1803-2019
OI Friedl, Karl/0000-0002-3134-8427; Veitch, Dallas/0000-0002-9918-0640
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PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1567-2050
EI 1875-5828
J9 CURR ALZHEIMER RES
JI Curr. Alzheimer Res.
PD NOV
PY 2013
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BP 907
EP 930
DI 10.2174/15672050113109990142
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WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
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DA 2025-06-11
ER

PT J
AU Babic, D
   Jakovljevic, M
   Martinac, M
   Saric, M
   Topic, R
   Maslov, B
AF Babic, Dragan
   Jakovljevic, Miro
   Martinac, Marko
   Saric, Marija
   Topic, Radmila
   Maslov, Boris
TI Metabolic syndrome and combat post-traumatic stress disorder intensity:
   Preliminary findings
SO PSYCHIATRIA DANUBINA
LA English
DT Article
DE combat posttraumatic stress disorder intensity; war veterans; metabolic
   syndrome
ID BODY-MASS INDEX; INSULIN-RESISTANCE; VETERANS; ILLNESS
AB Background: Post-traumatic stress disorder (PTSD) has been associated with co-morbidity of many major mental and somatic disorders as well as with premature mortality.
   Objective: The objective of this study was to examine the relationship between combat-related PTSD, metabolic syndrome and its components as well as between PTSD severity and metabolic syndrome.
   Methods: Metabolic syndrome and its components were investigated in 100 male war veterans with combat PTSD and in 79 males who needed medical attention in a family medicine dispensary.
   Results: Metabolic syndrome according to the modified NCEP: ATP III criteria was found in 35% of our PTSD patients. Metabolic syndrome and intensity of PTSD were significantly related. Metabolic syndrome was identified in 66.7% of the war veterans with high intensity of PTSD in comparison to 23.3% of the veterans with low intensity PTSD.
   Conclusions: Prevalence of metabolic syndrome and its components is elevated in war veterans with PTSD. PTSD is a multi-systemic disorder and treatment of war veterans with PTSD should address co-morbid somatic disorders including metabolic syndrome in addition to the clinical features of PTSD.
C1 [Babic, Dragan; Jakovljevic, Miro; Martinac, Marko; Maslov, Boris] Univ Mostar, Dept Psychiat, Sch Med, Mostar, Bosnia & Herceg.
   [Jakovljevic, Miro; Saric, Marija; Topic, Radmila] Univ Zagreb, Clin Hosp Ctr, Univ Psychiat Clin Rebro, Zagreb 10000, Croatia.
C3 University of Mostar; University of Zagreb
RP Jakovljevic, M (corresponding author), Univ Mostar, Dept Psychiat, Sch Med, Mostar, Bosnia & Herceg.
EM miro.jakovljevic@mef.hr
CR Bakker SJL, 2007, NEPHROL DIAL TRANSPL, V22, P15, DOI 10.1093/ndt/gfl581
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   Gander ML, 2006, EUR J CARDIOV PREV R, V13, P165, DOI 10.1097/01.hjr.0000214606.60995.46
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NR 33
TC 36
Z9 37
U1 0
U2 5
PU MEDICINSKA NAKLADA
PI ZAGREB
PA VLASKA 69, HR-10000 ZAGREB, CROATIA
SN 0353-5053
EI 1849-0867
J9 PSYCHIAT DANUB
JI Psychiatr. Danub.
PD JUN
PY 2007
VL 19
IS 1-2
BP 68
EP 75
PG 8
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 270GV
UT WOS:000253710100011
PM 17603419
DA 2025-06-11
ER

PT J
AU Dregan, A
   Rayner, L
   Davis, KAS
   Bakolis, I
   de la Torre, JA
   Das-Munshi, J
   Hatch, SL
   Stewart, R
   Hotopf, M
AF Dregan, Alex
   Rayner, Lauren
   Davis, Katrina A. S.
   Bakolis, Ioannis
   de la Torre, Jorge Arias
   Das-Munshi, Jayati
   Hatch, Stephani L.
   Stewart, Robert
   Hotopf, Matthew
TI Associations Between Depression, Arterial Stiffness, and Metabolic
   Syndrome Among Adults in the UK Biobank Population Study: A Mediation
   Analysis
SO JAMA PSYCHIATRY
LA English
DT Article
ID PULSE-WAVE VELOCITY; C-REACTIVE PROTEIN; ENDOTHELIAL FUNCTION;
   CARDIOVASCULAR-DISEASE; MYOCARDIAL-INFARCTION; ABDOMINAL OBESITY;
   BLOOD-PRESSURE; RISK-FACTORS; HEALTH; PREVALENCE
AB Key PointsQuestionTo what extent is the association of depression with peripherally assessed arterial stiffness mediated by metabolic syndrome? FindingsIn this large population-based cohort study of 124445 adults aged 40 to 69 years, up to one-third of the association of depression with arterial stiffness was mediated by metabolic syndrome. The addition of inflammation to metabolic syndrome further increased the proportion of the mediated association of depression with arterials stiffness. MeaningCombined data on metabolic syndrome and inflammation may improve the early identification of future cardiovascular risk among adult patients with depression.
   This cohort study assesses the association of depression with elevated midlife arterial stiffness and investigates the extent to which this association is mediated by metabolic syndrome.
   ImportancePrevious research has linked a history of depression with arterial stiffness (AS) during midlife. ObjectiveTo assess the association of depression with elevated midlife AS and to investigate the extent to which this association is mediated via metabolic syndrome (MetS). Design, Settings, and ParticipantsThis population-based retrospective cohort study analyzed data collected between March 2006 and December 2010 from 124445 participants aged 40 to 69 years from the UK Biobank. Participants without data on AS at baseline (n=332780) or who reported a previous diagnosis of cardiovascular disease (n=45374) were not eligible. Data analysis was performed from May to August 2019. ExposuresLifetime history of depression was assessed via verbal interview and linked hospital-based clinical depression diagnosis. Metabolic syndrome was defined as the presence of 3 or more of hypertension, dyslipidemia, hyperglycemia, hypertriglyceridemia, and unhealthy waist circumference. Main Outcomes and MeasuresPeripherally assessed AS index (ASI) using digital photoplethysmography. ResultsOf 124445 included participants with ASI assessed, 71799 (57.7%) were women, and the mean (SD) age was 56 (8) years. A total of 10304 participants (8.3%) reported a history of depression. Study findings indicated a significant direct association between depression and ASI levels (beta =0.25; 95% CI, 0.17-0.32). A significant indirect association was also observed between depression and ASI levels (beta =0.10; 95% CI, 0.07-0.13), indicating that 29% of the association of depression with ASI was mediated by MetS. The proportion of mediation increased to 37% when C-reactive protein was added to the MetS criteria (direct association: beta =0.21; 95% CI, 0.15-0.28; indirect association: beta =0.13; 95% CI, 0.10-0.17). Concerning components of MetS, the strongest indirect association was for waist circumference, accounting for 25% of the association between depression and ASI levels (direct association: beta =0.26; 95% CI, 0.18-0.34; indirect association: beta =0.09; 95% CI, 0.06-0.11). Among men, hypertriglyceridemia accounted for 19% of the association between depression and ASI (direct association: beta =0.22; 95% CI, 0.05-0.40; indirect association: beta =0.05; 95% CI, 0.02-0.08). Conclusions and RelevanceOne-third of the association of depression with elevated ASI levels during midlife may be accounted for by combined MetS and inflammatory processes. Unhealthy waist circumference and hypertriglyceridemia emerged as the most important potential targets for preventive interventions within women and men, respectively.
C1 [Dregan, Alex; Rayner, Lauren; Davis, Katrina A. S.; de la Torre, Jorge Arias; Das-Munshi, Jayati; Hatch, Stephani L.; Stewart, Robert; Hotopf, Matthew] Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Psychol Med, De Crespigny Pk, London SES 8AF, England.
   [Bakolis, Ioannis] Kings Coll London, Inst Psychiat Psychol Arid Neurosci, Biostat & Hlth Informat, London, England.
   [Bakolis, Ioannis] Kings Coll London, Ctr Implementat Sci, Inst Psychiat Psychol & Neurosci, Hlth Serv & Populat Res Dept, London, England.
   [Stewart, Robert; Hotopf, Matthew] South London & Maudsley NHS Fdn Trust, London, England.
C3 University of London; King's College London; University of London;
   King's College London; South London & Maudsley NHS Trust
RP Dregan, A (corresponding author), Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Psychol Med, De Crespigny Pk, London SES 8AF, England.
EM alexandru.dregan@kcl.ac.uk
RI Hatch, Stephani/B-4235-2010; Stewart, Robert/B-1667-2010; Hotopf,
   Matthew/E-4971-2010; Das-Munshi, Jayati/F-1910-2010
OI Davis, Katrina/0000-0001-5945-4646; Hotopf, Matthew/0000-0002-3980-4466;
   Bakolis, Ioannis/0000-0002-4800-1630; Rayner,
   Lauren/0000-0003-4481-0331; Das-Munshi, Jayati/0000-0002-3913-6859; ,
   Jorge/0000-0001-6908-9611; Dregan, Alex/0000-0002-7620-4902; Hatch,
   Stephani/0000-0001-9103-2427
FU National Institute for Health Research Biomedical Research Centre at
   South London and Maudsley NHS Foundation Trust; Medical Research Council
   [MR/S028188/1]; National Institute for Health Research Collaboration for
   Leadership in Applied Health Research and Care South London at King's
   College London NHS Foundation Trust; King's College London; EPSRC
   [EP/N027280/1] Funding Source: UKRI; ESRC [ES/S012567/1] Funding Source:
   UKRI; MRC [MC_PC_17214, MC_PC_12028, MR/S028188/1, MR/T045302/1] Funding
   Source: UKRI
FX This article was partially funded by the National Institute for Health
   Research Biomedical Research Centre at South London and Maudsley NHS
   Foundation Trust and King's College London. Drs Dregan and Arias de la
   Torre are supported by grant MR/S028188/1 from the Medical Research
   Council. Dr Bakolis is funded by the National Institute for Health
   Research Collaboration for Leadership in Applied Health Research and
   Care South London at King's College London NHS Foundation Trust.
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NR 61
TC 86
Z9 90
U1 4
U2 33
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 2168-622X
EI 2168-6238
J9 JAMA PSYCHIAT
JI JAMA Psychiatry
PD JUN
PY 2020
VL 77
IS 6
BP 598
EP 606
DI 10.1001/jamapsychiatry.2019.4712
PG 9
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA MW1HB
UT WOS:000556796000009
PM 31995135
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Pérez-Torres, I
   Roque, P
   El Hafidi, M
   Diaz-Diaz, E
   Baños, G
AF Perez-Torres, Israel
   Roque, Priscilla
   El Hafidi, Mohammed
   Diaz-Diaz, Eulises
   Banos, Guadalupe
TI Association of renal damage and oxidative stress in a rat model of
   metabolic syndrome. Influence of gender
SO FREE RADICAL RESEARCH
LA English
DT Article
DE Rat metabolic syndrome; renal damage; antioxidants; sex hormones
ID SPONTANEOUSLY HYPERTENSIVE-RATS; CORONARY-HEART-DISEASE; HIGH SUCROSE
   DIET; ENDOTHELIAL DYSFUNCTION; SUPEROXIDE-DISMUTASE; SEX-HORMONES;
   VASCULAR REACTIVITY; BLOOD-PRESSURE; IN-VITRO; FRUCTOSE
AB This study investigated the association between nephropathy and oxidative stress, by measurement of systolic blood pressure, lipid peroxidation, activities of catalase, manganese- and copper-zinc-superoxide dismutase and endothelial nitric oxide synthase expression and concentrations of nitrates/nitrites in kidneys from rats with Metabolic Syndrome. Weaning female or male rats had 30% sucrose to drink for 24 weeks (Metabolic Syndrome). Modulation by sex hormones was investigated by gonadectomy and hormone replacement. In Metabolic Syndrome, Castrated Metabolic Syndrome + Testosterone males and Ovariectomized Metabolic Syndrome females had increased blood pressure, proteinuria and lipid peroxidation. Nitrates/nitrites and activities of catalase, manganese and copper-zinc-superoxide dismutase decreased vs intact Control, Castrated Metabolic Syndrome males, intact Metabolic Syndrome and Ovariectomized Metabolic Syndrome + Estradiol females. The results suggest that sex hormones modulate the activity of superoxide-dismutase, catalase and endothelial nitric oxide-synthase. Ovariectomy decreased the protection against oxidative stress in females; the opposite occurred in castrated males.
C1 [El Hafidi, Mohammed; Banos, Guadalupe] Inst Nacl Cardiol Ignacio Chavez, Dept Biochem, Secc 16, Mexico City 14080, DF, Mexico.
   [Perez-Torres, Israel; Roque, Priscilla] Inst Nacl Cardiol Ignacio Chavez, Dept Pathol, Secc 16, Mexico City 14080, DF, Mexico.
   [Diaz-Diaz, Eulises] Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Reprod Biol, Secc 16, Mexico City 14000, DF, Mexico.
C3 National Institute of Cardiology - Mexico; National Institute of
   Cardiology - Mexico; Instituto Nacional de Ciencias Medicas y Nutricion
   Salvador Zubiran - Mexico
RP Baños, G (corresponding author), Inst Nacl Cardiol Ignacio Chavez, Dept Biochem, Secc 16, Juan Badiano 1, Mexico City 14080, DF, Mexico.
EM gbanos@yahoo.com
RI El-Hafidi, Mohammed/AAN-4083-2021; Pérez Torres, Israel/AAE-2579-2022
OI Perez-Torres, Israel/0000-0001-6510-2954
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NR 54
TC 58
Z9 59
U1 0
U2 6
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1071-5762
EI 1029-2470
J9 FREE RADICAL RES
JI Free Radic. Res.
PY 2009
VL 43
IS 8
BP 761
EP 771
AR PII 913046340
DI 10.1080/10715760903045296
PG 11
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 468QN
UT WOS:000267835000008
PM 19526391
DA 2025-06-11
ER

PT J
AU Rossetto, A
   De Re, V
   Steffan, A
   Ravaioli, M
   Miolo, G
   Leone, P
   Racanelli, V
   Uzzau, A
   Baccarani, U
   Cescon, M
AF Rossetto, Anna
   De Re, Valli
   Steffan, Agostino
   Ravaioli, Matteo
   Miolo, Gianmaria
   Leone, Patrizia
   Racanelli, Vito
   Uzzau, Alessandro
   Baccarani, Umberto
   Cescon, Matteo
TI Carcinogenesis and Metastasis in Liver: Cell Physiological Basis
SO CANCERS
LA English
DT Review
DE hepatocellular carcinoma; nonalcoholic fatty liver disease; nonalcoholic
   steatohepatitis; hepatic stellate cells; myofibroblasts; VEGF; immunity;
   circadian homeostasis; cortisol
ID HEPATOCELLULAR-CARCINOMA; GUT MICROBIOTA; HEPATIC INFLAMMATION;
   NONCIRRHOTIC LIVER; COLORECTAL-CANCER; MECHANISMS; FIBROSIS; STRESS;
   HOMEOSTASIS; NEUTROPHILS
AB Hepatocellular carcinoma (HCC) incidence is rising. This paper summarises the current state of knowledge and recent discoveries in the cellular and physiological mechanisms leading to the development of liver cancer, especially HCC, and liver metastases. After reviewing normal hepatic cytoarchitecture and immunological characteristics, the paper addresses the pathophysiological factors that cause liver damage and predispose to neoplasia. Particular attention is given to chronic liver diseases, metabolic syndrome and the impact of altered gut microbiota, disrupted circadian rhythm and psychological stress. Improved knowledge of the multifactorial aetiology of HCC has important implications for the prevention and treatment of this cancer and of liver metastases in general.
C1 [Rossetto, Anna; Ravaioli, Matteo; Cescon, Matteo] Univ Hosp Bologna, Dept Organ Insufficiency & Transplantat Gen Surg, Policlin S Orsola Malpighi, I-40138 Bologna, Italy.
   [De Re, Valli; Steffan, Agostino] IRCCS, Ctr Riferimento Oncol Aviano CRO, Immunopatol & Biomarcatori Oncol Bioprote Facil, I-33081 Aviano, Italy.
   [Miolo, Gianmaria] IRCCS, Dept Med Oncol, Ctr Riferimento Oncol Aviano CRO, I-33081 Aviano, Italy.
   [Leone, Patrizia; Racanelli, Vito] Univ Bari Med Sch, Dept Biomed Sci & Human Oncol, G Baccelli Sect Internal Med, I-70124 Bari, Italy.
   [Uzzau, Alessandro] Univ Udine, Dipartimento Area Med, Program Oncol Surg, I-33100 Udine, Italy.
   [Baccarani, Umberto] Univ Udine, Dipartimento Area Med, Surg & Transplantat, I-33100 Udine, Italy.
C3 IRCCS Azienda Ospedaliero-Universitaria di Bologna; IRCCS Aviano (CRO);
   IRCCS Aviano (CRO); Universita degli Studi di Bari Aldo Moro; University
   of Udine; University of Udine
RP Rossetto, A (corresponding author), Univ Hosp Bologna, Dept Organ Insufficiency & Transplantat Gen Surg, Policlin S Orsola Malpighi, I-40138 Bologna, Italy.; De Re, V (corresponding author), IRCCS, Ctr Riferimento Oncol Aviano CRO, Immunopatol & Biomarcatori Oncol Bioprote Facil, I-33081 Aviano, Italy.
EM anna.rossetto@aosp.bo.it; vdere@cro.it; asteffan@cro.it;
   matteo.ravaioli@aosp.bo.it; gmiolo@cro.it; patrizia.leone@uniba.it;
   vito.racanelli1@uniba.it; alessandro.uzzau@uniud.it;
   umberto.baccarani@uniud.it; matteo.cescon@aosp.bo.it
RI De Re, Valli/K-4121-2016; Leone, Patrizia/ABS-5217-2022; Ravaioli,
   Matteo/D-6314-2016; Rossetto, Anna/HIK-1742-2022; DE RE,
   VALLI/AAA-1374-2019; Miolo, Gianmaria/AAC-2351-2020; RACANELLI,
   Vito/J-8511-2018; Steffan, Agostino/ABE-5972-2020
OI Uzzau, Alessandro/0000-0001-6375-9995; DE RE, VALLI/0000-0001-6100-9373;
   Miolo, Gianmaria/0000-0001-5084-295X; RACANELLI,
   Vito/0000-0002-8639-1940; Steffan, Agostino/0000-0002-6320-3054; Cescon,
   Matteo/0000-0003-1715-3794; Ravaioli, Matteo/0000-0001-5862-6151
FU CRO, Italy [5X1000_2010_MdS]
FX This research work was supported by the CRO 5X1000_2010_MdS, Italy.
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NR 109
TC 26
Z9 29
U1 1
U2 24
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6694
J9 CANCERS
JI Cancers
PD NOV
PY 2019
VL 11
IS 11
AR 1731
DI 10.3390/cancers11111731
PG 16
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA JV3UB
UT WOS:000502290100113
PM 31694274
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Sideromenos, S
   Gundacker, A
   Nikou, M
   Oberle, R
   Horvath, O
   Stoehrmann, P
   Partonen, T
   Pollak, DD
AF Sideromenos, Spyridon
   Gundacker, Anna
   Nikou, Maria
   Oberle, Raimund
   Horvath, Orsolya
   Stoehrmann, Peter
   Partonen, Timo
   Pollak, Daniela D.
TI Uncoupling Protein-1 Modulates Anxiety-Like Behavior in a
   Temperature-Dependent Manner
SO JOURNAL OF NEUROSCIENCE
LA English
DT Article
DE anxiety; brown adipose tissue; fear; mouse behavior; uncoupling protein
   1
ID BROWN ADIPOSE-TISSUE; METABOLIC SYNDROME; FGF21; EXPRESSION; BRAIN;
   COLD; FAT; THERMOGENESIS; HOMEOSTASIS; OBESITY
AB A strong bidirectional link between metabolic and psychiatric disorders exists; yet, the molecular basis underlying this interaction remains unresolved. Here we explored the role of the brown adipose tissue (BAT) as modulatory interface, focusing on the involvement of uncoupling protein 1 (UCP-1), a key metabolic regulator highly expressed in BAT, in the control of emotional behavior. Male and female constitutive UCP-1 knock-out (KO) mice were used to investigate the consequences of UCP1 deficiency on anxiety-related and depression-related behaviors under mild thermogenic (23 degrees C) and thermoneutral (29 degrees C) conditions. UCP-1 KO mice displayed a selective enhancement of anxiety-related behavior exclusively under thermogenic conditions, but not at thermoneutrality. Neural and endocrine stress mediators were not affected in UCP-1 KO mice, which showed an activation of the integrated stress response alongside enhanced fibroblast-growth factor-21 (FGF-21) levels. However, viral-mediated overexpression of FGF-21 did not phenocopy the behavioral alterations of UCP-1 KO mice and blocking FGF-21 activity did not rescue the anxiogenic phenotype of UCP-1 KO mice. No effects of surgical removal of the intrascapular BAT on anxiety-like behavior or FGF-21 levels were observed in either UCP-1 KO or WT mice. We provide evidence for a novel role of UCP-1 in the regulation of emotions that manifests as inhibitory constraint on anxiety-related behavior, exclusively under thermogenic conditions. We propose this function of UCP-1 to be independent of its activity in the BAT and likely mediated through a central role of UCP-1 in brain regions with converging involvement in energy and emotional control.
C1 [Sideromenos, Spyridon; Gundacker, Anna; Nikou, Maria; Horvath, Orsolya; Stoehrmann, Peter; Pollak, Daniela D.] Med Univ Vienna, Ctr Physiol & Pharmacol, Dept Neurophysiol & Neuropharmacol, A-1090 Vienna, Austria.
   [Oberle, Raimund] Med Univ Vienna, Inst Med Chem & Pathobiochem, Ctr Pathobiochem & Genet, A-1090 Vienna, Austria.
   [Partonen, Timo] Finnish Inst Hlth & Welf, Mental Hlth Unit, FI-00271 Helsinki, Finland.
C3 Medical University of Vienna; Medical University of Vienna
RP Pollak, DD (corresponding author), Med Univ Vienna, Ctr Physiol & Pharmacol, Dept Neurophysiol & Neuropharmacol, A-1090 Vienna, Austria.
EM daniela.pollak@meduniwien.ac.at
RI Partonen, Timo/G-1105-2012
OI Sideromenos, Spyros/0000-0002-5135-3346; Gundacker,
   Anna/0000-0002-3645-881X; POLLAK, Daniela D./0000-0002-9584-6257;
   Oberle, Raimund/0000-0001-6701-4130; Stohrmann,
   Peter/0000-0002-7324-0414
FU Austrian Science Fund (Fonds fuer Wissenschaft und Forschung) [I 4854, P
   34281]
FX This work is supported by Austrian Science Fund (Fonds fuer Wissenschaft
   und Forschung) Grants I 4854 and P 34281 (to D.D.P.). We thank Maureen
   Cabatic and Christian Schubert for technical support
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NR 77
TC 4
Z9 5
U1 1
U2 12
PU SOC NEUROSCIENCE
PI WASHINGTON
PA 11 DUPONT CIRCLE, NW, STE 500, WASHINGTON, DC 20036 USA
SN 0270-6474
EI 1529-2401
J9 J NEUROSCI
JI J. Neurosci.
PD OCT 5
PY 2022
VL 42
IS 40
BP 7659
EP 7672
DI 10.1523/JNEUROSCI.2509-21.2022
PG 14
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 5M4ZT
UT WOS:000871105900010
PM 36194650
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Madaria, L
   Aymerich, C
   Catalan, A
   Gonzalez-Torres, MA
AF Madaria, Lander
   Aymerich, Claudia
   Catalan, Ana
   Gonzalez-Torres, Miguel Angel
TI Protocol of an Efficacy Study on Nursing Consultation in Weight
   Management and Metabolic Syndrome Based on the Carbohydrate-Insulin
   Theory in Individuals with First-Episode Psychosis
SO NURSING REPORTS
LA English
DT Article
DE nursing; mental health; metabolic syndrome; insulin resistance;
   psychosis
ID BIPOLAR DISORDER; SCHIZOPHRENIA; PREVALENCE; HEALTH; MORTALITY; PEOPLE;
   SCALE; DIET; INTERVENTIONS; METAANALYSIS
AB Background: Individuals with severe mental illness live, on average, up to 30 years less than the general population, with cardiovascular disease being the leading cause of death. Metabolic syndrome (MetS) plays a significant role in this, making it crucial to manage this issue in individuals with psychosis at the onset of the illness. The approach to managing this issue has evolved from a focus on calorie counting to a deeper understanding of hormone function, particularly the role of insulin resistance in MetS. Therefore, incorporating this perspective into mental health nursing consultations with individuals experiencing psychosis is of great interest. Methods: In accordance with the SPIRIT guidelines, an open randomized clinical trial is proposed, involving patients from a first-episode psychosis program. Results: The primary outcome will be significant weight loss (>= 5%). Secondary outcomes will include changes in metabolic parameters, psychopathological status, quality of life, and physical activity. Participants will be assigned to two groups: one group will attend a series of six previously manualized nursing consultations, while the other will continue with their usual treatment. Results will be evaluated at six months and one year. Conclusions: This study will determine whether a mental health nursing consultation based on the carbohydrate-insulin model of obesity is effective in reducing weight and the risk of MetS in individuals with early-onset psychosis. This study was retrospectively registered on Clinical Trials-NCT06650943.
C1 [Madaria, Lander; Aymerich, Claudia; Catalan, Ana; Gonzalez-Torres, Miguel Angel] Basurto Univ Hosp, Psychiat Dept, Bilbao 48013, Spain.
   [Madaria, Lander; Aymerich, Claudia; Catalan, Ana; Gonzalez-Torres, Miguel Angel] Biocruces Bizkaia Hlth Res Inst, Bizkaia 48903, Spain.
   [Madaria, Lander; Aymerich, Claudia; Catalan, Ana; Gonzalez-Torres, Miguel Angel] Univ Basque Country, Neurosci Dept, UPV, EHU, Leioa 48940, Spain.
   [Aymerich, Claudia; Catalan, Ana; Gonzalez-Torres, Miguel Angel] Ctr Invest Red Salud Mental CIBERSAM, Madrid 28029, Spain.
   [Catalan, Ana] Kings Coll London, Dept Psychosis Studies, Inst Psychiat Psychol & Neurosci, London SE5 8AB, England.
C3 Basurto Hospital; University of Basque Country; CIBER - Centro de
   Investigacion Biomedica en Red; CIBERSAM; University of London; King's
   College London
RP Madaria, L (corresponding author), Basurto Univ Hosp, Psychiat Dept, Bilbao 48013, Spain.; Madaria, L (corresponding author), Biocruces Bizkaia Hlth Res Inst, Bizkaia 48903, Spain.; Madaria, L (corresponding author), Univ Basque Country, Neurosci Dept, UPV, EHU, Leioa 48940, Spain.
EM lander.madariamarijuan@osakidetza.eus;
   claudia.aymerichnicolas@osakidetza.eus;
   ana.catalanalcantara@osakidetza.eus;
   miguelangel.gonzaleztorres@osakidetza.eus
RI Catalan, Ana/AAL-2224-2020
OI Madaria, Lander/0009-0002-5277-1790; Catalan, Ana/0000-0002-0418-7904;
   Gonzalez-Torres, Miguel Angel/0000-0002-4017-2785
FU Biobizkaia Research Institute
FX This article has been funded for open access by Biobizkaia Research
   Institute.
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NR 43
TC 0
Z9 0
U1 3
U2 3
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 2039-439X
EI 2039-4403
J9 NURS REP
JI Nurs. Rep.
PD JAN
PY 2025
VL 15
IS 1
AR 3
DI 10.3390/nursrep15010003
PG 10
WC Nursing
WE Emerging Sources Citation Index (ESCI)
SC Nursing
GA T3O6L
UT WOS:001404146400001
PM 39852625
OA gold
DA 2025-06-11
ER

PT J
AU Severi, E
   Ferrara, M
   Tedeschini, E
   Vacca, F
   Mungai, F
   Amendolara, R
   Baccari, F
   Starace, F
AF Severi, Elena
   Ferrara, Maria
   Tedeschini, Enrico
   Vacca, Francesca
   Mungai, Francesco
   Amendolara, Rocco
   Baccari, Flavia
   Starace, Fabrizio
TI Assessment of cardiovascular risk in an Italian psychiatric outpatient
   sample: A chart review of patients treated with second-generation
   antipsychotics
SO INTERNATIONAL JOURNAL OF MENTAL HEALTH NURSING
LA English
DT Review
DE antipsychotics; cardiovascular risk; metabolic syndrome; physical health
ID PHYSICAL HEALTH-CARE; METABOLIC SYNDROME; MENTAL-ILLNESS; CONSENSUS
   STATEMENT; EXCESS MORTALITY; SCHIZOPHRENIA; INTERVENTION; DISORDERS;
   PREVALENCE; PSYCHOSIS
AB Despite the call by the scientific community for a systematic monitoring of physical health in people with psychiatric illnesses, national and international audits have reported poor quality of cardiovascular risk assessments and management in this vulnerable population. Available evidence indicates that in people affected by mental illness, life expectancy is reduced by 10-20 years, mainly due to cardiovascular accidents and metabolic syndrome (MetS)-related diseases. The primary aim of the present study was to evaluate the accuracy of cardiovascular risk monitoring in an outpatient sample of patients taking second-generation antipsychotics. The sample consisted of 200 patients consecutively recruited from two community mental health centres. A clinical chart review was performed on the following laboratory tests: total cholesterol, high- and low-density lipoprotein, serum triglycerides, fasting blood glucose, -glutamyl transpeptidase. Blood pressure and waist circumference were measured. A complete cardiovascular risk assessment was available only in 60 patients out of 200 (33.3%). The only variable associated with laboratory tests for MetS was receiving three or more psychotropic medications, which increased fourfold the probability of metabolic screening. In the subsample of patients with full screening, the prevalence of MetS was 33.3%. Our findings suggest that mental health professionals working in community mental health services should incorporate a more systematic assessment of physical health in their practice, and intervene proactively to reduce the significant cardiovascular burden carried by people with several mental illness.
C1 [Severi, Elena; Ferrara, Maria; Tedeschini, Enrico; Vacca, Francesca; Mungai, Francesco; Amendolara, Rocco; Baccari, Flavia; Starace, Fabrizio] Dept Mental Hlth & Drug Abuse, Azienda Unita Sanitaria Locale Modena, Modena, Italy.
RP Mungai, F (corresponding author), AUSL Modena, Dept Mental Hlth & Drug Abuse, Viale Muratori 201, I-41124 Modena, Italy.
EM f.mungai@ausl.mo.it
RI Ferrara, Maria/ABP-9324-2022; Amendolara, Rocco/AAA-4768-2021; Mungai,
   Francesco/JAX-3878-2023
OI Amendolara, Rocco/0000-0001-7739-0404; Ferrara,
   Maria/0000-0003-2143-1101
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NR 40
TC 6
Z9 6
U1 1
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1445-8330
EI 1447-0349
J9 INT J MENT HEALTH NU
JI Int. J. Ment. Health Nurs.
PD JUN
PY 2018
VL 27
IS 3
BP 1002
EP 1008
DI 10.1111/inm.12407
PG 7
WC Nursing; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Psychiatry
GA GF5IG
UT WOS:000431999300008
PM 29197134
DA 2025-06-11
ER

PT J
AU Zeng, CR
   Yang, P
   Cao, T
   Gu, YX
   Li, NN
   Zhang, BK
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   Liu, YP
   Luo, ZY
   Cai, HL
AF Zeng, CuiRong
   Yang, Ping
   Cao, Ting
   Gu, YuXiu
   Li, NaNa
   Zhang, BiKui
   Xu, Ping
   Liu, YiPing
   Luo, ZhiYing
   Cai, HuaLin
TI Gut microbiota: An intermediary between metabolic syndrome and cognitive
   deficits in schizophrenia
SO PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
LA English
DT Review
DE Gut microbiota; Metabolic syndrome; Weight gain; Cognitive deficits;
   Atypical antipsychotic drugs; Schizophrenia
ID C-REACTIVE PROTEIN; INDUCED WEIGHT-GAIN; BODY-MASS INDEX; NEUROTROPHIC
   FACTOR BDNF; CHAIN FATTY-ACIDS; ANXIETY-LIKE BEHAVIOR; DIET-INDUCED
   OBESITY; INSULIN-RESISTANCE; INDOLEAMINE 2,3-DIOXYGENASE; INFLAMMATORY
   CYTOKINES
AB Gut microbiome interacts with the central nervous system tract through the gut-brain axis. Such communication involves neuronal, endocrine, and immunological mechanisms, which allows for the microbiota to affect and respond to various behaviors and psychiatric conditions. In addition, the use of atypical antipsychotic drugs (AAPDs) may interact with and even change the abundance of microbiome to potentially cause adverse effects or aggravate the disorders inherent in the disease. The regulate effects of gut microbiome has been described in several psychiatric disorders including anxiety and depression, but only a few reports have discussed the role of microbiota in AAPDs-induced Metabolic syndrome (MetS) and cognitive disorders. The following review systematically summarizes current knowledge about the gut microbiota in behavior and psychiatric illness, with the emphasis of an important role of the microbiome in the metabolism of schizophrenia and the potential for AAPDs to change the gut microbiota to promote adverse events. Prebiotics and probiotics are microbiota-management tools with documented efficacy for metabolic disturbances and cognitive deficits. Novel therapies for targeting microbiota for alleviating AAPDs-induced adverse effects are also under fast development.
C1 [Zeng, CuiRong; Cao, Ting; Gu, YuXiu; Li, NaNa; Zhang, BiKui; Xu, Ping; Liu, YiPing; Luo, ZhiYing; Cai, HuaLin] Cent South Univ, Dept Pharm, Xiangya Hosp 2, Changsha 410011, Hunan, Peoples R China.
   [Zeng, CuiRong; Cao, Ting; Gu, YuXiu; Li, NaNa; Zhang, BiKui; Xu, Ping; Liu, YiPing; Luo, ZhiYing; Cai, HuaLin] Cent South Univ, Inst Clin Pharm, Changsha 410011, Hunan, Peoples R China.
   [Yang, Ping] Second Peoples Hosp Hunan Prov, Dept Psychiat, Changsha 410007, Hunan, Peoples R China.
C3 Central South University; Central South University
RP Cai, HL (corresponding author), Cent South Univ, Dept Pharm, Xiangya Hosp 2, Changsha 410011, Hunan, Peoples R China.; Cai, HL (corresponding author), Cent South Univ, Inst Clin Pharm, Changsha 410011, Hunan, Peoples R China.
EM hualincai@csu.edu.cn
RI Gu, Yuxiu/IST-5247-2023; li, nana/KHX-9502-2024
OI Yuxiu, Gu/0000-0001-9869-9830
FU Nature Science Foundation of China [NSFC81401113]; Hunan Provincial
   Natural Science Foundation of China [2017JJ3444]; Wu Jieping Medical
   Foundation Funded Special Clinical Research Project
   [320.6750.2020-04-2]; Fundamental Research Funds for the Central
   Universities of Central South University [2019zzts1049, 2020zzts884]
FX This study was supported in part by the grants from the Nature Science
   Foundation of China [NSFC81401113], Hunan Provincial Natural Science
   Foundation of China [2017JJ3444], Wu Jieping Medical Foundation Funded
   Special Clinical Research Project [320.6750.2020-04-2] and the
   Fundamental Research Funds for the Central Universities of Central South
   University [2019zzts1049, 2020zzts884].
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NR 217
TC 27
Z9 27
U1 4
U2 73
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0278-5846
EI 1878-4216
J9 PROG NEURO-PSYCHOPH
JI Prog. Neuro-Psychopharmacol. Biol. Psychiatry
PD MAR 2
PY 2021
VL 106
AR 110097
DI 10.1016/j.pnpbp.2020.110097
PG 14
WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA PH8ZU
UT WOS:000600694200018
PM 32916223
DA 2025-06-11
ER

PT J
AU Jiao, JT
   Wang, L
   Huang, J
   Cheng, C
   Huang, WY
   Yuan, KM
   Feng, SY
   Zhang, YS
   Zhang, N
   Di, PG
   Feng, S
   Shao, JF
   Wang, F
AF Jiao, Jiantong
   Wang, Long
   Huang, Jin
   Cheng, Chao
   Huang, Weiyi
   Yuan, Kemiao
   Feng, Suyin
   Zhang, Yansong
   Zhang, Na
   Di, Pinggang
   Feng, Shuo
   Shao, Junfei
   Wang, Fang
TI The effect of metabolic factors on the post-stroke depression of
   ischemic stroke patients
SO INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
LA English
DT Article
DE Post-stoke depression; metabolic syndrome factors; blood glucose;
   glycosylated hemoglobin
ID IMPAIRED GLUCOSE-METABOLISM; NATURAL-HISTORY; SERUM-LEVELS; SYMPTOMS;
   ASSOCIATION; BRAIN; METAANALYSIS; DISORDERS; ANXIETY; MOOD
AB Objective: To investigate the relationship between metabolic syndrome (MetS) risk factors and the risk of post-stroke depression (PSD) in ischemic stroke patients. Methods: A total of 667 ischemic stroke patients participated in blood sample collection for the analysis of MetS risk factors, and in the Diagnostic and Statistical Manual of Mental Disorders, 4th edition (DSM-IV) testing. The association between MetS risk factors and the risk of PSD was assessed using Cox regression proportional hazards models, and the Chi-squared test was used to evaluate differences in demographic variables and clinical characteristics in the subgroups. Results: In our study, the incidence of PSD in the 2-year follow-up was 35.4%. The risk of PSD was elevated with increased blood glucose levels (Hazard ratio [HR]: 2.147, 95% confidence interval [CI]: 1.331-3.463; top vs. bottom quartile) and glycosylated hemoglobin (HbA1c) (HR: 2.348, 95% CI: 1.424-3.871; top vs. bottom quartile). The hazard ratio was increased for z-scores of blood glucose and HbA1c, and for the combined metabolic syndrome score. In addition, the risk of PSD was increased in ischemic stroke patients with high blood glucose levels (>= 6.0mmol/l) and with HbA1c (>= 6.5%). However, we did not find significant associations between PSD and other MetS risk factors, including body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP), cholesterol, and triglycerides. Conclusions: Depression is prevalent among ischemic stroke patients. Blood glucose levels and HbA1c are positively associated with the risk of PSD and might be useful bio-markers to predict its development.
C1 [Jiao, Jiantong; Huang, Jin; Cheng, Chao; Huang, Weiyi; Shao, Junfei] Wuxi Peoples Hosp, Dept Neurosurg, Wuxi, Jiangsu, Peoples R China.
   [Wang, Fang] Heping Hosp, Changzhi Med Coll, Dept Endocrinol & Metab, Changzhi, Shanxi, Peoples R China.
   [Wang, Long] Heping Hosp, Changzhi Med Coll, Dept Neurosurg, Changzhi, Shanxi, Peoples R China.
   [Yuan, Kemiao] Tradit Chinese Med Hosp Wuxi, Dept Oncol, Wuxi, Jiangsu, Peoples R China.
   [Feng, Suyin] Fourth Peoples Hosp Wuxi, Dept Neurosurg, Wuxi, Jiangsu, Peoples R China.
   [Zhang, Yansong] Nanjing Med Univ, Nanjing Brain Hosp, Dept Neurosurg, Nanjing, Jiangsu, Peoples R China.
   [Zhang, Na] Nanchang Univ, Hosp 1, Dept Neurol, Nanchang, Jiangxi, Peoples R China.
   [Di, Pinggang] Wulian Peoples Hosp, Dept Neurol, Wulian, Shandong, Peoples R China.
   [Feng, Shuo] Jiaonan Peoples Hosp, Dept Neurosurg, Qingdao, Shandong, Peoples R China.
C3 Jiangnan University; Changzhi Medical College; Changzhi Medical College;
   Jiangnan University; Nanjing Medical University; Nanchang University
RP Shao, JF (corresponding author), Nanjing Med Univ, Wuxi Peoples Hosp, Dept Neurosurg, Qiangyang Rd 299, Wuxi, Jiangsu, Peoples R China.; Wang, F (corresponding author), Heping Hosp, Changzhi Med Coll, Endocrinol & Metab, Yanan South Rd 110, Changzhi, Shanxi, Peoples R China.
EM wxhneurosurgery@126.com; wangfangczmu@126.com
RI Feng, Shuo/LUY-7211-2024; Huang, Weiyi/HDO-2270-2022; cheng,
   chao/HCI-6356-2022
OI cheng, chao/0000-0002-9380-3296
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NR 47
TC 1
Z9 1
U1 0
U2 8
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 1940-5901
J9 INT J CLIN EXP MED
JI Int. J. Clin. Exp. Med.
PY 2019
VL 12
IS 4
BP 4174
EP 4183
PG 10
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Research & Experimental Medicine
GA HW2DW
UT WOS:000466494200124
DA 2025-06-11
ER

PT J
AU Lalanza, JF
   Caimari, A
   del Bas, JM
   Torregrosa, D
   Cigarroa, I
   Pallàs, M
   Capdevila, L
   Arola, L
   Escorihuela, RM
AF Lalanza, Jaume F.
   Caimari, Antoni
   del Bas, Josep M.
   Torregrosa, Daniel
   Cigarroa, Igor
   Pallas, Merce
   Capdevila, Lluis
   Arola, Lluis
   Escorihuela, Rosa M.
TI Effects of a Post-Weaning Cafeteria Diet in Young Rats: Metabolic
   Syndrome, Reduced Activity and Low Anxiety-Like Behaviour
SO PLOS ONE
LA English
DT Article
ID ELEVATED PLUS-MAZE; HIGH-FAT DIET; PALATABLE DIET; ENVIRONMENTAL
   ENRICHMENT; SOCIAL-INTERACTION; CHRONIC STRESS; OBESITY; CONSUMPTION;
   OVERWEIGHT; EXPRESSION
AB Among adolescents, overweight, obesity and metabolic syndrome are rapidly increasing in recent years as a consequence of unhealthy palatable diets. Animal models of diet-induced obesity have been developed, but little is known about the behavioural patterns produced by the consumption of such diets. The aim of the present study was to determine the behavioural and biochemical effects of a cafeteria diet fed to juvenile male and female rats, as well as to evaluate the possible recovery from these effects by administering standard feeding during the last week of the study. Two groups of male and female rats were fed with either a standard chow diet (ST) or a cafeteria (CAF) diet from weaning and for 8 weeks. A third group of males (CAF withdrawal) was fed with the CAF diet for 7 weeks and the ST in the 8th week. Both males and females developed metabolic syndrome as a consequence of the CAF feeding, showing overweight, higher adiposity and liver weight, increased plasma levels of glucose, insulin and triglycerides, as well as insulin resistance, in comparison with their respective controls. The CAF diet reduced motor activity in all behavioural tests, enhanced exploration, reduced anxiety-like behaviour and increased social interaction; this last effect was more pronounced in females than in males. When compared to animals only fed with a CAF diet, CAF withdrawal increased anxiety in the open field, slightly decreased body weight, and completely recovered the liver weight, insulin sensitivity and the standard levels of glucose, insulin and triglycerides in plasma. In conclusion, a CAF diet fed to young animals for 8 weeks induced obesity and metabolic syndrome, and produced robust behavioural changes in young adult rats, whereas CAF withdrawal in the last week modestly increased anxiety, reversed the metabolic alterations and partially reduced overweight.
C1 [Lalanza, Jaume F.; Torregrosa, Daniel; Cigarroa, Igor; Escorihuela, Rosa M.] Univ Autonoma Barcelona, Inst Neurociencies, Dept Psiquiatria & Med Legal, E-08193 Barcelona, Spain.
   [Lalanza, Jaume F.; Capdevila, Lluis] Univ Autonoma Barcelona, Dept Psicol Basica, Lab Psicol Esport, E-08193 Barcelona, Spain.
   [Caimari, Antoni; del Bas, Josep M.; Arola, Lluis] CEICS, TECNIO, CTNS, Reus, Spain.
   [Cigarroa, Igor] Univ Santo Tomas, Fac Salud, Santiago, Chile.
   [Pallas, Merce] Univ Barcelona, Fac Farm, Inst Biomed, Seccio Farmacol & Farmacognosia, E-08028 Barcelona, Spain.
   [Pallas, Merce] Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain.
   [Arola, Lluis] Univ Rovira & Virgili, Nutrigen Res Grp, Dept Bioquim & Biotecnol, E-43007 Tarragona, Spain.
C3 Autonomous University of Barcelona; Autonomous University of Barcelona;
   Universidad Santo Tomas; University of Barcelona; CIBERNED; Universitat
   Rovira i Virgili
RP Escorihuela, RM (corresponding author), Univ Autonoma Barcelona, Inst Neurociencies, Dept Psiquiatria & Med Legal, E-08193 Barcelona, Spain.
EM rosamaria.escorihuela@uab.cat
RI del Bas, Josep/K-9310-2019; cigarroa, igor/AAV-3527-2020; Pallas,
   Merce/H-3129-2016; Lalanza, Jaume F./C-9186-2011; Escorihuela, Rosa
   M/L-4524-2014; Capdevila, Lluis/I-2530-2015; Arola, Lluis/C-6074-2011
OI Pallas, Merce/0000-0003-3095-4254; Lalanza, Jaume
   F./0000-0003-2481-2188; Escorihuela, Rosa M/0000-0001-9368-5173;
   Capdevila, Lluis/0000-0002-7319-4745; Arola, Lluis/0000-0003-2767-1974;
   Caimari, Antoni/0000-0001-6144-0294; del Bas, Josep
   Maria/0000-0002-0700-2004
FU Spanish Ministry of Economy and Competitiveness [PSI
   2011-29807-C02/PSIC]; ACC1O [TECRD11-1-0012]; European Union [244995];
   Generalitat de Catalunya [FI-DGR 2011]; Universidad Santo Tomas de Chile
FX The research leading to these results has received funding from the
   Spanish Ministry of Economy and Competitiveness (PSI
   2011-29807-C02/PSIC), ACC1O (TECRD11-1-0012) and the European Union's
   Seventh Framework Programme FP7 2007-2013 under grant agreement nu
   244995 (BIOCLAIMS Project). JFL received a fellowship from the
   Generalitat de Catalunya (FI-DGR 2011) and IC received a fellowship from
   the Universidad Santo Tomas de Chile. The funders had no role in study
   design, data collection and analysis, decision to publish, or
   preparation of the manuscript.
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NR 55
TC 77
Z9 81
U1 0
U2 24
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JAN 15
PY 2014
VL 9
IS 1
AR e85049
DI 10.1371/journal.pone.0085049
PG 9
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 297DH
UT WOS:000330235100052
PM 24482678
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Norman, D
   Bardwell, WA
   Arosemena, F
   Nelesen, R
   Mills, PJ
   Loredo, JS
   Lavine, JE
   Dimsdale, JE
AF Norman, Daniel
   Bardwell, Wayne A.
   Arosemena, Farah
   Nelesen, Richard
   Mills, Paul J.
   Loredo, Jose S.
   Lavine, Joel E.
   Dimsdale, Joel E.
TI Serum aminotransferase levels are associated with markers of hypoxia in
   patients with obstructive sleep apnea
SO SLEEP
LA English
DT Article
DE transaminases; fatty liver; obstructive sleep apnea; hypoxia; metabolic
   syndrome X
ID NONALCOHOLIC FATTY LIVER; INTERMITTENT HYPOXIA; METABOLIC SYNDROME;
   OXIDATIVE STRESS; OBESE-PATIENTS; STEATOHEPATITIS; DISEASE; DIAGNOSIS;
   MICE
AB Study Objectives: Nonalcoholic fatty liver disease (NAFLD) is a disorder that often presents with elevated serum aminotransferase levels. Although it has classically been linked with the metabolic syndrome, recent studies suggest NAFLD may also be associated with obstructive sleep apnea (OSA). This study evaluates the association between serum aminotransferase levels and factors connected with: either the metabolic syndrome (elevated body mass index [BMI], lipid profile, blood pressure, fasting glucose), or with OSA severity (apnea hypopnea index, lowest oxygen saturation level, oxygen desaturation index, percent of time below 90% saturation [%T<90]).
   Design: Retrospective case series.
   Patients and Setting: 109 adult patients with OSA at a university hospital general clinical research center.
   Measurements and Results: Markers of hypoxia (lowest oxygen saturation level and %T<90), correlated significantly with aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels (Pearson's r = -0.31 to -0.38, P <0.003), while apnea hypopnea index, body mass index, blood pressure, fasting glucose, triglyceride, and cholesterol levels did not. Hierarchical linear regression was then done to determine the best predictors of aminotransferase levels. Markers of metabolic syndrome were entered as one block and markers of sleep apnea as another. Regression analyses explained 16.3% of the variance in AST and 18.9% of the variance in ALT, with %T<90 playing the largest role.
   Conclusions: In patients with obstructive sleep apnea, serum aminotransferase levels are better predicted by markers of oxygen desaturation than by factors traditionally associated with the metabolic syndrome.
C1 [Norman, Daniel; Loredo, Jose S.] Univ Calif San Diego, Dept Pulm & Crit Care Med, San Diego, CA 92103 USA.
   [Bardwell, Wayne A.; Arosemena, Farah; Nelesen, Richard; Mills, Paul J.; Dimsdale, Joel E.] Univ Calif San Diego, Dept Psychiat, San Diego, CA 92103 USA.
   [Lavine, Joel E.] Univ Calif San Diego, Dept Pediat Gastroenterol, San Diego, CA 92103 USA.
C3 University of California System; University of California San Diego;
   University of California System; University of California San Diego;
   University of California System; University of California San Diego
RP Norman, D (corresponding author), Univ Calif San Diego, Dept Pulm & Crit Care Med, 200 W Arbor Dr 8383, San Diego, CA 92103 USA.
EM d1norman@ucsd.edu
FU NCRR NIH HHS [M01 RR000827, RR00827] Funding Source: Medline; NHLBI NIH
   HHS [R01 HL044915, K23 HL04056, K23 HL004056, HL44915] Funding Source:
   Medline
CR Alberti KGMM, 1998, DIABETIC MED, V15, P539, DOI 10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S
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NR 26
TC 71
Z9 77
U1 0
U2 5
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
EI 1550-9109
J9 SLEEP
JI Sleep
PD JAN 1
PY 2008
VL 31
IS 1
BP 121
EP 126
DI 10.1093/sleep/31.1.121
PG 6
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 249XN
UT WOS:000252264000015
PM 18220085
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Groth, SW
   Fernandez, ID
   Block, RC
   Thurston, SW
   Wong, EY
   Brunner, J
   Mayo, N
   Kapula, N
   Yu, Y
   Meng, Y
   Yeh, KL
   Kinkade, CW
   Thornburg, LL
   O'Connor, TG
   Barrett, ES
AF Groth, Susan W.
   Fernandez, I. Diana
   Block, Robert C.
   Thurston, Sally W.
   Wong, Eunyoung
   Brunner, Jessica
   Mayo, Nicole
   Kapula, Ntemena
   Yu, Yang
   Meng, Ying
   Yeh, Kuan-Lin
   Kinkade, Carolyn W.
   Thornburg, Loralei L.
   O'Connor, Thomas G.
   Barrett, Emily S.
TI Biological changes in the pregnancy-postpartum period and subsequent
   cardiometabolic risk-UPSIDE MOMS: A research protocol
SO RESEARCH IN NURSING & HEALTH
LA English
DT Article
DE biological profile; cardiometabolic risk; childbearing women; maternal
   weight; pregnancy adaptation; postpartum
ID GESTATIONAL WEIGHT-GAIN; BODY-MASS INDEX; CARDIOVASCULAR RISK;
   PHYSICAL-ACTIVITY; INFLAMMATORY MARKERS; GLUCOSE-LEVELS; UNITED-STATES;
   OBESITY; HEALTH; WOMEN
AB Multiple physiological changes occur in pregnancy as a woman's body adapts to support the growing fetus. These pregnancy-induced changes are essential for fetal growth, but the extent to which they reverse after pregnancy remains in question. For some women, physiological changes persist after pregnancy and may increase long-term cardiometabolic disease risk. The National Institutes of Health-funded study described in this protocol addresses a scientific gap by characterizing weight and biological changes during pregnancy and an extended postpartum period in relation to cardiometabolic risk. We use a longitudinal repeated measures design to prospectively examine maternal health from early pregnancy until 3 years postpartum. The aims are: (1) identify maternal weight profiles in the pregnancy-postpartum period that predict adverse cardiometabolic risk profiles three years postpartum; (2) describe immune, endocrine, and metabolic biomarker profiles in the pregnancy-postpartum period, and determine their associations with cardiometabolic risk; and (3) determine how modifiable postpartum health behaviors (diet, physical activity, breastfeeding, sleep, stress) (a) predict weight and cardiometabolic risk in the postpartum period; and (b) moderate associations between postpartum weight retention and downstream cardiometabolic risk. The proposed sample is 250 women. This study of mothers is conducted in conjunction with the Understanding Pregnancy Signals and Infant Development study, which examines child health outcomes. Biological and behavioral data are collected in each trimester and at 6, 12, 24, and 36 months postpartum. Findings will inform targeted health strategies that promote health and reduce cardiometabolic risk in childbearing women.
C1 [Groth, Susan W.; Wong, Eunyoung; Yu, Yang; Meng, Ying; Yeh, Kuan-Lin] Univ Rochester, Sch Nursing, 601 Elmwood Ave,Box SON, Rochester, NY 14642 USA.
   [Fernandez, I. Diana; Mayo, Nicole] Univ Rochester, Sch Med & Dent, Dept Publ Hlth Sci, Rochester, NY USA.
   [Block, Robert C.] Univ Rochester, Dept Publ Hlth Sci, Rochester, NY USA.
   [Block, Robert C.] Univ Rochester, Dept Cardiol, Rochester, NY USA.
   [Block, Robert C.] Univ Rochester, Dept Med, Rochester, NY USA.
   [Thurston, Sally W.] Univ Rochester, Dept Biostat & Computat Biol, Rochester, NY USA.
   [Brunner, Jessica; Kapula, Ntemena; Thornburg, Loralei L.; Barrett, Emily S.] Univ Rochester, Med Ctr, Dept Obstet & Gynecol, Rochester, NY 14642 USA.
   [Kinkade, Carolyn W.; Barrett, Emily S.] Rutgers State Univ, Exposure Sci & Epidemiol, Environm & Occupat Hlth Sci Inst, New Brunswick, NJ USA.
   [O'Connor, Thomas G.] Univ Rochester, Dept Psychiat, Rochester, NY USA.
   [O'Connor, Thomas G.] Univ Rochester, Dept Psychol, Meliora Hall, Rochester, NY 14627 USA.
   [O'Connor, Thomas G.] Univ Rochester, Dept Neurosci, Rochester, NY USA.
   [O'Connor, Thomas G.] Univ Rochester, Dept Obstet & Gynecol, Rochester, NY USA.
   [O'Connor, Thomas G.] Univ Rochester, Wynne Ctr Family Res, Rochester, NY USA.
   [Barrett, Emily S.] Rutgers Sch Publ Hlth, Dept Biostat & Epidemiol, Piscataway, NJ USA.
C3 University of Rochester; University of Rochester; University of
   Rochester; University of Rochester; University of Rochester; University
   of Rochester; University of Rochester; Rutgers University System;
   Rutgers University New Brunswick; University of Rochester; University of
   Rochester; University of Rochester; University of Rochester; University
   of Rochester; Rutgers University System
RP Groth, SW (corresponding author), Univ Rochester, Sch Nursing, 601 Elmwood Ave,Box SON, Rochester, NY 14642 USA.
EM Susan_groth@urmc.rochester.edu
OI Brunner, Jessica/0009-0003-3882-1138; Groth, Susan
   W/0000-0002-3672-7696; Kinkade, Carolyn/0000-0002-8549-5553; Yu,
   Yang/0000-0003-3635-1139; Kapula, Ntemena/0000-0002-4159-8913; Thurston,
   Sally/0000-0003-2538-762X
FU National Institutes of Nursing Research [R01NR017602]; Child Health and
   Development [R01HD083369]; Environmental Health Sciences [P30ES005022,
   P30ES001247]; Office of the Director [UH3OD023349, UG3 OD023349]; Center
   for Environmental Exposure and Disease (NIEHS, Rutgers); Environmental
   Health Sciences Center (NIEHS; Rochester); Richard W and Mae Stone Goode
   Foundation; University of Rochester, School of Nursing; Wynne Center for
   Family Research
FX National Institutes of Nursing Research (R01NR017602), Child Health and
   Development (R01HD083369), Environmental Health Sciences (P30ES005022;
   P30ES001247), Office of the Director (UH3OD023349; UG3 OD023349); Center
   for Environmental Exposure and Disease (NIEHS, Rutgers); Environmental
   Health Sciences Center (NIEHS; Rochester); Richard W and Mae Stone Goode
   Foundation; University of Rochester, School of Nursing; Wynne Center for
   Family Research.
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NR 84
TC 7
Z9 7
U1 0
U2 10
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0160-6891
EI 1098-240X
J9 RES NURS HEALTH
JI Res. Nurs. Health
PD AUG
PY 2021
VL 44
IS 4
BP 608
EP 619
DI 10.1002/nur.22141
EA MAY 2021
PG 12
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA TE4DQ
UT WOS:000650935400001
PM 33993510
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Nozu, T
   Okumura, T
AF Nozu, Tsukasa
   Okumura, Toshikatsu
TI Pathophysiological Commonality Between Irritable Bowel Syndrome and
   Metabolic Syndrome: Role of Corticotropin-releasing Factor-Toll-like
   Receptor 4-Proinflammatory Cytokine Signaling
SO JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY
LA English
DT Review
DE Gut barrier; Irritable bowel syndrome; Metabolic syndrome; Microbiota;
   Toll-like receptor 4
ID COLONIC EPITHELIAL BARRIER; STRESS-RELATED ALTERATIONS; WATER AVOIDANCE
   STRESS; GUT MICROBIOTA; VISCERAL HYPERSENSITIVITY; FATTY-ACIDS; RECTAL
   HYPERSENSITIVITY; INTESTINAL MICROBIOTA; MATERNAL-DEPRIVATION;
   PSYCHOLOGICAL STRESS
AB Irritable bowel syndrome (IBS) displays chronic abdominal pain with altered defecation. Most of the patients develop visceral hypersensitivity possibly resulting from impaired gut barrier and altered gut microbiota. We previously demonstrated that colonic hyperpermeability with visceral hypersensitivity in animal IBS models, which is mediated via corticotropin-releasing factor (CRF)-Tolllike receptor 4 (TLR4)-proinflammatory cytokine signaling. CRF impairs gut barrier via TLR4. Leaky gut induces bacterial translocation resulting in dysbiosis, and increases lipopolysaccharide (LPS). Activation of TLR4 by LPS increases the production of proinflammatory cytokines, which activate visceral sensory neurons to induce visceral hypersensitivity. LPS also activates CRF receptors to further increase gut permeability. Metabolic syndrome (MS) is a cluster of cardiovascular risk factors, including insulin resistance, obesity, dyslipidemia, and hypertension, and recently several researchers suggested the possibility that impaired gut barrier and dysbiosis with low-grade systemic inflammation are involved in MS. Moreover, TLR4-proinflammatory cytokine contributes to the development of insulin resistance and obesity. Thus, the existence of pathophysiological commonality between IBS and MS is expected. This review discusses the potential mechanisms of IBS and MS with reference to gut barrier and microbiota, and explores the possibility of existence of a pathophysiological link between these diseases with a focus on CRF, TLR4, and proinflammatory cytokine signaling. We also review epidemiological data supporting this possibility, and discuss the potential of therapeutic application of the drugs used for MS to IBS treatment. This notion may pave the way for exploring novel therapeutic approaches for these disorders.
C1 [Nozu, Tsukasa] Asahikawa Med Univ, Dept Reg Med & Educ, 2-1-1-1 Midorigaoka Higashi, Asahikawa, Hokkaido 0788510, Japan.
   [Nozu, Tsukasa] Asahikawa Med Univ, Ctr Med Educ, Asahikawa, Hokkaido, Japan.
   [Okumura, Toshikatsu] Asahikawa Med Univ, Dept Med, Div Gastroenterol & Hematol Oncol, Asahikawa, Hokkaido, Japan.
   [Okumura, Toshikatsu] Asahikawa Med Univ, Dept Gen Med, Asahikawa, Hokkaido, Japan.
C3 Asahikawa Medical College; Asahikawa Medical College; Asahikawa Medical
   College; Asahikawa Medical College
RP Nozu, T (corresponding author), Asahikawa Med Univ, Dept Reg Med & Educ, 2-1-1-1 Midorigaoka Higashi, Asahikawa, Hokkaido 0788510, Japan.
EM tnozu@sea.plala.or.jp
FU Grants-in-Aid for Scientific Research [22K08790] Funding Source: KAKEN
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NR 127
TC 15
Z9 15
U1 2
U2 15
PU KOREAN SOC NEUROGASTROENTEROLOGY & MOTILITY
PI GANGNAM-GU
PA RM 305, LOTTE GOLD ROSE VILL II, 31 SEOLLEUNG-RO 86-GIL, GANGNAM-GU,
   SEOUL 135-839, SOUTH KOREA
SN 2093-0879
EI 2093-0887
J9 J NEUROGASTROENTEROL
JI J. Neurogastroenterol. Motil.
PD APR
PY 2022
VL 28
IS 2
BP 173
EP 184
DI 10.5056/jnm21002
PG 12
WC Gastroenterology & Hepatology; Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Neurosciences & Neurology
GA 0N4KW
UT WOS:000782809500004
PM 35189599
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Olofinnade, AT
   Alawode, A
   Onaolapo, AY
   Onaolapo, OJ
AF Olofinnade, Anthony T.
   Alawode, Abiola
   Onaolapo, Adejoke Y.
   Onaolapo, Olakunle J.
TI Lepidium meyenii Supplemented Diet Modulates Neurobehavioral and
   Bio-chemical Parameters in Mice Fed High-Fat High-Sugar Diet
SO ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS
LA English
DT Article
DE Diet; functional food; metabolic syndrome; neurobehavior; nutraceutical;
   neurodegeneration
ID OXIDATIVE STRESS; METABOLIC SYNDROME; MONOSODIUM GLUTAMATE; DAYTIME
   MELATONIN; OBESITY; MEMORY
AB Background Metabolic syndrome has been associated with an increased risk of cardiovascular disease, diabetes mellitus, and neurodegenerative disorders. Known side-effects of currently-available drugs necessitate the search for possibly better treatment options. Objective: This study examined the effects of dietary lepidium meyenii (MACA) supplementation on neurobehaviour, metabolic profile, levels of inflammatory markers, and oxidative stress parameters in a mouse model of metabolic syndrome. Methods: Mice were randomly assigned into 8 groups of ten animals each. Groups consist of standard diet (SD) control, high fat/high sugar (HFHS) control and three groups each of lepidium meyenii incorporated into either SD or HFHS diet at 0.1, 0.2 and 0.4%. Mice were fed for seven weeks, and body weight was measured weekly. Open-field behaviors and radial-arm/Y-maze spatial memory were scored at the end of the study. Twenty-four hours after the last behavioral test, fasting blood glucose levels were estimated. Animals were then euthanized, and blood was drawn for estimation of serum lipid profile. Whole brains were excised, weighed and homogenized to estimate the levels of lipid peroxidation, inflammatory markers, antioxidant status, and acetylcholinesterase activity. Results: MACA-supplemented diet was associated with a decrease in body weight gain, an increase in food intake (at lower concentrations), suppression of grooming behavior, and decrease in acetylcholinesterase activity. MACA-supplement also reversed HFHS-induced memory impairment, anxiety, hyperglycaemia, lipid derangement, oxidative stress, and derangement of inflammatory markers. Conclusion: Dietary supplementation with MACA shows beneficial effects in mitigating the effects of metabolic syndrome on the brain in mice.
C1 [Olofinnade, Anthony T.] Lagos State Univ, Coll Med, Fac Basic Clin Sci, Dept Pharmacol Therapeut & Toxicol, Ikeja, Lagos State, Nigeria.
   [Alawode, Abiola] Ladoke Akintola Univ Technol, Depat Anat, Ogbomosho, Oyo State, Nigeria.
   [Onaolapo, Adejoke Y.] Ladoke Akintola Univ Technol, Behav Neurosci Neurobiol Unit, Dept Anat, Ogbomosho, Oyo State, Nigeria.
   [Olofinnade, Anthony T.; Onaolapo, Olakunle J.] Ladoke Akintola Univ Technol, Behav Neurosci Neuropharmacol Unit, Dept Pharmacol, Osogbo, Osun State, Nigeria.
C3 Lagos State University
RP Onaolapo, AY (corresponding author), Ladoke Akintola Univ Technol, Behav Neurosci Neurobiol Unit, Dept Anat, Ogbomosho, Oyo State, Nigeria.
EM adegbayibiy@yahoo.com
RI Onaolapo, Adejoke/HRC-4273-2023
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NR 55
TC 9
Z9 9
U1 0
U2 10
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1871-5303
EI 2212-3873
J9 ENDOCR METAB IMMUNE
JI Endocr. Metab. Immune Disord.-Drug Targets
PY 2021
VL 21
IS 7
BP 1333
EP 1343
DI 10.2174/1871530320666200821155005
PG 11
WC Endocrinology & Metabolism; Immunology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Immunology; Pharmacology & Pharmacy
GA UE6BY
UT WOS:000687972400004
PM 32955007
DA 2025-06-11
ER

PT J
AU Lua, ACY
   How, CH
   King, TFJ
AF Lua, Angelyn Chen Yin
   How, Choon How
   King, Thomas F. J.
TI Managing polycystic ovary syndrome in primary care
SO SINGAPORE MEDICAL JOURNAL
LA English
DT Article
DE anovulation; hirsutism; hyperandrogenism; infertility; polycystic ovary
   syndrome
ID DIAGNOSIS; SOCIETY
AB Polycystic ovary syndrome (PCOS) presents with a spectrum of conditions resulting from androgen excess, anovulation and metabolic syndrome. Patients with PCOS may see their primary care physicians for various presentations, including hirsutism, acne, menstrual irregularities, infertility, obesity, and psychiatric disorders such as anxiety and depression. Management of these patients should include screening for Type 2 diabetes mellitus, dyslipidaemia and hypertension. Treatment should be targeted to each patient's phenotype and personal expectations such as desire for pregnancy. Psychological well-being due to the effects on physical appearance is also an important consideration. Diet and exercise are major components in the management of patients with PCOS and obesity. The first-line therapy for fertility and metabolic syndrome in PCOS is lifestyle modification with diet and exercise, followed by pharmacological therapy.
C1 [Lua, Angelyn Chen Yin; King, Thomas F. J.] Changi Gen Hosp, Dept Endocrinol, 2 Simei St 3, Singapore 529889, Singapore.
   [How, Choon How] Changi Gen Hosp, Care & Hlth Integrat, Singapore, Singapore.
   [How, Choon How] SingHlth Duke NUS Acad Med Ctr, Family Med Acad Clin Programme, Singapore, Singapore.
   [King, Thomas F. J.] KK Womens & Childrens Hosp, Dept Reprod Med, Singapore, Singapore.
C3 Changi General Hospital; Changi General Hospital; KK Women's &
   Children's Hospital
RP King, TFJ (corresponding author), Changi Gen Hosp, Dept Endocrinol, 2 Simei St 3, Singapore 529889, Singapore.
EM Thomas_King@cgh.com.sg
RI King, Thomas/F-8482-2015
OI King, Thomas/0000-0002-0383-3433; Lua, Angelyn/0000-0001-8065-4642
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NR 11
TC 15
Z9 20
U1 1
U2 15
PU SINGAPORE MEDICAL ASSOC
PI SINGAPORE
PA 2985 JALAN BUKIT MERAH, #02-2C, SMF BUILDING, SINGAPORE, SINGAPORE
SN 0037-5675
J9 SINGAP MED J
JI Singap. Med. J.
PD NOV
PY 2018
VL 59
IS 11
BP 567
EP 571
DI 10.11622/smedj.2018135
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA HB1JL
UT WOS:000450778700003
PM 30498839
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Bakan, G
   Inci, FH
AF Bakan, Gulcan
   Inci, Fadime Hatice
TI The predictors of perceived stress in patients with type 2 diabetes in
   Turkey: styles of coping with stress and metabolic variables
SO INTERNATIONAL JOURNAL OF DIABETES IN DEVELOPING COUNTRIES
LA English
DT Article
DE Diabetes mellitus; Metabolic variables; Perceived stress; Coping
ID DISTRESS; DEPRESSION; HEALTH; ANXIETY; DETERMINANTS; MELLITUS; DISEASE;
   ADULTS; RISK
AB Background The study was conducted to examine the relationship between metabolic control variables and the coping strategies of type 2 DM patients with stress perception. Methods The study design was a descriptive and cross-sectional survey. The study sample consisted of 153 patients who reported to the Internal Medicine Outpatient Clinic. Data were collected using the descriptive characteristic form, perceived stress scale, and the coping styles inventory. Results Patients' mean BMI was 28.82 +/- 7.14, and the mean HbA1c level was 10.31 +/- 2.75. The prevalence of metabolic syndrome identified in patients with type 2 DM was 68%. A negative correlation was determined between perceived stress and age and the problem-focused coping method, whereas a positive correlation was found between BMI, number of accompanying chronic diseases, insulin use period, waist circumference, and emotion-focused coping method and perceived stress. Conclusions The variable that most affects the stress perception levels of patients with diabetes mellitus is problem-focused coping. Following these results, teaching patients how to use efficient techniques for stress coping and providing support for psychosocial care is necessary.
C1 [Bakan, Gulcan] Pamukkale Univ, Internal Med Nursing Dept, Fac Hlth Sci, Kinikli Campus,Univ St 11, TR-20160 Denizli, Turkey.
   [Inci, Fadime Hatice] Pamukkale Univ, Dept Publ Hlth Nursing, Fac Hlth Sci, Kinikli Campus,Univ St 11, TR-20160 Denizli, Turkey.
C3 Pamukkale University; Pamukkale University
RP Bakan, G (corresponding author), Pamukkale Univ, Internal Med Nursing Dept, Fac Hlth Sci, Kinikli Campus,Univ St 11, TR-20160 Denizli, Turkey.
EM gbakan@pau.edu.tr; hemel@pau.edu.tr
RI inci, fadime/V-7375-2017
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NR 53
TC 0
Z9 0
U1 0
U2 19
PU SPRINGER INDIA
PI NEW DELHI
PA 7TH FLOOR, VIJAYA BUILDING, 17, BARAKHAMBA ROAD, NEW DELHI, 110 001,
   INDIA
SN 0973-3930
EI 1998-3832
J9 INT J DIABETES DEV C
JI Int. Diabetes Dev. Ctries.
PD JAN
PY 2021
VL 41
IS 1
BP 164
EP 171
DI 10.1007/s13410-020-00842-3
EA AUG 2020
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA QT5XW
UT WOS:000561280900002
DA 2025-06-11
ER

PT J
AU Adachi, H
   Yamamoto, R
   Fujino, R
   Kanayama, D
   Sakagami, Y
   Akamine, S
   Marutani, N
   Yanagida, K
   Mamiya, Y
   Koyama, M
   Shigedo, Y
   Sugita, Y
   Mashita, M
   Nakano, N
   Watanabe, K
   Ikeda, M
   Kudo, T
AF Adachi, Hiroyoshi
   Yamamoto, Ryohei
   Fujino, Ryohei
   Kanayama, Daisuke
   Sakagami, Yukako
   Akamine, Shoshin
   Marutani, Noriko
   Yanagida, Kanta
   Mamiya, Yoshimasa
   Koyama, Masaki
   Shigedo, Yoshihisa
   Sugita, Yoshiro
   Mashita, Midori
   Nakano, Natsuko
   Watanabe, Kasumi
   Ikeda, Manabu
   Kudo, Takashi
TI Association of weekday-to-weekend sleep differences and stress response
   among a Japanese working population: a cross-sectional study
SO SLEEP MEDICINE
LA English
DT Article
DE Social jetlag; Sleep duration; Sleep debt; Stress response; Occupational
   health
ID SOCIAL JETLAG; METABOLIC SYNDROME; CHECK PROGRAM; DEPRESSION; ENDOCRINE;
   CHRONOTYPE
AB Objectives: To investigate the relationship between differences in weekday-to-weekend sleep habits and stress responses in a working population.
   Methods: This cross-sectional study used data from university workers on sleep habits, differences in sleep duration between weekdays and weekends, and each midpoint of the sleep phase on weekdays and weekends. Social jetlag was defined as the difference in the midpoint of the sleep phase between weekdays and weekends. In addition, the Brief Job Stress Questionnaire assessed stress responses and stress-related factors. To examine sleep-related factors affecting stress responses, regression analysis was performed with adjustments for age, sex, and stress-related factors.
   Results: Analyzed were 2,739 participants. Sleep duration differences obtained by subtracting sleep duration on weekdays from that on weekends, social jetlag, and weekday sleep duration were significantly associated with an increased risk of stress responses in a univariate linear regression model. Adjusting for age, sex, job stressors, and stressor buffering factors did not change this trend. However, when additionally adjusting for all sleep parameters, only sleep duration differences and weekday sleep duration were significantly associated with stress responses (beta 0.67 [95% CI 0.24, 1.10], p = 0.002), (-0.66 [-1.20, -0.13], p = 0.015).
   Conclusions: This study provided further evidence that weekday sleep duration and weekday-to-weekend sleep duration differences were independently associated with stress responses even when considering stress-related factors. However, social jetlag was not clearly associated with stress responses. Our findings highlighted the necessity of securing sufficient sleep for stress management and mental health promotion in a working population. (C) 2021 Elsevier B.V. All rights reserved.
C1 [Adachi, Hiroyoshi; Yamamoto, Ryohei; Kanayama, Daisuke; Sakagami, Yukako; Akamine, Shoshin; Marutani, Noriko; Yanagida, Kanta; Sugita, Yoshiro; Kudo, Takashi] Osaka Univ, Hlth & Counseling Ctr, 1-17 Machikaneyama Cho, Toyonaka, Osaka 5600043, Japan.
   [Adachi, Hiroyoshi; Kanayama, Daisuke; Mamiya, Yoshimasa; Koyama, Masaki; Shigedo, Yoshihisa; Mashita, Midori; Watanabe, Kasumi; Ikeda, Manabu; Kudo, Takashi] Osaka Univ, Dept Psychiat, Grad Sch Med, D3 2-2 Yamadaoka, Suita, Osaka 5650871, Japan.
   [Adachi, Hiroyoshi; Mamiya, Yoshimasa; Koyama, Masaki; Shigedo, Yoshihisa; Mashita, Midori; Nakano, Natsuko; Ikeda, Manabu] Osaka Univ Hosp, Sleep Med Ctr, 2-15 Yamadaoka, Suita, Osaka 5650871, Japan.
   [Fujino, Ryohei] Osaka Univ, Grad Sch Human Sci, 1-2 Yamadaoka, Suita, Osaka 5650871, Japan.
C3 The University of Osaka; The University of Osaka; The University of
   Osaka; The University of Osaka
RP Adachi, H (corresponding author), Osaka Univ, Hlth & Counseling Ctr, 1-17 Machikaneyama Cho, Toyonaka, Osaka 5600043, Japan.
EM hadachi@psy.med.osaka-u.ac.jp
RI YAMAMOTO, Ryohei/AAU-3059-2021
OI Akamine, Shoshin/0000-0001-6476-6222; Kudo, Takashi/0000-0003-2788-0653;
   Adachi, Hiroyoshi/0000-0001-9259-3197; YAMAMOTO,
   Ryohei/0000-0003-2610-9824
FU Innovation Platform for Society 5.0 from Japan Ministry of Education,
   Culture, Sports, Science and Technology [S004541]
FX The authors would like to thank the staff of Health and Counseling
   Center, Osaka University for providing the necessary support for the
   successful completion of this work. This research is partially supported
   by Innovation Platform for Society 5.0 from Japan Ministry of Education,
   Culture, Sports, Science and Technology (Code: S004541) .
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NR 32
TC 3
Z9 4
U1 0
U2 9
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1389-9457
EI 1878-5506
J9 SLEEP MED
JI Sleep Med.
PD JUN
PY 2021
VL 82
BP 159
EP 164
DI 10.1016/j.sleep.2021.04.006
EA APR 2021
PG 6
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA SJ6LD
UT WOS:000655643300024
PM 33933720
DA 2025-06-11
ER

PT J
AU Kamalesh, M
   Campbell, S
   Ligler, L
   Meda, M
   Eckert, GJ
   Sawada, S
AF Kamalesh, Masoor
   Campbell, Steffanie
   Ligler, Lindsay
   Meda, Mythily
   Eckert, George J.
   Sawada, Stephen
TI Metabolic Syndrome Does Not Predict an Increased Risk of Coronary
   Disease in Patients with Traditional Risk Factors Referred for Stress
   Imaging Study
SO METABOLIC SYNDROME AND RELATED DISORDERS
LA English
DT Article
ID AMERICAN-DIABETES-ASSOCIATION; CARDIOVASCULAR-DISEASE; HEART-DISEASE;
   ARTERY-DISEASE; TASK-FORCE; STATEMENT; MORTALITY; FRAMINGHAM; ADULTS
AB Background: The impact of metabolic syndrome on the prediction of coronary artery disease (CAD) in subjects with multiple traditional risk factors is unknown.
   Methods: We enrolled 2,626 consecutive subjects who underwent clinically indicated stress imaging studies using echocardiography or single-photon emission computed tomography (SPECT) myocardial perfusion. Patients with known CAD were excluded leaving 1256 subjects. Metabolic syndrome was defined by National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) criteria. The number of traditional risk factors and the presence of metabolic syndrome were compared with the results of stress imaging. Logistic regression analysis was used to assess the impact of metabolic syndrome on CAD prevalence in subjects with limited (<= 2) traditional risk factors and multiple (>= 3) risk factors.
   Results: Metabolic syndrome was present in 540 (43%) of subjects. Presence of metabolic syndrome was associated with a nonsignificant 3%-4% increase in overall prevalence of CAD. Metabolic syndrome did not increase the prevalence of CAD in those with multiple (>= 3) traditional risk factors (metabolic syndrome 25% vs. no metabolic syndrome 21%, P = 0.62) or in those with limited (<= 2) risk factors (metabolic syndrome 19% vs. no metabolic syndrome 16%, P = 0.13). The presence of multiple versus limited risk factors had poor accuracy for prediction of CAD with area under the receiver operating curve (ROC) = 0.52. Information on the presence or absence of metabolic syndrome did not improve identification of CAD, ROC area of 0.54, P = not significant (N.S.). None of the five individual components of metabolic syndrome showed significant association with CAD.
   Conclusions: The addition of metabolic syndrome to traditional risk factors does not increase the prevalence of CAD determined by stress imaging.
C1 Indiana Univ, Krannert Inst Cardiol, Indianapolis, IN 46204 USA.
   Indiana Univ, Roudebush VA Med Ctr, Indianapolis, IN 46204 USA.
C3 Indiana University System; Indiana University Indianapolis; US
   Department of Veterans Affairs; Veterans Health Administration (VHA);
   Richard L. Roudebush VA Medical Center; Indiana University System;
   Indiana University Indianapolis
RP Kamalesh, M (corresponding author), 1481 W 10th St, Indianapolis, IN 46202 USA.
EM masoor.kamalesh@med.va.gov
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NR 25
TC 3
Z9 3
U1 0
U2 2
PU MARY ANN LIEBERT INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-4196
J9 METAB SYNDR RELAT D
JI Metab. Syndr. Relat. Disord.
PD JUN
PY 2010
VL 8
IS 3
BP 223
EP 228
DI 10.1089/met.2009.0079
PG 6
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 605BK
UT WOS:000278322100006
PM 20156076
DA 2025-06-11
ER

PT J
AU Cunningham, C
   Brown, S
   Kaski, JC
AF Cunningham, C
   Brown, S
   Kaski, JC
TI Effects of transcendental meditation on symptoms and
   electrocardiographic changes in patients with cardiac syndrome X
SO AMERICAN JOURNAL OF CARDIOLOGY
LA English
DT Article
ID PROGRAM
AB Chest pain with normal coronary angiograms is often associated with chronic sympathetic activation anxiety, and depression, and is resistant to conventional antianginal treatment. The practice of transcendental meditation, a standard relaxation method for 3 months twice daily, significantly improved exercise tolerance, angina episodes, and quality of life in 9 women; the positive findings in this study warrant further research.
C1 Univ Westminster, London W1R 8AL, England.
   Univ London St Georges Hosp, London, England.
C3 University of Westminster; City St Georges, University of London; St
   Georges University London
RP Kaski, JC (corresponding author), Univ Westminster, London W1R 8AL, England.
RI Kaski, Juan Carlos/LKM-8031-2024
CR ALEXANDER CN, 1989, J PERS SOC PSYCHOL, V57, P950, DOI 10.1037/0022-3514.57.6.950
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NR 15
TC 33
Z9 36
U1 0
U2 2
PU EXCERPTA MEDICA INC
PI NEW YORK
PA 245 WEST 17TH STREET, NEW YORK, NY 10011 USA
SN 0002-9149
J9 AM J CARDIOL
JI Am. J. Cardiol.
PD MAR 1
PY 2000
VL 85
IS 5
BP 653
EP +
DI 10.1016/S0002-9149(99)00828-0
PG 4
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Cardiovascular System & Cardiology
GA 289ZB
UT WOS:000085650900025
PM 11078284
DA 2025-06-11
ER

PT J
AU Nobile, B
   Godin, O
   Gard, S
   Samalin, L
   Brousse, G
   Loftus, J
   Aubin, V
   Belzeaux, R
   Dubertret, C
   Le Strat, Y
   Mazer, N
   de Prémorel, A
   Roux, P
   Polosan, M
   Schwintzer, T
   Llorca, PM
   Biseul, I
   Etain, B
   Moirand, R
   Olié, E
   Haffen, E
   Leboyer, M
   Courtet, P
   Guillaume, S
   Icick, R
AF Nobile, Benedicte
   Godin, Ophelia
   Gard, Sebastien
   Samalin, Ludovic
   Brousse, Georges
   Loftus, Josephine
   Aubin, Valerie
   Belzeaux, Raoul
   Dubertret, Caroline
   Le Strat, Yann
   Mazer, Nicolas
   de Premorel, Alix
   Roux, Paul
   Polosan, Mircea
   Schwintzer, Thomas
   Llorca, Pierre-Michel
   Biseul, Isabelle
   Etain, Bruno
   Moirand, Remi
   Olie, Emilie
   Haffen, Emmanuel
   Leboyer, Marion
   Courtet, Philippe
   Guillaume, Sebastien
   Icick, Romain
CA FondaMental Adv Ctr Expertise
TI Physical and mental health status of former smokers and non-smokers
   patients with bipolar disorder
SO ACTA PSYCHIATRICA SCANDINAVICA
LA English
DT Article
DE addiction; bipolar disorder; former smokers; metabolic syndrome; tobacco
ID NATIONAL EPIDEMIOLOGIC SURVEY; FONDAMENTAL ADVANCED CENTERS; MAJOR
   DEPRESSIVE DISORDER; ALCOHOL-USE DISORDERS; CIGARETTE-SMOKING; TOBACCO
   USE; CESSATION; SCALE; IMPULSIVITY; PEOPLE
AB Objectives: Up to 70% individuals with bipolar disorder (BD) are lifetime tobacco smokers, a major modifiable risk factor for morbidity. However, quitting smoking is rarely proposed to individuals with BD, mainly because of fear of unfavorable metabolic or psychiatric changes. Evaluating the physical and mental impact of tobacco cessation is primordial. The aim of this study was to characterize the psychiatric and nonpsychiatric correlates of tobacco smoking status (never- vs. current vs. former smokers) in individuals with BD.Methods: 3860 individuals with ascertained BD recruited in the network of Fondamental expert centers for BD between 2009 and 2020 were categorized into current, former, and never tobacco smokers. We compared the sociodemographic and clinical characteristics assessed by standard instruments (e.g., BD type, current symptoms load, and non-psychiatric morbidity-including anthropometric and biological data) of the three groups using multinomial regression logistic models. Corrections for multiple testing were applied.Results: Current smokers had higher depression, anxiety, and impulsivity levels than former and never-smokers, and also higher risk of comorbid substance use disorders with a gradient from never to former to current smokers-suggesting shared liability. Current smokers were at higher risk to have a metabolic syndrome than never-smokers, although this was only evidenced in cases, who were not using antipsychotics.Conclusions: Tobacco smoking was associated with high morbidity level. Strikingly, as in the general population, quitting smoking seemed associated with their return to the never-smokers' levels. Our findings strongly highlight the need to spread strategies to treat tobacco addiction in the BD population.
C1 [Nobile, Benedicte; Olie, Emilie] CHU Montpellier, Dept Emergency Psychiat & Acute Care, Lapeyronie Hosp, Montpellier, France.
   [Nobile, Benedicte; Olie, Emilie; Courtet, Philippe; Guillaume, Sebastien] Univ Montpellier, Inst Genom Fonct, CNRS, INSERM, Montpellier, France.
   [Nobile, Benedicte; Godin, Ophelia; Gard, Sebastien; Samalin, Ludovic; Brousse, Georges; Loftus, Josephine; Aubin, Valerie; Belzeaux, Raoul; Dubertret, Caroline; Le Strat, Yann; Mazer, Nicolas; de Premorel, Alix; Roux, Paul; Polosan, Mircea; Schwintzer, Thomas; Llorca, Pierre-Michel; Biseul, Isabelle; Etain, Bruno; Moirand, Remi; Olie, Emilie; Haffen, Emmanuel; Leboyer, Marion; Courtet, Philippe; Guillaume, Sebastien; Icick, Romain] FondaMental Fdn, Creteil, France.
   [Godin, Ophelia] Univ Paris Est Creteil, Hop Univ H Mondor, AP HP, INSERM,U955,Dept Hosp Univ Psychiat & Addictol, Creteil, France.
   [Gard, Sebastien] Univ Bordeaux, Ctr Hosp Charles Perrens, France NutriNeuro, INRAE,UMR 1286,Pole Psychiat Gen & Univ, Bordeaux, France.
   [Brousse, Georges] Univ Clermont Auvergne, Inst Pascal, Dept Psychiat, CHU Clermont Ferrand,CNRS,Clermont Auvergne INP, Clermont Ferrand, France.
   [Loftus, Josephine; Aubin, Valerie] Ctr Hosp Princesse Grace, Pole Psychiat, Monaco, Monaco.
   [Belzeaux, Raoul] Aix Marseille Univ, Assistance Publ Hop Marseille, Pole Psychiat, INT UMR7289,CNRS, Marseille, France.
   [Dubertret, Caroline; Le Strat, Yann; Mazer, Nicolas; de Premorel, Alix] Univ Paris, Hop Louis Mourier, AP HP,Grp Hosp Univ AP HP Nord, Serv Psychiat & Addictol,INSERM,UMR1266, Colombes, France.
   [Roux, Paul] Univ Paris Saclay, Ctr Hosp Versailles, UVSQ,Pole Psychiat & Sante Mentale, CESP,UMR1018,DevPsy DisAP, Le Chesnay, France.
   [Polosan, Mircea] Univ Grenoble Alpes, Grenoble Inst Neurosci GIN, CHU Grenoble & Alpes, INSERM, Grenoble, France.
   [Schwintzer, Thomas] Ctr Psychotherap Nancy, Pole Hosp Univ Psychiat Adultes & Addictol Grand, Laxou, France.
   [Schwintzer, Thomas] Univ Lorraine, INSERM, IADI, U1254, Nancy, France.
   [Schwintzer, Thomas] Univ Lorraine, Fac Med, Vandoeuvre Les Nancy, France.
   [Biseul, Isabelle] Grp Hosp Univ Lariboisiere Fernand Widal, AP HP Nord, Dept Psychiat & Med Addictol, DMU Neurosci, Paris, France.
   [Etain, Bruno] Univ Paris Cite, INSERM, UMRS 1144, Paris, France.
   [Moirand, Remi; Haffen, Emmanuel] UBFC, CHU Besancon, Serv Psychiat Adulte, UFC,CIC 1431,INSERM,Lab Neurosci, Besancon, France.
   [Leboyer, Marion] Univ Paris Est Creteil, Hop Univ Henri Mondor,INSERM, AP HP,Federat Hosp Univ Med Precis Psychiat FHU A, Dept Med Univ Psychiat & Addictol DMU IMPACT, Paris, France.
C3 Universite de Montpellier; CHU de Montpellier; Institut National de la
   Sante et de la Recherche Medicale (Inserm); Centre National de la
   Recherche Scientifique (CNRS); Universite de Montpellier; Assistance
   Publique Hopitaux Paris (APHP); Universite
   Paris-Est-Creteil-Val-de-Marne (UPEC); Hopital Universitaire
   Henri-Mondor - APHP; Institut National de la Sante et de la Recherche
   Medicale (Inserm); Institut National de la Sante et de la Recherche
   Medicale (Inserm); Universite de Bordeaux; INRAE; Universite Clermont
   Auvergne (UCA); Polytechnic Institute of Clermont Auvergne; CHU Clermont
   Ferrand; Centre National de la Recherche Scientifique (CNRS); Centre
   National de la Recherche Scientifique (CNRS); CNRS - National Institute
   for Biology (INSB); Aix-Marseille Universite; Assistance
   Publique-Hopitaux de Marseille; Institut National de la Sante et de la
   Recherche Medicale (Inserm); Universite Paris Cite; Assistance Publique
   Hopitaux Paris (APHP); Hopital Universitaire Louis-Mourier - APHP;
   Institut National de la Sante et de la Recherche Medicale (Inserm);
   Centre Hospitalier de Versailles; Universite Paris Saclay; Communaute
   Universite Grenoble Alpes; Universite Grenoble Alpes (UGA); Institut
   National de la Sante et de la Recherche Medicale (Inserm); CEA; Centre
   National de la Recherche Scientifique (CNRS); CHU Grenoble Alpes;
   Institut National de la Sante et de la Recherche Medicale (Inserm);
   Universite de Lorraine; Universite de Lorraine; Assistance Publique
   Hopitaux Paris (APHP); Universite Paris Cite; Hopital Universitaire
   Lariboisiere-Fernand-Widal - APHP; Universite Paris Cite; Institut
   National de la Sante et de la Recherche Medicale (Inserm); Universite de
   Franche-Comte; CHU Besancon; Institut National de la Sante et de la
   Recherche Medicale (Inserm); Assistance Publique Hopitaux Paris (APHP);
   Universite Paris-Est-Creteil-Val-de-Marne (UPEC); Hopital Universitaire
   Henri-Mondor - APHP; Institut National de la Sante et de la Recherche
   Medicale (Inserm)
RP Nobile, B (corresponding author), Hop La Colombiere, IGF, 39 Ave Charles Flahault,BP 34493, F-34093 Montpellier 5, France.
EM benedicte.nobile@gmail.com
RI Polosan, Mircea/MGV-2270-2025; Icick, Romain/AAY-7305-2020; Roux,
   Paul/B-5795-2013; Etain, Bruno/L-6647-2017; Fond, Guillaume/D-7646-2011;
   Samalin, Ludovic/AAP-6362-2020; Le Strat, Yann/C-9848-2013; Belzeaux,
   Raoul/AGZ-3125-2022; haffen, emmanuel/R-2765-2017
OI Samalin, Ludovic/0000-0003-0740-4019; Nobile,
   Benedicte/0000-0002-2570-6996; haffen, emmanuel/0000-0002-4091-518X
FU Fondation FondaMental (RTRS Sant6 Mentale); ANR [ANR-11-IDEX-0004-02,
   ANR-10-COHO-10-01]; INSERM (Institut National de la Sant6 et de la
   Recherche M6dicale)
FX This work was funded by Fondation FondaMental (RTRS Sant6 Mentale), by
   the Investissements d'Avenir program managed by the ANR under reference
   ANR-11-IDEX-0004-02 and ANR-10-COHO-10-01, and by INSERM (Institut
   National de la Sant6 et de la Recherche M6dicale).
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NR 59
TC 2
Z9 2
U1 0
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0001-690X
EI 1600-0447
J9 ACTA PSYCHIAT SCAND
JI Acta Psychiatr. Scand.
PD APR
PY 2023
VL 147
IS 4
BP 373
EP 388
DI 10.1111/acps.13535
EA MAR 2023
PG 16
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA A7WF5
UT WOS:000942168300001
PM 36751870
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Goff, Z
   Sharma, V
   Varvari, I
AF Goff, Zoe
   Sharma, Vishal
   Varvari, Ioana
TI Managing diabetes in the psychiatric in-patient setting: knowledge,
   attitudes and skills of healthcare professionals
SO BJPSYCH BULLETIN
LA English
DT Article
DE Comorbidity; in-patient treatment; qualitative research; education and
   training; patients
ID METABOLIC SYNDROME; SCHIZOPHRENIA; PREVALENCE; DEPRESSION; MELLITUS
AB Aims and method There is currently a lack of monitoring and standardisation of diabetes care in the National Health Service (NHS) psychiatric in-patient setting. We surveyed healthcare professionals in psychiatric in-patient units across England to understand current diabetes care. A 13-item questionnaire was piloted via think-aloud interviews. The survey was completed by healthcare professionals across 19 wards in 11 NHS mental health trusts. Results were analysed via descriptive statistics and thematic analysis.Results Of 150 respondents, 98% agreed that addressing physical health needs was an important part of the mental health team's role; 68% agreed that they had adequate skills and knowledge to manage diabetes safely. Thematic analysis identified themes relating to individual, organisational and patient-level factors.Clinical implications Psychiatric admission could be used opportunistically to improve the healthcare disparities for people with comorbid diabetes and severe mental illness. This national survey highlights areas that need to be addressed to optimise diabetes care in this setting.
C1 [Goff, Zoe; Sharma, Vishal] Leeds & York Partnership NHS Fdn Trust, Old Age Psychiat, Leeds, England.
   [Goff, Zoe] Univ Leeds, Leeds, England.
   [Varvari, Ioana] South London & Maudsley NHS Trust, London, England.
C3 University of Leeds; South London & Maudsley NHS Trust
RP Goff, Z (corresponding author), Leeds & York Partnership NHS Fdn Trust, Old Age Psychiat, Leeds, England.; Goff, Z (corresponding author), Univ Leeds, Leeds, England.
EM zoe.goff@nhs.net
OI Goff, Zoe/0000-0002-4995-8012
CR All Party Parliamentary Group for Diabetes, 2018, Diabetes and Mental Health
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NR 15
TC 0
Z9 0
U1 0
U2 0
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 2056-4694
EI 2056-4708
J9 BJPSYCH BULL
JI BJPsych Bull.
PD DEC
PY 2024
VL 48
IS 6
BP 327
EP 333
DI 10.1192/bjb.2023.70
PG 7
WC Psychiatry
WE Emerging Sources Citation Index (ESCI)
SC Psychiatry
GA Q2F5C
UT WOS:001382906600011
PM 37667893
OA gold
DA 2025-06-11
ER

PT J
AU Huckans, M
   Fuller, BE
   Chalker, ALN
   Adams, M
   Loftis, JM
AF Huckans, Marilyn
   Fuller, Bret E.
   Chalker, Alison L. N.
   Adams, Madeleine
   Loftis, Jennifer M.
TI Plasma Inflammatory Factors Are Associated with Anxiety, Depression, and
   Cognitive Problems in Adults with and without Methamphetamine
   Dependence: An Exploratory Protein Array Study
SO FRONTIERS IN PSYCHIATRY
LA English
DT Article
DE anxiety; biological markers; depression; cognition; cytokines;
   inflammation; substance abuse
ID BLOOD-BRAIN-BARRIER; INCREASED SERUM-LEVELS; GLIAL-CELL MODULATORS;
   CHRONIC HEPATITIS-C; ALCOHOL-CONSUMPTION; ALZHEIMERS-DISEASE; METABOLIC
   SYNDROME; NUCLEUS-ACCUMBENS; IMMUNE ACTIVATION; ICAM-1 EXPRESSION
AB Objectives: It is hypothesized that immune factors influence addictive behaviors and contribute to relapse. The primary study objectives were to (1) compare neuropsychiatric symptoms across adults with active methamphetamine (MA) dependence, in early remission from MA dependence, and with no history of substance dependence, (2) determine whether active or recent MA dependence affects the expression of immune factors, and (3) evaluate the association between immune factor levels and neuropsychiatric symptoms.
   Methods: A cross-sectional study was conducted using between group comparisons and regression analyses to investigate associations among variables. Eighty-four adults were recruited into control (CTL) (n = 31), MA-active (n = 17), or MA-remission (n = 36) groups. Participants completed self-report measures of anxiety, depression, and memory complaints and objective tests of attention and executive function. Blood samples were collected, and a panel of immune factors was measured using multiplex technology.
   Results: Relative to CTLs, MA-dependent adults evidenced greater anxiety and depression during active use (p < 0.001) and remission (p < 0.007), and more attention, memory, and executive problems during remission (p < 0.01) but not active dependence. Regression analyses identified 10 immune factors (putatively associated with cytokine-cytokine receptor interactions) associated with anxiety, depression, and memory problems.
   Conclusion: While psychiatric symptoms are present during active MA dependence and remission, at least some cognitive difficulties emerge only during remission. Altered expression of a network of immune factors contributes to neuropsychiatric symptom severity.
C1 [Huckans, Marilyn; Fuller, Bret E.; Chalker, Alison L. N.; Adams, Madeleine; Loftis, Jennifer M.] VA Portland Hlth Care Syst, Res & Dev Serv, Portland, OR 97239 USA.
   [Huckans, Marilyn; Fuller, Bret E.] VA Portland Hlth Care Syst, Mental Hlth & Clin Neurosci Div, Portland, OR USA.
   [Huckans, Marilyn; Loftis, Jennifer M.] Oregon Hlth & Sci Univ, Dept Psychiat, Portland, OR 97201 USA.
   [Huckans, Marilyn; Loftis, Jennifer M.] Oregon Hlth & Sci Univ, Methamphetamine Abuse Res Ctr, Portland, OR 97201 USA.
C3 US Department of Veterans Affairs; Veterans Health Administration (VHA);
   VA Portland Health Care System; US Department of Veterans Affairs;
   Veterans Health Administration (VHA); VA Portland Health Care System;
   Oregon Health & Science University; Oregon Health & Science University
RP Huckans, M (corresponding author), VA Portland Hlth Care Syst, Res & Dev Serv, Portland, OR 97239 USA.
EM marilyn.huckans@va.gov; loftisj@ohsu.edu
RI Loftis, Jennifer/AAI-5054-2020
OI Loftis, Jennifer/0000-0003-1773-9365
FU NIDA NIH HHS [RC1 DA028537, P50 DA018165, R41 DA029345] Funding Source:
   Medline; BLRD VA [I01 BX002061] Funding Source: Medline
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NR 116
TC 43
Z9 45
U1 1
U2 12
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-0640
J9 FRONT PSYCHIATRY
JI Front. Psychiatry
PD DEC 18
PY 2015
VL 6
AR 178
DI 10.3389/fpsyt.2015.00178
PG 13
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA CZ2MJ
UT WOS:000366939000001
PM 26732994
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Nguyen-Rodriguez, ST
   Gallo, LC
   Isasi, CR
   Buxton, OM
   Thomas, KS
   Sotres-Alvarez, D
   Redline, S
   Castañeda, SF
   Carnethon, MR
   Daviglus, ML
   Perreira, KM
AF Nguyen-Rodriguez, Selena T.
   Gallo, Linda C.
   Isasi, Carmen R.
   Buxton, Orfeu M.
   Thomas, KaMala S.
   Sotres-Alvarez, Daniela
   Redline, Susan
   Castaneda, Sheila F.
   Carnethon, Mercedes R.
   Daviglus, Martha L.
   Perreira, Krista M.
TI Adiposity, Depression Symptoms and Inflammation in Hispanic/Latino
   Youth: Results From HCHS/SOL Youth
SO ANNALS OF BEHAVIORAL MEDICINE
LA English
DT Article
DE Depression Symptoms; Inflammation; Adiposity; Indirect Effects;
   Hispanic/Latino Youth
ID PLASMINOGEN-ACTIVATOR INHIBITOR-1; REACTIVE PROTEIN-LEVELS;
   PSYCHOLOGICAL DISTRESS; CARDIOMETABOLIC RISK; CARDIOVASCULAR RISK; SLEEP
   DURATION; LATINO YOUTH; CHILDREN; ANXIETY; HEALTH
AB Background Inflammation is implicated as one of many factors related to the development of chronic disease; thus, identifying its modifiable risk factors offers potential intervention targets to reduce risk.
   Purpose To investigate whether depression and anxiety symptoms may indirectly affect high-sensitivity C-reactive protein (hs-CRP) and plasminogen activator inhibitor-1 (PAI-1) through sleep duration and adiposity (i.e., percentage body fat and waist circumference).
   Methods Multiple regression analyses were performed on Hispanic Community Health Study/Study of Latinos Youth (ages 8-16 years) cross-sectional baseline data, which were weighted to adjust for sampling design. Data were collected at a clinical assessment, including fasting blood samples, self-report surveys, and objectively measured anthropometrics.
   Results Adjusting for sociodemographic covariates, depression symptoms were associated with log hs-CRP (beta =.011, p =.047) but not PAI-1 (p =.285). Percentage body fat and waist circumference were positively related to depression symptoms (p =.026 and p =.028, respectively) and log hs-CRP (p <.001 for both). When including adiposity in the hs-CRP model, the associations of depression symptoms with hs-CRP were attenuated and became nonsignificant. Monte Carlo confidence intervals (CIs) showed that the indirect effects from depression symptoms to CRP through percentage body fat (95% CI:.0006,.0119) and waist circumference (95% CI:.0004,.0109) were statistically significant.
   Conclusions Results indicate that the association between psychological distress and inflammation may occur indirectly through adiposity in Hispanic/Latino children. If findings are replicated in causal designs, reducing depression symptoms and adiposity among Hispanic/Latino children may be avenues for primary prevention of inflammation in later years.
C1 [Nguyen-Rodriguez, Selena T.] Calif State Univ Long Beach, Dept Hlth Sci, Long Beach, CA 90840 USA.
   [Gallo, Linda C.; Castaneda, Sheila F.] San Diego State Univ, Dept Psychol, San Diego, CA 92182 USA.
   [Isasi, Carmen R.] Albert Einstein Coll Med, Dept Epidemiol & Populat Hlth, New York, NY USA.
   [Buxton, Orfeu M.] Penn State Univ, Dept Biobehav Hlth, University Pk, PA 16802 USA.
   [Buxton, Orfeu M.] Harvard Univ, Dept Social & Behav Sci, Cambridge, MA 02138 USA.
   [Thomas, KaMala S.] Orange Cty Hlth Psychologists Inc, Irvine, CA USA.
   [Sotres-Alvarez, Daniela] Univ N Carolina, Dept Biostat, Chapel Hill, NC 27515 USA.
   [Carnethon, Mercedes R.] Northwestern Univ, Dept Prevent Med, Evanston, IL USA.
   [Daviglus, Martha L.] Univ Chicago, Dept Prevent Med, Chicago, IL 60637 USA.
   [Daviglus, Martha L.] Univ Chicago, Dept Med, 5841 S Maryland Ave, Chicago, IL 60637 USA.
   [Redline, Susan] Harvard Univ, Dept Med, Cambridge, MA 02138 USA.
   [Redline, Susan] Harvard Univ, Dept Neurol, Cambridge, MA 02138 USA.
   [Perreira, Krista M.] Univ N Carolina, Dept Social Med, Chapel Hill, NC 27515 USA.
C3 California State University System; California State University Long
   Beach; California State University System; San Diego State University;
   Yeshiva University; Pennsylvania Commonwealth System of Higher Education
   (PCSHE); Pennsylvania State University; Pennsylvania State University -
   University Park; Penn State Behrend; Harvard University; University of
   North Carolina; University of North Carolina Chapel Hill; Northwestern
   University; University of Chicago; University of Chicago; Harvard
   University; Harvard University; University of North Carolina; University
   of North Carolina Chapel Hill
RP Nguyen-Rodriguez, ST (corresponding author), Calif State Univ Long Beach, Dept Hlth Sci, Long Beach, CA 90840 USA.
EM selena.nguyen-rodriguez@csulb.edu
RI Sotres-Alvarez, Daniela/O-9085-2016; Castaneda, Sheila/AAK-3025-2020;
   Castaneda, Sheila/I-4132-2014
OI Castaneda, Sheila/0000-0002-1975-0544; Nguyen-Rodriguez,
   Selena/0000-0002-7418-5752; Buxton, Orfeu/0000-0001-5057-633X; Perreira,
   Krista/0000-0003-2906-0261
FU National Heart, Lung, and Blood Institute (NHLBI) [R01HL102130];
   National Heart, Lung, and Blood Institute [N01-HC65233, N01-HC65234,
   N01-HC65235, N01-HC65236, N01-HC65237]; NHLBI: National Center on
   Minority Health and Health Disparities; National Institute of Deafness
   and Other Communication Disorders; National Institute of Dental and
   Craniofacial Research; National Institute of Diabetes and Digestive and
   Kidney Diseases; National Institute of Neurological Disorders and
   Stroke; Office of Dietary Supplements
FX The Hispanic Community Health Study/Study of Latinos (HCHS/SOL) Youth
   was supported by National Heart, Lung, and Blood Institute (NHLBI; grant
   number R01HL102130). HCHS/SOL was supported by contracts from National
   Heart, Lung, and Blood Institute to the University of North Carolina
   (N01-HC65233), University of Miami (N01-HC65234), Albert Einstein
   College of Medicine (N01-HC65235), Northwestern University
   (N01-HC65236), and San Diego State University (N01-HC65237). The
   following Institutes/Centers/Offices contribute to the HCHS/SOL through
   a transfer of funds to NHLBI: National Center on Minority Health and
   Health Disparities, the National Institute of Deafness and Other
   Communication Disorders, the National Institute of Dental and
   Craniofacial Research, the National Institute of Diabetes and Digestive
   and Kidney Diseases, the National Institute of Neurological Disorders
   and Stroke, and the Office of Dietary Supplements. The content is solely
   the responsibility of the authors and does not necessarily represent the
   official views of the NHLBI or the National Institutes of Health.
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U1 0
U2 5
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EI 1532-4796
J9 ANN BEHAV MED
JI Ann. Behav. Med.
PD JUL
PY 2020
VL 54
IS 7
BP 529
EP 534
DI 10.1093/abm/kaz070
PG 6
WC Psychology, Multidisciplinary
WE Social Science Citation Index (SSCI)
SC Psychology
GA MG8GR
UT WOS:000546269800005
PM 32043152
OA Green Published
DA 2025-06-11
ER

PT J
AU Cocate, PG
   Natali, AJ
   de Oliveira, A
   Hermsdorff, HHM
   Peluzio, MDG
   Longo, GZ
   Buthers, JM
   dos Santos, EC
   de Oliveira, LL
   Alfenas, RDG
AF Cocate, Paula G.
   Natali, Antonio J.
   de Oliveira, Alessandro
   Hermsdorff, Helen Hermana M.
   Peluzio, Maria do Carmo G.
   Longo, Giana Z.
   Buthers, Jessica M.
   dos Santos, Eliziaria C.
   de Oliveira, Leandro L.
   Alfenas, Rita de Cassia G.
TI Usual dietary glycemic load is associated with cardiometabolic risk
   factors in physically active Brazilian middle-aged men
SO NUTRICION HOSPITALARIA
LA English
DT Article
DE Food habits; Carbohydrate; Triglycerides; High-density lipoproteins;
   Oxidative stress
ID HIGH-DENSITY-LIPOPROTEIN; OXIDATIVE STRESS; INDEX; CHOLESTEROL; OBESITY
AB Introduction: The effects of dietary glycemic load (GL) on cardiometabolic risk factors in physically active subjects are not completely known.
   Objective: This cross-sectional study assessed the association of habitual dietary GL with cardiometabolic risk factors in physically active Brazilian middle-aged men.
   Methods: One-hundred seventy-six subjects (Age: 50.6 +/- 5.0 years, BMI: 25.5 +/- 3.6 kg/m(2)) were evaluated. Anthropometry, lifestyle features, insulin resistance, oxidative stress biomarkers (8-iso-prostaglandin F2 alpha; 8-iso-PGF2 alpha and 8-hydroxydeoxyguanosine; 8-OHdG) and lipid profile were assessed. Dietary intake was estimated through a quantitative food frequency questionnaire.
   Results: The dietary GL was positively associated with free fatty acid concentrations (beta = 0.311, r(2) = 0.13, P-value = 0.034) and triglycerides/HDL cholesterol ratio (beta = 0.598, r(2) = 0.19, P-value = 0.028) regardless of confounding factors (central obesity, red meat consumption, age and energy intake). The oxidative stress biomarker, 8-0HdG, was associated with habitual dietary GL (beta = 0.432, r(2) = 0.11, P-value = 0.004), regardless of previous confounding factors plus excessive alcohol consumption, iron intake and current smoking status.
   Conclusions: The dietary GL was positively associated with lipid profile (free fatty acid concentrations and triglycerides/HDL cholesterol ratio) and oxidative stress biomarker (8-OHdG). These results indicate potential harmfulness of diet with higher GL to cardiometabolic risk factors in middle-aged men, even in physically active individuals.
C1 [Cocate, Paula G.; de Oliveira, Alessandro; Hermsdorff, Helen Hermana M.; Peluzio, Maria do Carmo G.; Longo, Giana Z.; Buthers, Jessica M.; dos Santos, Eliziaria C.; de Oliveira, Leandro L.; Alfenas, Rita de Cassia G.] Univ Fed Vicosa, Dept Nutr & Saude, BR-36570000 Vicosa, MG, Brazil.
   [Natali, Antonio J.] Univ Fed Vicosa, Dept Phys Educ, BR-36570000 Vicosa, MG, Brazil.
C3 Universidade Federal de Vicosa; Universidade Federal de Vicosa
RP Alfenas, RDG (corresponding author), Univ Fed Vicosa, Dept Nutr & Saude, Av PH Rolfs S-N, BR-36570000 Vicosa, MG, Brazil.
EM ralfenas@ufv.br
RI de Oliveira, Alessandro/ABF-5840-2021; LONGO, GIANA/AAX-6501-2020;
   Licursi de Oliveira, Leandro/D-3616-2009; Natali, Antonio
   Jose/C-1555-2013; Guedes Cocate, Paula/P-7621-2018; santos,
   Eliziaria/M-3107-2017; Hermsdorff, Helen Hermana Miranda/H-4525-2015
OI Licursi de Oliveira, Leandro/0000-0003-4353-7011; de Oliveira,
   Alessandro/0000-0003-3510-7070; Natali, Antonio
   Jose/0000-0002-4927-4024; Guedes Cocate, Paula/0000-0003-1208-6481;
   santos, Eliziaria/0000-0003-0825-5836; Alfenas,
   Rita/0000-0003-2290-1611; Hermsdorff, Helen Hermana
   Miranda/0000-0002-4441-6572; PELUZIO, MARIA DO CARMO
   GOUVEIA/0000-0003-4665-7043; Santos, Eliziaria
   Cardoso/0000-0002-3030-7746
FU Foundation for Research Support of the State of Minas Gerais (FAPEMIG,
   Brazil) [CDS-APQ-02189-10]
FX This study was supported by the Foundation for Research Support of the
   State of Minas Gerais (FAPEMIG, Brazil, CDS-APQ-02189-10). The authors
   thank the nursing staff for excellent technical assistance and the
   students, who helped in the fieldwork of the study. AJN, MCGP and RCGA
   are CNPq fellows.
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NR 37
TC 2
Z9 2
U1 0
U2 5
PU ARAN EDICIONES, S L
PI MADRID
PA C/ CASTELLO, 128, 1O, MADRID, 28006, SPAIN
SN 0212-1611
EI 1699-5198
J9 NUTR HOSP
JI Nutr. Hosp.
PD FEB
PY 2014
VL 29
IS 2
BP 444
EP 451
DI 10.3305/nh.2014.29.2.7121
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA AB6SC
UT WOS:000331918800029
PM 24528366
DA 2025-06-11
ER

PT J
AU Amato, G
   Khan, NS
   Maitra, R
AF Amato, George
   Khan, Nayaab S.
   Maitra, Rangan
TI A patent update on cannabinoid receptor 1 antagonists (2015-2018)
SO EXPERT OPINION ON THERAPEUTIC PATENTS
LA English
DT Review
DE CB1; cannabinoid; peripheral; antagonist; metabolic syndrome; NASH;
   obesity; endocannabinoid
ID ENDOCANNABINOID SYSTEM; OBESITY; OPPORTUNITIES; BLOCKERS; HEALTH
AB Introduction: The endocannabinoid system is an important regulator of various physiological processes. Preclinical and clinical studies indicate that attenuation of the endocannabinoid system via antagonism of the type 1 cannabinoid receptor (CB1) is an excellent strategy to treat obesity, metabolic syndrome and associated disorders. However, centrally acting antagonists of CB1 also produce adverse effects like depression and anxiety. Current efforts are geared towards discovery and optimization of antagonists and modulators of CB1 that have limited brain penetration.Areas covered: Several recent publications and patent applications support the development of peripherally acting CB1 receptor antagonists and modulators. In this review, recent patents and applications (2015-2018) are summarized and discussed.Expert opinion: Approximately 30 new inventions have been reported since 2015, along with 3 recent commercial deals, highlighting the importance of this class of therapeutics. Taken together, peripherally acting CB1 receptor antagonists and modulators are an emerging class of drugs for metabolic syndrome, non-alcoholic steatohepatitis (NASH) and other important disorders where this receptor has been implicated.
C1 [Amato, George; Khan, Nayaab S.; Maitra, Rangan] RTI Int, Ctr Drug Discovery, 3040 East Cornwallis Rd, Res Triangle Pk, NC 27709 USA.
C3 Research Triangle Institute
RP Maitra, R (corresponding author), RTI Int, Ctr Drug Discovery, 3040 East Cornwallis Rd, Res Triangle Pk, NC 27709 USA.
EM rmaitra@rti.org
RI Khan, Nayaab/AAD-3230-2022
OI Amato, George/0000-0002-3512-1895
FU National Institutes of Health [AA022235, DK100414]
FX The authors were supported by the research grants AA022235 and DK100414
   to Rangan Maitra from the National Institutes of Health.
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NR 83
TC 23
Z9 23
U1 0
U2 16
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1354-3776
EI 1744-7674
J9 EXPERT OPIN THER PAT
JI Expert Opin. Ther. Patents
PD APR 3
PY 2019
VL 29
IS 4
BP 261
EP 269
DI 10.1080/13543776.2019.1597851
PG 9
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA HX8XF
UT WOS:000467690000004
PM 30889997
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Chandola, T
   Brunner, E
   Marmot, M
AF Chandola, T
   Brunner, E
   Marmot, M
TI Chronic stress at work and the metabolic syndrome: prospective study
SO BMJ-BRITISH MEDICAL JOURNAL
LA English
DT Article
ID RISK-FACTORS; MULTIPLE IMPUTATION; BLOOD-PRESSURE; CORONARY RISK;
   ASSOCIATION; LINK; REWARD
AB Objectives To investigate the association between stress at work and the metabolic syndrome.
   Design Prospective cohort study investigating the association between work stress and the metabolic syndrome.
   Participants 10 308 men and women, aged 35-55, employed in 20 London civil service departments at baseline (the Whitehall 11 study); follow-up was an average of 14 years.
   Main outcome measures Work stress based on the iso-strain model, measured on four occasions (1985-99). Biological measures of the metabolic syndrome, based on the National Cholesterol Education Program definition, measured in 1999.
   Results A dose-response relation was found between exposure to work stressors over 14 years and risk of the metabolic syndrome, independent of other relevant risk factors. Employees with chronic work stress (three or more exposures) were more than twice as likely to have the syndrome than those without work stress (odds ratio adjusted for age and employment grade 2.25, 95% confidence interval 1.31 to 3.85).
   Conclusions Stress at work is an important risk factor for the metabolic syndrome. The study provides evidence for the biological plausibility of the link between psychosocial stressors from everyday life and heart disease.
C1 UCL, Dept Epidemiol & Publ Hlth, London WC1E 6BT, England.
C3 University of London; University College London
RP UCL, Dept Epidemiol & Publ Hlth, Mortimer St, London WC1E 6BT, England.
EM t.chandola@ucl.ac.uk
RI Brunner, Eric/H-2114-2011; Marmot, Michael/Y-3920-2019; Chandola,
   Tarani/I-3192-2013
OI Marmot, Michael/0000-0002-2431-6419; Brunner, Eric/0000-0002-0595-4474;
   Chandola, Tarani/0000-0002-1864-3413
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NR 25
TC 722
Z9 861
U1 1
U2 87
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 0959-535X
EI 1756-1833
J9 BMJ-BRIT MED J
JI BMJ-British Medical Journal
PD MAR 4
PY 2006
VL 332
IS 7540
BP 521
EP 524A
DI 10.1136/bmj.38693.435301.80
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 023WB
UT WOS:000236155800016
PM 16428252
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Sahebkar, A
   Pourghadamyari, H
   Moohebati, M
   Parizadeh, SMR
   Falsoleiman, H
   Dehghani, M
   Fazlinezhad, A
   Akhlaghi, S
   Tavallaie, S
   Paydar, R
   Ghayour-Mobarhan, M
   Ferns, GA
AF Sahebkar, Amirhossein
   Pourghadamyari, Hossein
   Moohebati, Mohsen
   Parizadeh, Seyed Mohammad Reza
   Falsoleiman, Homa
   Dehghani, Mashallah
   Fazlinezhad, Afsoon
   Akhlaghi, Saeed
   Tavallaie, Shima
   Paydar, Roghayeh
   Ghayour-Mobarhan, Majid
   Ferns, Gordon A.
TI A cross-sectional study of the association between heat shock protein 27
   antibody titers, pro-oxidant-antioxidant balance and metabolic syndrome
   in patients with angiographically-defined coronary artery disease
SO CLINICAL BIOCHEMISTRY
LA English
DT Article
DE Heat shock protein 27; Antibodies; Metabolic syndrome X; Coronary artery
   disease; Oxidative stress
ID HIGH-DENSITY-LIPOPROTEINS; SERUM ANTIBODIES; HUMAN
   HEAT-SHOCK-PROTEIN-60; CARDIOVASCULAR-DISEASE; OXIDATIVE STRESS; RISK;
   INFLAMMATION; HSP27; IDENTIFICATION; COMPLICATIONS
AB Objective: To investigate the association between serum antibody titers to Hsp27 (anti-Hsp27) and prooxidant-antioxidant balance (PAB) in patients with angiographically-defined coronary artery disease (CAD) with or without the metabolic syndrome (MS).
   Design: Subjects (n = 243) were classified into MS+ (n = 161) and MS (n = 82) subgroups, based on the AHA/NHBLI criteria.
   Results: Serum anti-Hsp27 titers were found to be significantly higher in the MS+ vs. MS- group. However, no significant difference was observed in serum PAB values. When assessed for individual components of MS, increased serum anti-Hsp27 was found to be higher in subgroups with elevated triglycerides, elevated blood pressure and reduced high-density lipoprotein cholesterol (HDL-C). Subgroups of patients with elevated triglycerides had higher PAB values. HDL-C was the only significant predictor of anti-Hsp27 in the population as a whole.
   Conclusion: The evidence from this investigation indicates the presence of elevated anti-Hsp27 in patients with concurrent CAD and MS compared to those with CAD alone. (C) 2011 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
C1 [Sahebkar, Amirhossein; Pourghadamyari, Hossein; Parizadeh, Seyed Mohammad Reza; Tavallaie, Shima; Paydar, Roghayeh; Ghayour-Mobarhan, Majid] Mashhad Univ Med Sci, Biochem & Nutr Res Ctr, Avicenna Res Inst, Mashhad, Iran.
   [Sahebkar, Amirhossein; Pourghadamyari, Hossein; Moohebati, Mohsen; Falsoleiman, Homa; Dehghani, Mashallah; Fazlinezhad, Afsoon; Tavallaie, Shima; Paydar, Roghayeh; Ghayour-Mobarhan, Majid] Mashhad Univ Med Sci, Cardiovasc Res Ctr, Avicenna Res Inst, Mashhad, Iran.
   [Moohebati, Mohsen; Falsoleiman, Homa; Dehghani, Mashallah; Fazlinezhad, Afsoon] Mashhad Univ Med Sci, Fac Med, Dept Cardiol, Mashhad, Iran.
   [Parizadeh, Seyed Mohammad Reza] Mashhad Univ Med Sci, Fac Med, Dept Biochem, Mashhad, Iran.
   [Ghayour-Mobarhan, Majid] Mashhad Univ Med Sci, Fac Med, Dept Nutr, Mashhad, Iran.
   [Ferns, Gordon A.] Univ Keele, Inst Sci & Technol Med, Guy Hilton Res Ctr, Stoke On Trent ST4 7QB, Staffs, England.
C3 Mashhad University of Medical Sciences; Mashhad University of Medical
   Sciences; Mashhad University of Medical Sciences; Mashhad University of
   Medical Sciences; Mashhad University of Medical Sciences; Keele
   University
RP Ghayour-Mobarhan, M (corresponding author), Mashhad Univ Med Sci, Biochem & Nutr Res Ctr, Avicenna Res Inst, Mashhad, Iran.
EM ghayourm@mums.ac.ir
RI Pourghadamyari, Hossein/ABC-9275-2020; Sahebkar,
   Amirhossein/B-5124-2018; mohebati, mohsen/AAR-2016-2021; Parizadeh,
   Seyed/AAM-9498-2021; Fazlinezhad, Afsoon/KIH-8257-2024;
   Ghayour-Mobarhan, Majid/AAY-5963-2020; Akhlaghi, Saeed/AAX-1767-2020
OI Akhlaghi, Saeed/0000-0002-1999-1209; pourghadamyari,
   hossein/0000-0002-4969-8572
FU Mashhad University of Medical Sciences
FX The authors acknowledge with grateful appreciation the financial support
   provided by the Vice Chancellor for Research at the Mashhad University
   of Medical Sciences.
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NR 48
TC 19
Z9 19
U1 0
U2 5
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0009-9120
EI 1873-2933
J9 CLIN BIOCHEM
JI Clin. Biochem.
PD DEC
PY 2011
VL 44
IS 17-18
BP 1390
EP 1395
DI 10.1016/j.clinbiochem.2011.09.011
PG 6
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA 855NE
UT WOS:000297570300006
PM 21986591
DA 2025-06-11
ER

PT J
AU Wirth, MD
   Burch, J
   Shivappa, N
   Violanti, JM
   Burchfiel, CM
   Fekedulegn, D
   Andrew, ME
   Hartley, TA
   Miller, DB
   Mnatsakanova, A
   Charles, LE
   Steck, SE
   Hurley, TG
   Vena, JE
   Hébert, JR
AF Wirth, Michael D.
   Burch, James
   Shivappa, Nitin
   Violanti, John M.
   Burchfiel, Cecil M.
   Fekedulegn, Desta
   Andrew, Michael E.
   Hartley, Tara A.
   Miller, Diane B.
   Mnatsakanova, Anna
   Charles, Luenda E.
   Steck, Susan E.
   Hurley, Thomas G.
   Vena, John E.
   Hebert, James R.
TI Association of a Dietary Inflammatory Index With Inflammatory Indices
   and Metabolic Syndrome Among Police Officers
SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
LA English
DT Article
ID CARDIOVASCULAR-DISEASE; SHIFT WORK; MARKERS; STRESS; ADULTS; HEALTH;
   SCORES
AB Objectives: To determine whether the dietary inflammatory index (DII) is associated with inflammatory or metabolic biomarkers and metabolic syndrome (MetSyn) among police officers. Methods: Cross-sectional data from the Buffalo Cardio-Metabolic Occupational Police Stress study were derived from saliva and fasting blood samples, anthropometric measurements, long-term shiftwork histories, and demographic, stress/depression, and food frequency questionnaires (FFQs). Metabolic syndrome was defined using standard criteria. Results: Officers in DII quartiles 2 to 4 were more likely to exceed a threshold of 3.0 mg/L for C-reactive protein (odds ratio [OR] = 1.88; 95% confidence interval [95% CI] = 1.02 to 3.45; OR = 2.17; 95% CI = 1.19 to 3.95; OR= 1.57; 95% CI= 0.85 to 2.88, respectively) compared with quartile 1. The glucose intolerance component of MetSyn was more prevalent among officers in DII quartile 4 than among those in quartile 1 (OR = 2.03; 95% CI = 1.08 to 3.82). Conclusions: A pro-inflammatory diet was associated with elevated CRP and with the glucose intolerance component of MetSyn.
C1 [Wirth, Michael D.; Burch, James; Shivappa, Nitin; Steck, Susan E.; Hurley, Thomas G.; Hebert, James R.] Univ S Carolina, Canc Prevent & Control Program, Columbia, SC 29208 USA.
   [Burch, James; Shivappa, Nitin; Steck, Susan E.; Hebert, James R.] Univ S Carolina, Dept Epidemiol & Biostat, Columbia, SC 29208 USA.
   [Burch, James] WJB Dorn VA Med Ctr, Columbia, SC USA.
   [Violanti, John M.] SUNY Buffalo, Dept Social & Prevent Med, Sch Publ Hlth & Hlth Profess, Buffalo, NY 14260 USA.
   [Burchfiel, Cecil M.; Fekedulegn, Desta; Andrew, Michael E.; Hartley, Tara A.; Mnatsakanova, Anna; Charles, Luenda E.] NIOSH, Biostat & Epidemiol Branch, Hlth Effects Lab Div, Ctr Dis Control & Prevent, Spokane, WA USA.
   [Miller, Diane B.] NIOSH, Toxicol & Mol Biol Branch, Hlth Effects Lab Div, Ctr Dis Control & Prevent, Spokane, WA USA.
   [Vena, John E.] Univ Georgia, Dept Epidemiol & Biostat, Coll Publ Hlth, Athens, GA 30602 USA.
   Med Univ S Carolina, Dept Publ Hlth Sci, Charleston, SC USA.
C3 University of South Carolina System; University of South Carolina
   Columbia; University of South Carolina System; University of South
   Carolina Columbia; State University of New York (SUNY) System;
   University at Buffalo, SUNY; Centers for Disease Control & Prevention -
   USA; National Institute for Occupational Safety & Health (NIOSH);
   Centers for Disease Control & Prevention - USA; National Institute for
   Occupational Safety & Health (NIOSH); University System of Georgia;
   University of Georgia; Medical University of South Carolina
RP Wirth, MD (corresponding author), Univ S Carolina, Canc Prevent & Control Program, 915 Greene St,Suite 200, Columbia, SC 29208 USA.
EM wirthm@mailbox.sc.edu
RI Hebert, James/IUO-5628-2023; Steck, Susan/G-5736-2013; Charles,
   Luenda/H-6008-2011; Wirth, Michael/C-6330-2013; Shivappa,
   Nitin/X-2215-2018
FU National Institute for Occupational Safety and Health [200-2003-01580];
   ASPIRE-II Grant from the University of South Carolina Office of
   Research; South Carolina Cancer Prevention and Control Research Network
   under Centers for Disease Control and Prevention [3U48DP001936-01];
   National Cancer Institute; Cancer Training Branch of the National Cancer
   Institute [K05 CA136975]
FX This work was supported by the National Institute for Occupational
   Safety and Health contract number 200-2003-01580. Dr Wirth's
   participation was supported through an ASPIRE-II Grant from the
   University of South Carolina Office of Research and by the South
   Carolina Cancer Prevention and Control Research Network funded under
   Cooperative Agreement Number 3U48DP001936-01 from the Centers for
   Disease Control and Prevention and the National Cancer Institute. Dr.
   Hebert is supported by an Established Investigator Award in Cancer
   Prevention and Control from the Cancer Training Branch of the National
   Cancer Institute (K05 CA136975). The findings and conclusions in this
   report are those of the authors and do not necessarily represent the
   views of the National Institute for Occupational Safety and Health,
   Centers for Disease Control and Prevention, or the National Cancer
   Institute. The authors declare no conflicts of interest.
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NR 20
TC 254
Z9 276
U1 1
U2 52
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1076-2752
EI 1536-5948
J9 J OCCUP ENVIRON MED
JI J. Occup. Environ. Med.
PD SEP
PY 2014
VL 56
IS 9
BP 986
EP 989
DI 10.1097/JOM.0000000000000213
PG 4
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA AP1JB
UT WOS:000341824000019
PM 25046320
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Pouwer, F
   Kupper, N
   Adriaanse, MC
AF Pouwer, Frans
   Kupper, Nina
   Adriaanse, Marcel C.
TI Does Emotional Stress Cause Type 2 Diabetes Mellitus? A Review from the
   European Depression in Diabetes (EDID) Research Consortium
SO DISCOVERY MEDICINE
LA English
DT Review
ID RISK-FACTORS; PSYCHOLOGICAL-FACTORS; PSYCHOSOCIAL FACTORS; METABOLIC
   SYNDROME; LIFE EVENTS; HOSTILITY; JAPANESE; ASSOCIATION; PREVALENCE;
   SYMPTOMS
AB According to the World Health Organization, approximately 220 million people worldwide have type 2 diabetes mellitus. Patients with type 2 diabetes not only have a chronic disease to cope with, they are also at increased risk for coronary heart disease, peripheral vascular disease, retinopathy, nephropathy, and neuropathy. The exact causes of type 2 diabetes are still not clear. Since the 17th century, it has been suggested that emotional stress plays a role in the etiology of type 2 diabetes mellitus. So far, review studies have mainly focused on depression as a risk factor for the development of type 2 diabetes mellitus. Yet, chronic emotional stress is an established risk factor for the development of depression. The present review provides an overview of mainly prospective epidemiological studies that have investigated the associations between different forms of emotional stress and the development of type 2 diabetes mellitus. Results of longitudinal studies suggest that not only depression but also general emotional stress and anxiety, sleeping problems, anger, and hostility are associated with an increased risk for the development of type 2 diabetes. Conflicting results were found regarding childhood neglect, life events, and work stress. It is important to emphasize that publication-bias may have occurred, resulting from "fishing-expeditions," where authors search their data for significant associations. Publication bias may also be caused by the tendency of reviewers and Editors to reject manuscripts with negative results for publication. It is therefore essential that research groups, who aim to conduct a new epidemiological cohort study, prospectively describe and publish the design of their study. Future research should focus on identifying mechanisms linking different forms of stress and incident type 2 diabetes. [Discovery Medicine 9(45):112-118, February 2010]
C1 [Pouwer, Frans; Kupper, Nina] Tilburg Univ, Ctr Res Psychol Somat Dis CoRPS, NL-5000 LE Tilburg, Netherlands.
   [Adriaanse, Marcel C.] Vrije Univ Amsterdam, Dept Hlth Sci, Sect Prevent & Publ Hlth, Amsterdam, Netherlands.
   [Adriaanse, Marcel C.] Vrije Univ Amsterdam, EMGO Inst Hlth & Care Res, Amsterdam, Netherlands.
C3 Tilburg University; Vrije Universiteit Amsterdam; Vrije Universiteit
   Amsterdam
RP Pouwer, F (corresponding author), Tilburg Univ, Ctr Res Psychol Somat Dis CoRPS, NL-5000 LE Tilburg, Netherlands.
RI Adriaanse, Marieke/AFQ-8371-2022; Kupper, Nina/B-6337-2011
OI Pouwer, Frans/0000-0002-8172-9818; Adriaanse, Marcel/0000-0002-5085-6662
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NR 39
TC 165
Z9 190
U1 1
U2 40
PU DISCOVERY MEDICINE
PI TIMONIUM
PA 10 GERARD AVE, STE 201, TIMONIUM, MD 21093 USA
SN 1539-6509
EI 1944-7930
J9 DISCOV MED
JI Discov. Med.
PD FEB
PY 2010
VL 9
IS 45
BP 112
EP 118
PG 7
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA V27UI
UT WOS:000208637700006
PM 20193636
DA 2025-06-11
ER

PT J
AU Martin-Garcia, E
   Domingo-Rodriguez, L
   Lutz, B
   Maldonado, R
   de Azua, IR
AF Martin-Garcia, Elena
   Domingo-Rodriguez, Laura
   Lutz, Beat
   Maldonado, Rafael
   de Azua, Inigo Ruiz
TI Cannabinoid type-1 receptors in CaMKII neurons drive impulsivity in
   pathological eating behavior
SO MOLECULAR METABOLISM
LA English
DT Article
DE Endocannabinoid system; Cannabinoid type 1 receptor (CB1); Impulsivity;
   Feeding behavior; Obesity; Metabolic syndrome; Food addiction
ID FOOD ADDICTION; RISK-FACTORS; ENDOCANNABINOID SYSTEM; CARDIOMETABOLIC
   RISK; OVERWEIGHT PATIENTS; ENERGY-BALANCE; OBESE-PATIENTS; CB1 RECEPTOR;
   WEIGHT; RIMONABANT
AB Objectives: Overconsumption of palatable food and energy accumulation are evolutionary mechanisms of survival when food is scarce. These innate mechanisms becom detrimental in obesogenic environment promoting obesity and related comorbidities, including mood disorders. This study aims at elucidating the role of the endocannabinoid system in energy accumulation and hedonic feeding. Methods: We applied a genetic strategy to reconstitute cannabinoid type-1 receptor (CB1) expression at functional levels specifically in CaMKII+ neurons (CaMKII-CB1-RS) and adipocytes (Ati-CB1-RS), respectively, in a CB1 deficient background. Results: Rescued CB1 expression in CaMKII+ neurons, but not in adipocytes, promotes feeding behavior, leading to fasting-induced hyperphagia, increased motivation, and impulsivity to palatable food seeking. In a diet-induced obesity model, CB1 re-expression in CaMKII+ neurons, but not in adipocytes, compared to complete CB1 deficiency, was sufficient to largely restore weight gain, food intake without any effect on glucose intolerance associated with high-fat diet consumption. In a model of glucocorticoid-mediated metabolic syndrome, CaMKII-CB1-RS mice showed all metabolic alterations linked to the human metabolic syndrome except of glucose intolerance. In a binge-eating model mimicking human pathological feeding, CaMKII-CB1-RS mice showed increased seeking and compulsive behavior to palatable food, suggesting crucial roles in foraging and an enhanced susceptibility to addictive-like eating behaviors. Importantly, other contingent behaviors, including increased cognitive flexibility and reduced anxiety-like behaviors, but not depressive-like behaviors, were also observed. Conclusions: CB1 in CaMKII+ neurons is instrumental in feeding behavior and energy storage under physiological conditions. The exposure to risk factors (hypercaloric diet, glucocorticoid dysregulation) leads to obesity, metabolic syndrome, binge-eating and food addiction. (c) 2025 The Authors. Published by Elsevier GmbH. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
C1 [Martin-Garcia, Elena; Domingo-Rodriguez, Laura; Maldonado, Rafael] Univ Pompeu Fabra, Dept Expt & Hlth Sci, Lab Neuropharmacol Neurophar, Barcelona 08003, Spain.
   [Martin-Garcia, Elena; Domingo-Rodriguez, Laura; Maldonado, Rafael] Univ Autonoma Barcelona, Dept Psychobiol & Methodol Hlth Sci, Bellaterra 08193, Spain.
   [Martin-Garcia, Elena; Maldonado, Rafael] Hosp del Mar Med Res Inst IMIM, Barcelona, Spain.
   [Lutz, Beat; de Azua, Inigo Ruiz] Leibniz Inst Resilience Res, D-55122 Mainz, Germany.
   [Lutz, Beat; de Azua, Inigo Ruiz] Johannes Gutenberg Univ Mainz, Univ Med Ctr, Inst Physiol Chem, D-55128 Mainz, Germany.
C3 Pompeu Fabra University; Autonomous University of Barcelona; Hospital
   del Mar Research Institute; Hospital del Mar; Johannes Gutenberg
   University of Mainz
RP de Azua, IR (corresponding author), Leibniz Inst Resilience Res, D-55122 Mainz, Germany.
EM inigo.azua@lir-mainz.de
RI Lutz, Beat/AFK-6229-2022; Martín-García, Elena/GLN-3219-2022
FU EU-FP7 REPROBESITY; Spanish "Ministerio de Ciencia, Innovacion y
   Universidades, Agencia Estatal de Investigacion (AEI)" [PID2020-
   120029GB-I00/MICIN/AEI/10.13039/501100011033, RD21/0009/0019,
   PDI2023-1511680B-C21]; Spanish "Instituto de Salud Carlos III,
   RETICS-RTA" [RD12/0028/0023]; Generalitat de Catalunya, AGAUR [2017
   SGR-669]; ICREA-Academia; Spanish "Ministerio de Sanidad, Servicios
   Sociales e Igualdad"; Plan Nacional Sobre Drogas of the Spanish Ministry
   of Health; La Caixa Health [LCR/PR/HR22/5240017]; Spanish "Ministerio de
   Ciencia e Innovacion" (ERA-NET) [PCI2021-122073-2A];  [CRC1193]; 
   [HEALTHF2-2008-223713];  [PNSD-2017I068];  [PNSD-2019I006]; 
   [PNSD-2023I040]
FX This work was supported by CRC1193 "Neurobiology of resilience" to B.L.;
   EU-FP7 REPROBESITY (HEALTHF2-2008-223713 to B.L.) ; Spanish "Ministerio
   de Ciencia, Innovacion y Universidades, Agencia Estatal de Investigacion
   (AEI)" (PID2020- 120029GB-I00/MICIN/AEI/10.13039/501100011033,
   RD21/0009/0019 and PDI2023-1511680B-C21) , the Spanish "Instituto de
   Salud Carlos III, RETICS-RTA" (#RD12/0028/0023) , the "Generalitat de
   Catalunya, AGAUR" (#2017 SGR-669) , "ICREA-Academia" (#2015) and the
   Spanish "Ministerio de Sanidad, Servicios Sociales e Igualdad", "Plan
   Nacional Sobre Drogas of the Spanish Ministry of Health"
   (#PNSD-2017I068) to R.M., "la Caixa Health" LCR/PR/HR22/5240017 to R.M.
   and E.M-G., "Plan Nacional Sobre Drogas of the Spanish Ministry of
   Health" (#PNSD-2019I006, #PNSD-2023I040) and Spanish "Ministerio de
   Ciencia e Innovacion" (ERA-NET) PCI2021-122073-2A to E.M-G. We are very
   grateful to L. Mediavilla and K. Sawa for their work in the reporter
   mice; A. Conrad, M. Linares, R. Martin, D. Real and F. Porron for their
   technical support. We acknowledgment the contribution of M. Plenikowski
   with the preparation of the figures.
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NR 62
TC 0
Z9 0
U1 2
U2 2
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2212-8778
J9 MOL METAB
JI Mol. Metab.
PD FEB
PY 2024
VL 92
AR 102096
DI 10.1016/j.molmet.2025.102096
EA JAN 2025
PG 13
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA T2F5D
UT WOS:001403231600001
PM 39788291
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Kempel, MK
   Winding, TN
   Böttcher, M
   Andersen, JH
AF Kempel, Mia Klinkvort
   Winding, Trine Nohr
   Bottcher, Morten
   Andersen, Johan Hviid
TI Subjective social status and cardiometabolic risk markers in young
   adults
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE Socioeconomic position; Social inequality; Composite cardiometabolic
   risk score; Epidemiology; Young adults; MacArthur scale
ID CARDIOVASCULAR-DISEASE; HEALTH; INEQUALITIES; CHILDHOOD; DISADVANTAGE;
   ASSOCIATIONS; INDICATORS; PARADOX; STRESS; INCOME
AB Background: Low subjective social status (SSS), the perceived status in the social hierarchy, is associated with cardiometabolic risk in middle-aged and older adults. However, most studies are cross-sectional and very little is known about the association in adolescence and young adulthood. The aims of this study were; a) to prospectively investigate the association between SSS at ages 15 and 28 and cardiometabolic risk at age 28-30 and b) to examine if such an association was independent of smoking, physical activity and objective measures of social position.Methods: The study used questionnaire information at ages 15 and 28 from the West Jutland Cohort Study (N = 3681), health measurements from a sub-sample of the cohort (N = 264, age 28-30, 50% women) and information from population-based national registers. The independent variable was a measure of SSS evaluated by a 10-rung ladder scale and dichotomized at the 25th percentile of data from the cohort study population. The outcome measure was a composite score of cardiometabolic risk including measures of lipids, inflammation, blood pressure and glucose-metabolism. Co-variates included smoking, physical activity, childhood and adulthood socioeconomic position. Sex-stratified linear regression analyses were performed to evaluate the associations between SSS and cardiometabolic risk.Results: In both sexes, low SSS at age 28, but not at age 15, was significantly associated with increased cardiometabolic risk at age 28-30. Neither smoking, physical activity, childhood or adulthood objective socioeconomic position fully explained the associations. Conclusion: In young adulthood, SSS was inversely related to cardiometabolic risk after accounting for smoking, physical activity and objective measures of socioeconomic position. These findings suggest that SSS could play a role in the social disparities in cardiometabolic risk in addition to traditional measures of socioeconomic position.
C1 [Kempel, Mia Klinkvort; Winding, Trine Nohr; Bottcher, Morten; Andersen, Johan Hviid] Aarhus Univ, Dept Clin Med, Fac Hlth, Aarhus, Denmark.
   [Kempel, Mia Klinkvort; Winding, Trine Nohr; Andersen, Johan Hviid] Univ Res Clin, Goedstrup Hosp, Danish Rarnazzini Ctr, Dept Occupat Med, Herning, Denmark.
   [Bottcher, Morten] Univ Res Clin, Dept Cardiol, Goedstrup Hosp, Cardiovasc Res Unit, Herning, Denmark.
C3 Aarhus University
RP Kempel, MK (corresponding author), Gl Landevej 61, DK-7400 Herning, Denmark.
EM mialaurs@rm.dk
RI Andersen, Johan/AAI-2086-2019; Bottcher, M./AAI-8098-2020
OI Winding, Trine Nohr/0000-0002-2448-0403; Hviid Andersen,
   Johan/0000-0003-1638-8276; Kempel, Mia Klinkvort/0000-0003-1669-5110;
   Bottcher, Morten/0000-0002-2116-2370
FU Karen Elise Jensen Foundation; Health Research Foundation of Central
   Denmark Region; Research Foundation Goedstrup Hospital
FX This work was supported by The Karen Elise Jensen Foundation, Health
   Research Foundation of Central Denmark Region and the Research
   Foundation Goedstrup Hospital. None of the funding organizations had any
   influence on study design, analysis or interpretation of data.
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NR 53
TC 7
Z9 7
U1 1
U2 5
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
EI 1873-3360
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD MAR
PY 2022
VL 137
AR 105666
DI 10.1016/j.psyneuen.2022.105666
EA JAN 2022
PG 11
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA 0U8GO
UT WOS:000787885900001
PM 35038663
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Tsai, AG
   Wadden, TA
   Sarwer, DB
   Berkowitz, RI
   Womble, LG
   Hesson, LA
   Phelan, S
   Rothman, R
AF Tsai, Adam Gilden
   Wadden, Thomas A.
   Sarwer, David B.
   Berkowitz, Robert I.
   Womble, Leslie G.
   Hesson, Louise A.
   Phelan, Suzanne
   Rothman, Rebecca
TI Metabolic syndrome and health-related quality of life in obese
   individuals seeking weight reduction
SO OBESITY
LA English
DT Article
ID CARDIOVASCULAR-DISEASE; INSULIN-RESISTANCE; RISK; INVENTORY; TRIAL;
   SF-36
AB Background: No previous research has examined the association between metabolic syndrome (MetSyn) and health-related quality of life (HRQoL) using standard criteria for defining MetSyn. We hypothesized that MetSyn would be associated with lower HRQoL on measures of physical and mental health.
   Methods and Procedures: Participants were 361 individuals in two randomized weight loss trials. MetSyn was defined by the National Cholesterol Education Panel criteria. The Medical Outcomes Study, Short Form-36 (SF-36) was used to assess HRQoL. Differences in HRQoL and in clinical and psychosocial characteristics were compared among participants with and without MetSyn. Multiple regression was used to determine predictors of HRQoL.
   Results: MetSyn was associated with lower scores on the physical function and general health subscales of the SF-36 and on the physical component summary (PCS) score. This association remained after controlling for age or depression but was eliminated by controlling for BMI. MetSyn was not associated with lower mental quality of life, a higher depression score, tobacco or alcohol use, or a higher rate of psychosocial stressors.
   Discussion: Individuals with MetSyn reported lower HRQoL. This appeared to be an effect of increased weight, rather than a unique effect of MetSyn. Larger studies are needed to assess whether MetSyn may have an independent effect on HRQoL.
C1 [Tsai, Adam Gilden; Wadden, Thomas A.; Sarwer, David B.; Berkowitz, Robert I.; Womble, Leslie G.; Hesson, Louise A.; Rothman, Rebecca] Univ Penn, Sch Med, Ctr Weight & Eating Disorders, Philadelphia, PA 19104 USA.
   [Phelan, Suzanne] Brown Med Sch, Miriam Hosp, Weight Control & Diabet Res Ctr, Providence, RI 02906 USA.
C3 University of Pennsylvania; Lifespan Health Rhode Island; Miriam
   Hospital; Brown University
RP Tsai, AG (corresponding author), Univ Penn, Sch Med, Ctr Weight & Eating Disorders, Philadelphia, PA 19104 USA.
EM gildena@mail.med.upenn.edu
RI Cobden, David/AGL-5940-2022
OI Phelan, Suzanne/0000-0003-2260-0499; Wadden, Thomas/0000-0002-0438-4609
FU NICHD NIH HHS [5-K12-HD043459-04] Funding Source: Medline; NIDDK NIH HHS
   [DK065018, DK56124] Funding Source: Medline
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NR 26
TC 44
Z9 49
U1 1
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1930-7381
EI 1930-739X
J9 OBESITY
JI Obesity
PD JAN
PY 2008
VL 16
IS 1
BP 59
EP 63
DI 10.1038/oby.2007.8
PG 5
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 253YU
UT WOS:000252554300011
PM 18223613
OA Bronze
DA 2025-06-11
ER

PT J
AU Wu, XY
   Wei, DD
   Guo, Y
   Zhou, YL
   Cao, QQ
   Yuan, PC
   Han, GZ
   Chen, ZW
   Chen, TM
   Han, ER
   Lou, HL
   Huo, WQ
   Wang, CJ
   Huang, S
   Zeng, X
   Mao, ZX
AF Wu, Xueyan
   Wei, Dandan
   Guo, Yao
   Zhou, Yilin
   Cao, Qingqing
   Yuan, Pengcheng
   Han, Guozhen
   Chen, Zhiwei
   Chen, Taimeng
   Han, Erbao
   Lou, Huilin
   Huo, Wenqian
   Wang, Chongjian
   Huang, Shan
   Zeng, Xin
   Mao, Zhenxing
TI Unveiling the link: Neonicotinoids and elevated cardiometabolic risks in
   Chinese rural residents - from a prospective cohort study combing
   mendelian randomization study
SO JOURNAL OF HAZARDOUS MATERIALS
LA English
DT Article
DE Neonicotinoids; Mixed exposure; Cardiometabolic risk; Mendelian
   randomization; Rural population
ID PHARMACEUTICALS; INSECTICIDE; EXPOSURE; INFLAMMATION; MODULATION;
   STRESS; CANCER; FIELD
AB Purpose: This study aimed to evaluate the relationships of separate and mixed exposure of neonicotinoids on cardiometabolic risk at baseline and follow-up and its change over 3 years, and further explore whether inflammatory markers levels and platelet traits (PLT) mediate these relationships. Methods: In this prospective cohort study from the Henan Rural Cohort Study, 2315 participants were involved at baseline, and 1841 participants completed cardiometabolic risk predictors determinations during the 3-year follow-up. Each neonicotinoid pesticide was normalized to imidacloprid (IMI eq ) using the relative potency factor approach. Quantile-based g-computation (Qgcomp) regression was used to evaluate the effect of the mixtures of neonicotinoids mediation analysis was employed to explore whether inflammatory markers levels and platelet traits mediated these relationships. A two-sample mendelian randomization (MR) study was further used to causal association. Results: Qgcomp regression revealed a statistically positive relationship between neonicotinoids mixture exposure and cardiometabolic risk score at baseline and follow-up over 3 years. Both neutrophils/monocytes and PLT were mediators in the relationship between IMI eq and cardiometabolic risk score at baseline and follow-up over 3 years. The causal risk effect of pesticide exposure were 2.50 (0.05, 4.95) and 5.24 (1.28, 9.19) for cardiometabolic risk indicators including insulin resistance and triglyceride, respectively. Nevertheless, there was no correlation discovered between pesticide exposure and other markers of cardiometabolic risk. Conclusion: Neonicotinoid insecticides exposure was connected to an increased cardiometabolic risk, especially in individuals with T2DM. Furthermore, inflammatory markers and PLT seem to be two vital mediators of these associations. Additionally, genetic evidence on pesticide exposure and cardiometabolic risk still needs to be validated by multiregional and multiethnic GWAS studies.
C1 [Wu, Xueyan; Wei, Dandan; Guo, Yao; Zhou, Yilin; Han, Guozhen; Chen, Zhiwei; Chen, Taimeng; Han, Erbao; Mao, Zhenxing] Zhengzhou Univ, Coll Publ Hlth, Dept Epidemiol & Biostat, 100 Kexue Ave, Zhengzhou 450001, Henan, Peoples R China.
   [Cao, Qingqing; Yuan, Pengcheng] Zhengzhou Univ, Coll Publ Hlth, Dept Occupat & Environm Hlth Sci, Zhengzhou, Henan, Peoples R China.
   [Huang, Shan] Henan Inst Food & Salt Ind Inspect Technol, Zhengzhou, Henan, Peoples R China.
   [Zeng, Xin] Zhengzhou Univ, Sch Publ Hlth, Zhengzhou, Henan, Peoples R China.
C3 Zhengzhou University; Zhengzhou University; Zhengzhou University
RP Mao, ZX (corresponding author), Zhengzhou Univ, Coll Publ Hlth, Dept Epidemiol & Biostat, 100 Kexue Ave, Zhengzhou 450001, Henan, Peoples R China.
EM mzx@zzu.edu.cn
RI Cao, Qingqing/ACO-1149-2022; huo, wenqian/O-1974-2013
OI Huo, Wenqian/0000-0002-7898-093X
FU National Key Research and Development Program of China [2023YFC2506505];
   National Natural Science Foundation of China [42177415, 21806146];
   Post-doctoral Science Foundation of China [2020T130604, 2021M702934];
   Science and Technique Foundation of Henan Province [232102411006,
   232102310213, 212102310074]; Scientific and Technological Innovation of
   Colleges and Universities in Henan Province Talent Support Program
   [22HASTIT044]; Young Backbone Teachers Program of Colleges and
   Universities in Henan Province [2021GGJS015]; Excellent Youth
   Development Foundation of Zhengzhou University [2021ZDGGJS057]
FX The authors thank all of the participants, coordinators, and
   administrators for their support during the research. This research was
   supported by the National Key Research and Development Program of China
   (Grant No.: 2023YFC2506505), the National Natural Science Foundation of
   China (Grant No.: 42177415, 21806146), the Post-doctoral Science
   Foundation of China (Grant No.: 2020T130604, 2021M702934), the Science
   and Technique Foundation of Henan Province (Grant No. 232102411006,
   232102310213, 212102310074), the Scientific and Technological Innovation
   of Colleges and Universities in Henan Province Talent Support Program
   (Grant No. 22HASTIT044), the Young Backbone Teachers Program of Colleges
   and Universities in Henan Province (Grant No. 2021GGJS015), and the
   Excellent Youth Development Foundation of Zhengzhou University (Grant
   No. 2021ZDGGJS057).
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NR 67
TC 3
Z9 3
U1 14
U2 31
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0304-3894
EI 1873-3336
J9 J HAZARD MATER
JI J. Hazard. Mater.
PD SEP 5
PY 2024
VL 476
AR 135170
DI 10.1016/j.jhazmat.2024.135170
EA JUL 2024
PG 12
WC Engineering, Environmental; Environmental Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering; Environmental Sciences & Ecology
GA YN2C6
UT WOS:001269091800001
PM 39002477
DA 2025-06-11
ER

PT J
AU Jayawardena, R
   Sooriyaarachchi, P
   Misra, A
AF Jayawardena, Ranil
   Sooriyaarachchi, Piumika
   Misra, Anoop
TI Abdominal obesity and metabolic syndrome in South Asians: prevention and
   management
SO EXPERT REVIEW OF ENDOCRINOLOGY & METABOLISM
LA English
DT Review
DE Metabolic syndrome; abdominal obesity; South Asia; prevention;
   management; risk factors; prevalence
ID RANDOMIZED CONTROLLED-TRIAL; INTERNATIONAL-DIABETES-FEDERATION;
   PHYSICAL-ACTIVITY; RISK-FACTORS; INSULIN-RESISTANCE; ADIPOSE-TISSUE;
   NONCOMMUNICABLE DISEASES; CARDIOVASCULAR-DISEASE; OXIDATIVE STRESS;
   WEIGHT-LOSS
AB Introduction: The prevalence of metabolic syndrome (MetS) and abdominal obesity are escalating in South Asian countries. It is well established that MetS is associated with increased risk for both Type 2 diabetes mellitus and cardiovascular diseases. South Asians have an increased risk of MetS due to a variety of factors including unhealthy lifestyle and their unique body composition.
   Areas covered: In this review, we discuss the prevalence, associated risk factors, and evidence-based preventive and curative strategies for MetS and abdominal obesity in South Asians. A literature search through PubMed (R), Web of Science (R), and Scopus (R) was performed for studies published before 31(st) April 2021. A combination of the following keywords was used with the names of the individual South Asian countries: 'metabolic syndrome,' 'syndrome X,' 'abdominal obesity,' 'central obesity,' 'visceral obesity,' 'prevention,' and 'management.'
   Expert opinion: According to current evidence, MetS and abdominal obesity are highly prevalent among South Asians. Several risk factors, such as lifestyle, socio-demography, cultural, and body composition, are associated with MetS. Limited research shows culturally tailored lifestyle interventions are effective in preventing and managing MetS and abdominal obesity among South Asians.
C1 [Jayawardena, Ranil] Univ Colombo, Fac Med, Dept Physiol, Colombo, Sri Lanka.
   [Jayawardena, Ranil; Sooriyaarachchi, Piumika] Queensland Univ Technol, Sch Exercise & Nutr Sci, Brisbane, Qld, Australia.
   [Misra, Anoop] Fortis C DOC Ctr Excellence Diabet Metab Dis & En, New Delhi, India.
C3 University of Colombo; Queensland University of Technology (QUT)
RP Jayawardena, R (corresponding author), Univ Colombo, Fac Med, Dept Physiol, Colombo, Sri Lanka.
EM ranil7@gmail.com
RI Jayawardena, Ranil/D-8693-2016; Sooriyaarachchi, Piumika/IUP-0422-2023
OI Sooriyaarachchi, Piumika/0000-0001-9570-2344
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NR 101
TC 24
Z9 26
U1 1
U2 17
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 1744-6651
EI 1744-8417
J9 EXPERT REV ENDOCRINO
JI Expert Rev. Endocrinol. Metab.
PD NOV 2
PY 2021
VL 16
IS 6
BP 339
EP 349
DI 10.1080/17446651.2021.1982381
EA OCT 2021
PG 11
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA XO2EW
UT WOS:000701499800001
PM 34586004
OA Green Published
DA 2025-06-11
ER

PT J
AU Keers, R
   Pedroso, I
   Breen, G
   Aitchison, KJ
   Nolan, PM
   Cichon, S
   Nöthen, MM
   Rietschel, M
   Schalkwyk, LC
   Fernandes, C
AF Keers, Robert
   Pedroso, Inti
   Breen, Gerome
   Aitchison, Kathy J.
   Nolan, Patrick M.
   Cichon, Sven
   Noethen, Markus M.
   Rietschel, Marcella
   Schalkwyk, Leonard C.
   Fernandes, Cathy
TI Reduced Anxiety and Depression-Like Behaviours in the Circadian Period
   Mutant Mouse Afterhours
SO PLOS ONE
LA English
DT Article
ID BIPOLAR-I-DISORDER; ERB-ALPHA-GENE; CLOCK GENES; METABOLIC SYNDROME;
   MOOD DISORDERS; ASSOCIATION; MODEL; DISRUPTION; FLUOXETINE; DESPAIR
AB Background: Disruption of the circadian rhythm is a key feature of bipolar disorder. Variation in genes encoding components of the molecular circadian clock has been associated with increased risk of the disorder in clinical populations. Similarly in animal models, disruption of the circadian clock can result in altered mood and anxiety which resemble features of human mania; including hyperactivity, reduced anxiety and reduced depression-like behaviour. One such mutant, after hours (Afh), an ENU-derived mutant with a mutation in a recently identified circadian clock gene Fbxl3, results in a disturbed (long) circadian rhythm of approximately 27 hours.
   Methodology: Anxiety, exploratory and depression-like behaviours were evaluated in Afh mice using the open-field, elevated plus maze, light-dark box, holeboard and forced swim test. To further validate findings for human mania, polymorphisms in the human homologue of FBXL3, genotyped by three genome wide case control studies, were tested for association with bipolar disorder.
   Principal Findings: Afh mice showed reduced anxiety- and depression-like behaviour in all of the behavioural tests employed, and some evidence of increased locomotor activity in some tests. An analysis of three separate human data sets revealed a gene wide association between variation in FBXL3 and bipolar disorder (P = 0.009).
   Conclusions: Our results are consistent with previous studies of mutants with extended circadian periods and suggest that disruption of FBXL3 is associated with mania-like behaviours in both mice and humans.
C1 [Keers, Robert; Pedroso, Inti; Breen, Gerome; Aitchison, Kathy J.; Schalkwyk, Leonard C.; Fernandes, Cathy] Kings Coll London, Inst Psychiat, MRC SGDP Ctr, London WC2R 2LS, England.
   [Nolan, Patrick M.] MRC Mammalian Genet Unit, Didcot, Oxon, England.
   [Cichon, Sven] Res Ctr Juelich, Struct & Funct Org Brain, INM 1, Julich, Germany.
   [Cichon, Sven; Noethen, Markus M.] Univ Bonn, Life & Brain Ctr, Dept Genom, Bonn, Germany.
   [Cichon, Sven; Noethen, Markus M.] Univ Bonn, Inst Human Genet, Bonn, Germany.
   [Rietschel, Marcella] Univ Mannheim, Cent Inst Mental Hlth, Dept Genet Epidemiol Psychiat, Mannheim, Germany.
C3 University of London; King's College London; Helmholtz Association;
   Research Center Julich; University of Bonn; University of Bonn;
   University of Mannheim; Central Institute of Mental Health
RP Keers, R (corresponding author), Kings Coll London, Inst Psychiat, MRC SGDP Ctr, London WC2R 2LS, England.
EM catherine.fernandes@kcl.ac.uk
RI Keers, Robert/C-1014-2009; Fernandes, Cathy/F-3422-2011; Kirsch,
   Peter/C-2499-2008; pedroso, inti/B-4989-2010; Nolan,
   Patrick/W-3918-2019; Schalkwyk, Leonard/A-2150-2010; Cichon,
   Sven/B-9618-2014; Aitchison, Katherine/G-4476-2013; Nothen,
   Markus/B-2027-2009; Breen, Gerome/A-5540-2010
OI Pedroso, Inti/0000-0002-5947-4556; Schalkwyk,
   Leonard/0000-0001-7030-5756; Fernandes, Cathy/0000-0001-7318-3352;
   Cichon, Sven/0000-0002-9475-086X; Aitchison,
   Katherine/0000-0002-1107-3024; Nolan, Patrick/0000-0001-5550-0334;
   Nothen, Markus/0000-0002-8770-2464; Breen, Gerome/0000-0003-2053-1792
FU MRC [MC_U142684173] Funding Source: UKRI
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NR 49
TC 46
Z9 59
U1 0
U2 14
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JUN 15
PY 2012
VL 7
IS 6
AR e38263
DI 10.1371/journal.pone.0038263
PG 10
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 959WX
UT WOS:000305350000012
PM 22719873
OA Green Accepted, Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Sagun, G
   Oguz, A
   Mesci, B
   Isbilen, B
   Kavala, M
   Keskin, H
   Takir, M
   Aydin, SZ
AF Sagun, Gul
   Oguz, Aytekin
   Mesci, Banu
   Isbilen, Banu
   Kavala, Mukaddes
   Keskin, Havva
   Takir, Mumtaz
   Aydin, Sibel Zehra
TI Levels of F2 isoprostane in Behcet's disease: Correlation
   with cardiometabolic risk factors
SO REDOX REPORT
LA English
DT Article
DE Behcet's disease; F-2 isoprostane; Cardiometabolic risk factors
ID CORONARY-ARTERY CALCIFICATION; SYSTEMIC-LUPUS-ERYTHEMATOSUS; OXIDATIVE
   STRESS; LIPID-PEROXIDATION; CARDIOVASCULAR-DISEASE; IN-VIVO;
   F-2-ISOPROSTANES; SCLERODERMA; F2-ALPHA; MARKERS
AB Objective: Behcet's disease (BD) is a chronic inflammatory disease and recent findings suggest a role of oxidative stress in the pathogenesis of BD. Free radical-induced oxidative stress is also involved in the pathogenesis of cardiovascular and other rheumatic diseases. Oxidative stress may be detected in vivo by measuring F-2 isoprostanes. Here, we measured plasma levels of F-2 isoprostane in patients with BD and evaluated the correlation of F-2 isoprostane with cardiometabolic risk factors.
   Methods: Forty-three patients with BD in remission and 37 age-and sex-matched controls were recruited for the study. Blood samples were obtained to determine F-2 isoprostane, C-reactive protein levels, erythrocyte sedimentation rate, and other biochemical parameters. Homeostasis model assessment insulin resistance and body mass index were calculated. Systolic blood pressure, diastolic blood pressure, and waist circumference were measured.
   Results: Plasma F-2 isoprostane, fasting plasma glucose, triglyceride, and C-reactive protein levels were significantly higher in patients with BD compared with healthy controls, whereas high-density lipoprotein cholesterol levels were significantly lower in patients with BD. F-2 isoprostane levels did not correlate with cardiometabolic risk factors, C-reactive protein levels, or erythrocyte sedimentation rate.
   Conclusion: High levels of F-2 isoprostane in patients with BD indicate oxidative stress. Antioxidant therapeutic approaches could potentially affect the course of this disease.
C1 [Sagun, Gul; Oguz, Aytekin; Mesci, Banu; Keskin, Havva; Takir, Mumtaz] Istanbul Medeniyet Univ Goztepe, Training & Res Hosp, Dept Internal Med, Istanbul, Turkey.
   [Isbilen, Banu] Istanbul Medeniyet Univ Goztepe, Training & Res Hosp, Dept Biochem, Istanbul, Turkey.
   [Kavala, Mukaddes] Istanbul Medeniyet Univ, Goztepe Training & Res Hosp, Dept Dermatol, Istanbul, Turkey.
   [Aydin, Sibel Zehra] Istanbul Medeniyet Univ, Goztepe Training & Res Hosp, Dept Rheumatol, Istanbul, Turkey.
C3 Istanbul Medeniyet University; Mehmet Akif Ersoy Thoracic Cardiovascular
   Surgery Education Research Hospital; Mehmet Akif Ersoy Thoracic
   Cardiovascular Surgery Education Research Hospital; Istanbul Medeniyet
   University; Istanbul Goztepe Training & Research Hospital; Istanbul
   Medeniyet University; Istanbul Goztepe Training & Research Hospital;
   Istanbul Medeniyet University
RP Sagun, G (corresponding author), Istanbul Medeniyet Univ Goztepe, Training & Res Hosp, Dept Internal Med, Istanbul, Turkey.
EM gulsagun@yahoo.com
RI Oguz, Aytekin/AAJ-2732-2021; Mesci, Banu/N-8081-2013; Basok,
   Banu/AEJ-9148-2022; Keskin, Havva/ABH-3101-2021
OI Basok, Banu Isbilen/0000-0002-1483-997X; MESCI, BANU/0000-0002-1524-2809
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NR 29
TC 3
Z9 3
U1 1
U2 20
PU MANEY PUBLISHING
PI LEEDS
PA STE 1C, JOSEPHS WELL, HANOVER WALK, LEEDS LS3 1AB, W YORKS, ENGLAND
SN 1351-0002
J9 REDOX REP
JI Redox Rep.
PD SEP
PY 2015
VL 20
IS 5
BP 223
EP 227
DI 10.1179/1351000215Y.0000000008
PG 5
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA CP6UX
UT WOS:000360024800005
PM 25867971
OA Green Published
DA 2025-06-11
ER

PT J
AU Kyrou, I
   Tsigos, C
AF Kyrou, I.
   Tsigos, C.
TI Stress mechanisms and-metabolic complications
SO HORMONE AND METABOLIC RESEARCH
LA English
DT Article; Proceedings Paper
CT Symposium on Cortisol Secretion Abnormalities
CY JUN, 2006
CL Bethesda, MD
SP NICHD
DE stress; glucocorticoids; cytokines; obesity; metabolic syndrome;
   inflammation; depression
ID PITUITARY-ADRENAL AXIS; RECOMBINANT HUMAN INTERLEUKIN-6;
   CORTICOTROPIN-RELEASING-FACTOR; INSULIN-RESISTANCE; DEPRESSIVE SYMPTOMS;
   HORMONE-SECRETION; VISCERAL OBESITY; ADIPOSE-TISSUE; NEUROENDOCRINE;
   INFLAMMATION
AB Stress can be defined as a state of threatened homeostasis or disharmony. An intricate repertoire of physiologic and behavioral responses is mobilized under stressful situations forming the adaptive stress response that aims to reestablish the challenged body equilibrium. The hypothalamic-pituitary-ad renal axis and the central and peripheral components of the autonomic nervous system constitute the two main pillars that subserve the vital functions of the stress system. Chronic stress represents a prolonged threat to homeostasis that can progressively lead to a deleterious overload with various complications caused by both the persistent stressor and the detrimental prolongation of the adaptive response. Recent data indicate that chronic stress is associated to derangement of metabolic homeostasis that contributes to the clinical presentation of visceral obesity, type 2 diabetes, atherosclerosis and metabolic syndrome. Notably, indices of stress in the modern western societies correlate with the increasing incidence of both obesity and the metabolic syndrome which have reached epidemic proportions over the past decades. The pathogenetic mechanisms that accommodate these correlations implicate primarily the chronic hyperactivation of the HPA axis under prolonged stress, which favors accumulation of visceral fat, and vice versa; obesity constitutes a chronic stressful state that may cause HPA axis dysfunction. In addition, obesity is being now recognized as a systemic low grade inflammatory state that contributes to the derangement of the metabolic equilibrium, implicating the adipocyte secretion of adipokines to the pathogenesis of several components of the metabolic syndrome. Understanding the mechanisms that mediate the documented reciprocal relationships between stress and metabolic homeostasis will hopefully provide novel insights to the pathophysiology of obesity, type 2 diabetes, and their cardiometabolic complications, and will help the quest for more specific and effective therapeutic interventions.
C1 Univ Athens, Evgenidion Hosp, Sch Med, Endocrinol Metab & Diabet Unit, Athens, Greece.
C3 National & Kapodistrian University of Athens; Athens Medical School
RP Tsigos, C (corresponding author), 82 Vas Sophias Ave, Athens 11528, Greece.
EM ctsigos@gmail.com
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NR 66
TC 105
Z9 127
U1 0
U2 15
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0018-5043
EI 1439-4286
J9 HORM METAB RES
JI Horm. Metab. Res.
PD JUN
PY 2007
VL 39
IS 6
BP 430
EP 438
DI 10.1055/s-2007-981462
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Endocrinology & Metabolism
GA 185SP
UT WOS:000247731000006
PM 17578760
DA 2025-06-11
ER

PT J
AU Mahdavi, M
   Ghaderi, A
   Hazegh, P
   Baseri, MHK
   Vahed, N
   Nazemi, S
   Aghajani, A
   Ghoreishi, FS
   Sadeghi-Gandomani, H
   Kashani, AT
AF Mahdavi, Mojtaba
   Ghaderi, Amir
   Hazegh, Pooya
   Baseri, Mohammad Hassan Karimipour
   Vahed, Neda
   Nazemi, Shekoofeh
   Aghajani, Ali
   Ghoreishi, Fatemeh Sadat
   Sadeghi-Gandomani, Hamidreza
   Kashani, Amene Taghdisi
TI Oral supplementation with crocin (a constituent of saffron) in subjects
   with cigarette smoking: a clinical trial
SO NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
LA English
DT Article
DE Cigarette smoking; Crocin; Nicotine dependence; Anxiety; Depression;
   Metabolic biomarkers
ID BECK DEPRESSION INVENTORY; SATIVUS L.; NICOTINE DEPENDENCE; OXIDATIVE
   DAMAGE; METAANALYSIS; DISORDER; MEDICINE; EXTRACT; INDEXES; SMOKERS
AB Smoking is one of the main causes of death in the world. Cigarette use is related with various components of metabolic syndrome (e.g., insulin resistance, raised blood pressure, dyslipidemia, oxidative stress, inflammation state) and psychiatric disorders. This study was conducted to determine the effect of crocin (Cro) supplementation on nicotine dependence, anxiety, depression, and metabolic indices in smokers. A total of 50 smokers were selected and randomly categorized into two groups (crocin and placebo). The intervention group received crocin (30 mg per day; n = 25) and placebo (containing Avicel; n = 25) once a day. The primary (nicotine dependence, depression, and anxiety inventory) and secondary (metabolic indices) outcomes were assessed at the start of the intervention and after the 3 months. Multiple linear regression models were used to assess the treatment effects on the outcomes adjusting for confounding variables. The primary outcome results such as nicotine dependence, depression, and anxiety inventory did not have a significant difference among the intervention groups (P > 0.05). Also in the secondary outcomes, fasting plasma glucose (FPG), insulin, and homeostasis model of assessment-insulin resistance (HOMA-IR) levels did indicate a significant difference by Cro intervention (beta - 3.27 mg/dL; 95% CI, - 5.23, - 1.31; P = 0.002; beta - 0.76 mu IU/mL; 95% CI, - 1.38, - 0.15; P = 0.01; beta - 0.18; 95% CI, - 0.29, - 0.07; P = 0.002), respectively. There were also significant reductions in serum levels of high-sensitivity C-reactive protein (hs-CRP) (beta - 0.72 mg/L; 95% CI, - 1.37, - 0.07; P = 0.03), compared with the placebo. Cro intake may have favorable effects on the level of FPG, insulin, HOMA-IR, and hs-CRP in smokers. However, due to the small sample size and limited scientific reports on smokers, further studies are necessary.
C1 [Mahdavi, Mojtaba; Ghaderi, Amir] Kashan Univ Med Sci, Sch Med, Dept Addict Studies, Kashan, Iran.
   [Ghaderi, Amir] Kashan Univ Med Sci, Kargarnejad Hosp, Clin Res Dev Unit Matini, Kashan, Iran.
   [Hazegh, Pooya; Ghoreishi, Fatemeh Sadat] Kashan Univ Med Sci, Dept Psychiat, Kashan, Iran.
   [Baseri, Mohammad Hassan Karimipour] Univ Tehran Med Sci, Sch Adv Technol Med, Dept Neurosci & Addict Studies, Tehran, Iran.
   [Vahed, Neda] Iran Univ Med Sci, Psychosocial Hlth Res Inst, Res Ctr Addict & Risky Behav ReCARB, Tehran, Iran.
   [Nazemi, Shekoofeh; Kashani, Amene Taghdisi] Kashan Univ Med Sci, Student Res Comm, Kashan, Iran.
   [Aghajani, Ali] Kashan Univ Med Sci, Fac Med, Dept Parasitol & Mycol, Kashan, Iran.
   [Sadeghi-Gandomani, Hamidreza] Shahrekord Univ Med Sci, Borujen Fac Nursing, Dept Nursing, Shahrekord, Iran.
   [Kashani, Amene Taghdisi] Kashan Univ Med Sci, Fac Dent, Dept Pediat, Kashan, Iran.
C3 Tehran University of Medical Sciences; Iran University of Medical
   Sciences; Shahrekord University Medical Sciences
RP Ghaderi, A (corresponding author), Kashan Univ Med Sci, Sch Med, Dept Addict Studies, Kashan, Iran.; Ghaderi, A (corresponding author), Kashan Univ Med Sci, Kargarnejad Hosp, Clin Res Dev Unit Matini, Kashan, Iran.; Kashani, AT (corresponding author), Kashan Univ Med Sci, Student Res Comm, Kashan, Iran.; Kashani, AT (corresponding author), Kashan Univ Med Sci, Fac Dent, Dept Pediat, Kashan, Iran.
EM mahdavi.mojtaba.tox@gmail.com; gaderiam@gmail.com;
   pooyahazegh@gmail.com; m.h.karimipor@gmail.com; Vahed.n@iums.ac.ir;
   shekoofenazemi9@gmail.com; aliaghajani44@yahoo.com;
   z.ghoreishi@yahoo.com; hamidsadegi1366@gmail.com; ataghdisi@yahoo.com
RI Ghoreishi, Fatemeh Sadat/HCH-9865-2022; Sadeghi-Gandomani,
   Hamidreza/AAZ-1667-2020
FU Research Deputy of Kashan University of Medical Sciences [400118]
FX The research grant was provided by the Research Deputy of Kashan
   University of Medical Sciences (ID: 400118).
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NR 75
TC 1
Z9 1
U1 2
U2 2
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0028-1298
EI 1432-1912
J9 N-S ARCH PHARMACOL
JI Naunyn-Schmiedebergs Arch. Pharmacol.
PD AUG
PY 2024
VL 397
IS 8
BP 5689
EP 5699
DI 10.1007/s00210-024-02970-7
EA JAN 2024
PG 11
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA C9U1P
UT WOS:001154431200002
PM 38294505
DA 2025-06-11
ER

PT J
AU Noroozi, S
   Karimi, M
   Farahani, AV
   Omidi, N
   Zargaran, A
   Soleymani, S
   Alaeddini, F
   Rezaeizadeh, H
AF Noroozi, Samaneh
   Karimi, Mehrdad
   Farahani, Ali Vasheghani
   Omidi, Negar
   Zargaran, Arman
   Soleymani, Samaneh
   Alaeddini, Farshid
   Rezaeizadeh, Hossein
TI Efficacy of Chamomile-Lemon Balm Syrup in Patients With Conventional
   Drug-Resistant Cardiac Syndrome X: A Single-Arm Clinical Trial
SO CRESCENT JOURNAL OF MEDICAL AND BIOLOGICAL SCIENCES
LA English
DT Article
DE Cardiac syndrome X; Matricaria chamomilla L; Melissa Officinalis L
ID CORONARY MICROVASCULAR DYSFUNCTION; PLACEBO-CONTROLLED TRIAL;
   MELISSA-OFFICINALIS L.; DOUBLE-BLIND; ENDOTHELIAL DYSFUNCTION; HEALTH
   SURVEY; ANGINA; INFLAMMATION; HEART; PATHOPHYSIOLOGY
AB Objectives: Treatment of cardiac syndrome X (CSX) remains a major challenge for conventional medicine. In this regard, developing new natural treatments could be an alternative choice. This study was planned to appraise the efficacy of chamomile-lemon balm syrup on chest pain and quality of life in patients with conventional drug-resistant CSX.Materials and Methods: 29 participants with conventional drug-resistant were enrolled in a single-arm clinical trial, and 14 participants completed the study protocol. Chamomile (Matricaria chamomilla L.)-lemon balm (Melissa officinalis L.) syrup was provided for the treatment for the 90-day study period. All conventional treatments of CSX remained unchanged. Efficacy assessment included Seattle Angina Questionnaires (SAQ), 36-item short form survey, and the Hospital Anxiety and Depression Scale (HADS).Results: An improvement was observed in the total score of all questionnaires with statistically significant changes over time of the study (P< 0.001).Conclusions: Chamomile-lemon balm syrup showed promising results in improving effect on angina symptoms, quality of life, and anxiety and depression in the patients with drug-resistant CSX. However, a placebo-controlled trial should be performed to verify these data.
C1 [Noroozi, Samaneh; Karimi, Mehrdad; Rezaeizadeh, Hossein] Univ Tehran Med Sci, Sch Persian Med, Dept Persian Med, Tehran, Iran.
   [Farahani, Ali Vasheghani; Omidi, Negar] Univ Tehran Med Sci, Cardiac Primary Prevent Res Ctr, Tehran Heart Ctr, Dept Cardiol, Tehran, Iran.
   [Zargaran, Arman; Soleymani, Samaneh] Univ Tehran Med Sci, Sch Persian Med, Dept Tradit Pharm, Tehran, Iran.
   [Alaeddini, Farshid] Red Crescent Soc Islamic Republ Iran, Res Ctr Hlth Management Mass Gathering, Tehran, Iran.
C3 Tehran University of Medical Sciences; Tehran University of Medical
   Sciences; Tehran University of Medical Sciences
RP Rezaeizadeh, H (corresponding author), Univ Tehran Med Sci, Sch Persian Med, Dept Persian Med, Tehran, Iran.
EM rezaeizadeh@sina.tums.ac.ir
RI Farahani, Ali/L-6076-2018; omidi, negar/AAE-6344-2021; Karimi,
   Mehrdad/JFS-5755-2023; Zargaran, Arman/G-9658-2011; Soleymani,
   Samaneh/AAX-8975-2021
FU school f Persian Medicine at Tehran University of Medical Sciences,
   Tehran, Iran [:191]
FX It is the results of Ph.D. thesis supported by the school f Persian
   Medicine at Tehran University of Medical Sciences, Tehran, Iran
   (number:191) . We are also indebted to the Tehran heart center and
   research development for their support.
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NR 52
TC 0
Z9 0
U1 0
U2 0
PU ARAS PART MEDICAL INT PRESS
PI TABRIZ
PA NO 1, S SHAREATI ST, 5138815941, TABRIZ, 00000, IRAN
SN 2148-9696
J9 CRESCENT J MED BIOL
JI Crescent J. Med. Biol. Sci.
PD APR
PY 2021
VL 10
IS 2
BP 73
EP 80
DI 10.34172/cjmb.2023.12
PG 8
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA C6FI1
UT WOS:000962848800004
OA Bronze
DA 2025-06-11
ER

PT J
AU Meydan, C
   Shenhar-Tsarfaty, S
   Soreq, H
AF Meydan, Chanan
   Shenhar-Tsarfaty, Shani
   Soreq, Hermona
TI MicroRNA Regulators of Anxiety and Metabolic Disorders
SO TRENDS IN MOLECULAR MEDICINE
LA English
DT Review
ID ACETYLCHOLINE-RECEPTOR ALPHA-7; MELANOCORTIN 4 RECEPTORS; SUBCUTANEOUS
   ADIPOSE; BEHAVIORAL VULNERABILITY; GENE-TRANSCRIPTION; EXPRESSION;
   OBESITY; NICOTINE; STRESS; ASSOCIATION
AB Anxiety-related and metabolic disorders are under intense research focus. Anxiety-induced microRNAs (miRNAs) are emerging as regulators that are not only capable of suppressing inflammation but can also induce metabolic syndrome-related processes. We summarize here evidence linking miRNA pathways which share regulatory networks in metabolic and anxiety-related conditions. In particular, miRNAs involved in these disorders include regulators of acetylcholine signaling in the nervous system and their accompanying molecular machinery. These have been associated with anxiety-prone states in individuals, while also acting as inflammatory suppressors. In peripheral tissues, altered miRNA pathways can lead to dysregulated metabolism. Common pathways in metabolic and anxiety-related phenomena might offer an opportunity to reclassify 'healthy' and 'unhealthy', as well as metabolic and anxiety-prone biological states, and inform putative strategies to treat these disorders.
C1 [Meydan, Chanan; Shenhar-Tsarfaty, Shani] Tel Aviv Sourasky Med Ctr, Dept Internal Med E, Tel Aviv, Israel.
   [Meydan, Chanan] Tel Aviv Univ, Sackler Sch Med, Tel Aviv, Israel.
   [Shenhar-Tsarfaty, Shani; Soreq, Hermona] Hebrew Univ Jerusalem, Edmond & Lily Safra Ctr Brain Sci, IL-91904 Jerusalem, Israel.
   [Shenhar-Tsarfaty, Shani; Soreq, Hermona] Hebrew Univ Jerusalem, Dept Biol Chem, IL-91904 Jerusalem, Israel.
C3 Tel Aviv University; Sackler Faculty of Medicine; Tel Aviv Sourasky
   Medical Center; Tel Aviv University; Sackler Faculty of Medicine; Hebrew
   University of Jerusalem; Hebrew University of Jerusalem
RP Soreq, H (corresponding author), Hebrew Univ Jerusalem, Edmond & Lily Safra Ctr Brain Sci, IL-91904 Jerusalem, Israel.; Soreq, H (corresponding author), Hebrew Univ Jerusalem, Dept Biol Chem, IL-91904 Jerusalem, Israel.
EM hermona.soreq@mail.huji.ac.il
RI Soreq, Hermona/AFM-0869-2022
OI Soreq, Hermona/0000-0002-0955-526X; Shenhar-Tsarfaty,
   Shani/0000-0002-8268-1799; Meydan, Chanan/0000-0002-8824-6309
FU European Research Council [321501]; Legacy Heritage Biomedical
   Partnership Program of the Israel Science Foundation [1799/10]; Israeli
   Ministry of Science; Eshkol post-doctoral fellowship; European Research
   Council (ERC) [321501] Funding Source: European Research Council (ERC)
FX The authors are indebted to Prof. S. Berliner (Tel Aviv Medical Center)
   and Ms P. Pollins and E. Banon (Jerusalem) for fruitful discussions,
   editing, and creative artwork. This study was supported by the European
   Research Council (Advanced Award 321501 to H.S.), the Legacy Heritage
   Biomedical Partnership Program of the Israel Science Foundation (grant
   1799/10, to H.S.), and The Israeli Ministry of Science, which awarded
   S.S-T. an Eshkol post-doctoral fellowship.
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NR 114
TC 34
Z9 35
U1 0
U2 13
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1471-4914
EI 1471-499X
J9 TRENDS MOL MED
JI Trends Mol. Med
PD SEP
PY 2016
VL 22
IS 9
BP 798
EP 812
DI 10.1016/j.molmed.2016.07.001
PG 15
WC Biochemistry & Molecular Biology; Cell Biology; Medicine, Research &
   Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology; Research & Experimental
   Medicine
GA DV0FP
UT WOS:000382593700008
PM 27496210
DA 2025-06-11
ER

PT J
AU Ballegaard, S
   Petersen, PB
   Harboe, GS
   Karpatschof, B
   Gyntelberg, F
   Faber, J
AF Ballegaard, Soren
   Petersen, Pernille B.
   Harboe, Gitte S.
   Karpatschof, Benny
   Gyntelberg, Finn
   Faber, Jens
TI The association between changes in pressure pain sensitivity and changes
   in cardiovascular physiological factors associated with persistent
   stress
SO SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION
LA English
DT Article
DE Stress; pressure pain threshold; blood pressure; heart rate;
   pressure-rate-product; BMI; cholesterol
ID CORONARY-ARTERY-DISEASE; INTEGRATED REHABILITATION; PSYCHOLOGICAL
   STRESS; METABOLIC SYNDROME; ANGINA-PECTORIS; MENTAL STRESS; HEALTH;
   ALLOSTASIS; DYSFUNCTION; MODULATION
AB Objectives. To evaluate the possible association between pressure pain sensitivity of the chest bone (PPS) and cardiovascular physiological factors related to persistent stress in connection with a three-month PPS-guided stress-reducing experimental intervention programme. Methods. Forty-two office workers with an elevated PPS (> 60 arbitrary units) as a sign of increased level of persistent stress, completed a single-blinded cluster randomized controlled trial. The active treatment was a PPS (self-measurement)-guided stress management programme. Primary endpoints: Blood pressure (BP), heart rate (HR) and work of the heart measured as Pressure-Rate-Product (PRP); Secondary endpoints: Other features of the metabolic syndrome. Results. PPS decreased and changes in PPS after the intervention period were significantly associated with HR, PRP, body mass index (BMI) and visceral fat index (all correlation coefficients >0.2, p < 0.05). Compared to the control cluster group, the active cluster group obtained a significant reduction in PPS, Low-density lipoprotein (LDL) cholesterol and total number of elevated risk factors (p < 0.05). On an individual level, significant and clinically relevant between-group reductions were observed in respect to BP, HR, PRP, total and LDL cholesterol, and total number of elevated risk factors (p < 0.05). Conclusions. The stress intervention method applied in this study induced a decrease in PPS which was associated with a clinically relevant decrease in resting blood pressure, heart rate, work of the heart and serum cholesterols.
C1 [Ballegaard, Soren; Petersen, Pernille B.; Harboe, Gitte S.] Ull Care, Hellerup, Denmark.
   [Gyntelberg, Finn] Natl Res Ctr Working Environm, Copenhagen, Denmark.
   [Faber, Jens] Univ Copenhagen, Herlev Univ Hosp, Dept Med & Endocrinol O, Herlev, Denmark.
   [Karpatschof, Benny] Univ Copenhagen, Dept Psychol, Herlev, Denmark.
   [Faber, Jens] Univ Copenhagen, Fac Hlth Sci, Herlev, Denmark.
C3 National Research Centre for the Working Environment; University of
   Copenhagen; University of Copenhagen
RP Ballegaard, S (corresponding author), Lemchesvej 1, DK-2900 Hellerup, Denmark.
EM sba@ullcare.com
FU Willis Ltd
FX In the pilot study, we wish to thank Anne Margrethe Dahl, the Royal
   Danish Opera Academy for conducting all instructions and contacts to the
   students in the active group as well as for allocation of study for the
   active group. We wish to thank Eva Hess Thaysen, The Royal Danish
   Academy of Music, for help with conducting and allocating the study for
   the control group. We wish to thank Charlotte Christiansen for help with
   carrying out the study in office workers. The lab technicians from
   Department of Endocrinology 54O4, Herlev University Hospital are thanked
   for their skillful job concerning blood sampling and measurements. We
   wish to thank the insurance broker Willis Ltd for an unrestricted
   financial funding. For statistical analysis with regard to Cluster
   Randomization design we thank Bjarne Ersboell, Department of Applied
   Mathematics and Computer Science, Technical University of Denmark.
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NR 43
TC 10
Z9 11
U1 0
U2 7
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0036-5513
EI 1502-7686
J9 SCAND J CLIN LAB INV
JI Scand. J. Clin. Lab. Invest.
PD MAR
PY 2014
VL 74
IS 2
BP 116
EP 125
DI 10.3109/00365513.2013.862847
PG 10
WC Medical Laboratory Technology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology; Research & Experimental Medicine
GA AF5EV
UT WOS:000334737700006
PM 24313546
DA 2025-06-11
ER

PT J
AU Serra, MC
   Goldberg, AP
   Ryan, AS
AF Serra, Monica C.
   Goldberg, Andrew P.
   Ryan, Alice S.
TI Increased depression and metabolic risk in postmenopausal breast cancer
   survivors
SO DIABETOLOGY & METABOLIC SYNDROME
LA English
DT Article
ID QUALITY-OF-LIFE; WEIGHT CHANGE; EXERCISE; DIAGNOSIS; SYMPTOMS; WOMEN;
   INFLAMMATION; POPULATION; PREVALENCE; STATISTICS
AB Objective: Breast cancer survivors (BCS) are at high risk for the development of obesity, type 2 diabetes mellitus, and metabolic syndrome. There is increasing interest in the association between depression and metabolic dysfunction, which is relevant in this population as depression is often present in the chronic phase of cancer recovery. Thus, the aim of this study was to evaluate metabolic risk in BCS with and without depression compared to non-cancer controls.
   Methods: African American (46 %) and Caucasian (54 %) postmenopausal BCS (N = 28; age: 60 +/- 2 years; mean +/- SEM) were matched for race, age (+/- 2 years), and BMI (+/- 2 kg/m(2)) to non-cancer controls (N = 28). Center for Epidemiologic Studies Depression Scale (CES-D) > 16 or antidepressant medication usage was used to classify depression. Metabolic status was defined by 2-hr glucose during an OGTT and classification of metabolic syndrome.
   Results: Compared to non-cancer controls, BCS had similar 2-hr glucose, but higher fasting glucose and total cholesterol, and were 2.5 times more likely to have metabolic syndrome (21 vs. 52 %)(P's < 0.05). Conversely, HDL-C was 16 % higher in BCS (P < 0.05). Forty three % of BCS were on antidepressants compared to 14 % in non-cancer controls, despite similar mean CES-D scores (6 +/- 1). Depressed BCS (46 %) had a higher BMI, waist circumference, fasting glucose, and more metabolic syndrome components than non-depressed BCS (P's < 0.05).
   Conclusions: BCS have a heightened prevalence of depression that may be associated with an increased prevalence of metabolic syndrome. These results support the need to monitor weight gain, depression, and the progression of metabolic abnormalities after cancer diagnosis and treatment. Further studies into the mechanistic link between depression and metabolic disease are necessary to identify strategies that can offset their impact on obesity and associated cardiovascular risk following a breast cancer diagnosis.
C1 [Serra, Monica C.] Univ Maryland, Sch Med, Dept Med, Div Gerontol & Geriatr Med, 10 N Greene St,BT-18-GR, Baltimore, MD 21201 USA.
   Baltimore VA Med Ctr, Geriatr Res & Educ Clin Ctr, 10 N Greene St,BT-18-GR, Baltimore, MD 21201 USA.
C3 University System of Maryland; University of Maryland Baltimore;
   Geriatric Research Education & Clinical Center; US Department of
   Veterans Affairs; Veterans Health Administration (VHA); Baltimore VA
   Medical Center
RP Serra, MC (corresponding author), Univ Maryland, Sch Med, Dept Med, Div Gerontol & Geriatr Med, 10 N Greene St,BT-18-GR, Baltimore, MD 21201 USA.
EM mserra@grecc.umaryland.edu
FU National Institute on Aging (NIA) [R01-AG19310, R01-AG20116]; Maryland
   Claude D. Pepper Older Americans Independence Center [P30 AG028747];
   NIDDK Mid-Atlantic Nutrition Obesity Research Center [NIH P30 DK072488];
   Department of Veterans Affairs and Veterans Affairs Medical Center
   Baltimore Geriatric Research, Education and Clinical Center (GRECC); VA
   Senior Research Career Scientist Award; VA Career Development Award; 
   [5T32AG000219-18]
FX Our appreciation is extended to the women who participated in this
   study. We are grateful to the nurses and exercise physiologists of the
   University of Maryland School of Medicine, Division of Gerontology and
   Geriatric Medicine and Baltimore VA GRECC for their assistance in this
   project. This study was supported by funds from: National Institute on
   Aging (NIA) Grants: R01-AG19310, R01-AG20116, Maryland Claude D. Pepper
   Older Americans Independence Center (P30 AG028747), and 5T32AG000219-18;
   NIDDK Mid-Atlantic Nutrition Obesity Research Center (NIH P30 DK072488);
   Department of Veterans Affairs and Veterans Affairs Medical Center
   Baltimore Geriatric Research, Education and Clinical Center (GRECC); a
   VA Senior Research Career Scientist Award to ASR and a VA Career
   Development Award to MCS.
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NR 51
TC 10
Z9 11
U1 0
U2 23
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1758-5996
J9 DIABETOL METAB SYNDR
JI Diabetol. Metab. Syndr.
PD JUL 22
PY 2016
VL 8
AR 44
DI 10.1186/s13098-016-0170-4
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA DR8LF
UT WOS:000380148700004
PM 27453736
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Hajializadeh, Z
   Khaksari, M
   Najafipour, H
   Sanjari, M
   Mahani, FD
   Raji-Amirhasani, A
AF Hajializadeh, Zahra
   Khaksari, Mohammad
   Najafipour, Hamid
   Sanjari, Mojgan
   Mahani, Fatemeh Darvishzadeh
   Raji-Amirhasani, Alireza
TI Substitution of calorie restriction for protective effects of estrogen
   on cardiometabolic risk factors and oxidative stress in obese
   postmenopausal rat model
SO LIFE SCIENCES
LA English
DT Article
DE Obesity; Calorie restriction; High fat diet; High 17-beta estradiol;
   Postmenopausal rat; Oxidative stress
ID ENERGY-EXPENDITURE; BODY-COMPOSITION; DIET; FAT; MENOPAUSE; EXERCISE;
   RECEPTOR; WEIGHT; INFLAMMATION; DYSFUNCTION
AB Estrogen has an anti-obesity effect and plays an important role in improving cardiometabolic disorders. Weight loss and reduction in calorie intake impede the development of obesity-related cardiometabolic risk factors. Therefore, we investigated the substitution of calorie restriction for effects of estrogen on cardiometabolic risk factors and oxidative stress in obese postmenopausal rat model.In this study, adult female Wistar rats were allocated into Sham and ovariectomized (OVX) groups and were given standard diet (SD) or 60% high-fat diet (HFD) or 30% calorie restriction (CR) for 16 weeks, following this, animals received E2 (17-beta estradiol; 1 mg/kg; i.p.) every four days for 4 weeks.Results showed that HFD elevated the body weight, BMI, food intake, and blood glucose (BG) level in both sham and OVX groups. In addition, HFD had negative effects on lipid profile and oxidative stress in these groups. Whereas CR decreased these indices in both Sham and OVX groups fed an HFD, it could not diminish the BG level in the OVX-HFD group. E2 treatment in OVX animals with or without CR reduced body weight, BMI, food intake, and BG level, and also had positive effects on lipid profile alterations and oxidative stress reduction. In comparison, no significant differences were observed regarding the effects of E2 with CR between two groups for body weight, lipid profile, BG, and oxidative stress in the OVX-HFD rats.Overall, CR prevents and ameliorates cardiometabolic risk factors induced by obesity in postmenopausal conditions and is also a good candidate for E2 substitution.
C1 [Hajializadeh, Zahra] Kerman Univ Med Sci, Physiol Res Ctr, Inst Neuropharmacol, Kerman, Iran.
   [Khaksari, Mohammad; Sanjari, Mojgan; Mahani, Fatemeh Darvishzadeh] Kerman Univ Med Sci Kerman, Endocrinol & Metab Res Ctr, Inst Basic & Clin Physiol Sci, Kerman, Iran.
   [Najafipour, Hamid] Kerman Univ Med Sci, Afzalipour Fac Med, Cardiovasc Res Ctr, Inst Basic & Clin Physiol Sci,Dept Physiol & Phar, Kerman, Iran.
   [Raji-Amirhasani, Alireza] Kerman Univ Med Sci, Afzalipour Fac Med, Gastroenterol & Hepatol Res Ctr, Inst Basic & Clin Physiol Sci,Dept Physiol & Phar, Kerman, Iran.
C3 Kerman University of Medical Sciences; Kerman University of Medical
   Sciences; Kerman University of Medical Sciences
RP Khaksari, M (corresponding author), Endocrinol & Metab Res Ctr, 22 Bahman Blvd, Kerman, Iran.; Khaksari, M (corresponding author), Dept Physiol & Pharmacol, 22 Bahman Blvd, Kerman, Iran.
EM mkhaksari@kmu.ac.ir
RI Najafipour, Hamid/U-7922-2017; Raji-Amirhasani, Alireza/GLU-7149-2022;
   Haddad, Mohammad/AAB-9025-2019; Darvishzadeh Mahani,
   Fatemeh/JXN-2593-2024
OI Khaksari, Mohammad/0000-0003-0770-4281; Raji-Amirhasani,
   Alireza/0000-0002-0693-5048; Najafipour, Hamid/0000-0002-8030-8704;
   Sanjari, Mojgan/0000-0002-3402-4401; Darvishzadeh-Mahani,
   Fatemeh/0000-0002-4006-1823
FU Kerman University of Medical Sci-ences [99000202]
FX Funding This work was supported by the Kerman University of Medical
   Sci-ences [grant number 99000202] .
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NR 45
TC 9
Z9 10
U1 0
U2 1
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0024-3205
EI 1879-0631
J9 LIFE SCI
JI Life Sci.
PD APR 1
PY 2022
VL 294
AR 120367
DI 10.1016/j.lfs.2022.120367
EA FEB 2022
PG 12
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA 0G1HX
UT WOS:000777804900004
PM 35104476
DA 2025-06-11
ER

PT J
AU Ringen, PA
   Falk, RS
   Antonsen, B
   Faerden, A
   Mamen, A
   Rognli, EB
   Solberg, DK
   Martinsen, EW
   Andreassen, OA
AF Ringen, Petter Andreas
   Falk, Ragnhild S.
   Antonsen, Bjornar
   Faerden, Ann
   Mamen, Asgeir
   Rognli, Eline B.
   Solberg, Dag K.
   Martinsen, Egil W.
   Andreassen, Ole A.
TI Using motivational techniques to reduce cardiometabolic risk factors in
   long term psychiatric inpatients: a naturalistic interventional study
SO BMC PSYCHIATRY
LA English
DT Article
DE Cardiometabolic; Cardiovascular; Motivation; Intervention; Lifestyle;
   Psychosis; Schizophrenia; Inpatient; Physical activity
ID REPORTED PHYSICAL-ACTIVITY; NORD-TRONDELAG HEALTH; ALL-CAUSE MORTALITY;
   MENTAL-ILLNESS; WEIGHT-LOSS; CARDIOVASCULAR-DISEASE; SCHIZOPHRENIA;
   EXERCISE; PEOPLE; RELIABILITY
AB Background: People with severe mental illness have markedly reduced life expectancy; cardiometabolic disease is a major cause. Psychiatric hospital inpatients have elevated levels of cardiometabolic risk factors and are to a high degree dependent of the routines and facilities of the institutions. Studies of lifestyle interventions to reduce cardiometabolic risk in psychiatric inpatients are few. The current study aimed at assessing the feasibility and effects of a lifestyle intervention including Motivational Interviewing (MI) on physical activity levels, cardiometabolic risk status and mental health status in psychotic disorder inpatients.
   Methods: Prospective naturalistic intervention study of 83 patients at long term inpatient psychosis treatment wards in South-Eastern Norway. Patients were assessed 3-6 months prior to, at start and 6 months after a life-style intervention program including training of staff in MI, simple changes in routines and improvements of facilities for physical exercise. Assessments were done by clinical staff and included level of physical activity, motivation, life satisfaction, symptom levels (MADRS, AES-C, PANSS, and GAF) as well as anthropometric and biochemical markers of cardiometabolic risk A mixed model was applied to analyze change over time.
   Results: A total of 88% of patients received MI interventions, with a mean of 2.5 MI interventions per week per patient The physical activity level was not increased, but activity level was positively associated with motivation and negatively associated with positive symptoms. Triglyceride levels and number of smokers were significantly reduced and a significant decrease in symptom levels was observed.
   Conclusions: The current results suggest that a simple, low cost life-style intervention program focusing on motivational change is feasible and may reduce symptoms and improve lifestyle habits in psychosis patients in long term treatment facilities. Similar programs may easily be implemented in other psychiatric hospitals.
C1 [Ringen, Petter Andreas; Faerden, Ann] Oslo Univ Hosp, Div Mental Hlth & Addict, POB 4956, N-0424 Oslo, Norway.
   [Ringen, Petter Andreas; Faerden, Ann] Univ Oslo, Ulleval Hosp, KG Jebsen Ctr, NORMENT, POB 4956, N-0424 Oslo, Norway.
   [Falk, Ragnhild S.] Oslo Univ Hosp, Oslo Ctr Biostat & Epidemiol, POB 4950, N-0424 Oslo, Norway.
   [Antonsen, Bjornar] Lovisenberg Diaconal Hosp, Dept Psychiat, POB 4970, N-0440 Oslo, Norway.
   [Mamen, Asgeir] Kristiania Univ Coll, POB 1190, N-0107 Oslo, Norway.
   [Rognli, Eline B.] Oslo Univ Hosp, Ulleval Hosp, Div Mental Hlth & Addict, POB 4956, N-0424 Oslo, Norway.
   [Solberg, Dag K.] Diakonhjemmet Hosp, Lukas Fdn, Skjelfoss Psychiat Ctr, Postboks 23, N-0319 Oslo, Norway.
   [Solberg, Dag K.] Diakonhjemmet Hosp, Ctr Psychopharmacol, Postboks 23, N-0319 Oslo, Norway.
   [Martinsen, Egil W.] Oslo Univ Hosp, Div Mental Hlth & Addict, POB 4956, N-0424 Oslo, Norway.
   [Martinsen, Egil W.; Andreassen, Ole A.] Univ Oslo, Ulleval Hosp, POB 4956, N-0424 Oslo, Norway.
   [Andreassen, Ole A.] Oslo Univ Hosp, KG Jebsen Ctr, NORMENT, Bldg 49,POB 4956, N-0424 Oslo, Norway.
C3 University of Oslo; University of Oslo; University of Oslo; Kristiania
   University College; University of Oslo; Diakonhjemmet Hospital;
   Diakonhjemmet Hospital; University of Oslo; University of Oslo;
   University of Oslo
RP Ringen, PA (corresponding author), Oslo Univ Hosp, Div Mental Hlth & Addict, POB 4956, N-0424 Oslo, Norway.; Ringen, PA (corresponding author), Univ Oslo, Ulleval Hosp, KG Jebsen Ctr, NORMENT, POB 4956, N-0424 Oslo, Norway.
EM p.a.ringen@medisin.uio.no
RI ringen, petter/C-5036-2011; Rognli, Eline/MDT-0030-2025; Andreassen,
   Ole/AAY-7531-2020; Mamen, Asgeir/N-9572-2019; Falk, Ragnhild/H-5613-2019
OI Falk, Ragnhild/0000-0001-8398-3492; Rognli, Eline/0000-0002-7248-3019
FU Research Council of Norway [223273]; Division of Mental Health and
   Addiction, Oslo University Hospital; Skjelfoss Psychiatric Center
FX This work was supported by the Research Council of Norway under Grant
   223273. The Research Council of Norway had no role in the design of the
   study or in the collection, analysis, or interpretation of data or in
   writing the manuscript. The study received funding and resources from
   the Division of Mental Health and Addiction, Oslo University Hospital,
   and from the Skjelfoss Psychiatric Center. The study were led and
   carried out by employees of these institutions.
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NR 47
TC 9
Z9 9
U1 0
U2 9
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-244X
J9 BMC PSYCHIATRY
JI BMC Psychiatry
PD AUG 15
PY 2018
VL 18
AR 255
DI 10.1186/s12888-018-1832-6
PG 9
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA GQ6RH
UT WOS:000441850700002
PM 30111298
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Herr, DR
   Chew, WS
   Satish, RL
   Ong, WY
AF Herr, Deron R.
   Chew, Wee Siong
   Satish, R. L.
   Ong, Wei-Yi
TI Pleotropic Roles of Autotaxin in the Nervous System Present
   Opportunities for the Development of Novel Therapeutics for Neurological
   Diseases
SO MOLECULAR NEUROBIOLOGY
LA English
DT Article
DE Autotaxin; Lysophospholipase D; Inflammatory neuropathic pain;
   Glioblastoma multiforme; Hemorrhagic hydrocephalus; Schizophrenia;
   Multiple sclerosis; Alzheimer's disease; Metabolic syndrome-induced
   brain damage; Traumatic brain injury; Hepatic encephalopathy induced
   cerebral edema; Macular edema; Major depressive disorder; Stress-induced
   psychiatric disorder; Alcohol-induced brain damage; HIV-induced brain
   injury; Pruritus; Peripheral nerve injury
ID LYSOPHOSPHATIDIC ACID RECEPTOR; OBVIOUS PHENOTYPIC ABNORMALITY;
   PROTEIN-COUPLED RECEPTOR; NF-KAPPA-B; LYSOPHOSPHOLIPASE-D;
   CEREBROSPINAL-FLUID; ALZHEIMERS-DISEASE; I-ALPHA/AUTOTAXIN; NEUROPATHIC
   PAIN; PHARMACOLOGICAL CHARACTERIZATION
AB Autotaxin (ATX) is a soluble extracellular enzyme that is abundant in mammalian plasma and cerebrospinal fluid (CSF). It has two known enzymatic activities, acting as both a phosphodiesterase and a phospholipase. The majority of its biological effects have been associated with its ability to liberate lysophosphatidic acid (LPA) from its substrate, lysophosphatidylcholine (LPC). LPA has diverse pleiotropic effects in the central nervous system (CNS) and other tissues via the activation of a family of six cognate G protein-coupled receptors. These LPA receptors (LPARs) are expressed in some combination in all known cell types in the CNS where they mediate such fundamental cellular processes as proliferation, differentiation, migration, chronic inflammation, and cytoskeletal organization. As a result, dysregulation of LPA content may contribute to many CNS and PNS disorders such as chronic inflammatory or neuropathic pain, glioblastoma multiforme (GBM), hemorrhagic hydrocephalus, schizophrenia, multiple sclerosis, Alzheimer's disease, metabolic syndrome-induced brain damage, traumatic brain injury, hepatic encephalopathy-induced cerebral edema, macular edema, major depressive disorder, stress-induced psychiatric disorder, alcohol-induced brain damage, HIV-induced brain injury, pruritus, and peripheral nerve injury. ATX activity is now known to be the primary biological source of this bioactive signaling lipid, and as such, represents a potentially high-value drug target. There is currently one ATX inhibitor entering phase III clinical trials, with several additional preclinical compounds under investigation. This review discusses the physiological and pathological significance of the ATX-LPA-LPA receptor signaling axis and summarizes the evidence for targeting this pathway for the treatment of CNS diseases.
C1 [Herr, Deron R.; Chew, Wee Siong] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Pharmacol, Singapore 117600, Singapore.
   [Herr, Deron R.] San Diego State Univ, Dept Biol, San Diego, CA 92182 USA.
   [Satish, R. L.; Ong, Wei-Yi] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Anat, Singapore 119260, Singapore.
   [Ong, Wei-Yi] Natl Univ Singapore, Inst Life Sci, Neurobiol Programme, Singapore 119260, Singapore.
C3 National University of Singapore; California State University System;
   San Diego State University; National University of Singapore; National
   University of Singapore
RP Herr, DR (corresponding author), Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Pharmacol, Singapore 117600, Singapore.; Herr, DR (corresponding author), San Diego State Univ, Dept Biol, San Diego, CA 92182 USA.; Ong, WY (corresponding author), Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Anat, Singapore 119260, Singapore.; Ong, WY (corresponding author), Natl Univ Singapore, Inst Life Sci, Neurobiol Programme, Singapore 119260, Singapore.
EM phcdrh@nus.edu.sg; wei_yi_ong@nuhs.edu.eg
RI Herr, Deron/AAB-7380-2020
OI Lakshminarasappa, Satish/0000-0002-1454-3503; Ong,
   Wei-Yi/0000-0001-9756-7772
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NR 189
TC 36
Z9 37
U1 0
U2 15
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0893-7648
EI 1559-1182
J9 MOL NEUROBIOL
JI Mol. Neurobiol.
PD JAN
PY 2020
VL 57
IS 1
SI SI
BP 372
EP 392
DI 10.1007/s12035-019-01719-1
PG 21
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA KV1HZ
UT WOS:000520176200033
PM 31364025
DA 2025-06-11
ER

PT J
AU Prather, AA
   Vogelzangs, N
   Penninx, BWJH
AF Prather, Aric A.
   Vogelzangs, Nicole
   Penninx, Brenda W. J. H.
TI Sleep duration, insomnia, and markers of systemic inflammation: Results
   from the Netherlands Study of Depression and Anxiety (NESDA)
SO JOURNAL OF PSYCHIATRIC RESEARCH
LA English
DT Article
DE Sleep duration; Inflammation; Depression; Anxiety; Insomnia
ID C-REACTIVE PROTEIN; MAJOR DEPRESSION; LONG SLEEPERS; WOMENS HEALTH;
   CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; IMMUNE-SYSTEM; RATING-SCALE;
   DISORDERS; RISK
AB Systemic inflammation has emerged as a potential pathway linking depressive and anxiety disorders with disease risk. Short and long sleep duration, as well as insomnia, are common among psychiatric populations and have previously been related to increased inflammation. The aim of the present study was to investigate associations between sleep duration and insomnia with biomarkers of inflammation and to explore whether these associations varied by psychiatric diagnostic status. To this end, self-reported measures of sleep duration, insomnia symptoms, and markers of inflammation, including C-reactive protein (CRP), interleukin-(IL)-6, and tumor necrosis factor (TNF)-alpha, were obtained in 2553 adults (aged 18-65 years) diagnosed with current/recent or remitted depressive and/or anxiety disorders and healthy controls enrolled in the Netherlands Study of Depression and Anxiety (NESDA). Regression analyses revealed associations between sleep duration and levels of CRP and IL-6 with higher levels observed in long sleepers. These associations remained statistically significant after controlling for age, gender, education, body mass index, smoking, alcohol consumption, medical comorbidities, medication use, psychotropic medication use, and psychiatric diagnostic status. There were no clear associations between insomnia symptoms and levels of inflammation. Relationships between sleep duration and inflammation did not vary as a function of psychiatric diagnostic status. These findings suggest that elevated levels of systemic inflammation may represent a mechanism linking long sleep duration and disease risk among those with and without depressive and anxiety disorders. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Prather, Aric A.] Univ Calif San Francisco, Dept Psychiat, San Francisco, CA 94118 USA.
   [Vogelzangs, Nicole; Penninx, Brenda W. J. H.] Vrije Univ Amsterdam Med Ctr, Dept Psychiat, EMGO Inst Hlth & Care Res, Amsterdam, Netherlands.
C3 University of California System; University of California San Francisco;
   Vrije Universiteit Amsterdam; VU UNIVERSITY MEDICAL CENTER
RP Prather, AA (corresponding author), Univ Calif San Francisco, Dept Psychiat, 3333 Calif St,Suite 465, San Francisco, CA 94118 USA.
EM aric.prather@ucsf.edu
RI Penninx, Brenda/S-7627-2017
OI Prather, Aric/0000-0003-1302-8283
FU NIH/NHLBI [K08HL112961]; Geestkracht program of the Netherlands
   Organisation for Health Research and Development (Zon-Mw) [10-000-1002];
   VU University Medical Center, GGZ inGeest, Arkin; Leiden University
   Medical Center, GGZ Rivierduinen; University Medical Center Groningen,
   Lentis; GGZ Friesland; GGZ Drenthe; Institute for Quality of Health Care
   (IQ Healthcare); Netherlands Institute for Health Services Research
   (NIVEL); Netherlands Institute of Mental Health and Addiction (Trimbos);
   NWO-VICI [91811602]; Neuroscience Campus Amsterdam
FX This research was supported in part by a NIH/NHLBI Grant K08HL112961 to
   Dr. Prather. The infrastructure for the NESDA study (www.nesda.nl) is
   funded through the Geestkracht program of the Netherlands Organisation
   for Health Research and Development (Zon-Mw, grant number 10-000-1002)
   and is supported by participating universities and mental health care
   organizations (VU University Medical Center, GGZ inGeest, Arkin, Leiden
   University Medical Center, GGZ Rivierduinen, University Medical Center
   Groningen, Lentis, GGZ Friesland, GGZ Drenthe, Institute for Quality of
   Health Care (IQ Healthcare), Netherlands Institute for Health Services
   Research (NIVEL) and Netherlands Institute of Mental Health and
   Addiction (Trimbos)). BP was supported through a NWO-VICI grant (number
   91811602). Assaying of inflammatory markers was supported by the
   Neuroscience Campus Amsterdam.
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NR 56
TC 104
Z9 115
U1 0
U2 55
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-3956
EI 1879-1379
J9 J PSYCHIATR RES
JI J. Psychiatr. Res.
PD JAN
PY 2015
VL 60
BP 95
EP 102
DI 10.1016/j.jpsychires.2014.09.018
PG 8
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA AY0DR
UT WOS:000347268500012
PM 25307717
OA Green Published, Green Accepted
DA 2025-06-11
ER

PT J
AU Lim, TK
   Choy, AJ
   Khan, F
   Belch, JJ
   Struthers, AD
   Lang, CC
AF Lim, Tiong K.
   Choy, AnnaMaria J.
   Khan, Faisel
   Belch, Jill J. F.
   Struthers, Allan D.
   Lang, Chim C.
TI Therapeutic Development in Cardiac Syndrome X: A Need to Target the
   Underlying Pathophysiology
SO CARDIOVASCULAR THERAPEUTICS
LA English
DT Review
DE Cardiac syndrome X; Chest pain; Endothelial dysfunction; Microvascular
   dysfunction; Normal coronary angiogram
ID NORMAL CORONARY ANGIOGRAMS; CARDIOVASCULAR MAGNETIC-RESONANCE; IMPROVES
   ENDOTHELIAL FUNCTION; CONVERTING ENZYME-INHIBITION; XANTHINE-OXIDASE
   INHIBITORS; EXERCISE-INDUCED ANGINA; ST SEGMENT DEPRESSION; LONG-TERM
   PROGNOSIS; C-REACTIVE PROTEIN; CHEST-PAIN
AB Morbidity of patients with cardiac syndrome X (typical anginal-like chest pain and normal coronary arteriogram) is high with continuing episodes of chest pain and frequent hospital readmissions. Management of this syndrome represents a major challenge for the treating physician. Conventional therapies with antianginal agents such as nitrates, calcium channel antagonists, classic beta-adrenoceptor blockers and nicorandil have been tried, with variable success. However, this might be related to a failure to target the underlying pathophysiology and, clearly, more effective therapies are needed. Supporting evidence for the important role of endothelial dysfunction and oxidative stress in the pathogenesis of cardiac syndrome X has come from the recent observation that basal superoxide production predicts future cardiovascular events in this patient group. This review will discuss the pathophysiology, current medical management and potential new pharmacological treatment for patients with cardiac syndrome X which target endothelial dysfunction and oxidative stress.
   What's already known about this topic ?
   center dot Morbidity of patients with cardiac syndrome X is high.
   center dot The important role of endothelial dysfunction and oxidative stress in the pathogenesis of cardiac syndrome X.
   What does this article add ?
   center dot This review will discuss the pathophysiology, current medical management and potential new pharmacological treatment for patients with cardiac syndrome X which target endothelial dysfunction and oxidative stress.
C1 [Lim, Tiong K.; Choy, AnnaMaria J.; Khan, Faisel; Belch, Jill J. F.; Struthers, Allan D.; Lang, Chim C.] Univ Dundee, Div Med & Therapeut, Dundee DD1 9SY, Scotland.
C3 University of Dundee
RP Lang, CC (corresponding author), Univ Dundee, Ninewells Hosp & Med Sch, Div Med & Therapeut, Dundee DD1 9SY, Scotland.
EM c.c.lang@dundee.ac.uk
RI Choy, AnnaMaria/MZR-9039-2025; Lang, Chim/JFJ-8074-2023; Belch, Jill
   JF/AAE-9189-2019
OI Lang, Chim/0000-0002-4530-3078; Choy, Anna Maria/0000-0002-4052-0591;
   Belch, Jill JF/0000-0001-8280-6689; Struthers,
   Allan/0000-0002-2926-2528; Khan, Faisel/0000-0002-9889-0229
FU British Heart Foundation
FX This work was supported by a grant from the British Heart Foundation.
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NR 83
TC 22
Z9 24
U1 0
U2 8
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1755-5914
EI 1755-5922
J9 CARDIOVASC THER
JI Cardiovasc. Ther.
PY 2009
VL 27
IS 1
BP 49
EP 58
DI 10.1111/j.1755-5922.2008.00070.x
PG 10
WC Cardiac & Cardiovascular Systems; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Pharmacology & Pharmacy
GA 405SB
UT WOS:000263243400008
PM 19207480
OA Bronze
DA 2025-06-11
ER

PT J
AU Lent-Schochet, D
   McLaughlin, M
   Ramakrishnan, N
   Jialal, I
AF Lent-Schochet, Daniella
   McLaughlin, Matthew
   Ramakrishnan, Neeraj
   Jialal, Ishwarlal
TI Exploratory metabolomics of metabolic syndrome: A status report
SO WORLD JOURNAL OF DIABETES
LA English
DT Review
DE Metabolic syndrome; Syndrome X; Metabolomics; Amino acids; Carnitine;
   Inflammation; Biomarkers; Diabetes
ID TRIMETHYLAMINE-N-OXIDE; AMINO-ACID-METABOLISM; INSULIN-RESISTANCE;
   L-ARGININE; BRANCHED-CHAIN; ALANINE AMINOTRANSFERASE;
   CARDIOVASCULAR-DISEASE; OXIDATIVE STRESS; HISTIDINE SUPPLEMENTATION;
   DIETARY CHOLINE
AB Metabolic syndrome (MetS) is as a cluster of cardio-metabolic factors that greatly increase the risk of chronic diseases such as type II diabetes mellitus and atherosclerotic cardiovascular disease. In the United States, obesity, physical inactivity, aging, and genetics (to a minor extent) have arisen as risk factors for developing MetS. Although 35% of American adults suffer from MetS, its pathogenesis largely remains unknown. Worse, there is a lack of screening and optimum therapy for this disease. Researchers have consequently turned towards metabolomics to identify biomarkers to better understand MetS. The purpose of this review is to characterize various metabolites and their potential connections to MetS. Numerous studies have also characterized MetS as a disease of increased inflammation, and therefore this review also explores how metabolites play a role in various inflammatory pathways. Our review explores a broad range of metabolites including biogenic amines, branched chain amino acids, aromatic amines, phosphatidylcholines, as well as a variety of other molecules. We will explore their biochemical pathways and their potential role in serving as biomarkers.
C1 [Lent-Schochet, Daniella; McLaughlin, Matthew; Ramakrishnan, Neeraj; Jialal, Ishwarlal] Calif Northstate Univ, Coll Med, Metab & Clin Pathol, Elk Grove, CA 95757 USA.
   [Jialal, Ishwarlal] VA Med Ctr, Mather, CA 95655 USA.
RP Jialal, I (corresponding author), Calif Northstate Univ, Coll Med, 9700 West Taron Dr, Elk Grove, CA 95757 USA.
EM ishwarlal.jialal@cnsu.edu
RI Jialal, Ishwarlal/AAG-6218-2019
OI McLaughlin, Matthew/0000-0002-4471-4246
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NR 81
TC 63
Z9 66
U1 0
U2 14
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 7041 Koll Center Parkway, Suite 160, PLEASANTON, CA, UNITED STATES
EI 1948-9358
J9 WORLD J DIABETES
JI World J. Diabetes
PD JAN 15
PY 2019
VL 10
IS 1
BP 23
EP 36
DI 10.4239/wjd.v10.i1.23
PG 14
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA HJ0CP
UT WOS:000456825000003
PM 30697368
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Chen, YJ
   Lin, CL
   Li, CR
   Huang, SM
   Chan, JYH
   Fang, WH
   Chen, WL
AF Chen, Yu-Ju
   Lin, Chin-Ling
   Li, Chi-Rong
   Huang, Shih-Ming
   Chan, James Yi-Hsin
   Fang, Wen-Hui
   Chen, Wei-Liang
TI Associations among integrated psychoneuroimmunological factors and
   metabolic syndrome
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE Metabolic syndrome; Psychological distress; Perceived stress;
   Depression; Autonomic nervous function; Psychoneuroimmunology
ID HEART-RATE-VARIABILITY; C-REACTIVE PROTEIN; PERCEIVED STRESS;
   CARDIOVASCULAR-DISEASE; DEPRESSIVE SYMPTOMS; PREVALENCE; OBESITY; RISK;
   HYPERTENSION; ALLOSTASIS
AB Background: Metabolic syndrome (MetS) has been reported to cause considerable psychoneuroimmunology (PNI) disturbances such as, psychological distress, autonomic nervous imbalance, and impaired immune function. Associations among these psychoneuroimmunology (PNI) factors and their integrated effects with MetS and risk components of MetS necessitate further exploration.
   Objective: This study investigated associations among psychoneuroimmunological factors, their integrated effects with MetS and risk components of MetS.
   Methods: This was a cross-sectional study. Participants were recruited from two health management centers at a medical center in Northern Taiwan. Demographics and data on psychological distress (e.g., perceived stress and depression) were collected using self-reported questionnaires. Heart rate variability (HRV) and C-reactive protein values (CRP) were measured to evaluate participants' autonomic nervous function and immune reaction. The risk components of MetS (e.g., elevated blood pressure, impaired fasting glucose, dyslipidemia, and abdominal obesity) were identified according to the Taiwan-specific definition of MetS and were determined based on participants' health examination profiles.
   Results: A total of 345 participants with complete data were included for data analysis. Compared with healthy controls, participants with MetS exhibited higher depression scores (11.2 +/- 8.5 vs. 8.7 +/- 7.0), higher CRP values (2.1 +/- 2.5 vs. 0.7 +/- 1.0), and lower HRV (total power: 758.7 +/- 774.9 vs. 1064.4 +/- 1075.0). However, perceived stress in participants with MetS did not significantly differ from that of their healthy counterparts (p> 0,05). Univariate analyses indicated that associations among psychoneuroimmunological factors and MetS risk components were statistically heterogeneous: a) perceived stress and depression were significantly associated only with high blood glucose (p <0.05); b) CRP was significantly associated with all MetS risk components (p <0.05); and c) HRV was significantly associated with high triglycerides and high fasting blood glucose (p < 0.05). Multivariate analysis indicated that the integrated effects of depression, CRP, and HRV were significantly associated with MetS (p <0.01) after controlling for age and education level.
   Conclusions: Higher depression scores, higher CRP values, and lower HRV are independently and additively associated with MetS and risk components of MetS. Accordingly, a multidisciplinary approach to alleviating psychological distress, immune dysfunction, and autonomic nervous imbalance is recommended for promoting well-being in people with subclinical metabolic abnormalities or MetS to minimize downstream health consequences. (C) 2016 Elsevier Ltd. All rights reserved.
C1 [Chen, Yu-Ju] Natl Def Med Ctr, Sch Nursing, 114 161,Sec 6,Minquan E Rd, Taipei, Taiwan.
   [Lin, Chin-Ling] Natl Cheng Kung Univ Hosp, Dept Internal Med, Dou Liou Branch, Tainan, Taiwan.
   [Li, Chi-Rong] Taichung Hosp, Minist Hlth & Welf, Dept Teaching & Res, Taichung, Taiwan.
   [Huang, Shih-Ming] Natl Def Med Ctr, Dept & Grad Inst Biochem, Taipei, Taiwan.
   [Chan, James Yi-Hsin] Natl Def Med Ctr, Dept Microbiol & Immunol, Taipei 114, Taiwan.
   [Chan, James Yi-Hsin] Triserv Gen Hosp, Dept Med Res, Natl Def Med Ctr, Taipei 114, Taiwan.
   [Fang, Wen-Hui; Chen, Wei-Liang] Triserv Gen Hosp, Dept Family & Community Med, Natl Def Med Ctr, Taipei, Taiwan.
   [Chen, Wei-Liang] Triserv Gen Hosp, Div Family Med, Natl Def Med Ctr, Taipei, Taiwan.
C3 National Defense Medical Center; National Cheng Kung University;
   National Cheng Kung University Hospital; National Defense Medical
   Center; National Defense Medical Center; Tri-Service General Hospital;
   National Defense Medical Center; National Defense Medical Center;
   Tri-Service General Hospital; Tri-Service General Hospital; National
   Defense Medical Center
RP Chen, YJ (corresponding author), Natl Def Med Ctr, Sch Nursing, 114 161,Sec 6,Minquan E Rd, Taipei, Taiwan.
EM judychen37@gmail.com
RI Li, Chi-Rong/J-9914-2013
OI Li, Chi-Rong/0000-0002-0314-8284
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NR 55
TC 7
Z9 7
U1 0
U2 10
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
EI 1873-3360
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD DEC
PY 2016
VL 74
BP 342
EP 349
DI 10.1016/j.psyneuen.2016.09.027
PG 8
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA EB6VW
UT WOS:000387524700040
PM 27728874
DA 2025-06-11
ER

PT J
AU Krivosíková, Z
   Gajdos, M
   Sebeková, K
AF Krivosikova, Zora
   Gajdos, Martin
   Sebekova, Katarina
TI Vitamin D Levels Decline with Rising Number of Cardiometabolic Risk
   Factors in Healthy Adults: Association with Adipokines, Inflammation,
   Oxidative Stress and Advanced Glycation Markers
SO PLOS ONE
LA English
DT Article
ID C-REACTIVE PROTEIN; CARDIOVASCULAR-DISEASE RISK; CYTOKINE-INDUCED
   APOPTOSIS; SERUM 25-HYDROXYVITAMIN D; NF-KAPPA-B; END-PRODUCTS;
   1,25-DIHYDROXYVITAMIN D-3; INSULIN-RESISTANCE; CALCITRIOL BLUNTS;
   SOLUBLE RECEPTOR
AB Introduction
   Hypovitaminosis D associates with obesity, insulin resistance, hypertension, and dyslipoproteinemia. We asked whether the presence of multiple cardiometabolic risk factors, and which particular combination, exerts additive negative effects on 25(OH)D-3 levels; and whether 25(OH)D-3 levels associate with markers of inflammation and oxidative stress.
   Subjects and Methods
   In non-diabetic medication-free adults central obesity (waist-to-height ratio > 0.5); elevated blood pressure (systolic BP >= 130 mm Hg and/or diastolic BP >= 85 mm Hg); increased atherogenic risk (log(TAG/HDL) >= 0.11); and insulin resistance (QUICKI < 0.322) were considered as cardiometabolic risk factors. 25(OH)D-3 status was classified as deficiency (25(OH)D-3 <= 20 ng/ml); insufficiency (levels between 20-to-30 ng/ml), or as satisfactory (> 30 ng/ml). Plasma adipokines, inflammatory and oxidative stress markers, advanced glycation end-products, and their soluble receptor were determined.
   Results
   162 subjects were cardiometabolic risk factors-free, 162 presented increased (i.e. 1 or 2), and 87 high number (i.e. 3 or 4) of cardiometabolic risk factors. Mean 25(OH) D3 decreased with rising number of manifested risk factors (36 +/- 14 ng/ml, 33 +/- 14 ng/ml, and 31 +/- 15 ng/ml, respectively; pANOVA: 0.010), while prevalence of hypovitaminosis D did not differ significantly. Elevated blood pressure and insulin resistance appeared as significant determinants of hypovitaminosis D. Subjects presenting these risk factors concurrently displayed the lowest 25(OH)D-3 levels (29 +/- 15 ng/ml). Plasma adipokines, inflammatory and oxidative stress markers, advanced glycation end-products, and their soluble receptor generally differed significantly between the groups, but only advanced oxidation protein products and advanced glycation end-products associated fluorescence of plasma showed significant independent association with 25(OH)D-3 levels.
   Conclusion
   In apparently healthy adults increasing number of cardiometabolic risk factors associates with poorer 25(OH)D-3 status, while the association between 25(OH)D-3 status and inflammatory or oxidative stress markers remains equivocal.
C1 [Krivosikova, Zora; Gajdos, Martin] Slovak Med Univ, Fac Med, Dept Clin & Expt Pharmacotherapy, Bratislava, Slovakia.
   [Sebekova, Katarina] Comenius Univ, Fac Med, Inst Mol BioMed, Bratislava, Slovakia.
C3 Slovak Medical University Bratislava; Comenius University Bratislava;
   Comenius University Bratislava
RP Sebeková, K (corresponding author), Comenius Univ, Fac Med, Inst Mol BioMed, Bratislava, Slovakia.
EM kata.sebekova@gmail.com
RI ; Sebekova, Katarina/H-4906-2016
OI Krivosikova, Zora/0000-0002-1271-9923; Sebekova,
   Katarina/0000-0002-9641-9265
FU Slovak Ministry of Health [2005/27-SZU-05]; Operational Research and
   Development Program from the European Regional Development Fund
   [26240120033]
FX This work was supported by the Slovak Ministry of Health,
   https://www.minedu.sk/vedeckagrantova-agentura-msvvas-sr-a-sav-vega/,
   grant No. 2005/27-SZU-05 (to MG) and Operational Research and
   Development Program financed from the European Regional Development
   Fund, http://www.asfeu.sk/operacny-program-vyskum-a-vyvoj/opatrenie-41/,
   grant No.: 26240120033 (to Slovak Medical University). The funders had
   no role in study design, data collection and analysis, decision to
   publish, or preparation of the manuscript.
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NR 79
TC 19
Z9 20
U1 0
U2 20
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JUN 29
PY 2015
VL 10
IS 6
AR e0131753
DI 10.1371/journal.pone.0131753
PG 17
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA CN1BL
UT WOS:000358150400152
PM 26120828
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Freitas, C
   Deschênes, S
   Au, B
   Smith, K
   Schmitz, N
AF Freitas, Cassandra
   Deschenes, Sonya
   Au, Bonnie
   Smith, Kimberley
   Schmitz, Norbert
TI Evaluating lifestyle and health-related characteristics of older adults
   with co-occurring depressive symptoms and cardiometabolic abnormalities
SO INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
LA English
DT Article
DE depression; cardiometabolic factors; lifestyle; population-based study
ID SELF-RATED HEALTH; METABOLIC SYNDROME; RISK-FACTOR;
   CARDIOVASCULAR-DISEASE; US POPULATION; PREVALENCE; ASSOCIATION; OBESITY;
   SAMPLE
AB Objective: Comorbid depression and cardiometabolic abnormalities might represent an important subgroup of depression. The aim of the present study was to evaluate lifestyle and health-related characteristics of individuals with both depressive symptoms and cardiometabolic abnormalities.
   Methods: Data were from the English Longitudinal Study of Ageing. The sample was comprised of 5365 adults aged 50-80 years. High depressive symptoms were based on the eight-item Center for Epidemiologic Studies - Depression scale. Cardiometabolic abnormalities were defined as having >= 3 cardiometabolic risk factors (hypertension, impaired glycemic control, systemic inflammation, low high-density lipoprotein cholesterol, hypertriglyceridemia, and central obesity). Four groups were created based on Center for Epidemiologic Studies - Depression scores and cardiometabolic abnormalities: those with (i) comorbid depressive symptoms and cardiometabolic abnormalities (DCM); (ii) depressive symptoms only (DnoCM); (iii) cardiometabolic abnormalities only; and (iv) neither depressive symptoms nor cardiometabolic abnormalities. Lifestyle and health-related characteristics of the four groups were compared using chi-square tests. A modified Poisson regression analysis was performed to compare the DCM and the DnoCM groups with respect to lifestyle and health-related characteristics.
   Results: Those in the DCM group were significantly less physically active (p= 0.003), had poorer self-rated health (p< 0.001), had lower income (p= 0.001), and were more likely to be retired (p< 0.001) than those in the DnoCM group. The pattern of results remained after controlling for other lifestyle and health-related factors.
   Conclusion: These results provide support for a cardiometabolic subgroup of depression that is associated with physical inactivity, poorer self-rated health, lower income, and retirement. Copyright (C) 2015 John Wiley & Sons, Ltd.
C1 [Freitas, Cassandra; Au, Bonnie; Schmitz, Norbert] McGill Univ, Dept Epidemiol Biostat & Occupat Hlth, Montreal, PQ, Canada.
   [Freitas, Cassandra; Deschenes, Sonya; Au, Bonnie; Schmitz, Norbert] Douglas Mental Hlth Univ Inst, Montreal, PQ, Canada.
   [Deschenes, Sonya; Schmitz, Norbert] McGill Univ, Dept Psychiat, Montreal, PQ, Canada.
   [Smith, Kimberley] Brunel Univ London, Dept Life Sci, Uxbridge, Middx, England.
C3 McGill University; McGill University; Brunel University
RP Schmitz, N (corresponding author), McGill Univ, Dept Epidemiol Biostat & Occupat Hlth, Montreal, PQ, Canada.
EM Norbert.schmitz@douglas.mcgill.ca
RI Schmitz, Norbert/AAH-3624-2020; Deschenes, Sonya/G-6341-2017; Schmitz,
   Norbert/A-5177-2010
OI Smith, Kimberley/0000-0002-1323-627X; Schmitz,
   Norbert/0000-0001-7777-6323
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NR 48
TC 6
Z9 7
U1 0
U2 9
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0885-6230
EI 1099-1166
J9 INT J GERIATR PSYCH
JI Int. J. Geriatr. Psychiatr.
PD JAN
PY 2016
VL 31
IS 1
BP 66
EP 75
DI 10.1002/gps.4290
PG 10
WC Geriatrics & Gerontology; Gerontology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Psychiatry
GA DA7ZU
UT WOS:000368024900009
PM 25827712
DA 2025-06-11
ER

PT J
AU Rhudy, JL
   Huber, FA
   Toledo, TA
   Kell, PA
   Street, EN
   Shadlow, JO
AF Rhudy, Jamie L.
   Huber, Felicitas A.
   Toledo, Tyler A.
   Kell, Parker A.
   Street, Erin N.
   Shadlow, Joanna O.
TI Psychosocial and cardiometabolic predictors of chronic pain onset in
   Native Americans: serial mediation analyses of 2-year prospective data
   from the Oklahoma Study of Native American Pain Risk
SO PAIN
LA English
DT Article
DE Chronic pain; Descending inhibition; Quantitative sensory testing;
   Ethnic differences; Native Americans
ID NOCICEPTIVE FLEXION REFLEX; ADVERSE CHILDHOOD EXPERIENCES; PERCEIVED
   RACIAL-DISCRIMINATION; PHYSICAL-ACTIVITY QUESTIONNAIRE; NERVE-FIBER
   DENSITIES; TEMPORAL SUMMATION; WITHDRAWAL REFLEX; CATASTROPHIZING SCALE;
   PERIPHERAL NEUROPATHY; DIABETIC-NEUROPATHY
AB Chronic pain results in considerable suffering, as well as significant economic and societal costs. Previous evidence suggests that Native Americans (NAs) have higher rates of chronic pain than other U.S. racial or ethnic groups, but the mechanisms contributing to this pain disparity are poorly understood. The Oklahoma Study of Native American Pain Risk was developed to address this issue and recruited healthy, pain-free NAs and non-Hispanic Whites. Cross-sectional analyses identified several measures of adversity (eg, trauma and discrimination), cognitive-affective factors (perceived stress and pain-related anxiety/catastrophizing), and cardiometabolic factors (eg, body mass index, blood pressure, and heart rate variability) that were associated with pronociceptive processes (eg, central sensitization, descending inhibition, and hyperalgesia). Every 6-months after enrollment, eligible participants (N = 277) were recontacted and assessed for the onset of chronic pain. This study examines predictors of chronic pain onset in the 222 participants (80%) who responded over the first 2 years. The results show that NAs developed chronic pain at a higher rate than non-Hispanic Whites (OR = 2.902, P < 0.05), even after controlling for age, sex, income, and education. Moreover, serial mediation models identified several potential pathways to chronic pain onset within the NA group. These paths included perceived discrimination, psychological stress, pain-related anxiety, a composite measure of cardiometabolic risk, and impaired descending inhibition of spinal nociception (assessed from conditioned pain modulation of the nociceptive flexion reflex). These results provide the first prospective evidence for a pain disparity in NAs that seems to be promoted by psychosocial, cardiometabolic, and pronociceptive mechanisms.
C1 [Rhudy, Jamie L.; Huber, Felicitas A.; Toledo, Tyler A.; Kell, Parker A.; Street, Erin N.; Shadlow, Joanna O.] Univ Tulsa, Dept Psychol, 800 South Tucker Dr, Tulsa, OK 74104 USA.
C3 University of Tulsa
RP Rhudy, JL (corresponding author), Univ Tulsa, Dept Psychol, 800 South Tucker Dr, Tulsa, OK 74104 USA.
EM jamie-rhudy@utulsa.edu
RI Kell, Parker/GXM-1322-2022
FU National Institute on Minority Health and Health Disparities of the
   National Institute of Health [R01MD007807]; University of Tulsa Office
   of Research and Sponsored Programs
FX The authors thank Edward Lannon, Bethany Kuhn, Shreela Palit, Michael
   Payne, Cassandra Sturycz, Natalie Hellman, Yvette Guereca, Mara Demuth
   Burkhart Hahn, Heather Coleman, Kathryn Thompson, Jessica Fisher, Samuel
   Herbig, Ky'Lee Barnoski, Garrett Newsom, and Lucinda Chee for their help
   with data collection, as well as Dr. John Chaney for his consultation on
   the project. This research was supported by the National Institute on
   Minority Health and Health Disparities of the National Institute of
   Health under Award No. R01MD007807, and faculty research grants from The
   University of Tulsa Office of Research and Sponsored Programs. The
   content is solely the responsibility of the authors, and does not
   necessarily reflect the views of the National Institutes of Health,
   National Science Foundation, Indian Health Service, or the Cherokee
   Nation. Aspects of this research have been presented at the 2019
   American Pain Society conference. The authors report no conflicts of
   interest. Neither the study nor the analyses were preregistered. Data
   and analytic codes will be made available on request from the
   corresponding author.
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NR 120
TC 9
Z9 10
U1 1
U2 7
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0304-3959
EI 1872-6623
J9 PAIN
JI Pain
PD MAY
PY 2022
VL 163
IS 5
BP E654
EP E674
DI 10.1097/j.pain.0000000000002458
PG 21
WC Anesthesiology; Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Anesthesiology; Neurosciences & Neurology
GA 0N1RJ
UT WOS:000782623300005
PM 34433767
OA Green Accepted
DA 2025-06-11
ER

PT J
AU de Louw, EJ
   Paans, NPG
   Sonnenberg, CM
   Konz, H
   Meesters, PD
   van Grootheest, D
   Oudega, ML
   Rhebergen, D
   Kerssens, C
   Comijs, HC
   Stek, ML
   Dols, A
AF de Louw, Emma J.
   Paans, Nadine P. G.
   Sonnenberg, Caroline M.
   Konz, Hugo
   Meesters, Paul D.
   van Grootheest, Daniel
   Oudega, Mardien L.
   Rhebergen, Didi
   Kerssens, Cora
   Comijs, Hannie C.
   Stek, Max L.
   Dols, Annemiek
TI Metabolic syndrome rates in older patients with severe mental illness
   after five years of follow-up and the association with mortality
SO INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
LA English
DT Article
DE elderly; metabolic screening; metabolic syndrome; mortality; severe
   mental illness
ID BIPOLAR DISORDER; SCHIZOPHRENIA; GUIDELINES; RISK
AB Objectives: To establish the course of metabolic syndrome (MS) rates in older patients with severe mental illness (SMI) after 5-year follow-up and evaluate whether MS at baseline is associated with mortality or diabetes at follow-up.
   Methods: Patients (>60 years of age) with SMI (N = 100) were included at a specialized mental health outpatient clinic. Metabolic parameters were collected from patients' medical files at baseline and after 5-year follow-up.
   Results: Follow-up data were available of 98 patients (98%); nine patients had died. Parameters of MS were available of 76 patients; 34.2% were diagnosed with MS. This was not significantly different compared with baseline (46.1%). MS at baseline was not significantly associated with mortality or development of diabetes at follow-up.
   Conclusions: In older patients with SMI, the rates of MS may reach a plateau. Screening for MS in older patients treated at a specialized mental health outpatient clinic may generate attention for their somatic health and treatment for the components of MS that may in turn have a positive effect on their outcome. However, further research with larger sample sizes is needed in order to confirm these findings.
C1 [de Louw, Emma J.; Sonnenberg, Caroline M.; van Grootheest, Daniel; Oudega, Mardien L.; Rhebergen, Didi; Kerssens, Cora; Comijs, Hannie C.; Stek, Max L.; Dols, Annemiek] Vrije Univ Amsterdam Med Ctr, Dept Old Age Psychiat, GGZ InGeest, NL-1070 BB Amsterdam, Netherlands.
   [Paans, Nadine P. G.; Oudega, Mardien L.; Rhebergen, Didi; Comijs, Hannie C.; Stek, Max L.; Dols, Annemiek] Vrije Univ Amsterdam Med Ctr, Amsterdam Publ Hlth Res Inst, Amsterdam, Netherlands.
   [Konz, Hugo] Parnassia Grp, The Hague, Netherlands.
   [Meesters, Paul D.] Friesland Mental Hlth Serv, Dept Res & Educ, Leeuwarden, Netherlands.
C3 Vrije Universiteit Amsterdam; VU UNIVERSITY MEDICAL CENTER; Vrije
   Universiteit Amsterdam; VU UNIVERSITY MEDICAL CENTER; Parnassia
   Psychiatric Institute
RP de Louw, EJ (corresponding author), Vrije Univ Amsterdam Med Ctr, Dept Old Age Psychiat, GGZ InGeest, NL-1070 BB Amsterdam, Netherlands.
EM emmajdelouw@gmail.com
RI Konz, Hugo/NAZ-6114-2025; Meesters, Paul/AAM-9065-2020
OI Oudega, Mardien/0000-0002-1521-1682; Dols, Annemiek/0000-0003-1964-0318
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NR 16
TC 5
Z9 5
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0885-6230
EI 1099-1166
J9 INT J GERIATR PSYCH
JI Int. J. Geriatr. Psychiatr.
PD FEB
PY 2019
VL 34
IS 2
BP 333
EP 336
DI 10.1002/gps.5025
PG 4
WC Geriatrics & Gerontology; Gerontology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Psychiatry
GA HL6BJ
UT WOS:000458818500016
PM 30430644
DA 2025-06-11
ER

PT J
AU Sarkar, S
   Prasanna, VS
   Das, P
   Suzuki, H
   Fujihara, K
   Kodama, S
   Sone, H
   Sreedhar, R
   Velayutham, R
   Watanabe, K
   Arumugam, S
AF Sarkar, Sulogna
   Prasanna, Vani S.
   Das, Pamelika
   Suzuki, Hiroshi
   Fujihara, Kazuya
   Kodama, Satoru
   Sone, Hirohito
   Sreedhar, Remya
   Velayutham, Ravichandiran
   Watanabe, Kenichi
   Arumugam, Somasundaram
TI The onset and the development of cardiometabolic aging: an insight into
   the underlying mechanisms
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Review
DE cardiometabolic risk; aging; inflammation; immune dysfunction;
   mitochondrial dysfunction; oxidative stress; gut microbiome dysbiosis;
   genetic and environmental contributors
ID GLYCATION END-PRODUCTS; ACTIVATED PROTEIN-KINASE; NECROSIS-FACTOR-ALPHA;
   METABOLIC SYNDROME; OXIDATIVE STRESS; INSULIN-RESISTANCE; MITOCHONDRIAL
   DYSFUNCTION; CARDIOVASCULAR-DISEASE; UP-REGULATION; DIASTOLIC FUNCTION
AB Metabolic compromise is crucial in aggravating age-associated chronic inflammation, oxidative stress, mitochondrial damage, increased LDL and triglycerides, and elevated blood pressure. Excessive adiposity, hyperglycemia, and insulin resistance due to aging are associated with elevated levels of damaging free radicals, inducing a proinflammatory state and hampering immune cell activity, leading to a malfunctioning cardiometabolic condition. The age-associated oxidative load and redox imbalance are contributing factors for cardiometabolic morbidities via vascular remodelling and endothelial damage. Recent evidence has claimed the importance of gut microbiota in maintaining regular metabolic activity, which declines with chronological aging and cardiometabolic comorbidities. Genetic mutations, polymorphic changes, and environmental factors strongly correlate with increased vulnerability to aberrant cardiometabolic changes by affecting key physiological pathways. Numerous studies have reported a robust link between biological aging and cardiometabolic dysfunction. This review outlines the scientific evidence exploring potential mechanisms behind the onset and development of cardiovascular and metabolic issues, particularly exacerbated with aging.
C1 [Sarkar, Sulogna; Prasanna, Vani S.; Das, Pamelika; Arumugam, Somasundaram] Natl Inst Pharmaceut Educ & Res NIPER Kolkata, Dept Pharmacol & Toxicol, Kolkata, W Bengal, India.
   [Suzuki, Hiroshi; Fujihara, Kazuya; Kodama, Satoru; Sone, Hirohito] Niigata Univ, Grad Sch Med & Dent Sci, Dept Hematol Endocrinol & Metab, Niigata, Japan.
   [Sreedhar, Remya] Sister Nivedita Univ, Sch Pharm, Kolkata, W Bengal, India.
   [Velayutham, Ravichandiran] Natl Inst Pharmaceut Educ & Res NIPER Kolkata, Kolkata, W Bengal, India.
   [Watanabe, Kenichi] Niigata Univ, Grad Sch Med & Dent Sci, Dept Lab Med & Clin Epidemiol Prevent Noncommunica, Niigata, Japan.
C3 Niigata University; Niigata University
RP Arumugam, S (corresponding author), Natl Inst Pharmaceut Educ & Res NIPER Kolkata, Dept Pharmacol & Toxicol, Kolkata, W Bengal, India.; Watanabe, K (corresponding author), Niigata Univ, Grad Sch Med & Dent Sci, Dept Lab Med & Clin Epidemiol Prevent Noncommunica, Niigata, Japan.
EM somasundaram.niperk@nic.in; somasundaram143@gmail.com
RI VELAYUTHAM, RAVICHANDIRAN/HGU-8028-2022; Sone, Hirohito/ABC-9346-2021;
   Arumugam, Somasundaram/AFQ-5841-2022
FX The author(s) declare that no financial support was received for the
   research, authorship, and/or publication of this article. This article
   received no external funding.
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NR 197
TC 0
Z9 0
U1 1
U2 2
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD SEP 26
PY 2024
VL 15
AR 1447890
DI 10.3389/fphar.2024.1447890
PG 13
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA I2Z5Z
UT WOS:001328992300001
PM 39391689
OA gold
DA 2025-06-11
ER

PT J
AU Gheorman, V
   Dinescu, VC
   Criciotoiu, O
   Stanca, D
   Calborean, V
   Mita, A
   Miscoci, A
   Davitoiu, DV
   Baleanu, VD
   Nedelcuta, RM
   Dinescu, SN
   Dijmarescu, AL
   Voiculescu, DI
   Udristoiu, I
AF Gheorman, Victor
   Dinescu, Venera Cristina
   Criciotoiu, Oana
   Stanca, Diana
   Calborean, Veronica
   Mita, Adrian
   Miscoci, Alina
   Davitoiu, Dragos Virgil
   Baleanu, Vlad Dumitru
   Nedelcuta, Ramona-Mihaela
   Dinescu, Sorin Nicolae
   Dijmarescu, Anda Lorena
   Voiculescu, Daniel-Iulian
   Udristoiu, Ion
TI Clinical and Biochemical Changes Induced by Alcohol at the Patients with
   Mental Illness
SO REVISTA DE CHIMIE
LA English
DT Article
DE alcoholism; mental illness; biochemical parameters
ID METABOLIC SYNDROME; VIRAL-HEPATITIS; LIVER; DISEASE; RISK; STRESS
AB Alcoholism use disorders are very frequent present all over the world. The use of alcohol is responsable for many behavioral symptoms like impulsivity, violence, depressive mood and anxiety. The aim of our research was to find the clinical and the biochemical changes induced by alcohol at the patient with mental illness.
C1 [Gheorman, Victor; Udristoiu, Ion] Univ Med & Pharm Craiova, Neuropsychiat Hosp Craiova, Dept Psychiat, Craiova 200473, Romania.
   [Dinescu, Venera Cristina] Univ Med & Pharm Craiova, Hlth Promot & Ocupat Med Dept, 2 Petru Rares Str, Craiova 200349, Romania.
   [Criciotoiu, Oana; Stanca, Diana] Univ Med & Pharm Craiova, Neuropsychiat Hosp Craiova, Neurol Dept, 99 Calea Bucuresti Str, Craiova 200473, Romania.
   [Calborean, Veronica] Univ Med & Pharm Craiova, Cardiol Dept, 2 Petru Rares Str, Craiova 200349, Romania.
   [Mita, Adrian] Univ Med & Pharm Craiova, Filantropia Hosp Craiova, Internal Med Dept, 1 Filantropiei Str, Craiova, Romania.
   [Miscoci, Alina] Univ Med & Pharm Craiova, Internal Med Dept, 2 Petru Rares Str, Craiova 200349, Romania.
   [Davitoiu, Dragos Virgil] Univ Med & Pharm Bucharest, Surg Dept, Clin Emergency Hosp Sf Pantelimon Bucharest, 340-343 Pantelimon Rd, Bucharest 021659, Romania.
   [Baleanu, Vlad Dumitru] Univ Med & Pharm Craiova, Clin Emergency Hosp Sf Pantelimon Bucharest, Surg Dept Clin, 340-343 Pantelimon Rd, Bucharest 021659, Romania.
   [Nedelcuta, Ramona-Mihaela] Univ Med & Pharm Craiova, Dept Pediat, 2 Petru Rares Str, Craiova 200349, Romania.
   [Dinescu, Sorin Nicolae] Univ Med & Pharm Craiova, Epidemiol & Primary Hlth Care Dept, 2 Petru Rares Str, Craiova 200349, Romania.
   [Dijmarescu, Anda Lorena] Univ Med & Pharm Craiova, Filantropia Clin Hosp Craiova, Obstret Gynecol Dept, 1 Filantropiei Str, Craiova 200143, Romania.
   [Voiculescu, Daniel-Iulian] Univ Emergency Hosp Bucharest, Dept Surg, Univ Med & Pharm Carol Davila Bucharest, 169 Splaiul Indepenei, Bucharest 050098, Romania.
C3 University of Medicine & Pharmacy of Craiova; University of Medicine &
   Pharmacy of Craiova; University of Medicine & Pharmacy of Craiova;
   University of Medicine & Pharmacy of Craiova; University of Medicine &
   Pharmacy of Craiova; University of Medicine & Pharmacy of Craiova; Carol
   Davila University of Medicine & Pharmacy; University of Medicine &
   Pharmacy of Craiova; University of Medicine & Pharmacy of Craiova;
   University of Medicine & Pharmacy of Craiova; University of Medicine &
   Pharmacy of Craiova; Carol Davila University of Medicine & Pharmacy
RP Calborean, V (corresponding author), Univ Med & Pharm Craiova, Cardiol Dept, 2 Petru Rares Str, Craiova 200349, Romania.
EM calborean.veronica@yahoo.com
RI Davitoiu, Dragos/P-9703-2017; VLAD, BALEANU/GXH-4036-2022; dijmarescu,
   lorena/KIB-5337-2024; Gheorman, Victor/AAR-8767-2021; Adrian,
   Mita/HED-7666-2022; Voiculescu, Daniel/AAY-9590-2020; GÂLCEAVĂ,
   OANA/IQU-5169-2023; Dinescu, Venera/MFH-5020-2025; Stanca, Iulia
   Diana/GYU-2717-2022; Voiculescu, Daniel/AAB-4912-2020
OI Stanca, Iulia Diana/0000-0002-5965-8590; VLAD,
   BALEANU/0000-0002-7010-8813; Voiculescu, Daniel/0000-0001-8998-658X
CR Avramescu C, 2010, ROM J MORPHOL EMBRYO, V51, P633
   Baleanu VD, 2018, REV CHIM-BUCHAREST, V69, P1740
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   Calborean V, 2018, REV CHIM-BUCHAREST, V69, P2461
   Calborean V, 2018, J CARDIOVASC EMERG, V4, P101, DOI 10.2478/jce-2018-0009
   Calborean V, 2018, REV CHIM-BUCHAREST, V69, P1527
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   Calborean V, 2017, REV CHIM-BUCHAREST, V68, P3010
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NR 37
TC 13
Z9 13
U1 0
U2 14
PU CHIMINFORM DATA S A
PI BUCHAREST
PA CALEA PLEVNEI NR 139, SECTOR 6, BUCHAREST R-77131, ROMANIA
SN 0034-7752
J9 REV CHIM-BUCHAREST
JI Rev. Chim.
PD APR
PY 2019
VL 70
IS 4
BP 1406
EP 1410
PG 5
WC Chemistry, Multidisciplinary; Engineering, Chemical
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Chemistry; Engineering
GA IA2JK
UT WOS:000469387200063
DA 2025-06-11
ER

PT J
AU Laudisio, A
   Marzetti, E
   Pagano, F
   Pozzi, G
   Bernabei, R
   Zuccalà, G
AF Laudisio, Alice
   Marzetti, Emanuele
   Pagano, Francesco
   Pozzi, Gino
   Bernabei, Roberto
   Zuccala, Giuseppe
TI Depressive Symptoms and Metabolic Syndrome: Selective Association in
   Older Women
SO JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY
LA English
DT Article
DE depressive symptoms; metabolic syndrome; elderly populations;
   epidemiology
ID CARDIOVASCULAR RISK; HYPERCORTISOLEMIC DEPRESSION; GENDER DIFFERENCES;
   HEART-FAILURE; YOUNG-ADULTS; HEALTH; PREVALENCE; MORTALITY; COMMUNITY;
   MEN
AB The metabolic syndrome (MetS) is being increasingly found in older populations. Depressive symptoms are prevalent in elderly populations, and they are associated with adverse outcomes, chiefly cardiovascular. The aim of this study was to evaluate the association of the 30-item geriatric depression scale (GDS) score with MetS, as defined according to the National Cholesterol Education Program's Adult Treatment Panel III (ATP-III) criteria, in all 353 participants aged 75+ years living in Tuscania (Italy). Metabolic syndrome was associated with the GDS score in a multivariable linear regression analysis in women (beta s= 2.14, 95% CI = 0.14 to 4.14; P = .036), but not in men (beta = -.84, 95% CI = -3.17 to 1.49; P = .476), after adjusting. Analysis of the interaction term confirmed (P = .022) that such an association differed according to sex. Metabolic syndrome is independently associated with depressive symptoms in community-dwelling older women. Older women with depression should be prompted to undergo screening for MetS. Conversely, elderly women with MetS should be assessed for affective disorders.
C1 [Laudisio, Alice; Pagano, Francesco; Bernabei, Roberto; Zuccala, Giuseppe] Catholic Univ Med, Dept Gerontol & Geriatr, Rome, Italy.
   [Pozzi, Gino] Catholic Univ Med, Inst Psychiat & Psychol, Rome, Italy.
   [Marzetti, Emanuele] Univ Florida, Coll Med, Biochem Aging Lab, Inst Aging,Div Biol Aging,Dept Aging & Geriatr, Gainesville, FL USA.
C3 Catholic University of the Sacred Heart; Catholic University of the
   Sacred Heart; State University System of Florida; University of Florida
RP Laudisio, A (corresponding author), L Go F Vito 1, I-00168 Rome, Italy.
EM postalice@tiscali.it
RI Zuccalà, Giuseppe/AAC-4677-2022; Bernabei, Roberto/AAB-2704-2019;
   Laudisio, Alice/AHI-1049-2022; Pagano, Francesco/AAT-2060-2021;
   Marzetti, Emanuele/A-9430-2010
OI BERNABEI, Roberto/0000-0002-9197-004X; Marzetti,
   Emanuele/0000-0001-9567-6983; Zuccala, Giuseppe/0000-0002-2567-2220;
   Laudisio, Alice/0000-0002-6167-053X
FU Italian Ministry of Health [SS9.4.2]
FX This research was partially supported as a "targeted project'' (SS9.4.2)
   by the Italian Ministry of Health.
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NR 44
TC 26
Z9 31
U1 0
U2 6
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0891-9887
EI 1552-5708
J9 J GERIATR PSYCH NEUR
JI J. Geriatr. Psychiatry Neurol.
PD DEC
PY 2009
VL 22
IS 4
BP 215
EP 222
DI 10.1177/0891988709335793
PG 8
WC Geriatrics & Gerontology; Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Neurosciences & Neurology; Psychiatry
GA 520SC
UT WOS:000271867200001
PM 19423752
DA 2025-06-11
ER

PT J
AU Paredes, S
   Ribeiro, L
AF Paredes, Silvia
   Ribeiro, Laura
TI Cortisol: the villain in Metabolic Syndrome?
SO REVISTA DA ASSOCIACAO MEDICA BRASILEIRA
LA English
DT Article
DE stress; glucocorticoids; obesity; insulin resistance; metabolic
   Syndrome; 11 beta Hydroxysteroid; dehydrogenase
ID 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1; PITUITARY-ADRENAL-AXIS;
   ADIPOSE-TISSUE; 11BETA-HYDROXYSTEROID DEHYDROGENASE; VISCERAL OBESITY;
   SOCIAL STRESS; VITAMIN-D; GLUCOCORTICOIDS; INFLAMMATION; INSULIN
AB Objective: This article reviews the state of the art regarding the association between glucocorticoid actions and both obesity and insulin resistance, two main features of the metabolic syndrome.
   Methods: A methodological assessment of the literature on PubMed and SciELO databases was conducted by using the following terms: stress, metabolic syndrome, glucocorticoids, obesity, insulin resistance, hypothalamic-pituitary-adrenal-axis and 11 beta-hydroxysteroid dehydrogenase.
   Results: Chronic stress, mainly through hypothalamic-pituitary-adrenal axis dysregulation, promotes the accumulation of visceral fat. Reciprocally, obesity promotes a systemic low-grade inflammation state, mediated by increased adipokine secretion, which can chronically stimulate and disturb stress system. This vicious cycle, probably initiated by visceral adipose tissue dysfunction, might be the trigger for the development of metabolic syndrome.
   Conclusion: Given the strong evidences linking glucocorticoid release, obesity and type 2 diabetes, better understanding of the mechanisms underlying this connection might be useful for prevention and treatment of the metabolic syndrome.
C1 [Paredes, Silvia] Univ Porto, Fac Med, P-4100 Oporto, Portugal.
   [Ribeiro, Laura] Univ Porto, Fac Med, Dept Biochem, P-4100 Oporto, Portugal.
   [Ribeiro, Laura] Univ Porto, Fac Med, Ctr Med Educ, P-4100 Oporto, Portugal.
C3 Universidade do Porto; Universidade do Porto; Universidade do Porto
RP Ribeiro, L (corresponding author), Fac Med, Dept Biochem, P-4200319 Oporto, Portugal.
EM Inbeiro@med.up.pt
RI de Sousa Paredes, Sílvia/AAA-9992-2020; Ribeiro, Laura/ACI-8724-2022;
   Sousa Paredes, Silvia Cristina de/J-2023-2016
OI Ribeiro, Laura/0000-0003-1181-9217; Sousa Paredes, Silvia Cristina
   de/0000-0002-1682-3031
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NR 53
TC 40
Z9 46
U1 0
U2 22
PU ASSOC MEDICA BRASILEIRA
PI SAO PAULO
PA RUA SAO CARLOS DO PINHAL 324, CAIXA POSTAL 8904, SAO PAULO, SP, BRAZIL
EI 1806-9282
J9 REV ASSOC MED BRAS
JI Rev. Assoc. Med. Bras.
PD JAN-FEB
PY 2014
VL 60
IS 1
BP 84
EP 92
DI 10.1590/1806-9282.60.01.017
PG 9
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA AF5BK
UT WOS:000334728800016
PM 24918858
OA Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Strzelecki, D
   Kotlicka-Antczak, M
   Kaczmarek, B
   Jerczynska, H
   Wysokinski, A
AF Strzelecki, Dominik
   Kotlicka-Antczak, Magdalena
   Kaczmarek, Bartosz
   Jerczynska, Hanna
   Wysokinski, Adam
TI Serum levels of neuropeptide Y in patients with chronic schizophrenia
   during treatment augmentation with sarcosine (results of the
   double-blind randomized controlled PULSAR study)
SO HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL
LA English
DT Article
DE depression; neuropeptide Y; NMDA receptor; sarcosine; schizophrenia
ID QUALITY-OF-LIFE; METABOLIC SYNDROME; NMDA RECEPTOR; DEPRESSION; STRESS;
   ANXIETY; NPY; ASSOCIATION; PARAMETERS; CLOZAPINE
AB Objective Modulation of glutamatergic neurotransmission in schizophrenia by sarcosine leads to a reduction in primary negative symptoms, while its metabolic profile is safe. In order to extend research in the area, we assessed serum levels of neuropeptide Y (NPY), a hypothalamic hormone related to anxiety and depression, also involved in mechanisms inducing weight gain. Additionally, we analyzed associations between NPY concentrations and its changes with severity of symptoms and metabolic parameters.
   Methods A prospective 6-month, randomized, double-blind placebo-controlled trial was completed by 57 subjects with chronic schizophrenia with predominant negative symptoms and stable antipsychotic treatment. The participants received 2 g of sarcosine (n = 28) or placebo (n = 29) daily. We assessed serum NPY concentrations and severity of symptoms (with the Positive and Negative Syndrome Scale [PANSS] and Calgary Depression Scale for Schizophrenia) at the beginning of the study, after 6 weeks and 6 months.
   Results Sarcosine did not affect NPY levels in all time points. The highest decrease in NPY concentrations was observed in the subjects who were initially depressed, who became euthymic at the last visit. We noticed an improvement in the total PANSS score, and negative symptom and general psychopathology subscales in the sarcosine group, however, without any correlation with NPY levels.
   Conclusion The use of sarcosine does not change NPY levels. Peripheral NPY concentrations may be related to depressive symptoms in schizophrenia.
C1 [Strzelecki, Dominik; Kotlicka-Antczak, Magdalena; Kaczmarek, Bartosz] Med Univ Lodz, Dept Affect & Psychot Disorders, Lodz, Poland.
   [Jerczynska, Hanna] Med Univ Lodz, Cent Sci Lab CoreLab, Lodz, Poland.
   [Wysokinski, Adam] Med Univ Lodz, Dept Old Age Psychiat & Psychot Disorders, Lodz, Poland.
C3 Medical University Lodz; Medical University Lodz; Medical University
   Lodz
RP Strzelecki, D (corresponding author), Med Univ Lodz, Dept Affect & Psychot Disorders, Cent Clin Hosp, Ul Czechoslowacka 8-10, PL-92216 Lodz, Poland.
EM dominik.strzelecki@umed.lodz.pl
RI Strzelecki, Dominik/S-9340-2016; Wysokinski, Adam/S-9294-2016
OI Jerczynska, Hanna/0000-0001-9302-6311; Kotlicka-Antczak,
   Magdalena/0000-0001-5755-6198; Strzelecki, Dominik/0000-0002-8559-1078
FU Polish Ministry of Science and Higher Education [N402 268836]
FX Polish Ministry of Science and Higher Education, Grant/Award Number:
   N402 268836
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NR 42
TC 2
Z9 2
U1 0
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0885-6222
EI 1099-1077
J9 HUM PSYCHOPHARM CLIN
JI Hum. Psychopharmacol.-Clin. Exp.
PD MAY
PY 2021
VL 36
IS 3
DI 10.1002/hup.2770
EA NOV 2020
PG 9
WC Clinical Neurology; Pharmacology & Pharmacy; Psychiatry; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry;
   Psychology
GA RW1HJ
UT WOS:000592484800001
PM 33245168
DA 2025-06-11
ER

PT J
AU Malan, L
   Hamer, M
   Reimann, M
   Huisman, H
   Van Rooyen, J
   Schutte, A
   Schutte, R
   Potgieter, J
   Wissing, M
   Steyn, F
   Seedat, Y
   Malan, N
AF Malan, Leone
   Hamer, Mark
   Reimann, Manja
   Huisman, Hugo
   Van Rooyen, Johannes
   Schutte, Alta
   Schutte, Rudolph
   Potgieter, Johan
   Wissing, Marie
   Steyn, Faans
   Seedat, Yaackob
   Malan, Nico
TI Defensive coping, urbanization, and neuroendocrine function in Black
   Africans: The THUSA study
SO PSYCHOPHYSIOLOGY
LA English
DT Article
DE Emotion; Neurological; Normal volunteers; Blood pressure; Biochemical
ID CARDIOVASCULAR-DISEASE; PSYCHOLOGICAL STRESS; TESTOSTERONE; CORTISOL;
   HYPERTENSION; RESPONSES; RISK; HEALTH; MEN; STRATEGIES
AB Dissociation between beta-adrenergic behavioral and physiological defensive active coping (AC) responses was associated with cardiometabolic risk in urban but not rural African males. Whether this is partly driven by underlying neuroendocrine dysfunction is not certain. We aimed to assess the association between coping style, urbanization, and neuroendocrine function. Blood pressure (BP) and serum stress hormones were assessed across levels of urbanization (rural vs. urban) and coping style (active vs. passive) in 178 Black African men. Urban men demonstrated increased hypertension prevalence, a-adrenergic hemodynamic pattern, lower testosterone levels, and a larger cortisol:testosterone ratio (Cort:Test) compared to their rural counterparts. This was particularly evident in urban AC men where cortisol and Cort:Test explained 36-40% of the variance in BP. Dissociation between behavioral and physiological beta-adrenergic neuroendocrine responses in urban AC African men was shown. A stressful urban environment might induce an apparent loss of physiological control, thereby facilitating disturbed neuroendocrine AC responses, which could increase cardiovascular disease risk.
C1 [Malan, Leone; Huisman, Hugo; Van Rooyen, Johannes; Schutte, Alta; Schutte, Rudolph; Malan, Nico] North West Univ, Hypertens Africa Res Team, Sch Physiol Nutr & Consumer Sci, ZA-2520 Potchefstroom, South Africa.
   [Hamer, Mark] UCL, Dept Epidemiol & Publ Hlth, London WC1E 6BT, England.
   [Reimann, Manja] Tech Univ Dresden, Med Fac Carl Gustav Carus, Dept Neurol, Dresden, Germany.
   [Potgieter, Johan; Wissing, Marie] North West Univ, Sch Psychosocial Behav Sci, ZA-2520 Potchefstroom, South Africa.
   [Steyn, Faans] North West Univ, Stat Consultat Serv, ZA-2520 Potchefstroom, South Africa.
   [Seedat, Yaackob] Univ KwaZulu Natal, Nelson Mandela Sch Med, Renal Hypertens Unit, Durban, South Africa.
C3 North West University - South Africa; University of London; University
   College London; Technische Universitat Dresden; Carl Gustav Carus
   University Hospital; North West University - South Africa; North West
   University - South Africa; University of Kwazulu Natal
RP Malan, L (corresponding author), North West Univ, Hypertens Africa Res Team, Sch Physiol Nutr & Consumer Sci, Potchefstroom Campus,Private Bag X6001, ZA-2520 Potchefstroom, South Africa.
EM leone.malan@nwu.ac.za
RI Wissing, Maria alias Marié alias M P/JOK-1968-2023; Malan,
   Leone/Q-8187-2019; Schneider, Ione/J-8762-2013; Malan,
   Leone/D-7203-2014; Hamer, Mark/C-1602-2008; Schutte, Aletta/E-5126-2018
OI Malan, Leone/0000-0003-3187-2410; Hamer, Mark/0000-0002-8726-7992;
   Schutte, Aletta/0000-0001-9217-4937; Huisman, Hugo/0000-0002-2114-4789
FU National Research Foundation; Medical Research Council; South African
   Sugar Association; Dry Bean Producers in South Africa; Clover Industries
   Limited; North-West University (Potchefstroom Campus); African Unit for
   Trans-Disciplinary Health Research
FX This work was supported by the National Research Foundation, the Medical
   Research Council, the South African Sugar Association, Dry Bean
   Producers in South Africa, Clover Industries Limited, and from the
   North-West University (Potchefstroom Campus) and the African Unit for
   Trans-Disciplinary Health Research. The THUSA Study would not have been
   possible without the voluntary collaboration of the participants.
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NR 48
TC 8
Z9 9
U1 0
U2 13
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0048-5772
J9 PSYCHOPHYSIOLOGY
JI Psychophysiology
PD JUN
PY 2012
VL 49
IS 6
BP 807
EP 814
DI 10.1111/j.1469-8986.2012.01362.x
PG 8
WC Psychology, Biological; Neurosciences; Physiology; Psychology;
   Psychology, Experimental
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Neurosciences & Neurology; Physiology
GA 935DC
UT WOS:000303498100007
PM 22416967
DA 2025-06-11
ER

PT J
AU Chung, G
   Kim, HJ
AF Chung, Goeun
   Kim, Hye-Jin
TI Lifestyle and Health Behaviors Associated with Metabolic Syndrome and
   Cardiovascular Disease
SO METABOLIC SYNDROME AND RELATED DISORDERS
LA English
DT Article
DE lifestyle; health behavior; metabolic syndrome; myocardial infarction;
   stroke; cardiovascular disease
ID CHRONIC HEART-FAILURE; 3RD NATIONAL-HEALTH; RISK-FACTOR; PREVALENCE;
   METAANALYSIS; MORTALITY; EXERCISE
AB Background: As the prevalence of cardiovascular disease increases, the socioeconomic burden is expected to increase further. This study aimed to investigate lifestyle and health behaviors related to metabolic syndrome (MetS), myocardial infarction (MI), and stroke prevalence in men and women 50-79 years of age to assess clustering of risk factors.Methods: This study used raw data from the eighth Korea National Health and Nutrition Examination Survey (KNHANES) in 2021. Collected data were analyzed using SPSS 29.0 program. Complex Samples General Linear Model procedure and Complex Samples Logistic Regression procedure were performed.Results: Body mass index of more than 25.0 kg/m2, being a woman, having a middle school education or less, reporting a lower middle economic status, and performing exercise for less than 150 min a week were associated with MetS prevalence. Stress was associated with MI prevalence in men and women. Depression was associated with stroke prevalence in men.Conclusions: This study found that an education on obesity control in men and women is needed to reduce the prevalence of MetS. To reduce the prevalence of MI, stress management is required for men and women. To decrease stroke prevalence, depression management is needed for men.
C1 [Chung, Goeun] Jeju Natl Univ Hosp, Dept Publ Hlth Med Serv, Jeju, South Korea.
   [Kim, Hye-Jin] Univ Ulsan, Coll Med, Dept Nursing, Ulsan, South Korea.
   [Chung, Goeun] Chungnam Natl Univ Hosp, Reg Cardio Cerebrovascular Ctr, Daejeon, South Korea.
   [Kim, Hye-Jin] Coll Med Univ Ulsan, Dept Nursing, 93 Daehak Ro, Ulsan 44610, South Korea.
C3 Jeju National University; University of Ulsan; Chungnam National
   University; Chungnam National University Hospital
RP Kim, HJ (corresponding author), Coll Med Univ Ulsan, Dept Nursing, 93 Daehak Ro, Ulsan 44610, South Korea.
EM kk02khj@ulsan.ac.kr
OI Kim, Hye-Jin/0000-0001-7088-2692; Chung, Goeun/0000-0003-1021-016X
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NR 40
TC 0
Z9 0
U1 3
U2 6
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-4196
EI 1557-8518
J9 METAB SYNDR RELAT D
JI Metab. Syndr. Relat. Disord.
PD MAR 1
PY 2024
VL 22
IS 2
BP 105
EP 113
DI 10.1089/met.2023.0152
EA NOV 2023
PG 9
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA LJ5W4
UT WOS:001140182200001
PM 38011536
DA 2025-06-11
ER

PT J
AU Holvoet, P
   De Keyzer, D
   Jacobs, DR
AF Holvoet, Paul
   De Keyzer, Dieuwke
   Jacobs, David R., Jr.
TI Oxidized LDL and the metabolic syndrome
SO FUTURE LIPIDOLOGY
LA English
DT Review
DE atherosclerosis; inflammation; metabolic syndrome; obesity; oxidative
   stress; oxidized LDL
ID LOW-DENSITY-LIPOPROTEIN; CORONARY-HEART-DISEASE; C-REACTIVE PROTEIN;
   CARDIOVASCULAR RISK-FACTORS; COA REDUCTASE INHIBITORS; BODY-MASS-INDEX;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; WEIGHT-LOSS; ABDOMINAL OBESITY
AB The metabolic syndrome is a common and complex disorder combining obesity, dyslipidemia, hypertension and insulin resistance. It is associated with a high cardiovascular risk that can only partially be explained by its components. There is evidence that low-grade inflammation and high oxidative stress add to this risk. Oxidized LDL, a marker of lipoprotein-associated oxidative stress, is an emerging cardiovascular risk factor. In this review, we demonstrate that the metabolic syndrome exacerbates oxidized LDL in a feedback loop, We introduce molecular mechanisms underlying this loop. Finally, we demonstrate that weight loss and statin treatment lower metabolic syndrome factors associated with a reduction of oxidized LDL. The current data warrant further investigation into the role of lifestyle and therapeutic interventions that inhibit tissue-associated oxidation of LDL in the prevention of the metabolic syndrome.
C1 [Holvoet, Paul; De Keyzer, Dieuwke] Katholieke Univ Leuven, Dept Cardiovasc Dis, Atherosclerosis & Metab Unit, B-3000 Louvain, Belgium.
   [Jacobs, David R., Jr.] Univ Minnesota, Div Epidemiol & Community Hlth, Minneapolis, MN 55454 USA.
C3 KU Leuven; University of Minnesota System; University of Minnesota Twin
   Cities
RP Holvoet, P (corresponding author), Katholieke Univ Leuven, Dept Cardiovasc Dis, Atherosclerosis & Metab Unit, Herestr 49, B-3000 Louvain, Belgium.
EM paul.holvoet@med.kuleuven.be; Dieuwke.DeKeyzer@med.kuleuven.be;
   jacob004@umn.edu
RI Jacobs, David/G-5405-2011; HOLVOET, PAUL/T-8434-2017
OI Jacobs, David/0000-0002-7232-0543
FU NHLBI NIH HHS [R01 HL053560] Funding Source: Medline
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NR 98
TC 87
Z9 102
U1 0
U2 8
PU FUTURE MEDICINE LTD
PI LONDON
PA UNITEC HOUSE, 3RD FLOOR, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON, N3
   1QB, ENGLAND
SN 1746-0875
J9 FUTURE LIPIDOL
JI Future Lipidol.
PD DEC
PY 2008
VL 3
IS 6
BP 637
EP 649
DI 10.2217/17460875.3.6.637
PG 13
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 381WJ
UT WOS:000261566300010
PM 19802339
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Das, SK
   Mason, ST
   Vail, TA
   Rogers, GV
   Livingston, KA
   Whelan, JG
   Chin, MK
   Blanchard, CM
   Turgiss, JL
   Roberts, SB
AF Das, Sai Krupa
   Mason, Shawn T.
   Vail, Taylor A.
   Rogers, Gail, V
   Livingston, Kara A.
   Whelan, Jillian G.
   Chin, Meghan K.
   Blanchard, Caroline M.
   Turgiss, Jennifer L.
   Roberts, Susan B.
TI Effectiveness of an Energy Management Training Course on Employee
   Well-Being: A Randomized Controlled Trial
SO AMERICAN JOURNAL OF HEALTH PROMOTION
LA English
DT Article
DE employee wellness program; well-being intervention; behavior change
   intervention; quality of life; purpose in life
ID POSITIVE PSYCHOLOGY INTERVENTIONS; ALZHEIMER-DISEASE; LIFE; PURPOSE;
   HEALTH; VITALITY; STRESS
AB Purpose: Programs focused on employee well-being have gained momentum in recent years, but few have been rigorously evaluated. This study evaluates the effectiveness of an intervention designed to enhance vitality and purpose in life by assessing changes in employee quality of life (QoL) and health-related behaviors. Design: A worksite-based randomized controlled trial. Setting: Twelve eligible worksites (8 randomized to the intervention group [IG] and 4 to the wait-listed control group [CG]). Participants: Employees (n = 240) at the randomized worksites. Intervention: A 2.5-day group-based behavioral intervention. Measures: Rand Medical Outcomes Survey (MOS) 36-item Short-Form (SF-36) vitality and QoL measures, Ryff Purpose in Life Scale, Center for Epidemiologic Studies questionnaire for depression, MOS sleep, body weight, physical activity, diet quality, and blood measures for glucose and lipids (which were used to calculate a cardiometabolic risk score) obtained at baseline and 6 months. Analysis: General linear mixed models were used to compare least squares means or prevalence differences in outcomes between IG and CG participants. Results: As compared to CG, IG had a significantly higher mean 6-month change on the SF-36 vitality scale (P = .003) and scored in the highest categories for 5 of the remaining 7 SF-36 domains: general health (P = .014), mental health (P = .027), absence of role limitations due to physical problems (P = .026), and social functioning (P = .007). The IG also had greater improvements in purpose in life (P < .001) and sleep quality (index I, P = .024; index II, P = .021). No statistically significant changes were observed for weight, diet, physical activity, or cardiometabolic risk factors. Conclusion: An intensive 2.5-day intervention showed improvement in employee QoL and well-being over 6 months.
C1 [Das, Sai Krupa; Vail, Taylor A.; Rogers, Gail, V; Livingston, Kara A.; Whelan, Jillian G.; Chin, Meghan K.; Blanchard, Caroline M.; Roberts, Susan B.] Tufts Univ, Jean Mayer USDA, Human Nutr Res Ctr Aging, Boston, MA 02111 USA.
   [Mason, Shawn T.; Turgiss, Jennifer L.] Hlth & Wellness Solut Inc, Johnson & Johnson, New Brunswick, NJ USA.
C3 United States Department of Agriculture (USDA); Tufts University;
   Johnson & Johnson; Johnson & Johnson USA
RP Das, SK (corresponding author), Tufts Univ, Jean Mayer USDA, Human Nutr Res Ctr Aging, Boston, MA 02111 USA.
EM sai.das@tufts.edu
OI Livingston Staffier, Kara/0000-0003-0998-1178; Roberts,
   Susan/0000-0003-1320-8460
FU Johnson & Johnson, Health and Wellness Solutions, Inc.
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: Funding
   was provided to Tufts University by Johnson & Johnson, Health and
   Wellness Solutions, Inc.
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NR 43
TC 12
Z9 14
U1 0
U2 15
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0890-1171
EI 2168-6602
J9 AM J HEALTH PROMOT
JI Am. J. Health Promot.
PD JAN
PY 2019
VL 33
IS 1
BP 118
EP 130
DI 10.1177/0890117118776875
PG 13
WC Public, Environmental & Occupational Health
WE Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA HI4YA
UT WOS:000456457200013
PM 29807441
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Emeny, R
   Lacruz, ME
   Baumert, J
   Zierer, A
   Rothe, AV
   Autenrieth, C
   Herder, C
   Koenig, W
   Thorand, B
   Ladwig, KH
AF Emeny, Rebecca
   Lacruz, Marie-Elena
   Baumert, Jens
   Zierer, Astrid
   Rothe, Alexander von Eisenhart
   Autenrieth, Christine
   Herder, Christian
   Koenig, Wolfgang
   Thorand, Barbara
   Ladwig, Karl-Heinz
CA KORA Study Investigators
TI Job strain associated CRP is mediated by leisure time physical activity:
   Results from the MONICA/KORA study
SO BRAIN BEHAVIOR AND IMMUNITY
LA English
DT Article
DE Stress; Inflammation; CRP; Job strain; Work stress; Physical activity;
   Coronary heart disease
ID CORONARY-HEART-DISEASE; C-REACTIVE PROTEIN; TYPE-2 DIABETES-MELLITUS;
   AUGSBURG CASE-COHORT; MIDDLE-AGED MEN; DECISION LATITUDE; RISK-FACTORS;
   WORK STRESS; MYOCARDIAL-INFARCTION; WOMEN
AB Background: Psychological stress at work is considered a cardiac risk factor, yet whether it acts directly through neuroimmune processes, or indirectly by increasing behavioral risk factors, is uncertain. Cross-sectional associations between job strain and serum biomarkers of inflammation and endothelial dysfunction were investigated. Secondary analyses explored the role of psychosocial/cardiometabolic risk factors as mediators of job stress associated inflammation in healthy workers.
   Methods: Information on risk factors was obtained in standardized personal interviews of a subcohort of working participants in the MONICA/KORA population (n = 951). Work stress was measured by the Karasek job strain index. Biomarkers were measured from non-fasting venous blood. Multivariate regression analyses were used to examine the association of job strain with inflammatory biomarkers. Mediation analysis (Sobel test) was used to determine the effect of psychosocial risk factors on the association between job strain and C-reactive protein (CRP).
   Results: High job strain was reported by half (n = 482, 50.7%) of the study participants. While workers with high job strain were more likely to have adverse workplace conditions (competition with coworkers, job dissatisfaction and insecurity), sleeping problems, depressive symptoms, a Type A personality, and be physically inactive, no differences in cardiometabolic risk factors were detected. A strong and robust association between job strain and CRP was observed in age and sex adjusted models, as well as models adjusted for classic coronary heart disease risk factors (beta = 0.39, p = 0.006 and beta = 0.27, p = 0.03, respectively). Adjustment for physical activity abrogated this effect (beta = 0.23, p = 0.07), and a mediating effect of physical activity on stress-associated inflammation was demonstrated (p = 0.04).
   Conclusions: The analyses provide evidence for both a direct and an indirect effect of job strain on inflammation. (c) 2012 Elsevier Inc. All rights reserved.
C1 [Emeny, Rebecca; Lacruz, Marie-Elena; Baumert, Jens; Zierer, Astrid; Rothe, Alexander von Eisenhart; Autenrieth, Christine; Thorand, Barbara; Ladwig, Karl-Heinz] German Res Ctr Environm Hlth, Helmholtz Zentrum Muenchen, Inst Epidemiol 2, D-85764 Neuherberg, Germany.
   [Herder, Christian] Univ Dusseldorf, Leibniz Ctr Diabet Res, German Diabet Ctr, Inst Clin Diabetol, D-40225 Dusseldorf, Germany.
   [Koenig, Wolfgang] Univ Ulm, Med Ctr, Dept Internal Med Cardiol 2, D-89081 Ulm, Germany.
   [Ladwig, Karl-Heinz] Tech Univ Munich, Klinikum Rechts Isar, Dept Psychosomat Med & Psychotherapy, D-81644 Munich, Germany.
C3 Helmholtz Association; Helmholtz-Center Munich - German Research Center
   for Environmental Health; Leibniz Association; Deutsches
   Diabetes-Zentrum (DDZ); Heinrich Heine University Dusseldorf; Ulm
   University; Technical University of Munich
RP Ladwig, KH (corresponding author), German Res Ctr Environm Hlth, Helmholtz Zentrum Muenchen, Inst Epidemiol 2, Ingolstaedter Landstr 1, D-85764 Neuherberg, Germany.
EM ladwig@helmholtz-muenchen.de
RI Koenig, Wolfgang/JCF-0788-2023; Lacruz, Maria/KHV-7908-2024; Ladwig,
   Karl-Heinz/B-5351-2014; Emeny, Rebecca/I-1100-2014; Thorand,
   Barbara/B-5349-2014; von Eisenhart Rothe, Alexander/N-6226-2014
OI Koenig, Wolfgang/0000-0002-2064-9603; Lacruz, Maria
   Elena/0000-0003-2036-3039; von Eisenhart Rothe,
   Alexander/0000-0002-8397-8404
FU GSF - National Research Center for Environment and Health, Neuherberg,
   Germany (now Helmholtz Zentrum Munchen, German Research Center for
   Environmental Health); German Federal Ministry of Education, Science,
   Research and Technology; State of Bavaria; German Research Foundation
   [TH-784/2-1, TH-784/2-2]; European Foundation for the Study of Diabetes;
   Federal Ministry of Health (Berlin, Germany); Ministry of Innovation,
   Science, Research and Technology of the state North Rhine-Westphalia
   (Dusseldorf, Germany); University of Ulm, Germany; German Diabetes
   Center
FX The MONICA/KORA Augsburg studies were initiated and financed by the GSF
   - National Research Center for Environment and Health, Neuherberg,
   Germany (now Helmholtz Zentrum Munchen, German Research Center for
   Environmental Health) and the German Federal Ministry of Education,
   Science, Research and Technology and by the State of Bavaria. Additional
   support was provided from the German Research Foundation (TH-784/2-1 and
   TH-784/2-2) the European Foundation for the Study of Diabetes, the
   Federal Ministry of Health (Berlin, Germany), the Ministry of
   Innovation, Science, Research and Technology of the state North
   Rhine-Westphalia (Dusseldorf, Germany), and by additional funds provided
   by the University of Ulm, Germany and the German Diabetes Center.
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NR 52
TC 36
Z9 38
U1 1
U2 26
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0889-1591
EI 1090-2139
J9 BRAIN BEHAV IMMUN
JI Brain Behav. Immun.
PD OCT
PY 2012
VL 26
IS 7
BP 1077
EP 1084
DI 10.1016/j.bbi.2012.07.004
PG 8
WC Immunology; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Immunology; Neurosciences & Neurology; Psychiatry
GA 007PC
UT WOS:000308899600010
PM 22813435
DA 2025-06-11
ER

PT J
AU Lee, HS
   Park, E
AF Lee, Hea Shoon
   Park, Eunmi
TI Association of serum ferritin level and depression with respect to the
   body mass index in Korean male adults
SO NUTRITION RESEARCH AND PRACTICE
LA English
DT Article
DE BMI; obesity; ferritins; depression
ID METABOLIC SYNDROME; NATIONAL-HEALTH; OBESITY; MEN; PREVALENCE;
   OVERWEIGHT; ANXIETY; IRON; RISK
AB BACKGROUD/OBJECTIVES: Obesity is globally a major public health issue. Evidence suggests that elevated ferritin levels are associated with obesity, dyslipidemia, insulin resistance, and metabolic syndrome. This study was undertaken to examine the relationship between the serum ferritin level and depression in Korean male adults with respect to classification of the prevailing obesity.
   SUBJECTS/METHODS: This was a case-control study; subjects were classified into obese group (>= 25.0 kg/m(2), 28 subjects) and normal group (18.5-22.9 kg/m(2), 27 subjects). A survey was conducted to assess the depression levels as per the guidelines suggested by the Center program for Epidemiological Studies-Depression (CES-D). Blood was collected from each group for assessing biomarkers, and isolated plasma was evaluated for fasting glucose, insulin, quantitative insulin sensitivity check index, and ferritin levels. Data were analyzed, and groups were compared with respect to Body Mass Index (BMI), depression scale and biomarkers.
   RESULTS: The average depression score of the obesity group was 16.86, which was higher than the normal group (12.56). Subjects scoring more than 16 points comprised 53.6% of the population in the obese group, which was more than double that in the normal group, as assessed by the CES-D program. Furthermore, the serum ferritin level of the obesity group was 207.12 ng/mL, which was higher than that of the normal group (132.66 ng/mL). Lastly, the BMI appeared to be significantly correlated with both depression (r = 0.320, P = 0.017) and elevated ferritin levels (r = 0.352, P = 0.008).
   CONCLUSION: This study provides evidence of existing correlation between ferritin and depression with obesity.
C1 [Lee, Hea Shoon] Hannam Univ, Dept Nursing, Daejeon 34054, South Korea.
   [Park, Eunmi] Hannam Univ, Sch Life Sci & Nanotechnol, Dept Food & Nutr, Daejeon 34054, South Korea.
C3 Hannam University; Hannam University
RP Park, E (corresponding author), Hannam Univ, Sch Life Sci & Nanotechnol, Dept Food & Nutr, Daejeon 34054, South Korea.
EM eunmi_park@hnu.kr
FU Basic Science Research Program through the National Research of Korea
   (NRF) - Ministry of Science, ICT & Future Planning [2015R1C1A1A02037579]
FX This study was supported by the Basic Science Research Program through
   the National Research of Korea (NRF) funded by the Ministry of Science,
   ICT & Future Planning (Grant No. 2015R1C1A1A02037579).
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NR 33
TC 8
Z9 9
U1 0
U2 5
PU KOREAN NUTRITION SOC
PI SEOUL
PA 804 KST CTR, 635-4 YEOGSAM-SONG KANGNAM-KU, SEOUL, 135-703, SOUTH KOREA
SN 1976-1457
EI 2005-6168
J9 NUTR RES PRACT
JI Nutr. Res. Pract.
PD JUN
PY 2019
VL 13
IS 3
BP 263
EP 267
DI 10.4162/nrp.2019.13.3.263
PG 5
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA ID0EV
UT WOS:000471357400010
PM 31214295
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Coakley, C
   Bolton, P
   Flaherty, L
   Kopeski, LM
   Slifka, K
   Sutherland, MA
AF Coakley, Catherine
   Bolton, Paula
   Flaherty, Linda
   Kopeski, Lynne M.
   Slifka, Karen
   Sutherland, Melissa A.
TI The Incidence of Metabolic Risk Factors in an Inpatient Psychiatric
   Setting
SO JOURNAL OF PSYCHOSOCIAL NURSING AND MENTAL HEALTH SERVICES
LA English
DT Article
ID MENTAL-HEALTH-CARE; MEDICAL-SERVICES; SCHIZOPHRENIA; DISORDERS; ACCESS
AB Our study examines risk factors for metabolic syndrome on admission to an acute psychiatric facility and the incidence of medical referrals at discharge. Data on demographics, risk factors for metabolic syndrome, other health risk factors, medications, related diagnoses, and primary care providers and referrals were collected from 125 psychiatric patient charts. Comparison analysis was done for two groups: those with two or more risk factors for metabolic syndrome and those with less than two risk factors. Differences between groups were statistically significant for age, waist circumference, body mass index, high-density lipoprotein, triglycerides, and fasting glucose levels. Few patients were referred to their primary care provider for follow-up care. This study has clinical implications for improving assessment of psychiatric patients at risk for developing metabolic syndrome, for designing interventions to help patients adopt lifestyle changes to mitigate these risks, and for working toward fuller integration of psychiatric and primary care.
C1 [Coakley, Catherine] McLean Hosp, Schizophrenia & Bipolar Disorders Program, Belmont, MA 02178 USA.
   [Bolton, Paula] McLean Hosp, Dept Internal Med, Belmont, MA 02178 USA.
   [Kopeski, Lynne M.] McLean Hosp, Behav Hlth Partial Hosp Program, Belmont, MA 02178 USA.
   [Sutherland, Melissa A.] Boston Coll, William F Connell Sch Nursing, Chestnut Hill, MA 02467 USA.
C3 Harvard University; Harvard University Medical Affiliates; McLean
   Hospital; Harvard University; Harvard University Medical Affiliates;
   McLean Hospital; Harvard University; Harvard University Medical
   Affiliates; McLean Hospital; Boston College
RP Sutherland, MA (corresponding author), Boston Coll, William F Connell Sch Nursing, 140 Commonwealth Ave, Chestnut Hill, MA 02467 USA.
EM Melissa.Sutherland@bc.edu
OI Sutherland, Melissa/0000-0002-0242-2536
FU Pollinator Trust
FX Ms. Coakley, Ms. Bolton, Ms. Flaherty, Ms. Slifka, and Dr. Sutherland
   disclose that they have no significant financial interests in any
   product or class of products discussed directly or indirectly in this
   activity. Ms. Kopeski discloses that she is a Johnson & Johnson, Inc.
   shareholder. This study was supported by the Pollinator Trust Fund,
   which supports professional development, education, and training for
   RNs. A key initiative has been the Visiting Scholar Program, which has
   advanced the ability of nursing staff to conduct clinically based
   research. Dr. Sutherland served as the first Nurse Scholar in Residence
   at McLean Hospital.
CR [Anonymous], MORB MORT PEOPL SER
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NR 24
TC 6
Z9 6
U1 0
U2 2
PU SLACK INC
PI THOROFARE
PA 6900 GROVE RD, THOROFARE, NJ 08086 USA
SN 0279-3695
J9 J PSYCHOSOC NURS MEN
JI J. Psychosoc. Nurs. Ment. Health Serv.
PD MAR
PY 2012
VL 50
IS 3
BP 24
EP 30
DI 10.3928/02793695-20120207-01
PG 7
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA 905VA
UT WOS:000301302800010
PM 22329619
DA 2025-06-11
ER

PT J
AU Happell, B
   Platania-Phung, C
   Scott, D
   Stanton, R
AF Happell, Brenda
   Platania-Phung, Chris
   Scott, David
   Stanton, Robert
TI Predictors of Nurse Support for the Introduction of the Cardiometabolic
   Health Nurse in the Australian Mental Health Sector
SO PERSPECTIVES IN PSYCHIATRIC CARE
LA English
DT Article
DE Cardiometabolic health nurse; cardiovascular disease; diabetes care;
   mental health care; serious mental illness
ID MEDICAL-CARE MANAGEMENT; PHYSICAL HEALTH; METABOLIC SYNDROME; ILLNESS;
   PEOPLE; NEEDS; SCHIZOPHRENIA; VIEWS; INTERVENTIONS; PROVISION
AB PurposeA cardiometabolic specialist nursing role could potentially improve physical health of people with serious mental illness.
   Design and MethodsA national survey of Australian nurses working in mental health settings investigated predictors of support for the role.
   FindingsPredictors included belief in physical healthcare neglect, interest in training; higher perceived value of improving physical health care.
   Practice ImplicationsThe findings suggest that nurses see the cardiometabolic health nurse role as a promising initiative for closing gaps in cardiometabolic health care and skilling other nurses in mental health. However, as the majority of variance in cardiometabolic health nurse support was unexplained, more research is urgently needed on factors that explain differences in cardiometabolic health nurse endorsement.
C1 [Happell, Brenda] Cent Queensland Univ, Mental Hlth Nursing, Rockhampton, Qld 4702, Australia.
   [Happell, Brenda; Platania-Phung, Chris; Scott, David; Stanton, Robert] Cent Queensland Univ, Ctr Mental Hlth Nursing Innovat, Inst Hlth & Social Sci Res, Rockhampton, Qld 4702, Australia.
   [Happell, Brenda; Platania-Phung, Chris; Scott, David; Stanton, Robert] Cent Queensland Univ, Sch Nursing & Midwifery, Rockhampton, Qld 4702, Australia.
C3 Central Queensland University; Central Queensland University; Central
   Queensland University
RP Happell, B (corresponding author), Cent Queensland Univ, Mental Hlth Nursing, Rockhampton, Qld 4702, Australia.
EM b.happell@cqu.edu.au
RI Scott, David/AAE-5031-2021; Stanton, Rob/AAJ-5157-2020; Happell,
   Brenda/HSI-0570-2023
OI Happell, Brenda/0000-0002-7293-6583; Scott, David/0000-0001-5226-1972
FU Central Queensland University
FX Research Advancement Award Scheme and Merit Grant Scheme of Central
   Queensland University provided the funding to make this work possible.
CR Ahire M, 2013, AUST NZ J PSYCHIAT, V47, P177, DOI 10.1177/0004867412450753
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NR 44
TC 5
Z9 5
U1 0
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0031-5990
EI 1744-6163
J9 PERSPECT PSYCHIATR C
JI Perspect. Psychiatr. Care
PD JUL
PY 2015
VL 51
IS 3
BP 162
EP 170
DI 10.1111/ppc.12077
PG 9
WC Nursing; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Psychiatry
GA CM9GW
UT WOS:000358016700003
PM 24957751
DA 2025-06-11
ER

PT J
AU Nebhinani, N
   Sharma, P
   Suthar, N
   Pareek, V
   Kunwar, D
   Purohit, P
   Purohit, P
AF Nebhinani, Naresh
   Sharma, Praveen
   Suthar, Navratan
   Pareek, Vrinda
   Kunwar, Deep
   Purohit, Priyanka
   Purohit, Purvi
TI Correlates of metabolic syndrome in patients with depression: A study
   from north-western India
SO DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS
LA English
DT Article
DE Metabolic syndrome; Metabolic abnormalities; Physical activity;
   Nutritional habits; Lifestyle factors; Depression
ID PHYSICAL-ACTIVITY; DISORDER; METAANALYSIS; ASSOCIATION; PREVALENCE;
   PEOPLE; ADULTS; HEALTH; YOUNG; RISK
AB Background and Aims: Metabolic syndrome (MS) is found to be prevalent in patients with mental illness including depression. Data is sparse on the role of lifestyle factors on MS in depression.
   Methods: This study was aimed to assess correlates of MS in patients with depression. Methodology: Three hundred eighty-two patients with depressive disorders were assessed for the prevalence of MS by using modified National Cholesterol Education Program- Adult Treatment Panel-III criteria (NCEP ATP-III). Their illness severity, functionality, physical activity and nutritional habits were also assessed.
   Conclusions: Majority of patients with depression (82.2%) were drug naive. One-fourth of the patients had metabolic syndrome (27.7%). Additionally, other 59% of patients had one or two metabolic abnormalities and one-third of patients were obese. Lower high density lipoprotein cholesterol level was the most common abnormality (65%), while abnormal blood pressure was the least common abnormality (18%). Significant correlates of MS were greater age, and age at onset of depression, greater illness duration, lesser physical activity and lower nutritional score.
   Conclusion: Nearly one-fourth of patients with depression had MS; another three-fifth of patients had one or two metabolic abnormalities. MS was more commonly seen with sedentary lifestyle and poor nutritional habits. It calls for comprehensive assessment and timely management of cardiovascular risk factors as well as lifestyle factors in depression. (C) 2020 Diabetes India. Published by Elsevier Ltd. All rights reserved.
C1 [Nebhinani, Naresh; Suthar, Navratan; Kunwar, Deep; Purohit, Priyanka] All India Inst Med Sci, Dept Psychiat, Jodhpur, Rajasthan, India.
   [Sharma, Praveen; Purohit, Purvi] All India Inst Med Sci, Dept Biochem, Jodhpur, Rajasthan, India.
   [Pareek, Vrinda] Govt Med Coll, Dept Psychiat, Vadodara, Gujarat, India.
C3 All India Institute of Medical Sciences (AIIMS) Jodhpur; All India
   Institute of Medical Sciences (AIIMS) Jodhpur
RP Nebhinani, N (corresponding author), All India Inst Med Sci, Dept Psychiat, Jodhpur, Rajasthan, India.
EM drnaresh_pgi@yahoo.com
RI purohit, purvi/F-6066-2011; Sharma, Praveen/AAR-7750-2021
OI Sharma, Praveen/0000-0002-8324-737X; PUROHIT, PURVI/0000-0001-8559-2911
FU All India Institute of Medical Sciences (AIIMS), Jodhpur, Rajasthan
   [AIIMS/IEC/2014/0000035]
FX This project has received intramural grant (Ref No.
   AIIMS/IEC/2014/0000035) from All India Institute of Medical Sciences
   (AIIMS), Jodhpur, Rajasthan.
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NR 30
TC 6
Z9 6
U1 0
U2 1
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 1871-4021
EI 1878-0334
J9 DIAB MET SYND CLIN R
JI DIABET. METAB. SYNDR. CLIN. RES. REV.
PD NOV-DEC
PY 2020
VL 14
IS 6
BP 1997
EP 2002
DI 10.1016/j.dsx.2020.10.013
PG 6
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA PO7TE
UT WOS:000605370300080
PM 33080542
DA 2025-06-11
ER

PT S
AU Rinaudo, P
   Wang, E
AF Rinaudo, Paolo
   Wang, Erica
BE Julius, D
   Clapham, DE
TI Fetal Programming and Metabolic Syndrome
SO ANNUAL REVIEW OF PHYSIOLOGY, VOL 74
SE Annual Review of Physiology
LA English
DT Review; Book Chapter
DE nutrition; developmental-origin-of-health-and-disease hypothesis; in
   utero stress
ID INTRAUTERINE GROWTH-RETARDATION; IN-VITRO FERTILIZATION; LOW-PROTEIN
   DIET; SYSTOLIC BLOOD-PRESSURE; CORONARY-HEART-DISEASE; BODY-MASS INDEX;
   COACTIVATOR-1 GENE-EXPRESSION; LONG-TERM CONSEQUENCES; LOW-BIRTH-WEIGHT;
   CARDIOVASCULAR-DISEASE
AB Metabolic syndrome is reaching epidemic proportions, particularly in developing countries. In this review, we explore the concept-based on the developmental-origin-of-health-and-disease hypothesis-that reprogramming during critical times of fetal life can lead to metabolic syndrome in adulthood. Specifically, we summarize the epidemiological evidence linking prenatal stress, manifested by low birth weight, to metabolic syndrome and its individual components. We also review animal studies that suggest potential mechanisms for the long-term effects of fetal reprogramming, including the cellular response to stress and both organ- and hormone-specific alterations induced by stress. Although metabolic syndrome in adulthood is undoubtedly caused by multiple factors, including modifiable behavior, fetal life may provide a critical window in which individuals are predisposed to metabolic syndrome later in life.
C1 [Rinaudo, Paolo; Wang, Erica] Univ Calif San Francisco, Dept Obstet Gynecol & Reprod Sci, Div Reprod Endocrinol & Infertil, San Francisco, CA 94115 USA.
   [Rinaudo, Paolo] Univ Calif San Francisco, Eli & Edythe Broad Ctr Regenerat Med & Stem Cell, San Francisco, CA 94143 USA.
C3 University of California System; University of California San Francisco;
   University of California System; University of California San Francisco
RP Rinaudo, P (corresponding author), Univ Calif San Francisco, Dept Obstet Gynecol & Reprod Sci, Div Reprod Endocrinol & Infertil, San Francisco, CA 94115 USA.
EM rinaudop@obgyn.ucsf.edu
FU NICHD NIH HHS [R01 HD062803, R01 HD062803-02] Funding Source: Medline
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NR 149
TC 201
Z9 224
U1 1
U2 43
PU ANNUAL REVIEWS
PI PALO ALTO
PA 4139 EL CAMINO WAY, PO BOX 10139, PALO ALTO, CA 94303-0897 USA
SN 0066-4278
EI 1545-1585
BN 978-0-8243-0374-7
J9 ANNU REV PHYSIOL
JI Annu. Rev. Physiol.
PY 2012
VL 74
BP 107
EP 130
DI 10.1146/annurev-physiol-020911-153245
PG 24
WC Physiology
WE Book Citation Index – Science (BKCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA BZJ96
UT WOS:000301794000006
PM 21910625
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Cotter, EW
   Kelly, NR
AF Cotter, Elizabeth W.
   Kelly, Nichole R.
TI Stress-Related Eating, Mindfulness, and Obesity
SO HEALTH PSYCHOLOGY
LA English
DT Article
DE adults; eating; mindfulness; obesity; stress
ID BODY-MASS INDEX; PSYCHOLOGICAL STRESS; WEIGHT-LOSS; DISPOSITIONAL
   MINDFULNESS; PSYCHOSOCIAL STRESS; EMOTION REGULATION; METABOLIC
   SYNDROME; INDUCED CORTISOL; UNITED-STATES; DAILY HASSLES
AB Objective: This study explored how experiences of stress in adulthood, including the occurrence of stressful life events and psychosocial strains in various life domains, might be related to stress-related eating and indicators of obesity, including body mass index (BMI) and waist circumference. Method: Cross-sectional data were examined from 3,708 adults in the Midlife in the U.S. study (MIDUS II). Results: Hierarchical regression analyses indicated that experiences of stress were associated with higher BMI and waist circumference, even after controlling for age, annual household income, education level, race, and sex, although the additional variance accounted for was small. A nonparametric bootstrapping approach indicated that stress-related eating mediated the association between experiences of stress and indicators of obesity. Moderated-mediation analyses indicated that the relationship between experiences of stress and stress-related eating was amplified for women and individuals with obesity in comparison to men and individuals without obesity. Mindfulness did not moderate the experiences of stress and stress-related eating association. Conclusions: These results provide further evidence of the contributions of psychosocial factors to chronic disease risk.
C1 [Cotter, Elizabeth W.] Amer Univ, Dept Hlth Studies, 4400 Massachusetts Ave NW, Washington, DC 20016 USA.
   [Kelly, Nichole R.] Univ Oregon, Coll Educ, Prevent Sci Inst, Eugene, OR 97403 USA.
C3 American University; University of Oregon
RP Cotter, EW (corresponding author), Amer Univ, Dept Hlth Studies, 4400 Massachusetts Ave NW, Washington, DC 20016 USA.
EM cotter@american.edu
OI Kelly, Nichole/0000-0003-0812-4182
FU NIA NIH HHS [P01 AG020166, U19 AG051426] Funding Source: Medline
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NR 87
TC 60
Z9 72
U1 6
U2 85
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 0278-6133
EI 1930-7810
J9 HEALTH PSYCHOL
JI Health Psychol.
PD JUN
PY 2018
VL 37
IS 6
BP 516
EP 525
DI 10.1037/hea0000614
PG 10
WC Psychology, Clinical; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology
GA GG5DK
UT WOS:000432715300002
PM 29708389
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Darenskaya, MA
   Belenkaya, LV
   Atalyan, AV
   Danusevich, IN
   Lazareva, LM
   Nadelyaeva, YG
   Kolesnikova, LI
AF Darenskaya, M. A.
   Belenkaya, L. V.
   Atalyan, A. V.
   Danusevich, I. N.
   Lazareva, L. M.
   Nadelyaeva, Ya. G.
   Kolesnikova, L. I.
TI Oxidative Stress Reactions in Women of Reproductive Age with Metabolic
   Syndrome
SO BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
LA English
DT Article
DE metabolic syndrome; oxidative stress; women; reproductive age
ID ANTIOXIDANT STATUS
AB We analyzed the levels of LPO products and antioxidant defense components in women with the metabolic syndrome. Women with the metabolic syndrome had higher values of substrates with unsaturated double bonds and final TBA-reactive substances in comparison with the control group and higher levels of unsaturated double bonds, primary and end products of LPO, and retinol in comparison with the reference group (women with less than 3 signs of metabolic syndrome). No statistically significant differences between the groups were revealed while estimating the coefficient of oxidative stress; however, there was a tendency to an increase in the median value of this parameter in the group with metabolic syndrome. Thus, the results of the study indicate the activity of LPO reactions at different stages in women of reproductive age with the metabolic syndrome, which points to the necessity to evaluate and monitor the content of these metabolites in the patients of this cohort for the purpose of prevention and treatment.
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C3 Irkutsk Science Centre of the Russian Academy of Sciences; Scientific
   Centre for Family Health & Human Reproduction Problems
RP Darenskaya, MA (corresponding author), Sci Ctr Family Hlth & Human Reprod Problems, Irkutsk, Russia.
EM marina_darenskaya@inbox.ru
RI LAZAREVA, Lyudmila/K-4759-2018; Atalyan, Alina/P-4841-2015; Darenskaya,
   Marina/O-4490-2015
OI Atalyan, Alina/0000-0002-3407-9365
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   Shantir' I. I., 2019, Ekologiya Cheloveka / Human Ecology, P23, DOI 10.33396/1728-0869-2019-6-23-29
   Spahis S, 2017, ANTIOXID REDOX SIGN, V26, P445, DOI 10.1089/ars.2016.6756
   [Васюк Ю.А. Vasyuk Yu. A.], 2018, [Российский кардиологический журнал, Rossiiskii kardiologicheskii zhurnal], V23, P14, DOI 10.15829/1560-4071-2018-4-14-18
   Vona R, 2019, OXID MED CELL LONGEV, V2019, DOI 10.1155/2019/8267234
NR 15
TC 3
Z9 3
U1 0
U2 3
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0007-4888
EI 1573-8221
J9 B EXP BIOL MED+
JI Bull. Exp. Biol. Med.
PD MAR
PY 2023
VL 174
IS 5
BP 601
EP 604
DI 10.1007/s10517-023-05754-w
EA APR 2023
PG 4
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA E0EL8
UT WOS:000967784400006
PM 37040040
DA 2025-06-11
ER

PT J
AU Millar, H
AF Millar, Helen
TI Management of physical health in schizophrenia: A stepping stone to
   treatment success
SO EUROPEAN NEUROPSYCHOPHARMACOLOGY
LA English
DT Article
DE diabetes; metabolic syndrome; atypical antipsychotics
ID METABOLIC SYNDROME; CARDIOVASCULAR RISK; MORTALITY; OBESITY; CARE;
   ANTIPSYCHOTICS; INTERVENTION; ARIPIPRAZOLE; MULTICENTER; PREVALENCE
AB White patients with schizophrenia are known to have an increased risk of physical health comorbidity including coronary heart disease, diabetes, hypertension, stroke and emphysema, their physical wellbeing often goes unnoticed by health care professionals. In many cases the patient's only contact with the health service is through the mental health team. However, many psychiatrists consider their primary function to be the provision of clinical care in terms of symptom control and are reluctant to switch medication despite the presence of physical health issues. Nevertheless outcomes in schizophrenia may be improved by expanding the remit of the clinician to include assessments of both physical and mental health. Simple measurements such as waist circumference, weight, height, blood pressure and blood sampling would provide the psychiatrist with useful information that could be used to optimize treatment and improve overall quality of life for patients with schizophrenia. (c) 2008 Elsevier B.V. and ECNP. All rights reserved.
C1 Carseview Ctr, Dundee DD2 1NH, Scotland.
RP Millar, H (corresponding author), Carseview Ctr, 4 Tom McDonald Ave, Dundee DD2 1NH, Scotland.
EM h.millar@nhs.net
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NR 48
TC 29
Z9 32
U1 0
U2 11
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0924-977X
EI 1873-7862
J9 EUR NEUROPSYCHOPHARM
JI Eur. Neuropsychopharmacol.
PD MAY
PY 2008
VL 18
SU 2
BP S121
EP S128
DI 10.1016/j.euroneuro.2008.02.002
PG 8
WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA 289VA
UT WOS:000255080800005
PM 18346600
DA 2025-06-11
ER

PT J
AU Benson, C
   Kisely, S
   Korman, N
   Moss, K
AF Benson, Catherine
   Kisely, Steve
   Korman, Nicole
   Moss, Katherine
TI Compliance of metabolic monitoring at rehabilitation facilities
SO AUSTRALASIAN PSYCHIATRY
LA English
DT Article
DE metabolic syndrome; monitoring; severe mental illness; physical health;
   mental health service
ID SCHIZOPHRENIA; GUIDELINES; MANAGEMENT; PEOPLE; RISK
AB Objectives: To examine compliance with routine metabolic monitoring at four rehabilitation facilities within the Metro South Addiction and Mental Health Services in Queensland.
   Methods: A retrospective chart audit was undertaken on 63 residents of rehabilitation facilities with electronic health records from 1 October 2014 to 30 March 2015.
   Results: Evidence of any metabolic monitoring was recorded for 87% of residents. Compliance rates differed for monitoring waist circumference (97%), blood pressure (97%), high-density lipoprotein (79%), triglycerides (81%) and plasma glucose (83%). Evidence of communication with residents and primary healthcare providers were each found in 41% of the sample.
   Conclusions: In current clinical practice, metabolic monitoring is high for residents of rehabilitation facilities in Queensland with serious mental illness. However, many residents do not receive adequate communication regarding their results and, disturbingly, results are not forwarded to their primary healthcare providers. This can result in people not receiving treatment for modifiable factors of metabolic syndrome.
C1 [Benson, Catherine; Kisely, Steve; Moss, Katherine] Metro South Addict & Mental Hlth Serv, Brisbane, Qld, Australia.
   [Kisely, Steve; Moss, Katherine] Univ Queensland, Brisbane, Qld, Australia.
   [Korman, Nicole] Metro South Addict & Mental Hlth Serv, Rehabil Acad & Clin Unit, Brisbane, Qld, Australia.
C3 University of Queensland
RP Moss, K (corresponding author), Princess Alexandra Hosp, Metro South Addict & Mental Hlth Serv, 199 Ipswich Rd, Woolloongabba, Qld 4102, Australia.
EM katherine.moss@health.qld.gov.au
RI Kisely, Steve/B-4680-2012
CR Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
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NR 15
TC 4
Z9 4
U1 0
U2 1
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1039-8562
EI 1440-1665
J9 AUSTRALAS PSYCHIATRY
JI Australas. Psychiatry
PD FEB
PY 2018
VL 26
IS 1
BP 41
EP 46
DI 10.1177/1039856217737899
PG 6
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA FU4AP
UT WOS:000423795500010
PM 29087209
DA 2025-06-11
ER

PT J
AU Shivappa, N
   Hebert, JR
   Rashidkhani, B
AF Shivappa, Nitin
   Hebert, James R.
   Rashidkhani, Bahram
TI Association between Inflammatory Potential of Diet and Stress Levels in
   Adolescent Women in Iran
SO ARCHIVES OF IRANIAN MEDICINE
LA English
DT Article
DE Dietary inflammatory index; diet; Iran; inflammation; stress; adolescent
   health
ID C-REACTIVE PROTEIN; ACUTE MENTAL STRESS; COLORECTAL-CANCER;
   POSTMENOPAUSAL WOMEN; UNIVERSITY-STUDENTS; METABOLIC SYNDROME; INDEX;
   RISK; BEHAVIOR; DEPRESSION
AB Background: The relation between diet and stress has not been widely explored. In this study, we examined the association between the inflammatory potential of diet and levels of stress among adolescent girls in Iran.
   Methods: A total of 299 adolescent girls aged 15-18 years were recruited during 2014-2015. Stress was assessed using the Depression, Anxiety and Stress Scale (DASS)-21 scale. Data were analyzed as continuous DASS scores and as a dichotomous outcome with a cutoff value of 9. The dietary inflammatory index (DII) is a literature-derived population-based dietary. DII scores were index computed from dietary intake assessed using a validated food frequency questionnaire. Multivariable linear and logistic regressions were used to calculate beta estimates and odds ratios adjusting for potential confounding factors.
   Results: In total, 84 girls (28% of the entire study sample) had at least a moderate level of stress symptoms (DASS > 9). Girls with the most pro-inflammatory diet (tertile 3) had higher DASS stress scores beta = 2.75; 95% Cl = 1.05, 4.46) and were at 3.48 times (95% Cl = 1.33, 9.09) risk of having at least moderate level of stress compared to girls with the most anti-inflammatory diets (tertile 1).
   Conclusion: These data suggest that Iranian adolescent girls with a pro-inflammatory diet, as shown by higher DII scores, had higher levels of stress and greater odds of having at least a moderate level of stress symptoms.
C1 [Shivappa, Nitin; Hebert, James R.] Univ South Carolina, Canc Prevent & Control Program, Columbia, SC 29208 USA.
   [Shivappa, Nitin; Hebert, James R.] Univ South Carolina, Arnold Sch Publ Hlth, Dept Epidemiol & Biostat, Columbia, SC 29208 USA.
   [Rashidkhani, Bahram] Shahid Beheshti Univ Med Sci, WHO Collaborating Ctr, Natl Nutr & Food Technol Res Inst, Dept Community Nutr,Fac Nutr Sci & Food Technol, Tehran, Iran.
C3 University of South Carolina System; University of South Carolina
   Columbia; University of South Carolina System; University of South
   Carolina Columbia; World Health Organization; Shahid Beheshti University
   Medical Sciences
RP Rashidkhani, B (corresponding author), Shahid Beheshti Univ Med Sci, WHO Collaborating Ctr, Natl Nutr & Food Technol Res Inst, Dept Community Nutr,Fac Nutr Sci & Food Technol, Tehran, Iran.
EM rashidkhani@yahoo.com
RI Hebert, James/IUO-5628-2023; Shivappa, Nitin/X-2215-2018; rashidkhani,
   bahram/ABG-9304-2021
FU United States National Institute of Diabetes and Digestive and Kidney
   Diseases [R44DK103377]
FX Drs. Shivappa and Hebert were supported by grant number R44DK103377 from
   the United States National Institute of Diabetes and Digestive and
   Kidney Diseases.
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NR 45
TC 23
Z9 24
U1 1
U2 4
PU ACAD MEDICAL SCIENCES I R IRAN
PI TEHRAN
PA PO BOX 19395-5655, TEHRAN, 00000, IRAN
SN 1029-2977
EI 1735-3947
J9 ARCH IRAN MED
JI Arch. Iran. Med.
PD FEB
PY 2017
VL 20
IS 2
BP 108
EP 112
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA EM9FD
UT WOS:000395616000008
PM 28193086
DA 2025-06-11
ER

PT J
AU Martocchia, A
   Stefanelli, M
   Falaschi, GM
   Toussan, L
   Ferri, C
   Falaschi, P
AF Martocchia, Antonio
   Stefanelli, Manuela
   Falaschi, Giulia Maria
   Toussan, Lavinia
   Ferri, Claudio
   Falaschi, Paolo
TI Recent advances in the role of cortisol and metabolic syndrome in
   age-related degenerative diseases
SO AGING CLINICAL AND EXPERIMENTAL RESEARCH
LA English
DT Review
DE Cortisol; Metabolic syndrome; Degenerative diseases; Aging; 11
   beta-Hydroxysteroid dehydrogenase type 1
ID 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1; ADIPOSE-TISSUE;
   ALZHEIMERS-DISEASE; PROVISIONAL REPORT; SALIVARY CORTISOL;
   DIABETES-MELLITUS; ABDOMINAL OBESITY; FAT DISTRIBUTION; ALLOSTATIC LOAD;
   STRESS
AB The metabolic syndrome (MetS) presents an increasing prevalence in elderly people. A significant role in MetS is played by the stress response and cortisol. The hypothalamic-pituitary-adrenal (HPA) axis activity is increased by central (loss of hippocampal glucocorticoid receptors) and peripheral (11 beta-hydroxysteroid dehydrogenase type 1, 11 beta-HSD1, hyperactivity) mechanisms. The HPA hyperactivity has been found in chronic diseases affecting the endocrine (abdominal obesity with MetS, type 2 diabetes), cardiovascular (atherosclerosis, essential hypertension), and nervous systems (dementia, depression), in aging. A novel therapeutic approach (11 beta-HSD1 inhibition) is promising in treating the HPA axis hyperactivity in chronic diseases with MetS. A large-scale national clinical trial (AGICO, AGIng, and COrtisol study) has been proposed by our group to evaluate the role of cortisol and MetS in the main pathologies of aging (vascular and degenerative dementia, cardiovascular diseases, type 2 diabetes, abdominal obesity).
C1 [Martocchia, Antonio; Stefanelli, Manuela; Toussan, Lavinia; Falaschi, Paolo] Univ Roma La Sapienza, Geriatr Unit, Fac Med & Psychol, S Andrea Hosp, Via Grottarossa 1035, I-00199 Rome, Italy.
   [Falaschi, Giulia Maria; Ferri, Claudio] Univ Aquila, Dept Life Hlth & Environm Sci, Viale S Salvatore,Delta 6 Bldg, I-67100 Laquila, Italy.
C3 Sapienza University Rome; Azienda Ospedaliera Sant'Andrea; University of
   L'Aquila
RP Falaschi, P (corresponding author), Univ Roma La Sapienza, Geriatr Unit, Fac Med & Psychol, S Andrea Hosp, Via Grottarossa 1035, I-00199 Rome, Italy.
EM a_martocchia@virgilio.it; paolo.falaschi@uniroma1.it
RI Martocchia, Antonio/GYU-9119-2022; Ferri, Claudio/AAB-5070-2022
OI Martocchia, Antonio/0000-0002-6201-5377
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NR 64
TC 36
Z9 42
U1 2
U2 21
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1594-0667
EI 1720-8319
J9 AGING CLIN EXP RES
JI Aging Clin. Exp. Res.
PD FEB
PY 2016
VL 28
IS 1
BP 17
EP 23
DI 10.1007/s40520-015-0353-0
PG 7
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA DF3MY
UT WOS:000371249700002
PM 25813987
DA 2025-06-11
ER

PT J
AU Crombie, KM
   Adams, TG
   Dunsmoor, JE
   Greenwood, BN
   Smits, JA
   Nemeroff, CB
   Cisler, JM
AF Crombie, Kevin M.
   Adams, Tom G.
   Dunsmoor, Joseph E.
   Greenwood, Benjamin N.
   Smits, Jasper A.
   Nemeroff, Charles B.
   Cisler, Josh M.
TI Aerobic exercise in the treatment of PTSD: An examination of preclinical
   and clinical laboratory findings, potential mechanisms, clinical
   implications, and future directions
SO JOURNAL OF ANXIETY DISORDERS
LA English
DT Review
DE Fear extinction; Exposure therapy; Behavioral tagging; Pattern
   separation; Endocannabinoid system; Brain derived neurotrophic factor
ID POSTTRAUMATIC-STRESS-DISORDER; SOCIAL ANXIETY DISORDER; FEAR EXTINCTION
   MEMORY; PHYSICAL-ACTIVITY; EXPOSURE THERAPY; NEUROTROPHIC FACTOR;
   ENHANCING EXTINCTION; CONDITIONED FEAR; BRAIN; BDNF
AB Posttraumatic stress disorder (PTSD) is associated with heightened emotional responding, avoidance of trauma related stimuli, and physical health concerns (e.g., metabolic syndrome, type 2 diabetes, cardiovascular disease). Existing treatments such as exposure-based therapies (e.g., prolonged exposure) aim to reduce anxiety symptoms triggered by trauma reminders, and are hypothesized to work via mechanisms of extinction learning. However, these conventional gold standard psychotherapies do not address physical health concerns frequently presented in PTSD. In addition to widely documented physical and mental health benefits of exercise, emerging preclinical and clinical evidence supports the hypothesis that precisely timed administration of aerobic exercise can enhance the consolidation and subsequent recall of fear extinction learning. These findings suggest that aerobic exercise may be a promising adjunctive strategy for simultaneously improving physical health while enhancing the effects of exposure therapies, which is desirable given the suboptimal efficacy and remission rates. Accordingly, this review 1) encompasses an overview of preclinical and clinical exercise and fear conditioning studies which form the basis for this claim; 2) discusses several plausible mechanisms for enhanced consolidation of fear extinction memories following exercise, and 3) provides suggestions for future research that could advance the under-standing of the potential importance of incorporating exercise into the treatment of PTSD.
C1 [Crombie, Kevin M.; Dunsmoor, Joseph E.; Nemeroff, Charles B.; Cisler, Josh M.] Univ Texas Austin, Dept Psychiat & Behav Sci, 1601 Trinity St,Bldg B, Austin, TX 78712 USA.
   [Adams, Tom G.] Univ Kentucky, Dept Psychol, 105 Kastle Hill, Lexington, KY 40506 USA.
   [Adams, Tom G.] Yale Sch Med, Dept Psychiat, 300 George St, New Haven, CT 06511 USA.
   [Greenwood, Benjamin N.] Univ Colorado Denver, Dept Psychol, Campus Box 173,POB 173364, Denver, CO 80217 USA.
   [Smits, Jasper A.] Univ Texas Austin, Dept Psychol, 108 Dean Keeton St, Austin, TX 78712 USA.
   [Nemeroff, Charles B.; Cisler, Josh M.] Univ Texas Austin, Inst Early Life Advers Res, Med Sch, 1601 Trinity St,Bldg B, Austin, TX 78712 USA.
C3 University of Texas System; University of Texas Austin; University of
   Kentucky; Yale University; University of Colorado System; University of
   Colorado Denver; University of Colorado Anschutz Medical Campus;
   Children's Hospital Colorado; University of Texas System; University of
   Texas Austin; University of Texas System; University of Texas Austin
RP Crombie, KM (corresponding author), Univ Texas Austin, Dept Psychiat & Behav Sci, 1601 Trinity St,Bldg B, Austin, TX 78712 USA.
EM kevin.crombie@austin.utexas.edu
RI Cisler, Josh/L-8940-2016; Dunsmoor, Joseph/U-9183-2019; Nemeroff,
   Charles/AEU-9195-2022; Smits, Jasper/A-4350-2008
OI Nemeroff, Charles/0000-0001-7867-1160; Crombie,
   Kevin/0000-0002-3241-6815; Smits, Jasper/0000-0003-1633-9693
FU National Institute on Alcohol Abuse and Alcoholism (NIAAA/NIH)
   [T32AA007471]
FX Kevin M. Crombie is supported by a National Institute on Alcohol Abuse
   and Alcoholism (NIAAA/NIH) training grant (T32AA007471). The funding
   source had no role in the collection, analysis, and interpretation of
   data; in writing the report; or in the decision to submit the article
   for publication.
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NR 114
TC 11
Z9 11
U1 1
U2 23
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0887-6185
EI 1873-7897
J9 J ANXIETY DISORD
JI J. Anxiety Disord.
PD MAR
PY 2023
VL 94
AR 102680
DI 10.1016/j.janxdis.2023.102680
EA FEB 2023
PG 13
WC Psychology, Clinical; Psychiatry
WE Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA 9Q3RI
UT WOS:000944885100001
PM 36773486
DA 2025-06-11
ER

PT J
AU Fusar-Poli, P
   De Marco, L
   Cavallin, F
   Bertorello, A
   Nicolasi, M
   Politi, P
AF Fusar-Poli, Paolo
   De Marco, Luca
   Cavallin, Francesca
   Bertorello, Andrea
   Nicolasi, Matteo
   Politi, Pierluigi
TI Lifestyles and Cardiovascular Risk in Individuals With Functional
   Psychoses
SO PERSPECTIVES IN PSYCHIATRIC CARE
LA English
DT Article
DE Cardiovascular risk; lifestyle; prevention; psychosis; schizophrenia
ID CORONARY-HEART-DISEASE; METABOLIC SYNDROME; SCHIZOPHRENIA; PEOPLE;
   ALCOHOL; SMOKING; MORBIDITY; MORTALITY; OBESITY; HEALTH
AB This study aims to examine known determinants of cardiovascular risk in Italian patients with functional psychoses.
   A cross-sectional study design was used to examine cardiovascular risk factors and lifestyle behaviors of 123 individuals with functional psychosis and compare clinically relevant data with those of the general Italian population.
   A significant proportion of patients manifested frank hypertension (6.9%), hypercholesterolemia (20.5%), diabetes (6.5%), or a body mass index of more than 30 (20.3%). Many also smoked (63.0%) or ingested alcohol every day (26.0%), did not eat fruits or vegetables (8.0%), or did not exercise on a daily basis (34.0%).
   Patients with psychosis manifest significant rates of potentially reversible risk factors for cardiovascular diseases. Mental health nurses should advocate for and implement well-resourced counseling programs to reduce the prevalence of smoking and metabolic syndrome in mental health populations.
C1 [Fusar-Poli, Paolo; De Marco, Luca; Cavallin, Francesca; Bertorello, Andrea; Nicolasi, Matteo; Politi, Pierluigi] Univ Pavia, Dept Psychobehav Hlth Sci, I-27100 Pavia, Italy.
C3 University of Pavia
RP Fusar-Poli, P (corresponding author), Univ Pavia, Dept Psychobehav Hlth Sci, Via Palestro 3, I-27100 Pavia, Italy.
EM p.fusar@libero.it
RI Fusar-Poli, Paolo/D-8605-2011; Politi, Pierluigi/G-5070-2012
OI Fusar-Poli, Paolo/0000-0003-3582-6788; Politi,
   Pierluigi/0000-0002-4602-2032
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NR 43
TC 18
Z9 18
U1 0
U2 11
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0031-5990
EI 1744-6163
J9 PERSPECT PSYCHIATR C
JI Perspect. Psychiatr. Care
PD APR
PY 2009
VL 45
IS 2
BP 87
EP 99
DI 10.1111/j.1744-6163.2009.00202.x
PG 13
WC Nursing; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Psychiatry
GA 428ZW
UT WOS:000264891600003
PM 19366419
OA gold
DA 2025-06-11
ER

PT S
AU Kajantie, E
AF Kajantie, Eero
BE Chrousos, GP
   Tsigos, C
TI Fetal origins of stress-related adult disease
SO STRESS, OBESITY, AND METABOLIC SYNDROME
SE Annals of the New York Academy of Sciences
LA English
DT Article; Proceedings Paper
CT Bjorntorp Symposium on Stress, Obesity, and Metabolic Syndrome
CY APR 09-10, 2005
CL Athens, GREECE
SP Roche Hellas, Abbott Hellas, Pfizer Hellas, Sanofi Aventis Hellas, GlaxoSmithKline Hellas
DE programming; pregnancy; birth weight; gestational age; depression;
   metabolic syndrome; posttraumatic stress disorder; cortisol
ID LOW-BIRTH-WEIGHT; CORONARY-HEART-DISEASE; PLASMA-CORTISOL
   CONCENTRATIONS; IMPAIRED GLUCOSE-TOLERANCE; 12-YEAR-OLD CHILDREN BORN;
   PITUITARY-ADRENAL AXIS; BODY-MASS INDEX; METABOLIC SYNDROME;
   BLOOD-PRESSURE; PRENATAL STRESS
AB During the past decade, a considerable body of evidence has emerged showing that circumstances during the fetal period may have lifelong programming effects on different body functions with a considerable impact on disease susceptibility. The purpose of this article is to provide a synopsis of these findings and their role in explaining the development of stress-related adult disease. In the context of Per Bjorntorp memorial symposium, stress-related disease will be interpreted broadly, including cardiovascular disease and components of the metabolic syndrome, for which the evidence of fetal origins is most abundant. It has however become evident that early-life programming has a much broader potential effect on an individual's health. For example, perinatal variables, such as low birth weight, have been associated with increased prevalence of depressive symptoms. Mechanistic studies in animals and humans have shown that lifelong programming of the hypothalamic-pituitary-adrenal axis (HPAA) function by fetal life conditions is likely to be a key factor in mediating associations with these disorders, which frequently are characterized by HPAA overactivity. Preliminary observations suggest a similar important role for early-life programming of sympathoadrenal function. Reduced HPAA activity is characteristic of a number of stress-related disorders, including posttraumatic stress disorder; chronic pain; fatigue; and atypical, melancholic depression. It is therefore highly plausible that susceptibility to these disorders originates in a similar manner during early life, although direct evidence is to a great deal lacking. Important targets for future research include distinction between the effects of different pregnancy conditions, such as maternal malnutrition, preeclampsia, and maternal infection, which may have dissimilar late-life consequences. This will be a crucial step when the associations that are currently emerging will be translated into disease prevention.
C1 Natl Publ Hlth Inst, FIN-00300 Helsinki, Finland.
C3 Finland National Institute for Health & Welfare
RP Kajantie, E (corresponding author), Natl Publ Hlth Inst, Mannerheimintie 166, FIN-00300 Helsinki, Finland.
EM eero.kajantie@helsinki.fi
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NR 98
TC 81
Z9 96
U1 0
U2 15
PU BLACKWELL SCIENCE PUBL
PI OXFORD
PA OSNEY MEAD, OXFORD OX2 0EL, ENGLAND
SN 0077-8923
BN 978-1-57331-625-5
J9 ANN NY ACAD SCI
JI Ann.NY Acad.Sci.
PY 2006
VL 1083
BP 11
EP 27
DI 10.1196/annals.1367.026
PG 17
WC Endocrinology & Metabolism; Multidisciplinary Sciences
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Science & Technology - Other Topics
GA BFR90
UT WOS:000244102900003
PM 17148730
DA 2025-06-11
ER

PT J
AU Loukou, I
   Moustaki, M
   Douros, K
AF Loukou, Ioanna
   Moustaki, Maria
   Douros, Konstantinos
TI The Psychological Impact on Parents of Children who Receive an
   Inconclusive Diagnosis for Cystic Fibrosis following Newborn Screening:
   A Systematic Mini-Review
SO CHILDREN-BASEL
LA English
DT Review
DE anxiety; cystic fibrosis; CF related metabolic syndrome (CRMS); CF
   screen positive inconclusive diagnosis (CFSPID); newborn screening;
   perceptions; psychological impact
ID PROGRAMS
AB Newborn screening (NBS) has been available for the diagnosis of cystic fibrosis (CF) over the last decades. Through the implementation of NBS, a new designation emerged, that of CF related metabolic syndrome (CRMS) or cystic fibrosis screen positive inconclusive diagnosis (CFSPID). As there is uncertainty regarding the clinical progression of these infants to CF, some studies have investigated the psychological impact of CRMS/CFSPID on their parents. This systematic narrative review aimed to describe the findings of the relevant studies. The number of studies is limited and the study samples are relatively small. It seems that there is a negative impact of CRMS/CFSPID on parental mental health. While some studies indicated similar levels of parental anxiety among those with infants diagnosed with CF and those with CRMS/CFSPID, not all studies reached the same conclusion. Parental uncertainty represents another mental dimension of the impact associated with the designation of CRMS/CFSPID. These observations suggest that parents of infants with CRMS/CFSPID should be provided with effective communication, and it may also be beneficial to consider parental mental screening. More robust and long-term studies are required to detect differences in parental emotional status between those with infants diagnosed with CF and those with CRMS/CFSPID.
C1 [Loukou, Ioanna; Moustaki, Maria] Agia Sofia Childrens Hosp, Cyst Fibrosis Dept, Thivon 1, Athens 11527, Greece.
   [Douros, Konstantinos] Natl & Kapodistrian Univ Athens, Attikon Univ Hosp, Sch Med, Pediat Allergy & Resp Unit,Dept Pediat 3, Rimini 1, Athens 12462, Greece.
C3 The Aghia Sophia Children's Hospital; Athens Medical School; National &
   Kapodistrian University of Athens; University Hospital Attikon
RP Douros, K (corresponding author), Natl & Kapodistrian Univ Athens, Attikon Univ Hosp, Sch Med, Pediat Allergy & Resp Unit,Dept Pediat 3, Rimini 1, Athens 12462, Greece.
EM i.loukou@paidon.gr; cfcenter@paidon.gr; kdouros@med.uoa.gr
RI Cheung, Ankie Tan/GLU-2542-2022
OI Douros, Konstantinos/0000-0001-7632-1159
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   Tosco A, 2023, CHILDREN-BASEL, V10, DOI 10.3390/children10020177
NR 20
TC 3
Z9 3
U1 0
U2 3
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2227-9067
J9 CHILDREN-BASEL
JI Children-Basel
PD JAN
PY 2024
VL 11
IS 1
AR 93
DI 10.3390/children11010093
PG 9
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA FY5I7
UT WOS:001149423200001
PM 38255406
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Kerling, A
   Tegtbur, U
   Gützlaff, E
   Kück, M
   Borchert, L
   Ates, Z
   von Bohlen, A
   Frieling, H
   Hüper, K
   Hartung, D
   Schweiger, U
   Kahl, KG
AF Kerling, Arno
   Tegtbur, Uwe
   Guetzlaff, Elke
   Kueck, Momme
   Borchert, Luise
   Ates, Zeynep
   von Bohlen, Anne
   Frieling, Helge
   Hueper, Katja
   Hartung, Dagmar
   Schweiger, Ulrich
   Kahl, Kai G.
TI Effects of adjunctive exercise on physiological and psychological
   parameters in depression: A randomized pilot trial
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Depression; Metabolic syndrome; Physical exercise
ID LIFE-STYLE INTERVENTIONS; PHYSICAL-ACTIVITY; HEART-RATE; METABOLIC
   SYNDROME; METAANALYSIS; FITNESS; ADULTS; ASSOCIATION; PREVALENCE;
   THRESHOLD
AB Objective: Major depressive disorder (MDD) is associated with decreased physical activity and increased rates of the metabolic syndrome (MetS), a risk factor for the development of type 2 diabetes and cardiovascular disorders. Exercise training has been shown to improve carcliorespiratory fitness and metabolic syndrome factors. Therefore, our study aimed at examining whether patients receiving an exercise program as an adjunct to inpatient treatment will benefit in terms of physiological and psychological factors.
   Method: Fourty-two inpatients with moderate to severe depression were included. Twenty-two patients were randomized to additional 3x weekly exercise training (EXERCISE) and compared to treatment as usual (TAU). Exercise capacity was assessed as peak oxygen uptake (VO2peak), ventilatory anaerobic threshold (VAT) and workload expressed as Watts (W). Metabolic syndrome was defined according to NCEP ATPIll panel criteria.
   Results: After 6 weeks of treatment, cardiorespiratory fitness (VO2peak, VAT, Watt), waist circumference and HDL cholesterol were significantly improved in EXERCISE participants. Treatment response expressed as 50% MADRS reduction was more frequent in the EXERCISE group.
   Conclusions: Adjunctive exercise training in depressed inpatients improves physical fitness, MetS factors, and psychological outcome. Given the association of depression with cardiometablic disorders, exercise training is recommended as an adjunct to standard antidepressant treatment. (C) 2015 Elsevier B.V. All rights reserved
C1 [Kerling, Arno; Tegtbur, Uwe; Guetzlaff, Elke; Kueck, Momme] Hannover Med Sch, Inst Sports Med, D-30625 Hannover, Germany.
   [Borchert, Luise; Ates, Zeynep; von Bohlen, Anne; Frieling, Helge; Kahl, Kai G.] Hannover Med Sch, Dept Psychiat Social Psychiat & Psychotherapy, D-30625 Hannover, Germany.
   [Hueper, Katja; Hartung, Dagmar] Hannover Med Sch, Inst Radiol, D-30625 Hannover, Germany.
   [Schweiger, Ulrich] Med Univ Lubeck, Dept Psychiat & Psychotherapy, D-23538 Lubeck, Germany.
C3 Hannover Medical School; Hannover Medical School; Hannover Medical
   School; University of Lubeck
RP Kahl, KG (corresponding author), Hannover Med Sch, Dept Psychiat Social Psychiat & Psychotherapy, Carl Neuberg Str 1, D-30625 Hannover, Germany.
EM kahl.kai@mh-hannover.de
RI Frieling, Helge/C-5299-2015; Hueper, Katja/J-9566-2016
FU Servier
FX Kai G. Kahl received speaker honoraria by EliLilly, BMS, Otsuka,
   Selyier, Lundbeck and Janssen-Cilag, and received a research grant by
   Servier. Ulrich Schweiger received speaker honoraria by Astra Zeneca and
   Servier.
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NR 42
TC 72
Z9 84
U1 2
U2 68
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD MAY 15
PY 2015
VL 177
BP 1
EP 6
DI 10.1016/j.jad.2015.01.006
PG 6
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA CF0NM
UT WOS:000352240900003
PM 25743367
DA 2025-06-11
ER

PT J
AU Sobolewska-Nowak, J
   Wachowska, K
   Nowak, A
   Orzechowska, A
   Szulc, A
   Plaza, O
   Galecki, P
AF Sobolewska-Nowak, Justyna
   Wachowska, Katarzyna
   Nowak, Artur
   Orzechowska, Agata
   Szulc, Agata
   Plaza, Olga
   Galecki, Piotr
TI Exploring the Heart-Mind Connection: Unraveling the Shared Pathways
   between Depression and Cardiovascular Diseases
SO BIOMEDICINES
LA English
DT Review
DE depression; cardiovascular disease; obesity; diabetes; civilization
   diseases; mental disorders; risk factors; inflammation; interleukins;
   comorbidity
ID TYPE-2 DIABETES-MELLITUS; CORONARY-ARTERY-DISEASE; BLOOD-BRAIN-BARRIER;
   RISK-FACTOR; PHYSICAL-ACTIVITY; MYOCARDIAL-INFARCTION; SCIENTIFIC
   STATEMENT; COMORBID DEPRESSION; GENDER-DIFFERENCES; METABOLIC SYNDROME
AB Civilization diseases are defined as non-communicable diseases that affect a large part of the population. Examples of such diseases are depression and cardiovascular disease. Importantly, the World Health Organization warns against an increase in both of these. This narrative review aims to summarize the available information on measurable risk factors for CVD and depression based on the existing literature. The paper reviews the epidemiology and main risk factors for the coexistence of depression and cardiovascular disease. The authors emphasize that there is evidence of a link between depression and cardiovascular disease. Here, we highlight common risk factors for depression and cardiovascular disease, including obesity, diabetes, and physical inactivity, as well as the importance of the prevention and treatment of CVD in preventing depression and other mental disorders. Conversely, effective treatment of CVD can also help prevent depression and improve mental health outcomes. It seems advisable to introduce screening tests for depression in patients treated for cardiac reasons. Importantly, in patients treated for mood disorders, it is worth controlling CVD risk factors, for example, by checking blood pressure and pulse during routine visits. It is also worth paying attention to the mental condition of patients with CVD. This study underlines the importance of interdisciplinary co-operation.
C1 [Sobolewska-Nowak, Justyna; Wachowska, Katarzyna; Orzechowska, Agata; Galecki, Piotr] Med Univ Lodz, Dept Adult Psychiat, PL-90419 Lodz, Poland.
   [Nowak, Artur] Med Univ Lodz, Dept Immunopathol, PL-90419 Lodz, Poland.
   [Szulc, Agata; Plaza, Olga] Med Univ Warsaw, Fac Hlth Sci, Psychiat Clin, PL-02091 Warsaw, Poland.
C3 Medical University Lodz; Medical University Lodz; Medical University of
   Warsaw
RP Sobolewska-Nowak, J (corresponding author), Med Univ Lodz, Dept Adult Psychiat, PL-90419 Lodz, Poland.
EM justyna.sobolewska@stud.umed.lodz.pl; katarzyna.wachowska@umed.lodz.pl;
   artur.nowak@stud.umed.lodz.pl; agata.orzechowska@umed.lodz.pl;
   agata.szulc@wum.edu.pl; olga.w.plaza@gmail.com;
   piotr.galecki@umed.lodz.pl
RI Nowak, Artur/NHO-9068-2025; Płaza, Olga/LOR-8059-2024; Wachowska,
   Katarzyna/LBI-0230-2024; Orzechowska, Agata/S-9960-2016; Gałecki,
   Piotr/S-9594-2016
OI Galecki, Piotr/0000-0003-2447-5636; Orzechowska,
   Agata/0000-0003-2493-3959; Plaza, Olga/0000-0001-5571-2660; Wachowska,
   Katarzyna/0000-0003-2586-9864; Sobolewska-Nowak,
   Justyna/0000-0001-6545-4992; Nowak, Artur/0000-0002-4819-1278
FU Department of Psychiatry of the Medical University of Lodz
   [503/5-062-02/503-51-001-19-00]
FX The work was financed from the funds of the Department of Psychiatry of
   the Medical University of Lodz, account number
   503/5-062-02/503-51-001-19-00.
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NR 171
TC 26
Z9 27
U1 1
U2 7
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2227-9059
J9 BIOMEDICINES
JI Biomedicines
PD JUL
PY 2023
VL 11
IS 7
AR 1903
DI 10.3390/biomedicines11071903
PG 31
WC Biochemistry & Molecular Biology; Medicine, Research & Experimental;
   Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Research & Experimental Medicine;
   Pharmacology & Pharmacy
GA N6DP2
UT WOS:001037898100001
PM 37509542
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Bayerle, P
   Kerling, A
   Kück, M
   Rolff, S
   Boeck, HT
   Sundermeier, T
   Ensslen, R
   Tegtbur, U
   Lauenstein, D
   Böthig, D
   Bara, C
   Hanke, A
   Terkamp, C
   Haverich, A
   Stiesch, M
   de Zwaan, M
   Haufe, S
   Nachbar, L
AF Bayerle, Pauline
   Kerling, Arno
   Kueck, Momme
   Rolff, Simone
   Boeck, Hedwig Theda
   Sundermeier, Thorben
   Ensslen, Ralf
   Tegtbur, Uwe
   Lauenstein, Dirk
   Boethig, Dietmar
   Bara, Christoph
   Hanke, Alexander
   Terkamp, Christoph
   Haverich, Axel
   Stiesch, Meike
   de Zwaan, Martina
   Haufe, Sven
   Nachbar, Lars
TI Effectiveness of wearable devices as a support strategy for maintaining
   physical activity after a structured exercise intervention for employees
   with metabolic syndrome: a randomized controlled trial
SO BMC SPORTS SCIENCE MEDICINE AND REHABILITATION
LA English
DT Article
DE Physical activity; Telemonitoring; Wearable device; Metabolic syndrome;
   Sustainability; Maintenance; Company employees; Work ability
ID LIFE-STYLE INTERVENTION; HEALTH-BENEFITS; OLDER-ADULTS; ASSOCIATION;
   DEPRESSION; ANXIETY; METAANALYSIS; POPULATION; DISEASE; RISK
AB Background Metabolic syndrome (MetS) is associated with an increased risk for cardiovascular events and high socioeconomic costs. Despite lifestyle interventions focusing on exercise are effective strategies to improve parameters of the above aspects, many programs fail to show sustained effects in the long-term. Methods At visit 2 (V2) 129 company employees with diagnosed MetS, who previously participated in a 6-month telemonitoring-supported exercise intervention, were randomized into three subgroups for a 6-month maintenance treatment phase. A wearable activity device was provided to subgroup A and B to assess and to track physical activity. Further subgroup A attended personal consultations with individual instructions for exercise activities. Subgroup C received neither technical nor personal support. 6 months later at visit (V3), changes in exercise capacity, MetS severity, work ability, health-related quality of life and anxiety and depression were compared between the subgroups with an analysis of variance with repeated measurements. Results The total physical activity (in MET*h/week) declined between visit 2 and visit 3 (subgroup A: V2: 48.0 +/- 33.6, V3: 37.1 +/- 23.0; subgroup B: V2: 52.6 +/- 35.7, V3: 43.8 +/- 40.7, subgroup C: V2: 51.5 +/- 29.7, V3: 36.9 +/- 22.8, for all p = 0.00) with no between-subgroup differences over time (p = 0.68). In all three subgroups the initial improvements in relative exercise capacity and MetS severity were maintained. Work ability declined significantly in subgroup C (V2: 40.3 +/- 5.0, V3: 39.1 +/- 5.7; p < 0.05), but remained stable in the other subgroups with no between-subgroup differences over time (p = 0.38). Health-related quality of life and anxiety and depression severity also showed no significant differences over time. Conclusions Despite the maintenance of physical activity could not be achieved, most of the health related outcomes remained stable and above baseline value, with no difference regarding the support strategy during the maintenance treatment phase. Trial registration The study was completed as a cooperation project between the Volkswagen AG and the Hannover Medical School (ClinicalTrials.gov Identifier: NCT02029131).
C1 [Bayerle, Pauline; Kerling, Arno; Kueck, Momme; Rolff, Simone; Boeck, Hedwig Theda; Sundermeier, Thorben; Tegtbur, Uwe; Hanke, Alexander; Haufe, Sven] Hannover Med Sch, Inst Sports Med, Carl Neuberg Str 1, D-30625 Hannover, Germany.
   [de Zwaan, Martina] Hannover Med Sch, Dept Psychosomat Med & Psychotherapy, Hannover, Germany.
   [Ensslen, Ralf; Nachbar, Lars] Volkswagen AG, Wolfsburg, Germany.
   [Lauenstein, Dirk] Audi BKK Hlth Insurance, Ingolstadt, Germany.
   [Boethig, Dietmar; Bara, Christoph; Haverich, Axel] Hannover Med Sch, Dept Cardiac Thorac Transplantat & Vasc Surg, Hannover, Germany.
   [Terkamp, Christoph] Hannover Med Sch, Dept Gastroenterol Hepatol & Endocrinol, Hannover, Germany.
   [Stiesch, Meike] Hannover Med Sch, Dept Prosthet Dent & Biomed Mat Sci, Hannover, Germany.
C3 Hannover Medical School; Hannover Medical School; Volkswagen; Volkswagen
   Germany; Hannover Medical School; Hannover Medical School; Hannover
   Medical School
RP Bayerle, P (corresponding author), Hannover Med Sch, Inst Sports Med, Carl Neuberg Str 1, D-30625 Hannover, Germany.
EM bayerle.pauline@mh-hannover.de
RI Haverich, Axel/AAC-7552-2022; Haufe, Sven/G-1944-2011; Stiesch,
   Meike/GRX-4992-2022
OI Boeck, Hedwig Theda/0000-0001-9588-4336
FU Audi BKK health insurance; German Research Foundation through the
   Cluster of Excellence "REBIRTH"
FX This study was supported and funded by grants from Audi BKK health
   insurance and the German Research Foundation through the Cluster of
   Excellence "REBIRTH". We acknowledge the support of the volunteers. We
   thank the nurses and technicians at Volkswagen occupational healthcare
   centers for collecting the anthropometric, body composition, and
   metabolic data, and collecting and analyzing blood samples.
CR [Anonymous], 2021, WHO GUID PHYS SED BE
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NR 30
TC 3
Z9 3
U1 1
U2 13
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 2052-1847
J9 BMC SPORTS SCI MED R
JI BMC Sports Sci. Med. Rehabil.
PD FEB 10
PY 2022
VL 14
IS 1
AR 24
DI 10.1186/s13102-022-00409-1
PG 10
WC Rehabilitation; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Rehabilitation; Sport Sciences
GA YX2FW
UT WOS:000753924700001
PM 35144658
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Eftekhari, S
   Alipour, F
   Aminian, O
   Saraei, M
AF Eftekhari, Sahar
   Alipour, Faezeh
   Aminian, Omid
   Saraei, Maryam
TI The association between job stress and metabolic syndrome among medical
   university staff
SO JOURNAL OF DIABETES AND METABOLIC DISORDERS
LA English
DT Article
DE Metabolic syndrome; Psychosocial factors; Copenhagen Psychosocial
   Questionnaire; Job stress
AB Background The relationship between job stress and each component of metabolic syndrome has been previously suggested; however, this association is not consistent. The present study was conducted to assess the association between job stress and metabolic syndrome and its components in a group of Iranian workers affiliated with Tehran University of Medical Sciences. Methodology This cross-sectional study was performed on 3,537 randomly selected staff in Tehran University of Medical Sciences including the staff of clinical, administrative, and service departments with at least one year of working experience. The overall frequency of metabolic syndrome was assessed based on the international diabetes federation (IDF) criteria. The Persian version of the Copenhagen Psychosocial Questionnaire (COPSOQ) was used to measure major domains of psychosocial factors in the workplace. Results The overall frequency of metabolic syndrome in the assessed personnel was estimated to be 22.1 % and there was a significantly higher rate of metabolic syndrome in office workers and service personnel compared to clinical staff (OR: 1.51, CI 95 %: 1.25-1.82 and OR: 1.74, CI 95 %: 1.41-2.14, respectively). Health and well-being as a major domain of COPSOQ was found to be significantly impaired by the presence of metabolic syndrome. According to the results of multiple logistic regression modeling, the relationship between metabolic syndrome and impaired health and well-being domain remained significant after adjusting for age, gender, marital status, educational level, and employment category. Conclusions Our findings revealed a close association between job-related stress and the impaired well-being in the presence of metabolic syndrome among the medical university staff.
C1 [Eftekhari, Sahar; Alipour, Faezeh; Aminian, Omid; Saraei, Maryam] Univ Tehran Med Sci, Ctr Res Occupat Dis, Tehran, Iran.
C3 Tehran University of Medical Sciences
RP Saraei, M (corresponding author), Univ Tehran Med Sci, Ctr Res Occupat Dis, Tehran, Iran.
EM m-saraei@tums.ac.ir
OI saraei, maryam/0000-0001-9395-5735
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NR 30
TC 10
Z9 10
U1 0
U2 12
PU SPRINGER INTERNATIONAL PUBLISHING AG
PI CHAM
PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND
EI 2251-6581
J9 J DIABETES METAB DIS
JI J. Diabetes Metab. Disord.
PD JUN
PY 2021
VL 20
IS 1
BP 321
EP 327
DI 10.1007/s40200-021-00748-9
EA FEB 2021
PG 7
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA SW4XZ
UT WOS:000614910900005
PM 34178840
OA Green Published
DA 2025-06-11
ER

PT J
AU Dutta, A
   Aruchunan, M
   Mukherjee, A
   Metri, KG
   Ghosh, K
   Basu-Ray, I
AF Dutta, Abhijit
   Aruchunan, Mooventhan
   Mukherjee, Anindya
   Metri, Kashinath G.
   Ghosh, Kuntal
   Basu-Ray, Indranill
TI A Comprehensive Review of Yoga Research in 2020
SO JOURNAL OF INTEGRATIVE AND COMPLEMENTARY MEDICINE
LA English
DT Review
DE yoga; meditation; clinical research; trials
ID BIBLIOMETRIC ANALYSIS; INTERVENTION; THERAPY; STRESS; HEALTH; WOMEN;
   MEDITATION; EXERCISE; PEOPLE
AB Objectives: Accumulated evidence garnered in the last few decades has highlighted the role of yoga in health and disease. The overwhelming mortality and morbidity mediated by noncommunicable epidemics such as heart disease and cancer have fostered a search for mechanisms to attenuate them. Despite overwhelming success in acute care, the efficacy of modern medicines has been limited on this front. Yoga is one of the integrative therapies that has come to light as having a substantial role in preventing and mitigating such disorders. It thus seems trite to analyze and discuss the research advancements in yoga for 2020. The present review attempts to distill recent research highlights from voluminous literature generated in 2020.
   Methods: This review was conducted on the articles published or assigned to an issue in 2020. The authors searched the PubMed database for clinical studies published in the English language, using yoga (including meditation) as the intervention, and having an adequate description of the intervention. Then, they extracted data from each study into a standardized Google sheet.
   Results: A total of 1149 citations were retrieved in the initial search. Of these, 46 studies met eligibility criteria and were finally included. The studies were predominantly on mental health and neuropsychology, addressing various issues such as anxiety, postural balance, migraine, academic performance, and childhood neglect. Anxiety, stress, and depression were other common denominators. Eight studies were on cardiorespiratory systems, including exercise capacity, cardiac rehabilitation, myocardial infarction, and hypertension. Three studies were on diabetes, evaluating the effect of yoga. Five studies focused on cognition, health status, and autonomic regulation and few others included cancers, infertility, ulcerative colitis, urinary incontinence, restless leg syndrome, rheumatoid arthritis, chronic pain, and metabolic syndrome. Finally, most studies were on noncommunicable diseases with one exception, human immunodeficiency virus; two randomized controlled trials were dedicated to it.
   Conclusions: Yoga has been studied under a wide variety of clinicopathological conditions in the year 2020. This landscape review intends to provide an idea of the role of yoga in various clinical conditions and its future therapeutic implications.
C1 [Dutta, Abhijit] Adv Yoga Res Council, AAYM, Germantown, TN USA.
   [Aruchunan, Mooventhan] Govt Yoga & Naturopathy Med Coll, Dept Res, Chennai, Tamil Nadu, India.
   [Mukherjee, Anindya] NRS Med Coll, Dept Cardiol, Kolkata, India.
   [Metri, Kashinath G.] Cent Univ Rajasthan, Dept Yoga, Ajmer, India.
   [Ghosh, Kuntal] Manipur Univ, Dept Yoga, Imphal, Manipur, India.
   [Basu-Ray, Indranill] Memphis VA Med Ctr, Dept Cardiol, 1030 Jefferson Ave, Memphis, TN 38104 USA.
   [Basu-Ray, Indranill] Univ Memphis, Sch Publ Hlth, Memphis, TN USA.
   [Basu-Ray, Indranill] All India Inst Med Sci, Integrat Cardiol, Rishikesh, India.
C3 Central University of Rajasthan (CURAJ); Manipur University; US
   Department of Veterans Affairs; Veterans Health Administration (VHA);
   Memphis VA Medical Center; University of Memphis; All India Institute of
   Medical Sciences (AIIMS) Rishikesh
RP Basu-Ray, I (corresponding author), Memphis VA Med Ctr, Dept Cardiol, 1030 Jefferson Ave, Memphis, TN 38104 USA.
EM indranill.basu-ray@va.gov
RI A., Mooventhan/AAG-3776-2020; Ray, Indranill/D-3794-2011; Dutta,
   Abhijit/AAA-1069-2021
OI Dutta, Abhijit/0000-0002-1864-0685; Basu Ray,
   Indranill/0000-0003-0961-0588; Metri, Dr Kashinath/0000-0001-7928-4840
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NR 62
TC 12
Z9 12
U1 3
U2 35
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 2768-3605
EI 2768-3613
J9 J INTEGR COMPLEMENT
JI J. Integr. Complement. Med.
PD FEB 1
PY 2022
VL 28
IS 2
BP 114
EP 123
DI 10.1089/jicm.2021.0420
PG 10
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA 7A6ME
UT WOS:000898566900004
PM 35099279
DA 2025-06-11
ER

PT J
AU Jakovljevic, M
   Reiner, Z
   Milicic, D
AF Jakovljevic, Miro
   Reiner, Zeljko
   Milicic, Davor
TI Mental disorders, treatment response, mortality and serum cholesterol: A
   new holistic look at old data
SO PSYCHIATRIA DANUBINA
LA English
DT Review
DE cholesterol; HDL; LDL; mortality; mental disorders; treatment response;
   coronary heart disease
ID GENERALIZED ANXIETY DISORDER; PLASMA-LIPID LEVELS;
   CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; PLATELET SEROTONIN;
   ALZHEIMERS-DISEASE; MAJOR DEPRESSION; PANIC DISORDER; SUICIDE; MOOD
AB Background: The importance of cholesterol for physical and psychological well-being has been recognized for several decades. Changes in serum cholesterol levels may have a direct impact on mental performance, behavior, treatment response, survival and expected lifetime duration.
   Objectives: To examine the association between various mental disorders (schizophrenia, bipolar disorder, depression, generalized anxiety disorder, panic disorders, post-traumatic stress disorder and other mental disorders) and cholesterol levels, and to discuss the possible treatment implications.
   Method: A MEDLINE search, citing articles from 1966 onward, supplemented by a review of bibliographies, was conducted to identify relevant studies. Criteria used to identify studies included (1) English language, (2) published studies with original data in peer-reviewed journals.
   Results: Clinical investigations of cholesterolemia in patients with major mental disorders have produced very conflicting results. Hypercholesterolemia has been reported in patients with schizophrenia, obsessive-compulsive disorders, panic disorder, generalized anxiety disorder, PTSD. Low cholesterol level has been reported in patients with major depression, dissociative disorder, antisocial personality disorder, borderline personality disorder. It seems that both high and low serum total cholesterol may be associated with a higher risk of the premature death.
   Conclusion: Our current knowledge on the relation between cholesterolemia and mental disorders is poor and controversial. No definite or reliable insight into a pathophysiological link between cholesterol levels and mental disorders, treatment response and mortality rate is available. The lipoprotein profile, rather than total cholesterol levels, seems to be important.
C1 Univ Zagreb, Clin Hosp Ctr, Univ Psychiat Clin Rebro, Zagreb 10000, Croatia.
   [Reiner, Zeljko] Univ Zagreb, Univ Hosp Ctr, Dept Internal Med, Zagreb, Croatia.
   [Milicic, Davor] Univ Zagreb, Univ Hosp Ctr, Dept Cardiovasc Dis, Zagreb, Croatia.
   [Jakovljevic, Miro] Univ Zagreb, Univ Hosp Ctr, Dept Psychiat, Zagreb, Croatia.
C3 University of Zagreb; University of Zagreb; University of Zagreb;
   University of Zagreb
RP Jakovljevic, M (corresponding author), Univ Zagreb, Clin Hosp Ctr, Univ Psychiat Clin Rebro, Kispaticeva 12, Zagreb 10000, Croatia.
EM miro.jakovljevic@mef.hr
RI Milicic, Davor/U-4225-2019
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NR 97
TC 30
Z9 30
U1 0
U2 15
PU MEDICINSKA NAKLADA
PI ZAGREB
PA VLASKA 69, HR-10000 ZAGREB, CROATIA
SN 0353-5053
J9 PSYCHIAT DANUB
JI Psychiatr. Danub.
PD DEC
PY 2007
VL 19
IS 4
BP 270
EP 281
PG 12
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 272HA
UT WOS:000253849300002
PM 18000478
DA 2025-06-11
ER

PT J
AU Pannier, B
   Thomas, F
   Eschwège, E
   Bean, K
   Benetos, A
   Leocmach, Y
   Danchin, N
   Guize, L
AF Pannier, B.
   Thomas, F.
   Eschwege, E.
   Bean, K.
   Benetos, A.
   Leocmach, Y.
   Danchin, N.
   Guize, L.
TI Cardiovascular risk markers associated with the metabolic syndrome in a
   large French population:: the SYMFONIE study
SO DIABETES & METABOLISM
LA English
DT Article
DE epidemiology; metabolic syndrome; inflammation; pulse pressure; heart
   rate; psychosocial factors; hepatic abnormalities
ID MYOCARDIAL-INFARCTION; PERIODONTAL-DISEASE; INSULIN-RESISTANCE;
   HEART-RATE; ALL-CAUSE; MORTALITY; PREVALENCE; EPIDEMIOLOGY
AB Objective: The SYMFONIE study was designed to analyze the clinical and biological characteristics, and the cardiovascular risk markers, in men and women with the metabolic syndrome compared to control subjects.
   Research Design and Methods: The study population included 101,697 men and women, 18 to 80 years of age, who had a health checkup at the Centre d'Investigations Preventives et Cliniques (Paris, France) between 1997 to 2002. The metabolic syndrome was defined according to the ATPIII-NCEP 2001 criteria.
   Results: Out of the 66,202 men (47.4 +/- 11.8 years) and 35,495 women (48.5 +/- 13.6 years) included in this population, 6761 men (10.2%) and 2155 women (6.1%) presented the metabolic syndrome. Among subjects >= 40 years of age, the prevalence of the metabolic syndrome was 5.0% in men and 2.2% in women, and rose to 14.1% and 12.0%, respectively, among men and women > 70 years of age. After adjustment for age, patients with the metabolic syndrome presented higher pulse pressure (systolic minus diastolic blood pressure), higher heart rate, lower vital respiratory capacity, lower physical activity, an increase in inflammatory status assessed through leukocyte count and dental inflammation, hepatic abnormalities, and increased levels of stress and depression.
   Conclusion: In this large French population, the prevalence of the metabolic syndrome is lower than in North American and northern European populations. Patients with the metabolic syndrome present several additional hemodynamic, inflammatory and psychological risk markers which could contribute to the poor cardiovascular prognosis of these subjects.
C1 Ctr Invest Prevent & Clin, IPC, F-75116 Paris, France.
   Univ Paris 05, Paris, France.
   INSERM, U780, IFR69, Villejuif, France.
   FOURNIER Pharma, Suresnes, France.
   Med Sch Nancy, Dept Geriatr, Nancy, France.
C3 Universite Paris Cite; Institut National de la Sante et de la Recherche
   Medicale (Inserm); Universite de Lorraine
RP Thomas, F (corresponding author), Ctr Invest Prevent & Clin, IPC, 6-14,Rue Perouse, F-75116 Paris, France.
EM thomas@ipc.asso.fr
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NR 27
TC 48
Z9 51
U1 0
U2 6
PU MASSON EDITEUR
PI MOULINEAUX CEDEX 9
PA 21 STREET CAMILLE DESMOULINS, ISSY, 92789 MOULINEAUX CEDEX 9, FRANCE
SN 1262-3636
EI 1878-1780
J9 DIABETES METAB
JI Diabetes Metab.
PD NOV
PY 2006
VL 32
IS 5
BP 467
EP 474
DI 10.1016/S1262-3636(07)70305-1
PN 1
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 106FY
UT WOS:000242087600009
PM 17110902
DA 2025-06-11
ER

PT J
AU Smith, C
   Viljoen, JT
   McGeachie, L
AF Smith, Carine
   Viljoen, Jeandre T.
   McGeachie, Lauren
TI African drumming: a holistic approach to reducing stress and improving
   health?
SO JOURNAL OF CARDIOVASCULAR MEDICINE
LA English
DT Article
DE anxiety; blood pressure; djembe; heart rate
ID BLOOD-PRESSURE; METABOLIC SYNDROME; ENDURANCE EXERCISE; DYNAMIC
   EXERCISE; MUSIC-THERAPY; RESISTANCE; ANXIETY
AB AimsVery little data are available on the physical requirements for drumming and the potential health benefits of particularly djembe drumming. We hypothesized that djembe drumming constitutes low-to-moderate intensity exercise, and that drumming would simultaneously reduce stress and anxiety levels and benefit cardiovascular health.MethodsTwo study populations, middle-aged experienced drummers and a younger novice group participated in 40-min djembe drumming sessions. Measurements of blood pressure, blood lactate and stress and anxiety levels were taken before and after sessions. Also, heart rate was monitored at 5-s intervals throughout each session.ResultsParticipation in drumming significantly decreased the Stress Anxiety Index scores acutely, both in a middle-aged (P<0.01) and younger population (P<0.001). SBP was significantly decreased in the older population postdrumming (14124 vs. 153 +/- 26mmHg; P<0.01). Blood lactate levels remained below 4mmol/l in all individuals and together with heart rate suggest that drumming may be categorized as low-to-moderate intensity exercise.ConclusionDjembe drumming may improve cardiovascular health, without the cardiovascular risks to unhealthy or older populations that are associated with higher intensity exercise, and at the same time may decrease stress and anxiety levels. Furthermore, participation in drumming did not result in acute hypotension in normotensive individuals.
C1 [Smith, Carine; Viljoen, Jeandre T.; McGeachie, Lauren] Univ Stellenbosch, Dept Physiol Sci, ZA-7600 Stellenbosch, South Africa.
C3 Stellenbosch University
RP Smith, C (corresponding author), Univ Stellenbosch, Dept Physiol Sci, Private Bag X1, ZA-4388 Matieland, South Africa.
EM csmith@sun.ac.za
RI Smith, Carine/D-7159-2012
OI Smith, Carine/0000-0001-5924-9204
FU Stellenbosch University Subcommittee B
FX Stellenbosch University Subcommittee B provided financial support.
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NR 34
TC 17
Z9 21
U1 0
U2 23
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1558-2027
EI 1558-2035
J9 J CARDIOVASC MED
JI J. Cardiovasc. Med.
PD JUN
PY 2014
VL 15
IS 6
BP 441
EP 446
DI 10.2459/JCM.0000000000000046
PG 6
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA AH6RW
UT WOS:000336259400002
PM 24983262
DA 2025-06-11
ER

PT J
AU Cadenhead, KS
   Minichino, A
   Kelsven, S
   Addington, J
   Bearden, C
   Cannon, TD
   Cornblatt, BA
   Mathalon, D
   McGlashan, TH
   Perkins, DO
   Seidman, LJ
   Tsuang, M
   Walker, EF
   Woods, SW
   Yao, J
AF Cadenhead, Kristin S.
   Minichino, Amedeo
   Kelsven, Skylar
   Addington, Jean
   Bearden, Carrie
   Cannon, Tyrone D.
   Cornblatt, Barbara A.
   Mathalon, Dan
   McGlashan, Thomas H.
   Perkins, Diana O.
   Seidman, Larry J.
   Tsuang, Ming
   Walker, Elaine F.
   Woods, Scott W.
   Yao, Jeff
CA North Amer Prodromal Longitudinal
TI Metabolic abnormalities and low dietary Omega 3 are associated with
   symptom severity and worse functioning prior to the onset of psychosis:
   Findings from the North American Prodrome Longitudinal Studies
   Consortium
SO SCHIZOPHRENIA RESEARCH
LA English
DT Article
DE Metabolic; Omega 3; Oxidative stress; Clinical high risk; Fatty acid
ID OXIDATIVE STRESS; FATTY-ACID; 1ST-EPISODE SCHIZOPHRENIA;
   CARDIOVASCULAR-DISEASE; CARDIOMETABOLIC RISK; FISH CONSUMPTION; 1ST
   EPISODE; GLUCOSE; OBESITY; BRAIN
AB Objective: Patients with schizophrenia have a high prevalence of metabolic disorders and cardiovascular mortality. It is possible that a vulnerability to metabolic abnormalities is associated with risk for psychosis, symptoms and functionality. In this study, we evaluate demographic information, cardiometabolic indices, symptoms and functioning in an antipsychotic free cohort at Clinical High Risk (CHR) for psychosis from the NAPLS Omega 3 fatty acid clinical trial.
   Method: Subjects received physical exams and metabolic monitoring prior to randomization into the Omega 3 versus Placebo trial. Anthropometrical measures, vital signs, glucose, and lipids were assessed along with symptoms, functioning, dietary Omega 3 fatty adds, erythrocyte polyunsaturated fatty add content and a measure of lipid peroxidation (TBARS, Thiobarbituric add-reactive substances).
   Results: The sample included 113 CHR subjects (42.1% female; 17.5% Latino) ages 12-29. The mean BMI was 24.3 with a trend toward higher BMI and a higher incidence of metabolic syndrome in Latino subjects; 36% of the sample was obese/overweight; 37.6% met criteria for prehypertension/hypenension; 4.2% met criteria for prediabetesAliabetes; 9.6% showed evidence of insulin resistance and 44.7% had dyslipidemia. The TBARS was elevated at 9.8 mu M +/- 6.1 (normal 1.86-3.94 mu M). Metabolic parameters and a diet low in Omega 3 rich foods were significantly associated with prodromal symptoms and poor functioning.
   Conclusions: CHR subjects show a high percentage of metabolic abnormalities prior to exposure to antipsychotic medication. These findings reinforce that early detection of metabolic disturbances and food insecurity is crucial since these factors are modifiable with the potential for significant gains in terms of quality of life, physical and mental health. (C) 2018 Elsevier B.V. All rights reserved.
C1 [Cadenhead, Kristin S.; Kelsven, Skylar; Tsuang, Ming] Univ Calif San Diego, La Jolla, CA 92093 USA.
   [Minichino, Amedeo] Univ Oxford, Dept Psychiat, Oxford, England.
   [Addington, Jean] Univ Calgary, Hotchkiss Brain Inst, Calgary, AB, Canada.
   [Bearden, Carrie] Univ Calif Los Angeles, Los Angeles, CA USA.
   [Cannon, Tyrone D.; McGlashan, Thomas H.; Woods, Scott W.] Yale Univ, New Haven, CT USA.
   [Cornblatt, Barbara A.] Zucker Hillside Hosp, New York, NY USA.
   [Cornblatt, Barbara A.] Hofstra North Shore LIJ Sch Med, Hempstead, NY USA.
   [Cornblatt, Barbara A.] Feinstein Inst Med Res, Manhasset, NY USA.
   [Mathalon, Dan] Univ Calif San Francisco, San Francisco, CA 94143 USA.
   [Perkins, Diana O.] Univ N Carolina, Chapel Hill, NC 27515 USA.
   [Seidman, Larry J.] Harvard, Boston, MA USA.
   [Walker, Elaine F.] Emory Univ, Atlanta, GA 30322 USA.
   [Yao, Jeff] VA Pittsburgh Healthcare Syst, Pittsburgh, PA USA.
   [Yao, Jeff] Univ Pittsburg, Sch Med, Pittsburgh, PA USA.
   [Kelsven, Skylar] San Diego State Univ Univ Calif San Diego Joint D, San Diego, CA USA.
C3 University of California System; University of California San Diego;
   University of Oxford; University of Calgary; University of California
   System; University of California Los Angeles; Yale University; Northwell
   Health; Northwell Health; Hofstra University; Northwell Health;
   University of California System; University of California San Francisco;
   University of North Carolina; University of North Carolina Chapel Hill;
   Emory University; US Department of Veterans Affairs; Veterans Health
   Administration (VHA); VA Pittsburgh Healthcare System; Pennsylvania
   Commonwealth System of Higher Education (PCSHE); University of
   Pittsburgh; California State University System; San Diego State
   University
RP Cadenhead, KS (corresponding author), Univ Calif San Diego, Dept Psychiat, 0810,9500 Gilman Dr, La Jolla, CA 92093 USA.
EM kcadenhead@ucsd.edu
RI Mathalon, Daniel/AEE-5878-2022; Addington, Jean/ACR-3912-2022; Walker,
   Elaine/GXN-2537-2022; Cadehead, Kristin/JCN-4886-2023; Woods,
   Scott/AAF-4811-2020; Minichino, Amedeo/Q-1809-2015; Perkins,
   Diana/F-5213-2013
OI Tsuang, Ming/0000-0002-0076-5340; Cadenhead,
   Kristin/0000-0002-5952-4605; Bearden, Carrie/0000-0002-8516-923X;
   Minichino, Amedeo/0000-0002-6309-6324; Perkins,
   Diana/0000-0001-9396-2206
FU National Institute of Mental Health [R01 U01 MH082022, U01MH081984, U01
   MH081928, P50 MH080272]; Commonwealth of Massachusetts
   [SCDMH82101008006, U01MH081902, P50 MH066286, U01MH082004, U01MH081988,
   U01MH082022, UO1 MH081857-05]
FX This study was supported by the National Institute of Mental Health (R01
   U01 MH082022 to Dr. Cadenhead, grant U01MH081984 to Dr. Addington;
   grants U01 MH081928; P50 MH080272); Commonwealth of Massachusetts
   SCDMH82101008006 to Dr. Seidman; grant U01MH081902 to Dr. Cannon; P50
   MH066286 (Prodromal Core) to Dr. Bearden; grant U01MH082004 to Dr.
   Perkins; grant U01MH081988 to Dr. Walker; grant U01MH082022 to Dr.
   Woods; and UO1 MH081857-05 grant to Dr. Cornblatt.
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NR 52
TC 37
Z9 37
U1 3
U2 14
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0920-9964
EI 1573-2509
J9 SCHIZOPHR RES
JI Schizophr. Res.
PD FEB
PY 2019
VL 204
BP 96
EP 103
DI 10.1016/j.schres.2018.09.022
PG 8
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA HN3VX
UT WOS:000460113900016
PM 30249470
OA Green Accepted, Green Submitted
DA 2025-06-11
ER

PT J
AU Gerber, M
   Isoard-Gautheur, S
   Schilling, R
   Ludyga, S
   Brand, S
   Colledge, F
AF Gerber, Markus
   Isoard-Gautheur, Sandrine
   Schilling, Rene
   Ludyga, Sebastian
   Brand, Serge
   Colledge, Flora
TI When Low Leisure-Time Physical Activity Meets Unsatisfied Psychological
   Needs: Insights From a Stress-Buffer Perspective
SO FRONTIERS IN PSYCHOLOGY
LA English
DT Article
DE autonomy; burnout; competence; relatedness; self-determination theory;
   stress
ID SELF-DETERMINATION THEORY; PSYCHOSOCIAL STRESS; MENTAL-HEALTH; ACTIVITY
   QUESTIONNAIRE; METABOLIC SYNDROME; SOCIAL SUPPORT; JOB RESOURCES;
   BURNOUT; SATISFACTION; DEPRESSION
AB Background: Few studies have tested whether the stress-buffering effects of leisure-time physical activity (LTPA) depend on other resources, such as the satisfaction of basic psychological needs. Therefore, the present study examines the interaction between perceived stress, LTPA and psychological need satisfaction (PNS) on occupational burnout symptoms in a sample of Swiss workers.
   Methods: The sample consisted of 306 employees (48% women; M-age = 42.9 years, SD = 14.1). Perceived stress was assessed with the Perceived Stress Scale, LTPA with the International Physical Activity Questionnaire, PNS (autonomy, relatedness, and competence) with the Need Satisfaction Scale, and occupational burnout symptoms with the Shirom-Melamed Burnout Measure. A hierarchical regression analysis and single slopes tests were performed to examine two-and three-way interactions.
   Results: Stress was positively correlated with burnout, and negatively correlated with LTPA and PNS levels. LTPA was positively associated with PNS, and negatively correlated with burnout. A negative association existed between PNS and burnout. In the hierarchical regression analysis, all main effects, two-and three-way interactions were significant. People who engaged in more LTPA reported fewer burnout symptoms, if they reported high stress. However, the potential of LTPA to buffer stress was particularly evident in participants who reported low PNS.
   Conclusion: If adult workers are exposed to elevated stress, they are particularly likely to show increased burnout levels if they report low LTPA in combination with low PNS, specifically a lack of autonomy, competence and relatedness.
C1 [Gerber, Markus; Schilling, Rene; Ludyga, Sebastian; Brand, Serge; Colledge, Flora] Univ Basel, Sport Sci Sect, Dept Sport Exercise & Hlth, Basel, Switzerland.
   [Isoard-Gautheur, Sandrine] Univ Grenoble Alpes, Lab Sport & Environm Social, Grenoble, France.
   [Brand, Serge] Univ Basel, Ctr Affect Stress & Sleep Disorders, Basel, Switzerland.
   [Brand, Serge] Kermanshah Univ Med Sci, Subst Abuse Prevent & Sleep Disorders Res Ctr, Kermanshah, Iran.
C3 University of Basel; Swiss School of Public Health (SSPH+); Communaute
   Universite Grenoble Alpes; Universite Grenoble Alpes (UGA); University
   of Basel; Kermanshah University of Medical Sciences
RP Gerber, M (corresponding author), Univ Basel, Sport Sci Sect, Dept Sport Exercise & Hlth, Basel, Switzerland.
EM markus.gerber@unibas.ch
RI Gerber, Markus/H-8654-2014; Brand, Serge/H-7159-2019; Ludyga,
   Sebastian/H-9316-2019; Isoard-Gautheur, Sandrine/AAE-7668-2020
OI Ludyga, Sebastian/0000-0002-3905-7894; Brand, Serge/0000-0003-2175-2765;
   Gerber, Markus/0000-0001-6140-8948; Isoard-Gautheur,
   Sandrine/0000-0003-1019-3371
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NR 88
TC 19
Z9 21
U1 1
U2 19
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-1078
J9 FRONT PSYCHOL
JI Front. Psychol.
PD NOV 2
PY 2018
VL 9
AR 2097
DI 10.3389/fpsyg.2018.02097
PG 13
WC Psychology, Multidisciplinary
WE Social Science Citation Index (SSCI)
SC Psychology
GA GZ0XY
UT WOS:000449090100001
PM 30450065
OA gold, Green Published, Green Accepted
DA 2025-06-11
ER

PT J
AU Singh, NK
   Karki, L
AF Singh, Niraj Kumar
   Karki, Lochan
TI Metabolic Syndrome in Patients with Chronic Obstructive Pulmonary
   Disease in Medicine Department of a Tertiary Care Hospital: A
   Descriptive Cross-sectional Study
SO JOURNAL OF NEPAL MEDICAL ASSOCIATION
LA English
DT Article
DE cachexia; co-morbidities; COPD; metabolic syndrome; systemic
   inflammation
AB Introduction: The best recognized systemic manifestations of chronic obstructive pulmonary disease include, cardiovascular co-morbidities, cachexia and muscle dysfunction, osteoporosis, anemia, and clinical depression and anxiety. This study was undertaken to find the prevalence of the metabolic syndrome in chronic obstructive pulmonary disease patients who were admitted in the medicine department of a tertiary care hospital.
   Methods: A descriptive cross-sectional study was carried out in the medicine department of Nepal Medical College and teaching hospital between October 2009 and January 2010. Ethical approval was taken from the Intitutional Review Committee. Convenience sampling technique was used. All chronic obstructive pulmonary disease patients were included. Descriptive statistics were used to evaluate baseline characteristics. Point estimate at 90% Confidence Interval was calculated along with frequency and proportion for binary data.
   Results: Out of 84 patients, the period prevalence of metabolic syndrome is 30 (35.71%) (29.80-40.20 at 90% Confidence Interval) as per the definition by International Diabetes Federation 2006 for South Asians. Among them, 35 (41.67%) were male and 49 (58.33% ) were female. Eight (9.5%) were of age between 40-49 years, 11 (13.1%) between 50-59 years, 27 (32.1%) between 60-69 years and 38 (45.2%) of 70 years and above.
   Conclusions: The study showed that the prevalence of metabolic syndrome was found to be lower than the previous study done in similar settings.
C1 [Singh, Niraj Kumar] Nepal Med Coll Teaching Hosp, Dept Internal Med, Kathmandu, Nepal.
   [Karki, Lochan] Natl Acad Med Sci, Dept Med, Kathmandu, Nepal.
RP Singh, NK (corresponding author), Nepal Med Coll Teaching Hosp, Dept Internal Med, Kathmandu, Nepal.
EM drsinghniraj@gmail.com
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NR 10
TC 3
Z9 3
U1 0
U2 1
PU NEPAL MEDICAL ASSOC
PI KATHMANDU
PA NMA BUILDING, SIDDIHI SADAN, PO BOX 189, EXHIBITION RD, KATHMANDU,
   00000, NEPAL
SN 0028-2715
EI 1815-672X
J9 J NEPAL MED ASSOC
JI J. Nepal Med. Assoc.
PD APR
PY 2021
VL 59
IS 236
BP 313
EP 316
DI 10.31729/jnma.6410
PG 4
WC Public, Environmental & Occupational Health; Medicine, General &
   Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health; General & Internal Medicine
GA SI3GM
UT WOS:000654713600003
PM 34508521
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Moreira, FA
   Crippa, JAS
AF Moreira, Fabricio A.
   Crippa, Jose Alexandre S.
TI The psychiatric side-effects of rimonabant
SO REVISTA BRASILEIRA DE PSIQUIATRIA
LA English
DT Article
DE Cannabinoids; Drug effects; Anxiety; Depression; Obesity
ID CARDIOMETABOLIC RISK-FACTORS; RANDOMIZED CONTROLLED-TRIAL; CANNABINOID-1
   RECEPTOR BLOCKER; ENDOCANNABINOID SYSTEM; CB1 RECEPTOR; INVERSE AGONIST;
   WEIGHT-LOSS; ANANDAMIDE HYDROLYSIS; OVERWEIGHT PATIENTS; RIO-EUROPE
AB Objective: Experimental evidence has suggested that drugs that enhance cannabinoid type-1 (CB1) receptor activity may induce anxiolytic and antidepressant effects, whilst the opposite has been reported with antagonists. Thus, the objective of the present review is to discuss the potential psychiatric side-effects of CB1 receptor antagonists, such as rimonabant, which has been recently marketed in several countries for the treatment of smoking cessation, obesity and associated metabolic disorders. Method: Literature searches were performed in PubMed and SciELO databases up to February 2009. The terms searched were "obesity", "rimonabant", "cannabinoids", "unwanted effects", "diabetes", "smoking cessation" and "side-effects". Results: Clinical trials have revealed that rimonabant may promote weight loss in obese patients, although it may also induce symptoms of anxiety and depression. Discussion: Patients taking CB1 receptor antagonists should be carefully investigated for psychiatric side-effects. These drugs should not be prescribed for those already suffering from mental disorders. Nevertheless, the development of new compounds targeting the endocannabinoid system for the treatment of several conditions would be necessary and opportune.
C1 [Moreira, Fabricio A.] Univ Fed Minas Gerais, Inst Biol Sci, Dept Pharmacol, Belo Horizonte, MG, Brazil.
   [Crippa, Jose Alexandre S.] Univ Sao Paulo, Sch Med, Dept Behav Neurosci, BR-14049 Ribeirao Preto, Brazil.
   [Crippa, Jose Alexandre S.] Conselho Nacl Desenvolvimento Cientif & Tecnol, CNPq, INCT Translat Med, Campinas, SP, Brazil.
C3 Universidade Federal de Minas Gerais; Universidade de Sao Paulo
RP Crippa, JAS (corresponding author), Fac Med Ribeirao Preto, Dept Neurociencias & Ciencias Comportamento, Av Bandeirantes 3900, BR-14049900 Ribeirao Preto, Brazil.
EM jcrippa@fmrp.usp.br
RI de Souza Crippa, José/A-1215-2008
OI Moreira, Fabricio/0000-0002-0824-7302
FU Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq),
   Brasilia, Brazil
FX J. A. S. C is recipient of an Award for Research (1C) from Conselho
   Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq), Brasilia,
   Brazil.
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NR 63
TC 172
Z9 198
U1 0
U2 17
PU ASSOC BRASILEIRA PSIQUIATRIA
PI SAO PAULO
PA SUBSCRIPTION DEPARTMENT, RUA PEDRO DE TOLEDO, 967 - CASA 01, SAO PAULO,
   SP 04039-032  A, BRAZIL
SN 1516-4446
EI 1809-452X
J9 REV BRAS PSIQUIATR
JI Rev. Bras. Psiquiatr.
PD JUN
PY 2009
VL 31
IS 2
BP 145
EP 153
DI 10.1590/S1516-44462009000200012
PG 9
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 475HI
UT WOS:000268348800012
PM 19578688
OA Green Submitted, gold, Green Published
DA 2025-06-11
ER

PT J
AU Laugharne, J
   Waterreus, AJ
   Castle, DJ
   Dragovic, M
AF Laugharne, Jonathan
   Waterreus, Anna J.
   Castle, David J.
   Dragovic, Milan
TI Screening for the metabolic syndrome in Australia: a national survey of
   psychiatrists' attitudes and reported practice in patients prescribed
   antipsychotic drugs
SO AUSTRALASIAN PSYCHIATRY
LA English
DT Article
DE metabolic syndrome; screening; psychiatrists; Australia
ID MENTAL-HEALTH; PREVALENCE; CONSUMERS; RISK
AB Objective: To investigate current reported psychiatric practice in relation to screening for the metabolic syndrome in patients prescribed antipsychotic drugs within Australia.
   Method: A postal survey of all Fellows of the Royal Australian and New Zealand College of Psychiatrists. A 28-item questionnaire inquired into different aspects of screening and monitoring for metabolic syndrome in patients on antipsychotic medication.
   Results: Of 3123 questionnaires sent, 955 were returned. Of respondents, 55% had no established metabolic monitoring protocol or guidelines in their work place, with 13% saying they did not know what to monitor to detect metabolic syndrome. Altogether, 76% reported there was no reliable system in place to remind them when to monitor. Fewer than 50% of respondents routinely check weight, fasting glucose or lipids in their patients on antipsychotics and under than 30% checked blood pressure. Waist circumference was routinely checked in fewer than 7% of patients. Basic monitoring equipment was reported unavailable in more than 50% of clinical settings. However, more than 80% of respondents considered monitoring for metabolic syndrome to be their responsibility and 83% felt they had a medicolegal obligation in this respect.
   Conclusions: Routine screening for metabolic syndrome in patients on antipsychotic agents, by Australian psychiatrists, is inadequate. Interventions to improve screening rates need to be developed, implemented and evaluated.
C1 [Laugharne, Jonathan; Waterreus, Anna J.] Univ Western Australia, Sch Psychiat & Clin Neurosci, Perth, WA 6009, Australia.
   [Castle, David J.] St Vincents Hosp, Melbourne, NSW, Australia.
   [Castle, David J.] Univ Melbourne, Melbourne, NSW, Australia.
   [Dragovic, Milan] North Metropolitan Hlth Serv Mental Hlth, Clin Res Ctr, Perth, WA, Australia.
C3 University of Western Australia; NSW Health; St Vincents Hospital
   Sydney; University of Melbourne; North Metropolitan Health Service
RP Laugharne, J (corresponding author), Univ Western Australia, Sch Psychiat & Clin Neurosci, Level 6,W Block Fremantle Hosp, Fremantle, WA 6061, Australia.
EM jonathan.laugharne@uwa.edu.au
OI Castle, David/0000-0002-3075-1580; Waterreus, Anna/0000-0002-1648-7701
CR Barnes TRE, 2007, SCHIZOPHRENIA BULL, V33, P1397, DOI 10.1093/schbul/sbm038
   Bobes J, 2007, SCHIZOPHR RES, V90, P162, DOI 10.1016/j.schres.2006.09.025
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NR 21
TC 18
Z9 22
U1 0
U2 2
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1039-8562
EI 1440-1665
J9 AUSTRALAS PSYCHIATRY
JI Australas. Psychiatry
PD FEB
PY 2016
VL 24
IS 1
BP 62
EP 66
DI 10.1177/1039856215618521
PG 5
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA DD1GO
UT WOS:000369669500014
PM 26635377
DA 2025-06-11
ER

PT J
AU Mohammadi, S
   Fulop, T
   Khalil, A
   Ebrahimi, S
   Hasani, M
   Ziaei, S
   Farsi, F
   Mirtaheri, E
   Afsharianfar, M
   Heshmati, J
AF Mohammadi, Shooka
   Fulop, Tamas
   Khalil, Abdelouahed
   Ebrahimi, Sara
   Hasani, Motahareh
   Ziaei, Somayeh
   Farsi, Farnaz
   Mirtaheri, Elham
   Afsharianfar, Mostafa
   Heshmati, Javad
TI Does supplementation with pine bark extract improve cardiometabolic risk
   factors? A systematic review and meta-analysis
SO BMC COMPLEMENTARY MEDICINE AND THERAPIES
LA English
DT Review
DE Lipid profile; Glycemic parameters; Cardiometabolic syndrome; Oligopin;
   Pycnogenol; Flavangenol
ID DOUBLE-BLIND; OXIDATIVE STRESS; CARDIOVASCULAR-DISEASE; ENDOTHELIAL
   FUNCTION; METABOLIC SYNDROME; CLIMACTERIC SYNDROME; BLOOD-PRESSURE;
   PYCNOGENOL(R); ANTIOXIDANT; ENZOGENOL(R)
AB Background Supplementation with pine bark extract (PBE) may improve risk factors associated with cardiometabolic syndrome (CMS). The effects of PBE supplementation on cardiometabolic risk factors were evaluated in this systematic review and meta-analysis of randomized controlled trials (RCTs). Methods A comprehensive search of various databases was performed to identify relevant RCTs published up to September 2024. A random-effects model was employed for the meta-analysis, which included 27 RCTs with 1,685 participants. Results The findings indicated that PBE supplementation significantly reduced systolic blood pressure (SBP) (weighted mean difference (WMD): -2.26 mmHg, 95% confidence interval (CI): -3.73, -0.79; P = 0.003), diastolic blood pressure (DBP) (WMD: -2.62 mmHg, 95% CI: -3.71, -1.53; P < 0.001), fasting blood sugar (FBS) (WMD: -6.25 mg/dL, 95% CI: -9.97, -2.53; P = 0.001), hemoglobin A1c (HbA1c) (WMD: -0.32%, 95% CI: -0.54, -0.11; P = 0.003), body weight (WMD: -1.37 kg, 95% CI: -1.86, -0.88; P < 0.001), and low-density lipoprotein (LDL) cholesterol (WMD: -5.07 mg/dL, 95% CI: -9.21, -0.94; P = 0.016) in the PBE-treated group compared to their untreated counterparts. However, no significant impact of PBE was observed on waist-to-hip ratio (WHR), body mass index (BMI), waist circumference (WC), or serum levels of insulin, high-density lipoprotein (HDL) cholesterol, triglycerides (TG), and total cholesterol (TC). Conclusions Supplementation with PBE may ameliorate specific cardiometabolic risk factors, as indicated by reductions in body weight, DBP, SBP, FBS, LDL, and HbA1c levels. This approach can be regarded as an adjunct therapeutic strategy for CMS management. Further high-quality trials with larger sample sizes and longer durations are required to validate these findings.
C1 [Mohammadi, Shooka] Ahvaz Jundishapur Univ Med Sci, Nutr & Metab Dis Res Ctr, Ahvaz 6135715794, Iran.
   [Mohammadi, Shooka] Univ Malaya, Fac Med, Dept Social & Prevent Med, Kuala Lumpur, Malaysia.
   [Fulop, Tamas; Khalil, Abdelouahed] Univ Sherbrooke, Fac Med & Hlth Sci, Dept Med, Sherbrooke, PQ, Canada.
   [Ebrahimi, Sara] Hudson Inst Med Res, Ritchie Ctr, Clayton, Vic, Australia.
   [Hasani, Motahareh] Golestan Univ Med Sci, Sch Hlth, Dept Nutr Sci, Gorgan, Iran.
   [Ziaei, Somayeh] Kermanshah Univ Med Sci, Imam Reza Hosp, Dept Anesthesia, Kermanshah, Iran.
   [Farsi, Farnaz] Iran Univ Med Sci, Sch Publ Hlth, Dept Nutr, Tehran, Iran.
   [Mirtaheri, Elham] Tabriz Univ Med Sci, Fac Nutr & Food Sci, Dept Biochem & Dietet, Tabriz, Iran.
   [Afsharianfar, Mostafa] Isfahan Univ Med Sci, Dept Community Nutr, Sch Nutr & Food Sci, Esfahan, Iran.
   [Heshmati, Javad] Kermanshah Univ Med Sci, Sch Nutr Sci & Food Technol, Dept Nutr Sci, Kermanshah 6715847141, Iran.
C3 Ahvaz Jundishapur University of Medical Sciences (AJUMS); Universiti
   Malaya; University of Sherbrooke; Hudson Institute of Medical Research;
   Golestan University of Medical Sciences; Kermanshah University of
   Medical Sciences; Iran University of Medical Sciences; Tabriz University
   of Medical Science; Isfahan University of Medical Sciences; Kermanshah
   University of Medical Sciences
RP Mohammadi, S (corresponding author), Ahvaz Jundishapur Univ Med Sci, Nutr & Metab Dis Res Ctr, Ahvaz 6135715794, Iran.; Mohammadi, S (corresponding author), Univ Malaya, Fac Med, Dept Social & Prevent Med, Kuala Lumpur, Malaysia.; Heshmati, J (corresponding author), Kermanshah Univ Med Sci, Sch Nutr Sci & Food Technol, Dept Nutr Sci, Kermanshah 6715847141, Iran.
EM shooka.mohammadi@gmail.com; javad.heshmati@gmail.com
RI Hasani, Motahareh/AAY-8608-2020; heshmati, javad/H-6812-2019; Ebrahimi,
   Sara/ACQ-9831-2022; Mohammadi, Shooka/Y-2276-2018
OI Mohammadi, Shooka/0000-0001-9157-1922
NR 101
TC 0
Z9 0
U1 1
U2 1
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 2662-7671
J9 BMC COMPLEMENT MED
JI BMC Complement. Med. Ther.
PD FEB 22
PY 2025
VL 25
IS 1
AR 71
DI 10.1186/s12906-025-04819-9
PG 17
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA X9R6E
UT WOS:001428630500002
PM 39987124
OA gold
DA 2025-06-11
ER

PT J
AU Silveira, BKS
   de Novaes, JF
   Reis, ND
   Lourenço, LP
   Capobiango, AHM
   Vieira, SA
   Hermsdorff, HHM
AF Souza Silveira, Brenda Kelly
   de Novaes, Juliana Farias
   Reis, Ninive de Almeida
   Lourenco, Larissa Pereira
   Moretto Capobiango, Ana Helena
   Vieira, Sarah Aparecida
   Miranda Hermsdorff, Helen Hermana
TI "Traditional" and "Healthy" Dietary Patterns Are Associated with Low
   Cardiometabolic Risk in Brazilian Subjects
SO CARDIOLOGY RESEARCH AND PRACTICE
LA English
DT Article
ID ALL-CAUSE MORTALITY; OXIDATIVE STRESS; CARDIOVASCULAR-DISEASE; METABOLIC
   SYNDROME; FATTY-ACIDS; OLIVE OIL; POPULATION; CONSUMPTION; CHILDREN;
   VALIDITY
AB This study aimed at determining the dietary patterns and investigating their association with cardiometabolic risk markers in a brazilian population at risk.. is transversal study was carried out with data of 265 patients (n = 123 M/172 W, age 42 +/- 16 years) of the Cardiovascular Health Care Program-PROCARDIO-UFV, Brazil-who had their first appointment between 2012 and 2017. A 24-hour recall was applied the dietary patterns were determined by Principal Component Analysis. Anthropometric, clinical-metabolic, sociodemographic, and lifestyle data were collected through medical record analysis. Five patterns were identified: "Traditional", "Caloric", "Unhealthy", "Healthy," and "Healthy Snacks". In bivariate analysis, the "Healthy" pattern was negatively associated with WC (waist circunference), BMI (body mass index), WHR (waist-to-hip ratio), SBP (systolic blood pressure), fasting glucose, TG/HDL, LDL/HDL, and TG/HDL values and positively to HDL. The "Traditional"pattern was positively associated with adiposity indicators (WC, BMI, and WHR) and negatively associated with body fat, TyG (triglyceride-glucose index), HDL, and LDL (P < 0.05). However, in adjusted models of Poisson regression, individuals with positive factor score (higher adherence) in the "Traditional" and "Healthy" patterns had less occurrence of abdominal obesity (PR 0.85; 95% CI 0.74-0.99/PR 0.88; 95% CI 0.02-0.76), as well as dyslipidemia (PR 0.06; 95% CI 0.02-0.51/PR 0.03; 95% CI 0.01-0.27), diabetes (PR 0.05; 95% CI 0.01-0.45/PR 0.02; 95% CI 0.01-021), and hypertension (PR 0.06; 95% CI 0.02-0.50/PR 0.02; 95% CI 0.01-0.21). A greater adherence to the "Healthy" pattern was associated with lower values to cardiometabolic risk markers and less occurrence of chronic diseases, while the "Traditional"pattern presented contradictory results.
C1 [Souza Silveira, Brenda Kelly; de Novaes, Juliana Farias; Reis, Ninive de Almeida; Lourenco, Larissa Pereira; Moretto Capobiango, Ana Helena; Miranda Hermsdorff, Helen Hermana] Univ Fed Vicosa, Dept Nutr & Hlth, Vicosa, MG, Brazil.
   [Vieira, Sarah Aparecida] Univ Fed Espirito Santo, Dept Integrated Educ Hlth, Espirito Santo, Brazil.
C3 Universidade Federal de Vicosa; Universidade Federal do Espirito Santo
RP Hermsdorff, HHM (corresponding author), Univ Fed Vicosa, Dept Nutr & Hlth, Vicosa, MG, Brazil.
EM helenhermana@ufv.br
RI Hermsdorff, Helen Hermana Miranda/H-4525-2015
OI Hermsdorff, Helen Hermana Miranda/0000-0002-4441-6572; Souza Silveira,
   Brenda Kelly/0000-0003-3339-3747; Novaes, Juliana/0000-0003-3616-5096;
   Moretto Capobiango, Ana Helena/0000-0003-0348-4015; Vieira Ribeiro,
   Sarah Aparecida/0000-0002-0304-2711
FU CAPES Foundation [001]; National Council for Scientific and
   Technological Development (CNPq/MS/SCTIE/DECIT/SAS/DAB/CGAN)
   [408279/2017-6]; Foundation for Research Support of the State of Minas
   Gerais (FAPEMIG); CAPES (MEC/Brasil)
FX Financial support was provided by the CAPES Foundation (Finance code
   001), National Council for Scientific and Technological Development
   (CNPq/MS/SCTIE/DECIT/SAS/DAB/CGAN no. 408279/2017-6), and Foundation for
   Research Support of the State of Minas Gerais (FAPEMIG). HHM Hermsdorff
   is a CNPq Research Productivity fellow. We would like to thank all the
   professionals of the PROCARDIO-UFV for contributing in data collection
   and especially the volunteers for participating in the study. We would
   also like to thank CAPES (MEC/Brasil) for the master's scholarship
   granted to BKS Silveira.
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NR 71
TC 12
Z9 13
U1 0
U2 1
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2090-8016
EI 2090-0597
J9 CARDIOL RES PRACT
JI Cardiol. Res. Pract.
PY 2018
VL 2018
AR 4585412
DI 10.1155/2018/4585412
PG 11
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Cardiovascular System & Cardiology
GA HE2WR
UT WOS:000453211900001
PM 30581607
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Oviedo-Caro, MA
   Mayolas-Pi, C
   Bueno-Antequera, J
   Paris-García, F
   Murillo-Fuentes, A
   Reverter-Masia, J
   Munguía-Izquierdo, D
   Legaz-Arrese, A
AF Angel Oviedo-Caro, Miguel
   Mayolas-Pi, Carmen
   Bueno-Antequera, Javier
   Paris-Garcia, Federico
   Murillo-Fuentes, Alfonso
   Reverter-Masia, Joaquin
   Munguia-Izquierdo, Diego
   Legaz-Arrese, Alejandro
TI Training volume and amateur cyclists' health: a six-month follow-up from
   coinciding with a high-demand cycling event
SO RESEARCH IN SPORTS MEDICINE
LA English
DT Article
DE Exercise; endurance training; health; physical activity; physical
   performance
AB This study aimed to analyse the longitudinal association of amateur cycling training volume with health by comparing the proximity of participation in a high-demand cycling event. Variations in cycling training volume, behavioural cardiometabolic risk factors, and physical and psychosocial health were examined. Cyclists decreased their training volume by approximately 40% and their total physical activity volumes by approximately 20%, while controls maintained (similar to 5%). A time*group interaction was found for men's physical conditioning, body mass index and anxiety and, independent of gender, for behavioural cardiometabolic risk factors. Variation in cycling training volume was positively correlated with variation in physical conditioning and total physical activity and negatively correlated with variation in body mass index. The high level of cycling training volume developed at the time coinciding with a high demand cycling event predisposes to better physical health and behavioural cardiometabolic risk factors, without negatively affect psychosocial health, compared with six month later.
C1 [Angel Oviedo-Caro, Miguel; Bueno-Antequera, Javier; Munguia-Izquierdo, Diego] Univ Pablo de Olavide, Fac Sports Sci, Dept Sports & Comp Sci, Phys Performance & Sports Res Ctr,Sect Phys Educ, Seville, Spain.
   [Angel Oviedo-Caro, Miguel; Mayolas-Pi, Carmen; Bueno-Antequera, Javier; Paris-Garcia, Federico; Murillo-Fuentes, Alfonso; Reverter-Masia, Joaquin; Munguia-Izquierdo, Diego; Legaz-Arrese, Alejandro] Univ Zaragoza, Res Grp Dev Movimiento Humano, Zaragoza, Spain.
   [Mayolas-Pi, Carmen; Legaz-Arrese, Alejandro] Univ Zaragoza, Fac Hlth & Sport Sci, Dept Physiatry & Nursery, Sect Phys Educ & Sports, Zaragoza, Spain.
   [Paris-Garcia, Federico; Murillo-Fuentes, Alfonso] Univ Pablo de Olavide, Fac Sports Sci, Dept Sports & Comp Sci, Sect Phys Educ & Sports, Seville, Spain.
   [Reverter-Masia, Joaquin] Univ Lleida, Fac Educ Psychol & Social Work, Sect Phys Educ & Sports, Lleida, Spain.
   [Munguia-Izquierdo, Diego] Biomed Res Networking Ctr Frailty & Hlth Aging, Madrid, Spain.
   [Angel Oviedo-Caro, Miguel; Bueno-Antequera, Javier; Munguia-Izquierdo, Diego] Univ Pablo de Olavide, Fac Sports Sci, Dept Sports & Comp Sci, Seville 41013, Spain.
C3 Universidad Pablo de Olavide; University of Zaragoza; University of
   Zaragoza; Universidad Pablo de Olavide; Universitat de Lleida;
   Universidad Pablo de Olavide
RP Bueno-Antequera, J (corresponding author), Univ Pablo de Olavide, Fac Sports Sci, Dept Sports & Comp Sci, Seville 41013, Spain.
EM jbueant@upo.es
RI Reverter-Masia, Joaquin/H-5725-2012; Mayolas-Pi, Carmen/Y-2652-2018;
   Oviedo-Caro, Miguel/AAT-6933-2020; Munguía-Izquierdo, Diego/H-6452-2013;
   Bueno-Antequera, Javier/H-5515-2015; PARIS-GARCIA, FEDERICO/F-6853-2016
OI Oviedo-Caro, Miguel Angel/0000-0003-1032-0529; Bueno-Antequera,
   Javier/0000-0001-8063-3980; Mayolas Pi, Carmen/0000-0003-0721-2447;
   Munguia Izquierdo, Diego/0000-0001-7817-747X; PARIS-GARCIA,
   FEDERICO/0000-0002-7440-5719
FU Gobierno de Aragon [S25-D17]; FEDER Aragon 2014-2020 "Construyendo
   Europa desde Aragon"; Departamento de Innovacion, Investigacion y
   Universidad del Gobierno de Aragon y el Fondo Europeo de Desarrollo
   Regional -Programa Operativo FEDER Aragon 2014-2020 "Construyendo Europa
   desde Aragon" [PUI/2018-336, PUI/2018-337]; Spanish Ministry of
   Education [FPU13/05130]; Universidad de Lleida, Catedra ASISA [X18010];
   Biomedical Research Networking Center on Frailty and Healthy Aging
   (CIBERFES); FEDER funds from the European Union [CB16/10/00477]
FX The study was funded by Gobierno de Aragon (reference number S25-D17)
   and by FEDER Aragon 2014-2020 "Construyendo Europa desde Aragon". M.A.O.
   is supported by the Departamento de Innovacion, Investigacion y
   Universidad del Gobierno de Aragon y el Fondo Europeo de Desarrollo
   Regional -Programa Operativo FEDER Aragon 2014-2020 "Construyendo Europa
   desde Aragon" (reference number PUI/2018-336). J.B. is supported by the
   Spanish Ministry of Education (grant number FPU13/05130) and by the
   Departamento de Innovacion, Investigacion y Universidad del Gobierno de
   Aragon y el Fondo Europeo de Desarrollo Regional -Programa Operativo
   FEDER Aragon 2014-2020 "Construyendo Europa desde Aragon" (reference
   number PUI/2018-337). J.R. is supported by Universidad de Lleida,
   Catedra ASISA (reference number: X18010). D.M. is supported by the
   Biomedical Research Networking Center on Frailty and Healthy Aging
   (CIBERFES) and FEDER funds from the European Union (reference number
   CB16/10/00477). The funders had no role in study design; collection,
   analysis, and interpretation of data; writing the report; and the
   decision to submit the report for publication. There was no external
   financial support.
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NR 35
TC 0
Z9 0
U1 1
U2 11
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1543-8627
EI 1543-8635
J9 RES SPORTS MED
JI Res. Sports Med.
PD JUL 4
PY 2021
VL 29
IS 4
BP 373
EP 385
DI 10.1080/15438627.2020.1871349
EA JAN 2021
PG 13
WC Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Sport Sciences
GA SO3NO
UT WOS:000605057900001
PM 33401968
DA 2025-06-11
ER

PT J
AU Vigo, C
   Gatzemeier, W
   Sala, R
   Malacarne, M
   Santoro, A
   Pagani, M
   Lucini, D
AF Vigo, Chiara
   Gatzemeier, Wolfgang
   Sala, Roberto
   Malacarne, Mara
   Santoro, Armando
   Pagani, Massimo
   Lucini, Daniela
TI Evidence of altered autonomic cardiac regulation in breast cancer
   survivors
SO JOURNAL OF CANCER SURVIVORSHIP
LA English
DT Article
DE Cardiometabolic risk; Autonomic nervous system; Baroreflex sensitivity;
   Cardiorespiratory fitness; Lifestyle; Secondary prevention
ID VAGUS NERVE; METABOLIC SYNDROME; SPECTRAL-ANALYSIS; HEALTH-PROMOTION;
   HEART-RATE; DYSFUNCTION; EXERCISE; THERAPY; VARIABILITIES; MANAGEMENT
AB Purpose Surgery and adjuvant therapy improved prognosis of breast cancer survivors. This improvement risks being offset by potential late-occurring cardiovascular toxicity of oncologic treatment and increased cardiometabolic risk profile associated with lifestyle changes. We address the hypothesis that in breast cancer survivors, multiple functional alterations might define a phenotype, characterized by vagal impairment, diminished aerobic fitness, increased metabolic risk, and reduced wellbeing.
   MethodsWe studied 171 sedentary asymptomatic women (106 cancer survivor-65 controls) of similar age (53 +/- 8.6; 51 +/- 8.1 years). Autonomic regulation was evaluated by autoregressive spectral analysis of R wave to R wave (RR) interval and systolic arterial pressure variability. Aerobic fitness was directly assessed by cardiopulmonary exercise test. Body mass index (BMI) and waist circumference served as proxies of metabolism. Fatigue and stress-related symptoms were evaluated with validated questionnaire.
   ResultsPatients showed significantly smaller total RR variance (1644 +/- 2363 vs 2302 +/- 1561 msec(2)), smaller absolute power of low frequency (LF) (386 +/- 745 vs 810 +/- 1300 msec(2)) and high frequency (HF) (485 +/- 1202 vs 582 +/- 555 msec(2)) of RR interval variability and smaller spontaneous baroreflex sensitivity (15.0 +/- 8.9 vs 21.9 +/- 10 msec/mmHg), suggesting vagal impairment. VO2 peak and O-2 pulse were lower in cancer survivors than in controls. Fatigue and stress-related somatic symptoms scores were higher, as was BMI and waist circumference.
   Conclusion Breast cancer survivors show multiple dysfunctions: vagal impairment, lower aerobic fitness, signs of altered metabolism, and higher perception of fatigue.
C1 [Vigo, Chiara; Sala, Roberto; Malacarne, Mara; Pagani, Massimo; Lucini, Daniela] Univ Milan, BIOMETRA Dept, Milan, Italy.
   [Vigo, Chiara; Sala, Roberto; Malacarne, Mara; Lucini, Daniela] Humanitas Clin & Res Ctr, Exercise Med Unit, I-20089 Milan, Italy.
   [Gatzemeier, Wolfgang] Humanitas Canc Ctr, Breast Unit, Milan, Italy.
   [Santoro, Armando] Humanitas Clin & Res Ctr, Ctr Canc, Milan, Italy.
C3 University of Milan
RP Lucini, D (corresponding author), Humanitas Clin & Res Ctr, Exercise Med Unit, Via Alessandro Manzoni,Rozzano 56, I-20089 Milan, Italy.
EM daniela.lucini@unimi.it
RI Gatzemeier, Wolfgang/HMV-2117-2023; Santoro, Armando/J-9594-2018;
   Lucini, Daniela/ABD-7517-2021
OI Gatzemeier, Wolfgang/0000-0002-4026-0283; Santoro,
   Armando/0000-0003-1709-9492; Lucini, Daniela/0000-0003-4845-8988
CR [Anonymous], 2012, CANC FACTS FIG
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NR 36
TC 28
Z9 28
U1 3
U2 19
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1932-2259
EI 1932-2267
J9 J CANCER SURVIV
JI J. Cancer Surviv.-Res. Pract.
PD DEC
PY 2015
VL 9
IS 4
BP 699
EP 706
DI 10.1007/s11764-015-0445-z
PG 8
WC Oncology; Social Sciences, Biomedical
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Oncology; Biomedical Social Sciences
GA CV8UN
UT WOS:000364563500013
PM 25899303
DA 2025-06-11
ER

PT J
AU Leo, R
   Di Lorenzo, G
   Tesauro, M
   Cola, C
   Fortuna, E
   Zanasi, M
   Troisi, A
   Siracusano, A
   Lauro, R
   Romeo, F
AF Leo, Roberto
   Di Lorenzo, Giorgio
   Tesauro, Manfredi
   Cola, Clarissa
   Fortuna, Enzo
   Zanasi, Marco
   Troisi, Alfonso
   Siracusano, Alberto
   Lauro, Renato
   Romeo, Francesco
TI Decreased plasma adiponectin concentration in major depression
SO NEUROSCIENCE LETTERS
LA English
DT Article
DE adiponectin; depression; risk factors
ID CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; CARDIAC MORTALITY; RISK
AB Adiponectin is the most abundant adipose-derived plasma protein. Recently adiponectin levels have been linked to most variables of metabolic syndrome and conventional risk factors for cardiovascular disease. However, its relation with major depression is yet unclear. We evaluated plasma adiponectin levels in 32 first-episode drug-naive major depression (DSM-TV-TR) patients without conventional risk factors for cardiovascular disease and 32 matched healthy subjects. Major depression patients displayed lower adiponectin plasma levels compared to controls (P < 0.01). Adiponectin significantly correlated with depression severity, as assessed by HAM-D (rho=0.83, P < 0.001). This study shows decreased plasma adiponectin concentrations in major depression patients and relates adiponectinemia reduction to major depression severity. (c) 2006 Published by Elsevier Ireland Ltd.
C1 Univ Roma Tor Vergata, Dept Internal Med, Sch Med, Rome, Italy.
   Univ Roma Tor Vergata, Dept Neurosci, Sch Med, Rome, Italy.
C3 University of Rome Tor Vergata; University of Rome Tor Vergata
RP Leo, R (corresponding author), Univ Roma Tor Vergata, Dept Internal Med, Sch Med, Rome, Italy.
EM rtoleo@tiscali.it
RI TROISI, ALFONSO/AAB-8010-2019; Romeo, Francesco/GLN-4813-2022; Di
   Lorenzo, Giorgio/B-1308-2013
OI Di Lorenzo, Giorgio/0000-0002-0576-4064; TROISI,
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NR 14
TC 91
Z9 93
U1 0
U2 9
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0304-3940
J9 NEUROSCI LETT
JI Neurosci. Lett.
PD OCT 30
PY 2006
VL 407
IS 3
BP 211
EP 213
DI 10.1016/j.neulet.2006.08.043
PG 3
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 097PY
UT WOS:000241461600005
PM 16973279
DA 2025-06-11
ER

PT S
AU Steptoe, A
   Kivimäki, M
AF Steptoe, Andrew
   Kivimaeki, Mika
BE Fielding, JE
TI Stress and Cardiovascular Disease: An Update on Current Knowledge
SO ANNUAL REVIEW OF PUBLIC HEALTH, VOL 34
SE Annual Review of Public Health
LA English
DT Review; Book Chapter
DE work stress; social isolation; emotional triggering; coronary heart
   disease; hypertension
ID CORONARY-HEART-DISEASE; ACUTE MYOCARDIAL-INFARCTION; AMBULATORY
   BLOOD-PRESSURE; LONG-TERM MORTALITY; JOB STRAIN; METABOLIC SYNDROME;
   MENTAL STRESS; SOCIOECONOMIC POSITION; RISK-FACTORS; PSYCHOLOGICAL
   STRESS
AB Considerable progress has been made during the past decade in research on cardiovascular effects of stress. Early-life stressors, such as childhood abuse and early socioeconomic adversity, are linked to increased cardiovascular morbidity in adulthood. Our updated meta-analyses of prospective studies published until 2011 show a 1.5-fold (95% confidence interval 1.2-1.9) increased risk of coronary heart disease among adults experiencing social isolation and a 1.3-fold (1.2-1.5) excess risk for workplace stress; adverse metabolic changes are one of the underlying plausible mechanisms. Stress, anger, and depressed mood can act as acute triggers of major cardiac events; the pooled relative risk of acute coronary syndrome onset being preceded by stress is 2.5 (1.8-3.5) in case-crossover studies. Stress is also implicated in the prognosis of cardiovascular disease and in the development of stress (takotsubo) cardiomyopathy. A major challenge over the next decade is to incorporate stress processes into the mainstream of cardiovascular pathophysiological research and understanding.
C1 [Steptoe, Andrew; Kivimaeki, Mika] UCL, Dept Epidemiol & Publ Hlth, London WC1E 6BT, England.
C3 University of London; University College London
RP Steptoe, A (corresponding author), UCL, Dept Epidemiol & Publ Hlth, Mortimer St, London WC1E 6BT, England.
EM a.steptoe@ucl.ac.uk; m.kivimaki@ucl.ac.uk
RI Kivimaki, Mika/B-3607-2012; Steptoe, Andrew/Y-2440-2019
OI Steptoe, Andrew/0000-0001-7808-4943; Kivimaki, Mika/0000-0002-4699-5627
FU ESRC [ES/J023299/1] Funding Source: UKRI; MRC [MR/K013351/1] Funding
   Source: UKRI; British Heart Foundation [RG/10/005/28296] Funding Source:
   Medline; Medical Research Council [MR/K013351/1] Funding Source:
   Medline; NHLBI NIH HHS [R01HL036310] Funding Source: Medline; NIA NIH
   HHS [R01AG034454] Funding Source: Medline
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NR 149
TC 522
Z9 596
U1 9
U2 202
PU ANNUAL REVIEWS
PI PALO ALTO
PA 4139 EL CAMINO WAY, PO BOX 10139, PALO ALTO, CA 94303-0897 USA
SN 0163-7525
BN 978-0-8243-2734-7
J9 ANNU REV PUBL HEALTH
JI Annu. Rev. Public Health
PY 2013
VL 34
BP 337
EP +
DI 10.1146/annurev-publhealth-031912-114452
PG 21
WC Public, Environmental & Occupational Health
WE Book Citation Index – Social Sciences & Humanities (BKCI-SSH); Book Citation Index – Science (BKCI-S); Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA BFY40
UT WOS:000321892700022
PM 23297662
DA 2025-06-11
ER

PT J
AU Muhtz, C
   Godemann, K
   von Alm, C
   Wittekind, C
   Goemann, C
   Wiedemann, K
   Yassouridis, A
   Kellner, M
AF Muhtz, Christoph
   Godemann, Kathrin
   von Alm, Christine
   Wittekind, Charlotte
   Goemann, Christoph
   Wiedemann, Klaus
   Yassouridis, Alexander
   Kellner, Michael
TI Effects of Chronic Posttraumatic Stress Disorder on Metabolic Risk,
   Quality of Life, and Stress Hormones in Aging Former Refugee Children
SO JOURNAL OF NERVOUS AND MENTAL DISEASE
LA English
DT Article
DE Posttraumatic stress disorder; metabolic syndrome; ankle-brachial index;
   life quality; stress; trauma; cortisol
ID PITUITARY-ADRENAL AXIS; WORLD-WAR-II; REPORTED HEALTH-PROBLEMS;
   HOLOCAUST SURVIVORS; PHYSICAL ILLNESS; VIETNAM VETERANS; MENTAL-HEALTH;
   PRIMARY-CARE; PTSD; TRAUMA
AB It is still unclear whether the association between traumatic stress and physical disease is mediated by posttraumatic stress disorder (PTSD). Therefore, we examined the long-term consequences of PTSD on cardiovascular risk, stress hormones, and quality of life in a sample of former refugee children who were severely traumatized more than six decades ago. In 25 subjects with chronic PTSD and 25 trauma-controlled subjects, we measured the variables of metabolic syndrome supplemented by the ankle-brachial index and highly sensitive C-reactive protein. Quality of life was assessed using the 36-item Short-Form Health Survey. Cortisol, adrenocorticotropin-releasing hormone (ACTH), and dehydroepiandrosterone (DHEA) were measured using the low-dose-dexamethasone suppression test. In addition, salivary cortisol was assessed at 8: 00 a. m., 12: 00 p. m., 4: 00 p. m., and 8: 00 p. m. We found a significant group effect between participants with and without PTSD regarding quality of life but not in any metabolic parameter including the ankle-brachial index or cortisol, ACTH, and DHEA in plasma before and after dexamethasone or salivary cortisol. The postulated association between traumatic stress and physical illness does not appear to be mediated by PTSD in this population. Nevertheless, the search for subgroups of PTSD patients with childhood traumatization leading to different metabolic and endocrine long-term consequences in aging PTSD patients is needed.
C1 [Muhtz, Christoph; Godemann, Kathrin; von Alm, Christine; Wittekind, Charlotte; Goemann, Christoph; Wiedemann, Klaus; Kellner, Michael] Univ Hosp Hamburg Eppendorf, Dept Psychiat & Psychotherapy, D-20246 Hamburg, Germany.
   [Yassouridis, Alexander] Max Planck Inst Psychiat, D-80804 Munich, Germany.
C3 University of Hamburg; University Medical Center Hamburg-Eppendorf; Max
   Planck Society
RP Muhtz, C (corresponding author), Univ Hosp Hamburg Eppendorf, Dept Psychiat & Psychotherapy, Martinistr 52, D-20246 Hamburg, Germany.
EM cmuhtz@uke.uni-hamburg.de
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   Yehuda R, 2006, BIOL PSYCHIAT, V60, P714, DOI 10.1016/j.biopsych.2006.03.069
NR 77
TC 34
Z9 36
U1 0
U2 28
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0022-3018
EI 1539-736X
J9 J NERV MENT DIS
JI J. Nerv. Ment. Dis.
PD SEP
PY 2011
VL 199
IS 9
BP 646
EP 652
DI 10.1097/NMD.0b013e318229cfba
PG 7
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA 814JT
UT WOS:000294447300006
PM 21878777
DA 2025-06-11
ER

PT J
AU Doggrell, SA
AF Doggrell, Sheila A.
TI Is rimonabant efficacious and safe in the treatment of obesity?
SO EXPERT OPINION ON PHARMACOTHERAPY
LA English
DT Review
DE atherosclerosis; clinical trials; obesity; rimonabant; RIO;
   STRADIVARIUS; weight loss
ID CARDIOMETABOLIC RISK-FACTORS; WEIGHT
AB Background: The incidence of obesity is increasing worldwide, and in the USA approximately 100 million adults are overweight or obese. Orlistat and sibutramine are the drugs used at present for weight loss, but they both have a relatively modest effect. Objectives/methods: This evaluation is of the Rimonabant in Obesity (RIO) programme of clinical trials, and of the first trial to determine whether rimonabant has any effect on a clinical outcome. The Strategy to Reduce Atherosclerosis Development involving Administration of Rimonabant - the Intravascular Ultrasound Study (STRADIVARIUS) determined whether treatment with rimonabant decreased atherosclerosis. Results: The individual trials of the RIO programme showed that rimonabant 20 mg caused body weight loss, and also caused small decreases in waist circumference, plasma triglycerides and fasting glucose levels, and the incidence of the metabolic syndrome, while increasing levels of HDL cholesterol. Gastrointestinal side effects were the most common reported in the individual trials. However, when the five trials were combined, a small but significant increase in the incidence of depression and anxiety became apparent with rimonabant 20 mg. STRADIVARIUS showed that rimonabant 20 mg had no effect on atherosclerosis that was not progressing in subjects who were mostly also taking antithrombotic agents, statins, beta-blockers and angiotensin inhibitors. Conclusions: At present, it is doubtful whether the benefits of rimonabant outweigh the risks. Unless rimonabant is shown to have benefits in ongoing clinical outcome studies, there is little rationale to support its use in the treatment of obesity.
C1 RMIT Univ, Sch Med Sci, Discipline Pharmaceut Sci, Bundoora, Vic 3083, Australia.
C3 Royal Melbourne Institute of Technology (RMIT)
RP Doggrell, SA (corresponding author), RMIT Univ, Sch Med Sci, Discipline Pharmaceut Sci, Bundoora, Vic 3083, Australia.
EM sheila.doggrell@rmit.edu.au
OI Doggrell, Sheila/0000-0002-0942-0795
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   ATHEROSCLEROSIS UNDE
   COMPREHENSIVE RIMONB
NR 13
TC 22
Z9 23
U1 1
U2 12
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1465-6566
EI 1744-7666
J9 EXPERT OPIN PHARMACO
JI Expert Opin. Pharmacother.
PD OCT
PY 2008
VL 9
IS 15
BP 2727
EP 2731
DI 10.1517/14656566.9.15.2727
PG 5
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 361MW
UT WOS:000260132800015
PM 18803459
DA 2025-06-11
ER

PT J
AU Shenhar-Tsarfaty, S
   Toker, S
   Shapira, I
   Rogowski, O
   Berliner, S
   Ritov, Y
   Soreq, H
AF Shenhar-Tsarfaty, Shani
   Toker, Sharon
   Shapira, Itzhak
   Rogowski, Ori
   Berliner, Shlomo
   Ritov, Yaacov
   Soreq, Hermona
TI Weakened Cholinergic Blockade of Inflammation Associates with
   Diabetes-Related Depression
SO MOLECULAR MEDICINE
LA English
DT Article
ID C-REACTIVE PROTEIN; VAGUS NERVE; ACETYLCHOLINESTERASE; MELLITUS; ANXIETY
AB Emerging evidence demonstrates association of depression with both immune malfunctioning and worsened course of diverse aging-related diseases, but there is no explanation for the pathway(s) controlling this dual association. Here, we report that in post-reproductive and evolutionarily "blind" years, depression may weaken pathogen-host defense, compatible with the - antagonistic pleiotropy hypothesis. In 15,532 healthy volunteers, depression scores associated with both inflammatory parameters and with increased circulation cholinesterase activities, implicating debilitated cholinergic blockade of inflammation as an underlying mechanism; furthermore, depression, inflammation and cholinesterase activities all increased with aging. In the entire cohort, combined increases in inflammation and the diabetic biomarker hemoglobin Alc associated with elevated depression. Moreover, metabolic syndrome patients with higher risk of diabetes showed increased cholinesterase levels and pulse values, and diabetic patients presented simultaneous increases in depression, inflammation and circulation cholinesterase activities, suggesting that cholinergic impairment precedes depression. Our findings indicate that dysfunctioning cholinergic regulation weakens the otherwise protective link between depression and pathogen-host defense, with global implications for aging-related diseases.
C1 [Shenhar-Tsarfaty, Shani; Soreq, Hermona] Hebrew Univ Jerusalem, Edmond & Lily Safra Ctr Brain Sci, IL-91905 Jerusalem, Israel.
   [Shenhar-Tsarfaty, Shani; Soreq, Hermona] Hebrew Univ Jerusalem, Alexander Silberman Inst Life Sci, IL-91905 Jerusalem, Israel.
   [Toker, Sharon; Rogowski, Ori; Berliner, Shlomo] Tel Aviv Univ, Fac Management, IL-69978 Tel Aviv, Israel.
   [Shapira, Itzhak] Tel Aviv Sourasky Med Ctr, Dept Internal Med, Tel Aviv, Israel.
   [Ritov, Yaacov] Hebrew Univ Jerusalem, Dept Stat, IL-91905 Jerusalem, Israel.
   [Ritov, Yaacov] Hebrew Univ Jerusalem, Ctr Rat, IL-91905 Jerusalem, Israel.
C3 Hebrew University of Jerusalem; Hebrew University of Jerusalem; Tel Aviv
   University; Tel Aviv University; Sackler Faculty of Medicine; Tel Aviv
   Sourasky Medical Center; Hebrew University of Jerusalem; Hebrew
   University of Jerusalem
RP Soreq, H (corresponding author), Hebrew Univ Jerusalem, Edmond & Lily Safra Ctr Brain Sci, IL-91905 Jerusalem, Israel.; Soreq, H (corresponding author), Hebrew Univ Jerusalem, Alexander Silberman Inst Life Sci, IL-91905 Jerusalem, Israel.
EM hermona.soreq@mail.huji.ac.il
RI Soreq, Hermona/AFM-0869-2022; Ritov, Yaacov/JPX-2841-2023; Toker,
   Sharon/P-5428-2015
OI Soreq, Hermona/0000-0002-0955-526X; Shenhar-Tsarfaty,
   Shani/0000-0002-8268-1799; Toker, Sharon/0000-0001-7621-6607
FU Legacy Heritage Biomedical Partnership Program of the Israel Science
   Foundation [1799/10]; German Research Foundation Trilateral Cooperation
   Program; I-Core program of the Planning and Budgeting Committee Center
   of Excellence on Mass Trauma; Israel Science Foundation [1916/12];
   European Commission [602133]; Israel Science Foundation; Edmond and Lily
   Safra Center for Brain Sciences
FX This study was supported by the Legacy Heritage Biomedical Partnership
   Program of the Israel Science Foundation (Grant No 1799/10), the German
   Research Foundation Trilateral Cooperation Program, the I-Core program
   of the Planning and Budgeting Committee Center of Excellence on Mass
   Trauma and the Israel Science Foundation (Center No. 1916/12), the
   European Commission grant number 602133 - ncRNA Pain (to HS), the Israel
   Science Foundation (to YR) and The Edmond and Lily Safra Center for
   Brain Sciences, which awarded SS-T a post-doctoral fellowship.
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NR 39
TC 23
Z9 23
U1 0
U2 2
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1076-1551
EI 1528-3658
J9 MOL MED
JI Mol. Med.
PY 2016
VL 22
BP 156
EP 161
DI 10.2119/molmed.2016.00067
PG 6
WC Biochemistry & Molecular Biology; Cell Biology; Medicine, Research &
   Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology; Research & Experimental
   Medicine
GA DT5LA
UT WOS:000381523500001
PM 27257683
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Fond, G
   Faugere, M
   Faget-Agius, C
   Cermolacce, M
   Richieri, R
   Boyer, L
   Lancon, C
AF Fond, G.
   Faugere, M.
   Faget-Agius, C.
   Cermolacce, M.
   Richieri, R.
   Boyer, L.
   Lancon, C.
TI Hypovitaminosis D is associated with negative symptoms, suicide risk,
   agoraphobia, impaired functional remission, and antidepressant
   consumption in schizophrenia
SO EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
LA English
DT Article
DE Vitamin D; Schizophrenia; Depression; Anxiety; Metabolic syndrome;
   Antidepressant; Agoraphobia; Suicide risk
ID LOW VITAMIN-D; METABOLIC SYNDROME; DEPRESSIVE SYMPTOMS; D
   SUPPLEMENTATION; D DEFICIENCY; DISORDERS; PREVALENCE; VALIDATION;
   ALCOHOL
AB Hypovitaminosis D has been associated with, respectively, major depressive disorder, schizophrenia (SZ), and cognitive disorders in the general population, and with positive and negative symptoms and metabolic syndrome in schizophrenia. The objective was to determine the prevalence of hypovitaminosis D and associated factors in a non-selected multicentric sample of SZ subjects in day hospital. Hypovitaminosis D was defined by blood vitamin D level < 25 nM. Depressive symptoms were assessed by the Calgary Depression Rating Scale Score and Positive and Negative Syndrome Scale Score. Anxiety disorders and suicide risk were evaluated by the Structured Clinical Interview for Mental Disorders. Functioning was evaluated with the Functional Remission of General Schizophrenia Scale. Hypovitaminosis D has been found in 27.5% of the subjects. In multivariate analysis, hypovitaminosis D has been significantly associated with, respectively, higher suicide risk (aOR = 2.67 [1.31-5.46], p = 0.01), agoraphobia (aOR = 3.37 [1.66-6.85], p < 0.0001), antidepressant consumption (aOR = 2.52 [1.37-4.64], p < 0.001), negative symptoms (aOR = 1.04 [1.01-1.07], p = 0.04), decreased functioning (aOR = 0.97[0.95-0.99], p = 0.01), and increased leucocytosis (aOR = 1.17 [1.04-1.32], p = 0.01) independently of age and gender. No association with alcohol use disorder, metabolic syndrome, peripheral inflammation, insulin resistance, or thyroid disturbances has been found (all p > 0.05). Despite some slight abnormalities, no major cognitive impairment has been associated with hypovitaminosis D in the present sample (all p > 0.05 except for WAIS similarities score). Hypovitaminosis D is frequent and associated with suicide risk, agoraphobia and antidepressant consumption in schizophrenia, and more slightly with negative symptoms. Patients with agoraphobia, suicide risk and antidepressant consumption may, therefore, benefit in priority from vitamin D supplementation, given the benefit/risk profile of vitamin D. Further studies should evaluate the impact of vitamin D supplementation on clinical outcomes of SZ subjects.
C1 [Fond, G.; Faugere, M.; Faget-Agius, C.; Cermolacce, M.; Richieri, R.; Boyer, L.; Lancon, C.] La Conception Univ Hosp, Dept Psychiat, F-13005 Marseille, France.
   [Fond, G.; Faugere, M.; Faget-Agius, C.; Cermolacce, M.; Richieri, R.; Boyer, L.; Lancon, C.] Aix Marseille Univ, Fac Med, Sect Timone, EA 3279,CEReSS Ctr Etud & Rech Serv Sante & Quali, 27 Blvd Jean Moulin, F-13005 Marseille, France.
   [Fond, G.; Faugere, M.; Faget-Agius, C.; Cermolacce, M.; Richieri, R.; Boyer, L.; Lancon, C.] St Marguerite Univ Hosp, SHU Adult Psychiat, F-13274 Marseille, France.
C3 Aix-Marseille Universite; Aix-Marseille Universite; Aix-Marseille
   Universite; Assistance Publique-Hopitaux de Marseille
RP Fond, G (corresponding author), La Conception Univ Hosp, Dept Psychiat, F-13005 Marseille, France.; Fond, G (corresponding author), Aix Marseille Univ, Fac Med, Sect Timone, EA 3279,CEReSS Ctr Etud & Rech Serv Sante & Quali, 27 Blvd Jean Moulin, F-13005 Marseille, France.; Fond, G (corresponding author), St Marguerite Univ Hosp, SHU Adult Psychiat, F-13274 Marseille, France.
EM guillaume.fond@ap-hm.fr
RI Faugere, Melanie/JCP-3459-2023; Fond, Guillaume/D-7646-2011; richieri,
   raphaelle/E-4707-2015; Boyer, Laurent/E-5728-2016
OI RICHIERI, Raphaelle/0000-0002-3901-7016
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NR 41
TC 14
Z9 16
U1 0
U2 17
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0940-1334
EI 1433-8491
J9 EUR ARCH PSY CLIN N
JI Eur. Arch. Psych. Clin. Neurosci.
PD DEC
PY 2019
VL 269
IS 8
BP 879
EP 886
DI 10.1007/s00406-018-0932-0
PG 8
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA JL2XG
UT WOS:000495394500003
PM 30078128
DA 2025-06-11
ER

PT J
AU Jespersen, L
   Abildstrom, SZ
   Hvelplund, A
   Prescott, E
AF Jespersen, Lasse
   Abildstrom, Steen Z.
   Hvelplund, Anders
   Prescott, Eva
TI Persistent angina: highly prevalent and associated with long-term
   anxiety, depression, low physical functioning, and quality of life in
   stable angina pectoris
SO CLINICAL RESEARCH IN CARDIOLOGY
LA English
DT Article
DE Stable angina; Anxiety; Depression; Coronary artery disease; Quality of
   life
ID CORONARY-ARTERY-DISEASE; ISCHEMIA SYNDROME EVALUATION; CHEST-PAIN;
   CARDIOVASCULAR EVENTS; MYOCARDIAL-INFARCTION; GENDER-DIFFERENCES;
   HEART-DISEASE; SYNDROME-X; FOLLOW-UP; WOMEN
AB To evaluate persistent angina in stable angina pectoris with no obstructive coronary artery disease (CAD) compared to obstructive CAD and its relation to long-term anxiety, depression, quality of life (QOL), and physical functioning.
   We invited 357 patients (men = 191; women = 166; response rate 83 %) with no prior cardiovascular disease who had a first-time coronary angiography (CAG) in 2008-2009 due to suspected stable angina to participate in a questionnaire survey in 2011 with the Seattle Angina Questionnaire and the Hospital Anxiety and Depression Scale as key elements. Long-term persistent angina (i.e., symptoms at least once a month) was present in 64 % of patients with diffuse non-obstructive CAD (1-49 % stenosis), 49 % of patients with normal coronary arteries (0 % stenosis), and 41 % of patients with obstructive CAD (a parts per thousand yen50 % stenosis) (P = 0.01). Depression and anxiety were more common in patients with persistent angina: 24 versus 7 % (P < 0.001) reported HADS-Depression-scores > 7 and 42 versus 21 % (P < 0.001) reported HADS-Anxiety-scores > 7. In multivariate regression models, persistent angina was associated with depression (OR 4.3, 95 % confidence interval (CI) 1.9-9.6, P < 0.001), anxiety (OR 2.9, 95 % CI 1.6-5.1, P < 0.001), the severity of persistent angina with impaired physical functioning (P < 0.001), and QOL (P < 0.001); whereas outcomes were not related to age, gender, or degree of CAD.
   The study indicates higher prevalence of persistent angina in patients with diffuse non-obstructive CAD or normal coronary arteries than in patients with obstructive CAD. Persistent angina symptoms were associated with long-term anxiety, depression, impaired physical functioning, and QOL irrespective of the degree of CAD. Contrary to common perception, excluding obstructive CAD in stable angina does not ensure a favorable disease course, and further risk stratification and treatment strategies are warranted.
C1 [Jespersen, Lasse; Abildstrom, Steen Z.; Prescott, Eva] Bispebjerg Hosp, Dept Cardiol, DK-2400 Copenhagen, Denmark.
   [Hvelplund, Anders] Univ Southern Denmark, Natl Inst Publ Hlth, DK-1399 Copenhagen, Denmark.
   [Hvelplund, Anders] Gentofte Univ Hosp, Dept Cardiol, DK-2900 Hellerup, Denmark.
C3 University of Copenhagen; Copenhagen University Hospital; Bispebjerg
   Hospital; University of Southern Denmark; University of Copenhagen;
   Herlev & Gentofte Hospital
RP Jespersen, L (corresponding author), Bispebjerg Hosp, Dept Cardiol, Bispebjerg Bakke 23, DK-2400 Copenhagen, Denmark.
EM lasjes@gmail.com
RI Prescott, Eva/AAJ-7441-2020
OI Prescott, Eva/0000-0002-4134-0349
FU The Danish Heart Foundation [11-04-R83-A3257-22621]
FX This work was supported by The Danish Heart Foundation
   (11-04-R83-A3257-22621).
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NR 26
TC 117
Z9 123
U1 1
U2 19
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1861-0684
J9 CLIN RES CARDIOL
JI Clin. Res. Cardiol.
PD AUG
PY 2013
VL 102
IS 8
BP 571
EP 581
DI 10.1007/s00392-013-0568-z
PG 11
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 185JZ
UT WOS:000321965200004
PM 23636227
DA 2025-06-11
ER

PT J
AU Fibbins, H
   Ward, PB
   Curtis, J
   Watkins, A
   Lederman, O
   Morell, R
   Rosenbaum, S
AF Fibbins, Hamish
   Ward, Philip B.
   Curtis, Jackie
   Watkins, Andrew
   Lederman, Oscar
   Morell, Rachel
   Rosenbaum, Simon
TI Effectiveness of a brief lifestyle intervention targeting mental health
   staff: analysis of physical fitness and activity in the Keeping Our
   Staff in Mind study
SO BMJ OPEN SPORT & EXERCISE MEDICINE
LA English
DT Article
DE exercise; mental; illness; physical activity
ID CARDIORESPIRATORY FITNESS; EXERCISE INTERVENTIONS; PSYCHOTIC DISORDERS;
   EXCESS MORTALITY; ILLNESS; PEOPLE; METAANALYSIS; SCHIZOPHRENIA; DISEASE;
   CARE
AB BackgroundPeople with mental illness die on average 15 years less than the general population, primarily to cardiometabolic disease. Lifestyle interventions are effective in reducing cardiometabolic risk but are not routinely provided to mental health consumers. Lifestyle interventions targeting mental health staff may be beneficial in changing culture surrounding physical health and subsequently improving consumer outcomes. This study examines exercise and fitness outcomes of a targeted lifestyle intervention directed at Australian mental health staff.MethodsA pragmatic single-arm intervention study was conducted within an Australian public mental health service. Mental health staff were provided a five-session individualised lifestyle intervention (incorporating exercise and nutritional counselling) over 5 weeks. Two waves of the programme were delivered between 2015 and 2016. This paper examines the exercise and fitness outcomes of the second wave of the study. Participants were assessed at baseline and at a 16-week follow-up. The primary exercise outcome was a measurement of cardiorespiratory fitness. Secondary outcomes included self-reported physical activity and a measurement of handgrip strength.ResultsA total of 106 staff participated in this component of the study. Cardiorespiratory fitness increased significantly from baseline to follow-up (p<0.001). Significant improvements to physical activity occurred with decreases in sedentary time (p<0.0005) and increases in moderate-to-vigorous physical activity (p<0.005).ConclusionLifestyle interventions incorporating exercise counselling may improve the physical health of mental health staff. Such strategies may be effective in improving culture surrounding physical health and/or increasing the effectiveness of lifestyle interventions targeting mental health consumers.
C1 [Fibbins, Hamish; Ward, Philip B.; Curtis, Jackie; Morell, Rachel; Rosenbaum, Simon] Univ New South Wales, Sch Psychiat, Sydney, NSW, Australia.
   [Fibbins, Hamish; Curtis, Jackie; Watkins, Andrew; Lederman, Oscar] South Eastern Sydney Local Hlth Dist, Keeping Body Mind Program, Sydney, NSW, Australia.
   [Ward, Philip B.] Liverpool Hosp, Schizophrenia Res Unit, Sydney, NSW, Australia.
   [Ward, Philip B.] Ingham Inst Appl Med Res, Sydney, NSW, Australia.
   [Watkins, Andrew] Univ Technol Sydney, Fac Hlth, Sydney, NSW, Australia.
   [Lederman, Oscar] Univ New South Wales, Sch Med Sci, Sydney, NSW, Australia.
   [Rosenbaum, Simon] Black Dog Inst, Randwick, NSW, Australia.
C3 University of New South Wales Sydney; South Eastern Sydney Local Health
   District; Liverpool Hospital; Ingham Institute for Applied Medical
   Research; University of Technology Sydney; University of New South Wales
   Sydney; Black Dog Institute
RP Fibbins, H (corresponding author), Univ New South Wales, Sch Psychiat, Sydney, NSW, Australia.; Fibbins, H (corresponding author), South Eastern Sydney Local Hlth Dist, Keeping Body Mind Program, Sydney, NSW, Australia.
EM hamish.fibbins@health.nsw.gov.au
RI Rosenbaum, Simon/Y-3241-2019; Curtis, Jackie/J-5789-2019; Fibbins,
   Hamish/KLZ-4932-2024; Ward, Philip/JCE-6293-2023
OI Lederman, Oscar/0000-0002-0321-5723; Morell, Rachel/0000-0003-3065-5318;
   Ward, Philip/0000-0002-5779-7722; Curtis, Jackie/0000-0001-6884-0098;
   Watkins, Andrew/0000-0003-3452-8682; Rosenbaum,
   Simon/0000-0002-8984-4941; Fibbins, Hamish/0000-0002-2673-7866
FU District Mental Health programme; District Mental Health programme;
   South Eastern Sydney Local Health District, Sydney
FX This project was funded by the District Mental Health programme; South
   Eastern Sydney Local Health District, Sydney.
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NR 48
TC 5
Z9 6
U1 1
U2 9
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2398-9459
EI 2055-7647
J9 BMJ OPEN SPORT EXERC
JI BMJ Open Sport Exerc. Med.
PY 2020
VL 6
IS 1
AR e000761
DI 10.1136/bmjsem-2020-000761
PG 7
WC Sport Sciences
WE Emerging Sources Citation Index (ESCI)
SC Sport Sciences
GA PF6QA
UT WOS:000599175200003
PM 32685186
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Chirinos, DA
   Murdock, KW
   Leroy, AS
   Fagundes, C
AF Chirinos, Diana A.
   Murdock, Kyle W.
   LeRoy, Angie S.
   Fagundes, Christopher
TI Depressive symptom profiles, cardio-metabolic Results from the MIDUS
   study
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE Depression; Metabolic syndrome; Obesity; Inflammation; Lipoproteins;
   Blood pressure; Hyperglycemia; Latent class analysis
ID NUTRITION EXAMINATION SURVEY; CARDIOVASCULAR-DISEASE; BIDIRECTIONAL
   ASSOCIATION; COGNITIVE SYMPTOMS; NATIONAL-HEALTH; EVENTS; RISK;
   METAANALYSIS; MORTALITY; ANXIETY
AB Background: This study aimed to (1) provide a comprehensive characterization of depressive symptoms profiles, and (2) examine the cross-sectional association between depressive symptom profiles and cardio-metabolic outcomes, including metabolic syndrome and obesity, while controlling for sociodemographic variables, health behaviors and inflammation.
   Methods: Our sample was comprised of 1085 participants (55.80% female) enrolled in the MIDUS-II biomarker study. Latent profile analysis (LPA) was used to derive depressive symptom profiles using subscales of the Mood and Anxiety Symptom Questionnaire (MASQ) and the Center for Epidemiologic Studies Depression Scale (CES-D) subscales as well as Pittsburgh Sleep Quality Index (PSQI) global score. Metabolic syndrome was defined according to the Interim Joint Statement definition. CRP was used as a marker of inflammation.
   Results: Four depressive symptom profiles were identified. The "No Symptoms" subgroup (60.65% of the sample) had the lowest overall scores across subscales. The "Mild Symptoms" subgroup (26.73%) was characterized by lower scores across indicators, with subscales measuring somatic symptoms being the highest within group. The "Moderate Symptoms" subgroup (10.32%) had higher scores across subscales (1 SD above the mean), with subscales measuring negative affect/loss of interest being the highest within group. Finally, the "Acute symptoms" subgroup (2.30%) was characterized by the highest overall scores (1.5-3 SD above the mean) on all indicators. After controlling for sociodemographic characteristics and health behaviors, the "Moderate Symptoms" subgroup was significantly associated with metabolic syndrome (OR = 1.595, p = 0.035) and obesity (OR = 1.555, p = 0.046). Further, there was a trend between the "Mild Symptoms" subgroup and the presence of obesity (OR = 1.345, p = 0.050). Inflammation attenuated these associations.
   Conclusions: Four depressive symptom profiles were identified among healthy mid-life individuals in the US. These profiles are differentially associated with cardio-metabolic outcomes. Future work should examine whether distinct symptom profiles may reflect differential pathways to increased risk, and whether tailored management of symptoms is needed.
C1 [Chirinos, Diana A.; Murdock, Kyle W.; LeRoy, Angie S.; Fagundes, Christopher] Rice Univ, Dept Psychol, Houston, TX 77251 USA.
   [LeRoy, Angie S.] Univ Houston, Dept Psychol, Houston, TX USA.
   [Fagundes, Christopher] Univ Texas MD Anderson Canc Ctr, Dept Symptom Res, Houston, TX 77030 USA.
   [Fagundes, Christopher] Baylor Coll Med, Dept Psychiat, Houston, TX 77030 USA.
C3 Rice University; University of Houston System; University of Houston;
   University of Texas System; UTMD Anderson Cancer Center; Baylor College
   of Medicine
RP Chirinos, DA (corresponding author), Rice Univ, Dept Psychol, Houston, TX 77251 USA.
EM dcm5@rice.edu
RI LeRoy, Angie/JZE-5550-2024
OI LeRoy, Angie/0000-0003-2143-7634
FU National Institute on Aging [P01-AG020166]; National Heart, Lung, and
   Blood Institute [1R01HL127260-01]
FX Data collection for the present study was funded by the National
   Institute on Aging (P01-AG020166). Authors of this manuscript were
   supported by the National Heart, Lung, and Blood Institute
   (1R01HL127260-01).
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NR 50
TC 24
Z9 27
U1 2
U2 21
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD AUG
PY 2017
VL 82
BP 17
EP 25
DI 10.1016/j.psyneuen.2017.04.011
PG 9
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA FA2EX
UT WOS:000405254700003
PM 28486177
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Zachariae, R
   Melchiorsen, H
   Frobert, O
   Bjerring, P
   Bagger, JP
AF Zachariae, R
   Melchiorsen, H
   Frobert, O
   Bjerring, P
   Bagger, JP
TI Experimental pain and psychologic status of patients with chest pain
   with normal coronary arteries or ischemic heart disease
SO AMERICAN HEART JOURNAL
LA English
DT Article
ID COPING STRATEGIES; SYNDROME-X; MICROVASCULAR ANGINA; QUESTIONNAIRE;
   WOMEN; PERCEPTION; DEPRESSION; SERTRALINE; THRESHOLD; STRESS
AB Background The cause of chest pain in patients with a normal coronary angiogram (NCA) remains an enigma. Also, it is unclear whether psychosocial factors play a role in the etiology of chest pain in these patients. The objective of the current study was to compare psychosocial Factors, clinical pain, and responses to experimental pain in NCA patients, patients with ischemic heart disease (IHD), and healthy control subjects.
   Methods Pain intensity, threshold, and tolerance to cold presser pain were assessed in 30 NCA patients, 30 IHD patients, and 30 healthy control subjects matched for age, sex, and sociodemographic factors. All subjects completed questionnaires measuring a number of psychosocial factors, including stress, anxiety, depression, extroversion, and neuroticism. NCA and]HD patients also completed questionnaires assessing clinical pain responses and pain-coping strategies.
   Results With the exception of a lower tolerance to cold presser pain of IHD patients (P < .05), no significant differences were found between NCA and IHD patients with respect to other clinical pain measures, psychosocial measures, pain-coping strategies, and other pain-related behaviors. Healthy control subjects differed significantly (P < .05) from both IHD and NCA patients with respect to maximum cold presser pain, depression, and state anxiety and From IHD patients with respect to intensity of cold presser pain, threshold ie cold presser pain, and perceived stress.
   Conclusions The results suggest that higher scores on various psychosocial measures in both chest pain groups are related to their pain, rather than being the cause of pain, and do not support a psychogenic explanation for chest pain in the presence of normal coronary arteries.
C1 Hammersmith Hosp, Sch Med, Imperial Coll, London, England.
   Aarhus Univ Hosp, Dept Dermatol, DK-8000 Aarhus, Denmark.
   Aarhus Univ Hosp, Dept Cardiol, DK-8000 Aarhus, Denmark.
   Aarhus Univ Hosp, Inst Psychol, DK-8000 Aarhus, Denmark.
C3 Imperial College London; Aarhus University; Aarhus University; Aarhus
   University
RP Frobert, O (corresponding author), Aarhus Univ Hosp, Skejby Sygehus, Dept Cardiol B, DK-8200 Aarhus N, Denmark.
RI Frobert, Ole/AFP-8888-2022
OI Frobert, Ole/0000-0002-5846-345X; Zachariae, Robert/0000-0001-9076-3068
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NR 34
TC 28
Z9 30
U1 0
U2 5
PU MOSBY, INC
PI ST LOUIS
PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 USA
SN 0002-8703
J9 AM HEART J
JI Am. Heart J.
PD JUL
PY 2001
VL 142
IS 1
BP 63
EP 71
DI 10.1067/mhj.2001.115794
PG 9
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Cardiovascular System & Cardiology
GA 449HF
UT WOS:000169677700011
PM 11431658
DA 2025-06-11
ER

PT J
AU Nikrad, N
   Shakarami, A
   Rahimi, Z
   Janghorbanian-Poodeh, R
   Farhangi, MA
   Hosseini, B
   Jafarzadeh, F
AF Nikrad, Negin
   Shakarami, Amir
   Rahimi, Zahra
   Janghorbanian-Poodeh, Raheleh
   Farhangi, Mahdieh Abbasalizad
   Hosseini, Babak
   Jafarzadeh, Faria
TI Dietary pro-oxidant score (POS) and cardio-metabolic panel among obese
   individuals: a cross-sectional study
SO BMC ENDOCRINE DISORDERS
LA English
DT Article
DE Dietary pro-oxidant score; Obesity; Metabolic parameters; Blood
   pressure; Lipid profile
ID POLYUNSATURATED FATTY-ACIDS; OXIDATIVE STRESS; PHYSICAL-ACTIVITY;
   LIPID-PEROXIDATION; SERUM FERRITIN; ENDOTHELIAL DYSFUNCTION;
   BLOOD-PRESSURE; IRON; ASSOCIATION; HEALTH
AB BackgroundOxidative stress is a disturbance in the natural balance between oxidative and anti-oxidative processes, which is the major effective factor in cardiovascular disorders and metabolic syndrome (MetS), due to the role of pro-oxidants in inducing oxidative stress, and as a result, the occurrence and exacerbation of components of metabolic syndrome and cardiovascular risk factors, this cross-sectional study was conducted with the aim of investigating the relationship between the status of dietary pro-oxidants score (POS) and metabolic parameters including serum lipids, glycemic markers and blood pressure among obese adults.Methods338 individuals with obesity (BMI & GE; 30 kg/m (2)), aged between 20 and 50 years were recruited in the present cross-sectional study. A validated food frequency questionnaire (FFQ) was used to determine the dietary pro-oxidant score (POS). Analysis of variance (ANOVA) with Tukey's post-hoc comparisons after adjustment for confounders and multivariable logistic regression analysis were performed to determine the association of cardiometabolic risk factors among the tertiles of POS.ResultsParticipants with higher POS had lower levels of body mass index (BMI), weight and waist circumference (WC). There were no significant associations between metabolic parameters including glycemic markers and lipid profile in one-way ANOVA and multivariate multinomial logistic regression models.ConclusionsThe findings of this study revealed that greater dietary pro-oxidant intake might be associated with lower BMI, body weight, and WC in Iranian obese individuals. Further studies with interventional or longitudinal approaches will help to better elucidate the causality of the observed associations.
C1 [Nikrad, Negin; Farhangi, Mahdieh Abbasalizad] Tabriz Univ Med Sci, Tabriz Hlth Serv Management Res Ctr, Tabriz, Iran.
   [Shakarami, Amir] Lorestan Univ Med Sci, Dept Cardiovasc Med, Khorramabad, Iran.
   [Rahimi, Zahra] Farhangian Univ, Teachers Training Ctr, Teaching Expt Sci Grp, Pardis Bahonar Fac, Esfahan, Iran.
   [Janghorbanian-Poodeh, Raheleh] Isfahan Univ Med Sci, Heart Dept Chamran Subspecial Heart Hosp, Coronary Angiog Grp, Esfahan, Iran.
   [Farhangi, Mahdieh Abbasalizad] Tabriz Univ Med Sci, Fac Nutr, Dept Community Nutr, Tabriz, Iran.
   [Hosseini, Babak] Shiraz Univ Med Sci, Laparoscopy Res Ctr, Sch Med, Dept Surg, Shiraz, Iran.
   [Jafarzadeh, Faria] North Khorasan Univ Med Sci, Sch Med, Dept Internal Med, Bojnourd, Iran.
C3 Tabriz University of Medical Science; Lorestan University of Medical
   Sciences; Isfahan University of Medical Sciences; Tabriz University of
   Medical Science; Shiraz University of Medical Science; North Khorasan
   University of Medical Sciences
RP Hosseini, B (corresponding author), Shiraz Univ Med Sci, Laparoscopy Res Ctr, Sch Med, Dept Surg, Shiraz, Iran.; Jafarzadeh, F (corresponding author), North Khorasan Univ Med Sci, Sch Med, Dept Internal Med, Bojnourd, Iran.
EM hosseinibabak633@gmail.com; fariajafarzadeh@yahoo.com
RI Shakarami, Amir/KVA-6459-2024; Farhangi, Mahdieh/AAC-6758-2019;
   jafarzadeh, faria/E-1413-2018; Rahimi, Zahra/JUU-7862-2023; Nikrad,
   Negin/JZD-3883-2024; Hosseini, Babak/AAQ-4628-2021
OI JAFARZADEH, FARIA/0009-0003-5883-098X
FU Research Undersecretary of Tabriz University of Medical Sciences [72153]
FX AcknowledgementsThe authors wish to thank all the study participants for
   the sincere collaboration. We also thank from Research Undersecretary of
   Tabriz University of Medical Sciences for their financial support (Grant
   number: 72153).
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NR 67
TC 1
Z9 1
U1 1
U2 4
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1472-6823
J9 BMC ENDOCR DISORD
JI BMC Endocr. Disord.
PD JUL 10
PY 2023
VL 23
IS 1
AR 144
DI 10.1186/s12902-023-01395-2
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA L8PQ2
UT WOS:001025832600004
PM 37430312
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Han, KM
   Shin, C
   Yoon, HK
   Ko, YH
   Kim, YK
   Han, C
AF Han, Kyu-Man
   Shin, Cheolmin
   Yoon, Ho-Kyoung
   Ko, Young-Hoon
   Kim, Yong-Ku
   Han, Changsu
TI Emotional labor and depressive mood in service and sales workers:
   Interactions with gender and job autonomy
SO PSYCHIATRY RESEARCH
LA English
DT Article
DE Emotional labor; Emotional demand; Job autonomy; Job demand-control
   model; Depression; Stress; Gender
ID NATIONALLY REPRESENTATIVE SAMPLE; EXAMINATION SURVEY KNHANES; SELF-RATED
   HEALTH; SUICIDAL IDEATION; METABOLIC SYNDROME; WAGE WORKERS; SYMPTOMS;
   KOREA; PREVALENCE; DISORDERS
AB Emotional labor is strongly correlated with negative consequences in psychological well-being and mental health status in workers. We investigated the associations of emotional labor with depressive mood and perceived usual stress level according to gender and its interactions with job autonomy in service and sales workers. The data from 2,055 service and sales workers from the Korea National Health and Nutrition Examination Surveys (KNHANES) conducted from 2007 to 2009 were analyzed. High emotional labor was associated with increased risk for depressive mood in female workers (adjusted odds ratio [aOR] = 2.19, 95%, confidence interval [CI] = 1.56-3.07). Emotional labor and job autonomy showed interactive effects on depressive mood in that high emotional labor was associated with depressive mood only in the presence of low job autonomy in male workers (aOR = 2.85, 95% CI = 1.13-7.17). A significant mediation pathway between high emotional demand and prevalence of depressive mood through higher stress level was observed in female workers. In conclusion, female workers had high vulnerability to depressive symptoms due to emotional labor, and high job autonomy can act as a buffer against the detrimental effect of emotional labor in male workers.
C1 [Han, Kyu-Man; Shin, Cheolmin; Yoon, Ho-Kyoung; Ko, Young-Hoon; Kim, Yong-Ku; Han, Changsu] Korea Univ, Korea Univ Ansan Hosp, Coll Med, Dept Psychiat, Ansan, South Korea.
C3 Korea University; Korea University Medicine (KU Medicine)
RP Han, C (corresponding author), Korea Univ, Korea Univ Ansan Hosp, Coll Med, Dept Psychiat, Ansan, South Korea.
EM hancs@korea.ac.kr
RI Kim, Yong-Ku/AAF-1680-2020; Shin, Cheolmin/AAX-7092-2020; Han,
   Changsu/H-9926-2013
OI Shin, Cheolmin/0000-0002-8232-2921; Han, Changsu/0000-0002-4021-8907;
   Han, Kyu-Man/0000-0002-1982-4216; Ko, Young-Hoon/0000-0002-5352-2158
FU Korea Health Technology R&D Project through the Korea Health Industry
   Development Institute (KHIDI) - Ministry of Health & Welfare, Republic
   of Korea [HC15C1405]
FX This research was supported by a grant from the Korea Health Technology
   R&D Project through the Korea Health Industry Development Institute
   (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea
   (HC15C1405).
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NR 49
TC 24
Z9 30
U1 1
U2 36
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0165-1781
J9 PSYCHIAT RES
JI Psychiatry Res.
PD SEP
PY 2018
VL 267
BP 490
EP 498
DI 10.1016/j.psychres.2018.06.044
PG 9
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA GV3GZ
UT WOS:000445983700072
PM 29980129
DA 2025-06-11
ER

PT J
AU Franz, R
   Maturana, MA
   Magalhaes, JA
   Moraes, RS
   Spritzer, PM
AF Franz, R.
   Maturana, M. A.
   Magalhaes, J. A.
   Moraes, R. S.
   Spritzer, P. M.
TI Central adiposity and decreased heart rate variability in postmenopause:
   a cross-sectional study
SO CLIMACTERIC
LA English
DT Article
DE MENOPAUSE; WAIST CIRCUMFERENCE; CARDIAC AUTONOMIC MODULATION;
   CARDIOVASCULAR RISK; CENTRAL OBESITY
ID CARDIOVASCULAR RISK-FACTORS; POLYCYSTIC-OVARY-SYNDROME; METABOLIC
   SYNDROME; WAIST CIRCUMFERENCE; INSULIN-RESISTANCE; ANDROGEN LEVELS;
   CARDIOMETABOLIC RISK; FAT DISTRIBUTION; WOMENS HEALTH; BODY-MASS
AB Objective To investigate the impact of waist circumference (WC) on heart rate variability in 87 apparently healthy, postmenopausal women.
   Methods In this cross-sectional study, time-and frequency-domain heart rate variability indices were determined at rest and during sympathetic stimulation with mental stress. Patients were stratified according to WC >= or < 88 cm. The mean (+/- standard deviation) age was 55 +/- 5 years. The median time since menopause was 6 (range 1-22) years. Age and time since menopause were similar.
   Results The mean body mass index was 27.12 +/- 4.49 kg/m(2). Metabolic syndrome was diagnosed in 26 (29.5%) participants. Thirty-eight participants (43.6%) had hypertension. Women with WC >= 88 cm had higher body mass index, glucose and insulin (both fasting and after a 75-g oral glucose tolerance test), HOMA, triglycerides, and free androgen index (p < 0.05). The metabolic syndrome was more frequent in women with WC > 88 cm (24.13% vs. 5.74%; p < 0.01). At rest, women with WC > 88 cm presented lower vagal modulation, expressed by a reduction in the mean of all normal RR intervals (mean RR) (p < 0.01) and root mean square of successive differences of adjacent RR intervals (rMSSD) (p < 0.05) than women with WC < 88 cm. Mental stress significantly increased sympathetic modulation in both groups, expressed by reduction in high frequency (HF), increase in low frequency (LF) and LF/F ratio, and reduction in mean RR and rMSSD.
   Conclusions Less favorable metabolic profile and lower cardiac vagal modulation with preserved sympathetic responsiveness were found in participants with WC >= 88 cm, suggesting that central adiposity may be associated with decreased heart rate variability in apparently healthy, postmenopausal women.
C1 [Franz, R.; Maturana, M. A.; Spritzer, P. M.] Hosp Clin Porto Alegre, Div Endocrinol, Gynecol Endocrinol Unit, BR-90035003 Porto Alegre, RS, Brazil.
   [Magalhaes, J. A.] Hosp Clin Porto Alegre, Div Obstet & Gynecol, BR-90035003 Porto Alegre, RS, Brazil.
   [Moraes, R. S.] Hosp Clin Porto Alegre, Div Cardiol, BR-90035003 Porto Alegre, RS, Brazil.
   [Spritzer, P. M.] Univ Fed Rio Grande do Sul, Dept Physiol, Mol Endocrinol Lab, Porto Alegre, RS, Brazil.
   [Spritzer, P. M.] Natl Inst Hormones & Womens Health CNPq, Porto Alegre, RS, Brazil.
C3 Hospital de Clinicas de Porto Alegre; Hospital de Clinicas de Porto
   Alegre; Hospital de Clinicas de Porto Alegre; Universidade Federal do
   Rio Grande do Sul
RP Spritzer, PM (corresponding author), Hosp Clin Porto Alegre, Div Endocrinol, Rua Ramiro Barcelos 2350, BR-90035003 Porto Alegre, RS, Brazil.
RI Maturana, M/G-9717-2013; Moraes, Ruy/W-5089-2019; Spritzer,
   Poli/A-3357-2019
OI Silveira Moraes, Ruy/0000-0001-6802-7128; Spritzer, Poli
   Mara/0000-0002-5204-107X
FU Conselho Nacional de Desenvolvimento Cientifico e Tecnologico [CNPq INCT
   573747/008-3]; Fundo de Apoio a Pesquisa do Hospital de Clinicas de
   Porto Alegre, Brazil [FIPE-HCPA 100317]
FX The study was supported by grants from Conselho Nacional de
   Desenvolvimento Cientifico e Tecnologico (CNPq INCT 573747/008-3) and
   Fundo de Apoio a Pesquisa do Hospital de Clinicas de Porto Alegre
   (FIPE-HCPA 100317), Brazil.
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NR 67
TC 13
Z9 13
U1 2
U2 11
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1369-7137
EI 1473-0804
J9 CLIMACTERIC
JI Climacteric
PD OCT
PY 2013
VL 16
IS 5
BP 576
EP 583
DI 10.3109/13697137.2012.745123
PG 8
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA 220JD
UT WOS:000324578200011
PM 23234242
DA 2025-06-11
ER

PT J
AU de Cossío, LF
   Fourrier, C
   Sauvant, J
   Everard, A
   Capuron, L
   Cani, PD
   Layé, S
   Castanon, N
AF de Cossio, Lourdes Fernandez
   Fourrier, Celia
   Sauvant, Julie
   Everard, Amandine
   Capuron, Lucile
   Cani, Patrice D.
   Laye, Sophie
   Castanon, Nathalie
TI Impact of prebiotics on metabolic and behavioral alterations in a mouse
   model of metabolic syndrome
SO BRAIN BEHAVIOR AND IMMUNITY
LA English
DT Article
DE Metabolic syndrome; Gut microbiota; Prebiotics; db/db mice; Hippocampus;
   Hypothalamus; Inflammation; Cytokines; Anxiety; Spatial memory
ID ANXIETY-LIKE BEHAVIOR; DEPRESSIVE-LIKE BEHAVIOR; LOW-GRADE INFLAMMATION;
   GUT-MICROBIOTA; INDOLEAMINE 2,3-DIOXYGENASE; INTESTINAL PERMEABILITY;
   INSULIN SENSITIVITY; IMMUNE-SYSTEM; OBESE MICE; BRAIN
AB Mounting evidence shows that the gut microbiota, an important player within the gut-brain communication axis, can affect metabolism, inflammation, brain function and behavior. Interestingly, gut micro biota composition is known to be altered in patients with metabolic syndrome (MetS), who also often display neuropsychiatric symptoms. The use of prebiotics, which beneficially alters the microbiota, may therefore be a promising way to potentially improve physical and mental health in MetS patients.
   This hypothesis was tested in a mouse model of MetS, namely the obese and type-2 diabetic dbldb mice, which display emotional and cognitive alterations associated with changes in gut microbiota composition and hippocampal inflammation compared to their lean db/+ littermates. We assessed the impact of chronic administration (8 weeks) of prebiotics (oligofructose) on both metabolic (body weight, food intake, glucose homeostasis) and behavioral (increased anxiety-like behavior and impaired spatial memory) alterations characterizing dbldb mice, as well as related neurobiological correlates, with particular attention to neuroinflammatory processes.
   Prebiotic administration improved excessive food intake and glycemic dysregulations (glucose tolerance and insulin resistance) in dbldb mice. This was accompanied by an increase of plasma antiinflammatory cytokine IL-10 levels and hypothalamic mRNA expression of the anorexigenic cytokine IL-18, whereas unbalanced mRNA expression of hypothalamic orexigenic (NPY) and anorexigenic (CART, POMC) peptides was unchanged. We also detected signs of improved blood-brain-barrier integrity in the hypothalamus of oligofructose-treated dbldb mice (normalized expression of tight junction proteins ZO-1 and occludin). On the contrary, prebiotic administration did not improve behavioral alterations and associated reduction of hippocampal neurogenesis displayed by db/db mice, despite normalization of increased hippocampal IL-6 mRNA expression. Of note, we found a relationship between the effect of treatment on dentate gyrus neurons and spatial memory. These findings may prove valuable for introducing novel approaches to treat some of the comorbidities associated with MetS. (C) 2016 Elsevier Inc. All rights reserved.
C1 [de Cossio, Lourdes Fernandez; Fourrier, Celia; Sauvant, Julie; Capuron, Lucile; Laye, Sophie; Castanon, Nathalie] INRA, Nutr & Integrat Neurobiol, UMR 1286, F-33076 Bordeaux, France.
   [de Cossio, Lourdes Fernandez; Fourrier, Celia; Sauvant, Julie; Capuron, Lucile; Laye, Sophie; Castanon, Nathalie] Univ Bordeaux, Nutr & Integrat Neurobiol, UMR 1286, F-33076 Bordeaux, France.
   [Everard, Amandine; Cani, Patrice D.] Catholic Univ Louvain, Louvain Drug Res Inst, WELBIO Walloon Excellence Life Sci & Biotechnol, Metab & Nutr Res Grp, B-1200 Brussels, Belgium.
C3 Universite de Bordeaux; Institut National de la Sante et de la Recherche
   Medicale (Inserm); INRAE; Universite de Bordeaux; Institut National de
   la Sante et de la Recherche Medicale (Inserm); Universite Catholique
   Louvain; WELBIO
RP Castanon, N (corresponding author), Univ Victor Segalen, Nutr & Neurobiol Integree, INRA, UMR 1286, Batiment UFR Pharm,2 Tranche,2 Etage, F-33076 Bordeaux, France.
EM nathalie.castanon@inra.fr
RI SAUVANT, Julie/AAK-3263-2021; Laye, Sophie/AAX-2501-2020; Cani, Patrice
   D./M-8055-2016
OI Capuron, Lucile/0000-0002-2060-5918; Laye, Sophie/0000-0002-3843-1012;
   Castanon, Nathalie/0000-0002-0079-0562; Fourrier,
   Celia/0000-0003-1505-1559; Cani, Patrice D./0000-0003-2040-2448;
   Everard, Amandine/0000-0001-8925-8144
FU Institut National de la Recherche Agronomique (INRA); Region Aquitaine;
   NEURASMUS Program-Erasmus Mundus Master's Scholarship; INRA (Departement
   de Nutrition Humaine); FRS-FNRS; FRFS-WELBIO [WELBIO-CR-2012S-02R];
   Funds Baillet Latour; ERC Starting Grant [336452-ENIGMO]
FX This work was supported by the Institut National de la Recherche
   Agronomique (INRA) and by the Region Aquitaine. L.F. de C. was supported
   by a NEURASMUS Program-Erasmus Mundus Master's Scholarship. C.F. was
   supported by a doctoral fellowship from the Region Aquitaine and the
   INRA (Departement de Nutrition Humaine). P.D.C is a research associate
   at FRS-FNRS (Fonds de la Recherche Scientifique), Belgium. A.E. is a
   post-doctoral researcher at FRS-FNRS, Belgium. P.D.C is the recipient of
   grants from FRS-FNRS, the FRFS-WELBIO under grant: WELBIO-CR-2012S-02R,
   the Funds Baillet Latour. P.D.C. is a recipient of an ERC Starting Grant
   2013 (Starting grant 336452-ENIGMO). The funders had no role in study
   design, data collection and analysis, decision to publish, or
   preparation of the manuscript.
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NR 100
TC 67
Z9 73
U1 4
U2 61
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0889-1591
EI 1090-2139
J9 BRAIN BEHAV IMMUN
JI Brain Behav. Immun.
PD AUG
PY 2017
VL 64
BP 33
EP 49
DI 10.1016/j.bbi.2016.12.022
PG 17
WC Immunology; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Neurosciences & Neurology; Psychiatry
GA EZ1XR
UT WOS:000404504600005
PM 28027925
DA 2025-06-11
ER

PT J
AU Shintani, S
   Nishiyama, Y
   Yamamoto, K
   Koga, Y
AF Shintani, S
   Nishiyama, Y
   Yamamoto, K
   Koga, Y
TI Different long-term course between chest pain and exercise-induced ST
   depression in syndrome X
SO JAPANESE HEART JOURNAL
LA English
DT Article
DE chest pain; exercise-induced ST depression; prognosis; syndrome X
ID NORMAL CORONARY ARTERIOGRAMS; CARDIAC SYNDROME-X; LEFT-VENTRICULAR
   FUNCTION; ANGINA-PECTORIS; FOLLOW-UP; MICROVASCULAR ANGINA;
   INSULIN-RESISTANCE; SEGMENT DEPRESSION; PLASMA ENDOTHELIN; ANGIOGRAMS
AB The aim of the present study was to assess the long-term clinical course of patients with syndrome X. focusing on different Courses between exercise-induced ST depression and chest pain. Forty-three patitheents with syndrome X were followed up for 6.4 +/- 3.8 years. They were divided into the 3 groups according to chest pain: disappeared (n = 24). improved (n = 14), or unchanged (n = 5). No patients had cardiac events and all had a favorable long-term prognosis. In patients showing disappearance of chest pain, exercise-induced ST depression and rate-pressure product (RPP) at peak exercise did not change during follow-up. However, ST depression and RPP decreased significantly in those with improved chest pain. These observations suggest that abnormal pain perception plays an important role in the development of chest pain.
C1 Kurume Univ, Med Ctr, Div Cardiol, Kurume, Fukuoka, Japan.
C3 Kurume University
RP Nishiyama, Y (corresponding author), 115-4 Waifu, Kikuchi, Kumamoto 8611331, Japan.
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NR 28
TC 3
Z9 4
U1 0
U2 1
PU JAPAN HEART JOURNAL, SECOND DEPT OF INTERNAL MED
PI TOKYO
PA TOKYO UNIV HOSPITAL, HONGO 7-3-1, BUNKYO-KU, TOKYO, 113, JAPAN
SN 0021-4868
J9 JPN HEART J
JI Jpn. Heart J.
PD JUL
PY 2003
VL 44
IS 4
BP 471
EP 479
DI 10.1536/jhj.44.471
PG 9
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 716NR
UT WOS:000185035700003
PM 12906029
OA Bronze
DA 2025-06-11
ER

PT J
AU Chrousos, GP
   Kino, T
AF Chrousos, George P.
   Kino, Tomoshige
TI Glucocorticoid action networks and complex psychiatric and/or somatic
   disorders
SO STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS
LA English
DT Article
DE chronic stress; cortisol; Cushing's syndrome;
   hypothalamic-pituitary-adrenal axis; inflammation; insulin resistance
ID FRAGMENT-LENGTH-POLYMORPHISM; PITUITARY-ADRENAL AXIS; RECEPTOR GENE;
   TRANSCRIPTIONAL ACTIVITY; N363S POLYMORPHISM; METABOLIC SYNDROME;
   STRESS; SENSITIVITY; ASSOCIATION; NEUROENDOCRINE
AB Glucocorticoids contribute fundamentally to the maintenance of basal and stress-related homeostasis in all higher organisms. These hormones influence a large percentage of the expressed human genome and their effects spare almost no organs or tissues. Glucocorticoids influence many functions of the central nervous system, such as arousal, cognition, mood and sleep, the activity and direction of intermediary metabolism, the maintenance of a normal cardiovascular tone, the activity and quality of the immune and inflammatory reaction, including the manifestations of the sickness syndrome, as well as growth and reproduction. The numerous actions of glucocorticoids are mediated by a set of at least 16 glucocorticoid receptor (GR) isoforms forming homo- or hetero-dimers. The GRs consist of multifunctional domain proteins operating as ligand-dependent transcription factors that interact with many other cell signaling systems. The presence of multiple GR monomers and dimers expressed in a cell-specific fashion at different quantities with quantitatively and qualitatively different transcriptional activities suggests that the glucocorticoid signaling system is highly stochastic. Based on ample evidence, we present our conception that glucocorticoids are heavily involved in human pathophysiology and influence life expectancy. Common psychiatric and/or somatic complex disorders, such as anxiety, depression, insomnia, chronic pain and fatigue syndromes, obesity, the metabolic syndrome, essential hypertension, diabetes type 2, atherosclerosis with its cardiovascular sequelae, and osteoporosis, as well as autoimmune inflammatory and allergic disorders, all appear to have a glucocorticoid component.
C1 NICHHD, Clin Res Ctr, NIH, Pediat Endocrinol Sect,Reprod Biol & Med Branch, Bethesda, MD 20892 USA.
   Univ Athens, Sch Med, Dept Pediat 1, GR-11527 Athens, Greece.
C3 National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver
   National Institute of Child Health & Human Development (NICHD); Athens
   Medical School; National & Kapodistrian University of Athens
RP Chrousos, GP (corresponding author), NICHHD, Clin Res Ctr, NIH, Pediat Endocrinol Sect,Reprod Biol & Med Branch, Bldg 10,Room 1-3140,10 Ctr Dr MSC 1109, Bethesda, MD 20892 USA.
EM chrousog@mail.nih.gov
RI Chrousos, George/G-8702-2011
FU Intramural NIH HHS Funding Source: Medline
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NR 47
TC 221
Z9 260
U1 2
U2 27
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1025-3890
EI 1607-8888
J9 STRESS
JI Stress
PY 2007
VL 10
IS 2
BP 213
EP 219
DI 10.1080/10253890701292119
PG 7
WC Behavioral Sciences; Endocrinology & Metabolism; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Behavioral Sciences; Endocrinology & Metabolism; Neurosciences &
   Neurology
GA 176DO
UT WOS:000247064300013
PM 17514590
OA Bronze
DA 2025-06-11
ER

PT J
AU Podfigurna-Stopa, A
   Luisi, S
   Regini, C
   Katulski, K
   Centini, G
   Meczekalski, B
   Petraglia, F
AF Podfigurna-Stopa, Agnieszka
   Luisi, Stefano
   Regini, Cristina
   Katulski, Krzysztof
   Centini, Gabriele
   Meczekalski, Blazej
   Petraglia, Felice
TI Mood disorders and quality of life in polycystic ovary syndrome
SO GYNECOLOGICAL ENDOCRINOLOGY
LA English
DT Review
DE Acne; infertility; mood disorders; obesity; polycystic ovary syndrome;
   quality of life; stress
ID DEPRESSION SYMPTOMS; METABOLIC SYNDROME; WOMEN; ANXIETY; HEALTH; RISK;
   SATISFACTION; DYSFUNCTION; INFERTILITY; PREVALENCE
AB Polycystic ovary syndrome (PCOS) affects 5-10% of the population of women. The exact etiology of PCOS remains unclear, but it is believed to result from complex interactions between genetic, behavioral and environmental factors. The spectrum of its symptoms such as hirsutism, skin problems, obesity and finally infertility has a huge negative impact on the individuals' psychological and interpersonal functioning. PCOS symptoms can lead to significant deterioration in quality of life and be highly stressful negatively affecting psychological well-being and sexuality. Fear symptoms like palpitation, being out of breath and tension might be caused by many somatic diseases. Moreover, detection and continuous thinking about illness can lead to significant negative impact on individual functioning in society. PCOS may be a factor potentially favoring the occurrence of mood disorders and depression. Biological, social and psychological consequences of PCOS among women of reproductive age are opening a new perspective on management of women's health in these patients.
C1 [Podfigurna-Stopa, Agnieszka; Katulski, Krzysztof; Centini, Gabriele; Meczekalski, Blazej] Poznan Univ Med Sci, Dept Gynecol Endocrinol, Poznan, Poland.
   [Luisi, Stefano; Regini, Cristina; Petraglia, Felice] Univ Siena, Obstet & Gynecol, Dept Mol & Dev Med, I-53100 Siena, Italy.
C3 Poznan University of Medical Sciences; University of Siena
RP Luisi, S (corresponding author), Univ Siena, Dept Mol & Dev Med, Policlin Le Scotte, Viale Bracci, I-53100 Siena, Italy.
EM stefano.luisi@unisi.it
RI centini, gabriele/AAN-9888-2020; Luisi, Stefano/HNP-5305-2023;
   PETRAGLIA, Felice/D-4373-2019; PETRAGLIA, Felice/K-6535-2016
OI centini, gabriele/0000-0002-6113-7401; PETRAGLIA,
   Felice/0000-0002-8851-625X; LUISI, Stefano/0000-0002-3602-0666
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NR 51
TC 41
Z9 43
U1 0
U2 22
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0951-3590
EI 1473-0766
J9 GYNECOL ENDOCRINOL
JI Gynecol. Endocrinol.
PD JUN
PY 2015
VL 31
IS 6
BP 431
EP 434
DI 10.3109/09513590.2015.1009437
PG 4
WC Endocrinology & Metabolism; Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Obstetrics & Gynecology
GA CP4YM
UT WOS:000359888500003
PM 26204044
DA 2025-06-11
ER

PT J
AU Ahola, AJ
   Forsblom, C
   Groop, PH
AF Ahola, Aila J.
   Forsblom, Carol
   Groop, Per-Henrik
CA FinnDiane Study Grp
TI Association between depressive symptoms and dietary intake in patients
   with type 1 diabetes
SO DIABETES RESEARCH AND CLINICAL PRACTICE
LA English
DT Article
DE Depressive symptoms; Dietary intake; Type 1 diabetes
ID MACRONUTRIENT INTAKE; METABOLIC SYNDROME; GUT MICROBIOTA; MENTAL-HEALTH;
   FATTY-ACID; NUTRITION; PATTERNS; INFLAMMATION; ANXIETY; RISK
AB Aims: Depressive mood negatively affects self-care practices, and thereby increases the risk of long-term complications. Not much is known about the association between depressive symptoms and dietary intake in patients with type 1 diabetes, a population with high risk of cardiovascular disease.
   Methods: Subjects (n = 976, 41% men, age 48 +/- 14 years) were participants in the Finnish Diabetic Nephropathy Study. Depressive symptomatology was assessed with the Beck Depression Inventory (BDI). Dietary patterns were derived from food frequency questionnaire-entries by exploratory factor analysis. Energy and macronutrient intakes were calculated from food records. In the same record, participants also reported the results of their daily blood glucose monitoring. Associations between BDI score and selfcare variables were analysed using generalized linear regression. For macronutrients, a substitution model was applied.
   Results: TWo dietary patterns ("Fish and vegetables", and "Traditional") negatively associated with the BDI score. Instead, an increase in the "Sweet" pattern score was positively associated with depressive symptomatology. Of the macronutrients, favouring protein over carbohydrates or fats associated with lower depression scores. Higher blood glucose selfmonitoring frequency and higher variability of the measurements were positively associated with the BDI score. However, no association was observed between depressive symptoms and the mean of the blood glucose measurements.
   Conclusions: Depressive symptoms are reflected in the dietary intake and the selfmonitoring of blood glucose, in type 1 diabetes. Whether depression, via compromised self-care practices, negatively affect long-term outcomes in this patient group has to be the subject of future studies. (C) 2018 Elsevier B.V. All rights reserved.
C1 [Ahola, Aila J.; Forsblom, Carol; Groop, Per-Henrik] Folkhalsan Res Ctr, Folkhalsan Inst Genet, Helsinki, Finland.
   [Ahola, Aila J.; Forsblom, Carol; Groop, Per-Henrik] Univ Helsinki, Abdominal Ctr Nephrol, Helsinki, Finland.
   [Ahola, Aila J.; Forsblom, Carol; Groop, Per-Henrik] Helsinki Univ Cent Hosp, Helsinki, Finland.
   [Ahola, Aila J.; Forsblom, Carol; Groop, Per-Henrik] Univ Helsinki, Res Programs Unit, Diabet & Obes, Helsinki, Finland.
   [Groop, Per-Henrik] Monash Univ, Cent Clin Sch, Dept Diabet, Melbourne, Vic, Australia.
C3 Folkhalsan Research Center; University of Helsinki; University of
   Helsinki; Helsinki University Central Hospital; University of Helsinki;
   Monash University
RP Groop, PH (corresponding author), Univ Helsinki, Folkhalsan Res Ctr, Biomed Helsinki C318b,POB 63, FI-00014 Helsinki, Finland.
EM per-henrik.groop@helsinki.fi
OI Groop, Per-Henrik/0000-0003-4055-6954; Ahola, Aila/0000-0001-5200-4597
FU Academy of Finland; Novo Nordisk Foundation; Signe and Ane Gyllenberg
   Foundation; Folkhalsan Research Foundation; Wilhelm and Else Stockmann
   Foundation; Liv och Halsa Foundation; Helsinki University Central
   Hospital Research Funds (EVO); Paivikki ja Sakari Sohlbergin Saatio;
   Diabetes Wellness Finland
FX This study was supported by grants from Academy of Finland, Novo Nordisk
   Foundation, Signe and Ane Gyllenberg Foundation, Folkhalsan Research
   Foundation, Wilhelm and Else Stockmann Foundation, Liv och Halsa
   Foundation, the Helsinki University Central Hospital Research Funds
   (EVO), Paivikki ja Sakari Sohlbergin Saatio, and Diabetes Wellness
   Finland. Funding agencies did not contribute to the study design,
   conduct of the study, data analysis, interpretation of findings, writing
   of the manuscript, or in the decision to submit the manuscript for
   publication. The skilled technical assistance of Anna Sandelin, Mira
   Korolainen, Jaana Tuomikangas, and Satu Kinnunen is gratefully
   acknowledged. The authors also acknowledge all the physicians and nurses
   at each centre participating in the collection of patients (online
   appendix).
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NR 44
TC 13
Z9 16
U1 0
U2 16
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0168-8227
EI 1872-8227
J9 DIABETES RES CLIN PR
JI Diabetes Res. Clin. Pract.
PD MAY
PY 2018
VL 139
BP 91
EP 99
DI 10.1016/j.diabres.2018.02.018
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism
GA GG7FL
UT WOS:000432863800010
PM 29475022
DA 2025-06-11
ER

PT J
AU Wiltink, J
   Beutel, ME
   Till, Y
   Ojeda, FM
   Wild, PS
   Münzel, T
   Blankenberg, S
   Michal, M
AF Wiltink, Joerg
   Beutel, Manfred E.
   Till, Yvonne
   Ojeda, Francisco M.
   Wild, Philipp S.
   Muenzel, Thomas
   Blankenberg, Stefan
   Michal, Matthias
TI Prevalence of distress, comorbid conditions and well being in the
   general population
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Anxiety; Community; Depression; Somatic comorbidity; Type D; Well being
ID CORONARY-HEART-DISEASE; PATIENT HEALTH QUESTIONNAIRE; MENTAL-DISORDERS;
   D PERSONALITY; MAJOR DEPRESSION; CARDIAC EVENTS; PANIC DISORDER;
   PSYCHIATRIC-DISORDERS; METABOLIC SYNDROME; ANXIETY DISORDER
AB Background: The purposes of this paper are to determine the prevalence of distress in the community, to identify its determinants and to assess its relationship to somatic conditions and subjective well being.
   Methods: Distress and associated factors were investigated in a random sample of 5000 participants (35-74 years) of a community-based, prospective, observational cohort study in western Mid-Germany ("Gutenberg Heart Study") between 04/2007 and 10/2008. The sample was stratified 1:1 for gender and residence and in equal strata for decades of age. Data were assessed by self-report instruments, interviews and medical examination.
   Results: We found a prevalence rate for depression of 7.2% (6.5-8.0%), social anxiety 7.0% (6.3-7.7%), panic 4.6% (4.0-5.2%), generalized anxiety 3.4% (2.9-3.9%), and Type D personality 22.1% (21.0-23.2%). Mental conditions declined by age. Depression was related to diabetes (OR = 1.99, 95% Cl = 1.26-3.15), dyslipidemia (OR = 1.35, 95% Cl = 1.02-1.79), coronary heart disease (CHD; OR = 1.88, 95% Cl = 1.04-3.39), and the history of stroke (OR = 2.43, 95% Cl = 1.02-5.76). Panic was related to the history of myocardial infarction (OR = 2.46, 95% CI = 1.15-5.25), and generalized anxiety to obesity (OR = 1.65, 95% CI = 1.11-2.44). Mental distress was unrelated to hypertension, atrial fibrillation and cancer. In ordinal logistic regression subjective physical and mental well being were associated with anxiety, depression and Type D personality.
   Conclusions: While mental conditions' are highly prevalent, especially depression is associated with several somatic conditions. Mental and physical well being are strongly related to mental conditions. Future work should take into account comorbid conditions when identifying the impact of depression on CHD. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Wiltink, Joerg; Beutel, Manfred E.; Till, Yvonne; Michal, Matthias] Johannes Gutenberg Univ Mainz, Clin Psychosomat Med & Psychotherapy, Univ Med Ctr, D-55131 Mainz, Germany.
   [Till, Yvonne; Ojeda, Francisco M.; Wild, Philipp S.; Muenzel, Thomas; Blankenberg, Stefan] Johannes Gutenberg Univ Mainz, Clin Cardiol, Univ Med Ctr, D-55131 Mainz, Germany.
C3 Johannes Gutenberg University of Mainz; Johannes Gutenberg University of
   Mainz
RP Wiltink, J (corresponding author), Johannes Gutenberg Univ Mainz, Clin Psychosomat Med & Psychotherapy, Univ Med Ctr, Untere Zahlbacher Str 8, D-55131 Mainz, Germany.
EM joerg.wiltink@unimedizin-mainz.de
RI Blankenberg, Stefan/JEZ-7394-2023; Wild, Philipp/M-2106-2019; Muenzel,
   Thomas/A-2912-2014
OI Muenzel, Thomas/0000-0001-5503-4150; Wild, Philipp/0000-0003-4413-9752
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NR 61
TC 75
Z9 81
U1 0
U2 19
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD MAY
PY 2011
VL 130
IS 3
BP 429
EP 437
DI 10.1016/j.jad.2010.10.041
PG 9
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA 771WT
UT WOS:000291192100009
PM 21106250
DA 2025-06-11
ER

PT J
AU Bilu, C
   Frolinger-Ashkenazi, T
   Einat, H
   Zimmet, P
   Bishko, Y
   Halperin, D
   Kronfeld-Schor, N
AF Bilu, Carmel
   Frolinger-Ashkenazi, Tal
   Einat, Haim
   Zimmet, Paul
   Bishko, Yulia
   Halperin, Dania
   Kronfeld-Schor, Noga
TI Effects of photoperiod and diet on BDNF daily rhythms in diurnal sand
   rats
SO BEHAVIOURAL BRAIN RESEARCH
LA English
DT Article
DE Sand rats; Depression; Diabetes; BDNF; Circadian rhythms
ID NEUROTROPHIC FACTOR BDNF; ANXIETY-LIKE BEHAVIORS; DEPRESSION-LIKE
   BEHAVIORS; CIRCADIAN VARIATIONS; METABOLIC SYNDROME; SHORT DAYLIGHT;
   PHASE-SHIFTS; BRAIN; LIGHT; RODENTS
AB Brain-derived neurotrophic factor (BDNF), its receptors and epigenetic modulators, are implicated in the pathophysiology of affective disorders, T2DM and the circadian system function. We used diurnal sand rats, which develop type 2 diabetes (T2DM), anxiety and depressive-like behavior under laboratory conditions. The development of these disorders is accelerated when animals are maintained under short photoperiod (5:19L:D, SP) compared to neutral photoperiod (12:12L:D, NP). We compared rhythms in plasma BDNF as well as BDNF and PER2 expression in the frontal cortex and suprachiasmatic nucleus (SCN) of sand rats acclimated to SP and NP. Acclimation to SP resulted in higher insulin levels, significantly higher glucose levels in the glucose tolerance test, and significantly higher anxiety-and depression-like behaviors compared with animals acclimated to NP. NP Animals exhibited a significant daily rhythm in plasma BDNF levels with higher levels during the night, and in BDNF expression levels in the frontal cortex and SCN. No significant BDNF rhythm was found in the plasma, frontal cortex or SCN of SP acclimated animals. We propose that in sand rats, BDNF may, at least in part, mediate the effects of circadian disruption on the development of anxiety and depressive-like behavior and T2DM.
C1 [Bilu, Carmel; Frolinger-Ashkenazi, Tal; Bishko, Yulia; Halperin, Dania; Kronfeld-Schor, Noga] Tel Aviv Univ, Sch Zool, IL-69978 Ramat Aviv, Israel.
   [Einat, Haim] Tel Aviv Yaffo Acad Coll, Sch Behav Sci, Tel Aviv, Israel.
   [Zimmet, Paul] Monash Univ, Dept Diabet, Melbourne, Vic, Australia.
C3 Tel Aviv University; Monash University
RP Bilu, C (corresponding author), Tel Aviv Univ, Sch Zool, IL-69978 Ramat Aviv, Israel.
EM Carmel.bilu@gmail.com
RI Zimmet, Paul/H-7635-2013; Kronfeld-Schor, Noga/AAU-3792-2020
OI Kronfeld-Schor, Noga/0000-0002-5224-3341
FU Israel Science Foundation, Israel [866/17]
FX This research was supported by the Israel Science Foundation, Israel, to
   NKS (grant No. 866/17) .
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NR 87
TC 7
Z9 7
U1 0
U2 8
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0166-4328
EI 1872-7549
J9 BEHAV BRAIN RES
JI Behav. Brain Res.
PD FEB 10
PY 2022
VL 418
AR 113666
DI 10.1016/j.bbr.2021.113666
EA NOV 2021
PG 8
WC Behavioral Sciences; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Behavioral Sciences; Neurosciences & Neurology
GA XK8IY
UT WOS:000727703300001
PM 34808195
DA 2025-06-11
ER

PT J
AU Hu, MX
   Lamers, F
   Penninx, BWJH
   de Geus, EJC
AF Hu, Mandy X.
   Lamers, Femke
   Penninx, Brenda W. J. H.
   de Geus, Eco J. C.
TI Temporal stability and drivers of change in cardiac autonomic nervous
   system activity
SO AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL
LA English
DT Article
DE Autonomic nervous system; Temporal stability; Longitudinal; Lifestyle;
   Antidepressants; Cardiac medication
ID HEART-RATE-VARIABILITY; PREEJECTION PERIOD; INDIVIDUAL-DIFFERENCES;
   CARDIOVASCULAR RISK; METABOLIC SYNDROME; PHYSICAL-ACTIVITY;
   BLOOD-PRESSURE; STRESS; DEPRESSION; REACTIVITY
AB Objectives: This study determined temporal stability of ambulatory measured cardiac autonomic activity for different time periods and investigated potential drivers of changes in this activity.
   Methods: Data was drawn from baseline (n = 2379), 2-year (n = 2245), and 6-year (n = 1876) follow-up from the Netherlands Study of Depression and Anxiety. Cardiac autonomic activity was measured with heart rate (HR), respiratory sinus arrhythmia (RSA) and pre-ejection period (PEP). Autonomic temporal stability was determined across 2, 4, and 6 year intervals. We subsequently examined the association between sociodemographics, lifestyle, mental health, cardiometabolic health, and the use of antidepressant and cardiac medication with change in cardiac autonomic activity.
   Results: Over 2 years, stability was good for HR (ICC = 0.703), excellent for RSA (ICC = 0.792) and moderate for PEP (ICC = 0.576). Stability decreased for a 4- (HR ICC = 0.688, RSA ICC = 0.652 and PEP ICC = 0.387) and 6-year interval (HR ICC = 0.633, RSA ICC = 0.654 and PEP ICC = 0.355). The most important determinants for increase in HR were (increase in) smoking, increase in body mass index (BMI) and (starting) the use of antidepressants. Beta-blocking/antiarrhythmic drug use led to a decrease in HR. Decrease in RSA was associated with age, smoking and (starting) antidepressant use. Decrease in PEP was associated with age and (increase in) BMI.
   Conclusions: Cardiac autonomic measures were rather stable over 2 years, but stability decreased with increasing time span. Determinants contributing to cardiac autonomic deterioration were older age, (increase in) smoking and BMI, and (starting) the use of antidepressants. (Starting) the use of cardiac medication improved autonomic function.
C1 [Hu, Mandy X.; Lamers, Femke; Penninx, Brenda W. J. H.] Vrije Univ Amsterdam, Med Ctr, Amsterdam Publ Hlth Res Inst, Dept Mental Hlth, Amsterdam, Netherlands.
   [de Geus, Eco J. C.] Vrije Univ Amsterdam, Dept Biol Psychol, Amsterdam, Netherlands.
C3 Vrije Universiteit Amsterdam; Vrije Universiteit Amsterdam
RP Hu, MX (corresponding author), AJ Ernststr 1187, NL-1081 HL Amsterdam, Netherlands.
EM m.hu@ggzingeest.nl
RI Lamers, Femke/G-5161-2012; Penninx, Brenda/S-7627-2017; de Geus,
   Eco/M-9318-2015
OI Hu, Mandy Xian/0000-0002-4496-8772; Lamers, Femke/0000-0003-4344-5766;
   de Geus, Eco/0000-0001-6022-2666
FU Geestkracht program of the Netherlands Organisation for Health Research
   and Development [ZonMw] [10-000-1002]; FP7-Marie Curie grant
   [PCIG12-GA-2012-334065]
FX This work was supported by the Geestkracht program of the Netherlands
   Organisation for Health Research and Development [ZonMw, grant number
   10-000-1002] and the FP7-Marie Curie grant [PCIG12-GA-2012-334065 to
   F.L.].
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NR 51
TC 7
Z9 8
U1 1
U2 7
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1566-0702
EI 1872-7484
J9 AUTON NEUROSCI-BASIC
JI Auton. Neurosci-Basic Clin.
PD DEC
PY 2017
VL 208
BP 117
EP 125
DI 10.1016/j.autneu.2017.07.005
PG 9
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology
GA FU1XK
UT WOS:000423642600015
PM 28774803
OA Green Published
DA 2025-06-11
ER

PT J
AU de Kluiver, H
   Jansen, R
   Penninx, BWJH
   Giltay, EJ
   Schoevers, RA
   Milaneschi, Y
AF de Kluiver, Hilde
   Jansen, Rick
   Penninx, Brenda W. J. H.
   Giltay, Erik J. J.
   Schoevers, Robert A. A.
   Milaneschi, Yuri
TI Metabolomics signatures of depression: the role of symptom profiles
SO TRANSLATIONAL PSYCHIATRY
LA English
DT Article
ID CHAIN AMINO-ACIDS; ATYPICAL FEATURES; BRANCHED-CHAIN;
   CARDIOVASCULAR-DISEASE; MAJOR DEPRESSION; OBESITY; ASSOCIATION;
   RESISTANCE; INVENTORY; ANXIETY
AB Depression shows a metabolomic signature overlapping with that of cardiometabolic conditions. Whether this signature is linked to specific depression profiles remains undetermined. Previous research suggested that metabolic alterations cluster more consistently with depressive symptoms of the atypical spectrum related to energy alterations, such as hyperphagia, weight gain, hypersomnia, fatigue and leaden paralysis. We characterized the metabolomic signature of an "atypical/energy-related" symptom (AES) profile and evaluated its specificity and consistency. Fifty-one metabolites measured using the Nightingale platform in 2876 participants from the Netherlands Study of Depression and Anxiety were analyzed. An 'AES profile' score was based on five items of the Inventory of Depressive Symptomatology (IDS) questionnaire. The AES profile was significantly associated with 31 metabolites including higher glycoprotein acetyls (beta = 0.13, p = 1.35*10(-12)), isoleucine (beta = 0.13, p = 1.45*10(-10)), very-low-density lipoproteins cholesterol (beta = 0.11, p = 6.19*10(-9)) and saturated fatty acid levels (beta = 0.09, p = 3.68*10(-10)), and lower high-density lipoproteins cholesterol (beta = -0.07, p = 1.14*10(-4)). The metabolites were not significantly associated with a summary score of all other IDS items not included in the AES profile. Twenty-five AES-metabolites associations were internally replicated using data from the same subjects (N = 2015) collected at 6-year follow-up. We identified a specific metabolomic signature-commonly linked to cardiometabolic disorders-associated with a depression profile characterized by atypical, energy-related symptoms. The specific clustering of a metabolomic signature with a clinical profile identifies a more homogenous subgroup of depressed patients at higher cardiometabolic risk, and may represent a valuable target for interventions aiming at reducing depression's detrimental impact on health.
C1 [de Kluiver, Hilde; Jansen, Rick; Penninx, Brenda W. J. H.; Milaneschi, Yuri] Vrije Univ Amsterdam, Dept Psychiat, Amsterdam UMC, Amsterdam, Netherlands.
   [de Kluiver, Hilde; Jansen, Rick; Penninx, Brenda W. J. H.; Milaneschi, Yuri] Amsterdam Publ Hlth, Mental Hlth program, Amsterdam, Netherlands.
   [Jansen, Rick; Penninx, Brenda W. J. H.; Milaneschi, Yuri] Amsterdam Neurosci, Mood Anxiety Psychosis Sleep & Stress program, Amsterdam, Netherlands.
   [Giltay, Erik J. J.] Leiden Univ, Dept Psychiat, Med Ctr, Leiden, Netherlands.
   [Schoevers, Robert A. A.] Univ Groningen, Univ Med Ctr Groningen, Dept Psychiat, Groningen, Netherlands.
   [Schoevers, Robert A. A.] Res Sch Behav & Cognit Neurosci BCN, Groningen, Netherlands.
C3 Vrije Universiteit Amsterdam; University of Amsterdam; Vrije
   Universiteit Amsterdam; Leiden University - Excl LUMC; Leiden
   University; Leiden University Medical Center (LUMC); University of
   Groningen
RP Milaneschi, Y (corresponding author), Vrije Univ Amsterdam, Dept Psychiat, Amsterdam UMC, Amsterdam, Netherlands.; Milaneschi, Y (corresponding author), Amsterdam Publ Hlth, Mental Hlth program, Amsterdam, Netherlands.; Milaneschi, Y (corresponding author), Amsterdam Neurosci, Mood Anxiety Psychosis Sleep & Stress program, Amsterdam, Netherlands.
EM y.milaneschi@amsterdamumc.nl
RI Giltay, Erik/AAL-9948-2021; Jansen, Ritsert/C-1160-2013; Penninx,
   Brenda/S-7627-2017
OI , Hilde/0000-0003-4835-189X; Schoevers, Robert A/0000-0003-0760-9866;
   Milaneschi, Yuri/0000-0002-3697-6617; Giltay, Erik
   J./0000-0001-8874-2292
FU ZonMw: The Netherlands Organization for Health Research and Development
   [636310017]; Netherlands Organisation for Health Research and
   Development (ZonMw) [10-000-1002]; BBMRI-NL; Dutch government (NWO)
   [184033111]; European Union [848146]
FX Funding for this work was provided by ZonMw: The Netherlands
   Organization for Health Research and Development (project number:
   636310017, research program GGZ). The infrastructure for the NESDA study
   (http://www.nesda.nl) is funded through the Geestkracht program of the
   Netherlands Organisation for Health Research and Development (ZonMw,
   grant number 10-000-1002) and financial contributions by participating
   universities and mental health care organizations (VU University Medical
   Center, GGZ inGeest, Leiden University Medical Center, Leiden
   University, GGZ Rivierduinen, University Medical Center Groningen,
   University of Groningen, Lentis, GGZ Friesland, GGZ Drenthe, Rob Giel
   Onderzoekscentrum). Metabolomics assessment was financially supported by
   BBMRI-NL, a Research Infrastructure financed by the Dutch government
   (NWO), nr. 184033111. This project is partially supported by funding
   from the European Union's Horizon 2020 research and innovation programme
   under grant agreement No 848146.
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NR 53
TC 14
Z9 14
U1 1
U2 5
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 2158-3188
J9 TRANSL PSYCHIAT
JI Transl. Psychiatr.
PD JUN 10
PY 2023
VL 13
IS 1
AR 198
DI 10.1038/s41398-023-02484-5
PG 10
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychiatry
GA I6AO2
UT WOS:001003591400001
PM 37301859
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Fuentes, E
   Venegas, B
   Munoz-Arenas, G
   Moran, C
   Flores, G
   Trevin, S
   Diaz, A
   Guevara, J
AF Fuentes, Estefania
   Venegas, Berenice
   Munoz-Arenas, Guadalupe
   Moran, Carolina
   Flores, Gonzalo
   Trevin, Samuel
   Diaz, Alfonso
   Guevara, Jorge
TI High-carbohydrate and fat diet consumption causes metabolic
   deterioration, neuronal damage, and loss of recognition memory in rats
SO JOURNAL OF CHEMICAL NEUROANATOMY
LA English
DT Article
DE Hypercaloric diets; Neural damage; Oxidative stress; Inflammaging;
   Neurodegeneration; Metabolism dysfunction
ID INSULIN-RESISTANCE; INDUCED NEUROTOXICITY; MOLECULAR-MECHANISMS;
   DENDRITIC MORPHOLOGY; OXIDATIVE STRESS; TEMPORAL CORTEX; IMPAIRMENT;
   OBESITY; CHOLESTEROL; INJECTION
AB The number of people diagnosed with metabolic syndrome (MetS) has increased dramatically to reach alarming proportions worldwide. The origin of MetS derives from bad eating habits and sedentary lifestyle. Most people consume foods high in carbohydrates and saturated fat. In recent years, it has been reported that alterations in insulin at the brain level could have an impact on the appearance of neurodegenerative diseases such as Alz-heimer's disease, Parkinson's disease, dementia, depression, and other types of disorders that compromise brain function. These alterations have been associated with damage to the structure and function of neurons located in the reptilian and limbic systems, a decrease in dendritic arborization and an exacerbated inflammatory state that impaired learning and memory and increased in the state of stress and anxiety. Although the molecular mech-anisms induced by MetS to cause neurodegeneration are not fully understood. The aim of this study is to know the effect of the intake of hypercaloric diets on the structure and function of neurons located in the frontal cortex, hypothalamus and hippocampus and its impact on behavior in rats with metabolic syndrome. In conclusion, the present study illustrated that chronic exposure to hypercaloric diets, with a high content of sugars and saturated fatty acids, induces a proinflammatory state and exacerbates oxidative stress in brain regions such as the hy-pothalamus, hippocampus, and frontal cortex, leading to dysfunction. metabolism, neuronal damage, and recognition memory loss.
C1 [Fuentes, Estefania; Munoz-Arenas, Guadalupe; Trevin, Samuel; Diaz, Alfonso] Benemerita Autonomous Univ Puebla, Fac Chem Sci, Pue, Puebla, Mexico.
   [Venegas, Berenice] Benemerita Autonomous Univ Puebla, Biol Sci Fac, Puebla, Mexico.
   [Moran, Carolina] Benemerita Autonomous Univ Puebla, Inst Sci, Puebla, Mexico.
   [Flores, Gonzalo] Benemerita Autonomous Univ Puebla, Inst Physiol, Puebla, Mexico.
   [Guevara, Jorge] Univ Nacl Autonoma Mexico, Fac Med, Dept Biochem, Mexico City, Mexico.
   [Guevara, Jorge] Natl Autonomous Univ Mexico UNAM, Fac Med, Dept Biochem, D Bldg,Copilco, Mexico City 04510, Mexico.
C3 Benemerita Universidad Autonoma de Puebla; Benemerita Universidad
   Autonoma de Puebla; Benemerita Universidad Autonoma de Puebla;
   Universidad Nacional Autonoma de Mexico
RP Guevara, J (corresponding author), Natl Autonomous Univ Mexico UNAM, Fac Med, Dept Biochem, D Bldg,Copilco, Mexico City 04510, Mexico.
EM jorge.guevara@comunidad.unam.mx
RI Venegas, Berenice/AAG-4048-2021; MORÁN, CAROLINA/AAF-4007-2019; Flores,
   Gonzalo/B-1807-2014
OI Flores, Gonzalo/0000-0002-4100-2104; Diaz, Alfonso/0000-0003-4092-6636;
   VENEGAS MENESES, BERENICE/0000-0001-9009-655X; Vazquez Roque,
   Ruben/0000-0002-2712-5714
FU National Council of Science and Technology (CONACYT) [916176]; VIEP-BUAP
   grant [TEMS-NAT22-G]; PAPIIT-UNAM [DIFA-NAT22-I];  [IN214117]
FX Estefania Fuentes thanks the National Council of Science and Technology
   (CONACYT) for the scholarship awarded (916176), as well as the Graduate
   Program in Chemical Sciences-BUAP for allowing her to pursue her PhD
   studies. Funding for this study was provided by grants from VIEP-BUAP
   grant (No. DIFA-NAT22-I) to DA and TS, (No. TEMS-NAT22-G) to TS and
   PAPIIT-UNAM (IN214117) to JG. None of the funding institutions had any
   further role in the study design, the collection of data, analyses, and
   interpretation of data, writing of the report or in the decision to
   submit the paper for publication and interpretation of data, writing of
   the report or the decision to submit the paper for publication.
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TC 15
Z9 15
U1 2
U2 10
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0891-0618
EI 1873-6300
J9 J CHEM NEUROANAT
JI J. Chem. Neuroanat.
PD APR
PY 2023
VL 129
AR 102237
DI 10.1016/j.jchemneu.2023.102237
EA FEB 2023
PG 13
WC Biochemistry & Molecular Biology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Neurosciences & Neurology
GA 8V6ZX
UT WOS:000930779700001
PM 36736441
DA 2025-06-11
ER

PT J
AU Chakraborty, S
   Bogadi, S
   Pamu, D
   Karri, VVSR
   Booker, A
   Rolfe, V
   Mohankumar, S
AF Chakraborty, Sanjib
   Bogadi, Subhasri
   Pamu, Divya
   Karri, Veera Venkata Satyanarayana Reddy
   Booker, Anthony
   Rolfe, Vivian
   Mohankumar, Suresh
TI Role of herbs at the crossroads of metabolic syndrome and mental illness
SO INDIAN JOURNAL OF BIOCHEMISTRY & BIOPHYSICS
LA English
DT Article
DE Herbs; Mental illness; Metabolic disorders; Mets
ID BODY-MASS INDEX; CARDIOVASCULAR-DISEASE; WAIST CIRCUMFERENCE;
   RISK-FACTORS; HEALTH; DEPRESSION; ASSOCIATION; PREVALENCE; ADULTS
AB The potential use of herbs in treating and managing comorbidities is emerging. Mental illnesses (MIs) are a widespread cause of distress and dysfunction and substantially impact one's quality of life. While the precise reason for the onset of mental illness is elusive, several chronic health complications, including metabolic syndrome (MetS), affect an individual's well-being. Thus, it is beneficial to identify the intercepts and explore the role of herbs in combating MetS-associated MIs or vice versa. This study explores the relationship between Mets and mental illness and assesses which herbs may have properties that benefit both conditions. The research design and selection process were done among the mental disorder individuals with two sets of keywords and expanded controlled vocabulary phrases, nine databases for systematic literature searches, critical assessment of the papers obtained, and meta-analysis. Our findings suggest that the excess levels of inflammatory cytokines such as C-reactive protein, interleukin, and leptin resistance in MetS strongly correlate with MIs such as depression. The resulting cross-sectional pooled odds ratio was 1.75 (95% CI 1.60-1.92), indicating a strong relationship between Mets and MIs. This study provides an essential theoretical foundation for therapeutic options and prospective intervention methods for comorbid Mets and mental illness. Some herbs have a relevant effect in treating both cases, broadening the breadth of knowledge to guide future research on this topic.
C1 [Chakraborty, Sanjib] JSS Acad Higher Educ & Res, JSS Coll Pharm, Dept Pharmaceut Chem, Ooty 643001, Tamil Nadu, India.
   [Bogadi, Subhasri; Pamu, Divya; Karri, Veera Venkata Satyanarayana Reddy] JSS Acad Higher Educ & Res, JSS Coll Pharm, Dept Pharmaceut, Ooty 643001, Tamil Nadu, India.
   [Booker, Anthony] Univ Westminister, Res Ctr Optimal Hlth, Sch Life Sci, London, England.
   [Rolfe, Vivian] Pukka Herbs Ltd, Keynsham, England.
   [Mohankumar, Suresh] Swansea Univ, Pharm Swansea Univ, Med Sch, Swansea SA2 8PP, Wales.
C3 JSS Academy of Higher Education & Research; JSS College of Pharmacy,
   Ooty; JSS Academy of Higher Education & Research; JSS College of
   Pharmacy, Ooty; University of Westminster; Swansea University
RP Mohankumar, S (corresponding author), Swansea Univ, Pharm Swansea Univ, Med Sch, Swansea SA2 8PP, Wales.
EM s.k.mohankumar@swansea.ac.uk
RI Karri, Veera/I-9070-2014
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NR 45
TC 3
Z9 3
U1 0
U2 5
PU NATL INST SCIENCE COMMUNICATION-NISCAIR
PI NEW DELHI
PA DR K S KRISHNAN MARG, PUSA CAMPUS, NEW DELHI 110 012, INDIA
SN 0301-1208
EI 0975-0959
J9 INDIAN J BIOCHEM BIO
JI Indian J. Biochem. Biophys.
PD FEB
PY 2023
VL 60
IS 2
BP 129
EP 140
DI 10.56042/ijbb.v60i2.70738
PG 12
WC Biochemistry & Molecular Biology; Biophysics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics
GA C6UP1
UT WOS:000963247200005
OA gold, Green Accepted
DA 2025-06-11
ER

PT J
AU Fields, ND
   Narayan, KMV
   Ranjani, H
   Staimez, LR
   Anjana, RM
   Patel, SA
   Mohan, V
   Ali, MK
   Weber, MB
AF Fields, Nicole D.
   Narayan, K. M. Venkat
   Ranjani, Harish
   Staimez, Lisa R.
   Anjana, Ranjit Mohan
   Patel, Shivani A.
   Mohan, Viswanathan
   Ali, Mohammed K.
   Weber, Mary Beth
TI Perceived stress and progression of cardiometabolic risk factors among
   South Asians with prediabetes in a lifestyle intervention trial
SO PRIMARY CARE DIABETES
LA English
DT Article
DE Prediabetes; Cardiometabolic health; South Asians; DCLIP; Lifestyle
   modificationtrial; Perceived stress
ID DIABETES PREVENTION; FOLLOW-UP
AB Aims: To examine associations between perceived stress and cardiometabolic risk factors in South Asians with prediabetes and assess whether a diabetes prevention program mitigates the impact of stress on cardiometabolic health. Methods: We conducted a secondary analysis of the Diabetes Community Lifestyle Improvement Program, a lifestyle modification trial for diabetes prevention in India (n = 564). Indicators for cardiometabolic health (weight, waist circumference, blood pressure, glucose, HbA1c, and lipids) were measured at each visit while perceived stress was assessed via questionnaire at baseline. Multivariable linear regression assessed associations between stress and cardiometabolic parameters at baseline and 3-year follow up. Results: At baseline, perceived stress was associated with higher weight (b=0.16; 95% CI: 0.04, 0.29) and waist circumference (b=0.11; 95% CI: 0.01, 0.21) but lower 30-minute postload glucose (b=-0.44; 95% CI: -0.76, -0.14) and LDL cholesterol (b=-0.40; 95% CI: -0.76, -0.03). Over the study period, perceived stress was associated with weight gain (b=0.20; 95% CI: 0.07, 0.33) and increased waist circumference (b=0.14; 95% CI: 0.04, 0.24). Additionally, higher perceived stress was associated with lower HDL cholesterol among the control arm (p(interaction) = 0.02). Conclusions: Baseline stress was associated with negative cardiometabolic risk factor outcomes over time in those with prediabetes.
C1 [Fields, Nicole D.; Patel, Shivani A.] Emory Univ, Dept Epidemiol, 1518 Clifton Rd NE,CNR 2038, Atlanta, GA 30322 USA.
   [Fields, Nicole D.; Narayan, K. M. Venkat; Staimez, Lisa R.; Patel, Shivani A.; Ali, Mohammed K.; Weber, Mary Beth] Emory Univ, Hubert Dept Global Hlth, 1518 Clifton Rd NE, Atlanta, GA 30322 USA.
   [Ranjani, Harish; Anjana, Ranjit Mohan; Mohan, Viswanathan] Madras Diabet Res Fdn, Chennai 600086, India.
   [Anjana, Ranjit Mohan; Mohan, Viswanathan] Dr Mohans Diabet Special Ctr, IDF Ctr Excellence Diabet Care, Chennai 600086, India.
   [Ali, Mohammed K.] Emory Univ, Dept Family & Prevent Med, Sch Med, 100 Woodruff Circle, Atlanta, GA 30322 USA.
C3 Emory University; Emory University; Madras Diabetes Research Foundation;
   Emory University
RP Fields, ND (corresponding author), Emory Univ, Dept Epidemiol, 1518 Clifton Rd NE,CNR 2038, Atlanta, GA 30322 USA.
EM nfield5@emory.edu
RI Viswanathan, Mohan/C-2321-2009; Narayan, K.M./J-9819-2012; Weber,
   Mary/AAB-2028-2020; Staimez, Lisa/P-1898-2018
OI Ranjani, Harish/0000-0002-1521-7398; Mohan,
   Viswanathan/0000-0001-5038-6210; Fields, Nicole/0000-0001-6251-8356
FU International Diabetes Federation [LT07 - 115]; Lilly Diabetes; Emory
   Global Health Institute at Emory University, Atlanta, GA; National
   Institute of Digestive Diabetes and Kidney Diseases [P30DK111024];
   National Heart, Lung, and Blood Institute [T32HL130025]
FX The D-CLIP study was supported by a BRIDGES Grant (No: LT07 - 115) from
   the International Diabetes Federation and an educational grant from
   Lilly Diabetes. Additional support was provided by the Emory Global
   Health Institute at Emory University, Atlanta, GA and the National
   Institute of Digestive Diabetes and Kidney Diseases (P30DK111024).
   N.D.F. was supported by the National Heart, Lung, and Blood Institute
   (T32HL130025) .
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NR 24
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 1751-9918
EI 1878-0210
J9 PRIM CARE DIABETES
JI Prim. Care Diabetes
PD APR
PY 2024
VL 18
IS 2
BP 183
EP 187
DI 10.1016/j.pcd.2023.12.002
EA APR 2024
PG 5
WC Endocrinology & Metabolism; Primary Health Care
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; General & Internal Medicine
GA RO2Z6
UT WOS:001228552100001
PM 38177017
DA 2025-06-11
ER

PT J
AU Ohaeri, JU
   Akanji, AO
AF Ohaeri, Jude U.
   Akanji, Abayomi O.
TI Metabolic Syndrome in Severe Mental Disorders
SO METABOLIC SYNDROME AND RELATED DISORDERS
LA English
DT Article
ID DRUG-NAIVE PATIENTS; INDUCED WEIGHT-GAIN; 2ND-GENERATION ANTIPSYCHOTICS;
   INSULIN-RESISTANCE; PHYSICAL HEALTH; DOUBLE-BLIND; ATYPICAL
   ANTIPSYCHOTICS; GENE POLYMORPHISMS; DIABETES-MELLITUS; BIPOLAR DISORDER
AB The concept of metabolic syndrome in psychiatry provides a united front for confronting a series of metabolic changes that are predictive of cardiovascular disease (CVD) and type 2 diabetes mellitus (T2DM), which are highly prevalent in severe mental disorders (SMDs), such as schizophrenia, bipolar disorders, and severe depression. This review attempts to answer the following questions: (1) Is there evidence of significantly increased risk of metabolic syndrome in SMDs? (2) How is this evidence explained by stress theory and functional polymorphism? (3) What role can psychopharmacology and psychosocial therapies play in minimizing the problem? We have done a historical review using related literature from Medline. Compared with the general population, metabolic syndrome is two to three times more common in SMDs. The evidence for this predates the era of antipsychotic drugs. Altered glucose metabolism and dyslipidemia seem to be integral to SMDs. However, major psychotropic drugs are associated with metabolic syndrome, because of their activity at the appetite-stimulating receptors. SMDs seem to trigger a pathogenic cycle that fuels metabolic syndrome. To explain these findings, a neural diathesis-stress model has been proposed. Furthermore, candidate genes associated with receptors for weight gain are implicated. Using metformin (>= 750 mg/day) may significantly reduce metabolic risks, and the data support consideration of this intervention for psychiatric patients taking antipsychotics. The obstacles to the implementation of the available guidelines for monitoring metabolic effects and changing unhelpful lifestyles need to be overcome by making monitoring mandatory and integration of physical exercise into routine care. Drug development and genotyping for the risk factors are future solutions.
C1 [Ohaeri, Jude U.] Psychol Med Hosp Kuwait, Dept Psychiat, Safat 13041, Kuwait.
   [Akanji, Abayomi O.] Kuwait Univ, Fac Med, Dept Pathol, Safat, Kuwait.
C3 Kuwait University
RP Ohaeri, JU (corresponding author), Psychol Med Hosp Kuwait, Dept Psychiat, Gamal Abdul Naser Rd,POB 4081, Safat 13041, Kuwait.
EM judeohaeri@hotmail.com
RI Akanji, Abayomi/AAY-4732-2021
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NR 90
TC 31
Z9 32
U1 0
U2 17
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-4196
EI 1557-8518
J9 METAB SYNDR RELAT D
JI Metab. Syndr. Relat. Disord.
PD APR
PY 2011
VL 9
IS 2
BP 91
EP 98
DI 10.1089/met.2010.0053
PG 8
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 741EY
UT WOS:000288847200003
PM 20964513
DA 2025-06-11
ER

PT J
AU Imaizumi, T
   Toda, T
   Maekawa, M
   Sakurai, D
   Hagiwara, Y
   Yoshida, Y
   Ando, M
   Maruyama, S
AF Imaizumi, Takahiro
   Toda, Takuya
   Maekawa, Michitaka
   Sakurai, Daisuke
   Hagiwara, Yuta
   Yoshida, Yasuko
   Ando, Masahiko
   Maruyama, Shoichi
TI Identifying high-risk population of depression: association between
   metabolic syndrome and depression using a health checkup and claims
   database
SO SCIENTIFIC REPORTS
LA English
DT Article
ID CARDIOVASCULAR-DISEASE; ALCOHOL-CONSUMPTION; MENTAL-DISORDERS;
   PREVALENCE; MORTALITY; INSOMNIA; ANXIETY; CANCER; HEART; METAANALYSIS
AB Depression and metabolic syndrome (MetS) are correlated, leading to an increased healthcare burden and decreased productivity. We aimed to investigate the association between MetS-related factors and depression using a health checkup and claims database. Individuals aged 18-75 years who underwent health examinations between 2014 and 2019 were enrolled in the study. Among 76,277 participants, "ever" and "incident" antidepressant users exhibited worse metabolic profiles and were more likely to be prescribed hypnotics and anxiolytics than "never" users. In a nested case-control study with a 1:10 ratio of incident users to controls, MetS was associated with incident antidepressant use (odds ratio, 1.53 [95% confidence interval 1.24-1.88]) adjusted for lifestyle information obtained from a self-administered questionnaire, medical history, and medications. Other metabolic traits also showed significant associations: body mass index (1.04 [1.02-1.06]), abdominal circumference per 10 cm (1.17 [1.08-1.27]), high blood pressure (1.17 [1.00-1.37]), glucose intolerance (1.29 [1.05-1.58]), and dyslipidemia (1.27 [1.08-1.51]). A bodyweight increase > 10 kg from age 20 years (1.46 [1.25-1.70]) was also significantly associated with incident antidepressant use. In conclusion, metabolic abnormalities were associated with incident antidepressant use and can be useful in identifying populations at high risk of depression.
C1 [Imaizumi, Takahiro; Ando, Masahiko] Nagoya Univ Hosp, Dept Adv Med, Showa Ku, 65 Tsuruma Cho, Nagoya, Aichi 4648550, Japan.
   [Imaizumi, Takahiro; Maruyama, Shoichi] Nagoya Univ, Grad Sch Med, Dept Nephrol, Showa Ku, 65 Tsuruma Cho, Nagoya, Aichi 4648550, Japan.
   [Toda, Takuya; Sakurai, Daisuke; Hagiwara, Yuta] Prevent Co Ltd, Nagoya, Aichi, Japan.
   [Maekawa, Michitaka] Hidamari Kokoro Clin, Ama, Japan.
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C3 Nagoya University; Nagoya University; Nagoya University
RP Imaizumi, T (corresponding author), Nagoya Univ Hosp, Dept Adv Med, Showa Ku, 65 Tsuruma Cho, Nagoya, Aichi 4648550, Japan.; Imaizumi, T; Maruyama, S (corresponding author), Nagoya Univ, Grad Sch Med, Dept Nephrol, Showa Ku, 65 Tsuruma Cho, Nagoya, Aichi 4648550, Japan.
EM imaizumi18@med.nagoya-u.ac.jp; marus@med.nagoya-u.ac.jp
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NR 50
TC 4
Z9 4
U1 1
U2 2
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD NOV 3
PY 2022
VL 12
IS 1
AR 18577
DI 10.1038/s41598-022-22048-9
PG 11
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 5X7HI
UT WOS:000878770000022
PM 36329095
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Sugimoto, K
   Yamada, T
   Kitazawa, A
   Fukuda, Y
AF Sugimoto, Kumi
   Yamada, Takuya
   Kitazawa, Atsushi
   Fukuda, Yoshiharu
TI Metabolic syndrome and depression: evidence from a cross-sectional study
   of real-world data in Japan
SO ENVIRONMENTAL HEALTH AND PREVENTIVE MEDICINE
LA English
DT Article
DE Metabolic syndrome; Depression; Real-world data; Health claim data;
   Health checkup data; Cross-sectional study
ID ASSOCIATION; METAANALYSIS; HYPERTENSION; RISK
AB Background: Both metabolic syndrome (MetS) and depression are high priority health problems, especially for working age. Numerous studies have explored the link between metabolic syndrome and depression; however, not all of them have consistently demonstrated an association. The objective of this study was to determine whether there is an association between MetS and depression by analyzing extensive real -world data (RWD). Methods: Our data was drawn from insurance claims and health checkups of local government o ffi cials across all prefectures in Japan except for Tokyo in the 2019 fi scal year. According to the number of months with diagnosis of depression and prescription of antidepressants, the study participants were classi fi ed into the following categories: Certainly not Depression (CN), Possibly not Depression (PN), Possible Depression (PD), and Certain Depression (CD). Associations between MetS and its components - visceral obesity, hypertension, hyperlipidemia, and diabetes - and these categories of depression were analyzed by logistic regression. Results: The depression categories of the 130,059 participants were as follows: CN 85.2%; PN 6.9%; PD 3.9%; and CD 4.1%. For men, the adjusted odds ratio (AOR) for MetS were PN 0.94 (95% CI: 0.86 - 1.02), PD 1.31 (1.19 - 1.43), and CD 1.63 (1.50 - 1.76), with reference to CN. For women, AOR of MetS were PN 1.10 (0.91 - 1.32), PD 1.54 (1.24 - 1.91), and CD 2.24 (1.81 - 2.78). Among the MetS components, visceral obesity, hyperlipidemia, and diabetes were signi fi cantly associated with depression categories. Conclusions: In this study, we found a signi fi cant association between MetS and depression, this association being similar to that previously reported. Our fi ndings provide robust evidence for linkage between MetS and depression, suggesting that analysis of RWD is useful for providing concrete evidence.
C1 [Sugimoto, Kumi; Yamada, Takuya; Kitazawa, Atsushi; Fukuda, Yoshiharu] Teikyo Univ, Grad Sch Publ Hlth, 2-11-1 Kaga,Itabashi Ku, Tokyo 1738605, Japan.
C3 Teikyo University
RP Sugimoto, K (corresponding author), Teikyo Univ, Grad Sch Publ Hlth, 2-11-1 Kaga,Itabashi Ku, Tokyo 1738605, Japan.
EM kumi.sugimoto@teikyo-u.ac.jp
FU Teikyo University; Subject health insurance association
FX This study was funded from the agreement of Teikyo University and the
   subject health insurance association.
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U2 3
PU JAPANESE SOC HYGIENE
PI Kyoto-city
PA 146 Nishioji-cho, Shimodachiuri-dori, Kamigyo-ku,, Kyoto-city, Kyoto,
   JAPAN
SN 1342-078X
EI 1347-4715
J9 ENVIRON HEALTH PREV
JI Environ. Health Prev.
PY 2024
VL 29
DI 10.1265/ehpm.23-00369
PG 8
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA XS0O0
UT WOS:001263550600001
PM 38960635
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Prasun, P
AF Prasun, Pankaj
TI Mitochondrial dysfunction in metabolic syndrome
SO BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
LA English
DT Review
DE Mitochondria; Obesity; Diabetes; Diabetes mellitus; Metabolic syndrome
ID ACTIVATED PROTEIN-KINASE; ENERGY SENSING NETWORK; SKELETAL-MUSCLE;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; PGC-1-ALPHA; OBESITY; BIOGENESIS;
   ADIPOKINES; EXERCISE
AB Metabolic syndrome is co-occurrence of obesity, insulin resistance, atherogenic dyslipidemia (high triglyceride, low high density lipoprotein cholesterol), and hypertension. It is a global health problem. An estimated 20%-30% of adults of the world have metabolic syndrome. Metabolic syndrome is associated with increased risk of type 2 diabetes mellitus, nonalcoholic fatty liver disease, myocardial infarction, and stroke. Thus, it is a major cause of morbidity and mortality worldwide. However, molecular pathogenesis of metabolic syndrome is not well known. Recently, there has been interest in the role of mitochondria in pathogenesis of metabolic problems such as obesity, metabolic syndrome, and type 2 diabetes mellitus. Mitochondrial dysfunction contributes to the oxidative stress and systemic inflammation seen in metabolic syndrome. Role of mitochondria in the pathogenesis of metabolic syndrome is intriguing but far from completely understood. However, a better understanding will be very rewarding as it may lead to novel approaches to control this major public health problem. This brief review explores pathogenesis of metabolic syndrome from a mitochondrial perspective.
C1 [Prasun, Pankaj] Icahn Sch Med Mt Sinai, Dept Genet & Genom Sci, One Gustave L Levy Pl Box 1497, New York, NY 10029 USA.
C3 Icahn School of Medicine at Mount Sinai
RP Prasun, P (corresponding author), Icahn Sch Med Mt Sinai, Dept Genet & Genom Sci, One Gustave L Levy Pl Box 1497, New York, NY 10029 USA.
EM Pankaj.Prasun@mssm.edu
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NR 105
TC 235
Z9 243
U1 16
U2 126
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29a, 1043 NX AMSTERDAM, NETHERLANDS
SN 0925-4439
EI 1879-260X
J9 BBA-MOL BASIS DIS
JI Biochim. Biophys. Acta-Mol. Basis Dis.
PD OCT 1
PY 2020
VL 1866
IS 10
AR 165838
DI 10.1016/j.bbadis.2020.165838
PG 6
WC Biochemistry & Molecular Biology; Biophysics; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Cell Biology
GA NA7FW
UT WOS:000559983700033
PM 32428560
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Shirazpour, S
   Khaksari, M
   Gaini, AA
   Bashiri, H
   Khoramipour, K
   Rafie, F
AF Shirazpour, Sara
   Khaksari, Mohammad
   Gaini, Abbas Ali
   Bashiri, Hamideh
   Khoramipour, Kayvan
   Rafie, Forouzan
TI Can resisted swimming exercise substitute for the protective effects of
   estrogen on cardiometabolic risk factors in obese postmenopausal rat
   model?
SO IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
LA English
DT Article
DE 17 beta-estradiol; Bilateral ovariectomies; High-fat diet; Oxidative
   stress; Swimming
ID OXIDATIVE STRESS; LIPID PROFILE; INSULIN-RESISTANCE; FAT; COMBINATION;
   DYSFUNCTION; DISEASE; ACID; DIET; CARDIOPROTECTION
AB Objective(s): Following our previous studies on the anti-obesity and cardioprotective effects of 17-beta estradiol (E2), this study was designed to determine the effects of Resisted swimming (RSW) training and E2 (alone and in combination) on cardiometabolic risk factors in an obese postmenopausal rat model. Materials and Methods: Female ovariectomized rats (OVX) were given a standard diet (SD) or a 60% high-fat diet (HFD) for 16 weeks and were divided into two groups: SD and HFD. The rats were divided into ten groups to assess the effects of 8 weeks of E2 (1 mg/kg, IP) administration and RSW (5 days a week) on cardiometabolic risk factors. Parameters including body weight, BMI, visceral fat, blood glucose (BG), and cardiac oxidative stress were assessed 72 hr after the last swimming session. Results: HFD increased body weight, BMI, visceral fat, and BG levels in OVX rats. Additionally, it negatively affected the lipid profile and cardiac oxidative stress, but both E2 and RSW reduced these parameters in HFD-fed OVX rats. Although RSW and E2 equally prevented these changes, swimming was more effective than estrogen in increasing HDL levels in the SD group. The combination of E2 and RSW had a more significant effect on modulating glucose, TAC, TG, and HDL indices than the individual treatments. Conclusion: Overall, RSW ameliorates cardiometabolic risk factors in postmenopausal conditions caused by obesity, probably by modulating cardiac oxidative stress. It is also an effective non- pharmacological treatment for E2 substitution.
C1 [Shirazpour, Sara; Khaksari, Mohammad; Khoramipour, Kayvan] Kerman Univ Med Sci, Fac Med, Dept Physiol, Kerman, Iran.
   [Khaksari, Mohammad] Kerman Univ Med Sci, Inst Neuropharmacol, Physiol Res Ctr, Kerman, Iran.
   [Gaini, Abbas Ali] Univ Tehran, Dept Exercise Physiol, Tehran, Iran.
   [Bashiri, Hamideh; Rafie, Forouzan] Kerman Univ Med Sci, Inst Neuropharmacol, Neurosci Res Ctr, Kerman, Iran.
   [Khoramipour, Kayvan] Miguel de Cervantes European Univ UEMC, Dept Hlth Sci, I HeALTH Strateg Res Grp, Valladolid 47012, Spain.
   [Rafie, Forouzan] Emory Univ, Div Geriatr & Gerontol, Sch Med, Atlanta, GA USA.
C3 Kerman University of Medical Sciences; Kerman University of Medical
   Sciences; University of Tehran; Kerman University of Medical Sciences;
   Emory University
RP Khaksari, M (corresponding author), Kerman Univ Med Sci, Fac Med, Dept Physiol, Kerman, Iran.
EM mkhaksari@kmu.ac.ir
RI Bashiri, Hamideh/AAU-2552-2020; Haddad, Mohammad/AAB-9025-2019
FU Physiology Research Center of Kerman University of Medical Sciences,
   Iran [IR.KMU.AEC.1402.052]
FX The Physiology Research Center of Kerman University of Medical Sciences,
   Iran, financially supported this work (Grant No. IR.KMU.AEC.1402.052) .
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NR 60
TC 0
Z9 0
U1 1
U2 1
PU MASHHAD UNIV MED SCIENCES
PI MASHHAD
PA VICE-CHANCELLOR FOR RES CTR OFF IJBMS, DANESHGAH ST, PO BOX 9138813944 -
   445, MASHHAD, 00000, IRAN
SN 2008-3866
EI 2008-3874
J9 IRAN J BASIC MED SCI
JI Iran. J. Basic Med. Sci.
PD JUN
PY 2025
VL 28
IS 6
BP 718
EP 727
DI 10.22038/ijbms.2025.82005.17745
PG 10
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA 0FW2E
UT WOS:001446383700004
PM 40343300
DA 2025-06-11
ER

PT J
AU Hunter, I
   Soler, A
   Joseph, G
   Hutcheson, B
   Bradford, C
   Zhang, FF
   Potter, B
   Proctor, S
   Rocic, P
AF Hunter, Ian
   Soler, Amanda
   Joseph, Gregory
   Hutcheson, Brenda
   Bradford, Chastity
   Zhang, Frank Fan
   Potter, Barry
   Proctor, Spencer
   Rocic, Petra
TI Cardiovascular function in male and female JCR:LA-cp rats: effect of
   high-fat/high-sucrose diet
SO AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
LA English
DT Article
DE metabolic syndrome; Western diet; cardiovascular disease; sex
   differences; oxidative stress
ID CORONARY COLLATERAL GROWTH; METABOLIC SYNDROME; OXIDATIVE STRESS;
   HIGH-FAT; HIGH-CARBOHYDRATE; ACE-INHIBITOR; VASCULAR WALL;
   ANIMAL-MODELS; WESTERN DIET; ESTROGEN
AB Thirty percent of the world population is diagnosed with metabolic syndrome. High-fat/high-sucrose (HF/HS) diet (Western diet) correlates with metabolic syndrome prevalence. We characterized effects of the HF/HS diet on vascular (arterial stiffness, vasoreactivity, and coronary collateral development) and cardiac (echocardiography) function, oxidative stress, and inflammation in a rat model of metabolic syndrome (JCR rats). Furthermore, we determined whether male versus female animals were affected differentially by the Western diet. Cardiovascular function in JCR male rats was impaired versus normal Sprague-Dawley (SD) rats. HF/HS diet compromised cardiovascular (dys) function in JCR but not SD male rats. In contrast, cardiovascular function was minimally impaired in JCR female rats on normal chow. However, cardiovascular function in JCR female rats on the HF/HS diet deteriorated to levels comparable to JCR male rats on the HF/HS diet. Similarly, oxidative stress was markedly increased in male but not female JCR rats on normal chow but was equally exacerbated by the HF/HS diet in male and female JCR rats. These results indicate that the Western diet enhances oxidative stress and cardiovascular dysfunction in metabolic syndrome and eliminates the protective effect of female sex on cardiovascular function, implying that both males and females with metabolic syndrome are at equal risk for cardiovascular disease.
   NEW & NOTEWORTHY Western diet abolished protective effect of sex against cardiovascular disease (CVD) development in premenopausal animals with metabolic syndrome. Western diet accelerates progression of CVD in male and female animals with preexisting metabolic syndrome but not normal animals. Exacerbation of baseline oxidative stress correlates with accelerated progression of CVD in metabolic syndrome animals on Western diet.
C1 [Hunter, Ian; Soler, Amanda; Joseph, Gregory; Hutcheson, Brenda; Zhang, Frank Fan; Rocic, Petra] New York Med Coll, Dept Pharmacol, BSB 502,15 Dana Rd, Valhalla, NY 10595 USA.
   [Bradford, Chastity] Tuskegee Univ, Dept Biol, Tuskegee, AL 36088 USA.
   [Potter, Barry] Louisiana State Univ, Hlth Sci Ctr, Dept Physiol, New Orleans, LA USA.
   [Proctor, Spencer] Univ Alberta, Alberta Inst Human Nutr, Metab & Cardiovasc Dis Lab, Edmonton, AB, Canada.
C3 New York Medical College; Tuskegee University; Louisiana State
   University System; Louisiana State University Health Sciences Center New
   Orleans; University of Alberta
RP Rocic, P (corresponding author), New York Med Coll, Dept Pharmacol, BSB 502,15 Dana Rd, Valhalla, NY 10595 USA.
EM petra_rocic@nymc.edu
RI Proctor, Spencer/F-2774-2012
OI Bradford, Chastity/0000-0001-7460-6134; Rocic,
   Petra/0000-0002-5781-3075; Proctor, Spencer/0000-0002-7597-5262
FU National Heart, Lung, and Blood Institute [R01-HL-093052]
FX P. Rocic was supported by National Heart, Lung, and Blood Institute
   Grant R01-HL-093052.
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NR 47
TC 23
Z9 27
U1 0
U2 16
PU AMER PHYSIOLOGICAL SOC
PI Rockville
PA 6120 Executive Blvd, Suite 600, Rockville, MD, UNITED STATES
SN 0363-6135
EI 1522-1539
J9 AM J PHYSIOL-HEART C
JI Am. J. Physiol.-Heart Circul. Physiol.
PD APR
PY 2017
VL 312
IS 4
BP H742
EP H751
DI 10.1152/ajpheart.00535.2016
PG 10
WC Cardiac & Cardiovascular Systems; Physiology; Peripheral Vascular
   Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Physiology
GA EQ2AO
UT WOS:000397870900011
PM 28087518
OA Green Published
DA 2025-06-11
ER

PT J
AU Pausova, Z
   Paus, T
   Abrahamowicz, M
   Bernard, M
   Gaudet, D
   Leonard, G
   Peron, M
   Pike, GB
   Richer, L
   Séguin, JR
   Veillette, S
AF Pausova, Zdenka
   Paus, Tomas
   Abrahamowicz, Michal
   Bernard, Manon
   Gaudet, Daniel
   Leonard, Gabriel
   Peron, Michel
   Pike, G. Bruce
   Richer, Louis
   Seguin, Jean R.
   Veillette, Suzanne
TI Cohort Profile: The Saguenay Youth Study (SYS)
SO INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
LA English
DT Article
ID MATERNAL CIGARETTE-SMOKING; PRENATAL-EXPOSURE; BLOOD-PRESSURE;
   CARDIOMETABOLIC RISK; VISCERAL ADIPOSITY; METABOLIC SYNDROME; ARTERY
   PRESSURE; WHITE-MATTER; JEAN QUEBEC; FAT INTAKE
AB The Saguenay Youth Study (SYS) is a two-generational study of adolescents and their parents (n = 1029 adolescents and 962 parents) aimed at investigating the aetiology, early stages and trans-generational trajectories of common cardiometabolic and brain diseases. The ultimate goal of this study is to identify effective means for increasing healthy life expectancy. The cohort was recruited from the genetic founder population of the Saguenay Lac St Jean region of Quebec, Canada. The participants underwent extensive (15-h) phenotyping, including an hour-long recording of beat-by-beat blood pressure, magnetic resonance imaging of the brain and abdomen, and serum lipidomic profiling with LC-ESI-MS. All participants have been genonne-wide genotyped (with similar to 8 M imputed single nucleotide polymorphisnns) and a subset of them (144 adolescents and their 288 parents) has been genonne-wide epityped (whole blood DNA, Infinium HunnanMethylation450K BeadChip). These assessments are complemented by a detailed evaluation of each participant in a number of domains, including cognition, mental health and substance use, diet, physical activity and sleep, and family environment. The data collection took place during 2003-12 in adolescents (full) and their parents (partial), and during 2012-15 in parents (full). All data are available upon request.
C1 [Pausova, Zdenka; Bernard, Manon] Univ Toronto, Hosp Sick Children, Toronto, ON, Canada.
   [Pausova, Zdenka; Bernard, Manon] Univ Toronto, Dept Physiol, Toronto, ON, Canada.
   [Pausova, Zdenka; Bernard, Manon] Univ Toronto, Dept Nutr Sci, Toronto, ON, Canada.
   [Paus, Tomas] Univ Toronto, Rotman Res Inst, Toronto, ON, Canada.
   [Paus, Tomas] Univ Toronto, Dept Psychol, Toronto, ON, Canada.
   [Abrahamowicz, Michal] Univ Toronto, Dept Psychiat, Toronto, ON, Canada.
   [Paus, Tomas] Child Mind Inst, New York, NY USA.
   [Abrahamowicz, Michal] McGill Univ, Dept Epidemiol Biostat & Occupat Hlth, Montreal, PQ, Canada.
   [Gaudet, Daniel] Univ Montreal, Community Genom Ctr, Chicoutimi, PQ, Canada.
   [Leonard, Gabriel] McGill Univ, Montreal Neurol Inst, Montreal, PQ, Canada.
   [Peron, Michel] Univ Quebec Chicoutimi, Dept Human Sci, Chicoutimi, PQ, Canada.
   [Pike, G. Bruce] Univ Calgary, Hotchkiss Brain Inst, Calgary, BC, Canada.
   [Richer, Louis] Univ Quebec Chicoutimi, Dept Hlth Sci, Chicoutimi, PQ, Canada.
   [Seguin, Jean R.] Univ Montreal, St Justine Hosp Res Ctr, Montreal, PQ, Canada.
   [Seguin, Jean R.] Univ Montreal, Dept Psychiat, Montreal, PQ, Canada.
C3 University of Toronto; Hospital for Sick Children (SickKids); University
   of Toronto; University of Toronto; University of Toronto; Baycrest;
   University of Toronto; University of Toronto; McGill University;
   Universite de Montreal; McGill University; University of Quebec;
   University of Quebec Chicoutimi; University of Calgary; University of
   Quebec; University of Quebec Chicoutimi; Universite de Montreal; Centre
   Hospitalier Universitaire Sainte-Justine; Universite de Montreal
RP Pausova, Z (corresponding author), Univ Toronto, Hosp Sick Children, Dept Physiol, Peter Gilgan Ctr Res & Learning, 686 Bay St,10-9705, Toronto, ON M5G 0A4, Canada.; Pausova, Z (corresponding author), Univ Toronto, Hosp Sick Children, Dept Nutr Sci, Peter Gilgan Ctr Res & Learning, 686 Bay St,10-9705, Toronto, ON M5G 0A4, Canada.; Paus, T (corresponding author), Univ Toronto, Rotman Res Inst, Dept Psychol, 3560 Bathurst St, Toronto, ON M6A 2E1, Canada.; Paus, T (corresponding author), Univ Toronto, Rotman Res Inst, Dept Psychiat, 3560 Bathurst St, Toronto, ON M6A 2E1, Canada.
EM zdenka.pausova@sickkids.ca; tpaus@research.baycrest.org
RI Poustka, Luise/D-9299-2017; Brais, Bernard/Y-3910-2019; Pike,
   Bruce/K-5562-2014; Seguin, Jean/B-5349-2008
OI Pike, Bruce/0000-0001-8924-683X; Seguin, Jean/0000-0003-3359-6202
FU Canadian Institutes of Health Research; Heart and Stroke Foundation of
   Canada; Canadian Foundation for Innovation
FX The Saguenay Youth Study has been funded by the Canadian Institutes of
   Health Research (T.P., Z.P.), Heart and Stroke Foundation of Canada
   (Z.P.) and the Canadian Foundation for Innovation (Z.P.).
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NR 93
TC 45
Z9 52
U1 0
U2 9
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0300-5771
EI 1464-3685
J9 INT J EPIDEMIOL
JI Int. J. Epidemiol.
PD APR
PY 2017
VL 46
IS 2
AR e19
DI 10.1093/ije/dyw023
PG 14
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA EX1PD
UT WOS:000402996000019
PM 27018016
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU McClain, AC
   Xiao, RS
   Tucker, KL
   Falcón, LM
   Mattei, J
AF McClain, Amanda C.
   Xiao, Rui S.
   Tucker, Katherine L.
   Falcon, Luis M.
   Mattei, Josiemer
TI Depressive symptoms and allostatic load have a bidirectional association
   among Puerto Rican older adults
SO PSYCHOLOGICAL MEDICINE
LA English
DT Article
DE Allostatic load; depression; depressive symptoms; Hispanics; Latinos;
   Puerto Ricans
ID SUBTHRESHOLD DEPRESSION; CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME;
   LATE-LIFE; DIVERSE BACKGROUNDS; HEALTH BEHAVIORS; BIOLOGICAL RISK;
   MENTAL-HEALTH; STRESS; INFLAMMATION
AB Background Depression is strongly associated with chronic disease; yet, the direction of this relationship is poorly understood. Allostatic load (AL) provides a framework for elucidating depression-disease pathways. We aimed to investigate bidirectional, longitudinal associations of baseline depressive symptoms or AL with 5-year AL or depressive symptoms, respectively. Methods Data were from baseline, 2-year, and 5-year visits of 620 adults (45-75 years) enrolled in the Boston Puerto Rican Health Study. The Center for Epidemiology Studies Depression (CES-D) scale (0-60) captured depressive symptoms, which were categorized at baseline as low (<8), subthreshold (8-15), or depression-likely (> 16) symptoms. AL was calculated from 11 parameters of biological functioning, representing five physiological systems. Baseline AL scores were categorized by the number of dysregulated parameters: low (0-2), moderate (3-5), or high (> 6) AL. Multivariable, multilevel random intercept and slope linear regression models were used to examine associations between 3-category baseline CES-D score and 5-year continuous AL score, and between baseline 3-category AL and 5-year continuous CES-D score. Results Baseline subthreshold depressive symptoms [(mean (95% CI)): 4.8 (4.5-5.2)], but not depression-likely symptoms [4.5 (4.2-4.9)], was significantly associated with higher 5-year AL scores, compared to low depressive symptoms [4.3 (3.9-4.7)]. Baseline high AL [19.4 (17.6-21.2)], but not low AL [18.5 (16.5-20.6)], was significantly associated with higher 5-year CES-D score, compared to baseline moderate AL [16.9 (15.3-18.5)]. Conclusions Depressive symptoms and AL had a bi-directional relationship over time, indicating a nuanced pathway linking depression with chronic diseases among a minority population.
C1 [McClain, Amanda C.] San Diego State Univ, Sch Exercise & Nutr Sci, San Diego, CA 92182 USA.
   [Xiao, Rui S.] IQVIA, Real World Evidence, Cambridge, MA USA.
   [Tucker, Katherine L.] Univ Massachusetts, Dept Biomed & Nutr Sci, Lowell, MA USA.
   [Falcon, Luis M.] Univ Massachusetts, Coll Fine Arts Humanities & Social Sci, Lowell, MA USA.
   [Mattei, Josiemer] Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA.
C3 California State University System; San Diego State University; IQVIA;
   University of Massachusetts System; University of Massachusetts Lowell;
   University of Massachusetts System; University of Massachusetts Lowell;
   Harvard University; Harvard T.H. Chan School of Public Health
RP Mattei, J (corresponding author), Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA.
EM jmattei@hsph.harvard.edu
RI McClain, Amanda/J-1158-2019; Tucker, Katherine/A-4545-2010; Falcon,
   Luis/C-1237-2009; Mattei, Josiemer/H-1800-2016
OI Tucker, Katherine/0000-0001-7640-662X; Falcon, Luis
   M./0000-0002-2476-5046; Mattei, Josiemer/0000-0001-5424-8245
FU National Institutes of Health (NIH)-National Institute on Aging
   [P01-AG023394]; US Department of Agriculture, Agriculture Research
   Institute [58-1950-7-707]; NIH-National Heart Lung and Blood (NHLBI)
   Mentored Research Scientist Development Award [K01-HL150406]; NIH-NHLBI
   Mentored Career Development Award [K01-HL120951]
FX Y The Boston Puerto Rican Health Study was supported by the National
   Institutes of Health (NIH)-National Institute on Aging (P01-AG023394)
   and by the US Department of Agriculture, Agriculture Research Institute
   (58-1950-7-707). Dr Amanda C. McClain received support for this study
   from a NIH-National Heart Lung and Blood (NHLBI) Mentored Research
   Scientist Development Award (K01-HL150406). Dr Josiemer Mattei received
   support for this study from a NIH-NHLBI Mentored Career Development
   Award to Promote Faculty Diversity (K01-HL120951).
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NR 93
TC 8
Z9 12
U1 2
U2 6
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0033-2917
EI 1469-8978
J9 PSYCHOL MED
JI Psychol. Med.
PD OCT
PY 2022
VL 52
IS 14
BP 3073
EP 3085
AR PII S0033291720005139
DI 10.1017/S0033291720005139
EA JAN 2021
PG 13
WC Psychology, Clinical; Psychiatry; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA 6M4IT
UT WOS:000785629700001
PM 33443008
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Cheon, SY
   Song, J
AF Cheon, So Yeong
   Song, Juhyun
TI Neuropsychiatric Abnormalities in Metabolic Disturbances: Interplay of
   Adipokines and Neurotransmission
SO MOLECULAR NEUROBIOLOGY
LA English
DT Review; Early Access
DE Metabolic syndrome; Adipokine; Neuropsychiatric disease;
   Brain-metabolism axis
ID PITUITARY-ADRENAL AXIS; MAJOR DEPRESSIVE DISORDER; DIET-INDUCED OBESITY;
   CHOLESTEROL-METABOLISM; PSYCHIATRIC-DISORDERS; INSULIN-RESISTANCE;
   LEPTIN RECEPTOR; NEUROPEPTIDE-Y; NOREPINEPHRINE REUPTAKE; COGNITIVE
   PERFORMANCE
AB Metabolic syndrome, with a high global incidence, is characterized by central obesity, elevated fasting blood glucose, high blood pressure, and abnormal lipid levels, including reduced high-density lipoprotein cholesterol and elevated triglycerides. These metabolic dysfunctions can lead to neurotransmitter alterations and dysregulation of the hypothalamic-pituitary-adrenal axis. These changes, in turn, contribute to mental disorders such as depression and anxiety. Adipokines, secreted from adipose tissue, modulate various metabolic processes, neurotransmission, and immune responses. The interplay between adipokines and neurotransmitters may be a critical component underlying the interaction between metabolic abnormalities and mental disorders. This review aims to discuss the brain-metabolism axis, focusing on altered levels of adipokines and neurotransmitters in metabolic and mental disorders.
C1 [Cheon, So Yeong] Konkuk Univ, Coll Biomed & Hlth Sci, Dept Biotechnol, Chungju, South Korea.
   [Cheon, So Yeong] Konkuk Univ, Res Inst Biomed & Hlth Sci, Chungju, South Korea.
   [Song, Juhyun] Chonnam Natl Univ, Dept Anat, Med Sch, Hwasun 58128, Jeonranamdo, South Korea.
C3 Konkuk University; Konkuk University; Chonnam National University
RP Song, J (corresponding author), Chonnam Natl Univ, Dept Anat, Med Sch, Hwasun 58128, Jeonranamdo, South Korea.
EM juhyunsong@chonnam.ac.kr
FU National Research Foundation of Korea (NRF)
FX The authors thank Biorender for creating the figures.
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NR 238
TC 0
Z9 0
U1 3
U2 3
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0893-7648
EI 1559-1182
J9 MOL NEUROBIOL
JI Mol. Neurobiol.
PD 2025 MAR 5
PY 2025
DI 10.1007/s12035-025-04797-6
EA MAR 2025
PG 19
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA Z2R2D
UT WOS:001437436200001
PM 40042730
DA 2025-06-11
ER

PT J
AU Révész, D
   Milaneschi, Y
   Terpstra, EM
   Penninx, BWJH
AF Revesz, Dora
   Milaneschi, Yuri
   Terpstra, Erik M.
   Penninx, Brenda W. J. H.
TI Baseline biopsychosocial determinants of telomere length and 6-year
   attrition rate
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE Telomeres; Lifestyle; Metabolic syndrome; Inflammation; Autonomic
   nervous system; Cortisol
ID CORONARY-ARTERY-DISEASE; SLEEP DURATION; METABOLIC SYNDROME;
   CIGARETTE-SMOKING; ANXIETY NESDA; LIFE STRESS; DEPRESSION; AGE;
   METAANALYSIS; CELLS
AB Background: Short leukocyte telomere length (TL) and accelerated telomere attrition have been associated with various deleterious health outcomes, although their determinants have not been explored collectively in a large-scale study.
   Material and methods: Leukocyte TL was measured (baseline N = 2936; 6-year follow-up N = 1860) in participants (18-65 years) from the NESDA study. Baseline determinants of TL included so ciodemographics, lifestyle, chronic diseases, psychosocial stressors, and metabolic and physiological stress markers. Multivariate linear regression models were used to examine the associations between these determinants and (1) baseline TL, and (2) 6-year TL change. Multinomial logistic regression analyses were used to examine the predictors of telomere attrition and lengthening, as compared to stable TL.
   Results: Short baseline TL was associated with older age, male sex, non-European ethnicity, cigarette smoking, recent life events, and higher triglycerides, glucose and pre-ejection period (R-2 = 11.3%). The 6 year telomere attrition was inversely associated with baseline TL (R-2 = 51.6%); also older age, long sleep, not having a partner, high childhood trauma index, and gastrointestinal disease were associated with 6 year TL attrition (additional R-2 = 3.7%). Telomere attrition seemed to have slightly more predictors than lengthening.
   Conclusions: Sociodemographic, lifestyle, psychosocial stress and metabolic and physiological stress factors are cross-sectionally linked with TL. Telomere attrition over six years was strongly associated with baseline TL, suggesting an internal homeostatic influence. Modulation of the identified determinants may become target of future studies to promote telomere maintenance and healthy aging. (C) 2016 Elsevier Ltd. All rights reserved.
C1 [Revesz, Dora; Milaneschi, Yuri; Terpstra, Erik M.; Penninx, Brenda W. J. H.] Vrije Univ Amsterdam, Med Ctr, EMGO Inst Hlth & Care Inst, Dept Psychiat, Amsterdam, Netherlands.
C3 Vrije Universiteit Amsterdam
RP Révész, D (corresponding author), POB 74077, NL-1070 BB Amsterdam, Netherlands.
EM D.Revesz@ggzingeest.nl; Y.Milaneschi@ggzingeest.nl;
   E.M.Terpstra@student.vu.nl; B.Penninx@vumc.nl
RI Penninx, Brenda/S-7627-2017
OI Milaneschi, Yuri/0000-0002-3697-6617
FU NWO-VICI [91811602]; Geestkracht program of the Netherlands Organisation
   for Health Research and Development (ZonMW) [10-000-1002]; VU University
   Medical Center; GGZ inGeest; Arkin; Leiden University Medical Center;
   GGZ Rivierduinen; University Medical Center Groningen, Lentis; GGZ
   Friesland; GGZ Drenthe; IQ Healthcare; Netherlands Institute for Health
   Services Research (NIVEL); Netherlands Institute of Mental Health and
   Addiction (Trimbos)
FX The work of BP and DR and telomere length assaying was supported through
   a NWO-VICI grant (number 91811602). The infrastructure for the NESDA
   study (www.nesda.nl) is funded through the Geestkracht program of the
   Netherlands Organisation for Health Research and Development (ZonMW,
   grant number 10-000-1002) and is supported by participating universities
   and mental health care organisations (VU University Medical Center, GGZ
   inGeest, Arkin, Leiden University Medical Center, GGZ Rivierduinen,
   University Medical Center Groningen, Lentis, GGZ Friesland, GGZ Drenthe,
   IQ Healthcare, Netherlands Institute for Health Services Research
   (NIVEL) and Netherlands Institute of Mental Health and Addiction
   (Trimbos)). These funding sources had no involvement in the study
   design, the collection, analysis and interpretation of data; in the
   writing of the report; and in the decision to submit the article for
   publication.
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NR 56
TC 51
Z9 56
U1 1
U2 8
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD MAY
PY 2016
VL 67
BP 153
EP 162
DI 10.1016/j.psyneuen.2016.02.007
PG 10
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA DK0LC
UT WOS:000374603300017
PM 26897704
DA 2025-06-11
ER

PT J
AU Fjermestad, KW
   Huster, R
   Thunberg, C
   Stokke, S
   Gravholt, CH
   Solbakk, AK
AF Fjermestad, Krister W.
   Huster, Rene
   Thunberg, Christina
   Stokke, Simen
   Gravholt, Claus H.
   Solbakk, Anne-Kristin
TI Neuropsychological functions, sleep, and mental health in adults with
   Klinefelter syndrome
SO AMERICAN JOURNAL OF MEDICAL GENETICS PART C-SEMINARS IN MEDICAL GENETICS
LA English
DT Article
DE 47; XXY; executive functions; Klinefelter syndrome; mental health; sleep
ID EXECUTIVE FUNCTIONS; METABOLIC SYNDROME; BOYS; XXY; PREVALENCE;
   ACTIGRAPHY; PHENOTYPES; CHILDHOOD; MORBIDITY; IMPACT
AB A few studies have examined neuropsychological functions, sleep, and mental health combined in Klinefelter syndrome (KS; 47,XXY). We investigated neuropsychological functions with standard tests, sleep with actigraphy, and self-reported mental health in 30 men with KS (Mean age = 36.7 years) compared to 21 controls (Mean age = 36.8 years). Men with KS scored significantly lower on mental speed, attention span, working memory, inhibition, and set-shifting tests, as well as overall IQ (mean effect size difference Cohen's d = 0.79). Men with KS had significantly longer night wakes, with no differences in other sleep variables (mean d = 0.34). Men with KS reported poorer mental health than controls (mean d = 1.16). Regression analyses showed neuropsychological functions explained variance in some sleep domains for men with KS but not for controls. Neuropsychological functions explained variance in some mental health domains for controls. For men with KS, however, verbal IQ was the only significant predictor of mental health. Altogether, men with KS display problems in neuropsychological functions and mental health but do not appear different from controls on most sleep parameters. Our findings indicate that relations between neuropsychological functions, sleep, and mental health differ between men with KS and controls.
C1 [Fjermestad, Krister W.; Huster, Rene; Thunberg, Christina; Solbakk, Anne-Kristin] Univ Oslo, Dept Psychol, Forskningsveien 3a, N-0317 Oslo, Norway.
   [Fjermestad, Krister W.; Stokke, Simen] Frambu Resource Ctr Rare Disorders, Siggerud, Norway.
   [Gravholt, Claus H.] Rhus Univ, Dept Clin Med, Aarhus, Denmark.
   [Solbakk, Anne-Kristin] Oslo Univ Hosp, Dept Neurosurg, Oslo, Norway.
   [Solbakk, Anne-Kristin] Helgeland Hosp, Dept Neuropsychol, Mosjoen, Norway.
   [Solbakk, Anne-Kristin] Univ Oslo, RITMO Ctr Interdisciplinary Studies Rhythm Time &, Oslo, Norway.
C3 University of Oslo; University of Oslo; University of Oslo
RP Fjermestad, KW (corresponding author), Univ Oslo, Dept Psychol, Forskningsveien 3a, N-0317 Oslo, Norway.
EM kristefj@uio.no
RI Gravholt, Claus/Z-1435-2018; Huster, Rene/F-5176-2013
FU National Advisory Unit for Rare Disorders
FX National Advisory Unit for Rare Disorders, Grant/Award Number: n/a
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NR 52
TC 11
Z9 11
U1 0
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1552-4868
EI 1552-4876
J9 AM J MED GENET C
JI Am. J. Med. Genet. C
PD JUN
PY 2020
VL 184
IS 2
SI SI
BP 482
EP 492
DI 10.1002/ajmg.c.31797
EA MAY 2020
PG 11
WC Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Genetics & Heredity
GA MC1OF
UT WOS:000532985900001
PM 32415904
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Lee, H
   Kim, JS
AF Lee, HyunHae
   Kim, Ji-Su
TI Factors Affecting the Health-Related Quality of Life of Cancer Survivors
   According to Metabolic Syndrome
SO CANCER NURSING
LA English
DT Article
DE Cancer; Cancer survivors; Health-related quality of life; Metabolic
   syndrome
ID NUTRITION EXAMINATION SURVEY; CARDIOVASCULAR-DISEASE; NATIONAL-HEALTH;
   LONG-TERM; PREVALENCE; METAANALYSIS; MANAGEMENT; OBESITY; TESTS
AB BackgroundCancer survivors face an increased risk of non-cancer-related deaths, particularly associated with metabolic syndrome. With increased cancer survivors having metabolic syndrome, health-related quality of life beyond cancer diagnosis and treatment has assumed greater importance.ObjectiveThis study evaluated the prevalence rate of metabolic syndrome in cancer survivors. It examined the correlation between health-related quality of life and influencing factors according to the prevalence of metabolic syndrome.MethodsThis is a cross-sectional national study using secondary data from the 2010-2018 Korean National Health and Nutrition Examination Survey by the Korea Disease Control and Prevention Agency. We analyzed a final sample of 1293 cancer survivors using multiple regression.ResultsThe prevalence rate of metabolic syndrome in cancer survivors was measured at 32.1%. Cancer survivors with metabolic syndrome had a lower health-related quality of life than those without it. The difference was statistically significant. Compared with cancer survivors without metabolic syndrome, those with it experienced substantial negative effects from stress, reducing health-related quality of life. Walking and muscle-building workouts had a positive effect on stress and improved quality of life.ConclusionsCancer survivors' metabolic syndrome should be monitored closely. Development of a customized intervention program including stress management and physical activities improves their health-related quality of life.Implications for PracticeStress management and physical activities increase health-related quality of life among cancer survivors with metabolic syndrome; thus, healthcare providers should implement intervention programs that promote exercise engagement and stress management for this population.
C1 [Lee, HyunHae; Kim, Ji-Su] Chung Ang Univ, Dept Nursing, Seoul, South Korea.
   [Kim, Ji-Su] Chung Ang Univ, Dept Nursing, 84 Heukseok Ro, Seoul 156756, South Korea.
C3 Chung Ang University; Chung Ang University
RP Kim, JS (corresponding author), Chung Ang Univ, Dept Nursing, 84 Heukseok Ro, Seoul 156756, South Korea.
EM guspz4hh@cau.ac.kr; jisu80@cau.ac.kr
RI Kim, Kyung/I-5501-2015
OI Kim, Ji-Su/0000-0002-9512-1934; Lee, Hyunhae/0000-0003-0015-044X
CR [Anonymous], 2015, About Metabolic Syndrome
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NR 48
TC 1
Z9 1
U1 0
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0162-220X
EI 1538-9804
J9 CANCER NURS
JI Cancer Nurs.
PD JUL-AUG
PY 2023
VL 46
IS 4
BP 294
EP 302
DI 10.1097/NCC.0000000000001098
PG 9
WC Oncology; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Oncology; Nursing
GA K3FE6
UT WOS:001015321500014
PM 35439201
DA 2025-06-11
ER

PT J
AU Sejbuk, M
   Mironczuk-Chodakowska, I
   Witkowska, AM
AF Sejbuk, Monika
   Mironczuk-Chodakowska, Iwona
   Witkowska, Anna Maria
TI Sleep Quality: A Narrative Review on Nutrition, Stimulants, and Physical
   Activity as Important Factors
SO NUTRIENTS
LA English
DT Review
DE sleep; nutrition; physical activity; stimulants
ID GAMMA-AMINOBUTYRIC-ACID; HIGH-GLYCEMIC-INDEX; VITAMIN-D; INSOMNIA
   SYMPTOMS; CARDIOVASCULAR-DISEASE; IMPROVES SLEEP; OLDER-ADULTS; DIET
   QUALITY; RISK-FACTORS; ALCOHOL-USE
AB Sleep is a cyclically occurring, transient, and functional state that is controlled primarily by neurobiological processes. Sleep disorders and insomnia are increasingly being diagnosed at all ages. These are risk factors for depression, mental disorders, coronary heart disease, metabolic syndrome, and/or high blood pressure. A number of factors can negatively affect sleep quality, including the use of stimulants, stress, anxiety, and the use of electronic devices before sleep. A growing body of evidence suggests that nutrition, physical activity, and sleep hygiene can significantly affect the quality of sleep. The aim of this review was to discuss the factors that can affect sleep quality, such as nutrition, stimulants, and physical activity.
C1 [Sejbuk, Monika; Mironczuk-Chodakowska, Iwona; Witkowska, Anna Maria] Med Univ Bialystok, Dept Food Biotechnol, Szpitalna 37, PL-15295 Bialystok, Poland.
C3 Medical University of Bialystok
RP Sejbuk, M (corresponding author), Med Univ Bialystok, Dept Food Biotechnol, Szpitalna 37, PL-15295 Bialystok, Poland.
EM sejbuk.monika99@gmail.com; iwona.mironczuk-chodakowska@umb.edu.pl;
   anna.witkowska@umb.edu.pl
RI Mironczuk-Chodakowska, Iwona/R-6034-2018; Witkowska, Anna/R-6026-2018
OI Mironczuk-Chodakowska, Iwona/0000-0002-1412-4034; Witkowska,
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TC 126
Z9 131
U1 35
U2 167
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD MAY
PY 2022
VL 14
IS 9
AR 1912
DI 10.3390/nu14091912
PG 26
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nutrition & Dietetics
GA 1F8WM
UT WOS:000795442100001
PM 35565879
OA Green Published, gold
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Goosby, BJ
   Straley, E
   Cheadle, JE
AF Goosby, Bridget J.
   Straley, Elizabeth
   Cheadle, Jacob E.
TI Discrimination, Sleep, and Stress Reactivity: Pathways to African
   American-White Cardiometabolic Risk Inequities
SO POPULATION RESEARCH AND POLICY REVIEW
LA English
DT Article
DE Discrimination; Sleep; Stress; Racial inequities; Cardiometabolic
ID DIURNAL CORTISOL RHYTHMS; EVERYDAY DISCRIMINATION; PERCEIVED
   DISCRIMINATION; ALLOSTATIC LOAD; YOUNG-ADULTS; SOCIOECONOMIC-STATUS;
   INTERNALIZED RACISM; CHRONIC EXPOSURE; BLOOD-PRESSURE; UNITED-STATES
AB This review provides a model explicating two related physiologic and behavioral pathways through which the chronic daily stress of the expectation and experience of discrimination exposure can shape life course cardiometabolic risk trajectories: sleep and stress reactivity. We argue that these two pathways work together jointly to shape African American-White disparities in cardiometabolic morbidities. The body's ongoing anticipation of experiencing racism-related stressors disrupts sleep, a behavior highly responsive to stress reactivity, which is also elevated during stressful conditions. The constant feedback between sleep disruption and the body's stress response can lead to higher allostatic load and disproportionate exposure to stress-related illness among African Americans earlier in their life course.
C1 [Goosby, Bridget J.; Straley, Elizabeth; Cheadle, Jacob E.] Univ Nebraska Lincoln, Dept Sociol, 741 Oldfather Hall, Lincoln, NE 68588 USA.
C3 University of Nebraska System; University of Nebraska Lincoln
RP Goosby, BJ (corresponding author), Univ Nebraska Lincoln, Dept Sociol, 741 Oldfather Hall, Lincoln, NE 68588 USA.
EM bgoosby2@unl.edu
FU University of Nebraska Minority Health Disparities Award; Eunice Kennedy
   Shriver National Institute of Child Health and Human Development [K01 HD
   064537]
FX The authors would like to thank participants of the National Institute
   of Child Health and Human Development and European Research Council
   (United Kingdom) "How Social Environments Get Under the Skin" workgroup
   and Thom McDade for their helpful feedback on earlier drafts of this
   manuscript. This research was funded by a University of Nebraska
   Minority Health Disparities Award and is part of a larger study funded
   by the Eunice Kennedy Shriver National Institute of Child Health and
   Human Development (K01 HD 064537, Bridget Goosby, PI).
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NR 91
TC 51
Z9 60
U1 0
U2 19
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0167-5923
EI 1573-7829
J9 POPUL RES POLICY REV
JI Popul. Res. Policy Rev.
PD OCT
PY 2017
VL 36
IS 5
SI SI
BP 699
EP 716
DI 10.1007/s11113-017-9439-z
PG 18
WC Demography
WE Social Science Citation Index (SSCI)
SC Demography
GA FL4VK
UT WOS:000414229400004
DA 2025-06-11
ER

PT J
AU Dowdy, D
AF Dowdy, Diana
TI Emotional Needs of Teens With Polycystic Ovary Syndrome
SO JOURNAL OF PEDIATRIC NURSING-NURSING CARE OF CHILDREN & FAMILIES
LA English
DT Article
DE Polycystic ovary syndrome; PCOS; Adolescents; Teens; Body image; Self
   image; Mood disorder; Emotinal needs; Quality of life; Depression;
   Anxiety; Obesity; Hyperandrogenism; Hirsutism; Acne; Insulin resistance;
   Metabolic syndrome; Infertility
ID QUALITY-OF-LIFE; BODY-IMAGE; QUESTIONNAIRE PCOSQ; METABOLIC SYNDROME;
   ADOLESCENT GIRLS; WOMEN; OBESITY; HEALTH; WEIGHT; EXPERIENCES
AB Teens with polycystic ovary syndrome have serious health issues that impact them on multiple levels hormonal concerns affecting female health and fertility, disfiguring body changes causing self-image problems, and lifelong health consequences related to metabolic disorders. Health care providers are now beginning to understand underlying pathophysiologic processes and make earlier diagnoses in the 6%-10% of teens with this disorder. However, the profound psychological and social needs are often inadequately recognized by health care providers, causing many teens turn to peers and the Internet for guidance and support. More research is needed to identify and address the emotional aspects of this common disorder in healthcare settings. (C) 2012 Elsevier Inc. All rights reserved.
C1 Univ Alabama, Huntsville, AL 35899 USA.
C3 University of Alabama System; University of Alabama Huntsville
RP Dowdy, D (corresponding author), Univ Alabama, Huntsville, AL 35899 USA.
EM dianadnp@gmail.com
RI Dowdy, Diana/L-1415-2019
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PU ELSEVIER SCIENCE INC
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SN 0882-5963
J9 J PEDIATR NURS
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BP 55
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WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Pediatrics
GA 045OJ
UT WOS:000311705900009
PM 22222107
DA 2025-06-11
ER

PT J
AU Neitzke, U
   Harder, T
   Plagemann, A
AF Neitzke, Uta
   Harder, Thomas
   Plagemann, Andreas
TI Intrauterine Growth Restriction and Developmental Programming of the
   Metabolic Syndrome: A Critical Appraisal
SO MICROCIRCULATION
LA English
DT Review
DE low birthweight; bilateral uterine artery ligation; animal models;
   meta-analysis; small baby syndrome
ID CORONARY-HEART-DISEASE; DEPENDENT DIABETES-MELLITUS; LOW-BIRTH-WEIGHT;
   THRIFTY PHENOTYPE; SUBSEQUENT RISK; INSULIN CONCENTRATIONS;
   CARDIOVASCULAR RISK; GLUCOSE-TOLERANCE; BLOOD-PRESSURE; ISLET FUNCTION
AB P>According to the "small baby syndrome hypothesis," low birthweight and intrauterine growth restriction (IUGR) occurring in westernized countries mainly through altered placental flow, have been linked to increased metabolic syndrome risk in later life. Independency and causal mechanisms of this phenomenological association are a matter of controversy. By means of epidemiological as well as experimental methods, using meta-analyses and different rodent models of pre- and/or neonatal malnutrition and altered placental flow (uterine artery ligation; Lig), we systematically addressed the phenomenon. Our data and systematic literature analysis revealed that neither epidemiological nor experimental evidence seems to exist linking prenatal underfeeding, low birthweight, IUGR, or decreased placental flow in rats (Lig-model) as independent risk factors to increased metabolic syndrome risk in later life. Rather, pre- and/or neonatal overfeeding, elevated birthweight, rapid neonatal weight gain, and especially increased adiposity during critical periods of perinatal life may increase long-term risks. Perinatally acquired microstructural and epigenomic alterations in regulatory systems of metabolism and body weight seem to be critical, leading to a cardiometabolic risk disposition throughout life. While experimental data in Lig-offspring seem to be considerably biased, prenatal stress and postnatal overfeeding/rapid neonatal weight gain might be causally linked to a long-term deleterious outcome in growth restricted newborns. From a clinical point of view, prevention of causes of IUGR, as well as avoidance of perinatal overnourishment, might be prophylactic approaches to avoid perinatal programming of cardiometabolic risks.
C1 [Plagemann, Andreas] Charite, Div Expt Obstet, Campus Virchow Klinikum, Clin Obstet, D-13353 Berlin, Germany.
C3 Berlin Institute of Health; Free University of Berlin; Humboldt
   University of Berlin; Charite Universitatsmedizin Berlin
RP Plagemann, A (corresponding author), Charite, Div Expt Obstet, Campus Virchow Klinikum, Clin Obstet, Augustenburger Pl 1, D-13353 Berlin, Germany.
EM andreas.plagemann@charite.de
RI Plagemann, Andreas/F-7337-2012
FU German Research Foundation (DFG) [PL 241/3, 241/4, 241/5]
FX This work was supported by the German Research Foundation (DFG; PL
   241/3, 241/4, 241/5).
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NR 53
TC 59
Z9 68
U1 0
U2 15
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1073-9688
EI 1549-8719
J9 MICROCIRCULATION
JI Microcirculation
PD MAY
PY 2011
VL 18
IS 4
BP 304
EP 311
DI 10.1111/j.1549-8719.2011.00089.x
PG 8
WC Hematology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Hematology; Cardiovascular System & Cardiology
GA 754ZQ
UT WOS:000289896800007
PM 21418379
DA 2025-06-11
ER

PT J
AU Yun, J
   Lee, Y
AF Yun, Jungmi
   Lee, Yunji
TI Comparison of Sleep Disturbance, Physical Activity, and Health-Related
   Quality of Life According to Depressive Symptoms in Patients with
   Metabolic Syndrome: A Secondary Analysis from the Korea National Health
   and Nutrition Examination Survey Using a Propensity Score Matching
   Analysis
SO HEALTHCARE
LA English
DT Article
DE sleep; exercise; quality of life; depressive disorder; metabolic
   syndrome
ID ADULTS; DURATION; METAANALYSIS; ASSOCIATION; MANAGEMENT; WALKING; WOMEN
AB Metabolic syndrome has become a global epidemic, and the age of its onset is decreasing. However, its prevalence can be reduced by lifestyle modifications. This study examined the differences in sleep disturbance, physical activity, and health-related quality of life associated with depressive symptoms in patients with metabolic syndrome aged & GE; 40 years. This cross-sectional secondary analysis of data from the 2016 and 2018 Korean National Health and Nutrition Examination Surveys. Of 1404 patients with metabolic syndrome aged & GE; 40 years, depressed and non-depressed patients (103 vs. 103) were matched 1:1 on demographic characteristics using propensity score matching. The outcome variables were then compared between the two groups. We investigated health status, including metabolic syndrome indices, health behaviors, such as sleep disturbances and physical activity, and health-related quality of life. After propensity score matching, health-related quality of life was the only variable that differed significantly between the groups; it was significantly lower in patients with depression (0.77) than in those without depression (0.88) (p = 0.001). Our results suggest that depression with metabolic syndrome is likely to cause a decrease in patients' quality of life; therefore, development of management systems and programs for early intervention to tackle at-risk groups is necessary.
C1 [Yun, Jungmi; Lee, Yunji] Pusan Natl Univ, Coll Nursing, Yangsan 50612, South Korea.
   [Yun, Jungmi] Pusan Natl Univ, Res Inst Nursing Sci, Yangsan 50612, South Korea.
C3 Pusan National University; Pusan National University
RP Lee, Y (corresponding author), Pusan Natl Univ, Coll Nursing, Yangsan 50612, South Korea.
EM jmyun@pusan.ac.kr; yjlee22@pusan.ac.kr
FU Pusan National University
FX This work was supported by a 2-Year Research Grant of Pusan National
   University.
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NR 53
TC 0
Z9 0
U1 0
U2 6
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2227-9032
J9 HEALTHCARE-BASEL
JI Healthcare
PD JUN
PY 2023
VL 11
IS 12
AR 1802
DI 10.3390/healthcare11121802
PG 14
WC Health Care Sciences & Services; Health Policy & Services
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services
GA K5WX3
UT WOS:001017153400001
PM 37372918
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Després, JP
AF Despres, Jean-Pierre
TI Abdominal Obesity and Cardiovascular Disease: Is Inflammation the
   Missing Link?
SO CANADIAN JOURNAL OF CARDIOLOGY
LA English
DT Review
ID C-REACTIVE PROTEIN; CORONARY-HEART-DISEASE; ADIPOSE-TISSUE DISTRIBUTION;
   14 RANDOMIZED-TRIALS; METABOLIC SYNDROME; MYOCARDIAL-INFARCTION;
   WEIGHT-LOSS; RISK-FACTORS; CARDIOMETABOLIC RISK; HYPERTRIGLYCERIDEMIC
   WAIST
AB It is well established that cardiovascular disease has an inflammatory component. The present narrative review explores the role of adipose tissue distribution, morphology, and function as potential mediators of the link between inflammation and cardiovascular disease. Evidence that abdominal obesity is a key driving force behind a constellation of athero-thrombotic inflammatory abnormalities linked to insulin resistance and often referred to as the metabolic syndrome is also reviewed. It is also proposed that the amount of visceral adipose tissue and the liver fat content are important factors responsible for the link between abdominal obesity and features of the metabolic syndrome. It is suggested that the inflammatory profile associated with excess visceral adipose tissue/liver fat may be a consequence of the relative inability of subcutaneous adipose tissue to expand through hyperplasia and to act as a protective metabolic sink storing the chronic energy surplus resulting from a positive energy balance (overnutrition or lack of physical activity or both). In this model, the inflammatory profile often observed among sedentary over-weight/obese individuals with an excess of visceral adipose tissue/ liver fat may be a consequence of a more primary defect in subcutaneous adipose tissue. On that basis, it is proposed that therapeutic strategies relieving the stress for storage of a chronic energy surplus in the subcutaneous adipose tissue (reduced caloric intake, increase in energy expenditure, pharmacotherapy) should induce a substantial loss of visceral adipose tissue and of ectopic fat depots such as the liver, thereby substantially reducing inflammation.
C1 [Despres, Jean-Pierre] Inst Univ Cardiol & Pneumol Quebec, Ctr Rech, Quebec City, PQ G1V 4G5, Canada.
   [Despres, Jean-Pierre] Univ Laval, Fac Med, Dept Kinesiol, Quebec City, PQ G1K 7P4, Canada.
C3 Laval University; Laval University Hospital; Laval University
RP Després, JP (corresponding author), Inst Univ Cardiol & Pneumol Quebec, Ctr Rech, 4th Floor,2725 Chemin, Quebec City, PQ G1V 4G5, Canada.
EM jean-pierre.despres@criucpq.ulaval.ca
FU Canadian Institutes of Health Research; Heart and Stroke Foundation of
   Canada; Canadian Diabetes Association; Fonds de recherche du
   Quebec-Sante; Foundation of the Institut universitaire de cardiologie et
   de pneumologie de Quebec; Eli Lilly Canada; Sanofi; Abbott; AstraZeneca;
   GlaxoSmithKline; Pfizer Canada Inc; Merck; Novartis; Theratechnologies;
   Torrent Pharma Ltd.
FX The work of the author has been funded by the Canadian Institutes of
   Health Research, the Heart and Stroke Foundation of Canada, the Canadian
   Diabetes Association, the Fonds de recherche du Quebec-Sante, and the
   Foundation of the Institut universitaire de cardiologie et de
   pneumologie de Quebec. Jean-Pierre Despres has also conducted clinical
   studies funded by Eli Lilly Canada and by Sanofi. The author is the
   Scientific Director of the International Chair on Cardiometabolic Risk
   which is based at Universite Laval. The author has received honoraria as
   a speaker or consulting fees from Abbott, AstraZeneca, GlaxoSmithKline,
   Pfizer Canada Inc, Merck, Sanofi, Novartis, Theratechnologies, and
   Torrent Pharma Ltd.
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NR 107
TC 92
Z9 105
U1 2
U2 22
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0828-282X
EI 1916-7075
J9 CAN J CARDIOL
JI Can. J. Cardiol.
PD NOV-DEC
PY 2012
VL 28
IS 6
BP 642
EP 652
DI 10.1016/j.cjca.2012.06.004
PG 11
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 053GW
UT WOS:000312260400008
PM 22889821
DA 2025-06-11
ER

PT J
AU Zahid, MA
   Abdelsalam, SS
   Raïq, H
   Abunada, HH
   Parray, A
   Agouni, A
AF Zahid, Muhammad Ammar
   Abdelsalam, Shahenda Salah
   Raiq, Hicham
   Abunada, Hanan H.
   Parray, Aijaz
   Agouni, Abdelali
TI Association of plasma levels of Sestrin2 with adiposity and metabolic
   function indices in healthy and diabetic subjects from Qatar Biobank
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Article
DE adiposity; biomarker; diabetes mellitus; metabolic syndrome; Sestrin2
ID INSULIN-RESISTANCE; HOMEOSTASIS
AB Background: Despite the accumulating evidence from cellular and animal studies, the role of circulating Sestrin2, a stress-inducible antioxidant protein, in human cardiometabolic health remains largely unexplored. Hence, the current study aimed to investigate the association between circulating Sestrin2 and cardiometabolic risk factors in healthy and diabetic individuals. Methods: This cross-sectional study leveraging data and plasma samples from the Qatar Biobank investigated the relationship between plasma Sestrin2 levels and various cardiometabolic indices in 326 healthy and 518 diabetic subjects. Results: The study found that Sestrin2 levels were significantly lower in diabetic individuals compared to healthy controls (5.49 ng/mL vs 8.25 ng/mL, p < 0.001). In the healthy cohort, higher Sestrin2 levels were associated with a favorable metabolic profile, indicated by lower odd ratios (OR) of high glycated hemoglobin (OR: 0.33), Homeostatic Model Assessment for Insulin Resistance score (OR: 0.58), visceral adiposity index (OR: 0.46), lipid accumulation product (OR: 0.49), atherogenic index of plasma (OR: 0.42) and metabolic syndrome (OR: 0.23). Conversely, in the diabetic cohort, higher Sestrin2 levels were paradoxically linked to increased triglycerides (OR: 1.57), the product of triglyceride glucose and waist circumference (OR: 1.8), body fat (OR: 1.72), waist circumference (OR: 1.82), waist-to-hip ratio (OR: 1.96) and metabolic syndrome (OR: 1.48). Conclusions: These findings suggest that Sestrin2 may play a complex and context-dependent role in metabolic regulation, potentially serving as a protective factor in healthy individuals but contributing to metabolic dysfunction in the context of established diabetes. Further research is needed to elucidate the underlying mechanisms and implications for targeted interventions.
C1 [Zahid, Muhammad Ammar; Abdelsalam, Shahenda Salah; Agouni, Abdelali] Qatar Univ, QU Hlth, Coll Pharm, Dept Pharmaceut Sci, Doha, Qatar.
   [Raiq, Hicham] Qatar Univ, Coll Arts & Sci, Dept Social Sci, Doha, Qatar.
   [Abunada, Hanan H.] Qatar Univ, QU Hlth, Med & Hlth Sci, Doha, Qatar.
   [Parray, Aijaz] Hamad Med Corp, Neurosci Inst, Acad Hlth Syst, Doha, Qatar.
C3 Qatar University; Qatar University; Qatar University; Hamad Medical
   Corporation
RP Agouni, A (corresponding author), Qatar Univ, QU Hlth, Coll Pharm, Dept Pharmaceut Sci, Doha, Qatar.
EM aagouni@qu.edu.qa
FU Qatar Biobank [QF-QBB-RES-ACC-00049-0173]; Qatar National Research Fund
   (Qatar Research Development and Innovation Council)
   [NPRP14S-0406-210150]; Qatar University [QUST-1-CPH-2025-247]; Office of
   Graduate Studies (Qatar University); Qatar National Library
FX The author(s) declare that financial support was received for the
   research and/or publication of this article. This work was made possible
   with the support of Qatar Biobank (protocol #
   QF-QBB-RES-ACC-00049-0173). The study was funded by the Qatar National
   Research Fund (Qatar Research Development and Innovation Council) (grant
   No. NPRP14S-0406-210150) and Qatar University grant No.
   QUST-1-CPH-2025-247. MZ and SA are supported by Ph.D. graduate
   assistantships from the Office of Graduate Studies (Qatar University).
   The statements made herein are solely the responsibility of the authors.
   Open Access funding provided by the Qatar National Library.
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NR 32
TC 0
Z9 0
U1 0
U2 0
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD MAY 13
PY 2025
VL 16
AR 1518388
DI 10.3389/fendo.2025.1518388
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 2ZR0T
UT WOS:001495137400001
PM 40433409
OA gold
DA 2025-06-11
ER

PT J
AU Gambaro, A
   Lombardi, G
   Caletti, C
   Ribichini, FL
   Ferraro, PM
   Gambaro, G
AF Gambaro, Alessia
   Lombardi, Gianmarco
   Caletti, Chiara
   Ribichini, Flavio Luciano
   Ferraro, Pietro Manuel
   Gambaro, Giovanni
TI Nephrolithiasis: A Red Flag for Cardiovascular Risk
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Review
DE calcification paradox; cardiovascular risk; ectopic calcification;
   hypertension; metabolic syndrome; nephrolithiasis; osteoporosis
ID BONE-MINERAL DENSITY; ESTROGEN-RECEPTOR-ALPHA; URINARY CALCIUM
   EXCRETION; URIC-ACID NEPHROLITHIASIS; TRIMETHYLAMINE N-OXIDE;
   AORTIC-VALVE SCLEROSIS; CORONARY-HEART-DISEASE; QUALITY-OF-LIFE;
   METABOLIC SYNDROME; KIDNEY-STONES
AB Epidemiological evidence shows that nephrolithiasis is associated with cardiovascular (CV) morbidities. The association between nephrolithiasis and CV disease is not surprising because both diseases share conditions that facilitate their development. Metabolic conditions, encompassed in the definition of metabolic syndrome (MS), and habits that promote nephrolithiasis by altering urine composition also promote clinical manifestations of CV disease. By inducing oxidative stress, these conditions cause endothelial dysfunction and increased arterial stiffness, which are both well-known predictors of CV disease. Furthermore, the subtle systemic metabolic acidosis observed in stone formers with CV disease may have a pathogenic role by increasing bone turnover and leading to reduced mineral content and osteoporosis/osteopenia. Heart valves and/or coronary artery and aortic calcifications are frequently associated with reduced mineral density. This is known as the 'calcification paradox' in osteoporosis and has also been observed in subjects with calcium nephrolithiasis. Evidence supports the hypothesis that osteoporosis/osteopenia is an independent risk factor for the development of CV calcifications. In the long term, episodes of renal stones may occur from the onset of metabolic derangements/MS to arterial stiffness/atherosclerosis and CV morbidities. These episodes should be considered a warning sign of an ongoing and silent atherosclerotic process. The evaluation of cardiometabolic risk factors and MS components should be routine in the assessment of renal stone formers. This would allow for treatment and prevention of the development of CV complications, which are much more severe for the patient and for public health.
C1 [Gambaro, Alessia; Ribichini, Flavio Luciano] Univ Verona, Dept Med, Div Cardiol, I-37126 Verona, Italy.
   [Lombardi, Gianmarco; Caletti, Chiara; Gambaro, Giovanni] Univ Verona, Dept Med, Div Nephrol, I-37126 Verona, Italy.
   [Ferraro, Pietro Manuel] Fdn Policlin Univ A Gemelli IRCCS, UOS Terapia Conservat Malattia Renale Cron, I-00168 Rome, Italy.
C3 University of Verona; University of Verona; Catholic University of the
   Sacred Heart; IRCCS Policlinico Gemelli
RP Gambaro, G (corresponding author), Univ Verona, Dept Med, Div Nephrol, I-37126 Verona, Italy.
EM giovanni.gambaro@univr.it
RI GAMBARO, GIOVANNI/AAC-2173-2019; lombardi, gianmarco/KSL-9228-2024;
   /H-1517-2012; Lombardi, Gianmarco/W-3595-2018; Gambaro,
   Alessia/AFR-0432-2022
OI Lombardi, Gianmarco/0000-0003-2298-1420; Gambaro,
   Giovanni/0000-0001-5733-2370; , Chiara Caletti/0000-0001-5309-6251;
   Gambaro, Alessia/0000-0001-8341-1427; RIBICHINI, Flavio
   Luciano/0000-0002-6662-0304
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NR 127
TC 8
Z9 9
U1 0
U2 6
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD OCT
PY 2022
VL 11
IS 19
AR 5512
DI 10.3390/jcm11195512
PG 12
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 5H9EE
UT WOS:000867973100001
PM 36233380
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Henriksen, RE
   Nilsen, RM
   Strandberg, RB
AF Henriksen, Roger Ekeberg
   Nilsen, Roy M.
   Strandberg, Ragnhild Bjarkoy
TI Loneliness as a risk factor for metabolic syndrome: results from the
   HUNT study
SO JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH
LA English
DT Article
DE depression; obesity; psychosocial factors; social epidemiology; stress
ID DEPRESSIVE SYMPTOMS; SOCIAL-ISOLATION; CHRONIC STRESS; ASSOCIATION;
   EVOLUTIONARY; METAANALYSIS; SUPPORT; SCALE; FOOD
AB Objective Metabolic syndrome (MetS) includes hyperglycaemia, hypertension, central adiposity, elevated triglyceride levels and low levels of high-density lipoprotein cholesterol. All factors are identified as risk factors for cardiovascular disease and mortality. This longitudinal study examined whether loneliness, which has been shown to predict a range of negative health outcomes, increases the risk for MetS. Methods We used data from 'the Nord-Trondelag Health Study' (HUNT) which is a large longitudinal health study based on a Mid-Norway county population (n=26 990). Self-reports, physical examinations and blood samples were analysed to evaluate the associations between loneliness and incidents of MetS after 10 years (follow-up survey conducted during 2006-2008). We also investigated the role of depression as a potential mediating factor. Results Individuals who reported higher levels of loneliness had a higher odds for MetS (adjusted OR 1.09 (95% CI 1.02 to 1.16); p=0.007). This effect was mediated through depression. Conclusions Findings suggest that loneliness may be an important factor that increases the risk for MetS. The effect of loneliness on MetS is mediated through depressive symptoms. Reducing loneliness may help prevent the incidence of MetS and related diseases.
C1 [Henriksen, Roger Ekeberg; Strandberg, Ragnhild Bjarkoy] Western Norway Univ Appl Sci, Fac Hlth & Social Sci, Dept Hlth & Caring Sci, N-5020 Bergen, Norway.
   [Nilsen, Roy M.] Western Norway Univ Appl Sci, Fac Hlth & Social Sci, Dept Hlth & Functioning, Bergen, Norway.
C3 Western Norway University of Applied Sciences; Western Norway University
   of Applied Sciences
RP Henriksen, RE (corresponding author), Western Norway Univ Appl Sci, Fac Hlth & Social Sci, Dept Hlth & Caring Sci, N-5020 Bergen, Norway.
EM reh@hvl.no
OI Nilsen, Roy Miodini/0000-0002-6340-4593; Henriksen, Roger
   Ekeberg/0000-0001-6507-5415
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NR 43
TC 25
Z9 30
U1 0
U2 13
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 0143-005X
EI 1470-2738
J9 J EPIDEMIOL COMMUN H
JI J. Epidemiol. Community Health
PD OCT
PY 2019
VL 73
IS 10
BP 941
EP 946
DI 10.1136/jech-2019-212335
PG 6
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA JA0YP
UT WOS:000487542000008
PM 31266768
DA 2025-06-11
ER

PT J
AU Gur, M
   Yildiz, A
   Demirbag, R
   Yilmaz, R
   Aslan, M
   Ozdogru, I
   Erel, O
AF Gur, Mustafa
   Yildiz, Ali
   Demirbag, Recep
   Yilmaz, Remzi
   Aslan, Mehmet
   Ozdogru, Ibrahim
   Erel, Ozcan
TI Paraoxonase and arylesterase activities in patients with cardiac
   syndrome X, and their relationship with oxidative stress markers
SO CORONARY ARTERY DISEASE
LA English
DT Article
DE antioxidant; arylesterase; cardiac syndrome X; high-density lipoprotein;
   lipid hydroperoxide; paraoxonase
ID CORONARY-ARTERY-DISEASE; HUMAN-SERUM PARAOXONASE;
   LOW-DENSITY-LIPOPROTEIN; LIPID HYDROPEROXIDES; AUTOMATED-METHOD;
   ANGINA-PECTORIS; HEART-DISEASE; ATHEROSCLEROSIS; PROTEIN; DAMAGE
AB Objectives Paraoxonase-1 is a high-density lipoprotein-associated enzyme with three activities, which are paraoxonase, arylesterase and dyazoxonase. Paraoxonase-1 was shown to decrease in patients with cardiovascular diseases. We aimed to examine serum paraoxonase and arylesterase activities, and their relation with oxidative stress markers such as lipid hydroperoxide and total antioxidant status in patients with cardiac syndrome X.
   Methods Forty-one consecutive patients with cardiac syndrome X (CSX group), 33 consecutive patients without cardiac syndrome X (non-cardiac syndrome X group) and 20 healthy volunteers as control group were taken into the study. Serum paraoxonase and arylesterase activities were measured spectrophotometrically. Lipid hydroperoxide levels were measured by ferrous oxidation with xylenol orange assay. Total antioxidant status was determined using an automated measurement method.
   Results Basal paraoxonase, salt-stimulated paraoxonase and arylesterase activities were significantly lower in patients with cardiac syndrome X than those of the non-cardiac syndrome X and control groups (P < 0.001, for both). Moreover, lipid hydroperoxide was found at high level, and total antioxidant status was found at low level in patients with cardiac syndrome X than control and non-cardiac syndrome X groups (P < 0.001, for all).
   In patients with cardiac syndrome X, in multiple linear regression analysis, both paraoxonase and arylesterase activities were independently correlated with lipid hydroperoxide levels (P=0.001, P=0.003, respectively), and also arylesterase activity was independently correlated with magnitude of ST depression (P=0.002).
   Conclusion Reduced paraoxonase and arylesterase activities and total antioxidant status levels and enhanced lipid hydroperoxide levels in patients with cardiac syndrome X might indicate increased oxidative stress that can play a role in pathogenesis of cardiac syndrome X. (c) 2007 Lippincott Williams & Wilkins.
C1 Harran Univ, Dept Cardiol, Fac Med, Yenisehir, Sanliufa, Turkey.
   Harran Univ, Dept Internal Med, Fac Med, Yenisehir, Sanliufa, Turkey.
   Harran Univ, Dept Clin Biochem, Fac Med, Yenisehir, Sanliufa, Turkey.
   Erciyes Univ, Fac Med, Dept Cardiol, Kayseri, Turkey.
C3 Harran University; Harran University; Harran University; Erciyes
   University
RP Gur, M (corresponding author), Harran Univ, Dept Cardiol, Fac Med, PK 112, Yenisehir, Sanliufa, Turkey.
EM drmugur@yahoo.com
RI Demirbag, Recep/Z-2369-2019; EREL, Ozcan/U-1008-2019
OI Demirbag, Recep/0000-0001-7831-2715
CR ASLAN M, 2006, ATHEROSCLEROSIS 0506
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NR 44
TC 33
Z9 33
U1 0
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0954-6928
EI 1473-5830
J9 CORONARY ARTERY DIS
JI Coronary Artery Dis.
PD MAR
PY 2007
VL 18
IS 2
BP 89
EP 95
DI 10.1097/MCA.0b013e32801104e8
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 145ER
UT WOS:000244848600003
PM 17301599
DA 2025-06-11
ER

PT J
AU James, AM
   Collins, Y
   Logan, A
   Murphy, MP
AF James, Andrew M.
   Collins, Yvonne
   Logan, Angela
   Murphy, Michael P.
TI Mitochondrial oxidative stress and the metabolic syndrome
SO TRENDS IN ENDOCRINOLOGY AND METABOLISM
LA English
DT Review
ID INSULIN-RESISTANCE; SUPEROXIDE-DISMUTASE; ANTIOXIDANT DEFENSE;
   SIGNAL-TRANSDUCTION; SKELETAL-MUSCLE; MECHANISMS; CELLS; H2O2;
   ACONITASE; PROTEINS
AB The current epidemic of the metabolic syndrome in the developed world is largely due to overnutrition and lack of physical activity. However, the underlying causes by which chronic overnutrition interacts with genotype and physical inactivity to generate the metabolic syndrome phenotype are complex, and include multiple metabolic and physiological alterations. Mitochondrial oxidative stress has been suggested to contribute to the metabolic syndrome, but the mechanisms and significance are unclear. Here we review how disruption of mitochondrial metabolism and increased oxidative stress may occur during overnutrition coupled with limited physical activity. From this we suggest a unifying hypothesis to integrate what is known about mitochondrial involvement in the metabolic syndrome that points to testable hypotheses and novel therapeutic approaches.
C1 [James, Andrew M.; Collins, Yvonne; Logan, Angela; Murphy, Michael P.] MRC, Mitochondrial Biol Unit, Cambridge CB2 0XY, England.
RP Murphy, MP (corresponding author), MRC, Mitochondrial Biol Unit, Wellcome Trust MRC Bldg,Hills Rd, Cambridge CB2 0XY, England.
EM mpm@mrc-mbu.cam.ac.uk
RI Murphy, Michael/C-2120-2009; James, Andrew/A-2639-2015
OI Murphy, Michael/0000-0003-1115-9618; Logan, Angela/0000-0002-7141-9883;
   James, Andrew/0000-0002-0515-9649
FU MRC (UK); Biotechnology and Biological Sciences Research Council
   (BBSRC); MRC [MC_U105663142] Funding Source: UKRI
FX Work in the authors' laboratories is funded by the MRC (UK) and the
   Biotechnology and Biological Sciences Research Council (BBSRC). We
   sincerely apologise to colleagues whose work has been omitted from this
   review as due to space limitations, only a few illustrative examples
   could be discussed.
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NR 60
TC 119
Z9 129
U1 1
U2 32
PU ELSEVIER SCIENCE LONDON
PI LONDON
PA 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND
SN 1043-2760
EI 1879-3061
J9 TRENDS ENDOCRIN MET
JI Trends Endocrinol. Metab.
PD SEP
PY 2012
VL 23
IS 9
SI SI
BP 429
EP 434
DI 10.1016/j.tem.2012.06.008
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 006WQ
UT WOS:000308850900003
PM 22831852
DA 2025-06-11
ER

PT J
AU Da Costa, SKS
   Almeida, JA
   Pires, LV
   Brandao-Lima, PN
   Rogero, MM
   Mendes-Netto, RS
AF Santos da Costa, Sheila Kely
   Almeida, Jamylle Araujo
   Pires, Liliane Viana
   Brandao-Lima, Paula Nascimento
   Rogero, Marcelo Macedo
   Mendes-Netto, Raquel Simoes
TI Relationship Between the Single Nucleotide Polymorphism rs11558471 in
   the SLC30A8/ZnT8 Gene and Cardiometabolic Markers in Postmenopausal
   Women
SO BIOLOGICAL TRACE ELEMENT RESEARCH
LA English
DT Article; Early Access
DE Single nucleotide polymorphism; Metabolic syndrome; Menopause;
   Cardiometabolic risk; Zinc transporter 8
ID GLUCOSE-HOMEOSTASIS; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   DIABETES-MELLITUS; TYPE-2; ASSOCIATION; PATHOPHYSIOLOGY; MENOPAUSE;
   GLOBORISK; STRESS
AB Postmenopausal women have more risk factors for metabolic syndrome, and genetic alterations in SLC30A8 (zinc transporter 8 [ZnT8]) are directly related to these factors. Our aim was to assess the relationship of the single nucleotide polymorphism (SNP) rs11558471 in the SLC30A8/ZnT8 gene with cardiometabolic markers in postmenopausal women. This cross-sectional study included 53 postmenopausal women divided into two groups according to the SNP genotype (AG + GG [n = 25] and AA [n = 28]). Anthropometric, dietary, and biochemical (glycemic, lipidic, hepatic, renal, and hormonal markers) variables were evaluated and compared between groups. No differences in glycemic, hepatic, renal, and hormonal markers were found between groups. However, the group with the polymorphic allele (AG + GG) had a better lipid profile than non-carriers (total cholesterol, p = 0.041; low-density lipoprotein cholesterol [LDL-c], p = 0.035; non-high-density lipoprotein cholesterol [non-HDL-c], p = 0.043). Logistic regression showed that the group with polymorphic allele had lower chances of increasing levels of LDL-c (odds ratio [OR] = 0.225, p = 0.012) and non-HDL-c (OR = 0.316, p = 0.045). After adjusting for age, body mass index, physical activity, and use of diabetes and dyslipidemia drugs, only LDL-c remained associated (OR = 0.218; p = 0.017). The variant allele of SNP rs11558471 in the SLC30A8 gene was associated with better LDL-c levels, which helps reduce the risks for cardiovascular diseases in postmenopausal women.
C1 [Santos da Costa, Sheila Kely; Pires, Liliane Viana; Mendes-Netto, Raquel Simoes] Univ Fed Sergipe, Ctr Biol & Hlth Sci, Dept Nutr, BR-49100000 Sao Cristovao, Sergipe, Brazil.
   [Almeida, Jamylle Araujo; Pires, Liliane Viana; Mendes-Netto, Raquel Simoes] Univ Fed Sergipe, Ctr Biol & Hlth Sci, Dept Nutr, Nutr Sci Postgrad Program, Av Marechal Rondon S-N, BR-49100000 Sao Cristovao, Sergipe, Brazil.
   [Brandao-Lima, Paula Nascimento; Rogero, Marcelo Macedo] Univ Sao Paulo, Fac Publ Hlth, Nutr Publ Hlth Postgrad Program, BR-01246904 Sao Paulo, SP, Brazil.
C3 Universidade Federal de Sergipe; Universidade Federal de Sergipe;
   Universidade de Sao Paulo
RP Pires, LV (corresponding author), Univ Fed Sergipe, Ctr Biol & Hlth Sci, Dept Nutr, BR-49100000 Sao Cristovao, Sergipe, Brazil.; Pires, LV (corresponding author), Univ Fed Sergipe, Ctr Biol & Hlth Sci, Dept Nutr, Nutr Sci Postgrad Program, Av Marechal Rondon S-N, BR-49100000 Sao Cristovao, Sergipe, Brazil.
EM lvianapires@academico.ufs.br
RI Rogero, Marcelo/F-6246-2012; Mendes-Netto, Raquel/W-8120-2019
OI Brandao Lima, Paula/0000-0002-0949-361X; PIRES,
   LILIANE/0000-0003-1710-0836; Mendes-Netto, Raquel
   Simoes/0000-0001-8238-8958; Macedo Rogero, Marcelo/0000-0003-0517-1645
FU National Council for Scientific and Technological Development (CNPq)
   [455117/2014-4, 14/2014]; Research and Technological Innovation Support
   Foundation of the State of Sergipe [PROMOB-88881 157882/2017-01,
   PROEF-88887.157406/2017-00]; Coordination for the Improvement of Higher
   Education Personnel (CAPES) [001]
FX This work was supported by the National Council for Scientific and
   Technological Development (CNPq) (Universal Notice - Called MCTIC/CNPq N
   degrees 14/2014, process 455117/2014-4), the Research and Technological
   Innovation Support Foundation of the State of Sergipe (FAPITEC/SE:
   PROMOB-88881 157882/2017-01 and PROEF-88887.157406/2017-00), and the
   Coordination for the Improvement of Higher Education Personnel
   (CAPES-Finance Code 001).
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NR 42
TC 1
Z9 1
U1 0
U2 3
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0163-4984
EI 1559-0720
J9 BIOL TRACE ELEM RES
JI Biol. Trace Elem. Res.
PD 2022 JUL 6
PY 2022
DI 10.1007/s12011-022-03337-w
EA JUL 2022
PG 8
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 2R8QT
UT WOS:000821371000001
PM 35793043
DA 2025-06-11
ER

PT J
AU Giannousi, Z
   Gioulbasanis, I
   Pallis, AG
   Xyrafas, A
   Dalliani, D
   Kalbakis, K
   Papadopoulos, V
   Mavroudis, D
   Georgoulias, V
   Papandreou, CN
AF Giannousi, Zoe
   Gioulbasanis, Ioannis
   Pallis, Athanasios G.
   Xyrafas, Alexandros
   Dalliani, Danai
   Kalbakis, Kostas
   Papadopoulos, Vassilis
   Mavroudis, Dimitris
   Georgoulias, Vassilis
   Papandreou, Christos N.
TI Nutritional status, acute phase response and depression in metastatic
   lung cancer patients: correlations and association prognosis
SO SUPPORTIVE CARE IN CANCER
LA English
DT Article
DE Lung cancer; MNA; Depression; Acute phase response
ID QUALITY-OF-LIFE; WEIGHT-LOSS; HOSPITAL ANXIETY; CACHEXIA; INFLAMMATION;
   CHEMOTHERAPY; SURVIVAL; SYMPTOM; SCORE; INSTRUMENTS
AB Cancer cachexia is a metabolic syndrome related with poor outcome. Cytokines play a key role in the pathophysiology of that syndrome. The aim of this study was to investigate the potential correlations between nutritional status, systemic inflammation, and psychological distress in cancer patients. The prognostic significance of the recorded parameters was also assessed.
   Patients with metastatic lung cancer were eligible. Mini Nutritional Assessment (MNA) was used for the evaluation of nutritional status, Glasgow Prognostic Score (GPS) for the estimation of systemic inflammation, and Hospital Anxiety and Depression Scale (HADS) for psychological assessment.
   Totally, 122 patients were enrolled (71.3% with NSCLC and 28.7% with SCLC). The following correlations were observed: MNA and GPS (r = 0.289, p = 0.001), MNA and HADS (depression scale) (r = 0.275, p = 0.002), GPS and HADS (depression scale) (r = 0.256, p = 0.004), and GPS and HADS (anxiety scale) (r = 0.194, p = 0.033). In univariate analysis, GPS (p = 0.002) and MNA (p = 0.010) emerged as significant predictors of survival. In multivariate analysis, both MNA (p = 0.032) and GPS (p = 0.020) retained their importance.
   This study highlights the associations between nutritional status, systemic inflammation, and psychological distress, supporting their common underlying pathophysiological mechanisms and further suggesting the necessity of a holistic anti-cachectic approach.
C1 [Giannousi, Zoe; Pallis, Athanasios G.; Xyrafas, Alexandros; Kalbakis, Kostas; Mavroudis, Dimitris; Georgoulias, Vassilis] Univ Gen Hosp Heraklion, Dept Med Oncol, Iraklion 71110, Crete, Greece.
   [Gioulbasanis, Ioannis; Dalliani, Danai; Papadopoulos, Vassilis; Papandreou, Christos N.] Univ Hosp Larissa, Dept Med Oncol, Larisa, Thessaly, Greece.
C3 University Hospital of Heraklion; General University Hospital of Larissa
RP Giannousi, Z (corresponding author), Univ Gen Hosp Heraklion, Dept Med Oncol, Iraklion 71110, Crete, Greece.
EM zgiannousi@gmail.com; georgsec@med.uoc.gr
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NR 41
TC 50
Z9 55
U1 0
U2 10
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0941-4355
EI 1433-7339
J9 SUPPORT CARE CANCER
JI Support. Care Cancer
PD AUG
PY 2012
VL 20
IS 8
BP 1823
EP 1829
DI 10.1007/s00520-011-1282-x
PG 7
WC Oncology; Health Care Sciences & Services; Rehabilitation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Health Care Sciences & Services; Rehabilitation
GA 970LG
UT WOS:000306129600028
PM 21959842
DA 2025-06-11
ER

PT J
AU Sanchez, M
   Gonzalez-Burgos, E
   Iglesias, I
   Lozano, R
   Gomez-Serranillos, MP
AF Sanchez, Marta
   Gonzalez-Burgos, Elena
   Iglesias, Irene
   Lozano, Rafael
   Gomez-Serranillos, M. Pilar
TI The Pharmacological Activity of Camellia sinensis (L.) Kuntze on
   Metabolic and Endocrine Disorders: A Systematic Review
SO BIOMOLECULES
LA English
DT Review
DE Camellia sinensis; metabolic disorders; endocrine disorders; tea
ID GREEN TEA EXTRACT; HIGH-FAT-DIET; RANKL-INDUCED OSTEOCLASTOGENESIS;
   CARDIOMETABOLIC RISK-FACTORS; GLYCATION END-PRODUCTS; ACTIVITY IN-VITRO;
   BLACK TEA; OXIDATIVE STRESS; INSULIN-RESISTANCE; BODY-COMPOSITION
AB Tea made from Camellia sinensis leaves is one of the most consumed beverages worldwide. This systematic review aims to update Camellia sinensis pharmacological activity on metabolic and endocrine disorders. Inclusion criteria were preclinical and clinical studies of tea extracts and isolated compounds on osteoporosis, hypertension, diabetes, metabolic syndrome, hypercholesterolemia, and obesity written in English between 2014 and 2019 and published in Pubmed, Science Direct, and Scopus. From a total of 1384 studies, 80 reports met inclusion criteria. Most papers were published in 2015 (29.3%) and 2017 (20.6%), conducted in China (28.75%), US (12.5%), and South Korea (10%) and carried out with extracts (67.5%, especially green tea) and isolated compounds (41.25%, especially epigallocatechin gallate). Most pharmacological studies were in vitro and in vivo studies focused on diabetes and obesity. Clinical trials, although they have demonstrated promising results, are very limited. Future research should be aimed at providing more clinical evidence on less studied pathologies such as osteoporosis, hypertension, and metabolic syndrome. Given the close relationship among all endocrine disorders, it would be of interest to find a standard dose of tea or their bioactive constituents that would be beneficial for all of them.
C1 [Sanchez, Marta; Gonzalez-Burgos, Elena; Iglesias, Irene; Gomez-Serranillos, M. Pilar] Univ Complutense Madrid, Fac Pharm, Dept Pharmacol Pharmacognosy & Bot, Plaza Ramon Y Cajal S-N,Ciudad Univ, Madrid 28040, Spain.
   [Lozano, Rafael] Univ Complutense Madrid, Fac Pharm, Dept Chem Pharmaceut Sci, Plaza Ramon Y Cajal S-N,Ciudad Univ, Madrid 28040, Spain.
C3 Complutense University of Madrid; Complutense University of Madrid
RP Gonzalez-Burgos, E (corresponding author), Univ Complutense Madrid, Fac Pharm, Dept Pharmacol Pharmacognosy & Bot, Plaza Ramon Y Cajal S-N,Ciudad Univ, Madrid 28040, Spain.
EM martas15@ucm.es; elenagon@ucm.es; ireneig@ucm.es; rlozano@ucm.es;
   pserra@ucm.es
RI González-Burgos, Elena/H-3471-2017; Lozano, Rafael/G-8694-2015
OI Sanchez Gomez-Serranillos, Marta/0000-0002-5050-9505; Lozano,
   Rafael/0000-0003-1292-6196; GONZALEZ BURGOS, ELENA
   MARIA/0000-0003-2119-8768
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NR 113
TC 20
Z9 24
U1 1
U2 17
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2218-273X
J9 BIOMOLECULES
JI Biomolecules
PD APR
PY 2020
VL 10
IS 4
AR 603
DI 10.3390/biom10040603
PG 28
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA LW9WG
UT WOS:000539492400109
PM 32294991
OA gold, Green Published, Green Accepted
DA 2025-06-11
ER

PT J
AU Yanai, H
   Tomono, Y
   Ito, K
   Furutani, N
   Yoshida, H
   Tada, N
AF Yanai, Hidekatsu
   Tomono, Yoshiharu
   Ito, Kumie
   Furutani, Nobuyuki
   Yoshida, Hiroshi
   Tada, Norio
TI The underlying mechanisms for development of hypertension in the
   metabolic syndrome
SO NUTRITION JOURNAL
LA English
DT Article
ID SYMPATHETIC-NERVOUS-SYSTEM; OBSTRUCTIVE SLEEP-APNEA; C-REACTIVE PROTEIN;
   INSULIN-RESISTANCE; BLOOD-PRESSURE; ENDOTHELIAL DYSFUNCTION; OXIDATIVE
   STRESS; OBESITY; RISK; INTERLEUKIN-6
AB High blood pressure is an important constituent of the metabolic syndrome. However, the underlying mechanisms for development of hypertension in the metabolic syndrome are very complicated and remain still obscure. Visceral/central obesity, insulin resistance, sympathetic overactivity, oxidative stress, endothelial dysfunction, activated renin-angiotensin system, increased inflammatory mediators, and obstructive sleep apnea have been suggested to be possible factors to develop hypertension in the metabolic syndrome. Here, we will discuss how these factors influence on development of hypertension in the metabolic syndrome.
C1 [Yanai, Hidekatsu; Tomono, Yoshiharu; Ito, Kumie; Furutani, Nobuyuki; Tada, Norio] Jikei Univ, Sch Med, Dept Internal Med, Chiba, Japan.
   [Yoshida, Hiroshi] Jikei Univ, Sch Med, Dept Lab Med, Chiba, Japan.
C3 Jikei University; Jikei University
RP Yanai, H (corresponding author), Jikei Univ, Sch Med, Dept Internal Med, Chiba, Japan.
EM yanaih@jikei.ac.jp; tomono@jikei.ac.jp; ito@jikei.ac.jp;
   furutanin@jikei.ac.jp; hyoshida@jikei.ac.jp; n-tada27@jikei.ac.jp
RI Yanai, Hidekatsu/AFN-9517-2022
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NR 61
TC 121
Z9 142
U1 1
U2 10
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1475-2891
J9 NUTR J
JI Nutr. J.
PD APR 17
PY 2008
VL 7
AR 10
DI 10.1186/1475-2891-7-10
PG 6
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 301JD
UT WOS:000255891300001
PM 18416854
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Litteral, V
   Migliozzi, R
   Metzger, D
   Mcpherson, C
   Saldanha, R
AF Litteral, Vaughn
   Migliozzi, Rebecca
   Metzger, David
   Mcpherson, Craig
   Saldanha, Roland
TI Engineering a Cortisol Sensing Enteric Probiotic
SO ACS BIOMATERIALS SCIENCE & ENGINEERING
LA English
DT Article
DE engineered probiotic; probiotics; smart probiotic; gut brain axis;
   Escherichia coli Nissle 1917; EcN; cortisol; glucocorticoid;
   5-alpha-tetrahydrocortisol; adrenal; chronicstress; tryptophan;
   tryptophan decarboxylase; 5-HT; serotonin; tryptamine; lysR
   transcription factor; bacterial sensor; Clostridium scindens; bacterial
   targetedgene integration; biosensor; sense and respond circuit
ID GUT MICROBIOTA; ESCHERICHIA-COLI; SEROTONIN; STRESS; RECEPTOR; SYSTEM;
   LINK
AB Chronic stress can lead to prolonged adrenal gland secretion of cortisol, resulting in human ailments such as anxiety, post-traumatic stress disorder, metabolic syndrome, diabetes, immunosuppression, and cardiomyopathy. Real time monitoring of chronic increases in cortisol and intervening therapies to minimize the physiological effects of stress would be beneficial to prevent these endocrine related illnesses. Gut microbiota have shown the ability to secrete, respond, and even regulate endocrine hormones. One such microbe, Clostridium scindens, responds transcriptionally to cortisol. We engineered these cortisol responsive genetic elements from C. scindens into an enteric probiotic, E. coli Nissle 1917, to drive the expression of a fluorescent reporter allowing for the designing, testing, and building of a robust and physiologically relevant novel cortisol probiotic sensor. This smart probiotic was further engineered to be more sensitive and to respond to elevated cortisol by expressing tryptophan decarboxylase, thereby bestowing the ability to generate tryptamine and serotonin. Here we show that upon cortisol treatment the smart probiotic produces measurable amounts of tryptamine. Accumulated levels of these neuromodulators should improve mood, anxiety, and depression and drive down cortisol levels. Importantly, this work can serve as a model for the engineering of a sense-and-respond probiotic to modulate the gut-brain axis.
C1 [Litteral, Vaughn; Migliozzi, Rebecca; Metzger, David; Mcpherson, Craig] UES Corp, Beavercreek, OH 45432 USA.
   [Litteral, Vaughn; Migliozzi, Rebecca; Metzger, David; Mcpherson, Craig; Saldanha, Roland] Air Force Res Lab, Airman Bioengn Div, Human Performance Wing 711, Wright Patterson Afb, OH 45433 USA.
   [Litteral, Vaughn] POB 49341, Dayton, OH 45449 USA.
C3 UES, Inc.; United States Department of Defense; United States Air Force;
   US Air Force Research Laboratory
RP Litteral, V (corresponding author), UES Corp, Beavercreek, OH 45432 USA.; Litteral, V (corresponding author), Air Force Res Lab, Airman Bioengn Div, Human Performance Wing 711, Wright Patterson Afb, OH 45433 USA.; Litteral, V (corresponding author), POB 49341, Dayton, OH 45449 USA.
EM vaughn.litteral@gmail.com
OI Metzger, David/0000-0002-4547-9970
FU Department of Defense [28]; Office of the Secretary of Defense (OSD),
   through the Tri-Service Applied Research for the Advancement of Science
   and Technology Priorities Program (A.R.A.P.) on Synthetic Biology for
   Military Environments (SBME)
FX The research reported in this publication has been cleared for public
   release ACS under reference number AFRL-2022-3363. This work was funded
   by the Department of Defense 28 (DoD), the Office of the Secretary of
   Defense (OSD), through the Tri-Service Applied Research for the
   Advancement of Science and Technology Priorities Program (A.R.A.P.) on
   Synthetic Biology for Military Environments (SBME).
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NR 57
TC 4
Z9 4
U1 1
U2 4
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 2373-9878
J9 ACS BIOMATER SCI ENG
JI ACS Biomater. Sci. Eng.
PD AUG 30
PY 2023
VL 9
IS 9
BP 5163
EP 5175
DI 10.1021/acsbiomaterials.2c01300
EA AUG 2023
PG 13
WC Materials Science, Biomaterials
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Materials Science
GA R7IG5
UT WOS:001065036200001
PM 37647169
DA 2025-06-11
ER

PT J
AU Landa-Galvan, HV
   Rios-Castro, E
   Romero-Garcia, T
   Rueda, A
   Olivares-Reyes, JA
AF Landa-Galvan, Huguet, V
   Rios-Castro, Emmanuel
   Romero-Garcia, Tatiana
   Rueda, Angelica
   Alberto Olivares-Reyes, Jesus
TI Metabolic syndrome diminishes insulin-induced Akt activation and causes
   a redistribution of Akt-interacting proteins in cardiomyocytes
SO PLOS ONE
LA English
DT Article
ID GLUCOSE-TRANSPORT; DIABETIC CARDIOMYOPATHY; CARDIAC METABOLISM;
   DYSFUNCTION ROLE; RESISTANCE; KINASE; HEAT-SHOCK-PROTEIN-60;
   PHOSPHORYLATION; UBIQUITINATION; DYSREGULATION
AB Metabolic syndrome (MetS) is a cluster of cardiometabolic risk factors, with insulin resistance as a critical component for its development. Insulin signaling in the heart leads to Akt (also known as PKB) activation, a serine/threonine protein kinase, which regulates cardiac glucose metabolism and growth. Cardiac metabolic inflexibility, characterized by impaired insulin-induced glucose uptake and oxidation, has been reported as an early and consistent change in the heart of different models of MetS and diabetes; however, the evaluation of Akt activation has yielded variable results. Here we report in cardiomyocytes of MetS rats, diminished insulin-induced glucose uptake and Akt activation, evaluated by its impaired mobilization towards the plasma membrane and phosphorylation, and reflected in a re-distribution of its interacting proteins, assessed by label-free mass spectrometry (data are available via ProteomeXchange with identifier PXD013260). We report 45 proteins with diminished abundance in Akt complex of MetS cardiomyocytes, mainly represented by energy metabolism-related proteins, and also, 31 Akt-interacting proteins with increased abundance, which were mainly related to contraction, endoplasmic reticulum stress, and Akt negative regulation. These results emphasize the relevance of Akt in the regulation of energy metabolism in the heart and highlight Akt-interacting proteins that could be involved in the detrimental effects of MetS in the heart.
C1 [Landa-Galvan, Huguet, V; Romero-Garcia, Tatiana; Rueda, Angelica; Alberto Olivares-Reyes, Jesus] IPN, CINVESTAV, Dept Bioquim, Mexico City, DF, Mexico.
   [Rios-Castro, Emmanuel] IPN, CINVESTAV, LaNSE, Unidad Genom Prote & Metabolom UGPM, Mexico City, DF, Mexico.
C3 Instituto Politecnico Nacional - Mexico; CINVESTAV - Centro de
   Investigacion y de Estudios Avanzados del Instituto Politecnico
   Nacional; Instituto Politecnico Nacional - Mexico; CINVESTAV - Centro de
   Investigacion y de Estudios Avanzados del Instituto Politecnico Nacional
RP Rueda, A; Olivares-Reyes, JA (corresponding author), IPN, CINVESTAV, Dept Bioquim, Mexico City, DF, Mexico.
EM arueda@cinvestav.mx; jolivare@cinvestav.mx
RI Rueda, Angelica/G-4055-2012; Olivares-Reyes, Jesus Alberto/G-3180-2018
OI Rueda, Angelica/0000-0001-8749-8494; Olivares-Reyes, Jesus
   Alberto/0000-0001-8389-9274; Romero-Garcia, Tatiana/0000-0003-4316-2248;
   Rios-Castro, Emmanuel/0000-0002-7671-7943
FU Cinvestav-IPN; CONACYT/SEP Research Grant [A1-S-9082, 167673];
   PRODEP-SEP grant [Cinvestav-CA-10, 28915/2018]; SEP-CINVESTAV 2018 grant
   [2]; Estimulo a la Investigacion Medica "Miguel Aleman Valdes" 2018;
   CONACYT scholarship grant [278067, 295776]
FX This work was supported by Cinvestav-IPN and partially by CONACYT/SEP
   Research Grant 167673 (to J.A.O-R.); CONACYT/SEP Research Grant
   A1-S-9082 (to A.R.); PRODEP-SEP grant to the Academic Group
   Cinvestav-CA-10, ID 28915/2018 (to A.R. and J.A.O-R.); SEP-CINVESTAV
   2018 grant #2 (to A.R.); Estimulo a la Investigacion Medica "Miguel
   Aleman Valdes" 2018 (to J.A.O-R.) and by a CONACYT scholarship grant,
   No. 278067 (to H.V.L-G.) and No. 295776 (to T.R-G.).
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NR 87
TC 15
Z9 15
U1 1
U2 4
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JAN 29
PY 2020
VL 15
IS 1
AR e0228115
DI 10.1371/journal.pone.0228115
PG 25
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA LP9AX
UT WOS:000534609400047
PM 31995605
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Happell, B
   Ewart, SB
   Platania-Phung, C
   Stanton, R
AF Happell, Brenda
   Ewart, Stephanie B.
   Platania-Phung, Chris
   Stanton, Robert
TI Participative mental health consumer research for improving physical
   health care: An integrative review
SO INTERNATIONAL JOURNAL OF MENTAL HEALTH NURSING
LA English
DT Review
DE action research; consumer participation; mental health; mental illness;
   physical illness; research
ID SERVICE USER RESEARCH; CARDIOVASCULAR RISK; METABOLIC SYNDROME; GOOGLE
   SCHOLAR; MEDICAL-CARE; PEOPLE; ILLNESS; SCHIZOPHRENIA; DISORDERS;
   MORTALITY
AB People with mental illness have a significantly lower life expectancy and higher rates of chronic physical illnesses than the general population. Health care system reform to improve access and quality is greatly needed to address this inequity. The inclusion of consumers of mental health services as co-investigators in research is likely to enhance service reform. In light of this, the current paper reviews mental health consumer focussed research conducted to date, addressing the neglect of physical health in mental health care and initiatives with the aim of improving physical health care. The international literature on physical healthcare in the context of mental health services was searched for articles, including mental health consumers in research roles, via Medline, CINAHL and Google Scholar, in October 2015. Four studies where mental health consumers participated as researchers were identified. Three studies involved qualitative research on barriers and facilitators to physical health care access, and a fourth study on developing technologies for more effective communication between GPs and patients. This review found that participatory mental health consumer research in physical health care reform has only become visible in the academic literature in 2015. Heightened consideration of mental health consumer participation in research is required by health care providers and researchers. Mental health nurses can provide leadership in increasing mental health consumer research on integrated care directed towards reducing the health gap between people with and without mental illness.
C1 [Happell, Brenda; Ewart, Stephanie B.; Platania-Phung, Chris; Stanton, Robert] Univ Canberra, Nursing & Midwifery Res Ctr, Fac Hlth, Canberra, ACT 2601, Australia.
   [Happell, Brenda; Ewart, Stephanie B.; Platania-Phung, Chris; Stanton, Robert] ACT Hlth, Canberra, ACT, Australia.
   [Stanton, Robert] Cent Queensland Univ, Sch Med & Appl Sci, Rockhampton, Qld 4702, Australia.
C3 University of Canberra; ACT Health Australia; Central Queensland
   University
RP Happell, B (corresponding author), Univ Canberra, Nursing & Midwifery Res Ctr, Fac Hlth, ACT Hlth,Canberra Hosp, Bldg 6,Level 3,POB 11, Woden, ACT 2606, Australia.
EM brenda.happell@canberra.edu.au
RI Stanton, Rob/AAJ-5157-2020; Happell, Brenda/HSI-0570-2023
OI Happell, Brenda/0000-0002-7293-6583
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NR 61
TC 21
Z9 21
U1 3
U2 27
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1445-8330
EI 1447-0349
J9 INT J MENT HEALTH NU
JI Int. J. Ment. Health Nurs.
PD OCT
PY 2016
VL 25
IS 5
BP 399
EP 408
DI 10.1111/inm.12226
PG 10
WC Nursing; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Psychiatry
GA DX6XH
UT WOS:000384528800002
PM 27159221
OA Green Published
DA 2025-06-11
ER

PT J
AU Karaman, ME
   Arslan, C
   Gürsu, MF
   Güngör, HI
   Arkali, G
   Yüce, A
   Türk, G
AF Karaman, Muhammed Emre
   Arslan, Cengiz
   Gursu, Mehmet Ferit
   Gungor, Halil Ibrahim
   Arkali, Gozde
   Yuce, Abdurraif
   Turk, Gaffari
TI Moderate Aerobic Exercise May Reduce Metabolic Syndrome Induced
   Testicular Oxidative Stress and Deterioration in Sperm Parameters
SO JOURNAL OF PHARMACEUTICAL RESEARCH INTERNATIONAL
LA English
DT Article
DE Aerobic exercise; anaerobic exercise; metabolic syndrome; testis
   oxidative stress; sperm parameters
ID QUALITY; DAMAGE
AB Aims: Studies on testicular oxidative stress, sperm density, motility and morphology of exercise applications in the case of metabolic syndrome is limited. In the present study, it was aimed to investigate the effects of aerobic and anaerobic exercise applications on sperm parameters and testicular oxidative stress parameters in metabolic syndrome induced rats.
   Study Design: Controlled Trial.
   Place and Duration of Study: Firat University Experimental Research Center, Elazig/Turkey.
   Methodology: A total of 24 male Wistar-Albino rats were used in the study. For inducing the metabolic syndrome, 30% fructose solution was prepared fresh every day and administered ad-libitum through the drinking water of the animals. The rats were divided into 4 groups (G1: Control, G2: Metabolic Syndrome, G3: Metabolic Syndrome + Aerobic Ex., G4: Metabolic Syndrome + Anaerobic Ex.). Exercise practices continued 3 days in a week for 6 weeks.
   Results: Sperm concentrations of G2 and G4 were statistically significantly lower than the control group. The abnormality percentage of G4 was statistically significantly higher than the other groups in terms of head abnormality and total abnormality. MDA level of G2 was statistically significantly higher than the other groups, while GSHpx and catalase levels were low.
   Conclusion: It can be said that metabolic syndrome may cause oxidative damage in testicular tissue and deterioration in sperm parameters. Moderate-intensity aerobic exercise reduces the deterioration in sperm parameters by creating a protective response against oxidative damage.
C1 [Karaman, Muhammed Emre; Arslan, Cengiz] Firat Univ, Fac Sport Sci, Dept Coaching Training, Elazig, Turkey.
   [Gursu, Mehmet Ferit] Firat Univ, Fac Med, Dept Med Biochem, Elazig, Turkey.
   [Gungor, Halil Ibrahim; Turk, Gaffari] Firat Univ, Fac Vet Med, Dept Reprod & Artificial Inseminat, Elazig, Turkey.
   [Arkali, Gozde; Yuce, Abdurraif] Firat Univ, Fac Vet Med, Dept Physiol, Elazig, Turkey.
C3 Firat University; Firat University; Firat University; Firat University
RP Karaman, ME (corresponding author), Firat Univ, Fac Sport Sci, Dept Coaching Training, Elazig, Turkey.
EM mekaraman@firat.edu.tr
RI KARAMAN, Muhammed Emre/W-4999-2018; Turk, Gaffari/V-6922-2018; Arkalı,
   Gözde/W-1356-2018; GÜRSU, MEHMET/HJZ-1663-2023; ARSLAN,
   CENGIZ/O-7448-2018
OI KARAMAN, Muhammed Emre/0000-0003-0800-8093; Turk,
   Gaffari/0000-0001-7417-1038; ARSLAN, CENGIZ/0000-0003-4406-1131
FU Firat University Scientific Research Projects Unit (FUBAP); Firat
   University Experimental Research Center
FX This study was undertaken in Firat University. The authors thank the
   following for their assistance and contribution to the development and
   achievement of this research; Firat University Scientific Research
   Projects Unit (FUBAP) and Firat University Experimental Research Center.
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NR 26
TC 7
Z9 7
U1 1
U2 9
PU SCIENCEDOMAIN INT
PI GURGAON
PA SCIENCEDOMAIN INT, GURGAON, 00000, INDIA
SN 2456-9119
J9 J PHARM RES INT
JI J. Pharm. Res. Int.
PY 2021
VL 33
IS 11
BP 38
EP 45
DI 10.9734/JPRI/2021/v33i1131242
PG 8
WC Pharmacology & Pharmacy
WE Emerging Sources Citation Index (ESCI)
SC Pharmacology & Pharmacy
GA QY0PV
UT WOS:000629747100005
OA gold
DA 2025-06-11
ER

PT J
AU Barbagallo, F
   Cucinella, L
   Tiranini, L
   Chedraui, P
   Calogero, AE
   Nappi, RE
AF Barbagallo, F.
   Cucinella, L.
   Tiranini, L.
   Chedraui, P.
   Calogero, A. E.
   Nappi, R. E.
TI Obesity and sexual health: focus on postmenopausal women
SO CLIMACTERIC
LA English
DT Review; Early Access
DE Sexual function; obesity; overweight; menopause; female sexual
   dysfunction; anti-obesity interventions
ID BODY-MASS INDEX; QUALITY-OF-LIFE; METABOLIC SYNDROME; MEDITERRANEAN
   DIET; ADIPOSE-TISSUE; CARDIOMETABOLIC RISK; VASOMOTOR SYMPTOMS;
   PHYSICAL-ACTIVITY; DESIRE DISORDER; MENTAL-HEALTH
AB Menopause is a cardiometabolic transition with many women experiencing weight gain and redistribution of body fat. Hormonal changes may affect also several dimensions of well-being, including sexual function, with a high rate of female sexual dysfunction (FSD), which displays a multifactorial etiology. The most important biological factors range from chronic low-grade inflammation, associated with hypertrophic adipocytes that may translate into endothelial dysfunction and compromised blood flow through the genitourinary system, to insulin resistance and other neuroendocrine mechanisms targeting the sexual response. Psychosocial factors include poor body image, mood disorders, low self-esteem and life satisfaction, as well as partner's health and quality of relationship, and social stigma. Even unhealthy lifestyle, chronic conditions and putative weight-promoting medications may play a role. The aim of the present narrative review is to update and summarize the state of the art on the link between obesity and FSD in postmenopausal women, pointing to the paucity of high-quality studies and the need for further research with validated end points to assess both biomarkers of obesity and FSD. In addition, we provide general information on the diagnosis and treatment of FSD at menopause with a focus on dietary interventions, physical activity, anti-obesity drugs and bariatric surgery.
C1 [Barbagallo, F.; Calogero, A. E.] Univ Catania, Dept Clin & Expt Med, Catania, Italy.
   [Cucinella, L.; Tiranini, L.; Nappi, R. E.] Univ Pavia, Dept Clin Surg Diagnost & Pediat Sci, Pavia, Italy.
   [Cucinella, L.; Nappi, R. E.] IRCCS San Matteo Fdn, Res Ctr Reprod Med Gynecol Endocrinol & Menopause, Pavia, Italy.
   [Chedraui, P.] Univ Espiritu Santo, Escuela Posgrad Salud, Samborondon, Ecuador.
   [Nappi, R. E.] Univ Pavia, Dept Clin Surg Diagnost & Pediat Sci, Piazzale Golgi 2, I-27100 Pavia, Italy.
C3 University of Catania; University of Pavia; IRCCS Fondazione San Matteo;
   Universidad de Especialidades Espiritu Santo; University of Pavia
RP Nappi, RE (corresponding author), Univ Pavia, Dept Clin Surg Diagnost & Pediat Sci, Pavia, Italy.; Nappi, RE (corresponding author), Univ Pavia, Dept Clin Surg Diagnost & Pediat Sci, Piazzale Golgi 2, I-27100 Pavia, Italy.
EM nappi@rossellanappi.com
RI Barbagallo, Federica/AAB-6446-2021; Calogero, Aldo/AAA-9538-2021;
   Blümel, Juan Enrique/JUV-6950-2023; Nappi, Rossella/AAC-1793-2022
OI Nappi, Rossella/0000-0003-1713-6396; Chedraui, Peter/0000-0002-1556-3979
FU European Campus of City-Universities (EC2U) Alliance; European Campus of
   City-Universities (EC2U) Alliance [101004065-EC2U]
FX R. E. Nappi and L. Cucinella received funding from European Campus of
   City-Universities (EC2U) Alliance [Grant Agreement n. 101004065-EC2U]
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NR 189
TC 5
Z9 5
U1 4
U2 11
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1369-7137
EI 1473-0804
J9 CLIMACTERIC
JI Climacteric
PD 2024 JAN 20
PY 2024
DI 10.1080/13697137.2024.2302429
EA JAN 2024
PG 15
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA FP4Z5
UT WOS:001147049500001
PM 38251874
OA Bronze
DA 2025-06-11
ER

PT J
AU Jagannath, A
   Taylor, L
   Wakaf, Z
   Vasudevan, SR
   Foster, RG
AF Jagannath, Aarti
   Taylor, Lewis
   Wakaf, Zeinab
   Vasudevan, Sridhar R.
   Foster, Russell G.
TI The genetics of circadian rhythms, sleep and health
SO HUMAN MOLECULAR GENETICS
LA English
DT Review
ID TOTALLY BLIND PEOPLE; BIPOLAR-I-DISORDER; CLOCK GENE; SCHIZOAFFECTIVE
   DISORDER; T3111C POLYMORPHISM; ALZHEIMERS-DISEASE; METABOLIC SYNDROME;
   MOLECULAR CLOCK; PHASE SYNDROME; ASSOCIATION
AB Circadian rhythms are 24-h rhythms in physiology and behaviour generated by molecular clocks, which serve to coordinate internal time with the external world. The circadian system is a master regulator of nearly all physiology and its disruption has major consequences on health. Sleep and circadian rhythm disruption (SCRD) is a ubiquitous feature in today's 24/7 society, and studies on shift-workers have shown that SCRD can lead not only to cognitive impairment, but also metabolic syndrome and psychiatric illness including depression (1,2). Mouse models of clock mutants recapitulate these deficits, implicating mechanistic and causal links between SCRD and disease pathophysiology (3-5). Importantly, treating clock disruption reverses and attenuates these adverse health states in animal models (6,7), thus establishing the circadian system as a novel therapeutic target. Significantly, circadian and clock-controlled gene mutations have recently been identified by Genome-Wide Association Studies (GWAS) in the aetiology of sleep, mental health and metabolic disorders. This review will focus upon the genetics of circadian rhythms in sleep and health.
C1 [Jagannath, Aarti; Taylor, Lewis; Foster, Russell G.] Univ Oxford, Sleep & Circadian Neurosci Inst, Sir William Dunn Sch Pathol, OMPI G, Oxford OX1 3RE, England.
   [Wakaf, Zeinab; Vasudevan, Sridhar R.] Univ Oxford, Dept Pharmacol, Mansfield Rd, Oxford OX1 3QT, England.
C3 University of Oxford; University of Oxford
RP Jagannath, A; Foster, RG (corresponding author), Univ Oxford, Sleep & Circadian Neurosci Inst, Sir William Dunn Sch Pathol, OMPI G, Oxford OX1 3RE, England.
EM aarti.jagannath@ndcn.ox.ac.uk; russell.foster@eye.ox.ac.uk
RI Jagannath, Aarti/GQA-7297-2022
OI FOSTER, RUSSELL/0000-0001-6055-2067; Jagannath,
   Aarti/0000-0003-2132-8200
FU BBSRC [BB/N01992X/1, BB/N001664/1]; Wellcome Trust [106174/Z/14/Z]; Said
   Foundation; Circadian Therapeutics; BBSRC [BB/N01992X/1, BB/N001664/1]
   Funding Source: UKRI; Wellcome Trust [106174/Z/14/Z] Funding Source:
   Wellcome Trust
FX We would like to acknowledge the following sources of funding: BBSRC
   ref. BB/N01992X/1 to AJ, Wellcome Trust ref. 106174/Z/14/Z to RGF, BBSRC
   ref. BB/N001664/1 to SV, and a Said Foundation scholarship to ZW. AJ,
   SRV and RGF are in receipt of funding from Circadian Therapeutics.
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NR 107
TC 157
Z9 180
U1 3
U2 58
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0964-6906
EI 1460-2083
J9 HUM MOL GENET
JI Hum. Mol. Genet.
PD OCT 1
PY 2017
VL 26
IS R2
BP R128
EP R138
DI 10.1093/hmg/ddx240
PG 11
WC Biochemistry & Molecular Biology; Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Biochemistry & Molecular Biology; Genetics & Heredity
GA FO9CD
UT WOS:000417184700005
PM 28977444
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU de Vries, J
   DeJongste, MJL
   Jessurun, GAJ
   Jager, PL
   Staal, MJ
   Slart, RHJA
AF de Vries, Jessica
   DeJongste, Mike J. L.
   Jessurun, Gillian A. J.
   Jager, Pieter L.
   Staal, Michiel J.
   Slart, Riemer H. J. A.
TI Myocardial perfusion quantification in patients suspected of cardiac
   syndrome X with positive and negative exercise testing:: A
   [<SUP>13</SUP>N]ammonia positron emission tomography study
SO NUCLEAR MEDICINE COMMUNICATIONS
LA English
DT Article
DE cardiac syndrome X; exercise testing; positron emission tomography
ID NORMAL CORONARY-ARTERIES; ST-SEGMENT DEPRESSION; CHEST-PAIN;
   ANGINA-PECTORIS; FLOW RESERVE; ARTERIOGRAMS; ISCHEMIA
AB Background The combination of angina pectoris, angiographically normal coronary arteries, and a positive exercise stress test (EST) is referred to as cardiac syndrome X. However, a large group of patients suspected of syndrome X reveals a normal exercise stress test and weakens the diagnosis of syndrome X. Previous studies demonstrated an impaired coronary flow reserve on ammonia positron emission tomography (PET) in patients with syndrome X.
   Aim To evaluate the coronary flow reserve in patients suspected of syndrome X with positive and negative EST findings, using [N-13]ammonia PET as the diagnostic aid.
   Methods Forty-two patients with chest pain and a normal coronary angiography, were analysed by exercise stress testing (EST) and the dypyridamole stress test (DST) on [N-13]ammonia PET Two subgroups were predefined, based on outcome of EST: an EST positive and negative group. A normal control group was used as the reference method.
   Results A total of 24 (57%) out of 42 patients had significant ST-T changes (EST positive). [N-13]ammonia PET showed a significantly lower rest flow in the EST positive and EST negative group compared to controls (P < 0.001 and P = 0.0028, respectively). DST [N-13]ammonia PET perfusion was significantly reduced in flow in both the EST positive and EST negative groups (P < 0.001 both), as was the DST/rest [N-13]ammonia perfusion reserve (P < 0.001 for both), compared to normal controls.
   Conclusion PET demonstrates a reduced coronary flow reserve in patients suspected of syndrome X, irrespective of the EST findings.
C1 Univ Groningen, Ctr Med, Dept Nucl Med & Mol Imaging, NL-9700 RB Groningen, Netherlands.
   Univ Groningen, Ctr Med, Fac Med, Dept Cardiol,Thoraxctr, NL-9700 RB Groningen, Netherlands.
   Univ Groningen, Ctr Med, Dept Neurosurg, NL-9700 RB Groningen, Netherlands.
C3 University of Groningen; University of Groningen; University of
   Groningen
RP Slart, RHJA (corresponding author), Univ Groningen, Ctr Med, Dept Nucl Med & Mol Imaging, Hanzeplein 1,POB 30001, NL-9700 RB Groningen, Netherlands.
EM r.h.j.a.slart@nucl.umcg.nl
RI Jager, Pieter/A-3672-2017
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NR 22
TC 13
Z9 15
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0143-3636
J9 NUCL MED COMMUN
JI Nucl. Med. Commun.
PD OCT
PY 2006
VL 27
IS 10
BP 791
EP 794
DI 10.1097/01.mnm.0000237984.46844.42
PG 4
WC Radiology, Nuclear Medicine & Medical Imaging
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Radiology, Nuclear Medicine & Medical Imaging
GA 092IA
UT WOS:000241089000007
PM 16969261
DA 2025-06-11
ER

PT J
AU Thaker, VV
   Osganian, SK
   deFerranti, SD
   Sonneville, KR
   Cheng, JK
   Feldman, HA
   Richmond, TK
AF Thaker, Vidhu V.
   Osganian, Stavroula K.
   deFerranti, Sarah D.
   Sonneville, Kendrin R.
   Cheng, Jennifer K.
   Feldman, Henry A.
   Richmond, Tracy K.
TI Psychosocial, behavioral and clinical correlates of children with
   overweight and obesity
SO BMC PEDIATRICS
LA English
DT Article
DE Childhood obesity; Psychosocial; Behavioral
ID C-REACTIVE PROTEIN; QUALITY-OF-LIFE; CHILDHOOD OBESITY; EMOTION
   REGULATION; METABOLIC SYNDROME; MEDIATING ROLE; RISK-FACTOR;
   ADOLESCENTS; DEPRESSION; INFLAMMATION
AB Background Psychological and behavioral correlates are considered important in the development and persistence of obesity in both adults and youth. This study aimed to identify such features in youth with severe obesity (BMI >= 120% of 95(th)percentile of sex-specific BMI-for-age) compared to those with overweight or non-severe obesity. Methods Youth with BMI >= 85(th)percentile were invited to participate in a prospective research registry where data was collected on attributes such as family characteristics, eating behaviors, dietary intake, physical activity, perception of health and mental well-being, and cardiometabolic parameters. Results In a racially/ethnically diverse cohort of 105 youth (65% female, median age 16.1 years, range 4.62-25.5), 51% had severe obesity. The body fat percent increased with the higher levels of obesity. There were no differences in the self-reported frequency of intake of sugar sweetened beverages or fresh produce across the weight categories. However, the participants with severe obesity reported higher levels of emotional eating and eating when bored (p = 0.022), levels of stress (p = 0.013), engaged in fewer sports or organized activities (p = 0.044), and had suboptimal perception of health (p = 0.053). Asthma, depression and obstructive sleep apnea were more frequently reported in youth with severe obesity. The presence of abnormal HDL-C, HOMA-IR, hs-CRP and multiple cardiometabolic risk factors were more common among youth with severe obesity. Conclusions Youth with severe obesity have identifiable differences in psychosocial and behavioral attributes that can be used to develop targeted intervention strategies to improve their health.
C1 [Thaker, Vidhu V.] Columbia Univ, Dept Pediat, Div Mol Genet, Irving Med Ctr, 1150 St Nicholas Ave, New York, NY 10032 USA.
   [Osganian, Stavroula K.] NIDDK, NIH, Bethesda, MD 20892 USA.
   [deFerranti, Sarah D.] Boston Childrens Hosp, Div Ambulatory Cardiol, Dept Cardiol, Boston, MA 02115 USA.
   [deFerranti, Sarah D.; Cheng, Jennifer K.; Richmond, Tracy K.] Harvard Med Sch, Dept Pediat, Boston, MA 02115 USA.
   [Sonneville, Kendrin R.] Univ Michigan, Sch Publ Hlth, Ann Arbor, MI 48109 USA.
   [Cheng, Jennifer K.] Boston Childrens Hosp, Div Primary Care, Boston, MA 02115 USA.
   [Feldman, Henry A.] Boston Childrens Hosp, Inst Ctr Clin & Translat Res, Boston, MA 02115 USA.
   [Richmond, Tracy K.] Boston Childrens Hosp, Div Adolescent Young Adult Med, Boston, MA 02115 USA.
C3 Columbia University; NewYork-Presbyterian Hospital; National Institutes
   of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive &
   Kidney Diseases (NIDDK); Harvard University; Harvard University Medical
   Affiliates; Boston Children's Hospital; Harvard University; Harvard
   Medical School; University of Michigan System; University of Michigan;
   Harvard University; Harvard University Medical Affiliates; Boston
   Children's Hospital; Harvard University; Harvard University Medical
   Affiliates; Boston Children's Hospital; Harvard University; Harvard
   University Medical Affiliates; Boston Children's Hospital
RP Thaker, VV (corresponding author), Columbia Univ, Dept Pediat, Div Mol Genet, Irving Med Ctr, 1150 St Nicholas Ave, New York, NY 10032 USA.
EM vvt2114@cumc.columbia.edu
RI Feldman, Henry/M-2302-2013; Thaker, Vidhu/K-6959-2019
OI Thaker, Vidhu/0000-0002-3537-2782
FU Milton Fund, New Balance Foundation Obesity Prevention Center; Boston
   Children's Hospital; NIH-NIDDK [K23 DK 110539]; National Institute of
   Diabetes and Digestive and Kidney Diseases [K23DK110539] Funding Source:
   NIH RePORTER
FX The POOL registry was funded in part by Milton Fund, New Balance
   Foundation Obesity Prevention Center, and Boston Children's Hospital for
   the resources required to enroll participants and conduct sample
   collection and laboratory studies. VVT is partly supported for research
   career development by NIH-NIDDK K23 DK 110539.
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NR 56
TC 13
Z9 14
U1 2
U2 15
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2431
J9 BMC PEDIATR
JI BMC Pediatr.
PD JUN 10
PY 2020
VL 20
IS 1
AR 291
DI 10.1186/s12887-020-02145-2
PG 11
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Pediatrics
GA MA9SW
UT WOS:000542251400002
PM 32522176
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Chitrala, KN
   Hernandez, DG
   Nalls, MA
   Mode, NA
   Zonderman, AB
   Ezike, N
   Evans, MK
AF Chitrala, Kumaraswamy Naidu
   Hernandez, Dena G.
   Nalls, Michael A.
   Mode, Nicolle A.
   Zonderman, Alan B.
   Ezike, Ngozi
   Evans, Michele K.
TI Race-specific alterations in DNA methylation among middle-aged African
   Americans and Whites with metabolic syndrome
SO EPIGENETICS
LA English
DT Article
DE Metabolic syndrome; methylation; race; health disparities; epigenomic
   wide association study; African Americans
ID OXIDATIVE STRESS; CANCER; RISK; ASSOCIATION; MICROARRAY; PROTEIN; GENE;
   DECONVOLUTION; ADHESION; PACKAGE
AB Metabolic syndrome (MetS) is a cluster of cardiometabolic risk factors for all-cause mortality, cardiovascular disease, and cancer. Identifying epigenetic alterations associated with MetS in African Americans (AAs) and Whites may provide insight into genes that influence its differential health outcomes. We examined DNA methylation (DNAm) and performed an epigenome-wide association study (EWAS) of MetS among AAs and Whites with and without MetS. We assessed age, race and poverty status associated DNAm among AAs (n = 225) and White (n = 233) adults using NCEP-ATP III guidelines. Genome-wide DNAm measurement was assessed using Illumina Infinium Methylation EPIC BeadChip. Differentially methylated positions (DMPs) and differentially methylated regions (DMRs) were identified using dmpFinder and bumphunter. EWAS was performed using CpGassoc. We found significant DMPs associated with age, poverty status and MetS in each race. GSTT1(Glutathione S-Transferase Theta 1) was one of the top-hypermethylated genes and MIPEP (Mitochondrial Intermediate Peptidase) was one of the most hypomethylated genes when comparing AAs with and without MetS. PPP1R13L (Protein Phosphatase 1 Regulatory Subunit 13 Like) was the top hypermethylated and SCD (stearoyl-CoA desaturase-1) was one of the most hypomethylated genes for Whites with and without MetS. EWAS results showed that DNAm differences might contribute to MetS risk among Whites and AAs since different genes were identified in AAs and Whites. We replicated previously identified MetS associated genes and found that Thioredoxin-interacting protein (TXN1P) was statistically significantly differentially expressed only in Whites. Our results may be useful in further studies of genes underlying differences in MetS among AAs and Whites.
C1 [Chitrala, Kumaraswamy Naidu; Mode, Nicolle A.; Zonderman, Alan B.; Ezike, Ngozi; Evans, Michele K.] NIA, Lab Epidemiol & Populat Sci, NIH, Baltimore, MD 21224 USA.
   [Hernandez, Dena G.; Nalls, Michael A.] NIA, Lab Neurogenet, NIH, Bethesda, MD 21224 USA.
   [Nalls, Michael A.] Data Tecn Int, Glen Echo, MD USA.
C3 National Institutes of Health (NIH) - USA; NIH National Institute on
   Aging (NIA); National Institutes of Health (NIH) - USA; NIH National
   Institute on Aging (NIA)
RP Evans, MK (corresponding author), NIA, Lab Epidemiol & Populat Sci, NIH, Biomed Res Ctr, 251 Bayview Blvd,Suite 100,Room 4C-222, Baltimore, MD 21224 USA.
EM me42v@nih.gov
RI Mode, Nicolle/A-6804-2011; Ezike, Ngozi/AAL-3075-2021; Zonderman,
   Alan/A-5807-2013; Evans, Michele/AAE-4776-2019; Chitrala,
   Kumara/U-1617-2019
OI Mode, Nicolle/0000-0002-8193-0554; Evans, Michele/0000-0002-8546-2831;
   Chitrala, Kumaraswamy naidu/0000-0003-0663-9529
FU National Institute on Aging (NIA), the National Institutes of Health
   (NIH), Baltimore, Maryland [AG000989]; National Institute on Aging
   [ZIAAG000519] Funding Source: NIH RePORTER
FX This project was funded by the Interlaboratory Proposal Funding of the
   Intramural Research Program of the National Institute on Aging (NIA),
   the National Institutes of Health (NIH), Baltimore, Maryland. Funding
   number: [AG000989].
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   2016, ILLUMINAHUMANMETHYLA
NR 74
TC 43
Z9 44
U1 0
U2 7
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1559-2294
EI 1559-2308
J9 EPIGENETICS-US
JI Epigenetics
PD MAY 3
PY 2020
VL 15
IS 5
BP 462
EP 482
DI 10.1080/15592294.2019.1695340
EA DEC 2019
PG 21
WC Biochemistry & Molecular Biology; Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Genetics & Heredity
GA LE0VR
UT WOS:000501030600001
PM 31739726
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Bowles, NP
   Karatsoreos, IN
   Li, XS
   Vemuri, VK
   Wood, JA
   Li, ZY
   Tamashiro, KLK
   Schwartz, GJ
   Makriyannis, AM
   Kunos, G
   Hillard, CJ
   McEwen, BS
   Hill, MN
AF Bowles, Nicole P.
   Karatsoreos, Ilia N.
   Li, Xiaosong
   Vemuri, V. Kiran
   Wood, Jodi-Anne
   Li, Zhiying
   Tamashiro, Kellie L. K.
   Schwartz, Gary J.
   Makriyannis, Alexandros M.
   Kunos, George
   Hillard, Cecilia J.
   McEwen, Bruce S.
   Hill, Matthew N.
TI A peripheral endocannabinoid mechanism contributes to
   glucocorticoid-mediated metabolic syndrome
SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF
   AMERICA
LA English
DT Article
DE corticosterone; 2-AG; anandamide; obesity; liver
ID INDUCED INSULIN-RESISTANCE; STRESS-INDUCED OBESITY; ADIPOSE-TISSUE;
   CARDIOMETABOLIC RISK; CB1 RECEPTOR; FOOD-INTAKE; LEPTIN; DIET;
   DEXAMETHASONE; ANANDAMIDE
AB Glucocorticoids are known to promote the development of metabolic syndrome through the modulation of both feeding pathways and metabolic processes; however, the precise mechanisms of these effects are not well-understood. Recent evidence shows that glucocorticoids possess the ability to increase endocannabinoid signaling, which is known to regulate appetite, energy balance, and metabolic processes through both central and peripheral pathways. The aim of this study was to determine the role of endocannabinoid signaling in glucocorticoid-mediated obesity and metabolic syndrome. Using a mouse model of excess corticosterone exposure, we found that the ability of glucocorticoids to increase adiposity, weight gain, hormonal dysregulation, hepatic steatosis, and dyslipidemia was reduced or reversed in mice lacking the cannabinoid CB1 receptor as well as mice treated with the global CB1 receptor antagonist AM251. Similarly, a neutral, peripherally restricted CB1 receptor antagonist (AM6545) was able to attenuate the metabolic phenotype caused by chronic corticosterone, suggesting a peripheral mechanism for these effects. Biochemical analyses showed that chronic excess glucocorticoid exposure produced a significant increase in hepatic and circulating levels of the endocannabinoid anandamide, whereas no effect was observed in the hypothalamus. To test the role of the liver, specific and exclusive deletion of hepatic CB1 receptor resulted in a rescue of the dyslipidemic effects of glucocorticoid exposure, while not affecting the obesity phenotype or the elevations in insulin and leptin. Together, these data indicate that glucocorticoids recruit peripheral endocannabinoid signaling to promote metabolic dysregulation, with hepatic endocannabinoid signaling being especially important for changes in lipid metabolism.
C1 [Bowles, Nicole P.; Karatsoreos, Ilia N.; McEwen, Bruce S.; Hill, Matthew N.] Rockefeller Univ, Neuroendocrinol Lab, New York, NY 10065 USA.
   [Li, Zhiying] Rockefeller Univ, Mol Genet Lab, New York, NY 10065 USA.
   [Karatsoreos, Ilia N.] Washington State Univ, Dept Integrat Physiol & Neurosci, Pullman, WA 99164 USA.
   [Li, Xiaosong; Schwartz, Gary J.] Yeshiva Univ Albert Einstein Coll Med, Dept Med, Bronx, NY 10461 USA.
   [Li, Xiaosong; Schwartz, Gary J.] Yeshiva Univ Albert Einstein Coll Med, Dept Neurosci, Bronx, NY 10461 USA.
   [Vemuri, V. Kiran; Wood, Jodi-Anne; Makriyannis, Alexandros M.] Northeastern Univ, Dept Pharmaceut Sci, Ctr Drug Discovery, Boston, MA 02115 USA.
   [Vemuri, V. Kiran; Wood, Jodi-Anne; Makriyannis, Alexandros M.] Northeastern Univ, Dept Chem & Chem Biol, Boston, MA 02115 USA.
   [Tamashiro, Kellie L. K.] Johns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, Baltimore, MD 21205 USA.
   [Kunos, George] NIAAA, NIH, Bethesda, MD 20892 USA.
   [Hillard, Cecilia J.] Med Coll Wisconsin, Dept Pharmacol & Toxicol, Milwaukee, WI 53226 USA.
   [Hillard, Cecilia J.] Med Coll Wisconsin, Neurosci Res Ctr, Milwaukee, WI 53226 USA.
   [Hill, Matthew N.] Univ Calgary, Hotchkiss Brain Inst, Dept Cell Biol & Anat, Calgary, AB T2N 4N1, Canada.
   [Hill, Matthew N.] Univ Calgary, Hotchkiss Brain Inst, Dept Psychiat, Calgary, AB T2N 4N1, Canada.
C3 Rockefeller University; Rockefeller University; Washington State
   University; Yeshiva University; Montefiore Medical Center; Albert
   Einstein College of Medicine; Montefiore Medical Center; Albert Einstein
   College of Medicine; Yeshiva University; Northeastern University;
   Northeastern University; Johns Hopkins University; National Institutes
   of Health (NIH) - USA; NIH National Institute on Alcohol Abuse &
   Alcoholism (NIAAA); Medical College of Wisconsin; Medical College of
   Wisconsin; University of Calgary; University of Calgary
RP Bowles, NP (corresponding author), Rockefeller Univ, Neuroendocrinol Lab, New York, NY 10065 USA.
EM nbowles@mail.rockefeller.edu; mcewen@mail.rockefeller.edu;
   mnhill@ucalgary.ca
RI LI, XIAOSONG/GLT-3551-2022; Hillard, Cecilia/O-6693-2018; McEwen,
   Bruce/Z-1630-2019; Karatsoreos, Ilia/AAR-8774-2020; Makriyannis,
   Alexandros/GRF-1518-2022; Hill, Matthew/J-4610-2013
OI Tamashiro, Kellie/0000-0002-9398-8796; Hillard,
   Cecilia/0000-0002-9678-748X
FU Hope for Depression Research Foundation; Johnson and Johnson
   Pharmaceuticals; NIH Einstein DRTC Animal Physiology Core [DK 020541,
   DA9158, DA23142, DA026996]; Research and Education Component of the
   Advancing a Healthier Wisconsin Endowment; National Institute on Alcohol
   Abuse and Alcoholism, NIH; Ford Foundation Fellowship; Tier II Canada
   Research Chair; Natural Sciences and Engineering Research Council of
   Canada
FX We thank Sarah Bhagat for her technical assistance at the early stage of
   this study. This research was supported, in part, by an operating grant
   from the Hope for Depression Research Foundation and an unrestricted
   operating grant from Johnson and Johnson Pharmaceuticals (to B.S.M.).
   NIH Grants DK 020541 Einstein DRTC Animal Physiology Core (to G.J.S.),
   DA9158 (to A.M.M.), DA23142 (to A.M.M.), and DA026996 (to C.J.H.); the
   Research and Education Component of the Advancing a Healthier Wisconsin
   Endowment to the Medical College of Wisconsin; and intramural funds from
   the National Institute on Alcohol Abuse and Alcoholism, NIH (G.K.) also
   supported this research. N.P.B. was a recipient of a predoctoral Ford
   Foundation Fellowship. M.N.H. is the recipient of a Tier II Canada
   Research Chair, and this research was supported by an operating grant
   from the Natural Sciences and Engineering Research Council of Canada.
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NR 61
TC 84
Z9 90
U1 0
U2 25
PU NATL ACAD SCIENCES
PI WASHINGTON
PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA
SN 0027-8424
J9 P NATL ACAD SCI USA
JI Proc. Natl. Acad. Sci. U. S. A.
PD JAN 6
PY 2015
VL 112
IS 1
BP 285
EP 290
DI 10.1073/pnas.1421420112
PG 6
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA AY2WN
UT WOS:000347447100067
PM 25535367
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Maseroli, E
   Fanni, E
   Cipriani, S
   Scavello, I
   Pampaloni, F
   Battaglia, C
   Fambrini, M
   Mannucci, E
   Jannini, EA
   Maggi, M
   Vignozzi, L
AF Maseroli, Elisa
   Fanni, Egidia
   Cipriani, Sarah
   Scavello, Irene
   Pampaloni, Francesca
   Battaglia, Cesare
   Fambrini, Massimiliano
   Mannucci, Edoardo
   Jannini, Emmanuele A.
   Maggi, Mario
   Vignozzi, Linda
TI Cardiometabolic Risk and Female Sexuality: Focus on Clitoral Vascular
   Resistance
SO JOURNAL OF SEXUAL MEDICINE
LA English
DT Article
DE Clitoris; Ultrasound; Genital Blood Flow; Cardiovascular Risk; Metabolic
   Syndrome; Female Sexual Dysfunction
ID ERECTILE DYSFUNCTION; METABOLIC SYNDROME; MENSTRUAL-CYCLE;
   CARDIOVASCULAR-DISEASE; POSTMENOPAUSAL WOMEN; PREMENOPAUSAL WOMEN;
   VAGINAL ENGORGEMENT; PULSATILITY INDEX; RATING-SCALE; BODY-IMAGE
AB Introduction: The relation between sexual and cardiovascular health in women is not well defined. Clitoral color Doppler ultrasound (CDU) with assessment of the pulsatility index (PI), reflecting resistance to blood flow, has been proposed as an objective measurement of sexual functioning.
   Aim: To investigate associations between clitoral PI and cardiometabolic risk factors, sexual and intrapsychic parameters, and self-perception of body image.
   Methods: Seventy-one adult heterosexual women in a stable relationship attending our clinic for sexual dysfunction were consecutively recruited.
   Main Outcome Measures: Patients underwent physical, laboratory, and clitoral color Doppler ultrasound examinations and completed the Female Sexual Function Index, the Middlesex Hospital Questionnaire, and the Body Uneasiness Test (BUT).
   Results: Clitoral PI was positively correlated with body mass index (r = 0.441, P < .0001), waist circumference (r = 0.474, P < .0001), glycemia (r = 0.300, P = .029), insulin (r = 0.628, P = .002), homeostatic model assessment index (r = 0.605, P = .005), triglycerides (r = 0.340, P = .011), total cholesterol (r = 0.346, P = .010), and low-density lipoprotein cholesterol (r = 0.334, P = .016). All relations, with the exception of glycemia, retained statistical significance after adjusting for age, smoking habit, and years since menopause (P < .0001 for body mass index, waist circumference, and triglycerides; P < .05 for all other associations). Analysis of covariance, after adjusting for confounders, showed that women with obesity or metabolic syndrome (MetS) showed significantly higher PI values (obesity: F = 17.79, P = .001; MetS: F = 7.37, P = .019). In particular, a stepwise increase of PI was found as a function of increasing MetS components (beta = 0.434, P = .007). Clitoral PI was negatively associated with Female Sexual Function Index arousal (beta = -0.321, P = .014) and satisfaction (beta = -0.289, P = .026) scores and positively associated with Middlesex Hospital Questionnaire somatized anxiety symptoms, even after adjusting for age, smoking habit, years since menopause, and current use of psychiatric medication (beta = 0.354, P = .011). A positive association also was observed between PI and the BUT positive symptom distress index (beta = 0.322, P = .039) and BUT for dislike of the womb, genitals, and breast (beta = 0.538, P < .0001; beta = 0.642, P < .0001; beta = 0.549, P < .0001, respectively). After introducing waist circumference as another covariate, the associations between clitoral PI and the BUT positive symptom distress index and BUT dislike of the womb, genitals, and breast retained statistical significance (P = .038 for positive symptom distress index; P < .0001 for dislike of womb, genitals, and breast).
   Conclusion: Clitoral vascular resistance is positively associated with MetS (in particular insulin resistance), decreased sexual arousal, body image concerns, and increased somatized anxiety symptoms. Further studies are needed to establish whether treatment of metabolic abnormalities might improve clitoral color Doppler ultrasound indices and sexual outcomes. Copyright (C) 2016, International Society for Sexual Medicine. Published by Elsevier Inc. All rights reserved.
C1 [Maseroli, Elisa; Fanni, Egidia; Cipriani, Sarah; Scavello, Irene; Maggi, Mario; Vignozzi, Linda] Univ Florence, Dept Expt Clin & Biomed Sci Mario Serio, Sexual Med & Androl Unit, Viale Pieraccini 6, I-50139 Florence, Italy.
   [Pampaloni, Francesca; Fambrini, Massimiliano] Univ Florence, Dept Expt Clin & Biomed Sci Mario Serio, Gynecol & Obstet Unit, Florence, Italy.
   [Battaglia, Cesare] Univ Bologna, Dept Gynecol & Pathophysiol Human Reprod, Bologna, Italy.
   [Mannucci, Edoardo] Univ Florence, Diabet Sect Geriatr Unit, Dept Crit Care, Florence, Italy.
   [Jannini, Emmanuele A.] Univ Roma Tor Vergata, Dept Syst Med, Rome, Italy.
   [Maggi, Mario; Vignozzi, Linda] Ist Nazl Biostrutture & Biosistemi, Rome, Italy.
C3 University of Florence; University of Florence; University of Bologna;
   University of Florence; University of Rome Tor Vergata
RP Vignozzi, L (corresponding author), Univ Florence, Dept Expt Clin & Biomed Sci Mario Serio, Sexual Med & Androl Unit, Viale Pieraccini 6, I-50139 Florence, Italy.
EM linda.vignozzi@unifi.it
RI Maseroli, Elisa/AAA-9745-2020; Cipriani, Sarah/ITV-7039-2023; Maggi,
   Mario/AAB-8284-2019; Mannucci, Edoardo/K-6749-2016; Fambrini,
   Massimiliano/K-5835-2016
OI MAGGI, Mario/0000-0003-3267-4221; Mannucci, Edoardo/0000-0001-9759-9408;
   Fambrini, Massimiliano/0000-0003-0461-6390; Vignozzi,
   Linda/0000-0003-0907-0630
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NR 79
TC 63
Z9 65
U1 0
U2 13
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1743-6095
EI 1743-6109
J9 J SEX MED
JI J. Sex. Med.
PD NOV
PY 2016
VL 13
IS 11
BP 1651
EP 1661
DI 10.1016/j.jsxm.2016.09.009
PG 11
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA ED7LZ
UT WOS:000389048200005
PM 27692844
DA 2025-06-11
ER

PT J
AU Zheng, SY
   Wang, ZY
   Yang, LM
   Zhang, XY
AF Zheng, Siyang
   Wang, Zhiyang
   Yang, Limin
   Zhang, Xiangyang
TI Clinical correlates and thyroid hormones of metabolic syndrome in
   first-episode and drug-naïve major depressive disorder outpatients with
   and without hyperglycemia: a comprehensive cross-sectional study
SO BMC PSYCHIATRY
LA English
DT Article
DE Major depressive disorder; Hyperglycemia; Metabolic syndrome;
   Anti-thyroglobulin; Thyroid-stimulating hormone
ID SEX-DIFFERENCES; SUICIDE ATTEMPTS; ASSOCIATION; METAANALYSIS; RISK;
   PREVALENCE; AGE; GUIDELINES; SEROTONIN; DISEASES
AB Hyperglycemia and metabolic syndrome (MetS) are common in patients with major depressive disorder (MDD). This study aimed to explore the prevalence and clinical factors of MetS in first-episode and drug-naive MDD (FEDND) patients with and without hyperglycemia. A total of 1,718 FEDND patients' symptoms were assessed using the Hamilton Depression Scale (HAMD), Hamilton Anxiety Scale (HAMA), and positive subscale of the Positive and Negative Syndrome Scale (PANSS). Blood glucose levels, metabolic index, and thyroid hormones were measured during fasting. The prevalence of MetS in FEDND patients with hyperglycemia was 35.67 times higher than in FEDND patients without hyperglycemia. FEDND patients with MetS were older, had later age of onset, and were predominantly married than those without MetS (p < 0.05). Among FEDND patients without hyperglycemia, suicide attempts, severe anxiety, HAMD, HAMA, PANSS subscale scores, thyroid stimulating hormone, antithyroglobulin, and total cholesterol levels were all higher in patients with MetS than those without MetS (all p < 0.05). In FEDND patients without hyperglycemia, the combination of age and TgAb distinguished those patients with and without MetS. Our results suggest a high prevalence of MetS in FEDND patients with hyperglycemia. Several clinical variables and thyroid function-related hormones impact MetS in patients with FEDND.
C1 [Zheng, Siyang; Wang, Zhiyang] Dalian Med Univ, Coll Basic Med Sci, Dalian 116044, Peoples R China.
   [Yang, Limin] Dalian Univ, Sch Med, Dalian 116622, Liaoning, Peoples R China.
   [Zhang, Xiangyang] Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing 100101, Peoples R China.
C3 Dalian Medical University; Dalian University; Chinese Academy of
   Sciences; Institute of Psychology, CAS
RP Yang, LM (corresponding author), Dalian Univ, Sch Med, Dalian 116622, Liaoning, Peoples R China.; Zhang, XY (corresponding author), Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing 100101, Peoples R China.
EM yanglimin@dlu.edu.cn; zhangxy@psych.ac.cn
RI Zhang, Xiangyang/ABC-7380-2022
OI Zhang, Xiangyang/0000-0003-3326-382X
FU Thanks to the First Clinical Medical College and Shanxi Medical
   University for their support. Thanks to Dr. Li Mu for her advice in data
   analysis and writing. We want to extend our sincere appreciation to
   everyone who contributed to this work.; Shanxi Medical University
FX Thanks to the First Clinical Medical College and Shanxi Medical
   University for their support. Thanks to Dr. Li Mu for her advice in data
   analysis and writing. We want to extend our sincere appreciation to
   everyone who contributed to this work.
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NR 55
TC 2
Z9 2
U1 1
U2 1
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-244X
J9 BMC PSYCHIATRY
JI BMC Psychiatry
PD SEP 4
PY 2023
VL 23
IS 1
AR 649
DI 10.1186/s12888-023-05150-8
PG 8
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychiatry
GA R0PA5
UT WOS:001061436300008
PM 37667222
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Jullian-Desayes, I
   Joyeux-Faure, M
   Tamisier, R
   Launois, S
   Borel, AL
   Levy, P
   Pepin, JL
AF Jullian-Desayes, Ingrid
   Joyeux-Faure, Marie
   Tamisier, Renaud
   Launois, Sandrine
   Borel, Anne-Laure
   Levy, Patrick
   Pepin, Jean-Louis
TI Impact of obstructive sleep apnea treatment by continuous positive
   airway pressure on cardiometabolic biomarkers: A systematic review from
   sham CPAP randomized controlled trials
SO SLEEP MEDICINE REVIEWS
LA English
DT Review
DE Obstructive sleep apnea; Cardiometabolic biomarkers; Continuous positive
   airway pressure; Randomized controlled trial
ID ENDOTHELIAL PROGENITOR CELLS; FATTY LIVER-DISEASE; PLACEBO-CONTROLLED
   CROSSOVER; SERUM AMINOTRANSFERASE LEVELS; CHRONIC INTERMITTENT HYPOXIA;
   C-REACTIVE PROTEIN; OXIDATIVE STRESS; INSULIN-RESISTANCE; METABOLIC
   SYNDROME; CARDIOVASCULAR RISK
AB Reducing cardiometabolic risk may represent an important target for effective obstructive sleep apnea (OSA) treatment. The impact of continuous positive airway pressure (CPAP), the first line therapy of OSA, on metabolic or inflammatory markers is still debated. A systematic literature search using several data-bases was performed. We provide a systematic analysis of randomized studies comparing therapeutic versus sham CPAP intervention and also include studies using a CPAP withdrawal design. We addressed the impact of CPAP on the following cardiometabolic biomarkers: 1) plasma and urine catecholamines and their metabolites that reflect sympathetic activity; 2) insulin resistance and lipid metabolism biomarkers; 3) oxidative stress, systemic and vascular inflammation biomarkers; 4) liver enzymes highlighting the association between OSA and nonalcoholic fatty liver disease (NAFLD); 5) coagulation biomarkers. The impact of CPAP on sympathetic activity is robust across studies and occurs rapidly. In contrast to sympathetic activity, the well-designed studies included in this review failed to demonstrate that CPAP alters metabolic or inflammatory markers in OSA. CPAP did not change glucose, lipids, insulin resistance levels or the ratio of patients with metabolic syndrome. In unselected OSA patients, it is not realistic to expect a clinically relevant decrease in cardiometabolic biomarkers with CPAP therapy. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Jullian-Desayes, Ingrid; Joyeux-Faure, Marie; Tamisier, Renaud; Launois, Sandrine; Borel, Anne-Laure; Levy, Patrick; Pepin, Jean-Louis] Univ Grenoble Alpes, INSERM, HP2, U1042, Grenoble, France.
   [Jullian-Desayes, Ingrid; Joyeux-Faure, Marie; Tamisier, Renaud; Launois, Sandrine; Levy, Patrick; Pepin, Jean-Louis] CHU Grenoble, Lab EFCR, Secteur Physiol Sommeil & Exercice, F-38043 Grenoble, France.
   CHU Grenoble, Malad Nutr, Dept Endocrinol Diabetol, F-38043 Grenoble, France.
C3 Institut National de la Sante et de la Recherche Medicale (Inserm);
   Communaute Universite Grenoble Alpes; Universite Grenoble Alpes (UGA);
   Communaute Universite Grenoble Alpes; Universite Grenoble Alpes (UGA);
   CHU Grenoble Alpes; Communaute Universite Grenoble Alpes; Universite
   Grenoble Alpes (UGA); CHU Grenoble Alpes
RP Pepin, JL (corresponding author), CHU Grenoble, Lab EFCR, CS 10 217, F-38043 Grenoble 9, France.
EM JPepin@chu-grenoble.fr
RI Launois, Sandrine/M-6941-2014; Borel, Anne-Laure/M-7117-2014; JOYEUX,
   Marie/M-7330-2014; PEPIN, Jean-Louis/M-6549-2014; Tamisier,
   Renaud/M-6858-2014; LEVY, Patrick/AAX-2802-2020
OI Levy, Patrick/0000-0003-3174-7935; Pepin, Jean
   Louis/0000-0003-3832-2358; Borel, Anne-Laure/0000-0002-7368-172X;
   JOYEUX-FAURE, Marie/0000-0001-8298-0038
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NR 100
TC 151
Z9 157
U1 0
U2 29
PU W B SAUNDERS CO LTD
PI LONDON
PA 32 JAMESTOWN RD, LONDON NW1 7BY, ENGLAND
SN 1087-0792
EI 1532-2955
J9 SLEEP MED REV
JI Sleep Med. Rev.
PD JUN
PY 2015
VL 21
BP 23
EP 38
DI 10.1016/j.smrv.2014.07.004
PG 16
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA CH6OV
UT WOS:000354156800004
PM 25220580
DA 2025-06-11
ER

PT J
AU Ashrafian, H
   Ahmed, K
   Rowland, SP
   Patel, VM
   Gooderham, NJ
   Holmes, E
   Darzi, A
   Athanasiou, T
AF Ashrafian, Hutan
   Ahmed, Kamran
   Rowland, Simon P.
   Patel, Vanash M.
   Gooderham, Nigel J.
   Holmes, Elaine
   Darzi, Ara
   Athanasiou, Thanos
TI Metabolic Surgery and Cancer Protective Effects of Bariatric Procedures
SO CANCER
LA English
DT Review
DE metabolic surgery; bariatric surgery; cancer; oncology
ID GASTRIC-BYPASS-SURGERY; INTENTIONAL WEIGHT-LOSS; MORBIDLY
   OBESE-PATIENTS; BODY-MASS INDEX; LONG-TERM MORTALITY; INSULIN-RESISTANCE
   SYNDROME; TYPE-2 DIABETES-MELLITUS; QUALITY-OF-LIFE; ENERGY-EXPENDITURE;
   BREAST-CANCER
AB The worldwide epidemic of obesity and the global incidence of cancer are both increasing. There is now epidemiological evidence to support a correlation between obesity, weight gain, and some cancers. Metabolic or bariatric surgery can provide sustained weight loss and reduced obesity-related mortality. These procedures can also improve the metabolic profile to decrease cardiovascular risk and resolve diabetes in morbidly obese patients. The operations offer several physiological steps, the so-called BRAVE effects: 1) bile flow alteration, 2) reduction of gastric size, 3) anatomical gut rearrangement and altered flow of nutrients, 4) vagal manipulation and 5) enteric gut hormone modulation. Metabolic operations are also associated with a significant reduction of cancer incidence and mortality. The cancer-protective role of metabolic surgery is strongest for female obesity-related tumors; however, the underlying mechanisms may involve both weight-dependent and weight-independent effects. These include the improvement of insulin resistance with attenuation of the metabolic syndrome as well as decreased oxidative stress and inflammation in addition to the beneficial modulation of sex steroids, gut hormones, cellular energetics, immune system, and adipokines. Elucidating the precise metabolic mechanisms of cancer prevention by metabolic surgery can increase our understanding of how obesity, diabetes, and metabolic syndrome are associated with cancer. It may also offer novel treatment strategies in the management of tumor generation and growth. Cancer 2011;117:1788-99. (C) 2010 American Cancer Society.
C1 [Ashrafian, Hutan; Ahmed, Kamran; Rowland, Simon P.; Patel, Vanash M.; Gooderham, Nigel J.; Holmes, Elaine; Darzi, Ara; Athanasiou, Thanos] Univ London Imperial Coll Sci Technol & Med, Dept Surg & Canc, London W2 1NY, England.
C3 Imperial College London
RP Ashrafian, H (corresponding author), Univ London Imperial Coll Sci Technol & Med, Dept Surg & Canc, 10th Floor QEQM Bldg,Praed St, London W2 1NY, England.
EM h.ashrafian@imperial.ac.uk
RI Ahmed, Kamran/B-1528-2010; Holmes, Elaine/ABE-6606-2020
OI Holmes, Elaine/0000-0002-0556-8389; Ahmed, Kamran/0000-0002-5135-9211;
   Ashrafian, Hutan/0000-0003-1668-0672; Gooderham,
   Nigel/0000-0001-7645-8219
FU Wellcome Trust; NIHR Biomedical Research Centre
FX The Wellcome Trust and the NIHR Biomedical Research Centre Funding
   Scheme supported this study.
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NR 117
TC 109
Z9 120
U1 0
U2 15
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0008-543X
EI 1097-0142
J9 CANCER-AM CANCER SOC
JI Cancer
PD MAY 1
PY 2011
VL 117
IS 9
BP 1788
EP 1799
DI 10.1002/cncr.25738
PG 12
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA 754DQ
UT WOS:000289833100004
PM 21509756
OA Bronze
DA 2025-06-11
ER

PT J
AU Farkas, GJ
   Sneij, A
   Gater, DR
AF Farkas, Gary J.
   Sneij, Alicia
   Gater, David R., Jr.
TI Dietetics After Spinal Cord Injury: Current Evidence and Future
   Perspectives
SO TOPICS IN SPINAL CORD INJURY REHABILITATION
LA English
DT Article
DE caloric intake calories; carbohydrates; dietary intake; fat;
   macronutrients; micronutrients; nutrition; protein; spinal cord injury
ID CLINICAL-PRACTICE GUIDELINE; C-REACTIVE PROTEIN; METABOLIC SYNDROME;
   RISK-FACTORS; ENERGY-EXPENDITURE; NUTRITIONAL ASSESSMENT;
   CARDIOMETABOLIC RISK; PHYSICAL-ACTIVITY; LIPID-METABOLISM;
   BODY-COMPOSITION
AB Following spinal cord injury (SCI), individuals are at high risk for obesity and several chronic cardiometabolic disorders due to a deterioration in body composition, hypometabolic rate, and endometabolic dysregulation. Countermeasures to the consequences of an SCI include adopting a healthy diet that provides adequate nutrition to maintain good body habitus and cardiometabolic health. A proper diet for individuals with SCI should distribute carbohydrates, protein, and fat to optimize a lower energy intake requirement and should stress foods with low caloric yet high nutrient density. The purpose of this article is to present available evidence on how nutritional status after SCI should advance future research to further develop SCIspecific guidelines for total energy intake, as it relates to percent carbohydrates, protein, fat, and all vitamins and minerals, that take into consideration the adaptations after SCI.
C1 [Farkas, Gary J.; Sneij, Alicia; Gater, David R., Jr.] Univ Miami, Dept Phys Med & Rehabil, Miller Sch Med, 1611 NW 12th Ave, Miami, FL 33136 USA.
   [Gater, David R., Jr.] Univ Miami, Miami Project Cure Paralysis, Miller Sch Med, Miami, FL 33136 USA.
C3 University of Miami; University of Miami
RP Farkas, GJ (corresponding author), Univ Miami, Dept Phys Med & Rehabil, Miller Sch Med, 1611 NW 12th Ave, Miami, FL 33136 USA.
EM gjf50@med.miami.edu
RI Farkas, Gary/AAC-5917-2021
OI Farkas, Gary J/0000-0002-5482-6049
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NR 96
TC 20
Z9 20
U1 0
U2 5
PU AMER SPINAL INJURY ASSOC
PI RICHMOND
PA 9702 GAYTON RD, SUITE 306, RICHMOND, VA, UNITED STATES
SN 1082-0744
EI 1945-5763
J9 TOP SPINAL CORD INJ
JI Top. Spinal Cord Inj. Rehabil.
PY 2021
VL 27
IS 1
SI SI
BP 100
EP 108
DI 10.46292/sci20-00031
PG 9
WC Rehabilitation
WE Emerging Sources Citation Index (ESCI)
SC Rehabilitation
GA SG9RC
UT WOS:000653776200010
PM 33814888
DA 2025-06-11
ER

PT J
AU Patel, V
   Menezes, H
   Menezes, C
   Bouwer, S
   Bostick-Smith, CA
   Speelman, DL
AF Patel, Vishesha
   Menezes, Heather
   Menezes, Christian
   Bouwer, Stephanie
   Bostick-Smith, Chevelta A.
   Speelman, Diana L.
TI Regular Mindful Yoga Practice as a Method to Improve Androgen Levels in
   Women With Polycystic Ovary Syndrome: A Randomized, Controlled Trial
SO JOURNAL OF THE AMERICAN OSTEOPATHIC ASSOCIATION
LA English
DT Article
DE anxiety; depression; exercise; holistic; hyperandrogenism; testosterone
ID INSULIN-RESISTANCE; METABOLIC SYNDROME; STRESS REDUCTION; OBESITY; PCOS;
   ADIPONECTIN; UTILITY; HYPERANDROGENISM; DEPRESSION; MANAGEMENT
AB Background: Holistic approaches are needed to complement existing therapies for polycystic ovary syndrome (PCOS), a common disorder affecting the health of reproductive-aged females.
   Objective: To determine whether thrice-weekly mindful yoga practice improves endocrine, cardiometabolic, or psychological parameters in women with PCOS.
   Methods: Thirty-one women with PCOS between the ages of 23 and 42 years and living in Erie County, Pennsylvania, were recruited for this randomized, controlled study arm, which was part of a larger 3-part investigation. Women were randomly assigned to either a mindful yoga intervention group or no intervention (control) group. Group classes were 1 hour, thrice weekly. Initial endocrine, cardiometabolic, and psychological measurements were compared with measurements taken after the 3-month intervention period. Measurements included free testosterone, dehydroepiandrosterone, androstenedione, body mass index, waist-to-hip ratio, fasting blood glucose and insulin levels, and anxiety and depression scores.
   Results: Twenty-two women completed the 3-month intervention period, 13 in the mindful yoga group and 9 in the control group. Paired comparisons of pre- and post-intervention parameters indicated that women who completed the mindful yoga intervention had significantly lower free testosterone levels (5.96 vs 4.24 pg/mL; P<.05) and dehydroepiandrosterone levels that trended lower. Improved testosterone may persist for several months after completion of a 3-month, thrice-weekly mindful yoga intervention. Additionally, improvements were seen in measures of anxiety and depression.
   Conclusion: The improvements observed suggest that regular mindful yoga practice can be a useful complementary therapeutic option for women with PCOS, particularly for improving serum androgen levels, a hallmark feature of PCOS. This improvement occurred in the absence of weight loss and may persist even if there is a lapse in practice.
C1 [Patel, Vishesha; Menezes, Heather; Menezes, Christian; Bouwer, Stephanie; Bostick-Smith, Chevelta A.; Speelman, Diana L.] Lake Erie Coll Osteopath Med, Dept Biochem, Erie, PA 16509 USA.
RP Speelman, DL (corresponding author), Lake Erie Coll Osteopath Med, 2000 W Grandview Blvd, Erie, PA 16509 USA.
EM dspeelman@lecom.edu
FU AOA [181627705]
FX This work was funded by AOA Grant No. 181627705 to Diana Speelman, PhD.
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NR 61
TC 20
Z9 21
U1 3
U2 13
PU AMER OSTEOPATHIC ASSN
PI CHICAGO
PA 142 EAST ONTARIO STREET, CHICAGO, IL 60611-2864 USA
SN 0098-6151
EI 1945-1997
J9 J AM OSTEOPATH ASSOC
JI J. Am. Osteopath. Assoc.
PD MAY
PY 2020
VL 120
IS 5
BP 323
EP 335
DI 10.7556/jaoa.2020.050
PG 13
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA LT0OF
UT WOS:000536775600005
PM 32285088
OA Bronze
DA 2025-06-11
ER

PT J
AU Kim, IS
   Hwang, JY
AF Kim, In Seon
   Hwang, Ji-Yun
TI Does Better Diet Quality Offset the Association between Depression and
   Metabolic Syndrome?
SO NUTRIENTS
LA English
DT Article
DE depression; diet quality; metabolic syndrome; PHQ-9; healthy eating
   index
ID NATIONAL-HEALTH; VEGETABLE CONSUMPTION; MEDITERRANEAN DIET; RISK;
   METAANALYSIS; SYMPTOMS; OBESITY; FRUIT; DISORDER; ADULTS
AB Several studies have shown that depression increases the risk of metabolic syndrome (MetS), which is often exacerbated by the fact that both exist concurrently. People with depression are more likely to have unhealthy eating habits, which can eventually trigger the development of MetS. This study was to investigate whether diet quality modifies the association between depression and MetS in a total of 13,539 Korean adults aged 19 to 80 from 2014, 2016 and 2018 Korean National Health and Nutrition Examination Surveys. Depression was assessed by the Patient Health Questionnaire-9 (PHQ-9) and subjects were divided into subgroups according to the PHQ-9 scores: normal (<5), mild (5-9), and moderate-to-severe (>= 10) groups. Diet quality was measured by the Korean Healthy Eating Index (KHEI). A complex sample multiple logistic regression stratified by tertiles of KHEI scores was used to explore whether diet quality modifies an association between depression severity and metabolic syndrome. Depression severity was positively associated with the risk of MetS (p trend = 0.006) after adjustment for potential confounders. Only the lowest diet quality, moderately-to-severely depressed group, showed a higher risk of MetS (OR: 1.72, 95% CI: 1.24-2.40) compared to the normal group. Our results suggest that healthy diet quality could offset the positive relationship between depression and MetS in the general Korean adult population. Encouraging a healthy diet regime can improve not only physical health but also the mental state of the general public.
C1 [Kim, In Seon] Sangmyung Univ, Grad Sch, Dept Foodserv Management & Nutr, Seoul 03016, South Korea.
   [Hwang, Ji-Yun] Sangmyung Univ, Major Foodserv Management & Nutr, Seoul 03016, South Korea.
C3 Sangmyung University; Sangmyung University
RP Hwang, JY (corresponding author), Sangmyung Univ, Major Foodserv Management & Nutr, Seoul 03016, South Korea.
EM jiyunhk@smu.ac.kr
RI Kim, Mi-Jeong/AAK-3053-2021
OI Hwang, Ji-Yun/0000-0003-4003-1293
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NR 72
TC 1
Z9 1
U1 1
U2 11
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD FEB
PY 2023
VL 15
IS 4
AR 1060
DI 10.3390/nu15041060
PG 17
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 9K7HI
UT WOS:000941034100001
PM 36839420
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Zeugmann, S
   Buehrsch, N
   Bajbouj, M
   Heuser, I
   Anghelescu, I
   Quante, A
AF Zeugmann, Sara
   Buehrsch, Nicole
   Bajbouj, Malek
   Heuser, Isabella
   Anghelescu, Ion
   Quante, Arnim
TI CHILDHOOD MALTREATMENT AND ADULT PROINFLAMMATORY STATUS IN PATIENTS WITH
   MAJOR DEPRESSION
SO PSYCHIATRIA DANUBINA
LA English
DT Article
DE childhood maltreatment; major depression; subclinical inflammation
ID EARLY-LIFE STRESS; GUINEA-PIG PUPS; INFLAMMATORY RESPONSES; MATERNAL
   SEPARATION; MALADAPTIVE SCHEMAS; METABOLIC SYNDROME; IMMUNE-RESPONSE;
   HEART-DISEASE; FIBRINOGEN; ASSOCIATION
AB Background: An increasing body of research considers the immunological effects of major depression. It remains an open question, whether depression itself acts in an immunomodulatory fashion or whether other factors related to depression result in these immunological effects. Regardless, major depression is often the result of early life stress, the implications of which are not satisfactorily understood.
   Subjects and methods: Early life stress was retrospectively evaluated in 25 depressed inpatients via the CTQ (Childhood Trauma Questionnaire). Its impact on immunological biomarkers (fibrinogen, SAA, CRP, adiponectin, TNF-alpha, resistin, and sE-selectin) in adulthood was assessed via multiple regression analyses. Parental bonding was assessed via the PBI (Parental bonding questionnaire), severity of depression with the HDRS-17 (Hamilton-Depression-Rating Scale).
   Results: Nearly all patients had experienced a parental style of affectionless control. Physical neglect significantly predicted fibrinogen levels (R-2=0.42, adjusted R-2=0.27, beta=0.56, p=0.04). Severity of depression was not associated with immune markers.
   Conclusion: Childhood maltreatment was linked to fibrinogen levels in our sample. Thus, inflammation may be an important mechanism mediating the adverse effects of early life stress on adult health in patients with major depression.
C1 [Zeugmann, Sara; Buehrsch, Nicole; Bajbouj, Malek; Heuser, Isabella; Anghelescu, Ion; Quante, Arnim] Charite, Dept Psychiat & Psychotherapy, D-13353 Berlin, Germany.
C3 Berlin Institute of Health; Free University of Berlin; Humboldt
   University of Berlin; Charite Universitatsmedizin Berlin
RP Zeugmann, S (corresponding author), Charite, Dept Psychiat & Psychotherapy, Campus Benjamin Franklin, D-13353 Berlin, Germany.
EM sara.zeugmann@charite.de
RI Bajbouj, Malek/B-3579-2012
OI Heuser, Isabella/0000-0001-7075-1158; Bajbouj, Malek/0000-0002-0073-3322
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NR 53
TC 30
Z9 31
U1 0
U2 13
PU MEDICINSKA NAKLADA
PI ZAGREB
PA VLASKA 69, HR-10000 ZAGREB, CROATIA
SN 0353-5053
J9 PSYCHIAT DANUB
JI Psychiatr. Danub.
PY 2013
VL 25
IS 3
BP 227
EP 235
PG 9
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA AK7TG
UT WOS:000338630000005
PM 24048389
DA 2025-06-11
ER

PT J
AU Pignotti, GAP
   Hook, G
   Ghan, E
   Vega-López, S
AF Pignotti, G. A. P.
   Hook, G.
   Ghan, E.
   Vega-Lopez, S.
TI Effect of nopales (Opuntia spp.) on lipoprotein profile
   and oxidative stress among moderately hypercholesterolemic adults: A
   pilot study
SO JOURNAL OF FUNCTIONAL FOODS
LA English
DT Article
DE Nopales; Functional food; Lipoprotein profile; Cardiometabolic risk;
   Oxidative stress
ID LOW-DENSITY-LIPOPROTEIN; FICUS-INDICA; SERUM-LIPIDS; ANTIOXIDANT
   ACTIVITY; OXIDIZED LDL; CHOLESTEROL; CONSUMPTION; METAANALYSIS;
   BREAKFASTS; ROBUSTA
AB This study evaluated the effect of nopales (prickly pear cactus pads) for improving cardiometabolic risk factors and oxidative stress, compared to control, in hypercholesterolemic adults. In a randomized crossover trial, participants were assigned to a 2-wk intervention with 2 cups/day of nopales or cucumbers (control), with a 2 to 3-wk washout period. The study included 16 adults (46 +/- 14 y; BMI = 31.4 +/- 5.7 kg/m(2)) with moderate hypercholesterolemia. There was no significant treatment-by-time effect for any dietary composition data, lipid profile, cardiometabolic outcomes, or oxidative stress markers. Both treatments significantly increased triglyceride concentrations (cucumber, 14.8%; nopales, 15.2%; p(Time) = 0.020). On average, LDL-c was decreased by 2.0 mg/dL (-1.4%) after the cucumber phase and 3.9 mg/dL (-2.9%) after the nopales phase (p(Time) = 0.176). In conclusion, these data do not support the purported benefits of nopales at doses of 2 cups/day for 2-wk on markers of lipoprotein profile, cardiometabolic risk, and oxidative stress in hypercholesterolemic adults. Published by Elsevier Ltd.
C1 [Pignotti, G. A. P.; Hook, G.; Ghan, E.; Vega-Lopez, S.] Arizona State Univ, Sch Nutr & Hlth Promot, 500 North 3rd St, Phoenix, AZ 85004 USA.
   [Pignotti, G. A. P.] San Jose State Univ, Dept Nutr Food Sci & Packaging, One Washington Sq, San Jose, CA 95192 USA.
C3 Arizona State University; Arizona State University-Downtown Phoenix;
   California State University System; San Jose State University
RP Vega-López, S (corresponding author), Arizona State Univ, Sch Nutr & Hlth Promot, 500 North 3rd St, Phoenix, AZ 85004 USA.
EM sonia.vega.lopez@asu.edu
RI Pignotti, Giselle/E-5237-2013
OI Pereira Pignotti, Giselle/0000-0002-1413-7062
FU Arizona Board of Regents (ABOR) Doctoral Research Grant; Arizona State
   University Graduate Research Support Program Grant
FX The authors want to thank study participants for their contributions to
   this study. Data were collected with support from the Arizona Board of
   Regents (ABOR) Doctoral Research Grant and Arizona State University
   Graduate Research Support Program Grant. The funding sources had no
   involvement in the study design, data collection, analysis and
   interpretation, writing of the report, and decision to submit the
   article for publication.
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NR 33
TC 4
Z9 4
U1 0
U2 17
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1756-4646
J9 J FUNCT FOODS
JI J. Funct. Food.
PD DEC
PY 2016
VL 27
BP 115
EP 121
DI 10.1016/j.jff.2016.08.060
PG 7
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA EF2UB
UT WOS:000390180000010
DA 2025-06-11
ER

PT J
AU Wong, WLE
   Arathimos, R
   Lewis, CM
   Young, AH
   Dawe, GS
AF Wong, Win Lee Edwin
   Arathimos, Ryan
   Lewis, Cathryn M.
   Young, Allan H.
   Dawe, Gavin S.
TI Investigating the role of the relaxin-3/RXFP3 system in neuropsychiatric
   disorders and metabolic phenotypes: A candidate gene approach
SO PLOS ONE
LA English
DT Article
ID CORTICOTROPIN-RELEASING-FACTOR; ANXIETY; DEPRESSION; RELAXIN; RECEPTORS;
   DIAGNOSIS; BRAIN; PHQ-9
AB The relaxin-3/RXFP3 system has been implicated in the modulation of depressive- and anxiety-like behaviour in the animal literature; however, there is a lack of human studies investigating this signalling system. We seek to bridge this gap by leveraging the large UK Biobank study to retrospectively assess genetic risk variants linked with this neuropeptidergic system. Specifically, we conducted a candidate gene study in the UK Biobank to test for potential associations between a set of functional, candidate single nucleotide polymorphisms (SNPs) pertinent to relaxin-3 signalling, determined using in silico tools, and several outcomes, including depression, atypical depression, anxiety and metabolic syndrome. For each outcome, we used several rigorously defined phenotypes, culminating in subsample sizes ranging from 85,881 to 386,769 participants. Across all outcomes, there were no associations between any candidate SNP and any outcome phenotype, following corrections for multiple testing burden. Regression models comprising several SNPs per relevant candidate gene as exploratory variables further exhibited no prediction of outcome. Our findings corroborate conclusions from previous literature about the limitations of candidate gene approaches, even when based on firm biological hypotheses, in the domain of genetic research for neuropsychiatric disorders.
C1 [Wong, Win Lee Edwin; Dawe, Gavin S.] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Pharmacol, Singapore, Singapore.
   [Wong, Win Lee Edwin; Dawe, Gavin S.] Natl Univ Singapore, Yong Loo Lin Sch Med, Hlth Longev Translat Res Programme, Singapore, Singapore.
   [Wong, Win Lee Edwin; Young, Allan H.] Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Psychol Med, London, England.
   [Arathimos, Ryan; Lewis, Cathryn M.] Kings Coll London, Inst Psychiat Psychol & Neurosci, Social Genet & Dev Psychiat Ctr, London, England.
   [Lewis, Cathryn M.] Kings Coll London, Fac Life Sci & Med, Dept Med & Mol Genet, London, England.
   [Young, Allan H.] South London & Maudsley NHS Fdn Trust, Bethlem Royal Hosp, London, England.
   [Dawe, Gavin S.] Natl Univ Singapore, Life Sci Inst, Neurobiol Programme, Singapore, Singapore.
C3 National University of Singapore; National University of Singapore;
   University of London; King's College London; University of London;
   King's College London; University of London; King's College London;
   South London & Maudsley NHS Trust; Bethlem Royal Hospital; National
   University of Singapore
RP Wong, WLE (corresponding author), Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Pharmacol, Singapore, Singapore.; Wong, WLE (corresponding author), Natl Univ Singapore, Yong Loo Lin Sch Med, Hlth Longev Translat Res Programme, Singapore, Singapore.; Wong, WLE (corresponding author), Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Psychol Med, London, England.
EM win_lee_edwin.wong@kcl.ac.uk
RI Madni, Ghulam/AAM-7738-2021; Lewis, Cathryn/M-8766-2019; Lewis,
   Cathryn/A-5225-2010
OI Lewis, Cathryn/0000-0002-8249-8476; Dawe, Gavin/0000-0001-6119-701X;
   Arathimos, Ryan/0000-0002-0473-500X; Young, Allan/0000-0003-2291-6952;
   Wong, Win Lee Edwin/0000-0001-6905-6449
FU National Institute for Health and Care Research (NIHR) Maudsley
   Biomedical Research Centre at South London and Maudsley NHS Foundation
   Trust and King's College London [16577]
FX The views expressed are those of the author(s) and not necessarily those
   of the NHS, the NIHR or the Department of Health and Social Care. This
   research has been conducted using the UK Biobank Resource under
   Application Number 16577. The authors wish to thank Jonathan R. I.
   Coleman and Gerome Breen for their valuable contributions in support of
   this study. In addition, we are grateful to all UK Biobank staff and
   volunteers. Finally, the authors acknowledge use of the research
   computing facility at King's College London, Rosalind
   (https://rosalind.kcl.ac.uk).
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NR 57
TC 0
Z9 0
U1 0
U2 5
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
EI 1932-6203
J9 PLOS ONE
JI PLoS One
PD NOV 15
PY 2023
VL 18
IS 11
AR e0294045
DI 10.1371/journal.pone.0294045
PG 19
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA CI0N0
UT WOS:001124507100050
PM 37967073
OA Green Submitted, gold, Green Published
DA 2025-06-11
ER

PT J
AU Gutiérrez-Esparza, G
   Martinez-Garcia, M
   Ramírez-delReal, T
   Groves-Miralrio, LE
   Marquez, MF
   Pulido, T
   Amezcua-Guerra, LM
   Hernández-Lemus, E
AF Gutierrez-Esparza, Guadalupe
   Martinez-Garcia, Mireya
   Ramirez-delReal, Tania
   Groves-Miralrio, Lucero Elizabeth
   Marquez, Manlio F.
   Pulido, Tomas
   Amezcua-Guerra, Luis M.
   Hernandez-Lemus, Enrique
TI Sleep Quality, Nutrient Intake, and Social Development Index Predict
   Metabolic Syndrome in the Tlalpan 2020 Cohort: A Machine Learning and
   Synthetic Data Study
SO NUTRIENTS
LA English
DT Article
DE poor quality sleep; social development index; nutrients; machine
   learning; features selection; balancing methods; Mexico City; Tlalpan
   2020 cohort
ID MEDICAL OUTCOMES; ASSOCIATION; HEALTH; PREVALENCE; ANXIETY; RISK;
   RELIABILITY; POPULATION; PREVENTION; DEPRESSION
AB This study investigated the relationship between Metabolic Syndrome (MetS), sleep disorders, the consumption of some nutrients, and social development factors, focusing on gender differences in an unbalanced dataset from a Mexico City cohort. We used data balancing techniques like SMOTE and ADASYN after employing machine learning models like random forest and RPART to predict MetS. Random forest excelled, achieving significant, balanced accuracy, indicating its robustness in predicting MetS and achieving a balanced accuracy of approximately 87%. Key predictors for men included body mass index and family history of gout, while waist circumference and glucose levels were most significant for women. In relation to diet, sleep quality, and social development, metabolic syndrome in men was associated with high lactose and carbohydrate intake, educational lag, living with a partner without marrying, and lack of durable goods, whereas in women, best predictors in these dimensions include protein, fructose, and cholesterol intake, copper metabolites, snoring, sobbing, drowsiness, sanitary adequacy, and anxiety. These findings underscore the need for personalized approaches in managing MetS and point to a promising direction for future research into the interplay between social factors, sleep disorders, and metabolic health, which mainly depend on nutrient consumption by region.
C1 [Gutierrez-Esparza, Guadalupe] Natl Council Humanities Sci & Technol, Mexico CONAHCYT, Mexico City 08400, Mexico.
   [Gutierrez-Esparza, Guadalupe] Natl Inst Cardiol Ignacio Chavez, Clin Res, Mexico City 14080, Mexico.
   [Martinez-Garcia, Mireya; Groves-Miralrio, Lucero Elizabeth; Amezcua-Guerra, Luis M.] Natl Inst Cardiol Ignacio Chavez, Dept Immunol, Mexico City 14080, Mexico.
   [Ramirez-delReal, Tania] Ctr Res Geospatial Informat Sci, Aguascalientes 20313, Mexico.
   [Marquez, Manlio F.] Natl Inst Cardiol Ignacio Chavez, Dept Electrocardiol, Mexico City 14080, Mexico.
   [Pulido, Tomas] Natl Inst Cardiol Ignacio Chavez, Cardiopulm Dept, Mexico City 14080, Mexico.
   [Hernandez-Lemus, Enrique] Natl Inst Genom Med, Computat Genom Div, Mexico City 14610, Mexico.
   [Hernandez-Lemus, Enrique] Univ Nacl Autonoma Mexico, Ctr Complex Sci, Mexico City 04510, Mexico.
C3 National Institute of Cardiology - Mexico; National Institute of
   Cardiology - Mexico; National Institute of Cardiology - Mexico; National
   Institute of Cardiology - Mexico; Instituto Nacional de Medicina
   Genomica; Universidad Nacional Autonoma de Mexico
RP Gutiérrez-Esparza, G (corresponding author), Natl Council Humanities Sci & Technol, Mexico CONAHCYT, Mexico City 08400, Mexico.; Gutiérrez-Esparza, G (corresponding author), Natl Inst Cardiol Ignacio Chavez, Clin Res, Mexico City 14080, Mexico.; Hernández-Lemus, E (corresponding author), Natl Inst Genom Med, Computat Genom Div, Mexico City 14610, Mexico.; Hernández-Lemus, E (corresponding author), Univ Nacl Autonoma Mexico, Ctr Complex Sci, Mexico City 04510, Mexico.
EM ggutierreze@conacyt.mx; mireya.martinez@cardiologia.org.mx;
   tramirez@centrogeo.edu.mx; tomas.pulido@cardiologia.org.mx;
   lmamezcuag@gmail.com; ehernandez@inmegen.gob.mx
RI Amezcua-Guerra, Luis/AAH-7127-2020; Martínez-García,
   Mireya/AAU-6797-2020; Ramirez-delReal, Tania Aglae/ISS-4817-2023
OI Hernandez-Lemus, Enrique/0000-0002-1872-1397; Martinez-Garcia,
   Mireya/0000-0002-2876-8500; Ramirez-delReal, Tania
   Aglae/0000-0002-1638-5086
FU National Council of Humanities, Sciences, and Technologies (CONAHCYT,
   Mxico)
FX The authors gratefully acknowledge Maite Vallejo and Tlalpan 2020
   project advisory group for their logistic support in this work.
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NR 102
TC 2
Z9 2
U1 2
U2 3
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD MAR
PY 2024
VL 16
IS 5
AR 612
DI 10.3390/nu16050612
PG 25
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA KW1Z8
UT WOS:001182921300001
PM 38474741
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Maripuu, M
   Wikgren, M
   Karling, P
   Adolfsson, R
   Norrback, KF
AF Maripuu, Martin
   Wikgren, Mikael
   Karling, Pontus
   Adolfsson, Rolf
   Norrback, Karl-Fredrik
TI Relative hypocortisolism is associated with obesity and the metabolic
   syndrome in recurrent affective disorders
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Affective disorder; Cortisol; Dyslipidemia; Hypocortisolism; Metabolic
   syndrome; Obesity
ID WEEKLY SYMPTOMATIC STATUS; PITUITARY-ADRENAL AXIS; BODY-FAT
   DISTRIBUTION; SALIVARY CORTISOL; CARDIOVASCULAR-DISEASE; DEPRESSIVE
   SYMPTOMS; INSULIN-RESISTANCE; NATURAL-HISTORY; STRESS; DEXAMETHASONE
AB Background: Cardiovascular disease (CVD) is one of the main causes of excess deaths in affective disorders. Affective disorders are associated with increased frequencies of CVD risk-factors such as obesity, dyslipidemia, and metabolic syndrome. Stress-induced chronic cortisol excess has been suggested to promote obesity and metabolic syndrome. Chronic stress with frequent or persisting hypothalamic-pituitary-adrenal-axis (HPA-axis) hyperactivity may, over time, lead to a state of low HPA-axis activity, also denoted hypocortisolism. A low-dose weight-adjusted dexamethasone-suppression-test (DST) is considered to be a sensitive measure of hypocortisolism.
   Methods: 245 patients with recurrent depression or bipolar disorder and 258 controls participated in a low-dose DST and were also examined with regard to metabolic status.
   Results: Patients with hypocortisolism (low post-DST cortisol) compared with patients without hypocortisolism (normal or high post-DST cortisol) exhibited increased odds ratios (OR) for obesity (OR=4.0), overweight (OR=4.0), large waist (OR=2.7), high LDL (OR=4.2), low HDL (OR=2A), high LDL/HDL ratio (OR=3.3), high TC/HDL ratio (OR=3.4) and metabolic syndrome (OR=2.0). A similar pattern but less pronounced was also found in the control sample.
   Limitations: The cross sectional study design and absence of analyses addressing lifestyle factors.
   Conclusions: Our findings suggest that a substantial portion of the metabolic disorders and cardiovascular risk factors seen in recurrent affective disorders are found among individuals exhibiting hypocortisolism. This might indicate that long-term stress is a central contributor to metabolic abnormalities and CVD mortality in recurrent affective disorders. (C) 2016 Elsevier B.V. All rights reserved.
C1 [Maripuu, Martin; Wikgren, Mikael; Adolfsson, Rolf; Norrback, Karl-Fredrik] Umea Univ, Div Psychiat, Dept Clin Sci, SE-90187 Umea, Sweden.
   [Karling, Pontus] Umea Univ, Div Med, Dept Publ Hlth & Clin Med, Umea, Sweden.
C3 Umea University; Umea University
RP Maripuu, M (corresponding author), Umea Univ, Div Psychiat, Dept Clin Sci, SE-90187 Umea, Sweden.
EM martin.maripuu@umu.se
OI Adolfsson, Rolf/0000-0001-9785-8473
FU Swedish Research Council [2006-4472, 2009-5269]; Medical Faculty of Umea
   University; County Council of Jamtland, Sweden; County Council of
   Vasterbotten, Sweden; County Council of Norrbotten, Sweden
FX The research was funded by the Swedish Research Council (Grants
   2006-4472; 2009-5269), the Medical Faculty of Umea University and the
   County Councils of Jamtland, Vasterbotten and Norrbotten, Sweden. The
   funders had no role in study design, data collection and analysis,
   decision to publish, or preparation of the manuscript.
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NR 52
TC 12
Z9 18
U1 0
U2 19
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD NOV 1
PY 2016
VL 204
BP 187
EP 196
DI 10.1016/j.jad.2016.06.024
PG 10
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA DW7FT
UT WOS:000383817300027
PM 27367307
DA 2025-06-11
ER

PT S
AU Matthews, KA
   Gallo, LC
   Taylor, SE
AF Matthews, Karen A.
   Gallo, Linda C.
   Taylor, Shelley E.
BE Adler, NE
   Stewart, J
TI Are psychosocial factors mediators of socioeconomic status and health
   connections? A progress report and blueprint for the future
SO BIOLOGY OF DISADVANTAGE: SOCIOECONOMIC STATUS AND HEALTH
SE Annals of the New York Academy of Sciences
LA English
DT Article; Book Chapter
DE socioeconomic status; emotions; stress; resources; development
ID CORONARY-HEART-DISEASE; EARLY-LIFE STRESS; RISK-FACTORS; METABOLIC
   SYNDROME; SOCIAL SUPPORT; SEROTONERGIC RESPONSIVITY;
   EDUCATIONAL-ATTAINMENT; PSYCHOLOGICAL-FACTORS; FAMILY RELATIONSHIPS;
   BEHAVIORAL-FACTORS
AB The association between socioeconomic status (SES) and physical health is robust. Yet, the psychosocial mediators of SES-health association have been studied in relatively few investigations. In this chapter, we summarize and critique the recent literature regarding negative emotions and cognitions, psychological stress, and resources as potential pathways connecting SES and physical health. We discuss the psychosocial origins of the SES-health links and outline how psychosocial factors may lead to persistently low SES. We conclude that psychosocial resources may play a critical mediating role, and the origins of the SES-health connection are apparent in childhood. We offer a blueprint for future research, which we hope contributes to a better understanding of how SES gets under the skin across the life span.
C1 [Matthews, Karen A.] Univ Pittsburgh, Dept Psychiat, Pittsburgh, PA 15213 USA.
   [Gallo, Linda C.] San Diego State Univ, San Diego, CA 92182 USA.
   [Taylor, Shelley E.] Univ Calif Los Angeles, Los Angeles, CA USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE); University
   of Pittsburgh; California State University System; San Diego State
   University; University of California System; University of California
   Los Angeles
RP Matthews, KA (corresponding author), Univ Pittsburgh, Dept Psychiat, 3811 Ohara St, Pittsburgh, PA 15213 USA.
EM matthewska@upmc.edu
OI Gallo, Linda C./0000-0002-3678-5888
FU NHLBI NIH HHS [R01 HL081604] Funding Source: Medline
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NR 123
TC 278
Z9 348
U1 1
U2 59
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER STREET, HOBOKEN, NJ, UNITED STATES
SN 0077-8923
BN 978-1-57331-770-2
J9 ANN NY ACAD SCI
JI Ann.NY Acad.Sci.
PY 2010
VL 1186
BP 146
EP 173
DI 10.1111/j.1749-6632.2009.05332.x
PG 28
WC Public, Environmental & Occupational Health; Multidisciplinary Sciences
WE Book Citation Index – Science (BKCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health; Science & Technology -
   Other Topics
GA BOX21
UT WOS:000277908000009
PM 20201872
DA 2025-06-11
ER

PT J
AU Gheorghe, AM
   Nistor, C
   Ranetti, AE
   Carsote, M
AF Gheorghe, Ana-Maria
   Nistor, Claudiu
   Ranetti, Aurelian-Emil
   Carsote, Mara
TI An Analysis of Primary Hyperparathyroidism in Association with
   Depression or Anxiety
SO DISEASES
LA English
DT Review
DE primary hyperparathyroidism; depression; anxiety; PTH; calcium;
   parathyroidectomy; parathyroid; hormone; scale; questionnaire; study
ID QUALITY-OF-LIFE; ASYMPTOMATIC PRIMARY HYPERPARATHYROIDISM;
   PARATHYROID-HORMONE; PSYCHOMETRIC PROPERTIES; CEREBROSPINAL-FLUID;
   METABOLIC SYNDROME; HOSPITAL ANXIETY; PRIMARY-CARE; RECEPTOR;
   MANIFESTATIONS
AB Background: Non-classical manifestations such as neuropsychiatric manifestations in primary hyperparathyroidism (PHPT) have long been documented as symptoms of PHPT and are commonly reported by these patients, despite this connection still being a matter of debate, and they (per se) do not represent an indication of parathyroidectomy. Objective: We aimed to overview the most recent findings regarding the link between depression and/or anxiety (D/A) in subjects confirmed with PHPT, including the impact of the surgery in improving their outcome. Methods: This was a comprehensive review of English-based original studies published between January 2020 and October 2024. Results: The studies (n = 16) included a total of 10,325 patients and an additional 152,525 patients with hypercalcemia (out of whom 13,136 had a PHPT diagnosis and 45,081 were at risk of PHPT diagnosis). Out of these subjects with PHPT, 10,068 underwent parathyroidectomy. Female prevalence was between 62.5 and 92%. Most individuals were over 50, with the youngest studied population having a mean age of 52.7 +/- 13.8 years, and the oldest had a median of 71. Depression was documented based on ICD-10 codes (n = 3) and patients' records (n = 2), Depression Anxiety Stress Scales (DASS) (n = 2), Beck Depression Inventory (BDI) (n = 3), BDI-II (n = 3), Symptom Check List 90-revised (SCL) (n = 1), Hamilton Depression Rating Scale (HAM-D) (n = 2), HADS (n = 2), Patient Health Questionnaire-9 (n = 1), and European Quality of Life 5 Dimensions 3-Level Version (EuroQOL-5D-3L) (n = 1). Patient records' (n = 1) and ICD-10 codes (n = 2) were also used for anxiety. Most studies used questionnaires to identify anxiety in PHPT: DASS (n = 2), SCL90R (n = 1), Generalized Anxiety Disorder-7 (n = 1), HADS (n = 2), EuroQOL-5D-3L (n = 1), and State-Trait Anxiety Inventory (n = 1). Depression prevalence varied from 20-36.6% to 65.7% (scale-based assessment) and to 10.5% upon ICD-10. A rate of newly onset depression was reported of 10.7% and of 0.2% with concern to the prevalent suicidal ideation (an incidental rate of 0.4% after a median follow-up of 4.2 years). Most studies identified a moderate depression (when assessing its severity), affecting approximately one third of the surgery candidates. The prevalence of anxiety in PHPT varied between 10.4% and 38.6% (n = 8). Discordant results were generated when applying distinct questionnaires for the same population, and this might come as a potential bias. Other confounding factors are generated by the sub-population referred for surgery that typically displays a more severe parathyroid condition or non-endocrine overlapping conditions (e.g., related to the social or familial status). Conclusion: The modern approach of the patient with PHPT should be complex and go beyond the traditional frame. D/A had a high prevalence in the mentioned studies, associated with increased medication use. Yet, the underlying pathogenic mechanisms remain incompletely elucidated. No correlations between D/A and serum calcium levels were confirmed, while PTH had a slight positive correlation with depression. Parathyroid surgery appears to be beneficial for D/A as it improves the scores, prevalence, and severity. Cinacalcet might reduce depression scores, although more evidence is needed. Women are prone to both PHPT and D/A. The optimal method of D/A screening in PHPT remains to be determined, and the current scales need validation and perhaps adjustment for this specific population sub-group, while PHPT management should be refined upon D/A identification.
C1 [Gheorghe, Ana-Maria] Carol Davila Univ Med & Pharm, PhD Doctoral Sch, Bucharest 020021, Romania.
   [Nistor, Claudiu] Carol Davila Univ Med & Pharm, Dept Cardiothorac Pathol 4, Thorac Surg Discipline 2, Bucharest 050474, Romania.
   [Nistor, Claudiu] Dr Carol Davila Cent Mil Univ Emergency Hosp, Thorac Surg Dept, Bucharest 010242, Romania.
   [Ranetti, Aurelian-Emil; Carsote, Mara] Dr Carol Davila Univ Med & Pharm, Dept Endocrinol, Bucharest 020021, Romania.
   [Ranetti, Aurelian-Emil] Dr Carol Davila Cent Emergency Univ Mil Hosp, Endocrinol Dept, Bucharest 010825, Romania.
   [Carsote, Mara] CI Parhon Natl Inst Endocrinol, Dept Clin Endocrinol 5, Bucharest 011863, Romania.
C3 Carol Davila University of Medicine & Pharmacy; Carol Davila University
   of Medicine & Pharmacy; National Institute of Endocrinology C.I. Parhon
RP Nistor, C (corresponding author), Carol Davila Univ Med & Pharm, Dept Cardiothorac Pathol 4, Thorac Surg Discipline 2, Bucharest 050474, Romania.; Nistor, C (corresponding author), Dr Carol Davila Cent Mil Univ Emergency Hosp, Thorac Surg Dept, Bucharest 010242, Romania.; Ranetti, AE (corresponding author), Dr Carol Davila Univ Med & Pharm, Dept Endocrinol, Bucharest 020021, Romania.; Ranetti, AE (corresponding author), Dr Carol Davila Cent Emergency Univ Mil Hosp, Endocrinol Dept, Bucharest 010825, Romania.
EM ana-maria.gheorghe@drd.umfcd.ro; claudiu.nistor@umfcd.ro;
   aurelian.ranetti@umfcd.ro; carsote_m@hotmail.com
RI Gheorghe, Ana-Maria/HPG-9949-2023; NISTOR, CLAUDIU EDUARD/ABA-3269-2021;
   Ranetti, Aurelian-Emil/JQV-7664-2023
OI Ranetti, Aurelian-Emil/0009-0006-1028-0618
FU Carol Davila University of Medicine and Pharmacy, PhD research "Primary
   hyperparathyroidism: cardio-metabolic, osseous and surgical
   aspects"-2023
FX This research was funded by "Carol Davila" University of Medicine and
   Pharmacy, PhD research "Primary hyperparathyroidism: cardio-metabolic,
   osseous and surgical aspects"-2023.
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NR 130
TC 0
Z9 0
U1 1
U2 1
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2079-9721
J9 DISEASES-BASEL
JI Diseases
PD FEB
PY 2025
VL 13
IS 2
AR 54
DI 10.3390/diseases13020054
PG 34
WC Medicine, Research & Experimental
WE Emerging Sources Citation Index (ESCI)
SC Research & Experimental Medicine
GA Y6J1D
UT WOS:001433151100001
PM 39997061
OA gold
DA 2025-06-11
ER

PT J
AU Franco, CMR
   Lima, AMJ
   Ataíde, L
   Lins, OG
   Castro, CMM
   Bezerra, AA
   de Oliveira, MF
   Oliveira, JRM
AF Franco, C. M. R.
   Lima, A. M. J.
   Ataide, L., Jr.
   Lins, O. G.
   Castro, C. M. M.
   Bezerra, A. A.
   de Oliveira, M. F.
   Oliveira, J. R. M.
TI Obstructive Sleep Apnea Severity Correlates with Cellular and Plasma
   Oxidative Stress Parameters and Affective Symptoms
SO JOURNAL OF MOLECULAR NEUROSCIENCE
LA English
DT Article
DE Obstructive sleep apnea; Oxidative stress; Nitric oxide; Depression;
   Anxiety
ID CIRCULATING NITRIC-OXIDE; DEPRESSIVE SYMPTOMS; LIPID-PEROXIDATION;
   DISORDERS; FATIGUE; QUALITY; EPIDEMIOLOGY; CYTOKINES; ANXIETY;
   PATHOPHYSIOLOGY
AB Obstructive sleep apnea syndrome (OSAS) is considered a sleep-related respiratory disorder, characterized by repetitive episodes of complete (apnea) or partial (hypopnea) obstruction of airflow in the upper airway (UA) during sleep. The pathophysiology of upper airway obstruction in OSAS is multifactorial, leading to a chronic recurrent state of intermittent hypoxemia and reoxygenation during sleep, maintaining a state of oxidative stress, which seems to be the key to the pathophysiological manifestations of OSAS, and is associated with the development of a number of high morbidity-mortality systematic complications, such as obesity, type 2 diabetes, metabolic syndrome, and cardiovascular and neuropsychological diseases. This study is an open, cross-sectional, and comparative clinical trial, whose general objective was to assess the correlation between OSAS severity, oxidative stress markers, and the presence of affective symptoms (depressive and anxious) in OSAS patients. We studied 38 adult males, who had been diagnosed with OSAS by overnight polysomnography, between 18 and 60 years of age, divided into three groups: group 1-10 individuals with mild OSAS (AHI between 5 and 14.9/h), group 2-13 individuals with moderate OSAS (AHI between 15 and 30/h), and group 3-15 individuals with severe OSAS (AHI > 30/h). All individuals were evaluated for level of subjective sleepiness using the Epworth Sleepiness Scale, for depressive and anxiety symptoms by the Hamilton Depression (HAM-D) and Anxiety (HAM-A) Scales, and for parameters of the oxidative stress state, measuring superoxide radical and serum nitrates and nitrites levels. There was a progressive and significant increase in the state of oxidative stress (p < 0.05), in the total score of depressive symptoms (p = 0.001) and in the overall score of anxiety symptoms (p = 0.004) directly proportional to the severity of apnea when comparing the mild group to the severe group. Positive correlations were identified between superoxide production and the apnea-hypopnea index (AHI) (r = 0.48), Epworth sleepiness score (r = 0.36), and Hamilton depression score (HAM-D) (r = 0.40); between serum nitrates and nitrites levels and SO2 min (r = 0.44); and between the AHI and the HAM-D (r = 0.51) score and HAM-A (r = 0.40) score. Negative correlations were observed between the AHI and serum nitrates and nitrites levels (r = -0.42), between superoxide production and SO2 min (r = -0.31), between serum nitrates and nitrites levels and HAM-D (r = -0.50) and HAM-A (-0.42) scores, and between SO2 min and HAM-D (r = -0.48) and HAM-A (r = -0.40) scores. According to the results of this study, we can conclude that (1) individuals with OSAS show an increase in the production of superoxide radical and a decrease in serum nitrates and nitrites levels, which are objective signs of a state of oxidative stress. (2) The more severe the OSAS, the more fragmented the sleep and the greater the nocturnal hypoxemia, the more severe is the oxidative stress state and the greater is the incidence of daytime symptoms, especially sleepiness and depressive and anxiety symptoms. Future studies might explore the investigation of oxidative stress parameters as an alternative approach to anticipate symptoms, measure prognosis, and monitor OSAS progression or treatment response.
C1 [de Oliveira, M. F.] Hosp Servidor Publ Estadual Estado Sao Paulo, Neurosurg Residency Program, Sao Paulo, Brazil.
   [Franco, C. M. R.; Ataide, L., Jr.; Lins, O. G.; Oliveira, J. R. M.] Fed Univ Pernambuco UFPE, Neuropsychiat Dept, Recife, PE, Brazil.
   [Franco, C. M. R.; Lins, O. G.] Fed Univ Pernambuco UFPE, Clin Neurophysiol Lab, Recife, PE, Brazil.
   [Lima, A. M. J.] Rural Fed Univ Pernambuco, Dept Physiol, Recife, PE, Brazil.
   [Castro, C. M. M.; Bezerra, A. A.; Oliveira, J. R. M.] Fed Univ Pernambuco UFPE, Keizo Asami Immunopathol Lab LIKA, Recife, PE, Brazil.
C3 Instituto de Assistencia Medica ao Servidor Publico Estadual (IAMSPE);
   Universidade Federal de Pernambuco; Universidade Federal de Pernambuco;
   Universidade Federal Rural de Pernambuco (UFRPE); Universidade Federal
   de Pernambuco
RP de Oliveira, MF (corresponding author), Hosp Servidor Publ Estadual Estado Sao Paulo, Neurosurg Residency Program, Av Pedro de Toledo,1800 Vila Clementino, Sao Paulo, Brazil.
EM mafernoliv@yahoo.com.br
RI Lima, Anna/AGN-8610-2022; de Oliveira, João/GWV-0126-2022
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NR 63
TC 39
Z9 40
U1 0
U2 10
PU HUMANA PRESS INC
PI TOTOWA
PA 999 RIVERVIEW DRIVE SUITE 208, TOTOWA, NJ 07512 USA
SN 0895-8696
EI 1559-1166
J9 J MOL NEUROSCI
JI J. Mol. Neurosci.
PD JUN
PY 2012
VL 47
IS 2
BP 300
EP 310
DI 10.1007/s12031-012-9738-0
PG 11
WC Biochemistry & Molecular Biology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Biochemistry & Molecular Biology; Neurosciences & Neurology
GA 949HQ
UT WOS:000304567700010
PM 22402994
DA 2025-06-11
ER

PT J
AU Kendall-Tackett, KA
AF Kendall-Tackett, Kathleen A.
TI Inflammation, cardiovascular disease, and metabolic syndrome as sequelae
   of violence against women - The role of depression, hostility, and sleep
   disturbance
SO TRAUMA VIOLENCE & ABUSE
LA English
DT Article
DE abuse; inflammation; depression; hostility; sleep disorders
ID POSTTRAUMATIC-STRESS-DISORDER; CORONARY HEART-DISEASE; SEAFOOD
   CONSUMPTION; HEALTH-STATUS; SYMPTOMS; CYTOKINES; QUALITY; EXPRESSION;
   SEVERITY; THERAPY
AB Women who experience violence are significantly more likely to have serious health problems above and beyond any injuries they might incur. The intriguing question is why this is so. In this article, the author describes how three sequelae of violence against women-depression, hostility, and sleep disturbance-can increase the risk of disease. One possible mechanism by which these sequelae increase risk is by elevating levels of pro-inflammatory cytokines. These cytokines have an adaptive function infighting infection and repairing injured tissues. However, chronically high levels of pro-inflammatory cytokines have been implicated in a wide range of diseases. The author focuses on two illnesses that have not received much attention in the violence against women (VAW) literature: cardiovascular disease and metabolic syndrome, the precursor to type 2 diabetes. Preliminary studies also suggest that treatments that can lower inflammation may be promising adjuncts for survivors of VAW.
C1 Univ New Hampshire, Family Res Lab, Durham, NH 03824 USA.
C3 University System Of New Hampshire; University of New Hampshire
RP Kendall-Tackett, KA (corresponding author), Univ New Hampshire, Family Res Lab, Durham, NH 03824 USA.
OI Kendall-Tackett, Kathleen/0000-0003-0709-1059
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NR 52
TC 40
Z9 78
U1 0
U2 6
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1524-8380
EI 1552-8324
J9 TRAUMA VIOLENCE ABUS
JI Trauma Violence Abus.
PD APR
PY 2007
VL 8
IS 2
SI SI
BP 117
EP 126
DI 10.1177/1524838007301161
PG 10
WC Criminology & Penology; Family Studies; Social Work
WE Social Science Citation Index (SSCI)
SC Criminology & Penology; Family Studies; Social Work
GA 167FC
UT WOS:000246435700004
PM 17545569
DA 2025-06-11
ER

PT J
AU Wong, SK
   Chin, KY
   Ima-Nirwana, S
AF Wong, Sok Kuan
   Chin, Kok-Yong
   Ima-Nirwana, Soelaiman
TI Vitamin C: A Review on its Role in the Management of Metabolic Syndrome
SO INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
LA English
DT Review
DE antioxidants; ascorbic acid; ascorbate; inflammation; oxidative stress
ID SERUM ANTIOXIDANT CONCENTRATIONS; OXIDATIVE STRESS;
   PLASMA-CONCENTRATIONS; SYNDROME PARAMETERS; NATIONAL-HEALTH; SYNDROME-X;
   SUPPLEMENTATION; INFLAMMATION; ADULTS; RISK
AB Oxidative stress and inflammation are two interlinked events that exist simultaneously in metabolic syndrome (MetS) and its related complications. These pathophysiological processes can be easily triggered by each other. This review summarizes the current evidence from animal and human studies on the effects of vitamin C in managing MetS. In vivo studies showed promising effects of vitamin C, but most of the interventions used were in combination with other compounds. The direct effects of vitamin C remain to be elucidated. In humans, the current state of evidence revealed that lower vitamin C intake and circulating concentration were found in MetS subjects. A negative relationship was observed between vitamin C intake / concentration and the risk of MetS. Oral supplementation of vitamin C also improved MetS conditions. It has been postulated that the positive outcomes of vitamin C may be in part mediated through its anti-oxidative and anti-inflammatory properties. These observations suggest the importance of MetS patients to have an adequate intake of vitamin C through food, beverages or supplements in order to maintain its concentration in the systemic circulation and potentially reverse MetS.
C1 [Wong, Sok Kuan; Chin, Kok-Yong; Ima-Nirwana, Soelaiman] Univ Kebangsaan Malaysia, Fac Med, Dept Pharmacol, Jalan Yaacob Latif, Kuala Lumpur 56000, Malaysia.
C3 Universiti Kebangsaan Malaysia
RP Ima-Nirwana, S (corresponding author), Univ Kebangsaan Malaysia, Fac Med, Dept Pharmacol, Jalan Yaacob Latif, Kuala Lumpur 56000, Malaysia.
EM imasoel@ppukm.ukm.edu.my
RI Soelaiman, Ima/C-4289-2017; Wong, Sok Kuan/I-1243-2016; Chin,
   Kok-Yong/B-6309-2015
OI Wong, Sok Kuan/0000-0003-1184-4551; Chin, Kok-Yong/0000-0001-6628-1552
FU Universiti Kebangsaan Malaysia; Ministry of Education, Malaysia
   [MI-2019-006, FRGS/1/2018/SKK10/UKM/03/1]
FX This work was supported by Universiti Kebangsaan Malaysia and Ministry
   of Education, Malaysia for supporting this work via MI-2019-006 and
   FRGS/1/2018/SKK10/UKM/03/1 grants.
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NR 85
TC 51
Z9 53
U1 2
U2 7
PU IVYSPRING INT PUBL
PI LAKE HAVEN
PA PO BOX 4546, LAKE HAVEN, NSW 2263, AUSTRALIA
SN 1449-1907
J9 INT J MED SCI
JI Int. J. Med. Sci.
PY 2020
VL 17
IS 11
BP 1625
EP 1638
DI 10.7150/ijms.47103
PG 14
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA NH4XX
UT WOS:000564675800006
PM 32669965
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Atasoy, S
   Johar, H
   Herder, C
   Rathmann, W
   Koenig, W
   Roden, M
   Peters, A
   Kruse, J
   Ladwig, KH
AF Atasoy, Seryan
   Johar, Hamimatunnisa
   Herder, Christian
   Rathmann, Wolfgang
   Koenig, Wolfgang
   Roden, Michael
   Peters, Annette
   Kruse, Johannes
   Ladwig, Karl-Heinz
TI Generalized anxiety disorder symptoms and type 2 diabetes onset:
   Findings from the Prospective Cooperative Health Research in the Region
   of Augsburg F4 and FF4 studies
SO JOURNAL OF PSYCHOSOMATIC RESEARCH
LA English
DT Article
DE Anxiety; Type 2 diabetes incidence
ID HEART-RATE-VARIABILITY; INSULIN-RESISTANCE; SCREENER GAD-7; STRESS;
   RISK; MELLITUS
AB Objective: To investigate the association of generalized anxiety disorder (GAD) symptomology on the incidence of type 2 diabetes.
   Research design & methods: Participants from the prospective KORA F4/FF4 German cohort were followed for a mean of 6.5 years. Generalized Anxiety Disorder Scale-7 (GAD-7) was used to assess GAD symptoms and incident type 2 diabetes cases were confirmed using a standard oral glucose tolerance test. Multivariate logistic regression models were used to estimate the effect of GAD symptoms on the incidence of type 2 diabetes.
   Results: The present study included 1694 participants (51.8% women, 48.2% men) with a mean age of 51.2 years, among whom 113 (6.7%) had high GAD symptoms. During the follow-up period (11,102 person/years), 113 (6.5%) type 2 diabetes cases were confirmed. Participants with GAD symptoms had 2-fold higher incidence of type 2 diabetes than participants without GAD (17.7 vs. 8.7 cases/1000 person-years). Correspondingly, GAD symptoms independently increased the risk of type 2 diabetes by an odds ratio of 2.09 [95%CI 1.02-4.32, p = 0.04] after adjustment for concurrent sociodemographic, lifestyle and cardiometabolic risk factors, high sensitivity C-reactive protein, depression, and the use of antidepressant medications. Additionally, GAD symptoms had an even larger impact on the onset of type 2 diabetes incidence following additional adjustment for prediabetes at baseline (2.68 [1.23-5.88], p=0.01).
   Conclusions: Participants with GAD symptoms had 2-times higher odds of type 2 diabetes incidence during 6.5 years of follow-up, highlighting the significant role of dysregulated stress mechanisms in the pathway to developing type 2 diabetes.
C1 [Atasoy, Seryan; Johar, Hamimatunnisa; Kruse, Johannes] Univ Giessen & Marburg, Dept Psychosomat Med & Psychotherapy, Giessen, Germany.
   [Atasoy, Seryan; Ladwig, Karl-Heinz] Tech Univ Munich, Dept Psychosomat Med & Psychotherapy, Klinikum Rechts Isar, Munich, Germany.
   [Atasoy, Seryan; Johar, Hamimatunnisa; Peters, Annette; Ladwig, Karl-Heinz] Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Epidemiol, Neuherberg, Germany.
   [Herder, Christian; Rathmann, Wolfgang; Roden, Michael] German Ctr Diabet Res DZD, Dusseldorf, Germany.
   [Atasoy, Seryan; Johar, Hamimatunnisa; Peters, Annette; Kruse, Johannes; Ladwig, Karl-Heinz] Helmholtz Zentrum Munchen, German Ctr Diabet Res DZD, Munich, Germany.
   [Herder, Christian; Rathmann, Wolfgang; Roden, Michael] Heinrich Heine Univ Dusseldorf, Leibniz Ctr Diabet Res, German Diabet Ctr, Inst Clin Diabetol, Dusseldorf, Germany.
   [Herder, Christian; Roden, Michael] Heinrich Heine Univ Dusseldorf, Fac Med, Div Endocrinol & Diabetol, Dusseldorf, Germany.
   [Rathmann, Wolfgang] Heinrich Heine Univ Dusseldorf, Leibniz Ctr Diabet Res, German Diabet Ctr, Inst Biometr & Epidemiol, Dusseldorf, Germany.
   [Koenig, Wolfgang] Tech Univ Munich, Deutsch Herzzentrum Munchen, Munich, Germany.
   [Koenig, Wolfgang] Partner Site Munich Heart Alliance, German Ctr Cardiovasc Res, Munich, Germany.
   [Koenig, Wolfgang] Univ Ulm, Inst Epidemiol & Med Biometry, Ulm, Germany.
C3 Technical University of Munich; Helmholtz Association; Helmholtz-Center
   Munich - German Research Center for Environmental Health; German Center
   for Diabetes Research (DZD); Helmholtz Association; Helmholtz-Center
   Munich - German Research Center for Environmental Health; German Center
   for Diabetes Research (DZD); Leibniz Association; Deutsches
   Diabetes-Zentrum (DDZ); Heinrich Heine University Dusseldorf; Heinrich
   Heine University Dusseldorf; Leibniz Association; Deutsches
   Diabetes-Zentrum (DDZ); Heinrich Heine University Dusseldorf; German
   Heart Centre Munich; Technical University of Munich; German Centre for
   Cardiovascular Research; Munich Heart Alliance; Ulm University
RP Ladwig, KH (corresponding author), Tech Univ Munchen TUM, Dept Psychosomat Med & Psychotherapy, Klinikum Rechts Isar, Langerstr 3, D-81675 Munich, Germany.
EM karl-heinz.ladwig@tum.de
RI Johar, Hamimatunnisa/AAV-4437-2020; Qasrawi, Radwan/AAA-6245-2019;
   Ladwig, Karl-Heinz/B-5351-2014; Roden, Michael/AAD-3843-2019; Koenig,
   Wolfgang/JCF-0788-2023; Peters, Annette/A-6117-2011
OI Koenig, Wolfgang/0000-0002-2064-9603; Peters,
   Annette/0000-0001-6645-0985; Johar, Hamimatunnisa/0000-0001-8713-4121
FU Helmholtz Zentrum Munchen; German Research Center for Environmental
   Health - German Federal Ministry of Education and Research (BMBF); State
   of Bavaria; German Center for Diabetes Research (Deutsches Zentrum fur
   Diabetesforschung)
FX The KORA research platform and the KORA Augsburg studies are financed by
   the Helmholtz Zentrum Munchen, German Research Center for Environmental
   Health, which is funded by the German Federal Ministry of Education and
   Research (BMBF) and by the State of Bavaria. This work was supported by
   a grant from the German Center for Diabetes Research (Deutsches Zentrum
   fur Diabetesforschung).
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NR 44
TC 11
Z9 12
U1 0
U2 3
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-3999
EI 1879-1360
J9 J PSYCHOSOM RES
JI J. Psychosomat. Res.
PD JUN
PY 2021
VL 145
AR 110480
DI 10.1016/j.jpsychores.2021.110480
EA MAY 2021
PG 5
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA SA1HZ
UT WOS:000649050200042
PM 33865610
DA 2025-06-11
ER

PT S
AU Pervanidou, P
   Chrousos, GP
AF Pervanidou, Panagiota
   Chrousos, George P.
BE Martini, L
   Chrousos, GP
   Labrie, F
   Pacak, K
   Pfaff, DW
TI Neuroendocrinology of post-traumatic stress disorder
SO NEUROENDOCRINOLOGY: PATHOLOGICAL SITUATIONS AND DISEASES
SE Progress in Brain Research
LA English
DT Review; Book Chapter
DE hypothalamic-pituitary-adrenal (HPA) axis; locus caeruleus;
   norepinephrine; sympathetic nervous system; psychiatric disorders;
   co-morbid disorders
ID URINARY CATECHOLAMINE EXCRETION; SALIVARY CORTISOL; PLASMA
   NOREPINEPHRINE; PTSD SYMPTOMS; BENZODIAZEPINE-RECEPTOR; HOLOCAUST
   SURVIVORS; VIETNAM VETERANS; COMBAT; NEUROBIOLOGY; TRAUMA
AB Dysregulation of the stress system, including the hypothalamic-pituitary-adrenal (HPA) axis and the locus caeruleus/norepinephrine-sympathetic nervous system (SNS), is involved in the pathophysiology of post-traumatic stress disorder (PTSD), an anxiety disorder that develops after exposure to traumatic life events. Neuroendocrine studies in individuals with PTSD have demonstrated elevated basal cerebrospinal fluid corticotropin-releasing hormone concentrations and contradictory results from peripheral measurements, exhibiting low 24 hours excretion of urinary free cortisol, low or normal circulating cortisol levels or even high plasma cortisol levels. The direction of HPA axis activity (hyper-/or hypo-activation), as evidenced by peripheral cortisol measures, may depend on variables such as genetic vulnerability and epigenetic changes, age and developmental stage of the individual, type and chronicity of trauma, co-morbid depression or other psychopathology, alcohol or other drug abuse and time since the traumatic experience. On the other hand, peripheral biomarkers of the SNS activity are more consistent, showing increased 24 h urinary or plasma catecholamines in PTSD patients compared to control individuals. Chronically disturbed hormones in PTSD may contribute to brain changes and further emotional and behavior symptoms and disorders, as well as to an increased cardiometabolic risk.
C1 [Pervanidou, Panagiota] Univ Athens, Sch Med, Agia Sophia Childrens Hosp, Dev & Behav Pediat Unit,Dept Pediatr 1, GR-11527 Athens, Greece.
   [Chrousos, George P.] Univ Athens, Agia Sophia Childrens Hosp, Div Endocrinol Diabet & Metab, Dept Pediat 1, Athens, Greece.
C3 Athens Medical School; The Aghia Sophia Children's Hospital; National &
   Kapodistrian University of Athens; The Aghia Sophia Children's Hospital;
   National & Kapodistrian University of Athens
RP Pervanidou, P (corresponding author), Univ Athens, Sch Med, Agia Sophia Childrens Hosp, Dev & Behav Pediat Unit,Dept Pediatr 1, GR-11527 Athens, Greece.
EM ppervanid@med.uoa.gr
RI Pervanidou, Panagiota/ABI-6356-2020; Chrousos, George/G-8702-2011
OI Pervanidou, Panagiota/0000-0002-6593-6489
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NR 69
TC 105
Z9 121
U1 4
U2 56
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA SARA BURGERHARTSTRAAT 25, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0079-6123
BN 978-0-444-53616-7
J9 PROG BRAIN RES
JI Prog. Brain Res.
PY 2010
VL 182
BP 149
EP 160
DI 10.1016/S0079-6123(10)82005-9
PG 12
WC Endocrinology & Metabolism; Neurosciences
WE Book Citation Index – Science (BKCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology
GA BTR40
UT WOS:000287858500005
PM 20541663
DA 2025-06-11
ER

PT J
AU Soria, CA
   Remedi, C
   Núñez, DA
   D'Alessio, L
   Roldán, EJA
AF Soria, Carlos A.
   Remedi, Carolina
   Nunez, Daniel A.
   D'Alessio, Luciana
   Roldan, Emilio J. A.
TI Impact of alprazolam in allostatic load and neurocognition of patients
   with anxiety disorders and chronic stress (GEMA): observational study
   protocol
SO BMJ OPEN
LA English
DT Article
ID TERM BENZODIAZEPINE USE; SALIVARY CORTISOL; PANIC DISORDER;
   ALPHA-AMYLASE; DEPRESSION; RESPONSES; 3-METHOXY-4-HYDROXYPHENYLGLYCOL;
   LIFE; RISK; NEUROENDOCRINE
AB Introduction: The allostatic load model explains the additive effects of multiple biological processes that accelerate pathophysiology related to stress, particularly in the central nervous system. Stress-related mental conditions such as anxiety disorders and neuroticism (a well-known stress vulnerability factor), have been linked to disturbances of hypothalamo-pituitary-adrenal with cognitive implications. Nevertheless, there are controversial results in the literature and there is a need to determine the impact of the psychopharmacological treatment on allostatic load parameters and in cognitive functions. Gador study of Estres Modulation by Alprazolam, aims to determine the impact of medication on neurobiochemical variables related to chronic stress, metabolic syndrome, neurocognition and quality of life in patients with anxiety, allostatic load and neuroticism.
   Methods/analysis: In this observational prospective phase IV study, highly sympthomatic patients with anxiety disorders (six or more points in the Hamilton-A scale), neuroticism (more than 18 points in the Neo five personality factor inventory (NEO-FFI) scale), an allostatic load (three positive clinical or biochemical items at Crimmins and Seeman criteria) will be included. Clinical variables of anxiety, neuroticism, allostatic load, neurobiochemical studies, neurocognition and quality of life will be determined prior and periodically (1, 2, 4, 8, and 12 weeks) after treatment (on demand of alprazolam from 0.75 mg/day to 3.0 mg/day). A sample of n=55/182 patients will be considered enough to detect variables higher than 25% (pretreatment vs post-treatment or significant correlations) with a 1-beta power of 0-80. t Test and/or non-parametric test, and Pearson's test for correlation analysis will be determined.
   Ethics and dissemination: This study protocol was approved by an Independent Ethics Committee of FEFyM (Foundation for Pharmacological Studies and Drugs, Buenos Aires) and by regulatory authorities of Argentina (ANMAT, Dossier # 61 409-8 of 20 April 2009), following the law of Habeas Data and psychotherapeutic drug control.
C1 [Soria, Carlos A.; Remedi, Carolina; D'Alessio, Luciana] Inst Biosci Henri Laborit, Dept Cordoba, Buenos Aires, DF, Argentina.
   [Nunez, Daniel A.; Roldan, Emilio J. A.] Gador SA, Dept Sci Direct, Buenos Aires, DF, Argentina.
RP D'Alessio, L (corresponding author), Inst Biosci Henri Laborit, Dept Cordoba, Buenos Aires, DF, Argentina.
EM luladalessio@gmail.com
OI D'Alessio, Luciana/0000-0002-2431-5547; roldan,
   emilio/0000-0002-8472-617X
FU Gador SA, Buenos Aires; Instituto de Biociencias Henri Laborit, Cordoba
FX This work is carried out under a grant awarded by Gador SA, Buenos Aires
   (2010-2012) and funds of the Instituto de Biociencias Henri Laborit,
   Cordoba.
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NR 84
TC 6
Z9 6
U1 0
U2 7
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2044-6055
J9 BMJ OPEN
JI BMJ Open
PY 2015
VL 5
IS 7
AR e007231
DI 10.1136/bmjopen-2014-007231
PG 9
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA CU4FH
UT WOS:000363482000015
PM 26173716
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Nieto-Martínez, R
   González-Rivas, JP
   Ugel, E
   Duran, M
   Dávila, E
   Constantino, R
   García, A
   Mechanick, J
   Marulanda, MI
AF Nieto-Martinez, Ramfis
   Gonzalez-Rivas, Juan P.
   Ugel, Eunice
   Duran, Maritza
   Davila, Eric
   Constantino, Ramez
   Garcia, Alberto
   Mechanick, Jeffrey, I
   Ines Marulanda, Maria
TI Cardiometabolic risk factors in Venezuela. The EVESCAM study: a national
   cross-sectional survey in adults
SO PRIMARY CARE DIABETES
LA English
DT Article
DE Venezuela; Risk factors; Cardiovascular disease; Tobacco; Dyslipidemia;
   Diabetes; Obesity
ID CARDIOVASCULAR-DISEASE; POOLED ANALYSIS; LATIN-AMERICA; 3 REGIONS;
   POPULATION; PREVALENCE; COUNTRIES; HYPERTENSION; GUIDELINES; MANAGEMENT
AB Background: No previous study in Venezuela and few in the Region of the Americas have reported national cardiometabolic health data. Objectives: To determine the prevalence and distribution of cardiometabolic risk factors (CMRF) in adults of Venezuela.
   Methods: A population-based, cross-sectional, and randomized cluster sampling national study was designed to recruit 4454 adults with 20 years or older from the eight regions of the country from July 2014 to January 2017. Sociodemographic, clinical, physical activity, nutritional, and psychological questionnaires; anthropometrics, blood pressure, and biochemical measurements were obtained. The results were weighted by gender, age, and regions.
   Results: Data from 3414 participants (77% of recruited), 52.2% female, mean age of 41.2 +/- 15.8 years, were analyzed. CMRF adjusted-prevalence were: diabetes (12.3%), prediabetes (34.9%), hypertension (34.1%), obesity (24.6%), overweight (34.4%), abdominal obesity (47.6%), underweight (4.4%), hypercholesterolemia (19.8%), hypertriglyceridemia (22.7%), low HDL-cholesterol (63.2%), high LDL-c (20.5%), daily consumption of fruits (20.9%) and vegetables (30.0%), insufficient physical activity (35.2%), anxiety (14.6%) and depression (3.2%) symptoms, current smoker (11.7%), and high (>= 20%) 10-year fatal cardiovascular risk (14.0%). CMRF prevalence varied according to gender, age and region of residence.
   Conclusions: Cardiometabolic risk factors are highly prevalent in Venezuelan adults. This situation can be affected by the severe socio-economic crisis in the country. The joint action of different stakeholders to implement public health strategies for the prevention and treatment of these risk factors in Venezuela is urgently needed. (C) 2020 Primary Care Diabetes Europe. Published by Elsevier Ltd. All rights reserved.
C1 [Nieto-Martinez, Ramfis] LifeDoc Hlth, Memphis, TN USA.
   [Nieto-Martinez, Ramfis; Gonzalez-Rivas, Juan P.] Harvard Univ, Harvard TH Chan Sch Publ Hlth, Dept Global Hlth & Populat, Boston, MA 02115 USA.
   [Nieto-Martinez, Ramfis] Univ Ctr Occident Lisandro Alvarado, Sch Med, Dept Physiol, Barquisimeto, Venezuela.
   [Nieto-Martinez, Ramfis] Cardiometab Unit 7, Barquisimeto, Venezuela.
   [Nieto-Martinez, Ramfis; Gonzalez-Rivas, Juan P.; Ugel, Eunice; Duran, Maritza; Ines Marulanda, Maria] Fdn Clin Publ Hlth & Epidemiol Res Venezuela FISP, Caracas, Venezuela.
   [Gonzalez-Rivas, Juan P.] St Annes Univ Hosp FNUSA Brno, Int Clin Res Ctr ICRC, Brno, Czech Republic.
   [Ugel, Eunice] Univ Ctr Occident Lisandro Alvarado, Sch Med, Dept Social & Prevent Med, Publ Hlth Res Unit, Barquisimeto, Venezuela.
   [Davila, Eric] Univ Cent Venezuela UCV, Sch Med Dr Luis Razetti, Dept Internal Med, Caracas, Venezuela.
   [Constantino, Ramez] Univ Carabobo, Sch Med, Dept Internal Med, Valencia, Venezuela.
   [Garcia, Alberto] Univ Cent Venezuela UCV, Dept Physiol, Sch Med Dr Luis Razetti, Caracas, Venezuela.
   [Mechanick, Jeffrey, I] Icahn Sch Med Mt Sinai, Marie Josee & Henry R Kravis Ctr Cardiovasc Hlth, Mt Sinai Heart, New York, NY 10029 USA.
   [Mechanick, Jeffrey, I] Icahn Sch Med Mt Sinai, Div Endocrinol Diabet & Bone Dis, New York, NY 10029 USA.
C3 Harvard University; Harvard T.H. Chan School of Public Health; St.
   Anne's University Hospital Brno (FNUSA); University of Central
   Venezuela; University of Central Venezuela; Icahn School of Medicine at
   Mount Sinai; Icahn School of Medicine at Mount Sinai
RP González-Rivas, JP (corresponding author), St Annes Univ, Int Clin Res Ctr, Hosp Brno Pekarska 53, Brno 65691, Czech Republic.
EM nietoramfis@hsph.harvard.edu; juan.gonzalez@fnusa.cz
RI Gonzalez Rivas, Juan Pablo/HZK-6756-2023; Martinez, Andrea/KHX-0081-2024
OI Nieto-Martinez, Ramfis/0000-0002-0575-7534; Garcia Gonzalez, Alberto
   Jose/0000-0003-3167-2603
FU Novartis
FX The EVESCAM was partially funded by a grant of Novartisand donations.
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NR 41
TC 7
Z9 8
U1 0
U2 4
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 1751-9918
EI 1878-0210
J9 PRIM CARE DIABETES
JI Prim. Care Diabetes
PD FEB
PY 2021
VL 15
IS 1
BP 106
EP 114
DI 10.1016/j.pcd.2020.07.006
PG 9
WC Endocrinology & Metabolism; Primary Health Care
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; General & Internal Medicine
GA PN6WI
UT WOS:000604616900019
PM 32768283
DA 2025-06-11
ER

PT J
AU Wang, HJ
   Mueller, NT
   Li, JP
   Sun, NL
   Huo, Y
   Ren, FZ
   Wang, XB
AF Wang, Hongjian
   Mueller, Noel T.
   Li, Jianping
   Sun, Ninglin
   Huo, Yong
   Ren, Fazheng
   Wang, Xiaobin
TI Association of Maternal Plasma Folate and Cardiometabolic Risk Factors
   in Pregnancy with Elevated Blood Pressure of Offspring in Childhood
SO AMERICAN JOURNAL OF HYPERTENSION
LA English
DT Article
DE blood pressure; child; hypertension; interaction; maternal
   cardiometabolic risk factors; maternal folate
ID FOLIC-ACID; CARDIOVASCULAR-DISEASE; INSULIN-RESISTANCE; OXIDATIVE
   STRESS; FOLLOW-UP; HYPERTENSION; BIRTH; SUPPLEMENTATION; NUTRITION;
   OBESITY
AB BACKGROUND
   The prevalence of childhood elevated blood pressure (BP) has increased in the United States, particularly among African Americans. The influence of maternal plasma folate levels, alone or in combination with maternal cardiometabolic risk factors (hypertensive disorders, diabetes, and prepregnancy obesity), on child systolic BP (SBP) has not been examined in a prospective birth cohort. We hypothesize that adequate maternal folate levels can reduce the risk of elevated SBP in children born to mothers with cardiometabolic risk factors.
   METHODS
   This study included 1,290 mother-child dyads (875 African Americans (67.8%)) recruited at birth and followed prospectively up to age 9 years from 2003 to 2014 at the Boston Medical Center. Child SBP percentile was calculated according to US reference data and elevated SBP was defined as SBP >= 75th percentile.
   RESULTS
   Maternal folate levels, overall, were not associated with child SBP. However, we found a significant multiplicative interaction between maternal cardiometabolic risk factors and maternal folate levels (P-interaction = 0.015) on childhood elevated SBP. Among children born to mothers with any cardiometabolic risk factors, those whose mothers had folate levels above (vs. below) the median had 40% lower odds of elevated childhood SBP (odds ratio = 0.60, 95% confidence interval: 0.40-0.90). The associations did not differ appreciably in analyses restricted to African Americans, and they were not explained by gestational age, size at birth, prenatal folate intake, or breastfeeding.
   CONCLUSIONS
   Findings from our urban minority birth cohort suggest that higher levels of maternal folate may help counteract the adverse associations of maternal cardiometabolic risk factors on child SBP.
C1 [Wang, Hongjian] Chinese Acad Med Sci, Natl Ctr Cardiovasc Dis, Fuwai Hosp,Natl Clin Res Ctr Cardiovasc Dis, State Key Lab Cardiovasc Dis,Dept Cardiovasc Inte, Beijing, Peoples R China.
   [Wang, Hongjian] Peking Union Med Coll, Beijing, Peoples R China.
   [Wang, Hongjian; Wang, Xiaobin] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Populat Family & Reprod Hlth, Ctr Early Life Origins Dis, Baltimore, MD 21218 USA.
   [Mueller, Noel T.] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA.
   [Mueller, Noel T.] Johns Hopkins Univ, Welch Ctr Prevent Epidemiol & Clin Res, Baltimore, MD USA.
   [Li, Jianping; Huo, Yong] Peking Univ, Dept Cardiol, Hosp 1, Beijing, Peoples R China.
   [Sun, Ninglin] Peking Univ, Dept Cardiol, Peoples Hosp, Beijing, Peoples R China.
   [Ren, Fazheng] China Agr Univ, Coll Food Sci & Nutr Engn, Beijing Lab Food Qual & Safety, Beijing Adv Innovat Ctr Food Nutr & Human Hlth, Beijing, Peoples R China.
   [Ren, Fazheng] China Agr Univ, Coll Food Sci & Nutr Engn, Key Lab Funct Dairy, Beijing, Peoples R China.
   [Wang, Xiaobin] Johns Hopkins Univ, Sch Med, Dept Pediat, Div Gen Pediat & Adolescent Med, Baltimore, MD 21205 USA.
C3 Chinese Academy of Medical Sciences - Peking Union Medical College; Fu
   Wai Hospital - CAMS; Chinese Academy of Medical Sciences - Peking Union
   Medical College; Peking Union Medical College; Johns Hopkins University;
   Johns Hopkins Bloomberg School of Public Health; Johns Hopkins
   University; Johns Hopkins Bloomberg School of Public Health; Johns
   Hopkins University; Peking University; Peking University; China
   Agricultural University; China Agricultural University; Johns Hopkins
   University
RP Wang, XB (corresponding author), Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Populat Family & Reprod Hlth, Ctr Early Life Origins Dis, Baltimore, MD 21218 USA.; Wang, XB (corresponding author), Johns Hopkins Univ, Sch Med, Dept Pediat, Div Gen Pediat & Adolescent Med, Baltimore, MD 21205 USA.
EM xwang82@jhu.edu
OI Mueller, Noel/0000-0002-7412-8352
FU March of Dimes PERI grant [20-FY02-56, 21-FY07-605]; National Institutes
   of Health (NIH) [R21ES011666, 2R01HD041702, R21HD066471]; NIH
   [U01AI090727, R21AI079872, R01HD086013]; Maternal and Child Health
   Bureau [R40MC27443]; Chinese Scholarships Council scholarship; National
   Natural Science Foundation of China [81300156]; PUMC Youth Fund/the
   Fundamental Research Funds for the Central Universities [3332015103]
FX The Boston Birth Cohort (the parent study) was supported in part by the
   March of Dimes PERI grants (20-FY02-56, #21-FY07-605), and the National
   Institutes of Health (NIH) grants (R21ES011666, 2R01HD041702,
   R21HD066471). The follow-up study is supported in part by the NIH grants
   (U01AI090727, R21AI079872, R01HD086013); and the Maternal and Child
   Health Bureau (R40MC27443). Dr Hongjian Wang is supported by a Chinese
   Scholarships Council scholarship, grants from the National Natural
   Science Foundation of China (81300156) and the PUMC Youth Fund/the
   Fundamental Research Funds for the Central Universities (3332015103).
   The sponsors had no role in the design and/or conduct of the study; in
   the collection, analysis, or interpretation of the data; or in the
   preparation, review, or approval of the manuscript.
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NR 36
TC 15
Z9 18
U1 0
U2 13
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0895-7061
EI 1941-7225
J9 AM J HYPERTENS
JI Am. J. Hypertens.
PD MAY
PY 2017
VL 30
IS 5
BP 532
EP 540
DI 10.1093/ajh/hpx003
PG 9
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA EY5NN
UT WOS:000404024000016
PM 28338750
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Karge, RA
   Curtain, CM
   Salahudeen, MS
AF Karge, Rahnee A.
   Curtain, Colin M.
   Salahudeen, Mohammed S.
TI Community Pharmacists' Role in Reducing the Incidence of Cardiometabolic
   Adverse Drug Events in Schizophrenia: Insights from Mental Health
   Professionals
SO MEDICINA-LITHUANIA
LA English
DT Article
DE schizophrenia; community pharmacists; cardiometabolic; mental health;
   qualitative study
ID METABOLIC SYNDROME; CARDIOVASCULAR-DISEASE; ANTIPSYCHOTICS; MANAGEMENT;
   IMPACT; CARE; INTERVENTIONS; SERVICES; OUTCOMES
AB Background and Objectives: Schizophrenia, a debilitating mental illness, is often associated with significant physical health risks. Many second-generation antipsychotics increase the risk of metabolic syndrome and cardiovascular disease. Community pharmacists are highly accessible and could play a role in monitoring cardiometabolic adverse drug events in people with schizophrenia. However, it remains uncertain whether mental health professionals perceive this as valuable. This study aimed to explore the opinions of mental healthcare professionals regarding the role of community pharmacists in reducing the incidence of cardiometabolic adverse events in people with schizophrenia and their integration into a multidisciplinary mental health team. Materials and Methods: Qualitative semi-structured interviews were conducted with Australian psychiatrists, mental health nurses and mental health pharmacists. Transcription of the interviews underwent thematic analysis using an inductive approach. Results: Eleven mental healthcare professionals from metropolitan and regional areas across Australia were interviewed, leading to the identification of five overarching themes. These themes encompassed the following aspects: the benefits of community pharmacists' involvement in managing cardiometabolic adverse drug events in people with schizophrenia, improving communication pathways with community pharmacists, defining roles and responsibilities for monitoring cardiometabolic parameters and managing adverse cardiometabolic drug events, fostering collaboration between community pharmacists and mental health care professionals, and recognising the acceptance of community pharmacists' integration within a multidisciplinary team. Mental health professionals believed that community pharmacists could play a role in reducing the incidence of cardiometabolic adverse events in schizophrenia. However, they underscored the need for enhanced communication and collaboration pathways with other healthcare professionals, emphasised the importance of more comprehensive mental health first aid training, and identified potential barriers for community pharmacists such as remuneration, workload, and staff resources. Conclusions: Mental health professionals acknowledged the benefits of incorporating community pharmacists into multidisciplinary teams as a strategy to reduce the incidence of adverse events among individuals with schizophrenia. They recognise the competence of community pharmacists in monitoring cardiometabolic adverse events. However, these professionals have also highlighted specific perceived barriers to the complete integration of community pharmacists within these teams. Notably, there are concerns related to remuneration, staff resources, time constraints, acceptance by other healthcare professionals and patients, and the need for improved communication pathways. Addressing these barriers and providing targeted training could facilitate the valuable inclusion of community pharmacists in the comprehensive care of people with schizophrenia.
C1 [Karge, Rahnee A.; Curtain, Colin M.; Salahudeen, Mohammed S.] Univ Tasmania, Coll Hlth & Med, Sch Pharm & Pharmacol, Hobart, Tas 7005, Australia.
C3 University of Tasmania
RP Salahudeen, MS (corresponding author), Univ Tasmania, Coll Hlth & Med, Sch Pharm & Pharmacol, Hobart, Tas 7005, Australia.
EM rakarge@utas.edu.au; colin.curtain@utas.edu.au;
   mohammed.salahudeen@utas.edu.au
RI Salahudeen, Mohammed/X-7096-2019
OI Karge, Rahnee/0009-0008-2510-9551
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NR 41
TC 0
Z9 0
U1 0
U2 3
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
SN 1010-660X
EI 1648-9144
J9 MEDICINA-LITHUANIA
JI Med. Lith.
PD DEC
PY 2023
VL 59
IS 12
AR 2052
DI 10.3390/medicina59122052
PG 12
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA DZ5J7
UT WOS:001135928300001
PM 38138155
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Firth, J
   Cotter, J
   Elliott, R
   French, P
   Yung, AR
AF Firth, J.
   Cotter, J.
   Elliott, R.
   French, P.
   Yung, A. R.
TI A systematic review and meta-analysis of exercise interventions in
   schizophrenia patients
SO PSYCHOLOGICAL MEDICINE
LA English
DT Review
DE Exercise; functional recovery; physical activity; psychotic disorders;
   schizophrenia
ID ADD-ON TREATMENT; LIFE-STYLE INTERVENTIONS; INDUCED WEIGHT-GAIN;
   PHYSICAL-ACTIVITY; NEGATIVE SYMPTOMS; CARDIORESPIRATORY FITNESS;
   1ST-EPISODE PSYCHOSIS; ATYPICAL ANTIPSYCHOTICS; AEROBIC EXERCISE;
   EPISODE PATIENTS
AB Background. The typically poor outcomes of schizophrenia could be improved through interventions that reduce cardiometabolic risk, negative symptoms and cognitive deficits; aspects of the illness which often go untreated. The present review and meta-analysis aimed to establish the effectiveness of exercise for improving both physical and mental health outcomes in schizophrenia patients.
   Method. We conducted a systematic literature search to identify all studies that examined the physical or mental effects of exercise interventions in non-affective psychotic disorders. Of 1581 references, 20 eligible studies were identified. Data on study design, sample characteristics, outcomes and feasibility were extracted from all studies and systematically reviewed. Meta-analyses were also conducted on the physical and mental health outcomes of randomized controlled trials.
   Results. Exercise interventions had no significant effect on body mass index, but can improve physical fitness and other cardiometabolic risk factors. Psychiatric symptoms were significantly reduced by interventions using around 90 min of moderate-to-vigorous exercise per week (standardized mean difference: 0.72, 95% confidence interval -1.14 to -0.29). This amount of exercise was also reported to significantly improve functioning, co-morbid disorders and neurocognition.
   Conclusions. Interventions that implement a sufficient dose of exercise, in supervised or group settings, can be feasible and effective interventions for schizophrenia.
C1 [Firth, J.; Cotter, J.; Elliott, R.; Yung, A. R.] Univ Manchester, Inst Brain Behav & Mental Hlth, Manchester M13 9PL, Lancs, England.
   [Elliott, R.] Univ Manchester, Manchester Acad Hlth Sci Ctr, Manchester M13 9PL, Lancs, England.
   [French, P.] Greater Manchester West NHS Mental Hlth Trust, Psychosis Res Unit, Manchester, Lancs, England.
   [French, P.] Univ Liverpool, Inst Psychol Hlth & Soc, Liverpool L69 3BX, Merseyside, England.
   [Yung, A. R.] Univ Melbourne, Orygen Youth Hlth Res Ctr, Melbourne, Vic 3010, Australia.
C3 University of Manchester; University of Manchester; University of
   Liverpool; University of Melbourne; Orygen, The National Centre of
   Excellence in Youth Mental Health
RP Firth, J (corresponding author), Univ Manchester, Room 3-306,Jean McFarlane Bldg,Oxford Rd, Manchester M13 9PL, Lancs, England.
EM joseph.firth@postgrad.manchester.ac.uk
RI Firth, Joseph/JOZ-1679-2023; Yung, Alison/N-6729-2019
OI Elliott, Rebecca/0000-0002-7602-010X; French, Paul/0000-0003-4300-387X;
   Yung, Alison/0000-0002-0401-9791; Firth, Joseph/0000-0002-0618-2752
FU Medical Research Council
FX This research received no specific grant from any funding agency,
   commercial or not-for-profit sectors. J.F. is supported by a Medical
   Research Council Ph.D. Studentship Award.
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NR 79
TC 419
Z9 443
U1 4
U2 141
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0033-2917
EI 1469-8978
J9 PSYCHOL MED
JI Psychol. Med.
PD MAY
PY 2015
VL 45
IS 7
BP 1343
EP 1361
DI 10.1017/S0033291714003110
PG 19
WC Psychology, Clinical; Psychiatry; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA CE6BF
UT WOS:000351920000001
PM 25650668
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Auberval, N
   Dal, S
   Bietiger, W
   Pinget, M
   Jeandidier, N
   Maillard-Pedracini, E
   Schini-Kerth, V
   Sigrist, S
AF Auberval, Nathalie
   Dal, Stephanie
   Bietiger, William
   Pinget, Michel
   Jeandidier, Nathalie
   Maillard-Pedracini, Elisa
   Schini-Kerth, Valerie
   Sigrist, Severine
TI Metabolic and oxidative stress markers in Wistar rats after 2 months on
   a high-fat diet
SO DIABETOLOGY & METABOLIC SYNDROME
LA English
DT Article
DE Metabolic syndrome; High-fat diet; Oxidative stress; Complications
ID INSULIN-RESISTANCE; HEPATIC STEATOSIS; INDUCED OBESITY; ANTIOXIDANT
   ENZYMES; LIVER; MICE; ACCUMULATION; INFLAMMATION; DYSFUNCTION;
   PREVALENCE
AB Background: Metabolic syndrome is associated with an increased risk of cardiovascular and hepatic complications. Oxidative stress in metabolic tissues has emerged as a universal feature of metabolic syndrome and its co-morbidities. We aimed to develop a rapidly and easily induced model of metabolic syndrome in rats to evaluate its impact on plasma and tissue oxidative stress.
   Materials and methods: Metabolic syndrome was induced in rats using a high-fat diet (HFD), and these rats were compared to rats fed a normal diet (ND) for 2 months. Metabolic control was determined by measuring body weight, blood glucose, triglycerides, lipid peroxidation and protein carbonylation in plasma. Insulinemia was evaluated through the measure of C-peptide. Histological analysis was performed on the pancreas, liver and blood vessels.
   Results: After 2 months, the HFD induced an increase in body weight, insulin and triglycerides. Liver steatosis was also observed in the HFD group, which was associated with an increase in glycogen storage. In the pancreas, the HFD induced islet hyperplasia. Tissue oxidative stress was also increased in the liver, pancreas and blood vessels, but plasma oxidative stress remained unchanged.
   Conclusion: This paper reports the development of a fast and easy model of rat metabolic syndrome associated with tissue oxidative stress. This model may be a good tool for the biological validation of drugs or antioxidants to limit or prevent the complications of metabolic syndrome.
C1 [Auberval, Nathalie; Dal, Stephanie; Bietiger, William; Pinget, Michel; Jeandidier, Nathalie; Maillard-Pedracini, Elisa; Sigrist, Severine] Univ Strasbourg, UMR DIATHEC, Federat Med Translat Strasbourg, EA 7294,Ctr Europeen Etud Diabete, F-67200 Strasbourg, France.
   [Pinget, Michel; Jeandidier, Nathalie] HUS, Pole NUDE, F-67000 Strasbourg, France.
   [Schini-Kerth, Valerie] Univ Strasbourg, Dept Pharmacol & Physicochim, UMR 7213, CNRS,Fac Pharm, F-67401 Illkirch Graffenstaden, France.
C3 Universites de Strasbourg Etablissements Associes; Universite de
   Strasbourg; CHU Strasbourg; Centre National de la Recherche Scientifique
   (CNRS); CNRS - National Institute for Biology (INSB); Universites de
   Strasbourg Etablissements Associes; Universite de Strasbourg
RP Sigrist, S (corresponding author), Univ Strasbourg, UMR DIATHEC, Federat Med Translat Strasbourg, EA 7294,Ctr Europeen Etud Diabete, Bld Rene Leriche, F-67200 Strasbourg, France.
EM s.sigrist@ceed-diabete.org
FU foundation "Vaincre le Diabete" and ASDIA (Assistance Service DI Abete)
FX The authors would like to express their gratitude to the foundation
   "Vaincre le Diabete" and ASDIA (Assistance Service DI Abete) for funding
   this project.
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NR 50
TC 53
Z9 59
U1 0
U2 17
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1758-5996
J9 DIABETOL METAB SYNDR
JI Diabetol. Metab. Syndr.
PD NOV 28
PY 2014
VL 6
AR 130
DI 10.1186/1758-5996-6-130
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA AW2CD
UT WOS:000346094900001
PM 25960774
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Ferrero-Hernández, P
   Farias-Valenzuela, C
   Rezende, LFM
   Nascimento, MD
   Marques, A
   de Victo, ER
   Ferrari, G
AF Ferrero-Hernandez, Paloma
   Farias-Valenzuela, Claudio
   Rezende, Leandro F. M.
   Nascimento, Marcelo de Maio
   Marques, Adilson
   de Victo, Eduardo Rossato
   Ferrari, Gerson
TI Combined association of physical activity and depressive symptoms with
   cardiometabolic risk factors in Chilean adults
SO SCIENTIFIC REPORTS
LA English
DT Article
DE Physical activity; Depression; Cardiometabolic risk; Cardiometabolic
   disease; Obesity
ID ACTIVITY QUESTIONNAIRE GPAQ; SEDENTARY BEHAVIOR; HEALTH; PREVALENCE
AB Cardiometabolic risk factors such as obesity, raised blood pressure, high blood glucose and dyslipidemia are emerging health concerns worldwide. Therefore, the aim of this study was to estimate the combined association between physical activity and depressive symptoms with cardiometabolic risk factors in Chilean adults. Data was obtained from the National Health Survey of Chile 2016-2017, with a sample of 5995 adult participants. Assessment of Physical activity and depressive symptoms were done using the Global Physical Activity Questionnaire (GPAQ) and the CIDI ShortForm (CIDI-SF), respectively. Multivariable logistic regression was performed to estimate the combined association of physical activity and depressive symptoms with cardiometabolic risk factors. Participants in the category >= 150 min/Depressive symptoms had the highest prevalence of overweight (OR: 1.55, 95% CI: 1.17-2.05), obesity (OR: 1.97, 95% CI: 1.49-2.59) and high waist circumference (OR: 1.63, 95% CI: 1.39-1.92). Participants in the < 150 min/No depressive symptoms category had a lower prevalence of overweight/obesity (OR: 0.68, 95% CI: 0.60-0.78) and a 25% reduced high triglycerides prevalence, in comparison with the active category with no depressive symptoms. There is a positive association between depressive symptoms and overweight, obesity and waist circumference among subjects that complete physical activity recommendations but have depressive symptoms.
C1 [Ferrero-Hernandez, Paloma; Nascimento, Marcelo de Maio; Ferrari, Gerson] Univ Santiago Chile USACH, Escuela Ciencias Act Fis Deporte & Salud, Santiago, Chile.
   [Farias-Valenzuela, Claudio] Univ San Sebastian, Fac Ciencias Cuidado Salud, Santiago, Chile.
   [Rezende, Leandro F. M.] Univ Fed Sao Paulo, Dept Med Prevent, Escola Paulista Med, Sao Paulo, Brazil.
   [Rezende, Leandro F. M.] Univ Autonoma Chile, Fac Hlth Sci, Providencia, Chile.
   [Nascimento, Marcelo de Maio] Fed Univ Vale Sao Francisco, Dept Phys Educ, Petrolina, Brazil.
   [Marques, Adilson] Univ Lisbon, Fac Motricidade Humana, CIPER, Lisbon, Portugal.
   [Marques, Adilson] Univ Lisbon, Fac Med, ISAMB, Lisbon, Portugal.
   [de Victo, Eduardo Rossato] Univ Fed Sao Paulo, Disciplina Alergia Imunol Clin & Reumatol, Dept Pediat, Escola Paulista Med, Sao Paulo, Brazil.
   [Ferrari, Gerson] Univ Santiago Chile USACH, Escuela Ciencias Act Fis, Deporte & Salud, Sophoras 175,Estac Cent, Santiago, Chile.
C3 Universidad de Santiago de Chile; Universidad San Sebastian;
   Universidade Federal de Sao Paulo (UNIFESP); Universidad Autonoma de
   Chile; Universidade de Lisboa; Universidade de Lisboa; Universidade
   Federal de Sao Paulo (UNIFESP); Universidad de Santiago de Chile
RP Ferrari, G (corresponding author), Univ Santiago Chile USACH, Escuela Ciencias Act Fis Deporte & Salud, Santiago, Chile.; Ferrari, G (corresponding author), Univ Santiago Chile USACH, Escuela Ciencias Act Fis, Deporte & Salud, Sophoras 175,Estac Cent, Santiago, Chile.
EM gerson.demoraes@usach.cl
RI Rezende, Leandro/C-1724-2012; Ferrari, Gerson/HHM-6173-2022; Victo,
   Eduardo/JQI-9333-2023; Marques, Adilson/K-4529-2014; Ferrari,
   Gerson/P-1152-2014
OI Ferrari, Gerson/0000-0003-3177-6576
FU Desarrollo e Innovacin, Universidad de Santiago de Chile
FX We would like to thank the participants from the National Health Survey
   from Chile.
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NR 43
TC 1
Z9 1
U1 1
U2 1
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD DEC 28
PY 2024
VL 14
IS 1
AR 31100
DI 10.1038/s41598-024-82396-6
PG 7
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA R0I7O
UT WOS:001388405400048
PM 39730815
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Nguyen, TTK
   McDonald, C
   Hallahan, B
AF Nguyen, T. T. K.
   McDonald, C.
   Hallahan, B.
TI The association of metabolic syndrome and long acting injectable
   antipsychotics: A systematic review
SO EUROPEAN JOURNAL OF PSYCHIATRY
LA English
DT Review
DE LAI antipsychotics; Metabolic syndrome; Hypertension; Diabetes mellitus;
   Dyslipidaemias
ID PALIPERIDONE PALMITATE; SCHIZOAFFECTIVE DISORDER; OPEN-LABEL;
   2ND-GENERATION ANTIPSYCHOTICS; HALOPERIDOL DECANOATE;
   PSYCHIATRIC-ILLNESS; SCHIZOPHRENIA; RISPERIDONE; DEPOT; OLANZAPINE
AB Background and Objectives: Long-acting injectable (LAI) antipsychotics increase patient adherence, reduce relapse rates and facilitate regular interaction with community mental health teams. Antipsychotics are however associated with adverse effects including metabolic syndrome. This review outlines the rates of monitoring for and rates of metabolic syndrome in patients treated with LAI antipsychotics. Methods: We searched Medline, EMBASE, and Cochrane for Medical Subject Heading (MeSH) terms including metabolic syndrome or MetS and depot or LAI antipsychotics. We included data regarding participants' clinical characteristics, dose and type of antipsychotics administered, rates of monitoring for-and rates of metabolic syndrome and individual metabolic parameters (body mass index or measure of central obesity, blood pressure, lipid levels, plasma glucose and/or HbA1C levels). Results: Six studies were included that evaluated rates of monitoring for-and 39 studies examined rates of metabolic syndrome or individual metabolic parameters. Metabolic parameters were not routinely measured in approximately 75% of patients. Rates of metabolic syndrome ranged between 24.3% and 53.2%, with most studies finding no significant differences between oral and LAIs; however, a more preferable weight and lipid profile was detected with LAIs compared to the oral antipsychotics olanzapine and clozapine. Rates of metabolic syndrome and abnormalities of metabolic parameters were comparable among first-and second-generation and between second-generation LAIs. Conclusions: LAI antipsychotics are associated with high rates of metabolic syndrome but low rates of regular monitoring. A robust screening plan to monitor for metabolic syndrome in individuals treated with LAIs is advised including measurement of individual metabolic parameters. (c) 2022 Asociacion Universitaria de Zaragoza para el Progreso de la Psiquiatria y la Salud Mental. Published by Elsevier Espana, S.L.U. All rights reserved.
C1 [Nguyen, T. T. K.; McDonald, C.; Hallahan, B.] Natl Univ Ireland Galway, Sch Med, Galway, Ireland.
   [Nguyen, T. T. K.] Univ Med & Pharm Ho Chi Minh City, Fac Pharm, Ho Chi Minh City, Vietnam.
   [McDonald, C.; Hallahan, B.] Univ Hosp Galway, Galway Roscommon Mental Hlth Serv, Galway, Ireland.
C3 Ollscoil na Gaillimhe-University of Galway; Hochiminh City University of
   Medicine & Pharmacy; Ollscoil na Gaillimhe-University of Galway
RP Hallahan, B (corresponding author), Natl Univ Ireland, Galway, Ireland.; Hallahan, B (corresponding author), Galway Roscommon Mental Hlth Serv, Galway, Ireland.
EM brian.hallahan@nuigalway.ie
RI McDonald, Colm/C-1430-2009
OI Hallahan, Brian/0000-0003-0518-9757; Nguyen, Kim/0000-0002-5548-0588;
   McDonald, Colm/0000-0003-1661-5192
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NR 69
TC 3
Z9 3
U1 0
U2 4
PU ELSEVIER ESPANA SLU
PI BARCELONA
PA AV JOSEP TARRADELLAS, 20-30, 1ERA PLANTA, BARCELONA, CP-08029, SPAIN
SN 0213-6163
J9 EUR J PSYCHIAT
JI Eur. J. Psychiat.
PD JUL-SEP
PY 2022
VL 36
IS 3
BP 163
EP 175
DI 10.1016/j.ejpsy.2022.01.002
EA JUN 2022
PG 13
WC Psychiatry
WE Social Science Citation Index (SSCI)
SC Psychiatry
GA 2U6OI
UT WOS:000823277200003
DA 2025-06-11
ER

PT J
AU Watson, KT
   Simard, JF
   Henderson, VW
   Nutkiewicz, L
   Lamers, F
   Nasca, C
   Rasgon, N
   Penninx, BWJH
AF Watson, Kathleen T.
   Simard, Julia F.
   Henderson, Victor W.
   Nutkiewicz, Lexi
   Lamers, Femke
   Nasca, Carla
   Rasgon, Natalie
   Penninx, Brenda W. J. H.
TI Incident Major Depressive Disorder Predicted by Three Measures of
   Insulin Resistance: A Dutch Cohort Study
SO AMERICAN JOURNAL OF PSYCHIATRY
LA English
DT Article
ID FORCED SWIMMING TEST; METABOLIC SYNDROME COMPONENTS; PPAR-GAMMA
   RECEPTOR; ALZHEIMERS-DISEASE; SYMPTOMS; ANXIETY; PIOGLITAZONE;
   ASSOCIATION; NETHERLANDS; STRESS
AB Objective: Major depressive disorder is the leading cause of disability worldwide. Yet, there remain significant challenges in predicting new cases of major depression and devising strategies to prevent the disorder. An important first step in this process is identifying risk factors for the incidence of major depression. There is accumulating biological evidence linking insulin resistance, another highly prevalent condition, and depressive disorders. The objectives of this study were to examine whether three surrogate measures of insulin resistance (high triglyceride-HDL [high-density lipoprotein] ratio; prediabetes, as indicated by fasting plasma glucose level; and high central adiposity, as measured by waist circumference) at the time of study enrollment were associated with an increased rate of incident major depressive disorder over a 9-year follow-up period and to assess whether the new onset of these surrogate measures during the first 2 years after study enrollment was predictive of incident major depressive disorder during the subsequent follow-up period.
   Methods: The Netherlands Study of Depression and Anxiety (NESDA) is a multisite longitudinal study of the course and consequences of depressive and anxiety disorders in adults. The study population comprised 601 NESDA participants (18-65 years old) without a lifetime history of depression or anxiety disorders. The study's outcome was incident major depressive disorder, defined using DSM-IV criteria. Exposure measures included triglyceride-HDL ratio, fasting plasma glucose level, and waist circumference.
   Results: Fourteen percent of the sample developed major depressive disorder during follow-up. Cox proportional hazards models indicated that higher triglyceride-HDL ratio was positively associated with an increased risk for incident major depression (hazard ratio=1.89, 95% CI=1.15, 3.11), as were higher fasting plasma glucose levels (hazard ratio=1.37, 95% CI=1.05, 1.77) and higher waist circumference (hazard ratio=1.11 95% CI=1.01, 1.21). The development of prediabetes in the 2-year period after study enrollment was positively associated with incident major depressive disorder (hazard ratio=2.66, 95% CI=1.13, 6.27). The development of high triglyceride-HDL ratio and high central adiposity (cut-point >= 100 cm) in the same period was not associated with incident major depression.
   Conclusions: Three surrogate measures of insulin resistance positively predicted incident major depressive disorder in a 9-year follow-up period among adults with no history of depression or anxiety disorder. In addition, the development of prediabetes between enrollment and the 2-year study visit was positively associated with incident major depressive disorder. These findings may have utility for evaluating the risk for the development of major depression among patients with insulin resistance or metabolic pathology.
C1 [Watson, Kathleen T.; Simard, Julia F.; Henderson, Victor W.] Stanford Sch Med, Dept Epidemiol & Populat Hlth, Stanford, CA 94305 USA.
   [Watson, Kathleen T.; Nutkiewicz, Lexi; Rasgon, Natalie] Stanford Sch Med, Dept Psychiat & Behav Sci, Stanford, CA 94305 USA.
   [Henderson, Victor W.] Stanford Sch Med, Dept Neurol & Neurol Sci, Stanford, CA 94305 USA.
   [Lamers, Femke; Penninx, Brenda W. J. H.] Vrije Univ, Dept Psychiat, Amsterdam UMC, Amsterdam, Netherlands.
   [Lamers, Femke; Penninx, Brenda W. J. H.] Vrije Univ, Amsterdam Publ Hlth Res Inst, Amsterdam UMC, Amsterdam, Netherlands.
   [Nasca, Carla] Rockefeller Univ, Harold & Margaret Milliken Hatch Lab Neuroendocri, 1230 York Ave, New York, NY 10021 USA.
C3 Stanford University; Stanford University; Stanford University;
   University of Amsterdam; Vrije Universiteit Amsterdam; Vrije
   Universiteit Amsterdam; University of Amsterdam; Rockefeller University
RP Watson, KT (corresponding author), Stanford Sch Med, Dept Epidemiol & Populat Hlth, Stanford, CA 94305 USA.; Watson, KT; Rasgon, N (corresponding author), Stanford Sch Med, Dept Psychiat & Behav Sci, Stanford, CA 94305 USA.
EM nrasgon@stanford.edu
RI Henderson, V/AAW-4744-2021; Lamers, Femke/G-5161-2012; Penninx,
   Brenda/S-7627-2017
OI Henderson, Victor/0000-0003-1198-9240
FU Brain and Behavior Research Foundation; Geestkracht program of the
   Netherlands Organization for Health Research and Development (ZonMw)
   [10-000-1002]; Pritzker Neuropsychiatric Disorders Research Consortium
FX Dr. Nasca was supported in part by a 2019 NARSAD Young Investigator
   grant from the Brain and Behavior Research Foundation. The
   infrastructure for the Netherlands Study of Depression and Anxiety
   (www.nesda.nl) is funded through the Geestkracht program of the
   Netherlands Organization for Health Research and Development (ZonMw,
   grant 10-000-1002) and financial contributions by participating
   universities and mental health care organizations (Amsterdam University
   Medical Centers, GGZ inGeest, Leiden University Medical Center, Leiden
   University, GGZ Rivierduinen, University Medical Center Groningen,
   University of Groningen, Lentis, GGZ Friesland, GGZ Drenthe, and Rob
   Giel Onderzoekscentrum). Supported by the Pritzker Neuropsychiatric
   Disorders Research Consortium.
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NR 50
TC 65
Z9 72
U1 1
U2 15
PU AMER PSYCHIATRIC PUBLISHING, INC
PI WASHINGTON
PA 800 MAINE AVE SW, SUITE 900, WASHINGTON, DC 20024 USA
SN 0002-953X
EI 1535-7228
J9 AM J PSYCHIAT
JI Am. J. Psychiat.
PD OCT
PY 2021
VL 178
IS 10
BP 914
EP 920
DI 10.1176/appi.ajp.2021.20101479
PG 7
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA WC5XN
UT WOS:000704331100008
PM 34551583
DA 2025-06-11
ER

PT J
AU López, ALL
   Villanueva, MCE
   Padilla, MB
   Jaime, HB
   Aguilar, FJA
AF Lopez Lopez, A. L.
   Escobar Villanueva, M. C.
   Brianza Padilla, M.
   Bonilla Jaime, H.
   Alarcon Aguilar, F. J.
TI CHRONIC UNPREDICTABLE MILD STRESS PROGRESSIVELY DISTURBS GLUCOSE
   METABOLISM AND APPETITE HORMONES IN RATS
SO ACTA ENDOCRINOLOGICA-BUCHAREST
LA English
DT Article
DE stress; insulin; ghrelin; Leptin; chronic stress; metabolism alterations
ID CHRONIC PSYCHOLOGICAL STRESS; IMMOBILIZATION STRESS; FOOD-INTAKE;
   CORTISOL; BEHAVIOR; GHRELIN; INSULIN; LEPTIN; CORTICOSTERONE; EXPOSURE
AB Context. Chronic stress is characterized by increased release of catecholamines, glucocorticoids and other neurohumoral factors, predisposing individuals to obesity, insulin resistance and vascular disease, pathologies considered priority health problems. Study of alterations induced by stress on metabolism in association with food intake modulatory hormones (insulin, leptin and ghrelin) is mandatory.
   Objective. This research studied temporal course during 60 days of chronic unpredictable mild stress (CUMS) on glucose and lipids metabolism, and on the neuroendocrine system that regulates appetite-satiety balance.
   Materials and Methods. Wistar rats were exposed to CUMS for 20, 40 and 60 days. Corticosterone stayed high during 60 days of CUMS; after 40 days, body weight, cholesterol and triglycerides decreased and glucose intolerance was evident at day 60; insulin and ghrelin increased at 20 and 40 days, respectively; leptin decreased after day 20. Data suggest that 60 days of CUMS progressively disturb metabolism of carbohydrates and lipids as well as food intake regulatory hormones, affecting the metabolism, and can lead to the development of chronic degenerative diseases, such as cardiovascular disease, metabolic syndrome and type 2 diabetes.
C1 [Lopez Lopez, A. L.] Univ Autonoma Baja California, Fac Nursing, Mexicali, Baja California, Mexico.
   [Escobar Villanueva, M. C.; Alarcon Aguilar, F. J.] Univ Autonoma Metropolitana Iztapalapa, DCBS, Dept Hlth Sci, Lab Pharmacol, Mexico City, DF, Mexico.
   [Brianza Padilla, M.; Bonilla Jaime, H.] Univ Autonoma Metropolitana Iztapalapa, DCBS, Dept Reprod Biol, Lab Reprod Pharmacol, Mexico City, DF, Mexico.
C3 Universidad Autonoma de Baja California; Universidad Autonoma
   Metropolitana - Mexico; Universidad Autonoma Metropolitana - Mexico
RP Aguilar, FJA (corresponding author), Univ Autonoma Metropolitana Iztapalapa, Ciencias Salud, San Rafael Atlixco 186, Cdmx 09340, Iztapalapa, Mexico.
EM aaaf@xanum.uam.mx
RI BRIANZA- PADILLA, MALINALLI/JZE-1593-2024
OI Brianza-Padilla, Malinalli/0000-0002-0238-8278; Brianza-Padilla,
   Malinalli/0000-0002-0089-4775
FU Universidad Autonoma Metropolitana-Iztapalapa; CONACyT; PRODEP-SEP
FX This work was supported by the Universidad Autonoma
   Metropolitana-Iztapalapa, CONACyT and PRODEP-SEP.
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NR 40
TC 25
Z9 26
U1 0
U2 20
PU EDITURA ACAD ROMANE
PI BUCURESTI
PA CALEA 13 SEPTEMBRIE NR 13, SECTOR 5, BUCURESTI 050711, ROMANIA
SN 1841-0987
EI 1843-066X
J9 ACTA ENDOCRINOL-BUCH
JI Acta Endocrinol.
PD JAN-MAR
PY 2018
VL 14
IS 1
BP 16
EP 23
DI 10.4183/aeb.2018.16
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA GF1UX
UT WOS:000431722200003
PM 31149231
OA Green Published
DA 2025-06-11
ER

EF﻿FN Clarivate Analytics Web of Science
VR 1.0
PT J
AU Li, YM
   Zhao, SY
   Zhao, HH
   Wang, BH
   Li, SM
AF Li, Yi-Ming
   Zhao, Shao-Yang
   Zhao, Huan-Huan
   Wang, Bao-Hua
   Li, Sai-Mei
TI Procyanidin B2 Alleviates Palmitic Acid-Induced Injury in HepG2 Cells
   via Endoplasmic Reticulum Stress Pathway
SO EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Article
ID FATTY LIVER-DISEASE; LIPID-ACCUMULATION; DRUG DISCOVERY; LIPOTOXICITY
AB Nonalcoholic fatty liver disease (NAFLD) is the hepatic manifestation of the metabolic syndrome featuring ectopic lipid accumulation in hepatocytes. NAFLD has been a severe threat to humans with a global prevalence of over 25% yet no approved drugs for the treatment to date. Previous studies showed that procyanidin B2 (PCB2), an active ingredient from herbal cinnamon, has an excellent hepatoprotective effect; however, the mechanism remains inconclusive. The present study aimed to investigate the protective effect and underlying mechanism of PCB2 on PA-induced cellular injury in human hepatoma HepG2 cells. Our results showed that PA-induced oxidative stress, calcium disequilibrium, and subsequent endoplasmic reticulum stress (ERS) mediated cellular injury, with elevated protein levels of GRP78, GRP94, CHOP, and hyperphosphorylation of PERK and IRE1 alpha as well as the increased ratio of Bax/Bcl-2, which was restored by PCB2 in a concentration-dependent manner, proving the excellent antiapoptosis effect. In addition, 4-phenylbutyric acid (4-PBA), the ER stress inhibitor, increased cell viability and decreased protein levels of GRP78 and CHOP, which is similar to PCB2, and thapsigargin (TG), the ER stress agonist, exhibited conversely meanwhile partly counteracted the hepatic protection of PCB2. What is more, upregulated protein expression of p-IKK alpha/beta, p-NF-kappa B p65, NLRP3, cleaved caspase 1, and mature IL-1 beta occurred in HepG2 cells in response to PA stress while rescued with the PCB2 intervention. In conclusion, our study demonstrated that PA induces ERS in HepG2 cells and subsequently activates downstream NLRP3 inflammasome-mediated cellular injury, while PCB2 inhibits NLRP3/caspase 1/IL-1 beta pathway, inflammation, and apoptosis with the presence of ERS, thereby promoting cell survival, which may provide pharmacological evidence for clinical approaches on NAFLD.
C1 [Li, Yi-Ming; Zhao, Shao-Yang; Wang, Bao-Hua; Li, Sai-Mei] Guangzhou Univ Chinese Med, Sch Clin Med 1, Guangzhou 510000, Peoples R China.
   [Zhao, Shao-Yang; Wang, Bao-Hua; Li, Sai-Mei] Guangzhou Univ Chinese Med, Affiliated Hosp 1, Guangzhou 510000, Peoples R China.
   [Zhao, Huan-Huan] Linyi Peoples Hosp, Nutr Dept, Linyi 276000, Shandong, Peoples R China.
C3 Guangzhou University of Chinese Medicine; Guangzhou University of
   Chinese Medicine
RP Wang, BH; Li, SM (corresponding author), Guangzhou Univ Chinese Med, Sch Clin Med 1, Guangzhou 510000, Peoples R China.; Wang, BH; Li, SM (corresponding author), Guangzhou Univ Chinese Med, Affiliated Hosp 1, Guangzhou 510000, Peoples R China.
EM wangbaohua@gzucm.edu.cn; lsm@gzucm.edu.cn
OI Li, Yiming/0000-0001-9475-2374; Zhao, Shao-Yang/0000-0001-8521-0223;
   Zhao, Huanhuan/0000-0002-5274-5595
FU National Natural Science Foundation of China for Youth [82104621,
   82104791]; Collaborative Innovation Team Construction Project of
   Guangzhou University of Chinese Medicine [2021XK15]
FX The authors are grateful to the Lingnan Medical Research Center,
   Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province,
   China, for the assistance. This study was supported by the National
   Natural Science Foundation of China for Youth (Nos. 82104621 and
   82104791) and Collaborative Innovation Team Construction Project of
   Guangzhou University of Chinese Medicine (No. 2021XK15).
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NR 40
TC 8
Z9 11
U1 0
U2 14
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1741-427X
EI 1741-4288
J9 EVID-BASED COMPL ALT
JI Evid.-based Complement Altern. Med.
PD DEC 16
PY 2021
VL 2021
AR 8920757
DI 10.1155/2021/8920757
PG 14
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA YU1PW
UT WOS:000751822400006
PM 34956386
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Abd El-Kader, SM
   Al-Dahr, MHS
AF Abd El-Kader, Shehab M.
   Al-Dahr, Mohammed H. Saiem
TI Impact of weight loss on oxidative stress and inflammatory cytokines in
   obese type 2 diabetic patients
SO AFRICAN HEALTH SCIENCES
LA English
DT Article
DE Type 2 diabetes; weight reduction; oxidative stress; cytokines; obesity
ID INSULIN-RESISTANCE; RISK-FACTORS; EXERCISE INTERVENTION; METABOLIC
   SYNDROME; ADIPOSE-TISSUE; DIET; ADIPONECTIN; MARKERS; WOMEN; DYSFUNCTION
AB Background: Type 2 diabetes mellitus is associated with abnormal markers of inflammatory cytokines and oxidative stress markers. Although, these abnormalities could be modulated with weight reduction; there is limitation in clinical studies that have addressed the beneficial effects of weight reduction in modulating biomarkers of inflammatory cytokines and oxidative stress for obesity associated with type 2 diabetes mellitus.
   Objective: This study was designed to detect the effects of weight loss on the inflammatory cytokines, oxidative stress markers in obese type 2 diabetic patients.
   Material and Methods: Eighty obese patients with type 2 diabetes mellitus, their age ranged from 35-57 years and their body mass index ranged from 31-35 kg/m(2) were equally assigned into 2 groups: the weight reduction group received aerobic exercises, diet regimen, where as the control group received medical treatment only for 12 weeks.
   Results: The mean values of body mass index (BMI), tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), C-reactive protein (sCRP), conjugated dienes (CD) and malondialdehyde (MDA) were significantly decreased, while the mean values of glutathione peroxidase (GPx), superoxide dismutase (SOD) and glutathione (GSH) were significantly increased in patients of group (A), while changes were not significant in group (B). Also, there were significant differences between mean levels of the investigated parameters in group (A) and group (B) at the end of the study.
   Conclusion: Weight loss ameliorates inflammatory cytokines and oxidative stress markers in obese type 2 diabetic patients.
C1 [Abd El-Kader, Shehab M.] King Abdulaziz Univ, Fac Appl Med Sci, Dept Phys Therapy, POB 80324, Jeddah 21589, Saudi Arabia.
   [Al-Dahr, Mohammed H. Saiem] King Abdulaziz Univ, Fac Appl Med Sci, Dept Lab Med, Jeddah, Saudi Arabia.
C3 King Abdulaziz University; King Abdulaziz University
RP Abd El-Kader, SM (corresponding author), King Abdulaziz Univ, Fac Appl Med Sci, Dept Phys Therapy, POB 80324, Jeddah 21589, Saudi Arabia.
EM salmuzain@kau.edu.sa
RI El-Kader, Shehab/J-4047-2013
FU Deanship of Scientific Research (DSR), King Abdulaziz University, Jeddah
   [142/4/D1436]; DSR
FX This project was funded by the Deanship of Scientific Research (DSR),
   King Abdulaziz University, Jeddah, under grant no. (142/4/D1436). The
   authors, therefore, acknowledge with thanks DSR technical and financial
   support.
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NR 51
TC 26
Z9 26
U1 0
U2 5
PU MAKERERE UNIV, FAC MED
PI KAMPALA
PA PO BOX 7072, KAMPALA, 00000, UGANDA
SN 1680-6905
EI 1729-0503
J9 AFR HEALTH SCI
JI Afr. Health Sci.
PY 2016
VL 16
IS 3
BP 725
EP 733
DI 10.4314/ahs.v16i3.12
PG 9
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA EC4OP
UT WOS:000388112800012
PM 27917205
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Schincaglia, RM
   Cuppari, L
   Neri, HFS
   Cintra, DE
   Sant'Ana, MR
   Mota, JF
AF Schincaglia, Raquel M.
   Cuppari, Lilian
   Neri, Hiasmin F. S.
   Cintra, Dennys E.
   Sant'Ana, Marcella R.
   Mota, Joao F.
TI Effects of baru almond oil (Dipteryx alata Vog.) supplementation
   on body composition, inflammation, oxidative stress, lipid profile, and
   plasma fatty acids of hemodialysis patients: A randomized, double-blind,
   placebo-controlled clinical trial
SO COMPLEMENTARY THERAPIES IN MEDICINE
LA English
DT Article
DE Dipteryx alata Vog.; Body composition; Inflammation; Oxidative stress;
   Lipid profile
ID BRAZIL NUT SUPPLEMENTATION; C-REACTIVE PROTEIN; METABOLIC SYNDROME;
   DISEASE PATIENTS; RENAL-FAILURE; CONSUMPTION; CHOLESTEROL; MARKERS;
   SEEDS; BIOMARKERS
AB Background: The consumption of nuts and edible seeds is associated with the improvement of the metabolic profile and reduction of cardiovascular diseases. However, the effects of its subproducts, such as oil, are still poorly studied. This study aimed to evaluate the effect of the baru almond oil supplementation on inflammation, oxidative stress, body composition, lipid profile, and plasma fatty acids of hemodialysis patients.
   Methods: In a randomized, double-blind, 12-week placebo-controlled clinical study, hemodialysis patients were supplemented with 5 g of baru oil (BG, n = 17) or 5 g of mineral oil (placebo, BP, n = 12). Body composition, renal function, ultra-sensitive C-reactive protein (us-CRP), oxidative stress, plasma fatty acids, and lipid profile were analysed before and after the intervention.
   Results: Patients were aged 50.5 +/- 2.2 years and the average time of dialyses was 52,1 +/- 42,6 months. The BG decreased us-CRP concentration compared to PG (-1.2 +/- 0.2 vs. + 0.8 +/- 0.2 mg / L,d = 0.88; p = 0.01). Baru almond oil supplementation was not effective in improving body composition, lipid profile, and oxidative stress.
   Conclusion: Baru almond oil supplementation decreased us-CRP concentration in patients with chronic kidney disease under hemodialysis treatment.
C1 [Schincaglia, Raquel M.; Mota, Joao F.] Univ Fed Goias UFG, Fac Nutr, Lab Invest Nutr Clin & Exercicio Labince, BR-74605080 Goiania, Go, Brazil.
   [Cuppari, Lilian] Univ Fed Sao Paulo, Dept Nefrol, BR-04021001 Sao Paulo, SP, Brazil.
   [Cuppari, Lilian] Fundacao Oswaldo Ramos, BR-04021001 Sao Paulo, SP, Brazil.
   [Neri, Hiasmin F. S.] Univ Fed Goias UFG, Dept Farmacol, Inst Ciencias Biol, Lab Farmacol Bioquim & Mol, BR-74690090 Goiania, Go, Brazil.
   [Cintra, Dennys E.; Sant'Ana, Marcella R.] Univ Estadual Campinas UNICAMP, Fac Ciencias Aplicadas, Lab Genom Nutr LabGeN, BR-13484350 Limeira, SP, Brazil.
C3 Universidade Federal de Sao Paulo (UNIFESP); Universidade Estadual de
   Campinas
RP Mota, JF (corresponding author), Univ Fed Goias UFG, Fac Nutr, Lab Invest Nutr Clin & Exercicio Labince, BR-74605080 Goiania, Go, Brazil.
EM joao_mota@ufg.br
RI Cuppari, Lilian/C-3394-2012; Mota, João/AAU-9194-2020; Cintra,
   Dennys/N-7758-2017
OI Schincaglia, Raquel/0000-0002-8450-6775
FU Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior - Brazil
   (CAPES) [001 (23038.014292/2018-73)]; National Council for Scientific
   and Technological Development (CNPq) [305082/2019-1]
FX This study was financed in part by the Coordenacao de Aperfeicoamento de
   Pessoal de Nivel Superior - Brazil (CAPES) Finance Code 001
   (23038.014292/2018-73). Joao Felipe Mota has been financially supported
   by the National Council for Scientific and Technological Development
   (CNPq, number 305082/2019-1).
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NR 55
TC 17
Z9 19
U1 0
U2 5
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0965-2299
EI 1873-6963
J9 COMPLEMENT THER MED
JI Complement. Ther. Med.
PD AUG
PY 2020
VL 52
AR 102479
DI 10.1016/j.ctim.2020.102479
PG 8
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA OA1IW
UT WOS:000577549300033
PM 32951729
DA 2025-06-11
ER

PT J
AU Yavuz, BB
   Yavuz, B
   Halil, M
   Cankurtaran, M
   Ulger, Z
   Cankurtaran, ES
   Aytemir, K
   Ariogul, S
AF Yavuz, Burcu Balam
   Yavuz, Bunyamin
   Halil, Meltem
   Cankurtaran, Mustafa
   Ulger, Zekeriya
   Cankurtaran, Eylem Sahin
   Aytemir, Kudret
   Ariogul, Serviet
TI Serum elevated gamma glutamyltransferase levels may be a marker for
   oxidative stress in Alzheimer's disease
SO INTERNATIONAL PSYCHOGERIATRICS
LA English
DT Article
DE Alzheimer's disease; gamma glutamyltransferase; marker; oxidative
   stress; vascular risk factor
ID MILD COGNITIVE IMPAIRMENT; GLUTAMYL-TRANSFERASE ACTIVITY; METABOLIC
   SYNDROME; VASCULAR-DISEASE; DEMENTIA; PLASMA; RISK; ATHEROSCLEROSIS;
   ANTIOXIDANTS; TRANSPEPTIDASE
AB Background: Gamma glutamyltransferase (GGT) plays a role in cellular glutathione uptake, which is an important element of antioxidant mechanisms. An increase in serum GGT is thought to be an early and sensitive marker of oxidative stress. Oxidative stress has a role in the pathogenesis of Alzheimer's disease (AD). The aim of this study was to investigate the GGT levels in AD.
   Method: In this cross-sectional study, 132 patients with AD (mean age: 74.1 +/- 7.4, female 62.9%) and 158 age- and gender-matched normal controls (mean age: 74.5 +/- 6.3, female 67.1%) were evaluated. For cognitive assessment, MMSE and clock drawing tests were performed; DSM-IV and NINCDS-ADRDA criteria were used. Serum GGT, aspartate aminotransferase, alanine aminotransferase and alkaline phosphatase concentrations were determined.
   Results: Median (min-max) GGT levels were 18 (9-70) in AD group and 17 (5-32) in normal controls. Mann-Whitney U test showed that GGT levels were significantly higher in AD patients (p = 0.012). Linear regression analysis revealed AD was an independent correlate of elevated GGT levels. Hypertension, diabetes mellitus, total cholesterol, and low density lipoprotein cholesterol were not associated with GGT levels.
   Conclusion: GGT levels were increased significantly in AD patients. To evaluate the role of GGT as a marker of oxidative stress in AD, further studies are needed.
C1 [Yavuz, Burcu Balam; Halil, Meltem; Cankurtaran, Mustafa; Ulger, Zekeriya; Ariogul, Serviet] Hacettepe Univ, Fac Med, Dept Internal Med, Div Geriatr Med, TR-06100 Ankara, Turkey.
   [Yavuz, Bunyamin] Kecioren Res Hosp, Dept Cardiol, Ankara, Turkey.
   [Cankurtaran, Eylem Sahin] Ankara Oncol Hosp, Dept Psychiat, Ankara, Turkey.
   [Aytemir, Kudret] Hacettepe Univ, Fac Med, Dept Cardiol, TR-06100 Ankara, Turkey.
C3 Hacettepe University; Ankara Kecioren Training & Research Hospital; Dr.
   Abdurrahman Yurtaslan Oncology Hospital; Hacettepe University
RP Yavuz, BB (corresponding author), Hacettepe Univ, Fac Med, Dept Internal Med, Div Geriatr Med, TR-06100 Ankara, Turkey.
EM bbyavuz@hacettepe.edu.tr
RI HALIL, MELTEM/I-9038-2013; YAVUZ, BURCIN/J-1044-2013
OI Halil, Meltem Gulhan/0000-0001-7597-8140; Dogu, Burcu
   Balam/0000-0002-4430-6146; Cankurtaran, Mustafa/0000-0002-8213-7515
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NR 41
TC 26
Z9 29
U1 0
U2 11
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
SN 1041-6102
EI 1741-203X
J9 INT PSYCHOGERIATR
JI Int. Psychogeriatr.
PD AUG
PY 2008
VL 20
IS 4
BP 815
EP 823
DI 10.1017/S1041610208006790
PG 9
WC Psychology, Clinical; Geriatrics & Gerontology; Gerontology; Psychiatry;
   Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Geriatrics & Gerontology; Psychiatry
GA 352EN
UT WOS:000259478300015
PM 18416873
OA hybrid
DA 2025-06-11
ER

PT J
AU Chen, BY
   Wei, JG
   Wang, W
   Cui, GB
   Zhao, YF
   Zhu, XX
   Zhu, MZ
   Guo, W
   Yu, J
AF Chen, Baoying
   Wei, Jingguo
   Wang, Wei
   Cui, Guangbin
   Zhao, Yufeng
   Zhu, Xiaoxing
   Zhu, Miaozhang
   Guo, Wei
   Yu, Jun
TI Identification of Signaling Pathways Involved in Aberrant Production of
   Adipokines in Adipocytes Undergoing Oxidative Stress
SO ARCHIVES OF MEDICAL RESEARCH
LA English
DT Article
DE Oxidative stress; Adipocyte; Obesity; Adiponectin; Plasminogen activator
   inhibitor-1; Interleukin-6
ID PLASMINOGEN-ACTIVATOR INHIBITOR-1; ADIPOSE-TISSUE; METABOLIC SYNDROME;
   CARDIOVASCULAR-DISEASE; HEAT-SHOCK; ADIPONECTIN; OBESITY; PROTEIN;
   PHOSPHORYLATION; INTERLEUKIN-6
AB Background and Aims. In obesity, oxidative stress is responsible for the aberrant production of adipokines such as adiponectin, plasminogen activator inhibitor (PAI)-1 and interleukin-6 (IL-6), which is causally associated with obesity-related inflammation, insulin resistance and cardiovascular disease. However, the signaling transduction pathways participating in adipokine dysregulation induced by oxidative stress are largely unknown. Thus, the aim of the present study was to identify possible involved signaling pathways.
   Methods. 3T3-L1 cells were differentiated into adipocytes and underwent oxidative stress by exposure to extraneous H2O2. Quantitative PCR and immunoassays were performed to determine mRNA and protein levels of adipokines (adiponectin, PAI-1 and IL-6), respectively. Possible signaling pathways involved were high-throughout identified by Bioplex phosphoprotein assays and subsequently confirmed by inhibition of the targeted protein kinases such as Akt, ERK1/2, JAK/STAT, JNK, and p70 S6 K, respectively.
   Results. H2O2 markedly suppressed adiponectin mRNA expression as well as protein secretion; however, it enhanced PAI-1 and IL-6 production in mature adipocytes. Akt, JAK/STAT and ERK1/2 participated in the H2O2-induced increase of PAI-1 and IL-6 expression, whereas adiponectin expression was reduced by H2O2 via Akt and JAK/STAT.
   Conclusions. Akt and JAK/STAT are congenerous pathways through which oxidative stress downregulates adiponectin and upregulates PAI-1 and IL-6 expression. ERK1/2 participates not in H2O2-induced decrease of adiponectin expression, but in the increase of PAI-1 and IL-6. (C) 2009 IMSS. Published by Elsevier Inc.
C1 [Yu, Jun] Fourth Mil Med Univ, Preclin Expt Ctr, Xian 710032, Shaanxi, Peoples R China.
   [Chen, Baoying; Wei, Jingguo; Wang, Wei; Cui, Guangbin; Guo, Wei] Fourth Mil Med Univ, Dept Radiol, Tangdu Hosp, Xian 710032, Shaanxi, Peoples R China.
   [Zhao, Yufeng; Zhu, Miaozhang] Fourth Mil Med Univ, Dept Physiol, Xian 710032, Shaanxi, Peoples R China.
   [Zhu, Xiaoxing] Fourth Mil Med Univ, Dept Pharmacol, Xian 710032, Shaanxi, Peoples R China.
C3 Air Force Medical University; Air Force Medical University; Air Force
   Medical University; Air Force Medical University
RP Yu, J (corresponding author), Fourth Mil Med Univ, Preclin Expt Ctr, 169 Changle W Rd, Xian 710032, Shaanxi, Peoples R China.
EM pclamper@163.com
RI Yang, Chi/JRY-4671-2023
FU Chinese Natural Science Fund [30801385]
FX This work was supported by the Chinese Natural Science Fund (No.
   30801385). We are grateful to Prof. K.S. Lam for providing DN-Akt and
   control adenovirus vectors.
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NR 26
TC 32
Z9 35
U1 0
U2 5
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0188-4409
EI 1873-5487
J9 ARCH MED RES
JI Arch. Med. Res.
PD MAY
PY 2009
VL 40
IS 4
BP 241
EP 248
DI 10.1016/j.arcmed.2009.03.007
PG 8
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 483GO
UT WOS:000268951200003
PM 19608012
DA 2025-06-11
ER

PT J
AU Gao, SY
   Han, X
   Fu, JH
   Yuan, XL
   Sun, X
   Li, Q
AF Gao, Siyuan
   Han, Xue
   Fu, Jihua
   Yuan, Xiaoling
   Sun, Xing
   Li, Qiang
TI Influence of chronic stress on the compositions of hepatic cholesterol
   and triglyceride in male Wistar rats fed a high fat diet
SO HEPATOLOGY RESEARCH
LA English
DT Article
DE chronic stress; hepatic lipidosis; high fat diet; water-soluble parts of
   hepatic cholesterol; water-soluble parts of hepatic triglyceride
ID METABOLIC SYNDROME; LIVER; HEPATOCYTES; CONTRIBUTES; SECRETION; SYSTEM;
   GAMMA; PPAR; OIL
AB Aim: We determined the influence of chronic stress (CS) on the compositions of hepatic cholesterol and triglyceride (TG) in rats fed a high fat diet (HFD). Methods: Male Wistar rats were fed either a standard diet or a HFD and half of the HFD fed rats were given CS (electric foot shock assisted with noise) for 8 weeks. Results: Compared with the control group, the levels of hepatic total cholesterol (TC) and TG were significantly elevated in the HFD and HFD with chronic stress (HFD+CS) groups, and the more severe elevations of them were found in the HFD group. Inversely, the more severe elevations of hepatic water-soluble parts of TC and TG were found in the HFD+CS group, as the elevations of low-density lipoprotein cholesterol, very low-density lipoprotein cholesterol in liver and serum, tumor necrosis factor-a, interleukin-1 beta and malondialdehyde in liver. Meanwhile, downregulated mRNA expressions of hepatic liver X receptor-a (LXR-a) and peroxisome proliferator-activated receptor-? (PPAR-?) were also more severe in the HFD+CS group. Conclusion: CS can aggravate the high levels of water-soluble compositions of hepatic TC and TG induced by HFD as it aggravates hepatic inflammation and oxidative stress; in spite of that, however, it cannot further promote hepatic lipidosis. This is consistent with the downregulated mRNA expressions of LXR-a and PPAR-?.
C1 [Gao, Siyuan; Han, Xue; Fu, Jihua; Yuan, Xiaoling; Sun, Xing; Li, Qiang] China Pharmaceut Univ, Dept Physiol, Nanjing 211198, Jiangsu, Peoples R China.
C3 China Pharmaceutical University
RP Fu, JH (corresponding author), China Pharmaceut Univ, Dept Physiol, 639 Long Mian Rd, Nanjing 211198, Jiangsu, Peoples R China.
EM fjhn@sohu.com
CR Barakat HA, 1996, J NUTR BIOCHEM, V7, P586, DOI 10.1016/S0955-2863(96)00117-9
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NR 28
TC 6
Z9 6
U1 0
U2 9
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1386-6346
J9 HEPATOL RES
JI Hepatol. Res.
PD JUL
PY 2012
VL 42
IS 7
BP 686
EP 695
DI 10.1111/j.1872-034X.2011.00961.x
PG 10
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 956ZR
UT WOS:000305128600008
PM 22321167
DA 2025-06-11
ER

PT J
AU Wiernik, E
   Lemogne, C
   Fezeu, L
   Arnault, N
   Hercberg, S
   Kesse-Guyot, E
   Galan, P
AF Wiernik, Emmanuel
   Lemogne, Cedric
   Fezeu, Leopold
   Arnault, Nathalie
   Hercberg, Serge
   Kesse-Guyot, Emmanuelle
   Galan, Pilar
TI Association Between Alexithymia and Risk of Incident Cardiovascular
   Diseases in the SUpplementation en VItamines et Mineraux AntioXydants
   (SU.VI.MAX) Cohort
SO PSYCHOSOMATIC MEDICINE
LA English
DT Article
DE alexithymia; cardiovascular diseases; epidemiology; longitudinal studies
ID HIGH BLOOD-PRESSURE; OCCUPATIONAL-STATUS; PERCEIVED STRESS;
   MYOCARDIAL-INFARCTION; METABOLIC SYNDROME; VALIDATION; PREVENTION;
   DEPRESSION; STROKE
AB Objective Although it has been suggested that alexythymia is associated with cardiovascular diseases, studies are scarce and a causal relationship is questionable. This study explored the prospective association between alexithymia and cardiovascular events in middle-aged participants without cardiovascular history at baseline.
   Methods The 26-item Toronto Alexithymia Scale (TAS-26) was completed by 5586 participants of the French SUpplementation en VItamines et Mineraux AntioXydants cohort (41.4% of men, M [SD] age = 52.2 [6.3] years) in 1996-1997. Covariates measured at baseline included age, occupational status, depressive symptoms, smoking status, body mass index, hypertension, diabetes, hypercholesterolemia, and hypertriglyceridemia. The follow-up ran from January 1, 1998, to the date of the first cardiovascular event, the date of death or September 1, 2007, whichever occurred first. Cardiovascular events were validated by an independent expert committee. Hazard ratios and 95% confidence intervals were computed with Cox regressions.
   Results During an average of 8.9 years of follow-up, 171 first cardiovascular events were validated. After adjustment for age, sex, and occupational status, there was no association between baseline alexithymia and cardiovascular events at follow-up (hazard ratio [95% confidence interval] for 15 points of TAS-26 = 1.00 [0.81-1.23], p > .99). Adjusting for all covariates, using binary TAS-26 cut-offs or TAS-26 subscores yielded similar nonsignificant results.
   Conclusions In this large prospective study, alexithymia and cardiovascular events were not associated among a nonclinical population. This casts some doubt on whether alexithymia could be a meaningful target in the prevention of cardiovascular diseases.
   Clinical Trial Registration Clinicaltrials.gov (NCT00272428).
C1 [Wiernik, Emmanuel; Lemogne, Cedric] Univ Paris 05, Sorbonne Paris Cite, Fac Med, Paris, France.
   [Wiernik, Emmanuel; Lemogne, Cedric] Inserm, Ctr Psychiat & Neurosci, U894, 102 Rue Sante, F-75014 Paris, France.
   [Lemogne, Cedric] Hop Univ Paris Ouest, Serv Psychiat Adulte & Sujet Age, AP HP, Paris, France.
   [Fezeu, Leopold; Arnault, Nathalie; Hercberg, Serge; Kesse-Guyot, Emmanuelle; Galan, Pilar] Univ Paris 13, Ctr Rech Epidemiol & Stat, Sorbonne Paris Cite, EREN,Inserm,Inra,Cnam,COMUE,SMBH,U1153,U1125, Bobigny, France.
   [Hercberg, Serge] Hop Avicenne, Dept Sante Publ, Bobigny, France.
C3 Universite Paris Cite; Universite Paris Cite; Institut National de la
   Sante et de la Recherche Medicale (Inserm); Assistance Publique Hopitaux
   Paris (APHP); Universite Paris Cite; Hopital Universitaire Europeen
   Georges-Pompidou - APHP; heSam Universite; Conservatoire National Arts &
   Metiers (CNAM); INRAE; Universite Paris 13; Institut National de la
   Sante et de la Recherche Medicale (Inserm); Universite Paris Cite;
   Assistance Publique Hopitaux Paris (APHP); Hopital Universitaire
   Avicenne - APHP; Universite Paris 13
RP Wiernik, E (corresponding author), Inserm, Ctr Psychiat & Neurosci, U894, 102 Rue Sante, F-75014 Paris, France.
EM emmanuel.wiernik@inserm.fr
RI Serge, Hercberg/F-3038-2017; Kesse-Guyot, Emmanuelle/F-2692-2017; Pilar,
   Galan/F-2908-2017; Lemogne, Cédric/Q-6091-2019; Wiernik,
   Emmanuel/AAD-5519-2019
OI Wiernik, Emmanuel/0000-0001-8046-7919
FU Societe Francaise d'Hypertension Arterielle (SFHTA)
FX This study was supported by a research grant from the Societe Francaise
   d'Hypertension Arterielle (SFHTA). C.L. reports grants, personal fees,
   and non-financial support from Lundbeck, personal fees from Servier,
   personal fees from Daiichi-Sankyo, non-financial support from Otsuka
   Pharmaceuticals, personal fees from Janssen, and outside the submitted
   work. The other authors report no conflicts of interest.
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NR 51
TC 6
Z9 7
U1 0
U2 8
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0033-3174
EI 1534-7796
J9 PSYCHOSOM MED
JI Psychosom. Med.
PD JUN
PY 2018
VL 80
IS 5
BP 460
EP 467
DI 10.1097/PSY.0000000000000592
PG 8
WC Psychiatry; Psychology; Psychology, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry; Psychology
GA GJ4BE
UT WOS:000435292000007
PM 29649036
DA 2025-06-11
ER

PT J
AU Couturier, K
   Hininger, I
   Poulet, L
   Anderson, RA
   Roussel, AM
   Canini, F
   Batandier, C
AF Couturier, Karine
   Hininger, Isabelle
   Poulet, Laurent
   Anderson, Richard A.
   Roussel, Anne-Marie
   Canini, Frederic
   Batandier, Cecile
TI Cinnamon intake alleviates the combined effects of dietary-induced
   insulin resistance and acute stress on brain mitochondria
SO JOURNAL OF NUTRITIONAL BIOCHEMISTRY
LA English
DT Article
DE Polyphenols; Brain; Mitochondria; Acute stress; Insulin resistance;
   Permeability transition pore
ID PERMEABILITY TRANSITION; RESPIRATORY-CHAIN; POLYPHENOLS; FAT;
   DYSFUNCTION; GLUCOSE; RATS; ROS; INHIBITION; METABOLISM
AB Insulin resistance (IR), which is a leading cause of the metabolic syndrome, results in early brain function alterations which may alter brain mitochondrial functioning. Previously, we demonstrated that rats fed a control diet and submitted to an acute restraint stress exhibited a delayed mitochondria] permeability transition pore (mPTP) opening. In this study, we evaluated the combined effects of dietary and emotional stressors as found in western way of life. We studied, in rats submitted or not to an acute stress, the effects of diet-induced IR on brain mitochondria, using a high fat/high fructose diet (HF2), as an IR inducer, with addition or not of cinnamon as an insulin sensitizer. We measured Ca2+ retention capacity, respiration, ROS production, enzymatic activities and cell signaling activation. Under stress, HF2 diet dramatically decreased the amount of Ca2+ required to open the mPTP (13%) suggesting an adverse effect on mitochondrial survival. Cinnamon added to the diet corrected this negative effect and resulted in a partial recovery (30%). The effects related to cinnamon addition to the diet could be due to its antioxidant properties or to the observed modulation of PI3K-AKT-GSK3 beta and MAPK-P38 pathways or to a combination of both. These data suggest a protective effect of cinnamon on brain mitochondria against the negative impact of an HF2 diet. Cinnamon could be beneficial to counteract deleterious dietary effects in stressed conditions. (C) 2015 Elsevier Inc. All rights reserved.
C1 [Couturier, Karine; Hininger, Isabelle; Poulet, Laurent; Roussel, Anne-Marie; Batandier, Cecile] Univ Grenoble Alpes, Lab Bioenerget Fondamentale & Appl, F-38041 Grenoble, France.
   [Couturier, Karine; Hininger, Isabelle; Poulet, Laurent; Roussel, Anne-Marie; Batandier, Cecile] INSERM, U1055, F-38041 Grenoble, France.
   [Anderson, Richard A.] USDA, Beltsville Human Nutr Res Ctr, Beltsville, MD 20705 USA.
   [Canini, Frederic] Inst Rech Biomed Armees IRBA, Dept Neurosci & Contraintes Operat, BP73, F-91223 Bretigny Sur Orge, France.
   [Canini, Frederic] Ecole Val Grace, 1 Pl Alphonse Laveran, F-75230 Paris, France.
   [Anderson, Richard A.] PolyChrom Technol, Edgewater, MD USA.
C3 Communaute Universite Grenoble Alpes; Universite Grenoble Alpes (UGA);
   Institut National de la Sante et de la Recherche Medicale (Inserm);
   United States Department of Agriculture (USDA)
RP Batandier, C (corresponding author), Univ Grenoble Alpes, Lab Bioenerget Fondamentale & Appl, INSERM, U1055, BP 53X, F-38041 Grenoble, France.
EM Cecile.Batandier@ujf-grenoble.fr
OI hininger-favier, isabelle/0000-0001-6726-7533; Poulet,
   Laurent/0000-0003-2795-4122
FU French National Agency for Research [PNRA 007]; ANR-Paris-France
   [ANR-07-PNRA-003-01]
FX This work is a part of the CERVIRMIT Study funded by the French National
   Agency for Research (PNRA 007): ANR-Paris-France (grant number
   ANR-07-PNRA-003-01).
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NR 47
TC 9
Z9 10
U1 0
U2 17
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0955-2863
EI 1873-4847
J9 J NUTR BIOCHEM
JI J. Nutr. Biochem.
PD FEB
PY 2016
VL 28
BP 183
EP 190
DI 10.1016/j.jnutbio.2015.10.016
PG 8
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA DF4YS
UT WOS:000371359100020
PM 26878796
DA 2025-06-11
ER

PT J
AU Jiang, YM
   Zhu, XY
   Jordan, K
   Li, YX
   Conley, S
   Tang, H
   Lerman, A
   Eirin, A
   Ou, TW
   Lerman, LO
AF Jiang, Yamei
   Zhu, Xiangyang
   Jordan, Kyra
   Li, Yongxin
   Conley, Sabena
   Tang, Hui
   Lerman, Amir
   Eirin, Alfonso
   Ou, Tongwen
   Lerman, Lilach O.
TI Dyslipidemia-induced renal fi brosis related to ferroptosis and
   endoplasmic reticulum stress
SO JOURNAL OF LIPID RESEARCH
LA English
DT Article
DE hypertriglyceridemia; hypercholesterolemia; ferroptosis; endoplasmic
   reticulum stress; renal fibrosis
ID METABOLIC SYNDROME; KIDNEY; INJURY; HYPERCHOLESTEROLEMIA; FIBROSIS
AB Dyslipidemia may induce chronic kidney disease and trigger both ferroptosis and endoplasmic reticulum (ER) stress, but the instigating factors are incompletely understood. We tested the hypothesis that different models of dyslipidemia engage distinct kidney injury mechanisms. Wild-type (WT) or proprotein-convertase subtilisin/kexin type-9 (PCSK9)-gain-of-function (GOF) Ossabaw pigs were fed with a 6-month normal diet (ND) or high-fat diet (HFD) (n = 5-6 each). Renal function and fat deposition were studied in vivo using CT, and blood and kidney tissue studied ex-vivo for lipid profile, systemic and renal vein FFAs levels, and renal injury mechanisms including lipid peroxidation, ferroptosis, and ER stress. Compared with WT-ND pigs, both HFD and PCSK9-GOF elevated triglyceride levels, which were highest in WT-HFD, whereas total and LDL cholesterol levels rose only in PCSK9-GOF pigs, particularly in PCSK9-GOF/HFD. The HFD groups had worse kidney function than the ND groups. The WT-HFD kidneys retained more FFA than other groups, but all kidneys developed fibrosis. Furthermore, HFD-induced ferroptosis in WT-HFD indicated by increased free iron, lipid peroxidation, and decreased glutathione peroxidase-4 mRNA expression, while PCSK9-GOF induced ER stress with upregulated GRP94 and CHOP protein expression. In vitro, pig kidney epithelial cells treated with palmitic acid and oxidized LDL to mimic HFD and PCSK9-GOF showed similar trends to those observed in vivo. Taken together, HFD-induced hypertriglyceridemia promotes renal FFA retention and ferroptosis, whereas PCSK9-GOF-induced hypercholesterolemia elicits ER stress, both resulting in renal fibrosis. These observations suggest different targets for preventing and treating renal fibrosis in subjects with specific types of dyslipidemia.
C1 [Jiang, Yamei; Zhu, Xiangyang; Jordan, Kyra; Li, Yongxin; Conley, Sabena; Tang, Hui; Eirin, Alfonso; Lerman, Lilach O.] Mayo Clin, Div Nephrol & Hypertens, Rochester, MN 55905 USA.
   [Jiang, Yamei; Ou, Tongwen] Capital Med Univ, Xuanwu Hosp, Dept Urol, Beijing, Peoples R China.
   [Lerman, Amir] Mayo Clin, Dept Cardiovasc Dis, Rochester, MN USA.
C3 Mayo Clinic; Capital Medical University; Mayo Clinic
RP Lerman, LO (corresponding author), Mayo Clin, Div Nephrol & Hypertens, Rochester, MN 55905 USA.
EM lerman.lilach@mayo.edu
RI Jiang, Yamei/GYR-0295-2022; Lerman, Lilach/M-4962-2017; Eirin,
   Alfonso/N-9873-2013; yang, xiao/JLL-7721-2023
OI Jiang, Yamei/0000-0002-7709-7328; Eirin, Alfonso/0000-0002-3864-9644
FU NIH [DK120292, DK122734, HL158691, AG062104]
FX This study was partly supported by Recombinetics and NIH grant numbers:
   DK120292, DK122734, HL158691, and AG062104. The content is solely the
   responsibility of the authors and does not necessarily represent the
   official views of the National Institutes of Health.
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NR 67
TC 8
Z9 8
U1 6
U2 11
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0022-2275
EI 1539-7262
J9 J LIPID RES
JI J. Lipid Res.
PD SEP
PY 2024
VL 65
IS 9
AR 100610
DI 10.1016/j.jlr.2024.100610
EA AUG 2024
PG 12
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA G5H6D
UT WOS:001316948000001
PM 39094771
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Li, ZY
   Wang, H
   Wu, KL
   Zhang, LF
AF Li, Zeyu
   Wang, Hong
   Wu, Kanglin
   Zhang, Lianfeng
TI Omarigliptin protects against nonalcoholic fatty liver disease by
   ameliorating oxidative stress and inflammation
SO JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
LA English
DT Article
DE diabetes; inflammation; NAFLD; omarigliptin; oxidative stress
ID INSULIN-RESISTANCE; ACUTE-PANCREATITIS; METABOLIC SYNDROME; LUNG INJURY;
   MANAGEMENT; PATHOGENESIS
AB Nonalcoholic fatty liver disease (NAFLD) is a prevalent liver disease with high morbidity. Omarigliptin is a novel antidiabetic drug that inhibits dipeptidyl peptidase-4 and alleviates inflammation and insulin resistance. In the present study, the anti-inflammatory and antioxidative stress property of omarigliptin will be investigated to explore the potential therapeutic effects of omarigliptin on NAFLD in mice models. A high-fat diet (HFD) was used to induce a NAFLD model in mice. Hematoxylin-eosin staining and detection on the concentrations of total cholesterol (TC) and triglyceride (TG) were used to evaluate lipid accumulation of the liver tissues. Liver function was evaluated by measuring aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, and lactate dehydrogenase. The insulin resistance index, the concentration of glucose, and insulin in the serum were determined. The levels of malondialdehyde and superoxide dismutase activities were detected to access the oxidative stress state. The concentrations of interleukin (IL)-1 alpha, IL-6, and CXCL1 were measured using an enzyme-linked immunosorbent assay. Western blot analysis was used to determine the expression levels of nuclear factor kappa B (NF-kappa B) p65 and SIRT1 in the liver tissues. Significant elevated body weight and liver weight, marked macrovesicular steatosis combined with hepatocellular ballooning on the liver tissues, accumulated TC and TG concentrations, damaged liver function, increased oxidative stress, and elevated production of inflammatory factors were all induced with an HFD and significantly reversed by treatment with omarigliptin. Also, the activated NF-kappa B signaling pathway, as well as suppressed SIRT1 expression level, were significantly reversed by omarigliptin. Omarigliptin protected against NAFLD by ameliorating oxidative stress and inflammation.
C1 [Li, Zeyu; Wang, Hong; Zhang, Lianfeng] Zhengzhou Univ, Dept Gastroenterol, Affiliated Hosp 1, 1,Jianshe E Rd, Zhengzhou 450000, Henan, Peoples R China.
   [Wu, Kanglin] Henan Univ Tradit Chinese Med, Dept Emergency, Affiliated Hosp 1, Zhengzhou, Henan, Peoples R China.
C3 Zhengzhou University; Henan University of Traditional Chinese Medicine
RP Zhang, LF (corresponding author), Zhengzhou Univ, Dept Gastroenterol, Affiliated Hosp 1, 1,Jianshe E Rd, Zhengzhou 450000, Henan, Peoples R China.
EM zhanglianfeng112@163.com
RI Li, Zeyu/GXM-4336-2022
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NR 33
TC 5
Z9 7
U1 0
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1095-6670
EI 1099-0461
J9 J BIOCHEM MOL TOXIC
JI J. Biochem. Mol. Toxicol.
PD DEC
PY 2021
VL 35
IS 12
AR e22914
DI 10.1002/jbt.22914
EA SEP 2021
PG 8
WC Biochemistry & Molecular Biology; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Toxicology
GA XO4FJ
UT WOS:000696486900001
PM 34533252
DA 2025-06-11
ER

PT J
AU Lundberg, U
   Hellström, B
AF Lundberg, U
   Hellström, B
TI Workload and morning salivary cortisol in women
SO WORK AND STRESS
LA English
DT Article
DE salivary cortisol; overtime; HPA axis; work-related stress
ID POSTTRAUMATIC-STRESS-DISORDER; WHITE-COLLAR WORKERS; BREAST-CANCER; JOB
   STRAIN; HEALTH; PAIN; MECHANISMS; DISEASE; SENSITIZATION; NEUROSCIENCE
AB Previous studies have shown a link between work-related stress and the morning level of the stress hormone cortisol. The level of cortisol in the circulation is regulated by the hypothalamic-pituitary-adrenocortical (HPA) axis, dysregulation of which plays an important role in a number of disorders including hypertension, immune deficiency and being overweight (the 'metabolic syndrome'). The aim of this study was to investigate the association between workload and morning cortisol in women. Saliva samples were obtained four times during the first 45 min after awakening (0, 15, 30 and 45 min) in the morning on a work-free day from more than 200 women in full-time work who were born in 195 and representing a normal population of a small city in Sweden. The amount of paid and unpaid work was reported in a questionnaire. Significant positive correlations were found between the amount of overtime at work and each of the four measurements of morning salivary cortisol (varying from r = .29 to r = .38 p < .01). In addition, participants with excessive overtime (more than 10h/week) had on average about twice as high (p < .01) morning cortisol levels as women with moderate overtime (<10 h/week) or normal working hours (35-40 h/week). The results are consistent with earlier findings and suggest that morning cortisol is a sensitive indicator of work overload in women. However, additional research is necessary in order to reveal the specific pathways linking work-related stress to elevated morning cortisol.
C1 Univ Stockholm, Dept Psychol, S-10691 Stockholm, Sweden.
   Univ Stockholm, CHESS, S-10691 Stockholm, Sweden.
C3 Stockholm University; Stockholm University
RP Univ Stockholm, Dept Psychol, S-10691 Stockholm, Sweden.
EM ul@psychology.su.se
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NR 41
TC 50
Z9 62
U1 0
U2 9
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0267-8373
EI 1464-5335
J9 WORK STRESS
JI Work Stress
PD OCT-DEC
PY 2002
VL 16
IS 4
BP 356
EP 363
DI 10.1080/0267837021000064427
PG 8
WC Psychology, Applied
WE Social Science Citation Index (SSCI)
SC Psychology
GA 659UQ
UT WOS:000181796200006
DA 2025-06-11
ER

PT J
AU Wang, Y
   Liu, BB
   Wu, PX
   Chu, Y
   Gui, SS
   Zheng, YZ
   Chen, XD
AF Wang, Yi
   Liu, Bingbing
   Wu, Peixuan
   Chu, Yi
   Gui, Sisi
   Zheng, Yazhen
   Chen, Xiaodong
TI Dietary Selenium Alleviated Mouse Liver Oxidative Stress and NAFLD
   Induced by Obesity by Regulating the KEAP1/NRF2 Pathway
SO ANTIOXIDANTS
LA English
DT Article
DE NAFLD (nonalcoholic fatty liver disease); dietary selenium; oxidative
   stress; KEAP1; NRF2 pathway
ID INSULIN-RESISTANCE; VITAMIN-E; DISEASE; SUPPLEMENTATION; ANGIOGENESIS;
   PATHOGENESIS; DEFICIENCY; METABOLISM; STIMULATOR; MODEL
AB Nonalcoholic fatty liver disease (NAFLD) occurs when excess fat is stored in the liver and it is strongly linked with metabolic syndrome and oxidative stress. Selenium (Se) is an essential micronutrient in animals, which has a variety of biological functions, including antioxidant and anti-inflammatory. However, the exact effect of dietary selenium on NAFLD and the underlying molecular mechanism are not yet clear. Herein, we fed a high-fat diet (HFD) to C57BL/6 mice to construct an in vivo NAFLD model, treated AML-12 cells with palmitic acid (PA) to construct an in vitro NAFLD model, and AML-12 cells were stimulated with H2O2 to induce hepatocyte oxidative stress and then treated with adequate selenium. We observed that adequate selenium significantly improved the hepatic injury and insulin resistance in HFD mice, and decreased the fat accumulation and the expression of lipogenic genes in PA-induced AML-12 cells. Meanwhile, selenium significantly inhibited the production of reactive oxygen species (ROS), inhibited apoptosis, and restored mitochondrial number and membrane potential in PA- induced AML-12 cells. In addition, selenium can promote selenoproteinP1 (SEPP1) synthesis to regulate the Kelch-like ECH-associated protein 1 (KEAP1)/NF-E2-related factor 2 (NRF2) pathway, so as to defend against hepatocyte oxidative stress. These findings suggest that dietary selenium supplementation can effectively resist hepatic injury and insulin resistance during NAFLD development, and regulate the KEAP1/NRF2 pathway to resist oxidative stress by promoting SEPP1 synthesis.
C1 [Wang, Yi; Liu, Bingbing; Chu, Yi; Gui, Sisi; Zheng, Yazhen; Chen, Xiaodong] Huazhong Agr Univ, Key Lab Agr Anim Genet Breeding & Reprod, Minist Educ, Coll Anim Sci & Technol, Wuhan 430070, Peoples R China.
   [Wang, Yi; Liu, Bingbing; Chu, Yi; Gui, Sisi; Zheng, Yazhen; Chen, Xiaodong] Huazhong Agr Univ, Coll Vet Med, Wuhan 430070, Peoples R China.
   [Wu, Peixuan] Huazhong Agr Univ, Coll Life Sci & Technol, Wuhan 430070, Peoples R China.
C3 Ministry of Education - China; Huazhong Agricultural University;
   Huazhong Agricultural University; Huazhong Agricultural University
RP Chen, XD (corresponding author), Huazhong Agr Univ, Key Lab Agr Anim Genet Breeding & Reprod, Minist Educ, Coll Anim Sci & Technol, Wuhan 430070, Peoples R China.; Chen, XD (corresponding author), Huazhong Agr Univ, Coll Vet Med, Wuhan 430070, Peoples R China.
EM wy@webmail.hzau.edu.cn; liubb@webmail.hzau.edu.cn;
   Wupeixuan@webmail.hzau.edu.cn; y313350648@webmail.hzau.edu.cn;
   gss.hzau.qq.com@webmail.hzau.edu.cn; zhengyzhen@webmail.hzau.edu.cn;
   chenxd@mail.hzau.edu.cn
OI Chen, Xiaodong/0000-0001-5717-849X
FU National Key Research and Development Program of China [2021YFF1000601,
   2018YFD0500401-03]; National Natural Science Foundation of China
   [31572382]
FX FundingThis research was funded by National Key Research and Development
   Program of China (No. 2021YFF1000601 and No. 2018YFD0500401-03) and
   National Natural Science Foundation of China (No. 31572382).
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NR 47
TC 63
Z9 65
U1 7
U2 84
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD FEB
PY 2022
VL 11
IS 2
AR 349
DI 10.3390/antiox11020349
PG 16
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA ZR2ZN
UT WOS:000767657900001
PM 35204232
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Nabuco, HCG
   Tomeleri, CM
   Fernandes, RR
   Sugihara Junior, P
   Venturini, D
   Barbosa, DS
   Deminice, R
   Sardinha, LB
   Cyrino, ES
AF Nabuco, Hellen C. G.
   Tomeleri, Crisieli M.
   Fernandes, Rodrigo R.
   Sugihara Junior, Paulo
   Venturini, Danielle
   Barbosa, Decio S.
   Deminice, Rafael
   Sardinha, Luis B.
   Cyrino, Edilson S.
TI Effects of pre- or post-exercise whey protein supplementation on
   oxidative stress and antioxidant enzymes in older women
SO SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
LA English
DT Article
DE aging; AOPP; catalase; protein timing; strength training
ID SERUM URIC-ACID; METABOLIC SYNDROME; EXERCISE; ASSOCIATION; IMPACT;
   DAMAGE; BLOOD
AB Background Oxidative stress is an imbalance between antioxidant system and production of free radicals and has been associated with the age-related deleterious changes. The defense system can be modulated by exercise and nutrition. Objective The purpose of this investigation was to evaluate the effect of whey protein supplementation pre- or post-resistance training on oxidative stress and antioxidant enzyme activity in pre-conditioned older women. Methods In a randomized, double-blind, and placebo-controlled design, 70 older women (>= 60 years) were randomly assigned to one of the following three groups: whey protein-placebo (WP-PLA, n = 24), placebo-whey protein (PLA-WP, n = 23), and placebo-placebo (PLA-PLA, n = 23). Each group received 35 g of whey product or placebo pre- and post-training. The RT program was carried out over 12 weeks (3x/week; 3x 8-12 repetitions maximal). Oxidative stress and blood markers were assessed before and after intervention period. ANOVA for repeated measures was used for data analysis. Results There was a significant time effect (P < 0.05), with all groups showing improvements in all oxidative stress markers and antioxidant enzyme activity. A significant (P < 0.001) interaction time vs group was observed for uric acid, with both WP-PLA and PLA-WP presenting greater reductions compared with the PLA-PLA, without differences between the timing of protein intake (WP-PLA: -8.3%; PLA-WP: -11.0%; PLA-PLA:-2.0%). Conclusion In already pre-conditioned older women, whey protein supplementation reduces plasma uric acid concentration with no further effect on antioxidant enzyme activity and oxidative stress markers. ClinicalTrials.gov: NCT03247192.
C1 [Nabuco, Hellen C. G.] Fed Inst Sci & Technol Mato Grosso, Highway BR-364,Km 329, BR-78106970 Cuiaba, MT, Brazil.
   [Nabuco, Hellen C. G.; Tomeleri, Crisieli M.; Fernandes, Rodrigo R.; Sugihara Junior, Paulo; Cyrino, Edilson S.] Univ Estadual Londrina, Phys Educ & Sport Ctr, Metab Nutr & Exercise Lab, Londrina, Brazil.
   [Tomeleri, Crisieli M.] Univ Campinas Unicamp, Fac Phys Educ, Exercise Physiol Lab, Campinas, Brazil.
   [Venturini, Danielle; Barbosa, Decio S.] Univ Estadual Londrina, Clin Anal Lab, Londrina, Brazil.
   [Deminice, Rafael; Cyrino, Edilson S.] Univ Estadual Londrina, Fac Phys Educ & Sport, Dept Phys Educ, Londrina, Brazil.
   [Sardinha, Luis B.] Univ Lisbon, Exercise & Hlth Lab, CIPER, Fac Motricidade Humana, Dafundo, Portugal.
C3 Universidade Estadual de Londrina; Universidade Estadual de Campinas;
   Universidade Estadual de Londrina; Universidade Estadual de Londrina;
   Universidade de Lisboa
RP Nabuco, HCG (corresponding author), Fed Inst Sci & Technol Mato Grosso, Highway BR-364,Km 329, BR-78106970 Cuiaba, MT, Brazil.
EM hellen.nabuco@svc.ifmt.edu.br
RI Deminice, Rafael/AAB-7871-2020; Venturini, Danielle/HPH-1330-2023;
   Barbosa, Décio/AAE-6351-2019; Sardinha, Luís/ABG-5389-2020; CYRINO,
   EDILSON/F-7196-2012
OI CYRINO, EDILSON/0000-0001-9016-8779; SUGIHARA JUNIOR,
   PAULO/0000-0002-9118-3492; Sardinha, Luis/0000-0002-6230-6027; Clair
   Garcez Nabuco, Hellen/0000-0001-9516-7812; Deminice,
   Rafael/0000-0002-9246-1079
FU Coordination for the Improvement of Higher Education Personnel
   (CAPES/Brazil); National Council for Scientific and Technological
   Development (CNPq/Brazil); Ministry of Education (MEC/Brazil)
FX This research was funded with budgetary resources from Coordination for
   the Improvement of Higher Education Personnel (CAPES/Brazil), the
   National Council for Scientific and Technological Development
   (CNPq/Brazil), and Ministry of Education (MEC/Brazil). And this study
   received supplements from Arla Foods Ingredients Group P/S (provide the
   samples of whey protein) and New Milen (provide the samples of
   maltodextrin)
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NR 40
TC 22
Z9 22
U1 0
U2 17
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0905-7188
EI 1600-0838
J9 SCAND J MED SCI SPOR
JI Scand. J. Med. Sci. Sports
PD AUG
PY 2019
VL 29
IS 8
BP 1101
EP 1108
DI 10.1111/sms.13449
PG 8
WC Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Sport Sciences
GA II8GV
UT WOS:000475431400004
PM 31050066
DA 2025-06-11
ER

PT J
AU Gu, M
   Zhao, P
   Zhang, SY
   Fan, SJ
   Yang, L
   Tong, QC
   Ji, G
   Huan, C
AF Gu, Ming
   Zhao, Ping
   Zhang, Shiying
   Fan, Shengjie
   Yang, Li
   Tong, Qingchun
   Ji, Guang
   Huan, Cheng
TI Betulinic acid alleviates endoplasmic reticulum stress-mediated
   nonalcoholic fatty liver disease through activation of farnesoid X
   receptors in mice
SO BRITISH JOURNAL OF PHARMACOLOGY
LA English
DT Article
ID CONCISE GUIDE; ER STRESS; NUCLEAR RECEPTOR; GLUCOSE-HOMEOSTASIS; HEPATIC
   STEATOSIS; STEATOHEPATITIS; SUPPRESSION; EXPRESSION; OBESITY;
   HYPERGLYCEMIA
AB Background and Purpose The molecular mechanism for the pathogenesis of nonalcoholic fatty liver disease (NAFLD) remains elusive. Both farnesoid X receptor (FXR) signalling and endoplasmic reticulum (ER) stress contribute to the progression of NAFLD; however, it is not clear whether the actions of these two pathways are dependent on each other. Moreover, the pharmacological benefits and mechanism of betulinic acid (BA) in controlling metabolic syndrome and NAFLD are largely unknown. Experimental Approach A reporter assay and a time-resolved FRET assay were used to identify BA as an agonist of the FXR. NAFLD was induced by a methionine and choline-deficient L-amino acid diet (MCD) and high-fat diet (HFD). The pharmacological effects of BA (100 mg center dot kg(-1)center dot day(-1)) and potential interactions between hepatic FXR activation and ER stress pathways were evaluated by FXR silencing, Western blot and RT-PCR analyses using control and FXR-/- mice. Key Results Activation of the FXR inhibited intracellular PERK/EIF2 alpha/ATF4 and CHOP signalling, thereby alleviating hepatic ER stress, whereas FXR silencing resulted in an opposite effect. Furthermore, we identified BA as an FXR agonist that effectively attenuated the progression of NAFLD and metabolic disorders in both HFD- and MCD diet-fed mice and restored the hepatocellular ER homeostasis by stimulating the FXR signalling pathway and blocking PERK/EIF2 alpha signalling. In contrast, the effects of BA were attenuated in FXR-/- mice. Conclusions and Implications Our data demonstrate that pharmacological activation of the FXR by BA reduces hepatocellular ER stress and attenuates NAFLD in an animal model of hepatic steatosis.
C1 [Gu, Ming; Ji, Guang] Shanghai Univ Tradit Chinese Med, Longhua Hosp, Inst Digest Dis, Shanghai 201203, Peoples R China.
   [Gu, Ming; Zhao, Ping; Zhang, Shiying; Fan, Shengjie; Huan, Cheng] Shanghai Univ Tradit Chinese Med, Sch Pharm, Shanghai 201203, Peoples R China.
   [Yang, Li] Shanghai Univ Tradit Chinese Med, Res Ctr Tradit Chinese Med Complex Syst, Shanghai, Peoples R China.
   [Tong, Qingchun] Univ Texas Houston, McGovern Med Sch, Grad Sch Biol Sci, Brown Fdn Inst Mol Med, Houston, TX USA.
   [Tong, Qingchun] Univ Texas Houston, McGovern Med Sch, Grad Sch Biol Sci, Program Neurosci, Houston, TX USA.
C3 Shanghai University of Traditional Chinese Medicine; Shanghai University
   of Traditional Chinese Medicine; Shanghai University of Traditional
   Chinese Medicine; University of Texas System; University of Texas Health
   Science Center Houston; University of Texas System; University of Texas
   Health Science Center Houston
RP Ji, G (corresponding author), Shanghai Univ Tradit Chinese Med, Longhua Hosp, Inst Digest Dis, Shanghai 201203, Peoples R China.; Huan, C (corresponding author), Shanghai Univ Tradit Chinese Med, Sch Pharm, Shanghai 201203, Peoples R China.
EM jiliver@vip.sina.com; chuang@shutcm.edu.cn
RI shiying, zhang/JJD-0690-2023
OI Huang, Cheng/0000-0003-0704-2943; Yang, Li/0000-0002-5484-0895; Tong,
   Qingchun/0000-0002-4561-2540
FU Natural Science Foundation of Shanghai [18ZR1440000]; National Natural
   Science Foundation of China [81620108030, 81803598]
FX Natural Science Foundation of Shanghai, Grant/Award Number: 18ZR1440000;
   National Natural Science Foundation of China, Grant/Award Numbers:
   81620108030 and 81803598
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NR 62
TC 51
Z9 56
U1 2
U2 55
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0007-1188
EI 1476-5381
J9 BRIT J PHARMACOL
JI Br. J. Pharmacol.
PD APR
PY 2019
VL 176
IS 7
BP 847
EP 863
DI 10.1111/bph.14570
PG 17
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA HQ3AZ
UT WOS:000462279900003
PM 30635917
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Gong, F
   Gu, JF
   Wang, HJ
AF Gong, Fen
   Gu, Junfei
   Wang, Haijun
TI Up regulated Tmbim1 activation promotes high fat diet (HFD)-induced
   cardiomyopathy by enhancement of inflammation and oxidative stress
SO BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
LA English
DT Article
DE Metabolic stress; Cardiomyopathy; Tmbim1; Inflammation; Oxidative stress
ID OBESITY CARDIOMYOPATHY; LIVER-DISEASE; CELL-DEATH; TNF-ALPHA;
   EXPRESSION; RECEPTORS; AUTOPHAGY; PROTECTS; RELEASE; FAMILY
AB The prevalence of cardiomyopathy due to metabolic stress has up-regulated dramatically; nevertheless, its molecular mechanisms remain unclear. Here we suggested that transmembrane BAX inhibitor motif containing 1 (Tmbim1) is down-regulated in the hearts of mice fed with high fat diet (HFD). We provided evidence that Tmbim1 knockout (KO) accelerated HFD-induced metabolic disorders in mice, as supported by the remarkable increase of fasting serum glucose and insulin levels. HFD-induced cardiac dysfunctions were greatly intensified by the loss of Trribim1, along with higher levels of lactate dehydrogenate (LDH) and creatine kinase (CK) in serum. In addition, Tmbim1 deletion significantly enhanced lipid accumulation in heart of mice administrated with HFD. Furthermore, Tmbim1 knockout reinforced myocardial inflammation, evidenced by increasing the expression of pro-inflammatory cytokines (interleukin 1 beta (IL-1 beta), IL-6 and tumor necrosis factor-alpha (TNF-alpha)), and the activation of nuclear factor-kappa B (NF-kappa B) signaling pathway. Tmbiml deficiency strengthened oxidative damage in hearts of HFD-fed mice, accompanied with a significant reduction of nuclear factor-erythroid 2 related factor 2 (Nrf-2) pathway. In palmitate (PA)-treated primary cardiomyocytes, Tmbim1 ablation markedly enhanced cell inflammation and oxidative stress, which were abolished by the suppression of ROS generation and NF-kappa B activation. Taken together, these findings suggested that Tmbim1 might be a key suppressor of metabolic stress-induced cardiomyopathy, which could be a promising target for the treatment of metabolic syndrome-triggered myocardial damage and heart failure. (C) 2018 Published by Elsevier Inc.
C1 [Gong, Fen] Jining 1 Peoples Hosp, Dept Surg Outpatient, Jining 272011, Peoples R China.
   [Gu, Junfei] Wannan Med Coll, Affiliated Hosp 2, Vasc Dis Res Ctr, Dept Endocrinol, Wuhu 241000, Peoples R China.
   [Wang, Haijun] Yanan Peoples Hosp, Dept Endocrinol, Yanan 716000, Peoples R China.
C3 Wannan Medical College
RP Wang, HJ (corresponding author), Yanan Peoples Hosp, Dept Endocrinol, Yanan 716000, Peoples R China.
EM 3444942754@qq.com
RI Wang, Haijun/O-1058-2018
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NR 35
TC 11
Z9 11
U1 0
U2 8
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0006-291X
EI 1090-2104
J9 BIOCHEM BIOPH RES CO
JI Biochem. Biophys. Res. Commun.
PD OCT 12
PY 2018
VL 504
IS 4
BP 797
EP 804
DI 10.1016/j.bbrc.2018.08.059
PG 8
WC Biochemistry & Molecular Biology; Biophysics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics
GA GX4EU
UT WOS:000447681200028
PM 30217448
DA 2025-06-11
ER

PT J
AU Czech, B
   Neumann, ID
   Müller, M
   Reber, SO
   Hellerbrand, C
AF Czech, Barbara
   Neumann, Inga D.
   Mueller, Martina
   Reber, Stefan O.
   Hellerbrand, Claus
TI Effect of chronic psychosocial stress on nonalcoholic steatohepatitis in
   mice
SO INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY
LA English
DT Article
DE Chronic psychosocial stress; nonalcoholic fatty liver disease (NAFLD);
   nonalcoholic steatohepatitis (NASH)
ID FATTY LIVER-DISEASE; HEPATIC STELLATE CELLS; METABOLIC SYNDROME;
   INSULIN-RESISTANCE; DIET; INFLAMMATION; RATS; FIBROSIS; FIBROGENESIS;
   MECHANISMS
AB Nonalcoholic fatty liver disease (NAFLD) is characterized by hepatic lipid accumulation which may progress towards inflammation (nonalcoholic steatohepatitis (NASH)). NAFLD is regarded as a consequence of a sedentary, food-abundant lifestyle which, in the modern world, often coincides with chronically high levels of perceived psychosocial stress. Here, we aimed to characterize the effect of chronic psychosocial stress on the development of NAFLD/NASH in male mice either fed with standard chow or NASH-inducing high fat diet. Chronic psychosocial stress was induced by chronic subordinate colony housing (CSC), a pre-clinically validated paradigm relevant for human affective and somatic disorders. Single housed (SHC) mice served as controls. Under standard chow conditions CSC mice revealed lower hepatic triglyceride levels but higher hepatic TNF alpha, MCP-1 and HMOX mRNA expression, while serum transaminase levels did not significantly differ from SHC mice. Under the NASH-inducing high-fat diet CSC and SHC mice showed similar body weight-gain and serum levels of glucose and adiponectin. Moreover, liver histology as well as TNF alpha, MCP-1 and HMOX expression were similar in CSC and SHC mice fed with HFD. Surprisingly, CSC showed even significantly lower transaminase levels than SHC mice fed with the same NASH-inducing diet. Together, these data indicate that under normal dietary conditions the CSC model induces noticeable hepatic oxidative stress and inflammation without causing manifest hepatocellular injury. In contrast, CSC exhibited a protective effect on hepatocellular injury in a dietary NASH-model. Identification of the underlying mechanisms of this phenomenon may lead to novel therapeutic strategies to prevent progression of NAFLD.
C1 [Czech, Barbara; Mueller, Martina; Hellerbrand, Claus] Univ Hosp Regensburg, Dept Internal Med 1, Regensburg, Germany.
   [Neumann, Inga D.; Reber, Stefan O.] Univ Regensburg, Inst Zool, Dept Behav & Mol Neurobiol, D-93042 Regensburg, Germany.
   [Reber, Stefan O.] Univ Ulm, Clin Psychosomat Med & Psychotherapy, Lab Mol Psychosomat, D-89069 Ulm, Germany.
C3 University of Regensburg; University of Regensburg; Ulm University
RP Hellerbrand, C (corresponding author), Univ Regensburg, Dept Internal Med 1, D-93042 Regensburg, Germany.
EM claus.hellerbrand@ukr.de
RI Martina, Mueller-Schilling/R-4162-2016
OI Muller-Schilling, Martina/0000-0002-8520-4568
FU German Research Association (DFG)
FX We are indebted to Heidi Gschwendtner, Monika Artinger, Dominik
   Langgartner and Nicole Grunwald for excellent technical assistance. This
   work was supported by grants from the German Research Association (DFG)
   to S.O.R. and C.H.
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NR 49
TC 31
Z9 32
U1 0
U2 8
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 1936-2625
J9 INT J CLIN EXP PATHO
JI Int. J. Clin. Exp. Pathol.
PY 2013
VL 6
IS 8
BP 1585
EP 1593
PG 9
WC Oncology; Pathology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Pathology
GA 216VX
UT WOS:000324315000014
PM 23923077
DA 2025-06-11
ER

PT J
AU Okyay, K
   Yilmaz, M
   Yildirir, A
   Eroglu, S
   Sade, E
   Sahinarslan, A
   Aydinalp, A
   Muderrisoglu, H
AF Okyay, K.
   Yilmaz, M.
   Yildirir, A.
   Eroglu, S.
   Sade, E.
   Sahinarslan, A.
   Aydinalp, A.
   Muderrisoglu, H.
TI Relationship between neutrophil-to-lymphocyte ratio and impaired
   myocardial perfusion in cardiac syndrome X
SO EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
LA English
DT Article
DE Cardiac syndrome X; Coronary microcirculation; Inflammation;
   Neutrophil-to-lymphocyte ratio
ID CORONARY-ARTERY-DISEASE; NEUTROPHIL/LYMPHOCYTE RATIO; ASSOCIATION;
   ANGIOGRAPHY; DYSFUNCTION; FLOW; PATHOPHYSIOLOGY; INFLAMMATION;
   MANAGEMENT; EXERCISE
AB OBJECTIVE: Myocardial tissue perfusion is decreased in patients with cardiac syndrome X (CSX). Systemic inflammation appears to be an important contributor to the diseased microvascular network of these patients. The neutrophil-to-lymphocyte ratio (NLR) is a surrogate marker of inflammation. Accordingly, we evaluated this biomarker concerning the microvascular circulation of CSX patients.
   PATIENTS AND METHODS: This study included 60 consecutive patients (54.1 +/- 7.8 years of age, 49 females) with CSX (typical chest pain, positive exercise stress test results, and normal coronary angiograms) and 60 consecutive age- and sex-matched control subjects. In all coronary territories, epicardial coronary flow was assessed by the Thrombolysis In Myocardial Infarction frame count (TFC) method, and myocardial tissue perfusion was assessed by the myocardial blush grade (MBG) method. Normal myocardial perfusion was accepted as an MBG score of 3 in all coronary territories.
   RESULTS: Patients with CSX had higher NLRs than those of control subjects (1.98 +/- 0.77 vs 1.72 +/- 0.55, respectively; p = 0.04). Among patients with CSX, those with impaired myocardial perfusion had higher NLRs than those with normal myocardial perfusion (2.13 +/- 0.82 vs 1.71 +/- 0.59, respectively; p = 0.028). There was a negative correlation between the NLR and total MBG score (p = 0.027, r = -0.29). Logistic regression analysis showed that the NLR was an independent and negative predictor of myocardial tissue perfusion (p = 0.027; Beta, -1.057; odds ratio, 2.878; 95% confidence interval, 1.129-7.335).
   CONCLUSIONS: Patients with CSX have high NLRs, and inflammation seems to be associated with distorted myocardial perfusion in these patients.
C1 [Okyay, K.; Yilmaz, M.; Yildirir, A.; Eroglu, S.; Sade, E.; Aydinalp, A.; Muderrisoglu, H.] Baskent Univ, Ankara Educ & Res Hosp, Sch Med, Dept Cardiol, TR-06490 Ankara, Turkey.
   [Sahinarslan, A.] Gazi Univ, Sch Med, Dept Cardiol, Ankara, Turkey.
C3 Ankara Training & Research Hospital; Baskent University; Gazi University
RP Okyay, K (corresponding author), Baskent Univ, Ankara Educ & Res Hosp, Sch Med, Dept Cardiol, Fevzi Cakmak Caddesi, TR-06490 Ankara, Turkey.
EM drokyay@yahoo.com
RI Aydınalp, Alp/AAD-5841-2021; Eroglu, Serpil/ABG-1582-2021; Sade, Leyla
   Elif/AAQ-7583-2021; YILDIRIR, Aylin/A-4947-2018; MUDERRISOGLU, IBRAHIM
   HALDUN/AAG-8233-2020; okyay, kaan/AAK-7355-2020
OI Eroglu, Serpil/0000-0003-3055-7953; Sade, Leyla
   Elif/0000-0003-3737-8595; YILDIRIR, Aylin/0000-0001-8750-5287;
   MUDERRISOGLU, IBRAHIM HALDUN/0000-0002-9635-6313; okyay,
   kaan/0000-0001-6134-8826
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NR 26
TC 14
Z9 15
U1 0
U2 7
PU VERDUCI PUBLISHER
PI ROME
PA VIA GREGORIO VII, ROME, 186-00165, ITALY
SN 1128-3602
J9 EUR REV MED PHARMACO
JI Eur. Rev. Med. Pharmacol. Sci.
PD MAY
PY 2015
VL 19
IS 10
BP 1881
EP 1887
PG 7
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA CJ9GW
UT WOS:000355811500023
PM 26044235
DA 2025-06-11
ER

PT J
AU Dalmády, S
   Kemény, L
   Antal, M
   Gyulai, R
AF Dalmady, Szandra
   Kemeny, Lajos
   Antal, Mark
   Gyulai, Rolland
TI Periodontitis: a newly identified comorbidity in psoriasis and psoriatic
   arthritis
SO EXPERT REVIEW OF CLINICAL IMMUNOLOGY
LA English
DT Review
DE Psoriasis; psoriatic arthritis; periodontitis; comorbidity; oral
   microbiota; smoking
ID GENOME-WIDE ASSOCIATION; PORPHYROMONAS-GINGIVALIS; RHEUMATOID-ARTHRITIS;
   SUSCEPTIBILITY LOCI; CUTANEOUS PSORIASIS; GENE POLYMORPHISMS;
   RISK-FACTORS; HLA DR4; DISEASE; IMMUNOPATHOGENESIS
AB Introduction: Psoriasis is a chronic autoimmune skin disease with strong genetic background and environmental triggers. Patients with psoriasis and psoriatic arthritis are at greater risk of developing other chronic and potentially severe comorbidities, such as psoriatic arthritis, hyperlipidemia, type 2 diabetes mellitus, obesity, metabolic syndrome, cardiovascular diseases or depression. Recently, accumulating epidemiologic, genetic and pathogenetic evidence indicates that psoriasis is also associated with periodontitis, a chronic progressive inflammatory disease, which may result in tooth loss without early and adequate therapy. Areas covered: In this review article we summarize and discuss in detail the available epidemiologic, genetic, microbiological and immunological links between psoriasis and periodontitis. Expert opinion: Periodontitis, via the immunomodulatory effect of the oral microbiota, may play both a direct and indirect role in the development or exacerbation of psoriasis, and may influence the efficacy of antipsoriatic therapy. These new findings indicate a need for increased awareness, early recognition and focus on prevention of periodontitis for patients with psoriasis.
C1 [Dalmady, Szandra; Kemeny, Lajos] Univ Szeged, Dept Dermatol & Allergol, Koranyi St, H-6720 Szeged, Hungary.
   [Kemeny, Lajos] Univ Szeged, MTA SZTE Dermatol Res Grp, Szeged, Hungary.
   [Kemeny, Lajos] Univ Szeged, HCEMM SZTE Skin Res Grp, Szeged, Hungary.
   [Antal, Mark] Univ Szeged, Dept Operat & Esthet Dent, Szeged, Hungary.
   [Gyulai, Rolland] Univ Pecs, Fac Med, Dept Dermatol Venerol & Oncodermatol, Pecs, Hungary.
C3 Szeged University; HUN-REN; Office for Supported Research Groups (ELKH);
   Szeged University; Szeged University; Szeged University; University of
   Pecs
RP Dalmády, S (corresponding author), Univ Szeged, Dept Dermatol & Allergol, Koranyi St, H-6720 Szeged, Hungary.
EM dalmady.szandra@med.u-szeged.hu
RI Antal, Mark/AAJ-5947-2021; Antal, Mark/AAB-3996-2022; Gyulai,
   Rolland/AAE-2765-2020
OI Antal, Mark/0000-0002-4109-9356; Gyulai, Rolland/0000-0002-3286-8846;
   Dalmady, Szandra Kata/0000-0001-7362-5640
FU [GINOP-2.3.2-15-2016-00015];  [GINOP-2.3.2-15-2016-00050];  [OTKA
   K-18-128210]
FX This work was performed with the financial support of
   GINOP-2.3.2-15-2016-00015 (LK), GINOP-2.3.2-15-2016-00050 (RG), and OTKA
   K-18-128210 (RG).
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NR 90
TC 32
Z9 34
U1 1
U2 10
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1744-666X
EI 1744-8409
J9 EXPERT REV CLIN IMMU
JI Expert Rev. Clin. Immunol.
PD JAN 2
PY 2020
VL 16
IS 1
BP 101
EP 108
DI 10.1080/1744666X.2019.1700113
EA DEC 2019
PG 8
WC Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology
GA KD7UN
UT WOS:000502184000001
PM 31825680
DA 2025-06-11
ER

PT J
AU Knechtle, B
   Economou, NT
   Nikolaidis, PT
   Velentza, L
   Kallianos, A
   Steiropoulos, P
   Koutsompolis, D
   Rosemann, T
   Trakada, G
AF Knechtle, Beat
   Economou, Nicholas-Tiberio
   Nikolaidis, Pantelis T.
   Velentza, Lemonia
   Kallianos, Anastasios
   Steiropoulos, Paschalis
   Koutsompolis, Dimitrios
   Rosemann, Thomas
   Trakada, Georgia
TI Clinical Characteristics of Obstructive Sleep Apnea in Psychiatric
   Disease
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Article
DE obstructive sleep apnea; psychiatric disease; major depressive disorder;
   bipolar disorder; schizophrenia and psychotic disorder; sleep study
ID METABOLIC SYNDROME; LUNG-FUNCTION; OBESITY; PREVALENCE; DEPRESSION;
   DISORDERS; PRESSURE; SCHIZOPHRENIA; ASSOCIATION; POPULATION
AB Patients with serious psychiatric diseases (major depressive disorder (MDD), bipolar disorder (BD), and schizophrenia and psychotic disorder) often complain about sleepiness during the day, fatigue, low energy, concentration problems, and insomnia; unfortunately, many of these symptoms are also frequent in patients with Obstructive Sleep Apnea (OSA). However, existing data about the clinical appearance of OSA in Psychiatric Disease are generally missing. The aim of our study was a detailed and focused evaluation of OSA in Psychiatric Disease, in terms of symptoms, comorbidities, clinical characteristics, daytime respiratory function, and overnight polysomnography data. We examined 110 patients (56 males and 54 females) with stable Psychiatric Disease (Group A: 66 with MDD, Group B: 34 with BD, and Group C: 10 with schizophrenia). At baseline, each patient answered the STOP-Bang Questionnaire, Epworth Sleepiness Scale (ESS), Fatigue Severity Scale (FSS), and Hospital Anxiety and Depression Scale (HADS) and underwent clinical examination, oximetry, spirometry, and overnight polysomnography. Body Mass Index (BMI), neck, waist, and hip circumferences, and arterial blood pressure values were also measured. The mean age of the whole population was 55.1 +/- 10.6 years. The three groups had no statistically significant difference in age, BMI, hip circumference, and systolic and diastolic arterial blood pressure. Class II and III obesity with BMI > 35 kg/m(2) was observed in 36 subjects (32.14%). A moderate main effect of psychiatric disease was observed in neck (p = 0.044, (2) = 0.064) and waist circumference (p = 0.021, (2) = 0.078), with the depression group showing the lowest values, and in pulmonary function (Forced Vital Capacity (FVC, %), p = 0.013, (2) = 0.084), with the psychotic group showing the lowest values. Intermediate to high risk of OSA was present in 87.37% of participants, according to the STOP-Bang Questionnaire (3 positive answers), and 70.87% responded positively for feeling tired or sleepy during the day. An Apnea-Hypopnea Index (AHI) 15 events per hour of sleep was recorded in 72.48% of our patients. AHI was associated positively with male sex, schizophrenia, neck, and waist circumferences, STOP-Bang and ESS scores, and negatively with respiratory function. A large main effect of psychiatric medications was observed in waist circumference (p = 0.046, (2) = 0.151), FVC (%) (p = 0.027, (2) = 0.165), and in time spend with SaO(2) < 90% (p = 0.006, (2) = 0.211). Our study yielded that patients with Psychiatric Disease are at risk of OSA, especially men suffering from schizophrenia and psychotic disorders that complain about sleepiness and have central obesity and disturbed respiratory function. Screening for OSA is mandatory in this medical population, as psychiatric patients have significantly poorer physical health than the general population and the coexistence of the two diseases can further negatively impact several health outcomes.
C1 [Knechtle, Beat; Rosemann, Thomas] Univ Zurich, Inst Primary Care, CH-8091 Zurich, Switzerland.
   [Economou, Nicholas-Tiberio; Velentza, Lemonia; Kallianos, Anastasios; Koutsompolis, Dimitrios; Trakada, Georgia] Univ Athens, Alexandra Hosp, Sch Med, Div Pulmonol,Dept Clin Therapeut, Athens 11528, Greece.
   [Nikolaidis, Pantelis T.] Exercise Physiol Lab, Nikaia 18450, Greece.
   [Steiropoulos, Paschalis] Democritus Univ Thrace, Univ Hosp Alexandroupolis, Med Sch, Dept Pulmonol, Alexandroupolis 68100, Greece.
C3 University of Zurich; National & Kapodistrian University of Athens;
   Alexandra Hospital; Athens Medical School; Democritus University of
   Thrace
RP Trakada, G (corresponding author), Univ Athens, Alexandra Hosp, Sch Med, Div Pulmonol,Dept Clin Therapeut, Athens 11528, Greece.
EM beat.knechtle@hispeed.ch; nt_economou@yahoo.it; pademil@hotmail.com;
   lemvele@gmail.com; kallianos.pulm@gmail.com; steiropoulos@yahoo.com;
   dkg348483@gmail.com; thomas.rosemann@usz.ch; gtrakada@hotmail.com
RI Knechtle, Beat/ABC-5529-2020; Steiropoulos, Paschalis/AAH-6905-2021;
   Trakada, Georgia/S-3844-2019; Nikolaidis, Pantelis/K-8664-2017
OI Nikolaidis, Pantelis/0000-0001-8030-7122; Trakada,
   Georgia/0000-0003-0037-1269; Rosemann, Thomas/0000-0002-6436-6306;
   Knechtle, Beat/0000-0002-2412-9103
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NR 38
TC 22
Z9 23
U1 0
U2 6
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD APR
PY 2019
VL 8
IS 4
AR 534
DI 10.3390/jcm8040534
PG 12
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA HX6FT
UT WOS:000467500200119
PM 31003451
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Estrada-Cruz, NA
   Manuel-Apolinar, L
   Segura-Uribe, JJ
   Almanza-Pérez, JC
   Fortis-Barrera, A
   Orozco-Suárez, S
   Bautista-Poblet, G
   Coyoy-Salgado, A
   Guerra-Araiza, C
AF Estrada-Cruz, Norma A.
   Manuel-Apolinar, Leticia
   Segura-Uribe, Julia J.
   Almanza-Perez, Julio C.
   Fortis-Barrera, Angeles
   Orozco-Suarez, Sandra
   Bautista-Poblet, Guadalupe
   Coyoy-Salgado, Angelica
   Guerra-Araiza, Christian
TI Short-term administration of tibolone reduces inflammation and oxidative
   stress in the hippocampus of ovariectomized rats fed high-fat and
   high-fructose
SO NUTRITIONAL NEUROSCIENCE
LA English
DT Article
DE Overnutrition; hippocampus; high-fat-and-high-fructose diet; oxidative
   stress; inflammation; estrogenic decline; hormone receptors; hormone
   receptor antagonists
ID HORMONE-REPLACEMENT THERAPY; ESTROGEN-RECEPTOR; METABOLIC SYNDROME;
   END-PRODUCTS; CHOLESTEROL; BRAIN; DISEASE; GLUTATHIONE; BETA;
   INTERLEUKIN-6
AB Inflammation and oxidative stress are critical events involved in neurodegeneration. In animal models, it has been shown that chronic consumption of a hypercaloric diet, which leads to inflammatory processes, affects the hippocampus, a brain region fundamental for learning and memory processes. In addition, advanced age and menopause are risk factors for neurodegeneration. Hormone replacement therapy (HRT) ameliorates menopause symptoms. Tibolone (TB), a synthetic hormone, exerts estrogenic, progestogenic and androgenic effects on different tissues. We aimed to determine the effect of short-term TB administration on oxidative stress and inflammation markers in the hippocampus of ovariectomized rats fed a high-fat-and-fructose diet (HFFD). Adult female rats were ovariectomized (OVX) and fed standard diet or HFFD-consisting of 10% lard supplemented chow and 20% high-fructose syrup in the drinking water-and administered vehicle or TB (1 mg/kg for seven days). Finally, we administered hormone receptor antagonists (MPP, RU486 or FLU) to each of the OVX + HFFD + TB groups. Bodyweight, triglycerides and cholesterol, oxidative stress and inflammation markers, and the activity and expression of antioxidant enzymes were quantified in the hippocampus of each experimental group. We observed that short-term TB administration significantly reduced body weight, AGEs, MDA levels, increased SOD and GPx activity, improved GSH/GSSG ratio, and reduced IL-6 and TNF-alpha. Our findings suggest that short-term administration of TB decreases oxidative stress and reduces inflammation caused by HFFD and early estrogenic decline. These effects occurred via estrogen receptor alpha.
C1 [Estrada-Cruz, Norma A.; Bautista-Poblet, Guadalupe; Guerra-Araiza, Christian] Inst Mexicano Seguro Social IMSS, Ctr Med Nacl CMN Siglo 21, Unidad Invest Med Farmacol, Mexico City, DF, Mexico.
   [Manuel-Apolinar, Leticia] IMSS, CMN Siglo 21, Unidad Invest Med Enfermedades Endocrinas, Mexico City, DF, Mexico.
   [Segura-Uribe, Julia J.] Hosp Infantil Mexico Dr Federico Gomez, Subdirecc Gest Invest, Mexico City, DF, Mexico.
   [Almanza-Perez, Julio C.; Fortis-Barrera, Angeles] UAM 1, Lab Farmacol, Dept Ciencias Salud, Mexico City, DF, Mexico.
   [Orozco-Suarez, Sandra] IMSS, CMN Siglo 21, Unidad Invest Med Enfermedades Neurol, Mexico City, DF, Mexico.
   [Coyoy-Salgado, Angelica] IMSS, Catedras CONACyT Unidad Invest Med Enfermedades N, Mexico City, DF, Mexico.
C3 Instituto Mexicano del Seguro Social; Instituto Mexicano del Seguro
   Social; Hospital Infantil de Mexico Federico Gomez; Universidad Autonoma
   Metropolitana - Mexico; Instituto Mexicano del Seguro Social; Instituto
   Mexicano del Seguro Social
RP Guerra-Araiza, C (corresponding author), Inst Mexicano Seguro Social IMSS, Ctr Med Nacl CMN Siglo 21, Unidad Invest Med Farmacol, Mexico City, DF, Mexico.
EM christianguerra2001@gmail.com
RI Manuel, Leticia/ABC-7215-2020; Segura-Uribe, Julia/AAD-7192-2020; Coyoy,
   Angelica/GZG-5070-2022
OI Fortis-Barrera, Angeles/0000-0003-0923-501X; Coyoy,
   Angelica/0000-0001-7007-9509; Bautista-Poblet,
   Guadalupe/0000-0001-7233-186X; Manuel-Apolinar,
   Leticia/0000-0001-8175-4215; Orozco-Suarez, Sandra/0000-0001-5289-8500
FU Instituto Mexicano del Seguro Social [R-2018-785-016]
FX This work was supported by the Instituto Mexicano del Seguro Social
   [grant number R-2018-785-016].
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NR 69
TC 9
Z9 10
U1 1
U2 6
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1028-415X
EI 1476-8305
J9 NUTR NEUROSCI
JI Nutr. Neurosci.
PD APR 3
PY 2023
VL 26
IS 4
BP 275
EP 289
DI 10.1080/1028415X.2022.2046964
EA MAR 2022
PG 15
WC Neurosciences; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Nutrition & Dietetics
GA 9E5NQ
UT WOS:000768047300001
PM 35282801
DA 2025-06-11
ER

PT J
AU Yin, JT
AF Yin, Jintang
TI Mitigation of Insulin Resistance, Inflammation, Oxidative Stress, and
   Metabolic Abnormalities by Bavachalcone in High-Fat/High-Fructose
   Diet-Fed Rats
SO INDIAN JOURNAL OF PHARMACEUTICAL EDUCATION AND RESEARCH
LA English
DT Article
DE Metabolic syndrome; Fatty liver; Bavachalcone; Insulin resistance;
   Inflammation.
ID OBESITY
AB Background: Obesity is defined by an excess of body fat, together with insulin resistance and dyslipidemia. These factors significantly elevate the risk of acquiring chronic disorders such as goal of the current study was to evaluate bavachalcone's beneficial effects on insulin resistance and obesity in experimental rats fed a High-Fat and High-Fructose (HFa-HFr) diet. Materials and Methods: The metabolic complications were induced in rats by HFa-HFr diet feeding for a period of 10 weeks and treated with bavachalcone from the 5th to the 10th weeks. The effects of bavachalcone on various parameters such as food and water consumption, body weight, insulin, blood glucose level, serum biochemical markers, liver oxidative stress markers, and proinflammatory cytokine levels were assessed after treatment. Additionally, a histopathological examination was conducted on the liver tissues. Results: The findings showed that the rats fed with the HFa-HFr diet exhibited a notable elevation in blood glucose, insulin level, body weight, fat deposits, and liver marker enzyme activities. These changes were effectively mitigated by the bavachalcone treatment. Furthermore, the HFa-HFr diet resulted in elevated fat accumulation, oxidative stress, and inflammatory biomarker levels. In contrast, bavachalcone treatment successfully reduced insulin resistance, fat deposition, inflammatory, and oxidative stress conditions in the HFa-HFr diet-fed rats. Conclusion: The results clearly showed that bavachalcone treatment successfully mitigated the HFa-HFr diet-caused metabolic abnormalities by reducing fat deposition and inflammatory and oxidative stress markers.
C1 [Yin, Jintang] Lanzhou Mental Hlth Ctr, Dept Clin Lab, Lanzhou 730010, Gansu, Peoples R China.
RP Yin, JT (corresponding author), Lanzhou Mental Hlth Ctr, Dept Clin Lab, Lanzhou 730010, Gansu, Peoples R China.
EM xinlang1232qq@sina.com
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NR 37
TC 0
Z9 0
U1 0
U2 0
PU ASSOC PHARMACEUTICAL TEACHERS INDIA
PI BANGALORE
PA AL-AMEEN COLL PHARMACY, OPP LALBACH MAIN GATE, HOSUR MAIN RD, BANGALORE,
   560 027, INDIA
SN 0019-5464
J9 INDIAN J PHARM EDUC
JI Indian J. Pharm. Educ. Res.
PD JAN-MAR
PY 2025
VL 59
IS 1
BP 134
EP 143
DI 10.5530/ijper.20257230
PG 10
WC Education, Scientific Disciplines; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Education & Educational Research; Pharmacology & Pharmacy
GA R4V6T
UT WOS:001391449800014
DA 2025-06-11
ER

PT J
AU Kim, B
   Kim, MS
   Hyun, CK
AF Kim, Bobae
   Kim, Min-Seok
   Hyun, Chang -Kee
TI Syringin attenuates insulin resistance via adiponectin-mediated
   suppression of low-grade chronic inflammation and ER stress in high-fat
   diet-fed mice
SO BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
LA English
DT Article
DE Syringin (PubChem CID: 5316860); Insulin resistance; Adiponectin;
   Chronic inflammation; AMPK; ER stress
ID ENDOPLASMIC-RETICULUM STRESS; ACTIVATED PROTEIN-KINASE; SKELETAL-MUSCLE;
   ELEUTHEROCOCCUS-SENTICOSUS; METABOLIC SYNDROME; WISTAR RATS; EXPRESSION;
   AMPK; SENSITIVITY; MECHANISM
AB In the treatment of type 2 diabetes, improvements in glucose control are often linked to side effects such as weight gain and altered lipid metabolism, increasing the risk of cardiovascular disease. It is therefore important to develop antidiabetic drugs that exert beneficial effects on insulin sensitivity and lipid metabolism at the same time. Here we demonstrate that syringin, a naturally occurring glucoside, improves glucose tolerance without increased weight gain in high-fat diet-induced obese mice. Syringin augmented insulin-stimulated Akt phosphorylation in skeletal muscle, epididymal adipose tissue (EAT), and the liver, showing an insulin-sensitizing activity. Syringin-treated mice also showed markedly elevated adiponectin production in EAT and suppressed expression of pro-inflammatory cytokines in peripheral tissues, indicating a significant reduction in low-grade chronic inflammation. Additionally, syringin enhanced AMP-activated protein kinase activity and decreased the expression of lipogenic genes in skeletal muscle, which was associated with reduced endoplasmic reticulum (ER) stress. Taken together, our data suggest that syringin attenuates HFD-induced insulin resistance through the suppressive effect of adiponectin on low-grade inflammation, lipotoxicity, and ER stress, and show syringin as a potential therapeutic agent for prevention and treatment of type 2 diabetes with low risk of adverse effects such as weight gain and dysregulated lipid metabolism. (C) 2017 Elsevier Inc. All rights reserved.
C1 [Kim, Bobae; Kim, Min-Seok; Hyun, Chang -Kee] Handong Global Univ, Sch Life Sci, Pohang 37554, Gyungbuk, South Korea.
C3 Handong Global University
RP Hyun, CK (corresponding author), Handong Global Univ, Sch Life Sci, Pohang 37554, Gyungbuk, South Korea.
EM ckhyun@handong.edu
RI Kim, Minseok/AAJ-3052-2020
FU Basic Science Research Program through the National Research Foundation
   of Korea - Ministry of Education [NRF-2015R1D1A1A01058699]
FX This research was supported by Basic Science Research Program through
   the National Research Foundation of Korea funded by the Ministry of
   Education (NRF-2015R1D1A1A01058699).
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NR 27
TC 36
Z9 37
U1 0
U2 21
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0006-291X
EI 1090-2104
J9 BIOCHEM BIOPH RES CO
JI Biochem. Biophys. Res. Commun.
PD JUN 17
PY 2017
VL 488
IS 1
BP 40
EP 45
DI 10.1016/j.bbrc.2017.05.003
PG 6
WC Biochemistry & Molecular Biology; Biophysics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics
GA EW6AG
UT WOS:000402587000007
PM 28476623
DA 2025-06-11
ER

PT J
AU Xu, JQ
   Liu, XL
   Gao, H
   Chen, C
   Deng, QC
   Huang, QD
   Ma, ZH
   Huang, FH
AF Xu, Jiqu
   Liu, Xiaoli
   Gao, Hui
   Chen, Chang
   Deng, Qianchun
   Huang, Qingde
   Ma, Zhonghua
   Huang, Fenghong
TI Optimized Rapeseed Oils Rich in Endogenous Micronutrients Protect High
   Fat Diet Fed Rats from Hepatic Lipid Accumulation and Oxidative Stress
SO NUTRIENTS
LA English
DT Article
DE optimized rapeseed oils; micronutrients; lipid accumulation; oxidant
   stress; nonalcoholic fatty liver disease
ID ACTIVATED RECEPTOR-ALPHA; BETA-SITOSTEROL; METABOLIC SYNDROME;
   GENE-REGULATION; PHENOLIC-ACIDS; LIVER-DISEASE; POLYPHENOL; MICE;
   CHOLESTEROL; GLUTATHIONE
AB Micronutrients in rapeseed exert a potential benefit to hepatoprotection, but most of them are lost during the conventional refining processing. Thus some processing technologies have been optimized to improve micronutrient retention in oil. The aim of this study is to assess whether optimized rapeseed oils (OROs) have positive effects on hepatic lipid accumulation and oxidative stress induced by a high-fat diet. Methods: Rats received experiment diets containing 20% fat and refined rapeseed oil or OROs obtained with various processing technologies as lipid source. After 10 weeks of treatment, liver was assayed for lipid accumulation and oxidative stress. Results: All OROs reduced hepatic triglyceride contents. Microwave pretreatment-cold pressing oil (MPCPO) which had the highest micronutrients contents also reduced hepatic cholesterol level. MPCPO significantly decreased hepatic sterol regulatory element-binding transcription factor 1 (SREBP1) but increased peroxisome proliferator activated receptor (PPAR) expressions, and as a result, MPCPO significantly suppressed acetyl CoA carboxylase and induced carnitine palmitoyl transferase-1 and acyl CoA oxidase expression. Hepatic catalase (CAT) and glutathione peroxidase (GPx) activities as well as reduced glutathione (GSH) contents remarkably increased and lipid peroxidation levels decreased in parallel with the increase of micronutrients. Conclusion: OROs had the ability to reduce excessive hepatic fat accumulation and oxidative stress, which indicated that OROs might contribute to ameliorating nonalcoholic fatty liver induced by high-fat diet.
C1 [Xu, Jiqu; Liu, Xiaoli; Deng, Qianchun; Huang, Qingde; Huang, Fenghong] Chinese Acad Agr Sci, Oil Crops Res Inst, Dept Prod Proc & Nutriol, Wuhan 430062, Peoples R China.
   [Xu, Jiqu; Liu, Xiaoli; Deng, Qianchun; Huang, Qingde; Huang, Fenghong] Chinese Acad Agr Sci, Oil Crops Res Inst, Hubei Key Lab Lipid Chem & Nutr, Wuhan 430062, Peoples R China.
   [Gao, Hui] Huazhong Univ Sci & Technol, Sch Publ Hlth, Dept Nutr & Food Hyg, Tongji Med Coll, Wuhan 430030, Peoples R China.
   [Chen, Chang] China Three Gorges Univ, Peoples Hosp, Dept Gastroenterol, Peoples Hosp Yichang 1, Yichang 443000, Peoples R China.
   [Chen, Chang] China Three Gorges Univ, Dept Gastroenterol, Peoples Hosp, Yichang 443000, Peoples R China.
   [Ma, Zhonghua] Chinese Acad Agr Sci & Infinite China Co LTD, Funct Oil Lab Associated Oil Crops Res Inst, Guangzhou 510665, Guangdong, Peoples R China.
C3 Chinese Academy of Agricultural Sciences; Oil Crops Research Institute,
   CAAS; Chinese Academy of Agricultural Sciences; Oil Crops Research
   Institute, CAAS; Huazhong University of Science & Technology; China
   Three Gorges University; China Three Gorges University; Chinese Academy
   of Agricultural Sciences; Oil Crops Research Institute, CAAS
RP Huang, FH (corresponding author), Chinese Acad Agr Sci, Oil Crops Res Inst, Dept Prod Proc & Nutriol, 2 Xudong Second Rd, Wuhan 430062, Peoples R China.
EM xujiqu@foxmail.com; liuxiaoli_ocri@sina.com; gaohuitj@yeah.net;
   chenchang1976@163.com; qianch2@foxmail.com; viperson1973@foxmail.com;
   zhhuama@163.com; fhhuang@foxmail.com
FU National Natural Science Foundation of China [NSFC-31271856]; earmarked
   fund for Modern Agro-industry Technology Research System, China
FX This work was supported by National Natural Science Foundation of China
   (NSFC-31271856) and the earmarked fund for Modern Agro-industry
   Technology Research System, China.
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NR 52
TC 9
Z9 11
U1 0
U2 20
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD OCT
PY 2015
VL 7
IS 10
BP 8491
EP 8502
DI 10.3390/nu7105407
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA CV4IZ
UT WOS:000364231700019
PM 26473919
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Martinelli, N
   García-Heredia, A
   Roca, H
   Aranda, N
   Arija, V
   Mackness, B
   Mackness, M
   Busti, F
   Aragonès, G
   Pedro-Botet, J
   Pedica, F
   Cataldo, I
   Marsillach, J
   Joven, J
   Girelli, D
   Camps, J
AF Martinelli, Nicola
   Garcia-Heredia, Anabel
   Roca, Helena
   Aranda, Nuria
   Arija, Victoria
   Mackness, Bharti
   Mackness, Michael
   Busti, Fabiana
   Aragones, Gerard
   Pedro-Botet, Juan
   Pedica, Federica
   Cataldo, Ivana
   Marsillach, Judit
   Joven, Jorge
   Girelli, Domenico
   Camps, Jordi
TI Paraoxonase-1 status in patients with hereditary hemochromatosis
SO JOURNAL OF LIPID RESEARCH
LA English
DT Article
DE antioxidants; inflammation; iron metabolism; oxidative stress
ID MONOCYTE CHEMOATTRACTANT PROTEIN-1; CHRONIC LIVER IMPAIRMENT;
   HIGH-DENSITY-LIPOPROTEIN; CORONARY-ARTERY-DISEASE; SERUM-AMYLOID-A;
   METABOLIC SYNDROME; HFE-HEMOCHROMATOSIS; OXIDATIVE STRESS;
   IRON-OVERLOAD; EXPRESSION
AB Hereditary hemochromatosis (HH) is characterized by accumulation of iron, oxidative stress, inflammation, and fibrogenesis in liver tissue. In this setting, research on the protection afforded by intracellular antioxidants is of clinical relevance. Paraoxonase-1 (PON1) is an enzyme that degrades lipid peroxides. This study investigates the alterations in serum PON1 status, PON1 gene polymorphisms, and PON1 hepatic expression in patients with HH. We performed a case-control study in 77 patients with HH (80.5% men, 22-70 years of age) and 408 healthy individuals (43.1% men, 26-74 years of age). Serum PON1 activities against different substrates and PON1 192 and PON1 55 polymorphisms were analyzed. PON1 protein expression was investigated in 20 liver biopsies. HH patients had significantly lower serum PON1 activity, which was inversely correlated with ferritin (marker of iron stores) and serum 8-isoprostane concentrations (index of oxidative stress). PON1 protein expression in liver tissue was higher in patients and showed stronger staining in hepatocytes surrounding the areas of inflammation. Our study provides preliminary evidence that PON1 may play a role in protecting against iron-induced oxidative stress in hereditary hemochromatosis.-Martinelli, N., A. Garcia-Heredia, H. Roca, N. Aranda, V. Arija, B. Mackness, M. Mackness, F. Busti, G. Aragones, J. Pedro-Botet, F. Pedica, I. Cataldo, J. Marsillach, J. Joven, D. Girelli, and J. Camps. Paraoxonase-1 status in patients with hereditary hemochromatosis. J. Lipid Res. 2013. 54: 1484-1492.
C1 [Martinelli, Nicola; Busti, Fabiana; Girelli, Domenico] Univ Verona, Dept Med, I-37100 Verona, Italy.
   [Pedica, Federica; Cataldo, Ivana] Policlin GB Rossi, Hosp Verona, Dept Pathol, Verona, Italy.
   [Garcia-Heredia, Anabel; Roca, Helena; Mackness, Bharti; Mackness, Michael; Aragones, Gerard; Joven, Jorge; Camps, Jordi] Hosp Univ Sant Joan, Ctr Recerca Biomed, Reus, Catalonia, Spain.
   [Aranda, Nuria; Arija, Victoria] Univ Rovira & Virgili, Fac Med & Hlth Sci, Dept Prevent Med & Publ Hlth, E-43201 Reus, Catalonia, Spain.
   [Pedro-Botet, Juan] Hosp Mar, Dept Internal Med, Barcelona, Catalonia, Spain.
   [Marsillach, Judit] Univ Washington, Dept Med & Genome Sci, Seattle, WA 98195 USA.
C3 University of Verona; University of Verona; Azienda Ospedaliera
   Universitaria Integrata Verona; Universitat Rovira i Virgili; Hospital
   del Mar Research Institute; Hospital del Mar; University of Washington;
   University of Washington Seattle
RP Camps, J (corresponding author), Hosp Univ Sant Joan, Ctr Recerca Biomed, Reus, Catalonia, Spain.
EM jcamps@grupsagessa.com
RI Pedica, Federica/AAB-1557-2019; Aragonès, Gerard/AAJ-9150-2021; Girelli,
   Domenico/B-1183-2008; Marsillach, Judit/I-1329-2015; Camps,
   Jordi/AAG-3080-2020; Busti, Fabiana/K-8863-2019; Garcia-Heredia,
   Anabel/ABC-3161-2021; Joven, Jorge/B-3360-2016; Martinelli,
   Nicola/J-5622-2016; Aranda, Nuria/D-1942-2016; Aragones,
   Gerard/F-9673-2016
OI GIRELLI, Domenico/0000-0001-9684-1899; PEDICA,
   Federica/0000-0003-0168-4718; Joven, Jorge/0000-0003-2749-4541;
   Martinelli, Nicola/0000-0001-6465-5119; Aranda,
   Nuria/0000-0001-9708-747X; Arija, Victoria/0000-0002-1758-0975;
   Aragones, Gerard/0000-0001-8657-5726
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NR 52
TC 23
Z9 23
U1 0
U2 10
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0022-2275
EI 1539-7262
J9 J LIPID RES
JI J. Lipid Res.
PD MAY
PY 2013
VL 54
IS 5
BP 1484
EP 1492
DI 10.1194/jlr.P028977
PG 9
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 123MO
UT WOS:000317394300033
PM 23471031
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Toniazzo, AP
   Arcego, DM
   Lazzaretti, C
   Lampert, C
   Weis, SN
   Proto-Siqueira, R
   Krolow, R
   Dalmaz, C
AF Toniazzo, Ana Paula
   Arcego, Danusa M.
   Lazzaretti, Camilla
   Lampert, Carine
   Weis, Simone N.
   Proto-Siqueira, Rodrigo
   Krolow, Rachel
   Dalmaz, Carla
TI Sex-specific effects of prepubertal stress and high-fat diet on leptin
   signaling in rats
SO NUTRITION
LA English
DT Article
DE Thyroid hormones; JAK/STAT3 pathway; HPT axis; Obesity; Caloric
   efficiency
ID INDUCED OBESITY; OXIDATIVE CAPACITY; METABOLIC SYNDROME; ADIPOSE-TISSUE;
   ENERGY-BALANCE; RESISTANCE; ADIPOCYTOKINES; CONSEQUENCES; ADOLESCENCE;
   MAINTENANCE
AB Objective: Both stress exposure and high-fat diet (HFD) are contributors to the alarming prevalence of obesity. Leptin is secreted from adipose tissue and regulates appetite and body weight via the JAK-STAT3 pathway in the hypothalamus; it also regulates the hypothalamic-pituitary-thyroid axis, modulating energy homeostasis. Leptin signaling may be impaired by HFD intake, and here we investigate whether social isolation during the prepubertal period, associated with chronic HFD, can exert long-term effects on metabolic parameters in a sex-specific manner.
   Methods: Wistar male and female rats were divided into two groups (receiving standard chow or standard chow and HFD), which were subdivided into (1) exposed to social isolation during the prepubertal period or (2) not exposed.
   Results: HFD induced sex-specific effects on leptin signaling and on the hypothalamic-pituitary-thyroid axis; males receiving HFD presented increased T4 but a reduced T3:T4 ratio and higher caloric efficiency during development. A stress x diet interaction was noted for leptin signaling in males, where pSTAT3 was higher when these factors were applied together. On the other hand, females were more susceptible to early stress, which reduced pSTAT3 in the hypothalamus.
   Conclusion: Both stress during the prepubertal period and chronic consumption of HFD had long-term sex-specific effects on hormonal signaling related to energy balance. However, the effects of HFD were more pronounced in males, whereas prepubertal stress had greater effects on leptin signaling in females. (C) 2017 Elsevier Inc. All rights reserved.
C1 [Toniazzo, Ana Paula; Arcego, Danusa M.; Lampert, Carine; Weis, Simone N.; Krolow, Rachel; Dalmaz, Carla] Univ Fed Rio Grande do Sul, ICBS, Dept Bioquim, Porto Alegre, RS, Brazil.
   [Arcego, Danusa M.; Lazzaretti, Camilla; Dalmaz, Carla] UFRS, ICBS, PPG Neurociencias, Porto Alegre, RS, Brazil.
   [Proto-Siqueira, Rodrigo] Lab Antonello, Pelotas, RS, Brazil.
C3 Universidade Federal do Rio Grande do Sul; Universidade Federal do Rio
   Grande do Sul
RP Toniazzo, AP (corresponding author), Univ Fed Rio Grande do Sul, ICBS, Dept Bioquim, Porto Alegre, RS, Brazil.
EM Aninha.toniazzo84@gmail.com
RI dalmaz, carla/M-2069-2014; Toniazzo, Ana/H-1359-2016; Nardin Weis,
   Simone/F-5363-2014; Lampert, Carine/H-1349-2016
OI Nardin Weis, Simone/0000-0002-8705-8613; Krolow Santos Silva Bast,
   Rachel/0000-0001-6217-1647; Dalmaz, Carla/0000-0001-5397-2792; Lampert,
   Carine/0000-0003-3236-0900
FU Instituto nacional de ciencia e tecnologia (INCT) [INCT/CNPq
   465671/2014-4]; Conselho Nacional de Desenvolvimento Cientifico e
   Tecnologico (CNPq) [INCT/CNPq 465671/2014-4]
FX The authors do not declare any conflict of interest. This work was
   financially supported by Instituto nacional de ciencia e tecnologia
   (INCT) and the Conselho Nacional de Desenvolvimento Cientifico e
   Tecnologico (CNPq). INCT/CNPq 465671/2014-4.
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NR 45
TC 9
Z9 10
U1 0
U2 7
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0899-9007
EI 1873-1244
J9 NUTRITION
JI Nutrition
PD JUN
PY 2018
VL 50
BP 18
EP 25
DI 10.1016/j.nut.2017.10.018
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA GF3HF
UT WOS:000431835500003
PM 29518602
OA hybrid
DA 2025-06-11
ER

PT J
AU Hunsche, C
   Hernandez, O
   Gheorghe, A
   Díaz, LE
   Marcos, A
   De la Fuente, M
AF Hunsche, Caroline
   Hernandez, Oskarina
   Gheorghe, Alina
   Diaz, Ligia Esperanza
   Marcos, Ascension
   De la Fuente, Monica
TI Immune dysfunction and increased oxidative stress state in diet-induced
   obese mice are reverted by nutritional supplementation with
   monounsaturated and n-3 polyunsaturated fatty acids
SO EUROPEAN JOURNAL OF NUTRITION
LA English
DT Article
DE Obese mice; Monounsaturated fatty acids; n-3 Polyunsaturated fatty
   acids; Immune function; Oxidative stress
ID FISH-OIL SUPPLEMENTATION; OLIVE OIL; NEUTROPHIL FUNCTION; METABOLIC
   SYNDROME; MURINE MODEL; LIFE-SPAN; INFLAMMATION; MODULATION; SYSTEM;
   RICH
AB Obesity is associated with impaired immune defences and chronic low levels of inflammation and oxidation. In addition, this condition may lead to premature aging. The aim of the study was to evaluate the effects of a nutritional supplementation with monounsaturated and n-3 polyunsaturated fatty acids on several functions and oxidative stress parameters in peritoneal immune cells of obese mice, as well as on the life span of these animals.
   Obesity was induced in adult female ICR/CD1 by the administration of a high-fat diet (HFD) for 14 weeks. During the last 6 weeks of HFD feeding, one group of obese mice received the same HFD, supplemented with 1500 mg of 2-hydroxyoleic acid (2-OHOA) and another with 3000 mg of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). Several functions and oxidative stress parameters of peritoneal leukocytes were evaluated.
   The groups of obese mice treated with 2-OHOA or with EPA and DHA showed a significant improvement in several functions such as chemotaxis, phagocytosis, digestion capacity, Natural killer activity and lymphoproliferation in response to mitogens. All of these functions, which were decreased in obese mice, increased reaching similar levels to those found in non-obese controls. Both treatments also improved oxidative stress parameters such as xanthine oxidase activity, which decreased, catalase activity and glutathione levels, which increased.
   These data suggest that dietary supplementation with monounsaturated and n-3 polyunsaturated fatty acids could be an effective nutritional intervention to restore the immune response and oxidative stress state, which are impaired in obese mice.
C1 [Hunsche, Caroline; Hernandez, Oskarina; De la Fuente, Monica] Univ Complutense Madrid, Dept Anim Physiol 2, Fac Biol, Jose Antonio Novais St 2, Madrid 28040, Spain.
   [Hunsche, Caroline; Hernandez, Oskarina; De la Fuente, Monica] Hosp 12 Octubre I 12, Res Inst, Jose Antonio Novais St 2, Madrid 28040, Spain.
   [Gheorghe, Alina; Diaz, Ligia Esperanza; Marcos, Ascension] CSIC, Dept Metab & Nutr, Inst Food Sci Technol & Nutr ICTAN, Jose Antonio Novais St 10, Madrid 28040, Spain.
C3 Complutense University of Madrid; Hospital Universitario 12 de Octubre;
   Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Instituto
   de Ciencia y Tecnologia de Alimentos y Nutricion (ICTAN)
RP De la Fuente, M (corresponding author), Univ Complutense Madrid, Dept Anim Physiol 2, Fac Biol, Jose Antonio Novais St 2, Madrid 28040, Spain.; De la Fuente, M (corresponding author), Hosp 12 Octubre I 12, Res Inst, Jose Antonio Novais St 2, Madrid 28040, Spain.
EM mondelaf@bio.ucm.es
RI Prieto, Ligia/K-4887-2014; Sanchez, Ascension/K-4965-2014
FU Ministry of Science and Innovation [BFU2011-30336]; Research Group of
   Madrid Complutense University [910379ENEROINN]; Red Tematica de
   Investigacion Cooperativa en Envejecimiento y Fragilidad [RETICEF
   RD12/0043/0018]; FIS of Institute de Salud Carlos III-Fondo Europeo de
   Desarrollo Regional (ISCIII-FEDER) [PI15/01787]; PRONAOS study;
   BTSA-Applied Biotechnologies; CNP-q-Brazil
FX This work was supported by grants from Ministry of Science and
   Innovation (BFU2011-30336), the Research Group of Madrid Complutense
   University (910379ENEROINN), Red Tematica de Investigacion Cooperativa
   en Envejecimiento y Fragilidad (RETICEF RD12/0043/0018) and FIS
   (PI15/01787) of Institute de Salud Carlos III-Fondo Europeo de
   Desarrollo Regional (ISCIII-FEDER), the PRONAOS study and BTSA-Applied
   Biotechnologies S.L. Caroline Hunsche is the recipient of a PhD
   fellowship from CNP-q-Brazil.
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NR 52
TC 22
Z9 24
U1 0
U2 23
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1436-6207
EI 1436-6215
J9 EUR J NUTR
JI Eur. J. Nutr.
PD APR
PY 2018
VL 57
IS 3
BP 1123
EP 1135
DI 10.1007/s00394-017-1395-1
PG 13
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA FZ9YC
UT WOS:000427967500022
PM 28229279
DA 2025-06-11
ER

PT J
AU Winnik, S
   Gaul, DS
   Siciliani, G
   Lohmann, C
   Pasterk, L
   Calatayud, N
   Weber, J
   Eriksson, U
   Auwerx, J
   van Tits, LJ
   Lüscher, TF
   Matter, CM
AF Winnik, Stephan
   Gaul, Daniel S.
   Siciliani, Giovanni
   Lohmann, Christine
   Pasterk, Lisa
   Calatayud, Natacha
   Weber, Julien
   Eriksson, Urs
   Auwerx, Johan
   van Tits, Lambertus J.
   Luscher, Thomas F.
   Matter, Christian M.
TI Mild endothelial dysfunction in Sirt3 knockout mice fed a
   high-cholesterol diet: protective role of a novel C/EBP-β-dependent
   feedback regulation of SOD2
SO BASIC RESEARCH IN CARDIOLOGY
LA English
DT Article
DE Sirt3; Oxidative stress; SOD2; C/EBP-beta; Endothelial function
ID MANGANESE SUPEROXIDE-DISMUTASE; NITRIC-OXIDE SYNTHASE; NF-KAPPA-B;
   OXIDATIVE STRESS; CALORIC RESTRICTION; MITOCHONDRIAL DYSFUNCTION;
   CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; PROGNOSTIC VALUE;
   GENE-EXPRESSION
AB Sirtuin 3 (Sirt3) is an NAD(+)-dependent mitochondrial deacetylase associated with superoxide dismutase 2 (SOD2)-mediated protection from oxidative stress. We have reported accelerated weight gain and impaired metabolic flexibility in atherosclerotic Sirt3(-/-) mice. Oxidative stress is a hallmark of endothelial dysfunction. Yet, the role of Sirt3 in this context remains unknown. Thus, we aimed to unravel the effects of endogenous Sirt3 on endothelial function and oxidative stress. Knockdown of Sirt3 in human aortic endothelial cells (HAEC) increased intracellular mitochondrial superoxide accumulation, as assessed by electron spin resonance spectroscopy and fluorescence imaging. Endothelium-dependent relaxation of aortic rings from Sirt3(-/-) mice exposed to a normal diet did not differ from wild-type controls. However, following 12 weeks of high-cholesterol diet and increasing oxidative stress, endothelial function of Sirt3(-/-) mice was mildly impaired compared with wild-type controls. Relaxation was restored upon enhanced superoxide scavenging using pegylated superoxide dismutase. Knockdown of Sirt3 in cultured HAEC diminished SOD2 specific activity, which was compensated for by a CCAAT/enhancer binding protein beta (C/EBP-beta)-dependent transcriptional induction of SOD2. Abrogation of this feedback regulation by simultaneous knockdown of C/EBP-beta and Sirt3 exacerbated mitochondrial superoxide accumulation and culminated into endothelial cell death upon prolonged culture. Taken together, Sirt3 deficiency induces a mild, superoxide-dependent endothelial dysfunction in mice fed a high-cholesterol diet. In cultured endothelial cells, a novel C/EBP-beta-dependent rescue mechanism maintains net SOD2 activity upon transient knockdown of Sirt3.
C1 [Winnik, Stephan; Luscher, Thomas F.; Matter, Christian M.] Univ Zurich Hosp, Univ Heart Ctr Zurich, Dept Cardiol, Raemistr 100, CH-8091 Zurich, Switzerland.
   [Winnik, Stephan; Gaul, Daniel S.; Siciliani, Giovanni; Lohmann, Christine; Pasterk, Lisa; Calatayud, Natacha; Weber, Julien; Eriksson, Urs; van Tits, Lambertus J.; Luscher, Thomas F.; Matter, Christian M.] Univ Zurich, Ctr Mol Cardiol, Schlieren, Switzerland.
   [Pasterk, Lisa] Med Univ Graz, Inst Expt & Clin Pharmacol, Graz, Austria.
   [Eriksson, Urs] GZO Reg Hlth Ctr Wetzikon, Dept Med, Div Cardiol, Wetzikon, Switzerland.
   [Auwerx, Johan] Ecole Polytech Fed Lausanne, Sch Life Sci, Lab Integrat Syst Physiol, Lausanne, Switzerland.
   [Gaul, Daniel S.; Luscher, Thomas F.; Matter, Christian M.] Univ Zurich, Zurich Ctr Integrat Human Physiol, Zurich, Switzerland.
C3 University of Zurich; University Zurich Hospital; Medical University of
   Graz; Swiss School of Public Health (SSPH+); Swiss Federal Institutes of
   Technology Domain; Ecole Polytechnique Federale de Lausanne; University
   of Zurich; Zurich Center Integrative Human Physiology (ZIHP)
RP Winnik, S; Matter, CM (corresponding author), Univ Zurich Hosp, Univ Heart Ctr Zurich, Dept Cardiol, Raemistr 100, CH-8091 Zurich, Switzerland.; Winnik, S; Matter, CM (corresponding author), Univ Zurich, Ctr Mol Cardiol, Schlieren, Switzerland.
EM stephan.winnik@usz.ch; christian.matter@usz.ch
RI Winnik, Stephan/D-4739-2009; Auwerx, Johan/ABE-9307-2021
OI Eriksson, Urs/0000-0003-1217-9696; Winnik, Stephan/0000-0002-1277-5132;
   Auwerx, Johan/0000-0002-5065-5393
FU Swiss National Science Foundation [31003A-140780, 310030-135815, 146923,
   140336]; National Institute of Health (US) [R01AG043930]; Systems X
   (SysX.ch); University Research Priority Program Integrative Human
   Physiology at the University of Zurich; University of Zurich; Ecole
   Polytechnique Federale de Lausanne; Zurich Heart House-Foundation for
   Cardiovascular Research, Zurich, Switzerland; Austrian Science Fund
   (FWF) [W1241] Funding Source: Austrian Science Fund (FWF)
FX This work was funded by the Swiss National Science Foundation to JA
   (31003A-140780), to TFL (310030-135815), and to CMM (146923, 140336),
   the National Institute of Health (US) to JA (R01AG043930), Systems X
   (SysX.ch) to JA (2013-15), the University Research Priority Program
   Integrative Human Physiology at the University of Zurich to TFL and CMM,
   Matching Funds by the University of Zurich to SW and CMM, the Ecole
   Polytechnique Federale de Lausanne to JA, and the Zurich Heart
   House-Foundation for Cardiovascular Research, Zurich, Switzerland.
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NR 60
TC 29
Z9 32
U1 1
U2 5
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0300-8428
EI 1435-1803
J9 BASIC RES CARDIOL
JI Basic Res. Cardiol.
PD MAR
PY 2016
VL 111
IS 3
AR 33
DI 10.1007/s00395-016-0552-7
PG 15
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA DQ1DY
UT WOS:000378942800005
PM 27071400
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Kim, YW
   Kim, YM
   Yang, YM
   Kim, TH
   Hwang, SJ
   Lee, JR
   Kim, SC
   Kim, SG
AF Kim, Young Woo
   Kim, Young Mi
   Yang, Yoon Mee
   Kim, Tae Hyun
   Hwang, Se Jin
   Lee, Jong Rok
   Kim, Sang Chan
   Kim, Sang Geon
TI Inhibition of SREBP-1c-mediated hepatic steatosis and oxidative stress
   by sauchinone, an AMPK-activating lignan in Saururus chinensis
SO FREE RADICAL BIOLOGY AND MEDICINE
LA English
DT Article
DE High-fat diet; Hepatic steatosis; Sauchinone; oxidative stress;
   SREBP-1c; Free radicals
ID HIGH-FAT DIET; ELEMENT-BINDING PROTEIN-1C; NITRIC-OXIDE SYNTHASE; S6
   KINASE-1 PATHWAY; X-RECEPTOR; METABOLIC SYNDROME; NONALCOHOLIC
   STEATOHEPATITIS; MITOCHONDRIAL DYSFUNCTION; LIVER-DISEASE; ALPHA
AB Sauchinone, as an AMP-activated kinase (AMPK)-activating lignan in Saururus chinensis. has been shown to prevent iron-induced oxidative stress and liver Injury Sterol regulatory element binding protein-1c (SREBP-1c) plays a key role in hepatic steatosis, which promotes oxidative stress in obese subjects Previously, we identified the role of AMPK in liver X receptor-alpha (LXR alpha)-mediated SREBP-1c-dependent lipogenesis Because sauchinone as an antioxidant has the ability to activate AMPK, this study investigated its effects on SREBP-1c-dependent lipogenesis in hepatocytes and in high-fat diet (HFD)-induced hepatic steatosis and oxidative injury. Sauchinone prevented the ability of an LXR alpha agonist (T0901317) to activate SREBP-1c. repressing transcription of the fatty acid synthase, acetyl-CoA carboxylase, stearoyl-CoA desaturase-1, ATP-binding cassette transporter A1, and LXRa genes. Consistent with this, an HFD in mice caused fat accumulation in the liver with SREBP-1c induction, which was attenuated by sauchinone treatment Also, sauchinone had the ability to inhibit oxidative stress its shown by decreases in thiobarbituric acid-reactive substance formation, nitrotyrosinylation, and 4-hydroxynonenal production. Moreover. it prevented not only the liver Injury, but also the AMPK inhibition elicited by HFD feeding These results demonstrate that sauchinone has the capability to inhibit LXR alpha-mediated SREBP-is induction and SREBP-1c-dependent hepatic steatosis, thereby protecting hepatocytes from oxidative stress induced by fat accumulation. (C) 2009 Elseviei Inc All rights reserved.
C1 [Kim, Young Woo; Kim, Young Mi; Yang, Yoon Mee; Kim, Tae Hyun; Kim, Sang Geon] Seoul Natl Univ, Coll Pharm, Seoul 151742, South Korea.
   [Hwang, Se Jin] Hanyang Univ, Coll Med, Seoul 133791, South Korea.
   [Lee, Jong Rok; Kim, Sang Chan] Daegu Haany Univ, Coll Oriental Med, Taegu, South Korea.
C3 Seoul National University (SNU); Hanyang University; Daegu Haany
   University
RP Kim, SG (corresponding author), Seoul Natl Univ, Coll Pharm, Seoul 151742, South Korea.
RI Kim, Sang Chan/IUQ-5763-2023; Kim, Tae/AAG-9722-2020; Kim,
   Woo/A-8216-2019; Lee, Jinseok/ACF-1247-2022
OI Yang, Yoon Mee/0000-0003-4281-9906; Kim, Tae Hyun/0000-0002-8472-1846;
   Kim, Sang Chan/0000-0003-0515-0764
FU government of Korea (MEST) [2009-0063233]
FX This work was supported by a National Research Foundation of Korea grant
   funded by the government of Korea (MEST No. 2009-0063233)
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NR 39
TC 73
Z9 79
U1 0
U2 25
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0891-5849
EI 1873-4596
J9 FREE RADICAL BIO MED
JI Free Radic. Biol. Med.
PD FEB 15
PY 2010
VL 48
IS 4
BP 567
EP 578
DI 10.1016/j.freeradbiomed.2009.12.006
PG 12
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 551UH
UT WOS:000274235500012
PM 20005944
DA 2025-06-11
ER

PT J
AU Katsa, ME
   Kostopoulou, E
   Nomikos, T
   Ioannidis, A
   Sarris, V
   Papadogiannis, S
   Spiliotis, BE
   Gil, APR
AF Katsa, Maria Efthymia
   Kostopoulou, Eirini
   Nomikos, Tzortzis
   Ioannidis, Anastasios
   Sarris, Vasileios
   Papadogiannis, Spyridon
   Spiliotis, Bessie E.
   Rojas Gil, Andrea Paola
TI The Response of Antioxidant Enzymes and Antiapoptotic Markers to an Oral
   Glucose Tolerance Test (OGTT) in Children and Adolescents with Excess
   Body Weight
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE impaired glucose tolerance; children; overweight; oxidative stress;
   apoptosis
ID GLUTATHIONE-PEROXIDASE 3; PLASMA GHRELIN LEVELS; OXIDATIVE STRESS;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; DIABETES-MELLITUS;
   ADIPOSE-TISSUE; SERUM-LEVELS; OBESITY; EXPRESSION
AB Oxidative stress and apoptosis are involved in the pathogenesis of obesity-related diseases. This observational study investigates the antioxidant and apoptotic markers response to an oral glucose tolerance test (OGTT) in a population of overweight children and adolescents, with normal (NGT) or impaired glucose tolerance (IGT). Glucose, insulin, and C-peptide concentrations, as well as oxidative stress (SOD, GPx3) and apoptotic markers (Apo1fas, cck18), were determined at T = 0, 30, 60, 90, 120, and 180 min after glucose intake during OGTT. The lipid profile, thyroid function, insulin-like growth factor1, leptin, ghrelin, and adiponectin were also measured at baseline. The 45 participants, with a mean age of 12.15 (+/- 2.3) years old, were divided into two subcategories: those with NG tau (n = 31) and those with IGT (n = 14). The area under the curve (AUC) of glucose, insulin, and C-peptide was greater in children with IGT; however, only glucose differences were statistically significant. SOD and GPx3 levels were higher at all time points in the IGT children. Apo1fas and cck18 levels were higher in the NGT children at most time points, whereas Adiponectin was lower in the IGT group. Glucose increased during an OGTT accompanied by a simultaneous increase in antioxidant factors, which may reflect a compensatory mechanism against the impending increase in oxidative stress in children with IGT.
C1 [Katsa, Maria Efthymia; Ioannidis, Anastasios; Sarris, Vasileios; Papadogiannis, Spyridon; Rojas Gil, Andrea Paola] Univ Peloponnese, Fac Hlth Sci, Dept Nursing, Lab Basic Hlth Sci, Tripoli 22100, Greece.
   [Katsa, Maria Efthymia; Nomikos, Tzortzis] Harokopio Univ, Sch Hlth Sci & Educ, Dept Nutr & Dietet, Athens 17676, Greece.
   [Kostopoulou, Eirini; Spiliotis, Bessie E.] Univ Patras, Sch Med, Dept Pediat, Div Pediat Endocrinol, Patras 26504, Greece.
C3 University of Peloponnese; Harokopio University Athens; University of
   Patras
RP Gil, APR (corresponding author), Univ Peloponnese, Fac Hlth Sci, Dept Nursing, Lab Basic Hlth Sci, Tripoli 22100, Greece.
EM merfykat@hua.gr; eirini.kost@gmail.com; tnomikos@hua.gr; tasobi@uop.gr;
   vsarris@di.uoa.gr; spirospapadogiannis@gmail.com; besspil@gmail.com;
   arojas@uop.gr
RI Gil, Andrea/AAS-8328-2021; Kostopoulou, Eirini/AAY-7878-2020
OI Spiliotis, Bessie E./0000-0001-7922-4012; IOANNIDIS,
   ANASTASIOS/0000-0003-1880-7366; Papadogiannis,
   Spyridon/0009-0008-5287-7548
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NR 70
TC 1
Z9 1
U1 0
U2 2
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD NOV
PY 2023
VL 24
IS 22
AR 16517
DI 10.3390/ijms242216517
PG 17
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA AT5X5
UT WOS:001120731200001
PM 38003707
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Yamada, S
   Kawaguchi, H
   Yamada, T
   Guo, X
   Matsuo, K
   Hamada, T
   Miura, N
   Tasaki, T
   Tanimoto, A
AF Yamada, Sohsuke
   Kawaguchi, Hiroaki
   Yamada, Tomonobu
   Guo, Xin
   Matsuo, Kei
   Hamada, Taiji
   Miura, Naoki
   Tasaki, Takashi
   Tanimoto, Akihide
TI Cholic Acid Enhances Visceral Adiposity, Atherosclerosis and
   Nonalcoholic Fatty Liver Disease in Microminipigs
SO JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
LA English
DT Article
DE Cholic acid; Microminipig; Nonalcoholic fatty liver disease; Oxidative
   stress; Metabolic syndrome
ID HISTAMINE-RECEPTORS; LIPID-METABOLISM; BILE-ACIDS; STEATOHEPATITIS;
   CHOLESTEROL; APOPTOSIS; MODEL; PROTECTS; TISSUE
AB Aim: We have recently established a novel swine model for studies of atherosclerosis using Microminipigs (TM) (mu MPs) fed a high-fat/high-cholesterol diet (HcD). Using this swine model, we re-evaluated the effects of dietary cholic acid (CA) on serum lipid profile, atherosclerosis and hepatic injuries.
   Methods: The mu MPs were fed HcD supplemented with 0.7% CA (HcD+CA) for eight weeks, and the effect of CA on serum lipoprotein levels, expression of oxidative stress markers, adiposity and lesion formation in the aorta, liver, and other organs was investigated.
   Results: The HcD+CA-fed group exhibited more visceral adiposity, progression of atherosclerosis and higher serum levels of oxidative stress markers than the HcD-fed group, even though they showed similar serum lipid levels. The liver demonstrated increased lipid accumulation, higher expression of oxidative stress markers, accelerated activation of foamy Kupffer cells and stellate cells, and increased hepatocyte apoptosis, indicating non-alcoholic fatty liver disease (NAFLD). Intriguingly, foamy macrophage mobilization was observed in various organs, including the reticuloendothelial system, pulmonary capillary vessels and skin very often in HcD+CA-fed mu MPs.
   Conclusion: To our knowledge, this is the first large animal model, in which visceral obesity, NAFLD and atherosclerosis are concomitantly induced by dietary manipulation. These data suggest the detrimental effects of CA, potentially through local and systemic activation of oxidative stress-induced signaling to macrophage mobilization, on the acceleration of visceral adiposity, atherosclerosis and NAFLD.
C1 [Yamada, Sohsuke; Guo, Xin; Matsuo, Kei; Hamada, Taiji; Tasaki, Takashi; Tanimoto, Akihide] Kagoshima Univ, Grad Sch Med & Dent Sci, Dept Pathol, 8-35-1 Sakuragaoka, Kagoshima 8908544, Japan.
   [Kawaguchi, Hiroaki] Kagoshima Univ, Grad Sch Med & Dent Sci, Dept Hyg & Hlth Promot Med, Kagoshima, Japan.
   [Yamada, Tomonobu] Shin Nippon Biomed Labs Ltd, Kagoshima, Japan.
   [Miura, Naoki] Kagoshima Univ, Joint Fac Vet Med, Vet Teaching Hosp, Kagoshima, Japan.
C3 Kagoshima University; Kagoshima University; Shin Nippon Biomedical
   Laboratories Ltd.; Kagoshima University
RP Tanimoto, A (corresponding author), Kagoshima Univ, Grad Sch Med & Dent Sci, Dept Pathol, 8-35-1 Sakuragaoka, Kagoshima 8908544, Japan.
EM akit09@m3.kufm.kagoshima-u.ac.jp
RI Miura, Naoki/O-6997-2016; Miura, Naoki/A-5734-2010
OI Miura, Naoki/0000-0002-4625-5231
FU Kodama Memorial Fund for Medical Research, Kagoshima, Japan; Ministry of
   Health, Labour and Welfare of Japan [33361105]; Ministry of Education,
   Culture, Sports, Science and Technology, Tokyo, Japan [AS2316907E];
   Suzuken Memorial Foundation; SENSHIN Medical Research Foundation;
   Grants-in-Aid for Scientific Research [16K08023, 16K08750, 16H05845]
   Funding Source: KAKEN
FX This work was supported in part by a grant from the Kodama Memorial Fund
   for Medical Research, Kagoshima, Japan (to S.Y.), Health Labour Sciences
   Research Grant (No. 33361105) from the Ministry of Health, Labour and
   Welfare of Japan (to A.T.), the Adaptable and Seamless Technology
   Transfer Program Grant (A-Step No. AS2316907E) from the Ministry of
   Education, Culture, Sports, Science and Technology, Tokyo, Japan (to
   A.T. and H.K.), the Suzuken Memorial Foundation (to N.M.) and the
   SENSHIN Medical Research Foundation (to H.K. and N.H.).
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NR 46
TC 24
Z9 28
U1 3
U2 10
PU JAPAN ATHEROSCLEROSIS SOC
PI TOKYO
PA NICHINAI-KAIKAN B1, 3-28-8 HONGO BUNKYO-KU, TOKYO, 113-0033, JAPAN
SN 1340-3478
EI 1880-3873
J9 J ATHEROSCLER THROMB
JI J. Atheroscler. Thromb.
PY 2017
VL 24
IS 11
BP 1150
EP 1166
DI 10.5551/jat.39909
PG 17
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA FT2PU
UT WOS:000422988900009
PM 28496045
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Kushwah, AS
   Das Gupta, G
AF Kushwah, Ajay Singh
   Das Gupta, Ghanshyam
TI QUERCETIN AMELIORATE INSULIN RESISTANCE CONCOMITANT EARLY CARDIOVASCULAR
   CHANGES IN EXPERIMENTAL RATS
SO ACTA POLONIAE PHARMACEUTICA
LA English
DT Article
DE quercetin; myocardium; oxidative stress; high-fructose diet; insulin
   resistance; 5 ' adenosine monophosphate-activated protein kinase
ID ACTIVATED PROTEIN-KINASE; EMERGING DRUG TARGET; METABOLIC SYNDROME;
   OXIDATIVE STRESS; VASCULAR DYSFUNCTION; FLAVONOID QUERCETIN; HIGH-FAT;
   FRUCTOSE; GLUCOSE; MICE
AB Quercetin is a dietary flavonoid found in a wide range of fruits and vegetables: it has diverse biological activities, possesses beneficial effects in ameliorating diabetic complications, apart from the effect of quercetin on fructose feed induced insulin resistance (IR) linked cardiac dysfunction have not been entirely revealed. This study aspires to explore the effect of quercetin on metabolism, oxidative stress, cardiomyocytes damage and cardiac function in IR state. Wistar rats either sex weighing 220-250 g (n = 8), were divided into four groups, kept on either control diet and high fructose diet and supplement with a quercetin as a test drug and metformin as a standard, at the dose of 50 and 200 mg/kg; p.o., respectively. Daily measured body weight, feed, and water intake for 35 days, Oral glucose tolerance test (OGIT) performed in animals on the 32nd day. At end of the study (36th day), measured hemodynamic parameters after that estimation of various biochemical parameters. Finally, the animals were sacrificed for isolation of tissues and measured heart weight, the oxidative stress level of heart and histopathological changes. Treatment of quercetin with fructose-fed ameliorated all the parameters revile by the contrast of IR rats. The outcome of quercetin associated improves insulin sensitivity. normalized lipid profile, abolish hemodynamic changes, oxidative stress and cardiac injury markers within fructose-fed, and lesser histopathological changes were observed in contrast with IR rats. These beneficial effects of quercetin mediated by improving insulin sensitivity and metabolism; reduced oxidative stress could potentially be used to ameliorate the myocardial damage.
C1 [Kushwah, Ajay Singh] IK Gujral Punjab Tech Univ, Kapurthala 144603, Punjab, India.
   [Kushwah, Ajay Singh] ASBASJSM Coll Pharm, Dept Pharmacol, Ropar 140111, Punjab, India.
   [Das Gupta, Ghanshyam] ISF Coll Pharm, Ferozepur GT Rd, Moga 142001, Punjab, India.
C3 I. K. Gujral Punjab Technical University; ISF College of Pharmacy
RP Kushwah, AS (corresponding author), IK Gujral Punjab Tech Univ, Kapurthala 144603, Punjab, India.; Kushwah, AS (corresponding author), ASBASJSM Coll Pharm, Dept Pharmacol, Ropar 140111, Punjab, India.
EM kushwah_ph05@yahoo.co.in
RI Kushwah, Ajay/K-1130-2019; Gupta, Ghanshyam Das/KFR-9283-2024
OI Gupta, Ghanshyam Das/0000-0002-5377-1082; Kushwah, Ajay
   Singh/0000-0003-0559-7670
CR Ahn J, 2008, BIOCHEM BIOPH RES CO, V373, P545, DOI 10.1016/j.bbrc.2008.06.077
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NR 42
TC 2
Z9 2
U1 0
U2 2
PU POLSKIE TOWARZYSTWO FARMACEUTYCZNE
PI WARSAW
PA DLUGA 16, 00-238 WARSAW, POLAND
SN 0001-6837
EI 2353-5288
J9 ACTA POL PHARM
JI ACTA POL. PHARM.
PD JUL-AUG
PY 2018
VL 75
IS 4
BP 977
EP 987
DI 10.32383/appdr/80887
PG 11
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA GW8LY
UT WOS:000447231500016
OA Bronze
DA 2025-06-11
ER

PT J
AU Seo, M
   Islam, SA
   Moon, SS
AF Seo, M.
   Islam, S. A.
   Moon, S. -S.
TI Acute anti-obesity effects of intracerebroventricular 11-HSD1 inhibitor
   administration in diet-induced obese mice
SO JOURNAL OF NEUROENDOCRINOLOGY
LA English
DT Article
DE 11 beta-HSD1; endoplasmic reticulum stress; hypothalamus; insulin;
   leptin; obesity
ID 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1; ENDOPLASMIC-RETICULUM
   STRESS; FOOD-INTAKE; METABOLIC SYNDROME; SIGNAL TRANSDUCER; BODY-WEIGHT;
   LEPTIN; NEURONS; EXPRESSION; ENERGY
AB The hypothalamus is the regulatory centre of both appetite and energy balance and endoplasmic reticulum (ER) stress in the hypothalamus is involved in the pathogenesis of obesity. Recently, inhibition of 11 hydroxysteroid dehydrogenase type1 (11-HSD1) was reported to have an anti-obesity effect by reducing fat mass. However, the link between the role of 11-HSD1 in the hypothalamus and obesity has yet to be determined. In the present study, embryonal primary hypothalamic neurones and high-fat diet (HFD) fed mice were used to investigate the anorexigenic effects of 11-HSD1 inhibitors both in vitro and in vivo. In hypothalamic neurones, carbenoxolone (a non selecitve 11-HSD inhibitor) alleviated ER stress and ER stress-induced neuropeptide alterations. In HFD mice, i.c.v. administration of carbenoxolone or KR67500 (nonselective and selective 11-HSD1 inhibitors, respectively) was associated with less weight gain compared to control mice for 24hours after treatment, presumably by reducing food intake. Furthermore, glucose regulated protein (Grp78), spliced X-box binding protein (Xbp-1s), c/EBP homologous protein (chop) and ER DnaJ homologue protein (Erdj4) expression was decreased in the hypothalami of mice administrated 11-HSD1 inhibitors compared to controls. Conversely, the phosphorylation of protein kinase B (PKB/Akt), signal transducer and activator of transcription 3 (Stat3), mitogen-activated protein kinase (MAPK/ERK) and S6 kinase1 (S6K1) in the hypothalamus was induced more in mice treated using the same regimes. In conclusion, acute 11-HSD1 inhibition in the hypothalamus could reduce food intake by decreasing ER stress and increasing insulin, leptin, and mammalian target of rapamycin complex 1 (mTORC1) signalling.
C1 [Seo, M.; Moon, S. -S.] Dongguk Univ, Med Inst, Gyeongju, South Korea.
   [Seo, M.] Rural Dev Adm, Natl Inst Agr Sci, Dept Agr Biol, Wanju Gun, South Korea.
   [Islam, S. A.; Moon, S. -S.] Dongguk Univ, Dept Internal Med, Coll Med, Gyeongju, South Korea.
C3 Dongguk University; National Institute of Agricultural Sciences; Rural
   Development Administration (RDA), Republic of Korea; Dongguk University
RP Moon, SS (corresponding author), Dongguk Univ, Dept Internal Med, Coll Med, Gyeongju, South Korea.
EM drmoonss@hanmail.net
FU Basic Science Research Program of the National Research Foundation (NRF)
   of Korea; Ministry of Education [2014R1A1A2054808]; Younghonam Diabetes
   Association; Dongguk University research fund; Korean Diabetes
   Association
FX The Basic Science Research Program of the National Research Foundation
   (NRF) of Korea; The Ministry of Education, Grant/Award Number:
   2014R1A1A2054808; Younghonam Diabetes Association; the Dongguk
   University research fund; The Korean Diabetes Association
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NR 44
TC 2
Z9 3
U1 0
U2 13
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0953-8194
EI 1365-2826
J9 J NEUROENDOCRINOL
JI J. Neuroendocrinol.
PD MAR
PY 2018
VL 30
IS 3
AR e12580
DI 10.1111/jne.12580
PG 13
WC Endocrinology & Metabolism; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology
GA GB1ZK
UT WOS:000428850000006
PM 29418022
DA 2025-06-11
ER

PT J
AU Othman, EM
   Oli, RG
   Arias-Loza, PA
   Kreissl, MC
   Stopper, H
AF Othman, Eman Maher
   Oli, R. G.
   Arias-Loza, Paula-Anahi
   Kreissl, Michael C.
   Stopper, Helga
TI Metformin Protects Kidney Cells From Insulin-Mediated Genotoxicity In
   Vitro and in Male Zucker Diabetic Fatty Rats
SO ENDOCRINOLOGY
LA English
DT Article
ID DNA-DAMAGE; OXIDATIVE STRESS; BREAST-CANCER; ANTIOXIDANT PROPERTIES;
   METABOLIC SYNDROME; ANTIDIABETIC DRUG; RISK; HYPERINSULINEMIA;
   APOPTOSIS; COLON
AB Hyperinsulinemia is thought to enhance cancer risk. A possible mechanism is induction of oxidative stress and DNA damage by insulin, Here, the effect of a combination of metformin with insulin was investigated in vitro and in vivo. The rationales for this were the reported antioxidative properties of metformin and the aim to gain further insights into the mechanisms responsible for protecting the genome from insulin-mediated oxidative stress and damage. The comet assay, a micronucleus frequency test, and a mammalian gene mutation assay were used to evaluate the DNA damage produced by insulin alone or in combination with metformin. For analysis of antioxidant activity, oxidative stress, and mitochondrial disturbances, the cell-free ferric reducing antioxidant power assay, the superoxide-sensitive dye dihydroethidium, and the mitochondrial membrane potential-sensitive dye 5,5',6,6' tetrachloro-1,1',3,3'-tetraethylbenzimidazol-carbocyanine iodide were applied. Accumulation of p53 and pAKT were analyzed. As an in vivo model, hyperinsulinemic Zucker diabetic fatty rats, additionally exposed to insulin during a hyperinsulinemic-euglycemic clamp, were treated with metformin. In the rat kidney samples, dihydroethidium staining, p53 and pAKT analysis, and quantification of the oxidized DNA base 8-oxo-7,8-dihydro-2'-deoxyguanosine were performed. Metformin did not show intrinsic antioxidant activity in the cell-free assay, but protected cultured cells from insulin-mediated oxidative stress, DNA damage, and mutation. Treatment of the rats with metformin protected their kidneys from oxidative stress and genomic damage induced by hyperinsulinemia. Metformin may protect patients from genomic damage induced by elevated insulin levels. This may support efforts to reduce the elevated cancer risk that is associated with hyperinsulinemia.
C1 [Othman, Eman Maher; Oli, R. G.; Stopper, Helga] Univ Wurzburg, Inst Pharmacol & Toxicol, D-97078 Wurzburg, Germany.
   [Othman, Eman Maher] Univ El Minia, Fac Pharm, Dept Analyt Chem, Al Minya 61519, Egypt.
   [Arias-Loza, Paula-Anahi; Kreissl, Michael C.] Univ Hosp Wurzburg, Dept Nucl Med, D-97080 Wurzburg, Germany.
C3 University of Wurzburg; Egyptian Knowledge Bank (EKB); Minia University;
   University of Wurzburg
RP Stopper, H (corresponding author), Univ Wurzburg, Dept Toxicol, Versbacher Str 9, D-97078 Wurzburg, Germany.
EM stopper@toxi.uni-wuerzburg.de
RI Othman, Eman/LBI-5240-2024; Kreissl, Michael Christoph/GRR-9938-2022
OI Kreissl, Michael Christoph/0000-0001-5905-6015; Arias-Loza,
   Anahi-Paula/0000-0003-4048-4719; Othman, Eman M./0000-0003-4781-9745
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NR 50
TC 19
Z9 21
U1 0
U2 6
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0013-7227
EI 1945-7170
J9 ENDOCRINOLOGY
JI Endocrinology
PD FEB
PY 2016
VL 157
IS 2
BP 548
EP 559
DI 10.1210/en.2015-1572
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA DD5LT
UT WOS:000369965900014
PM 26636185
OA Bronze
DA 2025-06-11
ER

PT J
AU Matsuzawa, N
   Takamura, T
   Kurita, S
   Misu, H
   Ando, H
   Yokoyama, M
   Honda, M
   Zen, Y
   Nakanuma, Y
   Miyamoto, KI
   Kaneko, S
AF Matsuzawa, Naoto
   Takamura, Toshinari
   Kurita, Seiichiro
   Misu, Hirofumi
   Ando, Hitoshi
   Yokoyama, Masayoshi
   Honda, Masao
   Zen, Yoh
   Nakanuma, Yasuni
   Miyamoto, Ken-Ichi
   Kaneko, Shuichi
TI Lipid-induced oxidative stress causes steatohepatitis in mice fed an
   atherogenic diet
SO HEPATOLOGY
LA English
DT Article
ID NONALCOHOLIC FATTY LIVER; TRANSCRIPTION FACTOR; INSULIN-RESISTANCE;
   HEPATIC-FIBROSIS; MICROARRAY DATA; NADPH OXIDASE; CHOLESTEROL; RECEPTOR;
   EXPRESSION; BINDING
AB Recently, nonalcoholic steatohepatitis (NASH) was found to be correlated with cardiovascular disease events independently of the metabolic syndrome. The aim of this study was to investigate whether an atherogenic (Ath) diet induces the pathology of steatohepatitis necessary for the diagnosis of human NASH and how cholesterol and triglyceride alter the hepatic gene expression profiles responsible for oxidative stress. We investigated the liver pathology and plasma and hepatic lipids of mice fed the Ath diet. The hepatic gene expression profile was examined with microarrays and real-time polymerase chain reactions. The Ath diet induced dyslipidemia, lipid peroxidation, and stellate cell activation in the liver and finally caused precirrhotic steatohepatitis after 24 weeks. Cellular ballooning, a necessary histological feature defining human NASH, was observed in contrast to existing animal models. The addition of a high-fat component to the Ath diet caused hepatic insulin resistance and further accelerated the pathology of steatohepatitis. A global gene expression analysis revealed that the Ath diet up-regulated the hepatic expression levels of genes for fatty acid synthesis, oxidative stress, inflammation, and fibrogenesis, which were further accelerated by the addition of a high-fat component. Conversely, the high-fat component down-regulated the hepatic gene expression of antioxidant enzymes and might have increased oxidative stress. Conclusion: The Ath diet induces oxidative stress and steatohepatitis with cellular ballooning. The high-fat component induces insulin resistance, down-regulates genes for antioxidant enzymes, and further aggravates the steatohepatitis. This model suggests the critical role of lipids in causing oxidative stress and insulin resistance leading to steatohepatitis.
C1 Kanazawa Univ, Grad Sch Med Sci, Dept Dis Control & Homeostasis, Kanazawa, Ishikawa 9208641, Japan.
   Kanazawa Univ, Grad Sch Nat Sci & Technol, Dept Pharm & Hlth Sci, Kanazawa, Ishikawa 9208641, Japan.
   Kanazawa Univ, Grad Sch Med Sci, Dept Human Pathol, Kanazawa, Ishikawa 9208641, Japan.
C3 Kanazawa University; Kanazawa University; Kanazawa University
RP Takamura, T (corresponding author), Kanazawa Univ, Grad Sch Med Sci, Dept Dis Control & Homeostasis, 13-1 Takara Machi, Kanazawa, Ishikawa 9208641, Japan.
EM ttakamura@m-kanazawa.jp
RI Nagata, Naoto/D-9261-2012; Ando, Hitoshi/O-8199-2016
OI Nagata, Naoto/0000-0002-2389-2334; Ando, Hitoshi/0000-0001-6179-9993
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NR 46
TC 436
Z9 468
U1 1
U2 35
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0270-9139
EI 1527-3350
J9 HEPATOLOGY
JI Hepatology
PD NOV
PY 2007
VL 46
IS 5
BP 1392
EP 1403
DI 10.1002/hep.21874
PG 12
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 228BF
UT WOS:000250701200013
PM 17929294
DA 2025-06-11
ER

PT J
AU Munteanu, C
   Kotova, P
   Schwartz, B
AF Munteanu, Camelia
   Kotova, Polina
   Schwartz, Betty
TI Impact of Olive Oil Components on the Expression of Genes Related to
   Type 2 Diabetes Mellitus
SO NUTRIENTS
LA English
DT Review
DE olive oil; type 2 diabetes mellitus; oxidative stress; inflammation;
   polyphenols
ID INDUCED INSULIN-RESISTANCE; UNSATURATED FATTY-ACIDS; ALPHA-LINOLENIC
   ACID; PROTECTS BETA-CELLS; SKELETAL-MUSCLE; MEDITERRANEAN DIET;
   METABOLIC SYNDROME; ADIPOSE-TISSUE; OXIDATIVE STRESS; STEARIC-ACID
AB Type 2 diabetes mellitus (T2DM) is a multifactorial metabolic disorder characterized by insulin resistance and beta cell dysfunction, resulting in hyperglycemia. Olive oil, a cornerstone of the Mediterranean diet, has attracted considerable attention due to its potential health benefits, including reducing the risk of developing T2DM. This literature review aims to critically examine and synthesize existing research regarding the impact of olive oil on the expression of genes relevant to T2DM. This paper also seeks to provide an immunological and genetic perspective on the signaling pathways of the main components of extra virgin olive oil. Key bioactive components of olive oil, such as oleic acid and phenolic compounds, were identified as modulators of insulin signaling. These compounds enhanced the insulin signaling pathway, improved lipid metabolism, and reduced oxidative stress by decreasing reactive oxygen species (ROS) production. Additionally, they were shown to alleviate inflammation by inhibiting the NF-kappa B pathway and downregulating pro-inflammatory cytokines and enzymes. Furthermore, these bioactive compounds were observed to mitigate endoplasmic reticulum (ER) stress by downregulating stress markers, thereby protecting beta cells from apoptosis and preserving their function. In summary, olive oil, particularly its bioactive constituents, has been demonstrated to enhance insulin sensitivity, protect beta cell function, and reduce inflammation and oxidative stress by modulating key genes involved in these processes. These findings underscore olive oil's therapeutic potential in managing T2DM. However, further research, including well-designed human clinical trials, is required to fully elucidate the role of olive oil in personalized nutrition strategies for the prevention and treatment of T2DM.
C1 [Munteanu, Camelia] Univ Agr Sci & Vet Med Cluj Napoca, Fac Agr, Dept Plant Culture, Cluj Napoca 400372, Romania.
   [Kotova, Polina; Schwartz, Betty] Hebrew Univ Jerusalem, Inst Biochem Food Sci & Nutr, Robert H Smith Fac Agr Food & Environm, Sch Nutr Sci, IL-9190500 Rehovot, Israel.
C3 University of Agricultural Sciences & Veterinary Medicine Cluj Napoca;
   Hebrew University of Jerusalem
RP Munteanu, C (corresponding author), Univ Agr Sci & Vet Med Cluj Napoca, Fac Agr, Dept Plant Culture, Cluj Napoca 400372, Romania.; Schwartz, B (corresponding author), Hebrew Univ Jerusalem, Inst Biochem Food Sci & Nutr, Robert H Smith Fac Agr Food & Environm, Sch Nutr Sci, IL-9190500 Rehovot, Israel.
EM camelia.munteanu@usamvcluj.ro; betty.schwartz@mail.huji.ac.il
RI Camelia, Munteanu/AAA-7209-2021
OI Camelia, Munteanu/0000-0001-9322-7033
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NR 357
TC 2
Z9 2
U1 8
U2 8
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD FEB
PY 2025
VL 17
IS 3
AR 570
DI 10.3390/nu17030570
PG 56
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA W5C9B
UT WOS:001418763300001
PM 39940428
OA gold
DA 2025-06-11
ER

PT J
AU Lipan, L
   Cano-Lamadrid, M
   Collado-González, J
   Wojdylo, A
   López-Lluch, D
   Moriana, A
   Carbonell-Barrachina, AA
AF Lipan, Leontina
   Cano-Lamadrid, Marina
   Collado-Gonzalez, Jacinta
   Wojdylo, Aneta
   Lopez-Lluch, David
   Moriana, Alfonso
   Carbonell-Barrachina, Angel A.
TI Correlation between water stress and phenolic compounds of
   hydroSOStainable almonds
SO JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
LA English
DT Article
DE Prunus dulcis; deficit irrigation; a* color coordinate;
   isorhamnetin-3-O-rutinoside; isorhamnetin-3-O-glucoside;
   kaempferol3-O-glucoside
ID QUALITY; CULTIVARS; FOOD
AB BACKGROUND: Water scarcity is currently affecting many areas of the world, reaching worrying levels in drought areas such as southern Spain. To cope with this issue, researchers in the agricultural sector have implemented deficit irrigation strategies intended to reduce water consumption by increasing fruit quality. Almond is among the most popular tree nuts worldwide and also the most nut cultivated in Spain. Almond consumption, together with other nuts, has been widely associated with improvements in cardiovascular health, metabolic syndrome and diabetes owing to their bioactive compounds such as polyphenols. Water deficit strategies generate hydroSOStainable almonds, raised under water stress conditions, with high content of bioactive compounds. The aim of this work was to study the relationship between water stress, color and polyphenols in hydroSOStainable almonds. For this, instrumental color, total phenolic content and phenolic compounds were measured and correlated using Pearson's correlation.
   RESULTS: The results showed a strong relationship between water stress, color and polyphenols of almonds, showing that increasing water stress in plants up to similar to 100 MPa x day values of stress integral increase the polyphenols in almonds, leading to a reddish color.
   CONCLUSION: Finally, this research demonstrated that implementing water-saving strategies help to improve the phenolic content and color of hydroSOStainable almonds and also that isorhamnetin-3-O-rutinoside, isorhamnetin-3-O-glucoside and kaempferol-3-O-glucoside could be important markers of hydroSOStainable almonds (cv. Vairo). Besides, hydroSOStainable almonds could be an important source of phenols, providing 25% of the estimated total polyphenolic daily intake. (c) 2020 Society of Chemical Industry
C1 [Lipan, Leontina; Cano-Lamadrid, Marina; Carbonell-Barrachina, Angel A.] Univ Miguel Hernandez Elche UMH, Res Grp Food Qual & Safety, Dept Agrofood Technol, CSA,Escuela Politecn Super Orihuela EPSO, Orihuela, Spain.
   [Collado-Gonzalez, Jacinta] CSIC, Res Grp Qual Safety & Bioact Plant Foods, Dept Food Sci & Technol, CEBAS, Univ Campus Espinardo, Murcia, Spain.
   [Wojdylo, Aneta] Wroclaw Univ Environm & Life Sci, Dept Fruit Vegetable & Plant Nutraceut Technol, Wroclaw, Poland.
   [Lopez-Lluch, David] UMH, EPSO, Dept Agroenvironm Econ, Orihuela, Spain.
   [Moriana, Alfonso] Univ Seville, Dept Ciencias Agroforest, ETSIA, Seville, Spain.
   [Moriana, Alfonso] IRNAS, US, Unidad Asociada CSIC Uso Sostenible Suelo Agua Ag, Seville, Spain.
C3 Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Centro de
   Edafologia y Biologia Aplicada del Segura (CEBAS); Wroclaw University of
   Environmental & Life Sciences; Universidad Miguel Hernandez de Elche;
   University of Sevilla; Consejo Superior de Investigaciones Cientificas
   (CSIC); CSIC - Instituto de Recursos Naturales y Agrobiologia de Sevilla
   (IRNAS); University of Sevilla
RP Carbonell-Barrachina, AA (corresponding author), Univ Miguel Hernandez Elche UMH, Res Grp Food Qual & Safety, Dept Agrofood Technol, CSA,Escuela Politecn Super Orihuela EPSO, Carretera Beniel,Km 3-2, Alicante 03312, Spain.
EM angel.carbonell@umh.es
RI Cano-Lamadrid, Marina/ABI-8156-2020; Collado González,
   Jacinta/A-9851-2015; Wojdyło, Aneta/B-3639-2017; Moriana,
   Alfonso/B-1272-2014; Lluch, David/H-7884-2015; Carbonell-Barrachina,
   Ángel/J-6592-2012; Lipan, Leontina/AAD-3760-2019
OI Carbonell-Barrachina, Angel A./0000-0002-7163-2975; Lipan,
   Leontina/0000-0002-2468-0560; Wojdylo, Aneta/0000-0002-0067-0691;
   Cano-Lamadrid, Marina/0000-0001-6679-7161
FU Spanish Government (Ministerio de Ciencia e Innovacion (MCI)); Agencia
   Estatal de Investigacion (AEI) [AGL2016-75794-C4-1-R,
   AGL2016-75794-C4-4-R]; Fondo Europeo de Desarrollo Regional (FEDER) 'Una
   manera de hacer Europa', (MCI/AEI/FEDER, UE); Formacion de Profesorado
   Universitario (FPU) grant from the Spanish Ministry of Education
   [FPU15/02158]
FX The study has been funded by the Spanish Government (Ministerio de
   Ciencia e Innovacion (MCI), Agencia Estatal de Investigacion (AEI),
   through a coordinated research project (hydroSOS) including the
   Universidad Miguel Hernandez de Elche (AGL2016-75794-C4-1-R, Productos
   hidroSOStenibles: identificacion de debilidades y fortalezas,
   optimizacion del procesado, creacion de marca propia, y estudio de su
   aceptacion en el mercado europeo, hydroSOS foods) and the Universidad de
   Sevilla (AGL2016-75794-C4-4-R); these projects have been also funded by
   Fondo Europeo de Desarrollo Regional (FEDER) 'Una manera de hacer
   Europa', (MCI/AEI/FEDER, UE). The author M. Cano-Lamadrid was funded by
   a Formacion de Profesorado Universitario (FPU) grant from the Spanish
   Ministry of Education (FPU15/02158).
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NR 27
TC 2
Z9 2
U1 0
U2 15
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-5142
EI 1097-0010
J9 J SCI FOOD AGR
JI J. Sci. Food Agric.
PD MAY
PY 2021
VL 101
IS 7
BP 3065
EP 3070
DI 10.1002/jsfa.10896
EA NOV 2020
PG 6
WC Agriculture, Multidisciplinary; Chemistry, Applied; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture; Chemistry; Food Science & Technology
GA RI2YC
UT WOS:000589833800001
PM 33135800
DA 2025-06-11
ER

PT J
AU Pedersen, BK
   Saltin, B
AF Pedersen, BK
   Saltin, B
TI Evidence for prescribing exercise as therapy in chronic disease
SO SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
LA English
DT Review
ID QUALITY-OF-LIFE; RANDOMIZED CONTROLLED-TRIAL; CHRONIC HEART-FAILURE;
   BONE-MINERAL DENSITY; CARDIOVASCULAR RISK-FACTORS; RESTING
   BLOOD-PRESSURE; OBSTRUCTIVE PULMONARY-DISEASE; DEPENDENT
   DIABETES-MELLITUS; HOME-BASED EXERCISE; HIGH-INTENSITY EXERCISE
AB Considerable knowledge has accumulated in recent decades concerning the significance of physical activity in the treatment of a number of diseases, including diseases that do not primarily manifest as disorders of the locomotive apparatus. In this review we present the evidence for prescribing exercise therapy in the treatment of metabolic syndrome-related disorders (insulin resistance, type 2 diabetes, dyslipidemia, hypertension, obesity), heart and pulmonary diseases (chronic obstructive pulmonary disease, coronary heart disease, chronic heart failure, intermittent claudication), muscle, bone and joint diseases (osteoarthritis, rheumatoid arthritis, osteoporosis, fibromyalgia, chronic fatigue syndrome) and cancer, depression, asthma and type 1 diabetes. For each disease, we review the effect of exercise therapy on disease pathogenesis, on symptoms specific to the diagnosis, on physical fitness or strength and on quality of life. The possible mechanisms of action are briefly examined and the principles for prescribing exercise therapy are discussed, focusing on the type and amount of exercise and possible contraindications.
C1 Univ Copenhagen, Ctr Inflammat & Metab, Dept Infect Dis, Copenhagen, Denmark.
   Univ Copenhagen, Copenhagen Muscle Res Ctr, Rigshosp, Fac Hlth Sci, Copenhagen, Denmark.
C3 University of Copenhagen; University of Copenhagen; Copenhagen
   University Hospital; Rigshospitalet
RP Rigshosp, Ctr Inflammat & Metab, Sect 7641, Dept Infect Dis, Blegdamsvej 9, DK-2100 Copenhagen, Denmark.
EM bkp@rh.dk
RI Pedersen, Bente/AGR-3217-2022
OI Pedersen, Bente Klarlund/0000-0001-6508-6288
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NR 737
TC 1604
Z9 1886
U1 20
U2 377
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0905-7188
EI 1600-0838
J9 SCAND J MED SCI SPOR
JI Scand. J. Med. Sci. Sports
PD FEB
PY 2006
VL 16
SU 1
BP 3
EP 63
DI 10.1111/j.1600-0838.2006.00520.x
PG 61
WC Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Sport Sciences
GA 008TM
UT WOS:000235063600001
PM 16451303
OA Bronze
DA 2025-06-11
ER

PT J
AU Peake, CG
   Odgers-Jewell, K
   de Sousa, CJ
   English, CJ
   Ingabire, A
   Mayr, HL
   Reidlinger, DP
AF Peake, Charlotte G.
   Odgers-Jewell, Kate
   de Sousa, Chantal J.
   English, Carolyn J.
   Ingabire, Ale
   Mayr, Hannah L.
   Reidlinger, Dianne P.
TI Association between dietary inflammatory or oxidative stress indices and
   biomarkers in cardiometabolic and related conditions: a systematic
   literature review
SO BRITISH JOURNAL OF NUTRITION
LA English
DT Review; Early Access
DE CVD; Dietary patterns; Dietary inflammatory index; Inflammation;
   Oxidative stress; Systematic review
ID C-REACTIVE PROTEIN; HEMODIALYSIS-PATIENTS; DISEASES; ADULTS; SCORE; RISK
AB Inflammation and oxidative stress contribute to the progression of chronic diseases, and the volume of research in this area is rapidly expanding. Various dietary indices have been developed to determine the overall inflammatory or oxidative stress potential of a diet; however, few have been validated in cardiometabolic disease populations. This review aimed to explore the association between dietary indices and biomarkers of inflammation and oxidative stress in adults with cardiometabolic conditions. Four databases were systematically searched for literature in any language (Embase, CINAHL, CENTRAL and MEDLINE) with 12,286 deduplicated records identified. Seventeen studies of adults with metabolic syndrome, cardiovascular disease, type 2 diabetes, non-alcoholic fatty liver disease or chronic kidney disease were included. Fourteen studies were observational studies, one study was a clinical trial, and one was a randomised controlled trial. Four dietary indices were reported on with most studies (n 11) reporting on the dietary inflammatory index. The most reported biomarker was C-reactive protein. The findings were narratively synthesised. Results were inconclusive due to the heterogeneity of dietary indices and their use, disease states and biomarkers reported. Only one study reporting on the dietary inflammatory index assessed all 45 parameters. Observational studies, particularly retrospective designs (n 7), are subject to recall and selection biases, potentially presenting overestimated results. Further research is required to determine the relationship between dietary indices and biomarkers of inflammation and oxidative stress in cardiometabolic disease populations. Future research should be prospective, utilise rigorous research methods, assess the full range of index parameters, and examine biomarkers the tool was developed for.
C1 [Peake, Charlotte G.; Odgers-Jewell, Kate; de Sousa, Chantal J.; English, Carolyn J.; Ingabire, Ale; Mayr, Hannah L.; Reidlinger, Dianne P.] Bond Univ, Fac Hlth Sci & Med, Gold Coast, Qld 4226, Australia.
   [Mayr, Hannah L.] Princess Alexandra Hosp, Dept Nutr & Dietet, Brisbane, Qld 4102, Australia.
   [Mayr, Hannah L.] Univ Queensland, Fac Hlth Med & Behav Sci, Greater Brisbane Clin Sch, Brisbane, Qld 4072, Australia.
C3 Bond University; Princess Alexandra Hospital; University of Queensland
RP Odgers-Jewell, K (corresponding author), Bond Univ, Fac Hlth Sci & Med, Gold Coast, Qld 4226, Australia.
EM kodgersj@bond.edu.au
RI Reidlinger, Dianne/D-3160-2017; Odgers-Jewell, Kate/AAA-8667-2019;
   English, Carolyn/IVH-1441-2023
OI ENGLISH, CAROLYN/0000-0002-5539-6239
FU Health Sciences and Medicine at Bond University
FX The authors acknowledge Sarah Bateup, Faculty Librarian, Health Sciences
   and Medicine at Bond University for her assistance with the search
   strategy.
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NR 60
TC 0
Z9 0
U1 0
U2 0
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1145
EI 1475-2662
J9 BRIT J NUTR
JI Br. J. Nutr.
PD 2025 MAR 31
PY 2025
DI 10.1017/S0007114525000686
EA MAR 2025
PG 17
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 2OT6N
UT WOS:001487714200001
PM 40159854
DA 2025-06-11
ER

PT J
AU Langley, MR
   Yoon, H
   Kim, HN
   Choi, CI
   Simon, W
   Kleppe, L
   Lanza, IR
   LeBrasseur, NK
   Matveyenko, A
   Scarisbrick, IA
AF Langley, Monica R.
   Yoon, Hyesook
   Kim, Ha Neui
   Choi, Chan-Il
   Simon, Whitney
   Kleppe, Laurel
   Lanza, Ian R.
   LeBrasseur, Nathan K.
   Matveyenko, Aleksey
   Scarisbrick, Isobel A.
TI High fat diet consumption results in mitochondrial dysfunction,
   oxidative stress, and oligodendrocyte loss in the central nervous system
SO BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
LA English
DT Article
DE High fat diet; Myelin; Oligodendrocyte; Mitochondria; Apoptosis
ID ENDOPLASMIC-RETICULUM STRESS; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS;
   UNFOLDED PROTEIN RESPONSE; MULTIPLE-SCLEROSIS; CARDIOVASCULAR-DISEASE;
   SIGNALING PATHWAY; CORPUS-CALLOSUM; UP-REGULATION; EXPRESSION;
   ACTIVATION
AB Metabolic syndrome is a key risk factor and co-morbidity in multiple sclerosis (MS) and other neurological conditions, such that a better understanding of how a high fat diet contributes to oligodendrocyte loss and the capacity for myelin regeneration has the potential to highlight new treatment targets. Results demonstrate that modeling metabolic dysfunction in mice with chronic high fat diet (HFD) consumption promotes loss of oligodendrocyte progenitors across the brain and spinal cord. A number of transcriptomic and metabolomic changes in ER stress, mitochondrial dysfunction, and oxidative stress pathways in HFD-fed mouse spinal cords were also identified. Moreover, deficits in TCA cycle intermediates and mitochondrial respiration were observed in the chronic HFD spinal cord tissue. Oligodendrocytes are known to be particularly vulnerable to oxidative damage, and we observed increased markers of oxidative stress in both the brain and spinal cord of HFD-fed mice. We additionally identified that increased apoptotic cell death signaling is underway in oligodendrocytes from mice chronically fed a HFD. When cultured under high saturated fat conditions, oligodendrocytes decreased both mitochondrial function and differentiation. Overall, our findings show that HFD-related changes in metabolic regulators, decreased mitochondrial function, and oxidative stress contribute to a loss of myelinating cells. These studies identify FWD consumption as a key modifiable lifestyle factor for improved myelin integrity in the adult central nervous system and in addition new tractable metabolic targets for myelin protection and repair strategies.
C1 [Langley, Monica R.; Yoon, Hyesook; Kim, Ha Neui; Choi, Chan-Il; Simon, Whitney; Kleppe, Laurel; LeBrasseur, Nathan K.; Scarisbrick, Isobel A.] Mayo Clin, Rehabil Med Res Ctr, Dept Phys Med & Rehabil, Rochester, MN 55905 USA.
   [Yoon, Hyesook; Lanza, Ian R.; LeBrasseur, Nathan K.; Matveyenko, Aleksey; Scarisbrick, Isobel A.] Mayo Clin, Dept Physiol & Biomed Engn, Rochester, MN 55905 USA.
   [Lanza, Ian R.; Matveyenko, Aleksey] Mayo Clin, Dept Endocrinol, Rochester, MN 55905 USA.
C3 Mayo Clinic; Mayo Clinic; Mayo Clinic
RP Scarisbrick, IA (corresponding author), Mayo Clin, Rehabil Med Res Ctr, Phys Med & Rehabil, Neurobiol Dis Program, 642B Guggenheim Bldg,200 First St SW, Rochester, MN 55905 USA.
EM scarisbrick.isobel@mayo.edu
RI LeBrasseur, Nathan/HGD-6434-2022
OI Lanza, Ian/0000-0002-9858-3384; Langley, Monica/0000-0002-3146-1067;
   Kim, Haneui/0000-0002-5651-4727
FU Mayo Clinic Center for Multiple Sclerosis and Autoimmune Neurology
   (CMSAN); Eugene and Marcia Applebaum Foundation; Mayo Clinic Center for
   Biomedical Discovery (CBD); Mayo Clinic Metabolomics Core [U24DK100469,
   UL1TR000135]; National Multiple Sclerosis Society [R01NS052741, RG4958];
   Craig H. Neilsen Foundation; Minnesota State Spinal Cord Injury and
   Traumatic Brain Injury Research Program
FX The work was supported by Mayo Clinic Center for Multiple Sclerosis and
   Autoimmune Neurology (CMSAN), the Eugene and Marcia Applebaum
   Foundation, the Mayo Clinic Center for Biomedical Discovery (CBD) and
   the Mayo Clinic Metabolomics Core (U24DK100469 and UL1TR000135).
   Portions of this work were also supported by R01NS052741, RG4958 from
   the National Multiple Sclerosis Society, a grant from the Craig H.
   Neilsen Foundation, and the Minnesota State Spinal Cord Injury and
   Traumatic Brain Injury Research Program.
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NR 104
TC 56
Z9 62
U1 1
U2 18
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29a, 1043 NX AMSTERDAM, NETHERLANDS
SN 0925-4439
EI 1879-260X
J9 BBA-MOL BASIS DIS
JI Biochim. Biophys. Acta-Mol. Basis Dis.
PD MAR 1
PY 2020
VL 1866
IS 3
AR 165630
DI 10.1016/j.bbadis.2019.165630
PG 18
WC Biochemistry & Molecular Biology; Biophysics; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Cell Biology
GA KH2UY
UT WOS:000510504400006
PM 31816440
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Wang, T
   Xu, ZH
AF Wang, Tong
   Xu, Zi-hui
TI Natural Compounds with Aldose Reductase (AR) Inhibition: A Class of
   Medicative Agents for Fatty Liver Disease
SO COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING
LA English
DT Review
DE Fatty liver disease; aldose reductase; natural AR inhibitors;
   inflammation; oxidative stress; lipid metabolism
ID ATTENUATES NONALCOHOLIC STEATOHEPATITIS; ACTIVATED-RECEPTOR-ALPHA;
   OXIDATIVE STRESS; ELLAGIC ACID; ALCOHOLIC STEATOHEPATITIS;
   LIPID-ACCUMULATION; CHLOROGENIC ACID; INDUCED NAFLD; FERULIC ACID;
   IN-VITRO
AB Fatty liver disease (FLD), which includes both non-alcoholic fatty liver disease (NAFLD) and alcoholic fatty liver disease (ALD), is a worldwide health concern. The etiology of ALD is long-term alcohol consumption, while NAFLD is defined as an abnormal amount of lipid present in liver cells, which is not caused by alcohol intake and has recently been identified as a hepatic manifestation of metabolic syndrome (such as type 2 diabetes, obesity, hypertension, and obesity). Inflammation, oxidative stress, and lipid metabolic dysregulation are all known to play a role in FLD progression. Alternative and natural therapies are desperately needed to treat this disease since existing pharmaceuticals are mostly ineffective. The aldose reductase (AR)/polyol pathway has recently been shown to play a role in developing FLD by contributing to inflammation, oxidative stress, apoptosis, and fat accumulation. Herein, we review the effects of plant-derived compounds capable of inhibiting AR in FLD models. Natural AR inhibitors have been found to improve FLD in part by suppressing inflammation, oxidative stress, and steatosis via the regulation of several critical pathways, including the peroxisome proliferator-activated receptor (PPAR) pathway, cytochrome P450 2E1 (CYP2E1) pathway, AMP-activated protein kinase (AMPK) pathway, etc. This review revealed that natural compounds with AR inhibitory effects are a promising class of therapeutic agents for FLD.
C1 [Wang, Tong; Xu, Zi-hui] Army Med Univ, Xinqiao Hosp, Dept Integrat Med, Chongqing, Peoples R China.
C3 Army Medical University
RP Wang, T (corresponding author), Army Med Univ, Xinqiao Hosp, Dept Integrat Med, Chongqing, Peoples R China.
EM wangtong_1997@163.com
RI Wang, Tong/LRU-1497-2024
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NR 160
TC 2
Z9 2
U1 4
U2 9
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1386-2073
EI 1875-5402
J9 COMB CHEM HIGH T SCR
JI Comb. Chem. High Throughput Screen
PY 2023
VL 26
IS 11
BP 1929
EP 1944
DI 10.2174/1386207326666230119101011
PG 16
WC Biochemical Research Methods; Chemistry, Applied; Pharmacology &
   Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry; Pharmacology & Pharmacy
GA M5IW7
UT WOS:001030562300001
PM 36655533
DA 2025-06-11
ER

PT J
AU Rungapamestry, V
   McMonagle, J
   Reynolds, C
   Rucklidge, G
   Reid, M
   Duncan, G
   Ross, K
   Horgan, G
   Toomey, S
   Moloney, AP
   de Roos, B
   Roche, HM
AF Rungapamestry, Vanessa
   McMonagle, Jolene
   Reynolds, Clare
   Rucklidge, Garry
   Reid, Martin
   Duncan, Gary
   Ross, Karen
   Horgan, Graham
   Toomey, Sinead
   Moloney, Aidan P.
   de Roos, Baukje
   Roche, Helen M.
TI Inter-organ proteomic analysis reveals insights into the molecular
   mechanisms underlying the anti-diabetic effects of cis-9,
   trans-11-conjugated linoleic acid in ob/ob mice
SO PROTEOMICS
LA English
DT Article
DE Cellular stress; Cis-9 trans-11 CLA; Inflammation; Insulin sensitivity;
   Systems biology
ID ENDOPLASMIC-RETICULUM STRESS; HIGH-FAT DIET; WHITE ADIPOSE-TISSUE;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; SKELETAL-MUSCLE; BEEF-PRODUCTION;
   PHOSPHATASE 2A; KNOCKOUT MICE; INFLAMMATION
AB cis-9, trans-11-Conjugated linoleic acid (c9 t11 CLA) exerts anti-diabetic effects by improving systemic insulin sensitivity and inflammation. Levels of CLA in beef can be increased by feeding cattle on pasture. This study aimed to explore the efficacy of a CLA-rich diet (0.6%?w/w c9 t11 CLA), presented as beef enriched with CLA or beef supplemented with synthetic CLA (c9 t11 CLA), for 28 days on molecular biomarkers of the metabolic syndrome, and adipose, hepatic, and skeletal muscle proteome in male ob/ob mice. Despite equal weight gain, CLA-fed mice had lower plasma glucose, insulin, non-esterified fatty acid, triacylglycerol and interleukin-6, and higher adiponectin concentrations than controls. c9 t11 CLA induced differential regulation of redox status across all tissues, and decreased hepatic and muscle endoplasmic reticulum stress. CLA also modulated mechanistic links between the actin cytoskeleton, insulin signalling, glucose transport and inflammation in the adipose tissue. In the liver and muscle, c9 t11 CLA improved metabolic flexibility through co-ordination between carbohydrate and energy metabolism. c9 t11 CLA may ameliorate systemic insulin sensitivity in obesity-induced diabetes by altering cellular stress and redox status, and modulating nutrient handling in key insulin-sensitive tissues through complex biochemical interplay among representative proteomic signatures.
C1 [Rungapamestry, Vanessa; Rucklidge, Garry; Reid, Martin; Duncan, Gary; Ross, Karen; de Roos, Baukje] Univ Aberdeen, Rowett Inst Nutr & Hlth, Aberdeen, Scotland.
   [Rungapamestry, Vanessa; McMonagle, Jolene; Reynolds, Clare; Toomey, Sinead; Roche, Helen M.] Univ Coll Dublin, Sch Publ Hlth & Populat Sci, UCD Conway Inst, Nutrigenom Res Grp, Dublin 4, Ireland.
   [Rungapamestry, Vanessa; McMonagle, Jolene; Reynolds, Clare; Toomey, Sinead; Roche, Helen M.] Univ Coll Dublin, Sch Publ Hlth & Populat Sci, UCD Inst Food & Hlth, Dublin 4, Ireland.
   [Horgan, Graham] Biomath & Stat Scotland, Rowett Inst Nutr & Hlth, Aberdeen, Scotland.
   [Moloney, Aidan P.] Teagasc, Anim & Grassland Res & Innovat Ctr, Dunsany, Meath, Ireland.
C3 University of Aberdeen; University College Dublin; University College
   Dublin; University of Aberdeen; James Hutton Institute; Teagasc
RP Roche, HM (corresponding author), Univ Coll Dublin, UCD Sch Publ Hlth, UCD Conway Inst, Nutrigenom Res Grp, Dublin 4, Ireland.
EM helen.roche@ucd.ie
RI Horgan, Graham/J-3738-2013
OI Horgan, Graham/0000-0002-6048-1374; Roche, Helen/0000-0002-0628-3318; de
   Roos, Baukje/0000-0002-2750-3914; Reynolds, Clare/0000-0001-5782-6303;
   Toomey, Sinead/0000-0002-1365-8173
FU Irish Department of Agriculture and Food, Food Institutional Research
   Measure [FIRM 06RDTCD488]; FIRM; Teagasc; Scottish Government Rural and
   Environment Research and Analysis Directorate; SFI_PI Programme
   [06/IM.1/B105]
FX Vanessa Rungapamestry was responsible for the processing of tissue
   samples for proteomic analysis, analysis and interpretation of the
   inter-organ proteomic data, and editing of the manuscript. J.M.M. was
   responsible for the conduct of the animal experiment and generation of
   physiological data in plasma and adipose tissue. H.M.R., A.P.M., B.d.R.
   conceptualized the study. This work was funded by the Irish Department
   of Agriculture and Food, Food Institutional Research Measure (FIRM
   06RDTCD488). V.R. and S.T. were supported by FIRM; J.M.M. was the
   recipient of a Walsh Fellowship from Teagasc; V.R., B.d.R., G.R., M.R.,
   G.D., K.R., and G.H. were supported by the Scottish Government Rural and
   Environment Research and Analysis Directorate; and H.M.R. was supported
   by SFI_PI Programme (06/IM.1/B105).
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NR 44
TC 19
Z9 20
U1 0
U2 19
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1615-9853
J9 PROTEOMICS
JI Proteomics
PD FEB
PY 2012
VL 12
IS 3
BP 461
EP 476
DI 10.1002/pmic.201100312
PG 16
WC Biochemical Research Methods; Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 883HB
UT WOS:000299623700016
PM 22144173
DA 2025-06-11
ER

PT J
AU Cavalheiro, EKFF
   da Silva, LE
   Oliveira, MP
   Silva, MG
   Damiani, AP
   Ribeiro, CD
   Magenis, ML
   Cucker, L
   Michels, M
   Joaquim, L
   Machado, RS
   Vilela, TC
   Bitencourt, RM
   Andrade, VM
   Dal-Pizzol, F
   Petronilho, F
   Tuon, T
   Rezin, GT
AF Cavalheiro, Eulla Keimili Fernandes Ferreira
   da Silva, Larissa Espindola
   Oliveira, Mariana Pacheco
   Silva, Marina Goulart
   Damiani, Adriani Paganini
   Ribeiro, Catharina de Bem
   Magenis, Marina Lummertz
   Cucker, Luana
   Michels, Monique
   Joaquim, Larissa
   Machado, Richard Simon
   Vilela, Thais Cereser
   Bitencourt, Rafael M.
   Andrade, Vanessa M.
   Dal-Pizzol, Felipe
   Petronilho, Fabricia
   Tuon, Talita
   Rezin, Gislaine Tezza
TI Effects of obesity on neuroinflammatory and neurochemical parameters in
   an animal model of reserpine-induced Parkinson's disease
SO BEHAVIOURAL BRAIN RESEARCH
LA English
DT Article
DE Obesity; Parkinson's disease; Neuroinflammation; Oxidative stress
ID HIGH-FAT DIET; OXIDATIVE STRESS; ADIPOSE-TISSUE; INSULIN-RESISTANCE;
   MITOCHONDRIAL DYSFUNCTION; METABOLIC SYNDROME; SUBSTANTIA-NIGRA;
   INFLAMMATION; DOPAMINE; DAMAGE
AB Obesity is associated with low-grade chronic inflammation and oxidative stress, affecting the brain's reward system by decreasing dopaminergic neurotransmission. It is known that dopaminergic neurotransmission is also reduced in Parkinson's disease (PD), and high adiposity is considered a risk factor for the development of several neurodegenerative diseases, including PD. This study aimed to assess the effects of obesity on neuroinflammatory and neurochemical parameters in an animal model of reserpine-induced PD. The obese group showed increased inflammation and oxidative damage as well as inhibition of mitochondrial respiratory chain complexes I and II and DNA damage in the evaluated structures. The PD group did not show inflammation or mitochondrial dysfunction but exhibited oxidative damage in the hippocampus. The combination group (obesity + PD) showed reduced inflammation and oxidative stress and increased activity of complexes I and II of the mitochondrial respiratory chain in most of the analyzed structures. On the other hand, obesity + PD caused oxidative damage to proteins in the liver, prefrontal cortex, striatum, and cerebral cortex and oxidative stress in the hypothalamus, resulting in reduced catalase activity. Furthermore, the combination group showed DNA damage in blood, liver, and cerebral cortex. In conclusion, it was observed that the association of obesity and PD did not increase inflammation, oxidative stress, or mitochondrial dysfunction in most of the evaluated structures but increased oxidative damage and induced mechanisms that led to DNA damage in peripheral tissues and brain structures.
C1 [Cavalheiro, Eulla Keimili Fernandes Ferreira; da Silva, Larissa Espindola; Oliveira, Mariana Pacheco; Joaquim, Larissa; Machado, Richard Simon; Vilela, Thais Cereser; Petronilho, Fabricia; Tuon, Talita; Rezin, Gislaine Tezza] Univ Southern Santa Catarina, Postgrad Program Hlth Sci, Lab Neurobiol Inflammatory & Metab Proc, Tubarao, SC, Brazil.
   [Silva, Marina Goulart; Bitencourt, Rafael M.] Univ Southern Santa Catarina, Postgrad Program Hlth Sci, Lab Behav Neurosci, Tubarao, SC, Brazil.
   [Damiani, Adriani Paganini; Ribeiro, Catharina de Bem; Magenis, Marina Lummertz; Andrade, Vanessa M.] Univ Extremo Sul Catarinense, Univ Extremo Catarinense, Lab Biol Celular & Mol, Ave Univ 1105, Criciuma, SC, Brazil.
   [Cucker, Luana; Michels, Monique; Dal-Pizzol, Felipe] Univ Southern Santa Catarina, Grad Program Hlth Sci, Lab Expt Pathophysiol, Criciuma, SC, Brazil.
   [Rezin, Gislaine Tezza] Universityof Southern Santa Catarina, Ave Jose Acacio Moreira 787, BR-88704900 Tubarao, SC, Brazil.
C3 Universidade do Sul de Santa Catarina; Universidade do Sul de Santa
   Catarina; Universidade do Extremo Sul Catarinense; Universidade do Sul
   de Santa Catarina
RP Rezin, GT (corresponding author), Universityof Southern Santa Catarina, Ave Jose Acacio Moreira 787, BR-88704900 Tubarao, SC, Brazil.
EM gitezza@hotmail.com
RI Petronilho, Fabricia/D-8822-2013; Dal-Pizzol, Felipe/F-2756-2015; da
   Silva, Marina/AAC-1768-2019; MICHELS, MONIQUE/U-3967-2019; Andrade,
   Vanessa/F-9623-2012; Damiani, Adriani/N-8007-2018; Joaquim,
   Larissa/AAP-3309-2021; Bitencourt, Rafael/I-9302-2017
OI Petronilho, Fabricia/0000-0003-3240-2808; Joaquim,
   Larissa/0000-0003-1702-7552; Goulart da Silva,
   Marina/0000-0001-5354-7948; Oliveira, Mariana
   Pacheco/0000-0002-2046-2101; Bitencourt, Rafael/0000-0003-4694-3808;
   Vilela, Thais Cereser/0000-0002-2986-1715; da Silva,
   Larissa/0000-0001-7514-6272
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NR 148
TC 5
Z9 6
U1 0
U2 5
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0166-4328
EI 1872-7549
J9 BEHAV BRAIN RES
JI Behav. Brain Res.
PD SEP 26
PY 2022
VL 434
AR 114019
DI 10.1016/j.bbr.2022.114019
EA AUG 2022
PG 13
WC Behavioral Sciences; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Behavioral Sciences; Neurosciences & Neurology
GA 5A9VR
UT WOS:000863227100003
PM 35872330
DA 2025-06-11
ER

PT J
AU Raza, H
   John, A
   Howarth, FC
AF Raza, Haider
   John, Annie
   Howarth, Frank Christopher
TI Increased Oxidative Stress and Mitochondrial Dysfunction in Zucker
   Diabetic Rat Liver and Brain
SO CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
LA English
DT Article
DE Zucker diabetic rats; Liver; Brain; Oxidative stress; Mitochondrial
   dysfunction
ID INSULIN-RESISTANCE; ALTERED MECHANISMS; REDOX HOMEOSTASIS; CHANGING
   PATTERN; NADPH OXIDASE; OBESITY; CARDIOMYOPATHY; SENSITIVITY;
   SUPEROXIDE; METABOLISM
AB Background/Aims: The Zucker diabetic fatty (ZDF, FA/FA) rat is a genetic model of type 2 diabetes, characterized by insulin resistance with progressive metabolic syndrome. We have previously demonstrated mitochondrial dysfunction and oxidative stress in the heart, kidneys and pancreas of ZDF rats. However, the precise molecular mechanism of disease progression is not clear. Our aim in the present study was to investigate oxidative stress and mitochondrial dysfunction in the liver and brain of ZDF rats. Methods: In this study, we have measured mitochondrial oxidative stress, bioenergetics and redox homeostasis in the liver and brain of ZDF rats. Results: Our results showed increased reactive oxygen species (ROS) production in the ZDF rat brain compared to the liver, while nitric oxide (NO) production was markedly increased both in the brain and liver. High levels of lipid and protein peroxidation were also observed in these tissues. Glutathione metabolism and mitochondrial respiratory functions were adversely affected in ZDF rats when compared to Zucker lean (ZL, +/FA) control rats. Reduced ATP synthesis was also observed in the liver and brain of ZDF rats. Western blot analysis confirmed altered expression of cytochrome P450 2E1, iNOS, p-JNK, and I kappa B-alpha confirming an increase in oxidative and metabolic stress in ZDF rat tissues. Conclusions: Our data shows that, like other tissues, ZDF rat liver and brain develop complications associated with redox homeostasis and mitochondrial dysfunction. These results, thus, might have implications in understanding the etiology and pathophysiology of diabesity which in turn, would help in managing the disease associated complications. Copyright (C) 2015 S. Karger AG, Basel
C1 [Raza, Haider; John, Annie] UAE Univ, Coll Med & Hlth Sci, Dept Biochem, Al Ain, U Arab Emirates.
   [Howarth, Frank Christopher] UAE Univ, Coll Med & Hlth Sci, Dept Physiol, Al Ain, U Arab Emirates.
C3 United Arab Emirates University; United Arab Emirates University
RP Raza, H (corresponding author), UAE Univ, Coll Med & Hlth Sci, Dept Biochem, POB 17666, Al Ain, U Arab Emirates.
EM h.raza@uaeu.ac.ae
OI Raza, Haider/0000-0001-9680-5388
FU Sheikh Hamdan Bin Rashid Al-Maktoum Award for Medical Sciences; Terry
   Fox Cancer Research Fund; Research Committee, College of Medicine and
   Health Sciences Research Committee, UAE University
FX We acknowledge the financial research supports from Sheikh Hamdan Bin
   Rashid Al-Maktoum Award for Medical Sciences, Terry Fox Cancer Research
   Fund and a grant from Research Committee, College of Medicine and Health
   Sciences Research Committee, UAE University.
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NR 34
TC 101
Z9 109
U1 2
U2 23
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1015-8987
EI 1421-9778
J9 CELL PHYSIOL BIOCHEM
JI Cell. Physiol. Biochem.
PY 2015
VL 35
IS 3
BP 1241
EP 1251
DI 10.1159/000373947
PG 11
WC Cell Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Physiology
GA CD9FB
UT WOS:000351402100034
PM 25766534
OA gold
DA 2025-06-11
ER

PT J
AU Martin, H
   Uring-Lambert, B
   Adrian, M
   Lahlou, A
   Bonet, A
   Demougeot, C
   Devaux, S
   Laurant, P
   Richert, L
   Berthelot, A
AF Martin, Helene
   Uring-Lambert, Beatrice
   Adrian, Markus
   Lahlou, Abdeslam
   Bonet, Alexandre
   Demougeot, Celine
   Devaux, Sylvie
   Laurant, Pascal
   Richert, Lysiane
   Berthelot, Alain
TI Effects of long-term dietary intake of magnesium on oxidative stress,
   apoptosis and ageing in rat liver
SO MAGNESIUM RESEARCH
LA English
DT Article; Proceedings Paper
CT European Meeting on Magnesium (EuroMag)
CY MAY 15-17, 2008
CL Paris, FRANCE
DE magnesium; long-term; chronic; rat liver; oxidative stress; apoptosis;
   telomere; ageing
ID ENDOTHELIAL-CELLS; CULTURED-HEPATOCYTES; ANTIOXIDANT STATUS; METABOLIC
   SYNDROME; OXIDANT STRESS; BLOOD-PRESSURE; CDNA ARRAY; DEFICIENCY;
   POPULATION; HYPOMAGNESEMIA
AB In the present study, we investigated the effect of long-term dietary Mg intake on the rate of oxidative stress, apoptosis and ageing in rat livers. To address this issue, rats were fed diets containing either a moderately deficient (0.15 g Mg/kg diet), a standard (0.8 g Mg/kg diet) or a high (3.2 g Mg/kg diet) Mg dose for two years. It is noteworthy that a higher percentage of animal mortality was observed in the lowest Mg diet, as compared to the other groups. Oxidative stress and antioxidant status were evaluated by measuring different enzyme activities, among which glutathione peroxidase activity was significantly reduced when Mg content was decreased in the diet. Moreover, we obtained an activation of caspase-3 and a higher lipid peroxidation in the Mg-deficient group, as compared to the Mg standard group, while no changes in Mg-supplemented group were observed, in accordance with our previously published data in primary cultures of rat hepatocytes (Martin et al., J Nutr 2003). Telomere shortening was measured in rat livers, as a marker of ageing. We found that telomere length was decreased in old animals, as compared to young animals confirming that telomere shortening correlated well with ageing events. Moreover, in old animals, we obtained a decrease of telomere length in the Mg-deficient group, as compared to the other groups. Taken together, our results show that a long-term chronic Mg deficiency led to oxidative stress, apoptosis and an acceleration of ageing in rat livers.
C1 [Martin, Helene; Bonet, Alexandre; Richert, Lysiane] UFR Sci Med & Pharmaceut, EA 2SBP, Lab Toxicol Cellulaire, F-25030 Besancon, France.
   [Uring-Lambert, Beatrice; Lahlou, Abdeslam] Hop Univ, Immunol Lab, Strasbourg, France.
   [Adrian, Markus; Demougeot, Celine; Devaux, Sylvie; Laurant, Pascal; Berthelot, Alain] UFR Sci Med & Pharmaceut, EA 2SBP, Physiol Lab, F-25030 Besancon, France.
C3 CHU Strasbourg
RP Martin, H (corresponding author), UFR Sci Med & Pharmaceut, EA 2SBP, Lab Toxicol Cellulaire, Pl St Jacques, F-25030 Besancon, France.
EM helene.martin@univ-fcomte.fr
RI MARTIN, Hélène/E-2291-2018
OI Demougeot, Celine/0000-0003-0639-9756; Bonet,
   Alexandre/0000-0003-2226-793X; DEVAUX, Sylvie/0000-0003-4206-7580;
   MARTIN, helene/0000-0001-8318-3858
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NR 40
TC 41
Z9 47
U1 0
U2 4
PU JOHN LIBBEY EUROTEXT LTD
PI MONTROUGE
PA 127 AVE DE LA REPUBLIQUE, 92120 MONTROUGE, FRANCE
SN 0953-1424
J9 MAGNESIUM RES
JI Magnes. Res.
PD JUN
PY 2008
VL 21
IS 2
BP 124
EP 130
PG 7
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 326NH
UT WOS:000257665700008
PM 18705541
DA 2025-06-11
ER

PT J
AU Vata, D
   Tarcau, BM
   Popescu, IA
   Halip, IA
   Patrascu, AI
   Solovastru, DFG
   Mocanu, M
   Chiriac, PC
   Solovastru, LG
AF Vata, Dan
   Tarcau, Bogdan Marian
   Popescu, Ioana Adriana
   Halip, Ioana Alina
   Patrascu, Adriana Ionela
   Solovastru, Dragos-Florin Gheuca
   Mocanu, Madalina
   Chiriac, Petronela Cristina
   Gheuca Solovastru, Laura
TI Update on Obesity in Psoriasis Patients
SO LIFE-BASEL
LA English
DT Review
DE psoriasis; obesity; adipokines; autoimmune; microbiome
ID GUT MICROBIOTA; METABOLIC SYNDROME; SKIN INFLAMMATION; RISK-FACTORS;
   ADIPOKINES; METHOTREXATE; METAANALYSIS; ADIPONECTIN; ARTHRITIS; THERAPY
AB Psoriasis is a chronic inflammatory skin condition, with genetic, epigenetic, environmental, and lifestyle factors contributing to its onset and recurrence. Severe psoriasis has a great impact on quality of life, which is similar to that of insulin-dependent diabetes, depression, and ischemic heart disease, but with a lower mortality. There is an overlap between the rising incidences of autoimmune diseases and obesity. In recent years, research has shown that there is an association between psoriasis and obesity. Psoriasis is linked to obesity in a two-way manner, as each can precipitate the development of the other. Several adipose tissue-secreted adipokines were shown to be elevated in obese psoriasis patients, exhibiting similar mechanisms of action to those underlying the pathogenesis of psoriasis. Excess body weight can influence not only the treatment response in psoriasis, but also the adverse events, leading to decreased patient compliance. Specific human microbiome patterns have been identified for obesity and psoriasis and could represent a future therapeutic target in selected individuals.
C1 [Vata, Dan; Tarcau, Bogdan Marian; Popescu, Ioana Adriana; Halip, Ioana Alina; Patrascu, Adriana Ionela; Mocanu, Madalina; Gheuca Solovastru, Laura] Grigore T Popa Univ Med & Pharm, Dept Dermatol, Iasi 700115, Romania.
   [Vata, Dan; Tarcau, Bogdan Marian; Popescu, Ioana Adriana; Halip, Ioana Alina; Patrascu, Adriana Ionela; Mocanu, Madalina; Gheuca Solovastru, Laura] St Spiridon Cty Emergency Clin Hosp, Dermatol Clin, Iasi 700111, Romania.
   [Solovastru, Dragos-Florin Gheuca] Grigore T Popa Univ Med & Pharm, Iasi 700115, Romania.
   [Chiriac, Petronela Cristina] St Spiridon Cty Emergency Clin Hosp, Iasi 700111, Romania.
C3 Grigore T Popa University of Medicine & Pharmacy; Grigore T Popa
   University of Medicine & Pharmacy
RP Tarcau, BM; Popescu, IA (corresponding author), Grigore T Popa Univ Med & Pharm, Dept Dermatol, Iasi 700115, Romania.; Tarcau, BM; Popescu, IA (corresponding author), St Spiridon Cty Emergency Clin Hosp, Dermatol Clin, Iasi 700111, Romania.
EM dan.vata@umfiasi.ro; bogdan-marian.tarcau@d.umfiasi.ro;
   ioana-adriana.popescu@umfiasi.ro; ioana-alina.grajdeanu@umfiasi.ro;
   adriana.patrascu@umfiasi.ro; mg-eng-31249@student.umfiasi.ro;
   cristinachiriac73@gmail.com; solovastru.gheuca@umfiasi.ro
RI Madalina, MOCANU/R-2539-2019; Halip, Ioana'Alina/MTF-2337-2025; Tarcau,
   Bogdan/KHD-9333-2024; Solovastru, Laura/MTF-6124-2025; Vâță,
   Dan/AAE-1128-2020; Popescu, Ioana/AAA-3656-2020; CHIRIAC, Petronela
   Cristina/JWP-1547-2024
OI Halip, Ioana-Alina/0009-0005-2138-8176; Vata, Dan/0000-0002-2755-6004;
   CHIRIAC, Petronela Cristina/0009-0008-9528-9113
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NR 91
TC 15
Z9 15
U1 6
U2 22
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2075-1729
J9 LIFE-BASEL
JI Life-Basel
PD OCT
PY 2023
VL 13
IS 10
AR 1947
DI 10.3390/life13101947
PG 14
WC Biology; Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics; Microbiology
GA W2FE4
UT WOS:001089832500001
PM 37895330
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Chait, YA
   Mottawea, W
   Tompkins, TA
   Hammami, R
AF Chait, Yasmina Ait
   Mottawea, Walid
   Tompkins, Thomas A.
   Hammami, Riadh
TI Nutritional and therapeutic approaches for protecting human gut
   microbiota from psychotropic treatments
SO PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
LA English
DT Article
DE Gut microbiota; Gut-brain axis; Antipsychotics; Dysbiosis; Probiotics;
   Prebiotics
ID INTERNATIONAL SCIENTIFIC ASSOCIATION; SEROTONIN REUPTAKE INHIBITORS;
   FECAL MICROBIOTA; INTESTINAL MICROBIOTA; ANTIMICROBIAL PROPERTIES;
   INSULIN SENSITIVITY; CONSENSUS STATEMENT; METABOLIC SYNDROME; IN-VITRO;
   MECHANISMS
AB Emerging evidence highlighted the essential role played by the microbiota-gut-brain axis in maintaining human homeostasis, including nutrition, immunity, and metabolism. Much recent work has linked the gut microbiota to many psychiatric and neurodegenerative disorders such as depression, schizophrenia, and Alzheimer?s disease. Shared gut microbiota alterations or dysbiotic microbiota have been identified in these separate disorders relative to controls. Much attention has focused on the bidirectional interplay between the gut microbiota and the brain, establishing gut dysbiotic status as a critical factor in psychiatric disorders. Still, the antibiotic-like effect of psychotropic drugs, medications used for the treatment of these disorders, on gut microbiota is largely neglected. In this review, we summarize the current findings on the impact of psychotropics on gut microbiota and how their antimicrobial potency can trigger dysbiosis. We also discuss the potential therapeutic strategies, including probiotics, prebiotics, and fecal transplantation, to attenuate the dysbiosis related to psychotropics intake.
C1 [Chait, Yasmina Ait; Mottawea, Walid; Hammami, Riadh] Univ Ottawa, Sch Nutr Sci, NuGut Res Platform, Fac Hlth Sci, Ottawa, ON K1N 6N5, Canada.
   [Mottawea, Walid] Mansoura Univ, Dept Microbiol & Immunol, Fac Pharm, Mansoura, Egypt.
   [Tompkins, Thomas A.] Rosell Inst Microbiome & Probiot, Montreal, PQ H4P 2R2, Canada.
C3 University of Ottawa; Egyptian Knowledge Bank (EKB); Mansoura University
RP Hammami, R (corresponding author), Univ Ottawa, Sch Nutr Sci, NuGut Res Platform, Fac Hlth Sci, Ottawa, ON K1N 6N5, Canada.
EM riadh.hammami@uottawa.ca
RI Mottawea, Walid/K-6429-2018; Hammami, Riadh/JOZ-9856-2023
OI Hammami, Riadh/0000-0002-3685-5639
FU Natural Sciences and Engineering Research Council of Canada (NSERC)
   [543626-19]; MITACS [IT13530]; Nutrition and Mental Health Master's
   Scholarship, University of Ottawa
FX This study was supported by a grant from the Natural Sciences and
   Engineering Research Council of Canada (NSERC) [No. 543626-19] and
   MITACS [No. IT13530]. Y.A. was supported by the Nutrition and Mental
   Health Master's Scholarship, University of Ottawa.
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PY 2021
VL 108
DI 10.1016/j.pnpbp.2020.110182
EA MAR 2021
PG 11
WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA RS3VT
UT WOS:000643710600006
PM 33232785
DA 2025-06-11
ER

PT J
AU Bauer, LO
AF Bauer, Lance O.
TI Psychiatric and neurophysiological predictors of obesity in HIV/AIDS
SO PSYCHOPHYSIOLOGY
LA English
DT Review
DE Obesity; HIV-1; Contingent negative variation; Impulsivity
ID BODY-MASS INDEX; CONTINGENT NEGATIVE-VARIATION; ACTIVE ANTIRETROVIRAL
   THERAPY; HIV-INFECTED PATIENTS; WEIGHT-LOSS; PROTEASE INHIBITORS;
   METABOLIC SYNDROME; PERSONALITY-DISORDER; VIROLOGICAL RESPONSE;
   DIABETES-MELLITUS
AB The objective of the study was to identify predictors of obesity. One hundred eleven nonobese and 48 obese HIV-1 seropositive patients provided information on medical history and other characteristics. They were then asked to detect the passage of 2-s time intervals while the contingent negative variation (CNV) was recorded. Obese patients were healthier, more likely to be receiving Highly Active Antiretroviral Therapy, and less likely to be substance dependent. Obese patients also exhibited a greater CNV slope and responded prematurely. A path model suggested that CD4+count and protease inhibitor use directly predicted obesity. Depression had no direct effect. However, when incorporated into a hypothetical construct, "mood dysregulation," that also included childhood conduct problems and stimulant dependence, the shared variance among the indicators did predict obesity. This relationship was mediated through premature response preparation (anterior scalp CNV amplitude) and its hypothesized association with impatience/impulsivity.
C1 Univ Connecticut, Ctr Hlth, Dept Psychiat, Sch Med, Farmington, CT 06030 USA.
C3 University of Connecticut
RP Bauer, LO (corresponding author), Univ Connecticut, Ctr Hlth, Dept Psychiat, Sch Med, Farmington, CT 06030 USA.
EM bauer@psychiatry.uchc.edu
RI Bucholz, Kathleen/IXD-3612-2023
FU PHS [R01MH61346]; NIMH; NIDA; NIAAA [P50AA03510, M01RR06192]; NCRR
FX This research was supported by PHS grant R01MH61346 funded jointly by
   NIMH and NIDA. Additional support was provided by grants P50AA03510 and
   M01RR06192 funded by NIAAA and NCRR, respectively.
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NR 111
TC 11
Z9 12
U1 1
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0048-5772
EI 1469-8986
J9 PSYCHOPHYSIOLOGY
JI Psychophysiology
PD NOV
PY 2008
VL 45
IS 6
BP 1055
EP 1063
DI 10.1111/j.1469-8986.2008.00706.x
PG 9
WC Psychology, Biological; Neurosciences; Physiology; Psychology;
   Psychology, Experimental
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Neurosciences & Neurology; Physiology
GA 361AP
UT WOS:000260100200020
PM 18823420
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Fragoulis, GE
   Nikiphorou, E
   McInnes, IB
   Siebert, S
AF Fragoulis, George E.
   Nikiphorou, Elena
   McInnes, Iain B.
   Siebert, Stefan
TI Does Age Matter in Psoriatic Arthritis? A Narrative Review
SO JOURNAL OF RHEUMATOLOGY
LA English
DT Review
DE aging; comorbidities; psoriatic arthritis
ID LATE-ONSET PSORIASIS; QUALITY-OF-LIFE; ELDERLY-PATIENTS;
   RHEUMATOID-ARTHRITIS; GENERAL-POPULATION; CARDIOVASCULAR EVENTS;
   MYOCARDIAL-INFARCTION; METABOLIC SYNDROME; INCIDENCE RATES; DISEASE
   ONSET
AB Psoriatic arthritis (PsA) affects approximately 0.8% of the general population. PsA, together with psoriasis (PsO), constitute psoriatic disease (PsD). Comorbidities play an important role in the clinical expression and treatment of PsD. Aging adds another level of complexity, partly because age directly accrues increasing risk of comorbidities, but also because of its complex interactions with several factors such as depression and social determinants. Aging seems to have a "paradoxical association" with cardiovascular comorbidities, for which the relative risk is more pronounced in younger patients with PsD. It also affects treatment decisions and treatment response in patients with PsD. Finally, there is convincing evidence that there are clinical, genetic, and histopathological differences between early- and late-onset PsA and PsO. Herein, we review the effect of age in patients with PsD, with a focus on PsA, highlighting the need to consider this factor in routine clinical practice as well as in research.
C1 [Fragoulis, George E.] Univ Glasgow, Inst Infect Immun & Inflammat, Glasgow, Lanark, Scotland.
   [Fragoulis, George E.] Natl & Kapodistrian Univ Athens, Laiko Gen Hosp, Dept Propaedeut Internal Med 1, Athens, Greece.
   [Nikiphorou, Elena] Kings Coll London, Dept Inflammat Biol, London, England.
   [McInnes, Iain B.] Univ Glasgow, Inst Infect Immun & Inflammat, Glasgow, Lanark, Scotland.
C3 University of Glasgow; National & Kapodistrian University of Athens;
   Laiko General Hospital; University of London; King's College London;
   University of Glasgow
RP Fragoulis, GE (corresponding author), Natl & Kapodistrian Univ Athens, Laiko Gen Hosp, Dept Propaedeut Internal Med 1, Athens, Greece.
EM geofragoul@yahoo.gr
RI Nikiphorou, Elena/AAI-1523-2019; McInnes, Iain/ACS-0958-2022
OI Siebert, Stefan/0000-0002-1802-7311; Fragoulis,
   George/0000-0003-4932-7023
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NR 87
TC 23
Z9 23
U1 0
U2 0
PU J RHEUMATOL PUBL CO
PI TORONTO
PA 365 BLOOR ST E, STE 901, TORONTO, ONTARIO M4W 3L4, CANADA
SN 0315-162X
EI 1499-2752
J9 J RHEUMATOL
JI J. Rheumatol.
PD OCT 1
PY 2022
VL 49
IS 10
BP 1085
EP 1091
DI 10.3899/jrheum.210349
PG 7
WC Rheumatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Rheumatology
GA O4SO6
UT WOS:001043730700004
PM 34393099
OA Green Accepted, Green Submitted, Bronze
DA 2025-06-11
ER

PT J
AU Levitan, RD
   Wendland, B
AF Levitan, Robert D.
   Wendland, Barbara
TI Novel "Thrifty" Models of Increased Eating Behaviour
SO CURRENT PSYCHIATRY REPORTS
LA English
DT Article
DE Thrifty genotype hypothesis; Thrifty phenotype hypothesis; Seasonality;
   Psychosocial adversity; Eating disorders; Psychiatry
ID SEASONAL AFFECTIVE-DISORDER; BODY-MASS INDEX; DIABETES-MELLITUS; MAJOR
   DEPRESSION; OBESITY; CHILDHOOD; GENE; PHENOTYPES; ASSOCIATION;
   COMORBIDITY
AB The thrifty genotype and phenotype hypotheses were developed to explain the rapid increase in diabetes and obesity in developed countries around the world. Most subsequent "thrifty" research has focused on the early developmental origins of the metabolic syndrome and cardio-metabolic disease. The goal of this manuscript is to review an emerging line of research that uses a similar thrifty framework to understand the early developmental origins of eating-related phenotypes that have primary relevance to many psychiatric disorders. Given the important role of environmental adversity in various psychiatric disorders that involve overeating, and their early age of onset, it is likely that several thrifty mechanisms are relevant in this regard. Understanding the early origins of increased eating behaviour based on a thrifty model might point the way to highly targeted preventative interventions during critical periods of development, and provide a new way of addressing these common and difficult to treat disorders.
C1 [Levitan, Robert D.] Campbell Family Mental Hlth Res Inst, Ctr Addict & Mental Hlth, Toronto, ON M6J 1H4, Canada.
   [Levitan, Robert D.] Univ Toronto, Dept Psychiat, Toronto, ON, Canada.
   [Levitan, Robert D.] Univ Toronto, Dept Physiol, Toronto, ON, Canada.
   [Levitan, Robert D.; Wendland, Barbara] Univ Toronto, Inst Med Sci, Toronto, ON, Canada.
C3 University of Toronto; Centre for Addiction & Mental Health - Canada;
   University of Toronto; University of Toronto; University of Toronto
RP Levitan, RD (corresponding author), Univ Toronto, Inst Med Sci, Toronto, ON, Canada.
EM Robert.Levitan@camh.ca
OI Levitan, Robert/0000-0003-1306-3847
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NR 51
TC 4
Z9 5
U1 2
U2 31
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1523-3812
EI 1535-1645
J9 CURR PSYCHIAT REP
JI Curr. Psychiatry Rep.
PD NOV
PY 2013
VL 15
IS 11
AR 408
DI 10.1007/s11920-013-0408-x
PG 6
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 241SG
UT WOS:000326187300005
PM 24057159
DA 2025-06-11
ER

PT J
AU van Buren, DJ
   Tibbs, TL
AF van Buren, Dorothy J.
   Tibbs, Tiffany L.
TI Lifestyle Interventions to Reduce Diabetes and Cardiovascular Disease
   Risk Among Children
SO CURRENT DIABETES REPORTS
LA English
DT Article
DE Cardiovascular; Diabetes; Risk factors; Lifestyle interventions;
   Pediatric
ID SUGAR-SWEETENED BEVERAGES; METABOLIC SYNDROME; PHYSICAL-ACTIVITY;
   CHILDHOOD OBESITY; WEIGHT CHANGE; PREVENTION; ADOLESCENTS; OVERWEIGHT;
   FAMILY; MULTILEVEL
AB Diseases once associated with older adulthood, type 2 diabetes and cardiovascular disease, are increasingly diagnosed in children and adolescents. Interventions designed to assist adults in modifying dietary and physical activity habits have been shown to help prevent the development of type 2 diabetes and cardiovascular disease in adults. Given the unfortunate rise in both of these diseases in pediatric populations, it is increasingly important to begin prevention efforts in childhood or prenatally. There is strong empirical support for utilizing lifestyle interventions to prevent these diseases in adults; it is not clear whether the same holds true for pediatric populations. The present review examines lifestyle management efforts to prevent type 2 diabetes and cardiovascular disease in children across socioecological levels. Recommendations are made for expanding the traditional focus of lifestyle interventions from dietary and physical activity behaviors to target additional risks for these diseases such as smoking and depression in youth.
C1 [van Buren, Dorothy J.] Washington Univ, Sch Med, Dept Psychiat, St Louis, MO 63110 USA.
   [Tibbs, Tiffany L.] Univ Phoenix, Sch Adv Studies, Phoenix, AZ 85034 USA.
   [Tibbs, Tiffany L.] Univ Phoenix, Coll Social Sci, Phoenix, AZ 85034 USA.
C3 Washington University (WUSTL); University of Phoenix; University of
   Phoenix
RP van Buren, DJ (corresponding author), Washington Univ, Sch Med, Dept Psychiat, Campus Box 8134,660 South Euclid, St Louis, MO 63110 USA.
EM vanbured@psychiatry.wustl.edu; tltibbs@email.phoenix.edu
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NR 86
TC 16
Z9 17
U1 0
U2 23
PU CURRENT MEDICINE GROUP
PI PHILADELPHIA
PA 400 MARKET STREET, STE 700, PHILADELPHIA, PA 19106 USA
SN 1534-4827
EI 1539-0829
J9 CURR DIABETES REP
JI Curr. Diabetes Rep.
PD DEC
PY 2012
VL 14
IS 12
BP 557
EP U55
DI 10.1007/s11892-014-0557-2
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism
GA AS9IK
UT WOS:000344556300006
PM 25344792
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Kulie, T
   Slattengren, A
   Redmer, J
   Counts, H
   Eglash, A
   Schrager, S
AF Kulie, Teresa
   Slattengren, Andrew
   Redmer, Jackie
   Counts, Helen
   Eglash, Anne
   Schrager, Sarina
TI Obesity and Women's Health: An Evidence-Based Review
SO JOURNAL OF THE AMERICAN BOARD OF FAMILY MEDICINE
LA English
DT Review
DE Evidence-based; Obesity; Women's Health
ID BODY-MASS INDEX; ENDOMETRIAL CANCER-RISK; BREAST-FEEDING SUCCESS;
   LOW-BACK-PAIN; MATERNAL OBESITY; KNEE OSTEOARTHRITIS; BARIATRIC SURGERY;
   METABOLIC SYNDROME; CESAREAN DELIVERY; FAT DISTRIBUTION
AB Obesity negatively impacts the health of women in many ways. Being overweight or obese increases the relative risk of diabetes and coronary artery disease in women. Women who are obese have a higher risk of low back pain and knee osteoarthritis. Obesity negatively affects both contraception and fertility as well. Maternal obesity is linked with higher rates of cesarean section as well as higher rates of high-risk obstetrical conditions such as diabetes and hypertension. Pregnancy outcomes are negatively affected by maternal obesity (increased risk of neonatal mortality and malformations). Maternal obesity is associated with a decreased intention to breastfeed, decreased initiation of breastfeeding, and decreased duration of breastfeeding. There seems to be an association between obesity and depression in women, though cultural factors may influence this association. Obese women are at higher risk for multiple cancers, including endometrial cancer, cervical cancer, breast cancer, and perhaps ovarian cancer. (J Am Board Fam Med 2011;24:75-85.)
C1 [Kulie, Teresa; Slattengren, Andrew; Redmer, Jackie; Counts, Helen; Eglash, Anne; Schrager, Sarina] Univ Wisconsin, Dept Family Med, Madison, WI 53715 USA.
C3 University of Wisconsin System; University of Wisconsin Madison
RP Schrager, S (corresponding author), Univ Wisconsin, Dept Family Med, 777 S Mills St, Madison, WI 53715 USA.
EM sbschrag@wisc.edu
OI Slattengren, Andrew/0000-0002-4814-7031
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NR 103
TC 194
Z9 224
U1 0
U2 39
PU AMER BOARD FAMILY MEDICINE
PI LEXINGTON
PA 2228 YOUNG DR, LEXINGTON, KY 40505 USA
SN 1557-2625
EI 1558-7118
J9 J AM BOARD FAM MED
JI J. Am. Board Fam. Med.
PD JAN-FEB
PY 2011
VL 24
IS 1
BP 75
EP 85
DI 10.3122/jabfm.2011.01.100076
PG 11
WC Primary Health Care; Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 702TZ
UT WOS:000285920100011
PM 21209347
OA Bronze
DA 2025-06-11
ER

PT J
AU Barnes, DE
   Yaffe, K
AF Barnes, Deborah E.
   Yaffe, Kristine
TI The projected effect of risk factor reduction on Alzheimer's disease
   prevalence
SO LANCET NEUROLOGY
LA English
DT Review
ID COGNITIVE IMPAIRMENT; PHYSICAL-ACTIVITY; DEPRESSIVE SYMPTOMS; INCIDENT
   DEMENTIA; VASCULAR-DISEASE; BLOOD-PRESSURE; GLOBAL BURDEN; MEDITERRANEAN
   DIET; METABOLIC SYNDROME; OLDER-ADULTS
AB At present, about 33-9 million people worldwide have Alzheimer's disease (AD), and prevalence is expected to triple over the next 40 years. The aim of this Review was to summarise the evidence regarding seven potentially modifiable risk factors for AD: diabetes, midlife hypertension, midlife obesity, smoking, depression, cognitive inactivity or low educational attainment, and physical inactivity. Additionally, we projected the effect of risk factor reduction on AD prevalence by calculating population attributable risks (the percent of cases attributable to a given factor) and the number of AD cases that might be prevented by risk factor reductions of 10% and 25% worldwide and in the USA. Together, up to half of AD cases worldwide (17.2 million) and in the USA (2.9 million) are potentially attributable to these factors. A 10-25% reduction in all seven risk factors could potentially prevent as many as 1.1-3.0 million AD cases worldwide and 184000-492000 cases in the USA.
C1 [Barnes, Deborah E.; Yaffe, Kristine] Univ Calif San Francisco, Dept Psychiat, San Francisco, CA 94121 USA.
   [Yaffe, Kristine] Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94121 USA.
   [Yaffe, Kristine] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94121 USA.
   [Barnes, Deborah E.; Yaffe, Kristine] San Francisco VA Med Ctr, San Francisco, CA USA.
C3 University of California System; University of California San Francisco;
   University of California System; University of California San Francisco;
   University of California System; University of California San Francisco;
   US Department of Veterans Affairs; Veterans Health Administration (VHA);
   San Francisco VA Medical Center
RP Barnes, DE (corresponding author), Univ Calif San Francisco, Dept Psychiat, 4150 Clement Sreet,151R, San Francisco, CA 94121 USA.
EM deborah.barnes@ucsf.edu
RI Yaffe, Kristine/LLL-8209-2024
FU Alzheimer's Association; NARSAD; National Institute on Aging [K24
   AG031155]; University of California, San Francisco, School of Medicine
FX DEB is supported in part by the Alzheimer's Association, NARSAD, and the
   University of California, San Francisco, School of Medicine. KY is
   supported in part by the National Institute on Aging (K24 AG031155).
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   2011, OVERWEIGHT OBESITY
   2010, INT DATA BASE IDB
NR 101
TC 1964
Z9 2154
U1 5
U2 366
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1474-4422
EI 1474-4465
J9 LANCET NEUROL
JI Lancet Neurol.
PD SEP
PY 2011
VL 10
IS 9
BP 819
EP 828
DI 10.1016/S1474-4422(11)70072-2
PG 10
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology
GA 815NM
UT WOS:000294532300010
PM 21775213
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Maldonado, MD
   Reiter, RJ
   Pérez-San-Gregorio, MA
AF Maldonado, Maria D.
   Reiter, Russel J.
   Perez-San-Gregorio, Maria A.
TI Melatonin as a potential therapeutic agent in psychiatric illness
SO HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL
LA English
DT Review
DE melatonin; immune function; neuroinflammation; major psychiatric
   disorders
ID RESPIRATORY-DISTRESS-SYNDROME; METABOLIC SYNDROME; DOUBLE-BLIND;
   CYTOKINE ALTERATIONS; EXOGENOUS MELATONIN; HUMAN-LYMPHOCYTES;
   BIPOLAR-DISORDER; PRETERM NEWBORNS; REACTIVE OXYGEN; IMMUNE-SYSTEM
AB The aim of this review was to summarize the potential use of melatonin in the treatment of mental disorders, specifically bipolar disorders, depression, and schizophrenia. To date, melatonin has been most commonly used in psychiatry because of its hypnotic, rhythm resynchronizing, and antioxidant actions. Here, we examine other properties of the melatonin including its anti-inflammatory, anti nociceptive, anxiolytic, and drug detoxification actions as well as its protective effects against neural loss. The brain is an intricate sensory and motor organ which receives information from both the external and internal environments. It transduces information into complex chemical and electrical signals which are transmitted throughout the central nervous system (CNS) and the organism. The pathogenesis of mental disorders remains ambiguous and neuroinflammation has been proposed as a causative agent. We consider the potential contributions of melatonin as therapeutic agent in CNS and during neuroinflammation in mental disorders. Copyright (C) 2009 John Wiley & Sons, Ltd.
C1 [Maldonado, Maria D.] Univ Seville, Sch Med, Dept Med Biochem & Mol Biol, E-41009 Seville, Spain.
   [Reiter, Russel J.] Univ Texas Hlth Sci Ctr San Antonio, Dept Cellular & Struct Biol, San Antonio, TX 78229 USA.
   [Perez-San-Gregorio, Maria A.] Univ Seville, Dept Personal Evaluat & Treatment Psychol, E-41009 Seville, Spain.
C3 University of Sevilla; University of Texas System; University of Texas
   Health Science Center at San Antonio; University of Sevilla
RP Maldonado, MD (corresponding author), Univ Seville, Sch Med, Dept Med Biochem & Mol Biol, Avda Sanchez Pizjuan 4, E-41009 Seville, Spain.
EM aibar@us.es
RI Reiter, Russel/D-3221-2009; Perez San Gregorio, Angeles/AEF-7621-2022;
   Maldonado y Aibar, Maria Dolores/A-3847-2008
OI Perez San Gregorio, Angeles/0000-0002-1308-5002; Maldonado y Aibar,
   Maria Dolores/0000-0003-1375-447X
FU Seville University; Consejeria de Innovacion, Ciencia y Empresa, Junta
   de Andalucia, Spain [CTS-160]
FX Ma Dolores Maldonado y Aibar acknowledges partial support from Seville
   University (area of Immunology) and research group CTS-160 (Consejeria
   de Innovacion, Ciencia y Empresa, Junta de Andalucia, Spain). The
   authors have declared that no conflict of interest exists.
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NR 133
TC 46
Z9 47
U1 0
U2 13
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0885-6222
EI 1099-1077
J9 HUM PSYCHOPHARM CLIN
JI Hum. Psychopharmacol.-Clin. Exp.
PD JUL
PY 2009
VL 24
IS 5
BP 391
EP 400
DI 10.1002/hup.1032
PG 10
WC Clinical Neurology; Pharmacology & Pharmacy; Psychiatry; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry;
   Psychology
GA 472FZ
UT WOS:000268116900003
PM 19551767
DA 2025-06-11
ER

PT J
AU Palmese, LB
   Ratliff, JC
   Reutenauer, EL
   Tonizzo, KM
   Grilo, CM
   Tek, C
AF Palmese, Laura B.
   Ratliff, Joseph C.
   Reutenauer, Erin L.
   Tonizzo, K. Melek
   Grilo, Carlos M.
   Tek, Cenk
TI Prevalence of night eating in obese individuals with schizophrenia and
   schizoaffective disorder
SO COMPREHENSIVE PSYCHIATRY
LA English
DT Article
ID METABOLIC SYNDROME; ENERGY-INTAKE; FOOD-INTAKE; TRIAL; ASSOCIATION;
   SERTRALINE; INSOMNIA; GENDER; INDEX; SLEEP
AB The prevalence of Night Eating Syndrome (NES) in the general population is estimated to be 1.5%, however, the rates among individuals with schizophrenia and schizoaffective disorder are not yet established. This study sought to examine the frequency and correlates of NES-related behaviors in a sample of obese patients with schizophrenia. One-hundred outpatients diagnosed with schizophrenia or schizoaffective disorders completed the self-report Night Eating Questionnaire (NEQ) and were then interviewed as a follow-up for the specific assessment of NES. Based on a diagnostic interview, 12% of this sample met full criteria for NES, with an additional 10% meeting partial criteria for NES. Based on the NEQ alone, 8% met full criteria with an additional 8% meeting partial criteria. Night eating behaviors were associated with increased insomnia and depression. Our findings suggest that screening for NES among patients with serious mental illness may efficiently identify a subgroup with additional clinical needs. (C) 2013 Elsevier Inc. All rights reserved.
C1 [Palmese, Laura B.; Ratliff, Joseph C.; Reutenauer, Erin L.; Grilo, Carlos M.; Tek, Cenk] Yale Univ, Sch Med, New Haven, CT 06520 USA.
   [Tonizzo, K. Melek] Univ Utah, Salt Lake City, UT 84112 USA.
C3 Yale University; Utah System of Higher Education; University of Utah
RP Reutenauer, EL (corresponding author), Yale Univ, Sch Med, Dept Psychiat, Connecticut Mental Hlth Ctr, 34 Pk St,Room 10, New Haven, CT 06520 USA.
EM laura.palmese@yale.edu; erin.reutenauer@yale.edu
RI Tek, Cenk/M-1552-2019
OI Grilo, Carlos/0000-0003-0245-3444
FU National Institute of Mental Health (NIMH) [5R01MH080048]
FX This research was partially supported by National Institute of Mental
   Health (NIMH) grant 5R01MH080048 to Dr Tek.
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NR 32
TC 21
Z9 22
U1 0
U2 9
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0010-440X
EI 1532-8384
J9 COMPR PSYCHIAT
JI Compr. Psychiat.
PD APR
PY 2013
VL 54
IS 3
BP 276
EP 281
DI 10.1016/j.comppsych.2012.07.014
PG 6
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 121LO
UT WOS:000317246500010
PM 22959340
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Wang, T
   Mao, LJ
   Wang, JH
   Li, PJ
   Liu, XD
   Wu, WB
AF Wang, Ting
   Mao, Lijuan
   Wang, Jihong
   Li, Peijun
   Liu, Xiaodan
   Wu, Weibing
TI Influencing Factors and Exercise Intervention of Cognitive Impairment in
   Elderly Patients with Chronic Obstructive Pulmonary Disease
SO CLINICAL INTERVENTIONS IN AGING
LA English
DT Review
DE chronic obstructive pulmonary disease; elderly people; cognitive
   function; influencing factors; exercise training
ID SMALL VESSEL DISEASE; PHYSICAL-ACTIVITY; CEREBRAL MICROBLEEDS; METABOLIC
   SYNDROME; OLDER-ADULTS; BRAIN; INFLAMMATION; DEPRESSION; HEALTH; IMPACT
AB Chronic obstructive pulmonary disease (COPD) is a common respiratory condition characterized by airflow limitation in the elderly. Airflow limitation is partially reversible and progressive. COPD not only causes a gradual decline in lung function but also affects the function of other systems throughout the body; it also has adverse effects on the central nervous system that can lead to cognitive impairment, especially in elderly patients. Therefore, understanding the influencing factors of cognitive impairment in elderly patients with COPD and applying early intervention are crucial in improving the quality of life of patients and reducing the burden on their families and society. This article mainly discusses the related factors of cognitive impairment in elderly patients with COPD and expands the possible mechanism of exercise in improving cognitive impairment in patients with COPD to provide a reference for the clinical prevention and treatment of cognitive impairment in elderly patients with COPD.
C1 [Wang, Ting; Mao, Lijuan; Wang, Jihong; Li, Peijun; Wu, Weibing] Shanghai Univ Sport, Dept Sports Med, Shanghai 200438, Peoples R China.
   [Liu, Xiaodan] Shanghai Univ Tradit Chinese Med, Sch Rehabil Sci, Shanghai 201203, Peoples R China.
   [Liu, Xiaodan] Shanghai Acad Tradit Chinese Med, Inst Rehabil Med, Shanghai 201203, Peoples R China.
C3 Shanghai University of Sport; Shanghai University of Traditional Chinese
   Medicine
RP Wu, WB (corresponding author), Shanghai Univ Sport, Dept Sports Med, Shanghai 200438, Peoples R China.; Liu, XD (corresponding author), Shanghai Univ Tradit Chinese Med, Sch Rehabil Sci, Shanghai 201203, Peoples R China.
EM hzhp403@126.com; wwb75@126.com
RI liu, xiaodan/GQA-3048-2022; Wang, Jihong/ITU-6463-2023; Wang,
   Ting/AAF-1262-2019
FU National Natural Science Foundation of China [81902307]
FX The authors would like to thank Mr Jian Li, Mr Zhaoyu Yang, Ms Hongxia
   Duan and Ms Yahui Yang for their Information gathering and assistance
   with this study. This work was supported by the National Natural Science
   Foundation of China (No 81902307).
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NR 87
TC 37
Z9 46
U1 5
U2 56
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
EI 1178-1998
J9 CLIN INTERV AGING
JI Clin. Interv. Aging
PY 2020
VL 15
BP 557
EP 566
DI 10.2147/CIA.S245147
PG 10
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA LG3NW
UT WOS:000528012700001
PM 32368022
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Sotos-Prieto, M
   Jin, Q
   Rainey, D
   Coyle, M
   Kales, SN
AF Sotos-Prieto, Mercedes
   Jin, Qi
   Rainey, David
   Coyle, Maria
   Kales, Stefanos N.
TI Barriers and solutions to improving nutrition among fire academy
   recruits: a qualitative assessment
SO INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION
LA English
DT Article
DE Firefighters; fire academy; Mediterranean diet; lifestyle intervention
   programme; qualitative study
ID MEDITERRANEAN DIET; PHYSICAL-ACTIVITY; METABOLIC SYNDROME; US
   FIREFIGHTERS; INTERVENTIONS; ADHERENCE; RISK; WEIGHT; METAANALYSIS;
   HEALTH
AB The primary health concerns among US firefighters are cardiovascular disease, cancer, and depression and occur in an occupational setting where dietary habits are suboptimal. To understand if a diet or lifestyle modification works in a fire academy training setting, it is important to evaluate the cultural barriers and challenges that might be faced. A semi-structured telephone interview method followed by a focus group was used to gather common themes among fire service leaders. Twelve leaders participated in the telephonic interviews and a subset of five in the subsequent group session. Five main themes were identified. The study identified a need for staff and recruits to develop a cohesive culture that facilitates long-term change. Participants reported that incentives for good choices and the elimination of certain poor choices from the food environment would promote healthier choices. The study supports an intervention using education of fire recruits and modifications of the fire academy food environment.
C1 [Sotos-Prieto, Mercedes; Jin, Qi; Coyle, Maria] Ohio Univ, Sch Appl Hlth Sci & Wellness, Div Food & Nutr Sci, Athens, OH 45701 USA.
   [Sotos-Prieto, Mercedes] Ohio Univ, Diabet Inst, Athens, OH 45701 USA.
   [Sotos-Prieto, Mercedes; Rainey, David; Kales, Stefanos N.] Harvard TH Chan Sch Publ Hlth, Dept Environm Hlth, Boston, MA 02115 USA.
C3 University System of Ohio; Ohio University; University System of Ohio;
   Ohio University; Harvard University; Harvard T.H. Chan School of Public
   Health
RP Sotos-Prieto, M (corresponding author), Ohio Univ, Sch Appl Hlth Sci & Wellness, Div Food & Nutr Sci, Athens, OH 45701 USA.; Sotos-Prieto, M (corresponding author), Harvard TH Chan Sch Publ Hlth, Dept Environm Hlth, Boston, MA 02115 USA.
EM sotospri@ohio.edu
RI PRIETO, MERCEDES/F-9180-2013
OI Sotos-Prieto, Mercedes/0000-0001-9127-2586; , Maria
   Coyle/0009-0003-4444-632X
FU NIOSH CDC HHS [T42 OH008416] Funding Source: Medline
CR Agnoli C, 2018, NUTR DIABETES, V8, DOI 10.1038/s41387-018-0023-3
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NR 40
TC 14
Z9 16
U1 0
U2 9
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0963-7486
EI 1465-3478
J9 INT J FOOD SCI NUTR
JI Int. J. Food Sci. Nutr.
PD AUG 18
PY 2019
VL 70
IS 6
BP 771
EP 779
DI 10.1080/09637486.2019.1570087
PG 9
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Food Science & Technology; Nutrition & Dietetics
GA IG0YH
UT WOS:000473516400010
PM 30764673
OA Green Accepted, Green Submitted
DA 2025-06-11
ER

PT J
AU Seong, E
   Bose, S
   Han, SY
   Song, EJ
   Lee, M
   Nam, YD
   Kim, H
AF Seong, Eunhak
   Bose, Shambhunath
   Han, Song-Yi
   Song, Eun-Ji
   Lee, Myeongjong
   Nam, Young-Do
   Kim, Hojun
TI Positive influence of gut microbiota on the effects of Korean red
   ginseng in metabolic syndrome: a randomized, double-blind,
   placebo-controlled clinical trial
SO EPMA JOURNAL
LA English
DT Article
DE Korean red ginseng; Herbal medicine; Metabolic syndrome; Patient
   stratification; Blood serum; Biomarker panel; Molecular pathways;
   Oxidative stress; Inflammation; ROS detoxification; Lipid metabolic
   biomarkers; Hyperlipidemia; Glucose homeostasis; Insulin level;
   Anthropometric parameters; Vital signs; Fat mass; BMI; Gender;
   Predictive preventive personalized medicine (PPPM; 3PM); Individual
   enterotype; Clinical trial; Gut microbiome profile; Drug response;
   Treatment strategy; Blood pressure; 16S rRNA gene sequencing; HOMA-IR
ID HIGH-FAT DIET; HUMAN INTESTINAL MICROFLORA; PANAX-GINSENG; OXIDATIVE
   STRESS; VISCERAL FAT; ACIDIC POLYSACCHARIDE; LIPID-METABOLISM;
   BLOOD-PRESSURE; UNITED-STATES; OBESITY
AB Background Ginseng, a traditional herbal medicine, has been used for thousands of years to treat various diseases including metabolic syndrome (MS). However, the underlying mechanism(s) of such beneficial actions of ginseng against MS is poorly understood. Emerging evidence indicates a close association of the host gut microbiota with MS. The present study was conducted to examine, whether the beneficial effects of Korean red ginseng (KRG) against MS could be influenced by gut microbial population and whether gut microbial profile could be considered a valuable biomarker for targeted treatment strategy for MS in compliance with the predictive, preventive, and personalized medicine (PPPM / 3PM). Methods This clinical study was a randomized, double-blind, placebo-controlled trial evaluating the effects of KRG treatment for 8 weeks on patients with MS. The anthropometric parameters, vital signs, metabolic biomarkers, and gut microbial composition through 16S rRNA gene sequencing were assessed at the baseline and endpoint. The impact of KRG was also evaluated after categorizing the subjects into responders and non-responders, as well as enterotypes 1 and 2 based on their gut microbial profile at the baseline. Results Fifty out of 60 subjects who meet the MS criteria completed the trial without showing adverse reactions. The KRG treatment caused a significant decrease in systolic blood pressure (SBP). Microbial analysis revealed a decrease in Firmicutes, Proteobacteria, and an increase in Bacteroidetes in response to KRG. In patient stratification analysis, the responders showing marked improvement in the serum levels of lipid metabolic biomarkers TC and LDL due to the KRG treatment exhibited higher population of both the family Lachnospiraceae and order Clostridiales compared to the non-responders. The homeostasis model assessment-insulin resistance (HOMA-IR) and insulin level were decreased in enterotype 1 (Bacteroides-abundant group) and increased in enterotype 2 (prevotella-abundant group) following the KRG treatment. Conclusion In this study, the effects of KRG on the glucose metabolism in MS patients were influenced by the relative abundances of gut microbial population and differed according to the individual enterotype. Therefore, the analysis of enterotype categories is considered to be helpful in predicting the effectiveness of KRG on glucose homeostasis of MS patients individually. This will further help to decide on the appropriate treatment strategy for MS, in compliance with the perspective of PPPM.
C1 [Seong, Eunhak; Bose, Shambhunath; Han, Song-Yi; Lee, Myeongjong; Kim, Hojun] Dongguk Univ, Dept Rehabil Med Korean Med, Gyeonggi Do 10326, South Korea.
   [Song, Eun-Ji; Nam, Young-Do] Korea Food Res Inst, Res Grp Healthcare, Wanju Gun 55365, South Korea.
C3 Dongguk University; Korea Food Research Institute (KFRI)
RP Kim, H (corresponding author), Dongguk Univ, Dept Rehabil Med Korean Med, Gyeonggi Do 10326, South Korea.; Nam, YD (corresponding author), Korea Food Res Inst, Res Grp Healthcare, Wanju Gun 55365, South Korea.
EM youngdo98@kfri.re.kr; kimklar@dongguk.ac.kr
RI Song, Eun-Ji/HDO-8376-2022; Bose, Shambhunath/HKW-2568-2023; Kim,
   Hojun/AAB-8405-2020
OI Han, Song-Yi/0000-0001-9873-7761; Song, Eun-Ji/0000-0002-7448-5026; Kim,
   Hojun/0000-0003-1038-0142
FU Korea Ginseng Corporation (Seoul, Republic of Korea); Main Research
   Program of the Korea Food Research Institute - Ministry of Science and
   ICT [E0170601-04]
FX This study was supported by the Korea Ginseng Corporation (Seoul,
   Republic of Korea) and by the Main Research Program (E0170601-04) of the
   Korea Food Research Institute funded by the Ministry of Science and ICT.
   The funders had no role in the design and conduct of the study;
   collection, management, analysis, and interpretation of the data;
   preparation, review, or approval of the manuscript; and decision to
   submit the manuscript for publication.
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NR 134
TC 19
Z9 21
U1 1
U2 31
PU SPRINGER INT PUBL AG
PI CHAM
PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND
SN 1878-5077
EI 1878-5085
J9 EPMA J
JI EPMA J.
PD JUN
PY 2021
VL 12
IS 2
SI SI
BP 177
EP 197
DI 10.1007/s13167-021-00243-4
EA JUN 2021
PG 21
WC Medicine, General & Internal; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Research & Experimental Medicine
GA SP9TF
UT WOS:000657599200001
PM 34194584
OA Green Published
DA 2025-06-11
ER

PT J
AU Otieno, P
   Asiki, G
   Aheto, JMK
   Wilunda, C
   Sanya, RE
   Wami, W
   Mwanga, D
   Agyemang, C
AF Otieno, Peter
   Asiki, Gershim
   Aheto, Justice Moses K.
   Wilunda, Calistus
   Sanya, Richard E.
   Wami, Welcome
   Mwanga, Daniel
   Agyemang, Charles
TI Cardiometabolic Multimorbidity Associated with Moderate and Severe
   Disabilities: Results from the Study on Global AGEing and Adult Health
   (SAGE) Wave 2 in Ghana and South Africa
SO REVISTA DE PESQUISA-CUIDADO E FUNDAMENTAL ONLINE
LA English
DT Article
DE Cardiometabolic diseases; multimorbidity; disability; latent class
   analysis
ID METABOLIC SYNDROME; CHRONIC DISEASES; PREVALENCE; ORGANIZATION;
   COMORBIDITY; STROKE; HYPERTENSION; DEPRESSION; COUNTRIES
AB Background: Integrated management of cardiometabolic diseases is crucial in improving the quality of life of older persons. The objective of the study was to identify clusters of cardiometabolic multimorbidity associated with moderate and severe disabilities in Ghana and South Africa.Methods: Data were from the World Health Organization (WHO) study on global AGEing and adult health (SAGE) Wave-2 (2015) conducted in Ghana and South Africa. We analysed the clustering of cardiometabolic diseases including angina, stroke, diabetes, obesity, and hypertension with unrelated conditions such as asthma, chronic lung disease, arthritis, cataracts, and depression. The WHO Disability Assessment Instrument version 2.0 was used to assess functional disability. We used latent class analysis to calculate the multimorbidity classes and disability severity levels. Ordinal logistic regression was used to identify the clusters of multimorbidity associated with moderate and severe disabilities.Results: Data from 4,190 adults aged over 50 years were analysed. The prevalence of moderate and severe disabilities was 27.0% and 8.9% respectively. Four latent classes of multimorbidity were identified. These included a relatively healthy group with minimal cardiometabolic multimorbidity (63.5%), general and abdominal obesity (20.5%), hypertension, abdominal obesity, diabetes, cataracts, and arthritis (10.0%), and angina, chronic lung disease, asthma, and depression (6.0%). Compared to the participants with minimal cardiometabolic multimorbidity, the odds of moderate and severe disabilities were higher among participants with multimorbidity comprising hypertension, abdominal obesity, diabetes, cataract and arthritis [aOR = 3.0; 95% CI 1.6 to 5.6], and those with angina, chronic lung disease, asthma and depression [aOR = 2.7; 95% CI 1.6 to 4.5].Conclusions: Cardiometabolic diseases among older persons in Ghana and South Africa cluster in distinct multimorbidity patterns that are significant predictors of functional disabilities. This evidence may be useful for defining disability prevention strategies and long-term care for older persons living with or at risk of cardiometabolic multimorbidity in sub-Saharan Africa.
C1 [Otieno, Peter] African Populat & Hlth Res Ctr, POB 10787-00100, Nairobi, Kenya.
   [Otieno, Peter; Asiki, Gershim; Wilunda, Calistus; Sanya, Richard E.; Mwanga, Daniel] African Populat & Hlth Res Ctr, Nairobi, Kenya.
   [Otieno, Peter; Agyemang, Charles] Univ Amsterdam, Amsterdam Publ Hlth Res Inst, Dept Publ & Occupat Hlth, Amsterdam UMC, Amsterdam, Netherlands.
   [Otieno, Peter; Wami, Welcome] Amsterdam Inst Global Hlth & Dev, Amsterdam, Netherlands.
   [Asiki, Gershim] Karolinska Inst, Dept Womens & Childrens Hlth, Stockholm, Sweden.
   Univ Ghana, Coll Hlth Sci, Sch Publ Hlth, Dept Biostat, Accra, Ghana.
   [Wami, Welcome] Univ Amsterdam, Dept Global Hlth, Paasheuvelweg 25, Amsterdam, Netherlands.
C3 African Population & Health Research Centre; African Population & Health
   Research Centre; University of Amsterdam; Vrije Universiteit Amsterdam;
   Karolinska Institutet; University of Ghana; University of Amsterdam
RP Otieno, P (corresponding author), African Populat & Hlth Res Ctr, POB 10787-00100, Nairobi, Kenya.
EM pootienoh@gmail.com
RI Otieno, Peter/AAT-7225-2020; Mwanga, Daniel/ISU-1401-2023; Asiki,
   Gershim/K-3846-2016; Aheto, Justice Moses K./H-8890-2019
OI Mwanga, Daniel/0000-0003-3907-1538; Wilunda,
   Calistus/0000-0002-6606-6534; Sanya, Richard/0000-0001-6348-9075; Aheto,
   Justice Moses K./0000-0003-1384-2461
FU US National Institute on Aging [OGHA 04034785, YA1323-08-CN-0020,
   Y1-AG-1005-01]; World Health Organization [R01 AG034479-64401A1]
FX Funding Financial support was provided by the US National Institute on
   Aging through Interagency Agreements (OGHA 04034785;
   YA1323-08-CN-0020;Y1-AG-1005-01) with the World Health Organization and
   a Research Project Grant (R01 AG034479-64401A1) .
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NR 67
TC 7
Z9 7
U1 0
U2 2
PU UNIV FEDERAL ESTADO RIO DE JANEIRO, PROGRAMA POS-GRADUACAO & ENFERMAGEM
PI RIO DE JANEIRO
PA C/O FERNANDO RAMOS PORTO, AV PASTEU 296, URCA, RIO DE JANEIRO, 00000,
   BRAZIL
SN 2175-5361
J9 REV PESQUI-CUID FUND
JI Rev. Pesqui.-Cuid. Fundam. Online
PY 2023
VL 15
AR 9
DI 10.5334/gh.1188
PG 15
WC Nursing
WE Emerging Sources Citation Index (ESCI)
SC Nursing
GA C8ST5
UT WOS:000964560000001
PM 36874442
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Pope, JE
   Choy, EH
AF Pope, Janet E.
   Choy, Ernest H.
TI C-reactive protein and implications in rheumatoid arthritis and
   associated comorbidities
SO SEMINARS IN ARTHRITIS AND RHEUMATISM
LA English
DT Article
ID INTERSTITIAL LUNG-DISEASE; MODIFYING ANTIRHEUMATIC DRUGS; ANTITUMOR
   NECROSIS FACTOR; ERYTHROCYTE SEDIMENTATION-RATE; OBSTRUCTIVE
   PULMONARY-DISEASE; ACTIVITY SCORE DAS28; SYSTEMIC-LUPUS-ERYTHEMATOSUS;
   SARILUMAB PLUS METHOTREXATE; PATIENT-REPORTED OUTCOMES; PHASE REACTANT
   LEVELS
AB C-reactive protein (CRP) is routinely assessed as a marker of systemic inflammation in rheumatoid arthritis (RA). However, it is also an immune regulator that plays an important role in inflammatory pathways associated with RA and promotes atherogenic effects. Comorbidities linked to systemic inflammation are common in RA, and CRP has been associated with the risk for cardiovascular disease, diabetes, metabolic syndrome, pulmonary diseases, and depression. The relationship between systemic inflammation, CRP, and comorbidities in RA is complex, and it is challenging to determine how changing CRP levels may affect the risk or progression of these comorbidities. We review the biological role of CRP in RA and its implications for disease activity and treatment response. We also discuss the impact of treatment on CRP levels and whether reducing systemic inflammation and inhibiting CRP-mediated inflammatory pathways may have an impact on conditions commonly comorbid with RA. (C) 2020 The Authors. Published by Elsevier Inc.
C1 [Pope, Janet E.] Univ Western Ontario, Schulich Sch Med, St Josephs Hlth Care, London, ON, Canada.
   [Choy, Ernest H.] Cardiff Univ, Div Infect & Immun, Sch Med, Cardiff, Wales.
C3 Western University (University of Western Ontario); University Western
   Ontario Hospital; Cardiff University
RP Choy, EH (corresponding author), Cardiff Univ, Div Infect & Immun, Sch Med, Cardiff, Wales.
EM ChoyEH@Cardiff.ac.uk
RI Pope, Janet/G-3342-2011
OI Pope, Janet/0000-0003-1479-5302
FU Sanofi Genzyme, Cambridge MA; Good Publications Practices (GPP3)
FX The authors received no payment or other compensation for developing
   this paper. Medical writing support, under the sole direction of the
   authors, was provided by Gregory Bezkorovainy (Adelphi Communications,
   Ltd, Macclesfield, UK) and was funded by Sanofi Genzyme, Cambridge MA in
   accordance with Good Publications Practices (GPP3).
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NR 219
TC 166
Z9 176
U1 2
U2 23
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0049-0172
EI 1532-866X
J9 SEMIN ARTHRITIS RHEU
JI Semin. Arthritis Rheum.
PD FEB
PY 2021
VL 51
IS 1
BP 219
EP 229
DI 10.1016/j.semarthrit.2020.11.005
PG 11
WC Rheumatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Rheumatology
GA QL2XA
UT WOS:000620943200025
PM 33385862
OA hybrid, Green Accepted
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Martin, SA
   Onajin, O
AF Martin, Sydney A.
   Onajin, Oluwakemi
TI Advancements in Comorbidity Screening and Multidisciplinary Symptom
   Management for Hidradenitis Suppurativa
SO CURRENT DERMATOLOGY REPORTS
LA English
DT Review
DE Hidradenitis Suppurativa; HS comorbidity; HS management; HS Screening;
   Multidisciplinary; Primary care
ID INFLAMMATORY-BOWEL-DISEASE; CORONARY-ARTERY-DISEASE; OBSTRUCTIVE
   SLEEP-APNEA; QUALITY-OF-LIFE; HEART-FAILURE; PREVALENCE; ASSOCIATION;
   DEPRESSION
AB Purpose of ReviewUnderstanding comorbidities associated with Hidradenitis Suppurativa (HS) is essential given their significant impact on overall health. This review employs an organ system-based framework to categorize comorbidities associated with HS, and highlights screening and multidisciplinary management based on recent data.Recent FindingsHistorically, many studies have demonstrated an increased prevalence of metabolic syndrome, inflammatory bowel disease, and mood disorders among patients with HS. More recent studies have also reported associations with asthma, chronic kidney disease, thyroid disease and sexual dysfunction. Moreover, novel treatment options for HS comorbid diseases, including diabetes and obesity, have shown promising results in the management of HS. This further supports the multisystemic implications of HS.SummaryHS and its comorbidities place a substantial burden on the healthcare system and often result in high morbidity and mortality. Dermatologists should be aware of comorbidities associated with HS and collaborate with physicians in other specialties for multidisciplinary management.
C1 [Martin, Sydney A.] Univ Illinois, Coll Med, Chicago, IL 60612 USA.
   [Onajin, Oluwakemi] Univ Chicago, Med Ctr, Dept Med, Sect Dermatol, 5841 S Maryland Ave,MC 5067, Chicago, IL 60637 USA.
C3 University of Illinois System; University of Illinois Chicago;
   University of Illinois Chicago Hospital; University of Chicago;
   University of Chicago Medical Center
RP Onajin, O (corresponding author), Univ Chicago, Med Ctr, Dept Med, Sect Dermatol, 5841 S Maryland Ave,MC 5067, Chicago, IL 60637 USA.
EM smart45@uic.edu; oonajin@bsd.uchicago.edu
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NR 84
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 2162-4933
J9 CURR DERMATOL REP
JI Curr. Dermatol. Rep.
PD DEC
PY 2024
VL 13
IS 4
BP 305
EP 314
DI 10.1007/s13671-024-00446-8
EA AUG 2024
PG 10
WC Dermatology
WE Emerging Sources Citation Index (ESCI)
SC Dermatology
GA I8E0T
UT WOS:001291238000001
DA 2025-06-11
ER

PT J
AU Rarick, JRD
   Dolan, CT
   Han, WJ
   Wen, J
AF Rarick, Jason R. D.
   Dolan, Carly Tubbs
   Han, Wen-Jui
   Wen, Jun
TI Relations Between Socioeconomic Status, Subjective Social Status, and
   Health in Shanghai, China
SO SOCIAL SCIENCE QUARTERLY
LA English
DT Article
ID MULTIPLE IMPUTATION; METABOLIC SYNDROME; ASSOCIATION; INEQUALITY; RISK;
   ADOLESCENTS; PERCEPTIONS; PREVALENCE; DEPRESSION
AB ObjectivesAlthough research has established a strong link between socioeconomic status (SES) and health in Western settings, comparable work in China lags behind. Similarly, studies showing a unique relationship for subjective social status (SSS) and health above and beyond SES have yet to be tested in China. The present study addresses these gaps.
   MethodsRegression analyses investigated the relationship between SES, SSS, and mental and physical health net of several covariates for 2,282 caregivers in Shanghai, China. Indirect relationships for SES through SSS were also tested.
   ResultsResults indicate that SES is linked to mental and physical health outcomes, but in complicated ways. SSS, on the other hand, is consistently and robustly linked to health outcomes above and beyond income, education, occupational prestige, and Hukou status. Further significant indirect effects were found through SSS for income, education, and Hukou status.
   ConclusionIn China's context of rapid economic growth, relationships to SES and health appear complicated. However, subjective perceptions of status are consistently linked to health outcomes.
C1 [Rarick, Jason R. D.; Dolan, Carly Tubbs; Han, Wen-Jui] NYU, New York, NY USA.
   [Wen, Jun] East China Normal Univ, Shanghai, Peoples R China.
C3 New York University; East China Normal University
RP Rarick, JRD (corresponding author), NYU, Steinhardt Sch Culture Educ & Human Dev, 246 Greene St,8th Floor, New York, NY 10003 USA.
EM jason.rarick@nyu.edu
RI Rarick, Jason/ABE-6122-2021; Han, Wen-Jui/ACU-6502-2022
FU NYU-ECNU Institute for Social Development at NYU Shanghai
FX The authors acknowledge the financial support from NYU-ECNU Institute
   for Social Development at NYU Shanghai in making the data collection and
   this research possible. We thank all participating school principals,
   teachers, parents, and children for their generosity in sharing their
   time and life with us, as well as the hardworking research team in
   making data collection possible. Jason R. D. Rarick will share all data
   and coding syntax for purposes of replication.
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NR 59
TC 23
Z9 23
U1 3
U2 43
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0038-4941
EI 1540-6237
J9 SOC SCI QUART
JI Soc. Sci. Q.
PD MAR
PY 2018
VL 99
IS 1
BP 390
EP 405
DI 10.1111/ssqu.12360
PG 16
WC Political Science; Sociology
WE Social Science Citation Index (SSCI)
SC Government & Law; Sociology
GA FV8UO
UT WOS:000424862700024
DA 2025-06-11
ER

PT J
AU Agustini, B
   Mohebbi, M
   Woods, RL
   McNeil, JJ
   Nelson, MR
   Shah, RC
   Murray, AM
   Ernst, ME
   Reid, CM
   Tonkin, A
   Lockery, JE
   Berk, M
AF Agustini, Bruno
   Mohebbi, Mohammadreza
   Woods, Robyn L.
   McNeil, John J.
   Nelson, Mark R.
   Shah, Raj C.
   Murray, Anne M.
   Ernst, Michael E.
   Reid, Christopher M.
   Tonkin, Andrew
   Lockery, Jessica E.
   Berk, Michael
CA ASPREE Investigator Grp
TI Association Between Statin Use and Depressive Symptoms in a Large
   Community-Dwelling Older Population Living in Australia and the USA: A
   Cross-Sectional Study
SO CNS DRUGS
LA English
DT Article
ID LATE-LIFE DEPRESSION; PRIMARY PREVENTION; METABOLIC SYNDROME; INCIDENT
   DEPRESSION; SHORT-FORM; ASPIRIN; ADULTS; RISK; METAANALYSIS; MEDICATIONS
AB BackgroundStatin use has been frequently associated with depressive symptoms in an older population. However, the nature of this association is uncertain in the literature. In this study, we aimed to investigate the association of statin intake and the prevalence of depressive symptoms in healthy community-dwelling older adults living in Australia and the USA.MethodsWe analysed baseline data from 19,114 participants, over 70years of age (over 65years of age, if from an ethnic minority). The association of self-reported statin use and prevalenceof depressive symptoms, as measured by a validated depression scale [Center for Epidemiological Studies Depression Scale (CES-D 10)], was determined using logistic regression models. Multivariable logistic models were implemented to account for important demographics and other lifestyle and socioeconomic factors, such as sex, age, living status, education and smoking history.ResultsA total of 5987 individuals were statin users. Of those, 633 (10.6%) had depressive symptoms (CES-D 10 cut-off >= 8), compared with 1246 (9.5%) of the non-statin users. In the unadjusted model, statin use was associated with an increase in prevalence of depressive symptoms (odds ratio 1.13, confidence interval 1.02-1.25, p=0.02). However, after adjusting for important demographic and socioeconomic factors, the use of statins was not significantly associated with depressive symptoms (odds ratio 1.09, confidence interval 0.98-1.20, p=0.11). In secondary analyses, only simvastatin was marginally associated with an increased prevalence of depressive symptoms. Statins were associated with a decreased prevalence of depressive symptoms in individuals with severe obesity (body mass index >35kg/m(2)) and an increased prevalence in participants between 75 and 84years of age.ConclusionThis study in a large community-dwelling older population did not show any association of statins with late-life depressive symptoms, after accounting for important socioeconomic and demographic factors. Confounding by indication is an important issue to be addressed in future pharmacoepidemiologic studies of statins.
C1 [Agustini, Bruno; Mohebbi, Mohammadreza; Berk, Michael] Deakin Univ, Sch Med, Innovat Mental & Phys Hlth & Clin Treatment Strat, IMPACT Strateg Res Ctr, POB 281, Geelong, Vic 3220, Australia.
   [Mohebbi, Mohammadreza] Deakin Univ, Biostat Unit, Geelong, Vic, Australia.
   [Woods, Robyn L.; McNeil, John J.; Reid, Christopher M.; Tonkin, Andrew; Lockery, Jessica E.] Monash Univ, Sch Publ Hlth & Prevent Med, Melbourne, Vic, Australia.
   [Nelson, Mark R.] Univ Tasmania, Menzies Inst Med Res, Hobart, Tas, Australia.
   [Shah, Raj C.] Rush Univ, Med Ctr, Dept Family Med, Chicago, IL USA.
   [Shah, Raj C.] Rush Univ, Med Ctr, Rush Alzheimers Dis Ctr, Chicago, IL USA.
   [Murray, Anne M.] Hennepin Healthcare, Hennepin Healthcare Res Inst, Berman Ctr Outcomes & Clin Res, Minneapolis, MN USA.
   [Ernst, Michael E.] Univ Iowa, Coll Pharm, Dept Pharm Practice & Sci, Iowa City, IA 52242 USA.
   [Ernst, Michael E.] Univ Iowa, Carver Coll Med, Dept Family Med, Iowa City, IA 52242 USA.
   [Reid, Christopher M.] Curtin Univ, Sch Publ Hlth, Perth, WA, Australia.
   [Berk, Michael] Natl Ctr Excellence Youth Hlth, Dept Psychiat, Orygen, Melbourne, Vic, Australia.
   [Berk, Michael] Florey Inst Neurosci & Mental Hlth, Melbourne, Vic, Australia.
   [Berk, Michael] Univ Melbourne, Melbourne, Vic, Australia.
C3 Deakin University; Deakin University; Monash University; University of
   Tasmania; Menzies Institute for Medical Research; Rush University; Rush
   University; University of Iowa; University of Iowa; Curtin University;
   Orygen, The National Centre of Excellence in Youth Mental Health; Florey
   Institute of Neuroscience & Mental Health; University of Melbourne
RP Agustini, B (corresponding author), Deakin Univ, Sch Med, Innovat Mental & Phys Hlth & Clin Treatment Strat, IMPACT Strateg Res Ctr, POB 281, Geelong, Vic 3220, Australia.
EM bagustini@deakin.edu.au
RI Shah, Raj/AAS-2210-2021; Ernst, Erika/O-5111-2019; McNeil,
   John/L-6440-2019; Berk, Michael/AGH-9427-2022; Woods, Robyn/K-8365-2016;
   Reid, Christopher/AAP-8135-2021; Berk, Michael/M-7891-2013
OI Agustini, Bruno/0000-0001-8735-2401; Ernst, Michael/0000-0003-0267-4888;
   Volpi, Elena/0000-0001-8776-0384; Reid, Christopher/0000-0001-9173-3944;
   McNeil, John/0000-0002-1049-5129; Lockery, Jessica
   Elisabeth/0000-0001-6664-1239; Woods, Robyn/0000-0003-1249-6149; Berk,
   Michael/0000-0002-5554-6946
FU National Institute on Aging; National Cancer Institute at the National
   Institutes of Health [U01AG029824]; National Health and Medical Research
   Council of Australia [334047, 1127060]; Monash University (Australia);
   Victorian Cancer Agency (Australia); National Health and Medical
   Research Council (NHMRC) Senior Principal Research Fellowship
   [APP1059660, APP1156072]; NHMRC Senior Research Fellowship [APP1045862]
FX The study is supported by the National Institute on Aging and the
   National Cancer Institute at the National Institutes of Health (Grant
   No. U01AG029824), the National Health and Medical Research Council of
   Australia (Grant Nos. 334047, 1127060), Monash University (Australia)
   and the Victorian Cancer Agency (Australia). Michael Berk is supported
   by a National Health and Medical Research Council (NHMRC) Senior
   Principal Research Fellowship (APP1059660 and APP1156072) and
   Christopher M. Reid is supported by a NHMRC Senior Research Fellowship
   (APP1045862).
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NR 49
TC 8
Z9 8
U1 0
U2 5
PU ADIS INT LTD
PI NORTHCOTE
PA 5 THE WAREHOUSE WAY, NORTHCOTE 0627, AUCKLAND, NEW ZEALAND
SN 1172-7047
EI 1179-1934
J9 CNS DRUGS
JI CNS Drugs
PD JUL
PY 2019
VL 33
IS 7
BP 685
EP 694
DI 10.1007/s40263-019-00633-3
PG 10
WC Clinical Neurology; Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA IJ0EO
UT WOS:000475573400006
PM 31062260
OA Green Submitted, Green Accepted
DA 2025-06-11
ER

PT J
AU Oladipo, OO
   Ayo, JO
   Ambali, SF
   Mohammed, B
   Aluwong, T
AF Oladipo, Olusola Olalekan
   Ayo, Joseph Olusegun
   Ambali, Suleiman Folorunsho
   Mohammed, Bisalla
   Aluwong, Tanang
TI Dyslipdemia induced by chronic low dose co-exposure to lead, cadmium and
   manganese in rats: the role of oxidative stress
SO ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
LA English
DT Article
DE Lead; cadmium; manganese; zinc; hypolipidaemia; oxidative stress
ID DENSITY-LIPOPROTEIN CHOLESTEROL; CARDIOVASCULAR-DISEASE; METABOLIC
   SYNDROME; RISK-FACTORS; PLASMA; ZINC; ASSOCIATION; HYPOCHOLESTEROLEMIA;
   TOXICITY; PROTECTS
AB Lead (Pb), cadmium (Cd) and manganese (Mn) have many potential adverse health effects in vitro and in animal models of clinical toxicity. The current study investigated the dyslipidaemic and oxidative stress effects of chronic low-dose oral exposure to Pb, Cd and Mn and the combination (Pb + Cd + Mn) in rats for 15 weeks. Chronic exposure to the metals did not significantly (P > 0.05) alter serum lipid profiles. However, the atherogenic index decreased by 32.2% in the Pb + Cd + Mn group, relative to the control. The triglyceride/high-density lipoprotein cholesterol ratio decreased by 39.4% in the Pb + Cd + Mn group, relative to the control, and elevated by 81.8, 94.8 and 20.8%, relative to the Pb, Cd and Mn groups, respectively. While the serum concentrations of malondialdehyde significantly increased in the Mn and Pb + Cd + Mn groups, that of glutathione peroxidase-1 decreased in the Pb + Cd + Mn group, and metallothionein-1 and zinc concentrations markedly decreased in all the metal treatment groups.
   The results suggest that long-term exposure of rats to Pb + Cd + Mn may result in hypolipidaemia, mediated via oxidative stress and metal interactions. Individuals who are constantly exposed to environmentally relevant levels of the metals may be at risk of hypolipidaemia.
C1 [Oladipo, Olusola Olalekan] Natl Inst Vet Res, Div Biochem, PMB 01, Vom, Nigeria.
   [Oladipo, Olusola Olalekan] Ahmadu Bello Univ, Dept Vet Pharmacol & Toxicol, Zaria, Nigeria.
   [Ayo, Joseph Olusegun; Aluwong, Tanang] Ahmadu Bello Univ, Dept Vet Physiol, Zaria, Nigeria.
   [Ambali, Suleiman Folorunsho] Univ Ilorin, Dept Vet Pharmacol & Toxicol, Ilorin, Nigeria.
   [Mohammed, Bisalla] Ahmadu Bello Univ, Dept Vet Pathol, Zaria, Nigeria.
C3 Ahmadu Bello University; Ahmadu Bello University; University of Ilorin;
   Ahmadu Bello University
RP Oladipo, OO (corresponding author), Natl Inst Vet Res, Div Biochem, PMB 01, Vom, Nigeria.; Oladipo, OO (corresponding author), Ahmadu Bello Univ, Dept Vet Pharmacol & Toxicol, Zaria, Nigeria.
EM oladiposola@ymail.com
RI Tagang, Aluwong/ABC-9678-2020; Oladipo, Olusola/H-5989-2019; Ambali,
   Suleiman/AHD-0164-2022
OI Ambali, Suleiman/0000-0002-5396-1468; Oladipo,
   Olusola/0000-0001-9498-1492
FU Africa Education Initiative (NEF), PA, U.S.A.; National Veterinary
   Research Institute, Vom, Nigeria
FX This work was supported in part, with a grant from the Africa Education
   Initiative (NEF), PA, U.S.A., and National Veterinary Research
   Institute, Vom, Nigeria.
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NR 62
TC 15
Z9 15
U1 1
U2 21
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1382-6689
EI 1872-7077
J9 ENVIRON TOXICOL PHAR
JI Environ. Toxicol. Pharmacol.
PD JUL
PY 2017
VL 53
BP 199
EP 205
DI 10.1016/j.etap.2017.06.017
PG 7
WC Environmental Sciences; Pharmacology & Pharmacy; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Pharmacology & Pharmacy; Toxicology
GA FC0ZC
UT WOS:000406566200025
PM 28654832
DA 2025-06-11
ER

PT J
AU Moon, JH
   Ryu, H
AF Moon, Ji Hyun
   Ryu, Hosihn
TI Salutogenesis intervention improves cardio-cerebrovascular health in
   at-risk office workers: A quasi-experimental study
SO PUBLIC HEALTH NURSING
LA English
DT Article
DE cardiovascular disease; health behavior; occupational health;
   occupational stress; sense of coherence
ID METABOLIC SYNDROME; COHERENCE; SENSE; BEHAVIOR; OBESITY; DISEASE;
   STRESS; MEN
AB ObjectiveCardio-cerebrovascular disease is the major cause of work-related deaths. Salutogenesis indicates individual differences in health levels occur owing to differences in the sense of coherence (SOC). A salutogenesis-based intervention may promote cardio-cerebrovascular health at work. This study examined the effects of a SOC promotion program based on salutogenesis.DesignQuasi-experimental study.SampleFifty-six office workers who were above the "low risk" of cardio-cerebrovascular disease from two workplaces were included in the final analysis.MeasurementsData collected pre- and postintervention. To determine the intervention's effectiveness, repeated-measures analysis of variance was used.InterventionThe intervention group was provided with the SOC promotion program, whereas the control group was provided with educational materials alone for 12 weeks.ResultsGeneralized resistance resources (GRRs; knowledge of cardio-cerebrovascular disease prevention, stress-coping strategies, and social support) and SOC significantly improved in the intervention group. The intervention group showed significant improvements in occupational stress, physical activity, dietary behavior, total cholesterol level, fasting glucose level, hemoglobin A1C level, body mass index, waist circumference, diastolic and systolic blood pressure, and cardio-cerebrovascular risk.ConclusionsSystematic salutogenesis-based SOC promotion programs should be established to enhance the cardio-cerebrovascular health of office workers at-risk of cardio-cerebrovascular diseases.Trial RegistrationTrial Registration Number is KCT0007029. The date of registration is February 23, 2022.
C1 [Moon, Ji Hyun] Sangmyung Univ, Dept Nursing, Cheonan, South Korea.
   [Ryu, Hosihn] Korea Univ, Coll Nursing, Seoul, South Korea.
   [Moon, Ji Hyun] Sangmyung Univ, Dept Nursing, 31 Sangmyeongdae Gil, Cheonan Si, Chungcheongnam, South Korea.
C3 Sangmyung University; Korea University; Sangmyung University
RP Moon, JH (corresponding author), Sangmyung Univ, Dept Nursing, 31 Sangmyeongdae Gil, Cheonan Si, Chungcheongnam, South Korea.
EM jhmoon222@smu.ac.kr
FU Hanmaum Scholarship of Seoul Nurses Association; Basic Science Research
   Program through the National Research Foundation (NRF) of Korea
   [2018R1D1A1B07044312]; Ministry of Education [2021R1I1A1A01042277];
   Korea University
FX Hanmaum Scholarship of Seoul Nurses Association in 2020; Basic Science
   Research Program through the National Research Foundation (NRF) of
   Korea, Grant/Award number: 2018R1D1A1B07044312; and Basic Science
   Research Program through the NRF of Korea funded by the Ministry of
   Education, Grant/Award number: 2021R1I1A1A01042277. This manuscript is a
   revision and modification of the first author's doctoral dissertation
   from Korea University. This paper is dedicated to Professor Hosihn Ryu,
   a deceased individual who has contributed to community health nursing
   development over the past decades. Additionally, the author would like
   to acknowledge the employees and manager of the enterprise who
   participated in the pretest or posttest.
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NR 50
TC 0
Z9 0
U1 1
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0737-1209
EI 1525-1446
J9 PUBLIC HEALTH NURS
JI Public Health Nurs.
PD JUL
PY 2024
VL 41
IS 4
BP 690
EP 703
DI 10.1111/phn.13331
EA MAY 2024
PG 14
WC Public, Environmental & Occupational Health; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; Nursing
GA YW0A3
UT WOS:001217369300001
PM 38702911
OA hybrid
DA 2025-06-11
ER

PT J
AU Angelico, F
   Alcantara-Payawal, D
   Rani, RA
   Mustafa, N
   Thongtang, N
   Chaiteerakij, R
   Bunchorntavakul, C
   Sukonthasarn, A
AF Angelico, Francesco
   Alcantara-Payawal, Diana
   Rani, Rafiz Abdul
   Mustafa, Norlaila
   Thongtang, Nuntakorn
   Chaiteerakij, Roongruedee
   Bunchorntavakul, Chalermrat
   Sukonthasarn, Apichard
TI Review and expert opinion on MAFLD, oxidative stress and multifunctional
   management
SO DRUGS IN CONTEXT
LA English
DT Review
DE epidemiology; expert opinion; metabolic-associated fatty-liver disease,;
   multidisciplinary care team; non-alcoholic fatty-liver disease;
   oxidative stress; patient journey
ID FATTY LIVER-DISEASE; QUALITY-OF-LIFE; PRACTICE GUIDANCE; CLINICAL
   BURDEN; SUPPLEMENTATION; METAANALYSIS; ASSOCIATION; PREVALENCE
AB Metabolic-associated fatty-liver disease (MAFLD), previously known as non-alcoholic fatty liver disease, is the most widespread and emerging chronic liver disease worldwide, with increasing prevalence rates also in the Asia-Pacific region. The disease has a high socio-economic burden as it negatively impacts the finances and quality of life of individuals affected and has a major burden on healthcare systems. The most important pathological event in MAFLD aetiopathogenesis is oxidative stress, which leads to functional and structural abnormalities in the liver as well as being involved in the development of other concomitant cardiometabolic diseases. MAFLD is a rather complex multisystemic clinical condition involving liver damage and a wide spectrum of extrahepatic manifestations such as obesity, type 2 diabetes, metabolic syndrome and cardiovascular diseases. This complexity requires the cooperation of multiple experts to identify MAFLD at an early stage, treat associated comorbidities, and promptly refer the patient to the hepatologist when needed. This review summarizes the current knowledge about MAFLD and reports the opinion of a group of experts on the increasing prevalence and burden of the disease in the southeast Asia region, the current journey of patients with MAFLD in developing countries, the role of oxidative stress and antioxidant treatment, and the importance of a multidisciplinary approach for early diagnosis and disease management.
C1 [Angelico, Francesco] Sapienza Univ, Dept Internal Med, Rome, Italy.
   [Alcantara-Payawal, Diana] Fatima Univ Med Ctr, Cardinal Santos Med Ctr, Dept Gastroenterol & Hepatol, Manila, Philippines.
   [Rani, Rafiz Abdul] Univ Teknol MARA, Fac Med, Dept Med, Gastroenterol Unit, Shah Alam, Selangor, Malaysia.
   [Mustafa, Norlaila] Univ Kebangsaan Malaysia, Dept Med, Kuala Lumpur, W Persekutuan, Malaysia.
   [Thongtang, Nuntakorn] Mahidol Univ, Fac Med, Dept Med, Div Endocrinol & Metab,Siriraj Hosp, Bangkok, Thailand.
   [Chaiteerakij, Roongruedee] Chulalongkorn Univ, Fac Med, Dept Med, Bangkok, Thailand.
   [Bunchorntavakul, Chalermrat] Rajavithi Hosp, Dept Gastroenterol, Bangkok, Thailand.
   [Sukonthasarn, Apichard] Chiang Mai Univ, Fac Med, Chiang Mai, Thailand.
C3 Sapienza University Rome; Universiti Teknologi MARA; Universiti
   Kebangsaan Malaysia; Mahidol University; Chulalongkorn University;
   Rajavithi Hospital; Chiang Mai University
RP Angelico, F (corresponding author), Sapienza Univ, Internal Med, Via Antonio Nibby 8, I-00161 Rome, Italy.
EM francesco.angelico@gmail.com
RI Mustafa, Norlaila/AAL-6310-2020; Abdul Rani, Rafiz/JEO-6921-2023;
   Wongpraparut, Nattawut/A-8031-2019
FU Viatris Inc.
FX Editorial assistance was provided by Ambra Corti, Francesca Cappellini,
   PhD, and Aashni Shah (Polistudium, Milan, Italy). This assistance was
   supported by Viatris Inc.
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NR 58
TC 8
Z9 8
U1 1
U2 5
PU BIOEXCEL PUBL LTD
PI HAYWARDS HEATH
PA  32, QUARRY HILL, HAYWARDS HEATH, WEST SUSSEX, ENGLAND
EI 1740-4398
J9 DRUGS CONTEXT
JI Drugs Context
PD JAN 10
PY 2024
VL 13
AR 202393
DI 10.7573/dic.2023-9-3
PG 11
WC Pharmacology & Pharmacy
WE Emerging Sources Citation Index (ESCI)
SC Pharmacology & Pharmacy
GA A1I0B
UT WOS:001280127100001
PM 38264403
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Yu, GR
   Lee, SJ
   Lim, DW
   Kim, H
   Kim, JE
   Park, WH
AF Yu, Ga-Ram
   Lee, Seung-Jun
   Lim, Dong-Woo
   Kim, Hyuck
   Kim, Jai-Eun
   Park, Won-Hwan
TI Drug Repurposing in Alternative Medicine: Sochehwan, a Polyherbal
   Traditional Korean Digestant, Protects against Alcoholic Steatohepatitis
   by Regulating Cytochrome P450 2E1 Expression
SO PROCESSES
LA English
DT Article
DE drug repurposing; Sochehwan; alcoholic liver injury; alcoholic liver
   disease; ER stress; MAPKs; inflammation; CYP2E1
ID FATTY LIVER-DISEASE; OXIDATIVE STRESS; ETHANOL; CYP2E1
AB Sochehwan (SCH) is an herbal prescription from traditional oriental medicine and is currently used to treat digestive ailments. In a previous study, SCH was found to have the potential to attenuate metabolic syndrome (MetS) by activating AMPK and downstream signaling. From the view of drug repurposing, the efficacy of SCH on alcoholic liver injury is implied in classic medical texts but is yet to be proven. C57BL/6J mice were pre-treated with SCH orally for 5 days and challenged by providing a pair-fed Lieber DeCarli diet containing alcohol for 20 days. Hepatic enzyme and triglyceride levels and endoplasmic reticulum (ER) stress-related markers were analyzed. Moreover, mitogen-activated protein kinases (MAPKs) and cytochrome P450 2E1 (CYP2E1) levels were determined. CYP2E1-transfected HepG2 cells were used to test the cytoprotective efficacy of SCH against the adverse effects of alcohol in vitro. In mice, SCH administration notably reduced hepatic enzyme activity and neural lipid levels. Furthermore, ER-stress markers and MAPK phosphorylation were reduced due to ROS suppression, which was attributed to decreased CYP2E1 expression in liver tissue. In addition, SCH successfully protected CYP2E1-transfected HepG2 cells against ethanol. Our findings suggest SCH attenuated alcohol-induced liver injury by inhibiting CYP2E1 expression and indicate drug repurposing should be considered as a valuable option for drug development in traditional herbal medicines.</p>
C1 [Yu, Ga-Ram; Lee, Seung-Jun; Lim, Dong-Woo; Kim, Hyuck; Park, Won-Hwan] Dongguk Univ, Coll Korean Med, Dept Diagnost, Dongguk Ro 32, Goyang 10326, South Korea.
   [Lim, Dong-Woo; Kim, Jai-Eun] Dongguk Univ, Coll Korean Med, Dept Pathol, Dongguk Ro 32, Goyang 10326, South Korea.
   [Kim, Hyuck] Dongguk Univ, Inst Korean Med, Dongguk Ro 32, Goyang 10326, South Korea.
C3 Dongguk University; Dongguk University; Dongguk University
RP Park, WH (corresponding author), Dongguk Univ, Coll Korean Med, Dept Diagnost, Dongguk Ro 32, Goyang 10326, South Korea.; Kim, JE (corresponding author), Dongguk Univ, Coll Korean Med, Dept Pathol, Dongguk Ro 32, Goyang 10326, South Korea.
EM herbqueen@dongguk.ac.kr
RI Lim, Dongwoo/GLU-0640-2022; Kim, Seung-Nam/KGL-6270-2024
OI Yu, Ga-Ram/0000-0003-1559-4326; Lim, Dongwoo/0000-0002-3179-9439
FU Basic Science Research Program through the National Research Foundation
   of Korea by the Ministry of Science and ICT [NRF-2019R1F1A1051652]
FX This work was supported by the Basic Science Research Program through
   the National Research Foundation of Korea by the Ministry of Science and
   ICT (NRF-2019R1F1A1051652).
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NR 38
TC 0
Z9 0
U1 0
U2 4
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2227-9717
J9 PROCESSES
JI Processes
PD OCT
PY 2021
VL 9
IS 10
AR 1760
DI 10.3390/pr9101760
PG 12
WC Engineering, Chemical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering
GA WO9XL
UT WOS:000712797600001
OA gold
DA 2025-06-11
ER

PT J
AU Miyata, T
   Dan, T
AF Miyata, Toshio
   Dan, Takashi
TI Inhibition of advanced glycation end products (AGEs): An implicit goal
   in clinical medicine for the treatment of diabetic nephropathy?
SO DIABETES RESEARCH AND CLINICAL PRACTICE
LA English
DT Article; Proceedings Paper
CT International Symposium on Diabetic Nephropathy
CY 2008
CL Shiga, JAPAN
DE Blood pressure; Renin-angiotensin system; Oxidative stress; Advanced
   glycation; Chronic hypoxia
ID RECEPTOR BLOCKERS; MEGSIN; INJURY; OVEREXPRESSION; INSULIN; STRESS;
   DAMAGE; MODEL
AB Several factors are incriminated in the genesis of diabetic nephropathy (DN). To elucidate their interplays, we utilized a diabetic rat model with nephropathy (SHR/NDmcr-cp). This model is characterized by hypertension, obesity with the metabolic syndrome, diabetes with insulin resistance, and intrarenal AGE accumulation. Various therapeutic approaches were used to achieve renoprotection. Caloric restriction corrects metabolic abnormalities and protects the kidney without correcting hypertension. Anti-hypertensive agents, angiotensin II receptor blocker (ARB) and calcium channel blocker, lower blood pressure to the same extent, but only ARBs protect the kidney without changes in metabolic abnormalities. Glycemic control is better with insulin than with pioglitazone. The plasma insulin level is increased by insulin but decreased by pioglitazone which worsens the obesity. Nevertheless, pioglitazone provides renoprotection unlike insulin, perhaps as a result of the up-regulation of TGF-beta by hyperinsulinemia. Cobalt up-regulates the expression of a hypoxia-inducible factor (HIF) and its downstream genes (erythropoietin, VEGF, HO-1). It protects the kidney without correcting hypertension and metabolic abnormalities. Altogether, renoprotection is not necessarily associated with blood pressure or glycemic control, By contrast, it is almost always associated with a decreased AGE formation. AGE reduction may reflect a decreased oxidative stress as it is concomitant with a marked reduction of oxidative stress markers. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
C1 [Miyata, Toshio; Dan, Takashi] Tohoku Univ, Grad Sch Med, Ctr Translat & Adv Res, Aoba Ku, Sendai, Miyagi 9808575, Japan.
C3 Tohoku University
RP Miyata, T (corresponding author), Tohoku Univ, Grad Sch Med, Ctr Translat & Adv Res, Aoba Ku, 2-1 Seiryo Machi, Sendai, Miyagi 9808575, Japan.
EM t-miyata@mail.tains.tohoku.ac.jp
RI Miyata, Toshio/A-4872-2010
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NR 21
TC 17
Z9 19
U1 0
U2 1
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0168-8227
EI 1872-8227
J9 DIABETES RES CLIN PR
JI Diabetes Res. Clin. Pract.
PD NOV 13
PY 2008
VL 82
SU 1
BP S25
EP S29
DI 10.1016/j.diabres.2008.09.012
PG 5
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Endocrinology & Metabolism
GA 381RM
UT WOS:000261553600006
PM 18954918
DA 2025-06-11
ER

PT J
AU Yang, JP
   Shin, JH
   Seo, SH
   Kim, SG
   Lee, SH
   Shin, EH
AF Yang, Jung-Pyo
   Shin, Ji-Hun
   Seo, Seung-Hwan
   Kim, Sang-Gyun
   Lee, Sang Hyung
   Shin, Eun-Hee
TI Effects of Antioxidants in Reducing Accumulation of Fat in Hepatocyte
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE vitamin C; N-acetyl-L-cysteine; astaxanthin; oleic acid; free radical
   scavenging; lipogenesis
ID LIVER-DISEASE; OXIDATIVE STRESS; N-ACETYLCYSTEINE; METABOLIC SYNDROME;
   REACTIVE OXYGEN; ASTAXANTHIN; INFLAMMATION; MECHANISMS; ACID
AB The progress of the hepatic steatosis (HS), a clinicopathological status, is influenced by cellular oxidative stress, lipogenesis, fatty acid (FA) oxidation, and inflammatory responses. Because antioxidants are gaining attention as potent preventive agents for HS, we aimed to investigate anti-lipogenic effects of the antioxidants vitamin C (VC), N-acetylcysteine (NAC), and astaxanthin (ATX) using hepatocytes. For this, we established an in vitro model using 1 mM oleic acid (OA) and human liver hepatocellular carcinoma (HepG2) cells; 10 mu M antioxidants were evaluated for their ability to reduce fat accumulation in hepatocytes. Our results showed that all three antioxidants were effective to reduce fat accumulation for the molecular targets such as reduction in lipid droplets, triglyceride (TG) concentration, reactive oxygen species (ROS) production, and cell apoptosis, as well as in gene expressions of endoplasmic reticulum (ER) stress-related effectors, lipogenesis, and inflammatory cytokines. There were simultaneous increases in diphenyl-1-picrylhydrazyl (DPPH) radical scavenging effect, cell survival, AMPK phosphorylation, NRF2-related gene expression for cellular defense, and FA fi -oxidation. However, among these, ATX more effectively inhibited ER stress and lipogenesis at the intracellular level than VC or NAC. Consequently, ATX was also more effective in inhibiting cell death, lipotoxicity, and inflammation. Our result emphasizes that ATX achieved greater lipotoxicity reduction than VC and NAC.
C1 [Yang, Jung-Pyo; Shin, Ji-Hun; Seo, Seung-Hwan; Kim, Sang-Gyun; Shin, Eun-Hee] Seoul Natl Univ, Coll Med, Dept Parasitol & Trop Med, Seoul 03080, South Korea.
   [Yang, Jung-Pyo; Shin, Ji-Hun; Seo, Seung-Hwan; Kim, Sang-Gyun; Shin, Eun-Hee] Inst Endem Dis, Seoul 03080, South Korea.
   [Lee, Sang Hyung] Seoul Natl Univ, Coll Med, SMG SNU Boramae Med Ctr, Dept Neurosurg, Seoul 07061, South Korea.
   [Shin, Eun-Hee] Seoul Natl Univ, Bundang Hosp, Seongnam 13620, South Korea.
C3 Seoul National University (SNU); Seoul National University (SNU); Seoul
   National University Hospital; Seoul National University (SNU)
RP Shin, EH (corresponding author), Seoul Natl Univ, Coll Med, Dept Parasitol & Trop Med, Seoul 03080, South Korea.; Shin, EH (corresponding author), Inst Endem Dis, Seoul 03080, South Korea.; Shin, EH (corresponding author), Seoul Natl Univ, Bundang Hosp, Seongnam 13620, South Korea.
EM fellnim@naver.com; charisma4395@naver.com; stopsh23@naver.com;
   0949kim@hanmail.net; nslee@snu.ac.kr; ehshin@snu.ac.kr
RI SHIN, JIHUN/KZU-9038-2024; Kim, Sang/J-5398-2012; Shin,
   Eun-Hee/D-5757-2012
OI Shin, Eun-Hee/0000-0003-1215-1079; Yang, Jung-Pyo/0000-0002-7439-4095;
   Shin, Ji-Hun/0000-0003-1505-6560
FU foundation of Sunchang-gun health and longevity research institute
   [0564-20160008]
FX This work was supported by grants from foundation of Sunchang-gun health
   and longevity research institute (0564-20160008).
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NR 37
TC 42
Z9 51
U1 0
U2 23
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD SEP
PY 2018
VL 19
IS 9
AR 2563
DI 10.3390/ijms19092563
PG 17
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA HA1OU
UT WOS:000449988100099
PM 30158441
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Hanafi, MY
   Abdelkhalek, TM
   Saad, MI
   Saleh, MM
   Haiba, MM
   Kamel, MA
AF Hanafi, Mervat Y.
   Abdelkhalek, Taha M.
   Saad, Mohamed I.
   Saleh, Moustafa M.
   Haiba, Maha M.
   Kamel, Maher A.
TI Diabetes-induced perturbations are subject to intergenerational
   transmission through maternal line
SO JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
LA English
DT Article
DE Diabetes; Fetal programming; Fetal origin of disease; Glucose sensing;
   Oxidative stress
ID MITOCHONDRIAL-TRANSCRIPTION-FACTOR; PANCREATIC BETA-CELLS;
   INSULIN-RESISTANCE; GENE-EXPRESSION; GENDER-DIFFERENCES; OXIDATIVE
   STRESS; UP-REGULATION; BIRTH-WEIGHT; GLUCOSE; SENSITIVITY
AB The hypothesis of fetal origins of adult disease states that early life events program the occurrence of significant adult diseases, including diabetes and obesity. Maternal diabetes is associated with general stress environment for developing fetus, and gestational diabetes is an independent risk factor for type 2 diabetes and metabolic syndrome in offspring. Intra-uterine fetal programming of fetal tissues exposes the offspring to increased risk of impaired glucose tolerance, type 2 diabetes, and cardiovascular disease. Here, we examined the transmission of maternal diabetes-induced fetal programming in second generation and compared maternal and paternal routes of intergenerational effects. We organized 40 Wistar rats into three groups, male offspring of diabetic mothers, female offspring of diabetic mothers, and offspring of control mothers. These groups were mated with normal healthy rats to assess the effect of grand-maternal diabetes on pregnancy outcome in F2 rats, as well as glucose-sensing parameters, insulin resistance, and glucose tolerance prenatally and postnatally. We found that F2 offspring of diabetic mothers had impaired glucose sensing, increased oxidative stress, insulin resistance, and impaired glucose tolerance, and these effects were more prominent in the F2 offspring of F1 female rats (F2-DF1F). We deduce that fetal programming of maternal diabetes is mostly transmitted through maternal line across two generations.
C1 [Hanafi, Mervat Y.; Saad, Mohamed I.; Haiba, Maha M.; Kamel, Maher A.] Univ Alexandria, Med Res Inst, Dept Biochem, 165 Elhorreya,Ave,POB 21561, Alexandria, Egypt.
   [Abdelkhalek, Taha M.; Saleh, Moustafa M.] Univ Alexandria, Med Res Inst, Dept Human Genet, Alexandria, Egypt.
   [Saad, Mohamed I.] Monash Univ, Hudson Inst Med Res, Ritchie Ctr, Melbourne, Vic 3004, Australia.
C3 Egyptian Knowledge Bank (EKB); Alexandria University; Egyptian Knowledge
   Bank (EKB); Alexandria University; Hudson Institute of Medical Research;
   Monash University
RP Saad, MI (corresponding author), Monash Univ, Hudson Inst Med Res, Ritchie Ctr, Melbourne, Vic 3004, Australia.
EM m.ibrahim1988@hotmail.com
RI Kamel, Maher/S-2397-2019; Saad, Mohamed/AAE-8887-2019
OI Kamel, Maher/0000-0002-6791-9850; Saleh, Moustafa/0000-0002-6531-5711;
   Saad, Mohamed I./0000-0002-4855-2360
FU Science and Technology Development Fund (STDF)-Egypt
FX This study is a part of project entitled "Intra-Uterine programming of
   adult diabetes: an experimental study" supported by the Science and
   Technology Development Fund (STDF)-Egypt.
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NR 41
TC 11
Z9 12
U1 0
U2 7
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1138-7548
EI 1877-8755
J9 J PHYSIOL BIOCHEM
JI J. Physiol. Biochem.
PD JUN
PY 2016
VL 72
IS 2
BP 315
EP 326
DI 10.1007/s13105-016-0483-7
PG 12
WC Biochemistry & Molecular Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Physiology
GA DM6RF
UT WOS:000376479400016
PM 27038466
DA 2025-06-11
ER

PT J
AU Putakala, M
   Gujjala, S
   Nukala, S
   Desireddy, S
AF Putakala, Mallaiah
   Gujjala, Sudhakara
   Nukala, Srinivasulu
   Desireddy, Saralakumari
TI Beneficial Effects of Phyllanthus amarus Against High Fructose
   Diet Induced Insulin Resistance and Hepatic Oxidative Stress in Male
   Wistar Rats
SO APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
LA English
DT Article
DE Insulin resistance; High-fructose diet; Oxidative stress; Oral glucose
   tolerance test; Phyllanthus amarus
ID AQUEOUS EXTRACT; SEED EXTRACT; LIVER-DAMAGE; GALLIC ACID; PPAR-GAMMA;
   SENSITIVITY; STREPTOZOTOCIN; DYSLIPIDEMIA; ADIPOSITY; PATHWAYS
AB Insulin resistance (IR) is a characteristic feature of obesity, type 2 diabetes mellitus, and cardiovascular diseases. Emerging evidence suggests that the high-fructose consumption is a potential and important factor responsible for the rising incidence of IR. The present study investigates the beneficial effects of aqueous extract of Phyllanthus amarus (PAAE) on IR and oxidative stress in high-fructose (HF) fed male Wistar rats. HF diet (66% of fructose) and PAAE (200 mg/kg body weight/day) were given concurrently to the rats for a period of 60 days. Fructose-fed rats showed weight gain, hyperglycemia, hyperinsulinemia, impaired glucose tolerance, impaired insulin sensitivity, dyslipidemia, hyperleptinemia, and hypoadiponectinemia (P < 0.05) after 60 days. Co-administration of PAAE along with HF diet significantly ameliorated all these alterations. Regarding hepatic antioxidant status, higher lipid peroxidation and protein oxidation, lower reduced glutathione levels and lower activities of enzymatic antioxidants, and the histopathological changes like mild to severe distortion of the normal architecture as well as the prominence and widening of the liver sinusoids observed in the HF diet-fed rats were significantly prevented by PAAE treatment. These findings indicate that PAAE is beneficial in improving insulin sensitivity and attenuating metabolic syndrome and hepatic oxidative stress in fructose-fed rats.
C1 [Putakala, Mallaiah; Gujjala, Sudhakara; Nukala, Srinivasulu; Desireddy, Saralakumari] Sri Krishnadevaraya Univ, Dept Biochem, Anantapuramu 515003, Andhra Pradesh, India.
C3 Sri Krishnadevaraya University
RP Desireddy, S (corresponding author), Sri Krishnadevaraya Univ, Dept Biochem, Anantapuramu 515003, Andhra Pradesh, India.
EM skumari1@yahoo.co.in
FU University Grant Commission, New Delhi, India [F.4-3/2007
   (BSR)/11-59/2007 (BSR)]
FX This work was supported by grants from the University Grant Commission,
   New Delhi, India (F.4-3/2007 (BSR)/11-59/2007 (BSR). Thanks are also due
   to Dr. Ch. Appa Rao and Mr. K. Vinay Kumar, Sri Venkateswara University,
   Tirupati, AP, India, and Prof. B. Sashidhar Rao and Dr. G. Kavitha,
   Osmania University, Hyderabad, AP, India, for providing lab facility,
   Mr. R. Rajendran, Green Chem Herbal Extract and Formulations, Bangalore,
   for HPLC analysis, Prof. P. Md. Akthar, Department of Statistics, S.K.
   University for statistical analysis, and Prof. P.B.B.N. Charyulu,
   Department of Microbiology (Rtd), S.K. University Anantapuramu, AP,
   India, for proofreading of this article.
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NR 67
TC 15
Z9 16
U1 0
U2 6
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0273-2289
EI 1559-0291
J9 APPL BIOCHEM BIOTECH
JI Appl. Biochem. Biotechnol.
PD NOV
PY 2017
VL 183
IS 3
BP 744
EP 764
DI 10.1007/s12010-017-2461-0
PG 21
WC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology
GA FL4JG
UT WOS:000414195200005
PM 28353042
DA 2025-06-11
ER

PT J
AU Garcia-Diaz, DF
   Lopez-Legarrea, P
   Quintero, P
   Martinez, JA
AF Fernando Garcia-Diaz, Diego
   Lopez-Legarrea, Patricia
   Quintero, Pablo
   Alfredo Martinez, Jose
TI Vitamin C in the Treatment and/or Prevention of Obesity
SO JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY
LA English
DT Review
DE ascorbic acid; antioxidant; body weight; oxidative stress
ID WHITE ADIPOSE-TISSUE; TOTAL ANTIOXIDANT CAPACITY; INDUCED OXIDANT
   STRESS; KAPPA-B ACTIVATION; ASCORBIC-ACID; OXIDATIVE STRESS;
   GENE-EXPRESSION; METABOLIC SYNDROME; INSULIN-RESISTANCE;
   PHYSIOLOGICAL-ROLE
AB Obesity has emerged as one of the major health threats worldwide. Moreover, an excessive body fat accumulation, which defines this disease, could lead to several associated clinical manifestations such as cardiovascular events, type 2 diabetes, inflammation, and some types of cancer. The appearance of these co-morbidities has been often related to an unbalanced oxidative stress. Therefore, antioxidant-based treatments could be considered as interesting approaches to possibly counteract obesity fat accumulation complications. In this context, it has been observed that vitamin C intake (ascorbic acid) is negatively associated with the occurrence of several conditions such as hypertension, gallbladder disease, stroke, cancers, and atherosclerosis, and also with the onset of obesity in humans and animals. Among the possible beneficial effects of ascorbic acid on obesity-related mechanisms, it has been suggested that this vitamin may: (a) modulate adipocyte lipolysis; (b) regulate the glucocorticoid release from adrenal glands; (c) inhibit glucose metabolism and leptin secretion on isolated adipocytes; (d) lead to an improvement in hyperglycemia and decrease glycosylation in obese-diabetic models; and (e) reduce the inflammatory response. Possibly, all these features could be related with the outstanding antioxidant characteristics of this vitamin. Thus, the present article reviews the up-to-date evidence regarding in vitro and in vivo effects of vitamin C in obesity and its co-morbidities.
C1 [Fernando Garcia-Diaz, Diego] Univ Chile, Dept Nutr, Santiago, Chile.
   [Lopez-Legarrea, Patricia] Univ Autonoma Chile, Fac Hlth Sci, Santiago, Chile.
   [Quintero, Pablo] Pontificia Univ Catolica Chile, Sch Med, Dept Gastroenterol, Santiago, Chile.
   [Alfredo Martinez, Jose] Univ Navarra, Dept Food Sci & Physiol, E-31080 Pamplona, Spain.
   [Alfredo Martinez, Jose] Inst Salud Carlos III, CIBERobn Fisiopatol Obesidad & Nutr, Madrid, Spain.
C3 Universidad de Chile; Universidad Autonoma de Chile; Pontificia
   Universidad Catolica de Chile; University of Navarra; CIBER - Centro de
   Investigacion Biomedica en Red; CIBEROBN; Instituto de Salud Carlos III
RP Martinez, JA (corresponding author), Univ Navarra, Dept Food Sci & Physiol, E-31080 Pamplona, Spain.
EM jalfmtz@unav.es
RI Garcia, Diego/AGH-4056-2022; Martinez Hernandez, J Alfredo/K-8709-2014
OI Martinez Hernandez, J Alfredo/0000-0001-5218-6941; Garcia-Diaz,
   Diego/0000-0002-7551-0553
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NR 111
TC 73
Z9 76
U1 1
U2 38
PU CENTER ACADEMIC PUBL JAPAN
PI TOKYO
PA 2-4-16 YAYOI, BUNKYO-KU, TOKYO, 113-0032, JAPAN
SN 0301-4800
EI 1881-7742
J9 J NUTR SCI VITAMINOL
JI J. Nutr. Sci. Vitaminol.
PD DEC
PY 2014
VL 60
IS 6
BP 367
EP 379
DI 10.3177/jnsv.60.367
PG 13
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA AY1OB
UT WOS:000347361100001
PM 25866299
OA gold
DA 2025-06-11
ER

PT J
AU Barroso, OM
   Menéndez, IMG
   Castro, LV
   Valladares, EJB
AF Barroso, Omar Morejon
   Menendez, Imandra Maria Garcia
   Castro, Leticia Varela
   Valladares, Ernesto Julio Bernal
TI Rectal Application of Ozone to Patients with Diabetes Mellitus
SO FINLAY
LA English
DT Article
DE diabetes mellitus; oxidative stress; metabolic syndrome
ID OXIDATIVE STRESS
AB Background: patients with diabetes mellitus have a significant increase in oxidative stress, where there is a decrease in the activity of antioxidant systems and an increase in oxidation products. Ozone acts by inducing moderate oxidative stress and stimulating an enzymatic antioxidant defense.Objective: to characterize the metabolic control of diabetic patients at the beginning and at the end of rectal ozone therapy. Methods: a quasi-experimental study was carried out with pre and post therapy, where the universe consisted of 121 diabetic patients from the family doctor's office, number 15 of the Jose Luis Chaviano Community Teaching Polyclinic in Cienfuegos, applying rectal ozone therapy prior medical evaluation for 15 sessions twice a year. Demographic variables were collected: age and sex; clinics: hemochemical parameters, time of evolution of the disease and nutritional status; as neurovascular complications: diabetic foot, diabetic polyneuropathy and diabetic retinopathy; treatments: hypoglycemic; modifiable risk factors: arterial hypertension, diabetes mellitus, smoking, alcoholism, physical exercise; calculation of body mass index. The results found were expressed mainly through tables and graphs as the main resources of the statistical language.Results: patients with type 2 diabetes mellitus predominated with 95.0 %. There was a 2,769 mmol/L decrease in blood glucose levels after treatment with rectal ozone, which shows metabolic control. Conclusions: rectal ozone therapy can be used as a complementary therapy to the conventional treatment of patients with diabetes mellitus, since it improves glycemia parameters.
C1 [Barroso, Omar Morejon; Castro, Leticia Varela; Valladares, Ernesto Julio Bernal] Hosp Gen Univ Dr Gustavo Aldereguia Lima, Cienfuegos, Cuba.
   [Menendez, Imandra Maria Garcia] Policlin Comunitario Docente Jose Luis Chaviano, Cienfuegos, Cuba.
RP Barroso, OM (corresponding author), Hosp Gen Univ Dr Gustavo Aldereguia Lima, Cienfuegos, Cuba.
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NR 17
TC 0
Z9 0
U1 0
U2 0
PU CENTRO PROVINCIAL INFORMACION CIENCIAS MEDICAS CINFUEGOS
PI CINFUEGOS
PA CALLE 51 A & AVENIDA 5 SEPTIEMBRE, CINFUEGOS, 55100, CUBA
SN 2221-2434
J9 FINLAY
JI Finlay
PD FEB
PY 2023
VL 13
IS 1
BP 1
EP 7
PG 7
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA 9F2PS
UT WOS:000937316200001
DA 2025-06-11
ER

PT J
AU van Bree, BWJ
   Lenaers, E
   Nabben, M
   Briedé, JJ
   Jörgensen, JA
   Schaart, G
   Schrauwen, P
   Hoeks, J
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AF van Bree, Bianca W. J.
   Lenaers, Ellen
   Nabben, Miranda
   Briede, Jacco J.
   Jorgensen, Johanna A.
   Schaart, Gert
   Schrauwen, Patrick
   Hoeks, Joris
   Hesselink, Matthijs K. C.
TI A genistein-enriched diet neither improves skeletal muscle oxidative
   capacity nor prevents the transition towards advanced insulin resistance
   in ZDF rats
SO SCIENTIFIC REPORTS
LA English
DT Article
ID MITOCHONDRIAL-FUNCTION; UNCOUPLING PROTEIN-3; SOY PROTEIN; METABOLIC
   SYNDROME; ROS PRODUCTION; ENZYME-ACTIVITIES; ISOFLAVONES; OBESE;
   GLUCOSE; STRESS
AB Genistein, a natural food compound mainly present in soybeans, is considered a potent antioxidant and to improve glucose homeostasis. However, its mechanism of action remains poorly understood. Here, we analyzed whether genistein could antagonize the progression of the hyperinsulinemic normoglycemic state (pre-diabetes) toward full-blown T2DM in Zucker Diabetic Fatty (ZDF) rats by decreasing mitochondrial oxidative stress and improving skeletal muscle oxidative capacity. Rats were assigned to three groups: (1) lean control (CNTL), (2) fa/fa CNTL, and (3) fa/fa genistein (GEN). GEN animals were subjected to a 0.02% (w/w) genistein-enriched diet for 8 weeks, whereas CNTL rats received a standard diet. We show that genistein did not affect the overall response to a glucose challenge in ZDF rats. In fact, genistein may exacerbate glucose intolerance as fasting glucose levels were significantly higher in fa/fa GEN (17.6 +/- 0.7 mM) compared with fa/fa CNTL animals (14.9 +/- 1.4 mM). Oxidative stress, established by electron spin resonance (ESR) spectroscopy, carbonylated protein content and UCP3 levels, remained unchanged upon dietary genistein supplementation. Furthermore, respirometry measurements revealed no effects of genistein on mitochondrial function. In conclusion, dietary genistein supplementation did not improve glucose homeostasis, alleviate oxidative stress, or augment skeletal muscle metabolism in ZDF rats.
C1 [van Bree, Bianca W. J.; Nabben, Miranda; Jorgensen, Johanna A.; Schrauwen, Patrick; Hoeks, Joris] Maastricht Univ, NUTRIM Sch Nutr Toxicol & Metab, Dept Human Biol, NL-6200 MD Maastricht, Netherlands.
   [Lenaers, Ellen; Jorgensen, Johanna A.; Schaart, Gert; Hesselink, Matthijs K. C.] Maastricht Univ, Dept Human Movement Sci, NUTRIM Sch Nutr Toxicol & Metab, NL-6200 MD Maastricht, Netherlands.
   [Briede, Jacco J.] Maastricht Univ, Dept Toxicogen, GROW Sch Oncol & Dev Biol, NL-6200 MD Maastricht, Netherlands.
C3 Maastricht University; Maastricht University Medical Centre (MUMC);
   Maastricht University; Maastricht University Medical Centre (MUMC);
   Maastricht University
RP Hesselink, MKC (corresponding author), Maastricht Univ, Dept Human Movement Sci, NUTRIM Sch Nutr Toxicol & Metab, NL-6200 MD Maastricht, Netherlands.
EM matthijs.hesselink@maastrichtuniversity.nl
RI Nabben, Miranda/JGD-5231-2023; schrauwen, patrick/KRR-1274-2024
OI Nabben, Miranda/0000-0002-5691-1634; schrauwen,
   patrick/0000-0002-0973-847X; Briede, Jacco/0000-0003-1405-5232; Hoeks,
   Joris/0000-0002-0265-0870
FU School of Life Sciences; VIDI grants for innovative research from the
   Netherlands Organization for scientific Research [917.66.359,
   917.14.358]
FX The work of E. Lenaers has been supported by a grant from the School of
   Life Sciences, Dr. M.K.C. Hesselink (917.66.359) and Dr. J. Hoeks
   (917.14.358) were supported by VIDI grants for innovative research from
   the Netherlands Organization for scientific Research.
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NR 56
TC 8
Z9 9
U1 0
U2 10
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD MAR 14
PY 2016
VL 6
AR 22854
DI 10.1038/srep22854
PG 10
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA DG2DB
UT WOS:000371875300001
PM 26973284
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Reid, BM
   Sokol, N
   Aubuchon-Endsley, NL
   Stroud, LR
AF Reid, Brie M.
   Sokol, Natasha
   Aubuchon-Endsley, Nicki L.
   Stroud, Laura R.
TI Maternal prenatal cortisol and the interaction of income and
   pre-pregnancy body mass index are independently associated with newborn
   cortisol
SO DEVELOPMENTAL PSYCHOBIOLOGY
LA English
DT Article
DE cortisol; income; newborn; pregnancy; stress; weight
ID PITUITARY-ADRENAL AXIS; FOOD INSECURITY; AWAKENING RESPONSE; METABOLIC
   SYNDROME; SALIVARY CORTISOL; STRESS RESPONSES; INFANT CORTISOL; HPA
   AXIS; PREGNANCY; OBESITY
AB While extensive research has supported the developmental programming hypothesis regarding contributions of prenatal psychosocial or nutritional adversity to offspring stress physiology, fewer studies consider both exposures together with maternal stress physiology. This study examined newborn cortisol output during a stressor as a function of maternal pre-pregnancy health status and nutritional history (pre-pregnancy body mass index [PPBMI]), economic resources (household income), and maternal cortisol awakening response (mCAR) in late pregnancy. Participants were 102 mother-infant pairs from an economically and racial/ethnically diverse sample. Offspring salivary cortisol response to a neurobehavioral exam was assessed at 1 month. Income and maternal PPBMI were positively associated with mCAR in late pregnancy. mCAR was positively related to 1-month newborn cortisol response. The interaction of income and PPBMI was positively associated with newborn cortisol output during an exam at 1-month. Mothers with the highest PPBMI and lowest income had offspring with higher cortisol responses than offspring of mothers with higher income and lower PPBMI. There was no evidence of indirect mediation effects of predictors (PPBMI, income, and interaction) on infant cortisol via mCAR. The differential effects of the interaction of PPBMI and income suggest that these exposures influence infant cortisol output in the context of one another, independent of maternal pregnancy cortisol.
C1 [Reid, Brie M.; Sokol, Natasha; Stroud, Laura R.] Brown Univ, Warren Alpert Med Sch, Dept Psychiat & Human Behav, Providence, RI 02912 USA.
   [Reid, Brie M.; Sokol, Natasha; Stroud, Laura R.] Miriam Hosp, Ctr Behav & Prevent Med, Providence, RI USA.
   [Aubuchon-Endsley, Nicki L.] Univ Tulsa, Dept Psychol, Tulsa, OK USA.
C3 Brown University; Lifespan Health Rhode Island; Miriam Hospital;
   University of Tulsa
RP Reid, BM; Stroud, LR (corresponding author), Brown Univ, Warren Alpert Med Sch, Dept Psychiat & Human Behav, Providence, RI 02912 USA.
EM brie_reid@brown.edu; laura_stroud@brown.edu
RI Stroud, Laura/O-7807-2019; Aubuchon-Endsley, Nicki/Y-8061-2019; Reid,
   Brie/ABC-9782-2020
OI Stroud, Laura/0000-0002-2138-968X
FU National Institute of Mental Health [R01MH079153]; National Institute on
   Drug Abuse [K01DA054324]; National Institute of General Medical Sciences
   [1P20GM139767]; Eunice Kennedy Shriver National Institute of Child
   Health and Human Development [T32HD101392]; National Institute on
   Alcohol Abuse and Alcoholism [T32AA007459]
FX We express our gratitude to the families who made our research possible.
   This research was supported by grants from the National Institute of
   Mental Health [R01MH079153], National Institute on Drug Abuse
   [5R01DA044504], and the National Institute of General Medical Sciences
   [1P20GM139767] to Laura R. Stroud. Brie M. Reid was supported by the
   Eunice Kennedy Shriver National Institute of Child Health and Human
   Development [T32HD101392]. Nicki L. Aubuchon-Endsley was supported by
   the National Institute on Alcohol Abuse and Alcoholism [T32AA007459] and
   the National Institute on Drug Abuse [K01DA054324]. The funding agencies
   had no further role in study design; in the collection, analysis and
   interpretation of data; in the writing of the report; and in the
   decision to submit the paper for publication. The content is solely the
   authors' responsibility and does not necessarily represent the official
   views of the National Institutes of Health.
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NR 108
TC 0
Z9 0
U1 0
U2 9
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0012-1630
EI 1098-2302
J9 DEV PSYCHOBIOL
JI Dev. Psychobiol.
PD JAN
PY 2023
VL 65
IS 1
AR e22354
DI 10.1002/dev.22354
PG 14
WC Developmental Biology; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Developmental Biology; Psychology
GA 6W5JJ
UT WOS:000895764700001
PM 36567656
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Holt, RIG
   Pendlebury, J
   Wildgust, HJ
   Bushe, CJ
AF Holt, Richard I. G.
   Pendlebury, John
   Wildgust, Hiram J.
   Bushe, Chris J.
TI Intentional Weight Loss in Overweight and Obese Patients With Severe
   Mental Illness: 8-Year Experience of a Behavioral Treatment Program
SO JOURNAL OF CLINICAL PSYCHIATRY
LA English
DT Article
ID CORONARY-HEART-DISEASE; RANDOMIZED CLINICAL-TRIAL; WELL-BEING PROGRAM;
   ANTIPSYCHOTIC-DRUGS; METABOLIC SYNDROME; SERVICE EVALUATION; HEALTH;
   RISK; GAIN; MANAGEMENT
AB Objective: Obesity is 2 to 3 times more common among people with severe mental illness and has adverse effects on physical and psychological health. We report the experience from the first 8 years of a self-referring weight management clinic.
   Method: From 2000 to 2008, 113 patients with severe mental illness (according to ICD-10 criteria) with a mean SE age of 43.8 +/- 1.7 years (range, 22-71 years) referred themselves to this clinic. The patients were seen in weekly group sessions lasting 1 hour that involved weight measurement, discussion, and education. The response to the program was assessed by the paired Student t test and linear analysis corrected for repeated measures.
   Results: Mean SE baseline weight was 90.1 +/- 1.6 kg (body mass index [BMI] =32.2 0.5 kg/m(2)). Fifty subjects of the 142 total patient episodes (35%) dropped out within the first 3 months. Sixty-four subjects completed 1 year of the program, and 35 have attended for 2 years or longer. There were progressive statistically significant reductions in mean weight and BMI throughout the duration of monitoring, with no suggestion of a plateau. The mean SE final weight loss was 7.2 0.6 kg. Weight loss was correlated only with the number of sessions attended (r=0.42, P <.0001).
   Conclusions: Lifestyle advice within a group setting may be effective in long-term management of obese and overweight patients with severe mental illness. Clin Psychiatry 2010;71(6):800-805 Copyright (C) 2010 Physicians Postgraduate Press, Inc.
C1 [Holt, Richard I. G.] Univ Southampton, Sch Med, Dev Origins Hlth & Dis Div, Manchester, Lancs, England.
   [Pendlebury, John] Greater Manchester W Mental Hlth Natl Hlth Serv F, Manchester, Lancs, England.
   [Wildgust, Hiram J.] Hiram Consulting Ltd, Ackworth, Pontefract, W Yorkshire, England.
   [Bushe, Chris J.] Eli Lilly, Basingstoke, Hants, England.
C3 University of Manchester; University of Southampton; Eli Lilly
RP Pendlebury, J (corresponding author), Cromwell House,Cromwell Rd, Manchester M30 0GT, Lancs, England.
EM john@pendlebury.freeserve.co.uk
OI Holt, Richard/0000-0001-8911-6744
FU National Health Service; University of Southampton, United Kingdom
FX This service evaluation is funded by the National Health Service and the
   University of Southampton, United Kingdom.
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NR 32
TC 27
Z9 29
U1 0
U2 11
PU PHYSICIANS POSTGRADUATE PRESS
PI MEMPHIS
PA P O BOX 752870, MEMPHIS, TN 38175-2870 USA
SN 0160-6689
EI 1555-2101
J9 J CLIN PSYCHIAT
JI J. Clin. Psychiatry
PD JUN
PY 2010
VL 71
IS 6
BP 800
EP 805
DI 10.4088/JCP.09m05627gre
PG 6
WC Psychology, Clinical; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA 612DN
UT WOS:000278877100017
PM 20361917
DA 2025-06-11
ER

PT J
AU Yu, HT
   Fu, XY
   Liang, B
   Wang, S
   Liu, JK
   Wang, SR
   Feng, ZH
AF Yu, Hai-Tao
   Fu, Xiao-Yi
   Liang, Bing
   Wang, Shuang
   Liu, Jian-Kang
   Wang, Shu-Ran
   Feng, Zhi-Hui
TI Oxidative damage of mitochondrial respiratory chain in different organs
   of a rat model of diet-induced obesity
SO EUROPEAN JOURNAL OF NUTRITION
LA English
DT Article
DE Mitochondria; Respiratory chain; Complex; Oxidative stress; Obesity
ID FATTY LIVER-DISEASE; METABOLIC SYNDROME; SKELETAL-MUSCLE; DYSFUNCTION;
   STRESS; CANCER; DNA; PHOSPHORYLATION; STEATOHEPATITIS; HEART
AB Mitochondrial dysfunction plays an important role in the development of obesity and obesity-associated metabolic diseases.
   In this study, we dynamically observed the characteristics of mitochondrial damage in a rat model of diet-induced obesity (DIO). From the 2nd to the 10th week, animals were killed every 2 weeks and the heart, liver, kidney, and testicular tissues were harvested. Mitochondria were isolated and the activities of respiratory chain complexes I, II, III, and IV as well as the 8-Hydroxy-2-deoxy Guanosine content were determined. Reactive oxygen species and malondialdehyde were measured.
   Mitochondrial damages were observed in the heart and liver of DIO and DR rats, and the damages occurred later in DR group than that in DIO group. The mitochondrial membrane potential of heart and liver decreased in DIO and DR groups. The activity of the heart mitochondria complexes I, III, and IV (composing NADH oxidative respiratory) was higher in the early stage of DIO and lower in the end of week 10. The higher activity of the liver complexes I, III, and IV was found until the end of week 10 in DIO and DR groups, accompanied with enhanced oxidative stress. Besides, mitochondrial DNA damages were observed in all tissues.
   In DIO rats, the heart mitochondrial dysfunction occurred first and the liver presented the strongest compensatory ability against oxidative stress.
C1 [Yu, Hai-Tao; Fu, Xiao-Yi; Wang, Shu-Ran] Jilin Med Univ, Sch Publ Hlth, 5 Jilin St, Jilin 132013, Jilin, Peoples R China.
   [Liu, Jian-Kang; Feng, Zhi-Hui] Xi An Jiao Tong Univ, Ctr Mitochondrial Biol & Med, Key Lab Biomed Informat Engn, Minist Educ,Sch Life Sci & Technol, 28 W Xian Ning Rd, Xian 710049, Shanxi, Peoples R China.
   [Liu, Jian-Kang; Feng, Zhi-Hui] Xi An Jiao Tong Univ, Frontier Inst Sci & Technol, 28 W Xian Ning Rd, Xian 710049, Shanxi, Peoples R China.
   [Liang, Bing] Peoples Liberat Army Gen Hosp, HaiNan Branch, Sanya 572014, Hainan, Peoples R China.
   [Wang, Shuang] Ctr Dis Control & Prevent, Beijing 101100, Peoples R China.
C3 Jilin Medical University; Xi'an Jiaotong University; Ministry of
   Education - China; Xi'an Jiaotong University; Chinese People's
   Liberation Army General Hospital; Chinese Center for Disease Control &
   Prevention
RP Wang, SR (corresponding author), Jilin Med Univ, Sch Publ Hlth, 5 Jilin St, Jilin 132013, Jilin, Peoples R China.; Feng, ZH (corresponding author), Xi An Jiao Tong Univ, Ctr Mitochondrial Biol & Med, Key Lab Biomed Informat Engn, Minist Educ,Sch Life Sci & Technol, 28 W Xian Ning Rd, Xian 710049, Shanxi, Peoples R China.; Feng, ZH (corresponding author), Xi An Jiao Tong Univ, Frontier Inst Sci & Technol, 28 W Xian Ning Rd, Xian 710049, Shanxi, Peoples R China.
EM shuranwang2014@163.com; zhfeng@mail.xjtu.edu.cn
RI wang, shuran/KFF-5332-2024; Liu, Jiankang/A-1610-2011; Feng,
   Zhihui/E-7408-2011
OI Feng, Zhihui/0000-0002-2448-6565
FU National Natural Science Foundation of China [81072297, 81472964]
FX This work was supported by research Grants from the National Natural
   Science Foundation of China (81072297 and 81472964). Chang Bai Shan
   Scholars Program of Jilin Province, China.
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NR 29
TC 18
Z9 19
U1 1
U2 31
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1436-6207
EI 1436-6215
J9 EUR J NUTR
JI Eur. J. Nutr.
PD AUG
PY 2018
VL 57
IS 5
BP 1957
EP 1967
DI 10.1007/s00394-017-1477-0
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA GN3SL
UT WOS:000438928300021
PM 28573457
DA 2025-06-11
ER

PT J
AU Brosnan, MJ
   Carkner, RD
AF Brosnan, M. Julia
   Carkner, Richard D.
TI Hepatic effects of a fructose diet in the stroke-prone spontaneously
   hypertensive rat
SO AMERICAN JOURNAL OF HYPERTENSION
LA English
DT Article
ID STEAROYL-COA DESATURASE-1; HIGH-SUCROSE DIET; INSULIN-RESISTANCE;
   BLOOD-PRESSURE; SUPEROXIDE-DISMUTASE; GENE-EXPRESSION; ENDOTHELIAL
   DYSFUNCTION; METABOLIC SYNDROME; OXIDATIVE STRESS; CONSUMPTION
AB BACKGROUND Feeding stroke-prone spontaneously hypertensive rats (SHRSP) a diet rich in fructose results in a profound glucose intolerance not observed in the normotensive Wistar Kyoto (WKY) strain. The aim of this study was to investigate the role of the liver in the underlying mechanisms in the SHRSP.
   METHODS SHRSP and WKY rats were fed either 60% fructose or regular chow for 2 weeks with blood pressure being measured using tail-cuff plethysmography and radiotelemetry. Intraperitoneal glucose tolerance tests were performed and livers harvested for analysis of expression of inflammatory mediators and antioxidant proteins by western blotting and quantitative reverse transcriptase-PCR. The serum triglyceride content and fatty acid profiles were also measured.
   RESULTS Feeding SHRSP and WKY on 60% fructose for 2 weeks resulted in glucose intolerance with no increases in levels of blood pressure. Serum triglycerides were increased in both strains of fructose-fed rats with the highest levels being observed in the SHRSP. The serum fatty acid profiles were changed with large increases in the amounts of oleic acid (18.1) and reductions in linoleic acid (18.2). Levels of expression of c-jun N-terminal kinase/stress activated protein kinase (JNK/SAPK), and nuclear factor kappa B (NF-kappa B) were shown to be unchanged between the livers of the chow and fructose-fed groups. In contrast, protein levels of the three isoforms of superoxide dismutase (SOD) were upregulated in liver of SHRSP fed on fructose while only manganese SOD (MnSOD) was upregulated in fructose-fed WKY rats.
   CONCLUSIONS These results demonstrate that the major contribution of the liver in the early pathogenesis of metabolic syndrome may be an increased secretion of triglyceride containing altered proportions of fatty acid pools. Feeding rats a diet rich in fructose does not affect hepatic expression of inflammatory pathways and the increased hepatic SOD expression may constitute an early protective mechanism.
C1 [Brosnan, M. Julia; Carkner, Richard D.] Ordway Res Inst, Ctr Metab Dis, Albany, NY USA.
   [Brosnan, M. Julia] Albany Med Coll, Ctr Cardiovasc Sci, Albany, NY 12208 USA.
C3 Ordway Research Institute; Albany Medical College
RP Brosnan, MJ (corresponding author), Ordway Res Inst, Ctr Metab Dis, Albany, NY USA.
EM jbrosnan@ordwayresearch.org
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NR 37
TC 5
Z9 5
U1 0
U2 0
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 0895-7061
J9 AM J HYPERTENS
JI Am. J. Hypertens.
PD JUN
PY 2008
VL 21
IS 6
BP 708
EP 714
DI 10.1038/ajh.2008.41
PG 7
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 300RB
UT WOS:000255841800023
PM 18437120
OA Bronze
DA 2025-06-11
ER

PT J
AU Chattopadhyay, M
   Khemka, VK
   Chatterjee, G
   Ganguly, A
   Mukhopadhyay, S
   Chakrabarti, S
AF Chattopadhyay, Mrittika
   Khemka, Vineet Kumar
   Chatterjee, Gargi
   Ganguly, Anirban
   Mukhopadhyay, Satinath
   Chakrabarti, Sasanka
TI Enhanced ROS production and oxidative damage in subcutaneous white
   adipose tissue mitochondria in obese and type 2 diabetes subjects
SO MOLECULAR AND CELLULAR BIOCHEMISTRY
LA English
DT Article
DE Diabetes; Obesity; Oxidative stress; Adipose tissue; Mitochondrial
   dysfunction
ID OXYGEN SPECIES PRODUCTION; NF-KAPPA-B; SKELETAL-MUSCLE; ANTIOXIDANT
   SUPPLEMENTATION; INSULIN-RESISTANCE; METABOLIC SYNDROME; STRESS;
   DYSFUNCTION; DISEASE; RESPIRATION
AB Oxidative stress in the insulin target tissues has been implicated in the pathophysiology of type 2 diabetes. The study has examined the oxidative stress parameters in the mitochondria of subcutaneous white adipose tissue from obese and non-obese subjects with or without type 2 diabetes. An accumulation of protein carbonyls, fluorescent lipid peroxidation products, and malondialdehyde occurs in the adipose tissue mitochondria of obese type 2 diabetic, non-diabetic obese, and non-obese diabetic subjects with the maximum increase noticed in the obese type 2 diabetes patients and the minimum in non-obese type 2 diabetics. The mitochondria from obese type 2 diabetics, non-diabetic obese, and non-obese type 2 diabetics also produce significantly more reactive oxygen species (ROS) in vitro compared to those of controls, and apparently the mitochondrial ROS production rate in each group is proportional to the respective load of oxidative damage markers. Likewise, the mitochondrial antioxidant enzymes like superoxide dismutase and glutathione peroxidase show decreased activities most markedly in obese type 2 diabetes subjects and to a lesser degree in non-obese type 2 diabetes or non-diabetic obese subjects in comparison to control. The results imply that mitochondrial dysfunction with enhanced ROS production may contribute to the metabolic abnormality of adipose tissue in obesity and diabetes.
C1 [Chattopadhyay, Mrittika; Khemka, Vineet Kumar; Chatterjee, Gargi; Ganguly, Anirban; Chakrabarti, Sasanka] Inst Post Grad Med Educ & Res, Dept Biochem, Kolkata 700020, India.
   [Mukhopadhyay, Satinath] Inst Post Grad Med Educ & Res, Dept Endocrinol & Metab, Kolkata 700020, India.
C3 Institute of Post Graduate Medical Education & Research (IPGMER),
   Kolkata; Institute of Post Graduate Medical Education & Research
   (IPGMER), Kolkata
RP Chakrabarti, S (corresponding author), Inst Post Grad Med Educ & Res, Dept Biochem, 244 Acharya JC Bose Rd, Kolkata 700020, India.
EM profschakrabarti95@gmail.com
RI Chakrabarti, Sasanka/AFG-0537-2022; Ganguly, Dr Anirban/AGX-8295-2022;
   Ganguly, Dr Anirban/KMY-6297-2024
OI Mukhopadhyay, Satinath/0000-0001-8033-5748; CHAKRABARTI,
   SASANKA/0000-0002-9429-4892; Ganguly, Dr Anirban/0000-0002-5007-7116;
   Khemka, Vineet/0000-0003-4375-5780
FU Council of Scientific and Industrial Research (CSIR), Government of
   India [27(0202)/09/EMR-II]
FX The study was supported by a Grant from Council of Scientific and
   Industrial Research (CSIR), Government of India. (No.
   27(0202)/09/EMR-II, 2009-2012). We are thankful to Dr. Manoj Khanna,
   Cosmetic Surgeon for his generous help in providing the adipose tissue
   obtained by liposuction and Ms. Indrani Roy for technical help in tissue
   processing. We thank the West Bengal University of Health Sciences for
   their help and encouragement.
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NR 47
TC 118
Z9 128
U1 0
U2 27
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0300-8177
EI 1573-4919
J9 MOL CELL BIOCHEM
JI Mol. Cell. Biochem.
PD JAN
PY 2015
VL 399
IS 1-2
BP 95
EP 103
DI 10.1007/s11010-014-2236-7
PG 9
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA AW4HN
UT WOS:000346241900011
PM 25312902
DA 2025-06-11
ER

PT J
AU Carlström, M
   Larsson, SC
AF Carlstrom, Mattias
   Larsson, Susanna C.
TI Coffee consumption and reduced risk of developing type 2 diabetes: a
   systematic review with meta-analysis
SO NUTRITION REVIEWS
LA English
DT Review
DE cardiovascular; coffee; diabetes; inflammation; metabolic syndrome;
   oxidative stress; renal; type 2
ID DOSE-RESPONSE METAANALYSIS; GLOMERULAR-FILTRATION-RATE; IMPAIRED FASTING
   GLUCOSE; LIFE-STYLE INTERVENTION; DNA STRAND BREAKS; DARK ROAST COFFEE;
   OXIDATIVE STRESS; METABOLIC SYNDROME; TEA CONSUMPTION; ANTIOXIDANT
   CAPACITY
AB Context: Type 2 diabetes (T2D) is a major health problem worldwide that is associated with increased morbidity and mortality. There is increased interest in the value of different nutrition-based strategies for preventing the development of T2D. Objective: This review aims to cover current knowledge regarding the effects of coffee consumption on development of T2D or modulation of adverse complications. A meta-analysis on coffee consumption and the risk of T2D was conducted. Moreover, bioactive components in coffee, polymorphisms, and potential underlying mechanism(s) in relation to T2D and adverse complications are discussed. Data sources: PubMed was searched up to December 1, 2017, and prospective cohort and nested case-control studies of the association between coffee consumption and T2D risk were selected. Data extraction: Two investigators independently extracted data from included studies. Results: A total of 30 prospective studies with 1 185 210 participants and 53 018 incident T2D cases were included in the meta-analysis. The pooled relative risk (RR) was 0.71 (95% confidence interval [CI], 0.67-0.76) for the highest category of coffee consumption (median consumption, 5 cups/d) vs the lowest category (median consumption, 0 cups/d). The risk of T2D decreased by 6% (RR = 0.94; 95% CI, 0.93-0.95) for each cup-per-day increase in coffee consumption. Results were similar for caffeinated coffee consumption (per additional cup of coffee per day: RR = 0.93; 95% CI, 0.90-0.96) and decaffeinated coffee consumption (corresponding RR = 0.94; 95% CI, 0.90-0.98). Conclusions: Available evidence indicates that coffee consumption is inversely associated with risk of T2D. Possible mechanisms behind this association include thermogenic, antioxidative, and anti-inflammatory effects; modulation of adenosine receptor signaling; and microbiome content and diversity.
C1 [Carlstrom, Mattias] Karolinska Inst, Dept Physiol & Pharmacol, Nanna Svartz Vag 2, SE-17177 Stockholm, Sweden.
   [Larsson, Susanna C.] Karolinska Inst, Inst Environm Med, Unit Nutr Epidemiol, Stockholm, Sweden.
C3 Karolinska Institutet; Karolinska Institutet
RP Carlström, M (corresponding author), Karolinska Inst, Dept Physiol & Pharmacol, Nanna Svartz Vag 2, SE-17177 Stockholm, Sweden.
EM mattias.carlstrom@ki.se
RI Larsson, Susanna/F-6065-2015; Carlstrom, Mattias/E-7350-2015
OI Carlstrom, Mattias/0000-0001-9923-8729; Larsson,
   Susanna/0000-0003-0118-0341
FU Swedish Research Council [2016-01381, 521-2011-2639]; Swedish Heart and
   Lung Foundation [20140448, 20170124]; Karolinska Institutet
   [2-560/2015]; Institute for Scientific Information on Coffee (ISIC)
FX This work was supported by grants from the Swedish Research Council
   (2016-01381 and 521-2011-2639), the Swedish Heart and Lung Foundation
   (20140448 and 20170124), Karolinska Institutet Research Funding
   (2-560/2015), and the Institute for Scientific Information on Coffee
   (ISIC).
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NR 179
TC 158
Z9 164
U1 4
U2 75
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0029-6643
EI 1753-4887
J9 NUTR REV
JI Nutr. Rev.
PD JUN
PY 2018
VL 76
IS 6
BP 395
EP 417
DI 10.1093/nutrit/nuy014
PG 23
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA GF3JE
UT WOS:000431850100001
PM 29590460
OA Bronze
DA 2025-06-11
ER

PT J
AU Ali, M
   Ahmed, M
   Memon, M
   Chandio, F
   Shaikh, Q
   Parveen, A
   Phull, AR
AF Ali, Majida
   Ahmed, Madiha
   Memon, Mehwish
   Chandio, Fozia
   Shaikh, Quratulain
   Parveen, Amna
   Phull, Abdul-Rehman
TI Preeclampsia: A comprehensive review
SO CLINICA CHIMICA ACTA
LA English
DT Review
DE Preeclampsia; Nanomedicines; Biomarkers; Etiology; Inflammation;
   Oxidative stress
ID GESTATIONAL DIABETES-MELLITUS; OXIDATIVE STRESS; GUT MICROBIOTA;
   HYPERTENSIVE DISORDERS; PERIODONTAL-DISEASE; PREGNANCY OUTCOMES;
   INSULIN-RESISTANCE; RISK-FACTORS; WEIGHT-GAIN; WOMEN
AB Preeclampsia (PE) is a life-threatening disease of pregnancy and a prominent cause of neonatal and maternal mortality and morbidity. PE affects approximately 5-10% of pregnancies worldwide, posing significant risks to perinatal and maternal health. It is characterized by a variety of interconnected pathological cascades contributing to the stimulation of intravascular inflammation, oxidative stress (OS), endothelial cell activation, and syncytiotrophoblast stress that converge on a common pathway, ultimately resulting in disease progression. The present study was designed and executed to review the existing scientific literature, specifically focusing on the etiology (gestational diabetes mellitus and maternal obesity, insulin resistance, metabolic syndrome, maternal infection, periodontal disease, altered microbiome, and genetics), clinical presentations (hypertension, blood disorders, proteinuria, hepatic dysfunction, renal dysfunction, pulmonary edema, cardiac dysfunction, fetal growth restrictions, and eclampsia), therapeutic clinical biomarkers (creatinine, albuminuria, and cystatin C) along with their associations and mechanisms in PE. In addition, this study provides insights into the potential of nanomedicines for targeting these mechanisms for PE management and treatment. Inflammation, OS, proteinuria, and an altered microbiome are prominent biomarkers associated with progression and PE-related pathogenesis. Understanding the molecular mechanisms, exploring suitable markers, targeted interventions, comprehensive screening, and holistic strategies are critical to decreasing the incidence of PE and promoting maternal-fetal well-being. The present study comprehensively reviewed the etiology, clinical presentations, therapeutic biomarkers, and preventive potential of nanomedicines in the treatment and management of PE.
C1 [Ali, Majida; Chandio, Fozia; Shaikh, Quratulain] Shaheed Mohtarma Benazir Bhutto Med Univ SMBB Lark, Shaikh Zaid Women Hosp Larkana, Dept Gynecol & Obstet, Larkana, Pakistan.
   [Ahmed, Madiha] Shifa Tameer E Millat Univ, Shifa Coll Pharmaceut Sci, Jaffer Khan Jamali Rd H-8-4, Islamabad, Pakistan.
   [Memon, Mehwish] Ibn e Sina Univ, Dept Biochem, Mirpur Khas, Pakistan.
   [Parveen, Amna] Gachon Univ, Coll Pharm, 191 Hambakmoero, Incheon 21936, South Korea.
   [Phull, Abdul-Rehman] Shah Abdul Latif Univ, Dept Biochem, Khairpur, Sindh, Pakistan.
C3 Gachon University; Shah Abdul Latif University
RP Parveen, A (corresponding author), Gachon Univ, Coll Pharm, 191 Hambakmoero, Incheon 21936, South Korea.; Phull, AR (corresponding author), Shah Abdul Latif Univ, Dept Biochem, Khairpur, Sindh, Pakistan.
EM amnaparvin@gachon.ac.kr; ab.rehman111@yahoo.com
RI Shaikh, Quratulain/H-4832-2019; Phull, Abdul Rehman/Q-4836-2016
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NR 241
TC 3
Z9 3
U1 12
U2 16
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0009-8981
EI 1873-3492
J9 CLIN CHIM ACTA
JI Clin. Chim. Acta
PD SEP 15
PY 2024
VL 563
AR 119922
DI 10.1016/j.cca.2024.119922
EA AUG 2024
PG 23
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA D7D2M
UT WOS:001297743500001
PM 39142550
DA 2025-06-11
ER

PT J
AU Ross, D
   Siegel, D
AF Ross, David
   Siegel, David
TI The diverse functionality of NQO1 and its roles in redox control
SO REDOX BIOLOGY
LA English
DT Review
DE NQO1; DT-Diaphorase; Quinone; Redox switch; Nrf2; Oxidative stress
ID NAD(P)H QUINONE OXIDOREDUCTASE; DIET-INDUCED OBESITY; UBIQUINONE
   REDUCTASE-ACTIVITY; DT-DIAPHORASE ACTIVITY; TUMOR-SELECTIVE USE; INDUCED
   DNA-DAMAGE; LOSS-OF-FUNCTION; HIGH-FAT DIET; NAD(P)H-QUINONE
   OXIDOREDUCTASE; OXIDATIVE STRESS
AB In this review, we summarize the multiple functions of NQO1, its established roles in redox processes and potential roles in redox control that are currently emerging. NQO1 has attracted interest due to its roles in cell defense and marked inducibility during cellular stress. Exogenous substrates for NQO1 include many xenobiotic quinones. Since NQO1 is highly expressed in many solid tumors, including via upregulation of Nrf2, the design of compounds activated by NQO1 and NQO1-targeted drug delivery have been active areas of research. Endogenous substrates have also been proposed and of relevance to redox stress are ubiquinone and vitamin E quinone, components of the plasma membrane redox system. Established roles for NQO1 include a superoxide reductase activity, NAD+ generation, interaction with proteins and their stabilization against proteasomal degradation, binding and regulation of mRNA translation and binding to microtubules including the mitotic spindles. We also summarize potential roles for NQO1 in regulation of glucose and insulin metabolism with relevance to diabetes and the metabolic syndrome, in Alzheimer?s disease and in aging. The conformation and molecular interactions of NQO1 can be modulated by changes in the pyridine nucleotide redox balance suggesting that NQO1 may function as a redox-dependent molecular switch.
C1 [Ross, David; Siegel, David] Univ Colorado, Skaggs Sch Pharm & Pharmaceut Sci, Dept Pharmaceut Sci, Anschutz Med Campus, Aurora, CO 80045 USA.
C3 University of Colorado System; University of Colorado Anschutz Medical
   Campus
RP Ross, D (corresponding author), Univ Colorado, Skaggs Sch Pharm & Pharmaceut Sci, Anschutz Med Campus, Aurora, CO 80045 USA.
EM david.ross@cuanschutz.edu
OI Siegel, David/0000-0001-5314-1622
FU NIH [R01DK109964]; National Institute of Diabetes and Digestive and
   Kidney Diseases [R01DK109964] Funding Source: NIH RePORTER
FX DR and DS were supported in part by NIH grant R01DK109964.
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NR 270
TC 291
Z9 309
U1 12
U2 133
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2213-2317
J9 REDOX BIOL
JI Redox Biol.
PD MAY
PY 2021
VL 41
AR 101950
DI 10.1016/j.redox.2021.101950
EA MAR 2021
PG 14
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA RX8ZW
UT WOS:000647507800001
PM 33774477
OA gold, Green Published
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Godisela, KK
   Reddy, SS
   Kumar, CU
   Saravanan, N
   Reddy, PY
   Jablonski, MM
   Ayyagari, R
   Reddy, GB
AF Godisela, Kishore Kumar
   Reddy, Singareddy Sreenivasa
   Kumar, Chekkilla Uday
   Saravanan, Natarajan
   Reddy, Paduru Yadagiri
   Jablonski, Monica M.
   Ayyagari, Radha
   Reddy, Geereddy Bhanuprakash
TI Impact of obesity with impaired glucose tolerance on retinal
   degeneration in a rat model of metabolic syndrome
SO MOLECULAR VISION
LA English
DT Article
ID ATHEROSCLEROSIS RISK; MACULAR DEGENERATION; ABDOMINAL OBESITY;
   EXPRESSION; CATARACT; DISEASE
AB Purpose: Metabolic syndrome (MetS) is associated with several degenerative diseases, including retinal degeneration. Previously, we reported on progressive retinal degeneration in a spontaneous obese rat (WNIN/Ob) model. In this study, we investigated the additional effect of impaired glucose tolerance (IGT), an essential component of MetS, on retinal degeneration using the WNIN/GR-Ob rat model.
   Methods: The retinal morphology and ultrastructure of WNIN/GR-Ob and age-matched littermate lean rats were studied by microscopy and immunohistochemistry. The retinal transcriptome of WNIN/GR-Ob was compared with the respective lean controls and with the WNIN/Ob model using microarray analysis. Expression of selected retinal marker genes was studied via real-time PCR.
   Results: Progressive loss of photoreceptor cells was observed in WNIN/GR-Ob rats with an onset as early as 3 months. Similarly, thinning of the inner nuclear layer was observed from 6 months in these rats. Immunohistochemical analysis showed decreased levels of rhodopsin and postsynaptic density protein-95 (PSD-95) proteins and increased levels of glial fibrillary acidic protein (GFAP), vascular endothelial growth factor (VEGF), and calretinin in WNIN/GR-Ob rats compared with the age-matched lean controls, further supporting cellular stress/damage and retinal degeneration. The retinal transcriptome analysis indicated altered expression profiles in both the WNIN/GR-Ob and WNIN/Ob rat models compared to their respective lean controls; these pathways are associated with activation of pathways like cellular oxidative stress response, inflammation, apoptosis, and phototransduction, although the changes were more prominent in WNIN/GR-Ob than in WNIN/Ob animals.
   Conclusions: WNIN/GR-Ob rats with added glucose intolerance developed retinal degeneration similar to the parent line WNIN/Ob. The severity of retinal degeneration was greater in WNIN/GR-Ob rats compared to WNIN/Ob, suggesting a possible role for IGT in this model. Hence, the WNIN/GR-Ob model could be a valuable tool for investigating the impact of MetS on retinal degeneration pathology.
C1 [Godisela, Kishore Kumar; Reddy, Singareddy Sreenivasa; Kumar, Chekkilla Uday; Saravanan, Natarajan; Reddy, Paduru Yadagiri; Reddy, Geereddy Bhanuprakash] Natl Inst Nutr, Hyderabad, Andhra Pradesh, India.
   [Jablonski, Monica M.] Univ Tennessee, Memphis, TN USA.
   [Ayyagari, Radha] Univ Calif San Diego, Shiley Eye Inst, La Jolla, CA 92093 USA.
C3 Indian Council of Medical Research (ICMR); ICMR - National Institute of
   Nutrition (NIN); University of Tennessee System; University of Tennessee
   Health Science Center; University of California System; University of
   California San Diego
RP Reddy, GB (corresponding author), Jamai Osmania, Natl Inst Nutr, Hyderabad 500604, Andhra Pradesh, India.
EM geereddy@yahoo.com
RI CHEKKILLA, UDAY KUMAR/IQV-1932-2023; Reddy, G.
   Bhanuprakash/AAJ-3494-2020
OI Reddy, Sreenivasa/0000-0003-3777-407X; Chekkilla, Uday
   Kumar/0000-0003-0255-5707; Reddy, G. Bhanuprakash/0000-0003-4787-3944
FU SERB (Science and Engineering research board) [SB/YS/LS-271/2013];
   Department of Biotechnology, Government of India under the Indo-US
   Vision Research Program [BT/PR11097/Med/12/411/2008]; Foundation
   Fighting Blindness, Research to Prevent Blindenss [NIH-EY21237,
   P30-EY22589]; Research to Prevent Blindness;  [NIH-EY021200]
FX KKG is a Fellow of University Grants Commission-Faculty Development
   Program. SSR received a grant from SERB (Science and Engineering
   research board) SB/YS/LS-271/2013. GBR received grants from Department
   of Biotechnology, Government of India (BT/PR11097/Med/12/411/2008) under
   the Indo-US Vision Research Program. RA was supported by The Foundation
   Fighting Blindness, Research to Prevent Blindenss, NIH-EY21237,
   P30-EY22589 grants. MMJ was supported by an unrestricted grant from
   Research to Prevent Blindness and NIH-EY021200. The authors are grateful
   to Dr. Satish K. Madala, Pulmonary Medicine, Cincinnati Children's
   Hospital Medical Center, Cincinnati (USA) for the help with
   transcriptome analysis for functional pathways or diseases using
   Ingenuity Pathway Analysis program. The authors acknowledge Dr. N. V.
   Giridharan, National Institute of Nutrition, Hyderabad, for critical
   inputs into the study.
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NR 39
TC 13
Z9 13
U1 0
U2 0
PU MOLECULAR VISION
PI ATLANTA
PA C/O JEFF BOATRIGHT, LAB B, 5500 EMORY EYE CENTER, 1327 CLIFTON RD, N E,
   ATLANTA, GA 30322 USA
SN 1090-0535
J9 MOL VIS
JI Mol. Vis.
PD APR 14
PY 2017
VL 23
BP 263
EP 274
PG 12
WC Biochemistry & Molecular Biology; Ophthalmology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Ophthalmology
GA ES1LH
UT WOS:000399288600004
PM 28465658
DA 2025-06-11
ER

PT J
AU Ideta, T
   Shirakami, Y
   Ohnishi, M
   Maruta, A
   Obara, K
   Miyazaki, T
   Kochi, T
   Sakai, H
   Tomita, H
   Tanaka, T
   Blaner, WS
   Shimizu, M
AF Ideta, Takayasu
   Shirakami, Yohei
   Ohnishi, Masaya
   Maruta, Akinori
   Obara, Koki
   Miyazaki, Tsuneyuki
   Kochi, Takahiro
   Sakai, Hiroyasu
   Tomita, Hiroyuki
   Tanaka, Takuji
   Blaner, William S.
   Shimizu, Masahito
TI Non-alcoholic steatohepatitis-related liver tumorigenesis is suppressed
   in mice lacking hepatic retinoid storage
SO ONCOTARGET
LA English
DT Article
DE retinoid; hepatocellular carcinoma (HCC); non-alcoholic steatohepatitis
   (NASH); lecithin: retinol acyltransferase (LRAT); oxidative stress
ID DIABETIC C57BL/KSJ-DB/DB MICE; HEPATOCELLULAR-CARCINOMA; VITAMIN-A;
   PRENEOPLASTIC LESIONS; METABOLIC SYNDROME; OXIDATIVE STRESS; STEM-CELLS;
   CANCER; ACYLTRANSFERASE; DISEASE
AB Non-alcoholic fatty liver disease has become one of the most common causes of chronic liver disease that can develop into a more serious form, non-alcoholic steatohepatitis, leading to liver cirrhosis and hepatocellular carcinoma. Although hepatic retinoid stores are progressively lost during the development of liver disease, how this affects steatohepatitis and its related hepatocarcinogenesis is unknown. In order to investigate these, we used subcutaneous injection of streptozotocin (0.2 mg/body) and high-fat diet to induce steatohepatitis and hepatic tumorigenesis in lecithin: retinol acyltransferase -deficient mice (n = 10), which lack stored retinoid in the liver, and control mice (n = 12). At the termination of the experiment (16 weeks of age), the development of hepatic tumors was significantly suppressed in mutant mice compared to controls. Lower serum levels of alanine aminotransferase and decreased hepatic levels of cyclin D1 were observed in mutant mice. Mutant mice exhibited increased levels of retinoic acid-responsive genes, including p21, and decreased oxidative stress as evaluated by serum and liver markers. Our findings are consistent with the conclusion that mutant mice are less susceptible to steatohepatitis-related liver tumorigenesis due to increased retinoid signaling, which is accompanied by upregulated p21 expression and attenuated oxidative stress.
C1 [Ideta, Takayasu; Shirakami, Yohei; Ohnishi, Masaya; Maruta, Akinori; Obara, Koki; Miyazaki, Tsuneyuki; Kochi, Takahiro; Sakai, Hiroyasu; Shimizu, Masahito] Gifu Univ, Grad Sch Med, Dept Gastroenterol, Gifu, Japan.
   [Shirakami, Yohei] Gifu Univ, Grad Sch Med, Dept Informat Clin Med, Gifu, Japan.
   [Tomita, Hiroyuki] Gifu Univ, Grad Sch Med, Dept Tumor Pathol, Gifu, Japan.
   [Tanaka, Takuji] Gifu Municipal Hosp, Div Pathol, Gifu, Japan.
   [Blaner, William S.] Columbia Univ, Dept Med, New York, NY USA.
C3 Gifu University; Gifu University; Gifu University; Gifu Municipal
   Hospital; Columbia University
RP Shirakami, Y (corresponding author), Gifu Univ, Grad Sch Med, Dept Gastroenterol, Gifu, Japan.
EM ys2443@gifu-u.ac.jp
RI Tomita, Hiroyuki/L-5571-2019
FU Ministry of Education, Science, Sports and Culture of Japan [25860529,
   26860498, 15K19320, 16K09352, 16K19335, 16K19336]; JSPS; Grants-in-Aid
   for Scientific Research [16K19335, 16K08735, 17K15937, 26860498,
   25860529, 15K19320, 16K19336, 16K09352] Funding Source: KAKEN
FX The work is supported by Grants-in-Aid from the Ministry of Education,
   Science, Sports and Culture of Japan (Grant No. 25860529, 26860498,
   15K19320, 16K09352, 16K19335, and 16K19336) and JSPS Core-to-Core
   Program, A. Advanced Research Networks.
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NR 53
TC 4
Z9 6
U1 0
U2 3
PU IMPACT JOURNALS LLC
PI ORCHARD PARK
PA 6666 E QUAKER ST, STE 1, ORCHARD PARK, NY 14127 USA
EI 1949-2553
J9 ONCOTARGET
JI Oncotarget
PD SEP 19
PY 2017
VL 8
IS 41
BP 70695
EP 70706
DI 10.18632/oncotarget.19978
PG 12
WC Oncology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Cell Biology
GA FH4TA
UT WOS:000411153300118
PM 29050312
OA Green Submitted, gold, Green Published
DA 2025-06-11
ER

PT J
AU Ren, DY
   Hu, YY
   Luo, YY
   Yang, XB
AF Ren, Daoyuan
   Hu, Yuanyuan
   Luo, Yiyang
   Yang, Xingbin
TI Selenium-containing polysaccharides from Ziyang green tea ameliorate
   high-fructose diet induced insulin resistance and hepatic oxidative
   stress in mice
SO FOOD & FUNCTION
LA English
DT Article
ID METABOLIC SYNDROME; ANTIOXIDANT ACTIVITIES; MOLECULAR-MECHANISMS;
   DIABETIC-RATS; RICH EXTRACT; FATTY LIVER; IN-VITRO; HYPERGLYCEMIA;
   DYSFUNCTION; OBESITY
AB The present study was designed to evaluate the effects of selenium-containing tea polysaccharides (Se-GTP) from a new variety of selenium-enriched Ziyang green tea against high fructose (HF)-induced insulin resistance and hepatic oxidative stress in mice. Healthy male Kunming mice were fed 20% high fructose water and administered 200, 400 and 800 mg per kg bw Se-GTP for 8 weeks. Mice fed HF in drinking water displayed significant insulin resistance, hepatic steatosis and oxidative stress observed by hyperglycemia and hyperinsulinemia, as well as increases in hepatic non-esterified fatty acid (NEFA) and malonaldehyde (MDA). The administration of Se-GTP at 400 and 800 mg per kg bw significantly improved insulin sensitivity, and reduced liver steatosis and oxidative stress damage, and brought back the antioxidants and hepatic lipids towards near-normal values. In the oral glucose tolerance test, the administration of Se-GTP at 400 and 800 mg per kg bw had reduced plasma glucose concentrations after 30 min of glucose loading in HF-fed mice, suggesting that Se-GTP improved glucose intolerance. Histopathological examination indicated that the impaired pancreatic/hepatic tissues were effectively restored in HF-fed mice following the Se-GTP treatment. This is the first report showing that Se-GTP can ameliorate the high fructose-induced insulin resistance and hepatic oxidative injury.
C1 [Ren, Daoyuan; Hu, Yuanyuan; Luo, Yiyang; Yang, Xingbin] Shaanxi Normal Univ, Key Lab, Minist Educ Med Resource & Nat Pharmaceut Chem, Coll Food Engn & Nutr Sci, Xian 710062, Peoples R China.
C3 Shaanxi Normal University
RP Ren, DY (corresponding author), Shaanxi Normal Univ, Key Lab, Minist Educ Med Resource & Nat Pharmaceut Chem, Coll Food Engn & Nutr Sci, Xian 710062, Peoples R China.
EM xbyang@snnu.edu.cn
RI hu, yuan/HTL-4197-2023
OI Hu, Yuanyuan/0000-0001-6788-702X
FU National Natural Science Foundation of China [C31171678]; Excellent
   Doctoral Dissertation Funded Projects of Shaanxi Normal University,
   China [X2014YB09]; Fundamental Research Funds for the Central
   Universities of Shaanxi Normal University, China [GK201501006]
FX This study was supported by the grants from the National Natural Science
   Foundation of China (C31171678), and the Excellent Doctoral Dissertation
   Funded Projects of Shaanxi Normal University, China (X2014YB09), and the
   Fundamental Research Funds for the Central Universities of Shaanxi
   Normal University, China (GK201501006).
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NR 35
TC 64
Z9 71
U1 3
U2 106
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PY 2015
VL 6
IS 10
BP 3342
EP 3350
DI 10.1039/c5fo00557d
PG 9
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA CT2TH
UT WOS:000362656400017
PM 26267675
DA 2025-06-11
ER

PT J
AU Cremonini, E
   Fraga, CG
   Oteiza, PI
AF Cremonini, Eleonora
   Fraga, Cesar G.
   Oteiza, Patricia I.
TI (-)-Epicatechin in the control of glucose homeostasis: Involvement of
   redoxregulated mechanisms
SO FREE RADICAL BIOLOGY AND MEDICINE
LA English
DT Review
DE Flavonoid; Flavanol; Polyphenol; Bioactive; Diabetes; Obesity; Metabolic
   syndrome; Oxidative stress; Incretins; Endotoxemia; Microbiota;
   Intestine; Mitochondria
ID ENDOPLASMIC-RETICULUM STRESS; HEPATIC INSULIN-RESISTANCE;
   FACTOR-KAPPA-B; CARDIOVASCULAR RISK-FACTORS; GLUCAGON-LIKE PEPTIDE-1;
   REDUCES BLOOD-PRESSURE; FAMILY NADPH OXIDASES; DIET-INDUCED OBESITY;
   RICH DARK CHOCOLATE; OXIDATIVE STRESS
AB Emerging evidence supports a beneficial action of the flavan-3-ol (-)-epicatechin (EC) on insulin sensitivity and potential impact on the development/progression of type 2 diabetes (T2D). In humans, supplementation with EC-rich foods, extracts, and pure EC improves insulin sensitivity and glucose tolerance in normal weight, overweight, obese and T2D individuals. These effects of EC are also observed in rodent models of diet-induced obesity and T2D. The events involved in the development of insulin resistance and T2D are multiple and interrelated. EC has been shown to inhibit inflammation, oxidative and endoplasmic reticulum stress, to modulate mitochondrial biogenesis and function, and to regulate events in the gastrointestinal tract and the pancreas that impact glucose homeostasis. A downregulation of oxidant production, particularly through direct inhibition or suppression of NADPH oxidase expression, and of redox sensitive signals (NF-kappa B, JNK1/2) that inhibit the insulin pathway, appear to be central to the beneficial actions of EC on insulin sensitivity. Overall, EC seems to have a positive role in the regulation of glucose homeostasis, however definitive answers on its importance for the management of T2D will depend on further clinical and mechanistic studies.
C1 [Cremonini, Eleonora; Fraga, Cesar G.; Oteiza, Patricia I.] Univ Calif Davis, Dept Nutr, One Shields Ave, Davis, CA 95616 USA.
   [Cremonini, Eleonora; Oteiza, Patricia I.] Univ Calif Davis, Dept Environm Toxicol, One Shields Ave, Davis, CA 95616 USA.
   [Fraga, Cesar G.] Univ Buenos Aires, Fac Farm & Bioquim, Fis Quim, Buenos Aires, DF, Argentina.
   [Fraga, Cesar G.] UBA, CONICET, Inst Bioquim & Med Mol IBIMOL, Buenos Aires, DF, Argentina.
C3 University of California System; University of California Davis;
   University of California System; University of California Davis;
   University of Buenos Aires; University of Buenos Aires; Consejo Nacional
   de Investigaciones Cientificas y Tecnicas (CONICET)
RP Oteiza, PI (corresponding author), Univ Calif Davis, Dept Nutr, One Shields Ave, Davis, CA 95616 USA.; Oteiza, PI (corresponding author), Univ Calif Davis, Dept Environm Toxicol, One Shields Ave, Davis, CA 95616 USA.
EM poteiza@ucdavis.edu
RI Fraga, Cesar/Q-8161-2019
OI Fraga, Cesar G./0000-0003-4168-9927
FU NIFA-USDA, USA [CA-D*-xxx-7244-H]; UBACYT, Argentina [20020160100132BA];
   Packer-Wentz endowment, USA
FX This work was supported by grants from NIFA-USDA (CA-D*-xxx-7244-H), USA
   (PIO); and UBACYT 20020160100132BA, Argentina (CGF); and Packer-Wentz
   endowment, USA (CGF). PIO is an honorary member of CONICET, Argentina.
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NR 147
TC 43
Z9 45
U1 0
U2 40
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0891-5849
EI 1873-4596
J9 FREE RADICAL BIO MED
JI Free Radic. Biol. Med.
PD JAN
PY 2019
VL 130
BP 478
EP 488
DI 10.1016/j.freeradbiomed.2018.11.010
PG 11
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA HG9RR
UT WOS:000455347000044
PM 30447350
OA Bronze
DA 2025-06-11
ER

PT J
AU Cagnin, S
   Pontisso, P
   Martini, A
AF Cagnin, Silvia
   Pontisso, Patrizia
   Martini, Andrea
TI SerpinB3: A Multifaceted Player in Health and Disease-Review and Future
   Perspectives
SO CANCERS
LA English
DT Review
DE SerpinB3; oncology; metabolism; fibrosis; biomarker; protection from
   oxidative stress
ID SQUAMOUS-CELL CARCINOMA; HYPOXIA-INDUCIBLE FACTORS; PROTEASE-ACTIVATED
   RECEPTOR-2; LIVER-DISEASE; WNT/BETA-CATENIN; TISSUE FACTOR;
   BETA-CATENIN; STEM-CELLS; ANTIGEN; CANCER
AB Simple Summary This review highlights SerpinB3's multifaceted roles in liver disease, from fibrosis, carcinogenesis and immune modulation to cell death protection. In different types of cancer its overexpression correlates with tumor aggressiveness; however, in acute oxidative stress conditions, SerpinB3 promotes cell survival. Novel therapeutic strategies targeting SerpinB3 through its upstream regulators are under development, while its therapeutic potential in acute medical conditions has also been proposed.Abstract SerpinB3, a member of the serine-protease inhibitor family, has emerged as a crucial player in various physiological and pathological processes. Initially identified as an oncogenic factor in squamous cell carcinomas, SerpinB3's intricate involvement extends from fibrosis progression and cancer to cell protection in acute oxidative stress conditions. This review explores the multifaceted roles of SerpinB3, focusing on its implications in fibrosis, metabolic syndrome, carcinogenesis and immune system impairment. Furthermore, its involvement in tissue protection from oxidative stress and wound healing underscores its potential as diagnostic and therapeutic tool. Recent studies have described the therapeutic potential of targeting SerpinB3 through its upstream regulators, offering novel strategies for cancer treatment development. Overall, this review underscores the importance of further research to fully elucidate the mechanisms of action of SerpinB3 and to exploit its therapeutic potential across various medical conditions.
C1 [Cagnin, Silvia; Pontisso, Patrizia; Martini, Andrea] Univ Padua, Dept Med, I-35123 Padua, Italy.
C3 University of Padua
RP Pontisso, P (corresponding author), Univ Padua, Dept Med, I-35123 Padua, Italy.
EM silvia.cgn@gmail.com; patrizia@unipd.it; andrea.martini@aopd.veneto.it
RI Martini, Andrea/LRC-4609-2024; Martini, Andrea/K-4869-2017; PONTISSO,
   PATRIZIA/K-3574-2018
OI Martini, Andrea/0000-0002-7958-1906; PONTISSO,
   PATRIZIA/0000-0003-2077-9202
FU University of Padova [CPDA110795]
FX This study was supported in part by the University of Padova [Project
   No. CPDA110795] (P.P.).
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NR 133
TC 3
Z9 3
U1 0
U2 1
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6694
J9 CANCERS
JI Cancers
PD JUL
PY 2024
VL 16
IS 14
AR 2579
DI 10.3390/cancers16142579
PG 15
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA ZP6C1
UT WOS:001276528800001
PM 39061218
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Zhang, Z
   Tang, YH
   Fang, W
   Cui, K
   Xu, D
   Liu, GB
   Chi, SY
   Tan, BP
   Mai, KS
   Ai, QH
AF Zhang, Zhou
   Tang, Yuhang
   Fang, Wei
   Cui, Kun
   Xu, Dan
   Liu, Guobin
   Chi, Shuyan
   Tan, Beiping
   Mai, Kangsen
   Ai, Qinghui
TI Octanoate Alleviates Dietary Soybean Oil-Induced Intestinal Physical
   Barrier Damage, Oxidative Stress, Inflammatory Response and Microbial
   Dysbiosis in Large Yellow Croaker (Larimichthys Crocea)
SO FRONTIERS IN IMMUNOLOGY
LA English
DT Article
DE octanoate; intestinal health; dietary soybean oil; oxidative stress;
   inflammatory response; intestinal microbiota; acetic acid
ID CHAIN FATTY-ACIDS; GUT MICROBIOTA; ATHEROSCLEROSIS; EXPRESSION; GENES
AB Octanoate is a type of classical medium-chain fatty acids, which is widely used to treat neurological and metabolic syndrome. However, the specific role of octanoate in repairing intestinal health impairment is currently unknown. Therefore, we investigated whether dietary octanoate repaired the intestinal damage induced by surplus soybean oil in Larimichthys crocea. In this study, dietary octanoate alleviated abnormal morphology of the intestine and enhanced expression of ZO-1 and ZO-2 to improve intestinal physical barrier. Further, dietary octanoate increased antioxidant enzymic activities and decreased the level of ROS to alleviate the intestinal oxidative stress. Dietary octanoate also attenuated the expression of proinflammatory cytokines and the polarity of macrophage to reduce the intestinal inflammatory response. Moreover, the result of intestinal microbial 16S rRNA sequence showed that dietary octanoate repaired the intestinal mucosal microbial dysbiosis, and increased the relative abundance of Lactobacillus. Dietary octanoate supplementation also increased the level of acetic acid in intestinal content and serum through increasing the abundance of acetate-producing strains. Overall, in Larimichthys crocea, dietary octanoate might alleviated oxidative stress, inflammatory response and microbial dysbiosis to repair the intestinal damage induced by surplus soybean oil. This work provides vital insights into the underlying mechanisms and treatment strategies for intestinal damage in vertebrates.
C1 [Zhang, Zhou; Tang, Yuhang; Fang, Wei; Cui, Kun; Xu, Dan; Liu, Guobin; Mai, Kangsen; Ai, Qinghui] Ocean Univ China, Key Lab Aquaculture Nutr & Feed, Minist Agr & Rural Affairs, Qingdao, Peoples R China.
   [Zhang, Zhou; Tang, Yuhang; Fang, Wei; Cui, Kun; Xu, Dan; Liu, Guobin; Mai, Kangsen; Ai, Qinghui] Ocean Univ China, Key Lab Mariculture, Minist Educ, Qingdao, Peoples R China.
   [Chi, Shuyan; Tan, Beiping] Guangdong Ocean Univ, Coll Fisheries, Lab Aquat Nutr & Feed, Zhanjiang, Peoples R China.
   [Mai, Kangsen; Ai, Qinghui] Qingdao Natl Lab Marine Sci & Technol, Lab Marine Fisheries Sci & Food Prod Proc, Qingdao, Peoples R China.
C3 Ocean University of China; Ministry of Agriculture & Rural Affairs;
   Ocean University of China; Ministry of Education - China; Guangdong
   Ocean University; Laoshan Laboratory
RP Ai, QH (corresponding author), Ocean Univ China, Key Lab Aquaculture Nutr & Feed, Minist Agr & Rural Affairs, Qingdao, Peoples R China.; Ai, QH (corresponding author), Ocean Univ China, Key Lab Mariculture, Minist Educ, Qingdao, Peoples R China.; Ai, QH (corresponding author), Qingdao Natl Lab Marine Sci & Technol, Lab Marine Fisheries Sci & Food Prod Proc, Qingdao, Peoples R China.
EM qhai@ouc.edu.cn
RI Tang, Yu-Hang/C-1164-2019
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NR 49
TC 16
Z9 16
U1 13
U2 56
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-3224
J9 FRONT IMMUNOL
JI Front. Immunol.
PD JUN 29
PY 2022
VL 13
AR 892901
DI 10.3389/fimmu.2022.892901
PG 14
WC Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology
GA 3A7MT
UT WOS:000827440700001
PM 35844501
OA gold, Green Published
DA 2025-06-11
ER

PT S
AU Miyata, T
   Izuhara, Y
AF Miyata, Toshio
   Izuhara, Yuko
BE Schleicher, E
   Somoza, V
   Shieberle, P
TI Inhibition of advanced glycation end products - An implicit goal in
   clinical medicine for the treatment of diabetic nephropathy?
SO MAILLARD REACTION: RECENT ADVANCES IN FOOD AND BIOMEDICAL SCIENCES
SE ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
LA English
DT Article; Proceedings Paper
CT 9th International Symposium on the Maillard Reaction
CY SEP, 2007
CL Munich, GERMANY
DE diabetic nephropathy; blood pressure; renin-angiotensin system;
   oxidative stress; advanced glycation; chronic hypoxia
ID RAT MODEL; RECEPTOR BLOCKERS; PROGRESSION; STRESS; MEGSIN; INJURY;
   OVEREXPRESSION; MECHANISMS; INSULIN
AB Several factors have been incriminated in the genesis of diabetic nephropathy. To elucidate their interplay, we have used a hypertensive, obese, diabetic rat model with nephropathy (SHR/NDmcr-cp) that mimics human type 2 diabetes. This model is characterized by hypertension, obesity with the metabolic syndrome, diabetes with insulin resistance, and intrarenal advanced glycation end product (AGE) accumulation. In order to achieve renoprotection, which was evaluated by histology and albuminuria, various therapeutic approaches were used: caloric restriction, antihypertensive agents (angiotensin 11 receptor blocker [ARB] and calcium channel blocker), lipid-(bezafibrate) or glucose-lowering (insulin and pioglitazone) agents, and cobalt chloride (a hypoxia-inducible factor activator). Altogether, renoprotection is not necessarily associated with blood pressure or glycemic control. By contrast, it is almost always associated with decreased AGE formation, with the exception of insulin, which induces hyperinsulinemia, eventually leading to an overproduction of transforming growth factor-beta. AGE formation is reduced directly by in vitro active compounds (e.g., ARBs) or indirectly by in vitro inactive compounds (e.g., pioglitazone and cobalt). In the latter cases, AGE reduction may reflect a decreased oxidative stress as it is concomitant with a marked reduction of oxidative stress markers. It remains to be seen whether the renoprotection offered by these various approaches may be additive.
C1 [Miyata, Toshio] Tokai Univ, Sch Med, Inst Med Sci, Kanagawa 2591193, Japan.
   Tokai Univ, Sch Med, Div Nephrol Hypertens & Metab, Kanagawa 2591193, Japan.
C3 Tokai University; Tokai University
RP Miyata, T (corresponding author), Tokai Univ, Sch Med, Inst Med Sci, Kanagawa 2591193, Japan.
EM t-miyata@is.icc.u-tokai.ac.jp
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NR 21
TC 13
Z9 15
U1 0
U2 6
PU BLACKWELL PUBLISHING
PI OXFORD
PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXEN, ENGLAND
SN 0077-8923
BN 978-1-57331-719-1
J9 ANN NY ACAD SCI
JI Ann.NY Acad.Sci.
PY 2008
VL 1126
BP 141
EP 146
DI 10.1196/annals.1433.019
PG 6
WC Endocrinology & Metabolism; Food Science & Technology; Multidisciplinary
   Sciences; Neurosciences
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Food Science & Technology; Science &
   Technology - Other Topics; Neurosciences & Neurology
GA BHR75
UT WOS:000255833300025
PM 18448808
DA 2025-06-11
ER

PT J
AU Jia, FP
   Diao, P
   Wang, XJ
   Hu, X
   Kimura, T
   Nakamuta, M
   Nakamura, I
   Shirotori, S
   Sato, Y
   Moriya, K
   Koike, K
   Gonzalez, FJ
   Nakayama, J
   Aoyama, T
   Tanaka, N
AF Jia, Fangping
   Diao, Pan
   Wang, Xiaojing
   Hu, Xiao
   Kimura, Takefumi
   Nakamuta, Makoto
   Nakamura, Ibuki
   Shirotori, Saki
   Sato, Yoshiko
   Moriya, Kyoji
   Koike, Kazuhiko
   Gonzalez, Frank J.
   Nakayama, Jun
   Aoyama, Toshifumi
   Tanaka, Naoki
TI Dietary Restriction Suppresses Steatosis-Associated Hepatic
   Tumorigenesis in Hepatitis C Virus Core Gene Transgenic Mice
SO LIVER CANCER
LA English
DT Article
DE NF-kappa B; STAT3; Cyclin D1; p62/SQSTM1; Senescence
ID ACTIVATED-RECEPTOR-ALPHA; FATTY LIVER-DISEASE; HEPATOCELLULAR-CARCINOMA;
   GROWTH-FACTOR; CALORIE RESTRICTION; KAPPA-B; PROTEIN; PROGRESSION;
   EXPRESSION; OVEREXPRESSION
AB Background and Aims: Dietary restriction (DR) is a preventive strategy for obesity, metabolic syndrome, cardiovascular disease, and diabetes. Although an interconnection between obesity, metabolic syndrome, fatty liver, and hepatocellular carcinoma has been documented, the mechanism and impact of DR on steatosis-derived hepatocarcinogenesis are not fully understood. This study aimed to evaluate whether DR can prevent hepatic tumorigenesis. Methods: Male hepatitis C virus core gene transgenic (HCVcpTg) mice that develop spontaneous age-dependent insulin resistance, hepatic steatosis, and ensuing liver tumor development without apparent hepatic fibrosis, were fed with either a control diet ad libitum (control group) or 70% of the same control diet (DR group) for 15 months, and liver phenotypes were investigated. Results: DR significantly reduced the number and volume of liver tumors. DR attenuated hepatic oxidative and endoplasmic reticulum stress and markedly suppressed nuclear factor-kappa B, signal transducer and activator of transcription 3 (STAT3) and STAT5, and phosphorylation of extracellular signal-regulated kinase, leading to downregulation of several pro-oncogenic mediators, such as cyclin D1. Serum insulin and insulin-like growth factor 1 levels, as well as hepatic expression of insulin receptor substrate 1/2, phosphatidylinositol-3 kinase, and serine/threonine-protein kinase AKT, were downregulated by DR. A transcriptome analysis revealed that STAT3 signaling and lipogenesis were the most suppressed hepatocarcinogenic pathways affected by DR. Additionally, DR stimulated autophagy and p62/sequestosome 1 degradation, enhanced phosphorylation of AMP-activated protein kinase alpha, increased fibroblast growth factor 21 expression, and attenuated expression of senescence-associated secretory phenotypes. Conclusion: DR suppressed steatosis-associated hepatic tumorigenesis in HCVcpTg mice, mainly due to attenuation of pathways involved in inflammation, cellular stress, cell proliferation, insulin signaling, and senescence. These findings support the notion that persistent 30% reduction of daily food intake is beneficial for preventing steatosis-associated hepatocarcinogenesis caused by HCV core protein. (c) 2020 The Author(s) Published by S. Karger AG, Basel
C1 [Jia, Fangping; Diao, Pan; Wang, Xiaojing; Hu, Xiao; Nakamura, Ibuki; Shirotori, Saki; Aoyama, Toshifumi; Tanaka, Naoki] Shinshu Univ, Dept Metab Regulat, Sch Med, Asahi 3-1-1, Matsumoto, Nagano 3908621, Japan.
   [Wang, Xiaojing] Zhejiang Univ, Lishui Hosp, Dept Gastroenterol, Sch Med, Lishui, Peoples R China.
   [Hu, Xiao] Hebei Med Univ, Dept Pathophysiol, Shjiazhuang, Peoples R China.
   [Kimura, Takefumi] Shinshu Univ, Dept Gastroenterol, Sch Med, Matsumoto, Nagano, Japan.
   [Nakamuta, Makoto] Kyushu Med Ctr, Dept Gastroenterol, Fukuoka, Japan.
   [Sato, Yoshiko; Nakayama, Jun] Shinshu Univ, Dept Mol Pathol, Sch Med, Matsumoto, Nagano, Japan.
   [Moriya, Kyoji] Univ Tokyo, Dept Infect Control & Prevent, Tokyo, Japan.
   [Koike, Kazuhiko] Univ Tokyo, Dept Gastroenterol, Tokyo, Japan.
   [Gonzalez, Frank J.] NCI, Lab Metab, NIH, Bethesda, MD 20892 USA.
   [Tanaka, Naoki] Shinshu Univ, Res Ctr Social Syst, Matsumoto, Nagano, Japan.
C3 Shinshu University; Zhejiang University; Hebei Medical University;
   Shinshu University; Shinshu University; University of Tokyo; University
   of Tokyo; National Institutes of Health (NIH) - USA; NIH National Cancer
   Institute (NCI); Shinshu University
RP Tanaka, N (corresponding author), Shinshu Univ, Dept Metab Regulat, Sch Med, Asahi 3-1-1, Matsumoto, Nagano 3908621, Japan.
EM naopi@shinshu-u.ac.jp
RI Wang, Xiaojing/HNI-4384-2023; Gonzalez, Francisco/GWV-3999-2022; Kimura,
   Takefumi/D-3412-2011
OI xiaojing, Wang/0000-0001-6921-3619; Gonzalez, Frank/0000-0002-7990-2140;
   Tanaka, Naoki/0000-0002-3212-3836; Kimura, Takefumi/0000-0002-1481-1029
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NR 53
TC 15
Z9 16
U1 0
U2 7
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 2235-1795
EI 1664-5553
J9 LIVER CANCER
JI Liver Cancer
PD SEP
PY 2020
VL 9
IS 5
BP 529
EP 548
DI 10.1159/000508308
PG 20
WC Oncology; Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Gastroenterology & Hepatology
GA NS9AS
UT WOS:000572548100005
PM 33083279
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Cheng, SB
   Sharma, S
AF Cheng, Shi-Bin
   Sharma, Surendra
TI Preeclampsia and health risks later in life: an immunological link
SO SEMINARS IN IMMUNOPATHOLOGY
LA English
DT Review
DE Preeclampsia; Inflammation; Immune tolerance; NK cells; Regulatory T
   cells; Microparticles; Aggregated proteins; Damage-associated molecular
   patterns; Chronic diseases
ID REGULATORY T-CELLS; NORMAL HUMAN-PREGNANCY; NATURAL-KILLER-CELLS;
   UTERINE NK CELLS; QUANTITATIVE-ANALYSIS; VASCULAR DYSFUNCTION; PROTEIN
   AGGREGATION; MITOCHONDRIAL-DNA; ACUTE ATHEROSIS; IMMUNE-SYSTEM
AB Pregnancy represents a period of physiological stress, and although this stress is experienced for a very modest portion of life, it is now recognized as a window to women's future health, often by unmasking predispositions to conditions that only become symptomatic later in life. In normal pregnancy, the mother experiences mild metabolic syndrome-like condition through week 20 of gestation. A pronounced phenotype of metabolic syndrome may program pregnancy complications such as preeclampsia. Preeclampsia is a serious complication with a myriad of manifestations for mother and offspring. This pregnancy syndrome is a polygenic disease and has been now linked to higher incidence of cardiovascular disease, diabetes, and several other disorders associated with vulnerable organs. Furthermore, the offspring born to preeclamptic mothers also exhibit an elevated risk of cardiovascular disease, stroke, and mental disorders during adulthood. This suggests that preeclampsia not only exposes the mother and the fetus to complications during pregnancy but also programs chronic diseases in later life. The etiology of preeclampsia is thought to be primarily associated with poor placentation and entails excessive maternal inflammation and endothelial dysfunction. It is well established now that the maternal immune system and the placenta are involved in a highly choreographed cross-talk that underlies adequate spiral artery remodeling required for uteroplacental perfusion and free flow of nutrients to the fetus. Since normal pregnancy is associated with a sequence of events represented by temporal events of inflammation (implantation), anti-inflammation (gestation), and inflammation (parturition), it is quite possible that unscheduled alterations in these regulatory responses may lead to pathologic consequences. Although it is not clear whether immunological alterations occur early in pregnancy, it is proposed that dysregulated systemic and placental immunity contribute to impaired angiogenesis and the onset of preeclampsia. This review will focus on important aspects of the immune system that coordinate with placental dysfunction to program preeclampsia and influence health in later life.
C1 [Cheng, Shi-Bin; Sharma, Surendra] Brown Univ, Women & Infants Hosp Rhode Isl, Dept Pediat, Warren Alpert Med Sch, 101 Dudley St, Providence, RI 02905 USA.
C3 Women & Infants Hospital Rhode Island; Brown University
RP Sharma, S (corresponding author), Brown Univ, Women & Infants Hosp Rhode Isl, Dept Pediat, Warren Alpert Med Sch, 101 Dudley St, Providence, RI 02905 USA.
EM ssharma@wihri.org
RI SAITO, SHIGERU/JXO-0004-2024
OI Cheng, Shibin/0000-0003-4911-6234
FU NIH [P30 GM114750]; Brown University DEANS Award; Constance Howes Award
   for Women's Health
FX This work was supported in part by a grant from NIH P30 GM114750, Brown
   University DEANS Award, and Constance Howes Award for Women's Health.
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NR 99
TC 67
Z9 68
U1 1
U2 16
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1863-2297
EI 1863-2300
J9 SEMIN IMMUNOPATHOL
JI Semin. Immunopathol.
PD NOV
PY 2016
VL 38
IS 6
BP 699
EP 708
DI 10.1007/s00281-016-0579-8
PG 10
WC Immunology; Pathology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Pathology
GA EA2MY
UT WOS:000386429000006
PM 27339196
DA 2025-06-11
ER

PT J
AU Vidovic, B
   Milovanovic, S
   Dordevic, B
   Kotur-Stevuljevic, J
   Stefanovic, A
   Ivanisevic, J
   Miljkovic, M
   Spasic, S
   Stojanovic, D
   Pantovic, M
AF Vidovic, Bojana
   Milovanovic, Srdan
   Dordevic, Brizita
   Kotur-Stevuljevic, Jelena
   Stefanovic, Aleksandra
   Ivanisevic, Jasmina
   Miljkovic, Milica
   Spasic, Slavica
   Stojanovic, Dragana
   Pantovic, Maja
TI EFFECT OF ALPHA-LIPOIC ACID SUPPLEMENTATION ON OXIDATIVE STRESS MARKERS
   AND ANTIOXIDATIVE DEFENSE IN PATIENTS WITH SCHIZOPHRENIA
SO PSYCHIATRIA DANUBINA
LA English
DT Article
DE alpha-lipoic acid; oxidative stress; antioxidative defence;
   schizophrenia
ID LIPID-PEROXIDATION; METABOLIC SYNDROME; WEIGHT-REDUCTION; PLASMA;
   PATHOPHYSIOLOGY; PREVENTION; PRODUCTS; CAPACITY; OBESITY; DRUG
AB Background: The purpose of this study was to examine the effects of alpha-lipoic acid (LA) supplementation on oxidative stress markers in patients with schizophrenia.
   Subjects and methods: Eighteen (18) medicated patients with schizophrenia and 38 healthy controls received daily supplements of LA (500 mg/day) for three months. At baseline, 45th and 90th days of supplementation, venous blood collected for analysis of oxidative stress markers [superoxide anion (O-2(center dot-)), thiobarbituric acid-reactive substances (TBARS) and advanced oxidation protein products (AOPP)] and antioxidative defense markers [superoxide dismutase (SOD), total sulfhydryl groups (-SH) and total antioxidant status (TAS)].
   Results: Increased plasma TBARS, TAS, SH groups levels and SOD activity were found in schizophrenic patients compared to control group. LA supplementation significantly reduced TBARS, AOPP and improved TAS levels in healthy subjects, while there were no significant differences in patients group. SH groups increased after 45 days and decreased to baseline levels after 90 days of supplementation in the control group. SOD activity decreased significantly in patients group after 45 days and 90 days of supplementation. After initial rose SOD activity in control group, decreased to baseline levels found after 90 days.
   Conclusion: LA supplementation decreased lipid peroxidation and oxidative damage of proteins and improved non-enzymatic antioxidant capacity in healthy controls. No significant changes were observed on oxidative damage in patients with schizophrenia.
C1 [Vidovic, Bojana; Dordevic, Brizita] Univ Belgrade, Fac Pharm, Dept Bromatol, Belgrade, Serbia.
   [Milovanovic, Srdan] Univ Belgrade, Fac Med, Belgrade, Serbia.
   [Milovanovic, Srdan; Stojanovic, Dragana; Pantovic, Maja] Clin Ctr Serbia, Psychiat Clin, Belgrade 11000, Serbia.
   [Kotur-Stevuljevic, Jelena; Stefanovic, Aleksandra; Ivanisevic, Jasmina; Miljkovic, Milica; Spasic, Slavica] Univ Belgrade, Dept Med Biochem, Fac Pharm, Belgrade, Serbia.
C3 University of Belgrade; University of Belgrade; Clinical Centre of
   Serbia; University of Belgrade
RP Milovanovic, S (corresponding author), Clin Ctr Serbia, Psychiat Clin, Pasterova 2, Belgrade 11000, Serbia.
EM dr.srle@eunet.rs
RI Djordjevic, Brizita/V-5590-2017; Vidovic, Bojana/S-2370-2017
OI Vidovic, Bojana/0000-0001-6644-6230; Milovanovic,
   Srdjan/0000-0003-2516-0783; Stefanovic, Aleksandra/0000-0002-0331-6807;
   Stojanovic, Dusica/0000-0002-7907-3311; Pantovic Stefanovic,
   Maja/0000-0002-2263-0885
FU Serbian Ministry of Education, Science and Technological Development
   [III 46001, 175035]
FX This work was financially supported by grants from the Serbian Ministry
   of Education, Science and Technological Development (Project number III
   46001 and 175035).
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NR 51
TC 37
Z9 39
U1 0
U2 5
PU MEDICINSKA NAKLADA
PI ZAGREB
PA VLASKA 69, HR-10000 ZAGREB, CROATIA
SN 0353-5053
J9 PSYCHIAT DANUB
JI Psychiatr. Danub.
PY 2014
VL 26
IS 3
BP 205
EP 213
PG 9
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA AW2WL
UT WOS:000346147300002
PM 25191766
DA 2025-06-11
ER

PT J
AU Guru, A
   Velayutham, M
   Arockiaraj, J
AF Guru, Ajay
   Velayutham, Manikandan
   Arockiaraj, Jesu
TI Lipid-Lowering and Antioxidant Activity of RF13 Peptide From Vacuolar
   Protein Sorting-Associated Protein 26B (VPS26B) by Modulating Lipid
   Metabolism and Oxidative Stress in HFD Induced Obesity in Zebrafish
   Larvae
SO INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS
LA English
DT Article
DE Vacuolar protein sorting-associated protein; Lipid accumulation;
   Antioxidant; Zebrafish; High fat diet
ID HIGH-FAT DIET; GENE-EXPRESSION; INDUCED HYPERLIPIDEMIA; NITRIC-OXIDE;
   L-ARGININE; ACCUMULATION; CELLS; ADIPOGENESIS; TOXICITY
AB Obesity is one of the major contributing factors responsible for the onset of various metabolic syndrome. In obesity-related metabolic syndrome, increased oxidative stress in accumulated fat is a key pathogenic mechanism. The aim of this study is to investigate the lipid-lowering and antioxidant effects of RF13 peptide derived from vacuolar protein sorting associated protein 26B (VPS26B) in high fat diet (HFD) induced zebrafish larvae. Based on the arrangement, composition, and bioinformatics analysis of the VPS26B protein sequence, we predicted and synthesized a short peptide, (1)RRGKGGRRVTMSF(13) (RF13). In vitro analysis (DPPH, ABTS and nitric oxide assay) of RF13 on showed its potential antioxidant properties and radical scavenging capacity. Rat skeletal muscle cells (L6) and human erythrocyte cells are used for the evaluation of RF13 cytotoxicity at differing concentrations showed no cytotoxic effect. Zebrafish larvae feeding HFD, on day 4 post fertilization (dpf) to 6 dpf, there was an increase in production of reactive oxygen species (ROS) and lipid accumulation, which showed decreased expression of antioxidative enzymes such as glutathione S-transferase (GST), glutathione reductase (GR) and glutathione peroxidase (GPx). However, RF13 treatment has significantly reduced the total cholesterol and triglycerides levels, enhanced antioxidant enzyme levels, and decreased lipid peroxidation. In addition, RF13 treatment has significantly decreased lipid accumulation, intracellular ROS and apoptosis in zebrafish larvae as compared to the HFD group. Furthermore, RF13 significantly downregulated the lipid metabolizing genes such as CCAAT/enhancer-binding protein-alpha (C/EBP-alpha), sterol regulatory element-binding protein 1 (SREBP1) and fatty acid synthase (FAS), while they upregulated the antioxidant-related genes. These results suggests that RF13 peptides can be used as functional foods and natural drugs to enhance the antioxidant ability and also to alleviate lipid accumulation by regulating lipid metabolism.
C1 [Guru, Ajay; Velayutham, Manikandan; Arockiaraj, Jesu] SRM Inst Sci & Technol, Coll Sci & Humanities, Dept Biotechnol, Chennai 603203, Tamil Nadu, India.
   [Arockiaraj, Jesu] Fdn Aquaculture Innovat & Technol Transfer FAITT, Chennai 600097, Tamil Nadu, India.
C3 SRM Institute of Science & Technology Chennai
RP Arockiaraj, J (corresponding author), SRM Inst Sci & Technol, Coll Sci & Humanities, Dept Biotechnol, Chennai 603203, Tamil Nadu, India.; Arockiaraj, J (corresponding author), Fdn Aquaculture Innovat & Technol Transfer FAITT, Chennai 600097, Tamil Nadu, India.
EM jesuaraj@hotmail.com
RI Guru, Ajay/JFJ-2008-2023; Arockiaraj, Jesu/A-6227-2013; Velayutham,
   Manikandan/CAG-0985-2022
OI Velayutham, Manikandan/0000-0002-1128-8308; Guru,
   Ajay/0000-0002-8583-9352
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NR 65
TC 38
Z9 39
U1 7
U2 39
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1573-3149
EI 1573-3904
J9 INT J PEPT RES THER
JI Int. J. Pept. Res. Ther.
PD MAR
PY 2022
VL 28
IS 2
AR 74
DI 10.1007/s10989-022-10376-3
PG 15
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA ZL9YF
UT WOS:000764023800001
DA 2025-06-11
ER

PT J
AU Apaijai, N
   Arinno, A
   Palee, S
   Pratchayasakul, W
   Kerdphoo, S
   Jaiwongkam, T
   Chunchai, T
   Chattipakorn, SC
   Chattipakorn, N
AF Apaijai, Nattayaporn
   Arinno, Apiwan
   Palee, Siripong
   Pratchayasakul, Wasana
   Kerdphoo, Sasiwan
   Jaiwongkam, Thidarat
   Chunchai, Titikorn
   Chattipakorn, Siriporn C.
   Chattipakorn, Nipon
TI High-Saturated Fat High-Sugar Diet Accelerates Left-Ventricular
   Dysfunction Faster than High-Saturated Fat Diet Alone via Increasing
   Oxidative Stress and Apoptosis in Obese-Insulin Resistant Rats
SO MOLECULAR NUTRITION & FOOD RESEARCH
LA English
DT Article
DE heart; high-saturated fat diet; high-saturated fat high-sugar diet;
   mitochondrial dynamics; mitochondrial function
ID HEART-RATE-VARIABILITY; MITOCHONDRIAL DYNAMICS; METABOLIC SYNDROME;
   VILDAGLIPTIN; GLUT4
AB Scope It has been hypothesized that a high-saturated-fat, high-sugar diet (HFHS) causes worse cardiometabolic dysfunction than a high-saturated-fat diet (HFD) due to severe mitochondrial dysfunction, oxidative stress, and apoptosis in obese insulin-resistant rats. Methods and Results Rats are divided into three groups to receive normal diet (ND), HFD, or HFHS for 24 weeks. Cardiometabolic parameters are determined at baseline and every 4 weeks until the end of the feeding protocol. At week 24, hearts are removed to determine mitochondrial function and dynamics, apoptosis, and insulin signaling. HFD and HFHS rats develop obese insulin-resistance at week 8. However, fasting plasma glucose level is increased only in HFHS rats. Myocardial insulin signaling is markedly impaired in HFHS rats compared to other groups. Cardiac autonomic imbalance is observed in both HFD and HFHS rats beginning at week 8. However, cardiac dysfunction is observed earlier (week 8) in HFHS rats, and later at week 12 in HFD rats. Moreover, cardiac and mitochondrial oxidative stress levels, and apoptosis are greater in HFHS rats than HFD rats. Conclusion Both HFD and HFHS cause cardiometabolic dysfunction. HFHS causes more severe metabolic disturbance, oxidative stress, and apoptosis than HFD, which leads to an accelerated LV dysfunction in HFHS rats.
C1 [Apaijai, Nattayaporn; Arinno, Apiwan; Palee, Siripong; Pratchayasakul, Wasana; Kerdphoo, Sasiwan; Jaiwongkam, Thidarat; Chunchai, Titikorn; Chattipakorn, Siriporn C.; Chattipakorn, Nipon] Chiang Mai Univ, Fac Med, Cardiac Electrophysiol Res & Training Ctr, Chiang Mai 50200, Thailand.
   [Apaijai, Nattayaporn; Arinno, Apiwan; Palee, Siripong; Pratchayasakul, Wasana; Kerdphoo, Sasiwan; Jaiwongkam, Thidarat; Chunchai, Titikorn; Chattipakorn, Siriporn C.; Chattipakorn, Nipon] Chiang Mai Univ, Ctr Excellence Cardiac Electrophysiol Res, Chiang Mai 50200, Thailand.
   [Chunchai, Titikorn; Chattipakorn, Nipon] Chiang Mai Univ, Fac Med, Cardiac Electrophysiol Unit, Dept Physiol, Chiang Mai 50200, Thailand.
   [Chattipakorn, Siriporn C.] Chiang Mai Univ, Dept Oral Biol & Diagnost Sci, Fac Dent, Chiang Mai 50200, Thailand.
C3 Chiang Mai University; Chiang Mai University; Chiang Mai University;
   Chiang Mai University
RP Chattipakorn, N (corresponding author), Chiang Mai Univ, Fac Med, Cardiac Electrophysiol Res & Training Ctr, Chiang Mai 50200, Thailand.; Chattipakorn, N (corresponding author), Chiang Mai Univ, Ctr Excellence Cardiac Electrophysiol Res, Chiang Mai 50200, Thailand.; Chattipakorn, N (corresponding author), Chiang Mai Univ, Fac Med, Cardiac Electrophysiol Unit, Dept Physiol, Chiang Mai 50200, Thailand.
EM nchattip@gmail.com
RI Chattipakorn, Nipon/AAJ-4049-2021; PALEE, SIRIPONG/ABD-8607-2021
OI Clements, Thomas W/0000-0002-0278-5660; Chunchai,
   Titikorn/0000-0003-4405-1208; Chattipakorn, Siriporn/0000-0003-1677-7052
FU Thailand Research Fund [TRF-RTA6080003, TRG-6080005, RSA-6180056,
   RSA-6180071]; Royal Golden Jubilee PhD program [PHD/0146/2558]; Faculty
   of Medicine, Chiang Mai University Endowment Fund [073/2560]; NSTDA
   Research Chair grant from the National Science and Technology
   Development Agency Thailand; Chiang Mai University Center of Excellence
   Award
FX S.C.C. and N.C. conceived and designed the experiments. N.A., A. A.,
   S.P., W.P., S.K., T.J., and T.C. performed the experiments. N.A.,
   S.C.C., and N.C. analyzed the data. S.C.C. and N.C. contributed
   reagents, materials, and analysis tools. N.A., S.C.C., and N.C. wrote
   the paper. This work was supported by Thailand Research Fund grants:
   TRF-RTA6080003 (S.C.C.), TRG-6080005 (N.A.), RSA-6180056 (S.P.),
   RSA-6180071 (W.P.) the Royal Golden Jubilee PhD program (PHD/0146/2558
   T.C. and S.C.C.), a Faculty of Medicine, Chiang Mai University Endowment
   Fund (073/2560 N.A.), a NSTDA Research Chair grant from the National
   Science and Technology Development Agency Thailand (N.C.), and Chiang
   Mai University Center of Excellence Award (N.C.).
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NR 44
TC 16
Z9 16
U1 0
U2 16
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1613-4125
EI 1613-4133
J9 MOL NUTR FOOD RES
JI Mol. Nutr. Food Res.
PD JAN
PY 2019
VL 63
IS 2
AR 1800729
DI 10.1002/mnfr.201800729
PG 12
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA HI8KZ
UT WOS:000456706100011
PM 30411851
DA 2025-06-11
ER

PT J
AU Pons, Z
   Guerrero, L
   Margalef, M
   Arola, L
   Arola-Arnal, A
   Muguerza, B
AF Pons, Z.
   Guerrero, L.
   Margalef, M.
   Arola, L.
   Arola-Arnal, A.
   Muguerza, B.
TI Effect of low molecular grape seed proanthocyanidins on blood pressure
   and lipid homeostasis in cafeteria diet-fed rats
SO JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
LA English
DT Article; Proceedings Paper
CT 10th Meeting of the Contribution To Progress in Obesity and Diabetes
   Research (CTPIOD)
CY MAY 22, 2013
CL Reus, SPAIN
DE Cardiovascular disease; Flavonoids; Grape proanthocyanidins;
   Hypertension; Dyslipidaemia; Oxidative stress
ID AT1-TYPE ANGIOTENSIN RECEPTOR; CORONARY-HEART-DISEASE; EGG-WHITE
   HYDROLYSATE; LONG-TERM INTAKE; METABOLIC SYNDROME; OXIDATIVE STRESS;
   PROCYANIDINS; RISK; HYPERTENSION; RICH
AB Cardiovascular disease (CVD) and related pathologies are the leading cause of death worldwide. Fruits and vegetables are known to improve CVD, an effect that has been associated with flavonoid intake. The aim of this study was to simultaneously evaluate the acute effect of a low molecular grape seed proanthocyanidin extract (LM-GSPE) on two of the main risk factors of CVD, high blood pressure (BP) and dyslipidaemia, using high-fat diet-fed rats. Therefore, male Wistar rats that were cafeteria diet fed for 10 weeks were administered with 375 mg/kg of body weight of LM-GSPE, and the BP as well as plasmatic and hepatic parameters were determined at 6 h post-administration. The BP and plasmatic and hepatic lipid were decreased 6 h after the LM-GSPE administration. Moreover, the liver lipid peroxidation products decreased after the LM-GSPE treatment, indicating a reduction in oxidative stress. However, hepatic-reduced glutathione or plasma angiotensin converting enzyme activity was not altered by the LM-GSPE. In conclusion, grape proanthocyanidins is able to simultaneously reduce more than one risk factor for CVD by decreasing the BP and improving hypertriglyceridaemia at least in part due to an improvement in oxidative stress. These results open up the possibility of using grape proanthocyanidins in functional foods for CVD improvement.
C1 [Pons, Z.; Guerrero, L.; Margalef, M.; Arola, L.; Arola-Arnal, A.; Muguerza, B.] Univ Rovira & Virgili, Dept Biochem & Biotechnol, E-43007 Tarragona, Spain.
   [Guerrero, L.] ALPINA SA, Dept Res Nutr & Innovat, Bogota, Colombia.
   [Arola, L.; Muguerza, B.] CEICS, TECNIO, CTNS, Reus, Catalonia, Spain.
C3 Universitat Rovira i Virgili
RP Arola-Arnal, A (corresponding author), Univ Rovira & Virgili, Dept Biochem & Biotechnol, C Marcel Li Domingo S-N, E-43007 Tarragona, Spain.
EM anna.arola@urv.cat
RI Muguerza, Begoña/AAT-3544-2021; Arola-Arnal, Anna/C-2087-2015; Margalef,
   Maria/E-9501-2018; Arola, Lluis/C-6074-2011; Muguerza,
   Begona/C-6704-2015
OI Arola-Arnal, Anna/0000-0001-6529-1345; Margalef,
   Maria/0000-0001-7932-9770; Arola, Lluis/0000-0003-2767-1974; Muguerza,
   Begona/0000-0001-7384-8588; Pons Vila, Zara/0000-0003-0122-2556
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NR 69
TC 47
Z9 55
U1 0
U2 49
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1138-7548
EI 1877-8755
J9 J PHYSIOL BIOCHEM
JI J. Physiol. Biochem.
PD JUN
PY 2014
VL 70
IS 2
BP 629
EP 637
DI 10.1007/s13105-014-0329-0
PG 9
WC Biochemistry & Molecular Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Biochemistry & Molecular Biology; Physiology
GA AG4GN
UT WOS:000335377500032
PM 24610672
DA 2025-06-11
ER

PT J
AU Figueiredo, VP
   Barbosa, MA
   de Castro, UGM
   Zacarias, AC
   Bezerra, FS
   de Sá, RG
   de Lima, WG
   dos Santos, RAS
   Alzamora, AC
AF Figueiredo, Vivian Paulino
   Barbosa, Maria Andrea
   Mendes de Castro, Uberdan Guilherme
   Zacarias, Aline Cruz
   Bezerra, Frank Silva
   de Sa, Renata Guerra
   de Lima, Wanderson Geraldo
   Souza dos Santos, Robson Augusto
   Alzamora, Andreia Carvalho
TI Antioxidant Effects of Oral Ang-(1-7) Restore Insulin Pathway and RAS
   Components Ameliorating Cardiometabolic Disturbances in Rats
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Article
ID OXIDATIVE STRESS; SENSITIVITY; FORMULATION; METABOLISM; RESISTANCE;
   MUSCLE; DIET; AXIS
AB In prevention studies of metabolic syndrome (MetS), Ang-(1-7) has shown to improve the insulin signaling. We evaluated the HP beta CD/Ang-(1-7) treatment on lipid metabolism, renin-angiotensin system (RAS) components, oxidative stress, and insulin pathway in the liver and gastrocnemius muscle and hepatic steatosis in rats with established MetS. After 7 weeks of high-fat (FAT) or control (CT) diets, rats were treated with cyclodextrin (HP beta CD) or HP beta CD/Ang-(1-7) in the last 6 weeks. FAT-HP beta CD/empty rats showed increased adiposity index and body mass, gene expression of ACE/ANG II/AT1R axis, and oxidative stress. These results were accompanied by imbalances in the insulin pathway, worsening of liver function, hyperglycemia, and dyslipidemia. Oral HP beta CD/Ang-(1-7) treatment decreased ACE and AT1R, increased ACE2 gene expression in the liver, and restored thiobarbituric acid reactive substances (TBARS), catalase (CAT), superoxide dismutase (SOD), insulin receptor substrate (Irs-1), glucose transporter type 4 (GLUT4), and serine/threonine kinase 2 (AKT-2) gene expression in the liver and gastrocnemius muscle improving hepatic function, cholesterol levels, and hyperglycemia in MetS rats. Overall, HP beta CD/Ang-(1-7) treatment restored the RAS components, oxidative stress, and insulin signaling in the liver and gastrocnemius muscle contributing to the establishment of blood glucose and lipid homeostasis in MetS rats.
C1 [Figueiredo, Vivian Paulino; Barbosa, Maria Andrea; Mendes de Castro, Uberdan Guilherme; Zacarias, Aline Cruz; Bezerra, Frank Silva; de Sa, Renata Guerra; de Lima, Wanderson Geraldo; Alzamora, Andreia Carvalho] Univ Fed Ouro Preto, NUPEP, Ouro Preto, MG, Brazil.
   [Bezerra, Frank Silva; de Sa, Renata Guerra; de Lima, Wanderson Geraldo; Alzamora, Andreia Carvalho] Inst Ciencias Exatas & Biol, Dept Ciencias Biol, Ouro Preto, MG, Brazil.
   [Souza dos Santos, Robson Augusto] Univ Fed Minas Gerais, Dept Fisiol & Biofis, Belo Horizonte, MG, Brazil.
C3 Universidade Federal de Ouro Preto; Universidade Federal de Minas Gerais
RP Alzamora, AC (corresponding author), Univ Fed Ouro Preto, NUPEP, Ouro Preto, MG, Brazil.; Alzamora, AC (corresponding author), Inst Ciencias Exatas & Biol, Dept Ciencias Biol, Ouro Preto, MG, Brazil.
EM andreiaalzamora@uol.com.br
RI Bezerra, Frank/AAD-1233-2019; Lima, Wanderson/Y-7198-2019; Santos,
   Robson/C-9336-2011
OI Zacarias, Aline Cruz/0000-0002-2574-1775; Lima,
   Wanderson/0000-0001-9844-3472; Bezerra, Frank/0000-0002-0804-5196;
   Santos, Robson/0000-0001-8738-5852
FU Universidade Federal de Ouro Preto (UFOP); CBIOL-UFOP; NUPEB-UFOP;
   Fundacao de Amparo a Pesquisa do Estado de Minas Gerais (FAPEMIG);
   Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq);
   Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES);
   UFOP fellowship (Postdoctoral) in the Programa de Pos-Graduacao em
   Ciencias Biologicas, UFOP
FX This study was supported by the Universidade Federal de Ouro Preto
   (UFOP), CBIOL-UFOP, NUPEB-UFOP, Fundacao de Amparo a Pesquisa do Estado
   de Minas Gerais (FAPEMIG), Conselho Nacional de Desenvolvimento
   Cientifico e Tecnologico (CNPq), and Coordenacao de Aperfeicoamento de
   Pessoal de Nivel Superior (CAPES). Vivian Paulino Figueiredo received a
   UFOP fellowship (Postdoctoral) in the Programa de Pos-Graduacao em
   Ciencias Biologicas, UFOP.
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NR 30
TC 18
Z9 20
U1 1
U2 5
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PD JUL 14
PY 2019
VL 2019
AR 5868935
DI 10.1155/2019/5868935
PG 10
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA JH8DH
UT WOS:000492998400001
PM 31396301
OA Green Submitted, Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Charradi, K
   Mahmoudi, M
   Elkahoui, S
   Limam, F
   Aouani, E
AF Charradi, Kamel
   Mahmoudi, Mohamed
   Elkahoui, Salem
   Limam, Ferid
   Aouani, Ezzedine
TI Grape seed and skin extract mitigates heart and liver oxidative damage
   induced by a high-fat diet in the rat: gender dependency
SO CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
LA English
DT Article
DE gender; grape seed and skin; obesity; oxidative stress
ID ESTROGEN-RECEPTOR-ALPHA; INDUCED OBESITY; SUPEROXIDE-DISMUTASE;
   RESVERATROL; EXPRESSION; APOPTOSIS; ISCHEMIA; CALPAIN; DISEASE; STRESS
AB Obesity is a public health problem contributing to morbidity and mortality from metabolic syndrome. It has long been recognized that there is a gender dependency in several obesity-related health risks. Using a high fat diet (HFD) to induce obesity in Wistar rats, we studied the gender dependency of fat-induced oxidative stress in the heart and liver, with a special emphasis on the distribution of transition metals, as well as the protective effects of grape seed and skin extract (GSSE). HFD induced obesity in both male and female rats, characterized by increased body weight as well as relative liver mass in both genders, and increased relative heart mass in the males only. HFD also provoked the accumulation of triglycerides and total cholesterol into the male hearts, and into the livers of both genders. HFD induced oxidative stress in the male hearts and also in the livers of both genders. Furthermore, HFD affected cardiac levels of copper in the males, and hepatic levels of copper and zinc in both genders, whereas HFD affected free iron in the male hearts and female livers, specifically. In conclusion, HFD treatment altered transition metal homeostasis more drastically in the male heart than in the female liver, and GSSE efficiently protected these organs against fat-induced disturbances, regardless of gender.
C1 [Charradi, Kamel; Mahmoudi, Mohamed; Elkahoui, Salem; Limam, Ferid; Aouani, Ezzedine] Ctr Biotechnol Borj Cedria, Lab Subst Bioact LSBA, Hammam Lif 2050, Tunisia.
   [Charradi, Kamel; Mahmoudi, Mohamed; Aouani, Ezzedine] Univ Carthage, Fac Sci Bizerte, Jarzouna 7021, Tunisia.
C3 Centre de Biotechnologie de Borj Cedria; Universite de Carthage
RP Charradi, K (corresponding author), Ctr Biotechnol Borj Cedria, Lab Subst Bioact LSBA, BP 901, Hammam Lif 2050, Tunisia.
EM charradi3@yahoo.com
RI Charradi, Kamel/AAR-8778-2021; ELKAHOUI, Salem/AAR-6542-2021
OI ELKAHOUI, SALEM/0000-0001-5577-1011
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NR 54
TC 19
Z9 19
U1 0
U2 14
PU CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS
PI OTTAWA
PA 65 AURIGA DR, SUITE 203, OTTAWA, ON K2E 7W6, CANADA
SN 0008-4212
EI 1205-7541
J9 CAN J PHYSIOL PHARM
JI Can. J. Physiol. Pharmacol.
PD DEC
PY 2013
VL 91
IS 12
BP 1076
EP 1085
DI 10.1139/cjpp-2013-0225
PG 10
WC Pharmacology & Pharmacy; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Physiology
GA 262XU
UT WOS:000327772000012
PM 24289079
DA 2025-06-11
ER

PT J
AU Tadmor, H
   Golani, I
   Doron, R
   Kremer, I
   Shamir, A
AF Tadmor, Hagar
   Golani, Idit
   Doron, Ravid
   Kremer, Ilana
   Shamir, Alon
TI ErbB signaling antagonist ameliorates behavioral deficit induced by
   phencyclidine (PCP) in mice, without affecting metabolic syndrome
   markers
SO PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
LA English
DT Article
DE Schizophrenia; ErbB signaling; Animal models; Metabolic markers;
   Phencyclidine; Antipsychotic drugs
ID EPIDERMAL-GROWTH-FACTOR; DOPAMINE HYPOTHESIS; MILD STRESS;
   SCHIZOPHRENIA; NEUREGULIN-1; EXPRESSION; CLOZAPINE; MODEL; RECEPTOR;
   COGNITION
AB Schizophrenia is a severe syndrome that affects about 1% of the world population. Since the mid-1950s, antipsychotics have been used to treat schizophrenia with preference for treating positive symptoms; however, their tolerance level is low, there are numerous side effects, and only some patients respond to the treatment. Antipsychotic medications that are more effective, better tolerated, and with fewer adverse effects are urgently needed. Given the accumulating evidence of the role filled by the ErbB signaling network in the biology of the dopamine, GABA, and glutamate systems, and in the etiology of schizophrenia, we hypothesized that the ErbB network is a candidate for development of a novel agent through which various symptoms of schizophrenia and other psychiatric disorders might be treated.
   Herein, we studied, in mice, the capability of blocking the ErbB signaling, in comparison with the atypical antipsychotic drug clozapine, to counter schizophrenia-like behavior induced by acute and sub-chronic phencyclidine (PCP), and determined whether inhibition of the ErbB networks induced weight gain and affected social and exploratory behavior, and metabolic syndrome markers. We demonstrated that administration of the pan-ErbB inhibitor JNJ28871063 (JNJ) reduced the level of activity in the open field induced by an acute injection of PCP. Moreover, the ability of JNJ to attenuate the effect of PCP is as effective as clozapine. In addition and like clozapine, JNJ normalized social behavior impairment induced by sub-chronic PCP and stress. Adult JNJ-treated mice displayed normal sociability and exploratory behavior, and their serum cholesterol, LDL, and HDL levels were lower than in the saline-treated mice. Sub-chronic treatment did not affect weight gain, glucose levels, and the activity of hepatic enzymes catalase and SOD.
   These data suggest that treatment with JNJ attenuates abnormal behaviors induced by PCP, and has similar effects as the antipsychotic drug clozapine, with no adverse effects. Thus, the ErbB signaling can serve as a new starting point for non-dopaminergic-based drug development of schizophrenia.
C1 [Tadmor, Hagar; Kremer, Ilana; Shamir, Alon] Mazor Mental Hlth Ctr, Psychobiol Res Lab, Akko, Israel.
   [Tadmor, Hagar] Bar Ilan Univ, Fac Med Galilee, Safed, Israel.
   [Golani, Idit] ORT Braude Coll, Dept Biotechnol, Karmiel, Israel.
   [Doron, Ravid] Acad Coll Tel Aviv Yaffo, Sch Behav Sci, Psychobiol Lab, Tel Aviv, Israel.
   [Doron, Ravid] Open Univ, Dept Educ & Psychol, Raanana, Israel.
   [Kremer, Ilana; Shamir, Alon] Technion Israel Inst Technol, Ruth & Bruce Rappaport Fac Med, Haifa, Israel.
C3 Bar Ilan University; Braude Academic College of Engineering; Open
   University Israel; Technion Israel Institute of Technology; Rappaport
   Faculty of Medicine
RP Shamir, A (corresponding author), Technion Israel Inst Technol, Ruth & Bruce Rappaport Fac Med, Mazor Mental Hlth Ctr, Psychobiol Res Lab, IL-25201 Dn Oshrat, Akko, Israel.
EM alons@mazor.health.gov.il
RI Shamir, Alon/HOF-5499-2023
FU Technion Israel Institute of Technology; Ort Braude College
FX This work was supported by the Technion Israel Institute of Technology
   (A.S) and Ort Braude College (I.G.).
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NR 68
TC 9
Z9 9
U1 0
U2 11
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0278-5846
EI 1878-4216
J9 PROG NEURO-PSYCHOPH
JI Prog. Neuro-Psychopharmacol. Biol. Psychiatry
PD MAR 2
PY 2018
VL 82
BP 322
EP 331
DI 10.1016/j.pnpbp.2017.08.010
PG 10
WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA FV6OT
UT WOS:000424701600033
PM 28818421
DA 2025-06-11
ER

PT J
AU Yamazaki, Y
   Usui, I
   Kanatani, Y
   Matsuya, Y
   Tsuneyama, K
   Fujisaka, S
   Bukhari, A
   Suzuki, H
   Senda, S
   Imanishi, S
   Hirata, K
   Ishiki, M
   Hayashi, R
   Urakaze, M
   Nemoto, H
   Kobayashi, M
   Tobe, K
AF Yamazaki, Yu
   Usui, Isao
   Kanatani, Yukiko
   Matsuya, Yuji
   Tsuneyama, Koichi
   Fujisaka, Shiho
   Bukhari, Agussalim
   Suzuki, Hikari
   Senda, Satoko
   Imanishi, Shingo
   Hirata, Kazuya
   Ishiki, Manabu
   Hayashi, Ryuji
   Urakaze, Masaharu
   Nemoto, Hideo
   Kobayashi, Masashi
   Tobe, Kazuyuki
TI Treatment with SRT1720, a SIRT1 activator, ameliorates fatty liver with
   reduced expression of lipogenic enzymes in MSG mice
SO AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
LA English
DT Article
DE nonalcoholic fatty liver disease; lipogenesis; beta-oxidation;
   monosodium glutamate
ID MONOSODIUM GLUTAMATE; METABOLIC SYNDROME; GENE-EXPRESSION;
   PROTEIN-KINASE; DISEASE; LONGEVITY; STEATOHEPATITIS; DEACETYLASES;
   MECHANISMS; OBESITY
AB Yamazaki Y, Usui I, Kanatani Y, Matsuya Y, Tsuneyama K, Fujisaka S, Bukhari A, Suzuki H, Senda S, Imanishi S, Hirata K, Ishiki M, Hayashi R, Urakaze M, Nemoto H, Kobayashi M, Tobe K. Treatment with SRT1720, a SIRT1 activator, ameliorates fatty liver with reduced expression of lipogenic enzymes in MSG mice. Am J Physiol Endocrinol Metab 297: E1179-E1186, 2009. First published September 1, 2009; doi: 10.1152/ajpendo.90997.2008.-Nonalcoholic fatty liver disease (NAFLD) is an abnormal liver metabolism often observed with insulin resistance and metabolic syndrome. Calorie restriction is a useful treatment for NAFLD and reportedly prolongs the life spans of several species in which sirtuin plays an important role. In this study, we examined whether the activation of SIRT1, a mammalian ortholog of sirtuin, may ameliorate the development of NAFLD. Monosodium glutamate (MSG) mice, which exhibited obesity and insulin resistance, were treated with SRT1720, a specific SIRT1 activator from the age of 6-16 wk. Sixteen-week-old MSG mice exhibited increased liver triglyceride content and elevated levels of aminotransferase. SRT1720 treatment significantly reduced these levels without affecting body weight or food intake. These results suggested that the administration of SRT1720 ameliorated the development of NAFLD in MSG mice. The expressions of lipogenic genes, such as sterol regulatory element-binding protein-1c, acetyl-CoA carboxylase, and fatty acid synthase, and the serum lipid profiles, including free fatty acids, were elevated in MSG mice and were reduced by SRT1720 treatment. SRT1720 treatment also reduced the expressions of lipogenic genes in cultured HepG2 cells. Furthermore, SRT1720 treatment decreased the expressions of marker genes for oxidative stress and inflammatory cytokines in the liver of MSG mice. Taken together, SRT1720 treatment may reduce liver lipid accumulation, at least in part, by directly reducing the expressions of lipogenic genes. The reduction of oxidative stress and inflammation may also be involved in the amelioration of NAFLD.
C1 [Yamazaki, Yu; Usui, Isao; Kanatani, Yukiko; Fujisaka, Shiho; Bukhari, Agussalim; Suzuki, Hikari; Senda, Satoko; Imanishi, Shingo; Hirata, Kazuya; Ishiki, Manabu; Hayashi, Ryuji; Urakaze, Masaharu; Tobe, Kazuyuki] Toyama Univ, Dept Internal Med 1, Toyama 9300194, Japan.
   [Matsuya, Yuji; Nemoto, Hideo] Toyama Univ, Grad Sch Med & Pharmaceut Sci, Toyama 9300194, Japan.
   [Tsuneyama, Koichi] Toyama Univ, Dept Diagnost Pathol, Toyama 9300194, Japan.
   [Kobayashi, Masashi] Toyama Univ, Univ Hosp, Toyama 9300194, Japan.
C3 University of Toyama; University of Toyama; University of Toyama;
   University of Toyama
RP Usui, I (corresponding author), Toyama Univ, Dept Internal Med 1, 2630 Sugitani, Toyama 9300194, Japan.
EM isaousui-tym@umin.ac.jp
RI Bukhari, Agussalim/R-9284-2019; Yamazaki, Yu/HSG-5881-2023
OI Bukhari, Agussalim/0000-0002-6340-8615; Tsuneyama,
   Koichi/0000-0002-0670-9868
FU Ministry of Education, Science, Sports, and Culture, Japan [18209033];
   Grants-in-Aid for Scientific Research [18209033] Funding Source: KAKEN
FX This work was supported by a Grant-in-Aid for Scientific Research from
   the Ministry of Education, Science, Sports, and Culture, Japan (18209033
   to K. Tobe).
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NR 30
TC 129
Z9 149
U1 1
U2 23
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0193-1849
EI 1522-1555
J9 AM J PHYSIOL-ENDOC M
JI Am. J. Physiol.-Endocrinol. Metab.
PD NOV
PY 2009
VL 297
IS 5
BP E1179
EP E1186
DI 10.1152/ajpendo.90997.2008
PG 8
WC Endocrinology & Metabolism; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Physiology
GA 509CL
UT WOS:000270990500024
PM 19724016
DA 2025-06-11
ER

PT J
AU Zhu, ZY
   Cao, T
   Chen, H
   Zhang, BK
   Lin, CQ
   Cai, HL
AF Zhu, ZhenYu
   Cao, Ting
   Chen, Hui
   Zhang, BiKui
   Lin, ChenQuan
   Cai, HuaLin
TI Olanzapine-induced nonalcoholic fatty liver disease: The effects of
   differential food pattern and the involvement of PGRMC1 signaling
SO FOOD AND CHEMICAL TOXICOLOGY
LA English
DT Article
DE Olanzapine; NAFLD; High fatty supplementation; PGRMC1; Lipid
   accumulation; Oxidative stress
ID MEMBRANE COMPONENT 1; INDUCED WEIGHT-GAIN; METABOLIC SYNDROME; OXIDATIVE
   STRESS; RAT; ANTIPSYCHOTICS; SCHIZOPHRENIA; PATHOGENESIS; EFFICACY;
   PROTEIN
AB Detrimental dietary habits with high-fat food are common in the psychiatric population, leading to higher obesity rate. Olanzapine (OLZ), as one of the mainstream antipsychotic drugs, shows superior efficacy in treating schizophrenia but limited by adverse effects such as obesity, dyslipidemia and liver injury, which are risk factors for the development of nonalcoholic fatty liver disease (NAFLD). Progesterone receptor component 1 (PGRMC1) is a key regulator associated with antipsychotic drug-induced metabolic disorders. Our study aims to investigate whether high-fat supplementation worsens OLZ-induced NAFLD and to validate the potential role of PGRMC1 pathway. In vivo, eight-week OLZ treatment successfully induced hepatic steatosis in female C57BL/6 mice fed with either a high-fat or normal diet, which is independent of body weight gain. Likewise, in vitro, OLZ markedly led to hepatocyte steatosis along with enhanced oxidative stress, which was aggravated by free fatty acids. Moreover, in vivo and in vitro, high-fat supplementation aggravated OLZ-induced hepatic lipid accumulation and oxidative stress via inhibition of hepatic PGRMC1-AMPK-mTORC1/Nrf2 pathways. Inspiringly, PGRMC1 over -expression effectively reversed OLZ-induced hepatocyte steatosis in vitro. Hence, hepatic PGRMC1 is attributable to OLZ-induced NAFLD especially with high-fat supplementation and potentially serves as a novel therapeutic target.
C1 [Zhu, ZhenYu; Cao, Ting; Chen, Hui; Zhang, BiKui; Lin, ChenQuan; Cai, HuaLin] Cent South Univ, Xiangya Hosp 2, Dept Pharm, Changsha, Hunan, Peoples R China.
   [Cao, Ting; Chen, Hui; Zhang, BiKui] Cent South Univ, Xiangya Sch Pharmaceut Sci, Changsha, Hunan, Peoples R China.
   [Zhu, ZhenYu; Cao, Ting; Chen, Hui; Zhang, BiKui; Lin, ChenQuan; Cai, HuaLin] Cent South Univ, Xiangya Hosp 2, Inst Clin Pharm, Changsha, Hunan, Peoples R China.
   [Zhu, ZhenYu; Cao, Ting; Chen, Hui; Zhang, BiKui; Lin, ChenQuan; Cai, HuaLin] Int Res Ctr Precis Med, Transformat Technol & Software Serv, Changsha, Hunan, Peoples R China.
C3 Central South University; Central South University; Central South
   University
RP Zhang, BK; Cai, HL (corresponding author), Cent South Univ, Xiangya Hosp 2, Dept Pharm, Changsha, Hunan, Peoples R China.
EM 505995@csu.edu.cn; hualincai@csu.edu.cn
FU Hunan Provincial Natural Science Foundation of China [2021JJ30922];
   Hunan Provincial Health Commission Research Project [202113010595];
   Changsha Municipal Natural Science Foundation [kq2007045]; New Clinical
   Medical Technology Project of the Second Xiangya Hospital of Central
   South University [CPA-Z05-ZC-2021-003]; Chinese Pharmaceutical
   Association Hospital Pharmacy Department;  [[2021] 94]
FX This work was supported in part by the grants from Hunan Provincial
   Natural Science Foundation of China (2021JJ30922), Hunan Provincial
   Health Commission Research Project (202113010595), Changsha Municipal
   Natural Science Foundation (kq2007045), Talent Project established by
   Chinese Pharmaceutical Association Hospital Pharmacy Department (No.
   CPA-Z05-ZC-2021-003) and New Clinical Medical Technology Project of the
   Second Xiangya Hospital of Central South University ( [2021] 94).
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NR 72
TC 7
Z9 7
U1 2
U2 12
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0278-6915
EI 1873-6351
J9 FOOD CHEM TOXICOL
JI Food Chem. Toxicol.
PD JUN
PY 2023
VL 176
AR 113757
DI 10.1016/j.fct.2023.113757
EA APR 2023
PG 14
WC Food Science & Technology; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Toxicology
GA F1NT5
UT WOS:000980090800001
PM 37019375
DA 2025-06-11
ER

PT J
AU Neuschwander-Tetri, BA
AF Neuschwander-Tetri, Brent A.
TI Fatty liver and the metabolic syndrome
SO CURRENT OPINION IN GASTROENTEROLOGY
LA English
DT Article
DE adipokines; angiotensin; endoplasmic reticulum stress; insulin
   resistance; steatohepatitis
ID II RECEPTOR ANTAGONIST; INSULIN-RESISTANCE; NONALCOHOLIC
   STEATOHEPATITIS; HEPATIC STEATOSIS; RISK-FACTORS; MITOCHONDRIAL
   DYSFUNCTION; OVERWEIGHT PATIENTS; DISEASE SEVERITY; TYPE-1 RECEPTOR;
   STATIN SAFETY
AB Purpose of review Nonalcoholic fatty liver disease and its subset nonalcoholic steatohepatitis represent the liver manifestations of insulin resistance. This review briefly summarizes advances in our understanding of the pathogenesis of nonalcoholic fatty liver disease and its prevalence, natural history and treatment.
   Recent findings The recognition of the role the renin-angiotensin system in promoting insulin resistance is worth noting because of available drugs. Endoplasmic reticulum stress has also become a recent target of investigation because endoplasmic reticulum stress is common in obesity, diabetes and various forms of liver disease including nonalcoholic fatty liver disease. Endoplasmic reticulum stress may be responsible for activation of c-Jun kinase, a process that may cause the hepatocellular injury in nonalcoholic steatohepatitis. Progress has also been made in estimating the prevalence of nonalcoholic fatty liver disease in adults and children. Patients enrolled in the Dallas Heart Study were found to have a 33% prevalence of nonalcoholic fatty liver disease and children dying of accidental deaths in San Diego were found to have a 13% prevalence of nonalcoholic fatty liver disease. Because about 10% of people with nonalcoholic fatty liver disease are at risk for progressive fibrosis, the burden of this disease is now quite substantial.
   Summary Incremental progress in understanding nonalcoholic fatty liver disease and nonalcoholic steatohepatitis promises to lead to hew therapeutic options for this common disease.
C1 St Louis Univ, Div Gastroenterol & Hepatol, Ctr Liver, St Louis, MO 63110 USA.
C3 Saint Louis University
RP Neuschwander-Tetri, BA (corresponding author), St Louis Univ, Div Gastroenterol & Hepatol, Ctr Liver, 3635 Vista Ave, St Louis, MO 63110 USA.
EM tetriba@slu.edu
RI Neuschwander-Tetri, Brent/IST-8116-2023
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NR 60
TC 87
Z9 97
U1 1
U2 15
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0267-1379
EI 1531-7056
J9 CURR OPIN GASTROEN
JI Curr. Opin. Gastroenterol.
PD MAR
PY 2007
VL 23
IS 2
BP 193
EP 198
DI 10.1097/MOG.0b013e32801421a9
PG 6
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 138QN
UT WOS:000244377400015
PM 17268250
DA 2025-06-11
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AU Ma, SR
   Xie, XW
AF Ma, Shu-Ren
   Xie, Xiong-Wei
TI NLRC5 deficiency promotes myocardial damage induced by high fat diet in
   mice through activating TLR4/NF-κB
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Article
DE Myocardial damage; NLRC5; Fibrosis; Inflammation; TLR4/NF-kappa B
ID NF-KAPPA-B; SIGNALING PATHWAYS; LIVER-TRANSPLANTATION;
   PULMONARY-FIBROSIS; OXIDATIVE STRESS; CANCER CELLS; INFLAMMATION; MAPK;
   EXPRESSION; INJURY
AB The metabolic syndrome could be induced by high fat diet, leading to cardiovascular diseases, such as myocardial damage. Inflammation response and oxidative stress have been reported to be involved in high fat-induced heart injury, and the molecular mechanism is not fully understood. The NOD-like protein family member, NLRC5, could interact with IKK alpha to inhibit IKK complex activation. In our study, high fat diet-feeding mice showed cardiac fibrosis, inflammation and oxidative stress through collagen accumulation, TLR4/NF-kappa B and MAPKs signaling pathways activation. NLRC5 knockout mice fed with high fat showed accelerated fibrosis and inflammation response by promoting alpha-SMA, Collagen I, Collagen III, TLR4/MyD88, phosphorylated IKKa, I kappa B alpha and NF-kappa B expression. And no effect on oxidative stress was observed in wild type and NLRC5-deficiency samples in in vivo studies. Moreover, NLRC5 knockout and - knockdown cardiac muscle cells challenged with LPS also exhibited aggravated fibrosis levels and inflammatory response without any influences on ROS production in in vitro studies. In conclusion, the findings indicated that NLRC5 showed important effects on high fat-induced heart injury via fibrosis and inflammation modulation, providing an essential target for improving myocardial damage induced by high fat diet. (C) 2017 Published by Elsevier Masson SAS.
C1 [Ma, Shu-Ren; Xie, Xiong-Wei] Nanjing Med Univ, Huaian Affiliated Hosp 1, Dept Cardiol, Huaian 223300, Peoples R China.
C3 Nanjing Medical University
RP Xie, XW (corresponding author), Nanjing Med Univ, Huaian Affiliated Hosp 1, Dept Cardiol, Huaian 223300, Peoples R China.
EM xiexiongweiha@qq.com
RI XIE, XIONGWEI/B-6691-2018
CR [Anonymous], J PHYSL BIOCH
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NR 48
TC 41
Z9 43
U1 2
U2 25
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI PARIS
PA 23 RUE LINOIS, 75724 PARIS, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD JUL
PY 2017
VL 91
BP 755
EP 766
DI 10.1016/j.biopha.2017.03.062
PG 12
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA FB8PB
UT WOS:000406399900084
PM 28499247
DA 2025-06-11
ER

PT J
AU Lefranc, C
   Friederich-Persson, M
   Palacios-Ramirez, R
   Cat, AND
AF Lefranc, Clara
   Friederich-Persson, Malou
   Palacios-Ramirez, Roberto
   Cat, Aurelie Nguyen Dinh
TI Mitochondrial oxidative stress in obesity: role of the mineralocorticoid
   receptor
SO JOURNAL OF ENDOCRINOLOGY
LA English
DT Review
DE mineralocorticoid receptor; adipose tissue; mitochondrial dysfunction;
   oxidative stress; obesity
ID WHITE ADIPOSE-TISSUE; ACTIVATED PROTEIN-KINASE; RENIN-ANGIOTENSIN
   SYSTEM; HIGH-FAT-DIET; ALDOSTERONE BINDING-SITES; INSULIN-RESISTANCE;
   METABOLIC SYNDROME; ADIPOCYTE DYSFUNCTION; POSTMENOPAUSAL WOMEN; AMPK
   ACTIVATION
AB Obesity is a multifaceted, chronic, low-grade inflammation disease characterized by excess accumulation of dysfunctional adipose tissue. It is often associated with the development of cardiovascular (CV) disorders, insulin resistance and diabetes. Under pathological conditions like in obesity, adipose tissue secretes bioactive molecules called 'adipokines', including cytokines, hormones and reactive oxygen species (ROS). There is evidence suggesting that oxidative stress, in particular, the ROS imbalance in adipose tissue, may be the mechanistic link between obesity and its associated CV and metabolic complications. Mitochondria in adipose tissue are an important source of ROS and their dysfunction contributes to the pathogenesis of obesity-related type 2 diabetes. Mitochondrial function is regulated by several factors in order to preserve mitochondria integrity and dynamics. Moreover, the renin-angiotensin-aldosterone system is over-activated in obesity. In this review, we focus on the pathophysiological role of the mineralocorticoid receptor in the adipose tissue and its contribution to obesity-associated metabolic and CV complications. More specifically, we discuss whether dysregulation of the mineralocorticoid system within the adipose tissue may be the upstream mechanism and one of the early events in the development of obesity, via induction of oxidative stress and mitochondrial dysfunction, thus impacting on systemic metabolism and the CV system.
C1 [Lefranc, Clara; Palacios-Ramirez, Roberto; Cat, Aurelie Nguyen Dinh] Paris Descartes Univ, Pierre & Marie Curie Univ, INSERM, Ctr Rech Cordeliers,UMRS 1138, Paris, France.
   [Friederich-Persson, Malou] Uppsala Univ, Med Cell Biol, Uppsala, Sweden.
C3 Institut National de la Sante et de la Recherche Medicale (Inserm);
   Universite Paris Cite; Sorbonne Universite; Uppsala University
RP Cat, AND (corresponding author), Paris Descartes Univ, Pierre & Marie Curie Univ, INSERM, Ctr Rech Cordeliers,UMRS 1138, Paris, France.
EM cattuong.ndc@gmail.com
RI CAT, Aurelie/H-8182-2013; Palacios-Ramirez, Roberto/H-9905-2015
OI Lefranc, Clara/0000-0003-4635-136X; Palacios-Ramirez,
   Roberto/0000-0002-0867-1277
FU CARMMA Avenir investment program [ANR-15-RHUS-0003]; Fondation de France
   [2014-00047968]; European COST-ADMIRE [1301]; Wenner-Gren Foundations;
   Magnus Bergvall Foundation; Ake Wiberg Foundation
FX This work was made possible with funding from CARMMA Avenir investment
   program (ANR-15-RHUS-0003), the Fondation de France (2014-00047968), and
   the European COST-ADMIRE 1301 network. M F P is supported by funding
   from the Wenner-Gren Foundations, the Magnus Bergvall Foundation and the
   Ake Wiberg Foundation.
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NR 184
TC 58
Z9 61
U1 0
U2 17
PU BIOSCIENTIFICA LTD
PI BRISTOL
PA STARLING HOUSE, 1600 BRISTOL PARKWAY N, BRISTOL, ENGLAND
SN 0022-0795
EI 1479-6805
J9 J ENDOCRINOL
JI J. Endocrinol.
PD SEP
PY 2018
VL 238
IS 3
BP R143
EP R159
DI 10.1530/JOE-18-0163
PG 17
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA HB4RJ
UT WOS:000451042500003
PM 29875164
OA Green Submitted, Bronze
DA 2025-06-11
ER

PT J
AU Cordero-Herrera, I
   Martín, MA
   Goya, L
   Ramos, S
AF Cordero-Herrera, Isabel
   Angeles Martin, Maria
   Goya, Luis
   Ramos, Sonia
TI Cocoa flavonoids protect hepatic cells against high-glucose-induced
   oxidative stress: Relevance of MAPKs
SO MOLECULAR NUTRITION & FOOD RESEARCH
LA English
DT Article
DE Antioxidant defences; Cocoa flavanols; HepG2 cells; Insulin resistance;
   Oxidative markers
ID INSULIN SIGNALING BLOCKADE; HUMAN HEPG2 CELLS; NF-KAPPA-B; KINASE-B;
   MOLECULAR-MECHANISMS; NRF2 TRANSLOCATION; METABOLIC SYNDROME; HEME
   OXYGENASE-1; GLUTATHIONE; PATHWAYS
AB Scope: Oxidative stress plays a main role in the pathogenesis of type 2 diabetes mellitus. Cocoa and (-)-epicatechin (EC), a main cocoa flavanol, have been suggested to exert beneficial effects in type 2 diabetes mellitus because of their protective effects against oxidative stress and insulin-like properties. In this study, the protective effect of EC and a cocoa phenolic extract (CPE) against oxidative stress induced by a high-glucose challenge, which causes insulin resistance, was investigated on hepatic HepG2 cells.
   Methods and results: Oxidative status, phosphorylated mitogen-activated protein kinases (MAPKs), nuclear factor E2 related factor 2 (Nrf2) and p-(Ser)-IRS-1 expression, and glucose uptake were evaluated. EC and CPE regulated antioxidant enzymes and activated extracellular-regulated kinase and Nrf2. EC and CPE pre-treatment prevented high-glucose-induced antioxidant defences and p-MAPKs, and maintained Nrf2 stimulation. The presence of selective MAPK inhibitors induced changes in redox status, glucose uptake, p-(Ser)- and total IRS-1 levels that were observed in CPE-mediated protection.
   Conclusion: EC and CPE recovered redox status of insulin-resistant HepG2 cells, suggesting that the functionality in EC-and CPE-treated cells was protected against high-glucose-induced oxidative insult. CPE beneficial effects on redox balance and insulin resistance were mediated by targeting MAPKs.
C1 [Cordero-Herrera, Isabel; Angeles Martin, Maria; Goya, Luis; Ramos, Sonia] CSIC, Dept Metab & Nutr, Inst Food Sci & Technol & Nutr ICTAN, Madrid 28040, Spain.
   [Angeles Martin, Maria] ISCIII, Ctr Invest Biomed Red Diabet & Enfermedades Metab, Madrid, Spain.
C3 Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Instituto
   de Ciencia y Tecnologia de Alimentos y Nutricion (ICTAN); Instituto de
   Salud Carlos III; CIBER - Centro de Investigacion Biomedica en Red;
   CIBERDEM
RP Ramos, S (corresponding author), CSIC, Dept Metab & Nutr, Inst Food Sci & Technol & Nutr ICTAN, Ciudad Univ,Jose Antonio Novais 10, Madrid 28040, Spain.
EM s.ramos@ictan.csic.es
RI Santos, M.A./L-9005-2014; Goya, Luis/H-5735-2012; Martin, Maria
   Angeles/C-5768-2014; Ramos, Sonia/K-4594-2012
OI Goya, Luis/0000-0001-9449-6200; Martin, Maria
   Angeles/0000-0001-8173-4521; Ramos, Sonia/0000-0003-2649-2616
FU Spanish Ministry of Science and Innovation (MICINN) [AGL2010-17579,
   CSD2007-00063]
FX This work was supported by the grants AGL2010-17579 and CSD2007-00063
   from the Spanish Ministry of Science and Innovation (MICINN). I.
   Cordero-Herrera is a fellow of the FPI pre-doctoral program of MICINN.
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NR 56
TC 85
Z9 90
U1 0
U2 68
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1613-4125
EI 1613-4133
J9 MOL NUTR FOOD RES
JI Mol. Nutr. Food Res.
PD APR
PY 2015
VL 59
IS 4
BP 597
EP 609
DI 10.1002/mnfr.201400492
PG 13
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA CF8CK
UT WOS:000352782800001
PM 25594685
DA 2025-06-11
ER

PT J
AU Dahan, T
   Nassar, S
   Yajuk, O
   Steinberg, E
   Benny, O
   Abudi, N
   Plaschkes, I
   Benyamini, H
   Gozal, D
   Abramovitch, R
   Gileles-Hillel, A
AF Dahan, Tehila
   Nassar, Shahd
   Yajuk, Olga
   Steinberg, Eliana
   Benny, Ofra
   Abudi, Nathalie
   Plaschkes, Inbar
   Benyamini, Hadar
   Gozal, David
   Abramovitch, Rinat
   Gileles-Hillel, Alex
TI Chronic Intermittent Hypoxia during Sleep Causes Browning of
   Interscapular Adipose Tissue Accompanied by Local Insulin Resistance in
   Mice
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE hypoxia; sleep apnea; intermittent hypoxia; glucose tolerance; insulin
   sensitivity; brown adipose tissue; metabolism
ID MURINE MODEL; INFLAMMATION; OBESITY; APNEA; DYSFUNCTION; FAT;
   ANGIOGENESIS; OXYGENATION; RAREFACTION; ACTIVATION
AB Obstructive sleep apnea (OSA) is a highly prevalent condition, characterized by intermittent hypoxia (IH), sleep disruption, and altered autonomic nervous system function. OSA has been independently associated with dyslipidemia, insulin resistance, and metabolic syndrome. Brown adipose tissue (BAT) has been suggested as a modulator of systemic glucose tolerance through adaptive thermogenesis. Reductions in BAT mass have been associated with obesity and metabolic syndrome. No studies have systematically characterized the effects of chronic IH on BAT. Thus, we aimed to delineate IH effects on BAT and concomitant metabolic changes. C57BL/6J 8-week-old male mice were randomly assigned to IH during sleep (alternating 90 s cycles of 6.5% FIO2 followed by 21% FIO2) or normoxia (room air, RA) for 10 weeks. Mice were subjected to glucose tolerance testing and F-18-FDG PET-MRI towards the end of the exposures followed by BAT tissues analyses for morphological and global transcriptomic changes. Animals exposed to IH were glucose intolerant despite lower total body weight and adiposity. BAT tissues in IH-exposed mice demonstrated characteristic changes associated with "browning"-smaller lipids, increased vascularity, and a trend towards higher protein levels of UCP1. Conversely, mitochondrial DNA content and protein levels of respiratory chain complex III were reduced. Pro-inflammatory macrophages were more abundant in IH-exposed BAT. Transcriptomic analysis revealed increases in fatty acid oxidation and oxidative stress pathways in IH-exposed BAT, along with a reduction in pathways related to myogenesis, hypoxia, and IL-4 anti-inflammatory response. Functionally, IH-exposed BAT demonstrated reduced absorption of glucose on PET scans and reduced phosphorylation of AKT in response to insulin. Current studies provide initial evidence for the presence of a maladaptive response of interscapular BAT in response to chronic IH mimicking OSA, resulting in a paradoxical divergence, namely, BAT browning but tissue-specific and systemic insulin resistance. We postulate that oxidative stress, mitochondrial dysfunction, and inflammation may underlie these dichotomous outcomes in BAT.
C1 [Dahan, Tehila; Nassar, Shahd; Abudi, Nathalie; Abramovitch, Rinat; Gileles-Hillel, Alex] Hadassah Med Ctr, Wohl Inst Translat Med, IL-91120 Jerusalem, Israel.
   [Nassar, Shahd; Yajuk, Olga; Abramovitch, Rinat; Gileles-Hillel, Alex] Hebrew Univ Jerusalem, Fac Med, IL-91904 Jerusalem, Israel.
   [Steinberg, Eliana; Benny, Ofra] Hebrew Univ Jerusalem, Inst Drug Res, Fac Med, Sch Pharm, IL-91904 Jerusalem, Israel.
   [Plaschkes, Inbar; Benyamini, Hadar] Hebrew Univ Jerusalem, Bioinformat Unit I CORE, Info CORE, IL-91904 Jerusalem, Israel.
   [Gozal, David] Univ Missouri, MU Childrens Hosp, Comprehens Sleep Med Ctr, Sch Med,Dept Child Hlth,Div Pediat Pulmonol Allerg, Columbia, MO 65201 USA.
   [Gileles-Hillel, Alex] Hadassah Med Ctr, Dept Pediat, Pediat Pulmonol & Sleep Unit, IL-91120 Jerusalem, Israel.
C3 Hebrew University of Jerusalem; Hadassah University Hospital; Hadassah
   University Medical Center; Hebrew University of Jerusalem; Hebrew
   University of Jerusalem; Hebrew University of Jerusalem; University of
   Missouri System; University of Missouri Columbia; Hebrew University of
   Jerusalem; Hadassah University Medical Center; Hadassah University
   Hospital
RP Gileles-Hillel, A (corresponding author), Hadassah Med Ctr, Wohl Inst Translat Med, IL-91120 Jerusalem, Israel.; Gileles-Hillel, A (corresponding author), Hebrew Univ Jerusalem, Fac Med, IL-91904 Jerusalem, Israel.; Gileles-Hillel, A (corresponding author), Hadassah Med Ctr, Dept Pediat, Pediat Pulmonol & Sleep Unit, IL-91120 Jerusalem, Israel.
EM alex.gileles@mail.huji.ac.il
RI Benny, Ofra/AAB-3294-2021; Gozal, David/ABH-3805-2020; Gileles-Hillel,
   Alexander/K-6674-2019
OI Gileles-Hillel, Alex/0000-0002-0656-905X; Gozal,
   David/0000-0001-8195-6036
FU Israel Science Foundation; American Thoracic Society [AG061824];
   Hadassah Medical Center Bridging Grant; NIH; University of Missouri
   [2779/19]
FX This work was supported by grant 2779/19 from the Israel Science
   Foundation, a research grant from the American Thoracic Society, and the
   Hadassah Medical Center Bridging Grant. DG is supported in part by NIH
   grant AG061824 and by Tier 2 and TRIUMPH grants from the University of
   Missouri.
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NR 75
TC 13
Z9 13
U1 0
U2 7
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD DEC
PY 2022
VL 23
IS 24
AR 15462
DI 10.3390/ijms232415462
PG 16
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 7G3ON
UT WOS:000902438300001
PM 36555109
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Planchart, A
   Green, A
   Hoyo, C
   Mattingly, CJ
AF Planchart, Antonio
   Green, Adrian
   Hoyo, Cathrine
   Mattingly, Carolyn J.
TI Heavy Metal Exposure and Metabolic Syndrome: Evidence from Human and
   Model System Studies
SO CURRENT ENVIRONMENTAL HEALTH REPORTS
LA English
DT Article
DE Metabolic syndrome; Diabetes; Heavy metals; Cadmium; Pb; Mercury
ID KOREA NATIONAL-HEALTH; HIGH-FAT DIET; CADMIUM EXPOSURE; BLOOD MERCURY;
   ENVIRONMENTAL CHEMICALS; INSULIN-RESISTANCE; OXIDATIVE STRESS; URINARY
   CADMIUM; TRACE-ELEMENTS; FETAL-GROWTH
AB Purpose of ReviewMetabolic syndrome (MS) describes the co-occurrence of conditions that increase one's risk for heart disease and other disorders such as diabetes and stroke. The worldwide increase in the prevalence of MS cannot be fully explained by lifestyle factors such as sedentary behavior and caloric intake alone. Environmental exposures, such as heavy metals, have been implicated, but results are conflicting and possible mechanisms remain unclear. To assess recent progress in determining a possible role between heavy metal exposure and MS, we reviewed epidemiological and model system data for cadmium (Cd), lead (Pb), and mercury (Hg) from the last decade.Recent FindingsData from 36 epidemiological studies involving 17 unique countries/regions and 13 studies leveraging model systems are included in this review. Epidemiological and model system studies support a possible association between heavy metal exposure and MS or comorbid conditions; however, results remain conflicting. Epidemiological studies were predominantly cross-sectional and collectively, they highlight a global interest in this question and reveal evidence of differential susceptibility by sex and age to heavy metal exposures. In vivo studies in rats and mice and in vitro cell-based assays provide insights into potential mechanisms of action relevant to MS including altered regulation of lipid and glucose homeostasis, adipogenesis, and oxidative stress.SummaryHeavy metal exposure may contribute to MS or comorbid conditions; however, available data are conflicting. Causal inference remains challenging as epidemiological data are largely cross-sectional; and variation in study design, including samples used for heavy metal measurements, age of subjects at which MS outcomes are measured; the scope and treatment of confounding factors; and the population demographics vary widely. Prospective studies, standardization or increased consistency across study designs and reporting, and consideration of molecular mechanisms informed by model system studies are needed to better assess potential causal links between heavy metal exposure and MS.
C1 [Planchart, Antonio; Green, Adrian; Hoyo, Cathrine; Mattingly, Carolyn J.] NC State Univ, Dept Biol Sci, Toxicol Bldg,850 Main Campus Dr, Raleigh, NC 27606 USA.
   [Planchart, Antonio; Hoyo, Cathrine; Mattingly, Carolyn J.] NC State Univ, Ctr Human Hlth & Environm, Toxicol Bldg,850 Main Campus Dr, Raleigh, NC 27606 USA.
C3 North Carolina State University; North Carolina State University
RP Mattingly, CJ (corresponding author), NC State Univ, Dept Biol Sci, Toxicol Bldg,850 Main Campus Dr, Raleigh, NC 27606 USA.; Mattingly, CJ (corresponding author), NC State Univ, Ctr Human Hlth & Environm, Toxicol Bldg,850 Main Campus Dr, Raleigh, NC 27606 USA.
EM ajplanch@ncsu.edu; ajgreen4@ncsu.edu; choyo@ncsu.edu; cjmattin@ncsu.edu
RI Green, Adrian/HNC-5214-2023
OI Mattingly, Carolyn/0000-0002-2146-9436; Planchart,
   Antonio/0000-0001-8691-8856; Green, Adrian/0000-0001-9429-1838; Hoyo,
   Cathrine/0000-0002-2466-8617
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NR 70
TC 121
Z9 130
U1 8
U2 51
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
EI 2196-5412
J9 CURR ENV HLTH REP
JI Curr. Environ. Health Rep.
PD MAR
PY 2018
VL 5
IS 1
BP 110
EP 124
DI 10.1007/s40572-018-0182-3
PG 15
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA VJ1SI
UT WOS:000544898600010
PM 29460222
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Panov, AV
   Dikalov, SI
AF Panov, Alexander V.
   Dikalov, Sergey I.
TI Cardiolipin, Perhydroxyl Radicals, and Lipid Peroxidation in
   Mitochondrial Dysfunctions and Aging
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Review
ID OXYGEN SPECIES GENERATION; FATTY-ACID OXIDATION; IN-VIVO; PERMEABILITY
   TRANSITION; HEART MITOCHONDRIA; METABOLIC SYNDROME; HYDROGEN-PEROXIDE;
   RESPIRATORY-CHAIN; MTDNA MUTATIONS; PROTON-TRANSFER
AB Mitochondrial dysfunctions caused by oxidative stress are currently regarded as the main cause of aging. Accumulation of mutations and deletions of mtDNA is a hallmark of aging. So far, however, there is no evidence that most studied oxygen radicals are directly responsible for mutations of mtDNA. Oxidative damages to cardiolipin (CL) and phosphatidylethanolamine (PEA) are also hallmarks of oxidative stress, but the mechanisms of their damage remain obscure. CL is the only phospholipid present almost exclusively in the inner mitochondrial membrane (IMM) where it is responsible, together with PEA, for the maintenance of the superstructures of oxidative phosphorylation enzymes. CL has negative charges at the headgroups and due to specific localization at the negative curves of the IMM, it creates areas with the strong negative charge where local pH may be several units lower than in the surrounding bulk phases. At these sites with the higher acidity, the chance of protonation of the superoxide radical (O-2(center dot)), generated by the respiratory chain, is much higher with the formation of the highly reactive hydrophobic perhydroxyl radical (HO2 center dot). HO(2)(center dot)specifically reacts with the double bonds of polyunsaturated fatty acids (PUFA) initiating the isoprostane pathway of lipid peroxidation. Because HO(2)(center dot)is formed close to CL aggregates and PEA, it causes peroxidation of the linoleic acid in CL and also damages PEA. This causes disruption of the structural and functional integrity of the respirosomes and ATP synthase. We provide evidence that in elderly individuals with metabolic syndrome (MetS), fatty acids become the major substrates for production of ATP and this may increase several-fold generation of O(2)(center dot)and thus HO2 center dot. We conclude that MetS accelerates aging and the mitochondrial dysfunctions are caused by the HO2 center dot-induced direct oxidation of CL and the isoprostane pathway of lipid peroxidation (IPLP). The toxic products of IPLP damage not only PEA, but also mtDNA and OXPHOS proteins. This results in gradual disruption of the structural and functional integrity of mitochondria and cells.
C1 [Panov, Alexander V.] Fed Sci Ctr Family Hlth & Human Reprod Problems, 16 Timiryasev Str, Irkutsk 664003, Russia.
   [Dikalov, Sergey I.] Vanderbilt Univ, Med Ctr, Div Clin Pharmacol, Nashville, TN 37232 USA.
C3 Vanderbilt University
RP Panov, AV (corresponding author), Fed Sci Ctr Family Hlth & Human Reprod Problems, 16 Timiryasev Str, Irkutsk 664003, Russia.
EM alexander.panov55@gmail.com; sergey.dikalov@vanderbilt.edu
RI Dikalov, Sergey/C-6600-2016; Panov, Alexander/K-7590-2017
OI Dikalov, Sergey/0000-0003-2976-6184; Panov,
   Alexander/0000-0001-8198-7780
FU National Institutes of Health [R01HL124116, R01HL144943]
FX This work was supported by R01HL124116 and R01HL144943 National
   Institutes of Health grants.
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NR 111
TC 54
Z9 62
U1 1
U2 19
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PD SEP 9
PY 2020
VL 2020
AR 1323028
DI 10.1155/2020/1323028
PG 14
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA NV4QB
UT WOS:000574307200002
PM 32963690
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Nakatsuji, H
   Kishida, K
   Kitamura, T
   Nakajima, C
   Funahashi, T
   Shimomura, I
AF Nakatsuji, Hideaki
   Kishida, Ken
   Kitamura, Teruo
   Nakajima, Chika
   Funahashi, Tohru
   Shimomura, Iichiro
TI Dysregulation of glucose, insulin, triglyceride, blood pressure, and
   oxidative stress after an oral glucose tolerance test in men with
   abdominal obesity
SO METABOLISM-CLINICAL AND EXPERIMENTAL
LA English
DT Article
ID ENDOTHELIAL FUNCTION; POSTPRANDIAL HYPERGLYCEMIA; NONFASTING
   TRIGLYCERIDES; CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME;
   HEART-DISEASE; RISK-FACTOR; ADIPONECTIN; EXPRESSION; DIAGNOSIS
AB Postprandial metabolic dysregulation plays a role in the development of atherosclerosis. Visceral fat accumulation is an important component of various metabolic disorders including glucose intolerance, dyslipidemia, and hypertension, which correlate with atherosclerotic cardiovascular disease. The aim of the present study was to compare the postprandial response of various metabolic parameters, blood pressure, adiponectin, and oxidative stress to 75-g oral glucose tolerance test (OGTT) in men with (n = 23) and without (n = 7) abdominal obesity based on waist circumference (WC) cutoff value of 85 cm (based on the Japanese criteria for the metabolic syndrome). The cross-sectional prospective study included 30 male subjects who were on no medications and newly diagnosed with mild hypertension and/or dyslipidemia. The percentage change in each parameter ([each parameter at 120 minutes after an OGTT that before an OGTT]/that before an OGTT x 100) was calculated. The percentage systolic blood pressure, percentage diastolic blood pressure, and percentage triglyceride were -6.3% +/- 3.5%, -9.4% +/- 3.0%, and -10.2% +/- 2.1%, respectively, in the WC less than 85 group (vs baseline: P = .10, P < .01, and P < .001) and 2.0% +/- 1.7%, 0.9% +/- 2.4%, and 2.8% +/- 3.3%, respectively, in the WC at least 85 group (vs WC <85 group: P <.05, each). However, there were no significant differences in percentage total cholesterol and percentage high-density lipoprotein cholesterol between the 2 groups. The percentage thiobarbituric acid reacting substances tended to be lower in the WC less than 85 group (vs baseline: P = .07), but not in the WC at least 85 group, albeit statistically insignificant (WC <85 vs >= 85 group: P = .057). The maximum carotid intima-media thickness was larger in the WC at least 85 group than the WC less than 85 group (P < .05). Evaluation of postprandial changes in obesity-related parameters may be important in preventing atherosclerotic diseases. (C) 2010 Elsevier Inc. All rights reserved.
C1 [Nakatsuji, Hideaki; Kishida, Ken; Nakajima, Chika; Funahashi, Tohru; Shimomura, Iichiro] Osaka Univ, Grad Sch Med, Dept Metab Med, Suita, Osaka 5650871, Japan.
   [Kitamura, Teruo] Kitamura Clin, Amagasaki, Hyogo, Japan.
C3 The University of Osaka
RP Kishida, K (corresponding author), Osaka Univ, Grad Sch Med, Dept Metab Med, Suita, Osaka 5650871, Japan.
EM kkishida@imed2.mcd.osaka-u.ac.jp
FU Ministry of Health, Labor, and Welfare [21591177, KH21AI005a]; Takeda
   Medical Research Foundation; Grants-in-Aid for Scientific Research
   [21591177] Funding Source: KAKEN
FX This work was supported in part by a Grants-in-Aid for Scientific
   Research No. (C) 21591177 (to KK); a Research Grant (No. KH21AI005a)
   from the Ministry of Health, Labor, and Welfare (to TF); Takeda Medical
   Research Foundation (to TF).
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NR 41
TC 20
Z9 26
U1 0
U2 3
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0026-0495
EI 1532-8600
J9 METABOLISM
JI Metab.-Clin. Exp.
PD APR
PY 2010
VL 59
IS 4
BP 520
EP 526
DI 10.1016/j.metabol.2009.08.013
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 576ZO
UT WOS:000276189200010
PM 19850310
DA 2025-06-11
ER

PT J
AU Iizuka, Y
   Kim, H
   Izawa, T
   Sakurai, K
   Hirako, S
   Wada, M
   Matsumoto, A
AF Iizuka, Yuzuru
   Kim, Hyounju
   Izawa, Takuya
   Sakurai, Koji
   Hirako, Satoshi
   Wada, Masahiro
   Matsumoto, Akiyo
TI Protective effects of fish oil and pioglitazone on pancreatic tissue in
   obese KK mice with type 2 diabetes
SO PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
LA English
DT Article
DE Fish oil; Pioglitazone; Protective effect; Islet hypertrophy; beta-cell
   dysfunction
ID ACTIVATED RECEPTOR-GAMMA; STIMULATED INSULIN-SECRETION;
   ENDOPLASMIC-RETICULUM STRESS; BETA-CELL MASS; METABOLIC SYNDROME;
   OXIDATIVE STRESS; DB/DB MICE; ISLETS; ADIPONECTIN; MECHANISMS
AB n-3 Polyunsaturated fatty acids, such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), have protective effects against the pancreatic beta-cell dysfunction through several mechanisms. Thiazolidines are insulin sensitizers and are used in treating patients with type 2 diabetes. Our previous study demonstrated that a combination of fish oil, which is rich with EPA and DHA, and pioglitazone exerts beneficial effects on obesity and diabetes through their actions on the liver and adipose tissue. However, it remains largely unknown whether such combination therapy affects the pancreas. To answer this question, KK mice, which serve as a model for obesity and type 2 diabetes, were treated for 8 weeks with fish oil and pioglitazone. The combined regimen suppressed pancreatic islet hypertrophy (mean islet area decreased by an average of 49% vs. control) compared with mice treated with fish oil or pioglitazone alone (decreased by an average of 21% and 32% vs. control, respectively). Compared with the controls, individual or combined treatment significantly increased the percentage of beta-cell area in the pancreatic islets, significantly decreased endoplasmic reticulum stress, and reduced the percentage of apoptotic cell death in the pancreatic islets. These findings suggest that fish oil and/or pioglitazone prevents beta-cell dysfunction by improving the insulin resistance and decreasing the ER stress.
C1 [Iizuka, Yuzuru; Kim, Hyounju; Izawa, Takuya; Sakurai, Koji; Wada, Masahiro; Matsumoto, Akiyo] Josai Univ, Fac Pharmaceut Sci, Dept Clin Dietet & Human Nutr, Saitama, Japan.
   [Hirako, Satoshi] Univ Human Arts & Sci, Dept Hlth & Nutr, Saitama, Japan.
C3 Josai University
RP Kim, H (corresponding author), Josai Univ, Fac Pharmaceut Sci, Dept Clin Dietet & Human Nutr, Saitama, Japan.
EM hyounju@josai.ac.jp
FU JSPS KAKENHI [25504012]; Grants-in-Aid for Scientific Research
   [25504012] Funding Source: KAKEN
FX We would like to thank NOF Corporation (Tokyo, Japan) for providing fish
   oil. This research was supported by JSPS KAKENHI Grant no. 25504012.
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NR 38
TC 13
Z9 15
U1 0
U2 12
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0952-3278
EI 1532-2823
J9 PROSTAG LEUKOTR ESS
JI Prostaglandins Leukot. Essent. Fatty Acids
PD DEC
PY 2016
VL 115
BP 53
EP 59
DI 10.1016/j.plefa.2016.10.007
PG 7
WC Biochemistry & Molecular Biology; Cell Biology; Endocrinology &
   Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology; Endocrinology &
   Metabolism
GA EG0MW
UT WOS:000390727900008
PM 27914514
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Tian, JL
   Zhang, Y
   Chen, BY
AF Tian Jian-li
   Zhang Yun
   Chen Bao-yuan
TI Sleep apnea hypopnea syndrome and liver injuiry
SO CHINESE MEDICAL JOURNAL
LA English
DT Review
DE sleep apnea hypopnea syndrome; intermittent hypoxia; nonalcoholic fatty
   liver disease; insulin resistance; oxidative stress
ID CHRONIC INTERMITTENT HYPOXIA; NONALCOHOLIC FATTY LIVER; SERUM
   AMINOTRANSFERASE LEVELS; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   OXIDATIVE STRESS; OBESE-PATIENTS; CARDIOVASCULAR-DISEASE;
   LIPID-PEROXIDATION; HEPATIC STEATOSIS
AB Objective A general review was made of studies involving: (1) the relationship between sleep apnea hypopnea syndrome/sleep apnea style intermittent hypoxia and liver injury and (2) the mechanism that causes the liver injury. Data sources The data used in this review were mainly from Medline and PubMed published in English from 1993 to February 2009. The search term was "sleep apnea hypopnea syndrome".
   Study selection (1) Clinical and laboratory evidence that sleep apnea hypopnea syndrome and sleep apnea style intermittent hypoxia leads to liver injury; (2) the mechanism that causes the liver injury.
   Results The effect of sleep apnea hypopnea syndrome and sleep apnea style intermittent hypoxia on the liver function is characterized by serum aminotransferase elevation. The liver histological injury includes hepatic steatosis, hepatocyte ballooning, lobular inflammation, lobular necrosis, and liver fibrosis. Sleep apnea hypopnea syndrome and sleep apnea style intermittent hypoxia can cause insulin resistance and oxidative stress.
   Conclusions Sleep apnea hypopnea syndrome and sleep apnea style intermittent hypoxia can lead to chronic liver injury, which, in most cases, is shown as nonalcoholic fatty liver disease. Insulin resistance and oxidative stress caused by sleep apnea hypopnea syndrome and sleep apnea style intermittent hypoxia play an important role in the mechanism of chronic liver disease development. Chin Med J 2010;123(1):89-94
C1 [Tian Jian-li; Zhang Yun] Tianjin Med Univ, Gen Hosp, Dept Gerontol, Tianjin 300052, Peoples R China.
   [Chen Bao-yuan] Tianjin Med Univ, Gen Hosp, Dept Resp Med, Tianjin 300052, Peoples R China.
C3 Tianjin Medical University; Tianjin Medical University
RP Tian, JL (corresponding author), Tianjin Med Univ, Gen Hosp, Dept Gerontol, Tianjin 300052, Peoples R China.
EM tjltianjianli@hotmail.com
RI Chen, Luzeng/AAW-4390-2021
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NR 44
TC 11
Z9 13
U1 0
U2 9
PU CHINESE MEDICAL ASSOC
PI BEIJING
PA 42 DONGSI XIDAJIE, BEIJING 100710, PEOPLES R CHINA
SN 0366-6999
J9 CHINESE MED J-PEKING
JI Chin. Med. J.
PD JAN 5
PY 2010
VL 123
IS 1
BP 89
EP 94
DI 10.3760/cma.j.issn.0366-6999.2010.01.016
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 547ON
UT WOS:000273899000017
PM 20137582
DA 2025-06-11
ER

PT J
AU Walss-Bass, C
   Weintraub, ST
   Hatch, J
   Mintz, J
   Chaudhuri, AR
AF Walss-Bass, Consuelo
   Weintraub, Susan T.
   Hatch, John
   Mintz, Jim
   Chaudhuri, Asish R.
TI Clozapine causes oxidation of proteins involved in energy metabolism: a
   possible mechanism for antipsychotic-induced metabolic alterations
SO INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
LA English
DT Article
DE Glucose metabolism; oxidative stress; proteomics; reactive oxygen
   species
ID COA TRANSFERASE SCOT; RAT-BRAIN; ATYPICAL ANTIPSYCHOTICS; SCHIZOPHRENIA;
   HALOPERIDOL; EXPRESSION; STRESS; OLANZAPINE; ENZYMES; CLONING
AB Although atypical antipsychotics are widely known to induce alterations in lipid and glucose metabolism, the mechanisms by which these alterations occur remain unknown. Several recent studies have shown that atypical antipsychotics induce oxidative stress and oxidative cell injury by increasing levels of lipid and protein oxidation. In this study, a novel proteomic approach was used to identify specific proteins oxidized after clozapine treatment. Differentiated neuroblastoma SKNSH cells were treated with 0, 5 or 20 mu M clozapine for 24 h and protein extracts were labelled with 6-iodoacetamide fluorescein (6-IAF). The lack of incorporation of 6-IAF to cysteine residues is an indicator of protein oxidation. Labelled proteins were exposed to 2D electrophoresis, and differential protein labelling was assessed. Increased oxidation after clozapine treatment was observed in 10 protein spots (p < 0.05), although only four of them remained significant after correcting for analysis with two drug concentrations. Five proteins, corresponding to nine of the spots, were identified by HPLC-electrospray ionization tandem mass spectrometry (HPLC-ESI-MS/MS) as mitochondrial ribosomal protein S22, mitochondrial malate dehydrogenase, calumenin, pyruvate kinase and 3-oxoacid CoA transferase. The latter four proteins play important roles in energy metabolism. These results suggest that oxidative stress may be a mechanism by which antipsychotics increase the risk for metabolic syndrome and diabetes.
C1 [Walss-Bass, Consuelo; Hatch, John; Mintz, Jim] Univ Texas Hlth Sci Ctr San Antonio, Dept Psychiat, San Antonio, TX 78229 USA.
   [Weintraub, Susan T.; Chaudhuri, Asish R.] Univ Texas Hlth Sci Ctr San Antonio, Dept Biochem, San Antonio, TX 78229 USA.
   [Hatch, John] Univ Texas Hlth Sci Ctr San Antonio, Dept Orthodont, San Antonio, TX 78229 USA.
C3 University of Texas System; University of Texas Health Science Center at
   San Antonio; University of Texas System; University of Texas Health
   Science Center at San Antonio; University of Texas System; University of
   Texas Health Science Center at San Antonio
RP Walss-Bass, C (corresponding author), 7703 Floyd Curl Dr, San Antonio, TX 78229 USA.
EM walss@uthscsa.edu
RI Mintz, Jim/N-7385-2014; Walss-Bass, Consuelo/K-5702-2015
OI Walss-Bass, Consuelo/0000-0003-2474-5448
FU Stanley Medical Research Institute
FX Mass spectrometry analysis was performed by the UTHSCSA Mass
   Spectrometry Core Facility. We thank Andrea Nicks and Kevin Hakala for
   their help with 2D gel electrophoresis and mass spectrometry analysis,
   respectively. This study was supported by a grant from the Stanley
   Medical Research Institute to C.W-B.
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NR 25
TC 43
Z9 46
U1 0
U2 8
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1461-1457
EI 1469-5111
J9 INT J NEUROPSYCHOPH
JI Int. J. Neuropsychopharmacol.
PD DEC
PY 2008
VL 11
IS 8
BP 1097
EP 1104
DI 10.1017/S1461145708008882
PG 8
WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA 375KH
UT WOS:000261112100007
PM 18466668
OA Bronze
DA 2025-06-11
ER

PT J
AU Kukko, V
   Kaipia, A
   Talala, K
   Taari, K
   Tammela, TLJ
   Auvinen, A
   Murtola, TJ
AF Kukko, Ville
   Kaipia, Antti
   Talala, Kirsi
   Taari, Kimmo
   Tammela, Teuvo L. J.
   Auvinen, Anssi
   Murtola, Teemu J.
TI Allopurinol and risk of benign prostatic hyperplasia in a Finnish
   population-based cohort
SO PROSTATE CANCER AND PROSTATIC DISEASES
LA English
DT Review
ID CANCER SCREENING TRIAL; OXIDATIVE STRESS; METABOLIC SYNDROME; URIC-ACID;
   OBESITY; VITAMIN; OXIDASE
AB Background Metabolic syndrome and obesity are linked with hyperuricemia, and it has also been proposed that oxidative stress associated with hyperuricemia may promote benign prostatic hyperplasia (BPH). However, it is currently unknown whether use of antihyperuricemic medication is associated with risk of developing BPH. We studied the association between BPH and use of antihyperuricemic allopurinol in a Finnish population-based cohort.
   Methods The study cohort consisted of 74,754 men originally identified for the Finnish Randomized Study of Screening for Prostate Cancer (FinRSPC). Information on gout and BPH medication usage (5 alpha-reductase inhibitors, 5ARIs) during 1996-2014 was obtained from the National medication reimbursement database. Information on BPH diagnoses from in- and outpatient hospital visits and BPH-related surgery was obtained from the National Health Care Registry. Men with a record of BPH at baseline was excluded. We used Cox regression to analyze risk of starting BPH medication, having a recorded diagnosis or undergoing BPH surgery by allopurinol use with adjustment for age and simultaneous use of statins, antidiabetic or antihypertensive drugs and aspirin or other NSAIDs. Medication use was analyzed as a time-dependent variable to minimize immortal time bias.
   Results Men using allopurinol had a decreased risk for all three BPH endpoints: BPH medication (HR 0.81; 95% CI 0.75-0.88), BPH diagnosis (HR 0.78; 95% CI 0.71-0.86) and BPH-related surgery (HR 0.67; 95% CI 0.58-0.76) after multivariable adjustment. The risk association did not change by cumulative use. The risk decrease disappeared after 1-2 years lag time. Only BMI modified the risk association; the risk decrease was observed only among men with BMI above the median (27.3 kg/m(2)); p for interaction < 0.05 for each endpoint.
   Conclusions We found that allopurinol use is associated with lowered risk of BPH medication, diagnosis and surgery. A possible explanation could be antioxidative effects of urate-lowering allopurinol.
C1 [Kukko, Ville; Tammela, Teuvo L. J.; Murtola, Teemu J.] Univ Tampere, Fac Med & Life Sci, Tampere, Finland.
   [Kaipia, Antti; Tammela, Teuvo L. J.; Murtola, Teemu J.] Tampere Univ Hosp, Dept Urol, Tampere, Finland.
   [Talala, Kirsi] Finnish Canc Registry, Helsinki, Finland.
   [Taari, Kimmo] Univ Helsinki, Dept Urol, Helsinki, Finland.
   [Taari, Kimmo] Helsinki Univ Hosp, Helsinki, Finland.
   [Auvinen, Anssi] Univ Tampere, Fac Social Sci, Tampere, Finland.
C3 Tampere University; Tampere University; Tampere University Hospital;
   Finnish Cancer Registry; University of Helsinki; University of Helsinki;
   Helsinki University Central Hospital; Tampere University
RP Kukko, V (corresponding author), Univ Tampere, Fac Med & Life Sci, Tampere, Finland.
EM kukko.ville.t@student.uta.fi
RI Auvinen, Anssi/AAD-9311-2020
OI Auvinen, Anssi/0000-0003-1125-4818; Kukko, Ville/0000-0001-9584-8693;
   Taari, Kimmo/0000-0002-0077-4896
FU Astellas; Bayer; Roche; Astellasand Janssen Cilag; GSK; Janssen Cilag;
   Abbvie; Medivation; Orion
FX T.L.J. Tammela: consultant fees from Astellas, Bayer, and Roche. T.J.
   Murtola: consultant fees from Astellasand Janssen Cilag. Lecture fees
   from Astellas, GSK, and Janssen Cilag. K Taari: Consultant fee from
   Abbvie, research funding from Medivation, travel support from Astellas,
   and Orion. Remaining authors declare no conflict of interest.
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NR 23
TC 7
Z9 7
U1 0
U2 6
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1365-7852
EI 1476-5608
J9 PROSTATE CANCER P D
JI Prostate Cancer Prostatic Dis.
PD SEP
PY 2018
VL 21
IS 3
BP 373
EP 378
DI 10.1038/s41391-017-0031-8
PG 6
WC Oncology; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Urology & Nephrology
GA GS5OM
UT WOS:000443715600008
PM 29273728
OA Green Accepted, Green Submitted
DA 2025-06-11
ER

PT J
AU Gao, MJ
   Zhao, Z
   Lv, PY
   Li, YF
   Gao, JT
   Zhang, M
   Zhao, BL
AF Gao, Mingjing
   Zhao, Zhen
   Lv, Pengyu
   Li, YuFang
   Gao, Juntao
   Zhang, Michael
   Zhao, Baolu
TI Quantitative combination of natural anti-oxidants prevents metabolic
   syndrome by reducing oxidative stress
SO REDOX BIOLOGY
LA English
DT Article
DE Insulin resistance; Abdominal obesity; Anti-oxidants; Quantitative
   combination; Hill function; High fat diet-fed rats and KK-ay mice
ID GREEN TEA; VITAMIN-C; INSULIN-RESISTANCE; FAT DIET; POLYPHENOLS;
   EXTRACTS; MODEL
AB Insulin resistance and abdominal obesity are present in the majority of people with the metabolic syndrome. Antioxidant therapy might be a useful strategy for type 2 diabetes and other insulin-resistant states. The combination of vitamin C (Vc) and vitamin E has synthetic scavenging effect on free radicals and inhibition effect on lipid peroxidation. However, there are few studies about how to define the best combination of more than three anti-oxidants as it is difficult or impossible to test the anti-oxidant effect of the combination of every concentration of each ingredient experimentally. Here we present a math model, which is based on the classical Hill equation to determine the best combination, called Fixed Dose Combination (FDC), of several natural anti-oxidants, including Vc, green tea polyphenols (GTP) and grape seed extract proanthocyanidin (GSEP). Then we investigated the effects of FDC on oxidative stress, blood glucose and serum lipid levels in cultured 3T3-L1 adipocytes, high fat diet (HFD)-fed rats which serve as obesity model, and KK-ay mice as diabetic model. The level of serum malondialdehyde (MDA) in the treated rats was studied and Hematoxylin-Eosin (HE) staining or Oil red slices of liver and adipose tissue in the rats were examined as well. FDC shows excellent antioxidant and anti-glycation activity by attenuating lipid peroxidation. FDC determined in this investigation can become a potential solution to reduce obesity, to improve insulin sensitivity and be beneficial for the treatment of fat and diabetic patients. It is the first time to use the math model to determine the best ratio of three anti-oxidants, which can save much more time and chemical materials than traditional experimental method. This quantitative method represents a potentially new and useful strategy to screen all possible combinations of many natural anti-oxidants, therefore may help develop novel therapeutics with the potential to ameliorate the worldwide metabolic abnormalities. (C) 2015 The Authors. Published by Elsevier B.V.
C1 [Gao, Mingjing; Zhao, Zhen; Lv, Pengyu; Gao, Juntao; Zhang, Michael] Tsinghua Univ, Bioinformat Div, MOE Key Lab Bioinformat, Beijing 100084, Peoples R China.
   [Gao, Mingjing; Zhao, Zhen; Lv, Pengyu; Gao, Juntao; Zhang, Michael] Tsinghua Univ, Dept Automat, Ctr Synthet & Syst Biol, TNLIST, Beijing 100084, Peoples R China.
   [Li, YuFang] JiuYuanTang Pharmaceut Co Ltd, Yuzhou 452570, HeNan Province, Peoples R China.
   [Zhao, Baolu] Chinese Acad Sci, Inst Biophys, Beijing 100101, Peoples R China.
   [Zhang, Michael] Univ Texas Dallas, Ctr Syst Biol, Dept Mol & Cell Biol, Richardson, TX 75083 USA.
   [Gao, Mingjing] BaiYao CaoYuan Biotechnol Ltd, Xuchang City 461000, Peoples R China.
C3 Tsinghua University; Tsinghua University; Chinese Academy of Sciences;
   Institute of Biophysics, CAS; University of Texas System; University of
   Texas Dallas
RP Gao, JT (corresponding author), Tsinghua Univ, Bioinformat Div, MOE Key Lab Bioinformat, Beijing 100084, Peoples R China.
RI Gao, Juntao/LFU-8909-2024
FU National Key Basic Research Project (973 program) [2012CB316503];
   National Natural Science Foundation of China [31361163004, 91019016]
FX This work is supported by National Key Basic Research Project (973
   program, 2012CB316503) and the National Natural Science Foundation of
   China (Nos. 31361163004 and 91019016).
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NR 28
TC 32
Z9 34
U1 1
U2 40
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2213-2317
J9 REDOX BIOL
JI Redox Biol.
PD DEC
PY 2015
VL 6
BP 206
EP 217
DI 10.1016/j.redox.2015.06.013
PG 12
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA CZ8GR
UT WOS:000367338700020
PM 26262997
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Kurajoh, M
   Fukumoto, S
   Yoshida, S
   Akari, S
   Murase, T
   Nakamura, T
   Ishii, H
   Yoshida, H
   Nagata, Y
   Morioka, T
   Mori, K
   Imanishi, Y
   Hirata, K
   Emoto, M
AF Kurajoh, Masafumi
   Fukumoto, Shinya
   Yoshida, Shio
   Akari, Seigo
   Murase, Takayo
   Nakamura, Takashi
   Ishii, Haruka
   Yoshida, Hisako
   Nagata, Yuki
   Morioka, Tomoaki
   Mori, Katsuhito
   Imanishi, Yasuo
   Hirata, Kazuto
   Emoto, Masanori
TI Uric acid shown to contribute to increased oxidative stress level
   independent of xanthine oxidoreductase activity in MedCity21 health
   examination registry
SO SCIENTIFIC REPORTS
LA English
DT Article
ID HOMEOSTASIS MODEL ASSESSMENT; TOTAL ANTIOXIDANT CAPACITY; HIGHLY
   SENSITIVE ASSAY; METABOLIC SYNDROME; HYPERURICEMIA; LIVER; RISK;
   PATHOGENESIS; DISEASE; OXIDASE
AB Uric acid has both antioxidant and pro-oxidant properties in vitro by scavenging and production of reactive oxygen species (ROS). This cross-sectional study examined whether uric acid possesses effects on oxidative stress under physiological conditions independent of xanthine oxidoreductase (XOR), which is involved in uric acid and ROS production. Serum uric acid level was measured, while plasma XOR activity was determined using our high-sensitive assay in 192 participants (91 males, 101 females) who underwent health examinations and were not taking an antihyperuricemic agent. For antioxidant potential and oxidative stress level, biological antioxidant potential (BAP) and derivative of reactive oxygen metabolites (d-ROMs) in serum, respectively, were measured. Median uric acid level and plasma XOR activity were 5.6 mg/dL and 26.1 pmol/h/mL, respectively, and BAP and d-ROMs levels were 2112.8 mu mol/L and 305.5 Carr U, respectively. Multivariable regression analyses revealed no significant association of serum uric acid level with BAP level, whereas serum uric acid level showed a significant association with d-ROMs level independent of plasma XOR activity (p=0.045), which was prominent in females (p=0.036; p for interaction=0.148). Uric acid might contribute to increased oxidative stress independent of XOR activity by increasing ROS production, without affecting ROS scavenging, especially in females.
C1 [Kurajoh, Masafumi; Yoshida, Shio; Morioka, Tomoaki; Imanishi, Yasuo; Emoto, Masanori] Osaka City Univ, Grad Sch Med, Dept Metab Endocrinol & Mol Med, 1-4-3 Asahi Machi, Osaka 5458585, Japan.
   [Fukumoto, Shinya] Osaka City Univ, Dept Premier Prevent Med, Grad Sch Med, Osaka, Japan.
   [Akari, Seigo; Murase, Takayo; Nakamura, Takashi] Sanwa Kagaku Kenkyusho Co Ltd, Dept Res & Dev, Nagoya, Aichi, Japan.
   [Ishii, Haruka; Yoshida, Hisako] Osaka City Univ, Dept Med Stat, Grad Sch Med, Osaka, Japan.
   [Nagata, Yuki] Osaka City Univ, Dept Vasc Med, Grad Sch Med, Osaka, Japan.
   [Mori, Katsuhito] Osaka City Univ, Dept Nephrol, Grad Sch Med, Osaka, Japan.
   [Hirata, Kazuto] Osaka City Univ, Osaka, Japan.
C3 Osaka Metropolitan University; Osaka Metropolitan University; Sanwa
   Kagaku Kenkyusho Co., Ltd.; Osaka Metropolitan University; Osaka
   Metropolitan University; Osaka Metropolitan University; Osaka
   Metropolitan University
RP Kurajoh, M (corresponding author), Osaka City Univ, Grad Sch Med, Dept Metab Endocrinol & Mol Med, 1-4-3 Asahi Machi, Osaka 5458585, Japan.
EM m1155129@med.osaka-cu.ac.jp
RI Nakamura, Takashi/F-4419-2016
OI Ishii, Haruka/0009-0009-1028-0126
FU Sanwa Kagaku Kenkyusho; Osaka City University (OCU) Strategic Research
   Grants; JSPS KAKENHI Grant [18K11132]; Grants-in-Aid for Scientific
   Research [18K11132] Funding Source: KAKEN
FX We thank Maya Yoshida and Akane Utsunomiya for their assistance with the
   imaging procedures. This study was supported by a research grant from
   Sanwa Kagaku Kenkyusho (to M.K.), Osaka City University (OCU) Strategic
   Research Grants presented in 2014, 2015, and 2016 for top priority
   research (to S.F. and K.H.), and a JSPS KAKENHI Grant (Number 18K11132)
   (to S.F.). The funding bodies had no role in study design, data
   collection or analysis, decision to publish, or preparation of the
   manuscript.
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NR 53
TC 66
Z9 68
U1 0
U2 8
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD APR 1
PY 2021
VL 11
IS 1
AR 7378
DI 10.1038/s41598-021-86962-0
PG 9
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA RI3HG
UT WOS:000636797900008
PM 33795813
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Ooi, DJ
   Chan, KW
   Sarega, N
   Alitheen, NB
   Ithnin, H
   Ismail, M
AF Ooi, Der Jiun
   Chan, Kim Wei
   Sarega, Nadarajan
   Alitheen, Noorjahan Banu
   Ithnin, Hairuszah
   Ismail, Maznah
TI Bioprospecting the Curculigoside-Cinnamic Acid-Rich Fraction from
   Molineria latifolia Rhizome as a Potential Antioxidant
   Therapeutic Agent
SO MOLECULES
LA English
DT Article
DE Molineria latifolia rhizome; ethyl acetate fraction;
   curculigoside-cinnamic acid-rich fraction; antioxidant activity;
   oxidative stress; 3T3-L1 preadipocytes
ID H2O2-INDUCED OXIDATIVE STRESS; PROTEIN-PHENOLIC INTERACTIONS;
   PHYTOCHEMICALS; GLYCATION; EXTRACTS; ADIPOGENESIS; ENHANCEMENT;
   POLYPHENOLS; DERIVATIVES; DAMAGE
AB Increasing evidence from both experimental and clinical studies depicts the involvement of oxidative stress in the pathogenesis of various diseases. Specifically, disruption of homeostatic redox balance in accumulated body fat mass leads to obesity-associated metabolic syndrome. Strategies for the restoration of redox balance, potentially by exploring potent plant bioactives, have thus become the focus of therapeutic intervention. The present study aimed to bioprospect the potential use of the curculigoside-cinnamic acid-rich fraction from Molineria latifolia rhizome as an antioxidant therapeutic agent. The ethyl acetate fraction (EAF) isolated from M. latifolia rhizome methanolic extract (RME) contained the highest amount of phenolic compounds, particularly curculigoside and cinnamic acid. EAF demonstrated glycation inhibitory activities in both glucose-and fructose-mediated glycation models. In addition, in vitro chemical-based and cellular-based antioxidant assays showed that EAF exhibited high antioxidant activities and a protective effect against oxidative damage in 3T3-L1 preadipocytes. Although the efficacies of individual phenolics differed depending on the structure and concentration, a correlational study revealed strong correlations between total phenolic contents and antioxidant capacities. The results concluded that enriched phenolic contents in EAF (curculigoside-cinnamic acid-rich fraction) contributed to the overall better reactivity. Our data suggest that this bioactive-rich fraction warrants therapeutic potential against oxidative stress-related disorders.
C1 [Ooi, Der Jiun; Chan, Kim Wei; Sarega, Nadarajan; Ismail, Maznah] Univ Putra Malaysia, Nutri Cosmeceut Nutrigen & Nanodelivery Programme, Lab Mol Biomed, Inst Biosci, Serdang 43400, Malaysia.
   [Alitheen, Noorjahan Banu] Univ Putra Malaysia, Dept Cell & Mol Biol, Fac Biotechnol & Biomol Sci, Serdang 43400, Malaysia.
   [Ithnin, Hairuszah] Univ Putra Malaysia, Dept Pathol, Fac Med & Hlth Sci, Serdang 43400, Malaysia.
   [Ismail, Maznah] Univ Putra Malaysia, Dept Nutr & Dietet, Fac Med & Hlth Sci, Serdang 43400, Malaysia.
C3 Universiti Putra Malaysia; Universiti Putra Malaysia; Universiti Putra
   Malaysia; Universiti Putra Malaysia
RP Ismail, M (corresponding author), Univ Putra Malaysia, Nutri Cosmeceut Nutrigen & Nanodelivery Programme, Lab Mol Biomed, Inst Biosci, Serdang 43400, Malaysia.; Ismail, M (corresponding author), Univ Putra Malaysia, Dept Nutr & Dietet, Fac Med & Hlth Sci, Serdang 43400, Malaysia.
EM ooiderjiun@gmail.com; chankim@upm.edu.my; sarega5166@gmail.com;
   noorjahan@upm.edu.my; hairuszah@upm.edu.my; maznahis@upm.edu.my
RI Alitheen, Noorjahan/AAL-3713-2020; Ooi, Der Jiun/N-3801-2014
OI Ooi, Der Jiun/0000-0002-4896-2351; ISMAIL, MAZNAH/0000-0002-2378-0519;
   Alitheen, Noorjahan Banu/0000-0003-1966-8580; Chan, Kim
   Wei/0000-0003-3028-0800
FU Universiti Putra Malaysia via Research University Grant Scheme
   Initiative 2 [04-02-12-2086RU]; Universiti Putra Malaysia via Research
   University Grant Scheme Initiative 6 [04-02-11-1381RU]
FX This work was supported by Universiti Putra Malaysia via Research
   University Grant Scheme Initiative 2 (Project No. 04-02-12-2086RU) and
   Initiative 6 (Project No. 04-02-11-1381RU). The authors gratefully
   acknowledge the costs of publication covered by the Research Management
   Centre at the Universiti Putra Malaysia and the contribution of Siti
   Muskinah and Norhayati Yusuf for their technical assistance in
   performing HPLC analyses.
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NR 54
TC 15
Z9 15
U1 0
U2 10
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1420-3049
J9 MOLECULES
JI Molecules
PD JUN
PY 2016
VL 21
IS 6
DI 10.3390/molecules21060682
PG 19
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA DP8ON
UT WOS:000378757600008
PM 27322226
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Ostrow, V
   Wu, SF
   Aguilar, A
   Bonner, R
   Suarez, E
   De Luca, F
AF Ostrow, Vlady
   Wu, Shufang
   Aguilar, Alexandra, Jr.
   Bonner, Robert
   Suarez, Elizabeth
   De Luca, Francesco
TI Association between Oxidative Stress and Masked Hypertension in a
   Multi-Ethnic Population of Obese Children and Adolescents
SO JOURNAL OF PEDIATRICS
LA English
DT Article
ID AMBULATORY BLOOD-PRESSURE; INSULIN-RESISTANCE; ANTIOXIDANT STATUS;
   METABOLIC SYNDROME; HYDROGEN-PEROXIDE; VISCERAL FAT; BIOMARKERS;
   ADIPONECTIN; DISEASE; VALUES
AB Objective To evaluate whether oxidative stress is correlated with adiposity, obesity-related metabolic abnormalities, and ambulatory blood pressure (ABP) in a multi-ethnic pediatric population.
   Study design We conducted a prospective study enrolling 42 obese children (age, 12.8 +/- 2.4 years) and 34 non-obese children (age, 11.8 +/- 3.4 years). We measured urine 8-isoprostane and hydrogen peroxide (markers of oxidative stress) in both obese and non-obese groups. In the obese group, we measured the 24-hour ABP and obtained an oral glucose tolerance test, lipid panel, interleukin-6, and tumor necrosis factor-a.
   Results 8-isoprostane and hydrogen peroxide were correlated with body mass index standard deviation score and waist circumference. The mean 8-isoprostane and hydrogen peroxide levels of the obese group were higher than those of the non-obese group. In the subset of obese subjects who underwent ABP monitoring, 8-isoprostane was correlated with mean 24-hour systolic blood pressure: within the obese group, 8-isoprostane was higher in obese children with elevated mean 24-hour systolic blood pressure.
   Conclusions Our findings provide evidence of a significant correlation between oxidative stress, adiposity, and blood pressure in children. Longitudinal studies in a larger population sample are needed to validate the association between elevated urine 8-isoprostane level and cardiovascular risk factors in an obese pediatric population. (J Pediatr 2011; 158:628-33).
C1 [Ostrow, Vlady; Wu, Shufang; Aguilar, Alexandra, Jr.; Suarez, Elizabeth; De Luca, Francesco] St Christophers Hosp Children, Sect Endocrinol & Diabet, Philadelphia, PA 19134 USA.
   [Bonner, Robert] St Christophers Hosp Children, Div Ambulatory Pediat, Philadelphia, PA 19134 USA.
   Drexel Univ, Coll Med, Dept Pediat, Philadelphia, PA 19104 USA.
C3 Drexel University
RP De Luca, F (corresponding author), St Christophers Hosp Children, Sect Endocrinol & Diabet, 3601 A St,Suite 3303, Philadelphia, PA 19134 USA.
EM francesco.deluca@drexelmed.edu
FU Drexel University College of Medicine
FX Supported by a Creight Center Grant provided by Drexel University
   College of Medicine. The authors declare no conflicts of interest.
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NR 37
TC 43
Z9 46
U1 0
U2 8
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0022-3476
EI 1097-6833
J9 J PEDIATR-US
JI J. Pediatr.
PD APR
PY 2011
VL 158
IS 4
BP 628
EP U139
DI 10.1016/j.jpeds.2010.09.081
PG 7
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA 733DS
UT WOS:000288242200024
PM 21075381
DA 2025-06-11
ER

PT J
AU Sandhya, N
   Gokulakrishnan, K
   Ravikumar, R
   Mohan, V
   Balasubramanyam, M
AF Sandhya, Narasimhan
   Gokulakrishnan, Kuppan
   Ravikumar, Radhakrishnan
   Mohan, Viswanathan
   Balasubramanyam, Muthuswamy
TI Association of hypoadiponectinemia with hypoglutathionemia in NAFLD
   subjects with and without type 2 diabetes
SO DISEASE MARKERS
LA English
DT Article
DE Type 2 diabetes; NAFLD; glutathione; adiponectin; oxidative stress
ID FATTY LIVER-DISEASE; URBAN-RURAL EPIDEMIOLOGY; OXIDATIVE DNA-DAMAGE;
   LIPID-PEROXIDATION; METABOLIC SYNDROME; ADIPONECTIN; STRESS;
   STEATOHEPATITIS; COMPLICATIONS; PREVALENCE
AB Objective: The aim of this study is to measure the extent of oxidative stress and to see whether it has any correlation to changes in adiponectin levels in NAFLD subjects with and without Type 2 diabetes.
   Methods: Subjects recruited from the Chennai Urban Rural Epidemiology Study comprise of 1: Normal Glucose Tolerance (NGT) subjects without NAFLD; 2: NGT with NAFLD; 3: Type 2 Diabetic patients [T2DM] without NAFLD and 4: T2DM with NAFLD. Thiobarbituric acid reactive substances (TBARS), protein carbonyl (PCO), glutathione and adiponectin levels were measured by standard methods. Ultrasound of the liver was used to diagnose NAFLD.
   Results: T2DM subjects with NAFLD had significantly (p < 0.001) higher levels of thiobarbituric acid reactive substances (TBARS) and protein carbonyls (PCO) but lower (p < 0.001) GSH/GSSG ratio and adiponectin levels compared to other three groups. The association of hypoadiponectinemia with NAFLD/Type 2 diabetes was significant even after adjusting for age, gender and BMI, but lost when adjusted for parameters of oxidative stress. While palmitate significantly reduced GSH/GSSG ratio in hepatocytes, addition of exogenous recombinant adiponectin restored the GSH/GSSG ratio comparable to those of untreated cells.
   Conclusion: There exists an association of hypoglutathionemia and hypoadiponectinemia in subjects with NAFLD and/or T2DM. In addition to the known beneficial effects, out study also exposes the antioxidant nature of adiponectin.
C1 [Balasubramanyam, Muthuswamy] Madras Diabet Res Fdn, Dept Cell & Mol Biol, Madras 600086, Tamil Nadu, India.
   IDF Ctr Educ, WHO Collaborating Ctr Noncommunicable Dis Prevent, Dr Mohans Diabet Special Ctr, Madras, Tamil Nadu, India.
C3 Madras Diabetes Research Foundation
RP Balasubramanyam, M (corresponding author), Madras Diabet Res Fdn, Dept Cell & Mol Biol, Madras 600086, Tamil Nadu, India.
EM drbalu@mdrf.in
RI Viswanathan, Mohan/C-2321-2009; GOKULAKRISHNAN, KUPPAN/AAT-3244-2020;
   Stefanadis, Christodoulos/ABH-2232-2020
OI Mohan, Viswanathan/0000-0001-5038-6210; Stefanadis,
   Christodoulos/0000-0001-5974-6454; GOKULAKRISHNAN,
   KUPPAN/0000-0003-3167-8239
FU Chennai Willingdon Corporate Foundation, Chennai; Lady Tata Memorial
   Trust; DBT, Government of India
FX We are grateful to the Chennai Willingdon Corporate Foundation, Chennai
   for the financial support provided for the study. We thank the
   epidemiology team members for conducting the CURES field studies. This
   is the 96th publication of CURES [CURES - 96]. Financial assistance from
   DBT, Government of India is greatly acknowledged. SN also acknowledges
   the financial assistance from the Lady Tata Memorial Trust.
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NR 51
TC 10
Z9 10
U1 2
U2 4
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 0278-0240
EI 1875-8630
J9 DIS MARKERS
JI Dis. Markers
PY 2010
VL 29
IS 5
BP 213
EP 221
DI 10.1155/2010/248321
PG 9
WC Biotechnology & Applied Microbiology; Genetics & Heredity; Medicine,
   Research & Experimental; Pathology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Genetics & Heredity; Research &
   Experimental Medicine; Pathology
GA 702CR
UT WOS:000285872700002
PM 21206006
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Crawford, MS
   Gumpricht, E
   Sweazea, KL
AF Crawford, Meli'sa S.
   Gumpricht, Eric
   Sweazea, Karen L.
TI A novel organic mineral complex prevented high fat diet-induced
   hyperglycemia, endotoxemia, liver injury and endothelial dysfunction in
   young male Sprague-Dawley rats
SO PLOS ONE
LA English
DT Article
ID METABOLIC SYNDROME; FULVIC-ACID; OXIDATIVE STRESS; IN-VITRO; OBESITY
AB The prevalence of metabolic syndrome (MetSyn) has risen 35% since 2012 and over two-thirds of Americans exhibit features characterizing this condition (obesity, dyslipidemia, hyperglycemia, insulin resistance and/or endothelial dysfunction). The aim of this study was to evaluate the effects of a novel dietary supplemental organic mineral complex (OMC) on these risk factors in a rodent model of MetSyn. Six-week old male Sprague-Dawley rats were fed either standard chow or a high-fat diet (HFD) composed of 60% kcal from fat for 10 weeks. Rats were also treated with OMC in their drinking water at either 0 mg/mL (control), 0.6 mg/mL, or 3.0 mg/mL. The HFD-treated rats exhibited significantly increased body mass (p<0.05), epididymal fat pad mass (p<0.001), waist circumference (p = 0.010), in addition to elevations in plasma endotoxins (p<0.001), ALT activity (p<0.001), fasting serum glucose (p = 0.025) and insulin concentrations (p = 0.009). OMC did not affect body weight or adiposity induced by the HFD. At the higher dose OMC significantly blunted HFD-induced hyperglycemia (p = 0.021), whereas both low and high doses of OMC prevented HFD-induced endotoxemia (p = 0.002 and <0.001, respectively) and hepatocyte injury (ALT activity, p<0.01). Despite evidence of oxidative stress (elevated urinary H2O2 p = 0.032) in HFD-fed rats, OMC exhibited no demonstrable antioxidative effect. Consistent with prior studies, mesenteric arteries from HFD rats had more uncoupled eNOS (p = 0.006) and iNOS protein expression (p = 0.027) in addition to impaired endothelium-dependent vasodilation that was abrogated by the high dose of OMC (p<0.05). This effect of OMC may be attributed to the high nitrate content of the supplement. These findings suggest that the OMC supplement, particularly at the higher dose, ameliorated several risk factors associated with MetSyn via a non-antioxidant-dependent mechanism.
C1 [Crawford, Meli'sa S.; Sweazea, Karen L.] Arizona State Univ, Sch Life Sci, Tempe, AZ 85281 USA.
   [Gumpricht, Eric] Isagenix Int LLC, Gilbert, AZ USA.
   [Sweazea, Karen L.] Arizona State Univ, Coll Hlth Solut, Phoenix, AZ 85004 USA.
C3 Arizona State University; Arizona State University-Tempe; Arizona State
   University; Arizona State University-Downtown Phoenix
RP Sweazea, KL (corresponding author), Arizona State Univ, Sch Life Sci, Tempe, AZ 85281 USA.; Sweazea, KL (corresponding author), Arizona State Univ, Coll Hlth Solut, Phoenix, AZ 85004 USA.
EM Karen.Sweazea@asu.edu
RI Sweazea, Karen/AAT-4151-2020
OI Gumpricht, Eric/0000-0001-6034-3484; Sweazea, Karen/0000-0003-0345-4086
FU Isagenix International, LLC
FX This study was funded by a grant from Isagenix International, LLC (to
   KLS). The funder provided support in the form of salaries for authors
   (MSC, EG) but did not have a role in the study design, data collection
   and analysis, decision to publish, or preparation of the first draft of
   the manuscript. The specific roles of these authors are articulated in
   the 'author contributions' section.
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NR 39
TC 4
Z9 5
U1 0
U2 2
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD AUG 26
PY 2019
VL 14
IS 8
AR e0221392
DI 10.1371/journal.pone.0221392
PG 17
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA IW5UR
UT WOS:000485044000013
PM 31449541
OA Green Submitted, gold, Green Published
DA 2025-06-11
ER

PT J
AU Padgett, CA
   Bátori, RK
   Speese, AC
   Rosewater, CL
   Bush, WB
   Derella, CC
   Haigh, SB
   Sellers, HG
   Corley, ZL
   West, MA
   Mintz, JD
   Ange, BB
   Harris, RA
   Brands, MW
   Fulton, DJR
   Stepp, DW
AF Padgett, Caleb A.
   Batori, Robert K.
   Speese, Andrew C.
   Rosewater, Cody L.
   Bush, Weston B.
   Derella, Cassandra C.
   Haigh, Stephen B.
   Sellers, Hunter G.
   Corley, Zachary L.
   West, Madison A.
   Mintz, James D.
   Ange, Brittany B.
   Harris, Ryan A.
   Brands, Michael W.
   Fulton, David J. R.
   Stepp, David W.
TI Galectin-3 Mediates Vascular Dysfunction in Obesity by Regulating NADPH
   Oxidase 1
SO ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
LA English
DT Article
DE galectin-3; insulin; metabolic syndrome; NADPH oxidases; obesity
ID ENDOTHELIAL DYSFUNCTION; CARDIOVASCULAR-DISEASE; OXIDATIVE STRESS;
   NITRIC-OXIDE; RISK; MICE; ATHEROSCLEROSIS; DELETION; RECEPTOR; EVENTS
AB BACKGROUND: Obesity is associated with increased risk of cardiovascular disease, but underlying mechanisms remain elusive. Metabolic dysfunction, especially hyperglycemia, is thought to be a major contributor, but how glucose impacts vascular function is unclear. GAL3 (galectin-3) is a sugar-binding lectin upregulated by hyperglycemia, but its role as a causative mechanism of cardiovascular disease remains poorly understood. Therefore, the objective of this study was to determine the role of GAL3 in regulating microvascular endothelial vasodilation in obesity.
   METHODS: GAL3 was measured and found to be markedly increased in the plasma of overweight and obese patients, as well as in the microvascular endothelium of diabetic patients. To investigate causative mechanisms in cardiovascular disease, mice deficient in GAL3 were bred with obese db/db mice to generate lean, lean GAL3 knockout, obese, and obese GAL3 knockout genotypes. Endothelial cell-specific GAL3 knockout mice with novel AAV-induced obesity recapitulated wholebody knockout studies to confirm cell specificity.
   RESULTS: Deletion of GAL3 did not alter body mass, adiposity, or plasma indices of glycemia and lipidemia, but levels of plasma reactive oxygen species as assessed by plasma thiobarbituric acid reactive substances were normalized in obese GAL3 knockout mice. Obese mice exhibited profound endothelial dysfunction and hypertension, both of which were rescued by GAL3 deletion. Isolated microvascular endothelial cells from obese mice had increased expression of NOX1 (nicotinamide adenine dinucleotide phosphate oxidase 1), which we have previously shown to contribute to increased oxidative stress and endothelial dysfunction, which was normalized in microvascular endothelium from mice lacking GAL3. Cell-specific deletion confirmed that endothelial GAL3 regulates obesity-induced NOX1 overexpression and subsequent microvascular function. Furthermore, improvement of metabolic syndrome by increasing muscle mass, improving insulin signaling, or treating with metformin decreased microvascular GAL3, and thereby NOX1, expression levels.
   CONCLUSIONS: Deletion of GAL3 normalizes microvascular endothelial function in obese db/db mice, likely through a NOX1-mediated mechanism. Pathological levels of GAL3, and in turn NOX1, are amenable to improvements in metabolic status, presenting a potential therapeutic target to ameliorate pathological cardiovascular consequences of obesity.
C1 [Padgett, Caleb A.; Batori, Robert K.; Speese, Andrew C.; Rosewater, Cody L.; Haigh, Stephen B.; Sellers, Hunter G.; Corley, Zachary L.; West, Madison A.; Mintz, James D.; Fulton, David J. R.; Stepp, David W.] Augusta Univ, Med Coll Georgia, Vasc Biol Ctr, Augusta, GA USA.
   [Bush, Weston B.; Derella, Cassandra C.; Harris, Ryan A.; Brands, Michael W.; Stepp, David W.] Augusta Univ, Dept Physiol, Med Coll Georgia, Augusta, GA USA.
   [Ange, Brittany B.] Augusta Univ, Dept Surg, Med Coll Georgia, Augusta, GA USA.
   [Fulton, David J. R.] Augusta Univ, Dept Pharmacol & Toxicol, Med Coll Georgia, Augusta, GA USA.
   [Derella, Cassandra C.; Harris, Ryan A.] Augusta Univ, Georgia Prevent Inst, Med Coll Georgia, Augusta, GA USA.
C3 University System of Georgia; Augusta University; University System of
   Georgia; Augusta University; University System of Georgia; Augusta
   University; University System of Georgia; Augusta University; University
   System of Georgia; Augusta University
RP Stepp, DW (corresponding author), Augusta Univ, Med Coll Georgia, 1460 Laney Walker Blvd, Augusta, GA 30907 USA.
EM dstepp@augusta.edu
RI Batori, Robert/I-4846-2017; Harris, Ryan/F-8880-2013; Stepp,
   David/F-4250-2011
OI West, Madison/0000-0002-9338-5872; Derella,
   Cassandra/0000-0003-1649-9347; Batori, Robert
   Karoly/0000-0002-1400-6732; Sellers, Hunter/0000-0001-8994-9404;
   Padgett, Caleb/0000-0003-1046-344X
FU National Institutes of Health (NIH) [1F31HL154646]; NIH [1R01HL147159]
FX C.A. Padgett is supported by the National Institutes of Health (NIH)
   1F31HL154646. D.W. Stepp and D.J.R. Fulton are supported by NIH
   1R01HL147159.
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NR 55
TC 5
Z9 5
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1079-5642
EI 1524-4636
J9 ARTERIOSCL THROM VAS
JI Arterioscler. Thromb. Vasc. Biol.
PD OCT
PY 2023
VL 43
IS 10
BP E381
EP E395
DI 10.1161/ATVBAHA.123.319476
PG 15
WC Hematology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Hematology; Cardiovascular System & Cardiology
GA Z9VJ3
UT WOS:001115480100001
PM 37586054
OA Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Sánchez, A
   Contreras, C
   Martínez, MP
   Climent, B
   Benedito, S
   García-Sacristán, A
   Hernández, M
   Prieto, D
AF Sanchez, Ana
   Contreras, Cristina
   Martinez, Maria Pilar
   Climent, Belen
   Benedito, Sara
   Garcia-Sacristan, Albino
   Hernandez, Medardo
   Prieto, Dolores
TI Role of Neural NO Synthase (nNOS) Uncoupling in the Dysfunctional
   Nitrergic Vasorelaxation of Penile Arteries from Insulin-Resistant Obese
   Zucker Rats
SO PLOS ONE
LA English
DT Article
ID NITRIC-OXIDE SYNTHASE; ENDOTHELIUM-DEPENDENT RELAXATION; KINASE
   SIGNALING PATHWAY; ALPHA-LIPOIC ACID; CORPUS-CAVERNOSUM; ERECTILE
   DYSFUNCTION; DIABETES-MELLITUS; CA2+ SENSITIZATION; MOUSE PENIS; K+
   CHANNELS
AB Objective: Erectile dysfunction (ED) is considered as an early sign of vascular disease due to its high prevalence in patients with cardiovascular risk factors. Endothelial and neural dysfunction involving nitric oxide (NO) are usually implicated in the pathophysiology of the diabetic ED, but the underlying mechanisms are unclear. The present study assessed the role of oxidative stress in the dysfunctional neural vasodilator responses of penile arteries in the obese Zucker rat (OZR), an experimental model of metabolic syndrome/prediabetes.
   Methods and Results: Electrical field stimulation (EFS) under non-adrenergic non-cholinergic (NANC) conditions evoked relaxations that were significantly reduced in penile arteries of OZR compared with those of lean Zucker rats (LZR). Blockade of NO synthase (NOS) inhibited neural relaxations in both LZR and OZR, while saturating concentrations of the NOS substrate L-arginine reversed the inhibition and restored relaxations in OZR to levels in arteries from LZR. nNOS expression was unchanged in arteries from OZR compared to LZR and nNOS selective inhibition decreased the EFS relaxations in LZR but not in OZR, while endothelium removal did not alter these responses in either strain. Superoxide anion production and nitro-tyrosine immunostaining were elevated in the erectile tissue from OZR. Treatment with the NADPH oxidase inhibitor apocynin or acute incubation with the NOS cofactor tetrahydrobiopterin (BH4) restored neural relaxations in OZR to levels in control arteries, while inhibition of the enzyme of BH4 synthesis GTP-cyclohydrolase (GCH) reduced neural relaxations in arteries from LZR but not OZR. The NO donor SNAP induced decreases in intracellular calcium that were impaired in arteries from OZR compared to controls.
   Conclusions: The present study demonstrates nitrergic dysfunction and impaired neural NO signalling due to oxidative stress and nNOS uncoupling in penile arteries under conditions of insulin resistance. This dysfunction likely contributes to the metabolic syndrome-associated ED, along with the endothelial dysfunction also involving altered NO signalling.
C1 [Sanchez, Ana; Contreras, Cristina; Climent, Belen; Benedito, Sara; Garcia-Sacristan, Albino; Hernandez, Medardo; Prieto, Dolores] Univ Complutense Madrid, Fac Farm, Dept Fisiol, Madrid, Spain.
   [Martinez, Maria Pilar] Univ Complutense Madrid, Fac Farm, Dept Anat & Anat Patol Comparadas, Madrid, Spain.
C3 Complutense University of Madrid; Complutense University of Madrid
RP Sánchez, A (corresponding author), Univ Complutense Madrid, Fac Farm, Dept Fisiol, Madrid, Spain.
EM dprieto@farm.ucm.es
RI Contreras, Cristina/N-7257-2019; BENEDITO, SARA/H-9730-2015; Martinez,
   Pilar/E-8591-2016; Climent, Belen/P-2416-2015; PRIETO,
   DOLORES/S-8172-2018
OI BENEDITO, SARA/0000-0001-9660-2409; Contreras,
   Cristina/0000-0002-7015-7922; Martinez, Pilar/0000-0001-9063-3191;
   Climent, Belen/0000-0003-0852-9227; PRIETO, DOLORES/0000-0001-7049-5991
FU Spanish Minister of Science and Innovation [SAF2009-10448]
FX This study was supported by Grant no SAF2009-10448 from the Spanish
   Minister of Science and Innovation. The funders had no role in study
   design, data collection and analysis, decision to publish, or
   preparation of the manuscript.
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NR 55
TC 43
Z9 49
U1 0
U2 8
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD APR 23
PY 2012
VL 7
IS 4
AR e36027
DI 10.1371/journal.pone.0036027
PG 12
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 959UP
UT WOS:000305341000083
PM 22540017
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Hasan, S
   Amin, MAI
   Mia, M
   Khatun, S
   Arafat, Y
   Gofur, MR
   Islam, MM
   Hosen, ME
   Almaary, KS
   Wondmie, GF
   Islam, A
   Rahman, M
   Bourhia, M
AF Hasan, Sohel
   Amin, Md Aminul Islam
   Mia, Masum
   Khatun, Sumaiya
   Arafat, Yesir
   Gofur, Md Royhan
   Islam, Md Mahmudul
   Hosen, Md Eram
   Almaary, Khalid S.
   Wondmie, Gezahign Fentahun
   Islam, Amirul
   Rahman, Matiar
   Bourhia, Mohammed
TI Yogurt Supplementation Can Ameliorate Fatty Liver Diseases and Metabolic
   Syndrome in High Fat-Induced Conditions in Mice
SO FOOD SCIENCE & NUTRITION
LA English
DT Article
DE hepatic steatosis; high-fat diet; LD biogenesis; LD genes; lipid
   metabolism; therapeutic agents
ID LACTIC-ACID BACTERIA; DIET-INDUCED OBESITY; LACTOBACILLUS-ACIDOPHILUS;
   OXIDATIVE STRESS; GUT MICROBIOTA; CHOLESTEROL; PROBIOTICS; INFLAMMATION;
   PRODUCTS; TRAFFICKING
AB Hepatic steatosis/non-alcoholic fatty liver disease is a major public health delinquent caused by the excess deposition of lipid into lipid droplets (LDs) as well as metabolic dysregulation. Hepatic cells buildup with more fat molecules when a person takes high fat diet that is excessive than the body can handle. At present, millions of people in the world are affected by this problem. So, it is very important to know the effects of factors responsible for the disease. Here, the role of lipid droplet (LD) biogenesis and metabolism was analyzed and intended to investigate if defects in biogenesis/metabolic enzymes are responsible for the accumulation of lipids other than LDs in fatty liver disease in high-fat-induced conditions in mice model. To explore it, high-fat diet (HFD), fast food (FF), and soft drinks (SD) were administered to wild-type Swiss albino mice for 14 weeks following yogurt supplementation. After experimental period, glucose tolerance, enzyme function, lipid profile, plasma biochemistry, and other analytical tests were analyzed by auto-analyzer including different oxidative stress markers. Lipids from hepatic tissues were extracted, and purified by Floatation Assay and subsequently analyzed by different biochemical and chromatographic techniques. Histological architecture of hepatocytes was performed using Zeiss microscope. Finally, increased amount of lipids biogenesis/accumulation was found in liver tissues that causes Fatty liver disease. Significantly, HFD, FF, and SD were identified as factors for the increased LD biogenesis and or lipid metabolic disorder. Nevertheless, yogurt supplementation can homeostasis those LD formation and metabolic syndrome as it increases the down regulation of lipid biogenesis as well as lipid metabolic rate. So, yogurt supplementation was considered as a novel agent for decreasing LD biogenesis as well as excessive accumulation of fat in hepatocytes which can be used as therapeutics for the treatment of NAFLD.
C1 [Hasan, Sohel; Amin, Md Aminul Islam; Mia, Masum; Khatun, Sumaiya; Arafat, Yesir; Islam, Amirul; Rahman, Matiar] Univ Rajshahi, Dept Biochem & Mol Biol, Mol & Biomed Res Lab MBRL, Rajshahi, Bangladesh.
   [Gofur, Md Royhan] Univ Rajshahi, Dept Vet & Anim Sci, Rajshahi, Bangladesh.
   [Islam, Md Mahmudul] Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, State Key Lab Resp Dis, Guangzhou, Peoples R China.
   [Hosen, Md Eram] Univ Rajshahi, Shaheed Shamsuzzoha Inst Biosci, Dept Microbiol, Rajshahi, Bangladesh.
   [Almaary, Khalid S.] King Saud Univ, Coll Sci, Dept Bot & Microbiol, Riyadh, Saudi Arabia.
   [Wondmie, Gezahign Fentahun] Bahir Dar Univ, Dept Biol, Bahir Dar, Ethiopia.
   [Bourhia, Mohammed] Ibn Zohr Univ, Fac Sci, Lab Biotechnol & Nat Resources Valorizat, Agadir, Morocco.
C3 University of Rajshahi; University of Rajshahi; State Key Laboratory of
   Respiratory Disease; Chinese Academy of Sciences; Guangzhou Institute of
   Biomedicine & Health, CAS; University of Rajshahi; King Saud University;
   Bahir Dar University; Ibn Zohr University of Agadir
RP Hasan, S (corresponding author), Univ Rajshahi, Dept Biochem & Mol Biol, Mol & Biomed Res Lab MBRL, Rajshahi, Bangladesh.; Wondmie, GF (corresponding author), Bahir Dar Univ, Dept Biol, Bahir Dar, Ethiopia.
EM sohel_bio@ru.ac.bd; resercherfent@gmail.com
RI Wondmie, Gezahign/KLC-8957-2024; Hosen, Md. Eram/JGL-7246-2023; Almaary,
   Khalid/MFI-1183-2025
OI Hosen, Md. Eram/0000-0001-5137-9717; Islam, Mohammad
   Amirul/0000-0002-8437-9374
FU Faculty of Science, Rajshahi University; ICDDRB, Dhaka; BCSIR
   [2006/5/52/rusci-39/2023-24]; Faculty of Science [1654/15-66/2022-23,
   RSP2024R189]; University Grants Commission (UGC); King Saud University,
   Riyadh, Saudi Arabia
FX The authors are grateful to ICDDRB, Dhaka; BCSIR, Rajshahi; and I.B.Sc,
   R.U. for helping in this research. Also, thankful to the Faculty of
   Science (2006/5/52/rusci-39/2023-24), Rajshahi University, and the
   University Grants Commission (UGC) (1654/15-66/2022-23), Bangladesh, for
   supporting and providing research funds. The authors extend their
   appreciation to the Researchers Supporting Project number (RSP2024R189),
   King Saud University, Riyadh, Saudi Arabia.
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NR 59
TC 0
Z9 0
U1 4
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2048-7177
J9 FOOD SCI NUTR
JI Food Sci. Nutr.
PD JAN
PY 2025
VL 13
IS 1
DI 10.1002/fsn3.4650
EA DEC 2024
PG 19
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA S2D7P
UT WOS:001370640600001
PM 39803213
OA Green Published
DA 2025-06-11
ER

PT J
AU Kuzuya, M
   Ando, F
   Iguchi, A
   Shimokata, H
AF Kuzuya, Masafumi
   Ando, Fujiko
   Iguchi, Akihisa
   Shimokata, Hiroshi
TI Glutathione peroxidase 1 Pro198Leu variant contributes to the metabolic
   syndrome in men in a large Japanese cohort
SO AMERICAN JOURNAL OF CLINICAL NUTRITION
LA English
DT Article
ID INCREASED OXIDATIVE STRESS; INSULIN-RESISTANCE; ALCOHOL-CONSUMPTION;
   BREAST-CANCER; LUNG-CANCER; GLUTATHIONE; RISK; POLYMORPHISM; SELENIUM;
   GLUCOSE
AB Background: There has been much interest in the role of free radicals and oxidative stress in the pathogenesis of metabolic syndrome (MetS). Cellular antioxidant enzymes such as glutathione peroxidase 1(GPX1) play a central role in the control of reactive oxygen species.
   Objective: We examined whether GPX1 polymorphism (Pro198Leu) is associated with MetS as well as with each component of MetS.
   Design: The study was a cross-sectional analysis of randomly selected, community-dwelling Japanese persons aged 40-70 y (1128 M, 1105 F).
   Results: The genotype frequencies for the GPX1 Pro198Leu polymorphism in this cohort were 0.846, 0.151, and 0.003 for CC, CT, and TT, respectively. The CT/TTgenotypes had significantly higher waist-hip ratios, triacylglycerol concentrations, homeostasis model assessment for P-cell function, and systolic and diastolic blood pressures in men (P = 0.045, 0.012, 0.011, 0.004, and 0.003, respectively) than did the CC genotype; the CC/TT genotypes also had higher insulin in both sexes (P = 0.019 for men, P = 0.010 for women) and higher body fat mass (P = 0.027) and homeostasis model assessment for insulin resistance (P = 0.008) in women. The CT/TT genotypes showed significant association with higher prevalence of MetS as defined by 2 commonly used criteria in men [odds ratio (OR): 2.02; 95% CI: 1.30, 3.15 by the International Diabetes Federation criteria; OR: 1.49; 95% CI: 1.02, 2.18 by the modified National Cholesterol Education Program criteria) but not in women. The CT/TTgenotypes showed a higher prevalence of central obesity (OR: 1.93; 95% CI: 1.31, 2.85) and hypertriglyceridemia (OR: 1.52; 95% CI: 1.08, 2.15) in men but not in women; there were no differences in other components of MetS between the CC and CT/TT genotypes in either sex.
   Conclusion: GPX1 Pro198Leu variants are associated with the prevalence of MetS in Japanese men but not in women.
C1 [Kuzuya, Masafumi; Iguchi, Akihisa] Nagoya Univ, Grad Sch Med, Dept Geriatr, Showa Ku, Nagoya, Aichi 4668550, Japan.
   [Ando, Fujiko; Shimokata, Hiroshi] Natl Inst Longev Sci, Dept Epidemiol, Aichi, Japan.
C3 Nagoya University
RP Kuzuya, M (corresponding author), Nagoya Univ, Grad Sch Med, Dept Geriatr, Showa Ku, 65 Tsuruma Cho, Nagoya, Aichi 4668550, Japan.
EM kuzuya@med.nagoya-u.ac.jp
RI Kuzuya, Masafumi/I-1583-2012
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NR 35
TC 53
Z9 59
U1 0
U2 2
PU AMER SOC CLINICAL NUTRITION
PI BETHESDA
PA 9650 ROCKVILLE PIKE, SUBSCRIPTIONS, RM L-3300, BETHESDA, MD 20814-3998
   USA
SN 0002-9165
J9 AM J CLIN NUTR
JI Am. J. Clin. Nutr.
PD JUN
PY 2008
VL 87
IS 6
BP 1939
EP 1944
DI 10.1093/ajcn/87.6.1939
PG 6
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 313ET
UT WOS:000256724600047
PM 18541588
OA Bronze
DA 2025-06-11
ER

PT J
AU Cao, J
   Singh, SP
   McClung, JA
   Joseph, G
   Vanella, L
   Barbagallo, I
   Jiang, HL
   Falck, JR
   Arad, M
   Shapiro, JI
   Abraham, NG
AF Cao, Jian
   Singh, Shailendra P.
   McClung, John A.
   Joseph, Gregory
   Vanella, Luca
   Barbagallo, Ignazio
   Jiang, Houli
   Falck, John R.
   Arad, Michael
   Shapiro, Joseph I.
   Abraham, Nader G.
TI EET intervention on Wnt1, NOV, and HO-1 signaling prevents
   obesity-induced cardiomyopathy in obese mice
SO AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
LA English
DT Article
DE cardiomyopathy; metabolic syndrome; oxidative stress; hypertension;
   myocardial biology; nephroblastoma overexpressed; heme oxygenase-1
ID SOLUBLE EPOXIDE HYDROLASE; HIGH-FAT DIET; EPOXYEICOSATRIENOIC ACIDS;
   MITOCHONDRIAL BIOGENESIS; INSULIN-RESISTANCE; ENDOTHELIAL-CELLS;
   OXIDATIVE STRESS; HEME OXYGENASE-1; 11,12-EPOXYEICOSATRIENOIC ACID;
   CARDIOVASCULAR-DISEASE
AB We have previously reported that epoxyeicosatrienoic acid (EET) has multiple beneficial effects on vascular function; in addition to its antiapoptotic action, it increases insulin sensitivity and inhibits inflammation. To uncover the signaling mechanisms by which EET reduces cardiomyopathy, we hypothesized that EET infusion might ameliorate obesity-induced cardiomyopathy by improving heme oxygenase (HO)-1, Wnt1, thermogenic gene levels, and mitochondrial integrity in cardiac tissues and improved pericardial fat phenotype. EET reduced levels of fasting blood glucose and proinflammatory adipokines, including nephroblastoma overexpressed (NOV) signaling, while increasing echocardiographic fractional shortening and O-2 consumption. Of interest, we also noted a marked improvement in mitochondrial integrity, thermogenic genes, and Wnt 1 and HO-1 signaling mechanisms. Knockout of peroxisome proliferator-activated receptor-gamma coactivator-1 alpha (PGC-1 alpha) in EET-treated mice resulted in a reversal of these beneficial effects including a decrease in myocardial Wnt1 and HO-1 expression and an increase in NOV. To further elucidate the effects of EET on pericardial adipose tissues, we observed EET treatment increases in adiponectin, PGC-1 alpha, phospho-AMP-activated protein kinase, insulin receptor phosphorylation, and thermogenic genes, resulting in a "browning" pericardial adipose phenotype under high-fat diets. Collectively, these experiments demonstrate that an EET agonist increased Wnt1 and HO-1 signaling while decreasing NOV pathways and the progression of cardiomyopathy. Furthermore, this report presents a portal into potential therapeutic approaches for the treatment of heart failure and metabolic syndrome.
   NEW & NOTEWORTHY The mechanism by which EET acts on obesity-induced cardiomyopathy is unknown. Here, we describe a previously unrecognized function of EET infusion that inhibits nephroblastoma overexpressed (NOV) levels and activates Wnt1, hence identifying NOV inhibition and enhanced Wnt1 expression as novel pharmacological targets for the prevention and treatment of cardiomyopathy and heart failure.
   Listen to this article's corresponding podcast at http://ajpheart.physiology.org/content/early/2017/05/31/ajpheart.00093.2017.
C1 [Cao, Jian; Singh, Shailendra P.; McClung, John A.; Joseph, Gregory; Jiang, Houli; Abraham, Nader G.] New York Med Coll, Dept Med, Valhalla, NY 10595 USA.
   [Cao, Jian; Singh, Shailendra P.; McClung, John A.; Joseph, Gregory; Jiang, Houli; Abraham, Nader G.] New York Med Coll, Dept Pharmacol, Valhalla, NY 10595 USA.
   [Cao, Jian] Chinese Peoples Liberat Army Gen Hosp, Beijing, Peoples R China.
   [Vanella, Luca; Barbagallo, Ignazio] Univ Catania, Dept Drug Sci, Sect Biochem, Catania, Italy.
   [Falck, John R.] Univ Texas Southwestern Med Ctr Dallas, Dept Biochem, Dallas, TX 75390 USA.
   [Arad, Michael] Tel Aviv Univ, Leviev Heart Ctr, Tel Aviv, Israel.
   [Shapiro, Joseph I.; Abraham, Nader G.] Marshall Univ, Joan C Edwards Sch Med, Huntington, WV USA.
C3 New York Medical College; New York Medical College; Chinese People's
   Liberation Army General Hospital; University of Catania; University of
   Texas System; University of Texas Southwestern Medical Center Dallas;
   Tel Aviv University; Marshall University
RP Abraham, NG (corresponding author), New York Med Coll, Dept Med, Valhalla, NY 10595 USA.; Abraham, NG (corresponding author), New York Med Coll, Dept Pharmacol, Valhalla, NY 10595 USA.
EM nader_abraham@nymc.edu
RI Vanella, Luca/J-7354-2016; Falck, John/B-3030-2011; McClung,
   John/KUF-2061-2024; SINGH, SHAILENDRA PRATAP/R-8524-2018
OI Barbagallo, Ignazio/0000-0002-7761-0662; SINGH, SHAILENDRA
   PRATAP/0000-0003-2996-0374
FU National Heart, Lung, and Blood Institute [HL-34300, HL-109015];
   Renfield Foundation; Rockefeller University
FX This work was supported by National Heart, Lung, and Blood Institute
   Grants HL-34300 to N. G. Abraham and HL-109015 to J. I. Shapiro, and by
   The Renfield Foundation, The Rockefeller University.
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NR 61
TC 53
Z9 56
U1 0
U2 7
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0363-6135
EI 1522-1539
J9 AM J PHYSIOL-HEART C
JI Am. J. Physiol.-Heart Circul. Physiol.
PD AUG
PY 2017
VL 313
IS 2
BP H368
EP H380
DI 10.1152/ajpheart.00093.2017
PG 13
WC Cardiac & Cardiovascular Systems; Physiology; Peripheral Vascular
   Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Physiology
GA FF0TX
UT WOS:000408615100019
PM 28576832
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Halperin, F
   Ding, SA
   Simonson, DC
   Panosian, J
   Goebel-Fabbri, A
   Wewalka, M
   Hamdy, O
   Abrahamson, M
   Clancy, K
   Foster, K
   Lautz, D
   Vernon, A
   Goldfine, AB
AF Halperin, Florencia
   Ding, Su-Ann
   Simonson, Donald C.
   Panosian, Jennifer
   Goebel-Fabbri, Ann
   Wewalka, Marlene
   Hamdy, Osama
   Abrahamson, Martin
   Clancy, Kerri
   Foster, Kathleen
   Lautz, David
   Vernon, Ashley
   Goldfine, Allison B.
TI Roux-en-Y Gastric Bypass Surgery or Lifestyle With Intensive Medical
   Management in Patients With Type 2 Diabetes Feasibility and 1-Year
   Results of a Randomized Clinical Trial
SO JAMA SURGERY
LA English
DT Article
ID LONG-TERM MORTALITY; BARIATRIC SURGERY; OBESE-PATIENTS; GLUCOSE CONTROL;
   INTERVENTION; WEIGHT; THERAPY; COMPLICATIONS; REDUCTION; OUTCOMES
AB IMPORTANCE Emerging data support bariatric surgery as a therapeutic strategy for management of type 2 diabetes mellitus.
   OBJECTIVE To test the feasibility of methods to conduct a larger multisite trial to determine the long-term effect of Roux-en-Y gastric bypass (RYGB) surgery compared with an intensive diabetes medical and weight management (Weight Achievement and Intensive Treatment [Why WAIT]) program for type 2 diabetes.
   DESIGN, SETTING, AND PARTICIPANTS A 1-year pragmatic randomized clinical trial was conducted in an academic medical institution. Participants included persons aged 21 to 65 years with type 2 diabetes diagnosed more than 1 year before the study; their body mass index was 30 to 42 (calculated as weight in kilograms divided by height in meters squared) and hemoglobin A(1c) (HbA(1c)) was greater than or equal to 6.5%. All participants were receiving antihyperglycemic medications.
   INTERVENTIONS RYGB (n = 19) or Why WAIT (n = 19) including 12 weekly multidisciplinary group lifestyle, medical, and educational sessions with monthly follow-up thereafter.
   MAIN OUTCOMES AND MEASURES Proportion of patients with fasting plasma glucose levels less than 126 mg/dL and HbA(1c) less than 6.5%, measures of cardiometabolic health, and patient-reported outcomes.
   RESULTS At 1 year, the proportion of patients achieving HbA(1c) below 6.5% and fasting glucose below 126 mg/dL was higher following RYGB than Why WAIT (58% vs 16%, respectively; P = .03). Other outcomes, including HbA(1c), weight, waist circumference, fat mass, lean mass, blood pressure, and triglyceride levels, decreased and high-density lipoprotein cholesterol increased more after RYGB compared with Why WAIT. Improvement in cardiovascular risk scores was greater in the surgical group. At baseline the participants exhibited moderately low self-reported quality-of-life scores reflected by Short Form-36 total, physical health, and mental health, as well as high Impact of Weight on Quality of Life-Lite and Problem Areas in Diabetes health status scores. At 1 year, improvements in Short Form-36 physical and mental health scores and Problem Areas in Diabetes scores did not differ significantly between groups. The Impact of Weight on Quality of Life-Lite score improved more with RYGB and correlated with greater weight loss compared with Why WAIT.
   CONCLUSIONS AND RELEVANCE In obese patients with type 2 diabetes, RYGB produces greater weight loss and sustained improvements in HbA(1c) and cardiometabolic risk factors compared with medical management, with emergent differences over 1 year. Both treatments improve general quality-of-life measures, but RYGB provides greater improvement in the effect of weight on quality of life. These differences may help inform therapeutic decisions for diabetes and weight loss strategies in obese patients with type 2 diabetes until larger randomized trials are performed.
C1 [Halperin, Florencia; Simonson, Donald C.] Harvard Univ, Sch Med, Brigham & Womens Hosp, Div Endocrinol Diabet & Hypertens, Boston, MA 02215 USA.
   [Panosian, Jennifer; Goebel-Fabbri, Ann; Wewalka, Marlene; Hamdy, Osama; Abrahamson, Martin; Foster, Kathleen; Goldfine, Allison B.] Harvard Univ, Sch Med, Joslin Diabet Ctr, Div Res, Boston, MA 02215 USA.
   [Clancy, Kerri; Lautz, David; Vernon, Ashley] Harvard Univ, Sch Med, Brigham & Womens Hosp, Ctr Metab & Bariatr Surg, Boston, MA 02215 USA.
C3 Harvard University; Harvard Medical School; Harvard University Medical
   Affiliates; Brigham & Women's Hospital; Harvard University; Harvard
   University Medical Affiliates; Joslin Diabetes Center, Inc.; Harvard
   Medical School; Harvard University; Harvard University Medical
   Affiliates; Brigham & Women's Hospital; Harvard Medical School
RP Goldfine, AB (corresponding author), Harvard Univ, Sch Med, Joslin Diabet Ctr, Div Res, One Joslin Pl, Boston, MA 02215 USA.
EM allison.goldfine@joslin.harvard.edu
OI hamdy, osama/0000-0002-1919-0268
FU National Institute of Diabetes and Digestive and Kidney Diseases
   [RC1-DK086918, R56-DK095451, P30-DKO03836]; Osterreichischer
   Austausdienst [ICM-2010-02797]; Herbert Graetz Fund
FX This work was supported by National Institute of Diabetes and Digestive
   and Kidney Diseases grants RC1-DK086918, R56-DK095451, and P30-DKO03836;
   the Marietta Blau grant ICM-2010-02797 from the Osterreichischer
   Austausdienst; and the Herbert Graetz Fund. Covidien provided funds for
   the surgical costs of participants with BMI less than 35 who were
   randomized to undergo surgery; Lifescan, a Division of Johnson &
   Johnson, provided home glucose monitoring supplies; Nestle Nutrition Inc
   provided Boost; and Mercodia provided assay materials.
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NR 41
TC 188
Z9 194
U1 0
U2 12
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 2168-6254
EI 2168-6262
J9 JAMA SURG
JI JAMA Surg.
PD JUL
PY 2014
VL 149
IS 7
BP 716
EP 726
DI 10.1001/jamasurg.2014.514
PG 11
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA AN8DV
UT WOS:000340833800019
PM 24899464
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Hernández-Mijares, A
   García-Malpartida, K
   Solá-Izquierdo, E
   Bañuls, C
   Rocha, M
   Gómez-Martínez, MJ
   Mármol, R
   Víctor, VM
AF Hernandez-Mijares, Antonio
   Garcia-Malpartida, Katherine
   Sola-Izquierdo, Eva
   Banuls, Celia
   Rocha, Milagros
   Jesus Gomez-Martinez, Manuel
   Marmol, Rosario
   Manuel Victor, Victor
TI Testosterone Levels in Males with Type 2 Diabetes and Their Relationship
   with Cardiovascular Risk Factors and Cardiovascular Disease
SO JOURNAL OF SEXUAL MEDICINE
LA English
DT Article
DE Hypogonadism; Testosterone; Type 2 Diabetes; Cardiovascular Risk
   Factors; Metabolic Syndrome
ID HORMONE-BINDING GLOBULIN; ENDOGENOUS SEX-HORMONES; LATE-ONSET
   HYPOGONADISM; HEALTHY ADULT MEN; ERECTILE DYSFUNCTION;
   INSULIN-RESISTANCE; OLDER MEN; SERUM TESTOSTERONE; HYPOGONADOTROPIC
   HYPOGONADISM; METABOLIC SYNDROME
AB Introduction.
   One of the factors involved in type 2 diabetes in males is a reduction in levels of testosterone, which has been shown to predict resistance to insulin and the development of cardiovascular diseases.
   Aim.
   To assess the levels of testosterone in patients with type 2 diabetes and to evaluate their relationship with cardiovascular risk factors, peripheral arterial disease (PAD) and silent myocardial ischemia (SMI).
   Methods.
   Total testosterone and sex hormone binding globulin were measured and free and bioavailable testosterones were calculated using Vermeulen's formula. Levels of total testosterone >= 12 nmol/L or free testosterone > 225 pmol/L were considered normal. PAD was evaluated using the ankle-brachial index. SMI was assessed using a baseline ECG, Doppler echocardiogram, 24-hour electrocardiogram (ECG) Holter, exercise stress testing (EST), nuclear stress (if EST inconclusive), and if the result was positive, a coronary angiography.
   Main Outcome Measures.
   PAD, SMI, testosterone, erectile dysfunction, 24-hour blood pressure Holter, body mass index (BMI), waist circumference, lipid profile, insulin resistance, chronic inflammation, United Kingdom Prospective Diabetes Study cardiovascular risk score, nephropathy, retinopathy, and neuropathy.
   Results.
   The study population was composed of 192 diabetic males with a mean age of 56.1 +/- 7.8 years and without a history of vascular disease. Twenty-three percent presented total testosterone below normal and 21.8% presented low free testosterone. BMI, waist circumference, neuropathy, triglycerides, C-reactive protein (CRP), glucose, insulin, and HOMA-IR were found to be significantly incremented with respect to subjects with normal testosterone. There was a negative correlation of HOMA-IR with total testosterone. PAD was detected in 12% and SMI in 10.9% of subjects, and differences were not related to testosterone levels.
   Conclusions.
   We have verified the prevalence of low testosterone levels in male patients with type 2 diabetes and have related them to variations in BMI, waist circumference, neuropathy, triglycerides, CRP, glucose, insulin and HOMA-IR, but not with an increase of SMI or PAD.
C1 [Hernandez-Mijares, Antonio; Garcia-Malpartida, Katherine; Sola-Izquierdo, Eva; Rocha, Milagros; Manuel Victor, Victor] Dr Peset Univ Hosp, Dept Endocrinol, Valencia, Spain.
   [Hernandez-Mijares, Antonio; Sola-Izquierdo, Eva] Univ Valencia, Dept Med, Valencia, Spain.
   [Hernandez-Mijares, Antonio; Banuls, Celia] Spanish Minist Hlth, Carlos Hlth Inst 3, Res Grp CIBER Act Epidemiol & Publ Hlth CB 06 02, Valencia, Spain.
   [Garcia-Malpartida, Katherine; Rocha, Milagros; Manuel Victor, Victor] Hosp Univ Dr Peset Fdn, Valencia, Spain.
   [Jesus Gomez-Martinez, Manuel; Marmol, Rosario] Dr Peset Univ Hosp, Dept Cardiol, Valencia, Spain.
C3 University of Valencia
RP Hernández-Mijares, A (corresponding author), Hosp Univ Doctor Peset, Avda Gaspar Aguilar 90, Valencia 46017, Spain.
EM hernandez_antmij@gva.es
RI victor, victor/Q-4843-2019; Banuls, Celia/H-7359-2017; Hernandez
   Mijares, Antonio/D-3411-2011; Hernandez Mijares, Antonio/D-3411-2011;
   Rocha, Milagros/I-4987-2015
OI Banuls, Celia/0000-0001-8077-7642; Hernandez Mijares,
   Antonio/0000-0003-2197-0607; Hernandez Mijares,
   Antonio/0000-0003-4099-1905; VICTOR, VICTOR/0000-0002-3027-3945; Rocha,
   Milagros/0000-0003-2923-6546
FU Instituto Carlos III, Ministry of Science and Innovation, Spain [FISS
   04/2175, FIS 07/0091]; FIS [(CP07/00171, CA07/00366]
FX We would like to thank Dr. Jose Antonio Sananton for his help in
   recruiting the patients, Dr. Maria Morales Suarez-Varela for her help in
   developing the statistical method, and Nurse Isabel Soria Cuenca for her
   work in the extraction of the biological samples. This study has been
   partially sponsored by grant FISS 04/2175 and FIS 07/0091 from the
   Instituto Carlos III, Ministry of Science and Innovation, Spain. Dr. VM
   Victor and M Rocha are recipients of FIS contracts (CP07/00171 and
   CA07/00366, respectively).
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NR 50
TC 29
Z9 29
U1 0
U2 11
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1743-6095
EI 1743-6109
J9 J SEX MED
JI J. Sex. Med.
PD MAY
PY 2010
VL 7
IS 5
BP 1954
EP 1964
DI 10.1111/j.1743-6109.2010.01705.x
PG 11
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 587PI
UT WOS:000277004400030
PM 20214724
DA 2025-06-11
ER

PT J
AU Wu, CJ
   Cheng, PW
   Kung, MH
   Ho, CY
   Pan, JY
   Tseng, CJ
   Chen, HH
AF Wu, Chieh-Jen
   Cheng, Pei-Wen
   Kung, Ming-Hsiang
   Ho, Chiu-Yi
   Pan, Jun-Yen
   Tseng, Ching-Jiunn
   Chen, Hsin-Hung
TI Glut5 Knockdown in the Nucleus Tractus Solitarii Alleviates
   Fructose-Induced Hypertension in Rats
SO JOURNAL OF NUTRITION
LA English
DT Article
DE fructose; glucose transporter 5; hypertension; nucleus tractus
   solitarii; reactive oxygen species; metabolic syndrome; insulin
   resistance
ID SYMPATHETIC-NERVE ACTIVITY; ACTIVATED PROTEIN-KINASE; OXIDATIVE STRESS;
   NADPH OXIDASE; GLUCOSE-TRANSPORTER; INSULIN SENSITIVITY; METABOLIC
   SYNDROME; AMPK ACTIVATION; BLOOD-PRESSURE; HEALTH
AB Background Several studies have suggested mechanisms whereby excessive fructose intake increases blood pressure (BP). Glucose transporter 5 (GLUT5) is a fructose transporter expressed on enterocytes, and its involvement in the nucleus tractus solitarius (NTS)-modulated increase in BP following fructose intake remains unclear. Objectives Herein, we investigated whether NTS Glut5 knockdown (KD) can alleviate fructose-induced hypertension in rat models. Methods Male Wistar-Kyoto rats (6-8 weeks old; average weight: 230 g) were randomly assigned into 4 groups [control (Con), fructose (Fru), fructose + scrambled (Fru + S), and Fru + KD]. The Con group rats had ad libitum access to regular water, and the other 3 groups were provided 10% fructose water ad libitum for 4 weeks (2 weeks before lentiviral transfection in the Fru + S and Fru + KD groups). Glut5 short hairpin RNA was delivered into the NTS of rats using a lentivirus system. Fructose-induced hypertension was assessed via the tail-cuff technique, a noninvasive blood pressure measurement approach. GLUT5-associated and other insulin signaling pathways in the NTS of rats were assessed using immunofluorescence and immunoblotting analyses. We evaluated between-group differences using the Mann-Whitney U test or Kruskal-Wallis 1-way ANOVA. Results Compared with the Fru + S group, the Fru + KD group had reduced sympathetic nerve hyperactivity (48.8 +/- 3.2 bursts/min; P < 0.05), improved central insulin signaling, upregulated protein kinase B (AKT; 3.0-fold) and neuronal NO synthase (nNOS; 2.78-fold) expression, and lowered BP (17 +/- 1 mmHg, P < 0.05). Moreover, Glut5 KD restored signaling dependent on adenosine 5 '-monophosphate-activated protein kinase and reduced fructose-induced oxidative stress 2.0-fold, and thus decreased NAD(P)H oxidase in p67-phox 1.9-fold within the NTS. Conclusions Fructose-induced reactive oxygen species generates in the NTS of rats through GLUT5 and receptor for advanced glycation end products signaling, thus impairing the AKT-nNOS-NO signaling pathway and ultimately causing hypertension.
C1 [Wu, Chieh-Jen; Pan, Jun-Yen] Kaohsiung Vet Gen Hosp, Dept Surg, Div Cardiovasc Surg, Kaohsiung, Taiwan.
   [Wu, Chieh-Jen] Shu Zen Jr Coll Med & Management, Dept Optometry, Kaohsiung, Taiwan.
   [Cheng, Pei-Wen; Kung, Ming-Hsiang; Ho, Chiu-Yi; Tseng, Ching-Jiunn; Chen, Hsin-Hung] Kaohsiung Vet Gen Hosp, Dept Med Educ & Res, Kaohsiung, Taiwan.
   [Cheng, Pei-Wen; Ho, Chiu-Yi; Tseng, Ching-Jiunn] Natl Sun Yat Sen Univ, Inst Biomed Sci, Kaohsiung, Taiwan.
   [Tseng, Ching-Jiunn] China Med Univ, China Med Univ Hosp, Dept Med Res, Taichung, Taiwan.
C3 Kaohsiung Veterans General Hospital; Kaohsiung Veterans General
   Hospital; National Sun Yat Sen University; China Medical University
   Taiwan; China Medical University Hospital - Taiwan
RP Tseng, CJ; Chen, HH (corresponding author), Kaohsiung Vet Gen Hosp, Dept Med Educ & Res, Kaohsiung, Taiwan.; Tseng, CJ (corresponding author), Natl Sun Yat Sen Univ, Inst Biomed Sci, Kaohsiung, Taiwan.; Tseng, CJ (corresponding author), China Med Univ, China Med Univ Hosp, Dept Med Res, Taichung, Taiwan.
EM cjtseng@vghks.gov.tw; derekchen@vghks.gov.tw
RI ; Chen, Hsin-Hung/IAM-3877-2023
OI Tseng, Ching-Jiunn/0000-0001-5432-9897; Ho, Chiu-Yi/0000-0002-8081-3946;
   Chen, Hsin-Hung/0000-0002-5662-5945
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NR 56
TC 3
Z9 4
U1 0
U2 5
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0022-3166
EI 1541-6100
J9 J NUTR
JI J. Nutr.
PD FEB 8
PY 2022
VL 152
IS 2
BP 448
EP 457
DI 10.1093/jn/nxab374
EA NOV 2021
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA ZP3CY
UT WOS:000766302000011
PM 34687200
OA Bronze
DA 2025-06-11
ER

PT J
AU El-Magd, NAF
   El-Mesery, M
   El-Karef, A
   El-Shishtawy, MM
AF Abo El-Magd, Nada F.
   El-Mesery, Mohamed
   El-Karef, Amro
   El-Shishtawy, Mamdouh M.
TI Amelioration effect of black seed oil against high-fat diet-induced
   obesity in rats through Nrf2/HO-1 pathway
SO JOURNAL OF FOOD BIOCHEMISTRY
LA English
DT Article
DE black seed oil; heme oxygenase&#8208; 1; high&#8208; fat diet; nuclear
   factor erythroid&#8208; 2&#8208; related factor&#8208; 2; obesity
ID DENSITY-LIPOPROTEIN CHOLESTEROL; INDUCED METABOLIC SYNDROME;
   NIGELLA-SATIVA L.; BODY-MASS INDEX; OXIDATIVE STRESS; THYMOQUINONE;
   NRF2; ACTIVATION; MODEL; GLUCONEOGENESIS
AB Obesity is a chronic inflammatory disease that represents a risk factor for number of diseases including diabetes, steatohepatitis, and cancer. Using safe natural compounds to ameliorate obesity and its related metabolic syndrome is an interesting spot for research. We investigated the regulatory role and the underlying mechanism of black seed oil (BSO) on high-fat diet (HFD)-induced obesity in rats. The study included two models: the first one aimed to study the prophylactic effect of BSO (BSO administration for 10 weeks along with HFD) while the second one aimed to study the treatment role of BSO (BSO administration starting from the 10th week for 4 weeks along with HFD). BSO significantly decreased insulin resistance and body weight characteristics in both models. It also normalized lipid profile. Moreover, histopathological examination confirmed these results as BSO significantly decreased adipocyte size and hepatic lipid deposition. Besides, BSO alleviated HFD-induced oxidative stress as indicated by significant increase in the total antioxidant capacity and significant decrease in liver malondialdehyde. Moreover, BSO decreased significantly liver gluconeogenic enzymes mRNA expressions (phosphoenolpyruvate carboxykinase and glucose-6-phosphatase) and increased significantly heme oxygenase-1 (HO-1), nuclear factor erythroid-2-related factor-2 (Nrf2) and insulin receptor mRNA expressions. In conclusion, BSO represents a natural therapy that has the ability to prevent and treat HFD-induced obesity in rats that may be mediated through Nrf2/HO-1 pathway's activation and insulin receptor expression's increase. To our best knowledge, this study represents a novel study that investigates the regulatory role of BSO on Nrf2 pathway in preventing and treating HFD-induced obesity.
   Practical applications Black seed oil is a natural available safe supplement, thus it can be used for prevention from obesity and even treatment of obesity and obesity related complications. Introducing of black seed oil in the treatment regimen of obese patients may be promising.
C1 [Abo El-Magd, Nada F.; El-Mesery, Mohamed; El-Shishtawy, Mamdouh M.] Mansoura Univ, Dept Biochem, Fac Pharm, Mansoura, Egypt.
   [El-Karef, Amro] Mansoura Univ, Dept Pathol, Fac Med, Mansoura, Egypt.
C3 Egyptian Knowledge Bank (EKB); Mansoura University; Egyptian Knowledge
   Bank (EKB); Mansoura University
RP El-Magd, NAF; El-Shishtawy, MM (corresponding author), Mansoura Univ, Dept Biochem, Fac Pharm, Mansoura, Egypt.
EM nadafawzy@mans.edu.eg; mshisht@mans.edu.eg
RI El-Shishtawy, Mamdouh/O-6626-2018; El-Mesery, Mohamed/ADM-7145-2022; Abo
   El-Magd, Nada/O-5930-2018
OI Fawzy, Nada/0000-0003-2896-2802
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NR 65
TC 9
Z9 9
U1 0
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0145-8884
EI 1745-4514
J9 J FOOD BIOCHEM
JI J. Food Biochem.
PD APR
PY 2021
VL 45
IS 4
AR e13693
DI 10.1111/jfbc.13693
EA MAR 2021
PG 12
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA RS9FS
UT WOS:000628869100001
PM 33719073
OA gold
DA 2025-06-11
ER

PT J
AU Apovian, CM
   Aronne, L
   Rubino, D
   Still, C
   Wyatt, H
   Burns, C
   Kim, D
   Dunayevich, E
AF Apovian, Caroline M.
   Aronne, Louis
   Rubino, Domenica
   Still, Christopher
   Wyatt, Holly
   Burns, Colleen
   Kim, Dennis
   Dunayevich, Eduardo
CA COR-II Study Grp
TI A Randomized, Phase 3 Trial of Naltrexone SR/Bupropion SR on Weight and
   Obesity-related Risk Factors (COR-II)
SO OBESITY
LA English
DT Article
ID BLOOD-PRESSURE; OVERWEIGHT
AB Objective: To examine the effects of naltrexone/bupropion (NB) combination therapy on weight and weight-related risk factors in overweight and obese participants.
   Design and Methods: CONTRAVE Obesity Research-II (COR-II) was a double-blind, placebo-controlled study of 1,496 obese (BMI 30-45 kg/m(2)) or overweight (27-45 kg/m(2) with dyslipidemia and/or hypertension) participants randomized 2: 1 to combined naltrexone sustained-release (SR) (32 mg/day) plus bupropion SR (360 mg/day) (NB32) or placebo for up to 56 weeks. The co-primary endpoints were percent weight change and proportion achieving >= 5% weight loss at week 28.
   Results: Significantly (P < 0.001) greater weight loss was observed with NB32 versus placebo at week 28 (-6.5% vs. -1.9%) and week 56 (-6.4% vs. -1.2%). More NB32-treated participants (P < 0.001) experienced >= 5% weight loss versus placebo at week 28 (55.6% vs. 17.5%) and week 56 (50.5% vs. 17.1%). NB32 produced greater improvements in various cardiometabolic risk markers, participant-reported weight-related quality of life, and control of eating. The most common adverse event with NB was nausea, which was generally mild to moderate and transient. NB was not associated with increased events of depression or suicidality versus placebo.
   Conclusion: NB represents a novel pharmacological approach to the treatment of obesity, and may become a valuable new therapeutic option.
C1 [Apovian, Caroline M.] Boston Univ, Sch Med, Dept Med, Sect Endocrinol Diabet & Nutr, Boston, MA 02118 USA.
   [Aronne, Louis] Weill Cornell Med Coll, New York, NY USA.
   [Rubino, Domenica] Washington Ctr Weight Management, Arlington, VA USA.
   [Still, Christopher] Geisinger Hlth Care Syst, Danville, PA USA.
   [Wyatt, Holly] Univ Colorado, Denver, CO 80202 USA.
   [Burns, Colleen; Kim, Dennis; Dunayevich, Eduardo] Orexigen Therapeut Inc, La Jolla, CA USA.
C3 Boston University; Cornell University; Weill Cornell Medicine;
   University of Colorado System; University of Colorado Denver
RP Apovian, CM (corresponding author), Boston Univ, Sch Med, Dept Med, Sect Endocrinol Diabet & Nutr, Boston, MA 02118 USA.
EM Caroline.Apovian@BMC.org
RI Aronne, Louis/ABC-8865-2020
OI Rubino, Domenica/0000-0002-3072-2819; Apovian,
   Caroline/0000-0002-8029-1922
FU Lilly; Amylin; Pfizer; Sanofi-Aventis; Orexigen; MetaProteomics; Dr.
   Robert C. and Veronica Atkins Foundation; Ethicon Endo-Surgery Arena;
   Orexigen Pharmaceuticals; NIH; Novo Nordisk
FX C.M.A has participated on advisory boards for Allergan, Amylin,
   Orexigen, Merck, Johnson and Johnson, Abbott, Arena, Zafgen, Novo
   Nordisk, and Sanofi-Aventis, and has received research funding from
   Lilly, Amylin, Pfizer, Sanofi-Aventis, Orexigen, MetaProteomics, and the
   Dr. Robert C. and Veronica Atkins Foundation. L.J.A. has participated in
   advisory boards/acted as a consultant for Amylin Pharmaceuticals, Inc.,
   Ethicon Endo-Surgery, Inc., GlaxoSmithKline Consumer Healthcare LP, Novo
   Nordisk, Orexigen Therapeutics, Inc., VIVUS, Inc., Takeda
   Pharmaceuticals, and Zafgen, Inc. L.J.A has also performed contracted
   research for Amylin Pharmaceuticals, Inc., High Point Pharmaceuticals
   LLC, Medical University of South Carolina (MUSC), and Novo Nordisk, and
   has ownership interest in Cardiometabolic Support Network, LLC, and Myos
   Corporation.C.D.S. has participated on advisory boards for Allergan, and
   Ethicon-Endosurgery. C.D.S. has also received research funding from
   Ethicon Endo-Surgery Arena and Orexigen Pharmaceuticals.H.W. received
   has served as an advisor for Orexigen Pharmaceuticals, Arena
   Pharmaceuticals, Wellspring Camps, and Eisai, Inc. H.W. receives
   royalties from Up to Date and has received grant funding from the NIH,
   Orexigen, and Novo Nordisk. H.W. has ownership interests in Active
   Planet LLC and has co-ownership on a patent for a weight loss
   maintenance strategy.
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   2012, PRESCRIBING INFORMAT, P1
NR 26
TC 424
Z9 446
U1 0
U2 43
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1930-7381
EI 1930-739X
J9 OBESITY
JI Obesity
PD MAY
PY 2013
VL 21
IS 5
BP 935
EP 943
DI 10.1002/oby.20309
PG 9
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 187AR
UT WOS:000322088300011
PM 23408728
OA Green Published
DA 2025-06-11
ER

PT J
AU Buckwalter, JG
   Castellani, B
   McEwen, B
   Karlamangla, AS
   Rizzo, AA
   John, B
   O'Donnell, K
   Seeman, T
AF Buckwalter, J. Galen
   Castellani, Brian
   McEwen, Bruce
   Karlamangla, Arun S.
   Rizzo, Albert A.
   John, Bruce
   O'Donnell, Kyle
   Seeman, Teresa
TI Allostatic Load as a Complex Clinical Construct: A Case-Based
   Computational Modeling Approach
SO COMPLEXITY
LA English
DT Article
DE allostatic load; health risk outcomes; complexity theory; artificial
   neural nets; computational modeling; case-based modeling
ID CUMULATIVE BIOLOGICAL RISK; DEHYDROEPIANDROSTERONE-SULFATE;
   MARKET-SEGMENTATION; HEALTH DISPARITIES; HORMONE LEVELS; ELDERLY-MEN;
   K-MEANS; STRESS; WOMEN; MORTALITY
AB Allostatic load (AL) is a complex clinical construct, providing a unique window into the cumulative impact of stress. However, due to its inherent complexity, AL presents two major measurement challenges to conventional statistical modeling (the field's dominant methodology): it is comprised of a complex causal network of bioallostatic systems, represented by an even larger set of dynamic biomarkers; and, it is situated within a web of antecedent socioecological systems, linking AL to differences in health outcomes and disparities. To address these challenges, we employed case-based computational modeling (CBM), which allowed us to make four advances: (1) we developed a multisystem, 7-factor (20 biomarker) model of AL's network of allostatic systems; (2) used it to create a catalog of nine different clinical AL profiles (causal pathways); (3) linked each clinical profile to a typology of 23 health outcomes; and (4) explored our results (post hoc) as a function of gender, a key socioecological factor. In terms of highlights, (a) the Healthy clinical profile had few health risks; (b) the pro-inflammatory profile linked to high blood pressure and diabetes; (c) Low Stress Hormones linked to heart disease, TIA/Stroke, diabetes, and circulation problems; and (d) high stress hormones linked to heart disease and high blood pressure. Post hoc analyses also found that males were overrepresented on the High Blood Pressure (61.2%), Metabolic Syndrome (63.2%), High Stress Hormones (66.4%), and High Blood Sugar (57.1%); while females were overrepresented on the Healthy (81.9%), Low Stress Hormones (66.3%), and Low Stress Antagonists (stress buffers) (95.4%) profiles. (C) 2015 Wiley Periodicals, Inc.
C1 [Buckwalter, J. Galen; Rizzo, Albert A.; John, Bruce; O'Donnell, Kyle] Univ Southern Calif, Inst Creat Technol, Los Angeles, CA 90094 USA.
   [Castellani, Brian] Kent State Univ, Dept Sociol, Kent, OH 44240 USA.
   [McEwen, Bruce] Rockefeller Univ, Neuroendocrinol Lab, New York, NY 10065 USA.
   [Karlamangla, Arun S.; Seeman, Teresa] Univ Calif Los Angeles, David Geffen Sch Med, Div Geriatr, Los Angeles, CA 90095 USA.
C3 University of Southern California; University System of Ohio; Kent State
   University; Kent State University Kent; Kent State University Salem;
   Rockefeller University; University of California System; University of
   California Los Angeles; University of California Los Angeles Medical
   Center; David Geffen School of Medicine at UCLA
RP Buckwalter, JG (corresponding author), Univ Southern Calif, Inst Creat Technol, Los Angeles, CA 90094 USA.
EM g_buckwalter@yahoo.com
RI McEwen, Bruce/Z-1630-2019
OI Buckwalter, J. Galen/0000-0001-9110-0039; Castellani,
   Brian/0000-0002-8763-8052
FU Stress Resilience In Virtual Environments Involving Loss and Grief
   (STRIVE-Loss) [W911NF-04-D-0005]; STRIVE-ONR Project: Stress Resistance
   in Virtual Environments for ONR [N00014-12-1-0163]; National Institutes
   of Health [P01-AG-020166, M01-RR000865]; ESRC [ES/L00092X/1] Funding
   Source: UKRI
FX Grants: Stress Resilience In Virtual Environments Involving Loss and
   Grief (STRIVE-Loss) W911NF-04-D-0005. The STRIVE-ONR Project: Stress
   Resistance in Virtual Environments for ONR N00014-12-1-0163. The authors
   would like to acknowledge following grants National Institutes of Health
   grants P01-AG-020166 and M01-RR000865.
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NR 55
TC 26
Z9 36
U1 0
U2 18
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1076-2787
EI 1099-0526
J9 COMPLEXITY
JI Complexity
PD SEP-OCT
PY 2016
VL 21
IS S1
BP 291
EP 306
DI 10.1002/cplx.21743
PG 16
WC Mathematics, Interdisciplinary Applications; Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Mathematics; Science & Technology - Other Topics
GA EC7PK
UT WOS:000388332600022
PM 28190951
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Gebreab, SY
   Diez-Roux, AV
   Hickson, DA
   Boykin, S
   Sims, M
   Sarpong, DF
   Taylor, HA
   Wyatt, SB
AF Gebreab, Samson Y.
   Diez-Roux, Ana V.
   Hickson, DeMarc A.
   Boykin, Shawn
   Sims, Mario
   Sarpong, Daniel F.
   Taylor, Herman A.
   Wyatt, Sharon B.
TI The contribution of stress to the social patterning of clinical and
   subclinical CVD risk factors in African Americans: The Jackson Heart
   Study
SO SOCIAL SCIENCE & MEDICINE
LA English
DT Article
DE USA; Stress; Social patterning; Cardiovascular disease; Risk factors;
   Mediation analysis; African Americans
ID INTIMA-MEDIA THICKNESS; EARLY-LIFE STRESS; SOCIOECONOMIC-STATUS;
   PSYCHOSOCIAL FACTORS; CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME;
   PHYSICAL-ACTIVITY; BLOOD-PRESSURE; JOB STRESS; HEALTH
AB It is often hypothesized that psychosocial stress may contribute to associations of socioeconomic position (SEP) with risk factors for cardiovascular disease (CVD). However, few studies have investigated this hypothesis among African Americans, who may be more frequently exposed to stressors due to social and economic circumstances. Cross-sectional data from the Jackson Heart Study (JHS), a large population-based cohort of African Americans, were used to examine the contributions of stressors to the association of SEP with selected cardiovascular (CVD) risk factors and subclinical atherosclerotic disease. Among women, higher income was associated with lower prevalence of hypertension, obesity, diabetes and carotid plaque and lower levels of stress. Higher stress levels were also weakly, albeit positively, associated with hypertension, diabetes, and obesity, but not with plaque. Adjustment for the stress measures reduced the associations of income with hypertension, diabetes and obesity by a small amount that was comparable to, or larger, than the reduction observed after adjustment for behavioral risk factors. In men, high income was associated with lower prevalence of diabetes and stressors were not consistently associated with any of the outcomes examined. Overall, modest mediation effects of stressors were observed for diabetes (15.9%), hypertension (9.7%), and obesity (5.1%) among women but only results for diabetes were statistically significant. No mediation effects of stressors were observed in men. Our results suggest that stressors may partially contribute to associations of SEP with diabetes and possibly hypertension and obesity in African American women. Further research with appropriate study designs and data is needed to understand the dynamic and interacting effects of stressors and behaviors on CVD outcomes as well as sex differences in these effects. (C) 2012 Elsevier Ltd. All rights reserved.
C1 [Gebreab, Samson Y.] Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA.
   [Hickson, DeMarc A.; Taylor, Herman A.] Jackson State Univ, Jackson Heart Study, Jackson, MS USA.
   [Hickson, DeMarc A.; Sims, Mario; Taylor, Herman A.] Univ Mississippi, Med Ctr, Sch Med, Jackson, MS 39216 USA.
   [Sarpong, Daniel F.] Jackson State Univ, Sch Hlth Sci, Jackson, MS USA.
   [Wyatt, Sharon B.] Univ Mississippi, Med Ctr, Sch Nursing, Jackson, MS 39216 USA.
C3 University of Michigan System; University of Michigan; Jackson State
   University; University of Mississippi Medical Center; University of
   Mississippi Medical Center; University of Mississippi; Jackson State
   University; University of Mississippi; University of Mississippi Medical
   Center
RP Gebreab, SY (corresponding author), Univ Michigan, Sch Publ Hlth, Dept Epidemiol, 1415 Washington Hts, Ann Arbor, MI 48109 USA.
EM samsong@umich.edu
FU Michigan Center for Integrative Approaches to Health Disparities
   [P60MD002249]; National Center on Minority Health and Health
   Disparities; National Heart, Lung, and Blood Institute, NIH
   [N01-HC-95170, N01-HC-95171, N01-HC-95172]
FX This research was supported by the Michigan Center for Integrative
   Approaches to Health Disparities (P60MD002249) funded by the National
   Center on Minority Health and Health Disparities. The Jackson Heart
   Study is supported by NIH contracts N01-HC-95170, N01-HC-95171, and
   N01-HC-95172 that were provided by the National Heart, Lung, and Blood
   Institute and the National Center for Minority Health and Health
   Disparities. We are grateful to Ermeg Akylbekova, Thomas Payneand Thomas
   Mosley for their helpful comments on an earlier draft of this
   manuscript. The authors would like to thank to the Jackson Heart Study
   participants, investigators, and staff for their valuable contributions
   to the study. S.Y. Gebreab conducted all statistical analyses and
   contributed to interpretation, writing, and revising the manuscript
   critically. A.V. Diez Roux contributed to the conceptualization, design
   of study, interpretation, writing, and revising the manuscript
   critically. D.A. Hickson contributed to interpretation and writing
   sections of the manuscript. S. Boykin contributed to design of study and
   drafting an earlier version of the manuscript. The remaining authors all
   equally contributed to reviewing drafts of the manuscript.
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NR 85
TC 56
Z9 73
U1 0
U2 26
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0277-9536
EI 1873-5347
J9 SOC SCI MED
JI Soc. Sci. Med.
PD NOV
PY 2012
VL 75
IS 9
BP 1697
EP 1707
DI 10.1016/j.socscimed.2012.06.003
PG 11
WC Public, Environmental & Occupational Health; Social Sciences, Biomedical
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; Biomedical Social Sciences
GA 013IS
UT WOS:000309299700019
PM 22841454
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Sáez, PJ
   Villalobos-Labra, R
   Westermeier, F
   Sobrevia, L
   Farías-Jofré, M
AF Saez, Pablo J.
   Villalobos-Labra, Roberto
   Westermeier, Francisco
   Sobrevia, Luis
   Farias-Jofre, Marcelo
TI Modulation of endothelial cell migration by ER stress and insulin
   resistance: a role during maternal obesity?
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Review
DE mesenchymal migration; unfolded protein response; RhoA; Akt; Scrib;
   polarization; cytoskeleton
ID ENDOPLASMIC-RETICULUM STRESS; UNFOLDED PROTEIN RESPONSE; GESTATIONAL
   DIABETES-MELLITUS; SLC29A1 PROMOTER ACTIVITY; NITRIC-OXIDE SYNTHASE;
   METABOLIC SYNDROME; GROWTH-FACTOR; RHO GTPASES; IN-VITRO; ANGIOGENESIS
AB Adverse microenvironmental stimuli can trigger the endoplasmic reticulum (ER) stress pathway, which initiates the unfolded protein response (UPR), to restore protein-folding homeostasis. Several studies show induction of ER stress during obesity. Chronic UPR has been linked to different mechanisms of disease in obese and diabetic individuals, including insulin resistance (IR) and impaired angiogenesis. Endothelial cell (EC) migration is an initial step for angiogenesis, which is associated with remodeling of existing blood vessels. EC migration occurs according to the leader follower model, involving coordinated processes of chemotaxis, haptotaxis, and mechanotaxis.Thus, a fine-tuning of EC migration is necessary to provide the right timing to form the required vessels during angiogenesis. ER stress modulates EC migration at different levels, usually impairing migration and angiogenesis, although different effects may be observed depending on the tissue and/or microenvironment. In the context of pregnancy, maternal obesity (MO) induces IR in the offspring. Interestingly, several proteins associated with obesity-induced IR are also involved in EC migration, providing a potential link with the ER stress-dependent alterations observed in obese individuals. Different signaling cascades that converge on cytoskeleton regulation directly impact EC migration, including the Akt and/or RhoA pathways. In addition, ER is the main intracellular reservoir for Ca2+, which plays a pivotal role during EC migration. Therefore, ER stress-related alterations in Ca2+ signaling or Ca2+ levels might also produce distorted EC migration. However, the above findings have been studied in the context of adult obesity, and no information has been reported regarding the effect of MO on fetal EC migration. Here we summarize the state of knowledge about the possible mechanisms by which ER stress and IR might impact EC migration and angiogenesis in fetal endothelium exposed to MO during pregnancy.
C1 [Saez, Pablo J.; Villalobos-Labra, Roberto; Westermeier, Francisco; Sobrevia, Luis; Farias-Jofre, Marcelo] Pontificia Univ Catolica Chile, Cellular & Mol Physiol Lab, Div Obstet & Gynecol, Sch Med,Fac Med, Santiago 8330024, Chile.
   [Westermeier, Francisco] Univ San Sebastian, Fac Ciencia, Santiago, Chile.
   [Westermeier, Francisco] Univ Chile, Fac Chem & Pharmaceut Sci, Adv Ctr Chron Dis, Santiago, Chile.
   [Westermeier, Francisco] Univ Chile, Fac Med, Santiago 7, Chile.
   [Sobrevia, Luis] Univ Queensland, Clin Res Ctr, Fac Med & Biomed Sci, Herston, Qld, Australia.
   [Sobrevia, Luis] Univ Seville, Fac Pharm, Seville, Spain.
C3 Pontificia Universidad Catolica de Chile; Universidad San Sebastian;
   Universidad de Chile; Universidad de Chile; University of Queensland;
   University of Sevilla
RP Farías-Jofré, M (corresponding author), Pontificia Univ Catolica Chile, Cellular & Mol Physiol Lab, Div Obstet & Gynecol, Sch Med,Fac Med, Marcoleta 391,POB 114-D, Santiago 8330024, Chile.
EM mfarias@med.puc.cl
RI Sobrevia, Luis/H-9608-2016; Sáez, Pablo/AAB-4458-2019; Westermeier,
   Francisco/AAL-4145-2021; Farias, Marcelo/R-6063-2019; farias jofre,
   marcelo/C-5260-2011
OI farias jofre, marcelo/0000-0003-0473-2295; Sobrevia,
   Luis/0000-0001-5802-2243; Saez, Pablo J./0000-0003-0521-9426;
   Westermeier, Francisco/0000-0002-4476-4198; Villalobos-Labra,
   Roberto/0000-0002-9638-9721
FU Fondo Nacional de Desarrollo Cientifico y Tecnologico FONDECYT [1121145,
   1130801, 1110977, 11100192, 3130583, 3140532]; Programa de Investigacion
   Interdisciplinario (PIA) from Comision Nacional de Investigacion en
   Ciencia y Tecnologia, CONICYT Anillos [ACT-73]; International NETWORK
   program from CONICYT [130102]
FX Authors thank members of the Cellular and Molecular Physiology
   Laboratory (CMPL) in the Division of Obstetrics and Gynecology, Faculty
   of Medicine, Pontificia Universidad Catolica de Chile, for excellent
   secretarial and technical assistance, and the personnel of the Maternity
   Ward at Hospital Clinic of Pontificia Universidad Catolica de Chile.
   This study was funded by Fondo Nacional de Desarrollo Cientifico y
   Tecnologico FONDECYT grants 1121145, 1130801, 1110977, 11100192,
   3130583, 3140532; Programa de Investigacion Interdisciplinario (PIA)
   from Comision Nacional de Investigacion en Ciencia y Tecnologia, CONICYT
   Anillos ACT-73; and the International NETWORK program from CONICYT
   (130102).
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NR 113
TC 13
Z9 15
U1 0
U2 13
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD AUG 19
PY 2014
VL 5
AR 189
DI 10.3389/fphar.2014.00189
PG 10
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA AX7PW
UT WOS:000347108400002
PM 25191269
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Harris, ML
   Oldmeadow, C
   Hure, A
   Luu, J
   Loxton, D
   Attia, J
AF Harris, Melissa L.
   Oldmeadow, Christopher
   Hure, Alexis
   Luu, Judy
   Loxton, Deborah
   Attia, John
TI Stress increases the risk of type 2 diabetes onset in women: A 12-year
   longitudinal study using causal modelling
SO PLOS ONE
LA English
DT Article
ID PERCEIVED STRESS; PSYCHOSOCIAL FACTORS; METABOLIC SYNDROME; MELLITUS;
   EXERCISE; JAPANESE; OBESITY; HEALTH; TRIALS
AB Background Type 2 diabetes is associated with significant morbidity and mortality. Modifiable risk factors have been found to contribute up to 60% of type 2 diabetes risk. However, type 2 diabetes continues to rise despite implementation of interventions based on traditional risk factors. There is a clear need to identify additional risk factors for chronic disease prevention. The aim of this study was to examine the relationship between perceived stress and type 2 diabetes onset, and partition the estimates into direct and indirect effects.
   Methods and findings Women born in 1946 -1951 (n = 12,844) completed surveys for the Australian Longitudinal Study on Women's Health in 1998, 2001, 2004, 2007 and 2010. The total causal effect was estimated using logistic regression and marginal structural modelling. Controlled direct effects were estimated through conditioning in the regression model. A graded association was found between perceived stress and all mediators in the multivariate time lag analyses. A significant association was found between hypertension, as well as physical activity and body mass index, and diabetes, but not smoking or diet quality. Moderate/high stress levels were associated with a 2.3-fold increase in the odds of diabetes three years later, for the total estimated effect. Results were only slightly attenuated when the direct and indirect effects of perceived stress on diabetes were partitioned, with the mediators only explaining 10-20% of the excess variation in diabetes.
   Conclusions Perceived stress is a strong risk factor for type 2 diabetes. The majority of the effect estimate of stress on diabetes risk is not mediated by the traditional risk factors of hypertension,physical activity, smoking, diet quality, and body mass index. This gives a new pathway for diabetes prevention trials and clinical practice.
C1 [Harris, Melissa L.; Hure, Alexis; Loxton, Deborah] Univ Newcastle, Fac Hlth & Med, Res Ctr Generat Hlth & Ageing, Newcastle, NSW, Australia.
   [Oldmeadow, Christopher; Attia, John] Hunter Med Res Inst, Clin Res Design IT & Stat Support Unit, Newcastle, NSW, Australia.
   [Oldmeadow, Christopher; Hure, Alexis; Luu, Judy; Attia, John] Univ Newcastle, Sch Med & Publ Hlth, Fac Hlth & Med, Newcastle, NSW, Australia.
   [Luu, Judy; Attia, John] Hunter New England Hlth, John Hunter Hosp, Div Med, Newcastle, NSW, Australia.
C3 University of Newcastle; Hunter Medical Research Institute; University
   of Newcastle; University of Newcastle; John Hunter Hospital
RP Hure, A (corresponding author), Univ Newcastle, Fac Hlth & Med, Res Ctr Generat Hlth & Ageing, Newcastle, NSW, Australia.; Hure, A (corresponding author), Univ Newcastle, Sch Med & Publ Hlth, Fac Hlth & Med, Newcastle, NSW, Australia.
EM Alexis.Hure@newcastle.edu.au
RI Hure, Alexis/D-6790-2011; Oldmeadow, Chris/HKF-3685-2023; Attia,
   John/F-5376-2013
OI Attia, John/0000-0001-9800-1308; Oldmeadow,
   Christopher/0000-0001-6104-1322; Hure, Alexis/0000-0003-2225-0986;
   Harris, Melissa/0000-0002-5733-9684
FU Australian Government Department of Health; John Hunter Hospital
   Charitable Trust
FX This work uses data from the Australian Longitudinal Study on Women's
   Health, which is funded by the Australian Government Department of
   Health. This analysis was funded by a John Hunter Hospital Charitable
   Trust Grant received by MLH, JL, DL, and JA. The funders had no role in
   study design, data collection and analysis, decision to publish, or
   preparation of the manuscript.
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NR 37
TC 71
Z9 80
U1 0
U2 10
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD FEB 21
PY 2017
VL 12
IS 2
AR e172126
DI 10.1371/journal.pone.0172126
PG 13
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Science & Technology - Other Topics
GA EL5QV
UT WOS:000394676800032
PM 28222165
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Giudetti, AM
   Vergara, D
   Longo, S
   Friuli, M
   Eramo, B
   Tacconi, S
   Fidaleo, M
   Dini, L
   Romano, A
   Gaetani, S
AF Giudetti, Anna Maria
   Vergara, Daniele
   Longo, Serena
   Friuli, Marzia
   Eramo, Barbara
   Tacconi, Stefano
   Fidaleo, Marco
   Dini, Luciana
   Romano, Adele
   Gaetani, Silvana
TI Oleoylethanolamide Reduces Hepatic Oxidative Stress and Endoplasmic
   Reticulum Stress in High-Fat Diet-Fed Rats
SO ANTIOXIDANTS
LA English
DT Article
DE oleoylethanolamide; nuclear factor erythroid-derived 2-related factor 1
   (Nrf1); nuclear factor erythroid-derived 2-related factor 2 (Nrf2);
   oxidative stress; diet-induced obesity; non-alcoholic fatty liver
ID TRANSCRIPTION FACTOR; LIVER-DISEASE; METABOLIC SYNDROME;
   GENE-EXPRESSION; FOOD-INTAKE; NRF1; DELETION; LIPOGENESIS; MICE;
   STEATOHEPATITIS
AB Long-term high-fat diet (HFD) consumption can cause weight gain and obesity, two conditions often associated with hepatic non-alcoholic fatty liver and oxidative stress. Oleoylethanolamide (OEA), a lipid compound produced by the intestine from oleic acid, has been associated with different beneficial effects in diet-induced obesity and hepatic steatosis. However, the role of OEA on hepatic oxidative stress has not been fully elucidated. In this study, we used a model of diet-induced obesity to study the possible antioxidant effect of OEA in the liver. In this model rats with free access to an HFD for 77 days developed obesity, steatosis, and hepatic oxidative stress, as compared to rats consuming a low-fat diet for the same period. Several parameters associated with oxidative stress were then measured after two weeks of OEA administration to diet-induced obese rats. We showed that OEA reduced, compared to HFD-fed rats, obesity, steatosis, and the plasma level of triacylglycerols and transaminases. Moreover, OEA decreased the amount of malondialdehyde and carbonylated proteins and restored the activity of antioxidant enzymes superoxide dismutase, catalase, and glutathione peroxidase, which decreased in the liver of HFD-fed rats. OEA had also an improving effect on parameters linked to endoplasmic reticulum stress, thus demonstrating a role in the homeostatic control of protein folding. Finally, we reported that OEA differently regulated the expression of two transcription factors involved in the control of lipid metabolism and antioxidant genes, namely nuclear factor erythroid-derived 2-related factor 1 (Nrf1) and Nrf2, thus suggesting, for the first time, new targets of the protective effect of OEA in the liver.
C1 [Giudetti, Anna Maria; Vergara, Daniele; Longo, Serena; Tacconi, Stefano] Univ Salento, Dept Biol & Environm Sci & Technol, Via Provle Lecce Monteroni, I-73100 Lecce, Italy.
   [Friuli, Marzia; Eramo, Barbara; Romano, Adele; Gaetani, Silvana] Sapienza Univ Rome, Dept Physiol & Pharmacol V Erspamer, Ple Aldo Moro 5, I-00185 Rome, Italy.
   [Fidaleo, Marco; Dini, Luciana] Sapienza Univ Rome, Dept Biol & Biotechnol C Darwin, Ple Aldo Moro 5, I-00185 Rome, Italy.
   [Fidaleo, Marco; Dini, Luciana] Sapienza Univ Rome, Res Ctr Nanotechnol Engn Sapienza CNIS, Ple Aldo Moro 5, I-00185 Rome, Italy.
C3 University of Salento; Sapienza University Rome; Sapienza University
   Rome; Sapienza University Rome
RP Giudetti, AM (corresponding author), Univ Salento, Dept Biol & Environm Sci & Technol, Via Provle Lecce Monteroni, I-73100 Lecce, Italy.; Gaetani, S (corresponding author), Sapienza Univ Rome, Dept Physiol & Pharmacol V Erspamer, Ple Aldo Moro 5, I-00185 Rome, Italy.
EM anna.giudetti@unisalento.it; daniele.vergara@unisalento.it;
   serena.longo@unisalento.it; marzia.friuli@uniroma1.it;
   barbara.eramo@uniroma1.it; stefano.tacconi@unisalento.it;
   marcolidaleo@uniroma1.it; luciana.dini@uniroma1.it;
   adele.romano@uniroma1.it; silvana.gaetani@uniroma1.it
RI Tacconi, Stefano/JFJ-4278-2023; Longo, Serena/AHI-0456-2022; Giudetti,
   Anna/ABF-4049-2021; Fidaleo, Marco/K-1671-2016; Vergara,
   Daniele/K-3831-2014
OI LONGO, SERENA/0000-0001-8595-1259; GIUDETTI, ANNA
   MARIA/0000-0002-9204-040X; Fidaleo, Marco/0000-0002-1287-9601; Dini,
   Luciana/0000-0002-2633-9040; Eramo, Barbara/0000-0001-9178-8515; Friuli,
   Marzia/0000-0001-7481-3424; Vergara, Daniele/0000-0002-2396-7674;
   ROMANO, ADELE/0000-0003-3874-2627; Tacconi, Stefano/0000-0001-7424-1251
FU Italian Ministry of Education, University and Research [PRIN
   2017XZMBYX_004]
FX This research was supported by grants (PRIN 2017XZMBYX_004 to S.G.) of
   the Italian Ministry of Education, University and Research.
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NR 72
TC 25
Z9 26
U1 1
U2 18
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD AUG
PY 2021
VL 10
IS 8
AR 1289
DI 10.3390/antiox10081289
PG 17
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA UF5IK
UT WOS:000688607500001
PM 34439537
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Li, L
   Li, G
   Wei, H
   Chen, J
   Sun, J
   Chen, Y
   Xie, B
   Wang, B
   Li, C
   Tian, B
   Wang, F
AF Li, L.
   Li, G.
   Wei, H.
   Chen, J.
   Sun, J.
   Chen, Y.
   Xie, B.
   Wang, B.
   Li, C.
   Tian, B.
   Wang, F.
TI The endoplasmic reticulum stress response is associated with insulin
   resistance-mediated drug resistance in HepG2 cells
SO NEOPLASMA
LA English
DT Article
DE insulin resistance; drug resistance; P-gp; endoplasmic reticulum stress;
   HepG2 cells
ID P-GLYCOPROTEIN; MULTIDRUG-RESISTANCE; MOLECULAR-MECHANISM; METABOLIC
   SYNDROME; DIABETES-MELLITUS; INDUCED APOPTOSIS; CANCER-RISK; ER STRESS;
   EXPRESSION; PROTEIN
AB Insulin resistance has a close relationship with tumorigenesis, tumor progression, and cancer prognosis. Importantly, the liver is the main target tissue of insulin, and the resistance to chemotherapeutic agents has been reported in hepato-carcinoma. However, little is known about the relationship between drug resistance and insulin resistance in hepatocarcinoma. Therefore, we treated HepG2 cells (a human hepatoma cell line) with high concentrations of insulin to establish a cell-based model of insulin resistance (HepG2/IR cells) to define the relationship between insulin resistance and the resistance to chemotherapy. We identified that HepG2/IR cells exhibited stable insulin resistance, with decreased glucose consumption, reduced glycogen synthesis, and decreased expression of the insulin receptor gene. HepG2/IR cells also exhibited endoplasmic reticulum (ER) dilatation and degranulation. Molecular markers of endoplasmic reticulum stress, including glucose-regulated protein78 (GRP78) and phosphorylated protein kinase R-like ER kinase (p-PERK), increased significantly, which was accompanied by increased reactive oxygen metabolism and decreased mitochondrial membrane potential. In addition, HepG2/IR cells were resistant to the chemotherapy agent Adriamycin, which was accompanied by the upregulation of multidrug resistance gene 1/ P-glycoprotein (P-gp; an endoplasmic reticulum chaperone that plays a role in ER stress), and enhanced drug efflux. These data suggest that the endoplasmic reticulum (ER) stress response was active in HepG2/IR cells, and that insulin resistance was related to drug resistance in HepG2 cells. Interestingly, the ER stress and chemotherapy resistance observed in HepG2/IR cells could be reversed by treatment with the insulin sensitizer pioglitazone. Therefore, our study suggests that there is a close relationship between the resistance to chemotherapy and insulin resistance in HepG2 cells, and that the ER stress response play a role in insulin resistance-mediated drug resistance in hepatocarcinoma cells.
C1 [Li, L.; Wei, H.; Chen, J.; Sun, J.; Chen, Y.; Xie, B.; Wang, B.; Li, C.; Tian, B.; Wang, F.] Lanzhou Univ, Sch Basic Med Sci, Key Lab Preclin Study New Drugs Gansu Prov, Lanzhou 730000, Gansu, Peoples R China.
   [Li, L.; Li, G.] Lanzhou Univ, Hosiptal 2, Dept Clin Lab, Lanzhou 730000, Gansu, Peoples R China.
C3 Lanzhou University; Lanzhou University
RP Wei, H (corresponding author), Lanzhou Univ, Sch Basic Med Sci, Key Lab Preclin Study New Drugs Gansu Prov, 199 Donggang West Rd, Lanzhou 730000, Gansu, Peoples R China.
EM weihulai@lzu.edu.cn
FU Fundamental Research Funds for the Central Universities
   [lzujbky-2013142]; project of youth science and technology fund of Gansu
   province of China [1308RJYA05]; Program for Changjiang Scholars and
   Innovative Research Team in University (PCSIRT) [IRT1137]
FX This work was supported by the Fundamental Research Funds for the
   Central Universities(Grant No: lzujbky-2013142), the project of youth
   science and technology fund of Gansu province of China(Grant No:
   1308RJYA05) and the Program for Changjiang Scholars and Innovative
   Research Team in University (PCSIRT No: IRT1137)
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NR 52
TC 11
Z9 12
U1 2
U2 58
PU AEPRESS SRO
PI BRATISLAVA
PA BAJZOVA 7, BRATISLAVA, 821 08, SLOVAKIA
SN 0028-2685
EI 1338-4317
J9 NEOPLASMA
JI Neoplasma
PY 2015
VL 62
IS 2
BP 180
EP 190
DI 10.4149/neo_2015_023
PG 11
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA CT5PL
UT WOS:000362862400003
PM 25738311
OA Bronze
DA 2025-06-11
ER

PT J
AU Dennis, BA
   Ergul, A
   Gower, BA
   Allison, JD
   Davis, CL
AF Dennis, B. Adam
   Ergul, Adviye
   Gower, Barbara A.
   Allison, Jerry D.
   Davis, Catherine L.
TI Oxidative Stress and Cardiovascular Risk in Overweight Children in an
   Exercise Intervention Program
SO CHILDHOOD OBESITY
LA English
DT Article
ID SHORT-TERM DIET; INSULIN-RESISTANCE; METABOLIC SYNDROME; ADIPOSE-TISSUE;
   OBESE CHILDREN; DIABETES RISK; INFLAMMATION; YOUTH; ISOPROSTANES;
   PREVENTION
AB Background: This study aimed to determine whether oxidative stress was related to cardiovascular risk indices in children, and whether an exercise intervention would reduce oxidative stress.
   Methods: A randomized trial of two different doses of exercise and a no-exercise control group included 112 overweight and obese children, 7-11 years old. Plasma isoprostane levels were obtained at baseline and after the intervention. Cross-sectional analysis of oxidative stress and metabolic markers at baseline was performed. The effect of the exercise training on oxidative stress was tested.
   Results: Lower isoprostane levels were observed in blacks. At baseline, isoprostane was positively related to measures of fatness (BMI, waist circumference, percent body fat), insulin resistance and beta-cell function (fasting insulin, insulin area under the curve, Matsuda index, disposition index, oral disposition index), and several lipid markers (low-density lipoprotein, triglycerides, total cholesterol), and inversely with fitness [peak oxygen consumption (VO2)], independent of race, sex, and cohort. No relation was found with visceral fat, blood pressure, or glycemia. Independent of percent body fat, isoprostane predicted triglycerides, beta = 0.23, total cholesterol-to-high-density lipoprotein (TC/HDL) ratio, beta = 0.23, and insulin resistance (insulin area under the curve, beta = 0.24, Matsuda index, beta = -0.21, oral disposition index, beta = 0.33). Exercise did not reduce oxidative stress levels, despite reduced fatness and improved fitness in these children.
   Conclusions: Isoprostane levels were related to several markers of cardiovascular risk at baseline; however, despite reduced fatness and improved fitness, no effect of exercise was observed on isoprostane levels. To our knowledge, this is the first report in children to demonstrate a correlation of oxidative stress with disposition index, fitness, and TC/HDL ratio, the first to test the effect on oxidative stress of an exercise intervention that reduced body fat, and the first such exercise intervention study to include a substantial proportion of black children.
C1 [Dennis, B. Adam] Med Coll Georgia, Sect Endocrinol Diabet & Metab, Dept Med, Augusta, GA 30912 USA.
   [Ergul, Adviye] Med Coll Georgia, Dept Physiol & Grad Studies, Augusta, GA 30912 USA.
   [Gower, Barbara A.] Univ Alabama Birmingham, Dept Nutr Sci, Birmingham, AL 35294 USA.
   [Allison, Jerry D.] Med Coll Georgia, Dept Radiol, Augusta, GA 30912 USA.
   [Davis, Catherine L.] Med Coll Georgia, Dept Pediat, Georgia Prevent Ctr, Augusta, GA 30912 USA.
   [Davis, Catherine L.] Med Coll Georgia, Dept Physiol, Georgia Prevent Ctr, Augusta, GA 30912 USA.
   [Davis, Catherine L.] Med Coll Georgia, Dept Grad Studies, Georgia Prevent Ctr, Augusta, GA 30912 USA.
C3 University System of Georgia; Augusta University; University System of
   Georgia; Augusta University; University of Alabama System; University of
   Alabama Birmingham; University System of Georgia; Augusta University;
   University System of Georgia; Augusta University; University System of
   Georgia; Augusta University; University System of Georgia; Augusta
   University
RP Davis, CL (corresponding author), Med Coll Georgia, Inst Publ & Prevent Hlth, Georgia Prevent Ctr, HS-1711, Augusta, GA 30912 USA.
EM cadavis@gru.edu
RI Davis, Catherine/A-7522-2011
OI Davis, Catherine Lucy/0000-0002-2942-8233
FU National Institute of Diabetes and Digestive and Kidney Diseases [R01
   DK060692, P30 DK056336]
FX Funding was provided by grants from the National Institute of Diabetes
   and Digestive and Kidney Diseases to Dr. Davis, R01 DK060692 and to Dr.
   Gower, P30 DK056336.
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NR 43
TC 28
Z9 31
U1 0
U2 18
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 2153-2168
EI 2153-2176
J9 CHILD OBES
JI Child Obes.
PD FEB
PY 2013
VL 9
IS 1
BP 15
EP 21
DI 10.1089/chi.2011.0092
PG 7
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA AI4OX
UT WOS:000336845800004
PM 23270535
OA Green Published
DA 2025-06-11
ER

PT J
AU Hu, X
   Chen, LL
   Zheng, J
   Kong, W
   Zhang, HH
   Zeng, TS
   Zhang, JY
   Li, HQ
   Hu, D
   Liao, YF
AF Hu, Xiang
   Chen, Lu-Lu
   Zheng, Juan
   Kong, Wen
   Zhang, Hao-Hao
   Zeng, Tian-Shu
   Zhang, Jiao-Yue
   Li, Hui-Qing
   Hu, Di
   Liao, Yun-Fei
TI Increases in systemic and local stress: a probable mechanism of visceral
   fat accumulation and insulin resistance in adult catch-up growth rats?
SO EXPERIMENTAL BIOLOGY AND MEDICINE
LA English
DT Article
DE catch-up growth in adult; visceral fat accumulation; insulin resistance;
   stress; rats
ID 11-BETA-HYDROXYSTEROID DEHYDROGENASE-ACTIVITY; PITUITARY-ADRENAL
   ACTIVITY; ADIPOSE-TISSUE; METABOLIC SYNDROME; SKELETAL-MUSCLE;
   SUPPRESSED THERMOGENESIS; CALORIC RESTRICTION; GENE-EXPRESSION;
   DIABETIC-RATS; IN-VIVO
AB Catch-up growth in adult (CUGA) is increasingly proposed as an important causative factor for the widespread insulin resistance (IR)-related diseases especially in developing countries/territories. We aimed to investigate the effects of CUGA to insulin sensitivity, lipid profile and stress in rats, as well as the probable relationship among them. Male Sprague Dawley rats were randomly divided into six groups for two sampling points: caloric restriction group (R4) and normal chow controls for four weeks (NC4); CUGA re-fed with normal chow (RN4), CUGA re-fed with high-fat diet (RH4), normal chow controls (NC8) and high-fat diet controls (HF8) for eight weeks. Visceral fat accumulation (visceral adipose tissue [VAT] percentage), systemic (plasma corticosterone) and local (HSD11B1 mRNA expression in skeletal muscle [SkM] and VAT) stress, whole-body and peripheral insulin sensitivity were determined in this study. After four weeks of caloric restriction, R4 rats showed increases in systemic and local stress, decreases in visceral fat accumulation and no IR (whole-body or peripheral). Yet, after re-feeding, sustained systemic and local stress, remarkable visceral fat accumulation and IR (whole-body and peripheral) were found in RN4 compared with NC8, in RH4 compared with NC8 and HF8. Our findings demonstrated that CUGA rats were characterized by significant IR, visceral fat accumulation and stress. These changes were more severe in CUGA re-fed with high-fat diet. The interaction of sustained caloric restriction-induced stress and re-feeding might be of utmost importance in the etiology of visceral fat accumulation and IR in CUGA.
C1 [Hu, Xiang; Chen, Lu-Lu; Zheng, Juan; Kong, Wen; Zhang, Hao-Hao; Zeng, Tian-Shu; Zhang, Jiao-Yue; Li, Hui-Qing; Hu, Di; Liao, Yun-Fei] Huazhong Univ Sci & Technol, Tongji Med Coll, Union Hosp, Dept Endocrinol, Wuhan 430022, Peoples R China.
C3 Huazhong University of Science & Technology
RP Chen, LL (corresponding author), Huazhong Univ Sci & Technol, Tongji Med Coll, Union Hosp, Dept Endocrinol, Wuhan 430022, Peoples R China.
EM cheria_chen@126.com
RI Kong, Wen/GQH-3057-2022; li, fei/HJO-9520-2023; Chen, Lulu/AAV-2389-2021
FU National Natural Science Foundation of China [30771035, 81170782];
   Independent Innovation Fund of Huazhong University of Science and
   Technology [2012QN233]
FX This study was supported by National Natural Science Foundation of China
   (30771035 and 81170782) and the Independent Innovation Fund of Huazhong
   University of Science and Technology (2012QN233).
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NR 41
TC 8
Z9 16
U1 0
U2 13
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1535-3702
EI 1535-3699
J9 EXP BIOL MED
JI Exp. Biol. Med.
PD JAN
PY 2013
VL 238
IS 1
BP 57
EP 65
DI 10.1258/ebm.2012.012207
PG 9
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 107SA
UT WOS:000316239900008
PM 23479764
DA 2025-06-11
ER

PT J
AU Hakim, F
   Wang, Y
   Carreras, A
   Hirotsu, C
   Zhang, J
   Peris, E
   Gozal, D
AF Hakim, Fahed
   Wang, Yang
   Carreras, Alba
   Hirotsu, Camila
   Zhang, Jing
   Peris, Eduard
   Gozal, David
TI Chronic Sleep Fragmentation During the Sleep Period Induces Hypothalamic
   Endoplasmic Reticulum Stress and PTP1b-Mediated Leptin Resistance in
   Male Mice
SO SLEEP
LA English
DT Article
DE endoplasmic reticulum stress; leptin resistance; sleep fragmentation
ID UNFOLDED PROTEIN RESPONSE; BODY-WEIGHT; NEURAL INJURY; FOOD STIMULI; ER
   STRESS; OBESITY; DYSFUNCTION; MOUSE; DEFICIENCY; PATHWAY
AB Background: Sleep fragmentation (SF) is highly prevalent and may constitute an important contributing factor to excessive weight gain and the metabolic syndrome. Increased endoplasmic reticulum (ER) stress and activation of the unfolded protein response (UPR) leading to the attenuation of leptin receptor signaling in the hypothalamus leads to obesity and metabolic dysfunction.
   Methods: Mice were exposed to SF and sleep control (SC) for varying periods of time during which ingestive behaviors were monitored. UPR pathways and leptin receptor signaling were assessed in hypothalami. To further examine the mechanistic role of ER stress, changes in leptin receptor (ObR) signaling were also examined in wild-type mice treated with the ER chaperone tauroursodeoxycholic acid (TUDCA), as well as in CHOP -/+ transgenic mice.
   Results: Fragmented sleep in male mice induced increased food intake starting day 3 and thereafter, which was preceded by increases in ER stress and activation of all three UPR pathways in the hypothalamus. Although ObR expression was unchanged, signal transducer and activator of transcription 3 (STAT3) phosphorylation was decreased, suggesting reduced ObR signaling. Unchanged suppressor of cytokine signaling-3 (SOCS3) expression and increases in protein-tyrosine phosphatase 1B (PTP1B) expression and activity emerged with SF, along with reduced p-STAT3 responses to exogenous leptin. SF-induced effects were reversed following TUDCA treatment and were absent in CHOP -/+ mice.
   Conclusions: Sleep fragmentation (SF) induces hyperphagic behaviors and reduced leptin signaling in hypothalamus that are mediated by activation of endoplasmic reticulum (ER) stress, and ultimately lead to increased PTP1B activity. ER stress pathways are therefore potentially implicated in SF-induced weight gain and metabolic dysfunction, and may represent a viable therapeutic target.
C1 [Hakim, Fahed; Wang, Yang; Carreras, Alba; Hirotsu, Camila; Zhang, Jing; Peris, Eduard; Gozal, David] Univ Chicago, Dept Pediat, Sect Pediat Sleep Med, Comer Childrens Hosp,Biol Sci Div, Chicago, IL 60637 USA.
C3 University of Chicago
RP Gozal, D (corresponding author), Univ Chicago, Dept Pediat, 5721 S Maryland Ave,MC 8000,Suite K-160, Chicago, IL 60637 USA.
EM dgo-zal@uchicago.edu
RI Hirotsu, Camila/C-1960-2013; Wang, Hongyang/B-1340-2010; Gozal,
   David/ABH-3805-2020
OI Hirotsu, Camila/0000-0002-6760-0663; Peris Franquet,
   Eduard/0000-0002-9237-3263
FU National Institutes of Health [HL-065270, HL-086662]
FX This was not an industry supported study. Dr. Gozal is supported by
   National Institutes of Health grants HL-065270 and HL-086662. The other
   authors have indicated no financial conflicts of interest.
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NR 54
TC 69
Z9 70
U1 1
U2 19
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
EI 1550-9109
J9 SLEEP
JI Sleep
PD JAN 1
PY 2015
VL 38
IS 1
BP 31
EP U367
DI 10.5665/sleep.4320
PG 12
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA AX8OT
UT WOS:000347169300006
PM 25325461
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Lu, YX
   Cheng, JJ
   Chen, L
   Li, CF
   Chen, GJ
   Gui, L
   Shen, B
   Zhang, Q
AF Lu, Yunxia
   Cheng, Jingjing
   Chen, Li
   Li, Chaofei
   Chen, Guanjun
   Gui, Li
   Shen, Bing
   Zhang, Qiu
TI Endoplasmic reticulum stress involved in high-fat diet and palmitic
   acid-induced vascular damages and fenofibrate intervention
SO BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
LA English
DT Article
DE Endoplasmic reticulum stress; Endothelium-dependent vasodilatation;
   Fenofibrate; Endothelial nitric oxide synthase; High-fat diet; Palmitic
   acid
ID HEPATIC INSULIN-RESISTANCE; AORTIC ENDOTHELIAL-CELLS;
   DENSITY-LIPOPROTEIN; METABOLIC SYNDROME; NITRIC-OXIDE; DYSFUNCTION;
   ACTIVATION; APOPTOSIS; PROTEIN; MICE
AB Fenofibrate (FF) is widely used to lower blood lipids in clinical practice, but whether its protective effect on endothelium-dependent vasodilatation (EDV) in thoracic aorta is related with endoplasmic reticulum (ER) stress remains unknown. In this study, female Sprauge Dawley rats were divided into standard chow diets (SCD), high-fat diets (HFD) and HFD plus FF treatment group (HFD + FF) randomly. The rats of latter two groups were given HFD feeding for 5 months, then HFD + FF rats were treated with FF (30 mg/kg, once daily) via gavage for another 2 months. The pathological and tensional changes, protein expression of eNOS, and ER stress related genes in thoracic aorta were measured. Then impacts of palmitic acid (PA) and FF on EDV of thoracic aorta from normal female SD rats were observed. Ultimately the expression of ER stress related genes were assessed in primary mouse aortic endothelial cells (MAEC) treated by fenofibric acid (FA) and PA. We found that FF treatment improved serum lipid levels and pathological changes in thoracic aorta, accompanied with decreased ER stress and increased phosphorylation of eNOS. FF pretreatment also improved EDV impaired by different concentrations of PA treatment. The dose- and time-dependent inhibition of cell proliferation by PA were inverted by FA pretreatment. Phosphorylation of eNOS and expression of ER stress related genes were all inverted by FA pretreatment in PA-treated MAEC. Our findings show that fenofibrate recovers damaged EDV by chronic HFD feeding and acute stimulation of PA, this effect is related with decreased ER stress and increased phosphorylation of eNOS. (C) 2015 Published by Elsevier Inc.
C1 [Lu, Yunxia; Cheng, Jingjing; Chen, Li; Li, Chaofei; Chen, Guanjun] Anhui Med Univ, Dept Biochem & Mol Biol, Hefei 230032, Anhui, Peoples R China.
   [Lu, Yunxia; Gui, Li] Anhui Med Univ, Comprehens Lab, Hefei 230032, Anhui, Peoples R China.
   [Shen, Bing] Anhui Med Univ, Dept Physiol, Hefei 230032, Anhui, Peoples R China.
   [Chen, Li] Anhui Prov Hosp, Dept Lab Med, Hefei 230001, Anhui, Peoples R China.
   [Zhang, Qiu] Anhui Med Univ, Affiliated Hosp 1, Dept Endocrinol, Hefei 230022, Anhui, Peoples R China.
C3 Anhui Medical University; Anhui Medical University; Anhui Medical
   University; Anhui Medical University
RP Lu, YX (corresponding author), Anhui Med Univ, Dept Biochem & Mol Biol, Comprehens Lab, 81 Meishan Rd, Hefei 230032, Anhui, Peoples R China.
EM wwwdluyx@sina.com
RI Cheng, Jingjing/KHU-5683-2024; Lu, Yunxia/AAU-6408-2021; Guanjun,
   Chen/AAN-1550-2021; gui, li/GQQ-2739-2022
FU Anhui Medical University for Scientific Research of BSKY [XJ201013];
   Fund of Anhui Natural Science Foundation of China [1208085MH168,
   1308085MH154]
FX This work was supported by research grants from Anhui Medical University
   for Scientific Research of BSKY (XJ201013), Fund of Anhui Natural
   Science Foundation of China (1208085MH168 and 1308085MH154).
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NR 24
TC 22
Z9 25
U1 1
U2 15
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0006-291X
EI 1090-2104
J9 BIOCHEM BIOPH RES CO
JI Biochem. Biophys. Res. Commun.
PD FEB 27
PY 2015
VL 458
IS 1
BP 1
EP 7
DI 10.1016/j.bbrc.2014.12.123
PG 7
WC Biochemistry & Molecular Biology; Biophysics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics
GA CD7DB
UT WOS:000351249900001
PM 25592967
DA 2025-06-11
ER

PT J
AU Satoh, T
   Wang, LF
   Espinosa-Diez, C
   Wang, B
   Hahn, SA
   Noda, K
   Rochon, ER
   Dent, MR
   Levine, AR
   Baust, JJ
   Wyman, S
   Wu, YJL
   Triantafyllou, GA
   Tang, Y
   Reynolds, M
   Shiva, S
   St Hilaire, C
   Gomez, D
   Goncharov, DA
   Goncharova, EA
   Chan, SPY
   Straub, AC
   Lai, YC
   McTiernan, CF
   Gladwin, MT
AF Satoh, Taijyu
   Wang, Longfei
   Espinosa-Diez, Cristina
   Wang, Bing
   Hahn, Scott A.
   Noda, Kentaro
   Rochon, Elizabeth R.
   Dent, Matthew R.
   Levine, Andrea R.
   Baust, Jeffrey J.
   Wyman, Samuel
   Wu, Yijen L.
   Triantafyllou, Georgios A.
   Tang, Ying
   Reynolds, Mike
   Shiva, Sruti
   St Hilaire, Cynthia
   Gomez, Delphine
   Goncharov, Dmitry A.
   Goncharova, Elena A.
   Chan, Stephen Y.
   Straub, Adam C.
   Lai, Yen-Chun
   McTiernan, Charles F.
   Gladwin, Mark T.
TI Metabolic Syndrome Mediates ROS-miR-193b-NFYA-Dependent Downregulation
   of Soluble Guanylate Cyclase and Contributes to Exercise-Induced
   Pulmonary Hypertension in Heart Failure With Preserved Ejection Fraction
SO CIRCULATION
LA English
DT Article
DE MIRN193 microRNA; human; nitric oxide; nuclear factor Y; pulmonary
   hypertension
ID NUCLEAR FACTOR-Y; RIGHT-VENTRICULAR FUNCTION; NITRIC-OXIDE;
   ARTERIAL-HYPERTENSION; NAD(P)H OXIDASE; EXPRESSION; CGMP; EMPAGLIFLOZIN;
   PROLIFERATION; COMPLICATIONS
AB Background: Many patients with heart failure with preserved ejection fraction have metabolic syndrome and develop exercise-induced pulmonary hypertension (EIPH). Increases in pulmonary vascular resistance in patients with heart failure with preserved ejection fraction portend a poor prognosis; this phenotype is referred to as combined precapillary and postcapillary pulmonary hypertension (CpcPH). Therapeutic trials for EIPH and CpcPH have been disappointing, suggesting the need for strategies that target upstream mechanisms of disease. This work reports novel rat EIPH models and mechanisms of pulmonary vascular dysfunction centered around the transcriptional repression of the soluble guanylate cyclase (sGC) enzyme in pulmonary artery (PA) smooth muscle cells. Methods: We used obese ZSF-1 leptin-receptor knockout rats (heart failure with preserved ejection fraction model), obese ZSF-1 rats treated with SU5416 to stimulate resting pulmonary hypertension (obese+sugen, CpcPH model), and lean ZSF-1 rats (controls). Right and left ventricular hemodynamics were evaluated using implanted catheters during treadmill exercise. PA function was evaluated with magnetic resonance imaging and myography. Overexpression of nuclear factor Y alpha subunit (NFYA), a transcriptional enhancer of sGC beta 1 subunit (sGC beta 1), was performed by PA delivery of adeno-associated virus 6. Treatment groups received the SGLT2 inhibitor empagliflozin in drinking water. PA smooth muscle cells from rats and humans were cultured with palmitic acid, glucose, and insulin to induce metabolic stress. Results: Obese rats showed normal resting right ventricular systolic pressures, which significantly increased during exercise, modeling EIPH. Obese+sugen rats showed anatomic PA remodeling and developed elevated right ventricular systolic pressure at rest, which was exacerbated with exercise, modeling CpcPH. Myography and magnetic resonance imaging during dobutamine challenge revealed PA functional impairment of both obese groups. PAs of obese rats produced reactive oxygen species and decreased sGC beta 1 expression. Mechanistically, cultured PA smooth muscle cells from obese rats and humans with diabetes or treated with palmitic acid, glucose, and insulin showed increased mitochondrial reactive oxygen species, which enhanced miR-193b-dependent RNA degradation of nuclear factor Y alpha subunit (NFYA), resulting in decreased sGC beta 1-cGMP signaling. Forced NYFA expression by adeno-associated virus 6 delivery increased sGC beta 1 levels and improved exercise pulmonary hypertension in obese+sugen rats. Treatment of obese+sugen rats with empagliflozin improved metabolic syndrome, reduced mitochondrial reactive oxygen species and miR-193b levels, restored NFYA/sGC activity, and prevented EIPH. Conclusions: In heart failure with preserved ejection fraction and CpcPH models, metabolic syndrome contributes to pulmonary vascular dysfunction and EIPH through enhanced reactive oxygen species and miR-193b expression, which downregulates NFYA-dependent sGC beta 1 expression. Adeno-associated virus-mediated NFYA overexpression and SGLT2 inhibition restore NFYA-sGC beta 1-cGMP signaling and ameliorate EIPH.
C1 [Satoh, Taijyu; Wang, Longfei; Espinosa-Diez, Cristina; Hahn, Scott A.; Rochon, Elizabeth R.; Dent, Matthew R.; Baust, Jeffrey J.; Tang, Ying; Reynolds, Mike; Shiva, Sruti; St Hilaire, Cynthia; Gomez, Delphine; Goncharov, Dmitry A.; Goncharova, Elena A.; Chan, Stephen Y.; Straub, Adam C.; McTiernan, Charles F.; Gladwin, Mark T.] Univ Pittsburgh, Sch Med, Pittsburgh Heart Lung & Blood Vasc Med Inst, Pittsburgh, PA 15261 USA.
   [Triantafyllou, Georgios A.; Gladwin, Mark T.] Univ Pittsburgh, Sch Med, Div Pulm Allergy & Crit Care Med, Pittsburgh, PA USA.
   [Tang, Ying; St Hilaire, Cynthia; Gomez, Delphine; Chan, Stephen Y.] Univ Pittsburgh, Sch Med, Div Cardiol, Pittsburgh, PA USA.
   [Shiva, Sruti; Straub, Adam C.] Univ Pittsburgh, Sch Med, Dept Pharmacol & Chem Biol, Pittsburgh, PA USA.
   [St Hilaire, Cynthia; Goncharova, Elena A.] Univ Pittsburgh, Sch Med, Dept Bioengn, Pittsburgh, PA USA.
   [Wang, Bing] Univ Pittsburgh, Dept Orthoped Surg, Pittsburgh, PA USA.
   [Noda, Kentaro] Univ Pittsburgh, Div Lung Transplant & Lung Failure, Dept Cardiothorac Surg, Pittsburgh, PA USA.
   [Noda, Kentaro; Wyman, Samuel; Wu, Yijen L.] Univ Pittsburgh, Rangos Res Ctr Anim Imaging Core & Dev Biol, Pittsburgh, PA USA.
   [Levine, Andrea R.] Univ Maryland, Sch Med, Pulm & Crit Care Med, Baltimore, MD USA.
   [Goncharov, Dmitry A.; Goncharova, Elena A.] Univ Calif Davis, Div Pulm Crit Care & Sleep Med, Davis, CA USA.
   [Lai, Yen-Chun] Indiana Univ Sch Med, Div Pulm Crit Care Sleep & Occupat Med, Indiana, PA USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE); University
   of Pittsburgh; Pennsylvania Commonwealth System of Higher Education
   (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of
   Higher Education (PCSHE); University of Pittsburgh; Pennsylvania
   Commonwealth System of Higher Education (PCSHE); University of
   Pittsburgh; Pennsylvania Commonwealth System of Higher Education
   (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of
   Higher Education (PCSHE); University of Pittsburgh; Pennsylvania
   Commonwealth System of Higher Education (PCSHE); University of
   Pittsburgh; Pennsylvania Commonwealth System of Higher Education
   (PCSHE); University of Pittsburgh; University System of Maryland;
   University of Maryland Baltimore; University of California System;
   University of California Davis
RP Gladwin, MT (corresponding author), Univ Pittsburgh, Sch Med, Pittsburgh Heart Lung & Blood Vasc Med Inst, Pittsburgh, PA 15261 USA.
EM SATOHT@pitt.edu; bingwang@pitt.edu; ESPINOSA@pitt.edu;
   bingwang@pitt.edu; sch63@pitt.edu; nodak@upmc.edu; err26@pitt.edu;
   MRD109@pitt.edu; andrea.levine@som.umaryland.edu; jjb100@pitt.edu;
   samwyman17@gmail.com; yijenwu@pitt.edu; triantafylloug@upmc.edu;
   yit3@pitt.edu; MJR122@pitt.edu; sss43@pitt.edu; sthilaire@pitt.edu;
   gomezd@pitt.edu; dgoncharov@ucdavis.edu; eagoncharova@ucdavis.edu;
   chansy@upmc.edu; astraub@pitt.edu; yel19@pitt.edu; mctiernanc@upmc.edu;
   gladwinmt@upmc.edu
RI Gomez, Delphine/J-6349-2019; Wang, Wei/J-5604-2019; Noda,
   Kentaro/AAG-4268-2021; Yang, Chuntao/B-4389-2011; St. Hilaire,
   Cynthia/R-8205-2017
OI Reynolds, Michael/0000-0003-3550-0382; Dent,
   Matthew/0000-0002-7704-4867; St. Hilaire, Cynthia/0000-0003-1871-6915;
   Rochon, Elizabeth/0000-0002-6255-9817; Goncharova,
   Elena/0000-0001-7118-6752; Espinosa-Diez, Maria
   Cristina/0000-0002-5868-3807; Straub, Adam/0000-0003-0542-9466; Satoh,
   Taijyu/0000-0002-1795-6872; Gomez, Delphine/0000-0002-3880-6961
FU National Institutes of Health [5P01HL10345509, S10OD023684, R01 HL
   133864, R01 HL 128304, R21-EB023507, R01 HL142932, HL117917, R01
   HL133003-01A1, R01 HL146465, R01 HL113178, R01 HL130261, R01HL142638,
   R01HL124021, HL122596, HL138437, UH2/UH3 TR002073]; American Heart
   Association [18CDA34140024, 19 EIA34770095, 18EIA33900027]; US
   Department of Defense [W81XWH1810070]; Uehara Memorial Foundation; China
   Council Scholarship [CSC201706370266]; U.S. Department of Defense (DOD)
   [W81XWH1810070] Funding Source: U.S. Department of Defense (DOD);
   National Heart Lung and Blood Institute [R01HL122596, R01HL113178]
   Funding Source: NIH RePORTER; American Heart Association (AHA)
   [18CDA34140024] Funding Source: American Heart Association (AHA)
FX This study was supported by funds from the National Institutes of Health
   (5P01HL10345509, Gladwin principal investigator (PI); S10OD023684, Kang
   Kim PI; R01 HL 133864, R01 HL 128304, Straub PI; R21-EB023507, Wu PI;
   R01 HL142932 and HL117917, St Hilaire PI; R01 HL133003-01A1, Shiva PI;
   R01 HL146465, Gomez PI; R01 HL113178 and R01 HL130261, Goncharova PI;
   R01HL142638, Lai PI; R01HL124021, HL122596, HL138437, and UH2/UH3
   TR002073, Chan PI), American Heart Association (18CDA34140024, Wu PI;
   Established Investigator Grant 19 EIA34770095, Straub PI; Established
   Investigator Grant 18EIA33900027, Chan PI), US Department of Defense
   (W81XWH1810070, Wu PI), Children's Hospital of Pittsburgh (CHP00-CY19
   RAC, Wu PI), the Uehara Memorial Foundation Postdoctoral Fellowship
   (Taijyu Satoh), and China Council Scholarship (CSC201706370266, Longfei
   Wang).
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NR 69
TC 55
Z9 59
U1 2
U2 20
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0009-7322
EI 1524-4539
J9 CIRCULATION
JI Circulation
PD AUG 24
PY 2021
VL 144
IS 8
BP 615
EP 637
DI 10.1161/CIRCULATIONAHA.121.053889
PG 23
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA UE3PQ
UT WOS:000687804500011
PM 34157861
OA Green Accepted, Green Submitted, Bronze
DA 2025-06-11
ER

PT J
AU Tracy, CR
   Henning, JR
   Newton, MR
   Aviram, M
   Zimmerman, MB
AF Tracy, Chad R.
   Henning, Jonathan R.
   Newton, Mark R.
   Aviram, Michael
   Zimmerman, M. Bridget
TI Oxidative stress and nephrolithiasis: a comparative pilot study
   evaluating the effect of pomegranate extract on stone risk factors and
   elevated oxidative stress levels of recurrent stone formers and controls
SO UROLITHIASIS
LA English
DT Article
DE Nephrolithiasis; Medical management; Oxidative stress; Antioxidants;
   Dietary management; Renal disease
ID CALCIUM-OXALATE NEPHROLITHIASIS; CORONARY-HEART-DISEASE; KIDNEY-STONES;
   ETHYLENE-GLYCOL; LIPID-PEROXIDATION; METABOLIC SYNDROME;
   DIABETES-MELLITUS; NATIONAL-HEALTH; PARAOXONASE; JUICE
AB Previous studies have linked oxidative stress and nephrolithiasis. Animal studies have demonstrated that pomegranate juice may play a role in preventing stone formation. We examined differences between recurrent stone formers (RSFs) and non-stone formers (NSFs) regarding oxidative stress and the effect of pomegranate administration on risk factors for nephrolithiasis. RSFs were recruited prospectively and matched to a group of NSFs. Subjects submitted urine and blood samples prior to and after receiving pomegranate polyphenol extract (1,000 mg) for 90 days. Serum and urine samples were analyzed for stone risk and oxidative stress. Thirty subjects completed the study. RSFs had significantly higher levels of oxidative stress at baseline as measured by urinary 8-hydroxy-deoxyguanosine (p < 0.0001), 2.2'-azobis (2-amidinopropane) hydrochloride-induced serum lipid peroxidation [increased levels of lipid peroxides (p = 0.0002), and thiobarbituric acid reactive substances (p = 0.002)], but not by serum paraoxonase1 (PON1) arylesterase activity (p > 0.99), or by highly sensitive C-reactive protein (p > 0.99). Following pomegranate supplementation, there was a 10 % increase in PON1 activity in RSFs (p = 0.007), which correlated with a trend toward decreasing values of supersaturation of calcium oxalate (SSCaOx; p = 0.05). RSFs have markedly higher levels of oxidative stress than NSFs. While the ability to prevent stone formation through supplementation cannot be determined in this pilot study, supplementation with pomegranate extract does not increase the risk of stones and may confer some benefit in lowering SSCaOX in those patients with increased PON-1 levels following supplementation, confirming findings of previous animal models.
C1 [Tracy, Chad R.; Henning, Jonathan R.; Newton, Mark R.] Univ Iowa, Dept Urol, Iowa City, IA 52242 USA.
   [Aviram, Michael] Rambam Med Ctr, Rappaport Family Inst Res Med Sci, Lipid Res Lab, Haifa, Israel.
   [Zimmerman, M. Bridget] Univ Iowa, Dept Biostat, Iowa City, IA USA.
C3 University of Iowa; Technion Israel Institute of Technology; Rappaport
   Faculty of Medicine; Rambam Health Care Campus; University of Iowa
RP Tracy, CR (corresponding author), Univ Iowa, Dept Urol, 200 Hawkins Dr,3 RCP, Iowa City, IA 52242 USA.
EM chad-tracy@uiowa.edu
RI Newton, Mark/MXL-0489-2025
OI Tracy, Chad/0000-0002-3505-5402
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NR 33
TC 23
Z9 25
U1 0
U2 10
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 2194-7228
EI 2194-7236
J9 UROLITHIASIS
JI Urolithiasis
PD OCT
PY 2014
VL 42
IS 5
BP 401
EP 408
DI 10.1007/s00240-014-0686-8
PG 8
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA AP9ZC
UT WOS:000342439800005
PM 25085198
DA 2025-06-11
ER

PT J
AU Werdermann, M
   Berger, I
   Scriba, LD
   Santambrogio, A
   Schlinkert, P
   Brendel, H
   Morawietz, H
   Schedl, A
   Peitzsch, M
   King, AJF
   Andoniadou, CL
   Bornstein, SR
   Steenblock, C
AF Werdermann, Martin
   Berger, Ilona
   Scriba, Laura D.
   Santambrogio, Alice
   Schlinkert, Pia
   Brendel, Heike
   Morawietz, Henning
   Schedl, Andreas
   Peitzsch, Mirko
   King, Aileen J. F.
   Andoniadou, Cynthia L.
   Bornstein, Stefan R.
   Steenblock, Charlotte
TI Insulin and obesity transform hypothalamic-pituitary-adrenal axis
   stemness and function in a hyperactive state
SO MOLECULAR METABOLISM
LA English
DT Article
DE Adrenal; Pituitary; HPA axis; Progenitors; Obesity; Metabolic stress
ID CORTICOTROPIN-RELEASING-FACTOR; HIGH-FAT DIET; AGOUTI-RELATED PROTEIN;
   GENE-EXPRESSION; NEUROPEPTIDE-Y; CHRONIC STRESS; NEURAL STEM; CELLS;
   LEPTIN; MICE
AB Objective: Metabolic diseases are an increasing problem in society with the brain-metabolic axis as a master regulator of the human body for sustaining homeostasis under metabolic stress. However, metabolic inflammation and disease will trigger sustained activation of the hypothalamic-pituitary-adrenal axis. In this study, we investigated the role of metabolic stress on progenitor cells in the hypothalamic-pituitary adrenal axis.
   Methods: In vitro, we applied insulin and leptin to murine progenitor cells isolated from the pituitary and adrenal cortex and examined the role of these hormones on proliferation and differentiation. In vivo, we investigated two different mouse models of metabolic disease, obesity in leptindeficient ob/ob mice and obesity achieved via feeding with a high-fat diet.
   Results: Insulin was shown to lead to enhanced proliferation and differentiation of both pituitary and adrenocortical progenitors. No alterations in the progenitors were noted in our chronic metabolic stress models. However, hyperactivation of the hypothalamic-pituitary-adrenal axis was observed and the expression of the appetite-regulating genes Npy and Agrp changed in both the hypothalamus and adrenal.
   Conclusions: It is well-known that chronic stress and stress hormones such as glucocorticoids can induce metabolic changes including obesity and diabetes. In this article, we show for the first time that this might be based on an early sensitization of stem cells of the hypothalamic pituitary-adrenal axis. Thus, pituitary and adrenal progenitor cells exposed to high levels of insulin are metabolically primed to a hyper functional state leading to enhanced hormone production. Likewise, obese animals exhibit a hyperactive hypothalamic-pituitary-adrenal axis leading to adrenal hyperplasia. This might explain how stress in early life can increase the risk for developing metabolic syndrome in adulthood. (C) 2020 The Authors. Published by Elsevier GmbH.
C1 [Werdermann, Martin; Berger, Ilona; Scriba, Laura D.; Santambrogio, Alice; Andoniadou, Cynthia L.; Bornstein, Stefan R.; Steenblock, Charlotte] Tech Univ Dresden, Univ Hosp Carl Gustav Carus, Dept Internal Med 3, Fetscherstr 74, Dresden, Germany.
   [Santambrogio, Alice; Andoniadou, Cynthia L.] Kings Coll London, Guys Hosp, Ctr Craniofacial & Regenerat Biol, London SE1 9RT, England.
   [Schlinkert, Pia] Tech Univ Dresden, Univ Hosp Carl Gustav Carus, Dept Pharmacol & Toxicol, Fetscherstr 74, D-01307 Dresden, Germany.
   [Brendel, Heike; Morawietz, Henning] Tech Univ Dresden, Univ Hosp Carl Gustav Carus Dresden, Dept Med 3, Div Vasc Endothelium & Microcirculat, Fetscherstr 74, D-01307 Dresden, Germany.
   [Schedl, Andreas] Univ Cote Azur, INSERM, CNRS, IBV, Parc Valrose, F-06108 Nice, France.
   [Peitzsch, Mirko] Tech Univ Dresden, Univ Hosp Carl Gustav Carus, Inst Clin Chem & Lab Med, Fetscherstr 74, D-01307 Dresden, Germany.
   [King, Aileen J. F.] Kings Coll London, Sch Life Course Sci, Dept Diabet, London SE1 9RT, England.
   [Bornstein, Stefan R.] Kings Coll London, Diabet & Nutr Sci Div, Guys Campus, London SE1 1UL, England.
C3 Technische Universitat Dresden; Carl Gustav Carus University Hospital;
   University of London; King's College London; Guy's & St Thomas' NHS
   Foundation Trust; Technische Universitat Dresden; Carl Gustav Carus
   University Hospital; Technische Universitat Dresden; Carl Gustav Carus
   University Hospital; Institut National de la Sante et de la Recherche
   Medicale (Inserm); Centre National de la Recherche Scientifique (CNRS);
   Universite Cote d'Azur; Technische Universitat Dresden; Carl Gustav
   Carus University Hospital; University of London; King's College London;
   University of London; King's College London
RP Steenblock, C (corresponding author), Tech Univ Dresden, Dept Internal Med 3, Fetscherstr 74, D-01307 Dresden, Germany.
EM martin.werdermann@uniklinikum-dresden.de;
   ilona.berger@uniklinikum-dresden.de;
   laura.scriba@uniklinikum-dresden.de; alice.santambrogio@kcl.ac.uk;
   pia.schlinkert@tu-dresden.de; heike.brendel@uniklinikum-dresden.de;
   henning.morawietz@uniklinikum-dresden.de; andreas.schedl@unice.fr;
   mirko.peitzsch@uniklinikum-dresden.de; aileen.king@kcl.ac.uk;
   cynthia.andoniadou@kcl.ac.uk; stefan.bornstein@uniklinikum-dresden.de;
   charlotte.steenblock@uniklinikum-dresden.de
RI Peitzsch, Mirko/LWK-6489-2024; Steenblock, Charlotte/C-9038-2018;
   Andoniadou, Cynthia/B-8412-2012; King, Aileen Jean Fiona/I-5935-2013;
   Schedl, Andreas/F-8823-2015
OI King, Aileen Jean Fiona/0000-0001-5759-7985; Steenblock,
   Charlotte/0000-0002-9635-4860; Schedl, Andreas/0000-0001-9380-7396;
   Berger, Ilona/0000-0001-6362-5903; Brendel, Heike/0000-0003-1214-1807
FU Deutsche Forschungsgemeinschaft (DFG, German Research foundation)
   [314061271, 288034826]
FX This work was supported by the Deutsche Forschungsgemeinschaft (DFG,
   German Research foundation) project no. 314061271, TRR 205/1: "The
   Adrenal: Central Relay in Health and Disease" and project no. 288034826,
   IRTG 2251: "Immunological and Cellular Strategies in Metabolic Disease".
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NR 83
TC 28
Z9 29
U1 2
U2 9
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2212-8778
J9 MOL METAB
JI Mol. Metab.
PD JAN
PY 2021
VL 43
AR 101112
DI 10.1016/j.molmet.2020.101112
EA JAN 2021
PG 13
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA PQ7RS
UT WOS:000606741800006
PM 33157254
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Balcioglu, SSK
   Sabitay, IK
   Uysal, A
   Servi, EY
   Yaman, M
   Mizrak, OF
   Ozturk, N
   Isiksacan, N
   Guclu, O
AF Balcioglu, Simge Seren Kirlioglu
   Sabitay, Imren Kurt
   Uysal, Aybegum
   Servi, Esra Yildirim
   Yaman, Mustafa
   Mizrak, Omer Faruk
   Ozturk, Nalan
   Isiksacan, Nilgun
   Guclu, Oya
TI Evaluation of changes in carbonyl stress markers with treatment in male
   patients with bipolar disorder manic episode: A controlled study
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Carbonyl stress; Bipolar disorder; Manic episode; Neurotoxicity;
   Inflammation
ID GLYCATION END-PRODUCTS; OXIDATIVE STRESS; METHYLGLYOXAL; DISEASE;
   ASSOCIATION; DAMAGE
AB Background: Carbonyl stress, a metabolic state characterized by elevated production of reactive carbonyl compounds (RCCs), is closely related to oxidative stress and has been implicated in various diseases. This study aims to investigate carbonyl stress parameters in drug-free bipolar disorder (BD) patients compared to healthy controls, explore their relationship with clinical features, and assess the effect of treatment on these parameters. Methods: Patients with a primary diagnosis of a manic episode of BD and healthy controls were recruited. Exclusion criteria included intellectual disability, presence of neurological diseases, chronic medical conditions such as diabetes mellitus and metabolic syndrome, and clinical signs of inflammation. Levels of serum carbonyl stress parameters were determined using high-performance liquid chromatography. Results: Levels of glyoxal (GO) and methylglyoxal (MGO) did not differ between pre- and post-treatment patients, but malondialdehyde (MDA) levels decreased significantly post-treatment. Pre-treatment MGO and MDA levels were higher in patients compared to controls, and these differences persisted post-treatment. After adjusting for BMI and waist circumference, only MDA levels remained significantly higher in patients compared to controls. Limitations: The study's limitations include the exclusion of female patients, which precluded any assessment of potential gender differences, and the lack of analysis of the effect of specific mood stabilizers or antipsychotic drugs. Conclusions: This study is the first to focus on carbonyl stress markers in BD, specifically GO, MGO, and MDA. MDA levels remained significantly higher in patients, suggesting a potential role in BD pathophysiology. MGO levels were influenced by metabolic parameters, indicating a potential link to neurotoxicity in BD. Further research with larger cohorts is needed to better understand the role of RCCs in BD and their potential as therapeutic targets.
C1 [Balcioglu, Simge Seren Kirlioglu; Sabitay, Imren Kurt; Uysal, Aybegum; Guclu, Oya] Univ Hlth Sci, Basaksehir Cam & Sakura City Hosp, Dept Psychiat, TR-34488 Istanbul, Turkiye.
   [Balcioglu, Simge Seren Kirlioglu; Isiksacan, Nilgun] Univ Hlth Sci, Hamidiye Inst Hlth Sci, Istanbul, Turkiye.
   [Servi, Esra Yildirim; Yaman, Mustafa] Istanbul Sabahattin Zaim Univ, Fac Engn & Nat Sci, Dept Mol Biol & Genet, Istanbul, Turkiye.
   [Mizrak, Omer Faruk] Istanbul Sabahattin Zaim Univ, Sabri Ulker Food & Nutr Ctr, Istanbul, Turkiye.
   [Ozturk, Nalan; Isiksacan, Nilgun] Dr Sadi Konuk Training & Res Hosp, Dept Biochem, Istanbul, Turkiye.
C3 University of Health Sciences Turkey; Istanbul Sabahattin Zaim
   University; Istanbul Sabahattin Zaim University
RP Balcioglu, SSK (corresponding author), Univ Hlth Sci, Basaksehir Cam & Sakura City Hosp, Dept Psychiat, TR-34488 Istanbul, Turkiye.
EM simgekirlioglu@gmail.com
RI Yaman, Mustafa/AAB-7380-2021; Kirlioglu Balcioglu, Simge
   Seren/GQQ-6459-2022; Kurt Sabitay, Imren/KVB-5903-2024
OI Kurt Sabitay, Imren/0000-0002-1073-3000; Kirlioglu Balcioglu, Simge
   Seren/0000-0001-9778-6617
FU Istanbul Sabahattin Zaim University Sabri Ulker Food and Nutrition
   Center, Turkiye
FX This study was supported by Istanbul Sabahattin Zaim University Sabri
   Ulker Food and Nutrition Center, Turkiye.
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NR 53
TC 0
Z9 0
U1 1
U2 2
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD OCT 1
PY 2024
VL 362
BP 1
EP 8
DI 10.1016/j.jad.2024.06.112
EA JUN 2024
PG 8
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA A3U8W
UT WOS:001281825600001
PM 38944288
DA 2025-06-11
ER

PT J
AU Kishi, T
   Matsuda, Y
   Matsunaga, S
   Mukai, T
   Moriwaki, M
   Tabuse, H
   Fujita, K
   Iwata, N
AF Kishi, Taro
   Matsuda, Yuki
   Matsunaga, Shinji
   Mukai, Tomohiko
   Moriwaki, Masatsugu
   Tabuse, Hideaki
   Fujita, Kiyoshi
   Iwata, Nakao
TI A randomized trial of aripiprazole vs blonanserin for the treatment of
   acute schizophrenia and related disorders
SO NEUROPSYCHIATRIC DISEASE AND TREATMENT
LA English
DT Article
DE aripiprazole; blonanserin; schizophrenia; efficacy; safety; randomized
   trial
ID CARDIOMETABOLIC RISK; DOUBLE-BLIND; EFFICACY; METAANALYSIS; GUIDELINES;
   OLANZAPINE; SAFETY; SCALE
AB Objective: There has been no direct comparison of aripiprazole and blonanserin for schizophrenia treatment. We conducted a 24-week, rater-masked, randomized trial of aripiprazole (6-30 mg/d) vs blonanserin (4-24 mg/d) in schizophrenia patients who were not taking any antipsychotic medication for more than 2 weeks before enrollment (UMIN000011194).
   Methods: The primary outcome measure for efficacy was improvement of Positive and Negative Syndrome Scale (PANSS) total score at week 24. Secondary outcomes were PANSS subscale scores, 21-item Hamilton Rating Scale for Depression (HAMD-21) score, response rate, discontinuation rate, and individual adverse events.
   Results: Forty-four patients were recruited. The discontinuation rate was 86.4% in the aripiprazole group and 68.2% in the blonanserin treatment group. There was no significant difference in mean time to discontinuation between the groups. Although both treatment groups showed significant reductions in the PANSS total score, PANSS subscale scores, and HAMD-21 scores at week 24, the magnitudes of the changes did not differ between the groups. There were no significant differences in the incidences of adverse events including somnolence, extrapyramidal symptoms, prolactin-related adverse events, and weight change between the groups.
   Conclusion: Our results suggest similar efficacy and safety profiles of aripiprazole and blonanserin in the patients with schizophrenia. Double-blind controlled studies are needed to further explore the efficacy and safety of aripiprazole and blonanserin in schizophrenia.
C1 [Kishi, Taro; Matsuda, Yuki; Matsunaga, Shinji; Mukai, Tomohiko; Moriwaki, Masatsugu; Iwata, Nakao] Fujita Hlth Univ, Sch Med, Dept Psychiat, 1-98 Dengakugakubo,Kutsukake Cho, Toyoake, Aichi 4701192, Japan.
   [Mukai, Tomohiko; Moriwaki, Masatsugu; Fujita, Kiyoshi] Okehazama Hosp, Dept Psychiat, Toyoake, Aichi, Japan.
   [Tabuse, Hideaki] Holy Cross Hosp, Dept Psychiat, Toki, Gifu, Japan.
C3 Fujita Health University
RP Kishi, T (corresponding author), Fujita Hlth Univ, Sch Med, Dept Psychiat, 1-98 Dengakugakubo,Kutsukake Cho, Toyoake, Aichi 4701192, Japan.
EM tarok@fujita-hu.ac.jp
RI Matsuda, Yuki/IAR-1252-2023
OI Matsuda, Yuki/0000-0001-7312-1266; IWATA, Nakao/0000-0003-3189-6076
FU Fujita Health University School of Medicine; ninth research group for
   schizophrenia
FX We thank the following colleagues who shared their data with us: Ichiro
   Yasue, MD, Kengo Miyahara, MD, PhD, Tatsuyo Suzuki, MD, PhD, Mari Nitta,
   MD, PhD, Miho Hattori, MD, PhD, Akiko Okuda, MD, PhD, Shinya Mitani, MD,
   PhD, Sakurako Tanaka, MD, PhD, Kayo Okada, MD, PhD, Yueren Zhao, MD,
   PhD, Takeo Saito, MD, PhD, Rika Tsuji, MD, Ms M Okuda-Hirabayashi, Ms M
   Yamamoto, Ms R Nishioka, Mr S Tsuboi, and Ms K Torii. This study was
   supported by Fujita Health University School of Medicine research grant
   and grant of the ninth research group for schizophrenia.
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NR 23
TC 8
Z9 11
U1 1
U2 8
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
EI 1178-2021
J9 NEUROPSYCH DIS TREAT
JI Neuropsychiatr. Dis. Treat.
PY 2016
VL 12
BP 3041
EP 3049
DI 10.2147/NDT.S121588
PG 9
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA ED2CH
UT WOS:000388650700001
PM 27932884
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Dokras, A
   Witchel, SF
AF Dokras, Anuja
   Witchel, Selma Feldman
TI Are Young Adult Women With Polycystic Ovary Syndrome Slipping Through
   the Healthcare Cracks?
SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Article
AB Polycystic ovary syndrome (PCOS) is a common endocrine disorder often diagnosed in adolescence or early adulthood. In adolescence, the many similarities between normal features of puberty and symptoms of PCOS make it challenging to confirm the diagnosis. Even among adult women, the changing definitions of PCOS may lead to inaccurate diagnoses. Women may present with a variety of symptoms to different healthcare providers and may be treated only for the presenting symptoms without evaluation of the syndrome and its associated morbidities. Timely evaluations, accurate diagnosis, appropriate interventions, and multidisciplinary healthcare teams can be valuable because women with PCOS have an increased risk for obesity, impaired glucose tolerance, diabetes, dyslipidemia, metabolic syndrome, infertility, endometrial cancer, and anxiety and mood disorders. Appropriate transition of care for the adolescent from pediatric to adult healthcare providers should include education of the patient and her parents regarding the chronic nature of the syndrome and the need for continued follow-up. Girls with symptoms suggestive of PCOS who fail to fulfill diagnostic criteria should undergo prolonged observation. Early identification of PCOS at different entry points in the healthcare system will require physician education and improved access.
C1 [Dokras, Anuja] Univ Penn, Dept Obstet & Gynecol, Div Reprod Endocrinol, Philadelphia, PA 19104 USA.
   [Witchel, Selma Feldman] UPMC, Childrens Hosp Pittsburgh, Div Pediat Endocrinol, Pittsburgh, PA 15224 USA.
C3 University of Pennsylvania; Pennsylvania Commonwealth System of Higher
   Education (PCSHE); University of Pittsburgh
RP Witchel, SF (corresponding author), Univ Pittsburgh, UPMC, Childrens Hosp Pittsburgh, Dept Pediat,Div Pediat Endocrinol, Pittsburgh, PA 15224 USA.
EM selma.witchel@chp.edu
CR [Anonymous], 2009, Obstet Gynecol, V114, P936, DOI 10.1097/AOG.0b013e3181bd12cb
   [Anonymous], POLYCYSTIC OVARY SYN
   [Anonymous], OXFORD ILLUSTRATED B
   [Anonymous], FERTIL STERIL
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NR 12
TC 28
Z9 31
U1 1
U2 12
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0021-972X
EI 1945-7197
J9 J CLIN ENDOCR METAB
JI J. Clin. Endocrinol. Metab.
PD MAY
PY 2014
VL 99
IS 5
BP 1583
EP 1585
DI 10.1210/jc.2013-4190
PG 3
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA AP8PB
UT WOS:000342339800037
PM 24606098
OA Bronze
DA 2025-06-11
ER

PT J
AU Salvadó, L
   Coll, T
   Gómez-Foix, AM
   Salmerón, E
   Barroso, E
   Palomer, X
   Vázquez-Carrera, M
AF Salvado, L.
   Coll, T.
   Gomez-Foix, A. M.
   Salmeron, E.
   Barroso, E.
   Palomer, X.
   Vazquez-Carrera, M.
TI Oleate prevents saturated-fatty-acid-induced ER stress, inflammation and
   insulin resistance in skeletal muscle cells through an AMPK-dependent
   mechanism
SO DIABETOLOGIA
LA English
DT Article
DE AMPK; ATF3; CHOP; ER stress; IL-6; NF-kappa B; Oleate; Palmitate; PPAR;
   XBP1
ID ENDOPLASMIC-RETICULUM STRESS; ACTIVATED PROTEIN-KINASE; NF-KAPPA-B;
   GLUCOSE-HOMEOSTASIS; METABOLIC SYNDROME; DIABETES-MELLITUS; BETA-CELLS;
   IN-VIVO; PALMITATE; DIET
AB Although the substitution of saturated fatty acids with oleate has been recommended in the management of type 2 diabetes mellitus, the mechanisms by which oleate improves insulin resistance in skeletal muscle cells are not completely known. Here, we examined whether oleate, through activation of AMP-activated protein kinase (AMPK), prevented palmitate-induced endoplasmic reticulum (ER) stress, which is involved in the link between lipid-induced inflammation and insulin resistance.
   Studies were conducted in mouse C2C12 myotubes and in the human myogenic cell line LHCN-M2. To analyse the involvement of AMPK, activators and inhibitors of this kinase and overexpression of a dominant negative AMPK construct (K45R) were used.
   Palmitate increased the levels of ER stress markers, whereas oleate did not. In palmitate-exposed cells incubated with a lower concentration of oleate, the effects of palmitate were prevented. The induction of ER stress markers by palmitate was prevented by the presence of the AMPK activators AICAR and A-769662. Moreover, the ability of oleate to prevent palmitate-induced ER stress and inflammation (nuclear factor-kappa B [NF-kappa B] DNA-binding activity and expression and secretion of IL6) as well as insulin-stimulated Akt phosphorylation and 2-deoxyglucose uptake was reversed in the presence of the AMPK inhibitor compound C or by overexpression of a dominant negative AMPK construct. Finally, palmitate reduced phospho-AMPK levels, whereas this was not observed in oleate-exposed cells or in palmitate-exposed cells supplemented with oleate.
   Overall, these findings indicate that oleate prevents ER stress, inflammation and insulin resistance in palmitate-exposed skeletal muscle cells by activating AMPK.
C1 [Salvado, L.; Coll, T.; Salmeron, E.; Barroso, E.; Palomer, X.; Vazquez-Carrera, M.] Univ Barcelona, Fac Pharm, Dept Pharmacol & Therapeut Chem, Pharmacol Unit, E-08028 Barcelona, Spain.
   [Salvado, L.; Coll, T.; Gomez-Foix, A. M.; Salmeron, E.; Barroso, E.; Palomer, X.; Vazquez-Carrera, M.] IBUB, Barcelona, Spain.
   [Gomez-Foix, A. M.] Univ Barcelona, Fac Biol, Dept Biochem & Mol Biol, E-08028 Barcelona, Spain.
C3 University of Barcelona; University of Barcelona; University of
   Barcelona
RP Vázquez-Carrera, M (corresponding author), Univ Barcelona, Fac Pharm, Dept Pharmacol & Therapeut Chem, Pharmacol Unit, Diagonal 643, E-08028 Barcelona, Spain.
EM mvazquezcarrera@ub.edu
RI Barroso, Emma/JXY-3878-2024; Vazquez-Carrera, Manuel/H-2612-2015;
   Barroso, Emma/G-9305-2018
OI Vazquez-Carrera, Manuel/0000-0001-7138-8207; Palomer,
   Xavier/0000-0001-7647-9984; Barroso, Emma/0000-0003-4551-4825
FU Spanish Ministerio de Economia y Competitividad [SAF2009-06939,
   SAF2012-30708]; European Union; FPI grant from the Spanish Ministerio de
   Economia y Competitividad
FX This study was partly supported by funds from the Spanish Ministerio de
   Economia y Competitividad (SAF2009-06939 and SAF2012-30708) and European
   Union ERDF funds. CIBER de Diabetes y Enfermedades Metabolicas Asociadas
   (CIBERDEM) is an Instituto de Salud Carlos III project. L. Salvado was
   supported by an FPI grant from the Spanish Ministerio de Economia y
   Competitividad.
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NR 49
TC 168
Z9 186
U1 0
U2 54
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0012-186X
J9 DIABETOLOGIA
JI Diabetologia
PD JUN
PY 2013
VL 56
IS 6
BP 1372
EP 1382
DI 10.1007/s00125-013-2867-3
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 142HI
UT WOS:000318787600020
PM 23460021
DA 2025-06-11
ER

PT S
AU Shakour, N
   Cabezas, R
   Santos, JG
   Barreto, GE
   Jamialahmadi, T
   Hadizadeh, F
   Sahebkar, A
AF Shakour, Neda
   Cabezas, Ricardo
   Gonzalez Santos, Janneth
   Barreto, George E.
   Jamialahmadi, Tannaz
   Hadizadeh, Farzin
   Sahebkar, Amirhossein
BE Barreto, GE
   Sahebkar, A
TI Curcumin Can Bind and Interact with CRP: An in silico Study
SO PHARMACOLOGICAL PROPERTIES OF PLANT-DERIVED NATURAL PRODUCTS AND
   IMPLICATIONS FOR HUMAN HEALTH
SE Advances in Experimental Medicine and Biology
LA English
DT Article; Book Chapter
DE Curcumin; Curcumin derivatives; C-reactive protein; Molecular docking;
   Molecular dynamic simulation
ID C-REACTIVE PROTEIN; PROLIFERATION; CANDIDATE; COMPOUND
AB Curcuminis a polyphenol with anti-inflammatory and antioxidative properties, found primarily in turmeric, a flowering plant of the ginger family. Among its numerous medical uses, curcumin has been used in the management of metabolic syndrome, and inflammatory conditions such as artrhritis, anxiety and hyperlipidemia. In this paper, we used molecular docking tools to assess the affinity of four curcumin derivatives (Curcumin, Cyclocurcumin, Demethoxycurcumin, Bisdemethoxycurcumin) as well as the endogenous ligand phosphorylcholine to C-reactive protein (CRP), a sensitive marker of systemic inflammation. Our results showed that curcumin interacts through H bond with CRP at GLN 150 and ASP 140. Similar H bond interactions were found for each of the four curcumin derivatives with CRP. Moreover, a molecular dynamic simulation were performed to further establish the interaction between CRP and the ligands in atomic details using the Nanoscale Molecular Dynamics (NAMD) and CHARMM27 force field. Importantly, our results suggest the possible interaction between curcumin and curcurmin related molecules with CRP, thus showing an important regulatory function with plausible applications in inflammatory and oxidative processes in diseases.
C1 [Shakour, Neda; Hadizadeh, Farzin] Mashhad Univ Med Sci, Sch Pharm, Dept Med Chem, Mashhad, Razavi Khorasan, Iran.
   [Cabezas, Ricardo] Univ Antonio Narino, Sch Med, Dept Physiol, Bogota, Colombia.
   [Gonzalez Santos, Janneth] Pontificia Univ Javeriana, Dept Nutr & Bioquim, Bogota, Colombia.
   [Barreto, George E.] Univ Limerick, Dept Biol Sci, Limerick, Ireland.
   [Barreto, George E.] Univ Limerick, Hlth Res Inst, Limerick, Ireland.
   [Jamialahmadi, Tannaz] Islamic Azad Univ, Dept Food Sci & Technol, Quchan Branch, Quchan, Iran.
   [Jamialahmadi, Tannaz] Mashhad Univ Med Sci, Fac Med, Dept Nutr, Mashhad, Razavi Khorasan, Iran.
   [Hadizadeh, Farzin; Sahebkar, Amirhossein] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Biotechnol Res Ctr, Mashhad, Razavi Khorasan, Iran.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Appl Biomed Res Ctr, Mashhad, Razavi Khorasan, Iran.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Sch Pharm, Mashhad, Razavi Khorasan, Iran.
   [Sahebkar, Amirhossein] Polish Mothers Mem Hosp Res Inst PMMHRI, Lodz, Poland.
C3 Mashhad University of Medical Sciences; Universidad Antonio Narino;
   Pontificia Universidad Javeriana; University of Limerick; University of
   Limerick; Islamic Azad University; Mashhad University of Medical
   Sciences; Mashhad University of Medical Sciences; Mashhad University of
   Medical Sciences; Mashhad University of Medical Sciences
RP Hadizadeh, F (corresponding author), Mashhad Univ Med Sci, Sch Pharm, Dept Med Chem, Mashhad, Razavi Khorasan, Iran.; Hadizadeh, F; Sahebkar, A (corresponding author), Mashhad Univ Med Sci, Pharmaceut Technol Inst, Biotechnol Res Ctr, Mashhad, Razavi Khorasan, Iran.; Sahebkar, A (corresponding author), Mashhad Univ Med Sci, Appl Biomed Res Ctr, Mashhad, Razavi Khorasan, Iran.; Sahebkar, A (corresponding author), Mashhad Univ Med Sci, Sch Pharm, Mashhad, Razavi Khorasan, Iran.; Sahebkar, A (corresponding author), Polish Mothers Mem Hosp Res Inst PMMHRI, Lodz, Poland.
EM hadizadehf@mums.ac.ir; sahebkara@mums.ac.ir
RI Barreto, George E./LQJ-8882-2024; Sahebkar, Amirhossein/B-5124-2018;
   Santos-Junior, Jair/B-1880-2016; shakour, neda/ADU-5645-2022
OI Jami, Tannaz/0000-0001-9521-3153; Shakour, Neda/0000-0002-9874-1397
CR Adibian M, 2019, PHYTOTHER RES, V33, P1374, DOI 10.1002/ptr.6328
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NR 41
TC 15
Z9 15
U1 2
U2 10
PU SPRINGER INTERNATIONAL PUBLISHING AG
PI CHAM
PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND
SN 0065-2598
EI 2214-8019
BN 978-3-030-64872-5; 978-3-030-64871-8
J9 ADV EXP MED BIOL
JI Adv.Exp.Med.Biol.
PY 2021
VL 1308
BP 91
EP 100
DI 10.1007/978-3-030-64872-5_7
D2 10.1007/978-3-030-64872-5
PG 10
WC Chemistry, Medicinal; Medicine, Research & Experimental; Pharmacology &
   Pharmacy
WE Book Citation Index – Science (BKCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Research & Experimental Medicine
GA BR3MG
UT WOS:000647701200007
PM 33861438
DA 2025-06-11
ER

PT J
AU Li, H
   Zhong, CR
   Wang, Q
   Chen, WK
   Yuan, Y
AF Li, He
   Zhong, Canrong
   Wang, Qian
   Chen, Weikang
   Yuan, Yan
TI Curcumin is an APE1 redox inhibitor and exhibits an antiviral activity
   against KSHV replication and pathogenesis
SO ANTIVIRAL RESEARCH
LA English
DT Article
ID DNA-REPAIR; APURINIC/APYRIMIDINIC ENDONUCLEASE-1; TRANSCRIPTION FACTOR;
   PROTEIN APE1/REF-1; ACTIVATION; CELLS; REF-1; STABILIZATION; MODULATION;
   HYPOXIA
AB Curcumin, a polyphenol, is the main bioactive compound in dietary spice turmeric curcuma longa. It possesses anti-inflammatory, anti-oxidant and anti-neoplastic properties and shows potentials in treating or preventing particular diseases such as oxidative and inflammatory conditions, metabolic syndrome, arthritis, anxiety, hyperlipidemia and cancers. The diverse range and potential health beneficial effects has generated enthusiasm leading to intensive investigation into the phytochemical. However, a concern has been also raised if curcumin has a promiscuous bioassay profile and is a Pan-Assay INterference compound (PAINS). Here we present evidence indicating that curcumin is not a PAINS, but an inhibitor to APE1 redox function that affects many genes and pathways. This discovery explains the wide range of effects of curcumin on diverse human diseases and predicts a potential application in treatment of viral infection and virus-associated cancer. As a proof-of-concept, we demonstrated that curcumin is able to efficiently block Kaposi's sarcoma-associated herpesvirus replication and inhibit the pathogenic processes of angiogenesis and cell invasion.
C1 [Li, He; Yuan, Yan] Univ Penn, Dept Microbiol, Sch Dent Med, Philadelphia, PA 19104 USA.
   [Li, He] Beihua Univ, Dept Pharmacol, Coll Pharm, Jilin, Jilin, Peoples R China.
   [Zhong, Canrong; Wang, Qian; Chen, Weikang; Yuan, Yan] Sun Yat Sen Univ, Inst Human Virol, Zhongshan Sch Med, Guangzhou, Guangdong, Peoples R China.
C3 University of Pennsylvania; Beihua University; Sun Yat Sen University
RP Yuan, Y (corresponding author), Univ Penn, Dept Microbiol, Sch Dent Med, Philadelphia, PA 19104 USA.
EM yuan2@upenn.edu
FU National Institutes of Health [P01CA174439, R01DE027901]; China
   Scholarship Council scholar project
FX We thank members of Yuan Lab, especially Lorenzo Gonzalez-Molleda and
   Louis Taylor, for their support and discussion. We are grateful to Dr.
   Manunya Nuth at the University of Pennsylvania for technical help and
   constructive discussion. This work was supported by National Institutes
   of Health grants P01CA174439 and R01DE027901. HL is supported by a China
   Scholarship Council scholar project.
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NR 34
TC 36
Z9 38
U1 0
U2 24
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0166-3542
EI 1872-9096
J9 ANTIVIR RES
JI Antiviral Res.
PD JUL
PY 2019
VL 167
BP 98
EP 103
DI 10.1016/j.antiviral.2019.04.011
PG 6
WC Pharmacology & Pharmacy; Virology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Virology
GA IE2WB
UT WOS:000472244200011
PM 31034848
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Bauer, KC
   Littlejohn, PT
   Ayala, V
   Creus-Cuadros, A
   Finlay, BB
AF Bauer, Kylynda C.
   Littlejohn, Paula T.
   Ayala, Victoria
   Creus-Cuadros, Anna
   Finlay, B. Brett
TI Nonalcoholic Fatty Liver Disease and the Gut-Liver Axis: Exploring an
   Undernutrition Perspective
SO GASTROENTEROLOGY
LA English
DT Article
DE Gut Microbiome; NAFLD; Gut-Liver Axis; Malnutrition; Undernutrition
ID SELENIUM CO-SUPPLEMENTATION; HEPATIC GLUCOSE-METABOLISM; OXIDATIVE
   STRESS; VITAMIN-E; INTESTINAL PERMEABILITY; CHILD UNDERNUTRITION;
   BILE-ACIDS; MICROBIOTA; ZINC; COPPER
AB Nonalcoholic fatty liver disease (NAFLD) is a chronic condition affecting one quarter of the global population. Although primarily linked to obesity and metabolic syndrome, undernutrition and the altered (dysbiotic) gut microbiome influence NAFLD progression. Both undernutrition and NAFLD prevalence are predicted to considerably increase, but how the undernourished gut microbiome contributes to hepatic pathophysiology remains far less studied. Here, we present undernutrition conditions with fatty liver features, including kwashiorkor and micronutrient deficiency. We then review the gut microbiota-liver axis, highlighting key pathways linked to NAFLD progression within both overnutrition and undernutrition. To conclude, we identify challenges and collaborative possibilities of emerging multiomic research addressing the pathology and treatment of undernourished NAFLD.
C1 [Bauer, Kylynda C.; Littlejohn, Paula T.; Creus-Cuadros, Anna; Finlay, B. Brett] Univ British Columbia, Michael Smith Labs, Vancouver, BC, Canada.
   [Bauer, Kylynda C.; Littlejohn, Paula T.; Finlay, B. Brett] Univ British Columbia, Dept Microbiol & Immunol, 2185 East Mall, Vancouver, BC V6T 1Z4, Canada.
   [Bauer, Kylynda C.] NCI, Thorac & Gastrointestinal Malignancies Branch, Ctr Canc Res, NIH, Bethesda, MD 20892 USA.
   [Ayala, Victoria] Inst Recerca Biomed Lleida IRB Lleida, Lleida, Spain.
   [Ayala, Victoria] Univ Lleida, Dept Expt Med, Lleida, Spain.
   [Finlay, B. Brett] Univ British Columbia, Biochem & Mol Biol Dept, Vancouver, BC, Canada.
C3 University of British Columbia; University of British Columbia; National
   Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI);
   Institut de Recerca Biomedica - IRB Lleida; Universitat de Lleida;
   University of British Columbia
RP Finlay, BB (corresponding author), Univ British Columbia, Dept Microbiol & Immunol, 2185 East Mall, Vancouver, BC V6T 1Z4, Canada.
EM bfinlay@msl.ubc.ca
RI Ayala, Maria Victoria/A-7391-2010
OI Ayala, Maria Victoria/0000-0002-1496-966X; Littlejohn,
   Paula/0000-0003-3252-7862; Creus-Cuadros, Anna/0000-0001-7737-6266
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NR 198
TC 78
Z9 81
U1 15
U2 93
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0016-5085
EI 1528-0012
J9 GASTROENTEROLOGY
JI Gastroenterology
PD JUN
PY 2022
VL 162
IS 7
BP 1858
EP +
DI 10.1053/j.gastro.2022.01.058
EA MAY 2022
PG 20
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 3H9IK
UT WOS:000832341900017
PM 35248539
OA hybrid
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Ding, YJ
   Li, GD
   Zhou, ZG
   Deng, T
AF Ding, Yujin
   Li, Guangdi
   Zhou, Zhiguang
   Deng, Tuo
TI Molecular mechanisms underlying hepatitis C virus infection-related
   diabetes
SO METABOLISM-CLINICAL AND EXPERIMENTAL
LA English
DT Article
DE Diabetes; insulin resistance; Hepatitis C virus; Islet beta-cell;
   microRNA
ID INSULIN-RECEPTOR SUBSTRATE-1; GENOME-WIDE ASSOCIATION; FATTY
   LIVER-DISEASE; CORE PROTEIN; SIGNALING PATHWAY; BETA-CELL; SERINE
   PHOSPHORYLATION; CIRCULATING MICRORNAS; METABOLIC SYNDROME; OXIDATIVE
   STRESS
AB Diabetes is a noncommunicable widespread disease that poses the risk of severe complications in patients, with certain complications being life-threatening. Hepatitis C is an infectious disease that mainly causes liver damage, which is also a profound threat to human health. Hepatitis C virus (HCV) infection has many extrahepatic manifestations, including diabetes. Multiple mechanisms facilitate the strong association between HCV and diabetes. HCV infection can affect the insulin signaling pathway in liver and pancreatic tissue and change the profiles of circulating microRNAs, which may further influence the occurrence and development of diabetes. This review describes how HCV infection causes diabetes and discusses the current research progress with respect to HCV infection-related diabetes. (c) 2021 Published by Elsevier Inc.
C1 [Ding, Yujin; Zhou, Zhiguang; Deng, Tuo] Cent South Univ, Natl Clin Res Ctr Metab Dis, Second Xiangya Hosp, 139 Middle Renmin Rd, Changsha 410011, Hunan, Peoples R China.
   [Ding, Yujin; Zhou, Zhiguang; Deng, Tuo] Cent South Univ, Dept Endocrinol & Metab, Second Xiangya Hosp, 139 Middle Renmin Rd, Changsha 410011, Hunan, Peoples R China.
   [Ding, Yujin; Zhou, Zhiguang; Deng, Tuo] Cent South Univ, Key Lab Diabet Immunol, Second Xiangya Hosp, Minist Educ, 139 Middle Renmin Rd, Changsha 410011, Hunan, Peoples R China.
   [Ding, Yujin; Zhou, Zhiguang; Deng, Tuo] Cent South Univ, Metab Syndrome Res Ctr, Second Xiangya Hosp, 139 Middle Renmin Rd, Changsha 410011, Hunan, Peoples R China.
   [Deng, Tuo] Cent South Univ, Clin Immunol Ctr, Second Xiangya Hosp, Changsha 410011, Hunan, Peoples R China.
   [Li, Guangdi] Cent South Univ, Hunan Prov Key Lab Clin Epidemiol, Xiangya Sch Publ Hlth, Changsha 410011, Hunan, Peoples R China.
C3 Central South University; Central South University; Central South
   University; Ministry of Education - China; Central South University;
   Central South University; Central South University
RP Deng, T (corresponding author), Cent South Univ, Natl Clin Res Ctr Metab Dis, Key Lab Diabet Immunol, Minist Educ,Dept Metab & Endocrinol, Changsha 410011, Hunan, Peoples R China.
EM dengtuo@csu.edu.cn
RI li, qing/JEF-9044-2023; Li, Guangdi/AAU-6951-2020
OI Li, Guangdi/0000-0001-8852-034X
FU National Key R&D Program of China [2020YFA0803604]; National Natural
   Science Foundation of China [81770868, 91742103, 31871324, 31571368];
   National Science and Technology Major Project [2020ZX0920128]; Science
   and Technology Innovation Program of Hunan Province [2020RC4009]; Hunan
   Youth Elite Project [2018RS3006]; Project of InnovationDriven Plan of
   Central South University [2020CX015]
FX This work was supported by grants from the National Key R&D Program of
   China (2020YFA0803604) , the National Natural Science Foundation of
   China (81770868, 91742103, 31871324, 31571368) , the National Science
   and Technology Major Project (2020ZX0920128) , the Science and
   Technology Innovation Program of Hunan Province (2020RC4009) , Hunan
   Youth Elite Project (2018RS3006) , and the Project of InnovationDriven
   Plan of Central South University (2020CX015) .
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NR 148
TC 9
Z9 9
U1 4
U2 31
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0026-0495
EI 1532-8600
J9 METABOLISM
JI Metab.-Clin. Exp.
PD AUG
PY 2021
VL 121
AR 154802
DI 10.1016/j.metabol.2021.154802
EA JUN 2021
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA TF4CY
UT WOS:000670664200001
PM 34090869
DA 2025-06-11
ER

PT J
AU Mao, FF
   Chen, T
   Zhao, Y
   Zhang, CQ
   Bai, B
   Zhao, SM
   Xu, ZK
   Shi, CH
AF Mao, Fengfeng
   Chen, Tao
   Zhao, Yong
   Zhang, Caiqin
   Bai, Bing
   Zhao, Shanmin
   Xu, Zhikai
   Shi, Changhong
TI Insulin resistance: A potential marker and risk factor for active
   tuberculosis?
SO MEDICAL HYPOTHESES
LA English
DT Article
ID MYCOBACTERIUM-TUBERCULOSIS; METABOLIC SYNDROME; MACROPHAGES; DISEASE;
   INFECTION; APOPTOSIS; PATHWAY; STRESS; RAT
AB Current tuberculosis control measures are focused on the prompt detection and treatment of active tuberculosis. Despite the measured success of this strategy, tuberculosis continues to be a public health issue of major significance around the world. This unwanted situation suggests the need to expand our control efforts by exploring specific markers for the disease. Insulin resistance is one such marker. Although insulin resistance has been implicated in various diseases, thus far, no attempt has been made to analyze what has proved to be a direct relationship between insulin resistance and Mycobacterium tuberculosis susceptibility. Several studies have shown the role of insulin not only in cellular metabolism but also, more importantly, in phagocytosis of M. tuberculosis. Therefore, we hypothesize that insulin resistance can be considered a potential risk factor for active M. tuberculosis infection. (C) 2011 Elsevier Ltd. All rights reserved.
C1 [Mao, Fengfeng; Zhao, Yong; Zhang, Caiqin; Bai, Bing; Zhao, Shanmin; Shi, Changhong] Fourth Mil Med Univ, Lab Anim Ctr, Xian 710032, Peoples R China.
   [Chen, Tao] Fourth Mil Med Univ, Dept Cardiac Surg, Xijing Hosp, Xian 710032, Peoples R China.
   [Xu, Zhikai] Fourth Mil Med Univ, Dept Microbiol, Sch Basic Med, Xian 710032, Peoples R China.
C3 Air Force Medical University; Air Force Medical University; Air Force
   Medical University
RP Shi, CH (corresponding author), Fourth Mil Med Univ, Lab Anim Ctr, 17 Changlexilu, Xian 710032, Peoples R China.
EM maoffeng@gmail.com; changhong@fmmu.edu.cn
OI Mao, Fengfeng/0000-0002-7288-5069
FU High Technology Research and Development Program of China (863 Program)
   [2008ZX10003-013-3]; National Natural Science Foundation of China
   [30972767]; Natural Science Foundation of Shaanxi Province, China
   [2007C224]
FX This work was supported by grants from the High Technology Research and
   Development Program of China (863 Program) (2008ZX10003-013-3) and the
   National Natural Science Foundation of China (No. 30972767) and the
   Natural Science Foundation of Shaanxi Province, China (No. 2007C224).
CR [Anonymous], 2009, WHOHTMTB2009411
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NR 35
TC 16
Z9 18
U1 1
U2 9
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0306-9877
EI 1532-2777
J9 MED HYPOTHESES
JI Med. Hypotheses
PD JUL
PY 2011
VL 77
IS 1
BP 66
EP 68
DI 10.1016/j.mehy.2011.03.025
PG 3
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 788FM
UT WOS:000292430800017
PM 21459520
DA 2025-06-11
ER

PT J
AU Imrie, H
   Abbas, A
   Kearney, M
AF Imrie, Helen
   Abbas, Afroze
   Kearney, Mark
TI Insulin resistance, lipotoxicity and endothelial dysfunction
SO BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
LA English
DT Review
DE Nitric oxide; Reactive oxygen species; Free fatty acid
ID NITRIC-OXIDE SYNTHASE; ACUTE CORONARY SYNDROME; MIDDLE-AGED MEN;
   OXIDATIVE STRESS; BLOOD-PRESSURE; METABOLIC SYNDROME; DIABETES-MELLITUS;
   HEART-DISEASE; OBESE HUMANS; FATTY-ACIDS
AB The number of people with the insulin-resistant conditions of type 2 diabetes mellitus (T2DM) and obesity has reached epidemic proportions worldwide. Eighty percent of people with T2DM will die from the complications of cardiovascular atherosclerosis. Insulin resistance is characterised by endothelial dysfunction, which is a pivotal step in the initiation/progression of atherosclerosis. A hallmark of endothelial dysfunction is an unfavourable imbalance between the bioavailability of the antiatherosclerotic signalling molecule nitric oxide (NO) and proatherosclerotic reactive oxygen species. In this review we discuss the mechanisms linking insulin resistance to endothelial dysfunction, with a particular emphasis on a potential role for a toxic effect of free fatty acids on endothelial cell homeostasis. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Imrie, Helen; Abbas, Afroze; Kearney, Mark] Leeds Multidisciplinary Cardiovasc Res Ctr, Div Cardiovasc & Diabet Res, LIGHT Labs, Leeds LS2 9JT, W Yorkshire, England.
C3 University of Leeds
RP Imrie, H (corresponding author), Leeds Multidisciplinary Cardiovasc Res Ctr, Div Cardiovasc & Diabet Res, LIGHT Labs, Clarendon Way, Leeds LS2 9JT, W Yorkshire, England.
EM h.imrie@leeds.ac.uk
FU British Heart Foundation
FX The studies described from the author's laboratory were supported by The
   British Heart Foundation.
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NR 83
TC 53
Z9 64
U1 0
U2 5
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1388-1981
EI 0006-3002
J9 BBA-MOL CELL BIOL L
JI Biochim. Biophys. Acta Mol. Cell Biol. Lipids
PD MAR
PY 2010
VL 1801
IS 3
SI SI
BP 320
EP 326
DI 10.1016/j.bbalip.2009.09.025
PG 7
WC Biochemistry & Molecular Biology; Biophysics; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Cell Biology
GA 568YT
UT WOS:000275563300016
PM 19818873
DA 2025-06-11
ER

PT J
AU Corry, DB
   Tuck, ML
AF Corry, Dalila B.
   Tuck, Michael L.
TI Uric acid and the vasculature
SO CURRENT HYPERTENSION REPORTS
LA English
DT Article
ID CORONARY-HEART-DISEASE; CARDIOVASCULAR RISK-FACTORS;
   ESSENTIAL-HYPERTENSION; XANTHINE-OXIDASE; NITRIC-OXIDE; ENDOTHELIAL
   DYSFUNCTION; CELL-PROLIFERATION; INSULIN-RESISTANCE; FOLLOW-UP;
   HYPERURICEMIA
AB Hyperuricemia is a frequent finding in diseases in which the clinical manifestations are thought to be secondary to a state of generalized vascular endothelial dysfunction and related to the cardiovascular disease present in conditions associated with the metabolic syndrome, such as hypertension or diabetes. Traditionally, uric acid has not been given an active role in the pathologic process underlying these conditions. However, there is now a growing body of experimental and clinical evidence that points to a mechanistic role for uric acid in cardiovascular disease. The mechanisms that are most often thought to link uric acid and endothelial dysfunction involve inflammation and generation of oxidative stress in the vasculature. These observations allowed new clinical applications and formulations of therapies, such as the introduction of xanthine oxidase inhibitors in the management of congestive heart failure.
C1 Olive View UCLA Med Ctr, Dept Med, Sylmar, CA 92342 USA.
C3 University of California System; University of California Los Angeles
RP Corry, DB (corresponding author), Olive View UCLA Med Ctr, Dept Med, 14445 Olive View Dr, Sylmar, CA 92342 USA.
EM dbcorry@ucla.edu
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NR 55
TC 37
Z9 44
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1522-6417
EI 1534-3111
J9 CURR HYPERTENS REP
JI Curr. Hypertens. Rep.
PD MAY
PY 2006
VL 8
IS 2
BP 116
EP 119
DI 10.1007/s11906-006-0006-y
PG 4
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 105BD
UT WOS:000242003400006
PM 16672143
DA 2025-06-11
ER

PT J
AU El Hayek, S
   Bitar, L
   Hamdar, LH
   Mirza, FG
   Daoud, G
AF El Hayek, Samer
   Bitar, Lynn
   Hamdar, Layal H.
   Mirza, Fadi G.
   Daoud, Georges
TI Poly Cystic Ovarian Syndrome: An Updated Overview
SO FRONTIERS IN PHYSIOLOGY
LA English
DT Review
DE PCOS; ovary; insulin; obesity; diabetes
ID IMPAIRED GLUCOSE-TOLERANCE; QUALITY-OF-LIFE; INSULIN SENSITIZER
   PIOGLITAZONE; REGULAR MENSTRUAL CYCLES; OMENTAL ADIPOSE-TISSUE; IN-VITRO
   FERTILIZATION; D-CHIRO-INOSITOL; POLYCYSTIC-OVARY; SYNDROME PCOS;
   METABOLIC SYNDROME
AB Poly Cystic Ovarian Syndrome (PCOS) is one of the most common metabolic and reproductive disorders among women of reproductive age. Women suffering from PCOS present with a constellation of symptoms associated with menstrual dysfunction and androgen excess, which significantly impacts their quality of life. They may be at increased risk of multiple morbidities, including obesity, insulin resistance, type II diabetes mellitus, cardiovascular disease (CVD), infertility, cancer, and psychological disorders. This review summarizes what the literature has so far provided from guidelines to diagnosis of PCOS. It will also present a general overview about the morbidities associated with this disease, specifically with its more severe classic form. Finally, the review will stress on the various aspects of treatment and screening recommendations currently used in the management of this condition.
C1 [El Hayek, Samer; Bitar, Lynn; Hamdar, Layal H.; Daoud, Georges] Amer Univ Beirut, Fac Med, Dept Anat Cell Biol & Physiol Sci, Beirut, Lebanon.
   [Mirza, Fadi G.] Amer Univ Beirut, Fac Med, Dept Obstet & Gynecol, Beirut, Lebanon.
   [Mirza, Fadi G.] Columbia Univ Coll Phys & Surg, Dept Obstet & Gynecol, New York, NY 10032 USA.
C3 American University of Beirut; American University of Beirut; Columbia
   University
RP Daoud, G (corresponding author), Amer Univ Beirut, Fac Med, Dept Anat Cell Biol & Physiol Sci, Beirut, Lebanon.; Mirza, FG (corresponding author), Amer Univ Beirut, Fac Med, Dept Obstet & Gynecol, Beirut, Lebanon.; Mirza, FG (corresponding author), Columbia Univ Coll Phys & Surg, Dept Obstet & Gynecol, New York, NY 10032 USA.
EM fmirza@aub.edu.lb; gd12@aub.edu.lb
OI Daoud, Georges/0000-0001-8043-3882; El Hayek, Samer/0000-0002-7975-6104;
   Bitar, Lynn/0000-0002-7347-6099
FU Medical Practice Plan, American University of Beirut Medical center
   (MPP-AUBMC)
FX This work was supported by the Medical Practice Plan, American
   University of Beirut Medical center (MPP-AUBMC).
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NR 186
TC 163
Z9 184
U1 1
U2 47
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-042X
J9 FRONT PHYSIOL
JI Front. Physiol.
PD APR 5
PY 2016
VL 7
AR 124
DI 10.3389/fphys.2016.00124
PG 15
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA DI2KG
UT WOS:000373323900002
PM 27092084
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Ntanasis-Stathopoulos, J
   Tzanninis, JG
   Philippou, A
   Koutsilieris, M
AF Ntanasis-Stathopoulos, J.
   Tzanninis, J-G.
   Philippou, A.
   Koutsilieris, M.
TI Epigenetic regulation on gene expression induced by physical exercise
SO JOURNAL OF MUSCULOSKELETAL & NEURONAL INTERACTIONS
LA English
DT Review
DE Acetylation; DNA Methylation; Gene Silencing; Histone Modification;
   microRNAs
ID NF-KAPPA-B; SKELETAL-MUSCLE FIBERS; HEAVY-CHAIN GENES; NEUROTROPHIC
   FACTOR; ENDURANCE EXERCISE; AEROBIC EXERCISE; TRANSCRIPTION FACTOR;
   HISTONE ACETYLATION; DNA METHYLATION; INFLAMMATORY CYTOKINES
AB It is well established that physical exercise modulates the function of many physiological systems, such as the musculoskeletal, the cardiovascular and the nervous system, by inducing various adaptations to the increased mechanical load and/or metabolic stress of exercise. Many of these changes occur through epigenetic alterations to DNA, such as histone modifications, DNA methylations, expression of microRNAs and changes of the chromatin structure. All these epigenetic alterations may have clinical relevance, thus playing an important role in the prevention and confrontation of neurophysiological disorders, metabolic syndrome, cardiovascular diseases and cancer. Herein we review the known epigenetic modifications induced by physical exercise in various physiological systems and pathologies, and discuss their potential clinical implications.
C1 [Ntanasis-Stathopoulos, J.; Tzanninis, J-G.; Philippou, A.; Koutsilieris, M.] Natl & Kapodistrian Univ Athens, Sch Med, Dept Expt Physiol, Athens 11527, Greece.
C3 National & Kapodistrian University of Athens; Athens Medical School
RP Koutsilieris, M (corresponding author), Natl & Kapodistrian Univ Athens, Sch Med, Dept Expt Physiol, 75 Micras Asias, Athens 11527, Greece.
EM mkoutsil@med.uoa.gr
RI Koutsilieris, Michael/AAD-3648-2019; Philippou, Anastassios/H-2748-2019
OI Ntanasis-Stathopoulos, Ioannis/0000-0002-6328-9783; Philippou,
   Anastassios/0000-0003-0047-3003
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NR 177
TC 102
Z9 113
U1 0
U2 41
PU JMNI
PI NAFPLION
PA 7 SPILIADOU SQ, NAFPLION, 21 100, GREECE
SN 1108-7161
J9 J MUSCULOSKEL NEURON
JI J. Musculoskelet. Neuronal Interact.
PD JUN
PY 2013
VL 13
IS 2
BP 133
EP 146
PG 14
WC Neurosciences; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Physiology
GA 176TI
UT WOS:000321327400002
PM 23728100
DA 2025-06-11
ER

PT J
AU Tsutsui, M
   Nakata, S
   Shimokawa, H
   Otsuji, Y
   Yanagihara, N
AF Tsutsui, Masato
   Nakata, Sei
   Shimokawa, Hiroaki
   Otsuji, Yutaka
   Yanagihara, Nobuyuki
TI Spontaneous Myocardial Infarction and Nitric Oxide Synthase
SO TRENDS IN CARDIOVASCULAR MEDICINE
LA English
DT Review
ID CORONARY-ARTERY-DISEASE; VASCULAR SMOOTH-MUSCLE; ARGININE METHYL-ESTER;
   DEFICIENT MICE; MOLECULAR-MECHANISMS; INSULIN-RESISTANCE; METABOLIC
   SYNDROME; OXIDATIVE STRESS; ENDOTHELIUM; DYSFUNCTION
AB Myocardial infarction (MI) is caused by coronary atherosclerosis and/or arteriosclerosis. Because endothelial nitric oxide synthase (eNOS) exerts powerful antiatherosclerotic/antiarteriosclerotic effects, it is speculated that blockade of eNOS activity might result in MI. However, neither genetic disruption of eNOS nor pharmacologic inhibition of eNOS activity induces MI in animals. On the other hand, intriguingly, genetic disruption of all three nitric oxide synthase (NOS) isoforms (neuronal NOS, inducible NOS, and eNOS) spontaneously caused MI accompanied by multiple cardiovascular risk factors of metabolic origin in mice. This is the first in vivo demonstration showing that the defective NOS system is involved in the pathogenesis of spontaneous MI. Based on the evidence, this review summarizes our current knowledge of spontaneous MI and NOS. (Trends Cardiovasc Med 2008; 18:275-279) (C) 2008, Elsevier Inc.
C1 [Tsutsui, Masato; Yanagihara, Nobuyuki] Univ Occupat & Environm Hlth, Dept Pharmacol, Sch Med, Kitakyushu, Fukuoka 8078555, Japan.
   [Nakata, Sei; Otsuji, Yutaka] Univ Occupat & Environm Hlth, Dept Internal Med 2, Sch Med, Kitakyushu, Fukuoka 8078555, Japan.
   [Shimokawa, Hiroaki] Tohoku Univ, Grad Sch Med, Dept Cardiovasc Med, Sendai, Miyagi 9808574, Japan.
C3 University of Occupational & Environmental Health - Japan; University of
   Occupational & Environmental Health - Japan; Tohoku University
RP Tsutsui, M (corresponding author), Univ Occupat & Environm Hlth, Dept Pharmacol, Sch Med, Kitakyushu, Fukuoka 8078555, Japan.
EM mt2498@med.uoeh-u.ac.jp
OI Shimokawa, Hiroaki/0000-0001-7534-4826
FU Scientific Research [20390074, 16209027, 166591192, 17390071, 14570096];
   Ministry of Education, Culture, Sports, Science and Technology, Tokyo,
   Japan [16650097, 16659209]; Yamanouchi Foundation for Research on
   Metabolic Disorders; Research Foundation for Treatment of Metabolic
   Abnormalities; Sankyo Pharmaceutical Co; Japan Heart. Foundation;
   Research on Arteriosclerosis Update; Smoking Research Foundation;
   University of Occupational and Environmental Health for Advanced
   Research; Grants-in-Aid for Scientific Research [16650097, 16659209]
   Funding Source: KAKEN
FX The authors' work presented in this article was supported in part by the
   Grants-in-Aid for Scientific Research (20390074, 16209027, 166591192,
   17390071, 14570096) and the Grants-in-Aid for Exploratory Research
   (16650097, 16659209) from the Ministry of Education, Culture, Sports,
   Science and Technology, Tokyo, Japan, and the Japanese Ministry of
   Health, Labor, and Welfare (Tokyo, Japan), and by grants from the
   Yamanouchi Foundation for Research on Metabolic Disorders, the Research
   Foundation for Treatment of Metabolic Abnormalities (Osaka, Japan), the
   Sankyo Pharmaceutical Co (Tokyo, Japan), the Japan Heart. Foundation
   Grant. for Research on Arteriosclerosis Update (Tokyo, Japan), the
   Smoking Research Foundation (Tokyo, Japan), and the University of
   Occupational and Environmental Health for Advanced Research (Kitakyushu,
   Japan).
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NR 35
TC 19
Z9 23
U1 1
U2 10
PU ELSEVIER SCIENCE LONDON
PI LONDON
PA 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND
SN 1050-1738
J9 TRENDS CARDIOVAS MED
JI Trends Cardiovasc. Med.
PD NOV
PY 2008
VL 18
IS 8
BP 275
EP 279
AR PII S1050-1738(08)00140-0
DI 10.1016/j.tcm.2008.12.002
PG 5
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 434HA
UT WOS:000265264600001
PM 19345314
DA 2025-06-11
ER

PT J
AU Sigdel, S
   Udoh, G
   Albalawy, R
   Wang, JJ
AF Sigdel, Smara
   Udoh, Gideon
   Albalawy, Rakan
   Wang, Jinju
TI Perivascular Adipose Tissue and Perivascular Adipose Tissue-Derived
   Extracellular Vesicles: New Insights in Vascular Disease
SO CELLS
LA English
DT Review
DE perivascular adipose tissue; extracellular vesicles; vascular diseases;
   obesity; diabetes
ID RISK-FACTORS; ENDOTHELIAL DYSFUNCTION; OXIDATIVE STRESS; PROGENITOR
   CELLS; NITRIC-OXIDE; IN-VITRO; OBESITY; ADIPONECTIN; EXOSOMES; FAT
AB Perivascular adipose tissue (PVAT) is a special deposit of fat tissue surrounding the vasculature. Previous studies suggest that PVAT modulates the vasculature function in physiological conditions and is implicated in the pathogenesis of vascular diseases. Understanding how PVAT influences vasculature function and vascular disease progression is important. Extracellular vesicles (EVs) are novel mediators of intercellular communication. EVs encapsulate molecular cargo such as proteins, lipids, and nucleic acids. EVs can influence cellular functions by transferring the carried bioactive molecules. Emerging evidence indicates that PVAT-derived EVs play an important role in vascular functions under health and disease conditions. This review will focus on the roles of PVAT and PVAT-EVs in obesity, diabetic, and metabolic syndrome-related vascular diseases, offering novel insights into therapeutic targets for vascular diseases.
C1 [Sigdel, Smara; Udoh, Gideon; Wang, Jinju] Marshall Univ, Joan C Edwards Sch Med, Dept Biomed Sci, Huntington, WV 25755 USA.
   [Albalawy, Rakan] Marshall Univ, Joan C Edwards Sch Med, Dept Internal Med, Huntington, WV 25755 USA.
C3 Marshall University; Marshall University
RP Wang, JJ (corresponding author), Marshall Univ, Joan C Edwards Sch Med, Dept Biomed Sci, Huntington, WV 25755 USA.
EM sigdels@marshall.edu; udoh3@marshall.edu; albalawy@marshall.edu;
   wangjin@marshall.edu
OI Sigdel, Smara/0009-0009-4466-0127; Wang, Jinju/0000-0003-1210-7676
FU National Institute of General Medical Sciences [U54GM104942]; NASA West
   Virginia Space Grant Consortium [80NSSC20M0055]; American Heart
   Association (AHA) Career Development Award [935826]; Transformational
   Project Award [24TPA1291189]; American Heart Association (AHA) [935826]
   Funding Source: American Heart Association (AHA)
FX This work was partially supported by the pilot grant (J.W.) of the
   National Institute of General Medical Sciences (U54GM104942), the NASA
   West Virginia Space Grant Consortium (80NSSC20M0055; S.S.), and the
   American Heart Association (AHA) Career Development Award (935826; J.W.)
   and Transformational Project Award (24TPA1291189; J.W.).
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NR 146
TC 2
Z9 2
U1 1
U2 1
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2073-4409
J9 CELLS-BASEL
JI Cells
PD AUG
PY 2024
VL 13
IS 16
AR 1309
DI 10.3390/cells13161309
PG 19
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA E7V2H
UT WOS:001305037200001
PM 39195199
OA gold
DA 2025-06-11
ER

PT J
AU Shimizu, K
   Takahashi, M
   Sato, S
   Saiki, A
   Nagayama, D
   Harada, M
   Miyazaki, C
   Takahara, A
   Shirai, K
AF Shimizu, Kazuhiro
   Takahashi, Mao
   Sato, Shuji
   Saiki, Atsuhito
   Nagayama, Daiji
   Harada, Masashi
   Miyazaki, Chikao
   Takahara, Akira
   Shirai, Kohji
TI Rapid Rise of Cardio-Ankle Vascular Index May Be a Trigger of
   Cerebro-Cardiovascular Events: Proposal of Smooth Muscle Cell
   Contraction Theory for Plaque Rupture
SO VASCULAR HEALTH AND RISK MANAGEMENT
LA English
DT Article
DE arterial stiffness; atherosclerosis; smooth muscle cell contraction;
   CAVI
ID PULSE-WAVE VELOCITY; EAST JAPAN EARTHQUAKE; ARTERIAL STIFFNESS;
   METABOLIC SYNDROME; CORONARY SPASM; VASA VASORUM; STRESS; HEART; WALL;
   ATHEROSCLEROSIS
AB Cardiovascular diseases have been recognized as the main cause of death all over the world. Recently, the established cardio-ankle vascular index (CAVI) has become known as an index of arterial stiffness of the arterial tree from the origin of the aorta to the ankle. CAVI reflects the progress of arteriosclerosis, and a rapid rise in CAVI indicates arterial smooth muscle cell contraction. Considering the vasculature of the atheroma where vasa vasorum penetrates the smooth muscle cell layer and supplies blood to the intimal atheromatous lesion, a rapid rise of CAVI means "choked" atheroma. Thus, we proposed a "smooth muscle cell contraction" hypothesis of plaque rupture.
C1 [Shimizu, Kazuhiro; Takahashi, Mao; Sato, Shuji; Saiki, Atsuhito; Nagayama, Daiji; Shirai, Kohji] Toho Univ, Dept Internal Med, Sakura Med Ctr, 561-4 Shimoshizu, Sakura, Chiba 2858741, Japan.
   [Harada, Masashi; Miyazaki, Chikao] Toho Univ, Dept Neurosurg, Omori Med Ctr, Omori, Tokyo, Japan.
   [Takahara, Akira] Toho Univ, Fac Pharmaceut Sci, Dept Pharmacol & Therapeut, Funabashi, Chiba, Japan.
C3 Toho University; Toho University; Toho University
RP Shirai, K (corresponding author), Toho Univ, Dept Internal Med, Sakura Med Ctr, 561-4 Shimoshizu, Sakura, Chiba 2858741, Japan.
EM kshirai@kb3.so-net.ne.jp
RI Takahara, Akira/GVT-1863-2022; Nagayama, Daiji/AAS-4216-2020
OI Sato, Shuji/0000-0002-6386-8670; yong shan, da er/0000-0001-6119-8012;
   Kazuhiro, Shimizu/0000-0001-9896-0939
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NR 72
TC 10
Z9 11
U1 0
U2 1
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1176-6344
EI 1178-2048
J9 VASC HEALTH RISK MAN
JI Vasc. Health Risk Manag.
PY 2021
VL 17
BP 37
EP 47
DI 10.2147/VHRM.S290841
PG 11
WC Peripheral Vascular Disease
WE Emerging Sources Citation Index (ESCI)
SC Cardiovascular System & Cardiology
GA QM5XK
UT WOS:000621851800001
PM 33603388
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Brietzke, E
   Mansur, RB
   Zugman, A
   Carvalho, AF
   Macêdo, DS
   Cha, DS
   Abílio, VC
   McIntyre, RS
AF Brietzke, Elisa
   Mansur, Rodrigo B.
   Zugman, Andre
   Carvalho, Andre F.
   Macedo, Danielle S.
   Cha, Danielle S.
   Abilio, Vanessa C.
   McIntyre, Roger S.
TI Is there a role for curcumin in the treatment of bipolar disorder?
SO MEDICAL HYPOTHESES
LA English
DT Article
ID ANTIDEPRESSANT-LIKE ACTIVITY; FAMILY-BASED ASSOCIATION; NEUROTROPHIC
   FACTOR GENE; PLACEBO-CONTROLLED TRIAL; HUMAN GALL-BLADDER;
   CORTICAL-NEURONS; MOOD DISORDERS; DOUBLE-BLIND; METABOLIC SYNDROME;
   OXIDATIVE STRESS
AB Curcumin is a polyphenolic nonflavonoid compound extracted from the rhizome of turmeric (Curcuma longa), a plant commonly used in Indian and Chinese traditional medicine to treat rheumatism, cough, inflammation and wounds. Curcumin putative targets, known based on studies of diverse central nervous system disorders other than bipolar disorders (BD) include several proteins currently implicated in the pathophysiology of BD. These targets include, but are not limited to, transcription factors activated by environmental stressors and pro-inflammatory cytoldnes, protein kinases (PICA, PKC), enzymes, growth factors, inflammatory mediators, and anti-apoptotic proteins (Bcl-XL). Herein, we review previous studies on the anti-inflammatory and anti-oxidant properties of curcumin and discuss its therapeutic potential in BD. (C) 2013 Elsevier Ltd. All rights reserved.
C1 [Brietzke, Elisa; Mansur, Rodrigo B.; Zugman, Andre] Univ Fed Sao Paulo, Dept Psychiat, Sao Paulo, Brazil.
   [Carvalho, Andre F.] Univ Fed Ceara, Dept Clin Med, Fortaleza, Ceara, Brazil.
   [Carvalho, Andre F.] Univ Fed Ceara, Psychiat Res Grp, Fortaleza, Ceara, Brazil.
   [Macedo, Danielle S.] Univ Fed Ceara, Neuropharmacol Lab, Dept Physiol & Pharmacol, Fortaleza, Ceara, Brazil.
   [Abilio, Vanessa C.] Univ Fed Sao Paulo, Dept Pharmacol, Sao Paulo, Brazil.
   [Cha, Danielle S.; McIntyre, Roger S.] Univ Toronto, MDPU, Toronto, ON, Canada.
C3 Universidade Federal de Sao Paulo (UNIFESP); Universidade Federal do
   Ceara; Universidade Federal do Ceara; Universidade Federal do Ceara;
   Universidade Federal de Sao Paulo (UNIFESP); University of Toronto
RP Zugman, A (corresponding author), Rua Pedro de Toledo 669 3rd Floor, Sao Paulo, Brazil.
EM andre.zugman@gmail.com
RI Zugman, Andre/W-8157-2019; Carvalho, Andre/AEZ-4001-2022; Abilio,
   Vanessa/E-3823-2013; McIntyre, Roger/AAU-1000-2020; Mansur,
   Rodrigo/N-7131-2019; Brietzke, Elisa/G-9559-2012; Macedo,
   Danielle/E-3424-2014
OI Zugman, Andre/0000-0002-6126-7759; Abilio, Vanessa
   C./0000-0002-4967-4765; Macedo, Danielle/0000-0001-8980-9970
FU FAPESP (Brazil); CNPq (Brazil)
FX This work has been supported by FAPESP (Brazil) and CNPq (Brazil).
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NR 121
TC 15
Z9 19
U1 0
U2 24
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0306-9877
EI 1532-2777
J9 MED HYPOTHESES
JI Med. Hypotheses
PD MAY
PY 2013
VL 80
IS 5
BP 606
EP 612
DI 10.1016/j.mehy.2013.02.001
PG 7
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 131LK
UT WOS:000317995000022
PM 23484676
OA hybrid
DA 2025-06-11
ER

PT J
AU Cárdenas-Escudero, J
   Mármol-Rojas, C
   Pintor, SE
   Galán-Madruga, D
   Cáceres, JO
AF Cardenas-Escudero, J.
   Marmol-Rojas, C.
   Pintor, S. Escribano
   Galan-Madruga, D.
   Caceres, J. O.
TI Honey polyphenols: regulators of human microbiota and health
SO FOOD & FUNCTION
LA English
DT Review
ID LACTIC-ACID BACTERIA; GUT MICROBIOTA; PROSTAGLANDIN E-2;
   ANTIINFLAMMATORY ACTIVITY; LIQUID-CHROMATOGRAPHY; DIETARY POLYPHENOLS;
   INSULIN-RESISTANCE; ALPHA-GLUCOSIDASE; OXIDATIVE STRESS; MIGHT
   CONTRIBUTE
AB A comprehensive review of research over the last decade was conducted to carry out this work. The main objective of this work is to present relevant evidence of the effect of honey intake on the human intestinal microbiota and its relationship with the improvement of various chronic diseases, such as cirrhosis, metabolic syndrome, diabetes, and obesity, among others. Therefore, this work focuses on the health-improving honey dietary supplementation implications associated with specific changes in the human microbiota and their biochemical mechanisms to enhance the proliferation of beneficial microorganisms and the inhibition of pathogenic microorganisms. Consumption of honey polyphenols significantly improves people's health conditions, especially in patients with chronic disease. Hence, honey intake unequivocally constitutes an alternative way to enhance health and could be used to prevent some relevant chronic diseases.
C1 [Cardenas-Escudero, J.; Marmol-Rojas, C.; Pintor, S. Escribano; Caceres, J. O.] Univ Complutense Madrid, Fac Chem, Dept Analyt Chem, Laser Chem Res Grp, Plaza Ciencias 1, Madrid 28040, Spain.
   [Galan-Madruga, D.] Carlos III Hlth Inst, Natl Ctr Environm Hlth, Ctra Majadahonda Pozuelo Km 2-2, Madrid 28220, Spain.
   [Cardenas-Escudero, J.] Univ Panama, FCNET, Analyt Chem Dept, Manuel E Batista & Jose De Fabrega Av,Ciudad Univ, Panama City 3366 4, Panama.
C3 Complutense University of Madrid; Instituto de Salud Carlos III; Centro
   Nacional de Sanidad Ambiental (CNSA); Universidad de Panama
RP Cáceres, JO (corresponding author), Univ Complutense Madrid, Fac Chem, Dept Analyt Chem, Laser Chem Res Grp, Plaza Ciencias 1, Madrid 28040, Spain.
RI Cárdenas-Escudero, Jafet/GYU-2070-2022; Galan, David/H-8777-2015
OI Cardenas-Escudero, Jafet/0000-0001-5589-9226; Galan,
   David/0000-0002-7890-4611; Caceres, Jorge/0000-0003-4801-4172
FU Universidad de Panama; Instituto para la Formacion y Aprovechamiento de
   los Recursos Humanos de Panama (IFARHU)
FX The authors gratefully acknowledge the facilities and material and
   instrumental resources of the Complutense University of Madrid. One of
   us (J. C. E) acknowledges to Universidad de Panama and Instituto para la
   Formacion y Aprovechamiento de los Recursos Humanos de Panama (IFARHU)
   for financing his doctoral studies.
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NR 208
TC 6
Z9 6
U1 4
U2 51
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PD JAN 23
PY 2023
VL 14
IS 2
BP 602
EP 620
DI 10.1039/d2fo02715a
EA DEC 2022
PG 19
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA 7X0VH
UT WOS:000901002700001
PM 36541681
DA 2025-06-11
ER

PT J
AU Bae, M
   Ahmed, K
   Yim, JE
AF Bae, Minkyung
   Ahmed, Kainat
   Yim, Jung-Eun
TI Beneficial Effects of Taurine on Metabolic Parameters in Animals and
   Humans
SO JOURNAL OF OBESITY & METABOLIC SYNDROME
LA English
DT Review
DE Taurine; Metabolic syndrome; Obesity; Dyslipidemia; Hypertension;
   Diabetes mellitus
ID KAPPA-B-ALPHA; DIABETIC COMPLICATIONS; MALNOURISHED MICE; OXIDATIVE
   STRESS; ADIPOSE-TISSUE; BLOOD-PRESSURE; HEART-DISEASE; SUPPLEMENTATION;
   INSULIN; RATS
AB Taurine (2-aminoethanesulfonic acid) is a non-essential amino acid mainly obtained through diet in humans. Despite the lack of research on the health effects of taurine in animals and humans, it is widely used as a dietary supplement. Evidence from human and animal studies indicates that taurine is involved in conjugation of bile acids and regulation of blood pressure and has anti-oxidative, anti-inflammatory, and anti-obesogenic properties. Taurine can benefit both human and non-human animal health in multiple ways. However, few interventional and epidemiological studies regarding the beneficial impacts of taurine in humans and other animals have been conducted. Here, we review the evidence from animal and human studies showing that taurine protects against dyslipidemia, obesity, hypertension, and diabetes mellitus.
C1 [Bae, Minkyung; Yim, Jung-Eun] Changwon Natl Univ, Dept Food & Nutr, 20 Changwondaehak Ro, Chang Won 51140, South Korea.
   [Bae, Minkyung; Ahmed, Kainat; Yim, Jung-Eun] Changwon Natl Univ, BK21, Interdisciplinary Program Senior Human Ecol, Chang Won, South Korea.
C3 Changwon National University; Changwon National University
RP Yim, JE (corresponding author), Changwon Natl Univ, Dept Food & Nutr, 20 Changwondaehak Ro, Chang Won 51140, South Korea.
EM jeyim@changwon.ac.kr
RI Yim, Jung-Eun/AAU-9517-2020; Bae, Minkyung/AAQ-7311-2021
OI AHMED, KAINAT/0000-0002-5603-8935; Yim, Jung-Eun/0000-0001-8344-1386
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NR 85
TC 19
Z9 19
U1 4
U2 34
PU KOREAN SOC STUDY OBESITY
PI SEOUL
PA RENAISSANCE TOWER, 1010  14 MALLIJAE-RO, MAPO-GU, SEOUL, 04195, SOUTH
   KOREA
SN 2508-6235
EI 2508-7576
J9 J OBES METAB SYNDR
JI J. Obes. Metab. Syndr.
PD JUN
PY 2022
VL 31
IS 2
BP 134
EP 146
DI 10.7570/jomes21088
PG 13
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA 2T3RQ
UT WOS:000822396500004
PM 35670160
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Hudspeth, B
AF Hudspeth, Brooke
TI The Burden of Cardiovascular Disease in Patients With Diabetes
SO AMERICAN JOURNAL OF MANAGED CARE
LA English
DT Article
ID CORONARY-HEART-DISEASE; RISK-FACTORS; BLOOD-PRESSURE; FOLLOW-UP;
   MULTIFACTORIAL INTERVENTION; ATHEROSCLEROSIS RISK; METABOLIC SYNDROME;
   OXIDATIVE STRESS; GLYCEMIC CONTROL; CLINICAL-TRIAL
AB Adults with type 2 diabetes (T2D) have a 2-to-4-fold higher risk for cardiovascular morbidity and mortality than adults without diabetes, according to the American Heart Association (AHA). Furthermore, the AHA deems diabetes to be "1 of the 7 major controllable risk factors for cardiovascular disease (CVD)." Lack of glycemic control may lead to nerve and cardiac conduction impairments and CVD. However, glycemic control is not the only risk factor. Additional risk factors for CVD in T2D include hypertension, dyslipidemia, obesity, lack of physical activity, and smoking. Patients with T2D are also more likely to have risk factors that increase atherosclerotic cardiovascular disease (ASCVD) risk, including hypertension, dyslipidemia, and obesity. Control of these risk factors, as well as understanding the link between hyperglycemia and cardiovascular risk, is essential for the optimal management of T2D.
C1 [Hudspeth, Brooke] Univ Kentucky, Coll Pharm, Lexington, KY 40506 USA.
C3 University of Kentucky
RP Hudspeth, B (corresponding author), Univ Kentucky, Coll Pharm, Lexington, KY 40506 USA.
EM brooke.hudspeth@uky.edu
FU Boehringer Ingelheim Pharmaceuticals, Inc.; Lilly USA, LLC
FX This activity is supported by an independent educational grant from
   Boehringer Ingelheim Pharmaceuticals, Inc. and Lilly USA, LLC.
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NR 70
TC 19
Z9 20
U1 0
U2 3
PU MANAGED CARE & HEALTHCARE COMMUNICATIONS LLC
PI PLAINSBORO
PA 666 PLAINSBORO RD, STE 300, PLAINSBORO, NJ 08536 USA
SN 1088-0224
J9 AM J MANAG CARE
JI Am. J. Manag. Care
PD AUG
PY 2018
VL 24
IS 13
SU S
BP S268
EP S272
PG 5
WC Health Care Sciences & Services; Health Policy & Services; Medicine,
   General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services; General & Internal Medicine
GA GX1UR
UT WOS:000447504500001
PM 30160393
DA 2025-06-11
ER

PT J
AU Obradovic, MM
   Trpkovic, A
   Bajic, V
   Soskic, S
   Jovanovic, A
   Stanimirovic, J
   Panic, M
   Isenovic, ER
AF Obradovic, Milan M.
   Trpkovic, Andreja
   Bajic, Vladan
   Soskic, Sanja
   Jovanovic, Aleksandra
   Stanimirovic, Julijana
   Panic, Milos
   Isenovic, Esma R.
TI Interrelatedness between C-reactive protein and oxidized low-density
   lipoprotein
SO CLINICAL CHEMISTRY AND LABORATORY MEDICINE
LA English
DT Review
DE C-reactive protein (CRP); C-reactive protein and oxidized low-density
   lipoprotein (OxLDL) interrelatedness; oxidized low-density lipoprotein
ID CORONARY-HEART-DISEASE; MIDDLE-AGED MEN; AORTIC ENDOTHELIAL-CELLS;
   CLINICAL-SIGNIFICANCE; OXIDATIVE STRESS; CARDIOVASCULAR-DISEASE;
   METABOLIC SYNDROME; STATIN THERAPY; LDL; RISK
AB C-reactive protein (CRP) is a marker of inflammation. Atherosclerosis is now recognized as inflammatory disease, and it seems that CRP directly contributes to atherogenesis. Oxidation of low-density lipoprotein (LDL) molecule increases the uptake of lipid products by macrophages leading to cholesterol accumulation and subsequent foam cell formation. The elevated levels of high sensitivity CRP (hsCRP) and oxidized LDL (OxLDL) in the blood were found to be associated with cardiovascular diseases (CVD). In this review, we highlighted the evidence that CRP and OxLDL are involved in interrelated (patho) physiological pathways. The findings on association between hsCRP and OxLDL in the clinical setting will be also summarized.
C1 [Obradovic, Milan M.; Trpkovic, Andreja; Bajic, Vladan; Soskic, Sanja; Jovanovic, Aleksandra; Stanimirovic, Julijana; Isenovic, Esma R.] Univ Belgrade, Vinca Inst Nucl Sci, Res Lab Radiobiol & Mol Genet, Belgrade 11000, Serbia.
   [Isenovic, Esma R.] Clin Hosp Ctr Zemun, Dept Cardiol, Zemun, Serbia.
C3 University of Belgrade
RP Obradovic, MM (corresponding author), Univ Belgrade, Vinca Inst Nucl Sci, Res Lab Radiobiol & Mol Genet, POB 522, Belgrade 11000, Serbia.
EM obradovicmilan@hotmail.com
RI Isenovic, Esma/D-3017-2009; Stanimirovic, Julijana/LPQ-7867-2024;
   Obradovic, Milan/AGN-1229-2022; Jovanovic Galovic,
   Aleksandra/HHC-5130-2022; Bajic, Vladan/JWO-5390-2024
OI Bajic, Vladan/0000-0002-2333-8245; Isenovic, Esma/0000-0002-0012-2636;
   Jovanovic, Aleksandra/0000-0001-8809-8951; Soskic,
   Sanja/0000-0002-9482-6940; Stanimirovic, Julijana/0000-0002-0929-3482;
   Obradovic, Milan/0000-0002-4769-2652
FU Ministry of Education and Science, Republic of Serbia [173033]
FX This work was supported by grant funded by the Ministry of Education and
   Science, Republic of Serbia, No. 173033 (to E. R. I.).
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NR 88
TC 18
Z9 20
U1 0
U2 9
PU WALTER DE GRUYTER GMBH
PI BERLIN
PA GENTHINER STRASSE 13, D-10785 BERLIN, GERMANY
SN 1434-6621
EI 1437-4331
J9 CLIN CHEM LAB MED
JI Clin. Chem. Lab. Med.
PD JAN
PY 2015
VL 53
IS 1
BP 29
EP 34
DI 10.1515/cclm-2014-0590
PG 6
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA AW0ZX
UT WOS:000346021000010
PM 25010779
DA 2025-06-11
ER

PT J
AU Marosi, K
   Mattson, MP
AF Marosi, Krisztina
   Mattson, Mark P.
TI BDNF mediates adaptive brain and body responses to energetic challenges
SO TRENDS IN ENDOCRINOLOGY AND METABOLISM
LA English
DT Review
DE Alzheimer's disease; BDNF; diabetes; exercise; glucocorticoid; insulin
   resistance; learning and memory; obesity
ID NEUROTROPHIC FACTOR BDNF; DOPAMINERGIC-NEURONS; SYNAPTIC PLASTICITY;
   CALORIE RESTRICTION; DIETARY RESTRICTION; LOCOMOTOR-ACTIVITY;
   PHYSICAL-EXERCISE; HIPPOCAMPAL BDNF; STIMULATION; RECEPTOR
AB Emerging findings suggest that brain-derived neurotrophic factor (BDNF) serves widespread roles in regulating energy homeostasis by controlling patterns of feeding and physical activity, and by modulating glucose metabolism in peripheral tissues. BDNF mediates the beneficial effects of energetic challenges such as vigorous exercise and fasting on cognition, mood, cardiovascular function, and on peripheral metabolism. By stimulating glucose transport and mitochondria! biogenesis BDNF bolsters cellular bioenergetics and protects neurons against injury and disease. By acting in the brain and periphery, BDNF increases insulin sensitivity and parasympathetic tone. Genetic factors, a 'couch potato' lifestyle, and chronic stress impair BDNF signaling, and this may contribute to the pathogenesis of metabolic syndrome. Novel BDNF-focused interventions are being developed for obesity, diabetes, and neurological disorders.
C1 [Marosi, Krisztina; Mattson, Mark P.] NIA, Lab Neurosci, Intramural Res Program, Baltimore, MD 21224 USA.
   [Mattson, Mark P.] Johns Hopkins Univ, Dept Neurosci, Sch Med, Baltimore, MD 21205 USA.
C3 National Institutes of Health (NIH) - USA; NIH National Institute on
   Aging (NIA); Johns Hopkins University
RP Mattson, MP (corresponding author), NIA, Lab Neurosci, Intramural Res Program, Baltimore, MD 21224 USA.
EM mark.mattson@nih.gov
RI Mattson, Mark/F-6038-2012
FU National Institute on Aging
FX This work was supported by the intramural research program of the
   National Institute on Aging. We thank KC (Kristen) Alexander for
   preparing the illustrations for Figures 1 and 2.
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NR 97
TC 415
Z9 461
U1 7
U2 160
PU CELL PRESS
PI CAMBRIDGE
PA 50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA
SN 1043-2760
EI 1879-3061
J9 TRENDS ENDOCRIN MET
JI Trends Endocrinol. Metab.
PD FEB
PY 2014
VL 25
IS 2
BP 89
EP 98
DI 10.1016/j.tem.2013.10.006
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA AB3HA
UT WOS:000331680700005
PM 24361004
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Sabio, G
   Davis, RJ
AF Sabio, Guadalupe
   Davis, Roger J.
TI cJun NH2-terminal kinase 1 (JNK1): roles in metabolic
   regulation of insulin resistance
SO TRENDS IN BIOCHEMICAL SCIENCES
LA English
DT Review
ID ENDOPLASMIC-RETICULUM STRESS; SIGNAL-TRANSDUCTION PATHWAY;
   NECROSIS-FACTOR-ALPHA; IN-VIVO; RECEPTOR SUBSTRATE-1; SKELETAL-MUSCLE;
   ADIPOSE-TISSUE; INTERLEUKIN-6 DOES/DOES; GLUCOSE-HOMEOSTASIS;
   THERAPEUTIC TARGET
AB The cJun NH2-terminal kinase isoform JNK1 is implicated in the mechanism of obesity-induced insulin resistance. Feeding a high-fat diet causes activation of the JNK1 signaling pathway, insulin resistance, and obesity in mice. Germ-line ablation of Jnk1 prevents both diet-induced obesity and insulin resistance. Genetic analysis indicates that the effects of JNK1 on insulin resistance can be separated from effects of JNK1 on obesity. Emerging research indicates that JNK1 plays multiple roles in the regulation of insulin resistance, including altered gene expression, hormone/cytokine production, and lipid metabolism. Together, these studies establish JNK1 as a potential pharmacological target for the development of drugs that might be useful for the treatment of insulin resistance, metabolic syndrome, and type 2 diabetes.
C1 [Sabio, Guadalupe] CSIC, Dept Immunol & Oncol, Ctr Nacl Biotecnol, Madrid, Spain.
   [Davis, Roger J.] Univ Massachusetts, Howard Hughes Med Inst, Sch Med, Worcester, MA 01605 USA.
   [Davis, Roger J.] Univ Massachusetts, Sch Med, Program Mol Med, Worcester, MA 01605 USA.
C3 Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Centro
   Nacional de Biotecnologia (CNB); University of Massachusetts System;
   University of Massachusetts Worcester; Howard Hughes Medical Institute;
   University of Massachusetts System; University of Massachusetts
   Worcester
RP Sabio, G (corresponding author), CSIC, Dept Immunol & Oncol, Ctr Nacl Biotecnol, Campus Cantoblanco, Madrid, Spain.
RI Sabio, Guadalupe/H-9733-2015
OI Sabio, Guadalupe/0000-0002-2822-0625; Davis, Roger/0000-0002-0130-1652
FU National Institutes of Health [DK080665, CA065861, NS054948];
   L'Oreal-Unesco
FX We thank Kathy Gemme and Catherine Mark for expert administrative
   assistance. The authors' studies were supported by grants from the
   National Institutes of Health (DK080665, CA065861, and NS054948) and a
   grant from L'Oreal-Unesco. G.S. is an Investigator of the Ramon y Cajal
   Program. RD. is a member of the NIDDK Diabetes and Endocrinology
   Research Center (P30 DK32520) at the University of Massachusetts Medical
   School and is an Investigator of the Howard Hughes Medical Institute.
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NR 70
TC 131
Z9 146
U1 2
U2 20
PU ELSEVIER SCIENCE LONDON
PI LONDON
PA 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND
SN 0968-0004
EI 1362-4326
J9 TRENDS BIOCHEM SCI
JI Trends Biochem.Sci.
PD SEP
PY 2010
VL 35
IS 9
BP 490
EP 496
DI 10.1016/j.tibs.2010.04.004
PG 7
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 651FZ
UT WOS:000281913500003
PM 20452774
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Cassis, LA
   Police, SB
   Yiannikouris, F
   Thatcher, SE
AF Cassis, Lisa A.
   Police, Sara B.
   Yiannikouris, Frederique
   Thatcher, Sean E.
TI Local adipose tissue renin-angiotensin system
SO CURRENT HYPERTENSION REPORTS
LA English
DT Article
ID ESSENTIAL-HYPERTENSION; CARDIOVASCULAR RISK; METABOLIC SYNDROME;
   PROMOTER ACTIVITY; EXPRESSION; OBESITY; GENE; DIFFERENTIATION;
   LOCALIZATION; POLYMORPHISM
AB A local renin-angiotensin system (RAS) has been proposed in adipocytes. Adipocytes are a suggested source of components of the RAS, with regulation of their production related to obesity-hypertension. Both angiotensin type 1 and 2 receptors have been localized to adipocytes. Angiotensin II has been demonstrated to regulate adipocyte growth and differentiation, lipid metabolism, and expression and release of adipokines and RAS components, and to promote oxidative stress. Differences in regional expression of RAS components in visceral versus subcutaneous adipose tissue have been suggested as a link between abdominal obesity and cardiovascular disease. Finally, several studies support anti hypertensive efficacy of RAS blockade in patients with type 2 diabetes and obesity. Future studies should address the role of adipocyte-specific deficiency of RAS components to definitively determine the relevance of the adipose RAS to normal physiology and to the development of hypertension.
C1 [Cassis, Lisa A.] Univ Kentucky, Grad Ctr Nutr Sci, Lexington, KY 40536 USA.
C3 University of Kentucky
RP Cassis, LA (corresponding author), Univ Kentucky, Grad Ctr Nutr Sci, Wethington Bldg,Room 521B,900 S Limestone St, Lexington, KY 40536 USA.
EM lcassis@uky.edu
RI Cassis, Lisa/G-1934-2011; Thatcher, Sean/G-1889-2011
OI Thatcher, Sean/0000-0002-1952-4459
FU NHLBI NIH HHS [R01 HL073085, R01 HL082791] Funding Source: Medline;
   NINDS NIH HHS [R01 NS039774] Funding Source: Medline
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NR 43
TC 177
Z9 197
U1 0
U2 7
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1522-6417
EI 1534-3111
J9 CURR HYPERTENS REP
JI Curr. Hypertens. Rep.
PD APR
PY 2008
VL 10
IS 2
BP 93
EP 98
DI 10.1007/s11906-008-0019-9
PG 6
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 307IO
UT WOS:000256312800003
PM 18474174
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Behnke, LM
AF Behnke, Lyn M.
TI The danger of underdiagnosing coronary microvascular disease in women
SO JOURNAL OF THE AMERICAN ASSOCIATION OF NURSE PRACTITIONERS
LA English
DT Article
DE False-negative stress test; Heart disease; Microvascular disease in
   women; Nonobstructive coronary artery disease
ID DIAGNOSIS; ISCHEMIA; DYSFUNCTION; WISE
AB Heart disease is the number one killer of women in the United States. Part of the difficulty with diagnosing heart disease in women is related to a disease process called coronary microvascular disease (CMVD; previously called syndrome X). Also known as nonobstructive coronary artery disease, CMVD is challenging to identify because often there is a lack of convincing evidence of an acute problem during evaluation. In these patients, the epicardial coronary arteries do not have visible blockages, and stress tests often are interpreted as normal or false positive. Therefore, symptomatic patients often are left undiagnosed, frustrated, and at risk of adverse cardiac events. Frequently, the only method of diagnosis is treatment of the symptoms. This information is provided to help advanced practice nurses and other clinicians diagnose and treat CMVD.
C1 [Behnke, Lyn M.] Univ Michigan, Sch Nursing, 303 E Kearsley St,2180 WSW, Flint, MI 48502 USA.
C3 University of Michigan System; University of Michigan Flint; University
   of Michigan
RP Behnke, LM (corresponding author), Univ Michigan, Sch Nursing, 303 E Kearsley St,2180 WSW, Flint, MI 48502 USA.
EM lbehnke@umich.edu
CR Abbott, 2021, MEDICARE PHYS FEE SC
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   American Heart Association, 2021, COR MICR DIS MVD
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NR 15
TC 1
Z9 1
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 2327-6886
EI 2327-6924
J9 J AM ASSOC NURSE PRA
JI J. Am. Assoc. Nurs. Pract.
PD MAY
PY 2022
VL 34
IS 5
BP 780
EP 783
DI 10.1097/JXX.0000000000000703
PG 4
WC Health Care Sciences & Services; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services; Nursing
GA 0W0BH
UT WOS:000788703000013
PM 35486868
DA 2025-06-11
ER

PT J
AU Vakana, E
   Altman, JK
   Platanias, LC
AF Vakana, Eliza
   Altman, Jessica K.
   Platanias, Leonidas C.
TI Targeting AMPK in the treatment of malignancies
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Article
DE AMPK; mTOR; CANCER
ID ACTIVATED PROTEIN-KINASE; BREAST-CANCER CELLS; OVARIAN-CANCER;
   LUNG-CANCER; METABOLIC SYNDROME; DIABETIC-PATIENTS; UP-REGULATION;
   METFORMIN; GROWTH; MTOR
AB The AMPK pathway is a metabolic stress-related and energy censor pathway which plays important regulatory roles in normal and malignant cells. This cellular cascade controls generation of signals for initiation of mRNA translation via the mTOR pathway and exhibits regulatory roles on the initiation of autophagy. AMPK activators have been shown to suppress mTOR activity and to negatively control malignant transformation and cell proliferation of diverse malignant cell types. Such properties of AMPK inducers have generated substantial interest for the use of AMPK targeting compounds as antineoplastic agents and have provoked extensive research efforts to better define and classify the mechanisms controlling AMPK activity and its functional consequences in malignant cells. J. Cell. Biochem. 113: 404409, 2012. (C) 2011 Wiley Periodicals, Inc.
C1 [Platanias, Leonidas C.] Northwestern Univ, Sch Med, Robert H Lurie Comprehens Canc Ctr, Chicago, IL 60611 USA.
   Northwestern Univ, Sch Med, Div Hematol Oncol, Chicago, IL 60611 USA.
   Jesse Brown VA Med Ctr, Chicago, IL 60611 USA.
C3 Ann & Robert H. Lurie Children's Hospital of Chicago; Northwestern
   University; Robert H. Lurie Comprehensive Cancer Center; Northwestern
   University; US Department of Veterans Affairs; Veterans Health
   Administration (VHA); Jesse Brown VA Medical Center
RP Platanias, LC (corresponding author), Northwestern Univ, Sch Med, Robert H Lurie Comprehens Canc Ctr, 303 E Super St,Lurie 3-107, Chicago, IL 60611 USA.
EM l-platanias@northwestern.edu
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NR 73
TC 35
Z9 40
U1 0
U2 21
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0730-2312
EI 1097-4644
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PD FEB
PY 2012
VL 113
IS 2
BP 404
EP 409
DI 10.1002/jcb.23369
PG 6
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA 872XB
UT WOS:000298843200005
PM 21928327
DA 2025-06-11
ER

PT J
AU Podhorecka, M
   Ibanez, B
   Dmoszynska, A
AF Podhorecka, Monika
   Ibanez, Blanca
   Dmoszynska, Anna
TI Metformin - its potential anti-cancer and anti-aging effects
SO POSTEPY HIGIENY I MEDYCYNY DOSWIADCZALNEJ
LA English
DT Review
DE metformin; cancer; aging; AMPK; mTOR
ID ACTIVATED PROTEIN-KINASE; DNA-DAMAGE; LIFE-SPAN; HEPATIC
   GLUCONEOGENESIS; METABOLIC CHECKPOINT; CANCER PREVENTION; DIRECT
   INHIBITION; C. ELEGANS; DRUG; AUTOPHAGY
AB The generally accepted mechanism of metformin's effect is stimulation of adenosine monophosphate (AMP)-activated protein kinase (AMPK). AMPK is directly activated by an increase in AMP: ATP ratio in metabolic stress conditions including hypoxia and glucose deprivation. Lately, many novel pathways, besides AMPK induction, have been revealed, which can explain some of metformin's beneficial effects. It may help to identify new targets for treatment of diabetes and metabolic syndrome. Moreover, metformin is now attracting the attention of researchers in fields other than diabetes, as it has been shown to have anti-cancer, immunoregulatory and anti-aging effects. The aim of this review is to describe the potential anti-cancer and anti-aging properties of metformin and discuss the possible underlying mechanisms.
C1 [Podhorecka, Monika; Ibanez, Blanca] Med Univ Lublin, Dept Hematooncol & Bone Marrow Transplantat, Ul Stasz 11, PL-20081 Lublin, Poland.
   [Dmoszynska, Anna] Med Univ Lublin, Polish Multiple Myeloma Grp, Lublin, Poland.
C3 Medical University of Lublin; Medical University of Lublin
RP Podhorecka, M (corresponding author), Med Univ Lublin, Dept Hematooncol & Bone Marrow Transplantat, Ul Stasz 11, PL-20081 Lublin, Poland.
EM monika.podhorecka@onet.pl
RI Ibanez-Rosello, Blanca/S-5324-2017
OI Podhorecka, Monika/0000-0001-9458-0891
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NR 57
TC 150
Z9 160
U1 1
U2 35
PU POLISH ACAD SCIENCES, INST IMMUNOL & EXP THERAPY
PI WROCLAW
PA RUDOLF WEIGL 12, WROCLAW, 53-114, POLAND
SN 0032-5449
EI 1732-2693
J9 POSTEP HIG MED DOSW
JI Postep. Hig. Med. Dosw.
PD MAR 2
PY 2017
VL 71
BP 170
EP 175
PG 6
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA EN7IL
UT WOS:000396175200004
PM 28258677
DA 2025-06-11
ER

PT J
AU Xu, JY
   Li, ZP
   Zhang, L
   Ji, G
AF Xu, Jiao-Ya
   Li, Zhong-Ping
   Zhang, Li
   Ji, Guang
TI Recent insights into farnesoid X receptor in non-alcoholic fatty liver
   disease
SO WORLD JOURNAL OF GASTROENTEROLOGY
LA English
DT Review
DE Farnesoid X receptor; Non-alcoholic fatty liver disease; Mechanism;
   Therapy; Lipid metabolism
ID BILE-ACID RECEPTORS; HEPATIC STEATOSIS; ACTIVATED RECEPTOR; REGULATORY
   CASCADE; OXIDATIVE STRESS; MURINE MODEL; FXR; CHOLESTEROL; EXPRESSION;
   METABOLISM
AB Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic syndrome and is one of the most prevalent liver disorders worldwide. NAFLD can gradually progress to liver inflammation, fibrosis, cirrhosis and even hepatocellular carcinoma. However, the pathogenesis of NAFLD is complex, and no efficient pharmaceutic treatments have yet been established for NAFLD. Accumulating data have shown that the farnesoid X receptor (FXR) plays important roles not only in bile acid metabolism, but also in lipid and carbohydrate homeostasis, inflammatory responses, among others. In this review, we aim to highlight the role of FXR in the pathogenesis and treatment of NAFLD. (C) 2014 Baishideng Publishing Group Inc. All rights reserved.
C1 [Xu, Jiao-Ya; Li, Zhong-Ping; Zhang, Li; Ji, Guang] Shanghai Univ Tradit Chinese Med, Longhua Hosp, Inst Digest Dis, Shanghai 200032, Peoples R China.
   [Ji, Guang] Shanghai Univ Tradit Chinese Med, Shanghai Municipal Educ Commiss, E Inst, Shanghai 201203, Peoples R China.
C3 Shanghai University of Traditional Chinese Medicine; Shanghai University
   of Traditional Chinese Medicine; Shanghai Municipal Education Commission
   (SHMEC)
RP Ji, G (corresponding author), Shanghai Univ Tradit Chinese Med, Longhua Hosp, Inst Digest Dis, 725 South Wanping Rd, Shanghai 200032, Peoples R China.
EM jiliver@vip.sina.com
FU National Nature Science Foundation of China [81273727, 81302927];
   Innovation Program of Shanghai Municipal Education Commission [14YZ054]
FX Supported by National Nature Science Foundation of China, No. 81273727
   and No. 81302927; and Innovation Program of Shanghai Municipal Education
   Commission, No. 14YZ054
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NR 86
TC 29
Z9 37
U1 1
U2 24
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 8226 REGENCY DR, PLEASANTON, CA 94588 USA
SN 1007-9327
EI 2219-2840
J9 WORLD J GASTROENTERO
JI World J. Gastroenterol.
PD OCT 7
PY 2014
VL 20
IS 37
BP 13493
EP 13500
DI 10.3748/wjg.v20.i37.13493
PG 8
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA AR9GN
UT WOS:000343881200023
PM 25309079
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Owen, MK
   Noblet, JN
   Sassoon, DJ
   Conteh, AM
   Goodwill, AG
   Tune, JD
AF Owen, Meredith Kohr
   Noblet, Jillian N.
   Sassoon, Daniel J.
   Conteh, Abass M.
   Goodwill, Adam G.
   Tune, Johnathan D.
TI Perivascular Adipose Tissue and Coronary Vascular Disease
SO ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
LA English
DT Article
DE adipokines; adipose tissue; obesity
ID INTERNAL THORACIC ARTERY; NITRIC-OXIDE SYNTHASE; VOLTAGE-DEPENDENT K+;
   C-REACTIVE PROTEIN; ENDOTHELIAL DYSFUNCTION; EPICARDIAL FAT;
   SMOOTH-MUSCLE; METABOLIC SYNDROME; OXIDATIVE STRESS; VASA-VASORUM
AB Coronary perivascular adipose tissue is a naturally occurring adipose tissue depot that normally surrounds the major coronary arteries on the surface of the heart. Although originally thought to promote vascular health and integrity, there is a growing body of evidence to support that coronary perivascular adipose tissue displays a distinct phenotype relative to other adipose depots and is capable of producing local factors with the potential to augment coronary vascular tone, inflammation, and the initiation and progression of coronary artery disease. The purpose of the present review is to outline previous findings about the cardiovascular effects of coronary perivascular adipose tissue and the potential mechanisms by which adipose-derived factors may influence coronary vascular function and the progression of atherogenesis.
C1 [Owen, Meredith Kohr] Univ N Carolina, Sch Med, Dept Cell Biol & Physiol, Chapel Hill, NC USA.
   [Noblet, Jillian N.; Sassoon, Daniel J.; Conteh, Abass M.; Goodwill, Adam G.; Tune, Johnathan D.] Indiana Univ Sch Med, Dept Cellular & Integrat Physiol, Indianapolis, IN 46202 USA.
C3 University of North Carolina; University of North Carolina Chapel Hill;
   University of North Carolina School of Medicine; Indiana University
   System; Indiana University Bloomington
RP Tune, JD (corresponding author), Indiana Univ Sch Med, Dept Cellular & Integrat Physiol, 635 Barnhill Dr, Indianapolis, IN 46202 USA.
EM jtune@iu.edu
RI Goodwill, Adam/N-4889-2016; Sassoon, Daniel/F-3892-2015; Stefanadis,
   Christodoulos/ABH-2232-2020
OI Goodwill, Adam/0000-0003-3701-3713; Tune, Johnathan/0000-0003-2959-0801;
   Sassoon, Daniel/0000-0002-6785-4663; Stefanadis,
   Christodoulos/0000-0001-5974-6454
FU National Institutes of Health [HL092245, HL117620]; Indiana University
   Health-Indiana University School of Medicine Strategic Research
   Initiative; American Heart Association [13POST1681001813, HL117620-S1,
   TL1 TR000162]
FX This publication was made possible by funding from National Institutes
   of Health HL092245, HL117620, and by the Indiana University
   Health-Indiana University School of Medicine Strategic Research
   Initiative (J.D. Tune). Additional support was also provided by the
   American Heart Association 13POST1681001813 (A.G. Goodwill), HL117620-S1
   (A.M. Conteh), and TL1 TR000162 (D.J. Sassoon).
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NR 104
TC 41
Z9 47
U1 0
U2 7
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1079-5642
EI 1524-4636
J9 ARTERIOSCL THROM VAS
JI Arterioscler. Thromb. Vasc. Biol.
PD AUG
PY 2014
VL 34
IS 8
BP 1643
EP 1649
DI 10.1161/ATVBAHA.114.303033
PG 7
WC Hematology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Hematology; Cardiovascular System & Cardiology
GA AL6WM
UT WOS:000339274200009
PM 24790142
OA Green Submitted, Green Accepted
DA 2025-06-11
ER

PT J
AU Soldatos, G
   Cooper, ME
   Jandeleit-Dahm, KAM
AF Soldatos, G
   Cooper, ME
   Jandeleit-Dahm, KAM
TI Advanced-glycation end products in insulin-resistant states
SO CURRENT HYPERTENSION REPORTS
LA English
DT Article
ID ISLET AMYLOID POLYPEPTIDE; NECROSIS-FACTOR-ALPHA; ENDOTHELIAL-CELL
   DYSFUNCTION; NITRIC-OXIDE SYNTHASE; ADIPOSE-TISSUE; RISK-FACTORS;
   ADVANCED GLYCOSYLATION; OXIDATIVE STRESS; TNF-ALPHA; DIABETIC
   COMPLICATIONS
AB Insulin resistance is a central component of a number of clinical conditions, including the metabolic syndrome, diabetes, and hypertension. There is emerging evidence that the consequent hyperinsulinemia. and visceral adiposity may be directly responsible for the excess cardiovascular morbidity and mortality seen in these conditions. Advancedglycation end products, a chemically diverse group of compounds found in higher levels in insulin-resistant states, have also been shown to adversely affect endothelial function as well as activate numerous intracellular signaling pathways implicated in the atherosclerotic pathway. In this review, we summarize the factors thought to be important in both the initiation and exacerbation of the insulin-resistant state, and directly examine the potential role of advanced-glycation end products in this process.
C1 Baker Heart Res Inst, Melbourne, Vic 3181, Australia.
C3 Baker Heart and Diabetes Institute
RP Soldatos, G (corresponding author), Baker Heart Res Inst, Commercial Rd, Melbourne, Vic 3181, Australia.
EM Karin.jandeleit-Dahm@baker.edu.au
RI Cooper, Mark/AAC-5326-2020
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NR 59
TC 26
Z9 29
U1 0
U2 7
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1522-6417
J9 CURR HYPERTENS REP
JI Curr. Hypertens. Rep.
PD APR
PY 2005
VL 7
IS 2
BP 96
EP 102
DI 10.1007/s11906-005-0081-5
PG 7
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 991HF
UT WOS:000233802300004
PM 15748532
DA 2025-06-11
ER

PT J
AU Saberi-Karimian, M
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   Sahebkar, A
AF Saberi-Karimian, Maryann
   Katsiki, Niki
   Caraglia, Michele
   Boccellino, Mariarosaria
   Majeed, Muhammed
   Sahebkar, Amirhossein
TI Vascular endothelial growth factor: An important molecular target of
   curcumin
SO CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
LA English
DT Review
DE Curcumin; vascular endothelial growth factor; breast cancer; age-related
   macular degeneration; angiogenesis
ID BREAST-CANCER CELLS; NF-KAPPA-B; RANDOMIZED CONTROLLED-TRIAL; FATTY
   LIVER-DISEASE; QUALITY-OF-LIFE; METABOLIC SYNDROME; OXIDATIVE STRESS;
   DOUBLE-BLIND; CLINICAL-PRACTICE; OVARIAN-CANCER
AB The discovery of Vascular Endothelial Growth Factor (VEGF), the key modulator of angiogenesis, has triggered intensive research on anti-angiogenic therapeutic modalities. Although several clinical studies have validated anti-VEGF therapeutics, with few of them approved by the U.S. Food and Drug Administration (FDA), anti-angiogenic therapy is still in its infancy. Phytochemicals are compounds that have several metabolic and health benefits. Curcumin, the yellow pigment derived from turmeric (Curcuma longa L.) rhizomes, has a wide range of pharmaceutical properties. It has also been shown to inhibit VEGF by several studies. In this review, we elaborate the effect of curcumin on VEGF and angiogenesis and its therapeutic application.
C1 [Saberi-Karimian, Maryann] Mashhad Univ Med Sci, Sch Med, Dept Modern Sci & Technol, Student Res Comm, Mashhad, Razavi Khorasan, Iran.
   [Katsiki, Niki] Aristotle Univ Thessaloniki, Hippocration Hosp, Med Sch, Propedeut Dept Internal Med 2, Thessaloniki, Greece.
   [Caraglia, Michele; Boccellino, Mariarosaria] Univ Campania L Vanvitelli 7, Dept Biochem Biophys & Gen Pathol, Via L De Crecchio 7, Naples, Italy.
   [Majeed, Muhammed] Sabinsa Corp, East Windsor, NJ USA.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Biotechnol Res Ctr, Mashhad, Razavi Khorasan, Iran.
C3 Mashhad University of Medical Sciences; Aristotle University of
   Thessaloniki; Mashhad University of Medical Sciences
RP Sahebkar, A (corresponding author), Mashhad Univ Med Sci, Sch Med, Dept Med Biotechnol, POB 91779-48564, Mashhad, Razavi Khorasan, Iran.
EM sahebkara@mums.ac.ir
RI Caraglia, Michele/AFY-9729-2022; Sahebkar, Amirhossein/B-5124-2018;
   KATSIKI, NIKI/ADE-7999-2022
OI KATSIKI, NIKI/0000-0003-0894-2644
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NR 185
TC 54
Z9 59
U1 1
U2 74
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1040-8398
EI 1549-7852
J9 CRIT REV FOOD SCI
JI Crit. Rev. Food Sci. Nutr.
PD JAN 19
PY 2019
VL 59
IS 2
BP 299
EP 312
DI 10.1080/10408398.2017.1366892
PG 14
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA HR1HL
UT WOS:000462881700007
PM 28853916
DA 2025-06-11
ER

PT J
AU Warmbrunn, MV
   Bahrar, H
   de Clercq, NC
   Koopen, AM
   de Groot, PF
   Rutten, J
   Joosten, LAB
   Kootte, RS
   Bouter, KEC
   ter Horst, KW
   Hartstra, AV
   Serlie, MJ
   Soeters, MR
   van Raalte, DH
   Davids, M
   Levin, E
   Herrema, H
   Riksen, NP
   Netea, MG
   Groen, AK
   Nieuwdorp, M
AF Warmbrunn, Moritz V.
   Bahrar, Harsh
   de Clercq, Nicolien C.
   Koopen, Annefleur M.
   de Groot, Pieter F.
   Rutten, Joost
   Joosten, Leo A. B.
   Kootte, Ruud S.
   Bouter, Kristien E. C.
   ter Horst, Kasper W.
   Hartstra, Annick V.
   Serlie, Mireille J.
   Soeters, Maarten R.
   van Raalte, Daniel H.
   Davids, Mark
   Levin, Evgeni
   Herrema, Hilde
   Riksen, Niels P.
   Netea, Mihai G.
   Groen, Albert K.
   Nieuwdorp, Max
TI Novel Proteome Targets Marking Insulin Resistance in Metabolic Syndrome
SO NUTRIENTS
LA English
DT Article
DE insulin resistance; obesity; proteomics; tumor necrosis factor;
   Interleukin-1
ID EPICARDIAL ADIPOSE-TISSUE; OXIDATIVE STRESS; RISK; FAT; TRAIL;
   ASSOCIATIONS; INFLAMMATION; SENSITIVITY; MICROBIOTA; ACCURATE
AB Context/Objective: In order to better understand which metabolic differences are related to insulin resistance in metabolic syndrome (MetSyn), we used hyperinsulinemic-euglycemic (HE) clamps in individuals with MetSyn and related peripheral insulin resistance to circulating biomarkers. Design/Methods: In this cross-sectional study, HE-clamps were performed in treatment-naive men (n = 97) with MetSyn. Subjects were defined as insulin-resistant based on the rate of disappearance (Rd). Machine learning models and conventional statistics were used to identify biomarkers of insulin resistance. Findings were replicated in a cohort with n = 282 obese men and women with (n = 156) and without (n = 126) MetSyn. In addition to this, the relation between biomarkers and adipose tissue was assessed by nuclear magnetic resonance imaging. Results: Peripheral insulin resistance is marked by changes in proteins related to inflammatory processes such as IL-1 and TNF-receptor and superfamily members. These proteins can distinguish between insulin-resistant and insulin-sensitive individuals (AUC = 0.72 +/- 0.10) with MetSyn. These proteins were also associated with IFG, liver fat (rho 0.36, p = 1.79 x 10-9) and visceral adipose tissue (rho = 0.35, p = 6.80 x 10-9). Interestingly, these proteins had the strongest association in the MetSyn subgroup compared to individuals without MetSyn. Conclusions: MetSyn associated with insulin resistance is characterized by protein changes related to body fat content, insulin signaling and pro-inflammatory processes. These findings provide novel targets for intervention studies and should be the focus of future in vitro and in vivo studies.
C1 [Warmbrunn, Moritz V.; de Clercq, Nicolien C.; Koopen, Annefleur M.; de Groot, Pieter F.; Kootte, Ruud S.; Bouter, Kristien E. C.; ter Horst, Kasper W.; Hartstra, Annick V.; Davids, Mark; Levin, Evgeni; Herrema, Hilde; Groen, Albert K.; Nieuwdorp, Max] Amsterdam Univ Med Ctr, Dept Internal & Vasc Med, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands.
   [Warmbrunn, Moritz V.] Univ Amsterdam, Amsterdam UMC, Gastroenterol & Hepatol, Amsterdam Gastroenterol Endocrinol Metab, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands.
   [Warmbrunn, Moritz V.] Univ Amsterdam, Amsterdam UMC, Cardiovasc Sci, Amsterdam Cardiovasc Sci, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands.
   [Bahrar, Harsh; Rutten, Joost; Joosten, Leo A. B.; Riksen, Niels P.; Netea, Mihai G.] Radboud Univ Nijmegen Med Ctr, Dept Internal Med, NL-6525 EP Nijmegen, Netherlands.
   [Serlie, Mireille J.; Soeters, Maarten R.] Univ Amsterdam, Dept Endocrinol & Metab, Amsterdam UMC, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands.
   [van Raalte, Daniel H.] Vrije Univ Amsterdam Med Ctr, Diabet Ctr, Dept Endocrniol & Metab, Amsterdam UMC, Boelelaan 1117, NL-1081 HV Amsterdam, Netherlands.
   [van Raalte, Daniel H.] Vrije Univ Amsterdam, Amsterdam Cardiovasc Sci, Boelelaan 1117, NL-1081 HV Amsterdam, Netherlands.
C3 University of Amsterdam; University of Amsterdam; Radboud University
   Nijmegen; University of Amsterdam; Vrije Universiteit Amsterdam; VU
   UNIVERSITY MEDICAL CENTER; Vrije Universiteit Amsterdam
RP Nieuwdorp, M (corresponding author), Amsterdam Univ Med Ctr, Dept Internal & Vasc Med, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands.
EM m.v.warmbrunn@amsterdamumc.nl; harsh.bahrar@radboudumc.nl;
   n.c.declercq@amsterdamumc.nl; p.f.degroot@amsterdamumc.nl;
   r.s.kootte@umcutrecht.nl; a.k.groen@amsterdamumc.nl;
   m.nieuwdorp@amsterdamumc.nl
RI Riksen, Niels/G-8260-2015; Netea, Mihai/N-5155-2014
OI riksen, niels/0000-0001-9197-8124; Davids, Mark/0000-0003-3081-9124;
   Joosten, Leo/0000-0001-6166-9830
FU Netherlands CardioVascular Research Committee (CVON) IN-CONTROL-II grant
   from the Dutch Heart Foundation; Dutch Cardiovascular Alliance; ZonMw
   Vici grant [09150182010020]; Leducq consortium grant [17CVD01]; Dutch
   Diabetes Research Foundation [2019.82.004]; Deutsche
   Forschungsgemeinschaft (DFG, German Research Foundation) [SFB 1454,
   432325352]
FX L.A.B. Joosten: N.P. Riksen, M.G. Netea, A.K Groen, and M. Nieuwdorp are
   supported by a Netherlands CardioVascular Research Committee (CVON)
   IN-CONTROL-II grant (2018-27) from the Dutch Heart Foundation and Dutch
   Cardiovascular Alliance. Max Nieuwdorp is supported by a ZonMw Vici
   grant 2020 (09150182010020) and a Leducq consortium grant 17CVD01. Hilde
   Herrema is supported by a Senior Fellowship of the Dutch Diabetes
   Research Foundation (2019.82.004). Funded by the Deutsche
   Forschungsgemeinschaft (DFG, German Research Foundation)-SFB
   1454-project number 432325352.
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NR 53
TC 1
Z9 1
U1 0
U2 0
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JUN
PY 2024
VL 16
IS 12
AR 1822
DI 10.3390/nu16121822
PG 15
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA WP3L5
UT WOS:001256037900001
PM 38931177
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU L'hadj, I
   Azzi, R
   Lahfa, F
   Koceir, EA
   Omari, N
AF L'hadj, Imene
   Azzi, Rachid
   Lahfa, Farid
   Koceir, Elhadj Ahmed
   Omari, Naima
TI The nutraceutical potential of Lepidium sativum L. seed
   flavonoid-rich extract in managing metabolic syndrome components
SO JOURNAL OF FOOD BIOCHEMISTRY
LA English
DT Article
DE flavonoids; high-fat diet; Lepidium sativum L.; liquid chromatography;
   metabolic syndrome; pancreatic islets
ID HIGH-FAT-DIET; INSULIN-RESISTANCE; OXIDATIVE STRESS; AQUEOUS EXTRACT;
   PHENOLIC-ACIDS; GLUCOSE; QUERCETIN; CELLS; RAT; INHIBITION
AB The present study aimed to investigate the phytochemical and pharmacological identities of a Lepidium sativum L. (LS) flavonoid-rich extract and its beneficial effects on metabolic, hormonal, and histological status. Chemical screening, as well as high-performance liquid chromatography with diode-array detection (HPLC-DAD) identified high concentrations of the main flavonoid compounds in LS crude extract such as flavonols (quercetin, kaempferol), flavones (luteolin, apigenin), and especially flavanones (naringin, naringenin). Examinations of the biochemical and histopathological aspects showed the curative effects carried by LS flavonoid-rich extracts on high-fat diet-fed Wistar rats. In this study, we propose that these molecules probably exerted the bioactivity observed in the treated group through improving insulin sensitivity, dyslipidemia, inflammation, and pancreas beta cell integrity.
   Practical applications
   The LS seed is widely used in traditional medicine to treat hyperglycemia and inflammation. During the traditional mixture preparation, the thermal procedures could impair the bioactions of the most interesting group of LS phytoconstituants, flavonoids. In the present study, we propose an appropriate procedure to preserve those phytochemicals and suggest them as a substitute for the management of metabolic diseases. The dried LS extract showed an incredible set of effective flavonoids, which revealed hypoglycemic, hypolipidemic, anti-inflammatory, cytoprotective, and antidiabetic activities. Thus, LS flavonoids constitute a remarkable product to consider in pharmaceutical industry targeting diabetes and heart diseases. Due to their enormous antioxidant potential, the LS flavonoids could be also used in food engineering and cosmetic preparations. Their practical applications is however often limited by low solubility and stability in lipophilic media. Therefore, a modification of the flavonoid structure is possibly required.
C1 [L'hadj, Imene; Koceir, Elhadj Ahmed; Omari, Naima] Univ Sci & Technol Houari Boumediene, Dept Biol & Physiol Organisms, Bab Ezzouar, Algeria.
   [Azzi, Rachid; Lahfa, Farid] Univ AbouBekrBelkaid, Dept Synth & Biol Act, Tilimsen, Algeria.
C3 University Science & Technology Houari Boumediene
RP L'hadj, I (corresponding author), USTHB, Lab Bioenerget & Intermediary Metab, Dept Biol & Physiol Organisms, FSB, BP32, Algiers 16111, Algeria.
EM Lhadj.Lhadj@rocketmail.com
FU Algerian Agency for the Research & Development in Health from the
   National Administration of Algerian Higher Education and Scientific
   Research [208/ANDRS/2011, 41/ANDRS/2011]
FX This work was supported by the Algerian Agency for the Research &
   Development in Health from the National Administration of Algerian
   Higher Education and Scientific Research (PNR nos. 208/ANDRS/2011 and
   41/ANDRS/2011)
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NR 82
TC 10
Z9 11
U1 0
U2 18
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0145-8884
EI 1745-4514
J9 J FOOD BIOCHEM
JI J. Food Biochem.
PD MAR
PY 2019
VL 43
IS 3
AR e12725
DI 10.1111/jfbc.12725
PG 11
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA HO6UW
UT WOS:000461068900030
PM 31353542
OA gold
DA 2025-06-11
ER

PT J
AU Ríos, JL
   Giner, RM
   Marín, M
   Recio, MC
AF Rios, Jose-Luis
   Giner, Rosa M.
   Marin, Marta
   Carmen Recio, M.
TI A Pharmacological Update of Ellagic Acid
SO PLANTA MEDICA
LA English
DT Article
DE ellagic acid; metabolic syndrome; neuroprotection; hepatoprotection;
   cardiovascular effects; cancer
ID PUNICA-GRANATUM L.; NF-KAPPA-B; INDUCED OXIDATIVE STRESS; IN-VITRO
   ANTIOXIDANT; ADVANCED GLYCATION ENDPRODUCTS; MUSCLE-CELL PROLIFERATION;
   POMEGRANATE RIND EXTRACT; VITAMIN-E SUCCINATE; ANTIINFLAMMATORY
   ACTIVITY; ANTIPROLIFERATIVE ACTIVITIES
AB Ellagic acid is a common metabolite present in many medicinal plants and vegetables. It is present either in free form or as part of more complex molecules (ellagitannins), which can be metabolized to liberate ellagic acid and several of its metabolites, including urolithins. While ellagic acids antioxidant properties are doubtless responsible for many of its pharmacological activities, other mechanisms have also been implicated in its various effects, including its ability to reduce the lipidemic profile and lipid metabolism, alter pro-inflammatory mediators (tumor necrosis factor- , interleukin-1 , interleukin-6), and decrease the activity of nuclear factor- B while increasing nuclear factor erythroid 2-related factor 2 expression. These events play an important role in ellagic acids anti-atherogenic, anti-inflammatory, and neuroprotective effects. Several of these activities, together with the effect of ellagic acid on insulin, glycogen, phosphatases, aldose reductase, sorbitol accumulation, advanced glycation end-product formation, and resistin secretion, may explain its effects on metabolic syndrome and diabetes. In addition, results from recent research have increased the interest in ellagic acid, both as a potential protective agent of the liver and skin and as a potential anticancer agent, due to the specific mechanisms affecting cell proliferation, apoptosis, DNA damage, and angiogenesis and its aforementioned anti-inflammatory properties. Taken together, these effects make ellagic acid a highly interesting compound that may contribute to different aspects of health; however, more studies are needed, especially on the compounds pharmacokinetic profile. In this review, we selected papers published from 2005 to the present.
C1 [Rios, Jose-Luis; Giner, Rosa M.; Carmen Recio, M.] Univ Valencia, Fac Farm, Dept Farmacol, Ave Vicent Andres Estelles S-N, E-46100 Burjassot, Spain.
   [Marin, Marta] CEU Univ, Univ Cardenal Herrera CEU, Fac Ciencias Salud, Dept Farm, Valencia, Spain.
C3 University of Valencia; Universidad CEU Cardenal Herrera
RP Ríos, JL (corresponding author), Univ Valencia, Fac Farm, Dept Farmacol, Ave Vicent Andres Estelles S-N, E-46100 Burjassot, Spain.
EM riosjl@uv.es
RI Giner, Rosa/AAP-1773-2020; Denia, José Luis/G-3190-2016
OI Giner, RM/0000-0001-5455-5923; MCarmen, Recio/0000-0002-0933-2306
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NR 244
TC 286
Z9 294
U1 19
U2 178
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0032-0943
EI 1439-0221
J9 PLANTA MED
JI Planta Med.
PD OCT
PY 2018
VL 84
IS 15
BP 1068
EP 1093
DI 10.1055/a-0633-9492
PG 26
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA GW1BC
UT WOS:000446603200001
PM 29847844
OA Green Submitted, Bronze
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Bruno, RM
   Reesink, KD
   Ghiadoni, L
AF Bruno, R. M.
   Reesink, K. D.
   Ghiadoni, L.
TI Advances in the non-invasive assessment of vascular dysfunction in
   metabolic syndrome and diabetes: Focus on endothelium, carotid mechanics
   and renal vessels
SO NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
LA English
DT Review
DE Endothelium; Flow mediated; dilation; Carotid artery; Biomechanics;
   Arterial stiffness; Wall stress; Nephropathy; Renal blood flow
ID GLOMERULAR-FILTRATION-RATE; FLOW-MEDIATED DILATION; SMOOTH-MUSCLE
   FUNCTION; ARTERIAL STIFFNESS; RESISTIVE INDEX; HYPERTENSIVE PATIENTS;
   MICROVASCULAR DYSFUNCTION; INSULIN-RESISTANCE; REFERENCE VALUES;
   BLOOD-PRESSURE
AB Aim: The present paper is a selective review on the methodology and clinical significance of techniques to assess specifically endothelial function, carotid mechanics and renal vascular function, particularly in the light of vascular dysfunction in metabolic syndrome and type 2 diabetes.
   Data synthesis: Endothelial dysfunction appears to be earlier detectable in the microcirculation of patients with altered glucose metabolism, while it attains significance in the macrocirculation at more advanced disease stages. Smooth muscle cell dysfunction is now increasingly recognized to play a role both in the development of endothelial dysfunction and abnormal arterial distensibility. Furthermore, impaired glucose metabolism affects carotid mechanics through medial calcification, structural changes in extracellular matrix due to advanced glycation and modification of the collagen/elastin material stiffness. The assessment of renal vascular function by dynamic ultrasound or magnetic resonance imaging has recently emerged as an appealing target for identifying subtle vascular alterations responsible for the development of diabetic nephropathy.
   Conclusions: Vascular dysfunction represents a major mechanism for the development of cardiovascular disease in patients with abnormal glucose metabolism. Hence, the currently available non-invasive techniques to assess early structural and vascular abnormalities merit recommendation in this population, although their predictive value and sensitivity to monitor treatmentinduced changes have not yet been established and are still under investigation. (C) 2016 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B. V. All rights reserved.
C1 [Bruno, R. M.; Ghiadoni, L.] Univ Pisa, Dept Clin & Expt Med, Pisa, Italy.
   [Reesink, K. D.] Maastricht Univ, CARIM Sch Cardiovascular Dis, Dept Biomed Engn, Maastricht, Netherlands.
   [Reesink, K. D.] Maastricht Univ Med Ctr, Dept Biomed Engn, Cardiovascular Ctr, Maastricht, Netherlands.
   [Ghiadoni, L.] Univ Pisa, Dept Clin & Expt Med, Via Roma 67, I-56126 Pisa, Italy.
C3 University of Pisa; Maastricht University; Maastricht University;
   Maastricht University Medical Centre (MUMC); University of Pisa
RP Ghiadoni, L (corresponding author), Univ Pisa, Dept Clin & Expt Med, Pisa, Italy.; Ghiadoni, L (corresponding author), Univ Pisa, Dept Clin & Expt Med, Via Roma 67, I-56126 Pisa, Italy.
EM lorenzo.ghiadoni@med.unipi.it
RI Ghiadoni, Lorenzo/AAC-5176-2022; Bruno, Rosa Maria/C-3594-2015
OI Reesink, Koen/0000-0003-2354-883X; Bruno, Rosa
   Maria/0000-0002-6107-3356; Ghiadoni, Lorenzo/0000-0002-7399-2720
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NR 85
TC 13
Z9 13
U1 0
U2 12
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0939-4753
EI 1590-3729
J9 NUTR METAB CARDIOVAS
JI Nutr. Metab. Carbiovasc. Dis.
PD FEB
PY 2017
VL 27
IS 2
BP 121
EP 128
DI 10.1016/j.numecd.2016.09.004
PG 8
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism; Nutrition
   & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism;
   Nutrition & Dietetics
GA EP1EF
UT WOS:000397127500003
PM 27773467
DA 2025-06-11
ER

PT J
AU Del Ben, M
   Polimeni, L
   Baratta, F
   Pastori, D
   Angelico, F
AF Del Ben, Maria
   Polimeni, Licia
   Baratta, Francesco
   Pastori, Daniele
   Angelico, Francesco
TI The role of nutraceuticals for the treatment of non-alcoholic fatty
   liver disease
SO BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
LA English
DT Review
DE antioxidants; non-alcoholic fatty liver disease; nutraceuticals; omega-3
   fatty acids; polyphenols
ID E SERUM-LEVELS; VITAMIN-E; OXIDATIVE STRESS; INSULIN-RESISTANCE;
   METABOLIC SYNDROME; RESVERATROL SUPPLEMENTATION; DIETARY ANTIOXIDANTS;
   HEPATIC STEATOSIS; CONTROLLED-TRIAL; DOUBLE-BLIND
AB Non-alcoholic fatty liver disease (NAFLD) represents the most common chronic liver disease. It is characterized by a wide spectrum of hepatic changes, which may progress to liver fibrosis and to cirrhosis. NAFLD is considered as the hepatic component of the metabolic syndrome but mechanisms underlying the onset and progression of NAFLD are still under investigation. The traditional 'two hit hypothesis' has been developed within a more complex ` multiple parallel hit hypothesis' which comprises a wide spectrum of parallel hits. Many therapeutic approaches have been proposed so far and several types of nutraceuticals have been suggested for the treatment of NAFLD and non-alcoholic steatohepatitis (NASH), the most promising of which are those with antioxidant effects. In particular, vitamin E appears to be effective for the treatment of nondiabetic subjects with more advanced NASH, although the high suggested daily dosages are a matter of concern. Moreover, polyphenols reduce liver fat accumulation, mainly by inhibiting lipogenesis. At present, there are insufficient data to support the use of vitamin C supplements in patients with NAFLD. Data on polyunsaturated fatty acid (PUFA) supplementation are heterogeneous, and no well-designed randomized controlled studies (RCTs) of adequate size, with histological assessment of steatosis, have been conducted. Based on the available data, silymarin supplementation for the treatment of NAFLD seems to have a favourable effect. The results with anti-inflammatory agents, such as vitamin D and carnitine are uncertain. In conclusion, there are insufficient data either to support or refute the use of nutraceuticals for subjects with NAFLD. Further RTCs, with histological changes as an outcome measure, are needed.
C1 [Del Ben, Maria; Polimeni, Licia; Baratta, Francesco; Pastori, Daniele] Sapienza Univ, Dept Internal Med & Med Specialties, Rome, Italy.
   [Polimeni, Licia; Baratta, Francesco; Pastori, Daniele] Sapienza Univ, Dept Anat Histol Forens Med & Orthoped Sci, Rome, Italy.
   [Angelico, Francesco] Sapienza Univ, Dept Publ Hlth & Infect Dis, Rome, Italy.
C3 Sapienza University Rome; Sapienza University Rome; Sapienza University
   Rome
RP Angelico, F (corresponding author), Sapienza Univ Rome, Viale Policlin 155, I-00161 Rome, Italy.
EM francesco.angelico@uniroma1.it
RI Del Ben, Maria/AAE-7603-2020; Angelico, Francesco/AAB-6585-2020;
   pastori, daniele/J-7087-2016
OI pastori, daniele/0000-0001-6357-5213; Baratta,
   Francesco/0000-0003-1708-272X
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NR 68
TC 65
Z9 67
U1 2
U2 37
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0306-5251
EI 1365-2125
J9 BRIT J CLIN PHARMACO
JI Br. J. Clin. Pharmacol.
PD JAN
PY 2017
VL 83
IS 1
SI SI
BP 88
EP 95
DI 10.1111/bcp.12899
PG 8
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA EK4KD
UT WOS:000393894600011
PM 26852185
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Westerink, J
   Olijhoek, JK
   Koppen, A
   Faber, DR
   Kalkhoven, E
   Monajemi, H
   van Asbeck, BS
   van der Graaf, Y
   Visseren, FLJ
AF Westerink, Jan
   Olijhoek, Jobien K.
   Koppen, Arjen
   Faber, Daniel R.
   Kalkhoven, Eric
   Monajemi, Houshang
   van Asbeck, B. Sweder
   van der Graaf, Yolanda
   Visseren, Frank L. J.
TI The relation between body iron stores and adipose tissue function in
   patients with manifest vascular disease
SO EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
LA English
DT Article
DE Adipocytes; adiponectin; adipose tissue function; iron; obesity
ID INSULIN-RESISTANCE; METABOLIC SYNDROME; SERUM FERRITIN; OXIDATIVE
   STRESS; ADIPONECTIN; INFLAMMATION; TRANSFERRIN; OBESITY;
   RETINOL-BINDING-PROTEIN-4; DEFICIENCY
AB BackgroundWe investigated whether plasma ferritin levels through the pro-inflammatory effects of free iron are associated with adipose tissue dysfunction in a relevant population of patients with manifest vascular disease who would potentially benefit the most from further aetiological insights.
   Materials and methodsIn a cohort of 355 patients with vascular diseases, the association between plasma ferritin and adiponectin levels was quantified using linear regression analysis. Interleukin-6 and adiponectin levels were measured in medium from pre-adipocytes and adipocytes after incubation with increasing concentrations of Fe(III)-citrate and after co-incubation with iron chelators or radical scavengers.
   ResultsIncreasing ferritin plasma concentrations were not related to plasma adiponectin levels in patients without ( -013; 95% CI -030 to 004) or with the metabolic syndrome ( -004; 95% CI -017 to 010). Similar results were found in patients who developed a new cardiovascular event in the follow-up period. In vitro, incubation with increasing concentrations of Fe(III)-citrate-induced inflammation in pre-adipocyte cultures as witnessed by increased IL-6 secretion at 30m Fe(III)-citrate vs. control (50098pg/mL vs. 194 +/- 31pg/mL, P=003). Co-incubation of pre-adipocytes with iron chelators or radical scavengers prevented this inflammatory response. Incubation of adipocytes with 30m Fe(III)-citrate did not influence adiponectin secretion compared with control.
   ConclusionsIn patients with vascular disease, there is no association between plasma ferritin and adiponectin levels. In vitro, free iron induces an inflammatory response in pre-adipocytes, but not in adipocytes. This response was blocked by co-incubation with iron chelators or radical scavengers. Adiponectin secretion by adipocytes was not influenced by free iron.
C1 [Westerink, Jan; Faber, Daniel R.; Monajemi, Houshang; Visseren, Frank L. J.] Univ Med Ctr Utrecht, Dept Vasc Med, NL-3508 GA Utrecht, Netherlands.
   [Olijhoek, Jobien K.] Tweesteden Hosp, Dept Vasc Med, Tilburg, Netherlands.
   [Koppen, Arjen; Kalkhoven, Eric] Univ Med Ctr Utrecht, Dept Metab Dis, NL-3508 GA Utrecht, Netherlands.
   [van Asbeck, B. Sweder] Univ Med Ctr Utrecht, Dept Internal Med, NL-3508 GA Utrecht, Netherlands.
   [van der Graaf, Yolanda] Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands.
C3 Utrecht University; Utrecht University Medical Center;
   Elisabeth-TweeSteden Ziekenhuis (ETZ); Utrecht University; Utrecht
   University Medical Center; Utrecht University; Utrecht University
   Medical Center
RP Visseren, FLJ (corresponding author), Univ Med Ctr Utrecht, Dept Vasc Med, POB 85500, NL-3508 GA Utrecht, Netherlands.
EM F.L.J.Visseren@umcutrecht.nl
RI Koppen, Arjen/GLV-6743-2022; van der Kaaij, Niels/LJK-9624-2024;
   Visseren, Frank/I-4855-2013; Westerink, Jan/AAO-7725-2021
OI Visseren, Frank/0000-0003-3951-5223
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NR 43
TC 5
Z9 5
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0014-2972
EI 1365-2362
J9 EUR J CLIN INVEST
JI Eur. J. Clin. Invest.
PD DEC
PY 2013
VL 43
IS 12
BP 1240
EP 1249
DI 10.1111/eci.12165
PG 10
WC Medicine, General & Internal; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Research & Experimental Medicine
GA 295FL
UT WOS:000330101900002
PM 24245570
OA Bronze
DA 2025-06-11
ER

PT J
AU Rossi, AM
   Davies, E
   Lavoie, KL
   Arsenault, A
   Gordon, JL
   Meloche, B
   Bacon, SL
AF Rossi, Amanda M.
   Davies, Elaine
   Lavoie, Kim L.
   Arsenault, Andre
   Gordon, Jennifer L.
   Meloche, Bernard
   Bacon, Simon L.
TI The Impact of Metabolic Syndrome and Endothelial Dysfunction on
   Exercise-Induced Cardiovascular Changes
SO OBESITY
LA English
DT Article
ID SYMPATHETIC-NERVOUS-SYSTEM; HEART-RATE; AUTONOMIC FUNCTION; OBESITY;
   VARIABILITY; SENSITIVITY
AB Objective: There is limited information regarding the synergistic or additive effects of metabolic syndrome (MS) and endothelial dysfunction (ED) on cardiovascular disease (CVD). Altered cardiovascular responses to exercise have been shown to predict future cardiovascular events as well as assess autonomic function. The present study evaluated the impact of MS and brachial artery reactivity (a proxy of ED) on peak exercise-induced cardiovascular changes.
   Design and Methods: Individuals (n = 303) undergoing a standard nuclear medicine exercise stress test were assessed for MS. Participants underwent a Forearm Hyperaemic Reactivity test and were considered to have dysfunctional reactivity if their rate of uptake ratio (RUR) was <3.55. Resting and peak blood pressure (BP) and heart rate (HR) were measured. Reactivity was calculated as the difference between peak and resting measures.
   Results: Analyses, adjusting for age, sex, resting HR, total metabolic equivalents (METs), and a history of major CVD, revealed a main effect of MS (F = 5.51, eta(2) - 0.02, P - 0.02) and RUR (F - 6.69, eta(2) - 0.02, P = 0.01) on HR reactivity, such that patients with MS and/or poor RUR had reduced HR reactivity. There were no interactive effects of RUR and MS. There were no effects of RUR or MS on systolic BP (SBP) or diastolic BP (DBP) reactivity or rate pressure product (RPP) reactivity.
   Conclusions: The presence of decreased HR reactivity among participants with MS or poor brachial artery reactivity, combined with the lack of difference in other exercise-induced cardiovascular changes, indicates that these patients may have some degree of parasympathetic dysregulation. Further longitudinal studies are needed to understand the long-term implications of MS and endothelial abnormalities in this context.
C1 [Rossi, Amanda M.; Davies, Elaine; Lavoie, Kim L.; Arsenault, Andre; Gordon, Jennifer L.; Meloche, Bernard; Bacon, Simon L.] Montreal Behav Med Ctr, Montreal, PQ, Canada.
   [Rossi, Amanda M.; Davies, Elaine; Lavoie, Kim L.; Arsenault, Andre; Gordon, Jennifer L.; Meloche, Bernard; Bacon, Simon L.] Montreal Heart Inst, Res Ctr, Montreal, PQ H1T 1C8, Canada.
   [Rossi, Amanda M.; Davies, Elaine; Bacon, Simon L.] Concordia Univ, Dept Exercise Sci, Montreal, PQ, Canada.
   [Lavoie, Kim L.; Bacon, Simon L.] Hop Sacre Coeur Montreal, Res Ctr, Montreal, PQ, Canada.
   [Lavoie, Kim L.] Univ Montreal, Dept Psychol, Montreal, PQ H3C 3J7, Canada.
   [Gordon, Jennifer L.] McGill Univ, Dept Psychol, Montreal, PQ, Canada.
C3 Universite de Montreal; Universite de Montreal; Concordia University -
   Canada; Universite de Montreal; Universite de Montreal; McGill
   University
RP Bacon, SL (corresponding author), Montreal Behav Med Ctr, Montreal, PQ, Canada.
EM simon.bacon@concordia.ca
RI Lavoie, Kim/J-8969-2014; Bacon, Simon/B-2637-2012
OI Bacon, Simon/0000-0001-7075-0358; Lavoie, Kim/0000-0003-2606-1357
FU Canadian Institutes of Health Research (CIHR: MOP); Heart and Stroke
   Foundation of Canada; Fonds de la Recherche en Sante du Quebec (FRSQ);
   CIHR; Vanier Canada Graduate Scholarship (CIHR)
FX The authors would like to acknowledge operating funding support from the
   Canadian Institutes of Health Research (CIHR: MOP) and the Heart and
   Stroke Foundation of Canada, and new investigator funding from Fonds de
   la Recherche en Sante du Quebec (FRSQ: for S.L.B. and K.L.L.), CIHR (for
   S.L.B.), and the Vanier Canada Graduate Scholarship (CIHR: for A.M.R.
   and J.L.G.).
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NR 40
TC 2
Z9 2
U1 0
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1930-7381
EI 1930-739X
J9 OBESITY
JI Obesity
PD JAN
PY 2013
VL 21
IS 1
BP E143
EP E148
DI 10.1002/oby.20258
PG 6
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 187AE
UT WOS:000322086900021
PM 23505196
DA 2025-06-11
ER

PT J
AU Shpilberg, Y
   Beaudry, JL
   D'Souza, A
   Campbell, JE
   Peckett, A
   Riddell, MC
AF Shpilberg, Yaniv
   Beaudry, Jacqueline L.
   D'Souza, Anna
   Campbell, Jonathan E.
   Peckett, Ashley
   Riddell, Michael C.
TI A rodent model of rapid-onset diabetes induced by glucocorticoids and
   high-fat feeding
SO DISEASE MODELS & MECHANISMS
LA English
DT Article
ID BLOOD-GLUCOSE CONCENTRATION; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   INDUCED OBESITY; RAT; DEXAMETHASONE; STRESS; MUSCLE; HOMEOSTASIS;
   PREVENTION
AB Glucocorticoids (GCs) are potent pharmacological agents used to treat a number of immune conditions. GCs are also naturally occurring steroid hormones (e. g. cortisol, corticosterone) produced in response to stressful conditions that are thought to increase the preference for calorie dense 'comfort' foods. If chronically elevated, GCs can contribute to the development of type 2 diabetes mellitus (T2DM), although the mechanisms for the diabetogenic effects are not entirely clear. The present study proposes a new rodent model to investigate the combined metabolic effects of elevated GCs and high-fat feeding on ectopic fat deposition and diabetes development. Male Sprague-Dawley rats (aged 7-8 weeks) received exogenous corticosterone or wax (placebo) pellets, implanted subcutaneously, and were fed either a standard chow diet (SD) or a 60% high-fat diet (HFD) for 16 days. Animals given corticosterone and a HFD (cort-HFD) had lower body weight and smaller relative glycolytic muscle mass, but increased relative epididymal mass, compared with controls (placebo-SD). Cort-HFD rats exhibited severe hepatic steatosis and increased muscle lipid deposition compared with placebo-SD animals. Moreover, cort-HFD animals were found to exhibit severe fasting hyperglycemia (60% increase), hyperinsulinemia (80% increase), insulin resistance (60% increase) and impaired. -cell response to oral glucose load (20% decrease) compared with placebo-SD animals. Thus, a metabolic syndrome or T2DM phenotype can be rapidly induced in young Sprague-Dawley rats by using exogenous GCs if a HFD is consumed. This finding might be valuable in examining the physiological and molecular mechanisms of GC-induced metabolic disease.
C1 [Shpilberg, Yaniv; Beaudry, Jacqueline L.; D'Souza, Anna; Campbell, Jonathan E.; Peckett, Ashley; Riddell, Michael C.] York Univ, Toronto, ON M3J 1P3, Canada.
C3 York University - Canada
RP Riddell, MC (corresponding author), York Univ, 4700 Keele St, Toronto, ON M3J 1P3, Canada.
EM mriddell@yorku.ca
OI Campbell, Jonathan/0000-0001-8223-1600
FU Natural Sciences and Engineering Research Council of Canada [261306];
   Canadian Diabetes Association [OG-09-2904]
FX This work was supported by the Natural Sciences and Engineering Research
   Council of Canada (grant number 261306) and the Canadian Diabetes
   Association (grant number OG-09-2904).
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NR 58
TC 66
Z9 72
U1 0
U2 21
PU COMPANY BIOLOGISTS LTD
PI CAMBRIDGE
PA BIDDER BUILDING, STATION RD, HISTON, CAMBRIDGE CB24 9LF, ENGLAND
SN 1754-8403
EI 1754-8411
J9 DIS MODEL MECH
JI Dis. Model. Mech.
PD SEP
PY 2012
VL 5
IS 5
BP 671
EP 680
DI 10.1242/dmm.008912
PG 10
WC Cell Biology; Medicine, Research & Experimental; Pathology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Research & Experimental Medicine; Pathology
GA 005GB
UT WOS:000308737400016
PM 22184636
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Li, M
   Xu, Y
   Xu, M
   Ma, LY
   Wang, TG
   Liu, Y
   Dai, M
   Chen, YH
   Lu, JL
   Liu, JM
   Bi, YF
   Ning, G
AF Li, Mian
   Xu, Yu
   Xu, Min
   Ma, Lingying
   Wang, Tiange
   Liu, Yu
   Dai, Meng
   Chen, Yuhong
   Lu, Jieli
   Liu, Jianmin
   Bi, Yufang
   Ning, Guang
TI Association between Nonalcoholic Fatty Liver Disease (NAFLD) and
   Osteoporotic Fracture in Middle-Aged and Elderly Chinese
SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Article
ID BONE-MINERAL DENSITY; PRIMARY BILIARY-CIRRHOSIS; METABOLIC SYNDROME;
   OLDER-ADULTS; RISK; WOMEN; MEN; STRESS; COHORT; MASS
AB Context: Nonalcoholic fatty liver disease (NAFLD) has been considered as a hepatic manifestation of the metabolic syndrome and is associated with various metabolic abnormalities, which may link to an increased risk of osteoporotic fracture. However, epidemiological studies investigating the association between NAFLD and osteoporotic fracture were not available.
   Objective: The objective of the study was to determine whether NAFLD associates with osteoporotic fracture.
   Design, Setting, and Participants: This was a cross-sectional study of 7797 Chinese adults aged 40 yr or older in the Jiading District, Shanghai, China.
   Main Outcome Measures: A questionnaire, anthropometric measurements, laboratory tests, and a hepatic ultrasonic examination were conducted. NAFLD was diagnosed by hepatic ultrasound after the exclusion of alcohol abuse and other liver diseases. A history of fractures was collected with an interviewer-assisted questionnaire. Osteoporotic fractures were defined as fractures that occurred due to low-trauma in 2 yr prior to the study.
   Results: Among men, the prevalence of osteoporotic fractures was significantly higher in those with NAFLD (3.6 vs. 1.7%, P = 0.003); however, no difference was found in women (3.4 vs. 2.6%, P = 0.14). The presence of NAFLD was significantly associated with increased odds of osteoporotic fracture among men (odds ratio 2.53; 95% confidence interval 1.26-5.07; P = 0.009) after controlling for potential confounders. The significant associations were not detected in women.
   Conclusions: The presence of NAFLD was significantly associated with a recent history of osteoporotic fracture in middle-aged and elderly Chinese men. (J Clin Endocrinol Metab 97: 2033-2038, 2012)
C1 [Li, Mian; Xu, Yu; Xu, Min; Ma, Lingying; Wang, Tiange; Liu, Yu; Chen, Yuhong; Lu, Jieli; Liu, Jianmin; Bi, Yufang; Ning, Guang] Shanghai Univ, Dept Endocrinol & Metab, Rui Jin Hosp,Shanghai Jiao Tong Univ,Inst E, Sch Med,Key Lab Endrocrine & Metab Dis,Minist Hlt, Rui Jin 2nd Rd, Shanghai 200025, Peoples R China.
   [Li, Mian; Xu, Yu; Xu, Min; Wang, Tiange; Dai, Meng; Chen, Yuhong; Lu, Jieli; Liu, Jianmin; Bi, Yufang; Ning, Guang] Shanghai Jiao Tong Univ, Shanghai Clin Ctr Endocrine & Metab Dis, Rui Jin Hosp,Shanghai Inst Endocrine & Metab Dis, Sch Med,Inst E Shanghai Univ,Dept Endocrine & Met, Shanghai 200025, Peoples R China.
C3 Shanghai University; Shanghai Jiao Tong University; Shanghai Jiao Tong
   University
RP Bi, YF (corresponding author), Shanghai Univ, Dept Endocrinol & Metab, Rui Jin Hosp,Shanghai Jiao Tong Univ,Inst E, Sch Med,Key Lab Endrocrine & Metab Dis,Minist Hlt, Rui Jin 2nd Rd, Shanghai 200025, Peoples R China.
EM byf10784@rjh.com.cn
RI Liu, Jianmin/KEI-9744-2024; Li, Mian/HGE-6038-2022; Martinez,
   Ramfis/I-7205-2019; Wang, Tiange/MCX-9826-2025; bi, yu/JOK-3859-2023;
   lu, jieli/JJG-0395-2023
OI Wang, Tiange/0000-0003-0723-489X
FU Key Laboratory for Endocrine and Metabolic Diseases of the Ministry of
   Chinese Public Health [1994DP131044]; National Key New Drug Creation and
   Manufacturing Program of the Ministry of Science and Technology
   [2012ZX09303006-001]; Sector Funds of the Ministry of Health
   [201002002]; Creative Research Group of Ministry of Education [IRT0932];
   National Natural Science Foundation of China [81170719, 30900700,
   81100564]; Technology Commission of Shanghai Municipality [10140902900,
   10PJ1408900]
FX This work was supported by the Grant 1994DP131044 from the Key
   Laboratory for Endocrine and Metabolic Diseases of the Ministry of
   Chinese Public Health, Grant 2012ZX09303006-001 from the National Key
   New Drug Creation and Manufacturing Program of the Ministry of Science
   and Technology, Grant 201002002 from the Sector Funds of the Ministry of
   Health, Grant IRT0932 from the Creative Research Group of Ministry of
   Education, Grants 81170719, 30900700, and 81100564 from the National
   Natural Science Foundation of China, and Grants 10140902900 and
   10PJ1408900 from the Technology Commission of Shanghai Municipality.
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NR 33
TC 121
Z9 131
U1 1
U2 16
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0021-972X
EI 1945-7197
J9 J CLIN ENDOCR METAB
JI J. Clin. Endocrinol. Metab.
PD JUN
PY 2012
VL 97
IS 6
BP 2033
EP 2038
DI 10.1210/jc.2011-3010
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 970AP
UT WOS:000306100800056
PM 22466338
OA Bronze
DA 2025-06-11
ER

PT J
AU Karadeniz, M
   Erdogan, M
   Ayhan, Z
   Yalcin, M
   Olukman, M
   Cetinkalp, S
   Alper, GE
   Eroglu, Z
   Tetik, A
   Cetintas, V
   Ozgen, AG
   Saygili, F
   Yilmaz, C
AF Karadeniz, Muammer
   Erdogan, Mehmet
   Ayhan, Zengi
   Yalcin, Murat
   Olukman, Murat
   Cetinkalp, Sevki
   Alper, Gulinnaz E.
   Eroglu, Zuhal
   Tetik, Asli
   Cetintas, Vildan
   Ozgen, Ahmet G.
   Saygili, Fusun
   Yilmaz, Candeger
TI Effect Of G2706A and G1051A polymorphisms of the ABCA1 gene on the
   lipid, oxidative stress and homocystein levels in Turkish patients with
   polycystic ovary syndrome
SO LIPIDS IN HEALTH AND DISEASE
LA English
DT Article
ID CORONARY-ARTERY DISEASE; INSULIN-RESISTANCE; YOUNG-WOMEN; METABOLIC
   SYNDROME; HEART-DISEASE; RISK; PROTEIN; CHOLESTEROL; PREVALENCE; TISSUE
AB Background: Obesity, insulin resistance and hyperandrogenism, crucial parameters of Polycystic ovary syndrome (PCOS) play significant pathophysiological roles in lipidemic aberrations associated within the syndrome. Parts of the metabolic syndrome (low HDL and insulin resistance) appeared to facilitate the association between PCOS and coronary artery disease, independently of obesity. ABCA1 gene polymorphism may be altered this components in PCOS patients.
   In this study, we studied 98 PCOS patients and 93 healthy controls. All subjects underwent venous blood drawing for complete hormonal assays, lipid profile, glucose, insulin, malondialdehyde, nitric oxide, disulfide levels and ABCA genetic study.
   Results: In PCOS group fasting glucose, DHEAS, 17-OHP, free testosterone, total-cholesterol, triglyceride, LDL-cholesterol and fibrinogen were significantly different compare to controls. The genotype ABCA G2706A distribution differed between the control group (GG 60.7%, GA 32.1%, AA 7.1%) and the PCOS patients (GG 8.7%, GA 8.7%, AA 76.8%). The frequency of the A allele (ABCAG2706A) was higher in PCOS patients than control group with 13,0% and 23,2%, respectively. In this study, the homocystein and insulin levels were significantly higher in PCOS patients with ABCA G1051A mutant genotype than those with heterozygote and wild genotypes.
   Conclusions: We found higher percentage of AA genotype and A allele of ABCA G2706A in PCOS patients compare to controls. The fasting insulin and homocystein levels were significantly higher in PCOS patients with ABCA G1051A mutant genotype than those with heterozygote and wild genotypes.
C1 [Karadeniz, Muammer] Sifa Univ, Dept Endocrinol, Hlth Applicat & Res Ctr, Izmir, Turkey.
   [Erdogan, Mehmet; Ayhan, Zengi; Cetinkalp, Sevki; Saygili, Fusun; Yilmaz, Candeger] Ege Univ, Dept Endocrinol, Sch Med, Izmir, Turkey.
   [Alper, Gulinnaz E.] Ege Univ, Dept Biochem, Sch Med, Izmir, Turkey.
   [Eroglu, Zuhal; Tetik, Asli; Cetintas, Vildan] Ege Univ, Dept Med Biol, Sch Med, Izmir, Turkey.
   [Olukman, Murat] Ege Univ, Ege Univ Hosp, Sch Med, Dept Pharmacol, Izmir, Turkey.
   [Olukman, Murat] Sifa Univ, Div Internal Med, Hlth Applicat & Res Ctr, Izmir, Turkey.
C3 Sifa University; Ege University; Ege University; Ege University; Ege
   University; Sifa University
RP Karadeniz, M (corresponding author), Sifa Univ, Dept Endocrinol, Hlth Applicat & Res Ctr, Izmir, Turkey.
EM muammermd@hotmail.com
RI Erdoğan, Mehmet/JAC-5515-2023; Bozok, Vildan/C-2946-2014; OLUKMAN,
   MURAT/Y-4526-2019; Özgen, Ahmet Gökhan/JXW-7839-2024; Tetik Vardarlı,
   Aslı/HHD-1028-2022; karadeniz, muammer/L-8819-2013; Saygili,
   Fusun/LRT-0435-2024
OI Olukman, Murat/0000-0002-9868-4716; Bozok, Vildan/0000-0003-3915-6363;
   Tetik Vardarli, Asli/0000-0001-9890-3256
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NR 37
TC 17
Z9 21
U1 0
U2 28
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1476-511X
J9 LIPIDS HEALTH DIS
JI Lipids Health Dis.
PD OCT 28
PY 2011
VL 10
AR 193
DI 10.1186/1476-511X-10-193
PG 8
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA 849EQ
UT WOS:000297108800002
PM 22035022
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Frisardi, V
   Solfrizzi, V
   Capurso, C
   Imbimbo, BP
   Vendemiale, G
   Seripa, D
   Pilotto, A
   Panza, F
AF Frisardi, Vincenza
   Solfrizzi, Vincenzo
   Capurso, Cristiano
   Imbimbo, Bruno P.
   Vendemiale, Gianluigi
   Seripa, Davide
   Pilotto, Alberto
   Panza, Francesco
TI Is Insulin Resistant Brain State a Central Feature of the
   Metabolic-Cognitive Syndrome?
SO JOURNAL OF ALZHEIMERS DISEASE
LA English
DT Article
DE Amyloid-beta peptide metabolism; hyperinsulinemia; hyperphosphorylated
   tau protein; insulin resistance; insulin resistant brain state;
   metabolic syndrome; type 2 diabetes mellitus
ID SPORADIC ALZHEIMERS-DISEASE; TYPE-2 DIABETES-MELLITUS; GROWTH-FACTOR
   EXPRESSION; CENTRAL-NERVOUS-SYSTEM; VASCULAR RISK-FACTORS;
   TAU-PHOSPHORYLATION; PROVISIONAL REPORT; DEGRADING ENZYME; DEMENTIA;
   POPULATION
AB Cumulative evidence suggests that metabolic syndrome (MetS) may be important in the development of mild cognitive impairment, vascular dementia, and Alzheimer's disease (AD). As such, these patients might be described as having "metabolic-cognitive syndrome" - MetS plus cognitive impairment of degenerative or vascular origin. While peripheral insulin resistance appears to be of primary pathophysiological importance in MetS, the definitions of MetS and its components do not include any reference to insulin resistance or hyperinsulinemia. In the present article, we discuss the role of these factors in the development of cognitive decline and dementia, including underlying mechanisms that influence amyloid-beta (A beta) peptide metabolism and tau protein hyperphosphorylation, the principal neuropathological hallmarks of AD. In AD, an age-related desynchronization of biological systems results, involving stress components, cortisol and noradrenaline, reactive oxygen species, and membrane damage as major candidates that precipitates an insulin resistant brain state (IRBS) with decreased glucose/energy metabolism and the increased formation of hyperphosphorylated tau protein and A beta. Unfortunately, it is very difficult to include the measurement of peripheral insulin resistance in the current MetS criteria or the identification of IRBS for the metabolic-cognitive syndrome. However, since inflammation has been suggested among the MetS components, we propose IRBS as an additional feature of the metabolic-cognitive syndrome to also identify a molecular profile in patients at high risk of developing predementia or dementia syndromes.
C1 [Frisardi, Vincenza; Solfrizzi, Vincenzo] Univ Bari, Dept Geriatr, Ctr Aging Brain, Memory Unit, I-70124 Bari, Italy.
   [Capurso, Cristiano; Vendemiale, Gianluigi] Univ Foggia, Dept Geriatr, Foggia, Italy.
   [Imbimbo, Bruno P.] Chiesi Farmaceut, Dept Res & Dev, Parma, Italy.
   [Seripa, Davide; Pilotto, Alberto; Panza, Francesco] IRCCS Casa Sollievo Sofferenza, Geriatr Unit, I-71013 Foggia, Italy.
   [Seripa, Davide; Pilotto, Alberto; Panza, Francesco] IRCCS Casa Sollievo Sofferenza, Gerontol Geriatr Res Lab, Dept Med Sci, I-71013 Foggia, Italy.
C3 Universita degli Studi di Bari Aldo Moro; University of Foggia; Chiesi
   Pharmaceuticals Inc; IRCCS Casa Sollievo Della Sofferenza; IRCCS Casa
   Sollievo Della Sofferenza
RP Frisardi, V (corresponding author), Univ Bari, Dept Geriatr, Ctr Aging Brain, Memory Unit, Piazza Giulio Cesare 11, I-70124 Bari, Italy.
EM vfrisardi@yahoo.com; geriat.dot@geriatria.uniba.it
RI Seripa, Davide/AAK-1342-2021; solfrizzi, vincenzo/AAL-3222-2020;
   frisardi, vincenza/Y-3309-2019; Panza, Francesco/Y-2539-2019; Imbimbo,
   Bruno/E-2471-2013; Panza, Francesco/M-6804-2017; Capurso,
   Cristiano/AAC-1683-2019; Seripa, Davide/B-9408-2017
OI Imbimbo, Bruno/0000-0002-0327-7262; frisardi,
   vincenza/0000-0003-0764-7387; Panza, Francesco/0000-0002-7220-0656;
   Capurso, Cristiano/0000-0002-1152-3371; Seripa,
   Davide/0000-0001-7331-0470
FU Italian Longitudinal Study on Aging (ILSA) (Italian National Research
   Council - CNR-Targeted Project on Ageing) [9400419PF40, 95973PF40];
   Ministero della Salute
FX This work was supported by the Italian Longitudinal Study on Aging
   (ILSA) (Italian National Research Council - CNR-Targeted Project on
   Ageing - Grants 9400419PF40 and 95973PF40) and Ministero della Salute,
   IRCCS Research Program 2009-2011, Line 2: "Malattie complesse".
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NR 68
TC 73
Z9 79
U1 0
U2 9
PU IOS PRESS
PI AMSTERDAM
PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS
SN 1387-2877
EI 1875-8908
J9 J ALZHEIMERS DIS
JI J. Alzheimers Dis.
PY 2010
VL 21
IS 1
BP 57
EP 63
DI 10.3233/JAD-2010-100015
PG 7
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 629XW
UT WOS:000280235500005
PM 20421697
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Hayden, MR
   Tyagi, SC
   Kolb, L
   Sowers, JR
   Khanna, R
AF Hayden, Melvin R.
   Tyagi, Suresh C.
   Kolb, Lisa
   Sowers, James R.
   Khanna, Ramesh
TI Vascular ossification - calcification in metabolic syndrome, type 2
   diabetes mellitus, chronic kidney disease, and calciphylaxis - calcific
   uremic arteriolopathy: the emerging role of sodium thiosulfate
SO CARDIOVASCULAR DIABETOLOGY
LA English
DT Review
ID MEDIAL ARTERIAL CALCIFICATION; CARDIOVASCULAR-DISEASE; SKIN NECROSIS;
   REDOX STRESS; BONE; ATHEROSCLEROPATHY; ASSOCIATION; HYPERGLYCEMIA;
   NANOBACTERIA; DETERMINANTS
AB Background: Vascular calcification is associated with metabolic syndrome, diabetes, hypertension, atherosclerosis, chronic kidney disease, and end stage renal disease. Each of the above contributes to an accelerated and premature demise primarily due to cardiovascular disease. The above conditions are associated with multiple metabolic toxicities resulting in an increase in reactive oxygen species to the arterial vessel wall, which results in a response to injury wound healing (remodeling). The endothelium seems to be at the very center of these disease processes, acting as the first line of defense against these multiple metabolic toxicities and the first to encounter their damaging effects to the arterial vessel wall.
   Results: The pathobiomolecular mechanisms of vascular calcification are presented in order to provide the clinician - researcher a database of knowledge to assist in the clinical management of these high-risk patients and examine newer therapies. Calciphylaxis is associated with medial arteriolar vascular calcification and results in ischemic subcutaneous necrosis with vulnerable skin ulcerations and high mortality. Recently, this clinical syndrome (once thought to be rare) is presenting with increasing frequency. Consequently, newer therapeutic modalities need to be explored. Intravenous sodium thiosulfate is currently used as an antidote for the treatment of cyanide poisioning and prevention of toxicities of cisplatin cancer therapies. It is used as a food and medicinal preservative and topically used as an antifungal medication.
   Conclusion: A discussion of sodium thiosulfate's dual role as a potent antioxidant and chelator of calcium is presented in order to better understand its role as an emerging novel therapy for the clinical syndrome of calciphylaxis and its complications.
C1 [Hayden, Melvin R.] Univ Missouri Columbia, Dept Family & Community Med, Camdenton, MO 65020 USA.
   [Tyagi, Suresh C.] Univ Louisville, Dept Physiol & Biophys, Louisville, KY 40292 USA.
   [Kolb, Lisa] Capital City Med Associates, Jefferson City, MO 65109 USA.
   [Sowers, James R.; Khanna, Ramesh] Univ Missouri, Sch Med, Hlth Sci Ctr, Dept Internal Med, Columbia, MO 65212 USA.
C3 University of Missouri System; University of Missouri Columbia;
   University of Louisville; University of Missouri System; University of
   Missouri Columbia
RP Hayden, MR (corresponding author), Univ Missouri Columbia, Dept Family & Community Med, Missouri POB 1140 Lk Rd 5-87, Camdenton, MO 65020 USA.
EM mrh29@usmo.com; s0tyagi01@louisville.edu; asommerer-ccma@earthlink.net;
   sowersj@health.missouri.edu; khannar@health.missouri.edu
FU National Institutes of Health; National Kidney Foundation; National
   Institute of Diabetes, Digestive, and Kidney Diseases
FX The authors would like to acknowledge the brave heroes who live to be
   dialyzed and undergo dialysis to live. Additionally, we acknowledge all
   the brave scientists and clinicians who have made renal replacement
   possible for these people requiring treatment for ESRD. We also wish to
   acknowledge The National Institutes of Health, The National Kidney
   Foundation, and The National Institute of Diabetes, Digestive, and
   Kidney Diseases for their generous time and grants, which make this type
   of research possible for the public at large. We wish to thank those who
   have been organ donors.
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NR 88
TC 169
Z9 192
U1 0
U2 15
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1475-2840
J9 CARDIOVASC DIABETOL
JI Cardiovasc. Diabetol.
PY 2005
VL 4
AR 4
DI 10.1186/1475-2840-4-4
PG 22
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism
GA V23DD
UT WOS:000208322600004
PM 15777477
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Zhang, JW
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   Zhu, LY
   Li, YJ
   Yu, H
   Du, LH
   Fan, DS
   Deng, BB
AF Zhang, Junwei
   Cao, Wen
   Xie, Jiali
   Pang, Chunyang
   Gao, Lingfei
   Zhu, Luyi
   Li, Yaojia
   Yu, Huan
   Du, Lihuai
   Fan, Dongsheng
   Deng, Binbin
TI Metabolic Syndrome and Risk of Amyotrophic Lateral Sclerosis: Insights
   from a Large-Scale Prospective Study
SO ANNALS OF NEUROLOGY
LA English
DT Article
ID DIABETES-MELLITUS; OXIDATIVE STRESS; EXTENDS SURVIVAL; L-CARNITINE;
   POPULATION; DISEASE; ALS; HYPERTENSION; HOMEOSTASIS; PROGRESSION
AB Objective: Although metabolic abnormalities are implicated in the etiology of neurodegenerative diseases, their role in the development of amyotrophic lateral sclerosis (ALS) remains a subject of controversy. We aimed to identify the association between metabolic syndrome (MetS) and the risk of ALS. Methods: This study included 395,987 participants from the UK Biobank to investigate the relationship between MetS and ALS. Cox regression model was used to estimate hazard ratios (HR). Stratified analyses were performed based on gender, body mass index (BMI), smoking status, and education level. Mediation analysis was conducted to explore potential mechanisms. Results: In this study, a total of 539 cases of ALS were recorded after a median follow-up of 13.7 years. Patients with MetS (defined harmonized) had a higher risk of developing ALS after adjusting for confounding factors (HR: 1.50, 95% CI: 1.19-1.89). Specifically, hypertension and high triglycerides were linked to a higher risk of ALS (HR: 1.53, 95% CI: 1.19-1.95; HR: 1.31, 95% CI: 1.06-1.61, respectively). Moreover, the quantity of metabolic abnormalities showed significant results. Stratified analysis revealed that these associations are particularly significant in individuals with a BMI <25. These findings remained stable after sensitivity analysis. Notably, mediation analysis identified potential metabolites and metabolomic mediators, including alkaline phosphatase, cystatin C, gamma-glutamyl transferase, saturated fatty acids to total fatty acids percentage, and omega-6 fatty acids to omega-3 fatty acids ratio. Interpretation: MetS exhibits a robust association with an increased susceptibility to ALS, particularly in individuals with a lower BMI. Furthermore, metabolites and metabolomics, as potential mediators, provide invaluable insights into the intricate biological mechanisms. ANN NEUROL 2024
C1 [Zhang, Junwei; Xie, Jiali; Pang, Chunyang; Gao, Lingfei; Zhu, Luyi; Li, Yaojia; Deng, Binbin] Wenzhou Med Univ, Affiliated Hosp 1, Dept Neurol, Wenzhou 325000, Zhejiang, Peoples R China.
   [Zhang, Junwei; Deng, Binbin] Wenzhou Med Univ, Affiliated Hosp 1, Zhejiang Key Lab Intelligent Canc Biomarker Discov, Wenzhou, Peoples R China.
   [Cao, Wen; Fan, Dongsheng] Peking Univ Third Hosp, Dept Neurol, Beijing, Peoples R China.
   [Cao, Wen; Fan, Dongsheng] Beijing Key Lab Biomarker & Translat Res Neurodeg, Beijing, Peoples R China.
   [Cao, Wen; Fan, Dongsheng] Peking Univ, Key Lab Neurosci, Natl Hlth Commiss, Minist Educ, Beijing, Peoples R China.
   [Xie, Jiali] Tongji Univ, Sch Med, Shanghai East Hosp, Dept Neurol, Shanghai, Peoples R China.
   [Yu, Huan] Wenzhou Med Univ, Affiliated Hosp & Yuying Childrens Hosp 2, Dept Pediat, Wenzhou, Peoples R China.
   [Du, Lihuai] Wenzhou Univ, Coll Math & Phys, Wenzhou, Peoples R China.
C3 Wenzhou Medical University; Wenzhou Medical University; Peking
   University; Peking University; Ministry of Education - China; Tongji
   University; Wenzhou Medical University; Wenzhou University
RP Deng, BB (corresponding author), Wenzhou Med Univ, Affiliated Hosp 1, Dept Neurol, Wenzhou 325000, Zhejiang, Peoples R China.; Fan, DS (corresponding author), Peking Univ Third Hosp, Neurol Dept, 49 North Garden Rd, Beijing 100191, Peoples R China.
EM dsfan2010@aliyun.com; dbinbin@aliyun.com
RI Yu, Huanyun/M-5434-2018
FU National Natural Science Foundation of China [81901273, 12101460];
   Natural Science Foundation of Zhejiang Province [ZCLY24H0903,
   LQ22A010005, LQ22H020003, LQ21H090018]
FX This research was supported by the National Natural Science Foundation
   of China (81901273, 12101460) and the Natural Science Foundation of
   Zhejiang Province (ZCLY24H0903, LQ22A010005, LQ22H020003, and
   LQ21H090018). This study has been conducted using the UK-Biobank
   Resource under application number 108832. The Ethical Decision Committee
   of the Research Administration at First Affiliated Hospital of Wenzhou
   Medical University approved the study (KY2024-R054).
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NR 74
TC 1
Z9 1
U1 3
U2 8
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0364-5134
EI 1531-8249
J9 ANN NEUROL
JI Ann. Neurol.
PD OCT
PY 2024
VL 96
IS 4
BP 788
EP 801
DI 10.1002/ana.27019
EA JUN 2024
PG 14
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA L1R1T
UT WOS:001256094300001
PM 38934512
DA 2025-06-11
ER

PT J
AU Park, JE
   Mun, S
   Lee, S
AF Park, Ji-Eun
   Mun, Sujeong
   Lee, Siwoo
TI Metabolic Syndrome Prediction Models Using Machine Learning and Sasang
   Constitution Type
SO EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Article
ID RISK PREDICTION; IDENTIFICATION; SENSITIVITY; ASSOCIATION
AB Background. Machine learning may be a useful tool for predicting metabolic syndrome (MetS), and previous studies also suggest that the risk of MetS differs according to Sasang constitution type. The present study investigated the development of MetS prediction models utilizing machine learning methods and whether the incorporation of Sasang constitution type could improve the performance of those prediction models. Methods. Participants visiting a medical center for a health check-up were recruited in 2005 and 2006. Six kinds of machine learning were utilized (K-nearest neighbor, naive Bayes, random forest, decision tree, multilayer perceptron, and support vector machine), as was conventional logistic regression. Machine learning-derived MetS prediction models with and without the incorporation of Sasang constitution type were compared to investigate whether the former would predict MetS with higher sensitivity. Age, sex, education level, marital status, body mass index, stress, physical activity, alcohol consumption, and smoking were included as potentially predictive factors. Results. A total of 750/2,871 participants had MetS. Among the six types of machine learning methods investigated, multiplayer perceptron and support vector machine exhibited the same performance as the conventional regression method, based on the areas under the receiver operating characteristic curves. The naive-Bayes method exhibited the highest sensitivity (0.49), which was higher than that of the conventional regression method (0.39). The incorporation of Sasang constitution type improved the sensitivity of all of the machine learning methods investigated except for the K-nearest neighbor method. Conclusion. Machine learning-derived models may be useful for MetS prediction, and the incorporation of Sasang constitution type may increase the sensitivity of such models.
C1 [Park, Ji-Eun; Mun, Sujeong; Lee, Siwoo] Korea Inst Oriental Med, Future Med Div, Daejeon, South Korea.
C3 Korea Institute of Oriental Medicine (KIOM)
RP Lee, S (corresponding author), Korea Inst Oriental Med, Future Med Div, Daejeon, South Korea.
EM bfree@kiom.re.kr
RI Lee, Jong-Young/M-6319-2013; Park, JIeun/KIL-1557-2024
OI Park, Ji-Eun/0000-0002-2932-5373; Mun, Sujeong/0000-0002-3573-8916
FU Korean Genome and Epidemiology Study [KoGES: 4851-302]; Korea Institute
   of Oriental Medicine [KSN2021120]; National Research Council of Science
   & Technology (NST), Republic of Korea [KSN2021120] Funding Source: Korea
   Institute of Science & Technology Information (KISTI), National Science
   & Technology Information Service (NTIS)
FX The authors acknowledge the Korean Genome and Epidemiology Study for
   providing data (KoGES: 4851-302). This research was supported by the
   Korea Institute of Oriental Medicine (KSN2021120).
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NR 37
TC 13
Z9 13
U1 2
U2 14
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1741-427X
EI 1741-4288
J9 EVID-BASED COMPL ALT
JI Evid.-based Complement Altern. Med.
PD FEB 9
PY 2021
VL 2021
AR 8315047
DI 10.1155/2021/8315047
PG 7
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA QM5QH
UT WOS:000621833300004
PM 33628316
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Lanzi, CR
   Perdicaro, DJ
   Antoniolli, A
   Fontana, AR
   Miatello, RM
   Bottini, R
   Prieto, MAV
AF Lanzi, Cecilia Rodriguez
   Perdicaro, Diahann Jeanette
   Antoniolli, Andrea
   Fontana, Ariel Ramn
   Miatello, Roberto Miguel
   Bottini, Ruben
   Vazquez Prieto, Marcela Alejandra
TI Grape pomace and grape pomace extract improve insulin signaling in
   high-fat-fructose fed rat-induced metabolic syndrome
SO FOOD & FUNCTION
LA English
DT Article
ID OXIDATIVE STRESS; DIETARY FIBER; ANTIOXIDANT ACTIVITY; VITIS-VINIFERA;
   INFLAMMATION; OBESITY; RESISTANCE; POLYPHENOLS; RED; EXPRESSION
AB In this study the effect of diet supplementation with grape pomace (GP) and grape pomace extract (GPE) on insulin sensitive tissues (adipose, liver and muscle) was evaluated in an experimental model of metabolic syndrome (MetS). MetS was developed by giving a high-fat-fructose (HFF) diet to Wistar rats. Six weeks of HFF diet induced weight gain, which was partially attenuated by GP (1 g per kg per day) and GPE (300 mg per kg per day) supplementation. HFF diet increased systolic blood pressure, triglycerides, insulin resistance(HOMA:IR) and inflammation (c-reactive protein (CRP)). Supplementation with GP prevented SBP, triglycerides and CRP increased and partially attenuated insulin resistance. On the other hand, GPE partially reduced SBP and triglycerides and significantly prevented insulin resistance and inflammation. Also, HFF diet induced higher triglycerides content and enhanced NADPH oxidase activity in the liver. Also, HFF diet increased the epididymal adipose tissue weight, enlarged adipocyte size, and c-jun N-terminal kinase (JNK) activation, probably contributing to a pro-inflammatory cytokine pattern (higher resistin) and lower adiponectin protein expression. These alterations may result in an impairment of insulin signaling cascade observed in adipose, liver and muscle tissue (IRS1, Akt, and extracellular signal-regulated kinases (ERK1/2)) from HFF rats. Supplementation with GP and to a greater extent GPE attenuated liver triglyceride content and adiposity and restored adipose, liver and muscle response to insulin. These findings show that supplementation with GP and GPE to a greater extent can counteract adiposity, inflammation, liver damage and impaired insulin signaling associated to MetS, supporting the utilization of winemaking residues in food industry/human health due to their high amount of bioactive compounds.
C1 [Lanzi, Cecilia Rodriguez; Perdicaro, Diahann Jeanette; Miatello, Roberto Miguel; Vazquez Prieto, Marcela Alejandra] Univ Nacl Cuyo, Fac Ciencias Med, Area Fisiopatol, Ave Libertador 80,M5502JMA, RA-5500 Mendoza, Argentina.
   [Lanzi, Cecilia Rodriguez; Perdicaro, Diahann Jeanette; Miatello, Roberto Miguel; Vazquez Prieto, Marcela Alejandra] Consejo Nacl Invest Cient & Tecn, Inst Med & Biol Expt Cuyo, Ave Libertador 80,M5502JMA, Mendoza, Argentina.
   [Antoniolli, Andrea; Fontana, Ariel Ramn; Bottini, Ruben] Univ Nacl Cuyo, Consejo Nacl Invest Cient & Tecn, Fac Ciencias Agr, Lab Bioquim Vegetal,Inst Biol Agr Mendoza, Alte Brown 500,M5528AHB, Chacras De Coria, Argentina.
C3 University Nacional Cuyo Mendoza; Consejo Nacional de Investigaciones
   Cientificas y Tecnicas (CONICET); Consejo Nacional de Investigaciones
   Cientificas y Tecnicas (CONICET); University Nacional Cuyo Mendoza
RP Prieto, MAV (corresponding author), Univ Nacl Cuyo, Fac Ciencias Med, Area Fisiopatol, Ave Libertador 80,M5502JMA, RA-5500 Mendoza, Argentina.; Prieto, MAV (corresponding author), Consejo Nacl Invest Cient & Tecn, Inst Med & Biol Expt Cuyo, Ave Libertador 80,M5502JMA, Mendoza, Argentina.
EM mvazquez@fcm.uncu.edu.ar
RI Prieto, Marcela/W-4291-2019; Fontana, Ariel/AAU-9357-2021; Bottini,
   Rubén/AAS-9320-2021
OI Fontana, Ariel/0000-0002-8481-1219; Bottini, Ruben/0000-0002-8896-1476;
   Rodriguez Lanzi, Maria Cecilia/0000-0002-4878-0427; Antoniolli,
   Andrea/0009-0007-6269-9856
FU Programa I+D UNCUYO; PIP CONICET;  [PICT 2013-1856];  [PICT 2014-0547]
FX This work was supported by Programa I+D 2015 UNCUYO; PICT 2013-1856 to
   R. B.; PIP CONICET to M. V. P and R. M. M, and PICT 2014-0547 to M.V.P.
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NR 43
TC 46
Z9 46
U1 3
U2 21
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PY 2016
VL 7
IS 3
BP 1544
EP 1553
DI 10.1039/c5fo01065a
PG 10
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA DG7FZ
UT WOS:000372251500032
PM 26901521
OA Green Published
DA 2025-06-11
ER

PT J
AU Xiang, LS
   Dearman, J
   Abram, SR
   Carter, C
   Hester, RL
AF Xiang, Lusha
   Dearman, Jennifer
   Abram, Sean R.
   Carter, Cory
   Hester, Robert L.
TI Insulin resistance and impaired functional vasodilation in obese Zucker
   rats
SO AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
LA English
DT Article
DE arachidonic acid; prostacyclin; thromboxane; diabetes
ID ENDOTHELIUM-DEPENDENT VASODILATION; SKELETAL-MUSCLE PERFUSION;
   ACTIVATED-RECEPTOR-GAMMA; BLOOD-PRESSURE; OXIDATIVE STRESS; MEDIATED
   VASOCONSTRICTION; METABOLIC SYNDROME; CARDIOVASCULAR-DISEASE;
   PROSTACYCLIN SYNTHASE; ACUTE HYPERGLYCEMIA
AB Individuals with metabolic syndrome exhibit insulin resistance and an attenuated functional vasodilatory response to exercise. We have shown that impaired functional vasodilation in obese Zucker rats (OZRs) is associated with enhanced thromboxane receptor (TP)-mediated vasoconstriction. We hypothesized that insulin resistance, hyperglycemia/hyperlipidemia, and the resultant ROS are responsible for the increased TP-mediated vasoconstriction in OZRs, resulting in impaired functional vasodilation. Eleven-week-old male lean Zucker rats (LZRs) and OZRs were fed normal rat chow or chow containing rosiglitazone (5 mg.kg(-1).day(-1)) for 2 wk. In another set of experiment, LZRs and OZRs were treated with 2 mM tempol (drinking water) for 7-10 days. After the treatments, spinotrapezius muscles were prepared, and arcade arteriolar diameters were measured following muscle stimulation and arachidonic acid (AA) application (10 mu M) in the absence and presence of the TP antagonist SQ-29548 (1 mu M). OZRs exhibited higher insulin, glucose, triglyceride, and superoxide levels and increased NADPH oxidase activity compared with LZRs. Functional and AA-induced vasodilations were impaired in OZRs. Rosiglitazone treatment improved insulin, glucose, triglyceride, and superoxide levels as well as NADHP oxidase activity in OZRs. Both rosiglitazone and tempol treatment improved vasodilatory responses in OZRs with no effect in LZRs. SQ-29548 treatment improved vasodilatory responses in nontreated OZRs with no effect in LZRs or treated OZRs. These results suggest that insulin resistance and the resultant increased ROS impair functional dilation in OZRs by increasing TP-mediated vasoconstriction.
C1 [Xiang, Lusha; Dearman, Jennifer; Abram, Sean R.; Carter, Cory; Hester, Robert L.] Univ Mississippi, Med Ctr, Dept Physiol & Biophys, Jackson, MS 39216 USA.
C3 University of Mississippi; University of Mississippi Medical Center
RP Hester, RL (corresponding author), Univ Mississippi, Med Ctr, Dept Physiol & Biophys, 2500 N State St, Jackson, MS 39216 USA.
EM rhester@physiology.umsmed.edu
RI Xiang, Lusha/JXY-0496-2024; Hester, Robert/HNS-3185-2023
OI Hester, Robert/0000-0003-0227-557X
FU NHLBI NIH HHS [HL-51971, R01 HL089581] Funding Source: Medline; PHS HHS
   [NL-63958] Funding Source: Medline
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NR 60
TC 70
Z9 77
U1 0
U2 5
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0363-6135
J9 AM J PHYSIOL-HEART C
JI Am. J. Physiol.-Heart Circul. Physiol.
PD APR
PY 2008
VL 294
IS 4
BP H1658
EP H1666
DI 10.1152/ajpheart.01206.2007
PG 9
WC Cardiac & Cardiovascular Systems; Physiology; Peripheral Vascular
   Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Physiology
GA 282NR
UT WOS:000254575000020
PM 18296567
DA 2025-06-11
ER

PT J
AU Wagenaar, CA
   Walrabenstein, W
   de Jonge, CS
   Bisschops, M
   van der Leeden, M
   van der Esch, M
   Weijs, PJM
   Troelstra, MA
   Korteweg, MA
   Nederveen, AJ
   van Schaardenburg, D
AF Wagenaar, C. A.
   Walrabenstein, W.
   de Jonge, C. S.
   Bisschops, M.
   van der Leeden, M.
   van der Esch, M.
   Weijs, P. J. M.
   Troelstra, M. A.
   Korteweg, M. A.
   Nederveen, A. J.
   van Schaardenburg, D.
TI Effect of a multidisciplinary lifestyle intervention on body composition
   in people with osteoarthritis: Secondary analysis of the "Plants for
   Joints" randomized controlled trial
SO OSTEOARTHRITIS AND CARTILAGE OPEN
LA English
DT Article
DE Osteoarthritis; Diet; Lifestyle intervention; Metabolic syndrome; Body
   composition; Magnetic resonance imaging
ID FATTY-ACID-COMPOSITION; BONE-MINERAL DENSITY; ADIPOSE-TISSUE; KNEE; HIP;
   RECOMMENDATIONS; CLASSIFICATION; ASSOCIATION; MANAGEMENT; POSITION
AB Objective: The Plants for Joints (PFJ) intervention significantly improved pain, stiffness, and physical function, and metabolic outcomes, in people with metabolic syndrome-associated osteoarthritis (MSOA). This secondary analysis investigated its effects on body composition. Method: In the randomized PFJ study, people with MSOA followed a 16-week intervention based on a whole-food plant-based diet, physical activity, and stress management, or usual care. For this secondary analysis, fat mass, muscle mass, and bone mineral density were measured using dual-energy X-ray absorptiometry (DEXA) for all participants. Additionally, in a subgroup (n = 32), hepatocellular lipid (HCL) content and composition of visceral adipose tissue (VAT) were measured using magnetic resonance spectroscopy (MRS). An intention-to-treat analysis with a linear-mixed model adjusted for baseline values was used to analyse between-group differences. Results: Of 66 people randomized, 64 (97%) completed the study. The PFJ group experienced significant weight loss (-5.2 kg; 95% CI -6.9, -3.6) compared to controls, primarily from fat mass reduction (-3.9 kg; 95% CI -5.3 to -2.5). No significant differences were found in lean mass, muscle strength, or bone mineral density between groups. In the subgroup who underwent MRI scans, the PFJ group had a greater reduction in HCL (-6.5%; 95% CI -9.9, 3.0) compared to controls, with no observed differences in VAT composition. Conclusion: The PFJ multidisciplinary intervention positively impacted clinical and metabolic outcomes, and appears to significantly reduce body fat, including liver fat, while preserving muscle mass and strength.
C1 [Wagenaar, C. A.; Walrabenstein, W.; Bisschops, M.; van der Leeden, M.; van der Esch, M.; Korteweg, M. A.; van Schaardenburg, D.] Reade Ctr Rheumatol & Rehabil, Amsterdam, Netherlands.
   [Wagenaar, C. A.; Walrabenstein, W.; van Schaardenburg, D.] Univ Amsterdam, Amsterdam UMC Locat, Dept Clin Immunol & Rheumatol, Meibergdreef 9, Amsterdam, Netherlands.
   [Wagenaar, C. A.; Walrabenstein, W.; van Schaardenburg, D.] Amsterdam Rheumatol & Immunol Ctr, Amsterdam, Netherlands.
   [de Jonge, C. S.; Troelstra, M. A.; Nederveen, A. J.] Univ Amsterdam, Dept Radiol & Nucl Med, Amsterdam UMC Locat, Meibergdreef 9, Amsterdam, Netherlands.
   [de Jonge, C. S.; Nederveen, A. J.] Amsterdam Gastroenterol Endocrinol Metab Res Inst, Amsterdam, Netherlands.
   [van der Leeden, M.] Vrije Univ Amsterdam, Dept Rehabil Med, Amsterdam UMC Locat, Boelelaan 1117, Amsterdam, Netherlands.
   [van der Leeden, M.; Nederveen, A. J.] Amsterdam Movement Sci Res Inst, Amsterdam, Netherlands.
   [van der Esch, M.] Amsterdam Univ Appl Sci, Fac Hlth, Ctr Expertise Urban Vital, Amsterdam, Netherlands.
   [Weijs, P. J. M.] Amsterdam Univ Appl Sci, Ctr Expt Urban Vital, Fac Hlth, Amsterdam, Netherlands.
   [Weijs, P. J. M.] Vrije Univ Amsterdam, Dept Nutr & Dietet, Amsterdam UMC Locat, Boelelaan 1117, Amsterdam, Netherlands.
C3 University of Amsterdam; Vrije Universiteit Amsterdam; University of
   Amsterdam; Vrije Universiteit Amsterdam; Vrije Universiteit Amsterdam
RP Wagenaar, CA (corresponding author), Admiraal Helfrichstr 1, NL-1056AA Amsterdam, Netherlands.
EM c.a.wagenaar@amsterdamumc.nl; w.walrabenstein@reade.nl;
   c.s.dejonge@amsterdamumc.nl; m.bisschops@reade.nl; m.vd.leeden@reade.nl;
   m.vd.esch@reade.nl; p.j.m.weijs@hva.nl; mtroelstra@hotmail.com;
   m.korteweg@reade.nl; a.j.nederveen@amsterdamumc.nl;
   schaardenburg@reade.nl
RI de Jonge, Catharina/AEM-1923-2022
FX Nelleke Doornebal and Marieke Rinkema. We thank the 3T MRI group from
   the Amsterdam UMC, for technical support.
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NR 42
TC 0
Z9 0
U1 0
U2 1
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
EI 2665-9131
J9 OSTEOARTHR CARTIL OP
JI Osteoarthr. Cartil. Open
PD DEC
PY 2024
VL 6
IS 4
AR 100524
DI 10.1016/j.ocarto.2024.100524
EA OCT 2024
PG 8
WC Orthopedics; Rheumatology
WE Emerging Sources Citation Index (ESCI)
SC Orthopedics; Rheumatology
GA J0E2V
UT WOS:001333885700001
PM 39435357
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Tain, YL
   Wu, KLH
   Lee, WC
   Leu, S
   Chan, JYH
AF Tain, You-Lin
   Wu, Kay L. H.
   Lee, Wei-Chia
   Leu, Steve
   Chan, Julie Y. H.
TI Maternal fructose-intake-induced renal programming in adult male
   offspring
SO JOURNAL OF NUTRITIONAL BIOCHEMISTRY
LA English
DT Article
DE Arachidonic acid; Developmental programming; Endothelium-derived
   hyperpolarizing factor; Fructose; Hypertension; Next-generation
   sequencing
ID ARACHIDONIC-ACID METABOLITES; BLOOD-PRESSURE; NITRIC-OXIDE; OXIDATIVE
   STRESS; KIDNEY-DISEASE; HYPERTENSION; RATS; SUPPLEMENTATION;
   RESTRICTION; EPIGENETICS
AB Nutrition in pregnancy can elicit long-term effects on the health of offspring. Although fructose consumption has increased globally and is linked to metabolic syndrome, little is known about the long-term effects of maternal high-fructose (HF) exposure during gestation and lactation, especially on renal programming. We examined potential key genes and pathways that are associated with HF-induced renal programming using whole-genome RNA next-generation sequencing (NGS) to quantify the abundance of RNA transcripts in kidneys from 1-day-, 3-week-, and 3-month-old male offspring. Pregnant Sprague-Dawley rats received regular chow or chow supplemented with HF (60% diet by weight) during the entire period of pregnancy and lactation. Male offspring exhibited programmed hypertension at 3 months of age. Maternal HF intake modified over 200 renal transcripts from nephrogenesis stage to adulthood. We observed that 20 differentially expressed genes identified in 1-day-old kidney are related to regulation of blood pressure. Among them, Hmox1, Bdkrb2, Adra2b, Ptgs2, Col1a2 and Tbxa2r are associated with endothelium-derived hyperpolarizing factor (EDHF). NGS also identified genes in arachidonic acid metabolism (Cyp2c23, Hpgds, Ptgds and Ptges) that may be potential key genes/pathways contributing to renal programming and hypertension. Collectively, our NGS data suggest that maternal HF intake elicits a defective adaptation of interrelated EDHFs during nephrogenesis which may lead to renal programming and hypertension in later life. Moreover, our results highlight genes and pathways involved in renal programming as potential targets for therapeutic approaches to prevent metabolic-syndrome-related comorbidities in children with HF exposure in early life. (C) 2015 Elsevier Inc. All rights reserved.
C1 [Tain, You-Lin] Kaohsiung Chang Gung Mem Hosp, Dept Pediat, Kaohsiung 83301, Taiwan.
   [Tain, You-Lin; Wu, Kay L. H.; Lee, Wei-Chia; Leu, Steve; Chan, Julie Y. H.] Chang Gang Univ, Coll Med, Kaohsiung, Taiwan.
   [Tain, You-Lin; Wu, Kay L. H.; Leu, Steve; Chan, Julie Y. H.] Kaohsiung Chang Gung Mem Hosp, Ctr Translat Res Biomed Sci, Kaohsiung 83301, Taiwan.
   [Lee, Wei-Chia] Kaohsiung Chang Gung Mem Hosp, Dept Urol, Kaohsiung 83301, Taiwan.
C3 Chang Gung Memorial Hospital; Chang Gung University; Chang Gung Memorial
   Hospital; Chang Gung Memorial Hospital
RP Chan, JYH (corresponding author), Kaohsiung Chang Gung Mem Hosp, Ctr Translat Res Biomed Sci, Kaohsiung 83301, Taiwan.
EM jchan@adm.cgmh.org.tw
RI Tain, You-Lin/H-2827-2019; Leu, Steve/D-6807-2011; Chan,
   Julie/X-5253-2019; Wu, Kay/ACD-1767-2022
OI Tain, You-Lin/0000-0002-7059-6407; Lee, Wei-Chia/0000-0003-0701-2285;
   Wu, Kay L.H./0000-0002-7297-6788
FU Chang Gung Memorial Hospital, Kaohsiung, Taiwan [CMRPG8C0042]; National
   Science Council, Taiwan [NSC 101-2314-B-182A-021-MY3]
FX This work was supported by Grant CMRPG8C0042 from Chang Gung Memorial
   Hospital, Kaohsiung, Taiwan, and the Grant NSC 101-2314-B-182A-021-MY3
   from National Science Council, Taiwan. We also thank Dr. Sung-Chou Li
   and the Genomic & Proteomic Core Laboratory, Department of Medical
   Research, Kaohsiung Chang Gung Memorial Hospital, for help with analysis
   of RNA-Seq data.
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NR 34
TC 58
Z9 60
U1 0
U2 8
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0955-2863
EI 1873-4847
J9 J NUTR BIOCHEM
JI J. Nutr. Biochem.
PD JUN
PY 2015
VL 26
IS 6
BP 642
EP 650
DI 10.1016/j.jnutbio.2014.12.017
PG 9
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA CI6ZM
UT WOS:000354912700008
PM 25765514
DA 2025-06-11
ER

PT J
AU Mallidis, C
   Czerwiec, A
   Filippi, S
   O'Neill, J
   Maggi, M
   McClure, N
AF Mallidis, Con
   Czerwiec, Agnieszka
   Filippi, Sandra
   O'Neill, Jason
   Maggi, Mario
   McClure, Neil
TI Spermatogenic and sperm quality differences in an experimental model of
   metabolic syndrome and hypogonadal hypogonadism
SO REPRODUCTION
LA English
DT Article
ID BODY-MASS INDEX; GLYCATION END-PRODUCTS; REPRODUCTIVE HORMONES;
   FUNCTIONAL-ACTIVITY; OXIDATIVE STRESS; SEMEN QUALITY; MALE OBESITY;
   OVERWEIGHT; RECEPTOR; IMPACT
AB The synergistic effect of the co-morbidities that comprise metabolic syndrome (MetS) is increasingly being recognised as an important contributor in the pathology of a broad spectrum of seemingly disparate conditions. However, in terms of male reproductive function, beyond erectile dysfunction, little is known about the influence of this cohort (collectively or separately) on spermatogenesis and sperm quality. The aims of this study were to assess the reproductive tract of a MetS animal model for detrimental changes, to determine whether a group of compounds (advanced glycation end products and their receptor) known to cause cell dysfunction and DNA damage was present and assess whether hypogonadotropic hypogonadism was the main contributing factor for the changes seen. Animals fed a high-fat diet were found to have significantly increased cholesterol, triglycerides, blood glucose, mean arterial pressure and visceral fat levels. Although serum testosterone was decreased, no changes were seen in either testicular or epididymal histology. Immunolocalisation of N-epsilon-carboxymethyl-lysine and the receptor for advanced glycation end products was found in the testes, epididymides and sperm of the two treated groups of animals; however, ELISA did not show any difference in protein levels. Similarly, assessment of sperm nuclear DNA (nDNA) fragmentation by acridine orange test did not find significant differences in nDNA integrity. We conclude that the minimal effect on spermatogenesis and sperm quality seen in our model is probably due to the moderate increase of blood glucose rather than the hypogonadism. Reproduction (2011) 142 63-71
C1 [Mallidis, Con] Univ Munster, Ctr Reprod Med & Androl, D-48149 Munster, Germany.
   [Mallidis, Con; Czerwiec, Agnieszka; O'Neill, Jason; McClure, Neil] Queens Univ Belfast, Dept Obstet & Gynaecol, Belfast BT12 6BJ, Antrim, North Ireland.
   [Filippi, Sandra; Maggi, Mario] Univ Florence, Dept Clin Physiopathol, Androl & Sexual Med Unit, I-50139 Florence, Italy.
C3 University of Munster; Queens University Belfast; University of Florence
RP Mallidis, C (corresponding author), Univ Munster, Ctr Reprod Med & Androl, Domagkstr 11, D-48149 Munster, Germany.
EM con.mallidis@ukmuenster.de
RI Maggi, Mario/AAB-8284-2019
OI MAGGI, Mario/0000-0003-3267-4221; Mallidis, Con/0000-0001-9531-3808
FU Fertility Research Trust
FX The authors thank our colleagues in the Centre for Vision Science,
   Queen's University of Belfast, for their advice and assistance. We
   gratefully acknowledge the financial support of the Fertility Research
   Trust.
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NR 54
TC 30
Z9 31
U1 1
U2 10
PU BIOSCIENTIFICA LTD
PI BRISTOL
PA EURO HOUSE, 22 APEX COURT WOODLANDS, BRADLEY STOKE, BRISTOL BS32 4JT,
   ENGLAND
SN 1470-1626
J9 REPRODUCTION
JI Reproduction
PD JUL
PY 2011
VL 142
IS 1
BP 63
EP 71
DI 10.1530/REP-10-0472
PG 9
WC Developmental Biology; Reproductive Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Developmental Biology; Reproductive Biology
GA 792HC
UT WOS:000292731400006
PM 21464116
OA Bronze
DA 2025-06-11
ER

PT J
AU Lever, M
   Slow, S
AF Lever, Michael
   Slow, Sandy
TI The clinical significance of betaine, an osmolyte with a key role in
   methyl group metabolism
SO CLINICAL BIOCHEMISTRY
LA English
DT Article
DE Betaine; Osmoregulation; Methyl group metabolism; Pregnancy; Metabolic
   syndrome; Diabetes; Vascular disease; Homocysteine
ID HOMOCYSTEINE-S-METHYLTRANSFERASE; ENDOPLASMIC-RETICULUM STRESS;
   NUCLEAR-MAGNETIC-RESONANCE; ONE-CARBON METABOLISM; TOTAL PLASMA
   HOMOCYSTEINE; NEURAL-TUBE DEFECTS; GLYCINE BETAINE; RAT-LIVER; DNA
   METHYLATION; METHIONINE METABOLISM
AB Betaine is an essential osmolyte and source of methyl groups and comes from either the diet or by the oxidation of choline. Its metabolism methylates homocysteine to methionine, also producing N,N-dimethylglycine. Betaine insufficiency is associated with the metabolic syndrome, lipid disorders and diabetes, and may have a role in vascular and other diseases. Betaine is important in development, from the pre-implantation embryo to infancy. Betaine supplementation improves animal and poultry health, but the effect of long-term supplementation on humans is not known, though reports that it improves athletic performance will stimulate further studies. Subsets of the population that may benefit from betaine supplementation could be identified by the laboratory, in particular those who excessively lose betaine through the urine. Plasma betaine is highly individual, in women typically 20-60 mu mol/L and in men 25-75 mu mol/L.
   Plasma dimethylglycine is typically <10 mu mol/L. Urine betaine excretion is minimal, even following a large betaine dose. It is constant, highly individual and normally <35 mmol/mole creatinine. The preferred method of betaine measurement is by LC-MS/MS, which is rapid and capable of automation. Slower HPLC methods give comparable results. Proton NMR spectrometry is another option but caution is needed to avoid confusion with trimethylamine-N-oxide. (C) 2010 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
C1 [Lever, Michael; Slow, Sandy] Canterbury Hlth Labs, Biochem Unit, Christchurch 8140, New Zealand.
C3 Canterbury Health Laboratories
RP Lever, M (corresponding author), Canterbury Hlth Labs, Biochem Unit, POB 151, Christchurch 8140, New Zealand.
EM michael.lever@otago.ac.nz
FU Heart Foundation of New Zealand; Neurological Foundation of New Zealand;
   Paykel Trust
FX We are grateful for support from the Heart Foundation of New Zealand,
   the Neurological Foundation of New Zealand and the Paykel Trust. Comment
   from Professor Per Ueland has been especially appreciated. Other
   valuable suggestions have been made by Dr. Stuart Craig and by
   Professors Steve Chambers and Peter George.
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NR 231
TC 368
Z9 409
U1 1
U2 82
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0009-9120
EI 1873-2933
J9 CLIN BIOCHEM
JI Clin. Biochem.
PD JUN
PY 2010
VL 43
IS 9
BP 732
EP 744
DI 10.1016/j.clinbiochem.2010.03.009
PG 13
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA 602TH
UT WOS:000278161200006
PM 20346934
DA 2025-06-11
ER

PT J
AU Schalkwijk, CG
   Stehouwer, CDA
AF Schalkwijk, CG
   Stehouwer, CDA
TI Vascular complications in diabetes mellitus: the role of endothelial
   dysfunction
SO CLINICAL SCIENCE
LA English
DT Review
DE diabetes mellitus; endothelial dysfunction; hyperglycaemia; insulin
   resistance; metabolic syndrome; oxidative stress; vascular complication
ID C-REACTIVE PROTEIN; NITRIC-OXIDE SYNTHASE; CELL-ADHESION MOLECULE-1;
   VON-WILLEBRAND-FACTOR; GROWTH-FACTOR-BETA; ADVANCED GLYCATION
   ENDPRODUCTS; URINARY ALBUMIN EXCRETION; ADIPOSE-SPECIFIC PROTEIN;
   CORONARY-HEART-DISEASE; FACTOR MESSENGER-RNA
AB The endothelium is a complex organ with a multitude of properties essential for control of vascular functions. Dysfunction of the vascular endothelium is regarded as an important factor in the pathogenesis of diabetic micro- and macro-angiopathy. Endothelial dysfunction in Type I and 11 diabetes complicated by micro- or macro-albuminuria is generalized in that it affects many aspects of endothelial function and occurs not only in the kidney. The close linkage between micro-albuminuria and endothelial dysfunction in diabetes is an attractive explanation, for the fact that microalbuminuria is a risk marker for atherothrombosis. In Type I diabetes, endothelial dysfunction precedes and may cause diabetic microangiopathy, but it is not clear whether endothelial dysfunction is a feature of the diabetic state itself. In Type 11 diabetes, endothelial function is impaired from the onset of the disease and is strongly related to adverse outcomes. It is not clear whether impaired endothelial function is caused by hyperglycaemia or by other factors. Impaired endothelial function is closely associated with and may contribute to insulin resistance regardless of the presence of diabetes. Endothelial dysfunction in diabetes originates from three main sources. Hyperglycaemia and its immediate biochemical sequelae directly alter endothelial function or influence endothelial cell functioning indirectly by the synthesis of growth factors, cytokines and vasoactive agents in other cells. Finally, the components of the metabolic syndrome can impair endothelial function.
C1 Maastricht Univ, Dept Internal Med, NL-6202 AZ Maastricht, Netherlands.
   Univ Maastricht, Cardiovasc Res Inst, NL-6200 MD Maastricht, Netherlands.
C3 Maastricht University; Maastricht University
RP Maastricht Univ, Dept Internal Med, Debeyelaan 25, NL-6202 AZ Maastricht, Netherlands.
EM C.Schalkwijk@intmed.unimaas.nl
RI Stehouwer, Coen/AAB-3435-2021
OI Stehouwer, Coen/0000-0001-8752-3223; Schalkwijk, Casper
   G/0000-0003-0190-2690
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NR 190
TC 500
Z9 581
U1 1
U2 45
PU PORTLAND PRESS LTD
PI LONDON
PA 1ST FLR, 10 QUEEN STREET PLACE, LONDON, ENGLAND
SN 0143-5221
EI 1470-8736
J9 CLIN SCI
JI Clin. Sci.
PD AUG
PY 2005
VL 109
IS 2
BP 143
EP 159
DI 10.1042/CS20050025
PG 17
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 954FC
UT WOS:000231138500003
PM 16033329
DA 2025-06-11
ER

PT J
AU Kumar, AA
   Huangfu, GV
   Figtree, GA
   Dwivedi, G
AF Kumar, Annora Ai-Wei
   Huangfu, Gavin
   Figtree, Gemma A.
   Dwivedi, Girish
TI Atherosclerosis as the Damocles' sword of human evolution: insights from
   nonhuman ape-like primates, ancient human remains, and isolated modern
   human populations
SO AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
LA English
DT Review
DE atherosclerosis; cardiovascular disease; evolution; immune system;
   inflammation
ID CORONARY-ARTERY-DISEASE; CLONAL HEMATOPOIESIS; RISK-FACTORS; METABOLIC
   SYNDROME; GUT MICROBIOME; GENE; INFLAMMATION; PREVALENCE; IMMUNITY;
   DYSFUNCTION
AB Atherosclerosis is the leading cause of death worldwide, and the predominant risk factors are advanced age and high-circulating low-density lipoprotein cholesterol (LDL-C). However, the findings of atherosclerosis in relatively young mummified remains and a lack of atherosclerosis in chimpanzees despite high LDL-C call into question the role of traditional cardiovascular risk factors. The inflammatory theory of atherosclerosis may explain the discrepancies between traditional risk factors and observed phenomena in current literature. Following the divergence from chimpanzees several millennia ago, loss of function mutations in immune regulatory genes and changes in gene expression have resulted in an overactive human immune system. The ubiquity of atherosclerosis in the modern era may reflect a selective pressure that enhanced the innate immune response at the cost of atherogenesis and other chronic disease states. Evidence provided from the fields of genetics, evolutionary biology, and paleoanthropology demonstrates a sort of circular dependency between inflammation, immune system functioning, and evolution at both a species and cellular level. More recently, the role of proinflammatory stimuli, somatic mutations, and the gene-environment effect appear to be underappreciated elements in the development and progression of atherosclerosis. Neurobiological stress, metabolic syndrome, and traditional cardiovascular risk factors may instead function as intermediary links between inflammation and atherosclerosis. Therefore, considering evolution as a mechanistic process and atherosclerosis as part of the inertia of evolution, greater insight into future preventative and therapeutic interventions for atherosclerosis can be gained by examining the past.
C1 [Kumar, Annora Ai-Wei; Huangfu, Gavin; Dwivedi, Girish] Univ Western Australia, Med Sch, Crawley, WA, Australia.
   [Huangfu, Gavin; Dwivedi, Girish] Fiona Stanley Hosp, Dept Cardiol, Murdoch, WA, Australia.
   [Huangfu, Gavin; Dwivedi, Girish] Harry Perkins Inst Med Res, Murdoch, WA, Australia.
   [Figtree, Gemma A.] Kolling Inst Med Res, Cardiovasc Discovery Grp, St Leonards, NSW, Australia.
   [Figtree, Gemma A.] Royal North Shore Hosp, Dept Cardiol, St Leonards, NSW, Australia.
C3 University of Western Australia; South Metropolitan Health Service;
   Fiona Stanley Fremantle Hospitals Group; Fiona Stanley Hospital; Harry
   Perkins Institute of Medical Research; University of Sydney; Kolling
   Institute of Medical Research; Royal North Shore Hospital
RP Dwivedi, G (corresponding author), Univ Western Australia, Med Sch, Crawley, WA, Australia.; Dwivedi, G (corresponding author), Fiona Stanley Hosp, Dept Cardiol, Murdoch, WA, Australia.; Dwivedi, G (corresponding author), Harry Perkins Inst Med Res, Murdoch, WA, Australia.; Figtree, GA (corresponding author), Kolling Inst Med Res, Cardiovasc Discovery Grp, St Leonards, NSW, Australia.; Figtree, GA (corresponding author), Royal North Shore Hosp, Dept Cardiol, St Leonards, NSW, Australia.
EM gemma.figtree@sydney.edu.au; girish.dwivedi@perkins.uwa.edu.au
RI Figtree, Gemma/AGS-7561-2022
OI Kumar, Annora/0000-0003-4895-3954; Dwivedi, Girish/0000-0003-0717-740X;
   Huangfu, Gavin/0000-0002-2244-6033
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NR 125
TC 1
Z9 1
U1 2
U2 6
PU AMER PHYSIOLOGICAL SOC
PI Rockville
PA 6120 Executive Blvd, Suite 600, Rockville, MD, UNITED STATES
SN 0363-6135
EI 1522-1539
J9 AM J PHYSIOL-HEART C
JI Am. J. Physiol.-Heart Circul. Physiol.
PD MAR 2
PY 2024
VL 326
IS 3
BP H821
EP H831
DI 10.1152/ajpheart.00744.2023
PG 11
WC Cardiac & Cardiovascular Systems; Physiology; Peripheral Vascular
   Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Physiology
GA KN0I7
UT WOS:001180523300004
PM 38305751
DA 2025-06-11
ER

PT J
AU Wang, B
   Zhang, YQ
   Gai, L
   He, YJ
   Qiu, H
   Li, P
AF Wang, Bing
   Zhang, Yiqing
   Gai, Lin
   He, Yujie
   Qiu, Hong
   Li, Ping
TI Identification of key biomarkers in hepatocellular carcinoma induced by
   non-alcoholic Steatohepatitis or metabolic syndrome via integrated
   bioinformatics analysis
SO CELLULAR AND MOLECULAR BIOLOGY
LA English
DT Article
DE Tumor biomarkers; hepatocellular carcinoma; gene expression profiling;
   metabolic syndrome; Non-alcoholic fatty liver disease
ID GENE-EXPRESSION; HEPATITIS-B; CANCER; MUTATIONS
AB The burden of hepatocellular carcinoma (HCC) is steadily growing because obesity, type 2 diabetes, and nonalcoholic fatty liver disease (NAFLD) are replacing viral- and alcohol-related liver disease as major pathogenic promoters. The current study attempted to identify the key genes and pathways in the non-alcoholic steatohepatitis (NASH) induced development of HCC using integrated bioinformatics analyses. Two gene expression profiling datasets, GSE102079 and GSE164760 were downloaded. Differentially expressed genes (DEGs) from HCC and healthy control samples were screened. Functional enrichment analyses based on Gene Ontology (GO) resource, Kyoto Encyclopedia of Genes and Genomes (KEGG) resource. Then protein-protein interaction (PPI) of these DEGs was visualized by Cytoscape with Search Tool for the Retrieval of Interacting Genes (STRING). Expression and survival analysis of hub genes, methylation and genetic mutation analysis were explored with GEPIA2, UALCAN, GSCA, and TIMER2.0 databases. We identified 158 overlapping genes from the 2 datasets. Up-regulated genes were mainly related to the proliferation, adhesion and metastasis of tumors, while down-regulated genes were mainly related to oxidative stress and energy metabolism. CDKN2A, SPP1, CYP2C9 and CYP4A11 were associated with prognostic performance and were considered the potential crucial genes, which SPP1, CYP2C9 and CYP4A11 were identified as the DNA methylation-driven genes. In different mutation statuses of HCC, gene expression of CDKN2A, SPP1, CYP2C9 and CYP4A11 showed significant differences. CDKN2A and SPP1 were identified as risk genes, while CYP2C9 and CYP4A11 were identified as protective genes, which may affect the transformation of NASH into HCC.
C1 [Wang, Bing; Zhang, Yiqing; Gai, Lin; He, Yujie; Qiu, Hong; Li, Ping] Jinling Hosp, Qinhuai Med Dist, Nanjing 210002, Jiangsu, Peoples R China.
RP Qiu, H (corresponding author), Jinling Hosp, Qinhuai Med Dist, Nanjing 210002, Jiangsu, Peoples R China.
EM mapleqh@126.com
RI He, Yujie/AFS-5356-2022
FU Jinling Hospital Natural Science Foundation [YYMS2021039]
FX Acknowledgements This work was supported by Jinling Hospital Natural
   Science Foundation (YYMS2021039) .
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NR 50
TC 2
Z9 2
U1 1
U2 4
PU C M B  ASSOC
PI POITIERS
PA 34 BOULEVARD SOLFERINO, 86000 POITIERS, FRANCE
SN 0145-5680
EI 1165-158X
J9 CELL MOL BIOL
JI Cell. Mol. Biol.
PY 2023
VL 69
IS 7
BP 174
EP 180
DI 10.14715/cmb/2023.69.7.28
PG 7
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA U2WO6
UT WOS:001083458600028
PM 37715392
OA hybrid
DA 2025-06-11
ER

PT J
AU Blaha, I
   Recio, P
   Martínez, MP
   López-Oliva, ME
   Ribeiro, ASF
   Agis-Torres, A
   Martínez, AC
   Benedito, S
   García-Sacristán, A
   Fernandes, VS
   Hernández, M
AF Blaha, Igor
   Recio, Paz
   Pilar Martinez, Maria
   Elvira Lopez-Oliva, Maria
   Ribeiro, Ana S. F.
   Agis-Torres, Angel
   Cristina Martinez, Ana
   Benedito, Sara
   Garcia-Sacristan, Albino
   Fernandes, Vitor S.
   Hernandez, Medardo
TI Impaired Excitatory Neurotransmission in the Urinary Bladder from the
   Obese Zucker Rat: Role of Cannabinoid Receptors
SO PLOS ONE
LA English
DT Article
ID METABOLIC SYNDROME; OXIDATIVE STRESS; TRACT SYMPTOMS; DIABETIC-RATS;
   DYSFUNCTION; OVERACTIVITY; NERVE; MOUSE; EXPRESSION; AGONISTS
AB Metabolic syndrome (MS) is a known risk factor for lower urinary tract symptoms. This study investigates whether functional and expression changes of cannabinoid CB1 and CB2 receptors are involved in the bladder dysfunction in an obese rat model with insulin resistance. Bladder samples from obese Zucker rat (OZR) and their respective controls lean Zucker rat (LZR) were processed for immunohistochemistry and western blot for studying the cannabinoid receptors expression. Detrusor smooth muscle (DSM) strips from LZR and OZR were also mounted in myographs for isometric force recordings. Neuronal and smooth muscle CB1 and CB2 receptor expression and the nerve fiber density was diminished in the OZR bladder. Electrical field stimulation (EFS) and acetylcholine (ACh) induced frequency-and concentration-dependent contractions of LZR and OZR DSM. ACh contractile responses were similar in LZR and OZR. EFS-elicited contractions, however, were reduced in OZR bladder. Cannabinoid receptor agonists and antagonists failed to modify the DSM basal tension in LZR and OZR In LZR bladder, EFS responses were inhibited by ACEA and SER-601, CB1 and CB2 receptor agonists, respectively, these effects being reversed by ACEA plus the CB1 antagonist, AM-251 or SER-601 plus the CB2 antagonist, AM-630. In OZR bladder, the inhibitory action of ACEA on nerve-evoked contractions was diminished, whereas that SER-601 did not change EFS responses. These results suggest that a diminished function and expression of neuronal cannabinoid CB1 and CB2 receptors, as well as a lower nerve fiber density is involved in the impaired excitatory neurotransmission of the urinary bladder from the OZR.
C1 [Blaha, Igor] Hosp Gen Univ Gregorio Maranon, Dept Urol, Madrid 28007, Spain.
   [Recio, Paz; Elvira Lopez-Oliva, Maria; Ribeiro, Ana S. F.; Agis-Torres, Angel; Cristina Martinez, Ana; Benedito, Sara; Garcia-Sacristan, Albino; Fernandes, Vitor S.; Hernandez, Medardo] Univ Complutense Madrid, Fac Farm, Dept Fisiol, E-28040 Madrid, Spain.
   [Pilar Martinez, Maria] Univ Complutense Madrid, Fac Vet, Dept Anat & Anat Patol Comparadas, E-28040 Madrid, Spain.
C3 General University Gregorio Maranon Hospital; Complutense University of
   Madrid; Complutense University of Madrid
RP Hernández, M (corresponding author), Univ Complutense Madrid, Fac Farm, Dept Fisiol, E-28040 Madrid, Spain.
EM medardo@ucm.es
RI López-Oliva, Elvira/L-1660-2014; Fernandes, Vitor Samuel/F-3437-2013;
   Martinez, Ana Cristina/H-9795-2015; Fernandes Ribeiro, Ana
   Sofia/F-3428-2013; BENEDITO, SARA/H-9730-2015; Martinez,
   Pilar/E-8591-2016
OI Fernandes, Vitor Samuel/0000-0001-6060-9035; Martinez, Ana
   Cristina/0000-0002-2829-0914; Fernandes Ribeiro, Ana
   Sofia/0000-0003-3913-7859; AGIS TORRES, ANGEL/0000-0002-3548-7264;
   BENEDITO, SARA/0000-0001-9660-2409; Martinez, Pilar/0000-0001-9063-3191
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NR 34
TC 3
Z9 3
U1 1
U2 5
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JUN 10
PY 2016
VL 11
IS 6
AR e0157424
DI 10.1371/journal.pone.0157424
PG 13
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA DO1UG
UT WOS:000377564000066
PM 27285468
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Agrawal, R
   Gomez-Pinilla, F
AF Agrawal, Rahul
   Gomez-Pinilla, Fernando
TI Metabolic syndrome' in the brain: deficiency in omega-3 fatty acid
   exacerbates dysfunctions in insulin receptor signalling and cognition
SO JOURNAL OF PHYSIOLOGY-LONDON
LA English
DT Article
ID SYNAPTIC VESICLE MEMBRANE; DOCOSAHEXAENOIC ACID; NEUROMUSCULAR SYNAPSES;
   LIPID-PEROXIDATION; LEARNING-ABILITY; OXIDATIVE STRESS; RAT MODEL;
   SYNAPTOPHYSIN; PROTEIN; HOMEOSTASIS
AB We pursued studies to determine the effects of the metabolic syndrome (MetS) on brain, and the possibility of modulating these effects by dietary interventions. In addition, we have assessed potential mechanisms by which brain metabolic disorders can impact synaptic plasticity and cognition. We report that high-dietary fructose consumption leads to an increase in insulin resistance index, and insulin and triglyceride levels, which characterize MetS. Rats fed on an n-3 deficient diet showed memory deficits in a Barnes maze, which were further exacerbated by fructose intake. In turn, an n-3 deficient diet and fructose interventions disrupted insulin receptor signalling in hippocampus as evidenced by a decrease in phosphorylation of the insulin receptor and its downstream effector Akt. We found that high fructose consumption with an n-3 deficient diet disrupts membrane homeostasis as evidenced by an increase in the ratio of n-6/n-3 fatty acids and levels of 4-hydroxynonenal, a marker of lipid peroxidation. Disturbances in brain energy metabolism due to n-3 deficiency and fructose treatments were evidenced by a significant decrease in AMPK phosphorylation and its upstream modulator LKB1 as well as a decrease in Sir2 levels. The decrease in phosphorylation of CREB, synapsin I and synaptophysin levels by n-3 deficiency and fructose shows the impact of metabolic dysfunction on synaptic plasticity. All parameters of metabolic dysfunction related to the fructose treatment were ameliorated by the presence of dietary n-3 fatty acid. Results showed that dietary n-3 fatty acid deficiency elevates the vulnerability to metabolic dysfunction and impaired cognitive functions by modulating insulin receptor signalling and synaptic plasticity.
C1 [Agrawal, Rahul; Gomez-Pinilla, Fernando] Univ Calif Los Angeles, Dept Integrat Biol & Physiol, Los Angeles, CA 90095 USA.
   [Gomez-Pinilla, Fernando] Univ Calif Los Angeles, Dept Neurosurg, Brain Injury Res Ctr, Los Angeles, CA 90095 USA.
C3 University of California System; University of California Los Angeles;
   University of California System; University of California Los Angeles
RP Gomez-Pinilla, F (corresponding author), Univ Calif Los Angeles, Dept Integrat Biol & Physiol, 621 Charles E Young Dr S, Los Angeles, CA 90095 USA.
EM fgomezpi@ucla.edu
RI Agrawal, Rahul/F-6412-2015
OI Agrawal, Rahul/0000-0001-8128-3724
FU National Institutes of Health [NS50465, NS56413]
FX This work was supported by National Institutes of Health Grants NS50465
   and NS56413.
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NR 47
TC 175
Z9 200
U1 1
U2 33
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-3751
EI 1469-7793
J9 J PHYSIOL-LONDON
JI J. Physiol.-London
PD MAY
PY 2012
VL 590
IS 10
BP 2485
EP 2499
DI 10.1113/jphysiol.2012.230078
PG 15
WC Neurosciences; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Physiology
GA 942ZK
UT WOS:000304090000028
PM 22473784
OA Green Published
DA 2025-06-11
ER

PT J
AU Ben-Dov, IZ
   Kark, JD
AF Ben-Dov, Iddo Z.
   Kark, Jeremy D.
TI Serum uric acid is a GFR-independent long-term predictor of acute and
   chronic renal insufficiency: the Jerusalem Lipid Research Clinic cohort
   study
SO NEPHROLOGY DIALYSIS TRANSPLANTATION
LA English
DT Article
DE acute kidney injury; chronic kidney disease; cohort study; mortality;
   uric acid
ID CHRONIC-KIDNEY-DISEASE; BLOOD-PRESSURE; METABOLIC SYNDROME; OXIDATIVE
   STRESS; HYPERURICEMIA; PROGRESSION; RISK; ALLOPURINOL; MARKER;
   HYPOURICEMIA
AB Background. Kidney disease is commonly accompanied by hyperuricemia. However, the contribution of serum uric acid (SUA) to kidney injury is debated. Our objective was to assess the long-term prediction of renal failure by SUA.
   Methods. Visit 2 participants in the Jerusalem Lipid Research Clinic cohort with normal baseline kidney function were followed for 24-28 years. SUA levels were assessed for associations with acute renal failure (ARF) and chronic renal failure (CRF) as defined by hospital discharge records, and mortality, ascertained through linkage with the national population registry.
   Results. Among 2449 eligible participants (1470 men, 979 women aged 35-78 years in 1976-79), SUA was positively linked with male sex, serum creatinine and components of the metabolic syndrome but was lower in smokers and in diabetic subjects. The 22- to 25-year incidence of hospital-diagnosed kidney failure (145 first events, 67% CRF) and the 24- to 28-year mortality (587 events) were higher in subject with hyperuricemia (>6.5 mg/dL in men and >5.3 mg/dL in women, reflecting the upper quintiles), independent of baseline kidney function and covariates. Hyperuricemia conferred adjusted hazard ratios of 1.36 (P = 0.003), 2.14 (P < 0.001) and 2.87 (P = 0.003) for mortality, CRF and ARF, respectively.
   Conclusions. SUA predicts renal failure incidence and all-cause mortality independently of demographic and clinical covariates. These results lend support to the undertaking of clinical trials to examine the effect of uric acid-lowering strategies on kidney outcomes.
C1 [Ben-Dov, Iddo Z.] Rockefeller Univ, Lab RNA Mol Biol, New York, NY 10065 USA.
   [Kark, Jeremy D.] Hebrew Univ Jerusalem, Epidemiol Unit, Hadassah Sch Publ Hlth & Community Med, IL-91120 Jerusalem, Israel.
C3 Rockefeller University; Hebrew University of Jerusalem
RP Ben-Dov, IZ (corresponding author), Rockefeller Univ, Lab RNA Mol Biol, New York, NY 10065 USA.
EM iben@rockefeller.edu
RI Ben-Dov, Iddo/F-3282-2010
OI Ben-Dov, Iddo/0000-0002-9180-3604
FU National Center for Research Resources, National Institutes of Health
   (NIH) [UL1RR024143]; NIH Roadmap for Medical Research; American
   Physicians Fellowship for Medicine in Israel; US-Israel Binational
   Science Foundation; Israel Science Foundation; US National Heart, Lung
   and Blood Institute [NO1-HV-5-3015-L]
FX IZB is supported by Grant Award Number UL1RR024143 from the National
   Center for Research Resources, a component of the National Institutes of
   Health (NIH) and NIH Roadmap for Medical Research. IZB is also supported
   in part by a fellowship from the American Physicians Fellowship for
   Medicine in Israel. The Jerusalem LRC follow-up component was supported
   by grants to JDK from the US-Israel Binational Science Foundation and
   the Israel Science Foundation. The Jerusalem LRC Prevalence Study was
   supported by the US National Heart, Lung and Blood Institute Contract No
   NO1-HV-5-3015-L.
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NR 48
TC 65
Z9 73
U1 0
U2 2
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0931-0509
EI 1460-2385
J9 NEPHROL DIAL TRANSPL
JI Nephrol. Dial. Transplant.
PD AUG
PY 2011
VL 26
IS 8
BP 2558
EP 2566
DI 10.1093/ndt/gfq740
PG 9
WC Transplantation; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Transplantation; Urology & Nephrology
GA 800CM
UT WOS:000293336500023
PM 21220750
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Jeong, Y
   Park, S
   Kwon, E
   Hur, YM
   You, YA
   Kim, SM
   Lee, G
   Lee, KA
   Kim, SJ
   Cho, GJ
   Oh, MJ
   Na, SH
   Lee, SJ
   Bae, JG
   Kim, YH
   Lee, SJ
   Kim, YH
   Kim, YJ
AF Jeong, Yeonseong
   Park, Sunwha
   Kwon, Eunjin
   Hur, Young Min
   You, Young-Ah
   Kim, Soo Min
   Lee, Gain
   Lee, Kyung A.
   Kim, Soo Jung
   Cho, Geum Joon
   Oh, Min-Jeong
   Na, Sung Hun
   Lee, Se jin
   Bae, Jin-Gon
   Kim, Yu-Hwan
   Lee, Soo-Jeong
   Kim, Young-Han
   Kim, Young Ju
CA APPO Study Group
TI Personal exposure of PM2.5 and metabolic syndrome markers of
   pregnant women in South Korea: APPO study
SO ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
LA English
DT Article
DE Particulate matter; Indoor air pollution; Pregnancy complications;
   Metabolic dysfunction; Glucose intolerance; Lipid metabolism
ID AMBIENT AIR-POLLUTION; FINE PARTICULATE MATTER; HDL-CHOLESTEROL RATIO;
   BETA-CELL FUNCTION; OXIDATIVE STRESS; INSULIN SENSITIVITY;
   GLUCOSE-METABOLISM; DIABETES-MELLITUS; RISK; ASSOCIATIONS
AB We examined the association between exposure to PM2.5, focused on individual exposure level, and metabolic dysfunction during pregnancy. APPO study (Air Pollution on Pregnancy Outcome) was a prospective, multicenter, observational cohort study conducted from January 2021 to March 2023. Individual PM2.5 concentrations were calculated using a time-weighted average model. Metabolic dysfunction during pregnancy was assessed based on a modified definition of metabolic syndrome and its components, accounting for pregnancy-specific criteria. Exposure to PM2.5 during pregnancy was associated with worsened metabolic parameters especially glucose metabolism. In comparison to participants exposed to the low PM2.5 group, those exposed to high PM2.5 levels exhibited increased odds of gestational diabetes mellitus (GDM) after adjusting for confounding variables in different adjusted models. Specifically, in model 1, the adjusted odds ratio (aOR) was 3.117 with a 95% confidence interval (CI) of 1.234-7.870; in model 2, the aOR was 3.855 with a 95% CI of 1.255-11.844; in model 3, the aOR was 3.404 with a 95% CI of 1.206-9.607; and in model 4, the aOR was 2.741 with a 95% CI of 0.712-10.547. Exposure to higher levels of PM2.5 during pregnancy was associated with a tendency to worsen metabolic dysfunction markers specifically in glucose homeostasis. Further research is needed to investigate the mechanisms underlying the effects of ambient PM2.5 on metabolic dysfunction during pregnancy.
C1 [Jeong, Yeonseong] Yonsei Univ, Coll Med, Gangnam Severance Hosp, Dept Obstet & Gynecol, Seoul, South Korea.
   [Park, Sunwha; Kwon, Eunjin; Hur, Young Min; You, Young-Ah; Kim, Soo Min; Lee, Gain; Kim, Young Ju] Ewha Womans Univ, Ewha Med Res Inst, Coll Med, Dept Obstet & Gynecol, Seoul, South Korea.
   [Kim, Soo Min; Lee, Gain; Kim, Young Ju] Ewha Womans Univ, Grad Program Syst Hlth Sci & Engn, Seoul, South Korea.
   [Lee, Kyung A.; Kim, Soo Jung] Ewha Womans Univ, Seoul Hosp, Coll Med, Dept Obstet & Gynecol, Seoul, South Korea.
   [Cho, Geum Joon; Oh, Min-Jeong] Korea Univ, Guro Hosp, Coll Med, Dept Obstet & Gynecol, Seoul 152703, South Korea.
   [Na, Sung Hun; Lee, Se jin] Kangwon Natl Univ, Coll Med, Kangwon Natl Univ Hosp, Dept Obstet & Gynecol, Kangwon, South Korea.
   [Bae, Jin-Gon; Kim, Yu-Hwan] Keimyung Univ, Coll Med, Dongsan Med Ctr, Dept Diagnost Radiol, Taegu, South Korea.
   [Lee, Soo-Jeong] Univ Ulsan, Dept Obstet & Gynecol, Ulsan Univ Hosp, Coll Med, Ulsan, South Korea.
   [Kim, Young-Han] Yonsei Univ, Coll Med, Yonsei Univ Hlth Syst, Dept Obstet & Gynecol,Inst Womens Life Med Sci, Seoul 120752, South Korea.
C3 Yonsei University; Yonsei University Health System; Ewha Womans
   University; Ewha Womans University; Ewha Womans University; Korea
   University; Korea University Medicine (KU Medicine); Kangwon National
   University; Kangwon National University Hospital; Keimyung University;
   University of Ulsan; Ulsan University Hospital; Yonsei University;
   Yonsei University Health System
RP Kim, YJ (corresponding author), Ewha Womans Univ, Ewha Med Res Inst, Coll Med, Dept Obstet & Gynecol, Seoul, South Korea.; Kim, YJ (corresponding author), Ewha Womans Univ, Grad Program Syst Hlth Sci & Engn, Seoul, South Korea.
EM kkyj63@naver.com
RI Kim, Sara/F-2951-2013; Kim, Young/H-4235-2013; Lee,
   Soo-Jeong/A-4001-2015
OI Kim, Young-Han/0000-0003-0645-6028; Lee, Soo-Jeong/0000-0001-9272-6770;
   Yeonseong, Jeong/0000-0002-9978-6212
FU National Institute of health research project; Ewha Womans University
   Mokdong Hospital; Ewha Womans University Seoul Hospital, Korea
   University Guro Hospital; Keimyung University Dongsan Medical Center;
   Ulsan University Hospital
FX We are grateful to the APPO participants and staff at Yonsei University
   Hospital, Ewha Womans University Mokdong Hospital, Ewha Womans
   University Seoul Hospital, Korea University Guro Hospital, Kangwon
   National University Hospital, Keimyung University Dongsan Medical
   Center, and Ulsan University Hospital.
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NR 61
TC 2
Z9 2
U1 0
U2 8
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0944-1344
EI 1614-7499
J9 ENVIRON SCI POLLUT R
JI Environ. Sci. Pollut. Res.
PD DEC
PY 2023
VL 30
IS 59
BP 123907
EP 123924
DI 10.1007/s11356-023-30921-x
EA NOV 2023
PG 18
WC Environmental Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology
GA EM8L8
UT WOS:001117805600004
PM 37996573
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Xiao, L
   Mochizuki, M
   Fan, YM
   Nakahara, T
   Liao, F
AF Xiao, Li
   Mochizuki, Mai
   Fan, Yumei
   Nakahara, Taka
   Liao, Feng
TI Enzyme-digested Colla Corii Asini (E'jiao) suppresses
   lipopolysaccharide-induced inflammatory changes in THP-1 macrophages and
   OP9 adipocytes
SO HUMAN CELL
LA English
DT Article
DE Colla Corii Asini; LPS; Inflammation; Adiponectin; Inflammatory
   cytokines
ID HIGH-FAT DIET; ADIPOSE-TISSUE; INTESTINAL PERMEABILITY; 3T3-L1
   ADIPOCYTES; OXIDATIVE STRESS; GUT MICROBIOTA; CELLS; ADIPOGENESIS;
   OBESITY; LPS
AB Gut microbial lipopolysaccharides (LPS)-induced inflammatory responses in adipose tissue are associated with the dysfunction of adipocytes, insulin resistance and the development of metabolic syndrome. The aim of this study is to investigate (1) the effects of LPS on the differentiation and inflammatory responses of THP-1 monocytes and OP9 preadipocytes under serum free conditions and (2) the repressive effects of enzyme-digested Colla Corii Asini (CCAD) and fish gelatin (FGD) on LPS-induced inflammatory responses in THP-1 macrophages and OP9 adipocytes. Immunofluorescence and oil red O staining showed that a serum free medium supplied with phorbol 12-myristate 13-acetate (PMA) could induce differentiation and lipid accumulation in THP-1 cells as well as OP9 cells. ELISA showed that LPS significantly increased interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-alpha) secretions in PMA-differentiated THP-1 macrophages in a dose-dependent manner. LPS significantly suppressed lipid accumulation and adiponectin secretions, and enhanced IL-6 secretions in OP9 adipocytes. Both CCAD and FGD significantly reduced the levels of both macrophages- and adipocytes-derived inflammatory cytokines and increased the level of OP9-secreted adiponectin. In conclusion, LPS could induce inflammatory responses in both THP-1 and OP9 cells and cause dysfunction of OP9 adipocytes under the serum free conditions. CCAD and FGD can repress LPS-induced inflammatory responses in both THP-1 macrophages and OP9 adipocytes, and increase the secretion of adiponectin in OP9 adipocytes. They could be used as health care supplements for improving metabolic syndrome.
C1 [Xiao, Li] Nippon Dent Univ Tokyo, Sch Life Dent Tokyo, Dept Pharmacol, Chiyoda Ku, 1-9-20 Fujimi, Tokyo 1028159, Japan.
   [Mochizuki, Mai] Nippon Dent Univ Tokyo, Sch Life Dent Tokyo, Dept Life Sci Dent, Chiyoda Ku, 1-9-20 Fujimi, Tokyo 1028159, Japan.
   [Mochizuki, Mai; Nakahara, Taka] Nippon Dent Univ Tokyo, Sch Life Dent Tokyo, Dept Dev & Regenerat Dent, Chiyoda Ku, 1-9-20 Fujimi, Tokyo 1028159, Japan.
   [Fan, Yumei; Liao, Feng] Dong E E Jiao Co Ltd, Natl Engn Res Ctr Gelatin Based Tradit Chinese Me, Liaocheng, Shandong, Peoples R China.
C3 Nippon Dental University; Nippon Dental University; Nippon Dental
   University
RP Xiao, L (corresponding author), Nippon Dent Univ Tokyo, Sch Life Dent Tokyo, Dept Pharmacol, Chiyoda Ku, 1-9-20 Fujimi, Tokyo 1028159, Japan.; Liao, F (corresponding author), Dong E E Jiao Co Ltd, Natl Engn Res Ctr Gelatin Based Tradit Chinese Me, Liaocheng, Shandong, Peoples R China.
EM xiaoli@tky.ndu.ac.jp; mai-m@tky.ndu.ac.jp; t.nakahara@tky.ndu.ac.jp;
   liaofengcd@163.com
RI Xiao, Li/AAX-7766-2020; Nakahara, Taka/AAM-4112-2020; Mochizuki,
   Mai/AAU-7821-2020
OI Mochizuki, Mai/0000-0003-2071-8733; Liao, Feng/0000-0001-6251-6772
FU TaiShan Industrial Experts Program of China [TSCY20170233]; JSPS KAKENHI
   [21H03147, 21K17029]; Grants-in-Aid for Scientific Research [22K10009,
   21K17029, 21H03147, 23K21496] Funding Source: KAKEN
FX The present study was supported in part by TaiShan Industrial Experts
   Program of China No. TSCY20170233 and JSPS KAKENHI Grant-in-Aid for
   Scientific Research (B) (No. 21H03147 to T.N. and M.M.) and Grant-in-Aid
   for Young Scientists (B) (No. 21K17029 to M.M.). The authors also
   appreciate Nathaniel Green's proofreading.
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NR 39
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Z9 8
U1 2
U2 23
PU SPRINGER JAPAN KK
PI TOKYO
PA SHIROYAMA TRUST TOWER 5F, 4-3-1 TORANOMON, MINATO-KU, TOKYO, 105-6005,
   JAPAN
SN 0914-7470
EI 1749-0774
J9 HUM CELL
JI Hum. Cell
PD MAY
PY 2022
VL 35
IS 3
BP 885
EP 895
DI 10.1007/s13577-022-00694-5
EA APR 2022
PG 11
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA 0N5WJ
UT WOS:000777218200001
PM 35359251
DA 2025-06-11
ER

PT J
AU Yang, QH
   Ma, Q
   Xu, JA
   Liu, ZP
   Mao, XX
   Zhou, YQ
   Cai, YF
   Da, QE
   Hong, M
   Weintraub, NL
   Fulton, DJ
   de Chantemèle, EJB
   Huo, YQ
AF Yang, Qiuhua
   Ma, Qian
   Xu, Jiean
   Liu, Zhiping
   Mao, Xiaoxiao
   Zhou, Yaqi
   Cai, Yongfeng
   Da, Qingen
   Hong, Mei
   Weintraub, Neal L.
   Fulton, David J.
   de Chantemele, Eric J. Belin
   Huo, Yuqing
TI Endothelial AMPKα1/PRKAA1 exacerbates inflammation in HFD-fed mice
SO BRITISH JOURNAL OF PHARMACOLOGY
LA English
DT Article
DE AMPKA1; PRKAA1; endothelial cells; inflammation; metabolism
ID ACTIVATED PROTEIN-KINASE; INSULIN-RESISTANCE; CONCISE GUIDE; AMPK;
   INHIBITION; STRESS; CELLS; LIVER; DYSFUNCTION; GLYCOLYSIS
AB Background and Purpose Excess nutrient-induced endothelial cell inflammation is a hallmark of high fat diet (HFD)-induced metabolic syndrome. Pharmacological activation of the protein kinase AMP-activated alpha 1 (PRKAA1) also known as AMPK alpha 1, shows its beneficial effects in many studies of cardiometabolic disorders. However, AMPK alpha 1, as a major cellular sensor of energy and nutrients in endothelial cells, has not been studied for its physiological role in excess nutrient-induced endothelial cell (EC) inflammation. Experimental Approach Wild-type and EC-specific Prkaa1 knockout mice were fed with an HFD. Body weight, fat mass composition, glucose, and lipid levels were monitored regularly. Insulin sensitivity was analysed systemically and in major metabolic organs/tissues. Inflammation status in metabolic organs/tissues were examined with quantitative RT-PCR and flow cytometry. Additionally, metabolic status, inflammation severity, and signalling in cultured ECs were assayed with multiple approaches at the molecular level. Key Results EC Prkaa1 deficiency unexpectedly alleviated HFD-induced metabolic syndromes including decreased body weight and fat mass, enhanced glucose clearance and insulin sensitivity, and relieved adipose inflammation and hepatic steatosis. Mechanistically, PRKAA1 knockdown in cultured ECs reduced endothelial glycolysis and fatty acid oxidation, decreased levels of acetyl-CoA and suppressed transcription of inflammatory molecules mediated by ATP citrate lyase and histone acetyltransferase p300. Conclusions and Implications This unexpected pro-inflammatory effect of endothelial AMPK alpha 1/PRKAA1 in a metabolic context provides additional insight in AMPK alpha 1/PRKAA1 activities. An in-depth study and thoughtful consideration should be applied when AMPK alpha 1/PRKAA1 is used as a therapeutic target in the treatment of metabolic syndrome.
C1 [Yang, Qiuhua; Ma, Qian; Xu, Jiean; Liu, Zhiping; Mao, Xiaoxiao; Weintraub, Neal L.; Fulton, David J.; de Chantemele, Eric J. Belin; Huo, Yuqing] Augusta Univ, Med Coll Georgia, Vasc Biol Ctr, Dept Cellular Biol & Anat, Augusta, GA 30912 USA.
   [Ma, Qian; Xu, Jiean; Mao, Xiaoxiao; Zhou, Yaqi; Cai, Yongfeng; Hong, Mei] Peking Univ, State Key Lab Chem Oncogen, Key Lab Chem Genom, Shenzhen, Peoples R China.
   [Liu, Zhiping] Jinan Univ, Coll Pharm, Guangdong Prov Key Lab Pharmacodynam Constituents, Guangzhou, Peoples R China.
   [Da, Qingen] Peking Univ, Dept Cardiovasc Surg, Shenzhen Hosp, Shenzhen, Peoples R China.
C3 University System of Georgia; Augusta University; Peking University;
   Jinan University; Peking University
RP Huo, YQ (corresponding author), Augusta Univ, Med Coll Georgia, Vasc Biol Ctr, Dept Cellular Biol & Anat, Augusta, GA 30912 USA.
EM yhuo@augusta.edu
RI Li, Hong-Ye/AAX-2736-2020; MA, QIAN/HGC-0172-2022
OI cai, yongfeng/0000-0003-4187-3652; Liu, Zhiping/0000-0001-7272-6917;
   Zhou, Yaqi/0000-0003-0615-6631; Belin de Chantemele, Eric
   J./0000-0002-0184-3830; Yang, Qiuhua/0000-0002-5582-3771
FU American Heart Association [19TPA34910043]; National Institutes of
   Health [R01EY030500, R01HL134934]; American Heart Association (AHA)
   [19TPA34910043] Funding Source: American Heart Association (AHA)
FX American Heart Association, Grant/Award Number: 19TPA34910043; National
   Institutes of Health, Grant/Award Numbers: R01EY030500, R01HL134934
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NR 65
TC 11
Z9 11
U1 1
U2 16
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0007-1188
EI 1476-5381
J9 BRIT J PHARMACOL
JI Br. J. Pharmacol.
PD APR
PY 2022
VL 179
IS 8
BP 1661
EP 1678
DI 10.1111/bph.15742
EA DEC 2021
PG 18
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA ZT5MD
UT WOS:000734478800001
PM 34796475
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Giglio, RV
   Carruba, G
   Cicero, AFG
   Banach, M
   Patti, AM
   Nikolic, D
   Cocciadiferro, L
   Zarcone, M
   Montalto, G
   Stoian, AP
   Banerjee, Y
   Rizvi, AA
   Toth, PP
   Rizzo, M
AF Giglio, Rosaria Vincenza
   Carruba, Giuseppe
   Cicero, Arrigo F. G.
   Banach, Maciej
   Patti, Angelo Maria
   Nikolic, Dragana
   Cocciadiferro, Letizia
   Zarcone, Maurizio
   Montalto, Giuseppe
   Stoian, Anca Pantea
   Banerjee, Yajnavalka
   Rizvi, Ali A.
   Toth, Peter P.
   Rizzo, Manfredi
TI Pasta Supplemented with Opuntia ficus-indica Extract Improves
   Metabolic Parameters and Reduces Atherogenic Small Dense Low-Density
   Lipoproteins in Patients with Risk Factors for the Metabolic Syndrome: A
   Four-Week Intervention Study
SO METABOLITES
LA English
DT Article
DE cardiovascular risk; dyslipidemia; low-density lipoprotein cholesterol;
   nutraceuticals; Opuntia ficus-indica
ID CACTUS PEAR; ANTIOXIDANT BETALAINS; CLINICAL-SIGNIFICANCE;
   LIPID-ACCUMULATION; OXIDATIVE STRESS; LDL SIZE; CHOLESTEROL; SUBCLASSES;
   FRUIT; NUTRACEUTICALS
AB Food supplementation with Opuntia ficus-indica (OFI) has been associated with a significant reduction in total cholesterol, body fat, hyperglycemia and blood pressure. Since OFI may also have antioxidant and anti-atherogenic properties, we hypothesized that its supplementation might reduce atherogenic lipoproteins, including small, dense low-density lipoproteins (sdLDL). Forty-nine patients (13 men and 36 women, mean age: 56 +/- 5 years) with one or two criteria for the metabolic syndrome weekly consumed 500 g of pasta supplemented with 3% OFI extract (30% of insoluble polysaccharides with high antioxidant power) for 1 month. The full LDL subclass profile was assessed by gel electrophoresis (Lipoprint, Quantimetrix, Redondo Beach, CA, USA). After 1 month of pasta supplementation, waist circumference (p = 0.0297), plasma glucose (p < 0.0001), triglycerides (p = 0.0137), plasma creatinine (p = 0.0244), urea and aspartate transaminase (p < 0.0001 for each) significantly decreased. A percentage increase in larger, less atherogenic LDL-1 (p = 0.0002), with a concomitant reduction in smaller, denser LDL-2 (p < 0.0001) and LDL-3 (p = 0.0004), were found. LDL-4 and-5 decreased, although not significantly. This is the first intervention study suggesting that pasta enriched with an OFI extract may have beneficial effects on some metabolic parameters and the LDL particle sizes, reducing atherogenic sdLDL. Future studies will help to establish if these findings impact cardiovascular outcomes.
C1 [Giglio, Rosaria Vincenza; Patti, Angelo Maria; Nikolic, Dragana; Montalto, Giuseppe; Rizzo, Manfredi] Univ Palermo, Internal Med & Med Specialties PROMISE, Dept Hlth Promot Sci Maternal & Infantile Care, I-90127 Palermo, Italy.
   [Carruba, Giuseppe; Cocciadiferro, Letizia; Zarcone, Maurizio] ARNAS Civ Cristina & Benfratelli, Div Res & Internationalizat, I-90127 Palermo, Italy.
   [Cicero, Arrigo F. G.] Alma Mater Studiorum Univ Bologna, Med & Surg Sci Dept, I-40138 Bologna, Italy.
   [Banach, Maciej] Med Univ Lodz, WAM Univ Hosp Lodz, Dept Hypertens, PL-90419 Lodz, Poland.
   [Banach, Maciej] Polish Mothers Mem Hosp Res Inst PMMHRI Lodz, PL-93338 Lodz, Poland.
   [Stoian, Anca Pantea] Carol Davila Univ Med & Pharm, Dept Diabet Nutr & Metab Dis, Bucharest 050474, Romania.
   [Banerjee, Yajnavalka] Mohammed Bin Rashid Univ Med & Hlth Sci, Dept Biochem, Dubai 505055, U Arab Emirates.
   [Rizvi, Ali A.; Rizzo, Manfredi] Univ South Carolina, Sch Med, Div Endocrinol Diabet & Metab, Columbia, SC 29203 USA.
   [Rizvi, Ali A.] Emory Univ, Sch Med, Div Endocrinol Metab & Lipids, Atlanta, GA 30322 USA.
   [Toth, Peter P.] CGH Med Ctr, Sterling, IL 61081 USA.
   [Toth, Peter P.] Univ Illinois, Sch Med, Peoria, IL 60612 USA.
   [Toth, Peter P.] Johns Hopkins Univ, Sch Med, Baltimore, MD 21205 USA.
C3 University of Palermo; A.R.N.A.S. Ospedali Civico Di Cristina
   Benfratelli; University of Bologna; Medical University Lodz; Carol
   Davila University of Medicine & Pharmacy; University of South Carolina
   System; University of South Carolina Columbia; Emory University;
   University of Illinois System; University of Illinois Peoria; Johns
   Hopkins University
RP Nikolic, D (corresponding author), Univ Palermo, Internal Med & Med Specialties PROMISE, Dept Hlth Promot Sci Maternal & Infantile Care, I-90127 Palermo, Italy.
EM rosaria.vincenza.giglio@alice.it; giuseppe.carruba@arnascivico.it;
   afgcicero@gmail.com; Maciej.banach@iczmp.edu.pl;
   pattiangelomaria@gmail.com; dragana.nikolic@unipa.it;
   leticoccia@libero.it; zarcone7@gmail.com; giuseppe.montalto@unipa.it;
   ancastoian@yahoo.com; Yajnavalka.Banerjee@mbru.ac.ae;
   ali.abbas.rizvi@emory.edu; peter.toth@cghmc.com; manfredi.rizzo@unipa.it
RI Carruba, Giuseppe/AAB-5833-2022; Cicero, Arrigo/H-8244-2019; Banerjee,
   Yajnavalka/J-5890-2019; Rizvi, Ali/AFV-2240-2022; RIZZO,
   MANFREDI/GZL-0551-2022; Toth, Peter/GMW-6552-2022; Cocciadiferro,
   Letizia/AHD-9779-2022; Licata, Anna/ADF-0000-2022; Banach,
   Maciej/A-1271-2009; GIGLIO, Rosaria Vincenza/IAR-9444-2023; Pantea
   Stoian, Anca/H-5799-2017
OI RIZZO, Manfredi/0000-0002-9549-8504; Carruba,
   Giuseppe/0000-0002-7872-1436; GIGLIO, Rosaria
   Vincenza/0000-0002-7968-1480; Cicero, Arrigo Francesco
   Giuseppe/0000-0002-4367-3884; Rizvi, Ali/0000-0002-3714-0790; Nikolic,
   Dragana/0000-0001-9572-9651; Cocciadiferro, Letizia/0000-0003-0015-7916;
   Pantea Stoian, Anca/0000-0003-0555-526X; Zarcone,
   Maurizio/0000-0002-5311-1359; Banerjee, Yajnavalka/0000-0002-7546-8893
FU project DiMeSa (Dieta Mediterranea e Salute) "Valorization of typical
   products of Mediterranean Diet and their use for health and
   nutraceutical aims" [PON02_00451_3361785]; National Operative Programme
   (PON) Research and Competitiveness 2007-2013 [713/Ric]; Italian National
   Operational Programme for Research and Competitiveness 2007-2013 grant
   [PONa3_00210]
FX The authors want to thank Giuseppa Castellino, Roberta Chianetta and
   Stefania Speciale from the PROMISE Department, University of Palermo,
   Italy for the valuable contribution in a few steps of this study, as
   well as all the volunteers who participated in this study. Part of this
   work was carried out using instruments provided by project DiMeSa (Dieta
   Mediterranea e Salute) "Valorization of typical products of
   Mediterranean Diet and their use for health and nutraceutical aims",
   PON02_00451_3361785. This project was funded in the frame of the
   National Operative Programme (PON) Research and Competitiveness
   2007-2013, Notice 713/Ric. The Ministry of Education, University &
   Research (MIUR), Axis I-Support to structural changes, Operational
   Objective-Networks to strengthen the scientific and technological
   potential of Convergence Regions, The Action: High Technology Clusters
   and Related Networks. In addition, part of this work was carried out
   using instruments provided by the Euro-Mediterranean Institute of
   Science and Technology and funded with the Italian National Operational
   Programme for Research and Competitiveness 2007-2013 grant awarded to
   the project titled "CyberBrain-Polo di innovazione" (Project code:
   PONa3_00210, European Regional Development Fund).
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NR 83
TC 24
Z9 24
U1 0
U2 8
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2218-1989
J9 METABOLITES
JI Metabolites
PD NOV
PY 2020
VL 10
IS 11
AR 428
DI 10.3390/metabo10110428
PG 14
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA OW9OG
UT WOS:000593206700001
PM 33114614
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Pérez-Torres, I
   Torres-Narvaez, JC
   Guarner-Lans, V
   Díaz-Díaz, E
   Perezpeña-Diazconti, M
   Palacios, AR
   Manzano-Peck, L
AF Perez-Torres, Israel
   Carlos Torres-Narvaez, Juan
   Guarner-Lans, Veronica
   Diaz-Diaz, Eulises
   Perezpena-Diazconti, Mario
   Romero Palacios, Andrea
   Manzano-Peck, Linaloe
TI Myocardial Protection from Ischemia-Reperfusion Damage by the
   Antioxidant Effect of Hibiscus sabdariffa Linnaeus on
   Metabolic Syndrome Rats
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Article
ID FREE-RADICALS
AB Cardiovascular diseases (CVD) constitute one of the most prevalent health problems worldwide, being strongly associated with metabolic syndrome (MS). Oxidative stress (OS) is present in both CVD and MS. Infusions of Hibiscus sabdariffa Linnaeus (HSL) have antioxidant properties and could therefore decrease the presence of OS in these diseases. The aim of this study was to evaluate myocardial protection during ischemia/reperfusion due to the antioxidant effect of HSL infusion (3%) on a MS rat model induced by the administration of 30% sucrose in drinking water. We determined in control, MS, and MS + HSL rat hearts (n = 6 per group) cardiac mechanical performance (CMP), coronary vascular resistance (CVR), and activities of manganese and copper/zinc superoxide dismutases (Mn and Cu/Zn-SOD), peroxidases, glutathione peroxidase (GPx), catalase (CAT), glutathione s-transferase (GST), glutathione reductase (GR), and glutathione (GSH). We also determined lipoperoxidation (LPO), total antioxidant capacity (TAC), and the nitrate/nitrite ratio (NO3/NO2). The treatment with the HSL infusion restored the CMP (p = 0.01) and CVR (p = 0.04) and increased the Mn- (p = 0.02), Cu/Zn-SOD (p = 0.05), peroxidases (p = 0.04), GST (p = 0.02) activity, GHS (p = 0.02), TAC (p = 0.04), and NO3/NO2 (p = 0.01) and decreased the LPO (p = 0.02) in the heart of MS rats undergoing ischemia/reperfusion. The results suggest that the treatment with an infusion from HSL calices protects the cardiac function from damage by ischemia and reperfusion through the antioxidant activities of the substances it possesses. It favors antioxidant enzymatic activities and nonenzymatic antioxidant capacity.
C1 [Perez-Torres, Israel; Perezpena-Diazconti, Mario; Romero Palacios, Andrea; Manzano-Peck, Linaloe] Inst Nacl Cardiol Ignacio Chavez, Dept Pathol, Juan Badiano 1,Secc 16, Mexico City 14080, DF, Mexico.
   [Carlos Torres-Narvaez, Juan] Inst Nacl Cardiol Ignacio Chavez, Dept Pharmacol, Juan Badiano 1,Secc 16, Mexico City 14080, DF, Mexico.
   [Guarner-Lans, Veronica] Inst Nacl Cardiol Ignacio Chavez, Dept Physiol, Juan Badiano 1,Secc 16, Mexico City 14080, DF, Mexico.
   [Diaz-Diaz, Eulises] Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Reprod Biol, Vasco de Quiroga 15,Sect 16, Mexico City 14000, DF, Mexico.
C3 National Institute of Cardiology - Mexico; National Institute of
   Cardiology - Mexico; National Institute of Cardiology - Mexico;
   Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran -
   Mexico
RP Pérez-Torres, I (corresponding author), Inst Nacl Cardiol Ignacio Chavez, Dept Pathol, Juan Badiano 1,Secc 16, Mexico City 14080, DF, Mexico.
EM pertorisr@yahoo.com.mx
RI Guarner-Lans, Verónica/AFW-3723-2022; Pérez Torres, Israel/AAE-2579-2022
OI Perez-Torres, Israel/0000-0001-6510-2954; Guarner-Lans,
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NR 62
TC 16
Z9 16
U1 0
U2 2
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PY 2019
VL 2019
AR 1724194
DI 10.1155/2019/1724194
PG 13
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA HT8KK
UT WOS:000464812200001
PM 31049126
OA Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Esfandiari, S
   Bahadoran, Z
   Mirmiran, P
   Tohidi, M
   Azizi, F
AF Esfandiari, Saeed
   Bahadoran, Zahra
   Mirmiran, Parvin
   Tohidi, Maryam
   Azizi, Fereidoun
TI Adherence to the dietary approaches to stop hypertension trial (DASH)
   diet is inversely associated with incidence of insulin resistance in
   adults: the Tehran lipid and glucose study
SO JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION
LA English
DT Article
DE dietary approaches to stop hypertension; insulin resistance; insulin
ID OXIDATIVE STRESS; METABOLIC SYNDROME; SENSITIVITY; RISK; HOMEOSTASIS;
   PATTERNS; INDEX
AB Beneficial effects of Dietary Approaches to Stop Hypertension trial (DASH) diet on features of metabolic syndrome have been indicated in clinical studies. In this study, we aimed to assess possible association of DASH diet score and the risk of insulin resistance in an Iranian population. In this prospective cohort study, 927 adult men and women, were recruited. Fasting serum insulin and glucose were measured at baseline and again after 3 years. Usual dietary intakes were measured using a validated 168 item semi-quantitative food frequency questionnaire and DASH score was calculated. Multivariate logistic regression models were used to estimate the occurrence of the insulin resistance across tertiles of DASH diet. To investigate possible superiority of DASH score over other scoring system, we also assessed the association of healthy eating index and Mediterranean diet score with the risk of insulin resistance. Mean age of the participants was 40.34 +/- 12.14 years old. The incidence rate of insulin resistance was 12.8%. Participants with higher DASH score had also higher intakes of potassium, calcium, magnesium, fiber, and lower intakes of cholesterol (p<0.05). After 3-years of follow-up, a significant negative association was observed between DASH score and the risk insulin resistance in the highest compared to the lowest tertile (OR = 0.39, 95% CI = 0.20-0.76, p for trend = 0.007). There was no significant association between healthy eating index and Mediterranean diet score with the incidence of insulin resistance. In conclusion, adherence to the DASH dietary pattern may be associated with a lower risk of insulin resistance and its related metabolic outcomes.
C1 [Esfandiari, Saeed; Bahadoran, Zahra; Mirmiran, Parvin] Shahid Beheshti Univ Med Sci, Res Inst Endocrine Sci, Nutr & Endocrine Res Ctr, 19395-4763 POB,24 Shahid Erabi St,Yeman St, Tehran, Iran.
   [Bahadoran, Zahra] Shahid Beheshti Univ Med Sci, Res Inst Endocrine Sci, Student Res Comm, 19395-4763 POB,24 Shahid Erabi St,Yeman St, Tehran, Iran.
   [Tohidi, Maryam] Shahid Beheshti Univ Med Sci, Res Inst Endocrine Sci, Prevent Metab Disorders Res Ctr, 19395-4763 POB,24 Shahid Erabi St,Yeman St, Tehran, Iran.
   [Azizi, Fereidoun] Shahid Beheshti Univ Med Sci, Res Inst Endocrine Sci, Endocrine Res Ctr, 19395-4763 POB,24 Shahid Erabi St,Yeman St, Tehran, Iran.
C3 Shahid Beheshti University Medical Sciences; Shahid Beheshti University
   Medical Sciences; Shahid Beheshti University Medical Sciences; Shahid
   Beheshti University Medical Sciences
RP Bahadoran, Z; Mirmiran, P (corresponding author), Shahid Beheshti Univ Med Sci, Res Inst Endocrine Sci, Nutr & Endocrine Res Ctr, 19395-4763 POB,24 Shahid Erabi St,Yeman St, Tehran, Iran.; Bahadoran, Z (corresponding author), Shahid Beheshti Univ Med Sci, Res Inst Endocrine Sci, Student Res Comm, 19395-4763 POB,24 Shahid Erabi St,Yeman St, Tehran, Iran.
EM z.bahadoran@endocrine.ac.ir; mirmiran@endocrine.ac.ir
RI Tohidi, Maryam/V-2261-2019; Mirmiran, Parvin/V-1433-2019; Bahadoran,
   Zahra/V-2003-2019; Azizi, Fereidoun/ABD-4136-2021
OI Mirmiran, Parvin/0000-0003-2391-4924; Azizi,
   Fereidoun/0000-0002-6470-2517
FU National Research Council of the Islamic Republic of Iran [121];
   Research Institute for Endocrine Sciences, Shahid Beheshti University of
   Medical Sciences; Student Research Committee, Shahid Beheshti University
   of Medical Sciences, Tehran, Iran [1395/D/107800]
FX This study was supported by grant No. 121 from the National Research
   Council of the Islamic Republic of Iran and the Research Institute for
   Endocrine Sciences, Shahid Beheshti University of Medical Sciences. This
   study is related to the project No. 1395/D/107800 from Student Research
   Committee, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
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NR 37
TC 22
Z9 23
U1 1
U2 6
PU JOURNAL CLINICAL BIOCHEMISTRY & NUTRITION
PI KYOTO
PA KYOTO PREFECTURAL UNIV MED, GRAD SCH MEDICAL SCIENCE, DEPT MOLECULAR
   GASTROENTEROLOGY & HEPATOLOGY, KYOTO, 602-8566, JAPAN
SN 0912-0009
EI 1880-5086
J9 J CLIN BIOCHEM NUTR
JI J. Clin. Biochem. Nutr.
PD SEP 1
PY 2017
VL 61
IS 2
BP 123
EP 129
DI 10.3164/jcbn.16-95
PG 7
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA FJ4NB
UT WOS:000412716000007
PM 28955129
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Labazi, H
   Trask, AJ
AF Labazi, Hicham
   Trask, Aaron J.
TI Coronary microvascular disease as an early culprit in the
   pathophysiology of diabetes and metabolic syndrome
SO PHARMACOLOGICAL RESEARCH
LA English
DT Review
ID NF-KAPPA-B; MUSCLE-CELL DIFFERENTIATION; GLYCATION END-PRODUCTS;
   ENDOTHELIAL DYSFUNCTION; ANGIOTENSIN-II; VASCULAR DYSFUNCTION;
   RESISTANCE ARTERIES; OXIDATIVE STRESS; NITRIC-OXIDE; INDUCED
   HYPERTENSION
AB Metabolic syndrome (MetS) is a group of cardio-metabolic risk factors that includes obesity, insulin resistance, hypertension, and dyslipidemia; these are also a combination of independent coronary artery disease (CAD) risk factors. Alarmingly, the prevalence of MetS risk factors are increasing and a leading cause for mortality. In the vasculature, complications from MetS and type 2 diabetes (T2D) can be divided into microvascular (retinopathy and nephropathy) and macrovascular (cardiovascular diseases and erectile dysfunction). In addition to vascular and endothelial dysfunction, vascular remodeling and stiffness are also hallmarks of cardiovascular disease (CVD), and well-characterized vascular changes that are observed in the early stages of hypertension, T2D, and obesity [1-3]. In the heart, the link between obstructive atherosclerosis of coronary macrovessels and myocardial ischemia (MI) is well established. However, recent studies show that abnormalities in the coronary microcirculation are associated with functional and structural changes in coronary microvessels (classically defined as being <= 150-200 mu m internal diameter), which may cause or contribute to MI even in the absence of obstractive CAD. This suggests a prognostic value of an abnormal coronary microcirculation as an early sub-clinical culprit in the pathogenesis and progression of heart disease in T2D and MetS. The aim of this review is to summarize recent studies investigating the coronary microvascular remodeling in an early pre-atherosclerotic phase of MetS and T2D, and to explore potential mechanisms associated with the timing of coronary microvascular remodeling relative to that of the macrovasculature. (C) 2017 Elsevier Ltd. All rights reserved.
C1 [Labazi, Hicham; Trask, Aaron J.] Nationwide Childrens Hosp Columbus, Ctr Cardiovasc Res, Columbus, OH USA.
   [Labazi, Hicham; Trask, Aaron J.] Nationwide Childrens Hosp Columbus, Ctr Heart, Columbus, OH USA.
   [Trask, Aaron J.] Ohio State Univ, Dept Pediat, Columbus, OH 43210 USA.
C3 University System of Ohio; Ohio State University; Nationwide Childrens
   Hospital; University System of Ohio; Ohio State University; Nationwide
   Childrens Hospital; Research Institute at Nationwide Children's
   Hospital; Center for Cardiovascular & Pulmonary Research; University
   System of Ohio; Ohio State University
RP Trask, AJ (corresponding author), Ohio State Univ, Coll Med, Ctr Cardiovasc Res, 700 Childrens Dr,WB4135, Columbus, OH 43205 USA.; Trask, AJ (corresponding author), Ohio State Univ, Coll Med, Ctr Heart, Res Inst,Nationwide Childrens Hosp,Dept Pediat, 700 Childrens Dr,WB4135, Columbus, OH 43205 USA.
EM aaron.trask@nationwidechildrens.org
RI Trask, Aaron/I-4076-2013
OI Labazi, Hicham/0000-0002-3872-136X
FU National Institutes of Health [R00HL116769, S10OD023438]; Nationwide
   Children's Hospital
FX This work was supported by the National Institutes of Health
   (R00HL116769 and S10OD023438 to AJT) and Nationwide Children's Hospital
   (to AJT).
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NR 104
TC 62
Z9 72
U1 0
U2 41
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 1043-6618
EI 1096-1186
J9 PHARMACOL RES
JI Pharmacol. Res.
PD SEP
PY 2017
VL 123
BP 114
EP 121
DI 10.1016/j.phrs.2017.07.004
PG 8
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA FG6GC
UT WOS:000410469200013
PM 28700893
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Kucera, O
   Cervinkova, Z
AF Kucera, Otto
   Cervinkova, Zuzana
TI Experimental models of non-alcoholic fatty liver disease in rats
SO WORLD JOURNAL OF GASTROENTEROLOGY
LA English
DT Article
DE Animal model; High-fat diet; Methionine- and choline-deficient diet;
   Non-alcoholic fatty liver disease; Non-alcoholic steatohepatitis;
   Otsuka-Long-Evans-Tokushima fatty rats; Zucker rats
ID ACTIVATED RECEPTOR-ALPHA; CHOLINE-DEFICIENT DIET; ACID-DEFINED DIET;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; OXIDATIVE STRESS; HEPATIC
   STEATOSIS; ANIMAL-MODELS; INDUCED STEATOHEPATITIS; HYPERTENSIVE-RATS
AB Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in the Western world, and it persists at a high prevalence. NAFLD is characterised by the accumulation of triglycerides in the liver and includes a spectrum of histopathological findings, ranging from simple fatty liver through non-alcoholic steatohepatitis (NASH) to fibrosis and ultimately cirrhosis, which may progress to hepatocellular carcinoma. The pathogenesis of NAFLD is closely related to the metabolic syndrome and insulin resistance. Understanding the pathophysiology and treatment of NAFLD in humans has currently been limited by the lack of satisfactory animal models. The ideal animal model for NAFLD should reflect all aspects of the intricate etiopathogenesis of human NAFLD and the typical histological findings of its different stages. Within the past several years, great emphasis has been placed on the development of an appropriate model for human NASH. This paper reviews the widely used experimental models of NAFLD in rats. We discuss nutritional, genetic and combined models of NAFLD and their pros and cons. The choice of a suitable animal model for this disease while respecting its limitations may help to improve the understanding of its complex pathogenesis and to discover appropriate therapeutic strategies. Considering the legislative, ethical, economical and health factors of NAFLD, animal models are essential tools for the research of this disease. (C) 2014 Baishideng Publishing Group Inc. All rights reserved.
C1 [Kucera, Otto; Cervinkova, Zuzana] Charles Univ Prague, Fac Med Hradec Kralove, Dept Physiol, Hradec Kralove 50038, Czech Republic.
C3 Charles University Prague; University Hospital Hradec Kralove
RP Kucera, O (corresponding author), Charles Univ Prague, Fac Med Hradec Kralove, Dept Physiol, Simkova 870, Hradec Kralove 50038, Czech Republic.
EM kucerao@lfhk.cuni.cz
RI Kučera, Otto/S-3734-2016; Cervinkova, Zuzana/J-1480-2016
OI Cervinkova, Zuzana/0000-0002-3908-290X; Kucera, Otto/0000-0002-5251-5343
FU Programme PRVOUK [P37/02]
FX Supported by Programme PRVOUK P37/02
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NR 102
TC 144
Z9 165
U1 0
U2 35
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 8226 REGENCY DR, PLEASANTON, CA 94588 USA
SN 1007-9327
EI 2219-2840
J9 WORLD J GASTROENTERO
JI World J. Gastroenterol.
PD JUL 14
PY 2014
VL 20
IS 26
BP 8364
EP 8376
DI 10.3748/wjg.v20.i26.8364
PG 13
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA AL8LF
UT WOS:000339389500004
PM 25024595
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Yoshioka, J
   Chutkow, WA
   Lee, S
   Kim, JB
   Yan, J
   Tian, R
   Lindsey, ML
   Feener, EP
   Seidman, CE
   Seidman, JG
   Lee, RT
AF Yoshioka, Jun
   Chutkow, William A.
   Lee, Samuel
   Kim, Jae Bum
   Yan, Jie
   Tian, Rong
   Lindsey, Merry L.
   Feener, Edward P.
   Seidman, Christine E.
   Seidman, Jonathan G.
   Lee, Richard T.
TI Deletion of thioredoxin-interacting protein in mice impairs
   mitochondrial function but protects the myocardium from
   ischemia-reperfusion injury
SO JOURNAL OF CLINICAL INVESTIGATION
LA English
DT Article
ID CARBOHYDRATE RESPONSE ELEMENT; OXIDATIVE STRESS; PERMEABILITY
   TRANSITION; CARDIAC MITOCHONDRIA; PRESSURE-OVERLOAD; NITRIC-OXIDE;
   HELA-CELLS; EXPRESSION; GLUCOSE; DYSFUNCTION
AB Classic therapeutics for ischemic heart disease are less effective in individuals with the metabolic syndrome. As the prevalence of the metabolic syndrome is increasing, better understanding of cardiac metabolism is needed to identify potential new targets for therapeutic intervention. Thioredoxin-interacting protein (Txnip) is a regulator of metabolism and an inhibitor of the antioxidant thioredoxins, but little is known about its roles in the myocardium. We examined hearts from Txnip-KO mice by polony multiplex analysis of gene expression and an independent proteomic approach; both methods indicated suppression of genes and proteins participating in mitochondrial metabolism. Consistently, Txnip-KO mitochondria were functionally and structurally altered, showing reduced oxygen consumption and ultrastructural derangements. Given the central role that mitochondria play during hypoxia, we hypothesized that Txnip deletion would enhance ischemia-reperfusion damage. Surprisingly, Txnip-KO hearts had greater recovery of cardiac function after an ischemia-reperfusion insult. Similarly, cardiomyocyte-specific Txnip deletion reduced infarct size after reversible coronary ligation. Coordinated with reduced mitochondrial function, deletion of Txnip enhanced anaerobic glycolysis. Whereas mitochondrial ATP synthesis was minimally decreased by Txnip deletion, cellular ATP content and lactate formation were higher in Txnip-KO hearts after ischemia-reperfusion injury. Pharmacologic inhibition of glycolytic metabolism completely abolished the protection afforded the heart by Txnip deficiency under hypoxic conditions. Thus, although Txnip deletion suppresses mitochondrial function, protection from myocardial ischemia is enhanced as a result of a coordinated shift to enhanced anaerobic metabolism, which provides an energy source outside of mitochondria.
C1 [Yoshioka, Jun; Chutkow, William A.; Lee, Samuel; Kim, Jae Bum; Yan, Jie; Tian, Rong; Seidman, Christine E.; Lee, Richard T.] Brigham & Womens Hosp, Div Cardiovasc, Boston, MA 02115 USA.
   [Lindsey, Merry L.] Univ Texas Hlth Sci Ctr UTHSCSA, Dept Med, Div Cardiol, San Antonio, TX USA.
   [Feener, Edward P.] Joslin Diabet Ctr, Div Res, Boston, MA 02215 USA.
   [Seidman, Christine E.; Seidman, Jonathan G.] Harvard Univ, Sch Med, Dept Genet, Boston, MA USA.
   [Lee, Richard T.] Harvard Stem Cell Inst, Cambridge, MA USA.
C3 Harvard University; Harvard University Medical Affiliates; Brigham &
   Women's Hospital; University of Texas System; University of Texas Health
   Science Center at San Antonio; Harvard University; Harvard University
   Medical Affiliates; Joslin Diabetes Center, Inc.; Harvard University;
   Harvard Medical School; Harvard University
RP Lee, RT (corresponding author), 65 Landsdowne St,Room 279, Cambridge, MA 02139 USA.
EM rlee@partners.org
RI Seidman, Jon/JXN-4736-2024; Kim, Jihyun/F-6940-2013; Tian,
   Rong/ABH-1383-2020; Lindsey, Merry/B-2650-2012
OI Tian, Rong/0000-0002-3676-3830; Lindsey, Merry/0000-0002-4090-0391; Lee,
   Richard/0000-0003-4687-1381; Lee, Samuel/0000-0001-6768-7079
FU American Heart Association [0835484N]; Deutsche Forschungsgemeinschaft
   [LE 2728/1-1]; NIH [HL088977, NHLBI268201000036C-0-0-1, HL048743,
   HL103582]; American Heart Association (AHA) [0835484N] Funding Source:
   American Heart Association (AHA)
FX We thank Hayden Huang (Columbia University) and Kenichi Imahashi
   (National Institute of Environmental Health Sciences) for their
   technical advice. We also thank Joseph Gannon and Qiuxia Dai for their
   technical assistance. This work was supported by American Heart
   Association Scientist Development Grant 0835484N (to J. Yoshioka);
   Deutsche Forschungsgemeinschaft LE 2728/1-1 (to S. Lee); and NIH grants
   HL088977 (to W.A. Chutkow), NHLBI268201000036C-0-0-1 for the UTHSCSA
   Cardiovascular Proteomics Center (to M.L. Lindsey), and HL048743 and
   HL103582 (to R.T. Lee).
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NR 56
TC 129
Z9 147
U1 0
U2 23
PU AMER SOC CLINICAL INVESTIGATION INC
PI ANN ARBOR
PA 2015 MANCHESTER RD, ANN ARBOR, MI 48104 USA
SN 0021-9738
EI 1558-8238
J9 J CLIN INVEST
JI J. Clin. Invest.
PD JAN
PY 2012
VL 122
IS 1
BP 267
EP 279
DI 10.1172/JCI44927
PG 13
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 871WW
UT WOS:000298769400030
PM 22201682
OA Green Accepted, Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Hevener, AL
   Febbraio, MA
AF Hevener, A. L.
   Febbraio, M. A.
CA Stock Conference Working Grp
TI The 2009 Stock Conference Report: Inflammation, Obesity and Metabolic
   Disease
SO OBESITY REVIEWS
LA English
DT Article
DE Inflammation; insulin resistance; metabolic syndrome; obesity
ID ACID-BINDING PROTEINS; INDUCED INSULIN-RESISTANCE; HEAT-SHOCK PROTEINS;
   GROWTH-FACTOR 21; RECEPTOR-ALPHA GENE; BETA-CELL APOPTOSIS;
   SKELETAL-MUSCLE; NEUROTROPHIC FACTOR; ADIPOSE-TISSUE; SATURATED-FAT
AB P>Obesity is linked with many deleterious health consequences and is associated with increased risk of chronic disease including type 2 diabetes, atherosclerosis and certain forms of cancer. Recent work has highlighted the impact of obesity to activate inflammatory gene networks and suggests a causal function of inflammation in the pathogenesis of the metabolic syndrome. Since 2005, when Dr Gokhan Hotamisligil chaired the fourth Stock Conference in Istanbul, Turkey, entitled 'Obesity and Inflammation', there has been an explosion of studies investigating the relationship between obesity, inflammation and substrate metabolism. The exuberance surrounding this field of research is exemplified by the body of work that has been published in these past 4 years, including over 1400 publications. During this time, several novel mechanisms relating to cellular inflammation have been uncovered including the role of the hematopoietic system, toll-like receptor activation, endoplasmic reticulum stress and very recently T-cell activation in obesity-induced insulin resistance. These discoveries have led us to rethink cellular nutrient sensing and its role in inflammation and metabolic disease. Despite burgeoning investigation in this field, there still remain a number of unanswered questions. This review that evolved from the 2009 Stock Conference summarizes current research and identifies the deficiencies in our understanding of this topic. The overall goal of this Stock Conference was to bring together leading investigators in the field of inflammation and obesity research in the hope of fostering new ideas, thus advancing the pursuit of novel therapeutic strategies to reduce disease risk and or better treat chronic disease including type 2 diabetes, cardiovascular disease and cancer.
C1 [Hevener, A. L.] Univ Calif Los Angeles, David Geffen Sch Med, Div Endocrinol Diabet & Hypertens, Los Angeles, CA 90095 USA.
   [Febbraio, M. A.] Baker IDI Heart & Diabet Inst, Melbourne, Vic, Australia.
C3 University of California System; University of California Los Angeles;
   University of California Los Angeles Medical Center; David Geffen School
   of Medicine at UCLA; Baker Heart and Diabetes Institute
RP Hevener, AL (corresponding author), Univ Calif Los Angeles, David Geffen Sch Med, Div Endocrinol Diabet & Hypertens, 900 Veteran Ave,Warren Hall Suite 24-130, Los Angeles, CA 90095 USA.
EM ahevener@mednet.ucla.edu; mark.febbraio@bakeridi.edu.au
RI Febbraio, Mark/AAE-9632-2019
OI Febbraio, Mark/0000-0002-9296-4418
FU Astra Zeneca; GlaxoSmithKline
FX The authors would like to thank Mr Marco Presutto from the IASO London
   office for his outstanding work in organizing such a successful meeting,
   and Dr David York who has coordinated the Stock Conferences for many
   years. In addition we would like to thank the sponsors, Astra Zeneca and
   GlaxoSmithKline for their financial support in making this meeting
   possible. Lastly we would like to thank our distinguished speakers and
   all of the participants attending the 2009 Stock Conference for their
   intellectual contributions and thoughtful discussions during the
   meeting.
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NR 67
TC 40
Z9 47
U1 0
U2 13
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1467-7881
EI 1467-789X
J9 OBES REV
JI Obes. Rev.
PD SEP
PY 2010
VL 11
IS 9
BP 635
EP 644
DI 10.1111/j.1467-789X.2009.00691.x
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 643HE
UT WOS:000281285400002
PM 20002885
OA Bronze
DA 2025-06-11
ER

PT J
AU Jun, J
   Polotsky, VY
AF Jun, Jonathan
   Polotsky, Vsevolod Y.
TI Metabolic Consequences of Sleep-Disordered Breathing
SO ILAR JOURNAL
LA English
DT Review
DE diabetes; intermittent hypoxia; metabolic syndrome; metabolism; obesity;
   risk factor; rodent model; sleep apnea
ID POSITIVE AIRWAY PRESSURE; CHRONIC INTERMITTENT HYPOXIA; NONALCOHOLIC
   FATTY LIVER; C-REACTIVE PROTEIN; SERUM AMINOTRANSFERASE LEVELS;
   CARDIOVASCULAR RISK-FACTORS; STEAROYL-COA DESATURASE-1; FACTOR-KAPPA-B;
   SYMPATHETIC-NERVOUS-SYSTEM; INDUCED INSULIN-RESISTANCE
AB There is increasing evidence of a causal relationship between sleep-disordered breathing and metabolic dysfunction. Metabolic syndrome (MetS), a cluster of risk factors that promote atherosclerotic cardiovascular disease, comprises central obesity, insulin resistance, glucose intolerance, dyslipidemia, and hypertension, manifestations of altered total body energy regulation. Excess caloric intake is indisputably the key driver of MetS, but other environmental and genetic factors likely play a role; in particular, obstructive sleep apnea (OSA), characterized by intermittent hypoxia (IH), may induce or exacerbate various aspects of MetS. Clinical studies show that OSA can affect glucose metabolism, cholesterol, infl ammatory markers, and nonalcoholic fatty liver disease. Animal models of OSA enable scientists to circumvent confounders such as obesity in clinical studies. In the most widely used model, which involves exposing rodents to IH during their sleep phase, the IH alters circadian glucose homeostasis, impairs muscle carbohydrate uptake, induces hyperlipidemia, and upregulates cholesterol synthesis enzymes. Complicating factors such as obesity or a high-fat diet lead to progressive insulin resistance and liver infl ammation, respectively. Mechanisms for these effects are not yet fully understood, but are likely related to energy-conserving adaptations to hypoxia, which is a strong catabolic stressor. Finally, IH may contribute to the morbidity of MetS by inducing infl ammation and oxidative stress. Identifi cation of OSA as a potential causative factor in MetS would have immense clinical impact and could improve the management and understanding of both disorders.
C1 [Jun, Jonathan; Polotsky, Vsevolod Y.] Johns Hopkins Univ, Sch Med, Div Pulm & Crit Care Med, Baltimore, MD USA.
C3 Johns Hopkins University
RP Jun, J (corresponding author), Johns Hopkins Pulm & Crit Care Med, 5501 Hopkins Bayview Circle 5A-42A, Baltimore, MD 21224 USA.
EM jjun2@jhmi.edu
FU National Institutes of Health (NIH) [T32 HL07534, SF-78568-N, RO1
   HL80105, 5P50HL084945]; American Heart Association [0765293U]; American
   Heart Association (AHA) [0765293U] Funding Source: American Heart
   Association (AHA)
FX Jonathan Jun received funding from the National Institutes of Health
   (NIH; grants T32 HL07534 and SF-78568-N), and Vsevolod Y. Polotsky from
   NIH (RO1 HL80105, 5P50HL084945) and the American Heart Association
   (grant 0765293U).
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NR 239
TC 79
Z9 82
U1 0
U2 9
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1084-2020
EI 1930-6180
J9 ILAR J
JI ILAR J.
PY 2009
VL 50
IS 3
BP 289
EP 306
DI 10.1093/ilar.50.3.289
PG 18
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA 472JB
UT WOS:000268125400005
PM 19506316
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Waters, KA
   Mast, BT
   Vella, S
   De la Eva, R
   O'Brien, LM
   Bailey, S
   Tam, CS
   Wong, M
   Baur, LA
AF Waters, Karen A.
   Mast, Benjamin T.
   Vella, Silvano
   De la Eva, Roland
   O'Brien, Louise M.
   Bailey, Sherryn
   Tam, Charmaine S.
   Wong, Melanie
   Baur, Louise A.
TI Structural equation modeling of sleep apnea, inflammation, and metabolic
   dysfunction in children
SO JOURNAL OF SLEEP RESEARCH
LA English
DT Article
DE children; inflammation; metabolic syndrome; obstructive sleep apnea;
   structural equation model
ID POSITIVE AIRWAY PRESSURE; CARDIOVASCULAR RISK; INSULIN-RESISTANCE;
   GLUCOSE-INTOLERANCE; OXIDATIVE STRESS; CYTOKINE LEVELS; SERUM LEPTIN;
   OBESITY; DISEASE; CHILDHOOD
AB Obstructive sleep apnea (OSA), often concomitant with obesity, increases the risk for the metabolic syndrome. One mechanism that may participate in this association is upregulation of inflammatory pathways. We used structural equation modeling to assess the interrelations between childhood obesity, OSA, inflammation, and metabolic dysfunction. One hundred and eighty-four children (127 boys, mean age: 8.5 +/- 4.1years) had height and weight measured, underwent overnight polysomnography and had fasting blood taken. The blood was analyzed for insulin, glucose, lipids, leptin, and cytokines [interferon (IFN)-gamma, granulocyte macrophage-colony stimulating factor, interleukin (IL)-1 beta, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12, tumor necrosis factor-alpha]. Structural equation modeling (SEM) was used to evaluate associations between the outcomes of interest including hypoxia, arousal (related to respiratory and spontaneous), obesity, metabolic dysfunction, and inflammatory markers. Two cytokine factors and one metabolic factor were derived for the SEM. These factors provided good fit in the structural equation model (chi(2)/df = 2.855; comparative fit index = 0.90, root mean squared error of approximation = 0.10) and all factor loadings were significantly different from zero (P <= 0.01). Overall, our results indicate that while obesity (as measured by body mass index z-score) has a major influence on the metabolic dysfunction associated with OSA, arousal indices, and cytokine markers may also influence this association. Our results support the hypothesis that OSA is a contributor to the mechanisms that link sleep, systemic inflammation and insulin resistance, and show that the interrelations may begin in childhood.
C1 Univ Louisville, Kosair Childrens Hosp Res Inst, Div Gen Pediat Sleep Med, Dept Pediat, Louisville, KY USA.
   Univ Sydney, Childrens Hosp Westmead, SIDS & Sleep Apnea Res, Sydney, NSW 2006, Australia.
   Univ Sydney, Fac Med, Sydney, NSW 2006, Australia.
   Univ Louisville, Dept Psychol & Brain Sci, Louisville, KY USA.
   Childrens Hosp Westmead, Dept Immunol, Westmead, NSW, Australia.
C3 University of Louisville; University of Sydney; NSW Health; The
   Children's Hospital at Westmead; University of Sydney; University of
   Louisville; NSW Health; Sydney Childrens Hospitals Network; University
   of Sydney; The Children's Hospital at Westmead
RP Waters, KA (corresponding author), Univ Louisville, Sch Med, Kosair Childrens Hosp Res Inst, 571 S Preston St Suite 321, Louisville, KY 40202 USA.
EM kaw@med.usyd.edu.au
RI Baur, Louise/AAE-3413-2021; Waters, Karen/B-2840-2013
OI Bailey, Sherryn/0000-0003-2154-0586; Waters, Karen/0000-0001-8699-2175;
   Baur, Louise/0000-0002-4521-9482
FU NHLBI NIH HHS [HL 070784] Funding Source: Medline
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NR 51
TC 56
Z9 58
U1 1
U2 14
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0962-1105
EI 1365-2869
J9 J SLEEP RES
JI J. Sleep Res.
PD DEC
PY 2007
VL 16
IS 4
BP 388
EP 395
DI 10.1111/j.1365-2869.2007.00614.x
PG 8
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 234ZM
UT WOS:000251203300007
PM 18036084
OA Bronze
DA 2025-06-11
ER

PT J
AU Liu, QJ
   Sun, L
   Tan, Y
   Wang, GJ
   Lin, X
   Cai, L
AF Liu, Qiuju
   Sun, Liang
   Tan, Yi
   Wang, Guanjun
   Lin, Xu
   Cai, Lu
TI Role of Iron Deficiency and Overload in the Pathogenesis of Diabetes and
   Diabetic Complications
SO CURRENT MEDICINAL CHEMISTRY
LA English
DT Review
DE Diabetes; diabetic complications; insulin resistance; iron deficiency;
   iron overload; iron; ferritin; anemia
ID INSULIN-RESISTANCE SYNDROME; MITOCHONDRIAL-MEMBRANE PROTEIN;
   CORONARY-HEART-DISEASE; SERUM FERRITIN; ANGIOTENSIN-II; HEME OXYGENASE;
   BLOOD-DONATION; GLUCOSE-METABOLISM; UP-REGULATION; VITAMIN-A
AB Iron is one of the essential minerals that are required for a variety of molecules to maintain their normal structures and functions and for cells to live, grow, and proliferate. The homeostasis of iron results from a tightly coordinated regulation by different proteins involved in uptake, excretion and intracellular storage/trafficking. Although it is essential, iron can also be toxic once in excess amounts. Through Fenton reaction, iron as a transit mineral can generate various reactive oxygen or nitrogen species; therefore, abnormal metabolism of iron can lead to several chronic pathogenesis. Oxidative stress is one of the major causative factors for diabetes and diabetic complications. Increasing evidence has indicated that iron overload not only increases risks of insulin resistance and diabetes, but also causes cardiovascular diseases in non-diabetic and diabetic subjects. Temporal iron deficiency was found to sensitize insulin action, but chronic iron deficiency with anemia can accelerate the development of cardiovascular diseases in non-diabetic and diabetic patients. In this review, therefore, we will first outline iron homeostasis, function, and toxicity, and then mainly summarize the data regarding the roles of iron deficiency and overload in the pathogenesis of diabetes and diabetic complications, as well as the possible links of iron to diabetes and diabetic complications. In the end, the possible therapy using iron chelators for diabetes and diabetic complications will also be discussed.
C1 [Liu, Qiuju; Tan, Yi; Cai, Lu] Univ Louisville, Dept Med, Louisville, KY 40292 USA.
   [Liu, Qiuju; Tan, Yi; Cai, Lu] Univ Louisville, Dept Radiat Oncol, Louisville, KY 40292 USA.
   [Liu, Qiuju; Tan, Yi; Cai, Lu] Univ Louisville, Dept Pharmacol & Toxicol, Louisville, KY 40292 USA.
   [Sun, Liang; Lin, Xu] Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Key Lab Nutr & Metab, Shanghai, Peoples R China.
   [Sun, Liang; Lin, Xu] Chinese Acad Sci, Grad Univ, Shanghai, Peoples R China.
   [Liu, Qiuju; Wang, Guanjun; Cai, Lu] Jilin Univ, Hosp 1, Changchun 130023, Peoples R China.
   [Liu, Qiuju] Jilin Univ, Hosp 2, Changchun 130023, Peoples R China.
C3 University of Louisville; University of Louisville; University of
   Louisville; Chinese Academy of Sciences; Chinese Academy of Sciences;
   University of Chinese Academy of Sciences, CAS; Jilin University; Jilin
   University
RP Lin, X (corresponding author), 511 S Floyd St,MDR 533, Louisville, KY 40202 USA.
EM xlin@sibs.ac.cn; L0cai001@louisville.edu
RI Li, Junle/JJE-0266-2023; lin, xu/KOC-3517-2024; Cai, Lu/AAG-9920-2019
FU American Diabetes Association [02-07-JF-02, 05-07-CD-02]; CAS/SAFEA
   International Partnership Program for Creative Research Team; China
   Scholarship Council
FX The work in the authors' laboratories was supported, in part, by
   research grants from American Diabetes Association (02-07-JF-02;
   05-07-CD-02, to L. Cai) and from the CAS/SAFEA International Partnership
   Program for Creative Research Team (to X. Lin & L. Cai). Q.J. Liu is a
   recipient of Scholarship under State Scholarship Fund from China
   Scholarship Council.
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NR 152
TC 119
Z9 130
U1 1
U2 29
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 0929-8673
EI 1875-533X
J9 CURR MED CHEM
JI Curr. Med. Chem.
PD JAN
PY 2009
VL 16
IS 1
BP 113
EP 129
DI 10.2174/092986709787002862
PG 17
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Pharmacology &
   Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
GA 406KP
UT WOS:000263294600006
PM 19149565
DA 2025-06-11
ER

PT J
AU Motairek, I
   Makhlouf, MHE
   Rajagopalan, S
   Al-Kindi, S
AF Motairek, Issam
   Makhlouf, Mohamed H. E.
   Rajagopalan, Sanjay
   Al-Kindi, Sadeer
TI The Exposome and Cardiovascular Health
SO CANADIAN JOURNAL OF CARDIOLOGY
LA English
DT Review
ID AMBIENT AIR-POLLUTION; PARTICULATE MATTER; FOOD INSECURITY;
   UNITED-STATES; MYOCARDIAL-INFARCTION; METABOLIC SYNDROME;
   BLOOD-PRESSURE; SHORT-TERM; US ADULTS; MORTALITY
AB The study of the interplay between social factors, environmental hazards, and health has garnered much attention in recent years. The term "exposome" was coined to describe the total impact of environ-mental exposures on an individual's health and well-being, serving as a complementary concept to the genome. Studies have shown a strong correlation between the exposome and cardiovascular health, with various components of the exposome having been implicated in the development and progression of cardiovascular disease. These components include the natural and built environment, air pollution, diet, physical activity, and psychosocial stress, among others. This review provides an overview of the relationship between the exposome and cardiovascular health, highlighting the epidemiologic and mechanistic evidence of environmental exposures on cardiovascular disease. The interplay between various environmental components is discussed, and potential avenues for mitigation are identified.
C1 Univ Hosp Cleveland Med Ctr, Harrington Heart & Vasc Inst, Cleveland, OH USA.
   Case Western Reserve Univ, Sch Med, Cleveland, OH USA.
C3 University Hospitals of Cleveland; University System of Ohio; Case
   Western Reserve University
RP Al-Kindi, S (corresponding author), Case Western Reserve Univ, Sch Med, Univ Hosp, Harrington Heart & Vasc Inst,Med, 11100 Euclid Ave, Cleveland, OH 44106 USA.
EM sadeer.al-kindi@uhhospitals.org
RI Al-Kindi, Sadeer/AAO-9192-2020
FU National Institute on Minority Health and Health Disparities
   [P50MD017351]
FX This work was partly funded by the National Institute on Minority Health
   and Health Disparities Award no. P50MD017351.
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NR 109
TC 16
Z9 16
U1 2
U2 6
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0828-282X
EI 1916-7075
J9 CAN J CARDIOL
JI Can. J. Cardiol.
PD SEP
PY 2023
VL 39
IS 9
BP 1191
EP 1203
DI 10.1016/j.cjca.2023.05.020
EA SEP 2023
PG 13
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA S8IL5
UT WOS:001073547800001
PM 37290538
OA Bronze, Green Accepted
DA 2025-06-11
ER

PT J
AU Katsiki, N
   Steiropoulos, P
   Papanas, N
   Mikhailidis, DP
AF Katsiki, Niki
   Steiropoulos, Paschalis
   Papanas, Nikolaos
   Mikhailidis, Dimitri P.
TI Diabetes Mellitus and Chronic Obstructive Pulmonary Disease: An Overview
SO EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
LA English
DT Review
DE chronic obstructive pulmonary disease; obesity; type 2 diabetes mellitus
ID LUNG-FUNCTION; INHALED CORTICOSTEROIDS; SYSTEMIC INFLAMMATION; ACUTE
   EXACERBATIONS; INSULIN-RESISTANCE; METABOLIC SYNDROME; INCREASED RISK;
   BODY-WEIGHT; COPD; OBESITY
AB Chronic obstructive pulmonary disease (COPD) is a common disease with an increasing prevalence, characterised by persistent respiratory symptoms and airflow limitation. Apart from cigarette smoking, certain occupational and environmental exposures, low socioeconomic status and genetic factors may contribute to the pathogenesis of COPD. Comorbidities, e. g. diabetes mellitus (DM), can negatively affect quality of life, COPD outcomes and cardiovascular risk. The present narrative review considers the potential links between COPD and DM, such as systemic inflammation, oxidative stress, hypoxaemia and hyperglycaemia. The effects of antidiabetic drugs on lung function and COPD outcomes, as well as the possibility of common therapeutic modalities are also briefly considered. Further research is needed in this field to elucidate these relationships as well as their potential clinical implications in daily practice.
C1 [Katsiki, Niki] AHEPA Univ Hosp, Diabet Ctr, Dept Internal Med 1, Div Endocrinol & Metab, Thessaloniki, Greece.
   [Steiropoulos, Paschalis] Democritus Univ Thrace Sch Hlth Sci, Dept Pneumonol, Alexandroupolis, Greece.
   [Papanas, Nikolaos] Democritus Univ Thrace, Diabet Ctr, Dept Internal Med 2, Alexandroupolis, Greece.
   [Mikhailidis, Dimitri P.] UCL, Dept Clin Biochem, Royal Free Hosp Campus, London, England.
C3 Aristotle University of Thessaloniki; Ahepa University Hospital;
   Democritus University of Thrace; University of London; University
   College London; Royal Free London NHS Foundation Trust
RP Papanas, N (corresponding author), Democritus Univ Thrace, Univ Hosp Alexandroupolis, Dept Internal Med 2, Diabet Ctr, Alexandroupolis 68100, Greece.
EM papanasnikos@yahoo.gr
RI Steiropoulos, Paschalis/AAH-6905-2021; KATSIKI, NIKI/ADE-7999-2022
OI KATSIKI, NIKI/0000-0003-0894-2644
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NR 97
TC 15
Z9 17
U1 1
U2 26
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0947-7349
EI 1439-3646
J9 EXP CLIN ENDOCR DIAB
JI Exp. Clin. Endocrinol. Diabet.
PD OCT
PY 2021
VL 129
IS 10
BP 699
EP 704
DI 10.1055/a-1038-3883
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA WA9ZS
UT WOS:000703241900001
PM 31739346
DA 2025-06-11
ER

PT J
AU Snaith, JR
   Holmes-Walker, DJ
   Greenfield, JR
AF Snaith, Jennifer R.
   Holmes-Walker, Deborah J.
   Greenfield, Jerry R.
TI Reducing Type 1 Diabetes Mortality: Role for Adjunctive Therapies?
SO TRENDS IN ENDOCRINOLOGY AND METABOLISM
LA English
DT Review
ID CORONARY-ARTERY CALCIFICATION; 10-YEAR FOLLOW-UP; CARDIOVASCULAR
   OUTCOMES; INSULIN-RESISTANCE; ENDOTHELIAL FUNCTION; GLYCEMIC
   VARIABILITY; VASCULAR BIOMARKERS; METABOLIC SYNDROME; OXIDATIVE STRESS;
   GLUCOSE CONTROL
AB Individuals with type 1 diabetes (T1D) frequently fail to achieve glycemic goals and have excess cardiovascular risk and premature death. Adjunctive agents may play a role in reducing morbidity, mortality, and the adverse sequelae of insulin treatment. A surge in type 2 diabetes drug development has revealed agents with benefits beyond glucose lowering, including cardiovascular risk reduction. Could these benefits translate to T1D? Specific trials for T1D demonstrate substantial hemoglobin (Hb) A1c reductions with sodium glucose cotransporter inhibitors (SGLTis) and glucagon-like peptide (GLP)1 agonists, and modest improvements with metformin, dipeptidyl peptidase-4 inhibitor (DPP4i), and pramlintide. Studies exploring cardiovascular risk reduction are warranted. This review synthesizes the emerging literature for researchers and clinicians treating people with T1D. Challenges in T1D research are discussed.
C1 [Snaith, Jennifer R.; Greenfield, Jerry R.] Garvan Inst Med Res, Diabet & Metab, Sydney, NSW, Australia.
   [Snaith, Jennifer R.; Holmes-Walker, Deborah J.] Westmead Hosp, Dept Diabet & Endocrinol, Sydney, NSW, Australia.
   [Snaith, Jennifer R.; Greenfield, Jerry R.] St Vincents Hosp, Dept Diabet & Endocrinol, Sydney, NSW, Australia.
   [Snaith, Jennifer R.; Greenfield, Jerry R.] Univ New South Wales, Fac Med, St Vincents Clin Sch, Sydney, NSW, Australia.
   [Snaith, Jennifer R.; Holmes-Walker, Deborah J.] Univ Sydney, Fac Med, Sydney, NSW, Australia.
C3 Garvan Institute of Medical Research; NSW Health; Westmead Hospital;
   University of Sydney; NSW Health; St Vincents Hospital Sydney;
   University of New South Wales Sydney; University of Sydney
RP Greenfield, JR (corresponding author), Garvan Inst Med Res, Diabet & Metab, Sydney, NSW, Australia.; Greenfield, JR (corresponding author), St Vincents Hosp, Dept Diabet & Endocrinol, Sydney, NSW, Australia.; Greenfield, JR (corresponding author), Univ New South Wales, Fac Med, St Vincents Clin Sch, Sydney, NSW, Australia.
EM j.greenfield@garvan.org.au
RI Snaith, Jennifer/V-6652-2018
OI Snaith, Jennifer/0000-0001-8559-8387; Holmes-Walker, Deborah
   Jane/0000-0002-3640-1370
FU Don Chisholm Fellowship; University Postgraduate Award (University of
   New South Wales)
FX J.R.G. is partly supported by the Don Chisholm Fellowship. J.R.S. is
   supported by the University Postgraduate Award (University of New South
   Wales). We are thankful to the reviewers of this manuscript for their
   constructive feedback.
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NR 96
TC 31
Z9 32
U1 0
U2 3
PU CELL PRESS
PI CAMBRIDGE
PA 50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA
SN 1043-2760
EI 1879-3061
J9 TRENDS ENDOCRIN MET
JI Trends Endocrinol. Metab.
PD FEB
PY 2020
VL 31
IS 2
BP 150
EP 164
DI 10.1016/j.tem.2019.11.007
PG 15
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA KE2KT
UT WOS:000508388000008
PM 31822381
DA 2025-06-11
ER

PT J
AU Huang, CS
   Kawamura, T
   Toyoda, Y
   Nakao, A
AF Huang, Chien-Sheng
   Kawamura, Tomohiro
   Toyoda, Yoshiya
   Nakao, Atsunori
TI Recent advances in hydrogen research as a therapeutic medical gas
SO FREE RADICAL RESEARCH
LA English
DT Review
DE Molecular hydrogen; radical oxygen species; antioxidant therapy
ID ISCHEMIA-REPERFUSION INJURY; REDUCING OXIDATIVE STRESS; METABOLIC
   SYNDROME; RICH SALINE; RAT MODEL; ALZHEIMERS-DISEASE;
   MOLECULAR-HYDROGEN; FREE-RADICALS; PARKINSONS-DISEASE; HEPATIC-INJURY
AB Recent basic and clinical research has revealed that hydrogen is an important physiological regulatory factor with antioxidant, anti-inflammatory and anti-apoptotic protective effects on cells and organs. Therapeutic hydrogen has been applied by different delivery methods including straightforward inhalation, drinking hydrogen dissolved in water and injection with hydrogen-saturated saline. This review summarizes currently available data regarding the protective role of hydrogen, provides an outline of recent advances in research on the use of hydrogen as a therapeutic medical gas in diverse models of disease and discusses the feasibility of hydrogen as a therapeutic strategy. It is not an overstatement to say that hydrogen's impact on therapeutic and preventive medicine could be enormous in the future.
C1 [Huang, Chien-Sheng] Taipei Vet Gen Hosp, Div Thorac Surg, Dept Surg, Taipei, Taiwan.
   [Huang, Chien-Sheng] Natl Yang Ming Univ, Sch Med, Taipei 112, Taiwan.
   [Huang, Chien-Sheng; Kawamura, Tomohiro; Toyoda, Yoshiya; Nakao, Atsunori] Univ Pittsburgh, Med Ctr, Heart Lung & Esophageal Surg Inst, Pittsburgh, PA USA.
   [Kawamura, Tomohiro; Nakao, Atsunori] Univ Pittsburgh, Med Ctr, Thomas E Starzl Transplantat Inst, Dept Surg, Pittsburgh, PA USA.
C3 Taipei Veterans General Hospital; National Yang Ming Chiao Tung
   University; Pennsylvania Commonwealth System of Higher Education
   (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of
   Higher Education (PCSHE); University of Pittsburgh
RP Nakao, A (corresponding author), El551,Biomed Sci Tower,200 Lothrop St, Pittsburgh, PA 15213 USA.
EM anakao@imap.pitt.edu
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NR 87
TC 263
Z9 286
U1 8
U2 97
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1071-5762
EI 1029-2470
J9 FREE RADICAL RES
JI Free Radic. Res.
PD SEP
PY 2010
VL 44
IS 9
BP 971
EP 982
DI 10.3109/10715762.2010.500328
PG 12
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 654RN
UT WOS:000282185800001
PM 20815764
DA 2025-06-11
ER

PT J
AU Al-Qahtani, AS
AF Al-Qahtani, Amal Saeed
TI SLEEP APNEA: A REVIEW ON THE RISK FACTORS ASSOCIATED WITH OBSTRUCTIVE
   SLEEP APNEA PATIENTS
SO INTERNATIONAL JOURNAL OF MEDICAL DENTISTRY
LA English
DT Review
DE sleep apnea; obstructive sleep apnea; diabetes; hyperlipidemia; obesity;
   hypothyroidism; edentulism
ID PREVALENCE; DIAGNOSIS; OBESITY
AB Obstructive sleep apnea (OSA) syndrome is a disorder characterized by repeated upper airway disruptive events during sleep and by daytime sleepness. Diabetes and OSA often progress in the same individuals, suggesting a common mechanisms and bidirectional relations with each other. Hyperlipidemia increased from 15.1% in subjects without OSA to 26.1% in those with severe OSA, P < 0.001. Thyroid disfunction has been shown as the cause of OSA, also indirectly affecting OSA through its association with the metabolic syndrome. Obesity is another risk factor of OSA, both conditions being related with chronic low-grade inflammation and oxidative stress. Edentulism is a common disorder among elderly people and only a few studies addressed the association between edentulism and OSAHS. This review will focus on the risk factors associated with obstructive sleep apnea patients.
C1 [Al-Qahtani, Amal Saeed] King Saud Univ, Riyadh, Saudi Arabia.
C3 King Saud University
RP Al-Qahtani, AS (corresponding author), King Saud Univ, Riyadh, Saudi Arabia.
EM amalsq.sds@gmail.com
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Z9 1
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PU APOLLONIA UNIV IASI
PI IASI
PA 2 MUZICII ST, IASI, 00000, ROMANIA
SN 2066-6063
J9 INT J MED DENT
JI Int. J. Med. Dent.
PD APR-JUN
PY 2020
VL 24
IS 2
BP 136
EP 143
PG 8
WC Dentistry, Oral Surgery & Medicine
WE Emerging Sources Citation Index (ESCI)
SC Dentistry, Oral Surgery & Medicine
GA LZ0NO
UT WOS:000540928700004
DA 2025-06-11
ER

PT J
AU Botchway, BOA
   Moore, MK
   Akinleye, FO
   Iyer, IC
   Fang, M
AF Botchway, Benson O. A.
   Moore, Masania K.
   Akinleye, Faith O.
   Iyer, Ishwari C.
   Fang, Marong
TI Nutrition: Review on the Possible Treatment for Alzheimer's Disease
SO JOURNAL OF ALZHEIMERS DISEASE
LA English
DT Review
DE Alzheimer's disease; curcumin; dementia; Mediterranean diet;
   neurodegenerative; nutrition; vitamins
ID NF-KAPPA-B; OXIDATIVE STRESS; COGNITIVE DECLINE; AMYLOID-BETA;
   VITAMIN-E; MEDITERRANEAN DIET; GINKGO-BILOBA; RETINOIC ACID; METABOLIC
   SYNDROME; HYDROGEN-PEROXIDE
AB Since its discovery some hundred years ago, Alzheimer's disease (AD), a neurodegenerative disease and an eminent cause of most dementia, continues to pose problems for affected families and society, especially in developed countries. With the approved medications by the Food and Drugs Administration in the United States, effectual treatment of AD apropos to the complete eradication of the disease continues to be elusive due to complexities relating to the pathophysiology of the disease. Nutrition has and continues to play a salient role in the survival of living organisms with no exception for human beings. Herein, we report the connection between nutrition and AD with particular attention to vitamins, curcumin, and the Mediterranean diet.
C1 [Botchway, Benson O. A.; Fang, Marong] Zhejiang Univ, Sch Med, Inst Neurosci, 866 Yuhangtang Rd, Hangzhou 310058, Zhejiang, Peoples R China.
   [Botchway, Benson O. A.; Moore, Masania K.; Akinleye, Faith O.; Iyer, Ishwari C.] Zhejiang Univ, Sch Basic Med Sci, Hangzhou, Zhejiang, Peoples R China.
C3 Zhejiang University; Zhejiang University
RP Fang, M (corresponding author), Zhejiang Univ, Sch Med, Inst Neurosci, 866 Yuhangtang Rd, Hangzhou 310058, Zhejiang, Peoples R China.
EM fangmaro@zju.edu.cn
RI Botchway, Benson/ABD-3436-2021
OI Botchway, Benson/0000-0001-9732-7904
FU National Natural Science Foundation of China [81671138]
FX We are grateful to the National Natural Science Foundation of China,
   grant number 81671138, for funding this project. Additionally, we wish
   to acknowledge Ms. Wasan Adel Abdulshaheed Ebrahim Ali Al-Ghasra for
   producing the images used in this report.
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NR 154
TC 23
Z9 24
U1 1
U2 70
PU IOS PRESS
PI AMSTERDAM
PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS
SN 1387-2877
EI 1875-8908
J9 J ALZHEIMERS DIS
JI J. Alzheimers Dis.
PY 2018
VL 61
IS 3
BP 867
EP 883
DI 10.3233/JAD-170874
PG 17
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA FT0VD
UT WOS:000422845200003
PM 29254101
DA 2025-06-11
ER

PT J
AU Papanas, N
   Ziegler, D
AF Papanas, N.
   Ziegler, D.
TI Polyneuropathy in Impaired Glucose Tolerance: Is Postprandial
   Hyperglycemia the Main Culprit? A Mini-Review
SO GERONTOLOGY
LA English
DT Review
DE Diabetes mellitus; Hyperglycemia; Impaired glucose tolerance; Peripheral
   neuropathy
ID AUGSBURG SURVEYS S2; DIABETIC POLYNEUROPATHY; METHYLGLYOXAL; NEUROPATHY
AB There is accumulating evidence for the mutual relationship between peripheral neuropathy and impaired glucose tolerance (IGT). The key factor in the pathogenesis of neuropathy in IGT is postprandial hyperglycemia, which induces increased oxidative stress, endothelial dysfunction, and activation of both protein kinase C and the polyol pathway, leading to impaired neuronal metabolism and DNA damage. Other pathogenic factors include dyslipidemia and the metabolic syndrome. The cornerstone of management is improved glycemic control, although a long sustainable effect has not been documented yet, calling for further supportive trials. Secondary therapeutic targets encompass hypolipidemic and antihypertensive treatment, smoking cessation and weight loss. The increasing awareness of peripheral neuropathy in IGT is expected to improve healthcare provision in subjects with this condition. Copyright (C) 2012 S. Karger AG, Basel
C1 [Ziegler, D.] Univ Dusseldorf, Leibniz Ctr Diabet Res, German Diabet Ctr, Inst Clin Diabetol, DE-40225 Dusseldorf, Germany.
   Univ Hosp, Dept Metab Dis, Dusseldorf, Germany.
C3 Leibniz Association; Deutsches Diabetes-Zentrum (DDZ); Heinrich Heine
   University Dusseldorf
RP Ziegler, D (corresponding author), Univ Dusseldorf, Leibniz Ctr Diabet Res, German Diabet Ctr, Inst Clin Diabetol, Aufm Hennekamp 65, DE-40225 Dusseldorf, Germany.
EM dan.ziegler@ddz.uni-dueaseldorf.de
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NR 22
TC 19
Z9 20
U1 0
U2 1
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0304-324X
EI 1423-0003
J9 GERONTOLOGY
JI Gerontology
PY 2013
VL 59
IS 3
BP 193
EP 198
DI 10.1159/000343988
PG 6
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA 133LP
UT WOS:000318140200001
PM 23207896
OA Bronze
DA 2025-06-11
ER

PT J
AU Harno, E
   White, A
AF Harno, Erika
   White, Anne
TI Will treating diabetes with 11β-HSD1 inhibitors affect the HPA axis?
SO TRENDS IN ENDOCRINOLOGY AND METABOLISM
LA English
DT Review
ID 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1; SPLANCHNIC CORTISOL
   PRODUCTION; PITUITARY-ADRENAL AXIS; DIET-INDUCED OBESITY; METABOLIC
   SYNDROME; ADIPOSE-TISSUE; VISCERAL OBESITY; MICE; LIVER; MELLITUS
AB Inhibitors of 11 beta-HSD1 are in clinical trials for the treatment of type 2 diabetes. These compounds act by decreasing the cortisol generated in liver and adipose tissue, and therefore reducing tissue-specific gluconeogenesis and fatty acid metabolism. However, there is concern that reduction in tissue-regenerated cortisol might decrease feedback to the hypothalamic-pituitary-adrenal (HPA) axis, resulting in upregulation of cortisol from the adrenal gland. This review considers evidence from 11 beta-HSD1 knockout and transgenic mice, inhibitor studies and results from clinical trials evaluating HPA axis biomarkers. It is clear that analysis of the HPA axis is not sufficiently detailed, and there is a need to understand the subtle changes in the axis associated with pulsatility, diurnal rhythm and stress.
C1 [White, Anne] Univ Manchester, Acad Hlth Sci Ctr, Fac Life Sci, Manchester M13 9PL, Lancs, England.
   Univ Manchester, Acad Hlth Sci Ctr, Fac Med & Human Sci, Manchester M13 9PL, Lancs, England.
C3 University of Manchester; University of Manchester
RP White, A (corresponding author), Univ Manchester, Acad Hlth Sci Ctr, Fac Life Sci, Manchester M13 9PL, Lancs, England.
EM anne.white@manchester.ac.uk
RI Harno, Erika/AAJ-3644-2020; White, Anne/G-7717-2015
OI White, Anne/0000-0002-7686-2884; Harno, Erika/0000-0002-1304-6775
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NR 57
TC 27
Z9 38
U1 0
U2 0
PU ELSEVIER SCIENCE LONDON
PI LONDON
PA 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND
SN 1043-2760
EI 1879-3061
J9 TRENDS ENDOCRIN MET
JI Trends Endocrinol. Metab.
PD OCT
PY 2010
VL 21
IS 10
BP 619
EP 627
DI 10.1016/j.tem.2010.06.004
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 676KO
UT WOS:000283910100005
PM 20594868
DA 2025-06-11
ER

PT J
AU Imai, J
   Katagiri, H
   Yamada, T
   Ishigaki, Y
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   Uno, K
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AF Imai, Junta
   Katagiri, Hideki
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   Ishihara, Hisamitsu
   Niijima, Akira
   Nakazato, Masamitsu
   Asano, Tomoichiro
   Minokoshi, Yasuhiko
   Oka, Yoshitomo
TI Regulation of Pancreatic β Cell Mass by Neuronal Signals from the Liver
SO SCIENCE
LA English
DT Article
ID ENDOPLASMIC-RETICULUM STRESS; GLUCOSE-HOMEOSTASIS; METABOLIC SYNDROME;
   INSULIN; GENE; PROLIFERATION; SENSITIVITY; DYSFUNCTION; DISRUPTION;
   OBESITY
AB Metabolic regulation in mammals requires communication between multiple organs and tissues. The rise in the incidence of obesity and associated metabolic disorders, including type 2 diabetes, has renewed interest in interorgan communication. We used mouse models to explore the mechanism whereby obesity enhances pancreatic beta cell mass, pathophysiological compensation for insulin resistance. We found that hepatic activation of extracellular regulated kinase (ERK) signaling induced pancreatic b cell proliferation through a neuronal- mediated relay of metabolic signals. This metabolic relay from the liver to the pancreas is involved in obesity- induced islet expansion. In mouse models of insulin- deficient diabetes, liver- selective activation of ERK signaling increased b cell mass and normalized serum glucose levels. Thus, interorgan metabolic relay systems may serve as valuable targets in regenerative treatments for diabetes.
C1 [Katagiri, Hideki; Suzuki, Toshinobu; Kudo, Hirohito; Uno, Kenji; Gao, Junhong; Kaneko, Keizo] Tohoku Univ, Grad Sch Med, Div Adv Therapeut Metab Dis, Ctr Translat & Adv Anim Res, Sendai, Miyagi 9808575, Japan.
   [Imai, Junta; Yamada, Tetsuya; Ishigaki, Yasushi; Suzuki, Toshinobu; Kudo, Hirohito; Hasegawa, Yutaka; Kaneko, Keizo; Ishihara, Hisamitsu; Oka, Yoshitomo] Tohoku Univ, Grad Sch Med, Div Mol Metab & Diabet, Sendai, Miyagi 9808575, Japan.
   [Niijima, Akira] Niigata Univ, Sch Med, Niigata 9518150, Japan.
   [Nakazato, Masamitsu] Miyazaki Univ, Miyazaki Med Coll, Dept Internal Med 3, Miyazaki 8891692, Japan.
   [Asano, Tomoichiro] Hiroshima Univ, Grad Sch Med, Dept Med Sci, Hiroshima, Japan.
   [Minokoshi, Yasuhiko] Natl Inst Physiol Sci, Div Endocrinol & Metab, Dept Dev Physiol, Okazaki, Aichi 444, Japan.
C3 Tohoku University; Tohoku University; Niigata University; University of
   Miyazaki; Hiroshima University; National Institutes of Natural Sciences
   (NINS) - Japan; National Institute for Physiological Sciences (NIPS)
RP Katagiri, H (corresponding author), Tohoku Univ, Grad Sch Med, Div Adv Therapeut Metab Dis, Ctr Translat & Adv Anim Res, Sendai, Miyagi 9808575, Japan.
EM katagiri@mail.tains.tohoku.ac.jp
RI Imai, Junta/NFG-4543-2025
OI Minokoshi, Yasuhiko/0000-0002-7119-4805
FU 21st Center of Excellence (COE); Global-COE; Ministry of Education,
   Culture, Sports, Science and Technology of Japan; Ministry of Health,
   Labor and Welfare of Japan
FX We thank M. Yokoyama for the generous gift of recombinant adenoviruses.
   This work was supported by Grants-in Aid (H.K., Y.O., and J.I.); the
   21st Center of Excellence (COE) (H.K.) and Global-COE (Y.O.) programs
   from the Ministry of Education, Culture, Sports, Science and Technology
   of Japan; and a Grant-in Aid (Y.O.) from the Ministry of Health, Labor
   and Welfare of Japan. Tohoku University, J.I., H.K., and Y.O have
   applied for patents related to this work in the United States and Japan.
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NR 24
TC 186
Z9 205
U1 0
U2 18
PU AMER ASSOC ADVANCEMENT SCIENCE
PI WASHINGTON
PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA
SN 0036-8075
EI 1095-9203
J9 SCIENCE
JI Science
PD NOV 21
PY 2008
VL 322
IS 5905
BP 1250
EP 1254
DI 10.1126/science.1163971
PG 5
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 374HC
UT WOS:000261033400043
PM 19023081
DA 2025-06-11
ER

PT J
AU Dabravolski, SA
   Sukhorukov, VN
   Melnichenko, AA
   Khotina, VA
   Orekhov, AN
AF Dabravolski, Siarhei A.
   Sukhorukov, Vasily N.
   Melnichenko, Alexandra A.
   Khotina, Victoria A.
   Orekhov, Alexander N.
TI Potential Application of the Plant-Derived Essential Oils for
   Atherosclerosis Treatment: Molecular Mechanisms and Therapeutic
   Potential
SO MOLECULES
LA English
DT Review
DE essential oils; atherosclerosis; inflammation; oxidative stress;
   endothelial dysfunction
ID CARDIOVASCULAR-DISEASES; CONTAINING MOUTHWASH; IN-VITRO; INJURY;
   CONSTITUENTS; GINGIVITIS; MICE; RISK
AB Essential oils (EOs) are complex secondary metabolites identified in many plant species. Plant-derived EOs have been widely used in traditional medicine for centuries for their health-beneficial effects. Some EOs and their active ingredients have been reported to improve the cardiovascular system, in particular to provide an anti-atherosclerotic effect. The objective of this review is to highlight the recent research investigating the anti-inflammatory, anti-oxidative and lipid-lowering properties of plant-derived EOs and discuss their mechanisms of action. Also, recent clinical trials exploring anti-inflammatory and anti-oxidative activities of EOs are discussed. Future research on EOs has the potential to identify new bioactive compounds and invent new effective agents for treatment of atherosclerosis and related diseases such as diabetes, metabolic syndrome and obesity.
C1 [Dabravolski, Siarhei A.] Braude Acad Coll Engn, Dept Biotechnol Engn, POB 78,Snunit 51, IL-2161002 Karmiel, Israel.
   [Sukhorukov, Vasily N.; Melnichenko, Alexandra A.; Khotina, Victoria A.; Orekhov, Alexander N.] Inst Gen Pathol & Pathophysiol, 8 Baltiyskaya St, Moscow 125315, Russia.
C3 Braude Academic College of Engineering; Russian Academy of Medical
   Sciences; Institute of General Pathology & Pathophysiology, RAMS
RP Dabravolski, SA (corresponding author), Braude Acad Coll Engn, Dept Biotechnol Engn, POB 78,Snunit 51, IL-2161002 Karmiel, Israel.
EM sergedobrowolski@gmail.com; vnsukhorukov@gmail.com;
   sasha.melnichenko@gmail.com; nafany905@gmail.com; a.h.opexob@gmail.com
RI Khotina, Viktoria/AAD-5232-2019; Melnichenko, Alexandra/V-5783-2018;
   Dabravolski, Siarhei/E-8303-2015; Sukhorukov, Vasily/H-6545-2016
OI Orekhov, Alexander/0000-0002-3318-4681; Dabravolski,
   Siarhei/0000-0002-0547-6310; Khotina, Victoria/0000-0003-2096-3237;
   Sukhorukov, Vasily/0000-0002-0312-3773
FU Ministry of Science and Higher Education of the Russian Federation
   [FGFU-2022-00008]
FX The work was supported by the Ministry of Science and Higher Education
   of the Russian Federation (Project # FGFU-2022-00008).
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NR 103
TC 3
Z9 3
U1 3
U2 17
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 1420-3049
J9 MOLECULES
JI Molecules
PD AUG
PY 2023
VL 28
IS 15
AR 5673
DI 10.3390/molecules28155673
PG 20
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA O7NK4
UT WOS:001045631600001
PM 37570643
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Odegaard, JI
   Chawla, A
AF Odegaard, Justin I.
   Chawla, Ajay
TI Connecting Type 1 and Type 2 Diabetes through Innate Immunity
SO COLD SPRING HARBOR PERSPECTIVES IN MEDICINE
LA English
DT Article
ID TUMOR-NECROSIS-FACTOR; STIMULATED INSULIN-SECRETION;
   ENDOPLASMIC-RETICULUM STRESS; OBESITY-INDUCED INFLAMMATION;
   ISLET-ASSOCIATED MACROPHAGES; ACCELERATOR HYPOTHESIS; ADIPOSE-TISSUE;
   ALTERNATIVE ACTIVATION; METABOLIC SYNDROME; WEIGHT-GAIN
AB The escalating epidemic of obesity has driven the prevalence of both type 1 and 2 diabetes mellitus to historically high levels. Chronic low-grade inflammation, which is present in both type 1 and type 2 diabetics, contributes to the pathogenesis of insulin resistance. The accumulation of activated innate immune cells in metabolic tissues results in release of inflammatory mediators, in particular, IL-1 beta and TNF alpha, which promote systemic insulin resistance and beta-cell damage. In this article, we discuss the central role of innate immunity and, in particular, the macrophage in insulin sensitivity and resistance, beta-cell damage, and autoimmune insulitis. We conclude with a discussion of the therapeutic implications of this integrated understanding of diabetic pathology.
C1 [Odegaard, Justin I.] Stanford Univ, Dept Pathol, Sch Med, Stanford, CA 94305 USA.
   [Chawla, Ajay] Univ Calif San Francisco, Cardiovasc Res Inst, Dept Physiol, San Francisco, CA 94158 USA.
   [Chawla, Ajay] Univ Calif San Francisco, Dept Med, San Francisco, CA 94158 USA.
C3 Stanford University; University of California System; University of
   California San Francisco; University of California System; University of
   California San Francisco
RP Chawla, A (corresponding author), Univ Calif San Francisco, Cardiovasc Res Inst, Dept Physiol, San Francisco, CA 94158 USA.
EM ajay.chawla@ucsf.edu
FU NIH [DK076760, HL076746, DP1OD006415]; Larry L. Hillblom Foundation
   Network Grant; Diabetes Family Fund (UCSF)
FX Our work is supported by grants from the NIH (DK076760, HL076746), Larry
   L. Hillblom Foundation Network Grant, Diabetes Family Fund (UCSF), and
   an NIH Director's Pioneer Award (DP1OD006415) to A. C. Because of space
   limitations, we regret that we are unable to cite all relevant
   publications on this topic from our colleagues.
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NR 127
TC 126
Z9 149
U1 0
U2 11
PU COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
PI COLD SPRING HARBOR
PA 1 BUNGTOWN RD, COLD SPRING HARBOR, NY 11724 USA
SN 2157-1422
J9 CSH PERSPECT MED
JI Cold Spring Harb. Perspect. Med.
PD MAR
PY 2012
VL 2
IS 3
AR a007724
DI 10.1101/cshperspect.a007724
PG 18
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 080WL
UT WOS:000314274700001
PM 22393536
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Comar, KM
   Sterling, RK
AF Comar, KM
   Sterling, RK
TI Review article: drug therapy for non-alcoholic fatty liver disease
SO ALIMENTARY PHARMACOLOGY & THERAPEUTICS
LA English
DT Article
ID NECROSIS-FACTOR-ALPHA; NATURAL-HISTORY; VITAMIN-E; URSODEOXYCHOLIC ACID;
   IN-VIVO; STEATOHEPATITIS; METFORMIN; INSULIN; PENTOXIFYLLINE;
   ROSIGLITAZONE
AB Non-alcoholic fatty liver disease represents a spectrum of liver diseases, characterized mainly by macrovesicular steatosis in the absence of significant alcohol ingestion. Non-alcoholic fatty liver disease includes both non-alcoholic fatty liver and non-alcoholic steatohepatitis.
   Non-alcoholic steatohepatitis once considered a benign process is now known to lead to progressive fibrosis and cirrhosis. Histologically indistinguishable from alcoholic liver disease, the exact aetiology of non-alcoholic fatty liver disease remains unknown, but the fundamental pathophysiological process appears to be insulin resistance and oxidative stress related to the metabolic syndrome.
   Therapy has focused on risk factors, weight reduction and pharmacological intervention. Promising pharmacological treatments have been demonstrated with antioxidants, insulin sensitizers, hepatoprotectants and lipid-lowering agents. However, without larger randomized studies, no pharmacological treatments can be recommended at this time.
C1 Virginia Commonwealth Univ, Sect Hepatol, Dept Internal Med, Div Gastroenterol Hepatol & Nutr, Richmond, VA 23298 USA.
C3 Virginia Commonwealth University
RP Virginia Commonwealth Univ, Sect Hepatol, Dept Internal Med, Div Gastroenterol Hepatol & Nutr, MCV Box 980341, Richmond, VA 23298 USA.
EM rksterli@hsc.vcu.edu
RI Sterling, Richard/AAV-1598-2020
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NR 66
TC 50
Z9 62
U1 0
U2 9
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0269-2813
EI 1365-2036
J9 ALIMENT PHARM THER
JI Aliment. Pharmacol. Ther.
PD JAN 15
PY 2006
VL 23
IS 2
BP 207
EP 215
DI 10.1111/j.1365-2036.2006.02751.x
PG 9
WC Gastroenterology & Hepatology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Pharmacology & Pharmacy
GA 996GC
UT WOS:000234161400001
PM 16393299
DA 2025-06-11
ER

PT J
AU de Rossi, LS
   Nakama, RP
   Dos Santos, LF
   Berto-Pereira, L
   Malvezi, AD
   Lovo-Martins, MI
   Cardoso, APC
   Tozoni, LC
   Jussiani, EI
   de Freitas, AMD
   Martins-Pinge, MC
   Pinge, P
AF de Rossi, Lucas Sobral
   Nakama, Raquel Pires
   Dos Santos, Lucas Felipe
   Berto-Pereira, Leonardo
   Malvezi, Aparecida Donizette
   Lovo-Martins, Maria Isabel
   Cardoso, Ana Paula Canizares
   Tozoni-Filho, Luiz Claudio
   Jussiani, Eduardo Inocente
   de Freitas, Andressa Mendes Dionisio
   Martins-Pinge, Marli Cardoso
   Pinge-Filho, Phileno
TI Metabolic syndrome promotes resistance to aspirin in mitigating bone
   loss in murine periodontal disease
SO LIFE SCIENCES
LA English
DT Article
DE Periodontitis; Ligature model; Obesity; Bone loss; Nitric oxide
ID NITRIC-OXIDE SYNTHASE; OXIDATIVE STRESS; TNF-ALPHA; OSTEOCLAST ACTIVITY;
   RAT MODEL; OBESITY; TISSUE; PATHOGENESIS; INFLAMMATION; ASSOCIATION
AB Aims: This study aimed to investigate the protective effects of aspirin (ASA) on alveolar bone loss in a mouse model with metabolic syndrome (MetS) and concurrent periodontal disease (PD). Specifically, the study sought to determine whether ASA could mitigate bone loss in MetS and non-MetS animals with PD and explore the correlation between gingival nitric oxide (NO) levels and bone resorption. Main methods: Newborn female Swiss mice were administered monosodium glutamate (MSG) (4 mg/g) during the initial 5 days of life to induce MetS (MetS group), while the control group (SAL) was administered saline. On the 60th day, PD was induced in both groups. Half of the animals were treated daily with ASA (40 mg/kg). MetS was characterized by the Lee index, blood glucose, and cardiovascular parameters. Maxillae were evaluated by microtomography and histopathology, showing significant bone loss after PD induction. Key findings: Animals with MetS exhibited higher alveolar bone loss than controls. SAL animals treated with ASA had less bone loss than their MetS counterparts. Gingival NO levels were elevated in animals with PD, and a strong correlation was found between NO levels and bone resorption. ASA reduced NO in non-MetS animals, but MetS animals were resistant to this effect. Significance: These findings suggest a protective mechanism of ASA against bone loss in non-MetS animals with PD, an effect that was not observed in MetS animals. Consequently, this study provides novel insights into the intricate relationship between MetS and PD in mice.
C1 [de Rossi, Lucas Sobral; Nakama, Raquel Pires; Berto-Pereira, Leonardo; Malvezi, Aparecida Donizette; Lovo-Martins, Maria Isabel; Cardoso, Ana Paula Canizares; Tozoni-Filho, Luiz Claudio; Pinge-Filho, Phileno] Univ Estadual Londrina, Dept Immunol Parasitol & Gen Pathol, Londrina, Parana, Brazil.
   [Dos Santos, Lucas Felipe; Pinge-Filho, Phileno] Univ Estadual Londrina, Dept Microbiol, Londrina, Parana, Brazil.
   [Jussiani, Eduardo Inocente] Univ Estadual Londrina, Dept Phys, Londrina, Parana, Brazil.
   [de Freitas, Andressa Mendes Dionisio; Martins-Pinge, Marli Cardoso] Univ Estadual Londrina, Dept Physiol Sci, Londrina, Parana, Brazil.
C3 Universidade Estadual de Londrina; Universidade Estadual de Londrina;
   Universidade Estadual de Londrina; Universidade Estadual de Londrina
RP Pinge, P (corresponding author), Dept Immunol Parasitol & Gen Pathol, Lab Expt Immunopathol, Celso Garcia Cid Highway 445,Km 380, Londrina, Parana, Brazil.
EM pingefilho@uel.br
RI Pinge-Filho, Phileno/G-2844-2012; Cardoso, Ana/A-9191-2018; Jussiani,
   Eduardo/AAG-8306-2020; Pinge, Marli/C-4417-2014; Freitas,
   Andressa/B-7264-2012
OI Inocente Jussiani, Eduardo/0000-0002-8500-5710; Freitas,
   Andressa/0000-0001-8453-7742
FU Conselho Nacional de Desenvolvimento Cientifico e Tecnologico
   [30411/2022-7, 404420/2023-0]; Secretaria de Estado da Ciencia,
   Tecnologia, e Ensino Superior do Parana [4560.19.571.06.6153]
FX This work was supported by Conselho Nacional de Desenvolvimento
   Cientifico e Tecnologico (No. 30411/2022-7 and 404420/2023-0) and
   Secretaria de Estado da Ciencia, Tecnologia, e Ensino Superior do Parana
   (grant number 4560.19.571.06.6153) .
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NR 69
TC 0
Z9 1
U1 1
U2 1
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0024-3205
EI 1879-0631
J9 LIFE SCI
JI Life Sci.
PD DEC 15
PY 2024
VL 359
AR 123224
DI 10.1016/j.lfs.2024.123224
EA NOV 2024
PG 10
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA M2Q0K
UT WOS:001356024800001
PM 39515415
DA 2025-06-11
ER

PT J
AU Lee, HJ
   Lee, J
   Yoon, C
   Park, Y
   Joo, YH
   Park, JO
   Seo, YJ
   Park, KH
AF Lee, Hyun Jin
   Lee, Juhyung
   Yoon, Chulyoung
   Park, Yesai
   Joo, Young-Hoon
   Park, Jun-Ook
   Seo, Young Joon
   Park, Kyoung Ho
TI Association of dietary factors with noise-induced hearing loss in Korean
   population: A 3-year national cohort study
SO PLOS ONE
LA English
DT Article
ID NUTRITION EXAMINATION SURVEY; OCCUPATIONAL NOISE; RISK-FACTORS;
   ALCOHOL-CONSUMPTION; METABOLIC SYNDROME; OXIDATIVE STRESS; GLOBAL
   BURDEN; FREE-RADICALS; IMPAIRMENT; SMOKING
AB Noise-induced hearing loss (NIHL) is a hearing impairment (HI) caused by various clinical factors. Identifying the relationship between NIHL and nutrient consumption could help in reducing the prevalence of hearing loss. The aim of this study was to analyze the relationship between NIHL and dietary factors using data of the Korea National Health and Nutrition Examination survey (KNHANES). The data were collected from The Fifth KNHANES 2010-2012. The survey was taken by a total of 10,850 participants aged 20-65 years. Air conduction audiometry was measured at 500, 1000, 2000, and 4000 Hz in both ears. Metabolic syndrome, noise exposure, alcohol consumption, smoking, income level, marital status, and nutritional intake were evaluated. The differences between non-HI and HI participants in the noise-exposed group showed statistically significant differences in age, sex, marital and smoking status, alcohol consumption, and fasting glucose and triglyceride levels (p<0.05). In a multiple regression analysis of the noise-exposed group, age showed a significant association with HI (OR: 0.604; 95% CI: 0.538-0.678) after adjusting for confounders. In multivariate analysis for dietary factors affecting HI in noise-exposed groups, retinol (OR: 1.356; 95% CI: 1.068-1.722), niacin (OR: 1.5; 95% CI: 1.022-2.201), and carbohydrates (OR: 0.692; 95% CI: 0.486-0.985) showed a significant association with NIHL. Age was identified as the only factor significantly affecting NIHL. When the dietary factors of the noise-exposed group were analyzed, high intake of niacin and retinol and low intake of carbohydrates appeared to reduce the risk of hearing loss.
C1 [Lee, Hyun Jin; Park, Yesai] Catholic Univ Korea, Coll Med, Incheon St Marys Hosp, Dept Otorhinolaryngol Head & Neck Surg, Seoul, South Korea.
   [Lee, Juhyung; Yoon, Chulyoung] Yonsei Univ, Dept Biostat, Wonju Coll Med, Wonju, South Korea.
   [Joo, Young-Hoon; Park, Kyoung Ho] Catholic Univ Korea, Coll Med, Dept Otolaryngol Head & Neck Surg, Seoul, South Korea.
   [Park, Jun-Ook] Catholic Univ Korea, Coll Med, Dept Otolaryngol Head & Neck Surg, Eunpyeong St Marys Hosp, Seoul, South Korea.
   [Seo, Young Joon] Yonsei Univ, Dept Otorhinolaryngol, Wonju Coll Med, Wonju, South Korea.
C3 Catholic University of Korea; Yonsei University; Catholic University of
   Korea; Catholic University of Korea; Yonsei University
RP Park, KH (corresponding author), Catholic Univ Korea, Coll Med, Dept Otolaryngol Head & Neck Surg, Seoul, South Korea.
EM khpent@catholic.ac.kr
RI Seo, Young Joon/JHS-6247-2023; Joo, Young Hoon/AAU-7285-2020
OI Park, Yesai/0000-0003-1707-1297; Seo, Young Joon/0000-0002-2839-4676;
   YOON, Chul Young/0000-0003-0162-1741; Joo, Young
   Hoon/0000-0002-4662-1916
FU National Research Foundation (NRF) of Korea [2020R1C1C1005965]
FX National Research Foundation (NRF) of Korea grant 2020R1C1C1005965. The
   funders had no role in study design, data collection and analysis,
   decision to publish, or preparation of the manuscript.
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NR 53
TC 6
Z9 6
U1 0
U2 3
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD DEC 30
PY 2022
VL 17
IS 12
AR e0279884
DI 10.1371/journal.pone.0279884
PG 13
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 8O4NX
UT WOS:000925813500184
PM 36584228
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Shen, HH
   Alex, R
   Bellner, L
   Raffaele, M
   Licari, M
   Vanella, L
   Stec, DE
   Abraham, NG
AF Shen, Hsin-Hsueh
   Alex, Ragin
   Bellner, Lars
   Raffaele, Marco
   Licari, Maria
   Vanella, Luca
   Stec, David E.
   Abraham, Nader G.
TI Milk thistle seed cold press oil attenuates markers of the metabolic
   syndrome in a mouse model of dietary-induced obesity
SO JOURNAL OF FOOD BIOCHEMISTRY
LA English
DT Article
DE heme oxygenase; metabolism; mitochondria; type II diabetes
ID GLUCOSE DEPRIVATION; INSULIN-RESISTANCE; HEPATIC STEATOSIS;
   ARTERIAL-PRESSURE; OXIDATIVE STRESS; SILYMARIN; INFLAMMATION;
   CONTRIBUTES; ACTIVATION; INDUCTION
AB Milk thistle cold press oil (MTO) is an herbal remedy derived fromSilybum marianumwhich contains a low level of silymarin and mixture of polyphenols and flavonoids. The effect of MTO on the cardiovascular and metabolic complications of obesity was studied in mice that were fed a high-fat diet (HFD) for 20 weeks and treated with MTO for the final 8 weeks of the diet. MTO treatment attenuated HFD-induced obesity, fasting hyperglycemia, hypertension, and induced markers of mitochondrial fusion and browning of white adipose. Markers of inflammation were also attenuated in both adipose and the liver of MTO-treated mice. In addition, MTO resulted in the improvement of liver fibrosis. These results demonstrate that MTO has beneficial actions to attenuate dietary obesity-induced weight gain, hyperglycemia, hypertension, inflammation, and suggest that MTO supplementation may prove beneficial to patients exhibiting symptoms of metabolic syndrome. Practical applications Natural supplements are increasingly being considered as potential therapies for many chronic cardiovascular and metabolic diseases. Milk thistle cold press oil (MTO) is derived fromSilybum marianumwhich is used as a dietary supplement in different parts of the world. The results of the present study demonstrate that MTO supplementation normalizes several metabolic and cardiovascular complications arising from dietary-induced obesity. MTO supplementation also had anti-inflammatory actions in the adipose as well as the liver. These results suggest that supplementation of MTO into the diet of obese individuals may afford protection against the worsening of cardiovascular and metabolic disease and improve inflammation and liver fibrosis.
C1 [Shen, Hsin-Hsueh; Raffaele, Marco; Licari, Maria; Abraham, Nader G.] New York Med Coll, Dept Med, Valhalla, NY 10595 USA.
   [Shen, Hsin-Hsueh] Natl Def Med Ctr, Dept & Inst Pharmacol, Taipei, Taiwan.
   [Alex, Ragin; Bellner, Lars; Abraham, Nader G.] New York Med Coll, Dept Pharmacol, Valhalla, NY 10595 USA.
   [Raffaele, Marco; Licari, Maria; Vanella, Luca] Univ Catania, Dept Drug Sci, Catania, Italy.
   [Stec, David E.] Univ Mississippi, Med Ctr, Dept Physiol & Biophys, Cardiorenal & Metab Dis Res Ctr, 2500 North State St, Jackson, MS 39216 USA.
C3 New York Medical College; National Defense Medical Center; New York
   Medical College; University of Catania; University of Mississippi
   Medical Center; University of Mississippi
RP Stec, DE (corresponding author), Univ Mississippi, Med Ctr, Dept Physiol & Biophys, Cardiorenal & Metab Dis Res Ctr, 2500 North State St, Jackson, MS 39216 USA.; Abraham, NG (corresponding author), New York Med Coll, Dept Med & Pharmacol, Valhalla, NY 10595 USA.
EM dstec@umc.edu; nader_abraham@nymc.edu
RI Raffaele, Marco/AAQ-2895-2020; Vanella, Luca/J-7354-2016
FU National Institutes of Health [56-139561, DK121748-01A1, HL05197-11];
   National Institute of General Medical Sciences [P20GM104357-02]
FX National Institutes of Health, Grant/Award Number: 56-139561,
   DK121748-01A1 and HL05197-11; National Institute of General Medical
   Sciences, Grant/Award Number: P20GM104357-02
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NR 57
TC 15
Z9 15
U1 0
U2 8
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0145-8884
EI 1745-4514
J9 J FOOD BIOCHEM
JI J. Food Biochem.
PD DEC
PY 2020
VL 44
IS 12
AR e13522
DI 10.1111/jfbc.13522
EA OCT 2020
PG 11
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA PM2UE
UT WOS:000576734800001
PM 33047319
OA gold, Green Accepted
DA 2025-06-11
ER

PT J
AU Tkachenko, O
   Polishchuk, I
   Gorchakova, N
   Zaychenko, H
AF Tkachenko, Oksana
   Polishchuk, Iryna
   Gorchakova, Nadiya
   Zaychenko, Hanna
TI Metabolic Syndrome and Lipid Metabolism Disorders: Molecular and
   Biochemical Aspects
SO ACTA FACULTATIS MEDICAE NAISSENSIS
LA English
DT Review
DE adipose tissue; obesity; diabetes mellitus type 2; insulin resistance;
   fatty acids; endocannabinoid substances
ID INSULIN-RESISTANCE; DYSLIPIDEMIA; INFLAMMATION; OBESITY
AB The review highlights the characteristics of adipose tissue as a metabolically active organ, reveals endocrinous functions of adipose tissue and the role of adipose tissue in immune system's functioning. The role of obesity in the development of insulin resistance (IR) and diabetes mellitus type 2 and the effect of dyslipidemia on the development of metabolic syndrome (MS) and IR are given. It is shown that the main function of fatty tissue is energy storage via the maintenance of balance between lipolysis and lipogenesis processes. Inhibition of lipogenesis and enhancement of lipolysis are observed in metabolic disorders, in particular, IR. Adipose tissue's function is regulated by adipokines excreted by it. Inflammation condition is an essential constituent and one of the reasons of IR status. Neutralization of the main inflammatory cytokines does not restore sensitivity to insulin, which is indicative of the fact that inflammation condition is not the only cause of IR. Chronic low-grade inflammation develops as a result of obesity. Pro-inflammatory cytokines affect insulin signaling via stimulation of stress kinases. Functions of signal and immune cells are dependent on phospholipid composition. Unsaturated fatty acids are the substrate for synthesis of bioactive mediators. Allocated peroxisome proliferator-activated receptors (PPARs) are considered to be the main therapeutic target. Synthetic ligands of thiazolidinidones and components of the endogenous cannabinoid system of N-acetylethanolamines, capable of interacting and binding to PPARs receptors, are investigated. N-stearoylethanolamine is of special interest; its positive effect on normalization of lipid profile of different tissues, particularly insulin-sensitive tissues, has already been shown.
C1 [Tkachenko, Oksana] Palladin Inst Biochem, Kiev, Ukraine.
   [Polishchuk, Iryna] Igor Sikorsky Kyiv Polytech Inst, Kiev, Ukraine.
   [Gorchakova, Nadiya; Zaychenko, Hanna] Bogomolets Natl Med Univ, Kiev, Ukraine.
C3 National Academy of Sciences Ukraine; Palladin Institute of Biochemistry
   of NASU; Ministry of Education & Science of Ukraine; Igor Sikorsky Kyiv
   Polytechnic Institute; Bogomolets National Medical University
RP Polishchuk, I (corresponding author), Igor Sikorsky Kyiv Polytech Inst, Kiev, Ukraine.
EM tmb@kpi.ua
RI Zaychenko, Ganna/AAC-1941-2019; Polishchuk, Iryna/KXR-7012-2024
OI Tkachenko, Oksana/0000-0001-5968-2024; Ganna,
   Zaychenko/0000-0002-3506-4800
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NR 43
TC 4
Z9 4
U1 0
U2 6
PU UNIV NIS, FAC MEDICINE
PI NIS
PA BULEVAR DR ZORANA DINDICA 81, NIS, NISAVA, SERBIA
SN 0351-6083
EI 2217-2521
J9 ACTA FAC MEDICAE NAI
JI Acta Fac. Medicae Naiss.
PY 2020
VL 37
IS 1
BP 5
EP 22
DI 10.5937/afmnai2001005T
PG 18
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA NN3HE
UT WOS:000568681500001
OA gold
DA 2025-06-11
ER

PT J
AU Akbari, M
   Ostadmohammadi, V
   Tabrizi, R
   Mobini, M
   Lankarani, KB
   Moosazadeh, M
   Heydari, ST
   Chamani, M
   Kolandooz, F
   Asemi, Z
AF Akbari, Maryam
   Ostadmohammadi, Vahidreza
   Tabrizi, Reza
   Mobini, Moein
   Lankarani, Kamran B.
   Moosazadeh, Mahmood
   Heydari, Seyed Taghi
   Chamani, Maryam
   Kolandooz, Fariba
   Asemi, Zatollah
TI The effects of alpha-lipoic acid supplementation on inflammatory markers
   among patients with metabolic syndrome and related disorders: a
   systematic review and meta-analysis of randomized controlled trials
SO NUTRITION & METABOLISM
LA English
DT Review
DE Alpha-lipoic acid; Inflammatory markers; Meta-analysis
ID C-REACTIVE PROTEIN; CARDIOVASCULAR RISK-FACTORS; VITAMIN-E
   SUPPLEMENTATION; CORONARY-HEART-DISEASE; STAGE RENAL-DISEASE;
   NF-KAPPA-B; OXIDATIVE STRESS; TNF-ALPHA; SELENIUM SUPPLEMENTATION;
   ENDOTHELIAL DYSFUNCTION
AB Objective: This systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted to determine the effect of alpha-lipoic acid (ALA) supplementation on the inflammatory markers among patients with metabolic syndrome (MetS) and related disorders.
   Methods: We searched the following databases until November 2017: PubMed, MEDLINE, EMBASE, Web of Science, and Cochrane Central Register of Controlled Trials. Three reviewers independently assessed study eligibility, extracted data, and evaluated risk of bias of included primary studies. Statistical heterogeneity was assessed using Cochran's Q test and I-square (I-2) statistic. Data were pooled by using the random-effect model and standardized mean difference (SMD) was considered as the summary effect size.
   Results: Eighteen trials out of 912 potential citations were found to be eligible for our meta-analysis. The findings indicated that ALA supplementation significantly decreased C-reactive protein (CRP) (SMD = -1.52; 95% CI, -2.25, -0. 80; P < 0.001), interlokin-6 (IL-6) (SMD = -1.96; 95% CI, -2.60, -1.32; P < 0.001), and tumor necrosis factor alpha levels (TNF-alpha) (SMD=-2.62; 95% CI, -3.70, -1.55; P < 0.001) in patients diagnosed with metabolic diseases.
   Conclusion: In summary, the current meta-analysis demonstrated the promising impact of ALA administration on decreasing inflammatory markers such as CRP, IL-6 and TNF-alpha among patients with MetS and related disorders.
C1 [Akbari, Maryam; Tabrizi, Reza] Shiraz Univ Med Sci, Hlth Policy Res Ctr, Inst Hlth, Student Res Comm, Shiraz, Iran.
   [Ostadmohammadi, Vahidreza; Asemi, Zatollah] Kashan Univ Med Sci, Res Ctr Biochem & Nutr Metab Dis, Kashan, Iran.
   [Mobini, Moein] Univ Calgary, Kinesiol Dept, Calgary, AB, Canada.
   [Lankarani, Kamran B.; Heydari, Seyed Taghi] Shiraz Univ Med Sci, Hlth Policy Res Ctr, Inst Hlth, Shiraz, Iran.
   [Moosazadeh, Mahmood] Mazandaran Univ Med Sci, Hlth Sci Res Ctr, Addict Inst, Sari, Iran.
   [Chamani, Maryam] Iran Univ Med Sci, Sch Med, Dept Gynecol & Obstet, Tehran, Iran.
   [Kolandooz, Fariba] Univ Alberta, Dept Med, Indigenous & Global Hlth Res, Edmonton, AB, Canada.
C3 Shiraz University of Medical Science; University of Calgary; Shiraz
   University of Medical Science; Mazandaran University of Medical
   Sciences; Iran University of Medical Sciences; University of Alberta
RP Asemi, Z (corresponding author), Kashan Univ Med Sci, Res Ctr Biochem & Nutr Metab Dis, Kashan, Iran.; Chamani, M (corresponding author), Iran Univ Med Sci, Sch Med, Dept Gynecol & Obstet, Tehran, Iran.
EM Maryam.chamani.k@gmail.com; asemi_r@yahoo.com
RI asemi, zatollah/J-2677-2018; Tabrizi, Reza/AAC-2486-2021; Heydari,
   Seyed/U-9403-2019; Chamani, Maryam/Y-3396-2019; Lankarani,
   Kamran/P-5336-2019; Akbari, Ali/G-6044-2016; Ostadmohammadi,
   Vahidreza/A-6248-2018; Heydari, Seyyed Taghi/T-3309-2017; Asemi,
   Zatollah/G-7393-2017; moosazadeh, mahmood/F-3730-2017
OI Ostadmohammadi, Vahidreza/0000-0002-4633-5397; Heydari, Seyyed
   Taghi/0000-0001-7711-1137; Asemi, Zatollah/0000-0001-5265-4792;
   moosazadeh, mahmood/0000-0002-5452-514X; Heydari, Mohammad
   Hossein/0000-0001-6764-4394; tabrizi, reza/0000-0001-7634-3948
FU Shiraz University of Medical Sciences (SUMS)
FX The research grant provided by Research Deputy of Shiraz University of
   Medical Sciences (SUMS).
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NR 48
TC 55
Z9 55
U1 0
U2 15
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1743-7075
J9 NUTR METAB
JI Nutr. Metab.
PD JUN 5
PY 2018
VL 15
AR 39
DI 10.1186/s12986-018-0274-y
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA GI2JW
UT WOS:000434197400003
PM 29930690
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Lírio, LM
   Forechi, L
   Zanardo, TC
   Batista, HM
   Meira, EF
   Nogueira, BV
   Mill, JG
   Baldo, MP
AF Lirio, Layla Mendonca
   Forechi, Ludimila
   Zanardo, Tadeu Caliman
   Batista, Hiago Martins
   Meira, Eduardo Frizera
   Nogueira, Breno Valentim
   Mill, Jose Geraldo
   Baldo, Marcelo Perim
TI Chronic fructose intake accelerates non-alcoholic fatty liver disease in
   the presence of essential hypertension
SO JOURNAL OF DIABETES AND ITS COMPLICATIONS
LA English
DT Article
DE Fructose; Metabolic disorder; Visceral fat; Hypertension; Fat liver
   disease
ID INSULIN-RESISTANT RATS; METABOLIC SYNDROME; OXIDATIVE STRESS;
   CARDIOVASCULAR RISK; PROXIMAL TUBULE; GENE-EXPRESSION; BLOOD-PRESSURE;
   YOUNG-ADULTS; CORN SYRUP; PREVALENCE
AB Background: The growing epidemic of metabolic syndrome has been related to the increased use of fructose by the food industry. In fact, the use of fructose as an ingredient has increased in sweetened beverages, such as sodas and juices. We thus hypothesized that fructose intake by hypertensive rats would have a worse prognosis in developing metabolic disorder and non-alcoholic fatty liver disease.
   Methods: Male Wistar and SHR rats aged 6 weeks were given water or fructose (10%) for 6 weeks. Blood glucose was measured every two weeks, and insulin and glucose sensitivity tests were assessed at the end of the follow-up. Systolic blood pressure was measure by plethysmography. Lean mass and abdominal fat mass were collected and weighed. Liver tissue was analyzed to determine interstitial fat deposition and fibrosis.
   Results: Fasting glucose increased in animals that underwent a high fructose intake, independent of blood pressure levels. Also, insulin resistance was observed in normotensive and mostly in hypertensive rats after fructose intake. Fructose intake caused a 2.5-fold increase in triglycerides levels in both groups. Fructose intake did not change lean mass. However, we found that fructose intake significantly increased abdominal fat mass deposition in normotensive but not in hypertensive rats. Nevertheless, chronic fructose intake only increased fat deposition and fibrosis in the liver in hypertensive rats.
   Conclusions: We demonstrated that, in normotensive and hypertensive rats, fructose intake increased triglycerides and abdominal fat deposition, and caused insulin resistance. However, hypertensive rats that underwent fructose intake also developed interstitial fat deposition and fibrosis in liver. (C) 2016 Elsevier Inc. All rights reserved.
C1 [Lirio, Layla Mendonca; Forechi, Ludimila; Meira, Eduardo Frizera; Mill, Jose Geraldo; Baldo, Marcelo Perim] Univ Fed Espirito Santo, Dept Physiol Sci, Ave Marechal Campos 1468, BR-29042755 Vitoria, ES, Brazil.
   [Zanardo, Tadeu Caliman; Nogueira, Breno Valentim] Univ Fed Espirito Santo, Dept Morphol, Ave Marechal Campos 1468, BR-29042755 Vitoria, ES, Brazil.
   [Batista, Hiago Martins; Meira, Eduardo Frizera] Univ Fed Espirito Santo, Dept Pharm & Nutr, Rod Alto Univ, BR-29500000 Alegre, ES, Brazil.
C3 Universidade Federal do Espirito Santo; Universidade Federal do Espirito
   Santo; Universidade Federal do Espirito Santo
RP Baldo, MP (corresponding author), Univ Fed Espirito Santo, Dept Physiol Sci, Ave Marechal Campos 1468, BR-29042755 Vitoria, ES, Brazil.
EM marcelobaldo@ymail.com
RI Forechi, Ludimila/HNR-2321-2023; Meira, Eduardo/IVV-7442-2023; Baldo,
   Marcelo/G-6994-2012; NOGUEIRA, BRENO/O-7459-2016
OI NOGUEIRA, BRENO/0000-0002-2199-0635; Forechi,
   Ludimila/0000-0002-6657-0503; Baldo, Marcelo/0000-0002-7673-3580; Meira,
   Eduardo Frizzera/0000-0002-0210-4319
FU Conselho Nacional de Desenvolvimento Cientifico e Tecnologico-CNPq
   [470748/2013-3, 400484/2013-7]; CNPq [306028/2013-1]
FX This work was supported by grants from Conselho Nacional de
   Desenvolvimento Cientifico e Tecnologico-CNPq [470748/2013-3;
   400484/2013-7]. Marcelo Baldo is the recipient of a BJT fellowship from
   CNPq [306028/2013-1].
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NR 46
TC 26
Z9 28
U1 0
U2 11
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1056-8727
EI 1873-460X
J9 J DIABETES COMPLICAT
JI J. Diabetes Complications
PD JAN-FEB
PY 2016
VL 30
IS 1
BP 85
EP 92
DI 10.1016/j.jdiacomp.2015.10.008
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA DB5QH
UT WOS:000368568200017
PM 26597602
DA 2025-06-11
ER

PT J
AU Quines, CB
   Rosa, SG
   Chagas, PM
   da Rocha, JT
   Dobrachinski, F
   Carvalho, NR
   Soares, FA
   da Luz, SCA
   Nogueira, CW
AF Quines, Caroline B.
   Rosa, Suzan G.
   Chagas, Pietro M.
   da Rocha, Juliana T.
   Dobrachinski, Fernando
   Carvalho, Nelson R.
   Soares, Felix A.
   Almeida da Luz, Sonia C.
   Nogueira, Cristina W.
TI Homeostatic effect of p-chloro-diphenyl diselenide on glucose
   metabolism and mitochondrial function alterations induced by monosodium
   glutamate administration to rats
SO AMINO ACIDS
LA English
DT Article
DE Metabolic syndrome; Obesity; Monosodium glutamate; Organoselenium; Rats
ID FATTY LIVER-DISEASE; INSULIN-RESISTANCE; OXIDATIVE STRESS; OBESITY;
   TISSUE; MICE; SUPPLEMENTATION; ORGANOSELENIUM; INFLAMMATION; CHOLESTEROL
AB The metabolic syndrome is a group of metabolic alterations considered a worldwide public health problem. Organic selenium compounds have been reported to have many different pharmacological actions, such as anti-hypercholesterolemic and anti-hyperglycemic. The aim of this study was to evaluate the effect of p-chloro-diphenyl diselenide (p-ClPhSe)(2), an organic selenium compound, in a model of obesity induced by monosodium glutamate (MSG) administration in rats. The rats were treated during the first ten postnatal days with MSG and received (p-ClPhSe)(2) (10 mg/kg, intragastrically) from 45th to 51th postnatal day. Glucose, lipid and lactate levels were determined in plasma of rats. Glycogen levels and activities of tyrosine aminotransferase, hexokinase, citrate synthase and glucose-6-phosphatase (G-6-Pase) were determined in livers of rats. Renal G-6-Pase activity was also determined. The purine content [Adenosine triphosphate (ATP), adenosine diphosphate (ADP) and adenosine monophosphate] and mitochondrial functionality in the liver were also investigated. p-(ClPhSe)(2) did not alter the reduction in growth performance and in the body weight caused by MSG but reduced epididymal fat deposition of rats. p-(ClPhSe)(2) restored glycemia, triglycerides, cholesterol and lactate levels as well as the glucose metabolism altered in rats treated with MSG. p-(ClPhSe)(2) restored hepatic mitochondrial dysfunction and the decrease in citrate synthase activity and ATP and ADP levels caused by MSG in rats. In summary, (p-ClPhSe)(2) had homeostatic effects on glucose metabolism and mitochondrial function alterations induced by MSG administration to rats.
C1 [Quines, Caroline B.; Rosa, Suzan G.; Chagas, Pietro M.; da Rocha, Juliana T.; Nogueira, Cristina W.] Univ Fed Santa Maria, Ctr Ciencias Nat & Exatas, Lab Sintese Reatividade & Avaliacao Farmacol & To, BR-97105900 Santa Maria, RS, Brazil.
   [Dobrachinski, Fernando; Carvalho, Nelson R.; Soares, Felix A.; Nogueira, Cristina W.] Univ Fed Santa Maria, Ctr Ciencias Nat & Exatas, Dept Bioquim & Biol Mol, Campus UFSM, BR-97105900 Santa Maria, RS, Brazil.
   [Almeida da Luz, Sonia C.] Univ Fed Santa Maria, Dept Patol, BR-97105900 Santa Maria, RS, Brazil.
C3 Universidade Federal de Santa Maria (UFSM); Universidade Federal de
   Santa Maria (UFSM); Universidade Federal de Santa Maria (UFSM)
RP Nogueira, CW (corresponding author), Univ Fed Santa Maria, Ctr Ciencias Nat & Exatas, Lab Sintese Reatividade & Avaliacao Farmacol & To, BR-97105900 Santa Maria, RS, Brazil.; Nogueira, CW (corresponding author), Univ Fed Santa Maria, Ctr Ciencias Nat & Exatas, Dept Bioquim & Biol Mol, Campus UFSM, BR-97105900 Santa Maria, RS, Brazil.
EM criswn@ufsm.br
RI Nogueira, Cristina/H-1581-2012; Rosa, Suzan/F-6756-2018; Dobrachinski,
   Fernando/C-4316-2014; Maria Chagas, Pietro/E-6926-2015; Soares,
   Felix/K-7611-2012
OI Nogueira, Cristina W./0000-0003-2950-3632; Dobrachinski,
   Fernando/0000-0002-3948-1273; Rosa, Suzan/0000-0002-1832-982X; Carvalho,
   Nelson/0000-0001-9882-2050; Maria Chagas, Pietro/0000-0003-4336-5264;
   Soares, Felix/0000-0002-6453-7902
FU Universidade Federal de Santa Maria (UFSM); Coordenacao de
   Aperfeicoamento de Pessoal de Nivel Superior (CAPES); Conselho Nacional
   de Desenvolvimento Cientifico e Tecnologico (CNPq); Fundacao de Amparo a
   Pesquisa do Estado do Rio Grande do Sul; CNPq fellowship
FX We gratefully acknowledged the Universidade Federal de Santa Maria
   (UFSM), Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior
   (CAPES), Conselho Nacional de Desenvolvimento Cientifico e Tecnologico
   (CNPq) and Fundacao de Amparo a Pesquisa do Estado do Rio Grande do Sul
   for the financial support. C.W.N. is recipient of CNPq fellowship.
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NR 56
TC 20
Z9 20
U1 0
U2 14
PU SPRINGER WIEN
PI WIEN
PA SACHSENPLATZ 4-6, PO BOX 89, A-1201 WIEN, AUSTRIA
SN 0939-4451
EI 1438-2199
J9 AMINO ACIDS
JI Amino Acids
PD JAN
PY 2016
VL 48
IS 1
BP 137
EP 148
DI 10.1007/s00726-015-2073-3
PG 12
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA DC6CH
UT WOS:000369306900012
PM 26293481
DA 2025-06-11
ER

PT J
AU Leng, YR
   Zhang, MH
   Luo, JG
   Zhang, H
AF Leng Ying-Rong
   Zhang Mei-Hui
   Luo Jian-Guang
   Zhang Hao
TI Pathogenesis of NASH and Promising Natural Products
SO CHINESE JOURNAL OF NATURAL MEDICINES
LA English
DT Review
DE NASH; Natural medicine; Animal model; Target; Pathogenesis
ID FATTY LIVER-DISEASE; FARNESOID-X-RECEPTOR; CHOLINE-DEFICIENT DIET;
   HEPATIC STEATOSIS; NONALCOHOLIC STEATOHEPATITIS; OXIDATIVE STRESS;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; ANIMAL-MODELS; INTESTINAL
   MICROBIOTA
AB Nonalcoholic steatohepatitis (NASH) is a common clinical condition that can lead to advanced liver diseases. The mechanism of the diaease progression, which is lacking effective therapy, remains obsure. Therefore, there is a need to understand the pathogenic mechanisms responsible for disease development and progression in order to develop innovative therapies. To accomplish this goal, experimental animal models that recapitulate the human disease are necessary. Currently, an increasing number of studies have focused on natural constituents from medicinal plants which have been emerged as a new hope for NASH. This review summarized the pathogenesis of NASH, animal models commonly used, and the promising targets for therapeutics. We also reviewed the natural constituents as potential NASH therapeutic agents.
C1 [Luo Jian-Guang; Zhang Hao] China Pharmaceut Univ, State Key Lab Nat Med, Sch Tradit Chinese Pharm, Nanjing 210009, Peoples R China.
   China Pharmaceut Univ, Jiangsu Key Lab Bioact Nat Prod Res, Sch Tradit Chinese Pharm, Nanjing 210009, Peoples R China.
C3 China Pharmaceutical University; China Pharmaceutical University
RP Luo, JG; Zhang, H (corresponding author), China Pharmaceut Univ, State Key Lab Nat Med, Sch Tradit Chinese Pharm, Nanjing 210009, Peoples R China.
EM luojg@cpu.edu.cn; zhanghao@cpu.edu.cn
FU National Natural Science Foundation of China [81872889]; Drug Innovation
   Major Project [2018ZX09711-001-007, 2018ZX09735 002-003]
FX This work was supported by the National Natural Science Foundation of
   China (No. 81872889), and the Drug Innovation Major Project (Nos.
   2018ZX09711-001-007 and 2018ZX09735 002-003).
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NR 155
TC 26
Z9 29
U1 4
U2 47
PU CHINESE JOURNAL NATURAL MEDICINES
PI NANJING
PA 24, TONGJIA XIANG, NANJING, 210009, PEOPLES R CHINA
SN 2095-6975
EI 1875-5364
J9 CHIN J NAT MEDICINES
JI Chin. J. Nat. Med.
PD JAN
PY 2021
VL 19
IS 1
BP 12
EP 27
DI 10.1016/S1875-5364(21)60002-X
EA JAN 2021
PG 16
WC Integrative & Complementary Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine; Pharmacology & Pharmacy
GA QB1YX
UT WOS:000613940000002
PM 33516448
DA 2025-06-11
ER

PT J
AU Den Hartogh, DJ
   Gabriel, A
   Tsiani, E
AF Den Hartogh, Danja J.
   Gabriel, Alessandra
   Tsiani, Evangelia
TI Antidiabetic Properties of Curcumin II: Evidence from In Vivo Studies
SO NUTRIENTS
LA English
DT Review
DE insulin resistance; diabetes; curcumin; curcuminoids; in vivo; animal
   studies; human studies
ID INDUCED INFLAMMATORY RESPONSE; ATTENUATES OXIDATIVE STRESS; NF-KAPPA-B;
   DIABETIC-NEPHROPATHY; DOUBLE-BLIND; METABOLIC SYNDROME; ADIPOSE-TISSUE;
   BLOOD-GLUCOSE; LIPID-METABOLISM; NANO-CURCUMIN
AB Type 2 diabetes mellitus (T2DM) is a growing metabolic disease characterized by insulin resistance and hyperglycemia. Current preventative and treatment approaches to insulin resistance and T2DM lack in efficacy, resulting in the need for new approaches to prevent and treat the disease. In recent years, epidemiological studies have suggested that diets rich in fruits and vegetables have beneficial health effects, including protection against insulin resistance and T2DM. Curcumin, a polyphenol found in turmeric, and curcuminoids have been reported to have antioxidant, anti-inflammatory, hepatoprotective, nephroprotective, neuroprotective, immunomodulatory and antidiabetic properties. The current review (II of II) summarizes the existing in vivo studies examining the antidiabetic effects of curcumin.
C1 [Den Hartogh, Danja J.; Gabriel, Alessandra; Tsiani, Evangelia] Brock Univ, Dept Hlth Sci, St Catharines, ON L2S 3A1, Canada.
   [Den Hartogh, Danja J.; Tsiani, Evangelia] Brock Univ, Ctr Bone & Muscle Hlth, St Catharines, ON L2S 3A1, Canada.
C3 Brock University; Brock University
RP Tsiani, E (corresponding author), Brock Univ, Dept Hlth Sci, St Catharines, ON L2S 3A1, Canada.; Tsiani, E (corresponding author), Brock Univ, Ctr Bone & Muscle Hlth, St Catharines, ON L2S 3A1, Canada.
EM dd11qv@brocku.ca; ag15kh@brocku.ca; ltsiani@brocku.ca
OI Tsiani, Evangelia/0000-0003-4218-5851
FU Natural Sciences and Engineering Research Council of Canada (NSERC)
FX This was supported by a Natural Sciences and Engineering Research
   Council of Canada (NSERC) grant to E.T.
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NR 99
TC 44
Z9 47
U1 2
U2 19
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JAN
PY 2020
VL 12
IS 1
AR 58
DI 10.3390/nu12010058
PG 27
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA KQ3KN
UT WOS:000516825500058
PM 31881654
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Den Hartogh, DJ
   Tsiani, E
AF Den Hartogh, Danja J.
   Tsiani, Evangelia
TI Antidiabetic Properties of Naringenin: A Citrus Fruit Polyphenol
SO BIOMOLECULES
LA English
DT Review
DE insulin resistance; diabetes; naringenin; naringin; skeletal muscle;
   adipose; liver; pancreas
ID INSULIN-RESISTANCE; OXIDATIVE STRESS; IN-VIVO; FLAVONOID NARINGENIN;
   METABOLIC SYNDROME; HEPATIC STEATOSIS; LIPID-METABOLISM; ADIPOSE-TISSUE;
   GLUCOSE-UPTAKE; B SECRETION
AB Type 2 diabetes mellitus (T2DM) is a metabolic disease characterized by insulin resistance and hyperglycemia and is associated with personal health and global economic burdens. Current strategies/approaches of insulin resistance and T2DM prevention and treatment are lacking in efficacy resulting in the need for new preventative and targeted therapies. In recent years, epidemiological studies have suggested that diets rich in vegetables and fruits are associated with health benefits including protection against insulin resistance and T2DM. Naringenin, a citrus flavanone, has been reported to have antioxidant, anti-inflammatory, hepatoprotective, nephroprotective, immunomodulatory and antidiabetic properties. The current review summarizes the existing in vitro and in vivo animal studies examining the anti-diabetic effects of naringenin.
C1 [Den Hartogh, Danja J.; Tsiani, Evangelia] Brock Univ, Dept Hlth Sci, St Catharines, ON L2S 3A1, Canada.
   [Den Hartogh, Danja J.; Tsiani, Evangelia] Brock Univ, Ctr Bone & Muscle Hlth, St Catharines, ON L2S 3A1, Canada.
C3 Brock University; Brock University
RP Tsiani, E (corresponding author), Brock Univ, Dept Hlth Sci, St Catharines, ON L2S 3A1, Canada.; Tsiani, E (corresponding author), Brock Univ, Ctr Bone & Muscle Hlth, St Catharines, ON L2S 3A1, Canada.
EM dd11qv@brocku.ca; ltsiani@brocku.ca
OI Tsiani, Evangelia/0000-0003-4218-5851
FU Natural Sciences and Engineering Research Council of Canada (NSERC);
   Brock University Advancement Fund (BUAF); Brock Library Open Access
   Publishing Fund
FX This work was supported by a Natural Sciences and Engineering Research
   Council of Canada (NSERC) and by a Brock University Advancement Fund
   (BUAF) grant to E.T and a Brock Library Open Access Publishing Fund to
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NR 99
TC 163
Z9 168
U1 1
U2 49
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 2218-273X
J9 BIOMOLECULES
JI Biomolecules
PD MAR 12
PY 2019
VL 9
IS 3
AR 99
DI 10.3390/biom9030099
PG 21
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA HT2RU
UT WOS:000464411100002
PM 30871083
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Platt, C
   Coward, RJ
AF Platt, Caroline
   Coward, Richard J.
TI Peroxisome proliferator activating receptor-γ and the podocyte
SO NEPHROLOGY DIALYSIS TRANSPLANTATION
LA English
DT Review
DE kidney disease; podocyte; PPAR-gamma; PPAR-alpha; thiazolidinediones
ID ISCHEMIA-REPERFUSION INJURY; CAUSES INSULIN-RESISTANCE; INDUCED FLUID
   RETENTION; PPAR-GAMMA; KIDNEY-DISEASE; NEPHROTIC SYNDROME; METABOLIC
   SYNDROME; RENAL-DISEASE; MICE; EXPRESSION
AB Over the past two decades it has become clear that the glomerular podocyte is a key cell in preventing albuminuria, kidney failure and cardiovascular morbidity. Understanding the key pathways that protect the podocyte in times of glomerular stress, which can also be therapeutically manipulated, are highly attractive. In the following review we assess the evidence that the peroxisome proliferator activating receptor (PPAR) agonists are beneficial for podocyte and kidney function with a focus on PPAR-gamma. We explain our current understanding of the mechanisms of action of these agonists and the evidence they are beneficial in diabetic and non-diabetic kidney disease. We also outline why these drugs have not been widely used for kidney disease in the past but they may be in the future.
C1 [Platt, Caroline; Coward, Richard J.] Univ Bristol, Sch Clin Sci, Acad Children Renal Unit, Dorothy Hodgkin Bldg, Bristol, Avon, England.
C3 University of Bristol
RP Coward, RJ (corresponding author), Univ Bristol, Sch Clin Sci, Acad Children Renal Unit, Dorothy Hodgkin Bldg, Bristol, Avon, England.
EM richard.coward@bristol.ac.uk
OI Coward, Richard/0000-0001-6183-2546
FU Wellcome Trust;  [MR/K010492/1]; MRC [MR/K010492/1] Funding Source: UKRI
FX This work was supported by a Senior Clinical Fellowship to R.J.C.
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NR 88
TC 31
Z9 32
U1 0
U2 1
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0931-0509
EI 1460-2385
J9 NEPHROL DIAL TRANSPL
JI Nephrol. Dial. Transplant.
PD MAR
PY 2017
VL 32
IS 3
BP 423
EP 433
DI 10.1093/ndt/gfw320
PG 11
WC Transplantation; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Transplantation; Urology & Nephrology
GA EQ5IZ
UT WOS:000398117600008
PM 27697843
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Zhang, JW
   Yao, JM
   Zhao, Y
   Zheng, NN
   Dai, YY
AF Zhang, Juanwen
   Yao, Jinmei
   Zhao, Ying
   Zheng, Nengneng
   Dai, Yuying
TI Association Between Serum Free Fatty Acids Levels and Gestational
   Diabetes Mellitus: a Cross-Sectional Study
SO CLINICAL LABORATORY
LA English
DT Article
DE gestational diabetes mellitus; insulin resistance; free fatty acids
ID METABOLIC SYNDROME; PREGNANCY; LIPOLYSIS; STRESS; RISK
AB Background: This study aimed to assess the relationship between serum free fatty acid (FFA) levels and gestational diabetes mellitus (GDM) in Chinese pregnant women.
   Methods: A cross-sectional study was performed among 779 eligible pregnant women who underwent detailed prenatal visits in Hangzhou, China.
   Results: Patients with GDM had significantly higher serum FFA levels than those without GDM. Spearman's correlation analysis showed that FFA levels were positively correlated with fasting plasma glucose, 1hPG, 2hPG, HOMA-IR, triglyceride, and sialic acid (p < 0.05) and negatively correlated with serum amylase level (all with p < 0.05). Stepwise logistic regression analysis further showed that elevated FFA levels significantly contributed to the risk for GDM.
   Conclusions: Our findings suggested that serum FFA levels were significantly associated with GDM.
C1 [Zhang, Juanwen; Yao, Jinmei; Zhao, Ying] Zhejiang Univ, Affiliated Hosp 1, Dept Lab Med, Coll Med, Hangzhou 310003, Zhejiang, Peoples R China.
   [Zheng, Nengneng] Tongde Hosp Zhejiang Prov, Dept Gynecol & Obstet, Hangzhou 310012, Zhejiang, Peoples R China.
   [Dai, Yuying] Zhejiang Med Coll, Dept Clin Med, 481 Binwen Rd, Hangzhou 310053, Zhejiang, Peoples R China.
C3 Zhejiang University
RP Dai, YY (corresponding author), Zhejiang Med Coll, Dept Clin Med, 481 Binwen Rd, Hangzhou 310053, Zhejiang, Peoples R China.
EM Yydai2011@yeah.net
RI zhao, yingying/HHC-8693-2022
FU foundation of health bureau of Zhejiang Province, China [2016134574]
FX This work was supported by the foundation of health bureau of Zhejiang
   Province (No. 2016134574), China. This paper has been proofread by
   native English professionals with science backgrounds at Elixigen
   Corporation and Edanz Group. The fenders had no role in the study
   design, data collection and analysis, decision to publish, or
   preparation of the manuscript.
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NR 31
TC 2
Z9 2
U1 0
U2 25
PU CLIN LAB PUBL
PI HEIDELBERG
PA IM BREITSPIEL 15, HEIDELBERG, D-69126, GERMANY
SN 1433-6510
J9 CLIN LAB
JI Clin. Lab.
PY 2017
VL 63
IS 1
BP 15
EP 20
DI 10.7754/Clin.Lab.2016.160312
PG 6
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA EH8SR
UT WOS:000392043100002
PM 28164493
DA 2025-06-11
ER

PT J
AU Jones, NS
   Watson, KQ
   Rebeck, GW
AF Jones, Nahdia S.
   Watson, Katarina Q.
   Rebeck, G. William
TI Metabolic Disturbances of a High-Fat Diet Are Dependent on APOE Genotype
   and Sex
SO ENEURO
LA English
DT Article
DE apolipoprotein E; diet; metabolism; mouse model; obesity
ID BODY-MASS INDEX; BRAIN INSULIN-RESISTANCE; BROWN ADIPOSE-TISSUE;
   APOLIPOPROTEIN-E; COGNITIVE IMPAIRMENT; ALZHEIMER-DISEASE; RISK-FACTORS;
   OBESITY; DEMENTIA; MICE
AB Apolipoprotein E4 (APOE4) is the strongest genetic risk factor for Alzheimer's disease (AD). APOE4 is also associated with an increased risk of metabolic syndrome. Obesity is a major environmental risk factor for AD. While APOE genotype and obesity independently affect metabolism and cognition, they may also have synergistic effects. Here, we examined the metabolic and behavioral alterations associated with a high-fat diet (HFD) in male and female APOE knock-in mice. Male and female mice were fed a 45% kcal HFD or a 10% kcal low-fat diet (LFD) for 12 weeks and adipose tissue accumulation, glucose levels, anxiety-like behavior, and spatial memory were examined. We found that with HFD, male APOE4 mice were more susceptible to metabolic disturbances, including visceral adipose tissue (VAT) accumulation and glucose intolerance when compared to APOE3 mice, while female APOE3 and APOE4 mice had similar metabolic responses. Behaviorally, there were no effects of HFD in mice of either genotype. Our results suggest that metabolic responses to HFD are dependent on both sex and APOE genotype.
C1 [Jones, Nahdia S.; Watson, Katarina Q.; Rebeck, G. William] Georgetown Univ, Dept Neurosci, Washington, DC 20007 USA.
C3 Georgetown University
RP Rebeck, GW (corresponding author), Georgetown Univ, Dept Neurosci, Washington, DC 20007 USA.
EM gwr2@georgetown.edu
RI Rebeck, George/J-2192-2012
OI Rebeck, G. William/0000-0001-6276-248X
FU National Institutes of Health [R01 NS100704, NS100704-S1]
FX This work was supported by National Institutes of Health Grants R01
   NS100704 and NS100704-S1.
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NR 55
TC 39
Z9 44
U1 0
U2 0
PU SOC NEUROSCIENCE
PI WASHINGTON
PA 11 DUPONT CIRCLE, NW, STE 500, WASHINGTON, DC 20036 USA
EI 2373-2822
J9 ENEURO
JI eNeuro
PD SEP-OCT
PY 2019
VL 6
IS 5
AR 0267-19.2019
DI 10.1523/ENEURO.0267-19.2019
PG 11
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA JJ6QC
UT WOS:000494278900010
PM 31554665
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Björntorp, P
   Rosmond, P
AF Björntorp, P
   Rosmond, P
TI Obesity and cortisol
SO NUTRITION
LA English
DT Review
DE obesity; cortisol; sympathetic nervous system; sex steroid hormones;
   growth hormone; perinatal factors
ID BODY-FAT DISTRIBUTION; DEXAMETHASONE SUPPRESSION TEST; PITUITARY-ADRENAL
   AXIS; CORTICOTROPIN-RELEASING FACTOR; FRAGMENT-LENGTH-POLYMORPHISM;
   INSULIN-RESISTANCE SYNDROME; DIABETES-MELLITUS; 11-BETA-HYDROXYSTEROID
   DEHYDROGENASE; ABDOMINAL OBESITY; CUSHINGS-DISEASE
AB Cortisol in obesity is a much-studied problem. Previous information indicates that cortisol secretion is elevated but that circulatory concentrations are normal or low, suggesting that peripheral disappearance rate is elevated. These studies have usually not taken into account the difference between central and peripheral types of obesity. Recent studies using saliva cortisol have indicated that the problem is complex with both high and low secretion of cortisol, perhaps depending on the status of the function of the hypothalamic-pituitary-adrenal gland axis. A significant background factor seems to be environmental stress. The results also suggest that the pattern of cortisol secretion may be important. Other neuroendocrine pathways are also involved, including the central sympathetic nervous system, the gonadal and growth hormone axes, and the leptin system. In concert, these abnormalities seem to be responsible for the abnormal metabolism often seen in central obesity. Several associated polymorphisms of candidate genes may provide a genetic background. Cortisol conversion to inactive metabolites may be a factor increasing central signals to secretion and may add to the increased secretion of cortisol induced by centrally acting factors. Perinatal factors have been found to be involved in the pathogenesis of obesity and its complications. The mechanism involved is not known, but available information suggests that programming of the hypothalamic-pituitary-adrenal axis may be responsible. Nutrition 2000;16:924-936. (C) Elsevier Science Inc. 2000.
C1 Gothenburg Univ, Sahlgrens Hosp, Dept Heart & Lung Dis, S-41345 Gothenburg, Sweden.
   Louisiana State Univ, Pennington Biomed Res Ctr, Baton Rouge, LA 70808 USA.
C3 Sahlgrenska University Hospital; University of Gothenburg; Louisiana
   State University System; Louisiana State University; Pennington
   Biomedical Research Center
EM per.bjorntorp@hjl.gu.se
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NR 115
TC 455
Z9 518
U1 1
U2 63
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0899-9007
EI 1873-1244
J9 NUTRITION
JI Nutrition
PD OCT
PY 2000
VL 16
IS 10
BP 924
EP 936
DI 10.1016/S0899-9007(00)00422-6
PG 13
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 369HY
UT WOS:000165060900016
PM 11054598
DA 2025-06-11
ER

PT J
AU Varra, FN
   Varras, M
   Varra, VK
   Theodosis-Nobelos, P
AF Varra, Fani-Niki
   Varras, Michail
   Varra, Viktoria-Konstantina
   Theodosis-Nobelos, Panagiotis
TI Molecular and pathophysiological relationship between obesity and
   chronic inflammation in the manifestation of metabolic dysfunctions and
   their inflammation-mediating treatment options (Review)
SO MOLECULAR MEDICINE REPORTS
LA English
DT Review
DE obesity; oxidative stress; inflammation; mediators; cytokines;
   adipokines; metabolic syndrome; insulin resistance; type-2 diabetes
   mellitus
ID MONOCYTE CHEMOATTRACTANT PROTEIN-1; NECROSIS-FACTOR-ALPHA;
   PLASMINOGEN-ACTIVATOR INHIBITOR-1; TYPE-2 DIABETES-MELLITUS;
   DIET-INDUCED OBESITY; FATTY LIVER-DISEASE; CIRCULATING VISFATIN LEVEL;
   VASCULAR ENDOTHELIAL-CELLS; SYMPATHETIC-NERVOUS-SYSTEM; INDUCED
   INSULIN-RESISTANCE
AB Obesity reaches up to epidemic proportions globally and increases the risk for a wide spectrum of co-morbidities, including type-2 diabetes mellitus (T2DM), hypertension, dyslipidemia, cardiovascular diseases, non-alcoholic fatty liver disease, kidney diseases, respiratory disorders, sleep apnea, musculoskeletal disorders and osteoarthritis, subfertility, psychosocial problems and certain types of cancers. The underlying inflammatory mechanisms interconnecting obesity with metabolic dysfunction are not completely understood. Increased adiposity promotes pro-inflammatory polarization of macrophages toward the M1 phenotype, in adipose tissue (AT), with subsequent increased production of pro-inflammatory cytokines and adipokines, inducing therefore an overall, systemic, low-grade inflammation, which contributes to metabolic syndrome (MetS), insulin resistance (IR) and T2DM. Targeting inflammatory mediators could be alternative therapies to treat obesity, but their safety and efficacy remains to be studied further and confirmed in future clinical trials. The present review highlights the molecular and pathophysiological mechanisms by which the chronic low-grade inflammation in AT and the production of reactive oxygen species lead to MetS, IR and T2DM. In addition, focus is given on the role of anti-inflammatory agents, in the resolution of chronic inflammation, through the blockade of chemotactic factors, such as monocytes chemotractant protein-1, and/or the blockade of pro-inflammatory mediators, such as IL-1 beta, TNF-alpha, visfatin, and plasminogen activator inhibitor-1, and/or the increased synthesis of adipokines, such as adiponectin and apelin, in obesity-associated metabolic dysfunction.
C1 [Varra, Fani-Niki; Theodosis-Nobelos, Panagiotis] Frederick Univ, Sch Hlth Sci, Dept Pharm, CY-1036 Nicosia, Cyprus.
   [Varra, Fani-Niki] Dimocritus Univ Thrace, Med Sch, Alexandroupolis 68100, Greece.
   [Varras, Michail] Elena Venizelou Gen Hosp, Dept Obstet & Gynecol 4, 2 Elenas Venizelou Sq, Athens 11521, Greece.
   [Varra, Viktoria-Konstantina] Univ Patras, Sch Hlth Sci, Dept Pharm, Patras 26504, Greece.
C3 University of Patras
RP Varras, M (corresponding author), Elena Venizelou Gen Hosp, Dept Obstet & Gynecol 4, 2 Elenas Venizelou Sq, Athens 11521, Greece.
EM mnvarras@otenet.gr
RI Thedosis-Nobelos, Panagiotis/MCK-4639-2025
OI Thedosis-Nompelos, Panagiotis/0000-0003-3153-6425
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NR 388
TC 44
Z9 44
U1 20
U2 33
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1791-2997
EI 1791-3004
J9 MOL MED REP
JI Mol. Med. Rep.
PD JUN
PY 2024
VL 29
IS 6
AR 95
DI 10.3892/mmr.2024.13219
PG 27
WC Oncology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Research & Experimental Medicine
GA OC7D6
UT WOS:001205116700001
PM 38606791
OA hybrid
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Hayden, MR
AF Hayden, Melvin R.
TI The Mighty Mitochondria Are Unifying Organelles and Metabolic Hubs in
   Multiple Organs of Obesity, Insulin Resistance, Metabolic Syndrome, and
   Type 2 Diabetes: An Observational Ultrastructure Study
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE aberrant mitochondria; mitochondria; insulin resistance; type 2 diabetes
   mellitus; mtDNA; mtROS; fusion; fission; biogenesis; mitophagy
ID MOUSE CEREBRAL PERICYTES; ENDOTHELIAL GLYCOCALYX; OXIDATIVE STRESS;
   ALZHEIMERS-DISEASE; PHARMACOLOGICAL INHIBITION; NEUROVASCULAR UNIT;
   AORTIC STIFFNESS; BRAIN; HOMOCYSTEINE; DYSFUNCTION
AB Mitochondria (Mt) are essential cellular organelles for the production of energy and thermogenesis. Mt also serve a host of functions in addition to energy production, which include cell signaling, metabolism, cell death, and aging. Due to the central role of Mt in metabolism as metabolic hubs, there has been renewed interest in how Mt impact metabolic pathways and multiple pathologies. This review shares multiple observational ultrastructural findings in multiple cells and organs to depict aberrant mitochondrial (aMt) remodeling in pre-clinical rodent models. Further, it is intended to show how remodeling of Mt are associated with obesity, insulin resistance, metabolic syndrome (MetS), and type 2 diabetes mellitus (T2DM). Specifically, Mt remodeling in hypertensive and insulin-resistant lean models (Ren2 rat models), lean mice with streptozotocin-induced diabetes, obesity models including diet-induced obesity, genetic leptin-deficient ob/ob, and leptin receptor-deficient db/db diabetic mice are examined. Indeed, aMt dysfunction and damage have been implicated in multiple pathogenic diseases. Manipulation of Mt such as the induction of Mt biogenesis coupled with improvement of mitophagy machinery may be helpful to remove leaky damaged aMt in order to prevent the complications associated with the generation of superoxide-derived reactive oxygen species and the subsequent reactive species interactome. A better understanding of Mt remodeling may help to unlock many of the mysteries in obesity, insulin resistance, MetS, T2DM, and the associated complications of diabetic end-organ disease.
C1 [Hayden, Melvin R.] Univ Missouri, Diabet & Cardiovasc Dis Ctr, Dept Internal Med, Endocrinol Diabet & Metab,Sch Med, One Hosp Dr, Columbia, MO 65211 USA.
C3 University of Missouri System; University of Missouri Columbia
RP Hayden, MR (corresponding author), Univ Missouri, Diabet & Cardiovasc Dis Ctr, Dept Internal Med, Endocrinol Diabet & Metab,Sch Med, One Hosp Dr, Columbia, MO 65211 USA.
EM mrh29pete@gmail.com
OI Hayden, Melvin/0000-0001-5178-4245
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NR 114
TC 18
Z9 21
U1 1
U2 13
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD MAY
PY 2022
VL 23
IS 9
AR 4820
DI 10.3390/ijms23094820
PG 35
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 1F0YH
UT WOS:000794902000001
PM 35563211
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Heidemann, BE
   Wolters, FJ
   Kavousi, M
   Gruppen, EG
   Dullaart, RPF
   Marais, AD
   Visseren, FLJ
   Koopal, C
AF Heidemann, Britt E.
   Wolters, Frank J.
   Kavousi, Maryam
   Gruppen, Eke G.
   Dullaart, Robin P. F.
   Marais, A. David
   Visseren, Frank L. J.
   Koopal, Charlotte
TI Adiposity and the development of dyslipidemia in APOE ε2 homozygous
   subjects: A longitudinal analysis in two population-based cohorts
SO ATHEROSCLEROSIS
LA English
DT Article
DE APOE genotype; Familial dysbetalipoproteinemia; Lipids; Adiposity;
   Insulin resistance
ID III HYPERLIPOPROTEINEMIA; FAMILIAL DYSBETALIPOPROTEINEMIA;
   APOLIPOPROTEIN E2; LIPID-LEVELS; EXPRESSION; DIAGNOSIS; HYPERLIPIDEMIA;
   RISK
AB Background and aims: Familial dysbetalipoproteinemia (FD), characterized by remnant lipoprotein accumulation and premature cardiovascular disease, occurs in homozygous carriers of the APOE epsilon 2 allele, but genetic predisposition alone does not suffice for the clinical phenotype. Cross-sectional studies suggest that a second metabolic hit-notably adiposity or insulin resistance-is required, but the association between these risk factors and development of FD has not been studied prospectively.
   Methods: For this study, we evaluated 18,987 subjects from two large prospective Dutch population-based cohorts (PREVEND and Rotterdam Study) of whom 118 were homozygous APOE epsilon 2 carriers. Of these, 69 subjects were available for prospective analyses. Dyslipidemia-likely to be FD-was defined as fasting triglyceride (TG) levels >3 mmol/L in untreated subjects or use of lipid lowering medication. The effect of weight, body mass index (BMI), waist circumference, type 2 diabetes mellitus and non-TG metabolic syndrome on development of dyslipidemia was investigated.
   Results: Eleven of the 69 epsilon 2 epsilon 2 subjects (16%) developed dyslipidemia-likely FD-during follow-up. Age-, sexand cohort-adjusted risk factors for the development of FD were BMI (OR 1.19; 95%CI 1.04-1.39), waist circumference (OR 1.26 95%CI 1.01-1.61) and presence of non-TG metabolic syndrome (OR 4.39; 95%CI 1.04-18.4) at baseline. Change in adiposity during follow-up was not associated with development of dyslipidemia.
   Conclusions: Adiposity increases the risk of developing an FD-like lipid phenotype in homozygous APOE epsilon 2 subjects. These results stress the importance of healthy body weight in subjects at risk of developing FD.
C1 [Heidemann, Britt E.; Visseren, Frank L. J.; Koopal, Charlotte] Univ Utrecht, Univ Med Ctr Utrecht, Dept Vasc Med, Utrecht, Netherlands.
   [Wolters, Frank J.; Kavousi, Maryam] Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands.
   [Wolters, Frank J.] Erasmus MC, Dept Radiol & Nucl Med, Rotterdam, Netherlands.
   [Gruppen, Eke G.; Dullaart, Robin P. F.] Univ Groningen, Dept Endocrinol, Groningen, Netherlands.
   [Gruppen, Eke G.; Dullaart, Robin P. F.] Univ Groningen, Univ Med Ctr Groningen, Groningen, Netherlands.
   [Marais, A. David] Univ Cape Town, Fac Hlth Sci, Div Chem Pathol, Cape Town, South Africa.
C3 Utrecht University; Utrecht University Medical Center; Erasmus
   University Rotterdam; Erasmus MC; Erasmus University Rotterdam; Erasmus
   MC; University of Groningen; University of Groningen; University of Cape
   Town
RP Visseren, FLJ (corresponding author), Univ Med Ctr Utrecht, Dept Vasc Med, POB 85500, NL-3508 GA Utrecht, Netherlands.
EM F.L.J.Visseren@umcutrecht.nl
RI Wolters, Frank/AAQ-8535-2020; Kavousi, Maryam/F-1174-2018; Visseren,
   Frank/I-4855-2013
OI /0000-0003-2226-4050; Heidemann, Britt/0000-0001-5870-2417; Koopal,
   Charlotte/0000-0003-1487-1635
FU Dutch Kidney Foundation [E.033]; Dade Behring; Ausam; Roche; Abbott;
   Erasmus Medical Center; Erasmus University Rotterdam; Netherlands
   Organization for Scientific Research (NWO); Netherlands Organization for
   Health Research and Development (ZonMW); Research Institute for Diseases
   in the Elderly (RIDE); Netherlands Genomics Initiative; Ministry of
   Education, Culture and Science; Ministry of Health, Welfare and Sports;
   European Commission; Municipality of Rotterdam
FX The Dutch Kidney Foundation supported the infrastructure of the PREVEND
   program from 1997 to 2003 (Grant E.033) . The University Medical Center
   Groningen supported the infrastructure from 2003 to 2006. Dade Behring,
   Ausam, Roche, and Abbott financed laboratory equipment and reagents by
   which various laboratory determinations could be performed. The
   Rotterdam Study is supported by the Erasmus Medical Center and Erasmus
   University Rotterdam, The Netherlands Organization for Scientific
   Research (NWO) , The Netherlands Organization for Health Research and
   Development (ZonMW) , the Research Institute for Diseases in the Elderly
   (RIDE) , The Netherlands Genomics Initiative, the Ministry of Education,
   Culture and Science, the Ministry of Health, Welfare and Sports, the
   European Commission (DG XII) , and the Municipality of Rotterdam.
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NR 33
TC 13
Z9 13
U1 0
U2 3
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0021-9150
EI 1879-1484
J9 ATHEROSCLEROSIS
JI Atherosclerosis
PD MAY
PY 2021
VL 325
BP 57
EP 62
DI 10.1016/j.atherosclerosis.2021.04.001
EA APR 2021
PG 6
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA SD8HI
UT WOS:000651615900008
PM 33892328
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Guadagnini, D
   Rocha, GZ
   Santos, A
   Assalin, HB
   Hirabara, SM
   Curi, R
   Oliveira, AG
   Prada, PO
   Saad, MJA
AF Guadagnini, Dioze
   Rocha, Guilherme Zweig
   Santos, Andrey
   Assalin, Heloisa Balan
   Hirabara, Sandro Massao
   Curi, Rui
   Oliveira, Alexandre Gabarra
   Prada, Patricia O.
   Saad, Mario J. A.
TI Microbiota determines insulin sensitivity in TLR2-KO mice
SO LIFE SCIENCES
LA English
DT Article
DE Gut microbiota; Insulin resistance; LPS; Genetic protection; TLR2
ID DIET-INDUCED OBESITY; GUT MICROBIOTA; HIGH-FAT; INTESTINAL MICROBIOTA;
   RECEPTOR SUBSTRATE-1; INDUCED INFLAMMATION; METABOLIC SYNDROME; HOST
   PHYSIOLOGY; ANIMAL-MODELS; RESISTANCE
AB Introduction: Environmental factors have a key role in the control of gut microbiota and obesity. TLR2 knockout (TLR2(-/-)) mice in some housing conditions are protected from diet-induced insulin resistance. However, in our housing conditions these animals are not protected from diet-induced insulin-resistance.
   Aim: The aim of the present study was to investigate the influence of our animal housing conditions on the gut microbiota, glucose tolerance and insulin sensitivity in TLR2(-/-) mice.
   Material and methods: The microbiota was investigated by metagenomics, associated with hyperinsulinemic euglycemic clamp and GTT associated with insulin signaling through immunoblotting.
   Results: The results showed that TLR2(-/-) mice in our housing conditions presented a phenotype of metabolic syndrome characterized by insulin resistance, glucose intolerance and increase in body weight. This phenotype was associated with differences in microbiota in TLR2(-/-) mice that showed a decrease in the Proteobacteria and Bacteroidetes phyla and an increase in the Firmicutesphylum, associated with and in increase in the Oscillospira and Ruminococcus genera. Furthermore there is also an increase in circulating LPS and subclinical inflammation in TLR2(-/-). The molecular mechanism that account for insulin resistance was an activation of TLR4, associated with ER stress and JNK activation. The phenotype and metabolic behavior was reversed by antibiotic treatment and reproduced in WT mice by microbiota transplantation.
   Conclusions: Our data show, for the first time, that the intestinal microbiota can induce insulin resistance and obesity in an animal model that is genetically protected from these processes.
C1 [Guadagnini, Dioze; Rocha, Guilherme Zweig; Santos, Andrey; Assalin, Heloisa Balan; Oliveira, Alexandre Gabarra; Saad, Mario J. A.] Univ Estadual Campinas, UNICAMP, Dept Internal Med FCM, Campinas, SP, Brazil.
   [Hirabara, Sandro Massao; Curi, Rui] Cruzeiro do Sul Univ, Interdisciplinary Postgrad Program Hlth Sci, Sao Paulo, Brazil.
   [Oliveira, Alexandre Gabarra] Sao Paulo State Univ UNESP, Dept Phys Educ, Biosci Inst, Rio Claro, SP, Brazil.
   [Prada, Patricia O.] Univ Estadual Campinas, Sch Appl Sci, Grad Program Nutr & Sport Sci & Metab, UNICAMP, Campinas, SP, Brazil.
C3 Universidade Estadual de Campinas; Universidade Estadual Paulista;
   Universidade Estadual de Campinas
RP Saad, MJA (corresponding author), Rua Tessalia Vieira Camargo 126, BR-13084971 Campinas, SP, Brazil.
EM msaad@fcm.unicamp.br
RI Assalin, Heloisa/F-5933-2016; Saad, Mario/ABD-8262-2020; Prada,
   Patricia/JED-6381-2023; Curi, Rui/AAT-7970-2021; OLIVEIRA,
   ALEXANDRE/D-1288-2013; dos Santos, Andrey/J-8648-2014; Rocha,
   Guilherme/J-9146-2014; Hirabara, Sandro Massao/C-4014-2012
OI OLIVEIRA, ALEXANDRE/0000-0002-6620-5477; de Oliveira Prada,
   Patricia/0000-0002-4245-8867; dos Santos, Andrey/0000-0003-2922-3032;
   Rocha, Guilherme/0000-0002-7403-3230; Hirabara, Sandro
   Massao/0000-0002-7392-0444; CURI, RUI/0000-0001-5095-9154
FU CAPES/CNPq (Conselho Nacional de Desenvolvimento Cientifico e
   Tecnologico) [465693/2014-8]
FX We also acknowledge the financial support INCT de Obesidade e Diabetes
   465693/2014-8 (FAPESP) and CAPES/CNPq (Conselho Nacional de
   Desenvolvimento Cientifico e Tecnologico).
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NR 74
TC 20
Z9 22
U1 0
U2 17
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0024-3205
EI 1879-0631
J9 LIFE SCI
JI Life Sci.
PD OCT 1
PY 2019
VL 234
AR 116793
DI 10.1016/j.lfs.2019.116793
PG 12
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA JA6EF
UT WOS:000487934500017
PM 31465735
DA 2025-06-11
ER

PT J
AU Rohini, A
   Agrawal, N
   Kumar, H
   Nath, V
   Kumar, V
AF Rohini, A.
   Agrawal, Neeraj
   Kumar, Harish
   Nath, Virendra
   Kumar, Vipin
TI Norbixin, an apocarotenoid derivative activates PPARγ in cardiometabolic
   syndrome: Validation by in silico and in vivo experimental assessment
SO LIFE SCIENCES
LA English
DT Article
DE Cardio-metabolic syndrome; High fat diet; Norbixin; PPAR gamma;
   Molecular docking; Molecular dynamics
ID INSULIN-RESISTANCE; ALPHA; TROGLITAZONE; EXPRESSION; DISCOVERY;
   EFFICIENT; GLUCOSE; ANNATTO; LIVER; MODEL
AB The increased prevalence of cardio-metabolic disorders worldwide prompted the exploration of new strategies for its treatment. Peroxisome Proliferator activated receptor (PPAR) play major role in regulation of lipid as well as glucose metabolism and thus, natural PPAR gamma activators seem to be drug of choice.
   Aims: In the present work, we studied norbixin which is a natural apocarotenoid derivative for its agonistic activity for PPAR gamma followed by in vivo studies for amelioration of cardio-metabolic syndrome (CMetS).
   Main methods: The methods include computational studies, TR-FRET binding analysis and in vivo studies on high fat diet induced rats.
   Key findings: Molecular docking and molecular dynamics (MD) simulation studies showed that norbixin could be embedded into hydrophobic pocket of PPAR gamma and stable hydrogen bonding interactions were found with residues Glu273, Tyr327, Ser289, His323, His449 and Tyr473 of PPAR gamma These results were substantiated by significant in vitro PPAR agonistic activity of norbixin in TR-FRET binding assay studies. The experimental results of norbixin in high fat diet induced CMetS in rats further confirmed that norbixin decreased insulin resistance (IR), hyperglycemia and dyslipidemia. These results were accompanied by reduced inflammatory marker hs-CRP as well as decreased oxidative stress and arterial pressure. The histopathology of heart sections also showed that norbixin could prevent the abnormal fibrotic changes in heart. Furthermore, PPAR gamma protein expressions were increased, whereas NF-kappa B expression was decreased by norbixin treatment in western blot studies.
   Significance: These results validate norbixin as a novel PPAR gamma agonist and prove therapeutic potential of norbixin in treatment of CMetS.
C1 [Rohini, A.; Kumar, Harish; Nath, Virendra; Kumar, Vipin] Cent Univ Rajasthan, Sch Chem Sci & Pharm, Dept Pharm, Ajmer, India.
   [Agrawal, Neeraj] Kashi Inst Pharm, Varanasi, Uttar Pradesh, India.
C3 Central University of Rajasthan (CURAJ)
RP Kumar, V (corresponding author), Cent Univ Rajasthan, Sch Chem Sci & Pharm, Dept Pharm, Ajmer, India.
EM vipbhardwaj@rediffmail.com
RI Nath, Dr. Virendra/AAM-5528-2020; Kumar, Vipin/KMY-0355-2024; Kumar,
   Harish/AAM-5383-2021
FU National-Post Doctoral Fellowship (N-PDF) from Science and Engineering
   Research Board (SERB), New Delhi, Government of India. [PDF/2015/001063]
FX This work was supported by the National-Post Doctoral Fellowship (N-PDF)
   from Science and Engineering Research Board (SERB), New Delhi,
   Government of India. (FILE NO. PDF/2015/001063).
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NR 37
TC 13
Z9 13
U1 1
U2 5
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0024-3205
EI 1879-0631
J9 LIFE SCI
JI Life Sci.
PD SEP 15
PY 2018
VL 209
BP 69
EP 77
DI 10.1016/j.lfs.2018.08.001
PG 9
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA GS5SE
UT WOS:000443730000010
PM 30076922
DA 2025-06-11
ER

PT J
AU Corrigan, FE
   Kelli, HM
   Dhindsa, DS
   Heinl, RE
   Al Mheid, I
   Hammadah, M
   Hayek, SS
   Sher, S
   Eapen, DJ
   Martin, GS
   Quyyumi, AA
AF Corrigan, Frank E., III
   Kelli, Heval Mohamed
   Dhindsa, Devinder S.
   Heinl, Robert E.
   Al Mheid, Ibhar
   Hammadah, Muhammad
   Hayek, Salim S.
   Sher, Salman
   Eapen, Danny J.
   Martin, Greg S.
   Quyyumi, Arshed A.
TI Changes in truncal obesity and fat distribution predict arterial health
SO JOURNAL OF CLINICAL LIPIDOLOGY
LA English
DT Article
DE Truncal obesity; Body mass index; Dual-energy X-ray absorptiometry;
   Arterial stiffness; Pulse wave velocity
ID X-RAY ABSORPTIOMETRY; DISEASE RISK-FACTORS; METABOLIC SYNDROME;
   BODY-COMPOSITION; ENDOTHELIAL FUNCTION; OXIDATIVE STRESS;
   ADIPOSE-TISSUE; STIFFNESS; ASSOCIATION; ADULTS
AB BACKGROUND: Truncal obesity is associated with metabolic syndrome and cardiovascular risk. Although vascular health is influenced by weight, it is not known whether changes in fat distribution modulate arterial function.
   OBJECTIVE: We assessed how changes in truncal (android) fat at 1 year affect arterial stiffness and endothelial function.
   METHODS: We recruited 711 healthy volunteers (235 males, age 48 +/- 11 years) into the Emory Predictive Health Study; 498 returned at 1 year. Measurements included anthropometric and chemistry panels, fat mass using dual-energy X-ray absorptiometry, arterial stiffness indices (pulse wave velocity [PWV], augmentation index [AIx], and subendocardial viability ratio [SEVR]; Sphygmocor), flow-mediated dilation (FMD), and reactive hyperemia index (Endo-PAT).
   RESULTS: At baseline, measures of body mass correlated with PWV, AIx, SEVR, and FMD. In a multivariable analysis including body mass index (BMI) and traditional risk factors, BMI remained an independent predictor of PWV, AIx, SEVR, and FMD. In a model including BMI and measures of fat distribution, android fat remained an independent predictor of PWV (beta = 0.31, P = .004), AIx (beta = 0.24, P = .008), and SEVR (beta = -0.41, P < .001). The 1-year change in android fat correlated negatively with change in SEVR (beta = -0.13, P = .005) and FMD (beta = -0.13, P = .006) after adjustment for change in gynoid fat.
   CONCLUSION: In addition to BMI, android fat is a determinant of arterial stiffness, independent of traditional risk factors. Changes in android fat over time are associated with simultaneous changes in vascular function, indicating fat distribution's effect on vascular health. (C) 2017 National Lipid Association. All rights reserved.
C1 [Corrigan, Frank E., III; Kelli, Heval Mohamed; Dhindsa, Devinder S.; Heinl, Robert E.; Al Mheid, Ibhar; Hammadah, Muhammad; Hayek, Salim S.; Sher, Salman; Eapen, Danny J.; Quyyumi, Arshed A.] Emory Univ, Sch Med, Dept Med, Div Cardiol, 101 Woodruff Circle,WMB 308, Atlanta, GA 30322 USA.
   [Sher, Salman; Martin, Greg S.; Quyyumi, Arshed A.] Emory Georgia Tech Predict Hlth Inst, Atlanta, GA USA.
   [Martin, Greg S.] Emory Univ, Sch Med, Dept Med, Div Pulm & Crit Care Med, Atlanta, GA USA.
C3 Emory University; Emory University
RP Corrigan, FE (corresponding author), Emory Univ, Sch Med, Dept Med, Div Cardiol, 101 Woodruff Circle,WMB 308, Atlanta, GA 30322 USA.
EM fcorrig@emory.edu
RI Hayek, Salim/E-6932-2013; Martin, Greg/B-4085-2009
OI Hayek, Salim/0000-0003-0180-349X; Martin, Greg/0000-0002-9684-7593;
   Corrigan, Frank/0000-0002-1815-8813
FU American Heart Association; Emory Predictive Health Institute; Woodruff
   Fund; National Institutes of Health Grants from Clinical and
   Translational Science Award program [UL1RR025008, M01RR0039]
FX This study was supported by the American Heart Association, The Emory
   Predictive Health Institute, Woodruff Fund, and in part by National
   Institutes of Health Grants UL1RR025008 from the Clinical and
   Translational Science Award program and M01RR0039.
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NR 40
TC 20
Z9 20
U1 0
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1933-2874
EI 1876-4789
J9 J CLIN LIPIDOL
JI J. Clin. Lipidol.
PD DEC
PY 2017
VL 11
IS 6
BP 1354
EP 1360
DI 10.1016/j.jacl.2017.08.013
PG 7
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA FP6YM
UT WOS:000417773500008
PM 28942095
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Camargo, A
   Rangel-Zúñiga, OA
   Alcalá-Díaz, J
   Gomez-Delgado, F
   Delgado-Lista, J
   García-Carpintero, S
   Marín, C
   Almadén, Y
   Yubero-Serrano, EM
   López-Moreno, J
   Tinahones, FJ
   Pérez-Martínez, P
   Roche, HM
   López-Miranda, J
AF Camargo, A.
   Rangel-Zuniga, O. A.
   Alcala-Diaz, J.
   Gomez-Delgado, F.
   Delgado-Lista, J.
   Garcia-Carpintero, S.
   Marin, C.
   Almaden, Y.
   Yubero-Serrano, E. M.
   Lopez-Moreno, J.
   Tinahones, F. J.
   Perez-Martinez, P.
   Roche, H. M.
   Lopez-Miranda, J.
TI Dietary fat may modulate adipose tissue homeostasis through the
   processes of autophagy and apoptosis
SO EUROPEAN JOURNAL OF NUTRITION
LA English
DT Article
DE Obesity; Autophagy; Apoptosis; Insulin resistance; Dietary fat
ID BETA-CELL MASS; METABOLIC SYNDROME; STRESS; OBESITY; DEATH; DEGRADATION;
   DEFINES; PROTEIN
AB Obesity increases the risk of cardiovascular disease, type 2 diabetes mellitus and cancer development. Autophagy and apoptosis are critical processes for development and homeostasis in multicellular organisms and have been linked to a variety of disorders. We aimed to investigate whether the quantity and quality of dietary fat can influence these processes in the adipose tissue of obese people.
   A randomized, controlled trial within the LIPGENE study assigned 39 obese people with metabolic syndrome to 1 of 4 diets: (a) a high-saturated fatty acid diet, (b) a high-monounsaturated fatty acid (HMUFA) diet, and (c, d) two low-fat, high-complex carbohydrate diets supplemented with long-chain n-3 polyunsaturated fatty acids (LFHCC n-3) or placebo (LFHCC), for 12 weeks each.
   We found an increase in the expression of autophagy-related BECN1 and ATG7 genes after the long-term consumption of the HMUFA diet (p = 0.001 and p = 0.004, respectively) and an increase in the expression of the apoptosis-related CASP3 gene after the long-term consumption of the LFHCC and LFHCC n-3 diets (p = 0.001 and p = 0.029, respectively). CASP3 and CASP7 gene expression changes correlated with HOMA index.
   Our results suggest that the processes of autophagy and apoptosis in adipose tissue may be modified by diet and that the consumption of a diet rich in monounsaturated fat may contribute to adipose tissue homeostasis by increasing autophagy. They also reinforce the notion that apoptosis in adipose tissue is linked to insulin resistance.
   ClinicalTrials.gov NCT00429195.
C1 [Camargo, A.; Rangel-Zuniga, O. A.; Alcala-Diaz, J.; Gomez-Delgado, F.; Delgado-Lista, J.; Garcia-Carpintero, S.; Marin, C.; Almaden, Y.; Yubero-Serrano, E. M.; Lopez-Moreno, J.; Perez-Martinez, P.; Lopez-Miranda, J.] Univ Cordoba, Reina Sofia Univ Hosp, IMIBIC, Lipids & Atherosclerosis Unit, Ave Menendez Pidal S-N, E-14004 Cordoba, Spain.
   [Camargo, A.; Rangel-Zuniga, O. A.; Alcala-Diaz, J.; Gomez-Delgado, F.; Delgado-Lista, J.; Garcia-Carpintero, S.; Marin, C.; Almaden, Y.; Yubero-Serrano, E. M.; Lopez-Moreno, J.; Tinahones, F. J.; Perez-Martinez, P.; Lopez-Miranda, J.] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr CIBEROBN, Cordoba, Spain.
   [Tinahones, F. J.] Hosp Virgen de la Victoria, Endocrinol & Nutr Serv, Malaga, Spain.
   [Roche, H. M.] Univ Coll Dublin, UCD Inst Food & Hlth, UCD Conway Inst, Sch Publ Hlth & Populat Sci, Dublin, Ireland.
C3 Universidad de Cordoba; CIBER - Centro de Investigacion Biomedica en
   Red; CIBEROBN; Instituto de Salud Carlos III; University College Dublin
RP López-Miranda, J (corresponding author), Univ Cordoba, Reina Sofia Univ Hosp, IMIBIC, Lipids & Atherosclerosis Unit, Ave Menendez Pidal S-N, E-14004 Cordoba, Spain.; López-Miranda, J (corresponding author), Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr CIBEROBN, Cordoba, Spain.
EM jlopezmir@uco.es
RI Marin Hinojosa, Carmen/AFO-1294-2022; Lopez-Miranda, Jose/Y-8306-2019;
   YUBERO, ELENA/AFM-2738-2022; Roche, Helen/AAF-4164-2019; Alcala-Diaz,
   Juan/Q-4455-2019; Tinahones, Francisco/AAB-2882-2020; Delgado-Lista,
   Javier/KAM-7412-2024; Garcia Carpintero, Sonia/W-1261-2017; Gomez
   Delgado, Francisco/H-4552-2015; Camargo Garcia, Antonio/G-9720-2015;
   Perez Martinez, Pablo/AEL-6176-2022
OI Gomez Delgado, Francisco/0000-0002-0216-2084; Lopez-Miranda,
   Jose/0000-0002-8844-0718; Tinahones, Francisco J/0000-0001-6871-4403;
   Roche, Helen/0000-0002-0628-3318; Delgado Lista, Francisco
   Javier/0000-0002-2982-2716; Alcala-Diaz, Juan
   Francisco/0000-0002-4572-3611; Camargo Garcia,
   Antonio/0000-0002-0415-4184; Perez Martinez, Pablo/0000-0001-7716-8117;
   Garcia Carpintero Fernandez Pacheco, Sonia/0000-0003-3403-3209;
   Yubero-Serrano, Elena M/0000-0002-2733-5359; Rangel-Zuniga, Oriol
   Alberto/0000-0003-3495-5705
FU European Union (LIPGENE European Integrated Project) [505944];
   Ministerio de Ciencia e Innovacion [AGL2004-07907, AGL2006-01979,
   AGL2009-2270]; Ministerio de Economia y Competitividad [AGL2012/39615,
   PIE14/00005, PIE 14/00031]; CIBER Fisiopatologia de la Obesidad y
   Nutricion [CB06/03/0047]; Consejeria de Innovacion, Ciencia y Empresa,
   Junta de Andalucia [P06- CTS-01425, CVI-7450]; Consejeria de Salud,
   Junta de Andalucia [06/128, 07/43, PI-0193]; Fondo Europeo de Desarrollo
   Regional (FEDER); Instituto de Salud Carlos III research contract
   (Programa Miguel-Servet) [CP14/00114]
FX The CIBEROBN is an initiative of the Instituto de Salud Carlos III,
   Madrid, Spain. This work was supported in part by Research Grants from
   the European Union (LIPGENE European Integrated Project-505944), from
   the Ministerio de Ciencia e Innovacion [Grant Numbers AGL2004-07907,
   AGL2006-01979, AGL2009-2270 (to J.L.-M.)]; Ministerio de Economia y
   Competitividad [AGL2012/39615, PIE14/00005, PIE 14/00031 (to J L-M)];
   CIBER Fisiopatologia de la Obesidad y Nutricion [Grant Number
   CB06/03/0047]; Consejeria de Innovacion, Ciencia y Empresa, Junta de
   Andalucia [Grant Number P06- CTS-01425 and CVI-7450 (to J.L.-M.); and
   Consejeria de Salud, Junta de Andalucia [Grant Numbers 06/128, 07/43,
   PI-0193 (to J.L.-M.)].); Fondo Europeo de Desarrollo Regional (FEDER).
   Antonio Camargo is supported by an Instituto de Salud Carlos III
   research contract (Programa Miguel-Servet CP14/00114).
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NR 34
TC 20
Z9 20
U1 0
U2 22
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1436-6207
EI 1436-6215
J9 EUR J NUTR
JI Eur. J. Nutr.
PD JUN
PY 2017
VL 56
IS 4
BP 1621
EP 1628
DI 10.1007/s00394-016-1208-y
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA EX7ZU
UT WOS:000403469100021
PM 27029919
DA 2025-06-11
ER

PT J
AU Ojeda, ML
   Nogales, F
   del Valle, PM
   Díaz-Castro, J
   Murillo, ML
   Carreras, O
AF Luisa Ojeda, M.
   Nogales, Fatima
   Munoz del Valle, Paulina
   Diaz-Castro, Javier
   Luisa Murillo, M.
   Carreras, Olimpia
TI Metabolic syndrome and selenium in fetal programming: gender differences
SO FOOD & FUNCTION
LA English
DT Article
ID MATERNAL FRUCTOSE-INTAKE; INSULIN SENSITIVITY; OXIDATIVE STRESS; ADULT
   MALE; PREGNANCY; LACTATION; GLUCOSE; RATS; SUPPLEMENTATION; GESTATION
AB Objectives: Since Selenium (Se) forms part of glutathione peroxidase (GPx), which appears to have a dual role in Metabolic Syndrome (MS), this study evaluates the implication of Se in the transmission of this pathology to the progeny. Methods: Se body distribution, glucose, triglycerides, cholesterol, insulin and metabolic hormones [glucagon, leptin, gastric inhibitory polypeptide (GIP), and triiodothyronine (T3)], growth factors, receptor activator of nuclear factor kappa-B ligand (RANK-L) and osteopontin, as well as oxidative hepatic balance in the offspring of dams exposed to a fructose-rich diet (65%) with normal Se content (0.01 ppm) during gestation and lactation, were measured according to sex. Results: Fructose pups had lower body weight; however, male pups had a lower body mass index and growth indicators in serum. Fructose pups, especially females, had lower levels of serum insulin and HOMA-IR. With regard to Se homeostasis, fructose pups presented a depletion of Se in heart and muscle, and repletion in kidneys, pancreas and thyroid, although only female pups showed a repletion of Se in the liver. Fructose pups presented lower superoxide dismutase activity and only female fructose pups had higher GPx activity, which provoked hepatic oxidation. Conclusions: Se balance and Se tissue deposits in MS pups during lactation are altered by gender. This difference is focused on hepatic Se deposits that affect GPx activity, which could be related to a disruption in the insulin-signaling cascade in females. Furthermore, although female fructose pups had greater metabolic disorders, only the males' growth and development were affected. Particularly relevant is the depletion of Se found in the heart of fructose pups, as this element is essential for correct heart function.
C1 [Luisa Ojeda, M.; Nogales, Fatima; Munoz del Valle, Paulina; Luisa Murillo, M.; Carreras, Olimpia] Univ Seville, Fac Pharm, Dept Physiol, E-41012 Seville, Spain.
   [Diaz-Castro, Javier] Univ Granada, Fac Pharm, Dept Physiol, E-18071 Granada, Spain.
   [Diaz-Castro, Javier] Univ Granada, Inst Nutr & Food Technol Jose Mataix, E-18071 Granada, Spain.
C3 University of Sevilla; University of Granada; University of Granada
RP Carreras, O (corresponding author), Univ Seville, Fac Pharm, Dept Physiol, E-41012 Seville, Spain.
EM olimpia@us.es
RI Nogales, F/B-8562-2019; Ojeda, Luisa/B-8571-2019; Carreras,
   olimpia/P-9078-2019; Diaz-Castro, Javier/H-2985-2015
OI Carreras, Olimpia/0000-0002-3858-0165; Maria Luisa, Ojeda
   Murillo/0000-0002-9160-2749; Diaz-Castro, Javier/0000-0003-3659-1757;
   Nogales, Fatima/0000-0003-4844-2740
FU Andalusian Regional Government
FX Grants from Andalusian Regional Government for its support to CTS-193
   research group.
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NR 41
TC 13
Z9 13
U1 1
U2 11
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PY 2016
VL 7
IS 7
BP 3031
EP 3038
DI 10.1039/c6fo00595k
PG 8
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA DR7SB
UT WOS:000380098900009
PM 27334401
DA 2025-06-11
ER

PT J
AU Arismendi, E
   Rivas, E
   Agustí, A
   Ríos, J
   Barreiro, E
   Vidal, J
   Rodriguez-Roisin, R
AF Arismendi, Ebymar
   Rivas, Eva
   Agusti, Alvar
   Rios, Jose
   Barreiro, Esther
   Vidal, Josep
   Rodriguez-Roisin, Robert
TI The Systemic Inflammome of Severe Obesity before and after Bariatric
   Surgery
SO PLOS ONE
LA English
DT Article
ID GASTRIC BYPASS-SURGERY; ADIPOSE-TISSUE; INCREASED 8-ISOPROSTANE;
   CARDIOVASCULAR RISK; BREATH CONDENSATE; OXIDATIVE STRESS; INFLAMMATION;
   ASTHMA; NETWORK; STANDARDIZATION
AB Introduction: Obesity is associated with low-grade systemic inflammation. The "inflammome'' is a network layout of the inflammatory pattern. The systemic inflammome of obesity has not been described as yet. We hypothesized that it can be significantly worsened by smoking and other comorbidities frequently associated with obesity, and ameliorated by bariatric surgery (BS). Besides, whether or not these changes are mirrored in the lungs is unknown, but obesity is often associated with pulmonary inflammation and bronchial hyperresponsiveness.
   Objectives: We sought to: (1) describe the systemic inflammome of morbid obesity; (2) investigate the effects of sex, smoking, sleep apnea syndrome, metabolic syndrome and BS upon this systemic inflammome; and, (3) determine their interplay with pulmonary inflammation.
   Methods: We studied 129 morbidly obese patients (96 females; age 46 +/- 12 years; body mass index [BMI], 46 +/- 6 kg/m(2)) before and one year after BS, and 20 healthy, never-smokers, (43 +/- 7 years), with normal BMI and spirometry.
   Results: Before BS, compared with controls, all obese subjects displayed a strong and coordinated (inflammome) systemic inflammatory response (adiponectin, C-reactive protein, interleukin (IL)-8, IL-10, leptin, soluble tumor necrosis factor-receptor 1(sTNF-R1), and 8-isoprostane). This inflammome was not modified by sex, smoking, or coexistence of obstructive sleep apnea and/or metabolic syndrome. By contrast, it was significantly ameliorated, albeit not completely abolished, after BS. Finally, obese subjects had evidence of pulmonary inflammation (exhaled condensate) that also decreased after BS.
   Conclusions: The systemic inflammome of morbid obesity is independent of sex, smoking status and/or comorbidities, it is significantly reduced by BS and mirrored in the lungs.
C1 [Arismendi, Ebymar; Agusti, Alvar; Rodriguez-Roisin, Robert] Hosp Clin Barcelona, Inst Clin Torax, Serv Pneumol, Barcelona, Spain.
   [Arismendi, Ebymar; Agusti, Alvar; Vidal, Josep; Rodriguez-Roisin, Robert] Hosp Clin Barcelona, Fundacio Clin Recerca Biomed, Barcelona, Spain.
   [Arismendi, Ebymar; Agusti, Alvar; Barreiro, Esther; Rodriguez-Roisin, Robert] CIBER Enfermedades Resp CIBERES, Barcelona, Spain.
   [Arismendi, Ebymar; Agusti, Alvar; Barreiro, Esther; Rodriguez-Roisin, Robert] CIBER Enfermedades Resp CIBERES, Palma De Mallorca, Spain.
   [Arismendi, Ebymar; Rivas, Eva; Agusti, Alvar; Rios, Jose; Vidal, Josep; Rodriguez-Roisin, Robert] Univ Barcelona, Inst Invest Biomed August Pi i Sunyer IDIBAPS, Barcelona, Spain.
   [Rivas, Eva] Hosp Clin Barcelona, Serv Anestesiol & Reanimacio, Barcelona, Spain.
   [Rios, Jose] Univ Autonoma Barcelona, Biostat & Data Management Core Facil, Biostat Unit, E-08193 Barcelona, Spain.
   [Barreiro, Esther] Hosp del Mar, Dept Pulmonol, Barcelona, Spain.
   [Barreiro, Esther] Univ Pompeu Fabra, PRBB, Barcelona, Spain.
   [Vidal, Josep] Hosp Clin Barcelona, Serv Endocrinol, Inst Clin Malalties Digest & Metab, Barcelona, Spain.
C3 University of Barcelona; Hospital Clinic de Barcelona; University of
   Barcelona; Hospital Clinic de Barcelona; CIBER - Centro de Investigacion
   Biomedica en Red; CIBERES; CIBER - Centro de Investigacion Biomedica en
   Red; CIBERES; University of Barcelona; Hospital Clinic de Barcelona;
   IDIBAPS; University of Barcelona; Hospital Clinic de Barcelona;
   Autonomous University of Barcelona; Hospital del Mar Research Institute;
   Hospital del Mar; Pompeu Fabra University; Barcelona Biomedical Research
   Park; University of Barcelona; Hospital Clinic de Barcelona
RP Rodriguez-Roisin, R (corresponding author), Hosp Clin Barcelona, Inst Clin Torax, Serv Pneumol, Barcelona, Spain.
EM rororo@clinic.ub.es
RI Rivas, Eva/AFU-7933-2022; Barreiro, E/D-6919-2014; Vidal,
   Josep/MIK-6936-2025; Agusti Garcia-Navarro, Alvar/F-4474-2015; Rios,
   Jose/AAZ-2341-2020
OI Rivas, Eva/0000-0002-5816-998X; Agusti Garcia-Navarro,
   Alvar/0000-0003-3271-3788; Rios, Jose/0000-0002-0716-8784; Arismendi,
   Ebymar/0000-0002-7749-2838; Vidal Cortada, Josep/0000-0002-4564-4518
FU Fondo de Investigacion Sanitaria (FIS) [PI080311]; CIBERES; Generalitat
   de Catalunya [2009SGR00911]; Almirall
FX This work was supported by Fondo de Investigacion Sanitaria (FIS)
   PI080311, CIBERES, Generalitat de Catalunya (2009SGR00911) and an
   unrestricted grant by Almirall. The funders had no role in study design,
   data collection and analysis, decision to publish, or preparation of the
   manuscript.
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NR 45
TC 40
Z9 43
U1 0
U2 7
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD SEP 19
PY 2014
VL 9
IS 9
AR e107859
DI 10.1371/journal.pone.0107859
PG 7
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA AQ0RY
UT WOS:000342491600057
PM 25238542
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Stojakovic, T
   Scharnagl, H
   Trauner, M
   Pieske, B
   Wellnitz, B
   Seelhorst, U
   Schilling, D
   Winkelmann, BR
   Boehm, BO
   März, W
AF Stojakovic, Tatjana
   Scharnagl, Hubert
   Trauner, Michael
   Pieske, Burkert
   Wellnitz, Britta
   Seelhorst, Ursula
   Schilling, Dieter
   Winkelmann, Bernhard R.
   Boehm, Bernhard O.
   Maerz, Winfried
TI Serum gamma-glutamyl transferase and mortality in persons undergoing
   coronary angiography-The Ludwigshafen Risk and Cardiovascular Health
   Study
SO ATHEROSCLEROSIS
LA English
DT Article
DE Cardiovascular disease; Gamma-glutamyl transferase; Mortality; Risk
   factor
ID FATTY LIVER-DISEASE; MIDDLE-AGED MEN; ALANINE AMINOTRANSFERASE;
   METABOLIC SYNDROME; MYOCARDIAL-INFARCTION; OXIDATIVE STRESS;
   HEART-DISEASE; GLUTAMYLTRANSFERASE; ATHEROSCLEROSIS; TRANSPEPTIDASE
AB Objective: Serum gamma-glutamyl transferase (GGT) seems to be a predictor for coronary artery disease (CAD). The objective of this study was to elucidate the relationship between GGT and total as well as cardiovascular mortality.
   Methods: Serum levels of GGT were determined in 2556 subjects with and 699 subjects without angiographic evidence of CAD in the Ludwigshafen Risk and Cardiovascular Health (LURIC) study.
   Results: Serum GGT was positively associated with male gender, alcohol consumption and markers of the metabolic syndrome (triglycerides, blood pressure, waist circumference and insulin resistance). It was positively related to aspartate aminotransferase, alanine aminotransferase, C-reactive protein, interleukin-6, and negatively related to glutathione and increased age. During a mean follow-up period of 7.75 years, 754 subjects died. Compared with subjects in the lowest quartile of GGT, the unadjusted hazard ratios (95% CI) for all-cause death were 1.2 (0.9-1.5), 1.4 (1.1-1.8) and 1.9 (1.5-2.3), respectively, in other GGT quartiles. Hazard ratios (CI) for death from cardiovascular causes were 1.4 (1.0-2.0), 1.8 (1.4-2.5) and 2.2 (1.6-2.9). After adjustment for age, gender and cardiovascular risk factors GGT remained a significant predictor for total and cardiovascular mortality. In angiographic CAD the predictive value of GGT was also significant and similar to that in the entire cohort.
   Conclusion: Serum GGT is predictive of all-cause and cardiovascular mortality in individuals with CAD independently of other cardiovascular risk factors. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
C1 [Stojakovic, Tatjana; Scharnagl, Hubert; Maerz, Winfried] Med Univ Graz, Clin Inst Med & Chem Lab Diagnost, A-8036 Graz, Austria.
   [Trauner, Michael] Med Univ Graz, Dept Internal Med, Div Gastroenterol & Hepatol, A-8036 Graz, Austria.
   [Pieske, Burkert] Med Univ Graz, Dept Cardiol, A-8036 Graz, Austria.
   [Wellnitz, Britta; Seelhorst, Ursula] LURIC Study Nonprofit LLC, Freiburg, Germany.
   [Schilling, Dieter] Diakonie Hosp, Dept Gastroenterol & Metab, Mannheim, Germany.
   [Winkelmann, Bernhard R.] Cardiol Grp Frankfurt Sachsenhausen, Frankfurt, Germany.
   [Boehm, Bernhard O.] Univ Ulm, Dept Internal Med 1, Div Endocrinol & Diabet, D-89069 Ulm, Germany.
   [Maerz, Winfried] Synlab Ctr Lab Diagnost, Heidelberg, Germany.
C3 Medical University of Graz; Medical University of Graz; Medical
   University of Graz; Ulm University; SYNLAB Group
RP Stojakovic, T (corresponding author), Med Univ Graz, Clin Inst Med & Chem Lab Diagnost, Auenbruggerpl 15, A-8036 Graz, Austria.
EM tatjana.stojakovic@medunigraz.at
RI Pieske, Burkert/M-8089-2016; Boehm, Bernhard/F-8750-2015; Trauner,
   Michael/HCH-4032-2022
OI Trauner, Michael/0000-0002-1275-6425
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NR 40
TC 43
Z9 45
U1 0
U2 5
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0021-9150
EI 1879-1484
J9 ATHEROSCLEROSIS
JI Atherosclerosis
PD FEB
PY 2010
VL 208
IS 2
BP 564
EP 571
DI 10.1016/j.atherosclerosis.2009.07.026
PG 8
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 548TK
UT WOS:000273989200046
PM 19695568
DA 2025-06-11
ER

PT J
AU Cárdenas, G
   Torres, JC
   Zamora, J
   Baños, G
AF Cárdenas, G
   Torres, JC
   Zamora, J
   Baños, G
TI Isolated heart function during ischemia and reperfusion in sucrose-fed
   rats.: Effect of insulin infusion
SO CARDIOVASCULAR PATHOLOGY
LA English
DT Article
DE metabolic syndrome; rat heart ischemia-reperfusion; insulin; sucrose-fed
   rats
ID ACUTE MYOCARDIAL-INFARCTION; HYPERTENSIVE-RATS; POTASSIUM;
   HYPERTRIGLYCERIDEMIA; ENDOTHELIN; ESTROGEN; RELEASE; BLOOD; CELLS; SERUM
AB In myocardial damage due to ischemia-reperfusion, the administration of insulin together with glucose and potassium may be protective, although in some patients and animal models, it is ineffective. In a rat model (HTG) with characteristics of the metabolic syndrome, induced by sucrose feeding, ischemia-reperfusion of the isolated heart evidences a less favorable outcome than in control animals, particularly males. We investigated the effect of insulin infusion during the reperfusion period in isolated hearts from control and HTG male and female rats. Weanling Wistar rats were given commercial rat chow and tap water (C rats) or 30% sucrose solution (HTG rats) for 8 months. They developed moderate hypertension and hyperinsulinemia, central adiposity, nephropathy, and hypertriglyceridemia. Cardiac function was recorded in a Langendorff preparation subjected to 25 min ischemia and 15 min reperfusion. The handicapped functionality of HTG hearts is more apparent under conditions of stress. Insulin administration improved particularly mechanical work and +dp/dt max variables. The effect of sex was observed on the type of arrhythmias developed during reperfusion: Only the males showed lethal ventricular fibrillation, which disappeared after insulin administration. Females had lower levels of cardiac enzymes creatine kinase (CKMB) and lactic dehydrogenase (LDH), but their performance was not hindered, probably on account of protective factors such as estrogens. Summing up, the pathological features of the HTG model did not prevent insulin from exerting some of its beneficial effects in HTG hearts. Sex differences in the outcome were more apparent in the type of arrhythmias after reperfusion; they were lethal in HTG males only, but insulin prevented their onset. (c) 2005 Elsevier Inc. All rights reserved.
C1 Inst Nacl Cadiol Ignacio Chavez, Dept Biochem, Tlalpan 14080, Mexico.
   Inst Nacl Cadiol Ignacio Chavez, Dept Pharmacol, Tlalpan 14080, Mexico.
   Inst Nacl Cadiol Ignacio Chavez, Dept Endocrinol, Tlalpan 14080, Mexico.
RP Inst Nacl Cadiol Ignacio Chavez, Dept Biochem, Tlalpan 14080, Mexico.
EM gbanos@yahoo.com
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NR 31
TC 9
Z9 12
U1 0
U2 4
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1054-8807
EI 1879-1336
J9 CARDIOVASC PATHOL
JI Cardiovasc. Pathol.
PD SEP-OCT
PY 2005
VL 14
IS 5
BP 256
EP 264
DI 10.1016/j.carpath.2005.06.004
PG 9
WC Cardiac & Cardiovascular Systems; Pathology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Pathology
GA 972KK
UT WOS:000232452500006
PM 16168899
DA 2025-06-11
ER

PT J
AU Asghar, ZA
   Cusumano, A
   Yan, ZH
   Remedi, MS
   Moley, KH
AF Asghar, Zeenat A.
   Cusumano, Andrew
   Yan, Zihan
   Remedi, Maria S.
   Moley, Kelle H.
TI Reduced islet function contributes to impaired glucose homeostasis in
   fructose-fed mice
SO AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
LA English
DT Article
ID PANCREATIC ALPHA-CELLS; BETA-CELL; GLUCAGON-SECRETION;
   INSULIN-SECRETION; DIABETES-MELLITUS; MOUSE MODEL; TRANSPORTERS;
   EXPRESSION; STRESS; HYPERGLUCAGONEMIA
AB Increased sugar consumption, particularly fructose, in the form of sweetened beverages and sweeteners in our diet adversely affects metabolic health. Because these effects are associated with features of the metabolic syndrome in humans, the direct effect of fructose on pancreatic islet function is unknown. Therefore, we examined the islet phenotype of mice fed excess fructose. Fructose-fed mice exhibited fasting hyperglycemia and glucose intolerance but not hyperinsulinemia, dyslipidemia, or hyperuricemia. Islet function was impaired, with decreased glucose-stimulated insulin secretion and increased glucagon secretion and high fructose consumption leading to alpha-cell proliferation and upregulation of the fructose transporter GLUT5, which was localized only in alpha-cells. Our studies demonstrate that excess fructose consumption contributes to hyperglycemia by affecting both beta-and alpha-cells of islets in mice.
C1 [Asghar, Zeenat A.; Cusumano, Andrew; Moley, Kelle H.] Washington Univ, Sch Med, Dept Obstet & Gynecol, 660 South Euclid Ave, St Louis, MO 63110 USA.
   [Yan, Zihan; Remedi, Maria S.] Washington Univ, Sch Med, Dept Med, St Louis, MO 63110 USA.
C3 Washington University (WUSTL); Washington University (WUSTL)
RP Moley, KH (corresponding author), Washington Univ, Sch Med, Dept Obstet & Gynecol, 660 South Euclid Ave, St Louis, MO 63110 USA.
EM moleyk@wudosis.wustl.edu
RI yan, zihan/KVY-5472-2024
OI Shyr, Zeenat/0000-0001-8710-9938; Remedi, Maria S/0000-0003-2048-472X
FU American Diabetes Association Research [76274]; National Institute of
   Diabetes and Digestive and Kidney Diseases [R01-DK-098584]
FX This work was supported by American Diabetes Association Research Grant
   76274 to K. H. Moley and by National Institute of Diabetes and Digestive
   and Kidney Diseases Grant R01-DK-098584 to M. S. Remedi.
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NR 53
TC 9
Z9 9
U1 1
U2 16
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0193-1849
EI 1522-1555
J9 AM J PHYSIOL-ENDOC M
JI Am. J. Physiol.-Endocrinol. Metab.
PD FEB
PY 2017
VL 312
IS 2
BP E109
EP E116
DI 10.1152/ajpendo.00279.2016
PG 8
WC Endocrinology & Metabolism; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Physiology
GA EN1XL
UT WOS:000395803600003
PM 28028036
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Regnell, SE
AF Regnell, Simon Eringsmark
TI Cannabinoid 1 receptor in fatty liver
SO HEPATOLOGY RESEARCH
LA English
DT Review
DE cannabinoid receptor CB1; fatty liver; hepatic steatosis; non-alcoholic
   fatty liver disease; sterol regulatory element-binding protein 1c
ID ELEMENT-BINDING PROTEIN-1C; PROLIFERATOR-ACTIVATED RECEPTOR;
   ENDOPLASMIC-RETICULUM STRESS; HEPATIC STEATOSIS; INSULIN SENSITIVITY;
   TRANSCRIPTION FACTORS; ENERGY HOMEOSTASIS; METABOLIC SYNDROME;
   LIPID-METABOLISM; CB1 RECEPTOR
AB The role of cannabinoids in fatty liver disease has been increasingly acknowledged in recent years, and it has been suggested that drugs targeting peripheral cannabinoid receptors could have therapeutic use. Development of such drugs would require a good understanding of the mechanisms of fat accumulation caused by cannabinoid receptor activation. This review describes in detail the enzymatic steps that lead from the stimulation of cannabinoid 1 receptor to steatosis. It identifies several signaling pathways that activate sterol regulatory element-binding protein 1c (SREBP-1c), the key transcription factor causing fatty liver. The downstream effects of SREBP-1c leading to increased fatty acid synthesis and decreased fatty acid oxidation are also described.
C1 [Regnell, Simon Eringsmark] Lund Univ, S-22184 Lund, Sweden.
C3 Lund University
RP Regnell, SE (corresponding author), Lund Univ, BMC, Solvegatan 19, S-22184 Lund, Sweden.
EM fek09sre@student.lu.se
OI Regnell, Simon/0000-0002-6672-8972
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NR 78
TC 14
Z9 14
U1 0
U2 13
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1386-6346
J9 HEPATOL RES
JI Hepatol. Res.
PD FEB
PY 2013
VL 43
IS 2
BP 131
EP 138
DI 10.1111/j.1872-034X.2012.01085.x
PG 8
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 092TB
UT WOS:000315144100005
PM 22994399
OA Bronze
DA 2025-06-11
ER

PT J
AU Cahlíková, L
   Macáková, K
   Chlebek, J
   Host'álková, A
   Kulhánková, A
   Opletal, L
AF Cahlikova, Lucie
   Macakova, Katerina
   Chlebek, Jakub
   Host'alkova, Anna
   Kulhankova, Andrea
   Opletal, Lubomir
TI Ecdysterone and its Activity on some Degenerative Diseases
SO NATURAL PRODUCT COMMUNICATIONS
LA English
DT Review
DE Ecdysterone; biological activity; degenerative diseases; prospective
   application
ID SUPERCRITICAL-FLUID EXTRACTION; INDUCIBLE EXPRESSION; PROTEIN-SYNTHESIS;
   20-HYDROXYECDYSONE; PHYTOECDYSTEROIDS; METABOLISM; ECDYSONE; HORMONES
AB Beside ecdysone (1), ecdysterone (2) is one of the most common 5 beta-cholest-7-en-6-one (ecdysteroid) derivatives, which, besides having a hormonal effect on invertebrates, possesses a number of favorable non-hormonal biological effects on mammals. The most interesting of these is that on degenerative diseases, one of which, up to now not clarified in detail, is the so-called adaptogenic effect (protection of the organism against adverse stress factors) associated with anabolic, gastroprotective, and antioxidant effects. A second group of favorable effects is the possibility of suppression of neurodegenerative processes and protection of the cardiovascular system (metabolic syndrome symptom suppression, antidiabetic activity, and protection of heart and blood vessels). Because of these properties, ecdysterone has the potential to be developed as a medicinal agent.
C1 [Cahlikova, Lucie; Macakova, Katerina; Chlebek, Jakub; Host'alkova, Anna; Kulhankova, Andrea; Opletal, Lubomir] Charles Univ Prague, Dept Pharmaceut Bot & Ecol, ADINACO Res Grp, Fac Pharm Hradec Kralove, Hradec Kralove 50005, Czech Republic.
C3 Charles University Prague
RP Cahlíková, L (corresponding author), Charles Univ Prague, Dept Pharmaceut Bot & Ecol, ADINACO Res Grp, Fac Pharm Hradec Kralove, Heyrovskeho 1203, Hradec Kralove 50005, Czech Republic.
EM opletal@faf.cuni.cz
RI Chlebek, Jakub/T-3466-2017; Macakova, Katerina/S-9312-2017; Opletal,
   Lubomir/H-5254-2012; Cahlikova, Lucie/T-5670-2017; Hostalkova,
   Anna/O-3934-2014
OI Chlebek, Jakub/0000-0002-0697-5242; Macakova,
   Katerina/0000-0003-2805-8741; Opletal, Lubomir/0000-0002-3874-3729;
   Cahlikova, Lucie/0000-0002-1555-8870; Hostalkova,
   Anna/0000-0003-3205-3767
FU Specific Universities Research of the Czech Republic [SVV/2011/263002]
FX This study was supported by Specific Universities Research of the Czech
   Republic No. SVV/2011/263002.
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NR 135
TC 18
Z9 20
U1 0
U2 15
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1934-578X
EI 1555-9475
J9 NAT PROD COMMUN
JI Nat. Prod. Commun.
PD MAY
PY 2011
VL 6
IS 5
BP 707
EP 718
PG 12
WC Chemistry, Medicinal; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Food Science & Technology
GA 762UF
UT WOS:000290506200031
PM 21615037
DA 2025-06-11
ER

PT J
AU Amati, F
AF Amati, F.
TI Revisiting the diacylglycerol-induced insulin resistance hypothesis
SO OBESITY REVIEWS
LA English
DT Article
DE GL/FFA cycle; lipid droplets; lipotoxicity; type 2 diabetes
ID PROTEIN-KINASE-C; HUMAN SKELETAL-MUSCLE; FATTY-ACID OXIDATION; DE-NOVO
   LIPOGENESIS; INTRAMYOCELLULAR LIPIDS; OBESE SUBJECTS; METABOLIC
   SYNDROME; DIABETES-MELLITUS; GLUCOSE-UPTAKE; WEIGHT-LOSS
AB Obesity is associated with skeletal muscle insulin resistance, which is a crucial step in the development of type 2 diabetes. Among the mechanisms by which obesity may lead to insulin resistance, lipotoxicity is one of the hypotheses being explored; others include inflammation or the oxidative stress hypotheses. This review focuses on the role of diacylglycerols (DAG), a family of lipid metabolites implicated in the pathogenesis of lipotoxicity and insulin resistance. While recent studies report contradictory results in humans with regard to the importance of DAG-induced insulin resistance in skeletal muscle, other current literature highlight a potential role for DAG as signalling molecules. This review will discuss possible hypotheses explaining these contradictory results and the need to explore further the role of DAG in human metabolism.
C1 Univ Lausanne, Dept Physiol, CH-1005 Lausanne, Switzerland.
C3 University of Lausanne
RP Amati, F (corresponding author), Univ Lausanne, Dept Physiol, 7 Bugnon, CH-1005 Lausanne, Switzerland.
EM Francesca.amati@unil.ch
RI Amati, Francesca/A-6326-2011
OI Amati, Francesca/0000-0002-1731-0262
FU Swiss National Research Foundation [Ambizione PZ00P3-126339]
FX This work was, in part, supported by the Swiss National Research
   Foundation (grant Ambizione PZ00P3-126339).
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NR 81
TC 42
Z9 50
U1 0
U2 19
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1467-7881
EI 1467-789X
J9 OBES REV
JI Obes. Rev.
PD DEC
PY 2012
VL 13
SU 2
SI SI
BP 40
EP 50
DI 10.1111/j.1467-789X.2012.01036.x
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 030FK
UT WOS:000310555000005
PM 23107258
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Ozawa, K
   Miyazaki, M
   Matsuhisa, M
   Takano, K
   Nakatani, Y
   Hatazaki, M
   Tamatani, T
   Yamagata, K
   Miyagawa, JI
   Kitao, Y
   Hori, O
   Yamasaki, Y
   Ogawa, S
AF Ozawa, K
   Miyazaki, M
   Matsuhisa, M
   Takano, K
   Nakatani, Y
   Hatazaki, M
   Tamatani, T
   Yamagata, K
   Miyagawa, JI
   Kitao, Y
   Hori, O
   Yamasaki, Y
   Ogawa, S
TI The endoplasmic reticulum chaperone improves insulin resistance in type
   2 diabetes
SO DIABETES
LA English
DT Article
ID OXYGEN-REGULATED PROTEIN; PANCREATIC BETA-CELLS; TRANSLATIONAL CONTROL;
   METABOLIC SYNDROME; GLUCOSE-PRODUCTION; GENE-EXPRESSION; ORP150; STRESS;
   MOUSE; MICE
AB To determine the role of the endoplasmic reticulum (ER) in diabetes, Akita mice, a mouse model of type 2 diabetes, were mated with either heterozygous knockout mice or two types of transgenic mice of 150-kDa oxygen-regulated protein (ORP150), a molecular chaperone located in the ER. Systemic expression of ORP150 in Akita mice improves insulin intolerance, whereas the exclusive overexpression of ORP150 in pancreatic beta-cells of Akita mice did not change their glucose tolerance. Both an insulin tolerance test and hyperinsulinemiceuglycemic clamp revealed that ORP150 enhanced glucose uptake, accompanied by suppression of oxidized protein. Furthermore, ORP150 enhanced the insulin sensitivity of myoblast cells treated with hydrogen peroxide. These data suggest that ORP150 plays an important role in insulin sensitivity and is a potential target for the treatment of diabetes.
C1 Kanazawa Univ, Sch Med, Dept Neuroanat, Kanazawa, Ishikawa 9208640, Japan.
   Dainippon Pharmaceut Co, Dept Discovery Pharmacol 2, Pharmacol & Microbiol Res Labs, Drug Res Dis, Suita, Osaka, Japan.
   Osaka Univ, Grad Sch Med, Dept Internal Med & Therapeut, Suita, Osaka, Japan.
   Kanazawa Univ, Grad Sch Nat Sci & Technol, Mol Pharmacol Lab, Kanazawa, Ishikawa, Japan.
   Osaka Univ, Grad Sch Med, Dept Internal Med & Mol Sci, Suita, Osaka, Japan.
C3 Kanazawa University; The University of Osaka; Kanazawa University; The
   University of Osaka
RP Ozawa, K (corresponding author), Kanazawa Univ, Sch Med, Dept Neuroanat, 13-1 Takara Machi, Kanazawa, Ishikawa 9208640, Japan.
EM k.ozawa@mbi.nifty.com
RI Takano-Kawabe, Katsura/JDW-6520-2023
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NR 30
TC 172
Z9 199
U1 0
U2 9
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0012-1797
J9 DIABETES
JI Diabetes
PD MAR
PY 2005
VL 54
IS 3
BP 657
EP 663
DI 10.2337/diabetes.54.3.657
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 903KB
UT WOS:000227423600009
PM 15734840
OA Bronze
DA 2025-06-11
ER

PT J
AU Ghafoor, S
AF Ghafoor, Saadia
TI Impact of Obesity and Weight Management on Women with Polycystic Ovary
   Syndrome and Coexisting Obesity-A Brief Narrative Review
SO AKTUALNI GYNEKOLOGIE A PORODNICTVI
LA English
DT Review
DE PCOS; Obesity; Overweight; Weight Loss; Polycystic Ovary Syndrome;
   Exercise; Lifestyle inter-vention; Bariatric surgery
ID LIFE-STYLE; NUTRITIONAL MANAGEMENT; DIETARY-COMPOSITION; ENDOMETRIAL
   CANCER; INSULIN-RESISTANCE; HYPOCALORIC DIET; ANXIETY SYMPTOMS;
   OVERWEIGHT WOMEN; EXERCISE; RISK
AB Obesity, an ongoing pandemic, is associated with obesity-related androgenic, reproductive, and metabolic comorbidities in females. Polycystic Ovary Syndrome (PCOS) is a multifaceted endocrinopathy that common-ly manifests with hyperandrogenic, reproductive, and metabolic dysfunctional features. Obesity and PCOS often coexist. Insulin resistance and subsequent hyperinsulinemia are key factors implicated in the clinico-pathological manifestations of PCOS and associated metabolic syndrome. Obesity may amplify these effects, thus, affecting adolescent girls and women of childbearing age. Evidence supports weight loss in achieving favourable endocrine, metabolic, and reproductive outcomes in women with Polycystic Ovary Syndrome and coexisting obesity. Therefore, an effective weight loss strategy should be considered as a front-line interven-tion in this patient population, with emphasis on fertility timeline-related management in reproductive-aged women, where applicable. This brief narrative review provides insight into the impact of obesity and weight loss on women with Polycystic Ovary Syndrome and coexisting obesity.
C1 [Ghafoor, Saadia] Cure Med Facil Obstet & Gynecol, Peshawar, Pakistan.
   [Ghafoor, Saadia] Cure Med Facil, Peshawar 25000, Pakistan.
RP Ghafoor, S (corresponding author), Cure Med Facil, Peshawar 25000, Pakistan.
EM drsaadiag@gmail.com
RI Ghafoor, Saadia/AAE-4855-2021
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NR 103
TC 0
Z9 0
U1 0
U2 5
PU APROFEMA SRO
PI PRAGUE
PA U TRATI 3257-1C, PRAGUE, 100 00, CZECH REPUBLIC
SN 1803-9588
J9 AKTUALNI GYNEKOL POR
JI Aktualni Gynekol. Porod.
PY 2023
VL 15
BP 21
EP 31
PG 11
WC Obstetrics & Gynecology
WE Emerging Sources Citation Index (ESCI)
SC Obstetrics & Gynecology
GA C4ZB7
UT WOS:000962003100001
DA 2025-06-11
ER

PT J
AU Davis, DW
   Navalta, JW
   McGinnis, GR
   Serafica, R
   Izuora, K
   Basu, A
AF Davis, Dustin W.
   Navalta, James W.
   McGinnis, Graham R.
   Serafica, Reimund
   Izuora, Kenneth
   Basu, Arpita
TI Effects of Acute Dietary Polyphenols and Post-Meal Physical Activity on
   Postprandial Metabolism in Adults with Features of the Metabolic
   Syndrome
SO NUTRIENTS
LA English
DT Review
DE overweight; obesity; dysglycemia; dyslipidemia; oxidative damage;
   inflammation; exercise; oils; fruits; teas; legumes
ID TRIGLYCERIDE-RICH LIPOPROTEINS; HIGH-FAT MEAL; CARDIOVASCULAR-DISEASE;
   SKELETAL-MUSCLE; GLUCOSE-TRANSPORT; INSULIN-RESISTANCE; BLOOD-GLUCOSE;
   ANTIOXIDANT CAPACITY; OXIDATIVE STRESS; GLYCEMIC CONTROL
AB Approximately 22% of U.S. adults and 25% of adults globally have metabolic syndrome (MetS). Key features, such as dysglycemia and dyslipidemia, predict type 2 diabetes, cardiovascular disease, premature disability, and death. Acute supplementation of dietary polyphenols and post-meal physical activity hold promise in improving postprandial dysmetabolism. To our knowledge, no published review has described the effects of either intervention on postprandial glucose, insulin, lipids, and markers of oxidative damage and inflammation in adults with features of MetS. Thus, we conducted this review of controlled clinical trials that provided dietary polyphenols from oils, fruits, teas, and legumes during a dietary challenge, or implemented walking, cycling, and stair climbing and descending after a dietary challenge. Clinical trials were identified using ClinicalTrials.gov, PubMed, and Google Scholar and were published between 2000 and 2019. Dietary polyphenols from extra virgin olive oil, grapes, blackcurrants, strawberries, black tea, and black beans improved postprandial glucose, insulin, and markers of oxidative damage and inflammation, but results were not consistent among clinical trials. Freeze-dried strawberry powder distinctly improved postprandial insulin and markers of oxidative damage and inflammation. Post-meal physical activity attenuated postprandial glucose, but effects on postprandial lipids and markers of oxidative damage and inflammation were inconclusive. Consuming dietary polyphenols with a meal and completing physical activity after a meal may mitigate postprandial dysmetabolism in adults with features of MetS.
C1 [Davis, Dustin W.; Navalta, James W.; McGinnis, Graham R.; Basu, Arpita] Univ Nevada, Dept Kinesiol & Nutr Sci, Sch Integrated Hlth Sci, Las Vegas, NV 89154 USA.
   [Serafica, Reimund] Univ Nevada, Sch Nursing, Las Vegas, NV 89154 USA.
   [Izuora, Kenneth] Univ Nevada, Sch Med, Dept Internal Med, Las Vegas, NV 89154 USA.
C3 Nevada System of Higher Education (NSHE); University of Nevada Las
   Vegas; Nevada System of Higher Education (NSHE); University of Nevada
   Las Vegas; Nevada System of Higher Education (NSHE); University of
   Nevada Las Vegas
RP Basu, A (corresponding author), Univ Nevada, Dept Kinesiol & Nutr Sci, Sch Integrated Hlth Sci, Las Vegas, NV 89154 USA.
EM dustin.davis@unlv.edu; james.navalta@unlv.edu; graham.mcginnis@unlv.edu;
   reimund.serafica@unlv.edu; kenneth.izuora@unlv.edu; arpita.basu@unlv.edu
RI Serafica, Reimund/Q-5439-2019; Navalta, James/H-6626-2019
OI McGinnis, Graham/0000-0001-6185-6505; Navalta,
   James/0000-0002-4445-7614; Izuora, Kenneth/0000-0001-7171-3073; Davis,
   Dustin/0000-0001-5894-3851
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NR 105
TC 11
Z9 11
U1 2
U2 19
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD APR
PY 2020
VL 12
IS 4
AR 1120
DI 10.3390/nu12041120
PG 24
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA LL8VE
UT WOS:000531831300240
PM 32316418
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Sousa, GJ
   Oliveira, PWC
   Nogueira, BV
   Melo, AF
   Faria, TD
   Meira, EF
   Mill, JG
   Bissoli, NS
   Baldo, MP
AF Sousa, Glauciene J.
   Oliveira, Phablo Wendell C.
   Nogueira, Breno V.
   Melo Junior, Antonio F.
   Faria, Thais de Oliveira
   Meira, Eduardo Frizera
   Mill, Jose G.
   Bissoli, Nazare S.
   Baldo, Marcelo P.
TI Fructose intake exacerbates the contractile response elicited by
   norepinephrine in mesenteric vascular bed of rats via increased
   endothelial prostanoids
SO JOURNAL OF NUTRITIONAL BIOCHEMISTRY
LA English
DT Article
DE Fructose; Metabolic syndrome; Vascular function; Endothelial
   prostanoids; Mesenteric vascular bed
ID INSULIN-RESISTANCE; OXIDATIVE STRESS; BLOOD-PRESSURE; CORN SYRUP;
   REACTIVITY; BEVERAGES; LOSARTAN; DYSFUNCTION; OBESITY; RISK
AB Chronic fructose intake induces major cardiovascular and metabolic disturbances and is associated with the development of hypertension due to changes in vascular function. We hypothesized that high fructose intake for 6 weeks would cause metabolic syndrome and lead to initial vascular dysfunction. Male Wistar rats were assigned to receive fructose (FRU, 10%) or drinking water (CON) for 6 weeks. Systolic blood pressure was evaluated by tail plethysmography. Fasting glucose, insulin and glucose tolerance were measured at the end of the follow-up. Mesenteric vascular bed reactivity was tested before and after pharmacological blockade. Western blot analysis was performed for iNOS, eNOS, Nox2 and COX-2. DHE staining was used for vascular superoxide anion detection. Vessel structure was evaluated by optical and electronic microscopy.
   Fructose intake did not alter blood pressure, but did increase visceral fat deposition and fasting glucose as well as impair insulin and glucose tolerance. Fructose increased NE-induced vasoconstriction compared with CON, and this difference was abrogated by indomethacin perfusion as well as endothelium removal. ACh-induced relaxation was preserved, and the NO modulation tested after L-NAME perfusion was similar between groups. SNP-induced relaxation was not altered. Inducible NOS was increased; however, there were no changes in eNOS, Nox2 or COX-2 protein expression. Basal or stimulated superoxide anion production was not changed by fructose intake. In conclusion, high fructose intake increased NE-induced vasoconstriction through the endothelial prostanoids even in the presence of a preserved endothelium-mediated relaxation. No major changes in vessel structure were detected. (C) 2017 Elsevier Inc. All rights reserved.
C1 [Sousa, Glauciene J.; Oliveira, Phablo Wendell C.; Melo Junior, Antonio F.; Meira, Eduardo Frizera; Mill, Jose G.; Bissoli, Nazare S.] Univ Fed Espirito Santo, Dept Physiol Sci, Vitoria, Brazil.
   [Nogueira, Breno V.] Univ Fed Espirito Santo, Dept Morphol, Vitoria, ES, Brazil.
   [Faria, Thais de Oliveira; Baldo, Marcelo P.] Montes Claros State Univ, Dept Pathophysiol, Montes Claros, Brazil.
   [Meira, Eduardo Frizera] Univ Fed Espirito Santo, Dept Pharm & Nutr, Alegre, Brazil.
C3 Universidade Federal do Espirito Santo; Universidade Federal do Espirito
   Santo; Universidade Estadual de Montes Claros; Universidade Federal do
   Espirito Santo
RP Baldo, MP (corresponding author), Montes Claros State Univ, Dept Pathophysiol, UNIMONTES, Av Rui Braga,Vila Mauriceia, BR-39401089 Montes Claros, MG, Brazil.
EM marcelobaldo@ymail.com
RI Bissoli, Nazare/ABA-2679-2021; Ferreira de Melo Junior,
   Antonio/LIG-3474-2024; Meira, Eduardo/IVV-7442-2023; Baldo,
   Marcelo/G-6994-2012; O, P/AAV-8148-2020; NOGUEIRA, BRENO/O-7459-2016
OI NOGUEIRA, BRENO/0000-0002-2199-0635; /0000-0002-3264-3284; Baldo,
   Marcelo/0000-0002-7673-3580; Ferreira de Melo Junior,
   Antonio/0000-0001-6831-1823; Meira, Eduardo Frizzera/0000-0002-0210-4319
FU Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
   [445519/2014-2, 304147/2016-8, 457897/2014-7]; Fundacao de Amparo a
   Pesquisa do Estado de Minas Gerais (FAPEMIG) [CBB - BIP-00034-16];
   Fundacao de Amparo a Pesquisa do Estado do Espirito Santo (FAPES)
   [Universal FAPES] [67644562/15, 033/2016]
FX This work was supported by grants from Conselho Nacional de
   Desenvolvimento Cientifico e Tecnologico (CNPq) [#445519/2014-2;
   #304147/2016-8; #457897/2014-7], Fundacao de Amparo a Pesquisa do Estado
   de Minas Gerais (FAPEMIG) [CBB - BIP-00034-16] and Fundacao de Amparo a
   Pesquisa do Estado do Espirito Santo (FAPES) [Universal FAPES
   #67644562/15; #033/2016]. These funding agencies had no involvement in
   the study design, data collection, analysis and interpretation of data;
   in the writing of the report; and in the decision to submit the article
   for publication.
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NR 39
TC 7
Z9 7
U1 0
U2 4
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0955-2863
EI 1873-4847
J9 J NUTR BIOCHEM
JI J. Nutr. Biochem.
PD OCT
PY 2017
VL 48
BP 21
EP 28
DI 10.1016/j.jnutbio.2017.06.005
PG 8
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA FJ4MU
UT WOS:000412715200003
PM 28654829
DA 2025-06-11
ER

PT J
AU Kurata, T
   Lukic, V
   Kozuki, M
   Wada, D
   Miyazaki, K
   Morimoto, N
   Ohta, Y
   Deguchi, K
   Ikeda, Y
   Kamiya, T
   Abe, K
AF Kurata, Tomoko
   Lukic, Violeta
   Kozuki, Miki
   Wada, Daisuke
   Miyazaki, Kazunori
   Morimoto, Nobutoshi
   Ohta, Yasuyuki
   Deguchi, Kentaro
   Ikeda, Yoshio
   Kamiya, Tatsushi
   Abe, Koji
TI Telmisartan Reduces Progressive Accumulation of Cellular Amyloid Beta
   and Phosphorylated Tau with Inflammatory Responses in Aged Spontaneously
   Hypertensive Stroke Resistant Rat
SO JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
LA English
DT Article
DE Alzheimer's disease; spontaneously hypertensive rat; telmisartan;
   inflammation
ID ANGIOTENSIN-II; RECEPTOR ANTAGONIST; VASCULAR DEMENTIA; COGNITIVE
   DECLINE; OXIDATIVE STRESS; TRUNCATED TAU; MOUSE MODEL; PROTEIN;
   HIPPOCAMPUS; CANDESARTAN
AB Background: In addition to reducing the level of blood pressure (BP), telmisartan was expected to show the long-term neuroprotective effects preventing accumulation of cellular amyloid beta peptide (Ab) and phosphorylated tau (p tau) by ameliorating neuroinflammation. Methods: We examined effects of telmisartan on cellular Ab and pt with inflammatory responses in the brain of a spontaneously hypertensive stroke resistant (SHR-SR) rat by giving either telmisartan at 0 (vehicle), .3 mg/kg/day or 3 mg/kg/day, orally, from 3 months of age and performed immunohistologic analysis at 6, 12, and 18 months. Compared with normotensive Wistar rats, numbers of Ab-and pt-positive neurons in the cerebral cortex progressively increased with age until 18 months in the SHR-SR rats, as did the numbers of ionized calcium-binding adapter molecule 1 (Iba-1)-positive microglia, tumor necrosis factor alpha (TNF-alpha)-positive neurons, and monocyte chemotactic protein 1 (MCP-1)-positive neurons. Results: Low-dose telmisartan significantly decreased the numbers of A beta-and p tau-positive neuron as well as the numbers of TNF-alpha-positive neurons, Iba-1-positive microglia, and MCP-1-positive neurons at 6, 12, and 18 months. High-dose telmisartan reduced BP and showed a further reduction of cellular A beta and p tau. Conclusions: The present study suggests that accumulation of cellular A beta and p tau and the inflammatory responses were decreased via improving metabolic syndrome with low-dose telmisartan and improving both metabolic syndrome and hypertension with high-dose telmisartan.
C1 [Kurata, Tomoko; Lukic, Violeta; Kozuki, Miki; Wada, Daisuke; Miyazaki, Kazunori; Morimoto, Nobutoshi; Ohta, Yasuyuki; Deguchi, Kentaro; Ikeda, Yoshio; Kamiya, Tatsushi; Abe, Koji] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Neurol, Okayama 7008558, Japan.
C3 Okayama University
RP Abe, K (corresponding author), Okayama Univ, Grad Sch Med Dent & Pharm, Dept Neurol, 2-5-1 Shikata Cho, Okayama 7008558, Japan.
EM toko11@cc.okayama-u.ac.jp
FU Research Committee of CNS Degenerative Diseases [21390267]; Ministry of
   Education, Culture, Sports, Science, and Technology of Japan; Ministry
   of Health, Labour and Welfare of Japan
FX This work was partly supported by a Grant-in-Aid for Scientific Research
   (B) 21390267 from the Research Committee of CNS Degenerative Diseases;
   the Ministry of Education, Culture, Sports, Science, and Technology of
   Japan, and by Grants-in-Aid from Aoki M, Matsuoka Y, Mizusawa H, Nakano
   I, Nishizawa M, and Sasaki H from the Ministry of Health, Labour and
   Welfare of Japan.
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NR 45
TC 35
Z9 38
U1 0
U2 18
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1052-3057
EI 1532-8511
J9 J STROKE CEREBROVASC
JI J. Stroke Cerebrovasc. Dis.
PD NOV-DEC
PY 2014
VL 23
IS 10
BP 2580
EP 2590
DI 10.1016/j.jstrokecerebrovasdis.2014.05.023
PG 11
WC Neurosciences; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Cardiovascular System & Cardiology
GA AU5ME
UT WOS:000345650300027
PM 25241340
DA 2025-06-11
ER

PT J
AU Katsiki, N
   Mikhailidis, DP
   Nair, DR
AF Katsiki, Niki
   Mikhailidis, Dimitri P.
   Nair, Devaki R.
TI The effects of antiepileptic drugs on vascular risk factors: A narrative
   review
SO SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
LA English
DT Review
DE Vascular disease; Epilepsy treatment; Cholesterol; Homocysteine; Risk
ID SUDDEN UNEXPECTED DEATH; C-REACTIVE PROTEIN; URIC-ACID LEVELS; POTENTIAL
   THERAPEUTIC TARGET; CORONARY-HEART-DISEASE; LONG-TERM EXPERIENCE;
   VALPROIC ACID; EPILEPTIC PATIENTS; METABOLIC SYNDROME; OXIDATIVE STRESS
AB Purpose: Epilepsy is associated with increased cardiovascular disease (CVD) morbidity and mortality. The exact causes of this link are not clearly defined. The role of antiepileptic drugs (AEDs) in influencing CVD risk in patients with epilepsy remains controversial. A link between epilepsy, AEDs and cardiac arrhythmias has been proposed and may be responsible for sudden unexpected death in epilepsy (SUDEP).
   Methods: We searched MEDLINE up to December 1, 2013 for relevant publications using combinations of keywords. We also examined the reference list of articles identified by this search and selected those we judged relevant. These were included in this narrative review.
   Results: AEDs may exert both beneficial and adverse cardiovascular effects. This narrative review considers the influence of AEDs on some predictors of vascular risk [i.e. weight, insulin resistance, metabolic syndrome, lipids, lipoprotein (a), C-reactive protein, homocysteine, vitamins, coagulation factors, uric acid, carotid intima media thickness, markers of oxidative status and matrix metalloproteinase-9]. Certain AEDs can also have pro-arrhythmic properties.
   Conclusions: AEDs may exert different effects on various established and emerging predictors of vascular risk. Furthermore, pharmacokinetic interactions between AEDs and drugs used to reduce vascular risk (e.g. statins) need to be better documented. Whether this knowledge, in terms of individualizing antiepileptic and CVD prevention treatment, will prove to be relevant in clinical practice remains to be established. (c) 2014 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.
C1 [Katsiki, Niki; Mikhailidis, Dimitri P.] UCL, Sch Med, Vasc Dis Prevent Clin, Dept Clin Biochem, London NW3 2QG, England.
   [Katsiki, Niki] Aristotle Univ Thessaloniki, Hippokrat Hosp, Propedeut Dept Internal Med 2, Sch Med, GR-54006 Thessaloniki, Greece.
   [Nair, Devaki R.] Royal Free Hosp, Dept Clin Biochem, Vasc Dis Prevent Clin, London NW3 2QG, England.
C3 University of London; University College London; UCL Medical School;
   Aristotle University of Thessaloniki; University of London; University
   College London; Royal Free London NHS Foundation Trust; UCL Medical
   School
RP Nair, DR (corresponding author), Royal Free Hosp, Dept Clin Biochem, Vasc Dis Prevent Clin, Pond St, London NW3 2QG, England.
EM devaki.nair@nhs.net
RI Mikhailidis, Dimitri/A-1869-2013; KATSIKI, NIKI/ADE-7999-2022
OI KATSIKI, NIKI/0000-0003-0894-2644
FU MSD; Solvay (Abbott); Pfizer
FX This review was written independently; no company or institution
   supported it financially. Dr N. Katsiki has given talks and attended
   conferences sponsored by Novartis, Pfizer, MSD and Astra Zeneca. Dr
   Mikhailidis has given talks and attended conferences sponsored by Merck
   Sharpe, Dohme and Genzyme. Dr Nair has received unrestricted educational
   grants by MSD, Solvay (Abbott) and Pfizer, has given talks and
   participated in advisory boards sponsored by MSD, Solvay, Abbott and
   Astra Zeneca.
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NR 160
TC 71
Z9 73
U1 0
U2 19
PU W B SAUNDERS CO LTD
PI LONDON
PA 32 JAMESTOWN RD, LONDON NW1 7BY, ENGLAND
SN 1059-1311
EI 1532-2688
J9 SEIZURE-EUR J EPILEP
JI Seizure
PD OCT
PY 2014
VL 23
IS 9
BP 677
EP 684
DI 10.1016/j.seizure.2014.05.011
PG 8
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA AR8QH
UT WOS:000343839200001
PM 25028247
OA Bronze
DA 2025-06-11
ER

PT J
AU Shimano, H
AF Shimano, Hitoshi
TI Novel qualitative aspects of tissue fatty acids related to metabolic
   regulation: Lessons from Elovl6 knockout
SO PROGRESS IN LIPID RESEARCH
LA English
DT Review
ID STEAROYL-COA DESATURASE-1; HEPATIC INSULIN-RESISTANCE; PANCREATIC
   BETA-CELLS; BINDING PROTEINS; LIVER-DISEASE; PROTECTS MICE; OBESITY;
   ELONGASE; SECRETION; OXIDATION
AB Insulin resistance, often associated with obesity, precipitates metabolic syndrome, type 2 diabetes, and finally, atherosclerosis. Sources of excess energy cause abnormal accumulation of tissue lipids leading to cellular dysfunction through cellular stress and inflammation. This process is often referred to as lipotoxicity. Until date, effective approaches that aim to overcome insulin resistance involve amelioration of obesity by caloric restriction and/or exercise. Quantitative control of lipids, especially triglycerides and fatty acids in adipose and other tissues, and plasma can be addressed using these measures. However, altering tissue lipid composition may provide another strategy to prevent or control lipotoxicity. Endogenous fatty acid synthesis plays a crucial role in determining tissue energy states. As a target gene of SREBP-1 that controls lipogenesis we identified a unique enzyme, Elovl6, which is responsible for the final step in endogenous saturated fatty acid synthesis, thereby controlling tissue fatty acid composition. Elovl6-deficient mice become obese and develop hepatosteatosis when fed a high-fat diet or when mated to leptin-deficient ab/ab mice. However, the mice exhibited marked protection from hyperinsulinemia, hyperglycemia, and hyperleptinemia. Hepatic fatty acid composition is a novel determinant of insulin sensitivity independent of cellular energy balance. Inhibiting Elovl6 activity may provide a novel therapeutic approach for treating insulin resistance, diabetes, metabolic syndrome, and cardiovascular risks by circumventing obesity problems. In this review, we consider fatty acid metabolism and lipotoxicity, and discuss the role of Elovl6 in newly recognized aspects of metabolic regulation. (C) 2012 Published by Elsevier Ltd.
C1 Univ Tsukuba, Grad Sch Comprehens Human Sci, Dept Internal Med Endocrinol & Metab, Tsukuba, Ibaraki 3058575, Japan.
C3 University of Tsukuba
RP Shimano, H (corresponding author), Univ Tsukuba, Grad Sch Comprehens Human Sci, Dept Internal Med Endocrinol & Metab, 1-1-1 Tennodai, Tsukuba, Ibaraki 3058575, Japan.
EM hshimano@md.tsukuba.ac.jp
RI Shimano, Hitoshi/V-1761-2019
OI Shimano, Hitoshi/0000-0002-5562-5572
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NR 33
TC 43
Z9 48
U1 0
U2 32
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0163-7827
J9 PROG LIPID RES
JI Prog. Lipid Res.
PD JUL
PY 2012
VL 51
IS 3
BP 267
EP 271
DI 10.1016/j.plipres.2011.12.004
PG 5
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA 965ME
UT WOS:000305771100007
PM 22266797
DA 2025-06-11
ER

PT J
AU Pagadala, MR
   Zein, CO
   Dasarathy, S
   Yerian, LM
   Lopez, R
   McCullough, AJ
AF Pagadala, Mangesh R.
   Zein, Claudia O.
   Dasarathy, Srinivasan
   Yerian, Lisa M.
   Lopez, Rocio
   McCullough, Arthur J.
TI Prevalence of Hypothyroidism in Nonalcoholic Fatty Liver Disease
SO DIGESTIVE DISEASES AND SCIENCES
LA English
DT Article
DE Fatty liver; Nonalcoholic steatohepatitis; Hypothyroidism; Insulin
   resistance
ID MODERATE ALCOHOL INTAKE; THYROID-DYSFUNCTION; HEPATIC STEATOSIS;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; OXIDATIVE STRESS;
   NATIONAL-HEALTH; UNITED-STATES; RISK-FACTORS; ASSOCIATION
AB A possible association between nonalcoholic fatty liver disease (NAFLD) and hypothyroidism has been suggested. The recognized link between hypothyroidism and elements of the metabolic syndrome may explain this association.
   The purpose of this study was to determine the prevalence of hypothyroidism in a cohort of patients with NAFLD and analyze the potential factors associated with hypothyroidism in this patient population.
   Two hundred forty-six patients with biopsy-proven NAFLD attending hepatology clinics at the Cleveland Clinic between October 2006 and June 2009, and 430 age-, gender-, race- and BMI-matched control subjects seen in the general internal medicine clinic were included. Patients with a clinical diagnosis of hypothyroidism who were on thyroid replacement therapy were considered to be hypothyroid.
   Hypothyroidism was more frequent among patients with NAFLD (21% vs. 9.5%; P < 0.01) compared to controls, and was higher in NASH patients than NAFLD patients without NASH (25% vs. 12.8%, P = 0.03). Subjects with hypothyroidism were 2.1 (95% CI 1.1-3.9, P = 0.02) and 3.8 (95% CI 2-6.9, P < 0.001) times more likely to have NAFLD and NASH, respectively. By multivariate analysis, female gender (P < 0.001) and increased BMI (P = 0.03) were associated with hypothyroidism. NAFLD subjects who reported mild alcohol consumption were less likely to have hypothyroidism compared to those who reported complete abstinence (OR 0.37, P = 0.008).
   A higher prevalence of hypothyroidism was demonstrated in patients with NAFLD compared to controls. Among subjects with NALFD, female gender, increased BMI and history of abstinence from alcohol were associated with hypothyroidism. Patients with hypothyroidism were also more likely to have NASH.
C1 [Pagadala, Mangesh R.; Dasarathy, Srinivasan; McCullough, Arthur J.] Cleveland Clin Fdn, Dept Gastroenterol & Hepatol, Cleveland, OH 44195 USA.
   [Zein, Claudia O.; McCullough, Arthur J.] Case Western Reserve Univ, Cleveland Clin, Lerner Coll Med, Dept Gastroenterol, Cleveland, OH 44195 USA.
   [Yerian, Lisa M.] Cleveland Clin, Dept Anat Pathol, Cleveland, OH 44106 USA.
C3 Cleveland Clinic Foundation; Cleveland Clinic Foundation; University
   System of Ohio; Case Western Reserve University; Cleveland Clinic
   Foundation
RP McCullough, AJ (corresponding author), Cleveland Clin Fdn, Dept Gastroenterol & Hepatol, 9500 Euclid Ave,A30, Cleveland, OH 44195 USA.
EM MCCULLA@ccf.org
RI Pagadala, Mangesh/AAP-2760-2020
OI Lopez Moscoso, Ana Rocio/0000-0002-4319-420X
FU National Center for Research Resources (NCRR), National Institutes of
   Health (NIH) [KL2 RR024990]; NIH Roadmap for Medical Research; NIH [5
   U01 DK 061732];  [T32 DK061917];  [DK 061732]
FX Claudia O. Zein was supported by Grant Number KL2 RR024990 from the
   National Center for Research Resources (NCRR), a component of the
   National Institutes of Health (NIH), and NIH Roadmap for Medical
   Research. Mangesh R. Pagadala was supported by the grant number T32
   DK061917 and DK 061732. Arthur J. McCullough was supported in part by
   NIH grant 5 U01 DK 061732.
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NR 52
TC 134
Z9 147
U1 2
U2 11
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0163-2116
EI 1573-2568
J9 DIGEST DIS SCI
JI Dig. Dis. Sci.
PD FEB
PY 2012
VL 57
IS 2
BP 528
EP 534
DI 10.1007/s10620-011-2006-2
PG 7
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 881LS
UT WOS:000299487500038
PM 22183820
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Enjoji, M
   Kotoh, K
   Kato, M
   Higuchi, N
   Kohjima, M
   Nakashima, M
   Nakamuta, M
AF Enjoji, Munechika
   Kotoh, Kazuhiro
   Kato, Masaki
   Higuchi, Nobito
   Kohjima, Motoyuki
   Nakashima, Manabu
   Nakamuta, Makoto
TI Therapeutic effect of ARBs on insulin resistance and liver injury in
   patients with NAFLD and chronic hepatitis C: A pilot study
SO INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
LA English
DT Article
DE insulin resistance; angiotensin II receptor blocker; chronic hepatitis
   C; non-alcoholic fatty liver disease
ID ANGIOTENSIN RECEPTOR BLOCKERS; METABOLIC SYNDROME; OXIDATIVE STRESS;
   HYPERTENSIVE PATIENTS; DISEASE; TELMISARTAN; VALSARTAN; BLOCKADE;
   STEATOHEPATITIS; PIOGLITAZONE
AB Fatty liver is one of the local morphological manifestations of metabolic syndrome and is frequently associated with insulin resistance. Insulin resistance is also common in patients with chronic hepatitis C. Hyperinsulinemia is an independent risk factor for hypertension and cardiovascular mortality. The aim of this study was to evaluate the therapeutic efficacy of angiotensin II receptor blockers (ARBs), telmisartan and olmesartan, for patients with nonalcoholic fatty liver disease (NAFLD) and chronic hepatitis C (CH-C). We analyzed the incidence of obesity, insulin resistance, and other disorders in patients with NAFLD (Group A), CH-C (Group B), or other liver diseases (Group Q. We evaluated whether the ARBs, telmisartan and olmesartan, improved insulin resistance and liver injury by measuring the homeostasis model assessment ratio of insulin resistance (HOMA-IR) and serum alanine aminotransferase (ALT). The incidence of obesity (BMI >= 25 kg/m(2)) was significantly higher in Group A than in Groups B and C. The incidence of insulin resistance (HOMA-IR >= 2.5) in Groups A and B was significantly higher than in Group C. Regular doses of telmisartan and olmesartan significantly improved HOMA-IR and ALT levels not only in NAFLD patients but also in patients with CH-C. The effects tended to be more notable with telmisartan. In conclusion, telmisartan and olmesartan improved insulin sensitivity and may possibly be used as liver protecting agents in CH-C as well as NAFLD patients.
C1 [Enjoji, Munechika; Nakashima, Manabu] Fukuoka Univ, Fac Pharmaceut Sci, Dept Clin Pharmacol, Johnan Ku, Fukuoka 8140180, Japan.
   [Enjoji, Munechika; Kotoh, Kazuhiro; Kato, Masaki; Higuchi, Nobito; Kohjima, Motoyuki] Kyushu Univ, Dept Med & Bioregulatory Sci, Grad Sch Med Sci, Fukuoka 812, Japan.
   [Nakamuta, Makoto] Natl Hosp Org Kyushu Med Ctr, Dept Gastroenterol, Fukuoka, Japan.
C3 Fukuoka University; Kyushu University
RP Enjoji, M (corresponding author), Fukuoka Univ, Fac Pharmaceut Sci, Dept Clin Pharmacol, Johnan Ku, 8-19-1 Nanakuma, Fukuoka 8140180, Japan.
EM enjoji@adm.fukuoka-u.ac.jp
RI Enjoji, Munechika/F-1881-2010
FU Daiwa Securities Health Foundation (Japan)
FX This study was supported, in part, by the research fund of the Daiwa
   Securities Health Foundation (Japan).
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NR 48
TC 38
Z9 41
U1 0
U2 0
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1107-3756
EI 1791-244X
J9 INT J MOL MED
JI Int. J. Mol. Med.
PD OCT
PY 2008
VL 22
IS 4
BP 521
EP 527
DI 10.3892/ijmm_00000051
PG 7
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 356FG
UT WOS:000259763500016
PM 18813860
OA Bronze
DA 2025-06-11
ER

PT J
AU Roglans, N
   Vilà, L
   Farré, M
   Alegret, M
   Sánchez, RM
   Váquez-Carrera, M
   Laguna, JC
AF Roglans, Nuria
   Vila, Laia
   Farre, Mireia
   Alegret, Marta
   Maria Sanchez, Rosa
   Vaquez-Carrera, Manuel
   Carlos Laguna, Juan
TI Impairment of hepatic STAT-3 activation and reduction of PPARα activity
   in fructose-fed rats
SO HEPATOLOGY
LA English
DT Article
ID KAPPA-B ACTIVATION; RECEPTOR-ALPHA; CARBOHYDRATE-METABOLISM;
   TRANSCRIPTION FACTOR; OXIDATIVE STRESS; EXPRESSION; INSULIN; GENE; MICE;
   HYPERTRIGLYCERIDEMIA
AB Fructose makes up a significant proportion of energy intake in westernized diets, its increased consumption has paralleled the growing prevalence of obesity and metabolic syndrome over the past two decades. In the current study, we demonstrate that fructose administration (10% wt/vol) in the drinking water of rats reduces the trans-activating and trans-repressing activity of the hepatic peroxisome proliferator-activated receptor alpha (PPAR alpha). As a consequence, fructose decreases hepatic fatty oxidation and increases pro-inflammatory transcription factor nuclear factor kappa B (NF-kappa B) activity. These changes were not observed in glucose-administered rats (10% wt/vol), although both carbohydrates produced similar changes in plasma adiponectin and in the hepatic expression of transcription factors and enzymes involved in fatty acid synthesis. Fructosefed, but not glucose-fed, rats were hyperleptinemic and exhibited increased tyrosine phosphorylation of the signal transducer and activator of transcription-3 (STAT-3) transcription factor, although they did not present a similar increase in the serine phosphorylation of nuclear STAT3. Thus, an impairment in the hepatic transduction of the leptin signal could be responsible for the observed alterations in PPARa activity in fructose-fed rats. Because PPARa activity is lower in human than in rodent liver, fructose ingestion in humans should cause even worse effects, which would partly explain the link between increased consumption of fructose and widening epidemics of obesity and metabolic syndrome. Conclusion: Hypertriglyceridemia and hepatic steatosis induced by fructose ingestion result from a reduction in the hepatic catabolism of fatty acids driven by a state of leptin resistance.
C1 Univ Barcelona, Sch Pharm, Dept Pharmacol & Therapeut Chem, E-08028 Barcelona, Spain.
   IBUB, Barcelona, Spain.
C3 University of Barcelona; University of Barcelona
RP Laguna, JC (corresponding author), Univ Barcelona, Sch Pharm, Dept Pharmacol & Therapeut Chem, E-08028 Barcelona, Spain.
EM jclagunae@ub.edu
RI Roglans, Núria/ABH-1242-2020; Vilà, Laia/ABG-8595-2020; Laguna, Juan
   C/C-5481-2017; Alegret, Marta/C-5086-2017; Vazquez-Carrera,
   Manuel/H-2612-2015
OI Vila, Laia/0000-0001-7232-2250; Laguna, Juan C/0000-0002-7082-0704;
   Alegret, Marta/0000-0002-5652-8651; Roglans, Nuria/0000-0002-5018-021X;
   Vazquez-Carrera, Manuel/0000-0001-7138-8207
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NR 47
TC 185
Z9 203
U1 1
U2 27
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0270-9139
EI 1527-3350
J9 HEPATOLOGY
JI Hepatology
PD MAR
PY 2007
VL 45
IS 3
BP 778
EP 788
DI 10.1002/hep.21499
PG 11
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 144KJ
UT WOS:000244794600025
PM 17326204
DA 2025-06-11
ER

PT J
AU Mohatt, GV
   Plaetke, R
   Klejka, J
   Luick, B
   Lardon, C
   Bersamin, A
   Hopkins, S
   Dondanville, M
   Herron, J
   Boyer, B
AF Mohatt, Gerald V.
   Plaetke, Rosemarie
   Klejka, Joseph
   Luick, Bret
   Lardon, Cecile
   Bersamin, Andrea
   Hopkins, Scarlett
   Dondanville, Michelle
   Herron, Johanna
   Boyer, Bert
CA CANHR Res Team
TI The center for Alaska Native Health Research study: A community-based
   participatory research study of obesity and chronic disease-related
   protective and risk factors
SO INTERNATIONAL JOURNAL OF CIRCUMPOLAR HEALTH
LA English
DT Article
DE Alaska Native health; health disparities; obesity; diabetes; metabolic
   syndrome; Yup'ik Eskimo
ID BERING STRAITS REGION; ESKIMOS
AB Objectives. To describe the background, approach and general results of the Center for Alaska Native Health Research (CANHR) study.
   Study Design. This was a cross-sectional Community-Based Participatory Research (CBPR) study with one tribal group to assess risk and protection for obesity and the risk factors related to chronic disease, diabetes and cardiovascular disease.
   Methods. A combination of biological, genetic, nutritional and psychosocial measurements were taken on 922 Alaska Native participants in ten communities in Southwestern Alaska. The paper reports on data from 753 adult participants.
   Results. The prevalence of type 2 diabetes is 3.3% in the sample population. Metabolic syndrome is significantly lower among the males and equal for females when compared with Caucasians in the NHANES III sample. Obesity among adults is now at the national average. Risk factors for chronic disease include a shift to a Westernized diet, stress, obesity and impaired fasting glucose and protective factors include high levels of polyunsaturated fatty acid dietary intake. Articles in this issue present specific results in these areas.
   Conclusions. The data strongly indicate that, in general, Yup'ik people in our study are metabolically healthy and that diet and life style provide a delicate combination of protective and risk factors. The results strongly indicate that solution focused research (1) utilizing primary and secondary prevention strategies may provide evidence for how to intervene to prevent further increases of chronic diseases. Research that focuses on relating the intrinsic strengths of indigenous worldviews and practices with basic research may contribute to positive transformations in community health.
C1 Univ Alaska Fairbanks, Ctr Alaska Nat Hlth Res, Fairbanks, AK 99775 USA.
   Yukon Kuskokwim Hlth Corp, Bethel, AK USA.
   Stanford Univ, Stanford, CA 94305 USA.
C3 University of Alaska System; University of Alaska Fairbanks; Stanford
   University
RP Mohatt, GV (corresponding author), Univ Alaska Fairbanks, Ctr Alaska Nat Hlth Res, POB 757000, Fairbanks, AK 99775 USA.
EM ffgvm@uaf.edu
FU NCRR NIH HHS [5 P20 RR016430] Funding Source: Medline
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   [Anonymous], 2005, IDF CONS WORLDW DEF
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NR 15
TC 80
Z9 95
U1 2
U2 20
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1239-9736
EI 2242-3982
J9 INT J CIRCUMPOL HEAL
JI Int. J. Circumpolar Health
PD FEB
PY 2007
VL 66
IS 1
BP 8
EP 18
DI 10.3402/ijch.v66i1.18219
PG 11
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA 147CN
UT WOS:000244981100004
PM 17451130
OA gold
DA 2025-06-11
ER

PT J
AU VandenAkker, NE
   Vendrame, S
   Tsakiroglou, P
   Klimis-Zacas, D
AF VandenAkker, Natalie E.
   Vendrame, Stefano
   Tsakiroglou, Panagiotis
   Klimis-Zacas, Dorothy
TI Red raspberry (Rubus idaeus) consumption restores the impaired
   vasoconstriction and vasorelaxation response in the aorta of the obese
   Zucker rat, a model of the Metabolic Syndrome
SO JOURNAL OF BERRY RESEARCH
LA English
DT Article
DE Endothelial dysfunction; obese Zucker rat; red raspberry;
   vasoconstriction; vasorelaxation; cyclooxygenase-2; nitric oxide;
   thromboxane A2; prostacyclin I2
ID NITRIC-OXIDE; RISK-FACTORS; ENDOTHELIAL DYSFUNCTION;
   VACCINIUM-ANGUSTIFOLIUM; PLATELET-AGGREGATION; VASCULAR FUNCTION; COX-2
   EXPRESSION; OXIDATIVE STRESS; DIABETIC FATTY; ATHEROSCLEROSIS
AB Metabolic Syndrome (MetS) increases the risk of cardiovascular disease. Whole red raspberry (WRR) consumption on vascular function was investigated in the obese Zucker rat (OZR), model of MetS. Male OZR and their lean littermates (LZR) were placed on a control (C) or an 8% w/w WRR-enriched diet for 8 weeks. Phenylephrine (Phe)-induced vasoconstriction and acetylcholine (Ach)-induced vasorelaxation were measured in aortic rings in the presence or absence of L-N-monomethyl-arginine (L-NMMA) and mefenamic acid (MFA). Phe-induced vasoconstriction was lower in the OZR-C compared to LZR-C (p < 0.05). The WRR diet partially restored aortic response in the OZR-WRR aorta (p < 0.05) compared to OZR-C. The OZR-WRR group pre-treated with L-NMMA increased compared to OZR-C (p < 0.05). Pre-treatment with L-NMMA, maximal relaxation response was higher in the OZR compared to the LZR (p < 0.05). With L-NMMA, maximal relaxation response in OZR-WRR (p < 0.05) was lower compared to the OZR-C. Prostacyclin I2 concentration was higher in the OZR compared to the LZR (p < 0.05) and was attenuated in the OZR-WRR (p < 0.05). Aortic expression of eNOS and COX-2 were downregulated in the OZR-WRR (p < 0.05). In conclusion, WRR restores the impaired vascular tone of the OZR by enhancing Phe-induced vasoconstriction and attenuating Ach-induced vasorelaxation.
C1 [VandenAkker, Natalie E.; Vendrame, Stefano; Tsakiroglou, Panagiotis; Klimis-Zacas, Dorothy] Univ Maine, Sch Food & Agr, Orono, ME 04469 USA.
C3 University of Maine System; University of Maine Orono
RP Klimis-Zacas, D (corresponding author), Univ Maine, Sch Food & Agr, Orono, ME 04469 USA.
EM dorothea@maine.edu
OI Tsakiroglou, Panagiotis/0000-0001-8823-9507
FU National Processed Raspberry Council; USDA National Institute of Food
   and Agriculture through the Maine Agricultural and Forest Experiment
   Station [ME0-31910, 3677]
FX This work was supported by the National Processed Raspberry Council.
   This project was also supported by the USDA National Institute of Food
   and Agriculture Hatch project number #ME0-31910 through the Maine
   Agricultural and Forest Experiment Station publication number 3677.
   Additionally, the red raspberry powder was generously provided by
   FutureCeuticals (Momence, IL).
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NR 62
TC 8
Z9 9
U1 0
U2 4
PU IOS PRESS
PI AMSTERDAM
PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS
SN 1878-5093
EI 1878-5123
J9 J BERRY RES
JI J. Berry Res.
PY 2021
VL 11
IS 1
BP 89
EP 101
DI 10.3233/JBR-200567
PG 13
WC Plant Sciences; Food Science & Technology; Horticulture; Nutrition &
   Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Food Science & Technology; Agriculture; Nutrition &
   Dietetics
GA QT7ND
UT WOS:000626775300006
DA 2025-06-11
ER

PT J
AU Kitagawa, A
   Ohta, Y
   Ohashi, K
   Yashiro, K
   Fukuzawa, K
AF Kitagawa, Akira
   Ohta, Yoshiji
   Ohashi, Koji
   Yashiro, Koji
   Fukuzawa, Kenji
TI Effect of High Fructose-Induced Metabolic Syndrome on Tissue Vitamin E
   and Lipid Peroxide Levels in Rats
SO JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY
LA English
DT Article
DE high fructose diet feeding; rat serum; rat tissues (liver, kidney,
   heart, skeletal muscle, and white adipose tissue); hyperinsulinemia;
   insulin resistance; dyslipidemia; hypertriglyceridemia;
   hypercholesterolemia; lipid peroxidation
ID OXIDATIVE STRESS; INSULIN SENSITIVITY; DEFENSE SYSTEM; ACID; TOCOPHEROL;
   PROTECTS; BLOOD; ASSAY
AB In the present study, we examined the effect of high fructose-induced metabolic syndrome (MetS) on tissue vitamin E and lipid peroxide (LPO) levels in rats. Feeding of a diet containing 60% fructose (HFD) to Wistar rats for 2, 4, and 6 wk caused week-dependent increases in HOMA-IR score and serum insulin, triglyceride, total cholesterol, and free fatty acid concentrations. Each week FWD feeding increased serum vitamin E concentration. Six-week HFD feeding reduced vitamin E status (the serum ratio of vitamin E/triglyceride+ total cholesterol). Four- and 6-wk HFD feeding increased serum LPO concentration. Two-week HFD feeding increased liver, heart, kidney, and skeletal muscle (SM) vitamin E contents and decreased white adipose tissue (WAT) vitamin E content. Four- and 6-wk HFD feeding further reduced WAT vitamin E content without affecting the increased kidney and SM vitamin E contents. Six-week HFD feeding reduced the increased liver and heart vitamin E contents below the level of non-HFD feeding. Four-week HFD feeding increased heart and WAT LPO contents. Six-week FWD feeding increased liver LPO content and further increased heart and WAT LPO contents. Kidney and SM LPO contents remained unchanged. These results indicate that HFD-rats with early MetS have increased liver, kidney, heart, and SM vitamin E contents and decreased WAT vitamin E content under unchanged tissue LPO content and vitamin E status, while HFD-fed rats with progressed MetS have both decreased liver, heart, and WAT vitamin E contents under increased tissue LPO content and disrupted vitamin E status.
C1 [Kitagawa, Akira] Shigakkan Univ, Fac Wellness, Dept Nutr, Obu, Aichi 4748651, Japan.
   [Ohta, Yoshiji; Yashiro, Koji] Fujita Hlth Univ, Dept Chem, Sch Med, Toyoake, Aichi 4701192, Japan.
   [Ohashi, Koji] Fujita Hlth Univ, Dept Biomed & Analyt Sci, Sch Med, Toyoake, Aichi 4701192, Japan.
   [Fukuzawa, Kenji] Yasuda Womens Univ, Dept Pharm, Fac Pharm, Asaminaini Ku, Hiroshima 7310153, Japan.
C3 Fujita Health University; Fujita Health University
RP Ohta, Y (corresponding author), Fujita Hlth Univ, Dept Chem, Sch Med, Toyoake, Aichi 4701192, Japan.
EM yohta@fujita-hu.ac.jp
RI Fukuzawa, Kaori/S-9485-2018
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NR 32
TC 10
Z9 10
U1 0
U2 2
PU CENTER ACADEMIC PUBL JAPAN
PI TOKYO
PA 2-4-16 YAYOI, BUNKYO-KU, TOKYO, 113-0032, JAPAN
SN 0301-4800
EI 1881-7742
J9 J NUTR SCI VITAMINOL
JI J. Nutr. Sci. Vitaminol.
PY 2020
VL 66
IS 2
BP 200
EP 206
DI 10.3177/jnsv.66.200
PG 7
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA MF4PP
UT WOS:000545326600014
PM 32350182
OA gold
DA 2025-06-11
ER

PT J
AU Magnoni, M
   Berteotti, M
   Ceriotti, F
   Mallia, V
   Vergani, V
   Peretto, G
   Angeloni, G
   Cristell, N
   Maseri, A
   Cianflone, D
AF Magnoni, Marco
   Berteotti, Martina
   Ceriotti, Ferruccio
   Mallia, Vincenzo
   Vergani, Vittoria
   Peretto, Giovanni
   Angeloni, Giulia
   Cristell, Nicole
   Maseri, Attilio
   Cianflone, Domenico
TI Serum uric acid on admission predicts in-hospital mortality in patients
   with acute coronary syndrome
SO INTERNATIONAL JOURNAL OF CARDIOLOGY
LA English
DT Article
DE Acute coronary syndrome; Uric acid; Biomarkers; Prognosis
ID ACUTE MYOCARDIAL-INFARCTION; C-REACTIVE PROTEIN; CARDIOVASCULAR-DISEASE;
   ESSENTIAL-HYPERTENSION; RISK-FACTOR; OXIDATIVE STRESS; PROGNOSTIC VALUE;
   HYPERURICEMIA; ASSOCIATION; ELEVATION
AB Background: Despite the association between uric acid and cardiovascular disease has been known for decades, the prognostic value of serum uric acid (UA) in all clinical manifestations of acute coronary syndrome (ACS), namely ST-elevation myocardial infarction (STEMI), NSTEMI and unstable angina, has not been definitively assessed.
   Methods: This retrospective analysis included patients from previous SPAI and FAMI studies with the aim to investigate the association between serum uric acid and major adverse cardiovascular events at 180 days from hospital admission.
   Results: 1548 patients were considered and divided in four groups, according UA concentration. Uricemia was significantly associated with gender, BMI, arterial hypertension, HDL-cholesterol, triglycerides, metabolic syndrome and glomerular filtration rate in univariate analysis. Multivariate logistic regression indicated that UA >6.0 mg/dL on admission increased the risk of in-hospital mortality in overall population (OR 2.9, 95%CI 1.4-6.1; p = 0.0057) and in patients with de novo ACS (OR 3.2, 95% CI 1.5-6.8; p = 0.0033). Comparable results were also obtained after adjusting the model for age, gender, body mass index, glomerular filtration rate, metabolic syndrome, acute revascularization and ethnicity. A positive correlation was observed between UA and C reactive protein concentrations in in-hospital deaths only (rho 0.41, p = 0.027).
   Conclusion: In patients with acute coronary syndrome, uricemia levels above the current international reference limit (6.0 mg/dl) were associated with in-hospital mortality, independently from ethnicity and renal function. (C) 2017 Published by Elsevier Ireland Ltd.
C1 [Magnoni, Marco; Berteotti, Martina; Ceriotti, Ferruccio; Mallia, Vincenzo; Vergani, Vittoria; Peretto, Giovanni; Cristell, Nicole; Cianflone, Domenico] IRCCS Osped San Raffaele, Via Olgettina 58, I-20132 Milan, Italy.
   [Magnoni, Marco; Berteotti, Martina; Ceriotti, Ferruccio; Mallia, Vincenzo; Vergani, Vittoria; Peretto, Giovanni; Cristell, Nicole; Cianflone, Domenico] Univ Vita Salute San Raffaele, Via Olgettina 58, I-20132 Milan, Italy.
   [Angeloni, Giulia] Univ Florence, Careggi Hosp, Dept Heart & Vessels, Florence, Italy.
   [Maseri, Attilio] Heart Care Fdn Onlus, Florence, Italy.
C3 Vita-Salute San Raffaele University; IRCCS Ospedale San Raffaele;
   Vita-Salute San Raffaele University; University of Florence; Azienda
   Ospedaliero Universitaria Careggi
RP Cianflone, D (corresponding author), IRCCS Osped San Raffaele, Via Olgettina 58, I-20132 Milan, Italy.; Cianflone, D (corresponding author), Univ Vita Salute San Raffaele, Via Olgettina 58, I-20132 Milan, Italy.
EM cianflone.domenico@hsr.it
RI Ceriotti, Ferruccio/S-9457-2019; Peretto, Giovanni/AAG-5128-2021;
   magnoni, marco/AAG-5312-2019
OI Ferruccio, Ceriotti/0000-0002-0958-5354
FU Menarini International Operations Luxembourg S.A
FX We thank Elisa Sala, PhD, Independent Medical Writer, for her medical
   editorial assistance with our report. We thank Mose Barbaro and Michele
   Raso for the technical assistance in uric acid measurement. We thank
   Menarini International Operations Luxembourg S.A. for their partial
   financial support by an unrestricted grant.
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NR 37
TC 50
Z9 52
U1 0
U2 8
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0167-5273
EI 1874-1754
J9 INT J CARDIOL
JI Int. J. Cardiol.
PD AUG 1
PY 2017
VL 240
BP 25
EP 29
DI 10.1016/j.ijcard.2017.04.027
PG 5
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA FA5AK
UT WOS:000405454800005
PM 28476518
DA 2025-06-11
ER

PT J
AU Van Rooyen, DM
   Gan, LT
   Yeh, MM
   Haigh, WG
   Larter, CZ
   Ioannou, G
   Teoh, NC
   Farrell, GC
AF Van Rooyen, Derrick M.
   Gan, Lay T.
   Yeh, Matthew M.
   Haigh, W. Geoffrey
   Larter, Claire Z.
   Ioannou, George
   Teoh, Narci C.
   Farrell, Geoffrey C.
TI Pharmacological cholesterol lowering reverses fibrotic NASH in obese,
   diabetic mice with metabolic syndrome
SO JOURNAL OF HEPATOLOGY
LA English
DT Article
DE Lipotoxicity; Atorvastatin; Ezetimibe; Inflammatory recruitment; Liver
   fibrosis
ID FATTY LIVER-DISEASE; NONALCOHOLIC STEATOHEPATITIS; EZETIMIBE; STEATOSIS;
   EFFICACY; THERAPY; STATINS; ROLES; CELLS; MODEL
AB Background & Aims: We have recently showed that hyperinsulinemia promotes hepatic free cholesterol (FC) accumulation in obese, insulin-resistant Alms1 mutant (foz/foz) mice with NASH. Here we tested whether cholesterol-lowering drugs reduce stress-activated c-Jun N-terminal kinase (JNK) activation, hepatocyte injury/apoptosis, inflammation, and fibrosis in this metabolic syndrome NASH model.
   Methods: Female foz/foz and WT mice were fed HF (0.2% cholesterol) 16 weeks, before adding ezetimibe (5 mg/kg), atorvastatin (20 mg/kg), or both to diet, another 8 weeks. Hepatic lipidomic analysis, ALT, liver histology, Sirius Red morphometry, hepatic mRNA and protein expression and immunohistochemistry (IHC) for apoptosis (M30), macrophages (F4/80), and polymorphs (myeloperoxidase) were determined.
   Results: In mice with NASH, ezetimibe/atorvastatin combination normalized hepatic FC but did not alter saturated free fatty acids (FFA) and had minimal effects on other lipids; ezetimibe and atorvastatin had similar but less profound effects. Pharmacological lowering of FC abolished INK activation, improved serum ALT, apoptosis, liver inflammation/NAFLD activity score, designation as "NASH", macrophage chemotactic protein-1 expression, reduced macrophage and polymorph populations, and liver fibrosis.
   Conclusions: Cholesterol lowering with ezetimibe/atorvastatin combination reverses hepatic FC but not saturated FFA accumulation. This dampens INK activation, ALT release, hepatocyte apoptosis, and inflammatory recruitment, with reversal of steatohepatitis pathology and liver fibrosis. Ezetimibe/statin combination is a potent, mechanism-based treatment that could reverse NASH and liver fibrosis. (C) 2013 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
C1 [Van Rooyen, Derrick M.; Gan, Lay T.; Larter, Claire Z.; Teoh, Narci C.; Farrell, Geoffrey C.] Australian Natl Univ, Sch Med, Liver Res Grp, Canberra Hosp, Garran, ACT 2605, Australia.
   [Yeh, Matthew M.] Univ Washington, Med Ctr, Dept Pathol, Seattle, WA 98195 USA.
   [Haigh, W. Geoffrey; Ioannou, George] Univ Washington, Dept Gastroenterol, Seattle, WA 98195 USA.
C3 Australian National University; Canberra Hospital; University of
   Washington; University of Washington Seattle; University of Washington;
   University of Washington Seattle
RP Farrell, GC (corresponding author), Australian Natl Univ, Sch Med, Gastroenterol & Hepatol Unit, Canberra Hosp, Yamba Dr, Garran, ACT 2605, Australia.
EM geoff.farrell@anu.edu.au
FU Australian National Health and Medical Research Council (NHMRC)
   [APP418101, APP585411]; NHMRC [585539]
FX Australian National Health and Medical Research Council (NHMRC) project
   grants APP418101 and APP585411, and NHMRC scholarship 585539.
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NR 30
TC 97
Z9 99
U1 1
U2 46
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0168-8278
EI 1600-0641
J9 J HEPATOL
JI J. Hepatol.
PD JUL
PY 2013
VL 59
IS 1
BP 144
EP 152
DI 10.1016/j.jhep.2013.02.024
PG 9
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 165KF
UT WOS:000320482100023
PM 23500152
DA 2025-06-11
ER

PT J
AU Chu, DJ
   Al Rifai, M
   Virani, SS
   Brawner, CA
   Nasir, K
   Al-Mallah, MH
AF Chu, Daniel J.
   Al Rifai, Mahmoud
   Virani, Salim S.
   Brawner, Clinton A.
   Nasir, Khurram
   Al-Mallah, Mouaz H.
TI The relationship between cardiorespiratory fitness, cardiovascular risk
   factors and atherosclerosis
SO ATHEROSCLEROSIS
LA English
DT Review
DE Cardiorespiratory fitness; Cardiovascular risk factors; Atherosclerosis;
   Stress testing; METS
ID ALL-CAUSE MORTALITY; PHYSICAL-ACTIVITY; EXERCISE CAPACITY; CORONARY
   ATHEROSCLEROSIS; MYOCARDIAL-INFARCTION; SCIENTIFIC STATEMENT; METABOLIC
   SYNDROME; STATIN THERAPY; HEART-FAILURE; MEN
AB Cardiorespiratory fitness (CRF) refers to the ability of the cardiopulmonary system to supply oxygen to skeletal muscles during exercise. Regular physical activity optimizes these systems by physiologic means that not only decrease cardiovascular risk factors but also independently affect mortality. Importantly, CRF is an integrative measure of the effects of its upstream risk factors including physical activity and genetics.
   In this review, we summarize the main methods that are frequently used to estimate CRF. We cite findings from the major studies on CRF, which demonstrate a beneficial effect on prevalent cardiovascular risk factor burden, subclinical atherosclerosis, and incident adverse outcomes including death, myocardial infarction, stroke, and cancer. We conclude by suggesting the incorporation of CRF into clinical decision-making given the prognostic information it provides.
C1 [Chu, Daniel J.] Baylor Coll Med, Dept Internal Med, Houston, TX 77030 USA.
   [Al Rifai, Mahmoud; Virani, Salim S.] Baylor Coll Med, Dept Med, Sect Cardiol, Houston, TX 77030 USA.
   [Virani, Salim S.] Michael E DeBakey VA Med Ctr, Sect Cardiol, Houston, TX USA.
   [Brawner, Clinton A.] Henry Ford Hosp, Div Cardiovasc Med, Detroit, MI 48202 USA.
   [Nasir, Khurram; Al-Mallah, Mouaz H.] Houston Methodist Hosp, Dept Cardiol, Houston, TX 77030 USA.
C3 Baylor College of Medicine; Baylor College of Medicine; Baylor College
   of Medicine; Baylor College Medical Hospital; Henry Ford Health System;
   Henry Ford Hospital; Houston Methodist
RP Al-Mallah, MH (corresponding author), Houston Methodist Hosp, Houston Methodist DeBakey Heart & Vasc Ctr, 6565 Fannin St,Smith 19, Houston, TX 77030 USA.
EM mal-mallah@houstonmethodist.org
RI Virani, Salim/AAF-1432-2019; Brawner, Clinton/K-6859-2019; Nasir,
   Khurram/A-2317-2008
OI Al-Mallah, Mouaz/0000-0003-2348-0484
CR Al Rifai M, 2019, AM J CARDIOL, V124, P511, DOI 10.1016/j.amjcard.2019.05.033
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NR 73
TC 30
Z9 30
U1 0
U2 12
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0021-9150
EI 1879-1484
J9 ATHEROSCLEROSIS
JI Atherosclerosis
PD JUL
PY 2020
VL 304
BP 44
EP 52
DI 10.1016/j.atherosclerosis.2020.04.019
PG 9
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA MM3KB
UT WOS:000550055300006
PM 32590246
DA 2025-06-11
ER

PT J
AU Fulop, JA
   Grimone, A
   Victorson, D
AF Fulop, Judy A.
   Grimone, Ania
   Victorson, David
TI Restoring Balance for People with Cancer Through Integrative Oncology
SO PRIMARY CARE
LA English
DT Article
DE Integrative medicine; Cancer; Nutrition; Chinese medicine; Nature;
   Quality of life; Ancient medicine; Mind-body medicine
ID QUALITY-OF-LIFE; RANDOMIZED CONTROLLED-TRIAL; STAGE BREAST-CANCER;
   TRADITIONAL CHINESE MEDICINE; PROSTATE-CANCER; ALTERNATIVE MEDICINE;
   METABOLIC SYNDROME; YOGA INTERVENTION; PHYSICAL-ACTIVITY; STRESS
   REDUCTION
AB Integrative Oncology incorporates conventional and western cancer treatment approaches with the best of ancient and traditional medicine including nutrition, supplements, Qigong, herbal medicine, mind-body practices, and more. This article offers a guiding conceptual paradigm from an integrative perspective based on the principles of balance and imbalance. An integrative approach is used to help improve quality of life, enhance lifestyle choices and mitigate symptoms and side effects from conventional treatments. By supporting the patient's mind, body and spirit throughout the cancer treatment journey, the primary care physician is in a key position to work with their patient's oncologist to provide supportive care and recommendations during cancer treatment.
C1 [Fulop, Judy A.] Northwestern Mem Hosp, Osher Ctr Integrat Med, Naturopath Oncol, Northwestern Med, 150 East Huron St,Suite 1100, Chicago, IL 60611 USA.
   [Fulop, Judy A.] Natl Univ Hlth Sci, Adjunct Fac, Naturopath Med, 200 E Roosevelt Rd, Lombard, IL 60148 USA.
   [Grimone, Ania] Northwestern Mem Hosp, Northwestern Med, Osher Ctr Integrat Med, Acupuncture & Chinese Med, 150 East Huron St,Suite 1100, Chicago, IL 60611 USA.
   [Victorson, David] Northwestern Univ, Dept Med Social Sci, Feinberg Sch Med, 2205 Tech Dr,Suite 2-120, Chicago, IL 60208 USA.
   [Victorson, David] Northwestern Med, Osher Ctr Integrat Med, 150 East Huron St,Suite 1100, Chicago, IL 60611 USA.
C3 Northwestern Memorial Hospital; Northwestern University; Feinberg School
   of Medicine; Northwestern University; Feinberg School of Medicine;
   Northwestern Memorial Hospital; Northwestern University; Feinberg School
   of Medicine; Northwestern University; Feinberg School of Medicine
RP Fulop, JA (corresponding author), Northwestern Mem Hosp, Osher Ctr Integrat Med, 150 East Huron St,Suite 1100, Chicago, IL 60611 USA.
EM jfulop@nm.org
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NR 75
TC 6
Z9 7
U1 1
U2 22
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0095-4543
EI 1558-299X
J9 PRIMARY CARE
JI Primary Care
PD JUN
PY 2017
VL 44
IS 2
BP 323
EP +
DI 10.1016/j.pop.2017.02.009
PG 15
WC Primary Health Care; Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA EW1CU
UT WOS:000402228300010
PM 28501232
DA 2025-06-11
ER

PT J
AU Womack, VY
   Ning, HY
   Lewis, CE
   Loucks, EB
   Puterman, E
   Reis, J
   Siddique, J
   Sternfeld, B
   Van Horn, L
   Carnethon, MR
AF Womack, Veronica Y.
   Ning, Hongyan
   Lewis, Cora E.
   Loucks, Eric B.
   Puterman, Eli
   Reis, Jared
   Siddique, Juned
   Sternfeld, Barbara
   Van Horn, Linda
   Carnethon, Mercedes R.
TI Relationship between Perceived Discrimination and Sedentary Behavior in
   Adults
SO AMERICAN JOURNAL OF HEALTH BEHAVIOR
LA English
DT Article
DE sedentary behaviors; discrimination; stress
ID TIME PHYSICAL-ACTIVITY; TYPE-2 DIABETES-MELLITUS; LEISURE-TIME;
   RACIAL-DISCRIMINATION; DEPRESSIVE SYMPTOMS; METABOLIC SYNDROME;
   AFRICAN-AMERICANS; AUSTRALIAN ADULTS; VIEWING TIME; YOUNG-ADULTS
AB Objective: To identify psychosocial factors associated with sedentary behavior, we tested whether perceived discrimination is associated with sedentary behavior. Methods: Black and white men and women (N = 3270) from the Coronary Artery Risk Development in Young Adults (CARDIA) Study reported experiences of discrimination and time engaged in total and screen time sedentary behaviors in 2010-11. Results: There were no associations of discriminatory experiences with total sedentary behavior time. However, discriminatory experiences were positively associated with screen time for black men (OR 1.81, 95% CI: 1.14, 2.86) and white women (OR 1.51, 95% CI: 1.14, 2.00) after adjusting for demographic and traditional cardiovascular disease risk factors. Conclusion: Among black men and white women, discriminatory experiences were correlated with more screen time sedentary behavior.
C1 [Womack, Veronica Y.; Ning, Hongyan; Siddique, Juned; Van Horn, Linda; Carnethon, Mercedes R.] Northwestern Univ, Dept Prevent Med, Feinberg Sch Med, Chicago, IL 60611 USA.
   [Lewis, Cora E.] Univ Alabama Birmingham, Sch Med, Dept Med, Birmingham, AL USA.
   [Loucks, Eric B.] Brown Univ, Dept Epidemiol, Providence, RI 02912 USA.
   [Puterman, Eli] Univ Calif San Francisco, Dept Psychiat, San Francisco, CA USA.
   [Reis, Jared] NHLBI, Div Prevent & Populat Sci, Bethesda, MD 20892 USA.
   [Sternfeld, Barbara] Kaiser Permanente, Div Res, Oakland, CA USA.
C3 Northwestern University; Feinberg School of Medicine; University of
   Alabama System; University of Alabama Birmingham; Brown University;
   University of California System; University of California San Francisco;
   National Institutes of Health (NIH) - USA; NIH National Heart Lung &
   Blood Institute (NHLBI); Kaiser Permanente
RP Womack, VY (corresponding author), Northwestern Univ, Dept Prevent Med, Feinberg Sch Med, Chicago, IL 60611 USA.
EM veronica.womack@northwestern.edu
OI Carnethon, Mercedes/0000-0001-7035-0848; Puterman,
   Eli/0000-0002-5898-2348
FU NCI NIH HHS [K07 CA154862] Funding Source: Medline; NHLBI NIH HHS
   [HHSN268201300028C, T32 HL069771, T32-HL-069771-07, HHSN268201300026C]
   Funding Source: Medline; NIA NIH HHS [AG0005] Funding Source: Medline;
   NIDDK NIH HHS [P30 DK079626, P30 DK092949] Funding Source: Medline;
   Intramural NIH HHS Funding Source: Medline
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NR 42
TC 18
Z9 21
U1 2
U2 19
PU PNG PUBLICATIONS
PI OAK RIDGE
PA 2205-K OAK RIDGE RD, #115, OAK RIDGE, NC 27310 USA
SN 1945-7359
J9 AM J HEALTH BEHAV
JI Am. J. Health Behav.
PD SEP
PY 2014
VL 38
IS 5
BP 641
EP 649
DI 10.5993/AJHB.38.5.1
PG 9
WC Public, Environmental & Occupational Health
WE Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA AS1JD
UT WOS:000344036500001
PM 24933133
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Wagner, IV
   Oliver, E
   Dötsch, J
   Söder, O
AF Wagner, Isabel Viola
   Oliver, Elizabeth
   Doetsch, Joerg
   Soeder, Olle
TI Adverse effects of metabolic disorders in childhood on adult
   reproductive function and fertility in the male
SO JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
LA English
DT Review
DE childhood obesity; diabetes mellitus type I; fertility; metabolic
   diseases; reproductive function
ID DIABETES-MELLITUS; LUTEINIZING-HORMONE; TESTICULAR STEROIDOGENESIS;
   INDUCED HYPERGLYCEMIA; OXIDATIVE STRESS; CELL FUNCTION; LEYDIG-CELLS;
   RAT TESTES; LEPTIN; INSULIN
AB Over the last 50 years, there has been a steady decline in fertility rates in humans, which has occurred in parallel with an increasing incidence of obesity and metabolic disorders. The potential impact of these disorders and plausible mechanisms by which they negatively influence male reproduction are only partly understood and published data are often controversial. Obesity is one of the most important health challenges worldwide and is becoming more prevalent in children and adolescents. Obesity, the metabolic syndrome and related comorbidities can lead to impaired male reproductive function, including adverse effects on spermatogenesis and steroidogenesis as illustrated by reduced sperm number and quality, decreased testosterone levels and elevated inflammatory markers. The incidence of diabetes mellitus type I is also dramatically increasing and may negatively impact spermatogenesis and testicular function, resulting in decreased serum testosterone and epididymal weight. In this review, we summarize and discuss the effects of metabolic diseases that typically develop during childhood and adolescence on later reproductive function and fertility. While impact on reproductive health is likely observed in both sexes, we have chosen to focus on the male in the current review. Specifically, we illustrate adverse effects of obesity, type 1 diabetes, the metabolic syndrome and insulin resistance on sperm function and testosterone metabolism. Identification of pathophysiological mechanisms during childhood may open up new avenues for early prevention and treatment resulting in better reproductive outcomes and improved fertility rates during adulthood.
C1 [Wagner, Isabel Viola; Soeder, Olle] Karolinska Inst, Dept Womens & Childrens Hlth, Pediat Endocrinol Unit, Stockholm, Sweden.
   [Wagner, Isabel Viola; Doetsch, Joerg] Univ Cologne, Med Fac, Dept Pediat, Pediat Endocrinol Unit, Cologne, Germany.
   [Wagner, Isabel Viola; Soeder, Olle] Univ Lubeck, Dept Paediat, Div Pediat Endocrinol & Diabet, Ratzeburger Allee 160, D-23562 Lubeck, Germany.
   [Oliver, Elizabeth] Karolinska Univ Hosp, Karolinska Inst, Dept Womens & Childrens Hlth, Childhood Canc Res Unit,NORDFERTIL Res Lab Stockh, Solna, Sweden.
C3 Karolinska Institutet; University of Cologne; University of Lubeck;
   Karolinska Institutet; Karolinska University Hospital
RP Wagner, IV (corresponding author), Karolinska Inst, Dept Womens & Childrens Hlth, Pediat Endocrinol Unit, Stockholm, Sweden.; Wagner, IV (corresponding author), Univ Cologne, Med Fac, Dept Pediat, Pediat Endocrinol Unit, Cologne, Germany.; Wagner, IV (corresponding author), Univ Lubeck, Dept Paediat, Div Pediat Endocrinol & Diabet, Ratzeburger Allee 160, D-23562 Lubeck, Germany.
EM IsabelViola.Wagner@uksh.de
RI Frielitz, Fabian/ABH-2518-2020
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NR 83
TC 4
Z9 4
U1 1
U2 5
PU WALTER DE GRUYTER GMBH
PI BERLIN
PA GENTHINER STRASSE 13, D-10785 BERLIN, GERMANY
SN 0334-018X
EI 2191-0251
J9 J PEDIATR ENDOCR MET
JI J. Pediatr. Endocrinol. Metab.
PD JAN
PY 2021
VL 34
IS 1
BP 13
EP 23
DI 10.1515/jpem-2020-0276
PG 11
WC Endocrinology & Metabolism; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Pediatrics
GA PR2RJ
UT WOS:000607088200002
PM 33185575
DA 2025-06-11
ER

PT J
AU Rachma, DE
   Murwani, R
   Juniarto, AZ
AF Rachma, Devi Elvina
   Murwani, Retno
   Juniarto, Achmad Zulfa
TI Dietary Fresh and Boiled Mangkokan Leaves (Nothopanax
   scutellarius) Normalized Body Weight, Serum Lipid Profile and
   Malondialdehyde in Metabolic Syndrome Rats
SO CURRENT RESEARCH IN NUTRITION AND FOOD SCIENCE
LA English
DT Article
DE Dyslipidemia; My Plate; Piringku; Phytonutrien; Vegetables
ID HIGH-FAT DIET; CONSUMPTION; FLAVONOIDS; FRUIT; RISK
AB The antioxidant activity of Nothopanax scutellarius ( Burm. f.) Merr, an edible plant, can prevent oxidative stress in metabolic syndrome (MetS). Thus, our research aimed to study the effect of dietary inclusion of fresh or boiled N. scutellarius on body weight and biochemical markers of Wistar rats with MetS. Twenty-four male Wistar rats were divided randomly into four groups, i.e., normal control group, high-fat-high-fructose diet (HFFD)group, fresh N. scutellarius (FNs) group, and boiled N. scutellarius (BNs)group. The normal control group was fed only a standard diet during the entire experiment. High-fat and high-fructose (HFHFr) diet accompanied with 20% fructose in drinking water to induce MetS was given to the HFFD, FNs, and BNs groups for 29 days. This was followed by a 29-day intervention diet in which standard normal diet, fresh N. scutellarius-containing standard diet, and boiled N. scutellarius-containing standard diet were given to the HFFD, FNs,and BNs groups, respectively. HFHFr diet significantly (p<0.05) raised fasting blood glucose (FBG), serum triglyceride, total cholesterol, LDL-cholesterol, and Malondialdehyde (MDA), and significantly (p<0.05) reduced HDL-cholesterol. After 29 days on the intervention diet, serum triglycerides, total cholesterol, and LDL-cholesterol levels were found to decrease, and HDL-cholesterol levels were found to increase significantly (p<0.05).Thus, it can be concluded that dietary intake of N. scutellarius for 29 days can improve MetS components, i.e.,FBG, serum lipid profile, and MDA, similar to those seen in rats on a normal control diet.
C1 [Rachma, Devi Elvina; Murwani, Retno; Juniarto, Achmad Zulfa] Univ Diponegoro, Fac Med, Dept Nutr, Master Programme Nutr Sci, Semarang 50275, Indonesia.
   [Murwani, Retno] Univ Diponegoro, Fac Anim & Agr Sci, Dept Anim Sci, Lab Physiol & Biochem, Bldg E-1st Floor, Semarang 50275, Indonesia.
   [Murwani, Retno] Univ Diponegoro, Nat Prod Lab, Integrated Lab Res & Serv, Lab Terpadu, Semarang 50275, Indonesia.
   [Juniarto, Achmad Zulfa] Univ Diponegoro, Fac Med, Semarang 50275, Indonesia.
C3 Diponegoro University; Diponegoro University; Diponegoro University;
   Diponegoro University
RP Murwani, R (corresponding author), Univ Diponegoro, Fac Anim & Agr Sci, Dept Anim Sci, Lab Physiol & Biochem, Bldg E-1st Floor, Semarang 50275, Indonesia.
EM rmurwani.undip@gmail.com
RI Murwani, Retno/AAB-3647-2020; Juniarto, Achmad Zulfa/HZM-2392-2023
OI Juniarto, Achmad Zulfa/0000-0002-5466-7690; Murwani,
   Retno/0000-0002-6237-8354
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NR 50
TC 2
Z9 2
U1 0
U2 0
PU ENVIRO RESEARCH PUBLISHERS
PI BHOPAL
PA 14 GREEN HOUSE, PRINCE COLONY, SHAHJAHANABAD, BHOPAL, MADHYA PRADESH 462
   001, INDIA
SN 2347-467X
EI 2322-0007
J9 CURR RES NUTR FOOD S
JI Curr. Res. Nutr. Food Sci.
PD DEC
PY 2020
VL 8
IS 3
BP 889
EP 902
DI 10.12944/CRNFSJ.8.3.19
PG 14
WC Food Science & Technology
WE Emerging Sources Citation Index (ESCI)
SC Food Science & Technology
GA QK1KZ
UT WOS:000620139900019
OA gold
DA 2025-06-11
ER

PT J
AU Andrade, N
   Andrade, S
   Silva, C
   Rodrigues, I
   Guardao, L
   Guimaraes, JT
   Keating, E
   Martel, F
AF Andrade, Nelson
   Andrade, Sara
   Silva, Claudia
   Rodrigues, Ilda
   Guardao, Luisa
   Guimaraes, Joao T.
   Keating, Elisa
   Martel, Fatima
TI Chronic consumption of the dietary polyphenol chrysin attenuates
   metabolic disease in fructose-fed rats
SO EUROPEAN JOURNAL OF NUTRITION
LA English
DT Article
DE Metabolic syndrome; Chrysin; Fructose; Hypertension; Triacylglycerol
ID INSULIN-RESISTANCE; OXIDATIVE STRESS; BLOOD-PRESSURE; ANGIOTENSIN
   SYSTEM; RENIN-ANGIOTENSIN; LIPID-METABOLISM; LIVER; DYSFUNCTION; INJURY;
   COMPLICATIONS
AB Purpose Metabolic syndrome (MS) is a major public health issue worldwide and fructose consumption has been associated with MS development. Recently, we showed that the dietary polyphenol chrysin is an effective inhibitor of fructose uptake by human intestinal epithelial cells. Therefore, our aim was to investigate if chrysin interferes with the development of MS induced by fructose in an animal model. Methods Adult male Sprague-Dawley rats (220-310 g) were randomly divided into four groups: (A) tap water (control), (B) tap water and a daily dose of chrysin (100 mg/kg) by oral administration (chrysin) (C) 10% fructose in tap water (fructose), and (D) 10% fructose in tap water and a daily dose of chrysin (100 mg/kg) by oral administration (fructose + chrysin). All groups were fed ad libitum with standard laboratory chow diet and dietary manipulation lasted 18 weeks. Results Fructose-feeding for 18 weeks induced an increase in serum triacylglycerols, insulin and angiotensin II levels and in hepatic fibrosis and these changes did not occur in fructose + chrysin rats. Moreover, the increase in both systolic and diastolic blood pressure which was found in fructose-fed animals from week 14th onwards was not observed in fructose + chrysin animals. In contrast, the increase in energy consumption, liver/body, heart/body and right kidney/body weight ratios, serum proteins, serum leptin and liver triacylglycerols observed in fructose-fed rats was not affected by chrysin. Conclusions Chrysin was able to protect against some of the MS features induced by fructose-feeding.
C1 [Andrade, Nelson; Andrade, Sara; Silva, Claudia; Rodrigues, Ilda; Guardao, Luisa; Guimaraes, Joao T.; Keating, Elisa; Martel, Fatima] Univ Porto, Fac Med Porto, Dept Biomed, Unit Biochem, Porto, Portugal.
   [Andrade, Nelson; Andrade, Sara; Silva, Claudia; Martel, Fatima] Univ Porto, I3S, Porto, Portugal.
   [Guimaraes, Joao T.] Sao Joao Hosp Ctr, Dept Clin Pathol, Porto, Portugal.
   [Guimaraes, Joao T.] Univ Porto, Inst Publ Hlth, Porto, Portugal.
   [Keating, Elisa] Univ Porto, Ctr Res Hlth Technol & Informat Syst, CINTESIS, Porto, Portugal.
C3 Universidade do Porto; Universidade do Porto; i3S - Instituto de
   Investigacao e Inovacao em Saude, Universidade do Porto; Sao Joao
   Hospital; Universidade do Porto; Universidade do Porto
RP Martel, F (corresponding author), Univ Porto, Fac Med Porto, Dept Biomed, Unit Biochem, Porto, Portugal.; Martel, F (corresponding author), Univ Porto, I3S, Porto, Portugal.
EM fmartel@med.up.pt
RI Keating, Elisa/JDW-8704-2023; Martel, Felix/JFJ-0587-2023; Andrade,
   Nelson/AAK-3763-2021; Guimaraes, Joao Tiago/T-3079-2017; Andrade,
   Sara/F-5871-2017
OI Martel, Fatima/0000-0002-0525-3416; Guimaraes, Joao
   Tiago/0000-0003-4836-6311; Rodrigues, Ilda/0000-0002-5581-7670; Keating,
   Elisa/0000-0002-3904-9907; Andrade, Sara/0000-0001-9825-2772; Andrade,
   Nelson/0000-0003-2600-8599; Silva, Claudia/0000-0003-2937-974X
FU CAPES-Brazilian Federal Agency for Support and Evaluation of Graduate
   Education within the Ministry of Education of Brazil [10103/13-9]
FX This work was financed by CAPES-Brazilian Federal Agency for Support and
   Evaluation of Graduate Education within the Ministry of Education of
   Brazil, for financing this project-PN: 10103/13-9.
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NR 68
TC 23
Z9 24
U1 2
U2 32
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1436-6207
EI 1436-6215
J9 EUR J NUTR
JI Eur. J. Nutr.
PD FEB
PY 2020
VL 59
IS 1
BP 151
EP 165
DI 10.1007/s00394-019-01895-9
PG 15
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA KJ5DD
UT WOS:000512078900014
PM 30631887
DA 2025-06-11
ER

PT J
AU He, B
   Yu, C
   Du, RY
   Wang, Y
   Han, P
AF He, Bing
   Yu, Chong
   Du, Runyu
   Wang, Yong
   Han, Ping
TI Roux-en-Y Esophagojejunostomy Reduces Serum and Aortic Inflammatory
   Biomarkers in Type 2 Diabetic Rats
SO OBESITY SURGERY
LA English
DT Article
DE Type 2 diabetes mellitus (T2DM); Roux-en-Y esophagojejunostomy;
   Inflammation
ID GASTRIC BYPASS-SURGERY; INSULIN SENSITIVITY; BARIATRIC SURGERY;
   CARDIOVASCULAR-DISEASE; ENDOTHELIAL FUNCTION; METABOLIC SYNDROME;
   ATHEROSCLEROSIS; MECHANISMS; RESISTANCE; STRESS
AB Recent studies have shown the reduction in serum inflammatory biomarkers by bariatric surgery. However, few studies have reported its effects on local vascular inflammation. We have investigated the effects of Roux-en-Y esophagojejunostomy on both serum and aortic tissue inflammation biomarkers in type 2 diabetic rats.
   Sprague-Dawley rats were divided into five groups: diabetic RYEJ, diabetic RYEJ sham, diabetic food restriction, diabetic rats, and non-diabetic control (n = 6/group). At 4 weeks after surgery, serum leptin, interleukin-6, C-reactive protein, interleukin-1 beta (IL-1 beta), tumor necrosis factor-alpha (TNF-alpha), chemerin, and adiponectin were measured. Aortic expression of c-Jun NH2-terminal kinase and p38 mitogen-activated protein kinases was examined with immunohistochemistry; aortic expression of IL-1 beta, TNF-alpha, intercellular adhesion molecule-1, and vascular adhesion molecule-1 was assessed with western blotting. Hyperinsulinemic-euglycemic clamps with tracer infusion were completed to assess insulin sensitivity.
   Roux-en-Y esophagojejunostomy significantly decreased serum inflammatory parameters and increased the concentration of the anti-inflammatory mediator adiponectin. The aortic inflammatory protein expression was markedly decreased in the diabetic RYEJ group as compared with that of the diabetic group (P < 0.05). Additionally, Roux-en-Y esophagojejunostomy improved insulin sensitivity and dyslipidemia and decreased body weight and total body fat.
   Roux-en-Y esophagojejunostomy reduces the systemic and local vascular inflammation. The improvements in systemic and vascular inflammation are not wholly dependent on the magnitude of weight loss. Moreover, Roux-en-Y esophagojejunostomy alleviates insulin resistance and improves the features of metabolic syndrome, leading to a reduction in multiple cardiovascular risks.
C1 [He, Bing; Yu, Chong; Du, Runyu; Han, Ping] China Med Univ, Dept Endocrinol, Shengjing Hosp, Shenyang 110004, Liaoning, Peoples R China.
   [Wang, Yong] China Med Univ, Dept Gen Surg, Shengjing Hosp, Shenyang 110004, Liaoning, Peoples R China.
C3 China Medical University; China Medical University
RP Han, P (corresponding author), China Med Univ, Dept Endocrinol, Shengjing Hosp, Shenyang 110004, Liaoning, Peoples R China.
EM litong909@hotmail.com; cmuych@126.com; runyu@126.com;
   wangy@sj-hospital.org; hb3h@hotmail.com
RI He, Bing/AAW-4869-2020
OI Du, Runyu/0000-0002-7460-4734; He, Bing/0000-0002-9694-6591
FU Research Fund for the Doctoral Program of Higher Education of China
   [20112104110014]; Outstanding Scientific Fund of Shengjing Hospital
   [201101]
FX This study was supported by a Research Fund for the Doctoral Program of
   Higher Education of China (grant no. 20112104110014) and an Outstanding
   Scientific Fund of Shengjing Hospital (grant no. 201101).
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NR 36
TC 2
Z9 2
U1 0
U2 1
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0960-8923
EI 1708-0428
J9 OBES SURG
JI Obes. Surg.
PD JUN
PY 2014
VL 24
IS 6
BP 916
EP 926
DI 10.1007/s11695-014-1195-0
PG 11
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA AH8FY
UT WOS:000336372300014
PM 24573962
DA 2025-06-11
ER

PT J
AU Grant, WB
   Al Anouti, F
   Boucher, BJ
   Fakhoury, HMA
   Moukayed, M
   Pilz, S
   Al-Daghri, NM
AF Grant, William B.
   Al Anouti, Fatme
   Boucher, Barbara J.
   Fakhoury, Hana M. A.
   Moukayed, Meis
   Pilz, Stefan
   Al-Daghri, Nasser M.
TI Evidence That Increasing Serum 25(OH)D Concentrations to 30 ng/mL in the
   Kingdom of Saudi Arabia and the United Arab Emirates Could Greatly
   Improve Health Outcomes
SO BIOMEDICINES
LA English
DT Review
DE breast cancer; calcitriol; case-control study; dementia; hill's
   criteria; metabolic syndrome; Middle East; recommendations; season;
   solar UVB
ID VITAMIN-D STATUS; SOLAR ULTRAVIOLET-B; CHRONIC KIDNEY-DISEASE; ALL-CAUSE
   MORTALITY; D DEFICIENCY; 25-HYDROXYVITAMIN D; INSULIN-RESISTANCE; D
   SUPPLEMENTATION; METABOLIC SYNDROME; OXIDATIVE STRESS
AB Accumulating evidence supports the potential protective effects of vitamin D against chronic diseases such as Alzheimer's disease, autoimmune diseases, cancers, cardiovascular disease (ischaemic heart disease and stroke), type 2 diabetes, hypertension, chronic kidney disease, stroke, and infectious diseases such as acute respiratory tract diseases, COVID-19, influenza, and pneumonia, as well as adverse pregnancy outcomes. The respective evidence is based on ecological and observational studies, randomized controlled trials, mechanistic studies, and Mendelian randomization studies. However, randomized controlled trials on vitamin D supplementation have largely failed to show benefits, probably due to poor design and analysis. In this work, we aim to use the best available evidence on the potential beneficial effects of vitamin D to estimate the expected reduction in incidence and mortality rates of vitamin D-related diseases in the Kingdom of Saudi Arabia and the United Arab Emirates if minimum serum 25(OH)D concentrations were to be raised to 30 ng/mL. Estimated reductions by 25% for myocardial infarction incidence, 35% for stroke incidence, 20 to 35% for cardiovascular disease mortality, and 35% for cancer mortality rates depicted a promising potential for raising serum 25(OH)D. Methods to increase serum 25(OH)D concentrations at the population level could include food fortification with vitamin D-3, vitamin D supplementation, improved dietary vitamin D intake, and sensible sun exposure.
C1 [Grant, William B.] Sunlight Nutr & Hlth Res Ctr, POB 641603, San Francisco, CA 94164 USA.
   [Al Anouti, Fatme] Zayed Univ, Coll Nat & Hlth Sci, Dept Hlth Sci, POB 144534, Abu Dhabi, U Arab Emirates.
   [Boucher, Barbara J.] Queen Mary Univ London, Blizard Inst, Barts & London Sch Med & Dent, London E1 2AT, England.
   [Fakhoury, Hana M. A.] Alfaisal Univ, Coll Med, Dept Biochem & Mol Med, Riyadh 11533, Saudi Arabia.
   [Moukayed, Meis] Amer Univ Dubai, Sch Arts & Sci, POB 28282, Dubai, U Arab Emirates.
   [Pilz, Stefan] Med Univ Graz, Dept Internal Med, Div Endocrinol & Diabetol, A-8036 Graz, Austria.
   [Al-Daghri, Nasser M.] King Saud Univ, Coll Sci, Chair Biomarkers Chron Dis, Biochem Dept, Riyadh 11451, Saudi Arabia.
C3 Zayed University; University of London; Queen Mary University London;
   American University in Dubai (AUD); Medical University of Graz; King
   Saud University
RP Al Anouti, F (corresponding author), Zayed Univ, Coll Nat & Hlth Sci, Dept Hlth Sci, POB 144534, Abu Dhabi, U Arab Emirates.; Al-Daghri, NM (corresponding author), King Saud Univ, Coll Sci, Chair Biomarkers Chron Dis, Biochem Dept, Riyadh 11451, Saudi Arabia.
EM fatme.alanouti@zu.ac.ae; ndaghri@ksu.edu.sa
RI Fakhoury, Hana/F-6457-2017; Al-Daghri, Nasser/A-8360-2011; Grant,
   William/B-8311-2009; Al Anouti, Fatme/ADY-7764-2022
OI Al-Daghri, Nasser/0000-0001-5472-1725; Moukayed,
   Meis/0000-0003-3951-7712; Grant, William/0000-0002-1439-3285; Fakhoury,
   Hana/0000-0001-9974-2108; Boucher, Barbara J/0000-0003-1206-7555; Al
   Anouti, Fatme/0000-0002-1993-6656
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NR 270
TC 7
Z9 7
U1 1
U2 6
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2227-9059
J9 BIOMEDICINES
JI Biomedicines
PD APR
PY 2023
VL 11
IS 4
AR 994
DI 10.3390/biomedicines11040994
PG 40
WC Biochemistry & Molecular Biology; Medicine, Research & Experimental;
   Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Research & Experimental Medicine;
   Pharmacology & Pharmacy
GA E6FK3
UT WOS:000976476300001
PM 37189612
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Yan, ZY
   Fan, YG
   Meng, ZW
   Huang, C
   Liu, M
   Zhang, Q
   Song, K
   Jia, QY
AF Yan, Ziyu
   Fan, Yaguang
   Meng, Zhaowei
   Huang, Chao
   Liu, Ming
   Zhang, Qing
   Song, Kun
   Jia, Qiyu
TI The relationship between red blood cell distribution width and metabolic
   syndrome in elderly Chinese: a cross-sectional study
SO LIPIDS IN HEALTH AND DISEASE
LA English
DT Article
DE Red blood cell distribution width (RDW); Metabolic syndrome (MS);
   Gender; Age
ID INFLAMMATORY BIOMARKERS; ASSOCIATION; POLYMORPHISMS; HYPERURICEMIA;
   DEFORMABILITY; PARAMETERS; MORTALITY; STRESS; ANEMIA
AB ObjectiveMetabolic syndrome (MS) is a group of risk factors which includes hypertension, hyperglycemia, abnormal cholesterol levels, and obesity. Red blood cell distribution width (RDW) is a parameter that reflects the heterogeneity of erythrocyte volume. But the relationship between MS and RDW is intricate and remains poorly understood. We hypothesized that high RDW was associated with MS via inflammation. Our study aimed to investigate the association between RDW and MS in Chinese elderly large cohort. If RDW had a strong correlation with MS, RDW could become a predictor of MS?MethodsWe recruited 10,887 ostensibly healthy participants aged from 60 to 93 (5795 male, 5092 female). Associations between RDW and other variables were assessed by Pearson correlation. Crude and adjusted odds ratio for MS with 95% confidence intervals was calculated by binary logistic regression models.ResultsIn elderly Chinese, RDW was significantly higher in males than in females. The prevalence of both men and women decreased with the rise of RDW. For both sexes, RDW demonstrated positive correlations with age, systolic blood pressure (0.070 in males,0.058 in females), high density lipoprotein(0.027in males,0.064 in females), negative correlations with triglycerides (-0.120 in males,-0.074 in females) and fasting glucose (-0.048 in males,-0.016 in females). Notably, we detected the associated reduced risks at the the third and fourth quartile of RDW in males. In women, there was no statistical significance.ConclusionWe found the adjusted odds ratios of MS was lower at the third and fourth quartile of RDW in males.
C1 [Yan, Ziyu; Fan, Yaguang; Meng, Zhaowei] Tianjin Med Univ Gen Hosp, Dept Nucl Med, Anshan Rd 154, Tianjin 300052, Peoples R China.
   [Huang, Chao] Univ Hull, Allam Med Bldg,Cottingham Rd, Kingston Upon Hull HU6 7RX, N Humberside, England.
   [Liu, Ming] Tianjin Med Univ Gen Hosp, Dept Endocrinol & Metab, Tianjin, Peoples R China.
   [Zhang, Qing; Song, Kun; Jia, Qiyu] Tianjin Med Univ Gen Hosp, Dept Hlth Management, Tianjin, Peoples R China.
C3 Tianjin Medical University; University of Hull; Tianjin Medical
   University; Tianjin Medical University
RP Meng, ZW (corresponding author), Tianjin Med Univ Gen Hosp, Dept Nucl Med, Anshan Rd 154, Tianjin 300052, Peoples R China.
EM jamesmencius@163.com
RI Fan, Ya-Guang/AGK-7788-2022; Meng, Zhaowei/AAE-4732-2022; Liu,
   Ming/C-7499-2011
FU National Key Clinical Specialty Project; Tianjin Medical University
   General Hospital New Century Excellent Talent Program; Young and
   Middle-aged Innovative Talent Training Program from Tianjin Education
   Committee; Talent Fostering Program (the 131 Project) from Tianjin
   Education Committee, Tianjin Human Resources and Social Security Bureau;
   China National Natural Science Foundation [81872235, 81870533, 71804124,
   81571709]; Key Project of Tianjin Science and Technology Committee
   Foundation [16JCZDJC34300]; Tianjin Science and Technology Committee
   Foundation [17JCYBJC25400, 15YFYZSY00020, 15JCYBJC28000, 11ZCGYSY05700,
   12ZCZDSY20400, 13ZCZDSY20200]; Tianjin Education Committee grant
   [20110152]; Tianjin Health Bureau grant [2015KZ117]
FX This study was supported by the National Key Clinical Specialty Project
   (awarded to the Departments of Nuclear Medicine and Radiology).This
   study was supported by Tianjin Medical University General Hospital New
   Century Excellent Talent Program; Young and Middle-aged Innovative
   Talent Training Program from Tianjin Education Committee; and Talent
   Fostering Program (the 131 Project) from Tianjin Education Committee,
   Tianjin Human Resources and Social Security Bureau (awarded to Zhaowei
   Meng).This study was supported by China National Natural Science
   Foundation grant 81571709, Key Project of Tianjin Science and Technology
   Committee Foundation grant 16JCZDJC34300 (awarded to Zhaowei Meng).This
   study was also supported by Tianjin Science and Technology Committee
   Foundation grants 11ZCGYSY05700, 12ZCZDSY20400, 13ZCZDSY20200 and
   (awarded to Qing Zhang, Qiyu Jia and Kun Song).This study was also
   supported by China National Natural Science Foundation grant 81872235,
   81870533 and 71804124; Tianjin Science and Technology Committee
   Foundation grant 17JCYBJC25400, 15YFYZSY00020 and 15JCYBJC28000; Tianjin
   Education Committee grant 20110152; Tianjin Health Bureau grant
   2015KZ117.
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NR 38
TC 16
Z9 16
U1 0
U2 3
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1476-511X
J9 LIPIDS HEALTH DIS
JI Lipids Health Dis.
PD JAN 31
PY 2019
VL 18
AR 34
DI 10.1186/s12944-019-0978-7
PG 9
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA HJ9VS
UT WOS:000457548000003
PM 30704536
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Eirin, A
   Zhu, XY
   Jonnada, S
   Lerman, A
   van Wijnen, AJ
   Lerman, LO
AF Eirin, Alfonso
   Zhu, Xiang-Yang
   Jonnada, Sreela
   Lerman, Amir
   van Wijnen, Andre J.
   Lerman, Lilach O.
TI Mesenchymal Stem Cell-Derived Extracellular Vesicles Improve the Renal
   Microvasculature in Metabolic Renovascular Disease in Swine
SO CELL TRANSPLANTATION
LA English
DT Article
DE metabolic syndrome; renovascular disease; mesenchymal stem cells;
   extracellular vesicles; microcirculation
ID ARTERY STENOSIS; GLOMERULAR-FILTRATION; REPERFUSION INJURY; PROTEOMIC
   ANALYSIS; KIDNEY; REVASCULARIZATION; ANGIOGENESIS; HEMODYNAMICS;
   HYPERTENSION; INFLAMMATION
AB Background: Extracellular vesicles (EVs) released from mesenchymal stem/stromal cells (MSCs) mediate their paracrine effect, but their efficacy to protect the microcirculation of the kidney is unknown. Using a novel swine model of unilateral renovascular disease (RVD) complicated by metabolic syndrome (MetS), we tested the hypothesis that EVs would attenuate renal microvascular loss. Methods: Four groups of pigs (n = 7 each) were studied after 16 weeks of diet-induced MetS and RVD (MetS+RVD), MetS+RVD treated 4 weeks earlier with a single intra-renal delivery of EVs harvested from autologous adipose tissue-derived MSCs, and Lean and MetS Sham controls. Stenotic-kidney renal blood flow (RBF) and glomerular filtration rate (GFR) were measured in-vivo (fast CT), whereas EV characteristics, renal microvascular architecture (micro-CT), and injury pathways were studied ex-vivo. Results: mRNA sequencing and proteomic analysis revealed that EVs are packed with several pro-angiogenic genes and proteins, such as vascular endothelial growth factor. Labeled EVs were detected in the stenotic kidney 4 weeks after injection internalized by tubular and endothelial cells. EVs restored renal expression of angiogenic factors and improved cortical microvascular and peritubular capillary density. Renal apoptosis, oxidative stress, tubular injury, and fibrosis were also attenuated in EV-treated pigs. RBF and GFR decreased in MetS+RVD compared with MetS, but normalized in MetS+RVD+EVs. Conclusions: Intra-renal delivery of MSC-derived EVs bearing pro-angiogenic properties restored the renal microcirculation and in turn hemodynamics and function in chronic experimental MetS+RVD. Our study suggests a novel therapeutic potential for MSC-derived EVs in restoring renal hemodynamics in experimental MetS+RVD.
C1 [Eirin, Alfonso; Zhu, Xiang-Yang; Jonnada, Sreela; Lerman, Lilach O.] Mayo Clin, Div Nephrol, Rochester, MN 55905 USA.
   [Eirin, Alfonso; Zhu, Xiang-Yang; Jonnada, Sreela; Lerman, Lilach O.] Mayo Clin, Div Hypertens, Rochester, MN 55905 USA.
   [Lerman, Amir; Lerman, Lilach O.] Mayo Clin, Cardiovasc Dis, Rochester, MN 55905 USA.
   [van Wijnen, Andre J.] Mayo Clin, Orthoped Surg, Rochester, MN 55905 USA.
C3 Mayo Clinic; Mayo Clinic; Mayo Clinic; Mayo Clinic
RP Lerman, LO (corresponding author), Mayo Clin, Div Nephrol & Hypertens, 200 First St SW, Rochester, MN 55905 USA.
EM Lerman.Lilach@Mayo.Edu
RI Eirin, Alfonso/N-9873-2013; Lerman, Lilach/M-4962-2017; van Wijnen,
   Andre/AAG-3578-2019
OI van Wijnen, Andre J./0000-0002-4458-0946; Eirin,
   Alfonso/0000-0002-3864-9644
FU NHLBI NIH HHS [R01 HL123160] Funding Source: Medline; NIDDK NIH HHS [K08
   DK106427, R01 DK102325, U01 DK104273, R01 DK073608] Funding Source:
   Medline
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NR 48
TC 78
Z9 84
U1 0
U2 10
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0963-6897
EI 1555-3892
J9 CELL TRANSPLANT
JI Cell Transplant.
PD JUL
PY 2018
VL 27
IS 7
BP 1080
EP 1095
DI 10.1177/0963689718780942
PG 16
WC Cell & Tissue Engineering; Medicine, Research & Experimental;
   Transplantation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Research & Experimental Medicine; Transplantation
GA GO8KQ
UT WOS:000440338700007
PM 29954220
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Jover, B
   Reynes, C
   Rugale, C
   Reboul, C
   Jeanson, L
   Tournier, M
   Lajoix, AD
   Desmetz, C
AF Jover, Bernard
   Reynes, Christelle
   Rugale, Caroline
   Reboul, Cyril
   Jeanson, Laura
   Tournier, Michel
   Lajoix, Anne Dominique
   Desmetz, Caroline
TI Sodium restriction modulates innate immunity and prevents cardiac
   remodeling in a rat model of metabolic syndrome
SO BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
LA English
DT Article
DE Low sodium diet; Cardiac hypertrophy; Fibrosis; Innate immunity;
   Macrophage; Inflammation
ID INFLAMMATORY FACTOR-I; TOLL-LIKE RECEPTORS; LEFT-VENTRICULAR
   HYPERTROPHY; COLLAGEN GENE-EXPRESSION; NECROSIS-FACTOR-ALPHA;
   INSULIN-RESISTANCE; CARDIOVASCULAR-DISEASE; OXIDATIVE STRESS;
   ESSENTIAL-HYPERTENSION; MYOCARDIAL FIBROSIS
AB In the view of the relationships between excessive sodium intake, immunity and target organ damage, we hypothesized that reduction in dietary sodium would be beneficial in the prevention of cardiac alterations through a restrained local immunity response in a rat model of metabolic syndrome. Sprague-Dawley rats were fed a 60% fructose diet with either a normal sodium (0.64% NaCl) or a low sodium content (<0.01% NaCl) for 8 weeks. After 4 weeks, rats were infused or not with angiotensin II (200 ng.kg(-1).min(-1), sc) for 4 weeks. Tail-cuff blood pressure was determined in conscious rats. Heart and left ventricle weight, cardiomyocyte size, and cardiac fibrosis were evaluated. We performed a transcriptomic analysis in order to identify differentially regulated cardiac mRNAs between normal and low sodium diets. We validated those results using OCR and immunohistochemistry.
   Angiotensin II-induced blood pressure rise was blunted (similar to 50%) in the low-sodium fed rats while cardiac hypertrophy and fibrosis were prevented. Transcriptomic analysis revealed 66 differentially regulated genes including 13 downregulated genes under the low sodium diet and implicated in the innate immune response. This was confirmed by reduced cardiac macrophages infiltration under the low sodium diet.
   Dietary sodium restriction prevents structural alterations of the heart of rats with fructose-induced insulin resistance and angiotensin II-hypertension. The reduction of cardiac inflammation and macrophage infiltration suggests that innate immunity has an important role in the beneficial effect of sodium restriction on cardiac remodeling. (C) 2017 Elsevier B.V. All rights reserved.
C1 [Jover, Bernard] Montpellier Univ, INSERM, U1046, CNRS,UMR 91214, Montpellier, France.
   [Reynes, Christelle] Montpellier Univ, Inst Funct Genom, CNRS, UMR5203,INSERM,U1191, Montpellier, France.
   [Reynes, Christelle] Montpellier Univ, Lab Biostat Informat & Pharmaceut Phys, Montpellier, France.
   [Rugale, Caroline; Jeanson, Laura; Tournier, Michel; Lajoix, Anne Dominique; Desmetz, Caroline] Montpellier Univ, BioCommun CardioMetab BC2M, Montpellier, France.
   [Reboul, Cyril] Avignon Univ, LaPEC EA4278, Avignon, France.
C3 Universite de Montpellier; Institut National de la Sante et de la
   Recherche Medicale (Inserm); Centre National de la Recherche
   Scientifique (CNRS); Universite de Montpellier; Centre National de la
   Recherche Scientifique (CNRS); CNRS - National Institute for Biology
   (INSB); Institut National de la Sante et de la Recherche Medicale
   (Inserm); Universite de Montpellier; Universite de Montpellier; Avignon
   Universite
RP Jover, B (corresponding author), IURC, INSERM, U1046, 641 Ave Doyen GIRAUD, F-34093 Montpellier 5, France.
EM bernard.jover@inserm.fr
RI Desmetz, Caroline/N-4892-2016
OI reboul, cyril/0000-0001-5181-3827; JOVER, Bernard/0000-0001-5826-5755
FU La Fondation de Recherche sur l'Hypertension Arterielle [PR-0708-04A];
   Ministere de l'Education Nationale de l'Enseignement Superieur et de la
   Recherche [RS15]
FX This research was supported by La Fondation de Recherche sur
   l'Hypertension Arterielle (grant no. PR-0708-04A) and by the Ministere
   de l'Education Nationale de l'Enseignement Superieur et de la Recherche
   (grant no. RS15).
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NR 50
TC 6
Z9 6
U1 0
U2 6
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0925-4439
EI 0006-3002
J9 BBA-MOL BASIS DIS
JI Biochim. Biophys. Acta-Mol. Basis Dis.
PD JUN
PY 2017
VL 1863
IS 6
BP 1568
EP 1574
DI 10.1016/j.bbadis.2017.02.026
PG 7
WC Biochemistry & Molecular Biology; Biophysics; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Cell Biology
GA EZ4TE
UT WOS:000404704600039
PM 28254494
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Wu, Y
   Yue, B
   Liu, J
AF Wu, Yu
   Yue, Bin
   Liu, Jia
TI Lipopolysaccharide-induced cytokine expression pattern in peripheral
   blood mononuclear cells in childhood obesity
SO MOLECULAR MEDICINE REPORTS
LA English
DT Article
DE peripheral blood mononuclear cells; childhood-obesity; interleukin-2;
   interleukin-6; tumor necrosis factor-alpha; interferon-alpha;
   interferon-gamma
ID MUSCLE PROTEIN-SYNTHESIS; METABOLIC SYNDROME; LIPOPROTEIN CHOLESTEROL;
   INSULIN-RESISTANCE; FAMILY CYTOKINES; NITRIC-OXIDE; INTERFERON;
   INFECTION; CHILDREN; RECEPTOR
AB Obesity is characterized by the abnormal or excessive fat accumulation that may impair health and extensive increase in body mass index (BMI). Childhood obesity may occur due to disturbances in metabolic regulation, which lead to metabolic syndrome and other diseases. Peripheral blood suspended immune cells are responsible for immune surveillance. The aim of the present study was to map the inflammatory cytokine expression pattern of isolated peripheral blood mononuclear cells (PBMCs) following lipopolysaccharide (LPS) stress in vitro and clinical chemistry parameters in the plasma of subjects. PBMCs were isolated through density gradient ultracentrifugation of the blood from obese infants that would reflect the cytokine response. Isolated PBMCs were cultured in vitro in RPMI-1640 medium and stressed with 1 mu g LPS in order to investigate the expression pattern of cytokines, such as interleukin (IL)-2, interferon (IFN)-gamma, IFN-alpha, tumor necrosis factor-alpha and IL-6 using enzyme-linked immunosorbent assays and reverse transcription-quantitative polymerase chain reaction. Levels of NO, lipid levels, total protein, albumin, marker enzymes aspartate transaminase and alanine transaminase, malondialdehyde (MDA), and reduced glutathione in the plasma were detected. Reduction in the expression of the inflammatory cytokines in PBMCs, reduced protein and globulins, and altered MDA and GSH levels in the plasma were observed. Altered or compromised pro-inflammatory signals from PBMCs in vitro and the clinical chemistry parameters of the plasma suggested that there were compromised immunological responses in obese children compared with matched controls.
C1 [Wu, Yu; Yue, Bin; Liu, Jia] Cangzhou Cent Hosp, Dept Pediat, 201 Xinhua Middle Rd, Cangzhou 061001, Hebei, Peoples R China.
RP Wu, Y (corresponding author), Cangzhou Cent Hosp, Dept Pediat, 201 Xinhua Middle Rd, Cangzhou 061001, Hebei, Peoples R China.
EM yuwu5639@gmail.com
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NR 56
TC 7
Z9 8
U1 0
U2 2
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1791-2997
EI 1791-3004
J9 MOL MED REP
JI Mol. Med. Rep.
PD DEC
PY 2016
VL 14
IS 6
BP 5281
EP 5287
DI 10.3892/mmr.2016.5866
PN A
PG 7
WC Oncology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Research & Experimental Medicine
GA EG5HY
UT WOS:000391076100046
PM 27779667
OA Bronze
DA 2025-06-11
ER

PT J
AU Limberg, JK
   Johansson, RE
   McBride, PE
   Schrage, WG
AF Limberg, Jacqueline K.
   Johansson, Rebecca E.
   McBride, Patrick E.
   Schrage, William G.
TI Increased leg blood flow and improved femoral artery shear patterns in
   metabolic syndrome after a diet and exercise programme
SO CLINICAL PHYSIOLOGY AND FUNCTIONAL IMAGING
LA English
DT Article
DE atherosclerosis; diabetes prevention; forearm; obesity; pre-diabetes
ID CARDIOVASCULAR RISK REDUCTION; ENDOTHELIAL FUNCTION; PHYSICAL-ACTIVITY;
   DYNAMIC EXERCISE; NITRIC-OXIDE; WEIGHT-LOSS; ATHEROSCLEROSIS; RESPONSES;
   PRESSURE; STRESS
AB Background Altered vascular shear profiles may contribute to the development of atherosclerosis. Physical activity promotes anti-atherogenic shear patterns, resulting in reduced cardiovascular disease risk. Adults with metabolic syndrome (MetSyn) are at increased risk of developing atherosclerosis and cardiovascular disease. Thus, we hypothesized that conduit artery antegrade shear rate (ASR) would increase and retrograde shear rate (RSR) and oscillatory shear indices (OSI) would decrease in MetSyn patients (n = 16, 51 +/- 2 years) after participation in a diet and exercise programme (DEP).
   Methods Blood flow (Doppler ultrasound, brachial and femoral arteries) was measured, and shear rates were calculated in MetSyn patients before and after 12 weeks of DEP participation. In addition, plasma samples were collected to measure atherogenic markers.
   Results Diet and exercise programme participation increased resting leg blood flow and femoral artery ASR (P <= 0.05), and tended to decrease OSI (P = 0.09); RSR did not change (P>0.05). No changes in resting arm blood flow or ASR were observed (P>0.05), and both RSR and OSI increased after participation (P <= 0.05). DEP participation reduced plasma vascular cell adhesion molecule(VCAM)-1 (P = 0.03), with a trend for reduced intercellular cell adhesion molecule(ICAM)-1 (P = 0.09) (i.e. atherogenic markers).
   Conclusion Modest changes in diet and physical activity result in limb-specific improvements in vascular shear profiles and reduced systemic markers of atherosclerotic risk in MetSyn patients. These data provide novel physiologic insight into adaptations that may limit the progression of atherosclerosis in patients with MetSyn.
C1 [Limberg, Jacqueline K.; Johansson, Rebecca E.; Schrage, William G.] Univ Wisconsin, Dept Kinesiol, Sch Educ, Madison, WI 53706 USA.
   [McBride, Patrick E.] Univ Wisconsin, Madison Hosp & Clin, Sch Med & Publ Hlth, Dept Cardiol, Madison, WI 53706 USA.
C3 University of Wisconsin System; University of Wisconsin Madison;
   University of Wisconsin System; University of Wisconsin Madison
RP Schrage, WG (corresponding author), Univ Wisconsin, Dept Kinesiol, 2000 Observ Dr,1149A Natatorium, Madison, WI 53706 USA.
EM wschrage@education.wisc.edu
OI Johansson, Rebecca/0000-0002-0605-1293
FU American Heart Association [0815622G, 10PRE3870000]; American Federation
   on Aging Research [A09235]; National Institutes of Health
   [1R01HL105820-01A1, RR000167]; Wisconsin National Primate Research
   Center Assay Services; American Heart Association (AHA) [10PRE3870000,
   0815622G] Funding Source: American Heart Association (AHA)
FX We are grateful to our subjects for their participation. In addition, we
   extend many thanks to Laura Pady-Porter and Vonda Shaw, coordinators of
   the DEP (Active Living and Learning Program), and John Harrell, Trent
   Evans, Molly Dixon, and Jennie Scidmore for technical assistance. This
   study was supported by grants from the American Heart Association
   [#0815622G, #10PRE3870000 (JKL)], American Federation on Aging Research
   [#A09235 (WGS)], National Institutes of Health [#1R01HL105820-01A1
   (WGS)] and Wisconsin National Primate Research Center Assay Services
   with the partial support of Grant RR000167 from the National Institutes
   of Health.
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NR 34
TC 5
Z9 6
U1 0
U2 8
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1475-0961
EI 1475-097X
J9 CLIN PHYSIOL FUNCT I
JI Clin. Physiol. Funct. Imaging
PD JUL
PY 2014
VL 34
IS 4
BP 282
EP 289
DI 10.1111/cpf.12095
PG 8
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA AN4PH
UT WOS:000340569600006
PM 24237709
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Oster, M
   Murani, E
   Metges, CC
   Ponsuksili, S
   Wimmers, K
AF Oster, Michael
   Murani, Eduard
   Metges, Cornelia C.
   Ponsuksili, Siriluck
   Wimmers, Klaus
TI A High Protein Diet during Pregnancy Affects Hepatic Gene Expression of
   Energy Sensing Pathways along Ontogenesis in a Porcine Model
SO PLOS ONE
LA English
DT Article
ID INTRAUTERINE GROWTH-RETARDATION; FOLIC-ACID SUPPLEMENTATION; MATERNAL
   LOW; METABOLIC SYNDROME; RESTRICTION LEADS; MAMMALIAN TARGET; RAPAMYCIN
   MTOR; FETAL-RAT; IGF-I; KINASE
AB In rodent models and in humans the impact of gestational diets on the offspring's phenotype was shown experimentally and epidemiologically. The underlying programming of fetal development was shown to be associated with an increased risk of degenerative diseases in adulthood, including the metabolic syndrome. There are clues that diet-dependent modifications of the metabolism during fetal life can persist until adulthood. This leads to the hypothesis that the offspring's transcriptomes show short-term and long-term changes depending on the maternal diet. To this end pregnant German landrace gilts were fed either a high protein diet (HP, 30% CP) or an adequate protein diet (AP, 12% CP) throughout pregnancy. Hepatic transcriptome profiles of the offspring were analyzed at prenatal (94 dpc) and postnatal stages (1, 28, 188 dpn). Depending on the gestational dietary exposure, mRNA expression levels of genes related to energy metabolism, N-metabolism, growth factor signaling pathways, lipid metabolism, nucleic acid metabolism and stress/immune response were affected either in a short-term or in a long-term manner. Gene expression profiles at fetal stage 94 dpc were almost unchanged between the diets. The gestational HP diet affected the hepatic expression profiles at prenatal and postnatal stages. The effects encompassed a modulation of the genome in terms of an altered responsiveness of energy and nutrient sensing pathways. Differential expression of genes related to energy production and nutrient utilization contribute to the maintenance of development and growth performance within physiological norms, however the modulation of these pathways may be accompanied by a predisposition for metabolic disturbances up to adult stages.
C1 [Oster, Michael; Murani, Eduard; Wimmers, Klaus] Leibniz Inst Farm Anim Biol FBN, Res Unit Mol Biol, Dummerstorf, Germany.
   [Metges, Cornelia C.] Leibniz Inst Farm Anim Biol FBN, Res Unit Physiol Nutr, Dummerstorf, Germany.
   [Ponsuksili, Siriluck] Leibniz Inst Farm Anim Biol FBN, Res Grp Funct Genom, Dummerstorf, Germany.
C3 Forschungsinstitut fur Nutztierbiologie (FBN); Forschungsinstitut fur
   Nutztierbiologie (FBN); Forschungsinstitut fur Nutztierbiologie (FBN)
RP Oster, M (corresponding author), Leibniz Inst Farm Anim Biol FBN, Res Unit Mol Biol, Dummerstorf, Germany.
EM wimmers@fbn-dummerstorf.de
RI Wimmers, Klaus/AAF-9434-2020
OI Wimmers, Klaus/0000-0002-9523-6790
FU German Federal Ministry of Education and Research [FKZ 0315132A]
FX The study is part of the project FEPROeXPRESS (FUGATOplus
   (http://www.fugato-forschung.de/), FKZ 0315132A), which is funded by the
   German Federal Ministry of Education and Research. The funders had no
   role in study design, data collection and analysis, decision to publish,
   or preparation of the manuscript.
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NR 67
TC 18
Z9 19
U1 0
U2 7
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JUL 18
PY 2011
VL 6
IS 7
AR e21691
DI 10.1371/journal.pone.0021691
PG 12
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 793HY
UT WOS:000292812400012
PM 21789176
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Casella, A
   Chagas, ACP
   Maranhao, RC
   Trombetta, IC
   Cesena, FHY
   Silva, VM
   Tanus-Santos, JE
   Negrao, CE
   da Luz, PL
AF Casella-Filho, Antonio
   Chagas, Antonio Carlos P.
   Maranhao, Raul C.
   Trombetta, Ivani C.
   Cesena, Fernando H. Y.
   Silva, Vanessa M.
   Tanus-Santos, Jose Eduardo
   Negrao, Carlos E.
   da Luz, Protasio L.
TI Effect of Exercise Training on Plasma Levels and Functional Properties
   of High-Density Lipoprotein Cholesterol in the Metabolic Syndrome
SO AMERICAN JOURNAL OF CARDIOLOGY
LA English
DT Article
ID ELEVATED OXIDATIVE STRESS; ANTIOXIDATIVE ACTIVITY; DIABETES-MELLITUS;
   HDL; PARTICLES; DISEASE; SERUM
AB Intense lifestyle modifications can change the high-density lipoprotein (HDL) cholesterol concentration. The aim of the present study was to analyze the early effects of short-term exercise training, without any specific diet, on the HDL cholesterol plasma levels and HDL functional characteristics in patients with the metabolic syndrome (MS). We studied 30 sedentary subjects, 20 with and 10 without the MS. The patients with the MS underwent moderate intensity exercise training for 3 months on bicycle ergometers. Blood was sampled before and after training for biochemical analysis, paraoxonase-1 activity, and HDL subfraction composition and antioxidative capacity. Lipid transfer to HDL was assayed in vitro using a labeled nanoemulsion as the lipid donor. At baseline, the MS group had greater triglyceride levels and a lower HDL cholesterol concentration and lower paraoxonase-1 activity than did the controls. Training decreased the plasma triglycerides but did not change the low-density lipoprotein or HDL cholesterol levels. Nonetheless, exercise training increased the HDL subfractions' antioxidative capacity and paraoxonase-1 activity. After training, the MS group had compositional changes in the smallest HDL subfractions associated with increased free cholesterol and cholesterol ester transfers to HDL, reaching normal values. In conclusion, the present investigation has added relevant information about the dissociation between the quantitative and qualitative aspects of HDL after short-term exercise training without any specific diet in those with the MS, highlighting the importance of evaluating the functional aspects of the lipoproteins, in addition to their plasma levels. (C) 2011 Elsevier Inc. All rights reserved. (Am J Cardiol 2011;107:1168-1172)
C1 [Casella-Filho, Antonio; Chagas, Antonio Carlos P.; Maranhao, Raul C.; Trombetta, Ivani C.; Cesena, Fernando H. Y.; Silva, Vanessa M.; Negrao, Carlos E.; da Luz, Protasio L.] Univ Sao Paulo, Sch Med, Heart Inst InCor, Sao Paulo, Brazil.
   [Tanus-Santos, Jose Eduardo] Univ Sao Paulo, Dept Pharmacol, Fac Med Ribeirao Preto, Sao Paulo, Brazil.
C3 Universidade de Sao Paulo; Universidade de Sao Paulo
RP Casella, A (corresponding author), Univ Sao Paulo, Sch Med, Heart Inst InCor, Sao Paulo, Brazil.
EM casella@incor.usp.br
RI Trombetta, Ivani/G-5839-2012; Casella-Filho, Antonio/A-1976-2011;
   Negrao, Carlos/C-4281-2012; Silva, Vanessa M/D-7159-2018; Yue Cesena,
   Fernando/G-1948-2016; Maranhao, Raul/I-5996-2012
OI Silva, Vanessa M/0000-0001-8245-9971; Yue Cesena,
   Fernando/0000-0002-1051-9434; Maranhao, Raul/0000-0003-1520-4914; Da
   Luz, Protasio/0000-0003-2451-5570
FU Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP, Sao Paulo,
   Brazil) [05/58543-3]
FX This study was supported by grant 05/58543-3 from Fundacao de Amparo a
   Pesquisa do Estado de Sao Paulo (FAPESP, Sao Paulo, Brazil).
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NR 20
TC 73
Z9 77
U1 1
U2 16
PU EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
PI BRIDGEWATER
PA 685 ROUTE 202-206 STE 3, BRIDGEWATER, NJ 08807 USA
SN 0002-9149
J9 AM J CARDIOL
JI Am. J. Cardiol.
PD APR 15
PY 2011
VL 107
IS 8
BP 1168
EP 1172
DI 10.1016/j.amjcard.2010.12.014
PG 5
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 752OQ
UT WOS:000289702400011
PM 21310370
OA Bronze
DA 2025-06-11
ER

PT J
AU van Winkel, R
   van Os, J
   Celic, I
   Van Eyck, D
   Wampers, M
   Scheen, A
   Peuskens, J
   De Hert, M
AF van Winkel, Ruud
   van Os, Jim
   Celic, Ivan
   Van Eyck, Dominique
   Wampers, Martien
   Scheen, Andre
   Peuskens, Joseph
   De Hert, Marc
TI Psychiatric diagnosis as an independent risk factor for metabolic
   disturbances: Results from a comprehensive, naturalistic screening
   program
SO JOURNAL OF CLINICAL PSYCHIATRY
LA English
DT Article
ID ATYPICAL ANTIPSYCHOTIC MEDICATION; DRUG-NAIVE PATIENTS; DAILY-LIFE
   STRESS; BIPOLAR-DISORDER; SCHIZOAFFECTIVE DISORDER; EMOTIONAL
   REACTIVITY; GLUCOSE-TOLERANCE; DIABETES-MELLITUS; SCHIZOPHRENIA;
   PREVALENCE
AB Objective: Unconfounded differences in inherent vulnerability to metabolic disturbance may be hypothesized for different diagnostic groups with severe mental illness.
   Method: A naturalistic cohort of patients diagnosed with DSM-IV bipolar disorder (N = 112), schizophrenia (N = 503), and schizoaffective disorder (N = 92) were assessed for metabolic disturbances. The prospective inclusions started in November 2003 and were concluded in July 2007.
   Results: Diagnosis was strongly associated with the metabolic syndrome (chi(2) = 14.90, df = 2, p < .001). Compared with bipolar patients, the unadjusted risk for metabolic syndrome was significantly higher for schizoaffective (odds ratio [OR] = 3.51, p < .0001) but not for schizophrenia patients (OR = 1.58, p = .094). Differences were not reducible to confounding factors including treatment. Rather. the difference between bipolar and schizophrenia patients also reached significance after adjustment (OR = 1.97, p = .046). Furthermore, the association between diagnosis and glucose dysregulation was significant chi(2) = 6.97, df = 2, p = .031), with a significantly higher risk in schizoaffective (unadjusted OR = 2.12, p = .022) but not in schizophrenia patients (unadjusted OR = 1.13, p = .640) compared with bipolar patients. Diagnostic differences in glucose dysregulation were in part mediated by body mass index (BMI).
   Conclusions: Schizoaffective patients in particular may be at risk for metabolic disturbances compared with bipolar and schizophrenia patients. Differences were not reducible to known metabolic risk factors and could only be explained in part by higher BMI in schizoaffective patients, suggesting an increased inherent vulnerability in this group.
C1 [van Winkel, Ruud; Van Eyck, Dominique; Wampers, Martien; Peuskens, Joseph; De Hert, Marc] Catholic Univ Louvain, Univ Psychiat Ctr, B-3070 Kortenberg, Belgium.
   [van Winkel, Ruud; van Os, Jim] Maastricht Univ, Dept Psychiat & Neuropsychol, EURON, S Limburg Mental Hlth Res & Teaching Network, Maastricht, Netherlands.
   [Celic, Ivan] Vrapce Psychiat Hosp, Univ Dept Gen & Foreens Psychiat, Zagreb, Croatia.
   [Scheen, Andre] Univ Liege, Dept Diabetes & Metab Disorders, CHU Sart Tilman, B-4000 Liege, Belgium.
C3 Universite Catholique Louvain; Maastricht University; University of
   Liege
RP van Winkel, R (corresponding author), Catholic Univ Louvain, Univ Psychiat Ctr, Leuvensesteenweg 517, B-3070 Kortenberg, Belgium.
EM ruud.van.winkel@uc-kortenberg.de
RI De Hert, Marc/AAH-6090-2021; van Os, Jim/V-8884-2019; van Winkel,
   Ruud/B-9486-2008
OI De Hert, Marc/0000-0003-4255-5920; van Winkel, Ruud/0000-0001-6262-1935;
   van Os, Jim/0000-0002-7245-1586
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NR 44
TC 60
Z9 63
U1 0
U2 12
PU PHYSICIANS POSTGRADUATE PRESS
PI MEMPHIS
PA P O BOX 752870, MEMPHIS, TN 38175-2870 USA
SN 0160-6689
EI 1555-2101
J9 J CLIN PSYCHIAT
JI J. Clin. Psychiatry
PD AUG
PY 2008
VL 69
IS 8
BP 1319
EP 1327
DI 10.4088/JCP.v69n0817
PG 11
WC Psychology, Clinical; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA 339VF
UT WOS:000258604700020
PM 18681750
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Cao, QQ
   Xu, DM
   Chen, Y
   Long, YM
   Dai, F
   Gui, L
   Lu, YX
AF Cao, Qiongqiong
   Xu, Dongmei
   Chen, Yong
   Long, Yueming
   Dai, Fang
   Gui, Li
   Lu, Yunxia
TI Sitagliptin Reduces Endothelial Dysfunction and Apoptosis Induced by
   High-Fat Diet and Palmitate in Thoracic Aortas and Endothelial Cells via
   ROS-ER Stress-CHOP Pathway
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Article
DE sitagliptin; high-fat diet; palmitate; endoplasmic reticulum stress;
   thoracic aorta; human umbilical vein endothelial cells; ROS
ID DIPEPTIDYL PEPTIDASE-4 INHIBITOR; GLYCEMIC CONTROL; PROTECTS; INSULIN;
   MICE; INFLAMMATION; OBESITY
AB Macrovascular disease is tightly associated with obesity-induced metabolic syndrome. Sitagliptin (SIT), an orally stable selective inhibitor of Dipeptidyl peptidase-4 (DPP-4), has protective effects on endothelium. However, the mechanisms enabling SIT to exhibit resistance to diet-induced obesity (DIO) related with reactive oxygen species (ROS) and endoplasmic reticulum (ER) stress in the aorta and endothelial cells have not been reported yet. Therefore, the present study was conducted to determine if SIT exerts protective role in the thoracic aortas isolated from the high-fat diet (HFD)-treated rats and palmitate (PA)-treated endothelial cells by alleviating ROS and ER stress. Male Sprague Dawley rats were randomly divided into standard chow diet (SCD), HFD and HFD plus sitagliptin administration (HFD + SIT) groups. The rats of latter two groups were given HFD fodder for 12 weeks, then the HFD + SIT rats were treated with SIT (10 mg/kg/d) by intragastric administration for another 8 weeks. The body mass, vascular tension, serum oxidative stress indices and inflammatory parameters, pathological changes, protein expression of endothelial nitric oxide synthase (eNOS), the genes associated with ER stress and apoptosis in the thoracic aorta were measured. Furthermore, cell proliferation, ROS and the protein expression associated with ER stress (especially CHOP) and apoptosis were assessed in human umbilical vein endothelial cells (HUVECs) incubated with SIT and PA. Compared to the SCD rats, the HFD rats had higher serum lipid levels, decreased vascular tension, increased inflammation, oxidative and ER stress, and apoptosis of endothelial cells. PA promoted ROS generation, ER stress and apoptosis, inhibited cell proliferation in HUVECs. SIT treatment obviously ameliorated apoptosis via alleviating ROS and ER stress in the thoracic aortas isolated from HFD-fed rats and PA-treated HUVECs. The results suggest that SIT improved endothelial function via promoting cell proliferation and alleviating ROS-ER stress-CHOP pathway both in vivo and in vitro.</p>
C1 [Cao, Qiongqiong; Xu, Dongmei; Long, Yueming; Lu, Yunxia] Dept Biochem & Mol Biol, Hefei, Peoples R China.
   [Chen, Yong] Hefei Lifeon Pharmaceut Co Ltd, Hefei, Peoples R China.
   [Dai, Fang] Anhui Med Univ, Dept Endocrinol, Affiliated Hosp 1, Hefei, Peoples R China.
   [Gui, Li; Lu, Yunxia] Anhui Med Univ, Sch Basic Med Sci, Comprehens Lab, Hefei, Peoples R China.
C3 Anhui Medical University; Anhui Medical University
RP Lu, YX (corresponding author), Dept Biochem & Mol Biol, Hefei, Peoples R China.; Lu, YX (corresponding author), Anhui Med Univ, Sch Basic Med Sci, Comprehens Lab, Hefei, Peoples R China.
EM luyunxia@ahmu.edu.cn
RI gui, li/GQQ-2739-2022; Lu, Yunxia/AAU-6408-2021
FU Natural Science Foundation of Anhui Province in China [1808085MH233]
FX This study was supported by the Natural Science Foundation of Anhui
   Province in China (1808085MH233).
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NR 36
TC 19
Z9 19
U1 2
U2 10
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD AUG 31
PY 2021
VL 12
AR 670389
DI 10.3389/fphar.2021.670389
PG 14
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA US6RE
UT WOS:000697553100001
PM 34531738
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Tu, Z
   Yang, JF
   Fan, CM
AF Tu, Zhi
   Yang, Jinfu
   Fan, Chengming
TI The role of different nutrients in the prevention and treatment of
   cardiovascular diseases
SO FRONTIERS IN IMMUNOLOGY
LA English
DT Review
DE cardiovascular disease; nutrient; diet; antioxidant; omega-3 fat acid;
   fibre; antioxidants
ID CORONARY-HEART-DISEASE; POLYUNSATURATED FATTY-ACIDS; OXIDATIVE STRESS;
   FOLIC-ACID; VITAMIN-D; DIETARY FIBER; RISK-FACTORS; EICOSAPENTAENOIC
   ACID; METABOLIC SYNDROME; LOW-CARBOHYDRATE
AB Cardiovascular health is a hot topic around the world, and as the incidence of cardiovascular disease increases each year, people are increasingly focusing on the management of their heart health. Dietary and lifestyle changes as non-pharmacological treatments have been increasingly recognized as important in the prevention of cardiovascular disease and in reducing the risk of cardiovascular accidents. Awareness of different nutrients and their effects on cardiovascular health is important for establishing a good dietary pattern. This review summarizes the effects of the five major nutrients in the daily diet, namely carbohydrates, proteins, dietary fats, vitamins, and minerals, on cardiovascular health, and aims to provide a more comprehensive understanding of the effects of a healthy dietary pattern on cardiovascular health.
C1 [Tu, Zhi; Yang, Jinfu; Fan, Chengming] Cent South Univ, Xiangya Hosp 2, Dept Cardiovasc Surg, Changsha, Peoples R China.
C3 Central South University
RP Fan, CM (corresponding author), Cent South Univ, Xiangya Hosp 2, Dept Cardiovasc Surg, Changsha, Peoples R China.
EM fanchengming@csu.edu.cn
RI Fan, Chengming/HDM-1071-2022
FU Science and Technology Innovation Program of Hunan Province [2021RC2106,
   2023SK2031]; Natural Science Foundation of Hunan Province [2022JJ20088,
   2023JJ30793]; National Natural Science Foundation of China [82200323];
   Scientific Research Launch Project for new employees of the Second
   Xiangya Hospital of Central South University
FX The author(s) declare financial support was received for the research,
   authorship, and/or publication of this article. This work was
   financially supported by the Science and Technology Innovation Program
   of Hunan Province (2021RC2106 to CF, 2023SK2031 to JY), the Natural
   Science Foundation of Hunan Province (2022JJ20088 to CF, 2023JJ30793 to
   JY), the National Natural Science Foundation of China (82200323 to CF),
   and the Scientific Research Launch Project for new employees of the
   Second Xiangya Hospital of Central South University (to CF).
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NR 167
TC 1
Z9 1
U1 7
U2 16
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-3224
J9 FRONT IMMUNOL
JI Front. Immunol.
PD MAY 10
PY 2024
VL 15
AR 1393378
DI 10.3389/fimmu.2024.1393378
PG 15
WC Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology
GA RT3C0
UT WOS:001229861500001
PM 38799425
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Singeap, AM
   Stanciu, C
   Huiban, L
   Muzica, CM
   Cuciureanu, T
   Girleanu, I
   Chiriac, S
   Zenovia, S
   Nastasa, R
   Sfarti, C
   Cojocariu, C
   Trifan, A
AF Singeap, Ana-Maria
   Stanciu, Carol
   Huiban, Laura
   Muzica, Cristina Maria
   Cuciureanu, Tudor
   Girleanu, Irina
   Chiriac, Stefan
   Zenovia, Sebastian
   Nastasa, Robert
   Sfarti, Catalin
   Cojocariu, Camelia
   Trifan, Anca
TI Association between Nonalcoholic Fatty Liver Disease and
   Endocrinopathies: Clinical Implications
SO CANADIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
LA English
DT Review
ID POLYCYSTIC-OVARY-SYNDROME; 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1;
   GROWTH-HORMONE REPLACEMENT; INSULIN-RESISTANCE; HEPATIC STEATOSIS;
   METABOLIC SYNDROME; OXIDATIVE STRESS; LOW TESTOSTERONE; GH REPLACEMENT;
   UNITED-STATES
AB Nonalcoholic fatty liver disease (NAFLD) has a rising prevalence worldwide. Its potential for evolution towards liver cirrhosis and hepatocellular carcinoma, as well as associations with extrahepatic manifestations, represents a double burden for patients and physicians alike. Recently, there has been increasing evidence of the association between NAFLD and a number of endocrinopathies, such as hypothyroidism, polycystic ovarian syndrome (PCOS), hypopituitarism, growth hormone deficiency (GHD), hypogonadism, and hypercortisolism. Definite correlations are supported by clear evidence so far, but further studies are needed in order to completely clarify the pathogenic mechanisms and, especially, to identify therapeutic implications. In this review, we present the main relationships between NAFLD and endocrinopathies, emphasizing the reciprocal causality, evolutive interconnections, and current clinical scenarios of presentations of which the clinicians should be aware.
C1 [Singeap, Ana-Maria; Huiban, Laura; Muzica, Cristina Maria; Cuciureanu, Tudor; Girleanu, Irina; Chiriac, Stefan; Zenovia, Sebastian; Nastasa, Robert; Sfarti, Catalin; Cojocariu, Camelia; Trifan, Anca] Grigore T Popa Univ Med & Pharm, Dept Gastroenterol, Iasi 700115, Romania.
   [Singeap, Ana-Maria; Stanciu, Carol; Huiban, Laura; Muzica, Cristina Maria; Cuciureanu, Tudor; Girleanu, Irina; Chiriac, Stefan; Zenovia, Sebastian; Nastasa, Robert; Sfarti, Catalin; Cojocariu, Camelia; Trifan, Anca] St Spiridon Emergency Hosp, Inst Gastroenterol & Hepatol, Iasi 700111, Romania.
C3 Grigore T Popa University of Medicine & Pharmacy; Grigore T Popa
   University of Medicine & Pharmacy
RP Huiban, L; Cuciureanu, T (corresponding author), Grigore T Popa Univ Med & Pharm, Dept Gastroenterol, Iasi 700115, Romania.; Huiban, L; Cuciureanu, T (corresponding author), St Spiridon Emergency Hosp, Inst Gastroenterol & Hepatol, Iasi 700111, Romania.
EM anamaria.singeap@yahoo.com; stanciucarol@yahoo.com;
   huiban.laura@yahoo.com; lungu.christina@yahoo.com;
   drcuciureanutudor@gmail.com; gilda_iri25@yahoo.com;
   stefannchiriac@yahoo.com; sebastianzenovia20@gmail.com;
   robertnastasa948@gmail.com; cvsfarti@gmail.com;
   cameliacojocariu@yahoo.com; ancatrifan@yahoo.com
RI Girleanu, Irina/MTF-8711-2025; Muzica, Cristina/AAF-6801-2019;
   Cuciureanu, Tudor/MTF-6908-2025; Sebastian, Zenovia/AAS-7256-2020;
   Chiriac, Stefan/MTF-7600-2025; Nastasa, Robert/AAR-6930-2021; Trifan,
   Anca/MTF-7993-2025
OI Nastasa, Robert/0000-0002-8678-0663; Cuciureanu,
   Tudor/0000-0003-1550-8870; Girleanu, Irina/0000-0001-5925-1232; Chiriac,
   Stefan/0000-0003-2497-9236; Sebastian, Zenovia/0000-0003-0441-3980;
   Trifan, Anca/0000-0001-9144-5520; Cristina-Maria,
   Muzica/0000-0003-0891-5961; Singeap, Ana-Maria/0000-0001-5621-548X
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NR 82
TC 17
Z9 18
U1 1
U2 7
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2291-2789
EI 2291-2797
J9 CAN J GASTROENTEROL
JI Can. J. Gastroenterol. Hepatol.
PD JAN 11
PY 2021
VL 2021
AR 6678142
DI 10.1155/2021/6678142
PG 8
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA PZ8RO
UT WOS:000613015600001
PM 33505943
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Colombo, R
   Papetti, A
AF Colombo, Raffaella
   Papetti, Adele
TI Decaffeinated coffee and its benefits on health: focus on systemic
   disorders
SO CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
LA English
DT Review
DE Caffeine; cancer; decaffeinated coffee; inflammation; metabolic
   syndromes; non-caffeine compounds
ID HEPATOCELLULAR-CARCINOMA CELLS; CHLOROGENIC ACID; CAFFEIC ACID;
   ANTIBACTERIAL ACTIVITY; INDUCED APOPTOSIS; ALL-CAUSE; METABOLIC
   SYNDROME; GLUCOSE-TOLERANCE; OXIDATIVE STRESS; ROASTED COFFEE
AB The current literature has mainly focused on benefits and risks deriving from the consumption of caffeinated coffee and its implications for inflammation, cardiovascular diseases, neurodegenerative disorders, and cancer. Today, data about the role of caffeine in many disorders are controversial and the attention has increasingly focused on decaffeinated coffee and its non-caffeine compounds, which could have mainly beneficial effects. In fact, coffee phenolic compounds not only exhibit well-known antioxidant properties, but they can also antagonize some negative effects of caffeine, for example in inflammatory pathway and in glucose metabolism and homeostasis. In this review, we consider the literature of the last two decades and critically discuss the effects of decaffeinated coffee compounds on systemic disorders, mainly inflammation, cardiovascular diseases, hepatic dysfunctions, and cancer.
C1 [Colombo, Raffaella; Papetti, Adele] Univ Pavia, Dept Drug Sci, Vle Taramelli 12, I-27100 Pavia, Italy.
C3 University of Pavia
RP Papetti, A (corresponding author), Univ Pavia, Dept Drug Sci, Vle Taramelli 12, I-27100 Pavia, Italy.
EM adele.papetti@unipv.it
OI Papetti, Adele/0000-0003-1523-7759; Colombo,
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NR 185
TC 9
Z9 9
U1 1
U2 33
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1040-8398
EI 1549-7852
J9 CRIT REV FOOD SCI
JI Crit. Rev. Food Sci. Nutr.
PD AUG 22
PY 2021
VL 61
IS 15
BP 2506
EP 2522
DI 10.1080/10408398.2020.1779175
EA JUN 2020
PG 17
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA TY2EX
UT WOS:000545773200001
PM 32551832
DA 2025-06-11
ER

PT J
AU Awad, E
   Othman, EM
   Stopper, H
AF Awad, Eman
   Othman, Eman M.
   Stopper, Helga
TI Effects of Resveratrol, Lovastatin and the mTOR-Inhibitor RAD-001 on
   Insulin-Induced Genomic Damage In Vitro
SO MOLECULES
LA English
DT Article
DE insulin; resveratrol; lovastatin; mTOR-inhibitor RAD-001; genomic damage
ID METABOLIC SYNDROME; OXIDATIVE STRESS; SIGNAL-TRANSDUCTION;
   DIABETES-MELLITUS; CELL CARCINOMA; BREAST-CANCER; COLON-CANCER;
   DNA-DAMAGE; MITOCHONDRIA; HYPERINSULINEMIA
AB Diabetes mellitus (DM) is one of the major current health problems due to lifestyle changes. Before diagnosis and in the early years of disease, insulin blood levels are elevated. However, insulin generates low levels of reactive oxygen species (ROS) which are integral to the regulation of a variety of intracellular signaling pathways, but excess levels of insulin may also lead to DNA oxidation and DNA damage. Three pharmaceutical compounds, resveratrol, lovastatin and the mTOR-inhibitor RAD-001, were investigated due to their known beneficial effects. They showed protective properties against genotoxic damage and significantly reduced ROS after in vitro treatment of cultured cells with insulin. Therefore, the selected pharmaceuticals may be attractive candidates to be considered for support of DM therapy.
C1 [Awad, Eman; Othman, Eman M.; Stopper, Helga] Univ Wurzburg, Inst Pharmacol & Toxicol, D-97078 Wurzburg, Germany.
   [Othman, Eman M.] Univ Minia, Dept Analyt Chem, Fac Pharm, Al Minya 11432, Egypt.
C3 University of Wurzburg; Egyptian Knowledge Bank (EKB); Minia University
RP Stopper, H (corresponding author), Univ Wurzburg, Inst Pharmacol & Toxicol, D-97078 Wurzburg, Germany.
EM eman.awad@uni-wuerzburg.de; eman@toxi.uni-wuerzburg.de;
   stopper@toxi.uni-wuerzburg.de
RI Othman, Eman/LBI-5240-2024
OI Othman, Eman M./0000-0003-4781-9745
FU German Research Foundation (DFG); University of Wurzburg
FX We thank Silvana Wunram and Simon Zobus for their expert technical
   assistance. This publication was funded by the German Research
   Foundation (DFG) and the University of Wurzburg in the funding program
   Open Access Publishing.
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NR 59
TC 4
Z9 4
U1 0
U2 1
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1420-3049
J9 MOLECULES
JI Molecules
PD DEC
PY 2017
VL 22
IS 12
AR 2207
DI 10.3390/molecules22122207
PG 12
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA FR7IW
UT WOS:000419242400172
PM 29231877
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Vodo, S
   Bechi, N
   Petroni, A
   Muscoli, C
   Aloisi, AM
AF Vodo, Stella
   Bechi, Nicoletta
   Petroni, Anna
   Muscoli, Carolina
   Aloisi, Anna Maria
TI Testosterone-Induced Effects on Lipids and Inflammation
SO MEDIATORS OF INFLAMMATION
LA English
DT Review
ID DENSITY-LIPOPROTEIN CHOLESTEROL; NECROSIS-FACTOR-ALPHA; KAPPA-B
   ACTIVATION; VITAMIN-D; SUPEROXIDE-DISMUTASE; METABOLIC SYNDROME;
   OXIDATIVE STRESS; REPLACEMENT THERAPY; PROSTATE-CANCER; REACTIVE OXYGEN
AB Chronic pain has to be considered in all respects a debilitating disease and 10-20% of the world's adult population is affected by this disease. In the most general terms, pain is symptomatic of some form of dysfunction and (often) the resulting inflammatory processes in the body. In the study of pain, great attention has been paid to the possible involvement of gonadal hormones, especially in recent years. In particular, testosterone, the main androgen, is thought to play a beneficial, protective role in the body. Other important elements to be related to pain, inflammation, and hormones are lipids, heterogenic molecules whose altered metabolism is often accompanied by the release of interleukins, and lipid-derived proinflammatory mediators. Here we report data on interactions often not considered in chronic pain mechanisms.
C1 [Vodo, Stella; Bechi, Nicoletta; Aloisi, Anna Maria] Univ Siena, Dept Med Surg & Neurosci, I-53100 Siena, Italy.
   [Petroni, Anna] Univ Milan, Dept Pharmacol & Biomol Sci, I-20133 Milan, Italy.
   [Muscoli, Carolina] Magna Graecia Univ Catanzaro, Dept Hlth Sci, I-00163 Rome, Italy.
   [Muscoli, Carolina] IRCCS San Raffaele Pisana, Drug Ctr, I-00163 Rome, Italy.
C3 University of Siena; University of Milan; Magna Graecia University of
   Catanzaro; IRCCS San Raffaele Pisana
RP Aloisi, AM (corresponding author), Univ Siena, Dept Med Surg & Neurosci, Via Aldo Moro 2, I-53100 Siena, Italy.
EM aloisi@unisi.it
RI Aloisi, Anna/AAV-7384-2021; Muscoli, Carolina/G-2773-2011
OI Muscoli, Carolina/0000-0002-1047-4467
FU MIUR (PRIN 2008); University of Siena
FX The authors thank MIUR (PRIN 2008) and University of Siena for funding
   this research.
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NR 91
TC 53
Z9 54
U1 1
U2 11
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 0962-9351
EI 1466-1861
J9 MEDIAT INFLAMM
JI Mediat. Inflamm.
PY 2013
VL 2013
AR 183041
DI 10.1155/2013/183041
PG 8
WC Cell Biology; Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Immunology
GA 124UU
UT WOS:000317494100001
PM 23606790
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Shu, K
   Fu, YC
   Huang, M
   Cai, Z
   Ni, GF
   Huang, XY
   Song, JW
   Ye, XJ
   Cui, SH
   Zhou, YJ
   Han, L
   Wu, P
   Yan, ZH
   Liu, K
AF Shu, Kun
   Fu, Yu-Chuan
   Huang, Mei
   Cai, Zheng
   Ni, Ge-Fei
   Huang, Xiao-Yan
   Song, Jia-Wen
   Ye, Xin-Jian
   Cui, Shi-Han
   Zhou, Yong-Jin
   Han, Lu
   Wu, Peng
   Yan, Zhi-Han
   Liu, Kun
TI Altered Brain Glymphatic Function at Diffusion-Tensor MRI in
   Pre-cirrhotic Metabolic Dysfunction-Associated Fatty Liver Disease
SO ACADEMIC RADIOLOGY
LA English
DT Article
DE MAFLD; Cognition; Glymphatic system; Metabolic syndrome; ALPS
ID OXIDATIVE STRESS; SYSTEM; IMPAIRMENT
AB Rationale and Objectives: To evaluate glymphatic function changes and their relationships with clinical features in patients with metabolic dysfunction-associated fatty liver disease (MAFLD), thereby facilitating early intervention before this disease progresses to cirrhosis. Materials and Methods: A cross-sectional cohort of 46 pre-cirrhotic MAFLD patients and 30 age-, sex-, and education-matched controls was enrolled, with diffusion-tensor imaging (DTI) data, laboratory and neurocognitive scores collected. The DTI analysis along the perivascular space (DTI-ALPS) index was computed for qualifying glymphatic function. Generalized linear model and partial correlation analyses were applied to evaluate relationships between the ALPS index and clinical variables. Results: MAFLD group exhibited a decreased ALPS index and increased diffusivity along the y-axis in the projection fiber compared to the controls. The altered ALPS index was associated with clock drawing test (CDT) score (3.931 [0.914, 6.947], P = 0.011) and was correlated with diastolic pressure level (r = -0.315, P = 0.033) in MAFLD group. The relationships of ALPS index with CDT score (6.263 [2.069, 10.458], P = 0.003) and diastolic pressure level (r = -0.518, P = 0.014) remained in the MAFLD with metabolic syndrome (MetS) group. Furthermore, the ALPS index was even associated with Auditory Verbal Learning Test-Immediate recall score (-23.853 [-45.417, -2.289], P = 0.030) in MAFLD with MetS group. Conclusion: MAFLD patients may have a glymphatic dysfunction prior to cirrhosis, and this alteration may be related to cognition and diastolic pressure. Glymphatic dysfunction has a more severe impact on cognition when MAFLD patient is accompanied by MetS.
C1 [Shu, Kun; Fu, Yu-Chuan; Huang, Mei; Cai, Zheng; Ni, Ge-Fei; Huang, Xiao-Yan; Song, Jia-Wen; Ye, Xin-Jian; Cui, Shi-Han; Zhou, Yong-Jin; Yan, Zhi-Han; Liu, Kun] Wenzhou Med Univ, Affiliated Hosp 2, Dept Radiol, Wenzhou, Peoples R China.
   [Shu, Kun; Fu, Yu-Chuan; Huang, Mei; Cai, Zheng; Ni, Ge-Fei; Huang, Xiao-Yan; Song, Jia-Wen; Ye, Xin-Jian; Cui, Shi-Han; Zhou, Yong-Jin; Yan, Zhi-Han; Liu, Kun] Wenzhou Med Univ, Yuying Childrens Hosp, Wenzhou, Peoples R China.
   [Han, Lu; Wu, Peng] Philips Healthcare, Shanghai, Peoples R China.
C3 Wenzhou Medical University; Wenzhou Medical University; Philips; Philips
   Healthcare
RP Liu, K (corresponding author), Wenzhou Med Univ, Affiliated Hosp 2, Dept Radiol, Wenzhou, Peoples R China.; Liu, K (corresponding author), Wenzhou Med Univ, Yuying Childrens Hosp, Wenzhou, Peoples R China.
EM liukun040954@163.com
RI Cui, Shihan/LTE-7555-2024; xiaoyan, huang/GXM-8130-2022
FU Zhejiang Provincial Natural Science Foundation [LY18H070003,
   LY19H180003]; National Natural Science Foundation of China [82071902];
   Wenzhou Science and Technology Bureau [Y20220066]
FX This work was supported by the grants from Zhejiang Provincial Natural
   Science Foundation (LY18H070003 and LY19H180003) , National Natural
   Science Foundation of China (82071902) , and Wenzhou Science and
   Technology Bureau (No. Y20220066) .
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NR 37
TC 1
Z9 1
U1 1
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1076-6332
EI 1878-4046
J9 ACAD RADIOL
JI Acad. Radiol.
PD DEC
PY 2024
VL 31
IS 12
BP 4946
EP 4954
DI 10.1016/j.acra.2024.06.022
EA NOV 2024
PG 9
WC Radiology, Nuclear Medicine & Medical Imaging
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Radiology, Nuclear Medicine & Medical Imaging
GA O0B9I
UT WOS:001367892400001
PM 38955593
DA 2025-06-11
ER

PT J
AU Wolosowicz, M
   Prokopiuk, S
   Kaminski, TW
AF Wolosowicz, Marta
   Prokopiuk, Slawomir
   Kaminski, Tomasz W.
TI Recent Advances in the Treatment of Insulin Resistance Targeting
   Molecular and Metabolic Pathways: Fighting a Losing Battle?
SO MEDICINA-LITHUANIA
LA English
DT Review
DE insulin resistance; type 2 diabetes; glucose metabolism; obesity;
   metabolic syndrome
ID FATTY LIVER-DISEASE; DIABETES-MELLITUS; MOUSE MODEL; OBESITY; DIET;
   HYPERTENSION; ACTIVATION; ACID; PATTERN; PROTEIN
AB Diabetes Mellitus (DM) is amongst the most notable causes of years of life lost worldwide and its prevalence increases perpetually. The disease is characterized as multisystemic dysfunctions attributed to hyperglycemia resulting directly from insulin resistance (IR), inadequate insulin secretion, or enormous glucagon secretion. Insulin is a highly anabolic peptide hormone that regulates blood glucose levels by hastening cellular glucose uptake as well as controlling carbohydrate, protein, and lipid metabolism. In the course of Type 2 Diabetes Mellitus (T2DM), which accounts for nearly 90% of all cases of diabetes, the insulin response is inadequate, and this condition is defined as Insulin Resistance. IR sequela include, but are not limited to, hyperglycemia, cardiovascular system impairment, chronic inflammation, disbalance in oxidative stress status, and metabolic syndrome occurrence. Despite the substantial progress in understanding the molecular and metabolic pathways accounting for injurious effects of IR towards multiple body organs, IR still is recognized as a ferocious enigma. The number of widely available therapeutic approaches is growing, however, the demand for precise, safe, and effective therapy is also increasing. A literature search was carried out using the MEDLINE/PubMed, Google Scholar, SCOPUS and Clinical Trials Registry databases with a combination of keywords and MeSH terms, and papers published from February 2021 to March 2022 were selected as recently published papers. This review paper aims to provide critical, concise, but comprehensive insights into the advances in the treatment of IR that were achieved in the last months.
C1 [Wolosowicz, Marta] Med Univ Bialystok, Dept Physiol, PL-15222 Bialystok, Poland.
   [Prokopiuk, Slawomir] Lomza State Univ Appl Sci, Fac Hlth Sci, PL-18400 Lomza, Poland.
   [Kaminski, Tomasz W.] Univ Pittsburgh, Dept Med, Pittsburgh Heart Lung & Blood Vasc Med Inst, 930 Scaife Hall, Pittsburgh, PA 15260 USA.
C3 Medical University of Bialystok; Pennsylvania Commonwealth System of
   Higher Education (PCSHE); University of Pittsburgh
RP Kaminski, TW (corresponding author), Univ Pittsburgh, Dept Med, Pittsburgh Heart Lung & Blood Vasc Med Inst, 930 Scaife Hall, Pittsburgh, PA 15260 USA.
EM marta.wolosowicz@umb.edu.pl; sprokopiuk@ansl.edu.pl; kamins1@pitt.edu
RI Kaminski, Tomasz/AAQ-4038-2020; Wolosowicz, Marta/GYJ-7174-2022;
   Prokopiuk, Slawomir/KFA-9139-2024
OI Wolosowicz, Marta/0000-0002-9856-5127; Kaminski,
   Tomasz/0000-0002-8688-4171
FU Medical University of Bialystok [SUB/1/DN/22/001/1118]
FX Figures were created by M.W. using Biorender.com under BioRender
   license. This research was supported by the Medical University of
   Bialystok, grant No. SUB/1/DN/22/001/1118.
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NR 167
TC 34
Z9 37
U1 2
U2 20
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1010-660X
EI 1648-9144
J9 MEDICINA-LITHUANIA
JI Med. Lith.
PD APR
PY 2022
VL 58
IS 4
AR 472
DI 10.3390/medicina58040472
PG 23
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 0S4PR
UT WOS:000786257900001
PM 35454311
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Tabani, K
   Birem, Z
   Halzoune, H
   Saiah, W
   Lahfa, F
   Koceir, EA
   Omari, N
AF Tabani, Khadidja
   Birem, Zahia
   Halzoune, Hanane
   Saiah, Wassila
   Lahfa, Farid
   Koceir, Elhadj Ahmed
   Omari, Naima
TI Therapeutic effect of alkaloids and glycosides of colocynth seeds on
   liver injury, associated with metabolic syndrome in wistar rats, subject
   to nutritional stress
SO PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES
LA English
DT Article
DE High-fat diet; metabolic syndrome; Citrullus colocynthis; glycosides;
   alkaloids
ID HIGH-FAT DIET; INSULIN-RESISTANCE; ACTIVATION; PALM; L.
AB The Citrullus colocynthis, commonly called colocynth, is known because of its purgative effects and whose seeds are commonly used as certain diseases treatment, namely liver diseases, in the Mediterranean countries traditional medicine. This study aims to analyze the effect of two colocynth extracts << glycosides >> and << alkaloids >> on metabolic and histological disorders associated with liver function in Wistar rats (Rattus norvegicus). This pathology is due to an enriched oil palm diet. For this purpose, Wistar male rats n = 18, weighing between 130g and 150g, are divided into two lots. A control group (C) n = 6, receives a standard laboratory diet; an experimental group (E) n = 12, receives a standard laboratory diet supplemented with palm oil. After seven months of experimentation, 8 experimental rats were sacrificed for the morphological study and the remaining 12 rats undergo a colocynth treatment (Tr) for eight weeks. They are subdivided into: The first six experimental rats receive a 70mg/kg single intraperitoneal injection of ethanol extract of cucurbitacin glycosides (Glc). The second lot receives a 70mg/kg single intraperitoneal injection of total alkaloids extract (Alc). The animals of (E) group showed hyperglycemia, hyperinsulinemia, hyperlipemia, dyslipoproteinemia, a significant increase of the enzymatic activity of transaminase (AST and ALT) and alkaline phosphatase (ALP). Histological examination of the liver gland shows major damages Non-alcoholic steatohepatitis [NASH]. Treatment with colocynth glycosides and alkaloids reveals a significant improvement at different levels in plasma as well as in tissue. Treatment with colocynth glycosides and alkaloids shows a hypoglycemic effect, lipid-lowering a well as a hepato-protective effect.
C1 [Tabani, Khadidja; Birem, Zahia; Halzoune, Hanane; Saiah, Wassila; Koceir, Elhadj Ahmed; Omari, Naima] Univ Sci & Technol Houari Boumediene, Fac Biol Sci, Lab Bioenerget & Intermediary Metab, Algiers, Algeria.
   [Lahfa, Farid] Univ Tlemcen, Fac SNVSTU, Lab Chemotherapy & Antitumor Immune Response, Tilimsen, Algeria.
C3 University Science & Technology Houari Boumediene; Universite Abou Bekr
   Belkaid
RP Tabani, K (corresponding author), Univ Sci & Technol Houari Boumediene, Fac Biol Sci, Lab Bioenerget & Intermediary Metab, Algiers, Algeria.
EM tabani@hotmail.fr
OI KOCEIR, Elhadj-Ahmed/0000-0003-1345-2535
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   Wu N, 2013, BBA-MOL BASIS DIS, V1832, P1560, DOI 10.1016/j.bbadis.2013.04.024
NR 49
TC 7
Z9 8
U1 0
U2 6
PU UNIV KARACHI
PI KARACHI
PA UNIV CAMPUS, FAC PHARMACY, KARACHI, 75270, PAKISTAN
SN 1011-601X
J9 PAK J PHARM SCI
JI Pak. J. Pharm. Sci.
PD JAN
PY 2018
VL 31
IS 1
SU 1
BP 277
EP 290
PG 14
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA FW3GX
UT WOS:000425195900006
PM 29386155
DA 2025-06-11
ER

PT J
AU Lima, LCF
   Saliba, SW
   Andrade, JMO
   Cunha, ML
   Cassini-Vieira, P
   Feltenberger, JD
   Barcelos, LS
   Guimaraes, ALS
   de-Paula, AMB
   de Oliveira, ACP
   Santos, SHS
AF Freitas Lima, Leandro Ceotto
   Saliba, Soraya Wilke
   Oliveira Andrade, Joao Marcus
   Cunha, Maria Luisa
   Cassini-Vieira, Puebla
   Feltenberger, John David
   Barcelos, Luciola Silva
   Sena Guimaraes, Andre Luiz
   Batista de-Paula, Alfredo Mauricio
   Pinheiro de Oliveira, Antonio Carlos
   Sousa Santos, Sergio Henrique
TI Neurodegeneration Alters Metabolic Profile and Sirt 1 Signaling in
   High-Fat-Induced Obese Mice
SO MOLECULAR NEUROBIOLOGY
LA English
DT Article
DE Huntington's disease; Metabolic syndrome; Quinolinic acid; Sirtuin
ID HUNTINGTONS-DISEASE; QUINOLINIC ACID; MOUSE MODEL; MITOCHONDRIAL
   BIOGENESIS; MUTANT HUNTINGTIN; ENERGY-METABOLISM; OXIDATIVE STRESS;
   ADIPOSE-TISSUE; PGC-1-ALPHA; INFLAMMATION
AB Different factors may contribute to the development of neurodegenerative diseases. Among them, metabolic syndrome (MS), which has reached epidemic proportions, has emerged as a potential element that may be involved in neurodegeneration. Furthermore, studies have shown the importance of the sirtuin family in neuronal survival and MS, which opens the possibility of new pharmacological targets. This study investigates the influence of sirtuin metabolic pathways by examining the functional capacities of glucose-induced obesity in an excitotoxic state induced by a quinolinic acid (QA) animal model. Mice were divided into two groups that received different diets for 8 weeks: one group received a regular diet, and the other group received a high-fat diet (HF) to induce MS. The animals were submitted to a stereotaxic surgery and subdivided into four groups: Standard (ST), Standard-QA (ST-QA), HF and HF-QA. The QA groups were given a 250 nL quinolinic acid injection in the right striatum and PBS was injected in the other groups. Obese mice presented with a weight gain of 40 % more than the ST group beyond acquiring an insulin resistance. QA induced motor impairment and neurodegeneration in both ST-QA and HF-QA, although no difference was observed between these groups. The HF-QA group showed a reduction in adiposity when compared with the groups that received PBS. Therefore, the HF-QA group demonstrated a commitment-dependent metabolic pathway. The results suggest that an obesogenic diet does not aggravate the neurodegeneration induced by QA. However, the excitotoxicity induced by QA promotes a sirtuin pathway impairment that contributes to metabolic changes.
C1 [Freitas Lima, Leandro Ceotto; Sousa Santos, Sergio Henrique] Univ Fed Minas Gerais, Food Engn Coll, Inst Agr Sci, Montes Claros, MG, Brazil.
   [Freitas Lima, Leandro Ceotto; Saliba, Soraya Wilke; Cunha, Maria Luisa; Cassini-Vieira, Puebla; Barcelos, Luciola Silva; Pinheiro de Oliveira, Antonio Carlos] Univ Fed Minas Gerais, Dept Pharmacol, Ave Antonio Carlos 6627, BR-31270901 Belo Horizonte, MG, Brazil.
   [Freitas Lima, Leandro Ceotto; Saliba, Soraya Wilke; Cunha, Maria Luisa; Cassini-Vieira, Puebla; Barcelos, Luciola Silva; Pinheiro de Oliveira, Antonio Carlos] Univ Fed Minas Gerais, Dept Physiol, ICB, Ave Antonio Carlos 6627, BR-31270901 Belo Horizonte, MG, Brazil.
   [Oliveira Andrade, Joao Marcus; Sena Guimaraes, Andre Luiz; Batista de-Paula, Alfredo Mauricio; Sousa Santos, Sergio Henrique] Univ Estadual Montes Claros, Hlth Sci Postgrad Program, Montes Claros, MG, Brazil.
   [Feltenberger, John David] Texas Tech Univ, Lubbock, TX 79409 USA.
C3 Universidade Federal de Minas Gerais; Universidade Federal de Minas
   Gerais; Universidade Federal de Minas Gerais; Universidade Estadual de
   Montes Claros; Texas Tech University System; Texas Tech University
RP Santos, SHS (corresponding author), Univ Fed Minas Gerais, Food Engn Coll, Inst Agr Sci, Montes Claros, MG, Brazil.; Santos, SHS (corresponding author), Univ Estadual Montes Claros, Hlth Sci Postgrad Program, Montes Claros, MG, Brazil.
EM sergiosousas@hotmail.com
RI Andrade, Joao/K-4072-2015; Santos, Sérgio/D-8143-2011; Lima,
   Leandro/I-6425-2012; De Paula, Alfredo/K-3015-2012; Guimaraes,
   Andre/D-8122-2011; Silva Barcelos, Luciola/A-1109-2013; de Oliveira,
   Antonio/F-1661-2013
OI Guimaraes, Andre/0000-0002-3162-3206; Silva Barcelos,
   Luciola/0000-0001-9133-4011; Santos, Sergio/0000-0002-7788-5447; Wilke
   Saliba, Soraya/0000-0002-0983-9422; de Oliveira,
   Antonio/0000-0003-3217-4294; Freitas Lima, Leandro/0000-0001-9550-6095
FU Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
   [479254/2013-3]; Programa Primeiros Projetos (PPP) [CBB-APQ-04389-10];
   Programa Pesquisador Mineiro [PPM-00372-13]; Programa de Apoio a Nucleos
   Emergentes de Pesquisa [CBB-APQ-04625-10]; Pro-Reitoria de Pesquisa of
   the Universidade Federal de Minas Gerais (UFMG); CNPq fellowships;
   Fundacao de Amparo a Pesquisa do Estado de Minas Gerais (FAPEMIG)
FX Soraya Wilke Saliba received MSc. fellowship from Conselho Nacional de
   Desenvolvimento Cientifico e Tecnologico (CNPq). Antonio Carlos Pinheiro
   de Oliveira received research grants from Programa Primeiros Projetos
   (PPP - protocol number CBB-APQ-04389-10, Programa Pesquisador Mineiro -
   protocol number PPM-00372-13 and Programa de Apoio a Nucleos Emergentes
   de Pesquisa (protocol number CBB-APQ-04625-10), all from Fundacao de
   Amparo a Pesquisa do Estado de Minas Gerais (FAPEMIG); from CNPq
   (protocol number 479254/2013-3); and from Pro-Reitoria de Pesquisa of
   the Universidade Federal de Minas Gerais (UFMG). LSB, ACPdO, AMBdP, ALSG
   and SHSS are recipients of CNPq fellowships.
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NR 56
TC 17
Z9 17
U1 0
U2 9
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0893-7648
EI 1559-1182
J9 MOL NEUROBIOL
JI Mol. Neurobiol.
PD JUL
PY 2017
VL 54
IS 5
BP 3465
EP 3475
DI 10.1007/s12035-016-9927-x
PG 11
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA EV9IQ
UT WOS:000402100100032
PM 27181590
DA 2025-06-11
ER

PT J
AU Lau, C
   Yu, R
   Woo, J
AF Lau, Caren
   Yu, Ruby
   Woo, Jean
TI Effects of a 12-Week Hatha Yoga Intervention on Metabolic Risk and
   Quality of Life in Hong Kong Chinese Adults with and without Metabolic
   Syndrome
SO PLOS ONE
LA English
DT Article
ID CARDIOVASCULAR-DISEASE RISK; RANDOMIZED CONTROLLED-TRIAL;
   RESISTANCE-RELATED INDEXES; PHYSICAL-ACTIVITY; CHRONIC STRESS; HEALTH;
   EXERCISE; BENEFITS; HYPERTENSION; PREVALENCE
AB Objective
   To determine the efficacy of a 12-week Hatha yoga intervention to improve metabolic risk profiles and health-related quality of life (HRQoL) in Chinese adults with and without metabolic syndrome (MetS).
   Methods
   We conducted a controlled trial within an university-affiliated hospital. 173 Chinese men and women aged 18 or above were assigned to either the yoga intervention group (n = 87) or the control group (n = 86). Primary outcomes included 12-week change in metabolic risk factors and MetS z score. Secondary outcome was HRQoL (Medical Outcomes Short Form Survey at 12 weeks).
   Results
   The mean age of participants was 52.0 (SD 7.4, range 31-71) years. Analysis involving the entire study population revealed that the yoga group achieved greater decline in waist circumference (p<0.001), fasting glucose (p<0.01), triglycerides (p<0.05), and MetS z score (p<0.01). Yoga training also improved general health perceptions (p<0.01), physical component score (p<0.01), and social functioning (p<0.01) domains score of HRQoL. However, no significant differences between groups were observed in the mean change of systolic/diastolic blood pressures or high-density lipid protein cholesterol (all p>0.05). There were no significant differences in the intervention effects on waist circumference and MetS z score between the MetS subgroups (both p>0.05).
   Conclusion
   A 12-week Hatha yoga intervention improves metabolic risk profiles and HRQoL in Chinese adults with and without MetS.
C1 [Lau, Caren; Yu, Ruby; Woo, Jean] Chinese Univ Hong Kong, Dept Med & Therapeut, Hong Kong, Hong Kong, Peoples R China.
C3 Chinese University of Hong Kong
RP Yu, R (corresponding author), Chinese Univ Hong Kong, Dept Med & Therapeut, Hong Kong, Hong Kong, Peoples R China.
EM rubyyu@cuhk.edu.hk
RI Yu, Ruby/N-5006-2015; Woo, Jean/K-2625-2014
OI Woo, Jean/0000-0001-7593-3081
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NR 44
TC 28
Z9 37
U1 1
U2 12
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JUN 25
PY 2015
VL 10
IS 6
AR e0130731
DI 10.1371/journal.pone.0130731
PG 18
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Science & Technology - Other Topics
GA CL4OY
UT WOS:000356933800079
PM 26111165
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Sciarretta, S
   Zhai, PY
   Shao, D
   Maejima, Y
   Robbins, J
   Volpe, M
   Condorelli, G
   Sadoshima, J
AF Sciarretta, Sebastiano
   Zhai, Peiyong
   Shao, Dan
   Maejima, Yasuhiro
   Robbins, Jeffrey
   Volpe, Massimo
   Condorelli, Gianluigi
   Sadoshima, Junichi
TI Rheb is a Critical Regulator of Autophagy During Myocardial Ischemia
   Pathophysiological Implications in Obesity and Metabolic Syndrome
SO CIRCULATION
LA English
DT Article
DE apoptosis; ischemia; obesity; signal transduction
ID INSULIN-RESISTANCE; SKELETAL-MUSCLE; MAMMALIAN TARGET; HEART-FAILURE;
   MTOR; INFARCTION; ACTIVATION; RAPAMYCIN; PATHWAY; IMPACT
AB Background-Rheb is a GTP-binding protein that promotes cell survival and mediates the cellular response to energy deprivation (ED). The role of Rheb in the regulation of cell survival during ED has not been investigated in the heart.
   Methods and Results-Rheb is inactivated during cardiomyocyte (CM) glucose deprivation (GD) in vitro, and during acute myocardial ischemia in vivo. Rheb inhibition causes mTORC1 inhibition, because forced activation of Rheb, through Rheb overexpression in vitro and through inducible cardiac-specific Rheb overexpression in vivo, restored mTORC1 activity. Restoration of mTORC1 activity reduced CM survival during GD and increased infarct size after ischemia, both of which were accompanied by inhibition of autophagy, whereas Rheb knockdown increased autophagy and CM survival. Rheb inhibits autophagy mostly through Atg7 depletion. Restoration of autophagy, through Atg7 reexpression and inhibition of mTORC1, increased cellular ATP content and reduced endoplasmic reticulum stress, thereby reducing CM death induced by Rheb activation. Mice with high-fat diet-induced obesity and metabolic syndrome (HFD mice) exhibited deregulated cardiac activation of Rheb and mTORC1, particularly during ischemia. HFD mice presented inhibition of cardiac autophagy and displayed increased ischemic injury. Pharmacological and genetic inhibition of mTORC1 restored autophagy and abrogated the increase in infarct size observed in HFD mice, but they failed to protect HFD mice in the presence of genetic disruption of autophagy.
   Conclusions-Inactivation of Rheb protects CMs during ED through activation of autophagy. Rheb and mTORC1 may represent therapeutic targets to reduce myocardial damage during ischemia, particularly in obese patients. (Circulation. 2012;125:1134-1146.)
C1 [Sciarretta, Sebastiano; Zhai, Peiyong; Shao, Dan; Maejima, Yasuhiro; Sadoshima, Junichi] Univ Med & Dent New Jersey, New Jersey Med Sch, Cardiovasc Res Inst, Dept Cell Biol, Newark, NJ 07103 USA.
   [Sciarretta, Sebastiano; Zhai, Peiyong; Shao, Dan; Maejima, Yasuhiro; Sadoshima, Junichi] Univ Med & Dent New Jersey, New Jersey Med Sch, Cardiovasc Res Inst, Dept Mol Med, Newark, NJ 07103 USA.
   [Sciarretta, Sebastiano; Volpe, Massimo] IRCCS Neuromed, Pozzilli, IS, Italy.
   [Robbins, Jeffrey] Cincinnati Childrens Hosp, Inst Heart, Cincinnati, OH USA.
   [Volpe, Massimo] Univ Roma La Sapienza, Dept Cardiol, Sch Med 2, S Andrea Hosp, Rome, Italy.
   [Condorelli, Gianluigi] Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA.
C3 Rutgers University System; Rutgers University New Brunswick; Rutgers
   University Biomedical & Health Sciences; Rutgers University System;
   Rutgers University New Brunswick; Rutgers University Biomedical & Health
   Sciences; IRCCS Neuromed; Cincinnati Children's Hospital Medical Center;
   Sapienza University Rome; Azienda Ospedaliera Sant'Andrea; University of
   California System; University of California San Diego
RP Sadoshima, J (corresponding author), Univ Med & Dent New Jersey, New Jersey Med Sch, Cardiovasc Res Inst, Dept Cell Biol, 185 S Orange Ave,Med Sci Bldg G-609, Newark, NJ 07103 USA.
EM Sadoshju@umdnj.edu
RI Maejima, Yasuhiro/AAG-5580-2020; Volpe, Massimo/K-5240-2016; Sciarretta,
   Sebastiano/K-5161-2016; Condorelli, Gianluigi/Q-6736-2017
OI Maejima, Yasuhiro/0000-0001-7450-4840; Sadoshima,
   Junichi/0000-0003-3724-4132; Sciarretta, Sebastiano/0000-0002-8633-6896;
   Condorelli, Gianluigi/0000-0003-0481-6843; Volpe,
   Massimo/0000-0002-9642-8380
FU American Heart Association [10POST4260019]; US Public Health Service
   [HL59139, HL67724, HL69020, HL91469, HL102738, AG27211]; Foundation of
   Leducq Trans-atlantic Network of Excellence; American Heart Association
   (AHA) [10POST4260019] Funding Source: American Heart Association (AHA)
FX Dr Sciarretta is supported by the American Heart Association Founders
   Affiliate FDA Spring 2010 postdoctoral fellowship 10POST4260019. This
   work was supported in part by US Public Health Service grants HL59139,
   HL67724, HL69020, HL91469, HL102738, and AG27211 and by the Foundation
   of Leducq Trans-atlantic Network of Excellence.
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NR 35
TC 259
Z9 278
U1 0
U2 25
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0009-7322
J9 CIRCULATION
JI Circulation
PD MAR 6
PY 2012
VL 125
IS 9
BP 1134
EP U166
DI 10.1161/CIRCULATIONAHA.111.078212
PG 25
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 904LK
UT WOS:000301197700020
PM 22294621
OA Bronze, Green Accepted, Green Published
DA 2025-06-11
ER

PT J
AU Sookoian, S
   Pirola, CJ
AF Sookoian, Silvia
   Pirola, Carlos J.
TI Metabolic Syndrome: From the Genetics to the Pathophysiology
SO CURRENT HYPERTENSION REPORTS
LA English
DT Article
DE Cardiometabolic syndrome; Insulin resistance; Obesity; Hypertension;
   Diabetes; Arterial blood pressure; Glucose; Insulin; Triglycerides;
   Cholesterol; Dyslipidemia; Genetics; Gene; Variants; Epigenetics; DNA
   methylation; Systems biology; miRNAs; SLC7A1; CLOCK; SLC6A4; Epistasis;
   Small for gestational age; Newborns; Adolescents
ID CLOCK TRANSCRIPTION FACTOR; GENOME-WIDE ASSOCIATION; EPISTATIC
   INTERACTION; INSULIN-RESISTANCE; POLYMORPHISM; CHOLESTEROL; PROMOTER;
   RECEPTOR; OBESITY; RISK
AB The metabolic syndrome (MS) constitutes a combination of underlying risk factors for an adverse outcome, cardiovascular disease. Thus, the clinical behavior of the MS can be regarded as a whole. Nevertheless, from a pathogenic point of view, understanding of the underlying mechanisms of each MS intermediate phenotype is far beyond their understanding as an integrative process. Systems biology introduces a new concept for revealing the pathogenesis of human disorders and suggests the presence of common physiologic processes and molecular networks influencing the risk of a disease. This paper shows a model of this concept to explain the genetic determinants of MS-associated phenotypes. Based on the hypothesis that common physiologic processes and molecular networks may influence the risk of MS disease components, we propose two systems-biology approaches: a gene enrichment analysis and the use of a protein-protein interaction network. Our results show that a network driven by many members of the nuclear receptor superfamily of proteins, including retinoid X receptor and farnesoid X receptor (FXR), may be implicated in the pathogenesis of the MS by its interactions at multiple levels of complexity with genes associated with metabolism, cell differentiation, and oxidative stress. In addition, we review two alternative genetic mechanisms that are gaining acceptance in the physiopathology of the MS: the regulation of transcriptional and post-transcriptional gene expression by microRNAs and epigenetic modifications such as DNA methylation.
C1 [Pirola, Carlos J.] Univ Buenos Aires, Dept Mol Genet & Biol Complex Dis, Inst Med Res A Lanari IDIM, Natl Council Sci & Technol Res CONICET, Buenos Aires, DF, Argentina.
   [Sookoian, Silvia] Univ Buenos Aires, Dept Clin & Mol Hepatol, Inst Med Res A Lanari IDIM, Natl Council Sci & Technol Res CONICET, Buenos Aires, DF, Argentina.
C3 Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET);
   University of Buenos Aires; University of Buenos Aires; Consejo Nacional
   de Investigaciones Cientificas y Tecnicas (CONICET)
RP Pirola, CJ (corresponding author), Univ Buenos Aires, Dept Mol Genet & Biol Complex Dis, Inst Med Res A Lanari IDIM, Natl Council Sci & Technol Res CONICET, Av Combatiente Malvinas 3150,C1427ARO, Buenos Aires, DF, Argentina.
EM ssookoian@lanari.fmed.uba.ar; pirola.carlos@lanari.fmed.uba.ar
RI Pirola, Carlos/H-2720-2019
OI Pirola, Carlos Jose/0000-0001-8234-4058
FU Universidad de Buenos Aires [UBACYT M055]; Agencia Nacional de Promocion
   Cientifica y Tecnologica [PICT 2006-124]
FX Supported in part by Grants UBACYT M055 (Universidad de Buenos Aires)
   and PICT 2006-124 (Agencia Nacional de Promocion Cientifica y
   Tecnologica). SS and CJP are members of Consejo Nacional de
   Investigaciones Cientificas (CONICET).
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NR 37
TC 66
Z9 69
U1 0
U2 26
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1522-6417
EI 1534-3111
J9 CURR HYPERTENS REP
JI Curr. Hypertens. Rep.
PD APR
PY 2011
VL 13
IS 2
BP 149
EP 157
DI 10.1007/s11906-010-0164-9
PG 9
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 729CM
UT WOS:000287925700010
PM 20957457
DA 2025-06-11
ER

PT J
AU Toblli, JE
   Cao, G
   Giani, JF
   Angerosa, M
   Dominici, FP
   Gonzalez-Cadavid, NF
AF Toblli, Jorge E.
   Cao, Gabriel
   Giani, Jorge F.
   Angerosa, Margarita
   Dominici, Fernando P.
   Gonzalez-Cadavid, Nestor F.
TI Antifibrotic Effects of Pioglitazone at Low Doses on the Diabetic Rat
   Kidney Are Associated with the Improvement of Markers of Cell Turnover,
   Tubular and Endothelial Integrity, and Angiogenesis
SO KIDNEY & BLOOD PRESSURE RESEARCH
LA English
DT Article
DE Diabetic nephropathy; Thiazolidinediones; Peroxisome
   proliferator-activated receptor-gamma; Metabolic syndrome; Fibrosis;
   Inflammation; ZDF fa/fa rat; Nitric oxide synthase; VEGF; Megalin
ID ACTIVATED-RECEPTOR-GAMMA; TISSUE GROWTH-FACTOR; VENOOCCLUSIVE
   DYSFUNCTION; INSULIN-RESISTANCE; METABOLIC SYNDROME; NEPHROPATHY;
   THIAZOLIDINEDIONES; ROSIGLITAZONE; DISEASE; GLOMERULOSCLEROSIS
AB Background/Aims: Pioglitazone and other thiazolidinediones are renoprotective in diabetic nephropathy at doses that normalize glycemia, presumably as a consequence of glycennic control. However, low doses of pioglitazone that did not normalize glycemia in rat models of type 2 diabetes prevented tubulointerstitial fibrosis and glomerulosclerosis through counteracting inflammation, oxidative stress, cell cycle arrest, and fibrosis. The current work tested whether this low-dose treatment also reduces other fibrosis and inflammation factors in the diabetic kidney and prevents tubular cell loss, endothelial damage, and abnormal angiogenesis. Methods: ZDF fa/fa rats (ZDF) were fed for 4 months chow with 0.001% pioglitazone, and the untreated ZDF and the non-diabetic lean Zucker rats (LZR) received regular chow. Proteinuria, creatinine clearance, blood pressure, and renal quantitative histopathology markers were determined. Results: Correction of renal function in ZDF by pioglitazone, occurring with a glycemia >250 mg/dl, was accompanied by normalization of the renal levels of connective tissue growth factor and fibronectin (fibrosis), TNF-alpha, interleukin-6 and MCP-1 (inflammation), megalin (tubular cells), the PCNA/caspase-3 ratio (positive cell turnover), VEGF (abnormal angiogenesis), and the ratio between eNOS and iNOS (endothelial dysfunction). Conclusion:This supports mechanisms for the renoprotective effects of pioglitazone in diabetes additional to glycemic control. Copyright (C) 2010 S. Karger AG, Basel
C1 [Gonzalez-Cadavid, Nestor F.] Harbor UCLA Med Ctr, LABioMed, Urol Res Lab, Los Angeles Biomed Res Inst, Torrance, CA 90502 USA.
   [Toblli, Jorge E.; Cao, Gabriel; Angerosa, Margarita] Hosp Aleman, Expt Med Lab, Buenos Aires, DF, Argentina.
   [Giani, Jorge F.; Dominici, Fernando P.] UBA CONICET, Inst Quim & Fis Quim Biol, Buenos Aires, DF, Argentina.
   [Gonzalez-Cadavid, Nestor F.] Univ Calif Los Angeles, David Geffen Sch Med, Dept Urol, Los Angeles, CA 90095 USA.
   [Gonzalez-Cadavid, Nestor F.] Charles Drew Univ, Dept Internal Med, Los Angeles, CA USA.
C3 University of California System; University of California Los Angeles;
   University of California Los Angeles Medical Center; Lundquist
   Institute; Hospital Aleman; University of Buenos Aires; University of
   Buenos Aires Hospital; Consejo Nacional de Investigaciones Cientificas y
   Tecnicas (CONICET); University of Buenos Aires; CONICET UBA; University
   of California System; University of California Los Angeles; University
   of California Los Angeles Medical Center; David Geffen School of
   Medicine at UCLA; Charles R. Drew University of Medicine & Science
RP Gonzalez-Cadavid, NF (corresponding author), Harbor UCLA Med Ctr, LABioMed, Urol Res Lab, Los Angeles Biomed Res Inst, Bldg F-6,1124 W Carson St, Torrance, CA 90502 USA.
EM ncadavid@ucla.edu
RI Cao, Gabriel/LJL-8755-2024
OI Dominici, Fernando Pablo/0000-0002-4351-0057; Giani,
   Jorge/0000-0003-0481-6595
FU Takeda Pharmaceuticals North America, Inc.; American Diabetes
   Association (ADA) [7-05-RA-44 ADA]; NIH [NIHR01 DK53069]; University of
   Buenos Aires (UBA); CONICET; Agencia Nacional de Promocion Cientifica y
   Tecnologica of Argentina
FX This work was supported by an investigator-initiated grant from Takeda
   Pharmaceuticals North America, Inc., and grants from the American
   Diabetes Association (#7-05-RA-44 ADA), and NIH (NIHR01 DK53069), to
   N.G.C.J.E.T. and F.P.D. are career investigators from the Consejo
   Nacional de Investigaciones Cientificas y Tecnologicas of Argentina
   (CONICET) and received grant support from the University of Buenos Aires
   (UBA), CONICET and Agencia Nacional de Promocion Cientifica y
   Tecnologica of Argentina. J.F.G. is a research fellow from CONICET.
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NR 50
TC 28
Z9 33
U1 0
U2 2
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1420-4096
EI 1423-0143
J9 KIDNEY BLOOD PRESS R
JI Kidney Blood Pressure Res.
PY 2011
VL 34
IS 1
BP 20
EP 33
DI 10.1159/000320380
PG 14
WC Physiology; Urology & Nephrology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology; Urology & Nephrology; Cardiovascular System & Cardiology
GA 710VQ
UT WOS:000286545500003
PM 21071958
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Montagut, G
   Bladé, C
   Blay, M
   Fernández-Larrea, J
   Pujadas, G
   Salvadó, MJ
   Arola, L
   Pinent, M
   Ardévol, A
AF Montagut, Gemma
   Blade, Cinta
   Blay, Mayte
   Fernandez-Larrea, Juan
   Pujadas, Gerard
   Josepa Salvado, M.
   Arola, Lluis
   Pinent, Montserrat
   Ardevol, Anna
TI Effects of a grapeseed procyanidin extract (GSPE) on insulin resistance
SO JOURNAL OF NUTRITIONAL BIOCHEMISTRY
LA English
DT Article
DE High-fat diet; Adipose tissue; Obesity; Procyanidins; Insulin resistance
ID INDUCED DIABETIC-RATS; GREEN TEA POLYPHENOL; 3T3-L1 ADIPOCYTES;
   METABOLIC-SYNDROME; OXIDATIVE STRESS; GLUCOSE-UPTAKE; BLOOD-PRESSURE;
   EXPRESSION; MICE; PROANTHOCYANIDIN
AB Flavonoids are beneficial compounds against risk factors for metabolic syndrome, but their effects and the mechanisms on glucose homeostasis modulation are not well defined. In the present study, we first checked the efficacy of grapeseed procyanidin extract (GSPE) for stimulating glucose uptake in insulin-resistant 3T3-L1 adipocytes. Results show that when resistance is induced with chronic insulin treatment, GSPE maintain a higher stimulating capacity than insulin. In contrast, when dexamethasone is used as the resistance-inducing agent, GSPE is less effective. Next we evaluated how effective different GSPE treatments are at improving glucose metabolism in hyperinsulinemic animals (fed a cafeteria diet). GSPE reduced plasma insulin levels. The lower dose (25 mg GSPE/kg body weight per day) administered for 30 days improved the HOmeostasis Model Assessment-insulin resistance index. This was accompanied by down-regulation of Pparg2, Glut4 and Irs1 in mesenteric white adipose tissue. Similarly, a chronic GSPE treatment of insulin-resistant 3T3-L1 adipocytes down-regulated the mRNA levels of those adipocyte markers, although cells were still able to respond to the acute stimulation of glucose uptake.
   In summary, 25 mg/kg body weight per day of GSPE has a positive long-term effect on glucose homeostasis, and GSPE could be targeted at adipose tissue, where it might directly stimulate glucose uptake. This work also highlights the need to carefully consider the bioactive dose, since a higher dose does not necessarily correlate to a greater positive effect. (C) 2010 Elsevier Inc. All rights reserved.
C1 [Montagut, Gemma; Blade, Cinta; Blay, Mayte; Fernandez-Larrea, Juan; Pujadas, Gerard; Josepa Salvado, M.; Arola, Lluis; Pinent, Montserrat; Ardevol, Anna] Univ Rovira & Virgili, Dept Biochem & Biotechnol, Tarragona 43007, Spain.
C3 Universitat Rovira i Virgili
RP Ardévol, A (corresponding author), Univ Rovira & Virgili, Dept Biochem & Biotechnol, C Marcel li Domingo S-N, Tarragona 43007, Spain.
EM anna.ardevol@urv.cat
RI Ardévol, Anna/AAO-6194-2021; PUJADAS, GERARD/W-9348-2019; SALVADO,
   JOSEPA/B-6062-2015; Arola, Lluis/C-6074-2011; Blay, M.
   Teresa/B-1680-2009; Pujadas, Gerard/B-1457-2010; Pinent,
   Montserrat/C-7109-2011
OI Blade, Cinta/0000-0003-2838-2402; Fernandez-Larrea, Juan
   Bautista/0000-0001-8007-8040; SALVADO, JOSEPA/0000-0003-3883-3326;
   Montagut Pino, Gemma/0000-0001-8954-0449; Arola,
   Lluis/0000-0003-2767-1974; Blay, M. Teresa/0000-0002-6256-9847; Pujadas,
   Gerard/0000-0003-2598-8089; Pinent, Montserrat/0000-0003-3550-5378;
   Ardevol, Anna/0000-0003-0156-7538
FU Ministerio de Ciencia e Innovacion (MICINN) of the Spanish Government
   [AGL2008-01310/ALI, AGL2008-00387/ALI]; Rovira i Virgili University in
   Tarragona
FX This study was supported by grant numbers AGL2008-01310/ALI,
   AGL2008-00387/ALI from the Ministerio de Ciencia e Innovacion (MICINN)
   of the Spanish Government. Gemma Montagut is a recipient of a fellowship
   from the Rovira i Virgili University in Tarragona.
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NR 38
TC 94
Z9 105
U1 0
U2 56
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0955-2863
EI 1873-4847
J9 J NUTR BIOCHEM
JI J. Nutr. Biochem.
PD OCT
PY 2010
VL 21
IS 10
BP 961
EP 967
DI 10.1016/j.jnutbio.2009.08.001
PG 7
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA 656RQ
UT WOS:000282354700010
PM 19962298
DA 2025-06-11
ER

PT S
AU Kanaka-Gantenbein, C
   Mastorakos, G
   Chrousos, GP
AF Kanaka-Gantenbein, C
   Mastorakos, G
   Chrousos, GP
BE Creatsas, G
   Mastorakos, G
   Chrousos, GP
TI Endocrine-related causes and consequences of intrauterine growth
   retardation
SO WOMEN'S HEALTH AND DISEASE: GYNECOLOGIC AND REPRODUCTIVE ISSUES
SE Annals of the New York Academy of Sciences
LA English
DT Article; Proceedings Paper
CT 5th Athens Congress on Womens Health and Disease
CY SEP 26-29, 2002
CL ATHENS, GREECE
SP Univ Athens, Med Sch, Second Dept Obstet & Gynecol, Int Federat Obstet & Gynecol, Hellen Soc Obstet, Hellen Soc Pediat & Adolescent Gynecol
DE IUGR; SGA; fetal origin; adult disease; metabolic syndrome; insulin
   resistance; diabetes mellitus type 2; cardiovascular disease; premature
   adrenarche; polycystic ovary syndrome
ID LOW-BIRTH-WEIGHT; FOR-GESTATIONAL-AGE; REDUCED FETAL GROWTH; IMPAIRED
   GLUCOSE-TOLERANCE; ISCHEMIC-HEART-DISEASE; ADULT DISEASE;
   INSULIN-RESISTANCE; PRECOCIOUS PUBARCHE; PRENATAL EXPOSURE;
   BLOOD-PRESSURE
AB The term intrauterine growth retardation (IUGR) is assigned to newborns born with a birth weight and/or birth length below the tenth percentile for their gestational age. Intrauterine growth retardation is usually due to maternal, fetal factors, or placental insufficiency, while endocrine factors represent just a small minority in its etiology. Main endocrine-related causes of IUGR are disorders in insulin or insulin-like growth factor-I (IGF-I) secretion or action. Newborns with IUGR are at increased risk to develop a metabolic syndrome later in life, namely obesity, arterial hypertension, hypercholesterolemia, cardiovascular disease, impaired glucose tolerance, or diabetes mellitus type 2. This association is the result of the adaptational changes of the fetal endocrine-metabolic mechanisms to the impaired intrauterine milieu to assure survival in the short term. The persistence of these changes after birth can be detrimental in adult life. Furthermore, premature adrenarche, as well as ovarian hyperandrogenism, seem to be associated with IUGR in girls, demonstrating that IUGR may have long-lasting effects on both somatic health and reproductive function. Finally, the intrauterine exposure of the fetus to stressors may affect the individual's ability to face stress in postnatal life. Therefore, if optimization of somatic and psychosocial well-being of the individual is the golden goal of medicine, special attention should be paid to maintain an optimal intrauterine milieu devoid of any stressors With adequate nutrient supply and to reserve ideal psychosocial support to the pregnant woman.
C1 Univ Athens, Agia Sofia Childrens Hosp, Sch Med, Dept Pediat Endocrinol,Dept Pediat 1, Athens, Greece.
   Univ Athens, Aretaie Hosp, Sch Med, Dept Obstet & Gynecol 2, Athens, Greece.
   NICHHD, Pediat & Reprod Endocrinol Branch, NIH, Bethesda, MD 20892 USA.
C3 The Aghia Sophia Children's Hospital; Athens Medical School; National &
   Kapodistrian University of Athens; National & Kapodistrian University of
   Athens; Athens Medical School; National Institutes of Health (NIH) -
   USA; NIH Eunice Kennedy Shriver National Institute of Child Health &
   Human Development (NICHD)
RP Tymfristou 52, Athens 15234, Greece.
EM ganten@hol.gr
RI Kanaka-Gantenbein, Christina/AAP-3697-2020
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NR 55
TC 72
Z9 84
U1 0
U2 8
PU NEW YORK ACAD SCIENCES
PI NEW YORK
PA 2 EAST 63RD ST, NEW YORK, NY 10021 USA
SN 0077-8923
BN 1-57331-458-7
J9 ANN NY ACAD SCI
JI Ann.NY Acad.Sci.
PY 2003
VL 997
BP 150
EP 157
DI 10.1196/annals.1290.017
PG 8
WC Multidisciplinary Sciences; Obstetrics & Gynecology
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics; Obstetrics & Gynecology
GA BY06G
UT WOS:000187495800018
PM 14644821
DA 2025-06-11
ER

PT J
AU Jiang, HF
   Lin, Q
   Ma, LN
   Luo, SD
   Jiang, XM
   Fang, J
   Lu, ZM
AF Jiang, Hongfei
   Lin, Qian
   Ma, Leina
   Luo, Shudi
   Jiang, Xiaoming
   Fang, Jing
   Lu, Zhimin
TI Fructose and fructose kinase in cancer and other pathologies
SO JOURNAL OF GENETICS AND GENOMICS
LA English
DT Review
DE Fructose; Glucose; KHKeC; KHK-A; Cancer; NAFLD; NASH; Metabolic
   disorders
ID FATTY LIVER-DISEASE; METABOLIC SYNDROME; DIETARY FRUCTOSE;
   PROTEIN-KINASE; RISK-FACTORS; FOOD-INTAKE; KETOHEXOKINASE; STRESS;
   PATHOGENESIS; AUTOPHAGY
AB Fructose metabolism and fructose kinase KHKeC/A are key factors in the development of lipid oversynthesis-promoted metabolic disorders and cancer. Here, we summarize and discuss the current knowledge about the specific features of fructose metabolism and the distinct roles of KHKeC and KHKeA in metabolic liver diseases and their relevant metabolic disorders and cancer, and we highlight the specific protein kinase activity of KHKeA in tumor development. In addition, different approaches that have been used to inhibit KHK and the exploration of KHK inhibitors in clinical treatment are introduced. Copyright (C) 2021, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, and Genetics Society of China. Published by Elsevier Limited and Science Press. All rights reserved.
C1 [Jiang, Hongfei; Lin, Qian; Ma, Leina; Fang, Jing] Qingdao Univ, Canc Inst, Affiliated Hosp, Qingdao 266061, Peoples R China.
   [Jiang, Hongfei; Lin, Qian; Ma, Leina; Fang, Jing] Qingdao Canc Inst, Qingdao 266061, Peoples R China.
   [Lu, Zhimin] Zhejiang Univ, Affiliated Hosp 1, Inst Translat Med, Zhejiang Prov Key Lab Pancreat Dis,Sch Med, Hangzhou 310029, Peoples R China.
   [Luo, Shudi; Jiang, Xiaoming; Lu, Zhimin] Zhejiang Univ, Canc Ctr, Hangzhou 310029, Peoples R China.
C3 Qingdao University; Zhejiang University; Zhejiang University
RP Fang, J (corresponding author), Qingdao Univ, Canc Inst, Affiliated Hosp, Qingdao 266061, Peoples R China.; Fang, J (corresponding author), Qingdao Canc Inst, Qingdao 266061, Peoples R China.; Lu, ZM (corresponding author), Zhejiang Univ, Affiliated Hosp 1, Inst Translat Med, Zhejiang Prov Key Lab Pancreat Dis,Sch Med, Hangzhou 310029, Peoples R China.; Lu, ZM (corresponding author), Zhejiang Univ, Canc Ctr, Hangzhou 310029, Peoples R China.
EM jfang@qdu.edu.cn; zhiminlu@zju.edu.cn
RI Lu, Zhimin/LZF-0860-2025
FU Ministry of Science and Technology of the People's Republic of China
   [2020YFA0803300]; National Natural Science Foundation of China
   [82030074, 82073061, 81672926]; Zhejiang Natural Science Foundation-Key
   Project [LD21H160003]; Zhejiang University Research Fund
   [188020*194221901/029]; Leading Innovative and Entrepreneur Team
   Introduction Program of Zhejiang [2019R01001]
FX This study was supported by grants from the Ministry of Science and
   Technology of the People's Republic of China (2020YFA0803300 to Z.L.,
   J.F.), the National Natural Science Foundation of China (82030074, Z.L.;
   82073061, J.F.; 81672926, L.M.), the Zhejiang Natural Science
   Foundation-Key Project (LD21H160003, Z.L.), the Zhejiang University
   Research Fund (188020*194221901/029, Z.L.), and the Leading Innovative
   and Entrepreneur Team Introduction Program of Zhejiang (2019R01001,
   Z.L.). Z.L. is the Kuancheng Wang Distinguished Chair.
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NR 91
TC 19
Z9 19
U1 7
U2 40
PU SCIENCE PRESS
PI BEIJING
PA 16 DONGHUANGCHENGGEN NORTH ST, BEIJING 100717, PEOPLES R CHINA
SN 1673-8527
EI 1873-5533
J9 J GENET GENOMICS
JI J. Genet. Genomics
PD JUL 20
PY 2021
VL 48
IS 7
BP 531
EP 539
DI 10.1016/j.jgg.2021.06.006
PG 9
WC Biochemistry & Molecular Biology; Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Genetics & Heredity
GA US4BC
UT WOS:000697375800003
PM 34326012
DA 2025-06-11
ER

PT J
AU Lim, S
   Kim, JW
   Targher, G
AF Lim, Soo
   Kim, Jin-Wook
   Targher, Giovanni
TI Links between metabolic syndrome and metabolic dysfunction-associated
   fatty liver disease
SO TRENDS IN ENDOCRINOLOGY AND METABOLISM
LA English
DT Review
ID TYPE-2 DIABETES-MELLITUS; INDEPENDENT RISK-FACTOR; TERM-FOLLOW-UP;
   INSULIN-RESISTANCE; CARDIOVASCULAR-DISEASE; ENDOPLASMIC-RETICULUM;
   HEPATIC STEATOSIS; SKELETAL-MUSCLE; FIBROSIS STAGE; NAFLD
AB Metabolic dysfunction-associated fatty liver disease (MAFLD) is a chronic condition characterized by hepatic fat accumulation combined with underlying metabolic dysregulation. Having evolved from the previous term of nonalcoholic fatty liver disease (NAFLD), the term MAFLD more closely implicates the presence of overweight/obesity, type 2 diabetes, or metabolic dysregulation as essential pathogenic factors, leading to better identification of individuals with this metabolic liver disease. Low-grade inflammation, increased oxidative stress, mitochondrial dysfunction, and intestinal dysbiosis are also involved in its pathogenesis. MAFLD is not only associated with liver-related complications, but also with adverse cardiometabolic outcomes. Further studies are needed to assess whether the newly proposed definition of MAFLD is more accurate than the NAFLD in predicting the adverse liver-related and extrahepatic outcomes.
C1 [Lim, Soo; Kim, Jin-Wook] Seoul Natl Univ, Coll Med, Dept Internal Med, Bundang Hosp, Seoul, South Korea.
   [Targher, Giovanni] Univ Verona, Dept Med, Sect Endocrinol Diabet & Metab, Verona, Italy.
C3 Seoul National University (SNU); Seoul National University Hospital;
   University of Verona
RP Lim, S (corresponding author), Seoul Natl Univ, Coll Med, Dept Internal Med, Bundang Hosp, Seoul, South Korea.; Targher, G (corresponding author), Univ Verona, Dept Med, Sect Endocrinol Diabet & Metab, Verona, Italy.
EM limsoo@snu.ac.kr; giovanni.targher@univr.it
RI Kim, Jin-Wook/J-5442-2012; Lim, Soo/AAU-8107-2020; Targher,
   Giovanni/AAB-9008-2019
OI Targher, Giovanni/0000-0002-4325-3900
FU Sharp Dohme; AstraZeneca; Merck; Astellas
FX S.L. has been a member of advisory boards or has consulted with Merck,
   Sharp & Dohme and NovoNordisk. S.L. has received grant support from
   AstraZeneca, Merck, Sharp & Dohme, and Astellas. S.L. has also served on
   the speakers' bureau of AstraZeneca, Boehringer Ingelheim, Eli Lilly &
   Co., Merck, Sharp & Dohme, CKD Pharmaceutical, and NovoNordisk. J.W.K.
   and G.T. have nothing to disclaim. All authors have no other conflicts
   of interest to declare for this article.
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NR 137
TC 122
Z9 127
U1 5
U2 61
PU CELL PRESS
PI CAMBRIDGE
PA 50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA
SN 1043-2760
EI 1879-3061
J9 TRENDS ENDOCRIN MET
JI Trends Endocrinol. Metab.
PD JUL
PY 2021
VL 32
IS 7
BP 500
EP 514
DI 10.1016/j.tem.2021.04.008
EA JUN 2021
PG 15
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA SP2HK
UT WOS:000659494900010
PM 33975804
DA 2025-06-11
ER

PT J
AU Fan, ZJ
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AF Fan, Zhijia
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   Lin, Yong
   Wang, Zhicheng
TI Platelet Dysfunction and Its Role in the Pathogenesis of Psoriasis
SO DERMATOLOGY
LA English
DT Review
DE Psoriasis; Platelets; Thrombosis; Inflammation
ID NEUTROPHIL-LYMPHOCYTE RATIO; METABOLIC SYNDROME; OXIDATIVE STRESS;
   CARDIOVASCULAR RISK; DISTRIBUTION WIDTH; DISEASE-ACTIVITY; IMMUNE CELLS;
   P-SELECTIN; ACTIVATION; MICROPARTICLES
AB Background: Psoriasis is an immune-mediated inflammatory skin disease in conjunction with the systemic inflammatory process. It appears to be related to increased risks of cardiovascular disease events, especially in severe cases. The hemostatic balance is disrupted due to the prothrombotic bias in psoriasis, which might be mainly preserved by platelet hyperactivity. Platelets are also immune cells that initiate and regulate immune and inflammatory processes, except as the principal mediator of hemostasis and thrombosis, and platelet dysfunction is deeply involved in the pathogenesis of psoriasis. Summary: The aim of this study is to perform a review that expounds abnormal platelet function in psoriasis and explains the important role of platelets in the pathogenic mechanism of psoriasis in order to provide new targets for comprehensive medical treatment.
C1 [Fan, Zhijia; Wang, Li; Jiang, Haoqin; Lin, Yong; Wang, Zhicheng] Fudan Univ, Shanghai Med Coll, Huashan Hosp, Dept Lab Med, 12 Wulumuqi Middle Rd, Shanghai 200040, Peoples R China.
C3 Fudan University
RP Lin, Y; Wang, ZC (corresponding author), Fudan Univ, Shanghai Med Coll, Huashan Hosp, Dept Lab Med, 12 Wulumuqi Middle Rd, Shanghai 200040, Peoples R China.
EM linyong7007@163.com; ahwzc@126.com
RI Jiang, Haoqin/KOD-7657-2024; Fan, Zhijia/MEO-0053-2025; Wang,
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OI Lin, Yong/0000-0001-5921-3404; Jiang, Haoqin/0000-0003-1134-1583
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NR 100
TC 23
Z9 23
U1 0
U2 7
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1018-8665
EI 1421-9832
J9 DERMATOLOGY
JI Dermatology
PD JAN
PY 2021
VL 237
IS 1
BP 56
EP 65
DI 10.1159/000505536
PG 10
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA PU7ED
UT WOS:000609462100009
PM 32349003
OA Bronze
DA 2025-06-11
ER

PT J
AU Chatterjee, S
   Ghosh, R
   Biswas, P
   Dubey, S
   Guria, RT
   Sharma, CB
   Kalra, S
AF Chatterjee, Subhankar
   Ghosh, Ritwik
   Biswas, Payel
   Dubey, Souvik
   Guria, Rishi T.
   Sharma, Chandra B.
   Kalra, Sanjay
TI COVID-19: the endocrine opportunity in a pandemic
SO MINERVA ENDOCRINOLOGICA
LA English
DT Review
DE COVID-19; Endocrinology; Hormones; Diabetes; Obesity; Mortality
ID ANGIOTENSIN-CONVERTING ENZYME; CORONAVIRUS DISEASE 2019; CORTICOSTEROID
   TREATMENT; DIABETES-MELLITUS; SEX-HORMONES; SARS; OUTCOMES; VIRUS;
   INFLAMMATION; PREVALENCE
AB The 2019 Coronavirus disease (COVID-19) pandemic has disrupted the social, economical and medical system worldwide. Although it is strictly an infectious disease, its intricate bidirectional relationship with various non-communicable metabolic diseases and endocrinological factors has been observed. While diabetes, hypertension, obesity have been found to be independent risk factors for COVID-19 disease severity and mortality, more inclination towards sedentary lifestyle, psychosocial stress at this critical time may be the harbingers of metabolic syndrome. Thus, endocrinologists have a great opportunity to play their role to combat this pandemic. This paper examines how various endocrinological disorders influence the dynamics of COVID-19 and vice versa. Moreover, it also intends to review the clinical guidelines to be adopted in practice of endocrinology in this trying time.
C1 [Chatterjee, Subhankar; Guria, Rishi T.; Sharma, Chandra B.] Rajendra Inst Med Sci, Dept Gen Med, Ranchi, Bihar, India.
   [Ghosh, Ritwik] Burdwan Med Coll & Hosp, Dept Gen Med, Burdwan, W Bengal, India.
   [Biswas, Payel] Care & Cure Hosp, Dept Radiodiag, Barasat, India.
   [Dubey, Souvik] Inst Post Grad Med Educ & Res, Bangur Inst Neurosci, Dept Neuromed, Kolkata, India.
   [Kalra, Sanjay] SSKM Hosp, Kolkata, India.
   [Kalra, Sanjay] Bharti Hosp, Dept Endocrinol, Karnal, India.
C3 Institute of Post Graduate Medical Education & Research (IPGMER),
   Kolkata; Institute of Post Graduate Medical Education & Research
   (IPGMER), Kolkata
RP Chatterjee, S (corresponding author), Rajendra Inst Med Sci, Dept Gen Med, Ranchi, Bihar, India.
EM chatterjeeaspiresubhankar.92@gmail.com
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NR 247
TC 25
Z9 25
U1 0
U2 8
PU EDIZIONI MINERVA MEDICA
PI TURIN
PA CORSO BRAMANTE 83-85 INT JOURNALS DEPT., 10126 TURIN, ITALY
SN 0391-1977
EI 1827-1634
J9 MINERVA ENDOCRINOL
JI Minerva Endocrinol.
PD SEP
PY 2020
VL 45
IS 3
BP 204
EP 227
DI 10.23736/S0391-1977.20.03216-2
PG 24
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA NZ7CO
UT WOS:000577261900005
PM 32548995
DA 2025-06-11
ER

PT J
AU Wu, YR
   Ma, MY
   Choi, W
   Xu, WF
   Dong, JC
AF Wu, Yueren
   Ma, Mengyu
   Choi, Wenglam
   Xu, Weifang
   Dong, Jingcheng
TI Identification of immune-related gene signatures for chronic obstructive
   pulmonary disease with metabolic syndrome: evidence from integrated bulk
   and single-cell RNA sequencing data
SO INTERNATIONAL IMMUNOLOGY
LA English
DT Article
DE alveolar macrophages; bioinformatics analysis; immune infiltration;
   machine-learning algorithms; reactive oxygen species
ID OXIDATIVE STRESS; COLORECTAL-CANCER; IMPACT; COPD; PATHOPHYSIOLOGY;
   PATHOGENESIS; EXPRESSION; DISORDERS; ZNF331
AB Chronic obstructive pulmonary disease (COPD) is closely related to innate and adaptive inflammatory immune responses. It is increasingly becoming evident that metabolic syndrome (MetS) affects a significant portion of COPD patients. Through this investigation, we identify shared immune-related candidate biological markers. The Weighted Gene Co-Expression Network Analysis (WGCNA) was utilized to reveal the co-expression modules linked to COPD and MetS. The commonly expressed genes in the COPD and MetS were utilized to conduct an enrichment analysis. We adopted machine-learning to screen and validate hub genes. We also assessed the relationship between hub genes and immune cell infiltration in COPD and MetS, respectively. Moreover, associations across hub genes and metabolic pathways were also explored. Finally, we chose a single-cell RNA sequencing (scRNA-seq) dataset to investigate the hub genes and shared mechanisms at the level of the cells. We also applied cell trajectory analysis and cell-cell communication analysis to focus on the vital immune cell we were interested in. As a result, we selected and validated 13 shared hub genes for COPD and MetS. The enrichment analysis and immune infiltration analysis illustrated strong associations between hub genes and immunology. Additionally, we applied metabolic pathway enrichment analysis, indicating the significant role of reactive oxygen species (ROS) in COPD with MetS. Through scRNA-seq analysis, we found that ROS might accumulate the most in the alveolar macrophages. In conclusion, the 13 hub genes related to the immune response and metabolism may serve as diagnostic biomarkers and treatment targets of COPD with MetS.
   Graphical Abstract
C1 [Wu, Yueren; Ma, Mengyu; Choi, Wenglam; Dong, Jingcheng] Fudan Univ, Huashan Hosp, Dept Integrat Med, Shanghai, Peoples R China.
   [Wu, Yueren; Ma, Mengyu; Choi, Wenglam; Dong, Jingcheng] Fudan Univ, Inst Integrat Med, Shanghai, Peoples R China.
   [Xu, Weifang] Guangzhou Univ Chinese Med Futian, Shenzhen Hosp, Shenzhen, Peoples R China.
C3 Fudan University; Fudan University
RP Dong, JC (corresponding author), Fudan Univ, Huashan Hosp, Dept Integrat Med, Shanghai, Peoples R China.; Dong, JC (corresponding author), Fudan Univ, Inst Integrat Med, Shanghai, Peoples R China.; Xu, WF (corresponding author), Guangzhou Univ Chinese Med Futian, Shenzhen Hosp, Shenzhen, Peoples R China.
EM 2487317006@qq.com; jcdong2004@126.com
RI Xu, weifang/HNB-7798-2023
OI Dong, Jingcheng/0000-0002-5194-367X
FU All the authors would like to express their appreciation for the funding
   and thank the research teams for the GEO data cohort who supplied the
   data for this collection.
FX All the authors would like to express their appreciation for the funding
   and thank the research teams for the GEO data cohort who supplied the
   data for this collection.
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NR 53
TC 0
Z9 0
U1 3
U2 10
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0953-8178
EI 1460-2377
J9 INT IMMUNOL
JI Int. Immunol.
PD JAN 29
PY 2024
VL 36
IS 1
BP 17
EP 32
DI 10.1093/intimm/dxad043
EA NOV 2023
PG 16
WC Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology
GA GN5Y6
UT WOS:001097664600001
PM 37878760
DA 2025-06-11
ER

PT J
AU Kobayashi, Y
   Eguchi, A
   Imami, K
   Tempaku, M
   Izuoka, K
   Takase, T
   Kainuma, K
   Nagao, M
   Furuta, N
   Iwasa, M
   Nakagawa, H
   Fujisawa, T
   Togashi, K
AF Kobayashi, Yoshinao
   Eguchi, Akiko
   Imami, Koshi
   Tempaku, Mina
   Izuoka, Kiyora
   Takase, Takafumi
   Kainuma, Keigo
   Nagao, Mizuho
   Furuta, Noriko
   Iwasa, Motoh
   Nakagawa, Hayato
   Fujisawa, Takao
   Togashi, Kenji
TI Circulating extracellular vesicles are associated with
   pathophysiological condition including metabolic syndrome-related
   dysmetabolism in children and adolescents with obesity
SO JOURNAL OF MOLECULAR MEDICINE-JMM
LA English
DT Article
DE Circulating extracellular vesicles; Obesity; Children and adolescents;
   Metabolism; Organ communications
ID FATTY LIVER-DISEASE; CHILDHOOD OBESITY; CELL; INFLAMMATION;
   IDENTIFICATION; ADIPONECTIN; HOMEOSTASIS; RESISTANCE; MUTATIONS; MARKERS
AB Obesity of children and adolescents (OCA) is often accompanied by metabolic syndrome (MetS), which often leads to adult obesity and subsequent complications, yet the entire pathophysiological response is not fully understood. The number and composition of circulating extracellular vesicles (EV) reflect overall patient condition; therefore, we investigated the pathophysiological condition of OCA, including MetS-associated dysmetabolism, using circulating EVs. In total, 107 children and adolescents with or without obesity (boys, n = 69; girls, n = 38; median age, 10 years) were enrolled. Circulating EV number and EV protein composition were assessed via flow cytometry and liquid chromatography tandem-mass spectrometry, respectively. In a multivariate analysis, relative body weight (standardized partial regression coefficient (SPRC) 0.469, P = 0.012) and serum triglyceride level (SPRC 0.548, P < 0.001) were detected as independent parameters correlating with circulating EV number. Proteomic analysis identified 31 upregulated and 45 downregulated EV proteins in OCA. Gene ontology analysis revealed upregulated proteins to be involved in various biological processes, including intracellular protein transport, protein folding, stress response, leukocyte activation, innate immune response, and platelet degranulation, which can modulate lipid and glucose metabolism, skeletal and cardiac muscle development, inflammation, immune response, carcinogenesis, and cancer progression. Notably, several identified EV proteins are involved in neuro-development, neurotransmitter release, and neuro-protective agents in OCA. Circulating EVs were derived from adipocytes, hepatocytes, B cell lymphocytes, and neurons. Circulating EV number is significantly associated with MetS-related dysmetabolism and the EV protein cargo carries a special "signature" that reflects the alteration of various biological processes under the pathophysiological condition of OCA.
C1 [Kobayashi, Yoshinao; Furuta, Noriko] Mie Univ, Grad Sch Med, Ctr Phys & Mental Hlth, Tsu, Mie 5148507, Japan.
   [Kobayashi, Yoshinao; Eguchi, Akiko; Tempaku, Mina; Izuoka, Kiyora; Iwasa, Motoh; Nakagawa, Hayato] Mie Univ, Grad Sch Med, Dept Gastroenterol & Hepatol, 2-174 Edobashi, Tsu, Mie 5148507, Japan.
   [Eguchi, Akiko; Imami, Koshi] JST, PRESTO, 4-1-8 Honcho, Kawaguchi, Saitama 3320012, Japan.
   [Eguchi, Akiko] Mie Univ Hosp, Biobank Ctr, Tsu, Mie 5148507, Japan.
   [Imami, Koshi] Kyoto Univ, Grad Sch Pharmaceut Sci, Kyoto 6068501, Japan.
   [Imami, Koshi] RIKEN, Ctr Integrat Med Sci, Yokohama, Kanagawa 2300045, Japan.
   [Takase, Takafumi; Kainuma, Keigo; Nagao, Mizuho; Fujisawa, Takao] Natl Hosp Org Mie Natl Hosp, Dept Pediat, Tsu, Mie 5140125, Japan.
   [Togashi, Kenji] Mie Univ, Fac Educ, Dept Hlth & Phys Educ, Tsu, Mie 5148507, Japan.
C3 Mie University; Mie University; Japan Science & Technology Agency (JST);
   Mie University; Kyoto University; RIKEN; Mie University
RP Eguchi, A (corresponding author), Mie Univ, Grad Sch Med, Dept Gastroenterol & Hepatol, 2-174 Edobashi, Tsu, Mie 5148507, Japan.; Eguchi, A (corresponding author), JST, PRESTO, 4-1-8 Honcho, Kawaguchi, Saitama 3320012, Japan.; Eguchi, A (corresponding author), Mie Univ Hosp, Biobank Ctr, Tsu, Mie 5148507, Japan.
EM akieguchi@med.mie-u.ac.jp
RI Imami, Koshi/HDN-1392-2022; Nakagawa, Hayato/I-2837-2012
OI Nakagawa, Hayato/0000-0002-6973-5094; Kobayashi,
   Yoshinao/0000-0003-2447-684X
FU The authors would like to thank the paramedical for technical assistance
   at National Hospital Organization Mie National Hospital.; Grants-in-Aid
   for Scientific Research [21K11572, 21K02353] Funding Source: KAKEN
FX The authors would like to thank the paramedical for technical assistance
   at National Hospital Organization Mie National Hospital.
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NR 68
TC 3
Z9 3
U1 0
U2 5
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0946-2716
EI 1432-1440
J9 J MOL MED
JI J. Mol. Med.
PD JAN
PY 2024
VL 102
IS 1
BP 23
EP 38
DI 10.1007/s00109-023-02386-5
EA OCT 2023
PG 16
WC Genetics & Heredity; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Genetics & Heredity; Research & Experimental Medicine
GA FH8J9
UT WOS:001093892800001
PM 37874387
DA 2025-06-11
ER

PT J
AU Dorranipour, D
   Pourjafari, F
   Malekpour-Afshar, R
   Basiri, M
   Hosseini, M
AF Dorranipour, Davood
   Pourjafari, Fahimeh
   Malekpour-Afshar, Reza
   Basiri, Mohsen
   Hosseini, Mehran
TI Assessment of melatonin's therapeutic effectiveness against hepatic
   steatosis induced by a high-carbohydrate high-fat diet in rats
SO NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
LA English
DT Article
DE Melatonin; Obesity; Lipid metabolism; Metabolic syndrome; Non-alcoholic
   fatty liver disease
ID LIVER-DISEASE; METABOLIC SYNDROME; BODY-WEIGHT; OBESITY; LEPTIN; INJURY;
   CELLS; NAFLD
AB Several studies have demonstrated the protective effects of melatonin against metabolic diseases, such as liver steatosis. However, its therapeutic effects have received less scrutiny. The present study aimed to explore melatonin's therapeutic effectiveness in treating non-alcoholic fatty liver disease (NAFLD) induced by a high-carbohydrate high-fat (HCHF) diet in rats. The NAFLD was developed in male Wistar rats using an HCHF diet for 8 weeks. Afterward, they were given melatonin orally for four weeks at doses of 5 mg/kg, 10 mg/kg, and 30 mg/kg, along with the HCHF diet. In addition, six age-matched healthy rats received the highest dose of melatonin (30 mg/kg) for the same duration. Rats on the HCHF diet exhibited obesity, dyslipidemia, hyperglycemia, glucose intolerance, insulin resistance, inflammation, oxidative stress, and liver injury (steatosis). Melatonin treatment at 10 mg/kg and 30 mg/kg reduced body weight, adiposity index, oxidative damage, and inflammation but did not affect impaired glucose metabolism induced by the HCHF diet. Meanwhile, the highest dose of melatonin (30 mg/kg) reduced the liver steatosis index in HCHF rats but caused mild liver damage in healthy rats. In conclusion, using melatonin demonstrated positive outcomes in treating NAFLD induced by the HCHF diet in rats, with no noteworthy effects observed in healthy rats. A moderate dosage of 10 mg/kg of melatonin proved to be a safer and more efficient method for reducing HCHF diet-induced NAFLD in rats. Higher melatonin doses should be cautiously administered due to potential disruptions in lipid metabolism and the risk of liver complications.
C1 [Dorranipour, Davood; Pourjafari, Fahimeh; Basiri, Mohsen; Hosseini, Mehran] Kerman Univ Med Sci, Sch Med, Dept Anat Sci, Kerman, Iran.
   [Malekpour-Afshar, Reza] Kerman Univ Med Sci, Pathol & Stem Cells Res Ctr, Kerman, Iran.
   [Basiri, Mohsen] Kerman Univ Med Sci, Neuropharmacol Inst, Neurosci Res Ctr, Kerman, Iran.
   [Hosseini, Mehran] Birjand Univ Med Sci, Cellular & Mol Res Ctr, Birjand, Iran.
C3 Kerman University of Medical Sciences; Kerman University of Medical
   Sciences; Kerman University of Medical Sciences; Birjand University of
   Medical Sciences
RP Basiri, M; Hosseini, M (corresponding author), Kerman Univ Med Sci, Sch Med, Dept Anat Sci, Kerman, Iran.; Basiri, M (corresponding author), Kerman Univ Med Sci, Neuropharmacol Inst, Neurosci Res Ctr, Kerman, Iran.; Hosseini, M (corresponding author), Birjand Univ Med Sci, Cellular & Mol Res Ctr, Birjand, Iran.
EM basirim@yahoo.com; Mehranhosseiny@yahoo.co.in
RI Afshar, Reza/C-8937-2019; Basiri, Mohsen/AAH-2438-2021; Pourjafari,
   Fahimeh/ABH-8586-2020; Hosseini, Mehran/I-8187-2017
OI Pourjafari, Fahimeh/0000-0003-0046-5919; Hosseini,
   Mehran/0000-0002-6793-2035
FU We acknowledge Dr. Mehdi Sanati for his collaboration in the animal
   study. We thank Mr. Saeed Rastgo for kindly providing us the used stress
   oxidative kits. We acknowledge Ms. Khadijeh Vazifeshenas, laboratory
   technologist in the Core Research Laboratory o; Birjand University of
   Medical Sciences
FX We acknowledge Dr. Mehdi Sanati for his collaboration in the animal
   study. We thank Mr. Saeed Rastgo for kindly providing us the used stress
   oxidative kits. We acknowledge Ms. Khadijeh Vazifeshenas, laboratory
   technologist in the Core Research Laboratory of Birjand University of
   Medical Sciences, for her assistance in ELISA tests. Also, we would like
   to acknowledge the anonymous reviewers for their helpful comments and
   suggestions on the manuscript.
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NR 62
TC 2
Z9 2
U1 3
U2 5
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0028-1298
EI 1432-1912
J9 N-S ARCH PHARMACOL
JI Naunyn-Schmiedebergs Arch. Pharmacol.
PD MAY
PY 2024
VL 397
IS 5
BP 2971
EP 2985
DI 10.1007/s00210-023-02784-z
EA OCT 2023
PG 15
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA PO3O2
UT WOS:001087499800001
PM 37864588
DA 2025-06-11
ER

PT J
AU Steinbrenner, H
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TI The role of selenium in type-2 diabetes mellitus and its metabolic
   comorbidities
SO REDOX BIOLOGY
LA English
DT Article
DE Selenium; Diabetes; Obesity; Metabolic syndrome; NAFLD; Hyperglycemia;
   Hypoglycemia; Glucose; beta-cell
ID HEPATIC INSULIN SENSITIVITY; SELENOPROTEIN P; TOENAIL SELENIUM; CANCER
   PREVENTION; SKELETAL-MUSCLE; SERUM SELENIUM; THR92ALA POLYMORPHISM;
   PROSTATE-CANCER; GENE-EXPRESSION; ADIPOSE-TISSUE
AB This review addresses the role of the essential trace element, selenium, in type-2 diabetes mellitus (T2DM) and its metabolic co-morbidities, i.e., metabolic syndrome, obesity and non-alcoholic fatty liver disease. We refer to the dietary requirements of selenium and the key physiological roles of selenoproteins. We explore the dysregulated fuel metabolism in T2DM and its co-morbidities, emphasizing the relevance of inflammation and oxidative stress. We describe the epidemiology of observational and experimental studies of selenium in diabetes and related conditions, explaining that the interaction between selenium status and glucose control is not limited to hyperglycemia but extends to hypoglycemia. We propose that the association between high plasma/serum selenium and T2DM/fasting plasma glucose observed in many cross-sectional studies may rely on the upregulation of hepatic selenoprotein-P biosynthesis in conditions of hyperglycemia and insulin resistance. While animal studies have revealed potential molecular mechanisms underlying adverse effects of severe selenium/selenoprotein excess and deficiency in the pathogenesis of insulin resistance and beta-cell dysfunction, their translational significance is rather limited. Importantly, dietary selenium supplementation does not appear to be a major causal factor for the development of T2DM in humans though we cannot currently exclude a small contribution of selenium on top of other risk factors, in particular if it is ingested at high (supranutritional) doses. Elevated selenium biomarkers that are often measured in T2DM patients are more likely to be a consequence, rather than a cause, of diabetes.
C1 [Steinbrenner, Holger] Friedrich Schiller Univ, Inst Nutr Sci, Nutrigen Sect, Dornburger Str 29, D-07743 Jena, Germany.
   [Duntas, Leonidas H. H.] Univ Athens, Evgenide Hosp, Unit Endocrinol Metab & Diabet, 20 Papadiamantopoulou Str, Athens 11520, Greece.
   [Rayman, Margaret P. P.] Univ Surrey, Fac Hlth & Med Sci, Dept Nutr Sci, Guildford GU2 7XH, Surrey, England.
C3 Friedrich Schiller University of Jena; National & Kapodistrian
   University of Athens; University of Surrey
RP Rayman, MPP (corresponding author), Univ Surrey, Fac Hlth & Med Sci, Dept Nutr Sci, Guildford GU2 7XH, Surrey, England.
EM m.rayman@surrey.ac.uk
RI Rayman, Margaret/HPC-1602-2023; Duntas, Leonidas/AAL-1476-2021;
   Steinbrenner, Holger/AAD-6323-2019
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NR 141
TC 140
Z9 142
U1 21
U2 172
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2213-2317
J9 REDOX BIOL
JI Redox Biol.
PD APR
PY 2022
VL 50
AR 102236
DI 10.1016/j.redox.2022.102236
EA FEB 2022
PG 13
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 0V3UW
UT WOS:000788272100002
PM 35144052
OA Green Published, gold
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Mari, A
   Khoury, T
   Baker, M
   Ahmad, HS
   Abu Baker, F
   Mahamid, M
AF Mari, Amir
   Khoury, Tawfik
   Baker, Mahamid
   Ahmad, Halel Said
   Abu Baker, Fadi
   Mahamid, Mahmud
TI The Impact of Ramadan Fasting on Fatty Liver Disease Severity: A
   Retrospective Case Control Study from Israel
SO ISRAEL MEDICAL ASSOCIATION JOURNAL
LA English
DT Article
DE fatty liver; liver enzymes; metabolic syndrome; Ramadan fasting
ID AMERICAN ASSOCIATION; METABOLIC SYNDROME; OXIDATIVE STRESS; LIPID
   PROFILE; EPIDEMIOLOGY; MANAGEMENT; INSULIN; GLUCOSE; RISK
AB Background: Non-alcoholic fatty liver disease (NAFLD) is emerging as an important public health condition. The effect of Ramadan fasting on several metabolic conditions has been previously assessed.
   Objectives: To assess the impact of Ramadan fasting on non-alcoholic steatohepatitis (NASH) severity scores.
   Methods: A retrospective, case control study was conducted in Nazareth Hospital between 2017 and 2019. We included NAFLD patients who had been diagnosed by abdominal ultrasonography. The study population was divided in two matched groups: NASH subjects who fasted all of Ramadan and NAFLD/NASH subjects who did not fast (control). Metabolic/NASH severity scores, homeostatic model assessment of beta-cell function and insulin resistance (HOMA-IR), NAFLD Fibrosis Score (NFS), BARD scores, and fibrosis-4 (FIB4) scores were assessed in both groups before and after the Ramadan month.
   Results: The study included 155 NASH subjects, 74 who fasted and 81 who did not. Among the fasting group, body mass index decreased from 36.7 +/- 7.1 to 34.5 +/- 6.8 after fasting (P < 0.003), NFS declined from 0.45 +/- 0.25 to 0.23 +/- 0.21 (P < 0.005), BARD scores declined from 2.3 +/- 0.98 to 1.6 +/- 1.01 (P < 0.005), and FIB4 scores declined from 1.93 +/- 0.76 to 1.34 0.871 (P < 0.005). C-reactive protein decreased from 14.2 +/- 7.1 to 7.18 +/- 6.45 (P < 0.005). Moreover, HOMA-IR improved from 2.92 +/- 1.22 to 2.15 +/- 1.13 (P < 0.005).
   Conclusions: Ramadan fasting improved on inflammatory markers, insulin sensitivity, and noninvasive measures for NASH severity assessment.
C1 [Mari, Amir; Khoury, Tawfik; Baker, Mahamid; Ahmad, Halel Said; Mahamid, Mahmud] Nazareth Hosp EMMS, Dept Gastroenterol & Hepatol, IL-16100 Nazareth, Israel.
   [Khoury, Tawfik] Galilee Med Ctr, Dept Gastroenterol, Nahariyya, Israel.
   [Abu Baker, Fadi] Hillel Yaffe Med Ctr, Dept Gastroenterol & Hepatol, Hadera, Israel.
   [Mahamid, Mahmud] Hebrew Univ Jerusalem, Fac Med, Jerusalem, Israel.
   [Mahamid, Mahmud] Shaare Zedek Med Ctr, Dept Gastroenterol, Jerusalem, Israel.
   [Mari, Amir; Khoury, Tawfik; Baker, Mahamid; Ahmad, Halel Said; Abu Baker, Fadi; Mahamid, Mahmud] Bar Ilan Univ, Fac Med Galilee, Safed, Israel.
C3 Western Galilee Hospital; Hebrew University of Jerusalem; Hebrew
   University of Jerusalem; Shaare Zedek Medical Center; Bar Ilan
   University
RP Mari, A (corresponding author), Nazareth Hosp EMMS, Dept Gastroenterol & Hepatol, IL-16100 Nazareth, Israel.
EM amir.mari@hotmail.com
RI Abu Baker, Fadi/MVX-7023-2025
OI Abu Baker, Fadi/0000-0001-5428-7180
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NR 25
TC 27
Z9 28
U1 0
U2 2
PU ISRAEL MEDICAL ASSOC JOURNAL
PI RAMAT GAN
PA 2 TWIN TOWERS, 11TH FL, 35 JABOTINSKY ST, PO BOX 3604, RAMAT GAN 52136,
   ISRAEL
SN 1565-1088
J9 ISR MED ASSOC J
JI Isr. Med. Assoc. J.
PD FEB
PY 2021
VL 23
IS 2
BP 94
EP 98
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA QX3SH
UT WOS:000629265800006
PM 33595214
DA 2025-06-11
ER

PT J
AU Boaventura, G
   Casimiro-Lopes, G
   Pazos-Moura, CC
   Oliveira, E
   Lisboa, PC
   Moura, EG
AF Boaventura, G.
   Casimiro-Lopes, G.
   Pazos-Moura, C. C.
   Oliveira, E.
   Lisboa, P. C.
   Moura, E. G.
TI Effects of running wheel training on adult obese rats programmed by
   maternal prolactin inhibition
SO JOURNAL OF ENDOCRINOLOGY
LA English
DT Article
DE programming; running wheel; lipid profile; exercise; prolactin; early
   weaning
ID MUSCLE GLYCOGEN; EXERCISE TOLERANCE; LACTATION PROGRAMS; LEPTIN
   RESISTANCE; INTENSITY; STRESS; LIVER; CHOLESTEROL; ADAPTATION;
   OVERWEIGHT
AB The inhibition of maternal prolactin production in late lactation leads to metabolic syndrome and hypothyroidism in adult offspring. Physical training is a therapeutic strategy that could prevent or reverse this condition. We evaluated the effects of a short-duration low-intensity running wheel training program on the metabolic and hormonal alterations in rats. Lactating Wistar rats were treated with bromocriptine (Bro, 1 mg twice a day) or saline on days 19, 20, and 21 of lactation, and the training of offspring began at 35 days of age. Offspring were divided into sedentary and trained controls (C-Sed and C-Ex) and sedentary and trained Bro-treated rats (Bro-Sed and Bro-Ex). Chronic exercise delayed the onset of weight gain in Bro-Ex offspring, and the food intake did not change during the experimental period. At 180 days, visceral fat mass was higher (+46%) in the Bro-Sed offspring than in C-Sed and Bro-Ex rats. As expected, running capacity was higher in trained animals. Most parameters observed in the Bro-Sed offspring were consistent with hypothyroidism and metabolic syndrome and were reversed in the Bro-Ex group. Chronic exercise did not influence the muscle glycogen in the C-Ex group; however, liver glycogen was higher (+30%) in C-Ex group and was unchanged in both Bro offspring groups. Bro-Ex animals had higher plasma lactate dehydrogenase levels, indicating skeletal muscle damage and intolerance of the training program. Low-intensity chronic training is able to normalize many clinical aspects in Bro animals; however, these animals might have had a lower threshold for exercise adaptation than the control rats.
C1 [Boaventura, G.; Casimiro-Lopes, G.; Oliveira, E.; Lisboa, P. C.; Moura, E. G.] Univ Estado Rio de Janeiro, Dept Ciencias Fisiol, Inst Biol Roberto Alcantara Gomes, BR-20551030 Rio De Janeiro, Brazil.
   [Pazos-Moura, C. C.] Univ Fed Rio de Janeiro, Inst Biofis Carlos Chagas Filho, BR-21941 Rio De Janeiro, Brazil.
C3 Universidade do Estado do Rio de Janeiro; Universidade Federal do Rio de
   Janeiro
RP Lisboa, PC (corresponding author), Univ Estado Rio de Janeiro, Dept Ciencias Fisiol, Inst Biol Roberto Alcantara Gomes, 5 Andar,Ave 28 Setembro 87, BR-20551030 Rio De Janeiro, Brazil.
EM pclisboa@uerj.br
RI Moura, Carmen/M-9256-2014; Casimiro-Lopes, Gustavo/C-5502-2008; Moura,
   Egberto/H-1270-2012; Lisboa, Patricia/H-8336-2015
OI Moura, Egberto/0000-0002-1159-7549; Casimiro,
   Gustavo/0000-0002-6329-3918; Lisboa, Patricia/0000-0002-2477-4364
FU National Council for Scientific and Technological Development (Conselho
   Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq));
   Coordination for the Enhancement of Higher Education Personnel
   (Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES));
   State of Rio de Janeiro Carlos Chagas Filho Research Foundation
   (Fundacao Carlos Chagas Filho de Amparo a Pesquisa do Estado do Rio de
   Janeiro (FAPERJ)); CNPq fellowship
FX This research was supported by National Council for Scientific and
   Technological Development (Conselho Nacional de Desenvolvimento
   Cientifico e Tecnologico (CNPq)), Coordination for the Enhancement of
   Higher Education Personnel (Coordenacao de Aperfeicoamento de Pessoal de
   Nivel Superior (CAPES)), and State of Rio de Janeiro Carlos Chagas Filho
   Research Foundation (Fundacao Carlos Chagas Filho de Amparo a Pesquisa
   do Estado do Rio de Janeiro (FAPERJ)). G B was recipient of a CNPq
   fellowship.
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NR 53
TC 4
Z9 4
U1 0
U2 12
PU BIOSCIENTIFICA LTD
PI BRISTOL
PA EURO HOUSE, 22 APEX COURT WOODLANDS, BRADLEY STOKE, BRISTOL BS32 4JT,
   ENGLAND
SN 0022-0795
EI 1479-6805
J9 J ENDOCRINOL
JI J. Endocrinol.
PD OCT
PY 2013
VL 219
IS 1
BP 29
EP 37
DI 10.1530/JOE-13-0102
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 230XO
UT WOS:000325376900006
PM 23863192
OA Bronze
DA 2025-06-11
ER

PT J
AU Druwe, IL
   Sollome, JJ
   Sanchez-Soria, P
   Hardwick, RN
   Camenisch, TD
   Vaillancourt, RR
AF Druwe, Ingrid L.
   Sollome, James J.
   Sanchez-Soria, Pablo
   Hardwick, Rhiannon N.
   Camenisch, Todd D.
   Vaillancourt, Richard R.
TI Arsenite activates NFκB through induction of C-reactive protein
SO TOXICOLOGY AND APPLIED PHARMACOLOGY
LA English
DT Article
DE Arsenite; CRP; Metabolic syndrome
ID DIABETES-MELLITUS; SUBCLINICAL INFLAMMATION; OXIDATIVE STRESS;
   GENE-EXPRESSION; EXPOSURE; RISK; PREVALENCE; ATHEROSCLEROSIS;
   PHOSPHORYLATION; TRANSFORMATION
AB C-reactive protein (CRP) is an acute phase protein in humans. Elevated levels of CRP are produced in response to inflammatory cytokines and are associated with atherosclerosis, hypertension, cardiovascular disease and insulin resistance. Exposure to inorganic arsenic, a common environmental toxicant, also produces cardiovascular disorders, namely atherosclerosis and is associated with insulin-resistance. Inorganic arsenic has been shown to contribute to cardiac toxicities through production of reactive oxygen species (ROS) that result in the activation of NF kappa B. In this study we show that exposure of the hepatic cell line, HepG2, to environmentally relevant levels of arsenite (0.13 to 2 mu M) results in elevated CRP expression and secretion. ROS analysis of the samples showed that a minimal amount of ROS are produced by HepG2 cells in response to these concentrations of arsenic. In addition, treatment of FvB mice with 100 ppb sodium arsenite in the drinking water for 6 months starting at weaning age resulted in dramatically higher levels of CRP in both the liver and inner medullary region of the kidney. Further, mouse Inner Medullary Collecting Duct cells (mIMCD-4), a mouse kidney cell line, were stimulated with 10 ng/ml CRP which resulted in activation of NF kappa B. Pretreatment with 10 nM Y27632, a known Rho-kinase inhibitor, prior to CRP exposure attenuated NF kappa B activation. These data suggest that arsenic causes the expression and secretion of CRP and that CRP activates NF kappa B through activation of the Rho-kinase pathway, thereby providing a novel pathway by which arsenic can contribute to metabolic syndrome and cardiovascular disease. (C) 2012 Elsevier Inc. All rights reserved.
C1 [Druwe, Ingrid L.; Sollome, James J.; Sanchez-Soria, Pablo; Hardwick, Rhiannon N.; Camenisch, Todd D.; Vaillancourt, Richard R.] Univ Arizona, Dept Pharmacol & Toxicol, Coll Pharm, Tucson, AZ 85721 USA.
C3 University of Arizona
RP Vaillancourt, RR (corresponding author), Univ Arizona, Dept Pharmacol & Toxicol, Coll Pharm, 1703 E Mabel St, Tucson, AZ 85721 USA.
EM vaillancourt@pharmacy.arizona.edu
OI Hardwick, Rhiannon/0000-0001-9052-1309; Camenisch,
   Todd/0000-0002-7797-9822; Druwe, Ingrid/0000-0002-0591-0295
FU NIEHS Superfund Basic Research Program Grant [ES 04940]; NIH NRSA Grant
   [ES 016990]; NIEHS Center Grant [ES 006694]
FX This work was supported by NIEHS Superfund Basic Research Program Grant
   (ES 04940), NIH NRSA Grant (ES 016990), and NIEHS Center Grant (ES
   006694).
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NR 54
TC 21
Z9 27
U1 0
U2 11
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0041-008X
EI 1096-0333
J9 TOXICOL APPL PHARM
JI Toxicol. Appl. Pharmacol.
PD JUN 15
PY 2012
VL 261
IS 3
BP 263
EP 270
DI 10.1016/j.taap.2012.04.005
PG 8
WC Pharmacology & Pharmacy; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Toxicology
GA 961XK
UT WOS:000305502600005
PM 22521605
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Hartwich, J
   Malec, MM
   Partyka, L
   Pérez-Martinez, P
   Marin, C
   López-Miranda, J
   Tierney, AC
   Mc Monagle, J
   Roche, HM
   Defoort, C
   Wolkowe, P
   Dembinska-Kiec, A
AF Hartwich, Jadwiga
   Malec, Malgorzata Malczewska
   Partyka, Lukasz
   Perez-Martinez, Pablo
   Marin, Carmen
   Lopez-Miranda, Jose
   Tierney, Audrey C.
   Mc Monagle, Jolene
   Roche, Helen M.
   Defoort, Catherine
   Wolkowe, Pawel
   Dembinska-Kiec, Aldona
TI The effect of the plasma n-3/n-6 polyunsaturated fatty acid ratio on the
   dietary LDL phenotype transformation - Insights from the LIPGENE study
SO CLINICAL NUTRITION
LA English
DT Article
DE n3/n6 Polyunsaturated fatty acid ratio; LDL phenotype; Dietary
   intervention
ID LOW-DENSITY-LIPOPROTEIN; LONG-CHAIN; SUBCLASS PATTERNS; TRANSFER
   PROTEIN; PARTICLE-SIZE; SUBFRACTIONS; DISEASE; RISK
AB Background & aims: LDL phenotype B is associated with obesity, insulin resistance, hypertriglyceridemia and oxidative stress. The effect of plasma n-3/n-6 PUFA ratio on LDL phenotype transformation was investigated.
   Methods: Patients with metabolic syndrome (n = 99) received one of four isocaloric diets: (A) High-fat (38% energy) SFA-rich diet (HSFA); (B) High-fat (38% energy), MUFA-rich diet (HMUFA): (C), low-fat (LF) high-complex carbohydrate diet with 1.24 g/d oleic sunflower oil (LFHCC) and (D): low-fat (28% energy), (28% energy), high-complex carbohydrate diet, with 1.24g/d LC n-3 PUFA (LFHCC n-3) for 12 weeks. Analysis of plasma lipid profile and LDL phenotype was done pre- and post-interventions.
   Results: Post-dietary change of LDL density was a main effect observed in all groups. LFHCC n-3 and HFMUFA diets resulted in favorable alteration of LDL phenotype from B to A and decreased LDL density. In contrast, increased LDL density was observed in HSFA and LFHCC groups. The plasma pre-n3/n6 PUFA, Apo E change and pre-Apo CIII/CII ratios explained in 65% the post-dietary change of LDL density in diet LFHCC n-3 consumers.
   Conclusions: Study demonstrates efficacy of dietary n-3 PUFA to modify pro-atherogenic to less atherogenic LDL phenotype in patients with metabolic syndrome. Study identifier at ClinicalTrials.gov was NCT00429195. (C) 2009 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.
C1 [Hartwich, Jadwiga; Malec, Malgorzata Malczewska; Partyka, Lukasz; Dembinska-Kiec, Aldona] Jagiellonian Univ, Sch Med, Dept Clin Biochem, PL-30688 Krakow, Poland.
   [Perez-Martinez, Pablo; Marin, Carmen; Lopez-Miranda, Jose] Univ Cordoba, Sch Med, Reina Sofia Univ Hosp, Cordoba, Spain.
   [Tierney, Audrey C.; Mc Monagle, Jolene; Roche, Helen M.] Natl Univ Ireland Univ Coll Dublin, UCD Conway Inst, Nutrigenom Res Grp, Dublin 4, Ireland.
   [Defoort, Catherine] INSERM, U476, F-13258 Marseille, France.
   [Wolkowe, Pawel] Jagiellonian Univ, Sch Med, Dept Pharmacol, PL-30688 Krakow, Poland.
C3 Jagiellonian University; Hospital Universitario Reina Sofia - Cordoba;
   Universidad de Cordoba; University College Dublin; Institut National de
   la Sante et de la Recherche Medicale (Inserm); Jagiellonian University
RP Hartwich, J (corresponding author), Jagiellonian Univ, Coll Med, Dept Analyt Biochem, Fac Pharm, Med 9, PL-30688 Krakow, Poland.
EM mbhartwi@cyf-kr.edu.pl
RI Partyka, Lukasz/F-9567-2014; Lopez-Miranda, Jose/Y-8306-2019; Roche,
   Helen/AAF-4164-2019; Tierney, Audrey/AAB-7068-2022; Marin Hinojosa,
   Carmen/AFO-1294-2022; Wolkow, Pawel/AAI-4222-2021; Perez Martinez,
   Pablo/AEL-6176-2022
OI Perez Martinez, Pablo/0000-0001-7716-8117; Tierney,
   Audrey/0000-0001-8562-2877; Roche, Helen/0000-0002-0628-3318; Wolkow,
   Pawel/0000-0002-9322-5545; Lopez-Miranda, Jose/0000-0002-8844-0718
FU EU [FP6 FOOD-CF-2003-505944]
FX This work was supported by EU FP6 FOOD-CF-2003-505944 LIPGENE project.r
   The Authors acknowledge Drs. Brita Karlstrom, Ulf Riserus and Prof.
   Bengt Vessby for expert analysis of isoprostane levels in subject
   samples.r Statement of authorship.r JH conceived of the study, and
   participated in its design, carried out samples and data analyses and
   drafted the manuscript. MMM & PPM participated in study design, conduct
   and subject enrollment. LP participated in study design, conduct,
   subject enrollment and manuscript revision. CM, ACT, JMM, CD carried out
   the samples analyses. JLM participated in the design of the study and
   performed the statistical analysis together with JH and PW. HM and ADK
   participated in study design and coordination and helped to draft the
   manuscript. All authors read and approved the final manuscript.
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NR 31
TC 18
Z9 21
U1 0
U2 10
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0261-5614
EI 1532-1983
J9 CLIN NUTR
JI Clin. Nutr.
PD OCT
PY 2009
VL 28
IS 5
BP 510
EP 515
DI 10.1016/j.clnu.2009.04.016
PG 6
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 518IQ
UT WOS:000271685100005
PM 19481310
DA 2025-06-11
ER

PT J
AU Rumora, AE
   Kim, B
   Feldman, EL
AF Rumora, Amy E.
   Kim, Bhumsoo
   Feldman, Eva L.
TI A Role for Fatty Acids in Peripheral Neuropathy Associated with Type 2
   Diabetes and Prediabetes
SO ANTIOXIDANTS & REDOX SIGNALING
LA English
DT Review
DE fatty acids; neuropathy; diabetes; prediabetes; dyslipidemia
ID INDUCED OXIDATIVE STRESS; ACETYL-COA CARBOXYLASE; DORSAL-ROOT GANGLIA;
   NERVOUS-SYSTEM; METABOLIC SYNDROME; BINDING PROTEINS; MICROVASCULAR
   COMPLICATIONS; LIPOPROTEIN-LIPASE; LIPID HOMEOSTASIS; GENE-EXPRESSION
AB Significance: As the global prevalence of diabetes rises, diabetic complications are also increasing at an alarming rate. Peripheral neuropathy (PN) is the most prevalent complication of diabetes and prediabetes, and is characterized by progressive sensory loss resulting from nerve damage. While hyperglycemia is the major risk factor for PN in type 1 diabetes (T1D), the metabolic syndrome (MetS) underlies the onset and progression of PN in type 2 diabetes (T2D) and prediabetes.Recent Advances: Recent reports show that dyslipidemia, a MetS component, is strongly associated with PN in T2D and prediabetes. Dyslipidemia is characterized by an abnormal plasma lipid profile with uncontrolled lipid levels, and both clinical and preclinical studies implicate a role for dietary fatty acids (FAs) in PN pathogenesis. Molecular studies further show that saturated and unsaturated FAs differentially regulate the nerve lipid profile and nerve function.Critical Issues: We first review the properties of FAs and the neuroanatomy of the peripheral nervous system (PNS). Second, we discuss clinical and preclinical studies that implicate the involvement of FAs in PN. Third, we summarize the potential effects of FAs on nerve function and lipid metabolism within the peripheral nerves, sensory neurons, and Schwann cells.Future Directions: Future directions will focus on identifying molecular pathways in T2D and prediabetes that are modulated by FAs in PN. Determining pathophysiological mechanisms that underlie the injurious effects of saturated FAs and beneficial properties of unsaturated FAs will provide mechanistic targets for developing new targeted therapies to treat PN associated with T2D and prediabetes.
C1 [Rumora, Amy E.] Columbia Univ, Dept Neurol, 630 W 168th St,P&S Bldg 5-401, New York, NY 10032 USA.
   [Rumora, Amy E.; Kim, Bhumsoo; Feldman, Eva L.] Univ Michigan, Dept Neurol, Ann Arbor, MI USA.
C3 Columbia University; University of Michigan System; University of
   Michigan
RP Rumora, AE (corresponding author), Columbia Univ, Dept Neurol, 630 W 168th St,P&S Bldg 5-401, New York, NY 10032 USA.
EM aer2219@cumc.columbia.edu
FU National Institutes of Health (NIH) National Institute of Diabetes and
   Digestive and Kidney Disease (NIDDK) [1R24DK082841, 1R21NS102924,
   1F32DK112642, K99/R00 DK119366]; e American Diabetes Asso-ciation
   [7-12-BS-045]; Neuro-Network for Emerging Therapies; A. Alfred Taubman
   Medical Research Institute
FX This work was supported by the National Institutes of Health (NIH)
   National Institute of Diabetes and Digestive and Kidney Disease (NIDDK)
   grant numbers 1R24DK082841 and 1R21NS102924 (to E.L.F.) and 1F32DK112642
   and K99/R00 DK119366 (to A.E.R.); the American Diabetes Asso-ciation
   [grant number 7-12-BS-045] (to E.L.F.); the Neuro-Network for Emerging
   Therapies; and the A. Alfred Taubman Medical Research Institute
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NR 145
TC 8
Z9 8
U1 0
U2 31
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1523-0864
EI 1557-7716
J9 ANTIOXID REDOX SIGN
JI Antioxid. Redox Signal.
PD SEP 1
PY 2022
VL 37
IS 7-9
BP 560
EP 577
DI 10.1089/ars.2021.0155
EA APR 2022
PG 18
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 6D9DT
UT WOS:000808446400001
PM 35152728
OA Green Published
DA 2025-06-11
ER

PT J
AU Rabaglino, MB
   Moreira-Espinoza, MJ
   Lagares, C
   Garay, MI
   Quiroga, P
   Pasqualini, ME
   Francini, F
   Beltramo, D
AF Belen Rabaglino, Maria
   Jose Moreira-Espinoza, Maria
   Lagares, Clarisa
   Isabel Garay, Maria
   Quiroga, Patricia
   Eugenia Pasqualini, Maria
   Francini, Flavio
   Beltramo, Dante
TI Maternal intake of alpha-lipoic acid prevents development of symptoms
   associated with a fructose-rich diet in the male offspring in Wistar
   rats
SO JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE
LA English
DT Article
DE Fetal programming; metabolic syndrome; metabolism; antioxidants
ID INDUCED METABOLIC SYNDROME; OXIDATIVE STRESS; INSULIN-RESISTANCE;
   ORIGINS; TISSUE; METAANALYSIS; GLUCOSE; OBESITY; CELLS
AB The hypothesis was that maternal intake of the antioxidant alpha-lipoid acid (ALA), during the developmental period of the hypothalamic orexigenic neurons, causes a permanent beneficial effect in offspring metabolism. Pregnant Wistar rats were fed with standard diet (food) + ALA (0.4% wt/wt) from day 14 of gestation to day 20 of lactation (n = 4) or food (n = 4). At 3 months of age, male offspring born from ALA-fed rats or controls (CT) were randomly assigned to be fed with food + 10% fructose solution in drinking water (F) or food + tap water (C), resulting in four groups: ALAF, ALAC, CTF, and CTC (n = 5/group). Food intake and body weight (BW) were measured twice a week for 31 days. Metabolites' levels in blood, mRNA expressions of Npy, Agrp (hypothalamus), Fasn, Srebf1, Ppard, and Pparg (liver), and the antioxidant capacity of the liver were determined. Results significance was set at p < 0.05. Average BW gain, daily BW gain, and intraabdominal fat tissue at necropsy were higher in CTF group followed by CTC, ALAF, and ALAC groups. There were no differences between groups in Kcal intake per day. mRNA expressions of hypothalamic and hepatic genes and plasmatic levels of glucose and triglycerides were higher in CTF group followed by ALAF, CTC, and ALAC groups. Fructose intake affected the oxidative capacity of the liver, but this effect was not observed in the ALAF group. In conclusion, maternal ALA intake protected the adult offspring to develop metabolic symptoms associated with high fructose in the drinking water.
C1 [Belen Rabaglino, Maria; Jose Moreira-Espinoza, Maria; Lagares, Clarisa; Isabel Garay, Maria; Eugenia Pasqualini, Maria] Univ Nacl Cordoba, Inst Invest Ciencias Salud INICSA CONICET, Pabellon Biol Celular, RA-5000 Cordoba, Argentina.
   [Jose Moreira-Espinoza, Maria; Isabel Garay, Maria; Quiroga, Patricia; Eugenia Pasqualini, Maria] Univ Nacl Cordoba, Fac Ciencias Med, Catedra Biol Celular Histol & Embriol, Inst Biol Celular IBC UNC, RA-5000 Cordoba, Argentina.
   [Francini, Flavio] UNLP CONICET FCM, Ctr Endocrinol Expt & Aplicada CENEXA, RA-1900 La Plata, Argentina.
   [Beltramo, Dante] Consejo Nacl Invest Cient & Tecn, CEPROCOR, Av Alvarez Arenales 180, RA-5004 Cordoba, Argentina.
C3 National University of Cordoba; National University of Cordoba; Consejo
   Nacional de Investigaciones Cientificas y Tecnicas (CONICET)
RP Rabaglino, MB (corresponding author), Univ Nacl Cordoba, Inst Invest Ciencias Salud INICSA CONICET, Pabellon Biol Celular, RA-5000 Cordoba, Argentina.
EM belenrabaglino@icloud.com
RI LAGARES, CLARISA/LOS-5084-2024
OI Rabaglino, Maria Belen/0000-0002-0099-045X; Moreira-Espinoza, Maria
   Jose/0000-0003-2398-296X
FU CONICET [PIP 11220150100947]
FX This study was partially supported with a grant from CONICET to MBR and
   DB (PIP 11220150100947).
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NR 52
TC 6
Z9 6
U1 0
U2 5
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 2040-1744
EI 2040-1752
J9 J DEV ORIG HLTH DIS
JI J. Dev. Orig. Health Dis.
PD OCT
PY 2021
VL 12
IS 5
BP 758
EP 767
AR PII S2040174420001178
DI 10.1017/S2040174420001178
PG 10
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA UM2YX
UT WOS:000693202800011
PM 33303040
DA 2025-06-11
ER

PT J
AU Nyavor, Y
   Estill, R
   Edwards, H
   Ogden, H
   Heideman, K
   Starks, K
   Miller, C
   May, G
   Fleschl, L
   McMillan, J
   Gericke, M
   Forney, L
   Balemba, O
AF Nyavor, Yvonne
   Estill, Rachel
   Edwards, Hannah
   Ogden, Hailey
   Heideman, Kaila
   Starks, Kiefer
   Miller, Christopher
   May, George
   Fleschl, Lance
   McMillan, John
   Gericke, Martin
   Forney, Larry
   Balemba, Onesmo
TI Intestinal nerve cell injury occurs prior to insulin resistance in
   female mice ingesting a high-fat diet
SO CELL AND TISSUE RESEARCH
LA English
DT Article
DE Gut microbiota; Diabetes mellitus; Gastrointestinal motility; Enteric
   nervous system; Diabetic enteric neuropathy
ID GASTROINTESTINAL MOTILITY DISORDERS; GUT MICROBIOTA;
   NEUROMUSCULAR-TRANSMISSION; METABOLIC SYNDROME; OXIDATIVE STRESS;
   INDUCED OBESITY; NEUROPATHY; DISEASE; TRANSIT; SYSTEM
AB Diabetic patients suffer from gastrointestinal disorders associated with dysmotility, enteric neuropathy and dysbiosis of gut microbiota; however, gender differences are not fully known. Previous studies have shown that a high-fat diet (HFD) causes type two diabetes (T2D) in male mice after 4-8weeks but only does so in female mice after 16weeks. This study seeks to determine whether sex influences the development of intestinal dysmotility, enteric neuropathy and dysbiosis in mice fed HFD. We fed 8-week-old C57BL6 male and female mice a standard chow diet (SCD) or a 72% kcal HFD for 8weeks. We analyzed the associations between sex and intestinal dysmotility, neuropathy and dysbiosis using motility assays, immunohistochemistry and next-generation sequencing. HFD ingestion caused obesity, glucose intolerance and insulin resistance in male but not female mice. However, HFD ingestion slowed intestinal propulsive motility in both male and female mice. This was associated with decreased inhibitory neuromuscular transmission, loss of myenteric inhibitory motor neurons and axonal swelling and loss of cytoskeletal filaments. HFD induced dysbiosis and changed the abundance of specific bacteria, especially Allobaculum, Bifidobacterium and Lactobacillus, which correlated with dysmotility and neuropathy. Female mice had higher immunoreactivity and numbers of myenteric inhibitory motor neurons, matching larger amplitudes of inhibitory junction potentials. This study suggests that sex influences the development of HFD-induced metabolic syndrome but dysmotility, neuropathy and dysbiosis occur independent of sex and prior to T2D conditions. Gastrointestinal dysmotility, neuropathy and dysbiosis might play a crucial role in the pathophysiology of T2D in humans irrespective of sex.
C1 [Nyavor, Yvonne; Estill, Rachel; Edwards, Hannah; Ogden, Hailey; Heideman, Kaila; Starks, Kiefer; Miller, Christopher; May, George; Fleschl, Lance; McMillan, John; Forney, Larry; Balemba, Onesmo] Univ Idaho, Dept Biol Sci, 75 Perimeter Dr,LSS 252, Moscow, ID 83844 USA.
   [Gericke, Martin] Univ Leipzig, Inst Anat, Liebigstr 13, D-04103 Leipzig, Germany.
C3 University of Idaho; Leipzig University
RP Balemba, O (corresponding author), Univ Idaho, Dept Biol Sci, 75 Perimeter Dr,LSS 252, Moscow, ID 83844 USA.
EM obalemba@uidaho.edu
RI Nyavor, Yvonne/ABA-6939-2020; Gericke, Martin/AAI-8637-2020
OI Starks, Kiefer/0009-0008-3345-9383
FU University of Idaho-Dyess Faculty Fellowship; Institutional Development
   Awards (IDeA) from the National Institute of General Medical Sciences of
   the National Institutes of Health [P30GM103324, P20 GM103408]
FX The research reported in this publication was supported by the
   University of Idaho-Dyess Faculty Fellowship and Institutional
   Development Awards (IDeA) from the National Institute of General Medical
   Sciences of the National Institutes of Health under grant numbers
   P30GM103324 and P20 GM103408.
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NR 60
TC 22
Z9 25
U1 0
U2 15
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0302-766X
EI 1432-0878
J9 CELL TISSUE RES
JI Cell Tissue Res.
PD JUN
PY 2019
VL 376
IS 3
BP 325
EP 340
DI 10.1007/s00441-019-03002-0
PG 16
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA HZ6AP
UT WOS:000468934500002
PM 30778729
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Yan, PJ
   Xu, Y
   Wan, Q
   Feng, J
   Li, H
   Yang, J
   Zhong, HH
   Zhang, ZH
AF Yan, Pijun
   Xu, Yong
   Wan, Qin
   Feng, Jian
   Li, Hua
   Yang, Jun
   Zhong, Haihua
   Zhang, Zhihong
TI Plasma Neuregulin 4 Levels Are Associated with Metabolic Syndrome in
   Patients Newly Diagnosed with Type 2 Diabetes Mellitus
SO DISEASE MARKERS
LA English
DT Article
ID GAMMA-GLUTAMYL-TRANSFERASE; INSULIN-RESISTANCE; ADIPOSE-TISSUE; BROWN;
   NRG4; RISK; ADIPONECTIN; HOMEOSTASIS; APOPTOSIS; DISEASE
AB Neuregulin 4 (Nrg4) has been proposed to play a role in the pathogeneses of obesity, insulin resistance, and dyslipidemia. However, information about the link between Nrg4 and metabolic syndrome (MetS) is scarce, especially in patients with newly diagnosed type 2 diabetes mellitus (nT2DM). This study aimed at investigating whether Nrg4 is associated with MetS in nT2DM patients. A total of 311 patients with nT2DM were recruited. Plasma Nrg4 concentration was determined by ELISA. Plasma Nrg4 concentration was lower in nT2DM patients with MetS than in nT2DM patients without MetS (P = 0 001). Nrg4 concentration showed negative correlations with most of the analyzed indicators of MetS. MetS was less prevalent among subjects in the highest quartile of plasma Nrg4 concentration than among those in the lowest quartile (P < 0 01). Age-and sex-adjusted plasma Nrg4 concentrations were positively correlated with concentrations of high-density lipoprotein cholesterol (HDL-C) and apolipoprotein A (both P < 0 05) and negatively correlated with triglyceride, high-sensitivity C-reactive protein (hs-CRP), and gamma-glutamyltransferase concentrations, neutrophil count, and white blood cell (WBC) count (all P < 0 05). In multivariate analysis, Nrg4 was independently associated with hs-CRP level, WBC count, and HDL-C level (P = 0 001 or P < 0 05). Multiple logistic regression analysis of MetS prediction by Nrg4 revealed an odds ratio of 0.560 (95% CI: 0.374-0.837; P < 0 01). Decreased plasma Nrg4 levels, which may be associated with augmented oxidative stress, inflammation, and dyslipidemia, might be involved in the development of MetS in nT2DM patients.
C1 [Yan, Pijun; Xu, Yong; Wan, Qin; Li, Hua; Yang, Jun; Zhong, Haihua] Southwest Med Univ, Affiliated Hosp, Dept Endocrinol, Luzhou 646000, Sichuan, Peoples R China.
   [Feng, Jian] Southwest Med Univ, Affiliated Hosp, Dept Cardiovasc Med, Luzhou 646000, Sichuan, Peoples R China.
   [Zhang, Zhihong] Southwest Med Univ, Affiliated Hosp, Dept Gen Med, Luzhou 646000, Sichuan, Peoples R China.
C3 Southwest Medical University; Southwest Medical University; Southwest
   Medical University
RP Zhang, ZH (corresponding author), Southwest Med Univ, Affiliated Hosp, Dept Gen Med, Luzhou 646000, Sichuan, Peoples R China.
EM zhihonglily@126.com
RI Xu, Yong/AGX-9165-2022; Feng, Jian/GSM-6804-2022
OI Xu, Yong/0000-0002-9534-6252
FU Ministry of Science and Technology of China [2016YFC0901200,
   2016YFC0901205]; National Natural Science Foundation of China
   [31300946]; Health and Family Planning Commission of Sichuan Province
   [16129]; Sichuan Province Science and Technology Department [Z1448];
   Luzhou Science and Technology Bureau [2013-S-48 (22/30)]
FX The authors appreciate the contributions of all of their colleagues in
   the Clinical Laboratory Center and Endocrine Laboratory and the hard
   work of all of the nurses in their department. This study is supported
   by the Grants 2016YFC0901200 and 2016YFC0901205 from the Ministry of
   Science and Technology of China and research grants from the National
   Natural Science Foundation of China (31300946), Health and Family
   Planning Commission of Sichuan Province (16129), Sichuan Province
   Science and Technology Department (Z1448), and Luzhou Science and
   Technology Bureau [2013-S-48 (22/30)].
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NR 44
TC 42
Z9 44
U1 1
U2 16
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 0278-0240
EI 1875-8630
J9 DIS MARKERS
JI Dis. Markers
PY 2018
VL 2018
AR 6974191
DI 10.1155/2018/6974191
PG 11
WC Biotechnology & Applied Microbiology; Genetics & Heredity; Medicine,
   Research & Experimental; Pathology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Genetics & Heredity; Research &
   Experimental Medicine; Pathology
GA GA5TD
UT WOS:000428395700001
PM 29721105
OA hybrid, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Acay, A
   Erdenen, F
   Altunoglu, E
   Erman, H
   Muderrisoglu, C
   Korkmaz, GG
   Gelisgen, R
   Tabak, O
   Uzun, H
AF Acay, A.
   Erdenen, F.
   Altunoglu, E.
   Erman, H.
   Muderrisoglu, C.
   Korkmaz, G. G.
   Gelisgen, R.
   Tabak, O.
   Uzun, H.
TI Evaluation of Serum Paraoxonase and Arylesterase Activities in Subjects
   with Asthma and Chronic Obstructive Lung Disease
SO CLINICAL LABORATORY
LA English
DT Article
DE asthma; chronic obstructive lung disease; paraoxonase; arylesterase
ID OXIDATIVE STRESS; PULMONARY-DISEASE; RHEUMATOID-ARTHRITIS; TURKISH
   POPULATION; METABOLIC SYNDROME; INFLAMMATION; MARKERS; ATHEROSCLEROSIS;
   COMORBIDITIES; OBESITY
AB Background: Asthma and chronic obstructive lung disease (COPD) are characterised by airway inflammation. Paraoxonase1 (PON1) and arylesterase (AE) enzymes have the ability to protect HDL from oxidation and may have antiatherogenic, antioxidant, and antiinflammatory features. We carried out a study to assess if there is a difference between PON1 and AE activities and biochemical values between asthmatics and COPD patients and if there is a difference between comorbid or pure COPD patients.
   Methods: 40 asthmatics, 20 pure COPD, 20 comorbid COPD patients, and 20 healthy controls were included. We excluded patients with hypertension, metabolic syndrome, diabetes mellitus, thyroid, renal, hepatic, rheumatic, cardiac, cerebrovascular, malignant, and infectious diseases to establish the asthma and pure COPD groups. Patients using drugs which could affect PON1 and AE were excluded in these groups. There were 11 hypertensive, 5 diabetic, and 4 cardiac patients in the comorbid COPD group. PON1 and AE activities were measured spectrophotometrically.
   Results: Mean age was higher and male gender was more prevalant in COPD than other groups. Fasting blood glucose, LDL-cholesterol, triglyceride, leucocyte counts, erythrocyte sedimentation rate, and hs-CRP levels were higher in COPD patients. Although PON1 and AE were lower in patients than controls, no difference was found between the asthma and COPD groups, nor between pure and comorbid COPD patients.
   Conclusions: Although asthma and COPD are two different conditions PON1 and AE activities cannot be markers of differantial diagnosis as they overlap. Comorbid COPD patients may have similar enzyme levels because of the drugs such as statins and aspirin.
C1 [Acay, A.; Erdenen, F.; Altunoglu, E.; Muderrisoglu, C.] Istanbul Educ & Res Hosp, Internal Med Clin, Istanbul, Turkey.
   [Erman, H.; Gelisgen, R.; Uzun, H.] Istanbul Univ, Cerrahpasa Med Fac, Dept Biochem, Istanbul, Turkey.
   [Korkmaz, G. G.] Kirklareli Univ, Sch Hlth, Kirklareli, Turkey.
   [Tabak, O.] Istanbul Kanuni Sultan Suleyman Educ & Res Hosp, Internal Med Clin, Istanbul, Turkey.
C3 Istanbul Training & Research Hospital; Istanbul University - Cerrahpasa;
   Istanbul University; Kirklareli University; Istanbul Kanuni Sultan
   Suleyman Training & Research Hospital
RP Uzun, H (corresponding author), Cerrahpasa Tip Fak, Temel Bilimler Tibbi Biyokimya Anabilim Dali, TR-34303 Cerrahpasa, Turkey.
EM huzun59@hotmail.com
RI Uzun, Hakan/AFV-8480-2022; Uzun, Hafize/D-4811-2019; Guntas,
   Gulcan/B-9262-2014; Gelisgen, Remise/D-2983-2019
OI Uzun, Hafize/0000-0002-1347-8498; Guntas, Gulcan/0000-0002-3638-4662;
   Gelisgen, Remise/0000-0003-4121-5107
CR [Anonymous], POCK GUID COPD DIAGN
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NR 33
TC 15
Z9 16
U1 0
U2 15
PU CLIN LAB PUBL
PI HEIDELBERG
PA IM BREITSPIEL 15, HEIDELBERG, D-69126, GERMANY
SN 1433-6510
J9 CLIN LAB
JI Clin. Lab.
PY 2013
VL 59
IS 11-12
BP 1331
EP 1337
DI 10.7754/Clin.Lab.2013.121144
PG 7
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA 276CG
UT WOS:000328725100016
PM 24409668
DA 2025-06-11
ER

PT J
AU Odermatt, A
AF Odermatt, Alex
TI The Western-style diet: a major risk factor for impaired kidney function
   and chronic kidney disease
SO AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
LA English
DT Review
DE metabolic syndrome; fructose; fat; salt; glucocorticoid
ID 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1; ACTIVATED PROTEIN-KINASE;
   NECROSIS-FACTOR-ALPHA; NF-KAPPA-B; RENAL LIPID-ACCUMULATION; TUBULE
   NA+/H+ EXCHANGE; MODEST SALT REDUCTION; SMOOTH-MUSCLE-CELLS; METABOLIC
   SYNDROME; URIC-ACID
AB Odermatt A. The Western-style diet: a major risk factor for impaired kidney function and chronic kidney disease. Am J Physiol Renal Physiol 301: F919-F931, 2011. First published August 31, 2011; doi:10.1152/ajprenal.00068.2011.-The Western-style diet is characterized by its highly processed and refined foods and high contents of sugars, salt, and fat and protein from red meat. It has been recognized as the major contributor to metabolic disturbances and the development of obesity-related diseases including type 2 diabetes, hypertension, and cardiovascular disease. Also, the Western-style diet has been associated with an increased incidence of chronic kidney disease (CKD). A combination of dietary factors contributes to the impairment of renal vascularization, steatosis and inflammation, hypertension, and impaired renal hormonal regulation. This review addresses recent progress in the understanding of the association of the Western-style diet with the induction of dyslipidemia, oxidative stress, inflammation, and disturbances of corticosteroid regulation in the development of CKD. Future research needs to distinguish between acute and chronic effects of diets with high contents of sugars, salt, and fat and protein from red meat, and to uncover the contribution of each component. Improved therapeutic interventions should consider potentially altered drug metabolism and pharmacokinetics and be combined with lifestyle changes. A clinical assessment of the long-term risks of whole-body disturbances is strongly recommended to reduce metabolic complications and cardiovascular risk in kidney donors and patients with CKD.
C1 Univ Basel, Div Mol & Syst Toxicol, Dept Pharmaceut Sci, CH-4056 Basel, Switzerland.
C3 University of Basel
RP Odermatt, A (corresponding author), Univ Basel, Div Mol & Syst Toxicol, Dept Pharmaceut Sci, Klingelbergstr 50, CH-4056 Basel, Switzerland.
EM alex.odermatt@unibas.ch
OI Odermatt, Alex/0000-0002-6820-2712
FU NCCR Kidney.CH; Swiss National Science Foundation
FX This work was supported by NCCR Kidney.CH, funded by the Swiss National
   Science Foundation.
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   Zhao HL, ACTA DIABETOL
NR 158
TC 201
Z9 219
U1 1
U2 46
PU AMER PHYSIOLOGICAL SOC
PI Rockville
PA 6120 Executive Blvd, Suite 600, Rockville, MD, UNITED STATES
SN 1931-857X
EI 1522-1466
J9 AM J PHYSIOL-RENAL
JI Am. J. Physiol.-Renal Physiol.
PD NOV
PY 2011
VL 301
IS 5
BP F919
EP F931
DI 10.1152/ajprenal.00068.2011
PG 13
WC Physiology; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology; Urology & Nephrology
GA 863GV
UT WOS:000298151700001
PM 21880837
DA 2025-06-11
ER

PT J
AU Gunetilleke, B
AF Gunetilleke, Bhagya
TI A Quest for Enhanced Recovery After Liver Transplant at The Colombo
   North Center for Liver Disease: The First Decade
SO SRI LANKAN JOURNAL OF ANAESTHESIOLOGY
LA English
DT Article
DE Enhanced recovery after surgery (ERAS); liver transplant
ID CRYPTOGENIC CIRRHOSIS; EXPERIENCE; ANESTHESIA; SURGERY
AB Cirrhosis is a significant contributor to non-communicable disease related deaths in Sri Lanka and the only cure for cirrhosis constitutes liver transplant. Nonalcoholic fatty liver disease (NAFLD) which is the hepatic component of the metabolic syndrome is the main aetiology of cirrhosis in patients presenting for liver transplant at CNCLD. Enhanced recovery after surgery (ERAS) is a concept originally adopted in colorectal surgery, and is a multimodal-multidisciplinary approach to perioperative care aiming to reduce perioperative surgical stress response and improve short-term outcome. Targeting improved outcome, components of ERAS have been incorporated in the perioperative care of liver transplant at the Colombo North Center for Liver Disease since 2016. Sri Lanka needs to define its own enhanced recovery after liver transplant (ERALT) protocols based on local data and audit performance.
C1 [Gunetilleke, Bhagya] Univ Kelaniya, Div Anaesthesia,Crit Care & Pain Management, Dept Surg, Kelaniya, Sri Lanka.
   [Gunetilleke, Bhagya] Univ Kelaniya, Fac Med, Colombo North Ctr Liver Dis, Kelaniya, Sri Lanka.
C3 University Kelaniya; University Kelaniya
RP Gunetilleke, B (corresponding author), Univ Kelaniya, Div Anaesthesia,Crit Care & Pain Management, Dept Surg, Kelaniya, Sri Lanka.; Gunetilleke, B (corresponding author), Univ Kelaniya, Fac Med, Colombo North Ctr Liver Dis, Kelaniya, Sri Lanka.
EM bhagya.gun@kln.ac.lk
OI Gunatilleke, Bhagya/0000-0002-7019-8222
CR ALDRETE JA, 1969, ANESTH ANAL CURR RES, V48, P802
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NR 29
TC 0
Z9 0
U1 0
U2 1
PU COLL ANAESTHESIOLOGISTS SRI LANKA
PI COLOMBO
PA 6 WIJERAMA MAWATHA, COLOMBO, 7, SRI LANKA
SN 1391-8834
EI 2279-1965
J9 SRI LANKAN J ANAESTH
JI Sri Lankan J. Anaesthesiol.
PY 2023
VL 31
IS 1
BP 4
EP 9
DI 10.4038/slja.31i1.9209
PG 6
WC Anesthesiology
WE Emerging Sources Citation Index (ESCI)
SC Anesthesiology
GA G0ZT2
UT WOS:000986548700002
DA 2025-06-11
ER

PT J
AU Wang, DY
   Xu, XQ
   Zhao, MJ
   Wang, X
AF Wang, Dayang
   Xu, Xiaoqing
   Zhao, Mingjing
   Wang, Xian
TI Accelerated miniature swine models of advanced atherosclerosis: A review
   based on morphology
SO CARDIOVASCULAR PATHOLOGY
LA English
DT Article
DE Miniature Swine; Atherosclerosis Models; Morphological Features;
   Familial Hypercholesterolemia; Balloon Injury; Intramural Injection
ID CORONARY-ARTERY-DISEASE; INDUCED OXIDATIVE STRESS; VASCULAR-LESIONS;
   APOLIPOPROTEIN-E; PORCINE MODEL; FAMILIAL HYPERCHOLESTEROLEMIA;
   INTRAVASCULAR ULTRASOUND; METABOLIC SYNDROME; HIGH-FAT; CHOLESTEROL
AB In order to accelerate development of atherosclerosis(AS) in miniature swine models, varieties of strategies and methods have been explored. In addition to traditional methods such as high cholesterol feeding and balloon injury, new methods such as familial hypercholesterolemia induced by gene editing and intramural injection have been applied in recent years. Although it has been claimed that these methods have successfully aggravated lesion areas and stenosis, lesion features induced by different strategies have shown heterogeneity in morphology. In addition, time consumption, high cost, and unavailability are problems that restrict application of these AS models. Here, we summarize strategies and methods to accelerate AS models and further analyze their values, advantages, and shortcomings. (C) 2020 The Author(s). Published by Elsevier Inc.
C1 [Wang, Dayang] Beijing Univ Chinese Med, Cardiovasc Dept, Dongzhimen Hosp, Beijing, Peoples R China.
   [Xu, Xiaoqing] Beijing Univ Chinese Med, Dept Neurol 3, Dongzhimen Hosp, Beijing, Peoples R China.
   [Zhao, Mingjing] Beijing Univ Chinese Med, Key Lab Chinese Internal Med, Minist Educ, Beijing, Peoples R China.
   [Zhao, Mingjing] Beijing Univ Chinese Med, Dongzhimen Hosp, Beijing, Peoples R China.
   [Wang, Xian] Beijing Univ Chinese Med, Cardiovasc Inst, Dongzhimen Hosp, Beijing, Peoples R China.
C3 Beijing University of Chinese Medicine; Beijing University of Chinese
   Medicine; Beijing University of Chinese Medicine; Ministry of Education
   - China; Beijing University of Chinese Medicine; Beijing University of
   Chinese Medicine
RP Zhao, MJ; Wang, X (corresponding author), 5 Haiyuncang, Beijing, Peoples R China.
EM wdy337@163.com; xxqxxq92@163.com; mjgx2004@163.com; wx650515@163.com
RI Wang, Dayang/HKM-7957-2023
OI Xu, Xiaoqing/0000-0002-8099-2286; Wang, Dayang/0000-0002-6680-5130
FU National Natural Science Foundation of China [81774058]
FX This work was supported by the National Natural Science Foundation of
   China (grant number 81774058).
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NR 75
TC 14
Z9 16
U1 0
U2 6
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1054-8807
EI 1879-1336
J9 CARDIOVASC PATHOL
JI Cardiovasc. Pathol.
PD NOV-DEC
PY 2020
VL 49
AR 107241
DI 10.1016/j.carpath.2020.107241
PG 11
WC Cardiac & Cardiovascular Systems; Pathology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Pathology
GA NW4JX
UT WOS:000574975800007
PM 32554057
OA hybrid
DA 2025-06-11
ER

PT J
AU Rana, S
   Mishra, M
   Yadav, D
   Subramani, SK
   Katare, C
   Prasad, GBKS
AF Rana, Seema
   Mishra, Meerambika
   Yadav, Dhananjay
   Subramani, Senthil Kumar
   Katare, Charu
   Prasad, G. B. K. S.
TI Medicinal uses of honey: a review on its benefits to human health
SO PROGRESS IN NUTRITION
LA English
DT Review
DE honey; anti-diabetic; anti-hyperlipidemic; antioxidant; wound healing;
   antimicrobial
ID TYPE-2 DIABETES-MELLITUS; CHRONIC KIDNEY-DISEASE; SUGAR-FREE DIET;
   IN-VITRO; NATURAL HONEY; PHYSICOCHEMICAL CHARACTERISTICS; ANTIOXIDANT
   CAPACITY; POLYPHENOL CONTENT; METABOLIC SYNDROME; OXIDATIVE STRESS
AB Honey often referred to as 'the drink of the gods', is naturally sweet and a substantially rich source of carbohydrates, amino acids and antioxidants. In spite of being rich in carbohydrates, honey has a low glycemic index and therefore effectively used as a dietary compliance by diabetics. The fructose content of honey has hepatoprotective capability, while the antioxidants present in it provide effective protection against oxidative damage. The therapeutic attribute of honey makes it the food of choice even in infants and diabetics. Honey is endowed with antioxidant, immune modulating, and wound healing, anti-inflammatory, therapeutic, nutritional, antimicrobial and antidiabetic qualities. The present review aims at discussing these capabilities of honey with special reference to its antidiabetic benefits under one dome.
C1 [Rana, Seema; Katare, Charu] Govt KRG PG Autonomous Coll, Dept Food & Nutr, Gwalior, India.
   [Mishra, Meerambika] Sambalpur Univ, Sch Life Sci, Jyoti Vihar, Odisha, India.
   [Yadav, Dhananjay] Yeungnam Univ, Dept Med Biotechnol, Gyongsan 712749, South Korea.
   [Subramani, Senthil Kumar; Prasad, G. B. K. S.] Jiwaji Univ, Sch Biochem, Gwalior 474011, India.
C3 Sambalpur University; Yeungnam University; Jiwaji University Gwalior
RP Yadav, D (corresponding author), Yeungnam Univ, Dept Med Biotechnol, Gyongsan 712749, South Korea.; Prasad, GBKS (corresponding author), Jiwaji Univ, Sch Biochem, Gwalior 474011, India.
EM dhanyadav16481@gmail.com; gbksprasad@gmail.com
RI Mishra, Meerambika/AAH-6380-2020; KUMAR, SUNIL/ABG-7529-2022; Yadav,
   Dhananjay/AAZ-9435-2021
OI subramani, senthilkumar/0000-0001-5603-3002; Mishra,
   Meerambika/0000-0001-7124-7367
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NR 76
TC 20
Z9 21
U1 1
U2 47
PU MATTIOLI 1885
PI FIDENZA
PA VIA DELLA LODESANA 649-SX, FIDENZA, 43046 PR, ITALY
SN 1129-8723
J9 PROG NUTR
JI Prog. Nutr.
PD JUL
PY 2018
VL 20
SU 1
BP 5
EP 14
DI 10.23751/pn.v20i1-S.6394
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA GP7MN
UT WOS:000441085500001
DA 2025-06-11
ER

PT J
AU Nguyen, DV
   Linderholm, A
   Haczku, A
   Kenyon, N
AF Dan-Vinh Nguyen
   Linderholm, Angela
   Haczku, Angela
   Kenyon, Nicholas
TI Glucagon-like peptide 1: A potential anti-inflammatory pathway in
   obesity-related asthma
SO PHARMACOLOGY & THERAPEUTICS
LA English
DT Review
DE Glucagon-like peptide 1; Advanced glycation end products; Arginine;
   Obesity; Asthma
ID GLYCATION END-PRODUCTS; AIRWAY INFLAMMATION; METABOLIC SYNDROME;
   ASYMMETRIC DIMETHYLARGININE; DIPEPTIDYL PEPTIDASE-4; RECEPTOR; GLP-1;
   SECRETION; CELLS; RAGE
AB Alterations in arginine metabolism and accelerated formation of advanced glycation end-products (AGEs), crucial mechanisms in obesity-related asthma, can be modulated by glucagon-like peptide 1 (GLP-1) L-arginine dysregulation in obesity promotes inflammation and bronchoconstriction. Prolonged hyperglycemia, dyslipidemia, and oxidative stress leads to production of AGEs, that bind to their receptor (RAGE) further potentiating inflammation. By binding to its widely distributed receptor, GLP-1 blunts the effects of RAGE activation and arginine dysregulation. The GLP-1 pathway, while comprehensively studied in the endocrine and cardiovascular literature, is under-recognized in pulmonary research. Insights into GLP-1 and the lung may lead to novel treatments for obesity-related asthma. Published by Elsevier Inc.
C1 [Dan-Vinh Nguyen; Linderholm, Angela; Haczku, Angela; Kenyon, Nicholas] Univ Calif Davis, Vet Affairs Northern Calif Healthcare Syst, Davis, CA 95616 USA.
C3 University of California System; University of California Davis
RP Nguyen, DV (corresponding author), Univ Calif Davis, Vet Affairs Northern Calif Healthcare Syst, Davis, CA 95616 USA.
EM dvpnguyen@ucdavis.edu
RI Haczku, Angela/A-8486-2013
OI Haczku, Angela/0000-0002-1301-4941
FU Veterans Affairs Northern California Healthcare System; United States
   Department of Health and Human Services, National Institutes of
   Health/National Heart, Lung, and Blood Institute [T32 HL07013,
   4R01HL105573-05]
FX This research was funded by the United States Department of Health and
   Human Services, National Institutes of Health/National Heart, Lung, and
   Blood Institute Grants T32 HL07013 and 4R01HL105573-05, and the Veterans
   Affairs Northern California Healthcare System.
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NR 54
TC 40
Z9 42
U1 0
U2 19
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0163-7258
J9 PHARMACOL THERAPEUT
JI Pharmacol. Ther.
PD DEC
PY 2017
VL 180
BP 139
EP 143
DI 10.1016/j.pharmthera.2017.06.012
PG 5
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA FN9WW
UT WOS:000416394600011
PM 28648831
OA Green Submitted, Green Accepted
DA 2025-06-11
ER

PT J
AU Fernández-Alfonso, MS
   Gil-Ortega, M
   García-Prieto, CF
   Aranguez, I
   Ruiz-Gayo, M
   Somoza, B
AF Fernandez-Alfonso, Maria S.
   Gil-Ortega, Marta
   Garcia-Prieto, Concha F.
   Aranguez, Isabel
   Ruiz-Gayo, Mariano
   Somoza, Beatriz
TI Mechanisms of Perivascular Adipose Tissue Dysfunction in Obesity
SO INTERNATIONAL JOURNAL OF ENDOCRINOLOGY
LA English
DT Review
ID NITRIC-OXIDE; ENDOTHELIAL DYSFUNCTION; VASCULAR FUNCTION; OXIDATIVE
   STRESS; METABOLIC SYNDROME; HYDROGEN-PEROXIDE; LEPTIN; ADIPONECTIN;
   MICE; HYPOXIA
AB Most blood vessels are surrounded by adipose tissue. Similarly to the adventitia, perivascular adipose tissue (PVAT) was considered only as a passive structural support for the vasculature, and it was routinely removed for isolated blood vessel studies. In 1991, Soltis and Cassis demonstrated for the first time that PVAT reduced contractions to noradrenaline in rat aorta. Since then, an important number of adipocyte-derived factors with physiological and pathophysiological paracrine vasoactive effects have been identified. PVAT undergoes structural and functional changes in obesity. During early diet-induced obesity, an adaptative overproduction of vasodilator factors occurs in PVAT, probably aimed at protecting vascular function. However, in established obesity, PVAT loses its anticontractile properties by an increase of contractile, oxidative, and inflammatory factors, leading to endothelial dysfunction and vascular disease. The aim of this review is to focus on PVAT dysfunction mechanisms in obesity.
C1 [Fernandez-Alfonso, Maria S.; Aranguez, Isabel] Univ Complutense, Inst Pluridisciplinar, E-28040 Madrid, Spain.
   [Fernandez-Alfonso, Maria S.; Aranguez, Isabel] Univ Complutense, Fac Farm, E-28040 Madrid, Spain.
   [Gil-Ortega, Marta; Garcia-Prieto, Concha F.; Ruiz-Gayo, Mariano; Somoza, Beatriz] Univ CEU San Pablo, Fac Farm, Dept Ciencias Farmaceut & Salud, Madrid 28660, Spain.
C3 Complutense University of Madrid; Complutense University of Madrid; San
   Pablo CEU University
RP Fernández-Alfonso, MS (corresponding author), Univ Complutense, Inst Pluridisciplinar, Juan 23 1, E-28040 Madrid, Spain.
EM marisolf@farm.ucm.es
RI Ruiz-Gayo, Mariano/H-3720-2015; Somoza, Beatriz/M-1260-2017; Gil-Ortega,
   Marta/M-8742-2015; Fernandez-Alfonso, Maria S./F-5066-2016
OI Gil-Ortega, Marta/0000-0002-6366-8214; Fernandez-Alfonso, Maria
   S./0000-0002-9110-8070
FU Ministerio de Ciencia e Investigacion [SAF 2009-09714, SAF2011-25303];
   Grupos UCM [GR-921641]; Fundacion Universitaria San Pablo-CEU; Fundacion
   Mutua Madrilena; SESCAMET
FX This work was supported by Grants from Ministerio de Ciencia e
   Investigacion (SAF 2009-09714, SAF2011-25303), Grupos UCM (GR-921641),
   Fundacion Universitaria San Pablo-CEU, Fundacion Mutua Madrilena, and
   SESCAMET. The funders had no role in study design, data collection and
   analysis, decision to publish, or preparation of the paper.
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NR 68
TC 59
Z9 60
U1 0
U2 6
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1687-8337
EI 1687-8345
J9 INT J ENDOCRINOL
JI Int. J. Endocrinol.
PY 2013
VL 2013
AR 402053
DI 10.1155/2013/402053
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 252VG
UT WOS:000327038200001
OA Green Submitted, gold, Green Published
DA 2025-06-11
ER

PT J
AU Jansen, PLM
AF Jansen, PLM
TI Non alcoholic steatohepatitis - Introduction
SO EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
LA English
DT Review
DE non-alcoholic fatty liver disease; non-alcoholic steatohepatitis;
   obesity; oxidative stress; insulin resistance; peroxisome
   proliferator-activated receptor; sterol regulatory element binding
   protein; adiponectin; thiazolidinediones
ID NONALCOHOLIC FATTY LIVER; PROLIFERATOR-ACTIVATED-RECEPTOR; HEPATIC
   CYTOCHROME-P450 2E1; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   HEPATOCELLULAR-CARCINOMA; CHENODEOXYCHOLIC ACID; CRYPTOGENIC CIRRHOSIS;
   VITAMIN-E; MITOCHONDRIAL DYSFUNCTION
AB Non-alcoholic steatohepatitis (NASH) is an underdiagnosed liver disease characterized by steatosis, necroinflammation and fibrosis. This disease may eventually develop into cirrhosis and hepatocellular carcinoma. NASH is highly prevalent among obese individuals and among patients with diabetes mellitus type 2. Non-alcoholic fatty liver (NAFL), a precursor of NASH, is the main cause of elevated serum liver enzymes among the general population. In NASH the liver is programmed to lipogenesis rather than to glycogenesis and herein insulin-resistance plays a major role. Gradual weight loss, physical exercise and drugs that improve insulin sensitivity are potential therapies. (C) 2004 Lippincott Williams Wilkins.
C1 Univ Amsterdam, Acad Med Ctr, Dept Gastroenterol & Hepatol, NL-1105 AZ Amsterdam, Netherlands.
C3 University of Amsterdam; Academic Medical Center Amsterdam
RP Univ Amsterdam, Acad Med Ctr, Dept Gastroenterol & Hepatol, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands.
EM pljansen@amc.uva.nl
RI Jansen, Peter/I-4509-2013
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NR 87
TC 46
Z9 56
U1 1
U2 16
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0954-691X
EI 1473-5687
J9 EUR J GASTROEN HEPAT
JI Eur. J. Gastroenterol. Hepatol.
PD NOV
PY 2004
VL 16
IS 11
BP 1079
EP 1085
DI 10.1097/00042737-200411000-00001
PG 7
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 871TB
UT WOS:000225155300001
PM 15489564
DA 2025-06-11
ER

PT J
AU Azcona-Sanjulian, MC
AF Cristina Azcona-Sanjulian, Maria
TI Telomere Length and Pediatric Obesity: A Review
SO GENES
LA English
DT Review
DE obesity; overweight; telomere length; children; adolescents
ID SHORTER TELOMERES; PHYSICAL-ACTIVITY; ASSOCIATION; HERITABILITY;
   INFLAMMATION; DYNAMICS; STRESS
AB Obesity is a chronic disease, which needs to be early detected early and treated in order prevent its complications. Changes in telomere length (TL) have been associated with obesity and its complications, such as diabetes mellitus and metabolic syndrome. Therefore, we conducted a systematic review to summarize results of studies that have measured TL in children and adolescents with obesity. Fourteen studies aiming to assess TL in pediatric patients with either obesity or who were overweight were included in this review. In conclusion, obesity and adiposity parameters are negatively associated with TL. Shorter telomeres are observed in children with obesity compared with their lean counterparts. Factors involved in obesity etiology, such as diet and physical activity, may contribute to maintenance of TL integrity. In the long term, TL change could be used as a biomarker to predict response to obesity treatment.
C1 [Cristina Azcona-Sanjulian, Maria] Clin Univ Navarra, Dept Paediat, Paediat Endocrinol Unit, Ave Pio XII 36, Pamplona 31008, Spain.
   [Cristina Azcona-Sanjulian, Maria] Inst Res Navarra, Pamplona 31008, Spain.
C3 University of Navarra
RP Azcona-Sanjulian, MC (corresponding author), Clin Univ Navarra, Dept Paediat, Paediat Endocrinol Unit, Ave Pio XII 36, Pamplona 31008, Spain.; Azcona-Sanjulian, MC (corresponding author), Inst Res Navarra, Pamplona 31008, Spain.
EM cazcona@unav.es
RI Azcona, Cristina/A-1160-2015
OI Azcona, Cristina/0000-0001-5534-8758
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NR 45
TC 9
Z9 9
U1 0
U2 7
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2073-4425
J9 GENES-BASEL
JI Genes
PD JUN
PY 2021
VL 12
IS 6
AR 946
DI 10.3390/genes12060946
PG 9
WC Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Genetics & Heredity
GA SZ1AX
UT WOS:000666308300001
PM 34205609
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Spruijt-Metz, D
   O'Reilly, GA
   Cook, L
   Page, KA
   Quinn, C
AF Spruijt-Metz, Donna
   O'Reilly, Gillian A.
   Cook, Lauren
   Page, Kathleen A.
   Quinn, Charlene
TI Behavioral Contributions to the Pathogenesis of Type 2 Diabetes
SO CURRENT DIABETES REPORTS
LA English
DT Article
DE Type 2 diabetes; Behavior; Pathogenesis Technology
ID SUGAR-SWEETENED BEVERAGES; DISEASE RISK-FACTORS; PHYSICAL-ACTIVITY;
   SLEEP DURATION; DIETARY FIBER; METABOLIC SYNDROME; GLUCOSE-TOLERANCE;
   LIFE-STYLE; VEGETABLE INTAKE; COOKING INTERVENTION
AB Behavioral contributions to the pathogenesis of prediabetes and Type 2 diabetes (T2D) include lifestyle behaviors including dietary intake, exercise, sedentariness, sleep, and stress. The purpose of this paper is to review evidence for the metabolic pathways by which the behavior is linked to T2D. Evidence for interventions, which change each of the lifestyle behaviors, is discussed. The article will close with a brief discussion on how new technologies may provide opportunities to better understand relationships between moment-to-moment fluctuations in behaviors and diabetes pathogenesis, as well as provide opportunities to personalize and adapt interventions to achieve successful behavior change and maintenance of that change. Especially promising are new technologies, which assist in tracking lifestyle behaviors along with clinical and metabolic outcomes.
C1 [Spruijt-Metz, Donna] Univ So Calif, Ctr Econ & Social Res, Playa Vista, CA 90094 USA.
   [Spruijt-Metz, Donna; O'Reilly, Gillian A.; Cook, Lauren] Univ So Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90033 USA.
   [Page, Kathleen A.] Univ So Calif, Keck Sch Med, Dept Internal Med, Div Endocrinol, Los Angeles, CA 90033 USA.
   [Quinn, Charlene] Univ Maryland, Sch Med, Dept Epidemiol & Publ Hlth, Baltimore, MD 21201 USA.
C3 University of Southern California; University of Southern California;
   University of Southern California; University System of Maryland;
   University of Maryland Baltimore
RP Spruijt-Metz, D (corresponding author), Univ So Calif, Ctr Econ & Social Res, 12015 Waterfront Dr, Playa Vista, CA 90094 USA.
EM dmetz@usc.edu
RI Quinn, Charlene/B-9321-2009
FU National Cancer Institute of the National Institutes of Health
   [T32CA009492]; National Cancer Institute of the National Center for
   Research Resources; Division of Program Coordination, Planning, and
   Strategic Initiatives of the National Institutes of Health [R25RR032159]
FX This work was supported by the National Cancer Institute of the National
   Institutes of Health award number T32CA009492 and National Center for
   Research Resources and the Division of Program Coordination, Planning,
   and Strategic Initiatives of the National Institutes of Health through
   Grant Number R25RR032159. This work was also supported by a grant given
   to USC Keck School of Medicine.
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NR 127
TC 24
Z9 35
U1 0
U2 43
PU CURRENT MEDICINE GROUP
PI PHILADELPHIA
PA 400 MARKET STREET, STE 700, PHILADELPHIA, PA 19106 USA
SN 1534-4827
EI 1539-0829
J9 CURR DIABETES REP
JI Curr. Diabetes Rep.
PD APR
PY 2014
VL 14
IS 4
AR 475
DI 10.1007/s11892-014-0475-3
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism
GA AD4FF
UT WOS:000333202500003
PM 24604714
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Enerbäck, C
AF Enerback, Charlotta
TI Soluble biomarkers in psoriasis
SO EUROPEAN JOURNAL OF DERMATOLOGY
LA English
DT Review
DE biomarker; cytokine; growth factor; psoriasis
ID NECROSIS-FACTOR-ALPHA; C-REACTIVE PROTEIN; INTERLEUKIN-1 RECEPTOR
   ANTAGONIST; SUCTION BLISTER FLUIDS; GROWTH-FACTOR; SERUM-LEVELS;
   DISEASE-ACTIVITY; TNF-ALPHA; MYOCARDIAL-INFARCTION;
   PLASMA-CONCENTRATIONS
AB Psoriasis is a common, chronic, recurrent skin disorder, characterized by keratinocyte proliferation, T-cell activation and angiogenesis. The results of various clinical and experimental studies indicate that psoriasis is a complex, multifactorial disease with a genetic predisposition. During the past few years, many studies related to psoriasis biomarkers have been conducted. Biomarkers can relate to diagnosis, pathogenesis, prognosis, or therapeutic response. They could provide insight into disease susceptibility and natural history. The identification of biomarkers related to co-morbidities in psoriasis, such as arthritis, cardiovascular disease and the metabolic syndrome, has attracted special interest. This review presents current knowledge of soluble biomarkers in psoriasis, including cytokines, chemokines, pro-angiogenic mediators, growth factors, antimicrobial proteins, neuropeptides and markers of oxidative stress.
C1 Linkoping Univ, Div Cell Biol & Dermatol, Dept Clin & Expt Med, SE-58185 Linkoping, Sweden.
C3 Linkoping University
RP Enerbäck, C (corresponding author), Linkoping Univ, Div Cell Biol & Dermatol, Dept Clin & Expt Med, SE-58185 Linkoping, Sweden.
EM charlotta.enerback@liu.se
FU Ingrid Asp Foundation
FX Financial support: Ingrid Asp Foundation. Conflicts of interest: none.
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NR 87
TC 16
Z9 16
U1 0
U2 9
PU JOHN LIBBEY EUROTEXT LTD
PI MONTROUGE
PA 127 AVE DE LA REPUBLIQUE, 92120 MONTROUGE, FRANCE
SN 1167-1122
EI 1952-4013
J9 EUR J DERMATOL
JI Eur. J. Dermatol.
PD NOV-DEC
PY 2011
VL 21
IS 6
BP 844
EP 850
DI 10.1684/ejd.2011.1482
PG 7
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 894II
UT WOS:000300420000001
PM 21856557
DA 2025-06-11
ER

PT J
AU Kühnlein, RP
AF Kuehnlein, Ronald P.
TI Drosophila as a lipotoxicity model organism - more than a
   promise?
SO BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
LA English
DT Review
DE Drosophila; Lipotoxicity; Model organism; Energy homeostasis;
   Lipometabolism
ID ENDOPLASMIC-RETICULUM STRESS; ADIPOSE TRIGLYCERIDE LIPASE; ACTIVATED
   PROTEIN-KINASE; QUANTITATIVE TRAIT LOCI; LIPID STORAGE DISEASE;
   BETA-CELL APOPTOSIS; EXTENDS LIFE-SPAN; ADULT DROSOPHILA;
   FAT-METABOLISM; HEART FUNCTION
AB Looking back over the century long research career of the fruit fly, Drosophila melanogaster has frequently been in the scientific spotlight with respect to fundamental discoveries in biology. The last decade witnessed the increasing importance of the fly as a human disease model but studies on energy homeostasis and lipometabolism remain in their infancy. This perspective, addressing readers largely unfamiliar with the Drosophila model system, aims to highlight the starting points for which the fly could be employed to gain a deeper understanding of lipotoxicity and possibly contribute to strategies for the identification of novel drug targets relevant to type 2 diabetes mellitus and the metabolic syndrome. (C) 2009 Elsevier B.V. All rights reserved.
C1 Max Planck Inst Biophys Chem, Dept Mol & Dev Biol, D-37077 Gottingen, Germany.
C3 Max Planck Society
RP Kühnlein, RP (corresponding author), Max Planck Inst Biophys Chem, Dept Mol & Dev Biol, Fassberg 11, D-37077 Gottingen, Germany.
EM rkuehnl@gwdg.de
OI Kuhnlein, Ronald P./0000-0003-1448-4117
FU Max Planck Society
FX I apologise for the omission of any relevant publications that have not
   been included either due to the very specific focus of this review or to
   space constraints. The author is grateful to Susan Smith for careful
   reading of the manuscript. This work was supported by the Max Planck
   Society.
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NR 175
TC 19
Z9 24
U1 0
U2 17
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1388-1981
EI 0006-3002
J9 BBA-MOL CELL BIOL L
JI Biochim. Biophys. Acta Mol. Cell Biol. Lipids
PD MAR
PY 2010
VL 1801
IS 3
SI SI
BP 215
EP 221
DI 10.1016/j.bbalip.2009.09.006
PG 7
WC Biochemistry & Molecular Biology; Biophysics; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Cell Biology
GA 568YT
UT WOS:000275563300003
PM 19781664
OA Green Published
DA 2025-06-11
ER

PT J
AU Köteles, ÉM
   Rafael, B
   Korom, A
   Vágvölgyi, A
   Abrahám, JE
   Domján, A
   Szucs, M
   Nemes, A
   Barnai, M
   Lengyel, C
   Kósa, I
AF Koteles, Eva Mathene
   Rafael, Beatrix
   Korom, Andrea
   Vagvolgyi, Anna
   Abraham, Judit Erzsebet
   Domjan, Andrea
   Szucs, Monika
   Nemes, Attila
   Barnai, Maria
   Lengyel, Csaba
   Kosa, Istvan
TI Physiological and psychological effects of a 12-week home-based
   telemonitored training in metabolic syndrome
SO FRONTIERS IN CARDIOVASCULAR MEDICINE
LA English
DT Article
DE telerehabilitation; telemonitoring; metabolic syndrome; home-based;
   exercise training; psychological factors
ID DENSITY-LIPOPROTEIN CHOLESTEROL; LIFE-STYLE INTERVENTION; VITAL
   EXHAUSTION; CORONARY EVENTS; HEART-DISEASE; CARDIAC REHABILITATION;
   CARDIOVASCULAR-DISEASE; RISK-FACTORS; STATEMENT; PRAVASTATIN
AB BackgroundMetabolic Syndrome (MetS) increases the risk of cardiovascular diseases (CVD) and affects around one fourth of the population worldwide. In the prevention and treatment regular exercise trainings are inevitable. Providing personal supervision in out/inpatient care settings for such a large target population challenges the healthcare systems, but using telemonitoring of the home-performed trainings could be a promising and widely available option. ObjectivesThe aim of this study was to evaluate the physiological and psychological effects of a 12-week home-based physical training program, telemonitored by widely available fitness devices on parameters of MetS patients. MethodsA total of 55 MetS patients (mean age 49.19 +/- 7.93 years) were involved in the study. They were asked to perform 3-5 sessions of exercise activity (min. 150 min) each week for 12 weeks. Trainings were monitored off-line by heart rate sensors, a fitness application and a cloud-based data transfer system. Physiotherapists supervised, coached, and feedback the trainings through an online coach system. We investigated different anthropometric parameters, maximum exercise and functional capacity levels, laboratory parameters, the level of depression, insomnia, vital exhaustion, and wellbeing as well. ResultsThe average weekly training time was 152.0 +/- 116.2 min. Out of the 55 participants who completed the program, 22 patients (40%) performed the recommended 150 min or more weekly. Patients showed statistically significant changes in: all the measured waist and hip circumferences; 6-min walk distance (6MWD; from 539.69 +/- 78.62 to 569.72 +/- 79.96 m, p < 0.001); maximal exercise capacity (11.02 +/- 2.6 to 12.14 +/- 2 MET, p < 0.001), stress-electrocardiogram duration time (13.74 +/- 3.29 to 15.66 +/- 2.64 min, p < 0.001); body weight (98.72 +/- 21.7 to 97.45 +/- 21.76 kg, p = 0.004); high-density lipoprotein cholesterol (n = 45, 1.28 +/- 0.31 to 1.68 +/- 0.36 mmol/L, p < 0.001); fasting plasma glucose (FPG; n = 47, 6.16 +/- 1.26 to 5.44 +/- 1.31 mmol/L, p = 0.001); glycated hemoglobin A1c (HbA1c; n = 41, 6.22 +/- 0.68 to 5.87 +/- 0.78%, p = 0.01). Out of the 55 patients who finished the program 38 patients (70%) completed all the psychological questionnaires. We found statistically significant decrease of the overall scores of the Maastricht Vital Exhaustion Questionnaire, from 3.37 +/- 2.97 points to 2.63 +/- 2.70 points (p < 0.05) and a significant increase of the overall scores of the WHO Wellbeing Scale from 9.92 +/- 2.59 points to 10.61 +/- 2.76 points (p < 0.05). We have not found any statistically significant changes in the scores of the Beck Depression Inventory and the Athens Insomnia Scale. ConclusionA 12-week home-based telemonitored training supported by an affordable, commonly available device system produces positive, statistically significant changes in many core components in MetS patients. Telemonitoring is a cheap method for coaching and feeding back the home-based interventions.
C1 [Koteles, Eva Mathene; Korom, Andrea; Domjan, Andrea; Barnai, Maria] Univ Szeged, Fac Hlth Sci & Social Studies, Dept Physiotherapy, Szeged, Hungary.
   [Rafael, Beatrix; Abraham, Judit Erzsebet; Kosa, Istvan] Univ Szeged, Albert Szent Gyorgyi Med Sch, Dept Med Prevent, Szeged, Hungary.
   [Vagvolgyi, Anna; Nemes, Attila; Lengyel, Csaba; Kosa, Istvan] Univ Szeged, Albert Szent Gyorgyi Med Sch, Dept Med, Szeged, Hungary.
   [Szucs, Monika] Univ Szeged, Albert Szent Gyorgyi Med Sch, Dept Med Phys & Informat, Szeged, Hungary.
C3 Szeged University; Szeged University; Szeged University; Szeged
   University
RP Nemes, A (corresponding author), Univ Szeged, Albert Szent Gyorgyi Med Sch, Dept Med, Szeged, Hungary.
EM nemes.attila@med.u-szeged.hu
RI Szucs, Monika/I-5292-2018; Andrea, Domján/KEJ-4804-2024; Kósa,
   István/AHE-4081-2022
OI Szucs, Monika/0000-0002-8791-9452; Mathene Koteles,
   Eva/0000-0002-9728-5182
FU European Union - European Social Fund [EFOP-3.6.1-16-2016-00008,
   EFOP-3.6.3-VEKOP-16-2017-00009]
FX Funding This project has been supported by the European Union,
   co-financed by the European Social Fund EFOP-3.6.1-16-2016-00008 and
   EFOP-3.6.3-VEKOP-16-2017-00009.
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NR 54
TC 3
Z9 3
U1 1
U2 5
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2297-055X
J9 FRONT CARDIOVASC MED
JI Front. Cardiovasc. Med.
PD JAN 10
PY 2023
VL 9
AR 1075361
DI 10.3389/fcvm.2022.1075361
PG 14
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 8C6JR
UT WOS:000917712800001
PM 36704473
OA Green Published, gold, Green Accepted
DA 2025-06-11
ER

PT J
AU Hopealaakso, TK
   Thomas, JT
   Pätilä, T
   Penttala, M
   Sakellari, D
   Grigoriadis, A
   Gupta, S
   Sorsa, T
   Räisänen, IT
AF Hopealaakso, Taija Kristiina
   Thomas, Julie Toby
   Patila, Tommi
   Penttala, Miika
   Sakellari, Dimitra
   Grigoriadis, Andreas
   Gupta, Shipra
   Sorsa, Timo
   Raisanen, Ismo T.
TI Periodontitis, Metabolic Syndrome and Diabetes: Identifying Patients at
   Risk for Three Common Diseases Using the aMMP-8 Rapid Test at the
   Dentist's Office
SO DIAGNOSTICS
LA English
DT Review
DE periodontitis; active-matrix metalloproteinase-8; aMMP-8; diabetes
   mellitus; biomarker
ID GINGIVAL CREVICULAR FLUID; NEUTROPHIL COLLAGENASE ACTIVITY; PERI-IMPLANT
   DISEASES; MATRIX METALLOPROTEINASE-8; POTENTIAL RISK; SMOKING; MELLITUS;
   BIOMARKERS; SALIVA; CLASSIFICATION
AB Background/Objectives: This narrative review paper highlights the multifaceted influence of dysbiotic biofilm, genetic background, host response, and environmental factors on periodontitis. It explores the roles of type I and II diabetes mellitus, gestational diabetes, and metabolic syndrome in the progression of periodontitis, drawing insights from various empirical studies and theoretical perspectives. Methods: Relevant articles were sourced using keywords in databases like PubMed/Medline, Science Direct, Scopus, and Google Scholar. Additionally, this review examines the relationship between aMMP-8 levels and increased glycemic states, as well as varying degrees of periodontitis severity. Results: The biomarker active-matrix metalloproteinase-8 (aMMP-8), produced by polymorphonuclear leukocytes (PMN), is highlighted as a reliable indicator of ongoing connective tissue degradation. Dysfunctions in PMN activity, accumulation of advanced glycation end products (AGE), and oxidative stress aggravate the periodontal inflammatory response and complications of diabetes. Traditional diagnostics of periodontitis do not provide sufficient information about the current or future disease initiation or activity of periodontitis. Conclusions: The implications of this review point to the need for monitoring periodontal health by utilizing innovative strategies like aMMP-8 point-of-care testing, using oral rinse for screening and treatment monitoring, and harnessing the potential of supportive treatments like low-dose doxycycline and light-activated mouth rinses for restoring periodontal health. Its expression in oral fluids is a promising diagnostic tool to differentiate periodontitis from gingivitis and healthy periodontium, especially when associated with systemic diseases, fostering greater collaboration among healthcare professionals.
C1 [Hopealaakso, Taija Kristiina; Thomas, Julie Toby; Penttala, Miika; Sorsa, Timo; Raisanen, Ismo T.] Univ Helsinki, Head & Neck Ctr, Dept Oral & Maxillofacial Dis, Helsinki 00290, Finland.
   [Hopealaakso, Taija Kristiina; Thomas, Julie Toby; Patila, Tommi; Penttala, Miika; Sorsa, Timo; Raisanen, Ismo T.] Helsinki Univ Hosp, Helsinki 00290, Finland.
   [Patila, Tommi] Univ Helsinki, New Childrens Hosp, Dept Pediat Surg, Helsinki 00290, Finland.
   [Sakellari, Dimitra; Grigoriadis, Andreas] Aristotle Univ Thessaloniki, Fac Hlth Sci, Dent Sch, Dept Prevent Dent Periodontol & Implant Biol, Thessaloniki 54124, Greece.
   [Grigoriadis, Andreas] 424 Gen Mil Training Hosp, Dent Sect, Thessaloniki 56429, Greece.
   [Gupta, Shipra] Post Grad Inst Med Educ & Res PGIMER, Oral Hlth Sci Ctr, Chandigarh 160012, India.
   [Sorsa, Timo] Karolinska Inst, Dept Oral Dis, S-17177 Stockholm, Sweden.
C3 University of Helsinki; University of Helsinki; Helsinki University
   Central Hospital; University of Helsinki; Aristotle University of
   Thessaloniki; Post Graduate Institute of Medical Education & Research
   (PGIMER), Chandigarh; Karolinska Institutet
RP Räisänen, IT (corresponding author), Univ Helsinki, Head & Neck Ctr, Dept Oral & Maxillofacial Dis, Helsinki 00290, Finland.; Räisänen, IT (corresponding author), Helsinki Univ Hosp, Helsinki 00290, Finland.
RI Thomas, Julie/AAM-4406-2021; SAKELLARI, Dimitra/AAH-3427-2019; Pätilä,
   Tommi/IRY-9409-2023; Räisänen, Ismo/AAG-6860-2021
OI Grigoriadis, Andreas/0000-0002-5542-2230; Patila,
   Tommi/0000-0003-2219-4689
FU Helsinki and Uusimaa Hospital District (HUS), Finland; Finnish Dental
   Association Apol-lonia, Finland; Karolinska Institutet, Sweden;  [TYH
   2020337];  [TYH 2022225];  [Y2519SU010]
FX This research was funded by the Helsinki and Uusimaa Hospital District
   (HUS), Finland, grant number TYH 2020337, TYH 2022225, Y2519SU010 (TS),
   the Finnish Dental Association Apol-lonia, Finland (TS), and Karolinska
   Institutet, Sweden (TS). The funders had no role in the design of this
   study, in the collection, analyses, or interpretation of data, in the
   writing of this manuscript, or in the decision to publish the results.
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NR 83
TC 1
Z9 1
U1 1
U2 1
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2075-4418
J9 DIAGNOSTICS
JI Diagnostics
PD DEC
PY 2024
VL 14
IS 24
AR 2878
DI 10.3390/diagnostics14242878
PG 13
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA Q5F3N
UT WOS:001384932500001
PM 39767238
OA gold
DA 2025-06-11
ER

PT J
AU Giammo, A
   Sarzi-Puttini, P
   Favro, M
   De Pedrini, A
   Baj, G
AF Giammo, Alessandro
   Sarzi-Puttini, Piercarlo
   Favro, Michele
   De Pedrini, Alberto
   Baj, Germano
TI Rationale of Insulin-Sensitizing Agents in the Treatment of Functional
   Bladder Disorders
SO JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
LA English
DT Review
DE insulin resistance (IR); overactive bladder syndrome (OAB);
   inflammation; myo-inositol (MI)
ID URINARY-TRACT SYMPTOMS; FATTY LIVER-DISEASE; OVERACTIVE BLADDER;
   VITAMIN-C; METABOLIC SYNDROME; DIABETES-MELLITUS; FOLATE
   SUPPLEMENTATION; RHEUMATOID-ARTHRITIS; GLYCEMIC CONTROL; FIBROMYALGIA
AB Recently, there has been increasing interest in the complex function of insulin, not only in its familiar role as a blood glucoseregulating hormone but also as a growth factor and biological regulator. This publication reviews the literature related to insulin resistance (IR) as a causative and exacerbating element in functional urological disorders, including overactive bladder syndrome (OAB). Patients with OAB or similar disorders often present with seemingly unrelated medical issues, such as metabolic syndrome (MetS), fibromyalgia (FM), psoriatic arthritis (PsA), and polycystic ovary syndrome (PCOS). However, these conditions interact with one another and can result in complex clinical scenarios. The literature reviewed delineates a pathophysiological circuit among these disorders, which share the chronic inflammation and underlying oxidative stress caused by IR. Growing evidence from both animal model studies and randomized clinical trials indicates that certain molecules, such as myo-inositol (MI), magnesium (Mg2+), folic acid (FoA), vitamin C (Vc), ferulic acid (FA), and vitamin D (Vd), are effective in treating functional bladder disorders and other syndromes linked to IR. Their success is attributable first and foremost to their insulin-sensitizing actions and, therefore, to their antioxidant and anti-inflammatory properties. Moreover, these treatments are generally safe and well-tolerated, whether used alone or in combination with existing therapies. Therefore, administering these substances to patients with conditions in which IR is known to be a key etiologic factor holds scientific justification and represents a promising therapeutic approach with potential future applications.
C1 [Giammo, Alessandro] Citta Salute & Sci Torino, Neurourol Dept, CTO Spinal Cord Unit, I-10126 Turin, Italy.
   [Sarzi-Puttini, Piercarlo] RCCS Osped Galeazzi St Ambrogio, Rheumatol Dept, I-20161 Milan, Italy.
   [Favro, Michele] Univ Piemonte Orientale, Maggiore Carita Hosp, Div Urol, I-28100 Novara, Italy.
   [De Pedrini, Alberto] Univ Piemonte Orientale, Maggiore Carita Hosp, Dept Gynecol & Obstet, I-28100 Novara, Italy.
   [Baj, Germano] CAOM Ctr Appl Erbe Officinali & Frutti Minori, I-28100 Novara, Italy.
C3 A.O.U. Citta della Salute e della Scienza di Torino; University of
   Eastern Piedmont Amedeo Avogadro; University of Eastern Piedmont Amedeo
   Avogadro
RP Baj, G (corresponding author), CAOM Ctr Appl Erbe Officinali & Frutti Minori, I-28100 Novara, Italy.
EM baj.germano@gmail.com
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NR 113
TC 1
Z9 1
U1 0
U2 11
PU Asia Pacific Acad Science Pte. Ltd.
PI SINGAPORE
PA 16 COLLYER QUAY #12-01 INCOME AT RAFFLES SINGAPORE, SINGAPORE, SINGAPORE
SN 0393-974X
EI 1724-6083
J9 J BIOL REG HOMEOS AG
JI J. Biol. Regul. Homeost. Agents
PD SEP
PY 2023
VL 37
IS 9
BP 4499
EP 4510
DI 10.23812/j.biol.regul.homeost.agents.20233709.440
PG 12
WC Endocrinology & Metabolism; Immunology; Medicine, Research &
   Experimental; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Immunology; Research & Experimental
   Medicine; Physiology
GA U1DP2
UT WOS:001082281900001
DA 2025-06-11
ER

PT J
AU Noruzi, Z
   Jayedi, A
   Farazi, M
   Asgari, E
   Firouzabadi, FD
   Akbarzadeh, Z
   Djafarian, K
   Shab-Bidar, S
AF Noruzi, Zahra
   Jayedi, Ahmad
   Farazi, Mena
   Asgari, Elaheh
   Dehghani Firouzabadi, Fatemeh
   Akbarzadeh, Zahra
   Djafarian, Kurosh
   Shab-Bidar, Sakineh
TI Association of Oxidative Balance Score with the Metabolic Syndrome in a
   Sample of Iranian Adults
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Article
ID ANTIOXIDANT EXPOSURES; INSULIN-RESISTANCE; COLORECTAL ADENOMA;
   PROSTATE-CANCER; STRESS; RISK; INFLAMMATION; INCIDENT; RELIABILITY;
   COMPONENTS
AB Objective. We aimed to assess the association of the oxidative balance score (OBS) with metabolic syndrome (MetS) in adults. Design. A population-based cross-sectional study Setting. Health centers from five districts in Tehran, Iran. Methods. We recruited 847 participants with an age range of 18-65 years. Dietary intake was assessed by a semiquantitative food frequency questionnaire with 168 items. The OBS was calculated by using the following 13 dietary and nondietary anti- and prooxidant components: dietary antioxidants (selenium, fiber, beta-carotene, vitamin D, vitamin C, vitamin E, and folate), dietary prooxidants (iron and saturated and polyunsaturated fatty acids), and nondietary anti- (physical activity) and prooxidants (smoking and obesity). The odds ratio (OR) and 95% confidence interval (CI) of the MetS and its components across tertiles of the OBS were calculated by logistic regression analysis, controlling for age, sex, energy intake, occupation, and educational level. Results. The range of OBS was between 16 and 39. Being in the top versus the bottom tertile of the OBS was not associated with the MetS (OR = 0.71, 95% CI 0.48-1.03; P = 0.07), after controlling for potential confounders. Higher OBS score was associated with a lower likelihood of abdominal obesity (OR 0.55, 95% CI: 0.38-0.81; P = 0.003) and increased diastolic blood pressure (OR 0.64, 95% CI: 0.41-0.99; P = 0.04). Higher OBS was not associated with other components of the MetS. Conclusion. Overall, the present study showed that there was no significant relationship between OBS and MetS in Tehranian adults.
C1 [Noruzi, Zahra; Jayedi, Ahmad; Farazi, Mena; Asgari, Elaheh; Dehghani Firouzabadi, Fatemeh; Akbarzadeh, Zahra; Shab-Bidar, Sakineh] Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Community Nutr, Tehran, Iran.
   [Djafarian, Kurosh] Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Clin Nutr, Tehran, Iran.
C3 Tehran University of Medical Sciences; Tehran University of Medical
   Sciences
RP Shab-Bidar, S (corresponding author), Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Community Nutr, Tehran, Iran.
EM zahranoruzi620@yahoo.com; ahmadjayedi@yahoo.com;
   mena_farazi@outlook.com; e.asgari1398@gmail.com; dehghanif39@gmail.com;
   akbarzadezahra@yahoo.com; kdjafarian@tums.ac.ir; s_shabbidar@tums.ac.ir
RI djafarian, kurosh/D-5563-2018; Jayedi, Ahmad/E-7237-2017; Shab-Bidar,
   Sakineh/H-9525-2017
OI Dehghani Firouzabadi, Fatemeh/0000-0002-6684-4615; Asgari,
   Elaheh/0000-0003-3778-4251; jayedi, ahmad/0000-0003-4231-3147;
   Shab-Bidar, Sakineh/0000-0002-0167-7174
FU Tehran University of Medical Sciences [40186]
FX The authors thank all those who participated in this study. This
   manuscript has been granted funding by the Tehran University of Medical
   Sciences (Grant No: 40186).
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NR 44
TC 20
Z9 20
U1 0
U2 0
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PD JUN 4
PY 2021
VL 2021
AR 5593919
DI 10.1155/2021/5593919
PG 9
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA SV8XN
UT WOS:000664101300001
PM 34188754
OA hybrid, Green Published
DA 2025-06-11
ER

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   Oosterhuis, Dorenda
   Mutsaers, Henricus A. M.
   Dekker, Frank J.
   Olinga, Peter
TI A Pathophysiological Model of Non-Alcoholic Fatty Liver Disease Using
   Precision-Cut Liver Slices
SO NUTRIENTS
LA English
DT Article
DE NAFLD; non-alcoholic fatty liver disease; ex vivo; pathophysiological
   model; metabolism; steatosis
ID ENDOPLASMIC-RETICULUM STRESS; DIETARY FRUCTOSE; IN-VITRO; SREBP-1C
   ACTIVATION; INSULIN-RESISTANCE; HEPATIC STEATOSIS; PROTEIN-SYNTHESIS;
   ADIPOSE-TISSUE; EXPRESSION; METABOLISM
AB Non-alcoholic fatty liver disease (NAFLD) is a common liver disorder closely related to metabolic syndrome. NAFLD can progress to an inflammatory state called non-alcoholic steatohepatitis (NASH), which may result in the development of fibrosis and hepatocellular carcinoma. To develop therapeutic strategies against NAFLD, a better understanding of the molecular mechanism is needed. Current in vitro NAFLD models fail to capture the essential interactions between liver cell types and often do not reflect the pathophysiological status of patients. To overcome limitations of commonly used in vitro and in vivo models, precision-cut liver slices (PCLSs) were used in this study. PCLSs, prepared from liver tissue obtained from male Wistar rats, were cultured in supraphysiological concentrations of glucose, fructose, insulin, and palmitic acid to mimic metabolic syndrome. Accumulation of lipid droplets was visible and measurable after 24 h in PCLSs incubated with glucose, fructose, and insulin, both in the presence and absence of palmitic acid. Upregulation of acetyl-CoA carboxylase 1 and 2, and of sterol responsive element binding protein 1c, suggests increased de novo lipogenesis in PCLSs cultured under these conditions. Additionally, carnitine palmitoyltransferase 1 expression was reduced, which indicates impaired fatty acid transport and disrupted mitochondrial beta-oxidation. Thus, steatosis was successfully induced in PCLSs with modified culture medium. This novel ex vivo NAFLD model could be used to investigate the multicellular and molecular mechanisms that drive NAFLD development and progression, and to study potential anti-steatotic drugs.
C1 [Prins, Grietje H.; Luangmonkong, Theerut; Oosterhuis, Dorenda; Mutsaers, Henricus A. M.; Olinga, Peter] Univ Groningen, Dept Pharmaceut Technol & Biopharm, NL-9712VM Groningen, Netherlands.
   [Luangmonkong, Theerut] Mahidol Univ, Dept Pharmacol, Fac Pharm, Bangkok 10400, Thailand.
   [Dekker, Frank J.] Univ Groningen, Dept Chem & Pharmaceut Biol, NL-9712VM Groningen, Netherlands.
C3 University of Groningen; Mahidol University; University of Groningen
RP Olinga, P (corresponding author), Univ Groningen, Dept Pharmaceut Technol & Biopharm, NL-9712VM Groningen, Netherlands.
EM G.G.H.Prins@rug.nl; theerut.lua@mahidol.edu; D.Oosterhuis@rug.nl;
   H.A.M.Mutsaers@rug.nl; F.J.Dekker@rug.nl; p.olinga@rug.nl
RI Olinga, Peter/J-2585-2015; Luangmonkong, Theerut/X-1722-2019; Mutsaers,
   Henricus/AAK-6321-2020; Dekker, Frank/H-2544-2014
OI Dekker, Frank/0000-0001-7217-9300; Olinga, Peter/0000-0003-4855-8452;
   Prins, Gerian/0000-0002-7225-9076; Luangmonkong,
   Theerut/0000-0003-3616-3787; Mutsaers, Henricus/0000-0002-9553-8860
FU ZonMw [114021010]
FX This work is part of the research programme "Meer Kennis met Minder
   Dieren" under project number 114021010, which is partly financed by
   ZonMw.
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NR 70
TC 20
Z9 21
U1 0
U2 8
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 2072-6643
J9 NUTRIENTS
JI Nutrients
PD FEB 27
PY 2019
VL 11
IS 3
AR 507
DI 10.3390/nu11030507
PG 14
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA HT2CN
UT WOS:000464370900002
PM 30818824
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU van den Berg, EH
   Gruppen, EG
   James, RW
   Bakker, SJL
   Dullaart, RPF
AF van den Berg, Eline H.
   Gruppen, Eke G.
   James, Richard W.
   Bakker, Stephan J. L.
   Dullaart, Robin P. F.
TI Serum paraoxonase 1 activity is paradoxically maintained in nonalcoholic
   fatty liver disease despite low HDL cholesterol
SO JOURNAL OF LIPID RESEARCH
LA English
DT Article
DE fatty liver index; high density lipoprotein cholesterol; hepatic
   steatosis index; metabolic syndrome; nonalcoholic fatty liver disease;
   paraoxonase-1; type 2 diabetes mellitus
ID CATALYTIC ACTIVITY CONCENTRATIONS; DENSITY-LIPOPROTEIN CHOLESTEROL;
   CARDIOVASCULAR-DISEASE; INSULIN-RESISTANCE; HEPATIC STEATOSIS; OXIDATIVE
   STRESS; 37-DEGREES-C; ENZYMES; RISK; EXPRESSION
AB Nonalcoholic fatty liver disease (NAFLD) is characterized by low HDL cholesterol, but the activity of the HDL-associated antioxidative enzyme paraoxonase-1 (PON-1) remains unclear. To determine the association of PON-1 with suspected NAFLD, we measured serum enzyme activity in 7,622 participants of the Prevention of Renal and Vascular End-Stage Disease cohort. A fatty liver index (FLI). 60, a proxy of NAFLD, was present in 2,083 participants (27.3%) and coincided with increased prevalence of T2D, metabolic syndrome (MetS), (central) obesity, elevated triglycerides, and low HDL cholesterol (all P < 0.001). In men and women combined, serum PON-1 activity did not vary according to elevated FLI (P = 0.98), whereas in men with elevated FLI PON-1 activity was increased (P = 0.016). In multivariable linear regression analyses (adjusted for age, sex, T2D, MetS, alcohol use, and smoking), PON-1 activity was unexpectedly associated with elevated FLI (beta = 0.083; P < 0.001). In a sensitivity analysis (n = 5,126) that excluded subjects with positive cardiovascular history, impaired estimated glomerular filtration rate, elevated urinary albumin excretion, and drug use, PON-1 activity was also independently associated with elevated FLI (beta = 0.045; P = 0.017). These results indicate that PON-1 is paradoxically maintained and may even be increased in NAFLD despite inverse associations with metabolic disorders and low HDL cholesterol.
C1 [van den Berg, Eline H.; Gruppen, Eke G.; Dullaart, Robin P. F.] Univ Groningen, Univ Med Ctr Groningen, Dept Endocrinol, Groningen, Netherlands.
   [van den Berg, Eline H.] Univ Groningen, Univ Med Ctr Groningen, Dept Gastroenterol & Hepatol, Groningen, Netherlands.
   [Gruppen, Eke G.; Bakker, Stephan J. L.] Univ Groningen, Univ Med Ctr Groningen, Dept Nephrol, Groningen, Netherlands.
   [James, Richard W.] Univ Geneva, Fac Med, Dept Internal Med, Geneva, Switzerland.
C3 University of Groningen; University of Groningen; University of
   Groningen; University of Geneva
RP Dullaart, RPF (corresponding author), Univ Groningen, Univ Med Ctr Groningen, Dept Endocrinol, Groningen, Netherlands.
EM r.p.f.dullaart@umcg.nl
RI Bakker, Stephan/J-4023-2015
OI Bakker, Stephan/0000-0003-3356-6791; van den Berg, Eline
   H./0000-0003-2703-2320
FU Dutch Kidney Foundation [E.033]; Dade Behring; Ausam; Roche; Abbott;
   Dutch Heart Foundation [2001-005]
FX Dr. J. E. Kootstra-Ros, Laboratory Center, University Medical Center
   Groningen, supervised the performance of the liver function tests. The
   Dutch Kidney Foundation supported the infrastructure of the PREVEND
   program from 1997 to 2003 (Grant E.033). The University Medical Center
   Groningen supported the infrastructure from 2003 to 2006. Dade Behring,
   Ausam, Roche, and Abbott financed laboratory equipment and reagents by
   which various laboratory determinations could be performed. The Dutch
   Heart Foundation supported studies on lipid metabolism (Grant 2001-005).
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NR 49
TC 17
Z9 17
U1 0
U2 4
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0022-2275
EI 1539-7262
J9 J LIPID RES
JI J. Lipid Res.
PD JAN
PY 2019
VL 60
IS 1
BP 168
EP 175
DI 10.1194/jlr.P088997
PG 8
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA HF7EG
UT WOS:000454401500017
PM 30455362
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Giorgio, V
   Mosca, A
   Alterio, A
   Alisi, A
   Grieco, A
   Nobili, V
   Miele, L
AF Giorgio, Valentina
   Mosca, Antonella
   Alterio, Arianna
   Alisi, Anna
   Grieco, Antonio
   Nobili, Valerio
   Miele, Luca
TI Elevated Hemoglobin Level Is Associated With Advanced Fibrosis in
   Pediatric Nonalcoholic Fatty Liver Disease
SO JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
LA English
DT Article
DE hemoglobin; nonalcoholic fatty liver disease; nonalcoholic
   steatohepatitis
ID CELL DISTRIBUTION WIDTH; OBSTRUCTIVE SLEEP-APNEA; METABOLIC SYNDROME;
   OXIDATIVE STRESS; NOCTURNAL HYPOXIA; RISK-FACTORS; NAFLD; PROGRESSION;
   OBESITY; TRIGGER
AB Objectives: Hemoglobin (Hb) and red blood cell distribution width (RDW) have been reported to be a risk marker of metabolic syndrome and nonalcoholic fatty liver disease (NAFLD). No study exists on pediatric populations. We aimed to determine the association between hematological parameters, and the severity of disease in children with biopsy-proven NAFLD.
   Methods: A total of 117 children (85 boys, mean age 12 years) with ultrasound evidence of NAFLD undergoing liver biopsy for diagnosis of nonalcoholic steatohepatitis (NASH), were prospectively enrolled between January 2011 and May 2013 in the setting of a tertiary care center. Children were screened for routine hematological and metabolic parameters, and causes of liver steatosis other than nonalcoholic were excluded, before liver biopsy was performed.
   Results: A total of 41 NAFLD (boys 29, mean age 11.2 years) and 76 NASH (boys 56, mean age 12.8 years) children were studied. Alanine transaminase levels were significantly higher in NASH group compared with NAFLD group (P = 0.05), and homeostatic model assessment of insulin resistance and triglycerides levels (P = 0.03 and 0.02, respectively). Regarding hematological components: red cell count, Hb, hematocrit, and RDW values were all significantly higher in NASH group compared with NAFLD group (P < 0.05 for each parameter).
   Conclusions: Children with NASH were more likely to have high levels of RDW compared to those with steatosis only. Moreover, NASH was associated with higher red cell count, Hb, and hematocrit. If confirmed in future follow-up studies, hematological parameters may be introduced in algorithms for NASH risk prediction.
C1 [Giorgio, Valentina; Grieco, Antonio; Miele, Luca] Univ Cattolica Sacro Cuore, Dept Pediat, Fdn Policlin Univ Agostino Gemelli, Rome, Italy.
   [Mosca, Antonella; Alterio, Arianna; Alisi, Anna; Nobili, Valerio] Bambino Gesu Children Hosp, Hepatometabol Dis Unit, Rome, Italy.
C3 Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli;
   IRCCS Bambino Gesu
RP Giorgio, V (corresponding author), Univ Cattolica Sacro Cuore, Dept Pediat, Fdn Policlin Gemelli, Largo Gemelli 8, I-00168 Rome, Italy.
EM valentinagiorgio1@gmail.com
RI mosca, antonella/JTS-6893-2023; Giorgio, Valentina/I-6110-2016; Nobili,
   Valerio/K-8670-2018; Alisi, Anna/A-6469-2010; Gasbarrini,
   Alessandro/K-4290-2018; Miele, Luca/C-2255-2015
OI Giorgio, Valentina/0000-0002-7448-8710; Miele, Luca/0000-0003-3464-0068;
   Mosca, Antonella/0000-0001-9646-7462; Alterio,
   Arianna/0000-0002-8561-1868; Alisi, Anna/0000-0001-7241-6329
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NR 34
TC 15
Z9 16
U1 0
U2 8
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0277-2116
EI 1536-4801
J9 J PEDIATR GASTR NUTR
JI J. Pediatr. Gastroenterol. Nutr.
PD AUG
PY 2017
VL 65
IS 2
BP 150
EP 155
DI 10.1097/MPG.0000000000001614
PG 6
WC Gastroenterology & Hepatology; Nutrition & Dietetics; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Nutrition & Dietetics; Pediatrics
GA FB9PO
UT WOS:000406471500005
PM 28737569
DA 2025-06-11
ER

PT J
AU Utzeri, E
   Usai, P
AF Utzeri, Erika
   Usai, Paolo
TI Role of non-steroidal anti-inflammatory drugs on intestinal permeability
   and nonalcoholic fatty liver disease
SO WORLD JOURNAL OF GASTROENTEROLOGY
LA English
DT Review
DE Non-steroidal anti-inflammatory drugs; Intestinal barrier; Intestinal
   permeability; Non-steroidal anti-inflammatory drugs - enteropathy;
   Nonalcoholic fatty liver disease; Nonalcoholic steatohepatitis;
   Microbiota; Metabolic syndrome; Proton pump inhibitors; Endotoxaemia
ID MITOCHONDRIAL BETA-OXIDATION; PROTON PUMP INHIBITORS; SMALL-BOWEL;
   BACTERIAL OVERGROWTH; CAUSALITY ASSESSMENT; POSSIBLE MECHANISM;
   BILIARY-EXCRETION; ADVERSE REACTIONS; GUT MICROBIOTA; MOUSE MODEL
AB The use of non-steroidal anti-inflammatory drugs (NSAIDs) is widespread worldwide thanks to their analgesic, anti-inflammatory and antipyretic effects. However, even more attention is placed upon the recurrence of digestive system complications in the course of their use. Recent data suggests that the complications of the lower gastro-intestinal tract may be as frequent and severe as those of the upper tract. NSAIDs enteropathy is due to enterohepatic recycling of the drugs resulting in a prolonged and repeated exposure of the intestinal mucosa to the compound and its metabolites. Thus leading to so-called topical effects, which, in turn, lead to an impairment of the intestinal barrier. This process determines bacterial translocation and toxic substances of intestinal origin in the portal circulation, leading to an endotoxaemia. This condition could determine a liver inflammatory response and might promote the development of nonalcoholic steatohepatitis, mostly in patients with risk factors such as obesity, metabolic syndrome and a high fat diet, which may induce a small intestinal bacterial overgrowth and dysbiosis. This alteration of gut microbiota may contribute to nonalcoholic fatty liver disease and its related disorders in two ways: firstly causing a malfunction of the tight junctions that play a critical role in the increase of intestinal permeability, and then secondly leading to the development of insulin resistance, body weight gain, lipogenesis, fibrogenesis and hepatic oxidative stress.
C1 [Utzeri, Erika; Usai, Paolo] Univ Cagliari, Dept Med Sci, Via Univ 40, I-09124 Cagliari, Italy.
C3 University of Cagliari
RP Usai, P (corresponding author), Univ Cagliari, Dept Med Sci, Via Univ 40, I-09124 Cagliari, Italy.
EM usaip@medicina.unica.it
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NR 88
TC 59
Z9 65
U1 0
U2 15
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 7041 Koll Center Parkway, Suite 160, PLEASANTON, CA, UNITED STATES
SN 1007-9327
EI 2219-2840
J9 WORLD J GASTROENTERO
JI World J. Gastroenterol.
PD JUN 14
PY 2017
VL 23
IS 22
BP 3954
EP 3963
DI 10.3748/wjg.v23.i22.3954
PG 10
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA EY4NW
UT WOS:000403955800002
PM 28652650
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Ros, E
AF Ros, Emilio
TI Nuts and CVD
SO BRITISH JOURNAL OF NUTRITION
LA English
DT Article
DE Nuts; Mediterranean diet; CVD; Cholesterol; Body weight
ID CORONARY-HEART-DISEASE; CARDIOVASCULAR RISK-FACTORS; MEDITERRANEAN DIET;
   METABOLIC SYNDROME; BLOOD-PRESSURE; ENDOTHELIAL FUNCTION; WALNUT
   CONSUMPTION; NITRIC-OXIDE; LIPID-LEVELS; WEIGHT-GAIN
AB Nuts are nutrient-dense foods with complex matrices rich in unsaturated fatty acids and other bioactive compounds, such as l-arginine, fibre, healthful minerals, vitamin E, phytosterols and polyphenols. By virtue of their unique composition, nuts are likely to beneficially affect cardiovascular health. Epidemiological studies have associated nut consumption with a reduced incidence of CHD in both sexes and of diabetes in women, but not in men. Feeding trials have clearly demonstrated that consumption of all kinds of nuts has a cholesterol-lowering effect, even in the context of healthy diets. There is increasing evidence that nut consumption has a beneficial effect on oxidative stress, inflammation and vascular reactivity. Blood pressure, visceral adiposity and the metabolic syndrome also appear to be positively influenced by nut consumption. Contrary to expectations, epidemiological studies and clinical trials suggest that regular nut consumption is not associated with undue weight gain. Recently, the PREvencion con DIeta MEDiterranea randomised clinical trial of long-term nutrition intervention in subjects at high cardiovascular risk provided first-class evidence that regular nut consumption is associated with a 50% reduction in incident diabetes and, more importantly, a 30% reduction in CVD. Of note, incident stroke was reduced by nearly 50% in participants allocated to a Mediterranean diet enriched with a daily serving of mixed nuts (15g walnuts, 7.5g almonds and 7.5g hazelnuts). Thus, it is clear that frequent nut consumption has a beneficial effect on CVD risk that is likely to be mediated by salutary effects on intermediate risk factors.
C1 [Ros, Emilio] Hosp Clin Barcelona, Lipid Clin, Endocrinol & Nutr Serv, Inst Invest Biomed August Pi i Sunyer, Barcelona, Spain.
   [Ros, Emilio] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr CIBEROBN, Madrid, Spain.
C3 University of Barcelona; Hospital Clinic de Barcelona; IDIBAPS; CIBER -
   Centro de Investigacion Biomedica en Red; CIBEROBN; Instituto de Salud
   Carlos III
RP Ros, E (corresponding author), Hosp Clin Barcelona, Lipid Clin, Endocrinol & Nutr Serv, Inst Invest Biomed August Pi i Sunyer, Barcelona, Spain.; Ros, E (corresponding author), Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr CIBEROBN, Madrid, Spain.
EM eros@clinic.ub.es
OI Ros, Emilio/0000-0002-2573-1294
FU Instituto de Salud Carlos III (ISCIII); Spanish Ministry of Economy and
   Competitiveness (CIBERobn); California Walnut Commission (CWC),
   Sacramento, CA
FX The present study was supported in part by grants from the Instituto de
   Salud Carlos III (ISCIII), the Spanish Ministry of Economy and
   Competitiveness (CIBERobn) and the California Walnut Commission (CWC),
   Sacramento, CA. Neither ISCIII nor CWC had any role in the design,
   analysis or writing of this article. CIBERobn is an initiative of the
   ISCIII, Spain.
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NR 85
TC 121
Z9 132
U1 1
U2 52
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1145
EI 1475-2662
J9 BRIT J NUTR
JI Br. J. Nutr.
PD APR
PY 2015
VL 113
SU 2
BP S111
EP S120
DI 10.1017/S0007114514003924
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA DH1AR
UT WOS:000372517300013
PM 26148914
OA Bronze
DA 2025-06-11
ER

PT J
AU Yamagishi, S
   Matsui, T
AF Yamagishi, Sho-ichi
   Matsui, Takanori
TI Pigment Epithelium-derived Factor (PEDF) and Cardiometabolic Disorders
SO CURRENT PHARMACEUTICAL DESIGN
LA English
DT Article
DE Atherosclerosis; cardiometabolic disorders; oxidative stress; PEDF
ID GLYCATION END-PRODUCTS; ENDOTHELIAL-GROWTH-FACTOR; DIABETIC VASCULAR
   COMPLICATIONS; SUPPRESSING RAC-1 ACTIVATION; CULTURED RETINAL PERICYTES;
   OXYGEN SPECIES GENERATION; CORONARY-ARTERY-DISEASE;
   TUMOR-NECROSIS-FACTOR; C-REACTIVE PROTEIN; INTERCELLULAR-ADHESION
   MOLECULE-1
AB The metabolic syndrome is strongly associated with insulin resistance and visceral obesity and consists of a constellation of factors such as diabetes, hypertension, dyslipidemia and non-alcoholic steatohepatits, which could in concert increase the risk for cardiovascular diseases (CVD). CVD, including myocardial infarction and stroke, is one of the leading causes of morbidity and mortality in the developed countries. Atherothrombosis, characterized by atherosclerotic plaque disruption and subsequent thrombus formation, contributes to the pathogenesis of CVD. Although therapeutic strategy for CVD has been progressed with anti-platelet and anti-thrombotic therapy, statins, and inhibitors of renin-angiotensin system, current therapeutic options may have therapeutic limitations because a substantial number of patients still experience CVD. Therefore, to develop novel therapeutic strategies that specifically target CVD is intensely desired. We and the others, have recently found that pigment epithelium-derived factor (PEDF), one of the serpins with neuronal differentiative activity, has insulin-sensitizing actions in the liver and adipose tissues, and exerts anti-inflammatory, anti-thrombogenic and vasculoprotective properties in vivo, thereby playing a protective role against the development and progression of the metabolic syndrome and CVD. In addition, serum levels of PEDF have been shown to increase in patients with visceral obesity, insulin resistance, diabetes, chronic kidney disease and CVD, thus being a novel biomarker of various cardiometabolic disorders. This paper discusses not only the role of PEDF, but also the clinical utility of measuring its levels in patients with various cardiometabolic disorders.
C1 [Yamagishi, Sho-ichi; Matsui, Takanori] Kurume Univ, Sch Med, Dept Pathophysiol & Therapeut Diabet Vasc Complic, Kurume, Fukuoka 8300011, Japan.
C3 Kurume University
RP Yamagishi, S (corresponding author), Kurume Univ, Sch Med, Dept Pathophysiol & Therapeut Diabet Vasc Complic, Kurume, Fukuoka 8300011, Japan.
EM shoichi@med.kurume-u.ac.jp
OI Matsui, Takanori/0000-0001-9506-7571
FU MEXT-Supported Program for the Strategic Research Foundation at Private
   Universities; Ministry of Education, Culture, Sports, Science and
   Technology (MEXT)
FX This work was supported in part by MEXT-Supported Program for the
   Strategic Research Foundation at Private Universities, the Ministry of
   Education, Culture, Sports, Science and Technology (MEXT) (S.
   Yamagishi).
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PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1381-6128
EI 1873-4286
J9 CURR PHARM DESIGN
JI Curr. Pharm. Design
PD APR
PY 2014
VL 20
IS 14
BP 2377
EP 2386
DI 10.2174/13816128113199990473
PG 10
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA AH5KR
UT WOS:000336168400014
PM 23844817
DA 2025-06-11
ER

PT J
AU Mingorance, C
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AF Mingorance, Carmen
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SO BRITISH JOURNAL OF NUTRITION
LA English
DT Article
DE Propionyl-L-carnitine; Metabolic syndrome; Obese Zucker rats; Insulin
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ID ENDOTHELIAL DYSFUNCTION; INSULIN-RESISTANCE; OXIDATIVE STRESS; METABOLIC
   SYNDROME; PERFUSION; HEART
AB Propionyl-L-carnitine (PLC) is an SCFA esterified to carnitine that plays an important role in fatty acid oxidation and energy expenditure, in addition to having a protective effect on the endothelium. In order to evaluate the effect of PLC oil an animal model of obesity, insulin resistance and, consequently, endothelial dysfunction, lean and obese Zucker rats (OZR) received either vehicle- or PLC-supplemented drinking water (200 mg/kg per d) for 20 weeks. Body weight, food intake, systolic blood pressure and heart rate were controlled weekly and an oral glucose tolerance test was performed. Fasting glucose, TAG, cholesterol, HDL, NEFA, adiponectin and insulin were analysed in serum. Visceral adipose tissue and liver were weighed and liver TAG liver composition was evaluated. Endothelial and vascular functions were assessed in the aorta and small mesenteric arteries by response to acetylcholine, sodium nitroprusside and phenylephrine (Phe) NO participation was evaluated after incubation with the NO synthase (NOS) inhibitor N-G-nitro-L-arginine methyl ester (L-NAME) and endothelial NOS protein expression by Western blotting. PLC decreased body-weight gain, food intake, adiposity, insulin serum concentration and TAG liver content and improved insulin resistance. Aortae front OZR receiving either vehicle or PLC exhibited a lower contractile response to Phe. PLC-treated OZR showed all enhanced release of endothelial NO upon the adrenergic stimulation. The protection of vascular function found after treatment with PLC in an animal model of insulin resistance supports the necessity of clinical trials showing the effect Of L-carnitine supplements oil metabolic disorders.
C1 [Mingorance, Carmen; Gonzalez del Pozo, Maria; Dolores Herrera, Maria; Alvarez de Sotomayor, Maria] Univ Seville, Fac Farm, Dept Farmacol, E-41012 Seville, Spain.
C3 University of Sevilla
RP de Sotomayor, MA (corresponding author), Univ Seville, Fac Farm, Dept Farmacol, E-41012 Seville, Spain.
EM aldesoto@us.es
RI Herrera, María/B-6373-2008; Alvarez de Sotomayor Paz, Maria/A-3838-2008;
   Gonzalez del Pozo, Maria/N-1742-2015
OI Alvarez de Sotomayor Paz, Maria/0000-0001-8466-1698; Gonzalez del Pozo,
   Maria/0000-0003-4858-938X; Herrera Gonzalez, Maria
   Dolores/0000-0001-7231-9537
FU Andalusian Regional Government [CTS-178]; Spanish Government, Ministry
   of Science and Technology
FX The present study was supported by funds obtained from the Andalusian
   Regional Government (CTS-178). C. M. is a fellow of the Spanish
   Government, Ministry of Science and Technology.
CR Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
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NR 29
TC 23
Z9 25
U1 0
U2 14
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1145
EI 1475-2662
J9 BRIT J NUTR
JI Br. J. Nutr.
PD OCT 28
PY 2009
VL 102
IS 8
BP 1145
EP 1153
DI 10.1017/S0007114509389230
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 513TX
UT WOS:000271347800006
PM 19545458
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Anagnostis, P
   Athyros, VG
   Tziomalos, K
   Karagiannis, A
   Mikhailidis, DP
AF Anagnostis, Panagiotis
   Athyros, Vasilios G.
   Tziomalos, Konstantinos
   Karagiannis, Asterios
   Mikhailidis, Dimitri P.
TI The Pathogenetic Role of Cortisol in the Metabolic Syndrome: A
   Hypothesis
SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Review
ID 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1; PITUITARY-ADRENAL AXIS;
   SERUM URIC-ACID; BODY-FAT DISTRIBUTION; CARDIOVASCULAR RISK-FACTORS;
   CORONARY-HEART-DISEASE; SUBCLINICAL CUSHINGS-SYNDROME; LOW-BIRTH-WEIGHT;
   ADIPOSE-TISSUE; INSULIN-RESISTANCE
AB Context: The metabolic syndrome (MetS) is a cluster of metabolic abnormalities that increase the risk for type 2 diabetes mellitus and vascular disease. The common characteristics of MetS and hypercortisolemic conditions such as Cushing's syndrome (CS) suggest that the pathogenesis of MetS and central obesity might involve prolonged and excessive exposure to glucocorticoids. The present review summarizes the evidence on the potential role of cortisol in the pathogenesis of MetS and discusses new therapeutic approaches for these patients.
   Evidence Acquisition: Using PubMed, we searched for publications during the last 20 yr regarding the possible pathogenetic role of cortisol in the development of MetS.
   Evidence Synthesis: Emerging data suggest that patients with MetS show hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis, which leads to a state of "functional hypercortisolism." The cause for this activation of the HPA axis remains uncertain but may be partly associated with chronic stress and/or low birth weight, which are both associated with increased circulating cortisol levels and greater responsiveness of the HPA axis. Increased exposure to cortisol contributes to increased fat accumulation in visceral depots. However, cortisol metabolism is not only centrally regulated. The action of 11 beta-hydroxysteroid dehydrogenase-1 at the tissue level also modulates cortisol metabolism. Increased 11 beta-hydroxysteroid dehydrogenase-1 activity in adipose tissue and liver might contribute to the development of several features of the MetS.
   Conclusions: MetS shares many characteristics of CS, and cortisol might play a role in the development of MetS at both a central and a peripheral level. (J Clin Endocrinol Metab 94: 2692-2701, 2009)
C1 [Tziomalos, Konstantinos; Mikhailidis, Dimitri P.] UCL, Sch Med, Dept Clin Biochem, Vasc Prevent Clin, London NW3 2QG, England.
   [Tziomalos, Konstantinos; Mikhailidis, Dimitri P.] UCL, Sch Med, Dept Surg, London NW3 2QG, England.
   [Anagnostis, Panagiotis] Hippokrateion Hosp, Endocrinol Clin, GR-54642 Thessaloniki, Greece.
   [Athyros, Vasilios G.; Karagiannis, Asterios] Aristotle Univ Thessaloniki, Sch Med, Propedeut Dept Internal Med 2, Hippokrat Hosp, GR-54642 Thessaloniki, Greece.
C3 University of London; University College London; UCL Medical School;
   University of London; University College London; UCL Medical School;
   Aristotle University of Thessaloniki
RP Mikhailidis, DP (corresponding author), UCL, Sch Med, Dept Clin Biochem, Vasc Prevent Clin, Royal Free Hosp Campus,Pond St, London NW3 2QG, England.
EM MIKHAILIDIS@aol.com
RI Mikhailidis, Dimitri/A-1869-2013; Anagnostis, Panagiotis/S-4803-2019;
   Athyros, V.G./H-5328-2019
OI Athyros, Vasilios/0000-0002-0882-8676
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NR 138
TC 474
Z9 526
U1 1
U2 74
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0021-972X
EI 1945-7197
J9 J CLIN ENDOCR METAB
JI J. Clin. Endocrinol. Metab.
PD AUG
PY 2009
VL 94
IS 8
BP 2692
EP 2701
DI 10.1210/jc.2009-0370
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 479UW
UT WOS:000268687700004
PM 19470627
OA Bronze
DA 2025-06-11
ER

PT J
AU Larter, CZ
   Yeh, MM
AF Larter, Claire Z.
   Yeh, Matthew M.
TI Animal models of NASH: Getting both pathology and metabolic context
   right
SO JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
LA English
DT Article
DE hepatic steatosis; high-fat diet; metabolic syndrome; non-alcoholic
   fatty liver disease; overnutrition
ID FATTY LIVER-DISEASE; ACTIVATED-RECEPTOR-ALPHA; CHOLINE-DEFICIENT DIET;
   METHIONINE ADENOSYLTRANSFERASE 1A; NONALCOHOLIC STEATOHEPATITIS;
   INSULIN-RESISTANCE; HEPATIC STEATOSIS; MITOCHONDRIAL ABNORMALITIES;
   DIABETES-MELLITUS; OXIDATIVE STRESS
AB Non-alcoholic fatty liver disease (NAFLD) is the most common cause of referral to liver clinics, and its progressive form, non-alcoholic steatohepatitis (NASH), can lead to cirrhosis and end-stage liver disease. The main risk factors for NAFLD/NASH are the metabolic abnormalities commonly observed in metabolic syndrome: insulin resistance, visceral obesity, dyslipidemia and altered adipokine profile. At present, the causes of progression from NAFLD to NASH remain poorly defined, and research in this area has been limited by the availability of suitable animal models of this disease. In the past, the main models used to investigate the pathogenesis of steatohepatitis have either failed to reproduce the full spectrum of liver pathology that characterizes human NASH, or the liver pathology has developed in a metabolic context that is not representative of the human condition. In the last few years, a number of models have been described in which the full spectrum of liver pathology develops in an appropriate metabolic context. In general, the underlying cause of metabolic defects in these models is chronic caloric overconsumption, also known as overnutrition. Overnutrition has been achieved in a number of different ways, including forced feeding, administration of high-fat diets, the use of genetically hyperphagic animals, or a combination of these approaches. The purpose of the present review is to critique the liver pathology and metabolic abnormalities present in currently available animal models of NASH, with particular focus on models described in approximately the last 5 years.
C1 [Larter, Claire Z.] Australian Natl Univ, ANU Med Sch, Canberra Hosp, Canberra, ACT, Australia.
   [Yeh, Matthew M.] Univ Washington, Med Ctr, Dept Pathol, Seattle, WA 98195 USA.
C3 Australian National University; Canberra Hospital; University of
   Washington; University of Washington Seattle
RP Larter, CZ (corresponding author), Canberra Hosp, Level 5,Bldg 10,Yamba Dr, Garran, ACT 2605, Australia.
EM claire.larter@anu.edu.au
FU Australian National Health and Medical Research Council (NHMRC) [358398]
FX The authors would like to thank Professor Geoff Farrell for his help in
   the preparation of this manuscript. Research in the authors' laboratory
   is supported by program grant 358398 from the Australian National Health
   and Medical Research Council (NHMRC).
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NR 81
TC 269
Z9 306
U1 0
U2 29
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0815-9319
EI 1440-1746
J9 J GASTROEN HEPATOL
JI J. Gastroenterol. Hepatol.
PD NOV
PY 2008
VL 23
IS 11
BP 1635
EP 1648
DI 10.1111/j.1440-1746.2008.05543.x
PG 14
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 375LI
UT WOS:000261115000007
PM 18752564
OA Green Published
DA 2025-06-11
ER

PT J
AU Nakata, S
   Tsutsui, M
   Shimokawa, H
   Suda, O
   Morishita, T
   Shibata, K
   Yatera, Y
   Sabanai, K
   Tanimoto, A
   Nagasaki, M
   Tasaki, H
   Sasaguri, Y
   Nakashima, Y
   Otsuji, Y
   Yanagihara, N
AF Nakata, Sei
   Tsutsui, Masato
   Shimokawa, Hiroaki
   Suda, Osamu
   Morishita, Tsuyoshi
   Shibata, Kiyoko
   Yatera, Yasuko
   Sabanai, Ken
   Tanimoto, Akihide
   Nagasaki, Machiko
   Tasaki, Hiromi
   Sasaguri, Yasuyuki
   Nakashima, Yasuhide
   Otsuji, Yutaka
   Yanagihara, Nobuyuki
TI Spontaneous myocardial infarction in mice lacking all nitric oxide
   synthase isoforms
SO CIRCULATION
LA English
DT Article
DE nitric oxide synthase; myocardial infarction; arteriosclerosis;
   angiotensin
ID RENIN-ANGIOTENSIN SYSTEM; CORONARY-ARTERY-DISEASE; VASCULAR
   SMOOTH-MUSCLE; ARGININE METHYL-ESTER; METABOLIC SYNDROME; DEFICIENT
   MICE; INSULIN-RESISTANCE; OXIDATIVE STRESS; ENDOTHELIUM; ADIPONECTIN
AB Background - The roles of nitric oxide (NO) in the cardiovascular system have been investigated extensively in pharmacological studies with NO synthase (NOS) inhibitors and in studies with NOS isoform - deficient mice. However, because of the nonspecificity of the NOS inhibitors and the compensatory interactions among NOS isoforms (nNOS, iNOS, and eNOS), the ultimate roles of endogenous NO derived from the entire NOS system are still poorly understood. In this study, we examined this point in mice deficient in all 3 NOS isoforms (triply n/i/eNOS(-/-) mice) that we have recently developed.
   Methods and Results - The triply n/i/eNOS(-/-) mice, but not singly eNOS(-/-) mice, exhibited markedly reduced survival, possibly due to spontaneous myocardial infarction accompanied by severe coronary arteriosclerotic lesions. Furthermore, the triply n/i/eNOS(-/-) mice manifested phenotypes that resembled metabolic syndrome in humans, including visceral obesity, hypertension, hypertriglyceridemia, and impaired glucose tolerance. Importantly, activation of the renin-angiotensin system was noted in the triply n/i/eNOS(-/-) mice, and long-term oral treatment with an angiotensin II type 1 receptor blocker significantly suppressed coronary arteriosclerotic lesion formation and the occurrence of spontaneous myocardial infarction and improved the prognosis of those mice, along with ameliorating the metabolic abnormalities.
   Conclusions - These results provide the first direct evidence that genetic disruption of the whole NOS system causes spontaneous myocardial infarction associated with multiple cardiovascular risk factors of metabolic origin in mice in vivo through the angiotensin II type 1 receptor pathway, demonstrating the critical role of the endogenous NOS system in maintaining cardiovascular and metabolic homeostasis.
C1 [Tsutsui, Masato; Sabanai, Ken; Nagasaki, Machiko; Yanagihara, Nobuyuki] Univ Occupat & Environm Hlth, Dept Pharmacol, Yahatanishi Ku, Sch Med, Kitakyushu, Fukuoka 8078555, Japan.
   [Nakata, Sei; Suda, Osamu; Morishita, Tsuyoshi; Shibata, Kiyoko; Yatera, Yasuko; Tasaki, Hiromi; Nakashima, Yasuhide; Otsuji, Yutaka] Univ Occupat & Environm Hlth, Sch Med, Dept Internal Med 2, Kitakyushu, Fukuoka 8078555, Japan.
   [Tanimoto, Akihide; Sasaguri, Yasuyuki] Univ Occupat & Environm Hlth, Sch Med, Dept Pathol, Kitakyushu, Fukuoka 8078555, Japan.
   [Shimokawa, Hiroaki] Tohoku Univ, Grad Sch Med, Dept Cardiovasc Med, Sendai, Miyagi 980, Japan.
C3 University of Occupational & Environmental Health - Japan; University of
   Occupational & Environmental Health - Japan; University of Occupational
   & Environmental Health - Japan; Tohoku University
RP Tsutsui, M (corresponding author), Univ Occupat & Environm Hlth, Dept Pharmacol, Yahatanishi Ku, Sch Med, 1-1 Iseigaoka, Kitakyushu, Fukuoka 8078555, Japan.
EM mt2498@med.uoeh-u.ac.jp
OI Shimokawa, Hiroaki/0000-0001-7534-4826
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NR 44
TC 100
Z9 112
U1 0
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0009-7322
EI 1524-4539
J9 CIRCULATION
JI Circulation
PD APR 29
PY 2008
VL 117
IS 17
BP 2211
EP 2223
DI 10.1161/CIRCULATIONAHA.107.742692
PG 13
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 294GQ
UT WOS:000255394300007
PM 18413498
DA 2025-06-11
ER

PT J
AU Frisbee, JC
AF Frisbee, JC
TI Reduced nitric oxide bioavailability contributes to skeletal muscle
   microvessel rarefaction in the metabolic syndrome
SO AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE
   PHYSIOLOGY
LA English
DT Article
DE microcirculation; regulation of skeletal muscle blood flow; functional
   hyperemia; active hyperemia
ID ZUCKER OBESE RATS; ENDOTHELIAL DYSFUNCTION; INSULIN-RESISTANCE;
   ASYMMETRIC DIMETHYLARGININE; SUPEROXIDE-PRODUCTION; OXYGEN;
   HYPERTENSION; CORONARY; INCREASES; DILATION
AB This study tested the hypothesis that chronically elevated oxidant stress contributes to impaired active hyperemia in skeletal muscle of obese Zucker rats (OZR) vs. lean Zucker rats (LZR) through progressive deteriorations in microvascular structure. Twelve-week-old LZR and OZR were given 4-hydroxy-2,2,6,6-tetramethylpiperidine1-oxyl ( tempol) in the drinking water for similar to 4 wk. Subsequently, perfusion of in situ gastrocnemius muscle was determined during incremental elevations in metabolic demand, while a contralateral skeletal muscle arteriole and the gastrocnemius muscle was removed to determine dilator reactivity, vessel wall mechanics, and microvessel density. Under control conditions, active hyperemia was impaired at all levels of metabolic demand in OZR, and this was correlated with a reduced microvessel density, increased arteriolar stiffness, and impaired dilator reactivity. Chronic tempol ingestion improved perfusion during moderate to high metabolic demand only and was associated with improved arteriolar reactivity and microvessel density; passive vessel mechanics were unaltered. Combined antioxidant therapy and nitric oxide synthase inhibition in OZR prevented much of the restored perfusion and microvessel density. In LZR, treatment with N-omega-nitro-L-arginine methyl ester (L-NAME) hydrochloride and hydralazine (to prevent hypertension) impaired active hyperemia, dilator reactivity, and microvessel density, although arteriolar distensibility was not altered. These results suggest that with the development of the metabolic syndrome, chronic reductions in nitric oxide bioavailability, in part via the scavenging actions of oxidative free radicals, contribute to a loss of skeletal muscle microvessels, leading to impaired muscle perfusion with elevated metabolic demand.
C1 W Virginia Univ, Sch Med, Robert C Byrd Hlth Sci Ctr, Dept Physiol & Pharmacol,Ctr Interdisciplinary Re, Morgantown, WV 26505 USA.
C3 West Virginia University
RP W Virginia Univ, Sch Med, Robert C Byrd Hlth Sci Ctr, Dept Physiol & Pharmacol,Ctr Interdisciplinary Re, POB 9105, Morgantown, WV 26505 USA.
EM jfrisbee@hsc.wvu.edu
OI Frisbee, Jefferson/0000-0003-2751-0599
FU NIDDK NIH HHS [R01 DK 64668] Funding Source: Medline
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NR 58
TC 97
Z9 116
U1 0
U2 2
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0363-6119
EI 1522-1490
J9 AM J PHYSIOL-REG I
JI Am. J. Physiol.-Regul. Integr. Comp. Physiol.
PD AUG
PY 2005
VL 289
IS 2
BP R307
EP R316
DI 10.1152/ajpregu.00114.2005
PG 10
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA 944UJ
UT WOS:000230455400005
PM 15802560
DA 2025-06-11
ER

PT J
AU Breyer, BN
   Sarma, AV
AF Breyer, Benjamin N.
   Sarma, Aruna V.
TI Hyperglycemia and Insulin Resistance and the Risk of BPH/LUTS: an Update
   of Recent Literature
SO CURRENT UROLOGY REPORTS
LA English
DT Article
DE Benign prostatic hyperplasia; BPH; Lower urinary tract symptoms; LUTS;
   Diabetes; Hyperglycemia; Insulin resistance
ID BENIGN PROSTATIC HYPERPLASIA; URINARY-TRACT SYMPTOMS; COMMUNITY-HEALTH
   SURVEY; METABOLIC SYNDROME; ERECTILE DYSFUNCTION; WHITE MEN;
   PROGRESSION; HYPERINSULINEMIA; INFLAMMATION; ASSOCIATION
AB Benign prostatic hyperplasia (BPH) and associated lower urinary tract symptoms (LUTS) are highly prevalent in older men and represent a substantial challenge to public health. Increasing epidemiologic evidence suggests that diabetes and associated hyperglycemia and insulin resistance significantly increase the risks of BPH and LUTS. Plausible pathophysiologic mechanisms to explain these associations include increased sympathetic tone, stimulation of prostate growth by insulin and related trophic factors, alterations in sex steroid hormone expression, and induction of systemic inflammation and oxidative stress. This article presents a comprehensive update of the current understanding of clinical and epidemiologic research on diabetes and BPH/LUTS, describes hypothesized pathophysiologic mechanisms linking these conditions, and recommends future directions for research.
C1 [Breyer, Benjamin N.] Univ Calif San Francisco, Dept Urol, San Francisco, CA 94110 USA.
   [Sarma, Aruna V.] Univ Michigan, Dept Urol & Epidemiol, Ann Arbor, MI 48109 USA.
C3 University of California System; University of California San Francisco;
   University of Michigan System; University of Michigan
RP Sarma, AV (corresponding author), Univ Michigan, Dept Urol & Epidemiol, 2800 Plymouth Rd,Room 109E, Ann Arbor, MI 48109 USA.
EM BBreyer@urology.ucsf.edu; asarma@umich.edu
FU NIDDK NIH HHS [P30 DK092926, K12 DK083021] Funding Source: Medline;
   National Institute of Diabetes and Digestive and Kidney Diseases
   [P30DK092926] Funding Source: NIH RePORTER
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NR 37
TC 36
Z9 40
U1 0
U2 10
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1527-2737
EI 1534-6285
J9 CURR UROL REP
JI Curr. Urol. Rep.
PD OCT 7
PY 2014
VL 15
IS 12
AR 462
DI 10.1007/s11934-014-0462-x
PG 6
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA AT9YD
UT WOS:000345278800002
PM 25287259
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Hushmandi, K
   Einollahi, B
   Aow, R
   Suhairi, SB
   Klionsky, DJ
   Aref, AR
   Reiter, RJ
   Makvandi, P
   Rabiee, N
   Xu, Y
   Nabavi, N
   Saadat, SH
   Farahani, N
   Kumar, AP
AF Hushmandi, Kiavash
   Einollahi, Behzad
   Aow, Rachel
   Suhairi, Suhana Binte
   Klionsky, Daniel J.
   Aref, Amir Reza
   Reiter, Russel J.
   Makvandi, Pooyan
   Rabiee, Navid
   Xu, Yi
   Nabavi, Noushin
   Saadat, Seyed Hassan
   Farahani, Najma
   Kumar, Alan Prem
TI Investigating the interplay between mitophagy and diabetic neuropathy :
   Uncovering the hidden secrets of the disease pathology
SO PHARMACOLOGICAL RESEARCH
LA English
DT Review
DE Diabetic neuropathies; Mitochondria; Mitophagy; Type 2 diabetes mellitus
ID MITOCHONDRIAL FISSION; PINK1/PARKIN-MEDIATED MITOPHAGY; PERIPHERAL
   NEUROPATHY; AUTOPHAGOSOME FORMATION; INTERACTING PROTEIN; METABOLIC
   SYNDROME; INSULIN-SECRETION; SENSORY NEURONS; SCHWANN-CELL; RISK-FACTORS
AB Mitophagy, the cellular process of selectively eliminating damaged mitochondria, plays a crucial role in maintaining metabolic balance and preventing insulin resistance, both key factors in type 2 diabetes mellitus (T2DM) development. When mitophagy malfunctions in diabetic neuropathy, it triggers a cascade of metabolic disruptions, including reduced energy production, increased oxidative stress, and cell death, ultimately leading to various complications. Thus, targeting mitophagy to enhance the process may have emerged as a promising therapeutic strategy for T2DM and its complications. Notably, plant-derived compounds with beta-cell protective and mitophagy-stimulating properties offer potential as novel therapeutic agents. This review highlights the intricate mechanisms linking mitophagy dysfunction to T2DM and its complications, particularly neuropathy, elucidating potential therapeutic interventions for this debilitating disease.
C1 [Hushmandi, Kiavash; Einollahi, Behzad; Saadat, Seyed Hassan] Baqiyatallah Univ Med Sci, Clin Sci Inst, Nephrol & Urol Res Ctr, Tehran, Iran.
   [Aow, Rachel; Suhairi, Suhana Binte; Kumar, Alan Prem] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Pharmacol, Singapore, Singapore.
   [Aow, Rachel; Suhairi, Suhana Binte; Kumar, Alan Prem] Natl Univ Singapore, NUS Ctr Canc Res N2CR, Yong Loo Lin Sch Med, Singapore, Singapore.
   [Klionsky, Daniel J.] Univ Michigan, Life Sci Inst, Ann Arbor, MI 48109 USA.
   [Aref, Amir Reza] Harvard Med Sch, Massachusetts Gen Hosp, Dept Surg, Boston, MA USA.
   [Reiter, Russel J.] UT Hlth San Antonio, Long Sch Med, Dept Cell Syst & Anat, San Antonio, TX USA.
   [Makvandi, Pooyan; Rabiee, Navid] Saveetha Univ, Saveetha Dent Coll & Hosp, SIMATS, Dept Biomat, Chennai 600077, India.
   [Makvandi, Pooyan] Chandigarh Univ, Univ Ctr Res & Dev, Mohali 140413, Punjab, India.
   [Xu, Yi] Wenzhou Med Univ, Quzhou Peoples Hosp, Dept Urol, Dept Sci & Technol,Quzhou Affiliated Hosp,NanoBioM, Quzhou 324000, Peoples R China.
   [Nabavi, Noushin; Farahani, Najma] Islamic Azad Univ, Farhikhtegan Hosp Tehran Med Sci, Farhikhtegan Med Convergence Sci Res Ctr, Tehran, Iran.
C3 Baqiyatallah University of Medical Sciences (BMSU); National University
   of Singapore; National University of Singapore; University of Michigan
   System; University of Michigan; Harvard University; Harvard Medical
   School; Harvard University Medical Affiliates; Massachusetts General
   Hospital; University of Texas System; University of Texas Health Science
   Center at San Antonio; Saveetha Institute of Medical & Technical
   Science; Saveetha Dental College & Hospital; Chandigarh University;
   Wenzhou Medical University; Islamic Azad University
RP Hushmandi, K (corresponding author), Baqiyatallah Univ Med Sci, Clin Sci Inst, Nephrol & Urol Res Ctr, Tehran, Iran.; Kumar, AP (corresponding author), Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Pharmacol, Singapore, Singapore.; Farahani, N (corresponding author), Islamic Azad Univ, Farhikhtegan Hosp Tehran Med Sci, Farhikhtegan Med Convergence Sci Res Ctr, Tehran, Iran.
EM houshmandi.kia7@ut.ac.ir; najmafarahani@gmail.com; apkumar@nus.edu.sg
RI Kumar, Alan/ABE-7492-2020; Saadat, Seyed/T-7950-2017; Rabiee,
   Navid/K-4407-2019; Makvandi, Pooyan/G-9237-2016
OI Rabiee, Navid/0000-0002-6945-8541; Makvandi, Pooyan/0000-0003-2456-0961
FU National Institutes of Health [GM131919]
FX A.P.K. was supported by grants from the Singapore Ministry of Ed-ucation
   (MOE-T2EP30120-0016) and National University of Singapore Seed Fund
   (NUHSRO/2023/039/RO5+6/Seed-Mar/04) . D.J.K. wasr supported by the
   National Institutes of Health (GM131919) .
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PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 1043-6618
EI 1096-1186
J9 PHARMACOL RES
JI Pharmacol. Res.
PD OCT
PY 2024
VL 208
AR 107394
DI 10.1016/j.phrs.2024.107394
EA SEP 2024
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WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA F4L8P
UT WOS:001309558900001
PM 39233055
OA hybrid
DA 2025-06-11
ER

PT J
AU Acquarone, E
   Monacelli, F
   Borghi, R
   Nencioni, A
   Odetti, P
AF Acquarone, E.
   Monacelli, F.
   Borghi, R.
   Nencioni, A.
   Odetti, P.
TI Resistin: A reappraisal
SO MECHANISMS OF AGEING AND DEVELOPMENT
LA English
DT Article
DE Resistin; Alzheimer's disease; Metabolism; Adipokines; Aging
ID C-REACTIVE PROTEIN; AMYLOID PRECURSOR PROTEIN; ACUTE CORONARY SYNDROME;
   INSULIN-RESISTANCE; SERUM RESISTIN; METABOLIC SYNDROME; PLASMA RESISTIN;
   ADIPOSE-TISSUE; ALZHEIMERS-DISEASE; CARDIOVASCULAR-DISEASE
AB From a biological point of view, aging can be considered a progressive inability of an organism to react to stress, maintain homeostasis, and survive unfavourable changes during post-maturational life. The expression of several adipokines changes during aging and for some changes, a role in the onset of chronic disease and frailty has been proposed. Among adipokines, resistin was shown in recent studies to play a key role in aging.
   Resistin is a small secreted protein that regulates glucose metabolism in mammalians. High resistin levels induce insulin resistance and exert proinflammatory effects. Consistently, resistin has been shown to play a pivotal role in various metabolic, inflammatory, and autoimmune diseases.
   Herein, the role of resistin as a molecular link between aging and age-related conditions was reviewed and the clinical implications of this knowledge discussed.
C1 [Acquarone, E.; Monacelli, F.; Borghi, R.; Nencioni, A.; Odetti, P.] Univ Genoa, Dept Internal Med & Med Specialties, DIMi, Viale Benedetto XV,6, I-16132 Genoa, Italy.
C3 University of Genoa
RP Monacelli, F (corresponding author), Univ Genoa, Dept Internal Med & Med Specialties, DIMi, Viale Benedetto XV,6, I-16132 Genoa, Italy.
EM fiammetta.monacelli@unige.it
RI Nencioni, Alessio/K-3692-2018; MONACELLI, FIAMMETTA/K-4198-2016
OI NENCIONI, ALESSIO/0000-0001-5068-8884; MONACELLI,
   FIAMMETTA/0000-0003-4303-7252
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NR 245
TC 127
Z9 132
U1 0
U2 5
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0047-6374
EI 1872-6216
J9 MECH AGEING DEV
JI Mech. Ageing Dev.
PD MAR
PY 2019
VL 178
BP 46
EP 63
DI 10.1016/j.mad.2019.01.004
PG 18
WC Cell Biology; Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Cell Biology; Geriatrics & Gerontology
GA HN9BE
UT WOS:000460492400006
PM 30650338
OA hybrid, Green Published
DA 2025-06-11
ER

PT S
AU Henao-Mejia, J
   Elinav, E
   Thaiss, CA
   Flavell, RA
AF Henao-Mejia, Jorge
   Elinav, Eran
   Thaiss, Christoph A.
   Flavell, Richard A.
BE Julius, D
TI Inflammasomes and Metabolic Disease
SO ANNUAL REVIEW OF PHYSIOLOGY, VOL 76
SE Annual Review of Physiology
LA English
DT Review; Book Chapter
DE Toll-like receptors; inflammasomes; obesity; metabolic syndrome
ID TUMOR-NECROSIS-FACTOR; DEFICIENCY DECREASES ATHEROSCLEROSIS; LINKS
   OXIDATIVE STRESS; RECEPTOR 4 DEFICIENCY; NLRP3 INFLAMMASOME;
   INSULIN-RESISTANCE; NALP3 INFLAMMASOME; ADIPOSE-TISSUE; CUTTING EDGE;
   FATTY-ACID
AB Innate immune response pathways and metabolic pathways are evolutionarily conserved throughout species and are fundamental to survival. As such, the regulation of whole-body and cellular metabolism is intimately integrated with immune responses. However, the introduction of new variables to this delicate evolutionarily conserved physiological interaction can lead to deleterious consequences for organisms as a result of inappropriate immune responses. In recent decades, the prevalence and incidence of metabolic diseases associated with obesity have dramatically increased worldwide. As a recently acquired human characteristic, obesity has exposed the critical role of innate immune pathways in multiple metabolic pathophysiological processes. Here, we review recent evidence that highlights inflammasomes as critical sensors of metabolic perturbations in multiple tissues and their role in the progression of highly prevalent metabolic diseases.
C1 [Henao-Mejia, Jorge; Flavell, Richard A.] Yale Univ, Sch Med, Dept Immunobiol, New Haven, CT 06520 USA.
   [Elinav, Eran; Thaiss, Christoph A.] Weizmann Inst Sci, Dept Immunol, IL-70100 Rehovot, Israel.
C3 Yale University; Weizmann Institute of Science
RP Henao-Mejia, J (corresponding author), Yale Univ, Sch Med, Dept Immunobiol, 333 Cedar St, New Haven, CT 06520 USA.
EM richard.flavell@yale.edu
RI Flavell, Richard/ACH-3245-2022; Elinav, Eran/ABE-8881-2020
FU Howard Hughes Medical Institute Funding Source: Medline
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NR 130
TC 105
Z9 118
U1 0
U2 21
PU ANNUAL REVIEWS
PI PALO ALTO
PA 4139 EL CAMINO WAY, PO BOX 10139, PALO ALTO, CA 94303-0897 USA
SN 0066-4278
EI 1545-1585
BN 978-0-8243-0376-1
J9 ANNU REV PHYSIOL
JI Annu. Rev. Physiol.
PY 2014
VL 76
BP 57
EP 78
DI 10.1146/annurev-physiol-021113-170324
PG 22
WC Physiology
WE Book Citation Index – Science (BKCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA BA4OF
UT WOS:000336055000005
PM 24274736
OA Bronze
DA 2025-06-11
ER

PT J
AU Pak, YK
   Jeong, JH
AF Pak, Youngmi Kim
   Jeong, Jae Hoon
TI Mitochondria: The Secret Chamber of Therapeutic Targets for
   Age-Associated Degenerative Diseases
SO BIOMOLECULES & THERAPEUTICS
LA English
DT Review
DE Mitochondria; Degenerative disease; Therapeutic; Mitochondrial medicine
ID TRANSCRIPTION-FACTOR; DNA CONTENT; OXIDATIVE STRESS; COPY NUMBER;
   DYSFUNCTION; MUTATIONS; BETA; METABOLISM; FISSION; ACCUMULATION
AB Mitochondria have long been recognized as ATP engines for the cell and recently as a dynamic and mobile organelles that control cell death and life. This exquisite organelle is the site of reactive oxygen species production and is highly vulnerable to exogenous stresses, resulting in catastrophic damage to the cell. Mitochondrial dysfunction is linked to a wide range of age-associated degenerative diseases, such as metabolic syndrome, cardiovascular disease, and neurodegenerative diseases. Understanding the molecular mechanisms of mitochondria-dependent pathogenesis may provide important strategies to treat these diseases. Indeed, mitochondria are emerging therapeutic targets for the mitochondria-related diseases. In this paper, we review the recent concepts of mitochondrial biology and how mitochondria are involved in age-associated degenerative diseases. Furthermore, we summarize the therapeutics which target to improve mitochondrial functions.
C1 [Pak, Youngmi Kim] Kyung Hee Univ, Dept Physiol, Coll Med, Seoul 130701, South Korea.
   [Jeong, Jae Hoon] Kyung Hee Univ, Dept Life & Nanopharmaceut Sci, Coll Med, Seoul 130701, South Korea.
C3 Kyung Hee University; Kyung Hee University
RP Pak, YK (corresponding author), Kyung Hee Univ, Dept Physiol, Coll Med, Seoul 130701, South Korea.
EM ykpak@khu.ac.kr
RI Kim, Young/C-9839-2015
OI Pak, Youngmi/0000-0001-7424-3484
FU 21C Frontier Functional Proteomics Project [FPR08A1-071]; Korean
   Ministry of Science Technology [20090084158, 20090084844, 20090063278]
FX This study was supported by FPR08A1-071 of 21C Frontier Functional
   Proteomics Project and NRF grants (20090084158, 20090084844, and
   20090063278) from the Korean Ministry of Science & Technology.
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NR 63
TC 10
Z9 10
U1 0
U2 12
PU KOREAN SOC APPLIED PHARMACOLOGY
PI SEOUL
PA RM 805, KOREAN FEDERATION SCIENCE & TECHNOLOGY B/D, 635-4 YEOKSAM-DONG,
   KANGNAM-GU, SEOUL, 135-703, SOUTH KOREA
SN 1976-9148
EI 2005-4483
J9 BIOMOL THER
JI Biomol. Ther.
PD JUL 31
PY 2010
VL 18
IS 3
BP 235
EP 245
DI 10.4062/biomolther.2010.18.3.235
PG 11
WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
GA 635XQ
UT WOS:000280691600001
OA Bronze
DA 2025-06-11
ER

PT J
AU de Freitas, ACP
   Torres, LC
   Duarte, MDMB
   da Matta, MC
   Casarini, DE
   Schor, N
AF Pinto de Freitas, Augustus Cesar
   Torres, Leuridan Cavalcante
   Menezes Bezerra Duarte, Maria do Carmo
   da Matta, Marina Cadena
   Casarini, Dulce Elena
   Schor, Nestor
TI Is oxidized low-density lipoprotein the connection between
   atherosclerosis, cardiovascular risk and nephrolithiasis?
SO UROLITHIASIS
LA English
DT Article
DE Nephrolithiasis; Atherosclerosis; Cardiovascular disease; Oxidative
   stress; Lipoproteins
ID METABOLIC SYNDROME; KIDNEY-STONES; CALCIFICATION; ASSOCIATION;
   ANTIBODIES; DISEASE; PLAQUES
AB Nephrolithiasis is considered a systemic disease. A link has been established between nephrolithiasis, cardiovascular disease (CVD), the metabolic syndrome and atherosclerosis. A significant correlation has been found between the high levels of oxidized low-density lipoprotein (oxLDL) and CVD and atherosclerosis, including coronary and femoral artery disease. To the best of our knowledge, oxLDL has not been evaluated in patients with nephrolithiasis. This study aimed to evaluate serum levels of oxLDL, anti-oxLDL antibodies(oxLDL-ab) and other markers of atherosclerosis in patients with nephrolithiasis, according to the severity of the disease. The population sample consisted of 94 patients of 30-70years of age with no symptoms of CVD who presented with renal calculi documented by ultrasonography, abdominal X-ray or computed tomography. The patients were divided into two groups: Group 1 (>= 3 stones) and Group 2 (1-2 stones). A comparison control group was formed with 21 healthy individuals. Enzyme-linked immunosorbent assays were used to assess oxLDL and oxLDL-ab. Lipid peroxidation indexes were also analyzed. Median serum oxLDL values were higher in Groups 1 and 2 compared to the control group (>= 3 stones, p=0.02; 1-2 stones, p=0.03). Median serum anti-oxLDL antibody levels were lower in the patients in Group 1 compared to the controls (p=0.03). There was no significant difference in the oxLDL/oxLDL-ab ratio between patients and controls. These findings suggest that this may be the link between nephrolithiasis and the greater incidence of atherosclerosis and cardiovascular disease in patients with kidney stones.
C1 [Pinto de Freitas, Augustus Cesar] Inst Med Integral Prof Fernando Figueira IMIP, Dept Nefrol, Caixa Postal 1393,Rua Coelhos 300, BR-50070550 Recife, PE, Brazil.
   [Torres, Leuridan Cavalcante; Menezes Bezerra Duarte, Maria do Carmo; da Matta, Marina Cadena] Inst Med Integral Prof Fernando Figueira IMIP, Translat Res Lab, Recife, PE, Brazil.
   [Casarini, Dulce Elena; Schor, Nestor] Univ Fed Sao Paulo UNIFESP, Dept Nephrol, Sao Paulo, SP, Brazil.
   [Torres, Leuridan Cavalcante] HCP, Recife, PE, Brazil.
C3 Instituto de Medicina Integral Professor Fernando Figueira (IMIP);
   Instituto de Medicina Integral Professor Fernando Figueira (IMIP);
   Universidade Federal de Sao Paulo (UNIFESP)
RP de Freitas, ACP (corresponding author), Inst Med Integral Prof Fernando Figueira IMIP, Dept Nefrol, Caixa Postal 1393,Rua Coelhos 300, BR-50070550 Recife, PE, Brazil.
EM gugacesar@uol.com.br
RI Casarini, Dulce/D-4091-2012; Torres, Leuridan/F-7187-2017
OI Casarini, Dulce/0000-0003-1912-4292
FU Fundacao de Amparo a Ciencia e Tecnologia do Estado de Pernambuco
   (FACEPE) [APQ-351-4.01/11]
FX This study was funded by the Fundacao de Amparo a Ciencia e Tecnologia
   do Estado de Pernambuco (FACEPE; Grant no. APQ-351-4.01/11).
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NR 44
TC 5
Z9 5
U1 1
U2 7
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 2194-7228
EI 2194-7236
J9 UROLITHIASIS
JI Urolithiasis
PD AUG
PY 2019
VL 47
IS 4
BP 347
EP 356
DI 10.1007/s00240-018-1082-6
PG 10
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA IJ1AM
UT WOS:000475631100004
PM 30302491
DA 2025-06-11
ER

PT J
AU Jahn, LA
   Hartline, L
   Rao, N
   Logan, B
   Kim, JJ
   Aylor, K
   Gan, LM
   Westergren, HU
   Barrett, EJ
AF Jahn, Linda A.
   Hartline, Lee
   Rao, Nagashree
   Logan, Brent
   Kim, Justin J.
   Aylor, Kevin
   Gan, Li-Ming
   Westergren, Helena U.
   Barrett, Eugene J.
TI Insulin Enhances Endothelial Function Throughout the Arterial Tree in
   Healthy But Not Metabolic Syndrome Subjects
SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Article
ID SKELETAL-MUSCLE; DIABETES-MELLITUS; GLUCOSE-UPTAKE; MICROVASCULAR
   RECRUITMENT; DEPENDENT VASODILATION; CARDIOVASCULAR EVENTS; OXIDATIVE
   STRESS; NITRIC-OXIDE; DYSFUNCTION; HUMANS
AB Context: Insulin reportedly impairs endothelial function in conduit arteries but improves it in resistance and microvascular arterioles in healthy humans. No studies have assessed endothelial function at three arterial levels in healthy or metabolic syndrome (METSYN) subjects.
   Objective: The objective of the study was to compare endothelial responsiveness of conduit arteries, resistance, and microvascular arterioles to insulin in healthy and METSYN subjects.
   Design: We assessed conduit, resistance, and microvascular arterial function in the postabsorptive and postprandial states and during euglycemic hyperinsulinemia (insulin clamp).
   Setting: The study was conducted at a clinical research unit.
   Participants: Age-matched healthy and METSYN subjects participated in the study.
   Interventions: We used brachial flow-mediated dilation, forearm postischemic flow velocity, and contrast-enhanced ultrasound to assess the conduit artery, resistance arteriole, and microvascular arteriolar endothelial function, respectively. We also assessed the conduit artery stiffness (pulse wave velocity and augmentation index) and measured the plasma concentrations of 92 cardiovascular disease biomarkers at baseline and after the clamp.
   Results: Postabsorptive and postprandial endothelial function was similar in controls and METSYN in all tested vessels. METSYN subjects were metabolically insulin resistant (P < .005). In controls, but not METSYN subjects, during euglycemic hyperinsulinemia, endothelial function improved at each level of arterial vasculature (P < .05 or less for each). Conduit vessel stiffness (pulse wave velocity) was increased in the METSYN group. Twelve of 92 biomarkers differed at baseline (P < .001) and remained different at the end of the insulin clamp.
   Conclusions: We conclude that insulin enhances arterial endothelial function in health but not in METSYN, and this vascular insulin resistance may underlie its increased cardiovascular disease risk.
C1 [Jahn, Linda A.; Hartline, Lee; Rao, Nagashree; Logan, Brent; Kim, Justin J.; Aylor, Kevin; Barrett, Eugene J.] Univ Virginia, Sch Med, Dept Med, Charlottesville, VA 22908 USA.
   [Barrett, Eugene J.] Univ Virginia, Sch Med, Dept Pharmacol, Charlottesville, VA 22908 USA.
   [Gan, Li-Ming; Westergren, Helena U.] Univ Gothenburg, Sahlgrenska Acad, Inst Med, Dept Mol & Clin Med, SE-41345 Gothenburg, Sweden.
   [Gan, Li-Ming] AstraZeneca, Dept Res & Dev, CVMD iMED, S-43183 Molndal, Sweden.
C3 University of Virginia; University of Virginia; University of
   Gothenburg; AstraZeneca
RP Barrett, EJ (corresponding author), Univ Virginia, Box 801510, Charlottesville, VA 22908 USA.
EM ejb8x@virginia.edu
RI Kim, Justin/LPQ-4253-2024
FU National Institutes of Health [RO1 DK 073759]; University of
   Virginia/AstraZeneca Research Alliance
FX This work was supported by National Institutes of Health Grant RO1 DK
   073759 and a grant from the University of Virginia/AstraZeneca Research
   Alliance.
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NR 39
TC 55
Z9 58
U1 0
U2 4
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0021-972X
EI 1945-7197
J9 J CLIN ENDOCR METAB
JI J. Clin. Endocrinol. Metab.
PD MAR
PY 2016
VL 101
IS 3
BP 1198
EP 1206
DI 10.1210/jc.2015-3293
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA DP9JA
UT WOS:000378811300053
PM 26756115
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Balcioglu, AS
   Durakoglugil, ME
   Çiçek, D
   Bal, UA
   Boyaci, B
   Müderrisoglu, H
AF Balcioglu, Akif Serhat
   Durakoglugil, Murtaza Emre
   Cicek, Davran
   Bal, Ugur Abbas
   Boyaci, Bulent
   Muderrisoglu, Haldun
TI Epicardial adipose tissue thickness and plasma homocysteine in patients
   with metabolic syndrome and normal coronary arteries
SO DIABETOLOGY & METABOLIC SYNDROME
LA English
DT Article
DE Angina pectoris; Coronary angiography; Epicardial fat; Homocysteine
ID LEFT-VENTRICULAR MASS; FATTY LIVER-DISEASE; PERICARDIAL FAT; NONCONTRAST
   CT; HEART-DISEASE; ASSOCIATION; RISK; PREDICTOR
AB Background: Increased epicardial adipose tissue thickness and plasma homocysteine levels are associated with Metabolic Syndrome (MS) and coronary artery disease. The majority of patients with MS have subclinical or manifest coronary artery disease. The aim of this study was to evaluate the relationship between MS and plasma homocysteine levels and epicardial adipose tissue thickness in subjects without epicardial coronary artery disease.
   Methods: Patients who underwent coronary angiography due to angina or equivocal symptoms and/or abnormal stress test results and were found to have normal coronary arteries were evaluated for the presence of MS. The study group comprised 75 patients with normal coronary arteries and MS, and the control group included 75 age-gender matched subjects without coronary artery disease or MS.
   Results: Epicardial adipose tissue thickness (5.8 +/- 1.9 mm vs. 4.3 +/- 1.6 mm, p <0.001) and plasma homocysteine levels (21.6 +/- 6.1 mu mol/L vs. 15.1 +/- 5.8 mu mol/L, p <0.001) were significantly higher in the MS group. Body mass index, triglyceride level, weight, age and waist circumference were positively and HDL cholesterol level were negatively correlated with both epicardial adipose tissue thickness and plasma homocysteine level. Epicardial adipose tissue thickness had the strongest correlation with plasma homocysteine level (r = 0.584, p < 0.001). For each 1 mm increase in epicardial adipose tissue thickness, an increase of 3.51 mu mol/L (95% CI: 2.24-4.79) in plasma homocysteine level was expected.
   Conclusions: We observed a close relationship between MS and epicardial adipose tissue thickness and plasma homocysteine levels, even in the absence of overt coronary artery disease.
C1 [Balcioglu, Akif Serhat; Cicek, Davran] Baskent Univ, Dept Cardiol, Med & Res Ctr Alanya, TR-07400 Antalya, Turkey.
   [Durakoglugil, Murtaza Emre] Recep Tayyip Erdogan Univ, Dept Cardiol, Fac Med, Rize, Turkey.
   [Bal, Ugur Abbas; Muderrisoglu, Haldun] Baskent Univ, Fac Med, Dept Cardiol, TR-06490 Ankara, Turkey.
   [Boyaci, Bulent] Gazi Univ, Dept Cardiol, Fac Med, Ankara, Turkey.
C3 Baskent University; Recep Tayyip Erdogan University; Baskent University;
   Gazi University
RP Balcioglu, AS (corresponding author), Baskent Univ, Dept Cardiol, Med & Res Ctr Alanya, Saray Mh Yunus Emre Cad 1, TR-07400 Antalya, Turkey.
EM serhatbalcioglu@gmail.com
RI cicek, davran/AAC-8036-2020; Durakoglugil, Emre/Q-3547-2019; Bal, Ugur
   Abbas/AAK-4322-2021; MUDERRISOGLU, IBRAHIM HALDUN/AAG-8233-2020
OI Bal, Ugur Abbas/0000-0002-9446-2518; MUDERRISOGLU, IBRAHIM
   HALDUN/0000-0002-9635-6313; Durakoglugil, Murtaza
   Emre/0000-0001-5268-4262
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NR 37
TC 12
Z9 12
U1 0
U2 6
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1758-5996
J9 DIABETOL METAB SYNDR
JI Diabetol. Metab. Syndr.
PD MAY 26
PY 2014
VL 6
AR 62
DI 10.1186/1758-5996-6-62
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA AI1PG
UT WOS:000336622800001
PM 24872849
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Sato, A
   Ohigashi, H
   Nozato, T
   Hikita, H
   Tamura, M
   Miyazaki, S
   Takahashi, Y
   Kuwahara, T
   Takahashi, A
   Hiroe, M
   Aonuma, K
AF Sato, Akira
   Ohigashi, Hirokazu
   Nozato, Toshihiro
   Hikita, Hiroyuki
   Tamura, Mieko
   Miyazaki, Shinsuke
   Takahashi, Yoshihide
   Kuwahara, Taishi
   Takahashi, Atsushi
   Hiroe, Michiaki
   Aonuma, Kazutaka
TI Coronary Artery Spatial Distribution, Morphology, and Composition of
   Nonculprit Coronary Plaques by 64-Slice Computed Tomographic Angiography
   in Patients With Acute Myocardial Infarction
SO AMERICAN JOURNAL OF CARDIOLOGY
LA English
DT Article
ID METABOLIC SYNDROME; ATHEROSCLEROTIC PLAQUES; STABLE ANGINA; FOLLOW-UP;
   LESIONS; CULPRIT; HEART; STATEMENT; PERFUSION; ACCURACY
AB Noninvasive identification of nonculprit lesions could improve preventive strategies for acute myocardial infarction (AMI). We assessed the morphology, composition, and spatial distribution of nonculprit coronary plaques in patients with AMI using computed tomographic angiography (CTA). A total of 64 patients with AMI underwent 64-slice CTA within 2 weeks after admission, and 162 symptomatic patients with stable angina pectoris (SAP) underwent CTA and stress myocardial perfusion imaging (MPI). Of these 226 patients, 16 were excluded from the analysis because of image artifacts. The mean number of nonculprit plaques per patient was 5.0 +/- 2.6 in the AMI group (n = 60), 4.2 +/- 2.6 in the SAP group with abnormal MPI findings (n = 67), and 1.1 +/ 1.3 in the SAP group with normal MPI findings (n = 83; p <0.01). Positive remodeling and low-attenuation plaques (<30 Hounsfield units) were more frequently observed in the AMI group (1.9 +/ 1.8) than in the SAP groups (0.6 +/- 0.9 with abnormal MPI findings and 0.2 +/- 0.4 with normal MPI findings; p <0.01). Within the AMI group, positive remodeling and low-attenuation plaques were present significantly more frequently in patients with metabolic syndrome than in those without (2.6 +/- 2.2 vs 1.4 +/- 1.4; p = 0.03) and was significantly more frequently distributed in the proximal segments of the left anterior descending artery (p <0.01). In conclusion, 64-slice CTA could provide promising information for preventive strategies by identifying nonculprit plaque morphology and zones at high risk of future events. (C) 2010 Elsevier Inc. All rights reserved. (Am J Cardiol 2010;105:930-935)
C1 [Sato, Akira; Aonuma, Kazutaka] Univ Tsukuba, Inst Clin Med, Div Cardiovasc, Grad Sch Comprehens Human Sci, Tsukuba, Ibaraki 305, Japan.
   [Ohigashi, Hirokazu; Nozato, Toshihiro; Hikita, Hiroyuki; Tamura, Mieko; Miyazaki, Shinsuke; Takahashi, Yoshihide; Kuwahara, Taishi; Takahashi, Atsushi] Yokosuka Kyosai Hosp, Ctr Cardiovasc, Yokosuka, Kanagawa, Japan.
   [Hiroe, Michiaki] Int Med Ctr Japan, Dept Cardiol, Tokyo, Japan.
C3 University of Tsukuba; Japan Institute for Health Security (JIHS);
   National Center for Global Health & Medicine - Japan
RP Sato, A (corresponding author), Univ Tsukuba, Inst Clin Med, Div Cardiovasc, Grad Sch Comprehens Human Sci, Tsukuba, Ibaraki 305, Japan.
EM asato@md.tsukuba.ac.jp
RI Sato, Akira/R-1244-2018
OI Sato, Akira/0000-0002-2438-1464
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NR 23
TC 21
Z9 23
U1 0
U2 4
PU EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
PI BRIDGEWATER
PA 685 ROUTE 202-206 STE 3, BRIDGEWATER, NJ 08807 USA
SN 0002-9149
EI 1879-1913
J9 AM J CARDIOL
JI Am. J. Cardiol.
PD APR 1
PY 2010
VL 105
IS 7
BP 930
EP 935
DI 10.1016/j.amjcard.2009.11.028
PG 6
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 582DP
UT WOS:000276576200005
PM 20346308
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Farrell, GC
   Larter, CZ
AF Farrell, GC
   Larter, CZ
TI Nonalcoholic fatty liver disease: From steatosis to cirrhosis
SO HEPATOLOGY
LA English
DT Review
ID HEPATIC TRIGLYCERIDE CONTENT; C-REACTIVE PROTEIN; INSULIN-RESISTANCE;
   HEPATOCELLULAR-CARCINOMA; NATURAL-HISTORY; VITAMIN-E; CRYPTOGENIC
   CIRRHOSIS; METABOLIC SYNDROME; MITOCHONDRIAL DYSFUNCTION; ALANINE
   AMINOTRANSFERASE
AB Nonalcoholic steatohepatitis (NASH), the lynchpin between steatosis and cirrhosis in the spectrum of nonalcoholic fatty liver disorders (NAFLD), was barely recognized in 1981. NAFLD is now present in 17% to 33% of Americans, has a worldwide distribution, and parallels the frequency of central adiposity, obesity, insulin resistance, metabolic syndrome and type 2 diabetes. NASH could be present in one third of NAFLD cases. Age, activity of steatohepatitis, and established fibrosis predispose to cirrhosis, which has a 7- to 10-year liver-related mortality of 12% to 25%. Many cases of cryptogenic cirrhosis are likely endstage NASH. While endstage NAFLD currently accounts for 4% to 10% of liver transplants, this may soon rise. Pathogenic concepts for NAFLD/NASH must account for the strong links with overnutrition and underactivity, insulin resistance, and genetic factors. Lipotoxicity, oxidative stress, cytokines, and other proinflammatory mediators may each play a role in transition of steatosis to NASH. The present "gold standard" management of NASH is modest weight reduction, particularly correction of central obesity achieved by combining dietary measures with increased physical activity. Whether achieved by "lifestyle adjustment" or anti-obesity surgery, this improves insulin resistance and reverses steatosis, hepatocellular injury, inflammation, and fibrosis. The same potential for "unwinding" fibrotic NASH is indicated by studies of the peroxisome proliferation activator receptor (PPAR)-gamma agonist "glitazones," but these agents may improve liver disease at the expense of worsening obesity. Future challenges are to approach NAFLD as a preventive public health initiative and to motivate affected persons to adopt a healthier lifestyle.
C1 Univ Sydney, Westmead Hosp, Westmeads Millennium Inst, Storr Liver Unit, Westmead, NSW 2145, Australia.
C3 NSW Health; Westmead Hospital; University of Sydney
RP Canberra Hosp, POB 81, Woden, ACT 2606, Australia.
EM gfarrell@u.washington.edu
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NR 157
TC 1932
Z9 2174
U1 2
U2 425
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0270-9139
EI 1527-3350
J9 HEPATOLOGY
JI Hepatology
PD FEB
PY 2006
VL 43
IS 2
SU 1
BP S99
EP S112
DI 10.1002/hep.20973
PG 14
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 010KN
UT WOS:000235193700019
PM 16447287
DA 2025-06-11
ER

PT J
AU Migeot, JA
   Duran-Aniotz, CA
   Signorelli, CM
   Piguet, O
   Ibáñez, A
AF Migeot, Joaquin A.
   Duran-Aniotz, Claudia A.
   Signorelli, Camilo M.
   Piguet, Olivier
   Ibanez, Agustin
TI A predictive coding framework of allostatic-interoceptive overload in
   frontotemporal dementia
SO TRENDS IN NEUROSCIENCES
LA English
DT Review
ID PLASMA NEUROFILAMENT LIGHT; BEHAVIORAL VARIANT; FUNCTIONAL CONNECTIVITY;
   NETWORK CONNECTIVITY; ALZHEIMERS-DISEASE; METABOLIC SYNDROME; SOCIAL
   COGNITION; NEURAL MARKERS; LOAD; STRESS
AB Recent allostatic-interoceptive explanations using predictive coding models propose that efficient regulation of the body's internal milieu is necessary to correctly anticipate environmental needs. We review this framework applied to understanding behavioral variant frontotemporal dementia (bvFTD) considering both allostatic overload and interoceptive deficits. First, we show how this frame-work could explain divergent deficits in bvFTD (cognitive impairments, behav-ioral maladjustment, brain atrophy, fronto-insular-temporal network atypicality, aberrant interoceptive electrophysiological activity, and autonomic disbalance). We develop a set of theory-driven predictions based on levels of allostatic interoception associated with bvFTD phenomenology and related physiopatho-logical mechanisms. This approach may help further understand the disparate behavioral and physiopathological dysregulations of bvFTD, suggesting targeted interventions and strengthening clinical models of neurological and psychiatric disorders.
C1 [Migeot, Joaquin A.; Duran-Aniotz, Claudia A.; Ibanez, Agustin] Univ Adolfo Ibanez, Latin Amer Brain Hlth Inst BrainLat, Santiago, Chile.
   [Migeot, Joaquin A.; Duran-Aniotz, Claudia A.] Univ Adolfo Ibanez, Ctr Social & Cognit Neurosci CSCN, Sch Psychol, Santiago, Chile.
   [Signorelli, Camilo M.] Univ Oxford, Dept Comp Sci, Oxford, England.
   [Signorelli, Camilo M.] Univ Liege, GIGA CRC Vivo Imaging, Physiol Cognit, Liege, Belgium.
   [Signorelli, Camilo M.] INSERM, Cognit Neuroimaging Unit, Saclay, France.
   [Piguet, Olivier] Univ Sydney, Sch Psychol, Sydney, NSW, Australia.
   [Piguet, Olivier] Univ Sydney, Brain & Mind Ctr, Sydney, NSW, Australia.
   [Ibanez, Agustin] Univ San Andres, Cognit Neurosci Ctr CNC, Buenos Aires, DF, Argentina.
   [Ibanez, Agustin] Consejo Nacl Invest Cient & Tecn, Buenos Aires, DF, Argentina.
   [Ibanez, Agustin] Univ Calif San Francisco, Global Brain Hlth Inst, San Francisco, CA 94143 USA.
   [Ibanez, Agustin] Trinity Coll Dublin, Dublin, Ireland.
C3 Universidad Adolfo Ibanez; Universidad Adolfo Ibanez; University of
   Oxford; University of Liege; Universite Paris Saclay; Institut National
   de la Sante et de la Recherche Medicale (Inserm); University of Sydney;
   University of Sydney; Universidad de San Andres Argentina; Consejo
   Nacional de Investigaciones Cientificas y Tecnicas (CONICET); University
   of California System; University of California San Francisco; Trinity
   College Dublin
RP Ibáñez, A (corresponding author), Univ Adolfo Ibanez, Latin Amer Brain Hlth Inst BrainLat, Santiago, Chile.; Ibáñez, A (corresponding author), Univ San Andres, Cognit Neurosci Ctr CNC, Buenos Aires, DF, Argentina.; Ibáñez, A (corresponding author), Consejo Nacl Invest Cient & Tecn, Buenos Aires, DF, Argentina.; Ibáñez, A (corresponding author), Univ Calif San Francisco, Global Brain Hlth Inst, San Francisco, CA 94143 USA.; Ibáñez, A (corresponding author), Trinity Coll Dublin, Dublin, Ireland.
RI Piguet, Olivier/HMO-9684-2023; Signorelli, Camilo/ABF-9725-2021; Ibanez,
   Agustin/H-7976-2015; Piguet, Olivier/C-9658-2011
OI Duran-Aniotz, Claudia/0000-0003-2503-8366; Ibanez,
   Agustin/0000-0001-6758-5101; Migeot, Joaquin/0000-0003-0647-5632;
   Piguet, Olivier/0000-0002-6696-1440
FU Takeda [CW2680521]; CONICET; ANID/FONDECYT Regular [1210195, 1210176];
   Sistema General de Regalias [BPIN2018000100059]; Universidad del Valle
   [CI 5316]; Programa Interdisciplinario de Investigacion Experimental en
   Comunicacion y Cognicion (PIIECC), Facultad de Humanidades, USACH;
   Alzheimer's Association GBHI [ALZ UK-20-639295]; National Institutes of
   Health, National Institutes of Aging [R01 AG057234]; Alzheimer's
   Association [SG-20-725707]; Rainwater Charitable foundation-Tau
   Consortium; Global Brain Health Institute; ANID/FONDEF [20I10152];
   ANID/FONDECYT [1210622]; ANID/PIA/ANILLOS [ACT210096]; FNRS MIS project
   'Evidencing sentience in low arousal states by probing brain-body
   interactions' (2020); Human Brain Project task, Brain Inspired
   Consciousness (BRICON); National Health and Medical Research Council of
   Australia Leadership Fellowship [GNT2008020];  [FONCYT-PICT 2017-1820]; 
   [ANID/FONDAP/15150012];  [2018-AARG591107]; National Institute on Aging;
   John E. Fogarty International Center for Advanced Study in the Health
   Sciences [R01AG057234] Funding Source: NIH RePORTER
FX A.I. is partially supported by grants from Takeda CW2680521; CONICET;
   ANID/FONDECYT Regular (1210195 and 1210176); FONCYT-PICT 2017-1820;
   ANID/FONDAP/15150012; Sistema General de Regalias (BPIN2018000100059),
   Universidad del Valle (CI 5316); Programa Interdisciplinario de
   Investigacion Experimental en Comunicacion y Cognicion (PIIECC),
   Facultad de Humanidades, USACH; Alzheimer's Association GBHI ALZ
   UK-20-639295; and the MULTIPARTNER CONSORTIUM TO EXPAND DEMENTIA
   RESEARCH IN LATIN AMERICA [ReDLat, supported by National Institutes of
   Health, National Institutes of Aging (R01 AG057234), Alzheimer's
   Association (SG-20-725707), Rainwater Charitable foundation-Tau
   Consortium, and Global Brain Health Institute)]. C.D.A. is partially
   supported by 2018-AARG591107, ANID/FONDEF ID20I10152, ANID/FONDECYT
   1210622, and ANID/PIA/ANILLOS ACT210096. C.M.S. is supported by the FNRS
   MIS project `Evidencing sentience in low arousal states by probing
   brain-body interactions' (2020) and Human Brain Project task, Brain
   Inspired Consciousness (BRICON). O.P. is supported by a National Health
   and Medical Research Council of Australia Leadership Fellowship
   (GNT2008020). The contents of this publication are solely the
   responsibility of the authors and do not represent the official views of
   these institutions.
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NR 136
TC 40
Z9 41
U1 0
U2 12
PU CELL PRESS
PI CAMBRIDGE
PA 50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA
SN 0166-2236
EI 1878-108X
J9 TRENDS NEUROSCI
JI Trends Neurosci.
PD NOV
PY 2022
VL 45
IS 11
BP 838
EP 853
DI 10.1016/j.tins.2022.08.005
EA OCT 2022
PG 16
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 5W5JL
UT WOS:000877949900007
PM 36057473
OA hybrid, Green Accepted, Green Published
DA 2025-06-11
ER

PT J
AU Moore, T
   Yanes, RE
   Calton, MA
   Vollrath, D
   Enns, GM
   Cowan, TM
AF Moore, Tereza
   Yanes, Rolando E.
   Calton, Melissa A.
   Vollrath, Douglas
   Enns, Gregory M.
   Cowan, Tina M.
TI AMP-independent activator of AMPK for treatment of mitochondrial
   disorders
SO PLOS ONE
LA English
DT Article
ID PROTEIN-KINASE; MECHANISMS; TARGET; MODEL
AB Mitochondrial diseases are a clinically heterogenous group of disorders caused by respiratory chain dysfunction and associated with progressive, multi-systemic phenotype. There is no effective treatment or cure, and no FDA-approved drug for treating mitochondrial disease. To identify and characterize potential therapeutic compounds, we developed anin vitroscreening assay and identified a group of direct AMP-activated protein kinase (AMPK) activators originally developed for the treatment of diabetes and metabolic syndrome. Unlike previously investigated AMPK agonists such as AICAR, these compounds allosterically activate AMPK in an AMP-independent manner, thereby increasing specificity and decreasing pleiotropic effects. The direct AMPK activator PT1 significantly improved mitochondrial function in assays of cellular respiration, energy status, and cellular redox. PT1 also protected against retinal degeneration in a mouse model of photoreceptor degeneration associated with mitochondrial dysfunction and oxidative stress, further supporting the therapeutic potential of AMP-independent AMPK agonists in the treatment of mitochondrial disease.
C1 [Moore, Tereza; Cowan, Tina M.] Stanford Univ, Dept Pathol, Palo Alto, CA 94304 USA.
   [Yanes, Rolando E.] Stanford Univ, Dept Immunol & Rheumatol, Palo Alto, CA 94304 USA.
   [Calton, Melissa A.; Vollrath, Douglas] Stanford Univ, Dept Genet, Palo Alto, CA 94304 USA.
   [Enns, Gregory M.] Stanford Univ, Dept Pediat Med Genet, Palo Alto, CA 94304 USA.
C3 Stanford University; Stanford University; Stanford University; Stanford
   University
RP Cowan, TM (corresponding author), Stanford Univ, Dept Pathol, Palo Alto, CA 94304 USA.
EM TCowan@stanfordhealthcare.org
OI Calton, Melissa/0000-0002-6908-9205
FU Raptor Pharmaceuticals; Mangold Foundation; Schwab Foundation; Grace
   Science Foundation; Dianne and Tad Taube Pediatric Neurodegenerative
   Disease Program; Stanford Maternal & Child Health Institute; National
   Eye Institute [R01 EY025790]
FX This work was supported by grants awarded to TM, GME, and TMC from
   Raptor Pharmaceuticals, the Mangold Foundation, the Schwab Foundation,
   the Grace Science Foundation, Dianne and Tad Taube Pediatric
   Neurodegenerative Disease Program, Stanford Maternal & Child Health
   Institute, and to MC and DV from the National Eye Institute (R01
   EY025790). The funders had no role in study design, data collection and
   analysis, decision to publish, or preparation of the manuscript.
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NR 34
TC 9
Z9 9
U1 0
U2 3
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD OCT 14
PY 2020
VL 15
IS 10
AR e0240517
DI 10.1371/journal.pone.0240517
PG 15
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA OG3XB
UT WOS:000581820200030
PM 33052980
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Sharma, P
   Sampath, H
AF Sharma, Priyanka
   Sampath, Harini
TI Mitochondrial DNA Integrity: Role in Health and Disease
SO CELLS
LA English
DT Review
DE mitochondrial DNA; base excision repair; metabolic syndrome;
   neurodegenerative diseases; aging
ID BASE EXCISION-REPAIR; D-LOOP REGION; DIFFERENTIAL
   INTRACELLULAR-LOCALIZATION; PURINE NUCLEOSIDE TRIPHOSPHATASE; HOGG1
   SER326CYS POLYMORPHISM; HEREDITARY OPTIC NEUROPATHY; MTDNA CONTROL
   REGION; RNA-POLYMERASE; OXIDATIVE DAMAGE; TRANSCRIPTION ELONGATION
AB As the primary cellular location for respiration and energy production, mitochondria serve in a critical capacity to the cell. Yet, by virtue of this very function of respiration, mitochondria are subject to constant oxidative stress that can damage one of the unique features of this organelle, its distinct genome. Damage to mitochondrial DNA (mtDNA) and loss of mitochondrial genome integrity is increasingly understood to play a role in the development of both severe early-onset maladies and chronic age-related diseases. In this article, we review the processes by which mtDNA integrity is maintained, with an emphasis on the repair of oxidative DNA lesions, and the cellular consequences of diminished mitochondrial genome stability.
C1 [Sharma, Priyanka; Sampath, Harini] Rutgers State Univ, Dept Nutr Sci, New Brunswick, NJ 08901 USA.
   [Sharma, Priyanka; Sampath, Harini] Rutgers State Univ, New Jersey Inst Food Nutr & Hlth, New Brunswick, NJ 08901 USA.
C3 Rutgers University System; Rutgers University New Brunswick; Rutgers
   University System; Rutgers University New Brunswick
RP Sampath, H (corresponding author), Rutgers State Univ, Dept Nutr Sci, New Brunswick, NJ 08901 USA.
EM priyanka.s1909@gmail.com; harini.sampath@rutgers.edu
RI Sharma, Priyanka/ACA-6407-2022
OI Sharma, Priyanka/0000-0001-6544-4284
FU NIH [DK100640]
FX This research was funded by NIH DK100640 to H.S.
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NR 210
TC 177
Z9 191
U1 1
U2 27
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2073-4409
J9 CELLS-BASEL
JI Cells
PD FEB
PY 2019
VL 8
IS 2
AR 100
DI 10.3390/cells8020100
PG 21
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA HO4MF
UT WOS:000460896000022
PM 30700008
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Ashraf, FUN
   Ghouri, K
   Someshwar, F
   Kumar, S
   Kumar, N
   Kumari, K
   Bano, S
   Ahmad, S
   Khawar, MH
   Ramchandani, L
   Salame, T
   Varrassi, G
   Khatri, M
   Kumar, S
   Mohamad, T
AF Ashraf, Fakhar Un Nisa
   Ghouri, Kashf
   Someshwar, Fnu
   Kumar, Sunny
   Kumar, Narendar
   Kumari, Komal
   Bano, Saira
   Ahmad, Saad
   Khawar, Muhammad Hasnain
   Ramchandani, Lata
   Salame, Tamara
   Varrassi, Giustino
   Khatri, Mahima
   Kumar, Satish
   Mohamad, Tamam
TI Insulin Resistance and Coronary Artery Disease: Untangling the Web of
   Endocrine-Cardiac Connections
SO CUREUS JOURNAL OF MEDICAL SCIENCE
LA English
DT Review
DE cardiovascular pathophysiology; metabolic syndrome; atherosclerosis;
   endocrine-cardiac connections; coronary artery disease; insulin
   resistance
ID MANAGEMENT
AB The relationship between insulin resistance and coronary artery disease (CAD) is a crucial study area in understanding the complex connection between metabolic dysregulation and cardiovascular morbidity. This scholarly investigation examines the intricate relationship between insulin resistance, a key characteristic of metabolic syndrome, and CAD development. The goal is to understand the detailed molecular and physiological connections that underlie the dangerous connection between the endocrine and cardiac systems. The recognition of insulin resistance as a key player in cardiovascular disease highlights the need to study the complex relationships between insulin signaling pathways and the development of atherosclerosis. This research analyzes the molecular processes by which insulin resistance leads to disruptions in lipid metabolism, inflammatory reactions, and malfunction of the blood vessel's inner lining. These processes create an environment that promotes the development and advancement of CAD. As we begin this scientific exploration, it becomes clear that insulin resistance acts as a metabolic indicator and a potent mediator of endothelial dysfunction, oxidative stress, and systemic inflammation. The complex interaction between insulin -sensitive tissues and the vascular endothelium plays a crucial role in defining the pathophysiological landscape of CAD. Furthermore, this discussion highlights the mutual interaction between the endocrine and cardiac systems, where CAD produced by myocardial ischemia worsens insulin resistance through complex molecular pathways. Discovering new therapeutic targets that disrupt the harmful cycle between insulin resistance and the development of CAD shows potential for creating specific therapies to reduce cardiovascular risk in people with insulin resistance. This study aims to clarify the complexities of the connection between the endocrine system and the heart, establishing the basis for a thorough comprehension of how insulin resistance contributes to the development and advancement of CAD.
C1 [Ashraf, Fakhar Un Nisa] Royal Wolverhampton Natl Hlth Serv NHS Trust, Med, Wolverhampton, England.
   [Ghouri, Kashf] Mayo Hosp, Endocrinol, Lahore, Pakistan.
   [Someshwar, Fnu; Kumar, Sunny] Liaquat Natl Hosp & Med Coll, Med, Karachi, Pakistan.
   [Kumar, Narendar] Burjeel Hosp, Internal Med, Abu Dhabi, U Arab Emirates.
   [Kumari, Komal] New Med Ctr NMC Royal Family Med Ctr, Med, Abu Dhabi, U Arab Emirates.
   [Bano, Saira] Faisalabad Med Coll & Univ, Med, Faisalabad, Pakistan.
   [Ahmad, Saad] Shalamar Med & Dent Coll, Med, Lahore, Pakistan.
   [Khawar, Muhammad Hasnain] Mayo Hosp, Med, Lahore, Pakistan.
   [Ramchandani, Lata] Peoples Univ Med & Hlth Sci Women, Med, Nawabshah, Pakistan.
   [Salame, Tamara] Wayne State Univ, Med, Detroit, MI USA.
   [Varrassi, Giustino] Paolo Procacci Fdn, Pain Med, Rome, Italy.
   [Khatri, Mahima] Dow Univ Hlth Sci, Civil Hosp Karachi, Internal Med Cardiol, Karachi, Pakistan.
   [Kumar, Satish] Shaheed Mohtarma Benazir Bhutto Med Coll, Med, Karachi, Pakistan.
   [Mohamad, Tamam] Wayne State Univ, Cardiol, Detroit, MI USA.
C3 Wayne State University; Dow University of Health Sciences; Wayne State
   University
RP Khatri, M (corresponding author), Dow Univ Hlth Sci, Civil Hosp Karachi, Internal Med Cardiol, Karachi, Pakistan.
EM mahimak8465@gmail.com
RI kumar, satish/HJJ-1128-2023; KUMARI, KOMAL/IQU-8208-2023; Varrassi,
   Giustino/H-8455-2019; Bano, Saira/AGY-5502-2022
FU Paolo Procacci Foundation
FX Acknowledgements We extend our heartfelt gratitude to the Paolo Procacci
   Foundation for their unwavering support, which has greatly enriched the
   success of this paper.
CR Amer Diabet Assoc, 2021, DIABETES CARE, V44, pS15, DOI 10.2337/dc21-S002
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NR 25
TC 6
Z9 7
U1 0
U2 0
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
EI 2168-8184
J9 CUREUS J MED SCIENCE
JI Cureus J Med Sci
PD DEC 25
PY 2023
VL 15
IS 12
AR e51066
DI 10.7759/cureus.51066
PG 12
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA IB2X3
UT WOS:001163807300025
PM 38269234
OA gold
DA 2025-06-11
ER

PT J
AU Al-Lahham, S
   Jaradat, N
   Hamayel, A
   Assaassa, A
   Hammad, F
   Mosa, A
   Nafaa, F
   Ghanim, M
   Dwikat, M
   AlQub, M
   Rahim, AA
   Barqawi, A
AF Al-Lahham, Sa'ad
   Jaradat, Nidal
   Hamayel, Abdallah
   Assaassa, Abdalrahman
   Hammad, Faris
   Mosa, Ahmed
   Nafaa, Fouad
   Ghanim, Mustafa
   Dwikat, Majdi
   AlQub, Malik
   Rahim, Ahmad Abdal
   Barqawi, Abdelkarem
TI Hexane extract of Curcuma longa L. inhibits the activities
   of key enzymes and pro- inflammatory adipokines linked to obesity
SO EUROPEAN JOURNAL OF INTEGRATIVE MEDICINE
LA English
DT Article
DE Curcuminoids; Inflammation; Human adipose tissue; Curcuma longa L;
   Obesity
ID ADIPOSE-TISSUE; METABOLIC SYNDROME; DOUBLE-BLIND; OXIDATIVE STRESS;
   CONTROLLED-TRIAL; PROPIONIC-ACID; PLACEBO; OVERWEIGHT; CURCUMINOIDS;
   SUPPLEMENTATION
AB Introduction: Obesity is associated with chronic activation of low-grade inflammation produced mainly from adipose tissue, which is implicated in the pathogenesis of several diseases. Consequently, there is a need to screen for new anti-obesity medicines. Clinical evidence regarding the anti-obesity properties of Curcuma longa L. (C. longa) is inconclusive. Therefore, we aimed to investigate for the first time the influence of curcuminoids and hexane extract derived from C. longa 1) On the release of pro-inflammatory adipokines from human abdominal subcutaneous adipose tissue (ASAT) and induced-mononuclear cells (iMC) and 2) On the activities of alpha-amylase, alpha-glucosidase, and lipase enzymes. Methods: ASAT explants and lipopolysaccharide-iMC were treated with either curcuminoids or hexane extract of C. longa. Protein concentration, anti-lipase, anti-amylase and anti-glucosidase activities were evaluated employing colorimetric methods. Results: Treatment of ASAT with curcuminoids or hexane extract inhibited the secretion of leptin, CCL5 and Il-113. Treatment of iMC cells with curcuminoids or hexane extract inhibited the secretion of TNF-alpha, CCL5 and Il-113 and leptin was not detected. Curcuminoids possessed a significant inhibitory activity against lipase, alpha-amylase and alpha-glucosidase in a dose-dependent manner. Conclusion: We demonstrate for the first time that curcuminoids and C. longa exert anti-inflammatory properties on human ASAT and iMC and inhibit the activities of lipase, alpha-amylase and alpha-glucosidase enzymes. This suggests that C. longa and curcuminoids not only may ameliorate obesity-associated comorbidities such as metabolic syndrome but may be used as a preventive approach against obesity. However, this requires in vivo validation.
C1 [Al-Lahham, Sa'ad; Hamayel, Abdallah; Assaassa, Abdalrahman; Hammad, Faris; Mosa, Ahmed; Ghanim, Mustafa; Dwikat, Majdi; AlQub, Malik; Rahim, Ahmad Abdal] An Najah Natl Univ, Fac Med & Hlth Sci, Dept Biomed Sci, Nablus, Palestine.
   [Jaradat, Nidal] An Najah Natl Univ, Fac Med & Hlth Sci, Dept Pharm, Nablus, Palestine.
   [Nafaa, Fouad] Rafidia Hosp, Dept Surg, Nablus, Palestine.
   [Barqawi, Abdelkarem] An Najah Natl Univ Hosp, Dept Surg, Nablus, Palestine.
C3 An Najah National University; An Najah National University; An Najah
   National University
RP Al-Lahham, S (corresponding author), An Najah Natl Univ, Fac Med & Hlth Sci, Dept Biomed Sci, Nablus, Palestine.
EM saedallahham@gmail.com
RI Jaradat, Nidal/I-3136-2016
OI Hammad, Faris/0000-0002-5355-140X; Barqawi,
   Abdelkarim/0000-0002-0503-8046
FU An-Najah National University
FX We are grateful to An-Najah National University for providing financial
   assistance for this work, which was made feasible via an undergraduate
   project. We also thank Rafidia and An-Najah National University Hospital
   for supplying us with human adipose tissue samples.
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NR 50
TC 5
Z9 5
U1 1
U2 4
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1876-3820
EI 1876-3839
J9 EUR J INTEGR MED
JI Eur. J. Integr. Med.
PD DEC
PY 2021
VL 48
AR 101400
DI 10.1016/j.eujim.2021.101400
EA NOV 2021
PG 9
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA ZB1OK
UT WOS:000756619900001
DA 2025-06-11
ER

PT J
AU Okosun, IS
   Airhihenbuwa, C
   Henry, TL
AF Okosun, Ike S.
   Airhihenbuwa, Collins
   Henry, Tracey L.
TI Allostatic load, metabolic syndrome and self-rated health in
   overweight/obese Non-Hispanic White, non-Hispanic Black and Mexican
   American adults
SO DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS
LA English
DT Article
DE Self-rated health; Allostatic load; Chronic stress; Physiological
   dysregulations; Bodywear and tear
ID NATIONAL-HEALTH; ASSOCIATION; INFLAMMATION; PREVALENCE; MACARTHUR; TIME;
   LIFE
AB Aim: This study examined the associations of high allostatic load (h_ALS) and metabolic syndrome (MetS) with and self-rated poor health (SRPH) in overweight/obese non- Hispanic White (NHW), nonHispanic Black (NHB), and Mexican American (MA) adults.
   Methods: The 2015-16 and 2017-18 US National Health and Nutrition Examination Survey data (n = 4403) were used for this study.
   Results: Rates of h_ALS in overweight/obese NHW, NHW, and MA participants were 56.9%, 58.8%, and 51.9%, respectively (P<.05). The corresponding rates for MetS were 26.9%, 31.9%, and 46.5%, respectively. High ALS was associated with 2.19 (95% CI: 1.87-4.59), 1.82 (1.42-2.58), and 1.47 (95% CI: 1.08-1.64) increased odds of SRPH in overweight/obese NHW, NHB, and MA, respectively, after adjusting for age, education, gender, income, lifestyle behaviors, and marital status. The corresponding values for MetS were 1.86 (95% CI: 1.54-2.40), 2.77 (95% CI: 1.36-5.63), and 1.22 (95% CI: 1.06-2.32), respectively.
   Conclusions: The effect of h_ALS on SRPH was much stronger in NHW, while the effect of MetS was strongest among NHB overweight/obese adults. The result of this study provides further evidence in favor of race/ethnic-tailored interventions, including education and weight control to reduced risks of bodywear and tear and SRPH. (C) 2021 Diabetes India. Published by Elsevier Ltd. All rights reserved.
C1 [Okosun, Ike S.] Georgia State Univ, Sch Publ Hlth, Dept Populat Hlth Sci, Suite 461,Urban Life Bldg,POB 3984, Atlanta, GA 30302 USA.
   [Airhihenbuwa, Collins] Georgia State Univ, Sch Publ Hlth, Dept Hlth Policy & Behav Sci, Atlanta, GA 30302 USA.
   [Henry, Tracey L.] Emory Univ, Sch Med, Div Gen Med & Geriatr, Atlanta, GA 30303 USA.
C3 University System of Georgia; Georgia State University; University
   System of Georgia; Georgia State University; Emory University
RP Okosun, IS (corresponding author), Georgia State Univ, Sch Publ Hlth, Dept Populat Hlth Sci, Suite 461,Urban Life Bldg,POB 3984, Atlanta, GA 30302 USA.
EM iokosun@gsu.edu
RI Okosun, Solomon/AAR-3008-2020
OI Collins, Airhihenbuwa/0000-0002-8575-2214; Okosun, Ike
   S/0000-0001-8356-7894
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NR 40
TC 3
Z9 4
U1 0
U2 3
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1871-4021
EI 1878-0334
J9 DIABETES METAB SYND
JI Diabetes Metab. Syndr.-Clin. Res. Rev.
PD JUL-AUG
PY 2021
VL 15
IS 4
AR 102154
DI 10.1016/j.dsx.2021.05.027
EA JUN 2021
PG 7
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA UA2DN
UT WOS:000684974800046
PM 34186341
DA 2025-06-11
ER

PT J
AU Shi, HB
   Guo, XY
   Zhang, Q
   Wu, HM
   Du, HM
   Liu, L
   Wang, CJ
   Xia, Y
   Liu, X
   Li, CL
   Sun, SM
   Wang, X
   Zhou, M
   Jia, QY
   Zhao, HL
   Song, K
   Wei, DJ
   Niu, KJ
AF Shi, Hongbin
   Guo, Xiaoyan
   Zhang, Qing
   Wu, Hongmei
   Du, Huanmin
   Liu, Li
   Wang, Chongjin
   Xia, Yang
   Liu, Xing
   Li, Chunlei
   Sun, Shaomei
   Wang, Xing
   Zhou, Ming
   Jia, Qiyu
   Zhao, Honglin
   Song, Kun
   Wei, Dianjun
   Niu, Kaijun
TI Serum Immunoglobulin M Concentration Varies with Triglyceride Levels in
   an Adult Population: Tianjin Chronic Low-Grade Systemic Inflammation and
   Health (TCLSIHealth) Cohort Study
SO PLOS ONE
LA English
DT Article
ID LOW-DENSITY-LIPOPROTEIN; METABOLIC SYNDROME; IGM ANTIBODIES;
   RISK-FACTORS; FATTY-ACIDS; OBESITY; PREVALENCE; CHILDREN; IMPACT; LINKS
AB Persistent low-grade inflammation is thought to underlie the pathogenesis of many chronic diseases, such as cardiovascular diseases and metabolic syndrome. Autoimmunity is correlated with increased levels of chronic low-grade inflammation, and immunoglobulin M (IgM) is reactive to autoantigens and believed to be important for autoimmunity. Triglyceride (TG) is fatty acid carrier and initiator of oxidative stress, and it has been hypothesized that TG stimulates B cells to secrete IgM. However, few studies have investigated the relationship between TG and IgM in human populations. We designed a cross-sectional and prospective cohort study to evaluate how serum TG levels are related to IgM concentration. Participants were recruited from Tianjin Medical University General Hospital-Health Management Centre. Both a baseline cross-sectional (n = 10,808) and a prospective assessment (n = 2,615) were performed. Analysis of covariance was used in the cross-sectional analysis. After multiple adjustments for confounding factors, serum IgM level in the highest quartile of TG in males was significantly higher than levels in lower quartiles (P < 0.05). There was no significant difference between the four quartiles in females (P = 0.91). In follow-up analysis, a multiple linear regression model showed a significant and positive correlation between changes in IgM levels and changes of TG concentration in males (P = 0.04, standard beta coefficient = 0.882). This cross-sectional and cohort study is the first to show that serum concentration of IgM varies with TG levels in adult male populations. Further research is needed to explore the mechanism by which TG leads to increased IgM concentration.
C1 [Shi, Hongbin; Wei, Dianjun] Tianjin Med Univ, Hosp 2, Tianjin, Peoples R China.
   [Shi, Hongbin; Zhang, Qing; Liu, Li; Wang, Chongjin; Sun, Shaomei; Wang, Xing; Zhou, Ming; Jia, Qiyu; Zhao, Honglin; Song, Kun; Niu, Kaijun] Tianjin Med Univ, Gen Hosp, Hlth Management Ctr, Tianjin, Peoples R China.
   [Guo, Xiaoyan; Wu, Hongmei; Du, Huanmin; Xia, Yang; Liu, Xing; Li, Chunlei; Niu, Kaijun] Tianjin Med Univ, Nutr Epidemiol Inst, Tianjin, Peoples R China.
   [Guo, Xiaoyan; Wu, Hongmei; Du, Huanmin; Xia, Yang; Liu, Xing; Li, Chunlei; Niu, Kaijun] Tianjin Med Univ, Sch Publ Hlth, Tianjin, Peoples R China.
C3 Tianjin Medical University; Tianjin Medical University; Tianjin Medical
   University; Tianjin Medical University
RP Wei, DJ (corresponding author), Tianjin Med Univ, Hosp 2, Tianjin, Peoples R China.
EM nkj0809@gmail.com; nkj0809@163.com
RI Xia, Yang/AAW-9116-2021; Niu, Kaijun/ADD-6222-2022; LI,
   Cheuk-Wing/I-3255-2014
OI Niu, Kaijun/0000-0002-8772-2481; Xia, Yang/0000-0001-8783-1592
FU key technologies R&D program of Tianjin [11ZCGYSY05700, 12ZCZDSY20400,
   13ZCZDSY20200]; Technologies development program of Beichen District of
   Tianjin [bcws2013-21, bc2014-05]; technologies project of Tianjin Binhai
   New Area [2013-02-04, 2013-02-06]; Science Foundation of Tianjin Medical
   University [2010KY28]; technology fund of Tianjin Health Bureau, China
   [2013KZ099]
FX This study was supported by grants from the key technologies R&D program
   of Tianjin (Key Project: No. 11ZCGYSY05700, 12ZCZDSY20400, and
   13ZCZDSY20200), the Technologies development program of Beichen District
   of Tianjin (No. bcws2013-21 and bc2014-05), the technologies project of
   Tianjin Binhai New Area (No. 2013-02-04 and 2013-02-06), the Science
   Foundation of Tianjin Medical University (No. 2010KY28) and the
   technology fund of Tianjin Health Bureau (No. 2013KZ099), China.
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NR 38
TC 3
Z9 3
U1 0
U2 10
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD APR 27
PY 2015
VL 10
IS 4
AR e0124255
DI 10.1371/journal.pone.0124255
PG 13
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA CG9SB
UT WOS:000353659100041
PM 25915947
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Lee, DH
   Park, MY
   Shim, BJ
   Youn, HJ
   Hwang, HJ
   Shin, HC
   Jeon, HK
AF Lee, Dong Hyeon
   Park, Mi Yeon
   Shim, Byung Joo
   Youn, Ho Joong
   Hwang, Hye Jeong
   Shin, Hyeon Cheol
   Jeon, Hui Kyung
TI Effects of Ecklonia cava Polyphenol in Individuals with
   Hypercholesterolemia: A Pilot Study
SO JOURNAL OF MEDICINAL FOOD
LA English
DT Article
DE C-reactive protein; Ecklonia cava polyphenol; hemoglobin(A1c);
   hypercholesterolemia; metabolic syndrome; LDL-cholesterol
ID STRUCTURAL MECHANISM; OXIDATIVE STRESS; HEART-DISEASE; PHLOROTANNINS;
   STOLONIFERA; PHLOROGLUCINOL; INHIBITION; OBESITY; MEN
AB We evaluated the efficacy and safety of Ecklonia cava polyphenol (Seapolynol (TM), a polyphenol antioxidant and anti-inflammatory agent purified from E. cava) during a 12-week treatment period (400 mg orally once daily) in individuals with hypercholesterolemia and performed subgroup analysis for metabolic syndrome (MetS). As a noncomparative study, forty-six individuals (M:F = 22:24, mean age = 54 +/- 11 years) with fasting total cholesterol concentration >240 mg/dL or low-density lipoprotein cholesterol (LDL-C) concentration > 130 mg/dL were enrolled. Hip circumference (100 +/- 7 cm vs. 98 +/- 7 cm, P < .01), total cholesterol (244 +/- 25 mg/dL vs. 225 +/- 37 mg/dL, P < .01), LDL-C (161 +/- 24 mg/dL vs. 146 +/- 34 mg/dL, P < .01), and C-reactive protein (2.51 +/- 3.55 mg/L vs. 1.37 +/- 1.32 mg/L, P < .05) were significantly decreased without significant adverse effect. A differential assessment according to the presence [MetS(+) group, n = 18] and absence [MetS(-) group, n = 28] of MetS showed that Hb(A1c) decreased significantly following 12-week Seapolynol treatment in the MetS(+) compared with the MetS(-) group (-0.3% +/- 0.5% vs. 0.1% +/- 0.3%, P < .01). In conclusion, although our results showed that Seapolynol treatment is effective and safe without significant adverse events or abnormal laboratory findings during a 12-week period in individuals with hypercholesterolemia, more research in a larger population with a longer-term follow-up period in a randomized placebo-controlled study is needed to confirm the results.
C1 [Lee, Dong Hyeon; Park, Mi Yeon; Shim, Byung Joo; Youn, Ho Joong; Jeon, Hui Kyung] Catholic Univ Korea, Uijeongbu St Marys Hosp, Dept Internal Med, Div Cardiol, Uijongbu 480821, South Korea.
   [Hwang, Hye Jeong; Shin, Hyeon Cheol] Botamedi Res Ctr, Bellevue, WA USA.
C3 Catholic University of Korea
RP Jeon, HK (corresponding author), Catholic Univ Korea, Uijeongbu St Marys Hosp, Dept Internal Med, Div Cardiol, 65-1 Kumoh Dong, Uijongbu 480821, South Korea.
EM jhkmht@catholic.ac.kr
RI Shin, Hyeon-Cheol/KQT-9814-2024; Lee, Dong-Hyeon/AAM-3893-2021
OI Hwang, Hye Jeong/0000-0002-9236-536X; Lee,
   Dong-Hyeon/0009-0000-3856-3907; Shin, Hyeon-Cheol/0000-0001-6785-7111
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NR 27
TC 20
Z9 20
U1 0
U2 9
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1096-620X
EI 1557-7600
J9 J MED FOOD
JI J. Med. Food
PD NOV
PY 2012
VL 15
IS 11
BP 1038
EP 1044
DI 10.1089/jmf.2011.1996
PG 7
WC Chemistry, Medicinal; Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Food Science & Technology; Nutrition &
   Dietetics
GA 032XK
UT WOS:000310753500013
PM 23126663
DA 2025-06-11
ER

PT J
AU Moore-Carrasco, R
   Aranguez-Arellano, C
   Razmilic, I
   Toloza, L
   Morales, E
   Argiles, JM
   Palomo, I
AF Moore-Carrasco, R.
   Aranguez-Arellano, C.
   Razmilic, I.
   Toloza, L.
   Morales, E.
   Argiles, J. M.
   Palomo, I.
TI A high fat diet in CF-1 mice: An experimental model for metabolic
   syndrome
SO MOLECULAR MEDICINE REPORTS
LA English
DT Article
DE cardiovascular risk factors; high fat diet; CF-1 mice
ID SKELETAL-MUSCLE; INSULIN-RESISTANCE; OXIDATIVE STRESS; HIGH-CHOLESTEROL;
   RISK-FACTORS; OBESITY; RECEPTOR; ATHEROSCLEROSIS; PROTEIN; DEFECT
AB Cardiovascular diseases account for the majority of deaths worldwide. Many of their risk factors have been identified but, for their continued study, research centering on new murine models is of interest. In this study, a high fat diet (HFD) and a normal diet (ND) (25 and 4.4% fat, respectively) were tested over a 40-day period to induce the same metabolic alterations in CF-1 mice in two separate experiments. The parameters measured for these effects corresponded to the weight of ingested food and water, to the weight of the mice and their selected organs (adipose tissue, gastrocnemius, liver and heart), to their biochemical profile (glycemia, blood uric nitrogen, uric acid, triglycerides, cholesterol, proteins and albumin) and to the percentage of fat in their livers. The biochemical profile of the CF-1 mice fed a diet high in fat but balanced in proteins (16.9%) showed statistically significant increases in glycemia, cholesterol and triglyceride levels. A statistically significant increase in the weight of adipose tissue was also observed. No statistically significant differences were observed in the muscular mass of either of the groups of mice, but a high percentage of fat was found in the liver. The results lead to the conclusion that CF-1 mice fed a HFD develop metabolic alterations that correspond to an equivalent metabolic syndrome. This is important in the evaluation of the effects of various interventions, such as food, exercise and molecules, on metabolic alterations in mice induced by the intake of a HFD.
C1 [Moore-Carrasco, R.] Univ Talca, Fac Hlth Sci, Dept Clin Biochem & Inmunohematol, Programa Invest Factores Riesgo Enfermedad Cardio, Talca, Chile.
   [Razmilic, I.] Univ Talca, Inst Quim & Recursos Nat, Talca, Chile.
   [Morales, E.] Univ Catolica Maule, Escuela Med, Talca, Chile.
   [Argiles, J. M.] Univ Barcelona, Fac Biol, Dept Bioquim & Biol Mol, Barcelona, Spain.
C3 Universidad de Talca; Universidad de Talca; Universidad Catolica del
   Maule; University of Barcelona
RP Moore-Carrasco, R (corresponding author), Univ Talca, Fac Hlth Sci, Dept Clin Biochem & Inmunohematol, Programa Invest Factores Riesgo Enfermedad Cardio, POB 747, Talca, Chile.
EM rmoore@utalca.cl
RI Palomo, Iván/I-4321-2018; Argiles, Josep/L-5741-2014; Moore-Carrasco,
   Rodrigo/AAK-3349-2020
OI Palomo, Ivan/0000-0002-9618-8778; Moore-Carrasco,
   Rodrigo/0000-0003-4870-9660; Argiles, Josep M./0000-0003-4683-5428
FU Research Department [VAC 600377]; Research Program of Cardiovascular
   Disease Risk Factors (PIFRECV), Universidad de Talca, Chile
FX This study was supported by the Research Department (VAC 600377) and
   Research Program of Cardiovascular Disease Risk Factors (PIFRECV),
   Universidad de Talca, Chile.
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NR 38
TC 2
Z9 2
U1 0
U2 2
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1791-2997
EI 1791-3004
J9 MOL MED REP
JI Mol. Med. Rep.
PD MAY-JUN
PY 2008
VL 1
IS 3
BP 401
EP 405
PG 5
WC Oncology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Research & Experimental Medicine
GA 374QE
UT WOS:000261058000017
PM 21479424
DA 2025-06-11
ER

PT J
AU Hertzel, AV
   Yong, J
   Chen, XL
   Bernlohr, DA
AF Hertzel, Ann, V
   Yong, Jeongsik
   Chen, Xiaoli
   Bernlohr, David A.
TI Immune Modulation of Adipocyte Mitochondrial Metabolism
SO ENDOCRINOLOGY
LA English
DT Review
DE adipose; macrophage; mitochondria; inflammation
ID ADIPOSE-TISSUE; INSULIN-RESISTANCE; CELL-DEATH; T-CELLS; INFLAMMATION;
   MACROPHAGES; CLEAVAGE; HOMEOSTASIS; FERROPTOSIS; DYSFUNCTION
AB Immune cells infiltrate adipose tissue as a function of age, sex, and diet, leading to a variety of regulatory processes linked to metabolic disease and dysfunction. Cytokines and chemokines produced by resident macrophages, B cells, T cells and eosinophils play major role(s) in fat cell mitochondrial functions modulating pyruvate oxidation, electron transport and oxidative stress, branched chain amino acid metabolism, fatty acid oxidation, and apoptosis. Indeed, cytokine-dependent downregulation of numerous genes affecting mitochondrial metabolism is strongly linked to the development of the metabolic syndrome, whereas the potentiation of mitochondrial metabolism represents a counterregulatory process improving metabolic outcomes. In contrast, inflammatory cytokines activate mitochondrially linked cell death pathways such as apoptosis, pyroptosis, necroptosis, and ferroptosis. As such, the adipocyte mitochondrion represents a major intersection point for immunometabolic regulation of central metabolism.
C1 [Hertzel, Ann, V; Yong, Jeongsik; Bernlohr, David A.] Univ Minnesota, Dept Biochem Mol Biol & Biophys, Minneapolis, MN 55455 USA.
   [Chen, Xiaoli] Univ Minnesota, Dept Food Sci & Nutr, Minneapolis, MN 55455 USA.
C3 University of Minnesota System; University of Minnesota Twin Cities;
   University of Minnesota System; University of Minnesota Twin Cities
RP Bernlohr, DA (corresponding author), Univ Minnesota, Dept Biochem Mol Biol & Biophys, Minneapolis, MN 55455 USA.
EM Bernl001@umn.edu
OI Yong, Jeongsik/0000-0002-2758-0450
FU National Institutes of Health [DK053189, AG069819, DK123042,
   2R01GM113952]
FX Supported by National Institutes of Health (for NIH); DK053189 and
   AG069819 to D.A.B, DK123042 to X.C., and 2R01GM113952 to J.Y.
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NR 64
TC 8
Z9 8
U1 2
U2 13
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0013-7227
EI 1945-7170
J9 ENDOCRINOLOGY
JI Endocrinology
PD AUG 1
PY 2022
VL 163
IS 8
AR bqac094
DI 10.1210/endocr/bqac094
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 2X1CD
UT WOS:000824948900001
PM 35752995
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Govindaraj, R
   Paulraj, MG
   Toppo, E
   Pandikumar, P
   Ignacimuthu, S
   Al-Dhabi, NA
AF Govindaraj, Ramar
   Paulraj, Michael Gabriel
   Toppo, Erenius
   Pandikumar, Perumal
   Ignacimuthu, Savarimuthu
   Al-Dhabi, Naif Abdhullah
TI Hepatoprotective Effect of Tricholoma giganteum (Agaricomycetes)
   in a Nonalcoholic Fatty Liver Disease Rat Model
SO INTERNATIONAL JOURNAL OF MEDICINAL MUSHROOMS
LA English
DT Article
DE medicinal mushrooms; metabolic syndrome; natural products; Tricholoma
   giganteum
ID OXIDATIVE STRESS; ANIMAL-MODELS
AB Different concentrations of standardized ethanolic extract from the basidiocarps of Tricholoma giganteum Massee (TgEtOH) were screened for hepatoprotective effects in an animal model of rats with nonalcoholic fatty liver disease (NAFLD) fed a high-fat and high-fructose diet. After 4 weeks of treatment with TgEtOH, the relative liver weights, serum lipid concentrations, and biochemical profiles were found to be normal in treated animals compared with those given a standard drug. The macroscopic and histopathological studies clearly indicated that 200 mg/kg of ethanolic extract was effective in ameliorating the abnormalities of NAFLD. The findings indicate the efficacy of T. giganteum extract in liver protection. Future experiments on bioassay tailored fractionation of TgEtOH and mechanistic-based evaluation are required to assess the potential application of this mushroom as a food supplement in NAFLD.
C1 [Govindaraj, Ramar; Paulraj, Michael Gabriel; Toppo, Erenius; Pandikumar, Perumal; Ignacimuthu, Savarimuthu] Loyola Coll, Entomol Res Inst, Div Ethnopharmacol, Madras, Tamil Nadu, India.
   [Ignacimuthu, Savarimuthu] King Saud Univ, Coll Sci, Int Sci Partnership, Riyadh, Saudi Arabia.
   [Al-Dhabi, Naif Abdhullah] King Saud Univ, Dept Bot & Microbiol, Coll Sci, Riyadh, Saudi Arabia.
C3 Loyola College - Chennai; King Saud University; King Saud University
RP Pandikumar, P; Ignacimuthu, S (corresponding author), Loyola Coll, Entomol Res Inst, Madras 600034, Tamil Nadu, India.
EM eriloyola@hotmail.com
RI Al-Dhabi, Naif/E-7305-2014; Pandikumar, P./I-6144-2019; Ignacimuthu,
   S/ABH-3983-2020
OI Gabriel Paulraj, Michael/0000-0003-3348-223X; Ignacimuthu,
   S/0000-0002-8467-789X; Pandikumar, Perumal/0000-0002-1643-7325
FU Loyola College-Times of India [7LCTOIERI004]; King Saud University
FX The authors thank Loyola College-Times of India (research grant sanction
   no. 7LCTOIERI004) for financial support. We also thank Vice Deanship of
   Research Chairs, King Saud University.
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NR 34
TC 7
Z9 9
U1 0
U2 11
PU BEGELL HOUSE INC
PI DANBURY
PA 50 NORTH ST, DANBURY, CT 06810 USA
SN 1521-9437
EI 1940-4344
J9 INT J MED MUSHROOMS
JI Int. J. Med. Mushrooms
PY 2016
VL 18
IS 8
BP 661
EP 669
DI 10.1615/IntJMedMushrooms.v18.i8.20
PG 9
WC Biochemistry & Molecular Biology; Plant Sciences; Mycology; Pharmacology
   & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Plant Sciences; Mycology; Pharmacology
   & Pharmacy
GA ED5ZN
UT WOS:000388933100002
PM 27910784
DA 2025-06-11
ER

PT J
AU Itabe, H
   Ueda, M
AF Itabe, Hiroyuki
   Ueda, Makiko
TI Measurement of plasma oxidized low-density lipoprotein and its clinical
   implications
SO JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
LA English
DT Review
DE oxidized low-density lipoprotein; ELISA; monoclonal antibody; AMI
ID CORONARY-ARTERY-DISEASE; MACROPHAGE SCAVENGER RECEPTORS; ACUTE
   MYOCARDIAL-INFARCTION; ACUTE CEREBRAL INFARCTION; BIOCHEMICAL RISK
   MARKER; MONOCLONAL-ANTIBODY; PLAQUE INSTABILITY; METABOLIC SYNDROME;
   OXIDATIVE STRESS; HEART-DISEASE
AB Oxidized low-density lipoprotein (OxLDL) has been shown to exist in human circulating plasma. Several groups including ours have developed methods for immunologically measuring OxLDL, which have been applied to several clinical, both cross-sectional and prospective, studies. These data clearly show that OxLDL levels correlate well with the severity of cardiovascular diseases. In particular, recent observations suggest that plasma OxLDL levels could be a useful marker for predicting future cardiovascular events; however, substantial differences exist among the different methods of OxLDL measurement. To evaluate the clinical data on circulating OxLDL, a proper understanding of the similarity, differences, and limitation of the methods is needed. This paper summarizes the characteristics of the methods used and recent clinical findings.
C1 Showa Univ, Sch Pharmaceut Sci, Dept Biol Chem, Shinagawa Ku, Tokyo 1428555, Japan.
   Osaka City Univ, Grad Sch Med, Dept Pathol, Osaka, Japan.
C3 Showa University; Osaka Metropolitan University
RP Itabe, H (corresponding author), Showa Univ, Sch Pharmaceut Sci, Dept Biol Chem, Shinagawa Ku, 1-5-8 Hatanodai, Tokyo 1428555, Japan.
EM h-itabe@pharm.showa-u.ac.jp
RI 板部板部, 洋之/ABC-7746-2020
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NR 58
TC 128
Z9 144
U1 1
U2 11
PU JAPAN ATHEROSCLEROSIS SOC
PI TOKYO
PA NICHINAI-KAIKAN B1, 3-28-8 HONGO BUNKYO-KU, TOKYO, 113-0033, JAPAN
SN 1340-3478
EI 1880-3873
J9 J ATHEROSCLER THROMB
JI J. Atheroscler. Thromb.
PD FEB
PY 2007
VL 14
IS 1
BP 1
EP 11
DI 10.5551/jat.14.1
PG 11
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 141MG
UT WOS:000244582200001
PM 17332686
OA hybrid
DA 2025-06-11
ER

PT J
AU Shi, YJ
   Perez-Bonilla, P
   Chen, X
   Tam, K
   Marshall, M
   Morin, J
   Laviolette, B
   Kue, NR
   Damilano, F
   Miller, RA
   Zhang, BB
   Flach, RJR
   Hirenallur-Shanthappa, D
AF Shi, Yuji
   Perez-Bonilla, Patricia
   Chen, Xian
   Tam, Kelly
   Marshall, Mackenzie
   Morin, Jeffrey
   Laviolette, Brianna
   Kue, Nouaying R.
   Damilano, Federico
   Miller, Russell A.
   Zhang, Bei B.
   Roth Flach, Rachel J.
   Hirenallur-Shanthappa, Dinesh
TI Metabolic Syndrome Nonalcoholic Steatohepatitis Male Mouse With
   Adeno-Associated Viral Renin as a Novel Model for Heart Failure With
   Preserved Ejection Fraction
SO JOURNAL OF THE AMERICAN HEART ASSOCIATION
LA English
DT Article
DE cardiometabolism; empagliflozin; HFpEF; mouse models; MSNASH; renin;
   sacubitril/valsartan
ID AKR-J MICE; SKELETAL-MUSCLE; ANGIOTENSIN SYSTEM; EXERCISE INTOLERANCE;
   LYMPHOCYTE POPULATIONS; DIASTOLIC FUNCTION; INBRED STRAINS; OLDER
   PATIENTS; C57BL/6J MICE; HYPERTENSION
AB Background Heart failure with preserved ejection fraction (HFpEF) currently accounts for more than half of patients with HF, with limited approved evidence-based therapies. HFpEF is a complex multifactorial disease associated with hypertension, obesity, diabetes, and renal dysfunction. In addition to our limited understanding of HFpEF pathophysiology, the development of new therapies is partially hindered by the existing translationally relevant preclinical HFpEF models.Methods and Results Here, we report the development of a novel 2-hit HFpEF male mouse model through adding hypertensive stress from the activation of the renin-angiotensin-aldosterone system with adeno-associated viral-renin (AAV-renin), to the metabolic syndrome nonalcoholic steatohepatitis (MSNASH, formerly FATZO) mouse (MSNASH+AAV-renin). To further demonstrate model translatability, MSNASH+AAV-renin mice were then treated with approved HFpEF therapies sacubitril/valsartan or a combination of sacubitril/valsartan and empagliflozin. We found that the MSNASH+AAV-renin mouse model demonstrates clinically relevant features of human HFpEF, including preserved ejection fraction, cardiac hypertrophy, left atrial enlargement, diastolic dysfunction, elevated natriuretic peptides, inflammation, and low exercise capacity. We also demonstrate that treatment with approved HFpEF therapies sacubitril/valsartan and the combination of sacubitril/valsartan with empagliflozin improves the cardiac phenotypes of HFpEF in this model.Conclusions The MSNASH+AAV-renin model faithfully represents a severe cardiometabolic HFpEF phenogroup that can be used as a new tool for HFpEF preclinical research and drug discovery.
C1 [Shi, Yuji; Tam, Kelly; Marshall, Mackenzie; Kue, Nouaying R.; Damilano, Federico; Miller, Russell A.; Zhang, Bei B.; Roth Flach, Rachel J.] Internal Med Res Unit, Cambridge, MA USA.
   [Perez-Bonilla, Patricia; Chen, Xian; Morin, Jeffrey; Laviolette, Brianna; Hirenallur-Shanthappa, Dinesh] Global Discovery Invest & Translat Sci Anim Models, Cambridge, MA USA.
   [Shi, Yuji; Perez-Bonilla, Patricia; Chen, Xian; Tam, Kelly; Marshall, Mackenzie; Morin, Jeffrey; Laviolette, Brianna; Kue, Nouaying R.; Damilano, Federico; Miller, Russell A.; Zhang, Bei B.; Roth Flach, Rachel J.; Hirenallur-Shanthappa, Dinesh] Pfizer Inc, 1 Portland St, Cambridge, MA 02139 USA.
C3 Pfizer; Pfizer USA
RP Hirenallur-Shanthappa, D (corresponding author), Pfizer Inc, 1 Portland St, Cambridge, MA 02139 USA.
EM dineshh@pfizer.com
RI Shi, Yuji/JHX-3965-2023
OI Morin, Jeffrey/0000-0002-1656-296X; Miller, Russell/0000-0003-0268-1391;
   Chen, Xian/0009-0003-4162-6384
FU Pfizer Inc; Pfizer comparative medicine unit
FX We thank the Pfizer comparative medicine unit for their support of
   animal husbandry. We also thank Dr Daniel Kelly and Dr John Groarke for
   their advice. Lastly, we thank the Jackson Laboratory for providing n=20
   MSNASH mice for the initial evaluation work.
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NR 112
TC 0
Z9 0
U1 4
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
EI 2047-9980
J9 J AM HEART ASSOC
JI J. Am. Heart Assoc.
PD DEC 3
PY 2024
VL 13
IS 23
AR e035894
DI 10.1161/JAHA.124.035894
PG 21
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA O0P8T
UT WOS:001368258900001
PM 39575718
DA 2025-06-11
ER

PT J
AU Nichenametla, SN
   Mattocks, DAL
   Cooke, D
   Midya, V
   Malloy, VL
   Mansilla, W
   Ovrebo, B
   Turner, C
   Bastani, NE
   Sokolová, J
   Pavlíková, M
   Richie, JP 
   Shoveller, AK
   Refsum, H
   Olsen, T
   Vinknes, KJ
   Kozich, V
   Ables, GP
AF Nichenametla, Sailendra N.
   Mattocks, Dwight A. L.
   Cooke, Diana
   Midya, Vishal
   Malloy, Virginia L.
   Mansilla, Wilfredo
   Ovrebo, Bente
   Turner, Cheryl
   Bastani, Nasser E.
   Sokolova, Jitka
   Pavlikova, Marketa
   Richie, John P., Jr.
   Shoveller, Anna K.
   Refsum, Helga
   Olsen, Thomas
   Vinknes, Kathrine J.
   Kozich, Viktor
   Ables, Gene P.
TI Cysteine restriction-specific effects of sulfur amino acid restriction
   on lipid metabolism
SO AGING CELL
LA English
DT Article
DE aging; caloric restriction; cysteine; metabolic syndrome; methionine;
   nutrition; sulfur amino acids; triglycerides
ID DIETARY METHIONINE RESTRICTION; IN-VIVO; PROTEIN-SYNTHESIS;
   STRESS-RESPONSE; HOMOCYSTEINE; SERINE; CYSTINE; PLASMA; PHOSPHORYLATION;
   SUPPLEMENTATION
AB Decreasing the dietary intake of methionine exerts robust anti-adiposity effects in rodents but modest effects in humans. Since cysteine can be synthesized from methionine, animal diets are formulated by decreasing methionine and eliminating cysteine. Such diets exert both methionine restriction (MR) and cysteine restriction (CR), that is, sulfur amino acid restriction (SAAR). Contrarily, SAAR diets formulated for human consumption included cysteine, and thus might have exerted only MR. Epidemiological studies positively correlate body adiposity with plasma cysteine but not methionine, suggesting that CR, but not MR, is responsible for the anti-adiposity effects of SAAR. Whether this is true, and, if so, the underlying mechanisms are unknown. Using methionine- and cysteine-titrated diets, we demonstrate that the antiadiposity effects of SAAR are due to CR. Data indicate that CR increases serinogenesis (serine biosynthesis from non-glucose substrates) by diverting substrates from glyceroneogenesis, which is essential for fatty acid reesterification and triglyceride synthesis. Molecular data suggest that CR depletes hepatic glutathione and induces Nrf2 and its downstream targets Phgdh (the serine biosynthetic enzyme) and Pepck-M. In mice, the magnitude of SAAR-induced changes in molecular markers depended on dietary fat concentration (60% fat >10% fat), sex (males> females), and age-at-onset (young> adult). Our findings are translationally relevant as we found negative and positive correlations of plasma serine and cysteine, respectively, with triglycerides and metabolic syndrome criteria in a cross-sectional epidemiological study. Controlled feeding of low-SAA, high-polyunsaturated fatty acid diets increased plasma serine in humans. Serinogenesis might be a target for treating hypertriglyceridemia.
C1 [Nichenametla, Sailendra N.; Mattocks, Dwight A. L.; Cooke, Diana; Malloy, Virginia L.; Ables, Gene P.] Orentreich Fdn Adv Sci, Anim Sci Lab, Cold Spring On Hudson, NY USA.
   [Midya, Vishal] Icahn Sch Med Mt Sinai, Dept Environm Med & Publ Hlth, New York, NY 10029 USA.
   [Mansilla, Wilfredo; Shoveller, Anna K.] Univ Guelph, Dept Anim Biosci, Guelph, ON, Canada.
   [Ovrebo, Bente; Bastani, Nasser E.; Refsum, Helga; Olsen, Thomas; Vinknes, Kathrine J.] Univ Oslo, Inst Basic Med Sci, Dept Nutr, Oslo, Norway.
   [Turner, Cheryl; Refsum, Helga] Univ Oxford, Dept Pharmacol, Oxford, England.
   [Sokolova, Jitka; Kozich, Viktor] Charles Univ Prague, Gen Univ Hosp Prague, Fac Med 1, Dept Pediat & Inherited Metab Disorders, Prague, Czech Republic.
   [Pavlikova, Marketa] Charles Univ Prague, Fac Math & Phys, Dept Probabil & Math Stat, Prague, Czech Republic.
   [Richie, John P., Jr.] Penn State Univ, Dept Publ Hlth Sci & Pharmacol, Coll Med, Hershey, PA USA.
C3 Icahn School of Medicine at Mount Sinai; University of Guelph;
   University of Oslo; University of Oxford; Charles University Prague;
   General University Hospital Prague; Charles University Prague;
   Pennsylvania Commonwealth System of Higher Education (PCSHE);
   Pennsylvania State University; Penn State Health
RP Nichenametla, SN (corresponding author), Orentreich Fdn Adv Sci, 855 Route 301, Cold Spring on Hudson, NY 10516 USA.
EM snichenametla@orentreich.org
RI Olsen, Thomas/P-1400-2019; Nichenametla, Sailendra Nath/B-2733-2009;
   Kozich, Viktor/A-7672-2008; Vinknes, Kathrine/I-3979-2017; Pavlikova,
   Marketa/F-4563-2016; Midya, Vishal/KBR-2707-2024; Sokolova,
   Jitka/H-9924-2015
OI Nichenametla, Sailendra Nath/0000-0002-5969-3572; Kozich,
   Viktor/0000-0001-5820-5277; Ables, Gene/0000-0002-8238-0726; Vinknes,
   Kathrine/0000-0002-0756-5042; Pavlikova, Marketa/0000-0003-4314-4357;
   Olsen, Thomas/0000-0003-1805-5221; Midya, Vishal/0000-0002-6643-5176;
   Sokolova, Jitka/0000-0002-0453-3336
FU Ministerstvo Zdravotnictvi Ceske Republiky [RVO-VFN 64165]; National
   Institute of Environmental Health Sciences [P30ES023515]; Norges
   Forskningsrad [ES528805]; Orentreich Foundation for the Advancement of
   Science [ASL18, ASL32, ASL21, ASL24]
FX Ministerstvo Zdravotnictvi Ceske Republiky, Grant/Award Number: RVO-VFN
   64165; National Institute of Environmental Health Sciences, Grant/Award
   Number: P30ES023515; Norges Forskningsrad, Grant/Award Number: ES528805;
   Orentreich Foundation for the Advancement of Science, Grant/Award
   Number: ASL18, ASL32, ASL21 and ASL24
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NR 68
TC 11
Z9 11
U1 4
U2 19
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1474-9718
EI 1474-9726
J9 AGING CELL
JI Aging Cell
PD DEC
PY 2022
VL 21
IS 12
AR e13739
DI 10.1111/acel.13739
EA NOV 2022
PG 17
WC Cell Biology; Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Geriatrics & Gerontology
GA 7F4KW
UT WOS:000888773900001
PM 36403077
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Yamazaki, M
   Yamada, H
   Munetsuna, E
   Maeda, K
   Ando, Y
   Mizuno, G
   Fujii, R
   Tsuboi, Y
   Ohashi, K
   Ishikawa, H
   Hashimoto, S
   Hamajima, N
   Suzuki, K
AF Yamazaki, Mirai
   Yamada, Hiroya
   Munetsuna, Eiji
   Maeda, Keisuke
   Ando, Yoshitaka
   Mizuno, Genki
   Fujii, Ryosuke
   Tsuboi, Yoshiki
   Ohashi, Koji
   Ishikawa, Hiroaki
   Hashimoto, Shuji
   Hamajima, Nobuyuki
   Suzuki, Koji
TI DNA methylation level of the gene encoding thioredoxin-interacting
   protein in peripheral blood cells is associated with metabolic syndrome
   in the Japanese general population
SO ENDOCRINE JOURNAL
LA English
DT Article
DE Metabolic disorder; Obesity; Thioredoxin-interacting protein (TXNIP);
   DNA methylation; Pyrosequencing
ID EPIGENOME-WIDE ASSOCIATION; DIETARY-FAT INTAKE; OXIDATIVE STRESS;
   INFLAMMATION; TXNIP; RISK; ARTERIOSCLEROSIS; DYSFUNCTION; DISEASE; LOCI
AB Metabolic syndrome (MetS) is cluster of metabolic diseases, including abdominal obesity, hyperglycemia, high blood pressure, and dyslipidemia, that directly escalate the risk of type 2 diabetes, heart disease, and stroke. Thioredoxin-interacting protein (TXNIP) is a binding protein for thioredoxin, a molecule that is a key inhibitor of cellular oxidation, and thus regulates the cellular redox state. Epigenetic alteration of the TXNIP-encoding locus has been associated with components of MetS. In the present study, we sought to determine whether the level of TXNIP methylation in blood is associated with MetS in the general Japanese population. DNA was extracted from the peripheral blood cells of 37 subjects with and 392 subjects without MetS. The level of TXNIP methylation at cg19693031 was assessed by the bisulfite-pyrosequencing method. We observed that TXNIP methylation levels were lower in MetS subjects (median 74.9%, range 71.7-78.4%) than in non-MetS subjects (median 77.7%, range 74.4-80.5%; p = 0.0024). Calculation of the confounding factor-adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for hypomethylation revealed that subjects with MetS exhibited significantly higher ORs for hypomethylation than did those without MetS (OR, 2.92; 95% CI, 1.33-6.62; p = 0.009). Our findings indicated that lower levels of TXNIP methylation are associated with MetS in the general Japanese population. Altered levels of DNA methylation in TXNIP at cg19693031 might play an important role in the pathogenesis of MetS.
C1 [Yamazaki, Mirai] Kagawa Prefectural Univ Hlth Sci, Dept Med Technol, Takamatsu, Kagawa 7610123, Japan.
   [Yamada, Hiroya; Hashimoto, Shuji] Fujita Hlth Univ, Dept Hyg, Sch Med, Toyoake, Aichi 4701192, Japan.
   [Munetsuna, Eiji] Fujita Hlth Univ, Sch Med, Dept Biochem, Toyoake, Aichi 4701192, Japan.
   [Maeda, Keisuke] Fujita Hlth Univ, Dept Clin Physiol, Sch Med Sci, Toyoake, Aichi 4701192, Japan.
   [Ando, Yoshitaka; Ohashi, Koji; Ishikawa, Hiroaki] Fujita Hlth Univ, Dept Biomed & Analyt Sci, Sch Med Sci, Toyoake, Aichi 4701192, Japan.
   [Mizuno, Genki] Fujita Hlth Univ, Dept Joint Res Lab Clin Med, Sch Med Sci, Toyoake, Aichi 4701192, Japan.
   [Fujii, Ryosuke; Tsuboi, Yoshiki; Suzuki, Koji] Fujita Hlth Univ, Dept Prevent Med Sci, Sch Med Sci, 1-98 Dengakugakubo,Kutsukake cho, Toyoake, Aichi 4701192, Japan.
   [Hamajima, Nobuyuki] Nagoya Univ, Dept Healthcare Adm, Grad Sch Med, Nagoya, Aichi 4668550, Japan.
C3 Fujita Health University; Fujita Health University; Fujita Health
   University; Fujita Health University; Fujita Health University; Fujita
   Health University; Nagoya University
RP Suzuki, K (corresponding author), Fujita Hlth Univ, Dept Prevent Med Sci, Sch Med Sci, 1-98 Dengakugakubo,Kutsukake cho, Toyoake, Aichi 4701192, Japan.
EM ksuzuki@fujita-hu.ac.jp
RI Hamajima, Nobuyuki/I-7237-2014; Maeda, Keisuke/KCY-9229-2024
OI Tsuboi, Yoshiki/0000-0001-8145-3949; Mizuno, Genki/0000-0001-8052-5146
FU Japan Society for the Promotion of Science (JSPS) [JP26293144,
   JP17K09139, JP16H06277, JP19K24172, JP20K10515]
FX We thank the participants and staff of the Health Examination Program
   for Residents of Yakumo, Hokkaido, Japan. This work was supported by the
   Japan Society for the Promotion of Science (JSPS) under Grants-in-Aid
   for Scientific Research Nos. JP26293144, JP17K09139, JP16H06277,
   JP19K24172, and JP20K10515.
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NR 54
TC 10
Z9 10
U1 0
U2 4
PU JAPAN ENDOCRINE SOC
PI KYOTO
PA 75  YANAGINOBANBA NISHIIRU-MASUYA-CHO, SANJOU-DORI, NAKAGYOU-KU, KYOTO,
   604-8111, JAPAN
SN 0918-8959
EI 1348-4540
J9 ENDOCR J
JI Endocr. J.
PY 2022
VL 69
IS 3
BP 319
EP 326
DI 10.1507/endocrj.EJ21-0339
EA OCT 2021
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 0U6KQ
UT WOS:000736193300001
PM 34645728
OA gold
DA 2025-06-11
ER

PT J
AU Martinez, R
   Kapravelou, G
   Donaire, A
   Lopez-Chaves, C
   Arrebola, F
   Galisteo, M
   Cantarero, S
   Aranda, P
   Porres, JM
   López-Jurado, M
AF Martinez, Rosario
   Kapravelou, Garyfallia
   Donaire, Ana
   Lopez-Chaves, Carlos
   Arrebola, Francisco
   Galisteo, Milagros
   Cantarero, Samuel
   Aranda, Pilar
   Porres, Jesus M.
   Lopez-Jurado, Maria
TI Effects of a combined intervention with a lentil protein hydrolysate and
   a mixed training protocol on the lipid metabolism and hepatic markers of
   NAFLD in Zucker rats
SO FOOD & FUNCTION
LA English
DT Article
ID FATTY LIVER-DISEASE; OXIDATIVE STRESS; PHYSICAL-ACTIVITY;
   ANIMAL-TISSUES; FA/FA RATS; EXERCISE; ANTIOXIDANT; INTENSITY; DIET;
   INFLAMMATION
AB Metabolic syndrome is a cluster of metabolic alterations characterized by central obesity, dyslipidemia, elevated plasma glucose, insulin resistance (IR) and non-alcoholic fatty liver disease (NAFLD). In this study, a combined intervention of a lentil protein hydrolysate and a mixed training protocol was assessed in an animal experimental model of genetic obesity and metabolic syndrome. Thirty-two male obese and 32 lean Zucker rats were divided into eight different experimental groups. Rats performed a mixed exercise protocol or had a sedentary lifestyle and were administered a lentil protein hydrolysate or placebo. Daily food intake, weekly body weight gain, plasma parameters of glucose and lipid metabolisms, body composition, hepatic weight, total fat content and fatty acid profile, as well as gene expression of lipogenic and lipolytic nuclear transcription factors and their target genes were measured. Obese Zucker rats exhibited higher body and liver weight and fat content than did their lean counterparts. Such alterations were related to modifications in aerobic capacity, plasma biochemical parameters of glucose and lipid metabolisms, hepatic fatty acid profile and gene expression of nuclear transcription factors SREBP1c, PPAR alpha, LXR and associated lipogenic and lipolytic enzymes. The interventions tested did not affect body weight gain but improved aerobic capacity, reduced hepatomegalia and steatosis associated with NAFLD and relieved the adverse effects produced by this condition in glucose and lipid metabolisms through the modulation in the expression of different genes involved in diverse metabolic pathways.
C1 [Martinez, Rosario; Kapravelou, Garyfallia; Donaire, Ana; Lopez-Chaves, Carlos; Aranda, Pilar; Porres, Jesus M.; Lopez-Jurado, Maria] Univ Granada, Sport & Hlth Res Ctr, Ctr Biomed Res, Dept Physiol,Inst Nutr & Food Technol, Granada, Spain.
   [Arrebola, Francisco] Univ Granada, Ctr Biomed Res, Inst Neurosci, Dept Histol, Granada, Spain.
   [Galisteo, Milagros] Univ Granada, Dept Pharmacol, Sch Pharm, Campus Univ Cartuja S-N, E-18071 Granada, Spain.
   [Cantarero, Samuel] Univ Granada, Ctr Instrumentac Cient, Campus Univ Fuentenueva S-N, E-18071 Granada, Spain.
C3 University of Granada; University of Granada; University of Granada;
   University of Granada
RP Porres, JM (corresponding author), Univ Granada, Sport & Hlth Res Ctr, Ctr Biomed Res, Dept Physiol,Inst Nutr & Food Technol, Granada, Spain.
EM rosariomz@ugr.es; gkapravelou@gmail.com; anadonb@gmail.com;
   carloschaves@ugr.es; paranda@ugr.es; jmporres@ugr.es; mlopezj@ugr.es
RI Kapravelou, Garyfallia/K-8635-2017; Arrebola Vargas,
   Francisco/L-9108-2014; Cantarero Malagon, Antonio Samuel/C-3258-2017;
   Porres Foulquie, Jesus Maria/B-6442-2018; Martinez, Rosario/K-7712-2017;
   Aranda Ramirez, Pilar/B-8037-2016
OI Cantarero Malagon, Antonio Samuel/0000-0002-3716-0070; Porres Foulquie,
   Jesus Maria/0000-0001-5657-0764; Galisteo Moya,
   Milagros/0000-0001-7656-5989; Martinez, Rosario/0000-0003-2032-1621;
   Aranda Ramirez, Pilar/0000-0002-7982-1359
FU European Union [AGL2013-43247-R, DEP2014-58296-R]
FX The authors want to acknowledge the Ministry of Economy and
   Competitiveness (MINECO, Spain) and the European Union through projects
   AGL2013-43247-R and DEP2014-58296-R, and the FEDER program,
   respectively. The funders had no role in study design, data collection
   and analysis, decision to publish, or preparation of the manuscript. The
   special contribution to the development of the experiments and
   characterization of the protein hydrolysate by the Experimental Animal
   Unit and the Analysis and Structure Detection Unit of CIC (University of
   Granada) is also acknowledged.
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NR 65
TC 23
Z9 24
U1 0
U2 42
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PD FEB
PY 2018
VL 9
IS 2
BP 830
EP 850
DI 10.1039/c7fo01790a
PG 21
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA GC6GB
UT WOS:000429887000012
PM 29364302
DA 2025-06-11
ER

PT J
AU López-Acosta, O
   Fortis-Barrera, MD
   Barrios-Maya, MA
   Ramírez, AR
   Aguilar, FJA
   El-Hafidi, M
AF Lopez-Acosta, Ocarol
   de los Angeles Fortis-Barrera, Maria
   Angel Barrios-Maya, Miguel
   Ruiz Ramirez, Angelica
   Alarcon Aguilar, Francisco Javier
   El-Hafidi, Mohammed
TI Reactive Oxygen Species from NADPH Oxidase and Mitochondria Participate
   in the Proliferation of Aortic Smooth Muscle Cells from a Model of
   Metabolic Syndrome
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Article
ID OXIDATIVE STRESS; INSULIN-RESISTANCE; HYDROGEN-PEROXIDE; CYCLOPHILIN;
   PURIFICATION; INFLAMMATION; SUPEROXIDE; QUANTITIES; GENERATION; APOCYNIN
AB In metabolic diseases, the increased reactive oxygen species (ROS) represents one of the pathogenic mechanisms for vascular disease probably by promoting vascular smooth muscle cell (SMC) proliferation that contributes to the development of arterial remodeling and stenosis, hypertension, and atherosclerosis. Therefore, this work was undertaken to evaluate the participation of ROS from NADPH oxidase and mitochondria in the proliferation of SMCs from the aorta in a model of metabolic syndrome induced by sucrose feeding in rats. After 24 weeks, sucrose-fed (SF) rats develop hypertension, intra-abdominal obesity, hyperinsulinemia, and hyperleptinemia. In addition SMCs from SF rats had a higher growth rate and produce more ROS than control cells. The treatment of SMCs with DPI and apocynin to inhibit NADPH oxidase and with tempol to scavenge superoxide anion significantly blocked the proliferation of both SF and control cells suggesting the participation of NADPH oxidase as a source of superoxide anion. MitoTEMPO, which targets mitochondria within the cell, also significantly inhibited the proliferation of SMCs having a greater effect on cells from SF than from the control aorta. The higher rate of cell growth from the SF aorta is supported by the increased content of cyclophilin A and CD147, proteins involved in the mechanism of cell proliferation. In addition, caldesmon, alpha-actin, and phosphorylated myosin light chain, contractile phenotype proteins, were found significantly lower in SF cells in no confluent state and increased in confluent state but without difference between both cell types. Our results suggest that ROS from NADPH oxidase and mitochondria significantly participate in the difference found in the rate of cell growth between SF and control cells.
C1 [Lopez-Acosta, Ocarol] Univ Autonoma Metropolitana, Unidad Iztapalapa, Ciencias Biol & Salud, Ave San Rafael Atlixco 186, Ciudad De Mexico 09340, Mexico.
   [Lopez-Acosta, Ocarol; Angel Barrios-Maya, Miguel; Ruiz Ramirez, Angelica; El-Hafidi, Mohammed] Inst Nacl Cardiol Ignacio Chavez, Dept Biomed Cardiovasc, Juan Badiano 1,Colonia Secc 16, Ciudad De Mexico 14080, Mexico.
   [de los Angeles Fortis-Barrera, Maria; Alarcon Aguilar, Francisco Javier] Univ Autonoma Metropolitana, Unidad Iztapalapa, Lab Farmacol, Dept Ciencias Salud, Ave San Rafael Atlixco 186, Ciudad De Mexico 09340, Mexico.
C3 Universidad Autonoma Metropolitana - Mexico; National Institute of
   Cardiology - Mexico; Universidad Autonoma Metropolitana - Mexico
RP El-Hafidi, M (corresponding author), Inst Nacl Cardiol Ignacio Chavez, Dept Biomed Cardiovasc, Juan Badiano 1,Colonia Secc 16, Ciudad De Mexico 14080, Mexico.
EM medelhafidi@yahoo.com
RI El-Hafidi, Mohammed/AAN-4083-2021
OI Fortis-Barrera, Angeles/0000-0003-0923-501X
FU CONACYT through the Doctorate in Biological Sciences and Health of the
   Metropolitan Autonomous University, Iztapalapa (UAM-I) [284105]; CONACYT
   [185450]; Institute of Science and Technology of the Federal District,
   Mexico City (ICyTDF), Mexico [PICDS08-67]
FX This study was supported by the CONACYT (scholarship no. 284105 to
   Ocarol Lopez Acosta) through the Doctorate in Biological Sciences and
   Health of the Metropolitan Autonomous University, Iztapalapa (UAM-I).
   This work was also supported in part by CONACYT (Grant no. 185450) and
   by the Institute of Science and Technology of the Federal District,
   Mexico City (ICyTDF), Mexico (Grant no. PICDS08-67).
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NR 47
TC 22
Z9 23
U1 0
U2 5
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PY 2018
VL 2018
AR 5835072
DI 10.1155/2018/5835072
PG 10
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA HH3PI
UT WOS:000455631100001
PM 30671170
OA Green Published, hybrid, Green Submitted
DA 2025-06-11
ER

PT J
AU Chen, S
   Guo, XF
   Yu, SS
   Sun, GZ
   Yang, HM
   Li, Z
   Sun, YX
AF Chen, Shuang
   Guo, Xiaofan
   Yu, Shasha
   Sun, Guozhe
   Yang, Hongmei
   Li, Zhao
   Sun, Yingxian
TI Association between Serum Uric Acid and Elevated Alanine
   Aminotransferase in the General Population
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Article
DE alanine aminotransferase (ALT); hyperuricemia; serum alanine
   aminotransferase; serum uric acid
ID NONALCOHOLIC FATTY LIVER; METABOLIC SYNDROME; INSULIN-RESISTANCE;
   OXIDATIVE STRESS; CARDIOVASCULAR-DISEASE; KOREAN ADULTS; UNITED-STATES;
   RISK-FACTOR; ANTIOXIDANT; LEVEL
AB Background: Both the serum uric acid (SUA) level and elevated alanine aminotransferase (ALT) are related to metabolic syndrome. However, the association between SUA and elevated ALT has not been elucidated in the general population. The objective of this study was to investigate the association between SUA and elevated ALT in the general population of China; Methods: A total of 11,572 adults (35 years of age) participated in this survey. Elevated ALT was defined as >40 U/L. SUA 7.0 mg/dL in males or 6.0 mg/dL in females was defined as hyperuricemia. SUA within the reference range was divided into quartiles, and its associations with elevated ALT were evaluated by logistic regressions; Results: A total of 7.4% participants had elevated ALT. The prevalence of hyperuricemia was 14.9% in males and 7.3% in females. There was a significantly positive dose-response association between SUA levels and the prevalence of elevated ALT. After adjusting for potential confounders, a positive relationship for elevated ALT was observed in subjects with hyperuricemia (odds ratio [OR]: 2.032, 95% confidence interval [CI]: 1.443-2.861 for men; OR: 2.045, 95% CI: 1.221-3.425 for women, both p < 0.05). Within the reference range, the association between SUA and elevated ALT persisted in the fourth quartile (OR: 1.467, 95% CI: 1.063-2.025 for men; OR: 1.721, 95% CI: 1.146-2.585 for women, both p < 0.05); Conclusions: Our results indicated that an increased SUA level, even within the reference range, was independently associated with elevated ALT in Chinese adults.
C1 [Chen, Shuang; Guo, Xiaofan; Yu, Shasha; Sun, Guozhe; Yang, Hongmei; Li, Zhao; Sun, Yingxian] China Med Univ, Dept Cardiol, Affiliated Hosp 1, Shenyang 110000, Peoples R China.
C3 China Medical University
RP Sun, YX (corresponding author), China Med Univ, Dept Cardiol, Affiliated Hosp 1, Shenyang 110000, Peoples R China.
EM loscs@126.com; guoxiaofan1986@foxmail.com; yidasasa@foxmail.com;
   gzhsun66@163.com; eileen8222@163.com; meilichian@aliyun.com.cn;
   yxsun@cmu.edu.cn
RI Sun, Yingxian/KHT-6171-2024
OI Sun, Yingxian/0000-0002-1961-899X
FU National Science and Technology Support Program of China [2012BAJ18B02]
FX The authors thank Yonghong Zhang, Liying Xing and Guowei Pan for their
   assistance. This study was supported by grants from the "Twelfth
   Five-Year" project funds (National Science and Technology Support
   Program of China, Grant #2012BAJ18B02) that Yingxian Sun responsible for
   to enable the project's completion.
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NR 39
TC 8
Z9 12
U1 1
U2 9
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD SEP
PY 2016
VL 13
IS 9
AR 841
DI 10.3390/ijerph13090841
PG 11
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA DX9EG
UT WOS:000384695800005
PM 27563918
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Preitner, F
   Laverriere-Loss, A
   Metref, S
   Da Costa, A
   Moret, C
   Rotman, S
   Bazin, D
   Daudon, M
   Sandt, C
   Dessombz, A
   Thorens, B
AF Preitner, Frederic
   Laverriere-Loss, Alexandra
   Metref, Salima
   Da Costa, Anabela
   Moret, Catherine
   Rotman, Samuel
   Bazin, Dominique
   Daudon, Michel
   Sandt, Christophe
   Dessombz, Arnaud
   Thorens, Bernard
TI Urate-induced acute renal failure and chronic inflammation in
   liver-specific Glut9 knockout mice
SO AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
LA English
DT Article
DE SLC2A9; glucose transporter 9; urate; crystal; acute renal failure;
   sterile inflammation
ID URIC-ACID NEPHROPATHY; INDEPENDENT MECHANISM; METABOLIC SYNDROME;
   DEFICIENT MICE; BLOOD-PRESSURE; PLASMA URATE; HYPERURICEMIA; DISEASE;
   RISK; SLC2A9
AB Plasma urate levels are higher in humans than rodents (240-360 vs. similar to 30 mu M) because humans lack the liver enzyme uricase. High uricemia in humans may protect against oxidative stress, but hyperuricemia also associates with the metabolic syndrome, and urate and uric acid can crystallize to cause gout and renal dysfunctions. Thus, hyperuricemic animal models to study urate-induced pathologies are needed. We recently generated mice with liver-specific ablation of Glut9, a urate transporter providing access of urate to uricase (LG9KO mice). LG9KO mice had moderately high uricemia (similar to 120 mu M). To further increase their uricemia, here we gavaged LG9KO mice for 3 days with inosine, a urate precursor; this treatment was applied in both chow-and high-fat-fed mice. In chow-fed LG9KO mice, uricemia peaked at 300 mu M 2 h after the first gavage and normalized 24 h after the last gavage. In contrast, in high-fat-fed LG9KO mice, uricemia further rose to 500 mu M. Plasma creatinine strongly increased, indicating acute renal failure. Kidneys showed tubule dilation, macrophage infiltration, and urate and uric acid crystals, associated with a more acidic urine. Six weeks after inosine gavage, plasma urate and creatinine had normalized. However, renal inflammation, fibrosis, and organ remodeling had developed despite the disappearance of urate and uric acid crystals. Thus, hyperuricemia and high-fat diet feeding combined to induce acute renal failure. Furthermore, a sterile inflammation caused by the initial crystal-induced lesions developed despite the disappearance of urate and uric acid crystals.
C1 [Preitner, Frederic; Laverriere-Loss, Alexandra; Metref, Salima; Da Costa, Anabela; Thorens, Bernard] Univ Lausanne Hosp, Cardiomet Ctr, Mouse Metab Facil, Lausanne, Switzerland.
   [Preitner, Frederic; Metref, Salima; Da Costa, Anabela; Moret, Catherine; Thorens, Bernard] Univ Lausanne, Ctr Integrat Genom, CH-1015 Lausanne, Switzerland.
   [Rotman, Samuel] Univ Lausanne, Mouse Pathol Facil, CH-1015 Lausanne, Switzerland.
   [Bazin, Dominique] Univ Paris 06, Coll France, Lab Chim Mat Condensee Paris, Paris, France.
   [Daudon, Michel] Hop Tenon, APHP, Serv Explorat Fonct, F-75970 Paris, France.
   [Sandt, Christophe] Synchrotron SOLEIL, LOrme Merisiers, Gif Sur Yvette, France.
   [Dessombz, Arnaud] Univ Paris 11, Phys Solides Lab, F-91405 Orsay, France.
C3 University of Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV);
   University of Lausanne; University of Lausanne; Universite PSL; Chimie
   ParisTech; College de France; Centre National de la Recherche
   Scientifique (CNRS); Sorbonne Universite; Assistance Publique Hopitaux
   Paris (APHP); Universite Paris Cite; Hopital Universitaire Hotel-Dieu -
   APHP; Sorbonne Universite; Hopital Universitaire Tenon - APHP; Hopital
   Universitaire Ambroise-Pare - APHP; SOLEIL Synchrotron; Universite Paris
   Saclay
RP Thorens, B (corresponding author), Univ Lausanne, Ctr Integrat Genom, Genopode Bldg, CH-1015 Lausanne, Switzerland.
EM Bernard.thorens@unil.ch
RI Sandt, Christophe/M-9806-2014; Dessombz, Arnaud/B-7149-2016; Bazin,
   Dominique/C-6306-2014
OI Dessombz, Arnaud/0000-0002-6610-4879; Rotman,
   Samuel/0000-0002-2508-3725; Bazin, Dominique/0000-0002-5112-9061
FU Swiss National Science Foundation [3100A0-113525]; EU 7th FP Integrated
   project EDICT [201924]; Swiss National Competence Center in Research
   Transcure
FX This work was supported by Swiss National Science Foundation Grant No.
   3100A0-113525 (B. Thorens), EU 7th FP Integrated project EDICT No.
   201924 (B. Thorens), and the Swiss National Competence Center in
   Research Transcure (B. Thorens).
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NR 42
TC 36
Z9 39
U1 1
U2 27
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 1931-857X
J9 AM J PHYSIOL-RENAL
JI Am. J. Physiol.-Renal Physiol.
PD SEP
PY 2013
VL 305
IS 5
BP F786
EP F795
DI 10.1152/ajprenal.00083.2013
PG 10
WC Physiology; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology; Urology & Nephrology
GA 214AA
UT WOS:000324101000020
PM 23804456
DA 2025-06-11
ER

PT J
AU Shannahan, JH
   Alzate, O
   Winnik, WM
   Andrews, D
   Schladweiler, MC
   Ghio, AJ
   Gavett, SH
   Kodavanti, UP
AF Shannahan, Jonathan H.
   Alzate, Oscar
   Winnik, Witold M.
   Andrews, Debora
   Schladweiler, Mette C.
   Ghio, Andrew J.
   Gavett, Stephen H.
   Kodavanti, Urmila P.
TI Acute phase response, inflammation and metabolic syndrome biomarkers of
   Libby asbestos exposure
SO TOXICOLOGY AND APPLIED PHARMACOLOGY
LA English
DT Article
DE Libby amphibole; Acute phase response; Serum proteomics; Biomarkers
ID INSULIN-RESISTANCE; OXIDATIVE STRESS; IRON OVERLOAD; AIR-POLLUTION; RAT
   MODELS; PULMONARY; OSTEOPONTIN; INHALATION; AMPHIBOLE; PLASMA
AB Identification of biomarkers assists in the diagnosis of disease and the assessment of health risks from environmental exposures. We hypothesized that rats exposed to Libby amphibole (LA) would present with a unique serum proteomic profile which could help elucidate epidemiologically-relevant biomarkers. In four experiments spanning varied protocols and temporality, healthy (Wistar Kyoto, WKY; and F344) and cardiovascular compromised (CVD) rat models (spontaneously hypertensive, SH: and SH heart failure. SHHF) were intratracheally instilled with saline (control) or LA. Serum biomarkers of cancer, inflammation, metabolic syndrome (MetS), and the acute phase response (APR) were analyzed. All rat strains exhibited acute increases in alpha-2-macroglobulin, and alpha 1-acid glycoprotein. Among markers of inflammation, lipocalin-2 was induced in WKY, SH and SHHF and osteopontin only in WKY after LA exposure. While rat strain- and age-related changes were apparent in MetS biomarkers, no LA effects were evident. The cancer marker mesothelin was increased only slightly at 1 month in WKY in one of the studies. Quantitative Intact Proteomic profiling of WKY serum at 1 day or 4 weeks after 4 weekly LA instillations indicated no oxidative protein modifications, however APR proteins were significantly increased. Those included serine protease inhibitor, apolipoprotein E, alpha-2-HS-glycoprotein, t-kininogen 1 and 2, ceruloplasmin, vitamin D binding protein, serum amyloid P, and more 1 day after last LA exposure. All changes were reversible after a short recovery regardless of the acute or long-term exposures. Thus. LA exposure induces an APR and systemic inflammatory biomarkers that could have implications in systemic and pulmonary disease in individuals exposed to LA. Published by Elsevier Inc.
C1 [Schladweiler, Mette C.; Gavett, Stephen H.; Kodavanti, Urmila P.] US EPA, Cardiopulm & Immunotoxicol Branch, Environm Publ Hlth Div, Natl Hlth & Environm Effects Res Lab,Off Res & De, Res Triangle Pk, NC 27711 USA.
   [Alzate, Oscar] Univ N Carolina, Sch Med, Syst Prote Ctr, Chapel Hill, NC 27599 USA.
   [Winnik, Witold M.; Andrews, Debora] US EPA, Res Core Unit, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
   [Ghio, Andrew J.] US EPA, Clin Res Branch, Environm Publ Hlth Div, Natl Hlth & Environm Effects Res Lab,Off Res & De, Chapel Hill, NC 27599 USA.
   [Shannahan, Jonathan H.] Univ N Carolina, Sch Med, Curriculum Toxicol, Chapel Hill, NC 27599 USA.
C3 United States Environmental Protection Agency; University of North
   Carolina School of Medicine; University of North Carolina; University of
   North Carolina Chapel Hill; United States Environmental Protection
   Agency; United States Environmental Protection Agency; University of
   North Carolina School of Medicine; University of North Carolina;
   University of North Carolina Chapel Hill
RP Kodavanti, UP (corresponding author), US EPA, Cardiopulm & Immunotoxicol Branch, Environm Publ Hlth Div, Natl Hlth & Environm Effects Res Lab,Off Res & De, B143-01, Res Triangle Pk, NC 27711 USA.
EM Kodavanti.Urmila@epa.gov
RI Alzate, Oscar/A-2533-2008
OI Alzate, Oscar/0000-0002-1083-2551
FU EPA/UNC, Curriculum in Toxicology, University of North Carolina
   [CR833237]
FX This work was supported in part by the EPA/UNC Toxicology Research
   Program, Training Agreement CR833237, Curriculum in Toxicology,
   University of North Carolina.
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NR 44
TC 17
Z9 18
U1 0
U2 11
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0041-008X
EI 1096-0333
J9 TOXICOL APPL PHARM
JI Toxicol. Appl. Pharmacol.
PD APR 15
PY 2012
VL 260
IS 2
BP 105
EP 114
DI 10.1016/j.taap.2012.02.006
PG 10
WC Pharmacology & Pharmacy; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Toxicology
GA 926HR
UT WOS:000302822400002
PM 22366155
DA 2025-06-11
ER

PT J
AU Giunta, G
   Iztueta, MF
   Cutine, P
   Helman, L
   Pirola, D
   Kraselnik, A
   Huerta, DA
   Acuna, MIR
   Brandani, L
AF Giunta, Gustavo
   Iztueta, Maria Florencia
   Cutine, Pablo
   Helman, Lorena
   Pirola, Daniel
   Kraselnik, Ariel
   Huerta, Daniel Antokoletz
   Acuna, Maria Isabel Rodriguez
   Brandani, Laura
TI Evaluation of the metabolic profile and prevalence of cardiovascular
   disease in former com- batants of the Malvinas war
SO MEDICINA-BUENOS AIRES
LA English
DT Article
DE cardiovascular risk; hypertension; diabetes mellitus; veterans;
   cardiovascular disease
ID POSTTRAUMATIC-STRESS-DISORDER; CORONARY-HEART-DISEASE; CHOLESTEROL
   EDUCATION-PROGRAM; HEALTH; VETERANS; RISK; ASSOCIATION; SYMPTOMS;
   OBESITY; ADULTS
AB Introduction: It has been reported in different parts of the world that war veterans are more exposed to cardio-vascular risk factors. The objective of this study was to establish the risk factors, the cardiometabolic profile and the prevalence of cardiovascular disease in a group of ex-combatants of the Malvinas War (HdeM). Methods: In a case-control design, data from 799 HdeM were analyzed and compared with 799 controls matched by age. The sample was selected from the participants of the Cardiovascular Health Prevention Program of the Favaloro Foundation, between January 2017 and December 2019. Results: The average age was 56.9 +/- 3.9 years. An increase in weight was observed among the HdeM (91.3 +/- 16.6 kg vs. 88.2 +/- 14.7 kg; p = 0.0001). A higher frequency of arterial hypertension (42% vs. 34%; p < 0.001) and diabetes mellitus (15.1% vs. 10.4%; p < 0.005) was observed in HdeM. Metabolic syndrome was also more prevalent in HdeM (49.2% vs. 39.7%; p = 0.0001). It was observed that the history of acute myocardial infarction was more frequent among the HdeM (3.6% vs. 2%; p < 0.05), with a similar prevalence of stroke (1.2% vs. 1%; p = ns), coronary angioplasty (3.2% vs. 2.1%; p = ns) or myocardial revascularization surgery (0.8% vs. 0.4%; p = ns). Discussion: The HdeM showed an increase in the frequency of risk factors, metabolic syndrome and acute myocardial infarction. It is important to take this increased risk into account in order to maximize cardiovascular prevention strategies in ex-combatants.
C1 [Giunta, Gustavo; Cutine, Pablo; Helman, Lorena; Pirola, Daniel; Kraselnik, Ariel; Huerta, Daniel Antokoletz] Fdn Favaloro, Unidad Metab, Secc Lipidos & Aterosclerosis, Buenos Aires, Argentina.
   [Iztueta, Maria Florencia] Fdn Favaloro, Serv Nutr, Buenos Aires, Argentina.
   [Acuna, Maria Isabel Rodriguez; Brandani, Laura] Fdn Favaloro, Prevenc Ctr Vida, Buenos Aires, Argentina.
   [Giunta, Gustavo] Hosp Univ, Fdn Favaloro, Ave Belgrano 1742, RA-1093 Buenos Aires, Argentina.
RP Giunta, G (corresponding author), Hosp Univ, Fdn Favaloro, Ave Belgrano 1742, RA-1093 Buenos Aires, Argentina.
EM ggiunta@ffavaloro.org
OI Kraselnik, Ariel/0000-0002-1788-0492
CR Alarcon C, 2016, DIABETES, V65, P438, DOI 10.2337/db15-0792
   Ballantyne CM, 2008, INT J OBESITY, V32, pS21, DOI 10.1038/ijo.2008.31
   Bedi US, 2007, J NATL MED ASSOC, V99, P642
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   US Department of Veterans Affairs, VET HLTH ADM CLOS 25
NR 31
TC 0
Z9 0
U1 0
U2 0
PU MEDICINA (BUENOS AIRES)
PI BUENOS AIRES
PA DONATO ALVAREZ 3150, 1427 BUENOS AIRES, ARGENTINA
SN 0025-7680
EI 1669-9106
J9 MEDICINA-BUENOS AIRE
JI Med.-Buenos Aires
PD OCT
PY 2022
VL 82
IS 5
BP 746
EP 751
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 9A4UK
UT WOS:000934054600019
PM 36220032
DA 2025-06-11
ER

PT J
AU Permatasari, HK
   Nurkolis, F
   Ben Gunawan, W
   Yusuf, VM
   Yusuf, M
   Kusuma, RJ
   Sabrina, N
   Muharram, FR
   Taslim, NA
   Mayulu, N
   Batubara, SC
   Samtiya, M
   Hardinsyah, H
   Tsopmo, A
AF Permatasari, Happy Kurnia
   Nurkolis, Fahrul
   Ben Gunawan, William
   Yusuf, Vincentius Mario
   Yusuf, Muhammad
   Kusuma, Rio Jati
   Sabrina, Nindy
   Muharram, Farizal Rizky
   Taslim, Nurpudji Astuti
   Mayulu, Nelly
   Batubara, Siti Chairiyah
   Samtiya, Mrinal
   Hardinsyah, Hardinsyah
   Tsopmo, Apollinaire
TI Modulation of gut microbiota and markers of metabolic syndrome in mice
   on cholesterol and fat enriched diet by butterfly pea flower kombucha
SO CURRENT RESEARCH IN FOOD SCIENCE
LA English
DT Article
DE Nutraceuticals; Metabolic syndrome; Kombucha; Clitoria ternatea; Lipid
   profile
ID OBESITY
AB Clitoria ternatea, with an alternative name, Butterfly pea, is increasingly being explored for medical purposes and the development of a wide range of processed products. This study aimed to incorporate Butterfly pea into an innovative probiotic drink through a symbiotic culture of bacteria and yeast (SCOBY) fermentation and to evaluate the biological activity. The benefits of the drink, referred to as butterfly pea flower kombucha (KBPF) was determined in vitro and in metabolically disorder mice that receive a diet rich in cholesterol and fat (CFED). Forty white male were categorized into four groups, i.e., A = Control/Normal Diet; B = CFED alone; C = CFED + KBPF 65 mg/kg BW (Body Weight); D = CFED + KBPF 130 mg/kg BW, and then sacrificed after 6 weeks of intervention. Seventy-nine secondary metabolite compounds were successfully identified in KBPF using LC-HRMS. In vitro studies showed the potential activity of KBPF in inhibiting not only ABTS, but also lipid (lipase) and carbohydrate (alpha-amylase, alpha-glucosidase) hydrolyzing enzymes to levels similar to acarbose control at 50-250 mu g/mL. In the in vivo study, the administration of KBPF (130 mg/kg BW) significantly alleviated metabolic disorders caused by high-fat diet. Specifically, lipid profile (HDL, LDL, TC, TG), blood glucose, markers of oxidative stress (SOD liver), metabolic enzymes (lipase, amylase), and markers of inflammation (PGC-1 alpha, TNF-alpha, and IL-10) were in most cases restored to normal values. Additionally, the gut microbiota community analysis showed that KBPF has a positive effect (p = 0.01) on both the Bacteroidetes phylum and the Firmicutes phylum. The new KBPF drink is a promising therapeutic functional food for preventing metabolic diseases.
C1 [Permatasari, Happy Kurnia] Brawijaya Univ, Fac Med, Biochem & Biomol, Malang 65145, Indonesia.
   [Nurkolis, Fahrul] State Islamic Univ Sunan Kalijaga UIN Sunan Kalija, Biol Sci, Yogyakarta 55281, Indonesia.
   [Ben Gunawan, William] Diponegoro Univ, Fac Med, Nutr Sci Dept, Semarang 50275, Central Java, Indonesia.
   [Yusuf, Vincentius Mario; Yusuf, Muhammad] Fac Med Univ Brawijaya, Med Programme, Malang 65145, Indonesia.
   [Kusuma, Rio Jati] Univ Gadjah Mada, Fac Med Publ Hlth & Nursing, Dept Nutr & Hlth, Yogyakarta 55223, Indonesia.
   [Sabrina, Nindy] Monash Univ, Fac Med Nursing & Hlth Sci, Dept Nutr Dietet & Food, Wellington Rd, Clayton, Vic 3800, Australia.
   [Muharram, Farizal Rizky] Airlangga Univ, Med Fac, Jl Mayjen Prof Dr Moestopo 47, Surabaya 60132, Jawa Timur, Indonesia.
   [Taslim, Nurpudji Astuti] Hasanuddin Univ, Fac Med, Clin Nutr, Makassar 90245, Indonesia.
   [Mayulu, Nelly] Sam Ratulangi Univ, Fac Med, Nutr & Food, Manado 95115, Indonesia.
   [Batubara, Siti Chairiyah] Sahid Univ Jakarta, Food Technol Dept, South Jakarta 12870, Indonesia.
   [Samtiya, Mrinal] Cent Univ Haryana, Dept Nutr Biol, Jant 123029, Haryana, India.
   [Hardinsyah, Hardinsyah] IPB Univ, Fac Human Ecol, Appl Nutr, Bogor 16680, West Java, Indonesia.
   [Tsopmo, Apollinaire] Carleton Univ, Dept Chem, 1125 Colonel Dr, Ottawa, ON K1S 5B6, Canada.
C3 Brawijaya University; Diponegoro University; Gadjah Mada University;
   Monash University; Airlangga University; Universitas Hasanuddin;
   Universitas Sam Ratulangi; Central University of Haryana; Bogor
   Agricultural University; Carleton University
RP Permatasari, HK (corresponding author), Brawijaya Univ, Fac Med, Biochem & Biomol, Malang 65145, Indonesia.
EM happykp@ub.ac.id
RI Samtiya, Mrinal/HDO-3545-2022; Tsopmo, Apollinaire/AAA-3306-2019;
   Gunawan, William/GRN-9396-2022; Permatasari, Happy Kurnia/AAY-3402-2021;
   Yusuf, Muhammad/W-4815-2019; sabrina, nindy/ABB-6030-2021; Mayulu,
   Nelly/AAP-3916-2021; Kusuma, Rio/GLV-2439-2022; Nurkolis,
   Fahrul/AAY-1874-2021; Batubara, Siti Chairiyah/GPF-3676-2022; Taslim,
   Nurpduji/AAP-3464-2021
OI permatasari, Happy Kurnia/0000-0002-4777-624X; Yusuf,
   Muhammad/0000-0002-1420-0711; Gunawan, William Ben/0000-0003-0633-4477;
   Muharram, Farizal Rizky/0000-0001-5353-8603; Nurkolis,
   Fahrul/0000-0003-2151-0854; Kusuma, Rio/0000-0003-0762-4361; Astuti,
   Nurpudji/0000-0003-1349-5367
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NR 53
TC 29
Z9 29
U1 1
U2 30
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
EI 2665-9271
J9 CURR RES FOOD SCI
JI Curr. Res. Food Sci.
PY 2022
VL 5
BP 1251
EP 1265
DI 10.1016/j.crfs.2022.08.005
EA AUG 2022
PG 15
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA 4X8TV
UT WOS:000861111200002
PM 36046779
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Nargesi, AA
   Zhu, XY
   Conley, SM
   Woollard, JR
   Saadiq, IM
   Lerman, LO
   Eirin, A
AF Nargesi, Arash Aghajani
   Zhu, Xiang-Yang
   Conley, Sabena M.
   Woollard, John R.
   Saadiq, Ishran M.
   Lerman, Lilach O.
   Eirin, Alfonso
TI Renovascular disease induces mitochondrial damage in swine scattered
   tubular cells
SO AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
LA English
DT Article
DE metabolic syndrome; mitochondria; renal artery stenosis; renovascular
   disease; scattered tubular cells
ID RENAL-ARTERY STENOSIS; PROGENITOR CELLS; GLOMERULAR-FILTRATION;
   STEM-CELLS; KIDNEY; INJURY; REVASCULARIZATION; INHIBITOR; COMPOUND;
   MOLECULE
AB Scattered tubular-like cells (STCs) contribute to repair neighboring injured renal tubular cells. Mitochondria mediate Sit biology and function but might be injured by the ambient milieu. We hypothesized that the microenviroment induced by the ischemic and metabolic components of renovascular disease impairs STC mitochondrial structure and function in swine, which can be attenuated with mitoprotection. CD24(+)/CD133(+) STCs were quantified in pig kidneys after 16 wk of metabolic syndrome (MetS) or lean diet (Lean) with or without concurrent renal artery stenosis (RAS) (n = 6 each). Pig STCs were isolated and characterized, and mitochondrial structure, membrane potential, and oxidative stress were assessed in cells untreated or incubated with the mitoprotective drug elamipretide (1 nM for 6 h). STC-protective effects were assessed in vitro by their capacity to proliferate and improve viability of injured pig tubular epithelial cells. The percentage of STCs was higher in MetS, Lean + RAS, and MetS + RAS kidneys compared with I.ean kidneys. STCs isolated from Lean + RAS and MetS + RAS pigs showed mitochondrial swelling and decreased matrix density, which were both restored by mitoprotection. In addition. mitochondrial membrane potential and ATP production were reduced and production of reactive oxygen species elevated in MetS, Lean + RAS, and MetS + RAS STCs. Importantly. mitoprotection improved mitochondrial structure and function as well as the capacity of MetS + RAS STCs to repair injured tubular cells in vitro. Renovascular disease in swine is associated with a higher prevalence of STCs but induces structural and functional alterations in STC mitochondria, which impair their reparative potency. These observations suggest a key role for mitochondria in the renal reparative capacity of STCs.
C1 [Nargesi, Arash Aghajani; Zhu, Xiang-Yang; Conley, Sabena M.; Woollard, John R.; Saadiq, Ishran M.; Lerman, Lilach O.; Eirin, Alfonso] Mayo Clin, Div Nephrol & Hypertens, Dept Internal Med, Rochester, MN 55905 USA.
C3 Mayo Clinic
RP Eirin, A (corresponding author), Mayo Clin, Div Nephrol & Hypertens, 200 First St SW, Rochester, MN 55905 USA.
EM eirinmassat.alfonso@mayo.edu
RI Lerman, Lilach/M-4962-2017; Eirin, Alfonso/N-9873-2013; Nargesi,
   Arash/AAM-5298-2020
OI Eirin, Alfonso/0000-0002-3864-9644
FU National Institutes of Health [DK106427, DK-122137, DK-104273,
   DK-120292, DK-102325, HL-123160]
FX This work was supported by National Institutes of Health Grants
   DK106427, DK-122137, DK-104273, DK-120292, DK-102325, and HL-123160.
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NR 53
TC 22
Z9 23
U1 0
U2 5
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 1931-857X
EI 1522-1466
J9 AM J PHYSIOL-RENAL
JI Am. J. Physiol.-Renal Physiol.
PD NOV
PY 2019
VL 317
IS 5
BP F1142
EP F1153
DI 10.1152/ajprenal.00276.2019
PG 12
WC Physiology; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology; Urology & Nephrology
GA JP6SN
UT WOS:000498393200007
PM 31461348
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Scrimgeour, LA
   Potz, BA
   Gheit, AA
   Shi, GB
   Stanley, M
   Zhang, Z
   Sodha, NR
   Ahsan, N
   Abid, MR
   Sellke, FW
AF Scrimgeour, Laura A.
   Potz, Brittany A.
   Gheit, Ahmad Aboul
   Shi, Guangbin
   Stanley, Melissa
   Zhang, Zhiqi
   Sodha, Neel R.
   Ahsan, Nagib
   Abid, M. Ruhul
   Sellke, Frank W.
TI Extracellular Vesicles Promote Arteriogenesis in Chronically Ischemic
   Myocardium in the Setting of Metabolic Syndrome
SO JOURNAL OF THE AMERICAN HEART ASSOCIATION
LA English
DT Article
DE angiogenesis; cardiovascular disease; coronary vessels; extracellular
   vesicles
ID COLLATERAL-DEPENDENT PERFUSION; CARDIOMYOCYTE APOPTOSIS; OXIDATIVE
   STRESS; CELLS; MODEL; ANGIOGENESIS; INFARCTION; MORTALITY; SWINE
AB Background-Ischemic heart disease continues to be a leading cause of mortality in patients. Extracellular vesicles (EVs) provide a potential for treatment that may induce collateral vessel growth to increase myocardial perfusion.
   Methods and Results-Nineteen male Yorkshire pigs were given a high-fat diet for 4 weeks, then underwent placement of an ameroid constrictor on the left circumflex artery to induce chronic myocardial ischemia. Two weeks later, the pigs received either intramyocardial vehicle (n=6), EVs (high-fat diet with myocardial EV injection [HVM]; n=8), or HVM and calpain inhibition (n=5). Five weeks later, myocardial function, perfusion, coronary vascular density, and cell signaling were examined. Perfusion in the collateral dependent myocardium was increased during rapid ventricular pacing in the HVM group in both nonischemic (P=0.04) and ischemic areas of the ventricle (P=0.05). Cardiac output and stroke volume were significantly improved in the HVM group compared with the control group during ventricular pacing (P=0.006). Increased arteriolar density was seen in the HVM group in both nonischemic and ischemic myocardium (P=0.003 for both). However, no significant changes in the capillary density were observed between the control, HVM, and HVM and calpain inhibition groups (P=0.07). The group that received EVs with oral calpain inhibition had neither increased vessel density (P>0.99) nor improvement in blood flow or cardiac function (P=0.48) when compared with the control group.
   Conclusions-These findings suggest that EVs promote angiogenesis in areas of chronic myocardial ischemia and improve cardiac function under conditions of diet-induced metabolic syndrome.
C1 [Scrimgeour, Laura A.; Potz, Brittany A.; Gheit, Ahmad Aboul; Shi, Guangbin; Stanley, Melissa; Zhang, Zhiqi; Sodha, Neel R.; Abid, M. Ruhul; Sellke, Frank W.] Brown Univ, Rhode Isl Hosp, Dept Surg, Warren Alpert Med Sch,Div Cardiothorac Surg,Cardi, Providence, RI 02905 USA.
   [Ahsan, Nagib] Rhode Isl Hosp, Ctr Biomed Res Excellence, Ctr Canc Res Dev, Prote Core Facil, Providence, RI USA.
   [Ahsan, Nagib] Brown Univ, Div Biol & Med, Providence, RI 02905 USA.
C3 Lifespan Health Rhode Island; Rhode Island Hospital; Brown University;
   Lifespan Health Rhode Island; Rhode Island Hospital; National Institutes
   of Health (NIH) - USA; NIH National Institute of General Medical
   Sciences (NIGMS); Brown University
RP Sellke, FW (corresponding author), Brown Univ, Div Cardiothorac Surg, Warren Alpert Med Sch, 2 Dudley St,MOC 360, Providence, RI 02905 USA.
EM fsellke@lifespan.org
RI Zhang, Zhiqi/AAL-9346-2020
OI Zhang, Zhiqi/0000-0001-7565-5456
FU National Heart, Lung, and Blood Institute (NHLBI) [R01HL46716,
   R01HL128831-01A1]; American Heart Association [14GRNT 20460291];
   National Institutes of Health/National Institute of General Medical
   Sciences Training Grant [2T32 GM065085-12, 2T32 GM065085-13]; NHLBI
   [1R01HL133624]
FX Funding for this research was provided by the National Heart, Lung, and
   Blood Institute (NHLBI) (R01HL46716 and R01HL128831-01A1 [Dr Sellke]);
   NHLBI 1R01HL133624 and American Heart Association Grant-in-Aid 14GRNT
   20460291 (Dr Abid); and National Institutes of Health/National Institute
   of General Medical Sciences Training Grant 2T32 GM065085-12 (Dr Potz)
   and 2T32 GM065085-13 (Dr Scrimgeour).
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NR 42
TC 33
Z9 34
U1 0
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
EI 2047-9980
J9 J AM HEART ASSOC
JI J. Am. Heart Assoc.
PD AUG 6
PY 2019
VL 8
IS 15
AR e012617
DI 10.1161/JAHA.119.012617
PG 14
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA IV9KT
UT WOS:000484583500034
PM 31354010
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Nevelsteen, I
   Van den Bergh, A
   Van der Mieren, G
   Vanderper, A
   Mubagwa, K
   Bult, H
   Herijgers, P
AF Nevelsteen, Ines
   Van den Bergh, An
   Van der Mieren, Gerry
   Vanderper, Annelies
   Mubagwa, Kanigula
   Bult, Hidde
   Herijgers, Paul
TI NO-Dependent Endothelial Dysfunction in Type II Diabetes Is Aggravated
   by Dyslipidemia and Hypertension, but Can Be Restored by
   Angiotensin-Converting Enzyme Inhibition and Weight Loss
SO JOURNAL OF VASCULAR RESEARCH
LA English
DT Article
DE Angiotensin-converting enzyme inhibition; Diabetes mellitus type II;
   Endothelial dysfunction; Metabolic syndrome; Weight loss
ID LOW-DENSITY-LIPOPROTEIN; VASCULAR SMOOTH-MUSCLE;
   AMERICAN-HEART-ASSOCIATION; E-DEFICIENT MICE; OXIDATIVE STRESS;
   CARDIOVASCULAR-DISEASES; CORONARY-CIRCULATION; ACE-INHIBITORS; OBESE
   WOMEN; RECEPTOR
AB Aims: Insulin resistance, dyslipidemia and hypertension are independent mediators of endothelial dysfunction. It is incompletely defined whether dyslipidemia and hypertension in addition to diabetes mellitus type II (DMII), as seen in the metabolic syndrome (MS), worsen diabetes-induced endothelial dysfunction. Furthermore, it is unclear whether treatment influences endothelial dysfunction similarly in MS and DMII. Therefore, we studied vascular reactivity and the effect of in vivo treatment with angiotensin-converting enzyme inhibition (ACE-I) or hypocaloric diet in LDL receptor-and leptin-deficient (ob/ob), double knockout mice (DKO), featuring MS and in ob/ob mice with DMII. Methods and Results: Vascular reactivity was studied in isolated aortic ring segments. Maximum vasorelaxant response to acetylcholine (Ach) was more depressed in DKO than in ob/ob mice, whereas response to bradykinin (BK) was equally attenuated in both genotypes (52 +/- 3 and 23 +/- 9% reversal of preconstriction induced by 10(-7) M phenylephrine in DKO vs. 76 +/- 3 and 23 +/- 8% reversal of preconstriction in ob/ob mice, respectively). ACE-I and hypocaloric diet improved ACh-induced vasorelaxation significantly (89 +/- 2 and 59 +/- 2% reversal of preconstriction in DKO vs. 80 +/- 3 and 84 +/- 4% in ob/ob mice, respectively), but not the response to BK. Conclusion: These results indicate a differential impact of DMII and MS on endothelial function. ACE-I and hypocaloric diet improved ACh-, but not BK-induced vasorelaxation in these mouse models of DMII and MS. (C) 2013 S. Karger AG, Basel
C1 [Nevelsteen, Ines; Van den Bergh, An; Van der Mieren, Gerry; Vanderper, Annelies; Mubagwa, Kanigula; Herijgers, Paul] Katholieke Univ Leuven, Dept Cardiovasc Sci, Res Unit Expt Cardiac Surg, BE-3000 Louvain, Belgium.
   [Bult, Hidde] Univ Antwerp, Dept Pharmacol, B-2020 Antwerp, Belgium.
C3 KU Leuven; University of Antwerp
RP Herijgers, P (corresponding author), Katholieke Univ Leuven, Herestr 49, BE-3000 Louvain, Belgium.
EM paul.herijgers@med.kuleuven.be
RI Herijgers, Paul/B-8064-2013; Bult, Hidde/J-5342-2013
OI Herijgers, Paul/0000-0003-0951-8132
FU Research Foundation-Flanders (FWO); Research Fund KU Leuven-Bijzonder
   Onderzoeksfonds [OT 04/39, OT 05/55, PF/10/014]
FX This study was supported by a PhD fellowship of the Research
   Foundation-Flanders (FWO) to Ines Nevelsteen and by a grant of the
   Research Fund KU Leuven-Bijzonder Onderzoeksfonds (OT 04/39, OT 05/55
   and PF/10/014).
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NR 63
TC 16
Z9 17
U1 0
U2 5
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1018-1172
EI 1423-0135
J9 J VASC RES
JI J. Vasc. Res.
PY 2013
VL 50
IS 6
BP 486
EP 497
DI 10.1159/000355221
PG 12
WC Physiology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology; Cardiovascular System & Cardiology
GA 262XQ
UT WOS:000327771600005
PM 24192582
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Hayden, MR
   Sowers, JR
AF Hayden, Melvin R.
   Sowers, James R.
TI Childhood-Adolescent Obesity in the Cardiorenal Syndrome: Lessons from
   Animal Models
SO CARDIORENAL MEDICINE
LA English
DT Article
DE Adolescence; Childhood; Diabetes; Obesity; Rodent models;
   Ultrastructural remodeling
ID BODY-MASS INDEX; METABOLIC SYNDROME; INSULIN-RESISTANCE; PEDIATRIC
   OBESITY; OXIDATIVE STRESS; GLUCOSE-LEVELS; UNITED-STATES; RISK-FACTORS;
   CHILDREN; DISEASE
AB Background/Aims: Childhood-adolescent overweight and obesity have grown to pandemic proportions during the past decade. The onset of obesity in younger adults will likely be manifested as earlier onset of myocardial and renal end-organ disease in younger adults. For the first time, it is estimated that the current generation may not live to be as old as their parents. Thus, it is important to develop animal models of childhood obesity to understand fundamental pathological organ changes. Methods: In this regard, we utilize transmission electron microscopy evaluation to evaluate early remodeling changes of two adolescent rodent obesity models: the Zucker obese (fa/fa) rat and the db/db mouse models of obesity. We have concentrated on the initial ultrastructural remodeling (obese adipose tissue, skeletal muscle, and islet remodeling) and the associated changes in target end organs (including the myocardium and kidney) in young rodent models of obesity and insulin resistance, collectively manifesting as the cardiorenal metabolic syndrome (CRS). Results: Briefly, tissues revealed the following ultrastructural remodeling abnormalities: inflammation, hypertrophy, and early fibrosis in adipose tissue; loss of mitochondria in skeletal muscles, hyperplasia, fibrosis, and depletion of insulin-secretory granules in pancreatic islets; increased intramyocardial lipid accumulation, fibrosis, and mitochondrial deposition in the myocardium, and obesity-related glomerulopathy and tubulopathy in the kidney. Conclusion: Based on the current knowledge and ultrastructural observations of organ pathology, we propose mechanisms whereby obesity appears to be the driving force behind the development of the CRS. Copyright (C) 2011 S. Karger AG, Basel
C1 [Sowers, James R.] Univ Missouri, Dept Med Pharmacol & Physiol, Sch Med, Columbia, MO 65212 USA.
   [Hayden, Melvin R.; Sowers, James R.] Diabet & Cardiovasc Ctr, Columbia, MO USA.
   [Sowers, James R.] Harry S Truman VA Med Ctr, Columbia, MO USA.
   [Hayden, Melvin R.; Sowers, James R.] Univ Missouri, Sch Med, Dept Internal Med, Div Endocrinol, Columbia, MO 65212 USA.
C3 University of Missouri System; University of Missouri Columbia;
   University of Missouri System; University of Missouri Columbia; US
   Department of Veterans Affairs; Veterans Health Administration (VHA);
   Harry S. Truman Memorial Veterans' Hospital; University of Missouri
   System; University of Missouri Columbia
RP Hayden, MR (corresponding author), D109 HSC Diabet Ctr, 1 Hosp Dr, Columbia, MO 65212 USA.
EM mrh29@usmo.com
FU National Institutes of Health [R01 HL73101-01A1]; Veterans Affairs Merit
   System [0018]
FX This research was supported by the National Institutes of Health (R01
   HL73101-01A1), Veterans Affairs Merit System 0018 (J.R.S.).
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NR 35
TC 7
Z9 9
U1 0
U2 2
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1664-3828
J9 CARDIORENAL MED
JI CardioRenal Med.
PY 2011
VL 1
IS 2
BP 75
EP 86
DI 10.1159/000327022
PG 12
WC Cardiac & Cardiovascular Systems; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Urology & Nephrology
GA 051ZL
UT WOS:000312167400001
PM 22294984
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Reiterer, M
   Gilani, A
   Lo, JC
AF Reiterer, Moritz
   Gilani, Ankit
   Lo, James C.
TI Pancreatic Islets as a Target of Adipokines
SO COMPREHENSIVE PHYSIOLOGY
LA English
DT Article
ID BETA-CELL FUNCTION; RETINOL-BINDING-PROTEIN; BROWN ADIPOSE-TISSUE;
   REGULATES INSULIN-SECRETION; FATTY-ACID-COMPOSITION; FUNCTIONAL LEPTIN
   RECEPTOR; TYPE-2 DIABETES-MELLITUS; ATP CHANNEL TRAFFICKING; SERUM
   RESISTIN LEVELS; METABOLIC SYNDROME
AB Rising rates of obesity are intricately tied to the type 2 diabetes epidemic. The adipose tissues can play a central role in protection against or triggering metabolic diseases through the secretion of adipokines. Many adipokines may improve peripheral insulin sensitivity through a variety of mechanisms, thereby indirectly reducing the strain on beta cells and thus improving their viability and functionality. Such effects will not be the focus of this article. Rather, we will focus on adipocyte-secreted molecules that have a direct effect on pancreatic islets. By their nature, adipokines represent potential druggable targets that can reach the islets and improve beta-cell function or preserve beta cells in the face of metabolic stress. (c) 2022 American Physiological Society. Compr Physiol 12:4039-4065, 2022.
C1 [Reiterer, Moritz; Gilani, Ankit; Lo, James C.] Weill Cornell Med, Cardiovasc Res Inst, Weill Ctr Metab Hlth, Div Cardiol,Dept Med, New York, NY 10065 USA.
C3 Cornell University; Weill Cornell Medicine
RP Lo, JC (corresponding author), Weill Cornell Med, Cardiovasc Res Inst, Weill Ctr Metab Hlth, Div Cardiol,Dept Med, New York, NY 10065 USA.
EM jlo@med.cornell.edu
FU NIH [R01 DK121140, R01 DK121844]; Chan Zuckerberg Initiative; Irma T.
   Hirschl Trust; Feldstein Medical Foundation
FX Research in the Lo Lab is supported by NIH R01 DK121140, R01 DK121844;
   funding from the Chan Zuckerberg Initiative, Irma T. Hirschl Trust, and
   the Feldstein Medical Foundation. The views expressed in thismanuscript
   are those of the authors and do not necessarily represent the official
   views of the National Institute of Diabetes and Digestive and Kidney
   Diseases or the National Institutes of Health. Figures were created with
   BioRender.com.
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NR 368
TC 2
Z9 2
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 2040-4603
J9 COMPR PHYSIOL
JI Compr. Physiol.
PD OCT
PY 2022
VL 12
IS 4
BP 4039
EP 4065
DI 10.1002/cphy.c210044
PG 27
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA D0DF5
UT WOS:000965512300010
PM 35950650
DA 2025-06-11
ER

PT J
AU Kimura, Y
   Tsukui, D
   Kono, H
AF Kimura, Yoshitaka
   Tsukui, Daisuke
   Kono, Hajime
TI Uric Acid in Inflammation and the Pathogenesis of Atherosclerosis
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE hyperuricemia; atherosclerosis; inflammation; reactive oxygen species
ID ACTIVATED PROTEIN-KINASE; XANTHINE-OXIDASE INHIBITION;
   SMOOTH-MUSCLE-CELLS; OXIDATIVE STRESS; ENDOTHELIAL DYSFUNCTION;
   CARDIOVASCULAR-DISEASE; ASYMPTOMATIC HYPERURICEMIA; INSULIN-RESISTANCE;
   NADPH OXIDASE; ALLOPURINOL
AB Hyperuricemia is a common metabolic syndrome. Elevated uric acid levels are risk factors for gout, hypertension, and chronic kidney diseases. Furthermore, various epidemiological studies have also demonstrated an association between cardiovascular risks and hyperuricemia. In hyperuricemia, reactive oxygen species (ROS) are produced simultaneously with the formation of uric acid by xanthine oxidases. Intracellular uric acid has also been reported to promote the production of ROS. The ROS and the intracellular uric acid itself regulate several intracellular signaling pathways, and alterations in these pathways may result in the development of atherosclerotic lesions. In this review, we describe the effect of uric acid on various molecular signals and the potential mechanisms of atherosclerosis development in hyperuricemia. Furthermore, we discuss the efficacy of treatments for hyperuricemia to protect against the development of atherosclerosis.
C1 [Kimura, Yoshitaka; Tsukui, Daisuke; Kono, Hajime] Teikyo Univ Med, Dept Internal Med, Fac Med, Tokyo 1738605, Japan.
   [Kimura, Yoshitaka] Teikyo Univ Med, Dept Microbiol & Immunol, Fac Med, Tokyo 1738605, Japan.
C3 Teikyo University; Teikyo University
RP Kono, H (corresponding author), Teikyo Univ Med, Dept Internal Med, Fac Med, Tokyo 1738605, Japan.
EM yo.kimura.july@med.teikyo-u.ac.jp; tsukui@med.teikyo-u.ac.jp;
   kono@med.teikyo-u.ac.jp
RI Kimura, Yoshitaka/AFD-1959-2022
OI Kono, Hajime/0000-0002-4578-8677; Kimura, Yoshitaka/0000-0001-5430-9909
FU JSPS KAKENHI [JP21K16217, JP21K08480]
FX This research was funded by JSPS KAKENHI Grant Numbers JP21K16217,
   JP21K08480.
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NR 123
TC 174
Z9 179
U1 12
U2 105
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD NOV
PY 2021
VL 22
IS 22
AR 12394
DI 10.3390/ijms222212394
PG 19
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA XG8RT
UT WOS:000725015600001
PM 34830282
OA gold, Green Published
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Liu, XY
   Zhou, LP
   Huang, WJ
   Yang, YY
   Yang, YJ
   Liu, TW
   Guo, MJ
   Yu, T
   Li, YX
AF Liu, Xiangyu
   Zhou, Liping
   Huang, Wenjing
   Yang, Yanyan
   Yang, Yijun
   Liu, Tianwei
   Guo, Mingjin
   Yu, Tao
   Li, Yongxin
TI Proteomic Analysis and 2-Hydroxyisobutyrylation Profiling in Metabolic
   Syndrome Induced Restenosis
SO MOLECULAR & CELLULAR PROTEOMICS
LA English
DT Article
ID IN-STENT RESTENOSIS; LYSINE 2-HYDROXYISOBUTYRYLATION; REVASCULARIZATION;
   DISEASE; MICE
AB Restenosis is the primary complication following stenting for coronary and peripheral arterial disease, posing an ongoing clinical challenge. Metabolic syndrome (MetS), characterized by metabolic disturbances, has been identified as an independent predictor for postoperative restenosis in coronary and carotid arteries, potentially due to endothelial dysfunction and augmented oxidative stress in cells, while its specific regulatory mechanism is still largely unknown. Lysine 2-hydroxyisobutyrylation (Khib), a recently identified posttranslational modification, plays a crucial role in transcriptional regulation and cellular metabolism. However, there is a lack of comprehensive analysis of the proteome and Khib modifications within restenotic vessels in the context of MetS, as well as in the understanding of the associated pathophysiology. In this study, we observed a significant upregulation of Khib in restenotic arteries induced by MetS, confirmed by animal and cellular experiments. Further, using high-throughput liquid chromatography-mass spectrometry, we catalogued 15,558 Khib sites across 2568 proteins, implicating a multitude of biological functions. Analysis revealed 2007 Khib sites on 1002 proteins with considerable differential modifications which are present within the cytoplasm and nucleus. Interestingly, proteins located in the mitochondria, endoplasmic reticulum, and cell membrane also exhibit distinct expression and modification profiles to varying extents that related to vascular smooth muscle contraction, platelet activation, and the PI3K-Akt signaling pathway. Notably, the level of COL1A1 protein detected in the protein-protein interaction pathway network and the level of Khib modification are diametrically opposed, suggesting a significant role in the disease's pathogenesis. This study provides the first comprehensive proteomic and Khib modification overview of MetS-related instent restenosis vasculature, offering key insights to inform novel therapeutic approaches for restenosis mitigation.
C1 [Liu, Xiangyu; Huang, Wenjing; Guo, Mingjin; Li, Yongxin] Qingdao Univ, Dept Vasc Surg, Affiliated Hosp, Qingdao, Shandong, Peoples R China.
   [Zhou, Liping] Hong Kong Polytech Univ, Sch Optometry, Kowloon, Hong Kong, Peoples R China.
   [Zhou, Liping] Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Kowloon, Hong Kong, Peoples R China.
   [Yang, Yanyan] Qingdao Univ, Sch Basic Med, Dept Immunol, Qingdao, Shandong, Peoples R China.
   [Yang, Yijun] Qingdao Univ, Arch Dept, Affiliated Hosp, Qingdao, Shandong, Peoples R China.
   [Liu, Tianwei] Qingdao Univ, Med Res Ctr, Affiliated Hosp, Qingdao, Shandong, Peoples R China.
   [Yu, Tao] Qingdao Univ, Affiliated Hosp, Inst Translat Med, Qingdao, Shandong, Peoples R China.
C3 Qingdao University; Hong Kong Polytechnic University; Hong Kong
   Polytechnic University; Qingdao University; Qingdao University; Qingdao
   University; Qingdao University
RP Guo, MJ; Li, YX (corresponding author), Qingdao Univ, Dept Vasc Surg, Affiliated Hosp, Qingdao, Shandong, Peoples R China.; Yu, T (corresponding author), Qingdao Univ, Affiliated Hosp, Inst Translat Med, Qingdao, Shandong, Peoples R China.
EM qduahvasc@163.com; yutao0112@qdu.edu.cn; alexander1985827@163.com
FU National Natural Science Foundation of China [82270518, 82270442];
   Taishan Scholar Program of Shandong Province [tsqn202408156]; Qingdao
   West Coast New Area Science and Technology Project [2022-57]; Natural
   Science Foundation of Shandong Province [ZR2022MH031]
FX This work was supported by the National Natural Science Foundation of
   China (No. 82270518, 82270442) , Taishan Scholar Program of Shandong
   Province (No. tsqn202408156) , Qingdao West Coast New Area Science and
   Technology Project (No. 2022-57) , and the Natural Science Foundation of
   Shandong Province (No. ZR2022MH031) .
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NR 58
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
EI 1535-9484
J9 MOL CELL PROTEOMICS
JI Mol. Cell. Proteomics
PD JUN
PY 2025
VL 24
IS 6
AR 100978
DI 10.1016/j.mcpro.2025.100978
PG 19
WC Biochemical Research Methods
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 3KO5O
UT WOS:001502567500001
PM 40287094
DA 2025-06-11
ER

PT J
AU Lockwood, F
   Lachaux, M
   Harouki, N
   Soulié, M
   Nicol, L
   Renet, S
   Dumesnil, A
   Vercauteren, M
   Bellien, J
   Iglarz, M
   Richard, V
   Mulder, P
AF Lockwood, Francesca
   Lachaux, Marianne
   Harouki, Najah
   Soulie, Matthieu
   Nicol, Lionel
   Renet, Sylvanie
   Dumesnil, Anais
   Vercauteren, Magali
   Bellien, Jeremy
   Iglarz, Marc
   Richard, Vincent
   Mulder, Paul
TI Dual ETA-ETB receptor antagonism improves
   metabolic syndrome-induced heart failure with preserved ejection
   fraction
SO FUNDAMENTAL & CLINICAL PHARMACOLOGY
LA English
DT Article
DE cardiac remodelling; endothelin; heart failure; metabolic syndrome
ID ENDOTHELIAL DYSFUNCTION; VENTRICULAR HYPERTROPHY; COLLAGEN TURNOVER;
   ZUCKER OBESE; RAT MODELS; MACITENTAN; BOSENTAN; HYPERTENSION; REDUCTION;
   PROGRESSION
AB BackgroundMetabolic syndrome (MetS) is a multifaceted disease associated with heart failure (HF), which affects the vascular system. The endothelin (ET) system is a key player in MetS and HF; therefore, targets for ET receptors are of therapeutic interest.ObjectivesThis study sought to evaluate the effects of macitentan, a dual endothelin receptor antagonist (ERA), in a rat model of MetS-induced heart failure with preserved ejection fraction (HFpEF).MethodsWe assessed in 12-week-old Zucker fa/fa rats the effects of macitentan (10 mg/kg/day as a food additive for short-term/7- or long-term/90-day treatment) on right ventricular (RV) and left ventricular (LV) function/remodelling (MRI), RV and LV haemodynamics (catheterization) and RV and LV coronary function (myograph).ResultsAfter 7- and 90-days, untreated Zucker fa/fa rats presented isolated LV diastolic dysfunction (illustrated by elevated LV end-diastolic pressure [EDP] and LV end-diastolic pressure-volume relationship [EDPVR] without changes in LV EDPVR). This was associated with increased collagen deposition and impaired endothelium-dependent coronary artery relaxation. Macitentan 7- and 90-day treatment significantly decreased blood pressure and prevented LV, RV and coronary dysfunctions and long-term treatment reduced LV collagen density. Moreover, 7- and 90-day macitentan treatment significantly reduced cardiac inflammation and reactive oxygen species (ROS) production.ConclusionsDual ERA macitentan improved both LV and RV diastolic dysfunction. This was associated with improved coronary vasodilation, diminished cardiac oxidative stress and improved blood composition. These results suggest that antagonizing the ET system with macitentan is a promising approach to treat HFpEF and its complications.
C1 [Lockwood, Francesca; Lachaux, Marianne; Harouki, Najah; Soulie, Matthieu; Nicol, Lionel; Renet, Sylvanie; Dumesnil, Anais; Bellien, Jeremy; Richard, Vincent; Mulder, Paul] Univ Rouen Normandie, INSERM, U1096, EnVI, 22 Bd Gambetta, F-76000 Rouen, France.
   [Lockwood, Francesca] Univ Oslo, Inst Clin Med, Med Fac, Oslo, Norway.
   [Vercauteren, Magali; Iglarz, Marc] Idorsia Pharmaceut Ltd, Allschwil, Switzerland.
C3 Institut National de la Sante et de la Recherche Medicale (Inserm);
   Universite de Rouen Normandie; University of Oslo; Idorsia
   Pharmaceuticals Ltd
RP Mulder, P (corresponding author), Univ Rouen Normandie, INSERM, U1096, EnVI, 22 Bd Gambetta, F-76000 Rouen, France.
EM paul.mulder@univ-rouen.fr
FU Actelion Pharmaceuticals
FX The authors thank Daniel Strasser and Herve Farine for their excellent
   technical assistance.
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NR 77
TC 0
Z9 0
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0767-3981
EI 1472-8206
J9 FUND CLIN PHARMACOL
JI Fundam. Clin. Pharmacol.
PD JUN
PY 2025
VL 39
IS 3
AR e70006
DI 10.1111/fcp.70006
PG 18
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 2ZN2C
UT WOS:001495035700002
PM 40203840
OA hybrid
DA 2025-06-11
ER

PT J
AU Adeyanju, OA
   Badejogbin, OC
   Areola, DE
   Olaniyi, KS
   Dibia, C
   Soetan, OA
   Oniyide, AA
   Michael, OS
   Olatunji, LA
   Soladoye, AO
AF Adeyanju, Oluwaseun A.
   Badejogbin, Olabimpe C.
   Areola, Damilare E.
   Olaniyi, Kehinde S.
   Dibia, Chinaza
   Soetan, Olaniyi A.
   Oniyide, Adesola A.
   Michael, Olugbenga S.
   Olatunji, Lawrence A.
   Soladoye, Ayodele O.
TI Sodium butyrate arrests pancreato-hepatic synchronous uric acid and
   lipid dysmetabolism in high fat diet fed Wistar
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Article
DE Pancreas; Short chain fatty acids; NAFLD; Uric acid; High fat diet
ID INSULIN-RESISTANCE; METABOLIC SYNDROME; OXIDATIVE STRESS; LIVER;
   DYSFUNCTION; LIPOTOXICITY; DISEASE; INFLAMMASOME; ADIPOCYTES; CELLS
AB High fat diet (HFD) is a risk factor for metabolic syndrome which is characterized by overt glucose dysmetabolism and tissue derangement. The liver and pancreas are important metabolic tissues with anatomical proximity sharing splanchnic and mesenteric circulation but it is unclear whether, there is an associated metabolic status between the two organs in health and disease. Uric acid (UA) hypersecretion and ectopic lipid accumulation are characteristic pathophysiology of an array of non-communicable diseases. Sodium butyrate (BUT) is reputed for therapeutic roles in metabolic derangement. Therefore, the present study investigated synchrony in hepatic and pancreatic UA and lipid metabolic status in HFD-induced glucose dysregulation and probed the beneficial effects of BUT. Twenty-four female Wistar rats were treated with normal rat chow and distilled water (po) or sodium butyrate (200 mg/kg; po) or high fat diet and distilled water (po) or high fat diet and sodium butyrate. Results showed that HFD increased plasma, pancreatic and hepatic triglyceride, triglyceride-glucose index, malondialdehyde, uric acid (UA), lactate dehydrogenase but reduced glucose-6-phosphate dehydrogenase. Histological analysis revealed hepatic and pancreatic architectural derangement and cellular degeneration in HFD-fed animals. However, BUT reversed the HFD-induced systemic, pancreatic and hepatic synchronous dysmetabolism with evidence of improved histology. HFD-induced lipid and UA alterations were synchronous in the pancreas and liver. BUT elicits beneficial effects on systemic and tissue HFD-induced deleterious metabolic changes which were synchronized in pancreas and liver of rats.
C1 [Adeyanju, Oluwaseun A.; Badejogbin, Olabimpe C.; Olaniyi, Kehinde S.; Oniyide, Adesola A.] Afe Babalola Univ, Dept Physiol, Coll Med & Hlth Sci, Cardiometab Res Unit, Ado Ekiti, Nigeria.
   [Adeyanju, Oluwaseun A.; Areola, Damilare E.; Olaniyi, Kehinde S.; Dibia, Chinaza; Soetan, Olaniyi A.; Michael, Olugbenga S.; Olatunji, Lawrence A.] Univ Ilorin, HOPE Cardiometab Res Team, Ilorin, Nigeria.
   [Adeyanju, Oluwaseun A.; Areola, Damilare E.; Olaniyi, Kehinde S.; Dibia, Chinaza; Soetan, Olaniyi A.; Michael, Olugbenga S.; Olatunji, Lawrence A.] Univ Ilorin, Dept Physiol, Ilorin, Nigeria.
   [Areola, Damilare E.; Olatunji, Lawrence A.] Univ Ilorin, Dept Physiol, Coll Hlth Sci, Ilorin, Nigeria.
   [Dibia, Chinaza] Nnamdi Azikiwe Univ, Dept Physiol, Awka, Anambra State, Nigeria.
   [Michael, Olugbenga S.; Soladoye, Ayodele O.] Bowen Univ, Dept Physiol, Coll Hlth Sci, Cardiometab Res Unit, Iwo, Nigeria.
C3 University of Ilorin; University of Ilorin; University of Ilorin
RP Adeyanju, OA (corresponding author), Afe Babalola Univ, Dept Physiol, PMB 5454, Ado Ekiti 360101, Nigeria.
EM adeyanjuoa@abuad.edu.ng
RI Michael, Olugbenga/GWN-0706-2022; Olaniyi, Kehinde/GPK-5850-2022;
   Adeyanju, Oluwaseun/HJP-1273-2023
OI Olaniyi, Kehinde/0000-0002-8229-9688; Adeyanju,
   Oluwaseun/0000-0003-4824-6766; Soetan, Olaniyi/0000-0002-1670-9263;
   Olatunji, Lawrence Aderemi/0000-0002-1036-0662
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NR 48
TC 33
Z9 36
U1 2
U2 23
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD JAN
PY 2021
VL 133
AR 110994
DI 10.1016/j.biopha.2020.110994
PG 9
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA PN6QU
UT WOS:000604602300004
PM 33197764
OA gold
DA 2025-06-11
ER

PT J
AU de Oliveira, PGFP
   Bonfante, EA
   Bergamo, ETP
   de Souza, SLS
   Riella, L
   Torroni, A
   Jalkh, EBB
   Witek, L
   Lopez, CD
   Zambuzzi, WF
   Coelho, PG
AF de Oliveira, Paula Gabriela Faciola Pessoa
   Bonfante, Estevam A.
   Bergamo, Edmara T. P.
   de Souza, Sergio Luis Scombatti
   Riella, Leonardo
   Torroni, Andrea
   Jalkh, Ernesto B. Benalcazar
   Witek, Lukasz
   Lopez, Christopher D.
   Zambuzzi, Willian Fernando
   Coelho, Paulo G.
TI Obesity/Metabolic Syndrome and Diabetes Mellitus on Peri-implantitis
SO TRENDS IN ENDOCRINOLOGY AND METABOLISM
LA English
DT Review
ID NITRIC-OXIDE SYNTHASE; OSTEOBLAST ADHESION; IN-VIVO; MICROVASCULAR
   COMPLICATIONS; PERIODONTAL-DISEASE; CELL PROLIFERATION;
   GLUCOSE-METABOLISM; INSULIN-RESISTANCE; ENDOTHELIAL-CELLS;
   GENE-EXPRESSION
AB Literature has reported that up to 50% of dental implants may be affected by peri-implantitis, a bacteria-induced chronic inflammatory process, which promotes osteoclast-mediated bone resorption and inhibits bone formation, leading to progressive bone loss around implants. Current evidence points toward an increased risk for the development of peri-implantitis in both obesity/metabolic syndrome (MetS) and diabetes mellitus (DM) conditions relative to the healthy population. Currently, there is no effective treatment for peri-implantitis and the 50% prevalence in MetS and DM, along with its predicted increase in the worldwide population, presents a major concern in implant dentistry as hyperglycemic conditions are associated with bone-healing impairment; this may be through dysfunction of osteocalcin-induced glucose metabolism. The MetS/DM proinflammatory systemic condition and altered immune/microbiome response affect both catabolic and anabolic events of bone-healing that include increased osteoclastogenesis and compromised osteoblast activity, which could be explained by the dysfunction of insulin receptor that led to activation of signals related with osteoblast differentiation. Furthermore, chronic hyperglycemia along with associated micro- and macro-vascular ailments leads to delayed/impaired wound healing due to activation of pathways that are particularly important in initiating events linked to inflammation, oxidative stress, and cell apoptosis; this may be through deactivation of AKT/PKB protein, which possesses a pivotal role in drive survival and eNOS signaling. This review presents an overview of the local and systemic mechanisms synergistically affecting bone-healing impairment in MetS/DM individuals, as well as a rationale for hierarchical animal model selection, in an effort to characterize peri-implantitis disease and treatment.
C1 [de Oliveira, Paula Gabriela Faciola Pessoa; Jalkh, Ernesto B. Benalcazar; Witek, Lukasz; Coelho, Paulo G.] NYU, Coll Dent, Dept Biomat & Biomimet, New York, NY 10010 USA.
   [de Oliveira, Paula Gabriela Faciola Pessoa; de Souza, Sergio Luis Scombatti] Univ Sao Paulo, Dept Oral & Maxillofacial Surg & Periodont, Sch Dent Ribeirao Preto, Ribeirao Preto, SP, Brazil.
   [de Oliveira, Paula Gabriela Faciola Pessoa] Univ Ctr State Para, Sch Dent, Dept Periodontol, Belem, PA, Brazil.
   [Bonfante, Estevam A.; Bergamo, Edmara T. P.; Jalkh, Ernesto B. Benalcazar] Univ Sao Paulo, Bauru Sch Dent, Dept Prosthodont & Periodontol, Bauru, SP, Brazil.
   [Riella, Leonardo] Harvard Med Sch, Massachusetts Gen Hosp, Div Nephrol, Boston, MA 02115 USA.
   [Torroni, Andrea; Coelho, Paulo G.] NYU, Hansjorg Wyss Dept Plast Surg, Langone Hlth Sch Med, New York, NY USA.
   [Witek, Lukasz] NYU, Dept Biomed Engn, Tandon Sch Engn, Brooklyn, NY USA.
   [Lopez, Christopher D.] Johns Hopkins Sch Med Baltimore, Dept Plast & Reconstruct Surg, Baltimore, MD USA.
   [Zambuzzi, Willian Fernando] UNESP Sao Paulo State Univ, Dept Chem & Biol Sci, Bioscience Inst IBB, Botucatu, SP, Brazil.
   [Coelho, Paulo G.] NYU, Dept Mech & Aerosp Engn, Tandon Sch Engn, Brooklyn, NY USA.
C3 New York University; Universidade de Sao Paulo; Universidade de Sao
   Paulo; Harvard University; Harvard Medical School; Harvard University
   Medical Affiliates; Massachusetts General Hospital; New York University;
   New York University; New York University Tandon School of Engineering;
   Johns Hopkins University; Johns Hopkins Medicine; Universidade Estadual
   Paulista; New York University; New York University Tandon School of
   Engineering
RP Coelho, PG (corresponding author), NYU, Coll Dent, Dept Biomat & Biomimet, New York, NY 10010 USA.; Coelho, PG (corresponding author), NYU, Dept Mech & Aerosp Engn, Tandon Sch Engn, Brooklyn, NY USA.
EM pc92@nyu.edu
RI Bergamo, Edmara/B-7635-2019; Bonfante, Estevam/F-7238-2012; Coelho,
   Paulo/B-2999-2014; Zambuzzi, Willian/ABD-8339-2020; Witek,
   Lukasz/AAU-5689-2020; Riella, Leonardo/AAC-8182-2019; Benalcazar Jalkh,
   Ernesto B./F-7316-2019; Zambuzzi, Willian/F-9519-2012
OI Benalcazar Jalkh, Ernesto B./0000-0002-7184-8485; Witek,
   Lukasz/0000-0003-1458-6527; Torroni, Andrea/0000-0002-6463-805X; Lopez,
   Christopher/0000-0001-8760-9545; Bonfante, Estevam
   A./0000-0001-6867-8350; Zambuzzi, Willian/0000-0002-4149-5965
FU Sao Paulo Research Foundation (FAPESP) [2012/19078-7, EMU 2016/18818-8,
   2018/03072-6, 2019/00452-5, 2019/08693-1]; Conselho Nacional de
   Desenvolvimento Cientifico e Tecnologico (CNPq) [304589/2017-9,
   434487/2018-0]
FX This research was supported by Sao Paulo Research Foundation (FAPESP),
   Grant No. 2012/19078-7, EMU 2016/18818-8, and scholarships 2018/03072-6,
   2019/00452-5, and 2019/08693-1; Conselho Nacional de Desenvolvimento
   Cientifico e Tecnologico (CNPq), Grant Nos 304589/2017-9 and
   434487/2018-0. Also, AdolfoCoelho DeOliveira Lopes is acknowledged for
   graphical design of Figures 1 and 3.
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NR 118
TC 67
Z9 67
U1 1
U2 48
PU CELL PRESS
PI CAMBRIDGE
PA 50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA
SN 1043-2760
EI 1879-3061
J9 TRENDS ENDOCRIN MET
JI Trends Endocrinol. Metab.
PD AUG
PY 2020
VL 31
IS 8
BP 596
EP 610
DI 10.1016/j.tem.2020.05.005
PG 15
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA NA7XN
UT WOS:000560031100005
PM 32591106
DA 2025-06-11
ER

PT J
AU Repossi, G
   Das, UN
   Eynard, AR
AF Repossi, Gaston
   Das, Undurti N.
   Renato Eynard, Aldo
TI Molecular Basis of the Beneficial Actions of Resveratrol
SO ARCHIVES OF MEDICAL RESEARCH
LA English
DT Review
DE Resveratrol; Polyunsaturated fatty acids; Brain-derived neurotrophic
   factor; Cytotoxic; Lipoxin A4; Metabolic syndrome; Cancer
ID POLYUNSATURATED FATTY-ACIDS; NEUROTROPHIC FACTOR; BISPHENOL-A;
   CHEMOSENSORY CELLS; OXIDATIVE STRESS; GENE-EXPRESSION; GUT MICROBIOTA;
   NITRIC-OXIDE; SIRT1; RECEPTOR
AB Resveratrol modulates the transcription factor NF-kappa B, cytochrome P450 isoenzyme CY-P1A1, expression and activity of cyclooxygenase (COX) enzymes, Fas/Fas ligand mediated apoptosis, p53, mTOR and cyclins and various phospho-diesterases resulting in an increase in cytosolic cAMP levels. Cyclic AMP, in turn, activates Epacl/CaMKKW AMPK/SIRTUPGC-1 alpha pathway that facilitates increased oxidation of fatty acids, mitochondrial respiration and their biogenesis and gluconeogenesis. Resveratrol triggers apoptosis of activated T cells and suppresses tumor necrosis factor-alpha (TNF-alpha), interleukin-17 (IL-17) and other pro-inflammatory molecules and inhibits expression of hypoxia inducible factor-1 alpha (HIF-1 alpha) and vascular endothelial growth factor (VEGF) that may explain its anti-inflammatory actions. Polyunsaturated fatty acids (PUFAs) and their anti-inflammatory metabolites lipoxin A4, resolvins, protectins and maresins have a significant role in obesity, type 2 diabetes mellitus (T2DM), metabolic syndrome and cancer. We observed that PUFAs (especially arachidonic acid, AA) and BDNF (brain-derived neurotrophic factor) protect against the cytotoxic actions of alloxan, streptozotocin, benzo(a)pyrene (BP) and doxorubicin. Thus, there is an overlap in the beneficial actions of resveratrol, PUFAs and BDNF suggesting that these molecules may interact and augment synthesis and action of each other. This is supported by the observation that resveratrol and PUFAs modulate gut microbiota and influence stem cell proliferation and differentiation. Since resveratrol is not easily absorbed from the gut it is likely that it may act on endocannabinoid and light, odor, and taste receptors located in the gut, which, in turn, convey their messages to the various organs via vagus nerve. (C) 2020 IMSS. Published by Elsevier Inc.
C1 [Repossi, Gaston; Renato Eynard, Aldo] Univ Nacl Cordoba, Fac Ciencias Med, Inst Invest Ciencias Salud, Catedra Biol Celular Histol & Embriol, Ciudad Univ, Cordoba, Argentina.
   [Das, Undurti N.] UND Life Sci, 221 NW 5th St, Battle Ground, WA 98604 USA.
C3 National University of Cordoba
RP Das, UN (corresponding author), UND Life Sci, 221 NW 5th St, Battle Ground, WA 98604 USA.
EM Undurti@hotmail.com
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NR 103
TC 70
Z9 76
U1 2
U2 27
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0188-4409
EI 1873-5487
J9 ARCH MED RES
JI Arch. Med. Res.
PD FEB
PY 2020
VL 51
IS 2
BP 105
EP 114
DI 10.1016/j.arcmed.2020.01.010
PG 10
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA LH8TX
UT WOS:000529057600001
PM 32111491
DA 2025-06-11
ER

PT J
AU Pal, R
   Bhadada, SK
AF Pal, Rimesh
   Bhadada, Sanjay K.
TI AGEs accumulation with vascular complications, glycemic control and
   metabolic syndrome: A narrative review
SO BONE
LA English
DT Review
DE Diabetes mellitus; Complications of diabetes; AGEs; Advanced glycation
   end-products
ID GLYCATION END-PRODUCTS; ENDOTHELIAL GROWTH-FACTOR; TYPE-2
   DIABETES-MELLITUS; FATTY LIVER-DISEASE; PERIPHERAL-NERVE; SERUM-LEVELS;
   SKIN AUTOFLUORESCENCE; INSULIN-RESISTANCE; INDUCED APOPTOSIS; RISK
AB Background: Multiple pathogenetic mechanisms are involved in the genesis of various microvascular and macrovascular complications of diabetes mellitus. Of all these, advanced glycation end products (AGEs) have been strongly implicated.Objectives: The present narrative review aims to summarize the available literature on the genesis of AGEs and their potential role in the causation of both micro-and macrovascular complications of diabetes mellitus.Results: Uncontrolled hyperglycemia triggers the formation of AGEs through non-enzymatic glycation reactions between reducing sugars and proteins, lipids, or nucleic acids. AGEs accumulate in bloodstream and bodily tissues under chronic hyperglycemia. AGEs create irreversible cross-linkages of various intra-and extracellular molecules and activate the receptor for advanced glycation end products (RAGE), which stimulates downstream signaling pathways that generate reactive oxygen species (ROS) and contribute to oxidative stress. Additionally, intracellular glycation of mitochondrial respiratory chain proteins by AGEs contributes to the further generation of ROS, which, in turn, sets a vicious cycle that further promotes the production of endogenous AGEs. Through these pathways, AGEs play a principal role in the pathogenesis of various diabetic complications, including diabetic retinopathy, nephropathy, neuropathy, bone disease, atherosclerosis and non-alcoholic fatty liver disease. Multiple clinical studies and meta-analyses have revealed a positive association between tissue or circulating levels of AGEs and development of various diabetic complications. Besides, exogenous AGEs, primarily those derived from diets, promote insulin resistance, obesity, and metabolic syndrome.Conclusions: AGEs, triggered by chronic hyperglycemia, play a pivotal role in the pathogenesis of various complications of diabetes mellitus.
C1 [Pal, Rimesh; Bhadada, Sanjay K.] Postgrad Inst Med Educ & Res PGIMER, Dept Endocrinol, Chandigarh 160012, India.
C3 Post Graduate Institute of Medical Education & Research (PGIMER),
   Chandigarh
RP Bhadada, SK (corresponding author), Postgrad Inst Med Educ & Res PGIMER, Dept Endocrinol, Chandigarh 160012, India.
EM bhadadask@rediffmail.com
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NR 102
TC 23
Z9 24
U1 4
U2 21
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 8756-3282
EI 1873-2763
J9 BONE
JI Bone
PD NOV
PY 2023
VL 176
AR 116884
DI 10.1016/j.bone.2023.116884
EA AUG 2023
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA R5QC6
UT WOS:001064887100001
PM 37598920
DA 2025-06-11
ER

PT J
AU Wahba, NS
   Ghareib, SA
   Abdel-Ghany, RH
   Abdel-Aal, M
   Alsemeh, AE
AF Wahba, Nehal S.
   Ghareib, Salah A.
   Abdel-Ghany, Rasha H.
   Abdel-Aal, Mohamed
   Alsemeh, Amira E.
TI Renoprotective effects of vitamin D3 supplementation in a rat model of
   metabolic syndrome
SO EUROPEAN JOURNAL OF NUTRITION
LA English
DT Article
DE MetS-induced nephropathy; Vitamin D3; RAAS; DPP-4; GLP-1; SIRT1; AMPK
ID RENIN-ANGIOTENSIN SYSTEM; DENSITY-LIPOPROTEIN CHOLESTEROL; CHROMOGENIC
   SYSTEM; ALDOSTERONE SYSTEM; URIC-ACID; ACTIVATION; SERUM; INFLAMMATION;
   FIBROSIS; PATHWAY
AB Purpose The study aimed to investigate the potential nephroprotective effects of vitamin D3 in metabolic syndrome (MetS) and the molecular basis of the underlying mechanisms of its action. Methods MetS was induced in adult male Wistar rat & x200f;s by adding fructose (10%) to every day drinking water and salt (3%) to the diet. Six weeks after fructose/salt consumption, fasting serum lipid profile and uric acid levels were determined, an oral glucose tolerance test (OGTT) was performed and kidney function was checked. MetS rats were then treated orally with vitamin D3 (10 mu g/kg/day) for 6 weeks. At the end of the study period (12 weeks), the OGTT test was reperformed, anthropometrical parameters were measured, urine, blood and tissue samples were collected and the animals were euthanised. Results The incidence of MetS was confirmed 6 weeks after fructose/salt consumption, when the rats exhibited significant weight gain, dyslipidemia, hyperuricemia, insulin resistance, hyperinsulinemia and impaired glucose tolerance. After 12 weeks, MetS rats displayed markedly declined renal function alongside with extravagant renal histopathological damages and interstitial fibrosis. Furthermore, significantly enhanced renal oxidative stress and inflammation were manifested. Vitamin D3 supplementation in MetS rats significantly reversed all the above-mentioned deleterious effects. Conclusion The study has indeed provided mounting evidence of the promising therapeutic potential of vitamin D3 against development and progression of MetS-induced nephropathy. A new insight has been introduced into the crucial role of dipeptidyl peptidase-4 inhibition and sirtuin-1/5 ' adenosine monophosphate-activated protein kinase activation in the renoprotective effects of vitamin D3.
C1 [Wahba, Nehal S.; Ghareib, Salah A.; Abdel-Ghany, Rasha H.; Abdel-Aal, Mohamed] Zagazig Univ, Fac Pharm, Dept Pharmacol & Toxicol, Zagazig, Egypt.
   [Alsemeh, Amira E.] Zagazig Univ, Fac Human Med, Dept Anat & Embryol, Zagazig, Egypt.
C3 Egyptian Knowledge Bank (EKB); Zagazig University; Egyptian Knowledge
   Bank (EKB); Zagazig University
RP Wahba, NS (corresponding author), Zagazig Univ, Fac Pharm, Dept Pharmacol & Toxicol, Zagazig, Egypt.
EM nehal.samir2011@yahoo.com
RI Wahba, Nehal/AAX-3271-2021; Alsemeh, Amira/LWH-9728-2024; Atteiah,
   salah/I-1537-2012; El-Aal, Mohamed/AAQ-4148-2020
OI Ghareib, Salah/0009-0005-5718-321X; Wahba, Nehal/0000-0002-8637-9204
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NR 73
TC 9
Z9 9
U1 0
U2 9
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1436-6207
EI 1436-6215
J9 EUR J NUTR
JI Eur. J. Nutr.
PD FEB
PY 2021
VL 60
IS 1
BP 299
EP 316
DI 10.1007/s00394-020-02249-6
EA APR 2020
PG 18
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA QD5RS
UT WOS:000528089000002
PM 32322970
DA 2025-06-11
ER

PT J
AU Wei, YJ
   Zhang, JF
   Li, ZG
   Gow, A
   Chung, KF
   Hu, M
   Sun, ZS
   Zeng, LM
   Zhu, T
   Jia, G
   Li, XQ
   Duarte, M
   Tang, XY
AF Wei, Yongjie
   Zhang, Junfeng (Jim)
   Li, Zhigang
   Gow, Andrew
   Chung, Kian Fan
   Hu, Min
   Sun, Zhongsheng
   Zeng, Limin
   Zhu, Tong
   Jia, Guang
   Li, Xiaoqian
   Duarte, Marlyn
   Tang, Xiaoyan
TI Chronic exposure to air pollution particles increases the risk of
   obesity and metabolic syndrome: findings from a natural experiment in
   Beijing
SO FASEB JOURNAL
LA English
DT Article
DE chronic inflammation; metabolic dysfunction; particulate matter
ID TUMOR-NECROSIS-FACTOR; INSULIN-RESISTANCE; ADIPOSE-TISSUE; MACROPHAGE
   INFILTRATION; MOUSE MODEL; INFLAMMATION; ASSOCIATION; INTERLEUKIN-10;
   PROTEIN; UPDATE
AB Epidemiologic evidence suggests that air pollution is a risk factor for childhood obesity. Limited experimental data have shown that early-life exposure to ambient particles either increases susceptibility to diet-induced weight gain in adulthood or increases insulin resistance, adiposity, and inflammation. However, no data have directly supported a link between air pollution and non-diet-induced weight increases. In a rodent model, we found that breathing Beijing's highly polluted air resulted in weight gain and cardiorespiratory and metabolic dysfunction. Compared to those exposed to filtered air, pregnant rats exposed to unfiltered Beijing air were significantly heavier at the end of pregnancy. At 8 wk old, the offspring prenatally and postnatally exposed to unfiltered air were significantly heavier than those exposed to filtered air. In both rat dams and their offspring, after continuous exposure to unfiltered air we observed pronounced histologic evidence for both perivascular and peribronchial inflammation in the lungs, increased tissue and systemic oxidative stress, dyslipidemia, and an enhanced proinflammatory status of epididymal fat. Results suggest that TLR2/4-dependent inflammatory activation and lipid oxidation in the lung can spill over systemically, leading to metabolic dysfunction and weight gain.Wei, Y., Zhang, J., Li, Z., Gow, A., Chung, K. F., Hu, M., Sun, Z., Zeng, L., Zhu, T., Jia, G., Li, X., Duarte, M., Tang, X. Chronic exposure to air pollution particles increases the risk of obesity and metabolic syndrome: findings from a natural experiment in Beijing.
C1 [Wei, Yongjie; Hu, Min; Zeng, Limin; Zhu, Tong; Tang, Xiaoyan] Peking Univ, Coll Environm Sci & Engn, State Key Joint Lab Environm Simulat & Pollut Con, Beijing 100871, Peoples R China.
   [Wei, Yongjie; Li, Zhigang; Li, Xiaoqian] Chinese Res Inst Environm Sci, State Key Lab Environm Criteria, Beijing, Peoples R China.
   [Wei, Yongjie; Li, Zhigang; Li, Xiaoqian] Chinese Res Inst Environm Sci, Risk Assessment & Environm Stand Inst, Beijing, Peoples R China.
   [Zhang, Junfeng (Jim); Duarte, Marlyn] Duke Univ, Nicholas Sch Environm, Box 90328,308 Res Dr, Durham, NC 27708 USA.
   [Zhang, Junfeng (Jim); Duarte, Marlyn] Duke Univ, Duke Global Hlth Inst, Durham, NC 27708 USA.
   [Zhang, Junfeng (Jim)] Duke Kunshan Univ, Kunshan, Peoples R China.
   [Gow, Andrew] Rutgers State Univ, Dept Pharmacol & Toxicol, Piscataway, NJ 08854 USA.
   [Chung, Kian Fan] Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, London, England.
   [Sun, Zhongsheng] Chinese Acad Sci, Beijing Inst Life Sci, Beijing, Peoples R China.
   [Jia, Guang] Peking Univ, Dept Occupat & Environm Hlth Sci, Sch Publ Hlth, Beijing 100871, Peoples R China.
C3 Peking University; Chinese Research Academy of Environmental Sciences;
   Chinese Research Academy of Environmental Sciences; Duke University;
   Duke University; Duke Kunshan University; Rutgers University System;
   Rutgers University New Brunswick; Imperial College London; Chinese
   Academy of Sciences; Peking University
RP Tang, XY (corresponding author), Peking Univ, Coll Environm Sci & Engn, State Key Joint Lab Environm Simulat & Pollut Con, Beijing 100871, Peoples R China.; Zhang, JF (corresponding author), Duke Univ, Nicholas Sch Environm, Box 90328,308 Res Dr, Durham, NC 27708 USA.; Zhang, JF (corresponding author), Duke Univ, Duke Global Hlth Inst, Durham, NC 27708 USA.
EM junfeng.zhang@duke.edu; xytang@pku.edu.cn
RI Zeng, Limin/D-3948-2013; Chung, Kian/B-1872-2012; Wei,
   Yongjie/G-1007-2010; Li, Zhigang/MHQ-3898-2025; Zhang,
   Junfeng/AAJ-9183-2020; Gow, Andrew/AAR-2309-2020; HU, Min/D-1037-2011;
   Sun, Zhongsheng/AAS-4883-2020; Gow, Andrew/N-8566-2013; Zhu,
   Tong/H-6501-2011
OI Gow, Andrew/0000-0003-0876-5158; Zhang, Junfeng/0000-0003-3759-6672;
   Zhu, Tong/0000-0002-2752-7924; Hu, Min/0000-0003-4816-9123
FU National Natural Science Foundation of China [21190051, 21477119]; State
   Key Joint Laboratory of Environment Simulation and Pollution Control
   [13K03ESPCP]; China Postdoctoral Science Foundation [201003010]
FX This work was supported in part by grants from the National Natural
   Science Foundation of China ( 21190051, 21477119), the Open Fund of the
   State Key Joint Laboratory of Environment Simulation and Pollution
   Control ( 13K03ESPCP), and the China Postdoctoral Science Foundation (
   201003010).
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   Bolton JL, 2012, FASEB J, V26, P4743, DOI 10.1096/fj.12-210989
   Brook RD, 2010, CIRCULATION, V121, P2331, DOI 10.1161/CIR.0b013e3181dbece1
   Charles BA, 2011, J CLIN ENDOCR METAB, V96, pE2018, DOI 10.1210/jc.2011-1497
   Chavey C, 2009, AGING-US, V1, P674, DOI 10.18632/aging.100064
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NR 23
TC 183
Z9 202
U1 1
U2 79
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
EI 1530-6860
J9 FASEB J
JI Faseb J.
PD JUN
PY 2016
VL 30
IS 6
BP 2115
EP 2122
DI 10.1096/fj.201500142
PG 8
WC Biochemistry & Molecular Biology; Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA DN2FA
UT WOS:000376878300006
PM 26891735
OA Green Published
DA 2025-06-11
ER

PT J
AU Watkins, DJ
   Peterson, KE
   Ferguson, KK
   Mercado-García, A
   Ortiz, MTY
   Cantoral, A
   Meeker, JD
   Téllez-Rojo, MM
AF Watkins, Deborah J.
   Peterson, Karen E.
   Ferguson, Kelly K.
   Mercado-Garcia, Adriana
   Ortiz, Marcela Tamayo y
   Cantoral, Alejandra
   Meeker, John D.
   Tellez-Rojo, Martha Maria
TI Relating Phthalate and BPA Exposure to Metabolism in Peripubescence: The
   Role of Exposure Timing, Sex, and Puberty
SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Article
ID URINARY BISPHENOL-A; PREGNANT-WOMEN; PPAR-GAMMA; TEMPORAL VARIABILITY;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; C-PEPTIDE; LEPTIN; ASSOCIATIONS;
   MARKERS
AB Context: Exposure to endocrine-disrupting chemicals during development may play a role in the increasing prevalence of metabolic syndrome and type 2 diabetes among children and adolescents by interfering with metabolic homeostasis.
   Objective: To explore associations between in utero and peripubertal urinary phthalate metabolite and bisphenol A (BPA) concentrations and markers of peripubertal metabolic homeostasis.
   Design: Early Life Exposure in Mexico to Environmental Toxicants (ELEMENT): a longitudinal cohort study of pregnant women in Mexico City and their offspring.
   Setting: Public maternity hospitals in Mexico City.
   Patients or Other Participants: Women recruited during pregnancy; offspring recruited for follow-up at age 8-14 years (n = 250).
   Interventions: None.
   Main Outcome Measures: Fasting serum c-peptide, IGF-1, leptin, and glucose concentrations among children at follow-up; calculated measures of insulin secretion and insulin resistance.
   Results: Phthalate metabolites and BPA were associated with metabolism biomarkers at age 8-14 years in patterns that varied by sex, pubertal status, and exposure timing. For example, in utero monoethyl phthalate was associated with lower insulin secretion among pubertal boys (P = .02) and higher leptin among girls (P = .04). In utero di-2-ethylhexyl phthlate was associated with higher IGF-1 among pubertal girls; peripubertal di-2-ethylhexyl phthlate was associated with higher IGF-1, insulin secretion, and resistance among prepubertal girls. In contrast, peripubertal dibutyl phthalate, monobenzyl phthalate, and mono-3-carboxypropyl phthalate were associated with lower IGF-1 among pubertal boys. Peripubertal BPA was associated with higher leptin in boys (P = .01).
   Conclusions: Considering the long-term health effects related to metabolic syndrome, additional research on exposure and metabolic outcomes across developmental periods and early adulthood is needed.
C1 [Watkins, Deborah J.; Ferguson, Kelly K.; Meeker, John D.] Univ Michigan, Dept Environm Hlth Sci, Sch Publ Hlth, Ann Arbor, MI 48109 USA.
   [Peterson, Karen E.] Univ Michigan, Dept Nutr Sci, Sch Publ Hlth, 1415 Washington Hts,1867 SPH I, Ann Arbor, MI 48109 USA.
   [Peterson, Karen E.] Univ Michigan, Ctr Human Growth & Dev, Ann Arbor, MI 48109 USA.
   [Peterson, Karen E.] Harvard Univ, Dept Nutr, TH Chan Sch Publ Hlth, Boston, MA 02115 USA.
   [Mercado-Garcia, Adriana; Ortiz, Marcela Tamayo y; Cantoral, Alejandra; Tellez-Rojo, Martha Maria] Natl Inst Publ Hlth, Ctr Nutr & Hlth Res, Cuernavaca 62508, Morelos, Mexico.
C3 University of Michigan System; University of Michigan; University of
   Michigan System; University of Michigan; University of Michigan System;
   University of Michigan; Harvard University; Harvard T.H. Chan School of
   Public Health; Instituto Nacional de Salud Publica
RP Peterson, KE (corresponding author), Univ Michigan, Dept Nutr Sci, Sch Publ Hlth, 1415 Washington Hts,1867 SPH I, Ann Arbor, MI 48109 USA.
EM karenep@umich.edu
RI tamayo-ortiz, Marcela/AAA-8985-2020; Cantoral, Alejandra/AAA-3615-2021;
   Ferguson, Kelly/C-3745-2019
OI Tamayo-Ortiz, Marcela/0000-0002-7018-3602; Meeker,
   John/0000-0001-8357-5085; Ferguson, Kelly/0000-0001-8467-3250; Tellez
   Rojo, Martha/0000-0003-3322-3334
FU National Institute for Environmental Health Sciences (NIHES)
   [P01ES022844, T32ES007062]; US Environmental Protection Agency (US EPA)
   [RD83543601]; National Institute of Environmental Health Sciences
   [P30ES017885, T32ES007062] Funding Source: NIH RePORTER
FX This work was supported by the following grants: P01ES022844 and
   T32ES007062 from the National Institute for Environmental Health
   Sciences (NIHES), and RD83543601 from the US Environmental Protection
   Agency (US EPA). It contents are solely the responsibility of the
   grantee and do not necessarily represent the official views of the US
   EPA. Further, the US EPA does not endrose the purchase any commerical
   products or services mentioned in the publication.
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NR 37
TC 59
Z9 67
U1 1
U2 15
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0021-972X
EI 1945-7197
J9 J CLIN ENDOCR METAB
JI J. Clin. Endocrinol. Metab.
PD JAN
PY 2016
VL 101
IS 1
BP 78
EP 87
DI 10.1210/jc.2015-2706
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA DN6UT
UT WOS:000377212700013
PM 26529628
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Mirrakhimov, AE
AF Mirrakhimov, Aibek E.
TI Chronic obstructive pulmonary disease and glucose metabolism: a bitter
   sweet symphony
SO CARDIOVASCULAR DIABETOLOGY
LA English
DT Review
DE COPD; Dysglycemia; Insulin resistance; Obesity; Metabolic syndrome;
   Diabetes mellitus endothelial dysfunction; Vasculopathy
ID TYPE-2 DIABETES-MELLITUS; BODY-MASS INDEX; C-REACTIVE PROTEIN; REDUCED
   LUNG-FUNCTION; AIR-FLOW OBSTRUCTION; INSPIRATORY MUSCLE PERFORMANCE;
   NUTRITION EXAMINATION SURVEY; NECROSIS-FACTOR-ALPHA; SLEEP-APNEA
   SYNDROME; FATTY LIVER-DISEASE
AB Chronic obstructive pulmonary disease, metabolic syndrome and diabetes mellitus are common and underdiagnosed medical conditions. It was predicted that chronic obstructive pulmonary disease will be the third leading cause of death worldwide by 2020. The healthcare burden of this disease is even greater if we consider the significant impact of chronic obstructive pulmonary disease on the cardiovascular morbidity and mortality. Chronic obstructive pulmonary disease may be considered as a novel risk factor for new onset type 2 diabetes mellitus via multiple pathophysiological alterations such as: inflammation and oxidative stress, insulin resistance, weight gain and alterations in metabolism of adipokines.
   On the other hand, diabetes may act as an independent factor, negatively affecting pulmonary structure and function. Diabetes is associated with an increased risk of pulmonary infections, disease exacerbations and worsened COPD outcomes. On the top of that, coexistent OSA may increase the risk for type 2 DM in some individuals. The current scientific data necessitate a greater outlook on chronic obstructive pulmonary disease and chronic obstructive pulmonary disease may be viewed as a risk factor for the new onset type 2 diabetes mellitus.
   Conversely, both types of diabetes mellitus should be viewed as strong contributing factors for the development of obstructive lung disease. Such approach can potentially improve the outcomes and medical control for both conditions, and, thus, decrease the healthcare burden of these major medical problems.
C1 Kyrgyz State Med Acad, Bishkek 720020, Kyrgyzstan.
C3 Ministry of Health - Kyrgyzstan; Kyrgyz State Medical Academy
RP Mirrakhimov, AE (corresponding author), Kyrgyz State Med Acad, Akhunbaev St 92, Bishkek 720020, Kyrgyzstan.
EM amirrakhimov1@gmail.com
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NR 259
TC 97
Z9 104
U1 3
U2 27
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1475-2840
J9 CARDIOVASC DIABETOL
JI Cardiovasc. Diabetol.
PD OCT 27
PY 2012
VL 11
AR 132
DI 10.1186/1475-2840-11-132
PG 26
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism
GA 038YJ
UT WOS:000311209700001
PM 23101436
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Adolphe, A
   Cook, LS
   Huang, X
AF Adolphe, Allen
   Cook, Linda S.
   Huang, Xun
TI A Cross-sectional Study of Intima-Media Thickness, Ethnicity, Metabolic
   Syndrome, and Cardiovascular Risk in 2268 Study Participants
SO MAYO CLINIC PROCEEDINGS
LA English
DT Article
ID CORONARY-HEART-DISEASE; B-MODE ULTRASOUND; CAROTID-ARTERY;
   ATHEROSCLEROSIS RISK; PROVISIONAL REPORT; OXIDATIVE STRESS; ALL-CAUSE;
   MORTALITY; IMPACT; MARKERS
AB OBJECTIVE: To describe the association between Intima-media thickness (IMT) and metabolic syndrome (MetS) and to examine If the addition of IMT to a traditional MetS definition adds value to the assessment of predicted cardiovascular disease (CVD) risk In a large multiethnic population.
   PARTICIPANTS AND METHODS: In this cross-sectional study, carotid IMT was measured In 2268 men and women as part of a wellness physical examination between August 1, 2000, and October 1, 2001. The wellness examination Included a fasting lipid panel, physical examination, and medical history. Mean IMT was described by sex, ethnicity, and the MetS. Predicted risk for CVD was determined with IMT as a component of the diagnostic criteria for MetS.
   RESULTS: Intima-media thickness Increased with each additional component of the MetS, Increasing from 0.516 mm for 0 components to 0.688 mm for 4 or more components (P<.001). In each ethnic group (non-Hispanic whites, blacks, Hispanics, and Asians), those with the MetS had higher mean IMT (increased by 0.084 mm to 0.134 mm) than those without MetS. The addition of IMT as a "new" component In the diagnosis of MetS allowed us to Identify 78 (3.4%) participants who were not previously diagnosed as having MetS but who had a high 10-year estimated risk of MetS as measured by the Framingham risk score (11.67%).
   CONCLUSION: The addition of IMT to the traditional criteria for the diagnosis of the MetS may help Identity Individuals who otherwise would not have been Identified to be at high risk of CVD.
C1 [Adolphe, Allen] Univ New Mexico, Dept Internal Med, Albuquerque, NM 87109 USA.
   [Cook, Linda S.] Univ New Mexico, Div Biostat & Epidemiol, Albuquerque, NM 87109 USA.
   [Huang, Xun] Univ New Mexico, Dept Math & Stat, Albuquerque, NM 87109 USA.
C3 University of New Mexico; University of New Mexico; University of New
   Mexico
RP Adolphe, A (corresponding author), Univ New Mexico, Dept Internal Med, 7801 Acad Rd NE, Albuquerque, NM 87109 USA.
EM aadolphe@salud.unm.edu
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NR 49
TC 36
Z9 45
U1 0
U2 4
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0025-6196
EI 1942-5546
J9 MAYO CLIN PROC
JI Mayo Clin. Proc.
PD MAR
PY 2009
VL 84
IS 3
BP 221
EP 228
DI 10.4065/84.3.221
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 416JW
UT WOS:000264003200003
PM 19252108
OA Green Published
DA 2025-06-11
ER

PT J
AU Kidman, CJ
   Mamotte, CDS
   Eynaud, MA
   Reinhardt, J
   Vongsvivut, J
   Tobin, MJ
   Hackett, MJ
   Graham, RM
AF Kidman, Clinton J.
   Mamotte, Cyril D. S.
   Eynaud, M. Adrien
   Reinhardt, Juliane
   Vongsvivut, Jitraporn
   Tobin, Mark J.
   Hackett, Mark J.
   Graham, Ross M.
TI Tracking biochemical changes induced by iron loading in AML12 cells with
   synchrotron live cell, time-lapse infrared microscopy
SO BIOCHEMICAL JOURNAL
LA English
DT Article
ID FATTY LIVER; OXIDATIVE STRESS; NONALCOHOLIC STEATOHEPATITIS; FTIR
   MICROSPECTROSCOPY; METABOLIC SYNDROME; DISEASE; DYSREGULATION;
   PROGRESSION; RADIATION; IMAGE
AB Hepatocytes are essential for maintaining the homeostasis of iron and lipid metabolis in mammals. Dysregulation of either iron or lipids has been linked with serious health consequences, including non-alcoholic fatty liver disease (NAFLD). Considered the hepatic manifestation of metabolic syndrome, NAFLD is characterised by dysregulated lipid metabolism leading to a lipid storage phenotype. Mild to moderate increases in hepatic iron have been observed in similar to 30% of individuals with NAFLD; however, direct observation of the mechanism behind this increase has remained elusive. To address this issue, we sought to determine the metabolic consequences of iron loading on cellular metabolism using live cell, time-lapse Fourier transform infrared (FTIR) microscopy utilising a synchrotron radiation source to track biochemical changes. The use of synchrotron FTIR is non-destructive and label-free, and allowed observation of spatially resolved, sub-cellular biochemical changes over a period of 8 h. Using this approach, we have demonstrated that iron loading in AML12 cells induced perturbation of lipid metabolism congruent with steatosis development. Iron-loaded cells had approximately three times higher relative ester carbonyl concentration compared with controls, indicating an accumulation of triglycerides. The methylene/methyl ratio qualitatively suggests the acyl chain length of fatty acids in iron-loaded cells increased over the 8 h period of monitoring compared with a reduction observed in the control cells. Our findings provide direct evidence that mild to moderate iron loading in hepatocytes drives de novo lipid synthesis, consistent with a role for iron in the initial hepatic lipid accumulation that leads to the development of hepatic steatosis.
C1 [Kidman, Clinton J.; Mamotte, Cyril D. S.; Graham, Ross M.] Curtin Univ, Sch Pharm & Biomed Sci, Perth, WA 6102, Australia.
   [Kidman, Clinton J.; Mamotte, Cyril D. S.; Eynaud, M. Adrien; Hackett, Mark J.; Graham, Ross M.] Curtin Univ, Curtin Hlth Innovat Res Inst, Perth, WA 6102, Australia.
   [Reinhardt, Juliane; Vongsvivut, Jitraporn; Tobin, Mark J.] ANSTO Australian Synchrotron, 800 Blackburn Rd, Clayton, Vic 3168, Australia.
   [Hackett, Mark J.] Curtin Univ, Sch Mol & Life Sci, Perth, WA 6845, Australia.
   [Reinhardt, Juliane] Lawrence Berkeley Natl Lab, Adv Light Source, 1 Cyclotron Rd Berkeley, Berkeley, CA 94720 USA.
C3 Curtin University; Curtin University; Curtin University; United States
   Department of Energy (DOE); Lawrence Berkeley National Laboratory
RP Kidman, CJ; Graham, RM (corresponding author), Curtin Univ, Sch Pharm & Biomed Sci, Perth, WA 6102, Australia.; Kidman, CJ; Graham, RM (corresponding author), Curtin Univ, Curtin Hlth Innovat Res Inst, Perth, WA 6102, Australia.
EM Clinton.kidman@postgrad.curtin.edu.au; rmgraham@curtin.edu.au
RI Mamotte, Cyril/AAF-9603-2020; Tobin, Mark/B-8208-2015
OI Mamotte, Cyril/0000-0003-1831-3921; Vongsvivut,
   Jitraporn/0000-0003-0699-3464; Tobin, Mark/0000-0003-1862-0649; Eynaud,
   Adrien/0000-0003-1857-7484; hackett, mark/0000-0002-3296-7270
FU Australian Synchrotron Merit Access programme [AS1/IRM/15866,
   AS191/XFM/14353]; Curtin University; Australian Government Research
   Training Programme scholarship
FX This work was undertaken on the IRM and XFM beamlines at the Australian
   Synchrotron, part of ANSTO, and funded by the Australian Synchrotron
   Merit Access programme (AS1/IRM/15866 and AS191/XFM/14353) and Curtin
   University. C.J.K. is the recipient of an Australian Government Research
   Training Programme scholarship.
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NR 49
TC 3
Z9 3
U1 1
U2 10
PU PORTLAND PRESS LTD
PI LONDON
PA 5TH FLR, 90 HIGH HOLBORN, LONDON WC1V 6LJ, ENGLAND
SN 0264-6021
EI 1470-8728
J9 BIOCHEM J
JI Biochem. J.
PD MAR
PY 2021
VL 478
IS 6
BP 1227
EP 1239
DI 10.1042/BCJ20200653
PG 13
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA RA1LO
UT WOS:000631179600003
PM 33616158
OA hybrid
DA 2025-06-11
ER

PT J
AU Ferenc, K
   Pietrzak, P
   Wierzbicka, M
   Matyba, P
   Grzesiuk, E
   Gajewski, Z
   Zabielski, R
AF Ferenc, K.
   Pietrzak, P.
   Wierzbicka, M.
   Matyba, P.
   Grzesiuk, E.
   Gajewski, Z.
   Zabielski, R.
TI ALTERATIONS IN THE LIVER OF INTRAUTERINE GROWTH RETARDED PIGLETS MAY
   PREDISPOSE TO DEVELOPMENT OF INSULIN RESISTANCE AND OBESITY IN LATER
   LIFE
SO JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
LA English
DT Article
DE inflammation; intrauterine growth retardation; liver receptors;
   adipokines; Kupffer cells; insulin resistance; obesity
ID DEPENDENT DIABETES-MELLITUS; NEWBORN PIGS; GASTROINTESTINAL-TRACT;
   UNCOUPLING PROTEIN-3; GLUCOSE TRANSPORTERS; METABOLIC SYNDROME;
   SKELETAL-MUSCLE; SMALL-INTESTINE; KUPFFER CELLS; FETAL-GROWTH
AB Intrauterine growth retardation (IUGR) leads to increased predisposition to metabolic syndrome in adult life but the mechanisms remain obscure. Considering a significant number of functional similarities, IUGR piglets appear to be a good model to study the development of this syndrome in humans. The aim of the present study was to investigate the ultrastructure and proteomic profile of the liver in IUGR pig neonates to discover early markers of predisposition to obesity and insulin resistance. In our study intestine and liver tissue samples were investigated in 7 day old IUGR and normal body weight (NBW) littermate piglets using histometry, mass spectrometry, in-tissue cytometry analysis and confocal microscopy. Compared to NBW, the liver in IUGR neonates was characterized by a significantly enhanced ratio of Kupffer cells to hepatocytes and insulin receptor abundance as well as higher percentages of cells expressing receptors for adipokines (resistin and adiponectin), increased expression of TNF-alpha (as marker of inflammation), and increased expression of insulin receptor and uncoupling protein 3 (UCP3). Moreover, NBW and IUGR differed in proteomic profile, including protein metabolism (proteasomes, cathepsin D, phermitin, phosphoglucomutase), carbohydrate metabolism (hexokinase 1, phosphoglucokinase, galactokinase, aldolase B, glucose-6-phosphate isomerase), oxidative stress and chromatin organization and DNA uptake (histones, lamin a/c). Reduction of hepatocyte numbers concomitant with significant modifications of expression of key hormones and enzymes for protein and carbohydrate metabolism in IUGR neonates may predispose to insulin resistance and obesity in adult life.
C1 [Ferenc, K.; Pietrzak, P.; Wierzbicka, M.; Matyba, P.; Gajewski, Z.; Zabielski, R.] Warsaw Univ Life Sci, Fac Vet Med, Vet Res Ctr, 100 Nowoursynowska St, PL-02797 Warsaw, Poland.
   [Ferenc, K.; Pietrzak, P.; Wierzbicka, M.; Matyba, P.; Gajewski, Z.; Zabielski, R.] Warsaw Univ Life Sci, Fac Vet Med, Ctr Biomed Res, Dept Large Anim Dis Clin, 100 Nowoursynowska St, PL-02797 Warsaw, Poland.
   Polish Acad Sci, Inst Biochem & Biophys, Dept Mol Biol, Warsaw, Poland.
C3 Warsaw University of Life Sciences; Warsaw University of Life Sciences;
   Polish Academy of Sciences; Institute of Biochemistry & Biophysics -
   Polish Academy of Sciences
RP Zabielski, R (corresponding author), Warsaw Univ Life Sci, Fac Vet Med, Vet Res Ctr, 100 Nowoursynowska St, PL-02797 Warsaw, Poland.; Zabielski, R (corresponding author), Warsaw Univ Life Sci, Fac Vet Med, Ctr Biomed Res, Dept Large Anim Dis Clin, 100 Nowoursynowska St, PL-02797 Warsaw, Poland.
EM rzabielski@icloud.com
RI Gajewski, Zdzislaw/N-1481-2016
OI Grzesiuk, Elzbieta/0000-0002-7833-7602; Ferenc,
   Karolina/0000-0002-0100-9328; Zabielski, Romuald/0000-0003-1725-9783;
   Gajewski, Zdzislaw/0000-0001-8779-5050
FU National Research Center [UMO-2015/17/N/NZ4/02836]; Polish-Norwegian
   Research Fund [POL-NOR/196258/59/2013]; KNOW (Leading National Research
   Centre) Scientific Consortium 'Healthy Animal - Safe Food', of Ministry
   of Science and Higher Education [05-1/KNOW2/2015 KNOW]
FX This work was supported by National Research Center
   (UMO-2015/17/N/NZ4/02836), Polish-Norwegian Research Fund Grant
   POL-NOR/196258/59/2013, and KNOW (Leading National Research Centre)
   Scientific Consortium 'Healthy Animal - Safe Food', decision of Ministry
   of Science and Higher Education No. 05-1/KNOW2/2015 KNOW.
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NR 55
TC 11
Z9 13
U1 0
U2 9
PU POLISH PHYSIOLOGICAL SOC
PI GRZEGORZECKA
PA JAGIELLONIAN UNIV SCHOOL MED, INST PHYSIOLOGY, 31-531 KRAKOW, 16
   GRZEGORZECKA, POLAND
SN 0867-5910
J9 J PHYSIOL PHARMACOL
JI J. Physiol. Pharmacol.
PD APR
PY 2018
VL 69
IS 2
DI 10.26402/jpp.2018.2.06
PG 8
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA GN2TO
UT WOS:000438853400006
PM 29920475
DA 2025-06-11
ER

PT J
AU Zeng, J
   Fan, JG
   Francque, SM
AF Zeng, Jing
   Fan, Jian-Gao
   Francque, Sven M.
TI Therapeutic management of metabolic dysfunction associated steatotic
   liver disease
SO UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
LA English
DT Review
DE management; MASH; MASLD; metabolic dysfunction associated steatotic
   liver disease; metabolic syndrome lifestyle; NAFLD; NASH; therapy
ID NONALCOHOLIC STEATOHEPATITIS; MECHANISMS; RISK
AB The incidence and prevalence of non-alcoholic fatty liver disease (NAFLD) have been steadily increasing worldwide, with a huge societal and economic burden. Recently, NAFLD and non-alcoholic steatohepatitis have been renamed and redefined as metabolic dysfunction associated steatotic liver disease (MASLD) and steatohepatitis (Metabolic Dysfunction Associated Steatohepatitis (MASH)), which result from an imbalance between metabolic and inflammatory stress (mainly as a consequence of adipose tissue dysfunction and insulin resistance) and the defence and repair mechanisms of the steatotic liver. Once MASLD progresses to end-stage of liver disease, treatment efficacy becomes limited and may require liver transplantation. Early detection and intervention are crucial. Lifestyle modification is consequently the cornerstone of its management. Timely consideration of bariatric surgeries should be given to patients meeting specific criteria. A multidisciplinary approach is warranted, starting from the concept that MASLD/MASH is at the centre of the cardiovascular-liver-metabolic syndrome. In some cases, pharmacological treatment can complement lifestyle modification. Several drugs used to treat the cardiometabolic co-morbidities have some potential efficacy in slowing Down disease progression, and some have demonstrated efficacy on histological endpoints that are likely to translate into long-term clinical benefits. Optimising the use of these drugs within their licenced indications is thus paramount for patients with MASLD. Several MASH-specific drugs are on the horizon and are likely to enrich our therapeutic armamentarium in the near future, particularly in non-cirrhotic stages of the disease. Much work still needs to be done to understand the specific features of MASH cirrhosis and develop efficacious treatments for this disease stage.
   image
C1 [Zeng, Jing; Fan, Jian-Gao] Shanghai Jiao Tong Univ, Xinhua Hosp, Sch Med, Dept Gastroenterol, Shanghai 200092, Peoples R China.
   [Zeng, Jing; Fan, Jian-Gao] Shanghai Key Lab Pediat Gastroenterol & Nutr, Shanghai 200092, Peoples R China.
   [Francque, Sven M.] Antwerp Univ Hosp, Dept Gastroenterol Hepatol, Drie Eikenstraat 655, B-2650 Edegem, Belgium.
   [Francque, Sven M.] Univ Antwerp, Fac Med & Hlth Sci, InflaMed Ctr Excellence, Lab Expt Med & Paediat Translat Sci Inflammat & Im, Univ Pl 1, B-2610 Antwerp, Belgium.
C3 Shanghai Jiao Tong University; University of Antwerp; University of
   Antwerp
RP Fan, JG (corresponding author), Shanghai Jiao Tong Univ, Xinhua Hosp, Sch Med, Dept Gastroenterol, Shanghai 200092, Peoples R China.; Fan, JG (corresponding author), Shanghai Key Lab Pediat Gastroenterol & Nutr, Shanghai 200092, Peoples R China.; Francque, SM (corresponding author), Antwerp Univ Hosp, Dept Gastroenterol Hepatol, Drie Eikenstraat 655, B-2650 Edegem, Belgium.; Francque, SM (corresponding author), Univ Antwerp, Fac Med & Hlth Sci, InflaMed Ctr Excellence, Lab Expt Med & Paediat Translat Sci Inflammat & Im, Univ Pl 1, B-2610 Antwerp, Belgium.
EM fanjiangao@xinhuamed.com.cn; sven.francque@uza.be
RI ; Francque, sven/E-4526-2017
OI Zeng, Jing/0000-0001-7764-155X; Francque, sven/0000-0002-7527-4714
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NR 44
TC 40
Z9 42
U1 16
U2 33
PU JOHN WILEY & SONS LTD
PI CHICHESTER
PA THE ATRIUM, SOUTHERN GATE, CHICHESTER PO19 8SQ, W SUSSEX, ENGLAND
SN 2050-6406
EI 2050-6414
J9 UNITED EUR GASTROENT
JI United European Gastroenterol. J.
PD MAR
PY 2024
VL 12
IS 2
SI SI
BP 177
EP 186
DI 10.1002/ueg2.12525
EA JAN 2024
PG 10
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA LL2D0
UT WOS:001138424700001
PM 38193865
OA hybrid
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Zheng, JP
   Yuan, XB
   Zhang, C
   Jia, PY
   Jiao, SM
   Zhao, XM
   Yin, H
   Du, YG
   Liu, HT
AF Zheng, Junping
   Yuan, Xubing
   Zhang, Chen
   Jia, Peiyuan
   Jiao, Siming
   Zhao, Xiaoming
   Yin, Heng
   Du, Yuguang
   Liu, Hongtao
TI N-Acetylcysteine alleviates gut dysbiosis and glucose metabolic
   disorder in high-fat diet-fed mice
SO JOURNAL OF DIABETES
LA English
DT Article
DE Akkermansia; gut microbiota; lipopolysaccharide; metabolic syndrome;
   N-acetylcysteine
ID MOLECULAR-MECHANISM; INSULIN-RESISTANCE; BIOFILM FORMATION;
   ACETYL-CYSTEINE; MICROBIOTA; OBESITY; INFLAMMATION; ASSOCIATION;
   BENEFITS; GROWTH
AB Background: N-Acetylcysteine (NAC), an antioxidative reagent for clinical diseases, shows potential in the treatment of diabetes and other metabolic diseases. However, it is unknown how NAC modulates the gut microbiota of mice with metabolic syndrome. The aim of the present study was to demonstrate the preventive effect of NAC on intestinal dysbiosis and glucose metabolic disorder.
   Methods: Mice (C57BL/6J strain) were fed either a normal chow diet (NCD), NCD plus NAC, a high-fat diet (HFD), or HFD plus NAC for 5 months, after which glucose levels, circulating endotoxins and key metabolism-related proteins were determined. Fecal samples were analyzed by 16S rRNA sequencing. A novel analysis was performed to predict functional changes in gut microbiota. In addition, Spearman's correlation analysis was performed between metabolic biomarkers and bacterial abundance.
   Results: Treatment with NAC significantly reversed the glucose intolerance, fasting glucose concentrations, and gains in body weight and plasma endotoxin in HFD-fed mice. Further, NAC upregulated occludin and mucin glycoprotein levels in the proximal colon of HFD-treated mice. Noticeably, NAC promoted the growth of beneficial bacteria (i.e. Akkermansia, Bifidobacterium, Lactobacillus and Allobaculum) and decreased populations of diabetes-related genera, including Desulfovibrio and Blautia. In addition, NAC may affect the metabolic pathways of intestinal bacteria, including lipopolysaccharide biosynthesis, oxidative stress, and bacterial motility. Finally, the modified gut microbiota was closely associated with the metabolic changes in NAC-treated HFD-fed mice.
   Conclusions: N-Acetylcysteine may be a potential drug to prevent glucose metabolic disturbances by reshaping the structure of the gut microbiota.
C1 [Zheng, Junping; Zhao, Xiaoming; Yin, Heng] Chinese Acad Sci, Dalian Inst Chem Phys, Liaoning Prov Key Lab Carbohydrates, Dalian, Peoples R China.
   [Zheng, Junping; Yuan, Xubing] Univ Chinese Acad Sci, Beijing, Peoples R China.
   [Zheng, Junping; Yuan, Xubing; Zhang, Chen; Jia, Peiyuan; Jiao, Siming; Du, Yuguang; Liu, Hongtao] Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing, Peoples R China.
   [Zheng, Junping; Yuan, Xubing; Zhang, Chen; Jia, Peiyuan; Jiao, Siming; Du, Yuguang; Liu, Hongtao] Chinese Acad Sci, Inst Proc Engn, Key Lab Biopharmaceut Prod & Formulat Engn, Beijing, Peoples R China.
   [Liu, Hongtao] Zhengzhou Inst Emerging Ind Technol, Zhengzhou, Henan, Peoples R China.
C3 Chinese Academy of Sciences; Dalian Institute of Chemical Physics, CAS;
   Chinese Academy of Sciences; University of Chinese Academy of Sciences,
   CAS; Chinese Academy of Sciences; Institute of Process Engineering, CAS;
   Institute of Process Engineering, CAS; Chinese Academy of Sciences;
   Zhengzhou Institute of Emerging Industrial Technology
RP Liu, HT (corresponding author), Chinese Acad Sci, State Key Lab Biochem Engn, Beijing 100190, Peoples R China.; Liu, HT (corresponding author), Chinese Acad Sci, Key Lab Biopharmaceut Prod & Formulat Engn, PLA, Inst Proc Engn, Beijing 100190, Peoples R China.
EM liuhongtao@ipe.ac.cn
RI xiaoming, zhao/JTS-6757-2023; Zheng, Johny/AAX-8898-2020; Yin,
   Heng/AAJ-3890-2020
OI zhang, chen/0000-0001-7175-1424; Zheng, Junping/0000-0002-9134-572X
FU National Natural Science Foundation of China [31570801, 31500747,
   31672077]; National Programs for High Technology Research and
   Development (863 Programs) [2014AA093604]; CAS Youth Innovation
   Promotion Association [2015144]
FX The authors are grateful for support from the National Natural Science
   Foundation of China (No. 31570801, 31500747 and 31672077), National
   Programs for High Technology Research and Development (863 Programs;
   2014AA093604), and the CAS Youth Innovation Promotion Association (No.
   2015144).
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NR 47
TC 39
Z9 40
U1 0
U2 49
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1753-0393
EI 1753-0407
J9 J DIABETES
JI J. Diabetes
PD JAN
PY 2019
VL 11
IS 1
BP 32
EP 45
DI 10.1111/1753-0407.12795
PG 14
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA HC5UP
UT WOS:000451868200006
PM 29845722
DA 2025-06-11
ER

PT J
AU Ji, Y
   Park, S
   Park, H
   Hwang, E
   Shin, H
   Pot, B
   Holzapfel, WH
AF Ji, Yosep
   Park, Soyoung
   Park, Haryung
   Hwang, Eunchong
   Shin, Hyeunkil
   Pot, Bruno
   Holzapfel, Wilhelm H.
TI Modulation of Active Gut Microbiota by Lactobacillus
   rhamnosus GG in a Diet Induced Obesity Murine Model
SO FRONTIERS IN MICROBIOLOGY
LA English
DT Article
DE 16S rDNA analysis; 16S rRNA analysis; gut microbiota; obesity; LGG
ID RIBOSOMAL-RNA; PROBIOTICS; INFLAMMATION; COMMUNITIES; METABOLISM;
   ADIPOSITY; STRESS; MICE; PCR
AB Gut microbiota play a key role in the development of metabolic disorders. Defining and correlating structural shifts in gut microbial assemblages with conditions related to metabolic syndrome have, however, been proven difficult. Results from 16S genomic DNA and 16S ribosomal RNA analyses of fecal samples may differ widely, leading to controversial information on the whole microbial community and metabolically active microbiota. Using a C57BL/6J murine model, we compared data from 16S genomic DNA and ribosomal RNA of the fecal microbiota. The study included three groups of experimental animals comprising two groups with high fat diet induced obesity (DIO) while a third group (control) received a low fat diet. One of the DIO groups was treated with the probiotic Lactobacillus rhamnosus GG (LGG). Compared to the data obtained by DNA analysis, a significantly higher abundance of OTUs was accounted for by RNA analysis. Moreover, rRNA based analysis showed a modulation of the active gut microbial population in the DIO group receiving LGG, thus reflecting a change in the induced obesity status of the host. As one of the most widely studied probiotics the functionality of LGG has been linked to the alleviation of metabolic syndrome, and, in some cases, to an impact on the microbiome. Yet, it appears that no study has reported thus far on modulation of the active microbiota by LGG treatment. It is postulated that the resulting impact on calorie consumption affects weight gain concomitantly with modulation of the functional structure of the gut microbial population. Using the 16S rRNA based approach therefore decisively increased the precision of gut microbiota metagenome analysis.
C1 [Ji, Yosep; Park, Soyoung; Park, Haryung; Hwang, Eunchong; Holzapfel, Wilhelm H.] Handong Global Univ, Grad Sch Adv Green Energy & Environm, Pohang, South Korea.
   [Shin, Hyeunkil] Handong Global Univ, Sch Life Sci, Pohang, South Korea.
   [Pot, Bruno] Vrije Univ Brussel, Dept Bioengn Sci, Res Grp Ind Microbiol & Food Biotechnol, Brussels, Belgium.
C3 Handong Global University; Handong Global University; Vrije Universiteit
   Brussel
RP Holzapfel, WH (corresponding author), Handong Global Univ, Grad Sch Adv Green Energy & Environm, Pohang, South Korea.
EM wilhelm@woodapple.net
RI Park, Grace/U-1673-2018
FU Bio & Medical Technology Development Program of the National Research
   Foundation (NRF) - Korean Government [2016M3A9A5923160]; Strategic
   Initiative for Microbiomes in Agriculture and Food [916002-02-1-CG000]
FX This study was supported by the Bio & Medical Technology Development
   Program of the National Research Foundation (NRF) funded by Korean
   Government (2016M3A9A5923160) and the Strategic Initiative for
   Microbiomes in Agriculture and Food (916002-02-1-CG000).
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NR 66
TC 41
Z9 43
U1 0
U2 26
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-302X
J9 FRONT MICROBIOL
JI Front. Microbiol.
PD APR 10
PY 2018
VL 9
AR 710
DI 10.3389/fmicb.2018.00710
PG 13
WC Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Microbiology
GA GC1TD
UT WOS:000429564000001
PM 29692770
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Lee, J
   Kim, Y
   Friso, S
   Choi, SW
AF Lee, Jooho
   Kim, Yuri
   Friso, Simonetta
   Choi, Sang-Woon
TI Epigenetics in non-alcoholic fatty liver disease
SO MOLECULAR ASPECTS OF MEDICINE
LA English
DT Review
DE Epigenetics; Non-alcoholic fatty liver disease (NAFLD); Non-alcoholic
   steatohepatitis (NASH); DNA methylation; Histone modifications; microRNA
ID HEPATOCELLULAR-CARCINOMA; CIRCULATING MICRORNAS; HEPATIC STEATOSIS; DNA
   METHYLATION; IN-VIVO; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   ACID-METABOLISM; NATURAL-HISTORY; DOWN-REGULATION
AB Non-alcoholic fatty liver disease (NAFLD), a common hepatic disorder ranging from simple steatosis through steatohepatitis to fibrosis and cirrhosis, is an emerging health concern. NAFLD is a pathologic condition characterizedby the buildup of extra fat in liver cells that is not caused by alcohol consumption. Excess hepatic fat accumulation results from increased delivery of triglycerides (TG) to the liver or conversion of surplus carbohydrates to TG. Importantly, a subgroup of NAFLD results in hepatocellular injury and inflammation, which is referred to as non-alcoholic steatohepatitis (NASH), and may progress to irreversible cirrhosis and hepatocellular carcinoma (HCC). NAFLD shares, in part, the common pathogenesis of metabolic syndrome including obesity, hyperlipidemia, insulin resistance, mitochondrial damage, oxidative stress response, and the release of inflammatory cytokines. Epigenetics, an inheritable phenomenon that affects gene expression without altering the DNA sequence, provides a new perspective on the pathogenesis of NAFLD. Reversible epigenetic changes take place at the transcriptional level and provide a phenotypic connection between the host and environment. An accumulating body of evidence suggests the importance of epigenetic roles in NAFLD, which in turn can be identified as potential therapeutic targets and non-invasive biomarkers of NAFLD. It is anticipated that the epigenetic modifiers in NAFLD may provide novel molecular indicators that can determine not only the initial risk but also the disease progression and prognosis. In the present review, we update the roles of epigenetics as pathologic mechanisms, therapeutic targets and biomarkers in NAFLD. (C) 2016 Elsevier Ltd. All rights reserved.
C1 [Lee, Jooho] CHA Univ Med & Sci, CHA Bundang Med Ctr, Div Gastroenterol & Hepatol, Dept Internal Med, Seongnam 13496, South Korea.
   [Kim, Yuri] Ewha Womans Univ, Dept Nutr Sci & Food Management, Seoul 03760, South Korea.
   [Friso, Simonetta] Univ Verona, Sch Med, I-37134 Verona, Italy.
   [Choi, Sang-Woon] CHA Univ Med & Sci, Chaum Life Ctr, 442 Dosan Daero, Seoul 06062, South Korea.
C3 Ewha Womans University; University of Verona
RP Choi, SW (corresponding author), CHA Univ Med & Sci, Chaum Life Ctr, 442 Dosan Daero, Seoul 06062, South Korea.
EM sang.choi@cha.ac.kr
RI Gim, Yuri/JNZ-3445-2023; Friso, Simonetta/K-4715-2016
FU Korea Food Research Institute [E0150302]; Korea Healthcare Technology R
   D project; Ministry for Health, Welfare AMP; Family Affairs, Republic of
   Korea [HI13C1398]
FX This study was supported by a grant from the Korea Food Research
   Institute (E0150302) and by a grant of the Korea Healthcare Technology
   R& D project, Ministry for Health, Welfare & Family Affairs, Republic of
   Korea (HI13C1398). All authors have no conflict of interest.
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NR 140
TC 101
Z9 109
U1 1
U2 56
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0098-2997
EI 1872-9452
J9 MOL ASPECTS MED
JI Mol. Asp. Med.
PD APR
PY 2017
VL 54
BP 78
EP 88
DI 10.1016/j.mam.2016.11.008
PG 11
WC Biochemistry & Molecular Biology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Research & Experimental Medicine
GA EP3KU
UT WOS:000397282000008
PM 27889327
DA 2025-06-11
ER

PT J
AU Rosa, DD
   Grzeskowiak, LM
   Ferreira, CLLF
   Fonseca, ACM
   Reis, SA
   Dias, MM
   Siqueira, NP
   Silva, LL
   Neves, CA
   Oliveira, LL
   Machado, ABF
   Peluzio, MDG
AF Rosa, Damiana D.
   Grzeskowiak, Lukasz M.
   Ferreira, Celia L. L. F.
   Fonseca, Ana Carolina M.
   Reis, Sandra A.
   Dias, Mariana M.
   Siqueira, Nathane P.
   Silva, Leticia L.
   Neves, Clovis A.
   Oliveira, Leandro L.
   Machado, Alessandra B. F.
   Peluzio, Maria do Carmo G.
TI Kefir reduces insulin resistance and inflammatory cytokine expression in
   an animal model of metabolic syndrome
SO FOOD & FUNCTION
LA English
DT Article
ID ADIPOSE-TISSUE; OXIDATIVE STRESS; DOWN-REGULATION; FERMENTED MILK; GUT
   MICROBIOTA; BLOOD-PRESSURE; PROBIOTICS; GLUCOSE; OBESITY; RATS
AB There is growing evidence that kefir can be a promising tool in decreasing the risk of many diseases, including metabolic syndrome (MetS). The aim of the present study was to evaluate the effect of kefir supplementation in the diet of Spontaneously Hypertensive Rats (SHR) in which MetS was induced with monosodium glutamate (MSG), and to determine its effect on metabolic parameters, inflammatory and oxidation marker expression and glycemic index control. Thirty animals were used in this experiment. For the induction of MetS, twenty two-day-old male SHR received five consecutive intradermal injections of MSG. For the Negative Control, ten newborn male SHR received intradermal injections of saline solution (0.9% saline solution). After weaning, animals received standard diet and water ad libitum until reaching 3 months old, for the development of MetS. They were then divided into three groups (n = 10): negative control (NC, 1 mL saline solution per day), positive control (PC, 1 mL saline solution per day) and the Kefir group (1 mL kefir per day). Feeding was carried out by gavage for 10 weeks and the animals received standard food and water ad libitum. Obesity, insulin resistance, pro-and anti-inflammatory markers, and the histology of pancreatic and adipose tissues were among the main variables evaluated. Compared to the PC group, kefir supplementation reduced plasma triglycerides, liver lipids, liver triglycerides, insulin resistance, fasting glucose, fasting insulin, thoracic circumference, abdominal circumference, products of lipid oxidation, pro-inflammatory cytokine expression (IL-1 beta) and increased anti-inflammatory cytokine expression (IL-10). The present findings indicate that kefir has the potential to benefit the management of MetS.
C1 [Rosa, Damiana D.; Grzeskowiak, Lukasz M.; Fonseca, Ana Carolina M.; Reis, Sandra A.; Dias, Mariana M.; Siqueira, Nathane P.; Silva, Leticia L.; Peluzio, Maria do Carmo G.] Univ Fed Vicosa, Dept Nutr & Hlth, Vicosa, MG, Brazil.
   [Ferreira, Celia L. L. F.] Univ Fed Vicosa, Dept Food Technol, Vicosa, MG, Brazil.
   [Neves, Clovis A.; Oliveira, Leandro L.] Univ Fed Vicosa, Dept Gen Biol, Vicosa, MG, Brazil.
   [Machado, Alessandra B. F.] Univ Fed Juiz de Fora, Dept Microbiol Immunol & Parasitol, Juiz De Fora, Brazil.
C3 Universidade Federal de Vicosa; Universidade Federal de Vicosa;
   Universidade Federal de Vicosa; Universidade Federal de Juiz de Fora
RP Rosa, DD (corresponding author), Univ Fed Vicosa, Dept Nutr & Hlth, Vicosa, MG, Brazil.
EM ddinizrosa@gmail.com
RI Reis, Sandra/Y-9152-2019; Dias, Mariana/LZH-6634-2025; Rosa,
   Damiana/KRO-9187-2024; Licursi de Oliveira, Leandro/D-3616-2009
OI PELUZIO, MARIA DO CARMO GOUVEIA/0000-0003-4665-7043; Diniz Rosa,
   Damiana/0000-0002-2106-456X; Grzeskowiak, Lukasz/0000-0002-0831-4077; de
   Moura e Dias, Mariana/0000-0003-0822-0721; Licursi de Oliveira,
   Leandro/0000-0003-4353-7011
FU Foundation of Research Support of the Minas Gerais State - Brazil
   (FAPEMIG-CDS) [APQ-00763-12]; National Council of Technological and
   Scientific Development (CNPq - Brazil); Coordination for Enhancement of
   Higher Education Personnel (CAPES - Brazil)
FX We would like to thank the Foundation of Research Support of the Minas
   Gerais State - Brazil (FAPEMIG-CDS - APQ-00763-12) for financial support
   of the project. DDR obtained a scientific grant from the National
   Council of Technological and Scientific Development (CNPq - Brazil). LMG
   was supported by the Coordination for Enhancement of Higher Education
   Personnel (CAPES - Brazil).
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NR 70
TC 48
Z9 49
U1 1
U2 38
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PD AUG 1
PY 2016
VL 7
IS 8
BP 3390
EP 3401
DI 10.1039/c6fo00339g
PG 12
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA DT3XP
UT WOS:000381414800006
PM 27384318
DA 2025-06-11
ER

PT J
AU Huang, CL
   Wu, YW
   Wu, CC
   Hwang, JJ
   Yang, WS
AF Huang, Chi-Lun
   Wu, Yen-Wen
   Wu, Chih-Cheng
   Hwang, Juey-Jen
   Yang, Wei-Shiung
TI Serum Angiopoietin-Like Protein 2 Concentrations Are Independently
   Associated with Heart Failure
SO PLOS ONE
LA English
DT Article
ID CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; ADIPONECTIN; RISK; RESISTIN;
   ANGPTL2; OBESITY; PATHOGENESIS; INFLAMMATION; DYSFUNCTION
AB Objective
   Angiopoietin-like protein 2 (ANGPTL2), which is mainly expressed from adipose tissue, is demonstrated to be involved in obesity, metabolic syndrome, and atherosclerosis. Because several adipocytokines are known to be associated with heart failure (HF), here we investigated the association of ANGPTL2 and HF in Taiwanese subjects.
   Methods and Results
   A total of 170 symptomatic HF patients and 130 age-and sex-matched controls were enrolled from clinic. The echocardiography was analyzed in each patient, and stress myocardial perfusion study was performed for clinical suspicion of coronary artery disease. Detailed demographic information, medications, and biochemical data were recorded. Circulating adipocytokines, including tumor necrosis factor-alpha (TNF-alpha), adiponectin, adipocyte fatty acid-binding protein (A-FABP) and ANGPTL2, were analyzed. Compared with the control group subjects, serum ANGPTL2 concentrations were significantly higher in HF group patients. In correlation analyses, ANGPTL2 level was positively correlated to creatinine, fasting glucose, triglyceride, hsCRP, TNF-alpha, NT-proBNP and A-FABP levels, and negatively correlated with HDL-C and left ventricular ejection fraction. In multiple regression analysis, A-FABP, hsCRP, and HDL-C levels remained as independent predictors for ANGPTL2 level. To determine the association between serum ANGPTL2 concentrations and HF, multivariate logistic regression analyses were performed with subjects divided into tertiles by ANGPTL2 levels. For the subjects with ANGPTL2 levels in the highest tertile, their risk of HF was about 2.97 fold (95% CI = 1.24-7.08, P = 0.01) higher than those in the lowest tertile.
   Conclusion
   Our results demonstrate a higher circulating ANGPTL2 level in patients with HF, and the upregulating ANGPTL2 levels might be associated with metabolic derangements and inflammation.
C1 [Huang, Chi-Lun] Minist Hlth & Welf, Taoyuan Gen Hosp, Dept Internal Med, Taoyuan, Taiwan.
   [Huang, Chi-Lun; Wu, Yen-Wen; Hwang, Juey-Jen; Yang, Wei-Shiung] Natl Taiwan Univ Hosp, Dept Internal Med, Taipei 100, Taiwan.
   [Wu, Yen-Wen] Natl Taiwan Univ Hosp, Dept Nucl Med, Taipei, Taiwan.
   [Wu, Yen-Wen] Far Eastern Mem Hosp, Dept Nucl Med, New Taipei City, Taiwan.
   [Wu, Yen-Wen] Far Eastern Mem Hosp, Cardiovasc Med Ctr Cardiol, New Taipei City, Taiwan.
   [Wu, Yen-Wen] Natl Yang Ming Univ, Sch Med, Taipei 112, Taiwan.
   [Wu, Chih-Cheng] Natl Taiwan Univ Hosp, Hsin Chu Branch, Dept Internal Med, Hsinchu, Taiwan.
   [Yang, Wei-Shiung] Natl Taiwan Univ, Grad Inst Clin Med, Coll Med, Taipei 10764, Taiwan.
C3 National Taiwan University; National Taiwan University Hospital;
   National Taiwan University; National Taiwan University Hospital; Far
   Eastern Memorial Hospital; Far Eastern Memorial Hospital; National Yang
   Ming Chiao Tung University; National Taiwan University; National Taiwan
   University Hospital; National Taiwan University
RP Wu, YW (corresponding author), Natl Taiwan Univ Hosp, Dept Internal Med, Taipei 100, Taiwan.
EM wsyang@ntu.edu.tw; wuyw0502@gmail.com
RI Liu, Chun-Yu/I-4358-2015; Li, Tsai-Chung/P-2052-2015
OI YANG, WEI-SHIUNG/0000-0001-5087-373X; WU, YEN-WEN/0000-0003-1520-1166;
   Hwang, Juey-Jen/0000-0001-6437-0455; WU, CHIH-CHENG/0000-0002-9690-6573
FU Taoyuan General Hospital [PTH10412]; National Taiwan University Hospital
   [HCH102-28]; National Science Council of Taiwan [MOST
   101-2314-B-418-012-MY3]
FX This study was supported by research grants funded by Taoyuan General
   Hospital (PTH10412), National Taiwan University Hospital (HCH102-28),
   and National Science Council of Taiwan (MOST 101-2314-B-418-012-MY3).
   The funders had no role in study design, data collection and analysis,
   decision to publish, or preparation of the manuscript.
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NR 34
TC 26
Z9 27
U1 0
U2 6
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD SEP 23
PY 2015
VL 10
IS 9
AR e0138678
DI 10.1371/journal.pone.0138678
PG 11
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA CS1BM
UT WOS:000361797500094
PM 26397985
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU van der Heijden, RA
   Sheedfar, F
   Morrison, MC
   Hommelberg, PPH
   Kor, D
   Kloosterhuis, NJ
   Gruben, N
   Youssef, SA
   de Bruin, A
   Hofker, MH
   Kleemann, R
   Koonen, DPY
   Heeringa, P
AF van der Heijden, Roel A.
   Sheedfar, Fareeba
   Morrison, Martine C.
   Hommelberg, Pascal P. H.
   Kor, Danny
   Kloosterhuis, Niels J.
   Gruben, Nanda
   Youssef, Sameh A.
   de Bruin, Alain
   Hofker, Marten H.
   Kleemann, Robert
   Koonen, Debby P. Y.
   Heeringa, Peter
TI High-fat diet induced obesity primes inflammation in adipose tissue
   prior to liver in C57BL/6j mice
SO AGING-US
LA English
DT Article
DE obesity; metabolic syndrome; insulin resistance; inflammation; adipose
   tissue; NASH; liver
ID INSULIN-RESISTANCE; NONALCOHOLIC STEATOHEPATITIS; METABOLIC SYNDROME;
   GLUCOSE-TOLERANCE; HEPATIC STEATOSIS; DISEASE; AGE; EXPRESSION;
   RAPAMYCIN; STRESS
AB Metabolic inflammation in adipose tissue and the liver is frequently observed as a result of diet-induced obesity in human and rodent studies. Although the adipose tissue and the liver are both prone to become chronically inflamed with prolonged obesity, their individual contribution to the development of metabolic inflammation remains speculative. Thus, we aimed to elucidate the sequence of inflammatory events in adipose and hepatic tissues to determine their contribution to the development of metabolic inflammation and insulin resistance (IR) in diet-induced obesity. To confirm our hypothesis that adipose tissue (AT) inflammation is initiated prior to hepatic inflammation, C57BL/6J male mice were fed a low-fat diet (LFD; 10% kcal fat) or high-fat diet (HFD; 45% kcal fat) for either 24, 40 or 52 weeks. Lipid accumulation and inflammation was measured in AT and liver. Glucose tolerance was assessed and plasma levels of glucose, insulin, leptin and adiponectin were measured at various time points throughout the study. With HFD, C57BL/6j mice developed a progressive obese phenotype, accompanied by IR at 24 and 40 weeks of HFD, but IR was attenuated after 52 weeks of HFD. AT inflammation was present after 24 weeks of HFD, as indicated by the increased presence of crown-like structures and up-regulation of pro-inflammatory genes Tnf, Il1 beta, Mcp1 and F4/80. As hepatic inflammation was not detected until 40 weeks of HFD, we show that AT inflammation is established prior to the development of hepatic inflammation. Thus, AT inflammation is likely to have a greater contribution to the development of IR compared to hepatic inflammation.
C1 [van der Heijden, Roel A.; Kor, Danny; Hofker, Marten H.; Heeringa, Peter] Univ Groningen, Univ Med Ctr Groningen, Dept Pathol & Med Biol, Sect Med Biol, Groningen, Netherlands.
   [Sheedfar, Fareeba; Hommelberg, Pascal P. H.; Kloosterhuis, Niels J.; Gruben, Nanda; de Bruin, Alain; Koonen, Debby P. Y.] Univ Groningen, Univ Med Ctr Groningen, Dept Pediat, Mol Genet Sect, Groningen, Netherlands.
   [Morrison, Martine C.; Kleemann, Robert] Netherlands Org Appl Sci Res TNO, Dept Metab Hlth Res, Leiden, Netherlands.
   [Youssef, Sameh A.; de Bruin, Alain] Univ Utrecht, Fac Vet Med, Dept Pathobiol, Dutch Mol Pathol Ctr, Utrecht, Netherlands.
   [Sheedfar, Fareeba] Radboud Univ Nijmegen, Med Ctr, Dept Physiol, NL-6525 ED Nijmegen, Netherlands.
C3 University of Groningen; University of Groningen; Utrecht University;
   Radboud University Nijmegen
RP Koonen, DPY (corresponding author), Univ Groningen, Univ Med Ctr Groningen, Dept Pediat, Mol Genet Sect, Groningen, Netherlands.
EM d.p.y.koonen@umcg.nl
RI de Bruin, Alain/AAL-9195-2020; Heeringa, Peter/A-6008-2009; Morrison,
   Martine/C-3168-2014
OI Heeringa, Peter/0000-0001-8684-763X; de Bruin,
   Alain/0000-0001-8579-2649; Koonen, Debby/0000-0002-1881-8826; Morrison,
   Martine/0000-0003-4996-943X; , Fareeba/0000-0002-1315-1903
FU Top Institute for Food and Nutrition (TIFN); Center for Translational
   Molecular Medicine (CTMM) project PREDICCt [01C-104]; Dutch Heart
   Foundation; Dutch Diabetes Research Foundation; Dutch Kidney Foundation
   (PREDICCt); TNO research program "Personalized Medicine (Therapie Op
   Maat)"; Graduate School for Drug Exploration (GUIDE), University of
   Groningen
FX The study was funded by Top Institute for Food and Nutrition (TIFN), a
   public-private partnership on pre-competitive research in food and
   nutrition and by the Center for Translational Molecular Medicine (CTMM)
   project PREDICCt (grant 01C-104) and Dutch Heart Foundation, Dutch
   Diabetes Research Foundation and Dutch Kidney Foundation (PREDICCt), and
   the TNO research program "Personalized Medicine (Therapie Op Maat)". It
   was also financially supported by the Graduate School for Drug
   Exploration (GUIDE), University of Groningen. The funders had no role in
   study design, data collection and analysis, decision to publish, or
   preparation of the manuscript.
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NR 45
TC 211
Z9 228
U1 0
U2 26
PU IMPACT JOURNALS LLC
PI ALBANY
PA 6211 TIPTON HOUSE, STE 6, ALBANY, NY 12203 USA
SN 1945-4589
J9 AGING-US
JI Aging-US
PD APR
PY 2015
VL 7
IS 4
BP 256
EP 268
DI 10.18632/aging.100738
PG 13
WC Cell Biology; Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Geriatrics & Gerontology
GA CH4XM
UT WOS:000354036900006
PM 25979814
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Feldman, F
   Koudoufio, M
   Sané, AT
   Marcil, V
   Sauvé, MF
   Butcher, J
   Patey, N
   Martel, C
   Spahis, S
   Duan, HN
   Figeys, D
   Desjardins, Y
   Stintzi, A
   Levy, E
AF Feldman, Francis
   Koudoufio, Mireille
   Sane, Alain Theophile
   Marcil, Valerie
   Sauve, Mathilde Foisy
   Butcher, James
   Patey, Natalie
   Martel, Catherine
   Spahis, Schohraya
   Duan, Haonan
   Figeys, Daniel
   Desjardins, Yves
   Stintzi, Alain
   Levy, Emile
TI Therapeutic Potential of Cranberry Proanthocyanidins in Addressing the
   Pathophysiology of Metabolic Syndrome: A Scrutiny of Select Mechanisms
   of Action
SO ANTIOXIDANTS
LA English
DT Article
DE obesity; dyslipidemia; inflammation; hepatic steatosis; gut-liver axis;
   intestinal microbiota
ID INSULIN-RESISTANCE; AKKERMANSIA-MUCINIPHILA; GUT MICROBIOTA; ADIPOCYTE
   DIFFERENTIATION; EXTRACT; OBESITY; FAT; METFORMIN; HEALTH; ACTIVATION
AB Metabolic syndrome (MetS) constitutes a spectrum of interconnected conditions comprising obesity, dyslipidemia, hypertension, and insulin resistance (IR). While a singular, all-encompassing treatment for MetS remains elusive, an integrative approach involving tailored lifestyle modifications and emerging functional food therapies holds promise in preventing its multifaceted manifestations. Our main objective was to scrutinize the efficacy of cranberry proanthocyanidins (PAC, 200 mg/kg/day for 12 weeks) in mitigating MetS pathophysiology in male mice subjected to standard Chow or high-fat/high-fructose (HFHF) diets while unravelling intricate mechanisms. The administration of PAC, in conjunction with an HFHF diet, significantly averted obesity, evidenced by reductions in body weight, adiposity across various fat depots, and adipocyte hypertrophy. Similarly, PAC prevented HFHF-induced hyperglycemia and hyperinsulinemia while also lessening IR. Furthermore, PAC proved effective in alleviating key risk factors associated with cardiovascular diseases by diminishing plasma saturated fatty acids, as well as levels of triglycerides, cholesterol, and non-HDL-C levels. The rise in adiponectin and drop in circulating levels of inflammatory markers showcased PAC's protective role against inflammation. To better clarify the mechanisms behind PAC actions, gut-liver axis parameters were examined, showing significant enhancements in gut microbiota composition, microbiota-derived metabolites, and marked reductions in intestinal and hepatic inflammation, liver steatosis, and key biomarkers associated with endoplasmic reticulum (ER) stress and lipid metabolism. This study enhances our understanding of the complex mechanisms underlying the development of MetS and provides valuable insights into how PAC may alleviate cardiometabolic dysfunction in HFHF mice.
C1 [Feldman, Francis; Koudoufio, Mireille; Sane, Alain Theophile; Marcil, Valerie; Sauve, Mathilde Foisy; Spahis, Schohraya; Levy, Emile] St Justine Univ Hlth Ctr, Azraeli Res Ctr, Montreal, PQ H3T 1C5, Canada.
   [Feldman, Francis; Koudoufio, Mireille; Marcil, Valerie; Sauve, Mathilde Foisy; Levy, Emile] Univ Montreal, Dept Nutr, Montreal, PQ H3T 1A8, Canada.
   [Butcher, James; Duan, Haonan; Figeys, Daniel; Stintzi, Alain] Univ Ottawa, Sch Pharmaceut Sci, Ottawa Inst Syst Biol, Ottawa, ON K1H 1M5, Canada.
   [Butcher, James; Stintzi, Alain] Univ Ottawa, Dept Biochem Microbiol & Immunol, Ottawa, ON K1H 8M5, Canada.
   [Patey, Natalie] Univ Montreal, Dept Pathol & Cell Biol, Montreal, PQ H3C 3J7, Canada.
   [Martel, Catherine] Montreal Heart Inst Res Ctr, Res Ctr, Montreal, PQ H1T 1C8, Canada.
   [Martel, Catherine] Univ Montreal, Fac Med, Dept Med, Montreal, PQ H3T 1J4, Canada.
   [Spahis, Schohraya] Univ Montreal, Dept Biochem & Mol Med, Montreal, PQ H3C 3J7, Canada.
   [Desjardins, Yves] Laval Univ, Inst Nutr & Funct Foods, Quebec City, PQ G1V 4L3, Canada.
C3 Universite de Montreal; University of Ottawa; University of Ottawa;
   Universite de Montreal; Universite de Montreal; Universite de Montreal;
   Universite de Montreal; Laval University
RP Levy, E (corresponding author), St Justine Univ Hlth Ctr, Azraeli Res Ctr, Montreal, PQ H3T 1C5, Canada.; Levy, E (corresponding author), Univ Montreal, Dept Nutr, Montreal, PQ H3T 1A8, Canada.
EM francis.feldman@umontreal.ca; mireille.koudoufio@umontreal.ca;
   sanealaintheo@gmail.com; valerie.marcil@umontreal.ca;
   mathilde.foisy.sauve@umontreal.ca; jbutcher@uottawa.ca;
   natalie.patey.med@ssss.gouv.qc.ca; catherine.martel.9@umontreal.ca;
   schohraya.spahis.hsj@ssss.gouv.qc.ca; hduan084@uottawa.ca;
   dfigeys@uottawa.ca; yves.desjardins@fsaa.ulaval.ca; astintzi@uottawa.ca;
   emile.levy@umontreal.ca
RI Butcher, James/AAC-8339-2020
FU JA deSeve Research Chair in nutrition; Government of Canada through
   Genome Canada; Ontario Genomics Institute [OGI-149]; Ontario Ministry of
   Economic Development and Innovation [13440]; NSERC-Symrise Chair on
   prebiotic effect of fruit polyphenols [401240871]
FX The current work was supported by the JA deSeve Research Chair in
   nutrition (E.L.), the Government of Canada through Genome Canada, the
   Ontario Genomics Institute (OGI-149), the Ontario Ministry of Economic
   Development and Innovation (Project 13440) (E.L., A.S.), and the
   NSERC-Symrise Chair on prebiotic effect of fruit polyphenols (401240871)
   (E.L. and Y.D.).
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NR 103
TC 0
Z9 0
U1 0
U2 0
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD FEB 26
PY 2025
VL 14
IS 3
AR 268
DI 10.3390/antiox14030268
PG 26
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA 0QE1Q
UT WOS:001453381100001
PM 40227220
OA gold
DA 2025-06-11
ER

PT J
AU Alami, M
   Boumezough, K
   Khalil, A
   Ramchoun, M
   Boulbaroud, S
   Fulop, T
   Morvaridzadeh, M
   Berrougui, H
   Hashimoto, Y
AF Alami, Mehdi
   Boumezough, Kaoutar
   Khalil, Abdelouahed
   Ramchoun, Mhamed
   Boulbaroud, Samira
   Fulop, Tamas
   Morvaridzadeh, Mojgan
   Berrougui, Hicham
   Hashimoto, Yoshitaka
TI The Modulatory Bioeffects of Pomegranate (Punica granatum L.)
   Polyphenols on Metabolic Disorders: Understanding Their Preventive Role
   against Metabolic Syndrome
SO NUTRIENTS
LA English
DT Review
DE Punica granatum L.; pharmacokinetic; metabolic disorders; dyslipidaemia;
   diabetes mellitus; obesity; antihyperlipidemic; antihyperglycemic;
   atherosclerosis
ID INTIMA-MEDIA THICKNESS; SEED OIL; JUICE CONSUMPTION; PPAR-GAMMA;
   DIABETIC-PATIENTS; OXIDATIVE STRESS; BLOOD-PRESSURE; ELLAGIC ACID;
   FLOWER EXTRACT; GLUCOSE-HOMEOSTASIS
AB Modern research achievements support the health-promoting effects of natural products and diets rich in polyphenols. Pomegranate (PG) (Punica granatum L.) contains a considerable number of bioactive compounds that exert a broad spectrum of beneficial biological activities, including antimicrobial, antidiabetic, antiobesity, and atheroprotective properties. In this context, the reviewed literature shows that PG intake might reduce insulin resistance, cytokine levels, redox gene expression, blood pressure elevation, vascular injuries, and lipoprotein oxidative modifications. The lipid parameter corrective capabilities of PG-ellagitannins have also been extensively reported to be significantly effective in reducing hyperlipidemia (TC, LDL-C, VLDL-C, and TAGs), while increasing plasma HDL-C concentrations and improving the TC/HDL-C and LDL-C/HDL-C ratios. The health benefits of pomegranate consumption seem to be acheived through the amelioration of adipose tissue endocrine function, fatty acid utilization, GLUT receptor expression, paraoxonase activity enhancement, and the modulation of PPAR and NF-kappa B. While the results from animal experiments are promising, human findings published in this field are inconsistent and are still limited in several aspects. The present review aims to discuss and provide a critical analysis of PG's bioeffects on the components of metabolic syndrome, type-2 diabetes, obesity, and dyslipidemia, as well as on certain cardiovascular-related diseases. Additionally, a brief overview of the pharmacokinetic properties, safety, and bioavailability of PG-ellagitannins is included.
C1 [Alami, Mehdi; Boumezough, Kaoutar; Ramchoun, Mhamed; Boulbaroud, Samira; Berrougui, Hicham] Univ Sultan Moulay Slimane, Polydisciplinary Fac, Dept Biol, Beni Mellal 23020, Morocco.
   [Alami, Mehdi; Khalil, Abdelouahed; Fulop, Tamas; Morvaridzadeh, Mojgan; Berrougui, Hicham] Univ Sherbrooke, Fac Med & Biol Sci, Dept Med, Geriatr Serv, Sherbrooke, PQ J1H 4N4, Canada.
C3 Sultan Moulay Slimane University of Beni Mellal; University of
   Sherbrooke
RP Berrougui, H (corresponding author), Univ Sultan Moulay Slimane, Polydisciplinary Fac, Dept Biol, Beni Mellal 23020, Morocco.; Berrougui, H (corresponding author), Univ Sherbrooke, Fac Med & Biol Sci, Dept Med, Geriatr Serv, Sherbrooke, PQ J1H 4N4, Canada.
EM halamimehdi@gmail.com; kaoutarrosa1@gmail.com; a.khalil@usherbrooke.ca;
   ramchoun_10@yahoo.fr; sboulbaroud@gmail.com; tamas.fulop@usherbrooke.ca;
   mojgan.morvaridzadeh@usherbrooke.ca; hichamberg@gmail.com
RI Morvaridzadeh, Mojgan/GLU-6418-2022
OI Khalil, Abdelouahed/0000-0003-0817-3160; berrougui,
   hicham/0000-0002-0546-6534
FU Agence Nationale des Plantes Mdicinales et Aromatiques; Centre National
   de Recherche Scientifique et Technique and Universit Sultan Moulay
   Slimane
FX No Statement Available
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NR 114
TC 4
Z9 4
U1 7
U2 18
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD DEC
PY 2023
VL 15
IS 23
AR 4879
DI 10.3390/nu15234879
PG 23
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA AI1C5
UT WOS:001117735100001
PM 38068738
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Sedik, AA
   Amer, AA
AF Sedik, Ahmed A.
   Amer, Asmaa A.
TI Modulatory Effects of Cilostazol; an Nrf2/HO-1 activator against NAFLD
   in Rats Confirmed by Molecular Docking and FTIR Studies
SO EGYPTIAN JOURNAL OF CHEMISTRY
LA English
DT Article
DE NAFLD; Cilostazol; Nrf2; HO; FTIR; molecular docking
ID FATTY LIVER-DISEASE; METABOLIC SYNDROME; CRYSTAL-STRUCTURE;
   NITRIC-OXIDE; NEPHROTOXICITY; COMPLICATIONS; ANTIPLATELET; INHIBITION;
   COMPLEX; SYSTEM
AB Nonalcoholic fatty liver disease (NAFLD) is a multi-etiological hepato-metabolic syndrome. No effective drugs have been settled for the effective therapy of NAFLD. Our study was conducted to evaluate the modulatory effects of cilostazol (CILO, 50 and 100 mg/kg.p.o.) against NAFLD induced by high fat diet rich in cholesterol (HFD- CH) for 10 weeks. Forty male Sprague dawely rats were divided into 4 groups (10 rat / group). Normal control group supplied with normal chow diet. Control positive group received HFD- CH for 10 weeks. In addition, two CILO groups received (CILO, 50 and 100 mg/kg.p.o.) concurrently with HFDCH. Our findings revealed that CILO at a dose level (100 mg/kg) showed promising results in reducing fasting glucose and insulin levels. Moreover, it could reduce the elevated inflammatory cytokines, hepatic lipids and oxidative stress biomarkers. In addition, CILO succeeded to restore the total protein levels and activate nuclear factor erythroid-related factor2/heme oxygenase1 (Nrf2/HO-1) activity. Furthermore, administration of CILO for NAFLD rats succeeded to show corrected and normalized FTIR spectra. We also investigated the plausible binding interactions of CILO with various biological targets using a molecular docking approach, and the results showed that CILO had an excellent docking energy score and significant binding interactions with the core amino acids involved in the active pocket for the enzymes studied. This study confirmed that CILO exerted a new intervention for NAFLD due to its complementary anti-hyperlipidemic, anti-inflammatory, and antioxidant potential, which was achieved through Nrf2/HO-1 activation.
C1 [Sedik, Ahmed A.] Natl Res Ctr, Med Res & Clin Studies Inst, Dept Pharmacol, Cairo 12622, Egypt.
   [Amer, Asmaa A.] Natl Res Ctr, Pharmaceut & Drug Ind Res Inst, Dept Pharmacognosy, Cairo 12622, Egypt.
C3 Egyptian Knowledge Bank (EKB); National Research Centre (NRC); Egyptian
   Knowledge Bank (EKB); National Research Centre (NRC)
RP Sedik, AA (corresponding author), Natl Res Ctr, Med Res & Clin Studies Inst, Dept Pharmacol, Cairo 12622, Egypt.
EM aa.sedik@gmail.com
RI Amer, Asmaa/AGY-7727-2022; sedik, ahmed/AAE-5529-2022
OI sedik, ahmed/0000-0002-0237-1900; Amer, Asmaa Ahmed/0000-0001-7208-3288
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NR 67
TC 2
Z9 2
U1 0
U2 3
PU NATL INFORM & DOCUMENT CENTRE
PI CAIRO
PA NIDOC DOKKI, CAIRO, 00000, EGYPT
SN 0449-2285
EI 2357-0245
J9 EGYPT J CHEM
JI Egypt. J. Chem.
PD DEC
PY 2022
VL 65
IS 12
BP 493
EP 508
DI 10.21608/EJCHEM.2022.138491.6091
PG 16
WC Chemistry, Multidisciplinary
WE Emerging Sources Citation Index (ESCI)
SC Chemistry
GA 8J3GW
UT WOS:000922309300042
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Durak, A
   Akkus, E
   Canpolat, AG
   Tuncay, E
   Corapcioglu, D
   Turan, B
AF Durak, Aysegul
   Akkus, Erman
   Canpolat, Asena Gokcay
   Tuncay, Erkan
   Corapcioglu, Demet
   Turan, Belma
TI Glucagon-like peptide-1 receptor agonist treatment of high carbohydrate
   intake-induced metabolic syndrome provides pleiotropic effects on
   cardiac dysfunction through alleviations in electrical and intracellular
   Ca<SUP>2+</SUP> abnormalities and mitochondrial dysfunction
SO CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
LA English
DT Article
DE arrhythmia; electrical activity; insulin resistance; ion-homeostasis;
   sodium-calcium exchanger
ID LEFT-VENTRICULAR FUNCTION; HEART-FAILURE; RYANODINE RECEPTOR; OXIDATIVE
   STRESS; PKA PHOSPHORYLATION; NATRIURETIC-PEPTIDE; GLP-1 RECEPTOR;
   GLUCOSE-UPTAKE; LIRAGLUTIDE; CALCIUM
AB The pleiotropic effects of glucagon-like peptide-1 receptor (GLP-1R) agonists on the heart have been recognised in obese or diabetic patients. However, little is known regarding the molecular mechanisms of these agonists in cardioprotective actions under metabolic disturbances. We evaluated the effects of GLP-1R agonist liraglutide treatment on left ventricular cardiomyocytes from high-carbohydrate induced metabolic syndrome rats (MetS rats), characterised with insulin resistance and cardiac dysfunction with a long-QT. Liraglutide (0.3 mg/kg for 4 weeks) treatment of MetS rats significantly reversed long-QT, through a shortening the prolonged action potential duration and recovering inhibited K+-currents. We also determined a significant recovery in the leaky sarcoplasmic reticulum (SR) and high cytosolic Ca2+-level, which are confirmed with a full recovery in activated Na+/Ca2+-exchanger currents (I-NCX). Moreover, the liraglutide treatment significantly reversed the depolarised mitochondrial membrane potential (MMP), increased production of oxidant markers, and cellular acidification together with the depressed ATP production. Our light microscopy analysis of isolated cardiomyocytes showed marked recoveries in the liraglutide-treated MetS group such as marked reverses in highly dilated T-tubules and SR-mitochondria junctions. Moreover, we determined a significant increase in depressed GLUT4 protein level in liraglutide-treated MetS group, possibly associated with recovery in casein kinase 2 alpha. Overall, the study demonstrated a molecular mechanism of liraglutide-induced cardioprotection in MetS rats, at most, via its pleiotropic effects, such as alleviation in the electrical abnormalities, Ca2+-homeostasis, and mitochondrial dysfunction in ventricular cardiomyocytes.
C1 [Durak, Aysegul; Tuncay, Erkan; Turan, Belma] Ankara Univ, Fac Med, Dept Biophys, Ankara, Turkey.
   [Akkus, Erman] Ankara Univ, Fac Med, Dept Internal Med, Ankara, Turkey.
   [Canpolat, Asena Gokcay; Corapcioglu, Demet] Ankara Univ, Fac Med, Dept Endocrinol & Metab, Ankara, Turkey.
   [Turan, Belma] Lokman Hekim Univ, Fac Med, Dept Biophys, Ankara, Turkey.
C3 Ankara University; Ankara University; Ankara University; Lokman Hekim
   University
RP Turan, B (corresponding author), Lokman Hekim Univ, Fac Med, Dept Biophys, Ankara, Turkey.
EM belma.turan@medicine.ankara.edu.tr
RI TUNCAY, ERKAN/AAG-8065-2020; durak, aysegul/AAA-7647-2022; GÖKÇAY
   CANPOLAT, ASENA/AAH-1447-2020; TURAN, Belma/AAG-8084-2020; Akkus,
   Erman/ADT-1337-2022; ÇORAPÇIOĞLU, DEMET/AAG-9344-2020
OI Gokcay Canpolat, Asena/0000-0003-1186-2960
FU Scientific and Technological Research Council of Turkey [SBAG216S979]
FX This work was supported by Grants (No. SBAG216S979) from The Scientific
   and Technological Research Council of Turkey
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NR 78
TC 14
Z9 15
U1 0
U2 14
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0305-1870
EI 1440-1681
J9 CLIN EXP PHARMACOL P
JI Clin. Exp. Pharmacol. Physiol.
PD JAN
PY 2022
VL 49
IS 1
BP 46
EP 59
DI 10.1111/1440-1681.13590
EA OCT 2021
PG 14
WC Pharmacology & Pharmacy; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Physiology
GA XL5YI
UT WOS:000711735900001
PM 34519087
DA 2025-06-11
ER

PT J
AU Gelaleti, RB
   Damasceno, DC
   Lima, PHO
   Salvadori, DMF
   Calderon, IDP
   Peraçoli, JC
   Rudge, MVC
AF Gelaleti, Rafael Bottaro
   Damasceno, Debora Cristina
   Ortiz Lima, Paula Helena
   Favero Salvadori, Daisy Maria
   Paranhos Calderon, Iracema de Mattos
   Peracoli, Jose Carlos
   Cunha Rudge, Marilza Vieira
TI Oxidative DNA damage in diabetic and mild gestational hyperglycemic
   pregnant women
SO DIABETOLOGY & METABOLIC SYNDROME
LA English
DT Article
DE Diabetes; Pregnancy; Mild gestational hyperglycemia; Genotoxicity;
   Oxidative DNA damage
ID METABOLIC SYNDROME; MELLITUS; LEUKOCYTES; ASSOCIATION; PREVALENCE;
   LEVEL; CELLS; RISK
AB Background: Pregnant women with mild gestational hyperglycemia present high risk for hypertension, obesity and hyperglycemia, and appeared to reproduce the model of metabolic syndrome in pregnancy, with hyperinsulinemia and insulin resistance. Our clinical studies showed that mild gestational hyperglycemia or gestational diabetes are related to similar adverse maternal and perinatal outcomes. Hyperglycemia and other factors associated with diabetes generate reactive oxygen species that increase DNA damage levels. The aim of this study was to evaluate oxidative DNA damage in lymphocytes of pregnant women with diabetes or mild gestational hyperglycemia.
   Methods: The study included 111 pregnant women distributed into three groups based on oral glucose tolerance test (OGTT) and glycemic profiles (GP), as follows: Normal OGTT and GP (control group); Normal OGTT and abnormal GP (mild gestational hyperglycemia group); Abnormal OGTT and GP (diabetic group). Maternal blood samples (5-10 mL) were collected and processed for determination of oxidative DNA damage by the comet assay, using Fpg and Endo III enzymes. Urine samples were also collected for determination of 8-OHdG concentrations by ELISA.
   Results: Subjects in the diabetes group presented increased amount of oxidized purines, while mild gestational hyperglycemia women presented with increased oxidized pyrimidines, compared to the control group.
   Conclusion: Gestational, overt diabetes and mild gestational hyperglycemia, were all related to increased oxidative DNA damage. Diabetic pregnant women showed increased level of oxidative DNA damage, perhaps mainly due to hyperglycemia. On the other hand, oxidative DNA damage detected in women with mild gestational hyperglycemia might be associated with repercussions from obesity, hypertension and/or insulin resistance. Interestingly, the type of DNA base affected seemed to be dependent on the glycemic profile or oxidative stress.
C1 [Gelaleti, Rafael Bottaro; Damasceno, Debora Cristina; Favero Salvadori, Daisy Maria; Paranhos Calderon, Iracema de Mattos; Peracoli, Jose Carlos; Cunha Rudge, Marilza Vieira] UNESP Univ Estadual Paulista, Botucatu Med Sch, Sao Paulo, Brazil.
   [Ortiz Lima, Paula Helena] Inst Dante Pazzanese Cardiol, Sao Paulo, Brazil.
   [Cunha Rudge, Marilza Vieira] Univ Estadual Paulista, Fac Med Botucatu, Dept Ginecol & Obstet, BR-18618000 Sao Paulo, Brazil.
C3 Universidade Estadual Paulista; Instituto Dante Pazzanese de
   Cardiologia; Universidade Estadual Paulista
RP Rudge, MVC (corresponding author), UNESP Univ Estadual Paulista, Botucatu Med Sch, Sao Paulo, Brazil.
EM marilzarudge@gmail.com
RI Rudge, Marilza/S-9057-2018; Lima, Paula/H-3559-2015; Calderon,
   Iracema/W-4336-2019; Peracoli, Jose Carlos/GME-1756-2022; Vieira Cunha
   Rudge, Marilza/C-8338-2012; Damasceno, Debora Cristina/C-7234-2012;
   Gelaleti, Rafael/F-5664-2012; Peracoli, Jose Carlos/G-4923-2012;
   Calderon, Iracema/C-8136-2012; FAVERO SALVADORI, DAISY MARIA/E-7744-2012
OI Vieira Cunha Rudge, Marilza/0000-0002-9227-832X; Damasceno, Debora
   Cristina/0000-0002-7003-9643; Gelaleti, Rafael/0000-0002-6098-9899;
   Peracoli, Jose Carlos/0000-0002-3273-3001; Calderon,
   Iracema/0000-0003-4761-4336; FAVERO SALVADORI, DAISY
   MARIA/0000-0001-9323-3134; Ortiz Lima, Paula Helena/0000-0002-0631-8074
FU FAPESP - Fundacao de Amparo a Pesquisa do Estado de Sao Paulo/Brazil
   [2008/06642-6]; Swedish Research Council [2008-06642] Funding Source:
   Swedish Research Council
FX The authors are thankful to the staff of the Laboratory for Experimental
   Research in Gynecology and Obstetrics and to Talisia Moretto for their
   technical contribution, and to the Research Support Center (GAP) of
   Botucatu Medical School - Unesp for assisting with statistical analyses.
   We thank Dr. Steven S. Witkin (Cornell University) for contributions to
   the final draft of the manuscript and for English language
   recommendations. This study was supported by FAPESP - Fundacao de Amparo
   a Pesquisa do Estado de Sao Paulo/Brazil (Grant number 2008/06642-6).
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NR 33
TC 26
Z9 28
U1 0
U2 8
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1758-5996
J9 DIABETOL METAB SYNDR
JI Diabetol. Metab. Syndr.
PD JAN 15
PY 2015
VL 7
AR 1
DI 10.1186/1758-5996-7-1
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA CB2RT
UT WOS:000349476400001
PM 25810781
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Grassi, G
   Bertoli, S
   Seravalle, G
AF Grassi, Guido
   Bertoli, Silvio
   Seravalle, Gino
TI Sympathetic nervous system: role in hypertension and in chronic kidney
   disease
SO CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION
LA English
DT Review
DE carotid baroreceptor stimulation; hypertension; renal denervation; renal
   failure; sympathetic nervous system
ID STAGE RENAL-DISEASE; BLOOD-PRESSURE; RESISTANT HYPERTENSION;
   NITRIC-OXIDE; NEUROGENIC HYPERTENSION; AUTONOMIC ACTIVITY;
   STRESS-RESPONSE; ANGIOTENSIN-II; L-NAME; DENERVATION
AB Purpose of review
   A number of cardiovascular disease have been shown to be characterized by a marked increase in sympathetic drive to the heart and peripheral circulation. This is the case for essential hypertension, congestive heart failure, obesity, metabolic syndrome and chronic renal failure. This review focuses on the most recent findings documenting the role of sympathetic neural factors in the development and progression of the hypertensive state as well as of target organ damage. It also reviews the participation of sympathetic neural factors in the development of the earlier stages of renal failure.
   Recent findings
   A marked increase in sympathetic neural discharge, as assessed via the microneurographic technique, has been shown to occur in the predialytic stage of chronic renal failure. Recent evidence, however, indicates that also in the earlier clinical phases of kidney disease, sympathetic activation is detectable. Further data show that sympathetic neural mechanisms participate in renal and/or hypertensive disease progression, favouring the development of target organ damage. Finally, recent findings indicate that the metabolic disarray frequently complicating the high blood pressure state (metabolic syndrome, dislipidemia, insulin resistance) may have as pathophysiological background a sympathetic overdrive. Altogether these data represent the rationale for employing in hypertension (and particularly in resistant hypertension) therapeutic interventions such as carotid baroreceptor stimulation and renal denervation, capable of exerting sympathoinhibitory effects.
   Summary
   The sympathetic nervous system represents a major pathophysiological hallmark of both hypertension and renal failure and is an important target for the therapeutic intervention.
C1 [Grassi, Guido] Univ Milano Bicocca, Osped San Gerardo, Dipartimento Med Clin Prevenz & Biotecnol Sanit, Med Clin, Milan, Italy.
   [Bertoli, Silvio] IRCCS Multimed, Unita Operat Nefrol & Dialisi, Milan, Italy.
   [Seravalle, Gino] Ist Auxol Italiano, Milan, Italy.
C3 San Gerardo Hospital; University of Milano-Bicocca; IRCCS Multimedica;
   IRCCS Istituto Auxologico Italiano
RP Grassi, G (corresponding author), Osped S Gerardo dei Tintori, Med Clin, Via Pergolesi 33, I-20052 Milan, Italy.
EM guido.grassi@unimib.it
RI seravalle, gino/K-1442-2019
OI seravalle, gino/0000-0003-3638-8011
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NR 52
TC 93
Z9 100
U1 0
U2 16
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1062-4821
J9 CURR OPIN NEPHROL HY
JI Curr. Opin. Nephrol. Hypertens.
PD JAN
PY 2012
VL 21
IS 1
BP 46
EP 51
DI 10.1097/MNH.0b013e32834db45d
PG 6
WC Urology & Nephrology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology; Cardiovascular System & Cardiology
GA 863DZ
UT WOS:000298144300007
PM 22080859
DA 2025-06-11
ER

PT J
AU Mugabo, Y
   Mukaneza, Y
   Renier, G
AF Mugabo, Yves
   Mukaneza, Yvette
   Renier, Genevieve
TI Palmitate induces C-reactive protein expression in human aortic
   endothelial cells. Relevance to fatty acid-induced endothelial
   dysfunction
SO METABOLISM-CLINICAL AND EXPERIMENTAL
LA English
DT Article
ID NF-KAPPA-B; NITRIC-OXIDE PRODUCTION; NAD(P)H OXIDASE;
   METABOLIC-SYNDROME; VASCULAR CELLS; NADPH OXIDASE; MUSCLE-CELLS;
   ACTIVATION; KINASE; SYNTHASE
AB Circulating levels of free fatty acids are commonly elevated in patients with the metabolic syndrome and exert, through activating proinflammatory pathways, harmful effects of the vascular endothelium. In this study, we examined the effect of palmitate (PA) on endothelial C-reactive protein (CRP) expression and the role of CRP in PA-induced nitric oxide (NO) inhibition. Palmitate increased, in a dose-dependent manner, CRP protein expression and production in human aortic endothelial cells (HAECs). Induction of CRP protein was mimicked by ceramide, whereas bromopalmitate and other common free fatty acids such as oleate or linoleate were ineffective. Palmitate also elicited reactive oxygen species production in HAECs, an effect prevented by protein kinase C (PKC) inhibition and adenosine monophosphate activated kinase (AMPK) activation. Palmitate-treated HAECs showed increased CRP messenger RNA expression and nuclear factor (NF)-kappa B activation. Induction of CRP expression by PA was prevented by antioxidants and normalized by PKC and mitogen-activated protein kinase inhibitors. Disrupting NF-kappa B and Janus kinase/signal transducers and activators of transcription pathways or inducing AMPK activation also suppressed the stimulatory effect of PA on CRP messenger RNA expression. Finally, in HAECs, PA reduced NO release, an effect reversed by anti-CRP antibody. These data demonstrate that PA-induced endothelial CRP expression involves PKC-driven oxidative stress, possibly through AMPK inhibition, and activation of downstream redox-sensitive signaling pathways, including NF-kappa B. They further support a role for endothelial cell derived CRP as mediator of the suppressive effect of PA on NO production. (C) 2011 Elsevier Inc. All rights reserved.
C1 [Mugabo, Yves; Mukaneza, Yvette; Renier, Genevieve] Univ Montreal, Notre Dame Hosp, Dept Med, Ctr Hosp Univ Montreal Res Ctr CRCHUM, Montreal, PQ H3C 3J7, Canada.
C3 Universite de Montreal
RP Renier, G (corresponding author), Univ Montreal, Notre Dame Hosp, Dept Med, Ctr Hosp Univ Montreal Res Ctr CRCHUM, Montreal, PQ H3C 3J7, Canada.
EM genevieve.renier@umontreal.ca
FU Diabete Quebec
FX This study was supported by a grant from Diabete Quebec. The authors
   thank Dr Marc Prentki for his helpful assistance.
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NR 45
TC 29
Z9 38
U1 0
U2 4
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0026-0495
J9 METABOLISM
JI Metab.-Clin. Exp.
PD MAY
PY 2011
VL 60
IS 5
BP 640
EP 648
DI 10.1016/j.metabol.2010.06.014
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 756GV
UT WOS:000290000600007
PM 20727556
DA 2025-06-11
ER

PT J
AU Rojo, M
   Pérez, H
   Millán, AL
   Pautasso, MC
   Duarte, A
   Abruzzese, GA
   Motta, AB
   Frechtel, GD
   Cerrone, GE
AF Rojo, Mailen
   Perez, Hernan
   Millan, Andrea Liliana
   Pautasso, Maria Constanza
   Duarte, Alejandra
   Abruzzese, Giselle Adriana
   Motta, Alicia Beatriz
   Frechtel, Gustavo Daniel
   Cerrone, Gloria Edith
TI Mitochondrial DNA oxidation and content in different metabolic
   phenotypes of women with polycystic ovary syndrome
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Article
DE obesity; oxidative damage; metabolic syndrome; polycystic ovary
   syndrome; mitochondrial DNA
ID OBESITY; HEALTHY; SHOWS
AB Introduction Polycystic Ovary Syndrome (PCOS) affects 5-20% of reproductive-aged women. Insulin resistance (IR) is common in PCOS with consequent elevated risks of metabolic disorders and cardiovascular mortality. PCOS and obesity are complex conditions associated with Metabolic Syndrome (MS), contributing to cardiovascular disease and type 2 diabetes mellitus (T2D). Obesity and PCOS exacerbate each other, with central obesity driving metabolic changes. Mitochondrial dysfunction, characterized by oxidative stress and reduced antioxidant capacity, plays a key role in PCOS pathology.Methods In our study, we investigated 81 women with PCOS, and 57 control women aged 16 to 46 years old. Relative mitochondrial DNA (mtDNA) content and its oxidation level (8-oxoguanine, 8-OxoG) were determined in peripheral blood leukocytes by the SYBR Green method real-time PCR.Results Our findings showed that patients with PCOS had decreased mtDNA content and increased oxidation damage. Stratifying these patients by metabolic profile, revealed a progressive decline in mtDNA content from the normal-weight control group to the MHO-PCOS and MUO-PCOS groups, suggesting that lower mtDNA content is linked to obesity and worse metabolic profile. However, mtDNA oxidation levels did not differ significantly among these groups. Additionally, the decline in mtDNA content and the increase in oxidation levels between controls and patients with PCOS lost significance when these relationships were adjusted for the HOMA index.Discussion This finding suggests that IR could be the main factor contributing to mitochondrial dysfunction in PCOS. Maintaining optimal mtDNA copies are crucial for mitochondrial and cell function, suggesting potential therapeutic targets for PCOS-associated metabolic disturbances.
C1 [Rojo, Mailen; Millan, Andrea Liliana; Cerrone, Gloria Edith] Univ Buenos Aires, Fac Farm & Bioquim, Dept Microbiol Inmunol Biotecnol & Genet, Buenos Aires, Argentina.
   [Rojo, Mailen; Perez, Hernan; Millan, Andrea Liliana; Pautasso, Maria Constanza; Duarte, Alejandra; Frechtel, Gustavo Daniel; Cerrone, Gloria Edith] Univ Buenos Aires, Natl Sci & Tech Res Council CONICET, Inst Inmunol Genet & Metab INIGEM, Buenos Aires, Argentina.
   [Perez, Hernan; Frechtel, Gustavo Daniel] Hosp Clin Jose San Martin, Serv Nutr, Buenos Aires, Argentina.
   [Duarte, Alejandra; Motta, Alicia Beatriz; Frechtel, Gustavo Daniel] Inst Univ Ciencias Salud, Fdn Hector Alejandro HA Barcelo, Buenos Aires, Argentina.
   [Abruzzese, Giselle Adriana; Motta, Alicia Beatriz] Univ Buenos Aires, Ctr Estudios Farmacol & Bot CEFYBO, Natl Sci & Tech Res Council CONICET, Lab Fisiopatol Ovarica, Buenos Aires, Argentina.
C3 University of Buenos Aires; University of Buenos Aires; Consejo Nacional
   de Investigaciones Cientificas y Tecnicas (CONICET); Centro Nacional
   Patagonico (CENPAT); University of Buenos Aires; University of Buenos
   Aires Hospital; Hospital de Clinicas Jose de San Martin; Centro Nacional
   Patagonico (CENPAT); University of Buenos Aires; Consejo Nacional de
   Investigaciones Cientificas y Tecnicas (CONICET)
RP Rojo, M; Cerrone, GE (corresponding author), Univ Buenos Aires, Fac Farm & Bioquim, Dept Microbiol Inmunol Biotecnol & Genet, Buenos Aires, Argentina.; Rojo, M; Cerrone, GE (corresponding author), Univ Buenos Aires, Natl Sci & Tech Res Council CONICET, Inst Inmunol Genet & Metab INIGEM, Buenos Aires, Argentina.
EM maailen.rojo@gmail.com; gcerrone@ffyb.uba.ar
RI Abruzzese, Giselle/AAA-9542-2020
FU Universidad de Buenos Aires10.13039/501100005363; University of Buenos
   Aires
FX The authors wish to thank the study participants. Also, we would like to
   acknowledge the University of Buenos Aires for the support granted.
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NR 31
TC 0
Z9 0
U1 0
U2 0
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD JAN 9
PY 2025
VL 15
AR 1501306
DI 10.3389/fendo.2024.1501306
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA T0A1V
UT WOS:001401732000001
PM 39850475
OA gold
DA 2025-06-11
ER

PT J
AU Bailey, CJ
AF Bailey, Clifford J.
TI Uric acid and the cardio-renal effects of SGLT2 inhibitors
SO DIABETES OBESITY & METABOLISM
LA English
DT Review
DE cardiac; gout; obesity; renal; sodium; glucose co-transporter-2 (SGLT2)
   inhibitor; type 2 diabetes; uric acid
ID CHRONIC KIDNEY-DISEASE; TYPE-2 DIABETES-MELLITUS; COTRANSPORTER 2
   INHIBITION; BLOOD-PRESSURE; CARDIOVASCULAR-DISEASE; HEART-FAILURE;
   ESSENTIAL-HYPERTENSION; CELL-PROLIFERATION; METABOLIC SYNDROME;
   OXIDATIVE STRESS
AB Sodium/glucose co-transporter-2 (SGLT2) inhibitors, which lower blood glucose by increasing renal glucose elimination, have been shown to reduce the risk of adverse cardiovascular (CV) and renal events in type 2 diabetes. This has been ascribed, in part, to haemodynamic changes, body weight reduction and several possible effects on myocardial, endothelial and tubulo-glomerular functions, as well as to reduced glucotoxicity. This review evaluates evidence that an effect of SGLT2 inhibitors to lower uric acid may also contribute to reduced cardio-renal risk. Chronically elevated circulating uric acid concentrations are associated with increased risk of hypertension, CV disease and chronic kidney disease (CKD). The extent to which uric acid contributes to these conditions, either as a cause or an aggravating factor, remains unclear, but interventions that reduce urate production or increase urate excretion in hyperuricaemic patients have consistently improved cardio-renal prognoses. Uric acid concentrations are often elevated in type 2 diabetes, contributing to the "metabolic syndrome" of CV risk. Treating type 2 diabetes with an SGLT2 inhibitor increases uric acid excretion, reduces circulating uric acid and improves parameters of CV and renal function. This raises the possibility that the lowering of uric acid by SGLT2 inhibition may assist in reducing adverse CV events and slowing progression of CKD in type 2 diabetes. SGLT2 inhibition might also be useful in the treatment of gout and gouty arthritis, especially when co-existent with diabetes.
C1 [Bailey, Clifford J.] Aston Univ, Sch Life & Hlth Sci, Birmingham B4 7ET, W Midlands, England.
C3 Aston University
RP Bailey, CJ (corresponding author), Aston Univ, Sch Life & Hlth Sci, Birmingham B4 7ET, W Midlands, England.
EM c.j.bailey@aston.ac.uk
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NR 129
TC 137
Z9 147
U1 1
U2 25
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1462-8902
EI 1463-1326
J9 DIABETES OBES METAB
JI Diabetes Obes. Metab.
PD JUN
PY 2019
VL 21
IS 6
BP 1291
EP 1298
DI 10.1111/dom.13670
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA HX5CD
UT WOS:000467417200002
PM 30762288
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Infante, M
   Armani, A
   Mammi, C
   Fabbri, A
   Caprio, M
AF Infante, Marco
   Armani, Andrea
   Mammi, Caterina
   Fabbri, Andrea
   Caprio, Massimiliano
TI Impact of Adrenal Steroids on Regulation of Adipose Tissue
SO COMPREHENSIVE PHYSIOLOGY
LA English
DT Article
ID 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1; RENIN-ANGIOTENSIN SYSTEM;
   DIET-INDUCED OBESITY; ACTIVATED-RECEPTOR-GAMMA; ALDOSTERONE SYNTHASE
   INHIBITION; ADIPOCYTE PRECURSOR CELLS; CHRONIC HEART-FAILURE;
   HIGH-FAT-DIET; MINERALOCORTICOID RECEPTOR; METABOLIC SYNDROME
AB Corticosteroids are secreted by the adrenal glands and control the functions of adipose tissue via the activation of mineralocorticoid receptor (MR) and glucocorticoid receptor (GR). In turn, adipocytes release a large variety of adipokines into the bloodstream, regulating the function of several organs and tissues, including the adrenal glands, hereby controlling corticosteroid production. In adipose tissue, the activation of the MR by glucocorticoids (GC) and aldosterone affects important processes such as adipocyte differentiation, oxidative stress, autophagic flux, adipokine expression as well as local production of GC through upregulation of the enzyme 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1). Notably, the proinflammatory responses induced by the MR are counteracted by activation of the GR, whose activity inhibits the expression of inflammatory adipokines. Both GR and MR are deeply involved in adipogenesis and adipose expansion; hence pharmacological blockade of these two receptors has proven effective against adipose tissue dysfunction in experimental models of obesity and metabolic syndrome (MetS), suggesting a potential use for MR and GR antagonists in these clinical settings. Importantly, obesity and Cushing's syndrome (CS) share metabolic similarities and are characterized by high levels of circulating corticosteroids, which in turn are able to deeply affect adipose tissue. In addition, pharmacological approaches aimed at reducing aldosterone and GC levels, by means of the inhibition of CYP11B2 (aldosterone synthase) or 11 beta-HSD1, represent alternative strategies to counter the detrimental effects of excessive levels of corticosteroids, which are often observed in obesity and, more general, in MetS. (C) 2017 American Physiological Society.
C1 [Infante, Marco; Fabbri, Andrea] Univ Tor Vergata, ASL Roma 2, CTO A Alesini Hosp, Unit Endocrinol & Metab Dis,Dept Syst Med, Rome, Italy.
   [Armani, Andrea; Mammi, Caterina; Caprio, Massimiliano] IRCCS San Raffaele Pisana, Lab Cardiovasc Endocrinol, Rome, Italy.
   [Caprio, Massimiliano] San Raffaele Roma Open Univ, Dept Human Sci & Promot Qual Life, Rome, Italy.
C3 University of Rome Tor Vergata; Ospedale Sandro Pertini; IRCCS San
   Raffaele Pisana
RP Caprio, M (corresponding author), IRCCS San Raffaele Pisana, Lab Cardiovasc Endocrinol, Rome, Italy.; Caprio, M (corresponding author), San Raffaele Roma Open Univ, Dept Human Sci & Promot Qual Life, Rome, Italy.
EM massimiliano.caprio@sanraffaele.it
RI Armani, Andrea/AAC-2071-2022; Mammi, Caterina/O-1047-2013; Infante, MD,
   PhD, FACN, Marco/B-8735-2019; Caprio, Massimiliano/J-3020-2012
OI Infante, MD, PhD, FACN, Marco/0000-0003-2032-8735; ARMANI,
   Andrea/0000-0002-2130-1596; mammi, caterina/0000-0002-2687-4422; Caprio,
   Massimiliano/0000-0003-0722-7163
FU Ministero della Salute [PE-2011-02347070]; MIUR [2015ZTT5KB]; COST
   Action ADMIRE [BM1301]
FX This work was supported, in part, by a grant from Ministero della Salute
   (BANDO 2011-2012 Progetti Collaborazione Ricercatori Italiani
   all'Estero; project grant PE-2011-02347070 to M. Caprio), and by a grant
   of MIUR (Progetti di Ricerca di interesse Nazionale 2015 project code
   2015ZTT5KB to M. Caprio, work package leader). The Authors wish to thank
   Jill Kitchen for English editing. The authors would like to acknowledge
   networking support by the COST Action ADMIRE BM1301. The authors declare
   no conflicts of interest. This paper is dedicated to the memory of our
   beloved Professor Aldo Isidori.
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NR 248
TC 36
Z9 36
U1 0
U2 10
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 2040-4603
J9 COMPR PHYSIOL
JI Compr. Physiol.
PD OCT
PY 2017
VL 7
IS 4
BP 1425
EP 1447
DI 10.1002/cphy.c160037
PG 23
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA FG8FV
UT WOS:000410665700011
PM 28915330
DA 2025-06-11
ER

PT J
AU Lee, Y
   Fluckey, JD
   Chakraborty, S
   Muthuchamy, M
AF Lee, Yang
   Fluckey, James D.
   Chakraborty, Sanjukta
   Muthuchamy, Mariappan
TI Hyperglycemia- and hyperinsulinemia-induced insulin resistance causes
   alterations in cellular bioenergetics and activation of inflammatory
   signaling in lymphatic muscle
SO FASEB JOURNAL
LA English
DT Article
DE metabolism; lymphatic contractility; insulin signaling; glycolysis;
   signal transduction
ID VASCULAR SMOOTH-MUSCLE; GLUCOSE-TRANSPORTER GLUT4; PERINUCLEAR STORAGE
   COMPARTMENT; OXIDATIVE STRESS; SKELETAL-MUSCLE; PROTEIN-KINASE;
   ADIPOSE-TISSUE; METABOLIC SYNDROME; MICE LACKING; RAT MODEL
AB Insulin resistance is a well-known risk factor for obesity, metabolic syndrome (MetSyn) and associated cardiovascular diseases, but its mechanisms are undefined in the lymphatics. Mesenteric lymphatic vessels from MetSyn or LPS-injected rats exhibited impaired intrinsic contractile activity and associated inflammatory changes. Hence, we hypothesized that insulin resistance in lymphatic muscle cells (LMCs) affects cell bioenergetics and signaling pathways that consequently alter contractility. LMCs were treated with different concentrations of insulin or glucose or both at various time points to determine insulin resistance. Onset of insulin resistance significantly impaired glucose uptake, mitochondrial function, oxygen consumption rates, glycolysis, lactic acid, and ATP production in LMCs. Hyperglycemia and hyperinsulinemia also impaired the PI3K/Akt while enhancing the ERK/p38MAPK/JNK pathways in LMCs. Increased NF-kappa B nuclear translocation and macrophage chemoattractant protein-1 and VCAM-1 levels in insulin-resistant LMCs indicated activation of inflammatory mechanisms. In addition, increased phosphorylation of myosin light chain-20, a key regulator of lymphatic muscle contraction, was observed in insulin-resistant LMCs. Therefore, our data elucidate the mechanisms of insulin resistance in LMCs and provide the first evidence that hyperglycemia and hyperinsulinemia promote insulin resistance and impair lymphatic contractile status by reducing glucose uptake, altering cellular metabolic pathways, and activating inflammatory signaling cascades.-Lee, Y., Fluckey, J.D., Chakraborty, S., Muthuchamy, M. Hyperglycemia- and hyperinsulinemia-induced insulin resistance causes alterations in cellular bioenergetics and activation of inflammatory signaling in lymphatic muscle.
C1 [Lee, Yang; Chakraborty, Sanjukta; Muthuchamy, Mariappan] Texas A&M Univ, Dept Med Physiol, College Stn, TX USA.
   [Fluckey, James D.] Texas A&M Univ, Dept Hlth & Kinesiol, College Stn, TX USA.
C3 Texas A&M University System; Texas A&M University College Station; Texas
   A&M University System; Texas A&M University College Station
RP Chakraborty, S; Muthuchamy, M (corresponding author), Texas A&M Hlth Sci Ctr, Coll Med, Dept Med Physiol, College Stn, TX 77843 USA.
EM schakraborty@medicine.tamhsc.edu; marim@tamu.edu
RI Chakraborty, Sanjukta/AFO-9240-2022
OI Fluckey, James/0000-0003-1231-0412; Chakraborty,
   Sanjukta/0000-0002-4869-3198; Lee, Yang/0000-0002-8004-338X
FU U.S. National Institutes of Health, National Institute of Diabetes and
   Digestive and Kidney Diseases [RO1 DK99221]; Department of Medical
   Physiology, Lymphatic Graduate Student Fellowship
FX The authors thank the Texas A&M Health Science Center Integrated
   Microscopy and Imaging Laboratory, Texas A&M Image Analysis Laboratory,
   and Texas A&M Qualitative Biology Facility Core for their technical
   support. This work was supported by U.S. National Institutes of Health,
   National Institute of Diabetes and Digestive and Kidney Diseases Grant
   RO1 DK99221 (to M.M.) and Department of Medical Physiology, Lymphatic
   Graduate Student Fellowship (to Y.L.). The authors declare no conflicts
   of interest.
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NR 89
TC 52
Z9 56
U1 0
U2 8
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0892-6638
EI 1530-6860
J9 FASEB J
JI Faseb J.
PD JUL
PY 2017
VL 31
IS 7
BP 2744
EP 2759
DI 10.1096/fj.201600887R
PG 16
WC Biochemistry & Molecular Biology; Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA FB1VF
UT WOS:000405931000004
PM 28298335
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Costache, II
   Miftode, E
   Mitu, O
   Aursulesei, V
AF Costache, Irina Iuliana
   Miftode, Egidia
   Mitu, Ovidiu
   Aursulesei, Viviana
TI Sex Differences in Cardiovascular Risk Factors in a Rural Community from
   North Romania Region
SO REVISTA DE CERCETARE SI INTERVENTIE SOCIALA
LA English
DT Article
DE cardiovascular disease; cardiovascular risk factors; coronary heart
   disease; stroke; metabolic syndrome
ID AMERICAN-HEART-ASSOCIATION; DISEASE PREVENTION; WOMEN; STATEMENT;
   HEALTH; MEN
AB The prevalence of coronary heart disease is higher in men but the prevalence of stroke and the annual number of cardiovascular deaths are higher in women. Despite these findings, the cardiovascular risk in the female population is still underestimated. The present study aimed to identify cardiovascular risk factors and correlations with atherosclerotic cardiovascular disease in 285 patients from a rural community in Romania, aged between 26-92 years, 187 (65,6%) females, 98 (34,4%) males, in order to establish gender differences. Traditional risk factors were assessed. We used descriptive statistic methods to calculate the average and standard deviation of the assessed parameters. Divided by gender, the cardiovascular risk factors presented important differences. Almost all cardiovascular risk factors were more importantly represented in the female group: type 2 diabetes mellitus (73.0%), chronic stress (70.0%), family history of cardiovascular disease (57.0%). Obesity was frequent in females but with no statistical difference. Of all the women, 57.9% had arterial hypertension compared to men (27.7%) the statistical significance being almost insignificant (p = 0.052). Women had 4.3 times greater odds of obesity, 14.2 fold increased odds for abdominal adiposity, 2.8 times greater odds of high waist-hip-ratio and more than three-fold greater odds of having metabolic syndrome (p = 0.001). Among men, BMI and waist circumference were significantly correlated with blood pressure, triglycerides, total, LDL-, and HDL-cholesterol and fasting glucose; in women, only blood pressure was positively associated with BMI and waist circumference. Further studies are needed to establish the correlation between gender and cardiovascular risk factors.
C1 [Costache, Irina Iuliana; Mitu, Ovidiu; Aursulesei, Viviana] Univ Med & Pharm Gr T Popa, Dept Internal Med Iasi, Iasi, Romania.
   [Miftode, Egidia] Univ Med & Pharm Gr T Popa, Dept Infect Dis, Iasi, Romania.
C3 Grigore T Popa University of Medicine & Pharmacy; Grigore T Popa
   University of Medicine & Pharmacy
RP Costache, II (corresponding author), Univ Med & Pharm Gr T Popa, Dept Internal Med Iasi, Iasi, Romania.
EM irinaiulianacostache@yahoo.com; emiftode@yahoo.co.uk;
   mituovidiu@yahoo.co.uk; aursuleseiv@yahoo.com
RI Miftode, Egidia/AAX-7894-2020; Mitu, Ovidiu/ABA-1011-2021; ONOFREI
   AURSULESEI, VIVIANA/AGY-3366-2022
OI ONOFREI AURSULESEI, VIVIANA/0000-0002-2762-0918
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NR 16
TC 10
Z9 10
U1 0
U2 6
PU EDITURA LUMEN, IASI
PI IASI
PA HOLT ROMANIA FCSSCF FILIALA, IASI STR BISTRITA, NR 7, BL B13, PARTER, AP
   3, IASI, 00000, ROMANIA
SN 1583-3410
EI 1584-5397
J9 REV CERCET INTERV SO
JI Rev. Cercet. Interv. Soc.
PD DEC
PY 2016
VL 55
BP 204
EP 214
PG 11
WC Social Sciences, Interdisciplinary
WE Social Science Citation Index (SSCI)
SC Social Sciences - Other Topics
GA EF9FU
UT WOS:000390636900013
DA 2025-06-11
ER

PT J
AU Capdor, J
   Foster, M
   Petocz, P
   Samman, S
AF Capdor, Jasmine
   Foster, Meika
   Petocz, Peter
   Samman, Samir
TI Zinc and glycemic control: A meta-analysis of randomised placebo
   controlled supplementation trials in humans
SO JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
LA English
DT Article
DE Zinc; Glucose; HbA1c; Insulin
ID DEPENDENT DIABETES-MELLITUS; AND/OR MINERAL SUPPLEMENTATION;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; OXIDATIVE STRESS; DEFICIENT
   RATS; PLASMA-GLUCOSE; DIETARY ZINC; SERUM ZINC; TYPE-2
AB Background: Impaired zinc metabolism is prominent in chronic disorders including cardiovascular disease and diabetes. Zinc has the potential to affect glucose homeostasis in animals and humans and hence impact the risk of type 2 diabetes mellitus.
   Methods: A systematic review and meta-analysis of randomised placebo controlled trials was conducted to determine the effect of zinc supplementation on fasting blood glucose, HbA1c, serum insulin and serum zinc concentrations. Relevant studies for inclusion were identified from a literature search of electronic databases up to July 2011.
   Results: Fourteen reports (n = 3978 subjects) were included in the meta-analysis. In the overall analysis, a small but statistically significant reduction in fasting glucose concentrations was observed (-0.19 +/- 0.08 mmol/L, P = 0.013) after zinc supplementation. HbA1c tended to decrease in zinc-supplemented individuals (-0.64 +/- 0.36%, P = 0.072). No significant effect was observed for serum insulin concentrations. Plasma zinc concentrations increased significantly following supplementation (+4.03 +/- 0.81 mu mol/L, P = 0.001). In secondary analyses of participants with chronic metabolic disease (types 1 and 2 diabetes mellitus, metabolic syndrome and obesity), zinc supplementation produced a greater reduction in glucose concentrations (-0.49 +/- 0.11 mmol/L, P = 0.001) compared to the effect that was observed in healthy participants.
   Conclusion: The significant albeit modest reduction in glucose concentrations and tendency for a decrease in HbA1c following zinc supplementation suggest that zinc may contribute to the management of hyperglycemia in individuals with chronic metabolic disease. (C) 2012 Elsevier GmbH. All rights reserved.
C1 [Capdor, Jasmine; Foster, Meika; Samman, Samir] Univ Sydney, Discipline Nutr & Metab, Sch Mol Biosci, Sydney, NSW 2006, Australia.
   [Petocz, Peter] Macquarie Univ, Dept Stat, N Ryde, NSW 2109, Australia.
C3 University of Sydney; Macquarie University
RP Samman, S (corresponding author), Univ Sydney, Discipline Nutr & Metab, Sch Mol Biosci, Bldg G08, Sydney, NSW 2006, Australia.
EM samir.samman@sydney.edu.au
OI Samman, Samir/0000-0001-6326-0481
CR Al-Maroof RA, 2006, SAUDI MED J, V27, P344
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NR 65
TC 130
Z9 136
U1 0
U2 23
PU ELSEVIER GMBH, URBAN & FISCHER VERLAG
PI JENA
PA OFFICE JENA, P O BOX 100537, 07705 JENA, GERMANY
SN 0946-672X
J9 J TRACE ELEM MED BIO
JI J. Trace Elem. Med. Biol.
PY 2013
VL 27
IS 2
BP 137
EP 142
DI 10.1016/j.jtemb.2012.08.001
PG 6
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 135WN
UT WOS:000318321500012
PM 23137858
DA 2025-06-11
ER

PT J
AU Agouni, A
   Ducluzeau, PH
   Benameur, T
   Faure, S
   Sladkova, M
   Duluc, L
   Leftheriotis, G
   Pechanova, O
   Delibegovic, M
   Martinez, MC
   Andriantsitohaina, R
AF Agouni, Abdelali
   Ducluzeau, Pierre-Henri
   Benameur, Tarek
   Faure, Sebastien
   Sladkova, Martina
   Duluc, Lucie
   Leftheriotis, Georges
   Pechanova, Olga
   Delibegovic, Mirela
   Martinez, Maria Carmen
   Andriantsitohaina, Ramaroson
TI Microparticles from Patients with Metabolic Syndrome Induce Vascular
   Hypo-Reactivity via Fas/Fas-Ligand Pathway in Mice
SO PLOS ONE
LA English
DT Article
ID SMOOTH-MUSCLE-CELLS; SHED MEMBRANE MICROPARTICLES; NITRIC-OXIDE;
   CIRCULATING MICROPARTICLES; ENDOTHELIAL MICROPARTICLES; UP-REGULATION;
   FAS; EXPRESSION; DEATH; HYPOREACTIVITY
AB Microparticles are membrane vesicles with pro-inflammatory properties. Circulating levels of microparticles have previously been found to be elevated in patients with metabolic syndrome (MetS). The present study aimed to evaluate the effects of in vivo treatment with microparticles, from patients with MetS and from healthy subjects (HS), on ex vivo vascular function in mice. Microparticles isolated from MetS patients or HS, or a vehicle were intravenously injected into mice, following which vascular reactivity in response to vasoconstrictor agonists was assessed by myography with respect to cyclo-oxygenase pathway, oxidative and nitrosative stress. Injection of microparticles from MetS patients into mice induced vascular hyporeactivity in response to serotonin. Hypo-reactivity was associated with up-regulation of inducible NO-synthase and increased production of NO, and was reversed by the NO-synthase inhibitor (N-G-nitro-L-arginine). The selective COX-2 inhibitor (NS398) reduced the contractile effect of serotonin in aortas from mice treated with vehicle or HS microparticles; however, this was not observed within mice treated with MetS microparticles, probably due to the ability of MetS microparticles to enhance prostacyclin. MetS microparticle-mediated vascular dysfunction was associated with increased reactive oxygen species (ROS) and enhanced expression of the NADPH oxidase subunits. Neutralization of the proinflammatory pathway Fas/FasL completely prevented vascular hypo-reactivity and the ability of MetS microparticles to enhance both inducible NO-synthase and monocyte chemoattractant protein-1 (MCP-1). Our data provide evidence that microparticles from MetS patients induce ex vivo vascular dysfunction by increasing both ROS and NO release and by altering cyclo-oxygenase metabolites and MCP-1 through the Fas/FasL pathway.
C1 [Agouni, Abdelali; Ducluzeau, Pierre-Henri; Benameur, Tarek; Faure, Sebastien; Sladkova, Martina; Duluc, Lucie; Martinez, Maria Carmen; Andriantsitohaina, Ramaroson] INSERM, U694, Angers, France.
   [Agouni, Abdelali; Ducluzeau, Pierre-Henri; Benameur, Tarek; Faure, Sebastien; Sladkova, Martina; Duluc, Lucie; Martinez, Maria Carmen; Andriantsitohaina, Ramaroson] Univ Angers, Angers, France.
   [Agouni, Abdelali; Delibegovic, Mirela] Univ Aberdeen, Inst Biol & Environm Sci, Aberdeen, Scotland.
   [Ducluzeau, Pierre-Henri] CHU Angers, Dept Endocrinol & Diabet, Angers, France.
   [Sladkova, Martina] Slovak Acad Sci, Inst Normal & Pathol Physiol, Bratislava, Slovakia.
   [Leftheriotis, Georges; Pechanova, Olga] INSERM, U771, Angers, France.
C3 Universite d'Angers; Institut National de la Sante et de la Recherche
   Medicale (Inserm); Universite d'Angers; University of Aberdeen;
   Universite d'Angers; Centre Hospitalier Universitaire d'Angers; Slovak
   Academy of Sciences; Institute of Normal & Pathological Physiology, SAS;
   Universite d'Angers; Institut National de la Sante et de la Recherche
   Medicale (Inserm)
RP Agouni, A (corresponding author), INSERM, U694, Angers, France.
EM ramaroson.andriantsitohaina@univ-angers.fr
RI ANDRIANTSITOHAINA, Ramaroson/H-5286-2018; Sladkova-Faure,
   Martina/AAD-1505-2019; Martinez, Maria Carmen/LSJ-1622-2024; Agouni,
   Abdelali/AAP-5298-2020; BENAMEUR, T/KIH-8629-2024; ducluzeau,
   pierre-henri/ABE-1092-2021; Pechanova, Olga/V-9959-2018
OI Faure, Sebastien/0000-0001-7524-8295; Agouni,
   Abdelali/0000-0002-8363-1582; andriantsitohaina,
   ramaroson/0000-0002-4770-3585; Pechanova, Olga/0000-0001-5476-2949;
   Duluc, Lucie/0000-0002-5952-8008; Delibegovic,
   Mirela/0000-0001-6193-3152; Sladkova-Faure, Martina/0000-0003-4548-0290
FU Fonds Europeen pour le Developpement Regional [8891]; Fondation pour la
   Recherche Medicale [INE20050303433, INE20060306500]; CNRS; INSERM;
   Universite d'Angers; French Education Ministry (MENRT)
FX This work was supported in part by grants from Fonds Europeen pour le
   Developpement Regional (R.A. n degrees 8891), Fondation pour la
   Recherche Medicale (R.A. n degrees INE20050303433 and MCM n degrees
   INE20060306500), CNRS, INSERM and Universite d'Angers. A.A. and T.B. are
   recipients of doctoral fellowships from the French Education Ministry
   (MENRT). R.A. is supported by a "Contrat d'Interface" INSERM. The
   funders had no role in study design, data collection and analysis,
   decision to publish, or preparation of the manuscript.
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NR 42
TC 50
Z9 53
U1 0
U2 6
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD NOV 15
PY 2011
VL 6
IS 11
AR e27809
DI 10.1371/journal.pone.0027809
PG 11
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 855HU
UT WOS:000297555300053
PM 22110764
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Ko, GTC
   Chan, JCN
AF Ko, G. T. C.
   Chan, J. C. N.
TI Burden of obesity - lessons learnt from Hong Kong Chinese
SO OBESITY REVIEWS
LA English
DT Article; Proceedings Paper
CT 7th Conference on Obesity-Related Chronic Disease Control in China
CY NOV 21-23, 2006
CL Beijing, PEOPLES R CHINA
SP Int Life Sci Inst Focal Point China
DE disease burden; Hong Kong; obesity
ID BODY-MASS INDEX; CARDIOVASCULAR RISK-FACTORS; IMPAIRED
   GLUCOSE-TOLERANCE; WAIST-HIP RATIO; METABOLIC SYNDROME;
   PHYSICAL-ACTIVITY; CIRCUMFERENCE; HEALTH; PREVALENCE; OVERWEIGHT
AB There is now a pandemic of chronic diseases in Asian countries, driven mainly by obesity, diabetes and cardio-renal complications. In Hong Kong, the reported prevalence of obesity, defined as body mass index (BMI) >= 25 kg m(-2), varied from one-quarter to one-third of the population. In a population-based survey conducted in 1995, 16.7% of Hong Kong adults had the metabolic syndrome (MES) (National Cholesterol Education Programme criterion). Obesity is now a global concern not only in adults but also among children and adolescents. In 2003, a territory-wide survey in Hong Kong reported the prevalence of central obesity and MES to be 9.0% and 2.4%, respectively, in Chinese adolescents. Overweight, positive family history of diabetes and studying at schools of lower academic grading were independent risk factors for the adolescent MES. Lifestyle modification with proper diet and exercise is essential for health protection. In accord with western data, a weight management programme in Hong Kong Chinese with a 4-6% reduction in body weight or waist circumference was associated with significant reductions in all cardiovascular risk factors. Psychosocial factors related to chronic diseases are also of growing concern. In Hong Kong Chinese, increasing BMI was associated with a lower number of sleeping hours and increasing working hours, suggesting an intimate relationship between physical health and psychosocial stress. Chronic non-communicable diseases are therefore major health threats in Hong Kong, with obesity as one of the major risk factors. A multidimensional and multidisciplinary health promotion and disease management plan is urgently needed to control these epidemics.
C1 [Chan, J. C. N.] Chinese Univ Hong Kong, Prince Wales Hosp Shatin, Dept Med & Therapeut, Hong Kong, Hong Kong, Peoples R China.
   [Ko, G. T. C.] Chinese Univ Hong Kong, Prince Wales Hosp Shatin, Hong Kong Inst Diabet & Obes, Hong Kong, Hong Kong, Peoples R China.
C3 Chinese University of Hong Kong; Chinese University of Hong Kong
RP Chan, JCN (corresponding author), Chinese Univ Hong Kong, Prince Wales Hosp Shatin, Dept Med & Therapeut, Hong Kong, Hong Kong, Peoples R China.
EM jchan@cuhk.edu.hk
RI Chan, Juliana/B-7918-2016
OI Chan, Juliana/0000-0003-1325-1194
CR [Anonymous], Preventing chronic diseases: A vital investment
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NR 42
TC 19
Z9 25
U1 1
U2 19
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1467-7881
EI 1467-789X
J9 OBES REV
JI Obes. Rev.
PD MAR
PY 2008
VL 9
SU 1
BP 35
EP 40
DI 10.1111/j.1467-789X.2007.00436.x
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Endocrinology & Metabolism
GA 269MQ
UT WOS:000253653500008
PM 18307697
OA Bronze
DA 2025-06-11
ER

PT J
AU Tsimihodimos, V
   Psoma, O
AF Tsimihodimos, Vasilis
   Psoma, Ourania
TI Extra Virgin Olive Oil and Metabolic Diseases
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE extra virgin olive oil; metabolic diseases; Mediterranean diet; diabetes
   mellitus; lipid disorders; blood pressure; obesity; cardiovascular
   disease
ID POSTPRANDIAL OXIDATIVE STRESS; IMPROVE ENDOTHELIAL FUNCTION;
   MEDITERRANEAN DIET; BLOOD-PRESSURE; PHENOLIC-COMPOUNDS; LIPID PROFILE;
   FAT-DIET; CARDIOVASCULAR RISK; ALPHA-GLUCOSIDASE; NITRIC-OXIDE
AB Over the last few decades, metabolic syndrome coexisting with cardiovascular disease has evolved into a pandemic, making the need for more food-oriented therapeutic approaches and a redefinition of lifestyle imperative, with the Mediterranean diet being the linchpin of this effort. Extra virgin olive oil (EVOO), the key pillar of the Mediterranean diet and one of the most notorious edible oils worldwide, owes its popularity not only to its characteristic aromas and taste but mainly to a series of beneficial health attributes including anti-diabetic, hypolipidemic, anti-hypertensive and anti-obesity actions. In this narrative review, we aimed to illustrate and enlighten EVOO's metabolic properties through a pathogenetic approach, investigating its potential role in metabolic and cardiovascular health.
C1 [Tsimihodimos, Vasilis; Psoma, Ourania] Univ Ioannina, Sch Med, Dept Internal Med, Ioannina 45110, Greece.
C3 University of Ioannina
RP Tsimihodimos, V (corresponding author), Univ Ioannina, Sch Med, Dept Internal Med, Ioannina 45110, Greece.
EM vtsimi@uoi.gr; raniapsoma@gmail.com
RI Tsimihodimos, Vasilis/AAN-9888-2021
OI Tsimihodimos, Vasilis/0000-0003-1708-3415
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NR 110
TC 3
Z9 3
U1 2
U2 14
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD AUG
PY 2024
VL 25
IS 15
AR 8117
DI 10.3390/ijms25158117
PG 15
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA C1S3L
UT WOS:001287223900001
PM 39125686
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Mancilla, VJ
   Peeri, NC
   Silzer, T
   Basha, R
   Felini, M
   Jones, HP
   Phillips, N
   Tao, MH
   Thyagarajan, S
   Vishwanatha, JK
AF Mancilla, Viviana J.
   Peeri, Noah C.
   Silzer, Talisa
   Basha, Riyaz
   Felini, Martha
   Jones, Harlan P.
   Phillips, Nicole
   Tao, Meng-Hua
   Thyagarajan, Srikantha
   Vishwanatha, Jamboor K.
TI Understanding the Interplay Between Health Disparities and Epigenomics
SO FRONTIERS IN GENETICS
LA English
DT Review
DE epigenetics; cancer; health disparities; chronic disease; social
   determinants of health
ID METABOLIC SYNDROME; SOCIAL DETERMINANTS; ALZHEIMERS-DISEASE; RACIAL
   DISPARITIES; CANCER EPIGENETICS; OXIDATIVE STRESS; DNA METHYLATION;
   SEX-DIFFERENCES; RISK-FACTORS; ASTHMA
AB Social epigenomics has emerged as an integrative field of research focused on identification of socio-environmental factors, their influence on human biology through epigenomic modifications, and how they contribute to current health disparities. Several health disparities studies have been published using genetic-based approaches; however, increasing accessibility and affordability of molecular technologies have allowed for an in-depth investigation of the influence of external factors on epigenetic modifications (e.g., DNA methylation, micro-RNA expression). Currently, research is focused on epigenetic changes in response to environment, as well as targeted epigenetic therapies and environmental/social strategies for potentially minimizing certain health disparities. Here, we will review recent findings in this field pertaining to conditions and diseases over life span encompassing prenatal to adult stages.
C1 [Mancilla, Viviana J.; Silzer, Talisa; Jones, Harlan P.; Phillips, Nicole; Thyagarajan, Srikantha; Vishwanatha, Jamboor K.] Univ North Texas, Hlth Sci Ctr, Grad Sch Biomed Sci, Dept Microbiol Immunol & Genet, Ft Worth, TX 76107 USA.
   [Peeri, Noah C.; Tao, Meng-Hua] Univ North Texas, Hlth Sci Ctr, Dept Biostat & Epidemiol, Sch Publ Hlth, Ft Worth, TX USA.
   [Basha, Riyaz; Felini, Martha] Univ North Texas, Hlth Sci Ctr, Texas Coll Osteopath Med, Dept Pediat, Ft Worth, TX USA.
   [Basha, Riyaz; Felini, Martha; Jones, Harlan P.; Phillips, Nicole; Tao, Meng-Hua; Thyagarajan, Srikantha; Vishwanatha, Jamboor K.] Univ North Texas, Hlth Sci Ctr, Texas Ctr Hlth Dispar, Ft Worth, TX 76107 USA.
C3 University of North Texas System; University of North Texas Denton;
   University of North Texas System; University of North Texas Denton;
   University of North Texas System; University of North Texas Denton;
   University of North Texas System; University of North Texas Denton
RP Vishwanatha, JK (corresponding author), Univ North Texas, Hlth Sci Ctr, Grad Sch Biomed Sci, Dept Microbiol Immunol & Genet, Ft Worth, TX 76107 USA.; Vishwanatha, JK (corresponding author), Univ North Texas, Hlth Sci Ctr, Texas Ctr Hlth Dispar, Ft Worth, TX 76107 USA.
EM Jamboor.Vishwanatha@unthsc.edu
RI Jones, Harlan/ABC-9920-2020
OI Peeri, Noah/0000-0003-4278-650X
FU National Institute on Minority Health and Health Disparities of the
   National Institutes of Health [U54MD006882, S21MD012472]
FX This research reported in this publication was supported by the National
   Institute on Minority Health and Health Disparities of the National
   Institutes of Health under Award Numbers U54MD006882 and S21MD012472.
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NR 126
TC 35
Z9 38
U1 0
U2 12
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1664-8021
J9 FRONT GENET
JI Front. Genet.
PD AUG 20
PY 2020
VL 11
AR 903
DI 10.3389/fgene.2020.00903
PG 14
WC Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Genetics & Heredity
GA NJ6VN
UT WOS:000566182300001
PM 32973872
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Ma, LQ
   Zhang, JC
   Liu, Y
AF Ma, Linqin
   Zhang, Jingchun
   Liu, Yue
TI Roles and Mechanisms of Obstructive Sleep Apnea-Hypopnea Syndrome and
   Chronic Intermittent Hypoxia in Atherosclerosis: Evidence and
   Prospective
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Review
ID NF-KAPPA-B; POSITIVE AIRWAY PRESSURE; CARDIOVASCULAR-DISEASE;
   OBESE-PATIENTS; ENDOTHELIAL DYSFUNCTION; VASCULAR INFLAMMATION;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; GENE-EXPRESSION; HYPERTENSION
AB The morbidity and mortality of obstructive sleep apnea-hypopnea syndrome (OSAHS) are regarded as consequences of its adverse effects on the cardiovascular system. Chronic intermittent hypoxia (CIH) induced by OSAHS can result in vascular endothelial injury, thus promoting development of atherosclerosis (AS). Studies have shown that CIH is an independent risk factor for the occurrence and development of AS, but the underlying mechanism remains unclear. Here, we review clinical and fundamental studies reported during the last 10 years on the occurrence and development of AS mediated by CIH, focusing on inflammation, oxidative stress, insulin resistance, cell apoptosis, vascular endothelial injury, platelet activation, and neuroendocrine disorders. This review will offer current evidence and perspective to researchers for the development of effective intervention strategies for OSAHS-related cardiocerebrovascular diseases.
C1 [Ma, Linqin; Liu, Yue] China Acad Chinese Med Sci, Xiyuan Hosp, Cardiovasc Dis Ctr, Beijing 100091, Peoples R China.
   [Zhang, Jingchun] China Acad Chinese Med Sci, China Heart Inst Chinese Med, Beijing 100091, Peoples R China.
C3 Xiyuan Hospital, CACMS; China Academy of Chinese Medical Sciences; China
   Academy of Chinese Medical Sciences
RP Liu, Y (corresponding author), China Acad Chinese Med Sci, Xiyuan Hosp, Cardiovasc Dis Ctr, Beijing 100091, Peoples R China.; Zhang, JC (corresponding author), China Acad Chinese Med Sci, China Heart Inst Chinese Med, Beijing 100091, Peoples R China.
EM zhangjingchun276@vip.sohu.com; liuyueheart@hotmail.com
RI LIU, YUE/U-8022-2017
OI LIU, YUE/0000-0002-0084-863X
FU National Natural Science Foundation of China [81403266, 81373825,
   81573817]
FX This work was supported by National Natural Science Foundation of China
   (nos. 81403266, 81373825, and 81573817).
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NR 79
TC 42
Z9 50
U1 1
U2 25
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PY 2016
VL 2016
AR 8215082
DI 10.1155/2016/8215082
PG 10
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA DO6SO
UT WOS:000377913900001
PM 27293515
OA hybrid, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Varela, L
   Vázquez, MJ
   Cordido, F
   Nogueiras, R
   Vidal-Puig, A
   Diéguez, C
   López, M
AF Varela, Luis
   Vazquez, Maria J.
   Cordido, Fernando
   Nogueiras, Ruben
   Vidal-Puig, Antonio
   Dieguez, Carlos
   Lopez, Miguel
TI Ghrelin and lipid metabolism: key partners in energy balance
SO JOURNAL OF MOLECULAR ENDOCRINOLOGY
LA English
DT Review
ID ACTIVATED PROTEIN-KINASE; AGOUTI-RELATED PROTEIN; GROWTH-HORMONE
   SECRETAGOGUE; ENDOPLASMIC-RETICULUM STRESS; MELANIN-CONCENTRATING
   HORMONE; HYPOTHALAMIC NEUROPEPTIDE-Y; MESSENGER-RNA EXPRESSION;
   FATTY-ACID-METABOLISM; AMPHETAMINE-RELATED TRANSCRIPT; INSULIN-INDUCED
   HYPOGLYCEMIA
AB Ghrelin, the endogenous ligand of the GH secretagogue receptor, has a pleiotropic role in the modulation of energy balance. Recent evidence has demonstrated that besides its orexigenic role, ghrelin regulates central and peripheral lipid metabolism through specific control of hypothalamic AMP-activated protein kinase (AMPK), a critical metabolic gauge regulating both cellular and whole-body energy homeostasis. In this review, we summarize the new milestones of ghrelin's actions on energy balance, with particular focus on its molecular interaction with hypothalamic AMPK and fatty acid metabolism. Understanding this new metabolic pathway can provide new therapeutic targets for the treatment of obesity and the metabolic syndrome. Journal of Molecular Endocrinology (2011) 46, R43-R63
C1 [Varela, Luis; Vazquez, Maria J.; Nogueiras, Ruben; Dieguez, Carlos; Lopez, Miguel] Univ Santiago de Compostela, Dept Physiol, Sch Med, Inst Invest Sanitaria,CIBER Fisiopatol Obesidad &, Santiago De Compostela 15782, A Coruna, Spain.
   [Varela, Luis; Vazquez, Maria J.; Nogueiras, Ruben; Dieguez, Carlos; Lopez, Miguel] CIBER Fisiopatol Obesidad & Nutr CIBERobn, Santiago De Compostela 15706, Spain.
   [Cordido, Fernando] Univ A Coruna, Dept Med, Sch Hlth Sci, La Coruna 15006, Spain.
   [Cordido, Fernando] Hosp A Coruna, Endocrine Dept, La Coruna 15006, Spain.
   [Vidal-Puig, Antonio] Univ Cambridge, Metab Res Labs, Inst Metab Sci, Addenbrookes Hosp, Cambridge CB2 0QQ, England.
C3 Universidade de Santiago de Compostela; CIBER - Centro de Investigacion
   Biomedica en Red; CIBEROBN; CIBER - Centro de Investigacion Biomedica en
   Red; CIBEROBN; Universidade da Coruna; Complejo Hospitalario
   Universitario A Coruna; Universidade da Coruna; Cambridge University
   Hospitals NHS Foundation Trust; Addenbrooke's Hospital; University of
   Cambridge
RP López, M (corresponding author), Univ Santiago de Compostela, Dept Physiol, Sch Med, Inst Invest Sanitaria,CIBER Fisiopatol Obesidad &, Santiago De Compostela 15782, A Coruna, Spain.
EM m.lopez@usc.es
RI Cordido, Fernando/L-6175-2019; Varela, Luis/ABG-7581-2020; Nogueiras,
   Ruben/AAS-9427-2021; Lopez, Miguel/ABF-4844-2021
OI dieguez, carlos/0000-0002-0919-4337; Varela, Luis/0000-0001-7794-7241;
   Lopez, Miguel/0000-0002-7823-1648; Nogueiras, Ruben/0000-0002-9976-9930;
   Vidal-Puig, Antonio/0000-0003-4220-9577; Cordido,
   Fernando/0000-0003-3528-8174
FU European Community [FP7/2007-2013, 245009, 018734]; Xunta de Galicia [F
   C: PS07/12, C D: PGIDIT06PXIB208063PR, M L: 10PXIB208164PR]; Fondo
   Investigationes Sanitarias [F C: PI051024, PI070413, M L: PS09/01880];
   Ministerio de Educacion y Ciencia [R N: RyC-2008-02219, C D: BFU2008, M
   L: RyC-2007-00211]; Medical Research Council; Welcome Trust
FX The research leading to these results has received funding from the
   European Community's Seventh Framework Programme (FP7/2007-2013) under
   grant agreements no. 245009 (R N, C D, and M L) and no. 018734 (A V P),
   Xunta de Galicia (F C: PS07/12; C D: PGIDIT06PXIB208063PR; M L:
   10PXIB208164PR), Fondo Investigationes Sanitarias (F C: PI051024 and
   PI070413; M L: PS09/01880), Ministerio de Educacion y Ciencia (R N:
   RyC-2008-02219; C D: BFU2008; M L: RyC-2007-00211), Medical Research
   Council (A V P) and Welcome Trust (A V P). CIBER de Fisiopatologia de la
   Obesidad y Nutricion is an initiative of ISCIII.
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NR 224
TC 67
Z9 76
U1 0
U2 19
PU BIOSCIENTIFICA LTD
PI BRISTOL
PA EURO HOUSE, 22 APEX COURT WOODLANDS, BRADLEY STOKE, BRISTOL BS32 4JT,
   ENGLAND
SN 0952-5041
J9 J MOL ENDOCRINOL
JI J. Mol. Endocrinol.
PD APR
PY 2011
VL 46
IS 2
BP R43
EP R63
DI 10.1677/JME-10-0068
PG 21
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 741ZU
UT WOS:000288908500001
PM 21169422
OA Green Submitted, hybrid
DA 2025-06-11
ER

PT J
AU Navalón-Monllor, V
   Soriano-Romaní, L
   Silva, M
   de las Hazas, MCL
   Hernando-Quintana, N
   Diéguez, TS
   Esteve, PM
   Nieto, JA
AF Navalon-Monllor, Victor
   Soriano-Romani, Laura
   Silva, Mariana
   de las Hazas, Maria-Carmen Lopez
   Hernando-Quintana, Natalia
   Dieguez, Teodoro Suarez
   Esteve, Pere Morell
   Nieto, Juan Antonio
TI Microbiota dysbiosis caused by dietetic patterns as a promoter of
   Alzheimer's disease through metabolic syndrome mechanisms
SO FOOD & FUNCTION
LA English
DT Review
ID CHAIN FATTY-ACIDS; GUT MICROBIOTA; INTESTINAL MICROBIOTA; OXIDATIVE
   STRESS; ADIPOSE-TISSUE; AMYLOID-BETA; OBESITY; IMPACT; GLUCOSE; MEMORY
AB Microbiota dysbiosis and metabolic syndrome, consequences of a non-adequate diet, generate a feedback pathogenic state implicated in Alzheimer's disease development. The lower production of short chain fatty acids (SCFAs) under dysbiosis status leads to lipid homeostasis deregulation and decreases Angptl4 release and AMPK activation in the adipose tissue, promoting higher lipid storage (adipocyte hypertrophy) and cholesterol levels. Also, low SCFA generation reduces GPR41 and GPR43 receptor activation at the adipose tissue (increasing leptin release and leptin receptor resistance) and intestinal levels, reducing the release of GLP-1 and YPP. Therefore, lower satiety sensation and energy expenditure occur, promoting a weight gaining environment mediated by higher food intake and lipid storage, developing dyslipemia. In this context, higher glucose levels, together with higher free fatty acids in the bloodstream, promote glycolipotoxicity, provoking a reduction in insulin released, insulin receptor resistance, advanced glycation products (AGEs) and type 2 diabetes. Intestinal dysbiosis and low SCFAs reduce bacterial biodiversity, increasing lipopolysaccharide (LPS)-producing bacteria and intestinal barrier permeability. Higher amounts of LPS pass to the bloodstream (endotoxemia), causing a low-grade chronic inflammatory state characterized by higher levels of leptin, IL-1 & beta;, IL-6 and TNF-& alpha;, together with a reduced release of adiponectin and IL-10. At the brain and neuronal levels, the generated insulin resistance, low-grade chronic inflammation, leptin resistance, AGE production and LPS increase directly impact the secretase enzymes and tau hyperphosphorylation, creating an enabling environment for & beta;-amyloid senile plaque and tau tangled formations and, as a consequence, Alzheimer's initiation, development and maintenance.
C1 [Navalon-Monllor, Victor] Vithas Aguas V Hosp, Carretera Alzira-Tavernes Valldigna CV-50,Km 12, Valencia 46740, Spain.
   [Soriano-Romani, Laura; Nieto, Juan Antonio] Ainia Technol Ctr, Calle Benjamin Franklin 5-11,Parque Tecnol Valenci, E-46980 Valencia, Spain.
   [Silva, Mariana; Esteve, Pere Morell; Nieto, Juan Antonio] Univ Int Valencia VIU, Fac Hlth Sci, Bioact & Nutr Immunol Grp BIOINUT, Calle Pintor Sorolla 21, E-46002 Valencia, Spain.
   [de las Hazas, Maria-Carmen Lopez] CEI UAM CSIC, Inst Madrileno Estudios Avanzados IMDEA Alimentac, Lab Epigenet Lipid Metab, Madrid 28049, Spain.
   [Hernando-Quintana, Natalia] Obispo Polanco Hosp, Ave Ruiz Jarabo S N, Teruel 44002, Spain.
   [Dieguez, Teodoro Suarez] Autonomous Univ State Hidalgo, Inst Hlth Sci, Acad Area Nutr, Abasolo 600,Colonia Ctr,E42000, Pachuca, Hidalgo, Mexico.
C3 Universidad Internacional de Valencia VIU; Consejo Superior de
   Investigaciones Cientificas (CSIC); Universidad Autonoma del Estado de
   Hidalgo
RP Nieto, JA (corresponding author), Ainia Technol Ctr, Calle Benjamin Franklin 5-11,Parque Tecnol Valenci, E-46980 Valencia, Spain.; Nieto, JA (corresponding author), Univ Int Valencia VIU, Fac Hlth Sci, Bioact & Nutr Immunol Grp BIOINUT, Calle Pintor Sorolla 21, E-46002 Valencia, Spain.
EM juanantonio.nieto@campusviu.es
RI Nieto Fuentes, Juan Antonio/AAO-9992-2020; SUAREZ, TEODORO/D-2371-2016;
   Lopez de las Hazas, Maria Carmen/L-3033-2017; Soriano Romani,
   Laura/F-4897-2018; Morell, Pere/AAB-5924-2020
OI Lopez de las Hazas, Maria Carmen/0000-0001-8199-6724; Hernando Quintana,
   Natalia/0000-0001-6505-6097; Soriano Romani, Laura/0000-0001-7513-9224;
   Suarez-Dieguez, Teodoro/0000-0003-3603-7705; Nieto, Juan
   Antonio/0000-0002-9266-0190; Morell, Pere/0000-0001-7201-8806
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NR 155
TC 10
Z9 11
U1 7
U2 28
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PD AUG 14
PY 2023
VL 14
IS 16
BP 7317
EP 7334
DI 10.1039/d3fo01257c
EA JUL 2023
PG 18
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA O8OY6
UT WOS:001032184800001
PM 37470232
DA 2025-06-11
ER

PT J
AU Keerman, M
   Yang, F
   Hu, H
   Wang, J
   Wang, F
   Li, ZY
   Yuan, J
   Yao, P
   Zhang, XM
   Guo, H
   Yang, HD
   He, MA
AF Keerman, Mulatibieke
   Yang, Fen
   Hu, Hua
   Wang, Jing
   Wang, Fei
   Li, Zhaoyang
   Yuan, Jing
   Yao, Ping
   Zhang, Xiaomin
   Guo, Huan
   Yang, Handong
   He, Meian
TI Mendelian randomization study of serum uric acid levels and diabetes
   risk: evidence from the Dongfeng-Tongji cohort
SO BMJ OPEN DIABETES RESEARCH & CARE
LA English
DT Article
DE genetic polymorphisms; type 2 diabetes; genetic epidemiology; metabolic
   syndrome
ID GENOME-WIDE ASSOCIATION; METABOLIC SYNDROME; OXIDATIVE STRESS; URATE
   LEVELS; CAUSAL; METAANALYSIS; TRAITS; LOCI; ATHEROSCLEROSIS;
   HYPERTENSION
AB Objective Limited Mendelian randomization (MR) studies have assessed the causal relationship between serum uric acid levels and diabetes risk. Here we investigated causality between the serum uric acid concentration and diabetes risk in Chinese population.
   Research design and methods The observational analysis, based on the Dongfeng-Tongji prospective cohort (n=15 195) we tested the association of serum uric acid levels with incident diabetes risk. In the instrumental variable analysis, we examined the association of the genetic risk score (GRS) of serum uric acid with diabetes risk in case-control design (2539 cases and 4595 controls) via MR analysis.
   Results During a mean (SD) follow-up of 4.5 (0.5) years, 1156 incident diabetes cases were identified. Compared with those in the lowest quintile of serum uric acid levels, the HRs of incident diabetes were 1.19 (95% CI 0.96 to 1.48), 1.12 (95% CI 0.90 to 1.40), 1.38 (95% CI 1.12 to 1.70), and 1.51 (95% CI 1.23 to 1.87) for Q2, Q3, Q4 and Q5, respectively (P-trend <0.001). The GRS was strongly associated with serum uric acid levels (beta=0.17, 95% CI 0.15 to 0.19; P=2.81x10(-67)). However, no significant association was observed between the GRS and diabetes risk (OR=1.01, 95 CI 0.95 to 1.06; P=0.75).
   Conclusions Even though serum uric acid levels were significantly associated with increased incident diabetes risk, the results did not provide evidence for a causal relationship between them.
C1 [Keerman, Mulatibieke; Yang, Fen; Hu, Hua; Wang, Jing; Wang, Fei; Li, Zhaoyang; Yuan, Jing; Zhang, Xiaomin; Guo, Huan; He, Meian] Huazhong Univ Sci & Technol, Sch Publ Hlth, Dept Occupat & Environm Hlth, Tongji Med Coll, Wuhan, Peoples R China.
   [Keerman, Mulatibieke; Yang, Fen; Hu, Hua; Wang, Jing; Wang, Fei; Li, Zhaoyang; Yuan, Jing; Zhang, Xiaomin; Guo, Huan; He, Meian] Huazhong Univ Sci & Technol, Sch Publ Hlth, State Key Lab Environm & Hlth Incubating, Tongji Med Coll, Wuhan, Peoples R China.
   [Yao, Ping] Huazhong Univ Sci & Technol, Sch Publ Hlth, Dept Nutr & Food Hyg, Tongji Med Coll, Wuhan, Peoples R China.
   [Yang, Handong] Dongfeng Motor Corp Gen Hosp, Dept Cardiovasc Dis, Shiyan, Peoples R China.
C3 Huazhong University of Science & Technology; Huazhong University of
   Science & Technology; Huazhong University of Science & Technology
RP He, MA (corresponding author), Huazhong Univ Sci & Technol, Sch Publ Hlth, Dept Occupat & Environm Hlth, Tongji Med Coll, Wuhan, Peoples R China.; He, MA (corresponding author), Huazhong Univ Sci & Technol, Sch Publ Hlth, State Key Lab Environm & Hlth Incubating, Tongji Med Coll, Wuhan, Peoples R China.
EM hemeian@hotmail.com
RI Zhang, Xiaomin/F-3206-2018; wang, jing/GVT-8700-2022; li,
   yan/GXH-7943-2022; yu, ye/KVB-7532-2024; Zhang, Yuting/JZE-2800-2024
OI Yang, Fen/0000-0002-1970-3270; Wang, Jing/0000-0003-4869-7719
FU National Key R&D Program of China [2017YFC0907501, 2016YFC0900800];
   Program for HUST Academic Frontier Youth Team [2017QYTD18]; National
   Natural Science Foundation [NSFC-81522040, 81473051]
FX The grants from the National Key R&D Program of China (2017YFC0907501
   and 2016YFC0900800), the Program for HUST Academic Frontier Youth Team
   (2017QYTD18), and the National Natural Science Foundation (grant
   NSFC-81522040 and 81473051).
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NR 52
TC 28
Z9 30
U1 0
U2 10
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
EI 2052-4897
J9 BMJ OPEN DIAB RES CA
JI BMJ Open Diab. Res. Care
PD JAN
PY 2020
VL 8
IS 1
AR e000834
DI 10.1136/bmjdrc-2019-000834
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA NU8UG
UT WOS:000573912300024
PM 32111716
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Onat, A
   Aydin, M
   Can, G
   Çelik, E
   Altay, S
   Karagöz, A
   Ademoglu, E
AF Onat, Altan
   Aydin, Mesut
   Can, Gunay
   Celik, Etem
   Altay, Servet
   Karagoz, Ahmet
   Ademoglu, Evin
TI Normal thyroid-stimulating hormone levels, autoimmune activation, and
   coronary heart disease risk
SO ENDOCRINE
LA English
DT Article
DE Autoimmunity; Coronary heart disease risk; Lipoprotein(a); Serum TSH;
   Thyroid status
ID METABOLIC SYNDROME; SERUM CREATININE; TURKISH MEN; LIPOPROTEIN(A);
   ASSOCIATION; ATHEROSCLEROSIS; DYSFUNCTION; POPULATION; DEFINITION;
   COMPLEXES
AB Whether euthyroid status affects cardiovascular disease risk is unclear. We aimed to investigate whether serum thyroid-stimulating hormone (TSH) levels within the normal range are related to the risk of coronary heart disease (CHD). In participants of the Turkish Adult Risk Factor Study (mean age 52.7 +/- A 11.5), in whom TSH was measured in the 2004/05 survey, cross-sectional and longitudinal analyses were performed. Subjects with TSH concentrations < 0.3 and > 4.2 mIU/L were excluded to ensure euthyroid status leaving 956 individuals as the study sample. Mean follow-up was 4.81 +/- A 1.3 years. Men had 18 % lower (p < 0.001) geometric mean TSH levels (1.10 mIU/L) than women (1.35 mIU/L). Correlations of TSH with risk variables were notably virtually absent except weakly positive ones in men with age and systolic blood pressure (SBP). The age-adjusted TSH mid-tertile in men was associated with lowest lipoprotein [Lp](a), apoB, and total cholesterol values. Incident CHD was predicted in Cox regression analyses in men [HR of 2.45 (95 %CI 1.05; 5.74] and in combined sexes by the lowest compared with the highest TSH tertile, after adjustment for age, smoking status, SBP, and LDL-cholesterol. Analysis for combined prevalent and incident CHD stratified by metabolic syndrome (MetS) confirmed the independent association with the lowest TSH tertile in men, specifically in men without MetS. TSH levels within normal range, low due to partial assay failure, may manifest as independent predictors of incident CHD, particularly in middle-aged men. Autoimmune responses involving serum Lp(a) under oxidative stress might be implicated mechanistically.
C1 [Onat, Altan; Can, Gunay] Cerrahpasa Fac Med, TR-34335 Istanbul, Turkey.
   [Aydin, Mesut] Dicle Univ, Fac Med, Diyarbakir, Turkey.
   [Celik, Etem] Etlik Educ Hosp, Ankara, Turkey.
   [Altay, Servet] Siyami Ersek Ctr Cardiovasc Surg, Istanbul, Turkey.
   [Karagoz, Ahmet] Giresun Univ, Giresun, Turkey.
   [Ademoglu, Evin] Istanbul Univ, Istanbul Fac Med, Istanbul, Turkey.
C3 Istanbul University - Cerrahpasa; Istanbul University; Dicle University;
   Dr. Siyami Ersek Cardiac & Vascular Surgery Training & Research
   Hospital; Giresun University; Istanbul University
RP Onat, A (corresponding author), Cerrahpasa Fac Med, Nisbetiye Cad 59-24 Etiler, TR-34335 Istanbul, Turkey.
EM alt_onat@yahoo.com.tr
RI Karagöz, Ahmet/G-2175-2015; Ademoglu, Evin/AAD-8990-2020; Can,
   Günay/AAB-1669-2020; Altay, Servet/C-1387-2018
OI Altay, Servet/0000-0001-7112-3970; Ademoglu, Evin/0000-0003-2933-3119
FU Turkish Society of Cardiology
FX We thank the Turkish Society of Cardiology and the various
   pharmaceutical companies (Istanbul) for financial support of the Turkish
   Adult Risk Factor study over the years.
CR [Anonymous], 1982, CARDIOVASCULAR SURVE
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NR 39
TC 19
Z9 19
U1 1
U2 16
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1355-008X
EI 1559-0100
J9 ENDOCRINE
JI Endocrine
PD FEB
PY 2015
VL 48
IS 1
BP 218
EP 226
DI 10.1007/s12020-014-0269-z
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA CB0RQ
UT WOS:000349334800031
PM 24794068
DA 2025-06-11
ER

PT J
AU Farag, AGA
   Badr, EAE
   Ibrahim, AF
AF Farag, Azza Gaber Antar
   Badr, Eman A. E.
   Ibrahim, Asmaa Fahmy
TI Circadian clock gene expression and polymorphism in non-segmental
   vitiligo
SO MOLECULAR BIOLOGY REPORTS
LA English
DT Article
DE Non-segmental vitiligo; Circadian gene; BMAL1 gene; Lipid profile
ID METABOLIC SYNDROME; CHILDHOOD VITILIGO; BREAST-CANCER; RISK;
   EPIDEMIOLOGY; DISRUPTION; VARIANTS; DISEASES; STRESS
AB BackgroundVitiligo is an acquired and progressive mucocutaneous disease with the damage of functioning epidermal melanocytes. Metabolic syndrome is associated with inflammatory skin diseases incorporating vitiligo. The circadian dysfunction triggers the pathogenesis of metabolic diseases, so our study aimed to determine the relationship between aryl hydrocarbon receptor nuclear translocator-like gene, a ligand-activated transcription factor and sensor of environmental chemicals, expression and polymorphism with non-segmental vitiligo, as well as its effect on lipid profile.MethodsThis case-control study was handled on 50 non-segmental vitiligo patients (generalized (12) and localized type (focal; 24 and acrofacial; 14)) and 50 matched controls. Each subject was proposed for full history taking, clinical examinations, serum lipid profile, and measurement of BMAL1 gene expression in the blood, and BMAL1 rs2279287 polymorphism of DNA extract from whole blood by real time-PCR.ResultsWe identified that total cholesterol, triglyceride, and low-density lipoprotein were significantly higher, but high-density lipoprotein was significantly lower in non-segmental vitiligo patients than in the control group. A significant increase in circadian gene expression in non-segmental vitiligo patients was observed, with more detection of the BMAL1 T/C genotype (92%) than the T/T genotype. There was a significant positive relationship between the level of the circadian gene and the vitiligo patient's age, age of onset, and VIDA Score. The level of the circadian gene at Cutoff >= 1.16 can predict the prognosis of vitiligo with a sensitivity of 78%, specificity of 84%, and accuracy of 81%.ConclusionThe circadian gene has an active role in the progress of non-segmental vitiligo and targeting this gene could have a significant impact on its management.
C1 [Farag, Azza Gaber Antar] Menoufia Univ, Fac Med, Androl & STDs, Shebin Alkom, Egypt.
   [Badr, Eman A. E.] Menoufia Univ, Fac Med, Med Biochem & Mol Biol Dept, Shebin Alkom, Egypt.
   [Ibrahim, Asmaa Fahmy] Menoufia Univ, Natl Liver Inst, Dept Clin & Mol Parasitol, Shebin AlKom, Egypt.
C3 Egyptian Knowledge Bank (EKB); Menofia University; Egyptian Knowledge
   Bank (EKB); Menofia University; Egyptian Knowledge Bank (EKB); Menofia
   University
RP Ibrahim, AF (corresponding author), Menoufia Univ, Natl Liver Inst, Dept Clin & Mol Parasitol, Shebin AlKom, Egypt.
EM azzagaber92@yahoo.com; Ebadr2014@gmail.com;
   asmaafahmy@liver.menofia.edu.eg
RI badr, eman/AAA-6718-2021; Ibrahim, Asmaa/JLL-6827-2023
OI Fahmy, Asmaa/0000-0002-1180-1845; badr, eman/0000-0001-9724-1596
FU Minufiya University
FX No Statement Available
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NR 51
TC 0
Z9 0
U1 0
U2 6
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0301-4851
EI 1573-4978
J9 MOL BIOL REP
JI Mol. Biol. Rep.
PD DEC
PY 2024
VL 51
IS 1
AR 142
DI 10.1007/s11033-023-09109-6
PG 11
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA FI8T9
UT WOS:001145231100016
PM 38236441
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Santos, GL
   Costa, EFD
   Dalla Costa, AP
   Zanesco, AM
   Simoes, MR
   Rogério, F
   Demolin, DMR
   Navarro, CDC
   Velloso, LA
   Francisco, A
   Castilho, RF
AF Santos, Giovanna Leite
   Costa, Ericka Francislaine Dias
   Dalla Costa, Ana Paula
   Zanesco, Ariane Maria
   Simoes, Marcela Reymond
   Rogerio, Fabio
   Demolin, Daniele Masselli Rodrigues
   Navarro, Claudia Daniele Carvalho
   Velloso, Licio Augusto
   Francisco, Annelise
   Castilho, Roger Frigerio
TI Influence of Mitochondrial NAD(P) <SUP>+</SUP> Transhydrogenase (NNT) on
   Hypothalamic Inflammation and Metabolic Dysfunction Induced by a
   High-Fat Diet in Mice
SO HORMONE AND METABOLIC RESEARCH
LA English
DT Article
DE brown adipose tissue; glucose homeostasis; high fat diet; hypothalamic
   inflammation; NADPH; nicotinamide nucleotide transhydrogenase
ID NICOTINAMIDE NUCLEOTIDE TRANSHYDROGENASE; BROWN ADIPOSE-TISSUE; INDUCED
   OBESITY; INSULIN-RESISTANCE; C57BL/6J; MOUSE; EXPRESSION; STRESS; LIVER;
   NADPH
AB The mitochondrial protein NAD(P)(+) transhydrogenase (NNT) has been implicated in the metabolic derangements observed in obesity. Mice with the C57BL/6J genetic background bear a spontaneous mutation in the Nnt gene and are known to exhibit increased susceptibility to diet-induced metabolic disorders. Most of the studies on NNT in the context of diet-induced obesity have compared C57BL/6J mice with other mouse strains, where differences in genetic background can serve as confounding factors. Moreover, these studies have predominantly employed a high-fat diet (HFD) consisting of approximately 60% of calories from fat, which may not accurately mimic real-world fat-rich diets. In this study, we sought to examine the role of NNT in diet-induced hypothalamic inflammation and metabolic syndrome by using a congenic mice model lacking NNT, along with a HFD providing approximately 45% of calories from fat. Our findings indicate that mice lacking NNT were more protected from HFD-induced weight gain but presented a worse performance on glucose tolerance test, albeit not in insulin tolerance test. Interestingly, the brown adipose tissue of HFD-fed Nnt (+/+) mice presented a greater mass and a higher whole-tissue ex-vivo oxygen consumption rate. Also, HFD increased the expression of the inflammatory markers Il1 beta, Tlr4 and Iba1 in the hypothalamus of Nnt (-/-) mice. In conclusion, our study highlights the importance of NNT in the context of diet-induced obesity and metabolic syndrome, indicating its contribution to mitigate hypothalamic inflammation and suggesting its role in the brown adipose tissue increased mass.
C1 [Santos, Giovanna Leite; Costa, Ericka Francislaine Dias; Dalla Costa, Ana Paula; Rogerio, Fabio; Navarro, Claudia Daniele Carvalho; Francisco, Annelise; Castilho, Roger Frigerio] State Univ Campinas UNICAMP, Dept Pathol, BR-13083888 Campinas, SP, Brazil.
   [Zanesco, Ariane Maria; Simoes, Marcela Reymond; Velloso, Licio Augusto] State Univ Campinas UNICAMP, Obes & Comorbid Res Ctr, Lab Cell Signaling, Campinas, Brazil.
   [Demolin, Daniele Masselli Rodrigues] State Univ Campinas UNICAMP, Multidisciplinary Ctr Biol Invest Lab Anim Sci, Campinas, Brazil.
   [Francisco, Annelise] Lund Univ, Dept Expt Med Sci, Solvegatan 19, S-22184 Lund, Sweden.
C3 Universidade Estadual de Campinas; Universidade Estadual de Campinas;
   Universidade Estadual de Campinas; Lund University
RP Francisco, A; Castilho, RF (corresponding author), State Univ Campinas UNICAMP, Dept Pathol, BR-13083888 Campinas, SP, Brazil.; Francisco, A (corresponding author), Lund Univ, Dept Expt Med Sci, Solvegatan 19, S-22184 Lund, Sweden.
EM annelisef28@gmail.com; rogerc@unicamp.br
RI Zanesco, Ariane/AAO-5196-2021; Francisco, Annelise/AAQ-8826-2021;
   Castilho, Roger/G-3906-2012; Velloso, Licio/AAJ-3778-2020; Costa,
   Ericka/HNJ-0767-2023; Rogerio, Fabio/B-9391-2013
OI Francisco, Annelise/0000-0001-6729-8807
FU Conselho Nacional de Desenvolvimento Cientifico e Tecnologico
   [305231/2022-7, INCT-SC 406020/2022-1]; Fundacao de Amparo a Pesquisa do
   Estado de Sao Paulo [17/17728-8, 23/00229-0, 23/06469-2]; Coordenacao de
   Aperfeicoamento de Pessoal de Nivel Superior [CAPES/STINT
   88887.724090/2022-00]
FX Conselho Nacional de Desenvolvimento Cientifico e Tecnologico |
   305231/2022-7, INCT-SC 406020/2022-1 | Fundacao de Amparo a Pesquisa do
   Estado de Sao Paulo | 17/17728-8, 23/00229-0, 23/06469-2 | Coordenacao
   de Aperfeicoamento de Pessoal de Nivel Superior | CAPES/STINT
   88887.724090/2022-00
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NR 68
TC 0
Z9 0
U1 1
U2 1
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA Oswald-Hesse-Strasse 50, D-70469 STUTTGART, GERMANY
SN 0018-5043
EI 1439-4286
J9 HORM METAB RES
JI Horm. Metab. Res.
PD MAR
PY 2025
VL 57
IS 03
BP 199
EP 207
DI 10.1055/a-2420-6549
EA OCT 2024
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA Z4V5U
UT WOS:001346215300001
PM 39481390
DA 2025-06-11
ER

PT J
AU Yamamoto, K
   Ikeya, T
   Okuyama, S
   Fukuda, K
   Kobayashi, D
AF Yamamoto, Kazuki
   Ikeya, Takashi
   Okuyama, Shuhei
   Fukuda, Katsuyuki
   Kobayashi, Daiki
TI Association between the Frequency of Daily Toothbrushing and Development
   of Nonalcoholic Fatty Liver Disease
SO DIGESTIVE DISEASES
LA English
DT Article
DE Toothbrushing; Nonalcoholic fatty liver disease; Metabolic syndrome;
   Periodontal disease; Porphyromonas gingivalis
ID 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1; INTESTINAL BACTERIAL
   OVERGROWTH; METABOLIC SYNDROME; PORPHYROMONAS-GINGIVALIS;
   CARDIOVASCULAR-DISEASE; OXIDATIVE STRESS; OBESITY; PERIODONTITIS;
   INFLAMMATION; BEHAVIOR
AB Background & Aim: This study aimed to evaluate the association between the frequency of daily toothbrushing and the development of nonalcoholic fatty liver disease (NAFLD). Methods: A retrospective longitudinal study was conducted from 2005 to 2012 at the Center for Preventive Medicine at St. Luke's International Hospital, Japan. Data on all participants who underwent a health checkup during the study period were collected. NAFLD was diagnosed by abdominal ultrasonography, and all participants who were diagnosed with NAFLD at the time of their initial visit, consumed alcohol in any amount, or had received only one health checkup were excluded. The questionnaire for the frequency of daily toothbrushing was conducted as part of health checkups. The primary outcome was the risk of developing NAFLD according to the frequency of daily toothbrushing (1-2 times a day or 3 times a day) compared to those who brush teeth once or less than once a day. Results: Data were collected from 25,804 people. A total of 3,289 (12.7%) participants developed NAFLD. The mean age was 45.2 years, and 6,901 (26.7%) of the participants were male. The risk of developing NAFLD significantly decreased with increased frequency of daily toothbrushing. Adjusted odds ratios (ORs) are as follows: brushing teeth 1-2 times a day (OR: 0.85, 95% confidence interval [CI]: 0.77-0.95) and 3 times a day (OR: 0.74, 95% CI: 0.67-0.82). Conclusion: Frequent toothbrushing was shown to significantly reduce the risk of developing NAFLD.
C1 [Yamamoto, Kazuki; Ikeya, Takashi; Okuyama, Shuhei; Fukuda, Katsuyuki] St Lukes Int Hosp, Dept Gastroenterol, Tokyo, Japan.
   [Kobayashi, Daiki] St Lukes Int Hosp, Dept Med, Tokyo, Japan.
   [Kobayashi, Daiki] St Lukes Grad Sch Publ Hlth, Dept Epidemiol, Tokyo, Japan.
   [Kobayashi, Daiki] Fujita Hlth Univ, Dept Med, Toyoake, Aichi, Japan.
C3 St. Luke's International Hospital; St. Luke's International Hospital;
   Fujita Health University
RP Yamamoto, K (corresponding author), St Lukes Int Hosp, Dept Gastroenterol, Tokyo, Japan.
EM kazuyama@luke.ac.jp
RI Yamamoto, Kazuki/IXW-6531-2023
OI Yamamoto, Kazuki/0000-0001-6614-2763
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NR 50
TC 7
Z9 7
U1 0
U2 8
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0257-2753
EI 1421-9875
J9 DIGEST DIS
JI Dig. Dis.
PD NOV
PY 2021
VL 39
IS 6
BP 646
EP 652
DI 10.1159/000514930
EA FEB 2021
PG 7
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA XL4HX
UT WOS:000700009600001
PM 33535206
DA 2025-06-11
ER

PT J
AU Ramli, ESM
   Sukalingam, K
   Kamaruzzaman, MA
   Soelaiman, IN
   Pang, KL
   Chin, KY
AF Ramli, Elvy Suhana Mohd
   Sukalingam, Kumeshini
   Kamaruzzaman, Mohd Amir
   Soelaiman, Ima Nirwana
   Pang, Kok-Lun
   Chin, Kok-Yong
TI Direct and Indirect Effect of Honey as a Functional Food Against
   Metabolic Syndrome and Its Skeletal Complications
SO DIABETES METABOLIC SYNDROME AND OBESITY
LA English
DT Review
DE antioxidant; anti-inflammatory; bone; hypertension; hyperlipidemia;
   hyperglycemia; obesity; osteoporosis
ID BONE-MINERAL DENSITY; GLYCATION END-PRODUCTS; HIGH-FAT DIET;
   OBESITY-RELATED HYPERTENSION; CARDIOVASCULAR RISK-FACTORS;
   ACTIVATED-RECEPTOR-GAMMA; MESENCHYMAL STEM-CELLS; HIGH BLOOD-PRESSURE;
   SUGAR-FREE DIET; OXIDATIVE STRESS
AB Metabolic syndrome (MetS) refers to the simultaneous presence of hypertension, hyperglycemia, dyslipidemia and/or visceral obesity, which predisposes a person to cardiovascular diseases and diabetes. Evidence suggesting the presence of direct and indirect associations between MetS and osteoporosis is growing. Many studies have reported the beneficial effects of polyphenols in alleviating MetS in in vivo and in vitro models through their antioxidant and anti-inflammation actions. This review aims to summarize the effects of honey (based on unifloral and multi-floral nectar sources) on bone metabolism and each component of MetS. A literature search was performed using the PubMed and Scopus databases using specific search strings. Original studies related to components of MetS and bone, and the effects of honey on components of MetS and bone were included. Honey polyphenols could act synergistically in alleviating MetS by preventing oxidative damage and inflammation. Honey intake is shown to reduce blood glucose levels and prevent excessive weight gain. It also improves lipid metabolism by reducing total cholesterol, triglycerides and low-density lipoprotein, as well as increasing high-density lipoprotein. Honey can prevent bone loss by reducing the adverse effects of MetS on bone homeostasis, apart from its direct action on the skeletal system. In conclusion, honey supplementation could be integrated into the management of MetS and MetS-induced bone loss as a preventive and adjunct therapeutic agent.
C1 [Ramli, Elvy Suhana Mohd; Sukalingam, Kumeshini; Kamaruzzaman, Mohd Amir] Univ Kebangsaan Malaysia, Fac Med, Dept Anat, Med Ctr, Level 18,Preclin Bldg,Jalan Yaacob Latif, Kuala Lumpur 56000, Malaysia.
   [Soelaiman, Ima Nirwana; Pang, Kok-Lun; Chin, Kok-Yong] Univ Kebangsaan Malaysia, Fac Med, Dept Pharmacol, Med Ctr, Kuala Lumpur, Malaysia.
C3 Universiti Kebangsaan Malaysia; Universiti Kebangsaan Malaysia
RP Ramli, ESM (corresponding author), Univ Kebangsaan Malaysia, Fac Med, Dept Anat, Med Ctr, Level 18,Preclin Bldg,Jalan Yaacob Latif, Kuala Lumpur 56000, Malaysia.
EM elvysuhana@ukm.edu.my
RI Kamaruzzaman, Mohd/ABB-8881-2020; Pang, Kok/W-2157-2019; Soelaiman,
   Ima/C-4289-2017; Chin, Kok-Yong/B-6309-2015
OI Chin, Kok-Yong/0000-0001-6628-1552; Pang, Kok Lun/0000-0003-2219-6297
FU Ministry of Education, Malaysia [FRGS/1/2019/SKK06/UKM/03/2]
FX The authors thank the Ministry of Education, Malaysia for funding the
   researchers through FRGS/1/2019/SKK06/UKM/03/2.
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NR 213
TC 16
Z9 16
U1 1
U2 10
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-7007
J9 DIABET METAB SYND OB
JI Diabetes Metab. Syndr. Obes.
PY 2021
VL 14
BP 241
EP 255
DI 10.2147/DMSO.S291828
PG 15
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA QF9EJ
UT WOS:000617191100001
PM 33500644
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Yasuda, E
   Nakamura, R
   Matsugi, R
   Goto, S
   Ikenaga, Y
   Kuroda, K
   Nakamura, S
   Katsuki, Y
   Katsuki, T
AF Yasuda, Emi
   Nakamura, Ryuichi
   Matsugi, Ryo
   Goto, Shinsuke
   Ikenaga, Yasunori
   Kuroda, Kazunari
   Nakamura, Syunsuke
   Katsuki, Yasuo
   Katsuki, Tatsuo
TI Association between the severity of symptomatic knee osteoarthritis and
   cumulative metabolic factors
SO AGING CLINICAL AND EXPERIMENTAL RESEARCH
LA English
DT Article
DE Symptomatic knee osteoarthritis; Metabolic syndrome; Obesity;
   Hypertension; Dyslipidemia; Hyperglycemia; Mechanical stress
ID BODY-MASS INDEX; CARDIOVASCULAR-DISEASE; MEDITERRANEAN DIET; FOLLOW-UP;
   PAIN; PREVENTION; RISK; GUIDELINES; MANAGEMENT; COMPONENTS
AB Background The association between cumulative metabolic syndrome (MS) factors and knee osteoarthritis (KOA) has been highlighted over the past two decades.
   Aims To clarify the relationship between cumulative MS factors and symptomatic KOA.
   Methods A cross-sectional survey involving 119 women aged 45-88 years who were scheduled to undergo knee surgery was conducted. They were stratified into tertiles of symptoms as assessed by the Japanese Orthopedic Association score for KOA. Multinomial logistic regressions were performed using the severity of symptomatic KOA as the dependent variable and each MS factor or the cumulative MS factors as the independent variables.
   Results Logistic regression analyses were performed with the upper tertile of stratified symptoms of subjects used as the reference group. After adjustment for confounders, KOA patients who had two (p = 0.004) or three or more (p < 0.0001) MS factors were significantly more likely to have severe symptoms compared to those who had no MS factors. MS factors excluding obesity were similarly analyzed. Even after additional adjustment for body mass index (BMI), KOA patients who had two or more (p = 0.005) MS factors were significantly more likely to have severe symptoms.
   Conclusion Among KOA female patients diagnosed using radiographic definition, the severity of symptomatic KOA was significantly associated with hypertension, dyslipidemia, and the number of MS factors after adjustment for age, BMI, strength of the knee extensor, and Kellgren-Lawrence grade. The severity of radiographic KOA was not associated with any MS factor or cumulative MS factors.
C1 [Yasuda, Emi; Goto, Shinsuke; Ikenaga, Yasunori] Yawata Med Ctr, Dept Rehabil, I-12-7 Yawata, Komatsu, Ishikawa 9238551, Japan.
   [Nakamura, Ryuichi; Kuroda, Kazunari; Katsuki, Yasuo] Yawata Med Ctr, Dept Orthoped Surg, Komatsu, Ishikawa 9238551, Japan.
   [Matsugi, Ryo] Yawata Med Ctr, Hokuriku Inst Wellness & Sports Sci, Komatsu, Ishikawa 9238601, Japan.
   [Nakamura, Syunsuke] Fukuoka Sanno Hosp, Dept Orthoped Surg, Fukuoka 8110115, Japan.
   [Katsuki, Tatsuo] Yawata Med Ctr, Dept Cardiol, Komatsu, Ishikawa 9238551, Japan.
RP Yasuda, E (corresponding author), Yawata Med Ctr, Dept Rehabil, I-12-7 Yawata, Komatsu, Ishikawa 9238551, Japan.
EM ebiyasu67@yahoo.co.jp
OI /0000-0001-6381-0025; Nakamura, Ryuichi/0000-0002-1743-7749
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NR 55
TC 19
Z9 24
U1 0
U2 7
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1594-0667
EI 1720-8319
J9 AGING CLIN EXP RES
JI Aging Clin. Exp. Res.
PD MAY
PY 2018
VL 30
IS 5
BP 481
EP 488
DI 10.1007/s40520-017-0808-6
PG 8
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA GD6AF
UT WOS:000430590100009
PM 28762210
DA 2025-06-11
ER

PT J
AU El-Bassossy, HM
   Shaltout, HA
AF El-Bassossy, Hany M.
   Shaltout, Hossam A.
TI Allopurinol alleviates hypertension and proteinuria in high fructose,
   high salt and high fat induced model of metabolic syndrome
SO TRANSLATIONAL RESEARCH
LA English
DT Article
ID URIC-ACID; ANGIOTENSIN-II; VASCULAR COMPLICATIONS;
   CARDIOVASCULAR-DISEASE; OXIDATIVE STRESS; PROXIMAL TUBULE; RENAL SODIUM;
   RATS; TRANSPORTERS; PATHOGENESIS
AB Metabolic syndrome (MetS) is a global epidemic associated with great socioeconomic and public health impact. Prevalence of the MetS has been consistently associated with cardiorenal mortality. The objective of this study was to investigate the effect of allopurinol treatment on various components of an established MetS in rats. In a first group, MetS was induced in male Wistar rats by the addition of 10% fructose to drinking water and placing the rats on high-fat and high-salt diet for 12 weeks (M). In the second group, MetS was induced for 12 weeks plus allopurinol administration (20 mg/kg/d) orally for 4 weeks starting at week 9 (MA). The third group was control (C) group that received a normal diet. The M group had higher blood pressure (BP) (85.5 +/- 3.17 vs 66.1 +/- 3.3 mm Hg) and proteinuria (1.8 +/- 0.3 vs 0.59 +/- 0.13 g/d) compared with the C group. Allopurinol reversed the BP and proteinuria in MA rats to the control level. Allopurinol administration suppressed the low-grade inflammation associated with MetS and reversed the increases in kidney transforming growth factor beta and urine 8-isoprostane acid observed in the MA group to control levels. In addition, allopurinol reduced angiotensin II and angiotensin receptor type 1 levels in the kidney of MA rats compared with the M group. The administration of allopurinol for short term in an established MetS model reduced features of the MetS especially hypertension and proteinuria. Addition of allopurinol to the therapy of MetS may provide superior means to alleviate hypertension and protein uria associated with MetS.
C1 [El-Bassossy, Hany M.] King Abdulaziz Univ, Dept Pharmacol, Fac Pharm, Jeddah 21589, Saudi Arabia.
   Zagazig Univ, Fac Pharm, Dept Pharmacol, Zagazig, Egypt.
   Wake Forest Univ, Bowman Gray Sch Med, Hypertens & Vasc Res Ctr, Winston Salem, NC USA.
   Wake Forest Univ, Bowman Gray Sch Med, Dept Obstet & Gynecol, Winston Salem, NC 27103 USA.
C3 King Abdulaziz University; Egyptian Knowledge Bank (EKB); Zagazig
   University; Wake Forest University; Wake Forest Baptist Medical Center;
   Wake Forest University; Wake Forest Baptist Medical Center
RP El-Bassossy, HM (corresponding author), King Abdulaziz Univ, Dept Pharmacol, Fac Pharm, POB 80260, Jeddah 21589, Saudi Arabia.
EM helbassossy@kau.edu.sa
RI El-Bassossy, Hany/NKQ-3705-2025; Shaltout, Hossam/F-6903-2013;
   El-Bassossy, Hany/I-1576-2012
OI Shaltout, Hossam/0000-0001-7948-3815; El-Bassossy,
   Hany/0000-0002-6838-6945
FU Deanship of Scientific Research (DSR), King Abdulaziz University, Jeddah
   [166-120-D1435]; DSR
FX This work was funded by the Deanship of Scientific Research (DSR), King
   Abdulaziz University, Jeddah, under grant no. 166-120-D1435. The
   authors, therefore, acknowledge with thanks DSR technical and financial
   support.
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NR 45
TC 35
Z9 37
U1 0
U2 11
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1931-5244
EI 1878-1810
J9 TRANSL RES
JI Transl. Res.
PD MAY
PY 2015
VL 165
IS 5
BP 621
EP 630
DI 10.1016/j.trsl.2014.11.008
PG 10
WC Medical Laboratory Technology; Medicine, General & Internal; Medicine,
   Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology; General & Internal Medicine; Research &
   Experimental Medicine
GA CH6JP
UT WOS:000354143200007
PM 25528722
DA 2025-06-11
ER

PT J
AU Liu, XL
   Zhang, JY
   Ming, YN
   Chen, XY
   Zeng, MD
   Mao, YM
AF Liu, Xiaolin
   Zhang, Jingyi
   Ming, Yanan
   Chen, Xiaoyu
   Zeng, Minde
   Mao, Yimin
TI The aggravation of mitochondrial dysfunction in nonalcoholic fatty liver
   disease accompanied with type 2 diabetes mellitus
SO SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
LA English
DT Article
DE carnitine palmitoyltransferase; diabetes mellitus; mitochondrial complex
   IV; mitochondrial disease; non-alcoholic fatty liver disease
ID METABOLIC SYNDROME; OXIDATIVE STRESS; FOLLOW-UP; STEATOHEPATITIS; NAFLD;
   PROGRESSION; SURVIVAL; MODEL; NASH; RAT
AB Objective. Nonalcoholic fatty liver disease (NAFLD) is a mitochondrial disease associated with the metabolic syndrome, but few data are available on the mitochondrial dysfunction of NAFLD after the development of type 2 diabetes mellitus (T2DM). We aimed to identify the changes of mitochondrial function in rat livers when T2DM develops after NAFLD. Material and methods. Rat models of nonalcoholic fatty liver (NAFL) and T2DM were established using high-fat diet and streptozocin. Mitochondria were isolated from the livers. The levels of reactive oxygen species (ROS) and mRNA and protein levels of mitochondrial complex IV (COX IV) and carnitine palmitoyltransferase-1 (CPT-1) were assessed in rat livers. The mitochondrial membrane potential (MP), and the enzyme activities of COX IV and CPT-1 were measured in isolated mitochondria. Results. There were increased ROS, decreased mitochondrial MP, and reduced COX IV and CPT-1 activity in the NAFL and T2DM groups compared with controls (p < 0.05). Compared with NAFL, the T2DM group had higher ROS levels and lower enzyme activity (p < 0.05), but showed no difference in mitochondrial MP. Although COX IV and CPT-1 expression levels in liver decreased in NAFL and T2DM, there was no significant difference between two groups. Conclusion. This study first identified progressively impaired mitochondrial respiratory chain and beta-oxidation in NAFLD when T2DM develops, inducing overproduction of ROS, and finally triggering a vicious circle that leads to the aggravation of mitochondrial dysfunction in NAFLD after development of T2DM.
C1 [Liu, Xiaolin; Zhang, Jingyi; Ming, Yanan; Chen, Xiaoyu; Zeng, Minde; Mao, Yimin] Shanghai Jiao Tong Univ, Div Gastroenterol & Hepatol, Renji Hosp, Sch Med,Shanghai Inst Digest Dis, Shanghai 200000, Peoples R China.
C3 Shanghai Jiao Tong University
RP Mao, YM (corresponding author), Shanghai Jiao Tong Univ, Div Gastroenterol & Hepatol, Renji Hosp, Sch Med,Shanghai Inst Digest Dis, Huangpu Dist Shandong Rd 145, Shanghai 200000, Peoples R China.
EM maoym11968@163.com
RI Ming, Yanan/HZI-6563-2023; Chen, Xiaoyu/JQL-1125-2023; Mao,
   Yimin/AAC-9226-2021
FU Major Project of National Twelfth Five Plan [2012ZX09303-001,
   2013ZX10002004]
FX This work was supported by the Major Project of National Twelfth Five
   Plan (2012ZX09303-001, 2013ZX10002004).
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NR 30
TC 13
Z9 18
U1 0
U2 11
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0036-5521
EI 1502-7708
J9 SCAND J GASTROENTERO
JI Scand. J. Gastroenterol.
PY 2015
VL 50
IS 9
BP 1152
EP 1159
DI 10.3109/00365521.2015.1030687
PG 8
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA CR4RE
UT WOS:000361323900012
PM 25877002
DA 2025-06-11
ER

PT J
AU Tadros, EM
   Frank, N
   De Witte, FG
   Boston, RC
AF Tadros, Elizabeth M.
   Frank, Nicholas
   De Witte, Fiamma Gomez
   Boston, Raymond C.
TI Effects of intravenous lipopolysaccharide infusion on glucose and
   insulin dynamics in horses with equine metabolic syndrome
SO AMERICAN JOURNAL OF VETERINARY RESEARCH
LA English
DT Article
ID MINIMAL-MODEL; ENDOTHELIAL DYSFUNCTION; INFLAMMATORY RESPONSES; LIPID
   CONCENTRATIONS; SENSITIVITY; RESISTANCE; TOLERANCE; LAMINITIS; OBESITY;
   PONIES
AB Objective-To test the hypothesis that glucose and insulin dynamics during endotoxemia differ between healthy horses and horses with equine metabolic syndrome (EMS).
   Animals-6 healthy adult mares and 6 horses with EMS.
   Procedures-Each horse randomly received an IV infusion of lipopolysaccharide (20 ng/kg [in 60 mL of sterile saline {0.9% NaCl} solution]) or saline solution, followed by the other treatment after a 7-day washout period. Baseline insulin-modified frequently sampled IV glucose tolerance tests were performed 27 hours before and then repeated at 0.5 and 21 hours after infusion. Results were assessed via minimal model analysis and area under the curve values for plasma glucose and serum insulin concentrations.
   Results-Lipopolysaccharide infusion decreased insulin sensitivity and increased area under the serum insulin concentration curve (treatment X time) in both healthy and EMS-affected horses, compared with findings following saline solution administration. The magnitude of increase in area under the plasma glucose curve following LPS administration was greater for the EMS-affected horses than it was for the healthy horses. Horses with EMS that received LPS or saline solution infusions had decreased insulin sensitivity over time.
   Conclusions and Clinical Relevance-Glucose and insulin responses to endotoxemia differed between healthy horses and horses with EMS, with greater loss of glycemic control in EMS-affected horses. Horses with EMS also had greater derangements in glucose and insulin homeostasis that were potentially stress induced. It may therefore be helpful to avoid exposure of these horses to stressful situations.
C1 [Tadros, Elizabeth M.; Frank, Nicholas; De Witte, Fiamma Gomez] Univ Tennessee, Dept Large Anim Clin Sci, Coll Vet Med, Knoxville, TN 37996 USA.
   [Boston, Raymond C.] Univ Penn, Sch Vet Med, Dept Clin Studies, New Bolton Ctr, Kennett Sq, PA 19348 USA.
C3 University of Tennessee System; University of Tennessee Knoxville; UT
   Institute of Agriculture; University of Pennsylvania
RP Frank, N (corresponding author), Univ Tennessee, Dept Large Anim Clin Sci, Coll Vet Med, Knoxville, TN 37996 USA.
EM nicholas.frank@tufts.edu
FU University of Tennessee Center of Excellence in Livestock Diseases and
   Human Health; Charles and Julie Wharton Fellowship; Wells Graduate
   Student Fellowship
FX Supported by the University of Tennessee Center of Excellence in
   Livestock Diseases and Human Health, the Charles and Julie Wharton
   Fellowship, and the Wells Graduate Student Fellowship.
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NR 56
TC 8
Z9 9
U1 0
U2 22
PU AMER VETERINARY MEDICAL ASSOC
PI SCHAUMBURG
PA 1931 N MEACHAM RD SUITE 100, SCHAUMBURG, IL 60173-4360 USA
SN 0002-9645
EI 1943-5681
J9 AM J VET RES
JI Am. J. Vet. Res.
PD JUL
PY 2013
VL 74
IS 7
BP 1020
EP 1029
DI 10.2460/ajvr.74.7.1020
PG 10
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA 177WQ
UT WOS:000321406500011
PM 23802674
OA Bronze
DA 2025-06-11
ER

PT J
AU Kempf, K
   Rose, B
   Herder, C
   Haastert, B
   Fusbahn-Laufenburg, A
   Reifferscheid, A
   Scherbaum, WA
   Kolb, H
   Martin, S
AF Kempf, K.
   Rose, B.
   Herder, C.
   Haastert, B.
   Fusbahn-Laufenburg, A.
   Reifferscheid, A.
   Scherbaum, W. A.
   Kolb, H.
   Martin, S.
TI The metabolic syndrome sensitizes leukocytes for glucose-induced immune
   gene expression
SO JOURNAL OF MOLECULAR MEDICINE-JMM
LA English
DT Article
DE MetS; hyperglycemia; oral glucose challenge
ID FACTOR-KAPPA-B; OXIDATIVE STRESS; INSULIN-RESISTANCE; MONONUCLEAR-CELLS;
   HEALTHY-SUBJECTS; BLOOD MONOCYTES; TNF-ALPHA; IKK-BETA; HYPERGLYCEMIA;
   GENERATION
AB Definitions of the metabolic syndrome (MetS) include obesity, dyslipidemia, elevated levels of fasting blood glucose, and blood pressure as criteria, but it is also known that the MetS is associated with chronic, subclinical inflammation. Hyperglycemia (fasting and postprandial) may be important in exacerbating this proinflammatory state. We aimed to assess the impact of oral glucose challenge and in vitro glucose-stimulation on gene expression and secretion of inflammatory parameters in peripheral blood leukocytes and to investigate whether presence of the MetS could "prime" leukocytes to up-regulate proinflammatory markers in response to glucose. Using quantitative real-time PCR, we could show that the expression of intereellular adhesion molecule 1 (ICAM-1), tumor necrosis factor alpha (TNF-alpha), and interleukin 6 (IL-6) significantly increased in peripheral blood leukocytes from "MetS" subjects (n=39) compared to "no MetS" subjects (n=35) 2 h after an oral glucose tolerance test (ICAM-1 +52%, TNF-alpha +107%, and IL-6 +38%) and also in vitro after 72 h cultivation in high-glucose medium (ICAM-1 +74%, TNF-alpha +71%, and IL-6 +44%). Using ELTSA and Luminex technique, we further observed a trend towards increased immune mediator concentrations in the corresponding cell culture supernatants from MetS patients (ICAM-1 +21%, TNF-alpha +31%, and IL-6 +175%). Thus, the MetS may support peripheral inflammation by sensitizing leukocytes to up-regulate proinflammatory markers in response to glucose, which in turn increases the risk for type-2 diabetes mellitus and cardiovascular disease.
C1 Univ Dusseldorf, Leibniz Inst, German Diabet Clin, German Diabet Ctr, D-40225 Dusseldorf, Germany.
   Univ Dusseldorf, Leibniz Inst, Inst Biometr & Epidemiol, German Diabet Ctr, D-40225 Dusseldorf, Germany.
   Henkel KGaA, Med Corp Dept, Dusseldorf, Germany.
C3 Heinrich Heine University Dusseldorf; Leibniz Association; Deutsches
   Diabetes-Zentrum (DDZ); Leibniz Association; Deutsches Diabetes-Zentrum
   (DDZ); Heinrich Heine University Dusseldorf; Henkel
RP Kempf, K (corresponding author), Univ Dusseldorf, Leibniz Inst, German Diabet Clin, German Diabet Ctr, Hennekamp 65, D-40225 Dusseldorf, Germany.
EM Kerstin.Kempf@ddz.uni-duesseldorf.de
OI Nowotny, Bettina/0000-0002-0671-9644
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NR 28
TC 40
Z9 40
U1 0
U2 2
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0946-2716
EI 1432-1440
J9 J MOL MED
JI J. Mol. Med.
PD APR
PY 2007
VL 85
IS 4
BP 389
EP 396
DI 10.1007/s00109-006-0132-7
PG 8
WC Genetics & Heredity; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Genetics & Heredity; Research & Experimental Medicine
GA 163IB
UT WOS:000246152200009
PM 17160670
DA 2025-06-11
ER

PT J
AU Monteiro, R
   Teixeira, D
   Calhau, C
AF Monteiro, Rosario
   Teixeira, Diana
   Calhau, Conceicao
TI Estrogen Signaling in Metabolic Inflammation
SO MEDIATORS OF INFLAMMATION
LA English
DT Review
ID NF-KAPPA-B; 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1;
   NECROSIS-FACTOR-ALPHA; HORMONE-REPLACEMENT THERAPY; ADIPOSE-TISSUE
   MACROPHAGES; BLOOD MONONUCLEAR-CELLS; DEFICIENT ARKO MICE; C-REACTIVE
   PROTEIN; SEX STEROID ACTION; INSULIN-RESISTANCE
AB There is extensive evidence supporting the interference of inflammatory activation with metabolism. Obesity, mainly visceral obesity, is associated with a low-grade inflammatory state, triggered by metabolic surplus where specialized metabolic cells such as adipocytes activate cellular stress initiating and sustaining the inflammatory program. The increasing prevalence of obesity, resulting in increased cardiometabolic risk and precipitating illness such as cardiovascular disease, type 2 diabetes, fatty liver, cirrhosis, and certain types of cancer, constitutes a good example of this association. The metabolic actions of estrogens have been studied extensively and there is also accumulating evidence that estrogens influence immune processes. However, the connection between these two fields of estrogen actions has been underacknowledged since little attention has been drawn towards the possible action of estrogens on the modulation of metabolism through their anti-inflammatory properties. In the present paper, we summarize knowledge on the modification inflammatory processes by estrogens with impact on metabolism and highlight major research questions on the field. Understanding the regulation of metabolic inflammation by estrogens may provide the basis for the development of therapeutic strategies to the management of metabolic dysfunctions.
C1 [Monteiro, Rosario; Teixeira, Diana; Calhau, Conceicao] Univ Porto, Fac Med, Med Invest Ctr, Dept Biochem, P-4200319 Oporto, Portugal.
   [Calhau, Conceicao] Ctr Res Hlth Technol & Informat Syst CINTESIS, P-4200450 Oporto, Portugal.
C3 Universidade do Porto; Universidade do Porto
RP Monteiro, R (corresponding author), Univ Porto, Fac Med, Med Invest Ctr, Dept Biochem, P-4200319 Oporto, Portugal.
EM rosariom@med.up.pt
RI Teixeira, Diana/GNM-9140-2022; Calhau, Conceição/L-8041-2013; Monteiro,
   Rosário/R-1387-2018; Teixeira, Diana/K-2882-2015
OI Teixeira, Diana/0000-0002-2162-1450; Calhau,
   Conceicao/0000-0001-9567-3379; Monteiro, Rosario/0000-0003-1552-5507
FU Fundacao para a Ciencia e a Tecnologia (Fundo Social Europeu, Programa
   Operacional Potencial Humano da EU (POPH)) [PEst-OE/SAU/UI0038/2014,
   SFRH/BPD/40110/2007, SFRH/BD/64691/2009]; Fundação para a Ciência e a
   Tecnologia [SFRH/BD/64691/2009, SFRH/BPD/40110/2007,
   PEst-OE/SAU/UI0038/2014] Funding Source: FCT
FX This work was supported by Fundacao para a Ciencia e a Tecnologia (Fundo
   Social Europeu, Programa Operacional Potencial Humano da EU (POPH);
   PEst-OE/SAU/UI0038/2014; SFRH/BPD/40110/2007; SFRH/BD/64691/2009).
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NR 215
TC 147
Z9 161
U1 0
U2 16
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 0962-9351
EI 1466-1861
J9 MEDIAT INFLAMM
JI Mediat. Inflamm.
PY 2014
VL 2014
AR 615917
DI 10.1155/2014/615917
PG 20
WC Cell Biology; Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Immunology
GA AT6GR
UT WOS:000345038100001
PM 25400333
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Chen, YB
   Jiang, Q
   Xing, XW
   Yuan, T
   Li, PP
AF Chen, Yibing
   Jiang, Qian
   Xing, Xiaowei
   Yuan, Tao
   Li, Pingping
TI Clinical research progress on β-cell dysfunction in T2DM development in
   the Chinese population
SO REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
LA English
DT Review
DE T2DM; Chinese; beta-cell function; Ethnicities; Risk factors; Treatments
ID TYPE-2 DIABETES-MELLITUS; IMPAIRED FASTING GLUCOSE; INSULIN SENSITIVITY;
   GLYCEMIC CONTROL; ETHNIC-DIFFERENCES; OXIDATIVE STRESS; PANCREATIC
   ALPHA; LIFE-STYLE; METFORMIN MONOTHERAPY; CARDIOMETABOLIC RISK
AB The prevalence of type-2 diabetes mellitus (T2DM) has increased over 10-fold in the past 40 years in China, which now has the largest T2DM population in the world. Insulin resistance and beta-cell dysfunction are the typical features of T2DM. Although both factors play a role, decreased beta-cell function and beta-cell mass are the predominant factors for progression to T2DM. Considering the differences between Chinese T2DM patients and those of other ethnicities, it is important to characterize beta-cell dysfunction in Chinese patients during T2DM progression. Herein, we reviewed the studies on the relationships between beta-cell function and T2DM progression in the Chinese population and discussed the differences among individuals of varying ethnicities. Meanwhile, we summarized the risk factors and current treatments of T2DM in Chinese individuals and discussed their impacts on beta-cell function with the hope of identifying a better T2DM therapy.Graphic abstractDiagram of beta-cell dysfunction in different ethnic subjects during T2DM and the risk factors and medications for beta-cell function regulation in Chinese patients
C1 [Chen, Yibing; Jiang, Qian; Xing, Xiaowei; Li, Pingping] Chinese Acad Med Sci & Peking Union Med Coll, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China.
   [Chen, Yibing; Jiang, Qian; Xing, Xiaowei; Li, Pingping] Chinese Acad Med Sci, Diabet Res Ctr, Beijing 100050, Peoples R China.
   [Chen, Yibing; Jiang, Qian; Xing, Xiaowei; Li, Pingping] CAMS Key Lab Mol Mech & Target Discovery Metab Dis, Beijing 100050, Peoples R China.
   [Yuan, Tao] Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Endocrinol, Key Lab Endocrinol Minist Hlth, Beijing 100730, Peoples R China.
C3 Chinese Academy of Medical Sciences - Peking Union Medical College;
   Peking Union Medical College; Chinese Academy of Medical Sciences -
   Peking Union Medical College; Chinese Academy of Medical Sciences -
   Peking Union Medical College; Peking Union Medical College; Peking Union
   Medical College Hospital
RP Li, PP (corresponding author), Chinese Acad Med Sci & Peking Union Med Coll, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China.; Li, PP (corresponding author), Chinese Acad Med Sci, Diabet Res Ctr, Beijing 100050, Peoples R China.; Li, PP (corresponding author), CAMS Key Lab Mol Mech & Target Discovery Metab Dis, Beijing 100050, Peoples R China.; Yuan, T (corresponding author), Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Endocrinol, Key Lab Endocrinol Minist Hlth, Beijing 100730, Peoples R China.
EM t75y@sina.com; lipp@imm.ac.cn
RI Li, pingping/JPW-9278-2023; Chen, Yibing/MIN-8134-2025
FU National Natural Science Foundation of China [82473984]; CAMS Innovation
   Fund for Medical Sciences [2021-I2M-1-026]; Beijing Outstanding Young
   Scientist Program [BJJWZYJH01201910023028]
FX This study was supported by the National Natural Science Foundation of
   China (82473984, China), the CAMS Innovation Fund for Medical Sciences
   (2021-I2M-1-026, China) and the Beijing Outstanding Young Scientist
   Program (BJJWZYJH01201910023028, China).
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NR 200
TC 3
Z9 3
U1 20
U2 31
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1389-9155
EI 1573-2606
J9 REV ENDOCR METAB DIS
JI Rev. Endocr. Metab. Disord.
PD FEB
PY 2025
VL 26
IS 1
BP 31
EP 53
DI 10.1007/s11154-024-09914-9
EA OCT 2024
PG 23
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA U5S1I
UT WOS:001329071600001
PM 39382753
DA 2025-06-11
ER

PT J
AU Huang, JK
   Lee, HC
AF Jih-Kai Huang
   Hsiang-Chun Lee
TI Emerging Evidence of Pathological Roles of Very-Low-Density Lipoprotein
   (VLDL)
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE very-low-density lipoprotein (VLDL); VLDL receptor (VLDLR); metabolic
   syndrome (MetS); insulin resistance; metabolic associated fatty liver
   disease (MAFLD); endocrinological disorders; cardiovascular disorders;
   cognitive dysfunction; cancer; atrial myopathy
ID FATTY LIVER-DISEASE; HEPATITIS-C VIRUS; TRIGLYCERIDE-RICH LIPOPROTEINS;
   ATHEROSCLEROTIC CARDIOVASCULAR-DISEASE; APOLIPOPROTEIN-E RECEPTOR; LIPID
   PROFILE; INSULIN-RESISTANCE; OXIDATIVE STRESS; APOC-III; SUBCLINICAL
   HYPOTHYROIDISM
AB Embraced with apolipoproteins (Apo) B and Apo E, triglyceride-enriched very-low-density lipoprotein (VLDL) is secreted by the liver into circulation, mainly during post-meal hours. Here, we present a brief review of the physiological role of VLDL and a systemic review of the emerging evidence supporting its pathological roles. VLDL promotes atherosclerosis in metabolic syndrome (MetS). VLDL isolated from subjects with MetS exhibits cytotoxicity to atrial myocytes, induces atrial myopathy, and promotes vulnerability to atrial fibrillation. VLDL levels are affected by a number of endocrinological disorders and can be increased by therapeutic supplementation with cortisol, growth hormone, progesterone, and estrogen. VLDL promotes aldosterone secretion, which contributes to hypertension. VLDL induces neuroinflammation, leading to cognitive dysfunction. VLDL levels are also correlated with chronic kidney disease, autoimmune disorders, and some dermatological diseases. The extra-hepatic secretion of VLDL derived from intestinal dysbiosis is suggested to be harmful. Emerging evidence suggests disturbed VLDL metabolism in sleep disorders and in cancer development and progression. In addition to VLDL, the VLDL receptor (VLDLR) may affect both VLDL metabolism and carcinogenesis. Overall, emerging evidence supports the pathological roles of VLDL in multi-organ diseases. To better understand the fundamental mechanisms of how VLDL promotes disease development, elucidation of the quality control of VLDL and of the regulation and signaling of VLDLR should be indispensable. With this, successful VLDL-targeted therapies can be discovered in the future.
C1 [Jih-Kai Huang] Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Gen Med, Kaohsiung 80708, Taiwan.
   [Hsiang-Chun Lee] Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Internal Med, Div Cardiol, Kaohsiung 80708, Taiwan.
   [Hsiang-Chun Lee] Kaohsiung Med Univ, Coll Med, Sch Med, Dept Internal Med, Kaohsiung 80708, Taiwan.
   [Hsiang-Chun Lee] Kaohsiung Med Univ, Coll Med, Lipid Sci & Aging Res Ctr, Kaohsiung 80708, Taiwan.
   [Hsiang-Chun Lee] Natl Sun Yat Sen Univ, Inst Med Sci & Technol, Kaohsiung 80708, Taiwan.
   [Hsiang-Chun Lee] Natl Pingtung Univ Sci & Technol, Grad Inst Anim Vaccine Technol, Pingtung 91201, Taiwan.
C3 Kaohsiung Medical University; Kaohsiung Medical University Hospital;
   Kaohsiung Medical University; Kaohsiung Medical University Hospital;
   Kaohsiung Medical University; Kaohsiung Medical University; National Sun
   Yat Sen University; National Pingtung University Science & Technology
RP Lee, HC (corresponding author), Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Internal Med, Div Cardiol, Kaohsiung 80708, Taiwan.; Lee, HC (corresponding author), Kaohsiung Med Univ, Coll Med, Sch Med, Dept Internal Med, Kaohsiung 80708, Taiwan.; Lee, HC (corresponding author), Kaohsiung Med Univ, Coll Med, Lipid Sci & Aging Res Ctr, Kaohsiung 80708, Taiwan.; Lee, HC (corresponding author), Natl Sun Yat Sen Univ, Inst Med Sci & Technol, Kaohsiung 80708, Taiwan.; Lee, HC (corresponding author), Natl Pingtung Univ Sci & Technol, Grad Inst Anim Vaccine Technol, Pingtung 91201, Taiwan.
EM eric86425@gmail.com; hclee@kmu.edu.tw
OI Huang, Jih-Kai/0000-0002-8837-0377; Lee, Hsiang-Chun/0000-0002-5877-9059
FU Kaohsiung Medical University Hospital [KMUH97-7G31, KMUH103-3T03,
   KMUH104-4T04, KMUH107-7R11, KMUH108-8R10]; Kaohsiung Medical University
   [KMU-TP104D04]; Taiwan Ministry of Science and Technology [MOST
   10314-B-037080-MY3]; NSYSU-KMU Joint Research Project [NSYSUKMU
   104-P027]; KMU Global Networking Talent Plan [110KMUOR01]
FX This research was funded by Kaohsiung Medical University Hospital
   (KMUH97-7G31, KMUH103-3T03, KMUH104-4T04, KMUH107-7R11, and
   KMUH108-8R10), Kaohsiung Medical University (KMU-TP104D04), Taiwan
   Ministry of Science and Technology grants (MOST 10314-B-037080-MY3), the
   NSYSU-KMU Joint Research Project (#NSYSUKMU 104-P027), and the KMU
   Global Networking Talent Plan (110KMUOR01).
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NR 240
TC 49
Z9 55
U1 4
U2 31
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD APR
PY 2022
VL 23
IS 8
AR 4300
DI 10.3390/ijms23084300
PG 21
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 0R2LL
UT WOS:000785433300001
PM 35457118
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Eleazu, C
   Omar, N
   Lim, OZ
   Yeoh, BS
   Hussain, NHN
   Mohamed, M
AF Eleazu, Chinedum
   Omar, Norsuhana
   Lim, Oon Zhi
   Yeoh, Boon Seng
   Hussain, Nik Hazlina Nik
   Mohamed, Mahaneem
TI Obesity and Comorbidity: Could Simultaneous Targeting of esRAGE and
   sRAGE Be the Panacea?
SO FRONTIERS IN PHYSIOLOGY
LA English
DT Review
DE obesity; nutrition; metabolic dysregulation; receptor for advanced
   glycation end products; metabolic syndrome
ID GLYCATION END-PRODUCTS; ENDOGENOUS SECRETORY RAGE; SOLUBLE RECEPTOR;
   WEIGHT-LOSS; METABOLIC SYNDROME; OXIDANT STRESS; ASSOCIATION;
   ENDPRODUCTS; MANAGEMENT; BIOMARKER
AB Obesity, a chronic multifaceted disease, predisposes its patients to increased risk of metabolic disorders such as: diabetes mellitus, cardiovascular diseases, dyslipidemia, etc. Recent studies reported it to be amongst the leading causes of deaths in the world. Although several treatment options for obesity abound, many of them have not been able to successfully reverse the existing obesity and metabolic dysregulation. This has therefore warranted the need for either alternative therapies or diversification of the treatment approach for obesity and its comorbidity. When the receptor for advanced glycation end products (RAGE) interacts with its ligand, RAGE-ligand activates an inflammatory signaling cascade, that leads to the activation of nuclear factor kappa B (NF-kappa B) and transcription of inflammatory cytokines. This action has been associated with the development of obesity and its mediated metabolic dysregulation. In view of the increasing prevalence of obesity globally and the potential threat it places on life expectancy, this article reviewed the promising potentials of targeting endogenous secretory receptor for advanced glycation end products/soluble receptors for advanced glycation end products signaling as a treatment approach for obesity. We carried out a literature search in several electronic data bases such as: Pubmed, Pubmed Central, Google, Google Scholar, Scopus, and Medline from 1980 to 2019 to acquire the status of information concerning this. The article suggests the need for the development of an esRAGE/sRAGE targeted pharmacotherapy as a treatment approach for obesity and its comorbidity.
C1 [Eleazu, Chinedum; Omar, Norsuhana; Lim, Oon Zhi; Yeoh, Boon Seng; Mohamed, Mahaneem] Univ Sains Malaysia, Sch Med Sci, Dept Physiol, Kubang Kerian, Malaysia.
   [Eleazu, Chinedum] Alex Ekwueme Fed Univ, Dept Chem Biochem Mol Biol, Ndufu Alike, Ikwo, Nigeria.
   [Hussain, Nik Hazlina Nik] Univ Sains Malaysia, Womens Hlth Dev Unit, Kubang Kerian, Malaysia.
C3 Universiti Sains Malaysia; Universiti Sains Malaysia
RP Mohamed, M (corresponding author), Univ Sains Malaysia, Sch Med Sci, Dept Physiol, Kubang Kerian, Malaysia.
EM mahaneem@usm.my
RI Eleazu, Chinedum/AAY-8306-2020; Mohamed, Mahaneem/F-1159-2011; Lim,
   Oon/Y-9658-2018; Nik Hussain, Nik Hazlina/G-5453-2015
OI Eleazu, Chinedum/0000-0002-1574-0445; Nik Hussain, Nik
   Hazlina/0000-0002-9476-062X; Yeoh, Boon Seng/0000-0002-5766-2270
FU Universiti Sains Malaysia
FX CE is grateful to the Universiti Sains Malaysia for granting him a
   postdoctoral fellowship.
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NR 74
TC 20
Z9 20
U1 0
U2 4
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-042X
J9 FRONT PHYSIOL
JI Front. Physiol.
PD JUN 25
PY 2019
VL 10
AR 787
DI 10.3389/fphys.2019.00787
PG 13
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA IF6RO
UT WOS:000473208000001
PM 31293451
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Mossa, A
   Flores, MV
   Nguyen, H
   Cammisotto, PG
   Campeau, L
AF Mossa, Abubakr
   Flores, Monica Velasquez
   Nguyen, Hieu
   Cammisotto, Philippe G.
   Campeau, Lysanne
TI Beta-3 Adrenoceptor Signaling Pathways in Urothelial and Smooth Muscle
   Cells in the Presence of Succinate
SO JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
LA English
DT Article
ID ACTIVATED PROTEIN-KINASE; NITRIC-OXIDE SYNTHASE; URINARY-TRACT SYMPTOMS;
   METABOLIC SYNDROME; ADENYLATE-CYCLASE; IN-VITRO; PHARMACOLOGICAL
   PROFILE; ADRENERGIC-RECEPTORS; EXPRESSION; BLADDER
AB Succinate, an intermediate metabolite of the Krebs cycle, can alter the metabolomics response to certain drugs and controls an array of molecular responses in the urothelium through activation of its receptor, G-protein coupled receptor 91 (GPR91). Mirabegron, a beta 3-adrenergic receptor (beta 3-AR) agonist used to treat overactive bladder syndrome (OAB), increases intracellular cAMP in the detrusor smooth muscle cells (SMC), leading to relaxation. We have previously shown that succinate inhibits forskolin-stimulated cAMP production in urothelium. To determine whether succinate interferes with mirabegron-mediated bladder relaxation, we examined their individual and synergistic effect in urothelial-cell and SMC signaling. We first confirmed beta 3-AR involvement in the mirabegron response by quantifying receptor abundance by immunoblotting in cultured urothelial cells and SMC and cellular localization by immunohistochemistry in rat bladder tissue. Mirabegron increased cAMP levels in SMC but not in urothelial cells, an increase that was inhibited by succinate, suggesting that it impairs cAMP-mediated bladder relaxation by mirabegron. Succinate and mirabegron increased inducible nitric oxide synthesis and nitric oxide secretion only in urothelial cells, suggesting that its release can indirectly induces SMC relaxation. Succinate exposure decreased the expression of beta 3-AR protein in whole bladder in vivo and in SMC in vitro, indicating that this metabolite may lead to impaired pharmacodynamics of the bladder. Together, our results demonstrate that increased levels of succinate in settings of metabolic stress (e.g., the metabolic syndrome) may lead to impaired mirabegron and beta 3-AR interaction, inhibition of cAMP production, and ultimately requiring mirabegron dose adjustment for its treatment of OAB related to these conditions.
C1 [Mossa, Abubakr; Flores, Monica Velasquez; Nguyen, Hieu; Cammisotto, Philippe G.; Campeau, Lysanne] McGill Univ, Lady Davis Res Inst, 3755 Chemin Cote Ste Catherine, Montreal, PQ H3T 1E2, Canada.
C3 McGill University
RP Campeau, L (corresponding author), McGill Univ, Lady Davis Res Inst, 3755 Chemin Cote Ste Catherine, Montreal, PQ H3T 1E2, Canada.
EM lysanne.campeau@mcgill.ca
RI Mossa, Abubakr/GRN-8072-2022; Cammisotto, Philippe/GSD-6497-2022
OI Mossa, Abubakr/0000-0002-9101-113X
FU Canadian Urological Association Foundation CUA Astellas Research Grant
FX This research was supported by a Canadian Urological Association
   Foundation CUA Astellas Research Grant.
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NR 56
TC 11
Z9 15
U1 0
U2 6
PU AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3995 USA
SN 0022-3565
EI 1521-0103
J9 J PHARMACOL EXP THER
JI J. Pharmacol. Exp. Ther.
PD NOV 1
PY 2018
VL 367
IS 2
BP 252
EP 259
DI 10.1124/jpet.118.249979
PG 8
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA HB3TJ
UT WOS:000450973800007
PM 30104323
OA Bronze
DA 2025-06-11
ER

PT J
AU Frank, N
   Tadros, EM
AF Frank, N.
   Tadros, E. M.
TI Insulin dysregulation
SO EQUINE VETERINARY JOURNAL
LA English
DT Review
DE horse; insulin; glucose; insulin dysregulation; insulin resistance;
   laminitis; diabetes
ID PARS-INTERMEDIA DYSFUNCTION; C-PEPTIDE CONCENTRATIONS; GESTATIONAL-AGE
   INFANTS; GLUCAGON-LIKE PEPTIDE-1; CRITICALLY-ILL FOALS; FATTY
   LIVER-DISEASE; ADIPOSE-TISSUE; DIABETES-MELLITUS; ENDOTHELIAL
   DYSFUNCTION; LIPID-METABOLISM
AB Abnormalities of insulin metabolism include hyperinsulinaemia and insulin resistance, and these problems are collectively referred to as insulin dysregulation in this review. Insulin dysregulation is a key component of equine metabolic syndrome: a collection of endocrine and metabolic abnormalities associated with the development of laminitis in horses, ponies and donkeys. Insulin dysregulation can also accompany prematurity and systemic illness in foals. Causes of insulin resistance are discussed, including pathological conditions of obesity, systemic inflammation and pituitary pars intermedia dysfunction, as well as the physiological responses to stress and pregnancy. Most of the discussion of insulin dysregulation to date has focused on insulin resistance, but there is increasing interest in hyperinsulinaemia itself and insulin responses to feeding. An oral sugar test or in-feed oral glucose tolerance test can be performed to assess insulin responses to dietary carbohydrates, and these tests are now recommended for use in clinical practice. Incretin hormones are likely to play an important role in postprandial hyperinsulinaemia and are the subject of current research. Insulin resistance exacerbates hyperinsulinaemia, and insulin sensitivity can be measured by performing a combined glucose-insulin test or i.v. insulin tolerance test. In both of these tests, exogenous insulin is administered and the rate of glucose uptake into tissues measured. Diagnosis and management of hyperinsulinaemia is recommended to reduce the risk of laminitis. The term insulin dysregulation is introduced here to refer collectively to excessive insulin responses to sugars, fasting hyperinsulinaemia and insulin resistance, which are all components of equine metabolic syndrome.
C1 [Frank, N.] Tufts Cummings Sch Vet Med, Dept Clin Sci, North Grafton, MA USA.
   [Frank, N.] Univ Nottingham, Sch Vet Med & Sci, Div Vet Med, Loughborough, Leics, England.
   [Tadros, E. M.] Michigan State Univ, Coll Vet Med, Dept Large Anim Clin Sci, E Lansing, MI 48824 USA.
C3 University of Nottingham; Michigan State University
RP Frank, N (corresponding author), Tufts Cummings Sch Vet Med, Dept Clin Sci, North Grafton, MA USA.
EM nicholas.frank@tufts.edu
FU Boehringer Ingelheim Vetmedica
FX Dr Frank has received research funding in the past from Boehringer
   Ingelheim Vetmedica.
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NR 172
TC 173
Z9 195
U1 2
U2 103
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0425-1644
EI 2042-3306
J9 EQUINE VET J
JI Equine Vet. J.
PD JAN
PY 2014
VL 46
IS 1
BP 103
EP 112
DI 10.1111/evj.12169
PG 10
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA 267HJ
UT WOS:000328087800022
PM 24033478
OA Bronze
DA 2025-06-11
ER

PT J
AU Sasaki, Y
   Shimada, T
   Iizuka, S
   Suzuki, W
   Makihara, H
   Teraoka, R
   Tsuneyama, K
   Hokao, R
   Aburada, M
AF Sasaki, Yoshiyuki
   Shimada, Tsutomu
   Iizuka, Seiichi
   Suzuki, Wataru
   Makihara, Hiroko
   Teraoka, Ryutaro
   Tsuneyama, Koichi
   Hokao, Ryoji
   Aburada, Masaki
TI Effects of bezafibrate in nonalcoholic steatohepatitis model mice with
   monosodium glutamate-induced metabolic syndrome
SO EUROPEAN JOURNAL OF PHARMACOLOGY
LA English
DT Article
DE Obesity; Diabetes mellitus; Metabolic syndrome; Nonalcoholic fatty liver
   disease
ID FATTY LIVER-DISEASE; RESISTANCE-ASSOCIATED PROTEIN-2; BROWN
   ADIPOSE-TISSUE; OXIDATIVE STRESS; ANIMAL-MODELS; RECEPTOR; EXPRESSION;
   ADIPOCYTOKINES; ADIPONECTIN; DIAGNOSIS
AB Recently, we reported that monosodium glutamate-treated mice (MSG mice) developed severe hyperlipidemia and diabetes mellitus and several complications of obesity. MSG mice acquired fatty livers and subsequently underwent changes that are characteristic of nonalcoholic fatty liver disease (NAFLD)/nonalcoholic steatohepatitis (NASH). In the present study, the effects of bezafibrate on obesity, diabetes mellitus. and NAFLD/NASH were examined in MSG mice. A single dose of MSG (4 mg/g) was administered subcutaneously to neonatal male mice within 24 h of birth. Bezafibrate was mixed into the normal feed for 8 weeks. The weight and body mass index of MSG mice increased significantly despite the unchanged intake of food. Triglyceride and total cholesterol levels in blood, visceral adipose tissue, and interscapular adipose tissue rose significantly. In the livers of MSG mice, moderate centrilobular microvesicular steatosis, ballooning degeneration with Mallory bodies, and scattered infiltration of neutrophils and lymphocytes were observed. Centrilobular hepatocytes were 4-hydroxynonenal-positive in MSG mice. Bezafibrate ameliorated the severity of diabetes mellitus, hyperinsulinemia, and hyperlipidemia. Adiponectin and leptin concentrations in blood improved, and the accumulation of visceral fat was inhibited. The expression of acyl-CoA oxidase, a beta-oxidation gene, and carnitine palmitoyl transferase, which regulates lipid metabolism, increased markedly on administration of bezafibrate. The liver pathology in MSG mice also improved with bezafibrate; specifically, macro- and microvesicles in hepatocytes nearly disappeared, and NAFLD activity score improved. It is concluded that bezafibrate inhibits the accumulation of visceral fat, following amelioration of hyperlipidemia, in MSG-induced obese mice, due to improvements in diabetes mellitus, fatty liver, and NAFLD. (C) 2011 Elsevier B.V. All rights reserved.
C1 [Sasaki, Yoshiyuki; Shimada, Tsutomu; Iizuka, Seiichi; Suzuki, Wataru; Aburada, Masaki] Musashino Univ, Pharmaceut Sci Res Inst, Nishitokyo, Tokyo 2028585, Japan.
   [Sasaki, Yoshiyuki; Hokao, Ryoji] Inst Anim Reprod, Kasumigaura, Ibaraki 3000134, Japan.
   [Makihara, Hiroko; Teraoka, Ryutaro] Musashino Univ, Grad Sch Pharmaceut Sci, Nishitokyo, Tokyo 2028585, Japan.
   [Tsuneyama, Koichi] Toyama Univ, Dept Diagnost Pathol, Grad Sch Med & Pharmaceut Sci, Toyama 9300194, Japan.
C3 University of Toyama
RP Aburada, M (corresponding author), Musashino Univ, Pharmaceut Sci Res Inst, 1-1-20 Shinmachi, Nishitokyo, Tokyo 2028585, Japan.
EM aburada@musashino-u.ac.jp
OI Tsuneyama, Koichi/0000-0002-0670-9868
FU MEXT (Ministry of Education Culture, Sports, Science and Technology,
   Japan; Grants-in-Aid for Scientific Research [21590433] Funding Source:
   KAKEN
FX This work was supported in part by the 'High-Tech Research Center'
   project for private universities with a matching fund subsidy from MEXT
   (Ministry of Education Culture, Sports, Science and Technology,
   2004-2008), Japan.
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NR 38
TC 36
Z9 37
U1 0
U2 11
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0014-2999
J9 EUR J PHARMACOL
JI Eur. J. Pharmacol.
PD JUL 15
PY 2011
VL 662
IS 1-3
BP 1
EP 8
DI 10.1016/j.ejphar.2011.04.051
PG 8
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 776YM
UT WOS:000291577200001
PM 21549692
DA 2025-06-11
ER

PT J
AU Rosenson, RS
   Vracar-Grabar, M
   Helenowski, I
AF Rosenson, Robert S.
   Vracar-Grabar, Marina
   Helenowski, Irene
TI Lipoprotein associated phospholipase A2 inhibition reduces
   generation of oxidized fatty acids
SO CARDIOVASCULAR DRUGS AND THERAPY
LA English
DT Article
DE lipoprotein associated phospholipase A(2); oxidative stress;
   inflammation; lipoproteins
ID ACTIVATING-FACTOR ACETYLHYDROLASE; EXPRESSION; RISK
AB Purpose Lipoprotein associated phospholipase A(2) (Lp-PLA(2)) is an emerging cardiovascular risk marker. After low-density lipoprotein (LDL) oxidation, Lp-PLA(2) generates oxidized nonesterified fatty acids and lysophosphatidylcholine, both of which have demonstrated proinflammatory and proapoptotic activities. Through the use of a selective inhibitor of Lp-PLA(2) (SB-677116), we investigated whether Lp-PLA(2) participates in the ex vivo generation of oxidized fatty acids (ox-FA).
   Methods Due to the higher correlation between Lp-PLA(2) activity and small LDL particles, we investigated the effects of a selective Lp-PLA(2) inhibition on production of ox-FA in metabolic syndrome subjects with small LDL size < 20.5 nm. Whole blood samples were incubated with vehicle (0 mu M) or SB-677116 for 6 h at two different concentrations (0.3, 3.0 mu M) to determine the effects of inhibitor on Lp-PLA(2) activity, the formation of oxidized esterified and nonesterified hydroxy-fatty acid (OH-FA) or ox-FA in 24 subjects.
   Results Whole blood incubation with Lp-PLA(2) inhibitor (0.3, 3.0 mu M) reduced multiple C-18 OH-FA subclasses (p<0.05 versus control). For the highly redox-sensitive 9-OH-FA, there was a concentration-dependent reduction in Lp-PLA(2) activity and 9-OH-FA (p(trend) = 0.0016)
   Conclusions In conclusion, selective inhibition of Lp-PLA(2) reduced levels of OH-FA generated in whole blood of metabolic syndrome patients. These novel findings suggest that Lp-PLA(2) inhibition may attenuate some noxious downstream effects of lipid peroxidation that potentially include inflammatory responses.
C1 [Rosenson, Robert S.] Univ Michigan, Sch Med, Dept Internal Med, Div Cardiovasc Med, Ann Arbor, MI USA.
   [Vracar-Grabar, Marina] Northwestern Univ, Dept Med, Chicago, IL 60611 USA.
   [Helenowski, Irene] Northwestern Univ, Dept Prevent Med, Chicago, IL 60611 USA.
C3 University of Michigan System; University of Michigan; Northwestern
   University; Northwestern University
RP Rosenson, RS (corresponding author), Univ Michigan, Sch Med, Dept Internal Med, Div Cardiovasc Med, Ann Arbor, MI USA.
EM rrosenso@umich.edu
RI Rosenson, Robert/MDS-6957-2025
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NR 14
TC 13
Z9 20
U1 0
U2 2
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0920-3206
EI 1573-7241
J9 CARDIOVASC DRUG THER
JI Cardiovasc. Drugs Ther.
PD FEB
PY 2008
VL 22
IS 1
BP 55
EP 58
DI 10.1007/s10557-008-6080-4
PG 4
WC Cardiac & Cardiovascular Systems; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Pharmacology & Pharmacy
GA 262EV
UT WOS:000253132700007
PM 18214661
DA 2025-06-11
ER

PT J
AU Moreno, PR
   Fuster, V
AF Moreno, PR
   Fuster, V
TI New aspects in the pathogenesis of diabetic atherothrombosis
SO JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
LA English
DT Article
ID ENDOTHELIAL GROWTH-FACTOR; HUMAN ATHEROSCLEROTIC LESIONS; LIFE-STYLE
   INTERVENTION; CORONARY-HEART-DISEASE; TISSUE FACTOR; METABOLIC SYNDROME;
   HIGH-RESOLUTION; PLAQUE NEOVASCULARIZATION; ADVENTITIAL INFLAMMATION;
   ATHERECTOMY SPECIMENS
AB Diabetes mellitus is increasing worldwide, resulting from the interaction of obesity, inflammation, and hyperglycemia. Activated immunity and cytokine production lead to insulin resistance and other components of the metabolic syndrome, establishing the link between diabetes and atherosclerosis. Hyperglycemia-induced endothelial dysfunction is mediated by increased oxidative stress, a promoter of adventitial inflammation and vasa vasorum neovascularization in experimental models of diabetic atherosclerosis. Recent studies have documented increased inflammation, neovascularization, and intraplaque hemorrhage in human diabetic atherosclerosis. This inflammatory microangiopathic process is independently associated with plaque rupture, leading to coronary thrombosis. Tissue factor, the most potent trigger of the coagulation cascade, is increased in diabetic patients with poor glycemic control. Circulating tissue factor microparticles are also associated with apoptosis of plaque macrophages, closing the link among inflammation, plaque rupture, and blood thrombogenicity. High-density lipoproteins, responsible for free cholesterol removal, are reduced in patients with insulin resistance and diabetes. High-density lipoprotein therapy leads to a significant decrease in plaque macrophages and increase in smooth-muscle cells. These beneficial effects may be responsible for coronary plaque stabilization in patients treated with recombinant Apolipoprotein A-I Milano/phospholipid complex. Finally, peroxisomal proliferator-activated receptors (PPARs) are now considered the nuclear transcriptional regulators of atherosclerosis. Three subfamilies, including PPAR-alpha, -delta, and -gamma, have been identified with crucial roles in lipid metabolism, plaque inflammation, expression of adhesion molecules and cytokines, and regulation of matrix metalloproteinases. Multiple experimental studies have documented plaque stabilization with PPAR-gamma agonists, a group of medications holding great promise in the treatment of diabetes atherosclerosis. (C) 2004 by the American College of Cardiology Foundation.
C1 CUNY Mt Sinai Sch Med, Zena & Michael Wiener Cardiovasc Inst, New York, NY 10029 USA.
   Univ Kentucky, Gill Heart Inst, Lexington, KY 40506 USA.
C3 City University of New York (CUNY) System; Icahn School of Medicine at
   Mount Sinai; University of Kentucky
RP CUNY Mt Sinai Sch Med, Cardiovasc Inst, POB 1030,1 Gustave L Levy Pl, New York, NY 10029 USA.
EM Pedro.Moreno@msnyuhealth.org
RI Fuster, Valentin/H-4319-2015
OI Fuster, Valentin/0000-0002-9043-9986
FU NHLBI NIH HHS [HL 54469, HL 61801] Funding Source: Medline
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NR 69
TC 268
Z9 296
U1 1
U2 14
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0735-1097
EI 1558-3597
J9 J AM COLL CARDIOL
JI J. Am. Coll. Cardiol.
PD DEC 21
PY 2004
VL 44
IS 12
BP 2293
EP 2300
DI 10.1016/j.jacc.2004.07.060
PG 8
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 882GE
UT WOS:000225926400002
PM 15607389
DA 2025-06-11
ER

PT J
AU Shen, LH
   Yang, Y
   Zhang, JL
   Feng, LJ
   Zhou, Q
AF Shen, Luhong
   Yang, Yang
   Zhang, Jiuliang
   Feng, Lanjie
   Zhou, Qing
TI Diacylated anthocyanins from purple sweet potato (Ipomoea batatas
   L.) attenuate hyperglycemia and hyperuricemia in mice induced by a
   high-fructose/high-fat diet
SO JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
LA English
DT Article
DE Diacylated anthocyanins from purple sweet potato (diacylated AF-PSPs);
   Hyperglycemia; Hyperuricemia; Metabolism syndrome; Regulation of renal
   function
ID CHRONIC KIDNEY-DISEASE; URIC-ACID LEVEL; METABOLIC SYNDROME;
   INFLAMMATION; POLYPHENOLS; ACTIVATION; QUERCETIN
AB Studies have shown that targeting xanthine oxidase (XO) can be a feasible treatment for fructose-induced hyperuricemia and hyperglycemia. This study aimed to evaluate the dual regulatory effects and molecular mechanisms of diacylated anthocyanins from purple sweet potato (diacylated AF-PSPs) on hyperglycemia and hyperuricemia induced by a high-fructose/high-fat diet. The body weight, organ index, serum biochemical indexes, and liver antioxidant indexes of mice were measured, and the kidneys were observed in pathological sections. The relative expression levels of messenger RNAs (mRNAs) of fructose metabolism pathway enzymes in kidney were detected by fluorescent real-time quantitative polymerase chain (qPCR) reaction technique, and the expression of renal transporter protein and inflammatory factor pathway protein was determined by immunohistochemistry (IHC) technique. Results showed that diacylated AF-PSPs alleviated hyperuricemia in mice, and that this effect might be related to the regulation of liver XO activity, lipid accumulation, and relevant renal transporters. Diacylated AF-PSPs reduced body weight and relieved lipid metabolism disorder, liver lipid accumulation, and liver oxidative stress, thereby enhancing insulin utilization and sensitivity, lowering blood sugar, and reducing hyperglycemia in mice. Also, diacylated AF-PSPs restored mRNA levels related to renal fructose metabolism, and reduced kidney injury and inflammation. This study provided experimental evidence for the mechanisms of dual regulation of blood glucose and uric acid (UA) by diacylated AF-PSPs and their utilization as functional foods in the management of metabolic syndrome.
C1 [Shen, Luhong; Yang, Yang; Zhang, Jiuliang; Feng, Lanjie] Huazhong Agr Univ, Coll Food Sci & Technol, Wuhan 430070, Peoples R China.
   [Zhou, Qing] Huazhong Univ Sci & Technol, Wuhan City Cent Hosp, Tongji Med Coll, Dept Pharm, Wuhan 430014, Peoples R China.
C3 Huazhong Agricultural University; Huazhong University of Science &
   Technology
RP Zhang, JL (corresponding author), Huazhong Agr Univ, Coll Food Sci & Technol, Wuhan 430070, Peoples R China.; Zhou, Q (corresponding author), Huazhong Univ Sci & Technol, Wuhan City Cent Hosp, Tongji Med Coll, Dept Pharm, Wuhan 430014, Peoples R China.
EM zjl_ljz@mail.hzau.edu.cn; qingz_zqing@aliyun.com
RI Yang, Yuyi/N-5428-2015; , Jiuliang/ADF-2357-2022
OI , Jiuliang/0000-0002-1745-846X; Yang, Yang/0000-0001-5506-9396
FU National Key Technologies R&D Program of China [2021YFE0194000];
   Fundamental Research Funds for the Central Universities of China
   [2662018PY022]
FX AcknowledgmentsThis work was supported by the National Key Technologies
   R&D Program of China (No. 2021YFE0194000) and the Fundamental Research
   Funds for the Central Universities of China (No. 2662018PY022).
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NR 33
TC 6
Z9 6
U1 10
U2 50
PU ZHEJIANG UNIV PRESS
PI Hangzhou
PA Xixi Campus, Zhejiang University, No. 148 Tianmushan Road, Hangzhou,
   Zhejiang, PEOPLES R CHINA
SN 1673-1581
EI 1862-1783
J9 J ZHEJIANG UNIV-SC B
JI J. Zhejiang Univ.-SCI. B
PD JUL
PY 2023
VL 24
IS 7
SI SI
BP 587
EP 601
DI 10.1631/jzus.B2200587
EA APR 2023
PG 15
WC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
   Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
   Research & Experimental Medicine
GA N4PY7
UT WOS:000970003800001
PM 37455136
OA Green Published
DA 2025-06-11
ER

PT J
AU Rivera, DS
   Lindsay, CB
   Codocedo, JF
   Carreño, LE
   Cabrera, D
   Arrese, MA
   Vio, CP
   Bozinovic, F
   Inestrosa, NC
AF Rivera, Daniela S.
   Lindsay, Carolina B.
   Codocedo, Juan F.
   Carreno, Laura E.
   Cabrera, Daniel
   Arrese, Marco A.
   Vio, Carlos P.
   Bozinovic, Francisco
   Inestrosa, Nibaldo C.
TI Long-Term, Fructose-Induced Metabolic Syndrome-Like Condition Is
   Associated with Higher Metabolism, Reduced Synaptic Plasticity and
   Cognitive Impairment in Octodon degus
SO MOLECULAR NEUROBIOLOGY
LA English
DT Article
DE Octodon degus; Fructose; Insulin resistance; Basal metabolic rate;
   Non-alcoholic fatty liver; Behaviour performance; Synaptic plasticity
ID NONALCOHOLIC FATTY LIVER; SUGAR RICH DIET; INSULIN-RESISTANCE;
   ALZHEIMERS-DISEASE; DIABETES-MELLITUS; OXIDATIVE STRESS; NATURAL MODEL;
   SWEETENED BEVERAGES; ENERGY HOMEOSTASIS; SOCIAL RECOGNITION
AB There has been a progressive increase in the incidence of fructose-induced metabolic disorders, such as metabolic syndrome (MetS). Moreover, novel evidence reported negative effects of high-fructose diets in brain function. This study was designed to evaluate for the first time the effects of long-term fructose consumption (LT-FC) on the normal ageing process in a long-lived animal model rodent, Octodon degus or degu. Moreover, we could replicate human sugar consumption behaviour over time, leading us to understand then the possible mechanisms by which this MetS-like condition could affect cognitive abilities. Our results support that 28months (from pup to adulthood) of a 15% solution of fructose induced clinical conditions similar to MetS which includes an insulin-resistance scenario together with elevated basal metabolic rate and non-alcoholic fatty liver disease. Additionally, we extended our analysis to evaluate the impact of this MetS-like condition on the functional and cognitive brain processes. Behavioural test suggests that fructose-induced MetS-like condition impair hippocampal-dependent and independent memory performance. Moreover, we also reported several neuropathological events as impaired hippocampal redox balance, together with synaptic protein loss. These changes might be responsible for the alterations in synaptic plasticity and transmitter release observed in these cognitively impaired animals. Our results indicate that LT-FC induced several facets of MetS that eventually could trigger brain disorders, in particular, synaptic dysfunction and reduced cognition.
C1 [Rivera, Daniela S.; Lindsay, Carolina B.; Codocedo, Juan F.; Arrese, Marco A.; Vio, Carlos P.; Inestrosa, Nibaldo C.] Pontificia Univ Catolica Chile, Ctr Envejecimiento & Regenerac CARE, Dept Biol Celular & Mol, Fac Ciencias Biol, Santiago 6513677, Chile.
   [Rivera, Daniela S.; Bozinovic, Francisco] Pontificia Univ Catolica Chile, Dept Ecol, Fac Ciencias Biol, Santiago 6513677, Chile.
   [Rivera, Daniela S.; Bozinovic, Francisco] Pontificia Univ Catolica Chile, Ctr Appl Ecol & Sustainabil CAPES, Fac Ciencias Biol, Santiago 6513677, Chile.
   [Carreno, Laura E.] Univ Chile, Serv Anat Patol, Hosp Clin, Santiago, Chile.
   [Cabrera, Daniel; Arrese, Marco A.] Pontificia Univ Catolica Chile, Dept Gastroenterol, Escuela Med, Fac Med, Santiago, Chile.
   [Cabrera, Daniel] Univ Bernardo OHiggins, Dept Ciencias Quim & Biol, Fac Salud, Santiago, Chile.
   [Vio, Carlos P.; Inestrosa, Nibaldo C.] Univ Magallanes, Ctr Excelencia Biomed Magallanes CEBIMA, Punta Arenas, Chile.
   [Bozinovic, Francisco; Inestrosa, Nibaldo C.] Pontificia Univ Catolica Chile, Ctr UC Sindrome Down, Santiago, Chile.
   [Inestrosa, Nibaldo C.] Univ New South Wales, Ctr Hlth Brain Ageing, Sch Psychiat, Fac Med, Sydney, NSW, Australia.
C3 Pontificia Universidad Catolica de Chile; Pontificia Universidad
   Catolica de Chile; Pontificia Universidad Catolica de Chile; Universidad
   de Chile; Pontificia Universidad Catolica de Chile; Universidad 
   Bernardo O'Higgins; Universidad de Magallanes; Pontificia Universidad
   Catolica de Chile; University of New South Wales Sydney
RP Rivera, DS; Inestrosa, NC (corresponding author), Pontificia Univ Catolica Chile, Ctr Envejecimiento & Regenerac CARE, Dept Biol Celular & Mol, Fac Ciencias Biol, Santiago 6513677, Chile.; Rivera, DS (corresponding author), Pontificia Univ Catolica Chile, Dept Ecol, Fac Ciencias Biol, Santiago 6513677, Chile.; Rivera, DS (corresponding author), Pontificia Univ Catolica Chile, Ctr Appl Ecol & Sustainabil CAPES, Fac Ciencias Biol, Santiago 6513677, Chile.; Inestrosa, NC (corresponding author), Univ Magallanes, Ctr Excelencia Biomed Magallanes CEBIMA, Punta Arenas, Chile.; Inestrosa, NC (corresponding author), Pontificia Univ Catolica Chile, Ctr UC Sindrome Down, Santiago, Chile.; Inestrosa, NC (corresponding author), Univ New South Wales, Ctr Hlth Brain Ageing, Sch Psychiat, Fac Med, Sydney, NSW, Australia.
EM drivera@bio.puc.cl; ninestrosa@bio.puc.cl
RI Lindsay, Carolina/LXW-6683-2024; CABRERA, DANIEL/AAR-5027-2020; Rivera,
   DanielaS/MTF-5052-2025; ARRESE, MARCO/ABB-9061-2021; Vio,
   Carlos/JAX-7281-2023
OI Rivera, Daniela S./0000-0002-1725-423X; Codocedo Henriquez, Juan
   Francisco/0000-0002-9683-2156; Vio, Carlos/0000-0003-1850-5958
FU Fondo Nacional de Desarollo Cientifico y Tecnologico (FONDECYT)
   [3140395]; FONDECYT [1160724, 1150327, 11171001, 11160651]; Basal Centre
   of Excellence in Science and Technology [CONICYT-PFB12/2007, AFB
   170005]; CAPES-CONICYT [FB 0002-2014]
FX This work was supported by a postdoctoral grant from Fondo Nacional de
   Desarollo Cientifico y Tecnologico (FONDECYT) No 3140395 to DSR. PC was
   supported by FONDECYT No 11160651. MAA was supported by FONDECYT No
   1150327. DC was supported by FONDECYT No 11171001. NCI was supported by
   FONDECYT No 1160724 and grants from the Basal Centre of Excellence in
   Science and Technology (CONICYT-PFB12/2007) and AFB 170005. In addition,
   a grant from CAPES-CONICYT FB 0002-2014 (Line 3) was awarded to FB. We
   thank G. Cavieres for assistance with Basal metabolic rate records, C.
   Cespedes for assistance with blood pressure measurements and J. Rios for
   assistance with liver histopathology analysis.
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NR 95
TC 18
Z9 19
U1 0
U2 27
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0893-7648
EI 1559-1182
J9 MOL NEUROBIOL
JI Mol. Neurobiol.
PD DEC
PY 2018
VL 55
IS 12
BP 9169
EP 9187
DI 10.1007/s12035-018-0969-0
PG 19
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA GY3VF
UT WOS:000448483400029
PM 29654490
DA 2025-06-11
ER

PT J
AU Song, YY
   Zhao, MY
   Cheng, X
   Shen, J
   Khound, R
   Zhang, KZ
   Su, QZ
AF Song, Yongyan
   Zhao, Miaoyun
   Cheng, Xiao
   Shen, Jing
   Khound, Rituraj
   Zhang, Kezhong
   Su, Qiaozhu
TI CREBH mediates metabolic inflammation to hepatic VLDL overproduction and
   hyperlipoproteinemia
SO JOURNAL OF MOLECULAR MEDICINE-JMM
LA English
DT Article
DE CREBH; Metabolic inflammation; TNF alpha; VLDL; ApoB; Metabolic syndrome
ID ENDOPLASMIC-RETICULUM STRESS; ACUTE-PHASE RESPONSE; INSULIN-RESISTANCE;
   APOLIPOPROTEIN-B; LIPID-METABOLISM; PROTEIN; EXPRESSION; STEATOSIS;
   RISK; LIPOPROTEINS
AB Metabolic inflammation is closely associated with hyperlipidemia and cardiovascular disease. However, the underlying mechanisms are not fully understood. The current study established that cAMP-responsive-element-binding protein H (CREBH), an acute-phase transcription factor, enhances very-low-density lipoprotein (VLDL) assembly and secretion by upregulating apolipoprotein B (apoB) expression and contributes to metabolic inflammation-associated hyperlipoproteinemia induced by TNF alpha, lipopolysaccharides (LPS), and high-fat diet (HFD) in mice. Specifically, overexpression of CREBH significantly induced mRNA and protein expression of apoB in McA-7777 cells. Luciferase assay further revealed that the presence of CREBH could significantly increase the activity of the apoB gene promoter. In contrast, genetic depletion of CREBH in mice resulted in significant reduction in expression of hepatic apoB mRNA. Challenging mice with an acute fat load led to upregulation of triglyceride (TG)-rich lipoprotein secretion in wild type mice, but not in CREBH-null mice. TNF alpha treatment activated hepatic CREBH expression, which in turn enhanced hepatic apoB biosynthesis and VLDL secretion. Metabolic inflammation induced by LPS or HFD also resulted in overproduction of apoB and hyperlipoproteinemia in wild type mice, but not in CREBH-null mice. This study demonstrates that CREBH could be a mediator between metabolic inflammation and hepatic VLDL overproduction in chronic metabolic disorders. This novel finding establishes CREBH as the first transcription factor that regulates apoB expression on the transcriptional level and the subsequent VLDL biosynthesis in response to metabolic inflammation. The study also provides novel insight into the pathogenesis of hyperlipidemia in metabolic syndrome.
C1 [Song, Yongyan; Zhao, Miaoyun; Cheng, Xiao; Shen, Jing; Khound, Rituraj; Su, Qiaozhu] Univ Nebraska, Dept Nutr & Hlth Sci, 316F Leverton Hall, Lincoln, NE 68583 USA.
   [Zhang, Kezhong] Wayne State Univ, Sch Med, Ctr Mol Med & Genet, Detroit, MI 48201 USA.
C3 University of Nebraska System; University of Nebraska Lincoln; Wayne
   State University
RP Su, QZ (corresponding author), Univ Nebraska, Dept Nutr & Hlth Sci, 316F Leverton Hall, Lincoln, NE 68583 USA.
EM qsu2@unl.edu
RI Khound, Rituraj/IVH-3509-2023; Zhang, Zhiwu/P-6156-2016; Cheng,
   Xiao/AAV-2712-2021
OI Song, Yongyan/0000-0001-6886-0873; Khound, Rituraj/0000-0002-8939-3570;
   Zhang, Kezhong/0000-0002-6062-235X; Su, Qiaozhu/0000-0001-8434-1408
FU NIH [P20 GM104320-01]; Hatch funds from USDA/NIFA; Layman funds from
   UNL; National Institute of Diabetes and Digestive and Kidney Diseases
   [P30DK020572] Funding Source: NIH RePORTER
FX We would like to thank Dr. Randal J. Kaufman (Howard Hughes Medical
   Institute, University of Michigan Medical Center, Ann Arbor, MI, USA)
   for kindly providing the cDNA constructs for pFlag-CREBH-WT and
   pFlag-CREBH-DN. This work was supported by an NIH grant P20 GM104320-01,
   Hatch funds from USDA/NIFA, and Layman funds from UNL to Q. Su.
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NR 34
TC 18
Z9 18
U1 0
U2 7
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0946-2716
EI 1432-1440
J9 J MOL MED
JI J. Mol. Med.
PD AUG
PY 2017
VL 95
IS 8
BP 839
EP 849
DI 10.1007/s00109-017-1534-4
PG 11
WC Genetics & Heredity; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Genetics & Heredity; Research & Experimental Medicine
GA FB1RM
UT WOS:000405921100007
PM 28455595
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Gateva, A
   Assyov, Y
   Velikova, T
   Kamenov, Z
AF Gateva, Antoaneta
   Assyov, Yavor
   Velikova, Tsvetelina
   Kamenov, Zdravko
TI Increased kallistatin levels in patients with obesity and prediabetes
   compared to normal glucose tolerance
SO ENDOCRINE RESEARCH
LA English
DT Article
DE Cardiovascular complications; kallistatin; metabolic syndrome;
   prediabetes
ID ISCHEMIA-REPERFUSION INJURY; CARDIOVASCULAR-DISEASE; INSULIN-RESISTANCE;
   OXIDATIVE STRESS; MICROVASCULAR COMPLICATIONS; TISSUE KALLIKREIN;
   INFLAMMATION; POPULATION; SERPIN; RISK
AB Purpose: Kallistatin is a member of serine protease inhibitors (SERPIN) family, which has various functions such as regulation of cardiovascular function and blood vessels development. Its levels are elevated in patients with type 1 and type 2 diabetes with chronic diabetic complications. The aim of the present study was to compare serum kallistatin levels between obese subjects with prediabetes and with normal glucose tolerance. Methods: In this study we included 80 subjects at mean age of 50.4 +/- 10.6 years, divided into two age and BMI-matched groups - group 1 with obesity without glycemic disturbances (n = 41) and group 2 with obesity and prediabetes (n = 39). Oral glucose tolerance test with measurement of immunoreactive insulin was performed in all participants and levels of kallistatin were measured using ELISA method. Results: We found significantly higher levels of kallistatin in patients with prediabetes compared to controls (data are presented as median (min; max) because data were not normally distributed) (6.3 (4.4; 9.0) vs. 5.6 (3.1; 8.7) ng/ml; p = 0.022) and in patients with metabolic syndrome compared to those without (6.0 (4.9; 9.0) vs. 5.5 (3.1; 7.7); p = 0.006), but the levels were similar in patients with and without insulin resistance. Conclusions: The levels of kallistatin are higher in individuals with prediabetes, but are similar in subjects with and without insulin resistance, which indicates that the main factor for its increased levels may be hyperglycemia and not insulin sensitivity state.
C1 [Gateva, Antoaneta; Assyov, Yavor; Kamenov, Zdravko] Med Univ Sofia, Dept Internal Dis, Univ Hosp Alexandrovska, Clin Endocrinol, Sofia, Bulgaria.
   [Velikova, Tsvetelina] Med Univ Sofia, Dept Clin Lab & Clin Immunol, Univ Hosp St Ivan Rilski, Lab Clin Immunol, Sofia, Bulgaria.
C3 Medical University Sofia; Medical University Sofia
RP Gateva, A (corresponding author), Med Univ Sofia, Univ Hosp Alexandrovska, Clin Endocrinol, 1 Georgi Sofiiski Str, Sofia 1431, Bulgaria.
EM tony_gateva@yahoo.com
RI Gateva, Antoaneta/AGT-4861-2022; Assyov, Yavor/LWI-7733-2024; Velikova,
   Tsvetelina/H-6932-2019
OI Velikova, Tsvetelina/0000-0002-0593-1272; Assyov,
   Yavor/0000-0002-6195-7346
FU Medical University - Sofia, Medical Sciences Council Project
   [5272/30.07.2014/Contract 2- C/2014]
FX The study was conducted with the financial support of Medical University
   - Sofia, Medical Sciences Council - Project 5272/30.07.2014/Contract 2-
   C/2014. The sponsor had no role in study design, collection, analysis
   and interpretation of data, writing of the report, and in the decision
   to submit the article for publication.
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NR 24
TC 15
Z9 15
U1 0
U2 7
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 0743-5800
EI 1532-4206
J9 ENDOCR RES
JI Endocr. Res.
PY 2017
VL 42
IS 2
BP 163
EP 168
DI 10.1080/07435800.2017.1286671
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA ES6KH
UT WOS:000399655700012
PM 28406338
DA 2025-06-11
ER

PT J
AU Dupas, J
   Goanvec, C
   Feray, A
   Guernec, A
   Alain, C
   Guerrero, F
   Mansourati, J
AF Dupas, Julie
   Goanvec, Christelle
   Feray, Annie
   Guernec, Anthony
   Alain, Charlene
   Guerrero, Francois
   Mansourati, Jacques
TI Progressive Induction of Type 2 Diabetes: Effects of a Reality-Like
   Fructose Enriched Diet in Young Wistar Rats
SO PLOS ONE
LA English
DT Article
ID CORONARY-HEART-DISEASE; INSULIN-RESISTANCE; OXIDATIVE STRESS;
   CARDIAC-HYPERTROPHY; METABOLIC SYNDROME; GLUCOSE-TOLERANCE; FATTY-ACIDS;
   HOMA-IR; HYPERTENSION; NEPHROPATHY
AB Purpose
   The aim of this study was to characterize short and medium-lasting effects of fructose supplementation on young Wistar rats. The diet was similar to actual human consumption.
   Methods
   Three week old male rats were randomly divided into 2 groups: control (C; n = 16), fructose fed (FF; n = 16) with a fructose enriched drink for 6 or 12 weeks. Bodyweight, fasting glycemia and systolic blood pressure were monitored. Glucose tolerance was evaluated using an oral glucose tolerance test. Insulinemia was measured concomitantly and enable us to calculate insulin resistance markers (HOMA-IR, Insulin Sensitivity Index for glycemia: ISI-gly). Blood chemistry analyses were performed.
   Results
   After six weeks of fructose supplementation, rats were not overweight but presented increased fasting glycemia, reduced glucose tolerance, and lower insulin sensitivity compared to control group. Systolic blood pressure and heart weight were also increased without any change in renal function (theoretical creatinine clearance). After twelve weeks of fructose supplementation, FF rats had increased bodyweight and presented insulin resistance (higher HOMA-IR, lower ISI-gly). Rats also presented higher heart volume and lower ASAT/ALAT ratio (presumed liver lesion). Surprisingly, the Total Cholesterol/Triglycerides ratio was increased only after six weeks of fructose supplementation, predicting a higher LDL presence and thus a higher risk of developing cardiovascular disease. This risk was no longer present after twelve weeks of a fructose enriched diet.
   Conclusion
   On young Wistar rats, six weeks of fructose supplementation is sufficient to induce signs of metabolic syndrome. After twelve weeks of fructose enriched diet, rats are insulin resistant. This model enabled us to study longitudinally the early development of type 2 diabetes.
C1 [Dupas, Julie; Goanvec, Christelle; Feray, Annie; Guernec, Anthony; Alain, Charlene; Guerrero, Francois; Mansourati, Jacques] Univ Bretagne Occidentale, Optimisat Regulat Physiol, Brest, France.
   [Goanvec, Christelle] Univ Bretagne Occidentale, UFR Sci & Tech, Brest, France.
   [Feray, Annie; Guernec, Anthony; Guerrero, Francois] Univ Bretagne Occidentale, UFR Sport & Educ Phys, Brest, France.
   [Mansourati, Jacques] CHU Brest, Dept Cardiol, F-29285 Brest, France.
C3 Universite de Bretagne Occidentale; Universite de Bretagne Occidentale;
   Universite de Bretagne Occidentale; CHU Brest
RP Dupas, J (corresponding author), Univ Bretagne Occidentale, Optimisat Regulat Physiol, Brest, France.
EM julie.dupas@univ-brest.fr
RI Mansourati, Jacques/HLQ-5147-2023
OI goanvec, christelle/0000-0002-1764-6778; Guerrero,
   Francois/0000-0002-0283-3503
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NR 45
TC 29
Z9 31
U1 1
U2 7
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JAN 22
PY 2016
VL 11
IS 1
AR e0146821
DI 10.1371/journal.pone.0146821
PG 13
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA DB6WB
UT WOS:000368655300039
PM 26799836
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Wang, JJ
   Wu, ZL
   Li, DF
   Li, N
   Dindot, SV
   Satterfield, MC
   Bazer, FW
   Wu, GY
AF Wang, Junjun
   Wu, Zhenlong
   Li, Defa
   Li, Ning
   Dindot, Scott V.
   Satterfield, M. Carey
   Bazer, Fuller W.
   Wu, Guoyao
TI Nutrition, Epigenetics, and Metabolic Syndrome
SO ANTIOXIDANTS & REDOX SIGNALING
LA English
DT Review
ID HIGH-FAT DIET; MATERNAL NUTRIENT RESTRICTION; INTRAUTERINE
   GROWTH-RETARDATION; L-ARGININE SUPPLEMENTATION; ACTIVATED
   PROTEIN-KINASE; CORONARY-HEART-DISEASE; DNA METHYLATION;
   GENE-EXPRESSION; FETAL-GROWTH; DEVELOPMENTAL ORIGINS
AB Significance: Epidemiological and animal studies have demonstrated a close link between maternal nutrition and chronic metabolic disease in children and adults. Compelling experimental results also indicate that adverse effects of intrauterine growth restriction on offspring can be carried forward to subsequent generations through covalent modifications of DNA and core histones. Recent Advances: DNA methylation is catalyzed by S-adenosylmethionine-dependent DNA methyltransferases. Methylation, demethylation, acetylation, and deacetylation of histone proteins are performed by histone methyltransferase, histone demethylase, histone acetyltransferase, and histone deacetyltransferase, respectively. Histone activities are also influenced by phosphorylation, ubiquitination, ADP-ribosylation, sumoylation, and glycosylation. Metabolism of amino acids (glycine, histidine, methionine, and serine) and vitamins (B6, B12, and folate) plays a key role in provision of methyl donors for DNA and protein methylation. Critical Issues: Disruption of epigenetic mechanisms can result in oxidative stress, obesity, insulin resistance, diabetes, and vascular dysfunction in animals and humans. Despite a recognized role for epigenetics in fetal programming of metabolic syndrome, research on therapies is still in its infancy. Possible interventions include: 1) inhibition of DNA methylation, histone deacetylation, and microRNA expression; 2) targeting epigenetically disturbed metabolic pathways; and 3) dietary supplementation with functional amino acids, vitamins, and phytochemicals. Future Directions: Much work is needed with animal models to understand the basic mechanisms responsible for the roles of specific nutrients in fetal and neonatal programming. Such new knowledge is crucial to design effective therapeutic strategies for preventing and treating metabolic abnormalities in offspring born to mothers with a previous experience of malnutrition. Antioxid. Redox Signal. 17, 282-301.
C1 [Wu, Guoyao] Texas A&M Univ, Kleberg Ctr, Dept Anim Sci, College Stn, TX 77843 USA.
   [Dindot, Scott V.] Texas A&M Univ, Dept Mol & Cellular Med, College Stn, TX 77843 USA.
   [Dindot, Scott V.] Texas A&M Univ, Dept Vet Pathobiol, College Stn, TX 77843 USA.
   [Dindot, Scott V.; Satterfield, M. Carey; Bazer, Fuller W.; Wu, Guoyao] Texas A&M Univ, Ctr Anim Biotechnol & Genom, College Stn, TX 77843 USA.
   [Li, Ning] China Agr Univ, State Key Lab AgroBiotechnol, Beijing 100094, Peoples R China.
   [Wang, Junjun; Wu, Zhenlong; Li, Defa; Wu, Guoyao] China Agr Univ, State Key Lab Anim Nutr, Beijing 100094, Peoples R China.
C3 Texas A&M University System; Texas A&M University College Station; Texas
   A&M University System; Texas A&M University College Station; Texas A&M
   University System; Texas A&M University College Station; Texas A&M
   University System; Texas A&M University College Station; China
   Agricultural University; China Agricultural University
RP Wu, GY (corresponding author), Texas A&M Univ, Kleberg Ctr, Dept Anim Sci, Room 212, College Stn, TX 77843 USA.
EM g-wu@tamu.edu
RI Bazer, Fuller/AAF-4317-2021; Wang, Junjun/G-8893-2011
FU China Agricultural University; National Natural Science Foundation of
   China [3081010390, 30972156, 31129006, 31172217]; National Institutes of
   Health [1R21 HD049449]; American Heart Association [10GRNT4480020];
   National Research Initiative [2008-35203-19120]; USDA National Institute
   of Food and Agriculture [2008-35206-18764, 2009-35206-05211]; Texas
   AgriLife Research Hatch Project [H-8200]
FX This work was supported, in part, by grants from the
   Thousand-People-Talent program at China Agricultural University,
   National Natural Science Foundation of China (3081010390, 30972156,
   31129006, and 31172217), National Institutes of Health (1R21 HD049449),
   American Heart Association (10GRNT4480020), National Research Initiative
   Competitive Grants from the Animal Reproduction Program
   (2008-35203-19120), and Animal Growth & Nutrient Utilization Program
   (2008-35206-18764 and 2009-35206-05211) of the USDA National Institute
   of Food and Agriculture, and Texas AgriLife Research Hatch Project
   (H-8200).
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NR 212
TC 201
Z9 214
U1 5
U2 141
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1523-0864
EI 1557-7716
J9 ANTIOXID REDOX SIGN
JI Antioxid. Redox Signal.
PD JUL
PY 2012
VL 17
IS 2
BP 282
EP 301
DI 10.1089/ars.2011.4381
PG 20
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 944MQ
UT WOS:000304207700008
PM 22044276
OA Green Published
DA 2025-06-11
ER

PT J
AU Kuniyasu, A
   Tokunaga, M
   Yamamoto, T
   Inoue, S
   Obama, K
   Kawahara, K
   Nakayama, H
AF Kuniyasu, Akihiko
   Tokunaga, Mariko
   Yamamoto, Takashi
   Inoue, Shoko
   Obama, Keiko
   Kawahara, Kohichi
   Nakayama, Hitoshi
TI Oxidized LDL and lysophosphatidylcholine stimulate plasminogen activator
   inhibitor-1 expression through reactive oxygen species generation and
   ERK1/2 activation in 3T3-L1 adipocytes
SO BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
LA English
DT Article
DE Oxidized LDL; Plasminogen activator inhibitor-1; Adipocytes;
   Lysophosphatidylcholine; Reactive oxygen species; Extracellular
   signal-regulated kinase
ID LOW-DENSITY-LIPOPROTEIN; NECROSIS-FACTOR-ALPHA; VASCULAR
   ENDOTHELIAL-CELLS; ADIPOSE-TISSUE; INSULIN-RESISTANCE; METABOLIC
   SYNDROME; OXIDATIVE STRESS; VISCERAL FAT; OBESITY; INDUCTION
AB Plasminogen activator inhibitor-1 (PAI-1) is secreted from adipose tissue and is considered to be a risk factor for both atherosclerosis and insulin resistance. Here we report for the first time that PAI-1 expression is enhanced by oxidized low-density lipoprotein (OxLDL) and its lipid component lysophosphatidylcholine (LPC) in mouse 3T3-L1 adipocytes. In fully differentiated 3T3-L1 cells, OxLDL treatment increased the mRNA expression and protein secretion of PAI-1 in a dose- and time-dependent manner, whereas native LDL had no effect The addition of an anti-CD36 antibody suppressed OxLDL-stimulated PAI-1 expression by 50%, suggesting that adipose-derived CD36 contributes to roughly half of the PAI-1 expression stimulated by OxLDL In addition, pharmacological experiments showed that the OxLDL-stimulated enhancement in PAI-1 expression was mediated through the generation of reactive oxygen species (ROS) and phosphorylation of extracellular signal-regulated kinase 1/2. Furthermore, LPC, a major lipid component of OxLDL, was responsible for the enhanced expression of PAI-1 as phospholipase A(2)-treated acetyl LDL, which generates LPC, strongly stimulated PAI-1 expression, whereas acetyl LDL itself had no such activity. These data demonstrate that the uptake of OxLDL and, in particular, its lipid component LPC into adipocytes triggers aberrant ROS-mediated PAI-1 expression, which may be involved in the pathogenesis of metabolic syndrome. (C) 2010 Published by Elsevier B.V.
C1 [Kuniyasu, Akihiko; Tokunaga, Mariko; Yamamoto, Takashi; Inoue, Shoko; Obama, Keiko; Kawahara, Kohichi; Nakayama, Hitoshi] Kumamoto Univ, Dept Pharmaceut Biochem, Fac Life Sci, Kumamoto 8620973, Japan.
C3 Kumamoto University
RP Kuniyasu, A (corresponding author), Kumamoto Univ, Dept Pharmaceut Biochem, Fac Life Sci, 5-1 Oe Honmachi, Kumamoto 8620973, Japan.
EM kuniyasu@gpo.kumamotoo-u.ac.jp
FU Ministry of Education, Culture, Sports, Science and Technology of Japan
   [20590105]; Daiwa Securities Heath Foundation; Grants-in-Aid for
   Scientific Research [20590105] Funding Source: KAKEN
FX We thank Profs S. Horiuchi and A. Miyazaki, and Dr. R. Nagai for the
   helpful discussion, Ms. C Kawahara and T. Kayajima for excellent
   technical assistance. This study was supported in part by Daiwa
   Securities Heath Foundation, a Grant-in-Aid from the Ministry of
   Education, Culture, Sports, Science and Technology of Japan (No.
   20590105).
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NR 50
TC 34
Z9 36
U1 1
U2 22
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1388-1981
J9 BBA-MOL CELL BIOL L
JI Biochim. Biophys. Acta Mol. Cell Biol. Lipids
PD MAR
PY 2011
VL 1811
IS 3
BP 153
EP 162
DI 10.1016/j.bbalip.2010.11.011
PG 10
WC Biochemistry & Molecular Biology; Biophysics; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Cell Biology
GA 746TI
UT WOS:000289270200005
PM 21146630
DA 2025-06-11
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PT J
AU Liu, XL
   Liu, L
   Zhao, JF
   Wang, H
   Li, YF
AF Liu, Xiaoliang
   Liu, Lei
   Zhao, Junfei
   Wang, Hua
   Li, Yifei
TI Mechanotransduction regulates inflammation responses of epicardial
   adipocytes in cardiovascular diseases
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Review
DE adipocyte; cardiomyocytes; mechanotransduction; cardiovascular diseases;
   crosstalk
ID ADIPOSE-TISSUE INFLAMMATION; RIGHT-VENTRICULAR CARDIOMYOPATHY; ACTIVATED
   PROTEIN-KINASES; BODY-FAT DISTRIBUTION; MEK-ERK PATHWAY; CARDIAC
   DYSFUNCTION; INSULIN-RESISTANCE; HEART-FAILURE; STEM-CELLS; OSTEOGENIC
   DIFFERENTIATION
AB Adipose tissue is a crucial regulator in maintaining cardiovascular homeostasis by secreting various bioactive products to mediate the physiological function of the cardiovascular system. Accumulating evidence shows that adipose tissue disorders contribute to several kinds of cardiovascular disease (CVD). Furthermore, the adipose tissue would present various biological effects depending on its tissue localization and metabolic statuses, deciding the individual cardiometabolic risk. Crosstalk between adipose and myocardial tissue is involved in the pathophysiological process of arrhythmogenic right ventricular cardiomyopathy (ARVC), cardiac fibrosis, heart failure, and myocardial infarction/atherosclerosis. The abnormal distribution of adipose tissue in the heart might yield direct and/or indirect effects on cardiac function. Moreover, mechanical transduction is critical for adipocytes in differentiation, proliferation, functional maturity, and homeostasis maintenance. Therefore, understanding the features of mechanotransduction pathways in the cellular ontogeny of adipose tissue is vital for underlining the development of adipocytes involved in cardiovascular disorders, which would preliminarily contribute positive implications on a novel therapeutic invention for cardiovascular diseases. In this review, we aim to clarify the role of mechanical stress in cardiac adipocyte homeostasis and its interplay with maintaining cardiac function.
C1 [Liu, Xiaoliang; Liu, Lei; Wang, Hua; Li, Yifei] West China Second Univ Hosp, Sichuan Univ, Dept Pediat, Key Lab Birth Defects & Related Dis Women & Childr, Chengdu, Sichuan, Peoples R China.
   [Zhao, Junfei] Guangdong Acad Med Sci, Guangdong Prov Peoples Hosp, Guangdong Cardiovasc Inst, Dept Cardiovasc Surg, Guangzhou, Guangdong, Peoples R China.
C3 Sichuan University; Southern Medical University - China; Guangdong
   Academy of Medical Sciences & Guangdong General Hospital
RP Wang, H; Li, YF (corresponding author), West China Second Univ Hosp, Sichuan Univ, Dept Pediat, Key Lab Birth Defects & Related Dis Women & Childr, Chengdu, Sichuan, Peoples R China.; Zhao, JF (corresponding author), Guangdong Acad Med Sci, Guangdong Prov Peoples Hosp, Guangdong Cardiovasc Inst, Dept Cardiovasc Surg, Guangzhou, Guangdong, Peoples R China.
EM zhao_1990@outlook.com; wanghua@scu.edu.cn; liyfwcsh@scu.edu.cn
RI li, yifei/IWU-7824-2023; Li, Xia/GOK-1145-2022
OI Li, Yifei/0000-0002-3096-4287; liu, xiaoliang/0009-0008-0301-4025
FU Technology Project of Sichuan Province of China; National Natural
   Science Foundation of China;  [2021YFQ0061];  [2021YJ0171];  [82270249]
FX Funding This work was supported by grants from Technology Project of
   Sichuan Province of China (2021YFQ0061; 2021YJ0171) and the National
   Natural Science Foundation of China (82270249). The funding did not
   participate in the design of the study and collection, analysis, and
   interpretation of data and in writing the manuscript.
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NR 209
TC 8
Z9 8
U1 1
U2 19
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD DEC 16
PY 2022
VL 13
AR 1080383
DI 10.3389/fendo.2022.1080383
PG 18
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 7K0NV
UT WOS:000904983700001
PM 36589802
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Rodríguez, A
   Catalan, V
   Ramírez, B
   Unamuno, X
   Portincasa, P
   Gómez-Ambrosi, J
   Frühbeck, G
   Becerril, S
AF Rodriguez, A.
   Catalan, V
   Ramirez, B.
   Unamuno, X.
   Portincasa, P.
   Gomez-Ambrosi, J.
   Fruhbeck, G.
   Becerril, Sara
TI Impact of adipokines and myokines on fat browning
SO JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
LA English
DT Article
DE Leptin; Fat browning; Adipokine; Myokine
ID WHITE ADIPOSE-TISSUE; ALTERNATIVELY ACTIVATED MACROPHAGES; NITRIC-OXIDE;
   SKELETAL-MUSCLE; OXIDATIVE STRESS; ADRENERGIC-STIMULATION;
   CARDIOMETABOLIC RISK; COLD-EXPOSURE; GROWTH-FACTOR; LEPTIN
AB Since the discovery of leptin in 1994, the adipose tissue (AT) is not just considered a passive fat storage organ but also an extremely active secretory and endocrine organ that secretes a large variety of hormones, called adipokines, involved in energy metabolism. Adipokines may not only contribute to AT dysfunction and obesity, but also in fat browning, a process that induces a phenotypic switch from energy-storing white adipocytes to thermogenic brown fat-like cells. The fat browning process and, consequently, thermogenesis can also be stimulated by physical exercise. Contracting skeletal muscle is a metabolically active tissue that participates in several endocrine functions through the production of bioactive factors, collectively termed myokines, proposed as the mediators of physical activity-induced health benefits. Myokines affect muscle mass, have profound effects on glucose and lipid metabolism, and promote browning and thermogenesis of white AT in an endocrine and/or paracrine manner. The present review focuses on the role of different myokines and adipokines in the regulation of fat browning, as well as in the potential cross-talk between AT and skeletal muscle, in order to control body weight, energy expenditure and thermogenesis.
C1 [Rodriguez, A.; Catalan, V; Ramirez, B.; Unamuno, X.; Gomez-Ambrosi, J.; Fruhbeck, G.; Becerril, Sara] Clin Univ Navarra, Metab Res Lab, Avda Pio XII,36, Pamplona 31008, Spain.
   [Rodriguez, A.; Catalan, V; Ramirez, B.; Unamuno, X.; Gomez-Ambrosi, J.; Fruhbeck, G.; Becerril, Sara] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr CIBEROBN, Seville, Spain.
   [Rodriguez, A.; Catalan, V; Ramirez, B.; Gomez-Ambrosi, J.; Fruhbeck, G.; Becerril, Sara] Inst Invest Sanitaria Navarra IdiSNA, Obes & Adipobiol Grp, Pamplona, Spain.
   [Unamuno, X.] Univ Navarra, Med Engn Lab, Pamplona, Spain.
   [Portincasa, P.] Univ Bari, Policlin Hosp, Dept Biomed Sci & Human Oncol, Clin Med A Murri,Med Sch, I-70124 Bari, Italy.
   [Fruhbeck, G.] Clin Univ Navarra, Dept Endocrinol & Nutr, Pamplona, Spain.
C3 University of Navarra; Instituto de Salud Carlos III; CIBER - Centro de
   Investigacion Biomedica en Red; CIBEROBN; University of Navarra;
   Universita degli Studi di Bari Aldo Moro; University of Navarra
RP Becerril, S (corresponding author), Clin Univ Navarra, Metab Res Lab, Avda Pio XII,36, Pamplona 31008, Spain.; Becerril, S (corresponding author), Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr CIBEROBN, Seville, Spain.; Becerril, S (corresponding author), Inst Invest Sanitaria Navarra IdiSNA, Obes & Adipobiol Grp, Pamplona, Spain.
EM sbecman@unav.es
RI Gómez-Ambrosi, Javier/D-2984-2017; Ramírez, Beatriz/I-1922-2017;
   Rodríguez, Amaia/D-3044-2019; portincasa, piero/J-7245-2018; Catalan,
   Victoria/H-3566-2017
OI Catalan, Victoria/0000-0002-7513-7509; Unamuno,
   Xabier/0000-0003-4260-1325
FU Instituto de Salud Carlos III [PI16/00221, PI16/01217, PI17/02183,
   PI17/02188]; fondos FEDER [PI16/00221, PI16/01217, PI17/02183,
   PI17/02188]; Department of Health of Gobierno de Navarra [61/2014]
FX This work was supported by the Instituto de Salud Carlos III and fondos
   FEDER (PI16/00221, PI16/01217, PI17/02183 and PI17/02188) and by the
   Department of Health of Gobierno de Navarra (61/2014). CIBER de
   Fisiopatologia de la Obesidad y Nutricion (CIBEROBN) is an initiative of
   the Instituto de Salud Carlos III, Spain.
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NR 155
TC 25
Z9 26
U1 1
U2 23
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1138-7548
EI 1877-8755
J9 J PHYSIOL BIOCHEM
JI J. Physiol. Biochem.
PD MAY
PY 2020
VL 76
IS 2
SI SI
BP 227
EP 240
DI 10.1007/s13105-020-00736-2
EA MAR 2020
PG 14
WC Biochemistry & Molecular Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Physiology
GA LW6MR
UT WOS:000523411700001
PM 32236810
DA 2025-06-11
ER

PT J
AU Mirtschink, P
   Jang, C
   Arany, Z
   Krek, W
AF Mirtschink, Peter
   Jang, Cholsoon
   Arany, Zoltan
   Krek, Wilhelm
TI Fructose metabolism, cardiometabolic risk, and the epidemic of coronary
   artery disease
SO EUROPEAN HEART JOURNAL
LA English
DT Review
DE Fructose; Cardiometabolic syndrome; Cardiac hypertrophy;
   Atherosclerosis; Nonalcoholic fatty liver disease; Diabetes type 2;
   Fructolysis; Ketohexokinase; Hypertension; Alternative splicing; SF3B1;
   HIF; Hypoxia
ID FATTY LIVER-DISEASE; DE-NOVO LIPOGENESIS; SUGAR-SWEETENED BEVERAGES;
   HEALTHY-YOUNG MEN; CARDIOVASCULAR-DISEASE; CORN SYRUP; DIETARY FRUCTOSE;
   ESC GUIDELINES; POSTPRANDIAL TRIGLYCERIDES; INSULIN SENSITIVITY
AB Despite strong indications that increased consumption of added sugars correlates with greater risks of developing cardiometabolic syndrome (CMS) and cardiovascular disease (CVD), independent of the caloric intake, the worldwide sugar consumption remains high. In considering the negative health impact of overconsumption of dietary sugars, increased attention is recently being given to the role of the fructose component of high-sugar foods in driving CMS. The primary organs capable of metabolizing fructose include liver, small intestine, and kidneys. In these organs, fructose metabolism is initiated by ketohexokinase (KHK) isoform C of the central fructose-metabolizing enzyme KHK. Emerging data suggest that this tissue restriction of fructose metabolism can be rescinded in oxygen-deprived environments. In this review, we highlight recent progress in understanding how fructose metabolism contributes to the development of major systemic pathologies that cooperatively promote CMS and CVD, reference recent insights into microenvironmental control of fructose metabolism under stress conditions and discuss how this understanding is shaping preventive actions and therapeutic approaches.
C1 [Mirtschink, Peter; Krek, Wilhelm] Swiss Fed Inst Technol, Inst Mol Hlth Sci, Dept Biol, Otto Stern Weg 7, CH-8093 Zurich, Switzerland.
   [Mirtschink, Peter] Univ Hosp Dresden, Inst Clin Chem & Lab Med, Dept Clin Pathobiochem, Fetscherstr 74, D-01307 Dresden, Germany.
   [Jang, Cholsoon; Arany, Zoltan] Univ Penn, Perelman Sch Med, Cardiovasc Inst, Dept Med, 11th Floor,3400 Civ Blvd, Philadelphia, PA 19104 USA.
   [Jang, Cholsoon; Arany, Zoltan] Univ Penn, Perelman Sch Med, Inst Diabet Obes & Metab, 11th Floor,3400 Civ Blvd, Philadelphia, PA 19104 USA.
C3 Swiss Federal Institutes of Technology Domain; ETH Zurich; Technische
   Universitat Dresden; Carl Gustav Carus University Hospital; University
   of Pennsylvania; University of Pennsylvania
RP Mirtschink, P (corresponding author), Swiss Fed Inst Technol, Inst Mol Hlth Sci, Dept Biol, Otto Stern Weg 7, CH-8093 Zurich, Switzerland.; Mirtschink, P (corresponding author), Univ Hosp Dresden, Inst Clin Chem & Lab Med, Dept Clin Pathobiochem, Fetscherstr 74, D-01307 Dresden, Germany.
EM peter.mirtschink@uniklinikum-dresden.de
OI Jang, Cholsoon/0000-0001-6651-4213
FU Swiss Heart Foundation; SNF Sinergia; NIH [NIDDK DK107667]
FX Grants from the Swiss Heart Foundation and SNF Sinergia to W. K.; and
   the NIH (NIDDK DK107667) to Z. A.
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NR 134
TC 68
Z9 75
U1 7
U2 50
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0195-668X
EI 1522-9645
J9 EUR HEART J
JI Eur. Heart J.
PD JUL 7
PY 2018
VL 39
IS 26
BP 2497
EP +
DI 10.1093/eurheartj/ehx518
PG 12
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA GM9GI
UT WOS:000438554000012
PM 29020416
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Fabbrini, E
   Sullivan, S
   Klein, S
AF Fabbrini, Elisa
   Sullivan, Shelby
   Klein, Samuel
TI Obesity and Nonalcoholic Fatty Liver Disease: Biochemical, Metabolic,
   and Clinical Implications
SO HEPATOLOGY
LA English
DT Review
ID HEPATIC INSULIN-RESISTANCE; ENDOPLASMIC-RETICULUM STRESS; SERUM ALANINE
   AMINOTRANSFERASE; DENSITY LIPOPROTEIN PRODUCTION; UNFOLDED PROTEIN
   RESPONSE; ELEMENT-BINDING PROTEIN; GASTRIC BYPASS-SURGERY;
   SKELETAL-MUSCLE; ADIPOSE-TISSUE; WEIGHT-LOSS
AB Obesity is associated with an increased risk of nonalcoholic fatty liver disease (NAFLD). Steatosis, the hallmark feature of NAFLD, occurs when the rate of hepatic fatty acid uptake from plasma and de novo fatty acid synthesis is greater than the rate of fatty acid oxidation and export (as triglyceride within very low-density lipoprotein). Therefore, an excessive amount of intrahepatic triglyceride (IHTG) represents an imbalance between complex interactions of metabolic events. The presence of steatosis is associated with a constellation of adverse alterations in glucose, fatty acid, and lipoprotein metabolism. It is likely that abnormalities in fatty acid metabolism, in conjunction with adipose tissue, hepatic, and systemic inflammation, are key factors involved in the development of insulin resistance, dyslipidemia, and other cardiometabolic risk factors associated with NAFLD. However, it is not clear whether NAFLD causes metabolic dysfunction or whether metabolic dysfunction is responsible for IHTG accumulation, or possibly both. Understanding the precise factors involved in the pathogenesis and pathophysiology of NAFLD will provide important insights into the mechanisms responsible for the cardiometabolic complications of obesity. (HEPATOLOGY 2010;51:679-689.)
C1 [Fabbrini, Elisa; Sullivan, Shelby; Klein, Samuel] Washington Univ, Sch Med, Ctr Human Nutr, St Louis, MO 63110 USA.
   [Fabbrini, Elisa; Sullivan, Shelby; Klein, Samuel] Washington Univ, Sch Med, Atkins Ctr Excellence Obes Med, St Louis, MO 63110 USA.
   [Fabbrini, Elisa] IRCCS San Raffaele, Dept Med Sci, Ctr Clin & Basic Res, Rome, Italy.
C3 Washington University (WUSTL); Washington University (WUSTL);
   Vita-Salute San Raffaele University; IRCCS Ospedale San Raffaele; IRCCS
   San Raffaele Pisana; Center Clinical & Basic Research
RP Klein, S (corresponding author), Washington Univ, Sch Med, Ctr Human Nutr, 660 S Euclid Ave,Box 8031, St Louis, MO 63110 USA.
EM sklein@wustl.edu
RI Klein, Samuel/HLX-8445-2023
FU National Institutes of Health [UL1 RR024992, DK 56341, DK 37948]
FX Supported by National Institutes of Health Grants UL1 RR024992 (Clinical
   and Translational Science Award), DK 56341 (Clinical Nutrition Research
   Unit), and DK 37948.
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NR 100
TC 1569
Z9 1765
U1 4
U2 243
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0270-9139
EI 1527-3350
J9 HEPATOLOGY
JI Hepatology
PD FEB
PY 2010
VL 51
IS 2
BP 679
EP 689
DI 10.1002/hep.23280
PG 11
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 550ME
UT WOS:000274131200037
PM 20041406
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Tomkins-Lane, CC
   Lafave, LMZ
   Parnell, JA
   Rempel, J
   Moriartey, S
   Andreas, Y
   Wilson, PM
   Hepler, C
   Ray, HA
   Hu, R
AF Tomkins-Lane, Christy C.
   Lafave, Lynne M. Z.
   Parnell, Jill A.
   Rempel, Jocelyn
   Moriartey, Stephanie
   Andreas, Yvette
   Wilson, Philip M.
   Hepler, Charles
   Ray, Heather A.
   Hu, Richard
TI The spinal stenosis pedometer and nutrition lifestyle intervention
   (SSPANLI): development and pilot
SO SPINE JOURNAL
LA English
DT Article
DE Lumbar spinal stenosis; Obesity; Physical activity; Nutrition; e-Health;
   Weight loss
ID LOW-BACK-PAIN; INCREASE PHYSICAL-ACTIVITY; OLDER-ADULTS; WEIGHT-LOSS;
   METABOLIC SYNDROME; DISC DEGENERATION; E-HEALTH; WALKING CAPACITY;
   ABDOMINAL-AORTA; RISK-FACTOR
AB BACKGROUND CONTEXT: Owing to mobility limitations, people with lumbar spinal stenosis (LSS) are at risk for diseases of inactivity, including obesity. Therefore, weight management in LSS is critical. Body mass index is the strongest predictor of function in LSS, suggesting that weight loss may promote physical activity and provide a unique treatment option. We propose a lifestyle modification approach of physical activity and nutrition education, delivered through an e-health platform.
   PURPOSE: The purpose of this study was to develop and pilot an e-health intervention aimed at increasing physical activity and decreasing fat mass in people with LSS.
   STUDY DESIGN: The study design was based on intervention development and pilot.
   PATIENT SAMPLE: Ten overweight or obese individuals with LSS were confirmed clinically and on imaging.
   OUTCOME MEASURES: Self-reported measures were food record, Short-Form 36 (SF-36), pain scales, Swiss Spinal Stenosis Symptom and Physical Function Scales, Oswestry Disability Index (ODI), Pain Catastrophizing Questionnaire, Tampa Scale for Kinesiophobia, Center for Epidemiologic Studies(Depression) Scale, Behavioral Regular in Exercise Questionnaire, and Regulation for Eating Behavior Scale and physiologic measures were dual-energy X-ray absorptiometry (DXA), blood draw, 7-day accelerometry, self-paced walking test, and balance test.
   METHODS: The e-health platform was developed. Intervention: during Week 1, participants received a pedometer and a personalized consultation with a dietitian and an exercise physiologist. For 12 weeks, participants logged on to the e-health Web site to access personal step goals, nutrition education videos, and a discussion board. Follow-up occurred at Week 13.
   RESULTS: Nine participants had a mean age of 67.5 +/- 66.7 years (60% women). Significant improvements were observed for fat mass (DXA), trunk fat mass, symptom severity (Swiss Symptom Scale), energy intake, maximum continuous activity (accelerometry), and mental health (SF-36) (p<.05). Nonsignificant improvements were observed for waist circumference, pain, ODI, and obesity biomarkers. Seventy percent lost weight, 50% increased walking capacity, and 60% increased quality of life. The mean increase in steps was 15%.
   CONCLUSIONS: The spinal stenosis pedometer and nutrition lifestyle intervention was shown to be feasible, attractive to participants, and effective in this small sample. This intervention provides people with LSS the opportunity to participate in their own health management, potentially improving access to care. Efficacy is currently being assessed in a randomized trial. (C) 2015 Elsevier Inc. All rights reserved.
C1 [Tomkins-Lane, Christy C.; Lafave, Lynne M. Z.; Parnell, Jill A.; Ray, Heather A.] Mt Royal Univ, Dept Phys Educ & Recreat Studies, Calgary, AB T3E 6K6, Canada.
   [Rempel, Jocelyn] Mt Royal Univ, Dept Nursing, Calgary, AB T3E 6K6, Canada.
   [Moriartey, Stephanie] Alberta Hlth Serv, Calgary, AB T2W 1S7, Canada.
   [Andreas, Yvette] Mt Royal Univ, Off Res Serv, Calgary, AB T3E 6K6, Canada.
   [Wilson, Philip M.] Brock Univ, Dept Kinesiol, St Catharines, ON L2S 3A1, Canada.
   [Hepler, Charles] Mt Royal Univ, Dept Comp Sci & Informat Syst, Calgary, AB T3E 6K6, Canada.
   [Hu, Richard] Univ Calgary, Foothills Med Ctr, Dept Surg, Calgary, AB T2N 5A1, Canada.
C3 Mount Royal University; Mount Royal University; Alberta Health Services
   (AHS); University of Calgary; Mount Royal University; Brock University;
   Mount Royal University; University of Calgary; University Calgary
   Hospital
RP Tomkins-Lane, CC (corresponding author), Mt Royal Univ, Dept Phys Educ & Recreat Studies, 4825 Mt Royal Gate SW, Calgary, AB T3E 6K6, Canada.
EM clane@mtroyal.ca
RI Lafave, Lynne/AAQ-7756-2021; Wilson, Philip/V-6519-2019; Parnell,
   Jill/AAA-3476-2021; Tomkins-Lane, Christy/H-5367-2016
OI Lafave, Lynne M.Z./0000-0002-9781-3213; Parnell,
   Jill/0000-0002-2936-0558
FU Mount Royal University Internal Grants
FX This study was funded through Mount Royal University Internal Grants.
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NR 76
TC 24
Z9 26
U1 1
U2 22
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1529-9430
EI 1878-1632
J9 SPINE J
JI Spine Journal
PD APR 1
PY 2015
VL 15
IS 4
BP 577
EP 586
DI 10.1016/j.spinee.2014.10.015
PG 10
WC Clinical Neurology; Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Orthopedics
GA CE2UX
UT WOS:000351676400008
PM 25452012
DA 2025-06-11
ER

PT J
AU AL-Mhanna, SB
   Batrakoulis, A
   Ghazali, WSW
   Mohamed, M
   Aldayel, A
   Alhussain, MH
   Afolabi, HA
   Wada, Y
   Gülü, M
   Elkholi, S
   Abubakar, BD
   Rojas-Valverde, D
AF AL-Mhanna, Sameer Badri
   Batrakoulis, Alexios
   Ghazali, Wan Syaheedah Wan
   Mohamed, Mahaneem
   Aldayel, Abdulaziz
   Alhussain, Maha H.
   Afolabi, Hafeez Abiola
   Wada, Yusuf
   Gulu, Mehmet
   Elkholi, Safaa
   Abubakar, Bishir Daku
   Rojas-Valverde, Daniel
TI Effects of combined aerobic and resistance training on glycemic control,
   blood pressure, in fl ammation, cardiorespiratory fi tness and quality
   of life in patients with type 2 diabetes and overweight/obesity: a
   systematic review and meta-analysis
SO PEERJ
LA English
DT Review
DE Exercise; Physical activity; Insulin resistance; Metabolic syndrome;
   Cardiometabolic health
ID CARDIOVASCULAR RISK; AMERICAN-COLLEGE; STRUCTURED EXERCISE; POSITION
   STATEMENT; OBESITY; MELLITUS; ASSOCIATION; INTERVENTION; STRENGTH;
   ADULTS
AB Background: Structured aerobic or resistance training alone seems to be a bene fi cial tool for improving glucose homeostasis, chronic systemic in fl ammation, resting cardiovascular function, and mental health in people with obesity and type 2 diabetes mellitus (T2DM). The aim of the present study was to synthesize the available data on the effectiveness of combined aerobic and resistance training (CART) on glycemic control, blood pressure, in fl ammation, cardiorespiratory fi tness (CRF), and quality of life (QoL) in overweight and obese individuals with T2DM. Methods: A database search was carried out in PubMed, Web of Science, Scopus, Science Direct, Cochrane Library, and Google Scholar from inception up to May 2023. The Cochrane risk of bias tool was used to assess eligible studies, and the GRADE method to evaluate the reliability of evidence. A random-effects model was used, and data were analyzed using standardized mean differences and 95% con fi dence intervals. The study protocol was registered in the International Prospective Register of Systematic Reviews (ID: CRD42022355612). Results: A total of 21,612 studies were retrieved; 20 studies were included, and data were extracted from 1,192 participants (mean age: 57 +/- 7 years) who met the eligibility criteria. CART demonstrated signi fi cant improvements in body mass index, glycated hemoglobin, systolic and diastolic blood pressure, C -reactive protein, tumor necrosis factor -alpha, interleukin-6, CRF, and QoL compared to ST. These fi ndings highlight the signi fi cance of exercise interventions such as CART as essential elements within comprehensive diabetes management strategies, ultimately enhancing overall health outcomes in individuals with T2DM and overweight/ obesity.No differences were found in resting heart rate between CART and ST. An uncertain risk of bias and poor quality of evidence were found among the eligible studies. Conclusion: These outcomes show clear evidence considering the positive role of CART in inducing bene fi cial changes in various cardiometabolic and mental health -related indicators in patients with T2DM and concurrent overweight/obesity. More studies with robust methodological design are warranted to examine the dose -response relationship, training parameters con fi guration, and mechanisms behind these positive adaptations.
C1 [AL-Mhanna, Sameer Badri; Ghazali, Wan Syaheedah Wan; Mohamed, Mahaneem] Univ Sains Malaysia, Sch Med Sci, Dept Physiol, Kelantan, Malaysia.
   [Batrakoulis, Alexios] Univ Thessaly, Sch Phys Educ Sport Sci & Dietet, Dept Phys Educ & Sport Sci, Trikala, Greece.
   [Aldayel, Abdulaziz] King Saud Univ, Exercise Physiol Lab, Riyadh 11423, Saudi Arabia.
   [Alhussain, Maha H.] King Saud Univ, Coll Food & Agr Sci, Dept Food Sci & Nutr, Riyadh, Saudi Arabia.
   [Afolabi, Hafeez Abiola] Univ Sains Malaysia, Sch Med Sci, Dept Gen Surg, Kelantan, Malaysia.
   [Wada, Yusuf] Ahmadu Bello Univ, Dept Zool, Zaria, Nigeria.
   [Gulu, Mehmet] Kirikkale Univ, Fac Sport Sci, Dept Sports Management, Kirikkale, Turkiye.
   [Elkholi, Safaa] Princess Nourah Bint Abdulrahman Univ, Coll Hlth & Rehabil Sci, Dept Rehabil Sci, Riyadh, Saudi Arabia.
   [Abubakar, Bishir Daku] Fed Univ Dutse, Dept Human Physiol, Jigawa, Nigeria.
   [Rojas-Valverde, Daniel] Univ Nacl Costa Rica, Escuela Ciencias Movimiento Humano & Calidad Vida, Ctr Invest & Diagnost Salud & Deporte, Heredia, Costa Rica.
C3 Universiti Sains Malaysia; University of Thessaly; King Saud University;
   King Saud University; Universiti Sains Malaysia; Ahmadu Bello
   University; Kirikkale University; Princess Nourah bint Abdulrahman
   University; Universidad Nacional Costa Rica
RP AL-Mhanna, SB; Ghazali, WSW (corresponding author), Univ Sains Malaysia, Sch Med Sci, Dept Physiol, Kelantan, Malaysia.
EM sameerbadri9@gmail.com; syaheeda@usm.my
RI Aldayel, Abdulaziz/M-3832-2013; AL-Mhanna, Sameer/LCD-8679-2024;
   Alhussain, Maha/ABC-3652-2020; ElKholi, Safaa/AAW-2576-2021; afolabi,
   hafeez/AGN-5924-2022; WADA, YUSUF/X-5241-2019; Batrakoulis,
   Alexios/AAE-4820-2022; Wan Ghazali, Wan Syamimee/ISV-4326-2023;
   Rojas-Valverde, Daniel/G-8045-2015; Gulu, Mehmet/AAP-8658-2020; Mohamed,
   Mahaneem/F-1159-2011
OI Gulu, Mehmet/0000-0001-7633-7900; WADA, YUSUF/0000-0003-0003-9581;
   Aldayel, Abdulaziz/0000-0002-8499-1117; Mohamed,
   Mahaneem/0000-0001-9333-1957
FU Universiti Sains Malaysia [304]
FX <B>Funding</B> This work was supported by the Universiti Sains Malaysia
   (Grant No. 304.PPSP.6315639) . The funders had no role in study design,
   data collection and analysis, decision to publish, or preparation of the
   manuscript.
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NR 112
TC 26
Z9 26
U1 3
U2 13
PU PEERJ INC
PI LONDON
PA 341-345 OLD ST, THIRD FLR, LONDON, EC1V 9LL, ENGLAND
SN 2167-8359
J9 PEERJ
JI PeerJ
PD JUN 14
PY 2024
VL 12
AR e17525
DI 10.7717/peerj.17525
PG 32
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA US9O0
UT WOS:001250166300003
PM 38887616
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Zhang, YP
   Hu, RX
   Han, M
   Lai, BY
   Liang, SB
   Chen, BJ
   Robinson, N
   Chen, K
   Liu, JP
AF Zhang, Ya-Peng
   Hu, Rui-Xue
   Han, Mei
   Lai, Bao-Yong
   Liang, Shi-Bing
   Chen, Bing-Jie
   Robinson, Nicola
   Chen, Kevin
   Liu, Jian-Ping
TI Evidence Base of Clinical Studies on Qi Gong: A Bibliometric Analysis
SO COMPLEMENTARY THERAPIES IN MEDICINE
LA English
DT Article
DE Qigong; Ba Duan Jin; Bibliometric Analysis; Clinical Study; Non-drug
   therapy
ID QUALITY-OF-LIFE; QIGONG; INDIVIDUALS; EXERCISES; DISEASE; ADULTS; IMPACT
AB Objective: This bibliometric study aimed to systematically and comprehensively summarize the volume, breadth and evidence for clinical research on Qigong. And this bibliometric analysis also can provide the evidence of this field. Design: Bibliometric analysis.
   Methods: All types of primary and secondary studies on humans were included: systematic reviews, randomized clinical trials, non-randomized controlled clinical studies, case series and case reports. Chinese Biomedical Literature Database, China National Knowledge Infrastructure, Chinese Scientific Journal Database, Chinese Academic Conference Papers Database and Chinese Dissertation Database, PubMed and the Cochrane Library were searched from the date of inception to December 10, 2018. Bibliometric information, such as publication information, disease/condition, Qigong intervention and research results were extracted and analyzed.
   Results: A total of 886 clinical studies were identified: including 47 systematic reviews, 705 randomized clinical trials, 116 non-randomized controlled clinical studies, 12 case series and 6 case reports. The studies were conducted in 14 countries. The top 15 diseases/conditions studied were: diabetes, chronic obstructive pulmonary disease, hypertension, stroke, cervical spondylosis, lumbar disc herniation, insomnia, knee osteoarthritis, low back pain, and osteoporosis, Coronary heart disease, breast cancer, periarthritis of shoulder, depression, metabolic syndrome. Of the various Qigong exercises reported in these 886 clinical studies, Ba Duan Jin was the most frequently researched in 492 (55.5%) studies, followed by Health Qigong 107 (12.1%), Dao Yin Shu 85 (9.6%), Wu Qin Xi 67 (7.6%) and Yi Jin Jing 66 (7.4%). The most frequently used comparisons in randomized trials were maintaining normal way of life unchanged 149 (18.1%), the remaining controls included conventional treatment, mainly western medicine, Chinese herbal medicine, acupuncture, health education, psychological therapy, Yoga, Tai Chi and other non-drug therapy. The most frequently reported outcomes were physical function, quality of life, symptoms, pain and mental health indicators. Beneficial results from practicing Qigong were reported in 97% of studies.
   Conclusions: Qigong research publications have been increasing gradually. Reports on study types, participants, Qigong Intervention, and outcomes are diverse and inconsistent. There is an urgent need to develop a set of reporting standards for various interventions of Qigong. Further trials of high methodological quality with sufficient sample size and real world studies are needed to verify the effects of Qigong in health and disease management.
C1 [Zhang, Ya-Peng; Hu, Rui-Xue; Han, Mei; Liang, Shi-Bing; Robinson, Nicola; Liu, Jian-Ping] Beijing Univ Chinese Med, Ctr Evidence Based Chinese Med, Beijing 100029, Peoples R China.
   [Hu, Rui-Xue] China Acad Chinese Med Sci, Ctr Evidence Based Tradit Chinese Med, Inst Basic Res Clin Med, Beijing, Peoples R China.
   [Lai, Bao-Yong] Beijing Universal Chinese Med, Affiliated Hosp 3, Beijing 100029, Peoples R China.
   [Liang, Shi-Bing] Shanxi Univ Tradit Chinese Med, Coll Basic Med Sci, Taiyuan 030000, Peoples R China.
   [Chen, Bing-Jie] Beijing Univ Chinese Med, Coll Tradit Chinese Med, Beijing 100029, Peoples R China.
   [Robinson, Nicola] London South Bank Univ, Sch Hlth & Social Care, London SE1 0AA, England.
   [Chen, Kevin] Univ Maryland, Sch Med, Ctr Integrat Med, College Pk, MD 20742 USA.
   [Chen, Kevin] ShenZhen Univ, Fac Phys Educ, Shenzhen, Peoples R China.
   [Zhang, Ya-Peng; Hu, Rui-Xue; Han, Mei; Lai, Bao-Yong; Liang, Shi-Bing; Chen, Bing-Jie; Robinson, Nicola; Chen, Kevin; Liu, Jian-Ping] Guangzhou Med Univ, Inst Integrated Tradit Chinese Med & Western Med, Guangzhou, Peoples R China.
C3 Beijing University of Chinese Medicine; China Academy of Chinese Medical
   Sciences; Institute of Basic Research In Clinical Medicine, CACMS;
   Beijing University of Chinese Medicine; London South Bank University;
   University System of Maryland; University of Maryland College Park;
   Shenzhen University; Guangzhou Medical University
RP Liu, JP (corresponding author), Beijing Univ Chinese Med, Ctr Evidence Based Chinese Med, Beijing 100029, Peoples R China.; Liu, JP (corresponding author), Guangzhou Med Univ, Inst Integrated Tradit Chinese Med & Western Med, Guangzhou, Peoples R China.
EM zhangyapeng@bucm.edu.cn; ruixue_hu@bucm.edu.cn; hanmeizoujin@163.com;
   by_lai@126.com; zyi20126185@163.com; tian8388@163.com;
   nicky.robinson@lsbu.ac.uk; KChen@som.umaryland.edu; Liujp@bucm.edu.cn
RI Chen, Kevin/JYO-4787-2024; Hu, Rui-xue/AAC-3527-2019
OI Hu, Rui-xue/0000-0002-1333-0485
FU key program of the National Natural Science Foundation of China
   [81830115]; Beijing University of Chinese Medicine [2016-ZXFZJJ-011];
   Overseas Expertise Project, Ministry of Education of China [MS20080009]
FX This work was supported by the key program of the National Natural
   Science Foundation of China (No. 81830115), and by Beijing University of
   Chinese Medicine funding project for the research and development of
   evidence base medicine of TCM clinical scientific research ability and
   international development (No.2016-ZXFZJJ-011); Prof. Nicola Robinson
   (visiting professor of Beijing UniUversity of Chinese Medicine) is
   funded by Overseas Expertise Project, Ministry of Education of
   China(MS20080009).
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NR 33
TC 51
Z9 51
U1 21
U2 188
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0965-2299
EI 1873-6963
J9 COMPLEMENT THER MED
JI Complement. Ther. Med.
PD MAY
PY 2020
VL 50
AR 102392
DI 10.1016/j.ctim.2020.102392
PG 8
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA LR4ZL
UT WOS:000535704900005
PM 32444061
OA hybrid, Green Accepted
DA 2025-06-11
ER

PT J
AU Salimi, M
   Eskandari, F
   Khodagholi, F
   Abdollahifar, MA
   Hedayati, M
   Zardooz, H
   Keyhanmanesh, R
AF Salimi, Mina
   Eskandari, Farzaneh
   Khodagholi, Fariba
   Abdollahifar, Mohammad-Amin
   Hedayati, Mehdi
   Zardooz, Homeira
   Keyhanmanesh, Rana
TI Perinatal stress exposure induced oxidative stress, metabolism disorder,
   and reduced GLUT-2 in adult offspring of rats
SO HORMONES-INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM
LA English
DT Article
DE Perinatal stress; Glucose metabolism; Oxidative stress; GLUT-2;
   Offspring
ID ISLETS INSULIN-SECRETION; PRENATAL STRESS; DEVELOPMENTAL ORIGINS;
   GLUCOSE-HOMEOSTASIS; MATERNAL EXPOSURE; FEEDING-BEHAVIOR; SOCIAL STRESS;
   LIFE STRESS; DEXAMETHASONE; GLUCOCORTICOIDS
AB Purpose Growing evidence has demonstrated that adversity in early life, especially in the prenatal and postnatal period, may change the programming of numerous body systems and cause the incidence of various disorders in later life. Accordingly, this experimental animal study aimed to investigate the effect of stress exposure during perinatal (prenatal and/or postnatal) on the induction of oxidative stress in the pancreas and its effect on glucose metabolism in adult rat offspring. Methods In this experimental study based on maternal exposure to variable stress throughout the perinatal period, the pups were divided into eight groups, as follows: control group (C); prepregnancy, pregnancy, lactation stress group (PPPLS); prepregnancy stress group (PPS); pregnancy stress group (PS); lactation stress group (LS); prepregnancy, pregnancy stress group (PPPS); pregnancy, lactation stress group (PLS); and prepregnancy, lactation stress group (PPLS). Following an overnight fast on postnatal day (PND) 64, plasma glucose, insulin, leptin levels, and lipid profiles were evaluated in the offspring groups. GLUT-2 protein levels, lipid peroxidation, antioxidant status, and number of beta-cells in the pancreatic islets of Langerhans as well as the weights of intra-abdominal fat and adrenal glands were assessed. Levels of plasma corticosterone were determined in the different groups of mothers and offspring. Results The levels of plasma corticosterone, insulin, and HOMA-B index increased, whereas glucose level and QUICKI index were reduced in the perinatal stress groups compared to C group (p < 0.001 to p < 0.05). Plasma triglyceride, LDL, and cholesterol level rose significantly, but HDL level decreased in the perinatal stress groups compared to C group (p < 0.001 to p < 0.05). Perinatal stress raised MDA concentrations and reduced the activities of antioxidant enzymes in plasma and pancreas compared to C group (p < 0.001 to p < 0.05). GLUT-2 protein levels and number of beta-cells in the stress groups declined compared to C group (p < 0.001 to p < 0.05). Intra-abdominal fat weight decreased in the PPS, PS, and LS groups compared to C group (p < 0.001 to p < 0.01), but adrenal gland weight remained unchanged. Conclusion Our results showed that long-term exposure to elevated levels of corticosterone during critical development induces metabolic syndrome in adult male rats.
C1 [Salimi, Mina; Keyhanmanesh, Rana] Tabriz Univ Med Sci, Fac Med, Dept Physiol, POB 5166614756, Tabriz, Iran.
   [Salimi, Mina] Tabriz Univ Med Sci, Student Res Comm, Tabriz, Iran.
   [Eskandari, Farzaneh; Zardooz, Homeira] Shahid Beheshti Univ Med Sci, Sch Med, Dept Physiol, POB 19615-1178, Tehran, Iran.
   [Khodagholi, Fariba] Shahid Beheshti Univ Med Sci, Neurosci Res Ctr, Tehran, Iran.
   [Abdollahifar, Mohammad-Amin] Shahid Beheshti Univ Med Sci, Sch Med, Dept Biol & Anat Sci, Tehran, Iran.
   [Hedayati, Mehdi] Shahid Beheshti Univ Med Sci, Res Inst Endocrine Sci, Cellular & Mol Endocrine Res Ctr, Tehran, Iran.
   [Keyhanmanesh, Rana] Tabriz Univ Med Sci, Drug Appl Res Ctr, Tabriz, Iran.
C3 Tabriz University of Medical Science; Tabriz University of Medical
   Science; Shahid Beheshti University Medical Sciences; Shahid Beheshti
   University Medical Sciences; Shahid Beheshti University Medical
   Sciences; Shahid Beheshti University Medical Sciences; Tabriz University
   of Medical Science
RP Keyhanmanesh, R (corresponding author), Tabriz Univ Med Sci, Fac Med, Dept Physiol, POB 5166614756, Tabriz, Iran.; Zardooz, H (corresponding author), Shahid Beheshti Univ Med Sci, Sch Med, Dept Physiol, POB 19615-1178, Tehran, Iran.; Keyhanmanesh, R (corresponding author), Tabriz Univ Med Sci, Drug Appl Res Ctr, Tabriz, Iran.
EM homeira_zardooz@sbmu.ac.ir; rkeyhanmanesh@gmail.com
RI Hedayati, Mehdi/AAG-3006-2019; Salimi, Mina/GPK-8299-2022; Khodagholi,
   Fariba/AAZ-4436-2020; zardooz, homeira/V-5293-2019; Keyhanmanesh,
   Rana/O-6536-2018
OI Keyhanmanesh, Rana/0000-0002-6941-2690; Salimi, M/0000-0001-9419-1490;
   Eskandari, Farzaneh/0000-0002-6704-6279
FU Drug applied research center of Tabriz University of Medical Sciences
   [60218]; Research Deputy of School of Medicine, Shahid Beheshti
   University of Medical Sciences [27310]
FX The results described in this paper were part of a PhD student thesis
   and were supported by a grant from Drug applied research center of
   Tabriz University of Medical Sciences (grant no 60218) and a grant from
   Research Deputy of School of Medicine, Shahid Beheshti University of
   Medical Sciences (grant no 27310).
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NR 81
TC 4
Z9 4
U1 0
U2 5
PU SPRINGER INT PUBL AG
PI CHAM
PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND
SN 1109-3099
EI 2520-8721
J9 HORM-INT J ENDOCRINO
JI Horm.-Int. J. Endocrinol. Metab.
PD DEC
PY 2022
VL 21
IS 4
BP 625
EP 640
DI 10.1007/s42000-022-00383-w
EA JUL 2022
PG 16
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 6S5HN
UT WOS:000826262800001
PM 35843978
DA 2025-06-11
ER

PT J
AU Hsu, HE
   Chen, PY
   Chang, HM
   Pan, CH
   Su, SS
   Tsai, SY
   Chen, CC
   Kuo, CJ
AF Hsu, Haw-En
   Chen, Po-Yu
   Chang, Hu-Ming
   Pan, Chun-Hung
   Su, Sheng-Shiang
   Tsai, Shang-Ying
   Chen, Chiao-Chicy
   Kuo, Chian-Jue
TI Incidence of and risk factors for alcohol dependence in bipolar
   disorder: A population-based cohort and nested case-control study
SO AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
LA English
DT Article
DE Alcohol dependence; alcohol use disorder; bipolar disorder; comorbidity;
   incidence
ID METABOLIC SYNDROME; ANXIETY DISORDERS; SUBSTANCE-ABUSE; IMPACT;
   COMORBIDITY; MORTALITY; PREVALENCE; DISEASE
AB Objectives: Although alcohol dependence is highly prevalent in patients with bipolar disorder, the causal relationship is not yet well-established. This study estimated the incidence of alcohol dependence in a nationwide bipolar disorder cohort and examined risk factors for alcohol dependence. Methods: Patients aged 15-65 years with consistent bipolar disorder who had their first psychiatric admission between 1999 and 2012 (n = 21,791) were enrolled from the National Health Insurance Research Database in Taiwan. We calculated the adjusted incidence rate ratio of alcohol dependence in the bipolar cohort relative to the general population after stratification by age and sex. In the nested case-control study, we included patients with incident alcohol dependence as cases and four age- and sex-matched controls for each case to analyze health care utilization, comorbidities and concomitant medications between them. Results: We identified 1261 patients with bipolar disorder with incident alcohol dependence. Relative to the general population, the adjusted incidence rate ratio of alcohol dependence was 9.20 in the bipolar cohort. All adjusted incidence rate ratios were high across all age subgroups. Cases had higher psychiatric and nonpsychiatric health care utilization than did controls. Multivariate analysis revealed that cases tended to have cardiovascular disease, diabetes mellitus, chronic hepatic disease, pneumonia and delirium before alcohol dependence diagnosis. Cases had higher psychiatric comorbidities, namely drug-induced mental disorders, anxiety disorder, personality disorder, adjustment disorder and sleep disorder. Conclusion: The bipolar cohort had a higher incidence of alcohol dependence. We identified specific groups with a high risk of alcohol dependence. Additional strategies for early detection, treatment and intervention for alcohol dependence should be developed.
C1 [Hsu, Haw-En; Chen, Po-Yu; Chang, Hu-Ming; Pan, Chun-Hung; Su, Sheng-Shiang; Kuo, Chian-Jue] Taipei City Hosp, Dept Gen Psychiat, Taipei City Psychiat Ctr, 309 Sung Te Rd, Taipei 110, Taiwan.
   [Pan, Chun-Hung] Natl Chengchi Univ, Dept Psychol, Taipei, Taiwan.
   [Tsai, Shang-Ying; Chen, Chiao-Chicy; Kuo, Chian-Jue] Taipei Med Univ, Sch Med, Dept Psychiat, Coll Med, Taipei, Taiwan.
   [Tsai, Shang-Ying; Kuo, Chian-Jue] Taipei Med Univ Hosp, Psychiat Res Ctr, Taipei, Taiwan.
   [Chen, Chiao-Chicy] Mackay Mem Hosp, Dept Psychiat, Taipei, Taiwan.
   [Chen, Chiao-Chicy] Mackay Med Coll, Dept Psychiat, Taipei, Taiwan.
C3 Taipei City Hospital; National Chengchi University; Taipei Medical
   University; Taipei Medical University; Taipei Medical University
   Hospital; Mackay Memorial Hospital; Mackay Medical College
RP Kuo, CJ (corresponding author), Taipei City Hosp, Dept Gen Psychiat, Taipei City Psychiat Ctr, 309 Sung Te Rd, Taipei 110, Taiwan.
EM tcpckuo@seed.net.tw
RI Chang, Hui/AGD-4270-2022; Chen, Hsing-yu/C-3979-2011; Chen,
   Pao-Huan/ABG-5963-2020
OI TSAI, SHANGYING/0000-0001-5662-0055; Pan, Chun-Hung/0000-0002-8542-558X
FU Ministry of Science and Technology, Taiwan [MOST 108-2314-B-532-005,
   110-2314-B-532-003-MY3]; Taipei City Hospital, Taiwan [10901-62-009,
   10901-62-055, 11001-62-006, 11101-62003]
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship and/or publication of this article: This
   research was supported by grants from the Ministry of Science and
   Technology, Taiwan (MOST 108-2314-B-532-005 and 110-2314-B-532-003-MY3)
   and Taipei City Hospital, Taiwan (10901-62-009, 10901-62-055,
   11001-62-006 and 11101-62003). Neither of the funding sources had any
   role in conducting the research, analyzing the data or writing this
   report.
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NR 40
TC 0
Z9 0
U1 1
U2 6
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0004-8674
EI 1440-1614
J9 AUST NZ J PSYCHIAT
JI Aust. N. Z. J. Psych.
PD MAY
PY 2023
VL 57
IS 5
BP 725
EP 735
AR 00048674221100153
DI 10.1177/00048674221100153
EA JUN 2022
PG 11
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA F9CL4
UT WOS:000806954900001
PM 35642594
DA 2025-06-11
ER

PT J
AU Min, SH
   Yang, Q
   Docherty, SL
   Lee, CY
AF Min, Se Hee
   Yang, Qing
   Docherty, Sharron L.
   Lee, Chiyoung
TI Comparison of Symptoms Between Midlife Women in Perimenopause and
   Postmenopause Using Network Comparison Test
SO WESTERN JOURNAL OF NURSING RESEARCH
LA English
DT Article
DE menopause; midlife; symptom; women
ID MENOPAUSAL TRANSITION; DEPRESSIVE SYMPTOMS; VASOMOTOR SYMPTOMS;
   METABOLIC SYNDROME; HORMONAL CHANGES; HEALTH; ANXIETY; PREVALENCE;
   CLUSTERS; COHORT
AB Introduction: Midlife women in perimenopause and postmenopause experience a complex array of symptoms. However, there is conflicting evidence on how their symptom experiences differ by menopausal stage. Current studies have not examined the interconnected relationship among menopausal symptoms and understood how this relationship may differ based on the menopausal stage.Methods: This is a secondary data analysis using cross-sectional data (visit 5) from the Study of Women's Health Across the Nation. Network analysis was used to visualize the network structure and to identify key symptoms. Then, a network comparison test was conducted to compare the symptom network properties. Propensity score matching was used to match participants in terms of their covariates.Results: In midlife women in perimenopause, frequent mood change was the key symptom with the highest strength (1.59), closeness (1.27), and expected influence (1.62). In midlife women in postmenopause, anxiety was the key symptom with the highest closeness (0.95) and expected influence (1.48). The symptom networks were not significantly different between the 2 groups in terms of global strength (global strength = 0.01, P = .974), network structure (network structure = 0.10, P = .461), and specific centrality measure (centrality = -0.10, P = .083). While the symptom networks were not invariant, the key symptoms were different between the 2 groups.Conclusion: Our study findings indicate a potential need for different symptom management approaches for midlife women in perimenopause and postmenopause. With this new knowledge, clinicians should offer targeted key symptom assessment and management.
C1 [Min, Se Hee] Univ Penn, Sch Nursing, 418 Curie Blvd, Philadelphia, PA 19104 USA.
   [Yang, Qing; Docherty, Sharron L.] Duke Univ, Sch Nursing, Durham, NC USA.
   [Lee, Chiyoung] Univ Arizona, Coll Nursing, Tucson, AZ USA.
C3 University of Pennsylvania; Duke University; University of Arizona
RP Min, SH (corresponding author), Univ Penn, Sch Nursing, 418 Curie Blvd, Philadelphia, PA 19104 USA.
EM seheemin@upenn.edu
OI Yang, Qing/0000-0003-4844-4690
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NR 49
TC 0
Z9 0
U1 1
U2 1
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0193-9459
EI 1552-8456
J9 WESTERN J NURS RES
JI West. J. Nurs. Res.
PD JUL
PY 2025
VL 47
IS 7
BP 630
EP 640
DI 10.1177/01939459251333669
EA APR 2025
PG 11
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA 3FM4A
UT WOS:001465318200001
PM 40219976
DA 2025-06-11
ER

PT J
AU Barnes, TRE
   MacCabe, JH
   Kane, JM
   Delgado, O
   Paton, C
AF Barnes, Thomas R. E.
   MacCabe, James H.
   Kane, John M.
   Delgado, Oriana
   Paton, Carol
TI The physical health and side-effect monitoring of patients prescribed
   clozapine: data from a clinical audit conducted in UK mental health
   services
SO THERAPEUTIC ADVANCES IN PSYCHOPHARMACOLOGY
LA English
DT Article
DE antipsychotic medication; clozapine; physical health monitoring; quality
   improvement; schizophrenia; side effects
ID INDUCED MYOCARDITIS; METABOLIC SYNDROME; REFRACTORY SCHIZOPHRENIA;
   MANAGEMENT; AUGMENTATION; PREVALENCE; GUIDELINES; RISK; SAFETY; CARE
AB Background: In addition to mandatory haematological monitoring, treatment guidelines recommend routine monitoring of adverse effects and physical health in patients prescribed clozapine.
   Methods: NHS trusts/healthcare organisations participated in a clinical audit in the context of a UK quality improvement programme addressing clozapine-prescribing practice.
   Results: Data relating to 6948 adult patients prescribed clozapine were submitted by 63 NHS trusts/healthcare organisations. Of 481 patients treated with clozapine for up to 18 weeks, there was documented pretreatment screening of blood pressure, heart rate and ECG in at least 90%, and body weight, plasma lipids, plasma glucose/glycated haemoglobin (HbA1c) and physical examination in approximately 80%. During the first 2 weeks of clozapine treatment there was documented daily measurement of both heart rate and blood pressure in 82% and body temperature in 77%. In a subsample of 411 patients, of the 72% who had weekly side-effect assessments documented in the first month of treatment, a structured assessment tool had been used in 29%. Treatment monitoring up to 18 weeks included an ECG in 90%, C-reactive protein (CRP) or creatine kinase in 42%, and troponin or B-type natriuretic peptide (BNP) in 29%. In the 5908 patients prescribed clozapine for at least 1 year, blood pressure and body weight/body mass index were documented in at least 80%, plasma lipids in 78% and plasma glucose in 73%, with an ECG in 55%. Two-thirds were prescribed medication to manage side effects of clozapine and one third of those with a diagnosis of schizophrenia were prescribed a second antipsychotic medication.
   Conclusion: The findings suggest that for most patients treated with clozapine in UK mental health services, physical health screening and side-effect monitoring follow recommended practice, but there was limited use of structured side-effect assessment tools. Monitoring for clozapine-induced myocarditis during the early risk period using markers of inflammation such as CRP, and cardiac damage such as troponin and BNP, was less consistent. This may partly reflect the variation in guideline recommendations for monitoring for myocarditis and partly the selected use of such tests when prompted by cardiac symptoms. The relatively common coprescription of medications for the majority of people on longer-term clozapine treatment may well further increase side-effect burden and physical health risks, reinforcing the need for continuing systematic monitoring.
C1 [Barnes, Thomas R. E.; Paton, Carol] Imperial Coll London, Div Psychiat, 7th Floor Commonwealth Bldg,Du Cane Rd, London W12 0NN, England.
   [MacCabe, James H.] Kings Coll London, Inst Psychiat Psychol & Neurosci, London, England.
   [MacCabe, James H.] NIHR Biomed Res Ctr Mental Hlth, South London, England.
   [MacCabe, James H.] Maudsley NHS Fdn Trust, London, England.
   [Kane, John M.] Zucker Hillside Hosp, Dept Psychiat, New York, NY USA.
   [Delgado, Oriana; Paton, Carol] Royal Coll Psychiatrists, Ctr Qual Improvement, Prescribing Observ Mental Hlth, London, England.
C3 Imperial College London; University of London; King's College London;
   South London & Maudsley NHS Trust; Northwell Health
RP Barnes, TRE (corresponding author), Imperial Coll London, Div Psychiat, 7th Floor Commonwealth Bldg,Du Cane Rd, London W12 0NN, England.
EM t.r.barnes@imperial.ac.uk
RI Kane, Jeremy/JTU-1481-2023; Barnes, Thomas/KJC-1245-2024; MacCabe,
   James/E-5210-2010
OI MacCabe, James/0000-0002-6754-1018; Kane, John/0000-0002-2628-9442;
   Paton, Carol/0000-0001-7756-1031
FU Lundbeck
FX The authors disclosed receipt of the following financial support for the
   research, authorship, and/or publication of this article: The work of
   POMH-UK is funded wholly by member subscriptions from mental health
   services in the UK. JHM has received research funding from Lundbeck and
   has accepted hospitality from Lundbeck and Saladax Biochemicals.
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NR 51
TC 6
Z9 6
U1 0
U2 11
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 2045-1253
EI 2045-1261
J9 THER ADV PSYCHOPHARM
JI Ther. Adv. Psychopharm.
PD AUG
PY 2020
VL 10
AR 2045125320937908
DI 10.1177/2045125320937908
PG 10
WC Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Psychiatry
GA NC1RY
UT WOS:000560992700001
PM 32821377
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Miller, JL
   Linville, TD
   Dykens, EM
AF Miller, Jennifer L.
   Linville, Tiffany D.
   Dykens, Elisabeth M.
TI Effects of metformin in children and adolescents with Prader-Willi
   syndrome and early-onset morbid obesity: a pilot study
SO JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
LA English
DT Article
DE metformin; obesity; Prader-Willi syndrome
ID INSULIN SENSITIVITY; SYNDROME PWS; METABOLIC SYNDROME; BRAIN; BODY;
   HYPERPHAGIA; RESISTANCE; CIRCUITRY; GHRELIN; HUNGER
AB Prader-Willi syndrome (PWS) is one of the most commonly recognized causes of early-onset childhood obesity. Individuals with PWS have significant hyperphagia and decreased recognition of satiety. The exact etiology of the hyperphagia remains unknown and, therefore, untreatable. We conducted a pilot, open-label study of response to metformin in 21 children with PWS and six with early morbid obesity (EMO). Participants had significant insulin resistance and glucose intolerance on oral glucose tolerance testing (OGTT) and were started on metformin for these biochemical findings. We administered the Hyperphagia Questionnaire to parents of patients before and after starting metformin treatment. Both the PWS and EMO groups showed significant improvements in food-related distress, anxiety, and ability to be redirected away from food on the Hyperphagia Questionnaire. In the PWS group, improvements were predominantly seen in females. Within the PWS group, responders to metformin had higher 2-h glucose levels on OGTT (7.48 mmol/L vs. 4.235 mmol/L; p=0.003) and higher fasting insulin levels (116 pmol/L vs. 53.5 pmol/L; p=0.04). Additionally, parents of 5/13 individuals with PWS and 5/6 with EMO reported that their child was able to feel full while on metformin (for many this was the first time they had ever described a feeling of fullness). Metformin may improve sense of satiety and decrease anxiety about food in some individuals with PWS and EMO. Positive response to metformin may depend on the degree of hyperinsulinism and glucose intolerance. Nonetheless, the results of this pilot study bear further investigation.
C1 [Miller, Jennifer L.] Univ Florida, Dept Pediat, Div Endocrinol, Gainesville, FL 32610 USA.
   [Linville, Tiffany D.] Univ Florida, Dept Pediat, Gainesville, FL USA.
   [Dykens, Elisabeth M.] Vanderbilt Univ, Dept Psychol, Nashville, TN 37240 USA.
C3 State University System of Florida; University of Florida; State
   University System of Florida; University of Florida; Vanderbilt
   University
RP Miller, JL (corresponding author), Univ Florida, Dept Pediat, Div Endocrinol, Gainesville, FL 32610 USA.
EM millejl@peds.ufl.edu
FU NIDDK NIH HHS [K23 DK081203] Funding Source: Medline
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NR 44
TC 27
Z9 29
U1 0
U2 24
PU WALTER DE GRUYTER GMBH
PI BERLIN
PA GENTHINER STRASSE 13, D-10785 BERLIN, GERMANY
SN 0334-018X
EI 2191-0251
J9 J PEDIATR ENDOCR MET
JI J. Pediatr. Endocrinol. Metab.
PD JAN
PY 2014
VL 27
IS 1-2
BP 23
EP 29
DI 10.1515/jpem-2013-0116
PG 7
WC Endocrinology & Metabolism; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Pediatrics
GA 296EW
UT WOS:000330168900006
PM 23893676
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Melo, MCA
   Garcia, RF
   de Araújo, CFC
   Rangel, DM
   de Bruin, PFC
   de Bruin, VMS
AF Aguiar Melo, Matias Carvalho
   Garcia, Raquel Fernandes
   Cardeal de Araujo, Carolina Freitas
   Rangel, Deborah Moreira
   Carvalhedo de Bruin, Pedro Felipe
   Sales de Bruin, Veralice Meireles
TI Physical activity as prognostic factor for bipolar disorder: An 18-month
   prospective study
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Physical activity; Bipolar disorder; Euthymia; Prognosis
ID MAJOR DEPRESSIVE DISORDER; QUALITY-OF-LIFE; METABOLIC SYNDROME;
   SEDENTARY BEHAVIOR; MENTAL-DISORDERS; ITALIAN PATIENTS; SLEEP QUALITY;
   EXERCISE; PEOPLE; SCHIZOPHRENIA
AB Introduction. Exercise is an adjuvant therapy indicated for various psychiatric disorders. However, prospective studies in patients with bipolar disorder (BD) are scarce and with uncertain conclusions. This study aims to evaluate physical activity as a prognostic factor for BD, analyzing relationship with levels of anxiety, functionality, sleep, mood episodes and hospitalizations. Methods. Three psychiatrists interviewed 80 BD outpatients in euthymia, referred from four different institutions in Brazil. In this moment, they evaluated the intensity of physical activities using the International Physical Activity Questionnaire (IPAQ) - short form. They reevaluated patients and reviewed medical records monthly for 18 months to identify mood episodes and psychiatric hospitalizations. Results. Thirty-eight patients (47.5%) were physically inactive (or sedentary) and 42 (52.5%) active. Physically active patients had lower Body Mass Index (p=0.006), waist circumference (p=0.002), lower levels of anxiety (p=0.032) and less insomnia (p=0.001). Sedentary individuals revealed poorer global functioning (p<0.001) and in all domains: autonomy (p<0.001), occupational functioning (p=0.008), cognitive functioning (p=0.013), capacity of managing the finances (p=0.012), interpersonal relationships (p=0.011) and leisure time (p=0.001). Less activity was associated with more mood episodes (p=0.042) and psychiatric hospitalizations (p=0.043) over 18 months. Conclusion. This study suggested physical activity as a good prognostic factor for BD during euthymia. This reinforces the need to encourage this practice in clinical settings. Future prospective surveys with longer duration using objective instruments are proposed.
C1 [Aguiar Melo, Matias Carvalho; Carvalhedo de Bruin, Pedro Felipe; Sales de Bruin, Veralice Meireles] Univ Fed Ceara, Dept Med Sci, Av Sargento Herminio 880,Quadra A Bloco 5 Ap 201, Fortaleza, Ceara, Brazil.
   [Aguiar Melo, Matias Carvalho; Garcia, Raquel Fernandes; Cardeal de Araujo, Carolina Freitas; Rangel, Deborah Moreira] Hosp Saude Mental Prof Frota Pinto, Fortaleza, Ceara, Brazil.
   [Aguiar Melo, Matias Carvalho] Univ Fortaleza, Fortaleza, Ceara, Brazil.
C3 Universidade Federal do Ceara; Universidade Fortaleza
RP Melo, MCA (corresponding author), Univ Fed Ceara, Dept Med Sci, Av Sargento Herminio 880,Quadra A Bloco 5 Ap 201, Fortaleza, Ceara, Brazil.
EM matcarv01@yahoo.com.br
RI Melo, Matias/Z-6094-2019; CARVALHEDO DE BRUIN, PEDRO FELIPE/C-6056-2016
OI CARVALHEDO DE BRUIN, PEDRO FELIPE/0000-0001-9694-1523; Melo,
   Matias/0000-0002-3195-6852
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NR 64
TC 17
Z9 17
U1 0
U2 11
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD MAY 15
PY 2019
VL 251
BP 100
EP 106
DI 10.1016/j.jad.2019.03.061
PG 7
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA HU7AP
UT WOS:000465433800014
PM 30921592
DA 2025-06-11
ER

PT J
AU Monroe, EJ
   Hardy, R
   Holmquist, J
   Brand, JC
AF Monroe, Emily J.
   Hardy, Richard
   Holmquist, James
   Brand, Jefferson C.
TI Obesity and Reverse Total Shoulder Arthroplasty
SO CURRENT REVIEWS IN MUSCULOSKELETAL MEDICINE
LA English
DT Article
DE Obesity; Reverse total shoulder arthroplasty; Rotator cuff
ID BODY-MASS INDEX; CARDIOVASCULAR-DISEASE; RISK-FACTORS; OUTCOMES;
   COMPLICATIONS; ASSOCIATION; ANXIETY; SYMPTOMS; DATABASE; BMI
AB Purpose of Review Rates of obesity and reverse total shoulder arthroplasty (rTSA) in the USA have both escalated with time. Obese patients experience arthritis at higher rates than normal weight patients; therefore, these numbers go hand in hand. Obesity has been correlated with health comorbidities such as anxiety, cardiovascular disease, diabetes, and metabolic syndrome as well as poorer outcomes and higher complication rates following lower extremity arthroplasty. The current review investigates these comorbidities as they relate to obese patients undergoing rTSA. Recent Findings Functional outcomes are similar to normal weight counterparts. Although longer operative times and a large soft tissue envelope would intuitively predispose these patients to higher risk for infection or other complications, this has not been reliably demonstrated. Technical considerations and awareness of potential risks in the obese patient demographic may aid the surgeon in preoperative planning and counseling of their patient. Obese patients undergoing rTSA have been shown to have higher risks specifically for infection, revision, and medical complications; however, this has not been consistently demonstrated in the single surgeon series where, more often, no difference in these metrics has been found. Outcomes measures and satisfaction are reliably improved, even when considering superobese patients, and majority of studies find their improvements and absolute values to be in line with their normal weight counterparts. Thus, rTSA does not seem to carry the same level of adverse risk associated with lower joint arthroplasty but potential for higher risk still bears consideration when counseling obese patients. Attention to factors that may negatively affect prosthesis positioning may optimize retention rates and limit early failure.
C1 [Monroe, Emily J.; Hardy, Richard; Holmquist, James; Brand, Jefferson C.] Heartland Orthoped Specialists, 111 17th Ave E,Ste 101, Alexandria, MN 56308 USA.
RP Monroe, EJ (corresponding author), Heartland Orthoped Specialists, 111 17th Ave E,Ste 101, Alexandria, MN 56308 USA.
EM emonroe@heartlandorthopedics.com; hardyr@morris.umn.edu;
   holmq090@umn.edu; jbrand@heartlandorthopedics.com
RI Brand, Jefferson/HAA-8515-2022
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NR 52
TC 7
Z9 7
U1 0
U2 1
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1935-973X
EI 1935-9748
J9 CURR REV MUSCULOSKE
JI Curr. Rev. Musculoskelet. Med.
PD JUN
PY 2022
VL 15
IS 3
BP 180
EP 186
DI 10.1007/s12178-022-09753-8
EA MAY 2022
PG 7
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA 1G7TV
UT WOS:000791076400001
PM 35511332
OA Green Published
DA 2025-06-11
ER

PT J
AU Sousa, JN
   Sousa, BVD
   dos Santos, EP
   Ribeiro, GHM
   Pereira, APM
   Guimaraes, VHD
   Queiroz, LDP
   Motta-Santos, D
   Farias, LC
   Guimaraes, ALS
   de Paula, AMB
   Santos, SHS
AF Sousa, Jaciara Neves
   de Oliveira Sousa, Berenilde Valeria
   dos Santos, Eduardo Pinheiro
   Mendes Ribeiro, Guilherme Henrique
   Maciel Pereira, Ana Paula
   Dantas Guimaraes, Victor Hugo
   Pereira Queiroz, Lorena dos Reis
   Motta-Santos, Daisy
   Farias, Lucyana Conceica
   Sena Guimaraes, Andre Luiz
   Batista de Paula, Alfredo Mauricio
   Sousa Santos, Sergio Henrique
TI Effects of gallic acid and physical training on liver damage, force, and
   anxiety in obese mice: Hepatic modulation of Sestrin 2 (SESN2) and PGC-
   α expression
SO GENE
LA English
DT Article
DE Sestrin 2; Gallic acid; Obesity; Physical training; Animal model;
   Exercise
ID SKELETAL-MUSCLE; METABOLIC SYNDROME; GRIP STRENGTH; EXERCISE; WEIGHT;
   INFLAMMATION; COMPONENTS; RESISTANCE; OVERWEIGHT; TOXICITY
AB Obesity and overweight are multifactorial diseases affecting more than one-third of the world ' s population. Physical inactivity contributes to a positive energy balance and the onset of obesity. Exercise combined with a balanced diet is an effective non-pharmacological strategy to improve obesity-related disorders. Gallic acid (GA), is a natural endogenous polyphenol found in a variety of fruits, vegetables, and wines, with beneficial effects on energetic homeostasis. The present study aims to investigate the effects of exercise training on obese mice supplemented with GA. Animal experimentation was performed with male Swiss mice divided into five groups: ST (standard control), HFD (obese control), HFD + GA (GA supplement), HFD + Trained (training), and HFD + GA + Trained (GA and training). The groups are treated for eight weeks with 200 mg/kg/body weight of the feed compound and, if applicable, physical training. The main findings of the present study show that GA supplementation improves liver fat, body weight, adiposity, and plasma insulin levels. In addition, animals treated with the GA and a physical training program demonstrate reduced levels of anxiety. Gene expression analyses show that Sesn2 is activated via PGC-1 alpha independent of the GATOR2 protein, which is activated by GA in the context of physical activity. These data are corroborated by molecular docking analysis, demonstrating the interaction of GA with GATOR2. The present study contributes to understanding the metabolic effects of GA and physical training and demonstrates a new hepatic mechanism of action via Sestrin 2 and PGC-1 alpha .
C1 [Sousa, Jaciara Neves; de Oliveira Sousa, Berenilde Valeria; dos Santos, Eduardo Pinheiro; Mendes Ribeiro, Guilherme Henrique; Maciel Pereira, Ana Paula; Dantas Guimaraes, Victor Hugo; Pereira Queiroz, Lorena dos Reis; Farias, Lucyana Conceica; Sena Guimaraes, Andre Luiz; Batista de Paula, Alfredo Mauricio; Sousa Santos, Sergio Henrique] Univ Estadual Montes Claros Unimontes, Post Grad Program Hlth Sci, Lab Hlth Sci, Montes Claros, MG, Brazil.
   [Mendes Ribeiro, Guilherme Henrique; Maciel Pereira, Ana Paula; Sousa Santos, Sergio Henrique] Univ Fed Minas Gerais UFMG, Inst Agr Sci ICA, Post Grad Program Food & Hlth, Montes Claros, MG, Brazil.
   [Motta-Santos, Daisy] Univ Fed Minas Gerais, Sports Dept, Belo Horizonte, MG, Brazil.
C3 Universidade Estadual de Montes Claros; Universidade Federal de Minas
   Gerais
RP Santos, SHS (corresponding author), Univ Fed Minas Gerais UFMG, Food Engn Coll, Inst Agr Sci ICA, Avenida Univ1 000,,Univ, BR-39 40454 Montes Claros, MG, Brazil.
EM sergiosousas@hotmail.com
RI Pereira, Ana/AAK-4584-2020; Santos, Sérgio/D-8143-2011; De Paula,
   Alfredo/K-3015-2012; Queiroz, Lorena/AAA-9494-2020; Motta-Santos,
   Daisy/A-9191-2010; Henrique Mendes Ribeiro, Guilherme/JMC-9043-2023;
   Guimarães, Victor/AGJ-6023-2022
FU Coordenadoria de Aperfeicoamento do Pessoal de Nivel Superior (CAPES);
   Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq);
   Fundacao de Amparo a Pesquisa do Estado de Minas Gerais (FAPEMIG)
FX This work was partially supported by the Coordenadoria de
   Aperfeicoamento do Pessoal de Nivel Superior (CAPES) and Conselho
   Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) and Fundacao
   de Amparo a Pesquisa do Estado de Minas Gerais (FAPEMIG).
CR Abreu C.D.D., 2022, Inulin prebiotic dietary supplementation improves metabolic parameters by reducing the Toll-like receptor 4 transmembrane protein gene and interleukin 6 expression in adipose
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NR 90
TC 5
Z9 5
U1 1
U2 2
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0378-1119
EI 1879-0038
J9 GENE
JI Gene
PD OCT 30
PY 2024
VL 926
AR 148606
DI 10.1016/j.gene.2024.148606
EA JUN 2024
PG 12
WC Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Genetics & Heredity
GA UZ2D8
UT WOS:001251813100001
PM 38788813
DA 2025-06-11
ER

PT J
AU John, U
   Meyer, C
   Rumpf, HJ
   Hapke, U
AF John, U
   Meyer, C
   Rumpf, HJ
   Hapke, U
TI Relationships of psychiatric disorders with overweight and obesity in an
   adult general population
SO OBESITY RESEARCH
LA English
DT Article
DE smoking; nicotine dependence; alcohol risk drinking; alcohol use
   disorders; weight gain
ID INTERNATIONAL DIAGNOSTIC INTERVIEW; BODY-MASS INDEX; WEIGHT-GAIN;
   NICOTINE DEPENDENCE; METABOLIC SYNDROME; MOOD DISORDERS; GERMAN TACOS;
   RISK-FACTORS; SMOKING; ALCOHOL
AB Objective: To explore relationships of smoking and risk drinking status, nicotine and alcohol dependence, and anxiety, depressive, and somatoform disorders with overweight and obesity.
   Research Methods and Procedures: A probability sample was drawn that was representative for the adult general population, 18 to 64 years of age, in one region of Germany; the participation rate was 70.2%. After excluding those who were pregnant or had a current eating disorder according to the DSM-IV, 4063 individuals remained. Overweight and obesity were defined according to the BMI that was assessed in the face-to-face in-home standardized interview (Composite International Diagnostic Interview) on psychiatric disorders.
   Results: Men with a former nicotine dependence had higher odds of being overweight than men who never had a nicotine dependence (adjusted odds ratio, 1.5; confidence interval, 1.1 to 2.1). Men at current risk for drinking and current alcohol-dependent or abusing men had lower odds of being overweight compared with men who never were alcohol dependent, abusing, or at risk for drinking (adjusted odds ratio, 0.3; confidence interval, 0.8 to 0.9). Effect sizes were small. No relationship of overweight with depressive, anxiety, or somatoform disorders was found in the multivariate analysis.
   Discussion: There is a relationship between being overweight and nicotine and alcohol dependence or abuse among men but not among womed. Even though one reason for women to refrain from quitting smoking is the fear of weight gain, these results do not support this. This information could help convince women to try to quit smoking.
C1 Ernst Moritz Arndt Univ Greifswald, Inst Epidemiol & Social Med, D-17487 Greifswald, Germany.
   Univ Lubeck, Res Grp S TEP, Dept Psychiat & Psychotherapy, Lubeck, Germany.
C3 Universitat Greifswald; University of Lubeck
RP John, U (corresponding author), Ernst Moritz Arndt Univ Greifswald, Inst Epidemiol & Social Med, Walther Rathenau Str 48, D-17487 Greifswald, Germany.
EM ujohn@uni-greifswald.de
RI Rumpf, Hans-Jürgen/ABD-3478-2020; Meyer, Christian/G-7448-2011
OI John, Ulrich/0000-0003-0587-5298; Rumpf,
   Hans-Juergen/0000-0001-6848-920X; Meyer, Christian/0000-0003-4722-7109
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NR 30
TC 74
Z9 84
U1 0
U2 10
PU NORTH AMER ASSOC STUDY OBESITY
PI SILVER SPRING
PA 8630 FENTON ST, SUITE 918, SILVER SPRING, MD 20910 USA
SN 1071-7323
J9 OBES RES
JI Obes. Res.
PD JAN
PY 2005
VL 13
IS 1
BP 101
EP 109
DI 10.1038/oby.2005.13
PG 9
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 907BG
UT WOS:000227689200013
PM 15761168
OA Bronze
DA 2025-06-11
ER

PT J
AU Dasari, SS
   Archer, M
   Mohamed, NE
   Tewari, AK
   Figueiro, MG
   Kyprianou, N
AF Dasari, Sonali S.
   Archer, Maddison
   Mohamed, Nihal E.
   Tewari, Ashutosh K.
   Figueiro, Mariana G.
   Kyprianou, Natasha
TI Circadian Rhythm Disruption as a Contributor to Racial Disparities in
   Prostate Cancer
SO CANCERS
LA English
DT Review
DE racial disparities; prostate cancer; circadian genes; night shift work;
   artificial light at night; jet lag; obesity; stress; melatonin;
   treatment resistance
ID NIGHT-SHIFT WORK; GLUCOCORTICOID-RECEPTOR; ARTIFICIAL-LIGHT; HEALTH
   CONSEQUENCES; METABOLIC SYNDROME; SLEEP DISRUPTION; BREAST-CANCER;
   RADICAL PROSTATECTOMY; RETROSPECTIVE COHORT; SOCIOECONOMIC-STATUS
AB Simple Summary African American (AA) men have 2.4 times higher mortality rate due to prostate cancer than White men in the United States. Evidence implicates circadian rhythm disruption (CRD) as a potential driver of prostate cancer risk and progression. AA men are particularly vulnerable to CRDs due to greater exposure to night shift work, artificial light at night, noise pollution, racial discrimination, and socioeconomic disadvantages. In this review, we discuss the growing contribution of CRDs to the racial disparities associated with the incidence, aggressiveness, and progression of prostate cancer and highlight the unmet clinical need of integrating circadian-related therapies to enhance current prostate cancer treatment modalities. In the United States, African American (AA) men have a 2.4 times higher mortality rate due to prostate cancer than White men. The multifactorial causes of the racial disparities in prostate cancer involve various social determinants of health, socioeconomic status, and access to healthcare. However, emerging evidence also suggests that circadian rhythm disruption (CRD) contributes to prostate cancer, and AA men may be more susceptible to developing CRDs. Circadian rhythms play a significant role in metabolism, hormone secretion, and sleep/wake cycles. Disruption in these circadian rhythms can be caused by airplane travel/jetlag, night shift work, exposure to light, and neighborhood noise levels, which can contribute to sleep disorders and chronic conditions such as obesity, diabetes, cardiovascular disease, and depression. The drivers of the racial disparities in CRD include night shift work, racial discrimination, elevated stress, and residing in poor neighborhoods characterized by high noise pollution. Given the increased vulnerability of AA men to CRDs, and the role that CRDs play in prostate cancer, elucidating the clock-related prostate cancer pathways and their behavior and environmental covariates may be critical to better understanding and reducing the racial disparities in prostate cancer.
C1 [Dasari, Sonali S.; Archer, Maddison; Mohamed, Nihal E.; Tewari, Ashutosh K.; Kyprianou, Natasha] Icahn Sch Med Mt Sinai, Dept Urol, New York, NY 10029 USA.
   [Mohamed, Nihal E.; Tewari, Ashutosh K.; Figueiro, Mariana G.; Kyprianou, Natasha] Mt Sinai Hlth, Tisch Canc Inst, New York, NY 10029 USA.
   [Tewari, Ashutosh K.; Kyprianou, Natasha] Icahn Sch Med Mt Sinai, Dept Oncol Sci, New York, NY 10029 USA.
   [Figueiro, Mariana G.] Icahn Sch Med Mt Sinai, Light & Hlth Res Ctr, Dept Populat Hlth Sci & Policy, New York, NY 10029 USA.
C3 Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at
   Mount Sinai; Icahn School of Medicine at Mount Sinai
RP Kyprianou, N (corresponding author), Icahn Sch Med Mt Sinai, Dept Urol, New York, NY 10029 USA.; Figueiro, MG; Kyprianou, N (corresponding author), Mt Sinai Hlth, Tisch Canc Inst, New York, NY 10029 USA.; Kyprianou, N (corresponding author), Icahn Sch Med Mt Sinai, Dept Oncol Sci, New York, NY 10029 USA.; Figueiro, MG (corresponding author), Icahn Sch Med Mt Sinai, Light & Hlth Res Ctr, Dept Populat Hlth Sci & Policy, New York, NY 10029 USA.
EM mariana.figueiro@mountsinai.org; natasha.kyprianou@mountsinai.org
RI Figueiro, Mariana/A-1631-2014
OI Kyprianou, Natasha/0000-0002-8713-3599; Dasari,
   Sonali/0000-0002-5928-4584; Archer, Maddison/0000-0002-2755-2521
FU National Institutes of Health/NCI [R01 CA232574]; NIH/NIOSH
   [R01OH01668]; Deane Prostate Health and The Arthur M. Blank Family
   Foundation; Department of Defense [W81XWH-17-1-0590, PC160194]; National
   Institute of Nursing Research [(1R21 NR0165)18-01A1]
FX This work was supported by the following funding: Grant #R01
   CA232574/National Institutes of Health/NCI (NK); Grant
   #R01OH01668/NIH/NIOSH (MGF); the Deane Prostate Health and The Arthur M.
   Blank Family Foundation (AKT); Department of Defense W81XWH-17-1-0590
   #PC160194 and the National Institute of Nursing Research (1R21
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NR 172
TC 11
Z9 11
U1 1
U2 8
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6694
J9 CANCERS
JI Cancers
PD OCT
PY 2022
VL 14
IS 20
AR 5116
DI 10.3390/cancers14205116
PG 19
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA 5O5SA
UT WOS:000872531700001
PM 36291899
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Saarni, SE
   Saarni, SI
   Fogelholm, M
   Heliövaara, M
   Perälä, J
   Suvisaari, J
   Lönnqvist, J
AF Saarni, S. E.
   Saarni, S. I.
   Fogelholm, M.
   Heliovaara, M.
   Perala, J.
   Suvisaari, J.
   Lonnqvist, J.
TI Body composition in psychotic disorders: a general population survey
SO PSYCHOLOGICAL MEDICINE
LA English
DT Article
DE Abdominal obesity; bioimpedance; mental disorder; obesity; schizophrenia
ID CATIE SCHIZOPHRENIA TRIAL; CORONARY-HEART-DISEASE; MIDDLE-AGED MEN;
   METABOLIC SYNDROME; ATYPICAL ANTIPSYCHOTICS; WAIST CIRCUMFERENCE;
   INSULIN-RESISTANCE; HIGH PREVALENCE; UNITED-STATES; DRUG-NAIVE
AB Background. The literature suggests an association between obesity and schizophrenia but fat mass and fat-free mass, which have been shown to be more predictive of all-cause mortality than only waist circumference and obesity [body mass index (BMI) >= 30 kg/m(2)] have not been reported in psychotic disorders. We examined the detailed body composition of people with different psychotic disorders in a large population-based sample.
   Method. We used a nationally representative sample of 8082 adult Firms aged >= 30 years with measured anthropometrics (height, weight, waist Circumference, fat percentage, fat-free mass and segmental muscle mass). Psychiatric diagnoses were based on a consensus procedure utilizing the Structured Clinical Interview for DSM-IV (SCID)-interview, case-notes and comprehensive register data.
   Results. Schizophrenia (including schizo-affective disorder) was associated with obesity [odds ratio (OR) 2.3, 95%, confidence interval (CI) 1.5-3.6], abdominal obesity (waist circumference >= 88 cm for women, >= 102 cm for men) (OR 2.2, 95% CI 1.3-3.6) and with higher fat percentage (mean difference 3.8%, 95%, CI 2.0-5.7%), adjusted for age and gender, than in the remaining sample. The associations between schizophrenia and low fat-free mass and decreased muscle mass on trunk and upper limbs became statistically significant after adjusting for BMI. After further adjusting for Current antipsychotic medication, education, diet and smoking, schizophrenia remained associated with obesity (OR 1.9, 95% CI 1.1-3.6) and abdominal obesity (OR 3.8, 95% CI 1.5-9.4). Participants with affective psychoses did not differ from the general population.
   Conclusions. Individuals with schizophrenia have metabolically unfavorable body composition, comprising abdominal obesity, high fat percentage and low muscle mass. This leads to increased risk of metabolic and cardiovascular diseases.
C1 [Saarni, S. E.] Univ Helsinki, Dept Publ Hlth, FIN-00014 Helsinki, Finland.
   [Saarni, S. E.; Saarni, S. I.; Heliovaara, M.; Perala, J.; Suvisaari, J.; Lonnqvist, J.] Natl Publ Hlth Inst, Dept Mental Hlth & Alcohol Res, SF-00300 Helsinki, Finland.
   [Fogelholm, M.] UKK Inst Hlth Promot Res, Tampere, Finland.
   [Fogelholm, M.] Pirkanmaa Hosp Dist, Res Unit, Tampere, Finland.
   [Lonnqvist, J.] Univ Helsinki, Cent Hosp, FIN-00014 Helsinki, Finland.
   [Lonnqvist, J.] Univ Helsinki, Dept Psychiat, FIN-00014 Helsinki, Finland.
C3 University of Helsinki; Finland National Institute for Health & Welfare;
   UKK Institute; Pirkanmaa Hospital District; University of Helsinki;
   Helsinki University Central Hospital; University of Helsinki
RP Saarni, SE (corresponding author), Univ Helsinki, Dept Publ Hlth, POB 41, FIN-00014 Helsinki, Finland.
EM suoma.saarni@helsinki.fi
RI Saarni, Suoma/AFZ-4971-2022
OI Suvisaari, Jaana/0000-0001-7167-0990; Fogelholm,
   Mikael/0000-0001-8110-102X; Saarni, Suoma Eeva/0000-0003-3555-9958
FU Foundation for Psychiatric Research; Gyllenberg Foundation; Stanley
   Medical Research Institute; Academy of Finland; Yrjo Jahnsson Foundation
FX This Study was supported by, grants from the Foundation for Psychiatric
   Research (S. E. S.) and the Gyllenberg Foundation (S.E.S.), the Stanley
   Medical Research Institute (J.S.), the Academy of Finland (J.L.) and the
   Yrjo Jahnsson Foundation (J.S.). The funding sources listed above had no
   involvement.
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NR 59
TC 52
Z9 53
U1 0
U2 19
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
SN 0033-2917
EI 1469-8978
J9 PSYCHOL MED
JI Psychol. Med.
PD MAY
PY 2009
VL 39
IS 5
BP 801
EP 810
DI 10.1017/S0033291708004194
PG 10
WC Psychology, Clinical; Psychiatry; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA 438QA
UT WOS:000265569200012
PM 18713488
DA 2025-06-11
ER

PT J
AU Forcina, G
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AF Forcina, Gianmario
   Luciano, Margherita
   Frattolillo, Vittoria
   Mori, Simona
   Monaco, Noemi
   Guarino, Stefano
   Marzuillo, Pierluigi
   Miraglia del Giudice, Emanuele
   Di Sessa, Anna
TI Kidney Damage in Pediatric Obesity: Insights from an Emerging
   Perspective
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Article
DE kidney damage; children; obesity; cardiometabolic risk; management
ID METABOLICALLY HEALTHY; DISEASE; CHILDREN; RISK; EPIDEMIOLOGY;
   ADOLESCENTS
AB The role of obesity as a risk factor for chronic kidney disease (CKD) in adulthood has been well established. Over the last years, kidney damage (KD) has emerged as a significant consequence of obesity since childhood. Indeed, a complex interplay of metabolic factors, including insulin resistance (IR), hypertension, oxidative stress, adipose tissue dysfunction, and systemic inflammation, might affect renal hemodynamics, contributing to CKD development over time in at-risk young patients. As the prevalence of pediatric obesity continues to rise globally, understanding the implications for kidney health in terms of early intervention is of paramount importance. Careful monitoring of kidney function within a multidisciplinary approach in children with obesity is crucial for detecting early KD, allowing for timely lifestyle modifications and treatment. In this framework, continued research is essential to further elucidate mechanisms linking obesity and KD and to explore not only effective preventive strategies but also the long-term impact of obesity on kidney health in children with obesity. Given the intimate link of KD with the metabolic milieu in children with obesity, we aimed to provide a comprehensive and insightful overview on KD and its implications in pediatric obesity by reviewing the most recent literature in the field.
C1 [Forcina, Gianmario; Luciano, Margherita; Frattolillo, Vittoria; Mori, Simona; Monaco, Noemi; Guarino, Stefano; Marzuillo, Pierluigi; Miraglia del Giudice, Emanuele; Di Sessa, Anna] Univ Campania Luigi Vanvitelli, Dept Woman Child & Gen & Specialized Surg, I-80138 Naples, Italy.
C3 Universita della Campania Vanvitelli
RP Marzuillo, P (corresponding author), Univ Campania Luigi Vanvitelli, Dept Woman Child & Gen & Specialized Surg, I-80138 Naples, Italy.
EM gianmario.forcina@gmail.com; margherita.luciano2@gmail.com;
   vitto.fratt@gmail.com; esse.mori@gmail.com; monaconoemi1@gmail.com;
   stefano.guarino@policliniconapoli.it;
   pierluigi.marzuillo@unicampania.it; emanuele.miraglia@unicampania.it;
   anna.disessa@unicampania.it
RI DI SESSA, ANNA/K-3831-2018; Marzuillo, Pierluigi/J-7447-2018
OI Frattolillo, Vittoria/0009-0007-2288-343X; di sessa,
   anna/0000-0002-5877-3757; Forcina, Gianmario/0009-0007-0385-2734;
   Marzuillo, Pierluigi/0000-0003-4682-0170
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NR 66
TC 2
Z9 2
U1 1
U2 1
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD DEC
PY 2024
VL 13
IS 23
AR 7025
DI 10.3390/jcm13237025
PG 13
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA P2U8A
UT WOS:001376532100001
PM 39685484
OA gold
DA 2025-06-11
ER

PT J
AU Shah, MT
   Inacio, MD
   Lu, C
   Schiratti, PR
   Zheng, SL
   Clement, A
   de Marvao, A
   Bai, WJ
   King, AP
   Ware, JS
   Wilkins, MR
   Mielke, J
   Elci, E
   Kryukov, I
   McGurk, KA
   Bender, C
   Freitag, DF
   O'Regan, DP
AF Shah, Mit
   Inacio, Marco de A. H.
   Lu, Chang
   Schiratti, Pierre-Raphael
   Zheng, Sean L. L.
   Clement, Adam
   de Marvao, Antonio
   Bai, Wenjia
   King, Andrew P.
   Ware, James S.
   Wilkins, Martin R.
   Mielke, Johanna
   Elci, Eren
   Kryukov, Ivan
   McGurk, Kathryn A.
   Bender, Christian
   Freitag, Daniel F.
   O'Regan, Declan P.
TI Environmental and genetic predictors of human cardiovascular ageing
SO NATURE COMMUNICATIONS
LA English
DT Article
ID ARTERIAL STIFFNESS; BLOOD-PRESSURE; HEART; PARTICIPANTS; BRAIN; AGE
AB Cardiovascular ageing is a process that begins early in life and leads to a progressive change in structure and decline in function due to accumulated damage across diverse cell types, tissues and organs contributing to multi-morbidity. Damaging biophysical, metabolic and immunological factors exceed endogenous repair mechanisms resulting in a pro-fibrotic state, cellular senescence and end-organ damage, however the genetic architecture of cardiovascular ageing is not known. Here we use machine learning approaches to quantify cardiovascular age from image-derived traits of vascular function, cardiac motion and myocardial fibrosis, as well as conduction traits from electrocardiograms, in 39,559 participants of UK Biobank. Cardiovascular ageing is found to be significantly associated with common or rare variants in genes regulating sarcomere homeostasis, myocardial immunomodulation, and tissue responses to biophysical stress. Ageing is accelerated by cardiometabolic risk factors and we also identify prescribed medications that are potential modifiers of ageing. Through large-scale modelling of ageing across multiple traits our results reveal insights into the mechanisms driving premature cardiovascular ageing and reveal potential molecular targets to attenuate age-related processes.
   Cardiovascular ageing is characterised by a progressive decline in function, which contributes to multi-morbidity. Here, the authors use machine learning to predict biological age and identify key genetic risk factors.
C1 [Shah, Mit; Inacio, Marco de A. H.; Lu, Chang; Schiratti, Pierre-Raphael; Clement, Adam; de Marvao, Antonio; Ware, James S.; McGurk, Kathryn A.; O'Regan, Declan P.] Imperial Coll London, MRC London Inst Med Sci, London, England.
   [Zheng, Sean L. L.; Ware, James S.; Wilkins, Martin R.; McGurk, Kathryn A.] Imperial Coll London, Natl Heart & Lung Inst, London, England.
   [Bai, Wenjia] Imperial Coll London, Dept Comp, London, England.
   [Bai, Wenjia] Imperial Coll London, Dept Brain Sci, London, England.
   [King, Andrew P.] Kings Coll London, Sch Biomed Engn & Imaging Sci, London, England.
   [Mielke, Johanna; Elci, Eren; Kryukov, Ivan; Bender, Christian; Freitag, Daniel F.] Bayer AG, Res & Dev, Pharmaceut, Wuppertal, Germany.
C3 Imperial College London; Imperial College London; Imperial College
   London; Imperial College London; University of London; King's College
   London; Bayer AG
RP O'Regan, DP (corresponding author), Imperial Coll London, MRC London Inst Med Sci, London, England.
EM declan.oregan@imperial.ac.uk
RI McGurk, Kathryn/AAB-3661-2021; Wilkins, Martin/ABH-1140-2021; Ware,
   James/G-5139-2012; de Marvao, Antonio/JFJ-9840-2023; Bai,
   Wenjia/ABH-6023-2020; Lu, Chang/AAL-3229-2021; Bai, Wenjia/B-3377-2017
OI Schiratti, Pierre-Raphael/0000-0002-6620-4888; de Marvao,
   Antonio/0000-0001-9095-5887; Ware, James/0000-0002-6110-5880; Bai,
   Wenjia/0000-0003-2943-7698; Lu, Chang/0000-0002-3272-0120; McGurk,
   Kathryn/0000-0002-5445-6906; King, Andrew/0000-0002-9965-7015
FU Medical Research Council [MC_UP_1605/13]; National Institute for Health
   Research (NIHR) Imperial College Biomedical Research Centre; British
   Heart Foundation [RG/19/6/34387, RE/18/4/34215]; Sir Jules Thorn
   Charitable Trust [40616]; UK Biobank Resource;  [21JTA];  [28807]
FX D.P.O'R. acknowledges support from Bayer AG, the Medical Research
   Council (MC_UP_1605/13); National Institute for Health Research (NIHR)
   Imperial College Biomedical Research Centre; and the British Heart
   Foundation (RG/19/6/34387, RE/18/4/34215); J.S.W. acknowledges support
   from the Sir Jules Thorn Charitable Trust [21JTA]. This research has
   been conducted using the UK Biobank Resource under Application Numbers
   28807 and 40616. The genetic association analyses were conducted on the
   UK Biobank Research Analysis Platform (https://ukbiobank.dnanexus.com).
   We thank James Cole (UCL) and Tobias Kaufmann (University of Tuebingen)
   for advice on age-delta modelling. We also thank Tim Dawes, Ghalib
   Bello, and Carlo Biffi (Imperial College London) for developing the
   three-dimensional cardiac modelling used in this study. We also
   acknowledge Esther Puyol-Anton, Bram Ruijsink and Reza Razavi for the T1
   mapping data.For the purpose of open access, the authors have applied a
   creative commons attribution (CC BY) licence to any author-accepted
   manu-script version arising.
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NR 78
TC 21
Z9 21
U1 1
U2 15
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
EI 2041-1723
J9 NAT COMMUN
JI Nat. Commun.
PD AUG 21
PY 2023
VL 14
IS 1
AR 4941
DI 10.1038/s41467-023-40566-6
PG 15
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA P9AV6
UT WOS:001053537800022
PM 37604819
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Correia, BSB
   Nani, JV
   Ricardo, RW
   Stanisic, D
   Costa, TBBC
   Hayashi, MAF
   Tasic, L
AF Correia, Banny Silva Barbosa
   Nani, Joao Victor
   Waladares Ricardo, Raniery
   Stanisic, Danijela
   Costa, Tassia Brena Barroso Carneiro
   Hayashi, Mirian A. F.
   Tasic, Ljubica
TI Effects of Psychostimulants and Antipsychotics on Serum Lipids in an
   Animal Model for Schizophrenia
SO BIOMEDICINES
LA English
DT Article
DE lipidomics; schizophrenia; animal models; antipsychotics
ID SPONTANEOUSLY HYPERTENSIVE-RATS; CHOLESTEROL; PLASMA; BRAIN; ACID;
   PHOSPHOLIPIDS; AMPHETAMINE; METABOLISM; ALZHEIMERS; LIPIDOMICS
AB Schizophrenia (SCZ) treatment is essentially limited to the use of typical or atypical antipsychotic drugs, which suppress the main symptoms of this mental disorder. Metabolic syndrome is often reported in patients with SCZ under long-term drug treatment, but little is known about the alteration of lipid metabolism induced by antipsychotic use. In this study, we evaluated the blood serum lipids of a validated animal model for SCZ (Spontaneously Hypertensive Rat, SHR), and a normal control rat strain (Normotensive Wistar Rat, NWR), after long-term treatment (30 days) with typical haloperidol (HAL) or atypical clozapine (CLZ) antipsychotics. Moreover, psychostimulants, amphetamine (AMPH) or lisdexamfetamine (LSDX), were administered to NWR animals aiming to mimic the human first episode of psychosis, and the effects on serum lipids were also evaluated. Discrepancies in lipids between SHR and NWR animals, which included increased total lipids and decreased phospholipids in SHR compared with NWR, were similar to the differences previously reported for SCZ patients relative to healthy controls. Administration of psychostimulants in NWR decreased omega-3, which was also decreased in the first episode of psychosis of SCZ. Moreover, choline glycerophospholipids allowed us to distinguish the effects of CLZ in SHR. Thus, changes in the lipid metabolism in SHR seem to be reversed by the long-term treatment with the atypical antipsychotic CLZ, which was under the same condition described to reverse the SCZ-like endophenotypes of this validated animal model for SCZ. These data open new insights for understanding the potential influence of the treatment with typical or atypical antipsychotics on circulating lipids. This may represent an outcome effect from metabolic pathways that regulate lipids synthesis and breakdown, which may be reflecting a cell lipids dysfunction in SCZ.
C1 [Correia, Banny Silva Barbosa; Waladares Ricardo, Raniery; Stanisic, Danijela; Costa, Tassia Brena Barroso Carneiro; Tasic, Ljubica] Univ Estadual Campinas UNICAMP, Inst Quim, BR-13083970 Campinas, Brazil.
   [Nani, Joao Victor; Hayashi, Mirian A. F.] Univ Fed Sao Paulo UNIFESP, Escola Paulista Med EPM, Dept Farmacol, BR-04044020 Sao Paulo, Brazil.
   [Nani, Joao Victor; Hayashi, Mirian A. F.] Univ Sao Paulo FMRP USP, Fac Med Ribeirao Preto, Natl Inst Translat Med INCT TM, CNPq, BR-14049900 Sao Paulo, Brazil.
C3 Universidade Estadual de Campinas; Universidade Federal de Sao Paulo
   (UNIFESP); Universidade de Sao Paulo
RP Tasic, L (corresponding author), Univ Estadual Campinas UNICAMP, Inst Quim, BR-13083970 Campinas, Brazil.; Hayashi, MAF (corresponding author), Univ Fed Sao Paulo UNIFESP, Escola Paulista Med EPM, Dept Farmacol, BR-04044020 Sao Paulo, Brazil.; Hayashi, MAF (corresponding author), Univ Sao Paulo FMRP USP, Fac Med Ribeirao Preto, Natl Inst Translat Med INCT TM, CNPq, BR-14049900 Sao Paulo, Brazil.
EM banny.barbosa@gmail.com; joaoonanii@gmail.com; raniery014@gmail.com;
   danijela@unicamp.br; tassiabrena@gmail.com; mhayashi@unifesp.br;
   ljubica@unicamp.br
RI Hayashi, Mirian/C-7458-2012; Nani, Joao/KLD-9620-2024; Costa, Tássia
   Brena/ABI-2280-2020; CORREIA, BANNY/L-6351-2017; Tasic,
   Ljubica/C-3760-2013
OI Tasic, Ljubica/0000-0003-2930-7332; SILVA BARBOSA CORREIA,
   BANNY/0000-0002-9283-8163; Nani, Joao/0000-0002-4336-1709; Barroso
   Carneiro da Costa, Tassia Brena/0000-0001-5028-5815
FU FAPESP [2017/02413-1, 2019/13112-8, 2019/09207-3, 2014/50867-3,
   2018/24069-3, 2021/01051-4]; CNPq [477760/2010-4, 557753/2010-4,
   508113/2010-5, 311815/2012-0, 475739/2013-2, 309337/2016-0]; National
   Institute for Translational Medicine (INCT-TM); Coordenacao de
   Aperfeicoamento de Pessoal de Nivel Superior (CAPES), Brazil [001]
FX Mirian A. F. Hayashi is supported by FAPESP (Grants 2017/02413-1,
   2019/13112-8), CNPq (477760/2010-4; 557753/2010-4; 508113/2010-5;
   311815/2012-0; 475739/2013-2; 309337/2016-0), and National Institute for
   Translational Medicine (INCT-TM). Joao V. Nani is a recipient of a
   fellowship from FAPESP (2019/09207-3). Ljubica Tasic received FAPESP
   Grants (2014/50867-3, 2018/24069-3), thanks to CNPq, INCTBio, and *grant
   #2021/01051-4 from FAPESP. This study was financed in part by the
   Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES),
   Brazil-Finance Code 001. We thank the support from FAPESP, grant number
   2021/01051-4.
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NR 61
TC 21
Z9 21
U1 0
U2 8
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2227-9059
J9 BIOMEDICINES
JI Biomedicines
PD MAR
PY 2021
VL 9
IS 3
AR 235
DI 10.3390/biomedicines9030235
PG 15
WC Biochemistry & Molecular Biology; Medicine, Research & Experimental;
   Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Biochemistry & Molecular Biology; Research & Experimental Medicine;
   Pharmacology & Pharmacy
GA RD3UF
UT WOS:000633406700001
PM 33652776
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Dieset, I
   Hope, S
   Ueland, T
   Bjella, T
   Agartz, I
   Melle, I
   Aukrust, P
   Rossberg, JI
   Andreassen, OA
AF Dieset, Ingrid
   Hope, Sigrun
   Ueland, Thor
   Bjella, Thomas
   Agartz, Ingrid
   Melle, Ingrid
   Aukrust, Pal
   Rossberg, Jan-Ivar
   Andreassen, Ole A.
TI Cardiovascular risk factors during second generation antipsychotic
   treatment are associated with increased C-reactive protein
SO SCHIZOPHRENIA RESEARCH
LA English
DT Article
DE Cardiovascular risk factors; Inflammation; Second generation
   antipsychotics; Schizophrenia; Bipolar disorder
ID SEVERE MENTAL-DISORDERS; VON-WILLEBRAND-FACTOR; BIPOLAR DISORDER;
   CYTOKINE ALTERATIONS; METABOLIC SYNDROME; SCHIZOPHRENIA; DISEASE;
   ATHEROSCLEROSIS; INFLAMMATION; DRUGS
AB Objective: Severe mental disorder and cardiovascular disease (CVD) are often associated, and inflammation is implicated in both disorders. We investigated whether there is a relationship between CVD risk factors and inflammation in schizophrenia or bipolar disorder, and if second generation antipsychotics (SGA) interact.
   Methods: We included 361 patients in a naturalistic cross-sectional study, 235 subjects on current SGA treatment and 126 subjects not treated with SGA as controls. Cardiovascular parameters were measured and current medication recorded. Fasting plasma levels of the following cytokines were measured: high sensitivity CRP (hsCRP), soluble tumor necrosis factor receptor 1 (sTNF-R1), osteoprotegerin (OPG), soluble CD40 ligand (sCD40L), interleukin-1 receptor antagonist (IL-1Ra), von Willebrand factor (vWf) and interleukin-6 (IL-6).
   Results: In this relatively young sample of patients with a mean age of 33.3 years, the following CVD risk factors were associated with elevated inflammation markers after adjusting for confounders: BMI, triglycerides and glucose with hsCRP (p=0.041-0.001), HDL-cholesterol and triglycerides with sTNF-R1 (p=0.009-0.001) and triglycerides with vWf (p=0.004). In patients treated with SGA, elevated hsCRP was significantly associated with high BMI (p=0.012), and with high glucose levels (p=0.003).
   Conclusion: Several CVD risk factors are associated with elevated levels of inflammation markers in young patients with severe mental illness. The interaction between SGA and CVD risk factors on hsCRP levels might indicate a specific inflammatory activation related to SGA induced overweight and hyperglycemia. This suggests that hsCRP could be a valuable marker for future cardiovascular events, particularly in patients treated with SGA. (C) 2012 Elsevier B.V. All rights reserved.
C1 [Dieset, Ingrid] Oslo Univ Hosp, Div Mental Hlth & Addict, Psychosis Res Sect, TOP, N-0407 Oslo, Norway.
   [Dieset, Ingrid; Hope, Sigrun; Bjella, Thomas; Agartz, Ingrid; Melle, Ingrid; Rossberg, Jan-Ivar; Andreassen, Ole A.] Univ Oslo, Inst Clin Med, Oslo, Norway.
   [Hope, Sigrun] Ostfold Hosp, Dept Psychiat, Fredrikstad, Norway.
   [Agartz, Ingrid] Diakonhjemmet Hosp, Dept Psychiat Res, Oslo, Norway.
   [Ueland, Thor; Aukrust, Pal] Oslo Univ Hosp, Internal Med Res Inst, N-0407 Oslo, Norway.
   [Ueland, Thor] Oslo Univ Hosp, Dept Endocrinol, N-0407 Oslo, Norway.
   [Aukrust, Pal] Oslo Univ Hosp, Sect Clin Immunol & Infect Dis, N-0407 Oslo, Norway.
C3 University of Oslo; University of Oslo; Diakonhjemmet Hospital;
   University of Oslo; University of Oslo; University of Oslo
RP Dieset, I (corresponding author), Oslo Univ Hosp, Div Mental Hlth & Addict, Psychosis Res Sect, TOP, Bldg 49,Kirkeveien 166, N-0407 Oslo, Norway.
EM ingrid.dieset@medisin.uio.no
RI Andreassen, Ole/AAY-7531-2020; Melle, Ingrid/B-4858-2011; Hope,
   Sigrun/JPX-2506-2023
OI Bjella, Thomas/0000-0002-4509-5133; Andreassen, Ole
   A./0000-0002-4461-3568; Agartz, Ingrid/0000-0002-9839-5391; Hope,
   Sigrun/0000-0003-0115-5285
FU University of Oslo; Research Council of Norway [167153/V50, 163070/V50];
   South-East Norway Health Authority [2004123, 2007050]; Lundbeck
FX The study was supported by grants to the TOP study group from the
   University of Oslo, the Research Council of Norway (#167153/V50,
   #163070/V50), and the South-East Norway Health Authority (#2004123,
   #2007050). The funding sources had no influence on study design, data
   collection or on any aspect of the publication.ID has received a
   research award sponsored by Lundbeck. IM has received Speaker's
   honorarium from Janssen and AstraZeneca. OAA has received Speaker's
   honorarium from AstraZeneca, Janssen, BMS and GSK. SH, TB, TU, IA, PA
   and JIR report no conflicts of interest to disclose.
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NR 44
TC 33
Z9 35
U1 0
U2 6
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0920-9964
J9 SCHIZOPHR RES
JI Schizophr. Res.
PD SEP
PY 2012
VL 140
IS 1-3
BP 169
EP 174
DI 10.1016/j.schres.2012.06.040
PG 6
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 996FK
UT WOS:000308070000029
PM 22817875
DA 2025-06-11
ER

PT J
AU Neagu, M
   Constantin, C
   Surcel, M
   Munteanu, A
   Scheau, C
   Savulescu-Fiedler, I
   Caruntu, C
AF Neagu, Monica
   Constantin, Carolina
   Surcel, Mihaela
   Munteanu, Adriana
   Scheau, Cristian
   Savulescu-Fiedler, Ilinca
   Caruntu, Constantin
TI Diabetic neuropathy: A NRF2 disease?
SO JOURNAL OF DIABETES
LA English
DT Review
DE biomarker; diabetic neuropathy; inflammation; NRF2; therapy target
ID NF-KAPPA-B; GLUCOSE-INDUCED INJURY; ROOT GANGLION NEURONS; NONCODING RNA
   MALAT1; OXIDATIVE STRESS; MITOCHONDRIAL DYSFUNCTION; SIGNALING PATHWAY;
   ROSMARINIC ACID; NRF-2/HO-1 ACTIVATION; THERAPEUTIC TARGET
AB The transcription factor nuclear factor erythroid 2-related factor 2 (NRF2) has multifarious action with its target genes having redox-regulating functions and being involved in inflammation control, proteostasis, autophagy, and metabolic pathways. Therefore, the genes controlled by NRF2 are involved in the pathogenesis of myriad diseases, such as cardiovascular diseases, metabolic syndrome, neurodegenerative diseases, autoimmune disorders, and cancer. Amidst this large array of diseases, diabetic neuropathy (DN) occurs in half of patients diagnosed with diabetes and appears as an injury inflicted upon peripheral and autonomic nervous systems. As a complex effector factor, NRF2 has entered the spotlight during the search of new biomarkers and/or new therapy targets in DN. Due to the growing attention for NRF2 as a modulating factor in several diseases, including DN, this paper aims to update the recently discovered regulatory pathways of NRF2 in oxidative stress, inflammation and immunity. It presents the animal models that further facilitated the human studies in regard to NRF2 modulation and the possibilities of using NRF2 as DN biomarker and/or as target therapy.
C1 [Neagu, Monica; Constantin, Carolina; Surcel, Mihaela; Munteanu, Adriana] Victor Babes Natl Inst Pathol, Immunol Dept, Bucharest, Romania.
   [Neagu, Monica; Constantin, Carolina] Colentina Clin Hosp, Pathol Dept, Bucharest, Romania.
   [Neagu, Monica] Univ Bucharest, Fac Biol, Doctoral Sch, Bucharest, Romania.
   [Scheau, Cristian; Caruntu, Constantin] Carol Davila Univ Med & Pharm, Dept Physiol, Bucharest, Romania.
   [Savulescu-Fiedler, Ilinca] Carol Davila Univ Med & Pharm, Dept Internal Med, Coltea Clin Hosp, Bucharest, Romania.
   [Caruntu, Constantin] Prof NC Paulescu Natl Inst Diabet Nutr & Metab, Dept Dermatol, Bucharest, Romania.
C3 Victor Babes National Institute of Pathology; University of Bucharest;
   Carol Davila University of Medicine & Pharmacy; Carol Davila University
   of Medicine & Pharmacy
RP Constantin, C (corresponding author), Victor Babes Natl Inst Pathol, Immunol Dept, Bucharest, Romania.
EM caroconstantin@gmail.com
RI Caruntu, Constantin/AAK-4628-2020; Scheau, Cristian/AAC-3378-2021;
   Surcel, Mihaela/AFS-0892-2022; Munteanu, Adriana Narcisa/AFS-0865-2022;
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FU III
FX No Statement Availabler No Statement Availabler No Statement Available
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NR 160
TC 8
Z9 8
U1 7
U2 14
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1753-0393
EI 1753-0407
J9 J DIABETES
JI J. Diabetes
PD SEP
PY 2024
VL 16
IS 9
DI 10.1111/1753-0407.13524
EA DEC 2023
PG 18
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA G6O6E
UT WOS:001134286200001
PM 38158644
OA gold
DA 2025-06-11
ER

PT J
AU Carreira, D
   Robison, JW
   Robison, S
   Fitch, A
AF Carreira, Dominic
   Robison, J. Weston
   Robison, Susannah
   Fitch, Angela
TI Obesity Treatment in Orthopaedic Surgery
SO JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS
LA English
DT Review
ID BODY-MASS INDEX; WEIGHT-LOSS; BARIATRIC SURGERY; TOTAL HIP;
   CONTROLLED-TRIAL; ARTHROPLASTY; METAANALYSIS; OVERWEIGHT; EXERCISE;
   OUTCOMES
AB According to the World Health Organization, obesity is a global health epidemic, which has nearly tripled in prevalence since 1975. Worldwide in 2016, 13% of adults 18 years and older had obesity (body mass index >= 30 kg/m(2)) and 39% were overweight (body mass index 25.0 to 29.9 kg/m(2)). In the United States, approximately 35% of adults have obesity and 31% are overweight. Obesity increases stress throughout the musculoskeletal system and carries a higher risk for the development of osteoarthritis and various other musculoskeletal conditions. When patients with obesity undergo orthopaedic procedures, weight loss is a critical aspect to appropriate preoperative counseling and treatment. Weight loss can improve obesity-related comorbidities such as metabolic syndrome, diabetes, cardiovascular disease, and obstructive sleep apnea, which in turn may reduce complications, minimize long-term joint stress, and improve outcomes among patients undergoing orthopaedic procedures. The effects of obesity on patients undergoing total joint arthroplasty has been previously described, with reported associations of increased risk of infection, revision, blood loss, venous thromboembolism, and overall costs. The purpose of this article was to provide orthopaedic surgeons with strategies for obesity treatment.
C1 [Carreira, Dominic] Peachtree Orthoped, Atlanta, GA 30309 USA.
   [Robison, J. Weston] WellStar Atlanta Med Ctr, Dept Orthopaed Surg, Orthopaed Surg Resident, Atlanta, GA USA.
   [Robison, Susannah] Ethica Hlth & Retirement Communities, Reg Dietitian, Gray, France.
   [Fitch, Angela] Fac Harvard Med Sch, Massachusetts Hosp Weight Ctr, Div Endocrinol, Boston, MA USA.
C3 WellStar Atlanta Medical Center
RP Carreira, D (corresponding author), Peachtree Orthoped, Atlanta, GA 30309 USA.
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NR 45
TC 5
Z9 5
U1 1
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1067-151X
EI 1940-5480
J9 J AM ACAD ORTHOP SUR
JI J. Am. Acad. Orthop. Surg.
PD DEC 15
PY 2022
VL 30
IS 24
BP E1563
EP E1570
DI 10.5435/JAAOS-D-21-01083
PG 8
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Surgery
GA 6U2CW
UT WOS:000894177900008
PM 36476464
DA 2025-06-11
ER

PT J
AU Majeed, U
   Shafi, A
   Majeed, H
   Akram, K
   Liu, XH
   Ye, JM
   Luo, YE
AF Majeed, Usman
   Shafi, Afshan
   Majeed, Hamid
   Akram, Kashif
   Liu, Xuehua
   Ye, Jianming
   Luo, Yane
TI Grape (Vitis vinifera L.) phytochemicals and their
   biochemical protective mechanisms against leading pathologies
SO FOOD CHEMISTRY
LA English
DT Article
DE Grapes(Vitis viniferaL; ); Plolyphenols; DNA damage repair; Gene
   expression modulation; Cardiovascular disease; Health promotion
ID ANTIOXIDANT DIETARY FIBER; INDUCED OXIDATIVE STRESS; SEED EXTRACT;
   PHENOLIC-COMPOUNDS; POLYPHENOLIC COMPOUNDS; BIOACTIVE COMPOUNDS;
   CANCER-CELLS; TUMOR-GROWTH; BLACK-BERRY; IN-VITRO
AB The intake of herbal dietary constituents, mostly fruits and vegetables, have been considered well-known to prevent pathologies (degenerative diseases). Consumer awareness/concern regarding a balanced diet has increased their importance in the food chain. Grapes (Vitis vinifera L.), being native to the Mediterranean region, central Europe, and southwest Asia, is a rich source of nutritive (sugar, vitamins, minerals) and non-nutritive/ therapeutic or functional bioactive compounds like quercetin, resveratrol and epigallocatechin-3-gallate that could synergistically help in health promotion. Their disease prevention mechanisms are free radical scavenging, DNA damage repair, and modulation of gene expression in proliferation, metabolism, cell survival, and anti-oxidant defense. This review provides an excellent summary of grape phytochemicals in vivo molecular mech-anisms that lead to health promotion by avoiding oxidative stress-related pathologies like cancer, neurodegeneration, metabolic syndrome, inflammation and cardiovascular diseases. Grape intake-driven dis-ease-preventing mechanism/targets could help to synchronize for an improved efficacy in human pathologies.
C1 [Majeed, Usman; Liu, Xuehua; Ye, Jianming; Luo, Yane] Northwest Univ, Coll Food Sci & Technol, Xian 710069, Shaanxi, Peoples R China.
   [Shafi, Afshan] MNS Univ Agr Multan, Dept Food Sci & Technol, Multan, Pakistan.
   [Majeed, Hamid; Akram, Kashif] Cholistan Univ Vet & Anim Sci, Dept Food Sci & Technol, Bahawalpur, Pakistan.
C3 Northwest University Xi'an
RP Luo, YE (corresponding author), Northwest Univ, Coll Food Sci & Technol, Xian 710069, Shaanxi, Peoples R China.
EM luoyane@nwu.edu.cn
RI Majeed, Hamid/G-4637-2017; Akram, Kashif/AAW-7466-2020
OI Majeed, Usman/0000-0002-2001-1036
FU National Key Research and Development Program; Nat-ural Science
   Foundation of Shaanxi Province;  [2019YFC1606704];  [2018JM2037]
FX Acknowledgements This work was financially supported by the National Key
   Research and Development Program (Grant No. 2019YFC1606704) and the
   Nat-ural Science Foundation of Shaanxi Province (Grant No. 2018JM2037) .
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NR 173
TC 18
Z9 18
U1 2
U2 36
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 0308-8146
EI 1873-7072
J9 FOOD CHEM
JI Food Chem.
PD MAR 30
PY 2023
VL 405
AR 134762
DI 10.1016/j.foodchem.2022.134762
EA NOV 2022
PN A
PG 14
WC Chemistry, Applied; Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Food Science & Technology; Nutrition & Dietetics
GA 6V8DN
UT WOS:000895271300003
DA 2025-06-11
ER

PT J
AU Cerrillo, I
   Escudero-López, B
   Ortega, A
   Martín, F
   Fernández-Pachón, MS
AF Cerrillo, I
   Escudero-Lopez, B.
   Ortega, A.
   Martin, F.
   Fernandez-Pachon, M. S.
TI Effect of daily intake of a low-alcohol orange beverage on
   cardiovascular risk factors in hypercholesterolemic humans
SO FOOD RESEARCH INTERNATIONAL
LA English
DT Article
DE Orange; Bioactive compounds; Alcohol; Cardiovascular risk factor; Lipid
   profile; Hypercholesterolemic humans
ID ANTIOXIDANT ACTIVITY; LIPID-PEROXIDATION; METABOLIC SYNDROME;
   PHENOLIC-COMPOUNDS; INFLAMMATORY BIOMARKERS; ADHESION MOLECULES; JUICE
   CONSUMPTION; OXIDATIVE STRESS; FRUIT JUICES; VITAMIN-C
AB Oxidative stress, inflammation status, endothelial dysfunction, and imbalanced lipid metabolism play a major role in cardiovascular disease. Bioactive compounds and moderate alcohol consumption have been associated with decreased cardiovascular risk. This study aimed to evaluate the effect on cardiovascular risk factors of a low-alcohol beverage derived from the alcoholic fermentation of orange juice. Eighteen individuals with moderately high cholesterol levels were randomly assigned to an experimental group (n = 9) who drank 500 mL/day of the orange beverage for 2 weeks or a control group (n = 9) who drank no orange beverage. Blood samples were drawn at the beginning and end of the study period. Consumption of the beverage significantly decreased plasma levels of total cholesterol (-15.6%), LDL-cholesterol (-17.8%), LDL-cholesterol/HDL-cholesterol ratio (-1.4%), catalase (-25.5%), TSARS (-42.6%), and sVCAM-1 (-5.8%). This orange beverage would have a potential capacity to improve cardiovascular risk in hypercholesterolemic humans, supporting its future consideration as a functional beverage.
C1 [Cerrillo, I; Escudero-Lopez, B.; Ortega, A.; Martin, F.; Fernandez-Pachon, M. S.] Univ Pablo de Olavide, Dept Biol Mol & Ingn Bioquim, Area Nutr & Bromatol, Ctra Utrera Km 1, Seville 41013, Spain.
   [Cerrillo, I; Fernandez-Pachon, M. S.] Univ Autonoma Chile, Fac Ciencias Salud, Avda Pedro de Valdivia 425, Providencia, Santiago De Chi, Chile.
   [Ortega, A.; Martin, F.] Univ Pablo de Olavide, CIBER Diabet & Enfermedades Metab Asoc CIBERDEM, Seville, Spain.
C3 Universidad Pablo de Olavide; Universidad Autonoma de Chile; Universidad
   Pablo de Olavide
RP Cerrillo, I (corresponding author), Univ Pablo de Olavide, Carretera Utrera Km 1, Seville 41013, Spain.
EM icergar@upo.es
RI Fernández-Pachón, María-Soledad/GOE-5442-2022; Ortega,
   Angeles/ABA-8118-2020; Escudero-Lopez, Blanca/ABG-3957-2020; Martin,
   Franz/K-4197-2014; Cerrillo Garcia, Isabel/K-1455-2016
OI Fernandez-Pachon, Maria-Soledad/0000-0002-9524-298X; Escudero-Lopez,
   Blanca/0000-0002-4964-1306; Martin, Franz/0000-0002-5745-8704; Ortega de
   la Torre, Maria de los Angeles/0000-0002-0503-5793; Cerrillo Garcia,
   Isabel/0000-0001-9068-8176
FU Junta de Andalucia [P09-AGR4814M, PAI BIO311]
FX This work was supported by grants from Project P09-AGR4814M and Grupo
   PAI BIO311 (Junta de Andalucia).
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NR 60
TC 12
Z9 12
U1 2
U2 14
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0963-9969
EI 1873-7145
J9 FOOD RES INT
JI Food Res. Int.
PD FEB
PY 2019
VL 116
BP 168
EP 174
DI 10.1016/j.foodres.2018.08.008
PG 7
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA HL7TC
UT WOS:000458942900018
PM 30716933
DA 2025-06-11
ER

PT J
AU Ivanova, D
   Tasinov, O
   Kiselova-Kaneva, Y
AF Ivanova, Diana
   Tasinov, Oskan
   Kiselova-Kaneva, Yoana
TI Improved lipid profile and increased serum antioxidant capacity in
   healthy volunteers after Sambucus ebulus L. fruit infusion
   consumption
SO INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION
LA English
DT Article
DE Hypolipidemic; LDL-cholesterol; medicinal plant; total cholesterol;
   total thiols; triglycerides
ID CORONARY-ARTERY-DISEASE; ESTER TRANSFER PROTEIN; MEDICINAL-PLANTS;
   OXIDATIVE STRESS; ANTHOCYANIN EXTRACT; INSULIN-RESISTANCE; METABOLIC
   SYNDROME; DIABETIC-PATIENTS; HDL-CHOLESTEROL; FOLK REMEDIES
AB This study aimed to establish the effect of Sambucus ebulus L. (SE) ripe fruit infusion on body weight, blood pressure, glucose levels, lipid profile and antioxidant markers in healthy volunteers in respect of its possible protective activity against cardiovascular diseases and other oxidative stress-related diseases. The study involved 21 healthy volunteers, aged between 20 and 59, BMI 23.12 +/- 1.31, who consumed 200 ml SE infusion/day for a period of 30 d. Blood samples were collected before and at the end of the intervention. Significant decrease in triglycerides (14.92%), total cholesterol (15.04%) and LDL-C (24.67%) was established at the end of the study. In addition, HDL-C/LDL-C ratio increased by 42.77%. Improved serum antioxidant capacity and total thiol levels were also established. The results presented in this first human intervention study with SE fruit infusion indicate the potential of the plant to improve lipid profile and serum antioxidant capacity in humans.
C1 [Ivanova, Diana; Tasinov, Oskan; Kiselova-Kaneva, Yoana] Med Univ Varna, Dept Biochem Mol Med & Nutrigen, Varna 9002, Bulgaria.
C3 Medical University Varna
RP Ivanova, D (corresponding author), Med Univ Varna, Dept Biochem Mol Med & Nutrigen, 55 Marin Drinov Str, Varna 9002, Bulgaria.
EM divanova@mu-varna.bg
RI Ivanova, Diana/JVY-8696-2024; Tasinov, Oskan/W-4363-2018
OI Tasinov, Oskan/0000-0001-7268-3937; Ivanova, Diana/0000-0002-4502-081X
FU COST Action BM0602 [DKOF FP7 02/13/05.07.2010]; Medical University-Varna
FX The research was funded by COST Action BM0602, Grant No DKOF FP7
   02/13/05.07.2010 "Adipose tissue - a key target for metabolic syndrome''
   and Medical University-Varna. The authors declare that there are no
   financial/commercial conflicts of interest.
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NR 59
TC 23
Z9 23
U1 0
U2 13
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0963-7486
EI 1465-3478
J9 INT J FOOD SCI NUTR
JI Int. J. Food Sci. Nutr.
PD SEP
PY 2014
VL 65
IS 6
BP 740
EP 744
DI 10.3109/09637486.2014.898256
PG 5
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA AN8DB
UT WOS:000340831400014
PM 24625072
DA 2025-06-11
ER

PT J
AU Rhee, Y
   Brunt, A
AF Rhee, Yeong
   Brunt, Ardith
TI Flaxseed supplementation improved insulin resistance in obese glucose
   intolerant people: a randomized crossover design
SO NUTRITION JOURNAL
LA English
DT Article
DE flaxseed insulin resistance; oxidative stress; inflammation
ID TUMOR-NECROSIS-FACTOR; C-REACTIVE PROTEIN; OXIDATIVE STRESS;
   FACTOR-ALPHA; METABOLIC SYNDROME; ANIMAL-MODEL; DOUBLE-BLIND; MOUSE
   MODEL; INFLAMMATION; MARKERS
AB Background: Obesity leads to an increase in inflammation and insulin resistance. This study determined antioxidant activity of flaxseed and its role in inflammation and insulin resistance in obese glucose intolerant people.
   Methods: Using a randomized crossover design, nine obese glucose intolerant people consumed 40 g ground flaxseed or 40 g wheat bran daily for 12 weeks with a 4-week washout period. Plasma inflammation biomarkers (CRP, TNF-alpha, and IL-6), glucose, insulin, and thiobaribituric acid reactive substance (TBARS) were measured before and after of each supplementation.
   Results: Flaxseed supplementation decreased TBARS (p = 0.0215) and HOMA-IR (p = 0.0382). Flaxseed or wheat bran supplementation did not change plasma inflammatory biomarkers. A positive relationship was found between TBARS and HOMA-IR (r = 0.62, p = 0.0003).
   Conclusions: The results of the study weakly support that decreased insulin resistance might have been secondary to antioxidant activity of flaxseed. However, the mechanism(s) of decreased insulin resistance by flaxseed should be further determined using flaxseed lignan.
C1 [Rhee, Yeong; Brunt, Ardith] N Dakota State Univ Fargo, Dept Hlth Nutr & Exercise Sci, Fargo, ND 58108 USA.
C3 North Dakota State University Fargo
RP Rhee, Y (corresponding author), N Dakota State Univ Fargo, Dept Hlth Nutr & Exercise Sci, Fargo, ND 58108 USA.
EM yeong.rhee@ndsu.edu
FU North Dakota State University; North Dakota Oilseed Council
FX This study was supported by grants from North Dakota State University
   Research Development Support Program and North Dakota Oilseed Council.
   The authors thank volunteers for participating in the study, and Curt
   Doetkott for aiding in statistical analyses. The authors express special
   thanks to Dr. Jack Carter, emeritus professor at North Dakota State
   University, for providing his expertise in flaxseed, acquiring flaxseed
   and durum wheat bran, and arranging proximate and lignan analyses for
   the study. The authors also like to acknowledge North Dakota Oilseed
   (flaxseed) Council, Bismark, ND, for provision of ground full-fat yellow
   omega flaxseed and Dakota Growers Pasta Co., Carrington, ND, for
   provision of durum wheat bran throughout the study. The authors also
   thank Professor Gregory Gass for critical review of the manuscript. The
   authors thank the North Dakota State University College of Human
   Development and Education and the Department of Health, Nutrition, and
   Exercise Sciences for the print charge support.
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   ORAL GLUCOSE TOLERAN
NR 57
TC 83
Z9 87
U1 1
U2 18
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1475-2891
J9 NUTR J
JI Nutr. J.
PD MAY 9
PY 2011
VL 10
AR 44
DI 10.1186/1475-2891-10-44
PG 7
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 777IE
UT WOS:000291608300001
PM 21554710
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Castellini, G
   Lelli, L
   Cassioli, E
   Ricca, V
AF Castellini, Giovanni
   Lelli, Lorenzo
   Cassioli, Emanuele
   Ricca, Valdo
TI Relationships between eating disorder psychopathology, sexual hormones
   and sexual behaviours
SO MOLECULAR AND CELLULAR ENDOCRINOLOGY
LA English
DT Review
DE Sexuality; Eating disorders; Hormonal alterations; Sexual dysfunction;
   Risky sexual behaviours
ID SELF-INJURIOUS-BEHAVIOR; 10-YEAR FOLLOW-UP; ANOREXIA-NERVOSA;
   BULIMIA-NERVOSA; METABOLIC SYNDROME; YOUNG-WOMEN;
   PERSONALITY-DEVELOPMENT; ERECTILE DYSFUNCTION; CHILDHOOD ABUSE; RISK
   BEHAVIORS
AB A growing body of evidences demonstrated that sexuality is an important topic in the clinical research of eating disorders (EDs), due to its association with specific psychopathological features, and etiological factors. The present review took into consideration the complex relationship between sexual behaviours, hormonal alterations and EDs psychopathology. Studies pertaining sexual behaviours in EDs were divided into those focusing on sexual dysfunctions, and those related to risky sexual behaviours. The limited number of studies on sexual dysfunctions, reported a controversial association with weight status and hormonal alterations, and a clear relationship with severity of specific psychopathology (e.g. body image disturbance). Risky sexual behaviours have been associated with impulsivity and dissociation, as well as with abnormal stress response. Finally, both restriction and uncontrolled eating have been found to be responsible for several complex metabolic alterations, determining varied sexual and gynecologic problems, such as amenorrhea, hypogonadism, genital vascular problems, infertility, and miscarriage, although it is also possible that alterations in feeding and stress hormones contribute to altered eating behaviour.
C1 [Castellini, Giovanni; Lelli, Lorenzo; Cassioli, Emanuele; Ricca, Valdo] Univ Florence, Psychiat Unit, Dept Hlth Sci, Largo Brambilla 3, I-50134 Florence, Italy.
C3 University of Florence
RP Ricca, V (corresponding author), Univ Florence, Psychiat Unit, Dept Hlth Sci, Largo Brambilla 3, I-50134 Florence, Italy.
EM valdo.ricca@unifi.it
RI castellini, giovanni/AAC-3195-2019; ricca, valdo/K-8382-2012; Cassioli,
   Emanuele/Q-1181-2019
OI Castellini, Giovanni/0000-0003-1265-491X; ricca,
   valdo/0000-0002-9291-2124; Cassioli, Emanuele/0000-0003-3623-7096
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NR 128
TC 25
Z9 25
U1 2
U2 32
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0303-7207
EI 1872-8057
J9 MOL CELL ENDOCRINOL
JI Mol. Cell. Endocrinol.
PD NOV 1
PY 2019
VL 497
AR 110429
DI 10.1016/j.mce.2019.04.009
PG 9
WC Cell Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Cell Biology; Endocrinology & Metabolism
GA JF2RT
UT WOS:000491233800007
PM 31026479
DA 2025-06-11
ER

PT J
AU Jia, GH
   Jia, Y
   Sowers, JR
AF Jia, Guanghong
   Jia, Yan
   Sowers, James R.
TI Contribution of Maladaptive Adipose Tissue Expansion to Development of
   Cardiovascular Disease
SO COMPREHENSIVE PHYSIOLOGY
LA English
DT Article
ID HIGH-FAT DIET; NITRIC-OXIDE SYNTHASE; INSULIN-RESISTANCE;
   MINERALOCORTICOID RECEPTOR; DIASTOLIC DYSFUNCTION; OXIDATIVE STRESS;
   HEART-FAILURE; METABOLIC FLEXIBILITY; VASCULAR-DISEASE; OBESITY PARADOX
AB The overweight and obesity epidemic has led to an increase in the metabolic syndrome and associated cardiovascular disease (CVD). These abnormalities include insulin resistance, type 2 diabetes mellitus, vascular stiffness, hypertension, stroke, and coronary heart disease. Visceral white adipocyte tissue (WAT) expansion and associated fibrosis/stiffness of WAT promote insulin resistance and CVD through increases in proinflammatory adipokines, oxidative stress, activation of renin-angiotensin-aldosterone system, dysregulation of adipocyte apoptosis and autophagy, dysfunctional immune modulation, and adverse changes in the gut microbiome. The expansion of WAT is partly determined by activation of peroxisome proliferator-activated receptor gamma and mammalian target of rapamycin/ribosomal S6 kinase signaling pathways. Further, the chronic activation of these signaling pathways may not only induce adipocyte hypertrophy and fibrosis, but also contribute to systemic inflammation, and impairment of insulin metabolic signaling in fat, liver, and skeletal muscle tissue. Therefore, the interplay of adipocyte dysfunction, maladaptive immune and inflammatory responses, and associated metabolic disorders often coexist leading to systemic low-grade inflammation and insulin resistance that are associated with increased CVD in obese individuals. (C) 2017 American Physiological Society.
C1 [Jia, Guanghong; Jia, Yan; Sowers, James R.] Univ Missouri, Sch Med, Diabet & Cardiovasc Res Ctr, Columbia, MO 65211 USA.
   [Sowers, James R.] Univ Missouri, Sch Med, Dept Med Pharmacol & Physiol, Columbia, MO 65211 USA.
   [Sowers, James R.] Univ Missouri, Sch Med, Dalton Cardiovasc Ctr, Columbia, MO 65211 USA.
   [Jia, Guanghong; Sowers, James R.] Harry S Truman Mem Vet Hosp, Columbia, MO 65201 USA.
C3 University of Missouri System; University of Missouri Columbia;
   University of Missouri System; University of Missouri Columbia;
   University of Missouri System; University of Missouri Columbia; US
   Department of Veterans Affairs; Veterans Health Administration (VHA);
   Harry S. Truman Memorial Veterans' Hospital
RP Sowers, JR (corresponding author), Univ Missouri, Sch Med, Diabet & Cardiovasc Res Ctr, Columbia, MO 65211 USA.; Sowers, JR (corresponding author), Univ Missouri, Sch Med, Dept Med Pharmacol & Physiol, Columbia, MO 65211 USA.; Sowers, JR (corresponding author), Univ Missouri, Sch Med, Dalton Cardiovasc Ctr, Columbia, MO 65211 USA.; Sowers, JR (corresponding author), Harry S Truman Mem Vet Hosp, Columbia, MO 65201 USA.
EM sowersj@health.missouri.edu
FU NIH [R01 HL73101-01A, R01 HL107910-01]; Veterans Affairs Merit System
   [0018]
FX J.R.S. received funding from NIH (R01 HL73101-01A and R01 HL107910-01)
   and the Veterans Affairs Merit System (0018). The authors would like to
   thank Brenda Hunter for her editorial assistance.
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NR 104
TC 24
Z9 24
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 2040-4603
J9 COMPR PHYSIOL
JI Compr. Physiol.
PD JAN
PY 2017
VL 7
IS 1
BP 253
EP 262
DI 10.1002/cphy.c160014
PG 10
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA EK8PQ
UT WOS:000394186300010
PM 28135006
DA 2025-06-11
ER

PT J
AU Sloboda, N
   Fève, B
   Thornton, SN
   Nzietchueng, R
   Regnault, V
   Simon, G
   Labat, C
   Louis, H
   Max, JP
   Muscat, A
   Osborne-Pellegrin, M
   Lacolley, P
   Benetos, A
AF Sloboda, Natacha
   Feve, Bruno
   Thornton, Simon N.
   Nzietchueng, Rosine
   Regnault, Veronique
   Simon, Ginny
   Labat, Carlos
   Louis, Huguette
   Max, Jean-Pierre
   Muscat, Adeline
   Osborne-Pellegrin, Mary
   Lacolley, Patrick
   Benetos, Athanase
TI Fatty Acids Impair Endothelium-Dependent Vasorelaxation: A Link Between
   Obesity and Arterial Stiffness in Very Old Zucker Rats
SO JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL
   SCIENCES
LA English
DT Article
DE Aging; Arterial stiffness; Free fatty acids; Obesity; Vascular
   reactivity
ID SPONTANEOUSLY HYPERTENSIVE-RATS; INDUCED INSULIN-RESISTANCE;
   RENIN-ANGIOTENSIN SYSTEM; AGE-RELATED-CHANGES; PROTEIN-KINASE-C;
   METABOLIC SYNDROME; AORTIC STIFFNESS; BLOOD-PRESSURE; RENAL INJURY;
   BODY-WEIGHT
AB To analyze age-related interactions between obesity, its associated metabolic disorders, and macrocirculation, we studied large artery stiffness and fatty acid responsiveness in lean and obese Zucker rats, aged 25 (adult) and 80 weeks (very old). Systolic arterial pressure was higher in old obese than in old lean rats (178 +/- 10 vs 134 +/- 8 mmHg, respectively). Carotid elastic modulus-wall stress curves showed increased age-dependent arterial stiffening, which was greater in obese animals. Old obese exhibited endothelial dysfunction with increased systemic oxidative stress. Adult obese had elevated plasma free fatty acid levels (1,866 +/- 177 vs 310 +/- 34 mu g/mu L in lean animals). In old obese, linoleate and palmitate increased contractility to phenylephrine and reduced relaxation to acetylcholine. Thus, obesity at 25 weeks appears to trigger accelerated arterial aging observed at 80 weeks. The early increase in free fatty acids may be a key effector in the severe arterial stiffness of the aged obese Zucker model.
C1 [Benetos, Athanase] Hop Brabois, CHU Nancy, Dept Geriatr, F-54510 Vandoeuvre Les Nancy, France.
   [Sloboda, Natacha; Thornton, Simon N.; Nzietchueng, Rosine; Regnault, Veronique; Simon, Ginny; Labat, Carlos; Louis, Huguette; Max, Jean-Pierre; Lacolley, Patrick; Benetos, Athanase] INSERM, U961, Vandoeuvre Les Nancy, France.
   [Sloboda, Natacha; Thornton, Simon N.; Nzietchueng, Rosine; Regnault, Veronique; Simon, Ginny; Labat, Carlos; Louis, Huguette; Max, Jean-Pierre; Lacolley, Patrick; Benetos, Athanase] Univ Henri Poincare, Vandoeuvre Les Nancy, France.
   [Feve, Bruno; Muscat, Adeline] INSERM, UMR S938, Paris, France.
   [Feve, Bruno; Muscat, Adeline] Univ Paris 06, Fac Med St Antoine, F-75252 Paris 05, France.
   [Feve, Bruno] Hop St Antoine, AP HP, Serv Endocrinol, Paris, France.
   [Osborne-Pellegrin, Mary] INSERM, U698, Paris, France.
   [Osborne-Pellegrin, Mary] Univ Paris Diderot, Sorbonne Paris Cite, Paris, France.
C3 CHU de Nancy; Universite de Lorraine; Institut National de la Sante et
   de la Recherche Medicale (Inserm); Universite de Lorraine; Institut
   National de la Sante et de la Recherche Medicale (Inserm); Sorbonne
   Universite; Assistance Publique Hopitaux Paris (APHP); Sorbonne
   Universite; Hopital Universitaire Saint-Antoine - APHP; Institut
   National de la Sante et de la Recherche Medicale (Inserm); Universite
   Paris Cite
RP Benetos, A (corresponding author), Hop Brabois, CHU Nancy, Dept Geriatr, F-54510 Vandoeuvre Les Nancy, France.
EM a.benetos@chu-nancy.fr
RI Lacolley, Patrick/G-3118-2013; Benetos, Athanase/JJC-4282-2023;
   REGNAULT, Veronique/AAY-1711-2020; Labat, Carlos/F-7492-2010
OI Labat, Carlos/0000-0002-5275-3405; Feve, Bruno/0000-0001-6577-9009
FU Institut National de la Sante et de la Recherche Medicale; Henri
   Poincare Universite of Vandoeuvre-les-Nancy, France; "la Region
   Lorraine"; La Fondation pour la Recherche Medicale [FRM DCV-20070409250]
FX This work was supported by grants from Institut National de la Sante et
   de la Recherche Medicale, Henri Poincare Universite of
   Vandoeuvre-les-Nancy, France, "la Region Lorraine", and La Fondation
   pour la Recherche Medicale (FRM DCV-20070409250).
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NR 65
TC 16
Z9 19
U1 0
U2 1
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1079-5006
J9 J GERONTOL A-BIOL
JI J. Gerontol. Ser. A-Biol. Sci. Med. Sci.
PD SEP
PY 2012
VL 67
IS 9
BP 927
EP 938
DI 10.1093/gerona/glr236
PG 12
WC Geriatrics & Gerontology; Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA 998LP
UT WOS:000308240900002
PM 22389459
OA Bronze
DA 2025-06-11
ER

PT J
AU Chaudhry, A
   Noor, J
   Batool, S
   Fatima, G
   Noor, R
AF Chaudhry, Ahtshamullah
   Noor, Jawad
   Batool, Saima
   Fatima, Ghulam
   Noor, Riwad
TI Advancements in Diagnostic and Therapeutic Interventions of
   Non-alcoholic Fatty Liver Disease: A Literature Review
SO CUREUS JOURNAL OF MEDICAL SCIENCE
LA English
DT Review
DE therapeutic; diagnostic; innovations; non-alcoholic steatohepatitis;
   non-alcoholic fatty liver disease
ID NAFLD
AB Non-alcoholic fatty liver disease (NAFLD) is one of the most common diseases of the liver globally. Non-alcoholic steatohepatitis (NASH) has a complicated pathophysiology which includes lipid buildup, oxidative stress, endoplasmic reticulum stress, and lipotoxicity. Recently, there has been tremendous improvement in understanding of NASH pathogenesis due to advancements in the scientific field. It is being investigated how non-invasive circulating and imaging biomarkers can help in NAFLD and NASH diagnosis and monitoring the progress. Multiple medications are now undergoing clinical trials for the treatment of NASH, and lifestyle changes have been acknowledged as one of the main treatment methods. The purpose of this review article is to discuss the incidence of NAFLD globally, management issues with NASH, and its relation to the metabolic syndrome. It explains pathophysiology as well as therapeutic strategies using natural items, dietary changes, and pharmaceutical treatments. While emphasizing the necessity for surrogate endpoints to facilitate medication development for NASH, the study also considers the potential of non-invasive imaging biomarkers including magnetic resonance imaging (MRI) and magnetic resonance elastography (MRE).
C1 [Chaudhry, Ahtshamullah; Noor, Jawad] St Domin Hosp, Internal Med, Jackson, MS 39216 USA.
   [Batool, Saima] Nishtar Med Univ Multan, Pathol, Multan, Pakistan.
   [Fatima, Ghulam] Abbasi Shaheed Hosp, Med Unit, Internal Med, Karachi, Pakistan.
   [Noor, Riwad] Nishtar Hosp, Publ Hlth, Multan, Pakistan.
RP Chaudhry, A (corresponding author), St Domin Hosp, Internal Med, Jackson, MS 39216 USA.
EM ahtsham_87@hotmail.com
RI Batool, Dr. Saima/LCP-6261-2024
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NR 37
TC 7
Z9 7
U1 1
U2 7
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
EI 2168-8184
J9 CUREUS J MED SCIENCE
JI Cureus J Med Sci
PD SEP 8
PY 2023
VL 15
IS 9
AR e44924
DI 10.7759/cureus.44924
PG 10
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA Z2DK0
UT WOS:001110233600028
PM 37814734
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Freeman, LR
   Haley-Zitlin, V
   Rosenberger, DS
   Granholm, AC
AF Freeman, Linnea R.
   Haley-Zitlin, Vivian
   Rosenberger, Dorothea S.
   Granholm, Ann-Charlotte
TI Damaging effects of a high-fat diet to the brain and cognition: A review
   of proposed mechanisms
SO NUTRITIONAL NEUROSCIENCE
LA English
DT Review
DE Cognition; Brain Health; Obesity; Inflammation; Cerebrovascularization
ID WHITE-MATTER HYPERINTENSITIES; HIGH SATURATED FAT; HIGH-ENERGY DIET;
   MEMORY IMPAIRMENT; INSULIN-RESISTANCE; ALZHEIMER-DISEASE; OXIDATIVE
   STRESS; RAT HIPPOCAMPUS; US ADULTS; NEURONAL 5-LIPOXYGENASE
AB The prevalence of obesity is growing and now includes at least one-third of the adult population in the United States. As obesity and dementia rates reach epidemic proportions, an even greater interest in the effects of nutrition on the brain have become evident. This review discusses various mechanisms by which a high fat diet and/or obesity can alter the brain and cognition. It is well known that a poor diet and obesity can lead to certain disorders such as type II diabetes, metabolic syndrome, and heart disease. However, long-term effects of obesity on the brain need to be further examined. The contribution of insulin resistance and oxidative stress is briefly reviewed from studies in the current literature. The role of inflammation and vascular alterations are described in more detail due to our laboratory's experience in evaluating these specific factors. It is very likely that each of these factors plays a role in diet-induced and/or obesity-induced cognitive decline.
C1 [Freeman, Linnea R.; Rosenberger, Dorothea S.; Granholm, Ann-Charlotte] Med Univ S Carolina, Dept Neurosci, Charleston, SC 29425 USA.
   [Haley-Zitlin, Vivian] Clemson Univ, Dept Food Sci & Human Nutr, Clemson, SC USA.
   [Rosenberger, Dorothea S.] Med Univ S Carolina, Dept Anesthesia & Perioperat Med, Charleston, SC 29425 USA.
C3 Medical University of South Carolina; Clemson University; Medical
   University of South Carolina
RP Freeman, LR (corresponding author), Med Univ S Carolina, 171 Ashley Ave, Charleston, SC 29425 USA.
EM freemal@musc.edu
FU NIA NIH HHS [F31 AG033482, R01 AG044920] Funding Source: Medline; NIDA
   NIH HHS [T32 DA007288] Funding Source: Medline
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NR 132
TC 239
Z9 266
U1 0
U2 107
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1028-415X
EI 1476-8305
J9 NUTR NEUROSCI
JI Nutr. Neurosci.
PD NOV
PY 2014
VL 17
IS 6
BP 241
EP 251
DI 10.1179/1476830513Y.0000000092
PG 11
WC Neurosciences; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Nutrition & Dietetics
GA AQ0XY
UT WOS:000342507200001
PM 24192577
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Semiz, Y
   Aktas, E
AF Semiz, Yavuz
   Aktas, Ezgi
TI Investigating the role of dietary glycemic factors and antioxidant
   capacity, metabolic status, and oxidative stress in seborrheic
   dermatitis: A case-control study
SO JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
LA English
DT Article
DE diet; glycemic load; metabolic syndrome; seborrheic dermatitis; total
   antioxidant capacity
ID OXIDANT/ANTIOXIDANT STATUS; INDEX; ENERGY; LEPTIN
AB Background: The etiopathogenesis of seborrheic dermatitis (SD) remains unexplained, although several factors have been considered in this regard. Objective: The aim of this study is to investigate diet, metabolic status, and oxidative stress in SD patients. Methods: This prospective, single-center, case-control study included 49 SD patients and 40 gender- and age-matched healthy controls. Results: Dietary total antioxidant capacity values were significantly lower in SD patients than among the controls (7.16 +/- 2.66 vs 12.85 +/- 4.26; P <.001). Glycemic load (GL) values were significantly higher in SD patients (187.2 +/- 57.2 vs 110.6 +/- 46.5; P <.001). The glycemic index and GL values of patients with severe SD were significantly higher than those with mild SD (P = .014, P = .017; respectively). Limitations: The cross-sectional design, small sample size, and the relatively short duration of questioning dietary habits are the limitations of the study. Conclusion: A diet rich in antioxidants and with low glycemic index/GL content may be beneficial in the treatment of SD.
C1 [Semiz, Yavuz] Hlth Sci Univ Istanbul, Haseki Training & Res Hosp, Dept Dermatol, Istanbul, Turkiye.
   [Aktas, Ezgi] Hlth Sci Univ, Okmeydani Training & Res Hosp, Prof Dr Cemil Tascioglu City Hosp, Dept Dermatol, Istanbul, Turkiye.
C3 Istanbul Haseki Training & Research Hospital; University of Health
   Sciences Turkey; Istanbul Okmeydani Training & Research Hospital
RP Semiz, Y (corresponding author), Istanbul Haseki Training & Res Hosp, Dept Dermatol, Ataturk Blv 54, TR-34265 Istanbul, Turkiye.
EM yavuzsemz@gmail.com
RI Semiz, Yavuz/NGR-1294-2025; Aktaş, Ezgi/S-4737-2019
FU Turkish Society of Dermatology
FX Funding sources: The study was funded by Turkish Society of Dermatology.
   There are no commercial funding sources in this study.
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NR 32
TC 0
Z9 0
U1 7
U2 8
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0190-9622
EI 1097-6787
J9 J AM ACAD DERMATOL
JI J. Am. Acad. Dermatol.
PD MAR
PY 2025
VL 92
IS 3
BP 503
EP 510
DI 10.1016/j.jaad.2024.10.078
EA FEB 2025
PG 8
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA Y2Q5E
UT WOS:001430634800001
PM 39547323
DA 2025-06-11
ER

PT J
AU Enns, LC
   Morton, JF
   Mangalindan, RS
   McKnight, GS
   Schwartz, MW
   Kaeberlein, MR
   Kennedy, BK
   Rabinovitch, PS
   Ladiges, WC
AF Enns, Linda C.
   Morton, John F.
   Mangalindan, Ruby Sue
   McKnight, G. Stanley
   Schwartz, Michael W.
   Kaeberlein, Matt R.
   Kennedy, Brian K.
   Rabinovitch, Peter S.
   Ladiges, Warren C.
TI Attenuation of Age-Related Metabolic Dysfunction in Mice With a Targeted
   Disruption of the Cβ Subunit of Protein Kinase A
SO JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL
   SCIENCES
LA English
DT Article
DE Aging; PKA C beta; Metabolic syndrome; Obesity resistance; Insulin
   sensitivity
ID LIFE-SPAN EXTENSION; MESENTERIC FAT THICKNESS; INSULIN-RESISTANCE;
   CATALYTIC SUBUNIT; RESPONSE ELEMENT; BODY-WEIGHT; TRANSCRIPTION FACTOR;
   STRESS RESISTANCE; OXIDATIVE STRESS; GENE-EXPRESSION
AB The cyclic adenosine monophosphate-dependent protein kinase A (PKA) pathway helps regulate both cell growth and division, and triglyceride storage and metabolism in response to nutrient status. Studies in yeast show that disruption of this pathway promotes longevity in a manner similar to caloric restriction. Because PKA is highly conserved, it can be studied in mammalian systems. This report describes the metabolic phenotype of mice lacking the PKA catalytic subunit C beta. We confirmed that C beta has high levels of expression in the brain but also showed moderate levels in liver. C beta-null animals had reduced basal PKA activity while appearing overtly normal when fed standard rodent chow. However, the absence of C beta protected mice from diet-induced obesity, steatosis, dyslipoproteinemia, and insulin resistance, without any differences in caloric intake or locomotor activity. These findings have relevant pharmacological implications because aging in mammals is characterized by metabolic decline associated with obesity, altered body fat distribution, and insulin resistance.
C1 [Ladiges, Warren C.] Univ Washington, Sch Med, Dept Comparat Med, Seattle, WA 98915 USA.
   [McKnight, G. Stanley] Univ Washington, Dept Pharmacol, Seattle, WA 98915 USA.
   [Schwartz, Michael W.] Univ Washington, Dept Med, Seattle, WA 98915 USA.
   [Kaeberlein, Matt R.; Rabinovitch, Peter S.] Univ Washington, Dept Pathol, Seattle, WA 98915 USA.
   [Kennedy, Brian K.] Univ Washington, Dept Biochem, Seattle, WA 98915 USA.
C3 University of Washington; University of Washington Seattle; University
   of Washington; University of Washington Seattle; University of
   Washington; University of Washington Seattle; University of Washington;
   University of Washington Seattle; University of Washington; University
   of Washington Seattle
RP Ladiges, WC (corresponding author), Univ Washington, Sch Med, Dept Comparat Med, Seattle, WA 98915 USA.
EM Wladiges@u.washington.edu
RI Schwartz, Michael/H-9950-2012
OI Kennedy, Brian/0000-0002-5754-1874
FU Ellison Medical Foundation at the National Insititute on Aging (Nathan
   Shock Center); National Institute of Diabetes and Digestive and Kidney
   Diseases; National Institutes of Health
FX Supported in part by the Ellison Medical Foundation at the National
   Insititute on Aging (Nathan Shock Center) and at the National Institute
   of Diabetes and Digestive and Kidney Diseases, National Institutes of
   Health
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NR 60
TC 32
Z9 32
U1 0
U2 5
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1079-5006
EI 1758-535X
J9 J GERONTOL A-BIOL
JI J. Gerontol. Ser. A-Biol. Sci. Med. Sci.
PD DEC
PY 2009
VL 64
IS 12
BP 1221
EP 1231
DI 10.1093/gerona/glp133
PG 11
WC Geriatrics & Gerontology; Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA 516WI
UT WOS:000271573600003
PM 19776218
OA Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Larsen, JK
   van Ramshorst, B
   van Doornen, LJP
   Geenen, R
AF Larsen, Junilla K.
   van Ramshorst, Bert
   van Doornen, Lorenz J. P.
   Geenen, Rinie
TI Salivary Cortisol and Binge Eating Disorder in Obese Women After Surgery
   for Morbid Obesity
SO INTERNATIONAL JOURNAL OF BEHAVIORAL MEDICINE
LA English
DT Article
DE Salivary cortisol; Eating disorders; Obesity; Circadian rhythm; Cortisol
   awakening response; Binge eating
ID METABOLIC SYNDROME; STRESS; NEUROENDOCRINE; PATHOPHYSIOLOGY
AB Binge eating episodes characterized by loss of control are hypothesized to be accompanied by changes in hypothalamic pituitary adrenal (HPA) axis functioning. Cortisol is an end product of this neuroendocrine stress system.
   The aim of this study was to examine the cortisol levels and the awakening cortisol response (ACR) in obese persons showing binge eating after surgery for morbid obesity.
   Sixteen obese women with binge eating disorder (BED) and 18 obese women without BED participated in the study. Means +/- SD: age 43 +/- 15, body mass index 40 +/- 8. Salivary cortisol, anthropometric assessments, and the eating disorder examination interview were taken.
   Women with BED showed a significantly lower waist-to-hip ratio and cortisol levels during the day than women without BED, whereas the ACR did not differ.
   Our cross-sectional study in a small sample generates the hypothesis that neuroendocrine regulation differs between obese women with and without BED after obesity surgery. This finding needs replication in future studies that should also examine the causal direction of the observed association.
C1 [Larsen, Junilla K.] Radboud Univ Nijmegen, Inst Behav Sci, NL-6500 HE Nijmegen, Netherlands.
   [Larsen, Junilla K.; van Doornen, Lorenz J. P.; Geenen, Rinie] Univ Utrecht, Dept Clin & Hlth Psychol, Utrecht, Netherlands.
   [van Ramshorst, Bert] St Antonius Hosp, Dept Surg, Nieuwegein, Netherlands.
   [Geenen, Rinie] Univ Med Ctr Utrecht, Dept Rheumatol & Clin Immunol, Utrecht, Netherlands.
C3 Radboud University Nijmegen; Utrecht University; St. Antonius Hospital
   Utrecht; Utrecht University; Utrecht University Medical Center
RP Larsen, JK (corresponding author), Radboud Univ Nijmegen, Inst Behav Sci, POB 9104, NL-6500 HE Nijmegen, Netherlands.
EM j.larsen@pwo.ru.nl
RI Geenen, Rinie/G-3408-2012
OI Geenen, Rinie/0000-0002-6615-6708
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NR 22
TC 19
Z9 21
U1 0
U2 5
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1070-5503
EI 1532-7558
J9 INT J BEHAV MED
JI Int. J. Behav. Med.
PD DEC
PY 2009
VL 16
IS 4
BP 311
EP 315
DI 10.1007/s12529-009-9036-6
PG 5
WC Psychology, Clinical
WE Social Science Citation Index (SSCI)
SC Psychology
GA 531CF
UT WOS:000272639600002
PM 19288206
OA hybrid, Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Caldas, APS
   Chaves, LO
   Da Silva, LL
   Morais, DD
   Alfenas, RDG
AF Silva Caldas, Ana Paula
   Chaves, Larissa Oliveira
   Da Silva, Leticia Linhares
   Morais, Dayane De Castro
   Goncalves Alfenas, Rita de Cassia
TI Mechanisms involved in the cardioprotective effect of avocado
   consumption: A systematic review
SO INTERNATIONAL JOURNAL OF FOOD PROPERTIES
LA English
DT Review
DE Cardiovascular disease; Dyslipidemia; Inflammation; Oxidative stress;
   Persea americana
ID MONOUNSATURATED FATTY-ACIDS; CARDIOVASCULAR-DISEASE; INSULIN-RESISTANCE;
   OXIDATIVE STRESS; METABOLIC SYNDROME; LIPID-METABOLISM; DIETARY-FAT;
   HEALTH; RISK; INFLAMMATION
AB The objective of this review was to verify the effects of avocado consumption on cardiovascular diseases (CVDs) risk factors. A systematic search was conducted in electronic databases using the descriptor avocado, combined with CVD, monosaturated fat, antioxidant, lipoprotein, and inflammation, and their respective terms in Spanish. The review was carried out in pairs, following the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analysis) recommendations. Initially, 234 studies were identified. After selection, eight articles were included. All the studies were randomized, most were crossover studies, and involving adult subjects. Total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-c), triglycerides (TG), platelet aggregation, and apolipoproteins reductions; besides high-density lipoprotein-cholesterol (HDL-c) and serum lipid peroxidation increases; Ikappa-B protein (IkB-) protein preservation; and NF-kappa B (NFB) inactivation were observed. Thus, avocado consumption exerts a beneficial effect on CVDs prevention, which can be attributed to its monounsaturated fatty acids (MUFA) content, especially oleic fatty acid. However, there is no consensus on the amount of avocado needed to confer such benefits.
C1 [Silva Caldas, Ana Paula; Chaves, Larissa Oliveira; Da Silva, Leticia Linhares; Morais, Dayane De Castro; Goncalves Alfenas, Rita de Cassia] Univ Fed Vicosa, Dept Nutr & Hlth, Av PH Rolfs S-N, BR-36570900 Vicosa, MG, Brazil.
C3 Universidade Federal de Vicosa
RP Caldas, APS (corresponding author), Univ Fed Vicosa, Dept Nutr & Hlth, Av PH Rolfs S-N, BR-36570900 Vicosa, MG, Brazil.
EM paulacaldas06@hotmail.com
RI Chaves, Larissa/AAB-2281-2020; Morais, Dayane/GQH-8266-2022; Caldas, Ana
   Paula/E-8411-2017
OI Alfenas, Rita/0000-0003-2290-1611; Silva Caldas, Ana
   Paula/0000-0002-7517-3323
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NR 74
TC 15
Z9 17
U1 0
U2 27
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1094-2912
EI 1532-2386
J9 INT J FOOD PROP
JI Int. J. Food Prop.
PY 2017
VL 20
SU 2
BP 1675
EP 1685
DI 10.1080/10942912.2017.1352601
PG 11
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA FT9YF
UT WOS:000423507700041
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Hopper, MK
   Brown, GW
   Funke, KA
   Brown, LRP
AF Hopper, Mari K.
   Brown, Gordon W.
   Funke, Katharine A.
   Brown, Leslie R. Pike
TI Prevalence of Hyperinsulinemia Associated With Body Mass Index, Genetic
   Predisposition, and Lifestyle in College Freshmen Students
SO JOURNAL OF AMERICAN COLLEGE HEALTH
LA English
DT Article
DE clinical medicine; community health; health education; nutrition
ID INSULIN-RESISTANCE; WEIGHT-GAIN; METABOLIC SYNDROME; GLUCOSE-TOLERANCE;
   CENTRAL ADIPOSITY; PERCEIVED STRESS; FASTING INSULIN; DIETARY-INTAKE;
   YOUNG-ADULTS; EXERCISE
AB Objective: College lifestyle places an individual at greater risk for the development of insulin resistance (IR) and disease. The aim of this study was to establish a baseline measurement of insulin, and other variables influencing IR in college freshmen. Participants: Twenty-two men and women, 18 to 19 years of age, during first month of college. Methods: Following 12-hour fast, subjects reported to the laboratory for determination of body mass index (BMI) and completion of questionnaire determining ethnicity, family history, and patterns of diet, exercise, and stress. Blood samples were obtained and analyzed for glucose and insulin. Results: Mean insulin value for men (14.9 +/- 1.86 mu U/mL) was normal, and that for women (17.3 +/- 1.74 mu U/mL) was slightly elevated. When subjects were grouped by BMI, genetic predisposition, and summated lifestyle risk, fasting insulin values were significantly different. Eight of 22 subjects were hyperinsulinemic (insulin > 19 mu U/mL). Conclusion: Hyperinsulinemia is prevalent in this population and merits further investigation and intervention.
C1 [Hopper, Mari K.; Brown, Gordon W.; Funke, Katharine A.; Brown, Leslie R. Pike] Univ So Indiana, Dept Biol, Evansville, IN 47712 USA.
C3 University Southern Indiana
RP Hopper, MK (corresponding author), Univ So Indiana, Dept Biol, 8600 Univ Blvd, Evansville, IN 47712 USA.
EM mkhopper@usi.edu
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NR 63
TC 1
Z9 5
U1 0
U2 9
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 0744-8481
EI 1940-3208
J9 J AM COLL HEALTH
JI J. Am. Coll. Health
PY 2012
VL 60
IS 1
BP 27
EP 36
DI 10.1080/07448481.2011.562577
PG 10
WC Education & Educational Research; Public, Environmental & Occupational
   Health
WE Social Science Citation Index (SSCI)
SC Education & Educational Research; Public, Environmental & Occupational
   Health
GA 917XE
UT WOS:000302211100005
PM 22171727
DA 2025-06-11
ER

PT J
AU Glassman, I
   Le, N
   Asif, A
   Goulding, A
   Alcantara, CA
   Vu, A
   Chorbajian, A
   Mirhosseini, M
   Singh, M
   Venketaraman, V
   Clarke, R
   Tyagi, A
AF Glassman, Ira
   Le, Nghia
   Asif, Aamna
   Goulding, Anabel
   Alcantara, Cheldon Ann
   Vu, Annie
   Chorbajian, Abraham
   Mirhosseini, Mercedeh
   Singh, Manpreet
   Venketaraman, Vishwanath
   Clarke, Robert
   Tyagi, Abhishek
TI The Role of Obesity in Breast Cancer Pathogenesis
SO CELLS
LA English
DT Review
DE obesity; diabetes mellitus; breast cancer; glutathione; mTOR; leptin;
   BMI
ID BODY-MASS INDEX; ADIPOSE-TISSUE INFLAMMATION; INDUCED
   INSULIN-RESISTANCE; DIET-INDUCED OBESITY; BETA-CELL FAILURE; OXIDATIVE
   STRESS; METABOLIC SYNDROME; POSTMENOPAUSAL WOMEN; ANTAGONIST PEPTIDE;
   TAMOXIFEN RESPONSE
AB Research has shown that obesity increases the risk for type 2 diabetes mellitus (Type 2 DM) by promoting insulin resistance, increases serum estrogen levels by the upregulation of aromatase, and promotes the release of reactive oxygen species (ROS) by macrophages. Increased circulating glucose has been shown to activate mammalian target of rapamycin (mTOR), a significant signaling pathway in breast cancer pathogenesis. Estrogen plays an instrumental role in estrogen-receptor-positive breast cancers. The role of ROS in breast cancer warrants continued investigation, in relation to both pathogenesis and treatment of breast cancer. We aim to review the role of obesity in breast cancer pathogenesis and novel therapies mediating obesity-associated breast cancer development. We explore the association between body mass index (BMI) and breast cancer incidence and the mechanisms by which oxidative stress modulates breast cancer pathogenesis. We discuss the role of glutathione, a ubiquitous antioxidant, in breast cancer therapy. Lastly, we review breast cancer therapies targeting mTOR signaling, leptin signaling, blood sugar reduction, and novel immunotherapy targets.
C1 [Glassman, Ira; Le, Nghia; Asif, Aamna; Goulding, Anabel; Alcantara, Cheldon Ann; Vu, Annie; Chorbajian, Abraham; Mirhosseini, Mercedeh; Venketaraman, Vishwanath] Western Univ Hlth Sci, Coll Osteopath Med Pacific, Pomona, CA 91766 USA.
   [Singh, Manpreet] Corona Reg Med Ctr, Dept Emergency Med, Corona, CA 92882 USA.
C3 Western University of Health Sciences
RP Venketaraman, V (corresponding author), Western Univ Hlth Sci, Coll Osteopath Med Pacific, Pomona, CA 91766 USA.
EM nghia.le@westernu.edu; aamna.asif@westernu.edu;
   cheldonann.alcantara@westernu.edu; mercedeh.mirhosseini@westernu.edu;
   vvenketaraman@westernu.edu
RI Glassman, Ira/KHW-1866-2024; venketaraman, Vishwanath/AAW-6945-2020
OI venketaraman, Vishwanath/0000-0002-2586-1160; Glassman,
   Ira/0000-0001-5651-6282
FU Figures were created with BioRender.com
   (<uri>https://www.biorender.com</uri>).
FX Figures were created with BioRender.com
   (<URI>https://www.biorender.com</URI>).
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NR 192
TC 12
Z9 13
U1 4
U2 17
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2073-4409
J9 CELLS-BASEL
JI Cells
PD AUG
PY 2023
VL 12
IS 16
AR 2061
DI 10.3390/cells12162061
PG 24
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA Q1MV7
UT WOS:001055238000001
PM 37626871
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Molonia, MS
   Speciale, A
   Muscarà, C
   Salamone, FL
   Saija, A
   Cimino, F
AF Molonia, Maria Sofia
   Speciale, Antonio
   Muscara, Claudia
   Salamone, Federica Lina
   Saija, Antonella
   Cimino, Francesco
TI Low concentrations of α-lipoic acid reduce palmitic acid-induced
   alterations in murine hypertrophic adipocytes
SO NATURAL PRODUCT RESEARCH
LA English
DT Article
DE alpha-lipoic acid; adipocyte hypertrophy; inflammation; insulin
   resistance; oxidative stress; palmitic acid; 3T3-L1 adipocytes
ID NF-KAPPA-B; GLUCOSE-TRANSPORT; INSULIN-RESISTANCE; STIMULATION;
   ANTIOXIDANT; OBESITY; NRF2; TRANSCRIPTION; METABOLISM; MECHANISMS
AB Obesity is a metabolic disorder with excessive body fat accumulation, increasing incidence of chronic metabolic diseases. Hypertrophic obesity is associated with local oxidative stress and inflammation. Herein, we evaluated the in vitro activity of micromolar concentrations of a-lipoic acid (ALA) on palmitic acid (PA)exposed murine hypertrophic 3T3-L1 adipocytes, focussing on the main molecular pathways involved in adipogenesis, inflammation, and insulin resistance. ALA, starting from 1 mu M, decreased adipocytes hypertrophy, reducing PA-triggered intracellular lipid accumulation, PPAR-gamma levels, and FABP4 gene expression, and counteracted PA-induced intracellular ROS levels and NF-kappa B activation. ALA reverted PA-induced insulin resistance, restoring PI3K/ Akt axis and inducing GLUT-1 and glucose uptake, showing insulin sensitizing properties since it increased their basal levels. In conclusion, this study supports the potential effects of low micromolar ALA against hypertrophy, inflammation, and insulin resistance in adipose tissue, suggesting its important role as pharmacological supplement in the prevention of conditions linked to obesity and metabolic syndrome.
   [GRAPHICS]
C1 [Molonia, Maria Sofia; Speciale, Antonio; Muscara, Claudia; Salamone, Federica Lina; Saija, Antonella; Cimino, Francesco] Univ Messina, Dept Chem Biol Pharmaceut & Environm Sci, Messina, Italy.
   [Molonia, Maria Sofia] Univ Messina, Prof Antonio Imbesi Fdn, Messina, Italy.
C3 University of Messina; University of Messina
RP Speciale, A (corresponding author), Univ Messina, Dept Chem Biol Pharmaceut & Environm Sci, Messina, Italy.
EM specialea@unime.it
RI Speciale, Antonio/C-2846-2011; Cimino, Francesco/C-7036-2008; Molonia,
   Maria Sofia/IST-1982-2023; Muscara', Claudia/HPG-9442-2023
OI Salamone, Federica Lina/0000-0001-8923-2120; Muscara',
   Claudia/0000-0003-1815-1731
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NR 47
TC 3
Z9 3
U1 1
U2 3
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1478-6419
EI 1478-6427
J9 NAT PROD RES
JI Nat. Prod. Res.
PD MAR 18
PY 2024
VL 38
IS 6
BP 916
EP 925
DI 10.1080/14786419.2023.2207137
EA APR 2023
PG 10
WC Chemistry, Applied; Chemistry, Medicinal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Pharmacology & Pharmacy
GA IR0O9
UT WOS:000981509200001
PM 37129014
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Wang, YJ
   Liu, TT
   Xie, YM
   Li, N
   Liu, Y
   Wen, JQ
   Zhang, M
   Feng, WJ
   Huang, JB
   Guo, YX
   Kabbas, T Jr
   Wang, DX
   Granato, D
AF Wang, Yijun
   Liu, Tiantian
   Xie, Yanmei
   Li, Na
   Liu, Yan
   Wen, Jiaqiang
   Zhang, Man
   Feng, Wanjie
   Huang, Jinbao
   Guo, Yuanxin
   Kabbas, Tufy
   Wang, Dongxu
   Granato, Daniel
TI Clitoria ternatea blue petal extract protects against obesity, oxidative
   stress, and inflammation induced by a high-fat, high-fructose diet in
   C57BL/6 mice
SO FOOD RESEARCH INTERNATIONAL
LA English
DT Article
DE Anti -obesity; Reactive oxygen species; Flavonoids; Functional foods; In
   vivo study; Low-grade inflammation; Reverse cholesterol transport
ID FLOWER EXTRACT; DAMAGE; ANTHOCYANINS; ANTIOXIDANT; MACROPHAGES;
   RECEPTOR; IMPACT; COLOR
AB This study examined the chemical compounds and bioactivity of the aqueous extract of Clitoria ternatea blue petals and investigated its beneficial effects in vivo on a mouse model of obesity and metabolic syndrome. The extract mainly contained flavonoids, and nine compounds were tentatively identified. Male C57BL/6J mice were either fed a standard diet (SD) or a high-fat, high-fructose diet (HFFD) for 16 weeks, and HFFD-fed animals were treated with 0.25%, 0.5%, and 2% (w/w) of the aqueous extract in drinking water. The aqueous extract ameliorated oxidative stress and inflammation mediators. Furthermore, the aqueous extract reduced plasma leptin, free fatty acid, low-density lipoprotein cholesterol levels and hepatic malondialdehyde content. The aqueous extract significantly reduced total cholesterol and ameliorated insulin resistance. The results demonstrated that the aqueous extract of C. ternatea blue petals contains bioactive anthocyanins that exert substantial hypolipidemic and anti-inflammatory effects by promoting reverse cholesterol transport in HFFD-fed mice.
C1 [Wang, Yijun; Liu, Tiantian; Xie, Yanmei; Li, Na; Liu, Yan; Wen, Jiaqiang; Zhang, Man; Feng, Wanjie; Huang, Jinbao] Anhui Agr Univ, Sch Tea & Food Sci & Technol, State Key Lab Tea Plant Biol & Utilizat, Hefei 230036, Anhui, Peoples R China.
   [Guo, Yuanxin; Wang, Dongxu] Jiangsu Univ Sci & Technol, Sch Grain Sci & Technol, Zhenjiang 212003, Jiangsu, Peoples R China.
   [Kabbas, Tufy] State Univ Ponta Grossa UEPG, Grad Program Chem, Ave Carlos Cavalcanti, 4748, BR-84030900 Ponta Grossa, PR, Brazil.
   [Granato, Daniel] Univ Limerick, Fac Sci & Engn, Dept Biol Sci, Bioact & Applicat Lab, Limerick V94 T9PX, Ireland.
C3 Anhui Agricultural University; Jiangsu University of Science &
   Technology; Universidade Estadual de Ponta Grossa; University of
   Limerick
RP Wang, DX (corresponding author), Jiangsu Univ Sci & Technol, Sch Grain Sci & Technol, Zhenjiang 212003, Jiangsu, Peoples R China.; Granato, D (corresponding author), Univ Limerick, Fac Sci & Engn, Dept Biol Sci, Bioact & Applicat Lab, Limerick V94 T9PX, Ireland.
EM wdx@just.edu.cn; daniel.granato@ul.ie
RI Granato, Daniel/AAC-6151-2019; Li, Na/IXD-5170-2023; Huang,
   Jinbao/N-3391-2018
OI Granato, Daniel/0000-0002-4533-1597; Wang, Dongxu/0000-0001-7377-6190
FU Natural Science Foundation of Jiangsu Province;  [BK20210881]
FX This research was supported by the Natural Science Foundation of Jiangsu
   Province (BK20210881) . T. Kabbas Junior thanks the
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NR 53
TC 22
Z9 24
U1 4
U2 34
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0963-9969
EI 1873-7145
J9 FOOD RES INT
JI Food Res. Int.
PD DEC
PY 2022
VL 162
AR 112008
DI 10.1016/j.foodres.2022.112008
EA OCT 2022
PN A
PG 12
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA 5K1YD
UT WOS:000869527600001
PM 36461234
DA 2025-06-11
ER

PT J
AU Jawaid, A
   Jehle, KL
   Mansuy, IM
AF Jawaid, Ali
   Jehle, Katherina-Lynn
   Mansuy, Isabelle M.
TI Impact of Parental Exposure on Offspring Health in Humans
SO TRENDS IN GENETICS
LA English
DT Review
ID POSTTRAUMATIC-STRESS-DISORDER; BIRTH-WEIGHT; INTERGENERATIONAL
   TRANSMISSION; METABOLIC SYNDROME; MATERNAL EXPOSURE; HOLOCAUST; SMOKING;
   METHYLATION; INHERITANCE; OBESITY
AB The possibility that parental life experiences and environmental exposures influence mental and physical health across generations is an important concept in biology and medicine. Evidence from animal models has established the existence of a non-genetic mode of inheritance. This form of heredity involves transmission of the effects of parental exposure to the offspring through epigenetic changes in the germline. Studying the mechanisms of epigenetic inheritance in humans is challenging because it is difficult to obtain multigeneration cohorts, to collect reproductive cells in exposed parents, and to exclude psychosocial and cultural confounders. Nonetheless, epidemiological studies in humans exposed to famine, stress/trauma, or toxicants have provided evidence that parental exposure can impact the health of descendants, in some cases, across several generations. A few studies have also started to reveal epigenetic changes in the periphery and sperm after certain exposures. This article reviews these studies and evaluates the current evidence for the potential contribution of epigenetic factors to heredity in humans. The challenges and limitations of this fundamental biological process, its implications, and its societal relevance are also discussed.
C1 [Jawaid, Ali; Mansuy, Isabelle M.] Univ Zurich, Brain Res Inst, Lab Neuroepigenet, Med Fac, Zurich, Switzerland.
   [Jawaid, Ali; Mansuy, Isabelle M.] Swiss Fed Inst Technol, Dept Hlth Sci & Technol, Inst Neurosci, Zurich, Switzerland.
   [Jawaid, Ali] Nencki Inst Expt Biol, BRAINCITY EMBL Nencki Ctr Excellence Neural Plast, Warsaw, Poland.
   [Jawaid, Ali] Univ Texas Hlth Sci Ctr Houston, Dept Neurol, Houston, TX 77030 USA.
   [Jehle, Katherina-Lynn] Univ Zurich, Med Fac, Zurich, Switzerland.
C3 University of Zurich; Swiss Federal Institutes of Technology Domain; ETH
   Zurich; Polish Academy of Sciences; Nencki Institute of Experimental
   Biology of the Polish Academy of Sciences; University of Texas System;
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RP Mansuy, IM (corresponding author), Univ Zurich, Brain Res Inst, Lab Neuroepigenet, Med Fac, Zurich, Switzerland.; Mansuy, IM (corresponding author), Swiss Fed Inst Technol, Dept Hlth Sci & Technol, Inst Neurosci, Zurich, Switzerland.
EM mansuy@hifo.uzh.ch
RI Mansuy, Isabelle/N-3042-2015; Jawaid, Ali/KBQ-6269-2024
OI Mansuy, Isabelle M/0000-0001-7785-5371; Jawaid, Ali/0000-0002-5126-6744
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NR 95
TC 58
Z9 61
U1 4
U2 32
PU CELL PRESS
PI CAMBRIDGE
PA 50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA
SN 0168-9525
EI 1362-4555
J9 TRENDS GENET
JI Trends Genet.
PD APR
PY 2021
VL 37
IS 4
BP 373
EP 388
DI 10.1016/j.tig.2020.10.006
EA MAR 2021
PG 16
WC Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Genetics & Heredity
GA XO8IT
UT WOS:000730422900001
PM 33189388
DA 2025-06-11
ER

PT J
AU Vlavcheski, F
   Young, M
   Tsiani, E
AF Vlavcheski, Filip
   Young, Mariah
   Tsiani, Evangelia
TI Antidiabetic Effects of Hydroxytyrosol: In Vitro and In Vivo Evidence
SO ANTIOXIDANTS
LA English
DT Review
DE insulin resistance; diabetes; hydroxytyrosol; olive oil; phenols;
   antioxidant; antidiabetic
ID SERUM-CHOLESTEROL RESPONSE; ENDOPLASMIC-RETICULUM STRESS; INDUCED
   METABOLIC SYNDROME; BETA-CELL APOPTOSIS; OLIVE OIL PHENOLS;
   MEDITERRANEAN DIET; OXIDATIVE STRESS; RAT MODEL; OLEUROPEIN; TYPE-2
AB Insulin resistance, a pathological condition characterized by defects in insulin action leads to the development of Type 2 diabetes mellitus (T2DM), a disease which is currently on the rise that pose an enormous economic burden to healthcare systems worldwide. The current treatment and prevention strategies are considerably lacking in number and efficacy and therefore new targeted therapies and preventative strategies are urgently needed. Plant-derived chemicals such as metformin, derived from the French lilac, have been used to treat/manage insulin resistance and T2DM. Other plant-derived chemicals which are not yet discovered, may have superior properties to prevent and manage T2DM and thus research into this area is highly justifiable. Hydroxytyrosol is a phenolic phytochemical found in olive leaves and olive oil reported to have antioxidant, anti-inflammatory, anticancer and antidiabetic properties. The present review summarizes the current in vitro and in vivo studies examining the antidiabetic properties of hydroxytyrosol and investigating the mechanisms of its action.
C1 [Vlavcheski, Filip; Young, Mariah; Tsiani, Evangelia] Brock Univ, Dept Hlth Sci, St Catharines, ON L2S 3A1, Canada.
   [Vlavcheski, Filip; Tsiani, Evangelia] Brock Univ, Ctr Bone & Muscle Hlth, St Catharines, ON L2S 3A1, Canada.
C3 Brock University; Brock University
RP Tsiani, E (corresponding author), Brock Univ, Dept Hlth Sci, St Catharines, ON L2S 3A1, Canada.; Tsiani, E (corresponding author), Brock Univ, Ctr Bone & Muscle Hlth, St Catharines, ON L2S 3A1, Canada.
EM fvlavcheski@brocku.ca; my14ac@brocku.ca; ltsiani@brocku.ca
RI Vlavcheski, Filip/JFS-8649-2023
OI Tsiani, Evangelia/0000-0003-4218-5851; Vlavcheski,
   Filip/0000-0001-9615-1775
FU Natural Sciences and Engineering Research Council of Canada (NSERC)
FX This work was supported by a Natural Sciences and Engineering Research
   Council of Canada (NSERC) to E.T.
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NR 78
TC 40
Z9 43
U1 2
U2 27
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD JUN
PY 2019
VL 8
IS 6
DI 10.3390/antiox8060188
PG 20
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA II6FJ
UT WOS:000475288200040
PM 31234300
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Lanaspa, MA
   Sanchez-Lozada, LG
   Choi, YJ
   Cicerchi, C
   Kanbay, M
   Roncal-Jimenez, CA
   Ishimoto, T
   Li, NX
   Marek, G
   Duranay, M
   Schreiner, G
   Rodriguez-Iturbe, B
   Nakagawa, T
   Kang, DH
   Sautin, YY
   Johnson, RJ
AF Lanaspa, Miguel A.
   Sanchez-Lozada, Laura G.
   Choi, Yea-Jin
   Cicerchi, Christina
   Kanbay, Mehmet
   Roncal-Jimenez, Carlos A.
   Ishimoto, Takuji
   Li, Nanxing
   Marek, George
   Duranay, Murat
   Schreiner, George
   Rodriguez-Iturbe, Bernardo
   Nakagawa, Takahiko
   Kang, Duk-Hee
   Sautin, Yuri Y.
   Johnson, Richard J.
TI Uric Acid Induces Hepatic Steatosis by Generation of Mitochondrial
   Oxidative Stress POTENTIAL ROLE IN FRUCTOSE-DEPENDENT AND
   -INDEPENDENT FATTY LIVER
SO JOURNAL OF BIOLOGICAL CHEMISTRY
LA English
DT Article
ID BLOOD-PRESSURE; RISK-FACTOR; CELL-PROLIFERATION; DIETARY FRUCTOSE;
   FILTRATION-RATE; DISEASE; HYPERURICEMIA; ASSOCIATION; ALLOPURINOL;
   HOMEOSTASIS
AB Metabolic syndrome represents a collection of abnormalities that includes fatty liver, and it currently affects one-third of the United States population and has become a major health concern worldwide. Fructose intake, primarily from added sugars in soft drinks, can induce fatty liver in animals and is epidemiologically associated with nonalcoholic fatty liver disease in humans. Fructose is considered lipogenic due to its ability to generate triglycerides as a direct consequence of the metabolism of the fructose molecule. Here, we show that fructose also stimulates triglyceride synthesis via a purine-degrading pathway that is triggered from the rapid phosphorylation of fructose by fructokinase. Generated AMP enters into the purine degradation pathway through the activation of AMP deaminase resulting in uric acid production and the generation of mitochondrial oxidants. Mitochondrial oxidative stress results in the inhibition of aconitase in the Krebs cycle, resulting in the accumulation of citrate and the stimulation of ATP citrate lyase and fatty-acid synthase leading to de novo lipogeneis. These studies provide new insights into the pathogenesis of hepatic fat accumulation under normal and diseased states.
C1 [Cicerchi, Christina; Roncal-Jimenez, Carlos A.; Ishimoto, Takuji; Li, Nanxing; Nakagawa, Takahiko; Johnson, Richard J.] Univ Colorado, Dept Med, Div Renal Dis & Hypertens, Denver, CO 80045 USA.
   [Sanchez-Lozada, Laura G.] Inst Nacl Cardiol Ignacio Chavez, Dept Med, Lab Renal Physiopathol & Nephrol, Mexico City 14339, DF, Mexico.
   [Choi, Yea-Jin; Kang, Duk-Hee] Ewha Womans Univ, Sch Med, Dept Internal Med, Div Nephrol,Ehwa Med Res Ctr, Seoul 120750, South Korea.
   [Kanbay, Mehmet; Duranay, Murat] Kayseri Training & Res Hosp, Div Nephrol, Dept Med, TR-38039 Kayseri, Turkey.
   [Marek, George; Sautin, Yuri Y.] Univ Florida, Dept Med, Div Nephrol Hypertens & Transplantat, Gainesville, FL 32611 USA.
   [Schreiner, George] Cardero Therapeut Inc, Menlo Pk, CA 94085 USA.
   [Rodriguez-Iturbe, Bernardo] Inst Venezolano Invest Cient Zulia, Maracaibo 4001A, Venezuela.
   [Rodriguez-Iturbe, Bernardo] Univ Hosp, Maracaibo 4001A, Venezuela.
   [Rodriguez-Iturbe, Bernardo] Univ Zulia, Maracaibo 4001A, Venezuela.
C3 University of Colorado System; University of Colorado Denver; University
   of Colorado Anschutz Medical Campus; National Institute of Cardiology -
   Mexico; Ewha Womans University; Kayseri Training & Research Hospital;
   State University System of Florida; University of Florida
EM Miguel.lanaspagarcia@ucdenver.edu
RI Sanchez-Lozada, Laura/AAS-2104-2021; 1, 1/L-6277-2019; Lanaspa,
   Miguel/AAO-4971-2020; Duranay, Murat/HKV-1804-2023; Ishimoto,
   Takuji/M-4873-2014
OI Sanchez-Lozada, Laura-Gabriela/0000-0003-0348-9617; Duranay,
   Murat/0000-0002-2893-4484; Sautin, Yuri/0000-0003-3618-5134; Ishimoto,
   Takuji/0000-0002-9861-5331
FU National Institutes of Health [HL-68607, RC4 DK090869-01]; Amway;
   Cardero; Danone; Questcor; University of Colorado; Korea Healthcare
   Technology RAMP;D Project, Ministry for Health, Welfare, and Family
   Affairs, Republic of Korea Grant [A101742]
FX This work was supported, in whole or in part, by National Institutes of
   Health Grants HL-68607 and RC4 DK090869-01 (to R. J. J.). This work was
   also supported by Amway, Cardero, Danone, and Questcor (to R. J. J.) and
   by startup funds from the University of Colorado (to R. J. J.) and Korea
   Healthcare Technology R&D Project, Ministry for Health, Welfare, and
   Family Affairs, Republic of Korea Grant A101742 (to D.-H. K.). M. A. L.,
   T. I., and R. J. J. are listed as inventors on a patent application from
   the University of Colorado related to developing isoform-specific
   fructokinase inhibitors in the treatment of disorders associated with
   obesity and insulin resistance. T. N. and R. J. J. are listed as
   inventors on several patent applications related to lowering uric acid
   as a means to prevent or treat metabolic syndrome. Dr. Johnson also has
   a patent with the University of Washington and Merck for the use of
   allopurinol to treat hypertension. Dr. Johnson also discloses that he
   has consulted for Ardea, Astellas, Danone, and Novartis, that he is on
   the scientific board of Amway. R. J. J. and T. N. have patent
   applications related to lowering uric acid as a means to prevent fatty
   liver and metabolic syndrome. R. J. J., T. I., and M. L. also have
   patent applications related to blocking fructose metabolism as a means
   for preventing or treating metabolic syndrome. Dr. Johnson has also
   consulted for Novartis, Danone, Ardea, Mitsubishi Tanabe, and Astellas.
   Dr. Johnson also has two lay books on sugar, including the Sugar Fix
   (Rodale, 2008) and the Fat Switch (Mercola.com, 2012).
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NR 53
TC 575
Z9 616
U1 5
U2 80
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
EI 1083-351X
J9 J BIOL CHEM
JI J. Biol. Chem.
PD NOV 23
PY 2012
VL 287
IS 48
BP 40732
EP 40744
DI 10.1074/jbc.M112.399899
PG 13
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 042CM
UT WOS:000311448800062
PM 23035112
OA Green Published
DA 2025-06-11
ER

PT J
AU Watanabe, M
   Fuda, H
   Okabe, H
   Joko, S
   Miura, Y
   Hui, SP
   Yimin
   Hamaoka, N
   Miki, E
   Chiba, H
AF Watanabe, Mitsugu
   Fuda, Hirotoshi
   Okabe, Hiroaki
   Joko, Sae
   Miura, Yusuke
   Hui, Shu-Ping
   Yimin
   Hamaoka, Naohiro
   Miki, Emiko
   Chiba, Hitoshi
TI Oyster extracts attenuate pathological changes in non-alcoholic
   steatohepatitis (NASH) mouse model
SO JOURNAL OF FUNCTIONAL FOODS
LA English
DT Article
DE Pacific oyster; Obesity; Insulin resistance; Polyphenol; Antioxidant
ID FATTY LIVER-DISEASE; CULTURED HUMAN HEPATOCYTES; GREEN TEA POLYPHENOL;
   PHENOLIC ANTIOXIDANT; HEPATIC STEATOSIS; METABOLIC SYNDROME;
   CRASSOSTREA-GIGAS; OXIDATIVE STRESS; PPAR-GAMMA; CELL-DEATH
AB The phenolic compound 3,5-dihydroxy-4-methoxybenzyl alcohol (DHMBA) is a natural antioxidant recently isolated from the Pacific oyster. DHMBA, up to a concentration of 500 mu M, has demonstrated a strong in vitro hepatocyte-protective effect from oxidative stress without any cytotoxicity. This study investigated the in vivo potential of DHMBA-rich oyster extracts (DOE) for prevention or attenuation of non-alcoholic steatohepatitis (NASH). NASH-model mice, developed by supplementation of a high-fat diet for 23 weeks and intravenous injections of oxidised low-density lipoproteins, exhibited obesity, insulin resistance, hepatic steatosis, inflammation, fibrosis, and apoptosis. These changes were significantly moderated by supplementation of DOE. The search for an underlying mechanism determined that DOE significantly improved the redox status of DNA, proteins, and lipids. Moreover, DOE suppressed the increase of hepatic expression of PPARy and CD36 (fatty acid transporter) in the NASH-model mice. DOE might serve as a functional food for people at elevated risk for NASH. (C) 2015 The Authors. Published by Elsevier Ltd.
C1 [Watanabe, Mitsugu; Miki, Emiko] Watanabe Oyster Lab Co Ltd, 490-3 Shimoongata Cho, Hachioji, Tokyo 1920154, Japan.
   [Fuda, Hirotoshi; Okabe, Hiroaki; Joko, Sae; Miura, Yusuke; Hui, Shu-Ping; Chiba, Hitoshi] Hokkaido Univ, Fac Hlth Sci, Sapporo, Hokkaido 0600812, Japan.
   [Yimin] Hokkaido Univ, Grad Sch Med, Sapporo, Hokkaido 0608638, Japan.
   [Hamaoka, Naohiro] Hokkaido Res Org, Food Proc Res Ctr, Ebetsu, Hokkaido 0690836, Japan.
C3 Hokkaido University; Hokkaido University
RP Chiba, H (corresponding author), Hokkaido Univ, Fac Hlth Sci, Kita Ku, Kita 12,Nishi 5, Sapporo, Hokkaido 0600812, Japan.
EM chibahit@med.hokudai.ac.jp
FU Japan Society for the Promotion of Science [25450297]; Regional
   Innovation Strategy Support Program of the MEXT (Ministry of Education,
   Culture, Sports, Science, and Technology, Japan); Grants-in-Aid for
   Scientific Research [25450297] Funding Source: KAKEN
FX This work was financially supported by a Grant-in-Aid for Scientific
   Research from the Japan Society for the Promotion of Science (25450297)
   and by the Regional Innovation Strategy Support Program of the MEXT
   (Ministry of Education, Culture, Sports, Science, and Technology,
   Japan). We would like to thank Professor Ozaki for his advice in
   histopathological observation, and Dr. Seiji Takeda, Dr. Rojeet Shrestha
   and Dr. Takayuki Watanabe for their critical reading of the manuscript.
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NR 71
TC 17
Z9 17
U1 0
U2 35
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1756-4646
J9 J FUNCT FOODS
JI J. Funct. Food.
PD JAN
PY 2016
VL 20
BP 516
EP 531
DI 10.1016/j.jff.2015.11.029
PG 16
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA DL4VC
UT WOS:000375634900047
OA hybrid
DA 2025-06-11
ER

PT J
AU Salameh, TS
   Shah, GN
   Price, TO
   Hayden, MR
   Banks, WA
AF Salameh, Therese S.
   Shah, Gul N.
   Price, Tulin O.
   Hayden, Melvin R.
   Banks, William A.
TI Blood-Brain Barrier Disruption and Neurovascular Unit Dysfunction in
   Diabetic Mice: Protection with the Mitochondrial Carbonic Anhydrase
   Inhibitor Topiramate
SO JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
LA English
DT Article
ID MOUSE CEREBRAL PERICYTES; METABOLIC SYNDROME; PHARMACOLOGICAL
   INHIBITION; SYNAPTIC PLASTICITY; ALZHEIMERS-DISEASE; OXIDATIVE STRESS;
   RATS; PERMEABILITY; MELLITUS; INSULIN
AB All forms of diabetes mellitus are characterized by chronic hyperglycemia, resulting in the development of a number of microvascular and macrovascular pathologies. Diabetes is also associated with changes in brain microvasculature, leading to dysfunction and ultimately disruption of the blood-brain barrier (BBB). These changes are correlated with a decline in cognitive function. In diabetes, BBB damage is associated with increased oxidative stress and reactive oxygen species. This occurs because of the increased oxidative metabolism of glucose caused by hyperglycemia. Decreasing the production of bicarbonate with the use of a mitochondrial carbonic anhydrase inhibitor (mCAi) limits oxidative metabolism and the production of reactive oxygen species. In this study, we have demonstrated that 1) streptozotocin-induced diabetes resulted in BBB disruption, 2) ultrastructural studies showed a breakdown of the BBB and changes to the neurovascular unit (NVU), including a loss of brain pericytes and retraction of astrocytes, the two cell types that maintain the BBB, and 3) treatment with topiramate, a mCAi, attenuated the effects of diabetes on BBB disruption and ultrastructural changes in the neurovascular unit.
C1 [Salameh, Therese S.; Banks, William A.] Vet Affairs Puget Sound Hlth Care Syst, Educ & Clin Ctr, Geriatr Res, Seattle, WA USA.
   [Salameh, Therese S.; Banks, William A.] Univ Washington, Div Gerontol & Geriatr Med, Dept Med, Seattle, WA USA.
   [Shah, Gul N.; Price, Tulin O.] St Louis Univ, Sch Med, Div Endocrinol, Dept Internal Med, St Louis, MO USA.
   [Hayden, Melvin R.] Univ Missouri, Dept Internal Med, Div Endocrinol Diabet & Metab, Columbia, MO USA.
   [Hayden, Melvin R.] Univ Missouri, Diabet & Cardiovasc Res Lab, Columbia, MO USA.
C3 Geriatric Research Education & Clinical Center; US Department of
   Veterans Affairs; Veterans Health Administration (VHA); Vet Affairs
   Puget Sound Health Care System; University of Washington; University of
   Washington Seattle; Saint Louis University; University of Missouri
   System; University of Missouri Columbia; University of Missouri System;
   University of Missouri Columbia
RP Banks, WA (corresponding author), VAPSHCS, 810A-1,1660 S Columbian Way, Seattle, WA 98108 USA.
EM wabanks1@uw.edu
RI Banks, William/K-1330-2017
FU National Institutes of Health National Institute of Diabetes and
   Digestive and Kidney Diseases [RO1 DK083485]; Department of Veterans
   Affairs
FX This work was supported by the National Institutes of Health National
   Institute of Diabetes and Digestive and Kidney Diseases [Grant RO1
   DK083485] and the Department of Veterans Affairs.
CR Abrahám CS, 2002, CELL MOL NEUROBIOL, V22, P455, DOI 10.1023/A:1021067822435
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NR 34
TC 71
Z9 76
U1 0
U2 13
PU AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3995 USA
SN 0022-3565
EI 1521-0103
J9 J PHARMACOL EXP THER
JI J. Pharmacol. Exp. Ther.
PD DEC 1
PY 2016
VL 359
IS 3
BP 452
EP 459
DI 10.1124/jpet.116.237057
PG 8
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA EE4WH
UT WOS:000389605800008
PM 27729477
OA Green Published
DA 2025-06-11
ER

PT J
AU Dias, KKB
   de Jesus, GA
   da Costa, AAF
   Costa, FF
   da Rocha, GN
   Oliveira, RJ
   Noronha, RCR
   do Nascimento, LAS
AF Dias, Kaio Kelvin Barros
   de Jesus, Gabriel Araujo
   da Costa, Ana Alice Farias
   Costa, Fabiola Fernandes
   da Rocha Filho, Geraldo Narciso
   Oliveira, Rodrigo Juliano
   Noronha, Renata Coelho Rodrigues
   do Nascimento, Luis Adriano Santos
TI Biological activities from acai (Euterpe spp. Mart.) seeds and
   their pharmacological aspects: A systematic review and meta-analysis
SO PHARMANUTRITION
LA English
DT Article
DE Bioactive compounds; Bioeconomy; Amazon; Flavonoids; Health benefits;
   Pharmaceutical applications
ID OLERACEA MART.; HEPATIC STEATOSIS; OXIDATIVE STRESS; EXTRACT PREVENTS;
   INFLAMMATION; LUNG
AB Background: Acai seeds, a by-product of acai processing (1445 tons year(-1)), make up 85 % of the fruit's weight and are rich in phenolic compounds, such as phenolic acids, (epi)catechins, and procyanidins. Their chemical profile suggests significant pharmacological potential, leading to growing interest in their therapeutic applications.
   Methods: A systematic review was conducted following PRISMA guidelines, covering studies from 2006 to 2023.
   Results: The review included 72 studies, 13 of which were cluster randomized trials in rodents. Acai seed extract (ASE) displayed a robust phenolic profile with varying polymerization degrees. Preclinical investigations demonstrated ASE's therapeutic efficacy, showing potent antioxidant activities, upregulation of antioxidant enzymes via Nrf2 activation, and selective cytotoxicity against various cancer cell lines. ASE also exhibited efficacy in reducing oxidative stress, inflammatory cytokines, and inhibiting adipogenesis, addressing metabolic syndrome in rodents. Promising effects were observed on hypertension, hyperglycemia, dyslipidemia, and liver diseases, indicating broad health benefits.
   Conclusion: Despite study heterogeneity, ASE's shows potential as a therapeutic agent., necessitating further clinical investigations to comprehensively evaluate its safety and efficacy in human health.
C1 [Dias, Kaio Kelvin Barros; de Jesus, Gabriel Araujo; da Costa, Ana Alice Farias; Costa, Fabiola Fernandes; da Rocha Filho, Geraldo Narciso; do Nascimento, Luis Adriano Santos] Fed Univ Para, Amazon Oil Lab, BR-66075750 Belem, PA, Brazil.
   [Oliveira, Rodrigo Juliano] Univ Fed Mato Grosso do Sul UFMS, Fac Med FAMED, Ctr Estudos Celulas Tronco Terapia Celular & Genet, Campo Grande, MS, Brazil.
   [Oliveira, Rodrigo Juliano] Univ Fed Mato Grosso do Sul UFMS, Fac Med Dr Helio Mandetta FAMED, Programa Posgrad Saude & Desenvolvimento Regiao Ct, Campo Grande, MS, Brazil.
   [Noronha, Renata Coelho Rodrigues] Fed Univ Para, Inst Biol Sci, Ctr Adv Biodivers Studies, Lab Genect & Cellular Biol,GENBIOCEL, Augusto Correa St, BR-66075110 Belem, PA, Brazil.
C3 Universidade Federal do Para; Universidade Federal de Mato Grosso do
   Sul; Universidade Federal de Mato Grosso do Sul; Universidade Federal do
   Para
RP do Nascimento, LAS (corresponding author), Fed Univ Para, Amazon Oil Lab, BR-66075750 Belem, PA, Brazil.
EM kaiookelvin@gmail.com; gabriedejesus123@gmail.com;
   analilice@hotmail.com; fabiolaffc@yahoo.com.br; geraldonrf@gmail.com;
   rodrigo.oliveira@ufms.br; renatarcrn@gmail.com; adriansantos@ufpa.br
RI Filho, Geraldo/J-5464-2013; Oliveira, Rodrigo Juliano/M-3151-2018; de
   Jesus, Gabriel/IAN-1726-2023; NORONHA, RENATA/B-6376-2018; Nascimento,
   Luís/A-4615-2013
OI Araujo de Jesus, Gabriel/0000-0002-7187-3883
FU Banco da Amazonia [233/2022]; FAPESPA [073/2023]; CAPES; CNPQ
FX This work was supported by Banco da Amazonia [grant numbers 233/2022].
   FAPESPA [grant numbers 073/2023]. CAPES [Kaio, Gabriel and Ana Alice
   doctoral grants]. CNPQ [Luis Adriano, Renata, Rodrigo and Geraldo
   productivity grants].
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NR 76
TC 1
Z9 1
U1 2
U2 6
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2213-4344
J9 PHARMANUTRITION
JI PharmaNutrition
PD SEP
PY 2024
VL 29
AR 100405
DI 10.1016/j.phanu.2024.100405
EA AUG 2024
PG 25
WC Chemistry, Medicinal; Geriatrics & Gerontology; Gerontology; Nutrition &
   Dietetics; Pharmacology & Pharmacy
WE Emerging Sources Citation Index (ESCI)
SC Pharmacology & Pharmacy; Geriatrics & Gerontology; Nutrition & Dietetics
GA E9E7C
UT WOS:001305963800001
DA 2025-06-11
ER

PT J
AU Tao, GR
   Song, GH
   Qin, SC
AF Tao, Geru
   Song, Guohua
   Qin, Shucun
TI Molecular hydrogen: current knowledge on mechanism in alleviating free
   radical damage and diseases
SO ACTA BIOCHIMICA ET BIOPHYSICA SINICA
LA English
DT Review
DE molecular hydrogen; molecular mechanism; antioxidant; anti-inflammation;
   anti-apoptosis
ID NF-KAPPA-B; ENDOPLASMIC-RETICULUM STRESS; RICH WATER PROTECTS; ACUTE
   LUNG INJURY; OXIDATIVE STRESS; CELL-DEATH; ISCHEMIA/REPERFUSION INJURY;
   COGNITIVE IMPAIRMENT; NRF2 PATHWAY; FATTY LIVER
AB Ever since molecular hydrogen was first reported as a hydroxyl radical scavenger in 2007, the beneficial effect of hydrogen was documented in more than 170 disease models and human diseases including ischemia/reperfusion injury, metabolic syndrome, inflammation, and cancer. All these pathological damages are concomitant with overproduction of reactive oxygen species (ROS) where molecular hydrogen has been widely demonstrated as a selective antioxidant. Although it is difficult to construe the molecular mechanism of hydrogen's biomedical effect, an increasing number of studies have been helping us draw the picture clearer with days passing by. In this review, we summarized the current knowledge on systemic and cellular modulation by hydrogen treatment. We discussed the antioxidative, anti-inflammatory, and anti-apoptosis effects of hydrogen, as well as its protection on mitochondria and the endoplasmic reticulum, regulation of intracellular signaling pathways, and balancing of the immune cell subtypes. We hope that this review will provide organized information that prompts further investigation for in-depth studies of hydrogen effect.
C1 [Tao, Geru; Song, Guohua; Qin, Shucun] Shandong First Med Univ & Shandong Acad Med Sci, Inst Atherosclerosis, Key Lab Atherosclerosis Univ Shandong, Tai An 271000, Shandong, Peoples R China.
C3 Shandong First Medical University & Shandong Academy of Medical Sciences
RP Qin, SC (corresponding author), Shandong First Med Univ & Shandong Acad Med Sci, Inst Atherosclerosis, Key Lab Atherosclerosis Univ Shandong, Tai An 271000, Shandong, Peoples R China.
EM shucunqin@hotmail.com
RI Tao, Geru/HJJ-0866-2023
FU National Natural Science Foundation of China [81770855]; Taishan
   Scholars Foundation of Shandong Province [ts201511057]
FX This work was supported by the grants from the National Natural Science
   Foundation of China (No. 81770855) and the Taishan Scholars Foundation
   of Shandong Province (No. ts201511057).
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NR 108
TC 30
Z9 37
U1 3
U2 43
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1672-9145
EI 1745-7270
J9 ACTA BIOCH BIOPH SIN
JI Acta Biochim. Biophys. Sin.
PD DEC
PY 2019
VL 51
IS 12
BP 1189
EP 1197
DI 10.1093/abbs/gmz121
PG 9
WC Biochemistry & Molecular Biology; Biophysics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics
GA KF9EY
UT WOS:000509541900001
PM 31738389
OA Bronze
DA 2025-06-11
ER

PT J
AU Escobedo-Monge, MF
   Barrado, E
   Parodi-Román, J
   Escobedo-Monge, MA
   Torres-Hinojal, MC
   Marugán-Miguelsanz, JM
AF Escobedo-Monge, Marlene Fabiola
   Barrado, Enrique
   Parodi-Roman, Joaquin
   Escobedo-Monge, Maria Antonieta
   Torres-Hinojal, Maria Carmen
   Marugan-Miguelsanz, Jose Manuel
TI Copper/Zinc Ratio in Childhood and Adolescence: A Review
SO METABOLITES
LA English
DT Review
DE chronic diseases; zinc-to-copper ratio; inflammation; oxidative stress;
   nutritional status
ID OXIDATIVE STRESS; METABOLIC SYNDROME; TRACE-ELEMENTS; CHILDREN; ZINC;
   ASSOCIATION; EXPOSURES; NUTRITION; SEVERITY; DISEASE
AB Both copper (Cu) and zinc (Zn) are crucial micronutrients for human growth and development. This literature review covered the last five years of available evidence on the Cu/Zn ratio in children and adolescents. We searched PubMed, Web of Science, Google Scholar, Cochrane Library, and Science Direct for publications between 2017 and 2022, especially in English, although publications in other languages with abstracts in English were included. The main terms used were "copper", "zinc", "copper-zinc", and "zinc-copper" ratios. Cu and Zn determinations made in blood, plasma, or serum were included. This review comprises several cross-sectional and case-control studies with substantial results. The bibliographic search generated a compilation of 19 articles, in which 63.2% of the studies mostly reported a significantly higher Cu/Zn ratio, and 57.9% of them informed significantly lower levels of Zn. We conclude that children and adolescents with acute and chronic conditions are at greater risk of developing elevated Cu/Zn ratios, related to altered nutritional, infectious, and inflammatory status.
C1 [Escobedo-Monge, Marlene Fabiola; Torres-Hinojal, Maria Carmen] Univ Valladolid, Fac Med, Ave Ramon y Cajal 7, Valladolid 47005, Spain.
   [Barrado, Enrique] Univ Valladolid, Sci Fac, Dept Analyt Chem, Campus Miguel Delibes,Calle Paseo Belen 7, Valladolid 47011, Spain.
   [Parodi-Roman, Joaquin] Univ Cadiz, Sci Fac, Paseo Carlos III 28, Cadiz 11003, Spain.
   [Escobedo-Monge, Maria Antonieta] Univ Burgos, Sci Fac, Dept Chem, Plaza Misael Banuelos Sn, Burgos 09001, Spain.
   [Marugan-Miguelsanz, Jose Manuel] Univ Valladolid, Univ Clin Hosp Valladolid, Fac Med, Dept Pediat,Sect Gastroenterol & Pediat Nutr, Ave Ramon y Cajal 7, Valladolid 47005, Spain.
C3 Universidad de Valladolid; Universidad de Valladolid; Universidad de
   Cadiz; Universidad de Burgos; Universidad de Valladolid
RP Escobedo-Monge, MF (corresponding author), Univ Valladolid, Fac Med, Ave Ramon y Cajal 7, Valladolid 47005, Spain.
EM amescobedo@msn.com
RI ; ESCOBEDO MONGE, MARLENE FABIOLA/C-4830-2017
OI Marugan-Miguelsanz, Jose Manuel/0000-0001-7255-7578; ESCOBEDO MONGE,
   MARIA ANTONIETA/0000-0001-6318-7333; ESCOBEDO MONGE, MARLENE
   FABIOLA/0000-0002-1295-3752
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NR 98
TC 14
Z9 16
U1 0
U2 9
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2218-1989
J9 METABOLITES
JI Metabolites
PD JAN
PY 2023
VL 13
IS 1
AR 82
DI 10.3390/metabo13010082
PG 15
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 8Q5UB
UT WOS:000927270700001
PM 36677007
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Yaribeygi, H
   Zare, V
   Butler, AE
   Barreto, GE
   Sahebkar, A
AF Yaribeygi, Habib
   Zare, Vahid
   Butler, Alexandra E.
   Barreto, George E.
   Sahebkar, Amirhossein
TI Antidiabetic potential of saffron and its active constituents
SO JOURNAL OF CELLULAR PHYSIOLOGY
LA English
DT Review
DE crocin; Crocus sativus; diabetes mellitus; inflammation; insulin signal
   transduction; oxidative stress; saffron; safranal
ID NECROSIS-FACTOR-ALPHA; CROCUS-SATIVUS L.; OXIDATIVE STRESS;
   DIABETES-MELLITUS; INSULIN SENSITIVITY; INFLAMMATORY RESPONSE;
   MOLECULAR-MECHANISMS; METABOLIC SYNDROME; MEDICINAL-PLANTS; IN-VITRO
AB The prevalence of diabetes mellitus is growing rapidly worldwide. This metabolic disorder affects many physiological pathways and is a key underlying cause of a multitude of debilitating complications. There is, therefore, a critical need for effective diabetes management. Although many synthetic therapeutic glucose-lowering agents have been developed to control glucose homeostasis, they may have unfavorable side effects or limited efficacy. Herbal-based hypoglycemic agents present an adjunct treatment option to mitigate insulin resistance, improve glycemic control and reduce the required dose of standard antidiabetic medications. Saffron (Crocus sativus L.), whilst widely used as a food additive, is a natural product with insulin-sensitizing and hypoglycemic effects. Saffron contains several bioactive beta carotenes, which exert their pharmacological effects in various tissues without any obvious side effects. In this study, we discuss how saffron and its major components exert their hypoglycemic effects by induction of insulin sensitivity, improving insulin signaling and preventing beta-cell failure, all mechanisms combining to achieve better glycemic control.
C1 [Yaribeygi, Habib] Shahid Beheshti Univ Med Sci, Chron Kidney Dis Res Ctr, Tehran 1666677951, Iran.
   [Zare, Vahid] Baqiyatallah Univ Med Sci, Appl Microbiol Res Ctr, Tehran, Iran.
   [Butler, Alexandra E.] Qatar Biomed Res Inst, Diabet Res Ctr, Doha, Qatar.
   [Barreto, George E.] Pontificia Univ Javeriana, Fac Ciencias, Dept Nutr & Bioquim, Bogota, Colombia.
   [Barreto, George E.] Univ Autonoma Chile, Inst Ciencias Biomed, Santiago, Chile.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Neurogen Inflammat Res Ctr, Mashhad, Iran.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Biotechnol Res Ctr, Mashhad, Iran.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Sch Pharm, Mashhad, Iran.
C3 Shahid Beheshti University Medical Sciences; Baqiyatallah University of
   Medical Sciences (BMSU); Qatar Foundation (QF); Hamad Bin Khalifa
   University-Qatar; Qatar Biomedical Research Institute (QBRI); Pontificia
   Universidad Javeriana; Universidad Autonoma de Chile; Mashhad University
   of Medical Sciences; Mashhad University of Medical Sciences; Mashhad
   University of Medical Sciences
RP Yaribeygi, H (corresponding author), Shahid Beheshti Univ Med Sci, Chron Kidney Dis Res Ctr, Tehran 1666677951, Iran.; Sahebkar, A (corresponding author), Mashhad Univ Med Sci, Sch Med, Dept Med Biotechnol, POB 91779-48564, Mashhad, Iran.
EM habib.yari@yahoo.com; sahebkara@mums.ac.ir
RI Barreto, George E./LQJ-8882-2024; Sahebkar, Amirhossein/B-5124-2018;
   Zare, Vahid/AAG-1772-2019; Yaribeygi, Habib/R-8998-2019
OI Barreto, George E./0000-0002-6644-1971; Butler,
   Alexandra/0000-0002-5762-3917; Yaribeygi, Habib/0000-0002-1706-6212
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NR 94
TC 57
Z9 58
U1 0
U2 69
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0021-9541
EI 1097-4652
J9 J CELL PHYSIOL
JI J. Cell. Physiol.
PD JUN
PY 2019
VL 234
IS 6
BP 8610
EP 8617
DI 10.1002/jcp.27843
PG 8
WC Cell Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Physiology
GA HM2QU
UT WOS:000459314500080
PM 30515777
DA 2025-06-11
ER

PT J
AU Kumar, SR
   Narayan, B
   Sawada, Y
   Hosokawa, M
   Miyashita, K
AF Kumar, Sangeetha Ravi
   Narayan, Bhaskar
   Sawada, Yuki
   Hosokawa, Masashi
   Miyashita, Kazuo
TI Combined effect of astaxanthin and squalene on oxidative stress in vivo
SO MOLECULAR AND CELLULAR BIOCHEMISTRY
LA English
DT Article
DE Antioxidant enzymes; Astaxanthin; KK-A(y) mice; Lipid hydroperoxides;
   Squalene
ID INDUCED MYOCARDIAL-INFARCTION; CHOLESTEROL; ACID; OIL; PROFILE; CELLS;
   LIVER; MICE
AB Obesity and diabetes, risk factors for metabolic syndrome, are characterized by oxidative stress and inflammatory responses. Marine biofunctionals, astaxanthin (Ax) and squalene (SQ), were evaluated for their combined effect. Groups of male KK-A (y) mice were fed high fat/sucrose diet for 4 weeks, supplemented with either 0.1 %Ax, 2 %SQ or 0.1 %Ax + 2 %SQ. In comparison to control, Sod was elevated in only Ax + SQ. However, Gpx was highest in Ax + SQ, indicating the combined antioxidant effect of Ax and SQ. This was supported by elevated mRNA expression of Sod1 and Gpx1. Except adiponectin (elevated in Ax and Ax + SQ), expression of other inflammatory markers was not altered. Blood glucose levels were decreased in SQ and Ax + SQ while liver triglycerides decreased in SQ group. This is the first in vivo study demonstrating combined effects of Ax and SQ resulting in antioxidant effects and modulation of glucose/triglyceride levels. This study highlights the benefit of utilizing Ax and SQ together for management of obesity/diabetes.
C1 [Kumar, Sangeetha Ravi; Narayan, Bhaskar; Sawada, Yuki; Hosokawa, Masashi; Miyashita, Kazuo] Hokkaido Univ, Fac Fisheries Sci, 3-1-1 Minato Cho, Hakodate, Hokkaido 0418611, Japan.
   [Kumar, Sangeetha Ravi] Louisiana State Univ, Dept Pathobiol Sci, Lab Lung Biol, Baton Rouge, LA 70803 USA.
   [Kumar, Sangeetha Ravi] Louisiana State Univ, Ctr Expt Infect Dis Res, Baton Rouge, LA 70803 USA.
   [Narayan, Bhaskar] CSIR Cent Food Technol Res Inst, Dept Meat & Marine Sci, Mysore 570020, Karnataka, India.
C3 Hokkaido University; Louisiana State University System; Louisiana State
   University; Louisiana State University System; Louisiana State
   University; Council of Scientific & Industrial Research (CSIR) - India;
   CSIR - Central Food Technological Research Institute (CFTRI)
RP Kumar, SR; Miyashita, K (corresponding author), Hokkaido Univ, Fac Fisheries Sci, 3-1-1 Minato Cho, Hakodate, Hokkaido 0418611, Japan.; Kumar, SR (corresponding author), Louisiana State Univ, Dept Pathobiol Sci, Lab Lung Biol, Baton Rouge, LA 70803 USA.; Kumar, SR (corresponding author), Louisiana State Univ, Ctr Expt Infect Dis Res, Baton Rouge, LA 70803 USA.
EM sangeetha.rk@gmail.com; kmiya@fish.hokudai.ac.jp
RI Miyashita, Kazuo/C-4600-2012; Kumar, Sangeetha/L-4341-2014; Hosokawa,
   Masashi/C-3024-2008; Narayan, Bhaskar/B-8360-2008
OI Hosokawa, Masashi/0000-0003-1755-3173
FU Scientific technique research promotion program for agriculture,
   forestry, fisheries and food industry; National Project for the
   Formation of Tohoku Marine Science Center from MEXT (Ministry of
   Education, Culture, Sports, Science& Technology in Japan); Japan Society
   for Promotion of Science (JSPS)
FX This work was supported by "Scientific technique research promotion
   program for agriculture, forestry, fisheries and food industry'' and
   partially supported by a National Project for the Formation of Tohoku
   Marine Science Center from MEXT (Ministry of Education, Culture, Sports,
   Science& Technology in Japan). SRK and BN are grateful to Japan Society
   for Promotion of Science (JSPS) for Post-Doctoral Fellowship and
   Invitation Fellowship, respectively.
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NR 35
TC 27
Z9 28
U1 0
U2 21
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0300-8177
EI 1573-4919
J9 MOL CELL BIOCHEM
JI Mol. Cell. Biochem.
PD JUN
PY 2016
VL 417
IS 1-2
BP 57
EP 65
DI 10.1007/s11010-016-2713-2
PG 9
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA DO2ES
UT WOS:000377593300006
PM 27188184
DA 2025-06-11
ER

PT J
AU Marissal-Arvy, N
   Heliès, JM
   Tridon, C
   Moisan, MP
   Mormède, P
AF Marissal-Arvy, N.
   Helies, J. -M.
   Tridon, C.
   Moisan, M. -P.
   Mormede, P.
TI Quantitative Trait Loci Influencing Abdominal Fat Deposition and
   Functional Variability of the HPA Axis in the Rat
SO HORMONE AND METABOLIC RESEARCH
LA English
DT Article
DE QTL; metabolism; glucocorticoid; rat
ID GLUCOCORTICOID-RECEPTOR GENE; INSULIN-INDUCED HYPOGLYCEMIA; STRAIN
   DIFFERENCES; METABOLIC SYNDROME; HYPERTENSIVE-RATS; CHOLESTEROL;
   OBESITY; EXCRETION; STRESS; CORTICOSTERONE
AB With the aim to reveal common genomic regions influencing phenotypes related to HPA axis function and metabolism, we did a quantitative trait loci (QTL) study in a F2 population obtained from the cross-breeding between 2 contrasted rat strains, LOU/C and Fischer 344. QTL determining phenotypes related first to corticotropic function were searched: plasma corticosterone (Cort) in control and stress conditions, after a dexamethasone suppression treatment (glucocorticoid receptor related-effect), and mineralocorticoid receptor-mediated urinary response to aldosterone. Then, phenotypes related to metabolism were studied on the same animals: body composition, basal and post-insulin plasma glucose, plasma free fatty acids, leptin, and insulin. Finally, we analyzed the overlapping regions between these QTL and looked for candidate genes within these regions. The gene NR3C1 encoding the glucocorticoid receptor was confirmed to be central in the link between hypothalamic-pituitary-adrenal (HPA) axis function and fat deposition, and its metabolic consequences. Among the other candidate genes detected, most contain a glucocorticoid responsive element, strengthening our hypothesis of common genetic determinism between HPA axis and metabolism.
C1 [Marissal-Arvy, N.; Helies, J. -M.; Tridon, C.; Moisan, M. -P.; Mormede, P.] INRA, Lab Nutr & Integrat Neurobiol, Bordeaux, France.
   [Marissal-Arvy, N.; Helies, J. -M.; Tridon, C.; Moisan, M. -P.; Mormede, P.] Univ Bordeaux, Lab Nutr & Integrat Neurobiol, Bordeaux, France.
C3 INRAE; Universite de Bordeaux
RP Marissal-Arvy, N (corresponding author), Univ Bordeaux Segalen, INRA, UMR 1286, 146 Rue Leo Saignat, F-33076 Bordeaux, France.
EM nathalie.arvy@bordeaux.inra.fr
RI Marissal-Arvy, Nathalie/AAL-6103-2021; Mormede, Pierre/N-3918-2019;
   Moisan, Marie-Pierre/AAO-9971-2021; Mormede, Pierre/K-5537-2015
OI Marissal-Arvy, Nathalie/0000-0002-3147-5741; Moisan,
   Marie-Pierre/0000-0001-7315-5319; Mormede, Pierre/0000-0003-0345-1432
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Z9 4
U1 1
U2 7
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0018-5043
EI 1439-4286
J9 HORM METAB RES
JI Horm. Metab. Res.
PD AUG
PY 2014
VL 46
IS 9
BP 635
EP 643
DI 10.1055/s-0034-1383574
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA AO1UI
UT WOS:000341100000007
PM 25003539
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Mir, MM
   Jeelani, M
   Alharthi, MH
   Rizvi, SF
   Sohail, SK
   Wani, JI
   Ul Sabah, Z
   Binafif, WF
   Nandi, P
   Alshahrani, AM
   Alfaifi, J
   Jehangir, A
   Mir, R
AF Mir, Mohammad Muzaffar
   Jeelani, Mohammed
   Alharthi, Muffarah Hamid
   Rizvi, Syeda Fatima
   Sohail, Shahzada Khalid
   Wani, Javed Iqbal
   Ul Sabah, Zia
   Binafif, Waad Fuad
   Nandi, Partha
   Alshahrani, Abdullah M.
   Alfaifi, Jaber
   Jehangir, Adnan
   Mir, Rashid
TI Unraveling the Mystery of Insulin Resistance: From Principle Mechanistic
   Insights and Consequences to Therapeutic Interventions
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE insulin signaling; insulin resistance; signal transduction; T2DM;
   dyslipidemia; metabolic disease; lipotoxicity; inflammasome
ID PROTEIN-KINASE-C; ENDOPLASMIC-RETICULUM STRESS; RECEPTOR SUBSTRATE
   PROTEINS; EPITHELIUM-DERIVED FACTOR; CHRONIC KIDNEY-DISEASE;
   ADIPOSE-TISSUE; SKELETAL-MUSCLE; METABOLIC SYNDROME; DIABETES-MELLITUS;
   CRUCIAL ROLE
AB Insulin resistance (IR) is a significant factor in the development and progression of metabolic-related diseases like dyslipidemia, T2DM, hypertension, nonalcoholic fatty liver disease, cardiovascular and cerebrovascular disorders, and cancer. The pathogenesis of IR depends on multiple factors, including age, genetic predisposition, obesity, oxidative stress, among others. Abnormalities in the insulin-signaling cascade lead to IR in the host, including insulin receptor abnormalities, internal environment disturbances, and metabolic alterations in the muscle, liver, and cellular organelles. The complex and multifaceted characteristics of insulin signaling and insulin resistance envisage their thorough and comprehensive understanding at the cellular and molecular level. Therapeutic strategies for IR include exercise, dietary interventions, and pharmacotherapy. However, there are still gaps to be addressed, and more precise biomarkers for associated chronic diseases and lifestyle interventions are needed. Understanding these pathways is essential for developing effective treatments for IR, reducing healthcare costs, and improving quality of patient life.
C1 [Mir, Mohammad Muzaffar] Univ Bisha, Coll Med, Dept Clin Biochem, Bisha 61922, Saudi Arabia.
   [Jeelani, Mohammed] Univ Bisha, Coll Med, Dept Physiol, Bisha 61922, Saudi Arabia.
   [Alharthi, Muffarah Hamid; Nandi, Partha; Alshahrani, Abdullah M.] Univ Bisha, Coll Med, Dept Family & Community Med, Bisha 61922, Saudi Arabia.
   [Rizvi, Syeda Fatima; Sohail, Shahzada Khalid] Univ Bisha, Coll Med, Dept Pathol, Bisha 61922, Saudi Arabia.
   [Wani, Javed Iqbal; Ul Sabah, Zia] King Khalid Univ, Coll Med, Dept Internal Med, Abha 61421, Saudi Arabia.
   [Binafif, Waad Fuad] Univ Bisha, Coll Med, Dept Internal Med, Bisha 61922, Saudi Arabia.
   [Alfaifi, Jaber] Univ Bisha, Coll Med, Dept Child Hlth, Bisha 61922, Saudi Arabia.
   [Jehangir, Adnan] King Faisal Univ, Coll Med, Biomed Sci Dept, Al Hasa 31982, Saudi Arabia.
   [Mir, Rashid] Univ Tabuk, Fac Appl Med Sci, Prince Fahd Bin Sultan Res Chair, Dept MLT, Tabuk 71491, Saudi Arabia.
C3 University of Bisha; University of Bisha; University of Bisha;
   University of Bisha; King Khalid University; University of Bisha;
   University of Bisha; King Faisal University; University of Tabuk
RP Mir, MM (corresponding author), Univ Bisha, Coll Med, Dept Clin Biochem, Bisha 61922, Saudi Arabia.
EM mmmir@ub.edu.sa; mjeelani@ub.edu.sa; mualharthi@ub.edu.sa;
   sfatima@ub.edu.sa; sksohail@ub.edu.sa; drjiwani1959@gmail.com;
   drziaulsabah@gmail.com; waaeda@ub.edu.sa; partha@ub.edu.sa;
   jalfaifi@ub.edu.sa; amalik@kfu.edu.sa; rashidmirtabuk@gmail.com
RI Jeelani, Mohammed/JXW-6977-2024; Alshahrani, Abdullah/LQK-9226-2024;
   Wani, Javed/GSN-8466-2022; MIR, MOHAMMAD/AAN-4702-2020; Sohail,
   Shahzada/AAX-8729-2020; MIR, RASHID/AAH-1895-2019; Jaber,
   Alfaifi/JVO-8988-2024; sabah, Zia ul/HTP-1562-2023
OI , adnan jehangir malik/0009-0008-6819-4688; sabah, Zia
   ul/0000-0003-4473-7373; Mir, Rashid/0000-0002-4014-2332; sohail,
   shahzada/0000-0002-7286-8074
FU Deanship of Graduate Studies and Scientific Research at the University
   of Bisha
FX The authors are thankful to the Deanship of Graduate Studies and
   Scientific Research at the University of Bisha for supporting this work
   through the Fast-Track Research Support Program.
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NR 302
TC 0
Z9 0
U1 9
U2 9
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD MAR 19
PY 2025
VL 26
IS 6
AR 2770
DI 10.3390/ijms26062770
PG 49
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 0PH6R
UT WOS:001452794200001
PM 40141412
OA gold
DA 2025-06-11
ER

PT J
AU Jia, GHH
   Aroor, AR
   Sowers, JR
AF Jia, Guanghong
   Aroor, Annayya R.
   Sowers, James R.
TI The role of mineralocorticoid receptor signaling in the cross-talk
   between adipose tissue and the vascular wall
SO CARDIOVASCULAR RESEARCH
LA English
DT Review
DE Obesity; Adipocyte tissue; Mineralocorticoid receptors; Adipokines;
   Metabolic disorders; Cardiovascular disease
ID DIET-INDUCED OBESITY; NITRIC-OXIDE SYNTHASE; WESTERN DIET; DIASTOLIC
   DYSFUNCTION; ADIPOCYTE DYSFUNCTION; MACROPHAGE POLARIZATION;
   MYOCARDIAL-INFARCTION; METABOLIC SYNDROME; OXIDATIVE STRESS; CARDIAC
   FIBROSIS
AB Vascular dysfunction and impaired endothelial mediated relaxation are powerful underlying abnormalities in the pathogenesis of hypertension, coronary heart disease, and stroke. Obesity, type 2 diabetes mellitus, and other metabolic abnormalities are associated with activation of mineralocorticoid receptor (MRs) in the vasculature and adipose tissue. While MR signaling is involved in the normal physiological differentiation and maturation of adipocyte, enhanced activation of MRs also contributes to increase oxidative stress, release of pro-inflammatory adipokines, and dysregulation of adipocyte autophagy. This, in turn, increases the maladaptive expansion of subcutaneous, visceral and perivascular adipose tissue, resulting in systemic and cardiovascular (CV) insulin resistance and increased CV stiffness and impaired vascular and cardiac relaxation. This review summarizes the normal role of MR activation in adipose tissues and explores the mechanisms by which excessive MR activation mediates adipose tissue inflammation and vascular dysfunction. Potential preventative and therapeutic strategies directed in the prevention of MR activation and CV disease are also discussed.
C1 [Jia, Guanghong; Aroor, Annayya R.; Sowers, James R.] Univ Missouri, Sch Med, Diabet & Cardiovasc Ctr, Columbia, MO 65212 USA.
   [Jia, Guanghong; Aroor, Annayya R.; Sowers, James R.] Harry S Truman Mem Vet Hosp, Res Serv, 800 Hosp Dr, Columbia, MO 65212 USA.
   [Sowers, James R.] Univ Missouri, Sch Med, Dept Med Pharmacol & Physiol, Columbia, MO 65212 USA.
   [Sowers, James R.] Univ Missouri, Sch Med, Dalton Cardiovasc Res Ctr, Columbia, MO 65212 USA.
C3 University of Missouri System; University of Missouri Columbia; US
   Department of Veterans Affairs; Veterans Health Administration (VHA);
   Harry S. Truman Memorial Veterans' Hospital; University of Missouri
   System; University of Missouri Columbia; University of Missouri System;
   University of Missouri Columbia
RP Jia, GH; Sowers, JR (corresponding author), Univ Missouri, Diabet & Cardiovasc Ctr, Diabet Ctr HSC D109, One Hosp Dr, Columbia, MO 65212 USA.
EM jiag@health.missouri.edu; sowersj@health.missouri.edu
FU NIH [R01 HL73101-01A, R01 HL107910-01]; Veterans Affairs Merit System
   [0018]; American Diabetes Association [1-17-IBS-201]
FX J.R.S. received funding from NIH (R01 HL73101-01A and R01 HL107910-01)
   and the Veterans Affairs Merit System (0018). G.J. received funding from
   American Diabetes Association (Innovative Basic Science Award
   #1-17-IBS-201).
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NR 74
TC 51
Z9 54
U1 1
U2 8
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0008-6363
EI 1755-3245
J9 CARDIOVASC RES
JI Cardiovasc. Res.
PD JUL 15
PY 2017
VL 113
IS 9
BP 1055
EP 1063
DI 10.1093/cvr/cvx097
PG 9
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA FA5RG
UT WOS:000405500600007
PM 28838041
OA Bronze, Green Published
DA 2025-06-11
ER

EF﻿FN Clarivate Analytics Web of Science
VR 1.0
PT J
AU Son, Y
   Jang, MK
   Jung, MH
AF Son, Yonghae
   Jang, Min Kyung
   Jung, Myeong Ho
TI Vigna nakashimae Extract Prevents Hepatic Steatosis in Obese Mice
   Fed High-Fat Diets
SO JOURNAL OF MEDICINAL FOOD
LA English
DT Article
DE sterol regulatory element binding protein-1c; hepatic lipogenesis; Vigna
   nakashimae; nonalcoholic fatty liver disease; AMP-activated protein
   kinase
ID HOT-WATER EXTRACT; METABOLIC SYNDROME; OXIDATIVE STRESS; LIVER-DISEASE;
   ANGULARIS; POLYPHENOL; AMPK; LIPOGENESIS; RECEPTORS; PATHWAY
AB Vigna species are important food resources and are traditionally used for the treatment of various diseases. In this study, we examined the inhibitory effects of Vigna nakashimae (VN) extract on high-fat diet (HFD)-induced hepatic steatosis and elucidated the molecular mechanisms. C57BL/6J mice were fed an HFD with or without VN extract for 16 weeks. VN extract decreased HFD-induced body weight, liver weight, hepatic lipid accumulation, and plasma alanine aminotransferase, and suppressed oxidative stress and inflammation associated with hepatitis. VN extract decreased plasma lipid levels and the expression of lipogenic genes in the livers of HFD-fed mice. VN extract significantly increased phosphorylation of adenosine monophosphate (AMP)-activated protein kinase (AMPK) and acetyl-CoA carboxylase, and expression of fatty acid oxidation genes in the liver of VN-treated HFD mice and HepG2 cells. Further, VN extract inhibited insulin or glucose-stimulated lipogenesis in HepG2 cells. In conclusion, VN extract prevents HFD-induced hepatic steatosis and lipotoxicity through AMPK activation.
C1 [Son, Yonghae; Jang, Min Kyung; Jung, Myeong Ho] Pusan Natl Univ, Sch Korean Med, Yangsan Si 626770, Gyeongnam, South Korea.
C3 Pusan National University
RP Jung, MH (corresponding author), Pusan Natl Univ, Sch Korean Med, 30 Beom Eo Ri, Yangsan Si 626770, Gyeongnam, South Korea.
EM jung0603@pusan.ac.kr
RI Son, Yonghae/R-6194-2019
FU Globalization of Korean Foods R&D program - Ministry of Food,
   Agriculture, Forestry, and Fisheries, Republic of Korea; Research Fund
   Program of Research Institute for Basic Sciences, Pusan National
   University, Korea [RIBS-PNU-2011-00012180001]
FX This research was supported by the Globalization of Korean Foods R&D
   program, funded by the Ministry of Food, Agriculture, Forestry, and
   Fisheries, Republic of Korea (2012), and was supported by the Research
   Fund Program of Research Institute for Basic Sciences, Pusan National
   University, Korea, 2013, Project No. RIBS-PNU-2011-00012180001.
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NR 28
TC 9
Z9 9
U1 0
U2 8
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1096-620X
EI 1557-7600
J9 J MED FOOD
JI J. Med. Food
PD DEC 1
PY 2014
VL 17
IS 12
BP 1322
EP 1331
DI 10.1089/jmf.2014.3194
PG 10
WC Chemistry, Medicinal; Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Food Science & Technology; Nutrition &
   Dietetics
GA AU8DY
UT WOS:000345827800008
PM 25357150
DA 2025-06-11
ER

PT J
AU Kodaman, PH
   Duleba, AJ
AF Kodaman, Pinar H.
   Duleba, Antoni J.
TI Statins in the treatment of polycystic ovary syndrome
SO SEMINARS IN REPRODUCTIVE MEDICINE
LA English
DT Review
DE PCOS; statin; oxidative stress; insulin resistance; hyperandrogenemia;
   dyslipidemia; metabolic syndrome
ID GROWTH-FACTOR-I; THECA-INTERSTITIAL CELLS; NECROSIS-FACTOR-ALPHA;
   SMOOTH-MUSCLE-CELLS; LIPOPROTEIN LIPID CONCENTRATIONS; IMPAIRED
   GLUCOSE-TOLERANCE; GRADE CHRONIC INFLAMMATION; CORONARY-ARTERY DISEASE;
   ELEVATED SERUM-LEVELS; TERM-FOLLOW-UP
AB Polycystic ovary syndrome (PCOS) is the most common endocrinopathy affecting reproductive-aged women. The hyperandrogenemia associated with the syndrome is a result of excessive growth and steroldogenic activity of theca-interstitial tissues in response to various factors, including elevated gonadotropins, hyperinsulinemia, and oxidative stress. PCOS frequently coexists with other cardiovascular risk factors, such as dyslipidemia and systemic inflammation. Statins inhibit the synthesis of mevalonate, the key precursor to cholesterol biosynthesis, and reduce cardiovascular morbidity and mortality. Blockade of mevalonate production may also lead to decreased maturation of insulin receptors, inhibition of steroldogenesis (e.g., via limiting the amount of substrate: cholesterol), and alteration of signal transduction pathways that mediate cellular proliferation. The latter depend upon posttranslational modification of proteins (prenylation), a process mediated by mevalonate derivatives. Statins also have intrinsic antioxidant properties. Given the plelotropic actions of statins, they are likely not only to improve the dyslipidemia associated with PCOS but may also exert other beneficial metabolic and endocrine effects.
C1 [Duleba, Antoni J.] Univ Calif Davis, Dept Obstet & Gynecol, Div Reprod Endocrinol & Infertil, Sacramento, CA 95817 USA.
   [Kodaman, Pinar H.] Yale Univ, Sch Med, Dept Obstet Gynecol & Reprod Sci, Sect Reprod Endocrinol & Infertil, New Haven, CT USA.
C3 University of California System; University of California Davis; Yale
   University
RP Duleba, AJ (corresponding author), Univ Calif Davis, Dept Obstet & Gynecol, Div Reprod Endocrinol & Infertil, 4860 Y St,Suite 2500 ACC, Sacramento, CA 95817 USA.
EM Antoni.Duleba@ucdmc.ucdavis.edu
FU NICHD NIH HHS [R01 HD050656] Funding Source: Medline
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NR 119
TC 31
Z9 36
U1 0
U2 4
PU THIEME MEDICAL PUBL INC
PI NEW YORK
PA 333 SEVENTH AVE, NEW YORK, NY 10001 USA
SN 1526-8004
EI 1526-4564
J9 SEMIN REPROD MED
JI Semin. Reprod. Med.
PD JAN
PY 2008
VL 26
IS 1
BP 127
EP 138
DI 10.1055/s-2007-992933
PG 12
WC Obstetrics & Gynecology; Reproductive Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology; Reproductive Biology
GA 298ME
UT WOS:000255691000017
PM 18181091
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Riegersperger, M
   Covic, A
   Goldsmith, D
AF Riegersperger, Markus
   Covic, Adrian
   Goldsmith, David
TI Allopurinol, uric acid, and oxidative stress in cardiorenal disease
SO INTERNATIONAL UROLOGY AND NEPHROLOGY
LA English
DT Review
DE Allopurinol; Arterial hypertension; Cardiovascular disease; Chronic
   kidney disease; Diabetes mellitus; Heart disease; Hyperuricemia;
   Oxidative stress; Uric acid; Xanthine oxidase
ID CORONARY-ARTERY-DISEASE; CHRONIC KIDNEY-DISEASE; XANTHINE-OXIDASE
   ACTIVITY; BLOOD-PRESSURE; ENDOTHELIAL DYSFUNCTION; HYPERTENSIVE
   PATIENTS; RISK-FACTORS; METABOLIC SYNDROME; HEART-FAILURE; RENAL-DISEASE
AB In humans, the hepatic end product of purine metabolism is uric acid. Serum uric acid levels physiologically and gradually rise during human lifetime. Hyperuricemia also arises from excess dietary purine or ethanol intake, decreased renal excretion of uric acid, tumor lysis in lymphoma, leukemia or solid tumors, and sometimes pharmacotherapy. The definition of hyperuricemia is currently arbitrary. Hyperuricemia is associated with chronic kidney disease, arterial hypertension, coronary artery and heart disease, cerebrovascular disease and diabetes mellitus. Xanthine oxidase, a hepatic enzyme, catalyzes the production of uric acid, nitric oxide, and reactive oxygen species, which potentially damage deoxyribonucleic acid, ribonucleic acid and proteins, inactivate enzymes, oxidize amino acids and convert poly-unsaturated fatty acids to lipids. This is believed to contribute to atherosclerosis, endothelial dysfunction, renovascular hypertension, and cardiovascular disease. Xanthine oxidase inhibition efficiently blocks uric acid generation, and this improves glomerular filtration rates, systemic blood pressure, and cerebro-cardiovascular outcomes. Here, data from animal, in vivo, retro- and prospective, and interventional studies are reported.
C1 [Riegersperger, Markus] Med Univ Vienna, Div Nephrol & Dialysis, Dept Med 3, A-1090 Vienna, Austria.
   [Covic, Adrian] Parhon Hosp, Dept Nephrol, Grigore T Popa Sch Med & Pharm, Iasi, Romania.
   [Goldsmith, David] Guys & St Thomas Hosp, Renal & Transplantat Dept, London SE1 9RT, England.
C3 Medical University of Vienna; Grigore T Popa University of Medicine &
   Pharmacy; Guy's & St Thomas' NHS Foundation Trust
RP Riegersperger, M (corresponding author), Med Univ Vienna, Div Nephrol & Dialysis, Dept Med 3, Wahringer Gurtel 18-20, A-1090 Vienna, Austria.
EM markus.riegersperger@meduniwien.ac.at
RI Goldsmith, David/H-6965-2018; Covic, Adrian/G-5017-2016
OI Riegersperger, Markus/0000-0002-1151-9049; Goldsmith,
   David/0000-0002-4349-9193
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NR 100
TC 40
Z9 49
U1 0
U2 22
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0301-1623
EI 1573-2584
J9 INT UROL NEPHROL
JI Int. Urol. Nephrol.
PD JUN
PY 2011
VL 43
IS 2
BP 441
EP 449
DI 10.1007/s11255-011-9929-6
PG 9
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 763QA
UT WOS:000290573600024
PM 21547469
DA 2025-06-11
ER

PT J
AU Yamagishi, SI
   Matsui, T
   Nakamura, K
AF Yamagishi, Sho-ichi
   Matsui, Takanori
   Nakamura, Kazuo
TI Atheroprotective Properties of Pigment Epithelium-Derived Factor (PEDF)
   in Cardiometabolic Disorders
SO CURRENT PHARMACEUTICAL DESIGN
LA English
DT Review
DE Atherosclerosis; cardiometabolic disease; oxidative stress; PEDF
ID GLYCATION END-PRODUCTS; REACTIVE PROTEIN EXPRESSION; ENDOTHELIAL-CELLS;
   GENE-EXPRESSION; NADPH OXIDASE; OXIDATIVE STRESS; VASCULAR
   HYPERPERMEABILITY; METABOLIC SYNDROME; SERUM-LEVELS; IN-VITRO
AB Although remarkable therapeutic advances in the treatment of cardiometabolic disorders have been made with current therapeutic options, cardiovascular disease (CVD) is still a leading cause of mortality and morbidity in the Western world. Therefore, to develop a novel therapeutic strategy is needed for the prevention of cardiovascular disease (CVD) in high-risk patients for atherosclerosis. Recently, we, along with others, have shown that pigment epithelium-derived factor (PEDF), a glycoprotein with potent neuronal differentiating activity, exerts anti-oxidative and anti-inflammatory properties in vascular wall cells, leukocytes and platelets. In addition, PEDF not only suppresses neointimal hyperplasia after balloon angioplasty, but also blocks occlusive thrombus formation in a rat arterial thrombosis model. These observations suggest that substitution of PEDF may be a novel therapeutic strategy for atherosclerosis. This article summarizes the pathophysiological role of PEDF in atherosclerosis and its potential therapeutic implication in this devastating disorder. We also discuss here the kinetics and regulation of PEDF in cardiometabolic disorders in humans.
C1 [Yamagishi, Sho-ichi; Matsui, Takanori; Nakamura, Kazuo] Kurume Univ, Sch Med, Dept Pathophysiol & Therapeut Diabet Vasc Complic, Kurume, Fukuoka 8300011, Japan.
C3 Kurume University
RP Yamagishi, SI (corresponding author), Kurume Univ, Sch Med, Dept Pathophysiol & Therapeut Diabet Vasc Complic, Kurume, Fukuoka 8300011, Japan.
EM shoichi@med.kurume-u.ac.jp
OI Matsui, Takanori/0000-0001-9506-7571
FU Ministry of Education, Culture, Sports, Science and Technology, Japan
FX This work was supported in part by Grants of Collaboration with Venture
   Companies Project from the Ministry of Education, Culture, Sports,
   Science and Technology, Japan (S Yamagishi).
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NR 72
TC 48
Z9 49
U1 0
U2 4
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1381-6128
EI 1873-4286
J9 CURR PHARM DESIGN
JI Curr. Pharm. Design
PD MAR
PY 2009
VL 15
IS 9
BP 1027
EP 1033
DI 10.2174/138161209787581940
PG 7
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 415VK
UT WOS:000263964100011
PM 19275665
DA 2025-06-11
ER

PT J
AU Hussein, AA
   Ahmed, NA
   Sakr, HI
   Atia, T
   Ahmed, OM
AF Hussein, Aida A.
   Ahmed, Noha A.
   Sakr, Hader I.
   Atia, Tarek
   Ahmed, Osama M.
TI Omentin roles in physiology and pathophysiology: an up-to-date
   comprehensive review
SO ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
LA English
DT Review
DE Adipokines; omentin; diabetes mellitus; cardiovascular diseases;
   metabolic disorders; inflammation; rheumatic diseases; cancer
ID EPICARDIAL ADIPOSE-TISSUE; CORONARY-ARTERY-DISEASE; SERUM OMENTIN-1;
   INSULIN-RESISTANCE; RISK-FACTOR; TNF-ALPHA; CLINICOPATHOLOGICAL
   FEATURES; ENDOTHELIAL DYSFUNCTION; CAROTID ATHEROSCLEROSIS; INFLAMMATORY
   MARKERS
AB Omentin (intelectin) was first detected in the visceral omental adipose tissue. It has mainly two isoforms, omentin-1 and -2, with isoform-1 being the main form in human blood. It possesses insulin-sensitizing, anti-inflammatory, anti-atherogenic, cardio-protective, and oxidative stress-decreasing effects. Omentin's cardiovascular protective actions are caused by the improved endothelial cell survival and function, increased endothelial nitric oxide synthase (eNOS) and nitric oxide (NO) bioavailability, enhanced vascular smooth muscle cells (VSMCs) relaxation with reduced proliferation, decreased inflammation, and suppressed oxidative stress. Omentin may also have a potential role in different cancer types and rheumatic diseases. Thus, omentin is an excellent therapeutic target in many diseases, including diabetes mellitus (DM), metabolic syndrome (MetS), cardiovascular diseases (CVDs), inflammatory diseases, and cancer. This review demonstrates the physiological functions of omentin in ameliorating insulin resistance (IR), vascular function, and inflammation and its possible share in managing obesity-linked diseases, such as metabolic disorders, DM, and cardiovascular conditions.
C1 [Hussein, Aida A.] Suez Univ, Fac Sci, Zool Dept, Physiol Div, Suez, Egypt.
   [Ahmed, Noha A.; Ahmed, Osama M.] Beni Suef Univ, Fac Sci, Dept Zool, Physiol Div, Bani Suwayf, Egypt.
   [Sakr, Hader I.] Cairo Univ, Fac Med, Dept Med Physiol, Cairo, Egypt.
   [Sakr, Hader I.] Batterjee Med Coll, Dept Med Physiol, Gen Med Practice Program, Jeddah, Saudi Arabia.
   [Atia, Tarek] Prince Sattam Bin Abdulaziz Univ, Coll Appl Med Sci, Dept Med Lab Sci, Al Kharj, Saudi Arabia.
   [Atia, Tarek] Al Azhar Univ, Fac Med, Dept Histol, Cairo, Egypt.
   [Sakr, Hader I.] Cairo Univ, Kasr Al Aini Fac Med, Dept Med Physiol, Cairo, Egypt.
C3 Egyptian Knowledge Bank (EKB); Suez University; Egyptian Knowledge Bank
   (EKB); Beni Suef University; Egyptian Knowledge Bank (EKB); Cairo
   University; Batterjee Medical College; Prince Sattam Bin Abdulaziz
   University; Egyptian Knowledge Bank (EKB); Al Azhar University; Egyptian
   Knowledge Bank (EKB); Cairo University
RP Sakr, HI (corresponding author), Cairo Univ, Kasr Al Aini Fac Med, Dept Med Physiol, Cairo, Egypt.
EM hadersakr@kasralainy.edu.eg
RI Atia, Tarek/AAX-7326-2021; Sakr, Hader/AAC-1140-2022; Hussein,
   Aida/AAA-3934-2021; Ahmed, Osama/P-8126-2018
OI Hussein, Aida/0000-0002-9822-9086; Sakr, Hader/0000-0003-2917-2423;
   Atia, Tarek/0000-0001-6659-9173; Ahmed, Dr.Noha A./0000-0002-5080-0933
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NR 157
TC 9
Z9 9
U1 2
U2 11
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1381-3455
EI 1744-4160
J9 ARCH PHYSIOL BIOCHEM
JI Arch. Physiol. Biochem.
PD NOV 1
PY 2024
VL 130
IS 6
BP 800
EP 813
DI 10.1080/13813455.2023.2283685
EA NOV 2023
PG 14
WC Biochemistry & Molecular Biology; Biophysics; Endocrinology &
   Metabolism; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Endocrinology &
   Metabolism; Physiology
GA O5V8G
UT WOS:001107759200001
PM 37994431
DA 2025-06-11
ER

PT J
AU McCurdy, CE
   Schenk, S
   Hetrick, B
   Houck, J
   Drew, BG
   Kaye, S
   Lashbrook, M
   Bergman, BC
   Takahashi, DL
   Dean, TA
   Nemkov, T
   Gertsman, I
   Hansen, KC
   Philp, A
   Hevener, AL
   Chicco, AJ
   Aagaard, KM
   Grove, KL
   Friedman, JE
AF McCurdy, Carrie E.
   Schenk, Simon
   Hetrick, Byron
   Houck, Julie
   Drew, Brian G.
   Kaye, Spencer
   Lashbrook, Melanie
   Bergman, Bryan C.
   Takahashi, Diana L.
   Dean, Tyler A.
   Nemkov, Travis
   Gertsman, Ilya
   Hansen, Kirk C.
   Philp, Andrew
   Hevener, Andrea L.
   Chicco, Adam J.
   Aagaard, Kjersti M.
   Grove, Kevin L.
   Friedman, Jacob E.
TI Maternal obesity reduces oxidative capacity in fetal skeletal muscle of
   Japanese macaques
SO JCI INSIGHT
LA English
DT Article
ID HIGH-FAT DIET; TYPE-2 DIABETIC PARENTS; NONHUMAN PRIMATE MODEL;
   INSULIN-RESISTANCE; UNCOUPLING PROTEIN-3; MITOCHONDRIAL DYSFUNCTION;
   METABOLIC SYNDROME; LIPID OXIDATION; FUEL SELECTION; STRESS
AB Maternal obesity is proposed to alter the programming of metabolic systems in the offspring, increasing the risk for developing metabolic diseases; however, the cellular mechanisms remain poorly understood. Here, we used a nonhuman primate model to examine the impact of a maternal Western-style diet (WSD) alone, or in combination with obesity (Ob/WSD), on fetal skeletal muscle metabolism studied in the early third trimester. We find that fetal muscle responds to Ob/WSD by upregulating fatty acid metabolism, mitochondrial complex activity, and metabolic switches (CPT-1, PDK4) that promote lipid utilization over glucose oxidation. Ob/WSD fetuses also had reduced mitochondrial content, diminished oxidative capacity, and lower mitochondrial efficiency in muscle. The decrease in oxidative capacity and glucose metabolism was persistent in primary myotubes from Ob/WSD fetuses despite no additional lipid-induced stress. Switching obese mothers to a healthy diet prior to pregnancy did not improve fetal muscle mitochondrial function. Lastly, while maternal WSD alone led only to intermediary changes in fetal muscle metabolism, it was sufficient to increase oxidative damage and cellular stress. Our findings suggest that maternal obesity or WSD, alone or in combination, leads to programmed decreases in oxidative metabolism in offspring muscle. These alterations may have important implications for future health.
C1 [McCurdy, Carrie E.; Hetrick, Byron] Univ Oregon, Dept Human Physiol, Eugene, OR 97403 USA.
   [McCurdy, Carrie E.; Houck, Julie; Friedman, Jacob E.] Univ Colorado, Anschutz Med Campus, Dept Pediat, Aurora, CO USA.
   [Schenk, Simon] Univ Calif San Diego, Dept Orthopaed Surg, La Jolla, CA 92093 USA.
   [Drew, Brian G.; Hevener, Andrea L.] Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Div Endocrinol Diabet & Hypertens, Los Angeles, CA 90095 USA.
   [Drew, Brian G.] Baker IDI Heart & Diabet Inst, Diabet & Dyslipidaemia Lab, Prahran, Vic, Australia.
   [Kaye, Spencer; Lashbrook, Melanie; Chicco, Adam J.] Colorado State Univ, Dept Hlth & Exercise Sci, Ft Collins, CO 80523 USA.
   [Kaye, Spencer; Lashbrook, Melanie; Chicco, Adam J.] Colorado State Univ, Dept Biomed Sci, Ft Collins, CO 80523 USA.
   [Bergman, Bryan C.] Univ Colorado, Anschutz Med Campus, Dept Med, Div Endocrinol Metab & Diabet, Aurora, CO USA.
   [Takahashi, Diana L.; Dean, Tyler A.; Grove, Kevin L.] Oregon Natl Primate Res Ctr, Div Diabet Obes & Metab, Beaverton, OR USA.
   [Nemkov, Travis; Hansen, Kirk C.] Univ Colorado, Anschutz Med Campus, Dept Biochem & Mol Genet, Aurora, CO USA.
   [Gertsman, Ilya] Univ Calif San Diego, Dept Pediat, La Jolla, CA USA.
   [Philp, Andrew] Univ Birmingham, Sch Sport Exercise & Rehabil Sci, Birmingham B15 2TT, W Midlands, England.
   [Aagaard, Kjersti M.] Baylor Coll Med, Dept Obstet & Gynecol, Div Maternal Fetal Med, Houston, TX 77030 USA.
   [Aagaard, Kjersti M.] Texas Childrens Hosp, Houston, TX 77030 USA.
   [Grove, Kevin L.] Novo Nordisk Res Ctr, Seattle, WA USA.
C3 University of Oregon; University of Colorado System; University of
   Colorado Anschutz Medical Campus; University of California System;
   University of California San Diego; University of California System;
   University of California Los Angeles; University of California Los
   Angeles Medical Center; David Geffen School of Medicine at UCLA; Baker
   Heart and Diabetes Institute; Colorado State University System; Colorado
   State University Fort Collins; Colorado State University System;
   Colorado State University Fort Collins; University of Colorado System;
   University of Colorado Anschutz Medical Campus; Oregon Health & Science
   University; Oregon National Primate Research Center; University of
   Colorado System; University of Colorado Anschutz Medical Campus;
   University of California System; University of California San Diego;
   University of Birmingham; Baylor College of Medicine; Baylor College of
   Medicine; Baylor College Medical Hospital; Novo Nordisk
RP McCurdy, CE (corresponding author), 122c Esslinger Hall,1240 Univ Oregon, Eugene, OR 97403 USA.
EM cmccurd5@uoregon.edu
RI Nemkov, Travis/IST-8202-2023; Bergman, Bryan/T-8055-2019
OI Drew, Brian/0000-0002-7839-9467; Hetrick, Byron/0000-0002-3082-7338;
   Philp, Andrew/0000-0003-3860-4136; Schenk, Simon/0000-0002-8224-3203
FU NIAMS NIH HHS [P30 AR058878] Funding Source: Medline; NICHD NIH HHS [K12
   HD057022, R24 HD050837] Funding Source: Medline; NIDDK NIH HHS [P30
   DK063491, R01 DK109724, R24 DK090964, R01 DK089201] Funding Source:
   Medline; NIH HHS [P51 OD011092] Funding Source: Medline
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NR 80
TC 59
Z9 67
U1 2
U2 7
PU AMER SOC CLINICAL INVESTIGATION INC
PI ANN ARBOR
PA 2015 MANCHESTER RD, ANN ARBOR, MI 48104 USA
SN 2379-3708
J9 JCI INSIGHT
JI JCI Insight
PD OCT 6
PY 2016
VL 1
IS 16
AR e86612
DI 10.1172/jci.insight.86612
PG 17
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA EB1PC
UT WOS:000387124700001
PM 27734025
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Marzano, V
   Santini, S
   Rossi, C
   Zucchelli, M
   D'Alessandro, A
   Marchetti, C
   Mingardi, M
   Stagni, V
   Barilà, D
   Urbani, A
AF Marzano, Valeria
   Santini, Simonetta
   Rossi, Claudia
   Zucchelli, Mirco
   D'Alessandro, Annamaria
   Marchetti, Carlo
   Mingardi, Michele
   Stagni, Venturina
   Barila, Daniela
   Urbani, Andrea
TI Proteomic profiling of ATM kinase proficient and deficient cell lines
   upon blockage of proteasome activity
SO JOURNAL OF PROTEOMICS
LA English
DT Article
DE ATM kinase; Proteasome; Shotgun; Carbohydrate metabolism
ID DNA-DAMAGE RESPONSE; ATAXIA-TELANGIECTASIA GENE; DOUBLE-STRAND BREAKS;
   NF-KAPPA-B; OXIDATIVE STRESS; PROTEIN-KINASE; DEPENDENT PHOSPHORYLATION;
   METABOLIC SYNDROME; UBIQUITIN; ACTIVATION
AB Ataxia Telangiectasia Mutated (ATM) protein kinase is a key effector in the modulation of the functionality of some important stress responses, including DNA damage and oxidative stress response, and its deficiency is the hallmark of Ataxia Telangiectasia (A-T), a rare genetic disorder. ATM modulates the activity of hundreds of target proteins, essential for the correct balance between proliferation and cell death. The aim of this study is to evaluate the phenotypic adaptation at the protein level both in basal condition and in presence of proteasome blockage in order to identify the molecules whose level and stability are modulated through ATM expression. We pursued a comparative analysis of ATM deficient and proficient lymphoblastoid cells by label-free shotgun proteomic experiments comparing the panel of proteins differentially expressed. Through a non-supervised comparative bioinformatic analysis these data provided an insight on the functional role of ATM deficiency in cellular carbohydrate metabolism's regulation. This hypothesis has been demonstrated by targeted metabolic fingerprint analysis SRM (Selected Reaction Monitoring) on specific thermodynamic checkpoints of glycolysis. This article is part of a Special Issue entitled: Translational Proteomics. (C) 2012 Elsevier B.V. All rights reserved.
C1 [Marzano, Valeria; D'Alessandro, Annamaria; Marchetti, Carlo; Urbani, Andrea] Fdn Santa Lucia, Prote & Metabon Lab, I-00143 Rome, Italy.
   [Marzano, Valeria; D'Alessandro, Annamaria; Marchetti, Carlo; Urbani, Andrea] Univ Roma Tor Vergata, Dept Internal Med, I-00133 Rome, Italy.
   [Santini, Simonetta; Mingardi, Michele; Stagni, Venturina; Barila, Daniela] Fdn Santa Lucia, Lab Cell Signaling, I-00143 Rome, Italy.
   [Santini, Simonetta; Stagni, Venturina; Barila, Daniela] Univ Roma Tor Vergata, Dept Biol, I-00133 Rome, Italy.
   [Rossi, Claudia; Zucchelli, Mirco] Univ G DAnnunzio, Ctr Study Aging CeSI, I-66100 Chieti, Italy.
   [Rossi, Claudia; Zucchelli, Mirco] Univ G DAnnunzio, Dept Biomed Sci, I-66100 Chieti, Italy.
C3 IRCCS Santa Lucia; University of Rome Tor Vergata; IRCCS Santa Lucia;
   University of Rome Tor Vergata; G d'Annunzio University of
   Chieti-Pescara; G d'Annunzio University of Chieti-Pescara
RP Urbani, A (corresponding author), Fdn Santa Lucia, Prote & Metabon Lab, Via Fosso di Fiorano 64, I-00143 Rome, Italy.
EM andrea.urbani@uniroma2.it
RI Urbani, Andrea/AAD-1675-2022; BARILA', DANIELA/K-8506-2016; MARZANO,
   Valeria/K-5770-2016
OI BARILA', DANIELA/0000-0002-6192-1562; stagni,
   venturina/0000-0002-3971-0398; MARZANO, Valeria/0000-0001-6364-2121
FU Italian Telethon Foundation ("Comitato Telethon Fondazione Onlus")
   [GGP07252]; AIRC [IG10590]; Fondazione Roma, "Rete Nazionale di
   Proteomica" [FIRB RBRN07BMCT]
FX This study was supported by Italian Telethon Foundation ("Comitato
   Telethon Fondazione Onlus", GGP07252 to D.B. and A.U.) and in part by
   the following grants: AIRC IG10590 to D.B. and Fondazione Roma 2008,
   "Rete Nazionale di Proteomica" FIRB RBRN07BMCT to A.U.
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NR 64
TC 16
Z9 18
U1 0
U2 5
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1874-3919
EI 1876-7737
J9 J PROTEOMICS
JI J. Proteomics
PD AUG 3
PY 2012
VL 75
IS 15
BP 4632
EP 4646
DI 10.1016/j.jprot.2012.05.029
PG 15
WC Biochemical Research Methods
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 990CV
UT WOS:000307609500008
PM 22641158
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Hou, C
   Zhang, WM
   Li, JK
   Du, L
   Lv, O
   Zhao, SJ
   Li, J
AF Hou, Chen
   Zhang, Weimin
   Li, Jianke
   Du, Lin
   Lv, Ou
   Zhao, Shengjuan
   Li, Jia
TI Beneficial Effects of Pomegranate on Lipid Metabolism in Metabolic
   Disorders
SO MOLECULAR NUTRITION & FOOD RESEARCH
LA English
DT Review
DE lipid metabolism; metabolic disorders; mitochondria; pomegranate
ID FATTY LIVER-DISEASE; CANCER CHEMOPREVENTIVE ACTIVITIES; PUNICA-GRANATUM;
   PEEL POLYPHENOLS; OXIDATIVE STRESS; IN-VITRO; SEED OIL; MITOCHONDRIAL
   DYSFUNCTION; CHOLESTEROL ACCUMULATION; NLRP3 INFLAMMASOME
AB Pomegranate (Punica granatum Linn) is used in the prevention and treatment of metabolic syndrome in recent decades. Imbalances in lipid metabolism are profound features of metabolic disorders. In vivo and in vitro studies have shown that extracts of different pomegranate fractions (peels, flowers, juice, and seeds) regulate lipid metabolism in metabolic-disorder-associated diseases such as atherosclerosis, nonalcoholic fatty liver disease, and type 2 diabetes, helping to alleviate the development of diseases. Amelioration of oxidative stress and the inflammatory response is considered an important reason underlying the regulation of lipid metabolism by pomegranate extracts. Mitochondria, the major cellular site for lipid oxidation, are strongly associated with cellular oxidative and inflammatory status and are likely to be a target for pomegranate extract action. This review summarizes the main findings about the effects of different pomegranate fraction extracts on lipid metabolism in metabolic-disorder-associated diseases and analyses how pomegranate extracts achieve their effects. Furthermore, it also provides an important basis for the research and development of pomegranate-related nutrients or drugs.
C1 [Hou, Chen; Zhang, Weimin; Li, Jianke; Du, Lin; Lv, Ou; Zhao, Shengjuan; Li, Jia] Shaanxi Normal Univ, Coll Food Engn & Nutr Sci, Xian 710119, Shaanxi, Peoples R China.
   [Hou, Chen; Zhang, Weimin; Li, Jianke; Du, Lin; Lv, Ou; Zhao, Shengjuan; Li, Jia] Univ Key Lab Food Proc Byprod Adv Dev & High Valu, Xian 710119, Shaanxi, Peoples R China.
   [Li, Jianke] Natl Engn Lab Resource Dev Endangered Crude Drugs, Xian 710119, Shaanxi, Peoples R China.
   [Zhang, Weimin] Shaanxi Univ Chinese Med, Sch Publ Hlth, Xianyang 712046, Peoples R China.
C3 Shaanxi Normal University; Shaanxi University of Chinese Medicine
RP Li, JK (corresponding author), Shaanxi Normal Univ, Coll Food Engn & Nutr Sci, Xian 710119, Shaanxi, Peoples R China.; Li, JK (corresponding author), Univ Key Lab Food Proc Byprod Adv Dev & High Valu, Xian 710119, Shaanxi, Peoples R China.
EM jiankel@snnu.edu.cn
RI Zhang, weimin/AAT-2269-2020; HOU, CHEN/IQT-3648-2023
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NR 117
TC 78
Z9 79
U1 5
U2 101
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1613-4125
EI 1613-4133
J9 MOL NUTR FOOD RES
JI Mol. Nutr. Food Res.
PD AUG
PY 2019
VL 63
IS 16
SI SI
AR 1800773
DI 10.1002/mnfr.201800773
PG 12
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA IT6IB
UT WOS:000482974700003
PM 30677224
DA 2025-06-11
ER

PT J
AU Heeringa, M
   Hastings, A
   Yamazaki, S
   de Koning, P
AF Heeringa, Marten
   Hastings, Ann
   Yamazaki, Shunji
   de Koning, Paul
TI Serum biomarkers in nonalcoholic steatohepatitis: value for assessing
   drug effects?
SO BIOMARKERS IN MEDICINE
LA English
DT Review
DE apoptosis; biomarkers; cirrhosis; drug development; fatty liver;
   fibrosis; insulin resistance; NAFLD; NASH; nonalcoholic fatty liver
   disease; nonalcoholic steatohepatitis; oxidative stress; steatosis; Type
   2 diabetes
ID FATTY LIVER-DISEASE; C-REACTIVE PROTEIN; INSULIN-RESISTANCE; NONINVASIVE
   MARKERS; METABOLIC SYNDROME; HEPATIC STEATOSIS; HEPATOCYTE APOPTOSIS;
   OXIDATIVE STRESS; HYALURONIC-ACID; ANIMAL-MODEL
AB Nonalcoholic steatohepatitis (NASH) is a common chronic liver disease throughout the world. In the USA, approximately 3-5% of the population are affected, and the prevalence of this condition is increasing. NASH is associated with an increased risk of liver-related morbidity, such as cirrhosis and fibrosis, as well as cardiovascular disease, and in spite of several clinical studies investigating putative new drugs, no approved treatment is currently available. This is partly due to the nature of the disease. NASH is a complex, slowly progressing disease, and confirmatory clinical trials have long treatment durations and require invasive end points (a liver biopsy). Such invasive assessments are only accepted in confirmatory trials; clinical studies in the exploratory clinical development phase must rely on noninvasive biomarkers as the primary end point. Experimental and clinical research continues to achieve validation and qualification of biomarkers in NASH, which will hopefully assist the development of new treatments for NASH patients.
C1 [Heeringa, Marten; de Koning, Paul] Astellas Pharma Global Dev Europe, Global Clin Pharmacol & Exploratory Dev, NL-2353 EW Leiderdorp, Netherlands.
   [Hastings, Ann] Appl Pharmacol Res Labs, NL-2353 EW Leiderdorp, Netherlands.
   [Yamazaki, Shunji] Astellas Pharma Inc, Appl Pharmacol Res Labs, Tsukuba, Ibaraki, Japan.
C3 Astellas Pharmaceuticals; Astellas Pharmaceuticals
RP Heeringa, M (corresponding author), Astellas Pharma Global Dev Europe, Global Clin Pharmacol & Exploratory Dev, Elisabethhof 1, NL-2353 EW Leiderdorp, Netherlands.
EM marten.heeringa@astellas.com
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NR 87
TC 8
Z9 9
U1 0
U2 5
PU FUTURE MEDICINE LTD
PI LONDON
PA UNITEC HOUSE, 3RD FLOOR, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON, N3
   1QB, ENGLAND
SN 1752-0363
EI 1752-0371
J9 BIOMARK MED
JI Biomark. Med.
PD DEC
PY 2012
VL 6
IS 6
BP 743
EP 757
DI 10.2217/BMM.12.87
PG 15
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 055LA
UT WOS:000312416600006
PM 23227839
DA 2025-06-11
ER

PT S
AU Parrott, MD
   Greenwood, CE
AF Parrott, Matthew D.
   Greenwood, Carol E.
BE Weller, NJ
   Rattan, SIS
TI Dietary influences on cognitive function with aging - From high-fat
   diets to healthful eating
SO HEALTHY AGING AND LONGEVITY
SE Annals of the New York Academy of Sciences
LA English
DT Article; Proceedings Paper
CT 3rd International Conference on Healthy Aging and Longevity
CY OCT 13-15, 2006
CL Melbourne, AUSTRALIA
DE diet; dietary fat; cognition; memory; aging; insulin resistance; type 2
   diabetes mellitus; inflammation; neuroinflammation; Alzheimer's disease
ID INCIDENT ALZHEIMER-DISEASE; DOCOSAHEXAENOIC ACID; METABOLIC SYNDROME;
   INSULIN-RESISTANCE; BLUEBERRY SUPPLEMENTATION; GLUCOSE-CONCENTRATION;
   MEMORY IMPAIRMENT; OXIDATIVE STRESS; GENE-EXPRESSION; CELL-SURVIVAL
AB Human epidentiologic studies provide convincing evidence that dietary patterns practiced during adulthood are important contributors to age-related cognitive decline and dementia risk. Diets high in fat, especially trans and saturated fats, adversely affect cognition, while those high in fruits, vegetables, cereals, and fish are associated with better cognitive function and lower risk of dementia. While the precise physiologic mechanisms underlying these dietary influences are not completely understood, modulation of brain insulin activity and neuroinflammation likely contribute. Not surprisingly, deficits in cognitive functions, especially those dependent on the medial temporal lobes, are apparent in type 2 diabetes mellitus (T2DM). Special care in food selection at meals should be exercised by those with T2DM since ingestion of rapidly absorbed, high-glycemic index carbohydrate foods further impairs medial temporal lobe function, with food-induced increases in oxidative stress and cytokine release likely explaining the association between food ingestion and reduction in cognitive function in those with T2DM.
C1 [Parrott, Matthew D.; Greenwood, Carol E.] Univ Toronto, Fac Med, Dept Nutr Sci, Toronto, ON M5S 3E2, Canada.
   [Parrott, Matthew D.; Greenwood, Carol E.] Kunin Lunenfeld Appl Res Unit, Toronto, ON, Canada.
   [Greenwood, Carol E.] Food & Nutr Sci, Toronto, ON, Canada.
C3 University of Toronto
RP Greenwood, CE (corresponding author), Univ Toronto, Fac Med, Dept Nutr Sci, Toronto, ON M5S 3E2, Canada.
EM carol.greenwood@utoronto.ca
RI Greenwood, Carol/H-9978-2013
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NR 63
TC 74
Z9 86
U1 1
U2 39
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN STREET, MALDEN 02148, MA USA
SN 0077-8923
BN 978-1-57331-680-4
J9 ANN NY ACAD SCI
JI Ann.NY Acad.Sci.
PY 2007
VL 1114
BP 389
EP 397
DI 10.1196/annals.1396.028
PG 9
WC Geriatrics & Gerontology; Multidisciplinary Sciences; Physiology
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology; Science & Technology - Other Topics;
   Physiology
GA BHA05
UT WOS:000251775900043
PM 17986600
DA 2025-06-11
ER

PT J
AU Martiniakova, M
   Kovacova, V
   Mondockova, V
   Zemanova, N
   Babikova, M
   Biro, R
   Ciernikova, S
   Omelka, R
AF Martiniakova, Monika
   Kovacova, Veronika
   Mondockova, Vladimira
   Zemanova, Nina
   Babikova, Martina
   Biro, Roman
   Ciernikova, Sona
   Omelka, Radoslav
TI Honey: A Promising Therapeutic Supplement for the Prevention and
   Management of Osteoporosis and Breast Cancer
SO ANTIOXIDANTS
LA English
DT Review
DE honey; osteoporosis; breast cancer; associations; preclinical studies;
   clinical trials; prevention; management; treatment
ID OXIDATIVE STRESS; TUALANG HONEY; OSTEOCLAST DIFFERENTIATION;
   NITRIC-OXIDE; METABOLIC SYNDROME; BONE HEALTH; APOPTOSIS; EXPRESSION;
   LIGAND; CELLS
AB Osteoporosis and breast cancer are serious diseases that have become a significant socioeconomic burden. There are biochemical associations between the two disorders in terms of the amended function of estrogen, receptor activator of nuclear factor kappa beta ligand, oxidative stress, inflammation, and lipid accumulation. Honey as a functional food with high antioxidant and anti-inflammatory properties can contribute to the prevention of various diseases. Its health benefits are mainly related to the content of polyphenols. This review aims to summarize the current knowledge from in vitro, animal, and human studies on the use of honey as a potential therapeutic agent for osteoporosis and breast cancer. Preclinical studies have revealed a beneficial impact of honey on both bone health (microstructure, strength, oxidative stress) and breast tissue health (breast cancer cell proliferation and apoptosis, tumor growth rate, and volume). The limited number of clinical trials, especially in osteoporosis, indicates the need for further research to evaluate the potential benefits of honey in the treatment. Clinical studies related to breast cancer have revealed that honey is effective in increasing blood cell counts, interleukin-3 levels, and quality of life. In summary, honey may serve as a prospective therapeutic supplement for bone and breast tissue health.
C1 [Martiniakova, Monika; Kovacova, Veronika; Biro, Roman] Constantine Philosopher Univ Nitra, Fac Nat Sci & Informat, Dept Zool & Anthropol, Nitra 94901, Slovakia.
   [Mondockova, Vladimira; Zemanova, Nina; Babikova, Martina; Omelka, Radoslav] Constantine Philosopher Univ Nitra, Fac Nat Sci & Informat, Dept Bot & Genet, Nitra 94901, Slovakia.
   [Ciernikova, Sona] Slovak Acad Sci, Canc Res Inst, Biomed Res Ctr, Dept Genet, Bratislava 84505, Slovakia.
C3 Constantine the Philosopher University in Nitra; Constantine the
   Philosopher University in Nitra; Slovak Academy of Sciences; Biomedical
   Research Center, SAS; Cancer Research Institute, SAS
RP Martiniakova, M (corresponding author), Constantine Philosopher Univ Nitra, Fac Nat Sci & Informat, Dept Zool & Anthropol, Nitra 94901, Slovakia.; Omelka, R (corresponding author), Constantine Philosopher Univ Nitra, Fac Nat Sci & Informat, Dept Bot & Genet, Nitra 94901, Slovakia.
EM mmartiniakova@ukf.sk; romelka@ukf.sk
RI Martiniakova, Monika/AAC-2775-2019; Babikova, Martina/ABA-1524-2021;
   Ciernikova, Sona/ABB-3569-2021; Kováčová, Veronika/AAC-4522-2020;
   Mondockova, Vladimira/L-1570-2018; Zemanová, Nina/AGV-9716-2022; Omelka,
   Radoslav/A-6248-2019
OI Martiniakova, Monika/0000-0003-1889-026X; Kovacova,
   Veronika/0000-0002-8491-0399; Babikova, Martina/0000-0001-9156-5768;
   Omelka, Radoslav/0000-0002-6493-9880; Ciernikova,
   Sona/0000-0002-8139-6945; Mondockova, Vladimira/0000-0002-7186-4282
FU Ministry of Education, Science, Research and Sport of the Slovak
   Republic [VEGA 1/0444/20, KEGA 012UKF-4/2023]
FX This work was supported by the Ministry of Education, Science, Research
   and Sport of the Slovak Republic, grant number VEGA 1/0444/20 and KEGA
   012UKF-4/2023.
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NR 130
TC 11
Z9 11
U1 2
U2 7
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD MAR
PY 2023
VL 12
IS 3
AR 567
DI 10.3390/antiox12030567
PG 15
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA A1QG5
UT WOS:000952940100001
PM 36978815
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Szalabska-Rapala, K
   Borymska, W
   Kaczmarczyk-Sedlak, I
AF Szalabska-Rapala, Katarzyna
   Borymska, Weronika
   Kaczmarczyk-Sedlak, Ilona
TI Effectiveness of Magnolol, a Lignan from Magnolia Bark, in Diabetes, Its
   Complications and Comorbidities-A Review
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE magnolol; lignan; diabetes; diabetic complications; plant-derived
   polyphenols; antidiabetic potential
ID HIGH-FAT DIET; PANCREATIC BETA-CELLS; GROWTH-FACTOR-BETA; PIGMENT
   EPITHELIAL-CELLS; GLYCATION END-PRODUCTS; OXIDATIVE STRESS;
   INSULIN-RESISTANCE; PERIODONTAL-DISEASE; METABOLIC SYNDROME; KIOM-4
   PROTECTS
AB Diabetes mellitus is a chronic metabolic disease characterized by disturbances in carbohydrate, protein, and lipid metabolism, often accompanied by oxidative stress. Diabetes treatment is a complicated process in which, in addition to the standard pharmacological action, it is necessary to append a comprehensive approach. Introducing the aspect of non-pharmacological treatment of diabetes allows one to alleviate its many adverse complications. Therefore, it seems important to look for substances that, when included in the daily diet, can improve diabetic parameters. Magnolol, a polyphenolic compound found in magnolia bark, is known for its health-promoting activities and multidirectional beneficial effects on the body. Accordingly, the goal of this review is to systematize the available scientific literature on its beneficial effects on type 2 diabetes and its complications. Taking the above into consideration, the article collects data on the favorable effects of magnolol on parameters related to glycemia, lipid metabolism, or oxidative stress in the course of diabetes. After careful analysis of many scientific articles, it can be concluded that this lignan is a promising agent supporting the conventional therapies with antidiabetic drugs in order to manage diabetes and diabetes-related diseases.
C1 [Szalabska-Rapala, Katarzyna] Med Univ Silesia, Fac Pharmaceut Sci Sosnowiec, Dept Pharmacognosy & Phytochem, Doctoral Sch,Discipline Pharmaceut Sci, Jagiellonska 4, PL-41200 Sosnowiec, Poland.
   [Borymska, Weronika; Kaczmarczyk-Sedlak, Ilona] Med Univ Silesia, Fac Pharmaceut Sci Sosnowiec, Dept Pharmacognosy & Phytochem, Jagiellonska 4, PL-41200 Sosnowiec, Poland.
C3 Medical University of Silesia; Medical University of Silesia
RP Szalabska-Rapala, K (corresponding author), Med Univ Silesia, Fac Pharmaceut Sci Sosnowiec, Dept Pharmacognosy & Phytochem, Doctoral Sch,Discipline Pharmaceut Sci, Jagiellonska 4, PL-41200 Sosnowiec, Poland.
EM d200886@365.sum.edu.pl; wwojnar@sum.edu.pl; isedlak@sum.edu.pl
RI Borymska, Weronika/K-4803-2019
OI Kaczmarczyk-Zebrowska, Ilona/0000-0002-3137-1694; Szalabska-Rapala,
   Katarzyna/0000-0001-5240-7396; Borymska, Weronika/0000-0002-3013-7564
FU Medical University of Silesia in Katowice, Poland
FX The APC was covered by Medical University of Silesia in Katowice,
   Poland.
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NR 149
TC 27
Z9 27
U1 2
U2 26
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD SEP
PY 2021
VL 22
IS 18
AR 10050
DI 10.3390/ijms221810050
PG 23
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA UV7NC
UT WOS:000699659100001
PM 34576213
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Si, LYN
   Ali, SAM
   Latip, J
   Fauzi, NM
   Budin, SB
   Zainalabidin, S
AF Si, Lislivia Yiang-Nee
   Ali, Siti Aishah Mohd
   Latip, Jalifah
   Fauzi, Norsyahida Mohd
   Budin, Siti Balkis
   Zainalabidin, Satirah
TI Roselle is cardioprotective in diet-induced obesity rat model with
   myocardial infarction
SO LIFE SCIENCES
LA English
DT Article
DE Obesity; Oxidative stress; Myocardial infarction; Roselle; Cardiac
   function
ID SPONTANEOUSLY HYPERTENSIVE-RATS; LOW-DENSITY-LIPOPROTEIN;
   HIBISCUS-SABDARIFFA L.; OXIDATIVE STRESS; CARDIAC FIBROSIS;
   NATRIURETIC-PEPTIDE; METABOLIC SYNDROME; CONVERTING ENZYME; AQUEOUS
   EXTRACTS; ANGIOTENSIN-II
AB Aims: Obesity increase the risks of hypertension and myocardial infarction (MI) mediated by oxidative stress. This study was undertaken to investigate the actions of roselle aqueous extract (R) on cardiotoxicity in obese (OB) rats and thereon OB rats subjected to MI.
   Main methods: Male Sprague-Dawley rats were fed with either normal diet or high-fat diet for 8 weeks. Firstly, OB rats were divided into (1) OB and (2) OB + R (100 mg/kg, p.o, 28 days). Then, OB rats were subjected to MI (ISO, 85 mg/kg, s.c, 2 days) and divided into three groups: (1) OB + MI, (2) OB + MI + R and (3) OB + MI + enalapril for another 4 weeks.
   Key findings: Roselle ameliorated OB and OB + MI's cardiac systolic dysfunction and reduced cardiac hypertrophy and fibrosis. The increased oxidative markers and decreased antioxidant enzymes in OB and OB + MI groups were all attenuated by roselle.
   Significance: These observations indicate the protective effect of roselle on cardiac dysfunction in OB and OB + MI rats, which suggest its potential to be developed as a nutraceutical product for obese and obese patients with MI in the future.
C1 [Si, Lislivia Yiang-Nee; Budin, Siti Balkis; Zainalabidin, Satirah] Univ Kebangsaan Malaysia, Fac Hlth Sci, Sch Diagnost & Appl Hlth Sci, Program Biomed Sci, Jalan Raja Muda Abdul Aziz, Kuala Lumpur 50300, Malaysia.
   [Ali, Siti Aishah Mohd; Latip, Jalifah] Univ Kebangsaan Malaysia, Fac Sci & Technol, Sch Chem Sci & Food Technol, Bangi 43600, Selangor, Malaysia.
   [Fauzi, Norsyahida Mohd] Univ Kebangsaan Malaysia, Fac Pharm, Drug & Herbal Res Ctr, Jalan Raja Muda Abdul Aziz, Kuala Lumpur 50300, Malaysia.
C3 Universiti Kebangsaan Malaysia; Universiti Kebangsaan Malaysia;
   Universiti Kebangsaan Malaysia
RP Zainalabidin, S (corresponding author), Univ Kebangsaan Malaysia, Fac Hlth Sci, Sch Diagnost & Appl Hlth Sci, Program Biomed Sci, Jalan Raja Muda Abdul Aziz, Kuala Lumpur 50300, Malaysia.
EM satirah@ukm.edu.my
RI Zainalabidin, Satirah/AAH-6677-2019; Budin, Siti Balkis/ABB-8820-2021
OI -, SITI AISHAH BINTI MOHD ALI/0000-0002-1421-7089
FU NKEA Research Grant Scheme (NRGS) from Ministry of Agriculture (MOA),
   Malaysia [NH1014D061]
FX This study was supported by NKEA Research Grant Scheme (NRGS) from
   Ministry of Agriculture (MOA) (NH1014D061), Malaysia. We are thankful to
   Faculty of Pharmacy, UKM for lending their Langendorff apparatus,
   bachelor student Miss Rumaisak Farizal for her assistance in animal
   handling and postgraduate student Mr Anand Ramalingam for technical
   assistance in PCR.
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NR 58
TC 27
Z9 28
U1 2
U2 22
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0024-3205
EI 1879-0631
J9 LIFE SCI
JI Life Sci.
PD DEC 15
PY 2017
VL 191
BP 157
EP 165
DI 10.1016/j.lfs.2017.10.030
PG 9
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA FL6SM
UT WOS:000414376500021
PM 29066253
DA 2025-06-11
ER

PT J
AU Paternain, L
   Martisova, E
   Milagro, FI
   Ramírez, MJ
   Martínez, JA
   Campión, J
AF Paternain, Laura
   Martisova, Eva
   Milagro, Fermin I.
   Ramirez, Maria J.
   Alfredo Martinez, J.
   Campion, Javier
TI Postnatal maternal separation modifies the response to an obesogenic
   diet in adulthood in rats
SO DISEASE MODELS & MECHANISMS
LA English
DT Article
ID MONOCYTE CHEMOATTRACTANT PROTEIN-1; SPRAGUE-DAWLEY RATS; CHRONIC-MILD
   STRESS; EARLY-LIFE STRESS; HIGH-FAT DIET; METABOLIC SYNDROME;
   SEX-DIFFERENCES; FEMALE RATS; MESSENGER-RNA; BODY-WEIGHT
AB An early-life adverse environment has been implicated in the susceptibility to different diseases in adulthood, such as mental disorders, diabetes and obesity. We analyzed the effects of a high-fat sucrose (HFS) diet for 35 days in adult female rats that had experienced 180 minutes daily of maternal separation (MS) during lactancy. Changes in the obesity phenotype, biochemical profile, levels of glucocorticoid metabolism biomarkers, and the expression of different obesity-and glucocorticoid-metabolism-related genes were analyzed in periovaric adipose tissue. HFS intake increased body weight, adiposity and serum leptin levels, whereas MS decreased fat pad masses but only in rats fed an HFS diet. MS reduced insulin resistance markers but only in chow-fed rats. Corticosterone and estradiol serum levels did not change in this experimental model. A multiple gene expression analysis revealed that the expression of adiponutrin (Adpn) was increased owing to MS, and an interaction between HFS diet intake and MS was observed in the mRNA levels of leptin (Lep) and peroxisome proliferator-activated receptor gamma coactivator 1 alpha (Ppargc1a). These results revealed that early-life stress affects the response to an HFS diet later in life, and that this response can lead to phenotype and transcriptomic changes.
C1 [Paternain, Laura; Milagro, Fermin I.; Alfredo Martinez, J.; Campion, Javier] Univ Navarra, Dept Nutr & Food Sci, Pamplona 31008, Spain.
   [Martisova, Eva; Ramirez, Maria J.] Univ Navarra, Dept Pharmacol, Pamplona 31008, Spain.
C3 University of Navarra; University of Navarra
RP Campión, J (corresponding author), Univ Navarra, Dept Nutr & Food Sci, C Irunlarrea 1, Pamplona 31008, Spain.
EM jcampion@unav.es
RI Milagro, Fermin/F-2315-2015; Paternain, Laura/AAB-3917-2020; Ramirez,
   Maria Javier/H-4383-2017; Martinez Hernandez, J Alfredo/K-8709-2014
OI Milagro, Fermin I./0000-0002-3228-9916; Paternain,
   Laura/0000-0002-1119-5232; Campion, Javier/0000-0002-6522-8271; Ramirez,
   Maria Javier/0000-0002-3488-9579; Martinez Hernandez, J
   Alfredo/0000-0001-5218-6941
FU Linea Especial from the University of Navarra [LE/97]; CAN (Caja de
   Ahorros de Navarra); Carlos III Health Institute (CIBERobn/RETICS
   project, Spain) [CB06/03/1017]; "Asociacion de Amigos de la Universidad
   de Navarra"; IBERCAJA (Spain)
FX Funding for this study was provided by Linea Especial (LE/97) from the
   University of Navarra, CAN (Caja de Ahorros de Navarra) and the Carlos
   III Health Institute (CIBERobn/RETICS project, Spain; grant
   CB06/03/1017). The authors wish to thank the "Asociacion de Amigos de la
   Universidad de Navarra" and IBERCAJA (Spain) for the doctoral grant of
   L.P.
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NR 76
TC 36
Z9 38
U1 0
U2 17
PU COMPANY OF BIOLOGISTS LTD
PI CAMBRIDGE
PA BIDDER BUILDING CAMBRIDGE COMMERCIAL PARK COWLEY RD, CAMBRIDGE CB4 4DL,
   CAMBS, ENGLAND
SN 1754-8403
EI 1754-8411
J9 DIS MODEL MECH
JI Dis. Model. Mech.
PD SEP
PY 2012
VL 5
IS 5
BP 691
EP 697
DI 10.1242/dmm.009043
PG 7
WC Cell Biology; Medicine, Research & Experimental; Pathology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Research & Experimental Medicine; Pathology
GA 005GB
UT WOS:000308737400019
PM 22773756
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Sato, T
   Takeda, H
   Otake, S
   Yokozawa, J
   Nishise, S
   Fujishima, S
   Orii, T
   Fukui, T
   Takano, J
   Sasaki, Y
   Nagino, K
   Iwano, D
   Yaoita, T
   Kawata, S
AF Sato, Takeshi
   Takeda, Hiroaki
   Otake, Sayaka
   Yokozawa, Junji
   Nishise, Shoichi
   Fujishima, Shoichiro
   Orii, Tomohiko
   Fukui, Tadahisa
   Takano, Jun
   Sasaki, Yu
   Nagino, Ko
   Iwano, Daisuke
   Yaoita, Takao
   Kawata, Sumio
TI Increased Plasma Levels of 8-Hydroxydeoxyguanosine Are Associated with
   Development of Colorectal Tumors
SO JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION
LA English
DT Article
DE oxidative stress; tumorigenesis; reactive oxygen species; colonoscopy;
   early cancer
ID OXIDATIVE STRESS; METABOLIC SYNDROME; DNA-DAMAGE; CANCER; CARCINOMA;
   8-OHDG; MECHANISM; MARKER; HOGG1; BASE
AB Increased oxidative stress is generally thought to be associated with tumorigenesis. In this cross-sectional study, we evaluated plasma 8-hydroxydeoxyguanosine (8-OHdG) levels in patients with colorectal adenoma and cancer, as a surrogate marker of oxidative damage to deoxyribonucleic acid (DNA). We collected blood samples from 58 patients with adenoma, 32 with early cancer, 25 with advanced cancer, and 36 without polyps or cancer (as controls), and measured plasma levels of 8-OHdG by enzyme-linked immunosorbent assay. Univariate analysis by logistic regression showed that an increased level of 8-OHdG was a significant risk for adenoma [odds ratio (OR) 1.393, 95% confidence interval (CI) 1.008-1.926, p = 0.045]. In patients with early cancer, univariate analysis revealed significant differences for age, body mass index (BMI), systolic blood pressure, and 8-OHdG level. Subsequent multivariate analysis revealed that 8-OHdG [OR 1.627, 95% CI 1.079-2.453, p = 0.020] and BMI [OR 1.283, 95% CI 1.038-1.585, p = 0.021] were significant risk factors for early cancer. However, 8-OHdG was not a significant risk factor for advanced cancer. Our results suggest that an increased plasma level of 8-OHdG is associated with development of colorectal adenoma and cancer.
C1 [Takeda, Hiroaki] Yamagata Univ Hosp, Div Endoscopy, Yamagata 9909585, Japan.
   [Sato, Takeshi; Otake, Sayaka; Yokozawa, Junji; Nishise, Shoichi; Fujishima, Shoichiro; Orii, Tomohiko; Fukui, Tadahisa; Takano, Jun; Sasaki, Yu; Nagino, Ko; Iwano, Daisuke; Yaoita, Takao; Kawata, Sumio] Yamagata Univ, Fac Med, Dept Gastroenterol, Yamagata 9909585, Japan.
C3 Yamagata University; Yamagata University
RP Takeda, H (corresponding author), Yamagata Univ Hosp, Div Endoscopy, 2-2-2 Iida Nishi, Yamagata 9909585, Japan.
EM htakeda@med.id.yamagata-u.ac.jp
RI Sasaki, Yu/AAT-5102-2020
OI Sasaki, Yu/0000-0002-3939-9480
CR Cangemi R, 2007, FREE RADICAL BIO MED, V43, P853, DOI 10.1016/j.freeradbiomed.2007.06.002
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NR 18
TC 43
Z9 45
U1 0
U2 16
PU JOURNAL CLINICAL BIOCHEMISTRY & NUTRITION
PI KYOTO
PA KYOTO PREFECTURAL UNIV MED, GRAD SCH MEDICAL SCIENCE, DEPT MOLECULAR
   GASTROENTEROLOGY & HEPATOLOGY, KYOTO, 602-8566, JAPAN
SN 0912-0009
EI 1880-5086
J9 J CLIN BIOCHEM NUTR
JI J. Clin. Biochem. Nutr.
PD JUL
PY 2010
VL 47
IS 1
BP 59
EP 63
DI 10.3164/jcbn.10-12
PG 5
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 650XY
UT WOS:000281888900009
PM 20664732
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Cizza, G
   Nguyen, VT
   Eskandari, F
   Duan, ZG
   Wright, EC
   Reynolds, JC
   Ahima, RS
   Blackman, MR
AF Cizza, Giovanni
   Nguyen, Vi T.
   Eskandari, Farideh
   Duan, Zhigang
   Wright, Elizabeth C.
   Reynolds, James C.
   Ahima, Rexford S.
   Blackman, Marc R.
CA POWER Study Grp
TI Low 24-Hour Adiponectin and High Nocturnal Leptin Concentrations in a
   Case-Control Study of Community-Dwelling Premenopausal Women With Major
   Depressive Disorder: The Premenopausal, Osteopenia/Osteoporosis, Women,
   Alendronate, Depression (POWER) Study
SO JOURNAL OF CLINICAL PSYCHIATRY
LA English
DT Article
ID PLASMA ADIPONECTIN; MARKERS; RISK; ASSOCIATION; PULSATILITY; PREVALENCE;
   ADIPOKINES; BIOMARKERS; DYNAMICS; FEEDBACK
AB Objective: Major depressive disorder (MDD) is associated with immune system dysfunction and disruption of multiple circadian systems. Adiponectin is an adipo-cytokine with anti-inflammatory and antiatherogenic effects: Circulating concentrations are inversely related to adiposity and risks of metabolic syndrome and diabetes mellitus. Our goals were (1) to establish whether premenopausal women with MDD exhibit decreased plasma adiponectin concentrations and/or disruption of circadian adiponectin rhythmicity; (2) to assess whether there is a relationship between adiponectin and MDD; and (3) to explore the temporal relationships among adiponectin, leptin, corticotropin, and cortisol secretion.
   Method: We conducted a case-control study of community-dwelling premenopausal women with DSM-IV MDD (n=23) and age- and body mass index (BMI)-matched control subjects (n=23). Main outcome measures were circulating concentrations of adiponectin, leptin, corticotropin, and cortisol measured hourly for 24 hours. Subjects were recruited from July 1, 2001, to February 28, 2003.
   Results: Women with MDD had approximately 30% lower mean 24-hour concentration of adiponectin than did control subjects. Adiponectin concentration was inversely related to depression severity and total duration of disease, suggesting a causal link. In contrast, mean nocturnal leptin concentration was higher in the MDD versus control groups. Mean leptin concentration was inversely related to cortisol and adiponectin concentrations, both in subjects with depression and in control subjects. In cross-correlation analyses, the relationship between corticotropin and cortisol concentrations was stronger in women with MDD than in control subjects, a finding consistent with hypothalamic-pituitary-adrenal (HPA) axis activation in MDD.
   Conclusions: In premenopausal women with MDD, reduced daily adiponectin production may increase the risk of diabetes mellitus, and elevated leptin may contribute to osteoporosis. J Clin Psychiatry 2010;71(8):1079-1087 (C) Copyright 2010 Physicians Postgraduate Press, Inc.
C1 [Cizza, Giovanni] NIDDK, Clin Endocrine Sect, Clin Endocrinol Branch, NIH,CRC, Bethesda, MD 20892 USA.
   [Nguyen, Vi T.] Massachusetts Gen Hosp, Pediat Endocrine Unit, Boston, MA 02114 USA.
   [Eskandari, Farideh] NIMH, Sect Neuroendocrine Immunol & Behav, Integrat Neural Immune Program, Intramural Res Program,NIH, Bethesda, MD 20892 USA.
   [Duan, Zhigang; Wright, Elizabeth C.] NIDDK, Off Director, Bethesda, MD 20892 USA.
   [Reynolds, James C.] NIH, Dept Radiol, Warren G Magnuson Clin Ctr, Bethesda, MD 20892 USA.
   [Ahima, Rexford S.] Univ Penn, Sch Med, Dept Med, Div Endocrinol Diabet & Metab, Philadelphia, PA 19104 USA.
   [Blackman, Marc R.] NIH, Endocrine Sect, NCCAM, Bethesda, MD 20892 USA.
   [Blackman, Marc R.] Vet Affairs Med Ctr, Res Serv, Washington, DC 20422 USA.
C3 National Institutes of Health (NIH) - USA; NIH National Institute of
   Diabetes & Digestive & Kidney Diseases (NIDDK); Harvard University;
   Harvard University Medical Affiliates; Massachusetts General Hospital;
   National Institutes of Health (NIH) - USA; NIH National Institute of
   Mental Health (NIMH); National Institutes of Health (NIH) - USA; NIH
   National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK);
   NIH Office of the Director; National Institutes of Health (NIH) - USA;
   University of Pennsylvania; National Institutes of Health (NIH) - USA;
   NIH National Center for Complementary & Alternative Medicine (NCCAM); US
   Department of Veterans Affairs; Veterans Health Administration (VHA)
RP Cizza, G (corresponding author), NIDDK, Clin Endocrine Sect, Clin Endocrinol Branch, NIH,CRC, Bldg 10,Rm 6-3940, Bethesda, MD 20892 USA.
EM cizzag@intra.niddk.nih.gov
RI Ahima, Rexford/W-1394-2019; Blackman, Marc/AAT-5771-2021; Wright-Jin,
   Elizabeth/N-1111-2019
FU NIMH; NIDDK; NCCAM, NIH, Bethesda, Maryland
FX The study was fully supported by the Intramural Research Programs of the
   NIMH; NIDDK; and NCCAM, NIH, Bethesda, Maryland.
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NR 45
TC 61
Z9 70
U1 0
U2 11
PU PHYSICIANS POSTGRADUATE PRESS
PI MEMPHIS
PA P O BOX 752870, MEMPHIS, TN 38175-2870 USA
SN 0160-6689
EI 1555-2101
J9 J CLIN PSYCHIAT
JI J. Clin. Psychiatry
PD AUG
PY 2010
VL 71
IS 8
BP 1079
EP 1087
DI 10.4088/JCP.09m05314blu
PG 9
WC Psychology, Clinical; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA 643KY
UT WOS:000281296500016
PM 20492842
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Fittipaldi, EOD
   de Andrade, AD
   Santos, ACO
   Campos, S
   Fernandes, J
   Catanho, MTJD
AF da Silva Fittipaldi, Etiene Oliveira
   de Andrade, Armele Dornelas
   Oliveira Santos, Ana Celia
   Campos, Shirley
   Fernandes, Juliana
   Jansen de Almeida Catanho, Maria Teresa
TI Depressive Symptoms are Associated with High Levels of Serum Low-Density
   Lipoprotein Cholesterol in Older Adults with Type 2 Diabetes Mellitus
SO ARQUIVOS BRASILEIROS DE CARDIOLOGIA
LA English
DT Article
DE Cardiovascular Diseases; Diabetes Mellitus; Hypertension; Dyslipidemias;
   Depression; Depressive Disorder; Lipoproteins; LDL
ID CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; PREVALENCE; PEOPLE;
   ABNORMALITIES; DYSLIPIDEMIA; MANAGEMENT; RISK; SEX
AB Background: Type 2 Diabetes Mellitus (T2DM) is common in older adults, who also present a high level of risk factors for cardiovascular disease (CVD), such as dyslipidemia. However, the role of depression in T2DM patients and its relationship with CVD risk factors are understudied.
   Objective: The present study aimed to investigate the relationship between depressive symptoms (DS) and known cardiovascular risk factors in community dwelling older adults with T2DM.
   Methods: This is a cross sectional study, in which 85 community-dwelling older adults with T2DM were assessed. DS was assessed using the Yesavage Geriatric Depression Scale - short version (GDS-15). The following cardiovascular risk factors were evaluated: systolic (SBP) and diastolic blood pressure (DBP), fasting plasma glucose (FPG), lipid profile (serum triglycerides - TG, serum total cholesterol - TC, serum low-density lipoprotein cholesterol - LDL-C, and serum high-density lipoprotein cholesterol - HDL-C) and body mass index (BMI). Poisson multiple regression was performed to test the association between DS and each cardiovascular risk factor adjusted by sex, age, time spent in moderate physical activity, and functional status. The significance level adopted for the analysis was 5%.
   Results: Among all the analyzed risk factors, only high levels of LDL-C were related to high DS (PR=1.005, CI 95% 1.002-1.008). A significant association was observed between HDL-C levels (PR=0.99, CI 95% 0.98-0.99) and SBP (PR=1.009, CI 95% 1.004-1.014).
   Conclusion: In older adults with T2DM, the presence of DS was associated with LDL-C, HDL-C levels and SBP, even after adjusting for sex, age, physical activity level and functional capacity.
C1 [da Silva Fittipaldi, Etiene Oliveira; de Andrade, Armele Dornelas; Campos, Shirley; Fernandes, Juliana; Jansen de Almeida Catanho, Maria Teresa] Univ Fed Pernambuco, Recife, PE, Brazil.
   [Oliveira Santos, Ana Celia] Univ Pernambuco, Recife, PE, Brazil.
C3 Universidade Federal de Pernambuco; Universidade de Pernambuco (UPE)
RP Fittipaldi, EOD (corresponding author), Univ Fed Pernambuco, Dept Fisioterapia, Av Jorn Anibal Fernandes 173, BR-50740560 Recife, PE, Brazil.
EM etienefittipaldi@yahoo.com.br
RI Fernandes, Juliana/AAT-8850-2020; Dornelas de Andrade,
   Armele/AAO-7337-2021; Campos, Shirley/AAR-6026-2021; Campos,
   Shirley/P-6701-2018
OI Dornelas de Andrade, Armele/0000-0001-9430-4395; Campos,
   Shirley/0000-0003-3079-8300; Fernandes, Juliana/0000-0002-7509-8853;
   Fittipaldi, Etiene/0000-0002-1524-6930
FU Fundacao de Amparo a Ciencia e Tecnologia de Pernambuco [APQ
   0234-4/.08/13]; CNPq [48206/2012-0]
FX This study was funded by Fundacao de Amparo a Ciencia e Tecnologia de
   Pernambuco (APQ 0234-4/.08/13); Edital Universal CNPq 48206/2012-0.
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NR 34
TC 5
Z9 7
U1 0
U2 2
PU ARQUIVOS BRASILEIROS CARDIOLOGIA
PI RIO DE JANEIRO
PA AVENIDA MARECHAL CAMARA 160-330 CENTRO, RIO DE JANEIRO, RJ 20 020-907,
   BRAZIL
SN 0066-782X
J9 ARQ BRAS CARDIOL
JI Arq. Bras. Cardiol.
PD SEP
PY 2020
VL 115
IS 3
BP 462
EP 467
DI 10.36660/abc.20190404
PG 6
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA NZ6FU
UT WOS:000577202500007
PM 32696856
OA Green Published
DA 2025-06-11
ER

PT J
AU Ferrari, U
   Banning, F
   Freibothe, I
   Tröndle, K
   Sacco, V
   Wichmann, C
   Reif, S
   Moschko, S
   Potzel, A
   Gar, C
   Sommer, NN
   Popp, D
   Seissler, J
   Lechner, A
   Künzel, H
AF Ferrari, U.
   Banning, F.
   Freibothe, I.
   Troendle, K.
   Sacco, V.
   Wichmann, C.
   Reif, S.
   Moschko, S.
   Potzel, A.
   Gar, C.
   Sommer, N. N.
   Popp, D.
   Seissler, J.
   Lechner, A.
   Kuenzel, H.
TI Depressive symptoms, impaired glucose metabolism, high visceral fat, and
   high systolic blood pressure in a subgroup of women with recent
   gestational diabetes
SO JOURNAL OF PSYCHIATRIC RESEARCH
LA English
DT Article
DE Depressive symptoms; Prediabetes; Gestational diabetes; Glucose
   tolerance; Metabolic syndrome; Visceral fat; Biomarkers
ID ANTIDEPRESSANT MEDICATION; MAJOR DEPRESSION; GLYCEMIC CONTROL; SLEEP
   QUALITY; RISK-FACTOR; METAANALYSIS; DISORDER; GERMANY; PREVALENCE;
   TOLERANCE
AB Women with gestational diabetes (GDM) are a high risk group for early type 2 diabetes (T2D). Depression is a risk factor for T2D in the general population. We investigated in women after a recent pregnancy with GDM and without a clinical diagnosis of depression, whether mild to moderate depressive symptoms associate with pathologic glucose metabolism. In a cross-sectional analysis, we examined 173 women, 9 3 months after delivery with several psychopathological assessments, 5-point oral glucose tolerance test with insulin, anthropometrics, and laboratory chemistry. In a subgroup of 101 women, abdominal visceral fat was quantified by magnetic resonance imaging (MRI).
   A total of 22 women (13%) showed mild to moderate depressive symptoms, and the proportion of women with pathologic glucose metabolism (impaired fasting glucose, impaired glucose tolerance, or T2D) was higher in this group than in the women without depressive symptoms (59.1% vs. 33.1%, p = 0.018). Women with depressive symptoms also had higher body mass index (BMI), systolic blood pressure, plasma leptin, plasma resistin, and abdominal visceral fat volume. Pathologic glucose metabolism (OR = 2.594, 95% CI: 1.021-6.592), systolic blood pressure (OR = 1.076, 95% CI: 1.027-1.128), and abdominal visceral fat volume (OR = 2.491, 95% CI: 1.142-5.433) remained, even after adjustment for BMI, associated with the presence of depressive symptoms.
   Taken together, we found depressive symptoms at a level not generally diagnosed in clinical practice in a subgroup of women with recent GDM. This subgroup also showed an unfavorable metabolic profile. Mild to moderate depressive symptoms may therefore help to identify this special subgroup.
C1 [Ferrari, U.; Banning, F.; Freibothe, I.; Troendle, K.; Sacco, V.; Wichmann, C.; Reif, S.; Moschko, S.; Potzel, A.; Gar, C.; Seissler, J.; Lechner, A.] Klinikum Univ Munchen, Med Klin & Poliklin 4, Campus Innenstack, Munich, Germany.
   [Ferrari, U.; Banning, F.; Freibothe, I.; Troendle, K.; Sacco, V.; Wichmann, C.; Reif, S.; Moschko, S.; Potzel, A.; Gar, C.; Seissler, J.; Lechner, A.] Helmholtz Zentrum Munchen, CCG Type 2 Diabet, Munich, Germany.
   [Ferrari, U.; Banning, F.; Freibothe, I.; Troendle, K.; Sacco, V.; Wichmann, C.; Reif, S.; Moschko, S.; Potzel, A.; Gar, C.; Seissler, J.; Lechner, A.] DZD, Munich, Germany.
   [Sommer, N. N.; Popp, D.] Klinikum Univ Munchen, Inst Clin Radiol, Munich, Germany.
   [Kuenzel, H.] Klinikum Univ Munchen, Med Klin & Poliklin 4, Dept Psychosomat Med, Munich, Germany.
C3 University of Munich; Helmholtz Association; Helmholtz-Center Munich -
   German Research Center for Environmental Health; German Center for
   Diabetes Research (DZD); University of Munich; University of Munich
RP Künzel, H (corresponding author), Klinikum Univ Munchen, Med Klin & Poliklin 4, Campus Innenstack, Munich, Germany.
EM Heike.Kuenzel@med.uni-muenchen.de
RI Gar, Christina/I-6815-2019; Popp, Daniel/E-6112-2019
OI Gar, Christina/0000-0002-4218-6945
FU Helmholtz Zentrum Munchen; Deutsches Zentrum fur Diabetesforschung;
   Klinikum der Universitat Munchen [German Center for Diabetes Research];
   Klinikum der Universitat Munchen [Klinikum der Universitat Munchen in
   Munich, Germany
FX This work was funded by the Helmholtz Zentrum Munchen, Deutsches Zentrum
   fur Diabetesforschung, and Klinikum der Universitat Munchen [German
   Center for Diabetes Research and the Klinikum der Universitat Munchen in
   Munich, Germany].
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NR 33
TC 9
Z9 9
U1 0
U2 21
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-3956
EI 1879-1379
J9 J PSYCHIATR RES
JI J. Psychiatr. Res.
PD FEB
PY 2018
VL 97
BP 89
EP 93
DI 10.1016/j.jpsychires.2017.12.001
PG 5
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA FU1YY
UT WOS:000423646600014
PM 29223020
DA 2025-06-11
ER

PT J
AU Fujii, S
   Sawa, T
   Nishida, M
   Ihara, H
   Ida, T
   Motohashi, H
   Akaike, T
AF Fujii, Shigemoto
   Sawa, Tomohiro
   Nishida, Motohiro
   Ihara, Hideshi
   Ida, Tomoaki
   Motohashi, Hozumi
   Akaike, Takaaki
TI Redox signaling regulated by an electrophilic cyclic nucleotide and
   reactive cysteine persulfides
SO ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
LA English
DT Article
DE Electrophilic signaling; 8-Nitro-cGMP; NO; Redox signaling
ID NITRIC-OXIDE; OXIDATIVE STRESS; S-NITROSYLATION; NADPH OXIDASES;
   PROTEIN; GLUTATHIONE; MECHANISMS; CHEMISTRY; DEFINES; BIOLOGY
AB Reactive oxygen (oxidant) and free radical species are known to cause nonspecific damage of various biological molecules. The oxidant toxicology is developing an emerging concept of the physiological functions of reactive oxygen species in cell signaling regulation. Redox signaling is precisely modulated by endogenous electrophilic substances that are generated from reactive oxygen species during cellular oxidative stress responses. Among diverse electrophilic molecular species that are endogenously generated, 8-nitroguanosine 3',5'-cyclic monophosphate (8-nitro-cGMP) is a unique second messenger whose formation, signaling, and metabolism in cells was recently clarified. Most important, our current studies revealed that reactive cysteine persulfides that are formed abundantly in cells are critically involved in the metabolism of 8-nitro-cGMP. Modern redox biology involves frontiers of cell research and stem cell research; medical and clinical investigations of infections, cancer, metabolic syndrome, aging, and neurodegenerative diseases; and other fields. 8-Nitro-cGMP-mediated signaling and metabolism in cells may therefore be potential targets for drug development, which may lead to discovery of new therapeutic agents for many diseases. (C) 2015 Elsevier Inc. All rights reserved.
C1 [Fujii, Shigemoto; Ida, Tomoaki; Akaike, Takaaki] Tohoku Univ, Grad Sch Med, Dept Environm Hlth Sci & Mol Toxicol, Sendai, Miyagi 9808575, Japan.
   [Sawa, Tomohiro] Kumamoto Univ, Grad Sch Med Sci, Dept Microbiol, Kumamoto 8608556, Japan.
   [Nishida, Motohiro] Natl Inst Nat Sci, Natl Inst Physiol Sci, Div Cardiocirculatory Signaling, Okazaki Inst Integrat Biosci, Okazaki, Aichi 4448787, Japan.
   [Nishida, Motohiro] Kyushu Univ, Grad Sch Pharmaceut Sci, Dept Translat Pharmaceut Sci, Fukuoka 8128582, Japan.
   [Nishida, Motohiro] Japan Sci & Technol Agcy JST, PRESTO, Kawaguchi, Saitama 3320012, Japan.
   [Ihara, Hideshi] Osaka Prefecture Univ, Grad Sch Sci, Dept Biol Sci, Osaka 5998531, Japan.
   [Motohashi, Hozumi] Tohoku Univ, Inst Dev Aging & Canc, Dept Gene Express Regulat, Sendai, Miyagi 9808575, Japan.
C3 Tohoku University; Kumamoto University; National Institutes of Natural
   Sciences (NINS) - Japan; National Institute for Physiological Sciences
   (NIPS); Okazaki Institute for Integrative Bioscience (OIIB); Kyushu
   University; Japan Science & Technology Agency (JST); Osaka Metropolitan
   University; Tohoku University
RP Akaike, T (corresponding author), Tohoku Univ, Grad Sch Med, Dept Environm Hlth Sci & Mol Toxicol, Sendai, Miyagi 9808575, Japan.
EM takaike@med.tohoku.ac.jp
RI Motohashi, Hozumi/AAZ-2628-2020
OI Ida, Tomoaki/0000-0002-4443-6127; Motohashi, Hozumi/0000-0002-7261-1033;
   Nishida, Motohiro/0000-0002-2587-5458
FU Ministry of Education, Culture, Sports, Science and Technology (MEXT),
   Japan (MEXT KAKENHI) [20117001]; MEXT KENHI [15K08456, 26670131,
   25293018, 25430069, 15K20876, 15H04692, 25253020]; MEXT [26111008];
   Grants-in-Aid for Scientific Research [15H04692, 20117001, 16K15228,
   15K20876] Funding Source: KAKEN
FX We thank J.B. Gandy for her excellent editing of the manuscript. We
   gratefully thank M. Yamamoto, K. Uchida, Y. Kumagai, and other members
   of the 12 groups of the program project entitled "Signaling Functions of
   Reactive Oxygen Species," which was supported by Grants-in-Aid for
   Scientific Research on Innovative Areas (Research in a Proposed Research
   Area) from the Ministry of Education, Culture, Sports, Science and
   Technology (MEXT), Japan, from 2008 to 2012 (MEXT KAKENHI Grant Number
   20117001), for their invaluable discussion and collaboration. This work
   was supported in part by MEXT KENHI Grant Number 15K08456 (to S.F.),
   26670131 (to T.S.), 25293018 (to M.N), 25430069 (H.I.), 15K20876 (to
   T.I.), 15H04692 (to H.M.), 25253020 (to T.A.), and by Grants-in-Aid for
   Scientific Research and Grants-in-Aid for Scientific Research on
   Innovative Areas (Research in a Proposed Research Area), from MEXT
   (Grant Number 26111008 to T.A.).
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NR 49
TC 16
Z9 17
U1 0
U2 21
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0003-9861
EI 1096-0384
J9 ARCH BIOCHEM BIOPHYS
JI Arch. Biochem. Biophys.
PD APR 2
PY 2016
VL 595
SI SI
BP 140
EP 146
DI 10.1016/j.abb.2015.11.008
PG 7
WC Biochemistry & Molecular Biology; Biophysics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics
GA DK1WF
UT WOS:000374705000028
PM 27095231
DA 2025-06-11
ER

PT J
AU van Empel, V
   Brunner-La Rocca, HP
AF van Empel, Vanessa
   Brunner-La Rocca, Hans-Peter
TI Inflammation in HFpEF: Key or circumstantial?
SO INTERNATIONAL JOURNAL OF CARDIOLOGY
LA English
DT Review
DE Heart failure; Heart failure with preserved ejection fraction; Heart
   failure with reduced ejection fraction; Inflammation; Endothelial
   dysfunction; Oxidative stress
ID PRESERVED EJECTION FRACTION; CHRONIC HEART-FAILURE; C-REACTIVE PROTEIN;
   DIASTOLIC DYSFUNCTION; HYPERTENSIVE-RATS; EXERCISE CAPACITY; MYOCARDIAL
   FIBROSIS; CARDIAC-HYPERTROPHY; METABOLIC SYNDROME; BODY-COMPOSITION
AB Heart failure (HF) can be split into HF with reduced ejection fraction (HFrEF) and HF with preserved ejection fraction (HFpEF). Currently the pathophysiologic mechanisms involved in HFpEF remain largely unknown. The neurohumoral and sympathetic nervous systems seem not to play a crucial role in HFpEF, as treatments targeting these pathways do not show beneficial effects in HFpEF patients, in contrast to HFrEF patients. A better understanding of the pathophysiological processes involved in HFpEF is needed, as there is no proven treatment for this disease at the moment. Recent data have yielded growing attention to the role of inflammation in HFpEF. In this review we discuss increased inflammation in HFpEF as demonstrated in translational animal models and human studies. This review evaluates whether inflammation plays a key role in HFpEF or is just a by-product of various comorbidities. Additionally, we analyze the involvement of oxidative stress and endothelial dysfunction and lastly we outline potential therapeutic targets. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
C1 [van Empel, Vanessa; Brunner-La Rocca, Hans-Peter] Maastricht Univ, Med Ctr, Dept Cardiol, Maastricht, Netherlands.
C3 Maastricht University
RP van Empel, V (corresponding author), Dept Cardiol, P Debyelaan 25, NL-6229 HX Maastricht, Netherlands.
EM Vanessa.Van.Empel@mumc.nl
RI Brunner-La Rocca, Hans-Peter/AAF-7330-2021; van EMPEL,
   Vanessa/JAN-7518-2023
OI Brunner-La Rocca, Hans-Peter/0000-0002-4356-8566
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NR 43
TC 50
Z9 52
U1 0
U2 10
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0167-5273
EI 1874-1754
J9 INT J CARDIOL
JI Int. J. Cardiol.
PD JUN 15
PY 2015
VL 189
BP 259
EP 263
DI 10.1016/j.ijcard.2015.04.110
PG 5
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA CI9RV
UT WOS:000355108300062
PM 25897922
DA 2025-06-11
ER

PT J
AU Alireza, S
   Leila, N
   Siamak, S
   Mohammad-Hasan, KA
   Behrouz, I
AF Alireza, Shirpoor
   Leila, Norouzi
   Siamak, Salami
   Mohammad-Hasan, Khadem Ansari
   Behrouz, Ilkhanizadeh
TI Effects of vitamin E on pathological changes induced by diabetes in rat
   lungs
SO RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
LA English
DT Article
DE Lung; Diabetes; Vitamin E; Rat
ID PROTEIN-KINASE-C; OXIDATIVE STRESS; ALPHA-TOCOPHEROL; NEUTROPHIL
   ELASTASE; METABOLIC-SYNDROME; FREE-RADICALS; IN-VITRO; HOMOCYSTEINE;
   INFLAMMATION; CELLS
AB Twenty-fourmale rats were divided into three groups: Control (C), non-treated diabetic (NTD), and vitamin E-treated diabetic (VETD) groups. After 6 weeks, we evaluated the changes in the alveolar epithelium, alveolar septum thickness, Hcy, and cathepsin G levels in the lung tissue and plasma serine protease inhibitor levels. The results revealed a significant increase in alveolar septum thickness, a high number of type II pneumocytes, high number of glycogen granules, increased vascular elastic membrane thickness, and increased Hcy and cathepsin G levels in the diabetic rats. Plasma level of serine protease inhibitors showed a significant decrease in the NTD animals. The vitamin E-treated rats showed significant amelioration of lung tissue changes, as well as restoration of high cathepsin G, Hcy levels, and serine protease inhibitors when compared to the control rats. These results suggest that diabetes induces lung tissue changes that may be stimulated by Hcy and cathepsin G mediated oxidative stress by, and protective effect could be achieved by using vitamin E. (C) 2012 Elsevier B.V. All rights reserved.
C1 [Alireza, Shirpoor; Leila, Norouzi] Urmia Med Univ, Fac Med, Dept Physiol, Orumiyeh, Iran.
   [Siamak, Salami] Shahid Beheshti Med Univ, Fac Med, Dept Clin Biochem, Tehran, Iran.
   [Mohammad-Hasan, Khadem Ansari] Urmia Med Univ, Fac Med, Dept Biochem, Orumiyeh, Iran.
   [Behrouz, Ilkhanizadeh] Urmia Med Univ, Fac Med, Dept Pathol, Orumiyeh, Iran.
C3 Shahid Beheshti University Medical Sciences
RP Alireza, S (corresponding author), Urmia Med Univ, Fac Med, Dept Physiol, Orumiyeh, Iran.
EM ashirpoor@yahoo.com; liliphysio@yahoo.com; salami.si@gmail.com;
   khademansari_mh@hotmail.com; ilkhanib@gmail.com
RI shirpoor, alireza/H-2793-2017; Salami, Siamak/G-5327-2011
OI Salami, Siamak/0000-0003-0393-5058
FU Office of the Vice Chancellor for Research and Technology, Urmia
   University of Medical Sciences
FX This research was funded by the Office of the Vice Chancellor for
   Research and Technology, Urmia University of Medical Sciences.
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NR 52
TC 9
Z9 9
U1 0
U2 4
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1569-9048
J9 RESP PHYSIOL NEUROBI
JI Respir. Physiol. Neuro.
PD FEB 1
PY 2013
VL 185
IS 3
BP 593
EP 599
DI 10.1016/j.resp.2012.11.017
PG 7
WC Physiology; Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology; Respiratory System
GA 095GO
UT WOS:000315322900014
PM 23247385
DA 2025-06-11
ER

PT J
AU Miraghajani, MS
   Esmaillzadeh, A
   Najafabadi, MM
   Mirlohi, M
   Azadbakht, L
AF Miraghajani, Maryam Sadat
   Esmaillzadeh, Ahmad
   Najafabadi, Mojgan Mortazavi
   Mirlohi, Maryam
   Azadbakht, Leila
TI Soy Milk Consumption, Inflammation, Coagulation, and Oxidative Stress
   Among Type 2 Diabetic Patients With Nephropathy
SO DIABETES CARE
LA English
DT Article
ID C-REACTIVE PROTEIN; POSTMENOPAUSAL WOMEN; METABOLIC SYNDROME;
   ISOFLAVONES; MARKERS; BIOAVAILABILITY; ASSOCIATION; COMPLICATIONS;
   BEVERAGES; ADULTS
AB OBJECTIVE-To determine the effects of soy milk consumption compared with cow's milk on inflammation, coagulation, and oxidative stress among patients with diabetic nephropathy.
   RESEARCH DESIGN AND METHODS-This randomized, crossover clinical trial was conducted on 25 type 2 diabetic patients with nephropathy. This study had two trial phases, each for 4 weeks and one washout period for 2 weeks. Patients were randomly assigned to consume a diet containing soy milk or a diet containing cow's milk.
   RESULTS-Soy milk consumption resulted in a significant reduction in D-dimer level (percent change: -3.77 vs. 16.13%; P < 0.05). This significant effect remained even after adjusting For confounding factor (carbohydrate intake). However, soy milk consumption had no significant effects on tumor necrosis factor-alpha, interleukin-6, high-sensitivity C-reactive protein (hs-CRP), and malondialdehyde levels. The result was near to significance regarding the effect of soy milk consumption on hs-CRP (percent change: -35.45 vs. 36.76%; P = 0.05). However, this effect was not significant after adjusting for the confounding variable (carbohydrate intake).
   CONCLUSIONS-Soy milk consumption could decrease serum D-dimer level among type 2 diabetic patients with nephropathy. However, markers of inflammation and oxidative stress did not change following soy milk intake among these patients.
C1 [Miraghajani, Maryam Sadat; Esmaillzadeh, Ahmad; Mirlohi, Maryam; Azadbakht, Leila] Isfahan Univ Med Sci, Food Secur Res Ctr, Esfahan, Iran.
   [Miraghajani, Maryam Sadat; Esmaillzadeh, Ahmad; Azadbakht, Leila] Isfahan Univ Med Sci, Sch Nutr & Food Sci, Dept Community Nutr, Esfahan, Iran.
   [Najafabadi, Mojgan Mortazavi] Isfahan Univ Med Sci, Isfahan Kidney Dis Res Ctr, Esfahan, Iran.
   [Mirlohi, Maryam] Isfahan Univ Med Sci, Sch Nutr & Food Sci, Dept Food Sci & Technol, Esfahan, Iran.
C3 Isfahan University of Medical Sciences; Isfahan University of Medical
   Sciences; Isfahan University of Medical Sciences; Isfahan University of
   Medical Sciences
RP Azadbakht, L (corresponding author), Isfahan Univ Med Sci, Food Secur Res Ctr, Esfahan, Iran.
EM azadbakht@hlth.mui.ac.ir
RI Esmaillzadeh, Ahmad/N-5704-2014; Mortazavi, Mojgan/C-6553-2018;
   Azadbakht, Leila/N-2801-2018
OI Esmaillzadeh, Ahmad/0000-0002-8735-6047; Mortazavi,
   Mojgan/0000-0002-9636-2553; Azadbakht, Leila/0000-0002-5955-6818;
   Miraghajani, Maryam/0000-0002-8265-0335
FU Isfahan University of Medical Sciences, Isfahan, Iran
FX This study was supported by the Isfahan University of Medical Sciences,
   Isfahan, Iran.
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NR 35
TC 69
Z9 72
U1 0
U2 15
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0149-5992
EI 1935-5548
J9 DIABETES CARE
JI Diabetes Care
PD OCT
PY 2012
VL 35
IS 10
BP 1981
EP 1985
DI 10.2337/dc12-0250
PG 5
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 013KO
UT WOS:000309304500005
PM 22787172
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Fan, XL
   Gu, CG
   Gao, ZY
   Shen, LZ
   Yang, XL
   Song, Y
   Bian, YR
   Xu, QF
   Wang, F
   Jiang, X
AF Fan, Xiuli
   Gu, Chenggang
   Gao, Zhengyuan
   Shen, Lezu
   Yang, Xinglun
   Song, Yang
   Bian, Yongrong
   Xu, Qingfeng
   Wang, Fang
   Jiang, Xin
TI Active binding mechanism to superoxide dismutase and toxicological
   implication for environmentally prevalent phthalates and their
   hydrolytic products: Coupling in vitro bioassay with molecular dynamics
   simulation
SO INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
LA English
DT Article
DE Phthalic acid esters; Superoxide dismutase; Molecular dynamics;
   Catalytic channel; Arg141
ID ELECTROSTATIC LOOP; COPPER; EXPOSURE; ACCURACY; PATHWAYS; SYSTEM; MODELS
AB Phthalic acid esters (PAEs) are widely used as plasticizers to improve the flexibility and durability of plastics. However, their environmental presence poses risks by inducing oxidative stress and contributing to metabolic syndrome. Despite being linked to various diseases, the mechanisms by which PAEs disrupt antioxidant enzymes, particularly superoxide dismutase (SOD), are not well understood. This study investigated the molecular interactions between PAEs, their metabolites, and SOD using bioassays and theoretical simulations. The results showed that key metabolites, monophthalates (MAEs) and phthalic acid (PA), strongly inhibited SOD activity, with potency increasing as side chain length decreased. In contrast, PAEs caused minor changes in SOD activity. The inhibition resulted from tight binding of MAEs and PA to the residues in the enzyme's bottom cavity. PAEs and metabolites induced significant structural changes in the secondary structures, catalytic channel, and hydrogen bond network, destabilizing the protein and impairing its function. A strong correlation between SOD inhibition and Gibbs free binding energies at Arg141 was observed. Arg141 and allelic residues can serve as biomarkers for early warnings of oxidative stress. This study improves our understanding of oxidative stress mechanisms caused by PAEs and emphasizes the need for better risk management of phthalate exposure.
C1 [Fan, Xiuli; Gu, Chenggang; Gao, Zhengyuan; Shen, Lezu; Yang, Xinglun; Song, Yang; Bian, Yongrong; Wang, Fang; Jiang, Xin] Chinese Acad Sci, Inst Soil Sci, State Key Lab Soil & Sustainable Agr, Nanjing 210008, Peoples R China.
   [Fan, Xiuli; Gu, Chenggang; Gao, Zhengyuan; Shen, Lezu; Yang, Xinglun; Song, Yang; Bian, Yongrong; Wang, Fang; Jiang, Xin] Univ Chinese Acad Sci, Beijing 100049, Peoples R China.
   [Xu, Qingfeng] Soochow Univ, Suzhou 215123, Peoples R China.
C3 Chinese Academy of Sciences; Nanjing Institute of Soil Science, CAS;
   Chinese Academy of Sciences; University of Chinese Academy of Sciences,
   CAS; Soochow University - China
RP Gu, CG (corresponding author), Chinese Acad Sci, Inst Soil Sci, State Key Lab Soil & Sustainable Agr, Nanjing 210008, Peoples R China.
EM cggu@issas.ac.cn
RI Gao, Zhengyuan/CAH-0511-2022
FU National Key Research and Development Program of China [2023YFC3706702];
   National Natural Science Foundation of China [42377406, 21377138];
   Strategic Priority Research Program of the Chinese Academy of Sciences
   [XDA28030501]; Self-Deployment Project of Institute of Soil Science,
   Chinese Academy of Sciences [ISSAS2419];  [41977356]
FX The work was financially supported by National Key Research and
   Development Program of China (2023YFC3706702) , National Natural Science
   Foundation of China (Nos. 42377406, 41977356, and 21377138) , Strategic
   Priority Research Program of the Chinese Academy of Sciences
   (XDA28030501) and Self-Deployment Project of Institute of Soil Science,
   Chinese Academy of Sciences (ISSAS2419) .
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NR 81
TC 0
Z9 0
U1 4
U2 4
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0141-8130
EI 1879-0003
J9 INT J BIOL MACROMOL
JI Int. J. Biol. Macromol.
PD JUN
PY 2025
VL 311
AR 143607
DI 10.1016/j.ijbiomac.2025.143607
PN 1
PG 11
WC Biochemistry & Molecular Biology; Chemistry, Applied; Polymer Science
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry; Polymer Science
GA 2LY3C
UT WOS:001485801400002
PM 40306524
DA 2025-06-11
ER

PT J
AU Ruggeri, RM
   Barbalace, MC
   Croce, L
   Malaguti, M
   Campennì, A
   Rotondi, M
   Cannavò, S
   Hrelia, S
AF Ruggeri, Rosaria Maddalena
   Barbalace, Maria Cristina
   Croce, Laura
   Malaguti, Marco
   Campenni, Alfredo
   Rotondi, Mario
   Cannavo, Salvatore
   Hrelia, Silvana
TI Autoimmune Thyroid Disorders: The Mediterranean Diet as a Protective
   Choice
SO NUTRIENTS
LA English
DT Review
DE autoimmune thyroid diseases; Hashimoto's thyroiditis; Mediterranean
   diet; Western diet; vegetarianism; oxidative stress
ID FIBROBLAST-LIKE SYNOVIOCYTES; ULTRA-PROCESSED FOODS; VITAMIN-D; SELENIUM
   SUPPLEMENTATION; HASHIMOTOS-THYROIDITIS; METABOLIC SYNDROME; OXIDATIVE
   STRESS; OLIVE OIL; IODINE-DEFICIENCY; LIPID MEDIATORS
AB Autoimmune thyroid diseases are on the rise worldwide, and such a rapid increase is mainly driven by environmental factors related to changed lifestyles in "modern" societies. In this context, diet seems to play a crucial role. An unhealthy high-energy diet, rich in animal fat and proteins, salt and refined sugars (the so-called "Western diet") negatively influences the risk of autoimmunity by altering the immune balance and the gut microbiota composition, enhancing oxidative stress and promoting inflammation. In contrast, the Mediterranean diet represents a unique model of healthy eating, characterized by a high intake of food from vegetable sources, a low consumption of saturated fats in favor of unsaturated fats (mainly, olive oil), a moderate consumption of fish (typically, the small oily fishes) and dairy products, as well as a moderate consumption of wine at meals, and a low intake of meat. Thanks to its nutritional components, the Mediterranean Diet positively influences immune system function, gut microbiota composition, and redox homeostasis, exerting anti-oxidants, anti-inflammatory, and immunomodulatory effects. The present review was aimed at exploring the existing knowledge on the correlations between dietary habits and thyroid autoimmunity, to evaluate the role of the Mediterranean diet as a protective model.
C1 [Ruggeri, Rosaria Maddalena; Cannavo, Salvatore] Univ Messina, Dept Human Pathol Adulthood & Childhood DETEV G Ba, Endocrinol Unit, I-98125 Messina, Italy.
   [Barbalace, Maria Cristina; Malaguti, Marco; Hrelia, Silvana] Univ Bologna, Dept Life Qual Studies, Alma Mater Studiorum, I-40126 Bologna, Italy.
   [Croce, Laura; Rotondi, Mario] Univ Pavia, Dept Internal Med & Therapeut, Unit Endocrinol & Metab, Ist Clin Sci Maugeri,Lab Endocrine Disruptors,Ist, I-27100 Pavia, Italy.
   [Campenni, Alfredo] Univ Messina, Dept Biomed & Dent Sci & Morpho Funct Imaging, Unit Nucl Med, I-98124 Messina, Italy.
C3 University of Messina; University of Bologna; University of Pavia;
   Istituti Clinici Scientifici Maugeri IRCCS; University of Messina
RP Ruggeri, RM (corresponding author), Univ Messina, Dept Human Pathol Adulthood & Childhood DETEV G Ba, Endocrinol Unit, I-98125 Messina, Italy.
EM rmruggeri@unime.it; maria.barbalace2@unibo.it;
   laura.croce@icsmaugeri.it; mario.rotondi@icsmaugeri.it;
   silvana.hrelia@unibo.it
RI Croce, Laura/AAC-8996-2019; Campennì, Alfredo/P-4067-2016; Barbalace,
   Maria Cristina/GLU-3550-2022; Ruggeri, Rosaria/AAB-7364-2019; Malaguti,
   Marco/K-5994-2015; Cannavo, Salvatore/D-7608-2013; rotondi,
   mario/K-5250-2016
OI CAMPENNI', Alfredo/0000-0002-0177-939X; Barbalace, Maria
   Cristina/0000-0001-5686-0470; RUGGERI, Rosaria
   Maddalena/0000-0001-8899-684X; Cannavo, Salvatore/0000-0001-8779-7283;
   rotondi, mario/0000-0001-6464-2334
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TC 15
Z9 16
U1 6
U2 23
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD SEP
PY 2023
VL 15
IS 18
AR 3953
DI 10.3390/nu15183953
PG 22
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA T4SU6
UT WOS:001077911100001
PM 37764737
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Guo, J
   Xu, FR
   Xie, Y
   Chen, B
   Wang, Y
   Nie, W
   Zhou, K
   Zhou, H
   Xu, BC
AF Guo, Jie
   Xu, Feiran
   Xie, Yong
   Chen, Bo
   Wang, Ying
   Nie, Wen
   Zhou, Kai
   Zhou, Hui
   Xu, Baocai
TI Effect of Xuanwei Ham Proteins with Different Ripening Periods on Lipid
   Metabolism, Oxidative Stress, and Gut Microbiota in Mice
SO MOLECULAR NUTRITION & FOOD RESEARCH
LA English
DT Article
DE antioxidation; intestine microbiota; lipid metabolism; ripening period;
   Xuanwei ham protein
ID FATTY-ACID OXIDATION; CURED-HAM; BIOACTIVE PEPTIDES; DIETARY-PROTEIN;
   HEALTH; ANTIOXIDANT; KINASE; IMPACT; DIGESTIBILITY; CONSUMPTION
AB Scope Consumption of dry-cured ham may have a cardiovascular disease preventive capacity. However, whether ham protein in the maintenance of health and prevention of disease is dependent on ripening periods need to be clarified. Methods and results Fifty C57BL/6 mice consume a diet that contains either Casein, raw ham protein (XWH0), or Xuanwei ham protein after 1-, 2-, or 3-years of maturation (XWH1, XWH2, or XWH3) for 4 weeks. Results show that longer ripening periods in the Xuanwei ham groups are negatively correlated with body weight gain, adipose tissue weight, total cholesterol (TC), and triglycerides levels in serum and liver, and these proteins intake could maintain liver health, reduce lipid deposition and oxidative stress, regulate lipid metabolism-related genes expression, alter the gut microbiota, and promote short-chain fatty acid production. Remarkably, XWH3 intake maintains lower TC and low-density lipoprotein cholesterol levels in serum and has high antioxidative activity as well. This regulation of lipid metabolism and oxidative stress may be related to the AMPK/Nrf2 signaling. Conclusion Xuanwei ham dietary proteins that have endured a specific ripening period may have preventive effects on metabolic syndrome, which provide a basis for new ideas for nutritional health interventions.
C1 [Guo, Jie; Xu, Feiran; Xie, Yong; Chen, Bo; Wang, Ying; Nie, Wen; Zhou, Kai; Zhou, Hui; Xu, Baocai] Hefei Univ Technol, Sch Food & Biol Engn, Hefei 230601, Peoples R China.
   [Guo, Jie; Xu, Feiran; Xie, Yong; Chen, Bo; Wang, Ying; Nie, Wen; Zhou, Kai; Zhou, Hui; Xu, Baocai] Hefei Univ Technol, Minist Educ, Engn Res Ctr Bioproc, Hefei 230601, Peoples R China.
   [Xu, Feiran] Anhui Qingsong Food Co Ltd, 28 Ningxi Rd, Hefei 231299, Peoples R China.
C3 Hefei University of Technology; Hefei University of Technology; Ministry
   of Education - China
RP Xu, BC (corresponding author), Hefei Univ Technol, Sch Food & Biol Engn, Hefei 230601, Peoples R China.; Xu, BC (corresponding author), Hefei Univ Technol, Minist Educ, Engn Res Ctr Bioproc, Hefei 230601, Peoples R China.
EM baocaixu@163.com
RI yong, xie/HLH-0768-2023; Zhou, Kai/IXD-9365-2023
OI Zhou, Kai/0000-0003-0061-7927; Nie, Wen/0000-0001-7803-7733
FU National Natural Science Foundation of China [32102035]; Natural Science
   Foundation of Anhui, China [2008085QC144]; Anhui Qingsong Food Co., Ltd.
   [W2021JSKF0780]
FX The authors thank all the current and former Meat Processing and
   Nutrition lab members for their support and advise during execution of
   this research. The authors thank professor Conggui Chen, associate
   professor Peijun Li, and lecturer Zhaoming Wang from HFUT for their help
   during the experiment. This project was supported by the National
   Natural Science Foundation of China (No. 32102035), the Natural Science
   Foundation of Anhui, China (No. 2008085QC144) and the cooperation
   project from Anhui Qingsong Food Co., Ltd. (W2021JSKF0780).
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NR 85
TC 4
Z9 4
U1 2
U2 34
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1613-4125
EI 1613-4133
J9 MOL NUTR FOOD RES
JI Mol. Nutr. Food Res.
PD SEP
PY 2022
VL 66
IS 18
AR 2101020
DI 10.1002/mnfr.202101020
EA AUG 2022
PG 14
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA 4S8SV
UT WOS:000837797400001
PM 35872655
DA 2025-06-11
ER

PT J
AU Seo, KH
   Bartley, GE
   Tam, C
   Kim, HS
   Kim, DH
   Chon, JW
   Kim, H
   Yokoyama, W
AF Seo, Kun-Ho
   Bartley, Glenn E.
   Tam, Christina
   Kim, Hong-Seok
   Kim, Dong-Hyeon
   Chon, Jung-Whan
   Kim, Hyunsook
   Yokoyama, Wallace
TI Chardonnay Grape Seed Flour Ameliorates Hepatic Steatosis and Insulin
   Resistance via Altered Hepatic Gene Expression for Oxidative Stress,
   Inflammation, and Lipid and Ceramide Synthesis in Diet-Induced Obese
   Mice
SO PLOS ONE
LA English
DT Article
ID FATTY LIVER-DISEASE; ADIPOSE-TISSUE; HYDROXYPROPYL METHYLCELLULOSE;
   NONALCOHOLIC STEATOHEPATITIS; PLASMA-CHOLESTEROL; METABOLIC SYNDROME;
   DEFICIENT MICE; WEIGHT-LOSS; GREEN TEA; EXTRACT
AB To identify differentially expressed hepatic genes contributing to the improvement of high-fat (HF) diet-induced hepatic steatosis and insulin resistance following supplementation of partially defatted flavonoid-rich Chardonnay grape seed flour (ChrSd), diet-induced obese (DIO) mice were fed HF diets containing either ChrSd or microcrystalline cellulose (MCC, control) for 5 weeks. The 2-h insulin area under the curve was significantly lowered by ChrSd, indicating that ChrSd improved insulin sensitivity. ChrSd intake also significantly reduced body weight gain, liver and adipose tissue weight, hepatic lipid content, and plasma low-density lipoprotein (LDL)-cholesterol, despite a significant increase in food intake. Exon microarray analysis of hepatic gene expression revealed down-regulation of genes related to triglyceride and ceramide synthesis, immune response, oxidative stress, and inflammation and upregulation of genes related to fatty acid oxidation, cholesterol, and bile acid synthesis. In conclusion, the effects of ChrSd supplementation in a HF diet on weight gain, insulin resistance, and progression of hepatic steatosis in DIO mice were associated with modulation of hepatic genes related to oxidative stress, inflammation, ceramide synthesis, and lipid and cholesterol metabolism.
C1 [Seo, Kun-Ho; Kim, Hong-Seok; Kim, Dong-Hyeon; Chon, Jung-Whan] Konkuk Univ, Coll Vet Med, Seoul, South Korea.
   [Bartley, Glenn E.; Tam, Christina; Yokoyama, Wallace] ARS, USDA, Albany, CA USA.
   [Kim, Hyunsook] Hanyang Univ, Dept Food & Nutr, Seoul, South Korea.
C3 Konkuk University; United States Department of Agriculture (USDA);
   Hanyang University
RP Kim, H (corresponding author), Hanyang Univ, Dept Food & Nutr, Seoul, South Korea.
EM hyunsk15@hanyang.ac.kr
RI Kim, Hanjun/AAJ-7528-2021; Kim, Hyuk Soon/IQW-9348-2023; Seo,
   Kun-Ho/AAQ-2666-2020
OI Kim, Hyunsook/0000-0001-7345-4167; Kim, Dong-Hyeon/0000-0003-0585-2432
FU National Research Foundation of Korea (NRF) - Korea government (MSIP)
   [2015R1A2A2A01005017]; National Institute of Food and Agriculture (NIFA)
   Small Business Innovation Research Program Phase I grant (NIFA/SBIR)
   [2013-00549]; Formas [2013-00549] Funding Source: Formas
FX This work was supported by the National Research Foundation of Korea
   (NRF) grant funded by the Korea government (MSIP)
   (No.2015R1A2A2A01005017) and partly by a National Institute of Food and
   Agriculture (NIFA) Small Business Innovation Research Program Phase I
   grant (NIFA/SBIR 2013-00549).
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JI PLoS One
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DA 2025-06-11
ER

PT J
AU Bechmann, LP
   Hannivoort, RA
   Gerken, G
   Hotamisligil, GS
   Trauner, M
   Canbay, A
AF Bechmann, Lars P.
   Hannivoort, Rebekka A.
   Gerken, Guido
   Hotamisligil, Goekhan S.
   Trauner, Michael
   Canbay, Ali
TI The interaction of hepatic lipid and glucose metabolism in liver
   diseases
SO JOURNAL OF HEPATOLOGY
LA English
DT Review
DE NAFLD; Fatty acid transporters; HCC; Liver regeneration; Nuclear
   receptors; ER stress
ID ENDOPLASMIC-RETICULUM STRESS; FARNESOID X-RECEPTOR; ELEMENT-BINDING
   PROTEIN-1C; INSULIN SIGNALING PATHWAY; DE-NOVO LIPOGENESIS; FATTY-ACID
   UPTAKE; NF-KAPPA-B; NONALCOHOLIC STEATOHEPATITIS;
   HEPATOCELLULAR-CARCINOMA; PPAR-ALPHA
AB It is widely known that the liver is a central organ in lipogenesis, gluconeogenesis and cholesterol metabolism. However, over the last decades, a variety of pathological conditions highlighted the importance of metabolic functions within the diseased liver. As observed in Western societies, an increase in the prevalence of obesity and the metabolic syndrome promotes pathophysiological changes that cause non-alcoholic fatty liver disease (NAFLD). NAFLD increases the susceptibility of the liver to acute liver injury and may lead to cirrhosis and hepatocellular cancer. Alterations in insulin response, beta-oxidation, lipid storage and transport, autophagy and an imbalance in chemokines and nuclear receptor signaling are held accountable for these changes. Furthermore, recent studies revealed a role for lipid accumulation in inflammation and ER stress in the clinical context of liver regeneration and hepatic carcinogenesis. This review focuses on novel findings related to nuclear receptor signaling - including the vitamin D receptor and the liver receptor homolog 1 - in hepatic lipid and glucose uptake, storage and metabolism in the clinical context of NAFLD, liver regeneration, and cancer. (C) 2012 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
C1 [Bechmann, Lars P.; Gerken, Guido; Canbay, Ali] Univ Duisburg Essen, Dept Gastroenterol & Hepatol, Univ Hosp Essen, D-45122 Essen, Germany.
   [Hannivoort, Rebekka A.] Univ Groningen, Dept Gastroenterol & Hepatol, Univ Med Ctr Groningen, Groningen, Netherlands.
   [Hotamisligil, Goekhan S.] Harvard Univ, Sch Publ Hlth, Dept Genet, Boston, MA 02115 USA.
   [Hotamisligil, Goekhan S.] Harvard Univ, Sch Publ Hlth, Dept Complex Dis & Nutr, Boston, MA 02115 USA.
   [Trauner, Michael] Med Univ Vienna, Div Gastroenterol & Hepatol, Dept Internal Med 3, Vienna, Austria.
C3 University of Duisburg Essen; University of Groningen; Harvard
   University; Harvard T.H. Chan School of Public Health; Harvard
   University; Harvard T.H. Chan School of Public Health; Medical
   University of Vienna
RP Canbay, A (corresponding author), Univ Duisburg Essen, Dept Gastroenterol & Hepatol, Univ Hosp Essen, Hufelandstr 55, D-45122 Essen, Germany.
EM ali.canbay@uni-due.de
RI Canbay, Ali/AAL-9620-2020; Bechmann, Lars/AAZ-7141-2020; Trauner,
   Michael/HCH-4032-2022; Hotamisligil, Gokhan/ABL-2919-2022
OI Gerken, Guido/0000-0001-6734-5001; Canbay, Ali/0000-0001-6069-7899;
   Trauner, Michael/0000-0002-1275-6425; Bechmann, Lars/0000-0003-3487-9810
FU Deutsche Forschungsgemeinschaft (DFG) [267/6-1, 267/8-1]; Wilhelm
   Laupitz Foundation; EASL; IFORES of the University of Duisburg-Essen;
   IFORES
FX The authors do not have a relationship with the manufacturers of the
   drugs involved either in the past or present and did not receive funding
   from the manufacturers to carry out their research. The authors received
   support from DFG, Wilhelm Laupitz Foundation, EASL, and IFORES.AC is
   supported by the Deutsche Forschungsgemeinschaft (DFG, grant 267/6-1 and
   267/8-1), and the Wilhelm Laupitz Foundation. LPB is supported by an
   EASL Sheila Sherlock short-term fellowship and the IFORES Program of the
   University of Duisburg-Essen.
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WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 918SY
UT WOS:000302272600026
PM 22173168
OA hybrid
DA 2025-06-11
ER

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   de Leon, Jose
TI A combined analysis of worldwide studies demonstrates an association
   between bipolar disorder and tobacco smoking behaviors in adults
SO BIPOLAR DISORDERS
LA English
DT Review
DE bipolar disorder; major depression; meta-analysis; nicotine;
   schizophrenia; smoking; tobacco
ID CARDIOVASCULAR RISK-FACTORS; FAGERSTROM TOLERANCE QUESTIONNAIRE;
   NATIONAL EPIDEMIOLOGIC SURVEY; CORONARY-HEART-DISEASE;
   CIGARETTE-SMOKING; NICOTINE DEPENDENCE; MENTAL ILLNESSES; METABOLIC
   SYNDROME; SUICIDAL-BEHAVIOR; I DISORDER
AB ObjectivesWorldwide studies were combined to examine two hypotheses: (i) bipolar disorder is associated with smoking behaviors, compared with the general population; and (ii) smoking behavior prevalences in bipolar disorder are intermediate between those in major depressive disorder and those in schizophrenia.
   MethodsCombined analyses used 56 articles on adults obtained from a PubMed search or the senior author's article collection. Odds ratios (ORs) and their 95% confidence intervals (CIs) compared current smoking, heavy smoking among current smokers, smoking cessation in ever smokers, and ever smoking in bipolar disorder versus control groups.
   ResultsThe combined OR was 3.5 (CI: 3.39-3.54) in 51 current smoking studies of bipolar disorder versus the general population from 16 countries. More limited data provided an OR=0.34 (CI: 0.31-0.37) for smoking cessation and an OR=3.6 (CI: 3.30-3.80) for ever smoking. The combined OR was 0.76 (CI: 0.74-0.79) for current smoking in bipolar disorder versus schizophrenia in 20 studies from ten countries. Ever smoking may be lower in bipolar disorder than in schizophrenia (OR=0.83, CI: 0.75-0.91). The OR was 2.05 (CI: 2.00-2.10) for current smoking in bipolar disorder versus major depression in 18 studies from seven countries. Ever smoking may be higher (OR=1.5, CI: 1.40-1.70) and smoking cessation lower (OR=0.51, CI: 0.45-0.59) in bipolar disorder than in major depression.
   ConclusionsIncreased current smoking in bipolar disorder versus the general population reflected increased ever smoking (initiation) and decreased smoking cessation. Smoking behavior frequencies in bipolar disorder may be between those in depressive disorder and schizophrenia, with schizophrenia showing the highest severity level.
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   [de Leon, Jose] Univ Basque Country, Santiago Apostol Hosp, Biomed Res Ctr Mental Hlth Net CIBERSAM, Vitoria, Spain.
C3 University of Kentucky; University of Kansas; University of Kansas
   Medical Center; Universidad Pontificia Bolivariana; University of
   Kentucky; University of Granada; CIBER - Centro de Investigacion
   Biomedica en Red; CIBERSAM; University of Basque Country
RP de Leon, J (corresponding author), Eastern State Hosp, UK Mental Hlth Res Ctr, 1350 Bull Lea Rd, Lexington, KY 40511 USA.
EM jdeleon@uky.edu
RI de Leon, Jose/F-2709-2013
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NR 125
TC 86
Z9 90
U1 0
U2 15
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1398-5647
EI 1399-5618
J9 BIPOLAR DISORD
JI Bipolar Disord.
PD SEP
PY 2015
VL 17
IS 6
BP 575
EP 597
DI 10.1111/bdi.12319
PG 23
WC Clinical Neurology; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA CQ8DB
UT WOS:000360835300001
PM 26238269
DA 2025-06-11
ER

PT J
AU Nabavi, SF
   Russo, GL
   Daglia, M
   Nabavi, SM
AF Nabavi, Seyed Fazel
   Russo, Gian Luigi
   Daglia, Maria
   Nabavi, Seyed Mohammad
TI Role of quercetin as an alternative for obesity treatment: You are what
   you eat!
SO FOOD CHEMISTRY
LA English
DT Review
DE Antioxidants; Obesity; Quercetin; Mitogen-activated protein kinase;
   Adenine monophosphate-activated protein kinase
ID ACTIVATED PROTEIN-KINASE; INDUCED OXIDATIVE STRESS; BODY-MASS INDEX;
   FLAVONOID QUERCETIN; METABOLIC SYNDROME; ADIPOSE-TISSUE;
   INSULIN-RESISTANCE; SMALL-INTESTINE; GLUCOSE-UPTAKE; INFLAMMATION
AB Obesity is one of the most serious global health problems, which increases the risk of other different chronic diseases. The crucial role of oxidative stress in the initiation and progression of obesity leads to the hypothesis that antioxidants can be used as therapeutic agents for obesity treatment. Among antioxidants, much attention has been paid to polyphenols due to their negligible adverse effects. Among them, quercetin is one of the most common dietary antioxidants widely distributed in different plant materials, such as fruits, vegetables and cereals. Quercetin shows a wide range of biological and health-promoting effects, such as anticancer, hepatoprotective, antidiabetic, anti-inflammatory and antibacterial activities. Furthermore, quercetin has anti-obesity activity through mitogen-activated protein kinase and adenine monophosphate-activated protein kinase signaling pathways. In this study, we reviewed the available scientific reports concerning the beneficial role of quercetin against obesity with emphasis on its mechanisms of action. (C) 2015 Elsevier Ltd. All rights reserved.
C1 [Nabavi, Seyed Fazel; Nabavi, Seyed Mohammad] Baqiyatallah Univ Med Sci, Appl Biotechnol Res Ctr, Tehran, Iran.
   [Russo, Gian Luigi] CNR, Inst Food Sci, I-83100 Avellino, Italy.
   [Daglia, Maria] Univ Pavia, Dept Drug Sci, Med Chem & Pharmaceut Technol Sect, I-27100 Pavia, Italy.
C3 Baqiyatallah University of Medical Sciences (BMSU); Consiglio Nazionale
   delle Ricerche (CNR); Istituto di Scienze dell' Alimentazione (ISA-CNR);
   University of Pavia
RP Daglia, M (corresponding author), Baqiyatallah Univ Med Sci, Appl Biotechnol Res Ctr, POB 19395-5487, Tehran, Iran.
EM maria.daglia@unipv.it; Nabavi208@gmail.com
RI Daglia, Maria/AAC-9498-2019; Nabavi, Seyed Mohammad/G-5335-2010; nabavi,
   seyed fazel/A-2223-2010; RUSSO, GIAN LUIGI/D-6333-2012
OI Daglia, Maria/0000-0002-4870-7713; RUSSO, GIAN LUIGI/0000-0001-9321-1613
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NR 76
TC 254
Z9 268
U1 6
U2 280
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0308-8146
EI 1873-7072
J9 FOOD CHEM
JI Food Chem.
PD JUL 15
PY 2015
VL 179
BP 305
EP 310
DI 10.1016/j.foodchem.2015.02.006
PG 6
WC Chemistry, Applied; Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Food Science & Technology; Nutrition & Dietetics
GA CF9ZM
UT WOS:000352926400038
PM 25722169
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Cioffi, F
   Senese, R
   Lasala, P
   Ziello, A
   Mazzoli, A
   Crescenzo, R
   Liverini, G
   Lanni, A
   Goglia, F
   Iossa, S
AF Cioffi, Federica
   Senese, Rosalba
   Lasala, Pasquale
   Ziello, Angela
   Mazzoli, Arianna
   Crescenzo, Raffaella
   Liverini, Giovanna
   Lanni, Antonia
   Goglia, Fernando
   Iossa, Susanna
TI Fructose-Rich Diet Affects Mitochondrial DNA Damage and Repair in Rats
SO NUTRIENTS
LA English
DT Article
DE fructose-rich diet; mitochondrial biogenesis; mitochondrial DNA (mtDNA);
   oxidative damage; repair mechanisms
ID FATTY LIVER-DISEASE; OXIDATIVE STRESS; INSULIN-RESISTANCE; CORN SYRUP;
   INTESTINAL INFLAMMATION; HEPATIC MITOCHONDRIAL; METABOLIC SYNDROME;
   GLUCOSE; PATHOGENESIS; CONSUMPTION
AB Evidence indicates that many forms of fructose-induced metabolic disturbance are associated with oxidative stress and mitochondrial dysfunction. Mitochondria are prominent targets of oxidative damage; however, it is not clear whether mitochondrial DNA (mtDNA) damage and/or its lack of repair are events involved in metabolic disease resulting from a fructose-rich diet. In the present study, we evaluated the degree of oxidative damage to liver mtDNA and its repair, in addition to the state of oxidative stress and antioxidant defense in the liver of rats fed a high-fructose diet. We used male rats feeding on a high-fructose or control diet for eight weeks. Our results showed an increase in mtDNA damage in the liver of rats fed a high-fructose diet and this damage, as evaluated by the expression of DNA polymerase gamma, was not repaired; in addition, the mtDNA copy number was found to be significantly reduced. A reduction in the mtDNA copy number is indicative of impaired mitochondrial biogenesis, as is the finding of a reduction in the expression of genes involved in mitochondrial biogenesis. In conclusion, a fructose-rich diet leads to mitochondrial and mtDNA damage, which consequently may have a role in liver dysfunction and metabolic diseases.
C1 [Cioffi, Federica; Lasala, Pasquale; Goglia, Fernando] Univ Sannio, Dept Sci & Technol, I-82100 Benevento, Italy.
   [Senese, Rosalba; Ziello, Angela; Lanni, Antonia] Univ Naples 2, Dept Environm Biol & Pharmaceut Sci & Technol, I-81100 Caserta, Italy.
   [Mazzoli, Arianna; Crescenzo, Raffaella; Liverini, Giovanna; Iossa, Susanna] Univ Naples Federico II, Dept Biol, I-80100 Naples, Italy.
C3 University of Sannio; Universita della Campania Vanvitelli; University
   of Naples Federico II
RP Goglia, F (corresponding author), Univ Sannio, Dept Sci & Technol, I-82100 Benevento, Italy.
EM federica.cioffi@unisannio.it; rosalba.senese@unina2.it;
   pasquale.lasala@gmail.com; angela.ziello@gmail.com;
   arimazzoli@hotmail.it; rcrescen@unina.it; liverini@unina.it;
   antonia.lanni@unina2.it; goglia@unisannio.it; susiossa@unina.it
RI cioffi, federica/AAB-8161-2019; IOSSA, Susanna/O-1625-2016
OI LANNI, Antonia/0000-0001-5797-0348; CIOFFI,
   Federica/0000-0002-1530-8556; IOSSA, Susanna/0000-0001-6103-718X;
   SENESE, Rosalba/0000-0003-1571-0980; mazzoli,
   arianna/0000-0003-4096-443X
FU University of Sannio; University of Napoli "Federico II"
FX This research was financially supported by a "FAR" grant from the
   University of Sannio and by a grant from the University of Napoli
   "Federico II".
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PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 2072-6643
J9 NUTRIENTS
JI Nutrients
PD APR
PY 2017
VL 9
IS 4
AR 323
DI 10.3390/nu9040323
PG 14
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA EU9JI
UT WOS:000401355600008
PM 28338610
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Podrini, C
   Borghesan, M
   Greco, A
   Pazienza, V
   Mazzoccoli, G
   Vinciguerra, M
AF Podrini, Christine
   Borghesan, Michela
   Greco, Azzura
   Pazienza, Valerio
   Mazzoccoli, Gianluigi
   Vinciguerra, Manlio
TI Redox Homeostasis and Epigenetics in Non-alcoholic Fatty Liver Disease
   (NAFLD)
SO CURRENT PHARMACEUTICAL DESIGN
LA English
DT Article
DE Non-alcoholic fatty liver disease (NAFLD); epigenetics; oxidative stress
ID ACTIVATED PROTEIN-KINASE; HEPATIC STEATOSIS; INSULIN-RESISTANCE;
   MITOCHONDRIAL DYSFUNCTION; METABOLIC SYNDROME; OXIDATIVE STRESS;
   ACID-METABOLISM; DOWN-REGULATION; HISTONE DEACETYLASE;
   LIPID-ACCUMULATION
AB Non-alcoholic fatty liver disease (NAFLD), an accumulation of intra-hepatic triglycerides that is often considered the hepatic manifestation of insulin resistance, is the most common cause of chronic liver disease in the Western countries with up to one third of the population affected. NAFLD is a spectrum of disturbances that encompasses various degrees of liver damage ranging from simple steatosis to non-alcoholic steatohepatitis (NASH). NASH is characterized by hepatocellular injury/inflammation with or without fibrosis. The individuals with NAFLD develop NASH in 10% of the cases, and are also at risk of developing hepatocellular carcinoma (HCC). Epigenetic mechanisms of nuclear chromatin remodeling, such as DNA methylation, post-translational modifications of histones, and incorporation of histone variants into the chromatin are increasingly recognized as crucial factors in the pathophysiology of NAFLD. NAFLD is often accompanied by oxidative stress: reactive oxygen species (ROS) are implicated in altered reduction/oxidation (redox) reactions that attack cellular macromolecules and are detected in the liver of patients and animal models of NAFLD. In this review, we summarize recent knowledge advancements in the hepatic epigenetic and redox mechanisms, and their possible links, involved in the pathogenesis and treatment of NAFLD.
C1 [Podrini, Christine; Borghesan, Michela; Greco, Azzura] Fdn Liver Res, Inst Hepatol, London WC1E 6HX, England.
   [Pazienza, Valerio] IRCCS Casa Sollievo Sofferenza, Div & Lab Gastroenterol, San Giovanni Rotondo, Italy.
   [Mazzoccoli, Gianluigi] IRCCS Casa Sollievo Sofferenza, Dept Internal Med Unit, San Giovanni Rotondo, Italy.
   [Vinciguerra, Manlio] EuroMediterranean Inst Sci & Technol IEMEST, Palermo, Italy.
   [Vinciguerra, Manlio] UCL Inst Liver & Digest Hlth, Div Med, London, England.
C3 University of London; University College London; IRCCS Casa Sollievo
   Della Sofferenza; IRCCS Casa Sollievo Della Sofferenza; University of
   London; University College London
RP Vinciguerra, M (corresponding author), Fdn Liver Res, Inst Hepatol, 69-75 Chenies Mews, London WC1E 6HX, England.
EM m.vinciguerra@ucl.ac.uk
RI Pazienza, Valerio/K-5073-2012; Vinciguerra, Manlio/N-1309-2015;
   Mazzoccoli, Gianluigi Ubaldo/H-2447-2016; Podrini, Christine/K-8621-2016
OI Borghesan, Michela/0000-0001-6432-4969; Mazzoccoli, Gianluigi
   Ubaldo/0000-0003-3535-7635; Pazienza, Valerio/0000-0002-3492-1153;
   Podrini, Christine/0000-0002-5391-3378; Vinciguerra,
   Manlio/0000-0002-1768-3894
FU Foundation for Liver Research (London, UK)
FX M.V. is supported by the Foundation for Liver Research (London, UK). We
   are grateful to Giuseppe Costanza for preparing the illustration.
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NR 165
TC 84
Z9 87
U1 1
U2 56
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1381-6128
EI 1873-4286
J9 CURR PHARM DESIGN
JI Curr. Pharm. Design
PD MAY
PY 2013
VL 19
IS 15
BP 2737
EP 2746
DI 10.2174/1381612811319150009
PG 10
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 116BC
UT WOS:000316856300009
PM 23092327
DA 2025-06-11
ER

PT J
AU Burniston, JG
   Kenyani, J
   Wastling, JM
   Burant, CF
   Qi, NR
   Koch, LG
   Britton, SL
AF Burniston, Jatin G.
   Kenyani, Jenna
   Wastling, Jonathan M.
   Burant, Charles F.
   Qi, Nathan R.
   Koch, Lauren G.
   Britton, Steven L.
TI Proteomic analysis reveals perturbed energy metabolism and elevated
   oxidative stress in hearts of rats with inborn low aerobic capacity
SO PROTEOMICS
LA English
DT Article
DE 2-DE; Animal proteomics; Animal selection model; MS
ID ALPHA-B-CRYSTALLIN; ARTIFICIAL SELECTION; SIGNALING PATHWAYS;
   HYPERTROPHY; PROTEASOME; MUSCLE; PHOSPHORYLATION; SUSCEPTIBILITY;
   MICROTUBULES; MITOCHONDRIA
AB Selection on running capacity has created rat phenotypes of high-capacity runners (HCRs) that have enhanced cardiac function and low-capacity runners (LCRs) that exhibit risk factors of metabolic syndrome. We analysed hearts of HCRs and LCRs from generation 22 of selection using DIGE and identified proteins from MS database searches. The running capacity of HCRs was six-fold greater than LCRs. DIGE resolved 957 spots and proteins were unambiguously identified in 369 spots. Protein expression profiling detected 67 statistically significant (p<0.05; false discovery rate <10%, calculated using q-values) differences between HCRs and LCRs. Hearts of HCR rats exhibited robust increases in the abundance of each enzyme of the beta-oxidation pathway. In contrast, LCR hearts were characterised by the modulation of enzymes associated with ketone body or amino acid metabolism. LCRs also exhibited enhanced expression of antioxidant enzymes such as catalase and greater phosphorylation of alpha B-crystallin at serine 59, which is a common point of convergence in cardiac stress signalling. Thus, proteomic analysis revealed selection on low running capacity is associated with perturbations in cardiac energy metabolism and provided the first evidence that the LCR cardiac proteome is exposed to greater oxidative stress.
C1 [Burniston, Jatin G.] Liverpool John Moores Univ, Muscle Physiol & Prote Lab, Res Inst Sport & Exercise Sci, Liverpool L3 3AF, Merseyside, England.
   [Burniston, Jatin G.] Liverpool John Moores Univ, Inst Hlth Res, Liverpool L3 3AF, Merseyside, England.
   [Kenyani, Jenna; Wastling, Jonathan M.] Univ Liverpool, Inst Infect & Global Hlth, Liverpool L69 3BX, Merseyside, England.
   [Burant, Charles F.; Qi, Nathan R.; Koch, Lauren G.; Britton, Steven L.] Univ Michigan, Dept Internal Med, Ann Arbor, MI 48109 USA.
   [Koch, Lauren G.; Britton, Steven L.] Univ Michigan, Dept Anesthesiol, Ann Arbor, MI 48109 USA.
C3 Liverpool John Moores University; Liverpool John Moores University;
   University of Liverpool; University of Michigan System; University of
   Michigan; University of Michigan System; University of Michigan
RP Burniston, JG (corresponding author), Liverpool John Moores Univ, Muscle Physiol & Prote Lab, Res Inst Sport & Exercise Sci, Tom Reilly Bldg,Byrom St, Liverpool L3 3AF, Merseyside, England.
EM j.burniston@ljmu.ac.uk
RI Burant, Charles/GPC-5690-2022; Burniston, Jatin/AAB-8831-2020; Koch,
   Lauren/D-1258-2010
OI Burant, Charles/0000-0001-9189-5003
FU Institute for Health Research, Liverpool John Moores University;
   National Center for Research Resources of the National Institutes of
   Health and the Animal Phenotyping Core of the Michigan Metabolomics and
   Obesity Center [R17718, 5R01DK7720]
FX This work was supported by The Institute for Health Research, Liverpool
   John Moores University (J.G.B., L. G. K. and S. L. B.) and grants R17718
   (L. G. K. and S. L. B.) and 5R01DK7720 (C. F. B., S. L. B. and N.Q.)
   from the National Center for Research Resources of the National
   Institutes of Health and the Animal Phenotyping Core of the Michigan
   Metabolomics and Obesity Center.
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NR 42
TC 23
Z9 26
U1 0
U2 14
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1615-9853
EI 1615-9861
J9 PROTEOMICS
JI Proteomics
PD AUG
PY 2011
VL 11
IS 16
BP 3369
EP 3379
DI 10.1002/pmic.201000593
PG 11
WC Biochemical Research Methods; Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 814NN
UT WOS:000294463000010
PM 21751351
OA Green Accepted, Green Submitted
DA 2025-06-11
ER

PT J
AU Qasem, B
   Dabrowska, A
   Króliczewski, J
   Lyczko, J
   Marycz, K
AF Qasem, Badr
   Dabrowska, Agnieszka
   Kroliczewski, Jaroslaw
   Lyczko, Jacek
   Marycz, Krzysztof
TI Trodusquemine (MSI-1436) Restores Metabolic Flexibility and
   Mitochondrial Dynamics in Insulin-Resistant Equine Hepatic Progenitor
   Cells (HPCs)
SO CELLS
LA English
DT Article
DE MSI-1436; Eq_HPCs; glucose uptake; palmitate; mitochondrial
   dynamics/mitophagy
ID TYROSINE-PHOSPHATASE 1B; ENDOPLASMIC-RETICULUM STRESS; ELEMENT-BINDING
   PROTEINS; OXIDATIVE STRESS; GLUCOSE-PRODUCTION; ADIPOSE-TISSUE; KEY
   REGULATOR; STEM-CELLS; SIRT1; DYSFUNCTION
AB Equine metabolic syndrome (EMS) is a significant global health concern in veterinary medicine. There is increasing interest in utilizing molecular agents to modulate hepatocyte function for potential clinical applications. Recent studies have shown promising results in inhibiting protein tyrosine phosphatase (PTP1B) to maintain cell function in various models. In this study, we investigated the effects of the inhibitor Trodusquemine (MSI-1436) on equine hepatic progenitor cells (HPCs) under lipotoxic conditions. We examined proliferative activity, glucose uptake, and mitochondrial morphogenesis. Our study found that MSI-1436 promotes HPC entry into the cell cycle and protects them from palmitate-induced apoptosis by regulating mitochondrial dynamics and biogenesis. MSI-1436 also increases glucose uptake and protects HPCs from palmitate-induced stress by reorganizing the cells' morphological architecture. Furthermore, our findings suggest that MSI-1436 enhances 2-NBDG uptake by increasing the expression of SIRT1, which is associated with liver insulin sensitivity. It also promotes mitochondrial dynamics by modulating mitochondria quantity and morphotype as well as increasing the expression of PINK1, MFN1, and MFN2. Our study provides evidence that MSI-1436 has a positive impact on equine hepatic progenitor cells, indicating its potential therapeutic value in treating EMS and insulin dysregulation.
C1 [Qasem, Badr; Dabrowska, Agnieszka; Kroliczewski, Jaroslaw; Marycz, Krzysztof] Wroclaw Univ Environm & Life Sci, Fac Biol & Anim Sci, Dept Expt Biol, Norwida 27B, PL-50375 Wroclaw, Poland.
   [Lyczko, Jacek] Wroclaw Univ Environm & Life Sci, Dept Food Chem & Biocatalysis, PL-50375 Wroclaw, Poland.
   [Marycz, Krzysztof] Univ Calif Davis, Sch Vet Med, Dept Med & Epidemiol, Davis, CA 95516 USA.
C3 Wroclaw University of Environmental & Life Sciences; Wroclaw University
   of Environmental & Life Sciences; University of California System;
   University of California Davis
RP Marycz, K (corresponding author), Wroclaw Univ Environm & Life Sci, Fac Biol & Anim Sci, Dept Expt Biol, Norwida 27B, PL-50375 Wroclaw, Poland.; Marycz, K (corresponding author), Univ Calif Davis, Sch Vet Med, Dept Med & Epidemiol, Davis, CA 95516 USA.
EM badr.qasem@upwr.edu.pl; agnieszka.dabrowska@upwr.edu.pl;
   jaroslaw.kroliczewski@upwr.edu.pl; jacek.lyczko@upwr.edu.pl;
   krzysztof.marycz@upwr.edu.pl
RI Qasem, Badr/AAF-4418-2019; Łyczko, Jacek/S-5629-2019; Króliczewski,
   Jarosław/H-5930-2019; Marycz, Krzysztof/A-2249-2017
OI Qasem, Badr/0000-0001-7085-0287; Lyczko, Jacek/0000-0002-8423-7296;
   Kroliczewski, Jaroslaw/0000-0002-5895-5104
FU National Science Center
FX No Statement Available
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NR 98
TC 0
Z9 0
U1 0
U2 4
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2073-4409
J9 CELLS-BASEL
JI Cells
PD JAN
PY 2024
VL 13
IS 2
AR 152
DI 10.3390/cells13020152
PG 23
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA FW8V4
UT WOS:001148990600001
PM 38247843
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Moon, KH
   Park, SY
   Kim, YW
AF Moon, Ki Hak
   Park, So Young
   Kim, Yong Woon
TI Obesity and Erectile Dysfunction: From Bench to Clinical Implication
SO WORLD JOURNAL OF MENS HEALTH
LA English
DT Review
DE Erectile dysfunction; Metformin; Obesity; Phosphodiesterase 5 inhibitors
ID INSULIN-RESISTANCE; TNF-ALPHA; ENDOTHELIAL DYSFUNCTION; METABOLIC
   SYNDROME; NITRIC-OXIDE; LIFE-STYLE; OXIDATIVE STRESS; UP-REGULATION;
   DOUBLE-BLIND; RISK-FACTORS
AB Obesity is a major public health issue worldwide and is frequently associated with erectile dysfunction (ED). Both conditions may share an internal pathologic environment, also known as common soil. Their main pathophysiologic processes are oxidative stress, inflammation, and resultant insulin and leptin resistance. Moreover, the severity of ED is correlated with comorbid medical conditions, including obesity. Therefore, amelioration of these comorbidities may increase the efficacy of ED treatment with phosphodiesterase 5 inhibitors, the first-line medication for patients with ED. Although metformin was originally developed as an insulin sensitizer six decades ago, it has also been shown to improve leptin resistance. In addition, metformin has been reported to reduce oxidative stress, inflammatory response, and body weight, as well as improve ED, in animal and human studies. Moreover, administration of a combination of metformin and phosphodiesterase 5 inhibitors improves erectile function in patients with ED who have a poor response to sildenafil and are insulin resistant. Thus, concomitant treatment of metabolic derangements associated with obesity in patients with ED who are obese would improve the efficacy and reduce the refractory response to penile vasodilators. In this review, we discuss the connecting factors between obesity and ED and the possible combined treatment modalities.
C1 [Moon, Ki Hak] Yeungnam Univ, Coll Med, Dept Urol, Daegu, South Korea.
   [Park, So Young; Kim, Yong Woon] Yeungnam Univ, Coll Med, Dept Physiol, 170 Hyeonchung Ro, Daegu 42415, South Korea.
C3 Yeungnam University; Yeungnam University
RP Kim, YW (corresponding author), Yeungnam Univ, Coll Med, Dept Physiol, 170 Hyeonchung Ro, Daegu 42415, South Korea.
EM ywkim@med.yu.ac.kr
RI Park, So-Young/AAC-5528-2022
OI Kim, Yong Woon/0000-0003-2868-9690; Park, So-Young/0000-0002-6018-0440
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NR 89
TC 54
Z9 56
U1 0
U2 3
PU KOREAN SOC SEXUAL MEDICINE & ANDROLOGY
PI BUSAN
PA PUSAN NATL UNIV MEDICAL SCH, DEPT UROLOGY, 179 GUDEOK-RO, SEO-GU, BUSAN,
   SOUTH KOREA
SN 2287-4208
EI 2287-4690
J9 WORLD J MENS HEALTH
JI World J. Mens Health
PD MAY
PY 2019
VL 37
IS 2
BP 138
EP 147
DI 10.5534/wjmh.180026
PG 10
WC Andrology; Health Care Sciences & Services; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Health Care Sciences & Services; Urology &
   Nephrology
GA HU7PV
UT WOS:000465475300003
PM 30079640
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Üstündag, ÜV
   Ünal, I
   Cansiz, D
   Beler, M
   Kanagaraj, NK
   Kumar, AR
   Peravali, R
   Emekli-Alturfan, E
AF Ustundag, Unsal Veli
   Unal, Ismail
   Cansiz, Derya
   Beler, Merih
   Kanagaraj, Naveen Krishna
   Kumar, Amrish Rajendra
   Peravali, Ravindra
   Emekli-Alturfan, Ebru
TI 520 nm and 660 nm light-emitting diodes modulates pancreatic development
   and beta cell functions in zebrafish embryos
SO PHOTOCHEMISTRY AND PHOTOBIOLOGY
LA English
DT Article; Early Access
DE light emitting diode; pancreas; beta cell; insulin; zebrafish
ID INSULIN; MELATONIN; HOMEOSTASIS
AB Green and Red LEDs increase insulin production, but their comparative effects on pancreatic and beta cell development are unclear. Zebrafish embryos were divided into three groups: Control (n = 60), Green (G) (n = 60), and Red (R) (n = 60), then irradiated for three days (14 hours/day) with 0.5 W/cm(2) G (lambda peak = 520 nm, 180 mA) and R (lambda peak = 660 nm, 210 mA). At the end of 72 h, pancreatic and beta cells, circadian rhythm, and oxidative stress gene were analyzed using RT-PCR. Malondialdehyde, nitric oxide, superoxide dismutase, and glutathione levels were also evaluated. In the Red group, pancreatic area increased by similar to 97.13% compared to the Control group and by approximately similar to 62.16% compared to the G group (both p < 0.0001), and no significant difference in beta cell area (p = 0.964). G group insulin expression increased 2.31-fold compared to R group (p < 0.0001). Red LED treatment increased MDA levels (p < 0.001), oxidative stress (fth1b, nqo1) (p < 0.0001), and per1b during the photophase (p < 0.0001) compared to G group. R LED treatment increases oxidative stress and disrupts circadian rhythm, leading to reduced insulin secretion. The positive effects of G LED treatment have potential for metabolic syndrome, diabetes, and pancreatic diseases.
C1 [Ustundag, Unsal Veli] Istanbul Atlas Univ, Fac Med, Dept Med Biochem, Istanbul, Turkiye.
   [Ustundag, Unsal Veli] Marmara Univ, Inst Hlth Sci, Dept Biochem, Istanbul, Turkiye.
   [Unal, Ismail; Cansiz, Derya] Istanbul Medipol Univ, Fac Med, Dept Med Biochem, Istanbul, Turkiye.
   [Beler, Merih; Emekli-Alturfan, Ebru] Marmara Univ, Fac Dent, Dept Basic Med Sci, Istanbul, Turkiye.
   [Kanagaraj, Naveen Krishna; Kumar, Amrish Rajendra; Peravali, Ravindra] Karlsruhe Inst Technol, Inst Biol & Chem Syst, Karlsruhe, Germany.
C3 Istanbul Atlas University; Marmara University; Istanbul Medipol
   University; Marmara University; Helmholtz Association; Karlsruhe
   Institute of Technology
RP Üstündag, ÜV (corresponding author), Istanbul Atlas Univ, Fac Med, Dept Med Biochem, Istanbul, Turkiye.
EM uvustundag@yahoo.com
RI Ünal, İsmail/GPG-1965-2022; CANSIZ, Derya/ABF-7508-2020;
   Emekli-Alturfan, Ebru/X-2758-2019
OI Cansiz, Derya/0000-0002-6274-801X
FU Scientific and Technological Research Council of Turkiye (TUBIdot;TAK)
   2214A Program; Scientific Research Projects Foundation (BAP) of the
   Marmara University [TDK-2021-10172]
FX Scientific and Technological Research Council of Turkiye (TUB &
   Idot;TAK) 2214A Program; Scientific Research Projects Foundation (BAP)
   of the Marmara University, Grant/Award Number: TDK-2021-10172.
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NR 58
TC 0
Z9 0
U1 4
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0031-8655
EI 1751-1097
J9 PHOTOCHEM PHOTOBIOL
JI Photochem. Photobiol.
PD 2024 DEC 10
PY 2024
DI 10.1111/php.14050
EA DEC 2024
PG 16
WC Biochemistry & Molecular Biology; Biophysics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics
GA P1B8R
UT WOS:001375361100001
PM 39655413
DA 2025-06-11
ER

PT J
AU Cox, FF
   Misiou, A
   Vierkant, A
   Ale-Agha, N
   Grandoch, M
   Haendeler, J
   Altschmied, J
AF Cox, Fiona Frederike
   Misiou, Angelina
   Vierkant, Annika
   Ale-Agha, Niloofar
   Grandoch, Maria
   Haendeler, Judith
   Altschmied, Joachim
TI Protective Effects of Curcumin in Cardiovascular Diseases-Impact on
   Oxidative Stress and Mitochondria
SO CELLS
LA English
DT Review
DE aging; atherosclerosis; cardiovascular diseases; curcumin; mitochondria;
   myocardial infarction; obesity; oxidative stress; risk factors
ID BROWN ADIPOSE-TISSUE; ISCHEMIA-REPERFUSION INJURY; SMOOTH-MUSCLE-CELLS;
   NITRIC-OXIDE; METABOLIC SYNDROME; SUBCLINICAL ATHEROSCLEROSIS;
   ANTIOXIDANT CAPACITY; ENDOTHELIAL FUNCTION; CALORIE RESTRICTION;
   ATHEROGENIC RISK
AB Cardiovascular diseases (CVDs) contribute to a large part of worldwide mortality. Similarly, two of the major risk factors for these diseases, aging and obesity, are also global problems. Aging, the gradual decline of body functions, is non-modifiable. Obesity, a modifiable risk factor for CVDs, also predisposes to type 2 diabetes mellitus (T2DM). Moreover, it affects not only the vasculature and the heart but also specific fat depots, which themselves have a major impact on the development and progression of CVDs. Common denominators of aging, obesity, and T2DM include oxidative stress, mitochondrial dysfunction, metabolic abnormalities such as altered lipid profiles and glucose metabolism, and inflammation. Several plant substances such as curcumin, the major active compound in turmeric root, have been used for a long time in traditional medicine and for the treatment of CVDs. Newer mechanistic, animal, and human studies provide evidence that curcumin has pleiotropic effects and attenuates numerous parameters which contribute to an increased risk for CVDs in aging as well as in obesity. Thus, curcumin as a nutraceutical could hold promise in the prevention of CVDs, but more standardized clinical trials are required to fully unravel its potential.
C1 [Cox, Fiona Frederike; Misiou, Angelina; Vierkant, Annika; Ale-Agha, Niloofar; Haendeler, Judith; Altschmied, Joachim] Univ Hosp, Fac Med, Environm Induced Cardiovasc Degenerat, Clin Chem & Lab Diagnost, D-40225 Dusseldorf, Germany.
   [Cox, Fiona Frederike; Misiou, Angelina; Vierkant, Annika; Ale-Agha, Niloofar; Grandoch, Maria; Haendeler, Judith; Altschmied, Joachim] Heinrich Heine Univ, D-40225 Dusseldorf, Germany.
   [Cox, Fiona Frederike; Misiou, Angelina; Grandoch, Maria] Univ Hosp, Inst Pharmacol & Clin Pharmacol, Fac Med, D-40225 Dusseldorf, Germany.
   [Altschmied, Joachim] IUF Leibniz Res Inst Environm Med, D-40225 Dusseldorf, Germany.
C3 Heinrich Heine University Dusseldorf; Leibniz Association; Leibniz
   Institut fur Umweltmedizinische Forschung (IUF)
RP Haendeler, J; Altschmied, J (corresponding author), Univ Hosp, Fac Med, Environm Induced Cardiovasc Degenerat, Clin Chem & Lab Diagnost, D-40225 Dusseldorf, Germany.; Haendeler, J; Altschmied, J (corresponding author), Heinrich Heine Univ, D-40225 Dusseldorf, Germany.; Altschmied, J (corresponding author), IUF Leibniz Res Inst Environm Med, D-40225 Dusseldorf, Germany.
EM fiona.cox@hhu.de; misiou@uni-duesseldorf.de; annika.vierkant@hhu.de;
   aleagha@hhu.de; maria.grandoch@hhu.de; juhae001@hhu.de; joalt001@hhu.de
RI Haendeler, Judith/ISS-3378-2023
OI Misiou, Angelina/0000-0003-0239-3744; Haendeler,
   Judith/0000-0001-8507-4540
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NR 199
TC 82
Z9 86
U1 2
U2 52
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2073-4409
J9 CELLS-BASEL
JI Cells
PD FEB
PY 2022
VL 11
IS 3
AR 342
DI 10.3390/cells11030342
PG 24
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA ZG2AX
UT WOS:000760064900001
PM 35159155
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Abd El-Ghffar, EA
   Barakat, A
   Shehata, SM
AF Abd El-Ghffar, Eman A.
   Barakat, Alaa
   Shehata, Safa Mohamed
TI Influence of vitamin C or/and L-methionine on hyperglycaemia,
   hyperlipidaemia and hematological alterations in alloxan-induced
   diabetes in rats
SO PROGRESS IN NUTRITION
LA English
DT Article
DE Antioxidant; L-methionine; oxidative stress; partial thromboplastin
   time; prothrombin time; vitamin C
ID ADENOSYL-L-METHIONINE; INDUCED OXIDATIVE STRESS; LIPID-PEROXIDATION;
   ASCORBIC-ACID; ANTIOXIDANT DEFENSE; SULFOXIDE REDUCTASE;
   ALPHA-TOCOPHEROL; LIPOIC-ACID; RESIDUES; SUPPLEMENTATION
AB Background: Here, we assessed the possible therapeutic potential of vitamin C or/and L-methionine on some biochemical and hematological alterations in alloxan-induced diabetes in rats. Diabetes was induced by single intraperitoneal (100 mg/kg b.w, i.p) dose of alloxan monohydrate solution. The animals were randomly grouped into five as follows: the normal control group, diabetic control group, diabetic treated with vitamin C (Vit C) group, diabetic treated with L-methionine (L-Meth) group, diabetic treated with Vit C and L-Meth group. The regimens were given once daily for four weeks. Significant disturbances in glucose, glycated hemoglobin, lipid profiles, prothrombin time (PT), partial thromboplastin time (PTT), some hematological and oxidant/antioxidant parameters was observed in diabetic control rats. Only the combination of Vit C and L-Meth had the most beneficial effect on hyperglycemia, dyslipidemia, abnormal coagulation indices and oxidative stress in alloxan-induced diabetes in rats. From the present data, we concluded that Vit C and L-Meth in combination may have therapeutic effects against the risks of the metabolic syndrome and coronary artery diseases and could improve the health of rats with diabetes mellitus.
C1 [Abd El-Ghffar, Eman A.] Ain Shams Univ, Fac Sci, Zool Dept, Khalifa El Maamon St, Cairo 11566, Egypt.
   [Barakat, Alaa] Heliopolis Univ, Fac Pharm, Dept Biochem & Biotechnol, Cairo, Egypt.
   [Shehata, Safa Mohamed] Ain Shams Univ Hosp, Clin Pathol Dept, Cairo, Egypt.
C3 Egyptian Knowledge Bank (EKB); Ain Shams University; Egyptian Knowledge
   Bank (EKB); Heliopolis University; Egyptian Knowledge Bank (EKB); Ain
   Shams University
RP Abd El-Ghffar, EA (corresponding author), Ain Shams Univ, Fac Sci, Zool Dept, Khalifa El Maamon St, Cairo 11566, Egypt.
EM eman_a@sci.asu.edu.eg
RI Abdelghffar, Eman/ADX-3593-2022
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NR 65
TC 4
Z9 4
U1 0
U2 5
PU MATTIOLI 1885
PI FIDENZA
PA VIA DELLA LODESANA 649-SX, FIDENZA, 43046 PR, ITALY
SN 1129-8723
J9 PROG NUTR
JI Prog. Nutr.
PD DEC
PY 2018
VL 20
SU 2
BP 270
EP 278
DI 10.23751/pn.v20i2-S.5418
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA HY0RW
UT WOS:000467821100032
DA 2025-06-11
ER

PT J
AU Choi, UK
   Lee, OH
   Yim, JH
   Cho, CW
   Rhee, YK
   Lim, SI
   Kim, YC
AF Choi, Ung-Kyu
   Lee, Ok-Hwan
   Yim, Joo Hyuk
   Cho, Chang-Won
   Rhee, Young Kyung
   Lim, Seong-Il
   Kim, Young-Chan
TI Hypolipidemic and Antioxidant Effects of Dandelion (Taraxacum
   officinale) Root and Leaf on Cholesterol-Fed Rabbits
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE dandelion; Taraxacum officinale; atherosclerosis; antioxidant activity;
   hypolipidemic effects
ID HYPERCHOLESTEROLEMIC ATHEROSCLEROSIS; INSULIN-RESISTANCE; IN-VIVO;
   GLUTATHIONE; LIVER; FLAVONOIDS; TISSUES
AB Dandelion (Taraxacum officinale), an oriental herbal medicine, has been shown to favorably affect choleretic, antirheumatic and diuretin properties. Recent reports have indicated that excessive oxidative stress contributes to the development of atherosclerosis-linked metabolic syndrome. The objective of this current study was to investigate the possible hypolipidemic and antioxidative effects of dandelion root and leaf in rabbits fed with a high-cholesterol diet. A group of twenty eight male rabbits was divided into four subgroups; a normal diet group, a high-cholesterol diet group, a high-cholesterol diet with 1% (w/w) dandelion leaf group, and a high-cholesterol diet with 1% (w/w) dandelion root group. After the treatment period, the plasma antioxidant enzymes and lipid profiles were determined. Our results show that treatment with dandelion root and leaf positively changed plasma antioxidant enzyme activities and lipid profiles in cholesterol-fed rabbits, and thus may have potential hypolipidemic and antioxidant effects. Dandelion root and leaf could protect against oxidative stress linked atherosclerosis and decrease the atherogenic index.
C1 [Yim, Joo Hyuk; Cho, Chang-Won; Rhee, Young Kyung; Lim, Seong-Il; Kim, Young-Chan] Korea Food Res Inst, Songnam 463746, Kyonggi, South Korea.
   [Choi, Ung-Kyu] Pohang Ctr Evaluat Biomat, Pohang 790834, South Korea.
   [Lee, Ok-Hwan] CHA Univ, Dept Biomed Sci, Songnam 463836, Kyonggi, South Korea.
C3 Korea Food Research Institute (KFRI); Pochon Cha University
RP Kim, YC (corresponding author), Korea Food Res Inst, Songnam 463746, Kyonggi, South Korea.
EM cuk8272@hanmail.net; loh99@hanmail.net; jlunar@naver.com;
   cwcho@kfri.re.kr; ykrhee@kfri.re.kr; silim@kfri.re.kr; yckim@kfri.re.kr
RI Cho, Chang-Won/GPF-4456-2022; Lee, Ho-jeong/S-4934-2019
OI Lee, Ok-Hwan/0000-0001-6855-3136
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NR 29
TC 98
Z9 108
U1 6
U2 54
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD JAN
PY 2010
VL 11
IS 1
BP 67
EP 78
DI 10.3390/ijms11010067
PG 12
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 548WN
UT WOS:000274000500005
PM 20162002
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Wu, HL
   Liu, QZ
   Kalavagunta, PK
   Huang, QL
   Lv, WT
   An, XH
   Chen, HJ
   Wang, T
   Heriniaina, RM
   Qiao, T
   Shang, J
AF Wu, Huali
   Liu, Qiongzhen
   Kalavagunta, Praveen Kumar
   Huang, Qiaoling
   Lv, Wenting
   An, Xiaohong
   Chen, Haijuan
   Wang, Tao
   Heriniaina, Rakotomalala Manda
   Qiao, Tong
   Shang, Jing
TI Normal diet Vs High fat diet - A comparative study: Behavioral
   and neuroimmunological changes in adolescent male mice.
SO METABOLIC BRAIN DISEASE
LA English
DT Article
DE High-fat diet (HFD); Adolescent mice; Obesity; Behavioral changes;
   Glucose intolerance; Hippocampal inflammation
ID HIPPOCAMPAL NEUROGENESIS; DENDRITIC GROWTH; DENTATE GYRUS; METABOLIC
   SYNDROME; CHILDHOOD OBESITY; MESSENGER-RNA; IMMUNE-SYSTEM; DEPRESSION;
   MEMORY; BDNF
AB Recent evidence has established that consumption of High-fat diet (HFD)-induced obesity is associated with deficits in hippocampus-dependent memory/learning and mood states. Nevertheless the link between obesity and emotional disorders still remains to be elucidated. This issue is of particular interest during adolescence, which is important period for shaping learning/memory and mood regulation that can be sensitive to the detrimental effects of HFD. Our present study is focused to investigate behavioral and metabolic influences of short-term HFD intake in adolescent C57BL/6 mice. HFD caused weight gain, impaired glucose tolerance (IGT) and depression-like behavior as early as after 3 weeks which was clearly proved by a decrease in number of groomings in the open field test (OFT) and an increase in immobility time in the tail suspension test (TST). In the 4th week HFD induced obese model was fully developed and above behavioral symptoms were more dominant (decrease in number of crossings and groomings and increase in immobility time in both FST and TST). At the end of 6th week hippocampal analysis revealed the differences in morphology (reduced Nissl positive neurons and decreased the 5-HT1A receptor expression), neuronal survival (increased cleaved caspase-3 expression), synaptic plasticity (down regulation of p-CREB and BDNF), and inflammatory responses (increase in expression of pro-inflammatory cytokines and decrease in expression of anti-inflammatory cyokines) in HFD mice. Our results demonstrate that, high-fat feeding of adolescent mice could provoke "depression-like" behavior as early as 3 weeks and modulate structure, neuron survival and neuroinflammation in hippocampus as early as 6 weeks proving that adolescent age is much prone to adverse effects of HFD, which causes obesity, behavioral differences, memory and learning deficiencies.
C1 [Wu, Huali; Liu, Qiongzhen; Kalavagunta, Praveen Kumar; Huang, Qiaoling; Lv, Wenting; An, Xiaohong; Chen, Haijuan; Wang, Tao; Heriniaina, Rakotomalala Manda; Shang, Jing] China Pharmaceut Univ, State Key Lab Nat Med, Nanjing 210009, Jiangsu, Peoples R China.
   [Wu, Huali] China Pharmaceut Univ, Dept Pharmacol, Nanjing 210009, Jiangsu, Peoples R China.
   [Liu, Qiongzhen; Kalavagunta, Praveen Kumar; Huang, Qiaoling; Lv, Wenting; An, Xiaohong; Wang, Tao; Heriniaina, Rakotomalala Manda; Shang, Jing] China Pharmaceut Univ, Jiangsu Key Lab TCM Evaluat & Translat Res, Nanjing 211198, Jiangsu, Peoples R China.
   [Kalavagunta, Praveen Kumar; Huang, Qiaoling; Lv, Wenting; An, Xiaohong; Wang, Tao; Heriniaina, Rakotomalala Manda; Shang, Jing] China Pharmaceut Univ, Sch Tradit Chinese Pharm, Nanjing 211198, Jiangsu, Peoples R China.
   [Chen, Haijuan; Shang, Jing] Chinese Acad Sci, Northwest Inst Plateau Biol, Qinghai Key Lab Tibetan Med Pharmacol & Safety Ev, Xining 810008, Qinghai, Peoples R China.
   [Qiao, Tong] Nanjing Drum Tower Hosp, Dept Vasc Surg, Nanjing 210008, Jiangsu, Peoples R China.
C3 China Pharmaceutical University; China Pharmaceutical University; China
   Pharmaceutical University; China Pharmaceutical University; Chinese
   Academy of Sciences; Nanjing University
RP Shang, J (corresponding author), China Pharmaceut Univ, State Key Lab Nat Med, Nanjing 210009, Jiangsu, Peoples R China.; Shang, J (corresponding author), China Pharmaceut Univ, Jiangsu Key Lab TCM Evaluat & Translat Res, Nanjing 211198, Jiangsu, Peoples R China.; Shang, J (corresponding author), China Pharmaceut Univ, Sch Tradit Chinese Pharm, Nanjing 211198, Jiangsu, Peoples R China.; Shang, J (corresponding author), Chinese Acad Sci, Northwest Inst Plateau Biol, Qinghai Key Lab Tibetan Med Pharmacol & Safety Ev, Xining 810008, Qinghai, Peoples R China.; Qiao, T (corresponding author), Nanjing Drum Tower Hosp, Dept Vasc Surg, Nanjing 210008, Jiangsu, Peoples R China.
EM qiaotongmail@aliyun.com; shangjing21cn@163.com
RI Wang, Tao/KUD-2403-2024; MANDA HERINIAINA, RAKOTOMALALA/ITT-3677-2023;
   Qiao, Tong/IYJ-6269-2023
OI Kalavagunta, Praveen Kumar/0000-0001-8991-8069
FU One Hundred Person Project of The Chinese Academy of Sciences; Applied
   Basic Research Programs of Qinghai Province [Y229461211]; Science and
   Technology Plan Projects in Xinjiang [2014AB043]; CMA-L'OREAL China
   Skin/Hair Grant [S2017140917]; Prospective Joint Research Project of
   Jiangsu Province [BY2016078-02]; National Natural Science Foundation of
   China [81603216]; Science and Technology Plan Projects in Qinghai
   Province [2015-ZJ-733]
FX This study was supported by One Hundred Person Project of The Chinese
   Academy of Sciences, Applied Basic Research Programs of Qinghai Province
   (Y229461211); Science and Technology Plan Projects in Xinjiang
   (2014AB043); 2017 CMA-L'OREAL China Skin/Hair Grant (No. S2017140917);
   Prospective Joint Research Project of Jiangsu Province (BY2016078-02);
   The National Natural Science Foundation of China (No. 81603216) and
   Science and Technology Plan Projects in Qinghai Province (2015-ZJ-733).
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NR 62
TC 58
Z9 64
U1 3
U2 43
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0885-7490
EI 1573-7365
J9 METAB BRAIN DIS
JI Metab. Brain Dis.
PD FEB
PY 2018
VL 33
IS 1
BP 177
EP 190
DI 10.1007/s11011-017-0140-z
PG 14
WC Endocrinology & Metabolism; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology
GA FS8JU
UT WOS:000422658000019
PM 29101600
DA 2025-06-11
ER

PT J
AU Liu, MH
   Chen, RM
   Zheng, ZW
   Xu, SL
   Hou, CY
   Ding, YN
   Zhang, ML
   Bao, MH
   He, BS
   Li, S
AF Liu, Menghua
   Chen, Rumeng
   Zheng, Zhiwei
   Xu, Shuling
   Hou, Chunyan
   Ding, Yining
   Zhang, Mengling
   Bao, Meihua
   He, Binsheng
   Li, Sen
TI Mechanisms of inflammatory microenvironment formation in cardiometabolic
   diseases: molecular and cellular perspectives
SO FRONTIERS IN CARDIOVASCULAR MEDICINE
LA English
DT Review
DE cardiometabolic diseases; inflammatory microenvironment;
   atherosclerosis; hypertension; diabetic cardiomyopathy
ID MUSCLE INSULIN-RESISTANCE; OXIDATIVE STRESS; ENDOTHELIAL DYSFUNCTION;
   METABOLIC SYNDROME; T-CELLS; ATHEROSCLEROSIS; HYPERTENSION; ADHESION;
   ACTIVATION; DISORDERS
AB Cardiometabolic diseases (CMD) are leading causes of death and disability worldwide, with complex pathophysiological mechanisms in which inflammation plays a crucial role. This review aims to elucidate the molecular and cellular mechanisms within the inflammatory microenvironment of atherosclerosis, hypertension and diabetic cardiomyopathy. In atherosclerosis, oxidized low-density lipoprotein (ox-LDL) and pro-inflammatory cytokines such as Interleukin-6 (IL-6) and Tumor Necrosis Factor-alpha (TNF-alpha) activate immune cells contributing to foam cell formation and arterial wall thickening. Hypertension involves the activation of the renin-angiotensin system (RAS) alongside oxidative stress-induced endothelial dysfunction and local inflammation mediated by T cells. In diabetic cardiomyopathy, a high-glucose environment leads to the accumulation of advanced glycation end products (AGEs), activating the Receptor for Advanced Glycation Endproducts (RAGE) and triggering inflammatory responses that further damage cardiac and microvascular function. In summary, the inflammatory mechanisms in different types of metabolic cardiovascular diseases are complex and diverse; understanding these mechanisms deeply will aid in developing more effective individualized treatment strategies.
C1 [Liu, Menghua; Chen, Rumeng; Zheng, Zhiwei; Xu, Shuling; Hou, Chunyan; Ding, Yining; Li, Sen] Beijing Univ Chinese Med, Sch Life Sci, Beijing, Peoples R China.
   [Zhang, Mengling] Changsha Med Univ, Sch Stomatol, Changsha, Peoples R China.
   [Bao, Meihua; He, Binsheng] Changsha Med Univ, Sch Pharmaceut Sci, Hunan Key Lab Res & Dev Novel Pharmaceut Preparat, Changsha, Peoples R China.
C3 Beijing University of Chinese Medicine; Changsha Medical University;
   Changsha Medical University
RP Li, S (corresponding author), Beijing Univ Chinese Med, Sch Life Sci, Beijing, Peoples R China.; Bao, MH; He, BS (corresponding author), Changsha Med Univ, Sch Pharmaceut Sci, Hunan Key Lab Res & Dev Novel Pharmaceut Preparat, Changsha, Peoples R China.
EM mhbao78@163.com; hbscsmu@163.com; senli@bucm.edu.cn
RI zheng, zhiwei/KCJ-9060-2024; Chen, Rumeng/JCN-8712-2023; Qu,
   Jia/HGA-2057-2022; Xu, Shuling/JPK-2983-2023
FU National Natural Science Foundation of China [81973698, 81703942]; BUCM
   Precision Cultivation Program [JZPY-202205]; BUCM Research Development
   Fund [2024-JYB-900203-009]; Key Research Projects of Hunan Provincial
   Department of Education [23A0662]
FX The author(s) declare financial support was received for the research,
   authorship, and/or publication of this article. This study was supported
   by the National Natural Science Foundation of China (Grant No. 81973698
   and 81703942), the BUCM Precision Cultivation Program (Grant No.
   JZPY-202205), the BUCM Research Development Fund (Grant No.
   2024-JYB-900203-009),and the Key Research Projects of Hunan Provincial
   Department of Education (Grant No. 23A0662).
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NR 132
TC 3
Z9 3
U1 5
U2 5
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2297-055X
J9 FRONT CARDIOVASC MED
JI Front. Cardiovasc. Med.
PD JAN 14
PY 2025
VL 11
AR 1529903
DI 10.3389/fcvm.2024.1529903
PG 10
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA T7L5G
UT WOS:001406774900001
PM 39877020
OA gold
DA 2025-06-11
ER

PT J
AU Parasiliti-Caprino, M
   Bollati, M
   Merlo, FD
   Ghigo, E
   Maccario, M
   Bo, S
AF Parasiliti-Caprino, Mirko
   Bollati, Martina
   Merlo, Fabio Dario
   Ghigo, Ezio
   Maccario, Mauro
   Bo, Simona
TI Adipose Tissue Dysfunction in Obesity: Role of Mineralocorticoid
   Receptor
SO NUTRIENTS
LA English
DT Review
DE mineralocorticoid receptor; obesity; insulin resistance; metabolic
   syndrome; adipose tissue dysfunction; oxidative stress; inflammation
ID METABOLIC RISK-FACTORS; C-REACTIVE PROTEIN; BODY-MASS INDEX;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; MITOCHONDRIAL DYSFUNCTION; PRIMARY
   ALDOSTERONISM; PRIMARY HYPERALDOSTERONISM; ADIPOCYTE DYSFUNCTION;
   DIABETES-MELLITUS
AB The mineralocorticoid receptor (MR) acts as an essential regulator of blood pressure, volume status, and electrolyte balance. However, in recent decades, a growing body of evidence has suggested that MR may also have a role in mediating pro-inflammatory, pro-oxidative, and pro-fibrotic changes in several target organs, including the adipose tissue. The finding that MR is overexpressed in the adipose tissue of patients with obesity has led to the hypothesis that this receptor can contribute to adipokine dysregulation and low-grade chronic inflammation, alterations that are linked to the development of obesity-related metabolic and cardiovascular complications. Moreover, several studies in animal models have investigated the role of MR antagonists (MRAs) in preventing the metabolic alterations observed in obesity. In the present review we will focus on the potential mechanisms by which MR activation can contribute to adipose tissue dysfunction in obesity and on the possible beneficial effects of MRAs in this setting.
C1 [Parasiliti-Caprino, Mirko; Bollati, Martina; Ghigo, Ezio; Maccario, Mauro] Univ Turin, Dept Med Sci, Endocrinol Diabet & Metab, I-10126 Turin, Italy.
   [Merlo, Fabio Dario] Citta Salute & Sci Hosp, Dietet & Clin Nutr Unit, I-10126 Turin, Italy.
   [Ghigo, Ezio; Maccario, Mauro; Bo, Simona] Univ Turin, Dept Med Sci, I-10126 Turin, Italy.
C3 University of Turin; A.O.U. Citta della Salute e della Scienza di
   Torino; University of Turin
RP Parasiliti-Caprino, M (corresponding author), Univ Turin, Dept Med Sci, Endocrinol Diabet & Metab, I-10126 Turin, Italy.
EM mirko.parasiliticaprino@unito.it
RI Parasiliti-Caprino, Mirko/ABB-2735-2020; Bo, Simona/AAC-1110-2019
OI Parasiliti-Caprino, Mirko/0000-0002-6930-7073; Merlo, Fabio
   Dario/0000-0002-8513-335X; Bo, Simona/0000-0001-6862-8628
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NR 101
TC 8
Z9 8
U1 0
U2 5
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD NOV
PY 2022
VL 14
IS 22
AR 4735
DI 10.3390/nu14224735
PG 16
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 6K7SV
UT WOS:000887697800001
PM 36432422
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Tsaousidou, E
   Paeger, L
   Belgardt, BF
   Pal, M
   Wunderlich, CM
   Brönneke, H
   Collienne, U
   Hampel, B
   Wunderlich, FT
   Schmidt-Supprian, M
   Kloppenburg, P
   Brüning, JC
AF Tsaousidou, Eva
   Paeger, Lars
   Belgardt, Bengt F.
   Pal, Martin
   Wunderlich, Claudia M.
   Broenneke, Hella
   Collienne, Ursel
   Hampel, Brigitte
   Wunderlich, F. Thomas
   Schmidt-Supprian, Marc
   Kloppenburg, Peter
   Bruening, Jens C.
TI Distinct Roles for JNK and IKK Activation in Agouti-Related Peptide
   Neurons in the Development of Obesity and Insulin Resistance
SO CELL REPORTS
LA English
DT Article
ID ENDOPLASMIC-RETICULUM STRESS; AMPA RECEPTOR PHOSPHORYLATION;
   DIET-INDUCED OBESITY; N-TERMINAL KINASE; BETA/NF-KAPPA-B; LEPTIN
   RESISTANCE; GLUCOSE-HOMEOSTASIS; ENERGY HOMEOSTASIS; EXPRESSING NEURONS;
   ER STRESS
AB Activation of c-Jun N-terminal kinase 1 (JNK1)- and inhibitor of nuclear factor kappa-B kinase 2 (IKK2)-dependent signaling plays a crucial role in the development of obesity-associated insulin and leptin resistance not only in peripheral tissues but also in the CNS. Here, we demonstrate that constitutive JNK activation in agouti-related peptide (AgRP)-expressing neurons of the hypothalamus is sufficient to induce weight gain and adiposity in mice as a consequence of hyperphagia. JNK activation increases spontaneous action potential firing of AgRP cells and causes both neuronal and systemic leptin resistance. Similarly, activation of IKK2 signaling in AgRP neurons also increases firing of these cells but fails to cause obesity and leptin resistance. In contrast to JNK activation, IKK2 activation blunts insulin signaling in AgRP neurons and impairs systemic glucose homeostasis. Collectively, these experiments reveal both overlapping and nonredundant effects of JNK- and IKK-dependent signaling in AgRP neurons, which cooperate in the manifestation of the metabolic syndrome.
C1 [Tsaousidou, Eva; Belgardt, Bengt F.; Wunderlich, Claudia M.; Hampel, Brigitte; Wunderlich, F. Thomas; Bruening, Jens C.] Inst Genet, Dept Mouse Genet & Metab, D-50674 Cologne, Germany.
   [Tsaousidou, Eva; Paeger, Lars; Wunderlich, Claudia M.; Collienne, Ursel; Hampel, Brigitte; Wunderlich, F. Thomas; Kloppenburg, Peter; Bruening, Jens C.] Cologne Excellence Cluster Cellular Stress Respon, D-50931 Cologne, Germany.
   [Tsaousidou, Eva; Wunderlich, Claudia M.; Hampel, Brigitte; Wunderlich, F. Thomas; Bruening, Jens C.] Univ Cologne, Ctr Mol Med CMMC, D-50931 Cologne, Germany.
   [Tsaousidou, Eva; Wunderlich, Claudia M.; Hampel, Brigitte; Wunderlich, F. Thomas; Bruening, Jens C.] Univ Hosp Cologne, Ctr Endocrinol Diabet & Prevent Med CEDP, D-50937 Cologne, Germany.
   [Tsaousidou, Eva; Wunderlich, Claudia M.; Hampel, Brigitte; Wunderlich, F. Thomas; Bruening, Jens C.] Max Planck Inst Metab Res, D-50931 Cologne, Germany.
   [Paeger, Lars; Collienne, Ursel; Kloppenburg, Peter] Univ Cologne, Inst Zool, D-50674 Cologne, Germany.
   [Pal, Martin] Baker IDI Heart & Diabet Inst, Cellular & Mol Metab Lab, Melbourne, Vic 3004, Australia.
   [Broenneke, Hella] Cologne Excellence Cluster Cellular Stress Respon, Mouse Phenotyping Core Facil, Cologne, Germany.
   [Schmidt-Supprian, Marc] Tech Univ Munich, Dept Hematol & Oncol, Klinikum Rechts Isar, D-81675 Munich, Germany.
C3 University of Cologne; University of Cologne; University of Cologne;
   University of Cologne; University of Cologne; Baker Heart and Diabetes
   Institute; University of Cologne; Technical University of Munich
RP Brüning, JC (corresponding author), Inst Genet, Dept Mouse Genet & Metab, D-50674 Cologne, Germany.
EM bruening@sf.mpg.de
RI Schmidt-Supprian, Marc/F-5893-2011; Pal, Martin/AAL-8685-2020;
   Tsaousidou, Eva/L-7602-2017
OI Belgardt, Bengt-Frederik/0000-0003-4537-9002; Tsaousidou,
   Eva/0000-0003-2751-1911; Pal, Martin/0000-0002-1563-5426; Paeger,
   Lars/0000-0001-8716-3483
FU DFG [BR 1492/7-1]; IGSDHD; Cologne Graduate School of Ageing Research;
   DFG within the Excellence Initiative by German Federal and State
   Governments (CECAD); European Community's 7th Framework Programme (FP7)
   [201608]; Helmholtz Alliance Imaging and Curing Environmental Metabolic
   Diseases (ICEMED) through the Initiative and Networking Fund of the
   Helmholtz Association
FX We are grateful to G. Schmall and T. Rayle for excellent secretarial
   assistance and Jens Alber and Helmut Wratil for outstanding technical
   assistance. We thank Joel Elmquist and Brad B. Lowell for the
   AgRP<SUP>Cre</SUP> mice used in this study. We are grateful to Jiahuai
   Han and Anning Lin for plasmids containing MKK7D and JNKK2-JNK1,
   respectively. We are grateful to Dr. A. F. Parlow and the National
   Hormone and Peptide Program (NHPP) for the recombinant mouse leptin. The
   images of the graphical abstract were adapted from Servier Medical Art.
   M.S.-S. received support from the DFG through an Emmy Noether Programme.
   E.T. received support from the IGSDHD. U.C. received support from the
   Cologne Graduate School of Ageing Research. This work was supported by a
   grant from the DFG (BR 1492/7-1) to J.C.B. and was funded by the DFG
   within the Excellence Initiative by German Federal and State Governments
   (CECAD), and the research leading to these results has received funding
   from the European Community's 7th Framework Programme (FP7/2007-2013)
   under grant agreement no. 201608 (TOBI). This work was funded (in part)
   by the Helmholtz Alliance Imaging and Curing Environmental Metabolic
   Diseases (ICEMED) through the Initiative and Networking Fund of the
   Helmholtz Association.
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NR 64
TC 91
Z9 102
U1 0
U2 13
PU CELL PRESS
PI CAMBRIDGE
PA 50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA
SN 2211-1247
J9 CELL REP
JI Cell Reports
PD NOV 20
PY 2014
VL 9
IS 4
BP 1495
EP 1506
DI 10.1016/j.celrep.2014.10.045
PG 12
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA AU3QW
UT WOS:000345529600029
PM 25456138
OA gold
DA 2025-06-11
ER

PT J
AU Bilhartz, TD
   Bilhartz, PA
   Bilhartz, TN
   Bilhartz, RD
AF Bilhartz, Terry D.
   Bilhartz, Patty A.
   Bilhartz, Teri N.
   Bilhartz, Rocky D.
TI Making Use of a Natural Stress Test: Pregnancy and Cardiovascular Risk
SO JOURNAL OF WOMENS HEALTH
LA English
DT Article
ID ISCHEMIC-HEART-DISEASE; CORONARY-ARTERY-DISEASE; LONG-TERM MORTALITY;
   HYPERTENSIVE DISORDERS; GESTATIONAL-AGE; METABOLIC SYNDROME; LATER LIFE;
   PREECLAMPSIA; WOMEN; MORBIDITY
AB The gestational period serves as a natural stress test that can be used to predict future cardiovascular health risks of female patients. Recent evidence confirms that mothers with hypertensive pregnancies have higher cardiovascular disease (CVD) risks compared to other women of similar age. In women with preeclampsia, those delivering before 37 weeks of gestation and mothers with recurring preeclampsia in subsequent pregnancies carry the greater risks. These sex-specific risks are of similar magnitude to traditional CVD risk factors, such as smoking and obesity. Unfortunately, none of the commonly used CVD risk stratification models make use of these sex-specific markers, which can powerfully predict future CVD outcomes. Because women have historically posed a greater diagnostic challenge than men in assessing CVD risks, better models for risk stratification in this sex group are needed. A history of hypertension in pregnancy should be included as a variable in cardiovascular risk stratification. In addition, screening women for a history of preeclampsia should become routine practice, with greater emphasis placed on therapies to modify adverse outcomes for these higher-risk women.
C1 [Bilhartz, Terry D.] Sam Houston State Univ, Coll Humanities & Social Sci, Huntsville, TX 77341 USA.
   [Bilhartz, Patty A.; Bilhartz, Rocky D.] Scott & White Mem Hosp & Clin, Texas A&M Hlth Sci Ctr, Temple, TX 76508 USA.
   [Bilhartz, Teri N.] Stony Brook Hlth Sci Sch Med, Dept Prevent Med, Stony Brook, NY USA.
C3 Texas State University System; Sam Houston State University; Texas A&M
   University System; Texas A&M University College Station; Texas A&M
   Health Science Center; Scott & White Medical Center
RP Bilhartz, TD (corresponding author), Sam Houston State Univ, Coll Humanities & Social Sci, Box 2509, Huntsville, TX 77341 USA.
EM his_tdb@shsu.edu
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NR 65
TC 19
Z9 25
U1 0
U2 6
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-9996
EI 1931-843X
J9 J WOMENS HEALTH
JI J. Womens Health
PD MAY
PY 2011
VL 20
IS 5
BP 695
EP 701
DI 10.1089/jwh.2010.2291
PG 7
WC Public, Environmental & Occupational Health; Medicine, General &
   Internal; Obstetrics & Gynecology; Women's Studies
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; General & Internal
   Medicine; Obstetrics & Gynecology; Women's Studies
GA 766MF
UT WOS:000290785800008
PM 21453034
DA 2025-06-11
ER

PT J
AU Rahelic, V
   Perkovic, T
   Romic, L
   Perkovic, P
   Klobucar, S
   Pavic, E
   Rahelic, D
AF Rahelic, Valentina
   Perkovic, Tomislav
   Romic, Lucija
   Perkovic, Pavo
   Klobucar, Sanja
   Pavic, Eva
   Rahelic, Dario
TI The Role of Behavioral Factors on Chronic Diseases-Practice and
   Knowledge Gaps
SO HEALTHCARE
LA English
DT Review
DE lifestyle medicine; chronic diseases; public health interventions;
   morbidity; mortality; disease prevention
ID METABOLIC SYNDROME; GLOBAL BURDEN; ALCOHOL-CONSUMPTION; VEGETABLE
   INTAKE; PROCESSED FOODS; RISK-FACTORS; HEALTH; BENEFITS; SMOKING; STRESS
AB Background: Behavioral factors, such as smoking, alcohol consumption, stress, poor diet, and physical inactivity, but also sleep deprivation and negative social connections, play a critical role in the development and progression of major chronic diseases. These include cardiovascular diseases, diabetes, chronic respiratory conditions, and cancers. Methods: The objective of this review is to explore the influence of these modifiable risk factors on the global burden of chronic diseases and assess the potential impact of public health interventions and policy changes. Results: The evidence highlights a significant association between behavioral risk factors and increased morbidity and mortality from chronic diseases. Public health interventions and policy changes targeting these modifiable behaviors have shown substantial potential in reducing the prevalence and impact of chronic conditions. Strategies such as smoking cessation programs, dietary improvements, physical activity promotion, and stress reduction are critical in mitigating these risks. Conclusions: Addressing modifiable behavioral factors is essential for the prevention and control of chronic diseases. Bridging the gap between current knowledge and effective implementation of interventions is crucial for improving population health outcomes. Public health strategies focused on modifying key behavioral risks can significantly reduce the burden of chronic diseases, thereby improving overall health and reducing healthcare costs.
C1 [Rahelic, Valentina; Pavic, Eva] Univ Hosp Ctr Zagreb, Dept Nutr & Dietet, Zagreb 10000, Croatia.
   [Rahelic, Valentina; Pavic, Eva] Univ Appl Hlth Sci, Dept Dietet Nutr & Anal Tehn, Zagreb 10000, Croatia.
   [Rahelic, Valentina] Univ North, Dept Food Technol, Koprivnica 48000, Croatia.
   [Perkovic, Tomislav; Romic, Lucija; Rahelic, Dario] Vuk Vrhovac Univ, Merkur Univ Hosp, Clin Diabet Endocrinol & Metab Dis, Zagreb 10000, Croatia.
   [Perkovic, Pavo] Merkur Univ Hosp, Dept Obstet & Gynecol, Zagreb 10000, Croatia.
   [Klobucar, Sanja] Clin Hosp Ctr Rijeka, Dept Internal Med, Div Endocrinol Diabet & Metab Dis, Rijeka 51000, Croatia.
   [Klobucar, Sanja] Univ Rijeka, Fac Med, Dept Internal Med, Rijeka 51000, Croatia.
   [Rahelic, Dario] Catholic Univ Croatia, Sch Med, Zagreb 10000, Croatia.
   [Rahelic, Dario] Josip Juraj Strossmayer Univ Osijek, Sch Med, Osijek 31000, Croatia.
C3 University of Zagreb; UNIVERSITY ZAGREB HOSPITAL; University of Applied
   Health Sciences; University North - Croatia; University of Rijeka;
   University of Rijeka; University of JJ Strossmayer Osijek
RP Rahelic, D (corresponding author), Vuk Vrhovac Univ, Merkur Univ Hosp, Clin Diabet Endocrinol & Metab Dis, Zagreb 10000, Croatia.; Rahelic, D (corresponding author), Catholic Univ Croatia, Sch Med, Zagreb 10000, Croatia.; Rahelic, D (corresponding author), Josip Juraj Strossmayer Univ Osijek, Sch Med, Osijek 31000, Croatia.
EM valentina.rahelic@kbc-zagreb.hr; tomislavperkovic95@gmail.com;
   lucijaromic@gmail.com; pavo.perkovic@zg.t-com.hr;
   sanjaklobucarm@gmail.com; eva.pavic@kbc-zagreb.hr;
   dario.rahelic@gmail.com
RI Rahelic, Dario/AAL-5736-2020; Rahelić, Valentina/GXZ-7491-2022;
   Klobucar, Sanja/P-5969-2018
OI Rahelic, Dario/0000-0002-2901-0646; Klobucar, Sanja/0000-0002-0287-4735;
   Perkovic, Tomislav/0000-0003-0548-334X
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NR 148
TC 1
Z9 1
U1 2
U2 2
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2227-9032
J9 HEALTHCARE-BASEL
JI Healthcare
PD DEC
PY 2024
VL 12
IS 24
AR 2520
DI 10.3390/healthcare12242520
PG 22
WC Health Care Sciences & Services; Health Policy & Services
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services
GA Q3P8K
UT WOS:001383853200001
PM 39765947
OA gold
DA 2025-06-11
ER

PT J
AU Pandey, V
   Singh, A
   Singh, A
   Krishna, A
   Pandey, U
   Tripathi, YB
AF Pandey, Vivek
   Singh, Anusha
   Singh, Ajit
   Krishna, Amitabh
   Pandey, Uma
   Tripathi, Yamini Bhusan
TI Role of oxidative stress and low-grade inflammation in letrozole-induced
   polycystic ovary syndrome in the rat
SO REPRODUCTIVE BIOLOGY
LA English
DT Article
DE Oxidative stress; Inflammation; Polycystic ovary syndrome; Insulin
   resistance
ID C-REACTIVE PROTEIN; INSULIN-RESISTANCE; METABOLIC SYNDROME; LEUKOCYTE
   COUNT; NONOBESE WOMEN; OBESITY; HYPERANDROGENISM; MECHANISMS; METFORMIN;
   EXCESS
AB The aims of the current study were to examine the effects of temporal changes in oxidative stress (OS) and low-grade inflammation in letrozole-treated rats and to correlate these changes with the development of polycystic ovary syndrome (PCOS)-like features. Rats were treated with letrozole for 7, 15 and 21 days to induce PCOS. On day 7 of the treatment, a significant increase in serum testosterone and high sensitive C-reactive protein (hsCRP), the low-grade inflammatory marker, was found in the letrozole treated rats compared to control rats. Moreover, a decreased immunoexpression of insulin receptor coincided with increased body weight. The strong correlation between the levels of hsCRP and lipid peroxidation (LPO) suggests simultaneous development of low-grade inflammation and OS in response to hyperandrogenism, and the role of OS in a formation of cystic follicles in the letrozole animal PCOS model. Therefore, the results of the present study suggest that OS and low-grade inflammation (hsCRP) are the major causes of PCOS induction in this model. (C) 2016 Society for Biology of Reproduction & the Institute of Animal Reproduction and Food Research of Polish Academy of Sciences in Olsztyn. Published by Elsevier Sp. z o.o. All rights reserved.
C1 [Pandey, Vivek; Tripathi, Yamini Bhusan] Banaras Hindu Univ, Dept Med Chem, Fac Ayurueda, Varanasi 221005, Uttar Pradesh, India.
   [Singh, Anusha; Singh, Ajit; Krishna, Amitabh] Banaras Hindu Univ, Fac Sci, Dept Zool, Varanasi 221005, Uttar Pradesh, India.
   [Pandey, Uma] Banaras Hindu Univ, Dept Gynaecol, Varanasi 221005, Uttar Pradesh, India.
C3 Banaras Hindu University (BHU); Banaras Hindu University (BHU); Banaras
   Hindu University (BHU)
RP Tripathi, YB (corresponding author), Banaras Hindu Univ, IMS, Dept Med Chem, Varanasi 221005, Uttar Pradesh, India.
EM Yamini30@gmail.com
RI Singh, Anusha/HNB-5896-2023; Tripathi, Yamini/Q-6160-2019
OI Singh, Ajit/0000-0003-1849-3918; Tripathi, Prof. Yamini
   Bhusan/0000-0002-8093-1109; Singh, Anusha/0000-0002-7850-8213
FU DBT, New Delhi, India
FX We thank Prof. Shyamal. K. Roy, Departments of OB/GYN and Cellular and
   Integrative Physiology, Nebraska medical Center, Omaha, for critically
   reading and editing the manuscript. This study was financially supported
   by the DBT, New Delhi, India.
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NR 37
TC 45
Z9 50
U1 0
U2 9
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1642-431X
EI 2300-732X
J9 REPROD BIOL
JI Reprod. Biol.
PD MAR
PY 2016
VL 16
IS 1
BP 70
EP 77
DI 10.1016/j.repbio.2015.12.005
PG 8
WC Reproductive Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Reproductive Biology
GA DH0MV
UT WOS:000372479200010
PM 26952756
DA 2025-06-11
ER

PT J
AU Bhagya, D
   Prema, L
   Rajamohan, T
AF Bhagya, D.
   Prema, L.
   Rajamohan, T.
TI Therapeutic effects of tender coconut water on oxidative stress in
   fructose fed insulin resistant hypertensive rats
SO ASIAN PACIFIC JOURNAL OF TROPICAL MEDICINE
LA English
DT Article
DE Tender coconut water; Hypertension; Oxidative stress; Hyperinsulinemia;
   Lipid peroxidation; Histopathology
ID METABOLIC SYNDROME; ANTIOXIDANT STATUS; LIPID-PEROXIDATION;
   BLOOD-PRESSURE; BETA; METHYLGLYOXAL; DYSFUNCTION; MECHANISMS; EXTRACT;
   GLUCOSE
AB Objective: To investigate whether tender coconut water (TCW) mitigates oxidative stress in fructose fed hypertensive rats. Methods: Male Sprague Dawley rats were fed with fructose rich diet and treated with TCW (4 mL/100 g of body weight) for 3 subsequent weeks. Systolic blood pressure was measured every three days using the indirect tail cuff method. At the end of the experimental period, plasma glucose and insulin, serum triglycerides and free fatty acids, lipid peroxidation markers (MDA, hydroperoxides and conjugated dienes) and the activities of antioxidant enzymes were analyzed in all the groups. Results: Treatment with TCW significantly lowered the systolic blood pressure and reduced serum triglycerides and free fatty acids. Plasma glucose and insulin levels and lipid peroxidation markers such as MDA, hydroperoxides and conjugated dienes were significantly reduced in fructose fed rats treated with TCW. Activities of antioxidant enzymes are up regulated significantly in TCW treated rats. Histopathological analysis of liver showed that TCW treatment reduced the lipid accumulation and inflammatory infiltration without any significant hepatocellular damage. Conclusions: The overall results suggest that, TCW treatment could prevent and reverse high blood pressure induced by high fructose diet probably by inhibition of lipid peroxidation, upregulation of antioxidant status and improved insulin sensitivity.
C1 [Bhagya, D.; Rajamohan, T.] Univ Kerala, Dept Biochem, Trivandrum 695581, Kerala, India.
   [Prema, L.] Coll Agr, Dept Food Sci & Nutr, Trivandrum, Kerala, India.
C3 University of Kerala
RP Rajamohan, T (corresponding author), Univ Kerala, Dept Biochem, Kariavattom Campus, Trivandrum 695581, Kerala, India.
EM t.rajamohan2010@gmail.com
RI D, Bhagya/AHC-5485-2022
OI D, Dr BHAGYA/0000-0002-9334-4616
FU University of Kerala, Thiruvananthapuram, India
FX First author thank University of Kerala, Thiruvananthapuram, India for
   financial support. We thank Dr. Sankar (Professor and Head, Dept of
   Pathology, Govt. Medical College, Trivandrum, Kerala, India) for helping
   histopathological analysis.
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NR 49
TC 28
Z9 33
U1 0
U2 5
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, Maharashtra, INDIA
SN 1995-7645
EI 2352-4146
J9 ASIAN PAC J TROP MED
JI Asian Pac. J. Trop. Med.
PD APR
PY 2012
VL 5
IS 4
BP 270
EP 276
DI 10.1016/S1995-7645(12)60038-8
PG 7
WC Public, Environmental & Occupational Health; Tropical Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health; Tropical Medicine
GA 926YP
UT WOS:000302869700004
PM 22449517
OA gold
DA 2025-06-11
ER

PT J
AU Wang, ZL
   Chen, NA
   Li, ZY
   Xu, G
   Zhan, XY
   Tang, JY
   Xiao, XH
   Bai, ZF
AF Wang, Zhilei
   Chen, Nian
   Li, Zhiyong
   Xu, Guang
   Zhan, Xiaoyan
   Tang, Jianyuan
   Xiao, Xiaohe
   Bai, Zhaofang
TI The Cytosolic DNA-Sensing cGAS-STING Pathway in Liver Diseases
SO FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
LA English
DT Review
DE DNA-sensing; cyclic GMP-AMP synthase; stimulator of interferon genes;
   liver diseases; cyclic guanosine monophosphate-adenosine monophosphate
ID CYCLIC GMP-AMP; C VIRUS NS4B; PATTERN-RECOGNITION RECEPTORS;
   ENDOPLASMIC-RETICULUM STRESS; I-LIKE RECEPTORS; SENSOR CGAS; RIG-I;
   CELL-DEATH; MITOCHONDRIAL DYSFUNCTION; ENDOGENOUS 2ND-MESSENGER
AB Inflammation is regulated by the host and is a protective response activated by the evolutionarily conserved immune system in response to harmful stimuli, such as dead cells or pathogens. cGAS-STING pathway is a vital natural sensor of host immunity that can defend various tissues and organs against pathogenic infection, metabolic syndrome, cellular stress and cancer metastasis. The potential impact of cGAS-STING pathway in hepatic ischemia reperfusion (I/R) injury, alcoholic/non-alcoholic steatohepatitis (ASH), hepatic B virus infection, and other liver diseases has recently attracted widespread attention. In this review, the relationship between cGAS-STING pathway and the pathophysiological mechanisms and progression of liver diseases is summarized. Additionally, we discuss various pharmacological agonists and antagonists of cGAS-STING signaling as novel therapeutics for the treatment of liver diseases. A detailed understanding of mechanisms and biology of this pathway will lay a foundation for the development and clinical application of therapies for related liver diseases.
C1 [Wang, Zhilei; Tang, Jianyuan] Hosp Chengdu Univ Tradit Chinese Med, TCM Regulating Metab Dis Key Lab Sichuan Prov, Chengdu, Peoples R China.
   [Wang, Zhilei; Xu, Guang; Zhan, Xiaoyan; Xiao, Xiaohe; Bai, Zhaofang] Chinese Peoples Liberat Army Gen Hosp, Med Ctr 5, Dept Liver Dis, Beijing, Peoples R China.
   [Wang, Zhilei; Chen, Nian; Li, Zhiyong; Xiao, Xiaohe] Chengdu Univ Tradit Chinese Med, Sch Pharm, State Key Lab Southwestern Chinese Med Resources, Chengdu, Peoples R China.
   [Xiao, Xiaohe; Bai, Zhaofang] Chinese Peoples Liberat Army Gen Hosp, Med Ctr 5, China Mil Inst Chinese Mat, Beijing, Peoples R China.
C3 Chengdu University of Traditional Chinese Medicine; Chinese People's
   Liberation Army General Hospital; Fifth Medical Center of Chinese PLA
   General Hospital; Chengdu University of Traditional Chinese Medicine;
   Fifth Medical Center of Chinese PLA General Hospital; Chinese People's
   Liberation Army General Hospital
RP Tang, JY (corresponding author), Hosp Chengdu Univ Tradit Chinese Med, TCM Regulating Metab Dis Key Lab Sichuan Prov, Chengdu, Peoples R China.; Xiao, XH; Bai, ZF (corresponding author), Chinese Peoples Liberat Army Gen Hosp, Med Ctr 5, Dept Liver Dis, Beijing, Peoples R China.; Xiao, XH (corresponding author), Chengdu Univ Tradit Chinese Med, Sch Pharm, State Key Lab Southwestern Chinese Med Resources, Chengdu, Peoples R China.; Xiao, XH; Bai, ZF (corresponding author), Chinese Peoples Liberat Army Gen Hosp, Med Ctr 5, China Mil Inst Chinese Mat, Beijing, Peoples R China.
EM tangjianyuan163@163.com; pharmacy_302@126.com; baizf2009@hotmail.com
RI Wang, Zhilei/AAE-7465-2022; Yang, Hongyan/IZQ-2790-2023; Xiao,
   Xiaohe/LTF-2553-2024; Li, Zhiyong/HGE-9677-2022
FU National Natural Science Foundation of China [81874368, 81630100];
   National Science and Technology Major Project "Key New Drug Creation and
   Manufacturing Program" [2017ZX09301022, 2018ZX09101002-001-002]
FX This work was supported by the National Natural Science Foundation of
   China (81874368 and 81630100), the National Science and Technology Major
   Project "Key New Drug Creation and Manufacturing Program"
   (2017ZX09301022 and 2018ZX09101002-001-002).
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NR 164
TC 19
Z9 19
U1 6
U2 35
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-634X
J9 FRONT CELL DEV BIOL
JI Front. Cell. Dev. Biol.
PD JUL 27
PY 2021
VL 9
AR 717610
DI 10.3389/fcell.2021.717610
PG 13
WC Cell Biology; Developmental Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Developmental Biology
GA TX7VM
UT WOS:000683296400001
PM 34386500
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Chandrasekhar, T
   Suchitra, MM
   Pallavi, M
   Rao, PVLNS
   Sachan, A
AF Chandrasekhar, T.
   Suchitra, M. M.
   Pallavi, M.
   Rao, P. V. L. N. Srinivasa
   Sachan, Alok
TI Risk Factors for Cardiovascular Disease in Obese Children
SO INDIAN PEDIATRICS
LA English
DT Article
DE Dyslipidemia; Endothelial dysfunction; Insulin resistance; Oxidative
   stress
ID INSULIN-RESISTANCE; CHILDHOOD OBESITY; PLASMA; ATHEROSCLEROSIS;
   ASSOCIATION; FIBRINOGEN
AB Objective: To study the prevalence of cardiovascular risk factors in pediatric obesity. Methods: 50 obese children (age 5-17y) and 50 apparently healthy non-obese children (body mass index of over 95th percentile and between 5th to 95th percentiles respeptively) using Centre for Disease-Control-growth charts were included. Fasting blood sugar, lipid profile, insulin, homeostasis model assessment of insulin resistance, uric acid, fibrinogen, lipoprotein (a), homocysteine, malondialdehyde, ferric reducing ability of plasma and nitric oxide were measured. Results: Insulin, insulin resistance, triglycerides, uric acid, fibrinogen, malondialdehyde, ferric reducing ability of plasma and nitric oxide were significantly higher (P <0.001) in obese children. Body mass index showed significant positive correlation with insulin r=0.519, P<0.001; insulin resistance r=0.479, P<0.001; uric acid r= 0.289, P=0.005; fibrinogen r=0.461, P<0.001; and nitric oxide r=0.235, P=0.012. Conclusion: Pediatric obesity is associated with dyslipidemia, oxidative stress, insulin resistance and endothelial dysfunction, which are cardiovascular risk factors and components of metabolic syndrome. These children must be targeted for lifestyle and dietary modification.
C1 [Chandrasekhar, T.; Suchitra, M. M.; Pallavi, M.; Rao, P. V. L. N. Srinivasa] Sri Venkateswara Inst Med Sci, Dept Biochem, Tirupati, Andhra Pradesh, India.
   [Sachan, Alok] Sri Venkateswara Inst Med Sci, Dept Endocrinol, Tirupati, Andhra Pradesh, India.
RP Suchitra, MM (corresponding author), Sri Venkateswara Inst Med Sci, Dept Biochem, Tirupati, Andhra Pradesh, India.
EM suchitra.n@rediffmail.com
RI Suchitra, M/IYJ-8163-2023
FU Indian Council of Medical Research (ICMR); Sri Balaji Arogya
   Varaprasadini Scheme (SBAVP) of Sri Venkateswara Institute of Medical
   Sciences, SVIMS University
FX Indian Council of Medical Research (ICMR) and Sri Balaji Arogya
   Varaprasadini Scheme (SBAVP) of Sri Venkateswara Institute of Medical
   Sciences, SVIMS University.
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NR 17
TC 9
Z9 11
U1 0
U2 3
PU SPRINGER INDIA
PI NEW DELHI
PA 7TH FLOOR, VIJAYA BUILDING, 17, BARAKHAMBA ROAD, NEW DELHI, 110 001,
   INDIA
SN 0019-6061
EI 0974-7559
J9 INDIAN PEDIATR
JI Indian Pediatrics
PD SEP
PY 2017
VL 54
IS 9
BP 752
EP 755
PG 4
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA FI8OW
UT WOS:000412262900010
PM 28984255
DA 2025-06-11
ER

PT J
AU Woguia, AL
   Ngondi, JL
   Boudjeko, T
   Rihouey, C
   Oben, EJ
AF Woguia, Alice Louise
   Ngondi, Judith Laure
   Boudjeko, Thaddee
   Rihouey, Christophe
   Oben, Enyong Julius
TI Hypolipidemic and antioxidative effects of dika nut (Irvingia
   gabonensis) seeds and nkui (Trimphetta cordifolia) stem bark
   mucilages in triton WR-1339 induced hyperlipidemic rats
SO FOOD SCIENCE AND BIOTECHNOLOGY
LA English
DT Article
DE mucilage; Irvingia gabonensis; Triumphetta cordifolia; hypolipidemic
   activity; oxidative stress
ID METABOLIC SYNDROME; WHOLE; CHOLESTEROL; OXIDATION; EXTRACT
AB Two different mucilages were extracted from dika nut (Irvingia gabonensis) kernels and nkui (Trimphetta cordifolia) stem barks and the hypolipidemic and antioxidant effects were studied on Triton WR-1339 induced hyperlipidemic rats. The GC analysis revealed that, dika nut mucilage is an arabinogalactan type while nkui is a rhamnogalacturonane type. The mucilage of nkui (200 mg/kg) showed the greatest hypolipidemic effect (p < 0.05). An oxidative stress marker analysis suggested that the level of malonyl dialdehyde was significantly decreased in serum by the 2 mucilages (p < 0.05). There was also a significant decrease in hydroperoxide level for the tested fibers. Moreover, nkui mucilage gave the highest levels in liver homogenate and in the hemolysate and tissues (p < 0.05). The results suggest that the hypolidemic effect of mucilages varies with their chemical nature. They would be effective in the prevention of increase of serum lipid levels, in the reduction of lipid peroxidation and in the improvement of antioxidant status.
C1 [Woguia, Alice Louise; Ngondi, Judith Laure; Boudjeko, Thaddee; Oben, Enyong Julius] Univ Yaounde I, Dept Biochem, Yaounde, Cameroon.
   [Rihouey, Christophe] Univ Rouen, UFR Sci, Serv Commun Chromatog & Spectrometrie Masse, F-76821 Mont St Aignan, France.
C3 University of Yaounde I; Universite de Rouen Normandie
RP Boudjeko, T (corresponding author), Univ Yaounde I, Dept Biochem, Cameroon POB 812, Yaounde, Cameroon.
EM boudjeko@yahoo.com
RI Rihouey, Christophe/KHC-9387-2024
FU Le Ministere Francais des Affaires Etrangeres et Europeennes
FX One of the authors (BT) is thankful to 'Le Ministere Francais des
   Affaires Etrangeres et Europeennes' for financing exchange visits
   between Cameroon and France.
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NR 30
TC 6
Z9 7
U1 0
U2 19
PU KOREAN SOCIETY FOOD SCIENCE & TECHNOLOGY-KOSFOST
PI SEOUL
PA #605, KOREA SCI TECHNOL CENT, 635-4 YEOKSAM-DONG, KANGNAM-GU, SEOUL,
   135-703, SOUTH KOREA
SN 1226-7708
EI 2092-6456
J9 FOOD SCI BIOTECHNOL
JI Food Sci. Biotechnol.
PD DEC
PY 2012
VL 21
IS 6
BP 1715
EP 1721
DI 10.1007/s10068-012-0228-5
PG 7
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA 064ME
UT WOS:000313078600028
DA 2025-06-11
ER

PT J
AU Sebastian, SA
   Padda, I
   Johal, G
AF Sebastian, Sneha Annie
   Padda, Inderbir
   Johal, Gurpreet
TI Cardiovascular-Kidney-Metabolic (CKM) syndrome: A state-of-the-art
   review
SO CURRENT PROBLEMS IN CARDIOLOGY
LA English
DT Review
DE Cardiovascular kidney metabolic syndrome; CKM; Obesity; MetS
ID HEART-FAILURE; RISK DEVELOPMENT; DISEASE; MECHANISMS; MANAGEMENT;
   INHIBITORS; GUIDELINE; EXERCISE; BENEFITS
AB The correlation between obesity, type 2 diabetes mellitus (DM), cardiovascular disease (CVD), and chronic kidney disease (CKD) is an escalating and widely acknowledged epidemic in industrialized nations. Recently, this complex web of interrelated health conditions has been collectively defined as the Cardiovascular-Kidney-Metabolic (CKM) syndrome by the American Heart Association (AHA). The molecular mechanisms underlying CKM disease contain a spectrum of interconnected factors, including hyperglycemia, insulin resistance, heightened activity of the renin-angiotensin-aldosterone system (RAAS), the generation of advanced glycation endproducts, oxidative stress, lipotoxicity, endoplasmic reticulum stress, abnormalities in calcium handling, malfunctioning of mitochondria and impaired energy production, as well as persistent chronic inflammation. Addressing their prevention, management, and treatment is of paramount importance to promote better patient health outcomes. The objective of this review is to provide a comprehensive and critical examination of the current state-of-the-art regarding the recently defined CKM syndrome. This includes an exploration of epidemiological evidence establishing connections between cardio-renal-metabolic diseases, an examination of the underlying pathophysiological mechanisms, and a comprehensive overview of existing treatment modalities.
C1 [Sebastian, Sneha Annie] Azeezia Med Coll, Dept Internal Med, Kollam, Kerala, India.
   [Padda, Inderbir] Richmond Univ, Dept Internal Med, Med Ctr Mt Sinai, Staten Isl, NY USA.
   [Johal, Gurpreet] Univ Washington, Valley Med Ctr, Dept Cardiol, Seattle, WA USA.
   [Sebastian, Sneha Annie] 405,1530 Bayside Ave SW, Airdrie, AB T4B 4B5, Canada.
C3 University of Washington; University of Washington Seattle
RP Sebastian, SA (corresponding author), 405,1530 Bayside Ave SW, Airdrie, AB T4B 4B5, Canada.
EM snehaann1991@gmail.com
RI Padda, Inderbir/AAX-4386-2020; Sebastian, Sneha Annie/JEP-5395-2023
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NR 51
TC 71
Z9 75
U1 26
U2 65
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0146-2806
EI 1535-6280
J9 CURR PROB CARDIOLOGY
JI Curr. Probl. Cardiol.
PD FEB
PY 2024
VL 49
IS 2
AR 102344
DI 10.1016/j.cpcardiol.2023.102344
EA DEC 2023
PG 10
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA II5E0
UT WOS:001165702000001
PM 38103820
DA 2025-06-11
ER

PT J
AU Dupont, C
   Bachelot, G
   Sermondade, N
   Lévy, R
AF Dupont, Charlotte
   Bachelot, Guillaume
   Sermondade, Nathalie
   Levy, Rachel
TI Nutrition and fertility: The male part
SO CAHIERS DE NUTRITION ET DE DIETETIQUE
LA English
DT Article
DE Obesity; Nutrition; Male infertility; Medically assisted reproduction;
   Sperm parameters
ID BODY-MASS INDEX; METABOLIC SYNDROME; OXIDATIVE STRESS; SEMEN QUALITY;
   OBESITY; MEN; INTERVENTIONS; OVERWEIGHT; COUPLES; IMPACT
AB Many lifestyle factors have been identified as risk factors for infertility in men. An unbalanced diet leading to overweight, obesity, metabolic disorders and micronutrient deficien-cies can affect male reproductive functions and decrease the chances of conceiving a healthy child. Obese men may have impaired sperm parameters and a reduced chance of pregnancy following assisted reproductive technologies. Oxidative stress seems to be one of the main mechanisms linking diet and male fertility. Weight loss could reverse the adverse effects of obesity. Although interventional studies proving the effectiveness of a pre-conceptional inter-vention allowing an improvement in men's lifestyle on the chances of pregnancy are lacking, more and more studies highlight the importance of a balanced diet and of physical activity to improve couples' fertility. Men who wish to conceive can therefore be offered practical advice and education to enable them to maintain or achieve the public health recommendations that encourage a balanced diet such as the "Mediterranean diet". (c) 2023 Published by Elsevier Masson SAS on behalf of Societe francaise de nutrition.
C1 [Dupont, Charlotte; Bachelot, Guillaume; Sermondade, Nathalie; Levy, Rachel] Sorbonne Univ, Hop Tenon, AP HP, Inserm,St Antoine Res Ctr,Serv Biol Reprod CECOS,, F-75020 Paris, France.
C3 Assistance Publique Hopitaux Paris (APHP); Sorbonne Universite; Hopital
   Universitaire Saint-Antoine - APHP; Institut National de la Sante et de
   la Recherche Medicale (Inserm); Hopital Universitaire Tenon - APHP
RP Dupont, C (corresponding author), Sorbonne Univ, Hop Tenon, AP HP, Inserm,St Antoine Res Ctr,Serv Biol Reprod CECOS,, F-75020 Paris, France.
EM charlotte.dupont@aphp.fr; guillaume.bachelot@aphp.fr;
   nathalie.sermondade@aphp.fr; rachel.levy@aphp.fr
RI Bachelot, Guillaume/IUQ-6294-2023; Sermondade, Nathalie/NEU-1253-2025;
   Dupont, Charlotte/AAL-8780-2020
OI Bachelot, Guillaume/0000-0002-4175-4816
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NR 35
TC 0
Z9 0
U1 3
U2 7
PU MASSON EDITEUR
PI MOULINEAUX CEDEX 9
PA 21 STREET CAMILLE DESMOULINS, ISSY, 92789 MOULINEAUX CEDEX 9, FRANCE
SN 0007-9960
J9 CAH NUTR DIET
JI Cah. Nutr. Diet.
PD DEC
PY 2023
VL 58
IS 6
BP 361
EP 365
DI 10.1016/j.cnd.2023.09.003
EA DEC 2023
PG 5
WC Nutrition & Dietetics
WE Emerging Sources Citation Index (ESCI)
SC Nutrition & Dietetics
GA DX8T9
UT WOS:001135485100001
DA 2025-06-11
ER

PT J
AU Hayasaka, S
   Kimura, F
   Kato, S
   Shimizu, N
   Ito, J
   Higuchi, O
   Izumisawa, K
   Miyazawa, T
   Nakagawa, K
AF Hayasaka, Saki
   Kimura, Fumiko
   Kato, Shunji
   Shimizu, Naoki
   Ito, Junya
   Higuchi, Oki
   Izumisawa, Katsuhiro
   Miyazawa, Teruo
   Nakagawa, Kiyotaka
TI High-fat Diet Increases Phospholipid Peroxidation in the Liver of Mature
   Fischer 344 Rats
SO JOURNAL OF OLEO SCIENCE
LA English
DT Article; Proceedings Paper
CT 3rd International Conference on Rice Bran Oil (ICRBO)
CY OCT 24-25, 2016
CL Univ Tokyo, ITO Int Res Ctr, Bunkyo, JAPAN
HO Univ Tokyo, ITO Int Res Ctr
DE antioxidant; liver; oxidative stress; phosphatidylcholine hydroperoxide;
   rat
ID PHOSPHATIDYLCHOLINE HYDROPEROXIDE; CARBON-TETRACHLORIDE; METABOLIC
   SYNDROME; ALPHA-TOCOPHEROL; LIPID-METABOLISM; PLASMA; MALONDIALDEHYDE;
   OBESITY; CHROMATOGRAPHY; ACCUMULATION
AB Phospholipid peroxidation is considered to be involved in the pathophysiology of various diseases. While dietary antioxidants are believed to help prevent these diseases via inhibition of phospholipid peroxidation, further evaluation is needed to prove this hypothesis. For this, it is crucial to establish an animal model with accelerated phospholipid peroxidation. In this study, we hypothesized that a combination of aging and high-fat diet feeding may accelerate phospholipid peroxidation in vivo. High-fat diets were fed to mature and juvenile Fischer 344 rats for 12 weeks. The mature rats in particular accumulated body fat and liver phosphatidylcholine hydroperoxide (PCOOH). Interestingly, the increase in PCOOH levels was abrogated by the co-administration of antioxidants to mature rats. This may be attributed to factors including the decrease in body fat, functions of vitamin E, and/or the involvement of antioxidant-related genes, each caused by antioxidant administration. These results indicate that the high-fat diet-fed aging animal model may be suitable for investigation of the relationship between phospholipid peroxidation, oxidative stress-related diseases, and dietary antioxidants.
C1 [Hayasaka, Saki; Kato, Shunji; Shimizu, Naoki; Ito, Junya; Miyazawa, Teruo; Nakagawa, Kiyotaka] Tohoku Univ, Grad Sch Agr Sci, Food & Biodynam Chem Lab, Sendai, Miyagi, Japan.
   [Kimura, Fumiko] Shokei Gakuin Univ, Dept Human Hlth & Nutr, Natori, Miyagi, Japan.
   [Higuchi, Oki] Biodynam Plant Inst CO Ltd, Sapporo, Hokkaido, Japan.
   [Izumisawa, Katsuhiro] Eisai & Co Ltd, Tokyo, Japan.
   [Miyazawa, Teruo] Tohoku Univ, NICHe, Food Biotechnol Innovat Project, Sendai, Miyagi, Japan.
C3 Tohoku University; Eisai Co Ltd; Tohoku University
RP Nakagawa, K (corresponding author), Tohoku Univ, Grad Sch Agr Sci, Food & Biodynam Chem Lab, Sendai, Miyagi, Japan.
EM nkgw@biochem.tohoku.ac.jp
RI Ito, Junya/KPA-7635-2024; Shimizu, Naoki/AAF-3554-2020; Kato,
   Shunji/ABG-8440-2021; Shimizu, Naoki/HPE-8265-2023
OI Ito, Junya/0000-0001-9190-4969; Shimizu, Naoki/0000-0002-1892-5795;
   Kato, Shunji/0000-0003-4659-9541
FU JSPS KAKENHI [15H04497, 15K14726]; Grants-in-Aid for Scientific Research
   [15H04497, 15K14726] Funding Source: KAKEN
FX This study was partly supported by a JSPS KAKENHI Grant (Number 15H04497
   and 15K14726).
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NR 37
TC 3
Z9 4
U1 0
U2 2
PU JAPAN OIL CHEMISTS SOC
PI TOKYO
PA YUSHI KOGYO KAIKAN BLDG, 13-11, NIHONBASHI 3-CHOME, CHUO-KU, TOKYO,
   103-0027, JAPAN
SN 1345-8957
EI 1347-3352
J9 J OLEO SCI
JI J. Oleo Sci.
PD JUN
PY 2017
VL 66
IS 6
SI SI
BP 607
EP 614
DI 10.5650/jos.ess16225
PG 8
WC Chemistry, Applied; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Chemistry; Food Science & Technology
GA EW6AR
UT WOS:000402588100010
PM 28515377
OA gold
DA 2025-06-11
ER

PT J
AU Freitas, P
   Carvalho, D
AF Freitas, P.
   Carvalho, D.
TI Lipodystrophy: beyond generalization?
SO PANMINERVA MEDICA
LA English
DT Article
DE Lipodystrophy; Congenital Generalized; HIV-associated lipodystrophy
   syndrome; Adipose tissue; Metabolic diseases; Aging
ID HIV-INFECTED PERSONS; AGE-RELATED COMORBIDITIES; SEVERE
   INSULIN-RESISTANCE; COPY NUMBER VARIATION; ENCODING LAMIN A/C;
   ADIPOSE-TISSUE; MANDIBULOACRAL DYSPLASIA; CARDIOVASCULAR-DISEASE;
   PROTEASE INHIBITORS; OXIDATIVE STRESS
AB Genetic and acquired lipodystrophies are disorders of adipose tissue distribution. In this review we will emphasize its phenotype, metabolic and genetic particularities. Special stress will be given to the most prevalent lipodystrophy -that associated with HIV infection - describing the similarities with congenital lipodystrophies and its pathogenic mechanisms. It will be discussed the pathways involved in development, differentiation and death of adipocytes, emphasizing that both genetic and acquired, including that associated with HIV can induce changes in adipogenesis and how the two main adipose tissue dysfunctions - obesity and lipodystrophy - can cause a similar metabolic. profile (diabetes, hypertension, dyslipidemia) with increased cardiovascular risk. Rare monogenic laminopathies and other genetic lipodystrophies could be relevant to understand common pathways - physiopathology of aging, atherosclerosis process, vascular endothelial cell dysfunction, frailty syndrome and common disorders such as type 2 diabetes, insulin resistance, dyslipidemia, hypertension and metabolic syndrome. Also, some lipodystrophies can be associated with premature aging and precocious cardiovascular disease. The Authors aimed to give a focus on the particularities of each of the issues addressed.
C1 Ctr Hosp Sao Joao, Dept Endocrinol, Oporto, Portugal.
   Univ Porto, Sch Med, P-4200 Oporto, Portugal.
C3 Sao Joao Hospital; Universidade do Porto
RP Freitas, P (corresponding author), Univ Porto, Sch Med, Ctr Hosp Sao Joao, Dept Endocrinol, Alameda Hernani Monteiro, P-4200 Oporto, Portugal.
EM pau-la_freitas@sapo.pt
RI Carvalho, Davide/AAR-2081-2020; Freitas, Paula/HNP-1602-2023
OI Freitas, Paula/0000-0002-8732-8046; Carvalho, Davide/0000-0002-3156-3741
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NR 120
TC 4
Z9 4
U1 0
U2 4
PU EDIZIONI MINERVA MEDICA
PI TURIN
PA CORSO BRAMANTE 83-85 INT JOURNALS DEPT., 10126 TURIN, ITALY
SN 0031-0808
EI 1827-1898
J9 PANMINERVA MED
JI Panminerva Medica
PD SEP
PY 2013
VL 55
IS 3
BP 253
EP 268
PG 16
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 286OI
UT WOS:000329478200002
PM 24088799
DA 2025-06-11
ER

PT J
AU Martins, AR
   Nachbar, RT
   Gorjao, R
   Vinolo, MA
   Festuccia, WT
   Lambertucci, RH
   Cury-Boaventura, MF
   Silveira, LR
   Curi, R
   Hirabara, SM
AF Martins, Amanda R.
   Nachbar, Renato T.
   Gorjao, Renata
   Vinolo, Marco A.
   Festuccia, William T.
   Lambertucci, Rafael H.
   Cury-Boaventura, Maria F.
   Silveira, Leonardo R.
   Curi, Rui
   Hirabara, Sandro M.
TI Mechanisms underlying skeletal muscle insulin resistance induced by
   fatty acids: importance of the mitochondrial function
SO LIPIDS IN HEALTH AND DISEASE
LA English
DT Review
DE Skeletal muscle; Insulin resistance; Saturated fatty acids;
   Mitochondrial dysfunction
ID PROTEIN-KINASE-C; FACTOR-KAPPA-B; PHOSPHATIDYLINOSITOL 3-KINASE
   ACTIVITY; ELECTRON-TRANSPORT CHAIN; NITRIC-OXIDE SYNTHASE; OXIDATIVE
   STRESS; REACTIVE OXYGEN; UNCOUPLING PROTEIN-3; RECEPTOR SUBSTRATE-1;
   3T3-L1 ADIPOCYTES
AB Insulin resistance condition is associated to the development of several syndromes, such as obesity, type 2 diabetes mellitus and metabolic syndrome. Although the factors linking insulin resistance to these syndromes are not precisely defined yet, evidence suggests that the elevated plasma free fatty acid (FFA) level plays an important role in the development of skeletal muscle insulin resistance. Accordantly, in vivo and in vitro exposure of skeletal muscle and myocytes to physiological concentrations of saturated fatty acids is associated with insulin resistance condition. Several mechanisms have been postulated to account for fatty acids-induced muscle insulin resistance, including Randle cycle, oxidative stress, inflammation and mitochondrial dysfunction. Here we reviewed experimental evidence supporting the involvement of each of these propositions in the development of skeletal muscle insulin resistance induced by saturated fatty acids and propose an integrative model placing mitochondrial dysfunction as an important and common factor to the other mechanisms.
C1 [Martins, Amanda R.; Nachbar, Renato T.; Vinolo, Marco A.; Festuccia, William T.; Silveira, Leonardo R.; Curi, Rui; Hirabara, Sandro M.] Univ Sao Paulo, Inst Biomed Sci, Dept Physiol & Biophys, BR-05508000 Sao Paulo, Brazil.
   [Gorjao, Renata; Lambertucci, Rafael H.; Cury-Boaventura, Maria F.; Hirabara, Sandro M.] Cruzeiro Univ, Inst Phys Act Sci & Sports, Postgrad Program Human Movement Sci, Sao Paulo, Brazil.
C3 Universidade de Sao Paulo; Institute Biomed Science, University Sao
   Paulo; Universidade Cruzeiro do Sul
RP Hirabara, SM (corresponding author), Univ Sao Paulo, Inst Biomed Sci, Dept Physiol & Biophys, Av Prof Lineu Prestes,1524 Butanta, BR-05508000 Sao Paulo, Brazil.
EM sandromh@yahoo.com.br
RI Curi, Rui/C-9351-2012; Vinolo, Marco/K-3753-2012; Festuccia,
   William/C-7618-2012; Hirabara, Sandro Massao/C-4014-2012; Lambertucci,
   Rafael Herling/C-6975-2012; Gorjao, Renata/D-4130-2013; Cury-Boaventura,
   Maria Fernanda/B-3945-2012
OI Vinolo, Marco Aurelio/0000-0003-1335-760X; Hirabara, Sandro
   Massao/0000-0002-7392-0444; Festuccia, William/0000-0003-4769-0806;
   Lambertucci, Rafael Herling/0000-0001-8532-2639; Silveira,
   Leonardo/0000-0001-9369-1047; Gorjao, Renata/0000-0002-9655-1477;
   Cury-Boaventura, Maria Fernanda/0000-0002-1596-0624; Nachbar, Renato
   Tadeu/0000-0002-4972-6342
FU FAPESP; CAPES; CNPq/National Institute of Sciences and Technology in
   Obesity and Diabetes; Center of Lipid Research And Education (CLEAR)
FX This study is supported by grants from FAPESP, CAPES, CNPq/National
   Institute of Sciences and Technology in Obesity and Diabetes, and Center
   of Lipid Research And Education (CLEAR).
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NR 146
TC 212
Z9 248
U1 1
U2 65
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1476-511X
J9 LIPIDS HEALTH DIS
JI Lipids Health Dis.
PD FEB 23
PY 2012
VL 11
AR 30
DI 10.1186/1476-511X-11-30
PG 11
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA 918AN
UT WOS:000302221300001
PM 22360800
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Saluk-Juszczak, J
   Kolodziejczyk, J
   Tsirigotis-Woloszczak, M
   Pawlaczyk, I
   Wachowicz, B
   Gancarz, R
AF Saluk-Juszczak, Joanna
   Kolodziejczyk, Joanna
   Tsirigotis-Woloszczak, Marta
   Pawlaczyk, Izabela
   Wachowicz, Barbara
   Gancarz, Roman
TI Agrimonia - biological activity and perspectives for medicinal
   application. Part I
SO MENOPAUSE REVIEW-PRZEGLAD MENOPAUZALNY
LA English
DT Article
DE Agrimonia; biological activity; medicinal application
ID NITRIC-OXIDE; AQUEOUS EXTRACT; PILOSA LEDEB.; EUPATORIA L.;
   INFLAMMATION; FLAVONOIDS; PROANTHOCYANIDINS; INHIBITION; GLUTAMATE;
   STRESS
AB The menopause-related alteration in a woman's body may include a variety of disorders, such as obesity, metabolic syndrome, changes in immune response or haemostatic parameters, and oxidative stress. Some plant-derived substances have been used for many years as an alternative for oestrogen therapy in the treatment of various menopausal symptoms. Among these compounds, the best known are isoflavones. However, also other biologically active compounds, that are present in herbs, should be taken into account as potential therapeutic agents. The growing number of reports has confirmed favourable effects of plants belonging to the Agrimonia genus. Three species of them occur in Poland: Agrimonia eupatoria L, Agrimonia pilosa Ledeb., and Agrimonia procera Wallr. In the present review, the available data and recent findings on the potential use of different plants from Agrimonia genus in prevention and therapy of various disturbances of the inflammatory system and cardiovascular disorders are described. One of the most important aspects of the medicinal application of Agrimonia plants is their possible role in the protection of the cardiovascular system against changes associated with menopause.
C1 [Saluk-Juszczak, Joanna; Kolodziejczyk, Joanna; Wachowicz, Barbara] Univ Lodz, Dept Gen Biochem, PL-90236 Lodz, Poland.
   [Saluk-Juszczak, Joanna; Kolodziejczyk, Joanna; Pawlaczyk, Izabela; Wachowicz, Barbara; Gancarz, Roman] Reg Specialist Hosp Wroclaw, Ctr Res & Dev, Wroclaw, Poland.
   [Tsirigotis-Woloszczak, Marta; Pawlaczyk, Izabela; Gancarz, Roman] Wroclaw Univ Technol, Div Med Chem & Microbiol, PL-50370 Wroclaw, Poland.
C3 University of Lodz; Wroclaw University of Science & Technology
RP Saluk-Juszczak, J (corresponding author), Univ Lodz, Dept Gen Biochem, Ul Pomorska 141-143, PL-90236 Lodz, Poland.
RI Kolodziejczyk-Czepas, Joanna/ABD-2239-2021; Pawlaczyk-Graja,
   Izabela/G-7210-2016
OI Saluk-Bijak, Joanna/0000-0002-1197-1713
FU European Regional Development Fund; Polish Government; Wroclaw
   University of Technology
FX This work is supported by the European Regional Development Fund and the
   Polish Government (Operational Programme - Innovative Economy) under the
   grant "WROVASC - Integrated Cardiovascular Centre", being implemented in
   2007-2013, and by Wroclaw University of Technology.
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NR 34
TC 1
Z9 2
U1 0
U2 13
PU TERMEDIA PUBLISHING HOUSE LTD
PI POZNAN
PA KLEEBERGA ST 2, POZNAN, 61-615, POLAND
SN 1643-8876
EI 2299-0038
J9 MENOPAUSE REV
JI Prz. Menopauzalny
PD OCT
PY 2011
VL 10
IS 5
BP 415
EP 418
PG 4
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA 849SH
UT WOS:000297144900014
DA 2025-06-11
ER

PT J
AU Malaguarnera, M
   Di Rosa, M
   Nicoletti, F
   Malaguarnera, L
AF Malaguarnera, Mariano
   Di Rosa, Michelino
   Nicoletti, Ferdinando
   Malaguarnera, Lucia
TI Molecular mechanisms involved in NAFLD progression
SO JOURNAL OF MOLECULAR MEDICINE-JMM
LA English
DT Review
DE Non-alcoholic steatohepatitis; Hepatocellular damage; Insulin
   resistance; Oxidative stress; Gene's abnormality
ID NONALCOHOLIC FATTY LIVER; TUMOR-NECROSIS-FACTOR; ACTIVATED
   PROTEIN-KINASE; TRIGLYCERIDE TRANSFER PROTEIN; TRANSCRIPTION FACTOR
   FOXO1; HEPATIC STELLATE CELLS; NF-KAPPA-B; INSULIN-RECEPTOR SUBSTRATE-1;
   STRESS-RELATED PARAMETERS; ACETYL-COA CARBOXYLASE-2
AB Non-alcoholic fatty liver disease (NAFLD) is an emerging metabolic-related disorder characterized by fatty infiltration of the liver in the absence of alcohol consumption. NAFLD ranges from simple steatosis to non-alcoholic steatohepatitis (NASH), which might progress to end-stage liver disease. This progression is related to the insulin resistance, which is strongly linked to the metabolic syndrome consisting of central obesity, diabetes mellitus, and hypertension. Earlier, the increased concentration of intracellular fatty acids within hepatocytes leads to steatosis. Subsequently, multifactorial complex interactions between nutritional factors, lifestyle, and genetic determinants promote necrosis, inflammation, fibrosis, and hepatocellular damage. Up to now, many studies have revealed the mechanism associated with insulin resistance, whereas the mechanisms related to the molecular components have been incompletely characterized. This review aims to assess the potential molecular mediators initiating and supporting the progression of NASH to establish precocious diagnosis and to plan more specific treatment for this disease.
C1 [Di Rosa, Michelino; Nicoletti, Ferdinando; Malaguarnera, Lucia] Univ Catania, Dept Biomed Sci, I-95124 Catania, Italy.
   [Malaguarnera, Mariano] Univ Catania, Dept Internal Med, I-95124 Catania, Italy.
C3 University of Catania; University of Catania
RP Malaguarnera, L (corresponding author), Univ Catania, Dept Biomed Sci, Via Androne 83, I-95124 Catania, Italy.
EM lucmal@mbox.unict.it
RI Malaguarnera, Lucia/K-5530-2018; NICOLETTI, Ferdinando/M-4428-2016; Di
   Rosa, Michelino/B-5807-2013
OI MALAGUARNERA, Lucia/0000-0002-5171-7963; NICOLETTI,
   Ferdinando/0000-0002-4570-8462; Malaguarnera, Lucia/0000-0002-4516-7571;
   Di Rosa, Michelino/0000-0002-1837-9325
FU Ministry of Health
FX We acknowledge financial support from the Ministry of Health.
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NR 171
TC 238
Z9 264
U1 1
U2 34
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0946-2716
EI 1432-1440
J9 J MOL MED
JI J. Mol. Med.
PD JUL
PY 2009
VL 87
IS 7
BP 679
EP 695
DI 10.1007/s00109-009-0464-1
PG 17
WC Genetics & Heredity; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Genetics & Heredity; Research & Experimental Medicine
GA 462HH
UT WOS:000267341200004
PM 19352614
DA 2025-06-11
ER

PT J
AU Vaisman, N
   Niv, E
AF Vaisman, Nachum
   Niv, Eva
TI Daily consumption of red grape cell powder in a dietary dose improves
   cardiovascular parameters: a double blind, placebo-controlled,
   randomized study
SO INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION
LA English
DT Article
DE Flow-mediated dilatation; hypertension; lipid peroxidation; red grape
   cells
ID CORONARY-ARTERY-DISEASE; VASCULAR ENDOTHELIAL FUNCTION; FLOW-MEDIATED
   DILATION; BLOOD-PRESSURE; NITRIC-OXIDE; WINE POLYPHENOLS; PRIMARY
   PREVENTION; METABOLIC SYNDROME; BRACHIAL-ARTERY; HEART-DISEASE
AB Consumption of polyphenol-rich food and food ingredient such as grape and grape products improved various cardiovascular parameters. In this study, we investigate the effect of dietary daily consumption of red grape cell powder (RGC) on blood pressure (BP) and flow-mediated dilatation (FMD) as well as on oxidative stress in 50 subjects with prehypertension and mild hypertension. The subjects were randomized into groups that consumed 200, 400 mg RGC or placebo daily for 12 weeks. RGC consumption was associated with an improvement of FMD (p = 0.013). There was a significant decrease in lipid peroxidation (p = 0.013) after 12 weeks in a combined RGC-treated group. The diastolic BP decreased significantly in the 200 mg RGC group compared to the placebo group (p = 0.032). Our results indicate that a daily supplementation, of red grape cell powder, for 12 weeks affects endothelial function, diastolic BP and oxidative stress without any adverse effects.
C1 [Vaisman, Nachum; Niv, Eva] Tel Aviv Univ, Sackler Fac Med, Tel Aviv Sourasky Med Ctr, Unit Clin Nutr, IL-69978 Tel Aviv, Israel.
C3 Tel Aviv University; Sackler Faculty of Medicine; Tel Aviv Sourasky
   Medical Center
RP Vaisman, N (corresponding author), Tel Aviv Sourasky Med Ctr, Unit Clin Nutr, 6 Wiezmann St, IL-64239 Tel Aviv, Israel.
EM Nachumv@Tlvmc.Gov.Il
FU Bioharvest Ltd.
FX Bioharvest Ltd. supplied the study material and financial support.
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NR 65
TC 45
Z9 46
U1 0
U2 10
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0963-7486
EI 1465-3478
J9 INT J FOOD SCI NUTR
JI Int. J. Food Sci. Nutr.
PD MAY
PY 2015
VL 66
IS 3
BP 342
EP 349
DI 10.3109/09637486.2014.1000840
PG 8
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA CI7OA
UT WOS:000354952000016
PM 25666417
DA 2025-06-11
ER

PT J
AU Takahashi, Y
   Iida, K
   Takahashi, K
   Yoshioka, S
   Fukuoka, H
   Takeno, R
   Imanaka, M
   Nishizawa, H
   Takahashi, M
   Seo, Y
   Hayashi, Y
   Kondo, T
   Okimura, Y
   Kaji, H
   Kitazawa, R
   Kitazawa, S
   Chihara, K
AF Takahashi, Yutaka
   Iida, Keiji
   Takahashi, Kentaro
   Yoshioka, Shiro
   Fukuoka, Hidenori
   Takeno, Ryoko
   Imanaka, Mari
   Nishizawa, Hitoshi
   Takahashi, Michiko
   Seo, Yasushi
   Hayashi, Yoshitake
   Kondo, Takuma
   Okimura, Yasuhiko
   Kaji, Hidesuke
   Kitazawa, Riko
   Kitazawa, Sohei
   Chihara, Kazuo
TI Growth hormone reverses nonalcoholic steatohepatitis in a patient with
   adult growth hormone deficiency
SO GASTROENTEROLOGY
LA English
DT Article
ID FATTY LIVER-DISEASE; CARDIOVASCULAR RISK MARKERS; REPLACEMENT THERAPY;
   ENDOTHELIAL FUNCTION; INSULIN-RESISTANCE; HEART-DISEASE;
   HYPOPITUITARISM; MORTALITY; DAMAGE; WOMEN
AB Background & Aims: Nonalcoholic steatohepatitis (NASH) is an emerging progressive hepatic disease and demonstrates steatosis, inflammation, and fibrosis. Insulin resistance is a common feature in the development of NASH. Molecular pathogenesis of NASH consists of 2 steps: triglyceride accumulation in hepatocytes with insulin resistance and an enhanced oxidative stress caused by reactive oxygen species. Interestingly, NASH demonstrates a striking similarity to the pathologic conditions observed in adult growth hormone deficiency (AGHD). AGHD is characterized by decreased lean body mass, increased visceral adiposity, abnormal lipid profile, and insulin resistance. Moreover, liver dysfunctions with hyperlipidemia and nonalcoholic fatty liver disease (NAFLD) are frequently observed in patients with AGHD, and it is accompanied by metabolic syndrome. Methods: We studied a case diagnosed as NASH with hyperlipidemia in AGHD. The effect of GH-replacement therapy on the patient was analyzed. Results: Six months of GH-replacement therapy in the patient drastically ameliorated NASH and the abnormal lipid profile concomitant with a marked reduction in oxidative stress. Conclusions: These results suggest that GH plays an essential role in the metabolic and redox regulation in the liver.
C1 Kobe Univ, Grad Sch Med, Dept Clin Mol Med, Div Endocrinol Metab Neurol & Hematol Oncol,Chuo, Kobe, Hyogo 6500017, Japan.
   Kobe Univ, Grad Sch Med, Dept Clin Mol Med, Div Diabet Digest & Kidney Dis, Kobe, Hyogo 6500017, Japan.
   Kobe Univ, Grad Sch Med, Dept Biomed Informat, Int Ctr Med Res & Treatment,Div Mol Med & Med Gen, Kobe, Hyogo 6500017, Japan.
   Kondo Pediat Clin, Osaka, Japan.
   Kobe Univ, Sch Med, Dept Basic Allied Med, Kobe, Hyogo 657, Japan.
   Coll Nursing Art & Culture, Akashi, Hyogo, Japan.
   Kobe Univ, Grad Sch Med, Dept Biomed Informat, Div Mol Pathol, Kobe, Hyogo 657, Japan.
C3 Kobe University; Kobe University; Kobe University; Kobe University; Kobe
   University
RP Takahashi, Y (corresponding author), Kobe Univ, Grad Sch Med, Dept Clin Mol Med, Div Endocrinol Metab Neurol & Hematol Oncol,Chuo, 7-5-2 Kusunoki Cho, Kobe, Hyogo 6500017, Japan.
EM takahash@med.kobe-u.ac.jp
RI Hidenori, Fukuoka/AAK-1812-2020; Iida, Keiji/ABB-5126-2021; Fukuoka,
   Hidenori/AHC-2224-2022; Kitazawa, Sohei/E-5602-2010
OI Fukuoka, Hidenori/0000-0001-9255-653X; Iida, Keiji/0000-0002-1516-7757;
   Kitazawa, Sohei/0000-0002-7466-7356
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NR 27
TC 142
Z9 156
U1 0
U2 2
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0016-5085
J9 GASTROENTEROLOGY
JI Gastroenterology
PD MAR
PY 2007
VL 132
IS 3
BP 938
EP 943
DI 10.1053/j.gastro.2006.12.024
PG 6
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 149YH
UT WOS:000245182300019
PM 17324404
OA Bronze
DA 2025-06-11
ER

PT J
AU Matthews, KA
   Jennings, JR
   Lee, L
   Pardini, DA
AF Matthews, Karen A.
   Jennings, J. Richard
   Lee, Laisze
   Pardini, Dustin A.
TI Bullying and Being Bullied in Childhood Are Associated With Different
   Psychosocial Risk Factors for Poor Physical Health in Men
SO PSYCHOLOGICAL SCIENCE
LA English
DT Article
DE bully; race; cardiovascular risk; longitudinal
ID SOCIOECONOMIC-STATUS; CARDIOVASCULAR REACTIVITY; STRESS; VICTIMIZATION;
   INFLAMMATION; INVOLVEMENT; DISEASE; PURPOSE; IMPACT; SCHOOL
AB Bullying and being bullied in childhood are both linked with later adjustment problems. The impact of childhood bullying on risk for poor physical health in adulthood is understudied. Black and White men (n = 305; mean age = 32.3 years) enrolled in the Pittsburgh Youth Study since the first grade underwent a comprehensive assessment of psychosocial, behavioral, and biological risk factors for poor health. Indices of bullying and being bullied were created by averaging annual ratings collected from participants and their caregivers when the participants were 10 to 12 years old. Results showed that being a bully in childhood was associated with greater stress and aggression and poorer health behaviors in adulthood, whereas being a victim of bullies in childhood was associated with lower socioeconomic resources, less optimism, and greater unfair treatment in adulthood. Unexpectedly, neither bullying nor being bullied in childhood was related to inflammation or metabolic syndrome. Bullying and being bullied in childhood were associated with distinct domains of psychosocial risk in adulthood that may later lead to poor physical health.
C1 [Matthews, Karen A.; Jennings, J. Richard; Lee, Laisze] Univ Pittsburgh, Dept Psychiat, Pittsburgh, PA 15260 USA.
   [Pardini, Dustin A.] Arizona State Univ, Dept Criminol & Criminal Justice, Tempe, AZ 85287 USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE); University
   of Pittsburgh; Arizona State University; Arizona State University-Tempe
RP Matthews, KA (corresponding author), 3811 OHara St, Pittsburgh, PA 15213 USA.
EM matthewska@upmc.edu
RI Pardini, Dustin/E-3615-2013
FU National Heart, Lung, and Blood Institute [R01-HL111802]; National
   Institute on Drug Abuse [DA411018]; National Institute of Mental Health
   [MH48890, MH50778]; Pew Charitable Trusts; Office of Juvenile Justice
   and Delinquency Prevention [96-MU-FX-0012]
FX This research was supported by National Heart, Lung, and Blood Institute
   Grant R01-HL111802. Data collection for the Pittsburgh Youth Study was
   funded by National Institute on Drug Abuse Grant DA411018, National
   Institute of Mental Health Grants MH48890 and MH50778, the Pew
   Charitable Trusts, and Office of Juvenile Justice and Delinquency
   Prevention Grant 96-MU-FX-0012.
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NR 45
TC 29
Z9 36
U1 2
U2 43
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0956-7976
EI 1467-9280
J9 PSYCHOL SCI
JI Psychol. Sci.
PD JUN
PY 2017
VL 28
IS 6
BP 808
EP 821
DI 10.1177/0956797617697700
PG 14
WC Psychology, Multidisciplinary
WE Social Science Citation Index (SSCI)
SC Psychology
GA EX0FK
UT WOS:000402895100011
PM 28452573
OA Green Accepted, Green Published
DA 2025-06-11
ER

PT J
AU Minatel, IO
   Francisqueti, FV
   Corrêa, CR
   Lima, GPP
AF Minatel, Igor Otavio
   Francisqueti, Fabiane Valentini
   Correa, Camila Renata
   Pereira Lima, Giuseppina Pace
TI Antioxidant Activity of γ-Oryzanol: A Complex Network of Interactions
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE gamma-oryzanol; ferulic acid; antioxidant capacity; dyslipidemia;
   obesity; inflammation
ID ENDOPLASMIC-RETICULUM STRESS; NF-KAPPA-B; FATTY-ACID SYNTHASE; RICE BRAN
   OIL; BROWN RICE; OXIDATIVE STRESS; ADIPOSE-TISSUE; DIETARY FIBER;
   ADIPOCYTE DIFFERENTIATION; PARKINSONS-DISEASE
AB gamma-oryzanol (Orz), a steryl ferulate extracted from rice bran layer, exerts a wide spectrum of biological activities. In addition to its antioxidant activity, Orz is often associated with cholesterol-lowering, anti-inflammatory, anti-cancer and anti-diabetic effects. In recent years, the usefulness of Orz has been studied for the treatment of metabolic diseases, as it acts to ameliorate insulin activity, cholesterol metabolism, and associated chronic inflammation. Previous studies have shown the direct action of Orz when downregulating the expression of genes that encode proteins related to adiposity (CCAAT/enhancer binding proteins (C/EBPs)), inflammatory responses (nuclear factor kappa-B (NF-kappa B)), and metabolic syndrome (peroxisome proliferator-activated receptors (PPARs)). It is likely that this wide range of beneficial activities results from a complex network of interactions and signals triggered, and/or inhibited by its antioxidant properties. This review focuses on the significance of Orz in metabolic disorders, which feature remarkable oxidative imbalance, such as impaired glucose metabolism, obesity, and inflammation.
C1 [Minatel, Igor Otavio; Pereira Lima, Giuseppina Pace] Sao Paulo State Univ, Inst Biosci, Dept Chem & Biochem, BR-18618689 Botucatu, SP, Brazil.
   [Francisqueti, Fabiane Valentini; Correa, Camila Renata] Sao Paulo State Univ, Botucatu Med Sch, Dept Pathol, BR-18618970 Botucatu, SP, Brazil.
C3 Universidade Estadual Paulista; Universidade Estadual Paulista
RP Lima, GPP (corresponding author), Sao Paulo State Univ, Inst Biosci, Dept Chem & Biochem, BR-18618689 Botucatu, SP, Brazil.
EM igorminatel@hotmail.com; fabiane_vf@yahoo.com.br; ccorrea@fmb.unesp.br;
   gpplima@ibb.unesp.br
RI Francisqueti, Fabiane/AAY-8977-2020; Correa, Camila/Q-2071-2019; lima,
   giuseppina/C-5995-2012; Minatel, Igor Otavio/A-9094-2016
OI lima, giuseppina/0000-0002-1792-2605; Minatel, Igor
   Otavio/0000-0002-9922-2871; Correa, Camila Renata/0000-0001-8493-5329
FU "Conselho Nacional de Desenvolvimento Cientifico e Tecnologico" (CNPq)
   [478372/2013-2, 305177/2015-0]
FX English-language editing of this manuscript was provided by Journal
   Prep. The authors gratefully acknowledge the financial support from the
   "Conselho Nacional de Desenvolvimento Cientifico e Tecnologico" (CNPq)
   (Project No. 478372/2013-2; 305177/2015-0).
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NR 82
TC 108
Z9 112
U1 2
U2 54
PU MDPI AG
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD AUG
PY 2016
VL 17
IS 8
AR 1107
DI 10.3390/ijms17081107
PG 15
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA DU6PU
UT WOS:000382337900001
PM 27517904
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Soto-Urquieta, MG
   López-Briones, S
   Pérez-Vázquez, V
   Saavedra-Molina, A
   González-Hernández, GA
   Ramírez-Emiliano, J
AF Soto-Urquieta, Maria G.
   Lopez-Briones, Sergio
   Perez-Vazquez, Victoriano
   Saavedra-Molina, Alfredo
   Gonzalez-Hernandez, Gloria A.
   Ramirez-Emiliano, Joel
TI Curcumin restores mitochondrial functions and decreases lipid
   peroxidation in liver and kidneys of diabetic db/db mice
SO BIOLOGICAL RESEARCH
LA English
DT Article
DE Diabetes; Mitochondria; Curcumin; ATPase activity; Nitric oxide
   synthesis; Lipid oxidation
ID SKELETAL-MUSCLE MITOCHONDRIA; OXIDATIVE STRESS; NITRIC-OXIDE;
   PARKINSONS-DISEASE; METABOLIC SYNDROME; ENDOTHELIAL-CELLS;
   PHYSICAL-ACTIVITY; OBESITY; INSULIN; GLUCOSE
AB Background: Nitrosative and oxidative stress play a key role in obesity and diabetes-related mitochondrial dysfunction. The objective was to investigate the effect of curcumin treatment on state 3 and 4 oxygen consumption, nitric oxide (NO) synthesis, ATPase activity and lipid oxidation in mitochondria isolated from liver and kidneys of diabetic db/db mice.
   Results: Hyperglycaemia increased oxygen consumption and decreased NO synthesis in liver mitochondria isolated from diabetic mice relative to the control mice. In kidney mitochondria, hyperglycaemia increased state 3 oxygen consumption and thiobarbituric acid-reactive substances (TBARS) levels in diabetic mice relative to control mice. Interestingly, treating db/db mice with curcumin improved or restored these parameters to normal levels; also curcumin increased liver mitochondrial ATPase activity in db/db mice relative to untreated db/db mice.
   Conclusions: These findings suggest that hyperglycaemia modifies oxygen consumption rate, NO synthesis and increases TBARS levels in mitochondria from the liver and kidneys of diabetic mice, whereas curcumin may have a protective role against these alterations.
C1 [Soto-Urquieta, Maria G.; Lopez-Briones, Sergio; Perez-Vazquez, Victoriano; Ramirez-Emiliano, Joel] Univ Guanajuato, Dept Ciencias Med, Leon 37320, Gto, Mexico.
   [Saavedra-Molina, Alfredo] Univ Michoacana, Inst Invest Quim Biol, Morelia, Michoacan, Mexico.
   [Saavedra-Molina, Alfredo] Univ Texas Med Branch, Galveston, TX 77555 USA.
   [Gonzalez-Hernandez, Gloria A.] Univ Guanajuato, Dept Biol, Leon, Gto, Mexico.
C3 Universidad de Guanajuato; Universidad Michoacana de San Nicolas de
   Hidalgo; University of Texas System; University of Texas Medical Branch
   Galveston; Universidad de Guanajuato
RP Ramírez-Emiliano, J (corresponding author), Univ Guanajuato, Dept Ciencias Med, 20 Enero 929, Leon 37320, Gto, Mexico.
EM joelre@ugto.mx
RI Briones, Sergio/AAE-5784-2021; Saavedra-Molina, Alfredo/AAH-5607-2020;
   Perez-Vazquez, Victoriano/B-5030-2010; Ramirez-Emiliano,
   Joel/A-9022-2019
OI Perez-Vazquez, Victoriano/0000-0001-9241-9084; Lopez-Briones,
   Sergio/0000-0003-0273-0958; Ramirez-Emiliano, Joel/0000-0001-9813-9120
FU CONACYT; University of Guanajuato
FX This work was financially supported by Mexican grants from CONACYT and
   the University of Guanajuato to JRE; MGSU was a CONACYT scholar.
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NR 39
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Z9 63
U1 1
U2 27
PU SOC BIOLGIA CHILE
PI SANTIAGO
PA CASILLA 16164, SANTIAGO 9, CHILE
SN 0716-9760
EI 0717-6287
J9 BIOL RES
JI Biol. Res.
PD DEC 22
PY 2014
VL 47
AR 74
DI 10.1186/0717-6287-47-74
PG 8
WC Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics
GA AZ9JZ
UT WOS:000348531000001
PM 25723052
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Chiva-Blanch, G
   Badimon, L
   Estruch, R
AF Chiva-Blanch, G.
   Badimon, L.
   Estruch, Ramon
TI Latest Evidence of the Effects of the Mediterranean Diet in Prevention
   of Cardiovascular Disease
SO CURRENT ATHEROSCLEROSIS REPORTS
LA English
DT Article
DE Cardiovascular death; Cardiovascular disease; Diabetes; Fish; Fruits;
   Hypertension; Inflammation; Lipids; Mediterranean diet; Nuts; Obesity;
   Olive oil; Oxidative stress; Polyphenols; Risk factors; Vegetables
ID INTIMA-MEDIA THICKNESS; METABOLIC SYNDROME; RISK-FACTORS; DIABETES
   INCIDENCE; BODY-COMPOSITION; PATTERN; INFLAMMATION; METAANALYSIS;
   CHILDREN; POPULATION
AB The first step in the prevention of cardiovascular disease is healthy lifestyle and diet. Recent systematic reviews of observational studies ranked Mediterranean diet as the most likely dietary model to provide cardiovascular protection. This review updates the knowledge on the effects of Mediterranean diet from observational and randomized trials published in the last year. The results of the PREDIMED study, a randomized trial providing a higher level of scientific evidence than cohort studies, confirmed that the Mediterranean diet reduces the incidence of cardiovascular events. This effect may be exerted by reducing blood pressure; improving glucose metabolism, lipid profile, and lipoprotein particle characteristics; and decreasing inflammation and oxidative stress. It may also stem from a favorable interaction between diet and gene polymorphisms related to cardiovascular risk factors and events. These recent results allow us to recommend Mediterranean diet to subjects at high risk for cardiovascular disease with the highest level of scientific evidence.
C1 [Chiva-Blanch, G.; Badimon, L.] Cardiovasc Res Ctr CSIC ICCC, Barcelona, Spain.
   [Chiva-Blanch, G.; Badimon, L.] Biomed Res Inst St Pau IIB St Pau, Barcelona 08025, Spain.
   [Estruch, Ramon] Univ Barcelona, Dept Internal Med, Hosp Clin, IDIBAPS, E-08036 Barcelona, Spain.
   [Estruch, Ramon] CIBERobn, CIBER Fisiopatol Obesidad & Nutr CB06 03, Barcelona, Spain.
   [Estruch, Ramon] RETIC RD06 0045, Barcelona, Spain.
C3 Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Institut
   Catala de Ciencies Cardiovasculars (ICCC); University of Barcelona;
   Hospital Clinic de Barcelona; IDIBAPS; CIBER - Centro de Investigacion
   Biomedica en Red; CIBEROBN
RP Estruch, R (corresponding author), Univ Barcelona, Dept Internal Med, Hosp Clin, IDIBAPS, Villarroel 170, E-08036 Barcelona, Spain.
EM gchiva@csic-iccc.org; lbadimon@csic-iccc.org; restruch@clinic.ub.es
RI BADIMON, LINA/S-2950-2019; Estruch, Ramon/AAZ-3723-2020; Chiva-Blanch,
   Gemma/O-8072-2018; Badimon, Lina/O-4711-2014
OI Chiva-Blanch, Gemma/0000-0001-6093-0160; Badimon,
   Lina/0000-0002-9162-2459
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NR 48
TC 43
Z9 55
U1 0
U2 59
PU CURRENT MEDICINE GROUP
PI PHILADELPHIA
PA 400 MARKET STREET, STE 700, PHILADELPHIA, PA 19106 USA
SN 1523-3804
EI 1534-6242
J9 CURR ATHEROSCLER REP
JI Curr. Atheroscleros. Rep.
PD OCT
PY 2014
VL 16
IS 10
AR 446
DI 10.1007/s11883-014-0446-9
PG 7
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA AO9TB
UT WOS:000341698700006
PM 25115436
DA 2025-06-11
ER

PT J
AU Virdis, A
   Neves, MF
   Duranti, E
   Bernini, G
   Taddei, S
AF Virdis, Agostino
   Neves, Mario Fritsch
   Duranti, Emiliano
   Bernini, Giampaolo
   Taddei, Stefano
TI Microvascular Endothelial Dysfunction in Obesity and Hypertension
SO CURRENT PHARMACEUTICAL DESIGN
LA English
DT Article
DE Endothelium; obesity; nitric oxide; adipokines; inflammation
ID NITRIC-OXIDE AVAILABILITY; TUMOR-NECROSIS-FACTOR;
   CORONARY-ARTERY-DISEASE; FLOW-MEDIATED DILATION; II-INFUSED MICE;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; METABOLIC SYNDROME;
   ANGIOTENSIN-II; WEIGHT-LOSS
AB Endothelium plays a crucial role in modulating vascular function and structure, mainly by production of nitric oxide which protects the vasculature against the development of atherosclerosis and thrombosis. Traditional cardiovascular risk factors are characterized by endothelial dysfunction caused by an enhanced production of oxidative stress leading to destroy NO thus reducing its availability. A reduced endothelium-dependent relaxation is a predictor of cardiovascular events in high risk patients.
   Abdominal obesity is associated with microvascular endothelial dysfunction, through indirect mechanisms, such as insulin-resistance and the association with risk factors (including diabetes mellitus, hypertension and dyslipidemia), and directly, among others, by the production of adipokines and pro-inflammatory cytokines which in turn induce oxidative stress leading to a reduced NO availability. Several systems are amplified by the concomitant obesity and hypertension, thus generating a perpetual vicious circle which further contribute to the pathogenesis/progression of microvascular disease.
   Weight loss and modification of life-style ameliorate endothelial function in obese patients. It is conceivable that endothelial dysfunction might represent a complementary but crucial objective of a modern therapeutical approach leading to improve the prognosis in many patients, including obese patients, exposed to a high cardiovascular risk.
C1 [Virdis, Agostino; Bernini, Giampaolo; Taddei, Stefano] Univ Pisa, Dept Internal Med, I-56100 Pisa, Italy.
   [Neves, Mario Fritsch] Univ Estado Rio De Janeiro, Dept Clin Med, Rio De Janeiro, Brazil.
C3 University of Pisa; Universidade do Estado do Rio de Janeiro
RP Virdis, A (corresponding author), Univ Pisa, Dept Internal Med, Via Roma 67, I-56100 Pisa, Italy.
EM agostino.virdis@med.unipi.it
RI Taddei, Stefano/AAB-2828-2019; Virdis, Agostino/K-5315-2016
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NR 87
TC 49
Z9 58
U1 1
U2 19
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1381-6128
J9 CURR PHARM DESIGN
JI Curr. Pharm. Design
PD APR
PY 2013
VL 19
IS 13
BP 2382
EP 2389
DI 10.2174/1381612811319130006
PG 8
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 110QI
UT WOS:000316459700006
PM 23173587
DA 2025-06-11
ER

PT J
AU Chattu, VK
   Gopie, P
   Singh, RK
   Singh, K
   Singh, S
   Singh, S
   Smith, J
   Sookram, V
   Saunders, D
   Thomas, K
AF Chattu, Vijay Kumar
   Gopie, Priya
   Singh, Rajiv K.
   Singh, Kimberly
   Singh, Sachin
   Singh, Sarah
   Smith, Javanna
   Sookram, Vitra
   Saunders, DeAngello
   Thomas, Krissi
TI Investigation of the Risk Factors and Associated Co-Morbid Conditions
   among Patients with Colorectal Cancer in Trinidad
SO GASTROINTESTINAL DISORDERS
LA English
DT Article
DE colorectal cancer; hypertension; diabetes mellitus; depression; quality
   of life; Trinidad and Tobago; prevention; risk factors; alcohol;
   smoking; screening
ID METABOLIC SYNDROME; LIFE
AB Colorectal cancer (CRC) is the third most common cancer, and the fourth most common cause of cancer mortality worldwide. In Trinidad and Tobago, it is the third most common type of cancer in both sexes. Since there is scanty research on the risk factors associated with CRC, this study was conducted to determine the correlation between risk factors, including associated comorbid conditions, and CRC in Trinidad. A cross-sectional study was conducted amongst diagnosed CRC patients (>18 years) using a pre-tested questionnaire consisting of sections on demographic data, lifestyle before diagnosis, quality of life, and depression status. Additional information such as recurrence of cancer, Body Mass Index (BMI), Hypertension (HT), blood glucose levels and family history of cancer were collected from the medical records. Of the total participants, the majority were males (58%), and the mean age of diagnosis in both sexes was 65 years. The retrospective chart review showed that 68% were found to have a comorbid condition (Diabetes or HT). Upon review of the medical records, 93.2% of the subjects did not have a familial history. However, the questionnaire data showed that 73% of subjects had a family history. Around 50% of CRC patients were alcohol consumers and 30% were cigarette smokers prior to their cancer diagnosis. Interestingly, a majority of patients (91%) had never been screened for CRC prior to their diagnosis. Subjects with CRC displayed minimal depression, indicating that being diagnosed with CRC did not have a grave impact on their state of mind or quality of life. Our findings showed that prevalence of CRC was higher in males and amongst individuals of African descent. However, larger prospective studies may be warranted to fully demonstrate this effect.
C1 [Chattu, Vijay Kumar] Univ Toronto, Dept Med, Fac Med, Toronto, ON M5S 1A8, Canada.
   [Chattu, Vijay Kumar] St Michaels Hosp, Occupat Med Clin, Toronto, ON M5C 2C5, Canada.
   [Chattu, Vijay Kumar] Univ West Indies, Inst Int Relat, St Augustine, Trinidad Tobago.
   [Gopie, Priya] Eastern Reg Hlth Author, Sangre Grande Hosp, Dept Haematol Oncol, Sangre Grande, Trinidad Tobago.
   [Singh, Rajiv K.; Singh, Kimberly; Singh, Sachin; Singh, Sarah; Smith, Javanna; Sookram, Vitra; Saunders, DeAngello; Thomas, Krissi] Univ West Indies, Dept Clin Med Sci, Fac Med Sci, St Augustine, Trinidad Tobago.
C3 University of Toronto; University of Toronto; Saint Michaels Hospital
   Toronto; University West Indies Mona Jamaica; University West Indies
   Saint Augustine; University West Indies Mona Jamaica; University West
   Indies Saint Augustine
RP Chattu, VK (corresponding author), Univ Toronto, Dept Med, Fac Med, Toronto, ON M5S 1A8, Canada.; Chattu, VK (corresponding author), St Michaels Hosp, Occupat Med Clin, Toronto, ON M5C 2C5, Canada.; Chattu, VK (corresponding author), Univ West Indies, Inst Int Relat, St Augustine, Trinidad Tobago.
EM vijay.chattu@mail.utoronto.ca; pgopie.tt@gmail.com;
   Rajiv.k.singh456@gmail.com; Kimssingh09@gmail.com;
   sachisingh99@gmail.com; sarahleesingh13@gmail.com;
   Javanna.smith@my.uwi.edu; vitra.sookram@gmail.com; angsaun@gmail.com;
   Krissi2009@hotmail.com
RI ; Chattu, Vijay Kumar/C-2778-2014
OI Gopie, Priya/0000-0002-2820-5062; Chattu, Vijay
   Kumar/0000-0001-9840-8335
CR AMA, WHAT IS COL CANC
   [Anonymous], 2016, COLORECTAL CANC SCRE
   [Anonymous], COLORECTAL CANC FACT
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NR 20
TC 1
Z9 1
U1 0
U2 0
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2624-5647
J9 GASTROINTEST DISORD
JI Gastrointest. Disord.
PD SEP
PY 2020
VL 2
IS 3
BP 193
EP 201
AR 20
DI 10.3390/gidisord2030020
PG 9
WC Gastroenterology & Hepatology
WE Emerging Sources Citation Index (ESCI)
SC Gastroenterology & Hepatology
GA TE3BA
UT WOS:000669888000001
OA gold
DA 2025-06-11
ER

PT J
AU Santos, JCD
   Valentim, IB
   de Araújo, ORP
   Ataide, TD
   Goulart, MOF
AF Santos, Juliana Celia de F.
   Valentim, Iara B.
   de Araujo, Orlando R. P.
   Ataide, Terezinha da R.
   Goulart, Marilia O. F.
TI Development of Nonalcoholic Hepatopathy: Contributions of Oxidative
   Stress and Advanced Glycation End Products
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE oxidative stress; liver; AGEs; nonalcoholic fatty liver disease;
   molecular mechanism of biological activity
ID FATTY LIVER-DISEASE; INSULIN-RESISTANCE; METABOLIC SYNDROME; REACTIVE
   OXYGEN; HEPATIC STEATOSIS; DIABETIC COMPLICATIONS; ENDPRODUCTS SRAGE;
   SOLUBLE RECEPTOR; MOUSE MODELS; STEATOHEPATITIS
AB Advanced glycation end products (AGEs) are generated spontaneously in cells; however, under conditions of hyperglycemia and lipid peroxidation, their levels are higher than usual, which contribute to the development of diseases such as the nonalcoholic fatty liver disease (NAFLD). NAFLD is associated with oxidative stress (OS), which is linked to the transition of steatosis to steatohepatitis due to lipid peroxidation. The AGE-receptor interaction in hepatic stellate cells leads to an increase in reactive oxygen species and enhances the proliferation and activation of these cells, worsening liver fibrosis and disease progression. In this vicious cycle, there is production of (carboxymethyl)lysine, a biomarker for products of advanced glycation and lipid peroxidation, being a shared component between the two pathways. In this review, we aim to compile evidence to support the basic molecular mechanisms of AGEs and OS generation and their influence, independently or combined, on the evolution of NAFLD. The deeper understanding of the interrelations of AGEs + OS may help to elucidate the pathogenic pathways of NAFLD and to devise rational therapeutic interventions for this disease, with an expected positive impact on quality of life of patients.
C1 [Santos, Juliana Celia de F.; Valentim, Iara B.; de Araujo, Orlando R. P.; Goulart, Marilia O. F.] Fed Univ Alagoas IQB UFAL, Inst Chem & Biotechnol, BR-57072900 Maceio, Alagoas, Brazil.
   [Valentim, Iara B.] Fed Inst Educ Sci & Technol Alagoas, BR-57020600 Maceio, Alagoas, Brazil.
   [Ataide, Terezinha da R.] Fed Univ Alagoas FANUT UFAL, Fac Nutr, BR-57072970 Maceio, Alagoas, Brazil.
   [Goulart, Marilia O. F.] Fed Univ Alagoas UFAL, Northeast Biotechnol Network RENORBIO, BR-57072900 Maceio, Alagoas, Brazil.
RP Goulart, MOF (corresponding author), Fed Univ Alagoas IQB UFAL, Inst Chem & Biotechnol, BR-57072900 Maceio, Alagoas, Brazil.
EM jcfsnut@hotmail.com; ibvalentim@yahoo.com.br; orlando_rpa@hotmail.com;
   terezinhadarochaataide@gmail.com; mariliaofg@gmail.com
RI ; GOULART, MARILIA OF/A-1199-2013
OI DE ARAUJO, ORLANDO ROBERTO/0000-0003-4189-6520; GOULART, MARILIA
   OF/0000-0001-9860-3667
FU CAPES; CNPq [Universal 479825/2009-2]; PRONEX/FAPEAL/CNPq;
   INCT/Bioanalitica
FX The authors thank CAPES, CNPq (Universal 479825/2009-2)
   PRONEX/FAPEAL/CNPq and INCT/Bioanalitica for providing fellowships and
   grant funding.
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NR 60
TC 56
Z9 57
U1 0
U2 34
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD OCT
PY 2013
VL 14
IS 10
BP 19846
EP 19866
DI 10.3390/ijms141019846
PG 21
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 274QK
UT WOS:000328620900030
PM 24084729
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Kelly, SJ
   Stedman, J
   Leonardi-Bee, J
AF Kelly, SJ
   Stedman, J
   Leonardi-Bee, J
TI Is hemoglobin Alc level associated with measures of socio-economic
   status in non-diabetics after controlling for known explanatory factors?
SO STRESS AND HEALTH
LA English
DT Article
DE blood glucose; hemoglobin A; glycosylated; health surveys; stress;
   social class
ID GLYCOSYLATED HEMOGLOBIN; GLYCATED HEMOGLOBIN; JOB STRAIN; STRESS;
   HEALTH; WOMEN; INDICATOR; HBA(1C); MEN
AB Objective: Glycosylated hemoglobin (GHb) is a well-validated measure of control in diabetics but fasting glucose levels account for only a portion of the variance in non-diabetics. Stress has been suggested as a factor driving socio-economic inequalities in health and GHb appears to be elevated in stressed populations. This project examined the relationship between GHb levels and measures of socio-economic status (SES) in non-diabetics.
   Methods: Data were used from 1828 individuals in the National Health and Nutrition Examination Survey (NHANES) 1999-2000 dataset with fasting glucose samples and GHb levels (HbA1c) < 7.5 per cent. The effect of adding individual measures of SES to the models after controlling for explanatory factors was assessed.
   Results: Associations were found, in non-diabetics, between HbA1c levels and measures of SES after controlling for fasting glucose level, age and weekly alcohol consumption in both men and women. For men, serum insulin also contributed to the models.
   Conclusion: SES was found to have graded relationships with HbA1c and relatively small or nonexistent associations with other metabolic syndrome factors. HbA1c levels were significantly associated with three measures of social status in women and four measures in men. Copyright (c) 2005 John Wiley & Sons, Ltd.
C1 Univ Nottingham, Queens Med Ctr, Div Epidemiol & Publ Hlth, Nottingham NG7 2RD, England.
   Univ Nottingham, Sch Med, Nottingham NG7 2RD, England.
C3 University of Nottingham; University of Nottingham
RP Kelly, SJ (corresponding author), Univ Nottingham, Queens Med Ctr, Div Epidemiol & Publ Hlth, Nottingham NG7 2RD, England.
EM shona.kelly@nottingham.ac.uk
RI Kelly, Shona/D-1815-2010
OI Kelly, Shona/0000-0003-4002-048X; Leonardi-Bee, Jo/0000-0003-0893-6068
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NR 29
TC 9
Z9 10
U1 0
U2 6
PU JOHN WILEY & SONS INC
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 1532-3005
J9 STRESS HEALTH
JI Stress Health
PD AUG
PY 2005
VL 21
IS 3
BP 185
EP 192
DI 10.1002/smi.1052
PG 8
WC Psychology, Applied; Psychiatry; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA 956YL
UT WOS:000231336000006
DA 2025-06-11
ER

PT J
AU Dempsey, B
   da Silva, BP
   Cruz, LC
   Vileigas, D
   Silva, ARM
   da Silva, RP
   Meotti, FC
AF Dempsey, Bianca
   da Silva, Beatriz Pereira
   Cruz, Litiele Cezar
   Vileigas, Danielle
   Silva, Amanda R. M.
   da Silva, Railmara Pereira
   Meotti, Flavia Carla
TI Unraveling the effects of uric acid on endothelial cells: A global
   proteomic study
SO REDOX BIOLOGY
LA English
DT Article
DE Uric acid; Proteomics; HUVEC; Endothelial cell damage; PXDN;
   Inflammation
ID MOLECULAR PHYSIOLOGY; URATE HYDROPEROXIDE; METABOLIC SYNDROME; ADHESION
   MOLECULE; OXIDATIVE STRESS; KIDNEY-DISEASE; ANTIOXIDANT; HYPERURICEMIA;
   PROOXIDANT; OXIDASE
AB This work aims to understand how normouricemic levels of uric acid can induce endothelial dysfunction seeking global proteomic alterations in Human Umbilical Vein cells (HUVEC). It reveals significant alterations in redoxsensitive and antioxidant proteins, chaperones, and proteins associated with cell migration and adhesion in response to uric acid exposure. Monitoring cellular oxidation with the roGFP2-Grx1 probe proved increased oxidation levels induced by uric acid, which can be attenuated by peroxidasin (PXDN) inhibition, suggesting a regulatory role for PXDN in mitigating oxidative stress induced by uric acid. As a consequence of uric acid oxidation and the formation of reactive intermediate, we identified adducts in proteins (+140 kDa) in a novel post-translation modification named uratylation. Increased misfolded protein levels and p62 aggregation were also found, indicating disturbances in cellular proteostasis. Furthermore, uric acid promoted monocyte adhesion and upregulated ICAM and VCAM protein levels, implicating a pro-inflammatory response in endothelial cells. These findings provide critical insights into the molecular mechanisms underlying vascular damage associated with uric acid.
C1 [Dempsey, Bianca; da Silva, Beatriz Pereira; Cruz, Litiele Cezar; Vileigas, Danielle; Silva, Amanda R. M.; da Silva, Railmara Pereira; Meotti, Flavia Carla] Univ Sao Paulo, Dept Biochem, Inst Chem, Sao Paulo, Brazil.
C3 Universidade de Sao Paulo
RP Meotti, FC (corresponding author), Univ Sao Paulo, Dept Biochem, Inst Chem, Sao Paulo, Brazil.
EM flaviam@iq.usp.br
RI Cruz, Litiele/P-5614-2015; Meotti, Flavia/AAS-8804-2021; Dempsey,
   Bianca/LFR-5896-2024
OI Cruz, Litiele/0000-0002-6724-7812; Meotti, Flavia/0000-0002-7217-3352
FU Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
   [2013/07937-8, 2018/14898-2]; FAPESP [2012/12663-1, 2023/00995-4];
   University of Sao Paulo (FAPESP) [2013/07937-8, 2012/12663-1,
   2023/00995-4]; Vinnova [2023-00995] Funding Source: Vinnova
FX This study was supported by Fundacao de Amparo a Pesquisa do Estado de
   Sao Paulo (FAPESP) : CEPID Redoxoma 2013/07937-8; Young Investigator-2,
   grant number 2018/14898-2. B.D., B.P.S., D.V., A.P.S., and R.P.S.
   received a scholarship from FAPESP. Proteomic analysis was performed at
   the Redox Proteomics Core of the Mass Spectrometry Resource at Chemistry
   Institute, University of Sao Paulo (FAPESP grant numbers 2012/12663-1,
   CEPID Redoxoma 2013/07937-8; 2023/00995-4) led by Prof. Graziella Eliza
   Ronsein and Prof. Paolo Di Mascio.
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NR 105
TC 0
Z9 0
U1 1
U2 1
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2213-2317
J9 REDOX BIOL
JI Redox Biol.
PD MAY
PY 2025
VL 82
AR 103625
DI 10.1016/j.redox.2025.103625
PG 21
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 1MS8V
UT WOS:001468701400001
PM 40203480
OA gold
DA 2025-06-11
ER

PT J
AU Chen, Y
   Qie, XJ
   Quan, W
   Zeng, MM
   Qin, F
   Chen, J
   Adhikari, B
   He, ZY
AF Chen, Yao
   Qie, Xuejiao
   Quan, Wei
   Zeng, Maomao
   Qin, Fang
   Chen, Jie
   Adhikari, Benu
   He, Zhiyong
TI Omnifarious fruit polyphenols: an omnipotent strategy to prevent and
   intervene diabetes and related complication?
SO CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
LA English
DT Review
DE Anti-diabetic mechanisms; diabetes mellitus; fruit polyphenols;
   hyperglycemia; signal pathway
ID NF-KAPPA-B; ENDOPLASMIC-RETICULUM STRESS; HIGH-FAT DIET; INHIBIT
   ALPHA-GLUCOSIDASE; TYROSINE-PHOSPHATASE 1B; SASKATOON BERRY POWDER;
   PANCREATIC BETA-CELLS; GLYCEMIC LOAD VALUES; OXIDATIVE STRESS;
   INSULIN-RESISTANCE
AB Diabetes mellitus is a metabolic syndrome which cannot be cured. Recently, considerable interest has been focused on food ingredients to prevent and intervene in complications of diabetes. Polyphenolic compounds are one of the bioactive phytochemical constituents with various biological activities, which have drawn increasing interest in human health. Fruits are part of the polyphenol sources in daily food consumption. Fruit-derived polyphenols possess the anti-diabetic activity that has already been proved either from in vitro studies or in vivo studies. The mechanisms of fruit polyphenols in treating diabetes and related complications are under discussion. This is a comprehensive review on polyphenols from the edible parts of fruits, including those from citrus, berries, apples, cherries, mangoes, mangosteens, pomegranates, and other fruits regarding their potential benefits in preventing and treating diabetes mellitus. The signal pathways of characteristic polyphenols derived from fruits in reducing high blood glucose and intervening hyperglycemia-induced diabetic complications were summarized.
C1 [Chen, Yao; Qie, Xuejiao; Quan, Wei; Zeng, Maomao; Qin, Fang; Chen, Jie; He, Zhiyong] Jiangnan Univ, State Key Lab Food Sci & Technol, Wuxi, Jiangsu, Peoples R China.
   [Chen, Yao; Qie, Xuejiao; Quan, Wei; Zeng, Maomao; Qin, Fang; Chen, Jie; He, Zhiyong] Jiangnan Univ, Int Joint Lab Food Safety, Wuxi, Jiangsu, Peoples R China.
   [Adhikari, Benu] RMIT Univ, Sch Sci, Melbourne, Vic, Australia.
C3 Jiangnan University; Jiangnan University; Royal Melbourne Institute of
   Technology (RMIT)
RP He, ZY (corresponding author), Jiangnan Univ, State Key Lab Food Sci & Technol, Wuxi, Jiangsu, Peoples R China.; He, ZY (corresponding author), Jiangnan Univ, Int Joint Lab Food Safety, Wuxi, Jiangsu, Peoples R China.; Adhikari, B (corresponding author), RMIT Univ, Sch Sci, Melbourne, Vic, Australia.
EM benu.adhikari@rmit.edu.au; zyhe@jiangnan.edu.cn
RI Zeng, Maomao/M-1422-2013; xuejiao, qie/HZM-0601-2023; Chen,
   Jiaxuan/G-3752-2011; He, Zhiyong/ABE-6427-2020; Adhikari,
   Benu/K-6192-2017
OI Adhikari, Benu/0000-0002-7571-7968
FU National Natural Science Foundation of China [31771978]; Six Talent
   Peaks Projec in Jiangsu Province [NY-095]; National First-class
   Discipline Program of Food Science and Technology [JUFSTR20180201];
   Innovation and Exploration Fund of State Key Laboratory of Food Science
   and Technology, Jiangnan University [SKLF-ZZB-202102]; Fundamental
   Research Funds for the Central Universities [JUSRP21802]
FX This review was supported by the National Natural Science Foundation of
   China under Grant number 31771978, the Six Talent Peaks Projec in
   Jiangsu Province Grant number NY-095, the National First-class
   Discipline Program of Food Science and Technology Grant number
   JUFSTR20180201, the Innovation and Exploration Fund of State Key
   Laboratory of Food Science and Technology, Jiangnan University Grant
   number SKLF-ZZB-202102, and the Fundamental Research Funds for the
   Central Universities Grant number JUSRP21802.
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NR 437
TC 8
Z9 8
U1 4
U2 62
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1040-8398
EI 1549-7852
J9 CRIT REV FOOD SCI
JI Crit. Rev. Food Sci. Nutr.
PD AUG 7
PY 2023
VL 63
IS 20
BP 4288
EP 4324
DI 10.1080/10408398.2021.2000932
EA NOV 2021
PG 37
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA M4DS7
UT WOS:000720204900001
PM 34792409
DA 2025-06-11
ER

PT J
AU Tappia, PS
   Adameova, A
   Dhalla, NS
AF Tappia, Paramjit S.
   Adameova, Adriana
   Dhalla, Naranjan S.
TI Attenuation of Diabetes-induced Cardiac and Subcellular Defects by
   Sulphur-containing Amino Acids
SO CURRENT MEDICINAL CHEMISTRY
LA English
DT Review
DE Sulphur-containing amino acids; Taurine; Cysteine; Diabetes mellitus;
   Diabetic cardiomyopathy; Preventive nutrition
ID L-CYSTEINE SUPPLEMENTATION; II-INDUCED HYPERTROPHY; NA+-K+-ATPASE;
   RENIN-ANGIOTENSIN; N-ACETYLCYSTEINE; TAURINE SUPPLEMENTATION; CALCIUM
   PARADOX; PLATELET-AGGREGATION; ANTIOXIDANT ACTIVITY; INTRACELLULAR CA2+
AB Background: Patients with diabetes mellitus have an increased risk of mortality due to cardiovascular complications. Supplementation with specific sulphur-containing amino acids is rapidly emerging as a possible therapeutic adjuvant for diabetes and associated cardiovascular complications.
   Observations: It is well-known that oxidative stress plays an important role in the pathogenesis of diabetes-induced cardiovascular disease, which is invariably associated with abnormal blood lipid profile, insulin resistance and other symptoms of metabolic syndrome. Cysteine and taurine are among the most common sulphur-containing amino acids and their cellular levels decline during diabetes that may contribute to the development of the cardiomyopathy. Although sulphur-containing agents exert multiple actions on cellular and subcellular functions in the heart, they also exhibit antioxidant properties and thus may exert beneficial effects in different pathophysiological conditions.
   Conclusion: It is concluded that reduction of oxidative stress by cysteine and taurine may serve as an important mechanism for the attenuation of diabetes-induced subcellular and functional abnormalities in the heart.
C1 [Tappia, Paramjit S.] St Boniface Gen Hosp, Asper Clin Res Inst, Winnipeg, MB, Canada.
   [Adameova, Adriana] Comenius Univ, Fac Pharm, Dept Pharmacol & Toxicol, Bratislava, Slovakia.
   [Dhalla, Naranjan S.] Univ Manitoba, Max Rady Coll Med, Rady Fac Hlth Sci, Inst Cardiovasc Sci,Dept Physiol Pathophysiol, Winnipeg, MB, Canada.
C3 University of Manitoba; Children's Hospital Research Institute of
   Manitoba; Saint Boniface Hospital; Comenius University Bratislava;
   University of Manitoba
RP Tappia, PS (corresponding author), Asper Clin Re search Inst, CR3129-369 Tache Ave, Winnipeg, MB R2H 2A6, Canada.
EM ptappia@sbrc.ca
RI adameova, adriana/HZK-8075-2023; Dhalla, Naranjan/C-8279-2014
FU Slovak Scientific Grant Agency (VEGA) [1/0638/12, APVV-15-0607,
   APVV-15-0119]
FX None of the authors have any disclosures or conflict of interest. The
   research reported in this article was supported by a grant from the
   Slovak Scientific Grant Agency (VEGA) 1/0638/12 and APVV-15-0607,
   APVV-15-0119 (AA).
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NR 113
TC 13
Z9 13
U1 0
U2 17
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 0929-8673
EI 1875-533X
J9 CURR MED CHEM
JI Curr. Med. Chem.
PY 2018
VL 25
IS 3
BP 336
EP 345
DI 10.2174/0929867324666170705115207
PG 10
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Pharmacology &
   Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
GA FU0DE
UT WOS:000423520800003
PM 28685680
DA 2025-06-11
ER

PT J
AU Yamagishi, S
   Matsui, T
   Ueda, S
   Fukami, K
   Okuda, S
AF Yamagishi, Sho-ichi
   Matsui, Takanori
   Ueda, Seiji
   Fukami, Kei
   Okuda, Seiya
TI Clinical Utility of Acarbose, an α-Glucosidase Inhibitor in
   Cardiometabolic Disorders
SO CURRENT DRUG METABOLISM
LA English
DT Review
DE Acarbose; diabetes; insulin resistance; oxidative stress; postprandial
   hyperglycemia
ID TYPE-2 DIABETIC-PATIENTS; INTIMA-MEDIA THICKNESS;
   CORONARY-HEART-DISEASE; MONOCYTE CHEMOATTRACTANT PROTEIN-1; PROMISING
   THERAPEUTIC STRATEGY; POSTPRANDIAL PLASMA-GLUCOSE;
   LOW-DENSITY-LIPOPROTEIN; OXIDATIVE STRESS; ENDOTHELIAL DYSFUNCTION;
   CARDIOVASCULAR-DISEASE
AB Diabetes is associated with an increase risk for cardiovascular disease (CVD). Recently, macrovascular complications of diabetes have been shown to start before the development of diabetes. Indeed, several clinical studies have confirmed the increased risk of CVD in patients with impaired glucose tolerance (IGT). Since postprandial hyperglycemia and insulin resistance are thought to play a central role in the development and progression of CVD in patients with IGT, amelioration of postprandial hyperglycemia as well as insulin resistance is a therapeutic target for the prevention of CVD in these high-risk patients. Acarbose, an alpha-glucosidase inhibitor, delays the absorption of carbohydrate from the small intestine, thereby reducing postprandial hyperglycemia. Further, recently, acarbose has been shown to improve insulin resistance in vivo. These findings suggest that acarbose is a promising metabolic modifier that could reduce the risk of CVD in patients with the metabolic syndrome. In this paper, we review the clinical utility of acarbose in various cardiometabolic disorders.
C1 [Yamagishi, Sho-ichi; Matsui, Takanori] Kurume Univ, Sch Med, Dept Pathophysiol & Therapeut Diabet Vasc Complic, Kurume, Fukuoka 8300011, Japan.
   [Ueda, Seiji; Fukami, Kei; Okuda, Seiya] Kurume Univ, Sch Med, Dept Med, Div Nephrol, Kurume, Fukuoka 8300011, Japan.
C3 Kurume University; Kurume University
RP Yamagishi, S (corresponding author), Kurume Univ, Sch Med, Dept Pathophysiol & Therapeut Diabet Vasc Complic, Kurume, Fukuoka 8300011, Japan.
EM shoichi@med.kurume-u.ac.jp
OI Matsui, Takanori/0000-0001-9506-7571
FU Ministry of Education, Culture, Sports, Science and Technology, Japan
FX This work was supported in part by Grants of Collaboration with Venture
   Companies Project from the Ministry of Education, Culture, Sports,
   Science and Technology, Japan (S.Y.).
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NR 65
TC 44
Z9 50
U1 2
U2 21
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1389-2002
EI 1875-5453
J9 CURR DRUG METAB
JI Curr. Drug Metab.
PD FEB
PY 2009
VL 10
IS 2
BP 159
EP 163
DI 10.2174/138920009787522133
PG 5
WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
GA 440DF
UT WOS:000265678600006
PM 19275550
DA 2025-06-11
ER

PT J
AU Michael, OS
   Bamidele, O
   Ogheneovo, P
   Ariyo, TA
   Adedayo, LD
   Oluranti, OI
   Soladoye, EO
   Adetunji, CO
   Awobajo, FO
AF Michael, Olugbenga S.
   Bamidele, Olubayode
   Ogheneovo, Pamela
   Ariyo, Temitope A.
   Adedayo, Lawrence D.
   Oluranti, Olufemi I.
   Soladoye, Elizabeth O.
   Adetunji, Charles O.
   Awobajo, Funmileyi O.
TI Watermelon rind ethanol extract exhibits hepato-renal protection against
   lead induced-impaired antioxidant defenses in male Wistar rats
SO CURRENT RESEARCH IN PHYSIOLOGY
LA English
DT Article
DE Watermelon; Uric acid; Nitric oxide; Oxidative stress; Lead acetate
ID URIC-ACID; OXIDATIVE STRESS; METABOLIC SYNDROME; SERUM; RISK;
   ASSOCIATION; EXPOSURE; DISEASE; QUALITY; ACETATE
AB Lead acetate associated tissue injury has been linked to altered antioxidant defenses, hyperuricemia and inflammation. We hypothesized that watermelon rind extract, would ameliorate lead acetate-induced hepatorenal injury. Thirty Male Wistar rats received distilled water, lead acetate (Pb; 5 mg/kg) with or without watermelon rind extract (WM; 400 mg/kg; WM + Pb; 15 days of WM pretreatment); Pb + WM (15 days of WM post treatment) and simultaneous treatment (WM-Pb) for 30 days. Lead toxicity led to elevated serum malondialdehyde, creatinine, urea, uric acid, lactate dehydrogenase, liver injury enzymes, as well as decreased body weight. Decreased serum levels of reduced glutathione, nitric oxide, total protein and glutathione peroxidase activity was also observed. However, these alterations were ameliorated by watermelon rind extract in lead acetate-treated rats. Watermelon rind ethanol extract protects against lead acetate-induced hepato-renal injury through improved antioxidant defenses at least in part, via uric acid/nitric oxide-dependent pathway signifying the health benefits of this agricultural waste and a potential for waste recycling while limiting environmental pollution.
C1 [Michael, Olugbenga S.] Bowen Univ, Dept Physiol, Cardiometab Res Unit, Iwo, Nigeria.
   [Bamidele, Olubayode; Ogheneovo, Pamela; Ariyo, Temitope A.; Adedayo, Lawrence D.; Oluranti, Olufemi I.] Bowen Univ, Coll Hlth Sci, Dept Physiol, Iwo, Nigeria.
   [Soladoye, Elizabeth O.] Nebraska Inst Forens Sci, Lincoln, NE USA.
   [Adetunji, Charles O.] Edo Univ, Dept Microbiol, Microbiol Biotechnol & Nanotechnol Lab, Iyamho, Edo State, Nigeria.
   [Awobajo, Funmileyi O.] Univ Lagos, Coll Med, Dept Physiol, Lagos, Nigeria.
   [Michael, Olugbenga S.] Bowen Univ, Dept Physiol, PMB 284, Iwo, Nigeria.
C3 University of Lagos
RP Michael, OS (corresponding author), Bowen Univ, Dept Physiol, PMB 284, Iwo, Nigeria.
EM michaelolugbenga2@gmail.com
RI Michael, Olugbenga/ABH-4359-2020; Adedayo, Lawrence/HWP-6081-2023;
   Awobajo, Funmileyi/AAU-4733-2021; Bamidele, Olubayode/ADA-2849-2022
OI Oluranti, Olufemi/0000-0001-8894-3254; BAMIDELE,
   OLUBAYODE/0000-0002-8591-034X; Michael, Olugbenga/0000-0001-8119-4043
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NR 41
TC 3
Z9 3
U1 0
U2 3
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2665-9441
J9 CURR RES PHYSIOL
JI Curr. Res. Physiol.
PY 2021
VL 4
BP 252
EP 259
DI 10.1016/j.crphys.2021.11.002
PG 8
WC Physiology
WE Emerging Sources Citation Index (ESCI)
SC Physiology
GA Z0GH6
UT WOS:001108949500002
PM 34841269
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Dou, Y
   Xin, JL
   Zhou, P
   Tang, JM
   Xie, HL
   Fan, WT
   Zhang, Z
   Wu, DL
AF Dou, Yang
   Xin, Jinglei
   Zhou, Peng
   Tang, Jianming
   Xie, Hongliang
   Fan, Wanting
   Zhang, Zheng
   Wu, Donglei
TI Bidirectional association between polycystic ovary syndrome and
   periodontal diseases
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Review
DE polycystic ovary syndrome; periodontal diseases; host immune;
   inflammation; oral micro biota
ID SEX STEROID-HORMONES; INSULIN-RESISTANCE; METABOLIC SYNDROME; CASE
   DEFINITIONS; BUTYRIC-ACID; HEALTH; SUSCEPTIBILITY; INFLAMMATION;
   MICROBIOME; TESTOSTERONE
AB Polycystic ovary syndrome (PCOS) and periodontal disease (PDD) share common risk factors. The bidirectional interaction between PCOS and PDD has been reported, but until now, the underlying molecular mechanisms remain unclear. Endocrine disorders including hyperandrogenism (HA) and insulin resistance (IR) in PCOS disturb the oral microbial composition and increase the abundance of periodontal pathogens. Additionally, PCOS has a detrimental effect on the periodontal supportive tissues, including gingiva, periodontal ligament, and alveolar bone. Systemic low-grade inflammation status, especially obesity, persistent immune imbalance, and oxidative stress induced by PCOS exacerbate the progression of PDD. Simultaneously, PDD might increase the risk of PCOS through disturbing the gut microbiota composition and inducing low-grade inflammation and oxidative stress. In addition, genetic or epigenetic predisposition and lower socioeconomic status are the common risk factors for both diseases. In this review, we will present the latest evidence of the bidirectional association between PCOS and PDD from epidemiological, mechanistic, and interventional studies. A deep understanding on their bidirectional association will be beneficial to provide novel strategies for the treatment of PCOS and PDD.
C1 [Dou, Yang] Jinan Univ, Shenzhen Baoan Womens & Childrens Hosp, Dept Stomatol, Shenzhen, Guangdong, Peoples R China.
   [Xin, Jinglei; Zhou, Peng] Guangdong Women & Children Hosp, Dept Stomatol, Guangzhou, Guangdong, Peoples R China.
   [Tang, Jianming; Xie, Hongliang; Fan, Wanting; Zhang, Zheng; Wu, Donglei] Shenzhen Peoples Hosp, Dept Stomatol, Shenzhen, Guangdong, Peoples R China.
C3 Jinan University; Jinan University
RP Wu, DL (corresponding author), Shenzhen Peoples Hosp, Dept Stomatol, Shenzhen, Guangdong, Peoples R China.
EM wu1582224766@163.com
OI Wu, Donglei/0000-0003-0529-5744
FU Medical Science and Technology Research Foundation of Guangdong Province
   [B2021053]; Shenzhen People's Hospital for young and middle-aged Co-PI
   foster project [SYJCYJ202105]
FX Funding This study was funded by the Medical Science and Technology
   Research Foundation of Guangdong Province (No. B2021053) and Shenzhen
   People's Hospital for young and middle-aged Co-PI foster project
   (SYJCYJ202105).
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NR 108
TC 10
Z9 10
U1 2
U2 17
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD JAN 23
PY 2023
VL 14
AR 1008675
DI 10.3389/fendo.2023.1008675
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 8M7FH
UT WOS:000924625400001
PM 36755917
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Singh, AK
   Yadav, D
   Sharma, N
   Jin, JO
AF Singh, Anand-Krishna
   Yadav, Dhananjay
   Sharma, Neha
   Jin, Jun-O
TI Dipeptidyl Peptidase (DPP)-IV Inhibitors with Antioxidant Potential
   Isolated from Natural Sources: A Novel Approach for the Management of
   Diabetes
SO PHARMACEUTICALS
LA English
DT Review
DE dipeptidyl peptidase-IV; glucagon-like peptide-1; hyperglycemia;
   incretin; antioxidant
ID IV DPP-IV; IN-VITRO; OXIDATIVE STRESS; METABOLIC SYNDROME;
   FREE-RADICALS; SEED EXTRACT; PROTEIN; GLP-1; IDENTIFICATION;
   VILDAGLIPTIN
AB Type 2 diabetes mellitus (T2DM) is characterized by hyperglycemia that is predominantly caused by insulin resistance or impaired insulin secretion, along with disturbances in carbohydrate, fat and protein metabolism. Various therapeutic approaches have been used to treat diabetes, including improvement of insulin sensitivity, inhibition of gluconeogenesis, and decreasing glucose absorption from the intestines. Recently, a novel approach has emerged using dipeptidyl peptidase-IV (DPP-IV) inhibitors as a possible agent for the treatment of T2DM without producing any side effects, such as hypoglycemia and exhaustion of pancreatic beta-cells. DPP-IV inhibitors improve hyperglycemic conditions by stabilizing the postprandial level of gut hormones such as glucagon-like peptide-1, and glucose-dependent insulinotropic polypeptides, which function as incretins to help upregulate insulin secretion and beta-cell mass. In this review, we summarized DPP-IV inhibitors and their mechanism of inhibition, activities of those isolated from various natural sources, and their capacity to overcome oxidative stress in disease conditions.
C1 [Singh, Anand-Krishna] Shri Vaishnav Vidyapeeth Vishwavidyalaya, Shri Vaishnav Inst Sci, Indore 453555, Madhya Pradesh, India.
   [Yadav, Dhananjay; Jin, Jun-O] Yeungnam Univ, Dept Med Biotechnol, Gyongsan 38541, South Korea.
   [Sharma, Neha] Devi Ahilya Univ, Sch Life Sci, Indore 452001, Madhya Pradesh, India.
   [Jin, Jun-O] Yeungnam Univ, Res Inst Cell Culture, Gyongsan 38541, South Korea.
C3 Yeungnam University; Devi Ahilya University; Yeungnam University
RP Singh, AK (corresponding author), Shri Vaishnav Vidyapeeth Vishwavidyalaya, Shri Vaishnav Inst Sci, Indore 453555, Madhya Pradesh, India.; Jin, JO (corresponding author), Yeungnam Univ, Dept Med Biotechnol, Gyongsan 38541, South Korea.; Jin, JO (corresponding author), Yeungnam Univ, Res Inst Cell Culture, Gyongsan 38541, South Korea.
EM akssingh5@gmail.com; dhanyaday16481@gmail.com; nehasharma.908@gmail.com;
   jinjo@yu.ac.kr
RI Yadav, Dhananjay/AAZ-9435-2021; Jin, Jun-O/AAH-2727-2020; Sharma,
   Neha/HPH-6624-2023; Jin, Jun-O/G-2998-2014
OI singh, anand-krishna/0000-0002-3619-3292; Jin, Jun-O/0000-0003-4216-8111
FU Korea Institute of Planning and Evaluation for Technology in Food,
   Agriculture, Forestry (IPET) through High Value-added Food Technology
   Development Program - Ministry of Agriculture, Food and Rural Affairs
   (MAFRA) [321026-05]; National Research Foundation of Korea
   [NRF-2019R1G1A1008566]
FX This work was supported by Korea Institute of Planning and Evaluation
   for Technology in Food, Agriculture, Forestry (IPET) through High
   Value-added Food Technology Development Program, funded by Ministry of
   Agriculture, Food and Rural Affairs (MAFRA) (321026-05) and the National
   Research Foundation of Korea (NRF-2019R1G1A1008566).
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NR 110
TC 54
Z9 55
U1 1
U2 25
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1424-8247
J9 PHARMACEUTICALS-BASE
JI Pharmaceuticals
PD JUN
PY 2021
VL 14
IS 6
AR 586
DI 10.3390/ph14060586
PG 16
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA SZ0BY
UT WOS:000666243400001
PM 34207217
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Kehler, DS
   Stammers, AN
   Susser, SE
   Hamm, NC
   Kimber, DE
   Hlynsky, MW
   Duhamel, TA
AF Kehler, D. Scott
   Stammers, Andrew N.
   Susser, Shanel E.
   Hamm, Naomi C.
   Kimber, Dustin E.
   Hlynsky, Michael W.
   Duhamel, Todd A.
TI Cardiovascular complications of type 2 diabetes in youth
SO BIOCHEMISTRY AND CELL BIOLOGY
LA English
DT Review
DE type 2 diabetes mellitus; youth; cardiovascular disease;
   pathophysiology; clinical trials
ID INTIMA-MEDIA THICKNESS; LIFE-STYLE INTERVENTION; NECROSIS-FACTOR-ALPHA;
   INSULIN-RESISTANCE; BLOOD-PRESSURE; OXIDATIVE STRESS; DNA METHYLATION;
   RISK-FACTORS; METABOLIC SYNDROME; OBESE ADOLESCENTS
AB The prevalence of type 2 diabetes mellitus (T2DM) in youth has increased dramatically over the past decades. The literature also suggests that the progression from an impaired glucose tolerance state to established T2DM is more rapid in youth, compared to adults. The presence of significant cardiovascular complications in youth with T2DM, including cardiac, macrovascular, and microvascular remodeling, is another major issue in this younger cohort and poses a significant threat to the healthcare system. However, this issue is only now emerging as a major public health concern, with few data to support optimal treatment targets and strategies to reduce cardiovascular disease (CVD) risk in youth with T2DM. Accordingly, the purpose of this minireview is to better understand the cardiovascular complications in youth with T2DM. We briefly describe the pathophysiology from youth studies, including oxidative stress, inflammation, renin-angiotensin aldosterone system, and epigenetics, which link T2DM and CVD. We also describe the literature concerning the early signs of CVD in youth and potential treatment options to reduce cardiovascular risk.
C1 [Kehler, D. Scott; Stammers, Andrew N.; Hamm, Naomi C.; Kimber, Dustin E.; Hlynsky, Michael W.] Univ Manitoba, Leisure & Human Performance Res Inst, Fac Kinesiol & Recreat Management, Inst Cardiovasc Sci,St Boniface Hosp Res Ctr,Hlth, Winnipeg, MB R3T 2N2, Canada.
   [Susser, Shanel E.] Univ Manitoba, Dept Physiol, St Boniface Hosp Res Ctr, Inst Cardiovasc Sci, Winnipeg, MB R3T 2N2, Canada.
   [Duhamel, Todd A.] Univ Manitoba, Fac Kinesiol & Recreat Management, Leisure & Human Performance Res Inst, Hlth, Winnipeg, MB R3T 2N2, Canada.
   [Duhamel, Todd A.] Univ Manitoba, Dept Physiol, St Boniface Hosp Res Ctr, Inst Cardiovasc Sci, Winnipeg, MB R3T 2N2, Canada.
   [Duhamel, Todd A.] Manitoba Inst Child Hlth, Winnipeg, MB, Canada.
C3 University of Manitoba; Children's Hospital Research Institute of
   Manitoba; Saint Boniface Hospital; University of Manitoba; Saint
   Boniface Hospital; Children's Hospital Research Institute of Manitoba;
   University of Manitoba; University of Manitoba; Saint Boniface Hospital;
   Children's Hospital Research Institute of Manitoba
RP Duhamel, TA (corresponding author), Univ Manitoba, Max Bell Ctr 317, Winnipeg, MB R3T 2N2, Canada.
EM tduhamel@sbrc.ca
RI Duhamel, Todd/ABA-9623-2020; Duhamel, Todd/F-4433-2017
OI Kehler, Scott/0000-0002-2154-2306; Duhamel, Todd/0000-0001-8467-4800
FU Canadian Institutes of Health Research (CIHR); Heart and Stroke
   Foundation; Manitoba Health Research Council (MHRC); MHRC Studentship;
   CIHR Strategic Training Initiative in Health Research (STIHR) Knowledge
   Translation Canada Student Fellowship; CIHR STIHR Population
   Intervention for Chronic Disease Prevention Fellowship; Heart and Stroke
   Foundation Dr. Dexter Harvey Award; CIHR Canada Graduate Scholarship
FX TAD holds operating grants from the Canadian Institutes of Health
   Research (CIHR) and the Heart and Stroke Foundation. We have no
   conflicts of interest to disclose. TAD was supported by a Manitoba
   Health Research Council (MHRC) Establishment Grant. DSK was supported by
   an MHRC Studentship, a CIHR Strategic Training Initiative in Health
   Research (STIHR) Knowledge Translation Canada Student Fellowship, a CIHR
   STIHR Population Intervention for Chronic Disease Prevention Fellowship
   and the Heart and Stroke Foundation Dr. Dexter Harvey Award. ANS was
   supported by a CIHR Canada Graduate Scholarship.
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NR 174
TC 3
Z9 4
U1 2
U2 18
PU CANADIAN SCIENCE PUBLISHING
PI OTTAWA
PA 123 Slater Street, Suite 610, OTTAWA, ON K1P 5H2, CANADA
SN 0829-8211
EI 1208-6002
J9 BIOCHEM CELL BIOL
JI Biochem. Cell Biol.
PD OCT
PY 2015
VL 93
IS 5
BP 496
EP 510
DI 10.1139/bcb-2014-0118
PG 15
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA CS6HK
UT WOS:000362179000010
PM 25629355
DA 2025-06-11
ER

PT J
AU Yelisyeyeva, O
   Semen, K
   Zarkovic, N
   Kaminskyy, D
   Lutsyk, O
   Rybalchenko, V
AF Yelisyeyeva, Olha
   Semen, Khrystyna
   Zarkovic, Neven
   Kaminskyy, Danylo
   Lutsyk, Olexander
   Rybalchenko, Volodymyr
TI Activation of aerobic metabolism by Amaranth oil improves heart rate
   variability both in athletes and patients with type 2 diabetes mellitus
SO ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
LA English
DT Article
DE Amaranth oil; aerobic metabolism; heart rate variability; correlations;
   metabolic syndrome; type 2 diabetes mellitus; athletes; hormesis;
   oxidative stress correction
ID NATURAL PROTECTIVE MECHANISM; OXIDATIVE STRESS; GASTRIC-MUCOSA;
   FATTY-ACIDS; HYPERGLYCEMIA; MITOCHONDRIA; ANTIOXIDANTS; PROTEINS;
   DISEASE; HEALTH
AB The aim of present research was to study the effects of Amaranth oil (AmO) supplementation on aerobic metabolism and heart rate variability (HRV) in type 2 diabetes mellitus patients and in athletes. Several parameters of aerobic metabolism and HRV were assessed. Supplementation with AmO caused mild pro-oxidant activity resulting in improved uptake of oxidative destruction products and modulation of catalase and SOD activity with subsequent development of an antioxidant effect. These findings were very distinct in athletes but less pronounced in diabetics. Redistribution of haemoglobin ligands in athletes indicates involvement of haemoproteins in free radical reactions during AmO supplementation. Improvement in HRV by daily consumption of AmO as observed in both study groups suggested increased production of endogenous oxygen and enhancement of the cardio-respiratory function. The advantage of activation of aerobic metabolism in OS-related disorders resulting in improved self-organization of the living system and hormetic reaction mechanisms are discussed.
C1 [Yelisyeyeva, Olha] Danylo Halystky Lviv Natl Med Univ, Dept Histol Cytol & Embryol, Lvov, Ukraine.
   [Zarkovic, Neven] Rudjer Boskovic Inst, Zagreb, Croatia.
   [Rybalchenko, Volodymyr] Taras Shevchenko Natl Univ Kyiv, Kiev, Ukraine.
C3 Danylo Halytsky Lviv National Medical University; Rudjer Boskovic
   Institute; Ministry of Education & Science of Ukraine; Taras Shevchenko
   National University of Kyiv
RP Yelisyeyeva, O (corresponding author), Danylo Halystky Lviv Natl Med Univ, Dept Histol Cytol & Embryol, Lvov, Ukraine.
EM yelisol@gmail.com
RI Rybalchenko, Taras/ISV-0111-2023; Kaminskyy, Danylo/A-3670-2015;
   Zarkovic, Neven/AAG-5836-2019; Yelisyeyeva, Olha/E-7685-2019
OI Rybalchenko, Volodymyr/0000-0001-5069-2621; Lutsyk,
   Alexander/0000-0001-6819-804X; Kaminskyy, Danylo/0000-0001-6837-367X;
   Zarkovic, Neven/0000-0001-5032-0369; Yelisyeyeva,
   Olha/0000-0002-9003-4532
FU COST Action [B35]
FX This article would not appear without the initiative and keen interest
   of the late Professor Janos Feher, who supported our scientific concept
   of oxidative stress correction and made us think about its implication
   in metabolic syndrome. We also have to mention an important role of our
   teacher Professor Mykhaylo Tymochko, who left us valuable scientific
   acquirement in the field of free radical and oxygen homeostasis and died
   too early under tragic circumstances. This research is dedicated to
   them. The study was supported by COST B35 Action.
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NR 71
TC 23
Z9 25
U1 0
U2 9
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1381-3455
EI 1744-4160
J9 ARCH PHYSIOL BIOCHEM
JI Arch. Physiol. Biochem.
PD MAY
PY 2012
VL 118
IS 2
BP 47
EP 57
DI 10.3109/13813455.2012.659259
PG 11
WC Biochemistry & Molecular Biology; Biophysics; Endocrinology &
   Metabolism; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Endocrinology &
   Metabolism; Physiology
GA 936QX
UT WOS:000303606200002
PM 22393897
DA 2025-06-11
ER

PT J
AU Labbé, A
   Garand, C
   Cogger, VC
   Paquet, ER
   Desbiens, M
   Le Couteur, DG
   Lebel, M
AF Labbe, Adam
   Garand, Chantal
   Cogger, Victoria C.
   Paquet, Eric R.
   Desbiens, Myriam
   Le Couteur, David G.
   Lebel, Michel
TI Resveratrol Improves Insulin Resistance Hyperglycemia and
   Hepatosteatosis But Not Hypertriglyceridemia, Inflammation, and Life
   Span in a Mouse Model for Werner Syndrome
SO JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL
   SCIENCES
LA English
DT Article
DE Resveratrol; Metabolism; Werner syndrome; Mouse model; Microarrays
ID ACTIVATED PROTEIN-KINASE; SYNDROME HELICASE; OXIDATIVE STRESS; SYNDROME
   GENE; HOMOLOGOUS RECOMBINATION; DIETARY RESTRICTION; METABOLIC SYNDROME;
   AGED MICE; WRN; DNA
AB Werner syndrome is a premature aging disorder caused by mutations in a RecQ-like DNA helicase. Mice lacking the helicase domain of the WRN homologue exhibit many features of Werner syndrome, including a pro-oxidant status and a shorter mean life span. Here, we show that resveratrol supplementation improved the hyperglycemia and the insulin resistance phenotype in these Writ mutant mice. In addition, resveratrol reversed liver steatosis, lipid peroxidaton, and the defenestration phenotypes observed in such mice. Resveratrol, however, did not improve the hypertriglyceridemia, inflammatory stress, nor extend the mean life span of these mutant mice. Microarray and biologic pathway enrichment analyses on liver tissues revealed that resveratrol mainly decreased lipidogenesis and increased genes involved in the insulin signaling pathway and the glutathione metabolism in Writ mutant mice. Finally, resveratrol-treated mutant mice exhibited an increase in the frequency of lymphoma and of several solid tumors. These results indicate that resveratrol supplementation might exert at least metabolic benefits for Werner syndrome patients.
C1 [Labbe, Adam; Garand, Chantal; Paquet, Eric R.; Desbiens, Myriam; Lebel, Michel] Univ Laval, Hop Hotel Dieu Quebec, Ctr Rech Cancerol, Dept Mol Biol Med Biochem & Pathol, Quebec City, PQ G1R 2J6, Canada.
   [Cogger, Victoria C.; Le Couteur, David G.] Univ Sydney, Ctr Educ & Res Ageing, Sydney, NSW 2006, Australia.
   [Cogger, Victoria C.; Le Couteur, David G.] Univ Sydney, ANZAC Res Inst, Sydney, NSW 2006, Australia.
   [Cogger, Victoria C.; Le Couteur, David G.] Concord RG Hosp, Sydney, NSW, Australia.
C3 Laval University; Laval University Hospital; University of Sydney;
   University of Sydney; ANZAC Research Institute; Concord Repatriation
   General Hospital
RP Lebel, M (corresponding author), Univ Laval, Hop Hotel Dieu Quebec, Ctr Rech Cancerol, Dept Mol Biol Med Biochem & Pathol, 9 McMahon St, Quebec City, PQ G1R 2J6, Canada.
EM michel.lebel@crhdq.ulaval.ca
OI Le Couteur, David/0000-0002-4227-5817; Paquet, Eric/0000-0001-9194-1655;
   Garand, Chantal/0000-0003-0716-6487
FU Canadian Institutes of Health Research; National Sciences and
   Engineering Research Council of Canada; National Health and Medical
   Research Council of Australia; Ageing and Alzheimer's Research
   Foundation (a Division of the Medical Foundation of the University of
   Sydney); Ramaciotti Foundation
FX This work was supported in part by grants from the Canadian Institutes
   of Health Research and from the National Sciences and Engineering
   Research Council of Canada to M.L. and the National Health and Medical
   Research Council of Australia, the Ageing and Alzheimer's Research
   Foundation (a Division of the Medical Foundation of the University of
   Sydney), and Ramaciotti Foundation to D.G.L.C. and V.C.C. M.L. is a
   senior scholar of the Fonds de la Recherche en Sante du Quebec.
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U1 0
U2 5
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1079-5006
EI 1758-535X
J9 J GERONTOL A-BIOL
JI J. Gerontol. Ser. A-Biol. Sci. Med. Sci.
PD MAR
PY 2011
VL 66
IS 3
BP 264
EP 278
DI 10.1093/gerona/glq184
PG 15
WC Geriatrics & Gerontology; Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA 735LK
UT WOS:000288415800003
PM 20974729
DA 2025-06-11
ER

PT J
AU Yang, Z
   Wang, L
AF Yang, Zhen
   Wang, Lin
TI Current, emerging, and potential therapies for non-alcoholic
   steatohepatitis
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Review
DE non-alcoholic fatty liver disease; lipid peroxidation; non-alcoholic
   steatohepatitis; metabolic homeostasis; ferroptosis; targeted
   therapeutics; the gut microbiome
ID FATTY LIVER-DISEASE; FARNESOID-X-RECEPTOR; COA CARBOXYLASE INHIBITION;
   ENDOPLASMIC-RETICULUM STRESS; REDUCES HEPATIC STEATOSIS;
   PLACEBO-CONTROLLED TRIAL; MESENCHYMAL STEM-CELLS; PPAR-ALPHA; VITAMIN-E;
   INSULIN SENSITIVITY
AB Non-alcoholic fatty liver disease (NAFLD) has been identified as the most common chronic liver disease worldwide, with a growing incidence. NAFLD is considered the hepatic manifestation of a metabolic syndrome that emerges from multiple factors (e.g., oxidative stress, metabolic disorders, endoplasmic reticulum stress, cell death, and inflammation). Non-alcoholic steatohepatitis (NASH), an advanced form of NAFLD, has been reported to be a leading cause of cirrhosis and hepatic carcinoma, and it is progressing rapidly. Since there is no approved pharmacotherapy for NASH, a considerable number of therapeutic targets have emerged with the deepening of the research on NASH pathogenesis. In this study, the therapeutic potential and properties of regulating metabolism, the gut microbiome, antioxidant, microRNA, inhibiting apoptosis, targeting ferroptosis, and stem cell-based therapy in NASH are reviewed and evaluated. Since the single-drug treatment of NASH is affected by individual heterogeneous responses and side effects, it is imperative to precisely carry out targeted therapy with low toxicity. Lastly, targeted therapeutic agent delivery based on exosomes is proposed in this study, such that drugs with different mechanisms can be incorporated to generate high-efficiency and low-toxicity individualized medicine.
C1 [Yang, Zhen; Wang, Lin] Fourth Mil Med Univ, Xi Jing Hosp, Dept Hepatobiliary Surg, Xian, Peoples R China.
C3 Air Force Medical University
RP Wang, L (corresponding author), Fourth Mil Med Univ, Xi Jing Hosp, Dept Hepatobiliary Surg, Xian, Peoples R China.
EM fierywang@163.com
RI Yang, Zhen/HPB-9390-2023
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NR 231
TC 15
Z9 16
U1 6
U2 30
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD MAR 30
PY 2023
VL 14
AR 1152042
DI 10.3389/fphar.2023.1152042
PG 15
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA D7FV6
UT WOS:000970356800001
PM 37063264
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Mansouri, T
   Ghanatios, G
   Hatzinger, L
   Barich, R
   Dampha, E
   Temple, JL
   Clemency, BM
   Hostler, D
AF Mansouri, Tegan
   Ghanatios, George
   Hatzinger, Lori
   Barich, Rachel
   Dampha, Ebriama
   Temple, Jennifer L.
   Clemency, Brian M.
   Hostler, David
TI Eating Patterns among Emergency Medical Service Providers in the United
   States: A Qualitative Interview Study
SO NUTRIENTS
LA English
DT Article
DE emergency medical services; EMS; eating patterns; nutrition; paramedics;
   nutrition related disease
ID CARDIOVASCULAR-DISEASE; PARTICIPATORY RESEARCH; POSTTRAUMATIC-STRESS;
   CIRCADIAN-RHYTHMS; PHYSICAL-ACTIVITY; RISK-FACTORS; DIETARY; RESPONSES;
   OBESITY; FOOD
AB Emergency medical service (EMS) providers experience demanding work conditions in addition to shift work, which increases risk for nutrition related chronic disease such as metabolic syndrome, diabetes, obesity, and cardiovascular disease. The high stress, emergent, and unpredictable nature of EMS may interfere with healthy eating patterns on and off shift, however little is known about how these conditions impact dietary patterns among EMS providers. This study aimed to understand factors impacting dietary patterns through semi-structured interviews with 40 EMS providers throughout the United States. Interviews were conducted virtually via Zoom video conference. Inductive coding was used to identify themes throughout the interviews. Salient factors mentioned in the interviews included hunger, fatigue, stress, coworker influence, ambulance posting, geographical location, agency policy, and culture. Factors were grouped into 4 domains: physiological factors, psychosocial factors, physical environment, and organizational environment, represented by an adapted version of the social ecological model of health behaviors to include factors influencing eating patterns specific to EMS, which may contribute to overall health. Various barriers to healthy eating exist within EMS, and future studies should explore interventions at each level of our proposed model to improve conditions and reduce nutrition related disease risk in this essential population.
C1 [Mansouri, Tegan; Ghanatios, George; Hatzinger, Lori; Barich, Rachel; Dampha, Ebriama; Temple, Jennifer L.; Clemency, Brian M.; Hostler, David] SUNY Buffalo, Dept Exercise & Nutr Sci, Buffalo, NY 14214 USA.
   [Hatzinger, Lori] Univ Southern Calif, Dept Populat & Publ Hlth Sci, Los Angeles, CA 90007 USA.
   [Barich, Rachel] Univ Prince Edward Isl, Dept Foods & Nutr, Charlottetown, PE C1A 4P3, Canada.
   [Clemency, Brian M.; Hostler, David] SUNY Buffalo, Dept Emergency Med, Buffalo, NY 14203 USA.
C3 State University of New York (SUNY) System; University at Buffalo, SUNY;
   University of Southern California; University of Prince Edward Island;
   State University of New York (SUNY) System; University at Buffalo, SUNY
RP Mansouri, T (corresponding author), SUNY Buffalo, Dept Exercise & Nutr Sci, Buffalo, NY 14214 USA.
EM teganman@buffalo.edu
OI Hatzinger, Lori/0000-0003-3247-2136
CR Al-Hammad F.A., 2012, MIDDLE E J NURS, V6, P14
   [Anonymous], JOB DESCRIPTION NEW
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NR 52
TC 2
Z9 2
U1 1
U2 8
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD NOV
PY 2022
VL 14
IS 22
AR 4884
DI 10.3390/nu14224884
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 6K6NE
UT WOS:000887615400001
PM 36432571
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Gonzales, GB
   Njunge, JM
   Gichuki, BM
   Wen, BJ
   Potani, I
   Voskuijl, W
   Bandsma, RHJ
   Berkley, JA
AF Gonzales, Gerard Bryan
   Njunge, James M.
   Gichuki, Bonface M.
   Wen, Bijun
   Potani, Isabel
   Voskuijl, Wieger
   Bandsma, Robert H. J.
   Berkley, James A.
TI Plasma proteomics reveals markers of metabolic stress in HIV infected
   children with severe acute malnutrition
SO SCIENTIFIC REPORTS
LA English
DT Article
ID MALNOURISHED CHILDREN; CARDIOVASCULAR RISK; LOW-INCOME; MANAGEMENT;
   COMPLEMENT; MORTALITY; FAT; BUTYRYLCHOLINESTERASE; REGULARIZATION;
   EXPRESSION
AB HIV infection affects up to 30% of children presenting with severe acute malnutrition (SAM) in Africa and is associated with increased mortality. Children with SAM are treated similarly regardless of HIV status, although mechanisms of nutritional recovery in HIV and/or SAM are not well understood. We performed a secondary analysis of a clinical trial and plasma proteomics data among children with complicated SAM in Kenya and Malawi. Compared to children with SAM without HIV (n=113), HIV-infected children (n=54) had evidence (false discovery rate (FDR) corrected p<0.05) of metabolic stress, including enriched pathways related to inflammation and lipid metabolism. Moreover, we observed reduced plasma levels of zinc-<alpha>-2-glycoprotein, butyrylcholinesterase, and increased levels of complement C2 resembling findings in metabolic syndrome, diabetes and other non-communicable diseases. HIV was also associated (FDR corrected p<0.05) with higher plasma levels of inflammatory chemokines. Considering evidence of biomarkers of metabolic stress, it is of potential concern that our current treatment strategy for SAM regardless of HIV status involves a high-fat therapeutic diet. The results of this study suggest a need for clinical trials of therapeutic foods that meet the specific metabolic needs of children with HIV and SAM.
C1 [Gonzales, Gerard Bryan] Univ Ghent, Fac Med & Hlth Sci, Dept Gastroenterol, Ghent, Belgium.
   [Gonzales, Gerard Bryan] VIB Inflammat Res Ctr, Ghent, Belgium.
   [Njunge, James M.; Gichuki, Bonface M.; Potani, Isabel; Voskuijl, Wieger; Bandsma, Robert H. J.; Berkley, James A.] Childhood Acute Illness & Nutr CHAIN Network, Nairobi, Kenya.
   [Njunge, James M.; Gichuki, Bonface M.; Berkley, James A.] KEMRI Wellcome Trust Res Programme, Kilifi, Kenya.
   [Wen, Bijun; Bandsma, Robert H. J.] Hosp Sick Children, Ctr Global Child Hlth, Toronto, ON, Canada.
   [Wen, Bijun; Bandsma, Robert H. J.] Univ Toronto, Fac Med, Dept Nutr Sci, Toronto, ON, Canada.
   [Voskuijl, Wieger] Univ Amsterdam, Emma Childrens Hosp, Global Child Hlth Grp, Med Ctr, Amsterdam, Netherlands.
   [Voskuijl, Wieger] Univ Amsterdam, Amsterdam Inst Global Hlth & Dev, Dept Global Hlth, Med Ctr, Amsterdam, Netherlands.
   [Berkley, James A.] Univ Oxford, Ctr Trop Med & Global Hlth, Nuffield Dept Med, Oxford, England.
C3 Ghent University; Flanders Institute for Biotechnology (VIB); University
   of Toronto; Hospital for Sick Children (SickKids); University of
   Toronto; Emma Children's Hospital; University of Amsterdam; University
   of Amsterdam; University of Oxford
RP Gonzales, GB (corresponding author), Univ Ghent, Fac Med & Hlth Sci, Dept Gastroenterol, Ghent, Belgium.; Gonzales, GB (corresponding author), VIB Inflammat Res Ctr, Ghent, Belgium.
EM Gerard.gonzales@ugent.be
RI Potani, Isabel/LRU-3404-2024; Gichuki, Bonface/HCH-1557-2022
OI Bandsma, Robert/0000-0001-6358-4750; Gonzales, Gerard
   Bryan/0000-0001-6614-3520; Gichuki, Bonface M./0000-0001-8766-7470;
   Potani, Isabel/0000-0002-3494-534X
FU Thrasher Fund [9403]; Ghent University-VLIR-UOS Global Minds Fund; Bill
   & Melinda Gates Foundation within the Childhood Acute Illness and
   Nutrition (CHAIN) Network [OPP1131320]; MRC/DfID/Wellcome Trust Joint
   Global Health Trials scheme [MR/M007367/1]; MRC [MR/M007367/1] Funding
   Source: UKRI
FX The original clinical trial was supported by the Thrasher Fund (Grant
   number: 9403), awarded to JAB. GBG is a postdoctoral fellow of the
   Research Foundation-Flanders (FWO). The Ghent University-VLIR-UOS Global
   Minds Fund supported the travel of GBG to Kenya. JAB and JMN are
   currently supported by the Bill & Melinda Gates Foundation within the
   Childhood Acute Illness and Nutrition (CHAIN) Network (Grant
   OPP1131320). JAB is currently supported by the MRC/DfID/Wellcome Trust
   Joint Global Health Trials scheme (Grant MR/M007367/1). The funders had
   no role in the design, conduct, analysis, or writing of this manuscript.
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NR 61
TC 7
Z9 7
U1 0
U2 8
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD JUL 8
PY 2020
VL 10
IS 1
DI 10.1038/s41598-020-68143-7
PG 11
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA MJ7XC
UT WOS:000548301200017
PM 32641735
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Codoñer-Franch, P
   Alonso-Iglesias, E
AF Codoner-Franch, Pilar
   Alonso-Iglesias, Eulalia
TI Resistin: Insulin resistance to malignancy
SO CLINICA CHIMICA ACTA
LA English
DT Review
DE Adipocytokines; Atherosclerosis; Cancer; Inflammation; Obesity; Resistin
ID INCREASES LIPID-ACCUMULATION; ENDOPLASMIC-RETICULUM STRESS;
   LINKED-IMMUNOSORBENT-ASSAY; TYPE-2 DIABETES-MELLITUS; INCREASED SERUM
   RESISTIN; BODY-MASS INDEX; ADIPOSE-TISSUE; OXIDATIVE STRESS; METABOLIC
   SYNDROME; LINKING OBESITY
AB Adipose tissue is recognized as an endocrine organ that secretes bioactive substances known as adipokines. Excess adipose tissue and adipose tissue dysfunction lead to dysregulated adipokine production that can contribute to the development of obesity-related co-morbidities. Among the various adipokines, resistin, which was initially considered as a determinant of the emergence of insulin resistance in obesity, has appeared as an important link between obesity and inflammatory processes. Several experimental and clinical studies have suggested an association between increased resistin levels and severe conditions associated with obesity such as cardiovascular disease and malignancies. In this review, we present the growing body of evidence that human resistin is an inflammatory biomarker and potential mediator of obesity-associated diseases. A common pathway seems to involve the combined alteration of immune and inflammatory processes that favor metabolic disturbances, atherosclerosis and carcinogenesis. The mode of action and the signaling pathways utilized by resistin in its interactions with target cells could involve oxidative and nitrosative stress. Therefore, resistin could function as a key molecule in the complications of obesity development and could potentially be used as a diagnostic and prognostic marker. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Codoner-Franch, Pilar] Dr Peset Univ Hosp, Dept Pediat, Valencia 46017, Spain.
   [Codoner-Franch, Pilar] Univ Valencia, Dept Pediat Obstet & Gynecol, Valencia 46010, Spain.
   [Alonso-Iglesias, Eulalia] Univ Valencia, Dept Biochem & Mol Biol, Valencia 46010, Spain.
C3 University of Valencia; University of Valencia
RP Codoñer-Franch, P (corresponding author), Dr Peset Univ Hosp, Dept Pediat, Ave Gaspar Aguilar 90, Valencia 46017, Spain.
EM pilar.codoner@uv.es
RI /L-9758-2014; Codoner-Franch, Pilar/K-9333-2014
OI Codoner-Franch, Pilar/0000-0002-1549-1573
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NR 149
TC 124
Z9 131
U1 0
U2 28
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0009-8981
EI 1873-3492
J9 CLIN CHIM ACTA
JI Clin. Chim. Acta
PD JAN 1
PY 2015
VL 438
BP 46
EP 54
DI 10.1016/j.cca.2014.07.043
PG 9
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA AX0AT
UT WOS:000346616800009
PM 25128719
DA 2025-06-11
ER

PT J
AU Farah, R
   Shurtz-Swirski, R
   Dorlechter, F
AF Farah, R.
   Shurtz-Swirski, R.
   Dorlechter, F.
TI Primed polymorphonuclear leukocytes constitute a possible link between
   inflammation and oxidative stress in hyperlipidemic patients: effect of
   statins
SO MINERVA CARDIOANGIOLOGICA
LA English
DT Article
DE Apoptosis; Hyperlipidemias; Inflammation; Oxidative stress; Simvastatin
AB Aim. Oxidative stress (OS) and inflammation and are among the mechanisms that have been recently implicated in pathogenesis of hyperlipidemia. Peripheral polymorphonuclear leukocytes (PMNLs) are primed in metabolic syndrome patients, which include hyperlipidemic patients, releasing uncontrolled superoxide contributing to OS and inflammation. Recent studies have attributed additional anti-ischemic and antioxidative characteristics to the antihyperlipidemic antiatherogenic drug, simvastatin. The aim of this paper was to evaluate the possible non-traditional effect of five months' simvastatin treatment on PMNL priming and inflammation in hyperlipidemia.
   Methods. Thirty non-smoking hyperlipidemic patients were treated for 5 months with Simvastatin and compared with age and gender-matched healthy controls (HC). PMNL priming was assessed by the rate of superoxide release from separated, phorbol ester-stimulated PMNLs and by PMNL-CD11b levels. Inflammation was reflected by blood albumin, transferrin, C-reactive protein (CRP) and fibrinogen levels, white blood cells (WBC), PMNL counts and by PMNL apoptosis.
   Results. Five months of simvastatin treatment showed a decrease in lipid levels, concomitantly with reduction in PMNL priming, PMNL apoptosis, fibrinogen and CRP levels.
   Conclusion. PMNLs are primed in hyperlipidemic patients contributing to OS and inflammation in these patients. Treating these patients with Simvastatin may be beneficial due to its combined anti-PMNL priming and anti-inflammatory effects, in addition to its traditional antiatherogenic characteristics.
C1 [Farah, R.] Western Galilee Hosp, Dept Internal Med F, Nahariyya, Israel.
   [Shurtz-Swirski, R.; Dorlechter, F.] Western Galilee Hosp, Eliachar Res Lab, Nahariyya, Israel.
C3 Western Galilee Hospital; Western Galilee Hospital
RP Farah, R (corresponding author), Ziv Med Ctr, Dept Internal Med B, Safed, Israel.
EM raymond.f@ziv.health.gov.il
RI Farah, Randa/Q-3200-2019
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NR 15
TC 9
Z9 9
U1 0
U2 1
PU EDIZIONI MINERVA MEDICA
PI TURIN
PA CORSO BRAMANTE 83-85 INT JOURNALS DEPT., 10126 TURIN, ITALY
SN 0026-4725
J9 MINERVA CARDIOANGIOL
JI Minerva Cardioangiol.
PD APR
PY 2010
VL 58
IS 2
BP 175
EP 181
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA V28CS
UT WOS:000208659500003
PM 20440247
DA 2025-06-11
ER

PT J
AU Taylor, JSW
   Williams, SRP
   Rhys, R
   James, P
   Frenneaux, MP
AF Taylor, JSW
   Williams, SRP
   Rhys, R
   James, P
   Frenneaux, MP
TI Conjugated linoleic acid impairs endothelial function
SO ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
LA English
DT Article
DE body composition; conjugated linoleic acid; endothelial function;
   obesity; oxidative stress
ID ABDOMINAL ADIPOSE-TISSUE; BODY-COMPOSITION; INSULIN SENSITIVITY;
   CARDIOVASCULAR RISK; METABOLIC SYNDROME; OXIDATIVE STRESS; SERUM LEPTIN;
   FATTY-ACIDS; LIFE-STYLE; SUPPLEMENTATION
AB Objectives - To determine the effect of dietary supplementation with conjugated linoleic acid (CLA) on body mass index (BMI), body fat distribution, endothelial function, and markers of cardiovascular risk.
   Methods and Results - Forty healthy volunteers with BMI > 27 kg/m(2) were randomized to receive a CLA isomeric mixture or olive oil in a 12-week double-blind study. Subcutaneous body fat and abdominal/hepatic fat content were assessed using skin-fold thicknesses and computed tomography scanning, respectively. Endothelial function was assessed by brachial artery flow-mediated dilatation (FMD). Plasma isoprostanes were measured as an index of oxidative stress. CLA supplementation did not result in a significant change in BMI index or total body fat. There was a significant decrease in limb (-7.8 mm, P < 0.001), but not torso skin-fold thicknesses or abdominal or liver fat content. Brachial artery FMD declined (-1.3%, P=0.013), and plasma F2-isoprostanes increased (+91pg/ mL, P=0.042).
   Conclusions - A CLA isomeric mixture had at most modest effects on adiposity and worsened endothelial function. On the basis of these results, the use of the isomeric mixture of CLA as an aid to weight loss cannot be recommended.
C1 Morriston Hosp, Dept Cardiol, Swansea SA6 6NL, W Glam, Wales.
   Univ Glamorgan, Pontypridd CF37 1DL, M Glam, Wales.
   Royal Glamorgan Hosp, Llantrisant, Wales.
   Wales Heart Res Inst, Cardiff, Wales.
   Univ Birmingham, Dept Cardiovasc Med, Birmingham, W Midlands, England.
C3 Morriston Hospital; University of South Wales; Cardiff University;
   University of Birmingham
RP Morriston Hosp, Dept Cardiol, Swansea SA6 6NL, W Glam, Wales.
EM jswt@totalise.co.uk
OI Williams, Simon/0000-0002-7442-7395; James, Philip/0000-0001-5254-0250
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NR 55
TC 79
Z9 84
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1079-5642
EI 1524-4636
J9 ARTERIOSCL THROM VAS
JI Arterioscler. Thromb. Vasc. Biol.
PD FEB
PY 2006
VL 26
IS 2
BP 307
EP 312
DI 10.1161/01.ATV.0000199679.40501.ac
PG 6
WC Hematology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Hematology; Cardiovascular System & Cardiology
GA 004GQ
UT WOS:000234740400013
PM 16339498
OA Bronze, Green Submitted
DA 2025-06-11
ER

PT J
AU Jukic, T
   Ihan, A
   Strojnik, V
   Stubljar, D
   Starc, A
AF Jukic, Tomislav
   Ihan, Alojz
   Strojnik, Vojko
   Stubljar, David
   Starc, Andrej
TI The effect of active occupational stress management on psychosocial and
   physiological wellbeing: a pilot study
SO BMC MEDICAL INFORMATICS AND DECISION MAKING
LA English
DT Article
DE 24alife; E-tools; Healthcare applications; Occupational health;
   Prevention
ID METABOLIC SYNDROME; INTERVENTION; PREVENTION; EXERCISE; WORK; RISK
AB Background The aim of the study was to address the working population with an occupational stress prevention program using mHealth solution and encourage them for healthy lifestyle choices. Methods Seventeen participants were randomized from the corporate setting. A 24alife app with a good compliance program was selected. Test battery has been designed to test the physical readiness, psychological evaluation and biological blood markers for stress. Participants were followed up after 30, 60 and 90 days, respectively, within the intervention period. Weight of participants was tracked three times per month. Univariate analysis compared the continuous variables by One-Way Repeated-Measures ANOVA test when the data were normally distributed, or Wilcoxon rank sum test for abnormal distribution of variables. Results Participants used the app with a compliance rate of 94.1%. The psychological evaluation revealed higher motivation for work, lower burnout scores and participants gave subjective responses of better general wellbeing. Some of the participants lost up to four kg of body mass. Physical readiness has also improved. Conclusions Results of mHealth projects on corporate could include primary health care institutions and health ministry to extend the existing system to patients' pockets where they can monitor their disease and increase the ability of self-care.
C1 [Jukic, Tomislav] Fac Med Josip Juraj Strossmayer Osijek, Dept Internal Med Family Med & Hist Med, Osijek, Croatia.
   [Ihan, Alojz] Univ Ljubljana Fac Med, Inst Microbiol & Immunol, Ljubljana, Slovenia.
   [Strojnik, Vojko] Univ Ljubljana, Fac Sport, Ljubljana, Slovenia.
   [Stubljar, David] In Med, Dept Res & Dev, Mestni Trg 11, Metlika 8330, Slovenia.
   [Starc, Andrej] Univ Ljubljana, Chair Publ Hlth, Fac Hlth Sci, Ljubljana, Slovenia.
C3 University of Ljubljana; University of Ljubljana; University of
   Ljubljana
RP Stubljar, D (corresponding author), In Med, Dept Res & Dev, Mestni Trg 11, Metlika 8330, Slovenia.
EM d.stubljar@gmail.com
RI Starc, Andrej/M-9918-2019
OI Stubljar, David/0000-0002-9653-9830; Starc, Andrej/0000-0002-2128-7974;
   Ihan, Alojz/0000-0003-2904-1212
FU company RC IKTS Zalec from Slovenia
FX The execution of the study was supported by the company RC IKTS Zalec
   from Slovenia, which developed a 24alife mobile application.
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NR 50
TC 5
Z9 8
U1 2
U2 14
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1472-6947
J9 BMC MED INFORM DECIS
JI BMC Med. Inform. Decis. Mak.
PD DEC 3
PY 2020
VL 20
IS 1
AR 321
DI 10.1186/s12911-020-01347-z
PG 8
WC Medical Informatics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Informatics
GA PB5WP
UT WOS:000596391300002
PM 33272279
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Sánchez-Aceves, LM
   Dublán-García, O
   López-Martínez, LX
   Novoa-Luna, KA
   Islas-Flores, H
   Galar-Martínez, M
   García-Medina, S
   Hernández-Navarro, MD
   Gómez-Oliván, LM
AF Mireya Sanchez-Aceves, Livier
   Dublan-Garcia, Octavio
   Lopez-Martinez, Leticia-Xochitl
   Adriana Novoa-Luna, Karen
   Islas-Flores, Hariz
   Galar-Martinez, Marcela
   Garcia-Medina, Sandra
   Dolores Hernandez-Navarro, Maria
   Manuel Gomez-Olivan, Leobardo
TI Reduction of the Oxidative Stress Status Using Steviol Glycosides in a
   Fish Model (Cyprinus carpio)
SO BIOMED RESEARCH INTERNATIONAL
LA English
DT Article
ID ANTIOXIDANT ENZYME-ACTIVITIES; ARTIFICIAL SWEETENERS;
   LIPID-PEROXIDATION; METABOLIC SYNDROME; FREE-RADICALS; LIVER-INJURY;
   RISK; BIOMARKERS; CONSUMPTION; REBAUDIANA
AB Steviol glycosides are sweetening compounds from the Stevia rebaudiana Bertoni plant. This product is considered safe for human consumption and was approved as a food additive by the Food and Drugs Administration (FDA) and European Food Safety Authority (EFSA). Its effects on the ecosystemhave not been studied in depth; therefore, it is necessary to carry out ecotoxicological studies in organisms such as Cyprinus carpio. The present study aimed to evaluate the antioxidant activity by SGs on diverse tissues in C. carpio using oxidative stress (OS) biomarkers. To test the antioxidant activity, carps were exposed to four systems: (1) SGs free control, (2) CCl4 0.5 mL/kg, (3) SGs 1 g/L, and (4) CCl4 0.5 mL/kg + SGs 1 g/L at 96 h. The following biomarkers were analyzed: lipoperoxidation (LPX), hydroperoxide content (HPC), and protein carbonyl content (PCC), as well as antioxidant activity of superoxide dismutase (SOD) and catalase (CAT). It was found that both (3 and 4) systems' exposure decreases LPX, CHP, PCC, SOD, and CAT with respect to the CCl4 system. The results of this study demonstrate that the concentrations of SGs used are not capable of generating oxidative stress and, on the contrary, would appear to induce an antioxidant effect.
C1 [Mireya Sanchez-Aceves, Livier; Dublan-Garcia, Octavio; Adriana Novoa-Luna, Karen; Islas-Flores, Hariz; Dolores Hernandez-Navarro, Maria; Manuel Gomez-Olivan, Leobardo] Univ Autonoma Estado Mexico, Fac Quim, Lab Toxicol Ambiental, Paseo Colon Intersecc Paseo Tollocan S-N, Toluca 50120, Mex, Mexico.
   [Lopez-Martinez, Leticia-Xochitl] Ctr Invest Alimentac & Desarrollo AC, Unidad Culiacan, Carretera El Dorado Km 5-5, Culiacan 80110, Sin, Mexico.
   [Galar-Martinez, Marcela; Garcia-Medina, Sandra] Inst Politecn Nacl, Escuela Nacl Ciencias Biol, Dept Farm, Lab Toxicol Acuat,Unidad Profes Adolfo Lopez Mate, Av Wilfrido Massieu Esq Cda Miguel Stampa S-N, Ciudad De Mexico 07738, Mexico.
C3 CIAD - Centro de Investigacion en Alimentacion y Desarrollo; Instituto
   Politecnico Nacional - Mexico
RP Gómez-Oliván, LM (corresponding author), Univ Autonoma Estado Mexico, Fac Quim, Lab Toxicol Ambiental, Paseo Colon Intersecc Paseo Tollocan S-N, Toluca 50120, Mex, Mexico.
EM lmgomezo@uaemex.mx
RI Gómez-Oliván, Leobardo/AAM-8619-2021; Flores, Hariz/N-8214-2019; Garcia
   Medina, Sandra/KHC-3931-2024; Islas Flores, Hariz/O-1955-2015;
   Lopez-Martinez, Leticia X./O-6395-2017; Dublan-Garcia,
   Octavio/D-3221-2016; Hernandez-Navarro, Maria Dolores/B-5641-2016;
   Gomez-Olivan, Leobardo Manuel/B-1662-2016
OI Islas Flores, Hariz/0000-0002-0614-4860; Garcia Medina,
   Sandra/0000-0002-3097-109X; NOVOA LUNA, KAREN
   ADRIANA/0000-0002-2493-1470; Lopez-Martinez, Leticia
   X./0000-0002-5572-5434; Dublan-Garcia, Octavio/0000-0001-6264-2912;
   Galar-Martinez, Marcela/0000-0003-1027-8017; Hernandez-Navarro, Maria
   Dolores/0000-0002-4302-7815; Gomez-Olivan, Leobardo
   Manuel/0000-0002-7248-3449
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NR 69
TC 11
Z9 12
U1 0
U2 6
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2314-6133
EI 2314-6141
J9 BIOMED RES INT
JI Biomed Res. Int.
PY 2017
VL 2017
AR 2352594
DI 10.1155/2017/2352594
PG 9
WC Biotechnology & Applied Microbiology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Research & Experimental Medicine
GA EX6SJ
UT WOS:000403372100001
PM 28691017
OA hybrid, Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Fried, Y
   Laurence, GA
   Shirom, A
   Melamed, S
   Toker, S
   Berliner, S
   Shapira, I
AF Fried, Yitzhak
   Laurence, Gregory A.
   Shirom, Arie
   Melamed, Samuel
   Toker, Sharon
   Berliner, Shlomo
   Shapira, Itzhak
TI The Relationship Between Job Enrichment and Abdominal Obesity: A
   Longitudinal Field Study of Apparently Healthy Individuals
SO JOURNAL OF OCCUPATIONAL HEALTH PSYCHOLOGY
LA English
DT Article
DE abdominal obesity; job enrichment; job characteristics; job stress
ID BODY-MASS INDEX; STRESS-INDUCED CORTISOL; PITUITARY-ADRENAL AXIS; WAIST
   CIRCUMFERENCE; WORK DESIGN; ACTIVATION THEORY; CHARACTERISTICS MODEL;
   METABOLIC SYNDROME; PHYSICAL-ACTIVITY; HIP RATIO
AB Obesity has become an epidemic in modern society. However, there is a paucity of research about how job context affects obesity. To enhance our knowledge we used a large, heterogeneous sample of apparently healthy employees (n = 1,949) across two time periods with an average of close to 3.5 years between measures. We tested a hypothesized curvilinear effect of job enrichment on changes in two stress related indicators of abdominal obesity over time: waist circumference (WC) and waist-hip ratio (WHR). Job enrichment consisted of the job dimensions of variety, identity, significance, autonomy, and feedback, and in our analysis we controlled for demographics and health related behaviors, including weekly sports activity, number of cigarettes smoked per day, and weekly alcohol consumption. The results supported the hypothesized U-shaped relationship between job enrichment and changes in both indicators of abdominal obesity over time, such that the level of abdominal obesity was reduced when job enrichment was moderate and was increased when job enrichment was either high or low. As expected, no such association was observed for the general obesity measure of body mass index (BMI). We discuss the theoretical and practical implications of these results.
C1 [Fried, Yitzhak] Syracuse Univ, Martin J Whitman Sch Management, Syracuse, NY 13244 USA.
   [Laurence, Gregory A.] Univ Michigan, Sch Management, Flint, MI 48503 USA.
   [Shirom, Arie; Toker, Sharon] Tel Aviv Univ, Fac Management, IL-69978 Tel Aviv, Israel.
   [Melamed, Samuel] Acad Coll Tel Aviv Yaffo, Tel Aviv, Israel.
   [Melamed, Samuel; Berliner, Shlomo; Shapira, Itzhak] Tel Aviv Univ, Sackler Fac Med, IL-69978 Tel Aviv, Israel.
   [Berliner, Shlomo; Shapira, Itzhak] Tel Aviv Sourasky Med Ctr, Tel Aviv, Israel.
C3 Syracuse University; University of Michigan System; University of
   Michigan Flint; University of Michigan; Tel Aviv University; Tel Aviv
   University; Sackler Faculty of Medicine; Tel Aviv University; Sackler
   Faculty of Medicine; Tel Aviv Sourasky Medical Center
RP Fried, Y (corresponding author), Syracuse Univ, Martin J Whitman Sch Management, 721 Univ Ave, Syracuse, NY 13244 USA.
EM yfried@syr.edu
RI Toker, Sharon/P-5428-2015
OI Toker, Sharon/0000-0001-7621-6607
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NR 101
TC 14
Z9 17
U1 3
U2 32
PU EDUCATIONAL PUBLISHING FOUNDATION-AMERICAN PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST, NE, WASHINGTON, DC 20002-4242 USA
SN 1076-8998
EI 1939-1307
J9 J OCCUP HEALTH PSYCH
JI J. Occup. Health Psychol.
PD OCT
PY 2013
VL 18
IS 4
BP 458
EP 468
DI 10.1037/a0033730
PG 11
WC Public, Environmental & Occupational Health; Psychology, Applied
WE Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; Psychology
GA 232HI
UT WOS:000325483100008
PM 24001329
DA 2025-06-11
ER

PT J
AU Reddy, SS
   Ramatholisamma, P
   Karuna, R
   Saralakumari, D
AF Reddy, Singareddy Sreenivasa
   Ramatholisamma, Pasurla
   Karuna, Rasineni
   Saralakumari, Desireddy
TI Preventive effect of Tinospora cordifolia against high-fructose
   diet-induced insulin resistance and oxidative stress in male Wistar rats
SO FOOD AND CHEMICAL TOXICOLOGY
LA English
DT Article
DE Diabetes mellitus; Oral glucose tolerance test; Medicinal plants;
   Antioxidants; Sweetener; Metabolic syndrome
ID POSTTRANSCRIPTIONAL REGULATION; ERYTHROCYTES; SENSITIVITY; NUTRIENTS;
   BEVERAGES; IMPROVES; HORMONES; CELLS
AB High intake of dietary fructose exerts a number of adverse metabolic effects. The aim of the present study was to investigate whether aqueous extract of Tinospora cordifolia stem (TCAE) alleviates high-fructose diet-induced insulin resistance and oxidative stress in rats. High-fructose diet (66% of fructose) and TCAE (400 mg/kg/day) were given simultaneously for a period of 60 days. Fructose fed rats showed hyperglycemia, hyperinsulinemia. hypertriglyceridemia, impaired glucose tolerance and impaired insulin sensitivity (P<0.05). TCAE treatment prevented the rise in glucose levels by 21.3%, insulin by 51.5%, triglycerides by 54.12% and glucose-insulin index by 59.8% of the fructose fed rats. Regarding liver anti-oxidant status, fructose fed rats showed higher values of lipid peroxidation (91.3%), protein carbonyl groups (44%) and lowered GSH levels (42.1%) and, lowered activities of enzymatic antioxidants, while TCAE treatment prevented all these observed abnormalities. In conclusion, our data indicate the preventive role of T. cordifolia against fructose-induced insulin resistance and oxidative stress; hence this plant could be used as an adjuvant therapy for the prevention and/or management of chronic diseases characterized by hyperinsulinemia, hypertriglyceridemia, insulin resistance and aggravated antioxidant status. (C) 2009 Elsevier Ltd. All rights reserved.
C1 [Reddy, Singareddy Sreenivasa; Karuna, Rasineni; Saralakumari, Desireddy] Sri Krishnadevaraya Univ, Dept Biochem, Anantapur 515003, Andhra Pradesh, India.
   [Ramatholisamma, Pasurla] Sri Venkateswara Univ, Dept Biochem, Tirupati 517502, Andhra Pradesh, India.
C3 Sri Krishnadevaraya University; Sri Venkateswara University
RP Saralakumari, D (corresponding author), Sri Krishnadevaraya Univ, Dept Biochem, Anantapur 515003, Andhra Pradesh, India.
EM skumari1@yahoo.co.in
OI Reddy, Sreenivasa/0000-0003-3777-407X; rasineni,
   Karuna/0000-0002-9581-3957
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NR 49
TC 72
Z9 78
U1 0
U2 2
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0278-6915
EI 1873-6351
J9 FOOD CHEM TOXICOL
JI Food Chem. Toxicol.
PD SEP
PY 2009
VL 47
IS 9
BP 2224
EP 2229
DI 10.1016/j.fct.2009.06.008
PG 6
WC Food Science & Technology; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Toxicology
GA 489PF
UT WOS:000269432000010
PM 19520137
DA 2025-06-11
ER

PT J
AU Davis, KE
   Bennett, MM
   Hillard, CJ
   Whittle, J
   Franco, Z
   Bollaert, RE
   Fitzgerald, JM
AF Davis, Kaley E.
   Bennett, Meghan M.
   Hillard, Cecilia J.
   Whittle, Jeffrey
   Franco, Zeno
   Bollaert, Rachel E.
   Fitzgerald, Jacklynn M.
TI Effect of trauma type and trauma burden on self-efficacy for physical
   exercise in military veterans
SO TRAUMA-ENGLAND
LA English
DT Article; Early Access
DE Exercise cognition; self-efficacy; military veterans; post-traumatic
   stress disorder; trauma
ID POSTTRAUMATIC-STRESS-DISORDER; METABOLIC SYNDROME; HEALTH; RESILIENCE;
   EXPOSURE; HEART; RISK
AB Introduction United States (U.S.) military veterans experience significant physical health problems. Lifestyle modifications, such as increasing daily physical activity, are often considered the first course of action in treatment for the general public. However, veterans report low levels of physical activity, often due to perceived barriers to engaging in exercise. Trauma exposure type and cumulative trauma burden may be differentially associated with exercise attitudes and behaviors.Methods We surveyed U.S. military veterans on perceived self-efficacy to overcome barriers to engaging in exercise and physical activity levels. Additionally, we explored the relationship between the type of traumatic event exposure and cumulative trauma on these constructs.Results Veterans exposed to sexually aggressive traumatic events (vs. did not) reported significantly lower physical activity levels; no difference in perceived self-efficacy to overcome barriers to exercise existed between groups. Greater cumulative trauma was associated with lower physical activity and self-efficacy to engage in exercise.Conclusion These novel results indicate that both trauma type and cumulative trauma burden should be considered when designing exercise interventions for military veterans.
C1 [Davis, Kaley E.; Bennett, Meghan M.; Fitzgerald, Jacklynn M.] Marquette Univ, Dept Psychol, Cramer Hall,604 N 16th St, Milwaukee, WI 53233 USA.
   [Hillard, Cecilia J.] Med Coll Wisconsin, Dept Pharmacol & Toxicol, Milwaukee, WI USA.
   [Whittle, Jeffrey] Zablocki Vet Affairs Med Ctr, Div Med, Milwaukee, WI USA.
   [Franco, Zeno] Med Coll Wisconsin, Dept Family & Community Med, Milwaukee, WI USA.
   [Bollaert, Rachel E.] Marquette Univ, Dept Phys Therapy, Program Exercise Sci, Milwaukee, WI 53233 USA.
C3 Marquette University; Medical College of Wisconsin; Medical College of
   Wisconsin; Marquette University
RP Davis, KE (corresponding author), Marquette Univ, Dept Psychol, Cramer Hall,604 N 16th St, Milwaukee, WI 53233 USA.
EM kaley.davis@marquette.edu
RI Fitzgerald, Jacklynn/Q-3958-2019
OI Davis, Kaley/0000-0003-4826-2934
FU National Center for Advancing Translational Sciences, National
   Institutes of Health [UL1TR001436]
FX The authors disclosed receipt of the following financial support for the
   research, authorship, and/or publication of this article: This research
   was supported by the National Center for Advancing Translational
   Sciences, National Institutes of Health, Award Number UL1TR001436 (PIs:
   Fitzgerald, Bollaert, Hillard).
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NR 45
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PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1460-4086
EI 1477-0350
J9 TRAUMA
JI Trauma
PD 2024 FEB 21
PY 2024
DI 10.1177/14604086241231373
EA FEB 2024
PG 13
WC Emergency Medicine
WE Emerging Sources Citation Index (ESCI)
SC Emergency Medicine
GA IU6S3
UT WOS:001168895700001
DA 2025-06-11
ER

PT J
AU Wong, SK
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   Masbah, N
   Fahami, NAM
   Mohamed, IN
   Shuid, AN
   Saad, QM
   Abdullah, A
   Mohamad, NV
   Ibrahim, NI
   Pang, KL
   Chow, YY
   Thong, BKS
   Subramaniam, S
   Chan, CY
   Ima-Nirwana, S
   Chin, KY
AF Wong, Sok Kuan
   Kamisah, Yusof
   Mohamed, Norazlina
   Muhammad, Norliza
   Masbah, Norliana
   Fahami, Nur Azlina Mohd
   Mohamed, Isa Naina
   Shuid, Ahmad Nazun
   Saad, Qodriyah Mohd
   Abdullah, Azman
   Mohamad, Nur-Vaizura
   Ibrahim, Nurul' Izzah
   Pang, Kok-Lun
   Chow, Yoke Yue
   Thong, Benjamin Ka Seng
   Subramaniam, Shaanthana
   Chan, Chin Yi
   Ima-Nirwana, Soelaiman
   Chin, Kok-Yong
TI Potential Role of Tocotrienols on Non-Communicable Diseases: A Review of
   Current Evidence
SO NUTRIENTS
LA English
DT Review
DE cancer; musculoskeletal disease; metabolic syndrome; osteoporosis;
   peptic ulcer; vitamin E
ID PALM-VITAMIN-E; INDUCED GASTRIC-LESIONS; RICE BRAN OIL; BREAST-CANCER
   CELLS; HELICOBACTER-PYLORI INFECTION; ENDOPLASMIC-RETICULUM STRESS;
   ANTIOXIDANT ENZYMES ACTIVITY; ACTIVATED RECEPTOR-GAMMA; DIETARY
   ALPHA-TOCOPHEROL; BONE-MINERAL DENSITY
AB Tocotrienol (T3) is a subfamily of vitamin E known for its wide array of medicinal properties. This review aimed to summarize the health benefits of T3, particularly in prevention or treatment of non-communicable diseases (NCDs), including cardiovascular, musculoskeletal, metabolic, gastric, and skin disorders, as well as cancers. Studies showed that T3 could prevent various NCDs, by suppressing 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) in the mevalonate pathway, inflammatory response, oxidative stress, and alternating hormones. The efficacy of T3 in preventing/treating these NCDs is similar or greater compared to tocopherol (TF). TF may lower the efficacy of T3 because the efficacy of the combination of TF and T3 was lower than T3 alone in some studies. Data investigating the effects of T3 on osteoporosis, arthritis, and peptic ulcers in human are limited. The positive outcomes of T3 treatment obtained from the preclinical studies warrant further validation from clinical trials.
C1 [Wong, Sok Kuan; Kamisah, Yusof; Mohamed, Norazlina; Muhammad, Norliza; Masbah, Norliana; Fahami, Nur Azlina Mohd; Mohamed, Isa Naina; Shuid, Ahmad Nazun; Saad, Qodriyah Mohd; Abdullah, Azman; Mohamad, Nur-Vaizura; Ibrahim, Nurul' Izzah; Pang, Kok-Lun; Chow, Yoke Yue; Thong, Benjamin Ka Seng; Subramaniam, Shaanthana; Chan, Chin Yi; Ima-Nirwana, Soelaiman; Chin, Kok-Yong] Univ Kebangsaan Malaysia, Fac Med, Dept Pharmacol, Jalan Yaacob Latif, Kuala Lumpur 56000, Malaysia.
C3 Universiti Kebangsaan Malaysia
RP Chin, KY (corresponding author), Univ Kebangsaan Malaysia, Fac Med, Dept Pharmacol, Jalan Yaacob Latif, Kuala Lumpur 56000, Malaysia.
EM jocylnwsk@gmail.com; kamisah_y@ppukm.ukm.edu.my;
   azlina@ppukm.ukm.edu.my; norliza_ssp@ppukm.ukm.edu.my;
   norliana.masbah@ppukm.ukm.edu.my; nurazlinamf@ukm.edu.my;
   isanaina@ppukm.ukm.edu.my; anazrun@ukm.edu.my; qodryrz@ppukm.ukm.edu.my;
   azman.abdullah@ppukm.ukm.edu.my; vaizuramohd@gmail.com;
   nurulizzah88@gmail.com; pangkoklun@gmail.com; yokeyue95@gmail.com;
   benjamin6126@live.com.my; shaanthana_bks@hotmail.com;
   chanchinyi94@gmail.com; imasoel@ppukm.ukm.edu.my;
   chinkokyong@ppukm.ukm.edu.my
RI Mohamed, Norazlina/M-7306-2017; Mohamad, Nur-Vaizura/ABA-2933-2021;
   SHUID, AHMAD/AAS-7556-2020; Ibrahim, Nurul/X-7167-2019; Abdullah,
   Azman/HOF-6275-2023; CHAN, CHIN/G-9055-2018; Soelaiman, Ima/C-4289-2017;
   Pang, Kok/W-2157-2019; Wong, Sok Kuan/I-1243-2016; Kamisah,
   Yusof/D-8054-2012; Thong, Benjamin Ka Seng/U-3334-2019; Chin,
   Kok-Yong/B-6309-2015
OI shuid, ahmad nazrun/0000-0003-3526-990X; Pang, Kok
   Lun/0000-0003-2219-6297; Wong, Sok Kuan/0000-0003-1184-4551; Kamisah,
   Yusof/0000-0002-9363-8235; Mohamad, Nur-Vaizura/0000-0002-6254-5132; Nur
   Azlina, Mohd Fahami/0000-0002-3458-0440; Thong, Benjamin Ka
   Seng/0000-0003-1096-6936; Chin, Kok-Yong/0000-0001-6628-1552
FU Universiti Kebangsaan Malaysia [FF-2017-052, MI-2019-006]
FX We thank Universiti Kebangsaan Malaysia for supporting this work via
   FF-2017-052 and MI-2019-006 grants.
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NR 421
TC 53
Z9 55
U1 1
U2 12
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JAN
PY 2020
VL 12
IS 1
AR 259
DI 10.3390/nu12010259
PG 84
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nutrition & Dietetics
GA KQ3KN
UT WOS:000516825500259
PM 31963885
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Becker, C
   Kukat, A
   Szczepanowska, K
   Hermans, S
   Senft, K
   Brandscheid, CP
   Maiti, P
   Trifunovic, A
AF Becker, Christina
   Kukat, Alexandra
   Szczepanowska, Karolina
   Hermans, Steffen
   Senft, Katharina
   Brandscheid, Christoph Paul
   Maiti, Priyanka
   Trifunovic, Aleksandra
TI CLPP deficiency protects against metabolic syndrome but hinders adaptive
   thermogenesis
SO EMBO REPORTS
LA English
DT Article
DE CLPP deficiency; fatty acid oxidation; metabolism; thermogenesis; VLCAD
ID FATTY-ACID OXIDATION; INSULIN-RESISTANCE; POLYMERASE-GAMMA;
   SKELETAL-MUSCLE; MICE; OBESITY; MTDNA; DYSFUNCTION; EXPRESSION;
   MUTATIONS
AB Mitochondria are fundamental for cellular metabolism as they are both a source and a target of nutrient intermediates originating from converging metabolic pathways, and their role in the regulation of systemic metabolism is increasingly recognized. Thus, maintenance of mitochondrial homeostasis is indispensable for a functional energy metabolism of the whole organism. Here, we report that loss of the mitochondrial matrix protease CLPP results in a lean phenotype with improved glucose homeostasis. Whole-body CLPP-deficient mice are protected from diet-induced obesity and insulin resistance, which was not present in mouse models with either liver- or muscle-specific depletion of CLPP. However, CLPP ablation also leads to a decline in brown adipocytes function leaving mice unable to cope with a cold-induced stress due to non-functional adaptive thermogenesis. These results demonstrate a critical role for CLPP in different metabolic stress conditions such as high-fat diet feeding and cold exposure providing tools to understand pathologies with deregulated Clpp expression and novel insights into therapeutic approaches against metabolic dysfunctions linked to mitochondrial diseases.
C1 [Becker, Christina; Kukat, Alexandra; Szczepanowska, Karolina; Hermans, Steffen; Senft, Katharina; Brandscheid, Christoph Paul; Maiti, Priyanka; Trifunovic, Aleksandra] Univ Cologne, Med Fac, Cologne Excellence Cluster Cellular Stress Respon, Cologne, Germany.
   [Becker, Christina; Kukat, Alexandra; Szczepanowska, Karolina; Hermans, Steffen; Senft, Katharina; Brandscheid, Christoph Paul; Maiti, Priyanka; Trifunovic, Aleksandra] Univ Cologne, Med Fac, Inst Mitochondrial Dis & Aging, Cologne, Germany.
   [Trifunovic, Aleksandra] Univ Cologne, Ctr Mol Med CMMC, Cologne, Germany.
C3 University of Cologne; University of Cologne; University of Cologne
RP Trifunovic, A (corresponding author), Univ Cologne, Med Fac, Cologne Excellence Cluster Cellular Stress Respon, Cologne, Germany.; Trifunovic, A (corresponding author), Univ Cologne, Med Fac, Inst Mitochondrial Dis & Aging, Cologne, Germany.; Trifunovic, A (corresponding author), Univ Cologne, Ctr Mol Med CMMC, Cologne, Germany.
EM aleksandra.trifunovic@uk-koeln.de
RI Szczepanowska, Karolina/ABC-1404-2020; Trifunovic,
   Aleksandra/HHZ-1296-2022; Maiti, Priyanka/AAA-6903-2020
OI Szczepanowska, Karolina/0000-0003-4689-2350; Maiti,
   Priyanka/0000-0003-4207-0341; Dr. Kukat, Alexandra/0000-0002-8610-0189;
   Brandscheid, Christoph Paul/0000-0001-9739-6643; Trifunovic,
   Aleksandra/0000-0002-5472-3517
FU European Research Council [ERC-StG-2012-310700]; German Research Council
   (Deutsche Forschungsgemeinschaft-DFG) [TR 1018/2-1]; CECAD graduate
   school
FX The work was supported by grants of the European Research Council
   (ERC-StG-2012-310700) and German Research Council (Deutsche
   Forschungsgemeinschaft-DFG-TR 1018/2-1) to A.Trifunovic. C.Becker and
   P.Maiti received scholarships from CECAD graduate school.
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NR 49
TC 43
Z9 44
U1 0
U2 15
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1469-221X
EI 1469-3178
J9 EMBO REP
JI EMBO Rep.
PD MAY
PY 2018
VL 19
IS 5
AR e45126
DI 10.15252/embr.201745126
PG 15
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA GF0PS
UT WOS:000431633800007
PM 29588285
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Song, LX
   Li, Y
   Xu, MH
AF Song, Lixia
   Li, Yong
   Xu, Meihong
TI Exogenous Nucleotides Ameliorate Insulin Resistance Induced by Palmitic
   Acid in HepG2 Cells through the IRS-1/AKT/FOXO1 Pathways
SO NUTRIENTS
LA English
DT Article
DE exogenous nucleotides; HepG2 cell; insulin resistance
ID DIETARY NUCLEOTIDES; OXIDATIVE STRESS; METABOLIC SYNDROME;
   SUPPLEMENTATION; IMPROVES; GLUCOSE; AMPK; SYNTHASE; EXTRACT; MARKERS
AB Nucleotides (NTs) act as pivotal regulatory factors in numerous biological processes, playing indispensable roles in growth, development, and metabolism across organisms. This study delves into the effects of exogenous NTs on hepatic insulin resistance using palmitic-acid-induced HepG2 cells, administering interventions at three distinct dosage levels of exogenous NTs. The findings underscore that exogenous NT intervention augments glucose consumption in HepG2 cells, modulates the expression of glycogen-synthesis-related enzymes (glycogen synthase kinase 3 beta and glycogen synthase), and influences glycogen content. Additionally, it governs the expression levels of hepatic enzymes (hexokinase, phosphoenolpyruvate carboxykinase, and glucose-6-phosphatase). Moreover, exogenous NT intervention orchestrates insulin signaling pathway (insulin receptor substrate-1, protein kinase B, and forkhead box protein O1) and AMP-activated protein kinase (AMPK) activity in HepG2 cells. Furthermore, exogenous NT intervention fine-tunes the expression levels of oxidative stress-related markers (malondialdehyde, glutathione peroxidase, and NADPH oxidase 4) and the expression of inflammation-related nuclear transcription factor (NF-kappa B). Lastly, exogenous NT intervention regulates the expression levels of glucose transporter proteins (GLUTs). Consequently, exogenous NTs ameliorate insulin resistance in HepG2 cells by modulating the IRS-1/AKT/FOXO1 pathways and regulate glucose consumption, glycogen content, insulin signaling pathways, AMPK activity, oxidative stress, and inflammatory status.
C1 [Song, Lixia; Li, Yong; Xu, Meihong] Peking Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Beijing 100191, Peoples R China.
   [Song, Lixia; Li, Yong; Xu, Meihong] Peking Univ, Beijing Key Lab Toxicol Res & Risk Assessment Food, Beijing 100191, Peoples R China.
   [Xu, Meihong] Peking Univ, Inst Med Technol, Hlth Sci Ctr, Beijing 100019, Peoples R China.
C3 Peking University; Peking University; Peking University
RP Xu, MH (corresponding author), Peking Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Beijing 100191, Peoples R China.; Xu, MH (corresponding author), Peking Univ, Beijing Key Lab Toxicol Res & Risk Assessment Food, Beijing 100191, Peoples R China.; Xu, MH (corresponding author), Peking Univ, Inst Med Technol, Hlth Sci Ctr, Beijing 100019, Peoples R China.
EM slx18219898353@163.com; liyong@bjmu.edu.cn; xumeihong@bjmu.edu.cn
RI Song, Lixia/B-1390-2013
OI Xu, Meihong/0000-0001-7201-6982; Li, Yong/0000-0003-3914-5840
FU Beijing Natural Science Foundation [7242186]
FX This research received support from the "Beijing Natural Science
   Foundation" (Project Number: 7242186).
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NR 44
TC 3
Z9 3
U1 8
U2 20
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JUN
PY 2024
VL 16
IS 12
AR 1801
DI 10.3390/nu16121801
PG 17
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA WR9G5
UT WOS:001256712600001
PM 38931156
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Inestrosa, NC
   Ríos, JA
   Cisternas, P
   Tapia-Rojas, C
   Rivera, DS
   Braidy, N
   Zolezzi, JM
   Godoy, JA
   Carvajal, FJ
   Ardiles, AO
   Bozinovic, F
   Palacios, AG
   Sachdev, PS
AF Inestrosa, Nibaldo C.
   Rios, Juvenal A.
   Cisternas, Pedro
   Tapia-Rojas, Cheril
   Rivera, Daniela S.
   Braidy, Nady
   Zolezzi, Juan M.
   Godoy, Juan A.
   Carvajal, Francisco J.
   Ardiles, Alvaro O.
   Bozinovic, Francisco
   Palacios, Adrian G.
   Sachdev, Perminder S.
TI Age Progression of Neuropathological Markers in the Brain of the Chilean
   Rodent Octodon degus, a Natural Model of Alzheimer's Disease
SO BRAIN PATHOLOGY
LA English
DT Article
DE Alzheimer' disease; glial activation; oxidative stress; metabolic
   sensors; neuronal apoptosis and natural model
ID AMYLOID-BETA-PEPTIDE; OXIDATIVE STRESS HYPOTHESIS; MILD COGNITIVE
   IMPAIRMENT; NEURODEGENERATIVE DISEASES; SERUM INTERLEUKIN-6;
   LIPID-PEROXIDATION; METABOLIC SYNDROME; ENERGY-METABOLISM; TRANSGENIC
   MICE; MOUSE MODEL
AB Alzheimer's disease (AD) is the most common neurodegenerative disorder and the leading cause of age-related dementia worldwide. Several models for AD have been developed to provide information regarding the initial changes that lead to degeneration. Transgenic mouse models recapitulate many, but not all, of the features of AD, most likely because of the high complexity of the pathology. In this context, the validation of a wild-type animal model of AD that mimics the neuropathological and behavioral abnormalities is necessary. In previous studies, we have reported that the Chilean rodent Octodon degus could represent a natural model for AD. In the present work, we further describe the age-related neurodegeneration observed in the O.degus brain. We report some histopathological markers associated with the onset progression of AD, such as glial activation, increase in oxidative stress markers, neuronal apoptosis and the expression of the peroxisome proliferative-activated receptor gamma coactivator-1 alpha (PGC-1 alpha). With these results, we suggest that the O.degus could represent a new model for AD research and a powerful tool in the search for therapeutic strategies against AD.
C1 [Inestrosa, Nibaldo C.; Rios, Juvenal A.; Cisternas, Pedro; Tapia-Rojas, Cheril; Godoy, Juan A.; Carvajal, Francisco J.] Pontificia Univ Catolica Chile, Fac Ciencias Biol, Ctr Envejecimiento & Regenerac CARE, Dept Biol Celular & Mol, Santiago, Chile.
   [Inestrosa, Nibaldo C.; Bozinovic, Francisco] Pontificia Univ Catolica Chile, Fac Ciencias Biol, Ctr UC Sindrome Down, Santiago, Chile.
   [Rivera, Daniela S.; Bozinovic, Francisco] Pontificia Univ Catolica Chile, Fac Ciencias Biol, Dept Ecol, Santiago, Chile.
   [Inestrosa, Nibaldo C.; Rivera, Daniela S.; Bozinovic, Francisco] Pontificia Univ Catolica Chile, Fac Ciencias Biol, Ctr Appl Ecol & Sustainabil CAPES, Santiago, Chile.
   [Inestrosa, Nibaldo C.] Univ Magallanes, Ctr Excelencia Biomed Magallanes CEBIMA, Punta Arenas, Chile.
   [Zolezzi, Juan M.] Univ Tarapaca, Fac Ciencias, Dept Biol, Arica, Chile.
   [Ardiles, Alvaro O.; Palacios, Adrian G.] Univ Valparaiso, Fac Ciencias, Ctr Interdisciplinario Neurociencia Valparaiso, Valparaiso, Chile.
   [Inestrosa, Nibaldo C.; Braidy, Nady; Sachdev, Perminder S.] Univ New S Wales, Fac Med, Sch Psychiat, Ctr Hlth Brain Ageing, Sydney, NSW, Australia.
   [Sachdev, Perminder S.] Prince Wales Hosp, Neurosychiatr Inst, Randwick, NSW 2031, Australia.
C3 Pontificia Universidad Catolica de Chile; Pontificia Universidad
   Catolica de Chile; Pontificia Universidad Catolica de Chile; Pontificia
   Universidad Catolica de Chile; Universidad de Magallanes; Universidad de
   Tarapaca; Universidad de Valparaiso; University of New South Wales
   Sydney; University of New South Wales Sydney; Prince of Wales Hospital
   (POWH)
RP Inestrosa, NC (corresponding author), Pontificia Univ Catolica Chile, Fac Biol Sci, CARE Biomed Ctr, Alameda 340,POB 114-D, Santiago 8320000, Chile.
EM ninestrosa@bio.puc.cl
RI Sachdev, Perminder/ABC-1137-2020; Braidy, Nady/G-4928-2012; Rios,
   Juvenal/KII-7543-2024; Ardiles, Alvaro/ABB-1565-2020; Rivera,
   DanielaS/MTF-5052-2025; Godoy Zeballos, Juan A/F-5398-2018; Palacios,
   Adrian/E-9846-2015; Sachdev, Perminder/H-3968-2015
OI Braidy, Nady/0000-0002-0497-5572; Ardiles, Alvaro/0000-0001-8295-2133;
   Rivera, Daniela S./0000-0002-1725-423X; Godoy Zeballos, Juan
   A/0000-0001-9920-6698; Palacios, Adrian/0000-0003-1532-7527; Sachdev,
   Perminder/0000-0002-9595-3220; CISTERNAS, PEDRO/0000-0001-7796-8982;
   Tapia Rojas, Cheril/0000-0002-7084-0318
FU Basal Centre for Excellence in Science and Technology [PFB 12/2007];
   Fondecyt [1120156]; CONICYT; CARE; Alzheimer's Australia; NHMRC Early
   Career Postdoctoral Research Fellowship at University of New South
   Wales, Sydney, Australia; Sociedad Quimica y Minera de Chile (SQM)
FX This work was supported by grants PFB 12/2007 from the Basal Centre for
   Excellence in Science and Technology, Fondecyt 1120156 to NCI,
   predoctoral fellowships to JAR and CT-R from CONICYT and postdoctoral
   fellowships to DSR and AOA from Fondecyt and to PC from CARE. FJC was a
   pre-doctoral fellow from the VRI, Catholic University of Chile. NB is a
   recipient of the Alzheimer's Australia and NHMRC Early Career
   Postdoctoral Research Fellowship at the University of New South Wales,
   Sydney, Australia. We also thank the Sociedad Quimica y Minera de Chile
   (SQM) for a special grant to study "The role of potassium in
   hypertension and cognition." Graphic work was performed with
   Graphique-Science (http://www.illustrative-science.com/).
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NR 91
TC 34
Z9 34
U1 1
U2 20
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1015-6305
EI 1750-3639
J9 BRAIN PATHOL
JI Brain Pathol.
PD NOV
PY 2015
VL 25
IS 6
BP 679
EP 691
DI 10.1111/bpa.12226
PG 13
WC Clinical Neurology; Neurosciences; Pathology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pathology
GA CV5MB
UT WOS:000364313700002
PM 25351914
OA Green Published
DA 2025-06-11
ER

PT J
AU Oriel, RC
   Wiley, CD
   Dewey, MJ
   Vrana, PB
AF Oriel, Roxanne C.
   Wiley, Christopher D.
   Dewey, Michael J.
   Vrana, Paul B.
TI Adaptive genetic variation, stress and glucose regulation
SO DISEASE MODELS & MECHANISMS
LA English
DT Article
ID VOLES MICROTUS-OCHROGASTER; MICE PEROMYSCUS-POLIONOTUS; MOUSE INBRED
   STRAINS; PRAIRIE VOLES; OLDFIELD MICE; Y-CHROMOSOME; GLUCOCORTICOID
   ACTION; INSULIN SENSITIVITY; CORTISOL-LEVELS; COMMON DISEASE
AB Elevated glucose levels in the presence of insulin are indicative of type 2 diabetes and the more inclusive metabolic syndrome. Alleles conferring susceptibility to these and other common conditions may be adaptations to past environments. It is possible that other mammals exhibiting environmental diversity harbor similar variants; therefore, we assessed glucose regulation in two species of deer mice (Peromyscus),a diverse endemic North American group. The prairie deer mouse, P. maniculatus bairdii (BW), and the Oldfield mouse, P. polionotus subgriseus (PO) differ in sexual dimorphism, behavior and habitat. PO animals exhibit better regulatory ability than BW animals, particularly among males, although both species display equivalent insulin levels/responses and non-fasted glucose levels. Hybrid males exhibit a PO glucose challenge response and subsequent analysis of consomic animals implicates Y chromosome variation as the genetic cause. Two pieces of evidence indicate that the male glucose regulatory differences are mediated by stress response: (1) fasting and handling alone account for most of the variation; (2) an inhibitor of glucocorticoid (GC) stress hormone synthesis eliminates these differences. PO males have GC levels that are twice those of BW males, indicating the presence of alleles that attenuate the GC response. We hypothesize that the interspecific physiological and behavioral differences are interrelated and that similar human variants exist.
C1 [Oriel, Roxanne C.; Wiley, Christopher D.; Vrana, Paul B.] Univ Calif Irvine, Sch Med, Dept Biol Chem, Irvine, CA 92799 USA.
   [Dewey, Michael J.] Univ S Carolina, Dept Biol Sci, Peromyscus Genet Stock Ctr, Columbia, SC 29208 USA.
C3 University of California System; University of California Irvine;
   University of South Carolina System; University of South Carolina
   Columbia
RP Vrana, PB (corresponding author), Univ Calif Irvine, Sch Med, Dept Biol Chem, Irvine, CA 92799 USA.
EM pvrana@uci.edu
RI Wiley, Carolyn/JDD-3366-2023
OI Wiley, Christopher/0000-0002-7699-6866
FU Dept of Biological Chemistry, University of California Irvine; NSF
   [MCB-0517754]
FX We thank Lisa Krugner-Higby, Benno Roozenclaal, Maike Sander, and Ping
   Wang for helpful discussions on experimental design. We thank Phillip
   Seymour and JiaYing Yang for aid in procedures. We thank the Dept of
   Biological Chemistry, University of California Irvine and NSF award
   MCB-0517754 for funding. Deposited in PMC for immediate release.
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NR 57
TC 8
Z9 9
U1 0
U2 7
PU COMPANY BIOLOGISTS LTD
PI CAMBRIDGE
PA BIDDER BUILDING, STATION RD, HISTON, CAMBRIDGE CB24 9LF, ENGLAND
SN 1754-8403
EI 1754-8411
J9 DIS MODEL MECH
JI Dis. Model. Mech.
PD NOV-DEC
PY 2008
VL 1
IS 4-5
BP 255
EP 263
DI 10.1242/dmm.000661
PG 9
WC Cell Biology; Medicine, Research & Experimental; Pathology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Research & Experimental Medicine; Pathology
GA 474AK
UT WOS:000268254400014
PM 19093033
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Singh, D
   Dobrowolny, H
   Kapogiannis, D
   Steiner, J
AF Singh, Deepti
   Dobrowolny, Henrik
   Kapogiannis, Dimitrios
   Steiner, Johann
TI Canonical insulin signaling is not significantly impaired in early
   stages of depression
SO EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
LA English
DT Article
DE Major depression; Psychosis; Molecular biology; Exosomes; Insulin;
   Serine-threonine kinases; AKT; GSK3 beta; mTOR; p70S6K; IRS-1
ID EXTRACELLULAR VESICLES; RECEPTOR SUBSTRATE; ABNORMALITIES
AB Patients with major depression (MD) are at high-risk for insulin resistance (IR), type-2 diabetes, metabolic syndrome, cardiovascular morbidity and mortality. However, our recent study published in this journal [Eur Arch Psychiatry Clin Neurosci. 2019 Jun;269(4):373-377], found no evidence of IR in acutely-ill drug-naive first-episode MD (FEMD) using the homeostatic model assessment of insulin resistance (HOMA-IR). We concluded, that MD may be related to impaired glucose/insulin homeostasis in the long-term but not in early disease stages. Now, we performed a complementary analysis of the canonical insulin signalling pathway containing the set of control and FEMD samples from the study mentioned above. The first node (pS312-IRS-1, pY-IRS-1) and downstream pathway which affects glucose and lipid homeostasis (phosphorylated proteins: pS473-AKT, pS9-GSK3 beta, pS2448-mTOR, pT389-p70S6K; total proteins AKT, GSK3P, mTOR, p70S6K) were analyzed by electrochemiluminescence (ECL) in neuronal extracellular vesicles (nEVs) enriched for L1 neural cell adhesion molecule (L1CAM) expression. No significant diagnosis-related differences were observed for the pS312-IRS-1/pYIRS-1 ratio (P = 0.093), but the mean ratio was reduced by similar to 70 in FEMD versus controls. Moreover, omnibus analysis of downstream phosphorylated / total signaling protein ratios and respective post-hoc analyses revealed no significant changes in FEMD patients versus controls (P = 0.734). HAMD-21 scores were not correlated with pS312-IRS-1/pY-IRS-1 or downstream phosphorylated/total signaling protein ratios. In summary, we did not find evidence for altered neuronal insulin signaling in early disease stages of MD. This is in contrast to schizophrenia, where we and other researchers have seen evidence of IR in first-episode patients.
C1 [Singh, Deepti; Dobrowolny, Henrik; Steiner, Johann] Otto von Guericke Univ, Dept Psychiat & Psychotherapy, Magdeburg, Germany.
   [Singh, Deepti; Dobrowolny, Henrik; Steiner, Johann] Otto von Guericke Univ, Lab Translat Psychiat, Magdeburg, Germany.
   [Kapogiannis, Dimitrios] NIA, Lab Neurosci, Intramural Res Program, NIH, 251 Bayview Blvd,8C228, Baltimore, MD 21224 USA.
   [Steiner, Johann] Ctr Behav Brain Sci CBBS, Magdeburg, Germany.
   [Steiner, Johann] Ctr Hlth & Med Prevent CHaMP, Magdeburg, Germany.
   [Steiner, Johann] German Ctr Mental Hlth DZP, Ctr Intervent & Res Adapt & Maladapt Brain Circui, Jena, Germany.
C3 Otto von Guericke University; Otto von Guericke University; National
   Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA)
RP Steiner, J (corresponding author), Otto von Guericke Univ, Dept Psychiat & Psychotherapy, Magdeburg, Germany.; Steiner, J (corresponding author), Otto von Guericke Univ, Lab Translat Psychiat, Magdeburg, Germany.; Kapogiannis, D (corresponding author), NIA, Lab Neurosci, Intramural Res Program, NIH, 251 Bayview Blvd,8C228, Baltimore, MD 21224 USA.; Steiner, J (corresponding author), Ctr Behav Brain Sci CBBS, Magdeburg, Germany.; Steiner, J (corresponding author), Ctr Hlth & Med Prevent CHaMP, Magdeburg, Germany.; Steiner, J (corresponding author), German Ctr Mental Hlth DZP, Ctr Intervent & Res Adapt & Maladapt Brain Circui, Jena, Germany.
EM kapogiannisd@mail.nih.gov; johann.steiner@med.ovgu.de
RI Kapogiannis, Dimitrios/AAW-4934-2020
FU National Institute on Aging, Intramural Research Program
FX This article was funded by National Institute on Aging, Intramural
   Research Program, Dimitrios Kapogiannis.
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NR 10
TC 5
Z9 6
U1 0
U2 2
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0940-1334
EI 1433-8491
J9 EUR ARCH PSY CLIN N
JI Eur. Arch. Psych. Clin. Neurosci.
PD FEB
PY 2023
VL 273
IS 1
BP 283
EP 286
DI 10.1007/s00406-022-01412-w
EA MAY 2022
PG 4
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Psychiatry
GA EW3T1
UT WOS:000791891300001
PM 35524821
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Janssen, I
   Powell, LH
   Matthews, KA
   Cursio, JF
   Hollenberg, SM
   Sutton-Tyrrell, K
   Bromberger, JT
   Everson-Rosee, SA
AF Janssen, Imke
   Powell, Lynda H.
   Matthews, Karen A.
   Cursio, John F.
   Hollenberg, Steven M.
   Sutton-Tyrrell, Kim
   Bromberger, Joyce T.
   Everson-Rosee, Susan A.
TI Depressive symptoms are related to progression of coronary calcium in
   midlife women: The Study of Women's Health Across the Nation (SWAN)
   Heart Study
SO AMERICAN HEART JOURNAL
LA English
DT Article
ID PSYCHOSOCIAL RISK-FACTORS; ELECTRON-BEAM TOMOGRAPHY; ARTERY CALCIUM;
   CARDIOVASCULAR-DISEASE; MENOPAUSAL TRANSITION; METABOLIC SYNDROME;
   SUBCLINICAL ATHEROSCLEROSIS; ASYMPTOMATIC SUBJECTS; AORTIC
   CALCIFICATION; COMPUTED-TOMOGRAPHY
AB Background Major depression and depressive symptoms are associated with cardiovascular disease (CVD), but the impact of depression on early atherogenesis is less well known, particularly in women and minorities. This study examined whether depressive symptoms are associated with progression of coronary artery calcification (CAC) among women at midlife.
   Methods The SWAN is a longitudinal, multisite study assessing health and psychologic factors in midlife women. An ancillary study (SWAN Heart) evaluated subclinical atherosclerosis in women who reported no history of CVD or diabetes. In 346 women, CAC was measured twice by electron beam computed tomography, an average of 2.3 years apart. Progression, defined as an increase by >= 10 Agatston units, was analyzed using relative risk (RR) regression. Depressive symptoms were assessed with the Center for Epidemiologic Studies Depression (CES-D) Scale.
   Results Progression of CAC was observed in 67 women (19.1%). Each 1-SD-higher CES-D score at baseline related to a 25% increased risk of CAC progression (RR 1.25, 95% CI 1.06-1.47, P = .007), adjusting for age, time between scans, ethnicity, education, menopausal status, and known CVD risk factors. This risk was similar to the risk induced by body mass index (RR 1.31, 95% CI 1.11-1.54, P = .001) and systolic blood pressure (RR 1.28, 95% CI 1.06-1.55, P = .01).
   Conclusions Depressive symptoms were independently associated with progression of CAC in this cohort of midlife women. Depressive symptoms may represent a risk factor that is potentially modifiable for early prevention of CVD in women. (Am Heart J 2011;161:1186-1191.e1.)
C1 [Janssen, Imke; Powell, Lynda H.; Cursio, John F.] Rush Univ, Med Ctr, Dept Prevent Med, Chicago, IL 60612 USA.
   [Matthews, Karen A.] Univ Pittsburgh, Sch Med, Dept Psychiat, Pittsburgh, PA USA.
   [Hollenberg, Steven M.] Cooper Univ Hosp, Div Cardiol, Camden, NJ USA.
   [Sutton-Tyrrell, Kim; Bromberger, Joyce T.] Univ Pittsburgh, Grad Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA USA.
   [Everson-Rosee, Susan A.] Univ Minnesota, Dept Med, Minneapolis, MN 55455 USA.
C3 Rush University; Pennsylvania Commonwealth System of Higher Education
   (PCSHE); University of Pittsburgh; Cooper University Hospital;
   Pennsylvania Commonwealth System of Higher Education (PCSHE); University
   of Pittsburgh; University of Minnesota System; University of Minnesota
   Twin Cities
RP Janssen, I (corresponding author), Rush Univ, Med Ctr, Dept Prevent Med, 1700 W van Buren,Suite 470, Chicago, IL 60612 USA.
EM Imke_Janssen@rush.edu
RI Cursio, John/AFP-2825-2022; Everson-Rose, Susan/L-7582-2017; Hollenberg,
   Steven/AAR-4522-2020
OI Everson-Rose, Susan/0000-0002-9839-2537; Cursio,
   John/0000-0003-2131-1767; Janssen, Imke/0000-0003-1184-2812; bromberger,
   joyce/0000-0001-7101-3800
FU National Institutes of Health through the National Institute of Aging;
   National Institute of Nursing Research; National Institutes of Health
   Office of Research on Women's Health [NR004061, AG012505, AG012535,
   AG012531, AG012539, AG012546, AG012553, AG012554, AG012495]; National
   Heart, Lung, and Blood Institute [HL065581, HL065591, HL089862]; Charles
   J. and Margaret Roberts Trust
FX The SWAN study has grant support from the National Institutes of Health
   through the National Institute of Aging, the National Institute of
   Nursing Research, and the National Institutes of Health Office of
   Research on Women's Health (grants NR004061, AG012505, AG012535,
   AG012531, AG012539, AG012546, AG012553, AG012554, and AG012495).SWAN
   Heart was supported by grants from the National Heart, Lung, and Blood
   Institute (HL065581, HL065591, HL089862).The Chicago site of the SWAN
   Heart study was also supported by the Charles J. and Margaret Roberts
   Trust.
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NR 41
TC 49
Z9 53
U1 0
U2 15
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0002-8703
EI 1097-5330
J9 AM HEART J
JI Am. Heart J.
PD JUN
PY 2011
VL 161
IS 6
BP 1186
EP U1600
DI 10.1016/j.ahj.2011.03.017
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Cardiovascular System & Cardiology
GA 773WU
UT WOS:000291343000024
PM 21641367
OA Green Accepted
DA 2025-06-11
ER

PT J
AU De Long, NE
   Barry, EJ
   Pinelli, C
   Wood, GA
   Hardy, DB
   Morrison, KM
   Taylor, VH
   Gerstein, HC
   Holloway, AC
AF De Long, Nicole E.
   Barry, Eric J.
   Pinelli, Christopher
   Wood, Geoffrey A.
   Hardy, Daniel B.
   Morrison, Katherine M.
   Taylor, Valerie H.
   Gerstein, Hertzel C.
   Holloway, Alison C.
TI Antenatal exposure to the selective serotonin reuptake inhibitor
   fluoxetine leads to postnatal metabolic and endocrine changes associated
   with type 2 diabetes in Wistar rats
SO TOXICOLOGY AND APPLIED PHARMACOLOGY
LA English
DT Article
DE Beta cell; Inflammation; Depression; Adiposity; Nonalcoholic
   steatohepatitis; Dyslipidernia
ID FATTY LIVER-DISEASE; PRENATAL EXPOSURE; ANTIDEPRESSANT CONCENTRATIONS;
   DEPRESSION PREVALENCE; PERINATAL DEPRESSION; RAPHE NUCLEI; IN-UTERO;
   PREGNANCY; SSRIS; FETAL
AB Hypothesis: 10-15% of women take antidepressant medications during pregnancy. A recent clinical study reported that the use of selective serotonin reuptake inhibitor antidepressants during pregnancy is linked with an increased risk of postnatal obesity. While obesity is often associated with fatty liver, dyslipidemia and inflammation, to date, the effects of perinatal exposure to SSRIs on these outcomes are unknown.
   Methods: Female nulliparous Wistar rats were given vehicle (N = 15) or fluoxetine hydrochloride (FLX 10 mg/kg/d; N = 15) orally for 2 weeks prior to mating until weaning. We assessed glucometabolic changes and hepatic pathophysiology in the offspring.
   Results: Fluoxetine exposed offspring demonstrated altered glucose homeostasis without any alterations to beta cell mass. FLX-exposed offspring had a significant increase in the number of offspring with mild to moderate NASH and dyslipidemia. There was also increased inflammation of the liver in FIX-exposed offspring; males had significant elevations in TNF alpha, IL6 and monocyte chemoattractant protein 1 (MCP1), while female offspring had higher expression of TNF alpha, and increased macrophage infiltration (MCP1).
   Limitations: This is an animal study. Further research examining the metabolic outcomes of children exposed to antidepressants in utero are required, given the increase in childhood obesity and psychiatric medication use during pregnancy.
   Conclusion: These data demonstrate that fetal and neonatal exposure to FIX results in evidence of increased adiposity, fatty liver and abnormal glycemic control. Since these are all hallmarks of the metabolic syndrome, this raises concerns regarding the long term metabolic sequelae of fetal exposure to SSRIs in human populations. (C) 2015 Elsevier Inc. All rights reserved.
C1 [De Long, Nicole E.; Barry, Eric J.; Holloway, Alison C.] McMaster Univ, Dept Obstet & Gynecol, Hamilton, ON L8S 4K1, Canada.
   [Pinelli, Christopher; Wood, Geoffrey A.] Univ Guelph, Dept Pathobiol, Guelph, ON N1G 2W1, Canada.
   [Hardy, Daniel B.] Univ Western, Dept Obstet & Gynecol, Physiol & Pharmacol, London, ON N6A 3K6, Canada.
   [Morrison, Katherine M.] McMaster Univ, Dept Pediat, Hamilton, ON L8S 4K1, Canada.
   [Taylor, Valerie H.] Univ Toronto, Dept Psychiat, Toronto, ON M5S 1A1, Canada.
   [Gerstein, Hertzel C.] McMaster Univ, Dept Med, Hamilton, ON L8S 4K1, Canada.
C3 McMaster University; University of Guelph; McMaster University;
   University of Toronto; McMaster University
RP Holloway, AC (corresponding author), McMaster Univ, Dept Obstet & Gynecol, RM HSC-3N52,1280 Main St West, Hamilton, ON L8S 4K1, Canada.
EM hollow@mcmaster.ca
RI Morrison, Katherine/AAO-8046-2021; Gerstein, Hertzel/B-1235-2013; Wood,
   Geoffrey/ABB-2052-2021; Hardy, Daniel/GYU-8976-2022; Taylor,
   Valerie/H-6242-2015
OI Taylor, Valerie/0000-0002-8948-638X; Hardy, Daniel/0000-0001-5445-273X;
   Wood, Geoffrey/0000-0003-1756-8607; Gerstein,
   Hertzel/0000-0001-8072-2836; Morrison, Katherine/0000-0002-1737-256X
FU Canadian Institutes of Health Research [MOP 119323, MOP 111001]; CIHR;
   Early Development; Impact on Health (REDIH)
FX Funding for this study was provided by the Canadian Institutes of Health
   Research (MOP 119323 and MOP 111001). Salary support for NED was
   provided by the CIHR Training Program in Reproduction, Early Development
   and the Impact on Health (REDIH).
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NR 67
TC 19
Z9 20
U1 0
U2 16
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0041-008X
EI 1096-0333
J9 TOXICOL APPL PHARM
JI Toxicol. Appl. Pharmacol.
PD MAY 15
PY 2015
VL 285
IS 1
BP 32
EP 40
DI 10.1016/j.taap.2015.03.006
PG 9
WC Pharmacology & Pharmacy; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Toxicology
GA CH1AG
UT WOS:000353752900004
PM 25771129
DA 2025-06-11
ER

PT J
AU Simeonova, R
   Gevrenova, R
   Marinov, L
   Savov, Y
   Zheleva-Dimitrova, D
AF Simeonova, Rumyana
   Gevrenova, Reneta
   Marinov, Lyubomir
   Savov, Yonko
   Zheleva-Dimitrova, Dimitrina
TI Nephroprotective Effects of Tanacetum balsamita Extract on
   Metabolic-Induced Renal Injury (MIRI) in Rats
SO CURRENT ISSUES IN MOLECULAR BIOLOGY
LA English
DT Article
DE Tanacetum balsamita; diabetes type 2; metabolic
   syndrome; diabetic nephropathies; oxidative stress
ID OXIDATIVE STRESS; GROWTH-FACTOR; GLUTATHIONE; INFLAMMATION
AB The progression of type 2 diabetes is associated with multiple complications, one of which is diabetic nephropathy (DN). This study aimed at investigating the nephroprotective potential of two doses 150 mg/kg and 300 mg/kg of Tanacetum balsamita leaf extract (ETB) on metabolic-induced renal injury (MIRI) in rats. Markers of renal oxidative stress and antioxidant defense, histopathology, serum biochemistry, and urinalysis were measured. Blood glucose level and arterial blood pressure were assessed weekly for the experimental period of eight weeks. ETB at a high dose significantly decreased the blood glucose levels and mildly lowered systolic pressure in diabetic rats. In the kidney, ETB restored the antioxidant marker malondialdehyde, reduced glutathione, and markedly increased enzymatic activity related to GSH turnover by 46% (GPx), 22% (GR), 32% (GST), and 96% (SOD). ETB reduced elevated urea and creatinine levels and alleviated the proteinuria along with other urinalysis parameters. Histopathological examination of the kidney supported the observed protective effects. Both doses of the ETB ameliorated most of the investigated parameters similarly to positive controls enalapril and acarbose. ETB benefits on MIRI-induced damages could be associated with high levels of mono- and dicaffeoylquinic acids together with a series of methoxylated flavones and flavonols, which may hold significance for its antidiabetic and nephroprotective activity.
C1 [Simeonova, Rumyana; Marinov, Lyubomir] Med Univ Sofia, Fac Pharm, Dept Pharmacol Pharmacotherapy & Toxicol, Sofia 1000, Bulgaria.
   [Gevrenova, Reneta; Zheleva-Dimitrova, Dimitrina] Med Univ Sofia, Fac Pharm, Dept Pharmacognosy, Sofia 1000, Bulgaria.
   [Savov, Yonko] Inst Emergency Med N I Pirogov, Bul Totleben 21, Sofia 1000, Bulgaria.
C3 Medical University Sofia; Medical University Sofia
RP Simeonova, R (corresponding author), Med Univ Sofia, Fac Pharm, Dept Pharmacol Pharmacotherapy & Toxicol, Sofia 1000, Bulgaria.; Zheleva-Dimitrova, D (corresponding author), Med Univ Sofia, Fac Pharm, Dept Pharmacognosy, Sofia 1000, Bulgaria.
EM rsimeonova@pharmfac.mu-sofia.bg; rgevrenova@pharmfac.mu-sofia.bg;
   lmarinov@pharmfac.mu-sofia.bg; yonko_savov@hotmail.com;
   dzheleva@pharmfac.mu-sofia.bg
RI Simeonova, Vitanska, Rumyana/G-8002-2019; Gevrenova,
   Reneta/AEA-8791-2022; Marinov, Lyubomir/AAW-2055-2021;
   Zheleva-Dimitrova, Dimitrina/GQI-1010-2022
FU European Union-NextGenerationEU [BG-RRP-2.004-0004-C01]; European
   Union-NextGenerationEU, through the National Recovery and Resilience
   Plan of the Republic of Bulgaria
FX This study was financed by the European Union-NextGenerationEU, through
   the National Recovery and Resilience Plan of the Republic of Bulgaria,
   project BG-RRP-2.004-0004-C01 "Strategic research and innovation program
   for development of Medical University-Sofia".
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NR 54
TC 0
Z9 0
U1 0
U2 0
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
SN 1467-3037
EI 1467-3045
J9 CURR ISSUES MOL BIOL
JI Curr. Issues Mol. Biol.
PD APR 21
PY 2025
VL 47
IS 4
AR 293
DI 10.3390/cimb47040293
PG 17
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 1VC7P
UT WOS:001474379100001
DA 2025-06-11
ER

PT J
AU Nakandakare-Maia, ET
   Siqueira, JS
   Ferron, AJT
   Vieira, TA
   Palacio, TLN
   Grandini, NA
   Garcia, JL
   Belin, MA
   Altomare, A
   Baron, G
   Aldini, G
   Francisqueti-Ferron, FV
   Corre, CR
AF Nakandakare-Maia, Erika Tiemi
   Siqueira, Juliana Silva
   Ferron, Artur Junio Togneri
   Vieira, Taynara Aparecida
   Palacio, Thiago Luiz Novaga
   Grandini, Nubia Alves
   Garcia, Jessica Leite
   Belin, Matheus Antonio
   Altomare, Alessandra
   Baron, Giovanna
   Aldini, Giancarlo
   Francisqueti-Ferron, Fabiane Valentini
   Corre, Camila Renata
TI Treatment with bergamot (Citrus bergamia) leaves extract
   attenuates leptin resistance in obese rats
SO MOLECULAR AND CELLULAR ENDOCRINOLOGY
LA English
DT Article
DE Bergamot; Bioactive compounds; Polyphenols; Leptin resistance; Obesity
ID OXIDATIVE STRESS
AB Low-grade chronic inflammation in obesity is associated with leptin resistance. In order to alleviate this path- ological condition, bioactive compounds capable of attenuating oxidative stress and inflammation have been researched, and bergamot (Citrus bergamia) presents these properties. The aim was to evaluate the effect of bergamot leaves extract on leptin resistance in obese rats. Animals were divided into 2 groups: control diet (C, n=10) and high sugar-fat diet (HSF, n=20) for 20 weeks. After detecting hyperleptinemia, animals were divided to begin the treatment with bergamot leaves extract (BLE) for 10 weeks: C + placebo (n=7), HSF + placebo (n=7), and HSF + BLE (n=7) by gavage (50 mg/kg). Evaluations included nutritional, hormonal and metabolic parameters; adipose tissue dysfunction; inflammatory, oxidative markers and hypothalamic leptin pathway. HSF group presented obesity, metabolic syndrome, adipose tissue dysfunction, hyperleptinemia and leptin resistance compared to control group. However, the treated group showed a decrease in caloric consumption and atten- uation of insulin resistance. Moreover, dyslipidemia, adipose tissue function, and leptin levels showed an improvement. At the level of the hypothalamus, the treated group showed a reduction of oxidative stress, inflammation and modulation of leptin signaling. In conclusion, BLE properties were able to improve leptin resistance through recovery of the hypothalamic pathway.
C1 [Nakandakare-Maia, Erika Tiemi; Siqueira, Juliana Silva; Ferron, Artur Junio Togneri; Vieira, Taynara Aparecida; Palacio, Thiago Luiz Novaga; Grandini, Nubia Alves; Garcia, Jessica Leite; Belin, Matheus Antonio; Francisqueti-Ferron, Fabiane Valentini; Corre, Camila Renata] Sao Paulo State Univ UNESP, Med Sch, BR-18618687 Botucatu, Brazil.
   [Altomare, Alessandra; Baron, Giovanna; Aldini, Giancarlo] Univ Milan, Dept Pharmaceut Sci, I-20133 Milan, Italy.
   [Ferron, Artur Junio Togneri; Francisqueti-Ferron, Fabiane Valentini] Integrated Coll Bauru FIB, BR-17056100 Bauru, Brazil.
   [Nakandakare-Maia, Erika Tiemi] Sao Paulo Univ UNESP, Botucatu Med Sch, Montenegro Ave, BR-18618687 Botucatu, Brazil.
C3 Universidade Estadual Paulista; University of Milan
RP Nakandakare-Maia, ET (corresponding author), Sao Paulo Univ UNESP, Botucatu Med Sch, Montenegro Ave, BR-18618687 Botucatu, Brazil.
EM erika.nakandakare@gmail.com
RI Siqueira, Juliana/AAR-7994-2021; Francisqueti-Ferron,
   Fabiane/M-4919-2017; aldini, giancarlo/C-3533-2013; Belin,
   Matheus/AAG-5163-2019; Ferron, Artur/M-5194-2017; Baron,
   Giovanna/ABE-3121-2020; Correa, Camila/Q-2071-2019; Leite Garcia,
   Jessica/Q-8779-2018; Novaga Palacio, Thiago Luiz/AGP-5802-2022; Alves
   Grandini, Nubia/HHZ-5975-2022; Aparecida Vieira, Taynara/JFK-7958-2023
OI Leite Garcia, Jessica/0000-0002-3670-243X; Filiol Belin, Matheus
   Antonio/0000-0002-1656-405X; Silva Siqueira,
   Juliana/0000-0003-3172-2199; Nakandakare Maia, Erika
   Tiemi/0000-0003-1253-001X; Baron, Giovanna/0000-0002-9335-6318; Novaga
   Palacio, Thiago Luiz/0000-0001-9568-7156; Alves Grandini,
   Nubia/0000-0002-1696-4993; Aparecida Vieira,
   Taynara/0000-0002-5312-0060; Correa, Camila Renata/0000-0001-8493-5329
FU Sao Paulo Research Foundation (FAPESP) [2018/15294-3]
FX Sao Paulo Research Foundation (FAPESP) [Grant number 2018/15294-3] .
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NR 31
TC 7
Z9 8
U1 2
U2 6
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0303-7207
EI 1872-8057
J9 MOL CELL ENDOCRINOL
JI Mol. Cell. Endocrinol.
PD MAY 1
PY 2023
VL 566
AR 111908
DI 10.1016/j.mce.2023.111908
EA MAR 2023
PG 7
WC Cell Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Endocrinology & Metabolism
GA A0HQ7
UT WOS:000952029200001
PM 36868453
DA 2025-06-11
ER

PT J
AU Chen, C
   Kang, MS
   Wang, QW
   Liu, WL
   Yang, MG
   Liang, SX
   Xiang, Q
   Han, X
   Tao, J
AF Chen, Cong
   Kang, Meisong
   Wang, Qiaowen
   Liu, Weilin
   Yang, Minguang
   Liang, Shengxiang
   Xiang, Qing
   Han, Xiao
   Tao, Jing
TI Combination of Anoectochilus roxburghii Polysaccharide and
   Exercise Ameliorates Diet-Induced Metabolic Disorders in Obese Mice
SO FRONTIERS IN NUTRITION
LA English
DT Article
DE Anoectochilus roxburghii polysaccharide; exercise; metabolic disorders;
   type 2 diabetes; oxidative stress
ID OXIDATIVE STRESS; ANTIHYPERGLYCEMIC ACTIVITY; CARBON-TETRACHLORIDE;
   FORMOSANUS; INFLAMMATION; ANTIOXIDANT; DYSFUNCTION; EXTRACT; LEPTIN
AB Metabolic syndrome is a cluster of metabolic disorders that threatens public health. Nevertheless, its exact mechanism and relative intervention remain largely obscure. Accumulating evidence indicate that tither Anoectochilus roxburghii polysaccharide (ARP) or exercise (EX) exhibited the beneficial effects on metabolic health. However, the synergetic beneficial effects of ARP and EX as a combined intervention on obesity-induced metabolic disorders remain largely obscure. Male C57BL/6 mice were fed a high-fat diet (HFD) and intervened with ARP and EX for 12 continuous weeks. The results indicated that the ARP, EX, and ARP combined with EX treatment group regulated lipogenesis by suppressing the fatty acid pathway, dampening the system oxidative stress by stimulating Nrf2-mediated phase II enzyme system, and promoting the mitochondrial function by activating the mitochondrial complexes and PGC-1 alpha in HFD mice. More importantly, the combination of ARP and EX showed an even greater beneficial effects relative to either ARP or EX alone, especially in decreasing reactive oxygen species (ROS) level and increasing adenosine triphosphate (ATP) content. Taken together, these findings further confirmed that ARP and EX could be effective interventions on obesity-induced metabolic abnormalities, and that the combination of ARP and EX exhibited the beneficial synergetic effects.
C1 [Chen, Cong; Liu, Weilin; Yang, Minguang; Liang, Shengxiang; Xiang, Qing; Tao, Jing] Fujian Univ Tradit Chinese Med, Inst Rehabil Ind, Fuzhou, Peoples R China.
   [Kang, Meisong; Wang, Qiaowen; Han, Xiao] Fuzhou Univ, Coll Biol Sci & Engn, Fuzhou, Peoples R China.
C3 Fujian University of Traditional Chinese Medicine; Fuzhou University
RP Tao, J (corresponding author), Fujian Univ Tradit Chinese Med, Inst Rehabil Ind, Fuzhou, Peoples R China.; Han, X (corresponding author), Fuzhou Univ, Coll Biol Sci & Engn, Fuzhou, Peoples R China.
EM hanxiao@fzu.edu.cn; taojing01@fjtcm.edu.cn
RI han, xiao/CAI-6839-2022; Tao, Jing/GVS-6340-2022; Liang,
   Shengxiang/IXD-8115-2023; Ma, Guannan/JTV-2014-2023
OI Tao, Jing/0000-0002-4895-2065
FU Scientific Research Foundation for the High-level Talents, Fujian
   University of Traditional Chinese Medicine [X2020001]
FX This study was supported by grants from the Scientific Research
   Foundation for the High-level Talents, Fujian University of Traditional
   Chinese Medicine (X2020001-talents).
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TC 7
Z9 7
U1 1
U2 23
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD OCT 8
PY 2021
VL 8
AR 735501
DI 10.3389/fnut.2021.735501
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA WM2KL
UT WOS:000710919600001
PM 34692748
OA Green Published, gold
DA 2025-06-11
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   Cremonini, Eleonora
   Bosi, Cristina
   Magon, Stefania
   Passaro, Angelina
   Bergamini, Carlo M.
   Pilotto, Alberto
   Zuliani, Giovanni
TI Oxidative balance, homocysteine, and uric acid levels in older patients
   with Late Onset Alzheimer's Disease or Vascular Dementia
SO JOURNAL OF THE NEUROLOGICAL SCIENCES
LA English
DT Article
DE Dementia; Homocysteine; Late Onset Alzheimer's Disease; Oxidative
   stress; Uric acid; Vascular Dementia
ID MILD COGNITIVE IMPAIRMENT; PLASMA ANTIOXIDANT STATUS; METABOLIC
   SYNDROME; LIPID-PEROXIDATION; METHYLENETETRAHYDROFOLATE REDUCTASE;
   MITOCHONDRIAL DYSFUNCTION; POSTMENOPAUSAL WOMEN; NADPH OXIDASE;
   RISK-FACTORS; STRESS
AB This study aimed to investigate whether Late Onset Alzheimer's Disease (LOAD) and Vascular Dementia (VAD) might be associated with a distinct profile of oxidative stress (OxS) peripheral markers. Serum levels of hydroperoxides, homocysteine, advanced oxidation protein products, uric add, thiols, and total and residual antioxidant power were assessed in 103 mild cognitive impairment (MCI), 89 LOAD, 54 VAD patients and 48 Controls. Compared with Controls, a similar oxidative unbalance (high hydroperoxides and low residual antioxidant power) was observed in MCI, LOAD and, although less pronounced, VAD. Moreover, individuals with simultaneously high levels of homocysteine and uric acid, both well-known risk factors for cardiovascular disease, had a high probability to be affected by VAD (O.R.:10.50; 95% C.I.: 2.33-47.2), but not LOAD (O.R.: 3.0; 95% C.I.:0.86-10.76) compared with individuals with normal values. Our data suggest that, although they might share a common. OxS-related pathogenesis, VAD and LOAD might maintain some distinctive features, with a predominance of "vascular component" in VAD compared with LOAD. (C) 2013 Elsevier B.V. All rights reserved.
C1 [Cervellati, Carlo; Romani, Arianna; Cremonini, Eleonora; Bergamini, Carlo M.] Univ Ferrara, Dept Biomed & Specialist Surg Sci, Sect Med Biochem Mol Biol & Genet, I-44121 Ferrara, Italy.
   [Seripa, Davide] IRCCS Casa Sollievo Sofferenza, Gerontol & Geriatr Res Lab, I-71013 Foggia, Italy.
   [Bosi, Cristina; Magon, Stefania; Passaro, Angelina; Zuliani, Giovanni] Univ Ferrara, Dept Med Sci, Sect Internal Med Gerontol & Clin Nutr, I-44100 Ferrara, Italy.
   [Pilotto, Alberto] S Antonio Hosp, Azienda ULSS Padova 16, Geriatr Unit, I-35127 Padua, Italy.
C3 University of Ferrara; IRCCS Casa Sollievo Della Sofferenza; University
   of Ferrara; ULSS 6 Euganea; Ospedale Sant'antonio Padova
RP Cervellati, C (corresponding author), Univ Ferrara, Dept Biomed & Specialist Surg Sci, Sect Med Biochem Mol Biol & Genet, Via Luigi Borsari 46, I-44121 Ferrara, Italy.
EM crvcrl@unife.it
RI Seripa, Davide/AAK-1342-2021; Bergamini, Carlo/AAW-6958-2020; Passaro,
   Angelina/P-3401-2015; Cervellati, Carlo/K-6453-2015; Seripa,
   Davide/B-9408-2017; Carlo, Bergamini/K-5664-2016; Romani,
   Arianna/AAY-2434-2021
OI Zuliani, Giovanni/0000-0003-0969-3184; Passaro,
   Angelina/0000-0001-8462-7000; Cervellati, Carlo/0000-0003-4777-6300;
   Seripa, Davide/0000-0001-7331-0470; Carlo,
   Bergamini/0000-0002-9430-8625; Romani, Arianna/0000-0001-8000-6178;
   Bosi, Cristina/0000-0002-9443-1447
FU University of Ferrara
FX The study was only supported by "Local Research Project" grant from
   University of Ferrara.
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NR 56
TC 78
Z9 88
U1 0
U2 27
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0022-510X
EI 1878-5883
J9 J NEUROL SCI
JI J. Neurol. Sci.
PD FEB 15
PY 2014
VL 337
IS 1-2
BP 156
EP 161
DI 10.1016/j.jns.2013.11.041
PG 6
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA AC8TW
UT WOS:000332808700027
PM 24321755
DA 2025-06-11
ER

PT J
AU Mechlinska, A
   Wiglusz, MS
   Slupski, J
   Wlodarczyk, A
   Cubala, WJ
AF Mechlinska, Agnieszka
   Wiglusz, Mariusz S.
   Slupski, Jakub
   Wlodarczyk, Adam
   Cubala, Wieslaw J.
TI Exploring the Relationship between Mood Disorders and Coexisting Health
   Conditions: The Focus on Nutraceuticals
SO BRAIN SCIENCES
LA English
DT Review
DE major depressive disorder; bipolar disorder; nutraceuticals;
   comorbidity; nutritional support
ID MAJOR DEPRESSIVE DISORDER; BIPOLAR DISORDER; DOUBLE-BLIND; METABOLIC
   SYNDROME; VITAMIN-D; HPA AXIS; SUPPLEMENTATION; STRESS; SLEEP;
   METAANALYSIS
AB Major depressive disorder and bipolar disorder are the leading causes of global disability. Approximately 50% of patients fail to attain remission, prompting a pronounced focus on the significance of dietary patterns and specific nutrients within the pathophysiology of mood disorders. The connection between chronic diseases and mood disorders follows a bidirectional pattern: physical ailments are interrelated with affective disorders, and, concurrently, mood symptoms often precede chronic diseases and have the potential to worsen their prognosis. Nutraceuticals affect factors that could potentially impact the onset of mood disorders: monoamines and brain-derived neurotrophic factor (BDNF) concentrations, neuroinflammation, oxidative stress, and sleep quality. Furthermore, mood disorders rarely manifest in isolation. Typically, such patients concurrently experience other mental disorders or somatic comorbidities: obesity, hypertension, diabetes, polycystic ovary syndrome (PCOS), etc., where providing nutritional support is also pertinent. To optimize the therapeutic approach for individuals with mood disorders, incorporating nutritional support may not solely ameliorate symptoms stemming directly from the mental condition, but also indirectly through interventions targeting comorbidities.
C1 [Mechlinska, Agnieszka; Wiglusz, Mariusz S.; Slupski, Jakub; Wlodarczyk, Adam; Cubala, Wieslaw J.] Med Univ Gdansk, Fac Med, Dept Psychiat, Smoluchowskiego 17, PL-80214 Gdansk, Poland.
C3 Fahrenheit Universities; Medical University Gdansk
RP Mechlinska, A (corresponding author), Med Univ Gdansk, Fac Med, Dept Psychiat, Smoluchowskiego 17, PL-80214 Gdansk, Poland.
EM agnieszka.mechlinska@gumed.edu.pl; mwiglusz@gumed.edu.pl;
   jslupski@gumed.edu.pl; adam.wlodarczyk@gumed.edu.pl; ubala@gumed.edu.pl
RI Słupski, Jakub/AAE-5517-2021; Włodarczyk, Adam/AEK-1847-2022; Wiglusz,
   Mariusz/U-8592-2018; Cubala, Wieslaw/N-6113-2018
OI Wlodarczyk, Adam/0000-0001-8549-254X; Cubala,
   Wieslaw/0000-0001-6343-8454; Slupski, Jakub/0000-0002-4579-0208
FU Medical University of Gdansk, Poland [01-10023/0005007/
   01/221/221/0/2023]
FX This work was funded by the Medical University of Gdansk, Poland, grant
   number 01-10023/0005007/ 01/221/221/0/2023.
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NR 102
TC 4
Z9 4
U1 2
U2 6
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3425
J9 BRAIN SCI
JI Brain Sci.
PD SEP
PY 2023
VL 13
IS 9
AR 1262
DI 10.3390/brainsci13091262
PG 17
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA S7TA7
UT WOS:001073145800001
PM 37759862
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Bielka, W
   Przezak, A
AF Bielka, Weronika
   Przezak, Agnieszka
TI The role of FOXO transcription factors in the development of type 2
   diabetes and related potential therapeutic possibilities
SO CLINICAL DIABETOLOGY
LA English
DT Article
DE diabetes; FOXO transcription factors; beta-cell failure; glucose
   metabolism; lipid metabolism; insulin signalling pathway; oxidative
   stress
ID INSULIN SENSITIVITY; GENE-EXPRESSION; HEPATIC GLUCONEOGENESIS;
   ENDOTHELIAL-CELLS; SKELETAL-MUSCLE; LIFE-SPAN; APOC-III; PROTEINS;
   GLUCOSE; ACTIVATION
AB Forkhead box class O (FOXO) family member proteins are key transcription factors for maintaining the intracellular homeostasis in response to changes in the internal and external environment. They participate in the control of such cellular processes as proliferation, cell cycle, apoptosis, glucose and lipid metabolism, and oxidative stress response. Altered expression and activity of these factors are associated with development of metabolic disturbances, primarily type 2 diabetes. Understanding of the role of FOXO in the pathophysiology of these abnormalities will enable appropriate steps to prevent their development and to create therapies targeted at the disturbances underlying type 2 diabetes and metabolic syndrome. In the present article, we summarized the current knowledge about the physiology and pathophysiology of these transcription factors and described their role in the development of diabetes and functioning of various organs. We focused on their role in progression of diabetes and indicated potential targets for future therapeutic interventions.
C1 [Bielka, Weronika; Przezak, Agnieszka] Pomorski Uniwersytet Med, Szczecin, Poland.
C3 Pomeranian Medical University
RP Bielka, W (corresponding author), Pomorski Uniwersytet Med, Szczecin, Poland.
EM weronika.bielka@wp.pl
RI Przezak, Agnieszka/KAL-8902-2024
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NR 72
TC 4
Z9 4
U1 0
U2 4
PU VIA MEDICA
PI GDANSK
PA UL SWIETOKRZYSKA 73, 80-180 GDANSK, POLAND
SN 2450-8187
J9 CLIN DIABETOL
JI Clin. Diabetol.
PY 2021
VL 10
IS 3
BP 290
EP 298
DI 10.5603/DK.a2021.0021
PG 9
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA TI1QA
UT WOS:000672558100009
OA gold
DA 2025-06-11
ER

PT J
AU Wanchai, K
   Pongchaidecha, A
   Chatsudthipong, V
   Chattipakorn, SC
   Chattipakorn, N
   Lungkaphin, A
AF Wanchai, Keerati
   Pongchaidecha, Anchalee
   Chatsudthipong, Varanuj
   Chattipakorn, Siriporn C.
   Chattipakorn, Nipon
   Lungkaphin, Anusorn
TI Role of Gastrointestinal Microbiota on Kidney Injury and the Obese
   Condition
SO AMERICAN JOURNAL OF THE MEDICAL SCIENCES
LA English
DT Review
DE Obesity; Kidney; Gastrointestinal microbiota; Probiotic; Prebiotic
ID DIET-INDUCED OBESITY; LOW-PROTEIN DIET; GUT MICROBIOTA;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; ADIPOSE-TISSUE;
   XYLO-OLIGOSACCHARIDES; METABOLIC SYNDROME; DOUBLE-BLIND; DISEASE
AB Obesity is associated with kidney disease, probably due to obesity-mediated inflammation, podocyte injury and oxidative stress in the kidney It is also linked to other diseases, for example, diabetes and hypertension, which are associated with the development and progression of chronic kidney disease. Interestingly, gastrointestinal dysbiosis has been demonstrated in cases of obesity with the development and progression of kidney disease. Thus, modification of gastrointestinal microbiota using probiotics or prebiotics or both to improve the balance of bacterial flora is a potential approach for the management of obesity-associated kidney disease. This review covers information regarding the association between obesity and kidney injury, and it examines evidence for a hypothesized role of gastrointestinal microbiota in this setting. Studies describing the effects of probiotic and prebiotic treatments on kidney disease show mixed results, although several suggest benefits indicated by biomarkers associated with kidney injury, uremia and inflammation. Additional studies are needed to determine whether these interventions are clinically effective in managing kidney injury and kidney disease.
C1 [Wanchai, Keerati; Pongchaidecha, Anchalee; Chattipakorn, Nipon; Lungkaphin, Anusorn] Chiang Mai Univ, Dept Physiol, Fac Med, Chiang Mai, Thailand.
   [Wanchai, Keerati; Pongchaidecha, Anchalee; Chattipakorn, Siriporn C.; Chattipakorn, Nipon; Lungkaphin, Anusorn] Chiang Mai Univ, Cardiac Electrophysiol Res & Training Ctr, Fac Med, Chiang Mai, Thailand.
   [Chattipakorn, Siriporn C.] Chiang Mai Univ, Dept Oral Biol & Diagnost Sci, Fac Dent, Chiang Mai, Thailand.
   [Wanchai, Keerati] Mae Fah Luang Univ, Sch Med, Chiang Rai, Thailand.
   [Chatsudthipong, Varanuj] Mahidol Univ, Dept Physiol, Fac Sci, Bangkok, Thailand.
C3 Chiang Mai University; Chiang Mai University; Chiang Mai University; Mae
   Fah Luang University; Mahidol University
RP Lungkaphin, A (corresponding author), Chiang Mai Univ, Epithelial Transport & Intracellular Signaling Re, Dept Physiol, Fac Med, Chiang Mai 50200, Thailand.
EM onanusorn@yahoo.com
RI Chattipakorn, Nipon/AAJ-4049-2021
OI Wanchai, Keerati/0000-0003-2282-7909; Chattipakorn,
   Siriporn/0000-0003-1677-7052; Chattipakorn, Nipon/0000-0003-3026-718X
FU Thailand Research Fund, Thailand [RSA5780029]; National Research Council
   of Thailand, Thailand [347682/2560]; CMU Mid-Career Research Fellowship
   program, Thailand [13/2558]; Faculty of Medicine Research Fund, Chiang
   Mai University, Thailand; NSTDA Research Chair grant from the National
   Science and Technology Development Agency, Thailand
FX This work was supported by the Thailand Research Fund, Thailand
   (RSA5780029; A.L.), National Research Council of Thailand, Thailand
   (347682/2560; A.L), CMU Mid-Career Research Fellowship program, Thailand
   (13/2558; A.L.), the Faculty of Medicine Research Fund, Chiang Mai
   University, Thailand (A.L. and A.P.) and the NSTDA Research Chair grant
   from the National Science and Technology Development Agency, Thailand
   (N.C.).
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NR 73
TC 14
Z9 15
U1 0
U2 28
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0002-9629
EI 1538-2990
J9 AM J MED SCI
JI Am. J. Med. Sci.
PD JAN
PY 2017
VL 353
IS 1
BP 59
EP 69
DI 10.1016/j.amjms.2016.11.019
PG 11
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA EO2HE
UT WOS:000396516400011
PM 28104104
DA 2025-06-11
ER

PT J
AU Dongiovanni, P
   Lanti, C
   Riso, P
   Valenti, L
AF Dongiovanni, Paola
   Lanti, Claudia
   Riso, Patrizia
   Valenti, Luca
TI Nutritional therapy for nonalcoholic fatty liver disease
SO JOURNAL OF NUTRITIONAL BIOCHEMISTRY
LA English
DT Review
DE Nonalcoholic fatty liver disease (NAFLD); Food bioactives; Molecular
   mechanisms; In vitro studies; Animal models; Clinical trials
ID RANDOMIZED CONTROLLED-TRIAL; INDUCED HEPATIC STEATOSIS; ACTIVATED
   PROTEIN-KINASE; VITAMIN-D-RECEPTOR; IMPROVES INSULIN-RESISTANCE; INDUCED
   LIPID-ACCUMULATION; EICOSAPENTAENOIC ACID EPA; HEPG2 CELLS; OXIDATIVE
   STRESS; SELENIUM SUPPLEMENTATION
AB Following the epidemics of obesity, nonalcoholic fatty liver disease (NAFLD) has become the leading cause of liver disease in western countries. NAFLD is the hepatic manifestation of metabolic syndrome and may progress to cirrhosis and hepatocellular carcinoma. To date, there are no approved drugs for the treatment of NAFLD, and the main clinical recommendation is lifestyle modification, including increase of physical activity and the adoption of a healthy eating behavior. In this regard, studies aimed to elucidate the effect of dietary interventions and the mechanisms of action of specific food bioactives are urgently needed.
   The present review tries to summarize the most recent data evidencing the effects of nutrients and dietary bioactive compounds intake (i.e., long-chain PUFA, Vitamin E, Vitamin D, minerals and polyphenols) on the modulation of molecular mechanisms leading to fat accumulation, oxidative stress, inflammation and liver fibrosis in NAFLD patients. (C) 2015 Elsevier Inc. All rights reserved.
C1 [Dongiovanni, Paola; Valenti, Luca] Fdn IRCCS Ca Granda Osped Maggiore Policlin, Internal Med & Metab Dis, I-20122 Milan, Italy.
   [Lanti, Claudia; Riso, Patrizia] Univ Milan, Div Human Nutr, Dept Food Environm & Nutr Sci DeFENS, I-20133 Milan, Italy.
   [Valenti, Luca] Univ Milan, Dept Pathophysiol & Transplantat DEPT, I-20122 Milan, Italy.
C3 IRCCS Ca Granda Ospedale Maggiore Policlinico; University of Milan;
   University of Milan
RP Riso, P (corresponding author), Univ Milan, Div Human Nutr, Dept Food Environm & Nutr Sci DeFENS, I-20133 Milan, Italy.
EM Patrizia.riso@unimi.it
RI Riso, Patrizia/AAC-2072-2019; Dongiovanni, Paola/AAC-9965-2019; Valenti,
   Luca/B-3695-2009
OI Dongiovanni, Paola/0000-0003-4343-7213; Valenti,
   Luca/0000-0001-8909-0345; Lanti, Claudia/0000-0003-4354-414X; Riso,
   Patrizia/0000-0002-9204-7257
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NR 169
TC 92
Z9 95
U1 2
U2 45
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0955-2863
EI 1873-4847
J9 J NUTR BIOCHEM
JI J. Nutr. Biochem.
PD MAR
PY 2016
VL 29
BP 1
EP 11
DI 10.1016/j.jnutbio.2015.08.024
PG 11
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA DF9AR
UT WOS:000371653100001
PM 26895659
OA Bronze
DA 2025-06-11
ER

PT J
AU Sánchez-Lozada, LG
   Lanaspa, MA
   Cristóbal-García, M
   García-Arroyo, F
   Soto, V
   Cruz-Robles, D
   Nakagawa, T
   Yu, MA
   Kang, DH
   Johnson, RJ
AF Sanchez-Lozada, Laura Gabriela
   Lanaspa, Miguel A.
   Cristobal-Garcia, Magdalena
   Garcia-Arroyo, Fernando
   Soto, Virgilia
   Cruz-Robles, David
   Nakagawa, Takahiko
   Yu, Min A.
   Kang, Duk-Hee
   Johnson, Richard J.
TI Uric Acid-Induced Endothelial Dysfunction Is Associated with
   Mitochondrial Alterations and Decreased Intracellular ATP Concentrations
SO NEPHRON EXPERIMENTAL NEPHROLOGY
LA English
DT Article
DE Nitric oxide; Mitochondria; Endothelial dysfunction; Uric acid
ID SUGAR-SWEETENED BEVERAGES; METABOLIC SYNDROME; XANTHINE-OXIDASE;
   INHIBITION; CELLS; RISK; ADOLESCENTS; MUSCLE; LIVER
AB Background/Aims: Endothelial dysfunction is associated with mitochondrial alterations. We hypothesized that uric acid (UA), which can induce endothelial dysfunction in vitro and in vivo, might also alter mitochondrial function. Methods: Human aortic endothelial cells were exposed to soluble UA and measurements of oxidative stress, nitric oxide, mitochondrial density, ATP production, aconitase-2 and enoyl Co-A hydratase-1 expressions, and aconitase-2 activity in isolated mitochondria were determined. The effect of hyperuricemia induced by uricase inhibition in rats on renal mitochondrial integrity was also assessed. Results: UA-induced endothelial dysfunction was associated with reduced mitochondrial mass and ATP production. UA also decreased aconitase-2 activity and lowered enoyl CoA hydratase-1 expression. Hyperuricemic rats showed increased mitDNA damage in association with higher levels of intrarenal UA and oxidative stress. Conclusions: UA-induced endothelial dysfunction is associated with mitochondrial alterations and decreased intracellular ATP. These studies provide additional evidence for a deleterious effect of UA on vascular function that could be important in the pathogenesis of hypertension and vascular disease. Copyright (c) 2012 S. Karger AG, Basel
C1 [Sanchez-Lozada, Laura Gabriela; Cristobal-Garcia, Magdalena; Garcia-Arroyo, Fernando; Nakagawa, Takahiko] INC Ignacio Chavez, Lab Renal Physiopathol, Mexico City 14080, DF, Mexico.
   [Sanchez-Lozada, Laura Gabriela; Cristobal-Garcia, Magdalena; Garcia-Arroyo, Fernando; Nakagawa, Takahiko] INC Ignacio Chavez, Dept Nephrol, Mexico City 14080, DF, Mexico.
   [Soto, Virgilia] INC Ignacio Chavez, Dept Pathol, Mexico City 14080, DF, Mexico.
   [Cruz-Robles, David] INC Ignacio Chavez, Dept Mol Biol, Mexico City 14080, DF, Mexico.
   [Sanchez-Lozada, Laura Gabriela; Lanaspa, Miguel A.; Johnson, Richard J.] Univ Colorado, Div Renal Dis & Hypertens, Denver, CO 80202 USA.
   [Yu, Min A.; Kang, Duk-Hee] Ewha Womans Univ, Sch Med, Ewha Med Res Ctr, Dept Internal Med,Div Nephrol, Seoul, South Korea.
C3 University of Colorado System; University of Colorado Denver; Ewha
   Womans University
RP Sánchez-Lozada, LG (corresponding author), INC Ignacio Chavez, Lab Renal Physiopathol, Juan Badiano 1, Mexico City 14080, DF, Mexico.
EM lgsanchezlozada@gmail.com
RI YU, MA/JTU-4901-2023; Sanchez-Lozada, Laura/AAS-2104-2021; Lanaspa,
   Miguel/AAO-4971-2020; Cruz-Robles, David/C-7278-2015
OI Garcia Arroyo, Fernando Enrique/0000-0003-1545-9765; Cruz-Robles,
   David/0000-0003-4234-9561; Sanchez-Lozada,
   Laura-Gabriela/0000-0003-0348-9617
FU NIH [HL-68607, DK-90859]; Korea Healthcare Technology R&D Project,
   Ministry of Health, Welfare and Family Affairs, Republic of Korea
   [A101742]; National Council of Science and Technology (CONACyT) Mexico
   [081054, 0133232]
FX Support for this paper was provided by NIH grants HL-68607 and DK-90859,
   Korea Healthcare Technology R&D Project, Ministry of Health, Welfare and
   Family Affairs, Republic of Korea grant A101742, and National Council of
   Science and Technology (CONACyT) Mexico grants 081054 and 0133232. We
   thank Benito Chavez-Renteria for processing the renal sections for
   histological evaluation.
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TC 247
Z9 270
U1 2
U2 25
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1660-2129
J9 NEPHRON EXP NEPHROL
JI Nephron Exp. Nephrol
PY 2012
VL 121
IS 3-4
BP E71
EP E78
DI 10.1159/000345509
PG 8
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 132JO
UT WOS:000318063900002
PM 23235493
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Tsai, CY
   Shen, CY
   Liao, HT
   Li, KJ
   Lee, HT
   Lu, CS
   Wu, CH
   Kuo, YM
   Hsieh, SC
   Yu, CL
AF Tsai, Chang-Youh
   Shen, Chieh-Yu
   Liao, Hsien-Tzung
   Li, Ko-Jen
   Lee, Hui-Ting
   Lu, Cheng-Shiun
   Wu, Cheng-Han
   Kuo, Yu-Min
   Hsieh, Song-Chou
   Yu, Chia-Li
TI Molecular and Cellular Bases of Immunosenescence, Inflammation, and
   Cardiovascular Complications Mimicking "Inflammaging" in Patients with
   Systemic Lupus Erythematosus
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE systemic lupus erythematosus; immunosenescence; inflammaging; oxidative
   stress; nitrosative stress; bioenergetics; immunometabolism; advanced
   glycation end product
ID GLYCATION END-PRODUCTS; BLOOD MONONUCLEAR-CELLS; INNATE IMMUNE-SYSTEM;
   OXIDATIVE STRESS; T-CELLS; MITOCHONDRIAL-DNA; TELOMERASE ACTIVITY;
   PEROXYNITRITE IMPLICATIONS; SKIN AUTOFLUORESCENCE; SIGNAL-TRANSDUCTION
AB Systemic lupus erythematosus (SLE) is an archetype of systemic autoimmune disease, characterized by the presence of diverse autoantibodies and chronic inflammation. There are multiple factors involved in lupus pathogenesis, including genetic/epigenetic predisposition, sexual hormone imbalance, environmental stimulants, mental/psychological stresses, and undefined events. Recently, many authors noted that inflammaging, consisting of immunosenescence and inflammation, is a common feature in aging people and patients with SLE. It is conceivable that chronic oxidative stresses originating from mitochondrial dysfunction, defective bioenergetics, abnormal immunometabolism, and premature telomere erosion may accelerate immune cell senescence in patients with SLE. The mitochondrial dysfunctions in SLE have been extensively investigated in recent years. The molecular basis of normoglycemic metabolic syndrome has been found to be relevant to the production of advanced glycosylated and nitrosative end products. Besides, immunosenescence, autoimmunity, endothelial cell damage, and decreased tissue regeneration could be the results of premature telomere erosion in patients with SLE. Herein, the molecular and cellular bases of inflammaging and cardiovascular complications in SLE patients will be extensively reviewed from the aspects of mitochondrial dysfunctions, abnormal bioenergetics/immunometabolism, and telomere/telomerase disequilibrium.
C1 [Tsai, Chang-Youh; Liao, Hsien-Tzung] Taipei Vet Gen Hosp, Div Allergy Immunol & Rheumatol, 201 Sec 2,Shih Pai Rd, Taipei 11217, Taiwan.
   [Tsai, Chang-Youh; Liao, Hsien-Tzung] Natl Yang Ming Univ, 201 Sec 2,Shih Pai Rd, Taipei 11217, Taiwan.
   [Shen, Chieh-Yu; Lu, Cheng-Shiun; Wu, Cheng-Han; Kuo, Yu-Min] Natl Taiwan Univ, Inst Clin Med, Coll Med, 7 Chung Shan South Rd, Taipei 10002, Taiwan.
   [Shen, Chieh-Yu; Li, Ko-Jen; Lu, Cheng-Shiun; Wu, Cheng-Han; Kuo, Yu-Min; Hsieh, Song-Chou; Yu, Chia-Li] Natl Taiwan Univ Hosp, Dept Internal Med, 7 Chung Shan South Rd, Taipei 10002, Taiwan.
   [Lee, Hui-Ting] MacKay Mem Hosp, Sect Allergy Immunol & Rheumatol, 92 Sect 2,Chung Shan North Rd, Taipei 10449, Taiwan.
C3 Taipei Veterans General Hospital; National Yang Ming Chiao Tung
   University; National Taiwan University; National Taiwan University;
   National Taiwan University Hospital; Mackay Memorial Hospital
RP Yu, CL (corresponding author), Natl Taiwan Univ Hosp, Dept Internal Med, 7 Chung Shan South Rd, Taipei 10002, Taiwan.
EM chialiyu@ntu.edu.tw
RI Tsai, Chang-Youh/IZD-5962-2023; Shen, Chiehyu/JVE-1092-2024; Wu,
   Chenghan/JMQ-2691-2023; Tsai, Chang-Youh/G-1747-2013
OI Shen, Chieh-Yu/0000-0002-3218-0689; YU, CHIA-LI/0000-0003-4988-0400;
   /0000-0002-4794-9438; Tsai, Chang-Youh/0000-0002-4154-4018; LI,
   KO-JEN/0000-0002-4544-4620
FU Ministry of Science and Technology, Taiwan
   [MOST-107-2314-B-075-051-MY3]; Taipen Veterans General Hospital, Taiwan
   [V108C-203, v107D37-002-MY3]; Executive Yuan, Taiwan
FX This work is supported partly by the grants from the Ministry of Science
   and Technology (MOST-107-2314-B-075-051-MY3), Executive Yuan, and Taipen
   Veterans General Hospital (V108C-203 and v107D37-002-MY3), Taiwan.
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NR 139
TC 34
Z9 35
U1 0
U2 9
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD AUG 2
PY 2019
VL 20
IS 16
AR 3878
DI 10.3390/ijms20163878
PG 20
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA IV6XM
UT WOS:000484411100035
PM 31395799
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Kilic, A
   Yorulmaz, A
   Erdogan, S
   Cakmak, SK
   Guney, E
   Sens, O
   Erel, O
AF Kilic, Arzu
   Yorulmaz, Ahu
   Erdogan, Serpil
   Cakmak, Seray Kulcu
   Guney, Elif
   Sens, Orhan
   Erel, Ozcan
TI An evaluation of thiol/disulphide homeostasis in patients with psoriasis
SO POSTEPY DERMATOLOGII I ALERGOLOGII
LA English
DT Article
DE psoriasis; thiol/disulphide homeostasis; dyslipidemia
ID OXIDATIVE STRESS; SINGLET OXYGEN; DISEASE; REDOX; DIFFERENTIATION;
   GLUTATHIONE; APOPTOSIS; INDUCERS; CELLS
AB Introduction: The role of oxidative stress in the pathogenesis of psoriasis has been investigated in previous studies with conflicting results. On the other hand, well-established treatments currently used in psoriasis exert their effects via a boost of oxidative stress. Recently, a strong positive association between psoriasis, metabolic syndrome and dyslipidemia has also been described showing the complex nature of the disease.
   Aim: To examine thiol/disulphide homeostasis, a newly developed homeostasis assay in psoriasis and evaluate the possible association between thiol/disulphide homeostasis and dyslipidemia in psoriasis.
   Material and methods: The study population included 92 psoriasis patients and 71 healthy subjects. Serum native thiol, total thiol and disulphide levels were investigated in patients with psoriasis and in healthy subjects. In addition, lipid profile (serum total cholesterol, triglyceride, high-density lipoprotein cholesterol and low-density lipoprotein cholesterol) levels were investigated in both groups. The association between thiol-disulphide parameters and dyslipidemia was also evaluated.
   Results: Serum total cholesterol and triglyceride levels were found to be higher in patients with psoriasis than in the healthy group. Lower plasma disulphide and higher native thiol levels were found in patients with psoriasis indicating an antioxidant status.
   Conclusions: To our knowledge, this is the first study showing the shift of dynamic thiol/disulphide homeostasis towards the thiol form in psoriasis which indicate higher antioxidant status.
C1 [Kilic, Arzu] Balikesir Univ, Med Fac, Dept Dermatol, TR-10100 Balikesir, Turkey.
   [Yorulmaz, Ahu; Cakmak, Seray Kulcu] Ankara Numune Training & Res Hosp, Dept Dermatol, Ankara, Turkey.
   [Erdogan, Serpil] Ankara Ataturk Educ & Res Hosp, Dept Biochem, Ankara, Turkey.
   [Guney, Elif] Yuksek Ihtisas Educ & Res Hosp, Biochem Clin, Ankara, Turkey.
   [Sens, Orhan; Erel, Ozcan] Ankara Ataturk Educ & Res Hosp, Biochem Clin, Ankara, Turkey.
C3 Balikesir University; Ankara Numune Training & Research Hospital; Ankara
   Ataturk Training & Research Hospital; Turkey Specialized Higher
   Education & Research Hospital; Yuksek Ihtisas Training & Research
   Hospital; Ankara Ataturk Training & Research Hospital
RP Kilic, A (corresponding author), Balikesir Univ, Med Fac, Dept Dermatol, TR-10100 Balikesir, Turkey.
EM kilicarzu@gmail.com
RI EREL, Ozcan/U-1008-2019; Külcü Çakmak, Seray/IZD-8100-2023; Yorulmaz,
   Ahu/AAE-8814-2020
OI Yorulmaz, Ahu/0000-0003-4687-0522; Kulcu Cakmak,
   Seray/0000-0001-8536-5946
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NR 36
TC 12
Z9 12
U1 0
U2 0
PU TERMEDIA PUBLISHING HOUSE LTD
PI POZNAN
PA KLEEBERGA ST 2, POZNAN, 61-615, POLAND
SN 1642-395X
J9 POSTEP DERM ALERGOL
JI Postep. Dermatol. Alergol.
PY 2017
VL 34
IS 5
BP 464
EP 467
DI 10.5114/ada.2017.71113
PG 4
WC Allergy; Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Allergy; Dermatology
GA FN8RE
UT WOS:000416292400010
PM 29507562
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Larose, J
   Julien, P
   Greffard, K
   Fraser, WD
   Audibert, F
   Wei, SQ
   Bilodeau, JF
AF Larose, Jessica
   Julien, Pierre
   Greffard, Karine
   Fraser, William D.
   Audibert, Francois
   Wei, Shu Qin
   Bilodeau, Jean-Francois
TI F2-isoprostanes are correlated with trans fatty acids
   in the plasma of pregnant women
SO PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
LA English
DT Article
DE Elaidic acid; Oxidative stress; Pregnancy; Mass spectrometry; Vaccenic
   acid; 8-iso-PGF(2 alpha)
ID CONJUGATED LINOLEIC-ACID; CORONARY-HEART-DISEASE; OXIDATIVE STRESS;
   SYSTEMIC INFLAMMATION; LIPID-PEROXIDATION; ENDOTHELIAL DYSFUNCTION;
   CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; MASS-SPECTROMETRY;
   ARACHIDONIC-ACID
AB We hypothesized that the mild physiological oxidative stress present during pregnancy could increase both, plasma F-2-isoprostanes (F-2-isoPs) by lipid oxidation and trans fatty acids (TFA) through cis-trans isomerization respectively. Plasma samples collected at 12-18 weeks (MIROS cohort; n=65) and 38-41 weeks of pregnancy (CHUL cohort; n=21) were subjected to alkaline hydrolysis followed by liquid-liquid extraction in order to extract total F-2-isoPs for quantification by HPLC-MS/MS. Several positive correlations were found between F-2-isoPs and TFA, measured by GC-FID in plasma phospholipids, such as 6t-18:1, 9t-18:1 and 9t,12c-18:2 (r > 0306; p < 0.045). Despite its low level, the 9t,12c-18:2 trans isomer, known to be associated to cardiovascular diseases, showed the most significant correlations with F-2-isoPs. No correlation was observed between F-2-isoPs and 9t-16:1 or 11 t-18:1. In summary, this study suggests either a concomitant phenomenon or a competition between lipid peroxidation and cis-trans isomerisation of the cis precursor fatty acid in vivo during pregnancy. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Larose, Jessica; Julien, Pierre; Greffard, Karine; Bilodeau, Jean-Francois] CRCHU Quebec, Quebec City, PQ, Canada.
   [Julien, Pierre; Greffard, Karine] Univ Laval, CREMOGH, Quebec City, PQ, Canada.
   [Fraser, William D.; Audibert, Francois; Wei, Shu Qin] CHU St Justine, Dept Obstet & Gynecol, Montreal, PQ, Canada.
   [Fraser, William D.; Audibert, Francois; Wei, Shu Qin] Univ Montreal, Montreal, PQ, Canada.
   [Julien, Pierre] Univ Laval, Fac Med, Dept Med, Quebec City, PQ, Canada.
   [Bilodeau, Jean-Francois] Univ Laval, Fac Med, Dept Obstetr Gynecol & Reprod, Quebec City, PQ, Canada.
C3 Laval University; Universite de Montreal; Centre Hospitalier
   Universitaire Sainte-Justine; Universite de Montreal; Laval University;
   Laval University
RP Bilodeau, JF (corresponding author), CHU Quebec, Ctr Rech, Quebec City, PQ G1V 4G2, Canada.
EM jean-francois.bilodeau@crchudequebec.ulaval.ca
RI Audibert, François/AAL-1265-2020; Julien, Pierre/AGO-7542-2022;
   Bilodeau, Jean-François/B-1712-2013
OI Audibert, Francois/0000-0002-2697-3826; Bilodeau,
   Jean-Francois/0000-0001-9427-5387
FU Canadian Institutes of Health Research (CIHR) [84219, 78879]; MIROS
   cohort; Fonds de Recherche en Sante du Quebec (FRSQ) awards
FX The authors would like to thank Ms. Line Berthiaume and M. Francois
   Cadelis for their help with the extraction of fatty acids. This work was
   supported by grants from the Canadian Institutes of Health Research
   (CIHR, Grant nos. 84219 to J.-F.B and 78879 to W.D.F. and P.J. for the
   MIROS cohort). Jessica Larose and Shu Qin Wei were recipients of Fonds
   de Recherche en Sante du Quebec (FRSQ) awards.
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NR 56
TC 16
Z9 17
U1 0
U2 15
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0952-3278
EI 1532-2823
J9 PROSTAG LEUKOTR ESS
JI Prostaglandins Leukot. Essent. Fatty Acids
PD DEC
PY 2014
VL 91
IS 6
BP 243
EP 249
DI 10.1016/j.plefa.2014.09.010
PG 7
WC Biochemistry & Molecular Biology; Cell Biology; Endocrinology &
   Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology; Endocrinology &
   Metabolism
GA AU7UJ
UT WOS:000345806400002
PM 25312493
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Fernald, LCH
   Jones-Smith, JC
   Ozer, EJ
   Neufeld, LM
   DiGirolamo, AM
AF Fernald, Lia C. H.
   Jones-Smith, Jessica C.
   Ozer, Emily J.
   Neufeld, Lynnette M.
   DiGirolamo, Ann M.
TI Maternal Depressive Symptoms and Physical Activity in Very Low-income
   Children
SO JOURNAL OF DEVELOPMENTAL AND BEHAVIORAL PEDIATRICS
LA English
DT Article
DE poverty; nutrition transition; depression; physical activity
ID SOCIOECONOMIC-STATUS; METABOLIC SYNDROME; BEHAVIOR PROBLEMS; BIRTH SIZE;
   CES-D; OVERWEIGHT; FITNESS; MEXICO; RISK; ASSOCIATION
AB Objective: To test the contribution of maternal depression during late infancy to physical activity in children 5 years later. Method: Children (n = 168) from very low-income households in semiurban Mexico were assessed as toddlers (IS months, Time 1) and at pre-school age (4-6 years, Time 2). Child low activity level (<20 minutes of activity daily for <7 d/wk) at Time 2 was the primary outcome measure and maternal depressive symptoms (Center for Epidemiologic Studies-Depression Scale) by self-report at Time I was the primary independent variable. Covariates tested included child age, sex, BMI percentile, television viewing and behavior (Behavior Problem index subscales), current maternal depressive symptoms, age, BMI and physical activity level, and family socioeconomic status; all covariates were assessed at Time 2 except for socioeconomic status. Results: At 4 to 6 years old, 27.5% of children were categorized with low activity level. Exposure to high maternal depressive symptoms at child age 15 months was associated with an increased risk of having a low activity level at age 4 to 6 years (OR, 2.38; 95% Cl, 1.05-5.40); results were unchanged with the inclusion of current maternal depressive symptoms. High child TV viewing was significantly associated with low activity level (OR, 5.44; 95% Cl, 2.06-14.3), but did not change the effect of maternal depressive symptoms in early childhood. Tests of mediation revealed that current child internalizing behavior, but not externalizing behavior, significantly attenuated the association between early high maternal depressive symptoms and later childhood activity level. Conclusion: Exposure to maternal depressive symptoms in late infancy is a risk factor for low activity level in later childhood and the association may be mediated by child internalizing factors.
C1 [Fernald, Lia C. H.; Ozer, Emily J.] Univ Calif Berkeley, Sch Publ Hlth, Community Hlth & Human Dev, Berkeley, CA 94720 USA.
   [Jones-Smith, Jessica C.] Univ N Carolina, Carolina Populat Ctr, Chapel Hill, NC USA.
   [Neufeld, Lynnette M.; DiGirolamo, Ann M.] Inst Nacl Salud Publ, Div Nutr Epidemiol, Cuernavaca, Morelos, Mexico.
   [Neufeld, Lynnette M.; DiGirolamo, Ann M.] Emory Univ, Sch Publ Hlth, Hubert Dept Global Hlth, Atlanta, GA USA.
C3 University of California System; University of California Berkeley;
   University of North Carolina; University of North Carolina Chapel Hill;
   Instituto Nacional de Salud Publica; Emory University
RP Fernald, LCH (corresponding author), Univ Calif Berkeley, Sch Publ Hlth, Community Hlth & Human Dev, 50 Univ Hall,MC 7360, Berkeley, CA 94720 USA.
EM fernald@berkeley.edu
OI Fernald, Lia C.H./0000-0003-1555-4607; Jones-Smith,
   Jessica/0000-0001-8962-1695
FU NIMH [R21 MH70950]; Fogarty International Center [K01 TW00013];
   Micronutrient Initiative [5500-0003-31-300]; National Council for
   Science and Technology (CONACyT); Mexican Government
FX We gratefully acknowledge the contributions of Reynaldo Martorell, PhD
   (Emory University) and Usba Ramakrishnan, PhD (Emory University) to
   initial study design and foor allowing us to use data from the original
   trial. We thank Raquel Garcia Feregrino for overseeing data collection
   for this study. We also thank the families who participated in the
   research. This study was supported by the Berkely Consortium on
   Population Health, which received funding from NIMH (R21 MH70950, P1 Tom
   Boyce). Earlier data collection was supported by the Fogarty
   International Center (K01 TW00013), the Micronutrient Initiative
   (5500-0003-31-300), the National Council for Science and Technology
   (CONACyT), and the Mexican Government.
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NR 66
TC 21
Z9 29
U1 1
U2 20
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0196-206X
EI 1536-7312
J9 J DEV BEHAV PEDIATR
JI J. Dev. Behav. Pediatr.
PD OCT
PY 2008
VL 29
IS 5
BP 385
EP 393
DI 10.1097/DBP.0b013e318182a98e
PG 9
WC Behavioral Sciences; Psychology, Developmental; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Behavioral Sciences; Psychology; Pediatrics
GA 361SN
UT WOS:000260147500009
PM 18714208
OA Green Accepted, Green Submitted
DA 2025-06-11
ER

PT J
AU Huang, XJ
   Chen, HL
   Wen, S
   Dong, MY
   Zhou, LG
   Yuan, XL
AF Huang, Xiaojing
   Chen, Huiling
   Wen, Song
   Dong, Meiyuan
   Zhou, Ligang
   Yuan, Xinlu
TI Therapeutic Approaches for Nonalcoholic Fatty Liver Disease: Established
   Targets and Drugs
SO DIABETES METABOLIC SYNDROME AND OBESITY
LA English
DT Review
DE non-alcoholic fatty liver disease; oxidative stress; lipotoxicity; organ
   dysfunction; dysbiosis; new treatment modalities
ID TYPE-2 DIABETES-MELLITUS; CARDIOVASCULAR EVENTS; SELECTIVE INHIBITOR;
   PEPTIDE-1 RECEPTOR; OBETICHOLIC ACID; STEATOHEPATITIS; INFLAMMATION;
   STEATOSIS; OBESITY; LIPOTOXICITY
AB Nonalcoholic fatty liver disease (NAFLD), as a multisystemic disease, is the most prevalent chronic liver disease characterized by extremely complex pathogenic mechanisms and multifactorial etiology, which often develops as a consequence of obesity, metabolic syndrome. Pathophysiological mechanisms involved in the development of NAFLD include diet, obesity, insulin resistance (IR), genetic and epigenetic determinants, intestinal dysbiosis, oxidative/nitrosative stress, autophagy dysregulation, hepatic inflammation, gut-liver axis, gut microbes, impaired mitochondrial metabolism and regulation of hepatic lipid metabolism. Some of the new drugs for the treatment of NAFLD are introduced here. All of them achieve therapeutic objectives by interfering with certain pathophysiological pathways of NAFLD, including fibroblast growth factors (FGF) analogues, peroxisome proliferator-activated receptors (PPARs) agonists, glucagon-like peptide-1 (GLP-1) agonists, G protein-coupled receptors (GPCRs), sodium-glucose cotransporter-2 inhibitors (SGLT-2i), farnesoid X receptor (FXR), fatty acid synthase inhibitor (FASNi), antioxidants, etc. This review describes some pathophysiological mechanisms of NAFLD and established targets and drugs.
C1 [Huang, Xiaojing] Fudan Univ, Grad Sch, Shanghai, Peoples R China.
   [Huang, Xiaojing; Chen, Huiling; Wen, Song; Dong, Meiyuan; Zhou, Ligang; Yuan, Xinlu] Fudan Univ, Shanghai Pudong Hosp, Dept Endocrinol, Pudong Med Ctr, Shanghai, Peoples R China.
C3 Fudan University; Fudan University
RP Yuan, XL (corresponding author), Fudan Univ, Shanghai Pudong Hosp, Dept Endocrinol, Pudong Med Ctr, Shanghai, Peoples R China.
EM yuanxinlu1982@126.com
RI Dong, Meiyuan/ADB-7555-2022
OI Chen, Huiling/0009-0008-9615-7120; Wen, Song/0000-0001-6173-0507
FU Talents Training Program of Pudong Hospital affiliated to Fudan
   University [PJ202001]; National Natural Science Foundation of China
   [82100850]; Project of Key Medical Specialty of Pudong Hospital of Fudan
   University [Tszb2023-14]; Scientific Program of Shanghai Pudong Hospital
   [YJRCJJ201808]
FX Funding This work was supported by Talents Training Program of Pudong
   Hospital affiliated to Fudan University (PJ202001) , National Natural
   Science Foundation of China (82100850) , the Project of Key Medical
   Specialty of Pudong Hospital of Fudan University (No Tszb2023-14) and
   Scientific Program of Shanghai Pudong Hospital (YJRCJJ201808) .
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NR 92
TC 6
Z9 6
U1 5
U2 14
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-7007
J9 DIABET METAB SYND OB
JI Diabetes Metab. Syndr. Obes.
PY 2023
VL 16
BP 1809
EP 1819
DI 10.2147/DMSO.S411400
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA K4ZZ1
UT WOS:001016551000001
PM 37366486
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Morine, MJ
   Tierney, AC
   van Ommen, B
   Daniel, H
   Toomey, S
   Gjelstad, IMF
   Gormley, IC
   Pérez-Martinez, P
   Drevon, CA
   López-Miranda, J
   Roche, HM
AF Morine, Melissa J.
   Tierney, Audrey C.
   van Ommen, Ben
   Daniel, Hannelore
   Toomey, Sinead
   Gjelstad, Ingrid M. F.
   Gormley, Isobel C.
   Perez-Martinez, Pablo
   Drevon, Christian A.
   Lopez-Miranda, Jose
   Roche, Helen M.
TI Transcriptomic Coordination in the Human Metabolic Network Reveals Links
   between n-3 Fat Intake, Adipose Tissue Gene Expression and Metabolic
   Health
SO PLOS COMPUTATIONAL BIOLOGY
LA English
DT Article
ID ACTIVATED RECEPTOR-GAMMA; ADIPOCYTE DIFFERENTIATION; PPAR-GAMMA;
   OMEGA-3-FATTY-ACIDS; F-2-ISOPROSTANES; SUPPLEMENTATION; INTERVENTION;
   DISEASES; LIPGENE; WEIGHT
AB Understanding the molecular link between diet and health is a key goal in nutritional systems biology. As an alternative to pathway analysis, we have developed a joint multivariate and network-based approach to analysis of a dataset of habitual dietary records, adipose tissue transcriptomics and comprehensive plasma marker profiles from human volunteers with the Metabolic Syndrome. With this approach we identified prominent co-expressed sub-networks in the global metabolic network, which showed correlated expression with habitual n-3 PUFA intake and urinary levels of the oxidative stress marker 8-iso-PGF(2 alpha). These sub-networks illustrated inherent cross-talk between distinct metabolic pathways, such as between triglyceride metabolism and production of lipid signalling molecules. In a parallel promoter analysis, we identified several adipogenic transcription factors as potential transcriptional regulators associated with habitual n-3 PUFA intake. Our results illustrate advantages of network-based analysis, and generate novel hypotheses on the transcriptomic link between habitual n-3 PUFA intake, adipose tissue function and oxidative stress.
C1 [Morine, Melissa J.; Tierney, Audrey C.; Toomey, Sinead; Roche, Helen M.] Univ Coll Dublin, UCD Conway Inst, Nutrigen Res Grp, Dublin 2, Ireland.
   [van Ommen, Ben] TNO Qual Life, Zeist, Netherlands.
   [Daniel, Hannelore] Tech Univ Munich, Ctr Life & Food Sci, Mol Nutr Unit, D-8050 Freising Weihenstephan, Germany.
   [Gjelstad, Ingrid M. F.; Drevon, Christian A.] Univ Oslo, Inst Basic Med Sci, Fac Med, Dept Nutr, Oslo, Norway.
   [Gjelstad, Ingrid M. F.] Oslo Univ Hosp, Dept Endocrinol, Oslo, Norway.
   [Gormley, Isobel C.] Univ Coll Dublin, Sch Math Sci, Dublin 2, Ireland.
   [Perez-Martinez, Pablo; Lopez-Miranda, Jose] Univ Cordoba, Reina Sofia Univ Hosp, Maimonides Inst Biomed Res Cordoba IMIBIC,Lipids, Inst Salud Carlos III,Ciber Phyisiopatol Obes & N, Cordoba, Spain.
C3 University College Dublin; Netherlands Organization Applied Science
   Research; Technical University of Munich; University of Oslo; University
   of Oslo; University College Dublin; Hospital Universitario Reina Sofia -
   Cordoba; Instituto de Salud Carlos III; Universidad de Cordoba
RP Morine, MJ (corresponding author), Univ Coll Dublin, UCD Conway Inst, Nutrigen Res Grp, Dublin 2, Ireland.
EM helen.roche@ucd.ie
RI Tierney, Audrey/AAB-7068-2022; Lopez-Miranda, Jose/Y-8306-2019; Roche,
   Helen/AAF-4164-2019; Drevon, Christian/F-6012-2010; Daniel,
   Hannelore/B-8982-2009; Gormley, Isobel Claire/F-7089-2016; Perez
   Martinez, Pablo/AEL-6176-2022
OI Tierney, Audrey/0000-0001-8562-2877; Lopez-Miranda,
   Jose/0000-0002-8844-0718; Roche, Helen/0000-0002-0628-3318; Gormley,
   Isobel Claire/0000-0001-7713-681X; Perez Martinez,
   Pablo/0000-0001-7716-8117; Toomey, Sinead/0000-0002-1365-8173
FU EU [FOOD-2003-CT-505944]; The European Nutrigenomics Organisation
   [FP6-506360]; Johan Throne Holst Foundation for Nutrition Research and
   Freia Medical Research, Norway; Spanish Ministry of Science and
   Innovation [AGL2006-01979/ALI, AGL2009-12270]; IRCSET; Science
   Foundation Ireland [06/IM.1/B105]
FX This work was supported by EU FP6 Food Safety & Quality Programme,
   LIPGENE (FOOD-2003-CT-505944), The European Nutrigenomics Organisation
   (FP6-506360), Johan Throne Holst Foundation for Nutrition Research and
   Freia Medical Research Fund, Norway, and grants from the Spanish
   Ministry of Science and Innovation (AGL2006-01979/ALI, AGL2009-12270 to
   JLM). MJM was supported by the IRCSET postgraduate scholarship scheme.
   HMR was supported by Science Foundation Ireland PI Programme
   (06/IM.1/B105). The funders had no role in study design, data collection
   and analysis, decision to publish, or preparation of the manuscript.
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NR 47
TC 30
Z9 32
U1 0
U2 10
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
EI 1553-7358
J9 PLOS COMPUT BIOL
JI PLoS Comput. Biol.
PD NOV
PY 2011
VL 7
IS 11
AR e1002223
DI 10.1371/journal.pcbi.1002223
PG 10
WC Biochemical Research Methods; Mathematical & Computational Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Mathematical & Computational Biology
GA 851JG
UT WOS:000297263700004
PM 22072950
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Krawczyk, M
   Bonfrate, L
   Portincasa, P
AF Krawczyk, Marcin
   Bonfrate, Leonilde
   Portincasa, Piero
TI Nonalcoholic fatty liver disease
SO BEST PRACTICE & RESEARCH CLINICAL GASTROENTEROLOGY
LA English
DT Article
DE Fatty acids; Hepatic steatosis; Insulin resistance; Metabolic syndrome;
   Mitochondrial dysfunction; Visceral adiposity
ID INCREASED INTESTINAL PERMEABILITY; TOTAL PARENTERAL-NUTRITION;
   PLACEBO-CONTROLLED TRIAL; OBSTRUCTIVE SLEEP-APNEA;
   NECROSIS-FACTOR-ALPHA; VITAMIN-E TREATMENT; INSULIN-RESISTANCE; HEPATIC
   STEATOSIS; OXIDATIVE STRESS; LONG-TERM
AB Non-alcoholic fatty liver disease (NAFLD) the most common liver disorder in the Western world is a climco-histopathological entity in which excessive triglyceride accumulation in the liver occurs Non-alcoholic steatohepatitis (NASH) represents the necroinflammatory form which can lead to advanced liver fibrosis cirrhosis and hepatocellular carcinoma The pathogenesis of NAFLD/NASH is complex but Increased visceral adiposity plus insulin resistance with increased free fatty acids release play an initial key role for the onset and perpetuation of liver steatosis Further events in the liver include oxidative stress and lipid peroxidation decreased antioxidant defences early mitochondrial dysfunction iron accumulation unbalance of adipose-derived adipokines with a chronic proinflammatory status and gut-derived microbial adducts New gene polymorphisms increasing the risk of fatty liver namely APOC3 and PNPLA3 have been lately identified allowing further insights into the pathogenesis of this condition In our review pathophysiological genetic, and essential diagnostic and therapeutic aspects of NAFLD are examined with future trends in this field highlighted (C) 2010 Elsevier Ltd All rights reserved
C1 [Bonfrate, Leonilde; Portincasa, Piero] Univ Bari, Dept Internal Med & Publ Med DIMIMP, Clin Med A Murri, I-70121 Bari, Italy.
   [Krawczyk, Marcin] Saarland Univ Hosp, Dept Med 2, Homburg, Germany.
C3 Universita degli Studi di Bari Aldo Moro; Universitatsklinikum des
   Saarlandes
RP Portincasa, P (corresponding author), Univ Med Sch Bari, Dept Internal Med & Publ Med DIMIMP, Clin Med A Murri, Piazza Giulio Cesare 11 Policlin, I-70124 Bari, Italy.
RI Krawczyk, Marcin/AAG-4356-2020; Bonfrate, Leonilde/ABH-1835-2021;
   portincasa, piero/J-7245-2018
OI portincasa, piero/0000-0001-5359-1471
FU Italian Ministry of University and Research [RBAU01RANB002]; Italian
   National Research Council (CNR); University of Ban [ORBA09XZZT,
   ORBA08YHKX]; Deutsche Forschungsgemeinschaft [SFB/TRR 57]
FX The work was supported in part by research grants from the Italian
   Ministry of University and Research (FIRB 2003 RBAU01RANB002), the
   Italian National Research Council (CNR) (short-term mobility grant 2005)
   the University of Ban (grants ORBA09XZZT, ORBA08YHKX) (PP) and Deutsche
   Forschungsgemeinschaft (SFB/TRR 57) (M K)
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NR 168
TC 151
Z9 171
U1 0
U2 24
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1521-6918
EI 1532-1916
J9 BEST PRACT RES CL GA
JI Best Pract. Res. Clin. Gastroenterol.
PD OCT
PY 2010
VL 24
IS 5
BP 695
EP 708
DI 10.1016/j.bpg.2010.08.005
PG 14
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 688OB
UT WOS:000284859300016
PM 20955971
DA 2025-06-11
ER

PT J
AU Yeh, CW
   Yeh, SHH
   Shie, FS
   Lai, WS
   Liu, HK
   Tzeng, TT
   Tsay, HJ
   Shiao, YJ
AF Yeh, Chi-Wen
   Yeh, Skye Hsin-Hsien
   Shie, Feng-Shiun
   Lai, Wen-Sung
   Liu, Hui-Kang
   Tzeng, Tsai-Teng
   Tsay, Huey-Jen
   Shiao, Young-Ji
TI Impaired cognition and cerebral glucose regulation are associated with
   astrocyte activation in the parenchyma of metabolically stressed
   APPswe/PS1dE9 mice
SO NEUROBIOLOGY OF AGING
LA English
DT Article
DE Cognitive dysfunction; Cerebral glucose regulation; Astrocytes;
   Metabolic stresses; Amyloid plaque; Alzheimer's disease
ID TRANSGENIC MOUSE MODEL; BLOOD-BRAIN-BARRIER; ALZHEIMERS-DISEASE;
   INSULIN-RESISTANCE; NESTING-BEHAVIOR; ENERGY-METABOLISM; IN-VIVO;
   INFLAMMATION; DYSFUNCTION; AGE
AB Although metabolic syndrome was suggested to be a risk factor for Alzheimer's disease (AD), the role of metabolic stress in the initiation of AD pathology remains unclear. In this study, metabolic stress was induced by a high-fat diet and low-dose injection of streptozotocin (HFSTZ) before the appearance of senile plaques in APP/PS1 transgenic mice. We found that, HFSTZ treatment exacerbated amyloid beta burden and astrocyte activation in the vicinity of plaques. Moreover, we observed an upregulation of astrocytic S100B expression in the brain parenchyma of HFSTZ-treated APP/PS1 mice concurrent with increased interleukin-6 expression in cerebral microvascular cells. To determine the impact of HFSTZ treatment on brain function, we performed [F-18] fludeoxyglucose-positron emission tomography and analyzed nesting behavior. HFSTZ treatment impaired nest construction and cerebral glucose metabolism in several brain regions of APP/PS1 mice during the early stage of AD. These results suggest that HFSTZ-induced peripheral metabolic stress may contribute to vascular inflammation and astrocyte reactivity in the parenchyma and may impair activity of daily living skill and cerebral glucose metabolism in APP/PS1 mice. (C) 2015 Elsevier Inc. All rights reserved.
C1 [Yeh, Chi-Wen; Tsay, Huey-Jen] Natl Yang Ming Univ, Sch Life Sci, Brain Res Ctr, Inst Neurosci, Taipei 112, Taiwan.
   [Yeh, Skye Hsin-Hsien] Natl Yang Ming Univ, Brain Res Ctr, Taipei 112, Taiwan.
   [Yeh, Skye Hsin-Hsien] Natl Yang Ming Univ, Biophoton & Mol Imaging Res Ctr, Taipei 112, Taiwan.
   [Shie, Feng-Shiun] Natl Hlth Res Inst, Ctr Neuropsychiat Res, Zhunan Township, Miaoli County, Taiwan.
   [Lai, Wen-Sung] Natl Taiwan Univ, Dept Psychol, Grad Inst Brain & Mind Sci, Neurobiol & Cognit Sci Ctr, Taipei 10764, Taiwan.
   [Liu, Hui-Kang; Shiao, Young-Ji] Natl Res Inst Chinese Med, Div Basic Chinese Med, Taipei, Taiwan.
   [Liu, Hui-Kang; Shiao, Young-Ji] Taipei Med Univ, PhD Program Clin Drug Discovery Bot Herbs, Taipei, Taiwan.
   [Tzeng, Tsai-Teng; Shiao, Young-Ji] Natl Yang Ming Univ, Inst Biopharmaceut Sci, Taipei 112, Taiwan.
C3 National Yang Ming Chiao Tung University; National Yang Ming Chiao Tung
   University; National Yang Ming Chiao Tung University; National Health
   Research Institutes - Taiwan; National Taiwan University; National
   Research Institute of Chinese Medicine; Taipei Medical University;
   National Yang Ming Chiao Tung University
RP Tsay, HJ (corresponding author), Natl Yang Ming Univ, Sch Life Sci, Brain Res Ctr, Inst Neurosci, Taipei 112, Taiwan.
EM hjtsay@ym.edu.tw; yshiao@nricm.edu.tw
RI Shiao, Young-Ji/AAA-9647-2022; Shie, Feng-Shiun/E-3836-2010
OI Lai, Wen-Sung/0000-0001-6918-5531; Yeh, Chih-Wen/0000-0002-3833-2364
FU National Research Institute of Chinese Medicine [NRICM-101-PP02];
   Ministry of Science and Technology [MOST-102-2320-B-077-003,
   MOST-103-2320-B-077-004-MY3, MOST-103-2311-B-010-008]
FX The authors thank Chia-Lin Hsu for her technical support. This work was
   financially supported by the National Research Institute of Chinese
   Medicine (grant no. NRICM-101-PP02) and the Ministry of Science and
   Technology (grant no. MOST-102-2320-B-077-003;
   MOST-103-2320-B-077-004-MY3; and MOST-103-2311-B-010-008).
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NR 47
TC 32
Z9 32
U1 0
U2 19
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0197-4580
EI 1558-1497
J9 NEUROBIOL AGING
JI Neurobiol. Aging
PD NOV
PY 2015
VL 36
IS 11
BP 2984
EP 2994
DI 10.1016/j.neurobiolaging.2015.07.022
PG 11
WC Geriatrics & Gerontology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology; Neurosciences & Neurology
GA CU1LA
UT WOS:000363281700009
PM 26264859
DA 2025-06-11
ER

PT J
AU Xia, T
   Yu, JC
   Du, M
   Chen, XM
   Wang, CB
   Li, RB
AF Xia, Tian
   Yu, Jiachi
   Du, Meng
   Chen, Ximeng
   Wang, Chengbin
   Li, Ruibing
TI Vascular endothelial cell injury: causes, molecular mechanisms, and
   treatments
SO MEDCOMM
LA English
DT Review
DE cardiac I/R injury; diabetic vascular injury; endothelial cell; sepsis
ID NITRIC-OXIDE SYNTHASE; CARDIAC ISCHEMIA/REPERFUSION INJURY; PERCUTANEOUS
   CORONARY INTERVENTION; HEMODYNAMIC SHEAR-STRESS; FLOW-MEDIATED DILATION;
   DIABETES-MELLITUS ROLE; OXIDATIVE STRESS; PROGENITOR CELLS;
   CARDIOVASCULAR RISK; METABOLIC SYNDROME
AB Vascular endothelial cells form a single layer of flat cells that line the inner surface of blood vessels, extending from large vessels to the microvasculature of various organs. These cells are crucial metabolic and endocrine components of the body, playing vital roles in maintaining circulatory stability, regulating vascular tone, and preventing coagulation and thrombosis. Endothelial cell injury is regarded as a pivotal initiating factor in the pathogenesis of various diseases, triggered by multiple factors, including infection, inflammation, and hemodynamic changes, which significantly compromise vascular integrity and function. This review examines the causes, underlying molecular mechanisms, and potential therapeutic approaches for endothelial cell injury, focusing specifically on endothelial damage in cardiac ischemia/reperfusion (I/R) injury, sepsis, and diabetes. It delves into the intricate signaling pathways involved in endothelial cell injury, emphasizing the roles of oxidative stress, mitochondrial dysfunction, inflammatory mediators, and barrier damage. Current treatment strategies-ranging from pharmacological interventions to regenerative approaches and lifestyle modifications-face ongoing challenges and limitations. Overall, this review highlights the importance of understanding endothelial cell injury within the context of various diseases and the necessity for innovative therapeutic methods to improve patient outcomes.
C1 [Xia, Tian; Yu, Jiachi; Du, Meng; Chen, Ximeng; Wang, Chengbin; Li, Ruibing] First Med Ctr Chinese PLA Gen Hosp, Dept Lab Med, Beijing 100853, Peoples R China.
   [Xia, Tian; Yu, Jiachi; Chen, Ximeng; Wang, Chengbin; Li, Ruibing] Med Sch Chinese PLA, Dept Lab Med, Beijing, Peoples R China.
   [Du, Meng] Huaian Hosp Huaian City, Dept Clin Lab, Huaian, Jiangsu, Peoples R China.
RP Wang, CB; Li, RB (corresponding author), First Med Ctr Chinese PLA Gen Hosp, Dept Lab Med, Beijing 100853, Peoples R China.
EM wangcb301@126.com; liruibing@plagh.org
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NR 331
TC 1
Z9 1
U1 3
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
EI 2688-2663
J9 MEDCOMM
JI MedComm
PD FEB
PY 2025
VL 6
IS 2
AR e70057
DI 10.1002/mco2.70057
PG 30
WC Medicine, Research & Experimental
WE Emerging Sources Citation Index (ESCI)
SC Research & Experimental Medicine
GA S3T4B
UT WOS:001397485700001
PM 39931738
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Ohki, K
   Wakui, H
   Kishio, N
   Azushima, K
   Uneda, K
   Haku, S
   Kobayashi, R
   Haruhara, K
   Kinguchi, S
   Yamaji, T
   Yamada, T
   Minegishi, S
   Ishigami, T
   Toya, Y
   Yamashita, A
   Imajo, K
   Nakajima, A
   Kato, I
   Ohashi, K
   Tamura, K
AF Ohki, Kohji
   Wakui, Hiromichi
   Kishio, Nozomu
   Azushima, Kengo
   Uneda, Kazushi
   Haku, Sona
   Kobayashi, Ryu
   Haruhara, Kotaro
   Kinguchi, Sho
   Yamaji, Takahiro
   Yamada, Takayuki
   Minegishi, Shintaro
   Ishigami, Tomoaki
   Toya, Yoshiyuki
   Yamashita, Akio
   Imajo, Kento
   Nakajima, Atsushi
   Kato, Ikuma
   Ohashi, Kenichi
   Tamura, Kouichi
TI Angiotensin II Type 1 Receptor-associated Protein Inhibits Angiotensin
   II-induced Insulin Resistance with Suppression of Oxidative Stress in
   Skeletal Muscle Tissue
SO SCIENTIFIC REPORTS
LA English
DT Article
ID CARDIAC-HYPERTROPHY; ALDOSTERONE SYSTEM; ADIPOSE-TISSUE; GLUCOSE;
   ADIPONECTIN; SENSITIVITY; ACTIVATION; OBESITY; DIFFERENTIATION;
   INFLAMMATION
AB Enhancement of AT1 receptor-associated protein (ATRAP) in adipose tissue improves high fat diet (HFD)-induced visceral obesity and insulin resistance, and suppresses adipose oxidative stress. However, HFD loading is not a direct stimulatory factor for AT1 receptor. In the present study, we investigated the effect of chronic, low-dose angiotensin II (Ang II) stimulation on glucose and lipid metabolism in mice and functional role of ATRAP. ATRAP expression was higher in adipose tissue (5-10-fold) and skeletal muscle tissue (approximately 1.6-fold) in ATRAP transgenic (TG) mice compared with wild-type (WT) mice. After Ang II infusion, insulin sensitivity was impaired in WT mice, but this response was suppressed in TG mice. Unexpectedly, Ang II infusion did not affect the adipose tissue profile in WT or TG mice. However, in skeletal muscle tissue, Ang II stimulus caused an increase in oxidative stress and activation of p38 MAPK, resulting in a decrease in glucose transporter type 4 expression in WT mice. These responses were suppressed in TG mice. Our study suggests that Ang II-induced insulin resistance is suppressed by increased ATRAP expression in skeletal muscle tissue. Hyperactivity of AT1 receptor could be related to formation of insulin resistance related to metabolic syndrome.
C1 [Ohki, Kohji; Wakui, Hiromichi; Kishio, Nozomu; Azushima, Kengo; Uneda, Kazushi; Haku, Sona; Kobayashi, Ryu; Haruhara, Kotaro; Kinguchi, Sho; Yamaji, Takahiro; Yamada, Takayuki; Minegishi, Shintaro; Ishigami, Tomoaki; Toya, Yoshiyuki; Tamura, Kouichi] Yokohama City Univ, Dept Med Sci & Cardiorenal Med, Grad Sch Med, Yokohama, Kanagawa, Japan.
   [Azushima, Kengo] Duke NUS Med Sch, Cardiovasc & Metab Disorders Program, Singapore, Singapore.
   [Yamashita, Akio] Yokohama City Univ, Dept Mol Biol, Grad Sch Med, Yokohama, Kanagawa, Japan.
   [Imajo, Kento; Nakajima, Atsushi] Yokohama City Univ, Dept Gastroenterol & Hepatol, Grad Sch Med, Yokohama, Kanagawa, Japan.
   [Kato, Ikuma; Ohashi, Kenichi] Yokohama City Univ, Dept Mol Pathol, Grad Sch Med, Yokohama, Kanagawa, Japan.
C3 Yokohama City University; National University of Singapore; Yokohama
   City University; Yokohama City University; Yokohama City University
RP Wakui, H; Azushima, K; Tamura, K (corresponding author), Yokohama City Univ, Dept Med Sci & Cardiorenal Med, Grad Sch Med, Yokohama, Kanagawa, Japan.; Azushima, K (corresponding author), Duke NUS Med Sch, Cardiovasc & Metab Disorders Program, Singapore, Singapore.
EM hiro1234@yokohama-cu.ac.jp; azushima@yokohama-cu.ac.jp;
   tamukou@med.yokohama-cu.ac.jp
RI Uneda, Kazushi/LSM-1315-2024; Haruhara, Kotaro/AAE-6846-2020; Kobayashi,
   Ryu/NBY-1474-2025; Imajo, Kento/AAF-5744-2020; Kato, Ikuma/IUQ-1535-2023
OI Kato, Ikuma/0000-0002-7731-9509; Azushima, Kengo/0000-0002-5136-0730;
   Uneda, Kazushi/0000-0002-9660-142X; Haruhara, Kotaro/0000-0003-1918-0390
FU Yokohama Foundation for Advancement of Medical Science; Uehara Memorial
   Foundation grant; Japan Society for the Promotion of Science; SENSHIN
   Medical Research; Banyu Life Science Foundation International; Salt
   Science Research Foundation [1733]; Cardiovascular Research Fund, Tokyo,
   Japan; Japan Agency for Medical Research and Development (AMED);
   Translational Research program; Strategic PRomotion for practical
   application of INnovative medical Technology (TR-SPRINT) from AMED;
   Grants-in-Aid for Scientific Research [17H06993, 16K19558, 15H04331,
   17H05671, 17K09313, 17K19665] Funding Source: KAKEN
FX We acknowledge the help of Dr. Philipp E. Scherer (The University of
   Texas Southwestern Medical Center), who provided us with the 5.4-kb
   fragment of the adiponectin promoter. We thank Takayuki Akagi for
   technical assistance. This work was supported by grants from the
   Yokohama Foundation for Advancement of Medical Science, a Uehara
   Memorial Foundation grant, Grants-in-Aid for Scientific Research from
   the Japan Society for the Promotion of Science, grants from SENSHIN
   Medical Research, the Banyu Life Science Foundation International, and
   the Salt Science Research Foundation (1733), and a grant-in-aid from The
   Cardiovascular Research Fund, Tokyo, Japan. This research is also
   partially supported by Japan Agency for Medical Research and Development
   (AMED) and by The Translational Research program; Strategic PRomotion
   for practical application of INnovative medical Technology (TR-SPRINT)
   from AMED.
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NR 48
TC 18
Z9 21
U1 0
U2 2
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD FEB 12
PY 2018
VL 8
AR 2846
DI 10.1038/s41598-018-21270-8
PG 12
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA FV7DP
UT WOS:000424743500062
PM 29434287
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Rocha, JÉL
   Furtado, MM
   Neto, RSM
   Mendes, AVD
   Brito, AKD
   de Almeida, JOCS
   Queiroz, EIR
   Franca, JVD
   Primo, MGS
   Sales, ALDC
   Vasconcelos, AG
   Cabral, WF
   Kückelhaus, SAS
   Leite, JRDD
   Lustosa, AKMF
   Lucarini, M
   Durazzo, A
   Arcanjo, DDR
   Martins, MDDE
AF Lima Rocha, Joana Erica
   Mendes Furtado, Mariely
   Mello Neto, Renato Sampaio
   da Silva Mendes, Ana Victoria
   Brito, Ana Karolinne da Silva
   Sena de Almeida, Jose Otavio Carvalho
   Rodrigues Queiroz, Emerson Iuri
   Sousa Franca, Jose Vinicius de
   Silva Primo, Maisa Guimaraes
   Cunha Sales, Ana Lina de Carvalho
   Gomes Vasconcelos, Andreanne
   Felix Cabral, Wanessa
   Souza Kuckelhaus, Selma Aparecida
   de Souza de Almeida Leite, Jose Roberto
   Fortes Lustosa, Ana Karina Marques
   Lucarini, Massimo
   Durazzo, Alessandra
   Arcanjo, Daniel Dias Rufino
   Martins, Maria do Carmo de Carvalho e
TI Effects of Fish Oil Supplementation on Oxidative Stress Biomarkers and
   Liver Damage in Hypercholesterolemic Rats
SO NUTRIENTS
LA English
DT Article
DE dyslipidemias; oxidative stress; antioxidants; fish oil; dietary
   supplements
ID POLYUNSATURATED FATTY-ACIDS; CARDIOVASCULAR-DISEASE; RISK-FACTORS;
   HEALTH-CARE; PREVENTION; GUIDELINES; OMEGA-3; UPDATE; ASSAY
AB Metabolic syndrome, especially its component related to dyslipidemia, is related to the development of nonalcoholic fatty liver disease (NAFLD), which is a disease with a significant global prevalence. Supplementation with omega-3 polyunsaturated fatty acids emerged as a complementary therapeutic possibility for dyslipidemia, but its benefits are questioned. This paper aims at evaluating the effects of fish oil supplementation in rats with hypercholesterolemia induced by hypercholesterolemic diet (HD). The study design is based on an experimental model in which the animals were randomly divided into 3 groups: G1 (standard commercial feed + saline solution); G2 (hypercholesterolemic diet + saline solution) and G3 (hypercholesterolemic diet + fish oil) over a period of 16 weeks. Metabolic control parameters and oxidative stress biomarkers were evaluated according to standardized methodologies. The G3 group showed significantly lower values of plasma concentrations of TG, and hepatic myeloperoxidase as well as higher erythrocyte superoxide dismutase activity (p < 0.05). Regarding histopathological analysis, there was lipid accumulation in the liver of animals from group G2; meanwhile, hepatocytes reorganization and expressive reduction of lipid vacuoles and hepatic TG content was observed in group G3. This study demonstrated how fish oil supplementation reduced the plasma concentration and hepatic content of triglycerides, as well as liver tissue damage in histopathological analysis.
C1 [Lima Rocha, Joana Erica; Mendes Furtado, Mariely; Mello Neto, Renato Sampaio; da Silva Mendes, Ana Victoria; Brito, Ana Karolinne da Silva; Sena de Almeida, Jose Otavio Carvalho; Rodrigues Queiroz, Emerson Iuri; Sousa Franca, Jose Vinicius de; Silva Primo, Maisa Guimaraes; Cunha Sales, Ana Lina de Carvalho; Arcanjo, Daniel Dias Rufino; Martins, Maria do Carmo de Carvalho e] Univ Fed Piaui, Dept Biophys & Physiol, BR-64049550 Teresina, Brazil.
   [Gomes Vasconcelos, Andreanne; Felix Cabral, Wanessa; Souza Kuckelhaus, Selma Aparecida; de Souza de Almeida Leite, Jose Roberto] Univ Brasilia, Fac Med, Res Ctr Morphol & Appl Immunol, BR-70910900 Brasilia, Brazil.
   [Fortes Lustosa, Ana Karina Marques] Galeno Farm Manipulacao, Virginia Regina Fortes Castelo Branco & Cia Ltda, BR-64001260 Teresina, Brazil.
   [Lucarini, Massimo; Durazzo, Alessandra] CREA Res Ctr Food & Nutr, Via Ardeatina 546, I-00178 Rome, Italy.
C3 Universidade Federal do Piaui; Universidade de Brasilia; Consiglio per
   la Ricerca in Agricoltura e L'analisi Dell'economia Agraria (CREA)
RP Martins, MDDE (corresponding author), Univ Fed Piaui, Dept Biophys & Physiol, BR-64049550 Teresina, Brazil.
EM ericarocha6@hotmail.com; marielymf@live.com;
   renato.sampaio.mn@gmail.com; victoriams18@hotmail.com;
   anakarolinnesb@hotmail.com; otavios.almeida@hotmail.com;
   emersoniuri@ufpi.edu.br; vinicius.sfranca@ufpi.edu.br;
   maisaguimaraessp@gmail.com; ana.lina123@gmail.com;
   andreannegv@gmail.com; wanessa.felix@unb.br; selmask@gmail.com;
   jrsaleite@gmail.com; ana_lustosa@uol.com.br;
   massimo.lucarini@crea.gov.it; alessandra.durazzo@crea.gov.it;
   daniel.arcanjo@ufpi.edu.br; carminhamartins@ufpi.edu.br
RI Brito, Ana/LKK-0208-2024; Lucarini, Massimo/AAL-9254-2020; Durazzo,
   Alessandra/AAN-4182-2020; Martins, MARIA DO CARMO DE CARVALHO
   E/AAK-9854-2020; Leite, José/H-9065-2013; Arcanjo, Daniel/D-8851-2012
OI Kuckelhaus, Selma/0000-0001-7677-772X; de Sousa Franca, Jose
   Vinicius/0000-0001-5716-811X; Arcanjo, Daniel/0000-0001-7021-2744; Gomes
   Vasconcelos, Andreanne/0000-0002-9651-1598; da Silva Brito, Ana
   Karolinne/0000-0002-9575-2103; Mello Neto, Renato
   Sampaio/0000-0001-7301-3417
FU Fundacao de Amparo a Pesquisa do Estado do Piaui, Brazil [Edital
   FAPEPI/MSDECIT/CNPq/SESAPI No002/2016-PPSUS, EFP_00012110]
FX This research received funding from Fundacao de Amparo a Pesquisa do
   Estado do Piaui, Brazil (Edital FAPEPI/MSDECIT/CNPq/SESAPI
   No002/2016-PPSUS; Number EFP_00012110).
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NR 45
TC 18
Z9 18
U1 0
U2 13
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD FEB
PY 2022
VL 14
IS 3
AR 426
DI 10.3390/nu14030426
PG 15
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA ZF0VK
UT WOS:000759293400001
PM 35276784
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Kozlowska, A
   Dzierzanowski, T
AF Kozlowska, Aleksandra
   Dzierzanowski, Tomasz
TI Targeting Inflammation by Anthocyanins as the Novel Therapeutic
   Potential for Chronic Diseases: An Update
SO MOLECULES
LA English
DT Review
DE anthocyanins; inflammation; oxidative stress
ID LOW-GRADE INFLAMMATION; MAJOR FOOD SOURCES; CARDIOVASCULAR-DISEASE;
   METABOLIC SYNDROME; FLAVONOID INTAKE; HEALTH-BENEFITS; OLDER-ADULTS;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; DIET
AB Low-grade chronic inflammation (LGCI) and oxidative stress act as cooperative and synergistic partners in the pathogenesis of a wide variety of diseases. Polyphenols, including anthocyanins, are involved in regulating the inflammatory state and activating the endogenous antioxidant defenses. Anthocyanins' effects on inflammatory markers are promising and may have the potential to exert an anti-inflammatory effect in vitro and in vivo. Therefore, translating these research findings into clinical practice would effectively contribute to the prevention and treatment of chronic disease. The present narrative review summarizes the results of clinical studies from the last 5 years in the context of the anti-inflammatory and anti-oxidative role of anthocyanins in both health and disease. There is evidence to indicate that anthocyanins supplementation in the regulation of pro-inflammatory markers among the healthy and chronic disease population. Although the inconsistencies between the result of randomized control trials (RCTs) and meta-analyses were also observed. Regarding anthocyanins' effects on inflammatory markers, there is a need for long-term clinical trials allowing for the quantifiable progression of inflammation. The present review can help clinicians and other health care professionals understand the importance of anthocyanins use in patients with chronic diseases.
C1 [Kozlowska, Aleksandra; Dzierzanowski, Tomasz] Med Univ Warsaw, Dept Social Med & Publ Hlth, PL-02776 Warsaw, Poland.
C3 Medical University of Warsaw
RP Dzierzanowski, T (corresponding author), Med Univ Warsaw, Dept Social Med & Publ Hlth, PL-02776 Warsaw, Poland.
EM akozlowska2@wum.edu.pl; tomasz.dzierzanowski@wum.edu.pl
RI Dzierzanowski, Tomasz/L-6409-2016; Kozlowska, Aleksandra/B-7980-2019
OI Dzierzanowski, Tomasz/0000-0001-5719-5695; Kozlowska,
   Aleksandra/0000-0002-6596-7269
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NR 124
TC 38
Z9 40
U1 5
U2 33
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1420-3049
J9 MOLECULES
JI Molecules
PD JUL
PY 2021
VL 26
IS 14
AR 4380
DI 10.3390/molecules26144380
PG 17
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA TN6MK
UT WOS:000676346400001
PM 34299655
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Srivastava, R
   Faust, T
   Ramos, A
   Ishizuka, K
   Sawa, A
AF Srivastava, Rupali
   Faust, Travis
   Ramos, Adriana
   Ishizuka, Koko
   Sawa, Akira
TI Dynamic Changes of the Mitochondria in Psychiatric Illnesses: New
   Mechanistic Insights From Human Neuronal Models
SO BIOLOGICAL PSYCHIATRY
LA English
DT Review
DE Bipolar disorder; Calcium dysregulation; Human neuronal cell models;
   Mitochondria; Oxidative stress; Schizophrenia
ID PLURIPOTENT STEM-CELLS; ENDOPLASMIC-RETICULUM STRESS; CALCIUM-ION
   CONCENTRATION; OXIDATIVE STRESS; BIPOLAR DISORDER; NEUROPSYCHIATRIC
   DISORDERS; NEURODEGENERATIVE DISEASES; FUNCTIONAL-NEURONS; METABOLIC
   SYNDROME; PREFRONTAL CORTEX
AB Mitochondria play a crucial role in neuronal function, especially in energy production, the generation of reactive oxygen species, and calcium signaling. Multiple lines of evidence have suggested the possible involvement of mitochondrial deficits in major psychiatric disorders, such as schizophrenia and bipolar disorder. This review will outline the current understanding of the physiological role of mitochondria and their dysfunction under pathological conditions, particularly in psychiatric disorders. The current knowledge about mitochondrial deficits in these disorders is somewhat limited because of the lack of effective methods to dissect dynamic changes in functional deficits that are directly associated with psychiatric conditions. Human neuronal cell model systems have been dramatically developed in recent years with the use of stem cell technology, and these systems may be key tools for overcoming this dilemma and improving our understanding of the dynamic changes in the mitochondrial deficits in patients with psychiatric disorders. We introduce recent discoveries from new experimental models and conclude the discussion by referring to future perspectives. We emphasize the significance of combining studies of human neuronal cell models with those of other experimental systems, including animal models.
C1 [Srivastava, Rupali; Faust, Travis; Ramos, Adriana; Ishizuka, Koko; Sawa, Akira] Johns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, Baltimore, MD USA.
C3 Johns Hopkins University
RP Sawa, A (corresponding author), Johns Hopkins Sch Med Psychiat & Neurosci, 600 North Wolfe St,Meyer 3-166, Baltimore, MD 21287 USA.
EM asawa1@jhmi.edu
OI Faust, Travis/0000-0002-4567-8435
FU National Institute of Mental Health [R01MH092443]; Stanley and S-R/RUSK;
   National Alliance for Research on Schizophrenia and Depression; Maryland
   Stem Cell Research Fund; International Bipolar Foundation through a
   Brain and Behavior Research Foundation Young Investigator Grant [25465];
   National Institute of Mental Health from the Silvio O. Conte Center
   [R01MH105660, P50MH094268]
FX This work was supported by National Institute of Mental Health Grant
   Nos. R01MH105660 (to AS and KI) and P50MH094268 from the Silvio O. Conte
   Center and R01MH092443 (to AS); foundation grants from Stanley and
   S-R/RUSK (to AS), National Alliance for Research on Schizophrenia and
   Depression (to AS, KI, and RS), and the Maryland Stem Cell Research Fund
   (to AS and KI); and the International Bipolar Foundation through a Brain
   and Behavior Research Foundation Young Investigator Grant No. 25465 (to
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NR 103
TC 40
Z9 42
U1 3
U2 17
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0006-3223
EI 1873-2402
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD MAY 1
PY 2018
VL 83
IS 9
BP 751
EP 760
DI 10.1016/j.biopsych.2018.01.007
PG 10
WC Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA GB9YQ
UT WOS:000429431400007
PM 29486891
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Yorke, E
   Boima, V
   Dey, ID
   Ganu, V
   Nkornu, N
   Acquaye, KS
   Mate-Kole, CC
AF Yorke, Ernest
   Boima, Vincent
   Dey, Ida Dzifa
   Ganu, Vincent
   Nkornu, Norah
   Acquaye, Kelvin Samuel
   Mate-Kole, C. Charles
TI Comparison of neurocognitive changes among newly diagnosed tuberculosis
   patients with and without dysglycaemia
SO BMC PSYCHIATRY
LA English
DT Article
DE Tuberculosis; Smear positive; Dysglycaemia; Neuropsychological disorders
ID DIABETES-MELLITUS; COGNITIVE DYSFUNCTION; METABOLIC SYNDROME;
   OLDER-ADULTS; RISK; ANXIETY; METAANALYSIS; PREVALENCE; DEMENTIA; INSULIN
AB Background Diabetes often occurs together with tuberculosis (TB) and both may affect each other negatively. Diabetes may be associated with neurocognitive dysfunctioning in affected patients and may negatively impact treatment adherence and outcomes. This study compared the neurocognitive status between newly diagnosed smear positive tuberculosis patients with dysglycaemia and those with normoglycaemia. Methods The current study was a cross-sectional study involving one hundred and forty-six (146) newly diagnosed smear positive TB patients. Oral glucose tolerance test (OGTT) was performed and the results were categorized as either normoglycaemia, impaired glucose tolerance (IGT), impaired fasting glucose (IFG) or diabetes. Neurocognitive functioning among study participants was assessed at the time of TB diagnosis using Cognitive Failure Questionnaire (CFQ), Montreal Cognitive Assessment tool (MoCA), California Verbal Learning Test (CVLT), Brief Symptom Inventory (BSI) and the Spitzer Quality of Life Index (QLI). Results The mean age of the participants (n = 146) was 38.7 years with 78.8% being males and 21.2% females. Using the fasting blood glucose test, the prevalence of impaired fasting glucose and diabetes were 5.5 and 3.4% respectively, both representing a total of 13 out of the 146 participants; whilst the prevalence of impaired glucose tolerance and diabetes using 2-h post-glucose values were 28.8 and 11.6% respectively, both representing a total of 59 out of the 146 participants. There were no significant differences in the mean scores on the neurocognitive measures between the dysglaycaemia and normoglycamic groups using fasting plasma glucose (FPG). However, there were significant differences in the mean scores between the dysglycaemia and normal groups using 2-h postprandial (2HPP) glucose values on Phobic Anxiety (Normal, Mean = 0.38 +/- 0.603; dysglycaemia, Mean = 0.23 +/- 0.356; p = 0.045), and Montreal Cognitive Assessment (MoCA) scores (17.26 +/- 5.981 vs. 15.04 +/- 5.834, p = 0.037). Conclusion Newly diagnosed smear positive patients with dysglycaemia were associated with significantly lower mean cognitive scores and scores on phobic anxiety than those with normoglyacaemia. The latter finding must be further explored.
C1 [Yorke, Ernest; Boima, Vincent; Dey, Ida Dzifa] Univ Ghana, Coll Hlth Sci, Sch Med & Dent, Dept Med & Therapeut, Legon, Accra, Ghana.
   [Ganu, Vincent] Korle Bu Teaching Hosp, Dept Med, Accra, Ghana.
   [Nkornu, Norah; Mate-Kole, C. Charles] Univ Ghana, Coll Humanities, Sch Social Sci, Dept Psychol, Accra, Ghana.
   [Acquaye, Kelvin Samuel] Univ Ghana, Sch Publ Hlth, Dept Social & Behav Sci, Accra, Ghana.
   [Mate-Kole, C. Charles] Coll Hlth Sci, Sch Med & Dent, Dept Psychiat, Korle Bu, Accra, Ghana.
   [Mate-Kole, C. Charles] Univ Ghana, Coll Humanities, Ctr Ageing Studies, Accra, Ghana.
C3 University of Ghana; University of Ghana; University of Ghana;
   University of Ghana
RP Yorke, E (corresponding author), Univ Ghana, Coll Hlth Sci, Sch Med & Dent, Dept Med & Therapeut, Legon, Accra, Ghana.
EM pavlovium@yahoo.com
RI Yorke, Ernest/LSK-2684-2024
OI Yorke, Ernest/0000-0003-4257-7492; Boima, Vincent/0000-0002-0562-6307;
   Ganu, Vincent/0000-0001-8649-4344; Dey, Ida Dzifa/0000-0002-3339-5112
FU University of Ghana Office of Research, Innovation and Development
   (ORID) grant [URF/9/ILG-076/2015-2016]
FX This study was mostly funded by a University of Ghana Office of
   Research, Innovation and Development (ORID) grant (Project Reference
   Number: URF/9/ILG-076/2015-2016). The funds supported the design of the
   study and collection, analysis, and interpretation of data.
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NR 47
TC 0
Z9 0
U1 0
U2 4
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-244X
J9 BMC PSYCHIATRY
JI BMC Psychiatry
PD APR 3
PY 2020
VL 20
IS 1
AR 143
DI 10.1186/s12888-020-02570-8
PG 7
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA LA0BS
UT WOS:000523623100005
PM 32245444
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Gholami, M
   Zarei, P
   Sedeh, BS
   Rafiei, F
   Khosrowbeygi, A
AF Gholami, Mahsa
   Zarei, Parvin
   Sedeh, Bahman Sadeghi
   Rafiei, Fatemeh
   Khosrowbeygi, Ali
TI Effects of coenzyme Q10 supplementation on serum values of adiponectin,
   leptin, 8-isoprostane and malondialdehyde in women with type 2 diabetes
SO GYNECOLOGICAL ENDOCRINOLOGY
LA English
DT Article
DE Type 2 diabetes; coenzyme Q10; adiponectin; leptin; oxidative stress
ID PLASMA ADIPONECTIN; OXIDATIVE STRESS; METABOLIC SYNDROME; INFLAMMATION;
   METAANALYSIS; BIOMARKERS; PARAMETERS; MARKERS; DISEASE; ALPHA
AB Patients with type 2 diabetes mellitus (T2DM) have been known to be suffering from coenzyme Q10 (CoQ10) deficiency which results in some complications in them. The purpose of this clinical trial study was to evaluate the effects of CoQ10 supplementation on serum values of adiponectin (A), leptin (L), 8-isoprostane, malondialdehyde (MDA), the A/L ratio in women with T2DM. Sixty-eight women with T2DM were enrolled in the current study and were randomly divided into drug (n = 34) and placebo (n = 34) groups who were consuming 100 mg CoQ10 and 100 mg cellulose acetate per day for 12 weeks, respectively. Measurements were performed at the beginning and after the intervention. Serum values of adiponectin (p = .001) and the A/L ratio (p = .001) were increased while values of leptin (p = .041), MDA (p = .023), 8-isoprostane (p = .004) were decreased significantly in drug group after intervention. This study had shown that CoQ10 supplementation in women with T2DM was effective in elevation of adiponectin and the A/L ratio and reduction of leptin, MDA and 8-isoprostane which could result in improving insulin resistance and modulating oxidative stress situation.
C1 [Gholami, Mahsa; Zarei, Parvin] Arak Univ Med Sci, Iran Student Res Comm, Arak, Iran.
   [Sedeh, Bahman Sadeghi] Arak Univ Med Sci, Sch Med, Dept Social Med, Endocrinol & Metab Res Ctr, Arak, Iran.
   [Rafiei, Fatemeh] Arak Univ Med Sci, Sch Med, Dept Biostat, Endocrinol & Metab Res Ctr, Arak, Iran.
   [Khosrowbeygi, Ali] Arak Univ Med Sci, Sch Med, Dept Biochem & Genet, Endocrinol & Metab Res Ctr, Arak, Iran.
RP Khosrowbeygi, A (corresponding author), Arak Univ Med Sci, Sch Med, Dept Biochem & Genet, Endocrinol & Metab Res Ctr, Arak, Iran.
EM khosrowbeygi@yahoo.com
RI sadeghi sedeh, bahman/AAT-9409-2021; Rafiei, Fatemeh/AFK-0185-2022;
   sadeghi, bahman/F-9281-2016
OI sadeghi, bahman/0000-0002-1667-6879
FU Research Council of Arak University of Medical Sciences [2622B/2594]
FX This study was supported by the Research Council of Arak University of
   Medical Sciences for the financial support (Grant Number: 2622B/2594).
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NR 29
TC 19
Z9 19
U1 0
U2 3
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0951-3590
EI 1473-0766
J9 GYNECOL ENDOCRINOL
JI Gynecol. Endocrinol.
PD DEC 2
PY 2018
VL 34
IS 12
BP 1059
EP 1063
DI 10.1080/09513590.2018.1481944
PG 5
WC Endocrinology & Metabolism; Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Obstetrics & Gynecology
GA HE1JC
UT WOS:000453025700013
PM 29933718
DA 2025-06-11
ER

PT J
AU Blat, S
   Vincent, S
   Lefeuvre, L
   Lemoine-Morel, S
   Malbert, CH
   Pichon, L
   Mikogami, T
   Gratas-Delamarche, A
AF Blat, Sophie
   Vincent, Sophie
   Lefeuvre, Luz
   Lemoine-Morel, Sophie
   Malbert, Charles-Henri
   Pichon, Lisa
   Mikogami, Takashi
   Gratas-Delamarche, Arlette
TI Dietary α-Lactalbumin Supplementation Alleviates Normocaloric Western
   Diet-Induced Glucose Intolerance in Gottingen Minipigs
SO OBESITY
LA English
DT Article
ID INDUCED OXIDATIVE STRESS; OBESE NONDIABETIC SUBJECTS; WHEY-PROTEIN;
   INSULIN-RESISTANCE; BODY-WEIGHT; HIGH-FAT; POSTPRANDIAL LIPEMIA;
   METABOLIC SYNDROME; LIPID-METABOLISM; HEALTHY-SUBJECTS
AB ObjectiveThe pandemic of obesity in Western countries is mainly due to the high-fat, high-energy diet prevailing there. Obesity-associated metabolic disorders are the consequence of fat mass increase leading to altered adipokine secretion, hyperlipemia, oxidant stress, low-grade inflammation, and eventually glucose intolerance. Yet not all people consuming a Western diet become obese, and the question is raised whether these people are also at risk of developing metabolic disorders.
   MethodsGlucose tolerance, lipid profile, and oxidant and inflammation status were investigated longitudinally in lean Gottingen minipigs receiving for 16 weeks either a normal diet (ND), a Western diet (WD), or a Western diet supplemented with a whey protein isolate (WPI) rich in -lactalbumin known to improve glucose tolerance. ND and WD were supplied isoenergetically.
   ResultsLean minipigs fed WD displayed glucose intolerance and altered lipid profile after 6 weeks of diet but no inflammation or oxidative stress. Supplementation with WPI alleviated glucose intolerance by improving insulin secretion, but not lipid profile.
   ConclusionsWestern diet consumption is deleterious for glucose tolerance even in the absence of fat mass accretion, and dyslipemia is a major determinant for this metabolic dysfunction. Stimulating insulin secretion with a WPI is an effective strategy to improve glucose tolerance.
C1 [Blat, Sophie; Malbert, Charles-Henri] INRA, UR1341, ADNC, F-35590 St Gilles, France.
   [Vincent, Sophie; Lefeuvre, Luz; Lemoine-Morel, Sophie; Gratas-Delamarche, Arlette] UEB ENS Rennes M2S, F-35170 Bruz, France.
   [Pichon, Lisa; Mikogami, Takashi] Armor Prot, F-35460 St Brice En Cogles, France.
C3 INRAE; Ecole Normale Superieure de Rennes (ENS Rennes)
RP Blat, S (corresponding author), INRA, UR1341, ADNC, F-35590 St Gilles, France.
EM sophie.blat@rennes.inra.fr
OI Mikogami, Takashi/0000-0003-0412-7626
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NR 40
TC 4
Z9 4
U1 0
U2 22
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1930-7381
EI 1930-739X
J9 OBESITY
JI Obesity
PD FEB
PY 2015
VL 23
IS 2
BP 415
EP 421
DI 10.1002/oby.20990
PG 7
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA CA6QN
UT WOS:000349040400025
PM 25594308
OA Bronze
DA 2025-06-11
ER

PT J
AU Correll, CU
   Detraux, J
   De Lepeleire, J
   De Hert, M
AF Correll, Christoph U.
   Detraux, Johan
   De Lepeleire, Jan
   De Hert, Marc
TI Effects of antipsychotics, antidepressants and mood stabilizers on risk
   for physical diseases in people with schizophrenia, depression and
   bipolar disorder
SO WORLD PSYCHIATRY
LA English
DT Article
DE Physical illness; cardiovascular; metabolic; endocrine;
   gastrointestinal; respiratory; schizophrenia; bipolar disorder;
   depression; antipsychotics; antidepressants; mood stabilizers
ID SEROTONIN REUPTAKE INHIBITORS; BONE-MINERAL DENSITY; ACUTE
   MYOCARDIAL-INFARCTION; SEVERE MENTAL-ILLNESS; TORSADE-DE-POINTES;
   2ND-GENERATION ANTIPSYCHOTICS; DIABETES-MELLITUS; METABOLIC SYNDROME;
   ATYPICAL ANTIPSYCHOTICS; FRACTURE RISK
AB People with severe mental illness have a considerably shorter lifespan than the general population. This excess mortality is mainly due to physical illness. Next to mental illness-related factors, unhealthy lifestyle, and disparities in health care access and utilization, psychotropic medications can contribute to the risk of physical morbidity and mortality. We systematically reviewed the effects of antipsychotics, antidepressants and mood stabilizers on physical health outcomes in people with schizophrenia, depression and bipolar disorder. Updating and expanding our prior systematic review published in this journal, we searched MEDLINE (November 2009 - November 2014), combining the MeSH terms of major physical disease categories (and/or relevant diseases within these categories) with schizophrenia, major depressive disorder and bipolar disorder, and the three major psychotropic classes which received regulatory approval for these disorders, i.e., antipsychotics, antidepressants and mood stabilizers. We gave precedence to results from (systematic) reviews and meta-analyses wherever possible. Antipsychotics, and to a more restricted degree antidepressants and mood stabilizers, are associated with an increased risk for several physical diseases, including obesity, dyslipidemia, diabetes mellitus, thyroid disorders, hyponatremia; cardiovascular, respiratory tract, gastrointestinal, haematological, musculoskeletal and renal diseases, as well as movement and seizure disorders. Higher dosages, polypharmacy, and treatment of vulnerable (e.g., old or young) individuals are associated with greater absolute (elderly) and relative (youth) risk for most of these physical diseases. To what degree medication-specific and patient-specific risk factors interact, and how adverse outcomes can be minimized, allowing patients to derive maximum benefits from these medications, requires adequate clinical attention and further research.
C1 [Correll, Christoph U.] North Shore Long Isl Jewish Hlth Syst, Zucker Hillside Hosp, Dept Psychiat, New York, NY 10075 USA.
   [Correll, Christoph U.] Hofstra North Shore LIJ Sch Med, Dept Psychiat & Mol Med, Hempstead, NY USA.
   [Correll, Christoph U.] Feinstein Inst Med Res, Psychiat Neurosci Ctr Excellence, Manhasset, NY USA.
   [Correll, Christoph U.] Albert Einstein Coll Med, Dept Psychiat & Behav Sci, Bronx, NY 10467 USA.
   [Detraux, Johan; De Hert, Marc] Katholieke Univ Leuven, Dept Neurosci, B-3070 Kortenberg, Belgium.
   [De Lepeleire, Jan] Univ Leuven, Dept Publ Hlth & Primary Care, B-3000 Leuven, Belgium.
C3 Northwell Health; Hofstra University; Northwell Health; Northwell
   Health; Yeshiva University; Montefiore Medical Center; Albert Einstein
   College of Medicine; KU Leuven; KU Leuven
RP Correll, CU (corresponding author), North Shore Long Isl Jewish Hlth Syst, Zucker Hillside Hosp, Dept Psychiat, New York, NY 10075 USA.
RI Correll, Christoph/D-3530-2011; De Hert, Marc/AAH-6090-2021; Detraux,
   Johan/B-4487-2019
OI De Hert, Marc/0000-0003-4255-5920; Detraux, Johan/0000-0002-6363-3767
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NR 282
TC 600
Z9 633
U1 6
U2 162
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1723-8617
EI 2051-5545
J9 WORLD PSYCHIATRY
JI World Psychiatry
PD JUN
PY 2015
VL 14
IS 2
BP 119
EP 136
DI 10.1002/wps.20204
PG 18
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA CK2BZ
UT WOS:000356015600003
PM 26043321
OA Green Accepted, Green Published, Bronze
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Yamaguchi, T
   Yoshida, K
   Murata, M
   Suwa, K
   Tsuneyama, K
   Matsuzaki, K
   Naganuma, M
AF Yamaguchi, Takashi
   Yoshida, Katsunori
   Murata, Miki
   Suwa, Kanehiko
   Tsuneyama, Koichi
   Matsuzaki, Koichi
   Naganuma, Makoto
TI Smad3 Phospho-Isoform Signaling in Nonalcoholic Steatohepatitis
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE nonalcoholic steatohepatitis; Smad; transforming growth factor-beta;
   hepatocellular carcinoma
ID FATTY LIVER-DISEASE; NF-KAPPA-B; OXIDATIVE DNA-DAMAGE;
   HEPATOCELLULAR-CARCINOMA; METABOLIC SYNDROME; TUMOR SUPPRESSION;
   UNITED-STATES; KUPFFER CELLS; CANCER-RISK; INFLAMMATION
AB Nonalcoholic fatty liver disease (NAFLD) is characterized by hepatic steatosis with insulin resistance, oxidative stress, lipotoxicity, adipokine secretion by fat cells, endotoxins (lipopolysaccharides) released by gut microbiota, and endoplasmic reticulum stress. Together, these factors promote NAFLD progression from steatosis to nonalcoholic steatohepatitis (NASH), fibrosis, and eventually end-stage liver diseases in a proportion of cases. Hepatic fibrosis and carcinogenesis often progress together, sharing inflammatory pathways. However, NASH can lead to hepatocarcinogenesis with minimal inflammation or fibrosis. In such instances, insulin resistance, oxidative stress, and lipotoxicity can directly lead to liver carcinogenesis through genetic and epigenetic alterations. Transforming growth factor (TGF)-beta signaling is implicated in hepatic fibrogenesis and carcinogenesis. TGF-beta type I receptor (T beta RI) and activated-Ras/c-Jun-N-terminal kinase (JNK) differentially phosphorylate the mediator Smad3 to create two phospho-isoforms: C-terminally phosphorylated Smad3 (pSmad3C) and linker-phosphorylated Smad3 (pSmad3L). T beta RI/pSmad3C signaling terminates cell proliferation, while constitutive Ras activation and JNK-mediated pSmad3L promote hepatocyte proliferation and carcinogenesis. The pSmad3L signaling pathway also antagonizes cytostatic pSmad3C signaling. This review addresses TGF-beta/Smad signaling in hepatic carcinogenesis complicating NASH. We also discuss Smad phospho-isoforms as biomarkers predicting HCC in NASH patients with or without cirrhosis.
C1 [Yamaguchi, Takashi; Yoshida, Katsunori; Murata, Miki; Suwa, Kanehiko; Matsuzaki, Koichi; Naganuma, Makoto] Kansai Med Univ, Dept Gastroenterol & Hepatol, 2-5-1 Shin Machi, Hirakata, Osaka 5731010, Japan.
   [Tsuneyama, Koichi] Tokushima Univ, Inst Biomed Sci, Dept Pathol & Lab Med, Grad Sch, 3-18-15 Kuramoto, Tokushima 7708503, Japan.
C3 Kansai Medical University; Tokushima University
RP Yamaguchi, T (corresponding author), Kansai Med Univ, Dept Gastroenterol & Hepatol, 2-5-1 Shin Machi, Hirakata, Osaka 5731010, Japan.
EM yamaguct@hirakata.kmu.ac.jp; yoshidka@hirakata.kmu.ac.jp;
   muratami@takii.kmu.ac.jp; suwakan@hirakata.kmu.ac.jp;
   koichi.tsuneyama@gmail.com; matsuzak@takii.kmu.ac.jp;
   naganuma@hirakata.kmu.ac.jp
OI Suwa, Kanehiko/0000-0003-1986-7061; Yamaguchi,
   Takashi/0000-0003-0557-4321
FU JSPH KAKENHI [JP19K17415]
FX This research was funded by JSPH KAKENHI Grant Number JP19K17415.
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NR 170
TC 8
Z9 8
U1 0
U2 11
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD JUN
PY 2022
VL 23
IS 11
AR 6270
DI 10.3390/ijms23116270
PG 18
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 1Z5PY
UT WOS:000808877500001
PM 35682957
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Prasartthong, P
   Pakdeechote, P
   Maneesai, P
   Meephat, S
   Rattanakanokchai, S
   Wunpathe, C
   Apaijit, K
   Bunbupha, S
AF Prasartthong, Patoomporn
   Pakdeechote, Poungrat
   Maneesai, Putcharawipa
   Meephat, Sariya
   Rattanakanokchai, Siwayu
   Wunpathe, Chutamas
   Apaijit, Kwanjit
   Bunbupha, Sarawoot
TI Imperatorin attenuates cardiac remodelling and dysfunction in
   high-fat/high-fructose diet-fed rats by modulating oxidative stress,
   inflammation, and Nrf-2 expression
SO TISSUE & CELL
LA English
DT Article
DE Imperatorin; High-fat; high-fructose diet; Oxidative stress;
   Inflammation; Nuclear factor-erythroid 2-related factor 2
ID METABOLIC SYNDROME; HIGH-FAT; ACTIVATION
AB Imperatorin, an active natural furocoumarin, exerts a wide range of biological activities. In the present study, the therapeutic effects of imperatorin on cardiac function and remodelling and the possible underlying mechanisms involved in high-fat/high-fructose diet (HFFD)-fed rats were investigated. Male Sprague-Dawley rats were fed a high-fat diet plus 15 % fructose in drinking water for 16 weeks. HFFD-fed rats were treated with imperatorin (15 or 30 mg/kg/day) for the last 4 weeks. Treatment of HFFD-fed rats with imperatorin significantly reduced dyslipidaemia, hyperinsulinaemia, and hypertension. Imperatorin markedly alleviated HFFD-induced cardiac morphology alterations and left ventricular (LV) dysfunction. Imperatorin also significantly decreased malondialdehyde concentration and increased catalase activity in plasma and cardiac tissue. Additionally, decreased plasma tumour necrosis factor-alpha and interleukin-6 concentrations, together with restoration of cardiac nuclear factor-erythroid 2-related factor 2 (Nrf-2) protein expression, were also observed after treatment with imperatorin. These findings indicated that imperatorin alleviates HFFD-induced cardiac remodelling and LV dysfunction in rats. The possible underlying mechanism may involve the reduction of oxidative stress and inflammation, and the restoration of Nrf-2 expression.
C1 [Prasartthong, Patoomporn; Pakdeechote, Poungrat; Maneesai, Putcharawipa; Meephat, Sariya] Khon Kaen Univ, Fac Med, Dept Physiol, Khon Kaen 40002, Thailand.
   [Rattanakanokchai, Siwayu] Khon Kaen Univ, Fac Vet Med, Khon Kaen 40002, Thailand.
   [Wunpathe, Chutamas] Navamindradhiraj Univ, Fac Med, Vajira Hosp, Dept Basic Med Sci, Bangkok 10300, Thailand.
   [Apaijit, Kwanjit; Bunbupha, Sarawoot] Mahasarakham Univ, Fac Med, Maha Sarakham 44000, Thailand.
   [Pakdeechote, Poungrat] Khon Kaen Univ, Res Inst Human High Performance & Hlth Promot, Khon Kaen 40002, Thailand.
C3 Khon Kaen University; Khon Kaen University; Mahasarakham University;
   Khon Kaen University
RP Bunbupha, S (corresponding author), Mahasarakham Univ, Fac Med, Maha Sarakham 44000, Thailand.
EM sarawoot.b@msu.ac.th
RI Maneesai, Putcharawipa/AAK-4258-2021
OI Maneesai, Putcharawipa/0000-0003-0889-6211; Wunpathe,
   Chutamas/0000-0002-7973-2137
FU Faculty of Medicine, Mahasarakham University, Thailand [Med.
   Msu.6301011]
FX This research project was financially supported by a grant from the
   Faculty of Medicine, Mahasarakham University, Thailand (Med.
   Msu.6301011). The authors thank Dr. Adrian Roderick Plant for valuable
   suggestions and language editing of the manuscript.
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NR 31
TC 10
Z9 10
U1 0
U2 8
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0040-8166
J9 TISSUE CELL
JI Tissue Cell
PD APR
PY 2022
VL 75
AR 101728
DI 10.1016/j.tice.2021.101728
EA JAN 2022
PG 7
WC Anatomy & Morphology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Anatomy & Morphology; Cell Biology
GA 0A1IQ
UT WOS:000773715500003
PM 34998165
DA 2025-06-11
ER

PT J
AU Hamada, S
   Takata, T
   Yamada, K
   Yamamoto, M
   Mae, Y
   Iyama, T
   Ikeda, S
   Kanda, T
   Sugihara, T
   Isomoto, H
AF Hamada, Shintaro
   Takata, Tomoaki
   Yamada, Kentaro
   Yamamoto, Marie
   Mae, Yukari
   Iyama, Takuji
   Ikeda, Suguru
   Kanda, Tsutomu
   Sugihara, Takaaki
   Isomoto, Hajime
TI Steatosis is involved in the progression of kidney disease in a
   high-fat-diet-induced non-alcoholic steatohepatitis mouse model
SO PLOS ONE
LA English
DT Article
ID ENDOPLASMIC-RETICULUM STRESS; DIABETES-MELLITUS; NRF2 ACTIVATORS;
   EXPRESSION; APOPTOSIS; GLUCOSE; OBESITY; NAFLD
AB Chronic kidney disease (CKD) and non-alcoholic steatohepatitis (NASH) are major health issues associated with the metabolic syndrome. Although NASH is a known risk factor of CKD, the mechanisms linking these two diseases remain poorly understood. We aimed to investigate alterations in the kidney complicated with dyslipidemia in an established NASH mouse model. Male C57BL6/J mice were fed with control diet or high-fat diet (HFD), containing 40% fat, 22% fructose, and 2% cholesterol for 16 weeks. Metabolic characteristics, histological changes in the kidney, endoplasmic reticulum (ER) stress, apoptosis, and fibrosis were evaluated by histological analysis, immunoblotting, and quantitative reverse transcription-polymerase chain reaction. Levels of serum aspartate aminotransferase, alanine aminotransferase, alkali-phosphatase, total cholesterol, and urinary albumin were significantly higher in mice fed with HFD. Remarkable steatosis, glomerular hypertrophy, and interstitial fibrosis were also shown in in the kidney by leveraging HFD. Furthermore, HFD increased the mRNA expression levels of Casp3, Tgfb1, and Nfe2l2 and the protein level of BiP. We observed the early changes of CKD and speculate that the underlying mechanisms that link CKD and NASH are the induction of ER stress and apoptosis. Further, we observed the activation of Nfe2l2 in the steatosis-induced CKD mouse model. This NASH model holds implications in investigating the mechanisms linking dyslipidemia and CKD.
C1 [Hamada, Shintaro; Takata, Tomoaki; Yamada, Kentaro; Yamamoto, Marie; Mae, Yukari; Iyama, Takuji; Ikeda, Suguru; Kanda, Tsutomu; Sugihara, Takaaki; Isomoto, Hajime] Tottori Univ, Fac Med, Div Gastroenterol & Nephrol, Yonago, Tottori, Japan.
C3 Tottori University
RP Takata, T (corresponding author), Tottori Univ, Fac Med, Div Gastroenterol & Nephrol, Yonago, Tottori, Japan.
EM t-takata@tottori-u.ac.jp
RI Takata, Tomoaki/AAC-9506-2020
OI Takata, Tomoaki/0000-0003-2959-6015; Kanda, Tsutomu/0000-0003-0409-9258
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NR 44
TC 14
Z9 14
U1 0
U2 4
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PY 2022
VL 17
IS 3
AR e0265461
DI 10.1371/journal.pone.0265461
PG 12
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 0H9KN
UT WOS:000779047400048
PM 35294499
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Guerra, RC
   Zuñiga-Muñoz, A
   Lans, VG
   Díaz-Díaz, E
   Betancourt, CAT
   Pérez-Torres, I
AF Cambray Guerra, Rebeca
   Zuniga-Munoz, Alejandra
   Guarner Lans, Veronica
   Diaz-Diaz, Eulises
   Tena Betancourt, Carlos Alberto
   Perez-Torres, Israel
TI Modulation of the Activities of Catalase, Cu-Zn, Mn Superoxide
   Dismutase, and Glutathione Peroxidase in Adipocyte from Ovariectomised
   Female Rats with Metabolic Syndrome
SO INTERNATIONAL JOURNAL OF ENDOCRINOLOGY
LA English
DT Article
ID OXIDATIVE STRESS; ADIPOSE-TISSUE; ANTIOXIDANT ENZYMES; VASCULAR
   REACTIVITY; OXIDANT STRESS; RISK-FACTORS; OBESITY; INFLAMMATION;
   ASSOCIATION; ESTRADIOL
AB The aim of this study was to evaluate the association between estrogen removal, antioxidant enzymes, and oxidative stress generated by obesity in a MS female rat model. Thirty two female Wistar rats were divided into 4 groups: Control (C), MS, MS ovariectomized (Ovx), and MS Ovx plus estradiol (E-2). MS was induced by administering 30% sucrose to drinking water for 24 weeks. After sacrifice, intra-abdominal fat was dissected; adipocytes were isolated and lipid peroxidation, non-enzymatic antioxidant capacity, and the activities of Cu-Zn andMn superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) were determined. There were no significant differences in the activities of Cu-Zn, Mn SOD, CAT, and GPx between the C and MS groups, but in the MS Ovx group there was a statistically significant decrease in the activities of these enzymes when compared to MS and MSOvx + E-2. The increased lipid peroxidation and nonenzymatic antioxidant capacity found in MS Ovx was significantly decreased when compared to MS and MS Ovx + E-2. In conclusion, the removal of E-2 by ovariectomy decreases the activity of the antioxidant enzymes in the intra-abdominal tissue of MS female rats; this is reflected by increased lipid peroxidation and decreased nonenzymatic antioxidant capacity.
C1 [Cambray Guerra, Rebeca; Zuniga-Munoz, Alejandra; Perez-Torres, Israel] Inst Nacl Cardiol Ignacio Chavez, Dept Pathol, Mexico City 14080, DF, Mexico.
   [Guarner Lans, Veronica] Inst Nacl Cardiol Ignacio Chavez, Dept Physiol, Mexico City 14080, DF, Mexico.
   [Diaz-Diaz, Eulises] Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Reprod Biol, Mexico City 14000, DF, Mexico.
   [Tena Betancourt, Carlos Alberto] Inst Nacl Cardiol Ignacio Chavez, Dept Vivarium, Mexico City 14080, DF, Mexico.
C3 National Institute of Cardiology - Mexico; National Institute of
   Cardiology - Mexico; Instituto Nacional de Ciencias Medicas y Nutricion
   Salvador Zubiran - Mexico; National Institute of Cardiology - Mexico
RP Pérez-Torres, I (corresponding author), Inst Nacl Cardiol Ignacio Chavez, Dept Pathol, Juan Badiano 1,Sec XVI, Mexico City 14080, DF, Mexico.
EM pertorisr@yahoo.com.mx
RI Pérez Torres, Israel/AAE-2579-2022; Guarner-Lans, Verónica/AFW-3723-2022
OI Guarner-Lans, Veronica/0000-0002-2655-7590; Perez-Torres,
   Israel/0000-0001-6510-2954; Zuniga-Munoz, Alejandra
   Maria/0000-0002-0522-9395
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NR 63
TC 26
Z9 26
U1 1
U2 12
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1687-8337
EI 1687-8345
J9 INT J ENDOCRINOL
JI Int. J. Endocrinol.
PY 2014
VL 2014
AR 175080
DI 10.1155/2014/175080
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA AJ0UQ
UT WOS:000337372000001
PM 24987414
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Guarnieri, G
   Barazzoni, R
AF Guarnieri, Gianfranco
   Barazzoni, Rocco
TI Fighting Protein-Energy Wasting in Chronic Kidney Disease: A Challenge
   of Complexity
SO JOURNAL OF RENAL NUTRITION
LA English
DT Article; Proceedings Paper
CT 15th International Congress on Renal Nutrition and Metabolism (ICRNM)
CY MAY 25-28, 2010
CL Lausanne, SWITZERLAND
SP Int Soc Renal Nutr & Metab
ID CHRONIC-RENAL-FAILURE; HUMAN ADIPOSE-TISSUE; SERUM LEPTIN LEVELS;
   SKELETAL-MUSCLE; INSULIN-RESISTANCE; OXIDATIVE STRESS; TNF-ALPHA;
   ADIPONECTIN EXPRESSION; PERITONEAL-DIALYSIS; METABOLIC SYNDROME
AB Chronic uremia is often characterized by wasting of muscle and fat mass, which has been defined as protein-energy wasting (PEW), and is responsible for substantial worsening of patient outcome in terms of morbidity and mortality, mostly from cardiovascular events. Despite major advances in patient treatment, nutritional outcome in patients with end-stage renal disease has not improved substantially in recent years. Extensive research in this field has provided plausible explanations for this limitation by indicating that the pathogenesis of PEW in kidney disease is complex and multifactorial. Complexity involves underlying metabolic alterations, including inflammation, oxidative stress, and insulin resistance. In addition, patient heterogeneity is increasing with large numbers of obese individuals as a result of the ongoing obesity epidemics. Several tissues are involved in cross-talk and contribute to metabolic derangements, including adipose tissue, the gut, and the central nervous system, with novel mediators including the gastric hormone ghrelin. Acknowledging its complex pathogenesis may favor the development of novel and more effective therapeutic tools for PEW. These should ideally be effective in treating the underlying common mechanisms of wasting, which appear to include oxidative stress, inflammation, and insulin resistance. (C) 2011 by the National Kidney Foundation, Inc. All rights reserved.
C1 [Guarnieri, Gianfranco; Barazzoni, Rocco] Univ Trieste, Dept Med Technol & Translat Sci, Med Clin, I-34100 Trieste, Italy.
C3 University of Trieste
RP Guarnieri, G (corresponding author), Univ Trieste, Dept Med Technol & Translat Sci, Med Clin, Osped Cattinara, Str Fiume 447, I-34100 Trieste, Italy.
EM guarnier@units.it
RI Guarnieri, Giovanni/ABE-8112-2020
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NR 59
TC 12
Z9 12
U1 0
U2 3
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 1051-2276
EI 1532-8503
J9 J RENAL NUTR
JI J. Renal Nutr.
PD JAN
PY 2011
VL 21
IS 1
BP 2
EP 6
DI 10.1053/j.jrn.2010.10.008
PG 5
WC Nutrition & Dietetics; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Nutrition & Dietetics; Urology & Nephrology
GA 700XT
UT WOS:000285779600002
PM 21195908
DA 2025-06-11
ER

PT J
AU Silva, TS
   Longui, CA
   Faria, CDC
   Rocha, MN
   Melo, MR
   Faria, TG
   Almeida, JADE
   Hayashi, LF
   Kater, CE
AF Silva, T. S.
   Longui, C. A.
   Faria, C. D. C.
   Rocha, M. N.
   Melo, M. R.
   Faria, T. G.
   de Souza e Almeida, J. A.
   Hayashi, L. F.
   Kater, C. E.
TI Impact of Prolonged Physical Training on the Pituitary Glucocorticoid
   Sensitivity Determined by Very Low Dose Intravenous Dexamethasone
   Suppression Test
SO HORMONE AND METABOLIC RESEARCH
LA English
DT Article
DE HPA axis; glucocorticoid action; bioelectrical impedance; exercise;
   negative feedback
ID METABOLIC SYNDROME; ADRENAL AXIS; TISSUE SENSITIVITY; STRESS; EXERCISE;
   EXPRESSION; CHILDREN; OBESITY; IL-6
AB The activity of the hypothalamic-pituitary-adrenal axis is usually modulated by several stress factors, including exercise. Different responses are induced by physical training according to duration and intensity of exercise. During prolonged training, cortisol remains normal or decreased as a consequence of altered cortisol secretion, metabolism and excretion, and possibly by changes in glucocorticoid sensitivity. The aim of this study was to evaluate the impact of prolonged physical training on the glucocorticoid sensitivity. Eighteen cadets of the Air Force Academy, mean (SD) age: 18.7 (1.0) years, underwent an intensive 6-week preparatory training-period considered adequate by inducing significant changes on body composition measured by bioelectrical impedance. Measurement of individual's pituitary glucocorticoid sensitivity was done by an intravenous very low dose dexamethasone suppression test (20 mu g/m(2)) that was performed before and after the training period. Cortisol levels were obtained at basal condition and 120 minutes after the dexamethasone infusion. Basal cortisol showed a significant decrease after prolonged training. The percent cortisol suppression after dexamethasone tended to be lower after the training period. Overall, our data suggest that prolonged physical training is able to reduce glucocorticoid sensitivity, which can have a beneficial impact in chronic stress conditions.
C1 [Silva, T. S.; Longui, C. A.; Faria, C. D. C.; Rocha, M. N.; Melo, M. R.] Santa Casa Sao Paulo Fac Med Sci, Dept Physiol, Mol Med Lab, Sao Paulo, Brazil.
   [Faria, T. G.; de Souza e Almeida, J. A.] Brazilian AF Acad Pirassununga, Sao Paulo, Brazil.
   [Hayashi, L. F.; Kater, C. E.] Univ Fed Sao Paulo, Lab Steroids, Div Endocrinol, Dept Med, Sao Paulo, Brazil.
C3 Universidade Federal de Sao Paulo (UNIFESP)
RP Longui, CA (corresponding author), Rua Dr Cesario Motta Jr,112 Vila Buarque Sao Paul, Sao Paulo, Brazil.
EM carloslongui@msn.com
RI Longui, Carlos/B-8112-2013; Rocha, Mylene/F-4211-2012; Sousa e Silva,
   Tatiane/B-7862-2013; Melo, Murilo/F-4255-2012
OI Melo, Murilo/0000-0003-1105-5384; Silva, Tatiane/0000-0002-9254-7411
FU Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
   [04/03208-2]
FX The authors thank the Fundacao de Amparo a Pesquisa do Estado de Sao
   Paulo (FAPESP) for grant support, process # 04/03208-2.
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NR 36
TC 9
Z9 11
U1 0
U2 7
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0018-5043
EI 1439-4286
J9 HORM METAB RES
JI Horm. Metab. Res.
PD OCT
PY 2008
VL 40
IS 10
BP 718
EP 721
DI 10.1055/s-2008-1078727
PG 4
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 362UE
UT WOS:000260221800011
PM 18553256
DA 2025-06-11
ER

PT J
AU Crescenzo, R
   Bianco, F
   Mazzoli, A
   Giacco, A
   Cancelliere, R
   di Fabio, G
   Zarrelli, A
   Liverini, G
   Iossa, S
AF Crescenzo, Raffaella
   Bianco, Francesca
   Mazzoli, Arianna
   Giacco, Antonia
   Cancelliere, Rosa
   di Fabio, Giovanni
   Zarrelli, Armando
   Liverini, Giovanna
   Iossa, Susanna
TI Fat Quality Influences the Obesogenic Effect of High Fat Diets
SO NUTRIENTS
LA English
DT Article
DE high fat diet; unsaturated fatty acids; hepatic steatosis; lipid
   peroxidation
ID INSULIN-RESISTANCE; METABOLIC SYNDROME; HEPATIC STEATOSIS; OXIDATIVE
   STRESS; BODY-WEIGHT; RAT-LIVER; ADIPOSE-TISSUE; OBESITY; ACIDS;
   MITOCHONDRIA
AB High fat and/or carbohydrate intake are associated with an elevated risk for obesity and chronic diseases such as diabetes and cardiovascular diseases. The harmful effects of a high fat diet could be different, depending on dietary fat quality. In fact, high fat diets rich in unsaturated fatty acids are considered less deleterious for human health than those rich in saturated fat. In our previous studies, we have shown that rats fed a high fat diet developed obesity and exhibited a decrease in oxidative capacity and an increase in oxidative stress in liver mitochondria. To investigate whether polyunsaturated fats could attenuate the above deleterious effects of high fat diets, energy balance and body composition were assessed after two weeks in rats fed isocaloric amounts of a high-fat diet (58.2% by energy) rich either in lard or safflower/linseed oil. Hepatic functionality, plasma parameters, and oxidative status were also measured. The results show that feeding on safflower/linseed oil diet attenuates the obesogenic effect of high fat diets and ameliorates the blood lipid profile. Conversely, hepatic steatosis and mitochondrial oxidative stress appear to be negatively affected by a diet rich in unsaturated fatty acids.
C1 [Crescenzo, Raffaella; Bianco, Francesca; Mazzoli, Arianna; Giacco, Antonia; Cancelliere, Rosa; Liverini, Giovanna; Iossa, Susanna] Univ Naples Federico II, Dept Biol, I-80138 Naples, Italy.
   [di Fabio, Giovanni; Zarrelli, Armando] Univ Naples Federico II, Dept Chem Sci, I-80138 Naples, Italy.
   [Zarrelli, Armando] Interuniv Consortium SannioTech, I-82030 Apollosa, BN, Italy.
C3 University of Naples Federico II; University of Naples Federico II
RP Iossa, S (corresponding author), Univ Naples Federico II, Dept Biol, Via Cinthia, I-80138 Naples, Italy.
EM rcrescen@unina.it; francibianco@yahoo.it; arimazzoli@hotmail.it;
   antonia.giacco@hotmail.it; cancelliererosa@gmail.com; difabio@unina.it;
   zarrelli@unina.it; liverini@unina.it; susiossa@unina.it
RI Zarrelli, Armando/N-4379-2016; Di Fabio, Giovanni/Q-5808-2016; IOSSA,
   Susanna/O-1625-2016
OI mazzoli, arianna/0000-0003-4096-443X; Di Fabio,
   Giovanni/0000-0003-2912-4827; Zarrelli, Armando/0000-0001-7866-821X;
   IOSSA, Susanna/0000-0001-6103-718X
FU University "Federico II" of Naples
FX The authors thank Emilia de Santis for skillful management of the animal
   house. This work was supported by a grant from University "Federico II"
   of Naples.
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NR 49
TC 38
Z9 43
U1 3
U2 36
PU MDPI AG
PI BASEL
PA POSTFACH, CH-4005 BASEL, SWITZERLAND
SN 2072-6643
J9 NUTRIENTS
JI Nutrients
PD NOV
PY 2015
VL 7
IS 11
BP 9475
EP 9491
DI 10.3390/nu7115480
PG 17
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA CX4GJ
UT WOS:000365656900041
PM 26580650
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Kambey, PA
   Kodzo, LD
   Serojane, F
   Oluwasola, BJ
AF Kambey, Piniel Alphayo
   Kodzo, Lalit Dzifa
   Serojane, Fattimah
   Oluwasola, Bolorunduro Janet
TI The bi-directional association between bipolar disorder and obesity:
   Evidence from Meta and bioinformatics analysis
SO INTERNATIONAL JOURNAL OF OBESITY
LA English
DT Article
ID BODY-MASS INDEX; ATTENTION-DEFICIT/HYPERACTIVITY DISORDER;
   POSTTRAUMATIC-STRESS-DISORDER; EARLY-ONSET OBESITY; METABOLIC SYNDROME;
   PARAVENTRICULAR NUCLEUS; MEDICAL CONDITIONS; PI3K/AKT PATHWAY;
   MENTAL-HEALTH; METAANALYSIS
AB BackgroundThe globally high prevalence of both obesity and bipolar disorder makes the bidirectional relationship between the two disorders a pivotal phenomenon; hence, a meta-analysis to synopsize their co-occurrence is indispensable. Psychotropic-induced obesity has been reported to be an important factor linking bipolar disorder and obesity. Nonetheless, the molecular signature of this connection is perplexing.MethodsHere, we leverage both meta-analysis and bioinformatics analysis to provide a conspectus and deduce the molecular signature of obesity in bipolar disease patients following psychotropic treatment. Searches were performed on a diverse collection of databases through June 25, 2020. The Newcastle-Ottawa Scale was used to rate the quality of the studies. Analysis of OR, 95% CI, and tests of homogeneity were carried out with STATA software. For the bioinformatics analysis, the LIMMA package which is incorporated into the Gene Expression Omnibus database was used.ResultsOur search yielded 138 studies, of which 18 fitted our inclusion criteria. Individuals who are obese have an increased risk of developing bipolar disorder (pooled adjusted OR = 1.32, 95% CI = 1.01-1.62). In a manner analogous to this, the pooled adjusted odds ratio reveals that patients with bipolar disorder have an increased chance of obesity (OR = 1.68, 95% CI = 1.35-2). To deduce the molecular signature of obesity in bipolar disorder patients following psychotropic treatment, three data sets from the Gene Expression Omnibus database (GSE5392, GSE87610, and GSE35977) were integrated and the genes obtained were validated by a cohort of known single nucleotide polymorphism of obesity via direct overlap. Results indicate genes that are activated after psychotropic treatment. Some of these genes are CYBB, C3, OLR1, CX3CR1, C3AR1, CD53, AIF1, LY86, BDNF, ALOX5AP, CXCL10, and the preponderance falls under mesodermal and PI3K-Akt signaling pathway. The ROC analysis reveals a strong discriminating value between the two groups (UBAP2L AUC = 0.806, p = 1.1e-04, NOVA2 AUC = 0.73, p = 6.7e-03).ConclusionOur study shows unequivocal evidence of a bi-directional association between bipolar disorder and obesity, but more crucially, it provides a snapshot of the molecular signature of obesity in bipolar patients as a result of psychotropic medication.
C1 [Kambey, Piniel Alphayo; Kodzo, Lalit Dzifa; Serojane, Fattimah; Oluwasola, Bolorunduro Janet] Org African Acad Doctors OAAD, Off Kamiti Road,POB 25305-00100, Nairobi 00100, Kenya.
   [Kodzo, Lalit Dzifa] Zhengzhou Univ, Sch Nursing & Hlth, Zhengzhou, Henan, Peoples R China.
   [Kodzo, Lalit Dzifa] Nursing & Midwifery Training Coll, Twifo Praso, Central, Ghana.
   [Serojane, Fattimah] Southern Med Univ, Guangzhou, Peoples R China.
   [Oluwasola, Bolorunduro Janet] Harbin Inst Technol, Departure Comp Sci & Technol, 92,Xidazhi St, Harbin 150001, Peoples R China.
C3 Zhengzhou University; Southern Medical University - China; Harbin
   Institute of Technology
RP Kambey, PA (corresponding author), Org African Acad Doctors OAAD, Off Kamiti Road,POB 25305-00100, Nairobi 00100, Kenya.
EM pinielalphayo@yahoo.com
RI Kambey, Piniel/HLH-2606-2023; KODZO, LALIT/LXA-4177-2024
OI Kodzo, Lalit Dzifa/0000-0002-6374-8716; Kambey,
   Piniel/0000-0003-2436-0943
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NR 77
TC 9
Z9 9
U1 1
U2 5
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0307-0565
EI 1476-5497
J9 INT J OBESITY
JI Int. J. Obes.
PD JUN
PY 2023
VL 47
IS 6
BP 443
EP 452
DI 10.1038/s41366-023-01277-6
EA FEB 2023
PG 10
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA H0BL0
UT WOS:000936222700002
PM 36806758
DA 2025-06-11
ER

PT J
AU Hamer, M
   Molloy, GJ
   de Oliveira, C
   Demakakos, P
AF Hamer, Mark
   Molloy, Gerard J.
   de Oliveira, Cesar
   Demakakos, Panayotes
TI Persistent depressive symptomatology and inflammation: To what extent do
   health behaviours and weight control mediate this relationship?
SO BRAIN BEHAVIOR AND IMMUNITY
LA English
DT Article
DE Depression; C-reactive protein; Cardiovascular risk; Physical activity;
   Smoking; Alcohol
ID CORONARY-HEART-DISEASE; C-REACTIVE PROTEIN; RISK-FACTORS;
   CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; BODY-COMPOSITION; OLDER
   PERSONS; MARKERS; SYMPTOMS; ASSOCIATION
AB We examined if persistent depressive symptoms are associated with markers of inflammation (C-Reactive Protein-CRP) and coagulation (fibrinogen), and if this association can be partly explained by weight control and behavioural risk factors (smoking, alcohol, physical activity). The study sample included 3609 men and women (aged 60.5 +/- 9.2 years) from The English Longitudinal Study of Ageing, a prospective study of community dwelling older adults. Depressive symptoms (using the 8-item CES-D scale), health behaviours (smoking, alcohol, physical activity), body weight, and central adiposity were assessed at baseline and 2 years follow up. CRP and fibrinogen were assessed at follow up. At baseline 12.7% of the sample reported elevated depressive symptomatology, which persisted in 6.1% of participants at follow up. Baseline CES-D score was associated with CRP (beta = .035, SE = .0066) and fibrinogen (beta = .023, SE = .0060) measured 2 years later. Using simple mediation analysis we observed both a direct association of depressive symptoms on CRP (beta = .013, SE = .0066) and indirect mediating effects through behavioural risk factors (beta for total indirect effect beta = .022, SE = .0023). For fibrinogen there were no direct effects of depression, and the association was entirely explained through indirect mediating effects of health behaviours. The presence of recurrent elevated depressive symptomatology at both time points was more strongly associated with CRP and fibrinogen. In summary, the association between depressive symptoms and low grade inflammation can be partly explained by behavioural risk factors. The presence of persistent depression appears to be associated with the greatest risk of elevated inflammation. (C) 2009 Elsevier Inc. All rights reserved.
C1 [Hamer, Mark; Molloy, Gerard J.; de Oliveira, Cesar; Demakakos, Panayotes] UCL, Dept Epidemiol & Publ Hlth, London WC1E 6BT, England.
C3 University of London; University College London
RP Hamer, M (corresponding author), UCL, Dept Epidemiol & Publ Hlth, 1-19 Torrington Pl, London WC1E 6BT, England.
EM m.hamer@ucl.ac.uk
RI de Oliveira, Cesar/B-5251-2019; Molloy, Gerard/C-5721-2008; Hamer,
   Mark/C-1602-2008
OI Demakakos, Panayotes/0000-0002-7663-2122; De Oliveira,
   Cesar/0000-0002-4099-4762; Molloy, Gerard/0000-0002-7718-9898; Hamer,
   Mark/0000-0002-8726-7992
FU British Heart Foundation, UK; National Institute on Aging in the United
   States [2RO1AG7644-01A1, 2RO1AG017644]; ELSA; Archive; Office for
   National Statistics
FX Drs Hamer and Molloy are funded by the British Heart Foundation, UK. The
   data were made available through the UK Data Archive. The English
   Longitudinal Study of Ageing (ELSA) was developed by a team of
   researchers based at University College London, the Institute of Fiscal
   Studies, and the National Centre for Social Research. The funding is
   provided by the National Institute on Aging in the United States (Grants
   2RO1AG7644-01A1 and 2RO1AG017644) and a consortium of UK government
   departments coordinated by the Office for National Statistics. The
   funders had no role in the study design; in the collection, analysis,
   and interpretation of data; in writing of the report; and in the
   decision to submit the paper for publication. The developers and funders
   of ELSA and the Archive do not bear any responsibility for the analyses
   or interpretations presented here.
CR [Anonymous], HLTH SURV ENGL PHYS
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NR 46
TC 66
Z9 73
U1 0
U2 8
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0889-1591
J9 BRAIN BEHAV IMMUN
JI Brain Behav. Immun.
PD MAY
PY 2009
VL 23
IS 4
BP 413
EP 418
DI 10.1016/j.bbi.2009.01.005
PG 6
WC Immunology; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Neurosciences & Neurology; Psychiatry
GA 433XT
UT WOS:000265239800003
PM 19486658
DA 2025-06-11
ER

PT J
AU Lang, F
   Jilani, K
   Lang, E
AF Lang, Florian
   Jilani, Kashif
   Lang, Elisabeth
TI Therapeutic potential of manipulating suicidal erythrocyte death
SO EXPERT OPINION ON THERAPEUTIC TARGETS
LA English
DT Review
DE anemia; chronic kidney disease; diabetes; eryptosis; malaria; sickle
   cell disease; thrombosis
ID RED-BLOOD-CELLS; INDUCED PHOSPHATIDYLSERINE TRANSLOCATION; MEMBRANE
   PHOSPHOLIPID ORGANIZATION; CHRONIC KIDNEY-DISEASE;
   PLASMODIUM-FALCIPARUM; OXIDATIVE STRESS; NITRIC-OXIDE; ERYPTOTIC
   ERYTHROCYTES; FETAL-HEMOGLOBIN; BETA-THALASSEMIA
AB Introduction: Eryptosis, the suicidal erythrocyte death, is characterized by erythrocyte shrinkage and phosphatidylserine translocation to the erythrocyte surface. Eryptosis is triggered by cell stress such as energy depletion and oxidative stress, by Ca2+-entry, ceramide, caspases, calpain and/or altered activity of several kinases. Phosphatidylserine-exposing erythrocytes adhere to the vascular wall and may thus impede microcirculation. Eryptotic cells are further engulfed by phagocytes and thus rapidly cleared from circulation.
   Areas covered: Stimulation of eryptosis contributes to anemia of several clinical conditions such as metabolic syndrome, diabetes, malignancy, hepatic failure, heart failure, uremia, hemolytic uremic syndrome, sepsis, fever, dehydration, mycoplasma infection, malaria, iron deficiency, sickle cell anemia, thalassennia, glucose-6-phosphate dehydrogenase deficiency and Wilson's disease. On the other hand, eryptosis with subsequent clearance of infected erythrocytes in malaria may counteract parasitemia.
   Expert opinion: In theory, anemia due to excessive eryptosis could be alleviated by treatment with small molecules inhibiting eryptosis. In malaria, stimulators of eryptosis may accelerate death of infected erythrocytes and thus favorably influence the clinical course of the disease. Many small molecules inhibit or stimulate eryptosis. Several stimulators favorably influence murine malaria. Further preclinical and subsequent clinical studies are required to elucidate the therapeutic potential of stimulators or inhibitors of eryptosis.
C1 [Lang, Florian] Univ Tubingen, Dept Physiol, D-72076 Tubingen, Germany.
   [Jilani, Kashif] Univ Agr Faisalabad, Dept Biochem, Faisalabad 38040, Pakistan.
   [Lang, Elisabeth] Univ Dusseldorf, Dept Gastroenterol Hepatol & Infect Dis, Dusseldorf, Germany.
C3 Eberhard Karls University of Tubingen; University of Agriculture
   Faisalabad; Heinrich Heine University Dusseldorf
RP Lang, F (corresponding author), Univ Tubingen, Dept Physiol, Gmelinstr 5, D-72076 Tubingen, Germany.
EM florian.lang@uni-tuebingen.de
RI Jilani, Kashif/D-6151-2015
OI Jilani, Kashif/0000-0002-1761-4100
FU Deutsche Forschungsgemeinschaft
FX Research in the authors' laboratory was supported by the Deutsche
   Forschungsgemeinschaft. The sponsor(s) had no role in study design,
   collection, writing, analysis and interpretation of data, and in the
   decision to submit the article for publication. The authors have no
   relevant affiliations or financial involvement with any organization or
   entity with a financial interest in or financial conflict with the
   subject matter or materials discussed in the manuscript. This includes
   During employment, consultancies, honoraria, stock ownership or options,
   expert testimony, grants or patents received or pending, or royalties.
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NR 100
TC 22
Z9 22
U1 0
U2 20
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1472-8222
EI 1744-7631
J9 EXPERT OPIN THER TAR
JI Expert Opin. Ther. Targets
PD SEP
PY 2015
VL 19
IS 9
BP 1219
EP 1227
DI 10.1517/14728222.2015.1051306
PG 9
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA CP9AG
UT WOS:000360185500006
PM 26013571
DA 2025-06-11
ER

PT J
AU Ku, BJ
   Ko, K
   Shin, KO
   Bae, JY
AF Ku, Beom-Jun
   Ko, Kangeun
   Shin, Ki-Ok
   Bae, Ju-Yong
TI Effect of Regular Taekwondo Self-Defense Training on Oxidative Stress
   and Inflammation Markers in Postmenopausal Women
SO HEALTHCARE
LA English
DT Article
DE antioxidant enzymes; exercise; lipid profile; martial arts; physical
   fitness; reactive oxygen species
ID METABOLIC SYNDROME; IMPACT; MEN
AB We aimed to investigate the effect of a 12-week Taekwondo self-defense training course on oxidative stress and inflammation in postmenopausal women. Sixteen middle-aged women participated and were randomized into two groups: a control group (CG, n = 8) and a Taekwondo self-defense training group (TSDG, n = 8). The TSDG was trained for 60 min, four times per week, for 12 weeks. Following the Taekwondo training intervention, side-step was significantly higher in the TSDG than in the CG (p < 0.001). Malondialdehyde levels were significantly lower after the intervention than before in the TSDG (p < 0.01). Superoxide dismutase (SOD) levels were also significantly higher after the intervention than before in the TSDG (p < 0.001). After the Taekwondo training intervention, SOD levels were significantly higher in the TSDG than in the CG (p < 0.01). Tumor necrosis factor ff (TNF-alpha) levels were significantly lower after the intervention than before in the TSDG (p < 0.05). After the Taekwondo training intervention, TNF-alpha levels were significantly lower in the TSDG than in the CG (p < 0.05). The results of this study suggest that Taekwondo self-defense training is an effective exercise that improves agility, oxidative stress, and inflammatory responses in postmenopausal women.
C1 [Ku, Beom-Jun; Shin, Ki-Ok] Dong A Univ, Coll Arts & Phys Educ, Dept Taekwondo, Busan 49315, South Korea.
   [Ko, Kangeun; Shin, Ki-Ok; Bae, Ju-Yong] Dong A Univ, Dept Phys Educ, Lab Exercise Biochem, Coll Arts & Phys Educ, Busan 49315, South Korea.
C3 Dong A University; Dong A University
RP Shin, KO (corresponding author), Dong A Univ, Coll Arts & Phys Educ, Dept Taekwondo, Busan 49315, South Korea.; Shin, KO; Bae, JY (corresponding author), Dong A Univ, Dept Phys Educ, Lab Exercise Biochem, Coll Arts & Phys Educ, Busan 49315, South Korea.
EM kbj72621@naver.com; kku0803@naver.com; kshin21@dau.ac.kr;
   kosa99@dau.ac.kr
OI Bae, Ju Yong/0000-0003-4155-2250
FU Dong-A University research fund
FX This work was supported by the Dong-A University research fund.
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NR 42
TC 1
Z9 1
U1 0
U2 6
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2227-9032
J9 HEALTHCARE-BASEL
JI Healthcare
PD AUG
PY 2021
VL 9
IS 8
AR 985
DI 10.3390/healthcare9080985
PG 11
WC Health Care Sciences & Services; Health Policy & Services
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services
GA UG5HS
UT WOS:000689283900001
PM 34442122
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Joe, Y
   Kim, S
   Kim, HJ
   Park, J
   Chen, Y
   Park, HJ
   Jekal, SJ
   Ryter, SW
   Kim, UH
   Chung, HT
AF Joe, Yeonsoo
   Kim, Sena
   Kim, Hyo Jeong
   Park, Jeongmin
   Chen, Yingqing
   Park, Hyeok-Jun
   Jekal, Seung-Joo
   Ryter, Stefan W.
   Kim, Uh Hyun
   Chung, Hun Taeg
TI FGF21 induced by carbon monoxide mediates metabolic homeostasis via the
   PERK/ATF4 pathway
SO FASEB JOURNAL
LA English
DT Article
DE hepatic steatosis; metabolic disease; ER stress; ROS; thermogenic genes
ID GROWTH-FACTOR 21; ENDOPLASMIC-RETICULUM-STRESS; HEME OXYGENASE-1/CARBON
   MONOXIDE; ENDOTHELIAL-CELL APOPTOSIS; UNFOLDED PROTEIN RESPONSE; INSULIN
   SENSITIVITY; HEPATIC STEATOSIS; GLUCOSE-HOMEOSTASIS; PPAR-ALPHA; MICE
AB The prevalence of metabolic diseases, including type 2 diabetes, obesity, and cardiovascular disease, has rapidly increased, yet the molecular mechanisms underlying the metabolic syndrome, a primary risk factor, remain incompletely understood. The small, gaseous molecule carbon monoxide (CO) has well-known anti-inflammatory, antiproliferative, and antiapoptotic effects in a variety of cellular- and tissue-injury models, whereas its potential effects on the complex pathways of metabolic disease remain unknown. We demonstrate here that CO can alleviate metabolic dysfunction in vivo and in vitro. We show that CO increased the expression and section of the fibroblast growth factor 21 (FGF21) in hepatocytes and liver. CO-stimulated PERK activation and enhanced the levels of FGF21 via the eIF2 alpha-ATF4 signaling pathway. The induction of FGF21 by CO attenuated endoreticulum stress- or diet-induced, obesity-dependent hepatic steatosis. Moreover, CO inhalation lowered blood glucose levels, enhanced insulin sensitivity, and promoted energy expenditure by stimulating the emergence of beige adipose cells from white adipose cells. In conclusion, we suggest that CO acts as a potent inducer of FGF21 expression and that CO critically depends on FGF21 to regulate metabolic homeostasis.
C1 [Joe, Yeonsoo; Kim, Sena; Kim, Hyo Jeong; Park, Jeongmin; Chen, Yingqing; Park, Hyeok-Jun; Chung, Hun Taeg] Univ Ulsan, Sch Biol Sci, Meta Inflammat Res Inst Basic Res, Bldg 35,Room 807, Ulsan, South Korea.
   [Jekal, Seung-Joo] Wonkwang Hlth Sci Univ, Iksan, Jeonbuk, South Korea.
   [Ryter, Stefan W.] Weill Cornell Med, Joan & Sanford I Weill Dept Med, Div Pulm & Crit Care Med, New York, NY USA.
   [Kim, Uh Hyun] Chonbuk Natl Univ, Med Sch, Natl Creat Res Lab Signaling Network Ca2, Jeonju 54896, South Korea.
C3 University of Ulsan; Cornell University; Weill Cornell Medicine; Jeonbuk
   National University
RP Chung, HT (corresponding author), Univ Ulsan, Sch Biol Sci, Meta Inflammat Res Inst Basic Res, Bldg 35,Room 807, Ulsan, South Korea.; Kim, UH (corresponding author), Chonbuk Natl Univ, Med Sch, Natl Creat Res Lab Signaling Network Ca2, Jeonju 54896, South Korea.
EM uhkim@chonbuk.ac.kr; chung@ulsan.ac.kr
RI Kim, Yoon/J-2746-2012; Chen, Yingqing/AAH-1367-2020; Kim, You
   Sun/B-2881-2015
OI Kim, Sena/0000-0002-6930-2416; Kim, Uh-Hyun/0000-0003-3304-7190; Chen,
   Yingqing/0000-0003-2326-7587
FU Priority Research Centers Program through the National Research
   Foundation of Korea (NRF) - Ministry of Education [2014R1A6A1030318];
   Bio and Medical Technology Development Program of the NRF - Ministry of
   Science, Information and Communications Technology (ICT), and Future
   Planning [2012M3A9C3048687, NRF-2012R1A3A2026453]
FX This work was supported by Priority Research Centers Program through the
   National Research Foundation of Korea (NRF), funded by the Ministry of
   Education (Grant 2014R1A6A1030318) and the Bio and Medical Technology
   Development Program of the NRF, funded by the Ministry of Science,
   Information and Communications Technology (ICT), and Future Planning
   (Grants 2012M3A9C3048687 to H.T.C., and NRF-2012R1A3A2026453 to U.H.K).
   The authors declare no conflicts of interest.
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NR 53
TC 42
Z9 45
U1 1
U2 10
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
EI 1530-6860
J9 FASEB J
JI Faseb J.
PD MAY
PY 2018
VL 32
IS 5
BP 2630
EP 2643
DI 10.1096/fj.201700709RR
PG 14
WC Biochemistry & Molecular Biology; Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GG2MW
UT WOS:000432528000026
PM 29295856
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Yu, JS
   Marsh, S
   Hu, JB
   Feng, WK
   Wu, CD
AF Yu, Jinsheng
   Marsh, Sharon
   Hu, Junbo
   Feng, Wenke
   Wu, Chaodong
TI The Pathogenesis of Nonalcoholic Fatty Liver Disease: Interplay between
   Diet, Gut Microbiota, and Genetic Background
SO GASTROENTEROLOGY RESEARCH AND PRACTICE
LA English
DT Review
ID ENDOPLASMIC-RETICULUM STRESS; DE-NOVO LIPOGENESIS; INCREASED INTESTINAL
   PERMEABILITY; GREATER-THAN-G; INSULIN-RESISTANCE; HEPATIC STEATOSIS;
   METABOLIC SYNDROME; HEPATOCELLULAR-CARCINOMA; CONFERS SUSCEPTIBILITY;
   FRUCTOSE CONSUMPTION
AB Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in the world, and it comprises a spectrum of hepatic abnormalities from simple hepatic steatosis to steatohepatitis, fibrosis, cirrhosis, and liver cancer. While the pathogenesis of NAFLD remains incompletely understood, a multihit model has been proposed that accommodates causal factors from a variety of sources, including intestinal and adipose proinflammatory stimuli acting on the liver simultaneously. Prior cellular and molecular studies of patient and animal models have characterized several common pathogenic mechanisms of NAFLD, including proinflammation cytokines, lipotoxicity, oxidative stress, and endoplasmic reticulum stress. In recent years, gut microbiota has gained much attention, and dysbiosis is recognized as a crucial factor in NAFLD. Moreover, several genetic variants have been identified through genome-wide association studies, particularly rs738409 (Ile748Met) in PNPLA3 and rs58542926 (Glu167Lys) in TM6SF2, which are critical risk alleles of the disease. Although a high-fat diet and inactive lifestyles are typical risk factors for NAFLD, the interplay between diet, gut microbiota, and genetic background is believed to be more important in the development and progression of NAFLD. This review summarizes the common pathogenic mechanisms, the gut microbiota relevant mechanisms, and the major genetic variants leading to NAFLD and its progression.
C1 [Yu, Jinsheng] Washington Univ, Sch Med, Dept Genet, St Louis, MO 63110 USA.
   [Marsh, Sharon] Univ Alberta, Fac Pharm & Pharmaceut Sci, Edmonton, AB T6G 2H7, Canada.
   [Hu, Junbo] Huazhong Sci & Technol Univ, Tongji Hosp, Dept Gen Surg, Wuhan 430030, Hubei, Peoples R China.
   [Feng, Wenke] Univ Louisville, Dept Med, Louisville, KY 40208 USA.
   [Wu, Chaodong] Texas A&M Univ, Dept Nutr & Food Sci, Houston, TX 77843 USA.
C3 Washington University (WUSTL); University of Alberta; Huazhong
   University of Science & Technology; University of Louisville; Texas A&M
   University System
RP Yu, JS (corresponding author), Washington Univ, Sch Med, Dept Genet, St Louis, MO 63110 USA.
EM jyu@wustl.edu
RI 於, 金生/AAO-5331-2020
OI Marsh, Sharon/0009-0005-9363-4110
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NR 145
TC 152
Z9 169
U1 2
U2 20
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1687-6121
EI 1687-630X
J9 GASTROENT RES PRACT
JI Gastroenterol. Res. Pract.
PY 2016
VL 2016
AR 2862173
DI 10.1155/2016/2862173
PG 13
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA DM4MI
UT WOS:000376321000001
PM 27247565
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Guo, C
   Li, R
   Zheng, N
   Xu, LY
   Liang, T
   He, QL
AF Guo, Chao
   Li, Rong
   Zheng, Ni
   Xu, Lingyuan
   Liang, Tao
   He, Qiaoling
TI Anti-diabetic effect of ramulus mori polysaccharides, isolated from
   Morus alba L., on STZ-diabetic mice through blocking inflammatory
   response and attenuating oxidative stress
SO INTERNATIONAL IMMUNOPHARMACOLOGY
LA English
DT Article
DE Ramulus mori polysaccharides; Glycemia; Inflammation; Oxidative stress
ID HYPERGLYCEMIC HYPEROSMOLAR STATE; INSULIN-RESISTANCE;
   EUROPEAN-ASSOCIATION; CONSENSUS STATEMENT; METABOLIC SYNDROME; HEME
   OXYGENASE-1; MELLITUS; MANAGEMENT; MECHANISMS; THERAPY
AB Diabetes mellitus is a clinically complex disease characterized by the dysfunctions of pancreas. In this study, we investigated the therapeutic effects of ramulus mori polysaccharides (RMP) on diabetic mice induced by streptozotocin. Our results showed that body weight and insulin level were notably increased after metformin and RMP treatments, while the blood glucose was lowered. HE-staining assay showed that the treatments mitigated the pathological lesions in pancreas tissue. In addition, the expression levels of tumor necrosis factor-a (TNF-alpha), interleukin-8 (IL-8), interleukin-6 (IL-6) and cyclo-oxygenase-2 (COX-2) were effectively reduced in pancreas tissue by the treatments, respectively. We also found that upon these treatments, the activities of manganese superoxide dismutase (MnSOD) and glutathione reductase (GSH-Rd) were increased; the content of malonaldehyde (MDA) was decreased in pancreas tissue; and the mRNA expression of heme oxygenase-1 (HO-1) was markedly increased in pancreas tissue. Taken together, these results suggest that RMP plays the blood glucose-lowering and metabolism-normalizing roles, and it may improve the function of pancreas through inhibiting the inflammatory response and attenuating the oxidative stress in pancreas tissue. (C) 2013 Elsevier B.V. All rights reserved.
C1 [Guo, Chao] Guangxi Med Univ, Affiliated Hosp 8, Guigang City Peoples Hosp, Guigang 537100, Guangxi, Peoples R China.
   [Xu, Lingyuan] Youjiang Med Univ Nationalities, Affiliated Hosp, Ctr Clin Lab, Baise 533000, Guangxi, Peoples R China.
   [Li, Rong] Guilin Med Univ, Guilin 541004, Guangxi, Peoples R China.
   [Zheng, Ni; Liang, Tao; He, Qiaoling] Guangxi Med Univ, Nanning 530021, Peoples R China.
C3 Guangxi Medical University; Youjiang Medical University for
   Nationalities; Guilin Medical University; Guangxi Medical University
RP Xu, LY (corresponding author), Youjiang Med Univ Nationalities, Affiliated Hosp, Ctr Clin Lab, 18 Zhongshan Rd 2, Baise 533000, Guangxi, Peoples R China.
EM xulingyuan168@163.com
RI He, Qiaoling/JXM-7827-2024
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NR 42
TC 67
Z9 78
U1 0
U2 66
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1567-5769
EI 1878-1705
J9 INT IMMUNOPHARMACOL
JI Int. Immunopharmacol.
PD MAY
PY 2013
VL 16
IS 1
BP 93
EP 99
DI 10.1016/j.intimp.2013.03.029
PG 7
WC Immunology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Pharmacology & Pharmacy
GA 165PR
UT WOS:000320496300013
PM 23566811
DA 2025-06-11
ER

PT J
AU Pérez-Pérez, R
   Ortega-Delgado, FJ
   García-Santos, E
   López, JA
   Camafeita, E
   Ricart, W
   Fernández-Real, JM
   Peral, B
AF Perez-Perez, Rafael
   Ortega-Delgado, Francisco J.
   Garcia-Santos, Eva
   Lopez, Juan A.
   Camafeita, Emilio
   Ricart, Wifredo
   Fernandez-Real, Jose-Manuel
   Peral, Belen
TI Differential Proteomics of Omental and Subcutaneous Adipose Tissue
   Reflects Their Unalike Biochemical and Metabolic Properties
SO JOURNAL OF PROTEOME RESEARCH
LA English
DT Article
DE obesity; adipose tissue; omental fat; subcutaneous fat; mesothelial
   cells; metabolic syndrome; 2D-DIGE; proteomics; MALDI-TOF/TOF
ID ACID-BINDING PROTEIN; ENDOPLASMIC-RETICULUM STRESS; INSULIN-RESISTANCE;
   GEL-ELECTROPHORESIS; MASS-SPECTROMETRY; OBESE SUBJECTS; DECREASED
   EXPRESSION; MESOTHELIAL CELLS; PRIMARY CULTURES; ENERGY-BALANCE
AB Obesity is increasing exponentially in developed countries and constitutes a public health problem by enhancing the risk for metabolic disorder and cardiovascular disease. Differences in gene expression profiles and in metabolic and biochemical properties have been well-described between omental and subcutaneous adipose tissue in humans. Because omental adipose tissue has been strongly associated with the development of insulin resistance, type 2 diabetes and cardiovascular disease, we searched for proteins differentially expressed in these two fat depots using two-dimensional fluorescence difference gel electrophoresis (2D-DIGE) and mass spectrometry (MS). In this analysis, we found 43 proteins, several of which were validated by immunoblotting and immunostaining analyses. Results demonstrated tissue-specific molecular differences in the protein makeup of the two analyzed fat depots mainly related to metabolic processes such as glucose and lipid metabolism, lipid transport, protein synthesis, protein folding, response to stress and inflammation. This suggests higher metabolic activity as well as increased cell stress in the omental compared to the subcutaneous fat. These findings provide some insights into the role of omental fat in abdominal obesity-associated co-morbidities.
C1 [Perez-Perez, Rafael; Garcia-Santos, Eva; Peral, Belen] CSIC, Inst Invest Biomed, E-28029 Madrid, Spain.
   [Perez-Perez, Rafael; Garcia-Santos, Eva; Peral, Belen] Univ Autonoma Madrid, E-28029 Madrid, Spain.
   [Ortega-Delgado, Francisco J.; Ricart, Wifredo; Fernandez-Real, Jose-Manuel] Hosp Dr Josep Trueta, Dept Diabet Endocrinol & Nutr, E-17007 Girona, Spain.
   [Ortega-Delgado, Francisco J.; Ricart, Wifredo; Fernandez-Real, Jose-Manuel] Hosp Dr Josep Trueta, CIBEROBN Fisiopatol Obesidad & Nutr, E-17007 Girona, Spain.
   [Lopez, Juan A.; Camafeita, Emilio] CNIC, Unidad Prote, E-28029 Madrid, Spain.
C3 Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Instituto
   de Investigaciones Biomedicas Alberto Sols (IIBM); Autonomous University
   of Madrid; Universitat de Girona; Girona University Hospital Dr. Josep
   Trueta; CIBER - Centro de Investigacion Biomedica en Red; CIBEROBN;
   Universitat de Girona; Girona University Hospital Dr. Josep Trueta;
   Centro Nacional de Investigaciones Cardiovasculares (CNIC)
RP Peral, B (corresponding author), CSIC, Inst Invest Biomed, Arturo Duperier 4, E-28029 Madrid, Spain.
EM bperal@iib.uam.es
RI Fernández-Real, Jose Manuel/AGH-3599-2022; Lopez, Juan/JCD-9404-2023;
   Ortega, Francisco Jose/F-3883-2016; PERAL, BELEN/F-4562-2015; Lopez,
   Juan Antonio/G-7750-2015
OI Fernandez-Real, Jose Manuel/0000-0002-7442-9323; Ortega, Francisco
   Jose/0000-0003-2111-769X; Ricart, Wifredo/0000-0002-3452-9098; PERAL,
   BELEN/0000-0003-4984-4020; Perez-Perez, Rafael/0000-0001-7726-5873;
   Lopez, Juan Antonio/0000-0002-9097-6060
FU Ministerio de Educacion y Ciencia, Spain [SAF-2006-02354,
   SAF-2008-02073]; Spanish Ministry of Science and Innovation; Pro CNIC
   Foundation
FX This work was supported by Grant SAF-2006-02354 and Grant SAF-2008-02073
   from the Ministerio de Educacion y Ciencia, Spain. We thank Cristina
   Gomez for her technical help, Dr. David Hardisson for assistance with
   immunohistochemical analysis, Dr. Fatima Sanchez-Cabo for statistical
   advice, and Dr. Jose Luis Martin-Ventura. We also acknowledge all the
   patients included in this study. The CNIC is supported by the Spanish
   Ministry of Science and Innovation and the Pro CNIC Foundation. CIBER is
   an initiative from the Instituto de Salud Carlos III.
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NR 66
TC 81
Z9 88
U1 1
U2 9
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1535-3893
EI 1535-3907
J9 J PROTEOME RES
JI J. Proteome Res.
PD APR
PY 2009
VL 8
IS 4
SI SI
BP 1682
EP 1693
DI 10.1021/pr800942k
PG 12
WC Biochemical Research Methods
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 429NU
UT WOS:000264928200009
PM 19714809
DA 2025-06-11
ER

PT J
AU Kullisaar, T
   Shepetova, J
   Zilmer, K
   Songisepp, E
   Rehema, A
   Mikelsaar, M
   Zilmer, M
AF Kullisaar, Tiiu
   Shepetova, Jelena
   Zilmer, Kersti
   Songisepp, Epp
   Rehema, Aune
   Mikelsaar, Marika
   Zilmer, Mihkel
TI An antioxidant probiotic reduces postprandial lipemia and oxidative
   stress
SO CENTRAL EUROPEAN JOURNAL OF BIOLOGY
LA English
DT Article
DE Postprandial period; Oxidative stress; Postprandial lipemic response;
   Probiotics; Lactobacillus fermentum; Oxidized low-density lipoprotein;
   Paraoxonase, isoprostanes
ID LACTOBACILLUS-FERMENTUM ME-3; CARDIOVASCULAR-DISEASE;
   DENSITY-LIPOPROTEIN; METABOLIC SYNDROME; ATHEROSCLEROSIS; PARAOXONASE;
   MECHANISMS; BACTERIA; ADULTS; RISK
AB Reducing postprandial oxidative stress (OxS), decreasing postprandial blood triglyceride level (TG) and improving lipoprotein status is likely to have a preventive impact on the development of cardiovascular disease (CVD). Previously we have shown that the antioxidant probiotic Lactobacillus fermentum ME-3 (DSM14241) is characterized by antiatherogenic effects. This randomized double-blind placebo-controlled study evaluated the influence of kefir enriched with an antioxidative probiotic L. fermentum ME-3 (LfKef) on postprandial OxS, blood TG response and lipoprotein status. 100 clinically healthy subjects were recruited into the study. Blood parameters of postprandial OxS, TG and lipoprotein status were determined by oxidized LDL, baseline diene conjugation in LDL (BDC-LDL), oxidized LDL complex with beta-2 glycoprotein (Beta2-GPI-oxLDL), paraoxonase (PON) activity, LDL-Chol, HDL-Chol and TG. To evaluate general body postprandial OxS-load we measured 8-isoprostanes (8-EPI) in the urine. Consumption of LfKef significantly reduced the postprandial level of oxidized LDL, BDC-LDL, Beta2-GPI-oxLDL, urinary 8-isoprostanes and postprandial TG and caused a significant increase in HDL-Chol and PON activity. This is the first evidence that kefir enriched with an antioxidant probiotic may have a positive effect on both postprandial OxS and TG response as well as on lipoprotein status.
C1 [Kullisaar, Tiiu] Univ Tartu, Fac Med, Dept Biochem, Biomedicum, EE-50411 Tartu, Estonia.
   [Shepetova, Jelena; Mikelsaar, Marika] Univ Tartu, Fac Med, Dept Microbiol, EE-50411 Tartu, Estonia.
   [Kullisaar, Tiiu; Songisepp, Epp] Biocompetence Ctr Healthy Dairy Prod, EE-50411 Tartu, Estonia.
   [Kullisaar, Tiiu; Zilmer, Kersti; Rehema, Aune; Zilmer, Mihkel] Ctr Excellence Translat Med, EE-50411 Tartu, Estonia.
C3 University of Tartu; University of Tartu
RP Kullisaar, T (corresponding author), Univ Tartu, Fac Med, Dept Biochem, Biomedicum, EE-50411 Tartu, Estonia.
EM tiiu.kullisaar@ut.ee
FU Estonian Science Foundation [6588]; Ministry of Education and Science of
   Estonia [TARBK0411]; European Union
FX Estonian Science Foundation (grant 6588); Targeted financing of The
   Ministry of Education and Science of Estonia (TARBK0411) and by the
   European Union through the European Regional Development Fund.
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NR 38
TC 27
Z9 30
U1 0
U2 24
PU DE GRUYTER POLAND SP ZOO
PI WARSAW
PA BOGUMILA ZUGA 32A STR., 01-811 WARSAW, POLAND
SN 1895-104X
EI 1644-3632
J9 CENT EUR J BIOL
JI Cent. Eur. J. Biol.
PD FEB
PY 2011
VL 6
IS 1
BP 32
EP 40
DI 10.2478/s11535-010-0103-4
PG 9
WC Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics
GA 702WD
UT WOS:000285925700005
OA hybrid
DA 2025-06-11
ER

PT J
AU Hosseini, H
   Ghavidel, F
   Rajabian, A
   Homayouni-Tabrizi, M
   Majeed, M
   Sahebkar, A
AF Hosseini, Hossein
   Ghavidel, Farideh
   Rajabian, Arezoo
   Homayouni-Tabrizi, Masoud
   Majeed, Muhammed
   Sahebkar, Amirhossein
TI The Effects of Curcumin Plus Piperine Co-administration on Inflammation
   and Oxidative Stress: A Systematic Review and Meta-analysis of
   Randomized Controlled Trials
SO CURRENT MEDICINAL CHEMISTRY
LA English
DT Article; Early Access
DE Curcumin; piperine; inflammation; antioxidant; meta-analysis
ID QUALITY-OF-LIFE; METABOLIC SYNDROME; SULFUR MUSTARD; POTENTIAL ROLE;
   DOUBLE-BLIND; IN-VITRO; ANTIOXIDANT; SUPPLEMENTATION; CANCER;
   BIOAVAILABILITY
AB Background The beneficial effects of curcumin against various chronic disorders have been shown in the last few decades. However, due to its low bioavailability, therapeutic effects are less than expected. Piperine has been used in scientific evaluations as an effective compound to increase the bioavailability of curcumin. The present review investigated the impact of curcumin plus piperine intake on oxidative stress and inflammatory markers of Randomized Clinical Trials (RCTs).Methods Using relevant keywords, we searched Cochrane Library, Scopus, PubMed, and Web of Science between January 1st, 1970, and September 30th, 2022. A comprehensive search for RCTs was performed. Continuous data were pooled by Standard Mean Difference (SMD) and 95% confidence interval. All related statistical analyses were performed using Comprehensive Meta-Analysis (CMA) software.Results A total of 13 articles were incorporated into the final meta-analysis. According to the current meta-analysis, curcumin plus piperine administration showed a significantly increased SOD activity and GSH levels while significantly decreased MDA concentrations. In addition, our study revealed that curcumin plus piperine significantly decreased TNF-alpha and IL-6 concentrations.Conclusion These results indicated that curcumin plus piperine administration could effectively reduce oxidative stress and inflammation.
C1 [Hosseini, Hossein; Ghavidel, Farideh] Mashhad Univ Med Sci, Fac Med, Dept Clin Biochem, Mashhad, Iran.
   [Rajabian, Arezoo] Mashhad Univ Med Sci, Fac Med, Dept Internal Med, Mashhad, Iran.
   [Homayouni-Tabrizi, Masoud] Islamic Azad Univ, Dept Biol, Mashhad Branch, Mashhad, Iran.
   [Majeed, Muhammed] Sami Sabinsa Grp Ltd, 19-1&19-2,I Main,2 Phase, Bengaluru 560058, Karnataka, India.
   [Majeed, Muhammed] Sabinsa Corp, 20 Lake Dr, East Windsor, NJ 08520 USA.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Biotechnol Res Ctr, Mashhad, Iran.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Appl Biomed Res Ctr, Mashhad, Iran.
C3 Mashhad University of Medical Sciences; Mashhad University of Medical
   Sciences; Islamic Azad University; Mashhad University of Medical
   Sciences; Mashhad University of Medical Sciences
RP Sahebkar, A (corresponding author), Mashhad Univ Med Sci, Pharmaceut Technol Inst, Biotechnol Res Ctr, Mashhad, Iran.
EM amir_saheb2000@yahoo.com
RI Rajabian, Arezoo/ABE-9124-2021; Hosseini, Hossein/AAX-5350-2021;
   Sahebkar, Amirhossein/B-5124-2018; Tabrizi, Masoud/AAT-8929-2021
OI Ghavidel, Farideh/0000-0002-0324-3716
FX Declared none.
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NR 116
TC 4
Z9 4
U1 3
U2 7
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 0929-8673
EI 1875-533X
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JI Curr. Med. Chem.
PD 2024 MAR 29
PY 2024
DI 10.2174/0109298673260515240322074849
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WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Pharmacology &
   Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
GA C9X8O
UT WOS:001292828900001
PM 38561618
DA 2025-06-11
ER

PT J
AU Collao, N
   Farup, J
   De Lisio, M
AF Collao, Nicolas
   Farup, Jean
   De Lisio, Michael
TI Role of Metabolic Stress and Exercise in Regulating Fibro/Adipogenic
   Progenitors
SO FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
LA English
DT Review
DE obesity; metabolic syndrome; FAPs; differentiation; skeletal muscle;
   physical activity; exercise; mesenchymal stem cell
ID MESENCHYMAL STEM-CELLS; ADIPOSE-TISSUE DISTRIBUTION; SKELETAL-MUSCLE;
   INSULIN SENSITIVITY; SATELLITE CELLS; STROMAL CELLS; THIGH MUSCLE;
   FIBROSIS; FAT; RESISTANCE
AB Obesity is a major public health concern and is associated with decreased muscle quality (i.e., strength, metabolism). Muscle from obese adults is characterized by increases in fatty, fibrotic tissue that decreases the force producing capacity of muscle and impairs glucose disposal. Fibro/adipogenic progenitors (FAPs) are muscle resident, multipotent stromal cells that are responsible for muscle fibro/fatty tissue accumulation. Additionally, they are indirectly involved in muscle adaptation through their promotion of myogenic (muscle-forming) satellite cell proliferation and differentiation. In conditions similar to obesity that are characterized by chronic muscle degeneration, FAP dysfunction has been shown to be responsible for increased fibro/fatty tissue accumulation in skeletal muscle, and impaired satellite cell function. The role of metabolic stress in regulating FAP differentiation and paracrine function in skeletal muscle is just beginning to be unraveled. Thus, the present review aims to summarize the recent literature on the role of metabolic stress in regulating FAP differentiation and paracrine function in skeletal muscle, and the mechanisms responsible for these effects. Furthermore, we will review the role of physical activity in reversing or ameliorating the detrimental effects of obesity on FAP function.
C1 [Collao, Nicolas; De Lisio, Michael] Univ Ottawa, Sch Human Kinet, Ottawa, ON, Canada.
   [Farup, Jean] Aarhus Univ, Dept Biomed, Aarhus, Denmark.
   [De Lisio, Michael] Univ Ottawa, Ctr Neuromuscular Dis, Dept Cellular & Mol Med, Ottawa, ON, Canada.
C3 University of Ottawa; Aarhus University; University of Ottawa
RP De Lisio, M (corresponding author), Univ Ottawa, Sch Human Kinet, Ottawa, ON, Canada.; De Lisio, M (corresponding author), Univ Ottawa, Ctr Neuromuscular Dis, Dept Cellular & Mol Med, Ottawa, ON, Canada.
EM mdelisio@uottawa.ca
OI Farup, Jean/0000-0002-7579-6512
FU National Sciences and Engineering Research Council (NSERC); American
   Institute for Cancer Research (AICR); CONICYT-CHILE Doctoral Research
   Award
FX This work was supported by grants from the National Sciences and
   Engineering Research Council (NSERC), and the American Institute for
   Cancer Research (AICR) to MD. NC is the recipient of the CONICYT-CHILE
   Doctoral Research Award and the Doctoral Fellowship for Advancement of
   Biological Perspectives for Exercise Interventions Across the Lifespan.
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NR 128
TC 22
Z9 23
U1 2
U2 5
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-634X
J9 FRONT CELL DEV BIOL
JI Front. Cell. Dev. Biol.
PD JAN 28
PY 2020
VL 8
AR 9
DI 10.3389/fcell.2020.00009
PG 10
WC Cell Biology; Developmental Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Developmental Biology
GA MW1FX
UT WOS:000556793000001
PM 32047748
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Sahebkar, A
   Mohammadi, A
   Atabati, A
   Rahiman, S
   Tavallaie, S
   Iranshahi, M
   Akhlaghi, S
   Ferns, GAA
   Ghayour-Mobarhan, M
AF Sahebkar, Amirhossein
   Mohammadi, Akram
   Atabati, Ali
   Rahiman, Shamim
   Tavallaie, Shima
   Iranshahi, Mehrdad
   Akhlaghi, Saeed
   Ferns, Gordon A. A.
   Ghayour-Mobarhan, Majid
TI Curcuminoids Modulate Pro-Oxidant-Antioxidant Balance but not the Immune
   Response to Heat Shock Protein 27 and Oxidized LDL in Obese Individuals
SO PHYTOTHERAPY RESEARCH
LA English
DT Article
DE curcumin; heat shock protein 27; oxidized low-density lipoprotein;
   oxidative stress
ID CARDIOVASCULAR RISK-FACTORS; ANTIBODY-TITERS; METABOLIC SYNDROME;
   OXIDATIVE STRESS; CONTROLLED-TRIAL; DOUBLE-BLIND; PROOXIDANT;
   OVERWEIGHT; ASSOCIATION; PREVALENCE
AB Curcuminoids have potentially important functional qualities including anti-inflammatory and antioxidant properties. In this randomized double-blind placebo-controlled cross-over trial, the effects of a curcuminoid supplement on serum pro-oxidant-antioxidant balance (PAB) and antibody titres to Hsp27 (anti-Hsp27) and oxLDL (anti-oxLDL) were investigated. Thirty obese individuals were randomized to receive either curcuminoids (1 g/day) or placebo for a period of 30 days. After a wash-out period of 2 weeks, subjects were crossed over to the alternate regimen for another 30 days. Serum PAB along with anti-Hsp27 and anti-oxLDL titres was measured at the beginning and at the end of each study period. There was no significant carry-over effect for any of the assessed parameters. Curcuminoid supplementation was associated with a significant decrease in PAB (p=0.044). However, no significant change was observed in serum concentrations of anti-Hsp27 or anti-oxLDL (p>0.05). These findings suggest that oral curcuminoids supplementation (1g/day) is effective in reducing oxidative stress burden, though this needs to be validated in larger study populations. Copyright (c) 2013 John Wiley & Sons, Ltd.
C1 [Sahebkar, Amirhossein; Iranshahi, Mehrdad] Mashhad Univ Med Sci, Biotechnol Res Ctr, Mashhad 9177948564, Iran.
   [Sahebkar, Amirhossein; Iranshahi, Mehrdad] Mashhad Univ Med Sci, Sch Pharm, Mashhad 9177948564, Iran.
   [Sahebkar, Amirhossein; Mohammadi, Akram; Tavallaie, Shima; Ghayour-Mobarhan, Majid] Mashhad Univ Med Sci, Biochem & Nutr Res Ctr, Mashhad 9177948564, Iran.
   [Atabati, Ali; Rahiman, Shamim] Islamic Azad Univ, Mashhad branch, Sch Med, Mashhad, Iran.
   [Akhlaghi, Saeed] Mashhad Univ Med Sci, Fac Med, Mashhad 9177948564, Iran.
   [Ferns, Gordon A. A.] Univ Brighton, Brighton & Susssex Med Sch, Div Med Educ, Brighton BN1 9PH, Staffs, England.
   [Ghayour-Mobarhan, Majid] ACECR Mashhad Branch, Mol Med Res Dept, Mashhad, Iran.
C3 Mashhad University of Medical Sciences; Mashhad University of Medical
   Sciences; Mashhad University of Medical Sciences; Islamic Azad
   University; Mashhad University of Medical Sciences; University of
   Brighton
RP Ghayour-Mobarhan, M (corresponding author), Mashhad Univ Med Sci, Fac Med, Biochem Nutr Res Ctr, Mashhad 9177948564, Iran.
EM ghayourm@mums.ac.ir; ghayourm@mums.ac.ir
RI Iranshahi, Mehrdad/E-3664-2014; Ghayour-Mobarhan, Majid/AAY-5963-2020;
   Akhlaghi, Saeed/AAX-1767-2020; Sahebkar, Amirhossein/B-5124-2018
OI Akhlaghi, Saeed/0000-0002-1999-1209; Iranshahi,
   Mehrdad/0000-0002-3018-5750
FU Mashhad University of Medical Sciences
FX The authors acknowledge with grateful appreciation the kind assistance
   and financial support provided by the Vice Chancellor for Research at
   the Mashhad University of Medical Sciences.
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NR 57
TC 146
Z9 149
U1 0
U2 12
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0951-418X
EI 1099-1573
J9 PHYTOTHER RES
JI Phytother. Res.
PD DEC
PY 2013
VL 27
IS 12
BP 1883
EP 1888
DI 10.1002/ptr.4952
PG 6
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 268ZV
UT WOS:000328210400022
PM 23494802
DA 2025-06-11
ER

PT J
AU Damsgaard, CT
   Lauritzen, L
   Hauger, H
   Vuholm, S
   Teisen, MN
   Ritz, C
   Hansen, M
   Niclasen, J
   Molgaard, C
AF Damsgaard, Camilla T.
   Lauritzen, Lotte
   Hauger, Hanne
   Vuholm, Stine
   Teisen, Marie N.
   Ritz, Christian
   Hansen, Max
   Niclasen, Janni
   Molgaard, Christian
TI Effects of oily fish intake on cardiovascular risk markers, cognitive
   function, and behavior in school-aged children: study protocol for a
   randomized controlled trial
SO TRIALS
LA English
DT Article
DE n-3 PUFA; Child health; Dietary recommendations; Cognitive function;
   Cardiovascular risk factors; Mental health
ID LONG-CHAIN OMEGA-3-FATTY-ACIDS; BLOOD-PRESSURE; VITAMIN-D;
   DOCOSAHEXAENOIC ACID; METABOLIC SYNDROME; PHYSICAL-ACTIVITY; HEART-RATE;
   SUPPLEMENTATION; METAANALYSIS; CHILDHOOD
AB Background: Most children in Western populations do not meet recommendations for fish consumption. Oily fish is an important source of n-3 long-chain polyunsaturated fatty acids (LCPUFA), which reduce blood pressure and plasma triacylglycerol in adults and may affect cognitive development and behavior. However, to our knowledge, the potential effects of oily fish on cardiometabolic health, cognitive function, and behavior in children have not been investigated. The aim of the FiSK Junior study is to investigate the effects of oily fish consumption on cardiovascular risk markers, cognitive function, and behavior in healthy children.
   Methods/design: We are conducting a randomized controlled trial with 8- to 9-year-old Danish children, comparing the effect of consuming 300 g/week of oily fish with poultry (control) for 12 weeks between August 2016 and June 2017. The primary outcomes are blood pressure and fasting plasma triacylglycerol, which will be measured at baseline and endpoint. In addition, we will assess erythrocyte fatty acid composition (compliance), heart rate, plasma cholesterol, markers of glucose homeostasis, growth and body composition, dietary intake, and physical activity and sleep. We will also examine effects on cognitive function (attention, memory, and executive functions) by using standardized tests, behavior and emotions by administering parent-rated questionnaires and child interviews, and we will measure physiological stress response and cortisol levels. We need 150 children to complete the trial to detect a between-groups difference of 2.7 mmHg in diastolic blood pressure and 0.13 mmol/L in plasma triacylglycerol; thus, we aim to recruit 200 children. All outcomes will be analyzed in completer analysis supplemented with sensitivity analyses for the primary outcomes, and attention will be given to potential sex and genotype specificity.
   Discussion: The results of the FiSK Junior study are expected to fill important gaps in the current knowledge about the importance of dietary fish and n-3 LCPUFA for children's health and development, and may be used when setting dietary recommendations.
C1 [Damsgaard, Camilla T.; Lauritzen, Lotte; Hauger, Hanne; Vuholm, Stine; Teisen, Marie N.; Ritz, Christian; Molgaard, Christian] Univ Copenhagen, Fac Sci, Dept Nutr Exercise & Sports, Rolighedsvej 26, DK-1958 Frederiksberg C, Denmark.
   [Hansen, Max] Tech Univ Denmark, Natl Food Inst, Div Risk Assessment & Nutr, Soborg, Denmark.
   [Niclasen, Janni] Univ Copenhagen, Fac Social Sci, Dept Psychol, Copenhagen, Denmark.
   [Niclasen, Janni] Aarhus Univ, Ctr Collaborat Hlth, Aarhus C, Denmark.
C3 University of Copenhagen; Technical University of Denmark; University of
   Copenhagen; Aarhus University
RP Damsgaard, CT (corresponding author), Univ Copenhagen, Fac Sci, Dept Nutr Exercise & Sports, Rolighedsvej 26, DK-1958 Frederiksberg C, Denmark.
EM ctd@nexs.ku.dk
RI Teisen, Marie/P-7576-2019; Damsgaard, Camilla/B-4866-2015; Vuholm,
   Stine/P-7575-2019; Hauger, Hanne/B-6075-2015; Ritz,
   Christian/P-6159-2014; Lauritzen, Lotte/F-2921-2013; Molgaard,
   Christian/D-2052-2014
OI Hauger, Hanne/0000-0002-1680-587X; Vuholm, Stine/0000-0002-7074-5564;
   Damsgaard, Camilla T/0000-0002-5013-0562; Ritz,
   Christian/0000-0002-5095-0624; Lauritzen, Lotte/0000-0001-7184-5949;
   Teisen, Marie Nygaard/0000-0003-2500-5951; Molgaard,
   Christian/0000-0002-5311-9457
FU Nordea-fonden [02-2015-1429]
FX The FiSK Junior study is supported by Nordea-fonden (grant
   02-2015-1429). The funder did not have any role in the study design or
   the decision to publish this protocol. Study foods will be purchased
   from Skagenfood A/S, Sodam A/S via gaardmester.dk and REMA 1000 Danmark
   A/S with discount, and provided in kind by Amanda Seafoods A/S.
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NR 47
TC 11
Z9 12
U1 1
U2 33
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1745-6215
J9 TRIALS
JI Trials
PD OCT 21
PY 2016
VL 17
AR 510
DI 10.1186/s13063-016-1647-z
PG 8
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA DZ5HE
UT WOS:000385891800003
PM 27769289
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Arcos, D
   Russo, LN
   Kazmierski, KFM
   Zhou, E
   Montiel, GI
   Bracho, A
   Mejia, N
   Borelli, JL
AF Arcos, Daniela
   Russo, Lyric N.
   Kazmierski, Kelly F. M.
   Zhou, Elayne
   Montiel, Gloria Itzel
   Bracho, America
   Mejia, Nancy
   Borelli, Jessica L.
TI A Relationship-Based Resilience Program for Promotores: Protocol for a
   Randomized Controlled Waitlist Trial
SO JMIR RESEARCH PROTOCOLS
LA English
DT Article
DE psychosocial intervention; relational savoring; cardiometabolic health;
   community service providers; Hispanic or Latinx; CSP
ID HEALTH-CARE; DISPARITIES; DISCRIMINATION; BURNOUT; QUALITY; WORKERS;
   RISK
AB Background: Community service providers (CSPs) play an integral role in the health care of low-income Hispanic or Latinx (HL) communities. CSPs have high-stress frontline jobs and share the high-risk demographics of their communities. Relational savoring (RS) has been associated with lower cardiovascular reactivity and psychosocial benefits, with particular promise among HL participants. In this study, we aim to identify RS's potential in promoting CSPs' cardiometabolic health and, in so doing, having broader impacts on the community they serve. Objective: This randomized controlled waitlist study aims to examine the effect of an RS intervention on (1) CSPs' cardiometabolic health (cardiometabolic risk factors and outcomes) and (2) CSPs' threats to leaving the workforce. Methods: We will recruit a sample of 80 CSPs from community health agencies serving low-income HL populations. Participating CSPs will be randomized into an experimental or a waitlist control. Participants will complete 1 or 2 baseline assessment batteries (before the intervention), depending on the assigned group, and then complete 2 more assessment batteries following the 4-week RS intervention (after the intervention and at a 3-mo follow-up). The RS intervention consists of guided reflections on positive moments of connection with others. Electrocardiogram data will be obtained from a wearable device (Polar Verity Sense or Movisens) to measure heart rate variability. The primary outcome is cardiometabolic health, consisting of cardiometabolic risk (obtained from heart rate variability) and cardiometabolic health behaviors. The secondary outcomes include CSPs' threats to leaving the workforce (assessed via psychological well-being), intervention acceptability, and CSPs' delivery of cardiometabolic health programming to the community (exploratory). Analyses of covariance will be used to examine the effects of RS on cardiometabolic health and on CSPs' threats to leaving the workforce, comparing outcomes at baseline, postintervention, and at follow-up across participants in the experimental versus waitlist group. Results: The study has been approved by the University of California, Irvine, Institutional Review Board and is currently in the data collection phase. By May 2023, 37 HL CSPs have been recruited: 34 have completed the baseline assessment, 28 have completed the 4 intervention sessions, 27 have completed the posttreatment assessment, and 10 have completed all assessments (including the 3-mo follow-up). Conclusions: This study will provide valuable information on the potential of RS to support cardiometabolic health in HL CSPs and, indirectly, in the communities they serve.
C1 [Arcos, Daniela; Russo, Lyric N.; Kazmierski, Kelly F. M.; Borelli, Jessica L.] Univ Calif Irvine, Dept Psychol Sci, 401 E Peltason Dr, Irvine, CA 92617 USA.
   [Zhou, Elayne] Univ Southern Calif, Dept Psychol, Los Angeles, CA USA.
   [Montiel, Gloria Itzel; Bracho, America; Mejia, Nancy] Latino Hlth Access, Santa Ana, CA USA.
C3 University of California System; University of California Irvine;
   University of Southern California
RP Borelli, JL (corresponding author), Univ Calif Irvine, Dept Psychol Sci, 401 E Peltason Dr, Irvine, CA 92617 USA.
EM jessica.borelli@uci.edu
OI Arcos Hidalgo, Daniela/0000-0002-7634-8818; Zhou,
   Elayne/0000-0001-9604-9404; Kazmierski, Kelly/0000-0001-7914-7184;
   Montiel, Gloria/0000-0003-2540-1487; Russo, Lyric/0000-0002-3815-3622;
   Borelli, Jessica/0000-0001-8471-6732
FU University of California END DISPARITIES pilot award through the
   National Institute of Health or National Institute on Minority Health
   and Health Disparities [P50-MD017366, UL1TR001414]; National Center for
   Advancing Translational Sciences [UL1TR001414] Funding Source: NIH
   RePORTER; National Institute on Minority Health and Health Disparities
   [P50MD017366] Funding Source: NIH RePORTER
FX The authors thank their lead partner community health agency, Latino
   Health Access, for their contributions as well as other community health
   agencies that they will partner with in the future. This work was
   supported by a University of California END DISPARITIES pilot award
   through the National Institute of Health or National Institute on
   Minority Health and Health Disparities grant #P50-MD017366, National
   Institute of Health or National Center for Advancing Translational
   Sciences UC Irvine Institute for Clinical and Translational Science
   grant #UL1TR001414.
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NR 60
TC 2
Z9 2
U1 0
U2 0
PU JMIR PUBLICATIONS, INC
PI TORONTO
PA 130 QUEENS QUAY East, Unit 1100, TORONTO, ON M5A 0P6, CANADA
SN 1929-0748
J9 JMIR RES PROTOC
JI JMIR RES. Protoc.
PY 2023
VL 12
AR e51427
DI 10.2196/51427
PG 15
WC Health Care Sciences & Services; Public, Environmental & Occupational
   Health
WE Emerging Sources Citation Index (ESCI)
SC Health Care Sciences & Services; Public, Environmental & Occupational
   Health
GA GB5Q4
UT WOS:001150215300002
PM 38113093
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Dragoi, CM
   Nicolae, AC
   Ungurianu, A
   Margina, DM
   Gradinaru, D
   Dumitrescu, IB
AF Dragoi, Cristina Manuela
   Nicolae, Alina Crenguta
   Ungurianu, Anca
   Margina, Denisa Marilena
   Gradinaru, Daniela
   Dumitrescu, Ion-Bogdan
TI Circadian Rhythms, Chrononutrition, Physical Training, and Redox
   Homeostasis-Molecular Mechanisms in Human Health
SO CELLS
LA English
DT Review
DE circadian rhythm; oxidative stress; physical exercise; chronobiology;
   metabolism; redox homeostasis; chronotype; sport performance; sleep
ID SLEEP-WAKE CYCLE; OXIDATIVE STRESS; MELATONIN RHYTHM; ATHLETIC
   PERFORMANCE; METABOLIC SYNDROME; DIURNAL-VARIATION; GENE-EXPRESSION;
   GROWTH-HORMONE; BODY-WEIGHT; EXERCISE
AB A multitude of physiological processes, human behavioral patterns, and social interactions are intricately governed by the complex interplay between external circumstances and endogenous circadian rhythms. This multidimensional regulatory framework is susceptible to disruptions, and in contemporary society, there is a prevalent occurrence of misalignments between the circadian system and environmental cues, a phenomenon frequently associated with adverse health consequences. The onset of most prevalent current chronic diseases is intimately connected with alterations in human lifestyle practices under various facets, including the following: reduced physical activity, the exposure to artificial light, also acknowledged as light pollution, sedentary behavior coupled with consuming energy-dense nutriments, irregular eating frameworks, disruptions in sleep patterns (inadequate quality and duration), engagement in shift work, and the phenomenon known as social jetlag. The rapid evolution of contemporary life and domestic routines has significantly outpaced the rate of genetic adaptation. Consequently, the underlying circadian rhythms are exposed to multiple shifts, thereby elevating the susceptibility to disease predisposition. This comprehensive review endeavors to synthesize existing empirical evidence that substantiates the conceptual integration of the circadian clock, biochemical molecular homeostasis, oxidative stress, and the stimuli imparted by physical exercise, sleep, and nutrition.
C1 [Dragoi, Cristina Manuela; Nicolae, Alina Crenguta; Ungurianu, Anca; Margina, Denisa Marilena; Gradinaru, Daniela] Carol Davila Univ Med & Pharm, Fac Pharm, Dept Biochem, Bucharest 020956, Romania.
   [Dumitrescu, Ion-Bogdan] Carol Davila Univ Med & Pharm, Fac Pharm, Dept Phys & Informat, Bucharest 020956, Romania.
C3 Carol Davila University of Medicine & Pharmacy; Carol Davila University
   of Medicine & Pharmacy
RP Gradinaru, D (corresponding author), Carol Davila Univ Med & Pharm, Fac Pharm, Dept Biochem, Bucharest 020956, Romania.
EM cristina.dragoi@umfcd.ro; alina.nicolae@umfcd.ro;
   anca.ungurianu@umfcd.ro; denisa.margina@umfcd.ro;
   daniela.gradinaru@umfcd.ro; ion.dumitrescu@umfcd.ro
RI Gradinaru, Daniela/A-4952-2019; DRAGOI, Cristina Manuela/ABV-7637-2022;
   Ungurianu, Anca/U-5657-2019; Dumitrescu, Ion-Bogdan/T-1745-2019;
   Nicolae, Alina Crenguta/T-1055-2019; Margina, Denisa/J-7312-2013
OI Gradinaru, Daniela/0000-0001-7666-3108; Margina,
   Denisa/0000-0003-3289-147X; Dumitrescu, Ion-Bogdan/0000-0001-5693-8012;
   Nicolae, Alina Crenguta/0000-0002-4128-3882; DRAGOI, Cristina
   Manuela/0000-0002-6568-6846; Ungurianu, Anca/0000-0002-6887-1035
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NR 171
TC 18
Z9 18
U1 9
U2 30
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2073-4409
J9 CELLS-BASEL
JI Cells
PD JAN
PY 2024
VL 13
IS 2
AR 138
DI 10.3390/cells13020138
PG 27
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA FW2W8
UT WOS:001148835100001
PM 38247830
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Neviere, R
   Yu, YC
   Wang, L
   Tessier, F
   Boulanger, E
AF Neviere, Remi
   Yu, Yichi
   Wang, Lei
   Tessier, Frederic
   Boulanger, Eric
TI Implication of advanced glycation end products (Ages) and their receptor
   (Rage) on myocardial contractile and mitochondrial functions
SO GLYCOCONJUGATE JOURNAL
LA English
DT Review
DE Advanced glycation end products; Cardiovascular; Mitochondria; Signaling
   pathways
ID CROSS-LINK BREAKER; CIRCULATING SOLUBLE RECEPTOR;
   CORONARY-ARTERY-DISEASE; HEART-FAILURE PATIENTS; OXIDATIVE STRESS;
   ENDOTHELIAL FUNCTION; PLASMA-LEVELS; NITRIC-OXIDE; INSULIN-RESISTANCE;
   METABOLIC SYNDROME
AB Advanced glycation end products (AGEs) play an important role for the development and/or progression of cardiovascular diseases, mainly through induction of oxidative stress and inflammation. AGEs are a heterogeneous group of molecules formed by non-enzymatic reaction of reducing sugars with amino acids of proteins, lipids and nucleic acids. AGEs are mainly formed endogenously, while recent studies suggest that diet constitutes an important exogenous source of AGEs. The presence and accumulation of AGEs in various cardiac cell types affect extracellular and intracellular structure and function. AGEs contribute to a variety of microvascular and macrovascular complications through the formation of cross-links between molecules in the basement membrane of the extracellular matrix and by engaging the receptor for advanced glycation end products (RAGE). Activation of RAGE by AGEs causes up regulation of the transcription factor nuclear factor-kappa B and its target genes. of the RAGE engagement stimulates oxidative stress, evokes inflammatory and fibrotic reactions, which all contribute to the development and progression of devastating cardiovascular disorders. This review discusses potential targets of glycation in cardiac cells, and underlying mechanisms that lead to heart failure with special interest on AGE-induced mitochondrial dysfunction in the myocardium.
C1 [Neviere, Remi] Sch Med, Dept Physiol, Pole Rech 1,Pl Verdun, F-59045 Lille, France.
   [Neviere, Remi; Yu, Yichi; Wang, Lei; Tessier, Frederic; Boulanger, Eric] Univ Lille, Team Glycat Inflammat Aging, INSERM, LIRIC,U995, Villeneuve Dascq, France.
   [Yu, Yichi; Wang, Lei] Shanghai Jiao Tong Univ, Sch Med, Shanghai, Peoples R China.
C3 Universite de Lille; CHU Lille; Universite de Lille; Institut National
   de la Sante et de la Recherche Medicale (Inserm); Shanghai Jiao Tong
   University
RP Neviere, R (corresponding author), Sch Med, Dept Physiol, Pole Rech 1,Pl Verdun, F-59045 Lille, France.; Neviere, R (corresponding author), Univ Lille, Team Glycat Inflammat Aging, INSERM, LIRIC,U995, Villeneuve Dascq, France.
EM rneviere@univ-lille2.fr
RI ; tessier, frederic/G-3729-2018
OI Neviere, Remi/0000-0002-7966-0110; BOULANGER, Eric/0000-0002-5204-2849;
   tessier, frederic/0000-0001-8096-5715
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NR 103
TC 38
Z9 39
U1 1
U2 23
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0282-0080
EI 1573-4986
J9 GLYCOCONJUGATE J
JI Glycoconjugate J.
PD AUG
PY 2016
VL 33
IS 4
BP 607
EP 617
DI 10.1007/s10719-016-9679-x
PG 11
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA DT0FD
UT WOS:000381157600013
PM 27277623
DA 2025-06-11
ER

PT J
AU Ammann, P
   Naegeli, B
   Rickli, H
   Buchholz, S
   Mury, R
   Schuiki, E
   Bertel, O
AF Ammann, P
   Naegeli, B
   Rickli, H
   Buchholz, S
   Mury, R
   Schuiki, E
   Bertel, O
TI Characteristics of patients with abnormal stress technetium Tc 99m
   sestamibi SPELT studies without significant coronary artery diameter
   stenoses
SO CLINICAL CARDIOLOGY
LA English
DT Article
DE single-photon emission computed tomography; sestamibi; coronary artery
   disease; left ventricular hypertrophy; left bundle-branch block
ID BUNDLE-BRANCH-BLOCK; LEFT-VENTRICULAR HYPERTROPHY; MYOCARDIAL PERFUSION;
   DOBUTAMINE STRESS; HYPERTENSIVE PATIENTS; SYNDROME-X; SCINTIGRAPHY;
   DISEASE; ECHOCARDIOGRAPHY; TOMOGRAPHY
AB Background: Single-photon emission computed tomography (SPELT) sestamibi (MIBI) is an excellent tool for detection of coronary artery disease (CAD), preoperative risk assessment, and follow-up management after coronary revascularization. While the sensitivity of MIBI SPELT for detecting CAD has been reported to exceed 90%, the specificity ranges between 53-100%.
   Hypothesis: The study was undertaken to assess characteristics of patients with abnormal stress technetium Tc 99m sestamibi SPELT (MIBI) studies without significant coronary artery diameter stenoses (< 50%).
   Methods: Between January 1999 and November 2000, 270 consecutive patients were referred for coronary angiography due to reversible MIBI uptake defects during exercise. In 41 patients (15%; 39% women, mean age 59 9 years), reversible MIBI uptake defects were assessed although coronary angiography showed no significant CAD. These patients were compared with age- and gender-matched patients with perfusion abnormalities (39% women, mean age 60 9 years), due to significant CAD (coronary artery stenosis > 50%).
   Results: There were no significant differences between the two groups regarding body mass index, left bundle-branch block (LBBB), or method of stress test (dipyridamole in patients with LBBB or physical inactivity [n =11] and exercise in all the others [n = 30]). Left ventricular hypertrophy (44 vs. 23%; p = 0.05) and left anterior fascicular block (LAFB).(17 vs. 0%, p = 0.005) were more common in patients with perfusion abnormalities with no significant CAD, whereas ST segment depression during exercise (17 vs. 37% p = 0.05) and angina during exercise (15 vs. 29%, p = 0.02) were significantly less common than in patients with abnormal MIBI perfusion studies and angiographically significant CAD. Sestamibi uptake defects during exercise were significantly smaller in patients without significant CAD than in matched controls with significant CAD (p < 0.0004).
   Conclusion: Of 270 consecutive patients, 41(15 %) referred to coronary angiography due to reversible MIBI uptake defects showed coronary artery stenoses < 50%. Twenty-six (10%) of these presented angiographically normal coronary arteries. The significantly higher proportion of left ventricular hypertrophy and LAFB in patients with reversible MIBI uptake defects without significant CAD suggest microvascular disease, angiographically underestimated CAD, and conduction abnormalities as underlying mechanisms.
C1 Kantonsspital St Gallen, Dept Internal Med, Div Cardiol, CH-9000 St Gallen, Switzerland.
   Triemli Hosp, Dept Internal Med, Div Cardiol, Zurich, Switzerland.
C3 Kantonsspital St. Gallen; Triemli Hospital
RP Kantonsspital St Gallen, Dept Internal Med, Div Cardiol, CH-9000 St Gallen, Switzerland.
EM peter.ammann@kssg.ch
RI Ammann, Peter/IQW-5347-2023
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NR 16
TC 13
Z9 13
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0160-9289
EI 1932-8737
J9 CLIN CARDIOL
JI Clin. Cardiol.
PD NOV
PY 2003
VL 26
IS 11
BP 521
EP 524
DI 10.1002/clc.4960261109
PG 4
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 737QM
UT WOS:000186243300008
PM 14640468
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Tuncel, OK
   Altunkaynak, Z
   Bilgici, B
   Karaustaoglu, A
   Gumrukcuoglu, TI
AF Tuncel, Ozgur Korhan
   Altunkaynak, Zuhal
   Bilgici, Birsen
   Karaustaoglu, Arzu
   Gumrukcuoglu, Taner Ilker
TI Increased growth hormone secretagogue receptor-1a (GHSR-1a) in
   hypothalamus during olanzapine treatment in ratsy
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE Olanzapine; Valproic acid; Weigth gain; GHSR-1a; Ghrelin; Adipocytokines
ID INSULIN-RESISTANCE; METABOLIC SYNDROME; EPILEPTIC PATIENTS; BIPOLAR
   DISORDER; VALPROIC ACID; WEIGHT-GAIN; BODY-WEIGHT; SODIUM VALPROATE;
   PLASMA-LEVELS; TNF-ALPHA
AB Weight gain is the one of the most important factors which increases global burden of psychiatric disorder. Second-generation antipsychotics, olanzapine (Olz) and valproic acid (Vpa) in particular, are held responsible for weight gain. However, it is still uncertain how these drugs cause this. Thus, the rats selected for the experiment were randomly divided into 3 groups. The 1st group received only 0.5 ml saline solution intraperitoneally (n = 20, control group); the second group was given 200 mg / kg Vpa intraperitoneally (n = 20, Vpa group) and 2 mg / kg Olz was given intraperitoneally to the 3rd group (n = 20, Olz group) between 8 and 10 am for 30 days. We examined serum leptin, adiponectin, resistin, TNF-alpha, IL-6, ghrelin level and, the amount of ghrelin secreting cells in the stomach and growth hormone secretagogue receptor-1a (GHSR-1a, ghrelin receptor) expression in the hypothalamus. The hypothalamic GHS-1a receptor index was significantly higher in the Olz group compared with the control group and Vpa group (p = 0.036 and p = 0.016 respectively). Ghrelin immune positive cell index in stomach was statistically significantly lower in the Vpa group compared with the control and Olz groups (p = 0.028 and p = 0.013 respectively) There was no difference between the groups in terms of serum leptin, resistin, IL-6 and ghrelin levels. In the Vpa group, a statistically significant increase was found in serum adi-ponectin level compared with both the control group and the Olz group (p = 0009 and p = 0024 respectively) and, significant decrease was found in serum TNF-alpha level compared to Olz group (p = 0007). In conclusion, we found that the main cause of weight gain in Olz use was the increase in the number of hypothalamic ghrelin receptors. Investigating the mechanism by which Olz increases the number of ghrelin receptors may help to develop effective treatment strategies in preventing obesity in psychiatric patients.
C1 [Tuncel, Ozgur Korhan; Bilgici, Birsen; Karaustaoglu, Arzu; Gumrukcuoglu, Taner Ilker] Ondokuz Mayis Univ, Fac Med, Med Biochem Dept, TR-55139 Samsun, Turkey.
   [Altunkaynak, Zuhal] Ondokuz Mayis Univ, Fac Med, Histol & Embryol Dept, TR-55139 Samsun, Turkey.
   [Tuncel, Ozgur Korhan] Ondokuz Mayis Univ, Dept Med Biochem, Fac Med, TR-55139 Samsun, Turkey.
C3 Ondokuz Mayis University; Ondokuz Mayis University; Ondokuz Mayis
   University
RP Tuncel, OK (corresponding author), Ondokuz Mayis Univ, Dept Med Biochem, Fac Med, TR-55139 Samsun, Turkey.
EM ozgurkorhan@yahoo.com
RI Gümrükçüoğlu, Taner İlker/LZF-4722-2025
OI Bilgici, Birsen/0000-0001-7783-5039; GUMRUKCUOGLU, TANER
   ILKER/0000-0002-9453-602X
FU Ondokuz Mayis University, Turkey, Project Management Office
   [PYO.TIP.1901.15.016]
FX This study was supported by Ondokuz Mayis University, Turkey, Project
   Management Office (Project No: PYO.TIP.1901.15.016).
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   Stip E, 2012, TRANSL PSYCHIAT, V2, DOI 10.1038/tp.2012.53
   Stubbs B, 2016, PSYCHONEUROENDOCRINO, V63, P144, DOI 10.1016/j.psyneuen.2015.09.026
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NR 44
TC 0
Z9 0
U1 3
U2 15
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
EI 1873-3360
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD OCT
PY 2022
VL 144
AR 105862
DI 10.1016/j.psyneuen.2022.105862
EA JUL 2022
PG 6
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA 3F7ER
UT WOS:000830828400001
PM 35835020
DA 2025-06-11
ER

PT J
AU Munster-Segev, M
   Fuerst, O
   Kaplan, SA
   Cahn, A
AF Munster-Segev, Maya
   Fuerst, Oren
   Kaplan, Steven A.
   Cahn, Avivit
TI Incorporation of a Stress Reducing Mobile App in the Care of Patients
   With Type 2 Diabetes: A Prospective Study
SO JMIR MHEALTH AND UHEALTH
LA English
DT Article
DE diabetes mellitus; type 2; biofeedback; physiological stress response;
   mobile health; telemedicine
ID GLYCEMIC CONTROL
AB Background: Severe and sustained emotional stress creates a physiological burden through increased sympathetic activity and higher energy demand. This may lead to increased oxidative stress and development of the metabolic syndrome. Emotional stress has been shown to contribute to the onset, progression, and control of type 2 diabetes (T2D). Stress management and biofeedback assisted relaxation have been shown to improve glycemic control. Use of a mobile app for stress management may enhance the scalability of such an approach.
   Objective: The aim of this study was to assess the effect of using a mobile app of biofeedback-assisted relaxation on weight, blood pressure (BP), and glycemic measures of patients with T2D.
   Methods: Adult patients with T2D and inadequate glycemic control (hemoglobin A1c [HbA1c]>7.5%) were recruited from the outpatient diabetes clinic. Baseline weight, BP, HbA1c, fasting plasma glucose (FPG), triglycerides (TG), and 7-point self-monitoring of blood glucose were measured. Patients were provided with a stress reducing biofeedback mobile app and instructed to use it 3 times a day. The mobile app-Serenita-is an interactive relaxation app based on acquiring a photoplethysmography signal from the mobile phone's camera lens, where the user places his finger. The app collects information regarding the user's blood flow, heart rate, and heart rate variability and provides real-time feedback and individualized breathing instructions in order to modulate the stress level. All clinical and biochemical measures were repeated at 8 and 16 weeks of the study. The primary outcome was changes in measures at 8 weeks.
   Results: Seven patients completed 8 weeks of the study and 4 completed 16 weeks. At week 8, weight dropped by an average of 4.0 Kg (SD 4.3), systolic BP by 8.6 mmHg (SD 18.6), HbA1c by 1.3% (SD 1.6), FPG by 4.3 mmol/l (4.2), and serum TG were unchanged.
   Conclusions: Stress reduction using a mobile app based on biofeedback may improve glycemic control, weight, and BP.
C1 [Munster-Segev, Maya; Cahn, Avivit] Hadassah Hebrew Univ Hosp, Dept Internal Med, Diabet Unit, POB 12000, IL-91120 Jerusalem, Israel.
   [Fuerst, Oren] Ecofusion, Herzliyya, Israel.
   [Kaplan, Steven A.] Icahn Sch Med, New York, NY USA.
   [Kaplan, Steven A.] Mens Wellness Program Mt Sinai, New York, NY USA.
   [Cahn, Avivit] Hadassah Hebrew Univ Hosp, Dept Internal Med, Endocrinol & Metab Unit, Jerusalem, Israel.
C3 Hebrew University of Jerusalem; Hadassah University Hospital; Hadassah
   University Medical Center; Icahn School of Medicine at Mount Sinai;
   Hebrew University of Jerusalem; Hadassah University Hospital; Hadassah
   University Medical Center
RP Cahn, A (corresponding author), Hadassah Hebrew Univ Hosp, Dept Internal Med, Diabet Unit, POB 12000, IL-91120 Jerusalem, Israel.
EM avivit@hadassah.org.il
RI ; Cahn, Avivit/ABC-8272-2020
OI Fuerst, Oren/0000-0002-5076-2615; Munster Segev,
   Maya/0000-0002-3740-3327; Cahn, Avivit/0000-0002-7830-9994
CR American Diabetes Association, 2017, Diabetes Care, V40, pS33
   Gregoski MJ, 2012, INT J TELEMED APPL, V2012, DOI 10.1155/2012/696324
   Hegde SV, 2011, DIABETES CARE, V34, P2208, DOI 10.2337/dc10-2430
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NR 15
TC 20
Z9 20
U1 0
U2 23
PU JMIR PUBLICATIONS, INC
PI TORONTO
PA 130 QUEENS QUAY E, STE 1102, TORONTO, ON M5A 0P6, CANADA
SN 2291-5222
J9 JMIR MHEALTH UHEALTH
JI JMIR mHealth uHealth
PD MAY
PY 2017
VL 5
IS 5
AR e75
DI 10.2196/mhealth.7408
PG 7
WC Health Care Sciences & Services; Medical Informatics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Health Care Sciences & Services; Medical Informatics
GA EW2AG
UT WOS:000402297800005
PM 28554881
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Liu, ZY
   Yuan, JH
   Wen, P
   Guo, XF
   Wen, HC
   Guo, YJ
   Li, D
AF Liu, Zhiyuan
   Yuan, Jihong
   Wen, Ping
   Guo, Xiaofei
   Wen, Haichao
   Guo, Yanjun
   Li, Duo
TI Effect of lard plus soybean oil on blood pressure and other
   cardiometabolic risk factors in healthy subjects: a randomized
   controlled-feeding trial
SO FOOD & FUNCTION
LA English
DT Article
ID SKELETAL-MUSCLE CELLS; FATTY-ACID INTAKE; INSULIN-RESISTANCE;
   LINOLEIC-ACID; OLEIC-ACID; VITAMIN-D; INFLAMMATION; PALMITATE; STRESS;
   METAANALYSIS
AB Lard has been consumed by humans for thousands of years, but its consumption has declined substantially in the last few decades, because of negative publicity about the consumption of animal-derived saturated fats. Emerging evidence highlights that lard plus soybean oil (blend oil) could be more beneficial for body weight and liver function than the individual use of the two oils. This study aimed to evaluate the effects of blend oil on cardiometabolic risk factors in healthy subjects. This was a parallel, three-arm, randomized controlled-feeding trial. 334 healthy subjects (mean age: 33.1 years, 60% women) were randomized into three isoenergetic diet groups with three different edible oils (30 g day(-1)) (soybean oil, lard, and blend oil [50% lard and 50% soybean oil]) for 12 weeks. 245 (73.4%) participants completed the study. After the 12-week intervention, reductions in both systolic blood pressure (SBP) and diastolic blood pressure (DBP) were greater in the blend oil group than in the other two groups (P = 0.023 and 0.008 for the interaction between the diet group and time, respectively). Reductions of SBP and DBP in the blend oil group were more significant than those in the soybean oil group with P = 0.008 and P = 0.026 and the lard group with P < 0.001 and P < 0.001. Changes in SBP/DBP at 12 weeks were -6.0 (95% CI: -8.6 to -3.4)/0.8 (95% CI: -1.7 to 3.2) mmHg in the blend oil group, -3.3 (95% CI: -5.7 to -0.9)/1.5 (95% CI: -1.0 to 4.0) mmHg in the soybean oil group and -1.2 (95% CI: -3.7 to 1.4)/3.3 (95% CI: 0.9 to 5.8) mmHg in the lard group. Subgroup analyses showed that blend oil significantly decreased SBP and DBP compared with the other two groups in participants with BP & GE; 130/80 mmHg and body mass index & GE;25. There were no significant differences in the changes in body weight, waist circumference, serum lipids, or glucose between groups. In conclusion, our findings suggest that blend oil (lard plus soybean oil) reduces BP compared with soybean oil and lard in healthy subjects.
C1 [Liu, Zhiyuan; Guo, Xiaofei; Wen, Haichao; Guo, Yanjun; Li, Duo] Qingdao Univ, Inst Nutr & Hlth, Qingdao, Peoples R China.
   [Yuan, Jihong] Chinese Peoples Liberat Army Gen Hosp, Dept Nutr, Beijing, Peoples R China.
   [Wen, Ping] Chinese Peoples Liberat Army Gen Hosp, Supply Dept, Beijing, Peoples R China.
   [Li, Duo] Zhejiang Univ, Dept Food Sci & Nutr, Hangzhou, Peoples R China.
   [Li, Duo] Monash Univ, Dept Nutr Dietet & Food, Melbourne, Vic, Australia.
C3 Qingdao University; Chinese People's Liberation Army General Hospital;
   Chinese People's Liberation Army General Hospital; Zhejiang University;
   Monash University
RP Li, D (corresponding author), Qingdao Univ, Inst Nutr & Hlth, Qingdao, Peoples R China.; Li, D (corresponding author), Zhejiang Univ, Dept Food Sci & Nutr, Hangzhou, Peoples R China.; Li, D (corresponding author), Monash Univ, Dept Nutr Dietet & Food, Melbourne, Vic, Australia.
EM duoli@qdu.edu.cn
RI Wen, Haichao/JWA-3781-2024; Li, Duo/N-3682-2013
OI Li, Duo/0000-0001-5227-5565
FU National Natural Science Foundation of China [NSFC: 81773433]; Key
   Scientific Research Projects in Shandong Province China [2017YYSP007];
   Postdoctoral Science Foundation of Qingdao [RZ2100005769]
FX This work was supported by the National Natural Science Foundation of
   China (NSFC: 81773433), the Key Scientific Research Projects in Shandong
   Province China (2017YYSP007), and the Postdoctoral Science Foundation of
   Qingdao (RZ2100005769). We would like to thank all the participants, the
   investigators, on-site staff, and kitchen staff who contributed to this
   study. We also thank Miss Ruirui Liu for conducting erythrocyte membrane
   fatty acid composition analysis. We acknowledge Prof. Dongfeng Zhang and
   Mrs Xiaotong Kuang for their assistance in the statistical analysis.
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NR 76
TC 2
Z9 2
U1 2
U2 6
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PD JUL 31
PY 2023
VL 14
IS 15
BP 7117
EP 7129
DI 10.1039/d3fo01765f
EA JUN 2023
PG 13
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA N2VQ9
UT WOS:001027239100001
PM 37461334
DA 2025-06-11
ER

PT J
AU Lichtiger, A
   Fadaei, G
   Tagoe, CE
AF Lichtiger, Anna
   Fadaei, Golfam
   Tagoe, Clement E.
TI Autoimmune thyroid disease and rheumatoid arthritis: where the twain
   meet
SO CLINICAL RHEUMATOLOGY
LA English
DT Review
DE Autoimmune thyroid disease; Depression; Disease activity; Fibromyalgia;
   Osteoarthritis; Rheumatoid arthritis
ID NONSTEROIDAL ANTIINFLAMMATORY DRUGS; ANTITHYROID PEROXIDASE ANTIBODY;
   HASHIMOTOS-THYROIDITIS; CARDIOVASCULAR-DISEASE; SYNOVIAL FIBROBLASTS;
   RISK-FACTORS; PREVALENCE; ASSOCIATION; HYPOTHYROIDISM; POLYMORPHISM
AB Autoimmune thyroid disease (AITD) is the most prevalent autoimmune disease. It shares multiple genetic, clinical, and serologic characteristics with rheumatoid arthritis (RA). Although frequently described as a classic form of single-organ autoimmunity, the AITD disease burden in a subset of patients extends well beyond the thyroid gland. This review explores the complex interaction between the two diseases and the clinical consequences when they overlap. Beyond the well-known effects of AITD on thyroid function in RA, there is mounting evidence of the association of both conditions impacting the presentation and outcomes of diabetes, metabolic syndrome, and cardiovascular disease. An increasing number of studies suggest that there are negative effects of AITD on RA disease activity both in the presence and in the absence of thyroid dysfunction. Recent evidence suggests that AITD may not only worsen the cumulative damage of RA through higher disease activity but may also worsen secondary osteoarthritis changes. Less well-known is the significant association between AITD and chronic widespread pain syndromes including fibromyalgia. Importantly, the presence of fibromyalgia, which is increased in RA patients, appears to be further increased when it overlaps with AITD. Lastly, we probe the possible influence of AITD interacting with RA on fertility and clinical depression.Key Points center dot Autoimmune thyroid disease is the most common autoimmune disease and is frequently associated with rheumatoid arthritis.center dot Autoimmune thyroid disease can present with osteoarthritis, inflammatory arthritis, and chronic widespread pain syndromes.center dot The co-occurrence of autoimmune thyroid disease and rheumatoid arthritis may worsen disease activity and exacerbate other disease manifestations including cardiovascular disease, fertility, and depression.center dot The overlap of rheumatoid arthritis with autoimmune thyroid disease needs further research and should be sought in general clinical practice.
C1 [Lichtiger, Anna] Albert Einstein Coll Med, Dept Med, Bronx, NY USA.
   [Fadaei, Golfam] Griffin Hosp, Ansonia, CT USA.
   [Tagoe, Clement E.] Albert Einstein Coll Med, Dept Med, Div Rheumatol, Bronx, NY 10461 USA.
   [Tagoe, Clement E.] Montefiore Med Ctr, Div Gastroenterol, 111 East 210th St, Bronx, NY 10467 USA.
C3 Yeshiva University; Montefiore Medical Center; Albert Einstein College
   of Medicine; Yeshiva University; Montefiore Medical Center; Albert
   Einstein College of Medicine; Montefiore Medical Center; Albert Einstein
   College of Medicine
RP Tagoe, CE (corresponding author), Albert Einstein Coll Med, Dept Med, Div Rheumatol, Bronx, NY 10461 USA.; Tagoe, CE (corresponding author), Montefiore Med Ctr, Div Gastroenterol, 111 East 210th St, Bronx, NY 10467 USA.
EM alichtiger@montefiore.org; GFadaei@Griffinhealth.org; ctagoe@aol.com
OI Tagoe, Clement/0000-0003-4306-1340
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NR 102
TC 6
Z9 6
U1 0
U2 2
PU SPRINGER LONDON LTD
PI LONDON
PA 236 GRAYS INN RD, 6TH FLOOR, LONDON WC1X 8HL, ENGLAND
SN 0770-3198
EI 1434-9949
J9 CLIN RHEUMATOL
JI Clin. Rheumatol.
PD MAR
PY 2024
VL 43
IS 3
BP 895
EP 905
DI 10.1007/s10067-024-06888-6
EA FEB 2024
PG 11
WC Rheumatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Rheumatology
GA IX2E6
UT WOS:001159203200001
PM 38340224
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Legry, V
   Van Rooyent, DM
   Lambert, B
   Sempoux, C
   Poekes, L
   Español-Suñer, R
   Molendi-Coste, O
   Horsmans, Y
   Farrell, GC
   Leclercq, IA
AF Legry, Vanessa
   Van Rooyent, Derrick M.
   Lambert, Barbara
   Sempoux, Christine
   Poekes, Laurence
   Espanol-Suner, Regina
   Molendi-Coste, Olivier
   Horsmans, Yves
   Farrell, Geoffrey C.
   Leclercq, Isabelle A.
TI Endoplasmic reticulum stress does not contribute to steatohepatitis in
   obese and insulin-resistant high-fat-diet-fed foz/foz mice
SO CLINICAL SCIENCE
LA English
DT Article
DE apoptosis; endoplasmic reticulum stress; inflammation; insulin
   resistance; non-alcoholic fatty liver disease
ID UNFOLDED PROTEIN RESPONSE; LIVER-DISEASE; ER STRESS;
   GLUCOSE-HOMEOSTASIS; HEPATIC STEATOSIS; DIABETIC MICE; IN-VIVO; ACID;
   CHOP/GADD153; ACTIVATION
AB Non-alcoholic fatty liver (steatosis) and steatohepatitis [non-alcoholic steatohepatitis (NASH)] are hepatic complications of the metabolic syndrome. Endoplasmic reticulum (ER) stress is proposed as a crucial disease mechanism in obese and insulin-resistant animals (such as ob/ob mice) with simple steatosis, but its role in NASH remains controversial. We therefore evaluated the role of ER stress as a disease mechanism in foz/foz mice, which develop both the metabolic and histological features that mimic human NASH. We explored ER stress markers in the liver of foz/foz mice in response to a high-fat diet (HFD) at several time points. We then evaluated the effect of treatment with an ER stress inducer tunicamycin, or conversely with the ER protectant tauroursodeoxycholic acid (TUDCA), on the metabolic and hepatic features. foz/foz mice are obese, glucose intolerant and develop NASH characterized by steatosis, inflammation, ballooned hepatocytes and apoptosis from 6 weeks of HFD feeding. This was not associated with activation of the upstream unfolded protein response [phospho-eukaryotic initiation factor 2 alpha (eIF2 alpha), inositol-requiring enzyme 1 alpha (IRE1 alpha) activity and spliced X-box-binding protein 1 (Xbp1)]. Activation of c-Jun N-terminal kinase (JNK) and up-regulation of activating transcription factor-4 (Atf4) and CCAAT/enhancer-binding protein-homologous protein (Chop) transcripts were however compatible with a 'pathological' response to ER stress. We tested this by using intervention experiments. Induction of chronic ER stress failed to worsen obesity, glucose intolerance and NASH pathology in HFD-fed foz/foz mice. In addition, the ER protectant TUDCA, although reducing steatosis, failed to improve glucose intolerance, hepatic inflammation and apoptosis in HFD-fed foz/foz mice. These results show that signals driving hepatic inflammation, apoptosis and insulin resistance are independent of ER stress in obese diabetic mice with steatohepatitis.
C1 [Legry, Vanessa; Lambert, Barbara; Poekes, Laurence; Espanol-Suner, Regina; Molendi-Coste, Olivier; Horsmans, Yves; Leclercq, Isabelle A.] Catholic Univ Louvain, Inst Rech Expt & Clin, Lab Hepatogastroenterol, B-1200 Brussels, Belgium.
   [Van Rooyent, Derrick M.; Farrell, Geoffrey C.] Canberra Hosp, ANU Med Sch, Liver Res Grp, Garran, ACT, Australia.
   [Sempoux, Christine] Catholic Univ Louvain, St Luc Univ Hosp, Dept Pathol, B-1200 Brussels, Belgium.
C3 Universite Catholique Louvain; Australian National University; Canberra
   Hospital; Universite Catholique Louvain; Cliniques Universitaires
   Saint-Luc
RP Leclercq, IA (corresponding author), Catholic Univ Louvain, Inst Rech Expt & Clin, Lab Hepatogastroenterol, B-1200 Brussels, Belgium.
EM isabelle.leclercq@uclouvain.be
RI Molendi-Coste, Olivier/HKW-3196-2023
OI Molendi-Coste, Olivier/0000-0002-0498-9456; Sempoux,
   Christine/0000-0003-1375-3979; Poekes, Laurence/0000-0002-1892-0628
FU D.G. Higher Education and Scientific Research of the French Community of
   Belgium; Fund for Scientific Medical Research (Belgium); Australian
   National Health and Medical Research Council [418101]; AstraZeneca
   Belgium; Janssens Pharmaceutica Belgium; Roche Belgium
FX The work was supported by the D.G. Higher Education and Scientific
   Research of the French Community of Belgium, the Fund for Scientific
   Medical Research (Belgium), Australian National Health and Medical
   Research Council [grant number 418101] and unrestricted research grants
   from AstraZeneca Belgium, Janssens Pharmaceutica Belgium and Roche
   Belgium. I.A.L. is a FRS-FNRS research associate.
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NR 37
TC 20
Z9 22
U1 0
U2 21
PU PORTLAND PRESS LTD
PI LONDON
PA CHARLES DARWIN HOUSE, 12 ROGER STREET, LONDON WC1N 2JU, ENGLAND
SN 0143-5221
EI 1470-8736
J9 CLIN SCI
JI Clin. Sci.
PD OCT
PY 2014
VL 127
IS 7-8
BP 507
EP 518
DI 10.1042/CS20140026
PG 12
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA AQ1FD
UT WOS:000342526400008
PM 24766485
DA 2025-06-11
ER

PT J
AU Kibel, A
   Selthofer-Relatic, K
   Drenjancevic, I
   Bacun, T
   Bosnjak, I
   Kibel, D
   Gros, M
AF Kibel, Aleksandar
   Selthofer-Relatic, Kristina
   Drenjancevic, Ines
   Bacun, Tatjana
   Bosnjak, Ivica
   Kibel, Dijana
   Gros, Mario
TI Coronary microvascular dysfunction in diabetes mellitus
SO JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
LA English
DT Article
DE Diabetes mellitus; coronary microvascular dysfunction; microcirculation;
   endothelial dysfunction; cardiomyopathy; artery; nitric oxide;
   arachidonic acid metabolites
ID CARDIOVASCULAR MAGNETIC-RESONANCE; CONVERTING ENZYME-INHIBITION;
   ARACHIDONIC-ACID METABOLITES; L-ARGININE SUPPLEMENTATION;
   CALCIUM-CHANNEL BLOCKER; EXERCISE-INDUCED ANGINA; ST-SEGMENT DEPRESSION;
   CARDIAC SYNDROME-X; NF-KAPPA-B; ENDOTHELIAL DYSFUNCTION
AB The significance, mechanisms and consequences of coronary microvascular dysfunction associated with diabetes mellitus are topics into which we have insufficient insight at this time. It is widely recognized that endothelial dysfunction that is caused by diabetes in various vascular beds contributes to a wide range of complications and exerts unfavorable effects on microcirculatory regulation. The coronary microcirculation is precisely regulated through a number of interconnected physiological processes with the purpose of matching local blood flow to myocardial metabolic demands. Dysregulation of this network might contribute to varying degrees of pathological consequences. This review discusses the most important findings regarding coronary microvascular dysfunction in diabetes from pre-clinical and clinical perspectives.
C1 [Kibel, Aleksandar; Selthofer-Relatic, Kristina; Bosnjak, Ivica] Osijek Univ Hosp, Clin Internal Med, Dept Heart & Vasc Dis, Osijek, Croatia.
   [Kibel, Aleksandar; Drenjancevic, Ines; Kibel, Dijana; Gros, Mario] Univ Osijek, Fac Med, Dept Physiol & Immunol, Osijek, Croatia.
   [Selthofer-Relatic, Kristina; Bacun, Tatjana] Univ Osijek, Fac Med, Dept Internal Med, Osijek, Croatia.
   [Bacun, Tatjana] Osijek Univ Hosp, Clin Internal Med, Dept Endocrinol, Osijek, Croatia.
   [Kibel, Dijana; Gros, Mario] Osijek Univ Hosp, Dept Diagnost & Intervent Radiol, Osijek, Croatia.
C3 University of JJ Strossmayer Osijek; University of JJ Strossmayer Osijek
RP Kibel, A (corresponding author), Univ Osijek, Osijek Univ Hosp, Dept Heart & Vasc Dis, Clin Internal Med,Fac Med, J Huttlera 4, Osijek, Croatia.
EM aleksandar_mf@yahoo.com
RI Bosnjak, Ivica/KPA-7672-2024; Kibel, Aleksandar/H-6322-2019;
   Drenjancevic, Ines/AAZ-1038-2020
OI Drenjancevic, Ines/0000-0003-4964-7721
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TC 99
Z9 111
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PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0300-0605
EI 1473-2300
J9 J INT MED RES
JI J. Int. Med. Res.
PD DEC
PY 2017
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BP 1901
EP 1929
DI 10.1177/0300060516675504
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WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA FS5UA
UT WOS:000419863400027
PM 28643578
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Sicras-Mainar, A
   Rejas-Gutiérrez, J
   Navarro-Artieda, R
   Blanca-Tamayo, M
AF Sicras-Mainar, A.
   Rejas-Gutierrez, J.
   Navarro-Artieda, R.
   Blanca-Tamayo, M.
TI C-reactive protein as a marker of cardiovascular disease in patients
   with a schizophrenia spectrum disorder treated in routine medical
   practice
SO EUROPEAN PSYCHIATRY
LA English
DT Article
DE C-reactive protein; Schizophrenia spectrum disorders; Cardiovascular
   risk; Framingham function; Real world
ID CORONARY-HEART-DISEASE; METABOLIC SYNDROME; BIPOLAR DISORDER;
   RISK-FACTOR; PREVALENCE; INFLAMMATION; PREDICTION; ANTIPSYCHOTICS;
   OUTPATIENTS; POPULATION
AB Objective: Interest in cardiovascular diseases (CVD) in schizophrenia has grown recently due to documented incremental mortality. C-reactive protein (CRP) has been assessed as a marker in individuals with CVD and/or at high risk of developing it. However, its role in schizophrenia patients is unknown. The goal of this research was thus to explore the use of CRP as a marker of CVD risk in patients with schizophrenia.
   Methods: A cross-sectional analysis of the Badalona Serveis Assistencials (BSA) administrative claims database was conducted including all subjects aged > 18 years with a diagnosis of schizophrenia spectrum disorder. CRP measurement, sociodemographics, medical history, 10-year CVD risk (Framingham function) and clinical chemistry data were extracted for analysis. Results: Seven hundred and five patients (53.0% men, 48.2 [15.8] years, 78.7% on atypicals) met criteria for analysis. Mean 10-year CVD risk was high; 11.9 +/- 5.7% and mean CRP levels were 2.6 +/- 2.5 mg/L with 30.4% showing above-normative levels (> 3 mg/L). After adjusting for age, gender, smoking and presence of neoplasm or inflammatory diseases, CRP was linearly associated with 10-year CVD risk stratified by risk (low, moderate, high/very high): respectively, 2.3 (95% CI: 2.1-2.5), 3.1 (2.6-3.5) and 3.7 (3.2-4.1) mg/L; F = 13.5, P < 0.001. Patients with known CVD also showed higher CRP levels: 3.7 (2.9-4.5) vs. 2.5 (2.4-2.7) mg/L, P = 0.008; and higher probability of above-normal values; odds ratio = 4.71 (2.01-11.04), P < 0.001.
   Conclusions: High CRP levels above normative were associated with both known CVD and high/very high 10-year risk of a CVD event in patients with schizophrenia, suggesting CRP could be a marker of CVD in this psychiatric disorder. (C) 2011 Elsevier Masson SAS. All rights reserved.
C1 [Sicras-Mainar, A.] Badalona Serv Assistencials, Directorate Planning, Badalona, Barcelona, Spain.
   [Rejas-Gutierrez, J.] Pfizer Espana, Dept Hlth Outcomes Res, Corp Affairs & Market Access Unit, Alcobendas, Madrid, Spain.
   [Navarro-Artieda, R.] Hosp Badalona Germans Trias & Pujol, Dept Med Documentat, Badalona, Barcelona, Spain.
   [Blanca-Tamayo, M.] Badalona Serv Assistencials, Dept Psychiat, Badalona, Barcelona, Spain.
C3 Pfizer; Pfizer Spain; Hospital Germans Trias i Pujol
RP Sicras-Mainar, A (corresponding author), Badalona Serv Assistencials, Directorate Planning, Badalona, Barcelona, Spain.
EM asicras@bsa.cat
FU Pfizer Spain
FX Antoni Sicras and Milagrosa Blanca are employees of BSA, the health
   provider which owned the database which was the subject of this study.
   Javier Rejas is an employee of Pfizer Spain SL. Editorial support was
   funded by Pfizer Spain. The role of editorial support was in charge of
   preparing the manuscript for an English journal, along with support in
   translation, editing of typos and style of writing, and also in the
   preparation of submission. An abstract with preliminary data was
   presented during the year 2010 annual meeting of the ISPOR Society.
   Poster preparation and presentation was also funded by Pfizer Spain.
   There was no other financial support for this work.
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PD MAR
PY 2013
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UT WOS:000316737800004
PM 21964485
DA 2025-06-11
ER

PT J
AU Altiparmak, IH
   Erkus, ME
   Sezen, H
   Demirbag, R
   Kaya, Z
   Sezen, Y
   Gunebakmaz, O
   Asoglu, R
   Besli, F
   Neselioglu, S
   Erel, O
AF Altiparmak, Ibrahim H.
   Erkus, Muslihittin E.
   Sezen, Hatice
   Demirbag, Recep
   Kaya, Zekeriya
   Sezen, Yusuf
   Gunebakmaz, Ozgur
   Asoglu, Ramazan
   Besli, Feyzullah
   Neselioglu, Salim
   Erel, Ozcan
TI Evaluation of thiol levels, thiol/disulfide homeostasis and their
   relation with inflammation in cardiac syndrome X
SO CORONARY ARTERY DISEASE
LA English
DT Article
DE cardiac syndrome X; microvascular angina; antioxidants; thiol;
   thiol/disulfide homeostasis; inflammation
ID OXIDATIVE STRESS; CARDIOVASCULAR-DISEASE; ANTIOXIDANT CAPACITY;
   ASSOCIATION; DYSFUNCTION; MARKERS; PROTEIN; ACID
AB Objectives Cardiac syndrome X (CSX) is characterized by the presence of myocardial ischemia in the absence of coronary artery stenosis on angiograms. Its relation to oxidative stress and inflammation is well known. There are no data on thiols and their relation with inflammation in CSX. The aim of this study was to investigate thiol levels and thiol/disulfide homeostasis in CSX patients.
   Materials and methods Fifty consecutive patients who had documented myocardial ischemia and normal coronary angiogram (CSX group), and 45 age-matched and sex-matched consecutive patients who had normal coronary angiogram without myocardial ischemia (control group) were enrolled in this study. C-reactive protein (CRP), neutrophil/lymphocyte ratio (NLR), native thiol, total thiol, and disulfide levels were measured and disulfide/thiol ratios were calculated in all patients.
   Results Demographic, clinical, basic laboratory, and echocardiographic characteristics were similar in the two groups (P>0.05). Serum total thiol, native thiol, and disulfide levels decreased significantly in the CSX group compared with the control group (P<0.001). CRP and NLR increased significantly in the CSX group compared with the control group (P<0.001). Although disulfide/native thiol levels increased in the CSX group, this reduction did not reach statistical significance (5.8 vs. 5.5, P>0.05). The reduction of thiols was correlated negatively with CRP and NLR (P<0.001). Although univariate logistic regression analyses showed that serum total and native thiol levels, CRP and NLR were independent predictors for CSX estimation, stepwise multivariate logistic regression analysis showed only total thiol levels as an independent predictor for CSX (odds ratio=0.966, 95% confidence interval: 0.950-0.982, P<0.001). Also, receiver operating characteristic curve analysis showed that serum total thiol values of 338.4 or below could predict the CSX with 86% sensitivity and 84% specificity (area under curve = 0.903; 95% confidence interval: 0.842-0.965).
   Conclusion Serum total thiol levels decreased significantly in CSX and this reduction independently predicted CSX with strong sensitivity and specificity. This suggests that the reduction in thiols along with increased inflammation may play a pathophysiological role in the development of CSX. Copyright (C) 2016 Wolters Kluwer Health, Inc. All rights reserved.
C1 [Altiparmak, Ibrahim H.; Erkus, Muslihittin E.; Demirbag, Recep; Kaya, Zekeriya; Sezen, Yusuf; Gunebakmaz, Ozgur] Harran Univ, Fac Med, Dept Cardiol, TR-63100 Sanliurfa, Turkey.
   [Sezen, Hatice] Harran Univ, Fac Med, Dept Biochem, Sanliurfa, Turkey.
   [Besli, Feyzullah] Mehmet Akif Inan Training & Res Hosp, Dept Cardiol, Sanliurfa, Turkey.
   [Asoglu, Ramazan] Mus State Hosp, Cardiol Clin, Mus, Turkey.
   [Neselioglu, Salim; Erel, Ozcan] Yildirim Beyazit Univ, Fac Med, Dept Biochem, Ankara, Turkey.
C3 Harran University; Harran University; Sanliurfa Mehmet Akif Inan
   Training & Research Hospital; Mus State Hospital; Ankara Yildirim
   Beyazit University
RP Altiparmak, IH (corresponding author), Harran Univ, Fac Med, Dept Cardiol, TR-63100 Sanliurfa, Turkey.
EM ihaltiparmak@gmail.com
RI EREL, Ozcan/U-1008-2019; Demirbag, Recep/Z-2369-2019; altıparmak,
   ibrahim/ABF-4178-2020; asoglu, ramazan/AAB-2779-2019; neselioglu,
   salim/F-6853-2013; Erkuş, Emre/ABC-4126-2021
OI Demirbag, Recep/0000-0001-7831-2715; neselioglu,
   salim/0000-0002-0974-5717
CR Ates I, 2016, ENDOCRINE, V51, P47, DOI 10.1007/s12020-015-0784-6
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NR 28
TC 24
Z9 25
U1 0
U2 12
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0954-6928
EI 1473-5830
J9 CORONARY ARTERY DIS
JI Coronary Artery Dis.
PD JUN
PY 2016
VL 27
IS 4
BP 295
EP 301
DI 10.1097/MCA.0000000000000362
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA DK7QV
UT WOS:000375121700008
PM 26928883
DA 2025-06-11
ER

PT J
AU Araki, S
   Dobashi, K
   Yamamoto, Y
   Asayama, K
   Kusuhara, K
AF Araki, Shunsuke
   Dobashi, Kazushige
   Yamamoto, Yukiyo
   Asayama, Kohtaro
   Kusuhara, Koichi
TI Increased plasma isoprostane is associated with visceral fat, high
   molecular weight adiponectin, and metabolic complications in obese
   children
SO EUROPEAN JOURNAL OF PEDIATRICS
LA English
DT Article
DE Oxidative stress; 8-epi-prostanglandin-F-2 alpha; Adiponectin; Visceral
   adipose tissue; Metabolic syndrome; Insulin resistance; Children and
   adolescents
ID INCREASED OXIDATIVE STRESS; INTIMA-MEDIA THICKNESS; INSULIN-RESISTANCE;
   LIPID-PEROXIDATION; ADIPOSE; ACCUMULATION; INFLAMMATION; MARKERS;
   DYSFUNCTION; EXPRESSION
AB Oxidative stress is considered to be increased in obese subjects. However, the association of oxidative stress with visceral adiposity and adiponectin level is not fully understood in children. Forty-four obese Japanese children and adolescents, 28 boys and 16 girls, with median age of 9.9 years [5.2-13.8 years], and the 28 age-matched non-obese healthy controls, 15 boys and 13 girls, were enrolled in this study. The median BMI Z scores were +2.21 [1.31-4.38] for the obese subjects and -0.72 [-2.11-1.31] for the control. Plasma concentrations of 8-epi-prostaglandin F-2 alpha (isoprostane), a marker of oxidative stress, and adiponectin fractions were assayed using ELISA. 8-epi-PGF(2 alpha) levels were significantly higher in the obese group (37.1 [4.7-112.7], median and the range) than in the control (11.5 [4.5-27.3]). In a univariate analysis, concentrations of 8-epi-PGF(2 alpha) positively correlated with visceral adipose tissue area measured by computed tomography, waist circumference, serum triglycerides, alanine aminotransferase, insulin levels, and the homeostasis of minimal assessment of insulin resistance and inversely correlated with high-density-lipoprotein cholesterol and high-molecular weight (HMW) adiponectin. Total-, medium-, or low-molecular weight adiponectin fraction did not show a significant correlation with 8-epi-PGF(2 alpha). Forty of 44 obese children had one or more metabolic complications. The 8-epi-PGF(2 alpha) levels also elevated with increasing numbers of obesity-related complications. These results suggest that oxidative stress is enhanced in relation to visceral fat accumulation and decreasing HMW adiponectin level in childhood obesity. Oxidative stress may be associated with the development of obesity-related complications.
C1 [Araki, Shunsuke; Yamamoto, Yukiyo; Kusuhara, Koichi] Univ Occupat & Environm Hlth, Sch Med, Dept Pediat, Yahatanishi Ku, Kitakyushu, Fukuoka 8078555, Japan.
   [Dobashi, Kazushige] Showa Univ, Dept Pediat, Sch Med, Shinagawa Ku, Tokyo 1428666, Japan.
   [Asayama, Kohtaro] TOKYO KASEI GAKUIN Univ, Fac Hlth Nutr, Tokyo 1940292, Japan.
C3 University of Occupational & Environmental Health - Japan; Showa
   University
RP Araki, S (corresponding author), Univ Occupat & Environm Hlth, Sch Med, Dept Pediat, Yahatanishi Ku, 1-1 Iseigaoka, Kitakyushu, Fukuoka 8078555, Japan.
EM arashun@med.uoeh-u.ac.jp
FU Ministry of Education, Culture, Sports, Science and Technology, Japan
   [21591340, 18591173]; Grants-in-Aid for Scientific Research [18591173,
   21591340] Funding Source: KAKEN
FX The authors thank Miss Yuki Ohga for her technical assistance. This work
   was supported in part by a Grant-in-Aid for Scientific Research
   #21591340 and #18591173 from the Ministry of Education, Culture, Sports,
   Science and Technology, Japan.
CR Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
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NR 33
TC 43
Z9 46
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0340-6199
EI 1432-1076
J9 EUR J PEDIATR
JI Eur. J. Pediatr.
PD AUG
PY 2010
VL 169
IS 8
BP 965
EP 970
DI 10.1007/s00431-010-1157-z
PG 6
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA 614SU
UT WOS:000279080800009
PM 20169448
DA 2025-06-11
ER

PT J
AU Yida, Z
   Imam, MU
   Ismail, M
   Ismail, N
   Ideris, A
   Abdullah, MA
AF Yida, Zhang
   Imam, Mustapha Umar
   Ismail, Maznah
   Ismail, Norsharina
   Ideris, Aini
   Abdullah, Maizaton Atmadini
TI High fat diet-induced inflammation and oxidative stress are attenuated
   by N-acetylneuraminic acid in rats
SO JOURNAL OF BIOMEDICAL SCIENCE
LA English
DT Article
DE High fat diet; Inflammation; Oxidative stress; N-acetylneuraminic acid;
   Sialic acid
ID SERUM SIALIC-ACID; METABOLIC SYNDROME; CARDIOVASCULAR-DISEASE; INSULIN
   SENSITIVITY; ATHEROSCLEROSIS; ADIPONECTIN; OBESITY
AB Background: Serum sialic acid levels are positively correlated with coronary artery disease and inflammation. Although sialic acid is a non-specific marker, it is considered sensitive likely due to its influence in sialylation of glycoprotein structures all over the body.
   Objectives: We hypothesized that dietary supplementation with N-acetylneuraminic acid (Neu5Ac), a type of sialic acid, will have profound effects on high fat diet-(HFD-) induced inflammation and oxidative stress in view of the widespread incorporation of sialic acid into glycoprotein structures in the body.
   Methods: HFD-fed rats with or without simvastatin or Neu5Ac (50 and 400 mg/kg/day) were followed up for 12 weeks. Lipid profiles, and markers of inflammation (C-reactive protein, interleukin-6, and tumor necrosis factor alpha), insulin resistance (serum insulin and adiponectin, oral glucose tolerance test and homeostatic model of insulin resistance) and oxidative stress (total antioxidant status and thiobarbituric acid reactive species) in the serum and liver were determined, while mRNA levels of hepatic antioxidant and inflammation genes were also quantified. Serum levels of alanine transaminase, aspartate transaminase, alkaline phosphatase, urea, creatinine and uric acid were also assessed.
   Results: HFD feeding caused hyperlipidemia and insulin resistance, and worsened liver and kidney functions. HFD feeding also potentiated inflammation and oxidative stress, partly through modulation of hepatic gene expression, while Neu5Ac especially at higher doses and simvastatin attenuated HFD-induced changes, although Neu5Ac showed better outcomes.
   Conclusions: Based on the present results, we surmised that Neu5Ac can prevent HFD-induced inflammation and oxidative stress, and may in fact be useful in the prevention of hyperlipidemia-associated inflammation and oxidative stress. However, the translational implications of these findings can only be determined after long-term effects are established. Hence, the use of Neu5Ac on obesity-related diseases requires additional attention.
C1 [Yida, Zhang; Imam, Mustapha Umar; Ismail, Maznah; Ismail, Norsharina; Ideris, Aini; Abdullah, Maizaton Atmadini] Univ Putra Malaysia, Inst Biosci, Lab Mol Biomed, Serdang 43400, Selangor, Malaysia.
   [Yida, Zhang] Chengde Med Univ, Affiliated Hosp, Dept Cardiol, Chengde 067000, Hebei, Peoples R China.
   [Ismail, Maznah] Univ Putra Malaysia, Fac Med & Hlth Sci, Dept Nutr & Dietet, Serdang 43400, Selangor, Malaysia.
   [Ideris, Aini] Univ Putra Malaysia, Fac Vet Med, Serdang 43400, Selangor, Malaysia.
   [Abdullah, Maizaton Atmadini] Univ Putra Malaysia, Fac Med & Hlth Sci, Dept Pathol, Upm Serdang 43400, Selangor, Malaysia.
C3 Universiti Putra Malaysia; Chengde Medical University; Universiti Putra
   Malaysia; Universiti Putra Malaysia; Universiti Putra Malaysia
RP Imam, MU (corresponding author), Univ Putra Malaysia, Inst Biosci, Lab Mol Biomed, Serdang 43400, Selangor, Malaysia.
EM mustyimam@gmail.com; myhome.e@gmail.com
RI Imam, Mustapha/K-3490-2012
OI Abdullah, Maizaton Atmadini/0000-0002-1614-7125; Imam, Mustapha
   Umar/0000-0001-9888-4809; ISMAIL, MAZNAH/0000-0002-2378-0519; Ideris,
   Aini/0000-0001-8640-517X; Ismail, Norsharina/0000-0002-2580-8300
FU Ministry of Science, Technology and Innovation (MOSTI), Malaysia
   [02-01-04-SF1453]
FX The authors thank the Ministry of Science, Technology and Innovation
   (MOSTI), Malaysia for sponsoring this research (e-Sciencefund
   02-01-04-SF1453). The authors also thank the staff of the Laboratory of
   Molecular Biomedicine for their assistance during the study.
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NR 30
TC 61
Z9 69
U1 0
U2 35
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1021-7770
EI 1423-0127
J9 J BIOMED SCI
JI J. Biomed. Sci.
PD OCT 24
PY 2015
VL 22
AR 96
DI 10.1186/s12929-015-0211-6
PG 10
WC Cell Biology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Research & Experimental Medicine
GA CU6IA
UT WOS:000363634300001
PM 26498218
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Zhou, M
   Lv, JY
   Chen, XL
   Shi, YJ
   Chao, GQ
   Zhang, S
AF Zhou, Mi
   Lv, Jianyu
   Chen, Xinli
   Shi, Yujie
   Chao, Guanqun
   Zhang, Shuo
TI From gut to liver: Exploring the crosstalk between gut-liver axis and
   oxidative stress in metabolic dysfunction-associated steatotic liver
   disease
SO ANNALS OF HEPATOLOGY
LA English
DT Article
DE Metabolic dysfunction-associated steatotic; liver disease; Gut-liver
   axis; Oxidative stress; Bile acids; Gut microbiota
AB Non-alcoholic fatty liver disease (NAFLD), now recognized as metabolic dysfunction-associated steatotic liver disease (MASLD), represents a significant and escalating global health challenge. Its prevalence is intricately linked to obesity, insulin resistance, and other components of the metabolic syndrome. As our comprehension of MASLD deepens, it has become evident that this condition extends beyond the liver, embodying a complex, multi-systemic disease with hepatic manifestations that mirror the broader metabolic landscape. This comprehensive review delves into the critical interplay between the gut-liver axis and oxidative stress, elucidating their pivotal roles in the etiology and progression of MASLD. Our analysis reveals several key findings: (1) Bile acid dysregulation can trigger oxidative stress through enhanced ROS production in hepatocytes and Kupffer cells, leading to mitochondrial dysfunction and lipid peroxidation; (2) Gut microbiota dysbiosis disrupts intestinal barrier function, allowing increased translocation of endotoxins like LPS, which activate inflammatory pathways through TLR4 signaling and promote oxidative stress via NADPH oxidase activation; (3) The redox-sensitive transcription factors NF-KB and Nrf2 serve as crucial mediators in the gutliver axis, with NF-KB regulating inflammatory responses and Nrf2 orchestrating antioxidant defenses; (4) Oxidative stress-induced damage to intestinal barrier function creates a destructive feedback loop, further exacerbating liver inflammation and disease progression. These findings highlight the complex interrelationship between gut-liver axis dysfunction and oxidative stress in MASLD pathogenesis, suggesting potential therapeutic targets for disease management. (c) 2025 Fundaci & oacute;n Cl & iacute;nica M & eacute;dica Sur, A.C. Published by Elsevier Espa & ntilde;a, S.L.U. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
C1 [Zhou, Mi; Lv, Jianyu; Chen, Xinli; Shi, Yujie; Zhang, Shuo] Zhejiang Chinese Med Univ, Dept Gastroenterol, Xinhua Hosp Zhejiang Prov, Affiliated Hosp 2, Hangzhou, Zhejiang, Peoples R China.
   [Chao, Guanqun] Zhejiang Univ, Sch Med, Sir Run Run Shaw Hosp, Dept Gen Practice, Hangzhou, Peoples R China.
C3 Zhejiang Chinese Medical University; Zhejiang University
RP Zhang, S (corresponding author), Zhejiang Chinese Med Univ, Dept Gastroenterol, Xinhua Hosp Zhejiang Prov, Affiliated Hosp 2, Hangzhou, Zhejiang, Peoples R China.
EM zhangshuotcm@126.com
RI lv, jianyu/HKN-7302-2023
FU National Natural Science Foundation of China [81973598]; Chinese
   Medicine Clinical Research Program [2024ZL103, 202371061]; Research Fund
   of National Health Commission [WKJ-ZJ-2435]; Zhejiang Provincial
   Traditional Chinese Medicine Science and Technology Program Young Talent
   Project [2021ZQ086]
FX This research was supported by the National Natural Science Foundation
   of China (NO.81973598) , the Chinese Medicine Clinical Research Program
   (NO.2024ZL103, NO.202371061) , the Research Fund of National Health
   Commission (NO.WKJ-ZJ-2435) , and the Zhejiang Provincial Traditional
   Chinese Medicine Science and Technology Program Young Talent Project
   (NO. 2021ZQ086) .
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NR 71
TC 4
Z9 4
U1 9
U2 9
PU ELSEVIER ESPANA
PI MADRID
PA CALLE DE ZURBANO, 76-4TH FLR LEFT, MADRID, 28010, SPAIN
SN 1665-2681
J9 ANN HEPATOL
JI Ann. Hepatol.
PD JAN-JUN
PY 2025
VL 30
IS 1
AR 101777
DI 10.1016/j.aohep.2025.101777
EA JAN 2025
PG 7
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA U6W5V
UT WOS:001413173700001
PM 39832564
OA gold
DA 2025-06-11
ER

PT J
AU Muhammad, AB
   Lokhandwala, MF
   Banday, AA
AF Muhammad, Abdul Bari
   Lokhandwala, Mustafa F.
   Banday, Anees A.
TI Exercise reduces oxidative stress but does not alleviate
   hyperinsulinemia or renal dopamine D1 receptor dysfunction in
   obese rats
SO AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
LA English
DT Article
DE reactive oxygen species; insulin sensitivity; natriuresis; nuclear
   factor-kappa B; hypertension
ID HIGH-DENSITY-LIPOPROTEIN; IMPROVES INSULIN SENSITIVITY; FACTOR-KAPPA-B;
   PROXIMAL TUBULES; OXIDIZED-LDL; DIABETIC-NEPHROPATHY; BODY-WEIGHT;
   ZUCKER RATS; INHIBITS 3; IN-VIVO
AB Muhammad AB, Lokhandwala MF, Banday AA. Exercise reduces oxidative stress but does not alleviate hyperinsulinemia or renal dopamine D-1 receptor dysfunction in obese rats. Am J Physiol Renal Physiol 300: F98-F104, 2011. First published October 6, 2010; doi:10.1152/ajprenal.00386.2010.-Impairment of renal dopamine D-1 receptor (D1R)-mediated natriuresis is associated with hypertension in humans and animal models, including obese Zucker rats. We have previously reported that treatment of these rats with antioxidants or insulin sensitizers reduced insulin levels and oxidative stress, restored D1R-mediated natriuresis, and reduced blood pressure. Furthermore, the redox-sensitive transcription factor, nuclear factor-kappa B (NF-kappa B), has been implicated in impairment of D1R-mediated natriuresis during oxidative stress. In this study, we investigated the effect of exercise on insulin levels, oxidative stress, nuclear translocation of NF-kappa B, blood pressure, albuminuria, and D1R-mediated natriuresis. The exercise protocol involved treadmill exercise from 3 wk of age for 8 wk. Exercise reduced oxidative stress, nuclear translocation of NF-kappa B, and albuminuria. However, exercise did not reduce plasma insulin levels or blood pressure. Also, selective D1R agonist (SKF-38393)mediated increases in sodium excretion and guanosine 5'-O-(3-thio-triphosphate) binding were impaired in obese rats compared with lean rats, and exercise did not restore this defect. We conclude that, while exercise is beneficial in reducing oxidative stress and renal injury, reducing insulin levels may be required to restore D1R-mediated natriuresis in this model of obesity and metabolic syndrome. Furthermore, this study supports previous observations that restoring D1R function contributes to blood pressure reduction in this model.
C1 [Muhammad, Abdul Bari; Lokhandwala, Mustafa F.; Banday, Anees A.] Univ Houston, Coll Pharm, Heart & Kidney Inst, Houston, TX 77204 USA.
C3 University of Houston System; University of Houston
RP Banday, AA (corresponding author), Univ Houston, Coll Pharm, Heart & Kidney Inst, S & R-2 Bldg,4800 Calhoun Rd, Houston, TX 77204 USA.
EM abanday@uh.edu
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NR 74
TC 15
Z9 19
U1 0
U2 4
PU AMER PHYSIOLOGICAL SOC
PI Rockville
PA 6120 Executive Blvd, Suite 600, Rockville, MD, UNITED STATES
SN 1931-857X
EI 1522-1466
J9 AM J PHYSIOL-RENAL
JI Am. J. Physiol.-Renal Physiol.
PD JAN
PY 2011
VL 300
IS 1
BP F98
EP F104
DI 10.1152/ajprenal.00386.2010
PG 7
WC Physiology; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology; Urology & Nephrology
GA 703FP
UT WOS:000285964000012
PM 20926629
DA 2025-06-11
ER

PT J
AU Lu, YX
   Qian, L
   Zhang, Q
   Chen, B
   Gui, L
   Huang, DK
   Chen, GJ
   Chen, L
AF Lu, Yunxia
   Qian, Lei
   Zhang, Qiu
   Chen, Bing
   Gui, Li
   Huang, Dake
   Chen, Guanjun
   Chen, Li
TI Palmitate induces apoptosis in mouse aortic endothelial cells and
   endothelial dysfunction in mice fed high-calorie and high-cholesterol
   diets
SO LIFE SCIENCES
LA English
DT Article
DE High-calorie and high-cholesterol diets; Palmitate; Mouse aortic
   endothelial cell; Endoplasmic reticulum stress; Oxidative stress
ID ENDOPLASMIC-RETICULUM; INSULIN-RESISTANCE; OXIDATIVE STRESS; METABOLIC
   SYNDROME; INDUCED OBESITY; INFLAMMATION; ADIPOKINES; DAMAGE; DEATH;
   LIVER
AB Aims: Obesity is associated with hypertriglyceridemia and elevated circulating free fatty acids (FFA), resulting in endothelial dysfunction. Endoplasmic reticulum (ER) stress has been implicated in many of these processes. To determine if ER stress participates in palmitate-induced apoptosis, we investigated the effects of diet-induced obesity and palmitate on mouse aortic endothelial cells (MAEC) in vivo and in vitro.
   Main methods: Male C57BL/6 mice were fed standard chow diets (SCD) or high-calorie and high-cholesterol diets (HCD) for 3 months. Insulin resistance was detected, and the serum, including proinflammatory indices and markers of endothelial function, was also analyzed. The ultrastructure and apoptosis of the endothelial cells in the thoracic aorta were observed. The primary MAEC were separated and treated with palmitate at different concentrations or different times respectively to observe any changes in cellular proliferation, intracellular reactive oxygen species (ROS) levels and apoptosis. Finally, the ER stress markers C/EBP homologous protein (CHOP) and glucose-regulated protein 78 (GRP78) were analyzed.
   Key findings: HCD-fed obese mice became inflammation-activated and insulin-resistant Swollen mitochondria, expanded ER and apoptosis in the endothelial cells of the thoracic aorta were observed in HCD-fed mice. Palmitate inhibited cell proliferation, increased production of ROS and induced apoptosis in MAEC. CHOP was overexpressed and shifted into the nucleus (mainly), while the expression of GRP78 was upregulated in the palmitate-treated MAEC.
   Significance: Our results indicate that diet-induced obesity results in endothelial dysfunction in vivo, and that oxidative and ER stress may be involved in apoptosis induced by the palmitate in vitro. (C) 2013 Elsevier Inc. All rights reserved.
C1 [Lu, Yunxia; Qian, Lei; Chen, Bing; Chen, Guanjun; Chen, Li] Anhui Med Univ, Dept Biochem & Mol Biol, Hefei 230032, Anhui, Peoples R China.
   [Lu, Yunxia; Gui, Li; Huang, Dake] Anhui Med Univ, Comprehens Lab, Hefei 230032, Anhui, Peoples R China.
   [Qian, Lei] Anhui Med Univ, Dept Pharm, Affiliated Hosp 1, Hefei 230022, Anhui, Peoples R China.
   [Zhang, Qiu] Anhui Med Univ, Dept Endocrinol, Affiliated Hosp 1, Hefei 230022, Anhui, Peoples R China.
C3 Anhui Medical University; Anhui Medical University; Anhui Medical
   University; Anhui Medical University
EM wwwdluyx@sina.com
RI Guanjun, Chen/AAN-1550-2021; Lu, Yunxia/AAU-6408-2021; gui,
   li/GQQ-2739-2022
FU Anhui Medical University [XJ201013]; Anhui Natural Science Foundation of
   China [1208085MH168]
FX This study was supported by Grants for Scientific Research of BSKY
   (XJ201013) from Anhui Medical University and grants of the Fund of Anhui
   Natural Science Foundation of China (1208085MH168).
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NR 33
TC 49
Z9 57
U1 0
U2 17
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0024-3205
EI 1879-0631
J9 LIFE SCI
JI Life Sci.
PD JUL 10
PY 2013
VL 92
IS 24-26
BP 1165
EP 1173
DI 10.1016/j.lfs.2013.05.002
PG 9
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA 173IK
UT WOS:000321072400003
PM 23680379
DA 2025-06-11
ER

PT J
AU Sarkhosh-Khorasani, S
   Sangsefidi, ZS
   Hosseinzadeh, M
AF Sarkhosh-Khorasani, Sahar
   Sangsefidi, Zohreh Sadat
   Hosseinzadeh, Mahdieh
TI The effect of grape products containing polyphenols on oxidative stress:
   a systematic review and meta-analysis of randomized clinical trials
SO NUTRITION JOURNAL
LA English
DT Review
DE Grape; Polyphenols; oxidative stress; meta-analysis
ID LOW-DENSITY-LIPOPROTEIN; RED WINE CONSUMPTION; TOTAL ANTIOXIDANT
   CAPACITY; DOUBLE-BLIND; METABOLIC SYNDROME; SEED EXTRACT; CARDIOVASCULAR
   RISK; ALCOHOL-CONSUMPTION; VITIS-VINIFERA; RESVERATROL SUPPLEMENTATION
AB BackgroundThe literature showed that Grape Products Containing Polyphenols (GPCP) had anti-oxidant activity. However, the effects of GPCP on different biomarkers of oxidative stress are still controversial. In this regard, this systematic review and meta-analysis aimed to evaluate the effect of Grape Products Containing Polyphenols (GPCP) intake on oxidative stress markers.MethodsPubMed, Scopus, Web of Science, and Google Scholar data bases were searched up to August 20, 2020. A random-effects model, weighted mean difference (WMD), and 95% confidence interval (CI) were applied for data analysis. Meta-analysis was conducted over 17 eligible RCTs with a total of 633 participants. The study registration number is CRD42019116696.ResultsA significant increase was observed in Total Antioxidant Capacity (TAC) (weighted mean difference (WMD)=1.524mmol/L, 95% confidence interval (CI): 0.83, 2.21). Intake of GPCP enhanced Superoxide Dismutase (SOD) (WMD=0.450mmol/L, 95% CI: 0.23, 0.66), TAC (WMD=2.829mmol/L, 95% CI: 0.13, 5.52), and Oxygen Radical Absorbance Capacity (ORAC) (WMD=0.524 mu mol/L, 95% CI: 0.42, 0.62) among healthy participants. Higher GPCP doses increased SOD (WMD=0.539U/mgHb, 95% CI: 0.24, 0.82) and ORAC (WMD=0.377 mu mol/L, 95% CI: 0.08, 0.67), whereas longer intervention periods enhanced ORAC (WMD=0.543 mu mol/L, 95% CI: 0.43, 0.64).ConclusionGPCP intake may partly improve status of oxidative stress, but further well-designed trials are required to confirm these results.
C1 [Sarkhosh-Khorasani, Sahar; Sangsefidi, Zohreh Sadat; Hosseinzadeh, Mahdieh] Shahid Sadoughi Univ Med Sci, Nutr & Food Secur Res Ctr, Yazd, Iran.
   [Sarkhosh-Khorasani, Sahar; Sangsefidi, Zohreh Sadat; Hosseinzadeh, Mahdieh] Shahid Sadoughi Univ Med Sci, Sch Publ Hlth, Dept Nutr, Yazd, Iran.
C3 Shahid Sadoughi University of Medical Sciences; Shahid Sadoughi
   University of Medical Sciences
RP Hosseinzadeh, M (corresponding author), Shahid Sadoughi Univ Med Sci, Nutr & Food Secur Res Ctr, Yazd, Iran.; Hosseinzadeh, M (corresponding author), Shahid Sadoughi Univ Med Sci, Sch Publ Hlth, Dept Nutr, Yazd, Iran.
EM hoseinzade.mahdie@gmail.com
RI Sangsefidi, Zohreh Sadat/AAZ-7335-2021
FU Nutrition and Food Security research center, Shahid Sadoughi University
   of Medical Sciences, Yazd, Iran
FX This research was funded by Nutrition and Food Security research center,
   Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
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NR 145
TC 14
Z9 16
U1 2
U2 14
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1475-2891
J9 NUTR J
JI Nutr. J.
PD MAR 12
PY 2021
VL 20
IS 1
AR 25
DI 10.1186/s12937-021-00686-5
PG 18
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA QW8DB
UT WOS:000628877100002
PM 33712024
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Reza-Zaldívar, EE
   Bojorquez-Rodríguez, EM
   Jacobo-Velázquez, DA
AF Reza-Zaldivar, Edwin E.
   Bojorquez-Rodriguez, Erika Melissa
   Jacobo-Velazquez, Daniel A.
TI Wounding stress enhances the anti-obesogenic, anti-inflammatory, and
   antioxidant properties of carrots (Daucus carota)
SO JOURNAL OF AGRICULTURE AND FOOD RESEARCH
LA English
DT Article
DE Wounding stress; Anti-obesogenic properties; Chlorogenic acid;
   Anti-inflammatory activity; Stressed carrots
ID ACTIVITY CAA ASSAY; CHLOROGENIC ACID; PHENOLIC ANTIOXIDANTS;
   NITRIC-OXIDE; BROWN-FAT; LIPOLYSIS; NITRATE; WHITE; BIOSYNTHESIS;
   INHIBITION
AB This study evaluated the health benefits of carrots (Daucus carota) subjected to post-harvest wounding stress, emphasizing their anti-obesogenic, anti-inflammatory, and antioxidant properties. Carrots were shredded and stored at 15 +/- 2 degrees C for 48 h to induce wounding stress, leading to a significant increase in chlorogenic acid content, by over 112.5 % compared to control. The study utilized 3T3-L1 cell differentiation assays to evaluate the anti-obesogenic potential, monitoring changes in lipid accumulation and adipogenesis-related gene expression. The anti-inflammatory activity was determined in LPS-stimulated RAW 264.7 macrophages by measuring nitrite production, while the antioxidant capacity was assessed using the DCFH-DA assay in Caco-2 cells. Key findings include a notable reduction in lipid accumulation in 3T3-L1 cells with stressed carrot extracts, particularly at 166 mu g/mL concentration, showing an 18 % decrease compared to the control. Furthermore, there was a significant alteration in the expression of adipogenesis-related genes, with a 73 % decrease in FAS expression and a 160 % increase in ATGL expression. The stressed carrot extracts at 125 mu g/mL also exhibited enhanced antiinflammatory activity, inhibiting nitrite production by 44.60 %, a 153.26 % increase over the lower concentration. Additionally, antioxidant activity in stressed carrot extracts increased by 77.15 % at 125 mu g/mL. These results indicate that wounding stress significantly boosts the health-promoting properties of carrots, suggesting their potential as functional foods for combating obesity and metabolic syndrome-related diseases. The study highlights the value of post-harvest treatments in enhancing the nutraceutical quality of vegetables.
C1 [Reza-Zaldivar, Edwin E.; Bojorquez-Rodriguez, Erika Melissa; Jacobo-Velazquez, Daniel A.] Inst Obes Res, Tecnol Monterrey, Ave Gen Ramon Corona 2514, Zapopan 45201, Jalisco, Mexico.
   [Jacobo-Velazquez, Daniel A.] Escuela Ingn & Ciencias, Tecnol Monterrey, Ave Gen Ramon Corona 2514, Zapopan 45138, Jalisco, Mexico.
C3 Tecnologico de Monterrey; Tecnologico de Monterrey
RP Jacobo-Velázquez, DA (corresponding author), Inst Obes Res, Tecnol Monterrey, Ave Gen Ramon Corona 2514, Zapopan 45201, Jalisco, Mexico.
RI Jacobo-Velázquez, Daniel/AAG-5973-2020; Jacobo-Velazquez, Daniel
   Alberto/E-4225-2013
OI Jacobo-Velazquez, Daniel Alberto/0000-0002-9478-2570
FU Challenge-Based Research Funding Grant from Tecnologico de Monterrey
FX This research was conducted with funding from the Challenge-Based
   Research Funding Grant from Tecnologico de Monterrey.
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NR 53
TC 3
Z9 3
U1 0
U2 0
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2666-1543
J9 J AGR FOOD RES
JI J. Agric. Food Res.
PD JUN
PY 2024
VL 16
AR 101155
DI 10.1016/j.jafr.2024.101155
EA APR 2024
PG 9
WC Agriculture, Multidisciplinary; Food Science & Technology
WE Emerging Sources Citation Index (ESCI)
SC Agriculture; Food Science & Technology
GA RS6G4
UT WOS:001229683400001
OA gold
DA 2025-06-11
ER

PT J
AU Ghibu, S
   Craciun, CE
   Rusu, R
   Morgovan, C
   Mogosan, C
   Rochette, L
   Gal, AF
   Dronca, M
AF Ghibu, Steliana
   Craciun, Cristina Elena
   Rusu, Razvan
   Morgovan, Claudiu
   Mogosan, Cristina
   Rochette, Luc
   Gal, Adrian Florin
   Dronca, Maria
TI Impact of Alpha-Lipoic Acid Chronic Discontinuous Treatment in
   Cardiometabolic Disorders and Oxidative Stress Induced by Fructose
   Intake in Rats
SO ANTIOXIDANTS
LA English
DT Article
DE alpha-lipoic acid; antioxidants; fructose-enriched diet; insulin
   resistance; hypertension; oxidative stress
ID SERUM URIC-ACID; INSULIN-RESISTANCE; METABOLIC SYNDROME; ANTIOXIDANT
   PROPERTIES; LIPID PROFILE; CAUSAL ROLE; HYPERTENSION; REDUCTION;
   BYSTANDER; DITHIOL
AB Insulin resistance (IR) and cardiometabolic disorders are the main consequences of today's alimentary behavior. This study evaluates the effects of a chronic-discontinuous treatment with alpha-lipoic acid (AL), an antioxidant substance that improves glycemic control associated with diabetes mellitus, on metabolic disorders and plasma oxidative stress induced by fructose intake, in rats. Sprague-Dawley rats (48 animals) were randomized into two series (n = 24): rats fed with standard chow or with standard chow supplemented with 60% fructose. In each of the two series, for 2 weeks/month over 12 weeks, a group of rats (n = 12) was intraperitoneally injected with NaCl 0.9%, and a second group (n = 12) received AL 50 mg/kg/day. Body weight, glycemia, and systolic blood pressure were monitored throughout the study. After 12 weeks, IR, plasma lipoproteins, uric acid, transaminase activities, and oxidative stress markers were assessed. The high fructose-enriched diet induced cardiometabolic disorders (hypertension, hyperglycemia, IR and dyslipidemia), an increase in uric acid concentration, transaminase activities and C-reactive protein level. This diet also enhanced plasma products of lipid and protein oxidation, homocysteine level, and decreased GSH/GSSG ratio. In this field, there is evidence to indicate that oxidative stress plays an important role in the etiology of diabetic complications. AL discontinuous treatment prevents the metabolic disorders induced by fructose intake, reduced plasma lipid and protein oxidation-products, and restored the GHS/GSSG ratio. Our study proves a promising potential of the chronic-discontinuous treatment of AL and highlights the pleiotropic effects of this antioxidant substance in metabolic disorders such as diabetes.
C1 [Ghibu, Steliana; Mogosan, Cristina] Iuliu Hatieganu Univ Med & Pharm, Fac Pharm, Dept Pharmacol Physiol & Pathophysiol, Cluj Napoca 400349, Romania.
   [Craciun, Cristina Elena] Iuliu Hatieganu Univ Med & Pharm, Fac Pharm, Dept Pharmaceut Biochem & Clin Lab, Cluj Napoca 400349, Romania.
   [Rusu, Razvan; Dronca, Maria] Iuliu Hatieganu Univ Med & Pharm, Fac Med, Dept Med Biochem, Cluj Napoca 400349, Romania.
   [Morgovan, Claudiu] Lucian Blaga Univ Sibiu, Preclin Dept, Sibiu 550169, Romania.
   [Rochette, Luc] Univ Bourgogne Franche Comte, Fac Sci Sante, Physiopathol & Epidemiol Cerebro Cardiovasc PEC2, Equipe Accueil EA 7460, 7 Bd Jeanne Arc, F-21000 Dijon, France.
   [Gal, Adrian Florin] Univ Agr Sci & Vet Med, Fac Vet Med, Dept Cell Biol Histol & Embryol, Cluj Napoca 400372, Romania.
C3 Iuliu Hatieganu University of Medicine & Pharmacy; Iuliu Hatieganu
   University of Medicine & Pharmacy; Iuliu Hatieganu University of
   Medicine & Pharmacy; Lucian Blaga University of Sibiu; Universite
   Bourgogne Europe; University of Agricultural Sciences & Veterinary
   Medicine Cluj Napoca
RP Mogosan, C (corresponding author), Iuliu Hatieganu Univ Med & Pharm, Fac Pharm, Dept Pharmacol Physiol & Pathophysiol, Cluj Napoca 400349, Romania.; Rochette, L (corresponding author), Univ Bourgogne Franche Comte, Fac Sci Sante, Physiopathol & Epidemiol Cerebro Cardiovasc PEC2, Equipe Accueil EA 7460, 7 Bd Jeanne Arc, F-21000 Dijon, France.
EM stelianaghibu@yahoo.com; ecgagyi@yahoo.com; imunorusu@yahoo.com;
   claudiumorgovan@yahoo.com; farmacologiecj@yahoo.com;
   luc.rochette@u-bourgogne.fr; adrian.gal@usamvcluj.ro; m_dronca@yahoo.com
RI Gal, Adrian/IAP-3047-2023; Craciun, Elena Cristina/KBB-1372-2024; Ghibu,
   Steliana/X-4723-2019; Mogosan, Cristina/H-9901-2016; Morgovan,
   Claudiu/C-4748-2011
OI Ghibu, Steliana/0000-0003-2247-4613; GAL, ADRIAN
   FLORIN/0000-0001-5967-4438; Craciun, Elena Cristina/0000-0002-8192-1631;
   Morgovan, Claudiu/0000-0003-2730-8729
FU Ministry of Research and Innovation, CNCS-UEFISCDI within PNCDI III
   [PN-III-P1-1.1-TE-2016-1480]
FX This work was supported by a grant of Ministry of Research and
   Innovation, CNCS-UEFISCDI, project number PN-III-P1-1.1-TE-2016-1480,
   within PNCDI III.
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NR 69
TC 20
Z9 21
U1 0
U2 10
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD DEC
PY 2019
VL 8
IS 12
AR 636
DI 10.3390/antiox8120636
PG 19
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA KB6WN
UT WOS:000506633000069
PM 31835800
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Sinha-Hikim, I
   Sinha-Hikim, AP
   Shen, RQ
   Kim, H
   French, SW
   Vaziri, ND
   Crum, A
   Rajavashisth, TB
   Norris, KC
AF Sinha-Hikim, Indrani
   Sinha-Hikim, Amiya P.
   Shen, Ruoqing
   Kim, H.
   French, Samuel W.
   Vaziri, Nosratola D.
   Crum, Albert
   Rajavashisth, Tripathi B.
   Norris, Keith C.
TI A novel cystine based antioxidant attenuates oxidative stress and
   hepatic steatosis in diet-induced obese mice
SO EXPERIMENTAL AND MOLECULAR PATHOLOGY
LA English
DT Article
DE Antioxidant; Oxidative stress; Apoptosis; High fat diet; Hepatic
   steatosis; Lipogenesis
ID ACTIVATED PROTEIN-KINASE; JUN NH2-TERMINAL KINASE; FATTY LIVER-DISEASE;
   N-ACETYLCYSTEINE; CELL-DEATH; LIPOGENIC ENZYMES; INVOLVEMENT;
   GLUTATHIONE; APOPTOSIS; PATHWAY
AB Nonalcoholic fatty liver disease (NAFLD) is the most common form of liver pathologies and is associated with obesity and the metabolic syndrome. Here, we investigated the molecular mechanisms by which a novel cystine based glutathione precursor with added selenomethionine (F1) prevents hepatic steatosis in a moderate high fat dietary model of NAFLD. Adult (8 weeks old), male apolipoprotein E (ApoE)-/- mice were fed with a normal diet (ND) or high fat diet (HED), consisting of 21% fat and 0.21% cholesterol, with or without dietary supplementation of F1 (3 g/kg food) for 16 weeks. Compared with ApoE-/- mice fed with ND with or without El. ApoE-/- mice fed with HFD exhibited significant weight gain, hepatomegaly, and increased serum cholesterol and triglycerides levels with no change in serum albumin levels. High resolution light and electron microscopy revealed micro-and macro-vesicular steatosis in ApoE-/- mice fed on a HFD. HFD-induced obesity also led to increased lipogenesis, oxidative stress, activation of c-Jun-NH2-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MARC), perturbation of the BAX/BCL-2 rheostat, hepatocyte apoptosis, and activation of caspases 9 and 3. F1 fully prevented the adverse effects of HFD on serum triglyceride levels, body and liver weights, and hepatic steatosis and substantially attenuated HFD-induced increase in lipogenesis, oxidative stress, kinase activation, apoptotic signaling, and hepatocyte ultrastructural abnormalities. These results demonstrate that administration of F1, a glutathione precursor, ameliorates HFD-induced hepatic steatosis in ApoE-/- mice and emphasizes the role of oxidative stress in diet-induced obesity and hepatic steatosis. Published by Elsevier Inc.
C1 [Sinha-Hikim, Indrani; Sinha-Hikim, Amiya P.; Shen, Ruoqing; Rajavashisth, Tripathi B.; Norris, Keith C.] Charles R Drew Univ, Dept Internal Med, Los Angeles, CA USA.
   [Sinha-Hikim, Indrani; Sinha-Hikim, Amiya P.; Rajavashisth, Tripathi B.; Norris, Keith C.] Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90095 USA.
   [Kim, H.; Vaziri, Nosratola D.] Univ Calif Irvine, Div Nephrol & Hypertens, Irvine, CA USA.
   [French, Samuel W.] Harbor UCLA Med Ctr, Dept Pathol, Torrance, CA 90509 USA.
   [Crum, Albert] Proimmune, Rhinebeck, NY USA.
C3 Charles R. Drew University of Medicine & Science; University of
   California System; University of California Los Angeles; University of
   California Los Angeles Medical Center; David Geffen School of Medicine
   at UCLA; University of California System; University of California
   Irvine; University of California System; University of California Los
   Angeles; University of California Los Angeles Medical Center
RP Sinha-Hikim, I (corresponding author), Charles R Drew Univ Med & Sci, Dept Internal Med, 1731 E 120th St, Los Angeles, CA 90059 USA.
EM indranisinhahikim@cdrewu.edu
RI Rajavashisth, Tripathi/ABB-6379-2020
FU NIH-NCCR [U54 RR026138]; NIH [NIMHDP20MD00182]
FX This study was supported by NIH-NCCR Accelerating Excellence in
   Translation Science Grant (U54 RR026138) and NIH-NIMHDP20MD00182.
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NR 57
TC 50
Z9 57
U1 0
U2 16
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0014-4800
EI 1096-0945
J9 EXP MOL PATHOL
JI Exp. Mol. Pathol.
PD AUG
PY 2011
VL 91
IS 1
BP 419
EP 428
DI 10.1016/j.yexmp.2011.04.009
PG 10
WC Pathology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pathology
GA 802ZE
UT WOS:000293548700014
PM 21570964
OA Green Accepted, Green Published
DA 2025-06-11
ER

PT J
AU Allard, JP
   Aghdassi, E
   Mohammed, S
   Raman, M
   Avand, G
   Arendt, BM
   Jalali, P
   Kandasamy, T
   Prayitno, N
   Sherman, M
   Guindi, M
   Ma, DWL
   Heathcote, JE
AF Allard, Johane P.
   Aghdassi, Elaheh
   Mohammed, Saira
   Raman, Maitreyi
   Avand, Ghazal
   Arendt, Bianca M.
   Jalali, Pegah
   Kandasamy, Thileep
   Prayitno, Nita
   Sherman, Morris
   Guindi, Maha
   Ma, David W. L.
   Heathcote, Jenny E.
TI Nutritional assessment and hepatic fatty acid composition in
   non-alcoholic fatty liver disease (NAFLD): A cross-sectional study
SO JOURNAL OF HEPATOLOGY
LA English
DT Article
DE polyunsaturated fatty acids; non-alcoholic fatty liver disease;
   oxidative stress; antioxidants; lipid peroxides
ID INSULIN-RESISTANCE; LIPID-PEROXIDATION; ANTIOXIDANT STATUS; OXIDATIVE
   STRESS; DESATURASE EXPRESSION; METABOLIC SYNDROME; ADIPOSE-TISSUE;
   SATURATED FAT; MURINE MODEL; STEATOHEPATITIS
AB Background/Aims: Low hepatic n - 6 and n - 3 polyunsaturated fatty acid (PUFA) may contribute to steatosis and steatohepatitis and can be affected by diet and oxidative stress.
   Methods: Seventy-three patients referred for elevated liver enzymes and suspected NAFLD were assessed. Nutritional assessment, hepatic FA composition and oxidative stress were compared between these groups: simple steatosis (SS, n = 18), steatohepatitis (NASH, n = 38) and minimal findings on liver biopsy (MF, n = 17).
   Results: Patients with NASH had higher: BMI, central obesity, body fat, insulin resistance, dyslipidemia and lower physical activity compared to the other groups. They also had relatively lower hepatic n - 3 and n - 6 PUFA, a decrease in the ratio of metabolites to essential FA precursors for both n - 6 and it - 3 FA (eicosapentaenoic + docosahexaenoic/ linolenic and arachidonic/linoleic acid ratios) and higher liver lipid peroxides with lower antioxidant power, when compared to ME Overall, there was no significant difference between SS and NASH in FA composition. Self-reported dietary intake and red blood cell FA composition were similar among the three groups.
   Conclusions: NASH patients have more metabolic abnormalities. This is associated with higher oxidative stress and lower n - 3 and n - 6 PUFA in the liver in the absence of any differences in dietary FA composition. (c) 2007 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
C1 Univ Toronto, Toronto Gen Hosp, Toronto, ON M5G 2C4, Canada.
   Univ Hlth Network, Toronto Gen Hosp, Toronto, ON M5G 2C4, Canada.
C3 University of Toronto; University Health Network Toronto; Toronto
   General Hospital; University of Toronto; University Health Network
   Toronto; Toronto General Hospital
RP Allard, JP (corresponding author), Univ Toronto, Toronto Gen Hosp, 200 Elizabeth St 9N-973, Toronto, ON M5G 2C4, Canada.
EM johane.allard@uhn.on.ca
OI Ma, David/0000-0002-1165-5972
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NR 68
TC 210
Z9 273
U1 2
U2 32
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0168-8278
EI 1600-0641
J9 J HEPATOL
JI J. Hepatol.
PD FEB
PY 2008
VL 48
IS 2
BP 300
EP 307
DI 10.1016/j.jhep.2007.09.009
PG 8
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 264XS
UT WOS:000253324300015
PM 18086506
DA 2025-06-11
ER

PT J
AU Hasan, MK
   Friedman, TC
   Sims, C
   Lee, DL
   Espinoza-Derout, J
   Ume, A
   Chalfant, V
   Lee, ML
   Sinha-Hikim, I
   Lutfy, K
   Liu, YJ
   Mahata, SK
   Sinha-Hikim, AP
AF Hasan, Mohammad Kamrul
   Friedman, Theodore C.
   Sims, Carl
   Lee, Desean L.
   Espinoza-Derout, Jorge
   Ume, Adaku
   Chalfant, Victor
   Lee, Martin L.
   Sinha-Hikim, Indrani
   Lutfy, Kabirullah
   Liu, Yanjun
   Mahata, Sushil K.
   Sinha-Hikim, Amiya P.
TI α7-Nicotinic Acetylcholine Receptor Agonist Ameliorates Nicotine Plus
   High-Fat Diet-Induced Hepatic Steatosis in Male Mice by Inhibiting
   Oxidative Stress and Stimulating AMPK Signaling
SO ENDOCRINOLOGY
LA English
DT Article
ID INSULIN-RESISTANCE; METABOLIC SYNDROME; HEME OXYGENASE-1; LIVER
   STEATOSIS; MOUSE MODEL; ACTIVATION; APOPTOSIS; OBESITY; INVOLVEMENT;
   HOMEOSTASIS
AB alpha 7-Nicotinic acetylcholine receptor (alpha 7nAChR) agonists confer protection against a wide variety of cytotoxic insults and suppress oxidative stress and apoptosis in various cell systems, including hepatocytes. We recently demonstrated that nicotine, when combined with a high-fat diet (HFD), triggers oxidative stress, activates hepatocyte apoptosis, and exacerbates HFD-induced hepatic steatosis in male mice. This study evaluates whether PNU-282987 (PNU), a specific alpha 7nAChR agonist, is effective in preventing nicotine plus HFD-induced hepatic steatosis. Adult C57BL6 male mice were fed a normal chow diet or HFD with 60% of calories derived from fat and received twice-daily intraperitoneal injections of 0.75 mg/kg body weight (BW) of nicotine, PNU (0.26 mg/kg BW), PNU plus nicotine, or saline for 10 weeks. PNU treatment was effective in attenuating nicotine plus HFD-induced increase in hepatic triglyceride levels, hepatocyte apoptosis, and hepatic steatosis. The preventive effects of PNU on nicotine plus HFD-induced hepatic steatosis were mediated by suppression of oxidative stress and activation of adenosine 5'-monophosphate-activated protein kinase (AMPK) together with inhibition of its downstream target sterol regulatory element binding protein 1c (SREBP1c), fatty acid synthase (FAS), and acetyl-coenzyme A-carboxylase (ACC). We conclude that the alpha 7nAChR agonist PNU protects against nicotine plus HFD-induced hepatic steatosis in obese mice. PNU appears to work at various steps of signaling pathways involving suppression of oxidative stress, activation of AMPK, and inhibition of SREBP1c, FAS, and ACC. alpha 7nAChR agonists may be an effective therapeutic strategy for ameliorating fatty liver disease, especially in obese smokers.
C1 [Hasan, Mohammad Kamrul; Friedman, Theodore C.; Sims, Carl; Lee, Desean L.; Espinoza-Derout, Jorge; Ume, Adaku; Chalfant, Victor; Lee, Martin L.; Sinha-Hikim, Indrani; Liu, Yanjun; Sinha-Hikim, Amiya P.] Charles R Drew Univ Med & Sci, Dept Internal Med, Div Endocrinol Metab & Mol Med, 1621 E 120th St, Los Angeles, CA 90059 USA.
   [Friedman, Theodore C.; Lee, Martin L.; Sinha-Hikim, Indrani; Sinha-Hikim, Amiya P.] Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90095 USA.
   [Lutfy, Kabirullah] Western Univ Hlth Sci, Coll Pharm, Pomona, CA 91766 USA.
   [Mahata, Sushil K.] Univ Calif San Diego, Dept Med, San Diego, CA 92093 USA.
   [Mahata, Sushil K.] VA San Diego Hlth Care Syst, San Diego, CA 92161 USA.
C3 Charles R. Drew University of Medicine & Science; University of
   California System; University of California Los Angeles; University of
   California Los Angeles Medical Center; David Geffen School of Medicine
   at UCLA; Western University of Health Sciences; University of California
   System; University of California San Diego; US Department of Veterans
   Affairs; Veterans Health Administration (VHA); VA San Diego Healthcare
   System
RP Hasan, MK; Sinha-Hikim, AP (corresponding author), Charles R Drew Univ Med & Sci, Dept Internal Med, 1731 E 120th St, Los Angeles, CA 90059 USA.
EM kamrulhasan@cdrewu.edu; amiyasinhahikim@cdrewu.edu
RI Lutfy, Kabirullah/H-9995-2019; Mahata, Sushil/AAF-8781-2021; LEE,
   DAE-HEE/O-5243-2018; 刘, 严君/GZL-5764-2022
OI Lee, Darrall/0000-0002-6990-4441
FU Diversity-Promoting Institution Drug Abuse Research Program
   [R24DA017298]; Accelerating Excellence in Translational Science Grant
   from the National Institutes of Health, National Institute on Minority
   Health and Health Disparities [2U54MD007598]
FX This work was supported by Diversity-Promoting Institution Drug Abuse
   Research Program Grant R24DA017298 (to A.P.S.-H.) and Accelerating
   Excellence in Translational Science Grant 2U54MD007598 from the National
   Institutes of Health, National Institute on Minority Health and Health
   Disparities.
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NR 67
TC 31
Z9 35
U1 0
U2 8
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0013-7227
EI 1945-7170
J9 ENDOCRINOLOGY
JI Endocrinology
PD FEB
PY 2018
VL 159
IS 2
BP 931
EP 944
DI 10.1210/en.2017-00594
PG 14
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA FY9ZP
UT WOS:000427226200030
PM 29272360
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Chandrashekar, L
   Kumari, GRK
   Rajappa, M
   Revathy, G
   Munisamy, M
   Thappa, DM
AF Chandrashekar, L.
   Kumari, G. R. Krishna
   Rajappa, M.
   Revathy, G.
   Munisamy, M.
   Thappa, D. M.
TI 25-hydroxy vitamin D and ischaemia-modified albumin levels in psoriasis
   and their association with disease severity
SO BRITISH JOURNAL OF BIOMEDICAL SCIENCE
LA English
DT Article
DE Inflammation; Oxidative stress; Psoriasis Area Severity Index;
   Psoriasis; Vitamin D
ID C-REACTIVE PROTEIN; VULGARIS; DEFICIENCY; MARKER
AB Psoriasis is a T-helper-1 (Th1)/Th17-mediated chronic inflammatory skin disease, characterised by hyperproliferation of keratinocytes. Psoriasis and cardiovascular disease share similar pathogenic mechanisms such as vascular endothelial cell dysfunction, oxidative stress and metabolic syndrome. 25-hydroxy vitamin D is an immune-regulatory hormone, with the ability to reduce cellular proliferation in psoriasis. Ischaemia-modified albumin (IMA) is a marker of oxidative stress. This study examined 25-hydroxy vitamin D, IMA and high-sensitivity C-reactive protein (hs-CRP) levels in patients with psoriasis, in comparison with healthy controls and their possible association with disease severity. A total of 43 cases of psoriasis and 43 controls were included in this cross-sectional study, and severity grading was performed according to psoriasis area severity index (PASI) scoring. Serum 25-hydroxy vitamin D, IMA and hs-CRP were evaluated in all study subjects. In psoriasis, 25-hydroxy vitamin D showed a significant decline, while hs-CRP and IMA levels were significantly elevated, as compared with controls. Serum 25-hydroxy vitamin D showed a significant negative correlation with PAST score. hs-CRP and IMA showed a significant positive correlation with PAST score. Significant negative correlation was observed between 25-hydroxy vitamin D and hs-CRP; 25-hydroxy vitamin D and IMA levels in psoriasis. The results indicate that psoriasis is associated with significantly lowered 25-hydroxy vitamin D levels, along with increased systemic inflammation and oxidative stress, especially in severe disease. Thus, vitamin D supplementation might reduce systemic inflammation and oxidative stress and help in delaying the pathogenesis of co-morbidities associated with psoriasis.
C1 [Chandrashekar, L.; Revathy, G.; Munisamy, M.; Thappa, D. M.] Jawaharlal Inst Postgrad Med Educ & Res, Dept Dermatol, Pondicherry, India.
   [Kumari, G. R. Krishna; Rajappa, M.] Jawaharlal Inst Postgrad Med Educ & Res, Dept Biochem, Pondicherry, India.
C3 Jawaharlal Institute of Postgraduate Medical Education & Research;
   Jawaharlal Institute of Postgraduate Medical Education & Research
RP Rajappa, M (corresponding author), Jawaharlal Inst Postgrad Med Educ & Res, Dept Biochem, Dhanvantari Nagar 605006, Puducherry, India.
EM linkmedha@gmail.com
RI Chandrashekar, Laxmisha/C-7070-2014; Munisamy, Malathi/IUP-9636-2023;
   RAJAPPA, MEDHA/AAU-5292-2020; Thappa, Devinder/A-2899-2017
OI RAJAPPA, MEDHA/0000-0001-7725-9676; Munisamy,
   Malathi/0000-0001-5574-7943; Revathy, Gunaseelan/0000-0003-2158-8520;
   Thappa, Devinder/0000-0003-2207-8848
FU JIPMER, Puducherry, India
FX Intramural funding from JIPMER, Puducherry, India. for this research
   work is gratefully acknowledged.
CR Bar-Or D, 2000, J EMERG MED, V19, P311, DOI 10.1016/S0736-4679(00)00255-9
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NR 25
TC 43
Z9 43
U1 0
U2 7
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0967-4845
J9 BRIT J BIOMED SCI
JI Br. J. Biomed. Sci.
PY 2015
VL 72
IS 2
BP 56
EP 60
PG 5
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA CK4OH
UT WOS:000356202600002
PM 26126320
DA 2025-06-11
ER

PT J
AU Tucsek, Z
   Toth, P
   Sosnowska, D
   Gautam, T
   Mitschelen, M
   Koller, A
   Szalai, G
   Sonntag, WE
   Ungvari, Z
   Csiszar, A
AF Tucsek, Zsuzsanna
   Toth, Peter
   Sosnowska, Danuta
   Gautam, Tripti
   Mitschelen, Matthew
   Koller, Akos
   Szalai, Gabor
   Sonntag, William E.
   Ungvari, Zoltan
   Csiszar, Anna
TI Obesity in Aging Exacerbates Blood-Brain Barrier Disruption,
   Neuroinflammation, and Oxidative Stress in the Mouse Hippocampus:
   Effects on Expression of Genes Involved in Beta-Amyloid Generation and
   Alzheimer's Disease
SO JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL
   SCIENCES
LA English
DT Article
DE Adipose; Metabolic syndrome; Insulin resistance; Alzheimer's disease;
   Blood
ID HIGH-FAT-DIET; IMPAIRS ANGIOGENIC CAPACITY; ADIPOSE-TISSUE; COGNITIVE
   IMPAIRMENT; INSULIN-RESISTANCE; CARDIOVASCULAR HEALTH; IGF-1 DEFICIENCY;
   MEMORY DEFICIT; SATURATED FAT; WESTERN DIET
AB There is growing evidence that obesity has deleterious effects on the brain and cognitive function in the elderly population. However, the specific mechanisms through which aging and obesity interact to promote cognitive decline remain unclear. To test the hypothesis that aging exacerbates obesity-induced cerebromicrovascular damage and neuroinflammation, we compared young (7 months) and aged (24 months) high fat diet-fed obese C57BL/6 mice. Aging exacerbated obesity-induced systemic inflammation and blood-brain barrier disruption, as indicated by the increased circulating levels of proinflammatory cytokines and increased presence of extravasated immunoglobulin G in the hippocampus, respectively. Obesity-induced blood-brain barrier damage was associated with microglia activation, upregulation of activating Fc-gamma receptors and proinflammatory cytokines, and increased oxidative stress. Treatment of cultured primary microglia with sera derived from aged obese mice resulted in significantly more pronounced microglia activation and oxidative stress, as compared with treatment with young sera. Serum-induced activation and oxidative stress were also exacerbated in primary microglia derived from aged animals. Hippocampal expression of genes involved in regulation of the cellular amyloid precursor protein-dependent signaling pathways, beta-amyloid generation, and the pathogenesis of tauopathy were largely unaffected by obesity in aged mice. Collectively, obesity in aging is associated with a heightened state of systemic inflammation, which exacerbates blood-brain barrier disruption. The resulting neuroinflammation and oxidative stress in the mouse hippocampus likely contribute to the significant cognitive decline observed in aged obese animals.
C1 [Tucsek, Zsuzsanna; Toth, Peter; Sosnowska, Danuta; Gautam, Tripti; Mitschelen, Matthew; Sonntag, William E.; Ungvari, Zoltan; Csiszar, Anna] Univ Oklahoma, Hlth Sci Ctr, Donald W Reynolds Dept Geriatr Med, Reynolds Oklahoma Ctr Aging, Oklahoma City, OK 73104 USA.
   [Koller, Akos; Ungvari, Zoltan; Csiszar, Anna] Univ Pecs, Sch Med, Dept Pathophysiol & Gerontol, Pecs, Hungary.
   [Koller, Akos; Ungvari, Zoltan; Csiszar, Anna] Univ Pecs, Szentagothai Res Ctr, Pecs, Hungary.
   [Szalai, Gabor] Univ S Carolina, Dept Biol Sci, Columbia, SC 29208 USA.
   [Sonntag, William E.; Ungvari, Zoltan; Csiszar, Anna] Univ Oklahoma, Hlth Sci Ctr, Peggy & Charles Stephenson Canc Ctr, Oklahoma City, OK 73104 USA.
C3 University of Oklahoma System; University of Oklahoma Health Sciences
   Center; University of Pecs; University of Pecs; University of South
   Carolina System; University of South Carolina Columbia; University of
   Oklahoma System; University of Oklahoma Health Sciences Center
RP Ungvari, Z (corresponding author), Univ Oklahoma, Dept Geriatr Med, Reynolds Oklahoma Ctr Aging, HSC, 975 NE 10th St,BRC 1303, Oklahoma City, OK 73104 USA.
EM zoltan-ungvari@ouhsc.edu
RI Ungvari, Zoltan/GZK-8127-2022; Sosnowska, Danuta/KHD-9993-2024; Ákos,
   Koller/Q-4672-2019; Szalai, Gabor/ABA-4146-2021
OI Sonntag, William/0000-0003-1850-2407; Sosnowska,
   Danuta/0000-0002-2291-5987
FU American Heart Association; National Center for Complementary and
   Alternative Medicine [R01-AT006526]; National Institute on Aging
   [AG031085, AG038747]; American Federation for Aging Research; Oklahoma
   Center for the Advancement of Science and Technology; Hungarian
   Scientific Research Fund (OTKA) [K 108444]; Nemzeti Fejlesztesi
   Ugynokseg [SROP-4.2.2.a-11/1/KONV-2012-0024,
   SROP-4.2.2.a-11/1/KONV-2012-0017]; Ellison Medical Foundation
FX This work was supported by grants from the American Heart Association
   (to P. T., A. C., and Z.U.), the National Center for Complementary and
   Alternative Medicine (R01-AT006526 to Z.U.); the National Institute on
   Aging (AG031085 to A. C.; AG038747 to W. E. S.), the American Federation
   for Aging Research (to A. C.), the Oklahoma Center for the Advancement
   of Science and Technology (to A. C., Z.U., and W. E. S.), Hungarian
   Scientific Research Fund (OTKA; K 108444) and the Nemzeti Fejlesztesi
   Ugynokseg (SROP-4.2.2.a-11/1/KONV-2012-0024 and -0017 to Z.U. and A.K.),
   and the Ellison Medical Foundation (to W.E.S.).
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NR 64
TC 255
Z9 279
U1 0
U2 63
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1079-5006
EI 1758-535X
J9 J GERONTOL A-BIOL
JI J. Gerontol. Ser. A-Biol. Sci. Med. Sci.
PD OCT
PY 2014
VL 69
IS 10
BP 1212
EP 1226
DI 10.1093/gerona/glt177
PG 15
WC Geriatrics & Gerontology; Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA AR2JJ
UT WOS:000343410000004
PM 24269929
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Sowers, KM
   Hayden, MR
AF Sowers, Kurt M.
   Hayden, Melvin R.
TI Calcific uremic arteriolopathy Pathophysiology, reactive oxygen species
   and therapeutic approaches
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Review
DE calcific obliterative arteriolopathy; calciphylaxis; fetuin-A;
   inflammation; oxidative stress; sodium thiosulfate; ultrastructure;
   vascular calcification
ID INTRAVENOUS-SODIUM THIOSULFATE; ENDOTHELIAL MICROPARTICLES; VASCULAR
   CALCIFICATION; METABOLIC SYNDROME; OXIDATIVE STRESS; RENAL-FUNCTION;
   REDOX STRESS; RISK-FACTORS; IN-VIVO; CALCIPHYLAXIS
AB Calcific uremic arteriolopathy (CUA)/calciphylaxis is an important cause of morbidity and mortality in patients with chronic kidney disease requiring renal replacement. Once thought to be rare, it is being increasingly recognized and reported on a global scale. The uremic milieu predisposes to multiple metabolic toxicities including increased levels of reactive oxygen species and inflammation. Increased oxidative stress and inflammation promote this arteriolopathy by adversely affecting endothelial function resulting in a prothrombotic milieu and significant remodeling effects on vascular smooth muscle cells. These arteriolar pathological effects include intimal hyperplasia, inflammation, endovascular fibrosis and vascular smooth muscle cell apoptosis and differentiation into bone forming osteoblast-like cells resulting in medial calcification. Systemic factors promoting this vascular condition include elevated calcium, parathyroid hormone and hyperphosphatennia with consequent increases in the calcium x phosphate product. The uremic milieu contributes to a marked increased in upstream reactive oxygen species oxidative stress and subsequent downstream increased inflammation, in part, via activation of the nuclear transcription factor NF kappa B:3 and associated downstream cytokine pathways. Consitutive anti-calcification proteins such as Fetuin-A and matrix GLA proteins and their signaling pathways may be decreased, which further contributes to medial vascular calcification. The resulting clinical entity is painful, debilitating and contributes to the excess morbidity and mortality associated with chronic kidney disease and end stage renal disease. These same histopathologic conditions also occur in patients without uremia and therefore, the term calcific obliterative arteriolopathy could be utilized in these conditions.
C1 [Hayden, Melvin R.] Univ Missouri, Sch Med, Dept Internal Med, Columbia, MO 65211 USA.
   [Sowers, Kurt M.] Univ Maryland, Div Nephrol, College Pk, MD 20742 USA.
   [Sowers, Kurt M.] Univ Maryland, Div Physiol, College Pk, MD 20742 USA.
   [Hayden, Melvin R.] Univ Missouri, Sch Med, Dept Diabet Endocrinol & Metab, Columbia, MO 65211 USA.
   [Hayden, Melvin R.] Univ Missouri, Sch Med, Diabet & Cardiovasc Dis Res Ctr, Columbiaville, MI USA.
C3 University of Missouri System; University of Missouri Columbia;
   University System of Maryland; University of Maryland College Park;
   University System of Maryland; University of Maryland College Park;
   University of Missouri System; University of Missouri Columbia;
   University of Missouri System; University of Missouri Columbia
RP Hayden, MR (corresponding author), Univ Missouri, Sch Med, Dept Internal Med, Columbia, MO 65211 USA.
EM mrh29@usmo.com
FU National Kidney Foundation
FX Authors wish to thank James R. Sowers, Director Cosmopolitan
   International Diabetes and Cardiovascular Center of the University of
   Missouri, School of Medicine; Columbia, Missouri for providing editorial
   assistance. Funding support has been provided by National Kidney
   Foundation Nephrology Fellow Basic Science Grant (K.M.S.).
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NR 78
TC 103
Z9 118
U1 0
U2 9
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PD MAR-APR
PY 2010
VL 3
IS 2
BP 109
EP 121
DI 10.4161/oxim.3.2.11354
PG 13
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA 644OW
UT WOS:000281389700005
PM 20716935
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Tunyan, LG
   Chilingaryan, AL
   Adamyan, KG
   Tumasyan, LR
   Kzhdryan, HK
   Zelveian, PH
AF Tunyan, L. G.
   Chilingaryan, A. L.
   Adamyan, K. G.
   Tumasyan, L. R.
   Kzhdryan, H. K.
   Zelveian, P. H.
TI Right ventricular and right atrial free wall deformation predicitive
   value in transformation of preclinical diastolic disfunction to heart
   failure with preserved ejection fraction
SO KARDIOLOGIYA
LA English
DT Article
DE Diastolic dysfunction; heart failure; preserved ejection fraction;
   longitudinal strain
ID EUROPEAN ASSOCIATION; AMERICAN SOCIETY; PROGRESSION; ECHOCARDIOGRAPHY;
   RECOMMENDATIONS; UPDATE
AB Aim To study echocardiographic parameters of heart chamber strain in patients with left ventricular (LV) preclinical diastolic dysfunction (PDD) for determining predictors of the PDD transition to heart failure with preserved LV ejection fraction (HFpEF).
   Material and methods The study included 113 patients (including 69 women) with metabolic syndrome and LV PDD (mean age, 65 +/- 7 years). The control group consisted of 40 healthy individuals (mean age, 63.0 +/- 6.0 years, including 59% women). Metabolic syndrome was diagnosed in consistency with criteria of NCEP-ATP III 2001. PDD was diagnosed based on the absence of heart failure symptoms, normal level of brain natriuretic peptide, and the presence of at least three of the following echocardiographic criteria at rest or after diastolic stress echocardiography (stress-echoCG): left atrial volume index (LAVI) >34 ml/m(2); the ratio of peak early transmitral filling velocity (E) to average lateral and medial mitral annular velocity (e'),E/e' >14,e' <8.5, and peak tricuspid regurgitation velocity >2.8 m/s. EchoCG that determined LV longitudinal strain (LS), right ventricular (RV) LS, right atrial (RA) LS, and left atrial (LA) LS was performed every year during the 3-year follow-up.
   Results During the follow-up period, 31 patients developed HFpEF. 19 of them reported symptoms while in the other 12 patients, HFpEF was detected by diastolic stress-echoCG. Patients with HFpEF had significantly lower absolute values of RV LS, LA LS, and RA LS (- 27.8 +/- 2.9 in the PDD group vs. -23.8 +/- 3.2 in the HFpEF group; p<0.03; 38.2 +/- 9.1 vs. 28.6 +/- 10.2; p<0.03; and 46.2 +/- 10.4 vs. 31.6 +/- 8.3; p<0.03, respectively). RV LS and RA LS were the strongest independent predictors for PDD transformation into HFpEF (odds ratio, OR, 2.7; 95% confidence interval, CI, 1.48-2.91;p<0.001 and OR 2.6; 95% CI: 1.40-2.75;p<0.001, respectively).
   Conclusion PDD is not a separate clinical nosology but rather an initial stage in the pathogenesis of HFpEF. Approximately. of PDD patients develop HFpEF. RV LS and RA LS are considered predictors of HFpEF. The duration of PDD is apparently an important factor that provides the development of HFpEF.
C1 [Tunyan, L. G.; Chilingaryan, A. L.; Adamyan, K. G.; Tumasyan, L. R.; Kzhdryan, H. K.; Zelveian, P. H.] Oganesyan Res Inst Cardiol, Yerevan, Armenia.
   [Tunyan, L. G.; Chilingaryan, A. L.; Adamyan, K. G.; Kzhdryan, H. K.] Mkhitar Heratsi Yerevan State Med Univ, Yerevan, Armenia.
RP Tunyan, LG (corresponding author), Oganesyan Res Inst Cardiol, Yerevan, Armenia.; Tunyan, LG (corresponding author), Mkhitar Heratsi Yerevan State Med Univ, Yerevan, Armenia.
EM Lusine@tunyan.com
RI Zelveian, Parounak/P-8603-2017; Chilingaryan, Aram/Y-7808-2018
OI Zelveian, Parounak/0000-0002-6513-6772; Chilingaryan,
   Aram/0000-0002-9821-7114
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NR 19
TC 1
Z9 1
U1 0
U2 5
PU RUSSIAN HEART FAILURE SOC
PI MOSCOW
PA 215, 5, BEREGOVOY PROEZD, MOSCOW, 121087, RUSSIA
SN 0022-9040
J9 KARDIOLOGIYA
JI Kardiologiya
PY 2023
VL 63
IS 8
BP 33
EP 41
DI 10.18087/cardio.2023.8.n1682
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA Y1TK8
UT WOS:001103158800005
PM 37691503
OA hybrid
DA 2025-06-11
ER

PT J
AU Luo, CH
   Lian, XK
   Hong, LL
   Zou, JF
   Li, Z
   Zhu, YZ
   Huang, TL
   Zhang, YN
   Hu, YQ
   Yuan, H
   Wen, TF
   Zhuang, WL
   Cai, BZ
   Zhang, X
   Hisatome, I
   Yamamoto, T
   Huang, JX
   Cheng, JD
AF Luo, Chaohuan
   Lian, Xueke
   Hong, Liangli
   Zou, Jingfang
   Li, Zhi
   Zhu, Yuzhang
   Huang, Tianliang
   Zhang, Yongneng
   Hu, Yaqiu
   Yuan, Huier
   Wen, Tengfei
   Zhuang, Wanling
   Cai, Bozhi
   Zhang, Xin
   Hisatome, Ichiro
   Yamamoto, Tetsuya
   Huang, Jiexiong
   Cheng, Jidong
TI High Uric Acid Activates the ROS-AMPK Pathway, Impairs CD68 Expression
   and Inhibits OxLDL-Induced Foam-Cell Formation in a Human Monocytic Cell
   Line, THP-1
SO CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
LA English
DT Article
DE High uric acid; Monocytes/macrophages; ROS-AMPK pathway; CD68; Foam cell
   formation
ID LOW-DENSITY-LIPOPROTEIN; NF-KAPPA-B; PROTEIN-KINASE; IMMUNE-RESPONSE;
   MACROPHAGE POLARIZATION; SURFACE EXPRESSION; INSULIN-RESISTANCE;
   OXIDATIVE STRESS; URATE OXIDASE; HYPERURICEMIA
AB Background/Aims: Hyperuricemia is part of the metabolic-syndrome cluster of abdominal obesity, impaired glucose tolerance, insulin resistance, dyslipidemia, and hypertension. Monocytes/macrophages are critical in the development of metabolic syndrome, including gout, obesity and atherosclerosis. However, how high uric acid (HUA) exposure affects monocyte/macrophage function remains unclear. In this study, we investigated the molecular mechanism of HUA exposure in monocytes/macrophages and its impact on oxidized low density lipoprotein (oxLDL)-induced foam-cell formation in a human monocytic cell line, THP-1. Methods: We primed THP-1 cells with phorbol-12-myristate-13-acetate (PMA) for differentiation, then exposed cells to HUA and detected the production of reactive oxygen species (ROS) and analyzed the level of phospho-AMPK alpha. THP-1 cells were pre-incubated with Compound C, an AM PK inhibitor, or N-acetyl-L-cysteine (NAC), a ROS scavenger, or HUA before PMA, to assess CD68 expression and phospho-AMPKa level. PMA-primed THP-1 cells were pre-treated with oxLDL before Compound C and HUA treatment. Western blot analysis was used to examine the levels of phospho-AMPKa, CD68, ABCG1, ABCA1, cyclooxygenase-2 (COX-2) and NF-KB (p65). Flow cytometry was used to assess ROS production and CD68 expression in live cells. Oil-red 0 staining was used to observe oxLDL uptake in cells. Results: HUA treatment increased ROS production in PMA-primed THP-1 cells; NAC blocked HUA-induced oxidative stress. HUA treatment time-dependently increased phospho-AMPK alpha level in PMA-primed THP-1 cells. The HUA-induced oxidative stress increased phospho-AMPK alpha levels, which was blocked by NAC. HUA treatment impaired CD68 expression during cell differentiation by activating the AMPK pathway, which was reversed by Compound C treatment. Finally, HUA treatment inhibited oxLDL uptake in the formation of foam cells in THP-1 cells, which was blocked by Compound C treatment. HUA treatment significantly increased the expression of ABCG1 and reversed the oxLDL-reduced ABCG1 expression but did not affect the expression of ABCA1, NE-kappa B (p65) or COX-2. Conclusions: HUA exposure activated the ROS-AMPK pathway, impaired CD68 expression, and inhibited oxLDL-induced foam-cell formation in a human monocytic cell line, THP-1. (C) 2016 The Authorts) Published by S. Karger AG, Basel.
C1 [Luo, Chaohuan; Zou, Jingfang; Li, Zhi; Zhu, Yuzhang; Huang, Tianliang; Zhang, Yongneng; Hu, Yaqiu; Yuan, Huier; Wen, Tengfei; Zhuang, Wanling; Cheng, Jidong] Shantou Univ, Coll Med, Dept Internal Med, Affiliated Hosp 1, Shantou 515031, Guangdong, Peoples R China.
   [Hong, Liangli; Huang, Jiexiong] Shantou Univ, Coll Med, Dept Pathol, Affiliated Hosp 1, Shantou, Peoples R China.
   [Cai, Bozhi; Zhang, Xin] Shantou Univ, Coll Med, Mol Cardiol Lab, Affiliated Hosp 1, Shantou, Peoples R China.
   [Lian, Xueke] Guangzhou Univ Chinese Med, Trop Med Inst, Guangzhou, Guangdong, Peoples R China.
   [Hisatome, Ichiro] Tottori Univ, Grad Sch Med Sci, Inst Regenerat Med & Biofunct, Div Regenerat Med & Therapeutics, Yonago, Tottori, Japan.
   [Yamamoto, Tetsuya] Hyogo Coll Med, Dept Internal Med, Nishinomiya, Hyogo, Japan.
C3 Shantou University; Shantou University; Shantou University; Guangzhou
   University of Chinese Medicine; Tottori University; Hyogo Medical
   University
RP Cheng, JD (corresponding author), Shantou Univ, Coll Med, Dept Internal Med, Affiliated Hosp 1, Shantou 515031, Guangdong, Peoples R China.
EM jidongcheng36@hotmail.com
RI Zhu, Yuzhang/AIC-6505-2022; Hong, Liangli/NBX-5504-2025
FU National Natural Science Foundation of China [81570772]; Natural Science
   Foundation of Guangdong Province [2015A030313434]; Scientific Research
   Foundation for the Returned Overseas Chinese Scholars, State Education
   Ministry [20111568]
FX This work was supported by grants from the National Natural Science
   Foundation of China (81570772), the Natural Science Foundation of
   Guangdong Province (2015A030313434) and the Project Sponsored by the
   Scientific Research Foundation for the Returned Overseas Chinese
   Scholars, State Education Ministry (20111568). The experiments were
   mainly carried out in the central laboratory of the First Affiliated
   Hospital, Shantou University Medical College.
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NR 50
TC 45
Z9 49
U1 0
U2 37
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1015-8987
EI 1421-9778
J9 CELL PHYSIOL BIOCHEM
JI Cell. Physiol. Biochem.
PY 2016
VL 40
IS 3-4
BP 538
EP 548
DI 10.1159/000452567
PG 11
WC Cell Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Physiology
GA EH0CP
UT WOS:000391430400012
PM 27889764
OA gold
DA 2025-06-11
ER

PT J
AU Dashti, Z
   Yousefi, Z
   Kiani, P
   Taghizadeh, M
   Maleki, MH
   Borji, M
   Vakili, O
   Shafiee, SM
AF Dashti, Zahra
   Yousefi, Zeynab
   Kiani, Pouria
   Taghizadeh, Motahareh
   Maleki, Mohammad Hasan
   Borji, Mohammad
   Vakili, Omid
   Shafiee, Sayed Mohammad
TI Autophagy and the unfolded protein response shape the non-alcoholic
   fatty liver landscape: decoding the labyrinth
SO METABOLISM-CLINICAL AND EXPERIMENTAL
LA English
DT Article
DE Non-alcoholic fatty liver disease; Autophagy; Unfolded protein response;
   Metabolism; Endoplasmic reticulum stress
ID DE-NOVO LIPOGENESIS; INSULIN-RESISTANCE; HEPATIC STEATOSIS; OXIDATIVE
   STRESS; ER STRESS; DISEASE; SENESCENCE; MICE; ACTIVATION; INHIBITION
AB The incidence of nonalcoholic fatty liver disease (NAFLD) is on the rise, mirroring a global surge in diabetes and metabolic syndrome, as its major leading causes. NAFLD represents a spectrum of liver disorders, ranging from nonalcoholic fatty liver (NAFL) to nonalcoholic steatohepatitis (NASH), which can potentially progress to cirrhosis and hepatocellular carcinoma (HCC). Mechanistically, we know the unfolded protein response (UPR) as a protective cellular mechanism, being triggered under circumstances of endoplasmic reticulum (ER) stress. The hepatic UPR is turned on in a broad spectrum of liver diseases, including NAFLD. Recent data also defines molecular mechanisms that may underlie the existing correlation between UPR activation and NAFLD. More interestingly, subsequent studies have demonstrated an additional mechanism, i.e. autophagy, to be involved in hepatic steatosis, and thus NAFLD pathogenesis, principally by regulating the insulin sensitivity, hepatocellular injury, innate immunity, fibrosis, and carcinogenesis. All these findings suggest possible mechanistic roles for autophagy in the progression of NAFLD and its complications. Both UPR and autophagy are dynamic and interconnected fluxes that act as protective responses to minimize the harmful effects of hepatic lipid accumulation, as well as the ER stress during NAFLD. The functions of UPR and autophagy in the liver, together with findings of decreased hepatic autophagy in correlation with conditions that predispose to NAFLD, such as obesity and aging, suggest that autophagy and UPR, alone or combined, may be novel therapeutic targets against the disease. In this review, we discuss the current evidence on the interplay between autophagy and the UPR in connection to the NAFLD pathogenesis.
C1 [Dashti, Zahra] Shahid Sadoughi Univ Med Sci, Fac Med, Dept Genet, Yazd, Iran.
   [Yousefi, Zeynab] Tarbiat Modares Univ, Fac Med Sci, Dept Clin Biochem, Tehran, Iran.
   [Kiani, Pouria; Vakili, Omid] Isfahan Univ Med Sci, Dept Clin Biochem, Sch Pharm & Pharmaceut Sci, Esfahan, Iran.
   [Taghizadeh, Motahareh; Maleki, Mohammad Hasan] Shiraz Univ Med Sci, Sch Med, Dept Clin Biochem, Shiraz, Iran.
   [Borji, Mohammad] Zanjan Univ Med Sci, Sch Med, Dept Clin Biochem, Zanjan, Iran.
   [Vakili, Omid; Shafiee, Sayed Mohammad] Shiraz Univ Med Sci, Autophagy Res Ctr, Sch Med, Dept Clin Biochem, Shiraz, Iran.
C3 Shahid Sadoughi University of Medical Sciences; Tarbiat Modares
   University; Isfahan University of Medical Sciences; Shiraz University of
   Medical Science; Shiraz University of Medical Science
RP Vakili, O (corresponding author), Isfahan Univ Med Sci, Dept Clin Biochem, Sch Pharm & Pharmaceut Sci, Esfahan, Iran.; Vakili, O; Shafiee, SM (corresponding author), Shiraz Univ Med Sci, Autophagy Res Ctr, Sch Med, Dept Clin Biochem, Shiraz, Iran.
EM omidvakili@pharm.mui.ac.ir; shafieem@sums.ac.ir
RI Vakili, Omid/AAV-8676-2021; Borji, Mohammad/IAP-2940-2023; Khoshdel,
   Zahra/O-4352-2019; Maleki, Mohammad/KMY-6260-2024
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NR 208
TC 16
Z9 17
U1 8
U2 19
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0026-0495
EI 1532-8600
J9 METABOLISM
JI Metab.-Clin. Exp.
PD MAY
PY 2024
VL 154
AR 155811
DI 10.1016/j.metabol.2024.155811
EA MAR 2024
PG 16
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA NU6U9
UT WOS:001203015500001
PM 38309690
DA 2025-06-11
ER

PT J
AU Rocha, HNM
   Batista, GMS
   Storch, AS
   Garcia, VP
   Teixeira, GF
   Mentzinger, J
   Gomes, EAC
   Campos, MO
   Nóbrega, ACL
   Rocha, NG
AF Rocha, H. N. M.
   Batista, G. M. S.
   Storch, A. S.
   Garcia, V. P.
   Teixeira, G. F.
   Mentzinger, J.
   Gomes, E. A. C.
   Campos, M. O.
   Nobrega, A. C. L.
   Rocha, N. G.
TI Mental stress induces endothelial dysfunction by AT1R-mediated redox
   imbalance in overweight/obese men
SO BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
LA English
DT Article
DE Mental stress; Endothelial function; Oxidative stress; Angiotensin II;
   Ascorbic acid; Obesity
ID FLOW-MEDIATED DILATION; VITAMIN-C; AEROBIC EXERCISE; METABOLIC SYNDROME;
   RECEPTOR BLOCKER; BLOOD-PRESSURE; ANGIOTENSIN; OBESITY; VASODILATATION;
   RESPONSES
AB The main goal of this study was to determine whether oxidative imbalance mediated by AT1 receptor (AT1R) is responsible for deleterious endothelial responses to mental stress (MS) in overweight/obese class I men. Fifteen overweight/obese men (27 +/- 7 years old; 29.8 +/- 2.6 kg/m2) participated in three randomized experimental sessions with oral administration of the AT1R blocker olmesartan (40 mg; AT1R blockade) or ascorbic acid (AA; 3g) infusion or placebo [both intravenously (0.9% NaCl) and orally]. After two hours, endothelial function was determined by flow-mediated dilation (FMD) before (baseline), 30 min (30MS), and 60 min (60MS) after a five-minute acute MS session (Stroop Color Word Test). Blood was collected before (baseline), during MS, and 60 min after MS for redox homeostasis profiling: lipid peroxidation (TBARS; thiobarbituric acid reactive species), protein carbonylation, and catalase activity by colorimetry and superoxide dismutase (SOD) activity by an ELISA kit. At the placebo session, FMD significantly decreased 30MS (P=0.05). When compared to baseline, TBARS (P<0.02), protein carbonylation (P<0.01), catalase (P<0.01), and SOD (P<0.01) increased during the placebo session. During AT1R blockade, FMD increased 30 min after MS (P=0.01 vs baseline; P<0.01 vs placebo), while AA infusion increased FMD only 60 min after MS. No differences were observed during MS with the AT1R blockade and AA regarding TBARS, protein carbonylation, catalase, and SOD. AT1R-mediated redox imbalances played an important role in endothelial dysfunction to mental stress.
C1 [Rocha, H. N. M.; Batista, G. M. S.; Storch, A. S.; Garcia, V. P.; Teixeira, G. F.; Mentzinger, J.; Gomes, E. A. C.; Campos, M. O.; Rocha, N. G.] Univ Fed Fluminense, Dept Fisiol & Farmacol, Lab Ciencias Exercicio, Niteroi, RJ, Brazil.
   [Rocha, H. N. M.; Batista, G. M. S.; Storch, A. S.; Garcia, V. P.; Teixeira, G. F.; Mentzinger, J.; Gomes, E. A. C.; Rocha, N. G.] Univ Fed Fluminense, Inst Nacl Ciencia & Tecnol In Atividade Fis & Exe, Conselho Nacl Desenvolvimento Cient & Tecnol, Niteroi, RJ, Brazil.
C3 Universidade Federal Fluminense; Universidade Federal Fluminense
RP Rocha, NG (corresponding author), Univ Fed Fluminense, Dept Fisiol & Farmacol, Lab Ciencias Exercicio, Niteroi, RJ, Brazil.; Rocha, NG (corresponding author), Univ Fed Fluminense, Inst Nacl Ciencia & Tecnol In Atividade Fis & Exe, Conselho Nacl Desenvolvimento Cient & Tecnol, Niteroi, RJ, Brazil.
EM nataliagalito@id.uff.br
RI da Nobrega, Antonio/O-5107-2019; Rocha, Helena/AAO-9239-2020; Rocha,
   Helena/B-9530-2018; Rocha, Natalia Galito/AAN-7903-2020
OI Gomes, Erika/0000-0002-3150-1612; Rocha, Helena/0000-0002-4741-7343;
   Rocha, Natalia Galito/0000-0002-1990-9834; Mentzinger,
   Juliana/0000-0003-0999-2192; Fernandes Teixeira,
   Gabriel/0000-0002-7078-1880; Batista, Gabriel/0000-0002-1542-5242;
   Campos, Monique Opuszcka/0000-0001-9526-0937
FU Laboratory of Exercise Sciences at Fluminense Federal University;
   Brazilian National Council of Scientific and Technological Development
   (CNPq) [462265/2014-5]; Research Support Foundation of Rio de Janeiro
   (FAPERJ) [E-26/111.339/2014, E-26/110.641/2012]; Coordination for the
   Improvement of Higher Education Personnel (CAPES) [001]
FX The authors appreciate the time and effort expended by all volunteer
   subjects in this study. We also thank the staff and students from the
   Laboratory of Exercise Sciences at Fluminense Federal University. All
   the experiments were performed in the Laboratory of Exercise Sciences,
   located at the Department of Physiology and Pharmacology, Biomedical
   Institute, Fluminense Federal University. This work was supported by
   grants from the Brazilian National Council of Scientific and
   Technological Development (CNPq, grant 462265/2014-5) , the Research
   Support Foundation of Rio de Janeiro (FAPERJ, grants E-26/111.339/2014
   and E-26/110.641/2012) , and Coordination for the Improvement of Higher
   Education Personnel (CAPES, scholarship, Finance Code 001).
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NR 39
TC 1
Z9 2
U1 0
U2 0
PU ASSOC BRAS DIVULG CIENTIFICA
PI RIBEIRAO PRETO
PA FACULDADE MEDICINA, CASA 10, 14049 RIBEIRAO PRETO, RIBEIRAO PRETO, SP
   14049, BRAZIL
SN 0100-879X
EI 1414-431X
J9 BRAZ J MED BIOL RES
JI Brazilian J. Med. Biol. Res.
PY 2023
VL 56
AR e12547
DI 10.1590/1414-431X2023e12547
PG 10
WC Biology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics; Research & Experimental
   Medicine
GA C4TR9
UT WOS:000961862400001
PM 36995873
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Cha, JY
   Park, JM
   Lee, HJ
   Bae, JS
   Han, YM
   Oh, BC
   Ko, KH
   Hahm, KB
AF Cha, Ji-Young
   Park, Jong-Min
   Lee, Ho-Jae
   Bae, Jin-Sik
   Han, Young-Min
   Oh, Byung-Chul
   Ko, Kwang Hyun
   Hahm, Ki-Baik
TI Emerging Targets to Relieve Fat Stress-Induced Liver Diseases: UDCA,
   Tocotrienol, ω-3 PUFAs, and IgY Targeted NPC1L1 Cholesterol Transporter
SO CURRENT PHARMACEUTICAL DESIGN
LA English
DT Review
DE Non-alcoholic fatty liver disease; non-alcoholic steatohepatitis; liver
   fibrosis; pharmacological therapy; tocotrienol; ursodeoxycholic acid;
   IgY targeted NPC1L1; fatty acids
ID HELICOBACTER-PYLORI INFECTION; UREASE IMMUNOGLOBULIN-Y; EGG-YOLK
   ANTIBODIES; NF-KAPPA-B; VITAMIN-E; URSODEOXYCHOLIC ACID;
   GAMMA-TOCOTRIENOL; NONALCOHOLIC STEATOHEPATITIS; MITOCHONDRIAL
   DYSFUNCTION; HEPATOCELLULAR-CARCINOMA
AB Fat stress-induced liver disease is a hepatic manifestation of metabolic syndrome initiated by excess fat accumulation and encompasses a wide spectrum of diseases from non-alcoholic fatty liver disease to nonalcoholic steatohepatitis, a precursor lesion progressing to more aggressive liver cirrhosis and hepatocellular carcinoma. Although the incidence of these fat stress-induced liver diseases is rapidly increasing worldwide in parallel with the growing epidemics of obesity and metabolic diseases, its exact pathogenesis is not well defined. Although obesity, sedentary life-style, altered dietary pattern, insulin resistance, altered intestinal barrier function, inflammatory cytokines, and oxidative stress have been acknowledged as contributing factors because of the indefinite pathogenesis of metabolic diseases, the only reliable treatment is lifestyle intervention composed of restrictive diet and exercise. Additionally, some existing medications such as pioglitazone and antioxidants such as vitamin E were reported to be effective; in this review, several novel agents especifically targeting nonalcoholic fatty liver disease pathogenesis under clinical trial will be introduced. These include an NPC1L1 blocker (ezetimibe), which significantly improved histological and symptomatic scores associated with steatohepatitis and fibrosis; clofibrate, phentoxyfylline, ursodeoxycholic acid, and tocopherol, all of which are prescribed to relieve fat stress; and additional IgY targeted NPC1L1, tocotrienol, ursodeoxycholic acid, and omega-3 polyunsaturated fatty acids, which are actively under investigation to confirm the safety of long- term use.
C1 [Cha, Ji-Young; Lee, Ho-Jae; Bae, Jin-Sik; Oh, Byung-Chul] Gachon Univ, Lee Gil Ya Canc & Diabet Inst, Dept Biochem, Incheon, South Korea.
   [Cha, Ji-Young] Gil Hosp, Gachon Med Res Inst, Incheon, South Korea.
   [Park, Jong-Min; Han, Young-Min; Hahm, Ki-Baik] CHA Univ, CHA Canc Prevent Res Ctr, CHA Bio Complex, Seongnam, South Korea.
   [Ko, Kwang Hyun] CHA Univ, Bundang Med Ctr, Digest Dis Ctr, Seongnam, South Korea.
   CHA Univ, Bundang Med Ctr, Seongnam 463838, South Korea.
C3 Gachon University; Pochon Cha University; Pochon Cha University; Pochon
   Cha University
RP Hahm, KB (corresponding author), CHA Canc Prevent Res Ctr, CHA Bio Complex, Seongnam 463838, South Korea.
EM hahmkb@cha.ac.kr
OI Oh, Byung-Chul/0000-0002-4277-7083
FU Basic Science Research Program through National Research Foundation of
   Korea (NRF) - Ministry of Education, Science and Technology
   [NRF-2016R1A2B4015866]; Ministry of Food and Drug Safety [14182MFDS978];
   National Center of Efficacy Evaluation for the Development of Health
   Products Targeting Digestive Disorders (NCEED)
FX This work was supported by the Basic Science Research Program through
   the National Research Foundation of Korea (NRF) funded by the Ministry
   of Education, Science and Technology (NRF-2016R1A2B4015866), a grant
   (14182MFDS978) from Ministry of Food and Drug Safety in 2016 (to J-Y
   Cha), and the National Center of Efficacy Evaluation for the Development
   of Health Products Targeting Digestive Disorders (NCEED) (to K-B Hahm).
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NR 136
TC 4
Z9 4
U1 3
U2 20
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1381-6128
EI 1873-4286
J9 CURR PHARM DESIGN
JI Curr. Pharm. Design
PY 2017
VL 23
IS 27
BP 3941
EP 3951
DI 10.2174/1381612823666170714124824
PG 11
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA FL3SP
UT WOS:000414143700005
PM 28714405
DA 2025-06-11
ER

PT J
AU Mercau, ME
   Repetto, EM
   Perez, MN
   Calejman, CM
   Puch, SS
   Finkielstein, CV
   Cymeryng, CB
AF Mercau, Mara E.
   Repetto, Esteban M.
   Perez, Matas N.
   Martinez Calejman, Camila
   Sanchez Puch, Silvia
   Finkielstein, Carla V.
   Cymeryng, Cora B.
TI Moderate Exercise Prevents Functional Remodeling of the Anterior
   Pituitary Gland in Diet-Induced Insulin Resistance in Rats: Role of
   Oxidative Stress and Autophagy
SO ENDOCRINOLOGY
LA English
DT Article
ID ENDOPLASMIC-RETICULUM STRESS; HIGH-FAT DIET; ADRENAL AXIS; MITOCHONDRIAL
   DYSFUNCTION; METABOLIC SYNDROME; BASAL ACTIVITY; ACIDS; OBESITY; MICE;
   ACCUMULATION
AB A sustained elevation of glucocorticoid production, associated with the establishment of insulin resistance (IR) could add to the deleterious effects of the IR state. The aim of this study is to analyze the consequences of long-term feeding with a sucrose-rich diet (SRD) on Pomc/ACTH production, define the underlying cellular processes, and determine the effects of moderate exercise (ME) on these parameters. Animals fed a standard chow with or without 30% sucrose in the drinking water were subjected to ME. Circulating hormone levels were determined, and pituitary tissues were processed and analyzed by immunobloting and quantitative real-time PCR. Parameters of oxidative stress (OxS), endoplasmic reticulum stress, and autophagy were also determined. Rats fed SRD developed a decrease in pituitary Pomc/ACTH expression levels, increased expression of antioxidant enzymes, and induction of endoplasmic reticulum stress and autophagy. ME prevented pituitary dysfunction as well as induction of antioxidant enzymes and autophagy. Reporter assays were performed in AtT-20 corticotroph cells incubated in the presence of palmitic acid. Pomc transcription was inhibited by palmitic acid-dependent induction of OxS and autophagy, as judged by the effect of activators and inhibitors of both processes. Long-term feeding with SRD triggers the generation of OxS and autophagy in the pituitary gland, which could lead to a decline in Pomc/ACTH/glucocorticoid production. These effects could be attributed to an increase in fatty acids availability to the pituitary gland. ME was able to prevent these alterations, suggesting additional beneficial effects of ME as a therapeutic strategy in the management of IR.
C1 [Mercau, Mara E.; Repetto, Esteban M.; Perez, Matas N.; Martinez Calejman, Camila; Sanchez Puch, Silvia; Cymeryng, Cora B.] Univ Buenos Aires, Fac Med, Consejo Nacl Invest Cient & Tecn, Dept Bioquim Humana,Ctr Estudios Farmacol & Bot, C1121ABG, Buenos Aires, DF, Argentina.
   [Mercau, Mara E.; Finkielstein, Carla V.] Virginia Tech, Dept Biol Sci, Integrated Cellular Responses Lab, Blacksburg, VA 24061 USA.
   Virginia Tech, Virginia Bioinformat Inst, Blacksburg, VA 24061 USA.
C3 University of Buenos Aires; Consejo Nacional de Investigaciones
   Cientificas y Tecnicas (CONICET); Virginia Polytechnic Institute & State
   University; Virginia Polytechnic Institute & State University
RP Cymeryng, CB (corresponding author), Univ Buenos Aires, Fac Med, Dept Bioquim Humana, Paraguay 2155,5 Piso,C1121 ABG, Buenos Aires, DF, Argentina.
EM cymeryng@fmed.uba.ar
OI Mercau, Maria E/0000-0001-6971-8676; finkielstein,
   carla/0000-0002-8417-4643; Repetto, Esteban/0000-0001-6536-7370
FU Agencia Nacional de Promocion de Ciencia y Tecnologia Grant ANPCyT PICT
   [1034]; Consejo Nacional de Investigaciones Cientificas y Tecnicas Grant
   CONICET PIP [11220120100257]; Universidad de Buenos Aires Grant UBACyT
   [20020130100115BA]; National Sciences Foundation [MCB-1517298]; Div Of
   Molecular and Cellular Bioscience; Direct For Biological Sciences
   [1517298] Funding Source: National Science Foundation
FX This work was supported by the Agencia Nacional de Promocion de Ciencia
   y Tecnologia Grant ANPCyT PICT 2008 No1034, the Consejo Nacional de
   Investigaciones Cientificas y Tecnicas Grant CONICET PIP 11220120100257,
   the Universidad de Buenos Aires Grant UBACyT 20020130100115BA (to
   C.B.C.), and the National Sciences Foundation Grant MCB-1517298 (to
   C.V.F.).
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NR 45
TC 12
Z9 13
U1 0
U2 6
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0013-7227
EI 1945-7170
J9 ENDOCRINOLOGY
JI Endocrinology
PD MAR
PY 2016
VL 157
IS 3
BP 1135
EP 1145
DI 10.1210/en.2015-1777
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA DK0CC
UT WOS:000374579000016
PM 26672805
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Snow, SJ
   Henriquez, AR
   Costa, DL
   Kodavanti, UP
AF Snow, Samantha J.
   Henriquez, Andres R.
   Costa, Daniel L.
   Kodavanti, Urmila P.
TI Neuroendocrine Regulation of Air Pollution Health Effects: Emerging
   Insights
SO TOXICOLOGICAL SCIENCES
LA English
DT Review
DE air pollution; neuroendocrine; hypothalamus; autonomic; stress hormones;
   ozone
ID PARTICULATE MATTER EXPOSURE; EPISODIC OZONE EXPOSURE; INDUCED LUNG
   INJURY; LONG-TERM EXPOSURE; HEART-RATE; INSULIN-RESISTANCE; DIESEL
   EXHAUST; AMBIENT POLLUTION; STRESS HORMONES; INHALATION
AB Air pollutant exposures are linked to cardiopulmonary diseases, diabetes, metabolic syndrome, neurobehavioral conditions, and reproductive abnormalities. Significant effort is invested in understanding how pollutants encountered by the lung might induce effects in distant organs. The role of circulating mediators has been predicted; however, their origin and identity have not been confirmed. New evidence has emerged which implicates the role of neuroendocrine sympathetic-adrenal-medullary (SAM) and hypothalamic-pituitary-adrenal (HPA) stress axes in mediating a wide array of systemic and pulmonary effects. Our recent studies using ozone exposure as a prototypical air pollutant demonstrate that increases in circulating adrenal-derived stress hormones (epinephrine and cortisol/corticosterone) contribute to lung injury/inflammation and metabolic effects in the liver, pancreas, adipose, and muscle tissues. When stress hormones are depleted by adrenalectomy in rats, most ozone effects including lung injury/inflammation are diminished. Animals treated with antagonists for adrenergic and glucocorticoid receptors show inhibition of the pulmonary and systemic effects of ozone, whereas treatment with agonists restore and exacerbate the ozone-induced injury/inflammation phenotype, implying the role of neuroendocrine activation. The neuroendocrine system is critical for normal homeostasis and allostatic activation; however, chronic exposure to stressors may lead to increases in allostatic load. The emerging mechanisms by which circulating mediators are released and are responsible for producing multiorgan effects of air pollutants insists upon a paradigm shift in the field of air pollution and health. Moreover, since these neuroendocrine responses are linked to both chemical and nonchemical stressors, the interactive influence of air pollutants, lifestyle, and environmental factors requires further study.
C1 [Snow, Samantha J.; Kodavanti, Urmila P.] US EPA, Environm Publ Hlth Div, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA.
   [Henriquez, Andres R.] Oak Ridge Inst Sci & Educ, Res Triangle Pk, NC 27711 USA.
   [Costa, Daniel L.] US EPA, Res Triangle Pk, NC 27711 USA.
C3 United States Environmental Protection Agency; Oak Ridge Associated
   Universities; United States Department of Energy (DOE); Oak Ridge
   Institute for Science & Education; United States Environmental
   Protection Agency
RP Kodavanti, UP (corresponding author), US EPA, Environm Publ Hlth Div, 109 TW Alexander Dr,Room B564, Res Triangle Pk, NC 27711 USA.
EM kodavanti.urmila@epa.gov
RI Costa, Daniel/KJK-3910-2024; Henriquez, Andres/AAQ-6113-2021; Snow,
   Samantha/E-2614-2013
OI Henriquez, Andres/0000-0002-1917-4153; Hodge, Myles/0000-0002-6556-7097;
   Snow, Samantha/0000-0003-1812-8582
FU Oak Ridge Institute for Science and Education; EPA Co-Operative
   agreement
FX The authors thank Drs Michael Madden, Andrew Ghio, and Ian Gilmour of
   the US EPA for their critical review of the manuscript. This work was
   supported by Oak Ridge Institute for Science and Education and EPA
   Co-Operative agreement (A.R.H.).
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NR 113
TC 82
Z9 85
U1 0
U2 17
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1096-6080
EI 1096-0929
J9 TOXICOL SCI
JI Toxicol. Sci.
PD JUL
PY 2018
VL 164
IS 1
BP 9
EP 20
DI 10.1093/toxsci/kfy129
PG 12
WC Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Toxicology
GA JX5XQ
UT WOS:000503807900001
PM 29846720
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Bouderba, S
   Sanchez-Martin, C
   Villanueva, GR
   Detaille, D
   Koceïr, EA
AF Bouderba, Saida
   Sanchez-Martin, Carlos
   Villanueva, Gloria R.
   Detaille, Dominique
   Koceir, E. Ahmed
TI Beneficial effects of silibinin against the progression of metabolic
   syndrome, increased oxidative stress, and liver steatosis in
   Psammomys obesus, a relevant animal model of human obesity and
   diabetes
SO JOURNAL OF DIABETES
LA English
DT Article
DE antioxidant systems; dyslipidemia; hepatic insulin resistance; Psammomys
   obesus; silibinin; Type 2 diabetes
ID PERIFUSED RAT HEPATOCYTES; INSULIN-RESISTANCE; FATTY LIVER;
   SUPEROXIDE-DISMUTASE; SILYBUM-MARIANUM; SILYMARIN; HYPERGLYCEMIA;
   DISEASE; HYPERINSULINEMIA; EXCRETION
AB BackgroundInsulin resistance and oxidative stress are major pathogenic mechanisms leading to chronic liver diseases in diabetic subjects. The gerbil Psammomys obesus is a unique model of nutritional diabetes resembling the disease in humans. This study investigated whether the natural ingredient silibinin, known as hepatoprotective, could decrease oxidative stress and reduce liver damage in obese gerbils.
   MethodsControl animals were fed their vegetable-based low caloric diet while two other rat groups ingested a high calorie diet for 14 weeks. Silibinin, or its vehicle, was administrated by gastric intubation (100mg/kg per day) from the 7th week of treatment, which corresponds to an established insulin resistance state. At the end of the experiments, the hepatic biochemical profile, markers of oxidative stress in either plasma or liver tissue, and histological alterations were examined.
   ResultsDiabetic P.obesus displayed many metabolic disturbances (hyperinsulinemia, hyperglycemia, dyslipidemia), which were aggravated for the last 8 weeks. These events were coupled with greater oxidative stress (decline in glutathione, rise in lipoperoxidation). In addition, glutathione peroxidase activity was reduced while the level of superoxide dismutase was elevated. Interestingly, treatment with silibinin alleviated most of the metabolic defects, especially high triglyceride levels, reduced insulin resistance and largely restored antioxidant status. Also, Masson's trichrome staining revealed distinct steatosis, yet silibinin partially reversed this manifestation.
   ConclusionSilibinin affords substantial protection against the progression of insulin resistance in Type 2 diabetes mellitus for P.obesus by hampering the oxidative process and improving hepatic metabolism.
C1 [Bouderba, Saida; Koceir, E. Ahmed] Univ Sci & Technol Houari Boumediene USTHB, Dept Biol Sci & Physiol, Lab Bioenerget & Intermediary Metab, Algiers, Algeria.
   [Sanchez-Martin, Carlos; Villanueva, Gloria R.] Univ Salamanca, Fac Pharm, Dept Physiol & Pharmacol, E-37008 Salamanca, Spain.
   [Detaille, Dominique] Univ Bordeaux, Rhythmol & Heart Modeling Inst LIRYC, Bordeaux, France.
   [Detaille, Dominique] INSERM, U1045, Cardiothorac Res Ctr CRCTB, F-33604 Pessac, France.
C3 University Science & Technology Houari Boumediene; University of
   Salamanca; Universite de Bordeaux; Institut National de la Sante et de
   la Recherche Medicale (Inserm); Universite de Bordeaux
RP Detaille, D (corresponding author), INSERM, U1045, Ctr Rech Cardiothorac Bordeaux CRCTB, Campus Xavier Arnozan PTIB,Ave Haut Leveque, F-33604 Pessac, France.
EM dominique.detaille@inserm.fr
RI Sanchez-Martin, Carlos/AAL-3343-2020
OI Sanchez Martin, Carlos/0000-0001-5223-4798; KOCEIR,
   Elhadj-Ahmed/0000-0003-1345-2535
FU National Research Program (PNR) [208/ANDRS/2011]; National
   Administration of Algerian Higher Education and Scientific Research
   (DG-RSDT); Program of Interuniversity Cooperation (PCI) [A/026422/09]
FX This work was supported by grants from the National Research Program
   (PNR no208/ANDRS/2011), the National Administration of Algerian Higher
   Education and Scientific Research (DG-RSDT) and the Program of
   Interuniversity Cooperation (PCI; grant noA/026422/09).
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NR 45
TC 39
Z9 41
U1 0
U2 18
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1753-0393
EI 1753-0407
J9 J DIABETES
JI J. Diabetes
PD MAR
PY 2014
VL 6
IS 2
BP 184
EP 192
DI 10.1111/1753-0407.12083
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA AA7AA
UT WOS:000331248200014
PM 23953934
DA 2025-06-11
ER

PT J
AU Kajantie, E
   Phillips, DIW
AF Kajantie, E
   Phillips, DIW
TI The effects of sex and hormonal status on the physiological response to
   acute psychosocial stress
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Review
DE sex difference; sex; gender; programming; estrogen; stress; cortisol
ID PITUITARY-ADRENAL AXIS; LOW-BIRTH-WEIGHT; CORTICOTROPIN-RELEASING
   HORMONE; MESSENGER-RIBONUCLEIC-ACID; 11-BETA-HYDROXYSTEROID
   DEHYDROGENASE TYPE-2; INFLAMMATORY CYTOKINE PRODUCTION; INTRAUTERINE
   GROWTH RESTRICTION; PLASMA-CORTISOL CONCENTRATIONS; INSULIN-RESISTANCE
   SYNDROME; MENSTRUAL-CYCLE PHASE
AB Whether one is mate or female is one of the most important determinants of human health. While males are more susceptible to cardiovascular and infectious disease, they are outnumbered by women for many autoimmune disorders, fibromyalgia and chronic pain. Recently, individual differences in the physiological response to stress have emerged as a potentially important risk factor for these disorders. This raises the possibility that sex differences in prevalence of disease could at Least in part be explained by sex differences in the nature of the physiological response to stress.
   In a psychophysiological laboratory, the autonomic nervous system response can be provoked by many different stressors including physical, mental and psychosocial tasks, while the hypothalamic-pituitary-adrenal axis (HPAA) response seems to be more specific to a psychosocial challenge incorporating ego involvement. The responses of both systems to different psychosocial challenges have been subject to extensive research, although in respect of sex differences the HPAA response has probably been more systematically studied. In this review, we focus on sex differences in HPAA and autonomic nervous system responses to acute psychosocial stress. Although some differences are dependent on the stressor used, the responses of both systems show marked and consistent differences according to sex, with the phase of the menstrual cycle, menopausal status and pregnancy having marked effects. Between puberty and menopause, adult women usually show tower HPAA and autonomic responses than men of same age. However, the HPAA response is higher in the luteal phase, when for example poststress free cortisol. levels approach those of men. After menopause, there is an increase in sympathoadrenal responsiveness, which is attenuated during oral hormone replacement therapy, with most evidence suggesting that HPAA activity shows the same trends. Interestingly, pregnancy is associated with an attenuated response of the sympathoadrenal and HPAA systems at least as assessed by biochemical stimulation.
   It is likely that these sex differences in autonomic function are a result of estrogen exposure which attenuates sympathoadrenal responsiveness. The HPAA is however somewhat more complex and evidence now suggests the influence of other modifiers such as arginine vasopressin (AVP) and the regulation of circulating cortisol bioavailability by corticosteroid-binding globulin (CBG).
   The pronounced and multi-faceted sex differences in stress responsiveness suggest that they are a product of a strong evolutionary pressure. We hypothesise that this has to a great deal been driven by the need to protect the fetus from the adverse effects of maternal stress responses, in particular excess glucocorticoid exposure. Studying this hypothesis may have a fundamental impact on our understanding about how adult health is set during early life and how adult disease could be prevented in men and women. (c) 2005 Elsevier Ltd. All rights reserved.
C1 Natl Publ Hlth Inst, Dept Epidemiol & Hlth Promot, Helsinki 00300, Finland.
   Univ Southampton, MRC Epidemiol Resource Ctr, Southampton S016 6YD, Hants, England.
   Univ Southampton, Dev Origins Adult Health & Dis Ctr, Southampton S016 6YD, Hants, England.
   Univ Helsinki, Cent Hosp, Hosp Children & Adolescents, Helsinki, Finland.
C3 Finland National Institute for Health & Welfare; University of
   Southampton; University of Southampton; University of Helsinki; Helsinki
   University Central Hospital
RP Kajantie, E (corresponding author), Natl Publ Hlth Inst, Dept Epidemiol & Hlth Promot, Mannerheimintie 166, Helsinki 00300, Finland.
EM eero.kajantie@helsinki.fi
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NR 162
TC 741
Z9 839
U1 2
U2 135
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD FEB
PY 2006
VL 31
IS 2
BP 151
EP 178
DI 10.1016/j.psyneuen.2005.07.002
PG 28
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA 006FL
UT WOS:000234881500001
PM 16139959
DA 2025-06-11
ER

PT J
AU Sessions-Bresnahan, DR
   Heuberger, AL
   Carnevale, EM
AF Sessions-Bresnahan, Dawn R.
   Heuberger, Adam L.
   Carnevale, Elaine M.
TI Obesity in mares promotes uterine inflammation and alters embryo lipid
   fingerprints and homeostasis
SO BIOLOGY OF REPRODUCTION
LA English
DT Article
DE equids; embryo; obesity; lipids; insulin; leptin; adiponectin;
   metabolomics; uterus
ID TUMOR-NECROSIS-FACTOR; FATTY-ACID; MATERNAL OBESITY; INSULIN
   SENSITIVITY; PREGNANT-WOMEN; IN-VITRO; EXPRESSION; CELL; STRESS;
   CYTOKINES
AB Maternal body composition can be an important determinant for development of obesity and metabolic syndrome in adult offspring. Obesity-related outcomes in offspring may include epigenetic alterations; however, mechanisms of fetal programming remain to be fully elucidated. This study was conducted to determine the impact of maternal obesity in the absence of a high fat diet on equine endometrium and preimplantation embryos. Embryos were collected from normal and obese mares at 8 and 16 days and a uterine biopsy at 16 days (0 day = ovulation). With the exception of 8 day embryos, each sample was divided into two pieces. One piece was analyzed for gene expression markers related to carbohydrate metabolism, lipid homeostasis, inflammation, endoplasmic reticulum stress, oxidative stress, mitochondrial stress, and components of the insulin-like growth factor (IGF) system. The second piece was analyzed for lipid content using matrix-assisted laser desorption/ionization mass spectrometry. Obese mares had elevated concentrations of insulin, leptin, and total cholesterol, and they tended to have increased triglycerides and decreased insulin sensitivity. Embryos from obese mares had altered transcript abundance in genes for inflammation and lipid homeostasis, as well as endoplasmic reticulum, oxidative and mitochondrial stress and altered lipid fingerprints. Endometrium from obese mares had increased expression of inflammatory cytokines, lipid homeostasis regulation, mitochondrial stress, and the IGF2 system. This study demonstrates that increased adiposity in mares alters the uterine environment, transcript abundance of genes for cellular functions, and lipid profiles of embryos. These alterations could affect prenatal programming, with potential long-term effects in offspring.
   Summary Sentence
   Excess adiposity is sufficient to increase transcript abundance of inflammatory cytokines in the uterine endometrium and alters embryonic lipid content, and gene expression for lipid metabolism, endoplasmic reticulum stress, and mitochondrial function.
C1 [Sessions-Bresnahan, Dawn R.] Dept Anim Sci, Mt Berry, GA USA.
   [Sessions-Bresnahan, Dawn R.; Carnevale, Elaine M.] Colorado State Univ, Biomed Sci, Ft Collins, CO 80523 USA.
   [Heuberger, Adam L.] Colorado State Univ, Hort & Landscape Architecture, Ft Collins, CO 80523 USA.
   [Heuberger, Adam L.] Colorado State Univ, Prote & Metabol Facil, Ft Collins, CO 80523 USA.
C3 Colorado State University System; Colorado State University Fort
   Collins; Colorado State University System; Colorado State University
   Fort Collins; Colorado State University System; Colorado State
   University Fort Collins
RP Carnevale, EM (corresponding author), Colorado State Univ, Equine Reprod Lab, Biomed Sci, Campus Delivery 1693, Ft Collins, CO 80521 USA.
EM elaine.carnevale@colostate.edu
RI Bresnahan, Dawn/H-2881-2019
OI Bresnahan, Dawn/0000-0003-1032-8846
FU Cecil and Irene Hylton Foundation; Colorado State University Equine
   Reproduction Laboratory Assisted Reproduction Program; College Research
   Council at Colorado State University
FX This work is supported by the Cecil and Irene Hylton Foundation, the
   Colorado State University Equine Reproduction Laboratory Assisted
   Reproduction Program, and the College Research Council at Colorado State
   University.
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NR 69
TC 26
Z9 28
U1 1
U2 10
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0006-3363
EI 1529-7268
J9 BIOL REPROD
JI Biol. Reprod.
PD OCT
PY 2018
VL 99
IS 4
BP 761
EP 772
DI 10.1093/biolre/ioy107
PG 12
WC Reproductive Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Reproductive Biology
GA HG7IQ
UT WOS:000455164700012
PM 29741587
DA 2025-06-11
ER

PT J
AU Seidita, A
   Cusimano, A
   Giuliano, A
   Meli, M
   Carroccio, A
   Soresi, M
   Giannitrapani, L
AF Seidita, Aurelio
   Cusimano, Alessandra
   Giuliano, Alessandra
   Meli, Maria
   Carroccio, Antonio
   Soresi, Maurizio
   Giannitrapani, Lydia
TI Oxidative Stress as a Target for Non-Pharmacological Intervention in
   MAFLD: Could There Be a Role for EVOO?
SO ANTIOXIDANTS
LA English
DT Review
DE ROS; oxidative stress; MAFLD; MD; EVOO
ID NONALCOHOLIC FATTY LIVER; VIRGIN OLIVE OIL; MEDITERRANEAN-STYLE DIET;
   VITAMIN-E TREATMENT; AMINOTRANSFERASE LEVELS; METABOLIC SYNDROME;
   ENDOTHELIAL DYSFUNCTION; URSODEOXYCHOLIC ACID; INSULIN-RESISTANCE;
   PRESCRIPTIVE DIET
AB Oxidative stress plays a central role in most chronic liver diseases and, in particular, in metabolic dysfunction-associated fatty liver disease (MAFLD), the new definition of an old condition known as non-alcoholic fatty liver disease (NAFLD). The mechanisms leading to hepatocellular fat accumulation in genetically predisposed individuals who adopt a sedentary lifestyle and consume an obesogenic diet progress through mitochondrial and endoplasmic reticulum dysfunction, which amplifies reactive oxygen species (ROS) production, lipid peroxidation, malondialdehyde (MDA) formation, and influence the release of chronic inflammation and liver damage biomarkers, such as pro-inflammatory cytokines. This close pathogenetic link has been a key stimulus in the search for therapeutic approaches targeting oxidative stress to treat steatosis, and a number of clinical trials have been conducted to date on subjects with NAFLD using drugs as well as supplements or nutraceutical products. Vitamin E, Vitamin D, and Silybin are the most studied substances, but several non-pharmacological approaches have also been explored, especially lifestyle and diet modifications. Among the dietary approaches, the Mediterranean Diet (MD) seems to be the most reliable for affecting liver steatosis, probably with the added value of the presence of extra virgin olive oil (EVOO), a healthy food with a high content of monounsaturated fatty acids, especially oleic acid, and variable concentrations of phenols (oleocanthal) and phenolic alcohols, such as hydroxytyrosol (HT) and tyrosol (Tyr). In this review, we focus on non-pharmacological interventions in MAFLD treatment that target oxidative stress and, in particular, on the role of EVOO as one of the main antioxidant components of the MD.
C1 [Seidita, Aurelio; Giuliano, Alessandra; Meli, Maria; Carroccio, Antonio] Univ Palermo, V Cervello Hosp, Dept Hlth Promot Sci, Unit Internal Med,Osped Riuniti Villa Sofia Cervel, I-90146 Palermo, Italy.
   [Seidita, Aurelio; Cusimano, Alessandra; Giannitrapani, Lydia] Natl Res Council CNR, Inst Biomed Res & Innovat IRIB, I-90146 Palermo, Italy.
   [Soresi, Maurizio; Giannitrapani, Lydia] Univ Palermo, Univ Hosp P Giaccone, Dept Hlth Promot Sci Maternal & Infant Care, Unit Internal Med, I-90127 Palermo, Italy.
C3 University of Palermo; Consiglio Nazionale delle Ricerche (CNR);
   Istituto Ricerca l'Innovazione Biomedica (IRIB-CNR); University of
   Palermo; Policlinico Paolo Giaccone
RP Giannitrapani, L (corresponding author), Natl Res Council CNR, Inst Biomed Res & Innovat IRIB, I-90146 Palermo, Italy.; Giannitrapani, L (corresponding author), Univ Palermo, Univ Hosp P Giaccone, Dept Hlth Promot Sci Maternal & Infant Care, Unit Internal Med, I-90127 Palermo, Italy.
EM aurelio.seidita@unipa.it; alessandra.cusimano01@unipa.it;
   alegiuliano94@gmail.com; maria.meli@unipa.it;
   antonio.carroccio@unipa.it; maurizio.soresi@unipa.it;
   lydia.giannitrapani@unipa.it
RI ; Seidita, Aurelio/IQT-5629-2023
OI Cusimano, Alessandra/0000-0002-3595-8898; Giannitrapani,
   Lydia/0000-0003-2845-5296; Giuliano, Alessandra/0000-0002-9423-5462;
   Soresi, Maurizio/0000-0001-7850-555X; Seidita,
   Aurelio/0000-0003-4080-2641
FU European Union-PON Research and Innovation 2014-2020 [DM1062/2021]
FX This research was co-financed by the European Union-PON Research and
   Innovation 2014-2020-DM1062/2021. The funder had no role in the design
   of the study; in the collection, analyses, or interpretation of data; in
   the writing of the manuscript; or in the decision to publish the
   results.
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NR 180
TC 8
Z9 8
U1 4
U2 7
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD JUN
PY 2024
VL 13
IS 6
AR 731
DI 10.3390/antiox13060731
PG 29
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA WJ8V9
UT WOS:001254603700001
PM 38929170
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Petek, TH
   Petek, T
   Mocnik, M
   Varda, NM
AF Hertis Petek, Tjasa
   Petek, Tadej
   Mocnik, Mirjam
   Marcun Varda, Natasa
TI Systemic Inflammation, Oxidative Stress and Cardiovascular Health in
   Children and Adolescents: A Systematic Review
SO ANTIOXIDANTS
LA English
DT Review
DE oxidative stress; systemic inflammation; cardiovascular health;
   endothelial dysfunction; biomarkers; children and adolescents;
   antioxidants; exercise; diet; chronic disease
ID INTIMA-MEDIA THICKNESS; LOW-GRADE INFLAMMATION; DYNAMIC THIOL/DISULPHIDE
   HOMEOSTASIS; TYPE-1 DIABETES-MELLITUS; C-REACTIVE PROTEIN; ORAL
   L-ARGININE; OBESE CHILDREN; ENDOTHELIAL DYSFUNCTION; INSULIN-RESISTANCE;
   METABOLIC SYNDROME
AB Recent studies indicate that cerebrovascular diseases and processes of atherosclerosis originate in the childhood era and are largely influenced by chronic inflammation. Some features of vascular dysfunction in adulthood may even be programmed prenatally via genetic influences and an unfavorable intrauterine milieu. Oxidative stress, defined by an imbalance between the production and generation of reactive oxygen species (ROS) in cells and tissues and the capability of an organism to scavenge these molecules via antioxidant mechanisms, has been linked to adverse cardiovascular health in adults, yet has not been systematically reviewed in the pediatric population. We performed a systematic search as per the PRISMA guidelines in PubMed/Medline and Cochrane Reviews and detected, in total, 1228 potentially eligible pediatric articles on systemic inflammation, oxidative stress, antioxidant use, cardiovascular disease and endothelial dysfunction. The abstracts and full-text manuscripts of these were screened for inclusion and exclusion criteria, and a total of 160 articles were included. The results indicate that systemic inflammation and oxidative stress influence cardiovascular health in many chronic pediatric conditions, including hypertension, obesity, diabetes mellitus types 1 and 2, chronic kidney disease, hyperlipidemia and obstructive sleep apnea. Exercise and diet may diminish ROS formation and enhance the total serum antioxidant capacity. Antioxidant supplementation may, in selected conditions, contribute to the diminution of the oxidative state and improve endothelial function; yet, in many areas, studies provide unsatisfactory results.
C1 [Hertis Petek, Tjasa; Petek, Tadej; Mocnik, Mirjam; Marcun Varda, Natasa] Univ Med Ctr Maribor, Dept Paediat, Ljubljanska 5, Maribor 2000, Slovenia.
   [Hertis Petek, Tjasa; Petek, Tadej; Mocnik, Mirjam; Marcun Varda, Natasa] Univ Maribor, Fac Med, Taborska Ul 8, Maribor 2000, Slovenia.
C3 University of Maribor; University of Maribor
RP Petek, T (corresponding author), Univ Med Ctr Maribor, Dept Paediat, Ljubljanska 5, Maribor 2000, Slovenia.; Petek, T (corresponding author), Univ Maribor, Fac Med, Taborska Ul 8, Maribor 2000, Slovenia.
EM tjasa.hertispetek@ukc-mb.si; tadej.petek@ukc-mb.si;
   mirjam.mocnik@ukc-mb.si; natasa.marcunvarda@ukc-mb.si
RI Močnik, Mirjam/AAL-5221-2021; Petek, Tadej/HJP-0261-2023
OI Marcun Varda, Natasa/0000-0003-0634-3576; Petek,
   Tadej/0000-0001-9115-5398
FU University Medical Centre Maribor, Maribor, Slovenia
FX This research was funded with payment of APC by the University Medical
   Centre Maribor, 2000 Maribor, Slovenia.
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NR 187
TC 47
Z9 47
U1 1
U2 14
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD MAY
PY 2022
VL 11
IS 5
AR 894
DI 10.3390/antiox11050894
PG 42
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA 1Q0UJ
UT WOS:000802413700001
PM 35624760
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Wang, WJ
   Ren, H
   Tian, QY
   Tang, CL
   Meng, WJ
AF Wang, Wenjuan
   Ren, Hui
   Tian, Qiuye
   Tang, Chunling
   Meng, Wenjuan
TI Effects of Occupational Stress on Blood Lipids, Blood Sugar and Immune
   Function of Doctors
SO IRANIAN JOURNAL OF PUBLIC HEALTH
LA English
DT Article
DE Occupational stress; Blood lipids; Blood sugar; Immune function
ID EFFORT-REWARD IMBALANCE; JOB STRAIN; METABOLIC SYNDROME; RISK-FACTORS;
   MEN; OBESITY; WORK
AB Background: We aimed to investigate the effects of occupational stress on blood lipids, blood glucose and immune function of doctors.
   Methods: In 2017, 1291 doctors (565 males, 726 females) in The First Hospital Affiliated with Harbin Medical University (Harbin, China) were enrolled based on the principle of convenience of sampling and cluster sampling. Questionnaires were used to investigate demographic characteristics and occupational stress related factors. Level of glycated hemoglobin was detected by immunoturbidimetric method. Concentration of triglyceride was determined by glycerol phosphate oxidase end point method. Total cholesterol concentration in serum was determined by total cholesterol oxidase end point method. Concentration of serum immunoglobulin was detected by immunoturbidimetry.
   Results: Levels of glycated hemoglobin and triglyceride in high tension group were higher than those in the low tension group. Levels of IgG and IgM in high tension group were lower than those in low tension group. The risk of elevated glycated hemoglobinlevels in > 50-yr-old age group was higher than that of the =<35-yr-old age group. Those inthe high coping strategy group was higher in the low coping strategy group. The risk of elevated total cholesterol levels in drinkers is 1.158 times that of non-drinkers. The risk of IgG concentration reduction in smokers was 0.428 times that of non-smokers. The risk of a decrease in IgA concentration in . doctors with good sleep quality is 1.527 times that of those with poor sleep quality.
   Conclusion: Occupational stress can lead to increased blood lipids and sugar levels as well suppression of immune function in doctors.
C1 [Wang, Wenjuan] Harbin Med Univ, Dept Human Resources, Hosp 1, Harbin, Heilongjiang, Peoples R China.
   [Ren, Hui] Harbin Med Univ, Hosp 1, Dept Infect Control, Harbin, Heilongjiang, Peoples R China.
   [Tian, Qiuye] Harbin Med Univ, Hosp 1, Commiss Discipline, Harbin, Heilongjiang, Peoples R China.
   [Tang, Chunling] Harbin Med Univ, Hosp 1, Mental Hlth Ctr, Harbin, Heilongjiang, Peoples R China.
   [Meng, Wenjuan] Harbin Med Univ, Hosp 1, Dept Comprehens Archives, Harbin, Heilongjiang, Peoples R China.
C3 Harbin Medical University; Harbin Medical University; Harbin Medical
   University; Harbin Medical University; Harbin Medical University
RP Meng, WJ (corresponding author), Harbin Med Univ, Hosp 1, Dept Comprehens Archives, Harbin, Heilongjiang, Peoples R China.
EM wangwenjuan830@126.com
FU Scientific Research on Heilongjiang Health and Family Planning
   Commission [2016-012]
FX This study was supported by the Scientific Research on Heilongjiang
   Health and Family Planning Commission (2016-012).
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NR 20
TC 5
Z9 8
U1 1
U2 10
PU IRANIAN SCIENTIFIC SOCIETY MEDICAL ENTOMOLOGY
PI TEHRAN
PA SCHOOL PUBLIC HEALTH & INST HEALTH RESEARCH, TEHRAN UNIV MEDICAL
   SCIENCES, P O BOX  6446-14155, TEHRAN, 00000, IRAN
SN 2251-6085
EI 2251-6093
J9 IRAN J PUBLIC HEALTH
JI Iran J. Public Health
PD MAY
PY 2019
VL 48
IS 5
BP 825
EP 833
PG 9
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA IE9DS
UT WOS:000472675700005
PM 31523638
DA 2025-06-11
ER

PT J
AU Özkan, EA
   Khosroshahi, HE
   Kiliç, M
   Geçit, UA
   Domur, E
AF Ozkan, E. A.
   Khosroshahi, H. E.
   Kilic, M.
   Gecit, U. A.
   Domur, E.
TI Obesity-related cardiovascular behavior in children
SO EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
LA English
DT Article
DE Arterial stiffness; Children; Obesity; Ventricular stiffness
ID LEFT-VENTRICULAR GEOMETRY; END-SYSTOLIC ELASTANCE; METABOLIC SYNDROME;
   RISK-FACTORS; ADOLESCENTS; ARTERIAL; INDEX; LOAD; CONTRACTILITY;
   HYPERTENSION
AB OBJECTIVE: Obesity is a chronic metabolic disorder and may associate with cardiovascular geometrical, structural and functional changes. The aim of this study is to assess the relationship between body mass index (BMI), body surface area (BSA) and arterial-ventricular elasticity (Ea and Ees respectively) and cardiovascular coupling and myocardial wall stress and fiber stress in obese children.
   PATIENTS AND METHODS: Sixty non-obese healthy children with BMI <85th percentile aged 6-17 years and 65 age and sex-matched children with BMI of >= 95th percentile, were included in the study. Beside cardiac systolic and diastolic functions, left verntricular (LV) systolic and diastolic dimensions and volumes (LVDs, LVDd, LVVs, LVVd respectively), LV mass (LVM), LV end-systolic pressure (LVESP), meridional end-systolic wall stress (ESWm), myocardial fiber stress (MFS), Midwall Shortening Fraction (SFmid), heart rate corrected circumferential fiber shortening (VCFc), predicted mid wall fiber shortening for a measured fiber stress (mid wall VCFc), right ventricular (RV) and LV work index (RVWI, LVWI), LV relative wall thickness (LVRWT), arterial elastance (Ea), LV end-systolic elastance (Ees) and end-systolic pressure volume relationship (ESPVR) were calculated.
   RESULTS: LVDs and LVDd, LV mass (LVM), ESWSm, MFS, SF mid, Midwall VCFc and LVWI found to be significantly (p<0.001) higher, while Ea, Ees, ejection fraction (EF), fractional shortening (FS), VCFc-ESWS, RVWI, ESWSm/LVVs, LV end-systolic pressure (Pes) /LVVs and LVM/LVVd values were significantly (p<0.001) lower among obese group. By increasing age and BMI the Ea and Ees, ESWSm/LVVS and RVWI decrease; while LVDd, LVVd and stroke volume (SV) values increase. There was a reverse-relation between BMI percentiles and EF and FS.
C1 [Ozkan, E. A.; Gecit, U. A.; Domur, E.] Bozok Univ, Fac Med, Dept Pediat, Yozgat, Turkey.
   [Khosroshahi, H. E.] Bozok Univ, Fac Med, Dept Pediat Cardiol, Yozgat, Turkey.
   [Kilic, M.] Bozok Univ, Hlth Sch, Dept Publ Hlth Nursing, Yozgat, Turkey.
C3 Bozok University; Bozok University; Bozok University
RP Özkan, EA (corresponding author), Bozok Univ, Fac Med, Dept Pediat, Yozgat, Turkey.
EM uzdresra@gmail.com
RI Ozkan, Esra/KYP-1856-2024; KILIC, Mahmut/A-6694-2009
OI Domur, Esra/0000-0003-1509-548X; KILIC, Mahmut/0000-0002-8921-1597
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NR 29
TC 3
Z9 5
U1 1
U2 5
PU VERDUCI PUBLISHER
PI ROME
PA VIA GREGORIO VII, ROME, 186-00165, ITALY
SN 1128-3602
J9 EUR REV MED PHARMACO
JI Eur. Rev. Med. Pharmacol. Sci.
PD APR
PY 2016
VL 20
IS 8
BP 1559
EP 1565
PG 7
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA DS0BK
UT WOS:000380260000018
PM 27160128
DA 2025-06-11
ER

PT J
AU Li, HP
   Chen, X
   Li, MQ
AF Li, Hua-Ping
   Chen, Xuan
   Li, Ming-Qing
TI Gestational diabetes induces chronic hypoxia stress and excessive
   inflammatory response in murine placenta
SO INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY
LA English
DT Article
DE High fat diet; obesity; GDM; placenta; oxidative stress; hypoxia;
   inflammation factor
ID HIGH-FAT DIET; OXIDATIVE STRESS; METABOLIC SYNDROME; PREECLAMPSIA; MICE;
   OBESITY; ETIOLOGY; PATHWAY
AB Metabolic impairments in maternal obesity and gestational diabetes mellitus (GDM) induce an abnormal environment in peripheral blood and cause vascular structure alterations which affect the placental development and function. A GDM model was developed using C57BL/6J female mice fed with high fat food (HF) (40% energy from fat) and a control group with control food (CF) (14% energy from fat) for 14 weeks before mating and throughout the gestation period. A subset of dams was sacrificed at gestational day (GD) 18.5 to evaluate the fetal and placental development. HF-fed dams exhibited significant increase in the maternal weight gain and homeostasis model assessment for insulin resistance index (HOMA-IR), impaired insulin secretion of glucose stimulus and glucose clearance of insulin stimulus before pregnancy; in addition, they also had the increase in the fetal and placental weight. HF-fed dams at GD 18.5 showed the high level of circulating maternal inflammation factors and were associated with increased oxidative stress and hypoxia in the labyrinth, abnormal vascular development with a high level of hypoxia inducible factor-1 alpha (HIF-1 alpha) and VEGF-A expression, but without a parallel increase in CD31 level; were induced an exaggerated inflammatory response in placental vascular endothelial cell. Our findings show that GDM induces more maternal weight gain and fetus weight, with abnormal maternal circulating metabolic and inflammation factors, and forms a placental hypoxia environment and impacts the placental vascular development. Our findings indicate that gestational diabetes induce excessive chronic hypoxia stress and inflammatory response in placentas which may contribute mechanisms to the high risks of perinatal complications of obesity and GDM mothers.
C1 [Li, Hua-Ping] Shanghai Jiao Tong Univ, Peoples Hosp 6, Dept Gynecol & Obstet, Shanghai Peoples Hosp 6, Shanghai 200233, Peoples R China.
   [Chen, Xuan] Soochow Univ, Coll Med, Suzhou 215123, Peoples R China.
   [Li, Ming-Qing] Fudan Univ, Shanghai Med Coll, Hosp & Inst Obstet & Gynecol, Lab Reprod Immunol, Shanghai, Peoples R China.
C3 Shanghai Jiao Tong University; Soochow University - China; Fudan
   University
RP Li, HP (corresponding author), Shanghai Jiao Tong Univ, Peoples Hosp 6, Dept Gynecol & Obstet, Shanghai Peoples Hosp 6, 600 Yishan Rd, Shanghai 200233, Peoples R China.
EM hpli819@sohu.com
RI Li, Mingqing/AFK-9650-2022
OI Li, Ming-Qing/0000-0002-9276-0722
FU National Basic Research Program of Shanghai [12ZR1422200]
FX This study was supported by National Basic Research Program of Shanghai
   (12ZR1422200) to Hua-Ping Li.
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NR 33
TC 101
Z9 112
U1 2
U2 25
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 1936-2625
J9 INT J CLIN EXP PATHO
JI Int. J. Clin. Exp. Pathol.
PY 2013
VL 6
IS 4
BP 650
EP 659
PG 10
WC Oncology; Pathology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Pathology
GA 139HC
UT WOS:000318571700010
PM 23573311
DA 2025-06-11
ER

PT J
AU Lupachyk, S
   Watcho, P
   Hasanova, N
   Julius, U
   Obrosova, IG
AF Lupachyk, Sergey
   Watcho, Pierre
   Hasanova, Nailia
   Julius, Ulrich
   Obrosova, Irina G.
TI Triglyceride, nonesterified fatty acids, and prediabetic neuropathy:
   role for oxidative-nitrosative stress
SO FREE RADICAL BIOLOGY AND MEDICINE
LA English
DT Article
DE Acipimox; Dyslipidemia; Human Schwann cells; Insulin signaling; NAD(P)H
   oxidase; Nitrotyrosine; Oxidative-nitrosative stress; Prediabetic
   neuropathy; Superoxide; Zucker fatty (fa/fa) rat; Free radicals
ID ALPHA-LIPOIC ACID; EXPERIMENTAL DIABETIC-NEUROPATHY; IMPAIRED
   GLUCOSE-TOLERANCE; GLYCATION END-PRODUCTS; PERIPHERAL NEUROPATHY;
   INSULIN-RESISTANCE; NERVE-CONDUCTION; NITRIC-OXIDE; BLOOD-FLOW; KAPPA-B
AB Peripheral neuropathy develops in human subjects with prediabetes and metabolic syndrome before overt hyperglycemia. The contributions of impaired glucose tolerance and insulin signaling, hypertriglyceridemia and/or increased nonesterified fatty acids (NEFA), and hypercholesterolemia to this condition remain unknown. Niacin and its derivatives alleviate dyslipidemia with a minor effect on glucose homeostasis. This study evaluated the roles of impaired glucose tolerance versus dyslipidemia in prediabetic neuropathy using Zucker fatty (fa/fa) rats and the niacin derivative acipimox, as well as the interplay of hypertriglyceridemia, increased NEFA, and oxidative-nitrosative stress. Sixteen-week-old Zucker fatty rats with impaired glucose tolerance, obesity, hyperinsulinemia, hypertriglyceridemia, hypercholesterolemia, and increased NEFA displayed sensory nerve conduction velocity deficit, thermal and mechanical hypoalgesia, and tactile allodynia. Acipimox (100 mg kg(-1) day(-1), 4 weeks) reduced serum insulin, NEFA, and triglyceride concentrations without affecting glucose tolerance and hypercholesterolemia. It alleviated sensory nerve conduction velocity deficit and changes in behavioral measures of sensory function and corrected oxidative-nitrosative stress, but not impaired insulin signaling, in peripheral nerve. Elevated NEFA increased total and mitochondrial superoxide production and NAD( P)H oxidase activity in cultured human Schwann cells. In conclusion, hypertriglyceridemia and/or increased NEFA concentrations cause prediabetic neuropathy through oxidative-nitrosative stress. Lipid-lowering agents and antioxidants may find a use in the management of this condition. (C) 2012 Elsevier Inc. All rights reserved.
C1 [Lupachyk, Sergey; Watcho, Pierre; Hasanova, Nailia; Obrosova, Irina G.] Louisiana State Univ Syst, Pennington Biomed Res Ctr, Baton Rouge, LA 70808 USA.
   [Julius, Ulrich] Tech Univ Dresden, Univ Hosp, D-01062 Dresden, Germany.
C3 Louisiana State University System; Louisiana State University;
   Pennington Biomedical Research Center; Technische Universitat Dresden;
   Carl Gustav Carus University Hospital
RP Obrosova, IG (corresponding author), Louisiana State Univ Syst, Pennington Biomed Res Ctr, Baton Rouge, LA 70808 USA.
EM obrosoig@pbrc.edu
FU National Institutes of Health [RO1DK074517, RO1DK077141, RO1DK081147]
FX The study was supported in part by the National Institutes of Health
   Grants RO1DK074517, RO1DK077141, and RO1DK081147 (all to I.G.O.).
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NR 88
TC 58
Z9 65
U1 0
U2 11
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0891-5849
EI 1873-4596
J9 FREE RADICAL BIO MED
JI Free Radic. Biol. Med.
PD APR 15
PY 2012
VL 52
IS 8
BP 1255
EP 1263
DI 10.1016/j.freeradbiomed.2012.01.029
PG 9
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 920WQ
UT WOS:000302439900001
PM 22366714
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Figueiredo, ID
   Lima, TFO
   Inácio, MD
   Costa, MC
   Assis, RP
   Brunetti, IL
   Baviera, AM
AF Figueiredo, Ingrid Delbone
   Oliveira Lima, Tayra Ferreira
   Inacio, Maiara Destro
   Costa, Mariana Campos
   Assis, Renata Pires
   Brunetti, Iguatemy Lourenco
   Baviera, Amanda Martins
TI Lycopene Improves the Metformin Effects on Glycemic Control and
   Decreases Biomarkers of Glycoxidative Stress in Diabetic Rats
SO DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
LA English
DT Article
DE diabetes mellitus; combined therapy; lycopene; paraoxonase;
   glycoxidative stress
ID GLUCOSE-TOLERANCE; POSTPRANDIAL HYPERGLYCEMIA; COMBINATION THERAPY;
   INSULIN SENSITIVITY; METABOLIC SYNDROME; OXIDATIVE STRESS; NEPHROPATHY;
   MELLITUS; DYSLIPIDEMIA; INFLAMMATION
AB Introduction: Oxidative stress and exacerbated generation of advanced glycation end products (AGEs) participate in the onset of diabetic complications. Lycopene is a potent antioxidant; evidence accounts for its ability to mitigate diabetic disturbances, including the deleterious events of advanced glycation. Therefore, this carotenoid has emerged as a candidate to be used in combination with antidiabetic drugs, such as metformin, attempting to counteract the glycoxidative stress. This study investigated the effects of the treatments with lycopene or metformin, alone or in combination, on glycoxidative stress biomarkers and antioxidant defenses in diabetic rats.
   Methods: Streptozotocin-induced diabetic rats were treated for 35 days with lycopene (45 mg/kg) or metformin (250 mg/kg), alone or as mixtures in yoghurt. Plasma levels of glucose, triglycerides, cholesterol, thiobarbituric acid reactive substances and protein carbonyl groups (biomarkers of oxidative damage), fluorescent AGEs (biomarkers of advanced glycation), and paraoxonase 1 activity (antioxidant enzyme) were assessed. Changes in the hepatic and renal levels of glycoxidative damage biomarkers and the activities of antioxidant enzymes were investigated.
   Results: The combination of lycopene with metformin maintained the beneficial effects of the isolated treatments, improving the glucose tolerance and lipid profile, lessening biomarkers of oxidative damage, and increasing the paraoxonase 1 activity. Besides, the combined therapy caused further decreases in postprandial glycemia, plasma levels of cholesterol and AGEs, avoided lipid peroxidation (plasma, kidney), and increased antioxidant defenses, mainly the activity of superoxide dismutase (liver, kidney), indicating the maintenance of the lycopene effects.
   Conclusion: Lycopene combined with metformin may act synergistically in the control of postprandial glycemia, dyslipidemia and glycoxidative stress, as well as increased antioxidant defenses, arising as a promising therapeutic strategy to mitigate diabetic complications.
C1 [Figueiredo, Ingrid Delbone; Oliveira Lima, Tayra Ferreira; Inacio, Maiara Destro; Costa, Mariana Campos; Assis, Renata Pires; Brunetti, Iguatemy Lourenco; Baviera, Amanda Martins] Sao Paulo State Univ Unesp, Sch Pharmaceut Sci, Dept Clin Anal, Araraquara, SP, Brazil.
C3 Universidade Estadual Paulista
RP Baviera, AM (corresponding author), Sao Paulo State Univ, Sch Pharmaceut Sci, Dept Clin Anal, Rodovia Araraquara Jau,Km 01 S-N, BR-14800903 Araraquara, SP, Brazil.
EM amanda.baviera@unesp.br
RI Assis, Renata/HGD-9366-2022; Brunetti, Iguatemy/AAS-8362-2021; Baviera,
   Amanda/O-2028-2019
OI Brunetti, Iguatemy Lourenco/0000-0003-4927-7599; Delbone Figueiredo,
   Ingrid/0000-0003-1558-2894; Baviera, Amanda Martins/0000-0003-0987-5295
FU Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES),
   Brazil [001]
FX During this study I. D. Figueiredo received scholarship from the
   Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES),
   Brazil - Finance Code 001. Data presented in this study were from the
   MSc thesis of I. D. Figueiredo.
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NR 59
TC 22
Z9 24
U1 0
U2 4
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-7007
J9 DIABET METAB SYND OB
JI Diabetes Metab. Syndr. Obes.
PY 2020
VL 13
BP 3117
EP 3135
DI 10.2147/DMSO.S265944
PG 19
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA NR3YH
UT WOS:000571498700001
PM 32982345
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Tarry-Adkins, JL
   Chen, JH
   Jones, RH
   Smith, NH
   Ozanne, SE
AF Tarry-Adkins, Jane L.
   Chen, Jian-Hua
   Jones, Richard H.
   Smith, Noel H.
   Ozanne, Susan E.
TI Poor maternal nutrition leads to alterations in oxidative stress,
   antioxidant defense capacity, and markers of fibrosis in rat islets:
   potential underlying mechanisms for development of the diabetic
   phenotype in later life
SO FASEB JOURNAL
LA English
DT Article
DE hyperglycemia; fibrosis; type 2 diabetes
ID LOW-PROTEIN-DIET; LOW-BIRTH-WEIGHT; PANCREATIC-ISLETS;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; GLUCOSE-TOLERANCE; HEME
   OXYGENASE-1; PROTECTIVE ROLE; NADPH OXIDASES; FREE-RADICALS
AB Low birth weight is associated with glucose intolerance, insulin resistance, and type 2 diabetes (T2D) in later life. Good evidence indicates that the environment plays an important role in this relationship. However, the mechanisms underlying these relationships are defined poorly. Islets are particularly susceptible to oxidative stress, and this condition combined with fibrosis is thought to be instrumental in T2D pathogenesis. Here we use our maternal low-protein (LP) rat model to determine the effect of early diet on oxidative stress and fibrosis in pancreatic islets of male offspring at 3 and 15 mo of age. Islet xanthine oxidase (XO) expression was increased in 15-mo LP offspring, which suggests increased oxidative-stress. Manganese superoxide-dismutase (MnSOD), copper-zinc superoxide dismutase (CuZnSOD), and heme oxygenase-1 (HO-1) (antioxidant enzymes) were reduced significantly in LP offspring, which indicated impairment of oxidative defense. Expression of fibrosis markers collagen I and collagen III also increased in 15-mo LP offspring. Angiotensin II receptor type I (AT(II)R(I)), induced by hyperglycemia and oxidative-stress, was significantly up-regulated in 15-mo LP offspring. Lipid peroxidation was also increased in 15-mo LP animals. We conclude that maternal protein restriction causes age-associated increased oxidative stress, impairment of oxidative defense, and fibrosis. These findings provide mechanisms by which suboptimal early nutrition can lead to T2D development later in life.-TarryAdkins, J. L., Chen, J.-H., Jones, R. H., Smith, N. H., Ozanne, S. E. Poor maternal nutrition leads to alterations in oxidative stress, antioxidant defense capacity, and markers of fibrosis in rat islets: potential underlying mechanisms for development of the diabetic phenotype in later life. FASEB J. 24, 2762-2771 (2010). www.fasebj.org
C1 [Tarry-Adkins, Jane L.; Chen, Jian-Hua; Jones, Richard H.; Smith, Noel H.; Ozanne, Susan E.] Univ Cambridge, Metab Res Labs, Inst Metab Sci, Addenbrookes Treatment Ctr,Addenbrookes Hosp, Cambridge CB2 0QQ, England.
C3 University of Cambridge; Cambridge University Hospitals NHS Foundation
   Trust; Addenbrooke's Hospital
RP Tarry-Adkins, JL (corresponding author), Univ Cambridge, Metab Res Labs, Inst Metab Sci, Addenbrookes Treatment Ctr,Addenbrookes Hosp, Level 4,Box 289,Hills Rd, Cambridge CB2 0QQ, England.
EM janeadkins@googlemail.com
RI Chen, Jianhua/G-1351-2019
OI Tarry-Adkins, Jane/0000-0001-9569-6132; Ozanne,
   Susan/0000-0001-8753-5144
FU British Heart Foundation; Biotechnology and Biological Sciences Research
   Council; Medical Research Council Centre for Obesity and Related
   Metabolic Diseases; Parthenon Trust; BBSRC [BB/E002161/1, BB/E00797X/1,
   BB/F015364/1, BB/D007909/1] Funding Source: UKRI
FX The authors thank A. Wayman and D. Hawkes for their technical expertise.
   This work was supported by the British Heart Foundation, the
   Biotechnology and Biological Sciences Research Council, the Medical
   Research Council Centre for Obesity and Related Metabolic Diseases, and
   the Parthenon Trust.
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NR 55
TC 71
Z9 78
U1 0
U2 5
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
EI 1530-6860
J9 FASEB J
JI Faseb J.
PD AUG
PY 2010
VL 24
IS 8
BP 2762
EP 2771
DI 10.1096/fj.10-156075
PG 10
WC Biochemistry & Molecular Biology; Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 690LD
UT WOS:000285005400017
PM 20388698
DA 2025-06-11
ER

PT J
AU Lee, VV
   Han, YY
   Toh, DF
   Bryant, JA
   Boubertakh, R
   Le, TT
   Chin, CWL
AF Lee, Vivian
   Han, Yiying
   Toh, Desiree-Faye
   Bryant, Jennifer A.
   Boubertakh, Redha
   Le, Thu-Thao
   Chin, Calvin W. L.
TI Differential association of abdominal, liver, and epicardial adiposity
   with anthropometry, diabetes, and cardiac remodeling in Asians
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Article
DE cardiometabolic disease; fat distribution; visceral adiposity; diabetes;
   anthropometric indices; epicardial fat; cardiac remodeling; magnetic
   resonance imaging
ID LARGE-VOLUME LIPOSUCTION; METABOLIC RISK-FACTORS; VISCERAL FAT;
   INSULIN-RESISTANCE; HEART-FAILURE; TISSUE; DISEASE; OBESITY; PROFILE;
   AREA
AB Background: Heterogenous deposition and homeostasis roles of physiologic and ectopic adipose tissues underscore the impact of fat compartmentalization on cardiometabolic risk. We aimed to characterize the distribution of abdominal visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), epicardial adipose tissue (EAT), and liver fat on magnetic resonance imaging (MRI), and evaluate their associations with anthropometric indices and adverse cardiac remodeling. Methods: In this cross-sectional observational study, 149 Asian adults (57.0 +/- 12.8 years; 65% males) with at least one cardiometabolic risk factor underwent multiparametric fat and cardiovascular MRI. Anthropometric indices included body mass index (BMI), waist circumference (WC), waist-hip ratio (WHR), and bioimpedance body fat mass (BFM). Associations between fat depots and anthropometric measures as well as cardiac remodeling features were examined as a single cohort and stratified by type 2 diabetes mellitus (T2DM) status. Results: VAT and SAT had opposing associations with liver fat and EAT. Therefore the VAT/SAT ratio was explored as an integrated marker of visceral adiposity. VAT/SAT was positively associated with EAT (beta=0.35, P<0.001) and liver fat (beta=0.32, P=0.003) independent of confounders. Of the anthropometric measurements assessed, only WHR was independently associated with VAT/SAT (beta=0.17, P=0.021). Individuals with T2DM had higher VAT and lower SAT compared to those without T2DM, translating to a significantly higher VAT/SAT ratio. EAT volume was independently associated with adverse features of cardiac remodeling: increased left ventricular (LV) mass (beta=0.24, P=0.005), larger myocyte volume (beta=0.26, P=0.001), increased myocardial fibrosis (beta=0.19, P=0.023), higher concentricity (beta=0.18, P=0.035), and elevated wall stress (beta=-0.18, P=0.023). Conclusion: Multiparametric MRI revealed abdominal VAT and SAT have differential associations with anthropometric indices and ectopic fats in a single cohort of Asians at risk of cardiometabolic disease. People with T2DM have expanded VAT and diminished SAT, endorsing the VAT/SAT ratio beyond usual anthropometric measurements as a marker for multiorgan visceral fat composition. Among the fat depots examined, EAT is uniquely associated with adverse cardiac remodeling, suggesting its distinctive cardiometabolic properties and implications.
C1 [Lee, Vivian; Toh, Desiree-Faye; Boubertakh, Redha; Le, Thu-Thao; Chin, Calvin W. L.] Natl Heart Ctr Singapore, Natl Heart Res Inst Singapore NHRIS, Singapore, Singapore.
   [Han, Yiying; Bryant, Jennifer A.; Chin, Calvin W. L.] Natl Heart Ctr Singapore, Dept Cardiol, Singapore, Singapore.
   [Boubertakh, Redha; Le, Thu-Thao; Chin, Calvin W. L.] Duke Natl Univ Singapore Duke NUS Med Sch, Cardiovasc Acad Clin Program ACP, Singapore, Singapore.
C3 National Heart Centre Singapore; National Heart Centre Singapore
RP Chin, CWL (corresponding author), Natl Heart Ctr Singapore, Natl Heart Res Inst Singapore NHRIS, Singapore, Singapore.; Chin, CWL (corresponding author), Natl Heart Ctr Singapore, Dept Cardiol, Singapore, Singapore.; Chin, CWL (corresponding author), Duke Natl Univ Singapore Duke NUS Med Sch, Cardiovasc Acad Clin Program ACP, Singapore, Singapore.
EM cchin03m@gmail.com
RI Toh, Desiree-Faye/GPX-5818-2022
FU National Medical Research Council10.13039/501100001349
FX The authors thank the study participants, radiographers, and the Biobank
   at the National Heart Centre of Singapore for their assistance in the
   study.
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NR 61
TC 1
Z9 1
U1 2
U2 5
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD AUG 23
PY 2024
VL 15
AR 1439691
DI 10.3389/fendo.2024.1439691
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA F4J7G
UT WOS:001309503100001
PM 39257902
OA gold
DA 2025-06-11
ER

PT J
AU Blackmore, K
   Houchen, CJ
   Simonyan, H
   Arestakesyan, H
   Stark, AK
   Dow, SA
   Kim, HR
   Jeong, JK
   Popratiloff, A
   Young, CN
AF Blackmore, Katherine
   Houchen, Claire J.
   Simonyan, Hayk
   Arestakesyan, Hovhannes
   Stark, Alyssa K.
   Dow, Samantha A.
   Kim, Han Rae
   Jeong, Jin Kwon
   Popratiloff, Anastas
   Young, Colin N.
TI A forebrain-hypothalamic ER stress driven circuit mediates hepatic
   steatosis during obesity
SO MOLECULAR METABOLISM
LA English
DT Article
DE Non-alcoholic fatty liver disease; Subfornical organ; Paraventricular
   nucleus of the hypothalamus; Endoplasmic reticulum; Unfolded protein
   response; Sympathetic nervous system
ID FATTY LIVER-DISEASE; SUBFORNICAL ORGAN; METABOLIC SYNDROME;
   INFLAMMATION; CONNECTIONS; EXPRESSION; NEURONS; ROLES; DEATH
AB Objective: Non-alcoholic fatty liver disease (NAFLD) affects 1 in 3 adults and contributes to advanced liver injury and cardiometabolic disease. While recent evidence points to involvement of the brain in NAFLD, the downstream neural circuits and neuronal molecular mechanisms involved in this response, remain unclear. Here, we investigated the role of a unique forebrain-hypothalamic circuit in NAFLD. Methods: Chemogenetic activation and inhibition of circumventricular subfornical organ (SFO) neurons that project to the paraventricular nucleus of the hypothalamus (PVN; SFO -> PVN) in mice were used to study the role of SFO -> PVN signaling in NAFLD. Novel scanning electron microscopy techniques, histological approaches, molecular biology techniques, and viral methodologies were further used to delineate the role of endoplasmic reticulum (ER) stress within this circuit in driving NAFLD. Results: In lean animals, acute chemogenetic activation of SFO -> PVN neurons was sufficient to cause hepatic steatosis in a liver sympathetic nerve dependent manner. Conversely, inhibition of this forebrain-hypothalamic circuit rescued obesity-associated NAFLD. Furthermore, dietary NAFLD is associated with marked ER ultrastructural alterations and ER stress in the PVN, which was blunted following reductions in excitatory signaling from the SFO. Finally, selective inhibition of PVN ER stress reduced hepatic steatosis during obesity. Conclusions: Collectively, these findings characterize a previously unrecognized forebrain-hypothalamic-ER stress circuit that is involved in hepatic steatosis, which may point to future therapeutic strategies for NAFLD. (c) 2023 The Author(s). Published by Elsevier GmbH. This is an open access article under the CC BY -NC -ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
C1 [Blackmore, Katherine; Houchen, Claire J.; Simonyan, Hayk; Arestakesyan, Hovhannes; Stark, Alyssa K.; Dow, Samantha A.; Kim, Han Rae; Jeong, Jin Kwon; Young, Colin N.] George Washington Univ, Sch Med & Hlth Sci, Dept Pharmacol & Physiol, Washington, DC 20037 USA.
   [Popratiloff, Anastas] George Washington Univ, Nanofabricat & Imaging Ctr, Washington, DC 20037 USA.
   [Young, Colin N.] George Washington Univ, Sch Med & Hlth Sci, Dept Pharmacol & Physiol, 2300 1Street NW,650 Ross Hall, Washington, DC 20037 USA.
C3 George Washington University; George Washington University; George
   Washington University
RP Young, CN (corresponding author), George Washington Univ, Sch Med & Hlth Sci, Dept Pharmacol & Physiol, 2300 1Street NW,650 Ross Hall, Washington, DC 20037 USA.
EM colinyoung@gwu.edu
RI Jeong, Jin/AAU-2951-2020
OI Stark, Alyssa/0009-0009-1222-6692; Kim, Han Rae/0000-0002-9108-2421;
   Arestakesyan, Hovhannes/0000-0002-6228-0998; Popratiloff,
   Anastas/0000-0002-8329-3907; Dow, Samantha/0000-0003-2146-0877
FU National Institutes of Health [F31DK122747, R01HL141393, R01DK117007]
FX <BOLD>Acknowledgments</BOLD> This research was funded by National
   Institutes of Health grants F31DK122747, R01HL141393, and R01DK117007.
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NR 55
TC 2
Z9 2
U1 3
U2 24
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2212-8778
J9 MOL METAB
JI Mol. Metab.
PD JAN
PY 2024
VL 79
AR 101858
DI 10.1016/j.molmet.2023.101858
EA JAN 2024
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA GT9E8
UT WOS:001155033600001
PM 38141847
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Kurihara, Y
   Walenna, NF
   Ishii, K
   Soejima, T
   Chou, B
   Yoshimura, M
   Ozuru, R
   Shimizu, A
   Itoh, R
   Furuhashi, M
   Hotamisligil, GS
   Hiromatsu, K
AF Kurihara, Yusuke
   Walenna, Nirwana Fitriani
   Ishii, Kazunari
   Soejima, Toshinori
   Chou, Bin
   Yoshimura, Michinobu
   Ozuru, Ryo
   Shimizu, Akinori
   Itoh, Ryota
   Furuhashi, Masato
   Hotamisligil, Gokhan S.
   Hiromatsu, Kenji
TI Chlamydia pneumoniae Lung Infection in Mice Induces Fatty
   Acid-Binding Protein 4-Dependent White Adipose Tissue Pathology
SO JOURNAL OF IMMUNOLOGY
LA English
DT Article
ID ENDOPLASMIC-RETICULUM STRESS; INSULIN-RESISTANCE; INTRACELLULAR GROWTH;
   RISK-FACTOR; ER STRESS; MACROPHAGES; FABP4; SUSCEPTIBILITY;
   INFLAMMATION; OBESITY
AB Fatty acid -binding protein 4 (FABP4) is a critical immune-metabolic modulator, mainly expressed in adipocytes and macrophages, secreted from adipocytes in association with lipolysis, and plays essential pathogenic roles in cardiovascular and metabolic diseases. We previously reported Chlamydia pneumoniae infecting murine 3T3-L1 adipocytes and causing lipolysis and FABP4 secretion in vitro. However, it is still unknown whether C. pneumoniae intranasal lung infection targets white adipose tissues (WATs), induces lipolysis, and causes FABP4 secretion in vivo. In this study, we demonstrate that C. pneumoniae lung infection causes robust lipolysis in WAT. Infection-induced WAT lipolysis was diminished in FABP4-/- mice or FABP4 inhibitor -pretreated wild-type mice. Infection by C. pneumoniae in wild-type but not FABP4-/- mice induces the accumulation of TNF-a- and IL-6 -producing M1-like adipose tissue macrophages in WAT. Infection-induced WAT pathology is augmented by endoplasmic reticulum (ER) stress/the unfolded protein response (UPR), which is abrogated by treatment with azoramide, a modulator of the UPR. C. pneumoniae lung infection is suggested to target WAT and induce lipolysis and FABP4 secretion in vivo via ER stress/UPR. FABP4 released from infected adipocytes may be taken up by other neighboring intact adipocytes or adipose tissue macrophages. This process can further induce ER stress activation and trigger lipolysis and inflammation, followed by FABP4 secretion, leading to WAT pathology. A better understanding of the role of FABP4 in C. pneumoniae infection -induced WAT pathology will provide the basis for rational intervention measures directed at C. pneumoniae infection and metabolic syndrome, such as atherosclerosis, for which robust epidemiologic evidence exists. The Journal of Immunology, 2023, 210: 1086-1097.
C1 [Kurihara, Yusuke; Walenna, Nirwana Fitriani; Ishii, Kazunari; Soejima, Toshinori; Chou, Bin; Yoshimura, Michinobu; Ozuru, Ryo; Shimizu, Akinori; Itoh, Ryota; Hiromatsu, Kenji] Fukuoka Univ, Fac Med, Dept Microbiol & Immunol, 7-45-1Nanakuma, Fukuoka 8140180, Japan.
   [Walenna, Nirwana Fitriani] Kyushu Univ, Grad Sch Med Sci, Dept Bacteriol, Fukuoka, Japan.
   [Furuhashi, Masato] Sapporo Med Univ, Sch Med, Dept Cardiovasc Renal & Metab Med, Sapporo, Japan.
   [Hotamisligil, Gokhan S.] Harvard TH Chan Sch Publ Hlth, Sabri Ulker Ctr Metab Res, Boston, MA USA.
   [Hotamisligil, Gokhan S.] Harvard TH Chan Sch Publ Hlth, Dept Mol Metab, Boston, MA USA.
   [Hotamisligil, Gokhan S.] Broad Inst MIT & Harvard, Cambridge, MA USA.
   [Walenna, Nirwana Fitriani] Hasanuddin Univ, Fac Med, Makassar, South Sulawesi, Indonesia.
C3 Fukuoka University; Kyushu University; Sapporo Medical University;
   Harvard University; Harvard T.H. Chan School of Public Health; Harvard
   University; Harvard T.H. Chan School of Public Health; Harvard
   University; Massachusetts Institute of Technology (MIT); Broad
   Institute; Universitas Hasanuddin
RP Hiromatsu, K (corresponding author), Fukuoka Univ, Fac Med, Dept Microbiol & Immunol, 7-45-1Nanakuma, Fukuoka 8140180, Japan.
EM khiromatsu@fukuoka-u.ac.jp
RI Hotamisligil, Gokhan/ABL-2919-2022; Walenna, Nirwana
   Fitriani/AAC-7560-2020; Furuhashi, Masato/AAT-5518-2021
OI Shimizu, Akinori/0000-0003-2691-2297; Ishii,
   Kazunari/0000-0001-8696-4959; Walenna, Nirwana
   Fitriani/0000-0002-3992-5604
FU Japan Society for the Promotion of Science [19K16659, 22K08614,
   21K16329]; Grants-in-Aid for Scientific Research [21K16329, 22K08614,
   23K07993, 20K08913] Funding Source: KAKEN
FX This work was supported in part by an Indonesia Endowment Fund for
   Education scholarship from the Ministry of Finance of the Republic of
   Indonesia (to N.F.W.) andr by Japan Society for the Promotion of Science
   Grants-in-Aid for Scientific Research 19K16659 (to Y.K.) , 22K08614 (to
   K.I.) , and 21K16329 (to M.Y.) .
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NR 41
TC 3
Z9 4
U1 0
U2 1
PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-1767
EI 1550-6606
J9 J IMMUNOL
JI J. Immunol.
PD APR 15
PY 2023
VL 210
IS 8
BP 1086
EP 1097
DI 10.4049/jimmunol.2200601
PG 12
WC Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology
GA W6LS9
UT WOS:001092728200004
PM 36883861
OA Bronze
DA 2025-06-11
ER

PT J
AU Yokota, SI
   Ando, M
   Aoyama, S
   Nakamura, K
   Shibata, S
AF Yokota, Shin-Ichi
   Ando, Midori
   Aoyama, Shinya
   Nakamura, Kawai
   Shibata, Shigenobu
TI Leucine restores murine hepatic triglyceride accumulation induced by a
   low-protein diet by suppressing autophagy and excessive endoplasmic
   reticulum stress
SO AMINO ACIDS
LA English
DT Article
DE Fatty liver; Metabolic syndrome; Autophagy; ER stress; Unfolded protein
   response
ID CHAIN AMINO-ACIDS; FATTY LIVER; LIPID-METABOLISM; INDUCED OBESITY;
   MESSENGER-RNA; ER STRESS; RAT-LIVER; MICE; ACTIVATION; STEATOSIS
AB Although it is known that a low-protein diet induces hepatic triglyceride (TG) accumulation in both rodents and humans, little is known about the underlying mechanism. In the present study, we modeled hepatic TG accumulation by inducing dietary protein deficiency in mice and aimed to determine whether certain amino acids could prevent low-protein diet-induced TG accumulation in the mouse liver. Mice fed a diet consisting of 3 % casein (3C diet) for 7 days showed hepatic TG accumulation with up-regulation of TG synthesis for the Acc gene and down-regulation of TG-rich lipoprotein secretion from hepatocytes for Mttp genes. Supplementing the 3 % casein diet with essential amino acids, branched-chain amino acids, or the single amino acid leucine rescued hepatic TG accumulation. In the livers of mice fed the 3 % casein diet, we observed a decrease in the levels of the autophagy substrate p62, an increase in the expression levels of the autophagy marker LC3-II, and an increase in the splicing of the endoplasmic reticulum (ER) stress-dependent Xbp1 gene. Leucine supplementation to the 3 % casein diet did not affect genes related to lipid metabolism, but inhibited the decrease in p62, the increase in LC3-II, and the increase in Xbp1 splicing levels in the liver. Our results suggest that ER stress responses and activated autophagy play critical roles in low-protein diet-induced hepatic TG accumulation in mice, and that leucine suppresses these two major protein degradation systems. This study contributes to understanding the mechanisms of hepatic disorders of lipid metabolism.
C1 [Yokota, Shin-Ichi; Ando, Midori; Aoyama, Shinya; Nakamura, Kawai; Shibata, Shigenobu] Waseda Univ, Sch Adv Sci & Engn, Lab Physiol & Pharmacol, Tokyo 1628480, Japan.
   [Yokota, Shin-Ichi] Waseda Univ, Consolidated Res Inst Adv Sci & Med Care, Tokyo 1628480, Japan.
C3 Waseda University; Waseda University
RP Shibata, S (corresponding author), Waseda Univ, Sch Adv Sci & Engn, Lab Physiol & Pharmacol, Tokyo 1628480, Japan.
EM shibatas@waseda.jp
OI Aoyama, Shinya/0000-0001-7589-676X
FU Council for Science, Technology and Innovation, SIP, "Technologies for
   creating next-generation agriculture, forestry and fisheries" (funding
   agency: Bio-oriented Technology Research Advancement Institution, NARO);
   Ministry of Education, Culture, Sports, Science, and Technology of Japan
   [26220201]; Japan Society for the Promotion of Science [15K07740];
   Grants-in-Aid for Scientific Research [15K07740] Funding Source: KAKEN
FX This work was partially supported by the Council for Science, Technology
   and Innovation, SIP, "Technologies for creating next-generation
   agriculture, forestry and fisheries" (funding agency: Bio-oriented
   Technology Research Advancement Institution, NARO) (S. S.); by a
   Grant-in-Aid for Scientific Research (S) (26220201) from the Ministry of
   Education, Culture, Sports, Science, and Technology of Japan (S. S.);
   and by a Grant-in-Aid for Scientific Research (C) (15K07740) from the
   Japan Society for the Promotion of Science (S. Y.). No additional
   external funding was received for this study.
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NR 43
TC 26
Z9 37
U1 1
U2 31
PU SPRINGER WIEN
PI WIEN
PA SACHSENPLATZ 4-6, PO BOX 89, A-1201 WIEN, AUSTRIA
SN 0939-4451
EI 1438-2199
J9 AMINO ACIDS
JI Amino Acids
PD APR
PY 2016
VL 48
IS 4
BP 1013
EP 1021
DI 10.1007/s00726-015-2149-0
PG 9
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA DH1NH
UT WOS:000372551100011
PM 26707165
DA 2025-06-11
ER

PT J
AU Dreger, H
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   Stangl, K
   Meiners, S
AF Dreger, Henryk
   Westphal, Kera
   Wilck, Nicola
   Baumann, Gert
   Stangl, Verena
   Stangl, Karl
   Meiners, Silke
TI Protection of vascular cells from oxidative stress by proteasome
   inhibition depends on Nrf2
SO CARDIOVASCULAR RESEARCH
LA English
DT Article
DE Oxidative stress; Endothelial cells; Vascular smooth muscle cells;
   Proteasome inhibitor; Nrf2; Antioxidant response element;
   Preconditioning
ID ANTIOXIDANT RESPONSE ELEMENT; TRANSCRIPTION FACTOR NRF2;
   CORONARY-ARTERY-DISEASE; ENDOTHELIAL-CELLS; GENE-EXPRESSION;
   METABOLIC-SYNDROME; ASCORBIC-ACID; UP-REGULATION; KAPPA-B; PATHWAY
AB Increased levels of reactive oxygen species cause oxidative stress and severely damage lipids, proteins, and DNA. We have previously shown that partial proteasome inhibition induces an antioxidative gene pattern in endothelial cells. Here, we elucidate the mechanisms of proteasome inhibitor-mediated upregulation of antioxidative enzymes and cytoprotection.
   Non-toxic proteasome inhibition upregulated mRNA and protein expression of superoxide dismutase 1 (SOD1) and haem oxygenase 1 (HO1) in several human endothelial and vascular smooth muscle cell types. Transcriptional activation of these enzymes was shown by inhibition of RNA polymerase II and nuclear run-on assays. Transfection of endothelial cells with luciferase reporter constructs revealed that upregulation can be largely confined to an antioxidant response element (ARE), which proved to be sufficient for transcriptional activation of SOD1 and HO1. Co-transfection studies and bandshift analyses confirmed binding of the antioxidative transcription factor NF-E2-related factor 2 (Nrf2)-which was stabilized by proteasome inhibition as shown by immunoblots-to the ARE site of HO1. Experiments with aortic endothelial and smooth muscle cells from Nrf2 wild-type and knockout mice revealed an essential role of Nrf2: in wild-type cells, proteasome inhibitor-mediated induction of SOD1 and HO1 was accompanied by protection of vascular cells against oxidative stress as determined by lactate dehydrogenase release assays. In contrast, proteasome inhibitor-mediated induction of antioxidative enzymes and cytoprotection were completely lost in cells from Nrf2 knockout mice.
   Nrf2-dependent transcriptional activation of antioxidative enzymes is crucial for proteasome inhibitor-mediated protection of vascular cells against oxidative stress.
C1 [Dreger, Henryk; Westphal, Kera; Wilck, Nicola; Baumann, Gert; Stangl, Verena; Stangl, Karl; Meiners, Silke] Charite, Med Klin Kardiol & Angiol, D-10117 Berlin, Germany.
C3 Berlin Institute of Health; Free University of Berlin; Humboldt
   University of Berlin; Charite Universitatsmedizin Berlin
RP Stangl, K (corresponding author), Charite, Med Klin Kardiol & Angiol, Charitepl 1, D-10117 Berlin, Germany.
EM karl.stangl@charite.de
RI Dreger, Henryk/A-9733-2009; Meiners, Silke/M-9822-2014
OI Wilck, Nicola/0000-0003-3189-5364; Dreger, Henryk/0000-0003-1909-4329;
   Meiners, Silke/0000-0003-3678-7995
FU Deutsche Forschungsgemeinschaft (DFG) [DFG Nrf2/STA567/4-1, 865]
FX Part of this work was supported by a grant from the Deutsche
   Forschungsgemeinschaft (DFG) to K. S. and S. M. [DFG Nrf2/STA567/4-1].
   S. M. was a research fellow of the Charite-Universitatsmedizin Berlin.
   K. W. has been supported by the DFG Graduiertenkolleg 865.
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NR 59
TC 79
Z9 90
U1 2
U2 18
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0008-6363
EI 1755-3245
J9 CARDIOVASC RES
JI Cardiovasc. Res.
PD JAN 15
PY 2010
VL 85
IS 2
BP 395
EP 403
DI 10.1093/cvr/cvp279
PG 9
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 537NE
UT WOS:000273118900017
PM 19679681
OA Bronze
DA 2025-06-11
ER

PT J
AU An, YC
   Zhao, HB
   He, CH
   Shi, L
   Su, XH
   Zhang, HL
   Huang, Y
   Shan, ZY
   Wang, ML
   Du, YH
   Xie, JM
   Zhao, YG
   Yang, Y
   Huang, ZY
   Wan, AF
   Zhao, Y
   Zhao, BS
AF An, Yongcheng
   Zhao, Hongbin
   He, Changhao
   Shi, Lu
   Su, Xiaohua
   Zhang, Huilin
   Huang, Yan
   Shan, Ziyi
   Wang, Menglu
   Du, Yuhang
   Xie, Jiamei
   Zhao, Yige
   Yang, Yang
   Huang, Zhiyun
   Wan, Anfeng
   Zhao, Ying
   Zhao, Baosheng
TI Xiasangju alleviates hepatic insulin resistance in db/db mice via
   AMPK pathway: Mechanisms and active components study
SO INTERNATIONAL IMMUNOPHARMACOLOGY
LA English
DT Article
DE Xiasangju; Type 2 diabetes mellitus; Insulin resistance; AMPK; Oxidative
   stress; 4-Methylesculetin
ID OXIDATIVE STRESS; NADPH OXIDASE; GLYCOGEN-SYNTHESIS; DIABETES-MELLITUS;
   SIGNALING PATHWAY; ACTIVATION; GLUCONEOGENESIS; HEPATOCYTES; METABOLISM;
   EXPRESSION
AB Type 2 diabetes mellitus (T2DM), one of the prevalent chronic diseases, significantly impacts individuals and society. Xiasangju (XSJ), a herbal tea formulation, has been commonly used in traditional Chinese medicine. Accumulating evidence suggests that XSJ can alleviate metabolic syndrome by regulating glucose and lipid metabolism, lowering liver index and improving glucose tolerance. In the present study, db/db mice were used to examine the effect of XSJ on treating T2DM, and Western blotting was performed to explore the underlying antiT2DM pharmacological mechanisms. With AMP-activated protein kinase (AMPK) chosen as the target protein, surface plasmon resonance (SPR)-LC-MS technology was used to identify potential active ingredients of XSJ. To further explore the role of potential active ingredients of XSJ, their effects were investigated in insulin resistance (IR)-HepG2 cells. Our results demonstrate that in diabetic db/db mice, XSJ activated the AMPK pathway, which regulated hepatic glucose metabolism and inhibited oxidative stress caused by hepatic NADPH oxidase 4 (NOX4), thereby ameliorating hepatic IR. By means of SPR-LC-MS experiments, 4-Methylesculetin was identified as an important active ingredient in XSJ. Subsequently, to further elucidate the effects of this ingredient, in IR-HepG2 cells, 4-Methylesculetin was found to mitigate oxidative stress, enhance glucose consumption, and promote glycogen synthesis. This study demonstrated that XSJ improved T2DM and mitigated oxidative stress by activating the AMPK pathway. Specifically, 4-Methylesculetin emerged as a promising therapeutic agent for T2DM.
C1 [An, Yongcheng; Zhang, Huilin; Wang, Menglu; Du, Yuhang; Xie, Jiamei; Zhao, Yige; Yang, Yang] Beijing Univ Chinese Med, Sch Chinese Mat Med, Dept Pharmacol, Beijing 102488, Peoples R China.
   [Zhao, Hongbin] Beijing Univ Chinese Med, Dongzhimen Hosp, Dept Oncol & Hematol, Beijing 100700, Peoples R China.
   [He, Changhao] Zhejiang Chinese Med Univ, Sch Pharm, Hangzhou 310053, Zhejiang, Peoples R China.
   [Shi, Lu] Univ Hlth & Rehabil Sci, Qingdao Municipal Hosp, Cent Labs, Qingdao 266001, Peoples R China.
   [Su, Xiaohua; Huang, Zhiyun; Wan, Anfeng] Guangzhou Baiyunshan Xingqun Pharmaceut Co Ltd, Guangzhou 510288, Peoples R China.
   [Huang, Yan; Shan, Ziyi] Beijing Univ Chinese Med, Sch Life Sci, Beijing 102488, Peoples R China.
   [Zhao, Ying] Beijing Univ Chinese Med, Affiliated Hosp 3, Beijing 100029, Peoples R China.
   [Zhao, Baosheng] Beijing Univ Chinese Med, Beijing Res Inst Chinese Med, Beijing 100029, Peoples R China.
C3 Beijing University of Chinese Medicine; Beijing University of Chinese
   Medicine; Zhejiang Chinese Medical University; Qingdao Municipal
   Hospital; University of Health & Rehabilitation Sciences; Beijing
   University of Chinese Medicine; Beijing University of Chinese Medicine;
   Beijing University of Chinese Medicine
RP Zhao, Y; Zhao, BS (corresponding author), Bei San Huan East Rd, Beijing 100029, Peoples R China.
EM yiingzhaozhao@163.com; zhaobs1973@163.com
RI DU, YUHANG/AAJ-7745-2021; An, yongchen/JDX-0597-2023
FU National Natural Science Foundation of China [82274166]
FX <BOLD>Funding</BOLD> This work was supported by the National Natural
   Science Foundation of China (No. 82274166) .
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NR 62
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1567-5769
EI 1878-1705
J9 INT IMMUNOPHARMACOL
JI Int. Immunopharmacol.
PD MAY 27
PY 2025
VL 156
AR 114675
DI 10.1016/j.intimp.2025.114675
PG 17
WC Immunology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Pharmacology & Pharmacy
GA 2EV8Y
UT WOS:001480977400001
PM 40286785
DA 2025-06-11
ER

PT J
AU Podvin, S
   Bundey, R
   Toneff, T
   Ziegler, M
   Hook, V
AF Podvin, Sonia
   Bundey, Richard
   Toneff, Thomas
   Ziegler, Michael
   Hook, Vivian
TI Profiles of secreted neuropeptides and catecholamines illustrate
   similarities and differences in response to stimulation by distinct
   secretagogues
SO MOLECULAR AND CELLULAR NEUROSCIENCE
LA English
DT Article
DE Neurotransmitter profiles; Secretion; Catecholamines; Neuropeptides;
   Secretagogues; Chromaffin cells; Stress response
ID ADRENAL CHROMAFFIN CELLS; QUANTITATIVE-ANALYSIS; NEUROENDOCRINE CELLS;
   STRESS TRANSDUCTION; METABOLIC SYNDROME; NEUROTRANSMITTER; VESICLES;
   MEDULLA; EXPRESSION; HISTAMINE
AB The goal of this study was to define profiles of secreted neuropeptide and catecholamine neurotransmitters that undergo co-release from sympathoadrenal chromaffin cells upon stimulation by distinct secretagogues. Chromaffin cells of the adrenal medulla participate in the dynamic responses to stress, especially that of 'fight and flight', and, thus, analyses of the co-release of multiple neurotransmitters is necessary to gain knowledge of how the stress response regulates cell-cell communication among physiological systems. Results of this study demonstrated that six different secretagogues stimulated the co-release of the neuropeptides Met-enkephalin, galanin, NPY, and VIP with the catecholamines dopamine, norepinephrine, and epinephrine. Importantly, the quantitative profiles of the secreted neurotransmitters showed similarities and differences upon stimulation by the different secretagogues evaluated, composed of KCl depolarization, nicotine, carbachol, PACAP, bradykinin, and histamine. The rank-orders of the secreted profiles of the neurotransmitters were generally similar among these secretagogues, but differences in the secreted amounts of each neurotransmitter occurred with different secretagogues. Epinephrine among the catecholamines showed the highest level of secretion. (Met)enkephalin showed the largest levels of secretion compared to the other neuropeptides examined. Levels of secreted catecholamines were greater than that of the neuropeptides. These data support the hypothesis that profiles of secreted neuropeptide and catecholamine neurotransmitters show similarities and differences upon stimulation by distinct secretagogues. These results illustrate the co-release of concerted neurotransmitter profiles that participate in the stress response of the sympathoadrenal nervous system. (C) 2015 Elsevier Inc. All rights reserved.
C1 [Podvin, Sonia; Toneff, Thomas; Hook, Vivian] Univ Calif San Diego, Skaggs Sch Pharm & Pharmaceut Sci, La Jolla, CA 92093 USA.
   [Bundey, Richard; Ziegler, Michael] Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA.
   [Hook, Vivian] Univ Calif San Diego, Dept Neurosci, Sch Med, La Jolla, CA 92093 USA.
   [Hook, Vivian] Univ Calif San Diego, Dept Pharmacol, Sch Med, La Jolla, CA 92093 USA.
C3 University of California System; University of California San Diego;
   University of California System; University of California San Diego;
   University of California System; University of California San Diego;
   University of California System; University of California San Diego
RP Hook, V (corresponding author), Univ Calif San Diego, Skaggs Sch Pharm & Pharmaceut Sci, 9500 Gilman Dr 0744, La Jolla, CA 92093 USA.
EM vhook@ucsd.edu
RI Ziegler, Michael/L-4728-2019
FU NIH [R01MH077305, R01DA04275, P01HL58120, T32DA07315, T32DA7315]
FX This research was supported by NIH grants to V. Hook (R01MH077305,
   R01DA04275, P01HL58120, and T32DA07315) and M. Ziegler (P01HL58120). S.
   Podvin was a postdoctoral scholar supported by NIH grant T32DA7315.
   Technical assistance by B. Kennedy and J. Pottenger was appreciated.
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NR 55
TC 20
Z9 28
U1 0
U2 7
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 1044-7431
EI 1095-9327
J9 MOL CELL NEUROSCI
JI Mol. Cell. Neurosci.
PD SEP
PY 2015
VL 68
BP 177
EP 185
DI 10.1016/j.mcn.2015.06.008
PG 9
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA CU2MO
UT WOS:000363357800016
PM 26092702
OA Green Submitted, Green Accepted
DA 2025-06-11
ER

PT J
AU Chan, KH
   Lam, KSL
   Cheng, OY
   Kwan, JSC
   Ho, PWL
   Cheng, KKY
   Chung, SK
   Ho, JWM
   Guo, VY
   Xu, A
AF Chan, Koon-Ho
   Lam, Karen Siu-Ling
   Cheng, On-Yin
   Kwan, Jason Shing-Cheong
   Ho, Philip Wing-Lok
   Cheng, Kenneth King-Yip
   Chung, Sookja Kim
   Ho, Jessica Wing-Man
   Guo, Vivian Yawei
   Xu, Almin
TI Adiponectin is Protective against Oxidative Stress Induced Cytotoxicity
   in Amyloid-Beta Neurotoxicity
SO PLOS ONE
LA English
DT Article
ID NF-KAPPA-B; ACTIVATED PROTEIN-KINASE; NEUROBLASTOMA SH-SY5Y CELLS;
   GROWTH-FACTOR EXPRESSION; ALZHEIMERS-DISEASE; NEURODEGENERATIVE DISEASE;
   METABOLIC SYNDROME; PRECURSOR PROTEIN; GENE-EXPRESSION; MOUSE MODEL
AB Beta-amyloid (A beta) neurotoxicity is important in Alzheimer's disease (AD) pathogenesis. Ab neurotoxicity causes oxidative stress, inflammation and mitochondrial damage resulting in neuronal degeneration and death. Oxidative stress, inflammation and mitochondrial failure are also pathophysiological mechanisms of type 2 diabetes (T2DM) which is characterized by insulin resistance. Interestingly, T2DM increases risk to develop AD which is associated with reduced neuronal insulin sensitivity (central insulin resistance). We studied the potential protective effect of adiponectin (an adipokine with insulin-sensitizing, anti-inflammatory and anti-oxidant properties) against A beta neurotoxicity in human neuroblastoma cells (SH-SY5Y) transfected with the Swedish amyloid precursor protein (Sw-APP) mutant, which overproduced A beta with abnormal intracellular A beta accumulation. Cytotoxicity was measured by assay for lactate dehydrogenase (LDH) released upon cell death and lysis. Our results revealed that Sw-APP transfected SH-SY5Y cells expressed both adiponectin receptor 1 and 2, and had increased AMP-activated protein kinase (AMPK) activation and enhanced nuclear factor-kappa B (NF-kappa B) activation compared to control empty-vector transfected SH-SY5Y cells. Importantly, adiponectin at physiological concentration of 10 mu g/ml protected Sw-APP transfected SH-SY5Y cells against cytotoxicity under oxidative stress induced by hydrogen peroxide. This neuroprotective action of adiponectin against A beta neurotoxicity-induced cytotoxicity under oxidative stress involved 1) AMPK activation mediated via the endosomal adaptor protein APPL1 (adaptor protein with phosphotyrosine binding, pleckstrin homology domains and leucine zipper motif) and possibly 2) suppression of NF-kappa B activation. This raises the possibility of novel therapies for AD such as adiponectin receptor agonists.
C1 [Chan, Koon-Ho; Lam, Karen Siu-Ling; Cheng, On-Yin; Kwan, Jason Shing-Cheong; Ho, Philip Wing-Lok; Cheng, Kenneth King-Yip; Ho, Jessica Wing-Man; Guo, Vivian Yawei; Xu, Almin] Univ Hong Kong, LKS Fac Med, Univ Dept Med, Hong Kong, Hong Kong, Peoples R China.
   [Chan, Koon-Ho; Lam, Karen Siu-Ling; Ho, Philip Wing-Lok; Cheng, Kenneth King-Yip; Xu, Almin] Univ Hong Kong, LKS Fac Med, Res Ctr Heart Brain Hormone & Hlth Aging, Hong Kong, Hong Kong, Peoples R China.
   [Chan, Koon-Ho; Lam, Karen Siu-Ling; Chung, Sookja Kim] Univ Hong Kong, LKS Fac Med, Hong Kong Univ Alzheimers Dis Res Network, Hong Kong, Hong Kong, Peoples R China.
   [Chan, Koon-Ho; Cheng, On-Yin; Kwan, Jason Shing-Cheong] Univ Hong Kong, LKS Fac Med, Neuroimmunol & Neuroinflammat Res Lab, Hong Kong, Hong Kong, Peoples R China.
C3 University of Hong Kong; University of Hong Kong; University of Hong
   Kong; University of Hong Kong
RP Chan, KH (corresponding author), Univ Hong Kong, LKS Fac Med, Univ Dept Med, Hong Kong, Hong Kong, Peoples R China.
EM koonho@hkucc.hku.hk
RI Chan, Koon/C-4208-2009; Cheng, Yip/C-4551-2009; Xu, Aimin/D-3291-2013;
   Guo, Vivian/ABB-5803-2022; /C-4315-2009; Ho, Philip Wing-Lok/K-5814-2013
OI /0000-0001-5757-541X; /0000-0003-4665-2576; Cheng, Kenneth King
   Yip/0000-0002-7274-0839; Ho, Philip Wing-Lok/0000-0001-7794-0146; Guo,
   Vivian Yawei/0000-0001-9399-1808
FU Hong Kong University Alzheimer's Disease Research Network; LKS Faculty
   of Medicine of the University of Hong Kong
FX This study is supported by funding from the Hong Kong University
   Alzheimer's Disease Research Network and Seed Funding for Basic Research
   from the LKS Faculty of Medicine of the University of Hong Kong. The
   funders had no role in study design, data collection and analysis,
   decision to publish, or preparation of the manuscript.
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NR 85
TC 119
Z9 130
U1 1
U2 21
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD DEC 27
PY 2012
VL 7
IS 12
AR e52354
DI 10.1371/journal.pone.0052354
PG 12
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 061EA
UT WOS:000312829100044
PM 23300647
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Zhang, RJ
   Liu, HW
   Bai, H
   Zhang, YJ
   Liu, QQ
   Guan, LB
   Fan, P
AF Zhang, Renjiao
   Liu, Hongwei
   Bai, Huai
   Zhang, Yujin
   Liu, Qingqing
   Guan, Linbo
   Fan, Ping
TI Oxidative stress status in Chinese women with different clinical
   phenotypes of polycystic ovary syndrome
SO CLINICAL ENDOCRINOLOGY
LA English
DT Article
ID HORMONE REPLACEMENT THERAPY; ABDOMINAL ADIPOSITY; INSULIN-RESISTANCE;
   METABOLIC SYNDROME; SYNDROME PCOS; PARAOXONASE 1; ENDOCRINE; PROFILE;
   HYPERGLYCEMIA; LIPOPROTEIN
AB Objective To determine oxidative stress status and its association with clinical and metabolic parameters in Chinese women with different clinical phenotypes of polycystic ovary syndrome (PCOS).
   Design A cross-sectional study.
   Patients A total of 544 patients with PCOS and 468 control women were included.
   Measurements The total oxidant status (TOS) was determined using a microplate colorimetric method. Total antioxidant capacity (T-AOC), oxidative stress index (OSI, the ratios of TOS to T-AOC) and clinical, hormonal and metabolic parameters were also analysed.
   Results TOS and OSI were significantly higher in each of the four PCOS phenotypes based on the Rotterdam criteria than in the control women and higher in patients with hyperandrogenism (HA) than in those without HA (P < 0.05). TOS, T-AOC and OSI were higher in lean patients than in lean controls (P < 0.05). These values, except OSI, were also higher in overweight/obese patients than in lean patients, and lean or overweight/obese controls (P < 0.05). Multivariate regression analysis demonstrated that apolipoprotein (apo) A1, the Ferriman-Gallwey score, triglyceride (TG), oestradiol (E-2), high-density lipoprotein cholesterol (HDL-C) and 2-h glucose levels were the main predictors of TOS; the Ferriman-Gallwey score, E-2, apoA1, TG and HDL-C levels were the main predictors of OSI.
   Conclusions Patients with PCOS with HA have higher oxidative stress levels compared with those without HA. The increased oxidative stress in PCOS is related to HA status, increased plasma glucose, TG, HDL-C and E2 levels, decreased apoA1 concentrations and a relative shortage of antioxidant capacity.
C1 [Zhang, Renjiao; Bai, Huai; Liu, Qingqing; Guan, Linbo; Fan, Ping] Sichuan Univ, West China Second Univ Hosp, Key Lab Birth Defects & Related Dis Women & Child, Minist Educ,Lab Genet Dis & Perinatal Med, Chengdu, Peoples R China.
   [Liu, Hongwei; Zhang, Yujin] Sichuan Univ, West China Second Univ Hosp, Dept Obstet & Gynecol, Chengdu, Peoples R China.
C3 Sichuan University; Ministry of Education - China; Sichuan University
RP Fan, P (corresponding author), Sichuan Univ, West China Hosp 2, Lab Genet Dis & Perinatal Med, Chengdu 610041, Sichuan, Peoples R China.
EM fanping15@scu.edu.cn
RI liu, qingqing/HHD-0360-2022
FU Chinese National Natural Science Foundation [81370681]; Program for
   Changjiang Scholars and Innovative Research Team in University, Ministry
   of Education [IRT0935]
FX The authors have no conflict of interests to disclose. This work was
   supported by the Chinese National Natural Science Foundation (grant
   number 81370681) and the Program for Changjiang Scholars and Innovative
   Research Team in University, Ministry of Education (grant number
   IRT0935).
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NR 35
TC 67
Z9 74
U1 0
U2 14
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0300-0664
EI 1365-2265
J9 CLIN ENDOCRINOL
JI Clin. Endocrinol.
PD JAN
PY 2017
VL 86
IS 1
BP 88
EP 96
DI 10.1111/cen.13171
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA EJ8CZ
UT WOS:000393453400012
PM 27489079
DA 2025-06-11
ER

PT J
AU Wang, HF
   Steffen, LM
   Vessby, B
   Basu, S
   Steinberger, J
   Moran, A
   Jacobs, DR
   Hong, CP
   Sinaiko, AR
AF Wang, Huifen
   Steffen, Lyn M.
   Vessby, Bengt
   Basu, Samar
   Steinberger, Julia
   Moran, Antoinette
   Jacobs, David R., Jr.
   Hong, Ching-Ping
   Sinaiko, Alan R.
TI Obesity Modifies the Relations Between Serum Markers of Dairy Fats and
   Inflammation and Oxidative Stress Among Adolescents
SO OBESITY
LA English
DT Article
ID CATALYZED LIPID-PEROXIDATION; CARDIOVASCULAR RISK-FACTORS; C-REACTIVE
   PROTEIN; ACID-COMPOSITION; MILK-FAT; MYOCARDIAL-INFARCTION; METABOLIC
   SYNDROME; HEALTHY-SUBJECTS; ADIPOSE-TISSUE; PLASMA
AB Pentadecanoic acid (15: 0) and heptadecanoic acid (17: 0), the dairy-specific saturated fatty acids have been inversely, while inflammation and oxidative stress have been positively related to the risk of cardiovascular disease (CVD). Both fatty acid metabolism and inflammation and oxidative stress may be influenced by adiposity. In the current cross-sectional analyses among adolescents (mean age 15 years), we determined whether overweight status modified the associations between dairy fatty acids (pentadecanoic acid (15: 0) and heptadecanoic acid (17: 0)) represented in serum phospholipids (PL) and markers of inflammation and oxidative stress. Six biomarkers for inflammation and oxidative stress were analyzed, including circulating adiponectin, C-reactive protein (CRP), cytokines interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha), and urinary 15-keto-dihydro-PGF2 alpha (15-keto) and 8-iso-PGF2 alpha (F2-iso). Generalized linear regression analyses, adjusted for age, gender, race, tanner score, total energy intake and physical activity, revealed that PL dairy fatty acids were inversely associated with CRP, F2-iso and 15-keto in overweight, but not in normal weight adolescents (all P-interaction < 0.05). However, higher level of PL dairy fatty acids was associated with lower IL-6 among all adolescents. Further adjustment for dietary intake of calcium, vitamin D, protein, total flavonoids, and omega-3 fatty acids did not materially change the findings. Dairy-specific saturated fats, i.e., 15: 0 and 17: 0 fatty acids, may contribute to the potential health benefits of dairy products, especially for overweight adolescents.
C1 [Wang, Huifen; Steffen, Lyn M.; Jacobs, David R., Jr.; Hong, Ching-Ping] Univ Minnesota, Sch Publ Hlth, Div Epidemiol & Community Hlth, Minneapolis, MN 55455 USA.
   [Wang, Huifen; Steffen, Lyn M.] Univ Minnesota, Dept Food Sci & Nutr, St Paul, MN USA.
   [Vessby, Bengt] Uppsala Univ, Fac Med, Dept Publ Hlth & Caring Sci, Sect Clin Nutr & Metab, Uppsala, Sweden.
   [Steinberger, Julia; Moran, Antoinette; Sinaiko, Alan R.] Univ Minnesota, Sch Med, Dept Pediat, Minneapolis, MN 55455 USA.
   [Jacobs, David R., Jr.] Univ Oslo, Dept Nutr, Oslo, Norway.
C3 University of Minnesota System; University of Minnesota Twin Cities;
   University of Minnesota System; University of Minnesota Twin Cities;
   Uppsala University; University of Minnesota System; University of
   Minnesota Twin Cities; University of Oslo
RP Steffen, LM (corresponding author), Univ Minnesota, Sch Publ Hlth, Div Epidemiol & Community Hlth, Minneapolis, MN 55455 USA.
EM steffen@epi.umn.edu
RI Wang, Huifen/G-8471-2012; Jacobs, David/G-5405-2011
OI Jacobs, David/0000-0002-7232-0543; Steffen, Lyn M/0000-0002-4053-6729;
   Steinberger, Julia/0000-0002-2892-8594
FU National Institutes of Health [HL52851, MO1RR00400]
FX H.W., L.M.S., A.R.S. designed research; H.W., L.M.S., B.V., S.B., J.S.,
   A.M., A.R.S. conducted research; B.V., S.B., D.R.J., C.P.H. provided
   essential materials; H.W., L.M.S., C.P.H. analyzed data; H.W., L.M.S.,
   B.V., S.B., J.S., A.M., D.R.J., A.R.S. wrote the paper. L.M.S., A.R.S.
   had primary responsibility for final content. All authors read and
   approved the final manuscript. This study was funded by the National
   Institutes of Health by grants #HL52851 and #MO1RR00400.
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NR 46
TC 41
Z9 47
U1 0
U2 20
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1930-7381
EI 1930-739X
J9 OBESITY
JI Obesity
PD DEC
PY 2011
VL 19
IS 12
BP 2404
EP 2410
DI 10.1038/oby.2011.234
PG 7
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 853EM
UT WOS:000297409000017
PM 21779090
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Sharma, A
   Tate, M
   Mathew, G
   Vince, JE
   Ritchie, RH
   de Haan, JB
AF Sharma, Arpeeta
   Tate, Mitchel
   Mathew, Geetha
   Vince, James E.
   Ritchie, Rebecca H.
   de Haan, Judy B.
TI Oxidative Stress and NLRP3-Inflammasome Activity as Significant Drivers
   of Diabetic Cardiovascular Complications: Therapeutic Implications
SO FRONTIERS IN PHYSIOLOGY
LA English
DT Review
DE NLRP3 inflammasome; diabetic nephropathy; diabetic atherosclerosis;
   diabetic cardiomyopathy; inflammation; inflammatory cytokines; oxidative
   stress; diabetic complications
ID NLRP3 INFLAMMASOME ACTIVATION; METABOLIC SYNDROME; SUBCLINICAL
   ATHEROSCLEROSIS; CARDIAC FIBROBLASTS; INSULIN-RESISTANCE; GASDERMIN D;
   CELL-DEATH; OBESITY; INTERLEUKIN-18; DISEASE
AB It is now increasingly appreciated that inflammation is not limited to the control of pathogens by the host, but rather that sterile inflammation which occurs in the absence of viral or bacterial pathogens, accompanies numerous disease states, none more so than the complications that arise as a result of hyperglycaemia. Individuals with type 1 or type 2 diabetes mellitus (T1D, T2D) are at increased risk of developing cardiac and vascular complications. Glucose and blood pressure lowering therapies have not stopped the advance of these morbidities that often lead to fatal heart attacks and/or stroke. A unifying mechanism of hyperglycemia-induced cellular damage was initially proposed to link elevated blood glucose levels with oxidative stress and the dysregulation of metabolic pathways. Pre-clinical evidence has, in most cases, supported this notion. However, therapeutic strategies to lessen oxidative stress in clinical trials has not proved efficacious, most likely due to indiscriminate targeting by antioxidants such as vitamins. Recent evidence now suggests that oxidative stress is a major driver of inflammation and vice versa, with the latest findings suggesting not only a key role for inflammatory pathways underpinning metabolic and haemodynamic dysfunction in diabetes, but furthermore that these perturbations are driven by activation of the NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome. This review will address these latest findings with an aim of highlighting the interconnectivity between oxidative stress, NLRP3 activation and inflammation as it pertains to cardiac and vascular injury sustained by diabetes. Current therapeutic strategies to lessen both oxidative stress and inflammation will be emphasized. This will be placed in the context of improving the burden of these diabetic complications.
C1 [Sharma, Arpeeta; de Haan, Judy B.] Baker Heart & Diabet Inst, Oxidat Stress Lab, Basic Sci Domain, Melbourne, Vic, Australia.
   [Tate, Mitchel; Ritchie, Rebecca H.] Baker Heart & Diabet Inst, Heart Failure Pharmacol Lab, Basic Sci Domain, Melbourne, Vic, Australia.
   [Mathew, Geetha] Westmead Hosp, Cellular Therapies Lab, Sydney, NSW, Australia.
   [Vince, James E.] Walter & Eliza Hall Inst Med Res, Inflammat Div, Melbourne, Vic, Australia.
   [Vince, James E.] Univ Melbourne, Dept Med Biol, Melbourne, Vic, Australia.
C3 NSW Health; Westmead Hospital; University of Sydney; University of
   Melbourne
RP de Haan, JB (corresponding author), Baker Heart & Diabet Inst, Oxidat Stress Lab, Basic Sci Domain, Melbourne, Vic, Australia.
EM judy.dehaan@baker.edu.au
RI Ritchie, Rebecca/E-7392-2011; de Haan, Judy/E-8778-2010
OI Sharma, Arpeeta/0000-0003-2052-5931; Tate, Mitchel/0000-0003-1422-1747;
   Ritchie, Rebecca/0000-0002-8610-0058; Mathew,
   Geetha/0000-0002-2154-2672; de Haan, Judy B./0000-0002-2749-7833
FU National Health and Medical Research Council (NHMRC) of Australia
   [APP1045140, APP1101405, GNT1091003]; Victorian Government's Operational
   Infrastructure Support Program; Reata Pharmaceuticals; Baker Fellowship
FX This work was supported in part by both the National Health and Medical
   Research Council (NHMRC) of Australia, including APP1045140 (to RR),
   APP1101405 (to JV), and GNT1091003 (to AS), and the Victorian
   Government's Operational Infrastructure Support Program. RR is an NHMRC
   Senior Research Fellow (APP1059960). JdH acknowledges support from Reata
   Pharmaceuticals and a Baker Fellowship.
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NR 135
TC 157
Z9 173
U1 2
U2 48
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1664-042X
J9 FRONT PHYSIOL
JI Front. Physiol.
PD FEB 20
PY 2018
VL 9
AR 114
DI 10.3389/fphys.2018.00114
PG 15
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA FW7TX
UT WOS:000425529100002
PM 29515457
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Pageau, LM
   Ng, TJ
   Ling, JY
   Given, BA
   Robbins, LB
   Deka, P
   Schlegel, EC
AF Pageau, Lauren M.
   Ng, Teresa J.
   Ling, Jiying
   Given, Barbara A.
   Robbins, Lorraine B.
   Deka, Pallav
   Schlegel, Emma C.
TI Associations between hair cortisol and blood pressure: a systematic
   review and meta-analysis
SO JOURNAL OF HYPERTENSION
LA English
DT Review
DE blood pressure; hair cortisol; hypertension; meta-analysis; stress
ID METABOLIC SYNDROME; HPA AXIS; STRESS; DETERMINANTS
AB Objective:Stress is widely considered to be a risk factor for high blood pressure (BP), but evidence on the associations between biomarkers of chronic stress and BP is inconsistent. This systematic review and meta-analysis assessed the current state of the science on relationships between measures of cortisol concentration reflecting chronic stress exposure [hair cortisol concentration (HCC), nail cortisol concentration)] and BP.Methods:PubMed, Cumulative Index to Nursing and Allied Health Literature, Web of Science, Cochrane Library, and Embase were searched. Random effects models were used to assess the pooled effect size. Exploratory moderation analysis was performed.Results:Out of 34 014 identified, 16 articles met eligibility criteria and were included in the review, while 14 were included in the meta-analysis. No articles were reported on the association between nail cortisol concentration and BP. Small, positive associations were observed between HCC and SBP [r = 0.19 (95% confidence interval (CI): 0.08-0.29)] and HCC and DBP [r = 0.13 (95% CI: 0.04-0.22)]. Cortisol analysis method was identified as a significant moderator of the association between HCC and DBP. HCC was largely, positively associated with hypertension status [odds ratio = 3.23 (95% CI: 2.55-4.09), P Conclusions:Current evidence suggests that higher HCC may be associated with elevated BP and a potential risk factor for hypertension. However, results should be interpreted with caution because HCC can be affected by hair color, hair care products, and analytic methods. Given the limitations of studies included in this review, further research is needed.
C1 [Pageau, Lauren M.; Ng, Teresa J.; Ling, Jiying; Given, Barbara A.; Robbins, Lorraine B.; Deka, Pallav; Schlegel, Emma C.] Michigan State Univ, Coll Nursing, E Lansing, MI USA.
   [Pageau, Lauren M.] Michigan State Univ, 1355 Bogue St, E Lansing, MI 48824 USA.
C3 Michigan State University; Michigan State University
RP Pageau, LM (corresponding author), Michigan State Univ, 1355 Bogue St, E Lansing, MI 48824 USA.
EM pageaula@msu.edu
RI Pageau, Lauren/JZT-9021-2024; Schlegel, Emma/AAW-7105-2021; Ling,
   Jiying/R-5914-2019
OI Schlegel, Emma/0000-0002-0242-6561; Ng, Teresa/0000-0002-3961-5171
FU Dissertation Completion Fellowship at Michigan State University
FX The authors would like to thank Jessica Sender, master's prepared health
   sciences librarian at Michigan State University, for assisting with
   developing the literature search strategy. The authors would also like
   to thank Drishti Chauhan, Nandini Koneru, and Meghana Jalagam for
   assisting with title and abstract screening. The current review was
   supported by the Dissertation Completion Fellowship at Michigan State
   University.
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U2 8
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0263-6352
EI 1473-5598
J9 J HYPERTENS
JI J. Hypertens.
PD JUN
PY 2023
VL 41
IS 6
BP 875
EP 887
DI 10.1097/HJH.0000000000003412
PG 13
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA F4FH6
UT WOS:000981915300004
PM 37016924
DA 2025-06-11
ER

PT J
AU Joubert, MBV
   Ingaramo, P
   Oliva, ME
   D'Alessandro, ME
AF Vega Joubert, Michelle Berenice
   Ingaramo, Paola
   Eugenia Oliva, Maria
   Eugenia D'Alessandro, Maria
TI Salvia hispanica L. (chia) seed ameliorates liver injury and
   oxidative stress by modulating NrF2 and NFκB expression in sucrose-rich
   diet-fed rats
SO FOOD & FUNCTION
LA English
DT Article
ID ADIPOSE-TISSUE DYSFUNCTION; INSULIN-RESISTANCE; INFLAMMATORY CYTOKINES;
   LIPID-METABOLISM; ACID; DYSLIPIDEMIA
AB The aim of this study was to analyze the liver injury and oxidative stress in an experimental model of Metabolic Syndrome (MS) induced by chronic administration of a sucrose-rich diet (SRD) and to evaluate the effects of chia seed as a therapeutic strategy. Male Wistar rats were fed with a reference diet (RD) -6 months- or a SRD -3 months. Then, the latter group was randomly divided into two subgroups. One subgroup continued receiving the SRD for up to 6 months and the other was fed with a SRD where whole chia seed was incorporated as a source of dietary fat for the next 3 months (SRD+CHIA). The results showed that rats fed with a SRD for a long period of time developed dyslipidemia, hyperglycemia, hepatic lipid accumulation, liver injury, hepatic lipid peroxidation and oxidative stress. Hepatic NrF2 expression was significantly decreased. In addition, a significant increase in hepatic NF kappa B p65 expression and a positive correlation of this with plasma TNF alpha levels were found. The administration of chia seed for 3 months reversed dyslipidemia, hyperglycemia, lipid accumulation, liver injury, lipid peroxidation and oxidative stress. In the liver tissue, NrF2 expression was normalized and NF kappa B p65 expression was decreased, the latter was associated with a decrease in plasma TNF alpha levels. The present study showed new aspects of liver damage, lipid peroxidation and oxidative stress in dyslipidemic insulin resistant rats chronically fed with a sucrose-rich diet. However, we demonstrated new properties and molecular mechanisms associated with the beneficial anti-oxidant effects of chia seed consumption.
C1 [Vega Joubert, Michelle Berenice; Eugenia Oliva, Maria; Eugenia D'Alessandro, Maria] Univ Nacl Litoral, Fac Bioquim & Ciencias Biol, Lab Estudio Enfermedades Metab Relacionadas Nutr, Consejo Nacl Invest Cient & Tecn CONICET, Santa Fe, Argentina.
   [Ingaramo, Paola] Consejo Nacl Invest Cient & Tecn CONICET, Inst Salud & Ambiente Litoral ISAL, Fac Bioquim & Cs Biol, Santa Fe, Argentina.
C3 Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET);
   National University of the Littoral; Consejo Nacional de Investigaciones
   Cientificas y Tecnicas (CONICET)
RP Oliva, ME; D'Alessandro, ME (corresponding author), Univ Nacl Litoral, Fac Bioquim & Ciencias Biol, Lab Estudio Enfermedades Metab Relacionadas Nutr, Consejo Nacl Invest Cient & Tecn CONICET, Santa Fe, Argentina.
EM meoliva@fbcb.unl.edu.ar; medaless@fbcb.unl.edu.ar
RI Oliva, Maria/IUM-4089-2023
OI Vega Joubert, Michelle Berenice/0000-0002-8310-7844; Oliva, Maria
   Eugenia/0000-0002-4368-4102
FU Fondo para la Investigacion Cientifica y Tecnologica, Argentina, Grant
   PICT [2018-01344]; Universidad Nacional del Litoral, Argentina [CAI+D]
   [50620190100008LI]; Forte [2018-01344] Funding Source: Forte
FX The authors would like to thank Silvia Rodriguez for skillful technical
   assistance. This work was supported by Fondo para la Investigacion
   Cientifica y Tecnologica, Argentina, Grant PICT #2018-01344 and
   Universidad Nacional del Litoral, Argentina [CAI+D #50620190100008LI].
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U1 1
U2 5
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PD JUL 4
PY 2022
VL 13
IS 13
BP 7333
EP 7345
DI 10.1039/d2fo00642a
EA MAY 2022
PG 13
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA 2Q3ZB
UT WOS:000813575800001
PM 35726830
DA 2025-06-11
ER

PT J
AU Li, L
   Meng, F
   Li, N
   Zhang, L
   Wang, J
   Wang, H
   Li, D
   Zhang, X
   Dong, P
   Chen, Y
AF Li, L.
   Meng, F.
   Li, N.
   Zhang, L.
   Wang, J.
   Wang, H.
   Li, D.
   Zhang, X.
   Dong, P.
   Chen, Y.
TI Exercise training prevents the attenuation of anesthetic
   pre-conditioning-mediated cardioprotection in diet-induced obese rats
SO ACTA ANAESTHESIOLOGICA SCANDINAVICA
LA English
DT Article
ID ISCHEMIA-REPERFUSION INJURY; METABOLIC SYNDROME; OXIDATIVE STRESS;
   UP-REGULATION; INFARCT SIZE; DYSFUNCTION; IMPACT; MODEL; RISK
AB BackgroundObesity abolishes anesthetic pre-conditioning-induced cardioprotection due to impaired reactive oxygen species (ROS)-mediated adenosine monophosphate-activated protein kinase (AMPK) pathway, a consequence of increased basal myocardial oxidative stress. Exercise training has been shown to attenuate obesity-related oxidative stress.
   ObjectiveThis study tests whether exercise training could normalize ROS-mediated AMPK pathway and prevent the attenuation of anesthetic pre-conditioning-induced cardioprotection in obesity.
   MethodsMale Sprague-Dawley rats were divided into lean rats fed with control diet and obese rats fed with high-fat diet. After 4 weeks of feeding, lean and obese rats were assigned to sedentary conditions or treadmill exercise for 8 weeks.
   ResultsThere was no difference in infarct size between lean sedentary and obese sedentary rats after 25min of myocardial ischemia followed by 120min reperfusion. In lean rats, sevoflurane equally reduced infarct size in lean sedentary and lean exercise-trained rats. Molecular studies revealed that AMPK activity, endothelial nitric oxide synthase, and superoxide production measured at the end of ischemia in lean rats were increased in response to sevoflurane. In obese rats, sevoflurane increased the above molecular parameters and reduced infarct size in obese exercise-trained rats but not in obese sedentary rats. Additional study showed that obese exercise-trained rats had decreased basal oxidative stress than obese sedentary rats.
   ConclusionThe results indicate that exercise training can prevent the attenuation of anesthetic cardioprotection in obesity. Preventing the attenuation of this strategy may be associated with reduced basal oxidative stress and normalized ROS-mediated AMPK pathway, but the causal relationship remains to be determined.
C1 [Li, L.; Zhang, L.; Wang, H.; Li, D.; Zhang, X.; Dong, P.] Shandong Univ, Qilu Hosp, Dept Anesthesiol, Jinan, Shandong, Peoples R China.
   [Meng, F.] Jinan Matern & Childcare Hosp, Dept Anesthesiol, Jinan, Shandong, Peoples R China.
   [Li, N.] Jining Med Univ, Sch Publ Hlth, Jinan, Shandong, Peoples R China.
   [Wang, J.; Chen, Y.] Shandong Univ, Qilu Hosp, Dept Emergency, Jinan, Shandong, Peoples R China.
C3 Shandong University; Jining Medical University; Shandong University
RP Chen, Y (corresponding author), Shandong Univ, Qilu Hosp, Dept Emergency, Jinan, Shandong, Peoples R China.
EM yuguo-chen-sdu@hotmail.com
RI Zhang, Xinxin/HZJ-1742-2023
FU National Natural Science Foundation of China [81170136, 81100147,
   81300103, 81300219]; Specialized Research Fund for the Doctoral Program
   of Higher Education [20130131110048]; National 973 Basic Research
   Program of China [2010CB732605]; Taishan Scholar Program of Shandong
   Province; Department of Science and Technology of Shandong Province
   [2011GSF11806]; Shandong Provincial Outstanding Medical Academic
   Professional Program; 1020 Program from the Health Department of
   Shandong Province
FX This study was supported by the National Natural Science Foundation of
   China (81170136, 81100147, 81300103, 81300219), Specialized Research
   Fund for the Doctoral Program of Higher Education (20130131110048), the
   National 973 Basic Research Program of China (2010CB732605), Taishan
   Scholar Program of Shandong Province, Grant from Department of Science
   and Technology of Shandong Province (2011GSF11806), Shandong Provincial
   Outstanding Medical Academic Professional Program, 1020 Program from the
   Health Department of Shandong Province.
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NR 37
TC 10
Z9 11
U1 0
U2 14
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0001-5172
EI 1399-6576
J9 ACTA ANAESTH SCAND
JI Acta Anaesthesiol. Scand.
PD JAN
PY 2015
VL 59
IS 1
BP 85
EP 97
DI 10.1111/aas.12414
PG 13
WC Anesthesiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Anesthesiology
GA AW9NA
UT WOS:000346583000009
PM 25312305
DA 2025-06-11
ER

PT J
AU Delaigle, AM
   Senou, M
   Guiot, Y
   Many, MC
   Brichard, SM
AF Delaigle, AM
   Senou, M
   Guiot, Y
   Many, MC
   Brichard, SM
TI Induction of adiponectin in skeletal muscle of type 2 diabetic mice: in
   vivo and in vitro studies
SO DIABETOLOGIA
LA English
DT Article
DE adiponectin; obesity; oxidative stress; skeletal muscle; type 2 diabetes
ID FATTY-ACID OXIDATION; ACTIVATED PROTEIN-KINASE; ADIPOSE-SPECIFIC
   PROTEIN; OB-OB MICE; PLASMA-CONCENTRATIONS; GLUCOSE-UTILIZATION;
   METABOLIC SYNDROME; DEPENDENT PATHWAY; GENE-EXPRESSION; OB/OB MICE
AB Aims/hypothesis: Adiponectin is an adipokine that exhibits insulin-sensitising, fat-burning and anti-inflammatory properties as well as modulatory effects on oxidative stress. We examined whether adiponectin could be induced in a non-adipose tissue, skeletal muscle, in response to metabolic or oxidative aggression both in vivo (in a murine model of type 2 diabetes) and in vitro. Methods: Obese and diabetic ob/ob mice were used and compared with lean littermates. Some obese mice were treated with the antioxidant probucol for 3 weeks. At the end of the experiment, blood was sampled and tibialis anterior muscles were collected for mRNA measurement and immunohistochemistry. Additional in vitro experiments were performed on C2C12 myotubes cultured for up to 48 h. Results: In spite of hypoadiponectinaemia, Adipoq mRNA levels were markedly increased in the skeletal muscle of ob/ob mice and correlated with systemic oxidative stress. Adipoq upregulation was shown in laser-microdissected myocytes of obese mice. Concomitantly, immunoreactivity for adiponectin was enhanced in obese muscle fibres together with lipid infiltration and local markers of oxidative stress. In cultured C2C12 myotubes, a triglyceride mix and reactive oxygen species producers (H2O2 or a lipoperoxidation end-product) upregulated Adipoq expression and adiponectin production. This effect was reversed by an antioxidant. Finally, treatment of obese mice with probucol also attenuated upregulation in muscle. Conclusions/interpretation: The paradoxical upregulation of adiponectin in muscle of obese and diabetic mice may result from lipotoxicity and related oxidative stress. This unexpected finding could be viewed as a local protection to counteract ectopic fat deposition and oxidative damage.
C1 Univ Louvain, Fac Med, Endocrinol & Metab Unit, Brussels, Belgium.
   Univ London, Fac Med, Expt Morphol Unit, Brussels, Belgium.
   Univ Louvain, Fac Med, Pathol Univ, Brussels, Belgium.
C3 Universite Catholique Louvain; Universite Catholique Louvain
RP Univ Louvain, Fac Med, Endocrinol & Metab Unit, Brussels, Belgium.
EM brichard@endo.ucl.ac.be
RI Brichard, Sonia/B-4597-2013
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NR 44
TC 71
Z9 76
U1 0
U2 7
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0012-186X
EI 1432-0428
J9 DIABETOLOGIA
JI Diabetologia
PD JUN
PY 2006
VL 49
IS 6
BP 1311
EP 1323
DI 10.1007/s00125-006-0210-y
PG 13
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 039WV
UT WOS:000237339700026
PM 16570160
OA Bronze
DA 2025-06-11
ER

PT J
AU Bravard, A
   Bonnard, C
   Durand, A
   Chauvin, MA
   Favier, R
   Vidal, H
   Rieusset, J
AF Bravard, Amelie
   Bonnard, Charlotte
   Durand, Annie
   Chauvin, Marie-Agnes
   Favier, Roland
   Vidal, Hubert
   Rieusset, Jennifer
TI Inhibition of xanthine oxidase reduces hyperglycemia-induced oxidative
   stress and improves mitochondrial alterations in skeletal muscle of
   diabetic mice
SO AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
LA English
DT Article
DE reactive oxygen species; mitochondria; diabetes; oxypurinol
ID FREE-RADICAL PRODUCTION; INSULIN-RESISTANT MICE; NAD(P)H OXIDASE;
   REACTIVE OXYGEN; METABOLIC SYNDROME; NITRIC-OXIDE; IN-VIVO; DYSFUNCTION;
   SUPEROXIDE; EXERCISE
AB Bravard A, Bonnard C, Durand A, Chauvin M, Favier R, Vidal H, Rieusset J. Inhibition of xanthine oxidase reduces hyperglycemia- induced oxidative stress and improves mitochondrial alterations in skeletal muscle of diabetic mice. Am J Physiol Endocrinol Metab 300: E581-E591, 2011. First published January 11, 2011; doi:10.1152/ajpendo.00455.2010.-Reactive oxygen species (ROS) have been widely implicated in the pathogenesis of diabetes and more recently in mitochondrial alterations in skeletal muscle of diabetic mice. However, so far the exact sources of ROS in skeletal muscle have remained elusive. Aiming at better understanding the causes of mitochondrial alterations in diabetic muscle, we designed this study to characterize the sites of ROS production in skeletal muscle of streptozotocin (STZ)-induced diabetic mice. Hyperglycemic STZ mice showed increased markers of systemic and muscular oxidative stress, as evidenced by increased circulating H2O2 and muscle carbonylated protein levels. Interestingly, insulin treatment reduced hyperglycemia and improved systemic and muscular oxidative stress in STZ mice. We demonstrated that increased oxidative stress in muscle of STZ mice is associated with an increase of xanthine oxidase (XO) expression and activity and is mediated by an induction of H2O2 production by both mitochondria and XO. Finally, treatment of STZ mice, as well as high-fat and high-sucrose diet-fed mice, with oxypurinol reduced markers of systemic and muscular oxidative stress and prevented structural and functional mitochondrial alterations, confirming the in vivo relevance of XO in ROS production in diabetic mice. These data indicate that mitochondria and XO are the major sources of hyperglycemia- induced ROS production in skeletal muscle and that the inhibition of XO reduces oxidative stress and improves mitochondrial alterations in diabetic muscle.
C1 [Bravard, Amelie; Bonnard, Charlotte; Durand, Annie; Chauvin, Marie-Agnes; Vidal, Hubert; Rieusset, Jennifer] Univ Lyon, F-69003 Lyon, France.
   [Bravard, Amelie; Bonnard, Charlotte; Durand, Annie; Chauvin, Marie-Agnes; Vidal, Hubert; Rieusset, Jennifer] INSERM, U870, IFR62, F-69008 Lyon, France.
   [Bravard, Amelie; Bonnard, Charlotte; Durand, Annie; Chauvin, Marie-Agnes; Vidal, Hubert; Rieusset, Jennifer] Inst Natl Rech Agron, UMR1235, F-69008 Lyon, France.
   [Bravard, Amelie; Bonnard, Charlotte; Durand, Annie; Chauvin, Marie-Agnes; Vidal, Hubert; Rieusset, Jennifer] Inst Natl Sci Appl, RMND, F-69621 Villeurbanne, France.
   [Bravard, Amelie; Bonnard, Charlotte; Durand, Annie; Chauvin, Marie-Agnes; Vidal, Hubert; Rieusset, Jennifer] Hosp Civils Lyon, F-69008 Lyon, France.
   [Bravard, Amelie; Bonnard, Charlotte; Durand, Annie; Chauvin, Marie-Agnes; Vidal, Hubert; Rieusset, Jennifer] Univ Lyon 1, F-69003 Lyon, France.
   [Favier, Roland] Univ Grenoble 1, Lab Bioenerget Fondamentale & Appl, INSERM, U884, Grenoble, France.
C3 Institut National de la Sante et de la Recherche Medicale (Inserm);
   INRAE; Institut National des Sciences Appliquees de Lyon - INSA Lyon;
   CHU Lyon; Universite Claude Bernard Lyon 1; Institut National de la
   Sante et de la Recherche Medicale (Inserm); Communaute Universite
   Grenoble Alpes; Universite Grenoble Alpes (UGA)
RP Rieusset, J (corresponding author), INRA, UMR INSERM U870, U1235, Fac Med Lyon Sud, 165 Chemin Grand Revoyet,BP12, F-69921 Oullins, France.
EM jennifer.rieusset@univ-lyon1.fr
RI ; Rieusset, Jennifer/F-1595-2018; VIDAL, Hubert/M-6674-2017
OI BERGER, Marie-Agnes/0000-0003-4189-6029; Rieusset,
   Jennifer/0000-0002-1587-2253; VIDAL, Hubert/0000-0002-9467-0317
FU Institut National de la Sante et de la Recherche Medicale; National
   Program on Diabetes Research; Agence Nationale de la Recherche
   [ANR-09-JCJC-0116-01]; Rhones-Alpes Region; Servier Laboratories
   (Suresnes, France)
FX This work was supported by grants from Institut National de la Sante et
   de la Recherche Medicale, the National Program on Diabetes Research, and
   the "Agence Nationale de la Recherche" (grant to J. Rieusset, no.
   ANR-09-JCJC-0116-01). C. Bonnard received a fellowship from Rhones-Alpes
   Region. A. Bravard received a fellowship from Servier Laboratories
   (Suresnes, France).
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NR 46
TC 52
Z9 53
U1 0
U2 17
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0193-1849
EI 1522-1555
J9 AM J PHYSIOL-ENDOC M
JI Am. J. Physiol.-Endocrinol. Metab.
PD MAR
PY 2011
VL 300
IS 3
BP E581
EP E591
DI 10.1152/ajpendo.00455.2010
PG 11
WC Endocrinology & Metabolism; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Physiology
GA 727KA
UT WOS:000287796200017
PM 21224483
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Kayode, OT
   Afolabi, OA
   Ajayi, GO
AF Kayode, Omowumi T.
   Afolabi, Olatayo A.
   Ajayi, Gabriel O.
TI Antioxidant and antilipidemic action of ketogenic diet and tomato powder
   mix in high sugar and fat fed Harwich fruit flies
SO HELIYON
LA English
DT Article
DE Drosophi l a melanogaster; High-fat diet; High-sugar diet; Ketogenic
   diet; Oxidative stress; Tomato
ID METABOLIC-SYNDROME; OXIDATIVE STRESS; LYCOPENE; PATHOGENESIS;
   INFLAMMATION; MECHANISMS
AB Numerous studies have demonstrated the role of oxidative stress in metabolic disorders which presents as a major global problem. The antioxidant properties of the tomato fruit and the ketogenic diet has likewise been established by different authors. This study uses a fruit fly model to examine the synergistic effect of a ketogenic diet and tomato powder mix on biochemical alterations induced by the High-Fat Diet (HFD) and the High-Sugar Diet (HSD). Six groups of male fruit flies consisting of fifty flies per vial were administered Normal Diet (ND), High-Fat Diet (HFD), High Sugar Diet (HSD), Ketogenic Diet (KD), Tomato Powder-mix (TP), and HSD + HFD, for ten days. Further treatment of KD and TP was administered to group six vials to constitute groups seven to nine: HSD + HFD + KD, HSD + HFD + TP, and HSD + HFD + KD + TP for another five days. Biochemical parameters of oxidative stress were analyzed in the fly homogenates using standard procedures. There were significant increases (P < 0.05) in the concentration of malondialdehyde, total cholesterol, LDL-Cholesterol, Triglycerides, atherogenic index, nitric oxide, total weight gained, and a significant decrease (p < 0.05) in levels of catalase and HDLCholesterol in flies treated with HF and HS diets. Further administration of KD and TP to the flies for five days reversed most of the parameters to near control values. The KD diet combination with TP however gave the best ameliorative changes. The dietary model may therefore be effective as adjuvant therapy for the management of metabolic disorders developed and made progressive by oxidative stress and hyperlipidemia.
C1 [Kayode, Omowumi T.; Afolabi, Olatayo A.; Ajayi, Gabriel O.] Mt Top Univ, Coll Basic & Appl Sci, Dept Biochem, Ibafo, Ogun, Nigeria.
RP Kayode, OT (corresponding author), Mt Top Univ, Coll Basic & Appl Sci, Dept Biochem, Ibafo, Ogun, Nigeria.
EM otkayode@mtu.edu.ng
RI KAYODE, OMOWUMI/L-4298-2018
OI Ajayi, Gabriel/0000-0001-7725-7398
CR Arulselvan P, 2016, OXID MED CELL LONGEV, V2016, DOI 10.1155/2016/5276130
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NR 38
TC 0
Z9 0
U1 5
U2 9
PU CELL PRESS
PI CAMBRIDGE
PA 50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA
EI 2405-8440
J9 HELIYON
JI Heliyon
PD OCT
PY 2023
VL 9
IS 10
AR e20411
DI 10.1016/j.heliyon.2023.e20411
EA SEP 2023
PG 9
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA W6HA2
UT WOS:001092604900001
PM 37810861
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Kilic-Toprak, E
   Unver, F
   Ozdemir, Y
   Tekin, E
   Emik, B
   Binbir, HS
   Cort, A
   Bor-Kucukatay, M
AF Kilic-Toprak, Emine
   Unver, Fatma
   Ozdemir, Yasin
   Tekin, Ebru
   Emik, Busra
   Binbir, Hilal Seymanur
   Cort, Aysegul
   Bor-Kucukatay, Melek
TI Examination of hemorheological and exerkine concentrations at four-week
   whole body vibration exercise in obese women: A pilot study
SO BIORHEOLOGY
LA English
DT Article
DE vibration exercise; red blood cell deformability; irisin; visfatin;
   resistin
ID TYPE-2 DIABETES-MELLITUS; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   OXIDATIVE STRESS; VISFATIN; METAANALYSIS; ENDURANCE; STRENGTH;
   OVERWEIGHT; CAPACITY
AB Background Obesity can result in increased visceral adipose tissue, insulin resistance, and impaired fasting glucose. Objective The aim of the study was to investigate the acute and chronic effects of WBVE on erythrocyte deformability, plasma viscosity, total oxidant/antioxidant status (TOS/TAS), oxidative stress index (OSI) and serum exerkine levels in obese women. Methods The study comprised 13 obese women (mean age 41.32 +/- 5.26 years, BMI 34.18 +/- 1.67 kg/m2). Participants performed exercises using a vibration device for 12 sessions. Erythrocyte deformability (ektacytometry), plasma viscosity (rotational viscometry), plasma TOS/TAS, OSI and serum irisin, visfatin and resistin concentrations (ELISA) were evaluated. Blood samples were collected before and after the exercise at the first and fourth weeks. Results Erythrocyte deformability values were increased after single session of WBVE at shear stress of 0.30 and 9.49 Pa and decreased after single session of WBVE at shear stress of 16.87 and 30 Pa (p < 0.05) at the first week. However, after 4 weeks of WBVE, erythrocyte deformability at 0.30 and 0.53 Pa increased; TOS, OSI and plasma viscosity were all decreased (p < 0.05). Serum irisin and resistin levels significantly increased after 4 weeks of WBVE (p < 0.05), whereas visfatin did not show statistically significant changes (p > 0.05). Conclusions Four weeks of WBVE significantly improved the erythrocyte deformability, oxidative stress, plasma viscosity, and serum levels of irisin and resistin in obese women.
C1 [Kilic-Toprak, Emine; Bor-Kucukatay, Melek] Pamukkale Univ, Fac Med, Dept Physiol Kinikli, TR-20070 Denizli, Turkiye.
   [Unver, Fatma] Pamukkale Univ, Phys Therapy & Rehabil Highsch, Denizli, Turkiye.
   [Ozdemir, Yasin] Tercih Common Hlth & Safety Unit, Altieylul, Turkiye.
   [Tekin, Ebru] Balikesir Univ, Bigad Vocat Sch, Dept Therapy & Rehabil, Bigadic, Turkiye.
   [Emik, Busra] Bigad State Hosp, Phys Therapy Unit, Bigadic, Turkiye.
   [Binbir, Hilal Seymanur] Pamukkale Univ, Fac Phys Therapy & Rehabil, Denizli, Turkiye.
   [Cort, Aysegul] Pamukkale Univ, Fac Med, Dept Biochem, Denizli, Turkiye.
C3 Pamukkale University; Pamukkale University; Balikesir University;
   Pamukkale University; Pamukkale University
RP Kilic-Toprak, E (corresponding author), Pamukkale Univ, Fac Med, Dept Physiol Kinikli, TR-20070 Denizli, Turkiye.
EM ektoprak@pau.edu.tr
RI Bilbil, Ebru/Q-1905-2019
FU Pamukkale University Scientific Research Projects Coordination Unit
   [2019HZDP015]
FX This study has been supported by the Pamukkale University Scientific
   Research Projects Coordination Unit (2019HZDP015). The authors declare
   no financial or proprietary interest in any product or company
   associated with any device, instrument or drug mentioned in this
   article. The abstract of this study was presented as oral presentation
   in the 7th Exercise Physiology Symposium Eskisehir, Osmangazi
   University, 25th-26th April 2019. Abstract was printed in the congress
   abstract book, 2019; SB -07(page 42-45). The authors thank Assist. Prof.
   Hande Senol for her help in statistical analyses.
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NR 53
TC 0
Z9 0
U1 0
U2 0
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0006-355X
EI 1878-5034
J9 BIORHEOLOGY
JI Biorheology
PD MAY
PY 2025
VL 60
IS 1-2
BP 38
EP 47
DI 10.1177/0006355X251330982
EA MAR 2025
PG 10
WC Biophysics; Engineering, Biomedical; Hematology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biophysics; Engineering; Hematology
GA 2TP5M
UT WOS:001457559900001
PM 40392016
DA 2025-06-11
ER

PT J
AU Yang, C
   Deng, QC
   Xu, JQ
   Wang, X
   Hu, C
   Tang, H
   Huang, FH
AF Yang, Chen
   Deng, Qianchun
   Xu, Jiqu
   Wang, Xu
   Hu, Chao
   Tang, Hu
   Huang, Fenghong
TI Sinapic acid and resveratrol alleviate oxidative stress with modulation
   of gut microbiota in high-fat diet-fed rats
SO FOOD RESEARCH INTERNATIONAL
LA English
DT Article
DE Gut microbiota; Polyphenols supplementation; Oxidative stress; High-fat
   diet
ID CARDIOVASCULAR-DISEASE; THERAPEUTIC APPROACH; INSULIN-RESISTANCE;
   TRANS-RESVERATROL; INDUCED OBESITY; MOUSE MODEL; IDENTIFICATION;
   INFLAMMATION; POLYPHENOLS; HOMEOSTASIS
AB High-fat diet (HFD) consumption induces oxidative stress and microbial dysbiosis, the latter of which plays a vital role in the development of metabolic syndrome. We hypothesized that sinapic acid and resveratrol treatment might be a potential strategy to ameliorate the redox state and gut microbiota composition imbalance. In this study, rats were randomised into five groups and fed a high-fat diet supplemented with resveratrol (400 mg/ kg), sinapic acid (200 mg/kg) or a combination of both polyphenols. Administration of resveratrol effectively reduced fasting blood glucose levels (p < 0.05) and increased the HDL-c levels (p < 0.05). Reactive oxygen species and malondialdehyde levels were decreased in the colon (p < 0.05), total antioxidant capacity was increased in liver (p < 0.05) by sinapic acid consumption in HFD rats. Moreover, polyphenol supplementation impacted the intestinal microbiome at different taxonomic levels by improving the proportion of butyrate producer Blautia (p < 0.05) and Dorea (p < 0.01) in the Lachaospiraceae family and inhibiting the growth of bacterial species associated with diseases and inflammation such as Bacteroides (p < 0.05) and DesuYovibrionaceaesp (p < 0.01). Spearman correlation analysis showed that some oxidative stress variables were directly correlated with changes in gut microbiota. Our findings demonstrated qualitative differences between the treatments in their abilities to alleviate HFD-induced oxidative stress and modulate the gut microbiota. These findings might be helpful to better understand the effects of bioactive constituents on nutrition for human health.
C1 [Yang, Chen; Deng, Qianchun; Xu, Jiqu; Hu, Chao; Tang, Hu; Huang, Fenghong] Chinese Acad Agr Sci, Minist Agr, Oil Crops Res Inst,Oil Crops & Lipids Proc Techno, Hubei Key Lab Lipid Chem & Nutr,Key Lab Oilseeds, 2 Xudong 2nd Rd, Wuhan 430062, Hubei, Peoples R China.
   [Wang, Xu] Huazhong Agr Univ, 1 Shizishan St, Wuhan 430070, Hubei, Peoples R China.
C3 Chinese Academy of Agricultural Sciences; Oil Crops Research Institute,
   CAAS; Ministry of Agriculture & Rural Affairs; Huazhong Agricultural
   University
RP Tang, H; Huang, FH (corresponding author), Chinese Acad Agr Sci, Oil Crops Res Inst, 2 Xudong 2nd Rd, Wuhan 430062, Hubei, Peoples R China.
EM th725@163.com; huangfh@oilcrops.cn
RI Hu, Chao/G-7633-2012; Yang, Chen/AAM-8727-2020
OI Tang, Hu/0000-0001-5968-3756
FU National Natural Science Foundation of China [:31701560]; Agricultural
   Science and Technology Innovation Project of Chinese Academy of
   Agricultural Sciences [CAAS-ASTIP-2013-OCRI]; Earmarked Fund for China
   Agriculture Research System [CARS-14]; Major Project of Technology
   Innovation Program of Hubei Province [2017ABA144]
FX This work was supported by the National Natural Science Foundation of
   China [grant number:31701560] and the Agricultural Science and
   Technology Innovation Project of Chinese Academy of Agricultural
   Sciences [grant number: CAAS-ASTIP-2013-OCRI], Earmarked Fund for China
   Agriculture Research System [grant number: CARS-14] and Major Project of
   Technology Innovation Program of Hubei Province [grant number:
   2017ABA144].
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NR 67
TC 131
Z9 141
U1 2
U2 145
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0963-9969
EI 1873-7145
J9 FOOD RES INT
JI Food Res. Int.
PD FEB
PY 2019
VL 116
BP 1202
EP 1211
DI 10.1016/j.foodres.2018.10.003
PG 10
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA HL7TC
UT WOS:000458942900132
PM 30716907
DA 2025-06-11
ER

PT J
AU Nogueira, MS
   Kessuane, MC
   Ladd, AABL
   Ladd, FVL
   Cogliati, B
   Castro, IA
AF Nogueira, M. S.
   Kessuane, M. C.
   Lobo Ladd, A. A. B.
   Lobo Ladd, F. V.
   Cogliati, B.
   Castro, I. A.
TI Effect of long-term ingestion of weakly oxidised flaxseed oil on
   biomarkers of oxidative stress in LDL-receptor knockout mice
SO BRITISH JOURNAL OF NUTRITION
LA English
DT Article
DE Flaxseeds; Oxidation; Malondialdehyde; Mice; Atherosclerosis
ID LOW-DENSITY-LIPOPROTEIN; LIPID-PEROXIDATION; APOLIPOPROTEIN-E; METABOLIC
   SYNDROME; POTENTIAL ROLE; ANIMAL-MODELS; MOUSE MODELS; DIET;
   ATHEROSCLEROSIS; LIVER
AB The effect of oxidised fatty acids on atherosclerosis progression is controversial. Thus, our objective was to evaluate the effect of long-term consumption of weakly oxidised PUFA from flaxseed oil on oxidative stress biomarkers of LDL-receptor((-/-)) mice. To test our hypothesis, mice were separated into three groups. The first group received a high-fat diet containing fresh flaxseed oil (CONT-), the second was fed the same diet prepared using heated flaxseed oil (OXID), and the third group received the same diet containing fresh flaxseed oil and had diabetes induced by streptozotocin (CONT+). Oxidative stress, aortic parameters and non-alcoholic fatty liver disease were assessed. After 3 months, plasma lipid profile, glucose levels, body weight, energy intake and dietary intake did not differ among groups. Likewise, oxidative stress, plasma malondialdehyde (MDA), hepatic MDA expressed as nmol/mg portion (ptn) and antioxidant enzymes did not differ among the groups. Hepatic linoleic acid, -linolenic acid, arachidonic acid and EPA acid declined in the OXID and CONT+ groups. Aortic wall thickness, lumen and diameter increased only in the OXID group. OXID and CONT+ groups exhibited higher concentrations of MDA, expressed as mol/mg ptn per %PUFA, when compared with the CONT- group. Our results suggest that ingestion of oxidised flaxseed oil increases hepatic MDA concentration and is potentially pro-atherogenic. In addition, the mean MDA value observed in all groups was similar to those reported in other studies that used xenobiotics as oxidative stress inducers. Thus, the diet applied in this study represents an interesting model for further research involving antioxidants.
C1 [Nogueira, M. S.; Kessuane, M. C.; Castro, I. A.] Univ Sao Paulo, Lab Funct Foods LADAF, Dept Food & Expt Nutr, Fac Pharmaceut Sci, Ave Lineu Prestes 580,B14, BR-05508900 Sao Paulo, Brazil.
   [Lobo Ladd, A. A. B.; Lobo Ladd, F. V.; Cogliati, B.] Univ Sao Paulo, Sch Vet Med & Anim Sci, Ave Prof Dr Orlando Marques de Paiva 87, BR-05508270 Sao Paulo, Brazil.
C3 Universidade de Sao Paulo; Universidade de Sao Paulo
RP Castro, IA (corresponding author), Univ Sao Paulo, Lab Funct Foods LADAF, Dept Food & Expt Nutr, Fac Pharmaceut Sci, Ave Lineu Prestes 580,B14, BR-05508900 Sao Paulo, Brazil.
EM inar@usp.br
RI Ladd, Fernando/I-1826-2012; Ladd, Aliny/C-4130-2012; Castro,
   Inar/C-4923-2012; Cogliati, Bruno/E-9956-2012; Nogueira, Marina
   Sayuri/E-2490-2018
OI Cogliati, Bruno/0000-0002-1388-7240; Nogueira, Marina
   Sayuri/0000-0001-8092-928X
FU Sao Paulo Research Foundation - FAPESP [14/18697-0]; National Council
   for Scientific and Technological Development - CNPq [134621/2013-1];
   Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
   [14/18697-0] Funding Source: FAPESP
FX This research was supported by the Sao Paulo Research Foundation -
   FAPESP (process 14/18697-0) and by the National Council for Scientific
   and Technological Development - CNPq (process 134621/2013-1).
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NR 69
TC 21
Z9 21
U1 0
U2 23
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1145
EI 1475-2662
J9 BRIT J NUTR
JI Br. J. Nutr.
PD JUL 28
PY 2016
VL 116
IS 2
BP 258
EP 269
DI 10.1017/S0007114516001513
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA DQ3XB
UT WOS:000379136100006
PM 27197628
OA Bronze
DA 2025-06-11
ER

PT J
AU Kim, JH
   Park, HY
   Jeon, JD
   Kho, Y
   Kim, SK
   Park, MS
   Hong, YC
AF Kim, Jin Hee
   Park, Hye Yin
   Jeon, Jung Dae
   Kho, Younglim
   Kim, Seung-Kyu
   Park, Min-Seon
   Hong, Yun-Chul
TI The modifying effect of vitamin C on the association between
   perfluorinated compounds and insulin resistance in the Korean elderly: a
   double-blind, randomized, placebo-controlled crossover trial
SO EUROPEAN JOURNAL OF NUTRITION
LA English
DT Article
DE Perfluorinated compounds; Insulin resistance; Oxidative stress; Vitamin
   C supplementation
ID PERFLUOROOCTANOIC ACID PFOA; OXIDATIVE STRESS; METABOLIC SYNDROME;
   LIPID-PEROXIDATION; MUSCLE; CELLS; SERUM; PERFLUOROCHEMICALS;
   SUPPLEMENTATION; POLYMORPHISMS
AB There is limited evidence whether environmental exposure to perfluorinated compounds (PFCs) affects insulin resistance (IR) and whether vitamin C intake protects against the adverse effect of PFCs. This study was carried out to investigate the effect of PFCs on IR through oxidative stress, and the effects of a 4-week consumption of vitamin C supplement compared placebo on development of IR by PFCs.
   For a double-blind, community-based, randomized, placebo-controlled crossover intervention of vitamin C, we assigned 141 elderly subjects to both vitamin C and placebo treatments for 4 weeks. We measured serum levels of PFCs to estimate PFC exposures and urinary levels of malondialdehyde (MDA) and 8-hydroxy-2'-deoxyguanosine (8-OHdG) for oxidative stress. We also measured levels of fasting glucose and insulin and derived the homeostatic model assessment (HOMA) index to assess IR.
   Perfluorooctane sulfonate (PFOS) and perfluorododecanoic acid (PFDoDA) levels were found to be positively associated with HOMA index at the baseline and after placebo treatment. Risks of IR for the top decile of PFOS and PFDoDA exposures were significantly elevated compared with those with lower PFOS and PFDoDA exposures (both, P < 0.0001). However, the effects of PFOS and PFDoDA on HOMA disappeared after vitamin C supplementation (both, P > 0.30). Furthermore, PFOS and PFDoDA levels were also significantly associated with MDA and 8-OHdG levels, and MDA levels were positively associated with HOMA index.
   PFOS and PFDoDA exposures were positively associated with IR and oxidative stress, and vitamin C supplementation protected against the adverse effects of PFOS and PFDoDA on IR.
C1 [Kim, Jin Hee] Seoul Natl Univ, Grad Sch Publ Hlth, Dept Environm Hlth, Seoul, South Korea.
   [Park, Hye Yin; Hong, Yun-Chul] Seoul Natl Univ, Coll Med, Dept Prevent Med, Seoul 110799, South Korea.
   [Jeon, Jung Dae; Kho, Younglim] Eulji Univ, Dept Hlth Environm & Safety, Songnam, South Korea.
   [Kim, Seung-Kyu] Univ Incheon, Coll Nat Sci, Dept Marine Sci, Inchon, South Korea.
   [Park, Min-Seon] Seoul Natl Univ Hosp, Dept Family Med, Seoul 110744, South Korea.
   [Hong, Yun-Chul] Seoul Natl Univ, Med Res Ctr, Inst Environm Med, Seoul, South Korea.
C3 Seoul National University (SNU); Seoul National University (SNU); Eulji
   University; Incheon National University; Seoul National University
   (SNU); Seoul National University Hospital; Seoul National University
   (SNU)
RP Hong, YC (corresponding author), Seoul Natl Univ, Coll Med, Dept Prevent Med, Seoul 110799, South Korea.; Hong, YC (corresponding author), Seoul Natl Univ, Med Res Ctr, Inst Environm Med, Seoul, South Korea.
EM ychong1@snu.ac.kr
RI Hong, Yun-Chul/J-5725-2012; kim, jm/O-5935-2014
OI Kim, Seung-Kyu/0000-0002-1602-3288; KIM, JIN HEE/0000-0003-1204-7079
FU Basic Science Research Program through the National Research Foundation
   of Korea (NRF) - Ministry of Science, ICT and Future Planning, Republic
   of Korea [2013R1A1A3A04004612]
FX This study was supported by the Basic Science Research Program through
   the National Research Foundation of Korea (NRF) funded by the Ministry
   of Science, ICT and Future Planning (2013R1A1A3A04004612), Republic of
   Korea. J. H. Kim drew the conception, researched data, and wrote the
   manuscript. Y. C. Hong discussed, reviewed, and edited manuscript. H. Y.
   Park performed the health examination and is the guarantor of this work,
   and as such, had full access to all the data in the study and takes
   responsibility for the integrity of the data and the accuracy of the
   data analysis. J. D. Jeon, Y. Kho, and S. K. Kim contributed
   reagents/materials/ analysis tools. M. S. Park performed the health
   examination and reviewed the manuscript.
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TC 27
Z9 29
U1 2
U2 32
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1436-6207
EI 1436-6215
J9 EUR J NUTR
JI Eur. J. Nutr.
PD APR
PY 2016
VL 55
IS 3
BP 1011
EP 1020
DI 10.1007/s00394-015-0915-0
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA DJ3NS
UT WOS:000374112900012
PM 25939797
DA 2025-06-11
ER

PT J
AU Saneei, P
   Hashemipour, M
   Kelishadi, R
   Esmaillzadeh, A
AF Saneei, Parvane
   Hashemipour, Mahin
   Kelishadi, Roya
   Esmaillzadeh, Ahmad
TI The Dietary Approaches to Stop Hypertension (DASH) Diet Affects
   Inflammation in Childhood Metabolic Syndrome: A Randomized Cross-Over
   Clinical Trial
SO ANNALS OF NUTRITION AND METABOLISM
LA English
DT Article
DE Dietary Approaches to Stop Hypertension diet; Inflammation; Childhood
   metabolic syndrome
ID C-REACTIVE PROTEIN; SYSTEMIC INFLAMMATION; OXIDATIVE STRESS; IRANIAN
   WOMEN; LIFE-STYLE; VITAMIN-C; ADOLESCENTS; MARKERS; CONSUMPTION;
   CHILDREN
AB Background: The effects of the DASH (Dietary Approaches to Stop Hypertension) diet on inflammation in childhood metabolic syndrome (MetS) have still to be identified. Objective: To examine the effects of the DASH diet on markers of systemic inflammation in adolescents with MetS. Methods: In this randomized, cross-over clinical trial, 60 postpubescent girls with MetS were randomly assigned to receive either the DASH diet menu cycles or usual dietary advice (UDA) for 6 weeks. After a 4-week washout period, participants were crossed over to the alternate arm. The DASH diet was designed to maintain the current body weight. This diet contained high amounts of fruit, vegetables and low-fat dairy products and was low in saturated fats and cholesterol. UDA consisted of general oral advice and written information about healthy food choices based on the Healthy Eating Plate. Compliance to the DASH diet was assessed through quantification of plasma vitamin C levels. Fasting venous blood samples were taken 4 times from each participant: at baseline and at the end of each study arm. Circulating levels of biomarkers of systemic inflammation were quantified according to standard protocols. Results: Mean (SD) age and weight of participants was 14.2 years (1.7) and 69 kg (14.5), respectively. Serum vitamin C levels tended to increase during the DASH phase compared with the UDA phase (16.8 +/- 12.9 vs. -13.8 +/- 9.7 ng/dl, respectively, p = 0.06) indicating a relatively good compliance to the DASH diet. Adherence to the DASH diet, compared to the UDA, had a significant effect on serum high-sensitivity C-reactive protein levels (p = 0.002). This effect remained significant even after adjustment for weight changes and after further controlling for changes in lipid profiles. We did not observe any significant effect of intervention on levels of serum tumor necrosis factor-alpha, interleukin (IL)-2, IL-6 and adiponectin, in either the crude or adjusted models. There were no significant group*time interactions for any dependent variable, except for IL-6; this was close to the significant level. Conclusion: In summary, consumption of the DASH eating pattern for 6 weeks may reduce circulating levels of hs-CRP among adolescents with MetS. Other inflammatory markers were not affected by the DASH diet. (C) 2014 S. Karger AG, Basel
C1 [Saneei, Parvane; Esmaillzadeh, Ahmad] Isfahan Univ Med Sci, Food Secur Res Ctr, Esfahan, Iran.
   [Saneei, Parvane; Esmaillzadeh, Ahmad] Isfahan Univ Med Sci, Sch Nutr & Food Sci, Dept Community Nutr, Esfahan, Iran.
   [Hashemipour, Mahin; Kelishadi, Roya] Isfahan Univ Med Sci, Child Growth & Dev Res Ctr, Dept Pediat, Dept Endocrinol & Pediat, Esfahan, Iran.
   [Hashemipour, Mahin; Kelishadi, Roya] Isfahan Univ Med Sci, Child Growth & Dev Res Ctr, Dept Pediat, Esfahan, Iran.
   [Hashemipour, Mahin; Kelishadi, Roya] Isfahan Univ Med Sci, Fac Med, Dept Pediat, Esfahan, Iran.
C3 Isfahan University of Medical Sciences; Isfahan University of Medical
   Sciences; Isfahan University of Medical Sciences; Isfahan University of
   Medical Sciences; Isfahan University of Medical Sciences
RP Esmaillzadeh, A (corresponding author), Isfahan Univ Med Sci, Sch Nutr & Food Sci, Dept Community Nutr Dean, POB 81745, Esfahan, Iran.
EM esmaillzadeh@hlth.mui.ac.ir
RI Saneei, Parvane/T-5434-2019; Mehrkash, Mehryar/D-5317-2018;
   Esmaillzadeh, Ahmad/N-5704-2014; Kelishadi, Roya/E-6154-2012
OI Mehrkash, Mehryar/0000-0001-6418-5743; Esmaillzadeh,
   Ahmad/0000-0002-8735-6047; Saneei, Parvane/0000-0002-4605-7833;
   Kelishadi, Roya/0000-0001-7455-1495
FU Research Council of Food Security Research Center, Isfahan University of
   Medical Sciences as well as the Research Council of Iran National
   Talents Foundation
FX The authors would like to thank the Research Council of Food Security
   Research Center, Isfahan University of Medical Sciences as well as the
   Research Council of Iran National Talents Foundation for their financial
   support for this study.
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NR 34
TC 66
Z9 84
U1 0
U2 29
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0250-6807
EI 1421-9697
J9 ANN NUTR METAB
JI Ann. Nutr. Metab.
PY 2014
VL 64
IS 1
BP 20
EP 27
DI 10.1159/000358341
PG 8
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA AJ9AU
UT WOS:000338000000004
PM 24686130
DA 2025-06-11
ER

PT J
AU De la Fuente-Muñoz, M
   De la Fuente-Fernández, M
   Román-Carmena, M
   Amor, S
   Iglesias de la Cruz, MC
   García-Laínez, G
   Llopis, S
   Martorell, P
   Verdú, D
   Serna, E
   García-Villalón, AL
   Guilera, SI
   Inarejos-García, AM
   Granado, M
AF De la Fuente-Munoz, Mario
   De la Fuente-Fernandez, Maria
   Roman-Carmena, Marta
   Amor, Sara
   Iglesias de la Cruz, Maria C.
   Garcia-Lainez, Guillermo
   Llopis, Silvia
   Martorell, Patricia
   Verdu, David
   Serna, Eva
   Garcia-Villalon, Angel L.
   Guilera, Sonia I.
   Inarejos-Garcia, Antonio M.
   Granado, Miriam
TI Supplementation with a New Standardized Extract of Green and Black Tea
   Exerts Antiadipogenic Effects and Prevents Insulin Resistance in Mice
   with Metabolic Syndrome
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE obesity; metabolic syndrome; insulin resistance; green tea; black tea;
   extract; antioxidant
ID ARYL-HYDROCARBON RECEPTOR; TYPE-2 DIABETES-MELLITUS; FATTY
   LIVER-DISEASE; BODY-WEIGHT; LIPID-ACCUMULATION; GLUCOSE-TOLERANCE;
   OXIDATIVE STRESS; GLYCEMIC CONTROL; GENE-EXPRESSION; IN-VITRO
AB Insulin resistance is one of the main characteristics of metabolic syndrome (MetS) and the main cause of the development of type II diabetes. The high prevalence of this syndrome in recent decades has made it necessary to search for preventive and therapeutic agents, ideally of natural origin, with fewer side effects than conventional pharmacological treatments. Tea is widely known for its medicinal properties, including beneficial effects on weight management and insulin resistance. The aim of this study was to analyze whether a standardized extract of green and black tea (ADM((R)) Complex Tea Extract (CTE)) prevents the development of insulin resistance in mice with MetS. For this purpose, C57BL6/J mice were fed for 20 weeks with a standard diet (Chow), a diet with 56% kcal from fat and sugar (HFHS) or an HFHS diet supplemented with 1.6% CTE. CTE supplementation reduced body weight gain, adiposity and circulating leptin levels. Likewise, CTE also exerted lipolytic and antiadipogenic effects in 3T3-L1 adipocyte cultures and in the C. elegans model. Regarding insulin resistance, CTE supplementation significantly increased plasma adiponectin concentrations and reduced the circulating levels of insulin and the HOMA-IR. Incubation of liver, gastrocnemius muscle and retroperitoneal adipose tissue explants with insulin increased the pAkt/Akt ratio in mice fed with Chow and HFHS + CTE but not in those fed only with HFHS. The greater activation of the PI3K/Akt pathway in response to insulin in mice supplemented with CTE was associated with a decrease in the expression of the proinflammatory markers Mcp-1, IL-6, IL-1 beta or Tnf-alpha and with an overexpression of the antioxidant enzymes Sod-1, Gpx-3, Ho-1 and Gsr in these tissues. Moreover, in skeletal muscle, mice treated with CTE showed increased mRNA levels of the aryl hydrocarbon receptor (Ahr), Arnt and Nrf2, suggesting that the CTE's insulin-sensitizing effects could be the result of the activation of this pathway. In conclusion, supplementation with the standardized extract of green and black tea CTE reduces body weight gain, exerts lipolytic and antiadipogenic effects and reduces insulin resistance in mice with MetS through its anti-inflammatory and antioxidant effects.
C1 [De la Fuente-Munoz, Mario; De la Fuente-Fernandez, Maria; Roman-Carmena, Marta; Amor, Sara; Iglesias de la Cruz, Maria C.; Garcia-Villalon, Angel L.; Granado, Miriam] Univ Autonoma Madrid, Fac Med, Dept Fisiol, Madrid 28029, Spain.
   [Garcia-Lainez, Guillermo; Llopis, Silvia; Martorell, Patricia] Univ Valencia, Nutr Archer Daniels Midland ADM Hlth & Wellness, Biopolis S L Parc Cientif, Paterna 46980, Spain.
   [Verdu, David; Serna, Eva] Univ Valencia, Fac Med, Dept Fisiol, Valencia 46010, Spain.
   [Guilera, Sonia I.; Inarejos-Garcia, Antonio M.] ADM Valencia, R&D Dept Funct Extracts, Carcaixent 46740, Spain.
   [Granado, Miriam] Inst Salud Carlos III, Ctr Invest Biomed Red Fisiopatol Obes & Nutr, Madrid 28029, Spain.
C3 Autonomous University of Madrid; University of Valencia; University of
   Valencia; Instituto de Salud Carlos III; CIBER - Centro de Investigacion
   Biomedica en Red; CIBEROBN
RP Granado, M (corresponding author), Univ Autonoma Madrid, Fac Med, Dept Fisiol, Madrid 28029, Spain.; Granado, M (corresponding author), Inst Salud Carlos III, Ctr Invest Biomed Red Fisiopatol Obes & Nutr, Madrid 28029, Spain.
EM miriam.granado@uam.es
RI Garcia-Lainez, Guillermo/AAO-1837-2021; Garcia-Villalon,
   Angel/AAA-3067-2019; Martorell, Patricia/ABC-8717-2021; serna,
   eva/Z-1433-2019; Iglesias-de la Cruz, Maria Carmen/A-6630-2010; Granado,
   Miriam/B-8978-2017
OI SERNA GARCIA, EVA/0000-0002-2968-3349; Iglesias-de la Cruz, Maria
   Carmen/0000-0003-0596-1284; Roman Carmena, Marta/0000-0001-9104-2959;
   Granado, Miriam/0000-0001-9178-8822; INAREJOS GARCIA, ANTONIO
   MANUEL/0000-0002-4869-6188; Martorell, Patricia/0000-0001-5689-8399
FU company ADM Wild; Universidad Autonoma de Madrid through the 2nd Call of
   "Programa de Fomento de la Transferencia del Conocimiento UAM";
   Community of Madrid [PEJ-2018-AI/SAL-11315, PEJ-2020-AI/BMD-19155]
FX This work has been funded by the company ADM Wild and by the Universidad
   Autonoma de Madrid through the 2nd Call of "Programa de Fomento de la
   Transferencia del Conocimiento UAM". The Community of Madrid funded the
   contract of Maria de la Fuente-Fernandez (PEJ-2018-AI/SAL-11315) and
   Mario de la Fuente Munoz (PEJ-2020-AI/BMD-19155) through the Youth
   Employment Program.
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   Zhou F, 2022, FOOD RES INT, V161, DOI 10.1016/j.foodres.2022.111788
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NR 80
TC 7
Z9 7
U1 3
U2 25
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD MAY 10
PY 2023
VL 24
IS 10
AR 8521
DI 10.3390/ijms24108521
PG 23
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA H7ZJ3
UT WOS:000998095900001
PM 37239868
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Cocate, PG
   Natali, AJ
   Alfenas, RCG
   de Oliveira, A
   dos Santos, EC
   Hermsdorff, HHM
AF Cocate, P. G.
   Natali, A. J.
   Alfenas, R. C. G.
   de Oliveira, A.
   dos Santos, E. C.
   Hermsdorff, H. H. M.
TI Carotenoid consumption is related to lower lipid oxidation and DNA
   damage in middle-aged men
SO BRITISH JOURNAL OF NUTRITION
LA English
DT Article
DE Food habits; Carotenoids; Lipids; Oxidative stress
ID CORONARY-ARTERY-DISEASE; BETA-CAROTENE; YOUNG-ADULTS;
   DENSITY-LIPOPROTEIN; DIETARY CAROTENOIDS; METABOLIC SYNDROME; SERUM
   CAROTENOIDS; RISK DEVELOPMENT; TOMATO PRODUCTS; STRESS MARKERS
AB The present cross-sectional study assessed the potential relationships of carotenoid intake with lipid and oxidative stress markers in middle-aged men. A total of 296 apparently healthy middle-aged men (mean age 50.5 (SD 5.0) years, BMI 25.8 (SD 3.5) kg/m(2)) were recruited to participate in the study. Dietary intake, anthropometry, blood pressure, lifestyle features, blood and urine biomarkers were assessed using validated procedures. The lipid markers included NEFA, Castelli index, and TAG:HDL ratio; oxidative stress markers included urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG), 8-iso-PGF2 alpha and plasma oxidised-LDL (ox-LDL). We observed a significant inverse association (P<0.05) between NEFA concentrations and consumption of lutein plus zeaxanthin, beta-carotene, alpha-carotene and total carotenoid, while Castelli index was negatively associated with daily intake of lycopene, beta-carotene and total carotenoids. Regarding oxidative stress biomarkers, urinary 8-OHdG and ox-LDL concentrations were also inversely associated (P<0.05) with consumption of lycopene, lutein plus zeaxanthin, beta-carotene, alpha-carotene and total carotenoids, regardless of confounding variables. Moreover, there was a negative association of urinary 8-iso-PGF2 alpha concentration with dietary lutein plus zeaxanthin (beta -0.135, 95% CI -0.268, -0.001), beta-carotene (beta -0.156, 95% CI -0.277, -0.034) and with the sum of all carotenoids (beta -0.189, 95% CI -0.333, -0.046). In conclusion, total daily carotenoid intake based on five investigated carotenoid types (beta-cryptoxanthin, lycopene, lutein plus zeaxanthin, beta-carotene and alpha-carotene) was inversely associated with relevant lipid and oxidative stress markers in middle-aged men, with emphasis on beta-carotene that was negatively associated with five of the six lipid and oxidative stress markers evaluated in the present study.
C1 [Cocate, P. G.; Alfenas, R. C. G.; Hermsdorff, H. H. M.] Univ Fed Vicosa, Dept Nutr & Hlth, BR-36571900 Vicosa, MG, Brazil.
   [Natali, A. J.] Univ Fed Vicosa, Dept Phys Educ, BR-36571900 Vicosa, MG, Brazil.
   [de Oliveira, A.] Univ Fed Sao Joao del Rei, Dept Phys Educ Sci & Hlth, Sao Joao Del Rei, MG, Brazil.
   [dos Santos, E. C.] Univ Fed Vicosa, Dept Gen Biol, BR-36571900 Vicosa, MG, Brazil.
C3 Universidade Federal de Vicosa; Universidade Federal de Vicosa;
   Universidade Federal de Sao Joao del-Rei; Universidade Federal de Vicosa
RP Hermsdorff, HHM (corresponding author), Univ Fed Vicosa, Dept Nutr & Hlth, Ave PH Rolfs, BR-36571900 Vicosa, MG, Brazil.
EM helenhermana@ufv.br
RI de Oliveira, Alessandro/ABF-5840-2021; Guedes Cocate, Paula/P-7621-2018;
   santos, Eliziaria/M-3107-2017; Hermsdorff, Helen Hermana
   Miranda/H-4525-2015; Natali, Antonio Jose/C-1555-2013
OI Guedes Cocate, Paula/0000-0003-1208-6481; Alfenas,
   Rita/0000-0003-2290-1611; santos, Eliziaria/0000-0003-0825-5836; de
   Oliveira, Alessandro/0000-0003-3510-7070; Santos, Eliziaria
   Cardoso/0000-0002-3030-7746; Hermsdorff, Helen Hermana
   Miranda/0000-0002-4441-6572; Natali, Antonio Jose/0000-0002-4927-4024
FU Foundation for Research Support of the State of Minas Gerais
   [CDS-APQ-02189-10, CDS-APQ-02535-13]
FX This work was supported by the Foundation for Research Support of the
   State of Minas Gerais (grant number CDS-APQ-02189-10 and
   CDS-APQ-02535-13). A. J. N., R. C. G. A., and H. H. M. H. are CNPq
   fellows.
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NR 53
TC 43
Z9 47
U1 0
U2 10
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1145
EI 1475-2662
J9 BRIT J NUTR
JI Br. J. Nutr.
PD JUL 28
PY 2015
VL 114
IS 2
BP 257
EP 264
DI 10.1017/S0007114515001622
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA CO3TZ
UT WOS:000359084200011
PM 26079483
OA Bronze
DA 2025-06-11
ER

PT J
AU López-Domènech, S
   Martínez-Herrera, M
   Abad-Jiménez, Z
   Morillas, C
   Escribano-López, I
   Díaz-Morales, N
   Bañuls, C
   Víctor, VM
   Rocha, M
AF Lopez-Domenech, Sandra
   Martinez-Herrera, Mayte
   Abad-Jimenez, Zaida
   Morillas, Carlos
   Escribano-Lopez, Irene
   Diaz-Morales, Noelia
   Banuls, Celia
   Victor, Victor M.
   Rocha, Milagros
TI Dietary weight loss intervention improves subclinical atherosclerosis
   and oxidative stress markers in leukocytes of obese humans
SO INTERNATIONAL JOURNAL OF OBESITY
LA English
DT Article
ID LEUKOCYTE/ENDOTHELIAL CELL-INTERACTIONS; SERUM MYELOPEROXIDASE LEVELS;
   LOW-DENSITY-LIPOPROTEIN; OVARY-SYNDROME PATIENTS; METABOLIC SYNDROME;
   MONONUCLEAR-CELLS; ENDOTHELIAL-CELLS; TNF-ALPHA; INDIVIDUALS;
   DYSFUNCTION
AB Background The relationship between caloric restriction-mediated weight loss and the generation of ROS and its effects on atherosclerotic markers in obesity is not fully understood. Therefore, we set out to investigate whether dietary weight loss intervention improves markers of oxidative stress in leukocytes and subclinical parameters of atherosclerosis.
   Subjects and Methods This was an interventional study of 59 obese subjects (BMI > 35 kg/m(2)) who underwent 6 months of dietary therapy, including a 6-week very-low-calorie diet (VLCD) followed by an 18-week low-calorie diet (LCD). We determined clinical parameters, inflammatory markers-hsCRP, TNF alpha and NF kappa B -, oxidative stress parameters-total superoxide, glutathione, catalase activity and protein carbonyl groups-, soluble cellular adhesion molecules-sICAM, sPselectin, sPSGL-1 -, myeloperoxidase (MPO), leukocyte-endothelium cell interactions-rolling flux, velocity and adhesion -and LDL subfractions, before and after the dietary intervention.
   Results After losing weight, an improvement was observed in the patients' anthropometric, blood pressure and metabolic parameters, and was associated with reduced inflammatory response (hsCRP, TNF alpha and NF kappa B). Oxidative stress parameters improved, since superoxide production and protein carbonyl content were reduced and antioxidant systems were enhanced. In addition, a significant reduction of subclinical markers of atherosclerosis-small and dense LDL particles, MPO, sPselectin and leukocyte adhesion-and an increase in soluble PSGL-1 were reported.
   Conclusions Our findings reveal that the improvement of subclinical atherosclerotic markers after dietary weight loss intervention is associated with a reduction of oxidative stress in leukocytes and inflammatory pathways, suggesting that these are the underlying mechanisms responsible for the reduced risk of cardiovascular disease in obese subjects after losing weight.
C1 [Lopez-Domenech, Sandra; Abad-Jimenez, Zaida; Morillas, Carlos; Escribano-Lopez, Irene; Diaz-Morales, Noelia; Banuls, Celia; Victor, Victor M.; Rocha, Milagros] Univ Hosp Doctor Peset FISABIO, Serv Endocrinol & Nutr, Av Gaspar Aguilar 90, Valencia 46017, Spain.
   [Martinez-Herrera, Mayte] Univ Hosp Doctor Peset FISABIO, Serv Stomatol, Av Gaspar Aguilar 90, Valencia 46017, Spain.
   [Victor, Victor M.; Rocha, Milagros] Univ Valencia, CIBER CB06 04 0071 Res Grp, CIBER Hepat & Digest Dis, Av Blasco Ibanez 13, Valencia 46010, Spain.
   [Victor, Victor M.] Univ Valencia, Dept Physiol, Av Blasco Ibanez 13, Valencia 46010, Spain.
C3 CIBER - Centro de Investigacion Biomedica en Red; CIBEREHD; University
   of Valencia; University of Valencia
RP Víctor, VM; Rocha, M (corresponding author), Univ Hosp Doctor Peset FISABIO, Serv Endocrinol & Nutr, Av Gaspar Aguilar 90, Valencia 46017, Spain.; Víctor, VM; Rocha, M (corresponding author), Univ Valencia, CIBER CB06 04 0071 Res Grp, CIBER Hepat & Digest Dis, Av Blasco Ibanez 13, Valencia 46010, Spain.; Víctor, VM (corresponding author), Univ Valencia, Dept Physiol, Av Blasco Ibanez 13, Valencia 46010, Spain.
EM victor.victor@uv.es; milagros.rocha@uv.es
RI VICTOR, VICTOR/I-3270-2015; Morillas, Carlos/ABF-3504-2020; Domènech,
   Sandra/AAA-9732-2020; Diaz-Morales, Noelia/H-1978-2015; Rocha,
   Milagros/I-4987-2015; Banuls, Celia/H-7359-2017
OI Diaz-Morales, Noelia/0000-0003-1657-2700; Rocha,
   Milagros/0000-0003-2923-6546; Banuls, Celia/0000-0001-8077-7642;
   Morillas, Carlos/0000-0002-3745-4423; Lopez Domenech,
   Sandra/0000-0003-2067-9308
FU Carlos III Health Institute [PI16/00301, PI16/01083, FI14/00350,
   FI14/00125, FI17/00144, CPII16/0037]; European Regional Development Fund
   (ERDF "A way to build Europe"); FISABIO [UGP-15-220, UGP-15-144];
   Menarini S.A.; Valencian Regional Ministry of Education [ACIF/2015/226]
FX We acknowledge the editorial assistance of Brian Normanly (CIBERehd).
   This study was supported by grant PI16/00301 and PI16/01083 from Carlos
   III Health Institute and has been co-funded by the European Regional
   Development Fund (ERDF "A way to build Europe") and UGP-15-220 from
   FISABIO. Unrestricted grant from Menarini S.A. MM-H is a predoctoral
   fellowship from Valencian Regional Ministry of Education
   (ACIF/2015/226), SL-D, ND-M and ZA-J are recipients of a predoctoral
   fellowship and from Carlos III Health Institute (FI14/00350, FI14/00125
   and FI17/00144, respectively). IE-L has a predoctoral fellowship from
   FISABIO (UGP-15-144). MR is recipient of Miguel Servet (CPII16/0037)
   contract from Carlos III Health Institute.
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NR 40
TC 30
Z9 30
U1 0
U2 9
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0307-0565
EI 1476-5497
J9 INT J OBESITY
JI Int. J. Obes.
PD NOV
PY 2019
VL 43
IS 11
BP 2200
EP 2209
DI 10.1038/s41366-018-0309-5
PG 10
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA JK6RC
UT WOS:000494968500008
PM 30622308
DA 2025-06-11
ER

PT J
AU Agba, OB
   Lausser, L
   Huse, K
   Bergmeier, C
   Jahn, N
   Groth, M
   Bens, M
   Sahm, A
   Gall, M
   Witte, OW
   Kestler, HA
   Schwab, M
   Platzer, M
AF Agba, Ogechukwu Brenda
   Lausser, Ludwig
   Huse, Klaus
   Bergmeier, Christoph
   Jahn, Niels
   Groth, Marco
   Bens, Martin
   Sahm, Arne
   Gall, Maria
   Witte, Otto W.
   Kestler, Hans A.
   Schwab, Matthias
   Platzer, Matthias
TI Tissue-, sex-, and age-specific DNA methylation of rat glucocorticoid
   receptor gene promoter and insulin-like growth factor 2 imprinting
   control region
SO PHYSIOLOGICAL GENOMICS
LA English
DT Article
DE epigenetics; DNA methylation; aging
ID MESSENGER-RNA; CPG ISLANDS; EXPRESSION; STRESS; MOUSE; H19;
   IDENTIFICATION; METAANALYSIS; MECHANISMS; METHYLOMES
AB Tissue-, sex-, and age-specific epigenetic modifications such as DNA methylation are largely unknown. Changes in DNA methylation of the glucocorticoid receptor gene (NR3C1) and imprinting control region (ICR) of IGF2 and H19 genes during the lifespan are particularly interesting since these genes are susceptible to epigenetic modifications by prenatal stress or malnutrition. They are important regulators of development and aging. Methylation changes of NR3C1 affect glucocorticoid receptor expression, which is associated with stress sensitivity and stress-related diseases predominantly occurring during aging. Methylation changes of IGF2/H19 affect growth trajectory and nutrient use with risk of metabolic syndrome. Using a locus-specific approach, we characterized DNA methylation patterns of different Nr3c1 promoters and Igf2/H19 ICR in seven tissues of rats at 3, 9, and 24 mo of age. We found a complex pattern of locus-, tissue-, sex-, and age-specific DNA methylation. Tissue-specific methylation was most prominent at the shores of the Nr3c1 CpG island (CGI). Sex-specific differences in methylation peaked at 9 mo. During aging, Nr3c1 predominantly displayed hypomethylation mainly in females and at shores, whereas hypermethylation occurred within the CGI. Igf2/H19 ICR exhibited age-related hypomethylation occurring mainly in males. Methylation patterns of Nr3c1 in the skin correlated with those in the cortex, hippocampus, and hypothalamus. Skin may serve as proxy for methylation changes in central parts of the hypothalamic-pituitary-adrenal axis and hence for vulnerability to stress-and age-associated diseases. Thus, we provide in-depth insight into the complex DNA methylation changes of rat Nr3c1 and Igf2/H19 during aging that are tissue and sex specific.
C1 [Agba, Ogechukwu Brenda; Huse, Klaus; Jahn, Niels; Groth, Marco; Bens, Martin; Sahm, Arne; Platzer, Matthias] Fritz Lipmann Inst, Leibniz Inst Aging, Genome Anal, Jena, Germany.
   [Lausser, Ludwig; Kestler, Hans A.] Leibniz Inst Aging, Fritz Lipmann Inst, Syst Biol Aging, Jena, Germany.
   [Lausser, Ludwig; Kestler, Hans A.] Ulm Univ, Inst Med Syst Biol, Ulm, Germany.
   [Bergmeier, Christoph; Jahn, Niels; Gall, Maria; Witte, Otto W.; Schwab, Matthias] Jena Univ Hosp, Hans Berger Dept Neurol, Jena, Germany.
C3 Leibniz Association; Leibniz Institut fur Alternsforschung -
   Fritz-Lipmann-Institut (FLI); Leibniz Association; Leibniz Institut fur
   Alternsforschung - Fritz-Lipmann-Institut (FLI); Ulm University;
   Friedrich Schiller University of Jena
RP Platzer, M (corresponding author), Leibniz Inst Aging, Fritz Lipmann Inst, Beutenbergstr 11, D-07745 Jena, Germany.
EM Matthias.Platzer@leibniz-fli.de
RI Sahm, Arne/AAG-3842-2019; Kestler, Hans A./D-5799-2012; ,
   Otto/P-4127-2018
OI Kestler, Hans A./0000-0002-4759-5254; , Otto/0000-0003-2101-4105; Bens,
   Martin/0000-0001-7940-6668; Sahm, Arne/0000-0002-7330-1790
FU European Community's Seventh Framework Programme
   [FP7-HEALTH-2012-279281]
FX The research was financially supported by the European Community's
   Seventh Framework Programme (FP7-HEALTH-2012-279281).
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NR 67
TC 15
Z9 16
U1 1
U2 13
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 1094-8341
EI 1531-2267
J9 PHYSIOL GENOMICS
JI Physiol. Genomics
PD NOV
PY 2017
VL 49
IS 11
BP 690
EP 702
DI 10.1152/physiolgenomics.00009.2017
PG 13
WC Cell Biology; Genetics & Heredity; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Genetics & Heredity; Physiology
GA FN6PG
UT WOS:000416137400008
PM 28916632
DA 2025-06-11
ER

PT J
AU Jia, Y
   Yee, JK
   Wang, C
   Nikolaenko, L
   Diaz-Arjonilla, M
   Cohen, JN
   French, SW
   Liu, PY
   Lue, YH
   Lee, WNP
   Swerdloff, RS
AF Jia, Yue
   Yee, Jennifer K.
   Wang, Christina
   Nikolaenko, Liana
   Diaz-Arjonilla, Maruja
   Cohen, Joshua N.
   French, Samuel W.
   Liu, Peter Y.
   Lue, YanHe
   Lee, Wai-Nang P.
   Swerdloff, Ronald S.
TI Testosterone protects high-fat/low-carbohydrate diet-induced
   nonalcoholic fatty liver disease in castrated male rats mainly via
   modulating endoplasmic reticulum stress
SO AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
LA English
DT Article
DE ApoB100; ER stress; hepatic steatosis; lipid droplet; lipogenesis;
   testosterone deficiency
ID LACKING ANDROGEN RECEPTOR; HEPATIC STEATOSIS; INSULIN-RESISTANCE;
   METABOLIC SYNDROME; MITOCHONDRIAL ABNORMALITIES; APOLIPOPROTEIN-B;
   NATURAL-HISTORY; GENE-EXPRESSION; ADIPOSE-TISSUE; DEFICIENT MICE
AB We previously showed that testosterone (T) deficiency enhanced high-fat/low-carbohydrate diet (HFD)-induced hepatic steatosis in rats independent of insulin resistance and that T replacement reduced hepatic macrovesicular fat accumulation and inflammation. The present report explores the mechanism of Ts protective effects on HFD-induccd steatohepatitis. Adult male rats were randomized into four treatment groups for 15 wk: intact rats on regular chow diet or HFD, and castrated rats on HFD with or without T replacement. Fatty acid beta-oxidation and de novo synthesis were not changed by castration and T replacement, but expression of lipid export proteins ApoB100 and microsomal triglyceride transfer protein (MTP) was suppressed by HFD in both intact and castrated rats but restored by T replacement. Macrovesicular lipid droplet-related proteins perilipin 1 and fat-specific protein 27 were increased by HFD in castrated rats and suppressed by T replacement. Higher activation/ expression of ER stress proteins (PERK, IRE-l alpha,JNK, NF-kB, and CHOP) was demonstrated in castrated rats fed HFD compared with intact animals, and T replacement suppressed these changes. We conclude that 1) HFD leads to ApoBlOO/MTP suppression reducing export of lipids; 2) castration promotes progression to steatohepatitis through activation of the ER stress pathway and enhancement of macrovesicular droplet protein expression; and 3) testosterone suppresses ER stress, inhibits the formation of macrovesicular lipid droplets, promotes lipid export, and ameliorates steatohepatitis induced by HFD and castration.
C1 [Jia, Yue; Wang, Christina; Nikolaenko, Liana; Diaz-Arjonilla, Maruja; Liu, Peter Y.; Lue, YanHe; Swerdloff, Ronald S.] Harbor Univ Calif Los Angeles UCLA Med Ctr, Dept Med, Div Endocrinol, Torrance, CA USA.
   [Yee, Jennifer K.; Cohen, Joshua N.; Lee, Wai-Nang P.] Harbor UCLA Med Ctr, Dept Pediat, Torrance, CA 90509 USA.
   [Yee, Jennifer K.; Cohen, Joshua N.; Lee, Wai-Nang P.] Harbor UCLA Med Ctr, Dept Pediat, Endocrinol, Torrance, CA 90509 USA.
   [French, Samuel W.; Swerdloff, Ronald S.] Harbor UCLA Med Ctr, Dept Pathol, Torrance, CA 90509 USA.
   [Jia, Yue; Yee, Jennifer K.; Wang, Christina; Nikolaenko, Liana; Diaz-Arjonilla, Maruja; Cohen, Joshua N.; French, Samuel W.; Liu, Peter Y.; Lue, YanHe; Lee, Wai-Nang P.; Swerdloff, Ronald S.] Los Angeles Biomed Res Inst, Torrance, CA USA.
C3 University of California System; University of California Los Angeles;
   University of California System; University of California Los Angeles;
   University of California Los Angeles Medical Center; University of
   California System; University of California Los Angeles; University of
   California Los Angeles Medical Center; University of California System;
   University of California Los Angeles; University of California Los
   Angeles Medical Center; Lundquist Institute
RP Swerdloff, RS (corresponding author), Univ Calif Los Angeles, David Geffen Sch Med, Harbor UCLA Med Ctr, Los Angeles Biomed Res Inst,Div Endocrinol, 1124 West Carson St, Torrance, CA 90502 USA.
EM swerdloff@labiomed.org
RI LUE, YANHE/AAN-4861-2021
OI Yee, Jennifer K./0000-0002-2423-8318; LUE, YANHE/0000-0003-0458-7841
FU General Clinical Research Center at Los Angeles Biomedical Research
   Institute (LA BioMed) [MO1 RR00425]; UCLA Clinical and Translational
   Science Institute at Los Angeles Biomedical Research Institute (LA
   BioMed) [1UL1TR000124]; Harbor-UCLA Medical Center; Endocrine,
   Metabolism and Nutrition Training Grant [T32 DK-007571]; Summer Student
   Fellowship Program at LA BioMed
FX The study was supported by a grant from the General Clinical Research
   Center (MO1 RR00425) to L. Nikolaenko and the UCLA Clinical and
   Translational Science Institute (1UL1TR000124) at Los Angeles Biomedical
   Research Institute (LA BioMed) and Harbor-UCLA Medical Center, and the
   Endocrine, Metabolism and Nutrition Training Grant (T32 DK-007571) and
   the Summer Student Fellowship Program at LA BioMed.
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NR 71
TC 30
Z9 33
U1 0
U2 12
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0193-1849
EI 1522-1555
J9 AM J PHYSIOL-ENDOC M
JI Am. J. Physiol.-Endocrinol. Metab.
PD APR
PY 2018
VL 314
IS 4
BP E366
EP E376
DI 10.1152/ajpendo.00124.2017
PG 11
WC Endocrinology & Metabolism; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Physiology
GA GP8OD
UT WOS:000441170000006
PM 28928235
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Thomson, EM
   Pilon, S
   Guénette, J
   Williams, A
   Holloway, AC
AF Thomson, Errol M.
   Pilon, Shinjini
   Guenette, Josee
   Williams, Andrew
   Holloway, Alison C.
TI Ozone modifies the metabolic and endocrine response to glucose:
   Reproduction of effects with the stress hormone corticosterone
SO TOXICOLOGY AND APPLIED PHARMACOLOGY
LA English
DT Article
DE Air pollution; Ozone; Glucose tolerance test; Stress hormone; Metabolic;
   Endocrine
ID FINE PARTICULATE MATTER; LONG-TERM EXPOSURE; INSULIN-RESISTANCE;
   AIR-POLLUTION; CARDIOVASCULAR RISK; SENSITIVITY; OBESITY; TRIGLYCERIDES;
   INFLAMMATION; HOMEOSTASIS
AB Air pollution is associated with increased incidence of metabolic disease (e.g. metabolic syndrome, obesity, diabetes); however, underlying mechanisms are poorly understood. Air pollutants increase the release of stress hormones (human cortisol, rodent corticosterone), which could contribute to metabolic dysregulation. We assessed acute effects of ozone, and stress axis involvement, on glucose tolerance and on the metabolic (triglyceride), endocrine/energy regulation (insulin, glucagon, GLP-1, leptin, ghrelin, corticosterone), and inflammatory/endothelial (TNF, IL-6, VEGF, PAI-1) response to exogenous glucose. Male Fischer-344 rats were exposed to clean air or 0.8 ppm ozone for 4 h in whole body chambers. Hypothalamic-pituitary-adrenal (HPA) axis involvement in ozone effects was tested through subcutaneous administration of the glucocorticoid synthesis inhibitor metyrapone (50 mg/kg body weight), corticosterone (10 mg/kg body weight), or vehicle (40% propylene glycol) prior to exposure. A glucose tolerance test (2 g/kg body weight glucose) was conducted immediately after exposure, with blood samples collected at 0, 30, 60, 90, and 120 min. Ozone exposure impaired glucose tolerance, an effect accompanied by increased plasma triglycerides but no impairment of insulin release. Ozone diminished glucagon, GLP-1, and ghrelin responses to glucose, but did not significantly impact inflammatory/endothelial analytes. Metyrapone reduced corticosterone but increased glucose and triglycerides, complicating evaluation of the impact of glucocorticoid inhibition. However, administration of corticosterone reproduced the profile of ozone effects, supporting a role for the HPA axis. The results show that ozone-dependent changes in glucose tolerance are accompanied by altered metabolic and endocrine responses to glucose challenge that are reproduced by exogenous stress hormone.
C1 [Thomson, Errol M.; Pilon, Shinjini; Guenette, Josee; Williams, Andrew] Hlth Canada, Environm Hlth Sci & Res Bur, Ottawa, ON K1A OK9, Canada.
   [Holloway, Alison C.] McMaster Univ, Dept Obstet & Gynecol, Hamilton, ON L8N 3Z5, Canada.
C3 Health Canada; McMaster University
RP Thomson, EM (corresponding author), Hlth Canada, Environm Hlth Sci & Res Bur, Hazard Identificat Div, Inhalat Toxicol Lab, 0802B Tunneys Pasture, Ottawa, ON K1A OK9, Canada.
EM errol.thomson@canada.ca; shinjini.pilon@canada.ca;
   josee.guenette@canada.ca; andrew.williams@canada.ca; hollow@mcmaster.ca
RI williams, anthony/HPE-7348-2023
OI Williams, Andrew/0000-0002-7637-7686; Thomson, Errol/0000-0003-1295-5384
FU Health Canada (Clean Air Regulatory Agenda) [810504]
FX We wish to acknowledge the technical assistance of Kevin Curtin, Alain
   Filiatreault, Marjolaine Godbout-Cheliak, Karine Chamberland, Michelle
   Lalande, Scott Smith, Cina Aghazadeh Sanaei, and Bruce Martin. Thanks to
   Dr. Azam Tayabali and Dr. Dalibor Breznan for helpful comments in
   reviewing the manuscript. This work was supported by Health Canada
   (Clean Air Regulatory Agenda, project number 810504).
CR Ahrén B, 2006, DIABETOLOGIA, V49, P117, DOI 10.1007/s00125-005-0056-8
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NR 52
TC 21
Z9 22
U1 0
U2 10
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0041-008X
EI 1096-0333
J9 TOXICOL APPL PHARM
JI Toxicol. Appl. Pharmacol.
PD MAR 1
PY 2018
VL 342
BP 31
EP 38
DI 10.1016/j.taap.2018.01.020
PG 8
WC Pharmacology & Pharmacy; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Toxicology
GA FY4OY
UT WOS:000426805600004
PM 29391239
OA hybrid
DA 2025-06-11
ER

PT J
AU Halima, B
   Sonia, G
   Sarra, K
   Houda, B
   Fethi, B
   Abdallah, A
AF Halima, Ben Hmad
   Sonia, Gara
   Sarra, Khlifi
   Houda, Ben Jemaa
   Fethi, Ben Slama
   Abdallah, Aouidet
TI Apple Cider Vinegar Attenuates Oxidative Stress and Reduces the Risk of
   Obesity in High-Fat-Fed Male Wistar Rats
SO JOURNAL OF MEDICINAL FOOD
LA English
DT Article
DE atherogenic index; lipid profile; oxidative stress; vinegar
ID DENSITY-LIPOPROTEIN CHOLESTEROL; DIET-INDUCED OBESITY; ACETIC-ACID;
   ADIPOSE-TISSUE; ANTIOXIDANT ENZYMES; INSULIN RESPONSES;
   ALPHA-TOCOPHEROL; GLYCEMIC INDEX; SERUM; LIVER
AB Metabolic syndrome is a serious consequence of obesity characterized by increased cardiovascular risk factors such as hypertension, dyslipidemia, and glucose intolerance. While diets enriched with natural antioxidants showed beneficial effects on oxidative stress, blood pressure, and serum lipid composition, diet supplementation with synthetic antioxidants showed contradictive results. Thus, we tested, in this study, whether a daily dosage of Apple Cider Vinegar (ACV) would affect cardiovascular risk factor associated with obesity in high-fat diet (HFD)-induced hyperlipidemic Wistar rats. Obese rats showed increased serum total cholesterol, triglyceride, low-density lipoprotein-cholesterol (LDL-C), very low density lipoprotein (VLDL) and atherogenic index after 6 and 9 weeks of being fed an HFD. Importantly, ACV ameliorated all of these parameters significantly. Oxidative stress already developed after 6 weeks of HFD and was significantly reduced by daily doses of ACV. Oral administration of ACV normalized various biochemical and metabolic changes since it exhibited a very significant (P < .001) reduction in malondialdehyde levels, whereas an increase in thiol group concentrations and antioxidant status (superoxide dismutase [SOD], glutathione peroxidase [GPx], and catalase [CAT] activities and vitamin E concentrations). In addition, a modulation in trace element levels was observed when compared with HFD groups. These findings suggested that HFD alters the oxidant-antioxidant balance, as evidenced by a reduction in the antioxidant enzyme activities and vitamin E level, and enhanced lipid peroxidation. ACV can be beneficial for the suppression of obesity-induced oxidative stress in HFD rats through the modulating antioxidant defense system and reduces the risk of obesity-associated diseases by preventing the atherogenic risk.
C1 [Halima, Ben Hmad; Sarra, Khlifi; Houda, Ben Jemaa; Fethi, Ben Slama; Abdallah, Aouidet] Univ Tunis El Manar, High Sch Hlth Sci, Res Unit Nutr Regulat Metab Syst & Atherosclerosi, Tunis, Tunisia.
   [Sonia, Gara] Inst Salah Azaiz, Lab Clin Biochem, Tunis, Tunisia.
C3 Universite de Tunis-El-Manar; Universite de Tunis-El-Manar; Institut
   Salah Azaiez
RP Halima, B (corresponding author), ESSTT, UR Nutr Regulat Metab Syst & Atherosclerosis, BP 176, Tunis 1007, Tunisia.
EM ahlem2014benhmad@gmail.com
FU Tunisian Ministry of High Education and Scientific Research and
   Technology
FX We are thankful to the Tunisian Ministry of High Education and
   Scientific Research and Technology for providing financial assistance
   and to the Tunisian Ministry of Public Health for providing the
   facilities to carry out this work.
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TC 41
Z9 43
U1 2
U2 29
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1096-620X
EI 1557-7600
J9 J MED FOOD
JI J. Med. Food
PD JAN
PY 2018
VL 21
IS 1
BP 70
EP 80
DI 10.1089/jmf.2017.0039
EA NOV 2017
PG 11
WC Chemistry, Medicinal; Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Food Science & Technology; Nutrition &
   Dietetics
GA FX3NU
UT WOS:000414336700001
PM 29091513
DA 2025-06-11
ER

PT J
AU Chirumbolo, S
   Bjorklund, G
AF Chirumbolo, Salvatore
   Bjorklund, Geir
TI PERM Hypothesis: The Fundamental Machinery Able to Elucidate the Role of
   Xenobiotics and Hormesis in Cell Survival and Homeostasis
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE mitochondria; proterome; reactive oxygen species (ROS); oxidative
   stress; flavonoids
ID ENDOPLASMIC-RETICULUM STRESS; MITOCHONDRIAL LON PROTEASE; NF-KAPPA-B;
   MAHOGUNIN RING FINGER-1; OXIDATIVE STRESS; 26S PROTEASOME; INDUCED
   APOPTOSIS; INFLAMMATORY RESPONSES; DEPENDENT APOPTOSIS;
   IONIZING-RADIATION
AB In this article the Proteasome, Endoplasmic Reticulum and Mitochondria (PERM) hypothesis is discussed. The complex machinery made by three homeostatic mechanisms involving the proteasome (P), endoplasmic reticulum (ER) and mitochondria (M) is addressed in order to elucidate the beneficial role of many xenobiotics, either trace metals or phytochemicals, which are spread in the human environment and in dietary habits, exerting their actions on the mechanisms underlying cell survival (apoptosis, cell cycle regulation, DNA repair and turnover, autophagy) and stress response. The "PERM hypothesis" suggests that xenobiotics can modulate this central signaling and the regulatory engine made fundamentally by the ER, mitochondria and proteasome, together with other ancillary components such as peroxisomes, by acting on the energetic balance, redox system and macromolecule turnover. In this context, reactive species and stressors are fundamentally signalling molecules that could act as negative-modulating signals if PERM-mediated control is offline, impaired or dysregulated, as occurs in metabolic syndrome, degenerative disorders, chronic inflammation and cancer. Calcium is an important oscillatory input of this regulation and, in this hypothesis, it might play a role in maintaining the correct rhythm of this PERM modulation, probably chaotic in its nature, and guiding cells to a more drastic decision, such as apoptosis. The commonest effort sustained by cells is to maintain their survival balance and the proterome has the fundamental task of supporting this mechanism. Mild stress is probably the main stimulus in this sense. Hormesis is therefore re-interpreted in the light of this hypothetical model and that experimental evidence arising from flavonoid and hormesis reasearch.
C1 [Chirumbolo, Salvatore] Univ Verona, Dept Neurol & Movement Sci, I-37134 Verona, Italy.
   [Bjorklund, Geir] Council Nutr & Environm Med, N-8610 Mo I Rana, Norway.
C3 University of Verona
RP Chirumbolo, S (corresponding author), Univ Verona, Dept Neurol & Movement Sci, I-37134 Verona, Italy.
EM salvatore.chirumbolo@univr.it; bjorklund@conem.org
RI Chirumbolo, Salvatore/AGF-1981-2022; Chirumbolo, Salvatore/L-6865-2016;
   Bjorklund, Geir/B-7319-2014
OI Chirumbolo, Salvatore/0000-0003-1789-8307; Bjorklund,
   Geir/0000-0003-2632-3935
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NR 139
TC 41
Z9 42
U1 0
U2 14
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD JAN
PY 2017
VL 18
IS 1
AR 165
DI 10.3390/ijms18010165
PG 18
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA EJ2HL
UT WOS:000393030600163
PM 28098843
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Kars, M
   Yang, L
   Gregor, MF
   Mohammed, BS
   Pietka, TA
   Finck, BN
   Patterson, BW
   Horton, JD
   Mittendorfer, B
   Hotamisligil, GS
   Klein, S
AF Kars, Marleen
   Yang, Ling
   Gregor, Margaret F.
   Mohammed, B. Selma
   Pietka, Terri A.
   Finck, Brian N.
   Patterson, Bruce W.
   Horton, Jay D.
   Mittendorfer, Bettina
   Hotamisligil, Goekhan S.
   Klein, Samuel
TI Tauroursodeoxycholic Acid May Improve Liver and Muscle but Not Adipose
   Tissue Insulin Sensitivity in Obese Men and Women
SO DIABETES
LA English
DT Article
ID ENDOPLASMIC-RETICULUM STRESS; NONALCOHOLIC FATTY LIVER;
   CORONARY-HEART-DISEASE; BILE-ACIDS; NONDIABETIC SUBJECTS;
   GLUCOSE-HOMEOSTASIS; METABOLIC SYNDROME; DIABETES-MELLITUS; HEPATIC
   STEATOSIS; IN-VIVO
AB OBJECTIVE-Insulin resistance is commonly associated with obesity. Studies conducted in obese mouse models found that endoplasmic reticulum (ER) stress contributes to insulin resistance, and treatment with tauroursodeoxycholic acid (TUDCA), a bile acid derivative that acts as a chemical chaperone to enhance protein folding and ameliorate ER stress, Increases Insulin sensitivity. The purpose of this study was to determine the effect of TUDCA therapy on multiorgan insulin action and metabolic factors associated with insulin resistance in obese men and women
   RESEARCH DESIGN AND METHODS-Twenty obese subjects ([means +/- SD] aged 48 +/- 11 years, BMI 37 +/- 4 kg/m(2)) were randomized to 4 weeks of treatment with TUDCA (1,750 mg/day) or placebo. A two-stage hyperinsulinemic-euglycemic clamp procedure in conjunction with stable isotopically labeled tracer infusions and muscle and adipose tissue biopsies were used to evaluate in vivo insulin sensitivity, cellular factors involved in insulin signaling, and cellular markers of ER stress.
   RESULTS-Hepatic and muscle insulin sensitivity increased by similar to 30% (P < 0 05) after treatment with TUDCA but; did not change after placebo therapy. In addition, therapy with TUDCA, but not placebo, increased muscle insulin signaling (phosphorylated insulin receptor substrate(Tyr) and Akt(Ser473) levels) (P < 0.05). Markers of ER stress in muscle or adipose tissue did not change after treatment with either TUDCA or placebo
   CONCLUSIONS-These data demonstrate that TUDCA might. be an effective pharmacological approach for treating insulin resistance Additional studies are needed to evaluate the target cells and mechanisms responsible for this effect. Diabetes 59: 1899-1905, 2010
C1 [Kars, Marleen; Mohammed, B. Selma; Pietka, Terri A.; Finck, Brian N.; Patterson, Bruce W.; Mittendorfer, Bettina; Klein, Samuel] Washington Univ, Sch Med, Ctr Human Nutr, St Louis, MO 63130 USA.
   [Kars, Marleen; Mohammed, B. Selma; Pietka, Terri A.; Finck, Brian N.; Patterson, Bruce W.; Mittendorfer, Bettina; Klein, Samuel] Washington Univ, Sch Med, Atkins Ctr Excellence Obes Med, St Louis, MO USA.
   [Yang, Ling; Gregor, Margaret F.; Hotamisligil, Goekhan S.] Harvard Univ, Sch Publ Hlth, Dept Genet & Complex Dis, Boston, MA 02115 USA.
   [Horton, Jay D.] Univ Texas SW Med Ctr Dallas, Dept Internal Med, Dallas, TX 75390 USA.
C3 Washington University (WUSTL); Washington University (WUSTL); Harvard
   University; Harvard T.H. Chan School of Public Health; University of
   Texas System; University of Texas Southwestern Medical Center Dallas
RP Klein, S (corresponding author), Washington Univ, Sch Med, Ctr Human Nutr, St Louis, MO 63130 USA.
RI Hotamisligil, Gokhan/ABL-2919-2022; Yang, Ling/C-8000-2011; Klein,
   Samuel/HLX-8445-2023
OI Yang, Ling/0000-0002-3105-3063; Finck, Brian/0000-0001-5411-3674;
   Patterson, Bruce W/0000-0001-9261-0233
FU National Institutes of Health [DK 37948, DK52539]; Nutrition Obesity
   Research Center [DK 56341]; Biomedical Mass Spectrometry Resource [RR
   00954]; Institute for Clinical and Translational Science [UL1 RR024992];
   Environmental Health Training grant [T32 ES007155-24]; Nutricia Research
   Foundation; Syndexa Pharmaceuticals; American Diabetes Association;
   Donald and Sue Pritzker Scholar award
FX This study was supported by National Institutes of Health Grants DK
   37948, DK52539, DK 56341 (Nutrition Obesity Research Center), RR 00954
   (Biomedical Mass Spectrometry Resource), UL1 RR024992 (Institute for
   Clinical and Translational Science), and T32 ES007155-24 (Environmental
   Health Training grant). This study also received support from the
   Nutricia Research Foundation (2009-26), Syndexa Pharmaceuticals, a
   mentor-based postdoctoral fellowship from the American Diabetes
   Association, and a Donald and Sue Pritzker Scholar award.
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NR 49
TC 327
Z9 360
U1 0
U2 17
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0012-1797
J9 DIABETES
JI Diabetes
PD AUG
PY 2010
VL 59
IS 8
BP 1899
EP 1905
DI 10.2337/db10-0308
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 636PA
UT WOS:000280749100008
PM 20522594
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Kelly, AS
   Thelen, AM
   Kaiser, DR
   Gonzalez-Campoy, JM
   Bank, AJ
AF Kelly, Aaron S.
   Thelen, Andrea M.
   Kaiser, Daniel R.
   Gonzalez-Campoy, J. Michael
   Bank, Alan J.
TI Rosiglitazone improves endothelial function and inflammation but not
   asymmetric dimethylarginine or oxidative stress in patients with type 2
   diabetes mellitus
SO VASCULAR MEDICINE
LA English
DT Article
DE asymmetric dimethylarginine; endothelial function; oxidative stress;
   rosiglitazone; type 2 diabetes mellitus
ID CORONARY STENT IMPLANTATION; INTIMA-MEDIA THICKNESS; C-REACTIVE PROTEIN;
   NONDIABETIC PATIENTS; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   CARDIOVASCULAR-DISEASE; ARTERIAL STIFFNESS; GAMMA ACTIVATION; GLYCEMIC
   CONTROL
AB We compared the vascular effects of rosiglitazone versus glyburide and evaluated asymmetric dimethylarginine (ADMA) and oxidative stress as potential mechanisms associated with changes in vascular health in patients with type 2 diabetes mellitus (T2DM). Patients were randomized to 6 months of either rosiglitazone (n = 20) or glyburide (n = 16) in addition to metformin. The following variables were measured pre- and post-treatment: glucose, insulin, homeostasis model assessment (HOMA), hemoglobin A1c (HbA1c), C-peptide, blood pressure, lipids, C-reactive protein (CRP), ADMA, 8-isoprostane, oxidized LDL cholesterol, brachial artery flow-mediated dilation (FMD), endothelium-independent dilation (EID), and brachial and carotid artery stiffness. Rosiglitazone and glyburide treatment resulted in significant and equivalent decreases in glucose (p < 0.0001) and HbA1c (p < 0.0001), with a trend toward decreased HOMA (p = 0.09). Rosiglitazone significantly decreased C-peptide (p < 0.01) with a strong trend toward decreased fasting insulin (p = 0.05). Rosiglitazone reduced CRP compared with glyburide (p = 0.001), but no differences were observed between groups for ADMA or the markers of oxidative stress. Rosiglitazone significantly improved FIVID (p < 0.05) with trends toward improvements in carotid artery distension (p = 0.099) and distensibility (p = 0.078). In conclusion, compared with glyburide, rosiglitazone improves endothelial function and CRP in patients with T2DM. These improvements are not associated with reductions in ADMA or markers of oxidative stress.
C1 [Kelly, Aaron S.; Thelen, Andrea M.; Bank, Alan J.] St Paul Heart Clin, Dept Res, St Paul, MN USA.
   [Kelly, Aaron S.; Kaiser, Daniel R.; Bank, Alan J.] Univ Minnesota, Sch Med, Minneapolis, MN 55455 USA.
   [Gonzalez-Campoy, J. Michael] Minnesota Ctr Obes Metab & Endocrinol, Eagan, MN USA.
C3 University of Minnesota System; University of Minnesota Twin Cities
RP Kelly, AS (corresponding author), 225 Smith Ave N,Suite 400, St Paul, MN 55102 USA.
EM kelly105@umn.edu
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NR 38
TC 57
Z9 60
U1 0
U2 3
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1358-863X
J9 VASC MED
JI Vasc. Med.
PY 2007
VL 12
IS 4
BP 311
EP 318
DI 10.1177/1358863x07084200
PG 8
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 248VR
UT WOS:000252185700006
PM 18048467
DA 2025-06-11
ER

PT J
AU Fedoseeva, LA
   Klimov, LO
   Ershov, NI
   Alexandrovich, YV
   Efimov, VM
   Markel, AL
   Redina, OE
AF Fedoseeva, Larisa A.
   Klimov, Leonid O.
   Ershov, Nikita I.
   Alexandrovich, Yury V.
   Efimov, Vadim M.
   Markel, Arcady L.
   Redina, Olga E.
TI Molecular determinants of the adrenal gland functioning related to
   stress-sensitive hypertension in ISIAH rats
SO BMC GENOMICS
LA English
DT Article; Proceedings Paper
CT 10th International Conference on Bioinformatics of Genome Regulation and
   Structure\Systems Biology (BDRS\SB)
CY AUG 29-SEP 02, 2016
CL Russian Acad Sci, Siberian Branch, Inst Cytol & Genet, Novosibirsk,
   RUSSIA
HO Russian Acad Sci, Siberian Branch, Inst Cytol & Genet
DE Stress-sensitive hypertension; Adrenal gland; Transcriptional profiling;
   RNA-Seq; PLS-DA; ISIAH rats
ID INDUCED ARTERIAL-HYPERTENSION; BLOOD-PRESSURE REGULATION; PARTIAL
   LEAST-SQUARES; LARGE GENE LISTS; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   TRANSCRIPTOME ANALYSIS; PPARGAMMA ACTIVATION; DIABETES-MELLITUS;
   PROTEASE NEXIN-1
AB Background: The adrenals are known as an important link in pathogenesis of arterial hypertensive disease. The study was directed to the adrenal transcriptome analysis in ISIAH rats with stress-sensitive arterial hypertension and predominant involvement in pathogenesis of the hypothalamic-pituitary-adrenal and sympathoadrenal systems.
   Results: The RNA-Seq approach was used to perform the comparative adrenal transcriptome profiling in hypertensive ISIAH and normotensive WAG rats. Multiple differentially expressed genes (DEGs) related to different biological processes and metabolic pathways were detected. The discussion of the results helped to prioritize the several DEGs as the promising candidates for further studies of the genetic background underlying the stress-sensitive hypertension development in the ISIAH rats. Two of these were transcription factor genes (Nr4a3 and Ppard), which may be related to the predominant activation of the sympathetic-adrenal medullary axis in ISIAH rats. The other genes are known as associated with hypertension and were defined in the current study as DEGs making the most significant contribution to the inter-strain differences. Four of them (Avpr1a, Hsd11b2, Agt, Ephx2) may provoke the hypertension development, and Mpo may contribute to insulin resistance and inflammation in the ISIAH rats.
   Conclusions: The study strongly highlighted the complex nature of the pathogenesis of stress-sensitive hypertension. The data obtained may be useful for identifying the common molecular determinants in different animal models of arterial hypertension, which may be potentially used as therapeutic targets for pharmacological intervention.
C1 [Fedoseeva, Larisa A.; Klimov, Leonid O.; Ershov, Nikita I.; Alexandrovich, Yury V.; Efimov, Vadim M.; Markel, Arcady L.; Redina, Olga E.] Russian Acad Sci, Inst Cytol & Genet, Siberian Branch, Novosibirsk, Russia.
   [Efimov, Vadim M.; Markel, Arcady L.] Novosibirsk State Univ, Novosibirsk, Russia.
C3 Russian Academy of Sciences; Siberian Branch of the Russian Academy of
   Sciences; Institute of Cytology & Genetics ICG SB RAS; Novosibirsk State
   University
RP Redina, OE (corresponding author), Russian Acad Sci, Inst Cytol & Genet, Siberian Branch, Novosibirsk, Russia.
EM oredina@ngs.ru
RI Ershov, Nikita/F-7484-2017; Efimov, Vadim/AAE-1158-2020; Redina,
   Olga/T-1650-2017; Klimov, Leonid/F-5306-2017; Fedoseeva,
   Larisa/ABA-9889-2020; Efimov, Vadim/K-5806-2012
OI Efimov, Vadim/0000-0003-3035-8049; Redina, Olga/0000-0003-0942-8460
FU Russian Science Foundation [14-15-00118]; Russian Science Foundation
   [14-15-00118] Funding Source: Russian Science Foundation
FX Publication of this article has been funded by the Russian Science
   Foundation (grant 14-15-00118).
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NR 82
TC 18
Z9 19
U1 0
U2 5
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-2164
J9 BMC GENOMICS
JI BMC Genomics
PY 2016
VL 17
AR 989
DI 10.1186/s12864-016-3354-2
PG 20
WC Biotechnology & Applied Microbiology; Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Biotechnology & Applied Microbiology; Genetics & Heredity
GA FN5UR
UT WOS:000416074600001
PM 28105924
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Barr, LA
   Shimizu, Y
   Lambert, JP
   Nicholson, CK
   Calvert, JW
AF Barr, Larry A.
   Shimizu, Yuuki
   Lambert, Jonathan P.
   Nicholson, Chad K.
   Calvert, John W.
TI Hydrogen sulfide attenuates high fat diet-induced cardiac dysfunction
   via the suppression of endoplasmic reticulum stress
SO NITRIC OXIDE-BIOLOGY AND CHEMISTRY
LA English
DT Article
DE Diabetes; Diabetic cardiomyopathy; Hydrogen sulfide; ER stress
ID ISCHEMIA-REPERFUSION INJURY; INDUCED HEART-FAILURE; OXIDATIVE STRESS;
   DIABETIC CARDIOMYOPATHY; ER STRESS; PROTECTS; ACTIVATION;
   CARDIOPROTECTION; APOPTOSIS; H2S
AB Diabetic cardiomyopathy is a significant contributor to the morbidity and mortality associated with diabetes and metabolic syndrome. However, the underlying molecular mechanisms that lead to its development have not been fully elucidated. Hydrogen sulfide (H2S) is an endogenously produced signaling molecule that is critical for the regulation of cardiovascular homeostasis. Recently, therapeutic strategies aimed at increasing its levels have proven cardioprotective in models of acute myocardial ischemia-reperfusion injury and heart failure. The precise role of H2S in the pathogenesis of diabetic cardiomyopathy has not yet been established. Therefore, the goal of the present study was to evaluate circulating and cardiac H2S levels in a murine model of high fat diet (HFD)-induced cardiomyopathy. Diabetic cardiomyopathy was produced by feeding mice HFD (60% fat) chow for 24 weeks. HFD feeding reduced both circulating and cardiac H2S and induced hallmark features of type-2 diabetes. We also observed marked cardiac dysfunction, evidence of cardiac enlargement, cardiac hypertrophy, and fibrosis. H2S therapy (SG-1002, an orally active H2S donor) restored sulfide levels, improved some of the metabolic perturbations stemming from HFD feeding, and attenuated HFD-induced cardiac dysfunction. Additional analysis revealed that H2S therapy restored adiponectin levels and suppressed cardiac ER stress stemming from HFD feeding. These results suggest that diminished circulating and cardiac H2S levels play a role in the pathophysiology of HFD-induced cardiomyopathy. Additionally, these results suggest that H2S therapy may be of clinical importance in the treatment of cardiovascular complications stemming from diabetes. (C) 2014 Elsevier Inc. All rights reserved.
C1 [Barr, Larry A.; Shimizu, Yuuki; Lambert, Jonathan P.; Nicholson, Chad K.; Calvert, John W.] Emory Univ, Sch Med, Carlyle Fraser Heart Ctr, Dept Surg,Div Cardiothorac Surg, Atlanta, GA 30313 USA.
C3 Emory University
RP Calvert, JW (corresponding author), Emory Univ, Sch Med, Carlyle Fraser Heart Ctr, Dept Surg,Div Cardiothorac Surg, 380 Northyards Blvd,Suite B, Atlanta, GA 30313 USA.
EM jcalver@emory.edu
RI ; Lambert, Jonathan/P-1766-2018; Calvert, John/F-4497-2014
OI Shimizu, Yuuki/0000-0003-3103-1160; Lambert,
   Jonathan/0000-0001-7048-6841; Calvert, John/0000-0001-6858-6042
FU National Institutes of Health, National Heart, Lung, and Blood Institute
   [5R01HL098481-05]; Carlyle Fraser Heart Center of Emory University
   Hospital Midtown
FX This work was supported by a grant from the National Institutes of
   Health, National Heart, Lung, and Blood Institute (5R01HL098481-05) to
   J.W.C. This work was also supported by funding from the Carlyle Fraser
   Heart Center of Emory University Hospital Midtown.
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NR 63
TC 91
Z9 98
U1 0
U2 23
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 1089-8603
EI 1089-8611
J9 NITRIC OXIDE-BIOL CH
JI Nitric Oxide-Biol. Chem.
PD APR 30
PY 2015
VL 46
SI SI
BP 145
EP 156
DI 10.1016/j.niox.2014.12.013
PG 12
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA CE0GY
UT WOS:000351483700018
PM 25575644
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Stubbins, RE
   Najjar, K
   Holcomb, VB
   Hong, J
   Núñez, NP
AF Stubbins, R. E.
   Najjar, K.
   Holcomb, V. B.
   Hong, J.
   Nunez, N. P.
TI Oestrogen alters adipocyte biology and protects female mice from
   adipocyte inflammation and insulin resistance
SO DIABETES OBESITY & METABOLISM
LA English
DT Article
DE adipose tissue; inflammation; insulin resistance; obesity; oestrogen;
   sex
ID ADIPOSE-TISSUE; METABOLIC SYNDROME; ENDOTHELIAL-CELLS; OXIDATIVE STRESS;
   SKELETAL-MUSCLE; RECEPTOR-ALPHA; KNOCKOUT MICE; EXPRESSION; OBESITY;
   WOMEN
AB Aims: Obesity is associated with insulin resistance, liver steatosis and low-grade inflammation. The role of oestrogen in sex differences in the above co-morbidities is not fully understood. Our aim was to assess the role oestrogen has in modulating adipocyte size, adipose tissue oxidative stress, inflammation, insulin resistance and liver steatosis.
   Methods: To determine the role oestrogen has in the above co-morbidities related to obesity, we randomized C57BL/6J mice into four groups (15 mice per group): (i) male, (ii) non-ovariectomized female (novx), (iii) ovariectomized female (ovx) and (iv) ovariectomized female mice supplemented with 17 beta estradiol (ovx-E). Mice received either a low-fat (LF) or a high-fat (HF) diet for 10 weeks. Outcomes measured were bodyweight, body fat, adipocyte diameter, adipose tissue lipolysis markers, adipose tissue oxidative stress, inflammation, insulin resistance and liver steatosis.
   Results: Male and ovx-female mice consuming the HF diet had a higher propensity of gaining weight, specifically in the form of body fat. Oestrogen protected female mice from adipocyte hypertrophy and from developing adipose tissue oxidative stress and inflammation. Moreover, novx-female and ovx-female+E mice had higher phosphorylated levels of protein kinase A and hormone sensitive lipase, markers associated with lipolysis. Additionally, male and ovx female mice had a higher propensity of developing liver steatosis and insulin resistance. In contrast, oestrogen protected female mice from developing liver steatosis and from becoming insulin resistant.
   Conclusion: We show that oestrogen protects female mice from adipocyte hypertrophy and adipose tissue oxidative stress and inflammation. Furthermore, oestrogen prevented female mice from developing liver steatosis and from becoming insulin resistant.
C1 [Stubbins, R. E.; Najjar, K.; Holcomb, V. B.; Hong, J.; Nunez, N. P.] Univ Texas Austin, Dept Nutr Sci, Austin, TX 78712 USA.
C3 University of Texas System; University of Texas Austin
RP Núñez, NP (corresponding author), Univ Texas Austin, Dept Nutr Sci, 1 Univ Stn,A2703, Austin, TX 78712 USA.
EM nomeli@mail.utexas.edu
FU American Cancer Society [ACS RSG CNE-113703]; National Institutes of
   Health: National Cancer Society [NCI 1K22CA127519-01A1]; National
   Institutes of Health: National Institute of Environmental Health
   Sciences Center [ES09145, ES007784]
FX This work was supported by American Cancer Society grant ACS RSG
   CNE-113703 and by grants from the National Institutes of Health:
   National Cancer Society grant NCI 1K22CA127519-01A1 and National
   Institute of Environmental Health Sciences Center grants ES09145 and
   ES007784.
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NR 33
TC 157
Z9 177
U1 1
U2 14
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1462-8902
J9 DIABETES OBES METAB
JI Diabetes Obes. Metab.
PD JAN
PY 2012
VL 14
IS 1
BP 58
EP 66
DI 10.1111/j.1463-1326.2011.01488.x
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 862AW
UT WOS:000298063200008
PM 21834845
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Gutiérrez-Perez, ME
   Urraza-Robledo, AI
   Miranda-Pérez, AA
   Molina-Flores, CA
   Ruíz-Flores, P
   Delgadillo-Guzmán, D
   López-Márquez, FC
AF Elena Gutierrez-Perez, Maria
   Ivonne Urraza-Robledo, Arguine
   Alejandro Miranda-Perez, Alberto
   Anali Molina-Flores, Cinthia
   Ruiz-Flores, Pablo
   Delgadillo-Guzman, Dealmy
   Carlos Lopez-Marquez, Francisco
TI Role of β-Klotho and Malondialdehyde in Metabolic Disorders, HIV
   Infection, and Antiretroviral Therapy
SO DNA AND CELL BIOLOGY
LA English
DT Article
DE beta-klotho; oxidative stress; HIV; metabolic disorder
ID OXIDATIVE STRESS; INSULIN-RESISTANCE; EVENTS; GENE
AB Metabolic alterations, resulting from factors such as obesity or infections (HIV), generate inflammation in the body, affecting the immune system and causing oxidative stress. Prolonged exposure to antiretroviral therapy (ART) conditions the appearance of alterations considered risk factors for metabolic syndrome (MetS), affecting the quality of life in people living with HIV/AIDS (PLWHA). beta-klotho is a protein that can counteract levels of oxidative stress. The aim was to determine the relation of beta-klotho and oxidative stress with metabolic alterations in PLWHA. We hypothesized that levels of beta-klotho and malondialdehyde (MDA) are related in PLWHA on ART with overweight/obesity. As a result of comparing cases versus controls, significant differences were obtained in levels of beta-klotho (p = 0.011), MDA (p < 0.0001), body mass index (p = 0.001), and weight (p < 0.0001). The presence of MetS in PLWHA was 21.2% and 10.6% according to the World Health Organization and ATP III (National Cholesterol Education Program Adult Treatment Panel III) criteria, respectively. The founded correlations were of beta-klotho (r = 0.019) and MDA (r = 0.0001), both with CD4+ cells in PLWHA. In controls, beta-klotho was correlated with very low-density lipoprotein (r = 0.035) and atherogenic index (AI; r = 0.037), MDA with AI (r = 0.039), cholesterol, and low-density lipoprotein (r = 0.002). The increase of inflammation in the organism, owing to HIV infection and/or the presence of obesity, conditions metabolic disruption or depletion of elements needed for homeostasis in the human body.
C1 [Elena Gutierrez-Perez, Maria; Ivonne Urraza-Robledo, Arguine; Alejandro Miranda-Perez, Alberto; Anali Molina-Flores, Cinthia; Carlos Lopez-Marquez, Francisco] Autonomous Univ Coahuila, Fac Med, Biomed Res Ctr, Dept Mol Immunobiol, C Gregorio A Garcia 198, Torreon 27000, Mexico.
   [Ivonne Urraza-Robledo, Arguine] Mexican Social Secur Inst IMSS, Dept Diagnost Aids Div, High Specialty Med Unit UMAE, Torreon, Mexico.
   [Ruiz-Flores, Pablo] Autonomous Univ Coahuila, Fac Med, Biomed Res Ctr, Dept Mol Med & Genet, Torreon, Mexico.
   [Delgadillo-Guzman, Dealmy] Autonomous Univ Coahuila, Fac Med, Biomed Res Ctr, Dept Pharmacol, Torreon, Mexico.
C3 Universidad Autonoma de Coahuila; Instituto Mexicano del Seguro Social;
   Universidad Autonoma de Coahuila; Universidad Autonoma de Coahuila
RP López-Márquez, FC (corresponding author), Autonomous Univ Coahuila, Fac Med, Biomed Res Ctr, Dept Mol Immunobiol, C Gregorio A Garcia 198, Torreon 27000, Mexico.
RI Delgadillo, Dealmy/KHV-1935-2024
FU Fund for Scientific and Technological Research (FON-CYT)
   [COAH-2019-C13-C054]
FX Fund for Scientific and Technological Research (FON-CYT)
   COAH-2019-C13-C054
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NR 46
TC 3
Z9 3
U1 0
U2 1
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1044-5498
EI 1557-7430
J9 DNA CELL BIOL
JI DNA Cell Biol.
PD JUL 1
PY 2022
VL 41
IS 7
BP 691
EP 698
DI 10.1089/dna.2021.1052
PG 8
WC Biochemistry & Molecular Biology; Cell Biology; Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology; Genetics & Heredity
GA 7T1KC
UT WOS:000911205500002
PM 35793534
DA 2025-06-11
ER

PT J
AU Khedr, Y
   Badran, M
AF Khedr, Yasser
   Badran, Mahmoud
TI ASSESSMENT OF LEVELS OF SELECTED TRACE ELEMENTS AS PREDICTORS OF
   OXIDATIVE STRESS IN TYPE 2 DIABETIC PATIENTS USING MULTIVARIATE
   STATISTICAL ANALYSIS
SO JOURNAL OF ELEMENTOLOGY
LA English
DT Article
DE type 2 diabetes; trace elements; oxidative stress; ROC curve; VIP score
ID ENZYME-ACTIVITY; METABOLIC SYNDROME; ANTIOXIDANT
AB Disturbances in levels of trace elements and oxidative stress are associated with the glycemic status, which is implicated in the development and progression of diabetes. The present study was conducted on 50 patients with type 2 diabetes, 40 years of age, gender and body mass index matched with healthy controls (Damanhur Educational Hospital, El Beheira, Egypt). Fasting blood glucose (FBG), serum catalase, paraoxonase activity. and malondialdehyde (MDA) levels were measured spectrophotometrically. The blood serum was digested and then used to determine the levels of seven trace elements, such as Cr, Fe, Cu, Zn, Cd, As and Se, using inductive coupled plasma mass spectroscopy (ICP-MS). The mean of serum catalase. paraoxonase activities and the concentration of Fe, Se, Zn, and Cd were significantly decreased, whereas the level of malondialdehyde (MDA) and the concentrations of Cu, Cd and As were significantly higher in type 2 diabetic group compared with the control group. The multivariate receiver operating characteristic (ROC) curve and variable importance in projection (VIP) scores were used to analysis the data. VIP score revealed that As. Fe and Se were strongly associated with the oxidative stress in type 2 diabetic patients. The best cut-off values for serum concentrations of Fe, Se and As were 46.78. 215 and 1.01 mu g L-1, respectively, which discriminated between diabetic patients with oxidative stress from the control group. The study showed that changes in trace element concentrations in diabetic patients may contribute to the lowering of antioxidant enzymes t, further leading to the progress of T2DM.
C1 [Khedr, Yasser] Damanhour Univ, Phys Dept, Damanhour, Egypt.
   [Badran, Mahmoud] Alexandria Univ, Dept Med Biophys, Alexandria, Egypt.
C3 Egyptian Knowledge Bank (EKB); Damanhour University; Egyptian Knowledge
   Bank (EKB); Alexandria University
RP Khedr, Y (corresponding author), Damanhour Univ, Phys Dept, Med Biophys, Fac Sci, Damanhour, Egypt.
EM yasserkhedr2001@sci.dmu.edu.com
RI Khedr, Yasser/HZK-1157-2023
CR [Anonymous], J COLL MED SCI NEPAL
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NR 25
TC 1
Z9 1
U1 0
U2 2
PU POLISH SOCIETY MAGNESIUM RESEARCH
PI OLSZYTN
PA UNIV WARMIA-MAZURY OLSZTYN, PLAC LODZKI 2, OLSZYTN, PLS 10-957, POLAND
SN 1644-2296
J9 J ELEMENTOL
JI J. Elem.
PY 2021
VL 26
IS 1
BP 47
EP 58
DI 10.5601/jelem.2020.25.3.1995
PG 12
WC Environmental Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology
GA QG8YY
UT WOS:000617867800002
DA 2025-06-11
ER

PT J
AU Ebrahimi-Mameghani, M
   Jamali, H
   Mahdavi, R
   Kakaei, F
   Abedi, R
   Kabir-Mamdooh, B
AF Ebrahimi-Mameghani, Mehrangiz
   Jamali, Haleh
   Mahdavi, Reza
   Kakaei, Farzad
   Abedi, Rana
   Kabir-Mamdooh, Bita
TI Conjugated linoleic acid improves glycemic response, lipid profile, and
   oxidative stress in obese patients with non-alcoholic fatty liver
   disease: a randomized controlled clinical trial
SO CROATIAN MEDICAL JOURNAL
LA English
DT Article
ID BODY-COMPOSITION; METABOLIC SYNDROME; BLOOD-LIPIDS; VITAMIN-E;
   SUPPLEMENTATION; HUMANS; CLA; ASSOCIATION; OVERWEIGHT; INCREASES
AB Aim To investigate if conjugated linoleic acid supplementation (CLA) affects metabolic factors and oxidative stress in non-alcoholic fatty liver disease (NAFLD).
   Methods The study was a randomized, controlled clinical trial conducted in specialized and subspecialized clinics of Tabriz University of Medical Sciences from January 2014 to March 2015. 38 obese NAFLD patients were randomly allocated into either the intervention group, receiving three 1000 mg softgel of CLA with a weight loss diet and 400 IU vitamin E, or into the control group, receiving only weight loss diet and 400 IU vitamin E for eight weeks. Dietary data and physical activity, as well as anthropometric, body composition, metabolic factors, and oxidative stress were assessed at baseline and at the end of the study.
   Results Weight, body composition, and serum oxidative stress, insulin, and lipid profile significantly improved in both groups, while hemoglobin A1c (HbA1c) levels (P=0.004), total cholesterol to high density lipoprotein ratio (P=0.008), low density lipoprotein to high density lipoprotein ratio (LDL/HDL) (P=0.002), and alanine aminotransferase to aspartate aminotransferase (ALT/AST) ratio (P=0.025) significantly decreased in the intervention group. At the end of the study, fat mass (P=0.001), muscle mass (P=0.023), total body water (P=0.004), HbA1c (P < 0.001), triglycerides (P=0.006), LDL/HDL ratio (P=0.027), and ALT/AST ratio (P=0.046) were significantly better in the CLA group than in the control group.
   Conclusion CLA improved insulin resistance, lipid disturbances, oxidative stress, and liver function in NAFLD. Therefore, it could be considered as an effective complementary treatment in NAFLD.
C1 [Ebrahimi-Mameghani, Mehrangiz; Mahdavi, Reza] Tabriz Univ Med Sci, Sch Nutr, Nutr Res Ctr, Tabriz, Iran.
   [Jamali, Haleh; Abedi, Rana; Kabir-Mamdooh, Bita] Tabriz Univ Med Sci, Sch Nutr, Student Res Comm, Golgasht St,Attar Neishaboori Ave, Tabriz 5166614711, Iran.
   [Kakaei, Farzad] Tabriz Univ Med Sci, Sch Med, Dept Gen Surg, Tabriz, Iran.
C3 Tabriz University of Medical Science; Tabriz University of Medical
   Science; Tabriz University of Medical Science
RP Jamali, H (corresponding author), Tabriz Univ Med Sci, Sch Nutr, Student Res Comm, Golgasht St,Attar Neishaboori Ave, Tabriz 5166614711, Iran.
EM Jamali.Haleh@gmail.com
RI Ebrahimi-Mameghani, Mehrangiz/G-6461-2017; Mahdavi, Reza/C-4773-2017;
   Kakaei, Farzad/H-3647-2018
OI Ebrahimi-Mameghani, Mehrangiz/0000-0002-0311-1289; Mahdavi,
   Reza/0000-0002-5444-2395; Kakaei, Farzad/0000-0003-1632-7393
FU Nutrition Research center, Tabriz University of Medical Sciences, Iran
FX This study was supported by a research grant from Nutrition Research
   center, Tabriz University of Medical Sciences, Iran.
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NR 53
TC 33
Z9 36
U1 0
U2 11
PU MEDICINSKA NAKLADA
PI ZAGREB
PA VLASKA 69, HR-10000 ZAGREB, CROATIA
SN 0353-9504
EI 1332-8166
J9 CROAT MED J
JI Croat. Med. J.
PD AUG
PY 2016
VL 57
IS 4
BP 331
EP 342
DI 10.3325/cmj.2016.57.331
PG 12
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA DY0JN
UT WOS:000384783200004
PM 27586548
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Jump, DB
   Depner, CM
   Tripathy, S
   Lytle, KA
AF Jump, Donald B.
   Depner, Christopher M.
   Tripathy, Sasmita
   Lytle, Kelli A.
TI Potential for Dietary ω-3 Fatty Acids to Prevent Nonalcoholic Fatty
   Liver Disease and Reduce the Risk of Primary Liver Cancer
SO ADVANCES IN NUTRITION
LA English
DT Review
DE fatty liver disease; liver cancer; inflammation; oxidative stress;
   fibrosis; metabolomics; omega-3 PUFAs
ID HEPATIC STEATOSIS; UNITED-STATES; HEPATOCELLULAR-CARCINOMA; METABOLIC
   SYNDROME; OXIDATIVE STRESS; NATURAL-HISTORY; WESTERN DIET; FISH-OIL;
   STEATOHEPATITIS; FIBROSIS
AB Nonalcoholic fatty liver disease (NAFLD) has increased in parallel with central obesity, and its prevalence is anticipated to increase as the obesity epidemic remains unabated. NAFLD is now the most common cause of chronic liver disease in developed countries and is defined as excessive lipid accumulation in the liver, that is, hepatosteatosis. NAFLD ranges in severity from benign fatty liver to nonalcoholic steatohepatitis (NASH), and NASH is characterized by hepatic injury, inflammation, oxidative stress, and fibrosis. NASH can progress to cirrhosis, and cirrhosis is a risk factor for primary hepatocellular carcinoma (HCC). The prevention of NASH will lower the risk of cirrhosis and NASH-associated HCC. Our studies have focused on NASH prevention. We developed a model of NASH by using mice with the LDL cholesterol receptor gene ablated fed the Western diet (WD). The WD induces a NASH phenotype in these mice that is similar to that seen in humans and includes robust induction of hepatic steatosis, inflammation, oxidative stress, and fibrosis. With the use of transcriptomic, lipidomic, and metabolomic approaches, we examined the capacity of 2 dietary omega-3 (n-3) polyunsaturated fatty acids, eicosapentaenoic acid (20:5 omega-3; EPA) and docosahexaenoic acid (22:6 omega-3; DHA), to prevent WD-induced NASH. Dietary DHA was superior to EPA at attenuating WD-induced changes in plasma lipids and hepatic injury and at reversing WD effects on hepatic metabolism, oxidative stress, and fibrosis. The outcome of these studies suggests that DHA may be useful in preventing NASH and reducing the risk of HCC.
C1 [Jump, Donald B.; Depner, Christopher M.; Tripathy, Sasmita; Lytle, Kelli A.] Oregon State Univ, Nutr Program, Sch Biol & Populat Hlth Sci, Linus Pauling Inst, Corvallis, OR 97331 USA.
C3 Oregon State University
RP Jump, DB (corresponding author), Oregon State Univ, Nutr Program, Sch Biol & Populat Hlth Sci, Linus Pauling Inst, Corvallis, OR 97331 USA.
EM donald.jump@oregonstate.edu
FU National Institute of Food and Agriculture [2009-65200-05846]; NIH [DK
   43220, DK094600]
FX Supported by National Institute of Food and Agriculture grant
   2009-65200-05846 and NIH grants DK 43220 and DK094600.
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NR 116
TC 62
Z9 73
U1 3
U2 49
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 2161-8313
EI 2156-5376
J9 ADV NUTR
JI Adv. Nutr.
PD NOV
PY 2015
VL 6
IS 6
BP 694
EP 702
DI 10.3945/an.115.009423
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA CV8ZQ
UT WOS:000364577400007
PM 26567194
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Doronzo, G
   Viretto, M
   Russo, I
   Mattiello, L
   Di Martino, L
   Cavalot, F
   Anfossi, G
   Trovati, M
AF Doronzo, Gabriella
   Viretto, Michela
   Russo, Isabella
   Mattiello, Luigi
   Di Martino, Leonardo
   Cavalot, Franco
   Anfossi, Giovanni
   Trovati, Mariella
TI Nitric oxide activates PI3-K and MAPK signalling pathways in human and
   rat vascular smooth muscle cells: Influence of insulin resistance and
   oxidative stress
SO ATHEROSCLEROSIS
LA English
DT Article
DE Nitric oxide; cGMP; PKG; Vascular smooth muscle cells; PI3-K; MAPK;
   Insulin resistance; Oxidative stress; Zucker rats
ID ENDOTHELIAL GROWTH-FACTOR; PROTEIN-KINASE PATHWAYS; OBESE ZUCKER RAT;
   CYCLIC-GMP; MICROVASCULAR DYSFUNCTION; METABOLIC SYNDROME;
   CARDIOMYOCYTES; INFLAMMATION; APOPTOSIS; PERFUSION
AB Objective: Vascular smooth muscle cells (VSMCs) from the animal model of insulin resistance obese Zucker rats (OZR) show impaired ability of nitric oxide (NO) to increase cGMP and of cGMP to activate its specific kinase PKG, these defects being attributable to oxidative stress. We aimed to investigate the intracellular signalling downstream PKG in human and rat VSMC, and to clarify whether it is modified by insulin resistance and oxidative stress.
   Methods: In aortic VSMC from humans, lean Zucker rats (LZR) and OZR, we measured by Western blots the activation induced by NO and cGMP of signalling molecules of PI3-K and MAPK pathways, with or without PKG inhibition, hydrogen peroxide and antioxidants. We explored the mechanism of the increased oxidative stress in VSMC from OZR by measuring superoxide anion concentrations (luminescence method) with or without inhibition of NADPH oxidase, xanthine oxidase, and mitochondrial electron transport chain complex and by measuring superoxide dismutase (SOD) expression (Western blot) and activity.
   Results: In VSMC from humans and LZR, the NO/cGMP/PKG pathway activates both PI3-K (Akt, mTOR) and MAPK (ERK-1/2, p38MAPK) signalling. This effect is attenuated in VSMC from OZR, in which the greater oxidative stress is mediated by NADPH oxidase and mitochondrial complex and by a reduced synthesis/activity of SOD. Impairment of the NO/cGMP/PKG signalling is reproduced in VSMC from LZR by hydrogen peroxide and reverted in VSMC from OZR by antioxidants.
   Conclusions: In VSMC from an animal model of insulin resistance the NO/cGMP/PKG intracellular signalling is impaired due to an increased oxidative stress. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
C1 [Doronzo, Gabriella; Viretto, Michela; Russo, Isabella; Mattiello, Luigi; Di Martino, Leonardo; Cavalot, Franco; Anfossi, Giovanni; Trovati, Mariella] Univ Turin, Dept Clin & Biol Sci, San Luigi Gonzaga Fac Med, Internal Med & Metab Dis Unit,San Luigi Gonzaga H, I-10043 Turin, Italy.
C3 University of Turin
RP Trovati, M (corresponding author), Univ Turin, Dept Clin & Biol Sci, San Luigi Gonzaga Fac Med, Internal Med & Metab Dis Unit,San Luigi Gonzaga H, I-10043 Turin, Italy.
EM mariella.trovati@unito.it
RI Doronzo, Gabriella/AAC-4953-2022; Russo, Isabella/AAC-5779-2020
OI Cavalot, Franco/0000-0002-2570-0084; TROVATI,
   MARIELLA/0000-0003-4397-8060; Doronzo, Gabriella/0000-0002-3693-8178;
   Russo, Isabella/0000-0002-2921-1763
FU Regione Piemonte
FX This paper has been supported by a grant of Regione Piemonte (Progetti
   di Ricerca Sanitaria Finalizzata 2007) to Mariella Trovati
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NR 30
TC 42
Z9 45
U1 0
U2 16
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0021-9150
J9 ATHEROSCLEROSIS
JI Atherosclerosis
PD MAY
PY 2011
VL 216
IS 1
BP 44
EP 53
DI 10.1016/j.atherosclerosis.2011.01.019
PG 10
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 758YV
UT WOS:000290205800008
PM 21316056
DA 2025-06-11
ER

PT J
AU Lei, K
   Li, YL
   Wang, Y
   Wen, J
   Wu, HZ
   Yu, DY
   Li, WF
AF Lei, Kai
   Li, Ya-li
   Wang, Yang
   Wen, Jing
   Wu, Hong-zhao
   Yu, Dong-you
   Li, Wei-fen
TI Effect of dietary supplementation of Bacillus subtilis B10 on
   biochemical and molecular parameters in the serum and liver of high-fat
   diet-induced obese mice
SO JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
LA English
DT Article
DE Bacillus subtilis; High-fat diet; Oxidative stress; Lipid metabolism
ID INCREASED OXIDATIVE STRESS; LACTIC-ACID BACTERIA; METABOLIC SYNDROME;
   PERFORMANCE; RESISTANCE; METALS; P53
AB While a high-fat diet (HFD) is assumed to be related to fat-mediated oxidative stress decreasing antioxidant enzyme activity, probiotics are believed to have positive effects on the regulation of HFD-induced obesity as well as lipid metabolism, energy homeostasis, and anti-oxidation. Because Bacillus subtilis B10 has beneficial effects on the abnormal lipid metabolism and the oxidative stress in HFD-induced obese mice, ICR mice were randomly assigned into an HFD group and the HFD was supplemented with 0.1% (w/w) Bacillus subtilis B10 (HFD+B10 group). Thereafter, 30-d treatments were run, and then hepatic lipid level and antioxidant status were measured. The expression of genes related to lipid metabolism and oxidative stress in the liver was determined by reverse-transcription quantitative polymerase chain reaction (RT-qPCR). We found that HFD-induced obese mice treated with B10 showed a decrease in weight gain, serum glucose activity as well as hepatic triglyceride (TG), glutamic oxaloacetic transaminase (GOT), and glutamic pyruvic transaminase (GPT) activities. In addition, the gene expressions of antioxidant genes, glutathione reductase (GR), xanthine oxidase (XO), heat-shock protein 90 (Hsp90), and lipid synthesis gene 3 beta-hydroxysteroid-Delta 24 reductase (DHCR24) in the HFD+B10 group were down-regulated, suggesting alleviation of oxidative stress, while the lipolysis gene 3-hydroxy-3-methylglutaryl-CoA synthase 2 (HMGCS2), energy metabolism gene peroxisome proliferator-activated receptor alpha (PPAR alpha) and the gene encoding tumor-suppressor protein p53 were up-regulated. The regulatory and positive effect of dietary supplementation of probiotic B10 suggests that it has a beneficial effect on the homeostasis of the lipid metabolism and on alleviating oxidative stress in HFD-induced obese mice.
C1 [Lei, Kai; Li, Ya-li; Wang, Yang; Wen, Jing; Wu, Hong-zhao; Yu, Dong-you; Li, Wei-fen] Zhejiang Univ, Coll Anim Sci, Inst Feed Sci, Key Lab Mol Anim Nutr,Minist Educ, Hangzhou 310058, Zhejiang, Peoples R China.
C3 Zhejiang University; Ministry of Education - China
RP Li, WF (corresponding author), Zhejiang Univ, Coll Anim Sci, Inst Feed Sci, Key Lab Mol Anim Nutr,Minist Educ, Hangzhou 310058, Zhejiang, Peoples R China.
EM wfli@zju.edu.cn
RI yanping, wu/AAR-4840-2021
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NR 38
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Z9 31
U1 3
U2 41
PU ZHEJIANG UNIV
PI HANGZHOU
PA EDITORIAL BOARD, 20 YUGU RD, HANGZHOU, 310027, PEOPLES R CHINA
SN 1673-1581
EI 1862-1783
J9 J ZHEJIANG UNIV-SC B
JI J. Zhejiang Univ.-SCI. B
PD JUN
PY 2015
VL 16
IS 6
BP 487
EP 495
DI 10.1631/jzus.B1400342
PG 9
WC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
   Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
   Research & Experimental Medicine
GA CL3TI
UT WOS:000356873100008
PM 26055910
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Paganelli, A
   Papaccio, F
   Picardo, M
   Bellei, B
AF Paganelli, Alessia
   Papaccio, Federica
   Picardo, Mauro
   Bellei, Barbara
TI Metabolic anomalies in vitiligo: a new frontier for drug repurposing
   strategies
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Article
DE vitiligo; metabolic syndrome; mitochondrial damage; oxidative stress;
   lipid metabolism; glucose; insulin; PPAR gamma
ID NONMELANOMA SKIN-CANCER; OXIDATIVE STRESS; PPAR-GAMMA;
   SUPEROXIDE-DISMUTASE; AUTOIMMUNE-DISEASES; INCREASED RISK; AUTOPHAGY;
   IDENTIFICATION; SIMVASTATIN; METFORMIN
AB Vitiligo is a chronic autoimmune condition characterized by the destruction of melanocytes, leading to patchy loss of skin depigmentation. Although its precise cause remains unclear, recent evidence suggests that metabolic disturbances, particularly oxidative stress and mitochondrial dysfunction, may play a significant role in the pathogenesis of the disease. Oxidative stress is thought to damage melanocytes and trigger inflammatory responses, culminating in melanocyte immune-mediate destruction. Additionally, patients with vitiligo often exhibit extra-cutaneous metabolic abnormalities such as abnormal glucose metabolism, dyslipidemia, high fasting plasma glucose levels, high blood pressure, out of range C-peptide and low biological antioxidant capacity, suggesting a potential link between metabolic impairment and vitiligo development. This implies that the loss of functional melanocytes mirrors a more general systemic targetable dysfunction. Notably, therapies targeting metabolic pathways, particularly those involving mitochondrial metabolism, such as the peroxisome proliferator-activated nuclear receptor gamma (PPAR gamma) agonists, are currently being investigated as potential treatments for vitiligo. PPAR gamma activation restores mitochondrial membrane potential, mitochondrial DNA copy number and, consequently, ATP production. Moreover, PPAR gamma agonists counteract oxidative stress, reduce inflammation, inhibit apoptosis, and maintain fatty acid metabolism, in addition to the well-known capability to enhance insulin sensitivity. Additionally, increasing evidence of a strong relationship between metabolic alterations and vitiligo pathogenesis suggests a role for other approved anti-diabetic treatments, like metformin and fibrates, in vitiligo treatment. Taken together, these data support the use of approaches alternative to traditional immune-suppressive treatments for the treatment of vitiligo.
C1 [Paganelli, Alessia; Picardo, Mauro] IRCCS, Ist Dermopat Immacolata, Rome, Italy.
   [Papaccio, Federica; Bellei, Barbara] IRCCS, San Gallicano Dermatol Inst, Cutaneous Physiopathol & Integrated Ctr Metabol Re, Rome, Italy.
C3 IRCCS Istituto Dermopatico dell'Immacolata (IDI); IRCCS Istituti
   Fisioterapici Ospitalieri (IFO); IRCCS San Gallicano Dermatological
   Institute (ISG)
RP Picardo, M (corresponding author), IRCCS, Ist Dermopat Immacolata, Rome, Italy.
EM m.picardo@idi.it
RI Papaccio, Federica/M-4127-2018
FU Italian Ministry of Health (MoH) [PNRR-MCNT2-2023-12377707]
FX The author(s) declare that financial support was received for the
   research and/or publication of this article. Italian Ministry of Health
   (MoH), PNRR-MCNT2-2023-12377707.
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NR 146
TC 0
Z9 0
U1 0
U2 0
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD APR 15
PY 2025
VL 16
AR 1546836
DI 10.3389/fphar.2025.1546836
PG 12
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 2AH9R
UT WOS:001477900300001
PM 40303919
DA 2025-06-11
ER

PT J
AU Shahsavani, S
   Fararouei, M
   Soveid, M
   Dehghani, M
   Hoseini, M
AF Shahsavani, Samaneh
   Fararouei, Mohammad
   Soveid, Mahmood
   Dehghani, Mansooreh
   Hoseini, Mohammad
TI Exposure to polycyclic aromatic hydrocarbon-induced oxidative stress in
   Shiraz, Iran: urinary levels, health risk assessment and mediation
   effect of MDA on the risk of metabolic syndromes
SO INTERNATIONAL ARCHIVES OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH
LA English
DT Article
DE Polycyclic aromatic hydrocarbons; Oxidative stress; Risk assessment;
   Blood pressure; Fasting blood sugar; Triglyceride
ID ANTIOXIDANT STATUS; PAH EXPOSURE; ASSOCIATION; OBESITY; CHILDREN;
   ADULTS; 1-HYDROXYPYRENE; INDOOR; DETERMINANTS; 2-NAPHTHOL
AB Purpose Polycyclic Aromatic Hydrocarbons (PAHs) have been identified as carcinogenic and endocrine disrupter compounds that cause Metabolic Syndrome (MetS). Oxidative stress can lead to carcinogenesis and MetS in exposed people. Therefore, the relationship between urinary metabolite of PAH (OH-PAHs) level and the oxidative stress biomarker (Malondialdehyde) effect as the mediator in increasing the risk of MetS due to PAH exposure and risk assessment was investigated in Shiraz, Iran. Methods The first morning void urinary and blood samples were obtained from participants and analyzed. Physical examinations and anthropometric measurements were performed on the day of sampling. An automatic biochemistry analyzer was used to measure the blood cells. The participants' socio-demographic information was gathered using a questionnaire and direct interviews with participants. Results The MetS prevalence was 26%. Malondialdehyde could act as a mediator between exposure to 1-HydroxyPyrene and increase in fast blood sugar, exposure to 2-HydroxyNaphthalene and increase in systolic blood pressure and exposure to 2-HydroxyFluorene and increase in SBP. Hazard quotients varied from 0.009 to 14.92 in women, and from 0.005 to 8.43 for Fluorene and Naphthalene in men, respectively. The Hazard Indexes were greater than one meaning that the non-cancer health risk related to the PAH exposure could be identified in the participants. Conclusion Although oxidative stress has been suggested to lead to MetS and the high HI levels obtained in the current study, future researches are essential to achieve more reliable findings and monitoring the environmental influencing factors in PAH exposure.
C1 [Shahsavani, Samaneh] Shiraz Univ Med Sci, Sch Hlth, Dept Environm Hlth Engn, Student Res Comm, Shiraz, Iran.
   [Fararouei, Mohammad] Shiraz Univ Med Sci, Sch Hlth, Dept Epidemiol, Shiraz, Iran.
   [Soveid, Mahmood] Shiraz Univ Med Sci, Nemazee Hosp, Endocrinol Res Ctr, Shiraz, Iran.
   [Dehghani, Mansooreh; Hoseini, Mohammad] Shiraz Univ Med Sci, Res Ctr Hlth Sci, Sch Hlth, Dept Environm Hlth, Shiraz, Iran.
   [Dehghani, Mansooreh; Hoseini, Mohammad] Shiraz Univ Med Sci, Fac Hlth, POB 111, Shiraz 71645, Iran.
C3 Shiraz University of Medical Science; Shiraz University of Medical
   Science; Shiraz University of Medical Science; Shiraz University of
   Medical Science; Shiraz University of Medical Science
RP Dehghani, M; Hoseini, M (corresponding author), Shiraz Univ Med Sci, Res Ctr Hlth Sci, Sch Hlth, Dept Environm Hlth, Shiraz, Iran.; Dehghani, M; Hoseini, M (corresponding author), Shiraz Univ Med Sci, Fac Hlth, POB 111, Shiraz 71645, Iran.
EM shahsavani.samaneh.1989@gmail.com; fararooei@gmail.com;
   msoveid@sums.ac.ir; mdehghany@sums.ac.ir; mohhoseini@sums.ac.ir
RI Dehghani, Mansooreh/L-9627-2016; Fararouei, mohammad/Q-6931-2018;
   Hoseini, Mohammad/M-6971-2017
OI Fararouei, mohammad/0000-0001-9362-328X; Hoseini,
   Mohammad/0000-0001-5180-3047
FU Shiraz University of Medical Sciences [19157]
FX The research was supported by Research Vice-chancellor of Shiraz
   University of Medical Sciences (Proposal No. 19157).
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NR 81
TC 10
Z9 11
U1 5
U2 34
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0340-0131
EI 1432-1246
J9 INT ARCH OCC ENV HEA
JI Int. Arch. Occup. Environ. Health
PD JUL
PY 2022
VL 95
IS 5
BP 1043
EP 1058
DI 10.1007/s00420-021-01822-8
EA JAN 2022
PG 16
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA 2E5IO
UT WOS:000740167900001
PM 34997324
DA 2025-06-11
ER

PT J
AU Ding, SB
   Yuan, CY
   Si, BJ
   Wang, MR
   Da, SY
   Bai, LX
   Wu, WD
AF Ding, Shibin
   Yuan, Chunyan
   Si, Bingjie
   Wang, Mengruo
   Da, Shuyan
   Bai, Lanxin
   Wu, Weidong
TI Combined effects of ambient particulate matter exposure and a high-fat
   diet on oxidative stress and steatohepatitis in mice
SO PLOS ONE
LA English
DT Article
ID LIVER-DISEASE; NONALCOHOLIC STEATOHEPATITIS; METABOLIC SYNDROME; HEPATIC
   STEATOSIS; INFLAMMATION; RESPONSES; NAFLD; ATHEROSCLEROSIS; CHOLESTEROL;
   PROGRESSION
AB Background
   Chronic exposure to ambient particulate matter with aerodynamic diameters < 2.5 (PM2.5) induces oxidative injury and liver pathogenesis. The present study assessed the effect and mechanism of long-term, real-world airborne particulate matter (PM) exposure on oxidative stress and hepatic steatosis in the context of a standard chow diet (STD) and a high-fat diet (HFD); the study further explored whether a combination of PM exposure and HFD treatment exacerbates the adverse effects in mice.
   Methods
   C57BL/6J mice fed with STD or HFD (41.26% kcal fat) were exposed to PM or filtered air (FA) for 5 months. Lipid metabolism, oxidative stress and liver pathogenesis were evaluated. Real-time PCR and western blotting were performed to determine gene expression and molecular signal transduction in liver.
   Results
   Chronic airborne PM exposure impaired oxidative homeostasis, caused inflammation and induced hepatic steatosis in mice. Further investigation found that exposure to real-world PM increased the expression of hepatic Nrf2 and Nrf2-regulated antioxidant enzyme gene. The increased protein expression of the sterol regulatory element binding protein-1c (SREBP-1c) and fatty acid synthase (FAS) in the liver were also observed in PM-exposed groups. Furthermore, the combination of PM exposure and HFD treatment caused a synergistic effect on the changes of lipid accumulation oxidative stress, inflammation in the mouse liver.
   Conclusions
   Through in vivo study, we reveal that the combination of real-world ambient PM exposure and HFD treatment aggravates hepatic lipid metabolism disorders, inflammation and oxidative stress. PM exposure may accelerate the progression to non-alcoholic steatohepatitis by regulating SREBP-1c/FAS regulatory axis.
C1 [Ding, Shibin; Yuan, Chunyan; Si, Bingjie; Wang, Mengruo; Da, Shuyan; Bai, Lanxin; Wu, Weidong] Xinxiang Med Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Xinxiang, Henan, Peoples R China.
   [Ding, Shibin] Xinxiang Med Univ, Henan Collaborat Innovat Ctr Mol Diag & Lab Med, Xinxiang, Henan, Peoples R China.
C3 Xinxiang Medical University; Xinxiang Medical University
RP Ding, SB (corresponding author), Xinxiang Med Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Xinxiang, Henan, Peoples R China.; Ding, SB (corresponding author), Xinxiang Med Univ, Henan Collaborat Innovat Ctr Mol Diag & Lab Med, Xinxiang, Henan, Peoples R China.
EM dingshibin@163.com
RI Wu, Weidong/LWK-6061-2024
FU Peak Subject Project of Public Health in Xinxiang Medical University
FX This work was supported by Peak Subject Project of Public Health in
   Xinxiang Medical University.
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NR 48
TC 35
Z9 37
U1 1
U2 25
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAR 28
PY 2019
VL 14
IS 3
AR e0214680
DI 10.1371/journal.pone.0214680
PG 18
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA HQ7IR
UT WOS:000462594000108
PM 30921449
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Shirakura, T
   Nomura, J
   Matsui, C
   Kobayashi, T
   Tamura, M
   Masuzaki, H
AF Shirakura, Takashi
   Nomura, Johji
   Matsui, Chieko
   Kobayashi, Tsunefumi
   Tamura, Mizuho
   Masuzaki, Hiroaki
TI Febuxostat, a novel xanthine oxidoreductase inhibitor, improves
   hypertension and endothelial dysfunction in spontaneously hypertensive
   rats
SO NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
LA English
DT Article
DE Xanthine oxidase; Febuxostat; Endothelial dysfunction; Hypertension
ID POLY(ADP-RIBOSE) POLYMERASE ACTIVATION; VASCULAR OXIDATIVE STRESS;
   URIC-ACID; BLOOD-PRESSURE; METABOLIC SYNDROME; OXIDASE ACTIVITY;
   HEART-FAILURE; PART I; ALLOPURINOL; HYPERURICEMIA
AB Xanthine oxidase (XO) is an enzyme responsible for the production of uric acid. XO produces considerable amount of oxidative stress throughout the body. To date, however, its pathophysiologic role in hypertension and endothelial dysfunction still remains controversial. To explore the possible involvement of XO-derived oxidative stress in the pathophysiology of vascular dysfunction, by use of a selective XO inhibitor, febuxostat, we investigated the impact of pharmacological inhibition of XO on hypertension and vascular endothelial dysfunction in spontaneously hypertensive rats (SHRs). Sixteen-week-old SHR and normotensive Wistar-Kyoto (WKY) rats were treated with tap water (control) or water containing febuxostat (3 mg/kg/day) for 6 weeks. Systolic blood pressure (SBP) in febuxostat-treated SHR (220 +/- 3 mmHg) was significantly (P < 0.05) decreased compared with the control SHR (236 +/- 4 mmHg) while SBP in febuxostat-treated WKY was constant. Acetylcholine-induced endothelium-dependent relaxation in aortas from febuxostat-treated SHR was significantly (P < 0.05) improved compared with the control SHR, whereas relaxation in response to sodium nitroprusside was not changed. Vascular XO activity and tissue nitrotyrosine level, a representative indicator of local oxidative stress, were considerably elevated in the control SHR compared with the control WKY, and this increment was abolished by febuxostat. Our results suggest that exaggerated XO activity and resultant increase in oxidative stress in this experimental model contribute to the hypertension and endothelial dysfunction, thereby supporting a notion that pharmacological inhibition of XO is valuable not only for hyperuricemia but also for treating hypertension and related endothelial dysfunction in human clinics.
C1 [Shirakura, Takashi; Nomura, Johji; Matsui, Chieko; Kobayashi, Tsunefumi; Tamura, Mizuho] Teijin Pharma Ltd, Teijin Inst Biomed Res, Pharmaceut Dev Res Labs, 4-3-2 Asahigaoka, Hino, Tokyo 191852, Japan.
   [Masuzaki, Hiroaki] Univ Ryukyus, Grad Sch Med, Dept Internal Med 2, Div Endocrinol Diabet & Metab,Hematol,Rheumatol, Nishihara, Okinawa, Japan.
C3 Teijin Pharma Limited; University of the Ryukyus
RP Shirakura, T (corresponding author), Teijin Pharma Ltd, Teijin Inst Biomed Res, Pharmaceut Dev Res Labs, 4-3-2 Asahigaoka, Hino, Tokyo 191852, Japan.
EM t.shirakura@teijin.co.jp
RI Kobayashi, Tsunefumi/KDO-5495-2024
FU Teijin Pharma Limited
FX This research was supported by Teijin Pharma Limited.
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NR 61
TC 26
Z9 28
U1 0
U2 11
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0028-1298
EI 1432-1912
J9 N-S ARCH PHARMACOL
JI Naunyn-Schmiedebergs Arch. Pharmacol.
PD AUG
PY 2016
VL 389
IS 8
BP 831
EP 838
DI 10.1007/s00210-016-1239-1
PG 8
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA DR1YM
UT WOS:000379700800003
PM 27198514
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Pei, X
   Yao, JJ
   Ran, SM
   Lu, HF
   Yang, S
   Zhang, YN
   Wang, MY
   Shi, HY
   Tan, AH
AF Pei, Xun
   Yao, Junjie
   Ran, Simiao
   Lu, Haifei
   Yang, Shuo
   Zhang, Yini
   Wang, Miyuan
   Shi, Heyuan
   Tan, Aihua
TI Association of serum water-soluble vitamin exposures with the risk of
   metabolic syndrome: results from NHANES 2003-2006
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Article
DE vitamin; metabolic syndrome; weighted quantile sum regression; NHANES;
   co-exposure
ID FOLIC-ACID SUPPLEMENTATION; OXIDATIVE STRESS; ENDOTHELIAL FUNCTION;
   INSULIN-RESISTANCE; FOLATE; DEFICIENCY; INFLAMMATION; LIVER
AB IntroductionExisting evidence suggests an association between certain vitamins and metabolic syndrome (MetS), but few epidemiological studies have focused on the effects of multivitamin co-exposure on MetS. This study aims to investigate the associations of the individual or multiple water-soluble vitamins (i.e., vitamin C (VC), vitamin B9 (VB9), and vitamin B12 (VB12)) with co-exposure to MetS, as well as the dose-response relationships among them. MethodsA cross-sectional study was conducted by employing the National Health and Examination Surveys (NHANESs) 2003-2006. Multivariate-adjusted logistic regression models were used to explore the association between individual serum water-soluble vitamins and the risk of MetS and its components, including waist circumference, triglyceride, high-density lipoprotein, blood pressure, and fasting plasma glucose. Restricted cubic splines were performed to explore the dose-response relationships among them. The quantile g-computation method was adopted to explore the associations of multiple water-soluble vitamins co-exposure with MetS risk and MetS components. ResultsA total of 8983 subjects were involved in the study, of whom 1443 were diagnosed with MetS. The MetS groups had a higher proportion of participants with age >= 60 years, BMI >= 30 kg/m(2), and insufficient physical activity. Compared with the lowest quartile, the third (OR=0.67, 95% CI: 0.48, 0.94) and highest quartiles (OR=0.52, 95%CI: 0.35, 0.76) of VC were associated with lower MetS risk. Restricted cubic splines showed negative dose-response relationships among VC, VB9 and VB12, and MetS. Regarding MetS components, higher VC quartiles were associated with lower waist circumference, triglyceride, blood pressure, and fasting plasma glucose, while higher VC and VB9 quartiles were associated with higher high-density lipoprotein (HDL). Co-exposure to VC, VB9, and VB12 was significantly inversely associated with MetS, with ORs (95% CI) of 0.81 (0.74, 0.89) and 0.84 (0.78, 0.90) in the conditional and marginal structural models, respectively. Furthermore, we found that VC, VB9, and VB12 co-exposure were negatively associated with waist circumference and blood pressure, while VC, VB9, and VB12 co-exposure were positively associated with HDL. ConclusionThis study revealed negative associations of VC, VB9, and VB12 with MetS, while the high water-soluble vitamin co-exposure was associated with a lower MetS risk.
C1 [Pei, Xun] Hubei Univ Chinese Med, Hubei Prov Hosp TCM, Affiliated Hosp, Wuhan, Hubei, Peoples R China.
   [Yao, Junjie] Changchun Univ Chinese Med, Coll Acupuncture & Tuina, Changchun, Jilin, Peoples R China.
   [Ran, Simiao; Yang, Shuo; Tan, Aihua] Affiliated Hubei Univ Chinese Med, HuangGang Hosp Tradit Chinese Med TCM, Dept Gastroenterol, Huanggang, Hubei, Peoples R China.
   [Ran, Simiao; Lu, Haifei; Zhang, Yini; Shi, Heyuan; Tan, Aihua] Hubei Univ Chinese Med, Basic Med Coll, Wuhan, Hubei, Peoples R China.
   [Wang, Miyuan] Univ Chinese Med, Sch Management Beijing, Beijing, Peoples R China.
   [Tan, Aihua] Dongzhimen Hosp Beijing Univ Chinese Med, Postdoctoral Stn Beijing Univ Chinese Med, Beijing, Peoples R China.
C3 Hubei University of Chinese Medicine; Changchun University of Chinese
   Medicine; Hubei University of Chinese Medicine
RP Tan, AH (corresponding author), Affiliated Hubei Univ Chinese Med, HuangGang Hosp Tradit Chinese Med TCM, Dept Gastroenterol, Huanggang, Hubei, Peoples R China.; Shi, HY; Tan, AH (corresponding author), Hubei Univ Chinese Med, Basic Med Coll, Wuhan, Hubei, Peoples R China.; Tan, AH (corresponding author), Dongzhimen Hosp Beijing Univ Chinese Med, Postdoctoral Stn Beijing Univ Chinese Med, Beijing, Peoples R China.
EM Shy79@hbtcm.edu.cn; evan2018@stmail.hbtcm.edu.cn
RI lu, haifei/LEM-1981-2024; yao, junjie/G-9226-2014; Wang,
   Miyuan/JJE-7845-2023
OI Zhang, Yini/0000-0001-7769-0781; Wang, Miyuan/0000-0003-2459-9532; Yao,
   Junjie/0000-0002-7278-9325
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NR 52
TC 10
Z9 10
U1 0
U2 8
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD MAY 12
PY 2023
VL 14
AR 1167317
DI 10.3389/fendo.2023.1167317
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA H1CY4
UT WOS:000993419000001
PM 37251666
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Tokunou, T
   Yoshikawa, T
   Yoshioka, Y
   Ando, SI
AF Tokunou, Tomotake
   Yoshikawa, Tomoko
   Yoshioka, Yasuko
   Ando, Shin-ichi
TI The relationships between intermittent hypoxia and oxidative stress in
   patients with sleep apnea syndrome
SO SLEEP AND BIOLOGICAL RHYTHMS
LA English
DT Article
DE Sleep apnea; Intermittent hypoxia; Oxidative stress; Metabolic syndrome
ID ENDOTHELIAL DYSFUNCTION; CARDIOVASCULAR-DISEASE; PREDICTOR; MORTALITY;
   SMOKING; OBESITY; BURDEN; RISK
AB Intermittent hypoxia in sleep apnea syndrome (SAS) patients increases the oxidative stress and can cause serious cardiovascular diseases such as hypertension or atherosclerotic diseases through endothelial dysfunction. The evaluation of risk caused by oxidative stress, however, is not easy in a clinical setting. Thus, we intended to evaluate the changes in oxidative stress by SAS treatment using a simple method that can be easily used in the clinical testing. We enrolled 42 consecutive newly diagnosed severe SAS patients (30 men). Reactive oxygen species metabolites (d-ROMs) for oxidative stress and biological antioxidant (BAP) in blood samples were estimated using FREE Carrio Duo (R) before and 3 months after continuous positive airway pressure (CPAP) treatment. SAS parameters were obtained by polysomnography before CPAP and endothelial function was measured twice as well. The body mass index and apnea hypopnea index (AHI) were 29.1 +/- 5.3 and 57.9 +/- 19.7/h. The d-ROMs and BAP were 317.4 +/- 71.8 CARR U and 2121.2 +/- 299.6 mu mol/L. Although no significant correlation was found between hypoxia parameters and d-ROMs or BAP before CPAP treatment, we found a significant negative correlation between basal AHI or basal oxygen desaturation index representing intermittent hypoxia and the change in d-ROMs (r = - 0.31, p = 0.046/r = - 0.33, p = 0.03) and between the change in SpO2 < 90% duration (min) representing continuous hypoxia and the change in BAP (r = - 0.35, p = 0.03) after CPAP treatment. The changes in d-ROM and BAP might reflect the different kind of reduction of oxidative stress by CPAP treatment and, thus, can be used as handy indicators of the treatment effect.
C1 [Tokunou, Tomotake] Fukuoka Nursing Coll, Dept Nursing, Div Basic Med Sci & Fundamental Nursing, 2-15-1 Tamura,Sawara Ku, Fukuoka 8140193, Japan.
   [Tokunou, Tomotake] Fukuoka Dent Coll Hosp, Dept Med, Div Cardiol, Fukuoka, Japan.
   [Tokunou, Tomotake] Fukuoka Dent Coll, Oral Med Res Ctr, Fukuoka, Japan.
   [Yoshikawa, Tomoko; Yoshioka, Yasuko; Ando, Shin-ichi] Kyushu Univ Hosp, Sleep Apnea Ctr, Fukuoka, Japan.
   [Yoshioka, Yasuko; Ando, Shin-ichi] Saiseikai Futsukaichi Hosp, Sleep Med Ctr, Chikushino, Japan.
C3 Fukuoka Dental College (FDC); Fukuoka Dental College (FDC); Kyushu
   University
RP Tokunou, T (corresponding author), Fukuoka Nursing Coll, Dept Nursing, Div Basic Med Sci & Fundamental Nursing, 2-15-1 Tamura,Sawara Ku, Fukuoka 8140193, Japan.; Tokunou, T (corresponding author), Fukuoka Dent Coll Hosp, Dept Med, Div Cardiol, Fukuoka, Japan.; Tokunou, T (corresponding author), Fukuoka Dent Coll, Oral Med Res Ctr, Fukuoka, Japan.
EM tokunout@fdcnet.ac.jp
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NR 28
TC 2
Z9 2
U1 0
U2 1
PU SPRINGER JAPAN KK
PI TOKYO
PA SHIROYAMA TRUST TOWER 5F, 4-3-1 TORANOMON, MINATO-KU, TOKYO, 105-6005,
   JAPAN
SN 1446-9235
EI 1479-8425
J9 SLEEP BIOL RHYTHMS
JI Sleep Biol. Rhythms
PD OCT
PY 2024
VL 22
IS 4
BP 499
EP 504
DI 10.1007/s41105-024-00537-w
EA JUN 2024
PG 6
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA P2D2C
UT WOS:001248300100001
PM 39300984
DA 2025-06-11
ER

PT J
AU Park, SH
   Helsley, RN
   Fadhul, T
   Willoughby, JLS
   Noetzli, L
   Tu, HC
   Solheim, MH
   Fujisaka, S
   Pan, H
   Dreyfuss, JM
   Bons, J
   Rose, J
   King, CD
   Schilling, B
   Lusis, AJ
   Pan, CL
   Gupta, M
   Kulkarni, RN
   Fitzgerald, K
   Kern, PA
   Divanovic, S
   Kahn, CR
   Softic, S
AF Park, Se-Hyung
   Helsley, Robert N.
   Fadhul, Taghreed
   Willoughby, Jennifer L. S.
   Noetzli, Leila
   Tu, Ho-Chou
   Solheim, Marie H.
   Fujisaka, Shiho
   Pan, Hui
   Dreyfuss, Jonathan M.
   Bons, Joanna
   Rose, Jacob
   King, Christina D.
   Schilling, Birgit
   Lusis, Aldons J.
   Pan, Calvin
   Gupta, Manoj
   Kulkarni, Rohit N.
   Fitzgerald, Kevin
   Kern, Philip A.
   Divanovic, Senad
   Kahn, C. Ronald
   Softic, Samir
TI Fructose induced KHK-C can increase ER stress independent of its effect
   on lipogenesis to drive liver disease in diet-induced and genetic models
   of NAFLD
SO METABOLISM-CLINICAL AND EXPERIMENTAL
LA English
DT Article
DE Sugar; Fructose; Ketohexokinase; ER stress; NAFLD
ID UNFOLDED PROTEIN RESPONSE; HEPATIC LIPOGENESIS; FATTY; EXPRESSION;
   INSULIN; PHOSPHORYLATION; CONSUMPTION; ATTENUATION; INITIATION;
   DISCOVERY
AB Non-alcoholic fatty liver disease (NAFLD) is a liver manifestation of metabolic syndrome, and is estimated to affect one billion individuals worldwide. An increased intake of a high-fat diet (HFD) and sugar-sweetened beverages are risk-factors for NAFLD development, but how their combined intake promotes progression to a more severe form of liver injury is unknown. Here we show that fructose metabolism via ketohexokinase (KHK) C isoform leads to unresolved endoplasmic reticulum (ER) stress when coupled with a HFD intake. Conversely, a liver-specific knockdown of KHK in mice consuming fructose on a HFD is adequate to improve the NAFLD ac-tivity score and exert a profound effect on the hepatic transcriptome. Overexpression of KHK-C in cultured hepatocytes is sufficient to induce ER stress in fructose free media. Upregulation of KHK-C is also observed in mice with genetically induced obesity or metabolic dysfunction, whereas KHK knockdown in these mice im-proves metabolic function. Additionally, in over 100 inbred strains of male or female mice hepatic KHK expression correlates positively with adiposity, insulin resistance, and liver triglycerides. Similarly, in 241 human subjects and their controls, hepatic Khk expression is upregulated in early, but not late stages of NAFLD. In summary, we describe a novel role of KHK-C in triggering ER stress, which offers a mechanistic understanding of how the combined intake of fructose and a HFD propagates the development of metabolic complications.
C1 [Park, Se-Hyung; Helsley, Robert N.; Fadhul, Taghreed; Softic, Samir] Univ Kentucky, Coll Med, Dept Pediat, Div Pediat Cardiol, Lexington, KY 40536 USA.
   [Willoughby, Jennifer L. S.; Noetzli, Leila; Tu, Ho-Chou; Fitzgerald, Kevin] Alnylam Pharmaceut Inc, Cambridge, MA 02142 USA.
   [Solheim, Marie H.; Fujisaka, Shiho; Kahn, C. Ronald; Softic, Samir] Harvard Med Sch, Joslin Diabet Ctr, Sect Integrat Physiol & Metab, Boston, MA 02215 USA.
   [Solheim, Marie H.] Max Planck Inst Metab Res, Dept Neuronal Control Metab, D-50931 Cologne, Germany.
   [Fujisaka, Shiho] Univ Toyama, Dept Internal Med 1, Toyama 9300194, Japan.
   [Pan, Hui; Dreyfuss, Jonathan M.] Harvard Med Sch, Joslin Diabet Ctr, Bioinformat & Biostat Core, Boston, MA USA.
   [Bons, Joanna; Rose, Jacob; King, Christina D.; Schilling, Birgit] Buck Inst Res Aging, Proteom & Aging Ctr, Novato, CA 94945 USA.
   [Lusis, Aldons J.; Pan, Calvin] Univ Calif Los Angeles, Ctr Hlth Sci A2 237, Dept Human Genet, Dept Med,Div Cardiol, Los Angeles, CA USA.
   [Gupta, Manoj; Kulkarni, Rohit N.] Harvard Med Sch, Harvard Stem Cell Inst, Joslin Diabet Ctr, Sect Islet Cell & Regenerat Biol, Boston, MA 02215 USA.
   [Kern, Philip A.] Univ Kentucky, Coll Med, Dept Med, Div Endocrinol, Lexington, KY 40536 USA.
   [Divanovic, Senad] Univ Cincinnati, Cincinnati Childrens Hosp Med Ctr, Coll Med, Div Immunobiol,Dept Pediat, Cincinnati, OH 45229 USA.
   [Softic, Samir] Univ Kentucky, Coll Med, Dept Pharmacol & Nutr Sci, Lexington, KY 40536 USA.
   [Softic, Samir] Univ Kentucky, 900 South Limestone,Wethington Rm 527, Lexington, KY 40536 USA.
C3 University of Kentucky; Alnylam Pharmaceuticals; Harvard University;
   Harvard Medical School; Harvard University Medical Affiliates; Joslin
   Diabetes Center, Inc.; University of Toyama; Harvard University; Harvard
   Medical School; Harvard University Medical Affiliates; Joslin Diabetes
   Center, Inc.; Buck Institute for Research on Aging; University of
   California System; University of California Los Angeles; Harvard
   University; Harvard Medical School; Harvard University Medical
   Affiliates; Joslin Diabetes Center, Inc.; University of Kentucky;
   Cincinnati Children's Hospital Medical Center; University System of
   Ohio; University of Cincinnati; University of Kentucky; University of
   Kentucky
RP Softic, S (corresponding author), Univ Kentucky, 900 South Limestone,Wethington Rm 527, Lexington, KY 40536 USA.
EM samir.softic@uky.edu
RI Helsley, Robert/AAQ-6032-2021; Softic, Samir/ABD-4612-2020
OI Dreyfuss, Jonathan/0000-0001-7242-3991
FU Alnylam Pharmaceuticals, Inc.; NASPGHAN Foundation Young Investigator
   Award; Pediatric Scientist Development Program Award [HD000850]; COCVD
   Pilot and Feasibility Grant [GM127211, K01DK128022, UL1TR001998, R01
   DK067536, R01DK099222]; Department of Defense [W81XWH2010392]; CCRF
   Endowed Scholar Award [R01 DK117850, R01 HL147883]; NCRR [1S10
   OD028654]; National Heart Lung and Blood Institute [R01HL147883] Funding
   Source: NIH RePORTER; National Institute of Diabetes and Digestive and
   Kidney Diseases [R01DK117850] Funding Source: NIH RePORTER; U.S.
   Department of Defense (DOD) [W81XWH2010392] Funding Source: U.S.
   Department of Defense (DOD)
FX Alnylam Pharmaceuticals, Inc., sponsored the research with grant funding
   and performed KHK knockdown experiment at their institution. JW, LN, HCT
   and KF are employees of Alnylam Pharmaceuticals. Experimental Pathology
   Laboratories, Inc., was hired by Alnylam to objectively grade liver
   histology. This work was also supported by NASPGHAN Foundation Young
   Investigator Award, Pediatric Scientist Development Program Award
   (HD000850) and COCVD Pilot and Feasibility Grant (GM127211) awarded to
   SS; K01DK128022 and UL1TR001998 to RNH; R01 DK067536 to RNK;
   R01DK099222, Department of Defense grant W81XWH2010392, & amp; CCRF
   Endowed Scholar Award to SD and R01 DK117850, and R01 HL147883 grants to
   AJL. We acknowledge the support of instrumentation for the Orbitrap
   Eclipse Tribrid from the NCRR shared instrumentation grant 1S10 OD028654
   to B.S. Rashmi Nemade, Ph.D. of BioMedText, Inc. helped edit the
   manuscript.
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NR 79
TC 18
Z9 20
U1 1
U2 15
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0026-0495
EI 1532-8600
J9 METABOLISM
JI Metab.-Clin. Exp.
PD AUG
PY 2023
VL 145
AR 155591
DI 10.1016/j.metabol.2023.155591
EA JUN 2023
PG 18
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA Q5ZL7
UT WOS:001058302600001
PM 37230214
OA Green Submitted, Bronze, Green Accepted
DA 2025-06-11
ER

PT J
AU Zhang, Q
   Guo, M
   Chen, TY
   Cheng, HZ
   Yang, QW
   Zhao, ZH
   She, R
   Yang, XY
   Xiao, W
   Yang, X
   Li, LJ
AF Zhang, Qian
   Guo, Miao
   Chen, Tianyi
   Cheng, Huizhi
   Yang, Qianwen
   Zhao, Zhuohui
   She, Rong
   Yang, Xiaoyan
   Xiao, Wen
   Yang, Xu
   Li, Lijuan
TI Walking and taking vitamin C alleviates oxidative stress and
   inflammation in overweight students, even in the short-term
SO FRONTIERS IN PUBLIC HEALTH
LA English
DT Article
DE overweight; obesity; oxidative stress; inflammatory cytokine;
   alleviation; walking; vitamin C; intervention; panel study
ID METABOLIC SYNDROME; OBESITY; DYSFUNCTION; MARKERS
AB ObjectiveObese or overweight is a risk factor for some chronic diseases, and oxidative stress and inflammation may be one of the molecular mechanisms leading to the persistence of these chronic diseases. Discovering interventions to alleviate oxidative stress and inflammation in the overweight/obese population, is very important for public health and health education. MethodsA two-week panel intervention study (Run 0-Run 1-Run 2) was conducted. The subjects were 77 overweight/obese undergraduates attending Dali University, with a BMI>24 kg/m(2). The physical indices measured at the end of each run included BMI, waist circumference, serum ROS, TNF-alpha, IL-1 beta and urinary 8-OHdG. Students were allocated to one of four intervention groups: No intervention (control); walking; taking vitamin C; and walking + taking vitamin C. ResultsThe results demonstrated (1) Walking significantly alleviated ROS levels, and this was consistent in Run 1 and Run 2; (2) During Run1, all three intervention modes reduced levels of 8-OHdG, but there was a statistically insignificant increase during Run 2; (3) No alleviating effects of the three intervention modes on TNF-alpha levels during Run 1 and Run 2 were observed; (4) The alleviating effects of the three intervention modes on IL-1 beta levels during Run 1 and Run 2 were clear. ConclusionWalking and taking vitamin C can reduce levels of ROS, 8-OHdG and IL-1 beta, but not TNF-alpha, in overweight/obese participants. These interventions may become potential preventive measures for the overweight against obese-induced oxidative stress and inflammation.
C1 [Zhang, Qian; She, Rong; Yang, Xiaoyan; Yang, Xu; Li, Lijuan] Dali Univ, Inst Nat Antioxidants & Antioxidant Inflammat, Dali, Peoples R China.
   [Zhang, Qian; Cheng, Huizhi; Yang, Qianwen; Li, Lijuan] Dali Univ, Sch Publ Hlth, Dali, Peoples R China.
   [Guo, Miao] Chongqing Univ, Joint Int Res Lab Green Bldg & Built Environm, Minist Educ, Chongqing, Peoples R China.
   [Chen, Tianyi; Zhao, Zhuohui] Fudan Univ, Sch Publ Hlth, Dept Environm Hlth, Shanghai, Peoples R China.
   [Xiao, Wen] Dali Univ, Inst Eastern Himalaya Biodivers Res, Dali, Peoples R China.
   [Yang, Xu] Hubei Univ Sci & Technol, Xianning Med Coll, Xianning, Hubei, Peoples R China.
C3 Dali University; Dali University; Chongqing University; Ministry of
   Education - China; Fudan University; Dali University; Hubei University
   of Science & Technology
RP Yang, X; Li, LJ (corresponding author), Dali Univ, Inst Nat Antioxidants & Antioxidant Inflammat, Dali, Peoples R China.; Li, LJ (corresponding author), Dali Univ, Sch Publ Hlth, Dali, Peoples R China.; Yang, X (corresponding author), Hubei Univ Sci & Technol, Xianning Med Coll, Xianning, Hubei, Peoples R China.
EM lelejuan@dali.edu.cn; yangxu@mail.ccnu.edu.cn
FU Science and technology planning projects of Yunnan Provincial Department
   of Science and Technology; Special Basic Cooperative Research Programs
   of Yunnan Provincial Undergraduate Universities' Association
   [202101BA070001-115]; National Natural Science Foundation of China
   [202001BA070001-065];  [21577045]
FX This research was funded by: (1) Science and technology planning
   projects of Yunnan Provincial Department of Science and Technology
   (202101BA070001-115), (2) Special Basic Cooperative Research Programs of
   Yunnan Provincial Undergraduate Universities' Association
   (202001BA070001-065), and (3) National Natural Science Foundation of
   China (21577045).
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NR 50
TC 3
Z9 3
U1 1
U2 8
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 2296-2565
J9 FRONT PUBLIC HEALTH
JI Front. Public Health
PD OCT 5
PY 2022
VL 10
AR 1024864
DI 10.3389/fpubh.2022.1024864
PG 10
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA 5R6MB
UT WOS:000874621300001
PM 36276369
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Pimenta, M
   Bringhenti, I
   Souza-Mello, V
   Mendes, LKD
   Aguila, MB
   Mandarim-de-Lacerda, CA
AF Pimenta, Marcel
   Bringhenti, Isabele
   Souza-Mello, Vanessa
   dos Santos Mendes, Lara Karise
   Aguila, Marcia B.
   Mandarim-de-Lacerda, Carlos A.
TI High-intensity interval training beneficial effects on body mass, blood
   pressure, and oxidative stress in diet-induced obesity in ovariectomized
   mice
SO LIFE SCIENCES
LA English
DT Article
DE Swimming; High fat diet; Ovariectomy; Oxidative stress; Menopause;
   Molecular biology
ID HIGH-FAT DIET; HUMAN SKELETAL-MUSCLE; INSULIN-RESISTANCE; C57BL/6 MICE;
   CARDIOVASCULAR RISK; METABOLIC SYNDROME; WISTAR RATS; EXERCISE;
   ESTROGEN; MENOPAUSE
AB Aims: To investigate the possible beneficial effect of high-intensity interval training (HIIT) on skeletal muscle oxidative stress, body mass (BM) and systolic blood pressure (SBP) in ovariectomized mice fed or not fed a high-fat diet.
   Main methods: Three-month-old female C57BL/6 mice were bilaterally ovariectomized (OVX group) or submitted to surgical stress without ovariectomy (SHAM group) and separated into standard chow (SHAM-SC; OVX-SC) and high-fat diet (SHAM-HF; OVX-HF) groups. After 13 weeks, an HIIT program (swimming) was carried out for 8 weeks in non-trained (NT) and trained (T) groups.
   Key findings: The significant reduction of uterine mass and the cytological examination of vaginal smears in the OVX group confirmed that ovariectomy was successful. Before the HIIT protocol, the ovariectomized groups showed a greater BM than the SHAM group, irrespective of the diet they received. The HIIT minimized BM gain in animals fed an HF diet and/or ovariectomized. SBP and total cholesterol were increased in the OVX and HF animals compared to their counterparts, and the HIIT efficiently reduced these factors. In the HF and OVX mice, the muscular superoxide dismutase and catalase levels were low while their glutathione peroxidase and glutathione reductase levels were high and the HIIT normalized these parameters.
   Significance: Diet-induced obesity maximizes the deleterious effects of an ovariectomy. The HILT protocol significantly reduced BM, SBP and oxidative stress in the skeletal muscle indicating that HIIT diminishes the cardiovascular and metabolic risk that is inherent to obesity and menopause. (C) 2015 Elsevier Inc. All rights reserved.
C1 [Pimenta, Marcel; Bringhenti, Isabele; Souza-Mello, Vanessa; dos Santos Mendes, Lara Karise; Aguila, Marcia B.; Mandarim-de-Lacerda, Carlos A.] Univ Estado Rio De Janeiro, Biomed Ctr, Lab Morphometry Metab & Cardiovasc Dis, Inst Biol, BR-20551030 Rio De Janeiro, RJ, Brazil.
C3 Universidade do Estado do Rio de Janeiro
RP Mandarim-de-Lacerda, CA (corresponding author), Univ Estado Rio De Janeiro, Biomed Ctr, Lab Morphometry Metab & Cardiovasc Dis, Ave 28 Setembro 87 Fds, BR-20551030 Rio De Janeiro, RJ, Brazil.
EM mandarim@uerj.br
RI Aguila, Marcia/P-2349-2019; Souza-Mello, Vanessa/E-3463-2014;
   Mandarim-de-Lacerda, Carlos/P-2360-2019
OI Barbosa Aguila, Marcia/0000-0003-3994-4589; Mandarim-de-Lacerda,
   Carlos/0000-0003-4134-7978
FU CNPq (Brazilian Council of Science and Technology) [302.154/2011-6];
   FAPERJ (Rio de Janeiro State Foundation for Scientific Research)
   [E-26/201.186/2014]
FX The authors would like to thank Mrs. Aline Penna for her technical
   assistance, Mr. Guilherme Sa for his help in executing the training to
   the CNPq (Brazilian Council of Science and Technology, www.cnpq.br,
   grant # 302.154/2011-6 to CAML) and FAPERJ (Rio de Janeiro State
   Foundation for Scientific Research, www.faperj.br, grant #
   E-26/201.186/2014 to CAML) agencies.
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NR 44
TC 34
Z9 41
U1 1
U2 22
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0024-3205
EI 1879-0631
J9 LIFE SCI
JI Life Sci.
PD OCT 15
PY 2015
VL 139
BP 75
EP 82
DI 10.1016/j.lfs.2015.08.004
PG 8
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA CU7IO
UT WOS:000363710100011
PM 26285177
OA hybrid
DA 2025-06-11
ER

PT J
AU Ebina, S
   Chiba, T
   Ozaki, T
   Kashiwakura, I
AF Ebina, Satoko
   Chiba, Takako
   Ozaki, Takashi
   Kashiwakura, Ikuo
TI Relationship between 8-hydroxydeoxyguanosine levels in
   placental/umbilical cord blood and maternal/neonatal obstetric factors
SO EXPERIMENTAL AND THERAPEUTIC MEDICINE
LA English
DT Article
DE placental/umbilical cord blood; oxidative stress; 8-OHdG; smoking; white
   blood cells
ID OXIDATIVE DNA-DAMAGE; MATERNAL SMOKING; URINARY-EXCRETION;
   NORMAL-PREGNANCY; BIRTH-WEIGHT; SERUM-LEVELS; ORAL CLEFTS; RISK-FACTOR;
   STRESS; MARKER
AB Oxidative stress is associated with the development of various diseases including cancer, arteriosclerosis, diabetes mellitus, hypertension and metabolic syndrome. However, little is known about the involvement of 8-hydroxydeoxyguanosine (8-OHdG) during the perinatal period. At present, few studies have investigated the precise correlations between 8-OHdG levels in cord blood (CB) and the physical conditions of the mother and neonate. To clarify the involvement of 8-OHdG during the perinatal period, the relationships between CB 8-OHdG levels and maternal/neonatal characteristics in vaginal deliveries were determined. The 8-OHdG levels of CB units collected from singleton gestation vaginal deliveries were analyzed. The relationships between 8-OHdG levels and perinatal characteristics were analyzed. The 8-OHdG levels in CB ranged from 0.1 to 1.39 ng/ml (median, 0.37 ng/ml). The relationships between 8-OHdG levels and the perinatal data were analyzed. The 8-OHdG levels detected in the nonsmoking group were significantly lower compared to those in the smoking group. However, no significant correlation was observed between 8-OHdG levels and other maternal/neonatal factors, including umbilical artery acid/base and gas values. Maternal smoking increases the level of the oxidative DNA damage biomarker 8-OHdG in CB. Since oxidative stress may influence the long-term health outcomes of infants after birth, understanding maternal and fetus/neonate stress conditions at delivery may help improve the health of fetuses and infants.
C1 [Chiba, Takako; Kashiwakura, Ikuo] Hirosaki Univ, Grad Sch Hlth Sci, Dept Radiol Life Sci, Hirosaki, Aomori 0368564, Japan.
   [Ebina, Satoko] Hirosaki Univ, Grad Sch Hlth Sci, Dept Disabil & Hlth, Hirosaki, Aomori 0368564, Japan.
   [Ozaki, Takashi] Hirosaki Natl Hosp, Dept Obstet & Gynecol, Hirosaki, Aomori 0368545, Japan.
C3 Hirosaki University; Hirosaki University
RP Kashiwakura, I (corresponding author), Hirosaki Univ, Grad Sch Hlth Sci, Dept Radiol Life Sci, 66-1 Hon Cho, Hirosaki, Aomori 0368564, Japan.
EM ikashi@cc.hirosaki-u.ac.jp
RI Kashiwakura, Ikuo/F-2080-2013
FU Hirosaki University Institutional Research; Grants-in-Aid for Scientific
   Research [24593348] Funding Source: KAKEN
FX This study was supported by a grant from Hirosaki University
   Institutional Research (2011). The study was performed by the research
   group of Ikuo Kashiwakura, who designed the study, performed a series of
   pilot experiments and had overall responsibility. The authors thank
   Ayako Tarakida who assisted with the collection of the CB units from
   normal vaginal deliveries at the Obstetrics and Gynecology Department of
   Hirosaki National Hospital (Hirosaki, Japan) and recorded all perinatal
   data of the study population. All authors contributed equally to the
   preparation of the manuscript.
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NR 37
TC 10
Z9 11
U1 0
U2 11
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1792-0981
EI 1792-1015
J9 EXP THER MED
JI Exp. Ther. Med.
PD SEP
PY 2012
VL 4
IS 3
BP 387
EP 390
DI 10.3892/etm.2012.617
PG 4
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 984RD
UT WOS:000307208100006
PM 23181104
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Alicka, M
   Kornicka-Garbowska, K
   Roecken, M
   Marycz, K
AF Alicka, Michalina
   Kornicka-Garbowska, Katarzyna
   Roecken, Michael
   Marycz, Krzysztof
TI Inhibition of the Low Molecular Weight Protein Tyrosine Phosphatase
   (LMPTP) as a Potential Therapeutic Strategy for Hepatic Progenitor Cells
   Lipotoxicity-Short Communication
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE LMPTP; LMPTP inhibitor; equine hepatic progenitor-like cells;
   chaperone-mediated autophagy; mitophagy; endoplasmic reticulum stress
ID ENDOPLASMIC-RETICULUM STRESS; ACID-PHOSPHATASE; ER STRESS; APOPTOSIS;
   AUTOPHAGY; DIFFERENTIATION; ASSOCIATION; MECHANISMS; CERAMIDE; GLUCOSE
AB Equine metabolic syndrome (EMS) is a cluster of metabolic disorders, such as obesity, hyperinsulinemia, and hyperleptinemia, as well as insulin resistance (IR). In accordance with the theory linking obesity and IR, excessive accumulation of lipids in insulin-sensitive tissues (lipotoxicity), like liver, alters several cellular functions, including insulin signaling. Therefore, the purpose of the study was to isolate equine hepatic progenitor-like cells (HPCs) and assess whether inhibition of low molecular weight protein tyrosine phosphatase (LMPTP) affects the expression of genes involved in macroautophagy, chaperone-mediated autophagy (CMA), endoplasmic reticulum stress, and mitochondrial dynamics in a palmitate-induced IR model. We demonstrated that LMPTP inhibition significantly enhanced expression of heat shock cognate 70 kDa protein (HSC70), lysosome-associated membrane protein 2 (LAMP2), and parkin (PRKN), all master regulators of selective autophagy. We also observed downregulation of C/EBP homologous protein (CHOP), activating transcription factor 6 (ATF6) and binding immunoglobulin protein encoded by the HSPA gene. Moreover, LMPTP inhibition increased alternative splicing of X-box binding protein 1 (XBP1), suggesting high endonuclease activity of inositol-requiring enzyme 1 alpha (IRE1 alpha). Taken together, our data provide convincing evidence that LMPTP inhibition reverses palmitate-induced insulin resistance and lipotoxicity. In conclusion, this study highlights the role of LMPTP in the regulation of CMA, mitophagy, and ER stress, and provides a new in vitro model for studying HPC lipotoxicity in pre-clinical research.
C1 [Alicka, Michalina; Kornicka-Garbowska, Katarzyna; Marycz, Krzysztof] Wroclaw Univ Environm & Life Sci, Dept Expt Biol, Norwida 27B, PL-50375 Wroclaw, Poland.
   [Kornicka-Garbowska, Katarzyna; Roecken, Michael; Marycz, Krzysztof] Int Inst Translat Med, Jesionowa 11, PL-55114 Malin, Wisznia Mala, Poland.
   [Marycz, Krzysztof] Justus Liebig Univ, Equine Clin Equine Surg, Fac Vet Med, D-35392 Giessen, Germany.
C3 Wroclaw University of Environmental & Life Sciences; Justus Liebig
   University Giessen
RP Marycz, K (corresponding author), Wroclaw Univ Environm & Life Sci, Dept Expt Biol, Norwida 27B, PL-50375 Wroclaw, Poland.; Marycz, K (corresponding author), Int Inst Translat Med, Jesionowa 11, PL-55114 Malin, Wisznia Mala, Poland.; Marycz, K (corresponding author), Justus Liebig Univ, Equine Clin Equine Surg, Fac Vet Med, D-35392 Giessen, Germany.
EM michalina.alicka@upwr.edu.pl; kornicka.katarzyna@gmail.com;
   Michael.Roecken@vetmed.uni-giessen.de; krzysztofmarycz@interia.pl
RI Alicka, Michalina/AGZ-1134-2022
OI Marycz, Krzysztof/0000-0003-3676-796X; Alicka,
   Michalina/0000-0002-6717-9864
FU Narodowe Centrum Nauki [2018/29/B/NZ7/02662]
FX Narodowe Centrum Nauki: 2018/29/B/NZ7/02662.
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NR 49
TC 7
Z9 8
U1 0
U2 6
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD DEC
PY 2019
VL 20
IS 23
AR 5873
DI 10.3390/ijms20235873
PG 13
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA JY5AR
UT WOS:000504428300055
PM 31771123
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Favero, G
   Golic, I
   Arnaboldi, F
   Cappella, A
   Korac, A
   Monsalve, M
   Stacchiotti, A
   Rezzani, R
   Pisani, DF
AF Favero, Gaia
   Golic, Igor
   Arnaboldi, Francesca
   Cappella, Annalisa
   Korac, Aleksandra
   Monsalve, Maria
   Stacchiotti, Alessandra
   Rezzani, Rita
   Pisani, Didier F.
TI Cardiometabolic Changes in Sirtuin1-Heterozygous Mice on High-Fat Diet
   and Melatonin Supplementation
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE sirtuin1; melatonin; heart; epididymal adipose tissue; interscapular
   brown adipose tissue; mitochondria; endoplasmic reticulum stress;
   obesity
ID ADIPOSE-TISSUE; MITOCHONDRIAL DYNAMICS; CARDIOVASCULAR-DISEASE; CARDIAC
   DYSFUNCTION; MEDIATED APOPTOSIS; OXIDATIVE STRESS; ER STRESS; SIRT1;
   HEART; OBESITY
AB A hypercaloric fatty diet predisposes an individual to metabolic syndrome and cardiovascular complications. Sirtuin1 (SIRT1) belongs to the class III histone deacetylase family and sustains anabolism, mitochondrial biogenesis, and fat distribution. Epididymal white adipose tissue (eWAT) is involved in inflammation, whilst interscapular brown adipose tissue (iBAT) drives metabolism in obese rodents. Melatonin, a pineal indoleamine, acting as a SIRT1 modulator, may alleviate cardiometabolic damage. In the present study, we morphologically characterized the heart, eWAT, and iBAT in male heterozygous SIRT1+/- mice (HET mice) on a high-fat diet (60%E lard) versus a standard rodent diet (8.5% E fat) and drinking melatonin (10 mg/kg) for 16 weeks. Wild-type (WT) male C57Bl6/J mice were similarly fed for comparison. Cardiomyocyte fibrosis and endoplasmic reticulum (ER) stress response worsened in HET mice on a high-fat diet vs. other groups. Lipid peroxidation, ER, and mitochondrial stress were assessed by 4 hydroxy-2-nonenal (4HNE), glucose-regulated protein78 (GRP78), CCAA/enhancer-binding protein homologous protein (CHOP), heat shock protein 60 (HSP60), and mitofusin2 immunostainings. Ultrastructural analysis indicated the prevalence of atypical inter-myofibrillar mitochondria with short, misaligned cristae in HET mice on a lard diet despite melatonin supplementation. Abnormal eWAT adipocytes, crown-like inflammatory structures, tumor necrosis factor alpha (TNF alpha), and iBAT whitening characterized HET mice on a hypercaloric fatty diet and were maintained after melatonin supply. All these data suggest that melatonin's mechanism of action is strictly linked to full SIRT1 expression, which is required for the exhibition of effective antioxidant and anti-inflammatory properties.
C1 [Favero, Gaia; Rezzani, Rita] Univ Brescia, Dept Clin & Expt Sci, Anat & Physiopathol Div, Viale Europa 11, I-25123 Brescia, Italy.
   [Favero, Gaia; Rezzani, Rita] Univ Brescia, Interdipartimental Univ Ctr Res Adapt & Regenerat, I-25123 Brescia, Italy.
   [Golic, Igor; Korac, Aleksandra] Univ Belgrade, Fac Biol, Ctr Electron Microscopy, Studentski Trg 16, Belgrade 11000, Serbia.
   [Arnaboldi, Francesca; Cappella, Annalisa; Stacchiotti, Alessandra] Univ Milan, Dept Biomed Sci Hlth, Via Mangiagalli 31, I-20133 Milan, Italy.
   [Cappella, Annalisa; Stacchiotti, Alessandra] IRCCS Policlin San Donato, UO Lab Morfol Umana Applicata, I-20097 Milan, Italy.
   [Monsalve, Maria] Inst Invest Biomed Alberto Sols CSIC UAM, Madrid 28029, Spain.
   [Rezzani, Rita] Italian Soc Study Orofacial Pain, Soc Italiana Studio Dolore Orofacciale SISDO, I-25123 Brescia, Italy.
C3 University of Brescia; University of Brescia; University of Belgrade;
   University of Milan; IRCCS Policlinico San Donato; Consejo Superior de
   Investigaciones Cientificas (CSIC); CSIC - Instituto de Investigaciones
   Biomedicas Alberto Sols (IIBM)
RP Stacchiotti, A (corresponding author), Univ Milan, Dept Biomed Sci Hlth, Via Mangiagalli 31, I-20133 Milan, Italy.; Stacchiotti, A (corresponding author), IRCCS Policlin San Donato, UO Lab Morfol Umana Applicata, I-20097 Milan, Italy.
EM gaia.favero@unibs.it; igor.golic@bio.bg.ac.rs;
   francesca.arnaboldi1@unimi.it; annalisa.cappella@unimi.it;
   aleksandra.korac@bio.bg.ac.rs; mpmonsalve@iib.uam.es;
   alessandra.stacchiotti@unimi.it; rita.rezzani@unibs.it
RI Arnaboldi, Francesca/HNB-7257-2023; Stacchiotti,
   Alessandra/AAA-2193-2019; Golic, Igor/B-4492-2009; Pisani,
   Didier/AAC-2997-2019; Monsalve, Maria/K-4416-2014; Cappella,
   Annalisa/V-5586-2017
OI stacchiotti, alessandra/0000-0002-6767-6617; Rezzani,
   Rita/0000-0002-7515-5846; Monsalve, Maria/0000-0003-2796-1453;
   Arnaboldi, Francesca/0000-0003-2041-9928; Favero,
   Gaia/0000-0001-6895-7106; Cappella, Annalisa/0000-0002-4527-4203
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NR 88
TC 2
Z9 2
U1 0
U2 1
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD JAN
PY 2024
VL 25
IS 2
AR 860
DI 10.3390/ijms25020860
PG 19
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA GD8B9
UT WOS:001150808900001
PM 38255934
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Silhavy, J
   Zídek, V
   Mlejnek, P
   Landa, V
   Simáková, M
   Strnad, H
   Oliyarnyk, O
   Skop, V
   Kazdová, L
   Kurtz, T
   Pravenec, M
AF Silhavy, Jan
   Zidek, Vaclav
   Mlejnek, Petr
   Landa, Vladimir
   Simakova, Miroslava
   Strnad, Hynek
   Oliyarnyk, Olena
   Skop, Vojtech
   Kazdova, Ludmila
   Kurtz, Theodore
   Pravenec, Michal
TI Fumaric Acid Esters Can Block Pro-Inflammatory Actions of Human CRP and
   Ameliorate Metabolic Disturbances in Transgenic Spontaneously
   Hypertensive Rats
SO PLOS ONE
LA English
DT Article
ID C-REACTIVE PROTEIN; FALSE DISCOVERY RATE; DIMETHYL FUMARATE; OXIDATIVE
   STRESS; NICOTINIC-ACID; GPR109A; INNATE
AB Inflammation and oxidative stress have been implicated in the pathogenesis of metabolic disturbances. Esters of fumaric acid, mainly dimethyl fumarate, exhibit immunomodulatory, anti-inflammatory, and anti-oxidative effects. In the current study, we tested the hypothesis that fumaric acid ester (FAE) treatment of an animal model of inflammation and metabolic syndrome, the spontaneously hypertensive rat transgenically expressing human C-reactive protein (SHR-CRP), will ameliorate inflammation, oxidative stress, and metabolic disturbances. We studied the effects of FAE treatment by administering Fumaderm, 10 mg/kg body weight for 4 weeks, to male SHR-CRP. Untreated male SHR-CRP rats were used as controls. All rats were fed a high sucrose diet. Compared to untreated controls, rats treated with FAE showed significantly lower levels of endogenous CRP but not transgenic human CRP, and amelioration of inflammation (reduced levels of serum IL6 and TNF alpha) and oxidative stress (reduced levels of lipoperoxidation products in liver, heart, kidney, and plasma). FAE treatment was also associated with lower visceral fat weight and less ectopic fat accumulation in liver and muscle, greater levels of lipolysis, and greater incorporation of glucose into adipose tissue lipids. Analysis of gene expression profiles in the liver with Affymetrix arrays revealed that FAE treatment was associated with differential expression of genes in pathways that involve the regulation of inflammation and oxidative stress. These findings suggest potentially important antiinflammatory, anti-oxidative, and metabolic effects of FAE in a model of inflammation and metabolic disturbances induced by human CRP.
C1 [Silhavy, Jan; Zidek, Vaclav; Mlejnek, Petr; Landa, Vladimir; Simakova, Miroslava; Pravenec, Michal] Acad Sci Czech Republ, Inst Physiol, Prague, Czech Republic.
   [Strnad, Hynek] Acad Sci Czech Republ, Inst Mol Genet, Prague, Czech Republic.
   [Oliyarnyk, Olena; Skop, Vojtech; Kazdova, Ludmila] Inst Clin & Expt Med, Ctr Med Expt, Prague, Czech Republic.
   [Kurtz, Theodore] Univ Calif San Francisco, San Francisco, CA 94143 USA.
C3 Czech Academy of Sciences; Institute of Physiology of the Czech Academy
   of Sciences; Czech Academy of Sciences; Institute of Molecular Genetics
   of the Czech Academy of Sciences; Institute for Clinical & Experimental
   Medicine (IKEM); University of California System; University of
   California San Francisco
RP Pravenec, M (corresponding author), Acad Sci Czech Republ, Inst Physiol, Prague, Czech Republic.
EM pravenec@biomed.cas.cz
RI Zidek, Vaclav/C-6685-2012; Simakova, Miroslava/R-5367-2019; Strnad,
   Hynek/B-7361-2008; Oliyarnyk, Olena/Q-6380-2019; Landa,
   Vladimir/B-8908-2012; Silhavy, Jan/B-5292-2014; Mlejnek,
   Petr/C-2305-2012; Pravenec, Michal/B-1666-2012; Skop,
   Vojtech/LBI-2231-2024
OI Oliyarnyk, Olena/0000-0002-4912-6187; Simakova,
   Miroslava/0000-0003-1468-5832; Mlejnek, Petr/0000-0002-4218-8983;
   Pravenec, Michal/0000-0001-9197-5871; Skop, Vojtech/0000-0002-4685-4429
FU Ministry of Health of the Czech Republic [NT/14325]; MH CZ - DRO
   ("Institute for Clinical and Experimental Medicine - IKEM") [IN
   0002301]; Ministry Education, Youth and Sports of the Czech Republic
   [LH12061, LL1204]
FX This study was supported by grant NT/14325 from the Ministry of Health
   of the Czech Republic, grant MH CZ - DRO ("Institute for Clinical and
   Experimental Medicine - IKEM, IN 0002301") and grants LH12061 to VL and
   LL1204 (within the ERC CZ program) from the Ministry Education, Youth
   and Sports of the Czech Republic to MP. The funders had no role in study
   design, data collection and analysis, decision to publish, or
   preparation of the manuscript.
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NR 32
TC 24
Z9 30
U1 1
U2 18
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JUL 10
PY 2014
VL 9
IS 7
AR e101906
DI 10.1371/journal.pone.0101906
PG 9
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA AK9RG
UT WOS:000338763800051
PM 25010431
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Yan, YX
   Xiao, HB
   Zhang, J
   Wang, S
   Dong, J
   Wu, LJ
AF Yan, Yu-Xiang
   Xiao, Huan-Bo
   Zhang, Jie
   Wang, Shuo
   Dong, Jing
   Wu, Li-Juan
TI Pri-miR-144 rs9279 is associated with type 2 diabetes and regulation of
   stress response
SO JOURNAL OF CELLULAR PHYSIOLOGY
LA English
DT Article
DE microRNA; polymorphism; stress; type 2 diabetes
ID INSULIN-RESISTANCE; METABOLIC SYNDROME; GENETIC-VARIATION; EXPRESSION;
   MICRORNAS; MELLITUS; MIR-144; CANCER; RISK
AB Single-nucleotide polymorphisms (SNPs) of microRNAs (miRNAs) may alter miRNA expression, binding affinity, and/or messenger RNA expression levels of the target genes, thus leading to disease susceptibility. This study explored the association between SNPs in neuroendocrine stress response-related miRNAs and type 2 diabetes (T2D). In the screening stage, the association between six candidate SNPs of miRNAs and T2D was analyzed in a case-control study including 504 T2D cases and 494 healthy controls. Homozygous GG genotype of pri-miR-144 rs9279 showed significant association with increased risk of T2D compared with homozygous TT genotype (adjusted odds ratio [OR] = 1.62, 95% confidence interval [CI]: 1.07-2.45;p = .023) and the combined TT/TG genotype (adjusted OR = 1.59, 95% CI: 1.08-2.36;p = .020). In the validation stage, the association was further validated in a second independent set of subjects. The GG genotype showed consistent directions and effect sizes that were identified in previous additive and recessive models. The expression levels of miRNAs were further compared between different genotypes in the 179 newly diagnosed cases and 183 frequency-matched healthy controls. As a result, the GG genotype carriers had significantly upregulated expression of plasma miR-144 and cortisol, as compared to individuals with TT and TG genotypes, respectively, in total subjects and subgroups (p < .05). Eventually, NR3C1 was proved to be a stress-related target gene of miR-144, indicating that pri-miR-144 rs9279 may contribute to the development of T2D by altering regulation of stress response.
C1 [Yan, Yu-Xiang; Zhang, Jie; Wang, Shuo; Wu, Li-Juan] Capital Med Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, 10 Xitoutiao, Beijing 100069, Peoples R China.
   [Yan, Yu-Xiang; Zhang, Jie; Wang, Shuo; Wu, Li-Juan] Municipal Key Lab Clin Epidmiol, Beijing, Peoples R China.
   [Xiao, Huan-Bo] Capital Med Univ, Yanjing Med Coll, Dept Prevent Med, Beijing, Peoples R China.
   [Dong, Jing] Capital Med Univ, Xuanwu Hosp, Hlth Management Ctr, Beijing, Peoples R China.
C3 Capital Medical University; Capital Medical University; Capital Medical
   University
RP Yan, YX; Wu, LJ (corresponding author), Capital Med Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, 10 Xitoutiao, Beijing 100069, Peoples R China.
EM yanyxepi@ccmu.edu.cn; wujuan811017@163.com
RI wang, shuo/MIT-1662-2025; Dong, Jing/KDM-6171-2024
OI Yan, Yu-Xiang/0000-0002-6021-1905
FU National Natural Science Foundation of China [81573214, 81773511];
   Beijing Municipal Natural Science Foundation [7162020]
FX National Natural Science Foundation of China, Grant/Award Numbers:
   81573214, 81773511; Beijing Municipal Natural Science Foundation,
   Grant/Award Number: 7162020
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NR 32
TC 8
Z9 8
U1 1
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0021-9541
EI 1097-4652
J9 J CELL PHYSIOL
JI J. Cell. Physiol.
PD JAN
PY 2021
VL 236
IS 1
BP 561
EP 569
DI 10.1002/jcp.29883
EA JUN 2020
PG 9
WC Cell Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Physiology
GA OT9OU
UT WOS:000541027200001
PM 32557658
DA 2025-06-11
ER

PT J
AU Cakir, OO
   Culha, MG
   Arisan, S
   Arisan, ED
   Altin, M
   Ward, S
   Zengi, O
   Ergenekon, E
AF Cakir, Omer Onur
   Culha, Mehmet Gokhan
   Arisan, Serdar
   Arisan, Elif Damla
   Altin, Murat
   Ward, Sam
   Zengi, Oguzhan
   Ergenekon, Erbil
TI Serum Antioxidant Enzyme Levels are Decreased in Patients with Urinary
   Calcium Oxalate Stones
SO UROLOGY JOURNAL
LA English
DT Article
DE antioxidants; calcium oxalate; oxidative stress; reactive oxygen
   species; urinary stone disease
ID INDUCED OXIDATIVE STRESS; KIDNEY-STONES; METABOLIC SYNDROME; POMEGRANATE
   JUICE; RISK-FACTORS; NEPHROLITHIASIS; HYPERTENSION; ASSOCIATION;
   POPULATION; OBESITY
AB Purpose: To compare the serum antioxidant enzyme levels between patients with urinary stone disease and healthy volunteers to determine the effect of cellular oxidative stress on urinary calcium oxalate stones formation.
   Materials & Methods: A total of 51 patients with proven urinary calcium oxalate stones (female 35.3%, mean age: 49.3 years) and 37 healthy subjects (female 45.9%, mean age: 44.1 years) were included. The serum levels of antioxidant catalase, glutathione peroxidase, superoxide dismutase and lipid peroxidation were measured in serum samples taken from the peripheral venous circulation.
   Results: Mean serum catalase level of patient group was insignificantly higher than healthy subjects (7.54 mmol-H2O/mg/sec versus 6.16 mmolH2O2/mg/sec, respectively; P = .06) whereas mean superoxide dismutase level (1.56 U/ml versus 3.86 U/ml, P = .047), glutathione peroxidase level (6.70 U/ml versus 8.19 U/ml, P = .022) and lipid peroxidation level (2.35 nmol/ml versus 3.31 nmol/ml, P = .034) of patient group were significantly lower than healthy subjects. Patients with family history of urinary stone disease had significantly lower mean serum levels of catalase (P = .037), superoxide dismutase (P = .047) and glutathione peroxidase (P = .01), compared with patients without family history.
   Conclusion: The findings of this study provide evidence regarding the role of oxidative stress in the development of urinary calcium oxalate stones. Future clinical trials are necessary to elucidate the actual mechanisms of the calcium oxalate stone formation in the environment with increased oxidative stress.
C1 [Cakir, Omer Onur] Bagcilar Training & Res Hosp, Dept Urol, Istanbul, Turkey.
   [Culha, Mehmet Gokhan] Samatya Training & Res Hosp, Dept Urol, Istanbul, Turkey.
   [Arisan, Serdar; Ergenekon, Erbil] Sisli Etfal Training & Res Hosp, Dept Urol, Istanbul, Turkey.
   [Arisan, Elif Damla] Kultur Univ, Dept Mol Biol & Genet, Istanbul, Turkey.
   [Altin, Murat] Med Pk Gazi Osman Pasha Hosp, Dept Psychiat, Istanbul, Turkey.
   [Ward, Sam] Klin Sint Jan Hosp, Dept Urol, Brussels, Belgium.
   [Zengi, Oguzhan] Bagcilar Training & Res Hosp, Dept Biochem, Istanbul, Turkey.
C3 Istanbul Bagcilar Training & Research Hospital; Istanbul Training &
   Research Hospital; Istanbul Sisli Hamidiye Etfal Training & Research
   Hospital; Istanbul Bagcilar Training & Research Hospital
RP Cakir, OO (corresponding author), Merkez Mah Mimar Sinan Cad 6 Sokak, TR-34200 Istanbul, Turkey.
EM omeronurcakir@gmail.com
RI Arisan, Elif/W-8682-2019; Cakir, Omer Onur/D-7375-2017; ,
   gokhanculha/AAL-8393-2020; zengi, oguzhan/AAH-3135-2019; ward,
   sam/Y-2880-2019
OI ward, sam/0000-0003-0806-0510; Cakir, Omer Onur/0000-0001-7499-7227;
   ARISAN, SERDAR/0000-0002-1130-1701; Arisan, Elif
   Damla/0000-0002-4844-6381
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NR 22
TC 1
Z9 1
U1 0
U2 3
PU UROL & NEPHROL RES CTR-UNRC
PI TEHRAN
PA NO 44, 9TH BOUSTAN ST, PASADARAN AVE, TEHRAN, 00000, IRAN
SN 1735-1308
EI 1735-546X
J9 UROL J
JI Urol. J.
PD JUL-AUG
PY 2017
VL 14
IS 4
BP 4015
EP 4019
PG 5
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA FK8YF
UT WOS:000413796900002
PM 28670668
DA 2025-06-11
ER

PT J
AU Kozuka, C
   Yabiku, K
   Takayama, C
   Matsushita, M
   Shimabukuro, M
   Masuzaki, H
AF Kozuka, Chisayo
   Yabiku, Kouichi
   Takayama, Chitoshi
   Matsushita, Masayuki
   Shimabukuro, Michio
   Masuzaki, Hiroaki
TI Natural food science based novel approach toward prevention and
   treatment of obesity and type 2 diabetes: Recent studies on brown rice
   and γ-oryzanol
SO OBESITY RESEARCH & CLINICAL PRACTICE
LA English
DT Review
DE Brown rice; gamma-Oryzanol; Endoplasmic reticulum stress; Food
   preference; Insulin secretion
ID ENDOPLASMIC-RETICULUM STRESS; HIGH-FAT DIET; FERULIC ACID; ANTIOXIDANT
   ACTIVITY; METABOLIC SYNDROME; LIPID-METABOLISM; ER STRESS; BETA-CELL;
   BRAN OIL; KAPPA-B
AB The prevalences of obesity and type 2 diabetes mellitus are dramatically increasing, and there is a strong need for more effective and safer therapies. However, some of drugs show limited efficacy and considerable adverse effects. Furthermore, artificial energy-dense foods and non-caloric foods may promote overeating and weight gain. In this context, a natural food-based approach may represent a valuable means of tackling the obesity-diabetes syndrome. Although recent studies have shown that brown rice improves glucose intolerance and prevents obesity and type 2 diabetes in humans, the underlying molecular mechanisms remain unclear. We found that one of the major components of brown rice, gamma-oryzanol (Orz), plays an important role in the metabolically beneficial effects of brown rice. Orz acts as a chemical chaperone and decreases high fat diet (HFD)-induced endoplasmic reticulum (ER) stress in the hypothalamus, thereby leading to a significant shift in preference from fatty to healthy foods. Orz also decreases HFD-induced ER stress in pancreatic beta-cells and improves beta-cell function. Notably, Orz directly acts on pancreatic islets and enhances glucose-stimulated insulin secretion (GSIS). This evidence highlights food preference as a promising therapeutic target in obesity-diabetes syndrome and suggests that brown rice and Orz may have potential for the treatment of obesity and type 2 diabetes in humans. (C) 2013 Asian Oceanian Association for the Study of Obesity. Published by Elsevier Ltd. All rights reserved.
C1 [Kozuka, Chisayo; Yabiku, Kouichi; Masuzaki, Hiroaki] Univ Ryukyus, Grad Sch Med, Dept Internal Med 2, Div Endocrinol Diabet & Metab, Ryukyus, Okinawa, Japan.
   [Takayama, Chitoshi] Univ Ryukyus, Grad Sch Med, Dept Mol Anat, Ryukyus, Okinawa, Japan.
   [Matsushita, Masayuki] Univ Ryukyus, Grad Sch Med, Dept Mol & Cellular Physiol, Ryukyus, Okinawa, Japan.
   [Shimabukuro, Michio] Univ Tokushima, Grad Sch Hlth Biosci, Dept Cardiodiabet Med, Tokushima, Japan.
C3 University of the Ryukyus; University of the Ryukyus; University of the
   Ryukyus; Tokushima University
RP Masuzaki, H (corresponding author), Univ Ryukyus, Grad Sch Med, Dept Internal Med 2, Div Endocrinol Diabet & Metab, Ryukyus, Okinawa, Japan.
EM hiroaki@med.u-ryukyu.ac.jp
RI Kozuka, Chisayo/KEZ-9801-2024
OI Kozuka, Chisayo/0000-0002-9567-8361
FU Ministry of Education, Culture, Sports, Science, and Technology of Japan
   (MEXT) [24591338, 24591014, 24591063]; Takeda Science Foundation
   (Specified Research Grant); Ichiro Kanehara Foundation; Metabolic
   Syndrome Foundation; project "Establishing a research hub toward the
   development of an intellectual cluster in Okinawa Prefecture, Japan'';
   Grants-in-Aid for Scientific Research [24591014, 24591063, 24591338]
   Funding Source: KAKEN
FX This work was supported in part by Grants-in-Aid from the Ministry of
   Education, Culture, Sports, Science, and Technology of Japan (MEXT;
   KAKENHI Grant Numbers 24591338, 24591014, 24591063), the Takeda Science
   Foundation (Specified Research Grant), the Ichiro Kanehara Foundation,
   Metabolic Syndrome Foundation, and the project "Establishing a research
   hub toward the development of an intellectual cluster in Okinawa
   Prefecture, Japan.''
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NR 65
TC 68
Z9 70
U1 4
U2 75
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1871-403X
EI 1878-0318
J9 OBES RES CLIN PRACT
JI Obes. Res. Clin. Pract.
PD MAY-JUN
PY 2013
VL 7
IS 3
BP E165
EP E172
DI 10.1016/j.orcp.2013.02.003
PG 8
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 146SO
UT WOS:000319111400001
PM 23697584
DA 2025-06-11
ER

PT J
AU Ladwig, KH
   Marten-Mittag, B
   Lacruz, ME
   Henningsen, P
   Creed, F
AF Ladwig, Karl Heinz
   Marten-Mittag, Birgitt
   Lacruz, Maria Elena
   Henningsen, Peter
   Creed, Francis
CA MONICA KORA Investigators
TI Screening for multiple somatic complaints in a population-based survey:
   Does excessive symptom reporting capture the concept of somatic symptom
   disorders?
SO JOURNAL OF PSYCHOSOMATIC RESEARCH
LA English
DT Article
DE Somatic symptom disorders; Excessive symptom reporting; Medical
   utilization; Mortality
AB Objective: Excessive symptom reporting (ESR) has gained a revived attention in the conceptualization of somatic symptom disorders We aimed to explore whether ESR captures the concept of somatic symptom disorders regardless of the patient's disease status or the degree of symptom burden Methods: In three independent cross-sectional population-based samples of the MONICA/KORA Study in 1985, 1990, and 1995, somatic symptom reporting and an array of somatic and mental health features were assessed in 11,895 eligible participants After a mean 12-year follow-up, the vital status was assessed at the end of 2002 All-cause mortality was calculated as hazard risks ratios (HRs) Results: Among all participants, a total of 1238 men and 1169 women were in the sex-specific upper quintile of the somatic symptom distribution and qualified for ESR subpopulation. ESR participants were older, on a lower educational level, and more often unemployed They suffered more often from metabolic syndrome and chronic diseases ESR was associated with psychological distress, negative self-perceived health, and sleeping disorders ESR was associated with twofold more ambulant and hospital medical utilization. Survival in ESR participants was significantly reduced (HR=1.33; 95% CI=1.18-1.49, P<001) Frequency of medical ambulatory consultations and days in hospital were higher in ESR participants, even after controlling for potential confounders Conclusion: A simple approach to screen for participants with high symptom reporting in an unselected population-based sample results in the identification of a clinically meaningful target population with high burden of physical and psychological comorbidities (C) 2010 Elsevier Inc All rights reserved.
C1 [Ladwig, Karl Heinz; Lacruz, Maria Elena] Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Epidemiol, D-85764 Neuherberg, Germany.
   [Ladwig, Karl Heinz; Marten-Mittag, Birgitt; Henningsen, Peter] Tech Univ Munich, Klinikum Rechts Isar, Dept Psychosomat Med & Psychotherapy, D-8000 Munich, Germany.
   [Creed, Francis] Univ Manchester, Sch Med, Psychiat Res Grp, Manchester, Lancs, England.
C3 Helmholtz Association; Helmholtz-Center Munich - German Research Center
   for Environmental Health; Technical University of Munich; University of
   Manchester
RP Ladwig, KH (corresponding author), Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Epidemiol, D-85764 Neuherberg, Germany.
RI Ladwig, Karl-Heinz/B-5351-2014; Lacruz, Maria/KHV-7908-2024
OI Lacruz, Maria Elena/0000-0003-2036-3039
FU Helmholtz Zentrum Munchen, German Research Center for Environmental
   Health
FX The MONICA-KORA Augsburg studies are financed by the Helmholtz Zentrum
   Munchen, German Research Center for Environmental Health
CR [Anonymous], BESCHWERDE LISTE KLI
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NR 27
TC 33
Z9 37
U1 0
U2 9
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-3999
EI 1879-1360
J9 J PSYCHOSOM RES
JI J. Psychosomat. Res.
PD MAY
PY 2010
VL 68
IS 5
SI SI
BP 427
EP 437
DI 10.1016/j.jpsychores.2010.01.009
PG 11
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 589YK
UT WOS:000277189900005
PM 20403501
DA 2025-06-11
ER

PT J
AU Jaiswal, N
   Maurya, CK
   Arha, D
   Avisetti, DR
   Prathapan, A
   Raj, PS
   Raghu, KG
   Kalivendi, SV
   Tamrakar, AK
AF Jaiswal, Natasha
   Maurya, Chandan K.
   Arha, Deepti
   Avisetti, Deepa R.
   Prathapan, Ayyappan
   Raj, Palayyan S.
   Raghu, Kozhiparambil G.
   Kalivendi, Shasi V.
   Tamrakar, Akhilesh Kumar
TI Fructose induces mitochondrial dysfunction and triggers apoptosis in
   skeletal muscle cells by provoking oxidative stress
SO APOPTOSIS
LA English
DT Article
DE Fructose; Skeletal muscle; Mitochondrial dysfunction; Apoptosis;
   Oxidative stress
ID ANTIOXIDANT RESPONSE ELEMENT; ACTIVATED PROTEIN-KINASE; INDUCED
   DIABETIC-RATS; INSULIN-RESISTANCE; METABOLIC SYNDROME; MTDNA DAMAGE;
   DEATH; MECHANISMS; INDUCTION; INCREASE
AB Mitochondrial dysfunction in skeletal muscle has been implicated in the development of insulin resistance, a major characteristic of type 2 diabetes. There is evidence that oxidative stress results from the increased production of reactive oxygen species and reactive nitrogen species leads to mitochondrial dysfunction, tissue damage, insulin resistance, and other complications observed in type 2 diabetes. It has been suggested that intake of high fructose contributes to insulin resistance and other metabolic disturbances. However, there is limited information about the direct effect of fructose on the mitochondrial function of skeletal muscle, the major metabolic determinant of whole body insulin activity. Here, we assessed the effect of fructose exposure on mitochondria-mediated mechanisms in skeletal muscle cells. Exposure of L6 myotubes to high fructose stimulated the production of mitochondrial reactive oxygen species and nitric oxide (NO), and the expression of inducible NO synthase. Fructose-induced oxidative stress was associated with increased translocation of nuclear factor erythroid 2-related factor-2 to the nucleus, decreases in mitochondrial DNA content and mitochondrial dysfunctions, as evidenced by decreased activities of citrate synthase and mitochondrial dehydrogenases, loss of mitochondrial membrane potential, decreased activity of the mitochondrial respiratory complexes, and impaired mitochondrial energy metabolism. Furthermore, positive Annexin-propidium iodide staining and altered expression of Bcl-2 family members and caspases in L6 myotubes indicated that the cells progressively became apoptotic upon fructose exposure. Taken together, these findings suggest that exposure of skeletal muscle cells to fructose induced oxidative stress that decreased mitochondrial DNA content and triggered mitochondrial dysfunction, which caused apoptosis.
C1 [Jaiswal, Natasha; Maurya, Chandan K.; Arha, Deepti; Tamrakar, Akhilesh Kumar] CSIR Cent Drug Res Inst, Div Biochem, Lucknow 226031, Uttar Pradesh, India.
   [Avisetti, Deepa R.; Kalivendi, Shasi V.] CSIR Indian Inst Chem Technol, Ctr Chem Biol, Hyderabad 500007, Andhra Pradesh, India.
   [Prathapan, Ayyappan; Raj, Palayyan S.; Raghu, Kozhiparambil G.] CSIR Natl Inst Interdisciplinary Sci & Technol, Agroproc & Nat Prod Div, Thiruvananthapuram 695019, Kerala, India.
C3 Council of Scientific & Industrial Research (CSIR) - India; CSIR -
   Central Drug Research Institute (CDRI); Council of Scientific &
   Industrial Research (CSIR) - India; CSIR - Indian Institute of Chemical
   Technology (IICT); Council of Scientific & Industrial Research (CSIR) -
   India; CSIR - National Institute Interdisciplinary Science & Technology
   (NIIST)
RP Tamrakar, AK (corresponding author), CSIR Cent Drug Res Inst, Div Biochem, Lucknow 226031, Uttar Pradesh, India.
EM akhileshcdri@gmail.com
RI Raghu, K/AAT-8042-2021; arha, deepti/HKV-3088-2023; Maurya,
   Chandan/AAV-1813-2021; BAJWA, PROF.(DR.) DES RAJ/AAA-1007-2020
OI Palayyan, Salin Raj/0000-0003-0924-6229; BAJWA, PROF.(DR.) DES
   RAJ/0000-0002-4050-4778; Maurya, Chandan Kumar/0000-0003-2581-7415;
   Jaiswal, Natasha/0000-0003-4666-5430; Avisetti,
   Deepa/0000-0003-4744-1068; Ayyappan, Prathapan/0000-0002-5508-2360
FU Council of Scientific and Industrial Research (CSIR), New Delhi, India
   [BSC0102]; SMiLE [CSC0111]; University Grant Commission (UGC), New Delhi
FX The authors are thankful for financial support from the Council of
   Scientific and Industrial Research (CSIR), New Delhi, India in the form
   of network Project THUNDER (BSC0102) and SMiLE (CSC0111). The authors
   would also like to thank Dr. Amira Klip for providing L6 cells. NJ, CKM,
   DRA are supported by Senior Research Fellowship of University Grant
   Commission (UGC), New Delhi. We are thankful to Mr A.L. Vishwakarma,
   SAIF Division for flowcytometric analysis. This manuscript bears the
   CDRI Communication No. 8978.
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NR 58
TC 63
Z9 69
U1 1
U2 28
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1360-8185
EI 1573-675X
J9 APOPTOSIS
JI Apoptosis
PD JUL
PY 2015
VL 20
IS 7
BP 930
EP 947
DI 10.1007/s10495-015-1128-y
PG 18
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA CJ1HR
UT WOS:000355235200005
PM 25913123
DA 2025-06-11
ER

PT J
AU Konno, S
   Hirooka, Y
   Kishi, T
   Sunagawa, K
AF Konno, Satomi
   Hirooka, Yoshitaka
   Kishi, Takuya
   Sunagawa, Kenji
TI Sympathoinhibitory effects of telmisartan through the reduction of
   oxidative stress in the rostral ventrolateral medulla of obesity-induced
   hypertensive rats
SO JOURNAL OF HYPERTENSION
LA English
DT Article
DE angiotensin II; brain; hypertension; obesity; sympathetic nervous system
ID ACTIVATED RECEPTOR-GAMMA; ANGIOTENSIN-II; METABOLIC SYNDROME; AT(1)
   RECEPTOR; PRESSOR-RESPONSE; BLOOD-PRESSURE; SYMPATHOEXCITATION;
   ANTAGONIST; MODEL; PATHOGENESIS
AB Objectives: Sympathetic nervous system (SNS) activity is critically involved in the development and progression of obesity-induced hypertension. Angiotensin II type 1 receptor (AT(1)R)-induced oxidative stress in the rostral ventrolateral medulla (RVLM), a vasomotor center in the brainstem, activates the SNS in hypertensive rats. The aim of the present study was to determine whether oral administration of an AT(1)R blocker (ARB) inhibits SNS activity via antioxidative effects in the RVLM of rats with dietary-induced obesity.
   Methods and results: Obesity-prone rats fed a high-fat diet were divided into groups treated with either telmisartan obesity-prone (TLM-OP), or losartan obesity-prone (LOS-OP), or vehicle obesity-prone (VEH-OP). SBP, SNS activity, and oxidative stress in the RVLM were significantly higher in obesity-prone rats than in obesity-resistant rats. Body weight, visceral fat, blood glucose, serum insulin, and plasma adiponectin concentrations were significantly lower in TLM-OP and LOS-OP than in VEH-OP, and plasma adiponectin concentrations were significantly higher in TLM-OP than in LOS-OP. Although SBP was reduced to similar levels both in TLM-OP and LOS-OP, both oxidative stress in the RVLM and SNS activity were significantly lower in TLM-OP than in LOS-OP or VEH-OP.
   Conclusion: Orally administered telmisartan inhibited SNS activity through antioxidative effects via AT(1)R blockade in the RVLM of obesity-prone rats. AT(1)R and oxidative stress in the RVLM might be novel treatment targets for obesity-induced hypertension through sympathoinhibition, and telmisartan might be preferable for obesity-induced hypertension.
C1 [Hirooka, Yoshitaka] Kyushu Univ, Grad Sch Med Sci, Dept Adv Cardiovasc Regulat & Therapeut, Higashi Ku, Fukuoka 8128582, Japan.
   [Konno, Satomi; Sunagawa, Kenji] Kyushu Univ, Grad Sch Med Sci, Dept Cardiovasc Med, Fukuoka 8128582, Japan.
   [Kishi, Takuya] Kyushu Univ, Grad Sch Med Sci, Dept Adv Therapeut Cardiovasc Dis, Fukuoka 8128582, Japan.
C3 Kyushu University; Kyushu University; Kyushu University
RP Hirooka, Y (corresponding author), Kyushu Univ, Grad Sch Med Sci, Dept Adv Cardiovasc Regulat & Therapeut, Higashi Ku, 3-1-1 Maidashi, Fukuoka 8128582, Japan.
EM hyoshi@cardiol.med.kyushu-u.ac.jp
RI Kishi, Takuya/ITU-1075-2023
FU Japan Society for the Promotion of Science [B193290231]; Kimura Memorial
   Foundation Research Grant; Grants-in-Aid for Scientific Research
   [23220013] Funding Source: KAKEN
FX This study was supported by a Grant-in-Aid for Scientific Research from
   the Japan Society for the Promotion of Science (B193290231) and, in
   part, a Kimura Memorial Foundation Research Grant.
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NR 51
TC 39
Z9 43
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0263-6352
EI 1473-5598
J9 J HYPERTENS
JI J. Hypertens.
PD OCT
PY 2012
VL 30
IS 10
BP 1992
EP 1999
DI 10.1097/HJH.0b013e328357fa98
PG 8
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 006YA
UT WOS:000308854500020
PM 22902874
DA 2025-06-11
ER

PT J
AU Strenth, CR
   Mo, A
   Kale, NJ
   Day, PG
   Gonzalez, L
   Green, R
   Cruz, II
   Schneider, FD
AF Strenth, Chance R.
   Mo, Albert
   Kale, Neelima J.
   Day, Philip G.
   Gonzalez, Leo
   Green, Ronya
   Cruz, Inez I.
   Schneider, F. David
TI Adverse Childhood Experiences and Diabetes: Testing Violence and
   Distress Mediational Pathways in Family Medicine Patients
SO JOURNAL OF INTERPERSONAL VIOLENCE
LA English
DT Article
DE Child abuse; domestic violence; mental health and violence; diabetes
ID INTIMATE PARTNER VIOLENCE; SOCIAL DETERMINANTS; INTERPERSONAL VIOLENCE;
   SOCIOECONOMIC POSITION; HEALTH CONSEQUENCES; METABOLIC SYNDROME; CHRONIC
   DISEASE; PRIMARY-CARE; RISK-FACTORS; ABUSE
AB Type 2 diabetes mellitus (diabetes) is increasing in frequency and creating a significant burden on the United States healthcare system. Adverse childhood experiences (ACE) and interpersonal violence (IV) have been shown to have detrimental effects on mental and physical health. How ACE can influence IV as an adult and how this can influence the management of diabetes is not known. The purpose of the current study is to understand the relationship between violence and social determinants of health (SDoH), and its effect on patients with type 2 diabetes mellitus. A practiced-based research network (PBRN) of family medicine residency programs was utilized to collect cross-sectional data from seven family medicine residency program primary care clinics. In total, 581 participants with type 2 diabetes were recruited. A serial/parallel mediation model were analyzed. The majority of participants (58.3%) had a Hemoglobin A1c (HbA1c) that was not controlled. ACE was associated with an increase in Hurt-Insult-Threaten-Scream (HITS) scores, which in turn was positively associated with an increase in emotional burden, and finally, emotional burden decreased the likelihood that one's HbA1c was controlled (Effect = -.054, SE = .026 CI [-.115, -.013]). This indirect pathway remained significant even after controlling for several SDoH and gender. The impact of ACE persists into adulthood by altering behaviors that make adults more prone to experiencing family/partner violence. This in turn makes one more emotionally distressed about their diabetes, which influences how people manage their chronic condition. Family physicians should consider screening for both ACE and family/partner violence in those patients with poorly controlled diabetes.
C1 [Strenth, Chance R.; Gonzalez, Leo; Schneider, F. David] UT Southwestern Med Ctr, 5323 Harry Hines Blvd,K Bldg,2nd Floor,Suite 400, Dallas, TX 75390 USA.
   [Mo, Albert] Mem Hermann Hosp, Houston, TX USA.
   [Kale, Neelima J.] Univ Kentucky, Coll Med, Lexington, KY USA.
   [Day, Philip G.] Univ Massachusetts, Chan Med Sch, Worcester, MA 01605 USA.
   [Green, Ronya] TriStar Southern Hills Med Ctr, Nashville, TN USA.
   [Cruz, Inez I.] UT Hlth San Antonio, San Antonio, TX USA.
C3 University of Texas System; University of Texas Southwestern Medical
   Center Dallas; University of Kentucky; University of Massachusetts
   System; UMass Chan Medical School; University of Massachusetts
   Worcester; University of Texas System; University of Texas Health
   Science Center at San Antonio
RP Strenth, CR (corresponding author), UT Southwestern Med Ctr, 5323 Harry Hines Blvd,K Bldg,2nd Floor,Suite 400, Dallas, TX 75390 USA.
EM Chance.Strenth@UTSouthwestern.edu
RI Schneider, F/AAG-8146-2020
OI Schneider, David/0000-0002-9935-740X; Strenth,
   Chance/0000-0002-8921-3525; Gonzalez, Leo/0000-0002-3741-7817; Day,
   Philip/0000-0003-2713-0529
FU Texas Academy of Family Physicians Foundation (TAFP-F); Institute for
   Integration of Medicine and Science (IIMS), UT Health San Antonio, under
   the National Center for Advancing Translational Sciences (NCATS),
   National Institutes of Health (NIH) [UL1 TR002645]; National Center for
   Advancing Translational Sciences [UL1TR002645] Funding Source: NIH
   RePORTER
FX Acknowledging contributions from 10 clinics in seven RRNeT residency
   programs and their accompanying medical students. With funding from the
   Texas Academy of Family Physicians Foundation (TAFP-F) and the Institute
   for Integration of Medicine and Science (IIMS), UT Health San Antonio,
   under the National Center for Advancing Translational Sciences (NCATS),
   National Institutes of Health (NIH) through Grant UL1 TR002645. The
   content is solely the responsibility of the authors and does not
   necessarily represent the official views of the TAFP-F or NIH. The first
   author would also like to acknowledge the support he received from
   Tenzin Tsewang and Norbu Tsewang during the writing of this manuscript.
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NR 71
TC 4
Z9 4
U1 0
U2 5
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0886-2605
EI 1552-6518
J9 J INTERPERS VIOLENCE
JI J. Interpers. Violence
PD DEC
PY 2022
VL 37
IS 23-24
BP NP23035
EP NP23056
AR 08862605221076536
DI 10.1177/08862605221076536
EA FEB 2022
PG 22
WC Criminology & Penology; Family Studies; Psychology, Applied
WE Social Science Citation Index (SSCI)
SC Criminology & Penology; Family Studies; Psychology
GA 5W1BT
UT WOS:000764241800001
PM 35225043
DA 2025-06-11
ER

PT J
AU Chen, SS
   Shi, ML
   Chen, XL
   Le, QQ
   He, JL
AF Chen, Sisi
   Shi, Menglei
   Chen, Xiaolu
   Le, Qingqing
   He, Jianlin
TI Lactiplantibacillus Plantarum YDJ-03 and Limosilactobacillus
   fermentum YDJ-6 Alleviate Metabolic Syndrome in Mice
SO INTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCH
LA English
DT Article
DE hyperuricemia; hyperlipidemias; hyperglycemia; hypercholesterolemia;
   metabolic syndrome; probiotics
ID HIGH-FAT; LACTOBACILLUS-PLANTARUM; DIET; INFLAMMATION; MODEL
AB Background: Probiotics are increasingly recognized for promoting beneficial effects on intestinal health. However, most probiotic strains have been insufficiently researched, underscoring the need for further studies to fully understand their potential health benefits, especially in metabolic conditions. Therefore, this study aimed to explore the role and possible mechanism of Lactiplantibacillus plantarum YDJ-03 (YDJ-03) and Limosilactobacillus fermentum YDJ-6 (YDJ-6) in metabolic syndrome (MetS) and hyperuricemia.Methods: Twelve mice per group were fed a high-fat, high-fructose, high-cholesterol (HFFC) diet for 90 days. Mice in both the YDJ-03 and YDJ-6 groups were administered a dose of 1.2 x 109 colony-forming units (CFU) intragastrically per mouse for 28 days before being injected with hypoxanthine (400 mg/kg) to induce hyperuricemia. Blood lipids (triglycerides (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C)), liver injury markers (aspartate aminotransferase (AST) and alanine aminotransferase (ALT)), oxidative stress indicators (malondialdehyde (MDA) and superoxide dismutase (SOD)), and renal injury markers (uric acid (UA) and creatinine (CREA)) levels were analyzed after the conclusion of the study.Results: In contrast to the model group, the YDJ-03 group exhibited a marked decrease in liver TGs (p = 0.033), MDA (p = 0.0041), serum UA (p = 0.0071) and CREA (p = 0.0072). The mRNA levels of renal toll-like receptor 2 (Tlr2) (p = 0.0018), tumor necrosis factor receptor-associated factor 6 (Traf6) (p = 0.0013), and nuclear factor kappa B subunit 1 (Nfkb1) (p = 0.032) were downregulated, accompanied by marked attenuation of inflammatory cell infiltration in renal tissues and alleviation of glomerular epithelial cell swelling. Furthermore, YDJ-6 treatment promoted significant downward adjustments in hepatic TG (p = 0.0055), serum TG (p = 0.0082), and LDL-C (p = 0.0233) levels. YDJ-6 treatment also decreased serum ALT (p = 0.0458) and AST (p = 0.029) concentrations, downregulated the gene expression levels of inflammation-related adhesion G protein-coupled receptor E1 (Adgre1) (p = 0.033) and prostaglandin-endoperoxide synthase 2 (Ptgs2) (p = 0.0077), and effectively ameliorated hepatocellular lipid deposition and ballooning degeneration with hepatocyte necrosis.Conclusions: YDJ-03 may exert nephroprotective effects by regulating the TLR2-mediated NF-kappa B pathway, and YDJ-6 can effectively reduce hepatic fat deposition and inflammation to alleviate liver injury.
C1 [Chen, Sisi; Shi, Menglei; Chen, Xiaolu; Le, Qingqing; He, Jianlin] Minist Nat Resources, Inst Oceanog 3, Technol Innovat Ctr Exploitat Marine Biol Resource, Xiamen 361005, Fujian, Peoples R China.
C3 Third Institute of Oceanography, Ministry of Natural Resources; Ministry
   of Natural Resources of the People's Republic of China
RP He, JL (corresponding author), Minist Nat Resources, Inst Oceanog 3, Technol Innovat Ctr Exploitat Marine Biol Resource, Xiamen 361005, Fujian, Peoples R China.
EM jlhe@tio.org.cn
RI He, Jianlin/GWV-6561-2022
FU Scientific Research Foundation of Third Institute of Oceanography,
   Ministry of Natural Resources
FX The authors would like to acknowledge all colleagues for their help
   during the animal procedures and all the peer reviewers for their
   constructive feedback.
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NR 42
TC 0
Z9 0
U1 0
U2 0
PU IMR PRESS
PI ROBINSON
PA 112 ROBINSON RD, ROBINSON, SINGAPORE
SN 0300-9831
EI 1664-2821
J9 INT J VITAM NUTR RES
JI Int. J. Vitam. Nutr. Res.
PD APR 28
PY 2025
VL 95
IS 2
AR 31275
DI 10.31083/IJVNR31275
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 2AY4Z
UT WOS:001478331700003
PM 40298159
DA 2025-06-11
ER

PT J
AU Bakbak, E
   Terenzi, DC
   Trac, JZ
   Teoh, H
   Quan, A
   Glazer, SA
   Rotstein, OD
   Al-Omran, M
   Verma, S
   Hess, DA
AF Bakbak, Ehab
   Terenzi, Daniella C.
   Trac, Justin Z.
   Teoh, Hwee
   Quan, Adrian
   Glazer, Stephen A.
   Rotstein, Ori D.
   Al-Omran, Mohammed
   Verma, Subodh
   Hess, David A.
TI Lessons from bariatric surgery: Can increased GLP-1 enhance vascular
   repair during cardiometabolic-based chronic disease?
SO REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
LA English
DT Article
DE Type 2 Diabetes; Obesity; Bariatric surgery; Glucagon-like-peptide 1;
   Blood vessel repair and regeneration; Cardiovascular disease
ID GLUCAGON-LIKE PEPTIDE-1; ENDOTHELIAL PROGENITOR CELLS; MESENCHYMAL
   STEM-CELLS; C-REACTIVE PROTEIN; Y GASTRIC BYPASS; CARDIOVASCULAR
   OUTCOMES; WEIGHT-LOSS; ADIPOSE-TISSUE; METABOLIC SURGERY; MEDICAL
   THERAPY
AB Type 2 diabetes (T2D) and obesity represent entangled pandemics that accelerate the development of cardiovascular disease (CVD). Given the immense burden of CVD in society, non-invasive prevention and treatment strategies to promote cardiovascular health are desperately needed. During T2D and obesity, chronic dysglycemia and abnormal adiposity result in systemic oxidative stress and inflammation that deplete the vascular regenerative cell reservoir in the bone marrow that impairs blood vessel repair and exacerbates the penetrance of CVD co-morbidities. This novel translational paradigm, termed 'regenerative cell exhaustion' (RCE), can be detected as the depletion and dysfunction of hematopoietic and endothelial progenitor cell lineages in the peripheral blood of individuals with established T2D and/or obesity. The reversal of vascular RCE has been observed after administration of the sodium-glucose cotransporter-2 inhibitor (SGLT2i), empagliflozin, or after bariatric surgery for severe obesity. In this review, we explore emerging evidence that links improved dysglycemia to a reduction in systemic oxidative stress and recovery of circulating pro-vascular progenitor cell content required for blood vessel repair. Given that bariatric surgery consistently increases systemic glucagon-like-peptide 1 (GLP-1) release, we also focus on evidence that the use of GLP-1 receptor agonists (GLP-1RA) during obesity may act to inhibit the progression of systemic dysglycemia and adiposity, and indirectly reduce inflammation and oxidative stress, thereby limiting the impact of RCE. Therefore, therapeutic intervention with currently-available GLP-1RA may provide a less-invasive modality to reverse RCE, bolster vascular repair mechanisms, and improve cardiometabolic risk in individuals living with T2D and obesity.
C1 [Bakbak, Ehab; Terenzi, Daniella C.; Trac, Justin Z.; Teoh, Hwee; Quan, Adrian; Verma, Subodh; Hess, David A.] St Michaels Hosp, Div Cardiac Surg, Toronto, ON, Canada.
   [Al-Omran, Mohammed] St Michaels Hosp, Div Vasc Surg, Toronto, ON, Canada.
   [Teoh, Hwee; Rotstein, Ori D.] St Michaels Hosp, Div Endocrinol & Metab, Toronto, ON, Canada.
   [Bakbak, Ehab; Terenzi, Daniella C.; Trac, Justin Z.; Teoh, Hwee; Quan, Adrian; Rotstein, Ori D.; Al-Omran, Mohammed; Verma, Subodh; Hess, David A.] St Michaels Hosp, Keenan Res Ctr Biomed Sci, Toronto, ON, Canada.
   [Bakbak, Ehab; Terenzi, Daniella C.; Trac, Justin Z.; Teoh, Hwee; Quan, Adrian; Rotstein, Ori D.; Al-Omran, Mohammed; Verma, Subodh; Hess, David A.] St Michaels Hosp, Li Ka Shing Knowledge Inst, Toronto, ON, Canada.
   [Bakbak, Ehab; Trac, Justin Z.; Al-Omran, Mohammed; Verma, Subodh; Hess, David A.] Univ Toronto, Dept Pharmacol & Toxicol, Toronto, ON, Canada.
   [Terenzi, Daniella C.; Rotstein, Ori D.; Al-Omran, Mohammed; Verma, Subodh] Univ Toronto, Inst Med Sci, Toronto, ON, Canada.
   [Al-Omran, Mohammed; Verma, Subodh] Univ Toronto, Dept Surg, Toronto, ON, Canada.
   [Hess, David A.] Robarts Res Inst, Mol Med Res Labs, London, ON, Canada.
   [Hess, David A.] Western Univ, Dept Physiol & Pharmacol, London, ON, Canada.
   [Glazer, Stephen A.] Humber River Hosp, Dept Internal Med, Toronto, ON, Canada.
   [Glazer, Stephen A.] Queens Univ, Div Endocrinol & Metab, Kingston, ON, Canada.
C3 University of Toronto; Saint Michaels Hospital Toronto; University of
   Toronto; Saint Michaels Hospital Toronto; University of Toronto; Saint
   Michaels Hospital Toronto; University of Toronto; Saint Michaels
   Hospital Toronto; University of Toronto; Li Ka Shing Knowledge
   Institute; Saint Michaels Hospital Toronto; University of Toronto;
   University of Toronto; University of Toronto; Western University
   (University of Western Ontario); University Western Ontario Hospital;
   Western University (University of Western Ontario); Queens University -
   Canada
RP Hess, DA (corresponding author), St Michaels Hosp, Div Cardiac Surg, Toronto, ON, Canada.; Hess, DA (corresponding author), St Michaels Hosp, Keenan Res Ctr Biomed Sci, Toronto, ON, Canada.; Hess, DA (corresponding author), St Michaels Hosp, Li Ka Shing Knowledge Inst, Toronto, ON, Canada.; Hess, DA (corresponding author), Univ Toronto, Dept Pharmacol & Toxicol, Toronto, ON, Canada.; Hess, DA (corresponding author), Robarts Res Inst, Mol Med Res Labs, London, ON, Canada.; Hess, DA (corresponding author), Western Univ, Dept Physiol & Pharmacol, London, ON, Canada.
EM dhess@robarts.ca
RI Al-Omran, Mohammed/IXX-0542-2023; Verma, Subodh/HCH-3619-2022; Teoh,
   Hwee/F-2498-2018; Hess, David/M-2828-2013
OI Bakbak, Ehab/0000-0003-4687-6553; Hess, David/0000-0003-2186-3166
FU Canadian Institutes of Health Research (CIHR) [378189]; Amarin; Amgen;
   AstraZeneca; Bayer; Boehringer Ingelheim; Bristol-Myers Squibb; Eli
   Lilly; EOCI Pharmacomm Ltd; HLS Therapeutics; Janssen; Merck; Novartis;
   Novo Nordisk; Pfizer; PhaseBio; Sanofi; Sun Pharmaceuticals; Toronto
   Knowledge Translation Working Group
FX This work was supported by funding from the Canadian Institutes of
   Health Research (CIHR) grant (MOP#378189). S.V. reports receiving
   research grants and/or speaking honoraria from Amarin, Amgen,
   AstraZeneca, Bayer, Boehringer Ingelheim, Bristol-Myers Squibb, Eli
   Lilly, EOCI Pharmacomm Ltd, HLS Therapeutics, Janssen, Merck, Novartis,
   Novo Nordisk, Pfizer, PhaseBio, Sanofi, Sun Pharmaceuticals, and the
   Toronto Knowledge Translation Working Group; he is also the President of
   the Canadian Medical and Surgical Knowledge Translation Research Group,
   a federally incorporated not-for-profit physician organization. No other
   authors have anything to disclose.
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NR 152
TC 21
Z9 24
U1 0
U2 13
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1389-9155
EI 1573-2606
J9 REV ENDOCR METAB DIS
JI Rev. Endocr. Metab. Disord.
PD DEC
PY 2021
VL 22
IS 4
BP 1171
EP 1188
DI 10.1007/s11154-021-09669-7
EA JUL 2021
PG 18
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA XZ9SD
UT WOS:000670161800001
PM 34228302
DA 2025-06-11
ER

PT J
AU Flynn, S
   Srikanthan, P
   Ravellette, K
   Inoue, K
   Watson, K
   Horwich, T
AF Flynn, Spencer
   Srikanthan, Preethi
   Ravellette, Keeley
   Inoue, Kosuke
   Watson, Karol
   Horwich, Tamara
TI Urinary cortisol and cardiovascular events in women vs. men: The
   multi-ethnic study of atherosclerosis
SO AMERICAN HEART JOURNAL PLUS: CARDIOLOGY RESEARCH AND PRACTICE
LA English
DT Article
DE Stress; Body composition; Cardiovascular events; Atherosclerosis
ID CORONARY-ARTERY CALCIUM; PITUITARY-ADRENAL AXIS; BODY-FAT DISTRIBUTION;
   MYOCARDIAL-INFARCTION; METABOLIC SYNDROME; SEX-DIFFERENCES;
   HEART-DISEASE; RISK-FACTORS; STRESS; OBESITY
AB Research suggests that women experience greater cardiovascular ischemic effects from stress than men. Visceral adiposity is an endocrine tissue that differs by sex and interacts with stress hormones. We hypothesized that urinary cortisol would be associated with increased cardiovascular events and change in coronary artery calcium score (CAC) in women, and these relationships would vary by central obesity. In the Multi-Ethnic Study of Atherosclerosis Stress Ancillary study, cortisol was quantified by 12-h overnight urine collection. Central obesity was estimated by waist-hip ratio (WHR). Multivariable Cox models estimated the relationship between cortisol and cardiovascular events and assessed for moderation by WHR. The relationship between cortisol and change in CAC Agatston score was assessed by Tobit regression models. 918 patients were analyzed with median follow up of 11 years. There was no association between urinary cortisol and cardiovascular events in the cohort. However, in individuals with below median WHR, higher urinary cortisol levels (upper tertile) were associated with higher cardiovascular event rates in the full cohort, women, and men, but not in groups with above median WHR. There was significant moderation by WHR in women, but not men, whereby the association between elevated cortisol and increased cardiovascular events diminished as WHR increased. Urinary cortisol was associated with increased change in CAC in women (P = 0.003) but not men, without moderation by WHR. Our study highlights associations between cortisol and subclinical atherosclerosis in women, and moderation of the relationship between cortisol and cardiovascular events by central obesity in both genders.
C1 [Flynn, Spencer; Ravellette, Keeley] UCLA, David Geffen Sch Med, Los Angeles, CA USA.
   [Srikanthan, Preethi] UCLA, Div Endocrinol, Los Angeles, CA USA.
   [Inoue, Kosuke] Kyoto Univ, Dept Social Epidemiol, Kyoto, Japan.
   [Watson, Karol; Horwich, Tamara] UCLA, Div Cardiol, Los Angeles, CA USA.
   [Horwich, Tamara] 10833 Le Conte Ave,CHS A2-237, Los Angeles, CA 90095 USA.
C3 University of California System; University of California Los Angeles;
   University of California Los Angeles Medical Center; David Geffen School
   of Medicine at UCLA; University of California System; University of
   California Los Angeles; Kyoto University; University of California
   System; University of California Los Angeles
RP Horwich, T (corresponding author), 10833 Le Conte Ave,CHS A2-237, Los Angeles, CA 90095 USA.
EM thorwich@mednet.ucla.edu
RI Watson, Karol/ABD-7425-2021
FU National Heart, Lung, and Blood Institute [75N92020D00001,
   HHSN268201500003I, N01-HC-95159, 75N92020D00005, N01-HC-95160,
   75N92020D00002, N01-HC-95161, 75N92020D00003, N01-HC-95162,
   75N92020D00006, N01-HC-95163, 75N92020D00004, N01-HC-95164,
   75N92020D00007, N01-HC-95165, N01-HC-95166, N01-HC-95167, N01-HC-95168,
   N01-HC-95169]; National Center for Advancing Translational Sciences
   (NCATS) [UL1-TR-000040, UL1-TR-001079, UL1-TR-001420]
FX The MESA study was supported by contracts 75N92020D00001,
   HHSN268201500003I, N01-HC-95159, 75N92020D00005, N01-HC-95160,
   75N92020D00002, N01-HC-95161, 75N92020D00003, N01-HC-95162,
   75N92020D00006, N01-HC-95163, 75N92020D00004, N01-HC-95164,
   75N92020D00007, N01-HC-95165, N01-HC-95166, N01-HC-95167, N01-HC-95168
   and N01-HC-95169 from the National Heart, Lung, and Blood Institute, and
   by grants UL1-TR-000040, UL1-TR-001079, and UL1-TR-001420 from the
   National Center for Advancing Translational Sciences (NCATS) . Study
   sponsors were not involved in study design, data interpretation,
   writing, or the decision to submit the article for publication. The
   funders had no role in the design and conduct of the study; collection,
   management, analysis, and interpretation of the data; preparation,
   review, or approval of the article; and decision to submit the article
   for publication.
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NR 51
TC 1
Z9 1
U1 0
U2 0
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
EI 2666-6022
J9 AM HEART J PLUS
JI Am. Heart J. Plus-Cardiol. Res. Pract.
PD DEC
PY 2023
VL 36
AR 100344
DI 10.1016/j.ahjo.2023.100344
EA NOV 2023
PG 9
WC Cardiac & Cardiovascular Systems
WE Emerging Sources Citation Index (ESCI)
SC Cardiovascular System & Cardiology
GA DR8M6
UT WOS:001133887100001
PM 37982128
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Cervellati, C
   Bonaccorsi, G
   Trentini, A
   Valacchi, G
   Sanz, JM
   Squerzanti, M
   Spagnolo, M
   Massari, L
   Crivellari, I
   Greco, P
   Parladori, R
   Passaro, A
   Ricci, G
AF Cervellati, Carlo
   Bonaccorsi, Gloria
   Trentini, Alessandro
   Valacchi, Giuseppe
   Sanz, Juana M.
   Squerzanti, Monica
   Spagnolo, Manuela
   Massari, Leo
   Crivellari, Ilaria
   Greco, Pantaleo
   Parladori, Roberta
   Passaro, Angelina
   Ricci, Giorgio
TI Paraoxonase, arylesterase and lactonase activities of paraoxonase-1
   (PON1) in obese and severely obese women
SO SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION
LA English
DT Article
DE Arylesterase; body mass index; markers of oxidative stress; obesity;
   paraoxonase-1
ID HIGH-DENSITY-LIPOPROTEIN; CORONARY-ARTERY-DISEASE; MACROPHAGE
   CHOLESTEROL EFFLUX; MILD COGNITIVE IMPAIRMENT; SYSTEMIC OXIDATIVE
   STRESS; SERUM PARAOXONASE; LIPID HYDROPEROXIDES; POSTMENOPAUSAL WOMEN;
   ALZHEIMERS-DISEASE; METABOLIC SYNDROME
AB Obesity is independently associated with disturbances in lipid and lipoprotein metabolism, oxidative stress, and is a well-established independent risk factor for cardiovascular diseases (CVD). Human paraoxonase 1 (PON1) is a pleotropic high-density lipoprotein (HDL)-associated enzyme with antioxidant and anti-inflammatory proprieties that have been suggested to contribute to the athero-protective function of the lipoprotein. The aim of this study was to investigate whether obesity is associated with PON1 activity and whether this association is influenced by oxidative stress, inflammation and HDL cholesterol (HDL-C) concentration. The promiscuous activities, arylesterase and paraoxonase, and the putative physiological activity, lactonase, of PON1 were assessed in the serum of 214 obese and severely obese, 101 overweight and 129 normal-weight women. Levels of high-sensitivity C-reactive protein (hs-CRP), hydroperoxides (by-products of lipid oxidative damage) and lipid profiles were also evaluated. Arylesterase activity was the only activity that significantly differed across the groups (ANOVA, p<.01), with the greatest decrease observed in individuals with body mass index (BMI)>40kg/m(2) compared to controls (p<.001). This activity was also inversely, although weakly (r=-0.160, p<.001) correlated with the BMI, and the association was independent of age and levels of oxidative stress and inflammation, but not of HDL-C concentration. In conclusion, our results suggest that the apparent obesity-associated decrement of PON1 activity might simply reflect the decrease in concentration of its plasmatic carrier.
C1 [Cervellati, Carlo; Trentini, Alessandro; Squerzanti, Monica; Spagnolo, Manuela; Crivellari, Ilaria] Univ Ferrara, Sect Med Biochem Mol Biol & Genet, Dept Biomed & Specialist Surg Sci, Via Luigi Borsari 46, I-44121 Ferrara, Italy.
   [Bonaccorsi, Gloria; Massari, Leo; Greco, Pantaleo] Univ Ferrara, Menopause & Osteoporosis Ctr, Dept Morphol Surg & Expt Med, Ferrara, Italy.
   [Bonaccorsi, Gloria; Greco, Pantaleo] Univ Ferrara, Sect Obstet & Gynecol, Dept Morphol Surg & Expt Med, Ferrara, Italy.
   [Valacchi, Giuseppe] Univ Ferrara, Dept Life Sci & Biotechnol, Ferrara, Italy.
   [Valacchi, Giuseppe] NC State Univ, Plants Human Hlth Inst, Dept Anim Sci, NC Res Campus, Kannapolis, NC USA.
   [Sanz, Juana M.; Passaro, Angelina] Univ Ferrara, Sect Internal Med Gerontol & Geriatr, Dept Med Sci, Ferrara, Italy.
   [Parladori, Roberta; Ricci, Giorgio] Univ Ferrara, Postgrad Sch Digest Dis, Dept Med Sci, Ferrara, Italy.
C3 University of Ferrara; University of Ferrara; University of Ferrara;
   University of Ferrara; North Carolina State University; University of
   Ferrara; University of Ferrara
RP Cervellati, C (corresponding author), Univ Ferrara, Sect Med Biochem Mol Biol & Genet, Dept Biomed & Specialist Surg Sci, Via Luigi Borsari 46, I-44121 Ferrara, Italy.
EM crvcrl@unife.it
RI Massari, Leo/I-1965-2019; Trentini, Alessandro/G-6215-2011; BONACCORSI,
   GLORIA/AAC-6164-2022; Sanz, Juana/AAF-7941-2020; Greco,
   Pantaleo/AAC-5173-2022; Spagnolo, Manuela/AAL-1503-2021; Cervellati,
   Carlo/K-6453-2015; Passaro, Angelina/P-3401-2015
OI Massari, Leo/0000-0001-6198-2122; Spagnolo, Manuela/0000-0003-1262-8447;
   Sanz Molina, Juana Maria/0000-0003-3372-2758; GRECO,
   Pantaleo/0000-0003-2461-6777; Cervellati, Carlo/0000-0003-4777-6300;
   Passaro, Angelina/0000-0001-8462-7000
FU 'Local Research Project' grant from University of Ferrara
FX The present study was financed by 'Local Research Project' grant from
   University of Ferrara.
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NR 51
TC 25
Z9 26
U1 0
U2 6
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0036-5513
EI 1502-7686
J9 SCAND J CLIN LAB INV
JI Scand. J. Clin. Lab. Invest.
PY 2018
VL 78
IS 1-2
BP 18
EP 24
DI 10.1080/00365513.2017.1405274
PG 7
WC Medical Laboratory Technology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology; Research & Experimental Medicine
GA FW0AE
UT WOS:000424952600004
PM 29168398
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Banse, HE
   Frank, N
   Kwong, GPS
   McFarlane, D
AF Banse, Heidi E.
   Frank, Nicholas
   Kwong, Grace P. S.
   McFarlane, Dianne
TI Relationship of oxidative stress in skeletal muscle with obesity and
   obesity-associated hyperinsulinemia in horses
SO CANADIAN JOURNAL OF VETERINARY RESEARCH-REVUE CANADIENNE DE RECHERCHE
   VETERINAIRE
LA English
DT Article
ID IRS-1 SERINE PHOSPHORYLATION; INSULIN-RESISTANCE; MITOCHONDRIAL
   DYSFUNCTION; IN-VIVO; ANTIOXIDANT CAPACITY; LIPID-PEROXIDATION;
   METABOLIC SYNDROME; REACTIVE OXYGEN; PONIES; LAMINITIS
AB In horses, hyperinsulinemia and insulin resistance (insulin dysregulation) are associated with the development of laminitis. Although obesity is associated with insulin dysregulation, the mechanism of obesity-associated insulin dysregulation remains to be established. We hypothesized that oxidative stress in skeletal muscle is associated with obesity-associated hyperinsulinemia in horses. Thirty-five light breed horses with body condition scores (BCS) of 3/9 to 9/9 were studied, including 7 obese, normoinsulinemic (BCS >= 7, resting serum insulin < 30 mu IU/mL) and 6 obese, hyperinsulinemic (resting serum insulin >= 30 mu IU/mL) horses. Markers of oxidative stress (oxidative damage, mitochondrial function, and antioxidant capacity) were evaluated in skeletal muscle biopsies. A Spearman's rank correlation coefficient was used to determine relationships between markers of oxidative stress and BCS. Furthermore, to assess the role of oxidative stress in obesity-related hyperinsulinemia, markers of antioxidant capacity and oxidative damage were compared among lean, normoinsulinemic (L-NI); obese, normoinsulinemic (O-NI); and obese, hyperinsulinemic (O-HI) horses. Increasing BCS was associated with an increase in gene expression of a mitochondrial protein responsible for mitochondrial biogenesis (estrogen-related receptor alpha, ERR alpha) and with increased antioxidant enzyme total superoxide dismutase (TotSOD) activity. When groups (L-NI, O-NI, and O-HI) were compared, TotSOD activity was increased and protein carbonyls, a marker of oxidative damage, decreased in the O-HI compared to the L-NI horses. These findings suggest that a protective antioxidant response occurred in the muscle of obese animals and that obesity-associated oxidative damage in skeletal muscle is not central to the pathogenesis of equine hyperinsulinemia.
C1 [Banse, Heidi E.; McFarlane, Dianne] Oklahoma State Univ, Ctr Vet Hlth Sci, Dept Physiol Sci, Stillwater, OK 74078 USA.
   [Frank, Nicholas] Tufts Univ, Cummings Sch Vet Med, Dept Clin Sci, North Grafton, MA 01536 USA.
   [Kwong, Grace P. S.] Univ Calgary, Fac Vet Med, Calgary, AB T2N 4Z6, Canada.
C3 Oklahoma State University System; Oklahoma State University -
   Stillwater; Tufts University; University of Calgary
RP Banse, HE (corresponding author), Univ Calgary, Fac Vet Med, Dept Vet Clin & Diagnost Sci, 3280 Hosp Dr, Calgary, AB T2N 4Z6, Canada.
EM hebanse@ucalgary.ca
OI Banse, Heidi/0000-0002-0120-0376; Kwong, Grace Pui
   Sze/0000-0002-9081-6059
FU American Quarter Horse Association; Oklahoma State University Research
   Advisory Committee
FX Funding was provided by the American Quarter Horse Association and the
   Oklahoma State University Research Advisory Committee. The authors thank
   Kim Hill and Kristen McDaniel for technical assistance.
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NR 46
TC 15
Z9 19
U1 0
U2 12
PU CANADIAN VET MED ASSOC
PI OTTAWA
PA 339 BOOTH ST, OTTAWA, ONTARIO K1R 7K1, CANADA
SN 0830-9000
J9 CAN J VET RES
JI Can. J. Vet. Res.-Rev. Can. Rech. Vet.
PD OCT
PY 2015
VL 79
IS 4
BP 329
EP 338
PG 10
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA CW4MV
UT WOS:000364966600011
PM 26424915
DA 2025-06-11
ER

PT J
AU Naowaboot, J
   Wannasiri, S
   Pannangpetch, P
AF Naowaboot, Jarinyaporn
   Wannasiri, Supaporn
   Pannangpetch, Patchareewan
TI Morin attenuates hepatic insulin resistance in high-fat-diet-induced
   obese mice
SO JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
LA English
DT Article
DE Morin; Obesity; Insulin resistance; Oxidative stress; Inflammation
ID INDUCED DIABETIC-RATS; BETA-CELL FUNCTION; FACTOR-KAPPA-B; OXIDATIVE
   STRESS; METABOLIC SYNDROME; ADIPOSE-TISSUE; LEPTIN RESISTANCE; LIVER;
   STEATOSIS; INFLAMMATION
AB Morin is a natural bioflavonoid that exhibits antioxidant and anti-inflammatory properties. The present study was designed to evaluate the effect of morin on insulin resistance, oxidative stress, and inflammation in a high-fat-diet (HFD)-induced obese mice. Obesity was induced in ICR mice by feeding a HFD (60 % kcal from fat) for 12 weeks. After the first 6 weeks, obese mice were treated with morin (50 or 100 mg/kg/day) once daily for further 6 weeks. Blood glucose, lipid profile, insulin, leptin, adiponectin, and markers of oxidative stress and inflammation were then measured. Liver was excised, subjected to histopathology, glycogen determination, and gene and protein expression analysis. Morin administration reduced blood glucose, serum insulin, leptin, malondialdehyde, interleukin-6 (IL-6), and monocyte chemoattractant protein-1 (MCP-1) levels and increased serum adiponectin levels. Moreover, there was a reduction in serum lipid and liver triglyceride levels. Liver histology indicated that morin limited accumulation of lipid droplets. Interestingly, morin reduced expression of hepatic sterol regulatory element binding protein 1c (SREBP1c), fatty acid synthase (FAS), and acetyl-CoA carboxylase (ACC) and up-regulated hepatic carnitine palmitoyltransferase 1a (CPT1a) expression. Morin also stimulated glycogen storage and suppressed phosphoenolpyruvate carboxykinase (PEPCK) and glucose-6-phosphatase (G6Pase) protein expression. Furthermore, hepatic superoxide dismutase (SOD) and catalase (CAT) expression were increased after morin treatment. These findings indicate that morin has a positive effect in the HFD-induced obesity condition by suppressing lipogenesis, gluconeogenesis, inflammation, and oxidative stress activities.
C1 [Naowaboot, Jarinyaporn] Thammasat Univ, Fac Med, Dept Preclin Sci, Div Pharmacol, Rangsit Campus, Pathum Thani 12120, Thailand.
   [Wannasiri, Supaporn] Thammasat Univ, Fac Med, Dept Preclin Sci, Div Physiol, Rangsit Campus, Pathum Thani 12120, Thailand.
   [Pannangpetch, Patchareewan] Khon Kaen Univ, Fac Med, Dept Pharmacol, Khon Kaen 40002, Thailand.
C3 Thammasat University; Thammasat University; Khon Kaen University
RP Naowaboot, J (corresponding author), Thammasat Univ, Fac Med, Dept Preclin Sci, Div Pharmacol, Rangsit Campus, Pathum Thani 12120, Thailand.
EM naowaboot@yahoo.com
FU Faculty of Medicine, Thammasat University [GEN2-15/2015]
FX This research was supported by the research grant from the Faculty of
   Medicine, Thammasat University (Contract number: GEN2-15/2015).
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NR 46
TC 37
Z9 38
U1 0
U2 11
PU SERVICIO PUBLICACIONES UNIVERSIDAD NAVARRA
PI PAMPLONA
PA CAMPUS UNIV, CARRETERA DEL SADAR S-N, APARTADO 177, 31080 PAMPLONA,
   SPAIN
SN 1138-7548
EI 1877-8755
J9 J PHYSIOL BIOCHEM
JI J. Physiol. Biochem.
PD JUN
PY 2016
VL 72
IS 2
BP 269
EP 280
DI 10.1007/s13105-016-0477-5
PG 12
WC Biochemistry & Molecular Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Physiology
GA DM6RF
UT WOS:000376479400012
PM 26976296
DA 2025-06-11
ER

PT J
AU Pucci, G
   Alcidi, R
   Tap, L
   Battista, F
   Mattace-Raso, F
   Schillaci, G
AF Pucci, Giacomo
   Alcidi, Riccardo
   Tap, Lisanne
   Battista, Francesca
   Mattace-Raso, Francesco
   Schillaci, Giuseppe
TI Sex- and gender-related prevalence, cardiovascular risk and therapeutic
   approach in metabolic syndrome: A review of the literature
SO PHARMACOLOGICAL RESEARCH
LA English
DT Review
DE Metabolic syndrome; Cardiovascular risk; Insulin-resistance; Gender
   differences; Sex hormones; Lifestyle treatment
ID POLYCYSTIC-OVARY-SYNDROME; LIFE-STYLE-MODIFICATION;
   CORONARY-HEART-DISEASE; TYPE-2 DIABETES-MELLITUS; BODY-MASS INDEX;
   DIETARY PATTERNS; NATIONAL-HEALTH; ALL-CAUSE; MYOCARDIAL-INFARCTION;
   INSULIN-RESISTANCE
AB Metabolic syndrome (MS), a cluster of metabolic abnormalities linked to insulin-resistance and abdominal obesity, is associated with an increased risk of Type II diabetes mellitus (DM) and cardiovascular (CV) disease. Its prevalence is high, affecting 20%-30% of the general population, and increases with age in a sex-specific manner: in fact, while below 50 years it is slightly higher in men, it reverses after 50 years. The pronounced age-related increase in the prevalence of MS in women occurs as the result of several factors, which may be classified into sex- and gender-related factors. Sex-related factors, linked to genetical and biological pathways, are mainly driven by hyperandrogenism, insulin-resistance, and the associated increase in abdominal obesity and HDL-cholesterol reduction occurring after menopause. Gender-related factors are sensitive to social and cultural behaviors, dietary habits and psychosocial factors. Women are more prone than men to develop MS in response to work stress and low socio-economic status.
   Sex and gender differences in the prevalence of MS may translate in different CV risk associated. Prospective studies suggest that the CV risk in women with MS is not only equal but also superior to the CV risk of men with MS. This difference is mostly attenuated when adjusting for the presence of overt DM. Despite similar odds for CV events, the number of CV events may be higher in elderly women because of the higher prevalence of MS compared to men in this age group.
   Men and women may also have a differential response to treatments for MS, such as lifestyle measures and weight loss. Recent observations suggest that men are better responders than women to non-pharmaceutical therapeutic strategies aimed at reducing the prevalence of MS, although this should be confirmed in large-scale studies. The present review describes the impact of sex and gender on the prevalence, clinical presentation, prognostic significance and treatment of the MS. Attention to gender specificities should be a mandatory pre-requisite of clinical and epidemiological research on MS and CV disease, for a better knowledge and development of health strategies. (C) 2017 Elsevier Ltd. All rights reserved.
C1 [Pucci, Giacomo; Alcidi, Riccardo; Battista, Francesca; Schillaci, Giuseppe] Univ Perugia, Dipartimento Med, Perugia, Italy.
   [Pucci, Giacomo; Alcidi, Riccardo; Battista, Francesca; Schillaci, Giuseppe] Azienda Osped Univ Terni, Struttura Complessa Med Interna, Terni, Italy.
   [Tap, Lisanne; Mattace-Raso, Francesco] Erasmus Univ, Med Ctr, Dept Internal Med, Div Geriatr, Rotterdam, Netherlands.
C3 University of Perugia; Erasmus University Rotterdam; Erasmus MC
RP Pucci, G (corresponding author), Univ Perugia, Azienda Osped Univ Terni, Struttura Complessa Med Interna, Dipartimento Med, Piazzale Tristano Joannuccio,1, IT-05100 Terni, Italy.
EM giacomo.pucci@gmail.com
RI BATTISTA, FRANCESCA/AAX-3260-2020; Raso, Francesco/L-2541-2015;
   paciullo, francesco/K-1060-2018; PUCCI, Giacomo/K-3723-2016
OI Tap, Lisanne/0000-0003-2989-4063; Mattace-Raso,
   Francesco/0000-0002-1688-6497; PUCCI, Giacomo/0000-0003-0180-859X;
   Battista, Francesca/0000-0003-0760-1354
FU Fondazione Cassa di Risparmio di Terni e Narni
FX The position of Giacomo Pucci as an Adjunct Assistant Professor at the
   University of Perugia was funded by a grant from the Fondazione Cassa di
   Risparmio di Terni e Narni.
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NR 87
TC 292
Z9 311
U1 4
U2 104
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 1043-6618
EI 1096-1186
J9 PHARMACOL RES
JI Pharmacol. Res.
PD JUN
PY 2017
VL 120
BP 34
EP 42
DI 10.1016/j.phrs.2017.03.008
PG 9
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Pharmacology & Pharmacy
GA EV6MI
UT WOS:000401883100004
PM 28300617
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Nano, J
   Muka, T
   Cepeda, M
   Voortman, T
   Dhana, K
   Brahimaj, A
   Dehghan, A
   Franco, OH
AF Nano, J.
   Muka, T.
   Cepeda, M.
   Voortman, T.
   Dhana, K.
   Brahimaj, A.
   Dehghan, A.
   Franco, O. H.
TI Association of circulating total bilirubin with the metabolic syndrome
   and type 2 diabetes: A systematic review and meta-analysis of
   observational evidence
SO DIABETES & METABOLISM
LA English
DT Review
DE Bilirubin; Meta-analysis; Metabolic syndrome; Systematic review; Type 2
   diabetes
ID CORONARY-HEART-DISEASE; MIDDLE-AGED ADULTS; C-REACTIVE PROTEIN; SERUM
   BILIRUBIN; RISK-FACTOR; UGT1A1-ASTERISK-28 ALLELE; MENDELIAN
   RANDOMIZATION; OXIDATIVE STRESS; GILBERT-SYNDROME; HEALTH
AB Objective. Emerging evidence suggests that bilirubin levels might be associated with the metabolic syndrome (MetS) and type 2 diabetes (T2D), although the nature of the association remains unclear.
   Design. This systematic review and meta-analysis investigated the relationship between total plasma bilirubin and the risk of MetS and T2D.
   Data sources. Relevant studies were identified using five databases (Embase, Medline [Ovid], Web of Science, PubMed, Cochrane Central and Google Scholar), with the last search done on 21 October 2015.
   Study references were checked and authors contacted to identify additional studies. Study selection. Randomized controlled trials, and cohort, case-control and cross-sectional studies of adults examining the association between blood bilirubin levels and MetS and T2D were included, irrespective of language and date of publication. Abstract and full-text selection was done by two independent reviewers, with a third reviewer available in case of disagreement.
   Data extraction. Data were extracted by two independent reviewers using a predesigned data collection form.
   Main outcomes and measures. MetS and T2D.
   Methods. Summary estimates were obtained by random-effects meta-analysis.
   Results. Of the 2313 searched references, 16 observational studies (11 cross-sectional, two prospective, one that was both cross-sectional and prospective, two retrospective and one national survey) met our inclusion criteria. Overall, data were available for 175,911 non-overlapping participants, including 7414 MetS cases and 9406 T2D cases. In the meta-analysis of seven cross-sectional studies, the pooled odds ratio (95% confidence interval) for MetS in a comparison of extreme tertiles of serum bilirubin levels was 0.70 (95% CI: 0.62, 0.78), whereas no significant association was found for the pooled estimated relative risk between two prospective studies (0.57, 95% CI: 0.11, 2.94). The corresponding estimate was 0.77 (95% CI: 0.67, 0.87) for T2D from four cross-sectional studies.
   Conclusion. The available evidence, mainly from cross-sectional studies, supports an inverse association of bilirubin levels with adverse metabolic outcomes. Large-scale prospective studies are now needed to establish whether bilirubin levels may be useful in the prevention of MetS and T2D. (C) 2016 Elsevier Masson SAS. All rights reserved.
C1 [Nano, J.; Muka, T.; Cepeda, M.; Voortman, T.; Dhana, K.; Brahimaj, A.; Dehghan, A.; Franco, O. H.] Erasmus Univ, Med Ctr, Dept Epidemiol, POB 2040, NL-3000 CA Rotterdam, Netherlands.
C3 Erasmus University Rotterdam; Erasmus MC
RP Franco, OH (corresponding author), Erasmus Univ, Med Ctr, Dept Epidemiol, POB 2040, NL-3000 CA Rotterdam, Netherlands.
EM o.franco@erasmusmc.nl
RI Franco, Óscar/ABE-2305-2020; Dehghan, Abbas/ABE-7377-2020; Nano,
   Jana/AAD-7261-2019; Dehghan, Abbas/B-9896-2008; Voortman,
   Trudy/C-2963-2015
OI Dehghan, Abbas/0000-0001-6403-016X; Franco, Oscar/0000-0002-4606-4929;
   Muka, Taulant/0000-0003-3235-3073; Cepeda-Gil,
   Magda/0000-0003-4579-6033; Dhana, Klodian/0000-0002-6397-7009; Voortman,
   Trudy/0000-0003-2830-6813
FU Erasmus Mundus Western Balkans (ERAWEB) project; European Commission;
   Metagenics, Inc.; NWO grant (Veni) [916.12.154]; EUR Fellowship
FX J. Nano, K. Dhana and A. Brahimaj have been financially supported by the
   Erasmus Mundus Western Balkans (ERAWEB) project, funded by the European
   Commission. T. Voortman and T. Muka have received research support from
   Metagenics, Inc. A. Dehghan is supported by an NWO grant (Veni no.
   916.12.154) and the EUR Fellowship. O.H. Franco has received grants and
   research support from Metagenics, Inc.
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NR 78
TC 49
Z9 51
U1 2
U2 11
PU MASSON EDITEUR
PI MOULINEAUX CEDEX 9
PA 21 STREET CAMILLE DESMOULINS, ISSY, 92789 MOULINEAUX CEDEX 9, FRANCE
SN 1262-3636
EI 1878-1780
J9 DIABETES METAB
JI Diabetes Metab.
PD DEC
PY 2016
VL 42
IS 6
BP 389
EP 397
DI 10.1016/j.diabet.2016.06.002
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA EH6SF
UT WOS:000391903500002
PM 27396752
DA 2025-06-11
ER

PT J
AU García-Mendizábal, MJ
   Carrasco, JM
   Pérez-Gómez, B
   Aragonés, N
   Gualler-Castillón, P
   Rodríguez-Artalejo, F
   López-Abente, G
   Pollán, M
AF Jose Garcia-Mendizabal, Maria
   Miguel Carrasco, Jose
   Perez-Gomez, Beatriz
   Aragones, Nuria
   Gualler-Castillon, Pilar
   Rodriguez-Artalejo, Fernando
   Lopez-Abente, Gonzalo
   Pollan, Marina
TI Role of educational level in the relationship between Body Mass Index
   (BMI) and health-related quality of life (HRQL) among rural Spanish
   women
SO BMC PUBLIC HEALTH
LA English
DT Article
ID SOCIOECONOMIC-STATUS; METABOLIC SYNDROME; CHRONIC ILLNESS;
   MENTAL-HEALTH; SURVEY SF-36; OBESITY; POPULATION; WEIGHT; PREVALENCE;
   OVERWEIGHT
AB Background: The impact of obesity on health-related quality of life (HRQL) has been little explored in rural areas. The goal of this study is to ascertain the association between obesity and HRQL among Spanish women living in a rural area, and the influence of their educational level.
   Methods: Cross-sectional study with personal interview of 1298 women (aged 18 to 60) randomly selected from the electoral rolls of 14 towns in Galicia, a region in the north-west of Spain. HRQL was assessed using the SF-36 questionnaire. The association between body mass index (BMI) and suboptimal scores in the different HRQL dimensions was summarised using odds ratios (ORs), obtained from multivariate logistic regression models. Separate analyses were conducted for women who had finished their education younger than 16 years old and women with secondary education to assess differences in the relationship between BMI and HRQL according to educational level.
   Results: Among women with primary or lower education, obesity was associated with a higher prevalence of suboptimal values in the following dimensions: Physical functioning (OR: 1.97; 95% CI: 1.22-3.18); Role-physical (OR: 1.81; 95% CI: 1.04-3.14); General health (OR: 1.76; 95% CI: 1.10-2.81); and Role-emotional (OR: 2.52; 95% CI: 1.27-5.03). In women with higher education, physical functioning was the only dimension associated with obesity (OR: 2.02: 95% CI 0.83-4.97).
   Conclusion: The impact of obesity on women's HRQL is greater among those with a lower educational level. This group registered higher prevalence of obesity and poorer self-perceived health.
C1 [Jose Garcia-Mendizabal, Maria; Miguel Carrasco, Jose; Perez-Gomez, Beatriz; Aragones, Nuria; Lopez-Abente, Gonzalo; Pollan, Marina] Carlos III Inst Hlth, Natl Ctr Epidemiol, Dept Environm Epidemiol & Canc, Madrid, Spain.
   [Miguel Carrasco, Jose] Aragon Hlth Sci Inst, Zaragoza, Spain.
   [Gualler-Castillon, Pilar; Rodriguez-Artalejo, Fernando] Univ Autonoma Madrid, Dept Prevent Med & Publ Hlth, Sch Med, Madrid, Spain.
C3 Instituto de Salud Carlos III; Autonomous University of Madrid
RP Carrasco, JM (corresponding author), Carlos III Inst Hlth, Natl Ctr Epidemiol, Dept Environm Epidemiol & Canc, Madrid, Spain.
EM mjota74@hotmail.com; jmcarrasco.iacs@aragon.es; bperez@isciii.es;
   naragones@isciii.es; mpilar.guallar@uam.es; fernando.artalejo@uam.es;
   glabente@isciii.es; mpollan@isciii.es
RI Carrasco, JosÃ©/I-3482-2015; Guallar-Castillon, Pilar/F-1533-2016;
   Lopez-Abente, Gonzalo/E-5221-2010; Perez-Gomez, Beatriz/C-4715-2012;
   Aragones, Nuria/O-5962-2015; Pollan, Marina/M-3259-2014
OI Aragones, Nuria/0000-0003-0983-2156; Pollan, Marina/0000-0002-4328-1565
FU Instituto de Salud Carlos III [001/05]
FX This study was funded by the Instituto de Salud Carlos III ( grant
   001/05).
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NR 50
TC 34
Z9 34
U1 0
U2 9
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1471-2458
J9 BMC PUBLIC HEALTH
JI BMC Public Health
PD APR 30
PY 2009
VL 9
AR 120
DI 10.1186/1471-2458-9-120
PG 10
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA 471UT
UT WOS:000268084500001
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Foley, KP
   Chen, Y
   Barra, NG
   Heal, M
   Kwok, K
   Tamrakar, AK
   Chi, W
   Duggan, BM
   Henriksbo, BD
   Liu, Y
   Schertzer, JD
AF Foley, Kevin P.
   Chen, Yong
   Barra, Nicole G.
   Heal, Mark
   Kwok, Kieran
   Tamrakar, Akhilesh K.
   Chi, Wendy
   Duggan, Brittany M.
   Henriksbo, Brandyn D.
   Liu, Yong
   Schertzer, Jonathan D.
TI Inflammation promotes adipocyte lipolysis via IRE1 kinase
SO JOURNAL OF BIOLOGICAL CHEMISTRY
LA English
DT Article
ID ENDOPLASMIC-RETICULUM STRESS; NECROSIS-FACTOR-ALPHA; SIGNAL-RELATED
   KINASE; INSULIN-RESISTANCE; ER STRESS; STIMULATES LIPOLYSIS; NOD1
   ACTIVATORS; LINKS OBESITY; CONTRIBUTE; IMMUNITY
AB Obesity associates with inflammation, insulin resistance, and higher blood lipids. It is unclear if immune responses facilitate lipid breakdown and release from adipocytes via lipolysis in a separate way from hormones or adrenergic signals. We found that an ancient component of ER stress, inositol-requiring protein 1 (IRE1), discriminates inflammation-induced adipocyte lipolysis versus lipolysis from adrenergic or hormonal stimuli. Our data show that inhibiting IRE1 kinase activity was sufficient to block adipocyte-autonomous lipolysis from multiple inflammatory ligands, including bacterial components, certain cytokines, and thapsigargin-induced ER stress. IRE1-mediated lipolysis was specific for inflammatory triggers since IRE1 kinase activity was dispensable for isoproterenol and cAMP-induced lipolysis in adipocytes and mouse adipose tissue. IRE1 RNase activity was not associated with inflammation-induced adipocyte lipolysis. Inhibiting IRE1 kinase activity blocked NF-kappa B activation, interleukin-6 secretion, and adipocyte-autonomous lipolysis from inflammatory ligands. Inflammation-induced lipolysis mediated by IRE1 occurred independently from changes in insulin signaling in adipocytes, suggesting that inflammation can promote IRE1-mediated lipolysis independent of adipocyte insulin resistance. We found no role for canonical unfolded protein responses or ABL kinases in linking ER stress to IRE1-mediated lipolysis. Adiponectin-Cre-mediated IRE1 knockout in mice showed that adipocyte IRE1 was required for inflammatory ligand-induced lipolysis in adipose tissue explants and that adipocyte IRE1 was required for approximately half of the increase in blood triglycerides after a bacterial endotoxin-mediated inflammatory stimulus in vivo. Together, our results show that IRE1 propagates an inflammation-specific lipolytic program independent from hormonal or adrenergic regulation. Targeting IRE1 kinase activity may benefit metabolic syndrome and inflammatory lipid disorders.
C1 [Foley, Kevin P.; Barra, Nicole G.; Heal, Mark; Kwok, Kieran; Tamrakar, Akhilesh K.; Chi, Wendy; Duggan, Brittany M.; Henriksbo, Brandyn D.; Schertzer, Jonathan D.] McMaster Univ, Farncombe Family Digest Hlth Res Inst, Dept Biochem & Biomed Sci, Hamilton, ON, Canada.
   [Foley, Kevin P.; Barra, Nicole G.; Heal, Mark; Kwok, Kieran; Tamrakar, Akhilesh K.; Chi, Wendy; Duggan, Brittany M.; Henriksbo, Brandyn D.; Schertzer, Jonathan D.] McMaster Univ, Ctr Metab Obes & Diabet Res, Hamilton, ON, Canada.
   [Chen, Yong; Liu, Yong] Wuhan Univ, Coll Life Sci, Inst Adv Studies, Hubei Key Lab Cell Homeostasis, Wuhan, Peoples R China.
   [Tamrakar, Akhilesh K.] CSIR Cent Drug Res Inst, Div Biochem, Lucknow, Uttar Pradesh, India.
C3 McMaster University; McMaster University; Wuhan University; Council of
   Scientific & Industrial Research (CSIR) - India; CSIR - Central Drug
   Research Institute (CDRI)
RP Schertzer, JD (corresponding author), McMaster Univ, Farncombe Family Digest Hlth Res Inst, Dept Biochem & Biomed Sci, Hamilton, ON, Canada.; Schertzer, JD (corresponding author), McMaster Univ, Ctr Metab Obes & Diabet Res, Hamilton, ON, Canada.
EM schertze@mcmaster.ca
RI Barra, Nicole/ABG-2670-2021; Schertzer, Jonathan/P-3395-2017
OI Schertzer, Jonathan/0000-0002-1547-5856; Tamrakar,
   Akhilesh/0000-0003-0554-3779; LIU, YONG/0000-0001-7771-4181; Chen,
   Yong/0000-0002-0723-8105
FU Canadian Institutes of Health Research [FDN-154295]; National Natural
   Science Foundation of China [31690102]; Indian Council of Medical
   Research, Govt. of India
FX This work was supported by grants to J. D. S. from the Canadian
   Institutes of Health Research (FDN-154295) and to Y. L. from the
   National Natural Science Foundation of China (No. 31690102). A. K. T.
   was supported by ICMR International Fellowship from the Indian Council
   of Medical Research, Govt. of India. J. D. S. holds a Canada Research
   Chair in Metabolic Inflammation.
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NR 51
TC 39
Z9 44
U1 0
U2 10
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
EI 1083-351X
J9 J BIOL CHEM
JI J. Biol. Chem.
PD JAN-JUN
PY 2021
VL 296
AR 100440
DI 10.1016/j.jbc.2021.100440
PG 15
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA TI5TQ
UT WOS:000672866400414
PM 33610548
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Lecca, LI
   Campagna, M
   Portoghese, I
   Galletta, M
   Mucci, N
   Meloni, M
   Cocco, P
AF Lecca, Luigi Isaia
   Campagna, Marcello
   Portoghese, Igor
   Galletta, Maura
   Mucci, Nicola
   Meloni, Michele
   Cocco, Pierluigi
TI Work Related Stress, Well-Being and Cardiovascular Risk among Flight
   Logistic Workers: An Observational Study
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Article
DE work-related stress; cardiovascular risk score; Karasek taxonomy;
   general well-being; tailored workplace health promotion
ID DEMAND-CONTROL-SUPPORT; JOB STRAIN; BLOOD-PRESSURE; AUTONOMIC IMBALANCE;
   METABOLIC SYNDROME; DISEASE; HEALTH; MODEL; CARE
AB Work-related stress is a known occupational hazard, with a putative role on the development of cardiovascular diseases (CVD). Although several investigations have explored the association in various workplace scenarios, none have focused on the airport flight logistic support personnel, a transportation business of crucial importance, potentially exposed to job stress and consequently to an increase in CVD risk. We explored the relationship between work-related stress and cardiovascular risk in 568 healthy workers of a flight logistic support company using the Health and Safety Executive questionnaire, the Framingham Heart Study General Cardiovascular Disease (CVD) Risk Prediction Score, and the WHO general well-being index (WHO-5). We used univariate and multivariate statistical methods to take account of possible confounders. Our results show that a low job support significantly increases the CVD risk score and decreases the WHO well-being index with reference to subjects reporting high support on the job. In addition, the well-being index of workers with high strain jobs appears lower in respect to workers employed in low strain job. The multivariate analysis confirms a protective effect of job support, and shows a detrimental influence on CVD risk by physical inactivity, regular intake of alcohol, and a low educational level. In addition, job control, job support, low strain, and high demand coupled with high control (active job) showed a beneficial effect on psychological well-being. Our results suggest that a combination of general risk factors and organizational factors contributes to increase CVD risk and well-being, representing a crucial target for intervention strategies to promote health in the workplace.
C1 [Lecca, Luigi Isaia; Campagna, Marcello; Portoghese, Igor; Galletta, Maura; Cocco, Pierluigi] Univ Cagliari, Dept Med Sci & Publ Hlth, SS 554,Km 4-500, I-09042 Monserrato, Italy.
   [Mucci, Nicola] Univ Florence, Dept Clin & Expt Med, I-50134 Florence, Italy.
   [Meloni, Michele] Univ Cagliari, CENTRALABS, Engn Labs, SS 554,Km 4-500, I-09042 Monserrato, Italy.
C3 University of Cagliari; University of Florence; University of Cagliari
RP Lecca, LI (corresponding author), Univ Cagliari, Dept Med Sci & Publ Hlth, SS 554,Km 4-500, I-09042 Monserrato, Italy.
EM isaialecca@gmail.com; mam.campagna@gmail.com; igor.portoghese@gmail.com;
   maura.galletta@gmail.com; nicola.mucci@unifi.it; mikke.049@gmail.com;
   pcocco@unica.it
RI Campagna, Marcello/L-1011-2016; Cocco, Pierluigi/AAM-7474-2021;
   Portoghese, Igor/A-5273-2011
OI Lecca, Luigi Isaia/0000-0001-8310-411X; Mucci,
   Nicola/0000-0003-0579-1035; Galletta, Maura/0000-0002-0124-4248;
   Portoghese, Igor/0000-0003-3700-8594
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NR 48
TC 33
Z9 37
U1 1
U2 11
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD SEP
PY 2018
VL 15
IS 9
AR 1952
DI 10.3390/ijerph15091952
PG 14
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA GV0PX
UT WOS:000445765600161
PM 30205457
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Ruano, C
   Henriquez, P
   Martínez-González, MA
   Bes-Rastrollo, M
   Ruiz-Canela, M
   Sánchez-Villegas, A
AF Ruano, Cristina
   Henriquez, Patricia
   Angel Martinez-Gonzalez, Miguel
   Bes-Rastrollo, Maira
   Ruiz-Canela, Miguel
   Sanchez-Villegas, Almudena
TI Empirically Derived Dietary Patterns and Health-Related Quality of Life
   in the SUN Project
SO PLOS ONE
LA English
DT Article
ID CORONARY-HEART-DISEASE; MEDITERRANEAN DIET; FATTY-ACIDS; DEPRESSIVE
   SYMPTOMS; NEUROTROPHIC FACTOR; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   GLYCEMIC INDEX; FAST-FOOD; RISK
AB Objective: The analysis of dietary patterns has become a valuable tool to examine diet-disease relationships but little is known about their effects on quality of life. Our aim was to ascertain the association between major dietary patterns and mental and physical quality of life after 4 years of follow-up.
   Materials and Methods: This analysis included 11,128 participants from the "Seguimiento Universidad de Navarra'' (SUN) cohort. Dietary habits were assessed using a validated food-frequency questionnaire. Factor analysis was used to derive dietary patterns. Quality of life was measured with the validated Spanish version of the SF-36 Health Survey.
   Results: Two major dietary patterns were identified, the 'Western' dietary pattern (rich in red meats, processed pastries and fast-food) and the "Mediterranean'' dietary pattern (high in fruits, vegetables and olive oil). After controlling for confounders, the Western dietary pattern was associated with quality of life in all domains. The magnitude of these differences between the subjects in the highest (quintile 5) and the lowest quintile of adherence to the Western pattern ranged from 20.8 (for mental health) to 23.5 (for vitality). On the contrary, the Mediterranean dietary pattern was associated with better quality of life domains: differences ranged from + 1.3 (for physical functioning) to + 3.4 (for vitality) when comparing extreme quintiles of adherence. Additional sensitivity analyses did not change the reported differences.
   Conclusions: Whereas baseline adherence to a Western dietary pattern was inversely associated with self-perceived quality of life after 4 years of follow-up, baseline adherence to a Mediterranean dietary pattern was directly associated with better scores in quality of life four years later in the SUN Project.
C1 [Ruano, Cristina; Henriquez, Patricia; Sanchez-Villegas, Almudena] Univ Las Palmas Gran Canaria, Dept Clin Sci, Las Palmas Gran Canaria, Spain.
   [Angel Martinez-Gonzalez, Miguel; Bes-Rastrollo, Maira; Ruiz-Canela, Miguel; Sanchez-Villegas, Almudena] Univ Navarra, Dept Prevent Med & Publ Hlth, E-31080 Pamplona, Spain.
   [Ruano, Cristina; Henriquez, Patricia; Angel Martinez-Gonzalez, Miguel; Sanchez-Villegas, Almudena] Inst Salud Carlos III, Ciber Fisiopatol Obesidad & Nutr, CIBEROBN, CB06 03, Madrid, Spain.
C3 Universidad de Las Palmas de Gran Canaria; University of Navarra; CIBER
   - Centro de Investigacion Biomedica en Red; CIBEROBN; Instituto de Salud
   Carlos III
RP Ruano, C (corresponding author), Univ Las Palmas Gran Canaria, Dept Clin Sci, Las Palmas Gran Canaria, Spain.
EM cruano@proyinves.ulpgc.es
RI Sanchez-Villegas, Almudena/T-6733-2019; Rodríguez, Patricia/H-5290-2015;
   Martínez-González, Marina/R-6165-2016; Martinez-Gonzalez,
   Miguel/AAE-7669-2019; Ruiz-Canela, Miguel/JYP-1794-2024; Stefanadis,
   Christodoulos/ABH-2232-2020; BES-RASTROLLO, MAIRA/A-1329-2009;
   Ruiz-Canela, Miguel/I-7738-2016
OI Sanchez Villegas, Almudena/0000-0001-7733-9238; Martinez-Gonzalez,
   Miguel A./0000-0002-3917-9808; Stefanadis,
   Christodoulos/0000-0001-5974-6454; BES-RASTROLLO,
   MAIRA/0000-0002-9139-4206; Ruiz-Canela, Miguel/0000-0002-7684-2787
FU Instituto de Salud Carlos III, Official Agency of the Spanish Government
   for biomedical research [PI01/0619, PI030678, PI040233, PI042241,
   PI050976, PI070240, PI070312, PI081943, PI080819, PI1002293, PI1002658,
   RD06/0045, G03/140]; Navarra Regional Government [36/2001, 43/2002,
   41/2005, 36/2008]
FX The SUN Project has received funding from Instituto de Salud Carlos III,
   Official Agency of the Spanish Government for biomedical research
   (Grants PI01/0619, PI030678, PI040233, PI042241, PI050976, PI070240,
   PI070312, PI081943, PI080819, PI1002293, PI1002658, RD06/0045, and
   G03/140), the Navarra Regional Government (36/2001, 43/2002, 41/2005 and
   36/2008) and the University of Navarra. The funders had no role in study
   design, data collection and analysis, decision to publish, or
   preparation of the manuscript.
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NR 64
TC 40
Z9 42
U1 0
U2 18
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAY 1
PY 2013
VL 8
IS 5
AR e61490
DI 10.1371/journal.pone.0061490
PG 10
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Science & Technology - Other Topics
GA 147KY
UT WOS:000319167000015
PM 23658694
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Rundblad, L
   Zwisler, AD
   Johansen, PP
   Holmberg, T
   Schneekloth, N
   Giraldi, A
AF Rundblad, Lucas
   Zwisler, Ann Dorthe
   Johansen, Pernille Palm
   Holmberg, Teresa
   Schneekloth, Nanna
   Giraldi, Annamaria
TI Perceived Sexual Difficulties and Sexual Counseling in Men and Women
   Across Heart Diagnoses: A Nationwide Cross-Sectional Study
SO JOURNAL OF SEXUAL MEDICINE
LA English
DT Article
DE Sexual Dysfunctions; Atrial Fibrillation; Heart Failure; Myocardial
   Infarction; Ischemic Heart Disease; Heart Valve Disease; Sexual
   Counseling; Cardiovascular Agents
ID 4TH INTERNATIONAL CONSULTATION; ACUTE MYOCARDIAL-INFARCTION;
   QUALITY-OF-LIFE; ERECTILE DYSFUNCTION; CARDIOVASCULAR-DISEASE;
   CARDIOMETABOLIC RISK; CONSENSUS STATEMENT; ATRIAL-FIBRILLATION;
   UNITED-STATES; PREVALENCE
AB Background: Ischemic heart disease and heart failure often lead to sexual difficulties in men, but little is known about the sexual difficulties in women and patients with other heart diagnoses or the level of information patients receive about the risk of sexual difficulties.
   Aim: To investigate perceived sexual difficulties and associated factors in a mixed population of men and women newly diagnosed with heart disease and provide insight into sexual counseling and information given by health care professionals.
   Methods: This article reports on a cross-sectional, questionnaire study sent to a randomly selected sample of men and women newly diagnosed with heart failure, ischemic heart disease, atrial fibrillation, or heart valve surgery. Eligible patients were identified by diagnosis using the Danish National Patient Register, which contains all diagnoses.
   Outcomes: Sexual difficulties were self-reported using single-item questions, and factors associated with sexual difficulties were collected from the survey and national registers.
   Results: The study population consisted of 1,549 men and 807 women (35-98 years old) with heart failure (n = 243), ischemic heart disease (n = 1,036), heart valve surgery (n = 375), and atrial fibrillation (n = 702). Sexual difficulties were reported by 55% of men and 29% of women. In a multiple regression analysis, difficulties in men were associated with being older (>= 75 years old; odds ratio [OR] = 1.97, 95% CI = 1.13-3.43), having heart failure (OR = 2.07, 95% CI = 1.16-3.71), diabetes (OR = 1.80, 95% CI = 1.15-2.82), hypertension (OR = 1.43, 95% CI = 1.06-1.93), receiving beta-blockers (OR = 1.37, 95% CI = 1.02-1.86), or having anxiety (OR = 2.25, 95% CI = 1.34-3.80) or depression (OR = 2.74, 95% CI = 1.38-5.43). In women, difficulties were significantly associated with anxiety (OR = 3.00, 95% CI = 1.51-5.95). A total of 48.6% of men and 58.8% of women did not feel informed about sexuality, and 18.1% of men and 10.3% of women were offered sexual counseling.
   Clinical Implications: Heart disease increases the risk of sexual difficulties and there is a need for improved information and counseling about sex and relationships for patients.
   Strengths and Limitations: This large nationwide survey of men and women combined a survey with administrative data from national registries. However, this study used non-validated single-item questions to assess sexual difficulties without addressing sexual distress.
   Conclusion: More than half the men and one fourth the women across common heart diagnoses had sexual difficulties. No difference was found among diagnoses, except heart failure in men. Despite guidelines recommending sexual counseling, sexual difficulties were not met by sufficient information and counseling. Copyright (C) 2017, International Society for Sexual Medicine. Published by Elsevier Inc. All rights reserved.
C1 [Rundblad, Lucas; Holmberg, Teresa; Schneekloth, Nanna] Univ Southern Denmark, Natl Inst Publ Hlth, Copenhagen, Denmark.
   [Rundblad, Lucas; Zwisler, Ann Dorthe] Univ Southern Denmark, Danish Knowledge Ctr Rehabil & Palliat Care, Nyborg, Denmark.
   [Rundblad, Lucas; Zwisler, Ann Dorthe] Univ Hosp Odense, Nyborg, Denmark.
   [Rundblad, Lucas; Giraldi, Annamaria] Rigshosp, Sexol Clin, Psychiat Ctr Copenhagen, Copenhagen, Denmark.
   [Johansen, Pernille Palm] Rigshosp, Copenhagen Univ Hosp, Ctr Heart, Dept Cardiol, Copenhagen, Denmark.
   [Johansen, Pernille Palm] Copenhagen Univ Hosp Bispebjerg & Frederiksberg, Dept Cardiol, Copenhagen, Denmark.
   [Giraldi, Annamaria] Univ Copenhagen, Inst Clin Med, Copenhagen, Denmark.
C3 University of Southern Denmark; University of Southern Denmark;
   University of Southern Denmark; Odense University Hospital; University
   of Copenhagen; Copenhagen University Hospital; Rigshospitalet;
   Rigshospitalet; University of Copenhagen; Copenhagen University
   Hospital; University of Copenhagen; Bispebjerg Hospital; University of
   Copenhagen
RP Rundblad, L (corresponding author), Natl Inst Publ Hlth, Osterfarimagsgade 5A, DK-1353 Copenhagen K, Denmark.
EM lucasrundblad@gmail.com
RI Giraldi, Annamaria/AAW-6292-2020; Zwisler, Ann-Dorthe/F-1421-2015; Palm,
   Pernille/KHX-8272-2024; Schneekloth Jarlstrup, Nanna/JGC-7397-2023
OI Palm, Pernille/0000-0002-8437-5445; Schneekloth Jarlstrup,
   Nanna/0000-0003-1441-4151; Giraldi, Annamaria/0000-0002-0033-8517;
   Zwisler, Ann Dorthe Olsen/0000-0002-9241-2090
FU The Danish Heart Foundation
FX The Danish Heart Foundation.
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NR 44
TC 15
Z9 17
U1 1
U2 11
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1743-6095
EI 1743-6109
J9 J SEX MED
JI J. Sex. Med.
PD JUN
PY 2017
VL 14
IS 6
BP 785
EP 796
DI 10.1016/j.jsxm.2017.04.673
PG 12
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Urology & Nephrology
GA FA1DV
UT WOS:000405180400005
PM 28583340
DA 2025-06-11
ER

PT J
AU Arreola, EV
   Coonrod, DV
   Choudhury, SR
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   Hoskin, M
   Wasak, D
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AF Arreola, Elsa Vazquez
   Coonrod, Dean V.
   Roy Choudhury, Sourav
   Knowler, William C.
   Hoskin, Mary
   Wasak, Dorota
   Williams, Rachel
   Hanson, Robert L.
   Pack, Elena
   Caballero, Rachel
   Gonzalez, Amanda
   Sinha, Madhumita
TI Study protocol for Early Tracking of Childhood Health determinants
   (ETCHED): A longitudinal observational life course study
SO BMC PUBLIC HEALTH
LA English
DT Article
DE Childhood obesity; Minority health; Gestational diabetes; Youth onset
   diabetes
ID DEPENDENT DIABETES-MELLITUS; RISK-FACTORS; OBESITY; YOUTH
AB BackgroundThe prevalence of childhood obesity and diabetes continues to rise in the United States (US), especially among minority populations. The objective of the Early Tracking of Childhood Health Determinants (ETCHED) study is to investigate the role of adverse fetal and early-life risk exposures that contribute to the development of childhood obesity and metabolic risk.MethodsETCHED is a longitudinal observational study of American Indian/Alaska Native (AI/AN) and Hispanic pregnant woman and their offspring. Pregnant mothers >= 18 years old are enrolled at a large public hospital system in the southwestern US. Enrolled mothers are followed through pregnancy, delivery, and the maternal/offspring dyad will be followed until the child's 18th birthday. At each maternal visit, questionnaires assessing medical history, diet, physical activity, sleep, perceived stress, and socioeconomic and sociocultural information are obtained. Standard laboratory tests during maternal visits include glycemic measures, lipids, and renal function. Additional bio samples obtained include venous blood samples and cord blood for obesity/metabolic biomarkers and genetic/epigenetic testing, urinalysis, placental tissue for examining functional pathways, breast milk for metabolomics, and stool for metabolites and microbiome analysis. The offspring will have 6 infant/toddler visits at 6-12 weeks, 4 months, 6 months, 18 months, 2 and 3 years respectively. Thereafter, they will undergo comprehensive research visits (major visits) at 4-5 years, 6-9 years, 10-13 years, and 14-17 years. The major visits in children include detailed medical history, anthropometry, developmental assessment, socioeconomic and environmental assessments (food insecurity, family structure, and childcare), feeding and activity, biochemical tests, genetics/epigenetic testing, and ultrasound elastography. Electronic health records will be reviewed for additional clinical information. The primary analysis will constitute estimation of correlation coefficients between continuous variables. The planned study duration in this ongoing study is 23-years.DiscussionThis is a life course study that that will examine biological and environmental risk factors for obesity and cardiometabolic risk from the intrauterine period to early childhood and adolescence in a population with high-risk of obesity and type 2 diabetes in the United States. The ETCHED study would also provide a unique opportunity to combine multi-omics and clinical data to create novel integrative models to predict the cardiometabolic risk associated with childhood obesity and possibly identify etiopathogenetic mechanisms and future targets of intervention.Trial registration numberClinicalTrials.gov identifier: NCT03481829. Updated July 19, 2024, https://clinicaltrials.gov/study/NCT03481829?cond=ETCHED&rank=1.
C1 [Roy Choudhury, Sourav; Wasak, Dorota; Williams, Rachel; Pack, Elena; Caballero, Rachel; Gonzalez, Amanda; Sinha, Madhumita] Natl Inst Diabet & Digest & Kidney Dis NIDDK, Diabet Epidemiol & Clin Res Sect, Phoenix, AZ 20892 USA.
   [Coonrod, Dean V.] Valleywise Hlth Med Ctr, Dept Obstet & Gynecol, Phoenix, AZ USA.
   [Coonrod, Dean V.] Univ Sch Med Phoenix Reg Campus, Affiliate Fac Creighton, Dept Obstet & Gynecol, Phoenix, AZ USA.
   [Arreola, Elsa Vazquez; Roy Choudhury, Sourav; Knowler, William C.; Hoskin, Mary; Wasak, Dorota; Williams, Rachel; Hanson, Robert L.; Pack, Elena; Caballero, Rachel; Gonzalez, Amanda; Sinha, Madhumita] Natl Inst Diabet & Digest & Kidney Dis NIDDK, NIH, Phoenix Epidemiol & Clin Res Branch PECRB, 1550 E Indian Sch Rd, Phoenix, AZ 85014 USA.
C3 National Institutes of Health (NIH) - USA
RP Sinha, M (corresponding author), Natl Inst Diabet & Digest & Kidney Dis NIDDK, Diabet Epidemiol & Clin Res Sect, Phoenix, AZ 20892 USA.; Sinha, M (corresponding author), Natl Inst Diabet & Digest & Kidney Dis NIDDK, NIH, Phoenix Epidemiol & Clin Res Branch PECRB, 1550 E Indian Sch Rd, Phoenix, AZ 85014 USA.
EM Madhumita.Sinha@nih.gov
FU National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
FX The authors wish to thank the study patients for their participation and
   the clinical and nursing staff in the Obstetrics and Gynecology,
   Pediatrics, and Research Departments at Valleywise Health for
   facilitating the study.
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NR 20
TC 0
Z9 0
U1 2
U2 5
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2458
J9 BMC PUBLIC HEALTH
JI BMC Public Health
PD SEP 29
PY 2024
VL 24
IS 1
AR 2661
DI 10.1186/s12889-024-20176-7
PG 8
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA H6E2A
UT WOS:001324342900001
PM 39343891
OA gold
DA 2025-06-11
ER

PT J
AU Zheng, XL
   Lu, JM
   Xiang, SJ
   Zou, P
   Chen, H
   Liu, J
   Zeng, C
   He, YH
AF Zheng, Xialei
   Lu, Junmi
   Xiang, Shaojun
   Zou, Pu
   Chen, Hao
   Liu, Jing
   Zeng, Cheng
   He, Yuhu
TI Elevated serum levels of leukocyte cell-derived chemotaxin 2 are
   associated with the prevalence of metabolic syndrome
SO ACTA DIABETOLOGICA
LA English
DT Article
DE LECT2; Metabolic syndrome; Inflammation
ID ISOLATED SYSTOLIC HYPERTENSION; LECT2; OBESITY; INFILTRATION;
   PURIFICATION; INFLAMMATION; POLYMORPHISM; POPULATION; TRENDS; LINK
AB Aims Inflammation is central to the pathogenesis of metabolic syndrome (MetS). Leukocyte cell-derived chemotaxin 2 (LECT2) is constitutively secreted in response to inflammatory stimuli and oxidative stress contributing to tissue or systemic inflammation. We explored the relationship between LECT2 levels and MetS severity in humans and mice. Methods Serum LECT2 levels were measured in 210 participants with MetS and 114 without MetS (non-MetS). LECT2 expression in the liver and adipose tissue was also examined in mice fed a high-fat diet (HFD) and genetically obese (ob/ob) mice. Results Serum LECT2 levels were significantly higher in MetS participants than in non-MetS participants (7.47[3.36-17.14] vs. 3.74[2.61-5.82], P < 0.001). Particularly, serum LECT2 levels were significantly elevated in participants with hypertension, central obesity, diabetes mellitus (DM), hyperglycaemia, elevated triglyceride (TG) levels, and reduced high-density lipoprotein cholesterol (HDL-C) levels compared to those in participants without these conditions. Pearson's correlation analysis showed that serum LECT2 levels were positively associated with conventional risk factors in all patients. Moreover, LECT2 was positively associated with the number of MetS components (r = 0.355, P < 0.001), indicating that higher serum LECT2 levels reflected MetS severity. Multivariate regression analysis revealed that a one standard deviation increase in LECT2 was associated with an odds ratio of 1.52 (1.01-2.29, P = 0.044) for MetS prevalence after adjusting for age, sex, body mass index, waist circumference, smoking status, white blood cell count, fasting blood glucose, TG, total cholesterol, HDL-C, blood urea nitrogen, and alanine aminotransferase. Receiver operating characteristic curve analysis confirmed the strong predictive ability of serum LECT2 levels for MetS. The optimum serum LECT2 cut-off value was 9.05. The area under the curve was 0.73 (95% confidence interval 0.68-0.78, P < 0.001), with a sensitivity and specificity of 45.71% and 95.61%, respectively. Additionally, LECT2 expression levels were higher at baseline and dramatically enhanced in metabolic organs (e.g. the liver) and adipose tissue in HFD-induced obese mice and ob/ob mice. Conclusions Increased LECT2 levels were significantly and independently associated with the presence and severity of MetS, indicating that LECT2 could be used as a novel biomarker and clinical predictor of MetS.
C1 [Zheng, Xialei; Zou, Pu; Liu, Jing; Zeng, Cheng; He, Yuhu] Cent South Univ, Xiangya Hosp 2, Dept Cardiol, Changsha 410011, Hunan, Peoples R China.
   [Lu, Junmi] Cent South Univ, Xiangya Hosp 2, Dept Pathol, Changsha 410011, Hunan, Peoples R China.
   [Xiang, Shaojun] Hong Jiang Hosp Tradit Chinese Med, Dept Cardiol, Huaihua 418200, Hunan, Peoples R China.
   [Chen, Hao] Univ South China, Dept Cardiol, Affiliated Hosp 2, Hengyang 421200, Hunan, Peoples R China.
C3 Central South University; Central South University; University of South
   China
RP He, YH (corresponding author), Cent South Univ, Xiangya Hosp 2, Dept Cardiol, Changsha 410011, Hunan, Peoples R China.
EM heyuhu1986@126.com
FU National Natural Science Foundation of China
FX Not applicable.
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NR 52
TC 1
Z9 1
U1 4
U2 7
PU SPRINGER-VERLAG ITALIA SRL
PI MILAN
PA VIA DECEMBRIO, 28, MILAN, 20137, ITALY
SN 0940-5429
EI 1432-5233
J9 ACTA DIABETOL
JI Acta Diabetol.
PD MAY
PY 2024
VL 61
IS 5
BP 643
EP 655
DI 10.1007/s00592-024-02242-z
EA FEB 2024
PG 13
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA UI6E5
UT WOS:001172666900001
PM 38383671
DA 2025-06-11
ER

PT J
AU Shad, MU
AF Shad, Mujeeb U. U.
TI Seventy Years of Antipsychotic Development: A Critical Review
SO BIOMEDICINES
LA English
DT Review
DE seventy; years; antipsychotic; development; critical; review
ID MAJOR DEPRESSIVE DISORDER; DOPAMINE SYSTEM STABILIZERS; LONG-ACTING
   INJECTION; DOUBLE-BLIND; ATYPICAL ANTIPSYCHOTICS; RESISTANT
   SCHIZOPHRENIA; METABOLIC SYNDROME; CLINICAL-PRACTICE; DRUG-INTERACTIONS;
   NEXT-GENERATION
AB Since the mid-1950s discovery of the first effective antipsychotic medications (APM), we have only been able to improve the tolerability but not the overall efficacy of currently available APMs, as reflected by effectiveness trials in Europe and the United States. This inability to develop more effective APMs is attributable to multiple factors, including failure to create and use assessment tools to assess core symptom domains in schizophrenia, move beyond the dopaminergic hypothesis and to develop "me too" drugs, imposing ill-defined research domain criteria, and lacking federal funding for clinical trials. The classification of APMs is also confusing, including second-generation, partial agonists, and multimodal APMs in the same class of APMs, despite significant differences in their mechanisms of action. Other factors stagnating drug development include inadequate sample sizes to address heterogeneity, lack of statistical measures correlating with clinical significance, using the atheoretical basis of psychiatric diagnoses, failure to control placebo response, and high cost of newer and perhaps more tolerable APMs. Furthermore, there has been a failure to develop early predictors of antipsychotic response and various tools to optimize an APM response. Finally, some mental health providers are also responsible for the suboptimal use of APMs, by using excessive maintenance doses, often with irrational polypharmacy, further compromising effectiveness and medication adherence. However, some bright spots in antipsychotic development include improved tolerability of APMs and long-acting injectables to address the high prevalence of medication nonadherence. This review critically reviews 70 years of antipsychotic development, the reasons behind the failure to develop more effective APMs, and suggestions for future direction.
C1 [Shad, Mujeeb U. U.] Univ Nevada, UNLV Sch Med, Las Vegas, NV 89154 USA.
   [Shad, Mujeeb U. U.] Touro Univ Nevada, Coll Osteopath Med, Las Vegas, NV 89014 USA.
   [Shad, Mujeeb U. U.] Valley Hlth Syst, Grad Med Educ, Psychiat Residency Program, Las Vegas, NV 89118 USA.
C3 Nevada System of Higher Education (NSHE); University of Nevada Las Vegas
RP Shad, MU (corresponding author), Univ Nevada, UNLV Sch Med, Las Vegas, NV 89154 USA.; Shad, MU (corresponding author), Touro Univ Nevada, Coll Osteopath Med, Las Vegas, NV 89014 USA.; Shad, MU (corresponding author), Valley Hlth Syst, Grad Med Educ, Psychiat Residency Program, Las Vegas, NV 89118 USA.
EM mujeebushad@gmail.com
RI Shad, Mujeeb/GRY-0012-2022
OI Shad, Mujeeb/0000-0002-5136-9452
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NR 134
TC 9
Z9 9
U1 0
U2 15
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2227-9059
J9 BIOMEDICINES
JI Biomedicines
PD JAN
PY 2023
VL 11
IS 1
AR 130
DI 10.3390/biomedicines11010130
PG 18
WC Biochemistry & Molecular Biology; Medicine, Research & Experimental;
   Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Research & Experimental Medicine;
   Pharmacology & Pharmacy
GA 7X8TM
UT WOS:000914467600001
PM 36672638
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Haaramo, P
   Rahkonen, O
   Hublin, C
   Laatikainen, T
   Lahelma, E
   Lallukka, T
AF Haaramo, Peija
   Rahkonen, Ossi
   Hublin, Christer
   Laatikainen, Tiina
   Lahelma, Eero
   Lallukka, Tea
TI Insomnia symptoms and subsequent cardiovascular medication: a
   register-linked follow-up study among middle-aged employees
SO JOURNAL OF SLEEP RESEARCH
LA English
DT Article
DE cardiovascular disease; dyslipidaemia; follow-up study; hypertension;
   insomnia; register data
ID REPORTED SLEEP PROBLEMS; INCIDENT HYPERTENSION; METABOLIC SYNDROME;
   RISK-FACTORS; MEN; DISEASE; COHORT; WOMEN; TIME; PREDICTOR
AB Sleep disturbances have been associated with an increased risk of cardiovascular disease outcomes. The associations of insomnia with hypertension and dyslipidaemia, the main modifiable cardiovascular risk factors, are less studied. We especially lack understanding on the longitudinal effects of insomnia on dyslipidaemia. We aimed to examine the associations of insomnia symptoms with subsequent prescribed medication for hypertension and dyslipidaemia using objective register-based follow-up data. Baseline questionnaire surveys among 40-60-year-old employees of the City of Helsinki, Finland, were conducted in 2000-2002 (n=6477, response rate 67%, 78% women) and linked to a national register on prescribed reimbursed medication 5-7years prior to and 5years after baseline. Associations between the frequency of insomnia symptoms (difficulties in initiating and maintaining sleep, non-restorative sleep) and hypertension and dyslipidaemia medication during the follow-up were analysed using logistic regression analysis (odds ratios with 95% confidence intervals). Analyses were adjusted for pre-baseline medication, sociodemographic and work-related factors, health behaviours, mental health, and diabetes. Frequent insomnia symptoms were reported by 20%. During the 5-year follow-up, 32% had hypertension medication and 15% dyslipidaemia medication. Adjusting for age, gender and pre-baseline medication, frequent insomnia symptoms were associated with hypertension medication (odds ratio 1.57, 95% confidence interval 1.23-2.00) and dyslipidaemia medication (odds ratio 1.59, 95% confidence interval 1.19-2.12). Occasional insomnia symptoms were also associated with cardiovascular medication, though less strongly. Further adjustments had negligible effects. To conclude, insomnia should be taken into account in the prevention and management of cardiovascular disease and related risk factors.
C1 [Haaramo, Peija; Rahkonen, Ossi; Lahelma, Eero; Lallukka, Tea] Univ Helsinki, Dept Publ Hlth, Hjelt Inst, FIN-00014 Helsinki, Finland.
   [Hublin, Christer; Lallukka, Tea] Finnish Inst Occupat Hlth, Helsinki, Finland.
   [Laatikainen, Tiina] Univ Eastern Finland, Fac Hlth Sci, Inst Publ Hlth & Clin Nutr, Kuopio, Finland.
   [Laatikainen, Tiina] Natl Inst Hlth & Welf, Dept Chron Dis Prevent, Helsinki, Finland.
   [Laatikainen, Tiina] Hosp Dist North Karelia, Joensuu, Finland.
C3 University of Helsinki; Finnish Institute of Occupational Health;
   University of Eastern Finland; Finland National Institute for Health &
   Welfare
RP Haaramo, P (corresponding author), Univ Helsinki, Dept Publ Hlth, Hjelt Inst, POB 41,Mannerheimintie 172, FIN-00014 Helsinki, Finland.
EM peija.haaramo@helsinki.fi
RI Hublin, Christer/AAM-7105-2021; Lalloo, Ratilal/O-5624-2014;
   Laatikainen, Tiina/ABD-6622-2021; Lahelma, Eero/ABC-8716-2020
OI Lahelma, Eero/0000-0002-1064-1333; Laatikainen,
   Tiina/0000-0002-6614-4782; Lallukka, Tea/0000-0003-3841-3129; Rahkonen,
   Ossi/0000-0002-7202-3274
FU Academy of Finland [1129225, 1257362]; Finnish Work Environment Fund;
   Juho Vainio Foundation; Emil Aaltonen Foundation; Doctoral Programs in
   Public Health
FX This work was supported by the Academy of Finland (grant numbers
   1129225, 1257362); the Finnish Work Environment Fund; the Juho Vainio
   Foundation; the Emil Aaltonen Foundation to P. H.; and the Doctoral
   Programs in Public Health to P.H.
CR [Anonymous], 2011, GUID ATC CLASS DDD A
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NR 36
TC 20
Z9 25
U1 0
U2 10
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0962-1105
EI 1365-2869
J9 J SLEEP RES
JI J. Sleep Res.
PD JUN
PY 2014
VL 23
IS 3
BP 281
EP 289
DI 10.1111/jsr.12116
PG 9
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA AH8HZ
UT WOS:000336379700007
PM 24313664
DA 2025-06-11
ER

PT J
AU Marucci, S
   Almerighi, G
   Cerutti, N
   Corbo, F
   Zupo, R
   De Iaco, G
   Lisco, G
   Triggiani, V
   De Pergola, G
AF Marucci, Simonetta
   Almerighi, Guido
   Cerutti, Nadia
   Corbo, Filomena
   Zupo, Roberta
   De Iaco, Giulia
   Lisco, Giuseppe
   Triggiani, Vincenzo
   De Pergola, Giovanni
TI Eating Disorders in the Time of the COVID-19 Pandemic: A Perspective
SO ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS
LA English
DT Article
DE Sars-cov-2; COVID-19; pandemic; eating disorders; anorexia nervosa;
   obesity
ID ANOREXIA-NERVOSA; METAANALYSIS; MORTALITY; PROFILE; RISK
AB Background: Due to the COVID-19 pandemic, current epidemiological conditions may exacerbate the risk of new-onset, recurrence and relapse of eating disorders. This perspective aims to better analyse the phenomenon.Results: Some data suggest that new-onset and recurrence/relapse of eating disorders are increasing due to the pandemic. Government restrictions, self-confinement, social isolation, restriction to healthcare facilities access, delayed access to diagnosis and cure, fear of contagion, distress and difficulties related to the telemedicine approach contribute to this burden. The Immune system dysfunction usually observed in undernourishment (e.g., anorexia nervosa) could delay the diagnosis of respiratory infections, including COVID-19, and predispose to possible bacterial superinfections. Conversely, patients with binge eating, obesity or metabolic syndrome are susceptible to high-grade systemic inflammation and poor prognosis once the infection has occurred.Discussion: More detailed data combining research on eating disorders and COVID-19 are required despite some evidence. Many data show that telemedicine has beneficial aspects, but its impact on long-term mental health is still poorly understood. Short- and long-term consequences of COVID-19 in patients with eating disorders are unknown, but they will likely become more apparent over time.Conclusion: Working on emotion regulating strategies in a post-pandemic world, when people have inadequate control over the background of negative emotions, could be a future treatment strategy. Long-term studies with a larger sample size are essential to assess the long-term consequences of the blockade on patients and their healthcare providers and identify useful strategies to improve clinical management.
C1 [Marucci, Simonetta; De Iaco, Giulia] Univ Campus Biomed, Dip Sci & Tecnol Uomo & Ambiente, Via Alvaro Portillo 21, Rome, Italy.
   [Almerighi, Guido] Azienda Osped G Brotzu, Ctr Malattie Dismetab & Arteriosclerosi, Cagliari, Italy.
   [Cerutti, Nadia] ASST Pavia, Med & Dietet Unit, Pavia, Italy.
   [Corbo, Filomena] Univ Bari Aldo Moro, Dept Pharm Drug Sci, Bari, Italy.
   [Zupo, Roberta; De Pergola, Giovanni] Natl Inst Gastroenterol, Res Hosp, Saverio Bellis, Bari, Italy.
   [Lisco, Giuseppe; Triggiani, Vincenzo] Univ Bari Aldo Moro, Sch Med, Interdisciplinary Dept Med, Sect Internal Med Geriatr Endocrinol & Rare Dis, Piazza Giulio Cesare 11, I-70124 Bari, Italy.
   [De Pergola, Giovanni] Univ Bari, Sch Med, Dept Internal Med & Clin Oncol, Clin Nutr Unit,Sch Med, Piazza Giulio Cesare 11, I-70124 Bari, Italy.
C3 University Campus Bio-Medico - Rome Italy; Universita degli Studi di
   Bari Aldo Moro; IRCCS Saverio de Bellis; Universita degli Studi di Bari
   Aldo Moro; Universita degli Studi di Bari Aldo Moro
RP Marucci, S (corresponding author), Univ Campus Biomed, Dip Sci & Tecnol Uomo & Ambiente, Via Alvaro Portillo 21, Rome, Italy.
EM simonetta.marucci@gmail.com
RI Lisco, Giuseppe/AAM-2388-2020; TRIGGIANI, VINCENZO/GSE-3588-2022; Zupo,
   Roberta/GPT-3724-2022; De Pergola, Giovanni/AAL-9999-2020; Corbo,
   Filomena/K-8409-2016
OI Zupo, Roberta/0000-0001-9885-1185; Corbo, Filomena/0000-0002-6951-1103;
   LISCO, GIUSEPPE/0000-0001-6521-8578; DE PERGOLA,
   Giovanni/0000-0003-0020-3273
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NR 52
TC 2
Z9 2
U1 0
U2 3
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1871-5303
EI 2212-3873
J9 ENDOCR METAB IMMUNE
JI Endocr. Metab. Immune Disord.-Drug Targets
PY 2023
VL 23
IS 2
BP 123
EP 128
DI 10.2174/1871530322666220422104009
PG 6
WC Endocrinology & Metabolism; Immunology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Immunology; Pharmacology & Pharmacy
GA A7XP9
UT WOS:000957215500001
PM 35466887
DA 2025-06-11
ER

PT J
AU Collins, E
   Tranter, S
   Irvine, F
AF Collins, E.
   Tranter, S.
   Irvine, F.
TI The physical health of the seriously mentally ill: an overview of the
   literature
SO JOURNAL OF PSYCHIATRIC AND MENTAL HEALTH NURSING
LA English
DT Article
DE barriers; causes; education; interventions; physical health; serious
   mental illness
ID INDUCED WEIGHT-GAIN; METABOLIC SYNDROME; EXCESS MORTALITY;
   SCHIZOPHRENIA; PROGRAM; PEOPLE; ILLNESS; ADULTS; INTERVENTION;
   ASSOCIATION
AB Accessible summary Individuals with serious mental ill health suffer excessive physical illness. The causes of physical illness amongst the seriously mentally ill are complex and multifaceted. There is limited empirical evidence to support the current emphasis on physical health assessment and health promotion for the seriously mentally ill. More robust research studies are needed to facilitate Evidence Based Practice in this area. Abstract Despite the wealth of literature which attests to the relationship between serious mental illness (SMI) and physical ill health, the provision of optimum physical health care for mental health service users remains a challenge. In England the Department of Health has identified the evident health inequalities for people with SMI as a priority area for health improvement, publishing numerous policy directives aimed at addressing these inequalities. However, this is a highly complex process and little is known about why the rhetoric of holistic health care has proved unattainable thus far. In this paper we present an informed commentary of the contemporary literature with the aim of offering a more comprehensive understanding of the health inequalities faced by people with SMI. We searched relevant databases for publications related to: the causes of poor physical health among the mentally ill, strategies to address these health needs and the impact which professional education, culture and services structure has on this facet of service delivery. This enabled us to identify potential strategies that can be adopted by health care practitioners wishing to improve the health of this vulnerable group, and by educationalists to advance professionals' knowledge of this important and ostensibly neglected area.
C1 [Collins, E.] Univ Chester, Fac Hlth & Social Care, Wirral CH63 4JY, Merseyside, England.
   [Tranter, S.] Bangor Univ, Sch Healthcare Sci, Bangor, Gwynedd, Wales.
   [Irvine, F.] Staffordshire Univ, Fac Hlth, Stoke On Trent ST4 2DE, Staffs, England.
C3 Bangor University; Staffordshire University
RP Collins, E (corresponding author), Univ Chester, Fac Hlth & Social Care, Clatterbridge Hosp, Clatterbridge Rd, Wirral CH63 4JY, Merseyside, England.
EM e.collins@chester.ac.uk
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NR 89
TC 34
Z9 38
U1 0
U2 28
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1351-0126
EI 1365-2850
J9 J PSYCHIATR MENT HLT
JI J. Psychiatr. Ment. Health Nurs.
PD SEP
PY 2012
VL 19
IS 7
BP 638
EP 646
DI 10.1111/j.1365-2850.2011.01831.x
PG 9
WC Nursing; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Psychiatry
GA 979XI
UT WOS:000306856600009
PM 22070657
DA 2025-06-11
ER

PT J
AU Liang, KW
   Lee, WJ
   Lee, IT
   Lee, WL
   Lin, SY
   Hsu, SL
   Wan, CJ
   Yu, CY
   Tsai, IC
   Fu, CP
   Ting, CT
   Sheu, WHH
AF Liang, Kae-Woei
   Lee, Wen-Jane
   Lee, I. -Te
   Lee, Wen-Lieng
   Lin, Shih-Yi
   Hsu, Shih-Lan
   Wan, Chu-Jen
   Yu, Chen-Yuan
   Tsai, I. -Chen
   Fu, Chia-Po
   Ting, Chih-Tai
   Sheu, Wayne H. -H.
TI Persistent elevation of paraoxonase-1 specific enzyme activity after
   weight reduction in obese non-diabetic men with metabolic syndrome
SO CLINICA CHIMICA ACTA
LA English
DT Article
DE Adiponectin; Metabolic syndrome; Obesity; Monocyte chemotactic protein-1
   (MCP-1); Paraoxonase-1 (PON1); Weight loss
ID CORONARY-HEART-DISEASE; SERUM PARAOXONASE; CARDIOVASCULAR-DISEASE;
   OXIDATIVE STRESS; ARYLESTERASE ACTIVITIES; ADIPONECTIN; RISK; PON1;
   INTERVENTION; OVERWEIGHT
AB Background: Paraoxonase-1 (PON1) is an esterase associated with the high-density lipoprotein (HDL) in serum. To date, there have been few reports about circulating PON1 protein concentration and specific activity in subjects with metabolic syndrome (MetS). More importantly, it is unknown whether weight loss could alter PON1 protein expression or specific activity in obese non-diabetic men with MetS.
   Methods: We prospectively enrolled a total of 40 obese non-diabetic men with MetS. Among them, 22 subjects finished the 3-month course of weight loss program and complied for longer follow-ups post-weight loss at the 3rd, 12th, and 18th month from the beginning of the program. Twenty-six healthy volunteers served as controls. Serum circulating PON1 concentration was measured by an enzyme linked immunosorbent kit (ELISA) and PON1 activity was measured by an automated PON1 activity assay.
   Results: Obese non-diabetic men with MetS (n = 40) had a higher PON1 protein concentration (31.0 +/- 11.3 vs. 24.8 +/- 9.7 mu g/ml, p = 0.025) but lower specific enzyme activity (7.5 +/- 4.0 vs. 11.2 +/- 7.2 mU/mu g, p = 0.023) than those of the controls. Multivariate regression analysis of baseline PON1 specific activity revealed that adiponectin was a significant positive predictor (p = 0.044) while monocyte chemotactic protein-1 (MCP-1) was a negative predictor (p = 0.031). After a 3-month weight loss program, obese MetS men (n = 22) had a significant weight reduction (95.8 +/- 9.0 to 86.3 +/- 10.4 kg, with a 9.9 +/- 5.4% decrease, p < 0.001). PON1 protein decreased significantly after weight loss and kept declining through the 3rd month till the 18th month follow-up. PON1 specific enzyme activity (baseline 7.5 +/- 2.6 mU/mu g) increased significantly after weight loss and kept increasing through the 12th month till the 18th month follow-ups (11.8 +/- 6.4 mU/mu g, p = 0.001 vs. baseline).
   Conclusions: Weight loss by a 3-month diet and exercise program time-sequentially increased PON1 specific enzyme activity in obese non-diabetic men with MetS. (C) 2011 Elsevier B.V. All rights reserved.
C1 [Lee, I. -Te; Lin, Shih-Yi; Fu, Chia-Po; Sheu, Wayne H. -H.] Taichung Vet Gen Hosp, Dept Med, Div Endocrinol & Metab, Taichung 407, Taiwan.
   [Liang, Kae-Woei; Lee, Wen-Lieng; Ting, Chih-Tai] Taichung Vet Gen Hosp, Ctr Cardiovasc, Taichung 407, Taiwan.
   [Liang, Kae-Woei; Lee, I. -Te; Lee, Wen-Lieng; Lin, Shih-Yi; Tsai, I. -Chen; Ting, Chih-Tai; Sheu, Wayne H. -H.] Natl Yang Ming Univ, Sch Med, Cardiovasc Res Ctr, Inst Clin Med, Taipei 112, Taiwan.
   [Liang, Kae-Woei; Lee, I. -Te; Lee, Wen-Lieng; Lin, Shih-Yi; Tsai, I. -Chen; Ting, Chih-Tai; Sheu, Wayne H. -H.] Natl Yang Ming Univ, Sch Med, Dept Med, Taipei 112, Taiwan.
   [Lee, Wen-Jane; Hsu, Shih-Lan; Yu, Chen-Yuan] Taichung Vet Gen Hosp, Dept Med Res, Taichung 407, Taiwan.
   [Lee, I. -Te; Sheu, Wayne H. -H.] Chung Shan Med Univ, Dept Med, Taichung, Taiwan.
   [Lee, Wen-Jane] Tunghai Univ, Taichung, Taiwan.
   [Wan, Chu-Jen] Taichung Vet Gen Hosp, Dept Food & Nutr, Taichung 407, Taiwan.
   [Tsai, I. -Chen] Taichung Vet Gen Hosp, Dept Radiol, Taichung 407, Taiwan.
   [Sheu, Wayne H. -H.] Natl Chung Hsing Univ, Inst Med Technol, Taichung 40227, Taiwan.
C3 Taichung Veterans General Hospital; Taichung Veterans General Hospital;
   National Yang Ming Chiao Tung University; National Yang Ming Chiao Tung
   University; Taichung Veterans General Hospital; Chung Shan Medical
   University; Tunghai University; Taichung Veterans General Hospital;
   Taichung Veterans General Hospital; National Chung Hsing University
RP Sheu, WHH (corresponding author), Taichung Vet Gen Hosp, Dept Med, Div Endocrinol & Metab, 160,Sec 3,Chung Kang Rd, Taichung 407, Taiwan.
EM whhsheu@vghtc.gov.tw
OI Lee, I-Te/0000-0003-2665-3635
FU Yen Tjing Ling Medical Foundation, Taiwan [CI-98-15]; Taichung Veterans
   General Hospital, Taiwan [TCVGH-993102B, 983103B, 973102B, 973504D,
   973111D, 973002D, 975508D]; National Science Council, Taiwan
   [NSC-98-2314-B075A-002-MY3]
FX This study was supported in part by grants from the Yen Tjing Ling
   Medical Foundation, Taiwan (CI-98-15), Taichung Veterans General
   Hospital, Taiwan (TCVGH-993102B, 983103B, 973102B, 973504D, 973111D,
   973002D, 975508D) and the National Science Council, Taiwan
   (NSC-98-2314-B075A-002-MY3). The authors would like to thank the
   Biostatistics Taskforce of Taichung Veterans General Hospital for
   statistical support.
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NR 41
TC 21
Z9 21
U1 0
U2 3
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0009-8981
EI 1873-3492
J9 CLIN CHIM ACTA
JI Clin. Chim. Acta
PD SEP 18
PY 2011
VL 412
IS 19-20
BP 1835
EP 1841
DI 10.1016/j.cca.2011.06.018
PG 7
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA 813UU
UT WOS:000294396500022
PM 21704607
DA 2025-06-11
ER

PT J
AU Kim, CK
   Kim, HJ
   Chung, HK
   Shin, D
AF Kim, Chul-Kyoo
   Kim, Hyun-jin
   Chung, Hae-Kyung
   Shin, Dayeon
TI Eating Alone is Differentially Associated with the Risk of Metabolic
   Syndrome in Korean Men and Women
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Article
DE eating alone; metabolic syndrome; obesity; Korea National Health and
   Nutrition Examination Survey (KNHANES)
ID NUTRITION EXAMINATION SURVEY; NATIONAL-HEALTH; MARITAL-STATUS; OXIDATIVE
   STRESS; ADULTS; MORTALITY; OBESITY
AB Few studies have examined overall patterns of eating alone in relation to the risk of metabolic syndrome (MetS) in Korean populations. The present study aimed to examine the relationship between patterns of eating alone and the risk of MetS in Korean adults. Data from the Korea National Health and Nutrition Examination Survey (KNHANES) for 2013-2015 were used, with 8988 Korean adult participants, including 3624 men and 5364 women, aged 18 to 64 years. Patterns of eating alone were categorized into eight groups based on the total frequency of eating alone on a daily basis in the past one year: (1) three times for breakfast, lunch, and dinner; (2) twice for breakfast and dinner; (3) twice for lunch and dinner; (4) twice for breakfast and lunch; (5) once for breakfast only; (6) once for lunch only; (7) once for dinner only; and (8) never eating alone. The presence of MetS has been defined by the National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) and International Diabetes Federation (IDF). Multivariable logistic regression analyses were performed to assess the association between patterns of eating alone versus the risk of MetS after controlling for age, income, occupation, number of family members, generation types, marital status, smoking status, and physical activity. The prevalence of MetS was the highest in men and women aged 40-64 who had breakfast, lunch, and dinner alone (50.1% and 36.8%, respectively). Men who had dinner alone or lunch and dinner alone compared with those who eat with others had a significantly higher risk of MetS, with adjusted odds ratios (AOR) of 1.51, and a 95% confidence interval (CI) of 1.06-2.16; and an AOR of 1.54, with a 95% CI of 1.05-2.25, respectively. Women who had breakfast alone compared with those who ate with others had a significantly lower risk of MetS (AOR 0.70, 95% CI 0.53-0.94). In conclusion, patterns of eating alone are differentially associated with the risk of MetS in a representative sample of Korean adults. Future studies are warranted to identify dietary patterns across the different eating alone patterns in relation to various health outcomes in Korean adult populations.
C1 [Kim, Chul-Kyoo; Kim, Hyun-jin] Korea Univ, Dept Sociol, Seoul 02841, South Korea.
   [Chung, Hae-Kyung] Hoseo Univ, Dept Food & Nutr, Asan 31499, South Korea.
   [Shin, Dayeon] Syracuse Univ, Dept Publ Hlth Food Studies & Nutr, Syracuse, NY 13244 USA.
C3 Korea University; Hoseo University; Syracuse University
RP Shin, D (corresponding author), Syracuse Univ, Dept Publ Hlth Food Studies & Nutr, Syracuse, NY 13244 USA.
EM ckkim@korea.ac.kr; combabe@naver.com; hkchung@hoseo.edu; dshin03@syr.edu
RI Shin, Dayeon/GMX-2004-2022
OI Shin, Dayeon/0000-0003-0828-184X
FU Ministry of Education of the Republic of Korea; National Research
   Foundation of Korea [NRF-2016S1A3A2924243]
FX This work was supported by the Ministry of Education of the Republic of
   Korea and the National Research Foundation of Korea
   (NRF-2016S1A3A2924243).
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NR 36
TC 9
Z9 10
U1 0
U2 3
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD MAY
PY 2018
VL 15
IS 5
AR 1020
DI 10.3390/ijerph15051020
PG 14
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA GJ3LS
UT WOS:000435197300188
PM 29783657
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Villalpando, S
   Carrión, C
   Barquera, S
   Olaiz-Fernández, G
   Robledo, R
AF Villalpando, Salvador
   Carrion, Citlalli
   Barquera, Simon
   Olaiz-Fernandez, Gustavo
   Robledo, Ricardo
TI Body mass index associated with hyperglycemia and alterations of
   components of metabolic syndrome in Mexican adolescents
SO SALUD PUBLICA DE MEXICO
LA English
DT Article
DE obesity; adolescents; hyperglycemia; insulin; cholesterol;
   HDL-cholesterol
ID DEPENDENT DIABETES-MELLITUS; RISK-FACTORS; CARDIOVASCULAR-DISEASE;
   AMERICAN CHILDREN; OBESITY; OVERWEIGHT; DEFINITION; PREVENTION;
   PREVALENCE
AB Objective. This research aims to describe the epidemiology of obesity and its association with alterations in some components of metabolic syndrome, such as serum concentrations of glucose, insulin, and some lipids in a sub-sample of the Mexican Health Survey (MHS) of youth ages 10 to 19 years. Material and Methods. This analysis is based on a randomly selected sub-sample of the MHS of 20% of the youth ages 10 to 19 years (n = 1977), carried-out in Mexico in the year 2000 and distinguishes differences between national, rural and urban areas as well as four geographical country regions. Serum concentrations of glucose, insulin, triglycerides (TG), total cholesterol (TC) and HDL-cholesterol (HDLc) were measured. The protocol was approved by the Ethics Committee of the Mexican National Institute of Public Health. Results. Overall, 14.8% of the individuals were overweight, 6.7% were obese and 37.5% had a family history of type 2 diabetes mellitus (DM2). The overall mean concentrations of glucose, insulin, total cholesterol, and triglycerides were significantly higher and those of HDLc were significantly lower in obese subjects than in individuals with normal Body Mass Index (BMI) (p < 0.05-0.001). The probability ratio (PR) of being in quintile 5 for glucose distribution was significantly higher for obese males and females (RP = 2.1, p < 0.001) than for their non-obese counterparts. It was also higher for females with a history of DM2 (RP = 1.12, p < 0.02), but not for males. The PR of being in quintile 5 for insulin distribution was significantly higher for obese males (RP = 3.51, p < 0.001) and females (RP = 3.3, p < 0.001) than for non-obese counterparts. It was also higher for male (RP = 1.28, p < 0.02) and female (RP = 1.27, p < 0.02) subjects with a history of DM2. Finally, the PR for being in quintile 5 for TG distribution was significantly higher for obese males (RP = 4.71, p < 0.001) and females (RP = 1.75, p < 0.001) than for their non-obese counterparts. Discussion. A strong association between obesity and the risk of higher concentrations of glucose, insulin, TG, and TC and a lower concentration of HDLc in youth has been demonstrated. These findings stress the risk of obesity at these early ages, with alterations in some of the components of metabolic syndrome.
C1 Inst Nacl Salud Publ, Mexico City, DF, Mexico.
   Secretaria Salud Mexico, Mexico City, DF, Mexico.
C3 Instituto Nacional de Salud Publica
RP Villalpando, S (corresponding author), Av Univ 655,Col Santa Maria Ahuacatitlan, Cuernavaca 62508, Morelos, Mexico.
EM svillalp@insp.mx
RI Villalpando, Salvador/AAS-3874-2021
OI Villalpando, Salvador/0000-0001-6429-3816
CR [Anonymous], ENCUESTA NACL NUTR 1
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NR 37
TC 12
Z9 17
U1 0
U2 5
PU INST NACIONAL SALUD PUBLICA
PI CUERNAVACA
PA AV UNIVERSIDAD 655, COL SANTA MARIA AHUACATITLAN, CUERNAVACA 62508,
   MORELOS, MEXICO
SN 0036-3634
EI 1606-7916
J9 SALUD PUBLICA MEXICO
JI Salud Publica Mexico
PY 2007
VL 49
SU 3
BP S324
EP S330
DI 10.1590/S0036-36342007000900003
PG 7
WC Public, Environmental & Occupational Health
WE Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA 196MV
UT WOS:000248487600003
OA gold
DA 2025-06-11
ER

PT J
AU Vancamp, P
   Frapin, M
   Parnet, P
   Amarger, V
AF Vancamp, Pieter
   Frapin, Morgane
   Parnet, Patricia
   Amarger, Valerie
TI Unraveling the Molecular Mechanisms of the Neurodevelopmental
   Consequences of Fetal Protein De fi ciency: Insights From Rodent Models
   and Public Health Implications
SO BIOLOGICAL PSYCHIATRY: GLOBAL OPEN SCIENCE
LA English
DT Review
ID INTRAUTERINE GROWTH RESTRICTION; PRENATAL FAMINE EXPOSURE;
   AMINO-ACID-TRANSPORT; DUTCH-HUNGER-WINTER; DEVELOPMENTAL ORIGINS;
   PLACENTAL TRANSPORT; POSTNATAL-GROWTH; RAT MODEL; METABOLIC SYNDROME;
   BRAIN-DEVELOPMENT
AB Fetal brain development requires increased maternal protein intake to ensure that offspring reach their optimal cognitive potential in infancy and adulthood. While protein deficiency remains a prevalent issue in developing countries, it is also reemerging in Western societies due to the growing adoption of plant-based diets, some of which are monotonous and may fail to provide sufficient amino acids crucial for the brain's critical developmental phase. Confounding variables in human nutritional research have impeded our understanding of the precise impact of protein deficiency on fetal neurodevelopment, as well as its implications for childhood neurocognitive performance. Moreover, it remains unclear whether such deficiency could predispose to mental health problems in adulthood, mirroring observations in individuals exposed to prenatal famine. In this review, we sought to evaluate mechanistic data derived from rodent models, placing special emphasis on the involvement of neuroendocrine axes, the influence of sex and timing, epigenetic modifications, and cellular metabolism. Despite notable progress, critical knowledge gaps remain, including understanding the long-term reversibility of effects due to fetal protein restriction and the interplay between genetic predisposition and environmental factors. Enhancing our understanding of the precise mechanisms that connect prenatal nutrition to brain development in future research endeavors can be significantly advanced by integrating multiomics approaches and utilizing additional alternative models such as nonhuman primates. Furthermore, it is crucial to investigate potential interventions aimed at alleviating adverse outcomes. Ultimately, this research has profound implications for guiding public health strategies aimed at raising awareness about the crucial role of optimal maternal nutrition in supporting fetal neurodevelopment.
C1 [Vancamp, Pieter; Parnet, Patricia; Amarger, Valerie] Nantes Univ, Inst Natl Rech Agr Alimentat & Environm INRAE, Inst Malad Appareil Digest IMAD, Physiopathol Adaptat Nutr PhAN,UMR1280, Nantes, France.
   [Frapin, Morgane] Univ Helsinki, Fac Biol & Environm Sci, Organismal & Evolutionary Biol Res Programme, Helsinki, Finland.
C3 INRAE; Nantes Universite; University of Helsinki
RP Vancamp, P (corresponding author), Nantes Univ, Inst Natl Rech Agr Alimentat & Environm INRAE, Inst Malad Appareil Digest IMAD, Physiopathol Adaptat Nutr PhAN,UMR1280, Nantes, France.
EM Pieter.vancamp@univ-nantes.fr
RI Vancamp, Pieter/AAB-2963-2020; Frapin, Morgane/KLD-0185-2024
OI Frapin, Morgane/0000-0002-9540-6518; Vancamp, Pieter/0000-0002-0230-2833
FU Departement Alimentation Humaine (ALIMH); Institut National de Recherche
   pour l'Agriculture, l'Alimentation et l'Environnement (INRAE)
FX This work was supported by the Departement Alimentation Humaine (ALIMH)
   , Institut National de Recherche pour l'Agriculture, l'Alimentation et
   l'Environnement (INRAE) (to PV) .
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NR 143
TC 0
Z9 0
U1 0
U2 3
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2667-1743
J9 BIOL PSYCHIAT-GLOB O
JI Biol. Psychiatr.-Glob. Open Sci.
PD SEP
PY 2024
VL 4
IS 5
AR 100339
DI 10.1016/j.bpsgos.2024.100339
EA JUN 2024
PG 13
WC Neurosciences; Psychiatry
WE Emerging Sources Citation Index (ESCI)
SC Neurosciences & Neurology; Psychiatry
GA XO0F1
UT WOS:001262500700001
PM 39040432
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Olszanecka-Glinianowicz, M
   Zygmuntowicz, M
   Owczarek, A
   Elibol, A
   Chudek, J
AF Olszanecka-Glinianowicz, Magdalena
   Zygmuntowicz, Monika
   Owczarek, Aleksander
   Elibol, Adam
   Chudek, Jerzy
TI The impact of overweight and obesity on health-related quality of life
   and blood pressure control in hypertensive patients
SO JOURNAL OF HYPERTENSION
LA English
DT Article
DE hypertension; obesity; overweight; quality of life; SF-12
ID BODY-MASS INDEX; CARDIOVASCULAR RISK; METABOLIC SYNDROME; UNITED-STATES;
   US ADULTS; PREVALENCE; TRENDS; MEN; INTERVENTIONS; ASSOCIATION
AB Objective:Hypertension and obesity deteriorate patient health-related quality-of-life (HRQoL). This study assessed the impact of overweight and obesity on HRQoL and blood pressure (BP) control in hypertensive participants, according to sex.Methods:HRQoL was assessed using the 12-item Short Form Health Survey in 11498 white patients treated for hypertension for at least 12 months. Nutritional status was diagnosed according to WHO criteria.Results:Overweight and obesity were associated with worse BP control, regardless of sex. In women, overweight and especially obesity were inversely associated with all analyzed HRQoL dimensions. Among men, obesity decreased all HRQoL dimensions, and overweight influenced only physical functioning, role physical, bodily pain, vitality, general health, and Physical Component Score (PCS) but not Mental Component Score (MCS). Overweight in men did not influence social functioning, or emotional and mental health. The BMI values associated with optimal PCS and MCS scores were higher for men than for women. Age-adjusted multivariate regression analysis revealed that PCS score was associated with obesity, higher education level, comorbidities, and antihypertensive therapy duration, whereas MCS score was associated with female sex. Polydrug BP control diminished PCS and MCS.Conclusion:Overweight and obesity deteriorate BP control, regardless of age and polytherapy. BMI values associated with optimal HRQoL are higher for men than women treated for hypertension. Obesity more strongly diminishes the physical versus mental HRQoL component, regardless of sex. Overweight worsens HRQoL physical components in both sexes and mental component-only in women.
C1 [Olszanecka-Glinianowicz, Magdalena] Med Univ Silesia, Dept Pathophysiol, Hlth Promot & Obes Management Unit, PL-40752 Katowice, Poland.
   [Zygmuntowicz, Monika; Elibol, Adam; Chudek, Jerzy] Dept Pathophysiol, Pathophysiol Unit, Katowice, Poland.
   [Owczarek, Aleksander] Dept Instrumental Anal, Div Stat, Sosnowiec, Poland.
C3 Medical University of Silesia
RP Chudek, J (corresponding author), Med Univ Silesia, Dept Pathophysiol, St Medykow 18, PL-40752 Katowice, Poland.
EM chj@poczta.fm
RI Chudek, Jerzy/I-2826-2019
OI Chudek, Jerzy/0000-0002-6367-7794; Owczarek, Aleksander
   Jerzy/0000-0003-1179-6932; Olszanecka-Glinianowicz,
   Magdalena/0000-0001-5632-5590
FU pharmaceutical company EGIS Polska Sp. z o.o.
FX This study was funded by the pharmaceutical company EGIS Polska Sp. z
   o.o., and was organized by Europharma M. Rachtan Sp. z o.o., which
   provided assistance in the field of medical services
   (http://www.europharma.edu.pl/eng/). J.C. designed the study and is the
   copyright holder.
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NR 52
TC 21
Z9 22
U1 0
U2 11
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0263-6352
EI 1473-5598
J9 J HYPERTENS
JI J. Hypertens.
PD FEB
PY 2014
VL 32
IS 2
BP 397
EP 407
DI 10.1097/HJH.0000000000000046
PG 11
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Cardiovascular System & Cardiology
GA AA1SM
UT WOS:000330876000025
PM 24366035
DA 2025-06-11
ER

PT J
AU Kim, M
   Yang, SJ
   Kim, HH
   Jo, A
   Jhon, M
   Lee, JY
   Ryu, SH
   Kim, JM
   Kweon, YR
   Kim, SW
AF Kim, Mina
   Yang, Soo Jin
   Kim, Hyang Hee
   Jo, Anna
   Jhon, Min
   Lee, Ju-Yeon
   Ryu, Seung-Hyung
   Kim, Jae -Min
   Kweon, Young -Ran
   Kim, Sung -Wan
TI Effects of Dietary Habits on General and Abdominal Obesity in
   Community-dwelling Patients with Schizophrenia
SO CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE
LA English
DT Article
DE Abdominal obesity; Dietary habits; Eating; Metabolic syndrome; Obesity;
   Schizophrenia
ID BODY-MASS INDEX; NAIVE SCHIZOPHRENIA; RISK-FACTOR; WEIGHT; FOOD;
   BEHAVIORS; SYMPTOMS; PATTERNS; DISEASE
AB Objective: To investigate the effects of dietary habits on general and abdominal obesity in community-dwelling patients with schizophrenia spectrum disorder according to sex. Methods: A total of 270 patients with schizophrenia spectrum disorder registered at mental health welfare centers and rehabilitation facilities were recruited. General obesity was defined as a body mass index >= 30 kg/m(2), and abdominal obesity was defined as a waist circumstance >= 90 cm in men and >= 85 cm in women. Dietary habits were evaluated using dietary guidelines published by the Korean Ministry of Health and Welfare. Demographic and clinical characteristics along with dietary habits and information related to obesity were collected. Factors related to obesity were evaluated separately by sex.Results: Dietary habits differed according to sex, in that scores for healthy eating habits were lower in men than in women. In men, the prevalences of general and abdominal obesity were 17.0% and 37.3%, respectively. In women, the prevalences of general and abdominal obesity were 23.1% and 38.5%, respectively. Regression analysis showed that the scores of regular eating habits were negatively associated with general and abdominal obesity in men, and the scores of healthy eating habits were negatively associated with general and abdominal obesity in women.Conclusion: Among patients with schizophrenia, regular eating habits might reduce the risk of obesity in men, and healthy eating habits might reduce the risk of obesity in women. Nutrition education should be provided to community-dwelling patients with schizophrenia to prevent obesity in this population.
C1 [Yang, Soo Jin] Chonnam Natl Univ, Dept Nursing, Gwangju, South Korea.
   [Yang, Soo Jin; Kim, Sung -Wan] Seoul Womens Univ, Dept Food & Nutr, Seoul, South Korea.
   [Kim, Hyang Hee; Kim, Sung -Wan] Gwangju Bukgu Community Mental Hlth Ctr, Gwangju, South Korea.
   [Jo, Anna; Jhon, Min; Lee, Ju-Yeon; Ryu, Seung-Hyung; Kim, Jae -Min; Kim, Sung -Wan] Chonnam Natl Univ Med Sch, Dept Psychiat, Gwangju, South Korea.
   [Yang, Soo Jin] Seoul Womens Univ, Dept Food & Nutr, 621 Hwarang ro, Seoul, South Korea.
   [Kim, Sung -Wan] Chonnam Natl Univ Med Sch, 160 Baekseo ro, Gwangju, South Korea.
C3 Chonnam National University; Seoul Women's University; Chonnam National
   University; Seoul Women's University; Chonnam National University
RP Yang, SJ (corresponding author), Seoul Womens Univ, Dept Food & Nutr, 621 Hwarang ro, Seoul, South Korea.; Kim, SW (corresponding author), Chonnam Natl Univ Med Sch, 160 Baekseo ro, Gwangju, South Korea.
EM sjyang89@swu.ac.kr; swkim@chonnam.ac.kr
RI Lee, Jung-Seok/L-6826-2019; Kweon, Young Ran/IWU-7667-2023; KIM,
   Jae-Min/S-7637-2019; Kweon, Young-Ran/HHM-7426-2022; Kim,
   Mina/JMP-2847-2023
OI Kim, Sung-Wan/0000-0002-6739-2163; KIM, JAE-MIN/0000-0001-7409-6306;
   Kweon, Young-Ran/0000-0002-4885-4238; Kim, Mina/0000-0003-2295-6786;
   Jhon, Min/0000-0002-0408-768X; Ryu, Seunghyong/0000-0001-6127-760X;
   Yang, Soo Jin/0000-0001-7892-7648; Jo, Anna/0000-0002-9820-5826
FU Basic Science Research Program through the National Research Foundation
   of Korea [NRF-2017R1A2B4010830]
FX ? Funding This study was supported by a grant from the Basic Science
   Research Program through the National Research Foundation of Korea
   (NRF-2017R1A2B4010830) .
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   WHO, 2014, GLOBAL STATUS REPORT ON VIOLENCE PREVENTION 2014, P1
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NR 44
TC 4
Z9 4
U1 0
U2 2
PU KOREAN COLL NEUROPSYCHOPHARMACOLOGY
PI SEOUL
PA RN 1003 OFFICETEL 40, 63-RO YEONGDEUNGPO-GU, SEOUL, 150-731, SOUTH KOREA
SN 1738-1088
EI 2093-4327
J9 CLIN PSYCHOPHARM NEU
JI Clin. Psychopharmacol. Neurosci.
PD FEB
PY 2023
VL 21
IS 1
BP 68
EP 76
DI 10.9758/cpn.2023.21.1.68
PG 9
WC Neurosciences; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pharmacology & Pharmacy
GA 8S2EE
UT WOS:000928396500006
PM 36700313
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Patel, D
   Msosa, YJ
   Wang, T
   Mustafa, OG
   Gee, S
   Williams, J
   Roberts, A
   Dobson, RJB
   Gaughran, F
AF Patel, Dipen
   Msosa, Yamiko J.
   Wang, Tao
   Mustafa, Omar G.
   Gee, Siobhan
   Williams, Julie
   Roberts, Angus
   Dobson, Richard J. B.
   Gaughran, Fiona
TI An implementation framework and a feasibility evaluation of a clinical
   decision support system for diabetes management in secondary mental
   healthcare using CogStack
SO BMC MEDICAL INFORMATICS AND DECISION MAKING
LA English
DT Article
DE Alerting; Clinical decision support; CogStack; Diabetes; EHealth;
   Pre-diabetes; Monitoring
ID METABOLIC SYNDROME; BIPOLAR DISORDER; SCHIZOPHRENIA; PEOPLE; GUIDELINES;
   RISK; COMPLICATIONS; MORTALITY; MELLITUS; ADULTS
AB Background Improvements to the primary prevention of physical health illnesses like diabetes in the general population have not been mirrored to the same extent in people with serious mental illness (SMI). This work evaluates the technical feasibility of implementing an electronic clinical decision support system (eCDSS) for supporting the management of dysglycaemia and diabetes in patients with serious mental illness in a secondary mental healthcare setting. Methods A stepwise approach was taken as an overarching and guiding framework for this work. Participatory methods were employed to design and deploy a monitoring and alerting eCDSS. The eCDSS was evaluated for its technical feasibility. The initial part of the feasibility evaluation was conducted in an outpatient community mental health team. Thereafter, the evaluation of the eCDSS progressed to a more in-depth in silico validation. Results A digital health intervention that enables monitoring and alerting of at-risk patients based on an approved diabetes management guideline was developed. The eCDSS generated alerts according to expected standards and in line with clinical guideline recommendations. Conclusions It is feasible to design and deploy a functional monitoring and alerting eCDSS in secondary mental healthcare. Further work is required in order to fully evaluate the integration of the eCDSS into routine clinical workflows. By describing and sharing the steps that were and will be taken from concept to clinical testing, useful insights could be provided to teams that are interested in building similar digital health interventions.
C1 [Msosa, Yamiko J.; Wang, Tao; Roberts, Angus; Dobson, Richard J. B.] Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Biostat & Hlth Informat, De Crespigny Pk, London SE5 8AB, England.
   [Patel, Dipen; Msosa, Yamiko J.; Wang, Tao; Roberts, Angus; Dobson, Richard J. B.; Gaughran, Fiona] South London & Maudsley Natl Hlth Serv Fdn Trust, Natl Inst Hlth Res, Maudsley Biomed Res Ctr, De Crespigny Pk, London SE5 8AB, England.
   [Patel, Dipen; Gaughran, Fiona] Kings Coll London, Dept Psychosis Studies, Inst Psychiat Psychol & Neurosci, De Crespigny Pk, London SE5 8AB, England.
   [Patel, Dipen; Gee, Siobhan; Gaughran, Fiona] South London & Maudsley NHS Fdn Trust, London, England.
   [Mustafa, Omar G.] Kings Coll Hosp NHS Fdn Trust, Dept Diabet, Denmark Hill, London SE5 9RS, England.
   [Mustafa, Omar G.] Kings Coll London, Fac Life Sci & Med, Ctr Educ, London, England.
   [Williams, Julie] Kings Coll London, Ctr Implementat Sci, Hlth Serv & Populat Res Dept, London, England.
   [Dobson, Richard J. B.] UCL, Inst Hlth Informat, London, England.
   [Dobson, Richard J. B.] UCL, Hlth Data Res UK London, London, England.
C3 University of London; King's College London; University of London;
   King's College London; South London & Maudsley NHS Trust; University of
   London; King's College London; South London & Maudsley NHS Trust; King's
   College Hospital NHS Foundation Trust; University of London; King's
   College London; University of London; King's College London; University
   of London; University College London; University of London; University
   College London
RP Msosa, YJ (corresponding author), Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Biostat & Hlth Informat, De Crespigny Pk, London SE5 8AB, England.; Msosa, YJ (corresponding author), South London & Maudsley Natl Hlth Serv Fdn Trust, Natl Inst Hlth Res, Maudsley Biomed Res Ctr, De Crespigny Pk, London SE5 8AB, England.
EM yamiko.msosa@kcl.ac.uk
RI Williams, Julie/JYQ-5874-2024; Gaughran, Fiona/AAC-7160-2019; Wang,
   Tao/IZQ-3814-2023; Mustafa, Omar/ABI-1655-2020; dobson,
   richard/C-9269-2011; Gaughran, Fiona/H-5495-2011
OI Wang, Tao/0000-0002-0437-0557; dobson, richard/0000-0003-4224-9245;
   Roberts, Angus/0000-0002-4570-9801; Patel, Dipen/0000-0003-2341-7901;
   Mustafa, Omar G./0000-0003-3123-809X; Gaughran,
   Fiona/0000-0001-7414-5569; Williams, Julie/0000-0002-8861-0596
FU Maudsley Charity; National Institute for Health Research's (NIHR)
   Biomedical Research Centre at South London and Maudsley NHS Foundation
   Trust and King's College London; National Institute for Health Research
   (NIHR) Applied Research Collaboration South London (NIHR ARC South
   London) at King's College Hospital NHS Foundation Trust
FX This work was supported by: (a) the Maudsley Charity; (b) the National
   Institute for Health Research's (NIHR) Biomedical Research Centre at
   South London and Maudsley NHS Foundation Trust and King's College
   London, the Maudsley Charity and the National Institute for Health
   Research (NIHR) Applied Research Collaboration South London (NIHR ARC
   South London) at King's College Hospital NHS Foundation Trust. The views
   expressed are those of the authors and not necessarily those of the NIHR
   or the Department of Health and Social Care. The authors would like to
   thank Dr Tom Werner (consultant psychiatrist at SLaM) for facilitating
   initial testing of the eCDSS in the CMHT setting and Dr Matt Butler
   (Core Trainee in psychiatry at SLaM) for his contribution to the
   in-silico validation.
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NR 48
TC 3
Z9 3
U1 0
U2 4
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1472-6947
J9 BMC MED INFORM DECIS
JI BMC Med. Inform. Decis. Mak.
PD APR 14
PY 2022
VL 22
IS 1
AR 100
DI 10.1186/s12911-022-01842-5
PG 11
WC Medical Informatics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Medical Informatics
GA 0N1JD
UT WOS:000782601800001
PM 35421974
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Kasai, Y
   Suzuki, E
   Iwase, T
   Doi, H
   Takao, S
AF Kasai, Yosuke
   Suzuki, Etsuji
   Iwase, Toshihide
   Doi, Hiroyuki
   Takao, Soshi
TI Type D Personality Is Associated with Psychological Distress and Poor
   Self-Rated Health among the Elderly: A Population-Based Study in Japan
SO PLOS ONE
LA English
DT Article
ID CORONARY-HEART-DISEASE; GENERAL-POPULATION; 5-FACTOR MODEL; NEGATIVE
   AFFECTIVITY; DEPRESSIVE SYMPTOMS; METABOLIC SYNDROME; SOCIAL INHIBITION;
   SCREENING SCALES; MENTAL-HEALTH; A-BEHAVIOR
AB We investigated the association between Type D personality, psychological distress, and self-ratings of poor health in elderly Japanese people. In August 2010, questionnaires were sent to all residents aged >= 65 in three municipalities (n = 21232) in Okayama Prefecture, Japan, and. 13929 questionnaires were returned (response rate: 65.6%). To assess mental and physical health outcomes, we used the Kessler Psychological Distress Scale and a single item question regarding perceived general health. We analyzed 9759 questionnaires to determine odds ratios (ORs) and 95% confidence intervals (CIs) for several health outcomes, adjusting for sex, age, smoking status, frequency of alcohol consumption, overweight status, educational attainment, socioeconomic status, and number of cohabiters. The multiple imputation method was employed for missing data regarding Type D personality. The prevalence of Type D personality in our sample was 46.2%. After adjusting for covariates, we found that participants with Type D personality were at 4-5 times the risk of psychological distress, and twice the risk of poor self-rated health. This association was stronger in participants aged 65-74 years (psychological distress; OR: 5.80, 95% CI: 4.96-6.78, poor self-rated health; OR: 2.84, 95% CI: 2.38-3.38) than in those aged over 75 years (psychological distress; OR: 4.54, 95% CI: 3.96-5.19, poor self-rated health; OR: 2.05, 95% CI: 1.79-2.34). Type D personality is associated with adverse health status among Japanese elderly people in terms of mental and physical risk; therefore, further research into the implications of this personality type is warranted.
C1 [Kasai, Yosuke; Suzuki, Etsuji; Doi, Hiroyuki; Takao, Soshi] Okayama Univ, Dept Epidemiol, Grad Sch Med Dent & Pharmaceut Sci, Okayama 7008530, Japan.
   [Iwase, Toshihide] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Support Ctr Med Cooperat Human Resource Placement, Okayama 7008530, Japan.
C3 Okayama University; Okayama University
RP Kasai, Y (corresponding author), Okayama Univ, Dept Epidemiol, Grad Sch Med Dent & Pharmaceut Sci, Okayama 7008530, Japan.
EM yosuke.kasai@gmail.com
RI Suzuki, Etsuji/B-2342-2011
FU Fund for Urgent Improvement of Local Suicide Prevention Measures from
   the Cabinet Office; Ministry of Health, Labor and Welfare of the
   Japanese Government
FX This study was supported in part by a grant from the Fund for Urgent
   Improvement of Local Suicide Prevention Measures from the Cabinet Office
   and the Ministry of Health, Labor and Welfare of the Japanese
   Government. Neither this entity nor the institution to which both
   authors are affiliated has any financial interest in or financial
   conflict with the subject matter of this manuscript. The funders had no
   role in study design, data collection and analysis, decision to publish,
   or preparation of the manuscript.
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NR 47
TC 15
Z9 15
U1 0
U2 19
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD OCT 17
PY 2013
VL 8
IS 10
AR e77918
DI 10.1371/journal.pone.0077918
PG 7
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Science & Technology - Other Topics
GA 239KL
UT WOS:000326022200087
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Sun, SY
   He, DJ
   Luo, C
   Lin, XH
   Wu, JH
   Yin, XY
   Jia, CF
   Pan, QQ
   Dong, XH
   Zheng, FP
   Li, H
   Zhou, JQ
AF Sun, Shuiya
   He, Dongjuan
   Luo, Cheng
   Lin, Xihua
   Wu, Jiahua
   Yin, Xueyao
   Jia, Chengfang
   Pan, Qianqian
   Dong, Xuehong
   Zheng, Fenping
   Li, Hong
   Zhou, Jiaqiang
TI Metabolic Syndrome and Its Components Are Associated With Altered Amino
   Acid Profile in Chinese Han Population
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Article
DE amino acid; metabolic syndrome; component; biomarkers; amino acid
   profile
ID BETA-CELL FUNCTION; INSULIN-RESISTANCE; BRANCHED-CHAIN;
   CARDIOVASCULAR-DISEASE; OXIDATIVE STRESS; POTENTIAL ROLE; TAURINE;
   SERUM; OBESE; RISK
AB ObjectiveRecent studies have found that the levels of plasma amino acids, such as branched-chain amino acids and aromatic amino acids, were associated with visceral obesity, insulin resistance, future development of diabetes and cardiovascular diseases. However, few studies have involved a Chinese Han population. This study aimed to examine the association between amino acid profile and metabolic syndrome (MetS) and its components in the Chinese Han population. MethodsThis is a cross-sectional study, which enrolled a cohort of 473 participants from a community. We employed the isotope internal standard method to determine the plasma concentrations of 28 amino acids using high-performance liquid chromatography-tandem mass spectrometry (LC/MS). Participants were divided into MetS (n = 72) and non-MetS groups (n = 401) to analyze the association between amino acids and MetS and its components. ResultsThe prevalence of MetS was 15.2% according to the criteria. Plasma concentrations of isoleucine (Ile), leucine (Leu), valine (Val), tyrosine (Tyr), tryptophan (Trp), phenylalanine (Phe), glutamic acid (Glu), aspartic acid (Asp), alanine (Ala), histidine (His), methionine (Met), asparagine (Asn), and proline (Pro) were significantly higher in the MetS group than those in the non-MetS group (P < 0.05), but taurine (Tau) was significantly lower (P < 0.05). When MetS components were increased, the concentrations of these 13 amino acids significantly increased (P < 0.05), but Tau concentration was significantly decreased (P < 0.05). We extracted the amino acid profile by principal component analysis (PCA), PC1 and PC2, which extracted from the 14 amino acids, were significantly associated with MetS (odds ratio, 95% confidence interval: 1.723, 1.325-2.085 and 1.325, 1.043-1.684, respectively). A total of 260 non-MetS participants were followed up effectively, and 42 participants developed new-onset MetS within 5 years. We found that the amino acid profile of PC1 was linked to the occurrence of future MetS. Decreased Tau was correlated with the future development of MetS. ConclusionParticipants with MetS exhibit an abnormal amino acid profile, and its components gradually increase when these amino acids are altered. Amino acid PCA profile can be employed for assessing and monitoring MetS risk. Finally, decreased Tau may be linked to the future development of MetS.
C1 [Sun, Shuiya; He, Dongjuan; Luo, Cheng; Lin, Xihua; Wu, Jiahua; Yin, Xueyao; Jia, Chengfang; Pan, Qianqian; Dong, Xuehong; Zheng, Fenping; Li, Hong; Zhou, Jiaqiang] Zhejiang Univ, Sir Run Run Shaw Hosp, Dept Endocrinol, Sch Med, Hangzhou, Peoples R China.
   [He, Dongjuan; Luo, Cheng] Peoples Hosp Quzhou, Dept Endocrinol, Quzhou, Peoples R China.
C3 Zhejiang University
RP Li, H; Zhou, JQ (corresponding author), Zhejiang Univ, Sir Run Run Shaw Hosp, Dept Endocrinol, Sch Med, Hangzhou, Peoples R China.
EM srrshnfm@zju.edu.cn; zjq8866@zju.edu.cn
RI Lin, Xihua/HGB-1950-2022
FU Program for Zhejiang Leading Team of Science and Technology Innovation
   [2012R10050-03]
FX Funding This work was supported by the Program for Zhejiang Leading Team
   of Science and Technology Innovation (2012R10050-03).
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NR 45
TC 21
Z9 21
U1 1
U2 13
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD JAN 4
PY 2022
VL 12
AR 795044
DI 10.3389/fendo.2021.795044
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA YR5VE
UT WOS:000750062000001
PM 35058883
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Chen, JH
   Chen, WL
   Shiu, CS
AF Chen, Jen-Hao
   Chen, Wei-Lin
   Shiu, Cheng-Shi
TI A scoping review of determinants of indigenous health and health
   disparities in Taiwan: present evidence and paradigms
SO JOURNAL OF POPULATION RESEARCH
LA English
DT Review
DE East Asia; Health disparities; Indigenous wellbeing; Minority health;
   Social determinants of health
ID RISK-FACTORS; ABORIGINAL TAIWANESE; ERECTILE DYSFUNCTION;
   ETHNIC-DIFFERENCES; METABOLIC SYNDROME; DIABETES-MELLITUS;
   BLOOD-PRESSURE; HAN CHINESE; ALCOHOL-USE; PREVALENCE
AB The literature on indigenous health and health disparities primarily focuses on Western countries such as Australia, Canada, New Zealand, and the United States. Nonetheless, an emerging but dispersed corpus of research exists on the determinants of health and health disparities among indigenous populations in Taiwan, a developed nation with sizable indigenous communities. Despite these developments, an understanding of current scholarship on the determinants of indigenous health and health disparities remains lacking. To bridge this gap, we systematically searched PubMed/Medline, Web of Science databases, and the Airiti Library, the most comprehensive Chinese database in Taiwan. By December 31, 2022, we identified 54 relevant studies, including 48 peer-reviewed articles in English and 6 in Chinese. These studies reveal significant disparities in mortality rates and the burden of infectious and chronic diseases between indigenous and non-indigenous populations. Factors contributing to the comparatively poorer health of indigenous communities include genetic predispositions, sociodemographic marginalization, and lifestyle choices. The studies employ diverse methodologies, ranging from small convenience samples to nationally representative data. Our analysis identified four paradigms (biomedical, epidemiological, anthropological, and historical/critical), with most focusing on biomedical and epidemiological perspectives. This review also underscores the scarcity of social-behavioral health research dedicated to indigenous health in Taiwan, highlighting the need for future studies to develop robust conceptual models, collect longitudinal data, and focus more on mental health and psychological well-being. These efforts are crucial for gaining a clearer understanding of indigenous health complexities in Taiwan and informing effective policies.
C1 [Chen, Jen-Hao] Natl Chengchi Univ, Dept Psychol, Sect 64 2,Zhinan Rd, Taipei City 11605, Taiwan.
   [Chen, Jen-Hao] Natl Chengchi Univ, Dept Psychol, Zhinan Rd,Sect 64 2, Taipei 11605, Taiwan.
   [Chen, Wei-Lin] Natl Sun Yat Sen Univ, Ctr Teacher Educ, Kaohsiung, Taiwan.
   [Shiu, Cheng-Shi] Natl Taiwan Univ, Dept Social Work, Taipei City, Taiwan.
C3 National Chengchi University; National Chengchi University; National Sun
   Yat Sen University; National Taiwan University
RP Chen, JH (corresponding author), Natl Chengchi Univ, Dept Psychol, Sect 64 2,Zhinan Rd, Taipei City 11605, Taiwan.; Chen, JH (corresponding author), Natl Chengchi Univ, Dept Psychol, Zhinan Rd,Sect 64 2, Taipei 11605, Taiwan.
EM jenhao@nccu.edu.tw
RI Chen, Weilin/AAB-7953-2022
FU National Science Council
FX No Statement Available
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NR 73
TC 1
Z9 1
U1 1
U2 2
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1443-2447
EI 1835-9469
J9 J POPUL RES
JI J. Popul. Res.
PD JUN
PY 2024
VL 41
IS 2
AR 10
DI 10.1007/s12546-024-09332-3
PG 24
WC Demography
WE Emerging Sources Citation Index (ESCI)
SC Demography
GA OK4M6
UT WOS:001207151500001
DA 2025-06-11
ER

PT J
AU Prasad, M
   Goswami, S
   Chinnaswamy, G
   Banavali, SD
   Kurkure, PA
AF Prasad, Maya
   Goswami, Savita
   Chinnaswamy, Girish
   Banavali, Shripad D.
   Kurkure, Purna A.
TI Long-Term Outcomes in Survivors of Childhood Cancer: A 30-Year
   Experience From India
SO JCO GLOBAL ONCOLOGY
LA English
DT Article
ID NEUROCOGNITIVE OUTCOMES; ADULT SURVIVORS; FOLLOW-UP; RETINOBLASTOMA;
   CHILDREN; RISK; CARE
AB PURPOSE Despite an increasing number of survivors of childhood cancer (CCS) in low- and middle-income countries, survivorship care is in its nascent stages. We describe the spectrum of late effects seen, challenges faced, and lessons learnt over three decades of a late effects program in India.
   METHODS We describe the demographics and profile of late effects of all CCS survivors enrolled in our After Completion of Treatment Clinic from February 5, 1991 (inception) to February 4, 2021. We analyzed the trends by the decade of diagnosis.
   RESULTS There were 3,067 CCS survivors, the median age was 18 years (range, 3-57 years), and the median follow-up was 11 years (range, 2-46 years). Two thirds (62.4%) had either no or mild late effects, 480 (15.6%), 497 (16.2%), and 162 (5.3%) had grades 2, 3, and 4 late effects, with 67 deaths reported. Notable late effects were chronic viral hepatitis (7.8%), thyroid dysfunction (7.5%), other endocrine issues (13.6%), psychosocial issues (57%), neurocognitive impairment (4.1%), and metabolic syndrome (4%). The cumulative incidence and severity of late effects showed a consistent decline by the decade of diagnosis. Twenty-two percent of survivors are lost to follow-up.
   CONCLUSION Survivors of childhood cancer treated on contemporary treatment protocols have a significantly lower side-effect profile. Attrition to long-term follow-up and psychosocial issues are significant concerns. Understanding the unique spectrum of late effects and establishing a holistic support system go a long way in ensuring the long-term physical and mental health and psychosocial concerns of childhood cancer survivors in low- and middle-income countries.
C1 [Prasad, Maya] Tata Mem Hosp, Div Paediat Oncol, Parel, India.
   [Prasad, Maya; Goswami, Savita; Chinnaswamy, Girish; Banavali, Shripad D.; Kurkure, Purna A.] Homi Bhabha Natl Inst HBNI, Anushakti Nagar, India.
   [Goswami, Savita] Tata Mem Hosp, Dept Psycho Oncol, Parel, India.
   [Chinnaswamy, Girish] Tata Mem Hosp, Div Pediat Oncol, Parel, India.
   [Banavali, Shripad D.] Tata Mem Hosp, Dept Med Oncol, Parel, India.
   [Kurkure, Purna A.] Narayana Hlth, SRCC Childrens Hosp, Pediat Oncol & Bone Marrow Transplantat, Mumbai, Maharashtra, India.
C3 Tata Memorial Centre (TMC); Tata Memorial Hospital; Homi Bhabha National
   Institute; Tata Memorial Centre (TMC); Tata Memorial Hospital; Tata
   Memorial Centre (TMC); Tata Memorial Hospital; Tata Memorial Centre
   (TMC); Tata Memorial Hospital
RP Prasad, M (corresponding author), Tata Mem Hosp, Div Paediat Oncol, Parel 400012, India.
EM maya.prasad@gmail.com
OI Kurkure, Purna/0000-0003-4443-2203
CR [Anonymous], The Children's Oncology Group long-term follow-up guidelines for survivors of childhood, adolescent
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NR 39
TC 15
Z9 16
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
EI 2687-8941
J9 JCO GLOB ONCOL
JI JCO Glob. Oncol.
PY 2022
VL 8
AR e2200044
DI 10.1200/GO.22.00044
PG 10
WC Oncology
WE Emerging Sources Citation Index (ESCI)
SC Oncology
GA E3YE0
UT WOS:000974926200022
PM 36332172
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Obayomi, OV
   Olaniran, AF
   Olawoyin, DC
   Falade, OV
   Osemwegie, OO
   Owa, SO
AF Obayomi, Oluwatobi Victoria
   Olaniran, Abiola Folakemi
   Olawoyin, Damilare Cornelius
   Falade, Oyenike Victoria
   Osemwegie, Omorefosa Osarenkhoe
   Owa, Stephen Olugbemiga
TI Role of enteric dysbiosis in the development of central obesity: A
   review
SO SCIENTIFIC AFRICAN
LA English
DT Review
DE Gut; Microbiota; Obesity; Dysbiosis; Diet; Microbiome; Probiotics
ID GUT MICROBIOTA; ERECTILE DYSFUNCTION; ADIPOSE-TISSUE; METABOLIC
   SYNDROME; HUMAN-NUTRITION; HEALTH; CONSEQUENCES; RESISTANCE; MECHANISMS
AB The adipose tissue in a healthy individual is involved in many processes, such as controlling body temperature, energy storage and satiety. An average overweight person can have different fat deposited in target organs or specific body compartments. In the case of pot belly, the accumulation of these fats is in the belly. Central obesity (pot belly) is a result of complex interactions among genetic, environmental, dietary habits, and other lifestyle factors. The gut and enteric microbiota are essential to human health. Each is composed of trillions of bacteria, viruses, and fungi and Impact numerous physiological processes in humans, such as digestion, immune system regulation, metabolism, and even mental health. This depends on the makeup and balance of this microbiota. An increasing number of studies have investigated the connection between health issues like abdominal obesity and the formation of a "pot belly" and the gut microbiota in recent years. It is extremely concerning that this extra fat buildup in the abdomen region is associated with a higher risk of numerous health issues. To address these health issues and develop prevention and treatment strategies such as the use of prebiotics, probiotics, use of antibiotics, it is essential to comprehend the relationship between pot belly and the enteric microbiota. The aim of this review is to deepen our understanding on relationships between alterations in gut microbiota composition and the development of central obesity. Determine how dysbiosis may contribute to metabolic dysregulation, inflammation, and other factors associated with the accumulation of abdominal fat. Explore potential interventions aimed at modulating gut microbiota composition to mitigate central obesity risk. This may include dietary modifications, probiotic or prebiotic supplementation, fecal microbiota transplantation.
C1 [Obayomi, Oluwatobi Victoria; Falade, Oyenike Victoria] Landmark Univ Omu Aran, Dept Food Sci & Nutr, Omu Aran, Kwara State, Nigeria.
   [Olaniran, Abiola Folakemi] Landmark Univ Omu Aran, Food Sci & Nutr Dept, Omu Aran, Kwara State, Nigeria.
   [Olawoyin, Damilare Cornelius; Osemwegie, Omorefosa Osarenkhoe; Owa, Stephen Olugbemiga] Landmark Univ Omu Aran, Dept Microbiol, Omu Aran, Kwara State, Nigeria.
C3 Landmark University; Landmark University; Landmark University
RP Obayomi, OV (corresponding author), Landmark Univ Omu Aran, Dept Food Sci & Nutr, Omu Aran, Kwara State, Nigeria.
EM obayomivictoria06@gmail.com
RI Obayomi, Oluwatobi/KTI-5802-2024; Olaniran, Abiola/ABD-5541-2020; Owa,
   Stephen/AHH-4810-2022
OI Olaniran, Abiola/0000-0001-8212-862X; Obayomi, Oluwatobi
   Victoria/0000-0002-2141-9818
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NR 85
TC 5
Z9 5
U1 2
U2 7
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2468-2276
J9 SCI AFR
JI Sci. Afr.
PD JUN
PY 2024
VL 24
AR e02204
DI 10.1016/j.sciaf.2024.e02204
EA APR 2024
PG 9
WC Multidisciplinary Sciences
WE Emerging Sources Citation Index (ESCI)
SC Science & Technology - Other Topics
GA QK0V0
UT WOS:001220659000001
OA gold
DA 2025-06-11
ER

PT J
AU Wu, H
   Adler, S
   Azagury, DE
   Bohon, C
   Safer, DL
   Barbosa, DAN
   Bhati, MT
   Williams, NR
   Dunn, LB
   Tass, PA
   Knutson, BD
   Yutsis, M
   Fraser, A
   Cunningham, T
   Richardson, K
   Skarpaas, TL
   Tcheng, TK
   Morrell, MJ
   Roberts, LW
   Malenka, RC
   Lock, JD
   Halpern, CH
AF Wu, Hemmings
   Adler, Sarah
   Azagury, Dan E.
   Bohon, Cara
   Safer, Debra L.
   Barbosa, Daniel A. N.
   Bhati, Mahendra T.
   Williams, Nolan R.
   Dunn, Laura B.
   Tass, Peter A.
   Knutson, Brian D.
   Yutsis, Maya
   Fraser, Ayesha
   Cunningham, Tricia
   Richardson, Kara
   Skarpaas, Tara L.
   Tcheng, Thomas K.
   Morrell, Martha J.
   Roberts, Laura Weiss
   Malenka, Robert C.
   Lock, James D.
   Halpern, Casey H.
TI Brain-Responsive Neurostimulation for Loss of Control Eating: Early
   Feasibility Study
SO NEUROSURGERY
LA English
DT Article
DE Responsive neurostimulation; DBS; Deep brain stimulation; Nucleus
   accumbens; Loss of control; Eating disorders; Binge; Obesity
ID BARIATRIC SURGERY; NUCLEUS-ACCUMBENS; STIMULATION; OBESITY; PREVALENCE;
   OVERWEIGHT; DISORDER; WEIGHT; STATES
AB BACKGROUND: Loss of control (LOC) is a pervasive feature of binge eating, which contributes significantly to the growing epidemic of obesity; approximately 80 million US adults are obese. Brain-responsive neurostimulation guided by the delta band was previously found to block binge-eating behavior in mice. Following novel preclinical work and a human case study demonstrating an association between the delta band and reward anticipation, the US Food and Drug Administration approved an Investigational Device Exemption for a first-in-human study.
   OBJECTIVE: To assess feasibility, safety, and nonfutility of brain-responsive neurostimulation for LOC eating in treatment-refractory obesity.
   METHODS: This is a single-site, early feasibility study with a randomized, single-blinded, staggered-onset design. Six subjects will undergo bilateral brain-responsive neurostimulation of the nucleus accumbens for LOC eating using the RNS (R) System (NeuroPace Inc). Eligible participants must have treatment-refractory obesity with body mass index >= 45 kg/m(2). Electrophysiological signals of LOC will be characterized using real-time recording capabilities coupled with synchronized video monitoring. Effects on other eating disorder pathology, mood, neuropsychological profile, metabolic syndrome, and nutrition will also be assessed.
   EXPECTED OUTCOMES: Safety/feasibility of brain-responsive neurostimulation of the nucleus accumbens will be examined. The primary success criterion is a decrease of >= 1 LOC eating episode/week based on a 28-d average in >= 50% of subjects after 6 mo of responsive neurostimulation.
   DISCUSSION: This study is the first to use brain-responsive neurostimulation for obesity; this approach represents a paradigm shift for intractable mental health disorders.
C1 [Wu, Hemmings; Barbosa, Daniel A. N.; Bhati, Mahendra T.; Tass, Peter A.; Cunningham, Tricia; Richardson, Kara; Halpern, Casey H.] Stanford Univ, Dept Neurosurg, Sch Med, 300 Pasteur Dr R-227, Stanford, CA 94305 USA.
   [Wu, Hemmings; Malenka, Robert C.; Halpern, Casey H.] Stanford Univ, Dept Psychiat & Behav Sci, Nancy Pritzker Lab, Sch Med, Stanford, CA 94305 USA.
   [Adler, Sarah; Bohon, Cara; Safer, Debra L.; Bhati, Mahendra T.; Williams, Nolan R.; Dunn, Laura B.; Roberts, Laura Weiss; Malenka, Robert C.; Lock, James D.] Stanford Univ, Dept Psychiat & Behav Sci, Sch Med, Stanford, CA 94305 USA.
   [Azagury, Dan E.] Stanford Univ, Dept Surg, Sch Med, Stanford, CA 94305 USA.
   [Knutson, Brian D.] Stanford Univ, Dept Psychol, Sch Med, Stanford, CA 94305 USA.
   [Yutsis, Maya; Fraser, Ayesha; Cunningham, Tricia; Halpern, Casey H.] Stanford Univ, Dept Neurol & Neurol Sci, Sch Med, Stanford, CA 94305 USA.
   [Skarpaas, Tara L.; Tcheng, Thomas K.; Morrell, Martha J.] NeuroPace Inc, 455 N Bernardo Ave, Mountain View, CA USA.
C3 Stanford University; Stanford University; Stanford University; Stanford
   University; Stanford University; Stanford University
RP Halpern, CH (corresponding author), Stanford Univ, Dept Neurosurg, Sch Med, 300 Pasteur Dr R-227, Stanford, CA 94305 USA.
EM chalpern@stanford.edu
RI Knutson, Brian/A-1217-2007; Tcheng, Thomas/AAA-4901-2021; Williams,
   Nolan/AAG-1221-2019; Tass, Peter/H-8756-2013; Azagury, Dan/H-9507-2019;
   Wu, Hemmings/JMB-7664-2023; Roberts, Laura/Q-3845-2019
OI Roberts, Laura Weiss/0000-0003-4270-253X; Knutson,
   Brian/0000-0002-7669-426X; Morrell, Martha/0000-0001-8157-5313;
   Williams, Nolan/0000-0003-4368-3203; Safer, Debra/0000-0002-9874-2277;
   Bohon, Cara/0000-0001-9978-3727
FU NIH [UH3NS103446-01A1, K12NS080223]; Brain & Behavior Research
   Foundation; Neurosurgery Research and Education Foundation; John A.
   Blume Foundation; William Randolph Hearst Foundation; European Society
   for Stereotactic and Functional Neurosurgery Research Grant; Stanford
   Neuroscience Institute's Neurochoice Initiative; Stanford's Department
   of Neurosurgery; NeuroPace; National Institute of Mental Health;
   National Institute on Aging; National Human Genome Research Institute
FX This study and the preclinical data generated have been supported by NIH
   funds from UH3NS103446-01A1 (C.H.), K12NS080223 (C.H.), the Brain &
   Behavior Research Foundation (C.H.), the Neurosurgery Research and
   Education Foundation (C.H.), the John A. Blume Foundation (C.H.), the
   William Randolph Hearst Foundation (C.H.), the European Society for
   Stereotactic and Functional Neurosurgery Research Grant (H.W.), the
   Stanford Neuroscience Institute's Neurochoice Initiative (C.H.), and
   start-up funds from Stanford's Department of Neurosurgery (C.H.). This
   is an investigator initiated feasibility study; no direct funds were
   received from NeuroPace/industry for this study. Dr Halpern has received
   speaking honoraria for training fellows and other faculty from
   NeuroPace, Medtronic, and Boston Scientific. Dr Tass works as consultant
   for Boston Scientific Neuromodulation and Gretap AG, and is employee
   inventor on a number of patents for invasive and non-invasive
   neuromodulation. Dr Skarpaas and Dr Morrell certify that they have
   equity ownership/stock options with NeuroPace and are employees of
   NeuroPace. Dr Tcheng is an employee of NeuroPace. Dr Williams serves on
   the Scientific Advisory Board for Halo Neuroscience. Dr Roberts is an
   employee of Stanford University. She reports grants from the National
   Institute of Mental Health, the National Institute on Aging, and the
   National Human Genome Research Institute; she serves as the
   Editor-in-Chief, books, for the American Psychiatric Association
   Publishing Division and as Editor-in-Chief of the journal Academic
   Medicine; unrelated to this publication, Dr Roberts serves as an advisor
   for the Bucksbaum Institute of the University of Chicago Pritzker School
   of Medicine and she owns the small business Terra Nova Learning Systems.
   The other authors have no personal, financial, or institutional interest
   in any of the drugs, materials, or devices described in this article.
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   White MA, 2010, J CLIN PSYCHIAT, V71, P175, DOI 10.4088/JCP.08m04328blu
   Whiting DM, 2013, J NEUROSURG, V119, P56, DOI 10.3171/2013.2.JNS12903
   Wu H, 2018, P NATL ACAD SCI USA, V115, P192, DOI 10.1073/pnas.1712214114
NR 40
TC 13
Z9 13
U1 2
U2 12
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0148-396X
EI 1524-4040
J9 NEUROSURGERY
JI Neurosurgery
PD DEC
PY 2020
VL 87
IS 6
BP 1277
EP 1288
DI 10.1093/neuros/nyaa300
PG 12
WC Clinical Neurology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Surgery
GA OX2HH
UT WOS:000593391900071
PM 32717033
OA Green Published
DA 2025-06-11
ER

PT J
AU Srihari, VH
   Phutane, VH
   Ozkan, B
   Chwastiak, L
   Ratliff, JC
   Woods, SW
   Tek, C
AF Srihari, Vinod H.
   Phutane, Vivek H.
   Ozkan, Banu
   Chwastiak, Lydia
   Ratliff, Joseph C.
   Woods, Scott W.
   Tek, Cenk
TI Cardiovascular mortality in schizophrenia: Defining a critical period
   for prevention
SO SCHIZOPHRENIA RESEARCH
LA English
DT Article
DE First episode psychosis; Cardiovascular risk; Cardiovascular mortality;
   Critical period; Early intervention; Schizophrenia
ID EARLY INTERVENTION; HEALTH; PROFILE; ADULTS
AB Objective: Better understanding of the temporal development of cardiovascular risk will permit more targeted prevention of premature cardiovascular mortality in schizophrenia.
   Methods: The sample for this analysis was drawn from referrals (between 2006 and '11) to an early psychosis clinic based in a U. S. urban community mental health center. 76 individuals with schizophrenia who were young (mean 22.4 years, SD 4.8), early course (median duration of illness 31 weeks) and with minimal prior antipsychotic exposure (median 2 weeks) were compared to age-, gender-, and race-matched peers drawn from the National Health and Nutrition Survey (2007-'08). Measures of cardiovascular risk at baseline, 6 months, and 1 year are reported.
   Results: While indistinguishable from peers at entry, patients suffered pervasive adverse trajectories of cardiovascular risk factors over the subsequent year. 16 of 44 initial non-smokers became nicotine dependent and none of 32 entering smokers quit. 17 patients transitioned to overweight (BMI 25-29.9, n=3) or obese (BMI>30, n=14) categories, while only 24 of 38 (63%) sustained normal weight over one year. Similar adverse trends in blood pressure, lipids, and fasting glucose led to an increase in prevalence of metabolic syndrome (1.31% to 5.26%). 10-year cardiovascular risk estimates showed a small and significant increase although remaining in the low risk (<10%) category.
   Conclusions: The early emergence of obesity and smoking in younger schizophrenia samples provides a rational focus for primary prevention of premature cardiovascular mortality. The first year of treatment constitutes the beginning of a critical period for such preventive efforts. (C) 2013 Elsevier B.V. All rights reserved.
C1 [Srihari, Vinod H.; Phutane, Vivek H.; Ozkan, Banu; Ratliff, Joseph C.; Woods, Scott W.; Tek, Cenk] Yale Univ, Dept Psychiat, New Haven, CT 06520 USA.
   [Chwastiak, Lydia] Univ Washington, Dept Psychiat & Behav Sci, Seattle, WA 98195 USA.
C3 Yale University; University of Washington; University of Washington
   Seattle
RP Srihari, VH (corresponding author), Connecticut Mental Hlth Ctr, 34 Pk St,2nd Floor Mailroom, New Haven, CT 06519 USA.
EM v.h.srihari@gmail.com
RI Woods, Scott/AAF-4811-2020; Tek, Cenk/M-1552-2019; Srihari,
   Vinod/B-9040-2018
OI Srihari, Vinod/0000-0003-1556-2332
FU National Institutes of Health [MH088971]; Donaghue Foundation
   [DF07-014]; National Institute of Health (NIH) [1RC1MH088971-01, 5R01
   MH80048-2/AS0002]
FX This work was supported by the National Institutes of Health (MH088971
   to VHS) and a grant from the Donaghue Foundation (DF07-014 to VHS). The
   Specialized Treatment Early in Psychosis (STEP) Program is supported by
   The Donaghue Foundation Grant number DF07-014 (Srihari, PI) and by the
   National Institute of Health (NIH), Grant number 1RC1MH088971-01
   (Srihari, PI). Both The Donaghue Foundation and the NIH had no further
   role in the study design, in the collection, analysis and interpretation
   of data; in the writing of the report; and in the decision to submit the
   paper for publication. Dr. Tek's work on this project is supported by
   the National Institute of Health (NIH), Grant number 5R01
   MH80048-2/AS0002.
CR Amer Diabet Assoc, 2010, DIABETES CARE, V33, pS11, DOI [10.2337/dc10-S011, 10.2337/dc10-S062, 10.2337/dc13-S011, 10.2337/dc13-S067, 10.2337/dc11-S011, 10.2337/dc14-S081, 10.2337/dc12-s064, 10.2337/dc11-S062, 10.2337/dc12-s011]
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NR 26
TC 46
Z9 47
U1 1
U2 33
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0920-9964
EI 1573-2509
J9 SCHIZOPHR RES
JI Schizophr. Res.
PD MAY
PY 2013
VL 146
IS 1-3
BP 64
EP 68
DI 10.1016/j.schres.2013.01.014
PG 5
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 122RU
UT WOS:000317336500011
PM 23422728
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Wang, XL
   Guo, LF
   Liu, GY
   Liu, TZ
AF Wang, Xiaolong
   Guo, Linfa
   Liu, Guiyong
   Liu, Tongzu
TI Leptin Mediates Prostate Stromal Cell Proliferation, Smooth Muscle
   Contraction, and Mitochondrial Function in Benign Prostate Hyperplasia
SO DIABETES METABOLIC SYNDROME AND OBESITY
LA English
DT Article
DE metabolic syndrome; leptin; prostate; contraction; mitochondrial
ID GROWTH
AB Introduction: Leptin is a metabolic peptide hormone produced by adipocytes, with proven roles in proliferation of prostate cancer cells and of prostate cells in animal models of benign prostatic hyperplasia (BPH). Thus, the role of leptin as a molecular link connecting BPH and lower urinary tract symptoms (LUTS) suggestive of BPH with metabolic symptoms appears feasible but is still unknown. In fact, a connection between metabolic syndrome and BPH is becoming increasingly evident from epidemiologic studies. Key factors of Lower urinary tract symptoms associated with benign prostatic hyperplasia (BPH/LUTS) are increased prostate smooth muscle tone, and prostate enlargement. Here, we examined the effects of leptin on contraction of human prostate smooth muscle and on growth of stromal cells.Methods: We performed microarray analysis to identify genes (fold change >= 1.5) associated with BPH/LUTS progression, such as those involved in proliferation, apoptosis, and mitochondrial metabolism, in rat prostate tissue (data from GSE129561). We then used electric field stimulation (EFS) to induce frequency-dependent, neurogenic contractions of human prostate strips, which were enhanced by leptin. We also examined the effect of leptin on human prostate stromal cells (WPMY-1) and found increased cell proliferation and viability upon exposure. To explore the underlying mechanism, we conducted mitochondrial stress assay using near-infrared (NIR) fluorescent dye and flow cytometry (FACS) analysis and observed reduced cellular apoptosis and preserved mitochondrial membrane potential ( increment psi M) after leptin treatment.Results: Microarray analysis reveals that leptin regulates prostate smooth muscle contraction and stromal cell proliferation, shedding new light on its involvement in BPH/LUTS pathogenesis and mitochondrial function. We found that leptin enhanced the proliferation rate of prostate stromal cells relative to the control group (0.67 +/- 0.05 vs 0.54 +/- 0.08, p-value= 0.024). Moreover, leptin (100 ng/mL) potentiated the frequency-dependent, neurogenic contractions of prostate strips elicited by EFS (p= 0.047 between leptin and control group). We also show that leptin treatment increased the mitochondrial membrane potential of prostate stromal cells and inhibited mitochondrial apoptosis.Discussion: Our results indicate that leptin stimulates the contractility and proliferation of smooth muscle and stromal cells in the human prostate, implying a potential role for leptin in exacerbating BPH/LUTS in obese men. Leptin modulation may be a beneficial therapeutic strategy for patients with metabolic syndrome and BPH/LUTS. Further studies are warranted to elucidate the mechanisms and implications of the leptin system in BPH/LUTS.
C1 [Wang, Xiaolong; Guo, Linfa; Liu, Tongzu] Wuhan Univ, Zhongnan Hosp, Dept Urol, Wuhan, Peoples R China.
   [Liu, Guiyong] Qianjiang Cent Hosp Hubei Prov, Qianjiang, Peoples R China.
   [Liu, Tongzu] Canc Precis Diag & Treatment & Translat Med Hubei, Wuhan, Peoples R China.
   [Liu, Tongzu] Hubei Prov Key Lab Urinary Syst Dis, Wuhan, Peoples R China.
   [Liu, Guiyong; Liu, Tongzu] Wuhan Univ, Canc Precis Diag & Treatment & Translat Med Hubei, Dept Urol, Zhongnan Hosp,Hubei Prov Key Lab Urinary Syst Dis, Wuhan 430071, Peoples R China.
C3 Wuhan University; Wuhan University
RP Liu, GY; Liu, TZ (corresponding author), Wuhan Univ, Canc Precis Diag & Treatment & Translat Med Hubei, Dept Urol, Zhongnan Hosp,Hubei Prov Key Lab Urinary Syst Dis, Wuhan 430071, Peoples R China.
EM nogardmd@whu.edu.cn; liutongzu@163.com
RI WANG, XIAOLONG/AAA-4301-2022
FU Li Huanying Foundation of Beijing, 2020 [PYZ201503]; China Scholarship
   Council [201606270233]; Li Huanying Foundation of Beijing, 2020
   [PYZ201503]; China Scholarship Council [201606270233]
FX This analysis and/or the underlying studies had been funded by the Li
   Huanying Foundation of Beijing, 2020, NO. PYZ201503 and the China
   Scholarship Council (grant 201606270233 (WXL)). Both funding sources
   were not involved in study design, in collection, analysis and
   interpretation of data, in the writing of the report, or in the decision
   to submit the article for publication.
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NR 27
TC 1
Z9 1
U1 0
U2 5
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-7007
J9 DIABET METAB SYND OB
JI Diabetes Metab. Syndr. Obes.
PY 2023
VL 16
BP 3261
EP 3273
DI 10.2147/DMSO.S420258
PG 13
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA U9MC5
UT WOS:001087964700001
PM 37876983
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Michael, S
   MacDonald, K
AF Michael, Sarah
   MacDonald, Kirsty
TI Improving rates of metabolic monitoring on an inpatient psychiatric ward
SO BMJ OPEN QUALITY
LA English
DT Article
DE chronic disease management; coronary disease; healthcare quality
   improvement; mental health; nurses
ID LIFE EXPECTANCY; SCHIZOPHRENIA; PREVALENCE; RISK; MANAGEMENT;
   OUTPATIENTS; MORTALITY; CARE
AB ObjectivesCardiovascular disease is the leading cause of premature death in patients with mental illness. Metabolic syndrome is a cluster of co-occurring cardiovascular risk factors, seen in high frequency in severe mental illness. Despite ease of diagnosis, monitoring is often poor across psychiatric populations. This report details a quality improvement initiative undertaken on an inpatient psychiatric ward to improve rates of metabolic monitoring.MethodsFour key interventions were developed: (1) A nurse-led intervention, where nurses were upskilled in performing metabolic monitoring, (2) Education was provided to all staff, (3) Introduction of a suite of interventions to improve metabolic risk and (4) Ongoing consumer involvement. A pre-post intervention study design was used to measure effectiveness, with an audit of metabolic monitoring rates performed 12 months after the intervention began.ResultsRates of weight and height monitoring both increased from 46.0% to 69.5% (p=0.0185) and body mass index (BMI) recordings increased from 33% to 63% (p=0.0031). Rates of waist circumference monitoring increased from 44.2% to 65.2% (p=0.0498). Blood pressure (BP) measurements increased from 88.5% to 100% (p=0.0188). Lipid monitoring rates improved from 23% to 69.5% (p=0.001). Rates of glucose monitoring increased from 74% to 82.5% (p=0.8256), although this was not statistically significant.ConclusionsWe found that metabolic monitoring improved following these simple interventions, with a statistically significant increase in measurement rates of weight, BP, height, lipids, BMI and waist circumference (p<0.05). Overall monitoring of glucose also improved, although not to significant levels. The intervention was acceptable to both patients and staff.
C1 [Michael, Sarah] St Vincents Hosp Sydney, Mental Hlth Serv, Darlinghurst, NSW, Australia.
   [Michael, Sarah] Univ New South Wales, Sch Med, Sydney, NSW, Australia.
   [MacDonald, Kirsty] Justice Hlth & Forens Mental Hlth Network, Matraville, NSW, Australia.
C3 NSW Health; St Vincents Hospital Sydney; University of New South Wales
   Sydney
RP Michael, S (corresponding author), St Vincents Hosp Sydney, Mental Hlth Serv, Darlinghurst, NSW, Australia.; Michael, S (corresponding author), Univ New South Wales, Sch Med, Sydney, NSW, Australia.
EM sarah.michael1@svha.org.au
OI Michael, Sarah/0000-0002-8238-847X
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NR 40
TC 9
Z9 11
U1 0
U2 3
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
EI 2399-6641
J9 BMJ OPEN QUAL
JI BMJ Open Qual.
PD SEP
PY 2020
VL 9
IS 3
AR e000748
DI 10.1136/bmjoq-2019-000748
PG 8
WC Health Care Sciences & Services; Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC Health Care Sciences & Services; General & Internal Medicine
GA TI1NM
UT WOS:000672549900002
PM 32699081
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Consolazio, D
   AlSayed, A
   Serini, M
   Benassi, D
   Sarti, S
   Terraneo, M
   Celata, C
   Russo, AG
AF Consolazio, David
   AlSayed, Ahmed
   Serini, Miriam
   Benassi, David
   Sarti, Simone
   Terraneo, Marco
   Celata, Corrado
   Russo, Antonio Giampiero
TI Social inequalities in health within the City of Milan (Lombardy Region,
   Northern Italy): An ecological assessment
SO EPIDEMIOLOGIA & PREVENZIONE
LA English
DT Article
DE health inequalities; social determinants of health; ecological analysis;
   disease mapping; social epidemiology
ID NEIGHBORHOOD DEPRIVATION; MENTAL-HEALTH; CONTEXT; CLASSIFICATION;
   UNEMPLOYMENT; DISADVANTAGE; ENVIRONMENT; INDICATORS; MORTALITY; MODELS
AB Objectives: to document existing geographical inequalities in health in the city of Milan (Lombardy Region, Northern Italy), examining the association between area socioeconomic disadvantage and health outcomes, with the aim to suggest policy action to tackle them. Design: the analysis used an ecological framework; multiple health indicators were considered in the analysis; socioeconomic disadvantage was measured through indicators such as low education, unemployment, immigration status, and housing crowding. For each municipal statistical area, Bayesian Relative Risks of the outcomes (using the Besag-Yorkand-Molli & eacute; model) were plotted on the city map. To evaluate the association between social determinants and health outcomes, Spearman correlation coefficients were estimated. Setting and participants: residents in the City of Milan aged between 30 and 75 years who were residing in Milan as of 01.01.2019, grouped in 88 statistical areas. Main outcomes measures: all-cause mortality, type-2 diabetes mellitus, hypertension, neoplasms, respiratory diseases, metabolic syndrome, antidepressants use, polypharmacy, and multimorbidity. Results: the results consistently demonstrated a significant association between socioeconomic disadvantage and various health outcomes, with low education exhibiting the strongest correlations. Neoplasms displayed an inverse social gradient, while the relationship with antidepressant use varied. Conclusions: these findings provide valuable insights into the distribution of health inequalities in Milan and contribute to the existing literature on the social determinants of health. The study highlights the need for targeted interventions to address disparities and promote equitable health outcomes. The results can serve to inform the development of effective public health strategies and policies aimed at reducing health inequalities in the city.
C1 [Consolazio, David; Russo, Antonio Giampiero] Agcy Hlth Protect Metropolitan City Milan, Epidemiol Unit, Milan, Italy.
   [Consolazio, David; Serini, Miriam; Benassi, David; Terraneo, Marco] Univ Milano Bicocca, Dept Sociol & Social Res, Milan, Italy.
   [AlSayed, Ahmed; Sarti, Simone] Univ Milan, Dept Social & Polit Sci, Milan, Italy.
   [Celata, Corrado] Agcy Hlth Protect Metropolitan City Milan, Specif Prevent Unit, Milan, Italy.
C3 University of Milano-Bicocca; University of Milan
RP Russo, AG (corresponding author), Agcy Hlth Protect Metropolitan City Milan, Epidemiol Unit, Milan, Italy.
EM agrusso@ats-milano.it
RI Terraneo, Marco/AFT-7764-2022; Russo, Antonio/K-2230-2018; BENASSI,
   DAVID/AFZ-1806-2022
OI Russo, Antonio Giampiero/0000-0002-5681-5861
FU Fondazione Cariplo [2020-4269]
FX Fundings: this study has been conducted in the context of the project
   'Enhancing healthcare and well-being through the potential of big data:
   an integration of survey, administrative, and open data to assess health
   risk in the City of Milan with data science' (Project Code 2020-4269)
   funded by Fondazione Cariplo (https://
   www.fondazionecariplo.it/en/index.html) within the call 'Data Science
   for science and society'. The funder had no role in study design, data
   collection and analysis, decision to publish, or preparation of the
   manuscript.
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NR 70
TC 2
Z9 2
U1 0
U2 0
PU INFERENZE SCARL
PI MILANO
PA VIA RICCIARELLI N 29, MILANO, 20148, ITALY
SN 1120-9763
EI 2385-1937
J9 EPIDEMIOL PREV
JI Epidemiol. Prev.
PD JUL-OCT
PY 2024
VL 48
IS 4-5
BP 298
EP 308
DI 10.19191/EP24.4-5.A741.072
PG 11
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA K4B2C
UT WOS:001343335700008
PM 39206587
DA 2025-06-11
ER

PT J
AU Rarrick, C
   Saccone, N
   Hebbard, A
   Jones, B
AF Rarrick, Christine
   Saccone, Nicole
   Hebbard, Amy
   Jones, Brittany
TI Assessing the Rate of Antipsychotic Use in Ambulatory Care Patients With
   a Venous Thromboembolism
SO ANNALS OF PHARMACOTHERAPY
LA English
DT Article
DE antipsychotics; antipsychotics (atypical); ambulatory care; drug safety;
   neuroleptics; mental health; psychiatry
ID INCREASED RISK; METABOLIC SYNDROME; DRUG EXPOSURE; ASSOCIATION
AB Background: Evidence regarding the use of antipsychotics and associated venous thromboembolism (VTE) risk is inconclusive. Studies finding a relationship lack in-depth analysis; thus, the VTE risk among those treated with antipsychotic remains largely unknown. Objectives: The primary objective of this investigation was to compare the incidence of antipsychotic use in patients who developed a VTE versus those who did not. Methods: Data were collected via retrospective chart review from an ambulatory care clinic between January 2012 and August 2017. All active clinic patients within the study period were included unless they met the following criteria: age <18 years, pregnancy within the study period, and/or current or historical malignancy. The odds ratio (OR) of developing a VTE was determined using multivariate regression analysis controlling for age, gender, obesity, and smoking. Secondary end points were reviewed for participants who were exposed to an antipsychotic and subsequently developed a VTE within the study period. Results: A total of 7079 patients were included in the analysis, of whom 314 developed a VTE. Of these, 45 were exposed to an antipsychotic prior to VTE development. Nearly 25% of patients receiving an antipsychotic did not have a primary psychiatric diagnosis. Results suggest that antipsychotic use was significantly associated with increased risk of VTE development (OR = 1.481 [95% CI = 1.067 to 2.055]). Conclusion and Relevance: The results of this study suggest an association between antipsychotic use and VTE development. This association should be considered when prescribing antipsychotics and treating patients who develop a VTE after antipsychotic exposure.
C1 [Rarrick, Christine; Saccone, Nicole; Hebbard, Amy; Jones, Brittany] MUSC, Charleston, SC USA.
C3 Medical University of South Carolina
RP Rarrick, C (corresponding author), 67 President St Room,448N, Charleston, SC 29425 USA.
EM cmrarrick@gmail.com
OI Rarrick, Christine/0000-0002-8906-9332
CR Ageno W, 2014, ARTERIOSCL THROM VAS, V34, P2478, DOI 10.1161/ATVBAHA.114.304085
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NR 29
TC 3
Z9 3
U1 0
U2 0
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1060-0280
EI 1542-6270
J9 ANN PHARMACOTHER
JI Ann. Pharmacother.
PD FEB
PY 2020
VL 54
IS 2
BP 97
EP 104
AR 1060028019870874
DI 10.1177/1060028019870874
EA AUG 2019
PG 8
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA JY1MN
UT WOS:000483844300001
PM 31416330
DA 2025-06-11
ER

PT J
AU Profenno, LA
   Faraone, SV
AF Profenno, Louis A.
   Faraone, Stephen V.
TI Diabetes and overweight associatewith non-APOE4 genotype in an
   Alzheimer's disease population
SO AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
LA English
DT Article
DE dementia; obesity; insulin; diuretic
ID VASCULAR RISK-FACTORS; BODY-MASS INDEX; ANTIHYPERTENSIVE-MEDICATION-USE;
   APOLIPOPROTEIN-E GENOTYPE; RETINOL-BINDING-PROTEIN; CACHE COUNTY;
   METABOLIC SYNDROME; OLDER-ADULTS; WEIGHT-LOSS; APOE GENE
AB Type 2 diabetes is a risk factor for late-onset Alzheimer's disease (AD), and studies suggest that pathogenic effects of diabetes and insulin resistance may be associated with non-APOE4 AD. Therefore, we examined association of the APOE4 allele with diabetes in an AD population. Retrospective and cross-sectional clinical and APOE-genotype data on 465 cases with probable or definite AD previously ascertained by the National Institute of Mental Health Genetics Initiative were analyzed by regression analysis. Dependent variables included presence of APOE4 alleles and AD onset age. Diabetes was the independent variable and covariates included gender, hypertension, and other potentially confounding variables. We also examined for interactions involving weight status as overweight and obesity are independent risk factors for insulin resistance, diabetes and AD. Prevalence of diabetes was 13% among AD cases without an APOE4 allele and 5-6% among AD cases with one or two APOE4 alleles. Odds ratio for diabetes was 0.26 [95% CI: 0.09-0.73;P = 0.011] by APOE4 status after adjusting for all covariates. Diabetes did not associate with AD onset age. Among other independent variables included in the model, APOE4 and diuretic medication treatment were associated with AD onset age. In a subset of cases with body mass index determinations, overweight also exhibited an inverse association with APOE4 and associated with decreased non-APOE4 AD onset age. Pathogenic mechanisms associated with diabetes and overweight are enriched in AD cases without an APOE4 allele. (c) 2008 Wiley-Liss, Inc.
C1 [Profenno, Louis A.] SUNY Upstat Med Univ, Dept Psychiat & Behav Sci, Syracuse VA Med Ctr, Syracuse, NY 13210 USA.
C3 Syracuse University; State University of New York (SUNY) System; State
   University of New York (SUNY) Upstate Medical Center
RP Profenno, LA (corresponding author), SUNY Upstat Med Univ, Dept Psychiat & Behav Sci, Syracuse VA Med Ctr, 750 E Adams St, Syracuse, NY 13210 USA.
EM profennl@upstate.edu
RI Faraone, Stephen/G-5785-2010; Faraone, Stephen V/O-7239-2018
OI Faraone, Stephen V/0000-0002-9217-3982
FU NIMH NIH HHS [U01 MH46373, U01 MH46290, U01 MH46281] Funding Source:
   Medline
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NR 64
TC 32
Z9 33
U1 0
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1552-4841
EI 1552-485X
J9 AM J MED GENET B
JI Am. J. Med. Genet. B
PD SEP 5
PY 2008
VL 147B
IS 6
BP 822
EP 829
DI 10.1002/ajmg.b.30694
PG 8
WC Genetics & Heredity; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Genetics & Heredity; Psychiatry
GA 346EB
UT WOS:000259050100022
PM 18189240
DA 2025-06-11
ER

PT J
AU Pistollato, F
   Burkhart, G
   Deceuninck, P
   Bernasconi, C
   Di Virgilio, S
   Emili, L
   Fauvel, AC
   Bastos, LF
   Gastaldello, A
   Gerardi, C
   Habermann, JK
   Hanes, I
   Kyriakopoulou, C
   Lanka, U
   Lauriola, P
   Laverty, H
   Maisonneuve, BGC
   Mennecozzi, M
   Pappalardo, F
   Pastorino, R
   Radvilaite, V
   Roggen, EL
   Constantino, H
AF Pistollato, Francesca
   Burkhart, Gregor
   Deceuninck, Pierre
   Bernasconi, Camilla
   Di Virgilio, Sergio
   Emili, Luca
   Fauvel, Anne-Charlotte
   Bastos, Luisa Ferreira
   Gastaldello, Annalisa
   Gerardi, Chiara
   Habermann, Jens K.
   Hanes, Ioan
   Kyriakopoulou, Christina
   Lanka, Uma
   Lauriola, Paolo
   Laverty, Hugh
   Maisonneuve, Benoit G. C.
   Mennecozzi, Milena
   Pappalardo, Francesco
   Pastorino, Roberta
   Radvilaite, Vilma
   Roggen, Erwin L.
   Constantino, Helder
TI What public health challenges and unmet medical needs would benefit from
   interdisciplinary collaboration in the EU? A survey and
   multi-stakeholder debate
SO FRONTIERS IN PUBLIC HEALTH
LA English
DT Review
DE public health; biomedical research; patient-centric research; societal
   impact; policy; translatability; funding; research innovative
   methodologies
ID CLINICAL-TRIALS; LIMITATIONS
AB In the past decade, significant European calls for research proposals have supported translational collaborative research on non-communicable and infectious diseases within the biomedical life sciences by bringing together interdisciplinary and multinational consortia. This research has advanced our understanding of disease pathophysiology, marking considerable scientific progress. Yet, it is crucial to retrospectively evaluate these efforts' societal impact. Research proposals should be thoughtfully designed to ensure that the research findings can be effectively translated into actionable policies. In addition, the choice of scientific methods plays a pivotal role in shaping the societal impact of research discoveries. Understanding the factors responsible for current unmet public health issues and medical needs is crucial for crafting innovative strategies for research policy interventions. A multistakeholder survey and a roundtable helped identify potential needs for consideration in the EU research and policy agenda. Based on survey findings, mental health disorders, metabolic syndrome, cancer, antimicrobial resistance, environmental pollution, and cardiovascular diseases were considered the public health challenges deserving prioritisation. In addition, early diagnosis, primary prevention, the impact of environmental pollution on disease onset and personalised medicine approaches were the most selected unmet medical needs. Survey findings enabled the formulation of some research-policies interventions (RPIs), which were further discussed during a multistakeholder online roundtable. The discussion underscored recent EU-level activities aligned with the survey-derived RPIs and facilitated an exchange of perspectives on public health and biomedical research topics ripe for interdisciplinary collaboration and warranting attention within the EU's research and policy agenda. Actionable recommendations aimed at facilitating the translation of knowledge into transformative, science-based policies are also provided.
C1 [Pistollato, Francesca; Constantino, Helder] Humane Soc Int, Res & Toxicol, Brussels, Belgium.
   [Burkhart, Gregor] European Monitoring Ctr Drugs & Drug Addict EMCDDA, Lisbon, Portugal.
   [Deceuninck, Pierre; Bernasconi, Camilla; Gastaldello, Annalisa; Mennecozzi, Milena] European Commiss, Joint Res Ctr JRC, Ispra, Italy.
   [Di Virgilio, Sergio; Kyriakopoulou, Christina] European Commiss, Res & Innovat R&I, Brussels, Belgium.
   [Emili, Luca] InSilicoTrials Technol, Milan, Italy.
   [Fauvel, Anne-Charlotte] European Infrastruct Translat Med, Amsterdam, Netherlands.
   [Bastos, Luisa Ferreira] Eurogrp Anim, Brussels, Belgium.
   [Gerardi, Chiara] Mario Negri Inst Pharmacol Res IRCCS, Ctr Hlth Regulatory Policies, Milan, Italy.
   [Habermann, Jens K.] Biobanking & Biomol Resources Res Infrastruct Cons, BBMRI ERIC, Graz, Austria.
   [Hanes, Ioan] European Lifestyle Med Org, Geneva, Switzerland.
   [Lanka, Uma] Humane Soc Int, Res & Toxicol, London, England.
   [Lauriola, Paolo] Int Soc Doctors Environm, Modena, Italy.
   [Laverty, Hugh] Innovat Hlth Initiat, Brussels, Belgium.
   [Maisonneuve, Benoit G. C.] NETRI Digitizing Human Biol, Lyon, France.
   [Pappalardo, Francesco] Univ Catania, Dept Drug & Hlth Sci, Catania, Italy.
   [Pastorino, Roberta] Univ Cattolica Sacro Cuore, Dept Life Sci & Publ Hlth, Sect Hyg, Rome, Italy.
   [Radvilaite, Vilma] European Innovat Council, Brussels, Belgium.
   [Roggen, Erwin L.] ToxGenSolut & 3Rs Management & Consulting ApS, Maastricht, Netherlands.
C3 European Commission Joint Research Centre; EC JRC ISPRA Site; Vrije
   Universiteit Amsterdam; Istituto di Ricerche Farmacologiche Mario Negri
   IRCCS; University of Catania; Catholic University of the Sacred Heart;
   IRCCS Policlinico Gemelli
RP Pistollato, F (corresponding author), Humane Soc Int, Res & Toxicol, Brussels, Belgium.
EM fpistollato@hsi.org
RI Gerardi, Chiara/AAA-6718-2020; Habermann, Jens/E-2968-2010; PASTORINO,
   Roberta/AAC-1866-2022; Pappalardo, Francesco/C-5832-2011
FX The author(s) declare that no financial support was received for the
   research, authorship, and/or publication of this article.
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NR 115
TC 1
Z9 1
U1 4
U2 6
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 2296-2565
J9 FRONT PUBLIC HEALTH
JI Front. Public Health
PD JUL 22
PY 2024
VL 12
AR 1417684
DI 10.3389/fpubh.2024.1417684
PG 24
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA A7Q2N
UT WOS:001284439400001
PM 39104886
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Ranjan, P
   Vikram, NK
   Choranur, A
   Pradeep, Y
   Ahuja, M
   Meeta, M
   Puri, M
   Malhotra, A
   Kumari, A
   Chopra, S
   Batra, A
   Balsalkar, G
   Goswami, D
   Guleria, K
   Sarkar, S
   Kachhawa, G
   Verma, A
   Kumari, MK
   Madan, J
   Dabral, A
   Kamath, S
   Rathore, AM
   Kumar, R
   Venkataraman, S
   Kaloiya, G
   Bhatla, N
   Kumari, SS
   Baitha, U
   Prakash, A
   Tiwaskar, M
   Tewary, K
   Misra, A
   Guleria, R
AF Ranjan, Piyush
   Vikram, Naval Kishore
   Choranur, Ambuja
   Pradeep, Yashodhara
   Ahuja, Maninder
   Meeta, Meeta
   Puri, Manju
   Malhotra, Anita
   Kumari, Archana
   Chopra, Sakshi
   Batra, Achla
   Balsalkar, Geetha
   Goswami, Deepti
   Guleria, Kiran
   Sarkar, Siddharth
   Kachhawa, Garima
   Verma, Aditi
   Kumari, M. Krishna
   Madan, Jagmeet
   Dabral, Anjali
   Kamath, Sandhya
   Rathore, Asmita Muthal
   Kumar, Raman
   Venkataraman, Srikumar
   Kaloiya, Gaurishankar
   Bhatla, Neerja
   Kumari, S. Shantha
   Baitha, Upendra
   Prakash, Anupam
   Tiwaskar, Mangesh
   Tewary, Kamlesh
   Misra, Anoop
   Guleria, Randeep
TI Executive Summary of Evidence and Consensus-Based Clinical Practice
   Guidelines for Management of Obesity and Overweight in Midlife Women: An
   AIIMS-DST Initiative
SO JOURNAL OF MID-LIFE HEALTH
LA English
DT Review
DE Behavioral modification; diet; exercise; menopausal transition; midlife;
   weight
ID LIFE-STYLE INTERVENTION; WEIGHT-LOSS; PHYSICAL-ACTIVITY; POSTMENOPAUSAL
   WOMEN; BODY-COMPOSITION; EXERCISE INTERVENTION; CARDIOVASCULAR RISK;
   METABOLIC SYNDROME; AMERICAN-COLLEGE; DIET
AB Weight gain is an independent risk factor for decline in cardiometabolic and overall health-related quality of life in midlife women. The AIIMS-DST initiative aims to develop and validate stepwise recommendations specific for weight management in midlife women. The key clinical questions specific to weight management in midlife women were finalized with the help of a multidisciplinary team of experts in the guideline development group. Phase I including a systematic and/or narrative review, grading of evidence, and expert opinion was sought to develop clinical practice recommendations for each clinical question. Phase II focused on validation of clinical practice recommendations using the peer-review, Delphi method, and GRADE approach. The guidelines provide clinical practice points to address challenges encountered by midlife women in their attempts to manage obesity via lifestyle modification techniques. The initiation of discussion would help the health-care provider to identify the weight management needs of the women, educate women on different modalities of weight management, and empower them to incorporate corrective lifestyle behaviors. Before initiating the management, a comprehensive assessment of clinical and lifestyle-related parameters should be completed. A personalized behavioral lifestyle modification program addressing the midlife-specific barriers for optimal metabolic, musculoskeletal, and mental health should be planned. A consistent follow-up is required for maintenance of corrective eating and activity habits by addressing midlife-specific barriers for sustenance of healthy weight. These recommendations will be useful in opportunistic screening and management of obesity in midlife women across health-care settings.
C1 [Ranjan, Piyush; Vikram, Naval Kishore; Baitha, Upendra] All India Inst Med Sci, Dept Med, New Delhi 110029, India.
   [Kumari, Archana; Batra, Achla; Kachhawa, Garima; Bhatla, Neerja] All India Inst Med Sci, Dept Obstet & Gynaecol, New Delhi, India.
   [Sarkar, Siddharth; Kaloiya, Gaurishankar] All India Inst Med Sci, Dept Psychiat, New Delhi, India.
   [Venkataraman, Srikumar] All India Inst Med Sci, Dept Phys Med & Rehabil, New Delhi, India.
   [Guleria, Randeep] All India Inst Med Sci, New Delhi, India.
   [Puri, Manju] LHMC & SSK Hosp, Dept Obstet & Gynaecol, New Delhi, India.
   [Batra, Achla] Assoc Obstetricians & Gynaecologists Delhi AOGD, New Delhi, India.
   [Batra, Achla; Dabral, Anjali] VMMC & Safdarjung Hosp, Dept Obstet & Gynaecol, New Delhi, India.
   [Goswami, Deepti] Maulana Azad Med Coll, Dept Obstet & Gynaecol, New Delhi, India.
   [Guleria, Kiran; Rathore, Asmita Muthal] Univ Coll Med Sci, Dept Obstet & Gynaecol, New Delhi, India.
   [Kumar, Raman] Acad Family Phys India, New Delhi, India.
   [Prakash, Anupam] LHMC & SSK Hosp, Dept Med, New Delhi, India.
   [Misra, Anoop] Fortis C DOC Ctr Excellence Diabet Metab Dis & En, Lucknow, Uttar Pradesh, India.
   [Misra, Anoop] Natl Diabet Obes & Cholesterol Fdn N DOC, Lucknow, Uttar Pradesh, India.
   [Misra, Anoop] Diabet Fdn India, Lucknow, Uttar Pradesh, India.
   [Pradeep, Yashodhara] Era Med Coll & Univ, Dept Obstet & Gynaecol, Lucknow, Uttar Pradesh, India.
   [Pradeep, Yashodhara] KGMU, RML Inst Med Sci, Dept Obstet & Gynaecol, Lucknow, Uttar Pradesh, India.
   [Malhotra, Anita] Univ Delhi, Lakshmibai Coll, Dept Home Sci, Delhi, India.
   [Chopra, Sakshi; Verma, Aditi] Univ Delhi, Dept Home Sci, Delhi, India.
   [Balsalkar, Geetha] Seth GS Med Coll, Dept Obstet & Gynaecol, Mumbai, Maharashtra, India.
   [Kamath, Sandhya] LT Municipal Med Coll & Gen Hosp, Med, Mumbai, Maharashtra, India.
   [Kamath, Sandhya] LT Municipal Med Coll & Gen Hosp, Mumbai, Maharashtra, India.
   [Kamath, Sandhya] Seth GS Med Coll & KEM Hosp, Med, Mumbai, Maharashtra, India.
   [Kamath, Sandhya] Seth GS Med Coll & KEM Hosp, Mumbai, Maharashtra, India.
   [Pradeep, Yashodhara; Kumari, S. Shantha] Federat Obstet & Gynaecol Soc India, Mumbai, Maharashtra, India.
   [Kumari, M. Krishna] Apollo Med Coll, Dept Obstet & Gynaecol, Hyderabad, Telangana, India.
   [Choranur, Ambuja] Indian Menopause Soc, Hyderabad, India.
   [Choranur, Ambuja] Osmania Med Coll & Hosp, Dept Obstet & Gynaecol, Hyderabad, India.
   [Ahuja, Maninder] Soc Meaningful Life Management, Faridabad, India.
   [Madan, Jagmeet] Indian Dietet Assoc, Mumbai, Maharashtra, India.
   [Tiwaskar, Mangesh; Tewary, Kamlesh] Assoc Phys India, Mumbai, Maharashtra, India.
C3 All India Institute of Medical Sciences (AIIMS) New Delhi; All India
   Institute of Medical Sciences (AIIMS) New Delhi; All India Institute of
   Medical Sciences (AIIMS) New Delhi; All India Institute of Medical
   Sciences (AIIMS) New Delhi; All India Institute of Medical Sciences
   (AIIMS) New Delhi; Lady Hardinge Medical College & Hospital; Vardhman
   Mahavir Medical College & Safdarjung Hospital; Maulana Azad Medical
   College; University of Delhi; University College of Medical Sciences;
   Lady Hardinge Medical College & Hospital; King George's Medical
   University; University of Delhi; University of Delhi; Seth Gordhandas
   Sunderdas Medical College & King Edward Memorial Hospital; Seth
   Gordhandas Sunderdas Medical College & King Edward Memorial Hospital;
   Seth Gordhandas Sunderdas Medical College & King Edward Memorial
   Hospital
RP Vikram, NK (corresponding author), All India Inst Med Sci, Dept Med, New Delhi 110029, India.
EM navalvikram@gmail.com
RI Venkataraman, Srikumar/JQV-8304-2023; Tiwaskar, Mangesh/AAE-6002-2020
OI Malhotra, Anita/0000-0001-5177-4514; Venkataraman,
   Srikumar/0000-0002-5367-6288; Tiwaskar, Mangesh/0000-0003-4024-0095
FU SEED Division, Department of Science and Technology,~Government of India
FX The study was financially supported by the SEED Division, Department of
   Science and Technology, Government of India.
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NR 103
TC 3
Z9 3
U1 1
U2 4
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, Maharashtra, INDIA
SN 0976-7800
EI 0976-7819
J9 J MID-LIFE HEALTH
JI J. Mid-Life Health
PD JAN-MAR
PY 2022
VL 13
IS 1
BP 34
EP +
DI 10.4103/jmh.jmh_7_22
PG 17
WC Obstetrics & Gynecology
WE Emerging Sources Citation Index (ESCI)
SC Obstetrics & Gynecology
GA 1G5SO
UT WOS:000795908200009
PM 35707299
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Moravejolahkami, AR
   Paknahad, Z
   Chitsaz, A
AF Moravejolahkami, Amir Reza
   Paknahad, Zamzam
   Chitsaz, Ahmad
TI Association of dietary patterns with systemic inflammation, quality of
   life, disease severity, relapse rate, severity of fatigue and
   anthropometric measurements in MS patients
SO NUTRITIONAL NEUROSCIENCE
LA English
DT Article
DE Dietary pattern; inflammation; quality of life; fatigue; relapse;
   multiple sclerosis
ID C-REACTIVE PROTEIN; MULTIPLE-SCLEROSIS; NUTRITIONAL INTERVENTION;
   METABOLIC SYNDROME; POSTURAL CONTROL; PEOPLE; DISABILITY; RISK; FRUIT;
   RELIABILITY
AB Background: Multiple sclerosis (MS) is associated with changes in quality of life, disability, fatigue and anthropometric measurements. The important relationship of dietary patterns with such clinical manifestations was not completely investigated.
   Aims: The goal of this study was to define the dietary patterns and their association with systemic inflammation, Health-Related Quality Of Life, disease severity, Relapse Rate, severity of fatigue and anthropometric measurements in MS subjects.
   Methods: This cross-sectional study was conducted in 261 MS patients (mean age 38.98.3). Dietary patterns were explored by a Food Frequency Questionnaire. Serum hs-CRP, Multiple Sclerosis Quality Of Life-54 item questionnaire, Extended Disability Status Scale, Fatigue Severity Scale and Visual Analog Fatigue Scale, Relapse Rate, Height, Weight and Deurenberg Equation were also used as tools. Data were analyzed by SPSS24, and using ANOVA, Tukey, Chi-square and ANCOVA tests.
   Results: Fruits, Vegetables, Low fat dairy-based pattern and Mediterranean-Like pattern were associated with lower serum hs-CRP (F=6.037, P-adjusted<0.01), higher Physical and Mental Health Composite Scores (P-adjusted<0.001), lower attacks (F=4.475, P-adjusted<0.05), lower acute and chronic fatigue (F=5.353 and F=7.011, respectively, P-adjusted<0.01), lower BMI (F=7.528, P-adjusted<0.01) and Percent Body Fat (F=6.135, P-adjusted<0.01); but no difference was observed about EDSS across the patterns.
   Conclusions: Adherence to healthy dietary patterns may reduce systemic inflammation, severity of fatigue, MS attacks, improved quality of life and balance weight especially body fat in MS patients.
C1 [Moravejolahkami, Amir Reza] Isfahan Univ Med Sci, Sch Nutr & Food Sci, Esfahan, Iran.
   [Paknahad, Zamzam] Isfahan Univ Med Sci, Sch Nutr & Food Sci, Dept Clin Nutr, POB 81745, Esfahan, Iran.
   [Chitsaz, Ahmad] Isfahan Univ Med Sci Isfahan, Dept Neurol, Esfahan, Iran.
C3 Isfahan University of Medical Sciences; Isfahan University of Medical
   Sciences; Isfahan University of Medical Sciences
RP Paknahad, Z (corresponding author), Isfahan Univ Med Sci, Sch Nutr & Food Sci, Dept Clin Nutr, POB 81745, Esfahan, Iran.
EM paknahad@hlth.mui.ac.ir
RI Chitsaz, Ahmad/D-9570-2018; paknahad, zamzam/E-6191-2012;
   Moravejolahkami, Amir Reza/AAY-7673-2021
OI Moravejolahkami, Amir Reza/0000-0001-9707-0352; paknahad,
   zamzam/0000-0002-1864-2576
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NR 77
TC 40
Z9 41
U1 0
U2 12
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1028-415X
EI 1476-8305
J9 NUTR NEUROSCI
JI Nutr. Neurosci.
PD DEC 1
PY 2020
VL 23
IS 12
BP 920
EP 930
DI 10.1080/1028415X.2019.1580831
PG 11
WC Neurosciences; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Nutrition & Dietetics
GA ZW2QZ
UT WOS:000771063800001
PM 30896320
DA 2025-06-11
ER

PT J
AU O'Donoghue, B
   Mifsud, NG
   Tindall, RM
   Foote, L
   Hartmann, JA
   Obst, K
   Simmons, MB
   McGorry, PD
   Killackey, E
AF O'Donoghue, Brian
   Mifsud, Nathan G.
   Tindall, Rachel M.
   Foote, Lauren
   Hartmann, Jessica A.
   Obst, Kate
   Simmons, Magenta B.
   McGorry, Patrick D.
   Killackey, Eoin
TI Physical health assistance in early recovery of psychosis: Study
   protocol for a randomized controlled trial
SO EARLY INTERVENTION IN PSYCHIATRY
LA English
DT Article
DE adolescent; mental health; metabolic syndrome; psychotic disorders;
   weight gain
ID SHORT-SLEEP DURATION; 1ST-EPISODE PSYCHOSIS; WEIGHT-GAIN; SCHIZOPHRENIA;
   DISORDERS; INTERVENTIONS; METAANALYSIS; MORTALITY; INDEX
AB Aim Young people with psychotic disorders have poorer physical health compared to their healthy peers, a state compounded by the metabolic side-effects of antipsychotic medications. To address this, Orygen Youth Health has introduced physical health services including exercise physiologists and dieticians. These services are typically coordinated by the case manager and doctor. It is not yet known whether a treating team member dedicated to physical health will improve engagement, adherence and outcomes with these services. Hence, the protocol is presented here for a trial to evaluate the effect of including a physical health nurse in the care of young people with first-episode psychosis. Methods This will be a single-blind randomized controlled trial that includes 15- to 24-year-olds with first-episode psychosis who have just commenced (within 30 days) antipsychotic medication. The primary outcome will be the event of clinically significant weight gain (>= 7% body weight). Participants will be assigned either a physical health nurse in their treating team (in addition to the case manager and doctor) for a 12-week period, or treatment as usual (case manager and doctor). Research assessments will be conducted at baseline, 12 and 26 weeks. Activity trackers worn by participants for the study's duration will measure sleep and physical activity. Conclusion The present study will determine whether a physical health nurse will facilitate participants in attending and engaging in physical health interventions and whether this will be associated with physical health improvements or the prevention of worsening physical health.
C1 [O'Donoghue, Brian; Mifsud, Nathan G.; Tindall, Rachel M.; Hartmann, Jessica A.; Obst, Kate; Simmons, Magenta B.; McGorry, Patrick D.; Killackey, Eoin] Orygen, Natl Ctr Excellence Youth Mental Hlth, Parkville, Vic, Australia.
   [O'Donoghue, Brian; Mifsud, Nathan G.; Tindall, Rachel M.; Hartmann, Jessica A.; Simmons, Magenta B.; McGorry, Patrick D.; Killackey, Eoin] Univ Melbourne, Ctr Youth Mental Hlth, Melbourne, Vic, Australia.
   [O'Donoghue, Brian; Foote, Lauren] Orygen Youth Hlth, Mental Hlth Serv, Parkville, Vic, Australia.
C3 Orygen, The National Centre of Excellence in Youth Mental Health;
   Orygen, The National Centre of Excellence in Youth Mental Health;
   University of Melbourne; Orygen, The National Centre of Excellence in
   Youth Mental Health
RP O'Donoghue, B (corresponding author), Univ Melbourne, Ctr Youth Mental Hlth, Natl Ctr Excellence Youth Mental Hlth, Orygen, Locked Bag 10, Parkville, Vic 3052, Australia.
EM brian.odonoghue@orygen.org.au
RI Mete, Rachel/KBC-6226-2024; Simmons, Magenta/AER-9616-2022; McGorry,
   Patrick/O-4115-2019; Hartmann, Jessica/N-7771-2013; ODonoghue,
   Brian/E-6130-2015; Tindall, Rachel/P-7790-2014; Simmons,
   Magenta/C-8045-2015
OI Hartmann, Jessica/0000-0001-7662-6155; ODonoghue,
   Brian/0000-0001-6240-6952; Tindall, Rachel/0000-0002-0898-4302; Simmons,
   Magenta/0000-0002-8544-8917; McGorry, Patrick/0000-0002-3789-6168
FU National Health and Medical Research Council of Australia [1142045]
   Funding Source: NHMRC; National Health and Medical Research Council
   [1142045] Funding Source: Medline; University of Melbourne [Early Career
   Researcher Grant] Funding Source: Medline; Morris Family Foundation
   Funding Source: Medline
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NR 37
TC 6
Z9 6
U1 0
U2 21
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1751-7885
EI 1751-7893
J9 EARLY INTERV PSYCHIA
JI Early Interv. Psychiatry
PD OCT
PY 2020
VL 14
IS 5
BP 587
EP 593
DI 10.1111/eip.12884
PG 7
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA NI9RA
UT WOS:000565681800009
PM 31643142
OA Green Published
DA 2025-06-11
ER

PT J
AU Fleischhaker, C
   Heiser, P
   Hennighausen, K
   Herpertz-Dahlmann, B
   Holtkamp, K
   Mehler-Wex, C
   Rauh, R
   Remschmidt, H
   Schulz, E
   Warnke, A
AF Fleischhaker, Christian
   Heiser, Philip
   Hennighausen, Klaus
   Herpertz-Dahlmann, Beate
   Holtkamp, Kristian
   Mehler-Wex, Claudia
   Rauh, Reinhold
   Remschmidt, Helmut
   Schulz, Eberhard
   Warnke, Andreas
TI Clinical drug monitoring in child and adolescent psychiatry: Side
   effects of atypical neuroleptics
SO JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY
LA English
DT Article; Proceedings Paper
CT 16th World Congress of the
   International-Association-for-Child-and-Adolescent-Psychiatry-and-Allied
   -Professions (IACAPAP)
CY AUG 22-26, 2004
CL Berlin, GERMANY
SP Int Assoc Child Adolescent Psychiat & Allied Profess
ID OPEN-LABEL TRIAL; ONSET SCHIZOPHRENIA; WEIGHT-GAIN; DOUBLE-BLIND;
   RISPERIDONE; OLANZAPINE; CLOZAPINE; HALOPERIDOL; SAFETY; MEDICATIONS
AB Objective: The aim of this study was to improve and evaluate the practibility of a method for the assessment of drug-associated side effects, and we implemented a clinical drug monitoring for atypical neuroleptics.
   Methods: Side effects of initially hospitalized patients treated with clozapine (n = 16), olanzapine (n = 16), and risperidone (n = 19) were prospectively monitored on a weekly basis for the first 3 weeks. In the case of stable medication, measurements of all variables were made every 4 weeks or upon discharge. We used the Dosage Record Treatment Emergent Symptom Scale (DOTES) in a supplemented version to measure the presence and severity of side effects.
   Results: Drowsiness and decreased motor activity were common, especially in the first 2 weeks. Orthostatic hypotension, increased salivation, constipation, and nasal congestion were seen in more than 30% to 60% of patients treated with clozapine and were less common in adolescents treated with olanzapine and risperidone. Rigidity, tremor, and dystonia were seen in 5% to 15% of patients treated with risperidone and olanzapine. The average weight gain after 6 weeks of treatment with the atypical neuroleptics was significantly higher for the olanzapine group (4.6 +/- 1.9 kg) than for the risperidone (2.8 +/- 1.3 kg) and clozapine (2.5 +/- 2.9 kg) groups.
   Conclusions: The authors' supplemented DOTES version is generally applicable to clinical use in mental health centers. The differences among the side effects of these three agents may affect compliance with medication and medical risks of metabolic syndrome, diabetes, and cardiovascular disease. More research on the short- and long-term safety of psychotropic drugs in children and adolescents, using standardized methods, should be considered.
C1 Univ Freiburg, Dept Child & Adolescent Psychiat & Psychotherapy, D-79104 Freiburg, Germany.
   Univ Marburg, Clin & Policlin Psychiat & Psychotherapy Child &, Marburg, Germany.
   Univ Aachen, Rhein Westfal TH Aachen, Clin Child & Adolescent Psychiat, Univ Clin, D-5100 Aachen, Germany.
   Univ Wurzburg, Clin & Polyclin Child & Adolescent Psychiat, Wurzburg, Germany.
C3 University of Freiburg; Philipps University Marburg; RWTH Aachen
   University; RWTH Aachen University Hospital; University of Wurzburg
RP Fleischhaker, C (corresponding author), Univ Freiburg, Dept Child & Adolescent Psychiat & Psychotherapy, Hauptstr 8, D-79104 Freiburg, Germany.
EM fleischhaker@psyallg.ukl.uni-freiburg.de
RI Rauh, Reinhold/S-6361-2019; Konrad, Kerstin/H-7747-2013
OI Rauh, Reinhold/0000-0003-3053-1163
CR Allison DB, 1999, AM J PSYCHIAT, V156, P1686
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NR 32
TC 44
Z9 48
U1 0
U2 9
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1044-5463
EI 1557-8992
J9 J CHILD ADOL PSYCHOP
JI J. Child Adolesc. Psychopharmacol.
PD JUN
PY 2006
VL 16
IS 3
BP 308
EP 316
DI 10.1089/cap.2006.16.308
PG 9
WC Pediatrics; Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI); Conference Proceedings Citation Index - Science (CPCI-S)
SC Pediatrics; Pharmacology & Pharmacy; Psychiatry
GA 055OC
UT WOS:000238459000009
PM 16768638
DA 2025-06-11
ER

PT J
AU Yu, ZM
   Parker, L
   Dummer, TJB
AF Yu, Zhijie M.
   Parker, Louise
   Dummer, Trevor J. B.
TI Depressive symptoms, diet quality, physical activity, and body
   composition among populations in Nova Scotia, Canada: Report from the
   Atlantic Partnership for Tomorrow's Health
SO PREVENTIVE MEDICINE
LA English
DT Article
DE Depressive symptom; Obesity; Diet quality; Physical activity
ID UNHEALTHY BEHAVIORS; METABOLIC SYNDROME; MAJOR DEPRESSION; EATING INDEX;
   MASS INDEX; ASSOCIATION; DISEASE; RISK; PREVENTION; OBESITY
AB Objective. To investigate the association between depressive symptoms and diet quality, physical activity, and body composition among Nova Scotians.
   Methods. 4511 men and women aged 35-69 years were recruited to the Atlantic Partnership for Tomorrow's Health study from 2009 through 2010 in Nova Scotia, Canada. Depressive symptoms were assessed by using the Patient Health Questionnaire. Anthropometric indexes and body composition were measured. Current antidepressant use, habitual diet intake, physical activity, and potential confounders were collected through questionnaires.
   Results. In multivariable regression analyses, depressive symptoms were positively associated with all obese indexes after controlling for potential confounders (all P for trend <0.001). Compared with non-depressed individuals, those with mild and major depression had significantly increased odds ratios (ORs) for both obesity and abdominal obesity (OR 1.84; 95% confidence interval [CI], (1.50, 2.25) and 1.56 (95% CI, 1.30, 1.87) for obesity and 1.46 (95% CI, 1.20, 1.77) and 1.88 (95% CI, 1.58, 2.24) for abdominal obesity, respectively). Depressed individuals were less likely to have a high quality diet or engage in high levels of physical activity compared with their non-depressed counterparts.
   Conclusions. Depressive symptoms are associated with higher levels of obesity, poor diet, and physical inactivity among Nova Scotians in Canada. (C) 2013 Elsevier Inc. All rights reserved.
C1 Dalhousie Univ, Populat Canc Res Program, Halifax, NS, Canada.
   Dalhousie Univ, Dept Pediat, Halifax, NS, Canada.
C3 Dalhousie University; Dalhousie University
RP Dummer, TJB (corresponding author), 1494 Carlton St,Box 15000, Halifax, NS B3H 4R2, Canada.
EM trevor.dummer@dal.ca
OI PARKER, LOUISE/0000-0002-5188-8113
FU Canadian Partnership against Cancer; Health Canada
FX Production of this study has been made possible through the financial
   support from the Canadian Partnership against Cancer and Health Canada.
   We acknowledge the support of all participants in the Atlantic PATH
   Project The study funder had no involvement in the study design; in the
   collection, analysis and interpretation of data; in the writing of the
   report; and in the decision to submit the article for publication.
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NR 53
TC 48
Z9 51
U1 0
U2 18
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0091-7435
EI 1096-0260
J9 PREV MED
JI Prev. Med.
PD APR
PY 2014
VL 61
BP 106
EP 113
DI 10.1016/j.ypmed.2013.12.022
PG 8
WC Public, Environmental & Occupational Health; Medicine, General &
   Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; General & Internal Medicine
GA AD8WB
UT WOS:000333545300017
PM 24380795
DA 2025-06-11
ER

PT J
AU Strassnig, M
   Cornacchio, D
   Harvey, PD
   Kotov, R
   Fochtmann, L
   Bromet, EJ
AF Strassnig, M.
   Cornacchio, D.
   Harvey, P. D.
   Kotov, R.
   Fochtmann, L.
   Bromet, E. J.
TI Health status and mobility limitations are associated with residential
   and employment status in schizophrenia and bipolar disorder
SO JOURNAL OF PSYCHIATRIC RESEARCH
LA English
DT Article
ID SEVERE MENTAL-ILLNESS; BODY-MASS INDEX; METABOLIC SYNDROME;
   FUNCTIONAL-CAPACITY; DISABILITY; COGNITION; OBESITY; EPIDEMIOLOGY;
   HYPERTENSION; INDIVIDUALS
AB Introduction: Schizophrenia (SCZ) and bipolar disorder (BP) are linked to multiple impairments in everyday functioning which share cognitive and symptom risk factors. Other risk factors for critical aspects of every day functioning (e.g., gainful employment; residential independence) such as physical health have not been evaluated, despite poor health in SCZ and BP.
   Methods: We analyzed 20-year follow-up data from the Suffolk County Mental Health Project cohort of consecutive first admissions with a psychotic disorder to 12 psychiatric facilities in Suffolk County, NY, between September 1989 and December 1995. Both 20-year symptom, health, and cognition data, and the 20-year course of weight gain were included as predictors of employment and residence status.
   Results: The analysis sample consisted of 122 participants with SCZ ad BP, with SCZ participants less likely to work or live independently. Correlational analyses showed symptoms and cognition predicted vocational outcomes in both samples. The effect of diagnosis was significant for both gainful employment and independence in residence. After consideration of diagnosis, mobility and negative symptoms predicted gainful employment in both samples, but there were no additional predictors of residential independence. Prospective analysis of BMI found that baseline BMI, but not changes during the 20-year follow up, predicted labor force participation.
   Discussion: Health status limitations were associated with residential and, particularly, employment status independent from other, previously established predictors of everyday outcomes, including cognition and symptoms. The importance of health status limitations for predicting outcome was confirmed in both SCZ and BP, with schizophrenia representing the more impaired group. (C) 2017 Elsevier Ltd. All rights reserved.
C1 [Strassnig, M.] Florida Atlantic Univ, Dept Integrated Med Sci, Charles E Schmidt Coll Med, 777 Glades Rd, Boca Raton, FL 33431 USA.
   [Cornacchio, D.] Florida Int Univ, Sch Integrated Sci & Humanity, Miami, FL 33199 USA.
   [Harvey, P. D.] Univ Miami, Miller Sch Med, Dept Psychiat, Miami, FL 33136 USA.
   [Kotov, R.; Fochtmann, L.; Bromet, E. J.] SUNY Stony Brook, Dept Psychiat, Stony Brook, NY 11794 USA.
C3 State University System of Florida; Florida Atlantic University; State
   University System of Florida; Florida International University;
   University of Miami; State University of New York (SUNY) System; Stony
   Brook University
RP Strassnig, M (corresponding author), Florida Atlantic Univ, Dept Integrated Med Sci, Charles E Schmidt Coll Med, 777 Glades Rd, Boca Raton, FL 33431 USA.
EM mstrassnig@health.fau.edu
RI Kotov, Roman/KZV-1103-2024; Harvey, Philip/D-2455-2012
OI Harvey, Philip/0000-0002-9501-9366; Fochtmann, Laura/0000-0001-5080-921X
FU Allergan; Boehringer Ingelheim; Lundbeck Pharma; Minerva Pharma; Otsuka
   Digital Health; Sanofi Pharma; Sunovion Pharma; Takeda Pharma; Takeda
   [2014 100914]; Stanley Medical Research Foundation [151]
FX Dr. Harvey has received consulting fees or travel reimbursements from
   Allergan, Boehringer Ingelheim, Lundbeck Pharma, Minerva Pharma, Otsuka
   Digital Health, Sanofi Pharma, Sunovion Pharma, and Takeda Pharma during
   the past year. He has a research grant from Takeda 2014 100914 and from
   the Stanley Medical Research Foundation Grant 151.
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NR 47
TC 26
Z9 26
U1 0
U2 8
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-3956
EI 1879-1379
J9 J PSYCHIATR RES
JI J. Psychiatr. Res.
PD NOV
PY 2017
VL 94
BP 180
EP 185
DI 10.1016/j.jpsychires.2017.07.011
PG 6
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA FJ7TD
UT WOS:000412960900023
PM 28743064
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Vasiliu, O
AF Vasiliu, Octavian
TI Current evidence and future perspectives in the exploration of
   sleep-related eating disorder-a systematic literature review
SO FRONTIERS IN PSYCHIATRY
LA English
DT Article
DE sleep-related eating disorder; night eating syndrome; parasomnia;
   disorders of arousal; topiramate; clonazepam; pramipexole; zolpidem
ID RESTLESS LEGS SYNDROME; PSYCHIATRIC OUTPATIENTS; RETROSPECTIVE ANALYSIS;
   COMPLEX BEHAVIORS; FOOD-INTAKE; PARASOMNIAS; SLEEPWALKING; ZOLPIDEM;
   THERAPY; TOPIRAMATE
AB Sleep-related eating disorder (SRED) is a non-REM parasomnia with potentially significant negative effects on general health (dangerous activities during night eating episodes, obesity, or metabolic syndrome, for example). Although the history of SRED encompasses more than six decades, public awareness and even the awareness of the mental health specialists of this disorder is very limited, a phenomenon that hinders the development of research in this field. Therefore, a systematic review based on PRISMA 2020 guidelines explored the available evidence for SRED found in four electronic databases (PubMed, Cochrane Collaboration, Google Scholar, and Clarivate/Web of Science). A number of 94 primary and secondary reports were retrieved, investigating aspects regarding the risk factors, epidemiology, clinical data and differential diagnosis, epidemiology, structured evaluation, and treatment of SRED. Based on the results of these reports, Z-drugs, but also certain benzodiazepines, antidepressants, antipsychotics, and psychostimulants may trigger the onset of SRED. Psychiatric and neurologic disorders have also been associated with SRED, either as risk factors or comorbid conditions. Cerebral glucose metabolism dysfunctions, neurotransmitter dysfunctions, and genetic factors have been invoked as pathogenetic contributors. Structured assessment of SRED is possible, but there is a dearth of instruments dedicated to this purpose. Data on the prevalence and treatment of SRED exist, but good-quality epidemiological studies and clinical trials are still missing. In conclusion, future research is expected to address the shortcomings of SRED exploration by creating the conditions for better quality and larger group clinical research. The need for such investigation is granted by the importance of this pathology and its negative functional consequences.
C1 [Vasiliu, Octavian] Dr Carol Davila Univ Emergency Cent Mil Hosp, Dept Psychiat, Bucharest, Romania.
RP Vasiliu, O (corresponding author), Dr Carol Davila Univ Emergency Cent Mil Hosp, Dept Psychiat, Bucharest, Romania.
EM octavvasiliu@yahoo.com
RI Vasiliu, Octavian/AAL-2136-2020
OI Vasiliu, Octavian/0000-0001-6345-3478
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NR 161
TC 2
Z9 2
U1 0
U2 1
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-0640
J9 FRONT PSYCHIATRY
JI Front. Psychiatry
PD MAY 30
PY 2024
VL 15
AR 1393337
DI 10.3389/fpsyt.2024.1393337
PG 25
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA UL5J7
UT WOS:001248224500001
PM 38873533
OA Green Submitted, gold, Green Published
DA 2025-06-11
ER

PT J
AU Reardon, B
   Toles, M
   Cuddeback, G
   Travers, D
AF Reardon, Brandy
   Toles, Mark
   Cuddeback, Gary
   Travers, Debbie
TI Perceptions of ACT Team Members on the Implementation of Physical Health
   Services: A Qualitative Study
SO JOURNAL OF THE AMERICAN PSYCHIATRIC NURSES ASSOCIATION
LA English
DT Article
DE severe mental illness; ACT teams; physical health care; implementation
ID ASSERTIVE COMMUNITY TREATMENT; SEVERE MENTAL-ILLNESS; CRITICAL
   INGREDIENTS; METABOLIC SYNDROME; PRIMARY-CARE; SCHIZOPHRENIA; PEOPLE;
   RISK; PREVALENCE; MORTALITY
AB Background: Adults with severe mental illnesses have mortality rates 2.5 to 3 times higher than the general population, largely due to medical illnesses. Those with the most profound mental illnesses are served by assertive community treatment (ACT) teams that provide intensive mental health care; however, there are no clearly established models to integrate physical health treatment into ACT and this is a critical gap in the literature. Aims: To describe perceptions of ACT team members regarding services provided for their clients to treat physical health, how those services can be improved, and what implementation strategies would likely be needed to promote uptake and sustainability of those services on ACT teams. Method: Qualitative interviews were conducted via Zoom using a semistructured interview guide with 19 employees from three ACT teams in a southeastern state. Interview transcripts were analyzed, using manifest content analysis, a form of qualitative analysis, to identify key themes in the interview transcripts. Results: ACT team members described limited physical health services for their clients. They reported (1) system-level barriers to improving physical health care, such as inadequate tools and training; and (2) patient-level barriers, such as limited awareness of physical care needs. ACT team members reported the need for additional medical staff and strengthened relationships with primary care providers. They also recommended changes in policy, education, and quality monitoring to implement new physical health care services. Conclusions: Findings suggest intervention components and implementation strategies for improving physical health care of ACT consumers.
C1 [Reardon, Brandy; Toles, Mark; Cuddeback, Gary] Univ N Carolina, Carrington Hall,S Columbia St, Chapel Hill, NC 27599 USA.
   [Travers, Debbie] Duke Univ, Chapel Hill, NC USA.
C3 University of North Carolina; University of North Carolina Chapel Hill;
   Duke University
RP Reardon, B (corresponding author), Univ N Carolina, Carrington Hall,S Columbia St, Chapel Hill, NC 27599 USA.
EM brandyjreardon@gmail.com
OI Reardon, Brandy/0000-0002-3275-4080
FU National Institute of Nursing Research of the National Institutes of
   Health [T32NR007091]; Samuel B. Kellett Long Future Nursing Faculty
   Scholarship
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: Research
   reported in this publication was supported by the National Institute of
   Nursing Research of the National Institutes of Health under Award Number
   T32NR007091. The content is solely the responsibility of the authors and
   does not necessarily represent the official views of the National
   Institutes of Health. Research reported in this publication was also
   supported in part by a Samuel B. Kellett Long Future Nursing Faculty
   Scholarship.
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NR 36
TC 0
Z9 0
U1 0
U2 1
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1078-3903
EI 1532-5725
J9 J AM PSYCHIAT NURSES
JI J. Am. Psych. Nurses Assoc.
PD JAN
PY 2024
VL 30
IS 1
BP 108
EP 120
AR 10783903221079800
DI 10.1177/10783903221079800
EA FEB 2022
PG 13
WC Nursing; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Psychiatry
GA FM4L5
UT WOS:000763653300001
PM 35220783
DA 2025-06-11
ER

PT J
AU Vancampfort, D
   Guelinckx, H
   Probst, M
   Stubbs, B
   Rosenbaum, S
   Ward, PB
   De Hert, M
AF Vancampfort, Davy
   Guelinckx, Hannes
   Probst, Michel
   Stubbs, Brendon
   Rosenbaum, Simon
   Ward, Philip B.
   De Hert, Marc
TI Health-related quality of life and aerobic fitness in people with
   schizophrenia
SO INTERNATIONAL JOURNAL OF MENTAL HEALTH NURSING
LA English
DT Article
DE aerobic fitness; psychosis; quality of life; schizophrenia
ID PHYSICAL-ACTIVITY; SEDENTARY BEHAVIOR; FUNCTIONAL-CAPACITY; METABOLIC
   SYNDROME; EXERCISE; SYMPTOMS; RISK; INDIVIDUALS; ASSOCIATION;
   RELIABILITY
AB The purpose of this cross-sectional study was to investigate whether aerobic fitness contributes to the health-related quality of life (HRQoL) in people with schizophrenia, while adjusting for other previously-established contributory factors. Thirty-four male (34.1 +/- 12.0 years) and 13 female (34.3 +/- 9.2 years) participants performed a submaximal Astrand-Rhyming cycle ergometer test and completed the 36-item Short-Form Health Survey, the International Physical Activity Questionnaire, and the Psychosis Evaluation tool for Common Use by Caregivers. After controlling for age and sex, illness duration (12.4 +/- 11.2 years, r(2)=0.38, P<0.001), fewer positive (9.3 +/- 4.3, r(2)=0.30, P=0.006) and cognitive (8.4 +/- 3.8, r(2)=0.28, P=0.011) symptoms, and higher aerobic fitness (34.5 +/- 8.7ml O(2)min(-1)kg(-1), r(2)=0.36, P=0.001) were found to be independent significant predictors of physical HRQoL (mean score 66.6 +/- 18.5). However, when all variables were included in the same regression model, only illness duration (P=0.004) and positive symptoms (P=0.045) remained significant predictors, while there was a trend (P<0.10) for age and aerobic fitness. The final model explained 54% of the variability in physical HRQoL. No significant correlates for mental HRQoL (54.9 +/- 18.5) were found. People with schizophrenia might improve their physical HRQoL by improving their aerobic fitness. Mental health nurses should assist in facilitating improvements in aerobic fitness through facilitating physical activity participation in patients with schizophrenia.
C1 [Vancampfort, Davy; Guelinckx, Hannes; Probst, Michel; De Hert, Marc] KU Leuven Univ Leuven, Dept Rehabil Sci, B-3001 Louvain, Belgium.
   [Vancampfort, Davy; Probst, Michel] KU Leuven Univ Leuven, Dept Neurosci, Kortenberg, Belgium.
   [Stubbs, Brendon; De Hert, Marc] Univ Greenwich, Sch Hlth & Social Care, London SE18 6PF, England.
   [Rosenbaum, Simon; Ward, Philip B.] Univ New S Wales, Sch Psychiat, Schizophrenia Res Unit, Sydney, NSW 2052, Australia.
C3 KU Leuven; KU Leuven; University of Greenwich; University of New South
   Wales Sydney
RP Vancampfort, D (corresponding author), KU Leuven Univ Leuven, Dept Rehabil Sci, Tervuursevest 101, B-3001 Louvain, Belgium.
EM Davy.Vancampfort@uc-kortenberg.be
RI De Hert, Marc/AAH-6090-2021; Rosenbaum, Simon/Y-3241-2019; Vancampfort,
   Davy/AAD-1987-2019; Stubbs, Brendon/X-1904-2018; Probst,
   Michel/ABE-6137-2020; Ward, Philip/JCE-6293-2023; Stubbs,
   Brendon/C-5696-2015
OI Ward, Philip/0000-0002-5779-7722; De Hert, Marc/0000-0003-4255-5920;
   Stubbs, Brendon/0000-0001-7387-3791; Rosenbaum,
   Simon/0000-0002-8984-4941
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NR 45
TC 34
Z9 36
U1 0
U2 24
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1445-8330
EI 1447-0349
J9 INT J MENT HEALTH NU
JI Int. J. Ment. Health Nurs.
PD OCT
PY 2015
VL 24
IS 5
BP 394
EP 402
DI 10.1111/inm.12145
PG 9
WC Nursing; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Psychiatry
GA CQ6QN
UT WOS:000360729100003
PM 26215311
DA 2025-06-11
ER

PT J
AU Schröder, H
   Vila, J
   Marrugat, J
   Covas, MI
AF Schroeder, Helmut
   Vila, Joan
   Marrugat, Jaume
   Covas, Maria-Isabel
TI Low energy density diets are associated with favorable nutrient intake
   profile and adequacy in free-living elderly men and women
SO JOURNAL OF NUTRITION
LA English
DT Article
ID PHYSICAL-ACTIVITY QUESTIONNAIRE; BODY-MASS-INDEX; MEDITERRANEAN DIET;
   OLDER-ADULTS; SPANISH POPULATION; METABOLIC SYNDROME; NERVOUS-SYSTEM;
   OBESE WOMEN; FAT-CONTENT; FOOD
AB Nutrient adequacy in the diet is of paramount importance to physical and mental health. The aim of this study was to characterize the dietary pattern associated with a low energy density diet and determine its nutrient adequacy in elderly men and women. The subjects were men (n = 1150) and women (n = 1094) >65y, examined in 2 population-based cross-sectional surveys (2000 and 2005) in northeast Spain (Girona). Dietary data were recorded using a 165-item FFQ. Reduced rank regression (RRR) analysis was used to identify an energy density-associated dietary pattern. A nutrient adequacy score (NAS) and Mediterranean diet score (MDS) were computed to estimate the association of diet adequacy with energy density. The RRR-derived factor (dietary pattern) predicted 75.4% of the variance in energy density of the diet. Vegetables, fruits, legumes, cooked potatoes, and low-fat milk and yogurt were key to the low energy density of the diet. Higher proportions of men and women consuming low energy density diets met dietary recommendations for total fat, saturated fat, cholesterol, total fiber, vitamin C, vitamin E, thiamin, riboflavin, vitamin B-6, folate, calcium, and magnesium than their peers on high energy density diets. Multivariate linear regression analysis revealed an inverse association (P < 0.001) of the NAS and MDS with energy density and energy density-related patterns. A low energy density diet has a higher capacity to prevent nutrient deficiency, despite lower energy content, than a high energy density diet in the elderly population studied.
C1 [Schroeder, Helmut; Covas, Maria-Isabel] IMIM Hosp del Mar, Cardiovasc Risk & Nutr Res Grp CARIN ULEC, Barcelona 08003, Spain.
   [Vila, Joan; Marrugat, Jaume] IMIM Hosp del Mar, Cardiovasc Epidemiol & Genet Res Grp EGEC ULEC, Barcelona 08003, Spain.
   [Marrugat, Jaume] Program Res Inflammatory & Cardiovasc Disorders R, Barcelona 08003, Spain.
C3 Hospital del Mar Research Institute; Hospital del Mar; Hospital del Mar
   Research Institute; Hospital del Mar
RP Schröder, H (corresponding author), IMIM Hosp del Mar, Cardiovasc Risk & Nutr Res Grp CARIN ULEC, Biomed Res Pk, Barcelona 08003, Spain.
EM hschroeder@imim.es
RI ; Schroder, Helmut/G-2586-2015
OI Marrugat, Jaume/0000-0003-3320-554X; Schroder,
   Helmut/0000-0003-2231-5081; Vila-Domenech, Joan
   Salvador/0000-0002-0413-9291
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NR 42
TC 46
Z9 49
U1 0
U2 10
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0022-3166
EI 1541-6100
J9 J NUTR
JI J. Nutr.
PD AUG
PY 2008
VL 138
IS 8
BP 1476
EP 1481
DI 10.1093/jn/138.8.1476
PG 6
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 332UG
UT WOS:000258108000013
PM 18641194
OA Bronze
DA 2025-06-11
ER

PT J
AU Leckman-Westin, E
   Kealey, E
   Gupta, N
   Chen, QX
   Gerhard, T
   Crystal, S
   Olfson, M
   Finnerty, M
AF Leckman-Westin, Emily
   Kealey, Edith
   Gupta, Nitin
   Chen, Qingxian
   Gerhard, Tobias
   Crystal, Stephen
   Olfson, Mark
   Finnerty, Molly
TI Validation of a claims-based antipsychotic polypharmacy measure
SO PHARMACOEPIDEMIOLOGY AND DRUG SAFETY
LA English
DT Article
DE antipsychotic polypharmacy; administrative data; sensitivity; positive
   predictive value; Medicaid; pharmacoepidemiology
ID MEDICAID PROGRAM; PRESCRIBING PRACTICES; METABOLIC SYNDROME;
   SCHIZOPHRENIA; TRENDS; MONOTHERAPY; PREVALENCE; STATE; STRATEGIES;
   EXPERIENCE
AB PurposeGiven the metabolic and neurologic side effects of antipsychotics and concerns about the increased risks associated with concomitant use, antipsychotic polypharmacy is a quality concern. This study assessed the operating characteristics of a Medicaid claims-based measure of antipsychotic polypharmacy. MethodsA random sample from 10 public mental health clinics and 312 patients met criteria for this study. Medical record extractors were blind to measure status. We examined the prevalence, sensitivity, specificity, and positive predictive value (PPV) in Medicaid claims, testing nine different definitions of antipsychotic polypharmacy, including >14, >60, or >90days concurrent use of 2 antipsychotic agents, each with allowable gaps of up to 0, 14, or 32days in days' supply of antipsychotic medications. ResultsAll Medicaid claims measure definitions tested had excellent specificity and PPV (>91%). Good to excellent sensitivity was dependent upon use of a 32-day gap allowance, particularly as duration of concurrent antipsychotic use increased. The proposed claims-based measure (90-day concurrent use of 2 or more antipsychotics, allowing for a 32-day gap) had excellent specificity (99.1%, 95%CI: 98.2-99.6) and PPV (90.9%, 95%CI: 83.1-95.7) with good sensitivity (79.4%, 95%CI: 70.4-86.6). The overall level of concordance between claims and medical record-based categorization of antipsychotic polypharmacy was high (96.4%, n=301/312 clients, Cohen's K=84.7, 95%CI: 75.9-93.5). Discrepant cases were reviewed, and implications are discussed. ConclusionsAdministrative claims data can be used to construct valid measures of antipsychotic polypharmacy. Copyright (c) 2014 John Wiley & Sons, Ltd.
C1 [Leckman-Westin, Emily; Kealey, Edith; Gupta, Nitin; Chen, Qingxian; Finnerty, Molly] New York State Off Mental Hlth, New York, NY 12228 USA.
   [Leckman-Westin, Emily] SUNY Albany, Sch Publ Hlth, Dept Epidemiol & Biostat, Rensselaer, NY USA.
   [Finnerty, Molly] NYU, Sch Med, Dept Child & Adolescent Psychiat, New York, NY USA.
   [Olfson, Mark] Columbia Univ, Dept Psychiat, Med Ctr, New York, NY USA.
   [Gerhard, Tobias; Crystal, Stephen] Rutgers State Univ, Inst Hlth Hlth Care Policy & Aging Res, New Brunswick, NJ 08903 USA.
C3 State University of New York (SUNY) System; University at Albany, SUNY;
   New York University; Columbia University; Rutgers University System;
   Rutgers University New Brunswick
RP Leckman-Westin, E (corresponding author), New York State Off Mental Hlth, CDPC Unit R, 75 New Scotland Ave, New York, NY 12228 USA.
EM Emily.Leckman-Westin@OMH.NY.GOV
RI Olfson, Mark/AAA-8547-2021; gupta, nitin/ABF-1788-2020
OI Finnerty, Molly/0000-0003-2035-5637; Gerhard, Tobias/0000-0002-8598-5771
FU AHRQ HHS [U19 HS021112] Funding Source: Medline; NIMH NIH HHS [P30
   MH090322] Funding Source: Medline
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NR 37
TC 16
Z9 17
U1 0
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1053-8569
EI 1099-1557
J9 PHARMACOEPIDEM DR S
JI Pharmacoepidemiol. Drug Saf.
PD JUN
PY 2014
VL 23
IS 6
BP 628
EP 635
DI 10.1002/pds.3609
PG 8
WC Public, Environmental & Occupational Health; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; Pharmacology & Pharmacy
GA AJ2YS
UT WOS:000337532000011
PM 24664793
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Koreki, A
   Nozaki, S
   Shikimoto, R
   Tsugane, S
   Mimura, M
   Sawada, N
AF Koreki, Akihiro
   Nozaki, Shoko
   Shikimoto, Ryo
   Tsugane, Shoichiro
   Mimura, Masaru
   Sawada, Norie
TI A longitudinal cohort study demonstrating the beneficial effect of
   moderate consumption of green tea and coffee on the prevention of
   dementia: The JPHC Saku Mental Health Study
SO JOURNAL OF ALZHEIMERS DISEASE
LA English
DT Article
DE Alzheimer's disease; coffee; dementia; green tea
ID MILD COGNITIVE IMPAIRMENT; ALZHEIMERS-DISEASE; METABOLIC SYNDROME;
   LATE-LIFE; RISK; JAPANESE
AB Background While the preventive effects of green tea and coffee on cognitive decline have been demonstrated, their long-term effects on cognition remain unclear.Objective This study aims to investigate the effect of green tea and coffee consumption in middle age on the prevention of dementia.Methods This population-based cohort study included 1155 participants (aged 44-66 in 1995). Participants' consumption of green tea and coffee was assessed using questionnaires in 1995 and 2000. Their cognitive levels were neuropsychologically evaluated in 2025-2015. Logistic regression analyses were conducted with significant cognitive decline (defined as multi-domain cognitive decline and more severe conditions) as the dependent variable. Stratified analyses were also conducted by sex and age.Results Individuals who consumed 2-3 cups of green tea daily had a significantly reduced risk of cognitive decline (OR = 0.56, 95%CI: 0.35-0.91) after adjusting potential confounders. However, this effect was not significant with consumption of 4 or more cups. This protective effect was particularly observed in males (OR = 0.38, 95%CI: 0.19-0.76). A significant risk reduction was also observed in individuals consuming one or more cups of coffee daily (OR = 0.54, 95%CI: 0.34-0.84) in the older subjects (median age [53 years old] and older in 1995) in the same fully adjusted model, but not in the entire sample.Conclusions Our findings suggest that moderate green tea consumption in midlife may have a beneficial effect on preventing dementia, particularly in males. The effects of coffee consumption may be more advantageous for older individuals.
C1 [Koreki, Akihiro; Nozaki, Shoko; Shikimoto, Ryo; Mimura, Masaru] Keio Univ, Sch Med, Dept Neuropsychiat, Tokyo, Japan.
   [Koreki, Akihiro; Nozaki, Shoko] NHO Shimofusa Psychiat Med Ctr, Dept Psychiat, 578 Hetacho Midori Ku, Chiba 2660007, Japan.
   [Tsugane, Shoichiro; Sawada, Norie] Natl Canc Ctr Japan, Natl Canc Ctr Inst Canc Control, Div Cohort Res, Tokyo, Japan.
   [Tsugane, Shoichiro] Int Univ Hlth & Welf, Grad Sch Publ Hlth, Tokyo, Japan.
C3 Keio University; National Cancer Center - Japan; International
   University of Health & Welfare
RP Nozaki, S (corresponding author), NHO Shimofusa Psychiat Med Ctr, Dept Psychiat, 578 Hetacho Midori Ku, Chiba 2660007, Japan.; Sawada, N (corresponding author), Natl Canc Ctr Inst Canc Control, Div Cohort Res, 5-1-1 Tsukiji,Chuo Ku, Tokyo 1040045, Japan.
EM shoko@jb3.so-net.ne.jp; nsawada@ncc.go.jp
RI Tsugane, Shoichiro/A-2424-2015; Shikimoto, Ryo/AFD-1967-2022; Koreki,
   Akihiro/JPP-4976-2023
FU National Cancer Center Research and Development Fund
FX We appreciate all the personnel involved in this cohort study. In the
   initial preparation of this manuscript, ChatGPT-4 was used solely for
   grammar checks and to enhance the readability of the paper.
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NR 47
TC 1
Z9 1
U1 2
U2 2
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1387-2877
EI 1875-8908
J9 J ALZHEIMERS DIS
JI J. Alzheimers Dis.
PD JAN
PY 2025
VL 103
IS 2
BP 519
EP 527
DI 10.1177/13872877241303709
EA JAN 2025
PG 9
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA W0D9K
UT WOS:001415400300025
PM 39772974
DA 2025-06-11
ER

PT J
AU Prather, H
   Leupold, O
   Suter, C
   Mehta, N
   Griffin, K
   Pagba, M
   Hall, K
   Taverna-Trani, A
   Rose, D
   Jasphy, L
   Yu, SX
   Cushner, F
   Della Valle, AG
   Cheng, J
AF Prather, Heidi
   Leupold, Olivia
   Suter, Cara
   Mehta, Nartana
   Griffin, Karen
   Pagba, Mark
   Hall, Kelyssa
   Taverna-Trani, Alessandra
   Rose, Dana
   Jasphy, Laura
   Yu, Su Xiao
   Cushner, Fred
   Della Valle, Alejandro Gonzalez
   Cheng, Jennifer
TI Early Outcomes of Orthopedic Pre-surgical Patients Enrolled in an
   Intensive, Interprofessional Lifestyle Medicine Program to Optimize
   Health
SO AMERICAN JOURNAL OF LIFESTYLE MEDICINE
LA English
DT Article; Early Access
DE lifestyle medicine; musculoskeletal; orthopedic surgery;
   lifestyle-related chronic disease; pain
ID TOTAL JOINT ARTHROPLASTY; METABOLIC SYNDROME; POSTOPERATIVE OUTCOMES;
   KNEE ARTHROPLASTY; RISK-FACTORS; TOTAL HIP; COMPLICATIONS; INFECTION;
   SURGERY; INFLAMMATION
AB Recently, lifestyle medicine (LSM) application has shown feasibility for musculoskeletal pain patients with co-existing lifestyle-related chronic diseases. This study describes early results of a LSM program for musculoskeletal patients with goals to optimize health prior to orthopedic surgery. Fifty-four patients (age: 61 +/- 11 years; 39 [72%] females) completed the program from 3/8/22-12/1/23. Data included patient goals, utilization, goal attainment, and patient outcomes. Most patients (41/54 [76%]) enrolled with established surgical dates. Mean BMI was 43.2 +/- 5.3 kg/m2, and 89% had >= 2 lifestyle-related chronic diseases. The majority reported impaired sleep (79%) and zero cumulative minutes of physical activity/week (57%). Mean program duration was 13 +/- 8 weeks involving 5 +/- 4 visits with members of the interprofessional team. Fifty-two (96%) patients successfully attained pre-program goals, and 49/54 (91%) met their surgical goal. Of the patients enrolled without surgical dates, 11/13 (85%) optimized their health and proceeded to surgery. Forty-two (78%) patients reported decreases in weight and BMI, averaging 11 +/- 7 lbs and 1.8 +/- 1.3 kg/m2, respectively. Rates of improvement in pain, PROMIS-10 physical and mental health, and PHQ-4 were 52%, 37%, 45%, and 47%, respectively. These data demonstrate the feasibility and effectiveness of a LSM program to address whole-person health optimization and enable orthopedic patients to improve lifestyle behaviors and proceed to orthopedic surgery.
C1 [Prather, Heidi; Leupold, Olivia; Pagba, Mark; Cheng, Jennifer] Hosp Special Surg, Dept Physiatry, 535 E 70th St, New York, NY 10021 USA.
   [Suter, Cara; Griffin, Karen; Taverna-Trani, Alessandra] Hosp Special Surg, Lifestyle Med Program, New York, NY USA.
   [Mehta, Nartana] Washington Univ, Div Phys Med & Rehabil, Sch Med, St Louis, MO USA.
   [Hall, Kelyssa] Hosp Special Surg, Dept Performance, New York, NY USA.
   [Rose, Dana] Hosp Special Surg, Dept Rehabil, New York, NY USA.
   [Jasphy, Laura] Hosp Special Surg, Dept Case Management, New York, NY USA.
   [Yu, Su Xiao] Hosp Special Surg, Dept Outpatient Nutr, New York, NY USA.
   [Cushner, Fred; Della Valle, Alejandro Gonzalez] Hosp Special Surg, Dept Orthoped Surg, New York, NY USA.
C3 Washington University (WUSTL)
RP Prather, H (corresponding author), Hosp Special Surg, Dept Physiatry, 535 E 70th St, New York, NY 10021 USA.
EM pratherh@hss.edu
RI Prather, Heidi/AAN-8851-2021
FU National Center for Advancing Translational Sciences of the National
   Institutes of Health [UL1TR002384]; Sorenson Family Foundation
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: REDCap use
   was supported by grant number UL1TR002384 from the National Center for
   Advancing Translational Sciences of the National Institutes of Health
   and Sorenson Family Foundation grant support for the HSS Lifestyle
   Medicine Program.
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NR 41
TC 0
Z9 0
U1 6
U2 9
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1559-8276
EI 1559-8284
J9 AM J LIFESTYLE MED
JI Am. J. Lifestyle Med.
PD 2024 MAY 16
PY 2024
DI 10.1177/15598276241252799
EA MAY 2024
PG 12
WC Public, Environmental & Occupational Health
WE Emerging Sources Citation Index (ESCI)
SC Public, Environmental & Occupational Health
GA RA4F5
UT WOS:001224932200001
PM 39554966
OA Green Published
DA 2025-06-11
ER

PT J
AU Filipcic, I
   Filipcic, IS
   Matic, K
   Lovretic, V
   Ivezic, E
   Bajic, Z
   Grosic, V
   Kezic, S
   Petrovic, BR
   Vcev, A
AF Filipcic, Igor
   Filipcic, Ivona Simunovic
   Matic, Katarina
   Lovretic, Vanja
   Ivezic, Ena
   Bajic, Zarko
   Grosic, Vladimir
   Kezic, Slobodanka
   Petrovic, Branka Restek
   Vcev, Aleksandar
TI SOMATIC COMORBIDITIES ARE INDEPENDENTLY ASSOCIATED WITH THE POOR
   HEALTH-RELATED QUALITY OF LIFE IN PSYCHIATRIC PATIENTS
SO PSYCHIATRIA DANUBINA
LA English
DT Article
DE mental disorders; somatic comorbidity; psychiatric comorbidity; quality
   of life
ID CARDIOVASCULAR RISK; MENTAL-HEALTH; METABOLIC SYNDROME; BIPOLAR
   DISORDER; SCHIZOPHRENIA; MORTALITY; PEOPLE
AB Background: Despite the increased risk, the quality of somatic healthcare is lower for patients with mental illnesses. Currently dominant approach separates physical and mental, primary and secondary healthcare. Objective of our study was to explore whether somatic comorbidities are associated with a poor HRQoL independently of some sociodemographic and clinical factors. Majority of studies have explored particular somatic and psychiatric illnesses. Therefore we decided to access the problem from the general perspective of the universe of somatic and mental illnesses in the large psychiatric institution.
   Subjects and methods: This nested cross-sectional study was done during May 2016 at Psychiatric hospital Sveti Ivan, Zagreb, Croatia on the sample of 506 patients diagnosed with psychiatric illnesses (ICD-10: F00-F99). Key outcome was the lowest 25% results on the SF-36 General health sub-scale, indicating the worst HRQoL. Predictors were all detected somatic illnesses. By multivariate logistic regression we controlled different sociodemographic, vital and clinical factors.
   Results: After adjustment for different sociodemographic and clinical factors, three somatic comorbidities remained independently associated with the worst HRQoL: endocrine, nutritional and metabolic diseases (E00-E90), diseases of respiratory system (J00-J99) and diseases of musculoskeletal system and connective tissue (M00-M99)
   Conclusions: Somatic comorbidities in psychiatric patients are associated with the poor HRQoL independently of different sociodemographic, vital and clinical factors and they should be treated seriously and integrally with mental aspects of HRQoL. Early comorbidities detection and adequate pharmacological and psychotherapeutic treatment, as well as the prevention of risk factors, may improve the quality of life and reduce morbidity and mortality of psychiatric patients.
C1 [Filipcic, Igor; Matic, Katarina; Lovretic, Vanja; Ivezic, Ena; Grosic, Vladimir; Kezic, Slobodanka; Petrovic, Branka Restek] Psychiat Hosp Sveti Ivan, Jankomir 11,Pp68, HR-10000 Zagreb, Croatia.
   [Filipcic, Igor; Grosic, Vladimir; Petrovic, Branka Restek; Vcev, Aleksandar] Josip Juraj Strossmayer Univ Osijek, Fac Med, Osijek, Croatia.
   [Filipcic, Igor] Univ Zagreb, Sch Med, Zagreb, Croatia.
   [Filipcic, Ivona Simunovic] Univ Hosp Ctr Zagreb, Dept Psychol Med, Zagreb, Croatia.
   [Bajic, Zarko] Biometrika Healthcare Res, Zagreb, Croatia.
   [Vcev, Aleksandar] Univ Hosp Ctr, Clin Internal Med, Osijek, Croatia.
C3 University of JJ Strossmayer Osijek; University of Zagreb; University of
   Zagreb; UNIVERSITY ZAGREB HOSPITAL
RP Filipcic, I (corresponding author), Psychiat Hosp Sveti Ivan, Jankomir 11,Pp68, HR-10000 Zagreb, Croatia.
EM igor.filipcic@pbsvi.hr
RI Filipčić, Ivona/AAC-8790-2019; Filipčić, Igor/ABA-8542-2020; Bajić,
   Žarko/AAE-9243-2019
OI Bajic, Zarko/0000-0002-7983-6892
FU Psychiatric hospital "Sveti Ivan", Zagreb, Croatia
FX None to declare. The study was funded by Psychiatric hospital "Sveti
   Ivan", Zagreb, Croatia.
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NR 24
TC 11
Z9 12
U1 0
U2 6
PU MEDICINSKA NAKLADA
PI ZAGREB
PA VLASKA 69, HR-10000 ZAGREB, CROATIA
SN 0353-5053
EI 1849-0867
J9 PSYCHIAT DANUB
JI Psychiatr. Danub.
PY 2016
VL 28
IS 3
BP 284
EP 292
PG 9
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA EC8OI
UT WOS:000388400900010
PM 27658838
DA 2025-06-11
ER

PT J
AU Warburton, DER
   Katzmarzyk, PT
   Rhodes, RE
   Shephard, RJ
AF Warburton, Darren E. R.
   Katzmarzyk, Peter. T.
   Rhodes, Ryan E.
   Shephard, Roy J.
TI Evidence-informed physical activity guidelines for Canadian adults
SO APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
LA English
DT Review
DE active living; chronic disease; diabetes mellitus; dose-response
   relationships; health; hypertension; ischemic heart disease; mental
   health; metabolic syndrome; mortality; obesity; osteoporosis; preventive
   medicine
ID ALL-CAUSE MORTALITY; CORONARY-HEART-DISEASE; TYPE-2 DIABETES-MELLITUS;
   BONE-MINERAL DENSITY; QUALITY-OF-LIFE; RESISTANCE TRAINING IMPROVES;
   WEIGHT-LOSS INTERVENTIONS; LONG-TERM EFFECTIVENESS; REDUCE FALL RISK;
   BODY-MASS INDEX
AB This review of the literature provides an update on the scientific biological and psychosocial bases for Canada's physical activity, guide for healthy active living, with particular reference to the effect of physical activity on the health of adults aged 20-55 years. Existing physical activity guidelines for adults from around the world are summarized briefly and compared with the Canadian guidelines. The descriptive epidemiology of physical activity and inactivity in Canada is presented, and the strength of the relationship between physical activity and specific health outcomes is evaluated, with particular emphasis on minimal and optimal physical activity requirements. Finally, areas requiring further investigation are highlighted. Summarizing the findings, Canadian and most international physical activity guidelines advocate moderate-intensity physical activity on most days of the week. Physical activity appears to reduce the risk for over 25 chronic conditions, in particular coronary heart disease, stroke, hypertension, breast cancer, colon cancer, type 2 diabetes, and osteoporosis. Current literature suggests that if the entire Canadian population followed cur-rent physical activity guidelines, approximately one third of deaths related to coronary heart disease, one quarter of deaths related to stroke and osteoporosis, 20% of deaths related to colon cancer, hypertension, and type 2 diabetes, and 14% of deaths related to breast cancer could be prevented. It also appears that the prevention of weight gain and the maintenance of weight loss require greater physical activity levels than current recommendations.
C1 [Warburton, Darren E. R.] Univ British Columbia, Cardiovasc Physiol & Rehabil Lab, Expt Med Program, Vancouver, BC V6T 1Z3, Canada.
   [Katzmarzyk, Peter. T.] Queens Univ, Sch Kinesiol & Hlth Studies, Kingston, ON K7L 3N6, Canada.
   [Rhodes, Ryan E.] Univ Victoria, Sch Exercise Sci Phys & Hlth Educ, Victoria, BC V8P 5C2, Canada.
   [Shephard, Roy J.] Univ Toronto, Fac Phys Educ & Hlth, Toronto, ON M5S 2W6, Canada.
C3 University of British Columbia; Queens University - Canada; University
   of Victoria; University of Toronto
RP Warburton, DER (corresponding author), Univ British Columbia, Cardiovasc Physiol & Rehabil Lab, Expt Med Program, 6108 Thunderbird Blvd, Vancouver, BC V6T 1Z3, Canada.
EM darren.warburton@ubc.ca
RI WARBURTON, DARREN/A-2668-2019; Katzmarzyk, Peter/N-1974-2017; Rhodes,
   Ryan/ABB-4896-2020
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NR 327
TC 163
Z9 172
U1 0
U2 34
PU CANADIAN SCIENCE PUBLISHING
PI OTTAWA
PA 65 AURIGA DR, SUITE 203, OTTAWA, ON K2E 7W6, CANADA
SN 1715-5312
EI 1715-5320
J9 APPL PHYSIOL NUTR ME
JI Appl. Physiol. Nutr. Metab.
PY 2007
VL 32
SU 2E
BP S16
EP S68
DI 10.1139/H07-123
PG 53
WC Nutrition & Dietetics; Physiology; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics; Physiology; Sport Sciences
GA 248UC
UT WOS:000252180500003
PM 18213940
OA Bronze
DA 2025-06-11
ER

PT J
AU Ruan, X
   Kubba, A
   Aguilar, A
   Mueck, AO
AF Ruan, X.
   Kubba, A.
   Aguilar, A.
   Mueck, A. O.
TI Use of cyproterone acetate/ethinylestradiol in polycystic ovary
   syndrome: rationale and practical aspects
SO EUROPEAN JOURNAL OF CONTRACEPTION AND REPRODUCTIVE HEALTH CARE
LA English
DT Review
DE Polycystic ovary syndrome; hyperandrogenism; cyproterone acetate;
   ethinylestradiol; venous thromboembolism
ID ORAL-CONTRACEPTIVES; INSULIN-RESISTANCE; ANDROGEN EXCESS; VENOUS
   THROMBOEMBOLISM; CARBOHYDRATE-METABOLISM; ETHINYL ESTRADIOL; INCREASED
   RISK; SYNDROME PCOS; WOMEN; ESTROGEN
AB Introduction: Polycystic ovary syndrome (PCOS) is a common, heterogeneous disorder characterised by hyperandrogenic skin symptoms, irregular menstruation and subfertility, increased risk of endometrial malignancy, and increased risk of preventable diseases associated with metabolic syndrome. Cyproterone acetate (CPA) 2 mg, combined with ethinylestradiol (EE) 35 mu g, is indicated for the treatment of moderate to severe acne related to androgen-sensitivity (with or without seborrhea) and/or hirsutism, in women of reproductive age.
   Objectives: To review the present knowledge about PCOS and summarize the role of CPA/EE in the care of patients suffering from this condition for the practitioner.
   Methods: Experts with clinical interest and experience in treating symptoms of androgen excess performed a non-systematic review to provide updated information regarding the use of CPA/EE in patients with PCOS.
   Results: Polycystic ovary-related hyperandrogenic skin symptoms are effectively treated by CPA/EE, reducing not only the symptoms but also their negative impact on quality of life and mental health. Proven additional benefits for these patients include the treatment of menstrual irregularities and reduction in endometrial cancer risk. Possible benefits include preservation of fertility. Treatment increases the risk for venous thromboembolic complications. The nature of other metabolic and cardiovascular long-term effects i.e., whether positive or negative, are still to be investigated.
   Conclusions: Cyproterone acetate/ethinylestradiol provides effective treatment for PCO-related hyperandrogenic skin symptoms. This efficacy and additional benefits related to menstrual irregularities and endometrial cancer risk, have to be weighed against the risk of venous thromboembolic complications based on an individual benefit/risk evaluation.
C1 [Ruan, X.; Mueck, A. O.] Capital Med Univ, Beijing Obstet & Gynecol Hosp, Dept Gynecol Endocrinol, Beijing, Peoples R China.
   [Ruan, X.; Mueck, A. O.] Univ Womens Hosp, Dept Womens Hlth, Tubingen, Germany.
   [Ruan, X.; Mueck, A. O.] Univ Clinicum Ctr Tuebingen, Res Ctr Womens Hlth, Tubingen, Germany.
   [Kubba, A.] Guys & St Thomas NHS Fdn Trust, Community Reprod & Sexual Healthcare Unit, London, England.
   [Aguilar, A.] Univ Philippines, Coll Med, Dept Obstet & Gynecol, Ctr Adv Reprod Med,St Lukes Med Ctr BGC, Manila, Philippines.
C3 Capital Medical University; Eberhard Karls University of Tubingen;
   Eberhard Karls University Hospital; Guy's & St Thomas' NHS Foundation
   Trust; University of the Philippines System; University of the
   Philippines Manila
RP Mueck, AO (corresponding author), Univ Clinicum Ctr Tuebingen, Dept Womens Hlth, Tubingen, Germany.
EM Alfred.Mueck@med.uni-tuebingen.de
OI Sison Aguilar, Angela/0000-0002-1590-2264
FU Bayer AG
FX Formation of the AWARE group and the group's meetings were supported by
   Bayer AG. Members received honoraria for attendance at meetings but no
   honoraria was paid for contributions to this manuscript. Professor Ruan
   did not attend any meetings and no honorarium was paid for her
   contribution to the manuscript. This publication and its content are
   solely the responsibility of the authors. Medical writing assistance was
   provided by Clark Health Communications under the direction of the
   authors and paid for by Bayer AG.
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NR 74
TC 23
Z9 24
U1 0
U2 7
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1362-5187
EI 1473-0782
J9 EUR J CONTRACEP REPR
JI Eur. J. Contracept. Reprod. Health Care
PY 2017
VL 22
IS 3
BP 183
EP 190
DI 10.1080/13625187.2017.1317735
PG 8
WC Public, Environmental & Occupational Health; Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health; Obstetrics & Gynecology
GA EW9NH
UT WOS:000402846000004
PM 28463030
OA hybrid
DA 2025-06-11
ER

PT J
AU Yazar, S
   Forward, H
   McKnight, CM
   Tan, A
   Soloshenko, A
   Oates, SK
   Ang, W
   Sherwin, JC
   Wood, D
   Mountain, JA
   Pennell, CE
   Hewitt, AW
   Mackey, DA
AF Yazar, Seyhan
   Forward, Hannah
   McKnight, Charlotte M.
   Tan, Alex
   Soloshenko, Alla
   Oates, Sandra K.
   Ang, Wei
   Sherwin, Justin C.
   Wood, Diane
   Mountain, Jenny A.
   Pennell, Craig E.
   Hewitt, Alex W.
   Mackey, David A.
TI Raine Eye Health Study: Design, Methodology and Baseline Prevalence of
   Ophthalmic Disease in a Birth-cohort Study of Young Adults
SO OPHTHALMIC GENETICS
LA English
DT Article
DE birth cohort study; epidemiology; participation; Raine Study;
   recruitment; young adults
ID METABOLIC SYNDROME; DIETARY PATTERNS; MENTAL-HEALTH; CHILDHOOD;
   ADOLESCENTS; ULTRASOUND
AB Purpose: The Raine Eye Health Study (REHS) was conceived to determine the prevalence of and risk factors for eye disease in young adults, and to characterize ocular biometric parameters in a young adult cohort. This article summarizes the rationale and study design of REHS and outlines the baseline prevalence of ophthalmic disease in this population.
   Methods: The Western Australian Pregnancy Cohort (Raine) Study originated as a randomized-controlled trial of 2900 women recruited from the state's largest maternity hospital. Their offspring (N = 2868) have been followed at birth, ages 1, 2, 3, 5, 8, 10, 14, 17 and 20 years of age in a prospective cohort study. DNA has been collected from participants for genome-wide association studies. At the 20-year follow-up participants completed a comprehensive eye assessment that included visual acuity, orthoptic assessment and cycloplegic autorefraction, as well as several ocular biometric variables and multiple ophthalmic photographs of the anterior and posterior segments.
   Results: A total of 1344 participants (51.3% male) were assessed over a 24-month period. For the majority of examined participants (85.5%) both parents were Caucasian, 63.3% had completed school year 12 or equivalent, 5.5% had myopia (spherical equivalent <=-3 diopters) and 15 participants (1.2%) had unilateral or bilateral pterygia. Keratoconus, cataract, keratitis and uveitis were rare.
   Conclusion: The REHS design and methodology allow comparison with other population-based studies of eye disease. The study established the prevalence of eye disorders in a large sample of predominantly Caucasian young Australian adults.
C1 [Yazar, Seyhan; Forward, Hannah; McKnight, Charlotte M.; Tan, Alex; Soloshenko, Alla; Oates, Sandra K.; Sherwin, Justin C.; Hewitt, Alex W.; Mackey, David A.] Univ Western Australia, Ctr Ophthalmol & Visual Sci, Lions Eye Inst Perth, Nedlands, WA 6009, Australia.
   [Ang, Wei; Pennell, Craig E.] Univ Western Australia, Sch Womens & Infants Hlth, Perth, WA 6009, Australia.
   [Sherwin, Justin C.] Univ Cambridge, Inst Publ Hlth, Dept Publ Hlth & Primary Care, Cambridge CB2 1TN, England.
   [Wood, Diane; Mountain, Jenny A.] Univ Western Australia, Telethon Inst Child Hlth Res, Ctr Child Hlth Res, Perth, WA 6009, Australia.
C3 Lions Eye Institute; University of Western Australia; University of
   Western Australia; University of Cambridge; University of Western
   Australia; The Kids Research Institute Australia
RP Mackey, DA (corresponding author), Univ Western Australia, Lions Eye Inst, Ctr Ophthalmol & Visual Sci, 2 Verdun St, Nedlands, WA 6009, Australia.
EM David.Mackey@lei.org.au
RI Hewitt, Alex/D-1936-2013; Pennell, Craig/ABD-6902-2020; Yazar,
   Seyhan/U-4032-2018; Pennell, Craig/C-5190-2011; Mackey AO,
   David/H-5340-2014
OI Yazar, Seyhan/0000-0003-0994-6196; Pennell, Craig/0000-0002-0937-6165;
   Tan, Alexander/0000-0002-9552-5517; Mackey AO,
   David/0000-0001-7914-4709; Hewitt, Alex/0000-0002-5123-5999
FU Australian National Health and Medical Research Council; University of
   Western Australia (UWA); Raine Medical Research Foundation; UWA Faculty
   of Medicine; Dentistry and Health Sciences
FX Initial funds for the Raine Eye Health Study pilot were provided by the
   University of Western Australia and the Australian Foundation for the
   Prevention of Blindness. We are grateful to the Australian National
   Health and Medical Research Council for the long-term contribution to
   funding the study over the last 20 years and to The University of
   Western Australia (UWA), Raine Medical Research Foundation, UWA Faculty
   of Medicine, Dentistry and Health Sciences, The Telethon Institute for
   Child Health Research, The Women and Infants Research Foundation and
   Curtin University for providing funding for Core Management.
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NR 22
TC 49
Z9 50
U1 0
U2 7
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 1381-6810
EI 1744-5094
J9 OPHTHALMIC GENET
JI Ophthalmic Genet.
PD DEC
PY 2013
VL 34
IS 4
BP 199
EP 208
DI 10.3109/13816810.2012.755632
PG 10
WC Genetics & Heredity; Ophthalmology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Genetics & Heredity; Ophthalmology
GA 251YB
UT WOS:000326969200003
PM 23301674
OA Green Published
DA 2025-06-11
ER

PT J
AU Violanti, JM
   Charles, LE
   Gu, JK
   Burchfiel, CM
   Andrew, ME
   Joseph, PN
   Dorn, JM
AF Violanti, John M.
   Charles, Luenda E.
   Gu, Ja K.
   Burchfiel, Cecil M.
   Andrew, Michael E.
   Joseph, P. Nedra
   Dorn, Joan M.
TI Depressive symptoms and carotid artery intima-media thickness in police
   officers
SO INTERNATIONAL ARCHIVES OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH
LA English
DT Article
DE Cardiovascular disease; Depression; Risk factors; Police
ID SLEEP QUALITY INDEX; RISK-FACTORS; CARDIOVASCULAR-DISEASE; METABOLIC
   SYNDROME; ATHEROSCLEROSIS RISK; PHYSICAL-ACTIVITY; NATIONAL-HEALTH;
   NEGATIVE AFFECT; NERVOUS-SYSTEM; WORK
AB Police work is a stressful occupation. Depressive symptoms, which may occur as a result of exposure to stressors in police work, have been known to be associated with an increased risk of cardiovascular disease. This cross-sectional study investigated the association between depressive symptoms and carotid artery intima-media thickness (CIMT) among police officers.
   CIMT was measured with B-mode carotid ultrasonography. Depressive symptoms were measured using the Center for Epidemiological Studies Depression (CES-D) scale. Analyses of variance and covariance were utilized to examine the mean values of common CIMT (CCA IMT) and maximum CIMT (MMXIMT) across quintiles of depressive symptoms.
   Participants included 412 officers (mean age = 41 years). Hypertension status significantly modified the association between CES-D score and CIMT. The association between CES-D score and CCA IMT was statistically significant (adjusted P = 0.030) but only among officers without hypertension. The associations between CES-D score and MMXIMT were not significant among officers with or without hypertension. Our results also showed that among officers who reported poor sleep quality, mean levels of CCA IMT, and MMXIMT tended to increase as depressive symptoms increased.
   Depressive symptoms may be therefore be independently associated with CIMT, yet masked by hypertension. Even though sleep quality did not significantly modify the main association, our results also suggest that poor sleep quality may act synergistically with depressive symptoms to increase CIMT. Future prospective work would help to clarify these associations.
C1 [Violanti, John M.] SUNY Buffalo, Sch Publ Hlth & Hlth Profess, Dept Social & Prevent Med, Buffalo, NY 14214 USA.
   [Charles, Luenda E.; Gu, Ja K.; Burchfiel, Cecil M.; Andrew, Michael E.] NIOSH, Biostat & Epidemiol Branch, Hlth Effects Lab Div, Ctr Dis Control & Prevent, Morgantown, WV USA.
   [Joseph, P. Nedra] Univ Chicago, Ctr Comprehens Canc, Epidemiol & Res Recruitment Core, Chicago, IL 60637 USA.
   [Dorn, Joan M.] SUNY Buffalo, Sch Publ Hlth & Hlth Profess, Dept Exercise & Nutr Sci, Buffalo, NY 14214 USA.
C3 State University of New York (SUNY) System; University at Buffalo, SUNY;
   Centers for Disease Control & Prevention - USA; National Institute for
   Occupational Safety & Health (NIOSH); Robert H. Lurie Comprehensive
   Cancer Center; University of Chicago; State University of New York
   (SUNY) System; University at Buffalo, SUNY
RP Violanti, JM (corresponding author), SUNY Buffalo, Sch Publ Hlth & Hlth Profess, Dept Social & Prevent Med, 270 Farber Hall, Buffalo, NY 14214 USA.
EM violanti@buffalo.edu
RI Charles, Luenda/H-6008-2011
OI /0000-0002-0245-5899
FU National Institute for Occupational Safety and Health (NIOSH)
   [200-2003-01580]
FX This work was supported by the National Institute for Occupational
   Safety and Health (NIOSH), contract no. 200-2003-01580. The findings and
   conclusions in this article are those of the authors and do not
   necessarily represent the views of the National Institute for
   Occupational Safety and Health.
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NR 51
TC 14
Z9 14
U1 0
U2 10
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0340-0131
EI 1432-1246
J9 INT ARCH OCC ENV HEA
JI Int. Arch. Occup. Environ. Health
PD NOV
PY 2013
VL 86
IS 8
BP 931
EP 942
DI 10.1007/s00420-012-0829-6
PG 12
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA 240DA
UT WOS:000326073700009
PM 23184119
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Guyon, A
   Balbo, M
   Morselli, LL
   Tasali, E
   Leproult, R
   L'Hermite-Baleriaux, M
   Van Cauter, E
   Spiegel, K
AF Guyon, A.
   Balbo, M.
   Morselli, L. L.
   Tasali, E.
   Leproult, R.
   L'Hermite-Baleriaux, M.
   Van Cauter, E.
   Spiegel, K.
TI Adverse Effects of Two Nights of Sleep Restriction on the
   Hypothalamic-Pituitary-Adrenal Axis in Healthy Men
SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Article
ID LEPTIN LEVELS; INSUFFICIENT SLEEP; INSULIN-RESISTANCE; GENE-EXPRESSION;
   FOOD-INTAKE; CORTISOL; STRESS; APPETITE; DURATION; IMPACT
AB Context: Insufficient sleep is associated with increased cardiometabolic risk. Alterations in hypothalamic-pituitary-adrenal axis may underlie this link.
   Objective: Our objective was to examine the impact of restricted sleep on daytime profiles of ACTH and cortisol concentrations.
   Methods: Thirteen subjects participated in 2 laboratory sessions (2 nights of 10 hours in bed versus 2 nights of 4 hours in bed) in a randomized crossover design. Sleep was polygraphically recorded. After the second night of each session, blood was sampled at 20-minute intervals from 9:00 AM to midnight to measure ACTH and total cortisol. Saliva was collected every 20 minutes from 2:00 PM to midnight to measure free cortisol. Perceived stress, hunger, and appetite were assessed at hourly intervals by validated scales.
   Results: Sleep restriction was associated with a 19% increase in overall ACTH levels (P < .03) that was correlated with the individual amount of sleep loss (r(Sp) = 0.63, P < .02). Overall total cortisol levels were also elevated (+21%; P = .10). Pulse frequency was unchanged for both ACTH and cortisol. Morning levels of ACTH were higher after sleep restriction (P < .04) without concomitant elevation of cortisol. In contrast, evening ACTH levels were unchanged while total and free cortisol increased by, respectively, 30% (P < .03) and 200% (P < .04). Thus, the amplitude of the circadian cortisol decline was dampened by sleep restriction (-21%; P < .05). Sleep restriction was not associated with higher perceived stress but resulted in an increase in appetite that was correlated with the increase in total cortisol.
   Conclusion: The impact of sleep loss on hypothalamic-pituitary-adrenal activity is dependent on time of day. Insufficient sleep dampens the circadian rhythm of cortisol, a major internal synchronizer of central and peripheral clocks.
C1 [Guyon, A.; Spiegel, K.] Univ Lyon 1, Unite Mixte Rech 1028, Integrated Physiol & Physiol Brain Arousal Syst, F-69008 Lyon, France.
   [Balbo, M.] Azienda Sanit Osped Santi Antonio & Biagio & Cesa, I-15100 Alessandria, Italy.
   [Morselli, L. L.; Tasali, E.; Leproult, R.; L'Hermite-Baleriaux, M.] Univ Chicago, Dept Med, Sleep Metab & Hlth Ctr, Chicago, IL 60637 USA.
   [Leproult, R.] Univ Libre Bruxelles, Neuropsychol & Funct Neuroimaging Res Unit, Ctr Res Cognit, B-1050 Brussels, Belgium.
   [Leproult, R.] Univ Libre Bruxelles, Neurosci & ULB Neurosci Inst, B-1050 Brussels, Belgium.
   [L'Hermite-Baleriaux, M.] Univ Libre Bruxelles, Fac Med, B-1070 Brussels, Belgium.
C3 Universite Claude Bernard Lyon 1; Azienda Ospedaliera SS Antonio Biagio
   Cesare Arrigo; University of Chicago; Universite Libre de Bruxelles;
   Universite Libre de Bruxelles; Universite Libre de Bruxelles
RP Spiegel, K (corresponding author), Univ Lyon 1, Fac Med Lyon Est, Ctr Rech Neurosci Lyon, INSERM,Unite Mixte Rech 5292,U1028, 8 Ave Rockefeller, F-69373 Lyon, France.
EM karine.spiegel@univ-lyon1.fr
RI Spiegel, Karine/H-4456-2017; Morselli, Lisa/I-6465-2013
OI Morselli, Lisa L./0000-0003-0514-329X; Spiegel,
   Karine/0000-0003-0193-0886
FU National Institutes of Health [P01 AG-11412, P60 DK-20595,
   UL1-TR000430]; WAKINGTeam; Lyon Neuroscience Research Center; Inserm
   Unite Mixte de Recherche [U1028-CNRS, 5292]; Claude Bernard University,
   Lyon, France; French Society for Research Sleep Medicine; Brussels
   Institute for Research and Innovation (Belgium); Philips/Respironics;
   ResMed Foundation; Amylin/Bristol Meyers Squibb; Viropharma/Shire and
   Vanda Pharmaceuticals; Associate Editor for the journal SLEEP; Sleep
   Loss and Obesity: Intersecting Epidemics published by Springer Science
   Business, LLC
FX The work described in this article was supported by National Institutes
   of Health Grants P01 AG-11412, P60 DK-20595, and UL1-TR000430 to the
   University of Chicago and by the WAKINGTeam, Lyon Neuroscience Research
   Center, Inserm U1028-CNRS Unite Mixte de Recherche 5292, Claude Bernard
   University, Lyon, France. A.G. was supported by a fellowship from the
   French Society for Research & Sleep Medicine. R.L. is currently a
   recipient of a grant, "Brains Back to Brussels," from the Brussels
   Institute for Research and Innovation (Belgium). The funding sources had
   no role in the design, conduct, or reporting of this study.Disclosure
   Summary: A.G., M.B., L.M., E.T., R.L., M.L.-B., and K.S. have nothing to
   declare. E.V.C. receives grant support from Philips/Respironics, the
   ResMed Foundation, and Amylin/Bristol Meyers Squibb; is a consultant for
   Viropharma/Shire and Vanda Pharmaceuticals, an Associate Editor for the
   journal SLEEP and for a volume entitled Sleep Loss and Obesity:
   Intersecting Epidemics published by Springer Science & Business, LLC;
   and serves as an expert witness for Lamson, Dugan, and Murray, LLP
   (Omaha, NE).
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NR 42
TC 78
Z9 85
U1 0
U2 19
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0021-972X
EI 1945-7197
J9 J CLIN ENDOCR METAB
JI J. Clin. Endocrinol. Metab.
PD AUG
PY 2014
VL 99
IS 8
BP 2861
EP 2868
DI 10.1210/jc.2013-4254
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA AP8PO
UT WOS:000342341200060
PM 24823456
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Mangurian, C
   Schillinger, D
   Newcomer, JW
   Vittinghoff, E
   Essock, S
   Zhu, Z
   Dyer, W
   Schmittdiel, J
AF Mangurian, Christina
   Schillinger, Dean
   Newcomer, John W.
   Vittinghoff, Eric
   Essock, Susan
   Zhu, Zheng
   Dyer, Wendy
   Schmittdiel, Julie
TI Diabetes Screening among Antipsychotic-Treated Adults with Severe Mental
   Illness in an Integrated Delivery System: A Retrospective Cohort Study
SO JOURNAL OF GENERAL INTERNAL MEDICINE
LA English
DT Article
DE diabetes screening; severe mental illness; quality of care
ID CARDIOMETABOLIC RISK; CARE; SCHIZOPHRENIA; DISORDERS; MEDICATIONS;
   MANAGEMENT; BARRIERS; SMOKING; RECORDS; PEOPLE
AB Severe mental illness (SMI) is associated with increased risk for type 2 diabetes, partly due to adverse metabolic effects of antipsychotic medications. In public health care settings, annual screening rates are 30%. We measured adherence to national diabetes screening guidelines for patients taking antipsychotic medications.
   To estimate diabetes screening prevalence among patients with SMI within an integrated health care system, and to assess characteristics associated with lack of screening.
   Retrospective cohort study.
   Antipsychotic-treated adults with SMI. We excluded participants with known diabetes.
   Primary outcome was screening via fasting glucose test or hemoglobin A1c during a 1-year period.
   In 2014, 16,754 patients with SMI diagnoses were receiving antipsychotics. Seventy-four percent of these patients' providers ordered diabetes screening tests that year, but only 55% (9247/16,754) received screening. When the observation time frame was extended to 2 years, 73% (12,250/16,754) were screened. Adjusting for sex and race/ethnicity, young adults (aged 18-29 years) were less likely to receive screening than older age groups [adjusted RR (aRR) 1.23-1.57, p < 0.0001]. Compared to whites, screening was more common for Asians (aRR 1.141, 95% CI 1.089-1.195, p < 0.0001), less common for blacks (aRR 0.946, 95% CI 0.898-0.997, p < 0.0375), and no different for Hispanics (aRR 1.030, 95% CI 0.988-1.074, p = 0.165). Smokers were less likely to be screened than non-smokers (aRR 0.93, 95% CI 0.89-0.97, p < 0.0008). Utilization of either mental health or primary care services increased the likelihood of screening.
   While almost three-fourths of adults with SMI taking antipsychotic medications received a lab order for diabetes screening, only 55% received screening within a 12-month period. Young adults and smokers were less likely to be screened, despite their disproportionate metabolic risk. Future studies should assess the barriers and facilitators with regard to diabetes screening in this vulnerable population at the patient, provider, and system levels.
C1 [Mangurian, Christina] Univ Calif San Francisco, Dept Psychiat, Weill Inst Neurosci, San Francisco, CA 94143 USA.
   [Mangurian, Christina; Schillinger, Dean] Zuckerberg San Francisco Gen Hosp, UCSF Ctr Vulnerable Populat, San Francisco, CA USA.
   [Schillinger, Dean] Zuckerberg San Francisco Gen Hosp, UCSF Div Gen Internal Med, San Francisco, CA USA.
   [Newcomer, John W.] Florida Atlantic Univ, Charles E Schmidt Coll Med, Boca Raton, FL 33431 USA.
   [Vittinghoff, Eric] UCSF Dept Epidemiol & Biostat, San Francisco, CA USA.
   [Essock, Susan] Columbia Univ, Dept Psychiat, New York, NY USA.
   [Essock, Susan] New York State Psychiat Inst & Hosp, New York, NY 10032 USA.
   [Zhu, Zheng; Dyer, Wendy; Schmittdiel, Julie] Kaiser Permanente Northern Calif, Div Res, Oakland, CA USA.
C3 University of California System; University of California San Francisco;
   State University System of Florida; Florida Atlantic University;
   Columbia University; New York State Psychiatry Institute; Kaiser
   Permanente
RP Mangurian, C (corresponding author), Univ Calif San Francisco, Dept Psychiat, Weill Inst Neurosci, San Francisco, CA 94143 USA.
EM christina.mangurian@ucsf.edu
OI Newcomer, John/0000-0003-2153-9382
FU NIH National Institute of Diabetes and Digestive and Kidney Diseases
   (NIDDK) [R03 DK101857]; NIH Career Development Award [K23MH093689];
   Otsuka America Pharmaceutical, Inc.; Health Delivery Systems Center for
   Diabetes Translational Research [P30 DK092924-01]; NIH Center grant
   [P60MD006902]
FX All authors received support from a grant from the NIH National
   Institute of Diabetes and Digestive and Kidney Diseases (NIDDK; R03
   DK101857). CM was supported by an NIH Career Development Award
   (K23MH093689). JN has grant support from Otsuka America Pharmaceutical,
   Inc. JS and DS received support from the Health Delivery Systems Center
   for Diabetes Translational Research (P30 DK092924-01). DS also received
   support from NIH Center grant P60MD006902. The remaining authors have no
   disclosures. The contents of this publication are solely the
   responsibility of the authors and do not necessarily represent the
   official views of the NIH.
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NR 29
TC 20
Z9 24
U1 1
U2 1
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0884-8734
EI 1525-1497
J9 J GEN INTERN MED
JI J. Gen. Intern. Med.
PD JAN
PY 2018
VL 33
IS 1
BP 79
EP 86
DI 10.1007/s11606-017-4205-9
PG 8
WC Health Care Sciences & Services; Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services; General & Internal Medicine
GA FS1JT
UT WOS:000419532800018
PM 29090381
OA Green Published
DA 2025-06-11
ER

PT J
AU Qin, ZS
   Yu, YP
   Gu, HQ
   Shi, DD
   Wang, Z
   Wu, JN
   Furukawa, T
   Wu, YF
AF Qin, Zongshi
   Yu, Yongpei
   Gu, Hongqiu
   Shi, Dongdong
   Wang, Zhen
   Wu, Jiani
   Furukawa, Toshiaki
   Wu, Yangfeng
TI SAS macro programme for Bang's Blinding Index to assess and visualise
   the success of blinding in randomised controlled trials
SO GENERAL PSYCHIATRY
LA English
DT Review
DE statistics as topic; double-blind method; biostatistics
ID CURRENT THERAPY
AB This paper aims to present a Statistical Analysis Software (SAS) macro %BBIplus, offering estimation and visualisation methods for the Bang's Blinding Index (BBI) for randomised controlled trials (RCTs) with various designs. We developed the SAS macro programme %BBIplus to facilitate the implementation of BBI. This user-friendly programme allows for easy and rapid estimation and visualisation of BBI across different scenarios, including pairwise comparison RCTs with two arms, double-dummy design RCTs with three arms and factorial design RCTs with four arms. The programme requires no pre-existing data set, and users only need to input the number of individuals of correct, uncertain or wrong guesses in each intervention or control group. We illustrate the functionality of %BBIplus using blinding assessment data from three previously published RCTs: BBR (adjunctive berberine reduces antipsychotic-associated weight gain and metabolic syndrome in patients with schizophrenia: a randomised controlled trial), SELECT-TDCS (the sertraline versus electrical current therapy for treating depression clinical study: results from a factorial, randomised controlled trial) and ELECT-TDCS (trial of electrical direct-current therapy versus escitalopram for depression) studies. The programme estimates the BBI for each arm, providing point estimates, 95% CI and associated p values. Additionally, %BBIplus can visualise the estimations through forest plots and make the judgement for the success of blinding easily and rapidly. This tool caters to the needs of clinical trial investigators, offering a comprehensive solution for estimating and visualising the blinding index under various RCT designs.
C1 [Qin, Zongshi; Yu, Yongpei; Wu, Yangfeng] Peking Univ, Clin Res Inst, Beijing, Peoples R China.
   [Gu, Hongqiu] Capital Med Univ, Beijing Tiantan Hosp, Dept Neurol, Beijing, Peoples R China.
   [Gu, Hongqiu] Capital Med Univ, Beijing Tiantan Hosp, China Natl Clin Res Ctr Neurol Dis, Beijing, Peoples R China.
   [Shi, Dongdong; Wang, Zhen] Shanghai Jiao Tong Univ, Shanghai Mental Hlth Ctr, Sch Med, Shanghai, Peoples R China.
   [Wu, Jiani] China Acad Chinese Med Sci, Guanganmen Hosp, Dept Acupuncture & Neurol, Beijing, Peoples R China.
   [Furukawa, Toshiaki] Kyoto Univ, Dept Hlth Promot & Human Behav, Grad Sch Med, Kyoto, Japan.
   [Furukawa, Toshiaki] Sch Publ Hlth, Kyoto, Japan.
C3 Peking University; Capital Medical University; Capital Medical
   University; Shanghai Jiao Tong University; Guang'anmen Hospital, CACMS;
   China Academy of Chinese Medical Sciences; Kyoto University
RP Wu, YF (corresponding author), Peking Univ, Clin Res Inst, Beijing, Peoples R China.; Wu, JN (corresponding author), China Acad Chinese Med Sci, Guanganmen Hosp, Dept Acupuncture & Neurol, Beijing, Peoples R China.; Furukawa, T (corresponding author), Kyoto Univ, Dept Hlth Promot & Human Behav, Grad Sch Med, Kyoto, Japan.; Furukawa, T (corresponding author), Sch Publ Hlth, Kyoto, Japan.
EM qinzs_pucri@hsc.pku.edu.cn; yuyp_pucri@bjmu.edu.cn; guhongqiu@yeah.net;
   laural.dong.shi@gmail.com; wangzhen@smhc.org.cn; jiani_wu@aliyun.com;
   furukawa@kuhp.kyoto-u.ac.jp; wuyf@bjmu.edu.cn
RI SHI, Dongdong/ABE-9487-2021; Gu, Hongqiu/K-5009-2019; Wang,
   Zhen/A-2389-2011; Qin, Zongshi/ABE-2821-2021
OI Qin, Zongshi/0000-0001-5888-461X; Wang, Zhen/0000-0003-4319-5314
FU International Postdoctoral Exchange Fellowship Program [YJ20220238];
   China Postdoctoral Science Foundation [2023TQ0018]
FX This study was funded by International Postdoctoral Exchange Fellowship
   Program (YJ20220238), China Postdoctoral Science Foundation
   (2023TQ0018).
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NR 21
TC 0
Z9 0
U1 2
U2 2
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2096-5923
EI 2517-729X
J9 GEN PSYCHIAT
JI Gen. Psychiat.
PD DEC 6
PY 2024
VL 37
IS 6
AR e101578
DI 10.1136/gpsych-2024-101578
PG 8
WC Psychiatry
WE Emerging Sources Citation Index (ESCI)
SC Psychiatry
GA O5Q1G
UT WOS:001371658600001
PM 39660039
OA gold
DA 2025-06-11
ER

PT J
AU Liu, JT
   Fan, YG
   Song, J
   Song, R
   Li, XX
   Liu, L
   Wei, N
   Yuan, JJ
   Yi, WZ
   Pan, RB
   Jin, XY
   Cheng, J
   Zhang, XL
   Su, H
AF Liu, Jintao
   Fan, Yinguang
   Song, Jian
   Song, Rong
   Li, Xuanxuan
   Liu, Li
   Wei, Ning
   Yuan, Jiajun
   Yi, Weizhuo
   Pan, Rubing
   Jin, Xiaoyu
   Cheng, Jian
   Zhang, Xulai
   Su, Hong
TI Impaired thyroid hormone sensitivity exacerbates the effect of PM
   2.5 and its components on dyslipidemia in schizophrenia
SO SCIENCE OF THE TOTAL ENVIRONMENT
LA English
DT Article
DE PM2.5 components; Schizophrenia; Dyslipidemia; Thyroid function
ID AIR-POLLUTION; CARDIOMETABOLIC RISK; INFLAMMATION; ASSOCIATION;
   PREVALENCE; MECHANISMS; REGRESSION; EXPOSURE; LIPIDS; CHINA
AB Background Dyslipidemia in schizophrenia causes a serious loss of healthy life expectancy, making it imperative to explore key environmental risk factors. We aimed to assess the effect of PM2.5 and its constituents on dyslipidemia in schizophrenia, identify the critical hazardous components, and investigate the role of impaired thyroid hormones (THs) sensitivity in this association. Methods We collected disease data on schizophrenia from the Anhui Mental Health Center from 2019 to 2022. Logistic regression was constructed to explore the effect of average annual exposure to PM2.5 and its components [black carbon (BC), organic matter (OM), sulfate (SO42-), ammonium (NH4+), and nitrate (NO3-)] on dyslipidemia, with subgroup analyses for age and gender. The degree of impaired THs sensitivity in participants was reflected by the Thyroid Feedback Quantile-based Index (TFQI), and its role in the association of PM2.5 components with dyslipidemia was explored. Results A total of 5125 patients with schizophrenia were included in this study. Exposure to PM2.5 and its components (BC, OM, SO42-, NH4+, and NO3-) were associated with dyslipidemia with the odds ratios and 95 % confidence interval of 1.13 (1.04, 1.23), 1.16 (1.07, 1.26), 1.15 (1.06, 1.25), 1.11 (1.03, 1.20), 1.09 (1.00, 1.18), 1.12 (1.04, 1.20), respectively. Mixed exposure modeling indicated that BC played a major role in the effects of the mixture. More significant associations were observed in males and groups <45 years. In addition, we found that the effect of PM2.5 and its components on dyslipidemia was exacerbated as impaired THs sensitivity in the patients. Conclusions Exposure to PM2.5 and its components is associated with an increased risk of dyslipidemia in schizophrenia, which may be exacerbated by impaired THs sensitivity. Our results suggest a new perspective for the management of ambient particulate pollution and the protection of thyroid function in schizophrenia.
C1 [Liu, Jintao; Fan, Yinguang; Song, Jian; Song, Rong; Li, Xuanxuan; Liu, Li; Wei, Ning; Yuan, Jiajun; Yi, Weizhuo; Pan, Rubing; Jin, Xiaoyu; Cheng, Jian; Su, Hong] Anhui Med Univ, Sch Publ Hlth, Dept Epidemiol & Hlth Stat, Hefei, Anhui, Peoples R China.
   [Liu, Jintao; Fan, Yinguang; Song, Jian; Song, Rong; Li, Xuanxuan; Liu, Li; Wei, Ning; Yuan, Jiajun; Yi, Weizhuo; Pan, Rubing; Jin, Xiaoyu; Cheng, Jian; Su, Hong] Ctr Big Data & Populat Hlth IHM, Hefei, Anhui, Peoples R China.
   [Liu, Jintao; Fan, Yinguang; Song, Jian; Song, Rong; Li, Xuanxuan; Liu, Li; Wei, Ning; Yuan, Jiajun; Yi, Weizhuo; Pan, Rubing; Jin, Xiaoyu; Cheng, Jian; Su, Hong] Inflammat & Immune Mediated Dis Lab Anhui Prov, Hefei, Anhui, Peoples R China.
   [Liu, Jintao; Fan, Yinguang; Song, Jian; Song, Rong; Li, Xuanxuan; Liu, Li; Wei, Ning; Yuan, Jiajun; Yi, Weizhuo; Pan, Rubing; Jin, Xiaoyu; Cheng, Jian; Zhang, Xulai; Su, Hong] Anhui Med Univ, Psychol Hosp, Anhui Mental Hlth Ctr, Hefei, Anhui, Peoples R China.
C3 Anhui Medical University; Anhui Medical University
RP Su, H (corresponding author), Anhui Med Univ, Sch Publ Hlth, Dept Epidemiol & Hlth Stat, Hefei, Anhui, Peoples R China.; Zhang, XL; Su, H (corresponding author), Anhui Med Univ, Psychol Hosp, Anhui Mental Hlth Ctr, Hefei, Anhui, Peoples R China.
EM xulaizhang@ahmhcentre.com; suhong5151@sina.com
RI Li, xuanxuan/KRO-4942-2024; liu, yiman/GXN-2487-2022; Pan,
   Rubing/AAM-1806-2021
FU National Natural Science Foundation of China [42375184]; Research Funds
   of Center for Big Data and Population Health of IHM [JKS2022011];
   Natural Science Research Key Project of the University of Anhui Province
   [2023AH050652]
FX <BOLD>Funding</BOLD> This study was funded by the National Natural
   Science Foundation of China (Grant No. 42375184) , the Research Funds of
   Center for Big Data and Population Health of IHM (Grant No. JKS2022011)
   , and the Natural Science Research Key Project of the University of
   Anhui Province (Grant No. 2023AH050652) .
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NR 52
TC 1
Z9 1
U1 5
U2 10
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0048-9697
EI 1879-1026
J9 SCI TOTAL ENVIRON
JI Sci. Total Environ.
PD OCT 1
PY 2024
VL 945
AR 174055
DI 10.1016/j.scitotenv.2024.174055
EA JUN 2024
PG 9
WC Environmental Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology
GA XG9O4
UT WOS:001260650000001
PM 38889814
DA 2025-06-11
ER

PT J
AU Shah, K
   Mellars, L
   Changolkar, A
   Feldman, SR
AF Shah, Kamal
   Mellars, Lillian
   Changolkar, Arun
   Feldman, Steven R.
TI Real-world burden of comorbidities in US patients with psoriasis
SO JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
LA English
DT Article
DE comorbidity; database; disease burden; MarketScan; medical insurance
   claims; psoriasis
ID METABOLIC SYNDROME; MYOCARDIAL-INFARCTION; CASE DEFINITIONS; REPORTING
   BIAS; PREVALENCE; RISK; DISEASE; DEPRESSION; INFECTION; DATABASES
AB Background: Understanding background comorbidity rates in psoriasis can provide perspective for adverse events associated with new therapies.
   Objective: We sought to assess the extent of comorbidities in psoriasis patients by use of the Truven Health Analytics MarketScan database.
   Methods: MarketScan, comprising commercial claims representative of a large US-insured population, had 1.22 million patients with >= 1 claim with a psoriasis diagnosis between January 1, 2008, and December 31, 2014. Patients >= 18 years of age who had >= 2 health claims in any diagnosis field for psoriasis (International Classification of Diseases, 9th Revision, Clinical Modification 696.1) with a psoriasis diagnosis (index) date between July 1, 2008, and June 30, 2014, were included to allow follow-up observation time.
   Results: Prevalence and incidence of 24 comorbidities were assessed in 469,097 psoriasis patients; the most common comorbidities were hyperlipidemia (45.64% and 30.83%, respectively), hypertension (42.19% and 24.19%), depression (17.91% and 12.68%), type 2 diabetes mellitus (17.45% and 8.44%), and obesity (14.38% and 11.57%).
   Limitations: A limitation of the study was that only a certain insured population was represented.
   Conclusions: Comorbidity rates align with those described in the literature and support the concept that psoriasis patients have high rates of cardiometabolic comorbidities. This analysis highlights the potential utility of very large insurance databases for determining comorbidity prevalence in psoriasis, which may aid health care providers in managing psoriasis.
C1 [Shah, Kamal; Changolkar, Arun] EMD Serono Inc, Billerica, MA 01821 USA.
   [Mellars, Lillian] Celgene Corp, Summit, NJ USA.
   [Feldman, Steven R.] Wake Forest Univ, Bowman Gray Sch Med, Dept Dermatol, Winston Salem, NC 27103 USA.
C3 Merck KGaA; EMD Serono Inc.; Bristol-Myers Squibb; Celgene Corporation;
   Wake Forest University; Wake Forest Baptist Medical Center
RP Shah, K (corresponding author), EMD Serono Inc, Global Drug Safety, 45 A Middlesex Turnpike A204, Billerica, MA 01821 USA.
EM dr.kamal.s.shah@gmail.com
RI Feldman, Steven/AAH-6971-2021
OI Shah, Kamal/0009-0007-3137-8320
FU Celgene Corporation
FX This study was sponsored by Celgene Corporation. The authors received
   editorial support in the preparation of the manuscript from Peloton
   Advantage, LLC, funded by Celgene Corporation. The authors, however,
   wrote, directed, and are fully responsible for all content and editorial
   decisions related to the development of the manuscript.
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NR 29
TC 69
Z9 71
U1 1
U2 4
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0190-9622
J9 J AM ACAD DERMATOL
JI J. Am. Acad. Dermatol.
PD AUG
PY 2017
VL 77
IS 2
BP 287
EP +
DI 10.1016/j.jaad.2017.03.037
PG 10
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA FA2VF
UT WOS:000405298300027
PM 28623046
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Meroni, M
   Longo, M
   Dongiovanni, P
   Paolini, E
AF Meroni, Marica
   Longo, Miriam
   Dongiovanni, Paola
   Paolini, Erika
TI A narrative review about cognitive impairment in Metabolic
   Dysfunction-Associated Steatotic Liver Disease (MASLD): Another matter
   to face through a holistic approach
SO JOURNAL OF ADVANCED RESEARCH
LA English
DT Review
DE MASLD; Cognitive decline; Holistic; Genetics; Microbiota
ID TYPE-2 DIABETES-MELLITUS; APOLIPOPROTEIN-E; PHYSICAL-ACTIVITY; GUT
   MICROBIOME; BRAIN; RISK; ADULTS; PERMEABILITY; PERFORMANCE; MECHANISMS
AB Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic hepatic disorder worldwide in both adults and children. It is well established that MASLD represents the hepatic manifestation of the metabolic syndrome whose definition includes the presence of obesity, type 2 diabetes (T2D), dyslipidemia, hypertension and hypercoagulability. All these conditions contribute to a chronic inflammatory status which may impact on blood brain barrier (BBB) integrity leading to an impaired function of central nervous system (CNS). Aim of review: Since the mechanisms underlying the brain-liver-gut axis derangement are still inconclusive, the present narrative review aims to make a roundup of the most recent studies regarding the cognitive decline in MASLD also highlighting possible therapeutic strategies to reach a holistic advantage for the patients. Key Scientific Concepts of Review: Due to its ever-growing prevalence, the MASLD-related mental dysfunction represents an enormous socio-economic burden since it largely impacts on the quality of life of patients as well as on their working productivity. Indeed, cognitive decline in MASLD translates in low concentration and processing speed, reduced memory, sleepiness but also anxiety and depression. Chronic systemic inflammation, hyperammonemia, genetic background and intestinal dysbiosis possibly contribute to the cognitive decline in MASLD patients. However, its diagnosis is still underestimated since the leading mechanisms are multi-faceted and unexplained and do not exist standardized diagnostic tools or cognitive test strategies. In this scenario, nutritional and lifestyle interventions as well as intestinal microbiota manipulation (probiotics, fecal transplantation) may represent new approaches to counteract mental impairment in these subjects. In sum, to face the "mental aspect" of this multifactorial disease which is almost unexplored, cognitive tools should be introduced in the management of MASLD patients. (c) 2023 The Authors. Published by Elsevier B.V. on behalf of Cairo University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
C1 [Meroni, Marica; Longo, Miriam; Dongiovanni, Paola; Paolini, Erika] Fdn IRCCS Ca Granda Osped Maggiore Policlin, Med & Metab Dis, Via Francesco Sforza 35, I-20122 Milan, Italy.
C3 IRCCS Ca Granda Ospedale Maggiore Policlinico
RP Dongiovanni, P (corresponding author), Fdn IRCCS Ca Granda Osped Maggiore Policlin, Med & Metab Dis, Via Francesco Sforza 35, I-20122 Milan, Italy.
EM paola.dongiovanni@policlinico.mi.it
RI Dongiovanni, Paola/AAC-9965-2019; Paolini, Erika/AAT-3907-2021; Longo,
   Miriam/AAB-3817-2019; meroni, marica/K-8621-2018
OI Dongiovanni, Paola/0000-0003-4343-7213; meroni,
   marica/0000-0002-4161-4178
FU Italian Ministry of Health [GR-2019-12370172, RF-2021-12374481]; The
   5x1000 2020-Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico
   [RC5100020B]
FX This study was supported by Italian Ministry of Health (Ricerca Corrente
   2023-Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico) , by
   Italian Ministry of Health (Ricerca Finalizzata Min-istero della Salute
   GR-2019-12370172; RF-2021-12374481) and by 5x1000 2020-Fondazione IRCCS
   Ca Granda Ospedale Maggiore Policlinico (RC5100020B) .
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NR 113
TC 7
Z9 7
U1 4
U2 7
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2090-1232
EI 2090-1224
J9 J ADV RES
JI J. Adv. Res.
PD FEB
PY 2025
VL 68
BP 231
EP 240
DI 10.1016/j.jare.2024.02.007
EA JAN 2025
PG 10
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA W1S6J
UT WOS:001416461400001
PM 38369241
OA gold
DA 2025-06-11
ER

PT J
AU Putra, IGNE
   Daly, M
   Sutin, A
   Steptoe, A
   Scholes, S
   Robinson, E
AF Putra, I. Gusti Ngurah Edi
   Daly, Michael
   Sutin, Angelina
   Steptoe, Andrew
   Scholes, Shaun
   Robinson, Eric
TI Obesity, psychological well-being related measures, and risk of seven
   non-communicable diseases: evidence from longitudinal studies of UK and
   US older adults
SO INTERNATIONAL JOURNAL OF OBESITY
LA English
DT Article
ID C-REACTIVE PROTEIN; CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; ANXIETY
   DISORDERS; WEIGHT STIGMA; BODY-FAT; ASSOCIATION; DEPRESSION;
   METAANALYSIS; DISCRIMINATION
AB Background We examined the role of psychological well-being related measures in explaining the associations between obesity and increased risk of non-communicable diseases (NCDs: hypertension, heart disease, stroke, diabetes, arthritis, cancer, and memory-related disease) in older adults.Methods Data were from the English Longitudinal Study of Ageing (ELSA), UK (baseline: Wave 4-2008/2009; n = 8127) and the Health and Retirement Study (HRS), US (baseline: Waves 9 and 10-2008/2010; n = 12,477). Objective body mass index was used to define obesity. A range of psychological well-being related measures (e.g., depressive symptoms, life satisfaction) was available in ELSA (n = 7) and HRS (n = 15), and an index of overall psychological well-being was developed separately in each study. NCDs were from a self-reported doctor diagnosis and/or other assessments (e.g., biomarker data) in both studies; and in ELSA, NCDs from linked hospital admissions data were examined. Longitudinal associations between obesity status, psychological well-being measures, and NCDs were examined using Cox proportional hazard models (individual NCDs) and Poisson regression (a cumulative number of NCDs). Mediation by psychological well-being related measures was assessed using causal mediation analysis.Results Obesity was consistently associated with an increased prospective risk of hypertension, heart disease, diabetes, arthritis, and a cumulative number of NCDs in both ELSA and HRS. Worse overall psychological well-being (index measure) and some individual psychological well-being related measures were associated with an increased prospective risk of heart disease, stroke, arthritis, memory-related disease, and a cumulative number of NCDs across studies. Findings from mediation analyses showed that neither the index of overall psychological well-being nor any individual psychological well-being related measures explained (mediated) why obesity increased the risk of developing NCDs in both studies.Conclusion Obesity and psychological well-being may independently and additively increase the risk of developing NCDs.
C1 [Putra, I. Gusti Ngurah Edi; Robinson, Eric] Univ Liverpool, Inst Populat Hlth, Dept Psychol, Liverpool, England.
   [Daly, Michael] Maynooth Univ, Dept Psychol, Maynooth, Ireland.
   [Sutin, Angelina] Florida State Univ, Dept Behav Sci & Social Med, Coll Med, Tallahassee, FL USA.
   [Steptoe, Andrew; Scholes, Shaun] UCL, Inst Epidemiol & Hlth Care, Fac Populat Hlth Sci, Dept Epidemiol & Hlth, London, England.
C3 University of Liverpool; Maynooth University; State University System of
   Florida; Florida State University; University of London; University
   College London
RP Putra, IGNE (corresponding author), Univ Liverpool, Inst Populat Hlth, Dept Psychol, Liverpool, England.
EM i.gusti.ngurah.edi.putra@liverpool.ac.uk
RI Steptoe, Andrew/Y-2440-2019; Scholes, Shaun/JDD-7382-2023; Putra, I
   Gusti Ngurah Edi/AAG-2836-2020
OI Steptoe, Andrew/0000-0001-7808-4943; Scholes, Shaun/0000-0002-7865-5264;
   Putra, I Gusti Ngurah Edi/0000-0002-1014-6949; Robinson,
   Eric/0000-0003-3586-5533
FU Economic and Social Research Council (ESRC), United Kingdom Research and
   Innovation (UKRI);  [ES/V017594/1]
FX This work received funding from the Economic and Social Research Council
   (ESRC), a part of the United Kingdom Research and Innovation (UKRI)
   (ES/V017594/1). The views stated in this work are of the authors only.
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NR 60
TC 11
Z9 11
U1 4
U2 12
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0307-0565
EI 1476-5497
J9 INT J OBESITY
JI Int. J. Obes.
PD SEP
PY 2024
VL 48
IS 9
BP 1283
EP 1291
DI 10.1038/s41366-024-01551-1
EA JUN 2024
PG 9
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA D8U0B
UT WOS:001236516400001
PM 38824226
OA hybrid
DA 2025-06-11
ER

PT J
AU Adams, C
   Stears, A
   Savage, D
   Deaton, C
AF Adams, Claire
   Stears, Anna
   Savage, David
   Deaton, Christi
TI "We're stuck with what we've got": The impact of lipodystrophy on body
   image
SO JOURNAL OF CLINICAL NURSING
LA English
DT Article
DE anxiety; body image and sexuality; depression; diabetes; emotional
   distress; endocrine disorders; femininity and daily life; health
   psychology; metabolic syndrome
ID QUALITY-OF-LIFE; MANAGEMENT; DISFIGUREMENT; PERCEPTIONS; ADHERENCE;
   DIAGNOSIS; RARE
AB Aims and objectivesTo evaluate the impact of lipodystrophy on body image and how this affects patients' daily lives.
   BackgroundLipodystrophy refers to a group of rare conditions characterised by generalised or partial lack of body fat and is associated with severe metabolic problems, for example, severe insulin resistance, diabetes and pancreatitis. In addition to its metabolic effect, lack of adipose tissue may have a major impact on appearance and cause distressing physical changes. While global research has focused on diagnosis and management, there is no published work investigating the psychological effects of lipodystrophy on body image.
   MethodsFollowing ethical approval, participants with lipodystrophy were purposively sampled from the National Severe Insulin Resistance Service in Cambridge, UK, and invited to take part in a semi-structured interview. Eleven (10 female, one male) interviews were conducted and digitally recorded. Data were analysed using an inductive thematic approach.
   ResultsFour main themes were identified in the data set; Always feeling appearance was different, a better understanding of lipodystrophy is needed, feeling accepted and there's more to lipodystrophy than managing symptoms. Participants spoke of distressing cosmetic effects related to lack of fat tissue and other changes related to lipodystrophy, contributing to negative body image. For some, negative body image led to feelings of worthlessness impacting daily life and adherence to treatment. Psychological support was lacking but desired by participants.
   ConclusionLipodystrophy contributes to negative body image affecting patients' daily lives. Patients wanted psychological support alongside medical management. Further research is needed to determine how best to deliver psychological support and to evaluate its impact on well-being and metabolic management.
   Relevance to clinical practiceThe effects of rare diseases such as lipodystrophy on appearance can be distressing for patients. Support beyond medical management is needed to improve patients' daily lives and help them to live well with appearance-altering conditions.
C1 [Adams, Claire; Savage, David] Univ Cambridge, Metab Res Labs, Addenbrookes Treatment Ctr, Wellcome Trust MRC Inst Metab Sci,Addenbrookes Ho, Cambridge, England.
   [Adams, Claire; Stears, Anna] Cambridge Univ Hosp NHS Fdn Trust, Natl Severe Insulin Resistance Serv, Addenbrookes Treatment Ctr, Cambridge, England.
   [Deaton, Christi] Univ Cambridge, Sch Clin Med, Natl Severe Insulin Resistance Serv, Cambridge Inst Publ Hlth, Cambridge, England.
C3 University of Cambridge; University of Cambridge; University of
   Cambridge
RP Adams, C (corresponding author), Univ Cambridge, Metab Res Labs, Addenbrookes Treatment Ctr, Wellcome Trust MRC Inst Metab Sci,Addenbrookes Ho, Cambridge, England.
EM ca337@medschl.cam.ac.uk
RI O'Rahilly, Stephen/ABF-6509-2020; Adams, Claire/ABE-8004-2021; Deaton,
   Christi/F-6485-2010
OI Deaton, Christi/0000-0003-3209-0752
FU Addenbrooke's Charitable Trust
FX This research was funded by the Addenbrooke's Charitable Trust and was
   conducted as part of a National Institute of Health Research Masters in
   Clinical Research studentship.
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NR 45
TC 25
Z9 25
U1 0
U2 8
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0962-1067
EI 1365-2702
J9 J CLIN NURS
JI J. Clin. Nurs.
PD MAY
PY 2018
VL 27
IS 9-10
BP 1958
EP 1968
DI 10.1111/jocn.14342
PG 11
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA GI1KB
UT WOS:000434128200021
PM 29516553
DA 2025-06-11
ER

PT J
AU Carlson, BX
   Ketter, TA
   Sun, W
   Timko, K
   McQuade, RD
   Sanchez, R
   Vester-Blokland, E
   Marcus, R
AF Carlson, Berit X.
   Ketter, Terence A.
   Sun, Wei
   Timko, Karen
   McQuade, Robert D.
   Sanchez, Raymond
   Vester-Blokland, Estelle
   Marcus, Ronald
TI Aripiprazole in combination with lamotrigine for the long-term treatment
   of patients with bipolar I disorder (manic or mixed): a randomized,
   multicenter, double-blind study (CN138-392)
SO BIPOLAR DISORDERS
LA English
DT Article
DE aripiprazole; bipolar disorder; efficacy; safety
ID PLACEBO-CONTROLLED TRIAL; LITHIUM MAINTENANCE TREATMENT; CONTROLLED
   18-MONTH TRIAL; PARTIAL AGONIST; ANTIPSYCHOTIC ARIPIPRAZOLE; ADJUNCTIVE
   ARIPIPRAZOLE; DEPRESSED-PATIENTS; METABOLIC SYNDROME; MOOD STABILIZER;
   RATING-SCALE
AB Objectives: To evaluate the efficacy and safety of aripiprazole (ARI) plus lamotrigine (LTG) compared with placebo (PBO) plus LTG, for long-term treatment in bipolar I disorder patients with a recent manic/mixed episode.
   Methods: After a 9-24 week stabilization phase receiving single-blind ARI (10-30 mg/day) plus open-label LTG (100 or 200 mg/day), patients maintaining stability (Young Mania Rating Scale/Montgomery-Asberg Depression Rating Scale total scores <= 12) with ARI + LTG for eight consecutive weeks were randomized to continue on double-blind ARI + LTG or to receive PBO + LTG, after removing ARI from ARI + LTG treatment, and followed up for 52 weeks. The primary outcome measure was time from randomization to relapse into a manic/mixed episode.
   Results: A total of 787 patients entered the stabilization phase, and 351 were randomized to ARI + LTG (n = 178) or PBO + LTG (n = 173). ARI + LTG yielded a numerically longer time to manic/mixed relapse than PBO + LTG, but it was not statistically significant [hazard ratio (HR) = 0.55; 95% confidence interval (CI): 0.30-1.03; p = 0.058]. The estimated relapse rates at Week 52 were 11% for ARI + LTG and 23% for PBO + LTG, yielding a number needed-to-treat of nine (95% CI: 5-121). The three most common adverse events were akathisia [10.8%, 6.1% for ARI + LTG and PBO + LTG, respectively; number neededto- harm (NNH) = 22], insomnia (7.4%, 11.5%), and anxiety (7.4%, 3.6%). Mean weight change was 0.43 kg and -1.81 kg, respectively (last observation carried forward, p = 0.001). Rates of >= 7% weight gain with ARI + LTG and PBO + LTG were 11.9% and 3.5%, respectively (NNH = 12).
   Conclusions: ARI + LTG delayed the time to manic/mixed relapse but did not reach statistical significance. Safety and tolerability results revealed no unexpected adverse events for ARI combination with LTG.
C1 [Carlson, Berit X.; Sun, Wei; Vester-Blokland, Estelle] Bristol Myers Squibb Co, Plainsboro, NJ 08540 USA.
   [Ketter, Terence A.] Stanford Univ, Sch Med, Dept Psychiat & Behav Sci, Stanford, CA 94305 USA.
   [Timko, Karen; Marcus, Ronald] Bristol Myers Squibb Co, Wallingford, CT 06492 USA.
   [McQuade, Robert D.; Sanchez, Raymond] Otsuka Pharmaceut Dev & Commercializat Inc, Princeton, NJ USA.
C3 Bristol-Myers Squibb; Stanford University; Bristol-Myers Squibb; Otsuka
   Pharmaceutical
RP Carlson, BX (corresponding author), Bristol Myers Squibb Co, 777 Scudders Mill Rd,Mailstop 14-14, Plainsboro, NJ 08540 USA.
EM berit.carlson@bms.com
RI McQuade, Robert/J-6107-2019
FU Bristol-Myers Squibb (Princeton, NJ, USA); Otsuka Pharmaceutical Co.,
   Ltd. (Tokyo, Japan); Bristol-Myers Squibb; Abbott Labs; AstraZeneca;
   Cephalon; Eli Lilly Co.; GlaxoSmithKline; Pfizer; Repligen; Wyeth;
   Astellas Pharmaceuticals; Dainippon Sumitomo Pharmaceuticals; Janssen;
   Jazz; Novartis; Organon; Solvay; Valeant; Vanda; XenoPort
FX This study was supported by Bristol-Myers Squibb (Princeton, NJ, USA)
   and Otsuka Pharmaceutical Co., Ltd. (Tokyo, Japan). The authors would
   like to thank the protocol development committee for their expert advice
   on CN138-392: Charles L. Bowden, M. D., Mark A. Frye, M. D., Paul E.
   Keck, Jr., M. D., Robert M. A. Hirschfeld, M. D., Gary S. Sachs, M. D.,
   and Prakash S. Masand, M. D. Editorial support for the preparation of
   this manuscript was provided by Ogilvy Healthworld Medical Education;
   funding was provided by Bristol-Myers Squibb.BXC, WS, KT, EV-B, and RM
   are employees of Bristol-Myers Squibb. TAK has received grant/research
   support from Abbott Labs, AstraZeneca, Bristol-Myers Squibb, Cephalon,
   Eli Lilly & Co., GlaxoSmithKline, Pfizer, Repligen, and Wyeth; has
   received consulting fees from Abbott Labs, AstraZeneca, Astellas
   Pharmaceuticals, Bristol-Myers Squibb, Cephalon, Dainippon Sumitomo
   Pharmaceuticals, Eli Lilly & Co., GlaxoSmithKline, Janssen, Jazz,
   Novartis, Organon, Solvay, Valeant, Vanda, Wyeth, and XenoPort; has
   received lecture honoraria from Abbott Labs, AstraZeneca, Bristol-Myers
   Squibb, Eli Lilly & Co., GlaxoSmithKline, Noven, Otsuka, and Pfizer; and
   his wife is an employee of Johnson & Johnson and owns Johnson & Johnson
   stock. RDM and RS are employees of Otsuka Pharmaceutical Development &
   Commercialization, Inc.
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NR 43
TC 46
Z9 48
U1 0
U2 9
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1398-5647
J9 BIPOLAR DISORD
JI Bipolar Disord.
PD FEB
PY 2012
VL 14
IS 1
BP 41
EP 53
DI 10.1111/j.1399-5618.2011.00974.x
PG 13
WC Clinical Neurology; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Psychiatry
GA 894SU
UT WOS:000300448000005
PM 22329471
DA 2025-06-11
ER

PT J
AU Serrao, R
   Piñero, C
   Velez, J
   Coutinho, D
   Maltez, F
   Lino, S
   Castro, RSE
   Tavares, AP
   Pacheco, P
   Lopes, MJ
   Mansinho, K
   Miranda, AC
   Neves, I
   de Abreu, RC
   Almeida, J
   Pássaro, L
AF Serrao, Rosario
   Pinero, Carmela
   Velez, Jorge
   Coutinho, Daniel
   Maltez, Fernando
   Lino, Sara
   Sarmento e Castro, Rui
   Tavares, Ana Paula
   Pacheco, Patricia
   Lopes, Maria Joao
   Mansinho, Kamal
   Miranda, Ana Claudia
   Neves, Isabel
   de Abreu, Ricardo Correia
   Almeida, Joana
   Passaro, Leonor
TI Non-AIDS-related comorbidities in people living with HIV-1 aged 50 years
   and older: The AGING POSITIVE study
SO INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
LA English
DT Article
DE Aging; HIV-1 infection; Non-AIDS comorbidities
ID METABOLIC SYNDROME; INFECTED PERSONS; RISK-FACTORS; PREVALENCE;
   INDIVIDUALS; MORBIDITY; MORTALITY; EFFICACY; OUTCOMES; BURDEN
AB Objective: To characterize the profile of non-AIDS-related comorbidities (NARC) in the older HIV-1-infected population and to explore the factors associated with multiple NARC.
   Methods: This was a multicentre, cross-sectional study including HIV-1-infected patients aged >= 50 years, who were virologically suppressed and had been on a stable antiretroviral therapy (ART) regimen for at least 6 months. A multiple regression model explored the association between demographic and clinical variables and the number of NARC.
   Results: Overall, 401 patients were enrolled. The mean age of the patients was 59.3 years and 72.6% were male. The mean duration of HIV-1 infection was 12.0 years and the median exposure to ART was 10.0 years. The mean number of NARC was 2.1, and 34.7% of patients had three or more NARC. Hypercholesterolemia was the most frequent NARC (60.8%), followed by arterial hypertension (39.7%) and chronic depression/anxiety (23.9%). Arterial hypertension and diabetes mellitus were the most frequently treated NARC (95.6% and 92.6% of cases, respectively). The linear regression analysis showed a positive relationship between age and NARC (B = 0.032, 95% confidence interval 0.015-0.049; p = 0.0003) and between the duration of HIV-1 infection and NARC (B = 0.039, 95% confidence interval 0.017-0.059; p = 0.0005).
   Conclusions: A high prevalence of NARC was found, the most common being metabolic, cardiovascular, and psychological conditions. NARC rates were similar to those reported for the general population, suggesting a larger societal problem beyond HIV infection. A multidisciplinary approach is essential to reduce the burden of complex multi-morbid conditions in the HIV-1-infected population. (c) 2018 Merck Sharp & Dohme Corp and The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
C1 [Serrao, Rosario; Pinero, Carmela] Ctr Hosp Sao Joao, Dept Infect Dis, Porto, Portugal.
   [Velez, Jorge; Coutinho, Daniel] Ctr Hosp Baixo Vouga, Dept Infect Dis, Aveiro, Portugal.
   [Maltez, Fernando; Lino, Sara] Hosp Curry Cabral, Ctr Hosp Lisboa Cent, Dept Infect Dis, Lisbon, Portugal.
   [Sarmento e Castro, Rui; Tavares, Ana Paula] Ctr Hosp Porto, Dept Infect Dis, Porto, Portugal.
   [Pacheco, Patricia; Lopes, Maria Joao] Hosp Prof Doutor Fernando Fonseca EPE, Dept Infect Dis, Amadora, Portugal.
   [Mansinho, Kamal; Miranda, Ana Claudia] Hosp Egas Moniz, Ctr Hosp Lisboa Ocident, Dept Infect Dis, Lisbon, Portugal.
   [Neves, Isabel; de Abreu, Ricardo Correia] Dept Infect Dis, Unidade Local Saude Matosinhos, Matosinhos, Portugal.
   [Almeida, Joana; Passaro, Leonor] MSD Lda, Edificio Vasco da Gama 19, P-2770192 Paco De Arcos, Portugal.
C3 Sao Joao Hospital; Universidade de Aveiro; Universidade de Lisboa;
   Centro Hospitalar de Lisboa Central, EPE; Hospital Professor Doutor
   Fernando Fonseca, EPE; Egas Moniz Hospital; Centro Hospitalar de Lisboa
   Ocidental, EPE
RP Almeida, J (corresponding author), MSD Lda, Edificio Vasco da Gama 19, P-2770192 Paco De Arcos, Portugal.
EM rosarioserrao@chsj.min-saude.pt; maria.calvo@chsj.min-saude.pt;
   11346@chbv.min-saude.pt; Daniel.Coutinho.18237@chbv.min-saude.pt;
   fmaltez@chlc.min-saude.pt; sara.lino@chlc.min-saude.pt;
   rsarmento@chporto.min-saude.pt; anaprat@chporto.min-saude.pt;
   patricia.p.pacheco@hff.min-saude.pt; maria.lopes@hff.min-saude.pt;
   kmansinho@chlo.min-saude.pt; amiranda@chlo.min-saude.pt;
   isabel.neves@ulsm.min-saude.pt; correia.abreu@ulsm.min-saude.pt;
   joana.almeida@merck.com; leonor.passaro@merck.com
RI Coutinho, Daniel/S-9558-2019; Miranda, Ana Catarina/D-4742-2009;
   Almeida, Joana/GMX-4849-2022
OI Lopes, Maria Joao/0000-0001-8805-7244; Maltez,
   Fernando/0000-0001-5828-7727; Serrao, Rosario/0000-0002-3030-1205
FU Merck Sharp & Dohme, Lda, Portugal [MK0518-826]
FX Merck Sharp & Dohme, Lda, Portugal provided financial support for the
   non-interventional study (Protocol Nr. MK0518-826).
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NR 52
TC 49
Z9 51
U1 0
U2 6
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1201-9712
EI 1878-3511
J9 INT J INFECT DIS
JI Int. J. Infect. Dis.
PD FEB
PY 2019
VL 79
BP 94
EP 100
DI 10.1016/j.ijid.2018.10.011
PG 7
WC Infectious Diseases
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Infectious Diseases
GA HJ4EV
UT WOS:000457127700018
PM 30529370
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU De Hert, M
   Dekker, JM
   Wood, D
   Kahl, KG
   Holt, RIG
   Möller, HJ
AF De Hert, M.
   Dekker, J. M.
   Wood, D.
   Kahl, K. G.
   Holt, R. I. G.
   Moeller, H. -J.
TI Cardiovascular disease and diabetes in people with severe mental illness
   position statement from the European Psychiatric Association (EPA),
   supported by the European Association for the Study of Diabetes (EASD)
   and the European Society of Cardiology (ESC)
SO EUROPEAN PSYCHIATRY
LA English
DT Review
DE Severe mental illness; Schizophrenia; Depression; Bipolar disorder;
   Physical health; Weight gain
ID INDUCED WEIGHT-GAIN; CATIE SCHIZOPHRENIA TRIAL; LIFE-STYLE INTERVENTION;
   ISCHEMIC-HEART-DISEASE; METABOLIC SYNDROME; ATYPICAL ANTIPSYCHOTICS;
   SCHIZOAFFECTIVE DISORDER; 2ND-GENERATION ANTIPSYCHOTICS; INSULIN
   SENSITIVITY; SEVERE DYSLIPIDEMIA
AB People with severe mental illnesses, such as schizophrenia, depression or bipolar disorder, have worse physical health and reduced life expectancy compared to the general population. The excess cardiovascular mortality associated with schizophrenia and bipolar disorder is attributed in part to an increased risk of the modifiable coronary heart disease risk factors; obesity, smoking, diabetes, hypertension and dyslipidaemia. Antipsychotic medication and possibly other psychotropic medication like antidepressants can induce weight gain or worsen other metabolic cardiovascular risk factors. Patients may have limited access to general healthcare with less opportunity for cardiovascular risk screening and prevention than would be expected in a non-psychiatric population. The European Psychiatric Association (EPA), supported by the European Association for the Study of Diabetes (EASD) and the European Society of Cardiology (ESC) published this statement with the aim of improving the care of patients suffering from severe mental illness. The intention is to initiate cooperation and shared care between the different healthcare professionals and to increase the awareness of psychiatrists and primary care physicians caring for patients with severe mental illness to screen and treat cardiovascular risk factors and diabetes. (C) 2009 Elsevier Masson SAS. All rights reserved.
C1 [De Hert, M.] Ctr Catholic Univ, Univ Psychiat, Leuven Campus Kortenberg,Leuvensesteenweg 517, B-3070 Kortenberg, Belgium.
   [Dekker, J. M.] Vrije Univ Amsterdam, Med Ctr, Dept Epidemiol & Biostat, NL-1081 BT Amsterdam, Netherlands.
   [Dekker, J. M.] Vrije Univ Amsterdam, Med Ctr, EMGO, Inst Hlth & Care Res, NL-1081 BT Amsterdam, Netherlands.
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   [Moeller, H. -J.] Univ Munich, Dept Psychiat, D-80336 Munich, Germany.
C3 Vrije Universiteit Amsterdam; Vrije Universiteit Amsterdam; Imperial
   College London; Hannover Medical School; University of Southampton;
   University of Munich
RP De Hert, M (corresponding author), Ctr Catholic Univ, Univ Psychiat, Leuven Campus Kortenberg,Leuvensesteenweg 517, B-3070 Kortenberg, Belgium.
EM marc.de.hert@uc-kortenberg.be
RI Moeller, Hans-Juergen/ACL-2968-2022; De Hert, Marc/AAH-6090-2021
OI De Hert, Marc/0000-0003-4255-5920
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NR 140
TC 685
Z9 722
U1 0
U2 61
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0924-9338
EI 1778-3585
J9 EUR PSYCHIAT
JI Eur. Psychiat.
PD SEP
PY 2009
VL 24
IS 6
SI SI
BP 412
EP 424
DI 10.1016/j.eurpsy.2009.01.005
PG 13
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 502GW
UT WOS:000270445800010
PM 19682863
DA 2025-06-11
ER

PT J
AU Martin, S
   Atlantis, E
   Wilson, D
   Lange, K
   Haren, MT
   Taylor, A
   Wittert, G
AF Martin, Sean
   Atlantis, Evan
   Wilson, David
   Lange, Kylie
   Haren, Matthew T.
   Taylor, Anne
   Wittert, Gary
CA Florey Adelaide Male Ageing Study
TI Clinical and Biopsychosocial Determinants of Sexual Dysfunction in
   Middle-Aged and Older Australian Men
SO JOURNAL OF SEXUAL MEDICINE
LA English
DT Article
DE Erectile Dysfunction; Epidemiology; Physiopathology; Libido; Decreased
ID MALE ERECTILE DYSFUNCTION; DEPRESSIVE SYMPTOMS; ALCOHOL-CONSUMPTION;
   METABOLIC SYNDROME; RISK-FACTORS; COMMUNITY; DESIRE; TESTOSTERONE;
   ASSOCIATION; INVENTORY
AB Introduction. Erectile dysfunction (ED) and other related sexual dysfunctions in men have recently been shown to associate with a range of conditions and biopsychosocial factors. However, few studies have been able to control for these related factors simultaneously. Aim. To determine the prevalence of and associated risk factors for ED and low solitary and dyadic sexual desire. Main Outcome Measures. Erectile function (International Index of Erectile Function-erectile function) and sexual desire (Sexual Desire Inventory 2), as well as associated sociodemographic, lifestyle, biological, and clinical risk factors. Methods. Data were collected from 1,195 randomly selected, community-dwelling men as part of the Florey Adelaide Male Ageing Study. Results. The prevalence of ED, low solitary, and dyadic sexual desire was 17.7%, 67.7%, and 13.5%, respectively. Increasing age, abdominal fat mass, obstructive sleep apnea risk, and the absence of a regular partner were associated with both degrees of ED severity. Insufficient physical activity, low alcohol consumption, and hypertension were associated with mild ED only, and voiding lower urinary tract symptoms, diabetes, and lower plasma testosterone were independently associated with moderate to severe ED. Increasing age, lower alcohol consumption, insufficient physical activity, and a diagnosis of depression, anxiety, or insomnia were associated with both low dyadic and solitary sexual desire. Postschool qualifications and lower plasma testosterone were associated with low dyadic desire, whereas lower education and income, unemployment, and migration were associated with low solitary sexual desire. The absence of a regular partner and postschool qualifications were associated with higher solitary sexual desire. Conclusions. While ED and low dyadic and solitary sexual desire share some risk factors, we were able to demonstrate that unique factors exist for each of these domains. Attention should first be given to addressing these modifiable risk factors. Martin S, Atlantis E, Wilson D, Lange K, Haren MT, Taylor A, Wittert G, and Members of the Florey Adelaide Male Ageing Study. Clinical and biopsychosocial determinants of sexual dysfunction in middle-aged and older Australian men. J Sex Med 2012;9:20932103.
C1 [Martin, Sean; Taylor, Anne] Univ Adelaide, Discipline Med, Populat Res & Outcomes Study Unit, Adelaide, SA 5005, Australia.
   [Martin, Sean; Atlantis, Evan; Wilson, David; Haren, Matthew T.; Wittert, Gary] Univ Adelaide, Freemasons Fdn Ctr Mens Hlth, Adelaide, SA 5005, Australia.
   [Haren, Matthew T.] Univ S Australia, SANSOM Inst, Div Hlth Sci, Adelaide, SA 5001, Australia.
C3 University of Adelaide; University of Adelaide; University of South
   Australia
RP Martin, S (corresponding author), Univ Adelaide, Discipline Med, Populat Res & Outcomes Study Unit, Lv 6,Eleanor Harrald Bldg,Frome Rd, Adelaide, SA 5005, Australia.
EM sean.martin@adelaide.edu.au
RI Lange, Kylie/D-8082-2013; Atlantis, Evan/ABC-8075-2021; wittert,
   gary/AAE-2398-2019; Taylor, Anne/F-5708-2010; Haren, Matthew/A-3191-2008
OI Taylor, Anne/0000-0002-4422-7974; Haren, Matthew/0000-0003-2464-4364
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NR 52
TC 28
Z9 32
U1 0
U2 13
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1743-6095
EI 1743-6109
J9 J SEX MED
JI J. Sex. Med.
PD AUG
PY 2012
VL 9
IS 8
BP 2093
EP 2103
DI 10.1111/j.1743-6109.2012.02805.x
PG 11
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Urology & Nephrology
GA 982BQ
UT WOS:000307017100014
PM 22759388
DA 2025-06-11
ER

PT J
AU Carrasco-Wong, I
   Längst, G
   Sobrevia, L
   Casanello, P
AF Carrasco-Wong, Ivo
   Laengst, Gernot
   Sobrevia, Luis
   Casanello, Paola
TI Nrf2 pre-recruitment at Enhancer 2 is a hallmark of
   H2O2-induced epigenetic transcriptional memory in
   the HMOX1 gene in human umbilical artery endothelial cells
SO JOURNAL OF CELLULAR PHYSIOLOGY
LA English
DT Article
DE epigenetics; HMOX1; human endothelium; NRF2; oxidative stress;
   transcriptional memory
ID HEME OXYGENASE-1; OXIDATIVE STRESS; NITRIC-OXIDE; WEIGHT-GAIN;
   INDUCTION; PROMOTER; REPRESSION; GENERATION; RESISTANCE; CHROMATIN
AB Maternal obesity (MO) is a significant cause of increased cardiometabolic risk in offspring, who present endothelial dysfunction at birth. Alterations in physiologic and cellular redox status are strongly associated with altered gene regulation in arterial endothelium. However, specific mechanisms by which the pro-oxidant fetal environment in MO could modulate the vascular gene expression and function during the offspring's postnatal life are elusive. We tested if oxidative stress could reprogram the antioxidant-coding gene's response to a pro-oxidant challenge through an epigenetic transcriptional memory (ETM) mechanism. A pro-oxidant double-hit protocol was applied to human umbilical artery endothelial cells (HUAECs) and EA.hy 926 endothelial cell lines. The ETM acquisition in the HMOX1 gene was analyzed by RT-qPCR. HMOX1 mRNA decay was evaluated by Actinomycin-D treatment and RT-qPCR. To assess the chromatin accessibility and the enrichment of NRF2, RNAP2, and phosphorylation at serin-5 of RNAP2, at HMOX1 gene regulatory regions, were used DNase HS-qPCR and ChIP-qPCR assays, respectively. The CpG methylation pattern at the HMOX1 core promoter was analyzed by DNA bisulfite conversion and Sanger sequencing. Data were analyzed using two-way ANOVA, and p < 0.05 was statistically significant. Using a pro-oxidant double-hit protocol, we found that the Heme Oxygenase gene (HMOX1) presents an ETM response associated with changes in the chromatin structure at the promoter and gene regulatory regions. The ETM response was characterized by a paused-RNA Polymerase 2 and NRF2 enrichment at the transcription start site and Enhancer 2 of the HMOX1 gene, respectively. Changes in DNA methylation pattern at the HMOX1 promoter were not a hallmark of this oxidative stress-induced ETM. These data suggest that a pro-oxidant milieu could trigger an ETM at the vascular level, indicating a potential epigenetic mechanism involved in the increased cardiovascular risk in the offspring of women with obesity.
C1 [Carrasco-Wong, Ivo] Univ San Sebastian, Med & Sci Fac, Sch Med Technol, Cellular Signaling & Differentiat Lab CSDL, Santiago, Chile.
   [Laengst, Gernot] Univ Regensburg, Biochem Ctr Regensburg BCR, Biochem 3, Regensburg, Germany.
   [Sobrevia, Luis] Pontificia Univ Catolica Chile, Fac Med, Cellular & Mol Physiol Lab CMPL, Div Obstet & Gynecol,Sch Med,Dept Obstet, Santiago 8330024, Chile.
   [Sobrevia, Luis] Univ Seville, Fac Pharm, Dept Physiol, Seville, Spain.
   [Sobrevia, Luis] Sao Paulo State Univ UNESP, Fac Med, Med Sch, Sao Paulo, SP, Brazil.
   [Sobrevia, Luis] Univ Queensland, Univ Queensland Ctr Clin Res UQCCR, Fac Med & Biomed Sci, Brisbane, Qld, Australia.
   [Sobrevia, Luis; Casanello, Paola] Univ Groningen, Univ Med Ctr Groningen UMCG, Dept Pathol & Med Biol, Div Pathol, Groningen, Netherlands.
   [Sobrevia, Luis] Inst Obes Res, Fac Excellence, Sch Med & Hlth Sci, Monterrey, Nuevo Leon, Mexico.
   [Sobrevia, Luis] Tecnol Monterrey, Monterrey, Nuevo Leon, Mexico.
   [Casanello, Paola] Pontificia Univ Catolica Chile, Sch Med, Dept Neonatol, Santiago, Chile.
   [Casanello, Paola] Pontificia Univ Catolica Chile, Sch Med, Dept Obstet, Santiago, Chile.
C3 Universidad San Sebastian; University of Regensburg; Pontificia
   Universidad Catolica de Chile; University of Sevilla; Universidade
   Estadual Paulista; University of Queensland; University of Groningen;
   Tecnologico de Monterrey; Tecnologico de Monterrey; Pontificia
   Universidad Catolica de Chile; Pontificia Universidad Catolica de Chile
RP Carrasco-Wong, I (corresponding author), Univ San Sebastian, Med & Sci Fac, Sch Med Technol, Cellular Signaling & Differentiat Lab CSDL, Santiago, Chile.; Casanello, P (corresponding author), Pontificia Univ Catolica Chile, Sch Med, Dept Neonatol, Santiago, Chile.
EM ivo.carrasco@uss.cl; pcasane@uc.cl
RI Sobrevia, Luis/H-9608-2016; Längst, Gernot/G-5287-2015; Carrasco-Wong,
   Ivo/S-5521-2019; Casanello, Paola/X-7443-2019
OI Casanello, Paola/0000-0002-2355-1476; Sobrevia,
   Luis/0000-0001-5802-2243; Carrasco-Wong, Ivo/0000-0003-1020-734X
FU Chilean Fondo Nacional de Desarrollo Cientifico y Tecnologico [1171406,
   1221812]; Agencia Nacional de Investigacion y Desarrollo;  [SA77210087]
FX Chilean Fondo Nacional de Desarrollo Cientifico y Tecnologico,
   Grant/Award Numbers: 1171406, 1221812; Agencia Nacional de Investigacion
   y Desarrollo,Grant/Award Number: SA77210087
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NR 58
TC 0
Z9 0
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0021-9541
EI 1097-4652
J9 J CELL PHYSIOL
JI J. Cell. Physiol.
PD NOV
PY 2024
VL 239
IS 11
DI 10.1002/jcp.31243
EA MAR 2024
PG 13
WC Cell Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Physiology
GA L8J2U
UT WOS:001181839100001
PM 38465708
DA 2025-06-11
ER

PT J
AU Patel, P
   Rosen, CF
   Chandran, V
   Ye, YJ
   Gladman, DD
AF Patel, Priya
   Rosen, Cheryl F.
   Chandran, Vinod
   Ye, Yang Justine
   Gladman, Dafna D.
TI Addressing comorbidities in psoriatic disease
SO RHEUMATOLOGY INTERNATIONAL
LA English
DT Article
DE Psoriatic arthritis; Psoriasis; Hypertension; Cardiovascular disease;
   Diabetes; Hyperlipidemia; Psoriasis
ID TO-SEVERE PSORIASIS; QUALITY-OF-LIFE; MANAGING COMORBIDITIES; ARTHRITIS;
   RISK; MODERATE; RECOMMENDATIONS; PREVALENCE; MANAGEMENT; KNOWLEDGE
AB Psoriasis and PsA are associated with comorbidities including cardiovascular disease, obesity, metabolic syndrome and depression. The purpose of this study was to examine if patients recognize that they are being monitored for comorbidities associated with their condition, and to determine which physicians are managing these comorbidities. Patients with psoriasis without arthritis (PsC) and patients with PsA were recruited from the University of Toronto Psoriasis Cohort and Psoriatic Arthritis Clinic, respectively. A comorbidity questionnaire was developed through a literature review and patients completed the questionnaire at clinic visits or over the telephone. PsA patient responses were compared with information recorded by physicians at clinic visits. A total of 268 patients (103 PsC and 164 PsA) were included. Patients indicated having their blood pressure (96.3%), weight (94.4%), blood sugar (75%) and cholesterol (79.5%) levels checked, with PsA patients indicating being checked more frequently than PsC patients. PsA patients were most uncertain about whether their blood sugar and cholesterol levels were checked by physicians. The highest correlation between patient responses and physician records occurred for medications for diabetes, depression and hypercholesterolemia. Patients indicated their family physician were most responsible in monitoring the comorbidities. Overall, patients documented being moderately well screened for most comorbidities and were most unsure about having their blood sugar and cholesterol levels monitored. Patient education and records should be improved at clinic visits, as there are discrepancies between patient responses and physician records regarding the presence and treatment of comorbidities.
C1 [Patel, Priya; Chandran, Vinod; Ye, Yang Justine] Univ Hlth Network, Krembil Res Inst, Ctr Prognosis Studies Rheumat Dis, Toronto, ON, Canada.
   [Rosen, Cheryl F.] Univ Toronto, Toronto Western Hosp, Div Dermatol, Dept Med, Toronto, ON, Canada.
   [Chandran, Vinod] Univ Toronto, Dept Med & Lab Med, Toronto, ON, Canada.
   [Chandran, Vinod] Univ Toronto, Dept Pathobiol, Toronto, ON, Canada.
   [Chandran, Vinod] Univ Toronto, Inst Med Sci, Toronto, ON, Canada.
   [Gladman, Dafna D.] Univ Toronto, Toronto, ON, Canada.
   [Gladman, Dafna D.] Krembil Res Inst, Toronto, ON, Canada.
   [Gladman, Dafna D.] Univ Hlth Network, Psoriat Dis Program, Toronto, ON, Canada.
   [Gladman, Dafna D.] Toronto Western Hosp, Ctr Prognosis Studies Rheumat Dis, 399 Bathurst St,1E-410B, Toronto, ON M5T 2S8, Canada.
C3 University of Toronto; University Health Network Toronto; Krembil
   Research Institute; University of Toronto; University Health Network
   Toronto; University of Toronto; University of Toronto; University of
   Toronto; University of Toronto; Krembil Research Institute; University
   of Toronto; University Health Network Toronto; University of Toronto;
   University Health Network Toronto
RP Gladman, DD (corresponding author), Univ Toronto, Toronto, ON, Canada.; Gladman, DD (corresponding author), Krembil Res Inst, Toronto, ON, Canada.; Gladman, DD (corresponding author), Univ Hlth Network, Psoriat Dis Program, Toronto, ON, Canada.; Gladman, DD (corresponding author), Toronto Western Hosp, Ctr Prognosis Studies Rheumat Dis, 399 Bathurst St,1E-410B, Toronto, ON M5T 2S8, Canada.
EM dafna.gladman@utoronto.ca
RI Gladman, Dafna/AFM-6487-2022
OI Chandran, Vinod/0000-0002-8297-0275
FU Canadian Rheumatology Association-Pfizer Clinical Summer Studentship
   award; Abbvie Corporation; Amgen; Abbvie; Celgene; Eli Lilly; Novartis;
   UCB; Pfizer
FX Ms. Priya Patel was supported by the Canadian Rheumatology
   Association-Pfizer Clinical Summer Studentship award. Other than this
   award, Ms. Patel declares no conflict of interest regarding this paper.
   Dr. Cheryl Rosen has received speaker honorarium from Abbvie, Celgene,
   Janssen, Novartis and Eli Lilly. Dr. Rosen however declares no conflict
   of interest regarding this paper. Dr. Vinod Chandran has received a
   Grant funding from Abbvie Corporation and speaker honorarium from Amgen,
   Abbview, Celgene, Janssen, Novartis, Pfizer, UCB and Eli Lilly. Dr.
   Chandran however declares no conflict of interest regarding this paper.
   Ms. Yang Justine Ye declares that she has no conflict of interest. Dr.
   Dafna Gladman has received Grant funding from Amgen, Abbvie, Celgene,
   Eli Lilly, Novartis, UCB, and Pfizer. She likewise received speaker
   honorarium from these companies, as well as BMS and Janssen. Dr. Gladman
   however declares no conflict of interest regarding this paper.
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NR 27
TC 17
Z9 18
U1 0
U2 6
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0172-8172
EI 1437-160X
J9 RHEUMATOL INT
JI Rheumatol. Int.
PD FEB
PY 2018
VL 38
IS 2
BP 219
EP 227
DI 10.1007/s00296-017-3895-y
PG 9
WC Rheumatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Rheumatology
GA FT1SS
UT WOS:000422917100006
PM 29185085
DA 2025-06-11
ER

PT J
AU Platko, K
   Lebeau, PF
   Nederveen, JP
   Byun, JH
   MacDonald, ME
   Bourgeois, JM
   Tarnopolsky, MA
   Austin, RC
AF Platko, Khrystyna
   Lebeau, Paul F.
   Nederveen, Joshua P.
   Byun, Jae Hyun
   MacDonald, Melissa E.
   Bourgeois, Jacqueline M.
   Tarnopolsky, Mark A.
   Austin, Richard C.
TI A Metabolic Enhancer Protects against Diet-Induced Obesity and Liver
   Steatosis and Corrects a Pro-Atherogenic Serum Profile in Mice
SO NUTRIENTS
LA English
DT Article
DE NASH; NAFLD; PCSK9; ROS ER stress
ID ENDOPLASMIC-RETICULUM STRESS; ALPHA-LIPOIC ACID; INDUCED HEPATIC
   STEATOSIS; FATTY LIVER; VITAMIN-E; NONALCOHOLIC STEATOHEPATITIS;
   OXIDATIVE STRESS; GREEN TEA; PHYSICAL-EXERCISE; DISEASE
AB Objective: Metabolic Syndrome (MetS) affects hundreds of millions of individuals and constitutes a major cause of morbidity and mortality worldwide. Obesity is believed to be at the core of metabolic abnormalities associated with MetS, including dyslipidemia, insulin resistance, fatty liver disease and vascular dysfunction. Although previous studies demonstrate a diverse array of naturally occurring antioxidants that attenuate several manifestations of MetS, little is known about the (i) combined effect of these compounds on hepatic health and (ii) molecular mechanisms responsible for their effect. Methods: We explored the impact of a metabolic enhancer (ME), consisting of 7 naturally occurring antioxidants and mitochondrial enhancing agents, on diet-induced obesity, hepatic steatosis and atherogenic serum profile in mice. Results: Here we show that a diet-based ME supplementation and exercise have similar beneficial effects on adiposity and hepatic steatosis in mice. Mechanistically, ME reduced hepatic ER stress, fibrosis, apoptosis, and inflammation, thereby improving overall liver health. Furthermore, we demonstrated that ME improved HFD-induced pro-atherogenic serum profile in mice, similar to exercise. The protective effects of ME were reduced in proprotein convertase subtilisin/kexin 9 (PCSK9) knock out mice, suggesting that ME exerts it protective effect partly in a PCSK9-dependent manner. Conclusions: Our findings suggest that components of the ME have a positive, protective effect on obesity, hepatic steatosis and cardiovascular risk and that they show similar effects as exercise training.
C1 [Platko, Khrystyna; Lebeau, Paul F.; Byun, Jae Hyun; MacDonald, Melissa E.; Austin, Richard C.] McMaster Univ, Dept Med, Div Nephrol, Hamilton, ON L8N 4A6, Canada.
   [Platko, Khrystyna; Lebeau, Paul F.; Byun, Jae Hyun; MacDonald, Melissa E.; Austin, Richard C.] Res Inst St Joes Hamilton, Hamilton, ON L8N 4A6, Canada.
   [Nederveen, Joshua P.; Tarnopolsky, Mark A.] McMaster Univ Med Ctr MUMC, Fac Hlth Sci, Dept Pediat, Hamilton, ON L8N 3Z5, Canada.
   [Bourgeois, Jacqueline M.] McMaster Univ Med Ctr MUMC, Fac Hlth Sci, Dept Pathol & Mol Med, Hamilton, ON L8N 5Z5, Canada.
   [Tarnopolsky, Mark A.] Exerkine Corp, MUMC, Hamilton, ON L8N 3Z5, Canada.
C3 McMaster University; McMaster University; McMaster University
RP Austin, RC (corresponding author), McMaster Univ, Dept Med, Div Nephrol, Hamilton, ON L8N 4A6, Canada.; Austin, RC (corresponding author), Res Inst St Joes Hamilton, Hamilton, ON L8N 4A6, Canada.; Tarnopolsky, MA (corresponding author), McMaster Univ Med Ctr MUMC, Fac Hlth Sci, Dept Pediat, Hamilton, ON L8N 3Z5, Canada.; Tarnopolsky, MA (corresponding author), Exerkine Corp, MUMC, Hamilton, ON L8N 3Z5, Canada.
EM platkok@gmail.com; paulebeau91@gmail.com; byunjh@mcmaster.ca;
   nedervj@mcmaster.ca; macdome@mcmaster.ca; jmariebourg@icloud.com;
   tarnopol@mcmaster.ca; austinr@mcmaster.ca
OI Byun, Jae Hyun/0000-0002-1231-511X; tarnopolsky,
   mark/0000-0003-0312-3746; Austin, Richard/0000-0003-0127-0865
FU Canadian Institutes of Health Research (CIHR) [173520]; Canadian
   Institutes of Health Research (CIHR) Foundation [143325]; CIHR; Amgen
   Canada; Research Institute of St. Joe's Hamilton
FX RC Austin was supported by Canadian Institutes of Health Research (CIHR)
   Project Grant (173520). MA Tarnopolsky was supported by Canadian
   Institutes of Health Research (CIHR) Foundation Grant (143325) and JP
   Nederveen by a CIHR Postdoctoral Fellowship during the tenure of the
   study but funding for the diet preparation came from Exerkine
   Corporation. Additional financial support from The Research Institute of
   St. Joe's Hamilton and Amgen Canada are acknowledged. R.C.A. is a Career
   Investigator of the Heart and Stroke Foundation of Ontario and holds the
   Amgen Canada Research Chair in the Division of Nephrology at St.
   Joseph's Healthcare Hamilton and McMaster University.
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NR 91
TC 3
Z9 3
U1 1
U2 5
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD MAY 22
PY 2023
VL 15
IS 10
AR 2410
DI 10.3390/nu15102410
PG 17
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA H5SH5
UT WOS:000996554800001
PM 37242292
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Cisneros-Yupanqui, M
   Lante, A
   Mihaylova, D
   Krastanov, AI
   Vílchez-Perales, C
AF Cisneros-Yupanqui, Miluska
   Lante, Anna
   Mihaylova, Dasha
   Krastanov, Albert I.
   Vilchez-Perales, Carlos
TI Impact of consumption of cooked red and blackChenopodium
   quinoaWilld. over blood lipids, oxidative stress, and blood glucose
   levels in hypertension-induced rats
SO CEREAL CHEMISTRY
LA English
DT Article
DE antioxidant activity; blood lipids; Chenopodium quinoaWilld; glucose
   sugar levels; hypertension; oxidative stress
ID SEEDS CHENOPODIUM-QUINOA; ANTIOXIDANT ACTIVITIES; METABOLIC SYNDROME;
   PHENOLIC-COMPOUNDS; FATTY-ACID; RESVERATROL; PEPTIDES; WILLD.; FOOD;
   PARAMETERS
AB Background and objectives Hypertension is associated with the overproduction of free radicals, generating oxidative stress, which could contribute to the lipid peroxidation, altering the blood lipid levels, and to the development of diseases such as diabetes. The aim of this work was to evaluate the bioactivity of cooked red and black quinoa over blood lipids, oxidative stress, and glucose levels in hypertension-induced rats by the supply of the drug N (omega)-nitro-L-arginine methyl ester (L-NAME). Findings The consumption of red quinoa increased significantly (p < .05) the levels of high-density lipoprotein (HDL). In addition, the quinoa consumption, regardless of the variety, not only increased the activity of antioxidant enzymes (superoxide dismutase and catalase), but also reduced blood glucose levels. The total phenolic compounds and total flavonoid content were higher in red than in black quinoa, while this latter obtained better values for the total antioxidant activity. Conclusions The presence of bioactive compounds in quinoa could be responsible for its capacity to improve the HDL levels, the in vivo antioxidant activity, and the levels of fasting blood glucose in hypertension-induced rats. Significance and novelty Findings from this study could promote the consumption of quinoa, which seems to be a good source in the development of functional foods, in order to take advantages of its bioactivities.
C1 [Cisneros-Yupanqui, Miluska; Vilchez-Perales, Carlos] Univ Nacl Agr Molina UNALM, Dept Nutr, La Molina, Peru.
   [Cisneros-Yupanqui, Miluska; Lante, Anna] Univ Padua, Dept Agron Food Nat Resources Anim & Environm DAF, Agripolis, Italy.
   [Mihaylova, Dasha; Krastanov, Albert I.] Univ Food Technol, Dept Biotechnol, Plovdiv, Bulgaria.
C3 University of Padua; University of Food Technology - Bulgaria
RP Cisneros-Yupanqui, M (corresponding author), Via Univ 16, Legnaro, Italy.
EM mialecisneros@gmail.com
RI Krastanov, Albert/JAC-5626-2023; Mihaylova, Dasha/L-8364-2016
OI CISNEROS YUPANQUI, MILUSKA ALEXANDRA/0000-0001-5516-4473; LANTE,
   ANNA/0000-0003-4709-9311
FU Consejo Nacional de Ciencia y Tecnologia (CONCYTEC)
   [183-2015-CONCYTEC-CIENCIACTIVA]
FX Consejo Nacional de Ciencia y Tecnologia (CONCYTEC), Grant/Award Number:
   No 183-2015-CONCYTEC-CIENCIACTIVA
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NR 54
TC 13
Z9 14
U1 1
U2 23
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0009-0352
EI 1943-3638
J9 CEREAL CHEM
JI Cereal Chem.
PD NOV
PY 2020
VL 97
IS 6
BP 1254
EP 1262
DI 10.1002/cche.10351
EA OCT 2020
PG 9
WC Chemistry, Applied; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Food Science & Technology
GA OL5AJ
UT WOS:000577781000001
OA Green Published
DA 2025-06-11
ER

PT J
AU Piao, L
   Dorotea, D
   Jiang, S
   Koh, EH
   Oh, GT
   Ha, H
AF Piao, Lingjuan
   Dorotea, Debra
   Jiang, Songling
   Koh, Eun Hee
   Oh, Goo Taeg
   Ha, Hunjoo
TI Impaired Peroxisomal Fitness in Obese Mice, a Vicious Cycle Exacerbating
   Adipocyte Dysfunction via Oxidative Stress
SO ANTIOXIDANTS & REDOX SIGNALING
LA English
DT Article
DE obesity; peroxisome; white adipose tissue; catalase; PPAR alpha;
   fenofibrate
ID ADIPOSE-TISSUE; HYDROGEN-PEROXIDE; LIPID-METABOLISM; WHITE ADIPOCYTE;
   PPAR-ALPHA; C-ABL; FENOFIBRATE; STEATOHEPATITIS; DEFICIENCY; EXPRESSION
AB Aims: Peroxisome is a critical organelle for fatty acid oxidation (FAO) and metabolism of reactive oxygen species (ROS). Increased oxidative stress in adipose tissue contributes to the development of insulin resistance and metabolic syndrome in obesity. This study aimed to investigate the role of peroxisomal fitness in maintaining adipocyte function, which has been under-rated in the obesity research area. Results: Reduced peroxisomal gene expressions in white adipose tissue (WAT) of obese mice suggested a close correlation between peroxisomes and obesity. Peroxisomal biogenesis factor 5 siRNA increased cellular ROS and inflammatory mediators in 3T3-L1 adipocytes. On the contrary, hydrogen peroxide or tumor necrosis factor-alpha treatment significantly decreased biogenesis- and function-related peroxisomal proteins, suggesting a positive feedback loop of ROS/inflammation and peroxisomal dysfunction. Correspondingly, catalase (a major peroxisomal antioxidant)-knockout mice fed with high-fat diet (HFD) exhibited suppressed peroxisomal proteins along with increased oxidative stress and accelerated obesity. In response to fenofibrate (a peroxisomal proliferator) treatment, WAT of HFD-fed wild-type mice showed not only increases in peroxisomal biogenesis and FAO but also attenuated features of adipocyte dysfunction and obesity. However, these results were not observed in peroxisome proliferator-activated receptor-alpha null obese mice. Innovation: Impaired peroxisomal fitness enhanced oxidative stress and inflammation in adipocytes, which exacerbates obesity. Conclusion: Adipose tissue peroxisomal homeostasis plays an important role in attenuating the features of obesity, and it can be a potential therapeutic target of obesity.
C1 [Piao, Lingjuan; Dorotea, Debra; Jiang, Songling; Ha, Hunjoo] Ewha Womans Univ, Grad Sch Pharmaceut Sci, Coll Pharm, 52 Ewhayeodae Gil, Seoul 03760, South Korea.
   [Piao, Lingjuan; Koh, Eun Hee] Univ Ulsan, Coll Med, Asan Inst Life Sci, Seoul, South Korea.
   [Koh, Eun Hee] Univ Ulsan, Coll Med, Dept Internal Med, Seoul, South Korea.
   [Oh, Goo Taeg] Ewha Womans Univ, Dept Life Sci, Seoul, South Korea.
C3 Ewha Womans University; University of Ulsan; University of Ulsan; Ewha
   Womans University
RP Ha, H (corresponding author), Ewha Womans Univ, Grad Sch Pharmaceut Sci, Coll Pharm, 52 Ewhayeodae Gil, Seoul 03760, South Korea.
EM hha@ewha.ac.kr
RI Oh, Goo/AAQ-9995-2021
OI Dorotea, Debra/0000-0002-5302-0617
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NR 41
TC 12
Z9 12
U1 0
U2 21
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1523-0864
EI 1557-7716
J9 ANTIOXID REDOX SIGN
JI Antioxid. Redox Signal.
PD DEC 20
PY 2019
VL 31
IS 18
BP 1339
EP 1351
DI 10.1089/ars.2018.7614
PG 13
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA JN1AP
UT WOS:000496636100002
PM 31530170
OA Green Published
DA 2025-06-11
ER

PT J
AU Jeyapal, S
   Kona, SR
   Mullapudi, SV
   Putcha, UK
   Gurumurthy, P
   Ibrahim, A
AF Jeyapal, Sugeedha
   Kona, Suryam Reddy
   Mullapudi, Surekha Venkata
   Putcha, Uday Kumar
   Gurumurthy, Puvaneswari
   Ibrahim, Ahamed
TI Substitution of linoleic acid with α-linolenic acid or long chain n-3
   polyunsaturated fatty acid prevents Western diet induced nonalcoholic
   steatohepatitis
SO SCIENTIFIC REPORTS
LA English
DT Article
ID INDUCED HEPATIC STEATOSIS; LIVER-DISEASE; METABOLIC SYNDROME;
   DOCOSAHEXAENOIC ACID; OXIDATIVE STRESS; GENE-EXPRESSION; PPAR-ALPHA;
   PREVALENCE; INSULIN; NAFLD
AB Imbalance in the n-6 polyunsaturated fatty acids (PUFA) and n-3 PUFA in the Western diet may increase the risk of nonalcoholic fatty liver disease (NAFLD). This study investigates the impact of substitution of linoleic acid with alpha-linolenic acid (ALA) or long chain (LC) n-3 PUFA and hence decreasing n-6:n-3 fatty acid ratio on high fat, high fructose (HFHF) diet induced nonalcoholic steatohepatitis (NASH). Male Sprague-Dawley rats were divided into four groups and fed control diet, HFHF diet (n-6:n-3 ratio of 200), HFHF diet with ALA (n-6:n-3 ratio of 2) or HFHF diet with LC n-3 PUFA (n-6:n-3 ratio of 5) for 24 weeks. Rats fed HFHF diet with n-6:n-3 ratio of 200 resulted in hepatic steatosis, induced glucose intolerance, insulin resistance and oxidative stress accompanied by increase in markers of inflammation, plasma lipids and aminotransferase levels. Histopathological examination of liver further confirmed the establishment of NASH. ALA and LC n-3 PUFA supplementation prevented hepatic steatosis and dyslipidemia by inhibiting lipogenesis and increasing insulin sensitivity. Furthermore, n-3 PUFA supplementation attenuated hepatic oxidative stress by restoring antioxidant status, decreased inflammation and preserved hepatic architecture. These finding suggest that decreasing n-6:n-3 ratio prevented HFHF induced NASH by attenuating oxidative stress and inflammation.
C1 [Jeyapal, Sugeedha; Kona, Suryam Reddy; Gurumurthy, Puvaneswari; Ibrahim, Ahamed] Natl Inst Nutr, Dept Lipid Chem, Hyderabad, India.
   [Mullapudi, Surekha Venkata; Putcha, Uday Kumar] Natl Inst Nutr, Dept Pathol, Hyderabad, India.
C3 Indian Council of Medical Research (ICMR); ICMR - National Institute of
   Nutrition (NIN); Indian Council of Medical Research (ICMR); ICMR -
   National Institute of Nutrition (NIN)
RP Ibrahim, A (corresponding author), Natl Inst Nutr, Dept Lipid Chem, Hyderabad, India.
EM ahamed65@yahoo.co.in
FU Indian Council of Medical Research, Government of India
   [5/4/3-7/TF/2011/NCD-II]; Indian Council of Medical Research, Government
   of India
FX This work was supported by Grants in aid (5/4/3-7/TF/2011/NCD-II) from
   Indian Council of Medical Research, Government of India to AI. JS was
   supported by a fellowship from Indian Council of Medical Research,
   Government of India.
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TC 49
Z9 58
U1 0
U2 11
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD JUL 19
PY 2018
VL 8
AR 10953
DI 10.1038/s41598-018-29222-y
PG 14
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA GN5LY
UT WOS:000439102400009
PM 30026586
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Kontush, A
   de Faria, EC
   Chantepie, S
   Chapman, MJ
AF Kontush, A
   de Faria, EC
   Chantepie, S
   Chapman, MJ
TI A normotriglyceridemic, low HDL-cholesterol phenotype is characterised
   by elevated oxidative stress and HDL particles with attenuated
   antioxidative activity
SO ATHEROSCLEROSIS
LA English
DT Article
DE HDL particle heterogeneity; atherosclerosis; isoprostanes; lipid
   hydroperoxides
ID HIGH-DENSITY-LIPOPROTEIN; APOLIPOPROTEIN-A-I; ESTER TRANSFER PROTEIN;
   LIPID-PEROXIDATION; METABOLIC SYNDROME; PLASMA LDL; APOA-I; DEFICIENCY;
   EFFLUX; F-2-ISOPROSTANES
AB Objective: Low levels of high density lipoprotein-cholesterol (HDL-C) are highly prevalent in subjects presenting premature atherosclerosis. It is indeterminate as to whether high cardiovascular risk in low HDL-C subjects occurs concomitantly with elevated oxidative stress and/or with biologically dysfunctional HDL particles.
   Methods and results: Systemic oxidative stress (as plasma 8-isoprostanes) was 2.3-fold elevated (p < 0.05) in normocholesterolemic, normotriglyceridemic, normoglycernic low HDL-C subjects (plasma HDL-C, <40 mg/dL; n = 8) as compared to nonnolipidemic controls (n = 15). HDL subfractions (HDL2b, 2a, 3a, 3b and 3c) isolated by density gradient ultracentrifugation from low HDL-C subjects displayed significantly lower (-21 to -43%, p < 0.05) specific antioxidative activity (sAA; capacity to protect LDL from oxidation on a unit particle mass or on a particle number basis) as compared to controls. Altered chemical composition (core triglyceride enrichment, cholesteryl ester depletion) paralleled antioxidative dysfunction of HDL subfractions. Plasma 8-isoprostane levels negatively correlated with sAA of HDL subfractions and positively correlated with the total cholesterol/HDL-C ratio, which was significantly elevated in the low HDL-C phenotype.
   Conclusions: Low HDL-C subjects display elevated oxidative stress and possess HDL particle subspecies with attenuated intrinsic antioxidative activity which is intimately related to their altered chemical composition. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
C1 Hop Pitie, INSERM, Natl Inst Hlth & Med Res, Dyslipoproteinemia & Atherosclerosis Res Unit,U55, F-75651 Paris, France.
   Campinas Univ Hosp, Sch Med, Campinas, Brazil.
C3 Assistance Publique Hopitaux Paris (APHP); Hopital Universitaire
   Pitie-Salpetriere - APHP; Institut National de la Sante et de la
   Recherche Medicale (Inserm); Sorbonne Universite
RP Hop Pitie, INSERM, Natl Inst Hlth & Med Res, Dyslipoproteinemia & Atherosclerosis Res Unit,U55, Pavillon Benjamin Delessert,83 Blvd Hop, F-75651 Paris, France.
EM kontush@chups.jussieu.fr
RI Kontush, Anatol/J-2198-2016; chapman, john/Y-2742-2019
OI Kontush, Anatol/0000-0002-9008-7335; Cotta de Faria,
   Eliana/0000-0002-5208-1274; CHANTEPIE-LABORDE,
   Sandrine/0000-0003-1652-432X
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NR 42
TC 108
Z9 115
U1 0
U2 3
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0021-9150
EI 1879-1484
J9 ATHEROSCLEROSIS
JI Atherosclerosis
PD OCT
PY 2005
VL 182
IS 2
BP 277
EP 285
DI 10.1016/j.atherosclerosis.2005.03.001
PG 9
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 976TM
UT WOS:000232756300009
PM 16159600
DA 2025-06-11
ER

PT J
AU Lobbes, H
   Dalle, C
   Pereira, B
   Ruivard, M
   Mazur, A
   Gladine, C
AF Lobbes, Herve
   Dalle, Celine
   Pereira, Bruno
   Ruivard, Marc
   Mazur, Andrzej
   Gladine, Cecile
TI Eicosanoids and Oxylipin Signature in Hereditary Hemochromatosis
   Patients Are Similar to Dysmetabolic Iron Overload Syndrome Patients but
   Are Impacted by Dietary Iron Absorption
SO ANNALS OF NUTRITION AND METABOLISM
LA English
DT Article
DE Oxylipin; Oxidative stress; Iron meal challenge; Hereditary
   hemochromatosis; Dysmetabolic iron overload syndrome
ID METABOLIC SYNDROME; OXIDATIVE STRESS; LINOLEIC-ACID; ACTIVATION;
   QUANTIFICATION; PREVALENCE; EXPRESSION; PRODUCTS; THERAPY; LIVER
AB Introduction: Oxylipins are mediators of oxidative stress. To characterize the underlying inflammatory processes and phenotype effect of iron metabolism disorders, we investigated the oxylipin profile in hereditary hemochromatosis (HH) and dysmetabolic iron overload syndrome (DIOS) patients. Methods: An LC-MS/MS-based method was performed to quantify plasma oxylipins in 20 HH and 20 DIOS patients in fasting conditions and 3 h after an iron-rich meal in HH patients. Results: Principal component analysis showed no separation between HH and DIOS, suggesting that the clinical phenotype has no direct impact on oxylipin metabolism. 20-HETE was higher in DIOS and correlated with hypertension (p = 0.03). Different oxylipin signatures were observed in HH before and after the iron-rich meal. Discriminant oxylipins include epoxy fatty acids derived from docosahexaenoic acid and arachidonic acid as well as 13-HODE and 9-HODE. Mediation analysis found no major contribution of dietary iron absorption for 16/22 oxylipins significantly affected by the meal. Discussion: The oxylipin profiles of HH and DIOS seemed similar except for 20-HETE, possibly reflecting different hypertension prevalence between the two groups. Oxylipins were significantly affected by the iron-rich meal, but the specific contribution of iron was not clear. Although iron may contribute to oxidative stress and inflammation in HH and DIOS, this does not seem to directly affect oxylipin metabolism.
C1 [Lobbes, Herve; Ruivard, Marc] Hop Estaing, Ctr Hosp Univ Clermont Ferrand, Medecine Interne, 1 Pl Lucie & Raymond Aubrac, Clermont Ferrand, France.
   [Lobbes, Herve; Ruivard, Marc] Univ Clermont Auvergne, Inst Pascal, Ctr Natl Rech Sci, UMR 6602, Clermont Ferrand, France.
   [Dalle, Celine; Mazur, Andrzej; Gladine, Cecile] Inst Natl Rech Agr alimentat & Environm INRAE, Unite Nutr Humaine, UMR 1019, Paris, France.
   [Pereira, Bruno] Ctr Hosp Univ Clermont Ferrand, Unite Biostat, Direct Rech Clin & Innovat, Clermont Ferrand, France.
C3 Universite Clermont Auvergne (UCA); CHU Clermont Ferrand; Universite
   Clermont Auvergne (UCA); Centre National de la Recherche Scientifique
   (CNRS); CNRS - Institute for Engineering & Systems Sciences (INSIS);
   INRAE; Universite Clermont Auvergne (UCA); CHU Clermont Ferrand
RP Gladine, C (corresponding author), Inst Natl Rech Agr alimentat & Environm INRAE, Unite Nutr Humaine, UMR 1019, Paris, France.
EM cecile.gladine@inrae.fr
RI Mazur, Andre/AAG-9751-2020; Lobbes, Hervé/AAK-7695-2020
FU Clermont-Ferrand University Hospital [AOI-2016-RUIVARD]; Company DRT
FX The research was supported by Clermont-Ferrand University Hospital
   (Grant No. AOI-2016-RUIVARD). The company DRT provided a grant to
   support the research (payment to Clermont-Ferrand University Hospital).
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NR 46
TC 0
Z9 0
U1 0
U2 4
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0250-6807
EI 1421-9697
J9 ANN NUTR METAB
JI Ann. Nutr. Metab.
PD JUN
PY 2024
VL 80
IS 3
BP 117
EP 127
DI 10.1159/000536657
PG 11
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA TU3M1
UT WOS:001243732800004
PM 38354712
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Cortés-Espinar, AJ
   Ibarz-Blanch, N
   Soliz-Rueda, JR
   Calvo, E
   Bravo, FI
   Mulero, M
   Avila-Román, J
AF Cortes-Espinar, Antonio J.
   Ibarz-Blanch, Nestor
   Soliz-Rueda, Jorge R.
   Calvo, Enrique
   Bravo, Francisca Isabel
   Mulero, Miquel
   Avila-Roman, Javier
TI Abrupt Photoperiod Changes Differentially Modulate Hepatic Antioxidant
   Response in Healthy and Obese Rats: Effects of Grape Seed
   Proanthocyanidin Extract (GSPE)
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE oxidative stress; phenolic compounds; obesity; GSPE; chronodisruption;
   liver; zeitgeber; chronotherapy
ID OXIDATIVE STRESS; CAFETERIA DIET; CIRCADIAN CLOCK; METABOLIC SYNDROME;
   LIPID-METABOLISM; GENE-EXPRESSION; NRF2 PATHWAY; BODY-WEIGHT;
   INFLAMMATION; LIGHT
AB Disruptions of the light/dark cycle and unhealthy diets can promote misalignment of biological rhythms and metabolic alterations, ultimately leading to an oxidative stress condition. Grape seed proanthocyanidin extract (GSPE), which possesses antioxidant properties, has demonstrated its beneficial effects in metabolic-associated diseases and its potential role in modulating circadian disruptions. Therefore, this study aimed to assess the impact of GSPE administration on the liver oxidant system of healthy and diet-induced obese rats undergoing a sudden photoperiod shift. To this end, forty-eight photoperiod-sensitive Fischer 344/IcoCrl rats were fed either a standard (STD) or a cafeteria diet (CAF) for 6 weeks. A week before euthanizing, rats were abruptly transferred from a standard photoperiod of 12 h of light/day (L12) to either a short (6 h light/day, L6) or a long photoperiod (18 h light/day, L18) while receiving a daily oral dose of vehicle (VH) or GSPE (25 mg/kg). Alterations in body weight gain, serum and liver biochemical parameters, antioxidant gene and protein expression, and antioxidant metabolites were observed. Interestingly, GSPE partially ameliorated these effects by reducing the oxidative stress status in L6 through an increase in GPx1 expression and in hepatic antioxidant metabolites and in L18 by increasing the NRF2/KEAP1/ARE pathway, thereby showing potential in the treatment of circadian-related disorders by increasing the hepatic antioxidant response in a photoperiod-dependent manner.
C1 [Cortes-Espinar, Antonio J.; Ibarz-Blanch, Nestor; Soliz-Rueda, Jorge R.; Calvo, Enrique; Bravo, Francisca Isabel; Mulero, Miquel] Univ Rovira i Virgili, Dept Biochem & Biotechnol, Nutrigen Res Grp, Tarragona 43007, Spain.
   [Cortes-Espinar, Antonio J.; Ibarz-Blanch, Nestor; Soliz-Rueda, Jorge R.; Calvo, Enrique; Bravo, Francisca Isabel; Mulero, Miquel] Inst Invest Sanit Pere Virgili, Nutrigen Res Grp, Tarragona 43007, Spain.
   [Avila-Roman, Javier] Univ Seville, Dept Pharmacol, Mol & Appl Pharmacol Grp FARMOLAP, Seville 41012, Spain.
C3 Universitat Rovira i Virgili; Universitat Rovira i Virgili; Institut
   d'Investigacio Sanitaria Pere Virgili (IISPV); University of Sevilla
RP Mulero, M (corresponding author), Univ Rovira i Virgili, Dept Biochem & Biotechnol, Nutrigen Res Grp, Tarragona 43007, Spain.; Mulero, M (corresponding author), Inst Invest Sanit Pere Virgili, Nutrigen Res Grp, Tarragona 43007, Spain.; Avila-Román, J (corresponding author), Univ Seville, Dept Pharmacol, Mol & Appl Pharmacol Grp FARMOLAP, Seville 41012, Spain.
EM antoniojesus.cortes@estudiants.urv.cat; nestor.ibarz@urv.cat;
   jorgericardo.soliz@urv.cat; enrique.calvo@urv.cat;
   franciscaisabel.bravo@urv.cat; miquel.mulero@urv.cat; javieravila@us.es
RI Bravo, Francisca/L-4409-2019; Ibarz Blanch, Néstor/HZK-7802-2023;
   Avila-Roman, Javier/B-5337-2017; Mulero, Miquel/L-4672-2014; Calvo,
   Enrique/K-8680-2014; Soliz Rueda, Jorge Ricardo/HKE-0954-2023
OI Bravo, Francisca Isabel/0000-0002-6468-3088; Mulero,
   Miquel/0000-0003-2545-2065; Calvo, Enrique/0000-0002-2468-0931; Cortes
   Espinar, Antonio Jesus/0000-0003-4058-4672; Avila-Roman, Francisco
   Javier/0000-0001-9766-8178; Ibarz-Blanch, Nestor/0000-0003-2920-8502;
   Soliz Rueda, Jorge Ricardo/0000-0001-7307-8202
FU Spanish Ministry of Science and Innovation MCIN/AEI; ERDF "A way of
   making Europe" [PID2021-128813OB-I00]; Universitat Rovira i
   Virgili-Martii Franques [2019PMF-PIPF-74]
FX This project was funded by the Spanish Ministry of Science and
   Innovation MCIN/AEI/10.13039/501100011033/; ERDF "A way of making
   Europe" (grant number: PID2021-128813OB-I00).A.J.C.-E. was the recipient
   of a grant for the hiring of predoctoral research staff from Universitat
   Rovira i Virgili-Martii Franques (2019PMF-PIPF-74). F.I.B. and M.M. are
   Serra Hunter Fellows.
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NR 96
TC 0
Z9 0
U1 2
U2 3
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD DEC
PY 2023
VL 24
IS 23
AR 17057
DI 10.3390/ijms242317057
PG 23
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA AN3E2
UT WOS:001119097600001
PM 38069379
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Espinosa-Zurutuza, M
   González-Villalva, A
   Albarrán-Alonso, JC
   Colín-Barenque, L
   Bizarro-Nevares, P
   Rojas-Lemus, M
   López-Valdéz, N
   Fortoul, TI
AF Espinosa-Zurutuza, Maribel
   Gonzalez-Villalva, Adriana
   Carlos Albarran-Alonso, Juan
   Colin-Barenque, Laura
   Bizarro-Nevares, Patricia
   Rojas-Lemus, Marcela
   Lopez-Valdez, Nelly
   Fortoul, Teresa I.
TI Oxidative Stress as a Mechanism Involved in Kidney Damage After
   Subchronic Exposure to Vanadium Inhalation and Oral Sweetened Beverages
   in a Mouse Model
SO INTERNATIONAL JOURNAL OF TOXICOLOGY
LA English
DT Article
DE kidney; vanadium; inhalation; sweetened beverages; oxidative stress
ID GLYCATION END-PRODUCTS; RENAL-FUNCTION; POLLUTION; DISEASE; METALS; AIR;
   ASSOCIATIONS; DECREASE; RECEPTOR; HEALTH
AB Kidney diseases have notably increased in the last few years. This is partially explained by the increase in metabolic syndrome, diabetes, and systemic blood hypertension. However, there is a segment of the population that has neither of the previous risk factors, yet suffers kidney damage. Exposure to atmospheric pollutants has been suggested as a possible risk factor. Air-suspended particles carry on their surface a variety of fuel combustion-related residues such as metals, and vanadium is one of these. Vanadium might produce oxidative stress resulting in the damage of some organs such as the kidney. Additionally, in countries like Mexico, the ingestion of sweetened beverages is a major issue; whether these beverages alone are responsible for direct kidney damage or whether their ingestion promotes the progression of an existing renal damage generates controversy. In this study, we report the combined effect of vanadium inhalation and sweetened beverages ingestion in a mouse model. Forty CD-1 male mice were distributed in 4 groups: control, vanadium inhalation, 30% sucrose in drinking water, and vanadium inhalation plus sucrose 30% in drinking water. Our results support that vanadium inhalation and the ingestion of 30% sucrose induce functional and histological kidney damage and an increase in oxidative stress biomarkers, which were higher in the combined effect of vanadium plus 30% sucrose. The results also support that the ingestion of 30% sucrose alone without hyperglycemia also produces kidney damage.
C1 [Espinosa-Zurutuza, Maribel; Gonzalez-Villalva, Adriana; Carlos Albarran-Alonso, Juan; Bizarro-Nevares, Patricia; Rojas-Lemus, Marcela; Lopez-Valdez, Nelly; Fortoul, Teresa I.] Univ Nacl Autonoma Mexico, Fac Med, Dept Biol Celular & Tisular, Mexico City 04510, DF, Mexico.
   [Colin-Barenque, Laura] FES Iztacala, Lab Neuromorfol, Mexico City, DF, Mexico.
C3 Universidad Nacional Autonoma de Mexico
RP González-Villalva, A; Fortoul, TI (corresponding author), Univ Nacl Autonoma Mexico, Fac Med, Dept Biol Celular & Tisular, Mexico City 04510, DF, Mexico.
EM fortoul@unam.mx
RI Fortoul, Teresa/AAW-3936-2020
OI Fortoul, Teresa/0000-0002-3507-1365; GONZALEZ-VILLALVA,
   ADRIANA/0000-0002-5693-107X
FU  [PAPIIT-UNAM IN-211315]
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: This work
   was partially supported by grants PAPIIT-UNAM IN-211315.
CR [Anonymous], 2012, TOXICOLOGICAL PROFIL
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NR 43
TC 22
Z9 23
U1 0
U2 13
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1091-5818
EI 1092-874X
J9 INT J TOXICOL
JI Int. J. Toxicol.
PD JAN-FEB
PY 2018
VL 37
IS 1
BP 45
EP 52
DI 10.1177/1091581817745504
PG 8
WC Pharmacology & Pharmacy; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Toxicology
GA FU3GR
UT WOS:000423739300005
PM 29254395
OA Bronze
DA 2025-06-11
ER

PT J
AU Monserrat-Mesquida, M
   Quetglas-Llabrés, M
   Bouzas, C
   García, S
   Mateos, D
   Gómez, C
   Gámez, JM
   Poulsen, HE
   Tur, JA
   Sureda, A
AF Monserrat-Mesquida, Margalida
   Quetglas-Llabres, Magdalena
   Bouzas, Cristina
   Garcia, Silvia
   Mateos, David
   Gomez, Cristina
   Gamez, Jose M.
   Poulsen, Henrik E.
   Tur, Josep A.
   Sureda, Antoni
TI Effects of 2-Year Nutritional and Lifestyle Intervention on Oxidative
   and Inflammatory Statuses in Individuals of 55 Years of Age and over at
   High Cardiovascular Risk
SO ANTIOXIDANTS
LA English
DT Article
DE obesity; cardiovascular disease; oxidative stress; inflammation;
   biomarkers
ID PHYSICAL-ACTIVITY QUESTIONNAIRE; METABOLIC SYNDROME; WEIGHT-LOSS;
   MEDITERRANEAN DIET; ADIPOSE-TISSUE; FOLLOW-UP; XANTHINE-OXIDASE; OBESE
   MEN; STRESS; METAANALYSIS
AB Obesity and overweight are disorders with high impact on the morbidity and mortality of chronic diseases, such as type 2 diabetes mellitus (T2DM) and cardiovascular diseases (CVD). We aim to assess the effects of 2-year nutritional and lifestyle intervention on oxidative and inflammatory status in individuals of 55 years of age and over at high CVD risk. Participants (n = 100 individuals of 55 years of age and over living in the Balearic Islands, Spain) were randomized into control and intervention group. Anthropometric and haematological parameters, blood pressure and physical activity were measured before and after the intervention. Oxidative and inflammatory biomarkers in plasma, urine, peripheral blood mononuclear cells (PBMCs) and neutrophils were determined. A higher reduction in abdominal obesity, blood pressure and triglycerides levels was observed after a 2-year intervention. An improvement of oxidative stress and proinflammatory status was demonstrated with a significant reduction in myeloperoxidase, xanthine oxidase, malondialdehyde and monocyte chemoattractant protein-1 (MCP1) levels, and an increase in polyphenols in plasma was observed. A decrease in reactive oxygen species production in PBMCs and neutrophils levels after zymosan and lipopolysaccharide activation was found in the intervention group with respect to the control group. The intervention with hypocaloric Mediterranean Diet and customized physical activity improves oxidative stress and proinflammatory status and could contribute to decreasing the CVD risk.
C1 [Monserrat-Mesquida, Margalida; Quetglas-Llabres, Magdalena; Bouzas, Cristina; Garcia, Silvia; Mateos, David; Gomez, Cristina; Gamez, Jose M.; Tur, Josep A.; Sureda, Antoni] Univ Balearic Isl IUNICS, Res Grp Community Nutr & Oxidat Stress, Palma De Mallorca 07122, Spain.
   [Monserrat-Mesquida, Margalida; Quetglas-Llabres, Magdalena; Bouzas, Cristina; Garcia, Silvia; Mateos, David; Gomez, Cristina; Gamez, Jose M.; Tur, Josep A.; Sureda, Antoni] Hlth Res Inst Balearic Isl IdISBa, Palma De Mallorca 07120, Spain.
   [Monserrat-Mesquida, Margalida; Bouzas, Cristina; Gamez, Jose M.; Tur, Josep A.; Sureda, Antoni] Inst Salud Carlos III ISCIII, CIBER Fisiopatol Obesidad & Nutr CIBEROBN, Madrid 28029, Spain.
   [Gomez, Cristina] Univ Hosp Son Espases, Clin Anal Serv, Palma De Mallorca 07198, Spain.
   [Gamez, Jose M.] Univ Hosp Son Llatzer, Cardiol Serv, Palma De Mallorca 07010, Spain.
   [Poulsen, Henrik E.] Copenhagen Univ Hosp Bispebjerg & Frederiksberg, Dept Endocrinol, DK-2400 Copenhagen, Denmark.
   [Poulsen, Henrik E.] Univ Copenhagen, Dept Clin Med, DK-2200 Copenhagen, Denmark.
   [Poulsen, Henrik E.] Copenhagen Univ Hosp North Zealand, Dept Cardiol, DK-3400 Hillerod, Denmark.
C3 Institut Investigacio Sanitaria Illes Balears (IdISBa); CIBER - Centro
   de Investigacion Biomedica en Red; CIBEROBN; Hospital Universitari Son
   Espases; Hospital Universitari Son Llatzer; University of Copenhagen;
   Bispebjerg Hospital; University of Copenhagen
RP Tur, JA (corresponding author), Univ Balearic Isl IUNICS, Res Grp Community Nutr & Oxidat Stress, Palma De Mallorca 07122, Spain.; Tur, JA (corresponding author), Hlth Res Inst Balearic Isl IdISBa, Palma De Mallorca 07120, Spain.; Tur, JA (corresponding author), Inst Salud Carlos III ISCIII, CIBER Fisiopatol Obesidad & Nutr CIBEROBN, Madrid 28029, Spain.
EM margalida.monserrat@uib.es; m.quetglas@uib.es; cristina.bouzas@uib.es;
   silvia.garcia@uib.es; davidfrom13@gmail.com; cristina.gomez@ssib.es;
   jmgamez@hsll.es; henrik.enghusen.poulsen.01@regionh.dk; pep.tur@uib.es;
   antoni.sureda@uib.es
RI Mesquida, Margalida/AAB-4773-2019; Tur, Josep/AAE-5748-2020; Bouzas,
   Cristina/AAE-2069-2019; Quetglas Llabrés, Maria/AAA-4412-2019; Mateos,
   David/N-7366-2018; Sureda, Antoni/N-9588-2019; Tur, Josep/F-5576-2014
OI , Antoni/0000-0001-8656-6838; Tur, Josep/0000-0002-6940-0761; GOMEZ
   COBO, CRISTINA/0000-0002-9776-4730; Monserrat Mesquida,
   Margalida/0000-0002-8856-135X; Bouzas Velasco,
   Cristina/0000-0002-1407-8461
FU Instituto de Salud Carlos III through the Fondo de Investigacion para la
   Salud [CIBEROBN CB12/03/30038, PI20/00456]; IDISBA; Directorate General
   of R+D of the Balearic Islands Government
FX Instituto de Salud Carlos III through the Fondo de Investigacion para la
   Salud (CIBEROBN CB12/03/30038 and project PI20/00456), which are
   cofounded by the European Regional Development Fund. IDISBA Grants
   (FOLIUM, PRIMUS, SYNERGIA, and LIBERI). M.Q.-L.L. was funded by the
   IDISBA grant. C.B. was funded by a post-doctoral grant from the
   Directorate General of R+D of the Balearic Islands Government. The
   funding sponsors had no role in the design of the study; in the
   collection, analyses or interpretation of the data; in the writing of
   the manuscript; or in the decision to publish the results.
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NR 81
TC 7
Z9 7
U1 0
U2 8
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD JUL
PY 2022
VL 11
IS 7
AR 1326
DI 10.3390/antiox11071326
PG 16
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA 3H9SU
UT WOS:000832369000001
PM 35883817
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Qiao, Y
   Sun, J
   Ding, YY
   Le, GW
   Shi, YH
AF Qiao, Yi
   Sun, Jin
   Ding, Yinyi
   Le, Guowei
   Shi, Yonghui
TI Alterations of the gut microbiota in high-fat diet mice is strongly
   linked to oxidative stress
SO APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
LA English
DT Article
DE Gut microbiota; Oxidative stress; High-fat diet; Lipoic acid
ID INTESTINAL MICROBIOTA; NITRIC-OXIDE; CAPACITY; OLIGOSACCHARIDES;
   LACTOBACILLI; SUPEROXIDE; METABOLISM; EXPRESSION; PROTECTION; MODULATE
AB Alterations of the gut microbiota induced by diet exert a strong influence on the development of metabolic syndrome. In this study, we prove the hypothesis that the long-term high-fat diet (HFD) may influence gut microbiota directly and/or indirectly by changing the redox state. Lipoic acid (LA), as a universal antioxidant, was used to improve the redox state. Reactive oxygen species (ROS), total antioxidant capacity (T-AOC), and malondialdehyde (MDA) were analyzed to profile oxidative stress states. PCR-denaturing gradient gel electrophoresis (DGGE) was used to describe gut flora structures, while plate count was employed for the quantitative analysis of Escherichia coli, lactobacilli, and enterococcus. The influence of redox state on the vitality of gut-derived bacteria was measured in vitro. ROS and MDA, which significantly decreased in LA mice compared with HFD mice, showed a strong positive association with E. coli and enterococcus (P < 0.05) and a negative association with lactobacilli (P < 0.05). Increased T-AOC in LA mice showed a high positive association with lactobacilli (P < 0.05) and a negative correlation with E. coli and enterococcus. These correlations implied that the dietary effects on the gut microbiota were conferred, at least in part, through an effect on oxidative stress. This study provides evidence that modulation of the redox state by an antioxidant has the potential to improve gut microbiota, which has relevance for metabolic health.
C1 [Qiao, Yi; Sun, Jin; Ding, Yinyi; Le, Guowei; Shi, Yonghui] Jiangnan Univ, State Key Lab Food Sci & Technol, Wuxi, Peoples R China.
   [Qiao, Yi; Sun, Jin; Le, Guowei; Shi, Yonghui] Jiangnan Univ, Sch Food Sci & Technol, Food Nutr & Funct Factors Res Ctr, Wuxi, Peoples R China.
C3 Jiangnan University; Jiangnan University
RP Shi, YH (corresponding author), Jiangnan Univ, Sch Food Sci & Technol, Food Nutr & Funct Factors Res Ctr, Wuxi, Peoples R China.
EM yhshi@jiangnan.edu.cn
RI Ding, Yin-Yi/JTU-3995-2023; SHI, YH/HLG-1159-2023
FU National Natural Science Foundation of China [30671525]; 12th Five-Year
   Plan for Science and Technology Development [2012BAD33B05]; Fundamental
   Research Funds for the Central Universities [JUSRP111A32]
FX This work was supported by a grant from the National Natural Science
   Foundation of China (No. 30671525), the 12th Five-Year Plan for Science
   and Technology Development (No. 2012BAD33B05) and the Fundamental
   Research Funds for the Central Universities (No. JUSRP111A32).
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NR 49
TC 167
Z9 185
U1 1
U2 150
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0175-7598
EI 1432-0614
J9 APPL MICROBIOL BIOT
JI Appl. Microbiol. Biotechnol.
PD FEB
PY 2013
VL 97
IS 4
BP 1689
EP 1697
DI 10.1007/s00253-012-4323-6
PG 9
WC Biotechnology & Applied Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology
GA 082QM
UT WOS:000314407300026
PM 22948953
DA 2025-06-11
ER

PT J
AU Orlando, P
   Sabbatinelli, J
   Silvestri, S
   Marcheggiani, F
   Cirilli, I
   Dludla, PV
   Molardi, A
   Nicolini, F
   Tiano, L
AF Orlando, Patrick
   Sabbatinelli, Jacopo
   Silvestri, Sonia
   Marcheggiani, Fabio
   Cirilli, Ilenia
   Dludla, Phiwayinkosi Vusi
   Molardi, Alberto
   Nicolini, Francesco
   Tiano, Luca
TI Ubiquinol supplementation in elderly patients undergoing aortic valve
   replacement: biochemical and clinical aspects
SO AGING-US
LA English
DT Article
DE ubiquinol; cardiac surgery; ageing; oxidative stress
ID ARTERY-BYPASS GRAFT; C-REACTIVE PROTEIN; ALPHA-LIPOIC ACID; COENZYME
   Q(10); CARDIAC-SURGERY; OXIDATIVE STRESS; DOUBLE-BLIND; TISSUE
   CONCENTRATIONS; METABOLIC SYNDROME; HEART-FAILURE
AB Epidemiological data show a rise in the mean age of patients affected by heart disease undergoing cardiac surgery. Senescent myocardium reduces the tolerance to ischemic stress and there are indications about age associated deficit in post-operative cardiac performance. Coenzyme Q10 (CoQ10), and more specifically its reduced form ubiquinol (QH), improve several conditions related to bioenergetic deficit or increased exposure to oxidative stress. This trial (Eudra-CT 2009-015826-13) evaluated the clinical and biochemical effects of ubiquinol in 50 elderly patients affected by severe aortic stenosis undergoing aortic valve replacement and randomized to either placebo or 400 mg/day ubiquinol from 7 days before to 5 days after surgery. Plasma and cardiac tissue CoQ10 levels and oxidative status, circulating troponin I, CK-MB (primary endpoints), IL-6 and S100B were assessed. Moreover, main cardiac adverse effects, NYHA class, contractility and myocardial hypertrophy (secondary endpoints) were evaluated during a 6-month follow-up visit. Ubiquinol treatment counteracted the post-operative plasma CoQ10 decline (p<0.0001) and oxidation (p=0.038) and curbed the post-operative increase in troponin I (QH, 1.90 [1.47-2.48] ng/dL; placebo, 4.03 [2.45-6.63] ng/dL; p=0.007) related to cardiac surgery. Moreover, ubiquinol prevented the adverse outcomes that might have been associated with defective left ventricular ejection fraction recovery in elderly patients.
C1 [Orlando, Patrick; Silvestri, Sonia; Marcheggiani, Fabio; Cirilli, Ilenia; Dludla, Phiwayinkosi Vusi; Tiano, Luca] Univ Politecn Marche, Dept Life & Environm Sci, Via Brecce Bianche, I-60100 Ancona, Italy.
   [Sabbatinelli, Jacopo] Univ Politecn Marche, Dept Clin & Mol Sci, DISCLIMO, I-60100 Ancona, Italy.
   [Dludla, Phiwayinkosi Vusi] South African Med Res Council, Biomed Res & Innovat Platform, ZA-7505 Tygerberg, South Africa.
   [Molardi, Alberto; Nicolini, Francesco] Parma Univ Hosp, Cardiac Surg Dept, I-43126 Parma, Italy.
C3 Marche Polytechnic University; Marche Polytechnic University; South
   African Medical Research Council; University of Parma; University
   Hospital of Parma
RP Tiano, L (corresponding author), Univ Politecn Marche, Dept Life & Environm Sci, Via Brecce Bianche, I-60100 Ancona, Italy.
EM l.tiano@staff.univpm.it
RI Orlando, Patrick/LSJ-0851-2024; Tiano, Luca/ABC-2341-2020; Sabbatinelli,
   Jacopo/U-1851-2018
OI Sabbatinelli, Jacopo/0000-0001-9947-6778; Orlando,
   Patrick/0000-0002-4203-9611
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NR 76
TC 8
Z9 9
U1 0
U2 9
PU IMPACT JOURNALS LLC
PI ORCHARD PARK
PA 6666 E QUAKER ST, STE 1, ORCHARD PARK, NY 14127 USA
SN 1945-4589
J9 AGING-US
JI Aging-US
PD AUG 15
PY 2020
VL 12
IS 15
BP 15514
EP 15531
PG 18
WC Cell Biology; Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Geriatrics & Gerontology
GA NM1ZH
UT WOS:000567901800004
PM 32741773
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU da Silva, BP
   Toledo, RCL
   Mishima, MDV
   Moreira, MED
   Vasconcelos, CM
   Pereira, CER
   Favarato, LSC
   Costa, NMB
   Martino, HSD
AF da Silva, Barbara Pereira
   Lopes Toledo, Renata Celi
   Villas Mishima, Marcella Duarte
   de Castro Moreira, Maria Eliza
   Vasconcelos, Christiane Mileib
   Real Pereira, Carlos Eduardo
   Campos Favarato, Lukiya Silva
   Brunoro Costa, Neuza Maria
   Duarte Martino, Hercia Stampini
TI Effects of chia (Salvia hispanica L.) on oxidative stress and
   inflammation in ovariectomized adult female Wistar rats
SO FOOD & FUNCTION
LA English
DT Article
ID HIGH-FAT DIET; METABOLIC SYNDROME; SEED; SUPPLEMENTATION; LIVER; ACIDS;
   N-3; EXPRESSION; STEATOSIS; IMPROVES
AB The present study investigated the influence of chia consumption on inflammation, oxidative stress, and lipid profiles in adult female ovariectomized rats fed a high-fat diet. Forty ovariectomized and 40 intact (SHAM) rats were allocated into 8 groups (n = 10), and each rat received one of the following four diets: standard diet (ST); standard diet + chia (STC); high-fat diet (HF); and high-fat diet + chia (HFC) for 126 days. Biochemical parameters and biomarkers of lipid peroxidation, inflammation, and oxidative stress were evaluated. The mRNA expression levels of PPAR-alpha, NF kappa B, TNF-alpha and Zn-SOD1 were analyzed, as well as those of TNF-alpha and IL-1 beta. Chia intake increased HDL cholesterol (HDL-c) and reduced LDL cholesterol (LDL-c) levels. Plasma catalase activity was elevated in the STC group. Concentrations of TBARS were higher in all groups fed HF. PPAR-alpha mRNA expression was elevated, and levels of NF kappa B mRNA expression were reduced in the STC group. mRNA expression and protein levels of TNF-alpha were lower in rats fed the standard diet. Protein levels of IL-1 beta were reduced in rats fed the standard diet, and the high fat diet with chia. In general, ovariectomy did not influence the inflammatory and oxidative stress parameters. Chia intake improved antioxidant activity by increasing SOD expression, PPAR-alpha expression, catalase activity, and HDL-c levels. In addition, chia consumption decreased the concentrations of the inflammatory markers IL-1 beta and LDL-c.
C1 [da Silva, Barbara Pereira; Lopes Toledo, Renata Celi; Villas Mishima, Marcella Duarte; de Castro Moreira, Maria Eliza; Duarte Martino, Hercia Stampini] Univ Fed Vicosa, Dept Nutr & Hlth, Ave Purdue S-N,Campus Univ, BR-36570900 Vicosa, MG, Brazil.
   [Vasconcelos, Christiane Mileib] Vila Velha Univ, Plant Biotechnol Program, Ave Comissario Jose Dantas Melo 21, BR-29102623 Vila Velha, ES, Brazil.
   [Real Pereira, Carlos Eduardo] Microvet, Special Vet Microbiol, Ave Joaquim Lopes Faria 730, BR-36570000 Vicosa, MG, Brazil.
   [Campos Favarato, Lukiya Silva] Univ Fed Vicosa, Dept Vet Med, Ave Purdue S-N,Campus Univ, BR-36570900 Vicosa, MG, Brazil.
   [Brunoro Costa, Neuza Maria] Univ Fed Espirito Santo, Dept Nutr, Alto Univ S-N, BR-29500000 Alegre, ES, Brazil.
   [de Castro Moreira, Maria Eliza] Fac Dinam Vale Piranga FADIP, Rua G 205, BR-35430302 Ponte Nova, MG, Brazil.
C3 Universidade Federal de Vicosa; Centro Universitario Vila Velha;
   Universidade Federal de Vicosa; Universidade Federal do Espirito Santo
RP da Silva, BP (corresponding author), Univ Fed Vicosa, Dept Nutr & Hlth, Ave Purdue S-N,Campus Univ, BR-36570900 Vicosa, MG, Brazil.
EM hercia72@gmail.com
RI Silva, Barbara/NKO-7601-2025; Vasconcelos, Christiane/AAP-1848-2020;
   Pereira, Carlos/ISV-1307-2023
OI da Silva, Barbara Pereira/0000-0003-1096-456X
FU Foundation for Research Support of Minas Gerais (FAPEMIG, Brazil)
FX The authors would like to thank the Foundation for Research Support of
   Minas Gerais (FAPEMIG, Brazil) for the research financial support; the
   Coordination for the Improvement of Higher Education Personnel (CAPES,
   Brazil), and the National Counsel of Technological and Scientific
   Development (CNPq, Brazil).
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NR 47
TC 17
Z9 21
U1 0
U2 9
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PD JUL 1
PY 2019
VL 10
IS 7
BP 4036
EP 4045
DI 10.1039/c9fo00862d
PG 10
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA IK6GK
UT WOS:000476683600018
PM 31219482
DA 2025-06-11
ER

PT J
AU Di Domenico, K
   Wiltgen, D
   Nickel, FJ
   Magalhaes, JA
   Moraes, RS
   Spritzer, PM
AF Di Domenico, Kristhiane
   Wiltgen, Denusa
   Nickel, Fabian J.
   Magalhaes, Jose Antonio
   Moraes, Ruy Silveira
   Spritzer, Poli Mara
TI Cardiac autonomic modulation in polycystic ovary syndrome: does the
   phenotype matter?
SO FERTILITY AND STERILITY
LA English
DT Article
DE Heart rate variability; autonomic modulation; PCOS phenotype
ID HEART-RATE-VARIABILITY; CARDIOVASCULAR-DISEASE; INSULIN-RESISTANCE;
   METABOLIC-SYNDROME; ANDROGEN EXCESS; WOMEN; RISK; MORTALITY; SEX;
   DYSLIPIDEMIA
AB Objective: To assess whether heart rate variability (HRV) at rest and during sympathetic stimulation is disturbed in patients with different polycystic ovary syndrome (PCOS) phenotypes in comparison to healthy controls.
   Design: Cross-sectional study.
   Setting: University hospital.
   Patient(s): Thirty women with classic, anovulatory PCOS, 16 women with ovulatory PCOS, and 23 age-paired women with regular and proven ovulatory cycles.
   Intervention(s): Anthropometric and hormonal evaluation and analysis of HRV (time and frequency domain HRV indices) at rest and after a mental stress test.
   Main Outcome Measure(s): Difference between HRV components during rest and stress.
   Result(s): Mean age was 22.80 +/- 5.80 years in patients with classic PCOS, 19.81 +/- 6.43 years in ovulatory PCOS, and 22.65 +/- 5.89 years in controls. During mental stress, patients with classic PCOS showed lower HRV response when compared with the control group, even after adjustment for body mass index (BMI) and age. When patients with classic and ovulatory PCOS were considered together, total T levels were inversely associated with the low frequency component, low frequency/high frequency ratio, and the difference between high frequency response at rest and after the stress test.
   Conclusion(s): Young patients with the classic PCOS phenotype have an impaired autonomic modulation in response to sympathetic stimulation that is typical of considerably older women, or of advanced age. (Fertil Steril (R) 2013; 99: 286-92. (C) 2013 by American Society for Reproductive Medicine.)
C1 [Di Domenico, Kristhiane; Wiltgen, Denusa; Nickel, Fabian J.; Spritzer, Poli Mara] Hosp Clin Porto Alegre, Div Endocrinol, Gynecol Endocrinol Unit, BR-90035003 Porto Alegre, RS, Brazil.
   [Magalhaes, Jose Antonio] Hosp Clin Porto Alegre, Div Gynecol & Obstet, BR-90035003 Porto Alegre, RS, Brazil.
   [Moraes, Ruy Silveira] Hosp Clin Porto Alegre, Div Cardiol, BR-90035003 Porto Alegre, RS, Brazil.
   [Spritzer, Poli Mara] Univ Fed Rio Grande do Sul, Mol Endocrinol Lab, Dept Physiol, Porto Alegre, RS, Brazil.
   [Spritzer, Poli Mara] Conselho Nacl Desenvolvimento Cient & Tecnol CNPq, Natl Inst Hormones & Womens Hlth, Porto Alegre, RS, Brazil.
C3 Hospital de Clinicas de Porto Alegre; Hospital de Clinicas de Porto
   Alegre; Hospital de Clinicas de Porto Alegre; Universidade Federal do
   Rio Grande do Sul
RP Spritzer, PM (corresponding author), Hosp Clin Porto Alegre, Div Endocrinol, Gynecol Endocrinol Unit, Rua Ramiro Barcelos 2350, BR-90035003 Porto Alegre, RS, Brazil.
EM spritzer@ufrgs.br
RI Spritzer, Poli/A-3357-2019; Moraes, Ruy/W-5089-2019
OI Spritzer, Poli Mara/0000-0002-5204-107X; Silveira Moraes,
   Ruy/0000-0001-6802-7128
FU Conselho Nacional de Desenvolvimento Cientifico e Tecnologico [CNPq INCT
   573747/2008-3]; Fundo de Apoio a Pesquisa do Hospital de Clinicas de
   Porto Alegre, Brazil [FIPE-HCPA 100317]
FX Supported by grants from Conselho Nacional de Desenvolvimento Cientifico
   e Tecnologico (CNPq INCT 573747/2008-3) and Fundo de Apoio a Pesquisa do
   Hospital de Clinicas de Porto Alegre (FIPE-HCPA 100317), Brazil.
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NR 49
TC 41
Z9 44
U1 0
U2 5
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0015-0282
EI 1556-5653
J9 FERTIL STERIL
JI Fertil. Steril.
PD JAN
PY 2013
VL 99
IS 1
BP 286
EP 292
DI 10.1016/j.fertnstert.2012.08.049
PG 7
WC Obstetrics & Gynecology; Reproductive Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology; Reproductive Biology
GA 064AX
UT WOS:000313044400048
PM 23025880
OA Bronze
DA 2025-06-11
ER

PT J
AU Manning, PJ
   Sutherland, WHF
   Walker, RJ
   Williams, SM
   de Jong, SA
   Berry, EA
AF Manning, Patrick J.
   Sutherland, Wayne H. F.
   Walker, Robert J.
   Williams, Sheila M.
   de Jong, Sylvia A.
   Berry, Elizabeth A.
TI The effect of rosiglitazone on oxidative stress and insulin resistance
   in overweight individuals
SO DIABETES RESEARCH AND CLINICAL PRACTICE
LA English
DT Article
DE insulin resistance; rosiglitazone; obesity
ID IMPAIRED GLUCOSE-TOLERANCE; METABOLIC SYNDROME; INFLAMMATORY MARKERS;
   3T3-L1 ADIPOCYTES; NONDIABETIC PATIENTS; VITAMIN-E; PIOGLITAZONE;
   ADIPONECTIN; SENSITIVITY; ACTIVATION
AB Objective: The purpose of this study was to examine the chronic effect of rosiglitazone on oxidative stress, inflammatory markers and hepatic risk factors for type 2 diabetes in overweight individuals. In addition we examined the effect of rosiglitazone on post-glucose challenge levels of glucose and insulin.
   Research design and methods: Forty overweight individuals (BMI > 27 kg/m(2)) were randomized in a double blind fashion to receive 6 months treatment with either rosiglitazone 4 mg/day or placebo. Primary endpoints were markers of oxidative stress (plasma peroxides), inflammatory markers (IL-6, TNF-alpha and CRP) and postprandial glucose metabolism (glucose and insulin). Secondary endpoints were changes in insulin resistance as measured by HOMA, first and second phase insulin secretion, adiponectin and effects on lipid and hepatic parameters.
   Results: Plasma peroxides (-15%) decreased significantly during 6 months in the group that received rosiglitazone compared with placebo. Fasting plasma insulin concentrations decreased by 24% and HOMA increased by 35% in those receiving rosiglitazone. Plasma IL-6 (-25%), CRP (-55%) and GGT (-25%) concentrations declined significantly in the rosiglitazone group. Rosiglitazone increased plasma adiponectin by 81%. Treatment with rosiglitazone also resulted in significantly reduced first phase (-33%) and second phase (-20%) insulin release.
   Conclusions: In overweight non-diabetic people rosiglitazone reduces oxidative stress and improves insulin sensitivity. Rosiglitazone also improves first and second phase insulin secretion and reduces markers of inflammation and GGT. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
C1 [Manning, Patrick J.; Sutherland, Wayne H. F.; Walker, Robert J.; de Jong, Sylvia A.; Berry, Elizabeth A.] Univ Otago, Dept Med & Surg Sci, Dunedin Sch Med, Dunedin, New Zealand.
   [Williams, Sheila M.] Univ Otago, Dept Prevent & Social Med, Dunedin Sch Med, Dunedin, New Zealand.
C3 University of Otago; University of Otago
RP Manning, PJ (corresponding author), Univ Otago, Dept Med & Surg Sci, Dunedin Sch Med, Private Bag, Dunedin, New Zealand.
EM patrickmanning@healthotago.co.nz
RI Williams, Sheila/L-4028-2019; Walker, Robert/B-1498-2010
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NR 39
TC 17
Z9 19
U1 0
U2 2
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0168-8227
J9 DIABETES RES CLIN PR
JI Diabetes Res. Clin. Pract.
PD AUG
PY 2008
VL 81
IS 2
BP 209
EP 215
DI 10.1016/j.diabres.2008.04.015
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 349OE
UT WOS:000259289400013
PM 18541328
DA 2025-06-11
ER

PT J
AU Rolland, B
   Deguil, J
   Jardri, R
   Cottencin, O
   Thomas, P
   Bordet, R
AF Rolland, Benjamin
   Deguil, Julie
   Jardri, Renaud
   Cottencin, Olivier
   Thomas, Pierre
   Bordet, Regis
TI Therapeutic Prospects of PPARs in Psychiatric Disorders: A Comprehensive
   Review
SO CURRENT DRUG TARGETS
LA English
DT Review
DE Peroxisome proliferator-activated receptors; biological psychiatry;
   schizophrenia; mood disorders; personality disorders; post-traumatic
   stress disorders
ID PROLIFERATOR-ACTIVATED RECEPTORS; POSTTRAUMATIC-STRESS-DISORDER; MAJOR
   DEPRESSIVE DISORDER; FORCED SWIMMING TEST; OXIDATIVE STRESS; D
   PERSONALITY; BIPOLAR DISORDER; METABOLIC SYNDROME; RAT-BRAIN;
   INFLAMMATORY CYTOKINES
AB Peroxisome Proliferator-Activated Receptors (PPARs) are a family of nuclear receptors whose activation modulates the gene expression that underlies both the glucid-lipid and the inflammation pathways. While many PPARs agonists have been used for years as medication for metabolic disorders, an increasing attention is being currently dedicated to these drugs for inflammation-related pathologies.
   Within the psychiatric field, it has recently appeared that inflammatory processes are highly suspected in the pathophysiology of several important disorders, such as schizophrenia and mood disorders. By their anti-inflammatory properties, PPARs might have a disease-modifying action that could help in improving the outcome of patients. Furthermore, recent data suggest that PPARs could also modulate the expression of some neurotransmission factors. Therefore, PPARs may directly modify the information processing, and have a potential symptomatic action on several psychiatric disorders. At last, PPARs action of metabolic regulation could have a role on corrective or even preventive strategies against the metabolic adverse events that are commonly observed with some current psychiatric medications, notably antipsychotics.
   This triple potential action profile of PPARs modulators is investigated in this article, successively for schizophrenia spectrum disorders and mood disorders. Theoretical involvements of PPARs are also discussed for the treatment of Post-Traumatic Stress Disorder and Personality Disorders. At the time of the emerging concept of psychoneuroimmunology, PPARs open original therapeutic prospects for the psychiatric research.
C1 [Rolland, Benjamin; Deguil, Julie; Bordet, Regis] Univ Lille Nord France, CHU Lille, EA 1046, Dept Pharmacol, F-59045 Lille, France.
   [Rolland, Benjamin; Jardri, Renaud; Cottencin, Olivier; Thomas, Pierre] CHU Lille, Dept Psychiat & Addict Med, F-59037 Lille, France.
   [Rolland, Benjamin; Jardri, Renaud; Cottencin, Olivier; Thomas, Pierre] Univ Lille 2, LNFP, EA4559, Dept Neurosci, F-59045 Lille, France.
C3 Universite de Lille; CHU Lille; Universite de Lille; CHU Lille;
   Universite de Lille
RP Bordet, R (corresponding author), Univ Lille 2, Fac Med, Pole Rech, Dept Pharmacol Med, 1 Pl Verdun, F-59045 Lille, France.
EM regis.bordet@univ-lille2.fr
RI ROLLAND, Benjamin/H-6625-2019; Jardri, Renaud/J-9202-2012; ROLLAND,
   Benjamin/E-7374-2013; /I-4024-2015
OI Jardri, Renaud/0000-0003-4596-1502; ROLLAND,
   Benjamin/0000-0002-8666-3635; /0000-0003-3663-1405
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NR 106
TC 28
Z9 30
U1 0
U2 13
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1389-4501
EI 1873-5592
J9 CURR DRUG TARGETS
JI Curr. Drug Targets
PD JUN
PY 2013
VL 14
IS 7
BP 724
EP 732
DI 10.2174/1389450111314070002
PG 9
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 150IQ
UT WOS:000319384200002
PM 23531161
DA 2025-06-11
ER

PT J
AU Lee, MJ
   Jung, CH
   Hwang, JY
   Shin, MS
   Yu, JH
   Lee, WJ
   Park, JY
AF Lee, Min Jung
   Jung, Chang Hee
   Hwang, Jenie Yoonoo
   Shin, Mi Seon
   Yu, Ji Hee
   Lee, Woo Je
   Park, Joong-Yeol
TI Association Between Serum Ceruloplasmin Levels and Arterial Stiffness in
   Korean Men with Type 2 Diabetes Mellitus
SO DIABETES TECHNOLOGY & THERAPEUTICS
LA English
DT Article
ID PULSE-WAVE VELOCITY; LOW-DENSITY-LIPOPROTEIN; CORONARY-HEART-DISEASE;
   OXIDATIVE STRESS; CARDIOVASCULAR-DISEASE; MYOCARDIAL-INFARCTION;
   METABOLIC SYNDROME; AORTIC STIFFNESS; RISK; INFLAMMATION
AB Background: Increased oxidative stress contributes to the development of arterial stiffness. Arterial stiffness, as measured by brachial-ankle pulse wave velocity (baPWV), has been known to be correlated with oxidative stress. Serum ceruloplasmin (CP), a copper-carrying protein, may indicate the overall level of oxidative stress in the body. The present study investigated whether serum CP levels are associated with baPWV in Korean men with type 2 diabetes mellitus (DM).
   Subjects and Methods: Serum CP levels and conventional risk factors were measured in 760 Korean men with type 2 DM. Arterial stiffness was assessed by baPWV obtained with an automatic device (model VP-1000; Colin, Komaki, Japan).
   Results: Correlation analysis indicated a significant positive association between serum CP and baPWV (r=0.109, P=0.003). Age-adjusted baPWV increased gradually according to serum CP quartiles (Q1, 1,500.3 +/- 18.4 cm/s; Q2, 1,511.6 +/- 17.8 cm/s; Q3, 1,551.8 +/- 17.9 cm/s; Q4, 1,622.1 +/- 17.8 cm/s; P for trend <0.001). Multivariate linear regression analysis showed that serum CP was independently associated with baPWV in various models.
   Conclusions: A positive relationship was identified between CP and baPWV in adult male subjects with type 2 DM, which was independent of conventional cardiovascular risk factors. Further studies are needed to confirm whether CP contributes to the pathogenesis of increased arterial stiffness in subjects with type 2 DM.
C1 [Lee, Min Jung; Jung, Chang Hee; Hwang, Jenie Yoonoo; Shin, Mi Seon; Yu, Ji Hee; Lee, Woo Je; Park, Joong-Yeol] Univ Ulsan, Coll Med, Dept Internal Med, Seoul 138736, South Korea.
C3 University of Ulsan
RP Park, JY (corresponding author), Univ Ulsan, Coll Med, Dept Internal Med, Seoul 138736, South Korea.
EM jypark@amc.seoul.kr
RI Kim, Tae-Hee/AAN-9079-2021; Jung, Chang/AAU-7897-2020
OI Yu, Ji Hee/0000-0003-1907-2859
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NR 44
TC 7
Z9 8
U1 0
U2 2
PU MARY ANN LIEBERT INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1520-9156
J9 DIABETES TECHNOL THE
JI Diabetes Technol. Ther.
PD DEC
PY 2012
VL 14
IS 12
BP 1091
EP 1097
DI 10.1089/dia.2012.0177
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 054MW
UT WOS:000312348900004
PM 23050733
DA 2025-06-11
ER

PT J
AU Emeny, RT
   Zierer, A
   Lacruz, ME
   Baumert, J
   Herder, C
   Gornitzka, G
   Koenig, W
   Thorand, B
   Ladwig, KH
AF Emeny, Rebecca T.
   Zierer, Astrid
   Lacruz, Maria Elena
   Baumert, Jens
   Herder, Christian
   Gornitzka, Gabriele
   Koenig, Wolfgang
   Thorand, Barbara
   Ladwig, Karl-Heinz
CA KORA Investigators
TI Job Strain-Associated Inflammatory Burden and Long-Term Risk of Coronary
   Events: Findings from the MONICA/KORA Augsburg Case-Cohort Study
SO PSYCHOSOMATIC MEDICINE
LA English
DT Article
DE work stress; job strain; inflammation; psychoneuroimmunology; coronary
   disease; prospective
ID C-REACTIVE PROTEIN; TYPE-2 DIABETES-MELLITUS; ISCHEMIC-HEART-DISEASE;
   MIDDLE-AGED MEN; WHITEHALL-II; DECISION LATITUDE;
   CARDIOVASCULAR-DISEASE; MYOCARDIAL-INFARCTION; WORK STRESS;
   GENERAL-POPULATION
AB Background: We examined the association between job strain and coronary heart disease (CHD) and investigated the role of markers of inflammation and endothelial dysfunction as possible mediators of job strain-associated CHD risk. Methods: The sample (n = 1027) included employed participants (35-64 years old, 68% male) from the population-based MONICA/KORA (Monitoring of Trends and Determinants in Cardiovascular Disease/Kooperative Gesundheitsforschung in der Region Augsburg) studies. At baseline Karasek's Job Strain Index was assessed during standardized personal interviews, and nine biological markers were measured (1984-1995). Participants were followed (average, 12 years) to assess incident events (sudden cardiac death or fatal and nonfatal myocardial infarction). In this case-cohort design, the final sample contained 114 cases and 913 noncases. Results: Baseline distributions of cardiometabolic risk factors were significantly different between cases and noncases, with no detectable job strain-specific differences. However, cases with high job strain had higher monocyte chemoattractant protein-1, interleukin (IL)-8, and IL-18 compared with noncases with high job strain. High-sensitivity C-reactive protein, IL-6, and soluble intercellular adhesion molecule-1 were increased in cases versus noncases, regardless of work stress. Job strain was associated with incident coronary events in Cox proportional hazards models adjusted for age, sex, and survey (hazard ratio = 2.57, 95% confidence interval = 1.09-6.07) and after adjustment for CHD risk factors (2.35, 1.003-5.49). Adjustment for monocyte chemoattractant protein-1 or IL-8 increased this risk estimate by 14.5% or 9.4%, respectively, whereas adjustment for C-reactive protein and soluble intercellular adhesion molecule-1 led to decreased hazard ratios (-9.9% and -5.5%, respectively). Conclusions: Job strain increased CHD risk in healthy workers; the associated inflammatory burden may contribute to stress-related coronary pathogenesis.
C1 [Emeny, Rebecca T.; Zierer, Astrid; Lacruz, Maria Elena; Baumert, Jens; Thorand, Barbara; Ladwig, Karl-Heinz] Helmholtz Zentrum Muenchen, German Res Ctr Environm Hlth, Inst Epidemiol 2, D-85764 Neuherberg, Germany.
   [Herder, Christian; Gornitzka, Gabriele] Univ Dusseldorf, Leibniz Ctr Diabet Res, German Diabet Ctr, Inst Clin Diabetol, Dusseldorf, Germany.
   [Koenig, Wolfgang] Univ Ulm, Med Ctr, Dept Internal Med Cardiol 2, D-89069 Ulm, Germany.
   [Ladwig, Karl-Heinz] Tech Univ Munich, Klinikum Rechts Isar, Dept Psychosomat Med & Psychotherapy, D-80290 Munich, Germany.
C3 Helmholtz Association; Helmholtz-Center Munich - German Research Center
   for Environmental Health; Leibniz Association; Deutsches
   Diabetes-Zentrum (DDZ); Heinrich Heine University Dusseldorf; Ulm
   University; Technical University of Munich
RP Ladwig, KH (corresponding author), Helmholtz Zentrum Muenchen, German Res Ctr Environm Hlth, Inst Epidemiol 2, Ingolstaedter Landstr 1, D-85764 Neuherberg, Germany.
EM ladwig@helmholtz-muenchen.de
RI Emeny, Rebecca/I-1100-2014; Koenig, Wolfgang/JCF-0788-2023; Thorand,
   Barbara/B-5349-2014; Ladwig, Karl-Heinz/B-5351-2014; Lacruz,
   Maria/KHV-7908-2024
OI Koenig, Wolfgang/0000-0002-2064-9603; Lacruz, Maria
   Elena/0000-0003-2036-3039
FU Helmholtz Zentrum Munchen, German Research Center for Environmental
   Health, Neuherberg, Germany; German Federal Ministry of Education,
   Science, Research, and Technology; State of Bavaria; German Research
   Foundation [TH-784/2-1, TH-784/2-2]; European Foundation for the Study
   of Diabetes; Federal Ministry of Health (Berlin, Germany); Ministry of
   Innovation, Science, Research, and Technology of the state North
   Rhine-Westphalia (Dusseldorf, Germany); University of Ulm, Germany;
   German Diabetes Center
FX The MONICA/KORA Augsburg studies were initiated and financed by the
   GSF-National Research Center for Environment and Health, Neuherberg,
   Germany (now Helmholtz Zentrum Munchen, German Research Center for
   Environmental Health) and the German Federal Ministry of Education,
   Science, Research, and Technology and by the State of Bavaria.
   Additional support was provided by the German Research Foundation
   (TH-784/2-1 and TH-784/2-2), the European Foundation for the Study of
   Diabetes, the Federal Ministry of Health (Berlin, Germany), and the
   Ministry of Innovation, Science, Research, and Technology of the state
   North Rhine-Westphalia (Dusseldorf, Germany), as well as by additional
   funds provided by the University of Ulm, Germany, and the German
   Diabetes Center. The authors report no conflicts of interest.
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NR 56
TC 29
Z9 33
U1 0
U2 9
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0033-3174
EI 1534-7796
J9 PSYCHOSOM MED
JI Psychosom. Med.
PD APR
PY 2013
VL 75
IS 3
BP 317
EP 325
DI 10.1097/PSY.0b013e3182860d63
PG 9
WC Psychiatry; Psychology; Psychology, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry; Psychology
GA 300MG
UT WOS:000330467400540
PM 23460721
DA 2025-06-11
ER

PT J
AU Wein, S
   Behm, N
   Petersen, RK
   Kristiansen, K
   Wolffram, S
AF Wein, Silvia
   Behm, Norma
   Petersen, Rasmus K.
   Kristiansen, Karsten
   Wolffram, Siegfried
TI Quercetin enhances adiponectin secretion by a PPAR-γ independent
   mechanism
SO EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
LA English
DT Article
DE Flavonoids; Adiponectin; Peroxisome-proliferator-activated-receptor;
   Oxidative stress; Quercetin
ID BETA-CELL FUNCTION; OXIDATIVE STRESS; INSULIN-RESISTANCE; FLAVONOL
   QUERCETIN; LIPID-PEROXIDATION; METABOLIC SYNDROME; FATTY-ACIDS;
   ANTIOXIDANT; BIOAVAILABILITY; SENSITIVITY
AB To study possible insulin sensitizing, anti-inflammatory and anti-oxidative effects of the flavonol quercetin, rats were fed a high-fat diet (19%, w/w) with (HFQ) or without (HF) 0.03% quercetin or a flavonoid-poor low-fat (5%, w/w) maintenance diet (LF) over 4 weeks. Body weight was measured weekly, and plasma concentrations of adiponectin, leptin, insulin, glucose, triacylglycerols, total cholesterol, as well as of markers of inflammation and oxidative stress were measured (12 h fasted) at the end of the feeding period. Adiponectin and peroxisome-proliferator-activated-receptor (PPAR)-gamma mRNA were measured in adipose tissue (WAT) by real-time RT-PCR. PPAR-gamma transactivation was investigated by means of a reporter gene assay. HF feeding resulted in elevated fasted plasma glucose concentrations, while HFQ did not differ from LF feeding. In the HFQ group plasma concentrations and WAT mRNA levels of adiponectin were elevated compared with the HF group, however, PPAR-gamma mRNA concentration in WAT was decreased (HFQvs. HF). Compared to both other groups quercetin feeding significantly reduced oxidative stress, measured by plasma 8-iso-PGF(2 alpha), while body weight gain, body composition and plasma leptin levels were not affected. Neither quercetin nor its metabolites induced PPAR-gamma-mediated transactivation in vitro.
   Adiponectin stimulating effects of quercetin are PPAR-gamma-independent and prevent impairment of insulin sensitivity without affecting body weight and composition. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Wein, Silvia; Behm, Norma; Wolffram, Siegfried] Univ Kiel, Inst Anim Nutr & Physiol, D-24118 Kiel, Germany.
   [Petersen, Rasmus K.; Kristiansen, Karsten] Univ So Denmark, Dept Biochem & Mol Biol, Odense, Denmark.
   [Kristiansen, Karsten] Univ Copenhagen, Dept Biol, Copenhagen, Denmark.
C3 University of Kiel; University of Southern Denmark; University of
   Copenhagen
RP Wein, S (corresponding author), Univ Kiel, Inst Anim Nutr & Physiol, Herrmann Rodewald Str 9, D-24118 Kiel, Germany.
EM wein@aninut.uni-kiel.de
RI Wein, Silvia/I-6375-2013; Kristiansen, Karsten/J-5148-2014
OI Kristiansen, Karsten/0000-0002-6024-0917; Petersen, Rasmus
   Koefoed/0009-0003-6889-4899
FU Danish Council for Strategic Research [2101-01-0065]
FX We are grateful to Wiebke Kuhl and Petra Schulz for excellent technical
   support. Financial support: work in the laboratory of Prof. Kristiansen
   was supported by the Danish Council for Strategic Research (Project No.
   2101-01-0065).
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NR 55
TC 78
Z9 87
U1 0
U2 17
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0928-0987
EI 1879-0720
J9 EUR J PHARM SCI
JI Eur. J. Pharm. Sci.
PD SEP 11
PY 2010
VL 41
IS 1
BP 16
EP 22
DI 10.1016/j.ejps.2010.05.004
PG 7
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 638EN
UT WOS:000280875700003
PM 20580672
DA 2025-06-11
ER

PT J
AU Takahashi, KI
   Chin, K
   Nakamura, H
   Morita, S
   Sumi, K
   Oga, T
   Matsumoto, H
   Niimi, A
   Fukuhara, S
   Yodoi, J
   Mishima, M
AF Takahashi, Ken-Ichi
   Chin, Kazuo
   Nakamura, Hajime
   Morita, Satoshi
   Sumi, Kensuke
   Oga, Toru
   Matsumoto, Hisako
   Niimi, Akio
   Fukuhara, Shunichi
   Yodoi, Junji
   Mishima, Michiaki
TI Plasma thioredoxin, a novel oxidative stress marker, in patients with
   obstructive sleep apnea before and after nasal continuous positive
   airway pressure
SO ANTIOXIDANTS & REDOX SIGNALING
LA English
DT Article
ID C-REACTIVE PROTEIN; ADIPOSE-SPECIFIC PROTEIN; SERUM THIOREDOXIN;
   MYOCARDIAL-INFARCTION; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   RISK-FACTORS; ADIPONECTIN; DISEASE; OBESITY
AB Obstructive sleep apnea (OSA) is associated with increased cardiovascular mortality, and oxidative stress was suggested to play an important role. We hypothesized that the plasma TRX level, a novel oxidative stress marker, is elevated in OSA patients. Plasma TRX and adiponectin levels, which are significantly associated with cardiovascular mortality, were measured in 41 patients with severe OSA before (n = 41) and after (n = 27) nasal continuous positive airway pressure therapy (nCPAP) for 1 month and in 12 subjects without OSA (non-OSA group). The TRX level was significantly higher (p = 0.02) and the adiponectin level was significantly lower (p = 0.02) in the OSA group than in the non-OSA group. After I month of nCPAP (n = 27), the TRX level significantly decreased (p = 0.03), and the adiponectin level significantly increased (p = 0.03). Among the 14 patients with untreated OSA, the TRX and adiponectin levels did not significantly change over a 1-month interval. Among the 53 (41 OSA + 12 non-OSA) subjects, the TRX level was positively correlated with the respiratory disturbance index (p = 0.001) and percentage of time with SaO(2) <90% (p = 0.0002). The adiponectin level, but not the TRX level, was correlated with the BMI (n = 53; p = 0.02). Plasma TRX may be a unique marker for evaluating oxidative stress and monitoring the effectiveness of nCPAP in OSA patients.
C1 [Takahashi, Ken-Ichi; Chin, Kazuo; Sumi, Kensuke; Oga, Toru; Matsumoto, Hisako; Niimi, Akio; Mishima, Michiaki] Kyoto Univ, Grad Sch Med, Dept Resp Med, Sakyo Ku, Kyoto 6068507, Japan.
   [Nakamura, Hajime] Kyoto Univ, Translat Res Ctr, Dept Expt Therapeut, Kyoto 6068507, Japan.
   [Morita, Satoshi; Fukuhara, Shunichi] Kyoto Univ, Grad Sch Med, Dept Epidemiol & Hlth Care Res, Kyoto 6068507, Japan.
   [Yodoi, Junji] Kyoto Univ, Inst Virus Res, Dept Biol Responses, Kyoto 6068507, Japan.
C3 Kyoto University; Kyoto University; Kyoto University; Kyoto University
RP Chin, K (corresponding author), Kyoto Univ, Grad Sch Med, Dept Resp Med, Sakyo Ku, 54 Shogoin Kawahara Cho, Kyoto 6068507, Japan.
EM chink@kuhp.kyoto-u.ac.jp
RI Yodoi, Junji/F-6189-2011
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NR 43
TC 68
Z9 73
U1 0
U2 6
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1523-0864
EI 1557-7716
J9 ANTIOXID REDOX SIGN
JI Antioxid. Redox Signal.
PD APR
PY 2008
VL 10
IS 4
BP 715
EP 726
DI 10.1089/ars.2007.1949
PG 12
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 262VM
UT WOS:000253176100006
PM 18199002
DA 2025-06-11
ER

PT J
AU Cousin, L
AF Cousin, Lakeshia
TI Cardio-oncology disparities: Interplay of psychosocial stress,
   inflammation, and cardiometabolic health among Black breast cancer
   survivors
SO AMERICAN HEART JOURNAL PLUS: CARDIOLOGY RESEARCH AND PRACTICE
LA English
DT Article
DE Health disparities; Women's health; Metabolic syndrome; Cardio-oncology
AB Black breast cancer (BC) survivors have a lower survival rate at every stage of the disease, largely due to a higher BC mortality rate of 41 %, more aggressive forms of BC, cardiovascular comorbidities, and stress related to structural inequities. An underexplored factor is Black women's increased risk for cardiometabolic syndrome (CM), exacerbating cardio-oncology disparities. Many factors associated with increased risk for CM are modifiable through lifestyle behavior interventions and generally fail to improve outcomes among Black women. This lack of efficacy is likely due to the interventions' failure to address the cumulative effects of long-term exposure to psychosocial stressors unique to Black women using cultural frameworks. The protocol design of an 8-week pilot study was presented at the inaugural UF Health Cardio-Oncology Symposium, "Emerging Topics in Cardio-Oncology." Twenty-six selfreported Black BC survivors will be randomized using a two-group parallel random assignment experimental design, and study details are reported on ClinicalTrials.gov (#NCT05473026). Our primary aim is to assess the feasibility and acceptability of a culturally relevant gratitude journaling intervention to manage stress and promote goalsetting techniques. The second aim is to test the preliminary efficacy of the intervention on stress, inflammatory biomarkers (TNF-alpha, IL-6, GDF15, CRP), dispositional gratitude, spiritual well-being, and a culturally relevant framework (Superwoman Schema) to examine stressors unique to Black women. If found to be effective, this clinical trial will provide evidence of a viable nonpharmacological intervention for managing psychosocial stressors, improving CM risk, and reducing cardiooncology disparities.
C1 [Cousin, Lakeshia] Univ Florida, Coll Nursing, Cardiooncol Working Grp, Hlth Canc Ctr,Dept Family Community & Hlth Syst Sc, Gainesville, FL USA.
   [Cousin, Lakeshia] POB 100197, Gainesville, FL 32610 USA.
C3 State University System of Florida; University of Florida
RP Cousin, L (corresponding author), POB 100197, Gainesville, FL 32610 USA.
EM lakeshiacousin@ufl.edu
RI Cousin, Lakeshia/AAU-3863-2020
OI Cousin, Lakeshia/0000-0002-9649-8864
FU University of Florida Claude D. Pepper Older Americans Independence
   Center [P30AG028740]
FX Dr. Lakeshia Cousin's research was supported by the University of
   Florida Claude D. Pepper Older Americans Independence Center [grant
   number P30AG028740] .
CR Allen AM, 2019, ANN NY ACAD SCI, V1457, P104, DOI 10.1111/nyas.14188
   Barber LE, 2021, BREAST CANCER RES, V23, DOI 10.1186/s13058-021-01483-y
   Cousin Lakeshia, 2021, Clin J Oncol Nurs, V25, P36, DOI 10.1188/21.CJON.S1.36-41
   Giaquinto AN, 2022, CA-CANCER J CLIN, V72, P202, DOI 10.3322/caac.21718
   Halbert CH, 2020, HEALTH PSYCHOL, V39, P745, DOI 10.1037/hea0000882
   Kwan ML, 2022, J CLIN ONCOL, V40, P1635, DOI 10.1200/JCO.21.01738
   Meadows RJ, 2020, J PSYCHOSOC ONCOL, V38, P343, DOI 10.1080/07347332.2019.1692988
   Sheppard VB, 2018, J RELIG HEALTH, V57, P1918, DOI 10.1007/s10943-018-0611-5
   Woods-Giscombé CL, 2010, QUAL HEALTH RES, V20, P668, DOI 10.1177/1049732310361892
NR 9
TC 3
Z9 3
U1 0
U2 0
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
EI 2666-6022
J9 AM HEART J PLUS
JI Am. Heart J. Plus-Cardiol. Res. Pract.
PD FEB
PY 2024
VL 38
AR 100366
DI 10.1016/j.ahjo.2024.100366
EA FEB 2024
PG 2
WC Cardiac & Cardiovascular Systems
WE Emerging Sources Citation Index (ESCI)
SC Cardiovascular System & Cardiology
GA KC1Q2
UT WOS:001177673600001
PM 38510748
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Patel, S
   Haider, A
   Alvarez-Guaita, A
   Bidault, G
   Moustafa, JSES
   Guiu-Jurado, E
   Tadross, JA
   Warner, J
   Harrison, J
   Virtue, S
   Scurria, F
   Zvetkova, I
   Blüher, M
   Small, KS
   O'Rahilly, S
   Savage, DB
AF Patel, Satish
   Haider, Afreen
   Alvarez-Guaita, Anna
   Bidault, Guillaume
   Moustafa, Julia Sarah El-Sayed
   Guiu-Jurado, Esther
   Tadross, John A.
   Warner, James
   Harrison, James
   Virtue, Samuel
   Scurria, Fabio
   Zvetkova, Ilona
   Bluher, Matthias
   Small, Kerrin S.
   O'Rahilly, Stephen
   Savage, David B.
TI Combined genetic deletion of GDF15 and FGF21 has modest effects on body
   weight, hepatic steatosis and insulin resistance in high fat fed mice
SO MOLECULAR METABOLISM
LA English
DT Article
DE GDF15; FGF21; Insulin resistance; Obesity
ID GROWTH-FACTOR 21; ENDOPLASMIC-RETICULUM STRESS; DIFFERENTIATION FACTOR
   15; ENERGY-EXPENDITURE; SERUM CONCENTRATIONS; METABOLIC SYNDROME;
   ANTIDIABETIC ACTIONS; TISSUE EXPRESSION; BETA-KLOTHO; OBESITY
AB Objectives: Obesity in humans and mice is associated with elevated levels of two hormones responsive to cellular stress, namely GDF15 and FGF21. Over-expression of each of these is associated with weight loss and beneficial metabolic changes but where they are secreted from and what they are required for physiologically in the context of overfeeding remains unclear.Methods: Here we used tissue selective knockout mouse models and human transcriptomics to determine the source of circulating GDF15 in obesity. We then generated and characterized the metabolic phenotypes of GDF15/FGF21 double knockout mice. Results: Circulating GDF15 and FGF21 are both largely derived from the liver, rather than adipose tissue or skeletal muscle, in obese states. Combined whole body deletion of FGF21 and GDF15 does not result in any additional weight gain in response to high fat feeding but it does result in significantly greater hepatic steatosis and insulin resistance than that seen in GDF15 single knockout mice.Conclusions: Collectively the data suggest that overfeeding activates a stress response in the liver which is the major source of systemic rises in GDF15 and FGF21. These hormones then activate pathways which reduce this metabolic stress.(c) 2022 The Author(s). Published by Elsevier GmbH. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
C1 [Patel, Satish; Haider, Afreen; Alvarez-Guaita, Anna; Bidault, Guillaume; Tadross, John A.; Warner, James; Virtue, Samuel; Scurria, Fabio; Zvetkova, Ilona; O'Rahilly, Stephen; Savage, David B.] Univ Cambridge, Metab Res Labs, Wellcome Trust MRC Inst Metab Sci, Cambridge CB2 0QQ, England.
   [Patel, Satish; Haider, Afreen; O'Rahilly, Stephen; Savage, David B.] Univ Cambridge, MRC Metab Dis Unit, Wellcome MRC Inst Metab Sci, Cambridge, England.
   [Harrison, James] Univ Cambridge, Div Cardiovasc Med, Dept Med, Cambridge, England.
   [Guiu-Jurado, Esther; Bluher, Matthias] Univ Leipzig, Med Dept Endocrinol Nephrol Rheumatol 3, Med Ctr, D-04103 Leipzig, Germany.
   [Bluher, Matthias] Univ Leipzig, Helmholtz Inst Metab Obes & Vasc Res HIMAG, Helmholtz Zentrum Munchen, Leipzig, Germany.
   [Bluher, Matthias] Univ Hosp Leipzig, Leipzig, Germany.
   [Moustafa, Julia Sarah El-Sayed; Small, Kerrin S.] Kings Coll London, Dept Twin Res & Genet Epidemiol, St Thomas Campus, London SE1 7EH, England.
   [Tadross, John A.] Cambridge Univ Hosp NHS Fdn Trust, East Midlands & East England Genom Lab Hub, Cambridge, England.
   [Tadross, John A.] Cambridge Univ Hosp NHS Fdn Trust, Dept Histopathol, Cambridge, England.
C3 University of Cambridge; University of Cambridge; University of
   Cambridge; Leipzig University; Leipzig University; Helmholtz
   Association; Helmholtz-Center Munich - German Research Center for
   Environmental Health; Leipzig University; University of London; King's
   College London; University of Cambridge; University of Cambridge
RP Patel, S; Haider, A; Savage, DB (corresponding author), Univ Cambridge, Metab Res Labs, Wellcome Trust MRC Inst Metab Sci, Cambridge CB2 0QQ, England.; Patel, S; Haider, A; Savage, DB (corresponding author), Univ Cambridge, MRC Metab Dis Unit, Wellcome MRC Inst Metab Sci, Cambridge, England.
EM sp632@medschl.cam.ac.uk; afreen.haider@gmail.com;
   dbs23@medschl.cam.ac.uk
RI O'Rahilly, Stephen/ABF-6509-2020; Polasek, Ozren/B-6002-2011; El-Sayed
   Moustafa, Julia Sarah/JRX-2237-2023; Guiu-Jurado, Esther/D-4706-2018;
   Virtue, SAm/B-7578-2013; Harrison, James/B-8958-2009; Tadross,
   John/E-7513-2012
OI Harrison, James/0000-0003-4960-5062; El-Sayed Moustafa, Julia
   Sarah/0000-0001-6963-6654; Small, Kerrin/0000-0003-4566-0005; Patel,
   Satish/0000-0002-5345-8942; Haider, Afreen/0000-0003-4768-0499; Virtue,
   Sam/0000-0002-9545-5432
FU Medical Research Council Metabolic Diseases Unit [MC_UU_00014/5];
   Wellcome Trust [208363/Z/17/Z, WT 219417, WT 214274/Z/18/Z]; MRC
   Metabolic Diseases Unit [MC_UU_00014/1]; NIHR [CL-201914-504]; MRC
   Metabolic Disease Unit [MC_UU_00014/1]; NIHR Cambridge Biomedical
   Research Centre; NIHR Rare Disease Translational Research Collaboration;
   British Heart Foundation [RG/18/7/33636]; MRC [MC_UU_00014/2]; Deutsche
   Forschungsgemeinschaft [CRC 1052, 209933838]; Deutsches Zentrum fur
   Diabetesforschung (DZD) [82DZD00601]; Medical Research Council
   [MR/M004422/1, MR/R023131/1]; Wellcome Trust; Medical Research Council;
   European Union; Chronic Disease Research Foundation (CDRF); Zoe Global
   Ltd; National Institute for Health Research (NIHR) BioResource, Clinical
   Research Facility and Biomedical Research Centre based at Guy's and St
   Thomas' NHS Foundation Trust; King's College London; MRC [MC_UU_00014/5,
   MR/M004422/1, MC_UU_00014/2, MC_UU_00014/1, MR/R023131/1] Funding
   Source: UKRI
FX This work was supported by the Medical Research Council Metabolic
   Diseases Unit [MC_UU_00014/5] and the Wellcome Trust Major Award
   [208363/Z/17/Z]. J.A.T is supported by the MRC Metabolic Diseases Unit
   (MC_UU_00014/1) and by a NIHR Clinical Lectureship (CL-201914-504).
   D.B.S (WT 219417) and S.O. are supported by the Wellcome Trust (WT
   214274/Z/18/Z), the MRC Metabolic Disease Unit (MC_UU_00014/1), and the
   NIHR Cambridge Biomedical Research Centre and NIHR Rare Disease
   Translational Research Collaboration. S.V. and G.B. are supported by The
   British Heart Foundation (RG/18/7/33636), and by the MRC
   (MC_UU_00014/2). M.B and E.G-J. was supported by the Deutsche
   Forschungsgemeinschaft through CRC 1052, project number 209933838,
   subproject B1 to M.B. and by Deutsches Zentrum fur Diabetesforschung
   (DZD, Grant: 82DZD00601) to M.B and E.G-J. KSS acknowledges funding from
   the Medical Research Council (MR/M004422/1 and MR/R023131/1). TwinsUK is
   funded by the Wellcome Trust, Medical Research Council, European Union,
   Chronic Disease Research Foundation (CDRF), Zoe Global Ltd and the
   National Institute for Health Research (NIHR) BioResource, Clinical
   Research Facility and Biomedical Research Centre based at Guy's and St
   Thomas' NHS Foundation Trust in partnership with King's College London.
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NR 119
TC 18
Z9 19
U1 0
U2 8
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2212-8778
J9 MOL METAB
JI Mol. Metab.
PD NOV
PY 2022
VL 65
AR 101589
DI 10.1016/j.molmet.2022.101589
EA SEP 2022
PG 22
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 5O6UA
UT WOS:000872604500003
PM 36064109
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Chen, JT
   Kotani, K
AF Chen, Jui-Tung
   Kotani, Kazuhiko
TI Serum γ-glutamyltranspeptidase and oxidative stress in subjectively
   healthy women: an association with menopausal stages
SO AGING CLINICAL AND EXPERIMENTAL RESEARCH
LA English
DT Article
DE Alanine aminotransferase; Antioxidant; C-Reactive protein; gamma-GT;
   Reactive oxygen species
ID BODY-MASS INDEX; CARDIOVASCULAR-DISEASE; ANTHROPOMETRIC OBESITY;
   GLUTATHIONE-PEROXIDASE; SUPEROXIDE-DISMUTASE; WAIST CIRCUMFERENCE;
   METABOLIC SYNDROME; TRANSFERASE; RISK; POPULATION
AB Background Gamma-glutamyltransferase (gamma-GT) is used as a marker of alcohol-related pathology, while gamma-GT is recently considered to be an oxidative stress marker.
   Aim The present study aimed to investigate the correlation between the oxidative status and gamma-GT levels, in association with menopausal stages.
   Methods In total, 252 women, who were subjectively healthy, were divided into three groups: premenopausal, perimenopausal, and postmenopausal. The circulating oxidative status was evaluated by the diacron-reactive oxygen metabolite (d-ROM) test. In addition to serum gamma-GT, routine blood investigations, including lipid, glucose, and inflammatory parameters, were performed.
   Results The median gamma-GT level was 17 U/L and the mean d-ROM level was 335 Carr U in all subjects. On multiple regression analysis, independent significant positive correlations were observed between d-ROM and high-sensitivity CRP levels in three groups, while there was a significant positive correlation between d-ROM and gamma-GT levels only in the premenopausal group but not in the perimenopausal and postmenopausal groups.
   Discussion The significant relationship between d-ROM and gamma-GT at active estrogen stage may indicate a different oxidative stress condition by memopausal stage. The reasons of this relationship should be further explored.
   Conclusion A positive relationship between d-ROM and gamma-GT levels, both as known as oxidative stress-related markers, could exist in premenopausal women.
C1 [Chen, Jui-Tung] Akasaka Kaikan B1F, JT Chen Clin, Minato Ku, 2-13-5 Akasaka, Tokyo 1070052, Japan.
   [Kotani, Kazuhiko] Jichi Med Univ, Div Community & Family Med, 3311-1 Yakushiji, Shimotsuke, Tochigi 3290498, Japan.
C3 Jichi Medical University
RP Chen, JT (corresponding author), Akasaka Kaikan B1F, JT Chen Clin, Minato Ku, 2-13-5 Akasaka, Tokyo 1070052, Japan.
EM chin-cl@m.jcnnet.jp
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NR 42
TC 2
Z9 3
U1 0
U2 3
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1594-0667
EI 1720-8319
J9 AGING CLIN EXP RES
JI Aging Clin. Exp. Res.
PD AUG
PY 2016
VL 28
IS 4
BP 619
EP 624
DI 10.1007/s40520-015-0460-y
PG 6
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA DQ2LW
UT WOS:000379034800004
PM 26438207
DA 2025-06-11
ER

PT J
AU Wentworth, BA
   Stein, MB
   Redwine, LS
   Xue, Y
   Taub, PR
   Clopton, P
   Nayak, KR
   Maisel, AS
AF Wentworth, Bailey A.
   Stein, Murray B.
   Redwine, Laura S.
   Xue, Yang
   Taub, Pam R.
   Clopton, Paul
   Nayak, Keshav R.
   Maisel, Alan S.
TI Post-Traumatic Stress Disorder A Fast Track to Premature
   Cardiovascular Disease?
SO CARDIOLOGY IN REVIEW
LA English
DT Review
DE post-traumatic stress disorder; cardiovascular disease; biomarkers;
   MR-proADM; copeptin
ID PITUITARY-ADRENAL AXIS; CORONARY-HEART-DISEASE; C-REACTIVE PROTEIN;
   SALIVARY CORTISOL; WAR VETERANS; MYOCARDIAL-INFARCTION; LIPID
   CONCENTRATIONS; PLATELET REACTIVITY; TRAUMATIC STRESS; IMMUNE FUNCTION
AB An increasing body of evidence reported in the literature indicates a possible role for post-traumatic stress disorder (PTSD) as a cause for cardiovascular disease (CVD). However, mechanistic evidence on the progression of adverse cardiac outcomes in PTSD is lacking. In this review, we examine the potential paths by which CVD could occur in those with PTSD. Dysregulation of the hypothalamic-pituitary-adrenal axis and autonomic nervous dysfunction are commonly observed in PTSD, which in turn leads to a variety of physiological changes potentially damaging to the heart. Increased inflammation, dysfunction of the vascular endothelium, hypercoagulability, and cardiac hyperreactivity all have been noted in patients with PTSD. Altered neurochemistry, most notably increased arginine vasopressin, as well as an increased prevalence of the metabolic syndrome, may also contribute to adverse cardiac outcomes. Although the association between PTSD and physical disease is often complicated by health risk behaviors or comorbid psychiatric conditions, the evidence for a link between PTSD and CVD is substantial. In our examination, we attempt to identify potential cardiac biomarkers that may be useful in detecting increased cardiac risk in patients with PTSD. As research in this area is exceedingly limited, we hope to inspire further research, as there is great potential value in identifying prognostically useful cardiac biomarkers so as to predict and prevent the onset of CVD in patients with PTSD.
C1 [Wentworth, Bailey A.; Stein, Murray B.; Redwine, Laura S.; Xue, Yang; Taub, Pam R.; Maisel, Alan S.] Univ Calif San Diego, Dept Psychiat & Behav Med, La Jolla, CA 92093 USA.
   [Xue, Yang; Taub, Pam R.; Clopton, Paul; Maisel, Alan S.] VA San Diego Healthcare Syst, Dept Cardiol, San Diego, CA USA.
   [Nayak, Keshav R.] Balboa Naval Hosp, San Diego, CA USA.
C3 University of California System; University of California San Diego; US
   Department of Veterans Affairs; Veterans Health Administration (VHA); VA
   San Diego Healthcare System; United States Department of Defense; United
   States Navy; Naval Medical Center San Diego
RP Wentworth, BA (corresponding author), Univ Calif San Diego, Dept Psychiat & Behav Med, 9500 Gilman Dr,MC 0804, La Jolla, CA 92093 USA.
EM bwentwor@ucsd.edu
RI redwine, laura/B-3093-2009
OI Redwine, Laura/0000-0001-7633-2034; Taub, Pam/0000-0002-0684-0655
FU Alere; Abbott; Nanosphere; BG Diagnostics; Gilead
FX Dr. Alan Maisel consults and has research activities with a number of
   biomarker companies, although there is no specific conflict with this
   manuscript. Consultant at Alere. Grants from Alere, Abbott, Nanosphere,
   BG Diagnostics, Gilead. Member of Advisory Board at EFG Inc., Critical
   Diagnostics.
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NR 97
TC 92
Z9 101
U1 0
U2 50
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1061-5377
EI 1538-4683
J9 CARDIOL REV
JI Cardiol. Rev.
PD JAN-FEB
PY 2013
VL 21
IS 1
BP 16
EP 22
DI 10.1097/CRD.0b013e318265343b
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 049TI
UT WOS:000312005900003
PM 22717656
DA 2025-06-11
ER

PT J
AU Mattson, MP
   Wan, RQ
AF Mattson, MP
   Wan, RQ
TI Beneficial effects of intermittent fasting and caloric restriction on
   the cardiovascular and cerebrovascular systems
SO JOURNAL OF NUTRITIONAL BIOCHEMISTRY
LA English
DT Article
DE heart rate variability; ischemia; insulin sensitivity; oxidative stress;
   stroke
ID ENDOTHELIAL GROWTH-FACTOR; ISCHEMIC BRAIN-DAMAGE; DIETARY RESTRICTION;
   NEUROTROPHIC FACTOR; OXIDATIVE STRESS; LIFE-SPAN; MYOCARDIAL-INFARCTION;
   ENERGY RESTRICTION; INSULIN-RESISTANCE; METABOLIC SYNDROME
AB Intermittent fasting (IF; reduced meal frequency) and caloric restriction (CR) extend lifespan and increase resistance to age-related diseases in rodents and monkeys and improve the health of overweight humans. Both IF and CR enhance cardiovascular and brain functions and improve several risk factors for coronary artery disease and stroke including a reduction in blood pressure and increased insulin sensitivity. Cardiovascular stress adaptation is improved and heart rate variability is increased in rodents maintained on an IF or a CR diet. Moreover, rodents maintained on an IF regimen exhibit increased resistance of heart and brain cells to ischemic injury in experimental models of myocardial infarction and stroke. The beneficial effects of IF and CR result from at least two mechanisms reduced oxidative damage and increased cellular stress resistance. Recent findings suggest that some of the beneficial effects of IF on both the cardiovascular system and the brain are mediated by brain-derived neurotrophic factor signaling in the brain. Interestingly, cellular and molecular effects of IF and CR on the cardiovascular system and the brain are similar to those of regular physical exercise, suggesting shared mechanisms. A better understanding of the cellular and molecular mechanisms by which IF and CR affect the blood vessels and heart and brain cells will likely lead to novel preventative and therapeutic strategies for extending health span. (c) 2005 Elsevier Inc. All rights reserved.
C1 NIA, Neurosci Lab, Intramural Res Program, Baltimore, MD 21224 USA.
C3 National Institutes of Health (NIH) - USA; NIH National Institute on
   Aging (NIA)
RP NIA, Neurosci Lab, Intramural Res Program, Baltimore, MD 21224 USA.
EM mausonm@grc.nia.nih.gov
RI Mattson, Mark/F-6038-2012
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NR 80
TC 343
Z9 397
U1 1
U2 165
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0955-2863
EI 1873-4847
J9 J NUTR BIOCHEM
JI J. Nutr. Biochem.
PD MAR
PY 2005
VL 16
IS 3
BP 129
EP 137
DI 10.1016/j.jnutbio.2004.12.007
PG 9
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA 908TL
UT WOS:000227813000001
PM 15741046
OA Bronze
DA 2025-06-11
ER

PT J
AU Piao, L
   Choi, J
   Kwon, G
   Ha, H
AF Piao, Lingjuan
   Choi, Jiyeon
   Kwon, Guideock
   Ha, Hunjoo
TI Endogenous catalase delays high-fat diet-induced liver injury in mice
SO KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY
LA English
DT Article
DE Catalase; Insulin resistance; NAFLD; Oxidative stress; Peroxisome
ID INDUCED INSULIN-RESISTANCE; INCREASED OXIDATIVE STRESS; METABOLIC
   SYNDROME; HYDROGEN-PEROXIDE; DISEASE; PEROXISOMES; OBESITY;
   MITOCHONDRIAL; INFLAMMATION; DYSFUNCTION
AB Non-alcoholic fatty liver disease (NAFLD) has become the most prevalent liver disease in parallel with worldwide epidemic of obesity. Reactive oxygen species (ROS) contributes to the development and progression of NAFLD. Peroxisomes play an important role in fatty acid oxidation and ROS homeostasis, and catalase is an antioxidant exclusively expressed in peroxisome. The present study examined the role of endogenous catalase in early stage of NAFLD. 8-week-old male catalase knock-out (CKO) and age-matched C57BL/6J wild type (WT) mice were fed either a normal diet (ND: 18% of total calories from fat) or a high fat diet (HFD: 60% of total calories from fat) for 2 weeks. CKO mice gained body weight faster than WT mice at early period of HFD feeding. Plasma triglyceride and ALT, fasting plasma insulin, as well as liver lipid accumulation, inflammation (F4/80 staining), and oxidative stress (8-oxo-dG staining and nitrotyrosine level) were significantly increased in CKO but not in WT mice at 2 weeks of HFD feeding. While phosphorylation of Akt (Ser473) and PGC1 alpha mRNA expression were decreased in both CKO and WT mice at HFD feeding, GSK3 beta phosphorylation and Cox4-il mRNA expression in the liver were decreased only in CKO-HF mice. Taken together, the present data demonstrated that endogenous catalase exerted beneficial effects in protecting liver injury including lipid accumulation and inflammation through maintaining liver redox balance from the early stage of HFD-induced metabolic stress.
C1 [Piao, Lingjuan; Choi, Jiyeon; Kwon, Guideock; Ha, Hunjoo] Ewha Womans Univ, Coll Pharm, Grad Sch Pharmaceut Sci, Seoul 03760, South Korea.
C3 Ewha Womans University
RP Ha, H (corresponding author), Ewha Womans Univ, Coll Pharm, Grad Sch Pharmaceut Sci, Seoul 03760, South Korea.
EM hha@ewha.ac.kr
OI Ha, Hunjoo/0000-0002-5601-1265
FU NLRL through the National Research Foundation (NRF) of Korea
   [2016R1A2B4006575]
FX This work was financially supported by NLRL through the National
   Research Foundation (NRF) of Korea (No. 2016R1A2B4006575). We are
   grateful to native speaker Ms. Debra Dorotea for her excellent language
   correction.
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NR 24
TC 31
Z9 34
U1 0
U2 11
PU KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY
PI SEOUL
PA C/O EDITORIAL OFFICE, 448-13 SEOKYO-DONG, SEOUL, SOUTH KOREA
SN 1226-4512
EI 2093-3827
J9 KOREAN J PHYSIOL PHA
JI KOREAN J. PHYSIOL. PHARMACOL.
PD MAY
PY 2017
VL 21
IS 3
BP 317
EP 325
DI 10.4196/kjpp.2017.21.3.317
PG 9
WC Pharmacology & Pharmacy; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Physiology
GA EU7KX
UT WOS:000401214800006
PM 28461774
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Liu, J
   Zhou, L
   Xiong, KM
   Godlewski, G
   Mukhopadhyay, B
   Tam, J
   Yin, S
   Gao, P
   Shan, X
   Pickel, J
   Bataller, R
   O'Hare, J
   Scherer, T
   Buettner, C
   Kunos, G
AF Liu, Jie
   Zhou, Liang
   Xiong, Keming
   Godlewski, Grzegorz
   Mukhopadhyay, Bani
   Tam, Joseph
   Yin, Shi
   Gao, Peter
   Shan, Xin
   Pickel, James
   Bataller, Ramon
   O'Hare, James
   Scherer, Thomas
   Buettner, Christoph
   Kunos, George
TI Hepatic Cannabinoid Receptor-1 Mediates Diet-Induced Insulin Resistance
   via Inhibition of Insulin Signaling and Clearance in Mice
SO GASTROENTEROLOGY
LA English
DT Article
DE NASH; Signal Transduction; Mouse Model; Liver Disease
ID ENDOPLASMIC-RETICULUM STRESS; INDUCED OBESE MICE; RANDOMIZED
   CONTROLLED-TRIAL; BOUND TRANSCRIPTION FACTOR; CB1 RECEPTOR; ER STRESS;
   CARDIOMETABOLIC RISK; DEGRADING ENZYME; ADIPOSE-TISSUE; GLUCOSE
AB BACKGROUND & AIMS: Obesity-related insulin resistance contributes to cardiovascular disease. Cannabinoid receptor-1 (CB1) blockade improves insulin sensitivity in obese animals and people, suggesting endocannabinoid involvement. We explored the role of hepatic CB1 in insulin resistance and inhibition of insulin signaling pathways. METHODS: Wild-type mice and mice with disruption of CB1 (CB1-/- mice) or with hepatocyte-specific deletion or transgenic overexpression of CB1 were maintained on regular chow or a high-fat diet (HFD) to induce obesity and insulin resistance. Hyperinsulinemic-euglycemic clamp analysis was used to analyze the role of the liver and hepatic CB1 in HFD-induced insulin resistance. The cellular mechanisms of insulin resistance were analyzed in mouse and human isolated hepatocytes using small interfering or short hairpin RNAs and lentiviral knockdown of gene expression. RESULTS: The HFD induced hepatic insulin resistance in wild-type mice, but not in CB1-/-mice or mice with hepatocyte-specific deletion of CB1. CB1-/-mice that overexpressed CB1 specifically in hepatocytes became hyperinsulinemic as a result of reduced insulin clearance due to down-regulation of the insulin-degrading enzyme. However, they had increased hepatic glucose production due to increased glycogenolysis, indicating hepatic insulin resistance; this was further increased by the HFD. In mice with hepatocytes that express CB1, the HFD or CB1 activation induced the endoplasmic reticulum stress response via activation of the Bip-PERK-eIF2 alpha protein translation pathway. In hepatocytes isolated from human or mouse liver, CB1 activation caused endoplasmic reticulum stress-dependent suppression of insulin-induced phosphorylation of akt-2 via phosphorylation of IRS1 at serine-307 and by inducing the expression of the serine and threonine phosphatase Phlpp1. Expression of CB1 was up-regulated in samples from patients with nonalcoholic fatty liver disease. CONCLUSIONS: Endocannabinoids contribute to diet-induced insulin resistance in mice via hepatic CB1-mediated inhibition of insulin signaling and clearance.
C1 [Liu, Jie; Zhou, Liang; Xiong, Keming; Godlewski, Grzegorz; Mukhopadhyay, Bani; Tam, Joseph; Yin, Shi; Gao, Peter; Shan, Xin; Kunos, George] NIAAA, Lab Physiol Studies, Bethesda, MD 20892 USA.
   [Pickel, James] NIMH, Genet Lab, NIH, Bethesda, MD 20892 USA.
   [Bataller, Ramon] Inst Invest Biomed August Pi & Sunyer, Liver Unit, Barcelona, Spain.
   [O'Hare, James; Scherer, Thomas; Buettner, Christoph] Mt Sinai Sch Med, Dept Med, New York, NY USA.
C3 National Institutes of Health (NIH) - USA; NIH National Institute on
   Alcohol Abuse & Alcoholism (NIAAA); National Institutes of Health (NIH)
   - USA; NIH National Institute of Mental Health (NIMH); University of
   Barcelona; Hospital Clinic de Barcelona; IDIBAPS; Icahn School of
   Medicine at Mount Sinai
RP Liu, J (corresponding author), NIAAA, Lab Physiol Studies, 5625 Fishers Lane,MSC-9413, Bethesda, MD 20892 USA.
EM jiel@mail.nih.gov
RI Yin, Shi/GPX-3723-2022; Buettner, Christoph/F-5793-2013
OI Scherer, Thomas/0000-0003-4980-706X; Bataller, Ramon/0000-0002-1119-7799
FU National Institute on Alcohol Abuse and Alcoholism
FX Supported by intramural funds from the National Institute on Alcohol
   Abuse and Alcoholism.
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NR 56
TC 146
Z9 152
U1 0
U2 17
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0016-5085
EI 1528-0012
J9 GASTROENTEROLOGY
JI Gastroenterology
PD MAY
PY 2012
VL 142
IS 5
BP 1218
EP +
DI 10.1053/j.gastro.2012.01.032
PG 12
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 930CK
UT WOS:000303113600040
PM 22307032
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Swe, MT
   Thongnak, L
   Jaikumkao, K
   Pongchaidecha, A
   Chatsudthipong, V
   Lungkaphin, A
AF Swe, Myat Theingi
   Thongnak, Laongdao
   Jaikumkao, Krit
   Pongchaidecha, Anchalee
   Chatsudthipong, Varanuj
   Lungkaphin, Anusorn
TI Dapagliflozin not only improves hepatic injury and pancreatic
   endoplasmic reticulum stress, but also induces hepatic gluconeogenic
   enzymes expression in obese rats
SO CLINICAL SCIENCE
LA English
DT Article
ID INADEQUATE GLYCEMIC CONTROL; NONALCOHOLIC FATTY LIVER; ACTIVATED
   PROTEIN-KINASE; TYPE-2 DIABETIC-PATIENTS; BETA-CELL FAILURE;
   INSULIN-RESISTANCE; SKELETAL-MUSCLE; DOUBLE-BLIND; GLUCOSE; SIRT1
AB Background: With an increasing prevalence of obesity and metabolic syndrome, exploring the effects and delineating the mechanisms of possible therapeutic agents are of critical importance. We examined the effects of SGLT2 inhibitor-dapagliflozin on insulin resistance, hepatic gluconeogenesis, hepatic injury and pancreatic ER stress in high-fat diet-induced obese rats.
   Materials and methods: Male Wistar rats were fed with normal diet (ND) or high-fat diet for 16 weeks. Then high-fat rats were given vehicle (HF) or dapagliflozin (1 mg/kg/day; HFDapa) or metformin (30 mg/kg/day; HFMet) for another 4 weeks.
   Results: We found that dapagliflozin ameliorated high-fat diet-induced insulin resistance. The fasting plasma glucose level was comparable among groups, although dapagliflozin treatment led to substantial glycosuria. Hepatic gluconeogenic enzymes, PEPCK, G6Pase and FBPase, expression was not different in HF rats compared with ND rats. Meanwhile, dapagliflozin-treated group exhibited the elevation of these enzymes in parallel with the rise of transcription factor CREB, co-factor PGC1 alpha and upstream regulator SI RT1. Hepatic oxidative stress, inflammation and NAFLD activity score as well as hepatic and pancreatic ER stress and apoptosis in obese rats were attenuated by dapagliflozin.
   Conclusion: We conclude that dapagliflozin improved obesity-related insulin resistance, hepatic and pancreatic injury independent of fasting plasma glucose level. Of note, dapagliflozin-induced glycosuria apparently triggered the up-regulation of hepatic gluconeogenic enzymes to prevent hypoglycemia.
C1 [Swe, Myat Theingi; Thongnak, Laongdao; Pongchaidecha, Anchalee; Lungkaphin, Anusorn] Chiang Mai Univ, Fac Med, Dept Physiol, Chiang Mai, Thailand.
   [Swe, Myat Theingi] Univ Med 2, Dept Physiol, Yangon, Myanmar.
   [Jaikumkao, Krit] Chiang Mai Univ, Fac Associated Med Sci, Dept Radiol Technol, Chiang Mai, Thailand.
   [Chatsudthipong, Varanuj] Mahidol Univ, Fac Sci, Res Ctr Transport Prot Med Innovat, Bangkok, Thailand.
   [Lungkaphin, Anusorn] Chiang Mai Univ, Funct Food Res Ctr Well Being, Chiang Mai, Thailand.
C3 Chiang Mai University; Chiang Mai University; Mahidol University; Chiang
   Mai University
RP Lungkaphin, A (corresponding author), Chiang Mai Univ, Fac Med, Dept Physiol, Chiang Mai, Thailand.; Lungkaphin, A (corresponding author), Chiang Mai Univ, Funct Food Res Ctr Well Being, Chiang Mai, Thailand.
EM anusom.lungka@cmu.ac.th
RI Jaikumkao, Krit/IUN-9587-2023
OI Lungkaphin, Anusorn/0000-0003-4522-0026
FU Thailand Research Fund [TRF-RSA 6080015]; Faculty of Medicine Research
   Fund [100-2562]; scholarship for Doctoral degree in Physiology
   (International Program), Faculty of Medicine, Chiang Mai University;
   Graduate Research Scholarship for the Fiscal Year 2561 Graduate School
   Chiang Mai University; Functional Food Research Center for Well-being,
   Chiang Mai University
FX This work was supported by the Thailand Research Fund [TRF-RSA 6080015
   (to A.L.)]; Faculty of Medicine Research Fund [Grant number 100-2562 (to
   A.L.)]; scholarship for Doctoral degree in Physiology (International
   Program), Faculty of Medicine, Chiang Mai University; and Graduate
   Research Scholarship for the Fiscal Year 2561 Graduate School Chiang Mai
   University (to M.S.); and the Functional Food Research Center for
   Well-being, Chiang Mai University (to A.L.).
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NR 67
TC 60
Z9 63
U1 0
U2 7
PU PORTLAND PRESS LTD
PI LONDON
PA 5TH FLR, 90 HIGH HOLBORN, LONDON WC1V 6LJ, ENGLAND
SN 0143-5221
EI 1470-8736
J9 CLIN SCI
JI Clin. Sci.
PD DEC
PY 2019
VL 133
IS 23
BP 2415
EP 2430
DI 10.1042/CS20190863
PG 16
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA KI2SD
UT WOS:000511199500004
PM 31769484
DA 2025-06-11
ER

PT J
AU Escribano-Lopez, I
   Diaz-Morales, N
   Rovira-Llopis, S
   de Marañon, AM
   Orden, S
   Alvarez, A
   Bañuls, C
   Rocha, M
   Murphy, MP
   Hernandez-Mijares, A
   Victor, VM
AF Escribano-Lopez, Irene
   Diaz-Morales, Noelia
   Rovira-Llopis, Susana
   de Maranon, Arantxa Martinez
   Orden, Samuel
   Alvarez, Angeles
   Banuls, Celia
   Rocha, Milagros
   Murphy, Michael P.
   Hernandez-Mijares, Antonio
   Victor, Victor M.
TI The mitochondria-targeted antioxidant MitoQ modulates oxidative stress,
   inflammation and leukocyte-endothelium interactions in leukocytes
   isolated from type 2 diabetic patients
SO REDOX BIOLOGY
LA English
DT Article
DE Leukocytes; Oxidative stress; Inflammation; Endothelium; Type 2
   diabetes; MitoQ
ID LEUKOCYTE/ENDOTHELIAL CELL-INTERACTIONS; KAPPA-B ACTIVATION; METABOLIC
   SYNDROME; DYSFUNCTION; NEPHROPATHY; ATHEROSCLEROSIS; OVEREXPRESSION;
   ASSOCIATION; MECHANISMS; OBESITY
AB It is not known if the mitochondria-targeted antioxidants such as mitoquinone (MitoQ) can modulate oxidative stress and leukocyte-endothelium interactions in T2D patients.
   We aimed to evaluate the beneficial effect of MitoQ on oxidative stress parameters and leukocyte-endothelium interactions in leukocytes of T2D patients.
   The study population consisted of 98 T2D patients and 71 control subjects. We assessed metabolic and anthropometric parameters, mitochondrial reactive oxygen species (ROS) production, glutathione peroxidase 1 (GPX-1), NF kappa B-p65, TNF alpha and leukocyte-endothelium interactions.
   Diabetic patients exhibited higher weight, BMI, waist circumference, SBP, DBP, glucose, insulin, HOMA-IR, HbA1c, triglycerides, hs-CRP and lower HDL-c with respect to controls.
   Mitochondrial ROS production was enhanced in T2D patients and decreased by MitoQ. The antioxidant also increased GPX-1 levels and PMN rolling velocity and decreased PMN rolling flux and PMN adhesion in T2D patients. NF kappa B-p65 and TNF alpha were augmented in T2D and were both reduced by MitoQ treatment.
   Our findings support that the antioxidant MitoQ has an anti-inflammatory and antioxidant action in the leukocytes of T2D patients by decreasing ROS production, leukocyte-endothelium interactions and TNF alpha through the action of NF kappa B. These data suggest that mitochondria-targeted antioxidants such as MitoQ should be investigated as a novel means of preventing cardiovascular events in T2D patients.
C1 [Escribano-Lopez, Irene; Diaz-Morales, Noelia; Rovira-Llopis, Susana; de Maranon, Arantxa Martinez; Banuls, Celia; Rocha, Milagros; Hernandez-Mijares, Antonio; Victor, Victor M.] Univ Hosp Doctor Peset, Fdn Promot Hlth & Biomed Res Valencian Reg FISABI, Serv Endocrinol, Valencia, Spain.
   [Rovira-Llopis, Susana; Banuls, Celia; Rocha, Milagros; Hernandez-Mijares, Antonio; Victor, Victor M.] Univ Valencia, Inst Hlth Res INCLIVA, Valencia, Spain.
   [Orden, Samuel; Rocha, Milagros; Victor, Victor M.] Univ Valencia, CIBERehd Dept Pharmacol & Physiol, Valencia, Spain.
   [Murphy, Michael P.] MRC Mitochondrial Biol Unit, Cambridge, England.
   [Hernandez-Mijares, Antonio] Univ Valencia, Dept Med, Valencia, Spain.
   [Victor, Victor M.] Univ Valencia, Dept Physiol, Valencia, Spain.
C3 University of Valencia; CIBER - Centro de Investigacion Biomedica en
   Red; CIBEREHD; University of Valencia; University of Valencia;
   University of Valencia
RP Victor, VM (corresponding author), Univ Hosp Doctor Peset, FISABIO, Avda Gaspar Aguilar 90, Valencia 46017, Spain.
EM victor.victor@uv.es
RI Alvarez, Angeles/ABF-4589-2020; victor, victor/Q-4843-2019; Murphy,
   Michael/C-2120-2009; Diaz-Morales, Noelia/H-1978-2015; Rovira-Llopis,
   Susana/AAX-8666-2021; Banuls, Celia/H-7359-2017; Martinez de Maranon
   Peris, Aranzazu/H-4399-2017; Rocha, Milagros/I-4987-2015
OI Murphy, Michael/0000-0003-1115-9618; Alvarez,
   Angeles/0000-0002-2301-9746; Diaz-Morales, Noelia/0000-0003-1657-2700;
   Rovira-Llopis, Susana/0000-0002-8476-5128; VICTOR,
   VICTOR/0000-0002-3027-3945; Banuls, Celia/0000-0001-8077-7642; Martinez
   de Maranon Peris, Aranzazu/0000-0002-4153-0396; Rocha,
   Milagros/0000-0003-2923-6546
FU Carlos III Health Institute [PI13/01025, PI13/00073, PI15/01424,
   PI16/1083, CIBERehd CB06/04/0071, CP10/0360, FI14/00125, CD14/00043];
   Ministry of Education of the Valencian Regional Government [PROMETEOII
   2014/035, GV/2016/169]; Foundation for the Promotion of Health and
   Biomedical Research in the Valencian Region (FISABIO) [UGP-14-93,
   UGP-14-95, UGP15-193]; Ministerio de Economia y Competitividad [SAF2015
   67678 R]; European Regional Development Fund (ERDF "A way to build
   Europe"); Ministry of Health of the Valencian Regional Government
   [CES10/030]; MRC [MC_U105663142] Funding Source: UKRI
FX This study was financed by grants PI13/01025, PI13/00073, PI15/01424,
   PI16/1083 and CIBERehd CB06/04/0071 by Carlos III Health Institute,
   PROMETEOII 2014/035 and GV/2016/169 by Ministry of Education of the
   Valencian Regional Government, UGP-14-93, UGP-14-95, UGP15-193 by
   Foundation for the Promotion of Health and Biomedical Research in the
   Valencian Region (FISABIO), SAF2015 67678 R by Ministerio de Economia y
   Competitividad and by the European Regional Development Fund (ERDF "A
   way to build Europe"). V.M.V. and M.R. are recipients of contracts from
   the Ministry of Health of the Valencian Regional Government and Carlos
   III Health Institute (CES10/030 and CP10/0360, respectively). N.D-M. is
   recipient of a predoctoral fellowship from Carlos III Health Institute
   (FI14/00125). C.B. is recipient of a postdoctoral contract from Carlos
   III Health Institute (CD14/00043).
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NR 43
TC 81
Z9 85
U1 2
U2 23
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2213-2317
J9 REDOX BIOL
JI Redox Biol.
PD DEC
PY 2016
VL 10
BP 200
EP 205
DI 10.1016/j.redox.2016.10.017
PG 6
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA EF8SD
UT WOS:000390598800020
PM 27810734
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Lumeng, JC
   Miller, A
   Peterson, KE
   Kaciroti, N
   Sturza, J
   Rosenblum, K
   Vazquez, DM
AF Lumeng, Julie C.
   Miller, Alison
   Peterson, Karen E.
   Kaciroti, Niko
   Sturza, Julie
   Rosenblum, Katherine
   Vazquez, Delia M.
TI Diurnal cortisol pattern, eating behaviors and overweight in low-income
   preschool-aged children
SO APPETITE
LA English
DT Article
DE Child; Obesity; Overweight; Stress; Eating behavior; Cortisol
ID BODY-MASS INDEX; SALIVARY CORTISOL; METABOLIC SYNDROME; CHILDHOOD
   OBESITY; STRESS; SECRETION; INTERVENTION; SYSTEM; RISK
AB This study examined, among children, the associations among chaos in the home, diurnal cortisol patterns, eating behaviors and being overweight. Participants included 331 low-income children aged 3-4 years. Mean salivary cortisol-intercept (representing morning peak, 60 min since waking) and cortisol-slope (representing diurnal decline after peak) were calculated using mixed models from samples obtained across 3 days. Parents reported chaos in the home by questionnaire and responded to the Children's Eating Behavior Questionnaire, generating subscales Food Responsiveness (FR), Emotional Overeating (EO), Enjoyment of Food (EF), and Satiety Responsiveness (SR). Body mass index was categorized a overweight vs. not. Path analysis evaluated associations among chaos, cortisol patterns, eating behaviors, and weight status. Children living in more chaotic homes had lower morning cortisol levels, consistent with "hypocortisolism" reported among individuals who have experienced significant allostatic load as a result of substantial early life chronic stress. Among girls, the hypocortisolism pattern predicted a higher likelihood of being overweight both directly and mediated through reduced Satiety Responsiveness; in boys, the association of the hypocortisolism pattern with being overweight was mediated entirely through Emotional Overeating. In summary, our results provide support for the conceptual model that psychosocial stress contributes to hypocortisolism, which contributes directly to a higher likelihood of being overweight in girls, and indirectly through reduced Satiety Responsiveness in girls and through increased Emotional Overeating in boys. (C) 2013 Elsevier Ltd. All rights reserved.
C1 [Lumeng, Julie C.; Miller, Alison; Peterson, Karen E.; Kaciroti, Niko; Sturza, Julie; Rosenblum, Katherine; Vazquez, Delia M.] Univ Michigan, Ctr Human Growth & Dev, Ann Arbor, MI 48109 USA.
   [Lumeng, Julie C.; Peterson, Karen E.; Vazquez, Delia M.] Univ Michigan, Sch Med, Dept Pediat, Ann Arbor, MI 48109 USA.
   [Lumeng, Julie C.] Univ Michigan, Sch Publ Hlth, Human Nutr Program, Dept Environm Hlth Sci, Ann Arbor, MI 48109 USA.
   [Miller, Alison] Univ Michigan, Sch Publ Hlth, Dept Hlth Behav & Hlth Educ, Ann Arbor, MI 48109 USA.
   [Peterson, Karen E.] Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA.
   [Peterson, Karen E.] Harvard Univ, Sch Publ Hlth, Dept Soc Human Dev & Hlth, Boston, MA 02115 USA.
   [Rosenblum, Katherine; Vazquez, Delia M.] Univ Michigan, Sch Med, Dept Psychiat, Ann Arbor, MI 48109 USA.
C3 University of Michigan System; University of Michigan; University of
   Michigan System; University of Michigan; University of Michigan System;
   University of Michigan; University of Michigan System; University of
   Michigan; Harvard University; Harvard T.H. Chan School of Public Health;
   Harvard University; Harvard T.H. Chan School of Public Health;
   University of Michigan System; University of Michigan
RP Lumeng, JC (corresponding author), Univ Michigan, Ctr Human Growth & Dev, 300 North Ingalls St,10th Floor, Ann Arbor, MI 48109 USA.
EM jlumeng@umich.edu
RI Kaciroti, Niko/AAG-3988-2021; Rosenblum, Katherine/AAC-5921-2019
OI Kaciroti, Niko/0000-0001-8843-8231; Rosenblum,
   Katherine/0000-0001-6952-9672; Miller, Alison/0000-0002-9866-0204;
   Vazquez, Delia/0000-0003-3621-4759
FU NIH [5RC1DK086376]; National Institute of Diabetes and Digestive and
   Kidney Diseases [P30DK020572, P30DK092926] Funding Source: NIH RePORTER
FX All phases of this study were supported by a grant from NIH, Grant
   #5RC1DK086376 to Dr. Lumeng.
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NR 37
TC 81
Z9 93
U1 0
U2 30
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 0195-6663
EI 1095-8304
J9 APPETITE
JI Appetite
PD FEB 1
PY 2014
VL 73
BP 65
EP 72
DI 10.1016/j.appet.2013.10.016
PG 8
WC Behavioral Sciences; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Behavioral Sciences; Nutrition & Dietetics
GA 293FW
UT WOS:000329957800010
PM 24177439
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Patterson, ZR
   Khazall, R
   MacKay, H
   Anisman, H
   Abizaid, A
AF Patterson, Z. R.
   Khazall, R.
   MacKay, H.
   Anisman, H.
   Abizaid, A.
TI Central Ghrelin Signaling Mediates the Metabolic Response of C57BL/6
   Male Mice to Chronic Social Defeat Stress
SO ENDOCRINOLOGY
LA English
DT Article
ID PITUITARY-ADRENAL RESPONSES; ENDOCANNABINOID RELEASE; PARAVENTRICULAR
   NUCLEUS; RECEPTOR ANTAGONIST; PLASMA GHRELIN; RAT; HYPOTHALAMUS; BRAIN;
   CONSEQUENCES; ADIPOSITY
AB Chronic stressors promote metabolic disturbances, including obesity and metabolic syndrome. Ghrelin, a peptide that promotes appetite and the accumulation of adipose tissue, is also secreted in response to stressors to protect the brain and peripheral tissues from the effects of these stressors. Here we demonstrate that elevated ghrelin levels produced by chronic exposure to social stress are associated with increased caloric intake and body weight gain in male C57BL mice. In contrast, stressed mice lacking ghrelin receptors (GHSR KO mice) or C57BL mice receiving chronic intracerebroventricular delivery of the ghrelin receptor antagonist [D-Lys(3)]-GHRP-6 show attenuated weight gain and feeding responses under the same social stress paradigm. Interestingly, stressed GHSR KO mice showed depleted sc and intrascapular brown fat depots, whereas stressed young wild-type mice did not. In old wild-type mice, chronic social defeat increased visceral and intrascapular brown fat depots in association with increases in obesity markers like hyperleptinemia and hyperinsulinemia along with increased hypothalamic expression of neuropeptide Y and Agouti related peptide. Importantly, the elevated expression of these peptides persisted least for 2 weeks after cessation of the stressor regimen. In contrast, old GHSR KO mice did not show these alterations after chronic social defeat. These results suggest that ghrelin plays an important role in the metabolic adaptations necessary to meet the energetic demands posed by stressors, but chronic exposure to stress-induced ghrelin elevations ultimately could lead to long lasting metabolic dysfunctions. (Endocrinology 154: 1080-1091, 2013)
C1 [Patterson, Z. R.; Khazall, R.; MacKay, H.; Anisman, H.; Abizaid, A.] Carleton Univ, Dept Neurosci, Ottawa, ON K1S 5B6, Canada.
C3 Carleton University
RP Abizaid, A (corresponding author), Carleton Univ, Dept Neurosci, 1125 Colonel Dr, Ottawa, ON K1S 5B6, Canada.
EM alfonso_abizaid@carleton.ca
OI Abizaid, Alfonso/0000-0001-9303-3511
FU Natural Sciences and Engineering Research Council of Canada Postgraduate
   Doctoral Scholarship; Ontario Graduate scholarships; Canadian Institutes
   for Health Research operating grant
FX This work was supported by a Natural Sciences and Engineering Research
   Council of Canada Postgraduate Doctoral Scholarship (to Z.P.), Ontario
   Graduate scholarships (to R. K. and H. M.), and by a Canadian Institutes
   for Health Research operating grant (to A.A.).
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NR 62
TC 86
Z9 96
U1 0
U2 26
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0013-7227
EI 1945-7170
J9 ENDOCRINOLOGY
JI Endocrinology
PD MAR
PY 2013
VL 154
IS 3
BP 1080
EP 1091
DI 10.1210/en.2012-1834
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 094VR
UT WOS:000315293100011
PM 23341196
OA Bronze
DA 2025-06-11
ER

PT J
AU Evans, JL
   Maddux, BA
   Goldfine, ID
AF Evans, JL
   Maddux, BA
   Goldfine, ID
TI The molecular basis for oxidative stress-induced insulin resistance
SO ANTIOXIDANTS & REDOX SIGNALING
LA English
DT Review
ID ACTIVATED PROTEIN-KINASE; TYROSINE-PHOSPHATASE 1B;
   NECROSIS-FACTOR-ALPHA; FREE-RADICAL THEORY; L6 MUSCLE-CELLS; RECEPTOR
   SUBSTRATE-1; HYDROGEN-PEROXIDE; GLUCOSE-TRANSPORT; SERINE
   PHOSPHORYLATION; BETA-SUBUNIT
AB Reactive oxygen and nitrogen molecules have been typically viewed as the toxic by-products of metabolism. However, accumulating evidence has revealed that reactive species, including hydrogen peroxide, serve as signaling molecules that are involved in the regulation of cellular function. The chronic and/or increased production of these reactive molecules or a reduced capacity for their elimination, termed oxidative stress, can lead to abnormal changes in intracellular signaling and result in chronic inflammation and insulin resistance. Inflammation and oxidative stress have been linked to insulin resistance in vivo. Recent studies have found that this association is not restricted to insulin resistance in type 2 diabetes, but is also evident in obese, nondiabetic individuals, and in those patients with the metabolic syndrome. An increased concentration of reactive molecules triggers the activation of serine/threonine kinase cascades such as c-jun N-terminal kinase, nuclear factor-kappa B, and others that in turn phosphorylate multiple targets, including the insulin receptor and the insulin receptor substrate (IRS) proteins. Increased serine phosphorylation of IRS reduces its ability to undergo tyrosine phosphorylation and may accelerate the degradation of IRS-1, offering an attractive explanation for the molecular basis of oxidative stress-induced insulin resistance. Consistent with this idea, studies with antioxidants such as vitamin E, alpha-lipoic acid, and N-acetylcysteine indicate a beneficial impact on insulin sensitivity, and offer the possibility for new treatment approaches for insulin resistance.
C1 Med Res Inst, San Francisco, CA 94107 USA.
   Univ Calif San Francisco, San Francisco, CA USA.
   Med Res Inst, San Francisco, CA USA.
C3 University of California System; University of California San Francisco
RP Med Res Inst, 444 De Haro St,Suite 209, San Francisco, CA 94107 USA.
EM jevansphd@earthlink.net
RI Evans, Joseph/N-4501-2013
OI Evans, Joseph/0000-0002-9334-1650
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NR 157
TC 469
Z9 534
U1 2
U2 50
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1523-0864
EI 1557-7716
J9 ANTIOXID REDOX SIGN
JI Antioxid. Redox Signal.
PD JUL-AUG
PY 2005
VL 7
IS 7-8
BP 1040
EP 1052
DI 10.1089/ars.2005.7.1040
PG 13
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 942ZU
UT WOS:000230322200023
PM 15998259
DA 2025-06-11
ER

PT J
AU Trzeciak, AR
   Mohanty, JG
   Jacob, KD
   Barnes, J
   Ejiogu, N
   Lohani, A
   Zonderman, AB
   Rifkind, JM
   Evans, MK
AF Trzeciak, Andrzej R.
   Mohanty, Joy G.
   Jacob, Kimberly D.
   Barnes, Janice
   Ejiogu, Ngozi
   Lohani, Althaf
   Zonderman, Alan B.
   Rifkind, Joseph M.
   Evans, Michele K.
TI Oxidative damage to DNA and single strand break repair capacity:
   Relationship to other measures of oxidative stress in a population
   cohort
SO MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
LA English
DT Article
DE Oxidative stress; Aging; DNA oxidative lesions; DNA repair; Comet assay;
   Red blood cell glutathione (RBC GSH); Fluorescent heme degradation
   products; High-sensitivity C-reactive protein (hs-CRP)
ID RED-BLOOD-CELLS; COMET ASSAY; HUMAN-LYMPHOCYTES; HYDROGEN-PEROXIDE; HEME
   DEGRADATION; IONIZING-RADIATION; METABOLIC SYNDROME; BASE DAMAGE; AGE;
   RACE
AB It is well accepted that oxidative DNA repair capacity, oxidative damage to DNA and oxidative stress play central roles in aging and disease development. However, the correlation between oxidative damage to DNA, markers of oxidant stress and DNA repair capacity is unclear. In addition, there is no universally accepted panel of markers to assess oxidative stress in humans. Our interest is oxidative damage to DNA and its correlation with DNA repair capacity and other markers of oxidative stress. We present preliminary data from a small comet study that attempts to correlate single strand break (SSB) level with single strand break repair capacity (SSB-RC) and markers of oxidant stress and inflammation. In this limited study of four very small age-matched 24-individual groups of male and female whites and African-Americans aged 30-64 years, we found that females have higher single strand break (SSB) levels than males (p = 0.013). There was a significant negative correlation between SSB-RC and SSB level (p = 0.041). There was a positive correlation between SSBs in African American males with both heme degradation products (p=0.008) and high-sensitivity C-reactive protein (hs-CRP) (p = 0.022). We found a significant interaction between hs-CRP and sex in their effect on residual DNA damage (p =0.002). Red blood cell reduced glutathione concentration was positively correlated with the levels of oxidized bases detected by endonuclease III (p= 0.047), heme degradation products (p = 0.015) and hs-CRP (p= 0.020). However, plasma carbonyl levels showed no significant correlation with other markers. The data from the literature and from our very limited study suggest a complex relationship between measures of oxidative stress and frequently used clinical parameters believed to reflect inflammation or oxidative stress. Published by Elsevier B.V.
C1 [Trzeciak, Andrzej R.; Jacob, Kimberly D.; Barnes, Janice; Lohani, Althaf; Evans, Michele K.] NIA, Lab Mol Biol & Immunol, NIH, Baltimore, MD 21224 USA.
   [Mohanty, Joy G.; Rifkind, Joseph M.] NIA, Mol Dynam Sect, NIH, Baltimore, MD 21224 USA.
   [Zonderman, Alan B.] NIA, Lab Behav Neurosci, NIH, Baltimore, MD 21224 USA.
   [Ejiogu, Ngozi; Evans, Michele K.] NIA, Clin Res Branch, NIH, Baltimore, MD 21224 USA.
C3 National Institutes of Health (NIH) - USA; NIH National Institute on
   Aging (NIA); National Institutes of Health (NIH) - USA; NIH National
   Institute on Aging (NIA); National Institutes of Health (NIH) - USA; NIH
   National Institute on Aging (NIA); National Institutes of Health (NIH) -
   USA; NIH National Institute on Aging (NIA)
RP Evans, MK (corresponding author), NIA, Lab Mol Biol & Immunol, NIH, Baltimore, MD 21224 USA.
EM evansmi@mail.nih.gov
RI Evans, Michele/AAE-4776-2019; Zonderman, Alan/A-5807-2013; Ezike,
   Ngozi/AAL-3075-2021
OI Evans, Michele/0000-0002-8546-2831; Zonderman, Alan
   B/0000-0002-6523-4778
FU NIH, National Institute on Aging; National Institute on Minority Healthy
   and Health Disparities
FX Endonuclease III was a generous gift from Dr. Andrew R. Collins
   (University of Oslo, Oslo, Norway). We thank Drs. Nicole Noren Hooten,
   Kotb Abdelmohsen, and Larry J. Brant for valuable discussions. We also
   thank nurses Catherine Sackett, Mary Sam-Nwoha, and Patricia
   Julien-Williams who work in the HANDLS study for their careful
   assessment of the participants and the acquisition of clinical samples.
   This research was supported by the Intramural Research Program of the
   NIH, National Institute on Aging and the National Institute on Minority
   Healthy and Health Disparities.
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NR 49
TC 34
Z9 37
U1 0
U2 18
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0027-5107
J9 MUTAT RES-FUND MOL M
JI Mutat. Res.-Fundam. Mol. Mech. Mutagen.
PD AUG 1
PY 2012
VL 736
IS 1-2
SI SI
BP 93
EP 103
DI 10.1016/j.mrfmmm.2012.01.002
PG 11
WC Biotechnology & Applied Microbiology; Genetics & Heredity; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Genetics & Heredity; Toxicology
GA 999BK
UT WOS:000308283900013
PM 22273780
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Pollicino, F
   Veronese, N
   Dominguez, LJ
   Barbagallo, M
AF Pollicino, Francesco
   Veronese, Nicola
   Dominguez, Ligia J.
   Barbagallo, Mario
TI Mediterranean diet and mitochondria: New findings
SO EXPERIMENTAL GERONTOLOGY
LA English
DT Article
DE Mediterranean diet; Mitochondria; Stress; Inflammation; Dementia;
   Metabolic syndrome
ID HUMAN SKELETAL-MUSCLE; POLYUNSATURATED FATTY-ACIDS; HEPATIC STEATOSIS;
   ADIPOSE-TISSUE; GUT MICROBIOTA; LIVER-DISEASE; STRESS; DYSFUNCTION;
   BIOGENESIS; MEN
AB Mitochondria are subcellular organelles known for their central role in several energetic processes. Accumulating evidence supports a key role for mitochondria in the physiological response to both acute and chronic stress exposure, and, ultimately, the biological embedding of adversity in health and psychological functioning that increases the interest of these organelles in several medical conditions typical of older people. At the same time, Mediterranean diet (MedDiet) seems to affect the function of mitochondria further justifying the role of this diet in lowering the risk of negative health outcomes. In this review, we have elucidated the role of mitochondria in human diseases including the fundamental role in stress, aging, and neuropsychiatric and metabolic disorders. Overall, MedDiet can limit the production of free radicals, being rich in polyphenols. Moreover, MedDiet reduced mitochondrial reactive oxygen species (mtROS) production and ameliorated mitochondrial damage and apoptosis. Similarly, whole grains can maintain the mitochondrial respiration and membrane potential, finally improving mitochondrial function. Other components of MedDiet can have anti-inflammatory effects, again modulating mitochondrial function. For example, delphinidin (a flavonoid present in red wine and berries) restored the elevated level of mitochondrial respiration, mtDNA content, and complex IV activity; similarly, resveratrol and lycopene, present in grapefruits and tomatoes, exerted an anti-inflammatory effect modulating mitochondrial enzymes. Altogether, these findings support the notion that several positive effects of MedDiet can be mediated by a modulation in mitochondrial function indicating the necessity of further studies in human beings for finally confirming these findings.
C1 [Pollicino, Francesco; Veronese, Nicola; Dominguez, Ligia J.; Barbagallo, Mario] G DAlessandro PROMISE Univ Palermo, Dept Hlth Promot Maternal & Infant Care, Internal Med & Med Specialties, I-90127 Palermo, Italy.
   [Dominguez, Ligia J.] Univ Kore Enna, Sch Med & Surg, Enna, Italy.
   [Veronese, Nicola] Univ Palermo, Dept Internal Med & Geriatr, Geriatr Unit, Via Vespro 141, I-90127 Palermo, Italy.
C3 Universita Kore di ENNA; University of Palermo
RP Veronese, N (corresponding author), Univ Palermo, Dept Internal Med & Geriatr, Geriatr Unit, Via Vespro 141, I-90127 Palermo, Italy.
EM nicola.veronese@unipa.it
RI BARBAGALLO, MARIO/K-4794-2017; Barbara, C./AAF-3397-2020; Veronese,
   Nicola/K-4343-2018
OI Veronese, Nicola/0000-0002-9328-289X
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NR 103
TC 26
Z9 26
U1 2
U2 12
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0531-5565
EI 1873-6815
J9 EXP GERONTOL
JI Exp. Gerontol.
PD JUN 1
PY 2023
VL 176
AR 112165
DI 10.1016/j.exger.2023.112165
EA APR 2023
PG 10
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA F2MM9
UT WOS:000980738100001
PM 37019345
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Dornas, W
   Schuppan, D
AF Dornas, Waleska
   Schuppan, Detlef
TI Mitochondrial oxidative injury: a key player in nonalcoholic fatty liver
   disease
SO AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
LA English
DT Review
DE autophagy; liver fibrosis; mitophagy; nonalcoholic steatohepatitis;
   peroxisome proliferator-activated receptor-gamma coactivator 1; reactive
   oxygen species; uncoupling protein
ID PROLIFERATOR-ACTIVATED RECEPTOR; HEPATIC CYTOCHROME-P450 2E1;
   GAMMA-COACTIVATOR 1-ALPHA; NITRIC-OXIDE; UNCOUPLING PROTEIN-2;
   INSULIN-RESISTANCE; STEATOHEPATITIS PATHOGENESIS; RESPIRATORY-CHAIN; ATP
   HOMEOSTASIS; OBESE MICE
AB Nonalcoholic fatty liver disease (NAFLD) has become the most prevalent liver disease worldwide. NAFLD is tightly linked to the metabolic syndrome, insulin resistance, and oxidative stress. Globally, its inflammatory form, nonalcoholic steatohepatitis (NASH), has become the main cause of liver-related morbidity and mortality, mainly due to liver cirrhosis and primary liver cancer. One hallmark of NASH is the presence of changes in mitochondrial morphology and function that are accompanied by a blocked flow of electrons in the respiratory chain, which increases formation of mitochondrial reactive oxygen species in a self-perpetuating vicious cycle. Consequences are oxidation of DNA bases and mitochondrial DNA depletion that are coupled with genetic and acquired mitochondrial DNA mutations, all impairing the resynthesis of respiratory chain polypeptides. In general, several maladaptations of pathways that usually maintain energy homeostasis occur with the early and late excess metabolic stress in NAFLD and NASH. We discuss the interplay between hepatocyte mitochondrial stress and inflammatory responses, focusing primarily on events initiated and maintained by mitochondrial free radical-induced damage in NAFLD. Importantly, mitochondrial oxidative stress and dysfunction are modulated by key pharmacological targets that are related to excess production of reactive oxygen species, mitochondrial turnover and the mitochondrial unfolded protein response, mitophagy, and mitochondrial biogenesis. However, the efficacy of such interventions depends on NAFLD/NASH disease stage.
C1 [Dornas, Waleska] Univ Fed Sao Paulo, Ctr Cellular & Mol Therapy, Dept Biochem, Sao Paulo, Brazil.
   [Dornas, Waleska; Schuppan, Detlef] Johannes Gutenberg Univ Mainz, Univ Med Ctr, Inst Translat Immunol, Mainz, Germany.
   [Dornas, Waleska; Schuppan, Detlef] Johannes Gutenberg Univ Mainz, Univ Med Ctr, Res Ctr Immune Therapy, Mainz, Germany.
   [Schuppan, Detlef] Harvard Med Sch, Beth Israel Deaconess Med Ctr, Div Gastroenterol, Boston, MA 02115 USA.
C3 Universidade Federal de Sao Paulo (UNIFESP); Johannes Gutenberg
   University of Mainz; Johannes Gutenberg University of Mainz; Harvard
   University; Harvard Medical School; Harvard University Medical
   Affiliates; Beth Israel Deaconess Medical Center
RP Schuppan, D (corresponding author), Johannes Gutenberg Univ Mainz, Univ Med Ctr, Inst Translat Immunol, Mainz, Germany.; Schuppan, D (corresponding author), Johannes Gutenberg Univ Mainz, Univ Med Ctr, Res Ctr Immune Therapy, Mainz, Germany.; Schuppan, D (corresponding author), Harvard Med Sch, Beth Israel Deaconess Med Ctr, Div Gastroenterol, Boston, MA 02115 USA.
EM detlef.schuppan@unimedizin-mainz.de.de
RI Schuppan, Detlef/AER-9743-2022
FU European Union Horizon 2020 Grant [634413, 777377]; German Research
   Foundation (DFG) Collaborative Research Centre (CRC) [DFG CRC 1066/B3,
   DFG CRC 1292/08]
FX D. Schuppan receives project-related support from European Union Horizon
   2020 Grant Agreements 634413 [European Project on Steatohepatitis
   (EPoS)] and 777377 [Liver Investigation on Marker Utility in
   Steatohepatitis (LITMUS)] and from German Research Foundation (DFG)
   Collaborative Research Centre (CRC) Project Grants DFG CRC 1066/B3 and
   DFG CRC 1292/08.
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NR 129
TC 64
Z9 65
U1 2
U2 26
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0193-1857
EI 1522-1547
J9 AM J PHYSIOL-GASTR L
JI Am. J. Physiol.-Gastroint. Liver Physiol.
PD SEP
PY 2020
VL 319
IS 3
BP G400
EP G411
DI 10.1152/ajpgi.00121.2020
PG 12
WC Gastroenterology & Hepatology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Physiology
GA NW7OE
UT WOS:000575207700007
PM 32597705
DA 2025-06-11
ER

PT J
AU Alfaradhi, MZ
   Fernandez-Twinn, DS
   Martin-Gronert, MS
   Musial, B
   Fowden, A
   Ozanne, SE
AF Alfaradhi, Maria Z.
   Fernandez-Twinn, Denise S.
   Martin-Gronert, Malgorzata S.
   Musial, Barbara
   Fowden, Abigail
   Ozanne, Susan E.
TI Oxidative stress and altered lipid homeostasis in the programming of
   offspring fatty liver by maternal obesity
SO AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE
   PHYSIOLOGY
LA English
DT Article
DE developmental programming; nonalcoholic fatty liver disease; oxidative
   stress; metabolism; maternal obesity
ID INSULIN-RESISTANCE; GENE-EXPRESSION; METABOLIC SYNDROME; WEIGHT-LOSS;
   FED RATS; DISEASE; MICE; LIPOGENESIS; DIET; REESTERIFICATION
AB Changes in the maternal nutritional environment during fetal development can influence offspring's metabolic risk in later life. Animal models have demonstrated that offspring of diet-induced obese dams develop metabolic complications, including nonalcoholic fatty liver disease. In this study we investigated the mechanisms in young offspring that lead to the development of nonalcoholic fatty liver disease (NAFLD). Female offspring of C57BL/6J dams fed either a control or obesogenic diet were studied at 8 wk of age. We investigated the roles of oxidative stress and lipid metabolism in contributing to fatty liver in offspring. There were no differences in body weight or adiposity at 8 wk of age; however, offspring of obese dams were hyperinsulinemic. Oxidative damage markers were significantly increased in their livers, with reduced levels of the antioxidant enzyme glutathione peroxidase-1. Mitochondrial complex I and II activities were elevated, while levels of mitochondrial cytochrome c were significantly reduced and glutamate dehydrogenase was significantly increased, suggesting mitochondrial dysfunction. Offspring of obese dams also had significantly greater hepatic lipid content, associated with increased levels of PPAR gamma and reduced triglyceride lipase. Liver glycogen and protein content were concomitantly reduced in offspring of obese dams. In conclusion, offspring of diet-induced obese dams have disrupted liver metabolism and develop NAFLD prior to any differences in body weight or body composition. Oxidative stress may play a mechanistic role in the progression of fatty liver in these offspring.
C1 [Alfaradhi, Maria Z.; Fernandez-Twinn, Denise S.; Martin-Gronert, Malgorzata S.; Ozanne, Susan E.] Univ Cambridge, Addenbrookes Hosp, Wellcome Trust MRC, Inst Metab Sci,Metab Res Labs, Cambridge CB2 0QQ, England.
   [Musial, Barbara; Fowden, Abigail] Univ Cambridge, Ctr Trophoblast Res, Dept Physiol Dev & Neurosci, Cambridge CB2 0QQ, England.
C3 University of Cambridge; Cambridge University Hospitals NHS Foundation
   Trust; Addenbrooke's Hospital; University of Cambridge
RP Alfaradhi, MZ (corresponding author), Univ Cambridge, Addenbrookes Hosp, Wellcome Trust MRC, Inst Metab Sci,Metab Res Labs, Level 4,Box 289, Cambridge CB2 0QQ, England.
EM mza22@cam.ac.uk
RI ; Fernandez-Twinn, Denise/B-3881-2011
OI Ozanne, Susan/0000-0001-8753-5144; Fernandez-Twinn,
   Denise/0000-0003-2610-277X
FU Biotechnology and Biological Sciences Research Council [BB/F015364/1]
   Funding Source: Medline; British Heart Foundation [FS/09/029/27902]
   Funding Source: Medline; Medical Research Council [MC_UU_12012/4,
   G0600717, MC_UU_12012/5] Funding Source: Medline; BBSRC [BB/F015364/1]
   Funding Source: UKRI; MRC [MC_UU_12012/4, MC_UU_12012/5, G0600717]
   Funding Source: UKRI
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NR 42
TC 108
Z9 113
U1 0
U2 20
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0363-6119
EI 1522-1490
J9 AM J PHYSIOL-REG I
JI Am. J. Physiol.-Regul. Integr. Comp. Physiol.
PD JUL 1
PY 2014
VL 307
IS 1
BP R26
EP R34
DI 10.1152/ajpregu.00049.2014
PG 9
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA AL1YG
UT WOS:000338921900004
PM 24789994
OA Green Published, hybrid, Green Submitted
DA 2025-06-11
ER

PT J
AU Alves, I
   Araújo, EMQ
   Dalgaard, LT
   Singh, S
   Borsheim, E
   Carvalho, E
AF Alves, Ines
   Araujo, Edilene Maria Queiroz
   Dalgaard, Louise T.
   Singh, Sharda
   Borsheim, Elisabet
   Carvalho, Eugenia
TI Protective Effects of Sulforaphane Preventing Inflammation and Oxidative
   Stress to Enhance Metabolic Health: A Narrative Review
SO NUTRIENTS
LA English
DT Review
DE sulforaphane; Nrf2; inflammation and oxidative stress; metabolic
   diseases; nutraceutical; metabolic syndrome; healthy aging
ID TYPE-2 DIABETIC-PATIENTS; BROCCOLI SPROUTS; ENDOTHELIAL DYSFUNCTION;
   ANTIOXIDANT MECHANISMS; CRUCIFEROUS VEGETABLES; INSULIN-RESISTANCE;
   SKELETAL-MUSCLE; MOUSE MODEL; NRF2; ACTIVATION
AB The worldwide obesity epidemic has led to a drastic increase in diabetes and cardiovascular disease in younger generations. Further, maintaining metabolic health during aging is frequently a challenge due to poor diets and decreased mobility. In this setting, bioactive nutrients that are naturally occurring antioxidants, such as sulforaphane (SFN), are of high nutritional interest. SFN, a bioactive compound that is present in cruciferous vegetables, is a molecule that protects cells from cytotoxic damage and mitigates oxidative stress, protecting against disease. It exerts its action through the activation of the transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2). Many studies have been performed in animals and humans to evaluate its effects on cancer, brain health, and neurodegenerative disorders. However, fewer clinical studies have been performed to evaluate its effects on insulin resistance and the development of type 2 diabetes mellitus (T2DM) across the lifespan. Given that, in some parts of the world, particularly in Europe, the population is growing older at a significant rate, it is crucial to promote healthy habits (healthy foods, dietary pattern, precision nutrition, and physical activity) from an early stage in life and across the lifespan to avoid debilitating health conditions occurring during adulthood and aging. Thus, in this narrative review, we discuss the protective effects of SFN supplementation on inflammatory and oxidative stress pathways and relate them to metabolic disease.
C1 [Alves, Ines] Univ Porto, Inst Res & Innovat Hlth i3S, P-4200135 Porto, Portugal.
   [Alves, Ines; Borsheim, Elisabet] Arkansas Childrens Res Inst, Little Rock, AR 72202 USA.
   [Araujo, Edilene Maria Queiroz] Univ Estado Bahia, Nutr Genom & Metab Dysfunct Res & Extens Ctr, Dept Life Sci, BR-41195001 Salvador, BA, Brazil.
   [Dalgaard, Louise T.] Roskilde Univ, Dept Sci & Environm, Univ Vej 1, DK-4000 Roskilde, Denmark.
   [Singh, Sharda] Texas Tech Univ Med Sci Ctr, Dept Internal Med, Div Hematol & Oncol, Lubbock, TX 79430 USA.
   [Borsheim, Elisabet] Univ Arkansas Med Sci, Dept Pediat, Little Rock, AR 72202 USA.
   [Borsheim, Elisabet] Univ Arkansas Med Sci, Dept Geriatr, Little Rock, AR 72202 USA.
   [Borsheim, Elisabet] Arkansas Childrens Nutr Ctr, Little Rock, AR 72202 USA.
   [Carvalho, Eugenia] Univ Coimbra, CNC UC Ctr Neurosci & Cell Biol, P-3004504 Coimbra, Portugal.
   [Carvalho, Eugenia] Univ Coimbra, CIBB Ctr Innovat Biomed & Biotechnol, P-3004504 Coimbra, Portugal.
   [Carvalho, Eugenia] Univ Coimbra, Inst Interdisciplinar Res, P-3030789 Coimbra, Portugal.
C3 Universidade do Porto; i3S - Instituto de Investigacao e Inovacao em
   Saude, Universidade do Porto; Universidade do Estado Bahia; Roskilde
   University; University of Arkansas System; University of Arkansas
   Medical Sciences; University of Arkansas System; University of Arkansas
   Medical Sciences; Universidade de Coimbra; Universidade de Coimbra;
   Universidade de Coimbra
RP Carvalho, E (corresponding author), Univ Coimbra, CNC UC Ctr Neurosci & Cell Biol, P-3004504 Coimbra, Portugal.; Carvalho, E (corresponding author), Univ Coimbra, CIBB Ctr Innovat Biomed & Biotechnol, P-3004504 Coimbra, Portugal.; Carvalho, E (corresponding author), Univ Coimbra, Inst Interdisciplinar Res, P-3030789 Coimbra, Portugal.
EM inesa@ipatimup.pt; emaraujo@uneb.br; ltd@ruc.dk;
   sharda.singh@ttuhsc.edu; eborsheim@uams.edu; ecarvalh@cnc.uc.pt
RI Dalgaard, Louise/O-3788-2015; Alves, Inês/AAR-6181-2021; Carvalho,
   Eugenia/AAV-6868-2021
OI Alves, Ines/0000-0002-3914-7101; Maria Queiroz Araujo,
   Edilene/0000-0003-0481-037X; Carvalho, Eugenia/0000-0001-6264-3632
FU European Regional Development Fund through the Centro 2020 Regional
   Operation Programme under the project Healthy Aging; COMPETE 2020
   Operational Program for Competitiveness and Internalisation and
   Portuguese national funds via Fundacao para a Ciencia e a Tecnologia
   (FCT), I. P, Portugal [UIDB/04539/2020, UIDP/04539/2020,
   LA/P/0058/2020]; USDA/ARS; Portuguese Foundation for Science and
   Technology (FCT); BIAL Foundation; Portuguese Medical Association;
   Nucleo de Estudos de Doencas Autoimunes and Portuguese Society of
   Internal Medicine (NEDAI-SPMI) and; European Society for Clinical
   Investigation (ESCI Exploratory Research Grant); European Union; 
   [2020-CENTRO-01-0145-FEDER-000012];  [POCI-01-0145-FEDER-007440]; 
   [6026-10700-001-000D];  [2022.00337. CEECIND];  [101080329]
FX This research was funded by the European Regional Development Fund
   through the Centro 2020 Regional Operation Programme under the project
   Healthy Aging 2020-CENTRO-01-0145-FEDER-000012 and through the COMPETE
   2020 Operational Program for Competitiveness and Internalisation and
   Portuguese national funds via Fundacao para a Ciencia e a Tecnologia
   (FCT), I. P, Portugal, under projects POCI-01-0145-FEDER-007440,
   UIDB/04539/2020, UIDP/04539/2020, and LA/P/0058/2020. EB is partially
   supported by USDA/ARS 6026-10700-001-000D. IA acknowledges the
   Portuguese Foundation for Science and Technology (FCT) for funding
   (2022.00337. CEECIND), BIAL Foundation and Portuguese Medical
   Association (Maria de Sousa Award 2023), Nucleo de Estudos de Doencas
   Autoimunes and Portuguese Society of Internal Medicine (NEDAI-SPMI) and
   from European Society for Clinical Investigation (ESCI Exploratory
   Research Grant 2024), and finally, by the European Union's Horizon
   Europe project PAS GRAS ID 101080329.
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NR 146
TC 2
Z9 2
U1 4
U2 4
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD FEB
PY 2025
VL 17
IS 3
AR 428
DI 10.3390/nu17030428
PG 22
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA W5D5F
UT WOS:001418779300001
PM 39940284
OA gold
DA 2025-06-11
ER

PT J
AU Lin, KJ
   Wang, TJ
   Chen, SD
   Lin, KL
   Liou, CW
   Lan, MY
   Chuang, YC
   Chuang, JH
   Wang, PW
   Lee, JJ
   Wang, FS
   Lin, HY
   Lin, TK
AF Lin, Kai-Jung
   Wang, Tzu-Jou
   Chen, Shang-Der
   Lin, Kai-Lieh
   Liou, Chia-Wei
   Lan, Min-Yu
   Chuang, Yao-Chung
   Chuang, Jiin-Haur
   Wang, Pei-Wen
   Lee, Jong-Jer
   Wang, Feng-Sheng
   Lin, Hung-Yu
   Lin, Tsu-Kung
TI Two Birds One Stone: The Neuroprotective Effect of Antidiabetic Agents
   on Parkinson Disease-Focus on Sodium-Glucose Cotransporter 2 (SGLT2)
   Inhibitors
SO ANTIOXIDANTS
LA English
DT Review
DE Parkinson's disease; mitochondrial dysfunction; oxidative stress; SGLT2;
   antioxidative effects; diabetes; metabolic syndrome
ID INSULIN-RESISTANCE; OXIDATIVE STRESS; MITOCHONDRIAL DYSFUNCTION;
   CARDIOVASCULAR OUTCOMES; DIABETES-MELLITUS; C VARIANT; 16189 T; RISK;
   RECEPTOR; EMPAGLIFLOZIN
AB Parkinson's disease (PD) is the second most common neurodegenerative disease after Alzheimer's disease affecting more than 1% of the population over 65 years old. The etiology of the disease is unknown and there are only symptomatic managements available with no known disease-modifying treatment. Aging, genes, and environmental factors contribute to PD development and key players involved in the pathophysiology of the disease include oxidative stress, mitochondrial dysfunction, autophagic-lysosomal imbalance, and neuroinflammation. Recent epidemiology studies have shown that type-2 diabetes (T2DM) not only increased the risk for PD, but also is associated with PD clinical severity. A higher rate of insulin resistance has been reported in PD patients and is suggested to be a pathologic driver in this disease. Oral diabetic drugs including sodium-glucose cotransporter 2 (SGLT2) inhibitors, glucagon-like peptide-1 (GLP-1) receptor agonists, and dipeptidyl peptidase-4 (DPP-4) inhibitors have been shown to provide neuroprotective effects in both PD patients and experimental models; additionally, antidiabetic drugs have been demonstrated to lower incidence rates of PD in DM patients. Among these, the most recently developed drugs, SGLT2 inhibitors may provide neuroprotective effects through improving mitochondrial function and antioxidative effects. In this article, we will discuss the involvement of mitochondrial-related oxidative stress in the development of PD and potential benefits provided by antidiabetic agents especially focusing on sglt2 inhibitors.
C1 [Lin, Kai-Jung; Wang, Tzu-Jou; Chen, Shang-Der; Lin, Kai-Lieh; Liou, Chia-Wei; Lan, Min-Yu; Chuang, Jiin-Haur; Wang, Pei-Wen; Lee, Jong-Jer; Wang, Feng-Sheng; Lin, Hung-Yu; Lin, Tsu-Kung] Kaohsiung Chang Gung Mem Hosp, Ctr Mitochondrial Res & Med, Kaohsiung 83301, Taiwan.
   [Lin, Kai-Jung; Wang, Tzu-Jou; Chen, Shang-Der; Lin, Kai-Lieh; Liou, Chia-Wei; Lan, Min-Yu; Chuang, Yao-Chung; Chuang, Jiin-Haur; Wang, Pei-Wen; Lee, Jong-Jer; Wang, Feng-Sheng; Lin, Hung-Yu; Lin, Tsu-Kung] Chang Gung Univ, Coll Med, Kaohsiung 83301, Taiwan.
   [Lin, Kai-Jung] Natl Taiwan Univ Hosp, Dept Family Med, Taipei 100225, Taiwan.
   [Wang, Tzu-Jou] Kaohsiung Chang Gung Mem Hosp, Dept Pediat, Kaohsiung 83301, Taiwan.
   [Chen, Shang-Der; Liou, Chia-Wei; Lan, Min-Yu; Chuang, Yao-Chung; Lin, Tsu-Kung] Kaohsiung Chang Gung Mem Hosp, Dept Neurol, Kaohsiung 83301, Taiwan.
   [Chen, Shang-Der; Liou, Chia-Wei; Lan, Min-Yu; Chuang, Yao-Chung; Lin, Tsu-Kung] Kaohsiung Chang Gung Mem Hosp, Ctr Parkinsons Dis, Kaohsiung 83301, Taiwan.
   [Lin, Kai-Lieh] Kaohsiung Chang Gung Mem Hosp, Dept Anesthesiol, Kaohsiung 83301, Taiwan.
   [Chuang, Jiin-Haur] Kaohsiung Chang Gung Mem Hosp, Dept Pediat Surg, Kaohsiung 83301, Taiwan.
   [Wang, Pei-Wen] Kaohsiung Chang Gung Mem Hosp, Dept Metab, Kaohsiung 83301, Taiwan.
   [Lee, Jong-Jer] Kaohsiung Chang Gung Mem Hosp, Dept Ophthalmol, Kaohsiung 83301, Taiwan.
   [Wang, Feng-Sheng] Kaohsiung Chang Gung Mem Hosp, Dept Med Res, Kaohsiung 83301, Taiwan.
   [Lin, Hung-Yu] Show Chwan Mem Hosp, Res Assistant Ctr, Changhua 500, Taiwan.
C3 Chang Gung Memorial Hospital; Chang Gung University; National Taiwan
   University; National Taiwan University Hospital; Chang Gung Memorial
   Hospital; Chang Gung Memorial Hospital; Chang Gung Memorial Hospital;
   Chang Gung Memorial Hospital; Chang Gung Memorial Hospital; Chang Gung
   Memorial Hospital; Chang Gung Memorial Hospital; Chang Gung Memorial
   Hospital; Show Chwan Memorial Hospital
RP Lin, TK (corresponding author), Kaohsiung Chang Gung Mem Hosp, Ctr Mitochondrial Res & Med, Kaohsiung 83301, Taiwan.; Lin, TK (corresponding author), Chang Gung Univ, Coll Med, Kaohsiung 83301, Taiwan.; Lin, TK (corresponding author), Kaohsiung Chang Gung Mem Hosp, Dept Neurol, Kaohsiung 83301, Taiwan.; Lin, TK (corresponding author), Kaohsiung Chang Gung Mem Hosp, Ctr Parkinsons Dis, Kaohsiung 83301, Taiwan.
EM b101101092@tmu.edu.tw; tzujouw@gmail.com; jp1916@ms4.hinet.net;
   100311039@gms.tcu.edu.tw; cwliou@ms22.hinet.net; myl@ksts.seed.net.tw;
   ycchuang@cgmh.org.tw; jhchuang@cgmh.org.tw; wangpw@cgmh.org.tw;
   tojjlee@cgmh.org.tw; wangfs@ms33.hinet.net; linhungyu700218@gmail.com;
   tklin@cgmh.org.tw
RI Wu, mingyang/ABA-7526-2021
OI Lin, Hung-Yu/0000-0002-9035-5408; Lin, Tsu-Kung/0000-0001-6656-1319;
   Lee, Jong-Jer/0000-0002-9213-0288; Chuang,
   Yao-Chung/0000-0001-9131-7385; Liou, Chia-Wei/0000-0002-9003-4065
FU Ministry of Science and Technology in Taiwa [MOST
   109-2314-B-182A-076-MY3]; Chang Gung Memorial Hospital, Medical Research
   Projects [CRRPG8K0031]
FX This work was supported by the Ministry of Science and Technology in
   Taiwa (MOST 109-2314-B-182A-076-MY3) and Chang Gung Memorial Hospital,
   Medical Research Projects (CRRPG8K0031) to T.-K.L.
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NR 186
TC 35
Z9 35
U1 1
U2 3
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD DEC
PY 2021
VL 10
IS 12
AR 1935
DI 10.3390/antiox10121935
PG 26
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA 1X1DL
UT WOS:000807202700001
PM 34943038
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Azabdaftari, A
   van der Giet, M
   Schuchardt, M
   Hennermann, JB
   Plöckinger, U
   Querfeld, U
AF Azabdaftari, Aline
   van der Giet, Markus
   Schuchardt, Mirjam
   Hennermann, Julia B.
   Ploeckinger, Ursula
   Querfeld, Uwe
TI The cardiovascular phenotype of adult patients with phenylketonuria
SO ORPHANET JOURNAL OF RARE DISEASES
LA English
DT Article
DE Phenylketonuria; Cardiovascular risk factors; Endothelial dysfunction;
   Oxidative stress; Vascular stiffness
ID HIGH-DENSITY-LIPOPROTEIN; OXIDATIVE STRESS; ARTERIAL STIFFNESS;
   RISK-FACTORS; ENDOTHELIAL DYSFUNCTION; CHOLESTEROL EFFLUX; METABOLIC
   SYNDROME; EUROPEAN-SOCIETY; PHENYLALANINE; DISEASE
AB Background Patients with Phenylketonuria (PKU) are exposed to multiple cardiovascular risk factors, but the clinical significance of these abnormalities is yet unknown. The purpose of this study was to characterize the cardiovascular phenotype in adult patients with PKU by clinical and dietary data, measurements of biochemical markers, and non-invasive examination of vascular functions. Results Twenty-three adult patients with PKU (age: 18-47 y; 30.8 +/- 8.4 y) and 28 healthy controls (age: 18-47 y; 30.1 +/- 9.1 y) were included in this study. PKU patients had significantly higher systolic and diastolic blood pressure, increased resting heart rate and a higher body mass index. Total cholesterol and non-HDL cholesterol levels were significantly increased in PKU patients, whereas plasma levels of HDL cholesterol and its subfraction HDL2 (but not HDL3) were significantly decreased. The inflammatory markers C-reactive protein and serum amyloid A protein and the serum oxidative stress marker malondialdehyde were significantly higher in patients with PKU. Venous occlusion plethysmography showed marked reduction in post-ischemic blood flow and the carotid to femoral pulse wave velocity was significantly increased demonstrating endothelial dysfunction and increased vascular stiffness. Conclusions This study shows that the cardiovascular phenotype of adult PKU patients is characterized by an accumulation of traditional cardiovascular risk factors, high levels of inflammatory and oxidative stress markers, endothelial dysfunction and vascular stiffness. These data indicate the need for early cardiovascular risk reduction in patients with PKU.
C1 [Azabdaftari, Aline; Querfeld, Uwe] Charite Univ Med Berlin, Dept Pediat, Div Gastroenterol Nephrol & Metab Dis, Campus Virchow Klinikum, Augstenburger Pl 1, D-13353 Berlin, Germany.
   [van der Giet, Markus; Schuchardt, Mirjam] Charite Univ Med Berlin, Dept Nephrol, Campus Benjamin Franklin,Hindenburgdamm 30, D-12203 Berlin, Germany.
   [Hennermann, Julia B.] Univ Med Ctr Mainz, Villa Metab, Dept Pediat & Adolescent Med, Langenbeckstr 1, D-55131 Mainz, Germany.
   [Ploeckinger, Ursula] Charite Univ Med Berlin, Interdisciplinary Ctr Metab Endocrinol Diabet & M, Campus Virchow Klinikum, Augustenburger Pl 1, D-13353 Berlin, Germany.
C3 Berlin Institute of Health; Free University of Berlin; Humboldt
   University of Berlin; Charite Universitatsmedizin Berlin; Berlin
   Institute of Health; Free University of Berlin; Humboldt University of
   Berlin; Charite Universitatsmedizin Berlin; Johannes Gutenberg
   University of Mainz; Berlin Institute of Health; Free University of
   Berlin; Humboldt University of Berlin; Charite Universitatsmedizin
   Berlin
RP Querfeld, U (corresponding author), Charite Univ Med Berlin, Dept Pediat, Div Gastroenterol Nephrol & Metab Dis, Campus Virchow Klinikum, Augstenburger Pl 1, D-13353 Berlin, Germany.
EM uwe.querfeld@charite.de
RI Schuchardt, Mirjam/AAS-3704-2021; Querfeld, Uwe/AAF-6330-2020
OI Azabdaftari, Aline/0000-0002-1597-0486; van der Giet,
   Markus/0000-0003-3590-5451; Schuchardt, Mirjam/0000-0001-7388-9611;
   Querfeld, Uwe/0000-0001-6783-3822
FU Charite-Universitatsmedizin Berlin
FX The study was supported by funds dedicated to clinical research by the
   Charite-Universitatsmedizin Berlin.
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NR 61
TC 40
Z9 41
U1 1
U2 8
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1750-1172
J9 ORPHANET J RARE DIS
JI Orphanet J. Rare Dis.
PD SEP 6
PY 2019
VL 14
IS 1
AR 213
DI 10.1186/s13023-019-1188-0
PG 11
WC Genetics & Heredity; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Genetics & Heredity; Research & Experimental Medicine
GA IW3PB
UT WOS:000484892900001
PM 31492166
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Mu, YP
   Ogawa, T
   Kawada, N
AF Mu, Yong-ping
   Ogawa, Tomohiro
   Kawada, Norifumi
TI Reversibility of fibrosis, inflammation, and endoplasmic reticulum
   stress in the liver of rats fed a methionine-choline-deficient diet
SO LABORATORY INVESTIGATION
LA English
DT Article
DE caspase; cytoglobin; hepatic stellate cells; hepatocytes; Kupffer cells;
   oxidative stress
ID CHRONIC HEPATITIS-C; INDUCED INSULIN-RESISTANCE; UNFOLDED-PROTEIN
   RESPONSE; FATTY LIVER; NONALCOHOLIC STEATOHEPATITIS; STELLATE CELLS; ER
   STRESS; HEPATOCELLULAR-CARCINOMA; TRANSLATIONAL CONTROL; OXIDATIVE
   STRESS
AB Fatty liver disease has become a health problem related to metabolic syndrome worldwide, although its molecular pathogenesis requires further study. It is also unclear whether advanced fibrosis of steatohepatitis will regress when diet is controlled. The aim of this study was to investigate whether the resolution of fibrosis occurs in steatohepatitis induced by a methionine-choline-deficient diet (MCDD). Manifestation of endoplasmic reticulum (ER) stress in this model was also studied. Nonalcoholic steatohepatitis with advanced fibrosis was induced in rats by feeding them an MCDD for 10 weeks. Instead of MCDD, a methionine-choline control diet (CD) was given for the last 2 weeks to the experimental group. Fibrosis and inflammation were determined by tissue staining. Protein and gene expressions were determined by immunoblotting and quantitative reverse transcription-PCR (RT-PCR), respectively. Expressions of caspase-7, caspase-12, glucose-regulated protein 78 (GRP78), and protein disulfide isomerase were evaluated to clarify the presence of ER stress. Changing the diet from MCDD to CD triggered the reduction of fat in hepatocytes, a decrease in inflammatory gene expression and oxidative stress, and regression of fibrosis accompanied by the disappearance of activated stellate cells and macrophages. Immunohistochemistry, immunoblotting, and RT-PCR analysis all indicated the occurrence of ER stress in steatohepatitis, while it recovered immediately after changing the diet from MCCD to CD. The ratio of hepatocyte proliferation/apoptotis increased significantly during the recovery stage. This simple experiment clearly shows that changing the diet from MCDD to a normal diet (CD) triggers the resolution of hepatic inflammatory and fibrotic reactions and hepatocyte apoptosis, suggesting that MCDD-induced steatohepatitis is also reversible. ER stress appears and disappears in association with the generation and regression of steatohepatitis, respectively, with fibrosis. Laboratory Investigation (2010) 90, 245-256; doi:10.1038/labinvest.2009.123; published online 30 November 2009
C1 [Kawada, Norifumi] Osaka City Univ, Grad Sch Med, Dept Hepatol, Abeno Ku, Osaka 5458585, Japan.
   [Mu, Yong-ping] Shanghai Publ Hlth Clin Ctr, Shanghai, Peoples R China.
C3 Osaka Metropolitan University
RP Kawada, N (corresponding author), Osaka City Univ, Grad Sch Med, Dept Hepatol, Abeno Ku, 1-4-3 Asahimachi, Osaka 5458585, Japan.
EM kawadanori@med.osaka-cu.ac.jp
RI kawada, norifumi/AAS-1367-2020
OI MU, Yongping/0000-0002-6808-8243
FU Japan Society for the Promotion of Science [18659214]; Ministry of
   Health, Labour and Welfare; Osaka City University; Grants-in-Aid for
   Scientific Research [18659214] Funding Source: KAKEN
FX NK was supported by a Grant-in-Aid for Scientific Research from the
   Japan Society for the Promotion of Science through Grant no. 18659214
   (2007), by a Grant for Research on Hepatitis from the Ministry of
   Health, Labour and Welfare (2008), and by a Trust Area Research Grant
   from Osaka City University (2008). We thank Dr Ryoko Shiga for her
   valuable discussion about this paper.
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NR 57
TC 49
Z9 61
U1 0
U2 14
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 0023-6837
EI 1530-0307
J9 LAB INVEST
JI Lab. Invest.
PD FEB
PY 2010
VL 90
IS 2
BP 245
EP 256
DI 10.1038/labinvest.2009.123
PG 12
WC Medicine, Research & Experimental; Pathology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pathology
GA 550CA
UT WOS:000274103700009
PM 19949375
OA Bronze
DA 2025-06-11
ER

PT J
AU Ai, XQ
   Lin, R
   Ali, Z
   Zhu, QJ
   Ding, L
   Shi, HT
   Hong, ML
AF Ai, Xiaoqi
   Lin, Rui
   Ali, Zeeshan
   Zhu, Qingjun
   Ding, Li
   Shi, Haitao
   Hong, Meiling
TI Seasonal changes in hepatic lipid metabolism and apoptosis in Chinese
   soft-shelled turtle ( Pelodiscus sinensis )
SO COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
LA English
DT Article
DE Apoptosis; Endoplasmic reticulum stress; Hibernation; Lipid metabolism;
   Pelodiscus sinensis
ID ENDOPLASMIC-RETICULUM STRESS; MOLECULAR-MECHANISMS; HIBERNATION;
   EXPRESSION; HOMEOSTASIS; PRINCIPLES; CHAPERONE; LIFE; FAT
AB Chinese soft-shelled turtle ( Pelodiscus sinensis ) hibernates without eating and drinking when the ambient temperature is very low. To better understand the characteristics of energy utilization during hibernation, the turtles in the physiological phases of summer active (SA), Pre -Hibernation (Pre -H), Mid -Hibernation (Mid -H) and early arousal (EA) were sampled. The results showed that the levels of serum triglyceride and hepatic lipid droplet were markedly increased in Pre -H and decreased in Mid -H compared with that in SA, indicating that P. sinensis experiences lipid accumulation in Pre -H and lipid is the predominant energy reserve during hibernation. The mRNA expression levels of genes ( FABP and CPT -2 ) involved in lipolysis and lipid oxidation were up -regulated in Mid -H, while the genes related to lipid synthesis ( FAS , ACSL-1 , ACC , elovl5 , and SCD1 ) were inhibited in Mid -H. Meanwhile, the mRNA expression levels of endoplasmic reticulum stress marker gene Bip and key genes ( ATF4 , ATF6 , and IRE1 alpha ) involving the unfolded protein response were significantly increased in Mid -H and EA. Also, the expression levels of genes ( ASK1 , JNK1 , and Bax ) associated with cell apoptosis increased in Mid -H and EA, however, the expression of Bcl2 was inhibited in Mid -H. Therefore, hibernation can cause endoplasmic reticulum stress and apoptosis. The findings will provide a theoretical framework for an animal ' s cold adaptation and offer insights into preventing and managing metabolic syndrome.
C1 [Ai, Xiaoqi; Lin, Rui; Ali, Zeeshan; Zhu, Qingjun; Ding, Li; Shi, Haitao; Hong, Meiling] Hainan Normal Univ, Coll Life Sci, Minist Educ, Key Lab Trop Anim & Plant Ecol Hainan Prov,Key Lab, Haikou, Hainan, Peoples R China.
   [Ding, Li; Hong, Meiling] Hainan Normal Univ, Coll Life Sci, 99 South Longkun Rd, Haikou 571158, Hainan, Peoples R China.
C3 Ministry of Education - China; Hainan Normal University; Hainan Normal
   University
RP Ding, L; Hong, ML (corresponding author), Hainan Normal Univ, Coll Life Sci, 99 South Longkun Rd, Haikou 571158, Hainan, Peoples R China.
EM dingli@hainnu.edu.cn; mlhong@hainnu.edu.cn
RI Zhu, Qingjun/MHR-3854-2025
FU National Natural Science Foundation of China [32160251, 32271577]
FX <BOLD>Funding</BOLD> This work was supported by the National Natural
   Science Foundation of China [grant no. 32160251, 32271577] .
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NR 40
TC 4
Z9 5
U1 1
U2 14
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1532-0456
EI 1878-1659
J9 COMP BIOCHEM PHYS C
JI Comp. Biochem. Physiol. C-Toxicol. Pharmacol.
PD JUN
PY 2024
VL 280
AR 109883
DI 10.1016/j.cbpc.2024.109883
EA MAR 2024
PG 9
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism;
   Toxicology; Zoology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism;
   Toxicology; Zoology
GA PW4R4
UT WOS:001217111200001
PM 38437998
DA 2025-06-11
ER

PT J
AU Scarl, RT
   Lawrence, CM
   Gordon, HM
   Nunemaker, CS
AF Scarl, Rachel T.
   Lawrence, C. Martin
   Gordon, Hannah M.
   Nunemaker, Craig S.
TI STEAP4: its emerging role in metabolism and homeostasis of cellular iron
   and copper
SO JOURNAL OF ENDOCRINOLOGY
LA English
DT Review
DE T2D; STEAP4; islets; beta-cells; cytokines; low-grade inflammation; iron
   homeostasis; iron overload; copper
ID 6-TRANSMEMBRANE EPITHELIAL ANTIGEN; NECROSIS-FACTOR-ALPHA;
   ADIPOSE-RELATED PROTEIN; PROSTATE 4 STEAP4; INSULIN-RESISTANCE; POSITIVE
   REGULATOR; OXIDATIVE STRESS; GLUCOSE-TOLERANCE; THALASSEMIA MAJOR;
   CRYSTAL-STRUCTURE
AB Preserving energy homeostasis in the presence of stressors such as proinflammatory cytokines and nutrient overload is crucial to maintaining normal cellular function. Six transmembrane epithelial antigen of the prostate 4 (STEAP4), a metalloreductase involved in iron and copper homeostasis, is thought to play a potentially important role in the cellular response to inflammatory stress. Genome-wide association studies have linked various mutations in STEAP4 with the development of metabolic disorders such as obesity, metabolic syndrome and type 2 diabetes. Several studies have shown that expression of Steap4 is modulated by inflammatory cytokines, hormones and other indicators of cellular stress and that STEAP4 may protect cells from damage, helping to maintain normal metabolic function. STEAP4 appears to be particularly relevant in metabolically oriented cells, such as adipocytes, hepatocytes and pancreatic islet cells. These cells struggle to maintain their function in iron or copper overloaded states, presumably due to increased oxidative stress, suggesting STEAP4's role in metal homeostasis is critical to the maintenance of cellular homeostasis in general, and in preventing the onset of metabolic disease. In this review, we explore genetic associations of STEAP4 with metabolic disorders, and we examine STEAP4 tissue expression, subcellular localization, regulation, structure and function as it relates to metabolic diseases. We then examine how STEAP4's role as a regulator of cellular iron and copper may relate to type 2 diabetes.
C1 [Scarl, Rachel T.; Gordon, Hannah M.; Nunemaker, Craig S.] Ohio Univ, Heritage Coll Osteopath Med, Diabet Inst, Athens, OH 45701 USA.
   [Scarl, Rachel T.; Gordon, Hannah M.; Nunemaker, Craig S.] Ohio Univ, Dept Biomed Sci, Heritage Coll Osteopath Med, Athens, OH 45701 USA.
   [Lawrence, C. Martin] Montana State Univ, Dept Chem & Biochem, Bozeman, MT 59717 USA.
C3 University System of Ohio; Ohio University; University System of Ohio;
   Ohio University; Montana State University System; Montana State
   University Bozeman
RP Nunemaker, CS (corresponding author), Ohio Univ, Heritage Coll Osteopath Med, Diabet Inst, Athens, OH 45701 USA.; Nunemaker, CS (corresponding author), Ohio Univ, Dept Biomed Sci, Heritage Coll Osteopath Med, Athens, OH 45701 USA.
EM nunemake@ohio.edu
RI Nunemaker, Craig/JVN-6684-2024; Lawrence, C./AAH-3420-2020
OI Lawrence, Martin/0000-0002-5398-466X
FU National Institutes of Health [R01 DK089182]; Osteopathic Heritage
   Foundation; Heritage College of Osteopathic Medicine at Ohio University
FX This work was supported by the National Institutes of Health R01
   DK089182 to C S N, the Osteopathic Heritage Foundation and the Heritage
   College of Osteopathic Medicine at Ohio University.
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NR 104
TC 83
Z9 90
U1 4
U2 28
PU BIOSCIENTIFICA LTD
PI BRISTOL
PA EURO HOUSE, 22 APEX COURT WOODLANDS, BRADLEY STOKE, BRISTOL BS32 4JT,
   ENGLAND
SN 0022-0795
EI 1479-6805
J9 J ENDOCRINOL
JI J. Endocrinol.
PD SEP
PY 2017
VL 234
IS 3
BP R123
EP R134
DI 10.1530/JOE-16-0594
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA FE0CK
UT WOS:000407888200001
PM 28576871
OA Bronze, Green Accepted
DA 2025-06-11
ER

PT J
AU Smirne, C
   Croce, E
   Di Benedetto, D
   Cantaluppi, V
   Comi, C
   Sainaghi, PP
   Minisini, R
   Grossini, E
   Pirisi, M
AF Smirne, Carlo
   Croce, Eleonora
   Di Benedetto, Davide
   Cantaluppi, Vincenzo
   Comi, Cristoforo
   Sainaghi, Pier Paolo
   Minisini, Rosalba
   Grossini, Elena
   Pirisi, Mario
TI Oxidative Stress in Non-Alcoholic Fatty Liver Disease
SO LIVERS
LA English
DT Review
DE non-alcoholic fatty liver disease; oxidative stress; antioxidants;
   metabolic syndrome; inflammation; gut microbiota; mitochondrial
   dysfunction; lipotoxicity; lipid metabolism; reactive oxygen species
ID PROLIFERATOR-ACTIVATED RECEPTOR; MAC-2 BINDING-PROTEIN; NF-KAPPA-B;
   NECROSIS-FACTOR-ALPHA; DIET-INDUCED OBESITY; INSULIN-RESISTANCE;
   GUT-MICROBIOTA; HEPATIC STEATOSIS; MITOCHONDRIAL DYSFUNCTION;
   HEPATOCELLULAR-CARCINOMA
AB Non-alcoholic fatty liver disease (NAFLD) is a challenging disease caused by multiple factors, which may partly explain why it still remains an orphan of adequate therapies. This review highlights the interaction between oxidative stress (OS) and disturbed lipid metabolism. Several reactive oxygen species generators, including those produced in the gastrointestinal tract, contribute to the lipotoxic hepatic (and extrahepatic) damage by fatty acids and a great variety of their biologically active metabolites in a "multiple parallel-hit model". This leads to inflammation and fibrogenesis and contributes to NAFLD progression. The alterations of the oxidant/antioxidant balance affect also metabolism-related organelles, leading to lipid peroxidation, mitochondrial dysfunction, and endoplasmic reticulum stress. This OS-induced damage is at least partially counteracted by the physiological antioxidant response. Therefore, modulation of this defense system emerges as an interesting target to prevent NAFLD development and progression. For instance, probiotics, prebiotics, diet, and fecal microbiota transplantation represent new therapeutic approaches targeting the gut microbiota dysbiosis. The OS and its counter-regulation are under the influence of individual genetic and epigenetic factors as well. In the near future, precision medicine taking into consideration genetic or environmental epigenetic risk factors, coupled with new OS biomarkers, will likely assist in noninvasive diagnosis and monitoring of NAFLD progression and in further personalizing treatments.
C1 [Smirne, Carlo; Croce, Eleonora; Di Benedetto, Davide; Cantaluppi, Vincenzo; Comi, Cristoforo; Sainaghi, Pier Paolo; Minisini, Rosalba; Grossini, Elena; Pirisi, Mario] Univ Piemonte Orientale, Dept Translat Med, Via Solaroli 17, I-28100 Novara, Italy.
C3 University of Eastern Piedmont Amedeo Avogadro
RP Smirne, C (corresponding author), Univ Piemonte Orientale, Dept Translat Med, Via Solaroli 17, I-28100 Novara, Italy.
EM carlo.smirne@med.uniupo.it; ec.croce@gmail.com;
   davidedibenedetto304@gmail.com; vincenzo.cantaluppi@med.uniupo.it;
   cristoforo.comi@med.uniupo.it; pierpaolo.sainaghi@med.uniupo.it;
   rosalba.minisini@med.uniupo.it; elena.grossini@med.uniupo.it;
   mario.pirisi@med.uniupo.it
RI Minisini, Rosalba/ABF-9724-2021; Cantaluppi, Vincenzo/K-8531-2016;
   Sainaghi, Pier Paolo/J-1132-2016; COMI, CRISTOFORO/A-7495-2014
OI Smirne, Carlo/0000-0002-3338-5416; CANTALUPPI,
   Vincenzo/0000-0002-4120-3555; Minisini, Rosalba/0000-0002-7548-9731;
   Sainaghi, Pier Paolo/0000-0001-8322-9158; Grossini,
   Elena/0000-0002-3012-259X; COMI, CRISTOFORO/0000-0002-6862-9468
FU Fondazione Valenza Anziani
FX Carlo Smirne is grateful to Gino Amisano and the Fondazione Valenza
   Anziani for partially funding his researcher position for studies in
   internal medicine/geriatric medicine.
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NR 421
TC 41
Z9 42
U1 1
U2 3
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2673-4389
J9 LIVERS-BASEL
JI Livers
PD MAR
PY 2022
VL 2
IS 1
BP 30
EP 76
DI 10.3390/livers2010003
PG 47
WC Gastroenterology & Hepatology
WE Emerging Sources Citation Index (ESCI)
SC Gastroenterology & Hepatology
GA WI3Y2
UT WOS:001254213300001
OA gold
DA 2025-06-11
ER

PT J
AU Ong, P
   Athanasiadis, A
   Hill, S
   Schäufele, T
   Mahrholdt, H
   Sechtem, U
AF Ong, Peter
   Athanasiadis, Anastasios
   Hill, Stephan
   Schaeufele, Tim
   Mahrholdt, Heiko
   Sechtem, Udo
TI Coronary Microvascular Dysfunction Assessed by Intracoronary
   Acetylcholine Provocation Testing Is a Frequent Cause of Ischemia and
   Angina in Patients With Exercise-Induced Electrocardiographic Changes
   and Unobstructed Coronary Arteries
SO CLINICAL CARDIOLOGY
LA English
DT Article
ID CARDIAC SYNDROME-X; CARDIOVASCULAR MAGNETIC-RESONANCE; SYNDROME
   EVALUATION WISE; CHEST-PAIN; STABLE ANGINA; RISK-FACTORS; DISEASE;
   PECTORIS; WOMEN; INFLAMMATION
AB Background: The exercise electrocardiogram (ECG) is a standard examination in patients with suspected coronary artery disease. However, despite a pathologic result, many patients undergoing diagnostic coronary angiography do not have any significant epicardial stenosis. In this study, we assessed the relation between a pathologic exercise ECG and coronary microvascular dysfunction in response to intracoronary acetylcholine (ACh) provocation in patients without any relevant epicardial stenosis.
   Hypothesis: Coronary microvascular dysfunction is significantly more often in patients with angina, unobstructed coronary arteries and a pathologic exercise stress test compared to those without pathologic stress test.
   Methods: This study recruited 137 consecutive patients with exertional angina pectoris who underwent diagnostic coronary angiography between September 2008 and April 2011 (68% women; mean age, 63 +/- 10 years). In none of the patients was there a stenosis of >50%. All patients underwent an exercise ECG before angiography and intracoronary ACh provocation testing for assessment of coronary vasomotor responses directly after angiography.
   Results: The exercise ECG showed an abnormal result in 69 patients (50%; ST-segment depression >= 0.1 mV and/or reproduction of the patient's usual symptoms). The ACh test revealed a coronary vasomotor abnormality (reproduction of the patient's symptoms, ischemic ECG shifts +/- diffuse distal vasoconstriction) in 87 patients (64%). Such a result was significantly more often found in patients with a pathologic exercise ECG (50/69 [72%] vs 19/69 [28%], P = 0.034). There were no other statistically significant differences between patients with and those without pathologic exercise ECG.
   Conclusions: Coronary microvascular dysfunction is frequently found in patients with exertional angina pectoris and unobstructed coronary arteries. Such a finding is found significantly more often in presence of a pathologic exercise ECG.
C1 [Ong, Peter; Athanasiadis, Anastasios; Hill, Stephan; Schaeufele, Tim; Mahrholdt, Heiko; Sechtem, Udo] Robert Bosch Krankenhaus, Dept Cardiol, D-70376 Stuttgart, Germany.
C3 Bosch; Robert Bosch Krankenhaus
RP Ong, P (corresponding author), Robert Bosch Krankenhaus, Dept Cardiol, Auerbachstr 110, D-70376 Stuttgart, Germany.
EM peter.ong@rbk.de
RI Sechtem, Udo/ADK-6380-2022
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NR 24
TC 38
Z9 39
U1 0
U2 3
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0160-9289
EI 1932-8737
J9 CLIN CARDIOL
JI Clin. Cardiol.
PD AUG
PY 2014
VL 37
IS 8
BP 462
EP 467
DI 10.1002/clc.22282
PG 6
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA AN3ZW
UT WOS:000340528400002
PM 24719338
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Choi, S
   Singh, I
   Singh, AK
   Khan, M
   Won, J
AF Choi, Seungho
   Singh, Inderjit
   Singh, Avtar K.
   Khan, Mushfiquddin
   Won, Jeseong
TI Asymmetric dimethylarginine exacerbates cognitive dysfunction associated
   with cerebrovascular pathology
SO FASEB JOURNAL
LA English
DT Article
DE actin stress fiber; Alzheimer's disease; asymmetric dimethylarginine
   (ADMA); brain endothelial barrier; endothelial nitric oxide synthase
   (eNOS); nitric oxide; vascular cognitive impairment and dementia (VCID)
ID NITRIC-OXIDE SYNTHASE; CEREBRAL VASOSPASM; S-NITROSOGLUTATHIONE;
   ENDOTHELIAL DYSFUNCTION; ENDOGENOUS INHIBITOR; BEHAVIORAL DEFICITS;
   PLASMA-LEVELS; BLOOD-FLOW; RAT MODEL; ADMA
AB Asymmetric dimethylarginine (ADMA), an endogenous inhibitor and uncoupler of nitric oxide synthase, has gained attention as a risk factor for cardiac disease, metabolic syndrome, and cerebrovascular disease. In this study, we investigated the role of systemic ADMA overburden in cerebromicrovascular pathology associated with cognitive dysfunction using APPSwDI transgenic mice expressing human beta-amyloid precursor protein Swedish (Tg-SwDI), a model of cerebrovascular beta-amyloidosis. To induce systemic overburden of ADMA, Tg-SwDI mice were treated with a daily dose of exogenous ADMA. ADMA treatment resulted in elevated ADMA levels in the blood and brain of Tg-SwDI mice. ADMA treatment induced the brain nitrosative stress and inflammation as well as enhanced the brain A beta deposition and cognitive impairment in Tg-SwDI mice. However, ADMA treatment had no such effects on wild type mice. ADMA treatment also exacerbated brain microvascular pathology in Tg-SwDI mice as observed by increased blood-brain barrier dysfunction, loss of tight junction proteins, increased endothelial stress fibers, and decreased microvessel density in the brain. In addition, similar observations were made in cultured human brain microvessel endothelial cells, where ADMA in the presence of VEGF-induced endothelial cell signaling for F-actin stress fiber inducing endothelial barrier dysfunction. Overall, these data document the potential role of ADMA in the cognitive pathology under conditions of cerebrovascular beta-amyloidosis.
C1 [Choi, Seungho; Singh, Inderjit; Khan, Mushfiquddin] Med Univ South Carolina, Dept Pediat, 173 Ashley Ave,DCRI Room 509, Charleston, SC 29425 USA.
   [Singh, Inderjit] Ralph H Johnson Vet Adm Med Ctr, Res Serv, Charleston, SC USA.
   [Singh, Avtar K.; Won, Jeseong] Med Univ South Carolina, Dept Pathol & Lab Med, 173 Ashley Ave,DCRI Room 510, Charleston, SC 29425 USA.
   [Singh, Avtar K.] Ralph H Johnson Vet Adm Med Ctr, Pathol & Lab Med Serv, Charleston, SC USA.
C3 Medical University of South Carolina; US Department of Veterans Affairs;
   Veterans Health Administration (VHA); Ralph H Johnson VA Medical Center;
   Medical University of South Carolina; US Department of Veterans Affairs;
   Veterans Health Administration (VHA); Ralph H Johnson VA Medical Center
RP Singh, I (corresponding author), Med Univ South Carolina, Dept Pediat, 173 Ashley Ave,DCRI Room 509, Charleston, SC 29425 USA.; Won, J (corresponding author), Med Univ South Carolina, Dept Pathol & Lab Med, 173 Ashley Ave,DCRI Room 510, Charleston, SC 29425 USA.
EM singhi@musc.edu; wonj@musc.edu
RI Singh, Ashok/HGF-2506-2022
FU NIH HHS [NS037766] Funding Source: Medline; BLRD VA [I01 BX003401]
   Funding Source: Medline
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NR 55
TC 18
Z9 20
U1 0
U2 8
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0892-6638
EI 1530-6860
J9 FASEB J
JI Faseb J.
PD MAY
PY 2020
VL 34
IS 5
BP 6808
EP 6823
DI 10.1096/fj.201901318R
PG 16
WC Biochemistry & Molecular Biology; Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA LL1OX
UT WOS:000531325500056
PM 32239698
DA 2025-06-11
ER

PT J
AU Cordero-Herrera, I
   Martín, MA
   Goya, L
   Ramos, S
AF Cordero-Herrera, Isabel
   Angeles Martin, Maria
   Goya, Luis
   Ramos, Sonia
TI Cocoa intake ameliorates hepatic oxidative stress in young Zucker
   diabetic fatty rats
SO FOOD RESEARCH INTERNATIONAL
LA English
DT Article
DE Antioxidant/detoxifying defence system; Cocoa; Glucose tolerance;
   Insulin resistance; Oxidative stress; Type 2 diabetic ZDF rats
ID INSULIN-RESISTANCE; ANTIOXIDANT ENZYMES; METABOLIC SYNDROME; GLUCOSE;
   GLUTATHIONE; LIVER; RICH; SUPPLEMENTATION; MODULATION; MECHANISMS
AB Chronic hyperglycemia in diabetes is associated with oxidative stress-mediated tissue damage. The present study is aimed to explore the role of a cocoa-enriched diet in ameliorating the oxidative stress-induced damage in the liver of young type 2 diabetic Zucker diabetic fatty (ZDF) rats. Male ZDF rats were fed a control or cocoa-rich diet (10%), and Zucker Lean (ZL) animals received the control diet. ZDF rats fed with cocoa (ZDF-Ca) decreased body weight gain, glucose and insulin levels, and improved glucose tolerance and insulin resistance. Cocoa diet further reduced reactive oxygen species (ROS) levels and carbonyl content in the liver of ZDF animals. The diminished activity of superoxide dismutase (SOD) and the enhanced activity of heme oxygenase (HO-1) in ZDF-C were returned to ZL values upon cocoa administration. Cocoa did not restore the decreased glutathione-Stransferase (GST) activity in both ZDF groups in comparison to ZL rats. Glutathione (GSH) content and activities of glutathione peroxidase (GPx), glutathione reductase (GR) and catalase (CAT) remained unaltered among all animal groups. Moreover, cocoa-rich diet suppressed total and phosphorylated nuclear factor erythroidderived 2-like 2 (Nrf2), as well as p65-nuclear factor-kappaB (NF-B) enhanced levels observed in ZDF rats. The results indicate that cocoa protects the hepatocytes by improving the antioxidant competence in the liver of young type 2 diabetic ZDF rats. (C) 2015 Elsevier Ltd. All rights reserved.
C1 [Cordero-Herrera, Isabel; Angeles Martin, Maria; Goya, Luis; Ramos, Sonia] CSIC, Inst Food Sci & Technol & Nutr ICTAN, Dept Metab & Nutr, Madrid 28040, Spain.
   [Angeles Martin, Maria] ISCIII, Ctr Invest Biomed Red Diabet & Enfermedades Metab, Madrid, Spain.
C3 Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Instituto
   de Ciencia y Tecnologia de Alimentos y Nutricion (ICTAN); Instituto de
   Salud Carlos III; CIBER - Centro de Investigacion Biomedica en Red;
   CIBERDEM
RP Ramos, S (corresponding author), CSIC, Inst Food Sci & Technol & Nutr ICTAN, Dept Metab & Nutr, Jose Antonio Novais 10,Ciudad Univ, Madrid 28040, Spain.
EM s.ramos@ictan.csic.es
RI Santos, M.A./L-9005-2014; Martin, Maria Angeles/C-5768-2014; Ramos,
   Sonia/K-4594-2012; Goya, Luis/H-5735-2012
OI Martin, Maria Angeles/0000-0001-8173-4521; Ramos,
   Sonia/0000-0003-2649-2616; Goya, Luis/0000-0001-9449-6200
FU Spanish Ministry of Science and Innovation (MICINN) [AGL2010-17579,
   CSD2007-00063]
FX This work was supported by the grants AGL2010-17579 and CSD2007-00063
   from the Spanish Ministry of Science and Innovation (MICINN). I.
   Cordero-Herrera is a fellow of the FPI Predoctoral Program of MICINN.
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NR 46
TC 25
Z9 28
U1 0
U2 20
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0963-9969
EI 1873-7145
J9 FOOD RES INT
JI Food Res. Int.
PD MAR
PY 2015
VL 69
BP 194
EP 201
DI 10.1016/j.foodres.2014.12.039
PG 8
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA CE9OT
UT WOS:000352174000024
DA 2025-06-11
ER

PT J
AU Kan, J
   Hui, YY
   Xie, WJ
   Chen, CC
   Liu, Y
   Jin, CH
AF Kan, Juan
   Hui, Yaoyao
   Xie, Wangjing
   Chen, Cuicui
   Liu, Ying
   Jin, ChangHai
TI Lily bulbs' polyphenols extract ameliorates oxidative stress and lipid
   accumulation in vitro and in vivo
SO JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
LA English
DT Article
DE lily bulbs; polyphenols; oxidative stress; lipid accumulation; high fat
   diet
ID FATTY LIVER-DISEASE; ACID-INDUCED STEATOSIS; GASTROINTESTINAL DIGESTION;
   LILIUM-LANCIFOLIUM; GUT MICROBIOTA; ANTIOXIDANT; MODEL; MICE; RAT;
   INFLAMMATION
AB BACKGROUND Polyphenols have the potential to reduce the risk of many metabolic disorders. Lily bulbs are rich in polyphenols; however, their effects on lipid metabolism remain unclear. This study aimed to explore the effects of lily bulbs' polyphenols (LBPs) on oxidative stress and lipid metabolism.
   RESULTS A total of 14 polyphenolic compounds in LBPs were identified by high-performance liquid chromatography equipped with diode-array detection mass spectrometry. Total phenolic compound in LBPs was 53.76 +/- 1.12 g kg(-1) dry weight. In cellular experiments, LBPs attenuated the disruption of mitochondrial membrane potential, impeded reactive oxygen species production, alleviated oxidative stress, and reduced lipid accumulation in oleic acid induced HepG2 cells. In in vivo studies, LBPs significantly inhibited body weight gain, reduced lipid levels in serum and liver, and improved oxidative damage in a dose-dependent manner in mice fed a high-fat diet. Moreover, LBPs ameliorated hepatic steatosis and suppressed the expression of hepatic-lipogenesis-related genes (SREBP-1c, FAS, ACC1, and SCD-1) and promoted lipolysis genes (SRB1 and HL) and lipid oxidation genes (PPAR alpha and CPT-1) in mice fed a high-fat diet.
   CONCLUSION It was concluded that LBPs are a potential complementary therapeutic alternative in the development of functional foods to curb obesity and obesity-related diseases, such as metabolic syndrome. (c) 2021 Society of Chemical Industry
C1 [Kan, Juan; Hui, Yaoyao; Xie, Wangjing; Chen, Cuicui; Liu, Ying; Jin, ChangHai] Yangzhou Univ, Coll Food Sci & Engn, Yangzhou 225127, Jiangsu, Peoples R China.
C3 Yangzhou University
RP Jin, CH (corresponding author), Yangzhou Univ, Coll Food Sci & Engn, Yangzhou 225127, Jiangsu, Peoples R China.
EM chjin@yzu.edu.cn
RI Kan, Juan/LMP-9394-2024
OI Kan, Juan/0000-0002-4085-9237
FU National Natural Science Foundation of China [31871803]; Jiangsu-UK
   World-Class University Consortium Programme
FX This work was supported by National Natural Science Foundation of China
   (no. 31871803) and the Jiangsu-UK World-Class University Consortium
   Programme.
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NR 55
TC 6
Z9 7
U1 5
U2 84
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-5142
EI 1097-0010
J9 J SCI FOOD AGR
JI J. Sci. Food Agric.
PD SEP
PY 2021
VL 101
IS 12
BP 5038
EP 5048
DI 10.1002/jsfa.11148
EA FEB 2021
PG 11
WC Agriculture, Multidisciplinary; Chemistry, Applied; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture; Chemistry; Food Science & Technology
GA TU9ZU
UT WOS:000620388800001
PM 33570774
DA 2025-06-11
ER

PT J
AU Herranz-López, M
   Olivares-Vicente, M
   Encinar, JA
   Barrajón-Catalán, E
   Segura-Carretero, A
   Joven, J
   Micol, V
AF Herranz-Lopez, Maria
   Olivares-Vicente, Marilo
   Encinar, Jose Antonio
   Barrajon-Catalan, Enrique
   Segura-Carretero, Antonio
   Joven, Jorge
   Micol, Vicente
TI Multi-Targeted Molecular Effects of Hibiscus sabdariffa
   Polyphenols: An Opportunity for a Global Approach to Obesity
SO NUTRIENTS
LA English
DT Review
DE antioxidants; dietary supplementation; obesity; epigenetics; metabolic
   stress; polyphenols; metabolites; virtual screening; Hibiscus sabdariffa
ID ACTIVATED PROTEIN-KINASE; MONOCYTE CHEMOATTRACTANT PROTEIN-1;
   PLANT-DERIVED POLYPHENOLS; OXIDATIVE STRESS; METABOLIC SYNDROME;
   ANTIOXIDANT CAPACITY; DIETARY POLYPHENOLS; ETHANOLIC EXTRACT; AQUEOUS
   EXTRACT; BLOOD-PRESSURE
AB Improper diet can alter gene expression by breaking the energy balance equation and changing metabolic and oxidative stress biomarkers, which can result in the development of obesity-related metabolic disorders. The pleiotropic effects of dietary plant polyphenols are capable of counteracting by modulating different key molecular targets at the cell, as well as through epigenetic modifications. Hibiscus sabdariffa (HS)-derived polyphenols are known to ameliorate various obesity-related conditions. Recent evidence leads to propose the complex nature of the underlying mechanism of action. This multi-targeted mechanism includes the regulation of energy metabolism, oxidative stress and inflammatory pathways, transcription factors, hormones and peptides, digestive enzymes, as well as epigenetic modifications. This article reviews the accumulated evidence on the multiple anti-obesity effects of HS polyphenols in cell and animal models, as well as in humans, and its putative molecular targets. In silico studies reveal the capacity of several HS polyphenols to act as putative ligands for different digestive and metabolic enzymes, which may also deserve further attention. Therefore, a global approach including integrated and networked omics techniques, virtual screening and epigenetic analysis is necessary to fully understand the molecular mechanisms of HS polyphenols and metabolites involved, as well as their possible implications in the design of safe and effective polyphenolic formulations for obesity.
C1 [Herranz-Lopez, Maria; Olivares-Vicente, Marilo; Encinar, Jose Antonio; Barrajon-Catalan, Enrique; Micol, Vicente] UMH, IBMC, Edificio Torregaitan, Elche 03202, Spain.
   [Segura-Carretero, Antonio] Univ Granada, Dept Analyt Chem, Avda Fuentenueva S-N, E-18071 Granada, Spain.
   [Segura-Carretero, Antonio] PTS Granada, Res & Dev Funct Food Ctr CIDAF, Avda Conocimiento S-N,Edificio BioReg, Granada 18016, Spain.
   [Joven, Jorge] Univ Rovira & Virgili, Inst Invest Sanitaria Pere Virgili, Hosp Univ St Joan, Unitat Recerca Biomed, E-43201 Reus, Spain.
   [Micol, Vicente] ISCIII, CIBERobn, CIBER Fisiopatol Obesidad & Nutr CB12 03 30038, Palma De Mallorca 07122, Spain.
C3 Universidad Miguel Hernandez de Elche; University of Granada;
   Universitat Rovira i Virgili; Institut d'Investigacio Sanitaria Pere
   Virgili (IISPV); CIBER - Centro de Investigacion Biomedica en Red;
   CIBEROBN; Instituto de Salud Carlos III
RP Micol, V (corresponding author), UMH, IBMC, Edificio Torregaitan, Elche 03202, Spain.; Micol, V (corresponding author), ISCIII, CIBERobn, CIBER Fisiopatol Obesidad & Nutr CB12 03 30038, Palma De Mallorca 07122, Spain.
EM mherranz@umh.es; maria.olivares@umh.es; jant.encinar@umh.es;
   e.barrajon@umh.es; ansegura@ugr.es; jjoven@grupsagessa.com;
   vmicol@umh.es
RI Herranz-Lopez, Maria/AAB-1933-2020; Micol, Vicente/K-6841-2014; Encinar,
   José/AAE-9141-2020; Joven, Jorge/B-3360-2016; segura Carretero,
   Antonio/B-6867-2014; Barrajon-Catalan, Enrique/C-2884-2013; Encinar,
   Jose Antonio/F-2946-2013
OI Joven, Jorge/0000-0003-2749-4541; segura Carretero,
   Antonio/0000-0002-5564-5338; Micol, Vicente/0000-0001-8089-0696;
   Herranz-Lopez, Maria/0000-0002-1819-7978; Olivares-Vicente,
   Marilo/0000-0002-2792-9181; Barrajon-Catalan,
   Enrique/0000-0001-8113-0795; Encinar, Jose Antonio/0000-0002-7219-3863
FU Spanish Ministry of Science and Innovation [AGL2011-29857-C03-03,
   IDI-20120751]; Spanish Ministry of Economy and Competitiveness (MINECO)
   [AGL2015-67995-C3-1-R, AGL2015-67995-C3-2-R, AGL2015-67995-C3-3-R];
   Generalitat Valenciana [PROMETEO/2012/007, PROMETEO/2016/006,
   ACOMP/2013/093, ACIF/2010/162, ACIF/2015/158, ACIF/2016/230]; CIBER
   [CB12/03/30038]
FX Some of the investigations described in this review have been partially
   or fully supported by competitive public grants from the following
   institutions: AGL2011-29857-C03-03 and IDI-20120751 grants (Spanish
   Ministry of Science and Innovation); projects AGL2015-67995-C3-1-R,
   AGL2015-67995-C3-2-R and AGL2015-67995-C3-3-R from the Spanish Ministry
   of Economy and Competitiveness (MINECO); and PROMETEO/2012/007,
   PROMETEO/2016/006, ACOMP/2013/093, ACIF/2010/162, ACIF/2015/158 and
   ACIF/2016/230 grants from Generalitat Valenciana and CIBER
   (CB12/03/30038, Fisiopatologia de la Obesidad y la Nutricion, CIBERobn,
   Instituto de Salud Carlos III, Spain). We are grateful to Research,
   Technological Innovation and Supercomputing Center of Extremadura
   (CenitS) for allowing us to use their supercomputing facilities
   (LUSITANIA II).
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NR 120
TC 54
Z9 54
U1 0
U2 20
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD AUG
PY 2017
VL 9
IS 8
AR 907
DI 10.3390/nu9080907
PG 26
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA FF1VU
UT WOS:000408688100114
PM 28825642
OA Green Submitted, gold, Green Published
DA 2025-06-11
ER

PT J
AU Colak, GA
   Kiziltan, G
AF Colak, Gozde Aritici
   Kiziltan, Gul
TI The effect of nutrition theraphy on oxidative stress, inflammation,
   glycemic control in type 2 diabetes patients
SO PROGRESS IN NUTRITION
LA English
DT Article
DE glycemic control; inflammation; oxidative stress; medical nutrition
   therapy; Type 2 diabetes
ID METABOLIC SYNDROME; MARKERS
AB Aims: Type 2 diabetes mellitus is a metabolism disease which is seen frequently among adult population in Turkey. The aim of this study was to determine the medical nutrition theraphy effect on oxidative stress, inflammation, glycemic control in type 2 diabetes patients. Methods: An interventional study was carried on 35 type 2 diabetes ages between 20-65 years old at the Department of Endocrinology of Baskent University Istanbul Hospital in 2015. In 3 month period a personal nutrition theraphy was applied. Biochemical parameters, anthropometric measurements and body analysis were also determined. The three day food consumption and biochemical parameters were requested at the beginning and at the end of the study. Results: When the impact of the blood values of the new medical nutrition theraphy which the patients practiced during the first visit and the follow up visit were compared; it was seen that there was a significant decrease on fasting plasma glucose, fasting insulin, HbA1c, CRP, TG and MDA values (p<0.05). The mean diabetic age of the patients was 7.63 +/- 6.22 years. When diabetic age of the patients was increased, there was a positive correlation between the fasting plasma glucose and HbA1c values (p<0.05). Conclusions: Type 2 diabetes patients were evaluated 3 month of medical nutrition theraphy and it was seen that the personal medical nutritional theraphy contributed to providing glisemic control and decreasing oxidative stress and inflammation.
C1 [Colak, Gozde Aritici] Acibadem Mehmet Ali Aydinlar Univ, Hlth Sci Fac, Dept Nutr & Dietet, Icerenkoy Mahallesi Kayisdagi Caddesi 32, Istanbul, Turkey.
   [Kiziltan, Gul] Baskent Univ, Hlth Sci Fac, Dept Nutr & Dietet, Ankara, Turkey.
C3 Acibadem University; Baskent University
RP Colak, GA (corresponding author), Acibadem Mehmet Ali Aydinlar Univ, Hlth Sci Fac, Dept Nutr & Dietet, Icerenkoy Mahallesi Kayisdagi Caddesi 32, Istanbul, Turkey.
EM gozde.aritici@acibadem.edu.tr
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NR 23
TC 0
Z9 0
U1 0
U2 16
PU MATTIOLI 1885
PI FIDENZA
PA VIA DELLA LODESANA 649-SX, FIDENZA, 43046 PR, ITALY
SN 1129-8723
J9 PROG NUTR
JI Prog. Nutr.
PD DEC
PY 2019
VL 21
IS 4
BP 804
EP 812
DI 10.23751/pn.v21i4.7478
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA JX8YQ
UT WOS:000504014800010
DA 2025-06-11
ER

PT J
AU Khan, DA
   Qayyum, S
AF Khan, Dilshad Ahmed
   Qayyum, Shazia
TI EVALUATION OF CARDIAC RISK BY OXIDATIVE STRESS AND INFLAMMATORY MARKERS
   IN DIABETIC PATIENTS
SO PAKISTAN JOURNAL OF MEDICAL SCIENCES
LA English
DT Article
DE Diabetes mellitus; Gamma glutamyltransferase; C-reactive protein;
   Nitrate; Total cholesterol; Oxidative stress
ID GAMMA-GLUTAMYL-TRANSFERASE; C-REACTIVE PROTEIN; CARDIOVASCULAR-DISEASE;
   NITRIC-OXIDE; METABOLIC SYNDROME; MELLITUS; POPULATION; HEALTH; WOMEN;
   MEN
AB Objectives: To evaluate the diabetic patients for cardiac risk by measuring oxidative stress and inflammatory markers in relation with glycaemic control.
   Methodology: A total of 140 subjects were included in this case-control study, comprising of 70 diabetic patients with coronary heart disease (CHD) and an equal number, age and sex matched controls. The patients were non-alcoholic and had age >40years, BMI < 30 kg/m(2) and glycated hemoglobin (HbA1c) 7-10%. Serum total cholesterol (TC) and gamma glutamyltransferase (GGT) were analyzed on selectra-E auto analyzer. Serum nitrate was measured at 540nm on ELISA. HbA1c on was analyzed by using Human kit. Serum high sensitivity C-reactive protein (hS-CRP) was analyzed on immulite 1000.
   Results: Patients mean age was 51 (range 40-73) years. Diabetic patients had significantly elevated median of HbA1c (7.9 vs 4.9), hS CRP (6.0 vs 2.12), TC (5.95 vs 4.45), nitrate (19.20vs 10.70) and GGT (29.50 vs 22.50) as compared to controls (p< 0.001). HbA1c showed a positive correlation (p <0.001) with hS-CRP (r=0.49), TC (r=0.69), nitrate (r=0.41) and GGT (r=0.30).
   Conclusion: Oxidative stress and inflammatory markers should be used in addition to HbA1c for assessment of increased cardiac risk in un-controlled diabetic patients because of accelerated atherosclerosis due to free radical injury.
C1 [Khan, Dilshad Ahmed] Natl Univ Sci & Technol, Dept Pathol, Army Med Coll, Rawalpindi, Pakistan.
   [Qayyum, Shazia] Riphah Univ, Islam Int Medial Coll, Rawalpindi, Pakistan.
C3 National University of Sciences & Technology - Pakistan
RP Khan, DA (corresponding author), Natl Univ Sci & Technol, Dept Pathol, Army Med Coll, Abid Majeed Rd, Rawalpindi, Pakistan.
EM dilshad56@yahoo.com
FU Amcolians Alumni Association (AAA) C/O Army Medical College,
   Rawalpindi-Pakistan
FX This study was supported by Amcolians Alumni Association (AAA) C/O Army
   Medical College, Rawalpindi-Pakistan.
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NR 33
TC 5
Z9 5
U1 0
U2 0
PU PROFESSIONAL MEDICAL PUBLICATIONS
PI SADDAR
PA PANORAMA CENTRE, RM 522, 5TH FLOOR, BLDG 2, RAJA GHAZANFAR ALI RD, PO
   BOX 8766, SADDAR, KARACHI 00000, PAKISTAN
SN 1682-024X
J9 PAK J MED SCI
JI Pak. J. Med. Sci.
PD OCT-DEC
PY 2009
VL 25
IS 5
BP 776
EP 781
PN 1
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 521KH
UT WOS:000271919700016
DA 2025-06-11
ER

PT J
AU Dludla, PV
   Mazibuko-Mbeje, SE
   Nyambuya, TM
   Mxinwa, V
   Tiano, L
   Marcheggiani, F
   Cirilli, I
   Louw, J
   Nkambule, BB
AF Dludla, Phiwayinkosi V.
   Mazibuko-Mbeje, Sithandiwe E.
   Nyambuya, Tawanda M.
   Mxinwa, Vuyolwethu
   Tiano, Luca
   Marcheggiani, Fabio
   Cirilli, Ilenia
   Louw, Johan
   Nkambule, Bongani B.
TI The beneficial effects of N-acetyl cysteine (NAC) against obesity
   associated complications: A systematic review of pre-clinical studies
SO PHARMACOLOGICAL RESEARCH
LA English
DT Article
DE N-acetyl cysteine; Therapeutic target; Obesity; Metabolic complications;
   Inflammation; Oxidative stress
ID PLASMINOGEN-ACTIVATOR INHIBITOR-1; INDUCED INSULIN-RESISTANCE; OXIDATIVE
   STRESS; 3T3-L1 ADIPOCYTES; ADIPOSE-TISSUE; DOWN-REGULATION; REGULATE
   MCP-1; STROMAL CELLS; STEM-CELLS; HIGH-FAT
AB Excessive adiposity in an obese state is known to drive the onset of metabolic dysregulations, mostly involving chronic immune activation and oxidative stress. Prolonged inflammation and oxidative stress have been linked to impaired adipose tissue function and the development of the metabolic syndrome. Currently available therapies offer minimal prophylactic effects, while substantial experimental evidence supports the ameliorative effects of N-acetylcysteine (NAC) against various metabolic complications associated with obesity. The current review provides a comprehensive synthesis of studies published in major search engines such as PubMed, Cochrane library, Embase, and Google Scholar assessing the therapeutic effect of NAC against obesity associated complications. Overwhelming literature included in this review supports the ameliorative effects of NAC against such complications in both in vitro and in vivo models of obesity. In addition to attenuating an abnormal pro inflammatory response and limiting mddative damage, NAC could inhibit lipid accumulation by targeting adipogenic transcription factors such as peroxisome proliferator-activated receptor gamma (PPAR gamma) and CCAAT/enhancer binding protein beta (C/EBP beta), and improve insulin sensitivity through augmenting phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT) pathway. Although necessary evidence informing on its optimal dose and its comparative effect with other well-studied pharmacological compounds is demonstrated, it is clear that future investigations are required to confirm the therapeutic effect of NAC in obese human subjects.
C1 [Dludla, Phiwayinkosi V.; Tiano, Luca; Marcheggiani, Fabio; Cirilli, Ilenia] Polytech Univ Marche, Dept Life & Environm Sci, I-60131 Ancona, Italy.
   [Dludla, Phiwayinkosi V.; Mazibuko-Mbeje, Sithandiwe E.; Louw, Johan] South African Med Res Council, Biomed Res & Innovat Platform, ZA-7505 Tygerberg, South Africa.
   [Mazibuko-Mbeje, Sithandiwe E.] Stellenbosch Univ, Fac Hlth Sci, Div Med Physiol, ZA-7505 Tygerberg, South Africa.
   [Nyambuya, Tawanda M.; Mxinwa, Vuyolwethu; Nkambule, Bongani B.] Univ KwaZulu Natal, Coll Hlth Sci, Sch Lab Med & Med Sci, ZA-4000 Durban, South Africa.
   [Louw, Johan] Univ Zululand, Dept Biochem & Microbiol, ZA-3886 Kwa Dlangezwa, South Africa.
   [Nyambuya, Tawanda M.] Namibia Univ Sci & Technol, Fac Hlth & Appl Sci, Dept Hlth Sci, Windhoek 9000, Namibia.
C3 Marche Polytechnic University; South African Medical Research Council;
   Stellenbosch University; University of Kwazulu Natal; University of
   Zululand; Namibia University of Science & Technology
RP Dludla, PV (corresponding author), Polytech Univ Marche, Dept Life & Environm Sci, I-60131 Ancona, Italy.
EM pdludla@mrc.ac.za
RI Tiano, Luca/ABC-2341-2020; Mazibuko-Mbeje, Sithandiwe/HPG-1119-2023;
   Nyambuya, Tawanda Maurice/GLU-4124-2022; Nkambule, Bongani/ABD-7943-2022
OI Nyambuya, Tawanda Maurice/0000-0002-3288-9524; Nkambule,
   Bongani/0000-0001-8846-1992; Mxinwa, Vuyolwethu/0000-0002-7680-4406;
   Louw, Johan/0000-0002-9023-1659; Dludla,
   Phiwayinkosi/0000-0001-5965-3610; Cirilli, Ilenia/0000-0001-6916-5426
FU Biomedical Research and Innovation Platform of the South African Medical
   Research Council (SAMRC); National Research Foundation [:117829];
   Research Capacity Development Division of the SAMRC
FX This work was supported in part by the Biomedical Research and
   Innovation Platform of the South African Medical Research Council
   (SAMRC) baseline funding and the National Research Foundation (Grant
   number:117829). While, PV Dludla was also partially supported as a
   Post-Doctoral Fellow by funding from Research Capacity Development
   Division of the SAMRC. The grant holders acknowledge that opinions,
   findings, and conclusions or recommendations expressed in any
   publication generated by the SAMRC or National Research Foundation
   supported research are those of the authors, and that the SAMRC accepts
   no liability whatsoever in this regard.
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NR 128
TC 39
Z9 40
U1 1
U2 9
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 1043-6618
EI 1096-1186
J9 PHARMACOL RES
JI Pharmacol. Res.
PD AUG
PY 2019
VL 146
AR 104332
DI 10.1016/j.phrs.2019.104332
PG 14
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA IS6FS
UT WOS:000482248300016
PM 31254666
DA 2025-06-11
ER

PT J
AU Lee, J
   Ma, K
   Moulik, M
   Yechoor, V
AF Lee, J.
   Ma, K.
   Moulik, M.
   Yechoor, V.
TI Untimely oxidative stress in β-cells leads to diabetes - Role of
   circadian clock in β-cell function
SO FREE RADICAL BIOLOGY AND MEDICINE
LA English
DT Article; Proceedings Paper
CT Joint Conference of the Physiological-Society and the
   American-Physiological-Society
CY 2016
CL Dublin, IRELAND
SP Physiol Soc, Amer Physiol Soc
DE Circadian clock; Islet; beta-cell; Insulin; Oxidative stress; Diabetes;
   Bmal1; Nrf2
ID REV-ERB-ALPHA; GENE-EXPRESSION; GLUCOSE-HOMEOSTASIS; METABOLIC SYNDROME;
   INSULIN-SECRETION; PERIPHERAL CLOCKS; BMAL1; MOUSE; ADAPTATION;
   COMPONENT
AB Diabetes results from a loss of beta-cell function. With the number of people with diabetes reaching epidemic proportions globally, understanding mechanisms that are contributing to this increasing prevalence is critical. One such factor has been circadian disruption, with shift-work, light pollution, jet-lag, increased screen time, all acting as potential contributory factors. Though circadian disruption has been epidemiologically associated with diabetes and other metabolic disorders for many decades, it is only recently that there has been a better understanding of the underlying molecular mechanisms. Experimental circadian disruption, via manipulation of environmental or genetic factors using gene-deletion mouse models, has demonstrated the importance of circadian rhythms in whole body metabolism. Genetic disruption of core clock genes, specifically in the beta-cells in mice, have, now demonstrated the importance of the intrinsic beta-cell clock in regulating function. Recent work has also shown the interaction of the circadian clock and enhancers in beta-cells, indicating a highly integrated regulation of transcription and cellular function by the circadian clock. Disruption of either the whole body or only the beta-cell clock leads to significant impairment of mitochondrial function, uncoupling, impaired vesicular transport, oxidative stress in beta-cells and finally impaired glucose-stimulated insulin secretion and diabetes. In this review, we explore the role of the circadian clock in mitigating oxidative stress and preserving beta-cell function.
C1 [Lee, J.; Yechoor, V.] Univ Pittsburgh, Diabet & Beta Cell Biol Ctr, Dept Med, Div Endocrinol Diabet & Metab, 200 Lothrop,BST-1058W, Pittsburgh, PA 15261 USA.
   [Ma, K.] City Hope Natl Med Ctr, Diabet & Metab Res Inst, Duarte, CA USA.
   [Moulik, M.] Childrens Hosp Pittsburgh, Dept Pediat, Div Cardiol, Pittsburgh, PA 15213 USA.
   [Moulik, M.] Univ Pittsburgh, Pittsburgh, PA USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE); University
   of Pittsburgh; City of Hope; Pennsylvania Commonwealth System of Higher
   Education (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth
   System of Higher Education (PCSHE); University of Pittsburgh
RP Yechoor, V (corresponding author), Univ Pittsburgh, Diabet & Beta Cell Biol Ctr, Dept Med, Div Endocrinol Diabet & Metab, 200 Lothrop,BST-1058W, Pittsburgh, PA 15261 USA.
EM yechoorv@pitt.edu
RI Yechoor, Vijay/AAX-3244-2021
FU NIH [R01DK097160, R01DK112794]; American Diabetes Association
   [7-12-BS-210]
FX The work was supported by grants to VY from NIH: R01DK097160; American
   Diabetes Association: 7-12-BS-210; to KM from NIH: R01DK112794.
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NR 87
TC 29
Z9 34
U1 0
U2 17
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0891-5849
EI 1873-4596
J9 FREE RADICAL BIO MED
JI Free Radic. Biol. Med.
PD MAY 1
PY 2018
VL 119
BP 69
EP 74
DI 10.1016/j.freeradbiomed.2018.02.022
PG 6
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA GD2VY
UT WOS:000430362700009
PM 29458148
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Damasceno, DC
   Sinzato, YK
   Bueno, A
   Dallaqua, B
   Lima, PH
   Calderon, IMP
   Rudge, MVC
   Campos, KE
AF Damasceno, Debora C.
   Sinzato, Yuri K.
   Bueno, Aline
   Dallaqua, Bruna
   Lima, Paula H.
   Calderon, Iracema M. P.
   Rudge, Marilza V. C.
   Campos, Kleber E.
TI Metabolic Profile and Genotoxicity in Obese Rats Exposed to Cigarette
   Smoke
SO OBESITY
LA English
DT Article
ID OXIDATIVE STRESS; DNA-DAMAGE; INFLAMMATION; GROWTH; PLASMA; IMPACT
AB Objective: Experimental studies have shown that exposure to cigarette smoke has negative effects on lipid metabolism and oxidative stress status. Cigarette smoke exposure in nonpregnant and pregnant rats causes significant genotoxicity (DNA damage). However, no previous studies have directly evaluated the effects of obesity or the association between obesity and cigarette smoke exposure on genotoxicity. Therefore, the aim of the present investigation was to evaluate DNA damage levels, oxidative stress status and lipid profiles in obese Wistar rats exposed to cigarette smoke.
   Design and Methods: Female rats subcutaneously (sc) received a monosodium glutamate solution or vehicle (control) during the neonatal period to induce obesity. The rats were randomly distributed into three experimental groups: control, obese exposed to filtered air, and obese exposed to tobacco cigarette smoke. After a 2-month exposure period, the rats were anesthetized and killed to obtain blood samples for genotoxicity, lipid profile, and oxidative stress status analyses.
   Results: The obese rats exposed to tobacco cigarette smoke presented higher DNA damage, triglycerides, total cholesterol, free fatty acids, VLDL-c, HDL-c, and LDL-c levels compared to control and obese rats exposed to filtered air. Both obese groups showed reduced SOD activity. These results showed that cigarette smoke enhanced the effects of obesity.
   Conclusion: In conclusion, the association between obesity and cigarette smoke exposure exacerbated the genotoxicity, negatively impacted the biochemical profile and antioxidant defenses and caused early glucose intolerance. Thus, the changes caused by cigarette smoke exposure can trigger the earlier onset of metabolic disorders associated with obesity, such as diabetes and metabolic syndrome.
C1 [Damasceno, Debora C.; Sinzato, Yuri K.; Bueno, Aline; Dallaqua, Bruna; Lima, Paula H.; Calderon, Iracema M. P.; Rudge, Marilza V. C.; Campos, Kleber E.] Univ Estadual Paulista, UNESP, Dept Gynecol & Obstet, Lab Expt Res Gynecol & Obstet,Botucatu Med Sch, Sao Paulo, SP, Brazil.
   [Campos, Kleber E.] Mato Grosso Fed Univ UFMT, Univ Ctr Araguaia, Dept Physiol, Inst Biol & Hlth Sci, Barra Do Garcas, Mato Grosso, Brazil.
C3 Universidade Estadual Paulista; Universidade Federal de Mato Grosso do
   Sul
RP Damasceno, DC (corresponding author), Univ Estadual Paulista, UNESP, Dept Gynecol & Obstet, Lab Expt Res Gynecol & Obstet,Botucatu Med Sch, Sao Paulo, SP, Brazil.
EM damascenofmb@gmail.com
RI Campos, Kleber/D-4483-2014; Bueno, Aline/D-1575-2012; Sinzato,
   Yuri/E-8626-2019; Calderon, Iracema/W-4336-2019; Rudge,
   Marilza/S-9057-2018; Lima, Paula/H-3559-2015; DALLAQUA,
   BRUNA/C-7288-2012; Damasceno, Debora Cristina/C-7234-2012; Calderon,
   Iracema/C-8136-2012; Vieira Cunha Rudge, Marilza/C-8338-2012
OI Damasceno, Debora Cristina/0000-0002-7003-9643; Ortiz Lima, Paula
   Helena/0000-0002-0631-8074; Calderon, Iracema/0000-0003-4761-4336;
   Vieira Cunha Rudge, Marilza/0000-0002-9227-832X; Sinzato,
   Yuri/0000-0002-2973-1099
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NR 32
TC 20
Z9 21
U1 0
U2 11
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1930-7381
EI 1930-739X
J9 OBESITY
JI Obesity
PD AUG
PY 2013
VL 21
IS 8
BP 1596
EP 1601
DI 10.1002/oby.20152
PG 6
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 206LE
UT WOS:000323521500014
PM 23666719
DA 2025-06-11
ER

PT J
AU Barbagallo, M
   Dominguez, LJ
AF Barbagallo, M.
   Dominguez, L. J.
TI Magnesium and Aging
SO CURRENT PHARMACEUTICAL DESIGN
LA English
DT Review
DE Magnesium; aging; Mg deficiency; anti-aging; oxidative stress; chronic
   inflammation; diabetes; hypertension
ID C-REACTIVE PROTEIN; TYPE-2 DIABETES-MELLITUS; DIETARY MAGNESIUM;
   OXIDATIVE STRESS; INTRACELLULAR MAGNESIUM; METABOLIC SYNDROME;
   SUBSTANCE-P; INFLAMMATORY RESPONSE; BLOOD-PRESSURE; TNF-ALPHA
AB Over the past decades, the clinical relevance and biological significance of magnesium (Mg) have been documented. Deficiency in Mg, aside from having a negative impact on the energy production pathway required by mitochondria to generate ATP, also reduces the threshold antioxidant capacity of the aging organism and its resistance to free-radical damage. Mg also acts as an antioxidant against free radical damage of the mitochondria. Chronic inflammation and oxidative stress have both been identified as pathogenic factors in aging and in several age-related diseases. Chronic Mg deficiency results in excessive production of oxygen-derived free radicals and low grade inflammation. Aging is very often associated with Mg inadequacy and with increased incidence of many chronic diseases, muscle loss and sarcopenia, altered immune responses, and vascular and metabolic conditions, such as atherosclerosis, diabetes and the cardiometabolic syndrome.
   The most common cause of Mg deficit in the elderly population is dietary Mg deficiency, although secondary Mg deficit in aging may also results from many different mechanisms.
   The aim of the present manuscript is to discuss the mechanisms and consequences of the modifications of Mg metabolism with age, the difficulties in the measurement of Mg status, and to review the current evidences suggesting that age-related chronic Mg deficits may be proposed as one of the physiopathological links that may help to explain the interactions between inflammation, and oxidative stress with the aging process and many age-related diseases.
C1 [Barbagallo, M.; Dominguez, L. J.] Univ Palermo, Dept Internal Med & Emergent Pathol, Geriatr Unit, I-90133 Palermo, Italy.
C3 University of Palermo
RP Barbagallo, M (corresponding author), Viale F Scaduto 6-C, I-90144 Palermo, Italy.
EM mabar@unipa.it
RI ; BARBAGALLO, MARIO/K-4794-2017
OI dominguez, ligia j/0000-0003-1466-8610; BARBAGALLO,
   MARIO/0000-0002-1349-6530
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NR 99
TC 102
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U1 1
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PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1381-6128
EI 1873-4286
J9 CURR PHARM DESIGN
JI Curr. Pharm. Design
PD MAR
PY 2010
VL 16
IS 7
BP 832
EP 839
DI 10.2174/138161210790883679
PG 8
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 556CG
UT WOS:000274564600011
PM 20388094
DA 2025-06-11
ER

PT J
AU Geronikolou, SA
   Pavlopoulou, A
   Apaydin, MU
   Albanopoulos, K
   Cokkinos, DV
   Chrousos, G
AF Geronikolou, Styliani A.
   Pavlopoulou, Athanasia
   Apaydin, Merve Uca
   Albanopoulos, Konstantinos
   Cokkinos, Dennis V.
   Chrousos, George
TI Non-Hereditary Obesity Type Networks and New Drug Targets: An In Silico
   Approach
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE stress system/inflammation-induced obesity; stress-induced obesity;
   kisspeptin; natural products; systems epidemiology; drug discovery
ID CIRCADIAN CLOCK; ADIPOSE-TISSUE; METABOLIC SYNDROME; INNATE IMMUNITY;
   STRESS; ASSOCIATION; WEIGHT; HEALTH; BMAL1; MICE
AB Obesity, a chronic, preventable disease, has significant comorbidities that are associated with a great human and financial cost for society. The aim of the present work is to reconstruct the interactomes of non-hereditary obesity to highlight recent advances of its pathogenesis, and discover potential therapeutic targets. Obesity and biological-clock-related genes and/or gene products were extracted from the biomedical literature databases PubMed, GeneCards and OMIM. Their interactions were investigated using STRING v11.0 (a database of known and predicted physical and indirect associations among genes/proteins), and a high confidence interaction score of >0.7 was set. We also applied virtual screening to discover natural compounds targeting obesity- and circadian-clock-associated proteins. Two updated and comprehensive interactomes, the (a) stress- and (b) inflammation-induced obesidomes involving 85 and 93 gene/gene products of known and/or predicted interactions with an average node degree of 9.41 and 10.8, respectively, were produced. Moreover, 15 of these were common between the two non-hereditary entities, namely, ADIPOQ, ADRB2/3, CCK, CRH, CXCL8, FOS, GCG, GNRH1, IGF1, INS, LEP, MC4R, NPY and POMC, while phelligridin E, a natural product, may function as a potent FOX1-DBD interaction blocker. Molecular networks may contribute to the understanding of the integrated regulation of energy balance/obesity pathogenesis and may associate chronopharmacology schemes with natural products.
C1 [Geronikolou, Styliani A.; Cokkinos, Dennis V.; Chrousos, George] Acad Athens, Biomed Res Fdn, Clin Translat Res & Expt Surg Ctr, 4 Soranou Ephessiou Str, Athens 11527, Greece.
   [Geronikolou, Styliani A.; Chrousos, George] Natl & Kapodistrian Univ Athens, Univ Res Inst Maternal & Child Hlth & Precis Med, Med Sch, Levadias 8, Athens 11527, Greece.
   [Pavlopoulou, Athanasia; Apaydin, Merve Uca] Izmir Biomed & Genome Ctr IBG, TR-35340 Izmir, Turkiye.
   [Pavlopoulou, Athanasia; Apaydin, Merve Uca] Dokuz Eylul Univ, Izmir Int Biomed & Genome Inst, Genom & Mol Biotechnol Dept, TR-35340 Izmir, Turkiye.
   [Albanopoulos, Konstantinos] Iaso Gen Hosp, Athens 15562, Greece.
C3 Academy of Athens; National & Kapodistrian University of Athens; Izmir
   Biomedicine & Genome Center; Dokuz Eylul University
RP Geronikolou, SA (corresponding author), Acad Athens, Biomed Res Fdn, Clin Translat Res & Expt Surg Ctr, 4 Soranou Ephessiou Str, Athens 11527, Greece.; Geronikolou, SA (corresponding author), Natl & Kapodistrian Univ Athens, Univ Res Inst Maternal & Child Hlth & Precis Med, Med Sch, Levadias 8, Athens 11527, Greece.
EM sgeronik@bioacademy.gr; athanasia.pavlopoulou@deu.edu.tr;
   albanopoulos_kostis@yahoo.gr; dcokkinos@bioacademy.gr;
   chrousosge@med.uoa.gr
RI Chrousos, George/G-8702-2011; Geronikolou, Styliani/ABB-3278-2021;
   Pavlopoulou, Athanasia/ABB-3275-2021
OI Geronikolou, Styliani/0000-0003-1227-5274
FX We acknowledge Huseyin Gurel's kind help.
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NR 106
TC 1
Z9 1
U1 3
U2 3
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
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J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD JUL
PY 2024
VL 25
IS 14
AR 7684
DI 10.3390/ijms25147684
PG 20
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA ZX6E7
UT WOS:001278616200001
PM 39062927
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Lunder, M
   Roskar, I
   Hosek, J
   Strukelj, B
AF Lunder, Mojca
   Roskar, Irena
   Hosek, Jan
   Strukelj, Borut
TI Silver Fir (Abies alba) Extracts Inhibit Enzymes Involved in Blood
   Glucose Management and Protect against Oxidative Stress in High Glucose
   Environment
SO PLANT FOODS FOR HUMAN NUTRITION
LA English
DT Article
DE Silver fir; Digestive enzymes; Oxidative stress; Diabetes; Lignans
ID PINE BARK EXTRACT; IN-VITRO; ALPHA-GLUCOSIDASE; LIGNANS; POLYPHENOLS;
   APOPTOSIS
AB The diet rich in fruits and vegetables reduces the risk of metabolic syndrome, including diabetes development by various mechanisms of action, mainly due to the presence of polyphenolic compounds. Extracts from different conifer species are known to be a rich source of various polyphenols. In the present study we elucidated the in vitro mechanism of anti-diabetic activity of silver fir (Abies alba) wood and bark extracts and compared their activity to non-coniferous sweet chestnut wood extract and standardized maritime pine bark extract. Extracts and lignans were tested for their inhibitory activity of enzymes involved in the regulation of blood glucose in vitro. The ability of extracts to protect against oxidative stress in high glucose environment was tested on mouse myoblast cell line. Silver fir wood and bark extracts were shown to be effective inhibitors of -glucosidase, -amylase and dipeptidyl peptidase 4, three enzymes involved in the regulation of blood glucose levels. Coniferous extracts also showed protection against oxidative stress generated in high glucose environment. Lignans, particularly pinoresinol diglucoside, isolariciresinol and secolariciresinol were shown to be important contributors of antihyperglycemic activity through inhibition of dipeptidyl peptidase 4. This corroborates previously published in vivo results on blood glucose level obtained with silver fir wood extract and supports the use of silver fir wood and bark extracts as food supplements or functional foods in borderline diabetes.
C1 [Lunder, Mojca; Roskar, Irena; Strukelj, Borut] Univ Ljubljana, Fac Pharm, Askerceva 7, Ljubljana 1000, Slovenia.
   [Hosek, Jan] Univ Vet & Pharmaceut Sci Brno, Dept Mol Biol & Pharmaceut Biotechnol, Fac Pharm, Palackeho Tr 1946-1, Brno, Czech Republic.
C3 University of Ljubljana; University of Veterinary Sciences Brno
RP Lunder, M (corresponding author), Univ Ljubljana, Fac Pharm, Askerceva 7, Ljubljana 1000, Slovenia.
EM mojca.lunder@ffa.uni-lj.si
RI Hosek, Jan/B-6274-2009
OI Hosek, Jan/0000-0003-0975-1671
FU Javna Agencija za Raziskovalno Dejavnost RS [P4-0127] Funding Source:
   Medline
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BP 47
EP 53
DI 10.1007/s11130-018-0698-6
PG 7
WC Plant Sciences; Chemistry, Applied; Food Science & Technology; Nutrition
   & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Chemistry; Food Science & Technology; Nutrition &
   Dietetics
GA HP6RU
UT WOS:000461814400007
PM 30361961
DA 2025-06-11
ER

PT J
AU Ferreira-Silva, R
   Goya, TT
   Barbosa, ERF
   Durante, BG
   Araujo, CEL
   Lorenzi, G
   Ueno-Pardi, LM
AF Ferreira-Silva, Rosyvaldo
   Goya, Thiago T.
   Barbosa, Eline R. F.
   Durante, Bruno G.
   Araujo, Carlos E. L.
   Lorenzi-Filho, Geraldo
   Ueno-Pardi, Linda M.
TI Vascular Response During Mental Stress in Sedentary and Physically
   Active Patients With Obstructive Sleep Apnea
SO JOURNAL OF CLINICAL SLEEP MEDICINE
LA English
DT Article
DE forearm blood flow; forearm vascular conductance; mental stress;
   obstructive sleep apnea; physical activity
ID ENDOTHELIUM-DEPENDENT VASODILATION; CARDIOVASCULAR-DISEASE;
   NEUROVASCULAR CONTROL; METABOLIC SYNDROME; OXIDATIVE STRESS;
   DYSFUNCTION; CAPACITY; OXIDE; PRESSURE; PREVENTS
AB Study Objectives: To compare vascular function of sedentary (SED) versus physically active (ACTIVE) patients with obstructive sleep apnea (OSA) during rest and mental stress.
   Methods: Patients with untreated OSA without other comorbidities were classified into SED and ACTIVE groups according to the International Physical Activity Questionnaire. Blood pressure (BP), heart rate (HR), forearm blood flow (FBF) (plethysmography), and forearm vascular conductance (FVC = FBF /mean BP x 100) were continuously measured at rest (4 minutes) followed by 3 minutes of mental stress (Stroop Color Word Test).
   Results: We studied 40 patients with OSA (men = 24, age = 50 +/- 1 years, body mass index = 29.3 +/- 0.5 kg/m(2), apnea-hypopnea index = 39.3 +/- 4 events/h). Leisure time physical activity domain in SED (n = 19) and ACTIVE (n = 21) was 20 +/- 8 and 239 +/- 32 min/wk, (P < .05). Baseline profile and perception of stress were similar in both groups. Baseline FBF (3.5 +/- 0.2 mL/min/100 mL versus 2.4 +/- 0.14 mL/min/100 mL) and FVC (3.5 +/- 0.2 U versus 2.3 +/- 0.1 U) were significantly lower in the SED group than in the ACTIVE group, respectively (P < .05). HR and BP increased similarly during mental stress test in both groups. Changes during mental stress in FBF (0.65 +/- 0.12 versus 1.04 +/- 0.12) and FVC (0.58 +/- 0.11 versus 0.99 +/- 0.11) were significantly lower in the SED group than in the ACTIVE group, respectively (P < .05). There was a significant correlation between leisure time physical activity and FBF (r = .57, P < .05) and FVC (r = .48, P < .05) during mental stress.
   Conclusions: The vascular response among patients with OSA is influenced by the level of physical activity. A high level of physical activity may partially protect against the cardiovascular dysfunction associated with OSA.
C1 [Ferreira-Silva, Rosyvaldo; Ueno-Pardi, Linda M.] Univ Sao Paulo, Escola Artes Ciencias & Humanidades, 1000 Bairro Vila Guaraciba, BR-03828000 Sao Paulo, Brazil.
   [Goya, Thiago T.; Durante, Bruno G.; Araujo, Carlos E. L.] Univ Sao Paulo, Fac Med, Sao Paulo, SP, Brazil.
   [Barbosa, Eline R. F.; Lorenzi-Filho, Geraldo] Univ Sao Paulo, Inst Coracao, Fac Med, Div Pneumol,Hosp Clin HCFMUSP, Sao Paulo, SP, Brazil.
C3 Universidade de Sao Paulo; Universidade de Sao Paulo; Universidade de
   Sao Paulo
RP Ueno-Pardi, LM (corresponding author), Univ Sao Paulo, Escola Artes Ciencias & Humanidades, 1000 Bairro Vila Guaraciba, BR-03828000 Sao Paulo, Brazil.
EM lindabrz@hotmail.com
RI Ueno-Pardi, Linda/D-7341-2015; Silva, Rosyvaldo/AGU-3449-2022;
   Lorenzi-Filho, Geraldo/E-1062-2012
OI Ueno-Pardi, Linda Massako/0000-0003-4348-2460; Lorenzi-Filho,
   Geraldo/0000-0002-7011-7373; Ferreira Silva,
   Rosyvaldo/0000-0003-0039-679X
FU Pro-Reitoria de Pesquisa da Universidade de Sao Paulo (FAPESP)
   [2010/15064-6]; Fundacao de Amparo a Pesquisa do Estado de Sao Paulo
   (FAPESP) [2015/14795-0]; Fundacao de Amparo a Pesquisa do Estado de Sao
   Paulo (FAPESP) [15/14795-0, 10/15064-6] Funding Source: FAPESP
FX This study was supported in part by Pro-Reitoria de Pesquisa da
   Universidade de Sao Paulo (FAPESP #2010/15064-6) to Dra. Linda M. Ueno
   Pardi. Rosyvaldo F. Silva was supported by Fundacao de Amparo a Pesquisa
   do Estado de Sao Paulo (FAPESP #2015/14795-0). Thiago T. Goya was
   supported by Coordenacao de Aperfeicoamento de Pessoal de Nivel
   Superior. The authors report no conflicts of interest.
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NR 39
TC 5
Z9 5
U1 0
U2 3
PU AMER ACAD SLEEP MEDICINE
PI DARIEN
PA 2510 N FRONTAGE RD, DARIEN, IL 60561 USA
SN 1550-9389
EI 1550-9397
J9 J CLIN SLEEP MED
JI J. Clin. Sleep Med.
PY 2018
VL 14
IS 9
BP 1463
EP 1470
DI 10.5664/jcsm.7314
PG 8
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology
GA HP1GP
UT WOS:000461414400003
PM 30176967
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Pinto, TS
   Feltran, GD
   Fernandes, CJD
   Andrade, AFD
   Coque, AD
   Silva, SL
   Abuderman, AA
   Zambuzzi, WF
   da Silva, RAF
AF Pinto, Thais Silva
   Feltran, Georgia da Silva.
   Fernandes, Celio Junior da C.
   Andrade, Amanda Fantini de Camargo
   Coque, Alex de Camargo
   Silva, Simone L.
   Abuderman, Abdulwahab A.
   Zambuzzi, Willian F.
   da Silva, Rodrigo A. Foganholi
TI Epigenetic changes in shear-stressed endothelial cells
SO CELL BIOLOGY INTERNATIONAL
LA English
DT Article
DE endothelial cell; epigenetics; HOTTIP; HOXA13; hypertension; shear
   stress
ID METABOLIC SYNDROME; HISTONE H3; UP-REGULATION; EXPRESSION; METHYLATION;
   FLOW; CHROMATIN; METHYLTRANSFERASE; DEACETYLASES; CHOLESTEROL
AB Epigenetic changes, particularly histone compaction modifications, have emerged as critical regulators in the epigenetic pathway driving endothelial cell phenotype under constant exposure to laminar forces induced by blood flow. However, the underlying epigenetic mechanisms governing endothelial cell behavior in this context remain poorly understood. To address this knowledge gap, we conducted in vitro experiments using human umbilical vein endothelial cells subjected to various tensional forces simulating pathophysiological blood flow shear stress conditions, ranging from normotensive to hypertensive forces. Our study uncovers a noteworthy observation wherein endothelial cells exposed to high shear stress demonstrate a decrease in the epigenetic marks H3K4ac and H3K27ac, accompanied by significant alterations in the levels of HDAC (histone deacetylase) proteins. Moreover, we demonstrate a negative regulatory effect of increased shear stress on HOXA13 gene expression and a concomitant increase in the expression of the long noncoding RNA, HOTTIP, suggesting a direct association with the suppression of HOXA13. Collectively, these findings represent the first evidence of the role of histone-related epigenetic modifications in modulating chromatin compaction during mechanosignaling of endothelial cells in response to elevated shear stress forces. Additionally, our results highlight the importance of understanding the physiological role of HOXA13 in vascular biology and hypertensive patients, emphasizing the potential for developing small molecules to modulate its activity. These findings warrant further preclinical investigations and open new avenues for therapeutic interventions targeting epigenetic mechanisms in hypertensive conditions.
   In vitro methodologies are employed as an initial approach to identify biomarkers associated with elevated shear stress in hypertension Mechanosignaling mediated by oscillatory shear stress necessitates the involvement of epigenetic modifications, particularly histone-mediated chromatin compression Enhanced shear stress levels lead to a reduction in the overall abundance of acetylation marks, specifically H3K4 and H3K27, in endothelial cells HOXA13 does not play a crucial role in the development of mechanosignaling induced by high shear stress The data demonstrates a positive Pearson correlation between the long noncoding RNA HOTTIP and HOXA13
C1 [Pinto, Thais Silva; Feltran, Georgia da Silva.; Fernandes, Celio Junior da C.; Andrade, Amanda Fantini de Camargo; Zambuzzi, Willian F.] Paulista State Univ UNESP, Inst Biosci, Dept Chem & Biol Sci, Lab Bioassays & Cellular Dynam, Botucatu, SP, Brazil.
   [Coque, Alex de Camargo; da Silva, Rodrigo A. Foganholi] Univ Paulista, Epigenet Study Ctr & Gene Regulat CEEpiRG, Program Environm & Expt Pathol, Sao Paulo, SP, Brazil.
   [Silva, Simone L.; da Silva, Rodrigo A. Foganholi] Univ Taubate, Sch Dent, Taubate, SP, Brazil.
   [Abuderman, Abdulwahab A.] Prince Sattam bin Abdulaziz Univ, Coll Med, Dept Basic Med Sci, Riyadh, Saudi Arabia.
   [da Silva, Rodrigo A. Foganholi] Paulista Univ UNIP, Program Environm & Expt Pathol, Sao Paulo, Brazil.
   [Zambuzzi, Willian F.] Univ Estadual Paulista, Inst Biociencias IBB, Lab Bioensaios & Dinam Celular, Dept Quim & Bioquim, Sao Paulo, Brazil.
C3 Universidade Estadual Paulista; Universidade Paulista; Universidade de
   Taubate; Prince Sattam Bin Abdulaziz University; Universidade Paulista;
   Universidade Estadual Paulista
RP da Silva, RAF (corresponding author), Paulista Univ UNIP, Program Environm & Expt Pathol, Sao Paulo, Brazil.; Zambuzzi, WF (corresponding author), Univ Estadual Paulista, Inst Biociencias IBB, Lab Bioensaios & Dinam Celular, Dept Quim & Bioquim, Sao Paulo, Brazil.
EM w.zambuzzi@unesp.br; dasilasilva.rodrigo.a@gmail.com
RI Pinto, Thaís/P-2307-2019; Zambuzzi, Willian/F-9519-2012; da Silva,
   Rodrigo Augusto/G-1222-2012
OI Camargo Coque, Alex/0000-0001-6207-4687; Silva Pinto,
   Thais/0000-0002-6287-6249; Fantini de Camargo Andrade,
   Amanda/0000-0002-8051-5519; Zambuzzi, Willian/0000-0002-4149-5965; da
   Silva, Rodrigo Augusto/0000-0002-7754-1855
FU Fundacao de Amparo a Pesquisa do Estado de Sao Paulo [2014/22689-3,
   2016/01139-0, 2017/18349-0]; Conselho Nacional de Desenvolvimento
   Cientifico e Tecnologico [001, 301498/2022-9]; Coordenacao de
   Aperfeicoamento de Pessoal de Nivel Superior;  [314166/2021-1]
FX Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (2014/22689-3;
   2016/01139-0; 2017/18349-0), Conselho Nacional de Desenvolvimento
   Cientifico e Tecnologico Grant/Award Numbers: 314166/2021-1,
   301498/2022-9; Coordenacao de Aperfeicoamento de Pessoal de Nivel
   Superior, Grant/Award Number: Code 001
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NR 70
TC 3
Z9 3
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1065-6995
EI 1095-8355
J9 CELL BIOL INT
JI Cell Biol. Int.
PD MAY
PY 2024
VL 48
IS 5
BP 665
EP 681
DI 10.1002/cbin.12138
EA FEB 2024
PG 17
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA NQ8V1
UT WOS:001175307700001
PM 38420868
DA 2025-06-11
ER

PT J
AU Costabile, G
   Vitale, M
   Della Pepa, G
   Cipriano, P
   Vetrani, C
   Testa, R
   Mena, P
   Bresciani, L
   Tassotti, M
   Calani, L
   Del Rio, D
   Brighenti, F
   Napoli, R
   Rivellese, AA
   Riccardi, G
   Giacco, R
AF Costabile, Giuseppina
   Vitale, Marilena
   Della Pepa, Giuseppe
   Cipriano, Paola
   Vetrani, Claudia
   Testa, Roberta
   Mena, Pedro
   Bresciani, Letizia
   Tassotti, Michele
   Calani, Luca
   Del Rio, Daniele
   Brighenti, Furio
   Napoli, Raffaele
   Rivellese, Angela A.
   Riccardi, Gabriele
   Giacco, Rosalba
TI A wheat aleurone-rich diet improves oxidative stress but does not
   influence glucose metabolism in overweight/obese individuals: Results
   from a randomized controlled trial
SO NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
LA English
DT Article
DE Wheat-aleurone; Whole-grain cereals; Betaine; Oxidative stress;
   Inflammation; Glucose metabolism
ID WHOLE-GRAIN; LIPID-PEROXIDATION; ARABINOXYLAN FIBER; PHENOLIC-COMPOUNDS;
   FERULIC ACID; PLASMA; CONSUMPTION; INSULIN; MARKERS; PRODUCTS
AB Background and aims: Aleurone is the innermost layer of wheat bran, rich in fiber, minerals, vitamins, phenolic compounds, and betaine. The metabolic effects of aleurone rich foods are still unknown. Our aim was to investigate the effects of consuming a Wheat Aleurone rich diet vs. a Refined Wheat diet for 8 weeks on fasting and postprandial glycemic and lipid metabolism, inflammation, and oxidative stress in overweight/obese individuals. Methods and results: According to a randomized cross-over study design, 23 overweight/obese individuals, age 56 +/- 9 years (M +/- SD), were assigned to two isoenergetic diet - Wheat Aleurone and Refined Wheat diets - for 8 weeks. The diets were similar for macronutrient composition but different for the aleurone content (40-50 g/day in the Wheat Aleurone diet). After each diet, fasting and postprandial plasma metabolic profile, ferulic acid metabolites and 8-isoprostane concentrations in 24-h urine samples were evaluated. Compared with the Refined Wheat Diet, the Wheat Aleurone Diet increased fasting plasma concentrations of betaine by 15% (p = 0.042) and decreased the excretion of 8-isoprostane by 33% (p = 0.035). Conversely, it did not affect the fasting and postprandial glucose, insulin and triglyceride responses, homocysteine, and C-Reactive Protein concentrations, nor excretion of phenolic metabolites. Conclusion: An 8-week Wheat Aleurone Diet improves the oxidative stress and increases plasma betaine levels in overweight/obese individuals with an increased cardiometabolic risk. However, further studies with longer duration and larger sample size are needed to evaluate the benefits of aleurone-rich foods on glucose and lipid metabolism in individuals with more severe metabolic abnormalities. (c) 2021 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.
C1 [Costabile, Giuseppina; Vitale, Marilena; Della Pepa, Giuseppe; Cipriano, Paola; Vetrani, Claudia; Testa, Roberta; Rivellese, Angela A.; Riccardi, Gabriele] Univ Naples Federico II, Dept Clin Med & Surg, Via Sergio Pansini 5, I-80131 Naples, Italy.
   [Mena, Pedro; Bresciani, Letizia; Tassotti, Michele; Calani, Luca; Del Rio, Daniele; Brighenti, Furio] Univ Parma, Dept Food & Drug, Human Nutr Unit, Via Volturno 39, I-43125 Parma, Italy.
   [Napoli, Raffaele] Univ Naples Federico II, Dept Translat Med Sci, Via Sergio Pansini 5, I-80131 Naples, Italy.
   [Giacco, Rosalba] CNR, Inst Food Sci, Via Roma 64,8, Avellino, Italy.
C3 University of Naples Federico II; University of Parma; University of
   Naples Federico II; Consiglio Nazionale delle Ricerche (CNR); Istituto
   di Scienze dell' Alimentazione (ISA-CNR)
RP Costabile, G (corresponding author), Univ Naples Federico II, Dept Clin Med & Surg, Via Pansini 5, I-80131 Naples, Italy.
EM giuseppina.costabile@unina.it
RI Napoli, Raffaele/AFW-3703-2022; Claudia, Vetrani/D-3306-2018; Della
   Pepa, Giuseppe Maria/AAC-1697-2019; Ciampalini, Paolo/K-4366-2016;
   brighenti, furio/E-4174-2010; Costabile, Giuseppina/AAJ-8382-2020; Del
   Rio, Daniele/E-8696-2010; Mena, Pedro/P-6353-2019; Vitale,
   Marilena/J-1457-2014
OI Del Rio, Daniele/0000-0001-5394-1259; Costabile,
   Giuseppina/0000-0001-5761-8002; Mena, Pedro/0000-0003-2150-2977; Vitale,
   Marilena/0000-0001-9951-4674; NAPOLI, Raffaele/0000-0002-3366-2321
FU Barilla G&R F.lli. SpA, Parma, Italy; European Commission, Project
   DiGuMet JPI-HDHL INTIMIC
FX This study was supported by the Barilla G&R F.lli. SpA, Parma, Italy and
   by the European Commission, Project DiGuMet JPI-HDHL INTIMIC.
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NR 48
TC 11
Z9 11
U1 3
U2 18
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 0939-4753
EI 1590-3729
J9 NUTR METAB CARDIOVAS
JI Nutr. Metab. Carbiovasc. Dis.
PD MAR
PY 2022
VL 32
IS 3
BP 715
EP 726
DI 10.1016/j.numecd.2021.12.016
EA FEB 2022
PG 12
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism; Nutrition
   & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism;
   Nutrition & Dietetics
GA ZE7LD
UT WOS:000759058700022
PM 35123855
DA 2025-06-11
ER

PT J
AU Varga, ZV
   Kupai, K
   Szucs, G
   Gáspár, R
   Pálóczi, J
   Faragó, N
   Zvara, A
   Puskás, LG
   Rázga, Z
   Tiszlavicz, L
   Bencsik, P
   Görbe, A
   Csonka, C
   Ferdinandy, P
   Csont, T
AF Varga, Zoltan V.
   Kupai, Krisztina
   Szucs, Gergo
   Gaspar, Renata
   Paloczi, Janos
   Farago, Nora
   Zvara, Agnes
   Puskas, Laszlo G.
   Razga, Zsolt
   Tiszlavicz, Laszlo
   Bencsik, Peter
   Goerbe, Aniko
   Csonka, Csaba
   Ferdinandy, Peter
   Csont, Tamas
TI MicroRNA-25-dependent up-regulation of NADPH oxidase 4 (NOX4) mediates
   hypercholesterolemia-induced oxidative/nitrative stress and subsequent
   dysfunction in the heart
SO JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
LA English
DT Article
DE Hyperlipidemia; Peroxynitrite; Superoxide; Metabolic syndrome;
   Cholesterol; Nitrosative stress
ID OXIDATIVE STRESS; CARDIAC DYSFUNCTION; PROMOTES APOPTOSIS;
   HIGH-CHOLESTEROL; GENE-EXPRESSION; NITRIC-OXIDE; DIET LEADS;
   INVOLVEMENT; PROTECTION; MICRORNAS
AB Diet-induced hypercholesterolemia leads to oxidative/nitrative stress and subsequent myocardial dysfunction. However, the regulatory role of microRNAs in this phenomenon is unknown. We aimed to investigate, whether hypercholesterolemia-induced myocardial microRNA alterations play a role in the development of oxidative/nitrative stress and in subsequent cardiac dysfunction. Male Wistar rats were fed with 2% cholesterol/0.25% cholate-enriched or standard diet for 12 weeks. Serum and tissue cholesterol levels were significantly elevated by cholesterol-enriched diet. Left ventricular end-diastolic pressure was significantly increased in cholesterol-fed rats both in vivo and in isolated perfused hearts, indicating diastolic dysfunction. Myocardial expression of microRNAs was affected by cholesterol-enriched diet as assessed by microarray analysis. MicroRNA-25 showed a significant down-regulation as detected by microarray analysis and QRT-PCR. In silico target prediction revealed NADPH oxidase 4 (NOX4) as a putative target of microRNA-25. NOX4 protein showed significant up-regulation in the hearts of cholesterol-fed rats, while NOX1 and NOX2 remained unaffected. Cholesterol-feeding significantly increased myocardial oxidative/nitrative stress as assessed by dihydroethidium staining, protein oxidation assay, and nitro-tyrosine ELISA, respectively. Direct binding of microRNA-25 mimic to the 3' UTR region of NOX4 was demonstrated using a luciferase reporter assay. Transfection of a microRNA-25 mimic into primary cardiomyocytes decreased superoxide production, while a microRNA-25 inhibitor resulted in an up-regulation of NOX4 protein and an increase in oxidative stress that was attenuated by the NADPH oxidase inhibitor diphenyleneiodonium. Here we demonstrated for the first time that hypercholesterolemia affects myocardial microRNA expression, and by down-regulating microRNA-25 increases NOX4 expression and consequently oxidative/nitrative stress in the heart. We conclude that hypercholesterolemia-induced microRNA alterations play an important role in the regulation of oxidative/nitrative stress and in consequent myocardial dysfunction. (C) 2013 Elsevier Ltd. All rights reserved.
C1 [Varga, Zoltan V.; Kupai, Krisztina; Szucs, Gergo; Gaspar, Renata; Paloczi, Janos; Bencsik, Peter; Goerbe, Aniko; Csonka, Csaba; Ferdinandy, Peter; Csont, Tamas] Univ Szeged, Cardiovasc Res Grp, Dept Biochem, H-6720 Szeged, Hungary.
   [Varga, Zoltan V.; Ferdinandy, Peter] Semmelweis Univ, Dept Pharmacol & Pharmacotherapy, H-1085 Budapest, Hungary.
   [Farago, Nora; Zvara, Agnes; Puskas, Laszlo G.] Hungarian Acad Sci, Biol Res Ctr, Inst Genet, H-6701 Szeged, Hungary.
   [Razga, Zsolt; Tiszlavicz, Laszlo] Univ Szeged, Dept Pathol, H-6720 Szeged, Hungary.
   [Bencsik, Peter; Goerbe, Aniko; Csonka, Csaba; Ferdinandy, Peter; Csont, Tamas] Pharmahungary Grp, Szeged, Hungary.
C3 Szeged University; Semmelweis University; HUN-REN; HUN-REN Biological
   Research Center; Institute of Genetics - HAS; Hungarian Academy of
   Sciences; Szeged University; Pharmahungary Group
RP Csont, T (corresponding author), Univ Szeged, Cardiovasc Res Grp, Dept Biochem, Dom Ter 9, H-6720 Szeged, Hungary.
EM csont.tamas@med.u-szeged.hu
RI Ferdinandy, Péter/H-9181-2019; Rázga, Zsolt/ABC-4837-2021; Bencsik,
   Peter/AFR-1290-2022; Szűcs, Gergő/O-8732-2019; Varga, Zoltan/J-9264-2017
OI Bencsik, Peter/0000-0003-1936-6232; Varga, Zoltan/0000-0002-2758-0784;
   Gaspar, Renata/0000-0001-9673-4532; Kupai,
   Krisztina/0000-0002-0644-1718; Paloczi, Janos/0000-0002-7691-4138;
   Csonka, Csaba/0000-0003-2532-6261; Razga, Zsolt/0000-0003-4717-8482;
   Szucs, Gergo/0000-0003-1874-2718
FU National Development Agency [BAROSS-DA07-DA-TECH-07-2008-0041]; New
   Hungary Development Plan [TAMOP-4.2.2-08/1/2008-0013,
   TAMOP-4.2.1/B-09/1/KONV-2010-0005, TAMOP-4.2.2/B-10/1-2010-0012,
   TAMOP-4.2.2.A-11/1/KONV-2012-0035]; Hungarian Scientific Research Fund
   [OTKA K79167]; Hungary-Romania Cross-Border Co-operation Program
   [HU-RO-TRANS-MED HURO/0901/137/2.2.2]; Hungarian Academy of Sciences;
   National Program of Excellence [TAMOP 4.2.4.A/1-11-1-2012-0001]
FX This work was supported by the following grants: National Development
   Agency (BAROSS-DA07-DA-TECH-07-2008-0041; MED_FOOD), New Hungary
   Development Plan (TAMOP-4.2.2-08/1/2008-0013,
   TAMOP-4.2.1/B-09/1/KONV-2010-0005, TAMOP-4.2.2/B-10/1-2010-0012,
   TAMOP-4.2.2.A-11/1/KONV-2012-0035), Hungarian Scientific Research Fund
   (OTKA K79167), and Hungary-Romania Cross-Border Co-operation Program
   2007-2013 (HU-RO-TRANS-MED HURO/0901/137/2.2.2). T.C., A.G. and A.Z.
   hold a "Janos Bolyai Fellowship" from the Hungarian Academy of Sciences.
   Z.V.V. was supported by the National Program of Excellence (TAMOP
   4.2.4.A/1-11-1-2012-0001).
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NR 58
TC 146
Z9 159
U1 2
U2 37
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0022-2828
EI 1095-8584
J9 J MOL CELL CARDIOL
JI J. Mol. Cell. Cardiol.
PD SEP
PY 2013
VL 62
BP 111
EP 121
DI 10.1016/j.yjmcc.2013.05.009
PG 11
WC Cardiac & Cardiovascular Systems; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Cell Biology
GA 198RV
UT WOS:000322940900015
PM 23722270
DA 2025-06-11
ER

PT J
AU Weigensberg, MJ
   Lane, CJ
   Avila, Q
   Konersman, K
   Ventura, E
   Adam, T
   Shoar, Z
   Goran, MI
   Spruijt-Metz, D
AF Weigensberg, Marc J.
   Lane, Christianne J.
   Avila, Quintilia
   Konersman, Kati
   Ventura, Emily
   Adam, Tanja
   Shoar, Zohreh
   Goran, Michael I.
   Spruijt-Metz, Donna
TI Imagine HEALTH: results from a randomized pilot lifestyle intervention
   for obese Latino adolescents using Interactive Guided
   Imagery<SUP>SM</SUP>
SO BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Article
DE Guided imagery; Obesity; Childhood; Latino; Adolescents; Lifestyle;
   Diabetes
ID BETA-CELL FUNCTION; STRESS-INDUCED CORTISOL; PITUITARY-ADRENAL AXIS;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; GLUCOSE-TOLERANCE;
   DIABETES-MELLITUS; CONTROLLED-TRIAL; DIETARY-INTAKE; OVERWEIGHT
AB Background: There is an urgent need for innovative and developmentally appropriate lifestyle interventions to promote healthy lifestyle behaviors and to prevent the early onset of type 2 diabetes and cardiovascular disease risk in obese Latino adolescents. Guided imagery offers promise to reduce stress and promote lifestyle behavior change to reduce disease risk in obese adolescents. Our objectives were: 1) To pilot test a new 12-wk lifestyle intervention using a randomized trial design in obese Latino adolescents, in order to determine the effects of the mind-body modality of Interactive Guided Imagery(SM) (IGI), over and above those of a didactic lifestyle education, on insulin resistance, eating and physical activity behaviors, stress and stress biomarkers; and 2) To explore the role of intervention-related changes in stress and stress biomarkers on changes in metabolic outcomes, particularly insulin resistance.
   Methods: Obese (BMI > 95th percentile), Latino adolescents (n = 35, age 14-17) were randomized to receive either 12 weekly sessions of a lifestyle education plus guided imagery program (GI), or lifestyle education plus a digital storytelling computer program (DS). Between-group differences in behavioral, biological, and psychological outcomes were assessed using unpaired T-tests and ANCOVA in the 29 subjects who completed the intervention.
   Results: The GI group demonstrated significant reductions in leisure sedentary behavior (p < .05) and increases in moderate physical activity (p < .05) compared to DS group, and a trend toward reduced caloric intake in GI vs DS (p = .09). Salivary cortisol was acutely reduced by stress-reduction guided imagery (p < .01). There were no group differences in adiposity, insulin resistance, perceived stress, or stress biomarkers across the 12-week intervention, though decrease in serum cortisol over the course of the intervention was associated with improved insulin sensitivity (p = .03) independent of intervention group and other relevant co-variates.
   Conclusions: The improvements in physical activity and stress biomarkers following this pilot intervention support the role of guided imagery in promoting healthy lifestyle behavior change and reducing metabolic disease risk in obese Latino adolescent populations. Future investigations will be needed to determine the full effects of the Imagine HEALTH intervention on insulin resistance, stress, and stress biomarkers.
C1 [Weigensberg, Marc J.; Avila, Quintilia; Konersman, Kati; Shoar, Zohreh] Univ So Calif, Keck Sch Med, Dept Pediat, Los Angeles, CA 90089 USA.
   [Lane, Christianne J.; Ventura, Emily; Adam, Tanja; Goran, Michael I.; Spruijt-Metz, Donna] Univ So Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90089 USA.
C3 University of Southern California; University of Southern California
RP Weigensberg, MJ (corresponding author), Univ So Calif, Keck Sch Med, Dept Pediat, 2250 Alcazar St,Ste 211, Los Angeles, CA 90089 USA.
EM weigensb@usc.edu
FU National Center for Complementary and Alternative Medicine [5 R21
   AT002556-02]; General Clinical Research Center NCRR/NIH Grant [M01RR
   00043]
FX This study was supported by National Center for Complementary and
   Alternative Medicine Grant 5 R21 AT002556-02 and by General Clinical
   Research Center NCRR/NIH Grant M01RR 00043.
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NR 73
TC 30
Z9 39
U1 0
U2 29
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1472-6882
J9 BMC COMPLEM ALTERN M
JI BMC Complement. Altern. Med.
PD JAN 17
PY 2014
VL 14
AR 28
DI 10.1186/1472-6882-14-28
PG 13
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Integrative & Complementary Medicine
GA AC5AV
UT WOS:000332533900001
PM 24433565
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Nichols, GA
   Brown, JB
AF Nichols, GA
   Brown, JB
TI Functional status before and after diagnosis of Type 2 diabetes
SO DIABETIC MEDICINE
LA English
DT Article
DE diabetes mellitus; diagnosis; functional status
ID MEDICAL-CARE COSTS; LIFE-STYLE; MELLITUS; DEPRESSION; ADULTS;
   HYPERTENSION; PREVALENCE; OUTCOMES; IMPACT
AB Aims We examined functional health status prior to the diagnosis of Type 2 diabetes, and measured the effect on functional health status of receiving the diagnosis.
   Methods After the ADA reduced its fasting plasma glucose level for diagnosing diabetes from > 7.8 to > 7.0 mmol/l, we identified 1014 members of a large HMO who met the new criteria, and an age- and gender-matched comparison group who did not. We mailed questionnaires to these subjects in 1998, and again in 1999 to 623 who met the new criteria, after some had been notified of their diabetes, while others had not. We used the SF-12(R) Health Survey to measure physical and mental subjective health status.
   Results Mean age of respondents meeting new diagnostic criteria (n = 498) was 67.3 + 10.4 years, 43.6% were women. Comparison group respondents (n = 589) were 66.7 + 10.6 years, 45.2% women. The groups were not statistically different on either characteristic. Prior to the diagnosis of Type 2 diabetes, physical functioning was already lower in subjects who met the new criteria than in the comparison group (39.5 vs. 42.1, P < 0.001), mental functioning was similar (51.4 vs. 51.9, P = 0.406). Among those who newly met diagnostic criteria for diabetes, there was no difference in the change in health status (mental or physical) in those who reported receiving a diagnosis (n = 105) compared with those who did not (n = 168).
   Conclusions Physical health status is already reduced prior to diabetes diagnosis, perhaps because of obesity or other aspects of the insulin resistance syndrome. Receiving a diabetes diagnosis after adjusting the diagnostic criteria does not adversely affect either mental or physical health status.
C1 Kaiser Permanente Ctr Hlth Res, Portland, OR 97227 USA.
C3 Kaiser Permanente
RP Nichols, GA (corresponding author), Kaiser Permanente Ctr Hlth Res, 3800 N Interstate Ave, Portland, OR 97227 USA.
EM greg.nichols@kpchr.org
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NR 19
TC 12
Z9 12
U1 1
U2 2
PU BLACKWELL PUBLISHING LTD
PI OXFORD
PA 9600 GARSINGTON RD, OXFORD OX4 2DG, OXON, ENGLAND
SN 0742-3071
J9 DIABETIC MED
JI Diabetic Med.
PD JUL
PY 2004
VL 21
IS 7
BP 793
EP 797
DI 10.1111/j.1464-5491.2004.01191.x
PG 5
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 831OZ
UT WOS:000222205400024
PM 15209777
DA 2025-06-11
ER

PT J
AU Blumberg, JB
   Basu, A
   Krueger, CG
   Lila, MA
   Neto, CC
   Novotny, JA
   Reed, JD
   Rodriguez-Mateos, A
   Toner, CD
AF Blumberg, Jeffrey B.
   Basu, Arpita
   Krueger, Christian G.
   Lila, Mary Ann
   Neto, Catherine C.
   Novotny, Janet A.
   Reed, Jess D.
   Rodriguez-Mateos, Ana
   Toner, Cheryl D.
TI Impact of Cranberries on Gut Microbiota and Cardiometabolic Health:
   Proceedings of the Cranberry Health Research Conference 2015
SO ADVANCES IN NUTRITION
LA English
DT Article; Proceedings Paper
CT Cranberry Health Research Conference
CY OCT 12, 2015
CL Madison, WI
SP Cranberry Inst, US Cranberry Mkt Comm, Amer Cranberry Growers Assoc
DE cranberry; proanthocyanidins; microbiome; cardiometabolic; antimicrobial
ID PATHOGENIC ESCHERICHIA-COLI; PLASMA ANTIOXIDANT CAPACITY; DIET-INDUCED
   OBESITY; C-REACTIVE PROTEIN; HIGH-FAT DIET; JUICE CONSUMPTION;
   MASS-SPECTROMETRY; OXIDATIVE STRESS; PROANTHOCYANIDINS IMPROVE;
   METABOLIC ENDOTOXEMIA
AB Recent advances in cranberry research have expanded the evidence for the role of this Vaccinium berry fruit in modulating gut microbiota function and cardiometabolic risk factors. The A-type structure of cranberry proanthocyanidins seems to be responsible for much of this fruit's efficacy as a natural antimicrobial. Cranberry proanthocyanidins interfere with colonization of the gut by extraintestinal pathogenic Escherichia coli in vitro and attenuate gut barrier dysfunction caused by dietary insults in vivo. Furthermore, new studies indicate synergy between these proanthocyanidins, other cranberry components such as isoprenoids and xyloglucans, and gut microbiota. Together, cranberry constituents and their bioactive catabolites have been found to contribute to mechanisms affecting bacterial adhesion, coaggregation, and biofilm formation that may underlie potential clinical benefits on gastrointestinal and urinary tract infections, as well as on systemic anti-inflammatory actions mediated via the gut microbiome. A limited but growing body of evidence from randomized clinical trials reveals favorable effects of cranberry consumption on measures of cardiometabolic health, including serum lipid profiles, blood pressure, endothelial function, glucoregulation, and a variety of biomarkers of inflammation and oxidative stress. These results warrant further research, particularly studies dedicated to the elucidation of dose-response relations, pharmacokinetic/metabolomics profiles, and relevant biomarkers of action with the use of fully characterized cranberry products. Freeze-dried whole cranberry powder and a matched placebo were recently made available to investigators to facilitate such work, including interlaboratory comparability.
C1 [Blumberg, Jeffrey B.] Tufts Univ, Jean Mayer USDA Human Nutr Res Ctr Aging, Boston, MA 02111 USA.
   [Basu, Arpita] Oklahoma State Univ, Stillwater, OK 74078 USA.
   [Krueger, Christian G.; Reed, Jess D.] Complete Phytochem Solut LLC, Cambridge, WI USA.
   [Krueger, Christian G.; Reed, Jess D.] Univ Wisconsin, Madison, WI USA.
   [Lila, Mary Ann] North Carolina State Univ, Kannapolis, NC USA.
   [Neto, Catherine C.] Univ Massachusetts Dartmouth, Dartmouth, MA USA.
   [Novotny, Janet A.] USDA, Beltsville Human Nutr Res Ctr, Beltsville, MD 20705 USA.
   [Rodriguez-Mateos, Ana] Univ Dusseldorf, Dusseldorf, Germany.
   [Toner, Cheryl D.] Cranberry Inst, Carver, MA USA.
   [Toner, Cheryl D.] CDT Consulting LLC, Herndon, VA USA.
C3 United States Department of Agriculture (USDA); Tufts University;
   Oklahoma State University System; Oklahoma State University -
   Stillwater; University of Wisconsin System; University of Wisconsin
   Madison; North Carolina State University; University of Massachusetts
   System; University Massachusetts Dartmouth; United States Department of
   Agriculture (USDA); Heinrich Heine University Dusseldorf
RP Blumberg, JB (corresponding author), Tufts Univ, Jean Mayer USDA Human Nutr Res Ctr Aging, Boston, MA 02111 USA.
EM jeffrey.blumberg@tufts.edu
RI Rodriguez-Mateos, Ana/ABE-1560-2020; Blumberg, Jeffrey/ABH-7888-2020
OI Lila, Mary Ann/0000-0002-4928-3836; Rodriguez-Mateos,
   Ana/0000-0003-3242-402X
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NR 115
TC 56
Z9 61
U1 3
U2 75
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 2161-8313
EI 2156-5376
J9 ADV NUTR
JI Adv. Nutr.
PD JUL
PY 2016
VL 7
IS 4
BP 759S
EP 770S
DI 10.3945/an.116.012583
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Nutrition & Dietetics
GA DS1FU
UT WOS:000380342000013
PM 27422512
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Wang, X
   Chen, LL
   Zhang, Q
AF Wang, Xia
   Chen, Lei-Lei
   Zhang, Qing
TI Increased Serum Level of Growth Differentiation Factor 15 (GDF-15) is
   Associated with Coronary Artery Disease
SO CARDIOVASCULAR THERAPEUTICS
LA English
DT Article
DE Coronary artery disease; Growth differentiation factor 15; ROC curve;
   Serum
ID INHIBITORY CYTOKINE-1 MIC-1/GDF15; BETA SUPERFAMILY MEMBER; CHRONIC
   HEART-FAILURE; C-REACTIVE PROTEIN; RISK STRATIFICATION;
   MYOCARDIAL-INFARCTION; ELDERLY INDIVIDUALS; PROGNOSTIC UTILITY; PREDICTS
   MORTALITY; OXIDATIVE STRESS
AB Aim: There is evidence suggesting that inflammatory responses play a critical role in the development of coronary artery disease (CAD). Growth differentiation factor 15 (GDF-15) is a stress-responsive cytokine. It increases during inflammatory processes and is associated with cardiometabolic risk. However, the relation between GDF-15 and CAD remains largely unknown. Herein, we aimed to evaluate serum GDF-15 levels and predictive values in patients with CAD. Methods: Serum levels of GDF-15 in 105 patients with CAD and 96 healthy controls were measured by the enzyme-linked immunosorbent assay. Gensini scores were used to assess severity of CAD. The correlations between the serum GDF-15 levels and Gensini scores were examined using Spearman's correlation. Receivers operating characteristic (ROC) curve analysis was performed to determine the predictive values of GDF-15 levels. Results: We found that serum GDF-15 levels were significantly increased in CAD group compared with healthy controls group (P < 0.001). Additionally, a positive correlation was observed between GDF-15 and the Gensini score (r = 0.85, P < 0.001). Moreover, the area under the ROC curve assay yielded a satisfactory result of 0.96 (95% confidence interval 0.94-0.98; P < 0.001), and the serum GDF-15 level had a 80.0% sensitivity and 91.7% specificity for predicting CAD. Conclusions: These data suggested that increased GDF-15 levels were positively associated with CAD, and GDF-15 might be a useful adjunct in discriminating CAD.
C1 [Wang, Xia] Nanjing Med Univ, Huaian Peoples Hosp 1, Dept Clin Lab, Huaian, Peoples R China.
   [Chen, Lei-Lei] Nanjing Med Univ, Affiliated Hosp 1, Dept Cardiol, Nanjing, Jiangsu, Peoples R China.
   [Zhang, Qing] Nanjing Med Univ, Huaian Peoples Hosp 1, Dept Cardiol, 6 Beijing West Rd, Huaian 223300, Jiangsu, Peoples R China.
C3 Nanjing Medical University; Nanjing Medical University; Nanjing Medical
   University
RP Zhang, Q (corresponding author), Nanjing Med Univ, Huaian Peoples Hosp 1, Dept Cardiol, 6 Beijing West Rd, Huaian 223300, Jiangsu, Peoples R China.
EM qinzhanga@126.com
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NR 48
TC 28
Z9 31
U1 0
U2 6
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1755-5914
EI 1755-5922
J9 CARDIOVASC THER
JI Cardiovasc. Ther.
PD JUN
PY 2016
VL 34
IS 3
BP 138
EP 143
DI 10.1111/1755-5922.12184
PG 6
WC Cardiac & Cardiovascular Systems; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Pharmacology & Pharmacy
GA DR5EG
UT WOS:000379925200002
PM 26996787
OA Bronze
DA 2025-06-11
ER

PT J
AU Gupta, S
   Totade, S
   Gupta, K
   Bamrah, P
   Gupta, S
   Gupta, S
AF Gupta, Swar
   Totade, Sangita
   Gupta, Kavita
   Bamrah, Parvinder
   Gupta, Shlok
   Gupta, Sunil
TI Management of Obese Type 1 Diabetes Mellitus (Double Diabetes) Through
   Telemedicine During COVID-19 Pandemic Lockdown: A Case Report
SO CUREUS JOURNAL OF MEDICAL SCIENCE
LA English
DT Article
DE weight loss and obesity; national lockdown; previous gestational
   diabetes mellitus; type 1 diabetes mellitus (t1d); covid-19
   telemedicine; medical nutrition therapy; double diabetes; covid-19 retro
ID INSULIN-RESISTANCE; PEDIATRIC-PATIENTS; METABOLIC SYNDROME; VALIDITY
AB Metabolic syndrome in Type 1 diabetes mellitus (T1DM) has been shown to be an independent risk factor for macro-vascular and micro-vascular complications. Obesity also affects many people with T1DM across their lifetime with an increasing prevalence in recent decades. Individuals with T1DM who are overweight, have a family history of type 2 diabetes, and/or have clinical features of insulin resistance, are known as "double diabetes". It is challenging for a person with double diabetes to achieve reasonable glycemic control, avoid insulin-related weight gain, and prevent hypoglycaemia. This was especially true during the coronavirus disease 2019 (COVID-19) pandemic lockdown. The aim of this report is to show that lifestyle modification through telemedicine can immensely help in managing uncontrolled T1DM with associated morbid obesity in lockdown situations, with the help of the diabetes educator. In this case, the complicated history of double diabetes was taken through telephonic and online consultations with the help of a nutritionist and diabetes educator, and the treating clinician supervised the insulin doses and frequency. Patient Health Questionnaire (PHQ)-9 questionnaire was used to assess depression. Medical nutrition therapy (MNT) was given through online consultations, where the patient was reoriented to carbohydrate counting, insulin dose adjustment, along with modifications in the diet. Regular exercise was advised along with frequent self-monitoring of blood glucose (SMBG). Moreover, the diet order was changed to eat protein and fibre first, followed by carbohydrates, later. The three-tier system of the medical expert, clinical dietitian, and diabetes educator was applied. The subject was trained for carbohydrate counting and insulin dose adjustment by teaching her about the insulin-to-carb ratio and insulin sensitivity factor (ISF). She was asked to examine her insulin injection sites by visual and palpatory methods for lipohypertrophy. Once a week, the diabetes educator and nutritionist did telephonic follow-up and counselling, while online consultation was done by the treating clinician once a month. As a result, her weight, BMI, and waist circumference were reduced drastically, and there was an improvement in haemoglobin A1C (HbA1C), lipid parameters, and blood pressure after the intervention. Thus, implementing diabetes education via telemedicine in circumstances such as the COVID-19 pandemic can help achieve the best possible compliance for strict diet adherence, regular exercise and monitoring, reducing obesity, glycosylated HbA1c, insulin doses, and risk of depression in a person with double diabetes.
C1 [Gupta, Swar; Totade, Sangita] Jawaharlal Nehru Med Coll, Pharmacol, Wardha, India.
   [Gupta, Kavita; Bamrah, Parvinder] Sunils Diabet Care N Res Ctr, Nutr, Nagpur, Maharashtra, India.
   [Gupta, Shlok] Sunils Diabet Care N Res Ctr, Internal Med, Nagpur, Maharashtra, India.
   [Gupta, Sunil] Sunils Diabet Care N Res Ctr, Endocrinol, Nagpur, Maharashtra, India.
C3 Datta Meghe Institute of Higher Education & Research (Deemed to be
   University); Jawaharlal Nehru Medical College Wardha
RP Gupta, S (corresponding author), Jawaharlal Nehru Med Coll, Pharmacol, Wardha, India.
EM swargupta17@gmail.com
RI Totade, sangita/ABB-6799-2020
OI Gupta, Swar Sunil/0009-0009-5342-3385
CR [Anonymous], 2020, MOD ORD 3 WEEK TOT L
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NR 16
TC 3
Z9 3
U1 0
U2 2
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
EI 2168-8184
J9 CUREUS J MED SCIENCE
JI Cureus J Med Sci
PD OCT 21
PY 2022
VL 14
IS 10
AR e30533
DI 10.7759/cureus.30533
PG 5
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA E9FY8
UT WOS:000978527200001
PM 36415365
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Niño, MD
   Hearne, BN
AF Nino, Michael D.
   Hearne, Brittany N.
TI Dimensions of acculturation and biological dysregulation among
   Latina/os: the role of ethnic background, gender, and immigrant
   generation
SO ETHNICITY & HEALTH
LA English
DT Article
DE Acculturation; allostatic load; Latina/os; Hispanic; immigrant
   generation; gender
ID ALLOSTATIC LOAD; SEGMENTED ASSIMILATION; SOCIOECONOMIC-STATUS; SKIN
   COLOR; HEALTH; STRESS; DISCRIMINATION; AGE; MACARTHUR; AMERICAN
AB Objective: Research examining how different dimensions of acculturative beliefs and behaviors influence the risk of biological dysregulation among Latina/os is limited. This study examined associations between three types of acculturation and allostatic load (i.e. a multisystem index of biological dysregulation) across gender and Latina/o ethnic groups. Multiplicative models were also included in order to determine whether immigrant generation moderates acculturation-allostatic load relationships.
   Design: Data were drawn from the Hispanic Community Health Study/ Study of Latina/os. The sample consisted of 11,841 Latina/os from five ethnic groups: Cuban, Puerto Rican, Dominican, Mexican, and South/Central American. The measure for allostatic load was derived from 15 biomarker and anthropometric measures that were designed to capture cardiometabolic risk, glucose metabolism, cardiopulmonary function, inflammation, and organ function. Acculturation measures, immigrant generation, gender, ethnic background, and other covariates were derived from self-reports. Survey corrected ordinary least squares regressions were used to assess relationships between different dimensions of acculturation and allostatic load.
   Results: Results demonstrate dimensions of acculturation play a significant role in the risk of biological dysregulation for Latina/os with divergent results across gender and ethnic background. Estimates from the multiplicative models show immigrant generation moderates acculturation-allostatic load relationships, and relationships are dependent on gender and ethnic background.
   Conclusion: The study contributes to the understanding of how different dimensions of acculturation, as well as other important structural determinants of health, influence the risk of biological dysregulation among Latina/os. Finding from this study can inform targeted strategies designed to reduce the physiological consequences of chronic stress among Latina/os.
C1 [Nino, Michael D.; Hearne, Brittany N.] Univ Arkansas, Dept Sociol & Criminol, Fayetteville, AR 72701 USA.
C3 University of Arkansas System; University of Arkansas Fayetteville
RP Niño, MD (corresponding author), Univ Arkansas, Dept Sociol & Criminol, Fayetteville, AR 72701 USA.
EM mdnino@uark.edu
FU National Heart, Lung, and Blood Institute (NHLBI) [N01-HC65233,
   N01-HC65234, N01-HC65235, N01-HC65236, N01-HC65237]; National Center of
   Minority Health and Health Disparities; National Institute of Deafness
   and Other Communications Disorders; National Institute of Dental
   Craniofacial Research; National Institute of Diabetes and Digestive
   Kidney Diseases; National Institute of Neurological Disorders and
   Stroke; Office of Dietary Supplements
FX This Hispanic Community Health Study/Study of Latinos was supported by
   contracts from the National Heart, Lung, and Blood Institute (NHLBI) to
   the University of North Carolina [grant number N01-HC65233], University
   of Miami [grant number N01-HC65234], Albert Einstein College of Medicine
   [grant N01-HC65235], Northwestern University [grant number N01-HC65236],
   and San Diego State University [grant number N01-HC65237]. The following
   Institutes/Centers/Offices contribute to the HCHS/SOL through a transfer
   of funds to the NHLBI: National Center of Minority Health and Health
   Disparities, the National Institute of Deafness and Other Communications
   Disorders, The National Institute of Dental Craniofacial Research, the
   National Institute of Diabetes and Digestive Kidney Diseases, The
   National Institute of Neurological Disorders and Stroke, and the Office
   of Dietary Supplements. Its contents are solely the responsibility of
   authors and do not represent the official views of the National
   Institutes of Health.
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NR 69
TC 12
Z9 15
U1 0
U2 6
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 1355-7858
EI 1465-3419
J9 ETHNIC HEALTH
JI Ethn. Health
PD MAY 19
PY 2022
VL 27
IS 4
BP 963
EP 979
DI 10.1080/13557858.2020.1821175
EA SEP 2020
PG 17
WC Ethnic Studies; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Ethnic Studies; Public, Environmental & Occupational Health
GA 1D1QN
UT WOS:000569433200001
PM 32931321
DA 2025-06-11
ER

PT J
AU Rodrigues, KD
   Klein, CP
   August, PM
   dos Santos, BG
   Hözer, RM
   Maurmann, RM
   Scortegagna, MC
   Hoppe, JB
   Matté, C
AF Rodrigues, Karoline dos Santos
   Klein, Caroline Peres
   August, Pauline Maciel
   dos Santos, Bernardo Gindri
   Hozer, Regis Mateus
   Maurmann, Rafael Moura
   Scortegagna, Mariana Crestani
   Hoppe, Juliana Bender
   Matte, Cristiane
TI Early weaning alters redox status in the hippocampus and hypothalamus of
   rat pups
SO INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
LA English
DT Article
DE DOHaD; early weaning; metabolic programming; redox status
ID VOLUNTARY RUNNING EXERCISE; OXIDATIVE STRESS; SOCIAL-ISOLATION;
   MATERNAL-DEPRIVATION; METABOLIC SYNDROME; PREFRONTAL CORTEX; EXPRESSION;
   BEHAVIOR; ANXIETY; PROGRAMS
AB Exposure to environmental factors can program the metabolism, conferring resistance or increasing the risk to chronic disease development in childhood and adulthood. In this sense, lactation is an important period in this window of development. Herein, we investigated the effect of early weaning on neurochemical and behavioral changes in offspring at weaning and adulthood. Female and male pups were divided into four groups: (1) Control weaning (weaning on the PND21, pups were kept with the biological mother); (2) Early Weaning Bromocriptine group (EWB) (pharmacological weaning on PND16); (3) Early Weaning Cross-Fostering group (EWCF) (pups housed with a foster mother on PND16 up to PND21); (4) Early Weaning Without Care group (EWWC) (weaning on PND16, maternal separation). Weight control of pups was recorded from postnatal Day 16 to 59. On the 21st day, part of the pups was euthanized and the hippocampus and hypothalamus were removed for biochemical evaluation. The remaining pups were submitted to behavioral tests on the 60th postnatal day. Early weaning reduced the pups' body weight, in a sex-dependent way. At 60 days of age, male pups of EWCF and EWWC groups have lower body weight compared to control male, and female body weight was lower than male pups. In relation to biochemical changes in the brain, weaning altered the levels of oxidants, increased the enzymatic activity of superoxide dismutase (SOD), and glutathione peroxidase (GPx), as well as induced lipid peroxidation. Weaning was also able to alter long-term memory and induce anxious behavior in pups. Our results demonstrate that the different types of early weaning changed the parameters of redox status in the hippocampus and hypothalamus of pups (21 days old), suggesting a prooxidative profile, in addition, to alter learning/memory and inducing an anxious behavior in male offspring (60 days old).
C1 [Rodrigues, Karoline dos Santos; August, Pauline Maciel; dos Santos, Bernardo Gindri; Hozer, Regis Mateus; Matte, Cristiane] Univ Fed Rio Grande do Sul, ICBS, Programa Posgrad Ciencias Biol Bioquim, Rua Ramiro Barcelos 2600, Porto Alegre, RS, Brazil.
   [Klein, Caroline Peres; Maurmann, Rafael Moura; Scortegagna, Mariana Crestani; Hoppe, Juliana Bender; Matte, Cristiane] Univ Fed Rio Grande do Sul, Inst Ciencias Basicas Saude, Dept Bioquim, Porto Alegre, RS, Brazil.
   [Matte, Cristiane] Univ Fed Rio Grande do Sul, ICBS, Programa Posgrad Ciencias Biol Fisiol, Porto Alegre, RS, Brazil.
C3 Universidade Federal do Rio Grande do Sul; Universidade Federal do Rio
   Grande do Sul; Universidade Federal do Rio Grande do Sul
RP Matté, C (corresponding author), Univ Fed Rio Grande do Sul, ICBS, Programa Posgrad Ciencias Biol Bioquim, Rua Ramiro Barcelos 2600, Porto Alegre, RS, Brazil.
EM matte@ufrgs.br
RI ; Klein, Caroline/V-4070-2018
OI dos Santos Rodrigues, Karoline/0000-0002-3230-9673; Gindri dos Santos,
   Bernardo/0000-0001-7641-9682; Klein, Caroline/0000-0002-0751-9441;
   Hozer, Regis/0000-0003-1129-9012; Matte, Cristiane/0000-0002-4720-6394;
   Maciel August, Pauline/0000-0003-0925-9986; Moura Maurmann,
   Rafael/0000-0003-1759-1778
FU ProReitoria de Pesquisa/Universidade Federal do Rio Grande do Sul
   (PROPESQ/UFRGS); Conselho Nacional de Desenvolvimento Cientifico e
   Tecnologico [CNPqUniversal 442406/2014-2]; INCT [465671/2014-4]
FX This study was supported by the ProReitoria de Pesquisa/Universidade
   Federal do Rio Grande do Sul (PROPESQ/UFRGS) and Conselho Nacional de
   Desenvolvimento Cientifico e Tecnologico (CNPqUniversal 442406/2014-2
   and INCT 465671/2014-4)
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NR 81
TC 2
Z9 2
U1 1
U2 9
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0736-5748
EI 1873-474X
J9 INT J DEV NEUROSCI
JI Int. J. Dev. Neurosci.
PD OCT
PY 2020
VL 80
IS 6
BP 512
EP 527
DI 10.1002/jdn.10047
EA JUL 2020
PG 16
WC Developmental Biology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Developmental Biology; Neurosciences & Neurology
GA OB5LM
UT WOS:000557570500001
PM 32619317
DA 2025-06-11
ER

PT J
AU You, MM
   Liu, YC
   Chen, YF
   Pan, YM
   Miao, ZN
   Shi, YZ
   Si, JJ
   Chen, ML
   Hu, FL
AF You, Meng-Meng
   Liu, Yi-Chen
   Chen, Yi-Fan
   Pan, Yong-Ming
   Miao, Zhuo-Ning
   Shi, Yi-Zhen
   Si, Juan-Juan
   Chen, Min-Li
   Hu, Fu-Liang
TI Royal jelly attenuates nonalcoholic fatty liver disease by inhibiting
   oxidative stress and regulating the expression of circadian genes in
   ovariectomized rats
SO JOURNAL OF FOOD BIOCHEMISTRY
LA English
DT Article
DE menopause; nonalcoholic fatty liver disease; ovariectomized rat; Royal
   jelly
ID METABOLIC SYNDROME; IN-VITRO; CARDIOVASCULAR-DISEASE; ACID; ESTROGEN;
   STEATOSIS; RECEPTORS; IMPROVES; ORIGIN; PHYTOL
AB Nonalcoholic fatty liver disease (NAFLD) has a high incidence in postmenopausal women and is accompanied by insulin resistance, obesity, and dyslipidemia. Royal jelly (RJ), a natural substance derived from hive, possesses numerous health-beneficial properties. Here, we evaluated the effects of RJ (150, 300, and 450 mg kg(-1) day(-1), 8 weeks) on NAFLD in ovariectomized (OVX) rats. Based on the results, RJ ameliorated the degree of anxiety, improved serum lipid profile, and attenuated the hepatic steatosis and liver injury in OVX rats. Furthermore, the protective effects of RJ could be attributed to its antioxidant properties, which enhance the levels of hepatic antioxidant enzymes. The qRT-PCR results also suggest that RJ improves the disturbances of circadian genes by downregulating their expression, including that of Per1 and Per 2, in the liver of OVX rats. Altogether, our findings suggest that RJ may be a promising agent for the treatment of NAFLD. Practical applications Postmenopausal women are at an increased risk of NAFLD. Currently, there are no licensed therapies for NAFLD. Although hormone replacement therapy (HRT) is reported to inhibit the development of NAFLD, it causes unexpected adverse effects. As HRT is controversial, the use of natural supplements to counteract the detrimental effects of menopause has recently attracted more attention. RJ is a natural product secreted from the hypopharyngeal and mandibular glands of worker bees. The present study illustrates the protective effect of the natural product, RJ, and its underlying mechanisms on NAFLD. This is the first study to assess the effect of RJ on NAFLD under estrogen deficiency. Such findings contribute to the further utilization of RJ, which might serve as a promising therapeutic option and natural food for the treatment of NAFLD.
C1 [You, Meng-Meng; Liu, Yi-Chen; Chen, Yi-Fan; Miao, Zhuo-Ning; Shi, Yi-Zhen; Si, Juan-Juan; Hu, Fu-Liang] Zhejiang Univ, Coll Anim Sci, Hangzhou 310058, Zhejiang, Peoples R China.
   [Pan, Yong-Ming; Chen, Min-Li] Zhejiang Chinese Med Univ, Expt Anim Res Ctr, Hangzhou, Zhejiang, Peoples R China.
C3 Zhejiang University; Zhejiang Chinese Medical University
RP Hu, FL (corresponding author), Zhejiang Univ, Coll Anim Sci, Hangzhou 310058, Zhejiang, Peoples R China.
EM flhu@zju.edu.cn
RI liu, yichen/GVT-6262-2022
OI Chen, Yifan/0000-0003-2628-5764
FU National Natural Science Foundation of China [31872431]; Modern
   Agroindustry Technology Research System from the Ministry of Agriculture
   of China [CARS-44]
FX National Natural Science Foundation of China, Grant/Award Number:
   31872431; Modern Agroindustry Technology Research System from the
   Ministry of Agriculture of China, Grant/Award Number: CARS-44
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NR 58
TC 20
Z9 20
U1 0
U2 25
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0145-8884
EI 1745-4514
J9 J FOOD BIOCHEM
JI J. Food Biochem.
PD MAR
PY 2020
VL 44
IS 3
AR e13138
DI 10.1111/jfbc.13138
EA JAN 2020
PG 12
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA KT6JX
UT WOS:000505044500001
PM 31894585
OA gold
DA 2025-06-11
ER

PT J
AU Chen, CY
   Asakawa, A
   Fujimiya, M
   Lee, SD
   Inui, A
AF Chen, Chih-Yen
   Asakawa, Akihiro
   Fujimiya, Mineko
   Lee, Shou-Dong
   Inui, Akio
TI Ghrelin Gene Products and the Regulation of Food Intake and Gut Motility
SO PHARMACOLOGICAL REVIEWS
LA English
DT Review
ID GROWTH-HORMONE SECRETAGOGUE; DES-ACYL GHRELIN; Y GASTRIC BYPASS;
   HYPOTHALAMIC ARCUATE NUCLEUS; POSTPRANDIAL PLASMA GHRELIN;
   PROTEIN-COUPLED RECEPTOR; MESSENGER-RNA EXPRESSION;
   CHRONIC-RENAL-FAILURE; FREE FATTY-ACIDS; BODY-MASS INDEX
AB A breakthrough using "reverse pharmacology" identified and characterized acyl ghrelin from the stomach as the endogenous cognate ligand for the growth hormone (GH) secretagogue receptor (GHS-R) 1a. The unique post-translational modification of O-n-octanoylation at serine 3 is the first in peptide discovery history and is essential for GH-releasing ability. Des-acyl ghrelin, lacking O-n-octanoylation at serine 3, is also produced in the stomach and remains the major molecular form secreted into the circulation. The third ghrelin gene product, obestatin, a novel 23-amino acid peptide identified from rat stomach, was found by comparative genomic analysis. Three ghrelin gene products actively participate in modulating appetite, adipogenesis, gut motility, glucose metabolism, cell proliferation, immune, sleep, memory, anxiety, cognition, and stress. Knockdown or knockout of acyl ghrelin and/or GHS-R1a, and overexpression of desacyl ghrelin show benefits in the therapy of obesity and metabolic syndrome. By contrast, agonism of acyl ghrelin and/or GHS-R1a could combat human anorexia-cachexia, including anorexia nervosa, chronic heart failure, chronic obstructive pulmonary disease, liver cirrhosis, chronic kidney disease, burn, and postsurgery recovery, as well as restore gut dysmotility, such as diabetic or neurogenic gastroparesis, and postoperative ileus. The ghrelin acyl-modifying enzyme, ghrelin O-Acyltransferase (GOAT), which attaches octanoate to serine-3 of ghrelin, has been identified and characterized also from the stomach. To date, ghrelin is the only protein to be octanylated, and inhibition of GOAT may have effects only on the stomach and is unlikely to affect the synthesis of other proteins. GOAT may provide a critical molecular target in developing novel therapeutics for obesity and type 2 diabetes.
C1 [Asakawa, Akihiro; Inui, Akio] Kagoshima Univ, Grad Sch Med & Dent Sci, Dept Psychosomat Internal Med, Kagoshima 8908520, Japan.
   [Chen, Chih-Yen; Lee, Shou-Dong] Natl Yang Ming Univ, Sch Med, Fac Med, Taipei 112, Taiwan.
   [Chen, Chih-Yen; Lee, Shou-Dong] Taipei Vet Gen Hosp, Dept Med, Div Gastroenterol, Taipei, Taiwan.
   [Fujimiya, Mineko] Sapporo Med Univ, Sch Med, Dept Anat, Sapporo, Hokkaido, Japan.
C3 Kagoshima University; National Yang Ming Chiao Tung University; Taipei
   Veterans General Hospital; Sapporo Medical University
RP Inui, A (corresponding author), Kagoshima Univ, Grad Sch Med & Dent Sci, Dept Psychosomat Internal Med, 8-35-1 Sakuragaoka, Kagoshima 8908520, Japan.
EM inui@m.kufm.kagoshima-u.ac.jp
FU Taipei Veterans General Hospital, Taiwan; Department of Health, Taiwan
FX C.-Y. C. received the Great Academic Achievement Award at the 50th
   Anniversary of Taipei Veterans General Hospital, Taiwan, and was awarded
   a Clinical Physician Research Scholarship from the Department of Health,
   Taiwan.
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NR 590
TC 194
Z9 207
U1 0
U2 31
PU AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3995 USA
SN 0031-6997
EI 1521-0081
J9 PHARMACOL REV
JI Pharmacol. Rev.
PD DEC
PY 2009
VL 61
IS 4
BP 430
EP 481
DI 10.1124/pr.109.001958
PG 52
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 536MT
UT WOS:000273049200003
PM 20038570
DA 2025-06-11
ER

PT J
AU Morse, ML
   Beem, LW
AF Morse, Melvin L.
   Beem, Lance W.
TI Benefits of Reiki Therapy for a Severely Neutropenic Patient with
   Associated Influences on a True Random Number Generator
SO JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE
LA English
DT Article
AB Background: Reiki therapy is documented for relief of pain and stress. Energetic healing has been documented to alter biologic markers of illness such as hematocrit. True random number generators are reported to be affected by energy healers and spiritually oriented conscious awareness.
   Methods: The patient was a then 54-year-old severely ill man who had hepatitis C types 1 and 2 and who did not improve with conventional therapy. He also suffered from obesity, the metabolic syndrome, asthma, and hypertension. He was treated with experimental high-dose interferon/riboviron therapy with resultant profound anemia and neutropenia. Energetic healing and Reiki therapy was administered initially to enhance the patient's sense of well-being and to relieve anxiety. Possible effects on the patient's absolute neutrophil count and hematocrit were incidentally noted. Reiki therapy was then initiated at times of profound neutropenia to assess its possible effect on the patient's absolute neutrophil count (ANC). Reiki and other energetic healing sessions were monitored with a true random number generator (RNG).
   Results: Statistically significant relationships were documented between Reiki therapy, a quieting of the electronically created white noise of the RNG during healing sessions, and improvement in the patient's ANC. The immediate clinical result was that the patient could tolerate the high-dose interferon regimen without missing doses because of absolute neutropenia. The patient was initially a late responder to interferon and had been given a 5% chance of clearing the virus. He remains clear of the virus 1 year after treatment.
   Conclusions: The association between changes in the RNG, Reiki therapy, and a patient's ANC is the first to the authors' knowledge in the medical literature. Future studies assessing the effects of energetic healing on specific biologic markers of disease are anticipated. Concurrent use of a true RNG may prove to correlate with the effectiveness of energetic therapy.
C1 [Morse, Melvin L.] Inst Sci Study Consciousness, Georgetown, DE 19947 USA.
   [Beem, Lance W.] Keri Beem Res Fdn, Sacramento, CA USA.
RP Morse, ML (corresponding author), Inst Sci Study Consciousness, 26282 Lewes Georgetown Highway, Georgetown, DE 19947 USA.
EM melvinmorse@hotmail.com
FU Kari Beem Research Foundation
FX This case report was supported by the Kari Beem Research Foundation.
   Thanks to Jane Sherman, RN, PhD for her helpful review and comments on
   the manuscript, and to Paul H, Smith, PhD, John Stahler of IRVA
   (International Remote Viewers Association), and Michael Morse (National
   Science Foundation) for help with understanding and conceptualizing the
   true random number generator. The research subject and participants in
   this study signed consent forms and were fully informed of their rights
   according to the standards of the National Institutes of Health Human
   Subjects Protocol for participation in research studies.
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NR 22
TC 4
Z9 7
U1 0
U2 12
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1075-5535
EI 1557-7708
J9 J ALTERN COMPLEM MED
JI J. Altern. Complement Med.
PD DEC
PY 2011
VL 17
IS 12
BP 1181
EP 1190
DI 10.1089/acm.2010.0238
PG 10
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA 863IO
UT WOS:000298156200016
PM 22132706
OA Green Published
DA 2025-06-11
ER

PT J
AU Murphy, MO
   Herald, JB
   Leachman, J
   Tezanos, AV
   Cohn, DM
   Loria, AS
AF Murphy, Margaret O.
   Herald, Joseph B.
   Leachman, Jacqueline
   Tezanos, Alejandro Villasante
   Cohn, Dianne M.
   Loria, Analia S.
TI A model of neglect during postnatal life heightens obesity-induced
   hypertension and is linked to a greater metabolic compromise in female
   mice
SO INTERNATIONAL JOURNAL OF OBESITY
LA English
DT Article
ID ADVERSE CHILDHOOD EXPERIENCES; STRESS HYPORESPONSIVE PERIOD; CATCH-UP
   GROWTH; 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1; MATERNAL
   SEPARATION; MINERALOCORTICOID RECEPTOR; GENE-EXPRESSION;
   GLUCOCORTICOID-RECEPTOR; CARDIOVASCULAR-DISEASE; RISK
AB Exposure to early life stress (ELS) is associated with behavioral-related alterations, increases in body mass index and higher systolic blood pressure in humans. Postnatal maternal separation and early weaning (MSEW) is a mouse model of neglect characterized by a long-term dysregulation of the neuroendocrine system.
   Objectives Given the contribution of adrenal-derived hormones to the development of obesity, we hypothesized that exposure to MSEW could contribute to the worsening of cardiometabolic function in response to chronic high-fat diet (HF) feeding by promoting adipose tissue expansion and insulin resistance.
   Subjects MSEW was performed in C57BL/6 mice from postnatal days 2-16 and weaned at postnatal day 17. Undisturbed litters weaned at postnatal day 21 served as the control (C) group. At the weaning day, mice were placed on a low-fat diet (LF) or HF for 16 weeks.
   Results When fed a LF, male and female mice exposed to MSEW display similar body weight but increased fat mass compared to controls. However, when fed a HF, only female MSEW mice display increased body weight, fat mass, and adipocyte hypertrophy compared with controls. Also, female MSEW mice display evidence of an early onset of cardiometabolic risk factors, including hyperinsulinemia, glucose intolerance, and hypercholesterolemia. Yet, both male and female MSEW mice fed a HF show increased blood pressure compared with controls.
   Conclusions This study shows that MSEW promotes a sex-specific dysregulation of the adipose tissue expansion and glucose homeostasis that precedes the development of obesity-induced hypertension.
C1 [Murphy, Margaret O.; Herald, Joseph B.; Leachman, Jacqueline; Cohn, Dianne M.; Loria, Analia S.] Univ Kentucky, Dept Pharmacol & Nutr Sci, Lexington, KY 40506 USA.
   [Tezanos, Alejandro Villasante] Univ Kentucky, Dept Stat, Lexington, KY USA.
C3 University of Kentucky; University of Kentucky
RP Loria, AS (corresponding author), Univ Kentucky, Dept Pharmacol & Nutr Sci, Lexington, KY 40506 USA.
EM analia.loria@uky.edu
OI Villasante Tezanos, Alejandro/0000-0001-5108-8637
FU NIH National Heart, Lung, and Blood Institute [R00 HL111354]; University
   of Kentucky; University of Kentucky Center of Research in Obesity and
   Cardiovascular Disease [COBRE P20 GM103527]
FX This study was supported by funds from the NIH National Heart, Lung, and
   Blood Institute R00 HL111354 to ASL, start-up funds from the University
   of Kentucky to ASL, and the pilot project from the University of
   Kentucky Center of Research in Obesity and Cardiovascular Disease COBRE
   P20 GM103527 to ASL.
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NR 77
TC 28
Z9 30
U1 0
U2 1
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0307-0565
EI 1476-5497
J9 INT J OBESITY
JI Int. J. Obes.
PD JUL
PY 2018
VL 42
IS 7
BP 1354
EP 1365
DI 10.1038/s41366-018-0035-z
PG 12
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA GN7SJ
UT WOS:000439346500011
PM 29535450
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Brancatisano, A
   Wahlroos, S
   Brancatisano, R
AF Brancatisano, Anthony
   Wahlroos, Sara
   Brancatisano, Roy
TI Improvement in comorbid illness after placement of the Swedish
   Adjustable Gastric Band
SO SURGERY FOR OBESITY AND RELATED DISEASES
LA English
DT Article; Proceedings Paper
CT Annual Meeting of the
   International-Federation-for-the-Surgery-of-Obesity-and-Metabolic-Disord
   ers
CY SEP 05, 2007
CL Porto, PORTUGAL
SP Int Federat Surg Obesity & Metabol Dis, Ethicon Endo-Surg Inc
DE Morbid obesity; Laparoscopic adjustable gastric banding; LAGB; Bariatric
   surgery; Comorbidity; Quality of life
ID QUALITY-OF-LIFE; TYPE-2 DIABETES-MELLITUS; BODY-MASS INDEX;
   MORBID-OBESITY; WEIGHT-LOSS; METABOLIC SYNDROME; BARIATRIC SURGERY;
   BYPASS-SURGERY; FOLLOW-UP; GASTROESOPHAGEAL-REFLUX
AB Background: Obesity and its related comorbid illnesses have become a national health priority. We report comorbidity and quality of life (QoL) data after weight loss with gastric banding using the Swedish Adjustable Gastric Band (SAGB).
   Methods: Data were collected prospectively for 838 Consecutive morbidly obese patients who Underwent laparoscopic adjustable gastric banding (LAGB) between January 2001 and July 2007. patients were followed-up by a Multidisciplinary team consisting of a Surgeon. Physician, dietician, and exercise consultant. all of whom were involved in the evaluation of clinical Outcomes. Continuous data were reported as mean +/- SD; categorical data were reported as number and percentage. Patients served as their own controls.
   Results: Respective preoperative mean age, weight, and body mass index (BMI) were 44 years (range 16-76). 1222 kg (range 86-240), and 44 kg/m(2) (range 35-86). respectively. SAGB implantation was accomplished by the pars flaccida technique with no conversion to an open procedure. Mature follow-up data were available for 35% of patients at 24 months and 21% at 36 months. In the total cohort of 838 patients. BMI (mean +/- SD) decreased to 32 5 kg/m(2) and 32 7 kg/m(2) at 24 months and 36 months, respectively. Percentage excess weight loss (%EWL) (mean +/- SD) was 32% +/- 14% (n = 506), 47%; +/- 15% (n = 461). 52% +/- 16% (n = 291). and 54% +/- 23% (n = 175) at 6, 12. 24, and 36 months, respectively (P <.001). There were 545 patients identified with comorbid illness at >6-month follow-up, After a median follow-up of 13 months (range 6-36 months), resolution and/or improvement of comorbidities was as follows; type 2 diabetes mellitus. 79%; metabolic syndrome, 79%; hypertension. 67%; dyslipidemia. 66%; gastroesophageal reflux. 66%; asthma, 57% arthritis/joint pain, 70% polycystic ovarian syndrome, 48%; and depression. 57%. There was a significant improvement in QoL (as measured by the Short Form-36 Health Survey [SF-36]). bringing patients' QoL to a level consistent with that of community norms in all 8 domain scores. Of 342 patients surveyed with the Beck Depression Inventory (BDI-II), a statistically significant improvement in depressive mood was also observed (P <.001).
   Conclusion: Weight loss achieved by use of the SAGB provides a dramatic reduction in many serious comorbid illnesses as well as improvement in the psychosocial wellbeing of morbidly obese patients. (Surg Obes Relat Dis 2008;4;S39-S46.) (C) 2008 American Society for Metabolic and Bariatric Surgery. All rights reserved.
C1 [Brancatisano, Anthony; Wahlroos, Sara; Brancatisano, Roy] Inst Weight Control, Sydney, NSW 2154, Australia.
C3 Circle of Care
RP Brancatisano, A (corresponding author), Inst Weight Control, 495 Windsor Rd, Sydney, NSW 2154, Australia.
EM tony.brancatisano@iwes.net.au
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NR 75
TC 56
Z9 61
U1 0
U2 3
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1550-7289
EI 1878-7533
J9 SURG OBES RELAT DIS
JI Surg. Obes. Relat. Dis.
PD MAY-JUN
PY 2008
VL 4
IS 3
SU S
BP S39
EP S46
DI 10.1016/j.soard.2008.04.006
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery
GA 378FD
UT WOS:000261305700006
PM 18501314
DA 2025-06-11
ER

PT J
AU Koufakis, T
   Karras, SN
   Antonopoulou, V
   Angeloudi, E
   Zebekakis, P
   Kotsa, K
AF Koufakis, Theocharis
   Karras, Spyridon N.
   Antonopoulou, Vasiliki
   Angeloudi, Eleni
   Zebekakis, Pantelis
   Kotsa, Kalliopi
TI Effects of Orthodox religious fasting on human health: a systematic
   review
SO EUROPEAN JOURNAL OF NUTRITION
LA English
DT Review
DE Religious fasting; Macronutrients; Vitamins; Cardiometabolic risk;
   Musculoskeletal health
ID BECK DEPRESSION INVENTORY; PERIODIC VEGETARIANISM; MEDITERRANEAN DIET;
   HDL-CHOLESTEROL; SERUM-LIPIDS; CHRISTIANS; NUTRIENT; BENEFITS; RAMADAN;
   CALCIUM
AB Purpose Different studies have pointed towards a positive effect of religious fasting on human health. Orthodox fasting (OF) regime could be characterized as a periodical vegetarian diet, demonstrating several common characteristics with the typical Mediterranean diet. The present systematic review aimed to synthesize available results regarding the potential impact of OF on human health.
   Methods Key biomedical databases were searched to identify studies examining the effects of OF on humans. Following implementation of specific criteria, ten studies were included in the analysis and their results were systematically reported and critically appraised in this review.
   Results According to the available limited results, OF periods are characterized by a restriction in total energy and fat intake, an increase in carbohydrate and fiber consumption, while in terms of protein intake, results are contradictive. The overall effect of OF on lipids profile seems to be optimal, with the reduction of total cholesterol and LDL-C levels, being a consistent finding across studies (up to 17.8 and 31.4%, respectively). However, the effect on HDL-C is still unclear. Conclusions regarding the impact on body weight and glucose homeostasis cannot be drawn, given that relevant data are limited with conflicting results. Any potential negative aspects of OF, mainly attributed to reduced dietary intake of vitamin D and B12 and minerals (mainly calcium), require further investigation.
   Conclusions Given the limitations of available evidence, more studies are required before reaching definite conclusions about the effects of OF on human health.
C1 [Koufakis, Theocharis; Karras, Spyridon N.; Antonopoulou, Vasiliki; Angeloudi, Eleni; Zebekakis, Pantelis; Kotsa, Kalliopi] Aristotle Univ Thessaloniki, Div Endocrinol, Med Sch, AHEPA Hosp, 1 St Kiriakidi St, Thessaloniki 54636, Greece.
   [Koufakis, Theocharis; Karras, Spyridon N.; Antonopoulou, Vasiliki; Angeloudi, Eleni; Zebekakis, Pantelis; Kotsa, Kalliopi] Aristotle Univ Thessaloniki, Metab Diabet Ctr, Med Sch, Dept Internal Med 1,AHEPA Hosp, 1 St Kiriakidi St, Thessaloniki 54636, Greece.
C3 Aristotle University of Thessaloniki; Ahepa University Hospital;
   Aristotle University of Thessaloniki; Ahepa University Hospital
RP Karras, SN (corresponding author), Aristotle Univ Thessaloniki, Div Endocrinol, Med Sch, AHEPA Hosp, 1 St Kiriakidi St, Thessaloniki 54636, Greece.; Karras, SN (corresponding author), Aristotle Univ Thessaloniki, Metab Diabet Ctr, Med Sch, Dept Internal Med 1,AHEPA Hosp, 1 St Kiriakidi St, Thessaloniki 54636, Greece.
EM karraspiros@yahoo.gr
RI KOUFAKIS, THEOCHARIS/ABH-8156-2020; Kotsa, Kalliopi/K-8638-2019
OI Karras, Spyridon/0000-0002-4225-2746; Koufakis,
   Theocharis/0000-0002-5853-1352; Angeloudi, Elena/0000-0003-3492-7915
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NR 37
TC 27
Z9 30
U1 0
U2 26
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1436-6207
EI 1436-6215
J9 EUR J NUTR
JI Eur. J. Nutr.
PD DEC
PY 2017
VL 56
IS 8
BP 2439
EP 2455
DI 10.1007/s00394-017-1534-8
PG 17
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA FM3YE
UT WOS:000414945800002
PM 28856433
DA 2025-06-11
ER

PT J
AU Liu, J
   Li, CM
   Yang, Y
   Li, JT
   Sun, XG
   Zhang, YQ
   Liu, RP
   Chen, FF
   Li, XJY
AF Liu, Jia
   Li, Changmeng
   Yang, Yun
   Li, Jingtao
   Sun, Xiaoguang
   Zhang, Yinqiang
   Liu, Runping
   Chen, Fafeng
   Li, Xiaojiaoyang
TI Special correlation between diet and MASLD: positive or negative?
SO CELL AND BIOSCIENCE
LA English
DT Review
DE MASLD; Dietary models; Pathological mechanism; Dietary therapy; Curative
   strategy; Hepato-intestinal axis
ID FATTY LIVER-DISEASE
AB Metabolic dysfunction-associated steatotic liver disease (MASLD) is a chronic and systemic metabolic liver disease characterized by the presence of hepatic steatosis and at least one cardiometabolic risk factor (CMRF). The pathogenesis of MASLD involves multiple mechanisms, including lipid metabolism disorders, insulin resistance, inflammatory responses, and the hepato-intestinal axis of metabolic dysfunction. Among these factors, diet serves as both an inducement and a potential remedy in the disease's development. Notably, a high-lipid diet exacerbates fat accumulation, oxidative stress, and inflammatory responses, thereby promoting the progression of MASLD. Consequently, dietary induction models have become vital tools for studying the pathological mechanisms of MASLD, providing a foundation for identifying potential therapeutic targets. Additionally, we summarize the therapeutic effects of dietary optimization on MASLD and elucidate the role of specific dietary components in regulating the hepato-intestinal axis, lipid metabolism, and inhibiting inflammatory responses. In conclusion, studies utilizing animal models of MASLD offer significant insights into dietary therapy, particularly concerning the regulation of lipid metabolism-related and hepatoenteric axis-related signaling pathways as well as the beneficial mechanism of probiotics in hepatoenteric regulation. By understanding the specific mechanisms by which different dietary patterns affect MASLD, we can assess the clinical applicability of current dietary strategies and provide new directions for research and treatment aimed at disease modification.Graphical Abstract The double-edged sword role of dietary intake in the development of MASLD. An unhealthy diet leads to hepatic steatosis, fat accumulation, oxidative stress, and inflammation. In contrast, a balanced diet can prevent or alleviate MASLD progression.
C1 [Liu, Jia; Yang, Yun; Li, Xiaojiaoyang] Beijing Univ Chinese Med, Sch Life Sci, Beijing 100029, Peoples R China.
   [Li, Changmeng; Liu, Runping] Beijing Univ Chinese Med, Sch Chinese Mat Med, Beijing 100029, Peoples R China.
   [Li, Jingtao] Shaanxi Univ Chinese Med, Affiliated Hosp, Dept Infect Dis, Xianyang 712000, Peoples R China.
   [Sun, Xiaoguang; Chen, Fafeng] Beijing Univ Chinese Med, Sch Tradit Chinese Med, Beijing 100029, Peoples R China.
   [Zhang, Yinqiang] China Acad Chinese Med Sci, Xiyuan Hosp, Beijing, Peoples R China.
C3 Beijing University of Chinese Medicine; Beijing University of Chinese
   Medicine; Shaanxi University of Chinese Medicine; Beijing University of
   Chinese Medicine; China Academy of Chinese Medical Sciences; Xiyuan
   Hospital, CACMS
RP Li, XJY (corresponding author), Beijing Univ Chinese Med, Sch Life Sci, Beijing 100029, Peoples R China.
EM xiaojiaoyang.li@bucm.edu.cn
RI Li, Xiaojiaoyang/CAG-6603-2022; liu, runping/V-2733-2018
OI Li, Xiaojiaoyang/0000-0003-0291-5856
FU National Key Research and Development Program on Modernization of
   Traditional Chinese Medicine [2022YFC3502100]; National Natural Science
   Foundation of China [82274201, 82322075]; National High-Level Talents
   Special Support Program; China Academy of Chinese Medical Sciences
   [CI2021A00805]; National Administration of Traditional Chinese
   Medicine-Beijing University of Chinese Medicine, Chinese Medicine
   Epidemic Disease [zyyzdxk-2023264]
FX This work was supported by grants from National Key Research and
   Development Program on Modernization of Traditional Chinese Medicine
   (NO. 2022YFC3502100 to XL and RL); National Natural Science Foundation
   of China (Grant NO. 82274201 and 82322075 to RL); the National
   High-Level Talents Special Support Program to XL; Scientific and
   technological innovation project of China Academy of Chinese Medical
   Sciences (Grant NO. CI2021A00805 to YZ); High-level traditional Chinese
   medicine key subjects construction project of National Administration of
   Traditional Chinese Medicine-Beijing University of Chinese Medicine,
   Chinese Medicine Epidemic Disease (Grant NO. zyyzdxk-2023264 to XL).
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NR 105
TC 0
Z9 0
U1 5
U2 5
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 2045-3701
J9 CELL BIOSCI
JI Cell Biosci.
PD APR 12
PY 2025
VL 15
IS 1
AR 44
DI 10.1186/s13578-025-01382-1
PG 28
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 1HT6T
UT WOS:001465328300001
PM 40221799
DA 2025-06-11
ER

PT J
AU Cansby, E
   Magnusson, E
   Nuñez-Durán, E
   Amrutkar, M
   Pedrelli, M
   Parini, P
   Hoffmann, J
   Ståhlman, M
   Howell, BW
   Marschall, HU
   Borén, J
   Mahlapuu, M
AF Cansby, Emmelie
   Magnusson, Elin
   Nunez-Duran, Esther
   Amrutkar, Manoj
   Pedrelli, Matteo
   Parini, Paolo
   Hoffmann, Jenny
   Stahlman, Marcus
   Howell, Brian W.
   Marschall, Hanns-Ulrich
   Boren, Jan
   Mahlapuu, Margit
TI STK25 Regulates Cardiovascular Disease Progression in a Mouse Model of
   Hypercholesterolemia
SO ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
LA English
DT Article
DE atherosclerosis; cholesterol; fibrosis; inflammation; liver
ID FATTY LIVER-DISEASE; PROTEIN-KINASE STK25; VASCULAR OXIDATIVE STRESS;
   INSULIN-RESISTANCE; NITRIC-OXIDE; MONOCYTE HETEROGENEITY; HEPATIC
   STEATOSIS; MICE; ATHEROSCLEROSIS; EXPRESSION
AB Objective Recent cohort studies have shown that nonalcoholic fatty liver disease (NAFLD), and especially nonalcoholic steatohepatitis (NASH), associate with atherosclerosis and cardiovascular disease, independently of conventional cardiometabolic risk factors. However, the mechanisms underlying the pathophysiological link between NAFLD/NASH and cardiovascular disease still remain unclear. Our previous studies have identified STK25 (serine/threonine protein kinase 25) as a critical determinant in ectopic lipid storage, meta-inflammation, and progression of NAFLD/NASH. The aim of this study was to assess whether STK25 is also one of the mediators in the complex molecular network controlling the cardiovascular disease risk.
   Approach and Results Atherosclerosis was induced in Stk25 knockout and transgenic mice, and their wild-type littermates, by gene transfer of gain-of-function mutant of PCSK9 (proprotein convertase subtilisin/kexin type 9), which induces the downregulation of hepatic LDLR (low-density lipoprotein receptor), combined with an atherogenic western-type diet. We found that Stk25(-/-) mice displayed reduced atherosclerosis lesion area as well as decreased lipid accumulation, macrophage infiltration, collagen formation, and oxidative stress in aortic lesions compared with wild-type littermates, independently from alterations in dyslipidemia. Reciprocally, Stk25 transgenic mice presented aggravated plaque formation and maturation compared with wild-type littermates despite similar levels of fasting plasma cholesterol. We also found that STK25 protein was expressed in all layers of the aorta, suggesting a possible direct role in cardiovascular disease.
   Conclusions This study provides the first evidence that STK25 plays a critical role in regulation of cardiovascular disease risk and suggests that pharmacological inhibition of STK25 function may provide new possibilities for prevention/treatment of atherosclerosis.
C1 [Cansby, Emmelie; Magnusson, Elin; Nunez-Duran, Esther; Hoffmann, Jenny; Mahlapuu, Margit] Univ Gothenburg, Inst Med, Dept Mol & Clin Med, Lundberg Lab Diabet Res, Gothenburg, Sweden.
   [Stahlman, Marcus; Marschall, Hanns-Ulrich; Boren, Jan] Univ Gothenburg, Inst Med, Dept Mol & Clin Med, Wallenberg Lab, Gothenburg, Sweden.
   [Amrutkar, Manoj] Sahlgrens Univ Hosp, Gothenburg, Sweden.
   [Amrutkar, Manoj] Univ Oslo, Inst Clin Med, Dept Hepatopancreatobiliary Surg, Oslo, Norway.
   [Pedrelli, Matteo; Parini, Paolo] Karolinska Inst, Dept Lab Med, Stockholm, Sweden.
   [Parini, Paolo] Karolinska Inst, Metab Unit, Dept Med, Stockholm, Sweden.
   [Howell, Brian W.] SUNY Upstate Med Univ, Dept Neurosci & Physiol, Syracuse, NY 13210 USA.
C3 University of Gothenburg; University of Gothenburg; Sahlgrenska
   University Hospital; University of Oslo; Karolinska Institutet;
   Karolinska Institutet; State University of New York (SUNY) System; State
   University of New York (SUNY) Upstate Medical Center
RP Mahlapuu, M (corresponding author), Univ Gothenburg, Sahlgrenska Acad, Dept Mol & Clin Med, Lundberg Lab Diabet Res, Bla Straket 5, SE-41345 Gothenburg, Sweden.
EM margit.mahlapuu@gu.se
RI Marschall, Hanns-Ulrich/K-8842-2017; Amrutkar, Manoj/J-2848-2019;
   Mahlapuu, Margit/MVU-2841-2025; StÃ¥hlman, Marcus/M-4597-2019
OI Marschall, Hanns-Ulrich/0000-0001-7347-3085; Pedrelli,
   Matteo/0000-0003-0771-0569; Parini, Paolo/0000-0002-6541-8542; Howell,
   Brian/0000-0002-0204-0773; Mahlapuu, Margit/0000-0001-8740-8874
FU Swedish Research Council; European Foundation for the Study of
   Diabetes/Lilly European Diabetes Research Programme; West Sweden Medical
   Training and Research Agreement (Avtal om Lakarutbildning och Forskning;
   ALF) Program; Novo Nordisk Foundation; Swedish Heart and Lung
   Foundation; Torsten Soderbergs Foundation; Diabetes Wellness Network
   Sweden; Swedish Diabetes Foundation; Royal Society of Arts and Sciences
   in Gothenburg; Wiberg Foundation; Langmanska Kulturfonden; Adlerbert
   Research Foundation; I. Hultman Foundation; S. and E. Goljes Foundation;
   F. Neubergh Foundation; I.-B. and A. Lundbergs Research Foundation; L.
   and J. Gronberg Foundation Stiftelsen Prof N. Svartz Fond
FX This work was supported by grants from the Swedish Research Council, the
   European Foundation for the Study of Diabetes/Lilly European Diabetes
   Research Programme, the West Sweden Medical Training and Research
   Agreement (Avtal om Lakarutbildning och Forskning; ALF) Program, the
   Novo Nordisk Foundation, the Swedish Heart and Lung Foundation, the
   Torsten Soderbergs Foundation, the Diabetes Wellness Network Sweden, the
   Swedish Diabetes Foundation, the Royal Society of Arts and Sciences in
   Gothenburg, the Wiberg Foundation, Langmanska Kulturfonden, the
   Adlerbert Research Foundation, the I. Hultman Foundation, the S. and E.
   Goljes Foundation, the F. Neubergh Foundation, the I.-B. and A.
   Lundbergs Research Foundation, and the L. and J. Gronberg Foundation
   Stiftelsen Prof N. Svartz Fond.
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NR 55
TC 12
Z9 14
U1 1
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1079-5642
EI 1524-4636
J9 ARTERIOSCL THROM VAS
JI Arterioscler. Thromb. Vasc. Biol.
PD AUG
PY 2018
VL 38
IS 8
BP 1723
EP 1737
DI 10.1161/ATVBAHA.118.311241
PG 15
WC Hematology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Hematology; Cardiovascular System & Cardiology
GA GO4AL
UT WOS:000439942200010
PM 29930001
DA 2025-06-11
ER

PT J
AU Beckman, JA
   Wood, BR
   Ard, KL
   Price, CN
   Solomon, DA
   Zuflacht, JP
   Milian, J
   Prenner, JC
   Sax, PE
AF Beckman, Joshua A.
   Wood, Brian R.
   Ard, Kevin L.
   Price, Christin N.
   Solomon, Daniel A.
   Zuflacht, Jonah P.
   Milian, Jessica
   Prenner, Joshua C.
   Sax, Paul E.
TI Conflicting effects of atazanavir therapy on atherosclerotic risk
   factors in stable HIV patients: A randomized trial of regimen switch to
   atazanavir
SO PLOS ONE
LA English
DT Article
ID VON-WILLEBRAND-FACTOR; INTIMA-MEDIA THICKNESS; THROMBOTIC
   THROMBOCYTOPENIC PURPURA; ENDOTHELIAL FUNCTION; ANTIRETROVIRAL THERAPY;
   GILBERT-SYNDROME; DIABETES-MELLITUS; INFECTED PERSONS; OXIDATIVE STRESS;
   BRACHIAL-ARTERY
AB Bilirubin acts as a potent endogenous antioxidant, with higher concentrations associated with lower rates of CVD; the antiretroviral drug atazanavir (ATV) increases bilirubin levels but may also increase von Willebrand factor levels. We tested the hypothesis that increasing endogenous bilirubin using ATV would improve cardiometabolic risk factors and vascular function in older patients with HIV. Ninety participants were enrolled in two study protocols. In protocol 1, we evaluated markers of inflammation, thrombosis, and conduit artery endothelial function in subjects on non-ATV containing regimens. Participants were randomly assigned to continue baseline treatment or switch to an ATV-based regimen. Measurements were made at baseline and 28 days. In the protocol 2, we enrolled 30 subjects who received atazanavir for more than one year and were compared to the aim 1 protocol subjects at baseline. 60 subjects were enrolled in the first protocol (mean age 53, +/- 6 years), with 31 randomized to ATV and 29 continuing baseline treatment. Atazanavir significantly increased serum total bilirubin levels (p < 0.001) and acutely but not chronically plasma total antioxidant capacity (p < 0.001). An increase in von Willebrand Factor (p < 0.001) and reduction in hs-CRP (p = 0.034) were noted. No changes were seen in either flow-mediated endo-thelium-dependent or vasodilation. In cross-sectional analysis (second protocol), similar findings were seen in the baseline attributes of non-atazanavir-based and long-term atazanavir users. Increasing serum bilirubin levels with atazanavir in subjects with HIV reduces hs-CRP, temporarily reduces oxidative stress, but increases von Willebrand Factor. Atazanavir does not improve endothelial function of conduit arteries.
C1 [Beckman, Joshua A.] Vanderbilt Univ, Med Ctr, Cardiovasc Div, Nashville, TN 37235 USA.
   [Wood, Brian R.; Ard, Kevin L.; Price, Christin N.; Solomon, Daniel A.; Sax, Paul E.] Brigham & Womens Hosp, Div Infect Dis, 75 Francis St, Boston, MA 02115 USA.
   [Zuflacht, Jonah P.; Milian, Jessica; Prenner, Joshua C.] Brigham & Womens Hosp, Div Cardiovasc, 75 Francis St, Boston, MA 02115 USA.
C3 Vanderbilt University; Harvard University; Harvard University Medical
   Affiliates; Brigham & Women's Hospital; Harvard University; Harvard
   University Medical Affiliates; Brigham & Women's Hospital
RP Beckman, JA (corresponding author), Vanderbilt Univ, Med Ctr, Cardiovasc Div, Nashville, TN 37235 USA.
EM Joshua.a.beckman@vanderbilt.edu
RI ; Beckman, Joshua/A-7537-2016
OI Prenner, Joshua/0009-0001-5147-4869; Beckman,
   Joshua/0000-0001-8332-8439; Keilson, Jessica/0000-0002-8695-431X
FU Bristol Myers Squibb [2011A051378]
FX Funding provided by Bristol Myers Squibb grant 2011A051378,
   https;//www.brns.com/researchers-and-partners/independent-research.html.
   The funders had no role in study design, data collection and analysis,
   decision to publish, or preparation of the manuscript.
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NR 58
TC 8
Z9 8
U1 0
U2 0
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD OCT 12
PY 2017
VL 12
IS 10
AR e0181993
DI 10.1371/journal.pone.0181993
PG 14
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA FJ6DU
UT WOS:000412845100002
PM 29023508
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Heidari, M
   Chaboksafar, M
   Alizadeh, M
   Sohrabi, B
   Kheirouri, S
AF Heidari, Marzieh
   Chaboksafar, Maryam
   Alizadeh, Mohammad
   Sohrabi, Bahram
   Kheirouri, Sorayya
TI Effects of Astaxanthin supplementation on selected metabolic parameters,
   anthropometric indices, Sirtuin1 and TNF-α levels in patients with
   coronary artery disease: A randomized, double-blind, placebo-controlled
   clinical trial
SO FRONTIERS IN NUTRITION
LA English
DT Article
DE coronary artery disease; astaxanthin; lipid profile; glycemic indices;
   inflammation
ID OXIDATIVE STRESS; RISK-FACTORS; SIRT1; INFLAMMATION; ATHEROSCLEROSIS;
   INHIBITION; OVERWEIGHT; EXTRACT
AB Background: Atherosclerosis can develop as a result of an increase in oxidative stress and concurrently rising levels of inflammation. Astaxanthin (AX), a red fat-soluble pigment classified as a xanthophyll, may be able to prevent the vascular damage induced by free radicals and the activation of inflammatory signaling pathways. The objective of the current study is to assess the effects of AX supplementation on cardiometabolic risk factors in individuals with coronary artery disease (CAD).
   Methods: This randomized double-blind placebo-controlled clinical trial was conducted among 50 CAD patients. Participants were randomly allocated into two groups to intake either AX supplements (12 mg/day) or placebo for 8 weeks. Lipid profile, glycemic parameters, anthropometric indices, body composition, Siruin1 and TNF-alpha levels were measured at baseline and after 8 weeks. Results: Body composition, glycemic indices, serum levels of TNF-alpha, Sirtuin1 did not differ substantially between the AX and placebo groups (p > 0.05). The data of AX group showed significant reduction in total cholesterol (-14.95 +/- 33.57 mg/dl, p < 0.05) and LDL-C (-14.64 +/- 28.27 mg/dl, p < 0.05). However, TG and HDL-C levels could not be affected through AX supplementation
   .Conclusion: Our results suggest that AX supplementation play a beneficial role in reducing some components of lipid profile levels. However, further clinical investigations in CAD patients are required to obtain more conclusive findings.
C1 [Heidari, Marzieh; Chaboksafar, Maryam; Alizadeh, Mohammad] Tabriz Univ Med Sci, Fac Nutr & Food Sci, Dept Clin Nutr, Tabriz, Iran.
   [Sohrabi, Bahram] Tabriz Univ Med Sci, Cardiovasc Res Ctr, Tabriz, Iran.
   [Kheirouri, Sorayya] Tabriz Univ Med Sci, Fac Nutr, Dept Nutr, Tabriz, Iran.
C3 Tabriz University of Medical Science; Tabriz University of Medical
   Science; Tabriz University of Medical Science
RP Alizadeh, M (corresponding author), Tabriz Univ Med Sci, Fac Nutr & Food Sci, Dept Clin Nutr, Tabriz, Iran.
EM mdalizadeh@tbzmed.ac.ir
RI Alizadeh, Mohammad/M-4703-2017; sohrabi, bahram/M-5636-2017
FU Tabriz University of Medical Sciences [65868]
FX Funding Tabriz University of Medical Sciences supported this study
   (grant number 65868).
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NR 46
TC 6
Z9 6
U1 0
U2 2
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD MAR 27
PY 2023
VL 10
AR 1104169
DI 10.3389/fnut.2023.1104169
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA D1OU4
UT WOS:000966492100001
PM 37051124
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Wang, B
   Liu, W
   Yu, LL
   Ye, Z
   Cheng, M
   Qiu, WH
   Zhou, M
   Ma, JX
   Wang, X
   Yang, M
   Song, JH
   Chen, WH
AF Wang, Bin
   Liu, Wei
   Yu, Linling
   Ye, Zi
   Cheng, Man
   Qiu, Weihong
   Zhou, Min
   Ma, Jixuan
   Wang, Xing
   Yang, Meng
   Song, Jiahao
   Chen, Weihong
TI Acrolein Exposure Impaired Glucose Homeostasis and Increased Risk of
   Type 2 Diabetes: An Urban Adult Population-Based Cohort Study with
   Repeated Measures
SO ENVIRONMENTAL SCIENCE & TECHNOLOGY
LA English
DT Article
DE acrolein; environmental health; glucose homeostasis; type 2 diabetes;
   mediating mechanism; oxidative stress
ID VOLATILE ORGANIC-COMPOUNDS; EXHALED CARBON-MONOXIDE; OXIDATIVE
   DNA-DAMAGE; PROTEIN CARBONYLATION; STRESS; METABOLITES; ASSOCIATIONS;
   BIOMARKERS
AB Acrolein is an identified high-priority hazardous air pollutant ubiquitous in daily life and associated with cardiometabolic risk that attracts worldwide attention. However, the etiology role of acrolein exposure in glucose dyshomeostasis and type 2 diabetes (T2D) is unclear. This repeated-measurement prospective cohort study included 3522 urban adults. Urine/blood samples were repeatedly collected for determinations of acrolein metabolites (N-acetyl-S-(3-hydroxypropyl)-L-cysteine, N-acetyl-S-(2-carboxyethyl)-L-cysteine; acrolein exposure biomarkers), glucose homeostasis, and T2D at baseline and a three-year follow-up. We found that each 3-fold increment in acrolein metabolites was cross-sectionally associated with 5.91-6.52% decrement in homeostasis model assessment-insulin sensitivity (HOMA-IS) and 0.07-0.14 mmol/L, 4.02-4.57, 5.91- 6.52, 19-20, 18-19, and 23-31% increments in fasting glucose (FPG), fasting insulin (FPI), HOMA-insulin resistance (HOMA-IR), risks of prevalent IR, impaired fasting glucose (IFG), and T2D, respectively; longitudinally, participants with sustained-high acrolein metabolite levels had increased risks of incident IR, IFG, and T2D by 63-80, 87-99, and 120-154%, respectively (P < 0.05). In addition, biomarkers of heme oxygenase-1 activity (exhaled carbon monoxide), lipid peroxidation (8-iso-prostaglandin-F2 alpha), protein carbonylation (protein carbonyls), and oxidative DNA damage (8-hydroxy-deoxyguanosine) mediated 5.00-38.96% of these associations. Our study revealed that acrolein exposure may impair glucose homeostasis and increase T2D risk via mediating mechanisms of heme oxygenase-1 activation, lipid peroxidation, protein carbonylation, and oxidative DNA damage.
C1 [Wang, Bin; Liu, Wei; Yu, Linling; Ye, Zi; Cheng, Man; Qiu, Weihong; Zhou, Min; Ma, Jixuan; Wang, Xing; Song, Jiahao; Chen, Weihong] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Dept Occupat & Environm Hlth, Wuhan 430030, Hubei, Peoples R China.
   [Wang, Bin; Liu, Wei; Yu, Linling; Ye, Zi; Zhou, Min; Ma, Jixuan; Wang, Xing; Song, Jiahao; Chen, Weihong] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Key Lab Environm & Hlth,Minist Educ, Wuhan 430030, Hubei, Peoples R China.
   [Wang, Bin; Liu, Wei; Yu, Linling; Ye, Zi; Zhou, Min; Ma, Jixuan; Wang, Xing; Song, Jiahao; Chen, Weihong] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Minist Environm Protect, Wuhan 430030, Hubei, Peoples R China.
   [Wang, Bin; Liu, Wei; Yu, Linling; Ye, Zi; Zhou, Min; Ma, Jixuan; Wang, Xing; Song, Jiahao; Chen, Weihong] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, State Key Lab Environm Hlth Incubating, Wuhan 430030, Hubei, Peoples R China.
   [Cheng, Man] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Wuhan 430030, Hubei, Peoples R China.
   [Qiu, Weihong] Fujian Med Univ, Sch Publ Hlth, Dept Epidemiol & Hlth Stat, Fuzhou 350122, Peoples R China.
   [Yang, Meng] Huazhong Univ Sci & Technol, Wuhan Childrens Hosp, Wuhan Maternal & Child Hlth Care Hosp, Tongji Med Coll, Wuhan 430019, Hubei, Peoples R China.
C3 Huazhong University of Science & Technology; Huazhong University of
   Science & Technology; Ministry of Education - China; Huazhong University
   of Science & Technology; Huazhong University of Science & Technology;
   Huazhong University of Science & Technology; Fujian Medical University;
   Huazhong University of Science & Technology
RP Chen, WH (corresponding author), Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Dept Occupat & Environm Hlth, Wuhan 430030, Hubei, Peoples R China.; Chen, WH (corresponding author), Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Key Lab Environm & Hlth,Minist Educ, Wuhan 430030, Hubei, Peoples R China.; Chen, WH (corresponding author), Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Minist Environm Protect, Wuhan 430030, Hubei, Peoples R China.
EM wchen@mails.tjmu.edu.cn
RI Chen, Weihong/D-2177-2011; Li, Li/AEM-3636-2022; song,
   jiahao/GQP-4395-2022; ye, zi/JXM-9859-2024; Wei, Hongye/LDG-0955-2024;
   li, weihao/GWZ-3120-2022
OI Qiu, Weihong/0000-0002-8812-0976; Wei, Liu/0000-0001-5163-9742
FU Major Research Program of the National Natural Science Foundation of
   China [91843302]; National Natural Science Foundation of China
   [82203996]; China Postdoctoral Science Foundation [2021M691131,
   2022T150230]
FX Funding This study was supported by the Major Research Program of the
   National Natural Science Foundation of China (grant number 91843302) ,
   the National Natural Science Foundation of China (grant number 82203996)
   , and the China Postdoctoral Science Foundation (grant number
   2021M691131 and 2022T150230) .
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NR 55
TC 32
Z9 32
U1 8
U2 55
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0013-936X
EI 1520-5851
J9 ENVIRON SCI TECHNOL
JI Environ. Sci. Technol.
PD MAY 9
PY 2023
VL 57
IS 18
BP 7162
EP 7173
DI 10.1021/acs.est.2c09299
EA APR 2023
PG 12
WC Engineering, Environmental; Environmental Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering; Environmental Sciences & Ecology
GA F7QS5
UT WOS:000979800700001
PM 37098180
DA 2025-06-11
ER

PT J
AU van de Bool, C
   Steiner, MC
   Schols, AMWJ
AF van de Bool, Coby
   Steiner, Michael C.
   Schols, Annemie M. W. J.
TI Nutritional targets to enhance exercise performance in chronic
   obstructive pulmonary disease
SO CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE
LA English
DT Review
DE chronic obstructive pulmonary disease; exercise; nutrition; pulmonary
   rehabilitation; skeletal muscle
ID RANDOMIZED CONTROLLED-TRIAL; VASTUS LATERALIS MUSCLE;
   AMINO-ACID-METABOLISM; SKELETAL-MUSCLE; VITAMIN-D; OXIDATIVE STRESS;
   CREATINE SUPPLEMENTATION; MECHANICAL EFFICIENCY; GLUTAMATE METABOLISM;
   ENERGY-EXPENDITURE
AB Purpose of review
   This review presents current knowledge regarding the rationale and efficacy of nutrition as an ergogenic aid to enhance the effects of exercise and training in chronic obstructive pulmonary disease (COPD).
   Recent findings
   Altered body composition and skeletal muscle dysfunction in COPD suggest that exercise capacity can be targeted via several metabolic routes. Muscle metabolic alterations in COPD include a reduced oxidative metabolism and enhanced susceptibility for oxidative stress. Muscle wasting may be associated with deficiencies of vitamin D and low branched-chain amino acid levels. Exercise training is of established benefit in COPD but clear-cut clinical trial evidence to support the performance enhancing effect of nutritional intervention is lacking. One randomized controlled trial suggested that augmentation of training with polyunsaturated fatty acids may improve exercise capacity. Conflicting results are reported on dietary creatine supplementation in patients with COPD receiving pulmonary rehabilitation and results from acute intervention studies do not directly imply long-term effects of glutamate or glutamine supplementation as an ergogenic aid in COPD. Recent data indicate that not only muscle but also visceral fat may be an important additional target for combined nutrition and exercise intervention in COPD to improve physical performance and decrease cardiometabolic risk.
   Summary
   There is a clear need for adequately powered and controlled intervention and maintenance trials to establish the role of nutritional supplementation in the enhancement of exercise performance and training and the wider management of the systemic features of the disease.
C1 [van de Bool, Coby; Schols, Annemie M. W. J.] Maastricht Univ, Med Ctr, NUTRIM Sch Nutr Toxicol & Metab, Dept Resp Med, NL-6202 AZ Maastricht, Netherlands.
   [Steiner, Michael C.] Univ Hosp Leicester NHS Trust, Dept Resp Med, Inst Lung Hlth, Leicester, Leics, England.
C3 Maastricht University; Maastricht University Medical Centre (MUMC);
   University of Leicester; University Hospitals of Leicester NHS Trust
RP Schols, AMWJ (corresponding author), Maastricht Univ, Med Ctr, NUTRIM Sch Nutr Toxicol & Metab, Dept Resp Med, POB 5800, NL-6202 AZ Maastricht, Netherlands.
EM a.schols@maastrichtuniversity.nl
OI Steiner, Michael/0000-0002-0127-0614
FU MRC [G0501985] Funding Source: UKRI; Medical Research Council [G0501985]
   Funding Source: Medline
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NR 66
TC 17
Z9 18
U1 0
U2 36
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1363-1950
EI 1473-6519
J9 CURR OPIN CLIN NUTR
JI Curr. Opin. Clin. Nutr. Metab. Care
PD NOV
PY 2012
VL 15
IS 6
BP 553
EP 560
DI 10.1097/MCO.0b013e328358bdeb
PG 8
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 027OI
UT WOS:000310362000006
PM 23075934
DA 2025-06-11
ER

PT J
AU Johnson, LCM
   Bosque, L
   Jagtiani, A
   Barber, LE
   Gujral, UP
   Johnson, DA
AF Johnson, Leslie C. M.
   Bosque, Laura
   Jagtiani, Ashna
   Barber, Lauren E.
   Gujral, Unjali P.
   Johnson, Dayna A.
TI Attitudes and beliefs about sleep health among a racially and ethnically
   diverse sample of overweight/obese adults
SO SLEEP HEALTH
LA English
DT Article
DE Sleep barriers; Disparities; Cardiometabolic risk; Stress
ID INSUFFICIENT SLEEP; DURATION; QUALITY; DISPARITIES; HYGIENE; TRIAL
AB Objectives: To identify and compare how sleep-related attitudes and beliefs vary among racially and ethnically diverse adults with risk factors for cardio-metabolic disease.Methods: This exploratory qualitative study used online focus group discussions (N = 4 groups among 17 individuals) to collect information about sleep attitudes, beliefs, and practices following participation in the Mindfulness Intervention to Improve Sleep and Reduce Diabetes Risk Among a Diverse Sample in Atlanta (MINDS) study. A rapid analyses approach was used to identify shared themes related to attitudes and beliefs about sleep health and sleep practices across participants.Results: Participants on average were 31 years old, 88% female, and identified as Black/African American (52.9%), White (17.7%), Asian (11.8%), and Hispanic (17.7%). Three themes related to attitudes and beliefs about sleep health were identified: prioritization of sleep to improve one's overall health, re-evaluating sleep needs, and interpersonal barriers to sleep. For Black/African American participants prioritizing sleep was coupled with a want to minimize stress as a long-term health promotion strategy, whereas individuals of other races/ethnicities were more focused on the immediate benefits of getting sufficient sleep. Individuals had reappraised their sleep needs and worked to improve their sleep hygiene accordingly, yet still experienced barriers to sleep. The most common barrier to sleep was sharing a sleep environment with someone who had conflicting sleep routines and practices. Conclusion: The results of this study suggest perceived benefits of and barriers to sleep vary by race/ethnicity, thus future interventions should be culturally tailored to enhance effectiveness. (c) 2023 National Sleep Foundation. Published by Elsevier Inc. All rights reserved.
C1 [Johnson, Leslie C. M.] Emory Univ, Dept Family & Preventat Med, Emory Sch Med, Atlanta, GA USA.
   [Bosque, Laura; Barber, Lauren E.; Johnson, Dayna A.] Emory Univ, Rollins Sch Publ Hlth, Dept Epidemiol, Atlanta, GA USA.
   [Jagtiani, Ashna] Emory Univ, Emory Sch Med, Dept Pediat, Atlanta, GA USA.
   [Gujral, Unjali P.] Emory Univ, Rollins Sch Publ Hlth, Hubert Dept Global Hlth, Atlanta, GA USA.
   [Johnson, Leslie C. M.] Emory Univ, Emory Sch Med, Dept Family & Prevent Med, 1518 Clifton Rd NE, Atlanta, GA 30322 USA.
C3 Emory University; Emory University; Rollins School Public Health; Emory
   University; Emory University; Rollins School Public Health; Emory
   University
RP Johnson, LCM (corresponding author), Emory Univ, Emory Sch Med, Dept Family & Prevent Med, 1518 Clifton Rd NE, Atlanta, GA 30322 USA.
EM lmunoz@emory.edu
RI Johnson, Leslie/AAI-5472-2020; Gujral, Unjali/W-2640-2019;
   Johnson-Morgan, Dayna/HTM-2150-2023
OI Jagtiani, Ashna/0009-0006-8290-5277
FU Georgia Center for Diabetes Translation Research - National Institute of
   Diabetes and Digestive and Kidney Diseases (NIDDK) [P30DK111024];
   National Heart, Lung, and Blood Institute (NHLBI) [K01HL138211]
FX This work was supported in part by grant P30DK111024 from the Georgia
   Center for Diabetes Translation Research funded by the National
   Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) and the
   National Heart, Lung, and Blood Institute (NHLBI) K01HL138211.
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NR 34
TC 0
Z9 0
U1 0
U2 2
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2352-7218
EI 2352-7226
J9 SLEEP HEALTH
JI Sleep Health
PD DEC
PY 2023
VL 9
IS 6
BP 846
EP 851
DI 10.1016/j.sleh.2023.08.006
EA DEC 2023
PG 6
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA ED2K2
UT WOS:001136911400001
PM 37730475
DA 2025-06-11
ER

PT J
AU Phillips, SA
   Mahmoud, AM
   Brown, MD
   Haus, JM
AF Phillips, Shane A.
   Mahmoud, Abeer M.
   Brown, Michael D.
   Haus, Jacob M.
TI Exercise Interventions and Peripheral Arterial Function: Implications
   for Cardio-Metabolic Disease
SO PROGRESS IN CARDIOVASCULAR DISEASES
LA English
DT Review
DE Exercise; Peripheral Circulation; Endothelium; Hypertension; Obesity
ID ENDOTHELIAL NITRIC-OXIDE; C-REACTIVE PROTEIN; HUMAN SKELETAL-MUSCLE;
   BETA-CELL FUNCTION; BLOOD-PRESSURE REDUCTION; TYPE-2 DIABETIC-PATIENTS;
   VISCERAL ADIPOSE-TISSUE; FLOW-MEDIATED DILATION; SHORT-TERM EXERCISE;
   BODY-MASS INDEX
AB Physical inactivity is a major risk factor for the development of obesity and other cardiovascular (CV) disease (CVD). Vascular endothelial dysfunction is a key event in the development of CVD and is associated with a sedentary lifestyle in otherwise healthy adults. In addition, vascular endothelial dysfunction may be exacerbated in sedentary individuals who are obese and insulin resistant, since excess body fat is associated with elevated levels of pro-atherogenic inflammatory adipokines and cytokines that reduce the nitric oxide (NO) and other upstream paracrine signaling substances which reduces vascular health. Since blood flow-related shear stress is a major stimulus to NO release from the endothelium, disturbed flow or low shear stress is the likely mechanism by which vascular endothelial function is altered with inactivity. Evidence shows that regular physical exercise has beneficial effects on CVD and the risk factors that promote peripheral arterial function and health. Both aerobic and resistance exercise training are generally believed to improve endothelial function and are commonly recommended for CV health, including the management of obesity, hypertension, and insulin resistance. However, many factors including age, disease status, and race appear to influence these outcomes. Although evidence supporting the health benefits of exercise is compelling, the optimum prescription (volume and intensity) and the exact mechanism underlying the effects of exercise training on arterial function and cardiometabolic risk has yet to be identified. The focus of this review will be on the evidence supporting exercise interventions for peripheral arterial function. (C) 2014 Elsevier Inc. All rights reserved.
C1 [Phillips, Shane A.] Univ Illinois, Dept Phys Therapy, Chicago, IL 60612 USA.
   [Phillips, Shane A.; Mahmoud, Abeer M.; Brown, Michael D.; Haus, Jacob M.] Univ Illinois, Coll Appl Hlth Sci, Integrat Physiol Lab, Chicago, IL 60612 USA.
   [Mahmoud, Abeer M.; Brown, Michael D.; Haus, Jacob M.] Univ Illinois, Dept Kinesiol & Nutr, Chicago, IL 60612 USA.
C3 University of Illinois System; University of Illinois Chicago;
   University of Illinois Chicago Hospital; University of Illinois System;
   University of Illinois Chicago; University of Illinois Chicago Hospital;
   University of Illinois System; University of Illinois Chicago;
   University of Illinois Chicago Hospital
RP Phillips, SA (corresponding author), Univ Illinois, Coll Appl Hlth Sci, Dept Phys Therapy, 1919 W Taylor St MC 898, Chicago, IL 60612 USA.
EM shanep@uic.edu
OI Haus, Jacob/0000-0002-8048-2470; Phillips, Shane/0000-0001-6030-2367
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NR 162
TC 61
Z9 74
U1 0
U2 33
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0033-0620
EI 1873-1740
J9 PROG CARDIOVASC DIS
JI Prog. Cardiovasc. Dis.
PD MAR-APR
PY 2015
VL 57
IS 5
BP 521
EP 534
DI 10.1016/j.pcad.2014.12.005
PG 14
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA CE4NP
UT WOS:000351807600013
PM 25529367
DA 2025-06-11
ER

PT J
AU Saleh, FL
   Starkman, H
   Furness, A
   Pfeifer, SM
   Kives, S
AF Saleh, Farrah L.
   Starkman, Hava
   Furness, Allison
   Pfeifer, Samantha M.
   Kives, Sari
TI Polycystic Ovary Syndrome in Adolescents
SO OBSTETRICS AND GYNECOLOGY CLINICS OF NORTH AMERICA
LA English
DT Article
DE PCOS; Adolescent anovulation; Polycystic ovary syndrome
ID SYNDROME PCOS; DIAGNOSTIC-CRITERIA; INSULIN-RESISTANCE; GRANULOSA-CELLS;
   HORMONE; GIRLS; HYPERANDROGENISM; PREVALENCE; DEPRESSION; MODULATION
AB PCOS is a heterogeneous endocrinologic disorder that is characterized by oligomenorrhea or amenorrhea and signs of hyperandrogenism. The cause of PCOS remains unknown, but the syndrome is associated with IR that in turn leads to hyperandrogenism. An accurate and prompt diagnosis of PCOS is important to understanding an adolescent's risk. In adolescents, both oligoovulation and hyperandrogenism are needed for the diagnosis of PCOS and ultrasound is not recommended. Lifelong health consequences of PCOS are significant and include obesity, diabetes, metabolic syndrome, and anovulatory infertility. The symptoms of PCOS can be disturbing to an adolescent girl. Early diagnosis and intervention are therefore important to treat these symptoms and prevent the long-term sequelae. Current treatment regimens target the specific symptoms of PCOS. These include weight management/reduction programs for obese adolescents and hormonal contraceptives and antiandrogens for menstrual irregularity, hirsutism, and acne. Insulin-sensitizing agents are promising in those with IR, but randomized controlled trials are needed to determine the long-term risks and benefits as well as efficacy over traditional therapies before using as first- line therapy.
C1 [Saleh, Farrah L.; Pfeifer, Samantha M.] Cornell Univ, New York Presbyterian Hosp, Weill Med Coll, Div Reprod Endocrinol & Infertil, New York, NY USA.
   [Starkman, Hava] Univ Toronto, Toronto, ON, Canada.
   [Furness, Allison] Dalhousie Univ, Halifax, NS, Canada.
   [Kives, Sari] Univ Toronto, Hosp Sick Children, Div Pediat Gynecol, Toronto, ON, Canada.
C3 Cornell University; Weill Cornell Medicine; NewYork-Presbyterian
   Hospital; University of Toronto; Dalhousie University; University of
   Toronto; Hospital for Sick Children (SickKids)
RP Kives, S (corresponding author), Hosp Sick Children, 170 Elizabeth St Black Wing, Toronto, ON M5G 2L3, Canada.
EM kivess@rogers.com
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NR 69
TC 0
Z9 0
U1 2
U2 2
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0889-8545
EI 1558-0474
J9 OBSTET GYN CLIN N AM
JI Obstet. Gynecol. Clin. N. Am.
PD DEC
PY 2024
VL 51
IS 4
BP 679
EP 693
DI 10.1016/j.ogc.2024.08.005
EA NOV 2024
PG 15
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA L5O6K
UT WOS:001351214500001
PM 39510738
DA 2025-06-11
ER

PT J
AU Cao, RY
   Zheng, YT
   Zhang, Y
   Jiang, LL
   Li, Q
   Sun, WQ
   Gu, WQ
   Cao, WF
   Zhou, LY
   Zheng, HC
   Yang, J
AF Cao, Richard Y.
   Zheng, Yuntao
   Zhang, Ying
   Jiang, Lingling
   Li, Qing
   Sun, Wanqun
   Gu, Wenqin
   Cao, Weifeng
   Zhou, Linyan
   Zheng, Hongchao
   Yang, Jian
TI Berberine on the Prevention and Management of Cardiometabolic Disease:
   Clinical Applications and Mechanisms of Action
SO AMERICAN JOURNAL OF CHINESE MEDICINE
LA English
DT Article
DE Berberine; Herbal Medicine; Heart; Cardiometabolic Disease; Mechanism;
   Review
ID IMPROVES ENDOTHELIAL FUNCTION; ISCHEMIA-REPERFUSION INJURY;
   CONGESTIVE-HEART-FAILURE; ACTIVATED RECEPTOR-GAMMA; CARDIAC DYSFUNCTION;
   OXIDATIVE STRESS; P-GLYCOPROTEIN; NUTRACEUTICAL COMBINATION;
   INTESTINAL-ABSORPTION; MYOCARDIAL-INFARCTION
AB Berberine is an alkaloid from several medicinal plants originally used to treat diarrhea and dysentery as a traditional Chinese herbal medicine. In recent years, berberine has been discovered to exhibit a wide spectrum of biological activities in the treatment of diverse diseases ranging from cancer and neurological dysfunctions to metabolic disorders and heart diseases. This review article summarizes the clinical practice and laboratory exploration of berberine for the treatment of cardiometabolic and heart diseases, with a focus on the novel insights and recent advances of the underlying mechanisms recognized in the past decade. Berberine was found to display pleiotropic therapeutic effects against dyslipidemia, hyperglycemia, hypertension, arrhythmia, and heart failure. The mechanisms of berberine for the treatment of cardiometabolic disease involve combating inflammation and oxidative stress such as inhibiting proprotein convertase subtilisin/kexin 9 (PCSK9) activation, regulating electrical signals and ionic channels such as targeting human ether-a-go-go related gene (hERG) currents, promoting energy metabolism such as activating adenosine monophosphate-activated protein kinase (AMPK) signaling pathway, modifying gut microbiota to promote transforming of berberine into its intestine-absorbable form, and interacting with non-coding RNAs via targeting multiple signaling pathways such as AMPK, mechanistic target of rapamycin (mTOR), etc. Collectively, berberine appears to be safe and well-tolerated in clinical practice, especially for those who are intolerant to statins. Knowledge from this field may pave the way for future development of more effective pharmaceutical approaches for managing cardiometabolic risk factors and preventing heart diseases.
C1 [Cao, Richard Y.; Zheng, Yuntao; Zhang, Ying; Jiang, Lingling; Li, Qing; Sun, Wanqun; Zheng, Hongchao; Yang, Jian] Fudan Univ, Shanghai Xuhui Cent Hosp, CVD Collaborat Program, Shanghai 200031, Peoples R China.
   [Zheng, Yuntao] Shanghai Univ Tradit Chinese Med, Longhua Hosp, CVD Collaborat Program, Shanghai 200032, Peoples R China.
   [Gu, Wenqin; Cao, Weifeng] Shanghai Xuhui Fengling Community Healthcare Serv, Dept Rehabil, Shanghai 200032, Peoples R China.
   [Zhou, Linyan] Shanghai Xuhui Caohejing Community Healthcare Ser, Dept Rehabil, Shanghai 200235, Peoples R China.
C3 Fudan University; Shanghai University of Traditional Chinese Medicine
RP Cao, RY; Zheng, HC; Yang, J (corresponding author), Fudan Univ, Shanghai Xuhui Cent Hosp, 966 Middle Huaihai Rd, Shanghai 200031, Peoples R China.
EM rycao@scrc.ac.cn; hczheng@scrc.ac.cn; jyang@scrc.ac.cn
RI Li, Wencai/JWO-1187-2024; Zhou, Linyan/MXM-0733-2025; lin,
   Lynn/GQQ-8446-2022
FU National Natural Science Foundation of China [81973612]; Shanghai
   Municipal Health Commission [ZK2019A11, ZK2019A10]
FX This work was supported by the National Natural Science Foundation of
   China [grant number 81973612 to YZ]; Shanghai Municipal Health
   Commission [grant numbers ZK2019A11 and ZK2019A10 to HZ and JY,
   respectively]. The authors would like to express their gratitude to Yang
   Xi and Shuangshuang Yang from Shanghai Xuhui Central Hospital for
   reference collection as well as Yanrong Lu from Qibao Community
   Healthcare Service Center for graphical assistance.
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NR 98
TC 15
Z9 18
U1 4
U2 31
PU WORLD SCIENTIFIC PUBL CO PTE LTD
PI SINGAPORE
PA 5 TOH TUCK LINK, SINGAPORE 596224, SINGAPORE
SN 0192-415X
EI 1793-6853
J9 AM J CHINESE MED
JI Am. J. Chin. Med.
PY 2021
VL 49
IS 07
BP 1645
EP 1666
DI 10.1142/S0192415X21500762
PG 22
WC Integrative & Complementary Medicine; Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine; General & Internal Medicine
GA XA0GS
UT WOS:000720336900004
PM 34488551
DA 2025-06-11
ER

PT J
AU Perry, BI
   Salimkumar, D
   Green, D
   Meakin, A
   Gibson, A
   Mahajan, D
   Tahir, T
   Singh, SP
AF Perry, Benjamin I.
   Salimkumar, Dhanya
   Green, Daniel
   Meakin, Anne
   Gibson, Andrew
   Mahajan, Deepali
   Tahir, Tayyeb
   Singh, Swaran P.
TI Associated illness severity in schizophrenia and diabetes mellitus: A
   systematic review
SO PSYCHIATRY RESEARCH
LA English
DT Review
DE Schizophrenia; Psychotic disorders; Diabetes mellitus; Inflammation
ID BRAIN-BARRIER PERMEABILITY; C-REACTIVE PROTEIN; METABOLIC SYNDROME;
   INSULIN-RESISTANCE; BIPOLAR DISORDER; PSYCHOSIS; INFLAMMATION;
   PERFORMANCE; DEPRESSION; LIFE
AB Objective: We aimed to elucidate whether schizophrenia and type II diabetes mellitus may present with associated illness severity, in light of accumulating evidence to suggest both conditions have important shared inflammatory components with many shared inflammatory genetic factors.
   Methods: We conducted a systematic review employing PRISMA criteria, searching EMBASE, Ovid MEDLINE, Psychlnfo, Web of Science and Google Scholar to February 1st, 2017, for clinical studies assessing schizophrenia severity alongside dysglycaemia. A narrative synthesis was employed to discuss and compare findings between studies.
   Results: Eleven observational studies were included in the analysis. Ten presented evidence in support of an association between schizophrenia severity and dysglycaemia. This association appeared particularly strong regarding negative symptomatology and impaired cognitive function, between which there may be some overlap. Studies examining positive symptomatology returned mixed results.
   Conclusion: Whilst study design varied amongst the included studies, the results suggest that further work examining the effect of hyperglycaemia on schizophrenia severity may be relevant, particularly longitudinal studies assessing negative symptomatology and cognitive function. To the authors' knowledge, this is the first systematic review conducted to address this question.
C1 [Perry, Benjamin I.; Singh, Swaran P.] Univ Warwick, Dept Mental Hlth & Wellbeing, Coventry, W Midlands, England.
   [Perry, Benjamin I.; Gibson, Andrew; Singh, Swaran P.] Coventry & Warwickshire Partnership NHS Trust, Coventry, W Midlands, England.
   [Salimkumar, Dhanya; Green, Daniel; Meakin, Anne] Univ Warwick, Warwick Med Sch, Coventry, W Midlands, England.
   [Mahajan, Deepali; Tahir, Tayyeb] Cardiff & Vale NHS Trust, Cardiff, S Glam, Wales.
C3 University of Warwick; University of Warwick; Cardiff University
RP Perry, BI (corresponding author), Coventry & Warwickshire Partnership NHS Trust, Caludon Ctr, Coventry CV2 2TE, W Midlands, England.
EM Benjamin.perry@covwarkpt.nhs.uk
OI Perry, Benjamin I./0000-0002-1533-026X; Gibson, Andy/0000-0001-6730-4162
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NR 41
TC 20
Z9 21
U1 0
U2 4
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0165-1781
EI 1872-7123
J9 PSYCHIAT RES
JI Psychiatry Res.
PD OCT
PY 2017
VL 256
BP 102
EP 110
DI 10.1016/j.psychres.2017.06.027
PG 9
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA FJ5JL
UT WOS:000412787700016
PM 28628790
OA Green Published
DA 2025-06-11
ER

PT J
AU Donovan, NJ
   Blazer, D
AF Donovan, Nancy J.
   Blazer, Dan
TI Social Isolation and Loneliness in Older Adults: Review and Commentary
   of a National Academies Report
SO AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
LA English
DT Review
DE Social isolation; loneliness; social connection; social support; social
   integration; healthcare policy
ID CORONARY-HEART-DISEASE; TRAINING REDUCES LONELINESS; CROSS-LAGGED
   ANALYSES; C-REACTIVE PROTEIN; RISK-FACTORS; EMOTIONAL LONELINESS;
   METABOLIC SYNDROME; MORTALITY; HEALTH; DEPRESSION
AB The authors of this review both served on the National Academy of Science, Engineering, and Medicine Committee that produced the report, "Social Isola-tion and Loneliness in Older Adults: Opportunities for the Health Care System." In 2018, the AARP Foundation commissioned the National Academies to establish a committee to research and develop a report on social isolation and loneliness in persons 50 years of age and older. Emphasis was placed upon the role of the healthcare system in addressing this fundamental public health problem. The committee released the report in February 2020 as the Corona Virus Disease 2019 pandemic was beginning to spread to North America. In this review, the authors share central findings and conclusions from the report as well as how these findings may be relevant to the care and well-being of older adults during this historic pandemic. The health protective benefits of social distancing must be balanced by the essential need for sustaining social relationships.
C1 [Donovan, Nancy J.] Brigham & Womens Hosp, Dept Psychiat, Div Geriatr Psychiat, Boston, MA USA.
   [Donovan, Nancy J.] Brigham & Womens Hosp, Dept Neurol, Boston, MA USA.
   [Donovan, Nancy J.] Harvard Med Sch, Massachusetts Gen Hosp, Dept Psychiat, Boston, MA USA.
   [Blazer, Dan] Duke Univ, Dept Psychiat & Behav Sci, Med Ctr, Durham, NC 27513 USA.
C3 Harvard University; Harvard University Medical Affiliates; Brigham &
   Women's Hospital; Harvard University; Harvard University Medical
   Affiliates; Brigham & Women's Hospital; Harvard University; Harvard
   Medical School; Harvard University Medical Affiliates; Massachusetts
   General Hospital; Duke University
RP Blazer, D (corresponding author), Duke Univ, Med Ctr, 203 Midenhall Way Cary, Durham, NC 27513 USA.
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NR 97
TC 308
Z9 342
U1 11
U2 91
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1064-7481
EI 1545-7214
J9 AM J GERIAT PSYCHIAT
JI Am. J. Geriatr. Psychiatr.
PD DEC
PY 2020
VL 28
IS 12
BP 1233
EP 1244
DI 10.1016/j.jagp.2020.08.005
PG 12
WC Geriatrics & Gerontology; Gerontology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Psychiatry
GA OQ2KS
UT WOS:000588619000001
PM 32919873
OA Green Published
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Okuro, M
   Morimoto, S
AF Okuro, Masashi
   Morimoto, Shigeto
TI Sleep apnea in the elderly
SO CURRENT OPINION IN PSYCHIATRY
LA English
DT Review
DE continuous positive airway pressure; elderly; Epworth sleepiness scale;
   international classification of sleep disorders 3; sleep apnea syndrome
ID POSITIVE AIRWAY PRESSURE; CARDIOVASCULAR MORTALITY; AMERICAN ACADEMY;
   BLOOD-PRESSURE; HEART-FAILURE; RISK; HYPERTENSION; STROKE; CPAP;
   RECOMMENDATIONS
AB Purpose of review
   Sleep apnea syndrome (SAS) in the elderly presents varied clinical symptoms and also has many complications. Moreover, there are many hospital departments related to these symptoms. This article uses literature to provide an outline on SAS observed in the elderly.
   Recent findings
   SAS sufferers often have complications with so-called lifestyle-related diseases, such as hypertension, hyperlipidemia, diabetes mellitus and metabolic syndrome. These symptoms, along with SAS, recede as a result of continuous positive airway pressure treatment. Some have also reported recession of depression symptoms and delay in deterioration of cognitive functions.
   Summary
   The elderly tends to develop SAS through coexistence of chronic respiratory organ disorders, increase in upper airway collapse, strokes, cardiovascular diseases, hypertension, diabetes mellitus and other physiological anatomical changes that accompany aging. However, judgment on the severity and effects regarding prognosis by each remedy used in the diagnosis and treatment of SAS in the elderly is still being developed, and it is considered necessary to accumulate more evidence and establish new standards.
C1 [Okuro, Masashi; Morimoto, Shigeto] Kanazawa Med Univ, Dept Geriatr Med, Uchinadamachi, Ishikawa Prefec 9200293, Japan.
C3 Kanazawa Medical University
RP Okuro, M (corresponding author), Kanazawa Med Univ, Dept Geriatr Med, 1-1 Daigaku, Uchinadamachi, Ishikawa Prefec 9200293, Japan.
EM okuro@kanazawa-med.ac.jp
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NR 42
TC 9
Z9 11
U1 0
U2 17
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0951-7367
EI 1473-6578
J9 CURR OPIN PSYCHIATR
JI Curr. Opin. Psychiatr.
PD NOV
PY 2014
VL 27
IS 6
BP 472
EP 477
DI 10.1097/YCO.0000000000000105
PG 6
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA AQ8AM
UT WOS:000343042700015
PM 25211498
DA 2025-06-11
ER

PT J
AU Pölönen, J
   Pinola, P
   Ronkainen, J
   Blakemore, A
   Buxton, JL
   Tapanainen, JS
   Franks, S
   Piltonen, TT
   Sebert, S
   Morin-Papunen, L
AF Polonen, Johanna
   Pinola, Pekka
   Ronkainen, Justiina
   Blakemore, Alex, I
   Buxton, Jessica L.
   Tapanainen, Juha S.
   Franks, Stephen
   Piltonen, Terhi T.
   Sebert, Sylvain
   Morin-Papunen, Laure
TI Polycystic ovary syndrome and leukocyte telomere length: cross-sectional
   and longitudinal changes
SO EUROPEAN JOURNAL OF ENDOCRINOLOGY
LA English
DT Article
ID OLIGOMENORRHEA AND/OR HIRSUTISM; SELF-REPORTED SYMPTOMS; OXIDATIVE
   STRESS; SYNDROME PCOS; CARDIOVASCULAR-DISEASE; FOLLOW-UP; WOMEN;
   OBESITY; WEIGHT; SUSCEPTIBILITY
AB ObjectiveTelomeres are DNA-protein complexes that protect chromosome ends from DNA damage and are surrogate biomarkers of cellular aging. Current evidence, almost entirely from cross-sectional observations, supports negative associations between leukocyte telomere length (LTL) and adverse lifestyle factors and cardiometabolic risk factors. Polycystic ovary syndrome (PCOS), the most common gynecological endocrine disorder, is associated with inflammation and oxidative stress, both factors associated with accelerated telomere attrition. We therefore hypothesized that LTL would be shorter and decrease more rapidly in women with PCOS in comparison to a control population. DesignThis is a population-based cohort study comprising women of Northern Finland Birth Cohort 1966, with clinical examinations at ages 31 and 46. The sample included self-reported PCOS (age 31, n = 190; age 46, n = 207) and referent women (age 31, n = 1054; age 46, n = 1324) with data on LTL. MethodsThe association between LTL and PCOS at ages 31 and 46 was analyzed by linear regression models adjusted for BMI, smoking, alcohol consumption and socioeconomic status at the corresponding age. ResultsWomen with PCOS had similar mean LTL at ages 31 and 46 (P > 0.4 for both). The mean LTL change between ages 31 and 46 did not differ between groups (P = 0.19). However, we observed a significant LTL attrition between ages 31 and 46 in the reference population (P < 0.001), but not in women with PCOS (P = 0.96). ConclusionsThis finding may suggest a difference in the LTL attrition rate in women with PCOS, an unexpected finding that might affect their risk of age-related disease. Further research is needed to clarify the underlying mechanisms.
C1 [Polonen, Johanna; Pinola, Pekka; Tapanainen, Juha S.; Piltonen, Terhi T.; Morin-Papunen, Laure] Univ Oulu, Dept Obstet & Gynecol, Oulu, Finland.
   [Polonen, Johanna; Pinola, Pekka; Tapanainen, Juha S.; Piltonen, Terhi T.; Morin-Papunen, Laure] Oulu Univ Hosp, Med Res Ctr, PEDEGO Res Unit, Oulu, Finland.
   [Ronkainen, Justiina; Sebert, Sylvain] Univ Oulu, Ctr Life Course Hlth Res, Oulu, Finland.
   [Blakemore, Alex, I] Brunel Univ London, Coll Hlth Med & Life Sci, Dept Life Sci, London, England.
   [Blakemore, Alex, I] Imperial Coll London, Dept Metab Digest & Reprod, London, England.
   [Buxton, Jessica L.] Kingston Univ London, Sch Life Sci Pharm & Chem, Dept Biomol Sci, London, England.
   [Tapanainen, Juha S.] Univ Helsinki, Dept Obstet & Gynecol, Helsinki, Finland.
   [Tapanainen, Juha S.] Helsinki Univ Hosp, Helsinki, Finland.
   [Franks, Stephen] Imperial Coll London, Inst Reprod & Dev Biol, Dept Metab Digest & Reprod, London, England.
C3 University of Oulu; University of Oulu; University of Oulu; Brunel
   University; Imperial College London; Kingston University; University of
   Helsinki; University of Helsinki; Helsinki University Central Hospital;
   Imperial College London
RP Pinola, P (corresponding author), Univ Oulu, Dept Obstet & Gynecol, Oulu, Finland.; Pinola, P (corresponding author), Oulu Univ Hosp, Med Res Ctr, PEDEGO Res Unit, Oulu, Finland.; Franks, S (corresponding author), Imperial Coll London, Inst Reprod & Dev Biol, Dept Metab Digest & Reprod, London, England.
EM pekka.pinola@oulu.fi; s.franks@imperial.ac.uk
RI Pinola, Pekka/HSF-3027-2023; Piltonen, Terhi/CAH-4447-2022; Buxton,
   Jess/IUB-6294-2023; Blakemore, Alexandra/D-2253-2009
OI Piltonen, Terhi/0000-0002-9921-7300; Blakemore,
   Alexandra/0000-0003-0661-564X; Pinola, Pekka/0000-0001-6356-723X;
   Franks, Stephen/0000-0002-3712-0335; Ronkainen,
   Justiina/0000-0001-7375-8099
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NR 65
TC 4
Z9 4
U1 0
U2 1
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0804-4643
EI 1479-683X
J9 EUR J ENDOCRINOL
JI Eur. J. Endocrinol.
PD NOV 1
PY 2022
VL 187
IS 5
BP 651
EP 661
DI 10.1530/EJE-22-0462
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 8G7TU
UT WOS:000920547300009
PM 36074951
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Ji, S
   Zang, Z
   Ma, H
   Gu, M
   Han, Y
   Wang, L
   Jia, S
   Yang, B
AF Ji, S.
   Zang, Z.
   Ma, H.
   Gu, M.
   Han, Y.
   Wang, L.
   Jia, S.
   Yang, B.
TI Erectile dysfunction in patients with plaque psoriasis: the relation of
   depression and cardiovascular factors
SO INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH
LA English
DT Article
ID QUALITY-OF-LIFE; SEXUAL DYSFUNCTION; METABOLIC SYNDROME; RISK; DISEASE;
   METAANALYSIS; POPULATION; OBESITY; PREVALENCE; PREDICTION
AB Psoriasis is a chronic inflammatory skin disease and seems to be associated with erectile dysfunction (ED). ED is a predictor of future cardiovascular disease. It is important to identify ED early and investigate cardiovascular problems in psoriasis patients. The sample consisted of 191 psoriasis patients and 191 healthy men. One hundred and one of 191 (52.9%) patients with psoriasis were indicative of ED, compared with 40.3% in control group, reflecting an age-adjusted odds ratio of 1.965 in favor of the psoriasis group. A univariate analysis in the psoriasis group indicated that age, hypertension, hyperlipidemia, diabetes mellitus and depressive symptoms were the risk factors for ED. The multivariate logistic regression model indicated that increasing age, hypertension, hyperlipidemia and depressive symptoms were independent risk factors for ED in psoriasis. The more severe depressive symptoms increased the risk of ED and especially moderate-severe ED. The diagnosis of ED may help prevent emotional and physical discomfort in men and aid in identifying reversible cardiovascular risk factors. Screening of ED may become a part of routine care in the management of psoriasis patients.
C1 [Ji, S.; Gu, M.; Yang, B.] Guangdong Prov Dermatol Hosp, Dept Dermatol, Lujing Rd 2, Guangzhou 510091, Guangdong, Peoples R China.
   [Zang, Z.] Sun Yat Sen Univ, Affiliated Hosp 3, Dept Infertil & Sexual Med, Guangzhou 510275, Guangdong, Peoples R China.
   [Ma, H.] Sun Yat Sen Univ, Affiliated Hosp 3, Dept Dermatol, Guangzhou 510275, Guangdong, Peoples R China.
   [Han, Y.] Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Dermatol, Guangzhou 510275, Guangdong, Peoples R China.
   [Wang, L.] Guangzhou Med Univ, Guangfo Hosp, Dept Dermatol, Foshan, Peoples R China.
   [Jia, S.] Guangzhou Nansha Cent Hosp, Dept Dermatol, Guangzhou, Guangdong, Peoples R China.
C3 Southern Medical University - China; Sun Yat Sen University; Sun Yat Sen
   University; Sun Yat Sen University; Guangzhou Medical University
RP Yang, B (corresponding author), Guangdong Prov Dermatol Hosp, Dept Dermatol, Lujing Rd 2, Guangzhou 510091, Guangdong, Peoples R China.
EM binyang101@163.com
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NR 35
TC 29
Z9 32
U1 0
U2 15
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0955-9930
EI 1476-5489
J9 INT J IMPOT RES
JI Int. J. Impot. Res.
PD MAY-JUN
PY 2016
VL 28
IS 3
BP 96
EP 100
DI 10.1038/ijir.2016.6
PG 5
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA DL5SY
UT WOS:000375698400003
PM 26865100
OA Bronze
DA 2025-06-11
ER

PT J
AU Seppänen, E
   Kuukka, H
   Voutilainen, A
   Huuskonen, H
   Peuhkuri, N
AF Seppanen, E.
   Kuukka, H.
   Voutilainen, A.
   Huuskonen, H.
   Peuhkuri, N.
TI Metabolic depression and spleen and liver enlargement in juvenile Arctic
   charr Salvelinus alpinus exposed to chronic parasite infection
SO JOURNAL OF FISH BIOLOGY
LA English
DT Article
DE Diplostomum spp; liver; Salvelinus alpinus; spleen; standard metabolic
   rate
ID NONALCOHOLIC FATTY LIVER; IMMUNE DEFENSE; SEXUAL ORNAMENTATION; SPECIES
   RICHNESS; ATLANTIC SALMON; RAINBOW-TROUT; AVIAN SPLEEN; INBRED-LINES;
   TEMPERATURE; SYSTEM
AB The present study on the connection between standard metabolic rate (R(S)) and chronic Diplostomum spp. infection resulted in a decrease in R(S), and an enlargement in spleen and liver sizes in the infected juvenile Arctic charr Salvelinus alpinus compared to control fish. As splenic enlargement observed in infected fish was not due to condition-related changes in the spleen, it could most probably be explained by increased leucocyte synthesis. The higher liver masses in infected S. alpinus may have been related to disorders in energetic function, which could have had major effects on biochemical regulation by the liver. The proposed metabolic syndrome with a possible reduction in insulin sensitivity in tissues results in ineffective glucose and lipid metabolism and thus it is suggested that chronic Diplostomum infection in S. alpinus might not impose direct energetic costs, but it may weaken the efficiency of energy metabolism and thus lead to lowered R(S).
C1 [Seppanen, E.] FGFRI, FI-58175 Enonkoski, Finland.
   [Kuukka, H.] Univ Helsinki, Dept Ecol & Environm Sci, Integrat Ecol Unit, FI-00014 Helsinki, Finland.
   [Voutilainen, A.; Huuskonen, H.] Univ Joensuu, Inst Ecol Res, Fac Biosci, FI-80101 Joensuu, Finland.
   [Kuukka, H.; Peuhkuri, N.] FGFRI, FI-48100 Kotka, Finland.
C3 University of Helsinki; University of Eastern Finland
RP Seppänen, E (corresponding author), FGFRI, Laasalantie 9, FI-58175 Enonkoski, Finland.
EM eila.seppanen@rktl.fi
RI Peuhkuri, Nina/M-9662-2018
OI Peuhkuri, Nina/0000-0002-0301-282X; Huuskonen, Hannu/0000-0001-5609-768X
FU Finnish Game and Fisheries Research Institute; Nordic Workgroup for
   Fisheries; Graduate School in Biological Interactions
FX We thank Saimaa Fisheries Research and Aquaculture for providing fish
   and excellent working facilities. We also thank T. Nurmio, T. Heikkinen
   and E. Hirvonen for giving a hand in experimental arrangements. The
   research was funded by the Finnish Game and Fisheries Research
   Institute, the Nordic Workgroup for Fisheries (H.K. and N.P.) and the
   Graduate School in Biological Interactions (A.V.).
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NR 50
TC 48
Z9 53
U1 1
U2 18
PU WILEY-BLACKWELL PUBLISHING, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0022-1112
J9 J FISH BIOL
JI J. Fish Biol.
PD FEB
PY 2009
VL 74
IS 3
BP 553
EP 561
DI 10.1111/j.1095-8649.2008.02144.x
PG 9
WC Fisheries; Marine & Freshwater Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Fisheries; Marine & Freshwater Biology
GA 402VB
UT WOS:000263040100005
PM 20735578
DA 2025-06-11
ER

PT J
AU Zuniga, JA
   Wright, C
   Fordyce, J
   Ohueri, CW
   Garciá, AA
AF Zuniga, Julie A.
   Wright, Charlotte
   Fordyce, Jonathan
   Ohueri, Chelsi West
   Garcia, Alexandra A.
TI Self-Management of HIV and Diabetes in African American Women: A
   Systematic Review of Qualitative Literature
SO DIABETES EDUCATOR
LA English
DT Review
ID INSULIN-RESISTANCE; METABOLIC SYNDROME; SOCIAL SUPPORT; SPIRITUALITY;
   EXPERIENCES; PREVALENCE; STATES; LIVES; RISK; CARE
AB Purpose The purpose of this systematic review of qualitative literature was (1) to identify self-management strategies, (2) to identify women's barriers to self-management, and (3) to compare self-management strategies of diabetes and human immunodeficiency virus (HIV). African American women living with HIV are at high risk for developing diabetes because of genetics, lifestyle, and HIV treatment. Self-management of each of these conditions is critical to decrease morbidity and mortality.
   Conclusions A literature search resulted in 15 articles: 10 on the topic of HIV and 5 on diabetes. Self-management strategies included spirituality, family and social support, and indulgent self-care. Barriers included depression, stigma, and the role of caregiver. The themes identified for HIV and diabetes self-care barriers and facilitators were exceptionally similar. Themes of spirituality, family support, and indulgent self-care were part of both HIV and diabetes self-care. Women with HIV were less concerned with their independence than women with diabetes, and focused on disclosure of their HIV status and development of a support system.
C1 [Zuniga, Julie A.; Wright, Charlotte; Fordyce, Jonathan; Garcia, Alexandra A.] Univ Texas Austin, Sch Nursing, 1710 Red River, Austin, TX 78701 USA.
   [Ohueri, Chelsi West] Univ Texas Austin, Sch Med, Austin, TX 78712 USA.
C3 University of Texas System; University of Texas Austin; University of
   Texas System; University of Texas Austin
RP Zuniga, JA (corresponding author), Univ Texas Austin, Sch Nursing, 1710 Red River, Austin, TX 78701 USA.
EM jzuniga@nursing.utexas.edu
RI Huang, Ya-Ching/AAW-3245-2021
OI Ohueri, Chelsi/0000-0002-5192-2596
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NR 33
TC 10
Z9 12
U1 1
U2 12
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0145-7217
EI 1554-6063
J9 DIABETES EDUCATOR
JI Diabetes Educ.
PD OCT
PY 2018
VL 44
IS 5
BP 419
EP 434
DI 10.1177/0145721718794879
PG 16
WC Endocrinology & Metabolism; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Public, Environmental & Occupational Health
GA GU1AI
UT WOS:000444986400001
PM 30146937
DA 2025-06-11
ER

PT J
AU Fernandez-Mendoza, J
AF Fernandez-Mendoza, Julio
TI The insomnia with short sleep duration phenotype: an update on it's
   importance for health and prevention
SO CURRENT OPINION IN PSYCHIATRY
LA English
DT Review
DE insomnia; morbidity; mortality; short sleep duration; treatment
ID PITUITARY-ADRENAL AXIS; CARDIOVASCULAR EVENTS; METABOLIC SYNDROME;
   SYMPTOMS; HYPERTENSION; HYPERAROUSAL; ASSOCIATIONS; PREVALENCE;
   DEPRESSION; MANAGEMENT
AB Purpose of reviewIt was first proposed in the late 1990s that objective markers of sleep disturbance could serve as an index of the biological severity of insomnia. In 2013, a heuristic model of two insomnia phenotypes based on objective sleep duration was proposed. Herein, we review the studies conducted in the past 3 years on the insomnia with short sleep duration phenotype and its implications for a clinical research agenda.Recent findingsStudies have shown that insomnia with objective short sleep duration is associated with physiologic hyperarousal and cardiometabolic and neurocognitive morbidity, whereas insomnia with normal sleep duration is not. Both insomnia phenotypes are associated with psychiatric morbidity albeit through different psychobiological mechanisms. Novel recent studies have included occupational outcomes, developmental approaches, at-home objective sleep testing, diagnostic accuracy measures, and response to cognitive-behavioral treatment.SummaryAccumulating evidence in the past years has continued to support that insomnia with short sleep duration is a more severe phenotype of the disorder associated with physiologic changes, significant morbidity and mortality and, potentially, a differential response to treatment.
C1 [Fernandez-Mendoza, Julio] Penn State Univ, Sleep Res & Treatment Ctr, Penn State Milton S Hershey Med Ctr, Coll Med, 500 Univ Dr H073, Hershey, PA 17033 USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE);
   Pennsylvania State University; Penn State Health
RP Fernandez-Mendoza, J (corresponding author), Penn State Univ, Sleep Res & Treatment Ctr, Penn State Milton S Hershey Med Ctr, Coll Med, 500 Univ Dr H073, Hershey, PA 17033 USA.
EM jfernandezmendoza@hmc.psu.edu
RI Fernandez-Mendoza, Julio/AAH-8128-2021
OI Fernandez-Mendoza, Julio/0000-0001-9584-6161
FU American Heart Association [14SDG19830018]; American Heart Association
   (AHA) [14SDG19830018] Funding Source: American Heart Association (AHA)
FX Part of the effort put on this review was supported by the American
   Heart Association (14SDG19830018).
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NR 59
TC 71
Z9 75
U1 0
U2 13
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0951-7367
EI 1473-6578
J9 CURR OPIN PSYCHIATR
JI Curr. Opin. Psychiatr.
PD JAN
PY 2017
VL 30
IS 1
BP 56
EP 63
DI 10.1097/YCO.0000000000000292
PG 8
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA EF3RI
UT WOS:000390241700010
PM 27764017
DA 2025-06-11
ER

PT J
AU Barbosa, IG
   Huguet, RB
   Neves, FS
   Reis, HJ
   Bauer, ME
   Janka, Z
   Palotás, A
   Teixeira, AL
AF Barbosa, Izabela Guimaraes
   Huguet, Rodrigo Barreto
   Neves, Fernando Silva
   Reis, Helton Jose
   Bauer, Moises Evandro
   Janka, Zoltan
   Palotas, Andras
   Teixeira, Antonio Lucio
TI Impaired nerve growth factor homeostasis in patients with bipolar
   disorder
SO WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
LA English
DT Article
DE Biomarker; bipolar disorder; nerve growth factor (NGF); neuroplasticity;
   neurotrophin
ID NEUROTROPHIC FACTORS; METABOLIC SYNDROME; PATHOPHYSIOLOGY; RECEPTORS;
   OBESITY
AB Objective. Neuro-trophins are critically involved in neuro-plasticity, the impairment of which is a major role-player in bipolar disorder (BD), and their altered levels have been recently advocated in the patho-physiology of this affective malady. The aim of this study, therefore, was to evaluate the plasma levels of nerve growth factor (NGF) in BD patients in comparison with control subjects. Methods. Forty-nine BD type-I individuals (30 in mania and 19 in euthymia) and 36 healthy controls were assessed by Mini-plus, Young mania and Hamilton depression rating scales. NGF levels were detected by ELISA. Results. Plasma NGF concentrations were decreased in BD patients when compared to that seen with controls. BD individuals in mania had lower NGF levels than euthymic patients or controls. NGF levels were negatively correlated with the severity of mania. Conclusions. This is the first study to evaluate NGF levels in BD patients, providing further support to the hypothesis of impaired neuro-plasticity in BD. These data also suggest that NGF measurement could be used for the biological marker for manic state.
C1 [Palotas, Andras] Asklepios Med Private Practice & Res Ctr, H-6722 Szeged, Hungary.
   [Barbosa, Izabela Guimaraes; Huguet, Rodrigo Barreto; Reis, Helton Jose; Teixeira, Antonio Lucio] Univ Fed Minas Gerais, Programa Neurociencias, Belo Horizonte, MG, Brazil.
   [Barbosa, Izabela Guimaraes; Huguet, Rodrigo Barreto] HGIP, Serv Psiquiatria, Inst Previdencia Servidores Minas Gerais IPSEMG, Belo Horizonte, MG, Brazil.
   [Barbosa, Izabela Guimaraes; Teixeira, Antonio Lucio] Univ Fed Minas Gerais ICB UFMG, Lab Immunofarmacol, Dept Bioquim & Imunol, Inst Ciencias Biol, Belo Horizonte, MG, Brazil.
   [Neves, Fernando Silva] Univ Fed Minas Gerais, Dept Saude Mental, Fac Med, Belo Horizonte, MG, Brazil.
   [Reis, Helton Jose] Univ Fed Minas Gerais ICB UFMG, Lab Neurofarmacol, Dept Farmacol, Inst Ciencias Biol, Belo Horizonte, MG, Brazil.
   [Bauer, Moises Evandro] Pontificia Univ Catolica Rio Grande Sul PUCRS, Lab Imunol Mol & Celular, Inst Pesquisas Biomed, Porto Alegre, RS, Brazil.
   [Janka, Zoltan] Univ Szeged, Dept Psychiat, Albert Szent Gyorgyi Clin Ctr, Fac Med, Szeged, Hungary.
   [Teixeira, Antonio Lucio] Univ Fed Minas Gerais, Dept Clin Med, Fac Med, Belo Horizonte, MG, Brazil.
C3 Universidade Federal de Minas Gerais; Universidade Federal de Minas
   Gerais; Universidade Federal de Minas Gerais; Universidade Federal de
   Minas Gerais; Pontificia Universidade Catolica Do Rio Grande Do Sul;
   Szeged University; Universidade Federal de Minas Gerais
RP Palotás, A (corresponding author), Asklepios Med Private Practice & Res Ctr, Kossuth Lajos Sgt 23, H-6722 Szeged, Hungary.
EM palotas@asklepios-med.eu
RI Teixeira, Antonio/N-3315-2014; Reis, Helton/HTQ-8232-2023; Bauer,
   Moises/J-9195-2015
OI Teixeira, Antonio Lucio/0000-0002-9621-5422; Reis, Helton
   J./0000-0002-4055-701X; Bauer, Moises/0000-0003-2957-1352
FU Rede Instituto Brasileiro de Neurociencia (Rede IBNet/MCT/Finep,
   Brazil); Conselho Nacional de Desenvolvimento Cientifico e Tecnologico
   (CNPq, Brazil); Fundacao de Amparo a Pesquisa do Estado de Minas Gerais
   (Fapemig, Brazil); Asklepios-Med (Hungary)
FX This work was funded by grants from Rede Instituto Brasileiro de
   Neurociencia (Rede IBNet/MCT/Finep, Brazil), Conselho Nacional de
   Desenvolvimento Cientifico e Tecnologico (CNPq, Brazil), Fundacao de
   Amparo a Pesquisa do Estado de Minas Gerais (Fapemig, Brazil), and by
   Asklepios-Med (Hungary).
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NR 30
TC 51
Z9 52
U1 0
U2 8
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1562-2975
EI 1814-1412
J9 WORLD J BIOL PSYCHIA
JI World J. Biol. Psychiatry
PD APR
PY 2011
VL 12
IS 3
BP 228
EP 232
DI 10.3109/15622975.2010.518629
PG 5
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychiatry
GA 749CH
UT WOS:000289439200007
PM 20923384
DA 2025-06-11
ER

PT J
AU Katsiki, N
   Hatzitolios, AI
   Mikhailidis, DP
AF Katsiki, Niki
   Hatzitolios, Apostolos I.
   Mikhailidis, Dimitri P.
TI Naltrexone sustained-release (SR) plus bupropion SR combination therapy
   for the treatment of obesity: 'A new kid on the block'?
SO ANNALS OF MEDICINE
LA English
DT Review
DE Bupropion; combination treatment; naltrexone; obesity; weight reduction
ID METABOLIC SYNDROME; CLINICAL-TRIAL; BLOOD-PRESSURE; DOUBLE-BLIND;
   WEIGHT-LOSS; SIBUTRAMINE; ORLISTAT; MANAGEMENT; CONSEQUENCES;
   AUGMENTATION
AB The prevalence of obesity is growing rapidly worldwide, and therefore there is a need for effective treatment strategies. The rationale of combination therapy in treating chronic diseases, such as obesity, is the potential additive or synergistic effects. This review considers the results of phase III clinical trials with naltrexone sustained-release (SR) ++ bupropion SR combination therapy in obese patients with or without type 2 diabetes mellitus. We also discuss the potential therapeutic applications of this weight-reducing treatment option. Recent clinical trials have shown that the administration of naltrexone SR ++ bupropion SR resulted in effective weight loss. Furthermore, this treatment was associated with improvement in cardiometabolic variables. Depression and suicidal ideation were more frequently reported in the placebo compared with the combination groups. However, significantly more patients on naltrexone SR ++ bupropion SR experienced adverse events, mainly nausea, and discontinued treatment compared with placebo. Increases in blood pressure and pulse rate were observed only in the combination groups. Further investigation is needed to clarify the clinical significance of this weight-reducing therapeutic option.
C1 [Katsiki, Niki; Mikhailidis, Dimitri P.] UCL, Sch Med, Royal Free Hosp Campus, Dept Clin Biochem Vasc Dis Prevent Clin, London NW3 2QG, England.
   [Katsiki, Niki; Hatzitolios, Apostolos I.] Aristotle Univ Thessaloniki, AHEPA Univ Hosp, Propedeut Dept Internal Med 1, GR-54006 Thessaloniki, Greece.
C3 University of London; University College London; UCL Medical School;
   Royal Free London NHS Foundation Trust; Aristotle University of
   Thessaloniki; Ahepa University Hospital
RP Mikhailidis, DP (corresponding author), UCL, Sch Med, Royal Free Hosp Campus, Dept Clin Biochem Vasc Dis Prevent Clin, Pond St, London NW3 2QG, England.
EM mikhailidis@aol.com
RI Mikhailidis, Dimitri/A-1869-2013; KATSIKI, NIKI/ADE-7999-2022
OI KATSIKI, NIKI/0000-0003-0894-2644; Hatzitolios,
   Apostolos/0000-0002-2323-8594
FU MSD; AstraZeneca; Genzyme; Pfizer; Alapis; Eli Lilly; Bayer; Hellenic
   Atherosclerosis Society
FX This study was conducted independently; no company or institution
   supported it financially. Some of the authors have given talks, attended
   conferences and participated in trials and advisory boards sponsored by
   MSD, AstraZeneca, Genzyme, Pfizer, Alapis, Eli Lilly, and Bayer.Dr N.
   Katsiki MD, FRSPH, is supported by a grant from the Hellenic
   Atherosclerosis Society.
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NR 55
TC 23
Z9 28
U1 0
U2 11
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0785-3890
EI 1365-2060
J9 ANN MED
JI Ann. Med.
PD JUN
PY 2011
VL 43
IS 4
BP 249
EP 258
DI 10.3109/07853890.2010.541490
PG 10
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 768LI
UT WOS:000290935700001
PM 21254901
DA 2025-06-11
ER

PT J
AU Brown, HE
   Ryde, GC
   Gilson, ND
   Burton, NW
   Brown, WJ
AF Brown, Helen Elizabeth
   Ryde, Gemma C.
   Gilson, Nicholas D.
   Burton, Nicola W.
   Brown, Wendy J.
TI Objectively Measured Sedentary Behavior and Physical Activity in Office
   Employees Relationships With Presenteeism
SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
LA English
DT Article
ID TYPE-2 DIABETES-MELLITUS; QUALITY-OF-LIFE; METABOLIC SYNDROME;
   HEALTH-BENEFITS; SITTING TIME; RISK; ASSOCIATIONS; WORK; INTERVENTION;
   DEPRESSION
AB Objective: Employee presenteeism is the extent to which health conditions adversely affect at-work productivity. Given the links between health and activity, this study examined associations between objectively measured physical activity, sedentary behavior, and presenteeism. Methods: Participants were 108 office employees (70% women, mean age 40.7 +/- 11.2 years). Activity was measured using ActiGraph GT3X+ accelerometers to determine sedentary (<= 150 counts) and light (151 to 1689 counts) activity; presenteeism with the Work Limitations Questionnaire. Results: Fifty-seven percent of time was spent in sedentary behavior and 38% in light activity. The median Work Limitations Questionnaire Index was 4.38; 6% of participants reported at least moderate impairment. Significant associations were reported for time spent in sedentary behavior before/after work (odds ratio [OR] = 2.58; 95% CI: 1.08 to 6.20) and in light activity, overall (OR = 0.43; 95% CI: 0.19 to 0.97) and duringworkday lunch hours (OR = 0.34; 95% CI: 0.15 to 0.77), and presenteeism. Conclusions: Future studies should seek greater variation in employee levels of activity and presenteeism to confirm these relationships.
C1 [Brown, Helen Elizabeth; Ryde, Gemma C.; Gilson, Nicholas D.; Burton, Nicola W.; Brown, Wendy J.] Univ Queensland, Sch Human Movement Studies, Brisbane, Qld 4072, Australia.
C3 University of Queensland
RP Brown, HE (corresponding author), Univ Queensland, Sch Human Movement Studies, St Lucia Campus, Brisbane, Qld 4072, Australia.
EM heb56@medschl.cam.ac.uk
RI Gilson, Nicholas/D-6056-2012; Brown, Helen/E-6594-2012; Brown,
   Wendy/A-1553-2016; Burton, Nicola/G-3313-2010; Brown, Wendy
   J/G-2201-2010
OI Gilson, Nicholas/0000-0002-5744-3609; Burton,
   Nicola/0000-0002-3221-2265; Ryde, Gemma/0000-0001-9117-0803; Brown,
   Wendy J/0000-0001-9093-4509
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NR 62
TC 53
Z9 62
U1 1
U2 41
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1076-2752
EI 1536-5948
J9 J OCCUP ENVIRON MED
JI J. Occup. Environ. Med.
PD AUG
PY 2013
VL 55
IS 8
BP 945
EP 953
DI 10.1097/JOM.0b013e31829178bf
PG 9
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA 300EX
UT WOS:000330448300015
PM 23887700
DA 2025-06-11
ER

PT J
AU Spangenberg, H
   Ramklint, M
   Cunningham, JL
   Ramirez, A
AF Spangenberg, Hanna
   Ramklint, Mia
   Cunningham, Janet L.
   Ramirez, Adriana
TI Correlations between personality traits, personality disorders, and
   immunometabolic markers
SO SCIENTIFIC REPORTS
LA English
DT Article
ID SWEDISH UNIVERSITIES SCALES; INFLAMMATORY MARKERS; NEUROTROPHIC FACTOR;
   METABOLIC SYNDROME; MAJOR DEPRESSION; 5-FACTOR MODEL; LEPTIN LEVELS;
   PREVALENCE; METAANALYSIS; CHEMOKINES
AB Evidence links immune system alterations to major psychiatric disorders. The few previous studies on personality traits or personality disorders (PDs) indicate that immunometabolic dysregulation may be prevalent in this population. This study aimed to investigate relationships between personality traits, PDs, and immunometabolic markers in peripheral blood. We hypothesized that neuroticism would be correlated with elevated leptin. Participants were recruited as young adults seeking care for general psychiatric disorders. They responded to a personality inventory and were assessed for PDs, and reevaluated again at a 12 years follow-up. Blood samples were collected at the follow-up and analyzed for 29 immunometabolic markers. A positive correlation was found between the personality trait neuroticism and leptin (rho = 0.31, p = 0.02). An exploratory analysis also revealed a positive correlation between brain-derived neurotrophic factor (rho = 0.36, p < 0.01) and neuroticism. These findings remained after adjusting for other variables in general linear models. There were no relationships between PDs and any immunometabolic markers. Results both confirm previous findings of correlations between the immunometabolic system and personality traits and suggest directions for future research.
C1 [Spangenberg, Hanna; Ramklint, Mia; Ramirez, Adriana] Uppsala Univ, Dept Med Sci Child & Adolescent Psychiat, Uppsala, Sweden.
   [Cunningham, Janet L.] Uppsala Univ, Dept Med Sci, Psychiat, Uppsala, Sweden.
C3 Uppsala University; Uppsala University
RP Spangenberg, H (corresponding author), Uppsala Univ, Dept Med Sci Child & Adolescent Psychiat, Uppsala, Sweden.
EM hanna.spangenberg@neuro.uu.se
RI Cunningham, Janet/C-4719-2013
FU Mrta and Nicke Nasvell Foundation
FX The authors wish to thank Mr. Hans Arinell for statistical support and
   associate Professor Annica J Rasmussen for assistance in sample and data
   management for biomarker analyses. The authors also wish to thank
   Uppsala Biobank for collaboration in sample management, Affinity
   Proteomics Unit, SciLife labs, Uppsala University for biomarker
   analyses, and the nursing staff at the Unit for Brain Stimulation at
   Uppsala University Hospital for assistance in blood sampling.
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NR 57
TC 0
Z9 0
U1 2
U2 3
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD MAY 21
PY 2024
VL 14
IS 1
AR 11635
DI 10.1038/s41598-024-62214-9
PG 9
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA RQ1B8
UT WOS:001229023500112
PM 38773198
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Hu, SH
   Li, A
   Huang, TT
   Lai, JB
   Li, JJ
   Sublette, ME
   Lu, HF
   Lu, QQ
   Du, YL
   Hu, ZY
   Ng, CE
   Zhang, H
   Lu, J
   Mou, TT
   Lu, SJ
   Wang, DD
   Duan, JF
   Hu, JB
   Huang, ML
   Wei, N
   Zhou, WH
   Ruan, LM
   Li, M
   Xu, Y
AF Hu, Shaohua
   Li, Ang
   Huang, Tingting
   Lai, Jianbo
   Li, Jingjing
   Sublette, M. Elizabeth
   Lu, Haifeng
   Lu, Qiaoqiao
   Du, Yanli
   Hu, Zhiying
   Ng, Chee H.
   Zhang, Hua
   Lu, Jing
   Mou, Tingting
   Lu, Shaojia
   Wang, Dandan
   Duan, Jinfeng
   Hu, Jianbo
   Huang, Manli
   Wei, Ning
   Zhou, Weihua
   Ruan, Lemin
   Li, Ming D.
   Xu, Yi
TI Gut Microbiota Changes in Patients with Bipolar Depression
SO ADVANCED SCIENCE
LA English
DT Article
DE 16S rRNA gene sequence; biomarkers; bipolar disorder; gut microbiota;
   quetiapine
ID FECAL MICROBIOTA; METABOLIC SYNDROME; RISK-FACTORS; DISORDER; BUTYRATE;
   COMMUNITIES; DIVERSITY; DYSBIOSIS; MARKER; HEALTH
AB This study aims to characterize the gut microbiota in depressed patients with bipolar disorder (BD) compared with healthy controls (HCs), to examine the effects of quetiapine treatment on the microbiota, and to explore the potential of microbiota as a biomarker for BD diagnosis and treatment outcome. Analysis of 16S-ribosomal RNA gene sequences reveals that gut microbial composition and diversity are significantly different between BD patients and HCs. Phylum Bacteroidetes and Firmicutes are the predominant bacterial communities in BD patients and HCs, respectively. Lower levels of butyrate-producing bacteria are observed in untreated patients. Microbial composition changes following quetiapine treatment in BD patients. Notably, 30 microbial markers are identified on a random forest model and achieve an area under the curve (AUC) of 0.81 between untreated patients and HCs. Ten microbial markers are identified with the AUC of 0.93 between responder and nonresponder patients. This study characterizes the gut microbiota in BD and is the first to evaluate microbial changes following quetiapine monotherapy. Gut microbiota-based biomarkers may be helpful in BD diagnosis and predicting treatment outcome, which need further validations.
C1 [Hu, Shaohua; Lai, Jianbo; Lu, Jing; Mou, Tingting; Lu, Shaojia; Wang, Dandan; Duan, Jinfeng; Hu, Jianbo; Huang, Manli; Wei, Ning; Zhou, Weihua; Xu, Yi] Zhejiang Univ, Sch Med, Affiliated Hosp 1, Dept Psychiat, Hangzhou 310003, Zhejiang, Peoples R China.
   [Hu, Shaohua; Lai, Jianbo; Lu, Jing; Mou, Tingting; Lu, Shaojia; Wang, Dandan; Duan, Jinfeng; Hu, Jianbo; Huang, Manli; Wei, Ning; Zhou, Weihua; Xu, Yi] Key Lab Mental Disorders Management Zhejiang Prov, 79 Qingchun Rd, Hangzhou 310003, Zhejiang, Peoples R China.
   [Hu, Shaohua; Lai, Jianbo; Lu, Jing; Mou, Tingting; Lu, Shaojia; Wang, Dandan; Duan, Jinfeng; Hu, Jianbo; Huang, Manli; Wei, Ning; Zhou, Weihua; Xu, Yi] Zhejiang Univ, Brain Res Inst, Hangzhou 310003, Zhejiang, Peoples R China.
   [Li, Ang] Zhengzhou Univ, Affiliated Hosp 1, Henan Gene Hosp, Zhengzhou 450052, Henan, Peoples R China.
   [Huang, Tingting; Lu, Qiaoqiao; Du, Yanli] Zhejiang Univ, Sch Med, Hangzhou 310058, Zhejiang, Peoples R China.
   [Li, Jingjing; Lu, Haifeng; Zhang, Hua; Li, Ming D.] Zhejiang Univ, Collaborat Innovat Ctr Diag & Treatment Infect Di, State Key Lab Diag & Treatment Infect Dis, Affiliated Hosp 1,Sch Med, Hangzhou 310003, Zhejiang, Peoples R China.
   [Li, Jingjing; Li, Ming D.] Zhejiang Univ, Res Ctr Air Pollut & Hlth, Hangzhou 310003, Zhejiang, Peoples R China.
   [Sublette, M. Elizabeth] Columbia Univ, Dept Psychiat, New York, NY 10032 USA.
   [Hu, Zhiying] Hangzhou Red Cross Hosp, Dept Obstet & Gynecol, Hangzhou 310003, Zhejiang, Peoples R China.
   [Ng, Chee H.] Univ Melbourne, Dept Psychiat, Melbourne Clin, Melbourne, Vic 3052, Australia.
   [Ruan, Lemin] Ningbo First Hosp, Dept Mental Hlth, Ningbo 315010, Zhejiang, Peoples R China.
C3 Zhejiang University; Zhejiang University; Zhengzhou University; Zhejiang
   University; Collaborative Innovation Center for Diagnosis & Treatment of
   Infectious Diseases; Zhejiang University; Zhejiang University; Columbia
   University; University of Melbourne; Ningbo University
RP Xu, Y (corresponding author), Zhejiang Univ, Sch Med, Affiliated Hosp 1, Dept Psychiat, Hangzhou 310003, Zhejiang, Peoples R China.; Xu, Y (corresponding author), Key Lab Mental Disorders Management Zhejiang Prov, 79 Qingchun Rd, Hangzhou 310003, Zhejiang, Peoples R China.; Xu, Y (corresponding author), Zhejiang Univ, Brain Res Inst, Hangzhou 310003, Zhejiang, Peoples R China.; Li, M (corresponding author), Zhejiang Univ, Collaborat Innovat Ctr Diag & Treatment Infect Di, State Key Lab Diag & Treatment Infect Dis, Affiliated Hosp 1,Sch Med, Hangzhou 310003, Zhejiang, Peoples R China.; Li, M (corresponding author), Zhejiang Univ, Res Ctr Air Pollut & Hlth, Hangzhou 310003, Zhejiang, Peoples R China.
EM ml2km@zju.edu.cn; xuyizju@zju.edu.cn
RI Hu, Shaohua/I-3336-2019; Lu, Qiaoqiao/GPO-0469-2022; Wang,
   Dandan/HLP-3441-2023; Huang, Tingting/L-4739-2019; Sublette,
   M/O-5621-2019; Lai, Jianbo/AAB-9530-2020; Li, Jing/GYU-5036-2022; meng,
   yan/GSE-2653-2022; Lu, Jing/KTH-7318-2024; Lu, Haifeng/ABG-5478-2021
OI Hu, Shaohua/0000-0003-0570-670X; Ng, Chee/0000-0002-3811-2732; Lai,
   Jianbo/0000-0002-8137-7701
FU National Key Research and Development Program of China [2016YFC1307104];
   Key Research Project of Zhejiang Province [2015C03040]; China Precision
   Medicine Initiative [2016YFC0906300]; National Natural Science
   Foundation of China [81371493]
FX S.-H.H. and A.L. contributed equally to this work. This study was funded
   in part by grants from the National Key Research and Development Program
   of China (No. 2016YFC1307104 to S.H.H.), the Key Research Project of
   Zhejiang Province (No. 2015C03040 to Y.X.), the China Precision Medicine
   Initiative (No. 2016YFC0906300 to M.D.L.), and the National Natural
   Science Foundation of China (No. 81371493 to S.H.).
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NR 66
TC 125
Z9 138
U1 6
U2 61
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
EI 2198-3844
J9 ADV SCI
JI Adv. Sci.
PD JUL 17
PY 2019
VL 6
IS 14
AR 1900752
DI 10.1002/advs.201900752
PG 11
WC Chemistry, Multidisciplinary; Nanoscience & Nanotechnology; Materials
   Science, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Science & Technology - Other Topics; Materials Science
GA IM0WY
UT WOS:000477711600014
PM 31380217
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Vancampfort, D
   Sienaert, P
   Wyckaert, S
   De Hert, M
   Stubbs, B
   Richards, J
   Mugisha, J
   Probst, M
AF Vancampfort, Davy
   Sienaert, Pascal
   Wyckaert, Sabine
   De Hert, Marc
   Stubbs, Brendon
   Richards, Justin
   Mugisha, James
   Probst, Michel
TI The Functional Exercise Capacity Is Associated With Global Functioning
   in People With Bipolar Disorder
SO JOURNAL OF NERVOUS AND MENTAL DISEASE
LA English
DT Article
DE Fitness; physical activity; bipolar disorder; depression
ID PHYSICAL-ACTIVITY QUESTIONNAIRE; METABOLIC SYNDROME; WALK TEST;
   PREDICTORS; VALIDITY; FITNESS; SCHIZOPHRENIA; METAANALYSIS; RELIABILITY;
   OUTPATIENTS
AB The aim of the current study was to determine whether the Global Assessment of Functioning (GAF) score is associated with the functional exercise capacity among in- and outpatients with bipolar disorder. Sixty-five (36f) persons with bipolar disorder performed a 6-minute walk test (6MWT) and were assessed with the GAF, Quick Inventory of Depressive Symptomatology Self Report (QIDS), and the International Physical Activity Questionnaire (IPAQ). The mean GAF-score was 55.0 +/- 15.0, whereas the mean distance achieved on the 6MWT was 615.6 +/- 118.6 m. There was a positive association between the GAF score and 6MWT score (r = 0.60, p < 0.001). A backward regression analysis demonstrated that an inpatient status, illness duration (16.1 +/- 10.7 years), and the QIDS score (7.7 +/- 5.7) explained 72.4% of the GAF-score variance. The GAF, QIDS score, and age explained 74.1% of the 6MWT-score variance. Our results indicate that a bidirectional relationship is evident between the exercise capacity and global functioning among people with bipolar disorder.
C1 [Vancampfort, Davy; Probst, Michel] KU Leuven Univ Leuven, Dept Rehabil Sci, Leuven, Belgium.
   [Vancampfort, Davy; Sienaert, Pascal; Wyckaert, Sabine; De Hert, Marc] KU Leuven Univ Leuven, KU Leuven Univ Psychiat Ctr, Kortenberg, Belgium.
   [Stubbs, Brendon] South London & Maudsley NHS Fdn Trust, Physiotherapy Dept, London, England.
   [Stubbs, Brendon] Kings Coll London, Inst Psychiat Psychol & Neurosci, Hlth Serv & Populat Res Dept, London, England.
   [Richards, Justin] Univ Sydney, Sch Publ Hlth, Sydney, NSW, Australia.
   [Richards, Justin] Univ Sydney, Charles Perkins Ctr, Sydney, NSW, Australia.
   [Mugisha, James] Butabika Natl Referral & Mental Hlth Hosp, Kampala, Uganda.
C3 KU Leuven; KU Leuven; South London & Maudsley NHS Trust; University of
   London; King's College London; University of Sydney; University of
   Sydney
RP Vancampfort, D (corresponding author), Leuvensesteenweg 517, B-3070 Kortenberg, Belgium.
EM Davy.Vancampfort@uc-kortenberg.be
RI sienaert, pascal/HTP-4217-2023; Stubbs, Brendon/X-1904-2018; Probst,
   Michel/ABE-6137-2020; De Hert, Marc/AAH-6090-2021; Vancampfort,
   Davy/AAD-1987-2019; Stubbs, Brendon/C-5696-2015
OI Stubbs, Brendon/0000-0001-7387-3791; De Hert, Marc/0000-0003-4255-5920;
   Sienaert, Pascal/0000-0002-0650-415X; Richards,
   Justin/0000-0003-4584-8614; Mugisha, James/0000-0003-2084-8693
FU Research Foundation-Flanders (FWO-Vlaanderen)
FX D.V. is funded by the Research Foundation-Flanders (FWO-Vlaanderen).
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NR 38
TC 7
Z9 7
U1 1
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0022-3018
EI 1539-736X
J9 J NERV MENT DIS
JI J. Nerv. Ment. Dis.
PD SEP
PY 2016
VL 204
IS 9
BP 673
EP 677
DI 10.1097/NMD.0000000000000580
PG 5
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA DX2XX
UT WOS:000384238100006
PM 27570898
DA 2025-06-11
ER

PT J
AU Janthakhin, Y
   Kingtong, S
   Juntapremjit, S
AF Janthakhin, Yoottana
   Kingtong, Sutin
   Juntapremjit, Sirikran
TI Inhibition of glucocorticoid synthesis alleviates cognitive impairment
   in high-fat diet-induced obese mice
SO COMPREHENSIVE PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE High -fat diet; Obesity; Memory impairments; Glucocorticoid; Synaptic
   plasticity
ID NEUROTROPHIC FACTOR; ANTIINFLAMMATORY CYTOKINES; CEREBROSPINAL-FLUID;
   MOOD DISORDERS; PLASMA-LEVELS; BDNF LEVELS; BETA LEVELS; DEPRESSION;
   BIOMARKERS; SERUM
AB In addition to cardiovascular diseases, metabolic syndrome and type 2 diabetes mellitus, obesity is associated with cognitive deficits. In rodents, it has been shown that long-term high-fat diet (HFD) consumption leads to the alteration of hypothalamic-pituitary-adrenal (HPA) axis resulting in increased corticosterone release. However, mechanisms underpinning cognitive impairments induced by long-term HFD intake are unclear. Herein we evaluated the effects of systemic administration of glucocorticoid synthesis inhibitor metyrapone on cognitive performance assessed by novel object recognition test and plasma corticosterone levels evaluated by enzyme -linked immunosorbent assay in HFD-induced obese mice. We found that metyrapone treatment alleviated recognition memory impairments in HFD-induced obese mice. Furthermore, glucocorticoid synthesis inhibitor also lowered plasma corticosterone levels in HFD-induced obese mice. Our findings indicate that hyperactivation of HPA axis resulting in elevated circulating glucocorticoid levels leads to memory impairments in HFD-induced obese mice. We identify glucocorticoid system as a potential therapeutic target for treating cognitive deficits associated with obesity condition.
C1 [Janthakhin, Yoottana; Juntapremjit, Sirikran] Burapha Univ, Coll Res Methodol & Cognit Sci, Cognit Sci & Innovat Res Unit CSIRU, Chon Buri 20131, Thailand.
   [Kingtong, Sutin] Burapha Univ, Fac Sci, Dept Biol, Chon Buri 20131, Thailand.
   [Janthakhin, Yoottana] Burapha Univ, Coll Res Methodol & Cognit Sci, 169 Long had Bangsaen Rd, Chon Buri 20131, Thailand.
C3 Burapha University; Burapha University; Burapha University
RP Janthakhin, Y (corresponding author), Burapha Univ, Coll Res Methodol & Cognit Sci, 169 Long had Bangsaen Rd, Chon Buri 20131, Thailand.
EM yoottana.ja@buu.ac.th
RI janthakhin, yoottana/HGE-4499-2022; Kingtong, Sutin/AAU-9453-2021
OI janthakhin, yoottana/0000-0002-5675-3453; Kingtong,
   Sutin/0000-0003-1464-5718
FU College of Research Methodology and Cognitive Science, Burapha
   University, Chonburi, Thailand
FX This work was supported by a research grant from the College of Research
   Methodology and Cognitive Science, Burapha University, Chonburi,
   Thailand.
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NR 35
TC 3
Z9 3
U1 0
U2 4
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2666-4976
J9 COMPR PSYCHONEUROEND
JI Compr. Psychoneuroendocrinol.
PD MAY
PY 2022
VL 10
AR 100130
DI 10.1016/j.cpnec.2022.100130
PG 4
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA Y3OM9
UT WOS:001104395700002
PM 35755209
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Barbosa, IG
   Rocha, NP
   de Miranda, AS
   Magalhaes, PVD
   Huguet, RB
   de Souza, LP
   Kapczinski, F
   Teixeira, AL
AF Barbosa, Izabela Guimaraes
   Rocha, Natalia Pessoa
   de Miranda, Aline Silva
   da Silva Magalhaes, Pedro Vieira
   Huguet, Rodrigo Barreto
   de Souza, Lirlandia Pires
   Kapczinski, Flavio
   Teixeira, Antonio Lucio
TI Increased levels of adipokines in bipolar disorder
SO JOURNAL OF PSYCHIATRIC RESEARCH
LA English
DT Article
DE Bipolar disorder; Obesity; Adipokines; Inflammation; Biomarkers
ID SERUM LEPTIN LEVELS; METABOLIC SYNDROME; CHOLESTEROL LEVELS;
   PLASMA-LEVELS; ADIPONECTIN; OVERWEIGHT; INFLAMMATION; OBESITY; WEIGHT;
   COMORBIDITY
AB Bipolar disorder (BD) is associated with considerable higher chronic medical comorbidities, overweight and obesity. Adipokines are adipocyte-derived secretory factors which have functions in immune response and seem to be associated with both BD and overweight. The aim of this study was to evaluate the plasma levels of adipokines (adiponectin, resistin and leptin) and TNF-alpha and its receptors (sTNFR1 and sTNFR2) in BD overweight patients in comparison with overweight controls. Thirty euthymic BD type-I patients and thirty controls matched by age, gender and body-mass index (BMI) were assessed by Mini-International Neuropsychiatric Interview, Young Mania and Hamilton Depression rating scales (YMRS and HDRS, respectively). Plasma levels of adiponectin, resistin, leptin, TNF-alpha and its soluble receptors were measured by ELISA. BD patients presented increased plasma levels of adiponectin (p < 0.001), leptin (p < 0.001) and sTNFR1 (p = 0.01). Plasma levels of adipokines were not correlated neither with clinical parameters nor TNF-alpha, sTNFR1 and sTNFR2 plasma levels. This study provides further support to the hypothesis of the immune/inflammatory imbalance in BD. (C) 2011 Elsevier Ltd. All rights reserved.
C1 [Teixeira, Antonio Lucio] Univ Fed Minas Gerais, Inst Ciencias Biol, Lab Imunofarmacol, Dept Bioquim & Imunol, BR-31270901 Belo Horizonte, MG, Brazil.
   [Barbosa, Izabela Guimaraes; Rocha, Natalia Pessoa; Teixeira, Antonio Lucio] Univ Fed Minas Gerais, Programa Posgrad & Neurociencias, BR-31270901 Belo Horizonte, MG, Brazil.
   [da Silva Magalhaes, Pedro Vieira; Kapczinski, Flavio] Univ Fed Rio Grande do Sul, Mol Psychiat Lab, Porto Alegre, RS, Brazil.
   [da Silva Magalhaes, Pedro Vieira; Kapczinski, Flavio] Univ Fed Rio Grande do Sul, INCT Translat Med, Hosp Clin Porto Alegre HCPA, Porto Alegre, RS, Brazil.
C3 Universidade Federal de Minas Gerais; Universidade Federal de Minas
   Gerais; Universidade Federal do Rio Grande do Sul; Hospital de Clinicas
   de Porto Alegre; Universidade Federal do Rio Grande do Sul
RP Teixeira, AL (corresponding author), Univ Fed Minas Gerais, Inst Ciencias Biol, Lab Imunofarmacol, Dept Bioquim & Imunol, Av Antonio Carlos 6627, BR-31270901 Belo Horizonte, MG, Brazil.
EM altexr@gmail.com
RI Miranda, Aline/AFM-2106-2022; Teixeira, Antonio/N-3315-2014; Magalhaes,
   Pedro/A-8519-2008; Silva de Miranda, Aline/L-5507-2016; Rocha, Natalia
   Pessoa/S-4021-2018; Kapczinski, Flavio/D-3175-2013
OI Teixeira, Antonio Lucio/0000-0002-9621-5422; Magalhaes,
   Pedro/0000-0002-5644-6357; Silva de Miranda, Aline/0000-0003-2811-7924;
   Rocha, Natalia Pessoa/0000-0003-2616-8082; Kapczinski,
   Flavio/0000-0001-8738-856X
FU Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq,
   Brazil); Fundacao de Amparo a Pesquisa do Estado de Minas Gerais
   (Fapemig, Brazil); Coordenacao de Aperfeicoamento de Pessoal de Nivel
   Superior (CAPES, Brazil)
FX This work was funded by Conselho Nacional de Desenvolvimento Cientifico
   e Tecnologico (CNPq, Brazil) and Fundacao de Amparo a Pesquisa do Estado
   de Minas Gerais (Fapemig, Brazil). Dr. Barbosa is supported by a
   doctoral scholarship from Coordenacao de Aperfeicoamento de Pessoal de
   Nivel Superior (CAPES, Brazil).
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NR 45
TC 75
Z9 78
U1 0
U2 8
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-3956
EI 1879-1379
J9 J PSYCHIATR RES
JI J. Psychiatr. Res.
PD MAR
PY 2012
VL 46
IS 3
BP 389
EP 393
DI 10.1016/j.jpsychires.2011.11.010
PG 5
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 911YJ
UT WOS:000301760300017
PM 22137759
DA 2025-06-11
ER

PT J
AU Yi, JE
   Youn, HJ
AF Yi, Jeong-Eun
   Youn, Ho-Joong
TI Hemorheological abnormalities and their associations with coronary blood
   flow in patients with cardiac syndrome X: a comparison between males and
   females
SO PERFUSION-UK
LA English
DT Article
DE cardiac syndrome X; whole blood viscosity; coronary blood flow; tissue
   oxygen delivery index; gender difference
ID ARTERY-DISEASE; EDINBURGH ARTERY; VISCOSITY RATIO; ANGINA-PECTORIS;
   STABLE ANGINA; HEART-DISEASE; SHEAR-STRESS; ATHEROSCLEROSIS; HEMATOCRIT;
   RHEOLOGY
AB Aim: The role of elevated whole blood viscosity (WBV) in the pathogenesis of atherosclerosis is well known. We sought to investigate the gender differences in the association between WBV, coronary blood flow and tissue oxygen delivery index (TODI) in cardiac syndrome X (CSX).
   Methods: Forty-six CSX patients and 14 healthy volunteers were enrolled. The coronary flow parameters were obtained with transthoracic Doppler echocardiography and WBV was measured (at high-shear and low-shear rates of 300s(-1) and 5s(-1), respectively) using a scanning capillary tube viscometer. TODI was determined from the ratio of hematocrit to WBV measured at a low-shear rate of 5s(-1).
   Results: In male patients, the mean diastolic coronary flow velocity (CFV) and diastolic velocity time integral (VTI) were significantly decreased compared to control group (all p<0.05) and the WBV showed significant negative correlation with peak systolic CFV (r = -0.559 at 300s(-1), r = -0.438 at 5s(-1)), mean systolic CFV (r = -0.577 at 300s(-1), r = -0.488 at 5s(-1)), systolic VTI (r = -0.576 at 300s(-1), r = -0.530 at 5s(-1)) and diastolic VTI (r = -0.553 at 300s(-1), r = -0.551 at 5s(-1)) (all p<0.01). Meanwhile, although female patients showed no significant relationships between WBV and coronary flow parameters, TODI were significantly decreased compared to the control group (3.64 0.34 vs. 4.07 +/- 0.38%/centipoises (cP), respectively, p=0.008).
   Conclusion: Our study suggests that there are gender-related differences in the pathogenesis of microvascular angina and gender-specific approaches for CSX patients might be needed.
C1 [Yi, Jeong-Eun] Ewha Womans Univ, Sch Med, Mokdong Hosp, Dept Cardiol, Seoul, South Korea.
   [Youn, Ho-Joong] Catholic Univ Korea, Coll Med, Seoul St Marys Hosp, Dept Cardiol, Seoul, South Korea.
C3 Ewha Womans University; Catholic University of Korea; Seoul St. Mary's
   Hospital
RP Youn, HJ (corresponding author), Catholic Univ Korea, Seoul St Marys Hosp, Div Cardiol, Dept Internal Med,Coll Med, 505 Banpo Dong, Seoul 137701, South Korea.
EM younhj@catholic.ac.kr
FU Seoul St. Mary's Hospital, The Catholic University of Korea
FX The authors disclosed receipt of the following financial support for the
   research, authorship, and/or publication of this article: This study was
   supported by Research Fund of Seoul St. Mary's Hospital, The Catholic
   University of Korea.
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NR 37
TC 4
Z9 5
U1 0
U2 5
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0267-6591
EI 1477-111X
J9 PERFUSION-UK
JI Perfusion-UK
PD JAN
PY 2017
VL 32
IS 1
BP 57
EP 67
DI 10.1177/0267659116661052
PG 11
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA EH2BY
UT WOS:000391573600009
PM 27440799
DA 2025-06-11
ER

PT J
AU Dani, H
   Esdaille, A
   Weiss, JP
AF Dani, Hasan
   Esdaille, Ashanda
   Weiss, Jeffrey P.
TI Nocturia: aetiology and treatment in adults
SO NATURE REVIEWS UROLOGY
LA English
DT Review
ID URINARY-TRACT SYMPTOMS; BENIGN PROSTATIC HYPERPLASIA; ORALLY
   DISINTEGRATING TABLET; QUALITY-OF-LIFE; STANDARDIZATION SUB-COMMITTEE;
   CORONARY-HEART-DISEASE; ALL-CAUSE MORTALITY; SLOW-WAVE SLEEP; ADD-ON
   THERAPY; DOUBLE-BLIND
AB Nocturia is an extremely common condition that has major sequelae for affected patients. Through disruption of sleep, nocturia impairs quality of life and worsens health outcomes, and is associated with a variety of morbidities including diabetes, coronary artery disease, obstructive sleep apnoea, obesity, metabolic syndrome, and depression. Unsurprisingly, several studies have also linked nocturia with reduced survival. Nocturia is not simply a consequence of lower urinary tract disease; rather, it is a multifactorial disorder that is often a manifestation of an underlying renal or systemic disease. Through the use of the frequency volume chart, clinicians can accurately quantify nocturia and determine its aetiology. Evaluation of quality of life and sleep using simple measures is essential in order to assess the impact of nocturia on a patient. Numerous treatment options for nocturia exist, but most are associated with minor benefit or lack sufficient evidence supporting their use. By systematically analysing an individual's causes of nocturia, clinicians can design appropriate treatment strategies to most effectively treat this condition.
C1 [Dani, Hasan; Esdaille, Ashanda; Weiss, Jeffrey P.] SUNY Downstate Coll Med, Dept Urol, 450 Clarkson Ave, Brooklyn, NY 11226 USA.
C3 State University of New York (SUNY) System; SUNY Downstate Health
   Sciences University
RP Weiss, JP (corresponding author), SUNY Downstate Coll Med, Dept Urol, 450 Clarkson Ave, Brooklyn, NY 11226 USA.
EM urojock@aol.com
OI Esdaille, Ashanda/0000-0002-9073-6497
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NR 142
TC 48
Z9 48
U1 0
U2 13
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 1759-4812
EI 1759-4820
J9 NAT REV UROL
JI Nat. Rev. Urol.
PD OCT
PY 2016
VL 13
IS 10
BP 573
EP 583
DI 10.1038/nrurol.2016.134
PG 11
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Urology & Nephrology
GA DY9TH
UT WOS:000385477500016
PM 27455894
DA 2025-06-11
ER

PT J
AU Jefferis, BJ
   Sartini, C
   Lee, IM
   Choi, M
   Amuzu, A
   Gutierrez, C
   Casas, JP
   Ash, S
   Lennnon, LT
   Wannamethee, SG
   Whincup, PH
AF Jefferis, Barbara J.
   Sartini, Claudio
   Lee, I-Min
   Choi, Minkyoung
   Amuzu, Antoinette
   Gutierrez, Christina
   Casas, Juan Pablo
   Ash, Sarah
   Lennnon, Lucy T.
   Wannamethee, S. Goya
   Whincup, Peter H.
TI Adherence to physical activity guidelines in older adults, using
   objectively measured physical activity in a population-based study
SO BMC PUBLIC HEALTH
LA English
DT Article
DE Older adults; Physical activity; Accelerometer; Physical health;
   Depression; Self-efficacy
ID SEDENTARY BEHAVIOR; DISEASE; HEALTH; RELIABILITY; HEART
AB Background: Physical activity (PA) levels in older adults decline with age. The prevalence and correlates of adherence to current UK PA guidelines in older adults has not been studied using objectively measured PA, which can examine precisely whether PA is carried out in bouts of specified length and intensity.
   Methods: Free living men and women aged 70-93 years from 25 towns in the United Kingdom, participating in parallel on-going population based cohort studies were invited (by post) to wear a GT3x accelerometer over the hip for one week in 2010-12. Adherence to UK PA guidelines was defined as >= 150 minutes/week of moderate or vigorous PA (MVPA) in bouts of >= 10 minutes; the effect of different intensities and durations were examined.
   Results: 1593 men and 857 women participated (responses 51% and 29% respectively). 15% men and 10% women achieved >= 150 minutes/week of MVPA (defined as > 1040 cpm) in bouts lasting >= 10 minutes. With MVPA defined as > 1952 cpm, prevalences were 7% and 3% respectively. Those adhering to guidelines were younger, had fewer chronic health conditions, less depression, less severe mobility limitations, but higher exercise self-efficacy and exercise outcomes expectations. They rated their local environment more highly for social activities and leisure facilities, having somewhere nice to go for a walk and feeling safe after dark, They left the house on more days per week, were more likely to use active transport (cycle or walk) and to walk a dog regularly.
   Conclusions: Few older adults attain current PA guidelines. Health promotion to extend the duration of moderate-intensity activity episodes to 10 minutes or more could yield important health gains among older adults. However future studies will need to clarify whether attaining guideline amounts of PA in spells lasting 10 minutes or more is critical for reducing chronic disease risks as well as improving cardiometabolic risk factors.
C1 [Jefferis, Barbara J.; Sartini, Claudio; Ash, Sarah; Lennnon, Lucy T.; Wannamethee, S. Goya] UCL, UCL Dept Primary Care & Populat Hlth, London, England.
   [Jefferis, Barbara J.] UCL Phys Activ Res Grp, London, England.
   [Lee, I-Min] Harvard Univ, Brigham & Womens Hosp, Sch Med, Boston, MA 02115 USA.
   [Choi, Minkyoung; Amuzu, Antoinette; Gutierrez, Christina; Casas, Juan Pablo] London Sch Hyg & Trop Med, Dept Non Communicable Dis Epidemiol, London WC1, England.
   [Casas, Juan Pablo] UCL, Inst Cardiovasc Sci, London, England.
   [Whincup, Peter H.] St Georges Univ London, Div Community Hlth Sci, London, England.
C3 University of London; University College London; University of London;
   University College London; Harvard University; Harvard University
   Medical Affiliates; Brigham & Women's Hospital; Harvard Medical School;
   University of London; London School of Hygiene & Tropical Medicine;
   University of London; University College London; City St Georges,
   University of London; St Georges University London
RP Jefferis, BJ (corresponding author), UCL, UCL Dept Primary Care & Populat Hlth, London, England.
EM b.jefferis@ucl.ac.uk
RI Jefferis, Barbara/AAE-5186-2020; Sterling, Juan/KHY-6315-2024; Lee,
   I-Min/ABD-5409-2021; Lennon, Lucy/AFT-1973-2022; Jefferis,
   Barbara/C-1786-2008
OI Ash, Sarah/0000-0002-2185-2275; Lennon, Lucy/0000-0002-1738-1351;
   Sartini, Claudio/0000-0002-1470-3212; Whincup,
   Peter/0000-0002-5589-4107; Wannamethee, Sasiwarang/0000-0001-9484-9977;
   Jefferis, Barbara/0000-0002-0850-3177
FU National Institute for Health Research [PDF-2010-03-23]; British Heart
   Foundation [RG/08/013/25942, PG/09/022]; Department of Health Policy
   Research Programme (England) [0090049]; US National Institutes of Health
   [CA154647]; National Institutes of Health Research (NIHR)
   [PDF-2010-03-23] Funding Source: National Institutes of Health Research
   (NIHR)
FX This report is independent research arising from a Post-Doctoral
   Fellowship (to Barbara Jefferis) supported by the National Institute for
   Health Research (PDF-2010-03-23). The British Regional Heart Study is
   supported by a programme grant from the British Heart Foundation
   (RG/08/013/25942). The British Women's heart Health Study was supported
   by grants from the Department of Health Policy Research Programme
   (England) (0090049) and the British Heart Foundation (PG/09/022). I-Min
   Lee was supported in part by grant CA154647 from the US National
   Institutes of Health. The views expressed in this publication are those
   of the author(s) and not necessarily those of the NHS, the National
   Institute for Health Research or the Department of Health.
CR [Anonymous], PHYS ACTIVITY PROCES
   [Anonymous], 2008, Physical Activity Guidelines Advisory Committee Report, 2008
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NR 31
TC 193
Z9 216
U1 3
U2 101
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2458
J9 BMC PUBLIC HEALTH
JI BMC Public Health
PD APR 19
PY 2014
VL 14
AR 382
DI 10.1186/1471-2458-14-382
PG 9
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA AG6AC
UT WOS:000335499700001
PM 24745369
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU You, JS
   Xia, SJ
AF You, Jinshun
   Xia, Shujie
TI Association between the dietary inflammatory index and depressive
   symptoms in adults with metabolic syndrome: a cross-sectional study from
   the NHANES database
SO FRONTIERS IN NUTRITION
LA English
DT Article
DE diet; depression; inflammation; adult population; database
AB Objective The comorbidity of metabolic syndrome (MS) and depressive symptoms has emerged as a growing public health concern, contributing to a substantial global economic burden. The pathogenesis of this comorbidity is thought to be closely linked to inflammation. However, research examining the impact of the Dietary Inflammatory Index (DII) on depressive symptoms in adults with MS remains limited. This study aims to investigate the association between the DII and depressive symptoms in adults with MS, utilizing data from the National Health and Nutrition Examination Survey (NHANES).Methods This cross-sectional study included 7,553 participants aged 20 and older MS from six cycles of the NHANES (2007-2018). Depressive symptoms were assessed using the Patient Health Questionnaire scores, and dietary information was gathered to calculate the Dietary Inflammatory Index (DII). The association between DII scores and depressive symptoms in individuals with MS was evaluated through multivariable logistic regression analysis, adjusting for relevant covariates. Subgroup analyses and restricted cubic splines (RCS) were performed to explore this relationship further.Results Among the participants, 907 individuals (12.0%) were identified as having depressive symptoms. After adjusting for all covariates, a positive correlation was observed (OR = 1.09, 95% CI: 1.04-1.14). After adjusting for all covariates, a positive association was observed between DII scores and depressive symptoms (OR = 1.09, 95% CI: 1.04-1.14). Individuals in the highest tertile of DII scores had significantly higher odds of depressive symptoms compared to those in the lowest tertile (OR = 1.36, 95% CI: 1.13-1.65). Subgroup analyses revealed that men were more likely to experience depressive symptoms among adults with MS. The RCS model revealed a nonlinear positive association between DII scores and depressive symptoms in these participants.Conclusion Our study indicates that the DII is positively correlated with an increased likelihood of depressive symptoms among adults with MS in the United States. These findings align with existing research and necessitate further validation through prospective cohort studies.
C1 [You, Jinshun; Xia, Shujie] Fujian Univ Tradit Chinese Med, Fuzhou, Peoples R China.
   [You, Jinshun] Fujian Univ Tradit Chinese Med, Peoples Hosp 2, Fuzhou, Peoples R China.
C3 Fujian University of Traditional Chinese Medicine; Fujian University of
   Traditional Chinese Medicine
RP Xia, SJ (corresponding author), Fujian Univ Tradit Chinese Med, Fuzhou, Peoples R China.
EM xiashujie121@126.com
FU National Natural Science Foundation of China [82204977]; Fujian
   University of Traditional Chinese Medicine [XQC2023002]
FX The authors thank all NHANES participants for their altruistic
   contributions to our research. The authors also thank the National
   Natural Science Foundation of China and Fujian University of Traditional
   Chinese Medicine for their financial support for this study.
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NR 32
TC 0
Z9 0
U1 4
U2 4
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD JAN 27
PY 2025
VL 12
AR 1518551
DI 10.3389/fnut.2025.1518551
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA W0Z8B
UT WOS:001415968800001
PM 39931372
OA gold
DA 2025-06-11
ER

PT J
AU Rodrigues, TRC
   Breeman, LD
   Kinik, A
   Reijnders, T
   Dusseldorp, E
   Janssen, VR
   Kraaijenhagen, RA
   Atsma, DE
   Evers, AWM
   BENEFIT Consortium
AF Rodrigues, Talia R. Cohen
   Breeman, Linda D.
   Kinik, Asena
   Reijnders, Thomas
   Dusseldorp, Elise
   Janssen, Veronica R.
   Kraaijenhagen, Roderik A.
   Atsma, Douwe E.
   Evers, Andrea W. M.
   BENEFIT Consortium
TI Effectiveness of Human-Supported and Self-Help eHealth Lifestyle
   Interventions for Patients With Cardiometabolic Risk Factors: A
   Meta-Analysis
SO PSYCHOSOMATIC MEDICINE
LA English
DT Review
DE cardiovascular disease; chronic kidney disease; type 1 diabetes
   mellitus; type 2 diabetes mellitus; eHealth; lifestyle change; human
   support
ID INTERNET-BASED INTERVENTIONS; RANDOMIZED CONTROLLED-TRIAL; CARDIAC
   REHABILITATION; DISEASE; PREVENTION; DEPRESSION; GUIDELINES; BEHAVIOR;
   PROGRAM; HABITS
AB Objective: eHealth is a useful tool to deliver lifestyle interventions for patients with cardiometabolic diseases. However, there are inconsistent findings about whether these eHealth interventions should be supported by a human professional, or whether self-help interventions are equally effective. Methods: Databases were searched between January 1995 and October 2021 for randomized controlled trials on cardiometabolic diseases (cardiovascular disease, chronic kidney disease, type 1 and 2 diabetes mellitus) and eHealth lifestyle interventions. A multilevel meta-analysis was used to pool clinical and behavioral health outcomes. Moderator analyses assessed the effect of intervention type (self-help versus human-supported), dose of human support (minor versus major part of intervention), and delivery mode of human support (remote versus blended). One hundred seven articles fulfilled eligibility criteria and 102 unique (N = 20,781) studies were included. Results: The analysis showed a positive effect of eHealth lifestyle interventions on clinical and behavioral health outcomes (p < .001). However, these effects were not moderated by intervention type (p = .169), dose (p = .698), or delivery mode of human support (p = .557). Conclusions: This shows that self-help eHealth interventions are equally effective as human-supported ones in improving health outcomes among patients with cardiometabolic disease. Future studies could investigate whether higher-quality eHealth interventions compensate for a lack of human support.Meta-analysis registration: PROSPERO CRD42021269263.
C1 [Rodrigues, Talia R. Cohen; Breeman, Linda D.; Kinik, Asena; Reijnders, Thomas; Janssen, Veronica R.; Evers, Andrea W. M.] Leiden Univ, Inst Psychol, Hlth Med & Neuropsychol Unit, Leiden, Netherlands.
   [Dusseldorp, Elise] Leiden Univ, Inst Psychol, Methodol & Stat Grp, Leiden, Netherlands.
   [Janssen, Veronica R.; Atsma, Douwe E.] Leiden Univ Med Ctr, Dept Cardiol, Leiden, Netherlands.
   [Kraaijenhagen, Roderik A.] NDDO Inst Prevent & Early Diagnost NIPED, Amsterdam, Netherlands.
   [Kraaijenhagen, Roderik A.] Vital10, Amsterdam, Netherlands.
   [Evers, Andrea W. M.] Leiden Univ Med Ctr, Dept Psychiat, Leiden, Netherlands.
   [Evers, Andrea W. M.] Delft Univ Technol, Leiden Univ, Med Delta, Delft, Netherlands.
   [Evers, Andrea W. M.] Erasmus Univ, Rotterdam, Netherlands.
   [Rodrigues, Talia R. Cohen] Wassenaarseweg 52, NL-2333 AK Leiden, Netherlands.
C3 Leiden University; Leiden University - Excl LUMC; Leiden University -
   Excl LUMC; Leiden University; Leiden University; Leiden University
   Medical Center (LUMC); Leiden University; Leiden University Medical
   Center (LUMC); Delft University of Technology; Leiden University - Excl
   LUMC; Leiden University; Erasmus University Rotterdam - Excl Erasmus MC;
   Erasmus University Rotterdam
RP Rodrigues, TRC (corresponding author), Wassenaarseweg 52, NL-2333 AK Leiden, Netherlands.
EM t.r.cohen.rodrigues@fsw.leidenuniv.nl; breemanld@vuw.leidenuniv.nl;
   asenakinik@outlook.de; t.reijnders@fsw.leidenuniv.nl;
   elise.dusseldorp@fsw.leidenuniv.nl; vjanssen@fsw.leidenuniv.nl;
   r.kraaijenhagen@vital10.nl; d.e.atsma@lumc.nl;
   eversawm@vuw.leidenuniv.nl
RI Evers, Andrea/GWV-9705-2022; Breeman, Linda/M-8442-2018
OI Janssen, Veronica/0000-0003-4113-6716; Breeman,
   Linda/0000-0002-4441-2731; Dusseldorp, Elise/0000-0002-6305-4060
FU Authors' Contributions: Study design: T.R.C.R., L.D.B., T.R., V.R.J.,
   A.W.M.E.; data acquisition: T.R.C.R., A.K.; data analysis and
   interpretation: T.R.C.R., L.D.B., E.D.; drafting the manuscript:
   T.R.C.R., L.D.B., A.K., T.R.; manuscript revision: T.R.C.R.
FX We would like to thank Shyvana de Hoog and Emily White (master's degree
   in psychology students at Leiden University) for their assistance during
   the data acquisition phase.r Source of Funding and Conflicts of
   Interest: This work was supported by The Netherlands Cardiovascular
   Research Initiative: an initiative with support of the Dutch Heart
   Foundation, CVON2016-12 BENEFIT, ZonMw (The Netherlands Organization for
   Health Research and Development), and the members of the BENEFIT
   consortium. Moreover, the research was supported by an NWO Stevin
   Premium granted to A.W.M.E. The authors report no conflicts of
   interest.r Authors' Contributions: Study design: T.R.C.R., L.D.B., T.R.,
   V.R.J., A.W.M.E.; data acquisition: T.R.C.R., A.K.; data analysis and
   interpretation: T.R.C.R., L.D.B., E.D.; drafting the manuscript:
   T.R.C.R., L.D.B., A.K., T.R.; manuscript revision: T.R.C.R., L.D.B.,
   A.K., T.R., E.D., V.R.J., R.A.K., D.E.A., A.W.M.E. All authors gave
   final approval and agree to be accountable for all aspects of the work
   ensuring integrity and accuracy.
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NR 46
TC 2
Z9 2
U1 1
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0033-3174
EI 1534-7796
J9 PSYCHOSOM MED
JI Psychosom. Med.
PD NOV-DEC
PY 2023
VL 85
IS 9
BP 795
EP 804
DI 10.1097/PSY.0000000000001242
PG 10
WC Psychiatry; Psychology; Psychology, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry; Psychology
GA X6YB9
UT WOS:001099872500007
PM 37549197
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Stapel, B
   Jelinic, M
   Drummond, GR
   Hartung, D
   Kahl, KG
AF Stapel, Britta
   Jelinic, Maria
   Drummond, Grant R.
   Hartung, Dagmar
   Kahl, Kai G.
TI Adipose Tissue Compartments, Inflammation, and Cardiovascular Risk in
   the Context of Depression
SO FRONTIERS IN PSYCHIATRY
LA English
DT Review
DE adipose tissue; inflammation; major depressive disorder; cardiovascular
   disease; HPA axis; body composition
ID BODY-MASS INDEX; ADRENAL-GLAND VOLUME; C-REACTIVE PROTEIN; METABOLIC
   SYNDROME; VISCERAL FAT; ABDOMINAL OBESITY; MENTAL-ILLNESS; SCIENTIFIC
   STATEMENT; PRACTICE GUIDELINES; ALZHEIMER-DISEASE
AB The neurobiological and behavioral underpinnings linking mental disorders, in particular, major depressive disorder (MDD), with cardiovascular disorders are a matter of debate. Recent research focuses on visceral (intra-abdominal and epicardial) adipose tissue and inflammation and their impact on the development of cardiometabolic disorders. Intra-abdominal adipose tissue is defined as an endocrine active fat compartment surrounding inner organs and is associated with type 2 diabetes mellitus, a risk factor for the later development of cardiovascular disorders. Epicardial (pericardial) adipose tissue is a fat compartment surrounding the heart with close proximity to the arteries supporting the heart. Visceral adipose tissue (VAT) is an important source of inflammatory mediators that, in concert with other risk factors, plays a leading role in cardiovascular diseases. In conjunction with the behavioral (physical inactivity, sedentary lifestyle), psychological (adherence problems), and hormonal (dysfunction of the hypothalamus-pituitary-adrenal axis with subsequent hypercortisolism) alterations frequently accompanying MDD, an enhanced risk for cardiovascular disorders results.
C1 [Stapel, Britta; Kahl, Kai G.] Hannover Med Sch, Dept Psychiat Social Psychiat & Psychotherapy, Hannover, Germany.
   [Jelinic, Maria; Drummond, Grant R.] La Trobe Univ, Ctr Cardiovasc Biol & Dis Res, Dept Physiol Anat & Microbiol, Bundoora, VIC, Australia.
   [Hartung, Dagmar] Inst Diagnosticand Intervent Radiol, Hannover Med Sch, Hannover, Germany.
C3 Hannover Medical School; La Trobe University; Hannover Medical School
RP Kahl, KG (corresponding author), Hannover Med Sch, Dept Psychiat Social Psychiat & Psychotherapy, Hannover, Germany.
EM kahl.kai@mh-hannover.de
RI Drummond, Grant/A-7427-2008
OI Drummond, Grant/0000-0001-8556-9738; Jelinic, Maria/0000-0001-9773-4972
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NR 129
TC 12
Z9 12
U1 2
U2 6
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-0640
J9 FRONT PSYCHIATRY
JI Front. Psychiatry
PD APR 4
PY 2022
VL 13
AR 831358
DI 10.3389/fpsyt.2022.831358
PG 14
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 0X9DK
UT WOS:000789999600001
PM 35444568
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Kittel-Schneider, S
   Bury, D
   Leopold, K
   Haack, S
   Bauer, M
   Pfeiffer, S
   Sauer, C
   Pfennig, A
   Völzke, H
   Grabe, HJ
   Reif, A
AF Kittel-Schneider, Sarah
   Bury, Daniel
   Leopold, Karolina
   Haack, Sara
   Bauer, Michael
   Pfeiffer, Steffi
   Sauer, Cathrin
   Pfennig, Andrea
   Voelzke, Henry
   Grabe, Hans-Joergen
   Reif, Andreas
TI Prevalence of Prediabetes and Diabetes Mellitus Type II in Bipolar
   Disorder
SO FRONTIERS IN PSYCHIATRY
LA English
DT Article
DE bipolar disorder; diabetes mellitus; prediabetes; affective disorders;
   metabolic syndrome; glucose metabolism; obesity; body mass index
ID MAJOR DEPRESSIVE DISORDER; METABOLIC SYNDROME; MENTAL-ILLNESS;
   INSULIN-RESISTANCE; GLUCOSE REGULATION; ITALIAN PATIENTS; RISK;
   MORTALITY; OBESITY; HEALTH
AB Introduction
   Bipolar disorder (BD) is characterized by recurrent episodes of depression and mania and affects up to 2% of the population worldwide. Patients suffering from bipolar disorder have a reduced life expectancy of up to 10 years. The increased mortality might be due to a higher rate of somatic diseases, especially cardiovascular diseases. There is however also evidence for an increased rate of diabetes mellitus in BD, but the reported prevalence rates vary by large.
   Material and Methods
   85 bipolar disorder patients were recruited in the framework of the BiDi study (Prevalence and clinical features of patients with Bipolar Disorder at High Risk for Type 2 Diabetes (T2D), at prediabetic state and with manifest T2D) in Dresden and Wurzburg. T2D and prediabetes were diagnosed measuring HBA1c and an oral glucose tolerance test (oGTT), which at present is the gold standard in diagnosing T2D. The BD sample was compared to an age-, sex- and BMI-matched control population (n = 850) from the Study of Health in Pomerania cohort (SHIP Trend Cohort).
   Results
   Patients suffering from BD had a T2D prevalence of 7%, which was not significantly different from the control group (6%). Fasting glucose and impaired glucose tolerance were, contrary to our hypothesis, more often pathological in controls than in BD patients. Nondiabetic and diabetic bipolar patients significantly differed in age, BMI, number of depressive episodes, and disease duration.
   Discussion
   When controlled for BMI, in our study there was no significantly increased rate of T2D in BD. We thus suggest that overweight and obesity might be mediating the association between BD and diabetes. Underlying causes could be shared risk genes, medication effects, and lifestyle factors associated with depressive episodes. As the latter two can be modified, attention should be paid to weight changes in BD by monitoring and taking adequate measures to prevent the alarming loss of life years in BD patients.
C1 [Kittel-Schneider, Sarah; Reif, Andreas] Goethe Univ, Univ Hosp, Dept Psychiat Psychosomat Med & Psychotherapy, Frankfurt, Germany.
   [Kittel-Schneider, Sarah; Bury, Daniel] Julius Maximilians Univ Wurzburg, Univ Hosp, Dept Psychiat Psychosomat Med & Psychotherapy, Wurzburg, Germany.
   [Bury, Daniel] Kbo Isar Amper Klinikum, Dept Psychiat & Psychotherapy Munich East, Haar, Germany.
   [Leopold, Karolina; Haack, Sara; Bauer, Michael; Pfeiffer, Steffi; Sauer, Cathrin; Pfennig, Andrea] Tech Univ Dresden, Fac Med, Carl Gustav Carus Univ Hosp, Dept Psychiat & Psychotherapy, Dresden, Germany.
   [Leopold, Karolina] Charite, Vivantes Hosp Urban, Dept Psychiat Psychotherapy & Psychosomat, Berlin, Germany.
   [Leopold, Karolina] Charite, Vivantes Hosp Friedrichshain, Berlin, Germany.
   [Voelzke, Henry] Univ Med Greifswald, Inst Community Med, Greifswald, Germany.
   [Grabe, Hans-Joergen] Univ Med Greifswald, Dept Psychiat & Psychotherapy, Greifswald, Germany.
C3 Goethe University Frankfurt; Goethe University Frankfurt Hospital;
   University of Wurzburg; Technische Universitat Dresden; Carl Gustav
   Carus University Hospital; Berlin Institute of Health; Free University
   of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin
   Berlin; Berlin Institute of Health; Free University of Berlin; Humboldt
   University of Berlin; Charite Universitatsmedizin Berlin; Universitat
   Greifswald; Greifswald Medical School; Universitat Greifswald;
   Greifswald Medical School
RP Reif, A (corresponding author), Goethe Univ, Univ Hosp, Dept Psychiat Psychosomat Med & Psychotherapy, Frankfurt, Germany.
EM Andreas.reif@kgu.de
RI Kittel-Schneider, Sarah/ABT-1407-2022
FU medical faculty of the Technische Universitat Dresden; Federal Ministry
   of Education and Research [01ZZ9603, 01ZZ0103, 01ZZ0403]; Ministry of
   Cultural Affairs; Social Ministry of the Federal State of
   Mecklenburg-West Pomerania; University of Frankfurt
FX This study has been supported by a grant of the medical faculty of the
   Technische Universitat Dresden to SH and AP. This publication was funded
   by the University of Frankfurt. SHIP is part of the Community Medicine
   Research net of the University of Greifswald, Germany, which is funded
   by the Federal Ministry of Education and Research (grants no. 01ZZ9603,
   01ZZ0103, and 01ZZ0403), the Ministry of Cultural Affairs and the Social
   Ministry of the Federal State of Mecklenburg-West Pomerania.
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NR 71
TC 9
Z9 9
U1 1
U2 11
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-0640
J9 FRONT PSYCHIATRY
JI Front. Psychiatry
PD APR 22
PY 2020
VL 11
AR 314
DI 10.3389/fpsyt.2020.00314
PG 11
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA LL5MA
UT WOS:000531600800001
PM 32390884
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Liang, YJ
   Zhou, S
   Chen, XH
   Yu, LB
   Zhang, DL
   Lin, CL
AF Liang, Yinji
   Zhou, Shuang
   Chen, Xinhe
   Yu, Lebing
   Zhang, Dongling
   Lin, Chenli
TI Gut Microbiome and Nonalcoholic Fatty Liver Disease (NAFLD) Implications
   for Nursing Care of Individuals Living With Chronic Metabolic Diseases
SO GASTROENTEROLOGY NURSING
LA English
DT Article
ID DEPRESSION; DIET; HEALTH
AB At present, the incidence of nonalcoholic fatty liver disease (NAFLD) in adults is increasing year by year and at a younger age. Evidence-based healthcare has confirmed that NAFLD is closely related to obesity, cardiovascular disease, type 2 diabetes, metabolic syndrome, and other chronic metabolic diseases. Despite the growing prevalence of NAFLD, little is known about symptoms for patients at risk of NAFLD progression, thus preventing healthcare providers from intervening at an early stage. In addition, these symptoms usually cause problems for patients to cope with other chronic metabolic diseases. Symptoms may have a biological basis; especially as the changes of gut microbes may affect the symptoms of metabolic diseases. This article aims to describe the new role of gut microbes in the development of NAFLD, focusing on the potential relationship between gut microbes and symptoms of NAFLD, as well as the mechanism of action of the "gut-liver-brain" axis. This information can be useful in developing precise nursing interventions for NAFLD patients, restoring the "health" of gut microbes, and alleviating the symptom burden of chronic metabolic disease in NAFLD.
C1 [Liang, Yinji; Zhou, Shuang; Yu, Lebing] Jinan Univ, Sch Nursing, Guangzhou, Guangdong, Peoples R China.
   [Chen, Xinhe] Jinan Univ, Sch Stomatol, Guangzhou, Guangdong, Peoples R China.
   [Zhang, Dongling; Lin, Chenli] Jinan Univ, Sch Med, 601 Huangpu Ave West, Guangzhou 510632, Guangdong, Peoples R China.
C3 Jinan University; Jinan University; Jinan University
RP Lin, CL (corresponding author), Jinan Univ, Sch Med, 601 Huangpu Ave West, Guangzhou 510632, Guangdong, Peoples R China.
EM tlyj@hotmail.com; 254510330@qq.com; 996319908@qq.com; 1600954220@qq.com;
   444392057@qq.com; igene@foxmail.com
RI liang, yinji/AGV-5846-2022; Chen, Xinhe/KKL-9119-2024
FU Traditional Chinese Medicine Bureau of Guangdong in China [20161065,
   20201075]; National Health and Family Planning Commission of Guangdong
   in China [A2016583, A2017228, A2017140, A2020137]; Jinan University
   [JG2020080]; Teaching Quality and Teaching Reform project of
   Undergraduate University of Guangdong in China [214 [2017]];
   Undergraduate Training Programs for Innovation and Entrepreneurship of
   Jinan University in China [CX20157, CX20145, S201910559055]
FX This work was supported in part by Traditional Chinese Medicine Bureau
   of Guangdong in China (no. 20161065 and 20201075), National Health and
   Family Planning Commission of Guangdong in China (no. A2016583,
   A2017228, A2017140, and A2020137), the 22nd Batch of Teaching Reform
   Research Projects of Jinan University (JG2020080), Teaching Quality and
   Teaching Reform project of Undergraduate University of Guangdong in
   China (no. 214 [2017]), and Undergraduate Training Programs for
   Innovation and Entrepreneurship of Jinan University in China (no.
   CX20157, CX20145, and S201910559055).
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NR 37
TC 2
Z9 3
U1 2
U2 22
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1042-895X
EI 1538-9766
J9 GASTROENTEROL NURS
JI Gastroenterol. Nurs.
PD JAN-FEB
PY 2021
VL 44
IS 1
BP E18
EP E22
DI 10.1097/SGA.0000000000000545
PG 5
WC Gastroenterology & Hepatology; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Gastroenterology & Hepatology; Nursing
GA QA1HO
UT WOS:000613201000005
PM 33538526
DA 2025-06-11
ER

PT J
AU Margiotta, DPE
   Basta, F
   Dolcini, G
   Batani, V
   Navarini, L
   Afeltra, A
AF Margiotta, Domenico Paolo Emanuele
   Basta, Fabio
   Dolcini, Giulio
   Batani, Veronica
   Navarini, Luca
   Afeltra, Antonella
TI The relation between, metabolic syndrome and quality of life in patients
   with Systemic Lupus Erythematosus
SO PLOS ONE
LA English
DT Article
ID CORONARY-HEART-DISEASE; CARDIOVASCULAR RISK; INSULIN-RESISTANCE;
   PHYSICAL-ACTIVITY; HEALTH; ASSOCIATION; VALIDATION; DEPRESSION; OBESITY;
   WOMEN
AB Introduction
   Systemic Lupus Erythematosus (SLE) is associated to an increased prevalence of Metabolic Syndrome (MeS) and to a reduction of Quality of Life (QoL). The aim of this study is to evaluate the association between MeS and QoL in SLE.
   Methods
   SLE patients were consecutively enrolled in a cross sectional study. MeS was defined according to IFD definition. Therapy with glucocorticoids (GC) and antimalarial was analyzed as cumulative years of exposure. We used a cut off of 7.5 mg of prednisone to define high daily dose of GC. QoL was quantified using SF-36. We used BDI and HAM-H to assess symptoms of mood disorders. Fatigue was evaluated using Facit-Fatigue, physical activity using IPAQ, sleep quality using PSQI and alexithymia using TAS-20.
   Results
   We enrolled 100 SLE patients. MeS prevalence was 34%. Patients with MeS presented reduced scores in SF-36 MCS and PCS compared to patients without MeS (p 0.03 and p 0.004). BDI and HAM-H score were significantly higher in patients meeting MeS criteria compared to subjects without MeS (p 0.004, p 0.02). These results were confirmed after adjustment for confounders. Compared to patients without MeS, those with MeS presented higher age, lower education level, higher recent SELENA-SLEDAI, higher number of flares, increased SDI, longer cumulative exposure to high dose GC and shorter duration of antimalarial therapy. In the multiple logistic regression model, the variable associated to the Odds Ratio of having MeS were: the average of recent SELENA-SLEDAI (OR 1.15 p 0.04), the years of exposure to high dose of GC (OR 1.18 p 0.004), the years of exposure to antimalarials (OR 0.82 p 0.03) and the BDI score (OR 1.1 p 0.005).
   Conclusion
   A modern management of SLE should not miss to take all the possible measures to ensure an adequate QoL to SLE patients, with particular attention to those affected by MeS.
C1 [Margiotta, Domenico Paolo Emanuele; Basta, Fabio; Dolcini, Giulio; Batani, Veronica; Navarini, Luca; Afeltra, Antonella] Univ Campus Biomed Roma, Unit Allergol Clin Immunol & Rheumatol, Romeu, Italy.
RP Margiotta, DPE (corresponding author), Univ Campus Biomed Roma, Unit Allergol Clin Immunol & Rheumatol, Romeu, Italy.
EM d.margiotta@unicampus.it
RI Navarini, Luca/A-7987-2011; batani, veronica/JJF-1230-2023; Margiotta,
   Domenico Paolo Emanuele/G-5769-2018
OI Margiotta, Domenico Paolo Emanuele/0000-0002-3597-8645
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NR 60
TC 21
Z9 21
U1 0
U2 6
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD NOV 7
PY 2017
VL 12
IS 11
AR e0187645
DI 10.1371/journal.pone.0187645
PG 17
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Science & Technology - Other Topics
GA FL9KF
UT WOS:000414572100028
PM 29112985
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Danner, U
   Macheiner, T
   Avian, A
   Lackner, N
   Fellendorf, F
   Birner, A
   Bengesser, SA
   Platzer, M
   Kapfhammer, HP
   Reininghaus, E
AF Danner, Ursula
   Macheiner, Tanja
   Avian, Alexander
   Lackner, Nina
   Fellendorf, Frederike
   Birner, Armin
   Bengesser, Susanne A.
   Platzer, Martina
   Kapfhammer, Hans-Peter
   Reininghaus, Eva
TI Acceptance of the Use of Pedometers in Individuals with Bipolar Disorder
SO FORTSCHRITTE DER NEUROLOGIE PSYCHIATRIE
LA English
DT Article
DE bipolar disorders; pedometer; physical activity; motivational
   intervention
ID RANDOMIZED CONTROLLED-TRIAL; QUALITY-OF-LIFE; PHYSICAL-ACTIVITY;
   METABOLIC SYNDROME; MENTAL-ILLNESS; RATING-SCALE; DEPRESSION; EXERCISE;
   METAANALYSIS; PEOPLE
AB Before patients with bipolar disorder (BD) can begin to perform balanced physical activity, they have to overcome many difficulties. The aim of this study was to examine the acceptance of pedometers as a self-assessment tool in people with BD. Patients who participated in an intervention study with body-oriented groups and psychoeducation groups at the Medical University of Graz/Department of Psychiatry were invited to use pedometers on a daily basis and keep pedometer diaries over a period of 24 weeks. Most of the patients were satisfied with the pedometers and found them helpful for their health. The difficulties in the study were to recruit patients for this exercise trial, their lack of adherence to the programme and a high dropout rate. Out of the 130 invited patients, 41 came to the baseline investigation, 27 of them took part in the group interventions and 14 used pedometers and handed in the pedometer diaries. For clinical practice, specific motivational interventions are recommended to stimulate individuals with BD to engage in regular physical exercise.
C1 [Danner, Ursula] FH Joanneum GmbH, Physiotherapie, Graz, Austria.
   [Danner, Ursula; Macheiner, Tanja; Lackner, Nina; Fellendorf, Frederike; Birner, Armin; Bengesser, Susanne A.; Platzer, Martina; Kapfhammer, Hans-Peter; Reininghaus, Eva] Med Univ Graz, Psychiatrie & Psychotherapeut Med, Graz, Austria.
   [Avian, Alexander] Medizin Univ Graz, Inst Med Informat Stat & Dokumenta, Graz, Austria.
C3 Medical University of Graz
RP Danner, U (corresponding author), Med Univ Graz, Psychiatrie & Psychotherapeut Med, Graz, Austria.
EM ursula.danner@gmx.at
OI Avian, Alexander/0000-0003-1084-5763; Danner,
   Ursula/0000-0002-8477-3881; Fellendorf, Frederike/0000-0001-7215-3848
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NR 50
TC 1
Z9 1
U1 0
U2 5
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0720-4299
EI 1439-3522
J9 FORTSCHR NEUROL PSYC
JI Forschritte Neurol. Psychiatr.
PD FEB
PY 2017
VL 85
IS 2
BP 86
EP 91
DI 10.1055/s-0042-124506
PG 6
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA EP3JG
UT WOS:000397278000019
PM 28235210
DA 2025-06-11
ER

PT J
AU Ruff, JS
   Suchy, AK
   Hugentobler, SA
   Sosa, MM
   Schwartz, BL
   Morrison, LC
   Gieng, SH
   Shigenaga, MK
   Potts, WK
AF Ruff, James S.
   Suchy, Amanda K.
   Hugentobler, Sara A.
   Sosa, Mirtha M.
   Schwartz, Bradley L.
   Morrison, Linda C.
   Gieng, Sin H.
   Shigenaga, Mark K.
   Potts, Wayne K.
TI Human-relevant levels of added sugar consumption increase female
   mortality and lower male fitness in mice
SO NATURE COMMUNICATIONS
LA English
DT Article
ID MAGNIFIES INBREEDING DEPRESSION; FRUCTOSE CORN SYRUP;
   METABOLIC-SYNDROME; UNITED-STATES; RISK; BEVERAGES; EPIDEMIC; GLUCOSE
AB Consumption of added sugar has increased over recent decades and is correlated with numerous diseases. Rodent models have elucidated mechanisms of toxicity, but only at concentrations beyond typical human exposure. Here we show that comparatively low levels of added sugar consumption have substantial negative effects on mouse survival, competitive ability, and reproduction. Using Organismal Performance Assays-in which mice fed human-relevant concentrations of added sugar (25% kcal from a mixture of fructose and glucose, modeling high fructose corn syrup) and control mice compete in seminatural enclosures for territories, resources and mates-we demonstrate that fructose/glucose-fed females experience a twofold increase in mortality while fructose/glucose-fed males control 26% fewer territories and produce 25% less offspring. These findings represent the lowest level of sugar consumption shown to adversely affect mammalian health. Clinical defects of fructose/glucose-fed mice were decreased glucose clearance and increased fasting cholesterol. Our data highlight that physiological adversity can exist when clinical disruptions are minor, and suggest that Organismal Performance Assays represent a promising technique for unmasking negative effects of toxicants.
C1 [Ruff, James S.; Suchy, Amanda K.; Hugentobler, Sara A.; Sosa, Mirtha M.; Schwartz, Bradley L.; Morrison, Linda C.; Potts, Wayne K.] Univ Utah, Dept Biol, Salt Lake City, UT 84112 USA.
   [Suchy, Amanda K.] Arizona State Univ, Sch Life Sci, Tempe, AZ 85287 USA.
   [Gieng, Sin H.; Shigenaga, Mark K.] Childrens Hosp Oakland, Res Inst, Nutr & Metab Ctr, Oakland, CA 94609 USA.
C3 Utah System of Higher Education; University of Utah; Arizona State
   University; Arizona State University-Tempe; Children's Hospital Oakland
   Research Institute; University of California System; University of
   California San Francisco; UCSF Medical Center; UCSF Benioff Children's
   Hospital Oakland
RP Ruff, JS (corresponding author), Univ Utah, Dept Biol, 257 South 1400 East, Salt Lake City, UT 84112 USA.
EM j.ruff@utah.edu
RI Gieng, John/AAX-8207-2020
OI Ruff, James/0000-0002-8292-8640; Suchy, Amanda/0000-0001-7409-1652;
   Hugentobler, Sara/0000-0003-1239-7909; Potts, Wayne/0000-0003-4137-0326;
   Gieng, John/0000-0002-1834-9708
FU NIH [RO1-GM039578]; NSF [DEB 09-18969, HRD-1101728]; NSF GK-12
   Educational Outreach Fellowship [DGE 08-41233]; Division Of
   Environmental Biology; Direct For Biological Sciences [0918969] Funding
   Source: National Science Foundation
FX We thank B. Ames for suggesting we apply OPAs to added sugar; D. Dearing
   and A. Torregrossa for aid in experimental design; S. Laverty for
   statistical modelling assistance; P. Ault, S. Ault, D. Pearson and R.
   Tanner for help in data collection; and J. McCann for comments on the
   manuscript. This work was supported by NIH Grant RO1-GM039578 and was
   partially conducted while W.K.P. was supported by NSF Grant DEB
   09-18969. J.S.R. was supported by an NSF GK-12 Educational Outreach
   Fellowship (DGE 08-41233). M.M.S. was supported by the NSF funded
   Western Alliance to Expand Student Opportunities (WAESO (HRD-1101728)).
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NR 31
TC 61
Z9 71
U1 0
U2 31
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 2041-1723
J9 NAT COMMUN
JI Nat. Commun.
PD AUG
PY 2013
VL 4
AR 2245
DI 10.1038/ncomms3245
PG 7
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 209JE
UT WOS:000323751000003
PM 23941916
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Rabby, MG
   Rahman, MH
   Islam, MN
   Kamal, MM
   Biswas, M
   Bonny, M
   Hasan, MM
AF Rabby, Md. Golam
   Rahman, Md. Hafizur
   Islam, Md. Numan
   Kamal, Md. Mostafa
   Biswas, Mrityunjoy
   Bonny, Mantasa
   Hasan, Md. Mahmudul
TI In silico identification and functional prediction of
   differentially expressed genes in South Asian populations associated
   with type 2 diabetes
SO PLOS ONE
LA English
DT Article
ID MELLITUS; STRESS; SUSCEPTIBILITY; MECHANISMS; RESISTANCE; MICRORNAS;
   CARCINOMA
AB Type 2 diabetes (T2D) is one of the major metabolic disorders in humans caused by hyperglycemia and insulin resistance syndrome. Although significant genetic effects on T2D pathogenesis are experimentally proved, the molecular mechanism of T2D in South Asian Populations (SAPs) is still limited. Hence, the current research analyzed two Gene Expression Omnibus (GEO) and 17 Genome-Wide Association Studies (GWAS) datasets associated with T2D in SAP to identify DEGs (differentially expressed genes). The identified DEGs were further analyzed to explore the molecular mechanism of T2D pathogenesis following a series of bioinformatics approaches. Following PPI (Protein-Protein Interaction), 867 potential DEGs and nine hub genes were identified that might play significant roles in T2D pathogenesis. Interestingly, CTNNB1 and RUNX2 hub genes were found to be unique for T2D pathogenesis in SAPs. Then, the GO (Gene Ontology) showed the potential biological, molecular, and cellular functions of the DEGs. The target genes also interacted with different pathways of T2D pathogenesis. In fact, 118 genes (including HNF1A and TCF7L2 hub genes) were directly associated with T2D pathogenesis. Indeed, eight key miRNAs among 2582 significantly interacted with the target genes. Even 64 genes were downregulated by 367 FDA-approved drugs. Interestingly, 11 genes showed a wide range (9-43) of drug specificity. Hence, the identified DEGs may guide to elucidate the molecular mechanism of T2D pathogenesis in SAPs. Therefore, integrating the research findings of the potential roles of DEGs and candidate drug-mediated downregulation of marker genes, future drugs or treatments could be developed to treat T2D in SAPs.
C1 [Rabby, Md. Golam; Islam, Md. Numan; Kamal, Md. Mostafa; Bonny, Mantasa; Hasan, Md. Mahmudul] Jashore Univ Sci & Technol, Dept Nutr & Food Technol, Khulna, Bangladesh.
   [Rahman, Md. Hafizur; Biswas, Mrityunjoy] Jashore Univ Sci & Technol, Dept Agro Prod Proc Technol, Khulna, Bangladesh.
   [Rahman, Md. Hafizur] Khulna Agr Univ, Fac Food Sci & Safety, Dept Qual Control & Safety Management, Khulna, Bangladesh.
RP Hasan, MM (corresponding author), Jashore Univ Sci & Technol, Dept Nutr & Food Technol, Khulna, Bangladesh.; Biswas, M (corresponding author), Jashore Univ Sci & Technol, Dept Agro Prod Proc Technol, Khulna, Bangladesh.
EM hasanm_agb@yahoo.com; biswasbari@yahoo.com
RI RAHMAN, MD HAFIZUR/GNM-9340-2022; Hasan, Md. Mahmudul/JCP-0290-2023;
   Kamal, Md. Mostafa/KJM-2085-2024
OI Hasan, PhD, Md. Mahmudul/0000-0003-2000-380X; Raaby, Md.
   Golam/0000-0003-4627-3947; Kamal, Md. Mostafa/0000-0002-0266-4711;
   Rahman, PhD, Md. Hafizur/0000-0002-1677-2764
FU ICT division, Ministry of Posts, Telecommunications and Information
   Technology, Government of the People's Republic of Bangladesh
FX The research work was done with the financial support from ICT division,
   Ministry of Posts, Telecommunications and Information Technology,
   Government of the People's Republic of Bangladesh. The funders had no
   role in study design, data collection and analysis, decision to publish,
   or preparation of the manuscript.
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NR 74
TC 4
Z9 4
U1 0
U2 0
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD DEC 14
PY 2023
VL 18
IS 12
AR e0294399
DI 10.1371/journal.pone.0294399
PG 19
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA HI0J8
UT WOS:001158744900009
PM 38096208
OA gold
DA 2025-06-11
ER

PT J
AU Aurigemma, C
   Scalone, G
   Fattorossi, A
   Sestito, A
   Lanza, GA
   Crea, F
AF Aurigemma, Cristina
   Scalone, Giancarla
   Fattorossi, Andrea
   Sestito, Alfonso
   Lanza, Gaetano Antonio
   Crea, Filippo
TI Adenosine inhibition of adenosine diphosphate and thrombin-induced
   monocyte-platelet aggregates in cardiac syndrome X
SO THROMBOSIS RESEARCH
LA English
DT Article
DE Adenosine; Adenosine diphosphate; Cardiac syndrome X; Monocyte-platelet
   aggregates; Thrombin
ID CORONARY-ARTERY-DISEASE; IN-VIVO; MYOCARDIAL-ISCHEMIA; RECEPTOR
   EXPRESSION; ANGINA-PECTORIS; MENTAL STRESS; WHOLE-BLOOD; P-SELECTIN;
   EXERCISE; REACTIVITY
AB Introduction: We previously showed that platelet reactivity at rest is increased in patients with cardiac syndrome X (CSX), but that exercise reduces platelet reactivity in these patients. Adenosine was suggested to be involved in this phenomenon. In this study we investigated the effect of adenosine on adenosine diphosphate (ADP) and thrombin-induced platelet reactivity in CSX patients.
   Materials and methods: We studied 15 CSX patients and a control group of 15 healthy subjects. Formation of monocyte-platelet (MONO-PLT) aggregates in vitro was assessed by flow cytometry: 1) at baseline; 2) after ADP (10(-7) M) stimulation alone; 3) after ADP stimulation in presence of adenosine (10(-5) M); 4) after thrombin (10(-11) M) stimulation alone; 5) after thrombin stimulation in presence of adenosine.
   Results: In non stimulated samples there were no relevant differences between the two groups in cytometry variables. Compared to controls, ADP induced a higher increase in MONO-PLT aggregates in CSX patients (P < 0.01), which was significantly inhibited by adenosine (P < 0.01). Thrombin also induced a greater increase in MONO-PLT aggregates in CSX patients (P < 0.001), which was also significantly blunted by adenosine. Similar trends were observed for platelet CD41 (glycoprotein IIb-IIIa) receptor and for monocyte receptors CD142 ad CD162 in MONO-PLT aggregates.
   Conclusions: In CSX patients platelet reactivity is increased at rest, compared to healthy controls. Pre-incubation with adenosine reduces the agonist-induced platelet hyper-reactivity in these patients, suggesting that adenosine may be involved in the reduction of platelet reactivity observed in CSX patients after exercise in our previous study. (C) 2009 Elsevier Ltd. All rights reserved.
C1 [Lanza, Gaetano Antonio] Univ Cattolica Sacro Cuore, Ist Cardiol, I-00168 Rome, Italy.
   Univ Cattolica Sacro Cuore, Ist Ginecol, I-00168 Rome, Italy.
C3 Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli;
   Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli
RP Lanza, GA (corresponding author), Univ Cattolica Sacro Cuore, Ist Cardiol, Largo A Gemelli 8, I-00168 Rome, Italy.
EM g.a.lanza@rm.unicatt.it
RI Lanza, Gaetano/AAC-2660-2019; Crea, Filippo/AAC-9754-2022; Aurigemma,
   Cristina/J-9958-2018; BURZOTTA, FRANCESCO/K-1004-2018
OI Aurigemma, Cristina/0000-0001-6391-422X; BURZOTTA,
   FRANCESCO/0000-0002-6569-9401
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NR 28
TC 6
Z9 6
U1 0
U2 0
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0049-3848
J9 THROMB RES
JI Thromb. Res.
PD MAY
PY 2009
VL 124
IS 1
BP 116
EP 120
DI 10.1016/j.thromres.2008.12.041
PG 5
WC Hematology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Hematology; Cardiovascular System & Cardiology
GA 446UX
UT WOS:000266148000022
PM 19185336
DA 2025-06-11
ER

PT J
AU Boudik, F
   Anger, Z
   Aschermann, M
   Vojácek, J
   Tomecková, M
AF Boudik, F
   Anger, Z
   Aschermann, M
   Vojácek, J
   Tomecková, M
TI Dipyridamole body surface potential mapping:: Noninvasive
   differentiation of syndrome X from coronary artery disease
SO JOURNAL OF ELECTROCARDIOLOGY
LA English
DT Article
DE body surface potential mapping; dipyridamole; coronary artery disease;
   syndrome X
ID ACUTE MYOCARDIAL-INFARCTION; ANGINA-PECTORIS; CHEST PAIN; MICROVASCULAR
   ANGINA; INSULIN-RESISTANCE; SEGMENT CHANGES; ARTERIOGRAMS; ANGIOGRAMS;
   PERFUSION; EXERCISE
AB Up to 20% to 30% of patients with angina and abnormal stress test have normal coronary arteries at angiography or syndrome X (Sy X). We tested whether body surface potential mapping (BSPM) with intravenous dipyridamole could differentiate patients with Sy X from patients with corollary artery disease (CAD). We compared the effects of intravenous dipyridamole (0.28 mg/kg over 4 min) on BSPM in 17 healthy volunteers (controls) and in 2 groups of patients with angina and abnormal ergometric tests who were referred for angiography: 27 patients with obstructive disease (greater than or equal to70% diameter stenosis) in the CAD group, and 17 patients with Sy X. Control subjects were easily differentiated from patients with CAD or Sy X by markedly smaller baseline BSPM DeltaST-T less than or equal to LSD departure areas (P<.001), but the Sy X and CAD groups had similar ST-T departure areas. The average potential integral difference after dipyridamole (APID) differentiated Sy X and CAD patients: the mean APID increased in patients with Sy X and trended negative in the CAD group. The APID(20%-40%) (integrated over 20% to 40% of the ST-T interval) mean value was 0.59 +/- 0.67 mu Vs in the Sy X group and -0.18 +/- 0.59 mu Vs in the CAD group (P<.01). At a threshold APID(20%-40) > 0.17 muVs, the sensitivity and specificity for Sy X was 71% and 78%, respectively; the area under the receiver operating characteristic curve was 0.79 (95% CI 0.64, 0.93). Dipyridamole BSPM is a promising noninvasive diagnostic modality to differentiate patients with Sy X from those with CAD.
C1 Charles Univ Hosp, Dept Internal Med 2, Prague 12808 2, Czech Republic.
C3 Charles University Prague; General University Hospital Prague
RP Charles Univ Hosp, Dept Internal Med 2, U Nemocnice 2, Prague 12808 2, Czech Republic.
EM fboud@lfl.cuni.cz
RI Vojacek, Jan/N-5774-2017
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NR 46
TC 5
Z9 6
U1 0
U2 1
PU CHURCHILL LIVINGSTONE INC MEDICAL PUBLISHERS
PI PHILADELPHIA
PA CURTIS CENTER, INDEPENDENCE SQUARE WEST, PHILADELPHIA, PA 19106-3399 USA
SN 0022-0736
EI 1532-8430
J9 J ELECTROCARDIOL
JI J. Electrocardiol.
PD JUL
PY 2002
VL 35
IS 3
BP 181
EP 191
DI 10.1054/jelc.2002.33762
PG 11
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 574VT
UT WOS:000176910800002
PM 12122608
DA 2025-06-11
ER

PT J
AU Machado, FR
   Boeira, SP
   Bortolotto, VC
   Araujo, SM
   Poetini, MR
   Viana, CE
   Prigol, M
   Souza, LC
   de Gomes, MG
AF Machado, Franciele Romero
   Boeira, Silvana Peterini
   Bortolotto, Vandreza Cardoso
   Araujo, Stifani Machado
   Poetini, Marcia Rosula
   Viana, Cristini Escobar
   Prigol, Marina
   Souza, Leandro Cattelan
   de Gomes, Marcelo Gomes
TI HDAC3 inhibition protects against peripheral and central alterations in
   an animal model of obesity
SO PHARMACOLOGICAL REPORTS
LA English
DT Article
DE Epigenetic; Metabolism; Nutrition; Neuroinflammation; Obesity
ID INSULIN-RESISTANCE; HISTONE DEACETYLASES; DIFFERENTIATION; LEPTIN;
   MEMORY; DELETION
AB BackgroundObesity is a multifactorial disease with epigenetic manifestations that increases the prevalence of associated comorbidities such as metabolic syndrome, cardiovascular dysfunction, and major depression disorder. Given the aforementioned, a search for new pharmacological alternatives for the treatment of this disease is necessary. The current study aimed to evaluate the effects of histone deacetylase-3 (HDAC3) inhibition caused by RGFP966 (a benzamide-type HDAC inhibitor selective for HDAC3) administration, in an animal model of obesity induced by high-fat diet (HFD).MethodsAdult male mice C57BJ/6 were fed with a normal pellet diet (NPD) or HFD for 120 days. The HDAC3 inhibitor (RGFP966; 10 mg/kg; sc) was administered on the 91st to 120th day of the experiment (per 30 days). After the last inhibitor administration, animals were euthanized, blood was collected, and the hippocampus was removed for biochemical determinations.ResultsIn an overall manner, the administration of RGFP966 protected against changes in body weight gain, glucose, insulin, lipid profile, adipokines, and increase of hippocampal proinflammatory cytokines levels caused by HFD.ConclusionTherefore, HDAC3 inhibition can represent a promising pharmacological target for the treatment of obesity.
C1 [Machado, Franciele Romero; Boeira, Silvana Peterini; Bortolotto, Vandreza Cardoso; Araujo, Stifani Machado; Poetini, Marcia Rosula; Viana, Cristini Escobar; Prigol, Marina; Souza, Leandro Cattelan; de Gomes, Marcelo Gomes] Fed Univ Pampa, Lab Pharmacol & Toxicol Evaluat Appl Bioact Mol, LaftamBio Pampa, Campus Itaqui, BR-97650000 Itaqui, RS, Brazil.
C3 Universidade Federal do Pampa
RP de Gomes, MG (corresponding author), Fed Univ Pampa, Lab Pharmacol & Toxicol Evaluat Appl Bioact Mol, LaftamBio Pampa, Campus Itaqui, BR-97650000 Itaqui, RS, Brazil.
EM marcelogomesdegomes@hotmail.com
RI de Gomes, Marcelo/AAA-2432-2019; Souza, Leandro/AAS-2193-2020; Boeira,
   Silvana/LWJ-3502-2024; Prigol, Marina/E-9316-2015
OI Gomes de Gomes, Marcelo/0000-0001-9017-5979
FU FAPERGS [16/2551-0000526-5]; CNPq [430841/2016-7]; Coordination for the
   Improvement of Higher Education Personnel-Brazil (CAPES) [001]; CAPES;
   Postgraduate Program in Biochemistry of the Federal University of Pampa
FX This research was supported by FAPERGS [#16/2551-0000526-5 (PRONUPEQ)
   and CNPq (#430841/2016-7 (Universal)]. This study was financed in part
   by the Coordination for the Improvement of Higher Education
   Personnel-Brazil (CAPES)-Finance Code 001. M.G.G thanks CAPES, P.B.M.C,
   and the Postgraduate Program in Biochemistry of the Federal University
   of Pampa for the postdoctoral research fellowship (PDPG program).
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NR 30
TC 0
Z9 0
U1 1
U2 4
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1734-1140
EI 2299-5684
J9 PHARMACOL REP
JI Pharmacol. Rep.
PD OCT
PY 2023
VL 75
IS 5
BP 1177
EP 1186
DI 10.1007/s43440-023-00528-7
EA SEP 2023
PG 10
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA S6IQ9
UT WOS:001064515200001
PM 37698830
DA 2025-06-11
ER

PT J
AU Zemel, MB
AF Zemel, Michael B.
TI Proposed Role of Calcium and Dairy Food Components in Weight Management
   and Metabolic Health
SO PHYSICIAN AND SPORTSMEDICINE
LA English
DT Article
DE calcium; dairy foods; adipocyte; obesity; whey
ID DENSITY-LIPOPROTEIN PARTICLES; INSULIN-RESISTANCE SYNDROME; VITAMIN-D
   SUPPLEMENTATION; BODY-MASS INDEX; DIETARY CALCIUM; ADIPOSE-TISSUE; FAT
   LOSS; 1-ALPHA,25-DIHYDROXYVITAMIN D-3; INTRACELLULAR CALCIUM; ADIPOCYTE
   METABOLISM
AB Dietary calcium and dairy foods have demonstrated an anti obesity effect in animal studies, observational and population studies, and randomized clinical trials. Moreover, there is a strong theoretical framework to explain the effects of dietary calcium on energy metabolism. The supporting mechanisms include dietary calcium-correcting suboptimal calcium intakes, thereby preventing the endocrine response (parathyroid hormone [PTH] and calcitriol), which favors adipocyte energy storage and inhibits adipocyte loss via apoptosis. Dietary calcium appears to further promote energy loss via formation of calcium soaps in the gastrointestinal tract and thereby modestly reduces net energy absorption. Dietary calcium appears to be responsible for approximately 50% of the anti obesity bioactivity of dairy foods. The additional dairy bioactivity has not been fully identified, but is primarily localized in whey protein. The major components are the angiotensin-converting enzyme (ACE) inhibitor activity of whey proteins and the high concentration of leucine in whey. This high leucine content appears to be primarily responsible for the repartitioning of dietary energy from adipose tissue to skeletal muscle during weight loss, resulting in greater preservation of skeletal muscle and accelerated loss of adipose tissue during negative energy balance. Finally, high-calcium diets suppress obesity-induced oxidative and inflammatory stress independently from its role in modulating adiposity; these effects are similarly augmented by other dairy food components. However, the number of randomized clinical trials conducted is still modest, and a small number have not confirmed significant effects in weight management. Thus, the protective effects of dairy foods against obesity and its comorbidities are promising, but warrant further large-scale studies.
C1 Univ Tennessee, Inst Nutr, Knoxville, TN 37996 USA.
C3 University of Tennessee System; University of Tennessee Knoxville
RP Zemel, MB (corresponding author), Univ Tennessee, Inst Nutr, Knoxville, TN 37996 USA.
EM mzemel@utk.edu
OI Zemel, Michael/0000-0003-4104-5750
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NR 98
TC 54
Z9 65
U1 0
U2 21
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0091-3847
EI 2326-3660
J9 PHYSICIAN SPORTSMED
JI Physician Sportsmed.
PD JUN
PY 2009
VL 37
IS 2
BP 29
EP 39
DI 10.3810/psm.2009.06.1707
PG 11
WC Primary Health Care; Orthopedics; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Orthopedics; Sport Sciences
GA V17IM
UT WOS:000207930900016
PM 20048507
DA 2025-06-11
ER

PT J
AU Phillips, DIW
   Walker, BR
   Reynolds, RM
   Flanagan, DEH
   Wood, PJ
   Osmond, C
   Barker, DJP
   Whorwood, CB
AF Phillips, DIW
   Walker, BR
   Reynolds, RM
   Flanagan, DEH
   Wood, PJ
   Osmond, C
   Barker, DJP
   Whorwood, CB
TI Low birth weight predicts elevated plasma cortisol concentrations in
   adults from 3 populations
SO HYPERTENSION
LA English
DT Article
DE hypothalamus; cortisol; adrenal glands; blood pressure
ID PITUITARY-ADRENOCORTICAL AXIS; INSULIN-RESISTANCE SYNDROME; CORONARY
   HEART-DISEASE; BLOOD-PRESSURE; FETAL; STRESS; GROWTH; SECRETION;
   OBESITY; DEATH
AB Low birth weight is linked with raised blood pressure in adult life. Recent evidence has suggested that a neuroendocrine disturbance involving the hypothalamic-pituitary-adrenal axis could mediate this link. We therefore investigated the relation between birth weight and fasting plasma cortisol concentrations and the association of cortisol with current blood pressure in population samples of 165 men and women born in Adelaide, South Australia, from 1975 to 1976, 199 men and women born in Preston, UK, from 1935 to 1943, and 306 women born in East Hertfordshire, UK, from 1923 to 1930. Fasting plasma cortisol was measured in plasma samples obtained between 8 and 10 AM. Blood pressure was measured with an automated sphygmomanometer. Low birth weight was associated with raised fasting plasma cortisol concentrations in all 3 populations. A combined analysis that allowed for differences in the gender composition, age, and body mass index between the studies showed that cortisol concentrations fell by 23.9 nmol/L per kilogram increase in birth weight (95% CI 9.6 to 38.2, P<0.001). Fasting plasma cortisol concentrations also correlated positively with the subjects' current blood pressure. However, the association between cortisol and blood pressure was most marked in subjects who were obese (P=0.038 for interaction between body mass index and cortisol, P=0.01 for interaction between waist-to-hip ratio and cortisol), These results show that low birth weight is associated with raised fasting plasma cortisol concentrations. Increased activity of the hypothalamic-pituitary-adrenal axis may link low birth weight with raised blued pressure in adult life.
C1 Univ Southampton, MRC, Environm Epidemiol Unit, Southampton, Hants, England.
   Univ Southampton, Endocrinol & Metab Unit, Southampton, Hants, England.
   Southampton Gen Hosp, Reg Endocrine Unit, Southampton SO9 4XY, Hants, England.
   Univ Edinburgh, Western Gen Hosp, Dept Med Sci, Edinburgh, Midlothian, Scotland.
C3 University of Southampton; University of Southampton; University of
   Southampton; University of Edinburgh
RP Phillips, DIW (corresponding author), Southampton Gen Hosp, MRC Unit, Tremona Rd, Southampton SO16 6YD, Hants, England.
RI Barker, David/A-5671-2013; Reynolds, Rebecca M/C-3044-2008
OI Reynolds, Rebecca M/0000-0001-6226-8270; Osmond,
   Clive/0000-0002-9054-4655
CR [Anonymous], [No title captured]
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NR 23
TC 314
Z9 340
U1 0
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0194-911X
J9 HYPERTENSION
JI Hypertension
PD JUN
PY 2000
VL 35
IS 6
BP 1301
EP 1306
DI 10.1161/01.HYP.35.6.1301
PG 6
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 327RN
UT WOS:000087806700024
PM 10856281
OA Bronze
DA 2025-06-11
ER

PT J
AU Yagmur, J
   Açikgöz, N
   Cansel, M
   Ermis, N
   Karakus, Y
   Kurtoglu, E
AF Yagmur, Julide
   Acikgoz, Nusret
   Cansel, Mehmet
   Ermis, Necip
   Karakus, Yasin
   Kurtoglu, Ertugrul
TI Assessment of the left ventricular systolic function in cardiac syndrome
   X using speckle tracking echocardiography
SO ANATOLIAN JOURNAL OF CARDIOLOGY
LA English
DT Article
DE cardiac syndrome X; speckle tracking echocardiography; strain
ID CHEST-PAIN; MYOCARDIAL DEFORMATION; MICROVASCULAR ANGINA; FOLLOW-UP;
   DYSFUNCTION; PERFUSION; EXERCISE; DISEASE; WOMEN; FLOW
AB Objective: The aim of this study was to evaluate left ventricular (LV) systolic strain by speckle tracking echocardiography (STE) and real-time three-dimensional echocardiography (3-DE) for the early detection of myocardial dysfunction in patients with cardiac syndrome X (CSX).
   Methods: We compared 34 patients with CSX (18 females, mean age 47.9 +/- 10.0 years) with 41 healthy persons as a control group (23 females, mean age 50.6 +/- 9.9 years). Inclusion criteria for CSX were typical angina, a positive exercise ECG stress test, and angiographically documented normal coronary arteries. Exclusion criteria for both groups were hypertension, valvular heart disease, cardiomyopathies, inflammatory diseases, myocarditis, vasculitis, arthropathies, Tietze's syndrome, gastrointestinal diseases, aortic diseases, hormone replacement therapy, arrhythmias, liver diseases, and alcohol use. All subjects underwent two-dimensional STE and 3-DE to assess resting LV function. STE measures were taken from the basal septum, mid-septum, apical septum, apex, apicolateral, mid-lateral, basal lateral, anteroseptal, anterior, anterolateral, inferolateral, inferior, and inferoseptal walls. Student's t-test, Mann-Whitney U test, and chi-square test were used to statistically analyze data.
   Results: LV echo ejection fraction (EF) and systolic wave peak velocity were similar for both groups. Regional mean longitudinal strain (-17.7 +/- 2.5% vs. -19.8 +/- 1.8%; p<0.0001) was significantly lower in patients with CSX than in healthy control patients. However, regional mean circumferential strain values (-22.0 +/- 1.6% vs. -22.2 +/- 2.3%; p=0.78) did not differ significantly between the two groups.
   Conclusion: Significant impairment of LV longitudinal myocardial systolic function was detected with STE in patients with CSX, although normal 3-D EF and tissue Doppler imaging systolic parameters were observed. Arteriosclerosis of small coronary arteries and microvascular dysfunction may affect myocardial longitudinal strain.
C1 [Yagmur, Julide; Acikgoz, Nusret; Cansel, Mehmet; Ermis, Necip; Karakus, Yasin] Inonu Univ, Fac Med, Dept Cardiol, Malatya, Turkey.
   [Kurtoglu, Ertugrul] Malatya State Hosp, Dept Cardiol, Malatya, Turkey.
C3 Inonu University; Malatya State Hospital
RP Yagmur, J (corresponding author), Inonu Univ, Tip Fak, Turgut Ozal Tip Merkezi Arastirma, TR-44100 Malatya, Turkey.; Yagmur, J (corresponding author), Uygulama Hastanesi, Kardiyol Anabilim Dali, TR-44100 Malatya, Turkey.
EM julideyagmur@hotmail.com
RI Ermis, Necip/A-5184-2018; Cansel, Mehmet/ABI-6324-2020
CR Binnetoglu FK, 2015, ANATOL J CARDIOL, V15, P151, DOI 10.5152/akd.2014.5189
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NR 24
TC 4
Z9 4
U1 0
U2 6
PU TURKISH SOC CARDIOLOGY
PI BAHCELIEVLER
PA COBANCESME SANAYI CAD NO 11, NISH ISTANBUL A BLOK KAT 8 NO 47-48,
   YENIBOSNA, BAHCELIEVLER, ISTANBUL 34196, TURKEY
SN 2149-2263
EI 2149-2271
J9 ANATOL J CARDIOL
JI Anat. J. Cardiol.
PD JUN
PY 2016
VL 16
IS 6
BP 419
EP 423
DI 10.5152/AnatolJCardiol.2015.6388
PG 5
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA DX5MN
UT WOS:000384425200007
PM 26680547
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Miesel, A
   Müller-Fielitz, H
   Jöhren, O
   Vogt, FM
   Raasch, W
AF Miesel, Anja
   Mueller-Fielitz, Helge
   Joehren, Olaf
   Vogt, Florian M.
   Raasch, Walter
TI Double blockade of angiotensin II (AT1)-receptors and ACE does not
   improve weight gain and glucose homeostasis better than single-drug
   treatments in obese rats
SO BRITISH JOURNAL OF PHARMACOLOGY
LA English
DT Article
DE metabolic syndrome; obesity; insulin resistance;
   hypothalamic-pituitary-adrenal axis; renin-angiotensin-aldosterone
   system; telmisartan; ramipril
ID CONVERTING-ENZYME-INHIBITION; PITUITARY-ADRENAL AXIS; LONG-TERM
   TREATMENT; RECEPTOR ANTAGONIST; INSULIN SENSITIVITY; TELMISARTAN
   PREVENTS; HYPERTENSIVE PATIENTS; INCREASED EXPRESSION; STRESS
   SENSITIVITY; LIPID-METABOLISM
AB BACKGROUND AND PURPOSE
   Combination therapies are becoming increasingly important for the treatment of high blood pressure. Little is known about whether double blockade of angiotensin II (AT1) receptors and angiotensin-converting enzyme (ACE) exert synergistic metabolic effects.
   EXPERIMENTAL APPROACH
   Spontaneously hypertensive rats were allowed to choose between palatable chocolate bars and standard chow and were simultaneously treated with the AT(1) blocker telmisartan (8 mg.kg(bw)(-1.)day(-1)), the ACE inhibitor ramipril (4 mg.kg(bw)(-1.)day(-1)) or a combination of the two (8 + 4 mg.kg(bw)(-1.)day(-1)) for 12 weeks.
   KEY RESULTS
   Although food- dependent energy intake was increased by telmisartan and telmisartan + ramipril compared with ramipril or controls, body weight gain, abundance of fat and plasma leptin levels were decreased. Increased insulin levels in response to an oral glucose tolerance test were comparably attenuated by telmisartan and telmisartan + ramipril, but not by ramipril. During an insulin tolerance test, glucose utilization was equally as effectively improved by telmisartan and telmisartan + ramipril. In response to a stress test, ACTH, corticosterone and glucose increased in controls. These stress reactions were attenuated by telmisartan and telmisartan + ramipril.
   CONCLUSIONS AND IMPLICATIONS
   The combination of telmisartan + ramipril was no more efficacious in regulating body weight and glucose homeostasis than telmisartan alone. However, telmisartan was more effective than ramipril in improving metabolic parameters and in reducing body weight. The association between the decrease in stress responses and the diminished glucose levels after stress supports our hypothesis that the ability of telmisartan, as an AT(1) receptor blocker, to alleviate stress reactions may contribute to its hypoglycaemic actions.
C1 [Miesel, Anja; Mueller-Fielitz, Helge; Joehren, Olaf; Raasch, Walter] Univ Lubeck, Inst Expt & Clin Pharmacol & Toxicol, D-23538 Lubeck, Germany.
   [Vogt, Florian M.] Univ Lubeck, Clin Radiol & Nucl Med, D-23538 Lubeck, Germany.
C3 University of Lubeck; University of Lubeck
RP Raasch, W (corresponding author), Univ Lubeck, Inst Expt & Clin Pharmacol & Toxicol, Ratzeburger Allee 160, D-23538 Lubeck, Germany.
EM raasch@medinf.mu-luebeck
RI Raasch, Walter/AAR-1165-2020; Jöhren, Olaf/G-6967-2011; Vogt,
   Florian/C-1705-2012
OI Johren, Olaf/0000-0002-0532-5133; Muller-Fielitz,
   Helge/0000-0003-2815-4426
FU Medical Faculty of the University of Lubeck [P10-2007]; Boehringer
   Ingelheim Pharmaceuticals, Inc. (Ridgefield, CT)
FX This study was supported by a grant (P10-2007) from the Dean of the
   Medical Faculty of the University of Lubeck and by a grant from
   Boehringer Ingelheim Pharmaceuticals, Inc. (Ridgefield, CT). Drugs were
   generous gifts from Boehringer Ingelheim Pharmaceuticals, Inc.
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NR 74
TC 30
Z9 31
U1 0
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0007-1188
EI 1476-5381
J9 BRIT J PHARMACOL
JI Br. J. Pharmacol.
PD APR
PY 2012
VL 165
IS 8
SI SI
BP 2721
EP 2735
DI 10.1111/j.1476-5381.2011.01726.x
PG 15
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 914CB
UT WOS:000301925200028
PM 22014027
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Yagmur, J
   Ermis, N
   Acikgoz, N
   Cansel, M
   Atas, H
   Karakus, Y
   Pekdemir, H
   Ozdemir, R
AF Yagmur, Julide
   Ermis, Necip
   Acikgoz, Nusret
   Cansel, Mehmet
   Atas, Halil
   Karakus, Yasin
   Pekdemir, Hasan
   Ozdemir, Ramazan
TI Elevated serum gamma-glutamyl transferase activity in patients with
   cardiac syndrome X and its relationship with carotid intima media
   thickness
SO ACTA CARDIOLOGICA
LA English
DT Article
DE Gamma-glutamyl transferase; cardiac syndrome X; carotid intima media
   thickness
ID C-REACTIVE PROTEIN; CHEST-PAIN; TRANSPEPTIDASE; ASSOCIATIONS;
   INFLAMMATION; OXIDATION; DISEASE; ANGINA; COHORT
AB Objectives - We aimed to evaluate serum gamma-glutamyl transferase (GGT) activity and its relationship with carotid intima media thickness (CIMT) in patients with cardiac syndrome X (CSX).
   Methods - The study population consisted of 40 patients with CSX, 35 controls and 40 patients with coronary artery disease (CAD). All patients underwent a noninvasive stress test and conventional coronary angiography. Serum GGT and C-reactive protein (CRP) levels were measured and CIMT was assessed in all subjects.
   Results - Serum GGT activity was higher in the CSX and the CAD groups than in the control group (32.6 +/- 16.0 and 30.4 +/- 15.3 U/L, respectively, vs. 17.9 +/- 4.2 U/L; P < 0.001). There was no statistically significant difference in serum GGT activity between the CSX and the CAD groups. When compared to the control group, serum CRP levels were significantly increased in both the CSX and the CAD groups (4.1 +/- 2.0 and 4.7 +/- 2.6 mg/L, respectively, vs. 2.2 +/- 1.8 mg/L; P < 0.001). Patients with CSX and CAD had significantly higher CIMT values than the controls (0.74 +/- 0.17 and 0.94 +/- 0.12 mm, respectively, vs. 0.62 +/- 0.08 mm; P < 0.001). A significant correlation was found between GGT activity and CIMT measurements (r = 0.640, P < 0.001), but serum GGT activity did not correlate with serum CRP levels in patients with CSX (r = 0.277, P > 0.05).
   Conclusions - The present study showed that serum GGT activity in patients with CSX was as high as those in patients with CAD. Increased GGT levels may play a role in the pathogenesis of the microvascular atherosclerotic process of CSX.
C1 [Yagmur, Julide] Inonu Univ, Kardiyoloji Anabilim Dali, Turgut Ozal Tip Merkezi, Arastiima & Uygulama Hastanesi,Tip Fak, Malatya, Turkey.
C3 Inonu University
RP Yagmur, J (corresponding author), Inonu Univ, Kardiyoloji Anabilim Dali, Turgut Ozal Tip Merkezi, Arastiima & Uygulama Hastanesi,Tip Fak, Malatya, Turkey.
RI Akaycan, Jülide/ABI-2397-2020; Pekdemir, Hasan/ABI-6096-2020; Cansel,
   Mehmet/ABI-6324-2020; Ermis, Necip/A-5184-2018
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NR 26
TC 9
Z9 9
U1 0
U2 9
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0001-5385
EI 1784-973X
J9 ACTA CARDIOL
JI Acta Cardiol.
PD OCT
PY 2010
VL 65
IS 5
BP 515
EP 519
DI 10.1080/AC.65.5.2056237
PG 5
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 674AZ
UT WOS:000283707000004
PM 21125972
DA 2025-06-11
ER

PT J
AU Biljak, VR
   Rumora, L
   Cepelak, I
   Pancirov, D
   Popovic-Grle, S
   Soric, J
   Stjepanovic, G
   Grubisic, TZ
AF Biljak, Vanja Radisic
   Rumora, Lada
   Cepelak, Ivana
   Pancirov, Dolores
   Popovic-Grle, Sanja
   Soric, Jasna
   Stjepanovic, Gordana
   Grubisic, Tihana Zanic
TI Gamma-Glutamyltransferase and C-Reactive Protein in Stable Chronic
   Obstructive Pulmonary Disease
SO COLLEGIUM ANTROPOLOGICUM
LA English
DT Article
DE chronic obstructive pulmonary disease; C-reactive protein;
   gamma-glutamyltransferase; smoking; systemic inflammation
ID ARTERY RISK DEVELOPMENT; LUNG-FUNCTION; CARDIOVASCULAR-DISEASE;
   METABOLIC SYNDROME; OXIDATIVE STRESS; INFLAMMATION; ASSOCIATION; COPD;
   GLUTAMYLTRANSFERASE; MARKERS
AB Systemic inflammation and oxidative stress are the most important features of chronic obstructive pulmonary disease (COPD). The presence of oxidative stress in the airways of smokers, the largest population of COPD patients, is a consequence of direct inhalation of cigarette smoke and increased inflammation-related production of reactive oxygen species. On the other hand, oxidative stress appears to be the key component of many processes associated with chronic inflammation. We intend to examine whether serum C-reactive protein (CRP) concentration and gamma-glutamyltransferase (GGT) activity might be used as auxiliary markers in monitoring level of oxidative stress and inflammation in clinically stable COPD. We also investigated influence of cigarette smoking on these two systemic parameters. Catalytic activity of GGT and concentration of CRP were determined in sera of COPD patients (N=109) and in healthy controls (N=51) by using standard spectrophotometric method and immunoturbidimetric method, respectively. Concentration of CRP and activity of GGT were increased in COPD patients, as compared to healthy controls (p<0.05). We found a significant positive correlation between those two parameters in COPD patients(r=0.202, p=0.0371). Our results showed no difference in GGT activity (p=0.606) or CRP concentration (p=0.573) between groups of patients when subdivided according to the severity of the disease. Smoking did not have a significant impact on CRP and GGT values in COPD patients and healthy controls. We showed an increase of serum CRP and GGT values in COPD patients, and we suggest that serum GGT activity might also represent an inflammation/oxidative stress marker. It seems that COPD patients present higher serum CRP and GGT values than healthy subjects independently from their smoking habits.
C1 [Biljak, Vanja Radisic] Univ Zagreb, Merkur Univ Hosp, Univ Dept Med Biochem & Lab Med, Zagreb 10000, Croatia.
   [Rumora, Lada; Cepelak, Ivana; Soric, Jasna; Grubisic, Tihana Zanic] Univ Zagreb, Fac Pharm & Biochem, Dept Med Biochem & Haematol, Zagreb 10000, Croatia.
   [Pancirov, Dolores; Stjepanovic, Gordana] Dr Ivo Pedisic Gen Hosp, Dept Pulmol, Petrinja, Croatia.
   [Popovic-Grle, Sanja] Univ Zagreb, Zagreb Univ Hosp Ctr, Jordanovac Univ Hosp Lung Dis, Sch Med, Zagreb 10000, Croatia.
C3 University of Zagreb; University of Zagreb; University of Zagreb;
   UNIVERSITY ZAGREB HOSPITAL
RP Biljak, VR (corresponding author), Univ Zagreb, Merkur Univ Hosp, Univ Dept Med Biochem & Lab Med, Zajceva 19, Zagreb 10000, Croatia.
EM vanja.radisic@gmail.com
RI Radišić Biljak, Vanja/AGD-6139-2022
OI Radisic Biljak, Vanja/0000-0002-3385-0533; Rumora,
   Lada/0000-0002-5302-3770
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NR 31
TC 14
Z9 17
U1 0
U2 5
PU COLLEGIUM ANTROPOLOGICUM
PI ZAGREB
PA INST ANTHROPOLOGICAL RESEARCH, GAJEVA 32, PO BOX 290, HR-10000 ZAGREB,
   CROATIA
SN 0350-6134
J9 COLLEGIUM ANTROPOL
JI Coll. Anthropol.
PD MAR
PY 2013
VL 37
IS 1
BP 221
EP 227
PG 7
WC Anthropology
WE Social Science Citation Index (SSCI)
SC Anthropology
GA 134HI
UT WOS:000318200600035
PM 23697277
DA 2025-06-11
ER

PT J
AU Tsurugano, S
   Nakao, M
   Takeuchi, T
   Nomura, K
   Yano, E
AF Tsurugano, Shinobu
   Nakao, Mutsuhiro
   Takeuchi, Takeaki
   Nomura, Kyoko
   Yano, Eiji
TI Job Stress Strengthens the Link between Metabolic Risk Factors and Renal
   Dysfunction in Adult Men
SO TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE
LA English
DT Article
DE chronic kidney disease; estimated glomerular filtration rate; job
   strain; metabolic syndrome; renal function
ID CHRONIC KIDNEY-DISEASE; GLOMERULAR-FILTRATION-RATE; PULSE-WAVE VELOCITY;
   MYOCARDIAL-INFARCTION; HEALTH BEHAVIORS; BLOOD-PRESSURE; DECISION
   LATITUDE; JAPANESE VERSION; WHITEHALL-II; POPULATION
AB Chronic kidney disease (CKD) is an important risk factor for cardiovascular disease. The metabolic risk factors obesity, hypertension, diabetes, and dyslipidemia are closely associated with renal dysfunction. As psychosocial stress affects these risk factors, here, we examined relationships between metabolic risk factors and renal function, and their association with job stress. The participants were 1,231 Japanese male office workers attending annual health examinations. The estimated glomerular filtration rate (eGFR) was determined using the equation recommended by the Japanese Society for Nephrology: eGFR (mL/min/1.73 m(2)) = 194x age(-0.287) x Cr-1.094. Job stress was measured using the Job Content Questionnaire based on the job demand-control model. The job strain index equaled the job demand scores divided by the job control scores. The participants were classified into four ordinal groups of job strain index, based on previous studies (i.e., <= 0.4 the lowest, 0.4-0.5 lower, 0.5-0.6 higher, or >= 0.6 the highest). A significant correlation was found between lowered eGFR and each of the metabolic risk factors waist circumference, systolic and diastolic blood pressure, and total cholesterol (p < 0.001). Furthermore, job stress had an interactive effect on the relationships between eGFR and systolic and diastolic blood pressure, and triglycerides, depending on the job strain index (highest vs. lowest) (p < 0.05). The highly stressed workers exhibited a close association of eGFR with metabolic risk factors like hypertension and dyslipidemia. Therefore, intensive management may be important for preventing the progression of renal dysfunction and cardiovascular complications in those experiencing stress.
C1 [Tsurugano, Shinobu] Teikyo Univ, Sch Med, Dept Hyg & Publ Hlth, Itabashi Ku, Tokyo 1738605, Japan.
   [Nakao, Mutsuhiro; Takeuchi, Takeaki; Nomura, Kyoko] Teikyo Univ Hosp, Div Psychosomat Med, Tokyo, Japan.
C3 Teikyo University; Teikyo University
RP Tsurugano, S (corresponding author), Teikyo Univ, Sch Med, Dept Hyg & Publ Hlth, Itabashi Ku, 2-11-1 Kaga, Tokyo 1738605, Japan.
EM turugano-tky@umin.ac.jp
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NR 46
TC 13
Z9 13
U1 0
U2 14
PU TOHOKU UNIV MEDICAL PRESS
PI SENDAI
PA 2-1, SEIRYO-MACHI, AOBA-KU, SENDAI, MIYAGI 980-8575, JAPAN
SN 0040-8727
EI 1349-3329
J9 TOHOKU J EXP MED
JI Tohoku J. Exp. Med.
PD FEB
PY 2012
VL 226
IS 2
BP 101
EP 108
DI 10.1620/tjem.226.101
PG 8
WC Medicine, General & Internal; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine; Research & Experimental Medicine
GA 898SG
UT WOS:000300761500002
PM 22245766
DA 2025-06-11
ER

PT J
AU Han, MS
   Chung, KW
   Cheon, HG
   Dal Rhee, S
   Yoon, CH
   Lee, MK
   Kim, KW
   Lee, MS
AF Han, Myoung Sook
   Chung, Kun Wook
   Cheon, Hyae Gyeong
   Dal Rhee, Sang
   Yoon, Chang-Hwan
   Lee, Moon-Kyu
   Kim, Kwang-Won
   Lee, Myung-Shik
TI Imatinib Mesylate Reduces Endoplasmic Reticulum Stress and Induces
   Remission of Diabetes in db/db Mice
SO DIABETES
LA English
DT Article
ID ABL TYROSINE KINASE; ISLET-CELL-DEATH; INSULIN-RESISTANCE; C-ABL;
   SIGNAL-TRANSDUCTION; ER STRESS; IN-VITRO; PHOSPHORYLATION; ACTIVATION;
   RECEPTOR
AB OBJECTIVE-Imatinib has been reported to induce regression of type 2 diabetes in chronic leukemia patients. However, the mechanism of diabetes amelioration by imatinib is unknown, and it is uncertain whether imatinib has effects on type 2 diabetes itself without other confounding diseases like leukemia. We studied the effect of imatinib on diabetes in db/db mice and investigated possible mechanism's underlying improved glycemic control by imatinib.
   RESEARCH DESIGN AND METHODS-Glucose tolerance and insulin tolerance tests were done after daily intraperitoneal injection of 25 mg/kg imatinib into db/db and C57BL/6 mice for 4 weeks. Insulin signaling and endoplasmic reticulum stress responses were studied by Western blotting. beta-Cell mass and apoptotic beta-cell number were determined by combined terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling (TUNEL) staining and insulin immunohistochemistry. The in vitro effect of imatinib was studied using HepG2 cells.
   RESULTS-Imatinib induced remission of diabetes in db/db mice and amelioration of insulin resistance. Expression of endoplasmic reticulum stress markers in the liver and adipose tissues of db/db mice, such as phospho-PERK, phospho-eIF2 alpha, TRB3, CHOP, and phospho-c-Jun NH2-terminal kinase, was reduced by imatinib. Insulin receptor substrate-1 tyrosine phosphorylation and Akt phosphorylation after insulin administration were improved by imatinib. Serum aminotransferase levels and hepatic triglyceride contents were decreased by imatinib. Pancreatic beta-cell mass was increased by imatinib, accompanied by decreased TUNEL+ beta-cell and increased BrdU(+) beta-cell numbers. Imatinib attenuated endoplasmic reticulum stress in hepatoma cells in vitro.
   CONCLUSIONS-Imatinib ameliorated endoplasmic reticulum stress and induced remission of diabetes in db/db mice. Imatinib, or related compounds could be used as therapeutic agents against type 2 diabetes and metabolic syndrome. Diabetes 58: 329-336, 2009
C1 [Han, Myoung Sook; Chung, Kun Wook; Lee, Moon-Kyu; Kim, Kwang-Won; Lee, Myung-Shik] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Med, Seoul, South Korea.
   [Cheon, Hyae Gyeong; Dal Rhee, Sang] Korea Res Inst Chem Technol, Div Med Sci, Taejon, South Korea.
   [Yoon, Chang-Hwan] Hanyang Univ, Dept Chem, Lab Mol Biochem, Seoul 133791, South Korea.
C3 Sungkyunkwan University (SKKU); Samsung Medical Center; Korea Research
   Institute of Chemical Technology (KRICT); Hanyang University
RP Lee, MS (corresponding author), Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Med, Seoul, South Korea.
EM mslee0923@skku.edu
RI Yoon, Changhwan/AAK-7842-2021; Lee, Myung/C-9606-2011
OI Yoon, Changhwan/0000-0002-8420-9818; Han, Myoung
   Sook/0000-0002-7226-2590
FU Korea Science and Engineering Foundation [R11-2000-080-11003-0];
   Nano/Bio Science Program [2004-00716]; Korean Ministry of Science and
   Technology [FPR08B1-210]
FX M.-S.L. is the recipient of Science Research Center Grant
   R11-2000-080-11003-0 from the Korea Science and Engineering Foundation.
   This work was supported by Nano/Bio Science Program Grant 2004-00716 and
   by the 21C, Frontier Functional Proteomics Project of the Korean
   Ministry of Science and Technology (FPR08B1-210). No potential conflicts
   of interest relevant to this article were reported. We are grateful to
   Drs. E. Buchdunger and S.H. Koo for valuable comments. Parts of this
   study were presented in abstract form at the Keystone Symposia J3, Type
   2 Diabetes and Insulin Resistance, Banff, Alberta, Canada, 20-25 January
   2009.
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NR 45
TC 97
Z9 104
U1 0
U2 13
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0012-1797
EI 1939-327X
J9 DIABETES
JI Diabetes
PD FEB
PY 2009
VL 58
IS 2
BP 329
EP 336
DI 10.2337/db08-0080
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 401GI
UT WOS:000262927500007
PM 19171749
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Liu, XB
   Mameza, MG
   Lee, YS
   Eseonu, CI
   Yu, CR
   Derwent, JJK
   Egwuagu, CE
AF Liu, Xuebin
   Mameza, Marie G.
   Lee, Yun Sang
   Eseonu, Chikezie I.
   Yu, Cheng-Rong
   Derwent, Jennifer J. Kang
   Egwuagu, Charles E.
TI Suppressors of cytokine-signaling proteins induce insulin resistance in
   the retina and promote survival of retinal cells
SO DIABETES
LA English
DT Article
ID EXPERIMENTAL AUTOIMMUNE UVEITIS; DIABETIC-RETINOPATHY; HEPATIC
   STEATOSIS; INTERFERON-GAMMA; IN-VIVO; EXPRESSION; ACTIVATION; RECEPTOR;
   SOCS-3; STAT3
AB OBJECTIVE-Suppressors of cytokine signaling (SOCS) are implicated in the etiology of diabetes, obesity, and metabolic syndrome. Here, we show that some SOCS members are induced, while others are constitutively expressed, in retina and examine whether persistent elevation of SOCS levels in retina by chronic inflammation or cellular stress predisposes to developing insulin resistance in retina, a condition implicated in diabetic retinopathy.
   RESEARCH DESIGN AND METHODS-SOCS-mediated insulin resistance and neuroprotection in retina were investigated in 1) an experimental uveitis model, 2) SOCS1 transgenic rats, 3) insulin-deficient diabetic rats, 4) retinal cells depleted of SOCS6 or overexpressing SOCS1/SOCS3, and 5) oxidative stress and light-induced retinal degeneration models.
   RESULTS-We show that constitutive expression of SOCS6 protein in retinal neurons may improve glucose metabolism, while elevated SOCS1/SOCS3 expression during uveitis induces insulin resistance in neuroretina. SOCS-mediated insulin resistance, as indicated by its inhibition of basally active phosphomositide 3-kinase/AKT signaling in retina, is validated in retina-specific SOCS1 transgenic rats and retinal cells overexpressmig SOCS1/SOCS3. We further show that the SOCS3 level is elevated in retina by oxidative stress, metabolic stress of insulin-deficient diabetes, or light-induced retinal damage and protects ganglion cells from apoptosis, suggesting that upregulation of SOCS3 may be a common physiologic response of neuroretinal cells to cellular stress.
   CONCLUSIONS-Our data suggest two-sided roles of SOCS proteins in retina. Whereas SOCS proteins may improve glucose metabolism, mitigate deleterious effects of inflammation, and promote neuroprotection, persistent SOCS3 expression caused by chronic inflammation or cellular stress can induce insulin resistance and inhibit neurotrophic factors, such as ciliary neurotrophic factor, leukemia inhibitory factor, and insulin, that are essential for retinal cell survival.
C1 [Liu, Xuebin; Mameza, Marie G.; Lee, Yun Sang; Eseonu, Chikezie I.; Yu, Cheng-Rong; Egwuagu, Charles E.] NEI, Mol Immunol Sect, Immunol Lab, NIH, Bethesda, MD 20892 USA.
   [Eseonu, Chikezie I.] Harvard Univ, Dept Biomed Engn, Harvard Coll, Cambridge, MA 02138 USA.
   [Derwent, Jennifer J. Kang] IIT, Pritzker Inst Biomed Sci & Engn, Dept Biomed Engn, Chicago, IL 60616 USA.
C3 National Institutes of Health (NIH) - USA; NIH National Eye Institute
   (NEI); Harvard University; Illinois Institute of Technology
RP Egwuagu, CE (corresponding author), NEI, Mol Immunol Sect, Immunol Lab, NIH, Bldg 10,Rm 10N116,10 Ctr Dr, Bethesda, MD 20892 USA.
EM egwuaguc@nei.nih.gov
OI Yu, Cheng-Rong/0000-0001-7246-0362; Kang-Mieler,
   Jennifer/0000-0002-2844-5066
FU Intramural NIH HHS [Z01 EY000280] Funding Source: Medline
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NR 47
TC 52
Z9 62
U1 0
U2 4
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0012-1797
EI 1939-327X
J9 DIABETES
JI Diabetes
PD JUN
PY 2008
VL 57
IS 6
BP 1651
EP 1658
DI 10.2337/db07-1761
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 311PH
UT WOS:000256611600027
PM 18356406
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Weber-Hamann, B
   Werner, M
   Hentschel, F
   Bindeballe, N
   Lederbogen, F
   Deuschle, M
   Heuser, I
AF Weber-Hamann, B
   Werner, M
   Hentschel, F
   Bindeballe, N
   Lederbogen, F
   Deuschle, M
   Heuser, I
TI Metabolic changes in elderly patients with major depression: Evidence
   for increased accumulation of visceral fat at follow-up
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE major depression; metabolic syndrome; hypercortisolemia; visceral. fat;
   glucose intolerance; follow-up
ID INCREASED INTRAABDOMINAL FAT; PITUITARY-ADRENAL SYSTEM;
   GLUCOSE-TOLERANCE; INSULIN SENSITIVITY; COMPUTED-TOMOGRAPHY;
   ADIPOSE-TISSUE; WOMEN; DEPOSITION; RESISTANCE; DISORDER
AB The accumulation of visceral. fat is promoted by a specific endocrine syndrome, which is similarly found in major depression. The aim of this study was to investigate whether visceral. fat depots increase in depressed patients during a follow-up period explaining the increased risk for cardiovascular disorders.
   Intraabdominal fat was measured in 29 depressed patients and 17 controls by computer tomography at the level of lumbar vertebra 4. In patients fat measurements were done initially during a major depressive episode and again after a follow-up period of 14 months; in controls the mean time interval between measurements was 28 months. In both groups, saliva was taken at 800 h over a period of seven days prior to each CT for the estimation of free cortisol. In patients only, an oral glucose tolerance test was also carried out.
   Compared to controls hyper- and normocortisolemic depressed patients showed a larger accumulation of viscera[ fat mass over time (hypercort.:1 32.0 +/- 45 vs. 144.7 +/- 47 cm(2), p=0.07; normocort.: 115.5 +/- 53 vs. 135.0 +/- 51 cm(2), p=0.002; controls: 130.1 +/- 66 vs. 137.3 +/- 76 cm(2), p=0.4), despite similar weight gain (hypercort.: 2.1 +/- 5 kg, normocort.: 1.7 +/- 5 kg and controls: 2.3 +/- 4 kg). Further, normocortisolemic patients showed a trend for an higher percentile increase in visceral fat accumulation than controls (23.9 +/- 27 vs. 5.8 +/- 28%, p=0.07). At follow-up, free cortisol. concentrations were stilt above normal in patients who had been hypercortisolemic at first assessment (35.0 +/- 8 vs. 28.8 +/- 18 nmol/l, p=0.1). Fasting and 2 h glucose concentrations were higher in hypercortisolemic compared to normocortisolemic patients at the index examination (6.2 +/- 1.1 vs. 5.0 +/- 0.05 mmol/l, p=0.02; 11.5 +/- 2.7 vs. 7.8 +/- 1.9 mmol/l, p=0.01).
   The larger proportion of viscera[ fat accumulation in patients may constitute a link for explaining the increased cardiovascular mortality in patients suffering from major depression. (C) 2005 Elsevier Ltd. All rights reserved.
C1 Cent Inst Mental Hlth, D-68159 Mannheim, Germany.
   Dept Psychiat, D-14050 Berlin, Germany.
C3 Central Institute of Mental Health
RP Cent Inst Mental Hlth, J5, D-68159 Mannheim, Germany.
EM weber@zi-mannheim.de
RI Hentschel, Frank/MZQ-3466-2025; Deuschle, Michael/E-4638-2012
OI Heuser, Isabella/0000-0001-7075-1158
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NR 26
TC 66
Z9 68
U1 1
U2 4
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD APR
PY 2006
VL 31
IS 3
BP 347
EP 354
DI 10.1016/j.psyneuen.2005.08.014
PG 8
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA 024HQ
UT WOS:000236186500010
PM 16213663
DA 2025-06-11
ER

PT J
AU Yagihara, F
   Lucchesi, LM
   D'Almeida, V
   de Mello, MT
   Tufik, S
   Bittencourt, LRA
AF Yagihara, Fabiana
   Lucchesi, Ligia Mendonca
   D'Almeida, Vania
   de Mello, Marco Tulio
   Tufik, Sergio
   Azeredo Bittencourt, Lia Rita
TI Oxidative stress and quality of life in elderly patients with
   obstructive sleep apnea syndrome: are there differences after six months
   of Continuous Positive Airway Pressure treatment?
SO CLINICS
LA English
DT Article
DE Continuous Positive Airway Pressure; Elderly; Obstructive Sleep Apnea
   Syndrome; Oxidative Stress; Quality of Life
ID DAYTIME SLEEPINESS; METABOLIC SYNDROME; RISK-FACTORS; PATHOPHYSIOLOGY;
   POPULATION; PARAMETERS; IMPACT
AB OBJECTIVES: This study evaluated the effect of Continuous Positive Airway Pressure treatment on oxidative stress parameters and the quality of life of elderly patients with obstructive sleep apnea syndrome.
   METHODS: In total, 30 obstructive sleep apnea syndrome patients and 27 subjects without obstructive sleep apnea syndrome were included in this study. Both groups underwent quality of life and oxidative stress evaluations at baseline and after six months. Polysomnography was performed in both groups at baseline and a second time in the obstructive sleep apnea syndrome group after six months of Continuous Positive Airway Pressure treatment. All of the variables were compared between the control and obstructive sleep apnea syndrome groups in this prospective case-control study.
   RESULTS: The baseline concentrations of the antioxidant enzyme catalase were higher in the obstructive sleep apnea syndrome group than the control group. After Continuous Positive Airway Pressure treatment, the obstructive sleep apnea syndrome group exhibited a reduction in the level of oxidative stress, as indicated by a decrease in the level of lipid peroxidation measured by the malondialdehyde (MDA) concentration [pre: 2.7 nmol malondialdehyde/mL (95% 1.6-3.7) vs. post: 1.3 nmol MDA/mL (0.7-1.9), p < 0.01]. Additionally, improvements were observed in two domains covered by the SF-36 questionnaire: functional capacity [pre: 77.4 (69.2-85.5) vs. post: 83.4 (76.9-89.9), p = 0.002] and pain [pre: 65.4 (52.8-78.1) vs. post: 77.8 (67.2-88.3), p = 0.004].
   CONCLUSION: Our study demonstrated that the use of Continuous Positive Airway Pressure to treat obstructive sleep apnea syndrome in elderly patients reduced oxidative stress and improved the quality of life.
C1 [Yagihara, Fabiana; Lucchesi, Ligia Mendonca; D'Almeida, Vania; de Mello, Marco Tulio; Tufik, Sergio; Azeredo Bittencourt, Lia Rita] Univ Fed Sao Paulo UNIFESP, Dept Psicobiol, Sao Paulo, Brazil.
C3 Universidade Federal de Sao Paulo (UNIFESP)
RP Yagihara, F (corresponding author), Univ Fed Sao Paulo UNIFESP, Dept Psicobiol, Sao Paulo, Brazil.
EM lia@psicobio.epm.br
RI Tufik, Sergio/D-7606-2012; D'Almeida, Vania/AAB-7115-2020; Yagihara,
   Fabiana/I-6138-2012; Bittencourt, Lia/C-6551-2012; de Mello, Marco
   Tulio/G-3237-2010
OI Bittencourt, Lia/0000-0001-7738-0927; de Mello, Marco
   Tulio/0000-0003-3896-2208; D'Almeida, Vania/0000-0003-0947-5312
FU Associacao Fundo de Incentivo a Psicofarmacologia (AFIP); Fundacao de
   Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2007/06232-0];
   Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq);
   Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
   [98/14303-3, 07/06232-0] Funding Source: FAPESP
FX This work was supported by grants from the Associacao Fundo de Incentivo
   a Psicofarmacologia (AFIP) and Fundacao de Amparo a Pesquisa do Estado
   de Sao Paulo (FAPESP) (2007/06232-0 to FY and Centro de Pesquisa,
   Inovacao e Difusao [CEPID] no. 98/14303-3 to ST). ST, VD'A, MTMello and
   LRAB received a fellowship from the Conselho Nacional de Desenvolvimento
   Cientifico e Tecnologico (CNPq). The authors would like to thank Laura
   de Siqueira Castro and Altay Lino de Souza from the Departamento de
   Psicobiologia/Universidade Federal de Sao Paulo for their valuable
   suggestions and help with the statistical analysis.
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NR 51
TC 18
Z9 20
U1 1
U2 10
PU HOSPITAL CLINICAS, UNIV SAO PAULO
PI SAO PAULO
PA FAC MEDICINA, UNIV SAO PAULO, SAO PAULO, SP 00000, BRAZIL
SN 1807-5932
EI 1980-5322
J9 CLINICS
JI Clinics
PY 2012
VL 67
IS 6
BP 565
EP 571
DI 10.6061/clinics/2012(06)04
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 968LK
UT WOS:000305982700004
PM 22760893
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Khoja, A
   Andraweera, PH
   Lassi, ZS
   Ali, A
   Zheng, MY
   Pathirana, MM
   Aldridge, E
   Wittwer, MR
   Chaudhuri, DD
   Tavella, R
   Arstall, MA
AF Khoja, Adeel
   Andraweera, Prabha H.
   Lassi, Zohra S.
   Ali, Anna
   Zheng, Mingyue
   Pathirana, Maleesa M.
   Aldridge, Emily
   Wittwer, Melanie R.
   Chaudhuri, Debajyoti D.
   Tavella, Rosanna
   Arstall, Margaret A.
TI Risk Factors for Premature Coronary Heart Disease in Women Compared to
   Men: Systematic Review and Meta-Analysis
SO JOURNAL OF WOMENS HEALTH
LA English
DT Article
DE premature coronary heart disease; risk factors; women; men; sex
   differences
ID ACUTE MYOCARDIAL-INFARCTION; ARTERY-DISEASE; METABOLIC SYNDROME;
   SEX-DIFFERENCES; GENDER-DIFFERENCES; YOUNG-PATIENTS; LIPOPROTEIN(A)
   INTERACTIONS; HIGH PREVALENCE; AGE; HOSPITALIZATION
AB Background and Aim: We aimed to systematically examine literature on the prevalence of known modifiable and nonmodifiable risk factors for premature coronary heart disease (PCHD) in women compared with men.Materials and Methods: PubMed, CINAHL, Embase, and Web of Science databases were searched. Review protocol is registered in PROSPERO (CRD42020173216). Quality was assessed using the National Heart, Lung, and Blood Institute tool. Review Manager 5.3 was used for meta-analysis. Effect sizes were expressed as odds ratio (OR) and mean differences/standardized mean differences (SMD) with 95% confidence intervals (CIs) for categorical and continuous variables.Results: In this PCHD cohort (age <65 years), the mean age of presentation in women was 3 years older than men. Women had higher total cholesterol (SMD 0.11; 95% CI 0.00 to 0.23) and higher high-density lipoprotein cholesterol (SMD 0.49; 95% CI 0.29 to 0.69). Women were more likely to have hypertension (OR 1.51, 95% CI 1.42 to 1.60), diabetes mellitus (OR 1.78, 95% CI 1.55 to 2.04), obesity (OR 1.33, 95% CI 1.24 to 1.42), metabolic syndrome (OR 3.73, 95% CI 1.60 to 8.69), stroke (OR 1.63, 95% CI 1.51 to 1.77), peripheral vascular disorder (OR 1.67, 95% CI 1.43 to 1.96), and depression (OR 2.29, 95% CI 1.96 to 2.67). Women were less likely to be smokers (OR 0.60, 95% CI 0.55 to 0.66), have reported alcohol intake (OR 0.36, 95% CI 0.33 to 0.40), and reported use of illicit drug (OR 0.32, 95% CI 0.16 to 0.62).Conclusions: Risk factor profile in PCHD has a clear sex difference that supports early, aggressive, holistic, but sex-specific, approach to prevention.
C1 [Khoja, Adeel; Andraweera, Prabha H.; Lassi, Zohra S.; Ali, Anna; Zheng, Mingyue; Pathirana, Maleesa M.; Aldridge, Emily; Wittwer, Melanie R.; Chaudhuri, Debajyoti D.; Tavella, Rosanna] Univ Adelaide, Fac Hlth & Med Sci, Adelaide Med Sch, Adelaide, SA, Australia.
   [Khoja, Adeel; Andraweera, Prabha H.; Lassi, Zohra S.; Ali, Anna; Pathirana, Maleesa M.; Aldridge, Emily] Univ Adelaide, Robinson Res Inst, Adelaide, SA, Australia.
   [Khoja, Adeel; Andraweera, Prabha H.; Pathirana, Maleesa M.; Aldridge, Emily; Wittwer, Melanie R.; Chaudhuri, Debajyoti D.; Arstall, Margaret A.] Northern Adelaide Local Hlth Network, Cardiol Unit, Adelaide, SA, Australia.
   [Zheng, Mingyue] Chengdu Univ Tradit Chinese Med, Sch Hlth & Rehabil, Chengdu, Peoples R China.
   [Tavella, Rosanna] Queen Elizabeth Hosp, Basil Hetzel Inst Translat Hlth Res, Dept Cardiol, Woodville South, SA, Australia.
   [Arstall, Margaret A.] Univ Adelaide, Fac Hlth Sci, Med Specialties, Adelaide, SA, Australia.
   [Arstall, Margaret A.] Univ Adelaide, Fac Hlth Sci, Med Specialties, Adelaide, SA 5000, Australia.
   [Khoja, Adeel] Univ Adelaide, Fac Hlth & Med Sci, Adelaide Med Sch, Adelaide, SA 5000, Australia.
C3 University of Adelaide; University of Adelaide; Robinson Research
   Institute; Chengdu University of Traditional Chinese Medicine;
   University of Adelaide; University of Adelaide; University of Adelaide
RP Arstall, MA (corresponding author), Univ Adelaide, Fac Hlth Sci, Med Specialties, Adelaide, SA 5000, Australia.; Khoja, A (corresponding author), Univ Adelaide, Fac Hlth & Med Sci, Adelaide Med Sch, Adelaide, SA 5000, Australia.
EM adeel.khoja@adelaide.edu.au; margaret.arstall@sa.gov.au
RI , Mingyue Zheng/AAQ-4463-2021; Tavella, Rosanna/C-1836-2017; Khoja,
   Adeel/ABA-8794-2020
OI Arstall, Margaret/0000-0003-0760-6382; Khoja, Adeel/0000-0003-1513-408X
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NR 87
TC 5
Z9 5
U1 0
U2 8
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-9996
EI 1931-843X
J9 J WOMENS HEALTH
JI J. Womens Health
PD SEP 1
PY 2023
VL 32
IS 9
BP 908
EP 920
DI 10.1089/jwh.2022.0517
EA MAY 2023
PG 13
WC Public, Environmental & Occupational Health; Medicine, General &
   Internal; Obstetrics & Gynecology; Women's Studies
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; General & Internal
   Medicine; Obstetrics & Gynecology; Women's Studies
GA R2TT4
UT WOS:000986982700001
PM 37184900
DA 2025-06-11
ER

PT J
AU Yan, F
   Huang, L
   Jiang, YX
   Jiang, CY
   Huang, Y
   He, J
   Wang, J
   Hu, GH
   Zou, LJ
   Xu, Q
   Zhang, XK
   Gao, YF
AF Yan, Fen
   Huang, Lei
   Jiang, Yuanxiao
   Jiang, Canyu
   Huang, Ya
   He, Jie
   Wang, Jie
   Hu, Gonghua
   Zou, Lijun
   Xu, Qi
   Zhang, Xiaokang
   Gao, Yanfang
TI Impact of multi-metal exposure on blood pressure: a mediation analysis
   through oxidative stress markers in China's Southern Jiangxi Province
SO BMC PUBLIC HEALTH
LA English
DT Article
DE Urinary metals; Blood pressure; Oxidative stress; BKMR; Mediation
   analysis
ID URINARY HEAVY-METAL; METABOLIC SYNDROME; ALUMINUM EXPOSURE; US NHANES;
   HYPERTENSION; PHTHALATE; CHROMIUM; SELENIUM; HEALTH; RISK
AB Hypertension is a prevalent condition that contributes significantly to the global disease burden. Recent research endeavors have been investigating the potential causal link between metal exposure and the development of hypertension, yet consensus remains elusive. Nevertheless, studies examining the interplay among metal exposure, hypertension, and oxidative stress are relatively limited. This study utilized data from a cross-sectional survey conducted in southern Jiangxi Province, China. We evaluated urinary concentrations of 19 metals, including aluminum and manganese, in conjunction with measurements of systolic and diastolic blood pressures, as well as three oxidative stress biomarkers: glutathione peroxidase (GSH), superoxide dismutase (SOD), and malondialdehyde (MDA). In the monometallic model, chromium, iron, manganese, and molybdenum exhibited positive correlations with blood pressure. These findings were consistent in the mixed exposure model. Conversely, all the aforementioned metals exhibited a negative correlation with GSH and SOD, while demonstrating a positive correlation with MDA. Mediation effect analysis revealed that GSH and SOD mediated the relationships between urinary concentrations of aluminum, iron, manganese, and antimony and blood pressure. In contrast, MDA mediated the associations between urinary silver and antimony and blood pressure. Furthermore, GSH and SOD were identified as mediators in part of the relationship between mixed metal exposure and blood pressure, with mediation rates of 19.09% for GSH and 27.36% for SOD. The results of this study suggest that exposure to both individual and combined metals effects blood pressure levels, which are further associated with changes in oxidative stress levels. Moreover, oxidative stress levels may modulate the changes in blood pressure related to metal exposure, providing a basis for further investigation into the health risks associated with these metal exposures.
C1 [Yan, Fen; Huang, Lei; Jiang, Yuanxiao; Jiang, Canyu; Huang, Ya; He, Jie; Wang, Jie; Hu, Gonghua; Zou, Lijun; Xu, Qi; Zhang, Xiaokang; Gao, Yanfang] Gannan Med Univ, Sch Publ Hlth & Hlth Management, Ganzhou, Peoples R China.
   [Yan, Fen; Huang, Lei; Jiang, Yuanxiao; Jiang, Canyu; Huang, Ya; He, Jie; Wang, Jie; Hu, Gonghua; Zou, Lijun; Xu, Qi; Zhang, Xiaokang; Gao, Yanfang] Gannan Med Univ, Key Lab Prevent & Treatment Cardiovasc & Cerebrova, Minist Educ, Ganzhou, Peoples R China.
C3 Gannan Medical University; Gannan Medical University; Ministry of
   Education - China
RP Zhang, XK; Gao, YF (corresponding author), Gannan Med Univ, Sch Publ Hlth & Hlth Management, Ganzhou, Peoples R China.; Zhang, XK; Gao, YF (corresponding author), Gannan Med Univ, Key Lab Prevent & Treatment Cardiovasc & Cerebrova, Minist Educ, Ganzhou, Peoples R China.
EM Zhangxiaokaju@163.com; gaoyanfang1201@163.com
RI fang, gao/GLU-2575-2022
FU National Natural Science Foundation of China [81903364]; National
   Natural Science Foundation of Jiangxi Province [20242BAB25551]; Key
   science and technology project of Ganzhou Science and Technology Bureau
   [GZ2024YL015]
FX This project was supported by the National Natural Science Foundation of
   China (No.81903364); the National Natural Science Foundation of Jiangxi
   Province (20242BAB25551), the Key science and technology project of
   Ganzhou Science and Technology Bureau (GZ2024YL015).
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JI BMC Public Health
PD MAY 30
PY 2025
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DA 2025-06-11
ER

PT J
AU Saban, KL
   Joyce, C
   Nyembwe, A
   Janusek, L
   Tell, D
   de la Pena, P
   Motley, D
   Shawahin, L
   Prescott, L
   Potts-Thompson, S
   Taylor, JY
AF Saban, Karen L.
   Joyce, Cara
   Nyembwe, Alexandria
   Janusek, Linda
   Tell, Dina
   de la Pena, Paula
   Motley, Darnell
   Shawahin, Lamise
   Prescott, Laura
   Potts-Thompson, Stephanie
   Taylor, Jacquelyn Y.
TI The Effectiveness of a Race-Based Stress Reduction Intervention on
   Improving Stress-Related Symptoms and Inflammation in African American
   Women at Risk for Cardiometabolic Disease: Protocol for Recruitment and
   Intervention fora Randomized Controlled Trial
SO JMIR RESEARCH PROTOCOLS
LA English
DT Article
DE cardiometabolic disease; stress; Resilience; Stress; and Ethnicity; RiSE
   intervention; health of minoritized groups
ID RACIAL-DISCRIMINATION; METABOLIC SYNDROME; DEPRESSIVE SYMPTOMS;
   PERCEIVED DISCRIMINATION; PSYCHOMETRIC PROPERTIES; COPING STRATEGIES;
   DNA METHYLATION; ETHNIC-IDENTITY; BLOOD-PRESSURE; HEALTH
AB Background: In recent years, the prevalence of cardiometabolic disease (CMD) in African American women has risen; the risk also increases with age, in comparison to men. Evidence demonstrates that stressful life events, including experiences of racism and perceived discrimination, contribute substantially to inflammatory diseases, such as CMD. Despite this evidence, few evidence-based interventions are available to assist individuals from minoritized communities in coping with the chronic stress related to their racial or ethnic identity. Objective: Our proposed randomized controlled trial will test a novel, race-based intervention tailored to African American women, called Resilience, Stress, and Ethnicity (RiSE). Methods: In this randomized controlled trial, we will randomize participants 1:1 to the 8-week, group-based RiSE program (intervention) or a health education program (active control group). Both programs will consist of synchronous classes on Zoom and will be led by experts. The primary end point will be stress at 6 months after the intervention, and the efficacy of RiSE will beevaluated for improving stress-related symptoms (current perceived stress, depressivesymptoms, fatigue, and sleep disturbance), improving coping strategies, and reducing inflammatory burden in African American women at risk for CMD. Validated survey measures and inflammatory biomarkers will be assessed at baseline, midintervention, intervention completion, and 6 months after the intervention, and differences over time by intervention will be evaluated using mixed effects models. Results: This study was funded by the National Institute on Aging on March 30, 2023, with recruitment and enrollment beginning in October 2023. The study is underway, with 120 participants enrolled as of March 2025. Conclusions:This study will be one of the first to examine a race-based stress reduction intervention in African American women and has the potential to improve the health of minoritized groups faced with chronic stress associated with experiencing racism and discrimination. We anticipate that RiSE will reduce stress-related symptoms, enhance adaptive coping, and reduce inflammation. Trial Registration: ClinicalTrials.gov NCT05902741; https://www.clinicaltrials.gov/study/NCT05902741
C1 [Saban, Karen L.; Janusek, Linda; Tell, Dina; de la Pena, Paula] Loyola Univ Chicago, Marcella Niehoff Sch Nursing, Ctr Translat Res & Educ, 2160 S First Ave, Maywood, IL 60153 USA.
   [Joyce, Cara] Loyola Univ Chicago, Parkinson Sch Hlth Sci & Publ Hlth, Maywood, IL USA.
   [Nyembwe, Alexandria] Univ Calif Irvine, Irvine, CA USA.
   [Motley, Darnell] Univ Chicago, Dept Med, Chicago, IL USA.
   [Shawahin, Lamise] Governors State Univ, Coll Educ & Human Dev, University Pk, IL USA.
   [Prescott, Laura; Potts-Thompson, Stephanie; Taylor, Jacquelyn Y.] Columbia Univ, Sch Nursing, Ctr Res People Color, New York, NY USA.
C3 Loyola University Chicago; Loyola University Chicago; University of
   California System; University of California Irvine; University of
   Chicago; Governors State University; Columbia University
RP Saban, KL (corresponding author), Loyola Univ Chicago, Marcella Niehoff Sch Nursing, Ctr Translat Res & Educ, 2160 S First Ave, Maywood, IL 60153 USA.
EM Ksaban@luc.edu
RI Saban, Karen/H-4837-2011; Joyce, Cara/Z-2075-2018
FU National Institute on Aging [1R01AG081251-01]
FX The authors thank the Resilience, Stress, and Ethnicity (RiSE) study
   participants, the research team members, and partnering agencies. The
   research is funded by the National Institute on Aging (1R01AG081251-01)
   .
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DI 10.2196/65649
PG 20
WC Health Care Sciences & Services; Public, Environmental & Occupational
   Health
WE Emerging Sources Citation Index (ESCI)
SC Health Care Sciences & Services; Public, Environmental & Occupational
   Health
GA 2GQ1S
UT WOS:001482189700001
PM 40250840
OA gold
DA 2025-06-11
ER

PT J
AU Cha, HY
   Yang, SJ
   Kim, SW
AF Cha, Hee Yun
   Yang, Soo Jin
   Kim, Sung-Wan
TI Higher Dietary Inflammation in Patients with Schizophrenia: A
   Case-Control Study in Korea
SO NUTRIENTS
LA English
DT Article
DE dietary inflammation; folate; niacin; schizophrenia; vitamin C
ID METABOLIC SYNDROME; BIPOLAR DISORDER; VITAMIN-D; RISK; INDEX; DOPAMINE;
   METAANALYSIS; 1ST-EPISODE; PREVENTION; DEPRESSION
AB Inflammation is a risk factor for the onset and progression of schizophrenia, and dietary factors are related to chronic inflammation. We investigated whether the dietary inflammatory index (DII) is associated with schizophrenia in the Korean population. Of the 256 subjects who responded to the questionnaire, 184 subjects (117 controls; 67 individuals with schizophrenia) were included in this case-control study. A semi-quantitative food frequency questionnaire was used to evaluate the dietary intakes of the study participants. The energy-adjusted DII (E-DII) was used to assess the inflammatory potential of the participants' diets. Dietary intakes of vitamin C, niacin, and folate were significantly reduced in the patients with schizophrenia. The patients with schizophrenia had higher E-DII scores than the controls (p = 0.011). E-DII was positively associated with schizophrenia (odds ratio = 1.254, p = 0.010). The additional analysis confirmed that E-DII was significantly associated with schizophrenia, especially in the third tertile group of E-DII scores (odds ratio = 2.731, p = 0.016). Our findings suggest that patients with schizophrenia have more pro-inflammatory diets.
C1 [Cha, Hee Yun; Yang, Soo Jin] Seoul Womens Univ, Dept Food & Nutr, Seoul 01797, South Korea.
   [Kim, Sung-Wan] Gwang Ju Buk Gu Community Mental Hlth Ctr, Gwangju 61261, South Korea.
   [Kim, Sung-Wan] Chonnam Natl Univ, Med Sch, Dept Psychiat, Gwangju 61469, South Korea.
C3 Seoul Women's University; Chonnam National University
RP Yang, SJ (corresponding author), Seoul Womens Univ, Dept Food & Nutr, Seoul 01797, South Korea.; Kim, SW (corresponding author), Gwang Ju Buk Gu Community Mental Hlth Ctr, Gwangju 61261, South Korea.; Kim, SW (corresponding author), Chonnam Natl Univ, Med Sch, Dept Psychiat, Gwangju 61469, South Korea.
EM chaheey@naver.com; sjyang89@swu.ac.kr; swkim@chonnam.ac.kr
OI Kim, Sung-Wan/0000-0002-6739-2163; Yang, Soo Jin/0000-0001-7892-7648
FU Basic Science Research Program through the National Research Foundation
   of Korea [NRF-2017R1A2B4010830, NRF2020R1F1A1065326]; Seoul Women's
   University [2021-0133]
FX This research was supported by research grants from Basic Science
   Research Program through the National Research Foundation of Korea
   (NRF-2017R1A2B4010830 (S.-W.K.) and NRF2020R1F1A1065326 (S.J.Y.)) and
   Seoul Women's University (2021-0133) (S.J.Y.).
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NR 55
TC 5
Z9 6
U1 1
U2 12
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JUN
PY 2021
VL 13
IS 6
AR 2033
DI 10.3390/nu13062033
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nutrition & Dietetics
GA SY8QQ
UT WOS:000666146000001
PM 34199231
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Kim, JW
   Kim, DH
   Roh, YK
   Ju, SY
   Nam, HY
   Nam, GE
   Kim, DW
   Lee, SH
   Lee, CW
   Han, K
   Park, YG
AF Kim, Jae-Woo
   Kim, Do Hoon
   Roh, Yong Kyun
   Ju, Sang Yhun
   Nam, Hyo-Yun
   Nam, Ga-Eun
   Kim, Dong-Won
   Lee, Seung-Hyun
   Lee, Chung-Woo
   Han, Kyungdo
   Park, Yong-Gyu
TI Serum Ferritin Levels Are Positively Associated With Metabolically Obese
   Normal Weight A Nationwide Population-Based Study
SO MEDICINE
LA English
DT Article
ID NUTRITION EXAMINATION SURVEY; INSULIN-RESISTANCE SYNDROME; BODY-MASS
   INDEX; CARDIOVASCULAR-DISEASE; OXIDATIVE STRESS; IRON OVERLOAD; RISK;
   HEALTHY; MEN; HEMOCHROMATOSIS
AB The purpose of this study was to examine the relationship between serum ferritin levels and metabolically obese normal weight (MONW) and to determine the appropriate cut-off value of serum ferritin for the prediction of clinical metabolic status in nonobese Korean adults. Data from 9411 participants in the fourth (2008) and fifth (2010) annual Korea National Health and Nutrition Examination Surveys were used in this study. MONW was determined by combining National Cholesterol Education Program Adult Treatment Panel III criteria, Wildman criteria, and homeostatic model assessment criteria for metabolic healthy obesity. The mean serum ferritin level was 103.5 +/- 1.2 ng/mL in men and 45.5 +/- 0.6 ng/mL in women. The estimated cutoff value of serum ferritin for the prediction of MONW was 127.03 ng/mL in men and 46.87 ng/mL in women. Both men and women who had higher serum ferritin levels than the cutoff value had a higher prevalence of MONW than those individuals who had lower serum ferritin levels than the cutoff value. In the final multivariable adjusted logistic regression model, the odds ratio (95% confidence interval) of MONW in the subjects who had higher serum ferritin levels than the cutoff value was 1.631 (1.312-2.028) in men and 1.298 (1-1.685) in women. In this study, serum ferritin levels were positively associated with MONW, and those subjects who had higher serum ferritin levels than the cutoff value had a higher prevalence and a higher adjusted odds ratio for MONW despite being nonobese.
C1 [Kim, Jae-Woo; Kim, Do Hoon; Nam, Hyo-Yun; Nam, Ga-Eun; Kim, Dong-Won; Lee, Seung-Hyun; Lee, Chung-Woo] Korea Univ, Coll Med, Dept Family Med, Seoul 136705, South Korea.
   [Roh, Yong Kyun] Hallym Univ, Dept Family Med, Coll Med, Chunchon, South Korea.
   [Ju, Sang Yhun] Catholic Univ Korea, Dept Family Med, Coll Med, Seoul, South Korea.
   [Han, Kyungdo; Park, Yong-Gyu] Catholic Univ Korea, Coll Med, Dept Biostat, Seoul, South Korea.
C3 Korea University; Korea University Medicine (KU Medicine); Hallym
   University; Catholic University of Korea; Catholic University of Korea
RP Kim, DH (corresponding author), Korea Univ, Coll Med, Korea Univ Ansan Hosp, Dept Family Med, 516,Gojan1 Dong, Ansan 425707, Gyeonggi Do, South Korea.
EM kmcfm@hanmail.net; rohyk@hallym.ac.kr
RI Ju, Sang/Q-2946-2019; KIM, DONG WON/AFL-8454-2022; Nam, Ga
   Eun/AAU-6055-2020
OI Park, Yong Gyu/0000-0002-8721-3230; Nam, Ga Eun/0000-0002-6739-9904;
   Kim, Do Hoon/0000-0001-7421-4501; Ju, Sang Yhun/0000-0002-0553-7128
CR Badoud F, 2015, FASEB J, V29, P748, DOI 10.1096/fj.14-263913
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NR 25
TC 17
Z9 21
U1 0
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD DEC
PY 2015
VL 94
IS 52
AR e2335
DI 10.1097/MD.0000000000002335
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA DD3XM
UT WOS:000369856700019
PM 26717370
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Soltysik, BK
   Karolczak, K
   Kostka, T
   Stephenson, SS
   Watala, C
   Kostka, J
AF Soltysik, Bartlomiej K.
   Karolczak, Kamil
   Kostka, Tomasz
   Stephenson, Serena S.
   Watala, Cezary
   Kostka, Joanna
TI Contribution of Physical Activity to the Oxidative and Antioxidant
   Potential in 60-65-Year-Old Seniors
SO ANTIOXIDANTS
LA English
DT Article
DE lipid peroxides; free thiol groups; free amino groups; superoxide;
   antioxidant status; physical activity; elderly
ID HYDROGEN-PEROXIDE; PLATELET-AGGREGATION; METABOLIC SYNDROME;
   OLDER-ADULTS; STRESS; EXERCISE; REDOX; MARKERS; PLASMA; HOMOCYSTEINE
AB Both acute exercise and regular physical activity (PA) are directly related to the redox system. However, at present, there are data suggesting both positive and negative relationships between the PA and oxidation. In addition, there is a limited number of publications differentiating the relationships between PA and numerous markers of plasma and platelets targets for the oxidative stress. In this study, in a population of 300 participants from central Poland (covering the age range between 60 and 65 years), PA was assessed as regards energy expenditure (PA-EE) and health-related behaviors (PA-HRB). Total antioxidant potential (TAS), total oxidative stress (TOS) and several other markers of an oxidative stress, monitored in platelet and plasma lipids and proteins, were then determined. The association of PA with oxidative stress was determined taking into the account basic confounders, such as age, sex and the set of the relevant cardiometabolic factors. In simple correlations, platelet lipid peroxides, free thiol and amino groups of platelet proteins, as well as the generation of superoxide anion radical, were inversely related with PA-EE. In multivariate analyses, apart from other cardiometabolic factors, a significant positive impact of PA-HRB was revealed for TOS (inverse relationship), while in the case of PA-EE, the effect was found to be positive (inverse association) for lipid peroxides and superoxide anion but negative (lower concentration) for free thiol and free amino groups in platelets proteins. Therefore, the impact of PA may be different on oxidative stress markers in platelets as compared to plasma proteins and also dissimilar on platelet lipids and proteins. These associations are more visible for platelets than plasma markers. For lipid oxidation, PA seems to have protective effect. In the case of platelets proteins, PA tends to act as pro-oxidative factor.
C1 [Soltysik, Bartlomiej K.; Kostka, Tomasz; Stephenson, Serena S.] Med Univ Lodz, Dept Geriatr, Haller Sq 1, PL-90419 Lodz, Poland.
   [Karolczak, Kamil; Watala, Cezary] Med Univ Lodz, Dept Hemostat Disorders, Mazowiecka St 6-8, PL-92215 Lodz, Poland.
   [Kostka, Joanna] Med Univ Lodz, Dept Gerontol, Milionowa St 14, PL-93113 Lodz, Poland.
C3 Medical University Lodz; Medical University Lodz; Medical University
   Lodz
RP Soltysik, BK (corresponding author), Med Univ Lodz, Dept Geriatr, Haller Sq 1, PL-90419 Lodz, Poland.
EM bartlomiej.soltysik@umed.lodz.pl
RI Watala, Cezary/ABF-4863-2020; Stephenson, Serena
   Schecaniah/HZI-2334-2023; Kostka, Joanna/S-9965-2016; Karolczak,
   Kamil/HDM-6855-2022; Soltysik, Bartlomiej K./S-9839-2016
OI kostka, joanna/0000-0002-6256-1669; stephenson, serena
   schecaniah/0000-0001-5400-4646; Soltysik, Bartlomiej
   K./0000-0002-1382-3757; Kostka, Tomasz/0000-0003-0437-650X
FU Central Institute for Labour Protection-National Research Institute
   project [KBNSR/N/I/427/2014]; Medical University of Lodz, Poland
   [503/6-020-01/503-61-001, 503/6-077-01/503-61-001]
FX The authors were partly supported by the Central Institute for Labour
   Protection-National Research Institute project (KBNSR/N/I/427/2014) and
   received grants founded by Medical University of Lodz, Poland
   (503/6-020-01/503-61-001 and 503/6-077-01/503-61-001).
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NR 81
TC 1
Z9 1
U1 0
U2 3
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD JUN
PY 2023
VL 12
IS 6
AR 1200
DI 10.3390/antiox12061200
PG 15
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA K5NB1
UT WOS:001016893900001
PM 37371930
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Valenta, I
   Dilsizian, V
   Quercioli, A
   Jüngling, FD
   Ambrosio, G
   Wahl, R
   Schindler, TH
AF Valenta, Ines
   Dilsizian, Vasken
   Quercioli, Alessandra
   Juengling, Freimut D.
   Ambrosio, Giuseppe
   Wahl, Richard
   Schindler, Thomas H.
TI Impact of Obesity and Bariatric Surgery on Metabolism and Coronary
   Circulatory Function
SO CURRENT CARDIOLOGY REPORTS
LA English
DT Article
DE Adipocytokine; Adiponectin; Bariatric surgery; Blood flow; Circulation;
   Coronary artery disease; Coronary circulatory function; Cardiovascular
   risk; Endocannabinoids Endothelium; Leptin; Obesity; PET/CT;
   Vasoreactivity; Myocardial flow reserve; Metabolism
ID MYOCARDIAL TRIGLYCERIDE CONTENT; POSITRON-EMISSION-TOMOGRAPHY;
   CARDIOVASCULAR RISK-FACTORS; EPICARDIAL ADIPOSE-TISSUE;
   INSULIN-RESISTANCE; VISCERAL OBESITY; FLOW RESERVE; GLUCOSE-TOLERANCE;
   ABDOMINAL OBESITY; ARTERY-DISEASE
AB Increases in intra-abdominal visceral adipose tissue have been widely appreciated as a risk factor for metabolic disorders such as dyslipidemia, hypertension, insulin resistance, and type 2 diabetes, whereas this is not the case for peripheral or subcutaneous obesity. While the underlying mechanisms that contribute to these differences in adipose tissue activity remain uncertain, increases in visceral fat commonly induce metabolic dysregulation, in part because of increased venous effluent of fatty acids and/or adipokines/cytokines to the liver. Increased body weight, paralleled by an increase in plasma markers of the insulin-resistance syndrome and chronic inflammation, is independently associated with coronary circulatory dysfunction. Recent data suggest that plasma proteins originating from the adipose tissue, such as endocannabinoids (EC), leptin, and adiponectin (termed adipocytes) play a central role in the regulation and control of coronary circulatory function in obesity. Positron emission tomography (PET) in concert with tracer kinetic modeling is a well established technique for quantifying regional myocardial blood flow at rest and in response to various forms of vasomotor stress. Myocardial flow reserve assessed by PET provides a noninvasive surrogate of coronary circulatory function. PET also enables the monitoring and characterization of coronary circulatory function in response to gastric bypass-induced weight loss in initially morbidly obese individuals, to medication and/or behavioral interventions related to weight, diet, and physical activity. Whether the observed improvement in coronary circulatory dysfunction via weight loss may translate to diminution in cardiovascular events awaits clinical confirmation.
C1 [Valenta, Ines; Wahl, Richard; Schindler, Thomas H.] Johns Hopkins Univ, Dept Radiol, Div Nucl Med, Baltimore, MD 21287 USA.
   [Dilsizian, Vasken] Univ Maryland, Sch Med, Dept Diagnost Radiol & Nucl Med, Baltimore, MD 21201 USA.
   [Quercioli, Alessandra] Univ Hosp Geneva, Dept Med Specialties, Div Cardiol, Geneva, Switzerland.
   [Juengling, Freimut D.] Univ Basel, St Claraspital, Basel, Switzerland.
   [Ambrosio, Giuseppe] Univ Perugia, Sch Med, Div Cardiol, I-06100 Perugia, Italy.
   [Schindler, Thomas H.] Johns Hopkins Univ, Dept Radiol & Radiol Sci SOM, Div Nucl Med, Baltimore, MD 21287 USA.
C3 Johns Hopkins University; University System of Maryland; University of
   Maryland Baltimore; University of Geneva; University of Basel;
   University of Perugia; Johns Hopkins University
RP Schindler, TH (corresponding author), Johns Hopkins Univ, Dept Radiol & Radiol Sci SOM, Div Nucl Med, JHOC 3225,601 N Caroline St, Baltimore, MD 21287 USA.
EM Thomas.h.schindler@gmail.com
RI Ambrosio, Giuseppe/JUV-2507-2023; Juengling, Freimut/L-8071-2016
OI Juengling, Freimut/0000-0002-2538-3074; Schindler, Thomas
   Hellmut/0000-0002-2141-7716; WAHL, RICHARD L./0000-0002-7306-2590;
   giuseppe, ambrosio/0000-0002-9677-980X
FU Swiss National Science Foundation (SNF) [3200B0-122237]
FX This work was supported by Research Grant 3200B0-122237 of the Swiss
   National Science Foundation (SNF), with contributions of the Clinical
   Research Center, University Hospital and Faculty of Medicine, Geneva,
   and the Louis-Jeantet Foundation, Gustave and Simone Prevot, and Swiss
   Heart Foundation, Switzerland.
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NR 47
TC 14
Z9 17
U1 0
U2 11
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1523-3782
EI 1534-3170
J9 CURR CARDIOL REP
JI Curr. Cardiol. Rep.
PD JAN
PY 2014
VL 16
IS 1
AR 433
DI 10.1007/s11886-013-0433-8
PG 9
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA AT6ZA
UT WOS:000345084300005
PM 24281976
DA 2025-06-11
ER

PT J
AU Rajpathak, SN
   Wylie-Rosett, J
   Gunter, MJ
   Negassa, A
   Kabat, GC
   Rohan, TE
   Crandall, J
AF Rajpathak, S. N.
   Wylie-Rosett, J.
   Gunter, M. J.
   Negassa, A.
   Kabat, G. C.
   Rohan, T. E.
   Crandall, J.
CA DPP Res Grp
TI Biomarkers of body iron stores and risk of developing type 2 diabetes
SO DIABETES OBESITY & METABOLISM
LA English
DT Article
DE ferritin; transferrin receptors; type 2 diabetes
ID SOLUBLE TRANSFERRIN RECEPTOR; SERUM FERRITIN CONCENTRATIONS;
   INSULIN-RESISTANCE SYNDROME; IDIOPATHIC HEMOCHROMATOSIS; CLINICAL
   UTILITY; PLASMA FERRITIN; CANCER-RISK; OBESE WOMEN; MEN; MELLITUS
AB Iron may contribute to the pathogenesis of type 2 diabetes mellitus (DM) by inducing oxidative stress and interfering with insulin secretion. Elevated ferritin levels are associated with increased DM risk among healthy individuals. However, it is yet unknown if ferritin predicts DM incidence among high-risk individuals with impaired glucose tolerance (IGT). Furthermore, the association between soluble transferrin receptors (sTfR), a novel marker of iron status, and DM risk has not yet been prospectively investigated in these individuals. We conducted this study to evaluate the association between baseline levels of ferritin and sTfR and the risk of developing DM among overweight and obese individuals at high risk of DM.
   This nested case-control study (280 cases and 280 matched controls) was conducted within the placebo arm of the Diabetes Prevention Program, is a clinical trial conducted among overweight/obese individuals with IGT. Ferritin and sTfR levels were measured by immunoturbidimetric assays. Incident DM was ascertained by annual 75-g oral glucose tolerance test and semi-annual fasting glucose.
   Compared with controls, cases had higher sTfR levels (3.50 +/- 0.07 vs. 3.30 +/- 0.06 mg/l; p = 0.03), but ferritin levels were not statistically different. The multivariable odds ratios (OR) and 95% confidence intervals (95% CI) for DM incidence comparing highest with the lowest quartiles of sTfR was 2.26 (1.37-4.01) (p-trend: 0.008).
   Modestly elevated sTfR levels are associated with increased DM risk among overweight and obese individuals with IGT. Future studies should evaluate factors determining sTfR levels and examine if interventions that lower body iron stores reduce DM incidence.
C1 [Rajpathak, S. N.; Wylie-Rosett, J.; Gunter, M. J.; Negassa, A.; Kabat, G. C.; Rohan, T. E.] Albert Einstein Coll Med, Dept Epidemiol & Populat Hlth, Bronx, NY 10461 USA.
   [Crandall, J.] Albert Einstein Coll Med, Div Endocrinol, Dept Med, Bronx, NY 10461 USA.
C3 Yeshiva University; Montefiore Medical Center; Albert Einstein College
   of Medicine; Montefiore Medical Center; Albert Einstein College of
   Medicine; Yeshiva University
RP Rajpathak, SN (corresponding author), Albert Einstein Coll Med, Dept Epidemiol & Populat Hlth, Bronx, NY 10461 USA.
EM srajpath@aecom.yu.edu
RI Gunter, Marc/AAP-8621-2020
FU NIH-funded Diabetes Research and Training Center [5P60DK20541]; Indian
   Health Service; General Clinical Research Center Program; Office of
   Research on Minority Health; National Institute of Child Health and
   Human Development; National Institute in Aging, the Centers for Disease
   Control and Prevention; American Diabetes Association
FX This study was supported by a Pilot and Feasibility Grant from the
   NIH-funded Diabetes Research and Training Center (5P60DK20541) at the
   Albert Einstein College of Medicine, NY. Support for the Diabetes
   Prevention Program was provided by the National Institute of Diabetes,
   and Digestive and Kidney Diseases. Additional support was provided for
   some centres by the Indian Health Service, the General Clinical Research
   Center Program, the Office of Research on Minority Health, the National
   Institute of Child Health and Human Development, the National Institute
   in Aging, the Centers for Disease Control and Prevention, and the
   American Diabetes Association. We gratefully acknowledge the dedication
   of the participants of the DPP.
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NR 70
TC 66
Z9 70
U1 0
U2 20
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1462-8902
EI 1463-1326
J9 DIABETES OBES METAB
JI Diabetes Obes. Metab.
PD MAY
PY 2009
VL 11
IS 5
BP 472
EP 479
DI 10.1111/j.1463-1326.2008.00985.x
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 433RX
UT WOS:000265224600008
PM 19207293
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Demirkol, S
   Balta, S
   Kucuk, U
   Celik, T
   Arslan, Z
   Kucuk, HO
   Unlu, M
   Yuksel, UC
   Samedli, S
   Yokusoglu, M
   Iyisoy, A
   Kursaklioglu, H
AF Demirkol, S.
   Balta, S.
   Kucuk, U.
   Celik, T.
   Arslan, Z.
   Kucuk, H. Olgun
   Unlu, M.
   Yuksel, U. Cagdas
   Samedli, S.
   Yokusoglu, M.
   Iyisoy, A.
   Kursaklioglu, H.
TI Association between microvascular angina and erectile dsyfunction
SO INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH
LA English
DT Article
DE cardiac syndrome X; erectile dysfunction; endothelial dysfunction
ID CARDIAC SYNDROME-X; ENDOTHELIAL DYSFUNCTION; OXIDATIVE STRESS;
   NITRIC-OXIDE; PATHOPHYSIOLOGY; PHYSIOLOGY; BLOOD; FLOW
AB Although the origin of cardiac syndrome X (CSX) is still debated, endothelial dysfunction leading to reduced coronary microvascular dilatory response and increased coronary resistance is thought to have an important role in the pathogenesis. Erectile dysfunction (ED) is associated with risk factors resulting in endotelial dysfunction. Although the relationship between cardiovascular disease and ED has been well established; the relation between CSX and ED has not been extensively studied so far. We herein aimed to study ED in patients with CSX. The study was designed as a prospective case-control study. Blood samples were analyzed with respect to concentrations of low-density lipoprotein cholesterol, high-density lipoprotein cholesterol and triglycerides. The subjects answered the native language five-item version of the International Index of Erectile Function Questionnaire (IIEF)-5. Each question was scored from 0 to 5 with a maximum score of 25 denoting healty subjects. We investigated the IIEF-5 score in 51 men with CSX (mean age 48.2 +/- 6.4 years), 53 men with demonstrated coronary artery disease (CAD) (mean age 48.3 +/- 4.8 years) and 52 male controls with normal coronary arteries (mean age 47.2 +/- 6.0 years). Mean IIEF-5 scores were 19.88 +/- 3.07 for CSX group, 18.83 +/- 3.31 for CAD group and 21.40 +/- 2.94 for control group. IIEF-5 scores in CSX group were found to be significantly lower than the those of control group (P<0.001). There were no significant differences in IIEF-5 scores between CSX and CAD groups (P = 0.09). We have shown for the first time that patients with CSX have lower IIEF-5 scores compared with controls with normal coronary angiograms. This study suggests that ED and CSX may be different manifestations of a common underlying vascular pathology and vasculogenic ED is frequently seen in CSX at least as much as in CAD.
C1 [Demirkol, S.; Balta, S.; Kucuk, U.; Celik, T.; Yuksel, U. Cagdas; Samedli, S.; Yokusoglu, M.; Iyisoy, A.; Kursaklioglu, H.] Gulhane Mil Med Acad, Sch Med, Dept Cardiol, Ankara, Turkey.
   [Arslan, Z.] Gelibolu Mil Hosp, Dept Cardiol, Canakkale, Turkey.
   [Kucuk, H. Olgun] Gazi Med Fac, Dept Cardiol, Ankara, Turkey.
   [Unlu, M.] Beytepe Mil Hosp, Dept Cardiol, Ankara, Turkey.
C3 Gulhane Military Medical Academy; Gallipoli Military Hospital; Gazi
   University; Beytepe Military Hospital
RP Demirkol, S (corresponding author), Gulhane Mil Med Acad, Dept Cardiol, Tevfik Saglam St, TR-06018 Etlik, Turkey.
EM saitdemirkol@yahoo.com
RI yuksel, uygar/AAA-5958-2021; Celik, Turgay/I-2981-2019
OI Balta, Sevket/0000-0002-6657-7334; Arslan, Zekeriya/0000-0003-1497-1396;
   Celik, Turgay/0000-0001-8418-0130
CR Agarwal A, 2006, J ANDROL, V27, P335, DOI 10.2164/jandrol.05136
   Akcay AB, 2011, INT J IMPOT RES, V23, P128, DOI 10.1038/ijir.2011.10
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NR 23
TC 10
Z9 10
U1 0
U2 3
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0955-9930
EI 1476-5489
J9 INT J IMPOT RES
JI Int. J. Impot. Res.
PD JUL-AUG
PY 2014
VL 26
IS 4
BP 124
EP 127
DI 10.1038/ijir.2013.49
PG 4
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA AL6RR
UT WOS:000339261000002
PM 24352245
DA 2025-06-11
ER

PT J
AU Pozzi, E
   Capogrosso, P
   Chierigo, F
   Pederzoli, F
   Ventimiglia, E
   Boeri, L
   Frego, N
   Moretti, D
   Dehò, F
   Montorsi, F
   Salonia, A
AF Pozzi, Edoardo
   Capogrosso, Paolo
   Chierigo, Francesco
   Pederzoli, Filippo
   Ventimiglia, Eugenio
   Boeri, Luca
   Frego, Nicola
   Moretti, Donatella
   Deho, Federico
   Montorsi, Francesco
   Salonia, Andrea
TI Clinical Profile of Young Patients with Erectile Dysfunction:
   Preliminary Findings of a Real-life Cross-sectional Study
SO EUROPEAN UROLOGY FOCUS
LA English
DT Article
DE Erectile dysfunction; Age; Young; Risk factors; Depression;
   International Index of Erectile; Function; Health status; Beck's
   Inventory for Depression
ID INTERNATIONAL INDEX; SEXUAL DYSFUNCTIONS; METABOLIC SYNDROME; MEN;
   PREVALENCE; RISK; ASSOCIATION; DEPRESSION; SYMPTOMS
AB Background: Erectile dysfunction (ED) is an increasingly common complaint among men aged <40 yr.
   Objective: To assess clinical factors potentially associated with impaired erectile function (EF) in a cohort of young men seeking first medical help for ED as their primary complaint.
   Design, setting, and participants: Complete sociodemographic and clinical data for 307 consecutive patients aged <40 yr were analysed. Health-significant comorbidities were scored using the Charlson comorbidity index. Patients completed the International Index of Erectile Function (IIEF) and Beck's Inventory for Depression (BDI) and were categorised into two groups: those with impaired EF (IIEF-EF <26) and those with normal IIEF-EF scores.
   Outcome measurements and statistical analysis: Descriptive statistics and logistic regression analyses were used to test the association between risk factors and impaired EF.
   Results and limitations: Overall, 78 patients (25%) had normal and 229 (75%) had impaired IIEF-EF scores. Among ED patients, 90 (29%) had IIEF-EF scores suggestive of severe ED. The two cohorts did not differ in terms of median age, body mass index, prevalence of hypertension, general health status, smoking history, or alcohol use. No differences were reported for serum sex hormones and lipid profiles. Patients with ED reported higher median BDI scores (7, interquartile range [IQR] 3-13) than those with normal EF (5, IQR 1-9). Overall, the higher the BDI score, the lower was the IIEF-EF domain score (odds ratio 1.08, 95% confidence interval 1.02-1.15; p = 0.01). The single-centre cohort is the main study limitation.
   Conclusions: Overall, young men with impaired EF showed comparable clinical characteristics to those with normal IIEF-EF; conversely, young individuals with worse EF had BDI scores suggestive of significant mood deflection.
   Patient summary: Young men complaining of erectile dysfunction show significant mood deflection in comparison to patients with normal erectile function. Conversely, the clinical characteristics are similar between the two groups. (C) 2018 Published by Elsevier B.V. on behalf of European Association of Urology.
C1 [Pozzi, Edoardo; Capogrosso, Paolo; Chierigo, Francesco; Pederzoli, Filippo; Ventimiglia, Eugenio; Boeri, Luca; Frego, Nicola; Moretti, Donatella; Deho, Federico; Montorsi, Francesco; Salonia, Andrea] IRCCS Osped San Raffaele, Div Expt Oncol, Urol Res Inst, Unit Urol, Via Olgettina 60, I-20132 Milan, Italy.
   [Pozzi, Edoardo; Chierigo, Francesco; Pederzoli, Filippo; Ventimiglia, Eugenio; Montorsi, Francesco; Salonia, Andrea] Univ Vita Salute San Raffaele, Milan, Italy.
   [Boeri, Luca] Univ Milan, Fdn IRCCS Ca Granda Osped Maggiore Policlin, UOC Urol, Milan, Italy.
C3 Vita-Salute San Raffaele University; IRCCS Ospedale San Raffaele;
   Vita-Salute San Raffaele University; IRCCS Ca Granda Ospedale Maggiore
   Policlinico; University of Milan
RP Salonia, A (corresponding author), IRCCS Osped San Raffaele, Div Expt Oncol, Urol Res Inst, Unit Urol, Via Olgettina 60, I-20132 Milan, Italy.
EM salonia.andrea@hsr.it
RI Pozzi, Edoardo/AAC-5170-2019; Ventimiglia, Eugenio/ABI-2333-2020;
   Montorsi, Francesco/AAN-2473-2020; Boeri, Luca/AAC-4848-2022; Chierigo,
   Francesco/ABE-9462-2021; Deho, Federico/K-4505-2018; Pederzoli,
   Filippo/K-2383-2018; Salonia, Andrea/H-1025-2016; Chierigo,
   Francesco/AFZ-9935-2022
OI Pozzi, Edoardo/0000-0002-0228-7039; Pederzoli,
   Filippo/0000-0003-3873-7465; Capogrosso, Paolo/0000-0003-2347-9504;
   Salonia, Andrea/0000-0002-0595-7165; Chierigo,
   Francesco/0000-0001-7357-0758
CR [Anonymous], EAU GUIDELINES MALE
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NR 27
TC 13
Z9 14
U1 0
U2 3
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
EI 2405-4569
J9 EUR UROL FOCUS
JI Eur. Urol. Focus
PD JAN 15
PY 2020
VL 6
IS 1
BP 184
EP 189
DI 10.1016/j.euf.2018.10.003
PG 6
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA KA4PZ
UT WOS:000505780500034
PM 30316826
DA 2025-06-11
ER

PT J
AU Sedky, AA
   Magdy, Y
AF Sedky, Amina Ahmed
   Magdy, Yosra
TI Reduction in TNF alpha and oxidative stress by liraglutide: Impact on
   ketamine-induced cognitive dysfunction and hyperlocomotion in rats
SO LIFE SCIENCES
LA English
DT Article
DE GLP-1; Diabetes; High-fat diet; BDNF; Psychotic disorders; MDA;
   Hippocampus; Streptozotocin
ID GLUCAGON-LIKE PEPTIDE-1; HIGH-FAT DIET; NEUROTROPHIC FACTOR; BIPOLAR
   DISORDER; INSULIN-RESISTANCE; MOUSE MODEL; METABOLIC SYNDROME;
   EXPRESSION; SCHIZOPHRENIA; SITAGLIPTIN
AB Background: Diabetes and psychotic disorders are occasionally comorbid. Possible pathophysiologies linking these disorders include inflammation and oxidative stress. Glucagon like peptide-1 (GLP-1) agonists modulate glucose metabolism and may exert neuroprotective effects via central GLP-1 receptors. Aim of the work: To explore the effects of GLP-1 agonist, liraglutide, on ketamine-induced hyper-locomotion and cognitive dysfunction and the associated inflammation and oxidative stress in normoglycemic and diabetic rats.
   Methods: Rats were divided into: Chow fed (non-diabetic) and high fat diet fed/STZ (diabetic) groups: I. nondiabetic/control, non-diabetic/liraglutide, non-diabetic/ketamine, non-diabetic/ketamine/liraglutide groups. II. diabetic/control, diabetic/liraglutide, diabetic/ketamine and diabetic/ketamine/liraglutide groups. Hyperlocomotion and cognitive dysfunction were assessed using open field and water maze tests. Biochemical parameters were measured in serum and hippocampus.
   Results: Ketamine induced hyperlocomotion and cognitive dysfunction, with hippocampal histopathological changes. Increase in tumour necrosis factor (TNF)-alpha and oxidative stress and reduction in brain-derived neurotrophic factor (BDNF) were noted. These changes were augmented in diabetic compared to non-diabetic rats. Liraglutide significantly improved hyperlocomotion, and cognitive dysfunction and hippocampal histopathological changes in non-diabetic and diabetic rats. Improvement in glucose homeostasis, reduction in TNF alpha and malondialdehyde, and increase in glutathione and BDNF were observed in serum and hippocampus.
   Conclusion: Beneficial effects of liraglutide on ketamine-induced hyperlocomotion and cognitive dysfunction are associated with reduction in TNF alpha and oxidative stress. Since effects of liraglutide occurred in diabetic and non-diabetic rats, glycemic and non-glycemic effects (via central GLP-1 receptors) might be involved. Targeting oxidative stress and inflammation by GLP-1 agonists, may be a promising approach in psychotic patients with diabetes.
C1 [Sedky, Amina Ahmed; Magdy, Yosra] Ain Shams Univ, Dept Pharmacol, Cairo, Egypt.
C3 Egyptian Knowledge Bank (EKB); Ain Shams University
RP Sedky, AA (corresponding author), Ain Shams Univ, Dept Pharmacol, Fac Med, Cairo, Egypt.
EM aminasedky@hotmail.com
OI magdy, yosra/0000-0002-1226-3057
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   BRAIN RES BULL
NR 70
TC 12
Z9 13
U1 1
U2 8
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0024-3205
EI 1879-0631
J9 LIFE SCI
JI Life Sci.
PD AUG 1
PY 2021
VL 278
AR 119523
DI 10.1016/j.lfs.2021.119523
EA MAY 2021
PG 12
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA SU7OM
UT WOS:000663321900004
PM 33891942
DA 2025-06-11
ER

PT J
AU Sánchez-Rodríguez, MA
   Mendoza-Núñez, VM
AF Sanchez-Rodriguez, Martha A.
   Manuel Mendoza-Nunez, Victor
TI Oxidative Stress Indexes for Diagnosis of Health or Disease in Humans
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Review
ID OXIDANT-ANTIOXIDANT BALANCE; ENDOTHELIAL FUNCTION; FREE-RADICALS;
   LIVER-TRANSPLANTATION; CHRONIC PERIODONTITIS; POSTMENOPAUSAL WOMEN;
   INSULIN-RESISTANCE; COLORECTAL ADENOMA; GLUTATHIONE STATUS; METABOLIC
   SYNDROME
AB Oxidative stress (OS) is the imbalance between oxidant and antioxidant molecules, in favor of oxidants, that causes aging and disease. Many studies have been published that demonstrate the relationship between OS and human health and disease; however, the following questions arise: (i) how are we sure that the OS is present in a biological process? (ii) Is the OS reported in the different investigations equivalent? (iii) What are the best oxidant and antioxidant markers for OS diagnosis? (iv) Can we establish the types and the intensity of the OS? (v) Does OS index could be useful for research and/or application in clinical medicine? In this regard, several indexes have been proposed to measure OS in humans relative to the state of health and disease, among which the following can be highlighted: Oxidative Stress Index (OSI), Tiol Ratios (-SH/TT, -SS/-SH, and-SS/TT), Glutathione Ratio (GSSG/GSH), Oxidative Stress Score (OSS), and OXY-index. Therefore, the aim of this review is to present the state of the art of knowledge about OS indexes for diagnosis of health or disease in humans. We searched for articles in English or Spanish in the PubMed/MEDLINE and Scopus electronic databases published up until May 2019. The keywords used were "oxidative stress," "index," and "oxidative stress index." It was identified 11479 records in both databases, and 490 articles were analyzed. Our review suggests that all indexes analyzed allow diagnose and differentiate the OS related to human health and disease. Also, the studies on OSI, Oxy-score, and OSS indexes have proven to be reliable, practical, and with clinical utility. However, it is necessary to continue with longitudinal studies, especially assess the usefulness of the indexes in the clinical prognosis, and make comparative studies between the different indexes.
C1 [Sanchez-Rodriguez, Martha A.; Manuel Mendoza-Nunez, Victor] Univ Nacl Autonoma Mexico, Fac Estudios Super Zaragoza, Unidad Invest Gerontol, Av Guelatao 66, Ciudad De Mexico 09230, Mexico.
C3 Universidad Nacional Autonoma de Mexico
RP Mendoza-Núñez, VM (corresponding author), Univ Nacl Autonoma Mexico, Fac Estudios Super Zaragoza, Unidad Invest Gerontol, Av Guelatao 66, Ciudad De Mexico 09230, Mexico.
EM mendovic@unam.mx
RI Mendoza-Núñez, Víctor Manuel/AFL-2465-2022; Sanchez-Rodriguez,
   Martha/N-3528-2017
OI Mendoza-Nunez, Victor Manuel/0000-0002-9137-3405
FU Secretaria de Educacion, Ciencia, Tecnologia e Innovacion de la Ciudad
   de Mexico "Red colaborativa de Investigacion Traslacional para el
   Envejecimiento Saludable de la Ciudad de Mexico (RECITES)"
   [SECITI/042/2018]; "Programa para la Investigacion Bibliografica
   Cientifica sobre Salud (PIBCIS)" Facultad de Estudios Superiores
   Zaragoza, Universidad Nacional Autonoma de Mexico
FX This project was supported by a grant from the Secretaria de Educacion,
   Ciencia, Tecnologia e Innovacion de la Ciudad de Mexico SECITI/042/2018
   "Red colaborativa de Investigacion Traslacional para el Envejecimiento
   Saludable de la Ciudad de Mexico (RECITES)" and also by "Programa para
   la Investigacion Bibliografica Cientifica sobre Salud (PIBCIS)" Facultad
   de Estudios Superiores Zaragoza, Universidad Nacional Autonoma de
   Mexico.
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NR 172
TC 123
Z9 128
U1 3
U2 16
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PD NOV 25
PY 2019
VL 2019
AR 4128152
DI 10.1155/2019/4128152
PG 32
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA JU6CB
UT WOS:000501761500002
PM 31885788
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Alleman, RJ
   Katunga, LA
   Nelson, MAM
   Brown, DA
   Anderson, EJ
AF Alleman, Rick J.
   Katunga, Lalage A.
   Nelson, Margaret A. M.
   Brown, David A.
   Anderson, Ethan J.
TI The "Goldilocks Zone" from a redox perspective-Adaptive vs. deleterious
   responses to oxidative stress in striated muscle
SO FRONTIERS IN PHYSIOLOGY
LA English
DT Review
DE hormesis; carbonyl stress; mitochondria; lipid peroxidation; redox
   environment; adaptation; heart; skeletal muscle
ID PERMEABILITY TRANSITION PORE; K-ATP CHANNELS; ALDEHYDE DEHYDROGENASE 2;
   NADPH OXIDASE ACTIVITY; REACTIVE OXYGEN; LIPID-PEROXIDATION;
   MONOAMINE-OXIDASE; SKELETAL-MUSCLE; MITOCHONDRIAL RESPIRATION; CARDIAC
   MITOCHONDRIA
AB Consequences of oxidative stress may be beneficial or detrimental in physiological systems. An organ system's position on the "hormetic curve" is governed by the source and temporality of reactive oxygen species (ROS) production, proximity of ROS to moieties most susceptible to damage, and the capacity of the endogenous cellular ROS scavenging mechanisms. Most importantly, the resilience of the tissue (the capacity to recover from damage) is a decisive factor, and this is reflected in the disparate response to ROS in cardiac and skeletal muscle. In myocytes, a high oxidative capacity invariably results in a significant ROS burden which in homeostasis, is rapidly neutralized by the robust antioxidant network. The up-regulation of key pathways in the antioxidant network is a central component of the hormetic response to ROS. Despite such adaptations, persistent oxidative stress over an extended time-frame (e.g., months to years) inevitably leads to cumulative damages, maladaptation and ultimately the pathogenesis of chronic diseases. Indeed, persistent oxidative stress in heart and skeletal muscle has been repeatedly demonstrated to have causal roles in the etiology of heart disease and insulin resistance, respectively. Deciphering the mechanisms that underlie the divergence between adaptive and maladaptive responses to oxidative stress remains an active area of research for basic scientists and clinicians alike, as this would undoubtedly lead to novel therapeutic approaches. Here, we provide an overview of major types of ROS in striated muscle and the divergent adaptations that occur in response to them. Emphasis is placed on highlighting newly uncovered areas of research on this topic, with particular focus on the mitochondria, and the diverging roles that ROS play in muscle health (e.g., exercise or preconditioning) and disease (e.g., cardiomyopathy, ischemia, metabolic syndrome).
C1 [Alleman, Rick J.; Brown, David A.] E Carolina Univ, Dept Physiol, Greenville, NC 27834 USA.
   [Alleman, Rick J.; Katunga, Lalage A.; Nelson, Margaret A. M.; Brown, David A.; Anderson, Ethan J.] E Carolina Univ, East Carolina Diabet & Obes Inst, Greenville, NC 27834 USA.
   [Katunga, Lalage A.; Nelson, Margaret A. M.; Anderson, Ethan J.] E Carolina Univ, Brody Sch Med, Greenville, NC 27834 USA.
C3 University of North Carolina; East Carolina University; University of
   North Carolina; East Carolina University; University of North Carolina;
   East Carolina University
RP Anderson, EJ (corresponding author), E Carolina Univ, Brody Sch Med, Dept Pharmacol & Toxicol, 6S-10,600 Moye Blvd, Greenville, NC 27834 USA.
EM andersonet@ecu.edu
OI , Margaret Nelson/0009-0005-8612-8359
FU NHLBI NIH HHS [R01 HL122863] Funding Source: Medline
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NR 245
TC 62
Z9 72
U1 0
U2 17
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-042X
J9 FRONT PHYSIOL
JI Front. Physiol.
PD SEP 18
PY 2014
VL 5
AR 358
DI 10.3389/fphys.2014.00358
PG 20
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA AX7IP
UT WOS:000347090200001
PM 25278906
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Murer, SB
   Aeberli, I
   Braegger, CP
   Gittermann, M
   Hersberger, M
   Leonard, SW
   Taylor, AW
   Traber, MG
   Zimmermann, MB
AF Murer, Stefanie B.
   Aeberli, Isabelle
   Braegger, Christian P.
   Gittermann, Matthias
   Hersberger, Martin
   Leonard, Scott W.
   Taylor, Alan W.
   Traber, Maret G.
   Zimmermann, Michael B.
TI Antioxidant Supplements Reduced Oxidative Stress and Stabilized Liver
   Function Tests but Did Not Reduce Inflammation in Randomized Controlled
   Trial in Obese Children and Adolescents
SO JOURNAL OF NUTRITION
LA English
DT Article
ID C-REACTIVE PROTEIN; PERFORMANCE LIQUID-CHROMATOGRAPHY; CARDIOVASCULAR
   RISK-FACTORS; BODY-MASS INDEX; FATTY LIVER; VITAMIN-E; ALPHA-TOCOPHEROL;
   INSULIN-RESISTANCE; METABOLIC-SYNDROME; BETA-CAROTENE
AB Oxidative stress and low-grade systemic inflammation may contribute to the pathogenesis of obesity-induced comorbidities, including nonalcoholic fatty liver disease. Increasing intake of dietary antioxidants might be beneficial, but there are few data in obese children. To examine the effect of antioxidant supplementation on biomarkers of oxidative stress, inflammation, and liver function, we randomly assigned overweight or obese children and adolescents (n = 44; mean +/- SD age: 12.7 +/- 1.5 y) participating in a lifestyle modification program to a 4-mo intervention with daily antioxidants (vitamin E, 400 IU; vitamin C, 500mg; selenium, 50 mu g) or placebo. We measured anthropometrics, antioxidant status, oxidative stress (F-2-isoprostanes, F-2-isoprostane metabolites), inflammation, liver enzymes, fasting insulin and glucose, and lipid profile at baseline and endpoint. There was a significant treatment effect of antioxidant supplementation on antioxidant status [alpha-tocopherol, beta = 23.2(95% Cl: 18.0, 28.4); ascorbic acid, beta = 70.6(95% Cl: 51.7, 89.4); selenium, beta = 0.07(95% Cl: 0.01, 0.12)] and oxidative stress [8-iso-prostaglandin F-2 alpha,beta = -0.11(95% Cl: -0.19, -0.02)] but not on any of the inflammatory markers measured. There was a significant treatment effect on alanine aminotransferase (beta = -0.13 (95% Cl: -0.23, -0.03)), a trend toward a significant effect on aspartate aminotransferase [beta = -0.04 (95% Cl: -0.09, 0.01)], and no significant effect on gamma-glutamyltransferase [beta = -0.03(95% Cl: -0.11, 0.06)]. In summary, antioxidant supplementation for 4 mo improved antioxidant-oxidant balance and modestly improved liver function tests; however, it did not reduce markers of systemic inflammation despite significant baseline correlations between oxidative stress and inflammation. The study was registered at clinicaltrials.gov as NCT01316081.
C1 [Murer, Stefanie B.; Aeberli, Isabelle; Zimmermann, Michael B.] ETH, Inst Food Nutr & Hlth, Human Nutr Lab, Zurich, Switzerland.
   [Aeberli, Isabelle] Univ Zurich Hosp, Dept Endocrinol Diabet & Clin Nutr, CH-8091 Zurich, Switzerland.
   [Braegger, Christian P.] Univ Childrens Hosp Zurich, Div Gastroenterol & Nutr, Zurich, Switzerland.
   [Hersberger, Martin] Univ Childrens Hosp Zurich, Div Clin Chem & Biochem, Zurich, Switzerland.
   [Gittermann, Matthias] Cantonal Childrens Hosp, Aarau, Switzerland.
   [Leonard, Scott W.; Taylor, Alan W.; Traber, Maret G.] Oregon State Univ, Linus Pauling Inst, Corvallis, OR 97331 USA.
C3 Swiss Federal Institutes of Technology Domain; ETH Zurich; University of
   Zurich; University Zurich Hospital; University Children's Hospital
   Zurich; University Children's Hospital Zurich; Oregon State University
RP Murer, SB (corresponding author), ETH, Inst Food Nutr & Hlth, Human Nutr Lab, Zurich, Switzerland.
EM stefanie.murer@hest.ethz.ch
RI Traber, Maret/ABI-2511-2020; Braegger, Christian/ABC-9884-2021;
   Zimmermann, Michael/C-3062-2016; Herter-Aeberli, Isabelle/C-8580-2013
OI Braegger, Christian/0000-0001-8069-9875; Traber,
   Maret/0000-0002-2892-4024; Herter-Aeberli, Isabelle/0000-0003-0134-6217;
   Leonard, Scott/0000-0001-9967-7078; Hersberger,
   Martin/0000-0002-4472-329X
FU Swiss Foundation for Nutrition Research; Vontobel Foundation; ETH Zurich
FX Supported by the Swiss Foundation for Nutrition Research, the Vontobel
   Foundation, and ETH Zurich. Burgerstein Vitamins (Rapperswil-Jona,
   Switzerland) provided the antioxidant and placebo capsules.
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NR 84
TC 60
Z9 67
U1 0
U2 16
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0022-3166
EI 1541-6100
J9 J NUTR
JI J. Nutr.
PD FEB
PY 2014
VL 144
IS 2
BP 193
EP 201
DI 10.3945/jn.113.185561
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 294XF
UT WOS:000330080500012
PM 24353344
OA Bronze
DA 2025-06-11
ER

PT J
AU Cheng, K
   Ho, K
   Stokes, R
   Scott, C
   Lau, SM
   Hawthorne, WJ
   O'Connell, PJ
   Loudovaris, T
   Kay, TW
   Kulkarni, RN
   Okada, T
   Wang, XHL
   Yim, SH
   Shah, Y
   Grey, ST
   Biankin, AV
   Kench, JG
   Laybutt, DR
   Gonzalez, FJ
   Kahn, CR
   Gunton, JE
AF Cheng, Kim
   Ho, Kenneth
   Stokes, Rebecca
   Scott, Christopher
   Lau, Sue Mei
   Hawthorne, Wayne J.
   O'Connell, Philip J.
   Loudovaris, Thomas
   Kay, Thomas W.
   Kulkarni, Rohit N.
   Okada, Terumasa
   Wang, Xiaohui L.
   Yim, Sun Hee
   Shah, Yatrik
   Grey, Shane T.
   Biankin, Andrew V.
   Kench, James G.
   Laybutt, D. Ross
   Gonzalez, Frank J.
   Kahn, C. Ronald
   Gunton, Jenny E.
TI Hypoxia-inducible factor-1α regulates β cell function in mouse and human
   islets
SO JOURNAL OF CLINICAL INVESTIGATION
LA English
DT Article
ID ENDOTHELIAL GROWTH-FACTOR; HIPPEL-LINDAU-DISEASE; INSULIN-RESISTANCE
   SYNDROME; CORONARY-HEART-DISEASE; FACTOR 1-ALPHA; PANCREATIC-ISLETS;
   SERUM FERRITIN; IRON STORES; PROLYL HYDROXYLATION; EMBRYONIC LETHALITY
AB Hypoxia-inducible factor-1 alpha (HIF-1 alpha) is a transcription factor that regulates cellular stress responses. While the levels of HIF-1 alpha protein are tightly regulated, recent studies suggest that it can be active under normoxic conditions. We hypothesized that HIF-1 alpha is required for normal beta cell function and reserve and that dysregulation may contribute to the pathogenesis of type 2 diabetes (T2D). Here we show that HIF-1 alpha protein is present at low levels in mouse and human normoxic beta cells and islets. Decreased levels of HIF-1 alpha impaired glucose-stimulated ATP generation and beta cell function. C57BL/6 mice with beta cell-specific Hif1a disruption (referred to herein as beta-Hif1a-null mice) exhibited glucose intolerance, beta cell dysfunction, and developed severe glucose intolerance on a high-fat diet. Increasing HIP-1 alpha levels by inhibiting its degradation through iron chelation markedly improved insulin secretion and glucose tolerance in control mice fed a high-fat diet but not in beta-Hif1a-null mice. Increasing HIF-1 alpha levels markedly increased expression of ARNT and other genes in human T2D islets and improved their function. Further analysis indicated that HIF-1 alpha was bound to the Arnt promoter in a mouse beta cell line, suggesting direct regulation. Taken together, these findings suggest an important role for HIF-1 alpha in beta cell reserve and regulation of ARNT expression and demonstrate that HIF-1 alpha is a potential therapeutic target for the beta cell dysfunction of T2D.
C1 [Cheng, Kim; Ho, Kenneth; Stokes, Rebecca; Scott, Christopher; Lau, Sue Mei; Gunton, Jenny E.] Garvan Inst Med Res, Diabet & Transcript Factors Grp, Sydney, NSW 2010, Australia.
   [Hawthorne, Wayne J.; O'Connell, Philip J.] Univ Sydney, Ctr Transplantat & Renal Res, Westmead Res Inst, Westmead Hosp, Sydney, NSW 2006, Australia.
   [Loudovaris, Thomas; Kay, Thomas W.] St Vincents Inst, Melbourne, Vic, Australia.
   [Kulkarni, Rohit N.; Okada, Terumasa; Wang, Xiaohui L.; Kahn, C. Ronald] Joslin Diabet Ctr, Boston, MA 02215 USA.
   [Kulkarni, Rohit N.; Okada, Terumasa; Wang, Xiaohui L.; Kahn, C. Ronald] Harvard Univ, Sch Med, Boston, MA USA.
   [Yim, Sun Hee; Shah, Yatrik; Gonzalez, Frank J.] NCI, Lab Metab, Bethesda, MD 20892 USA.
   [Shah, Yatrik] Univ Michigan, Dept Internal Med, Div Gastroenterol, Ann Arbor, MI 48109 USA.
   [Grey, Shane T.] GIMR, Gene Therapy & Autoimmun Grp, Sydney, NSW, Australia.
   [Biankin, Andrew V.; Kench, James G.] GIMR, Canc Res Program, Sydney, NSW, Australia.
   [Biankin, Andrew V.] Bankstown Hosp, Dept Surg, Sydney, NSW, Australia.
   [Laybutt, D. Ross] GIMR, Diabet & Obes Res Program, Sydney, NSW, Australia.
   [Gunton, Jenny E.] Univ Sydney, Fac Med, Sydney, NSW 2006, Australia.
   [Gunton, Jenny E.] Univ New S Wales, St Vincents Clin Sch, Sydney, NSW, Australia.
   [Gunton, Jenny E.] Westmead Hosp, Dept Endocrinol & Diabet, Sydney, NSW, Australia.
C3 Garvan Institute of Medical Research; University of Sydney; NSW Health;
   Westmead Hospital; St. Vincent's Institute of Medical Research; Harvard
   University; Harvard University Medical Affiliates; Joslin Diabetes
   Center, Inc.; Harvard University; Harvard Medical School; National
   Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI);
   University of Michigan System; University of Michigan; NSW Health;
   Bankstown Lidcombe Hospital; University of Sydney; University of New
   South Wales Sydney; University of Sydney; NSW Health; Westmead Hospital
RP Gunton, JE (corresponding author), Garvan Inst Med Res, Diabet & Transcript Factors Grp, 384 Victoria St, Sydney, NSW 2010, Australia.
EM j.gunton@garvan.org.au
RI O'Connell, Philip/AFK-9353-2022; Kahn, Ronald/AAY-2435-2021; Ho,
   Ken/AAA-7428-2019; Gonzalez, Francisco/GWV-3999-2022; Gunton,
   Jenny/AAH-7719-2021; Grey, Shane/B-3020-2008
OI Kench, James Geoffrey/0000-0001-8687-4988; Laybutt, David
   Ross/0009-0005-1943-8859; Lau, Sue Mei/0000-0002-7351-3064; Gonzalez,
   Frank/0000-0002-7990-2140; Grey, Shane/0000-0003-2160-1625; Biankin,
   Andrew/0000-0002-0362-5597
FU National Health and Medical Research Council of Australia (NHMRC);
   Diabetes Australia Research Trust; Juvenile Diabetes Research Foundation
   (JDRF); Royal Australasian College of Physicians Pfizer and Servier;
   L'Oreal Australian For Women in Science; NIH [RO1 DK33201, DK60837-02,
   K08, DK02885, RO1 DK67536]; Cancer Institute New South Wales
FX J.E. Gunton was funded by the National Health and Medical Research
   Council of Australia (NHMRC), Diabetes Australia Research Trust,
   Juvenile Diabetes Research Foundation (JDRF), the Royal Australasian
   College of Physicians Pfizer and Servier postdoctoral fellowships, and
   the L'Oreal Australian For Women in Science fellowship. W.J. Hawthorne,
   P.J. O'Connell, T. Loudovaris, and T.W. Kay were funded by JDRF and
   NHMRC. C.R. Kahn was supported by the Mary K. Iacocca Professorship and
   NIH grants RO1 DK33201 and DK60837-02. RN. Kulkarni was supported by NIH
   grants K08, DK02885, and RO1 DK67536. A.V. Biankin is supported by a
   Cancer Institute New South Wales fellowship. A.V. Biankin and J.G. Kench
   are supported by an NHMRC program grant. We would like to thank Andrew
   Dwyer, Sof Andrikopoulos, Cecile King, James Cantley, and Don Chisholm
   for helpful comments; Amber Johns for assistance with the human
   pancreatic slides; Alice Boulghourjian from the Garvan histology-core;
   Will Hughes from the Garvan microscope-core; Ed Feener from the Joslin
   Proteomics Core Facility DERC; staff at BTF for maintaining the mice;
   and Tina Patel and Lindy Williams from Westmead and Lina Mariana from
   St. Vincent's Melbourne for human islet isolations.
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NR 79
TC 190
Z9 213
U1 0
U2 18
PU AMER SOC CLINICAL INVESTIGATION INC
PI ANN ARBOR
PA 2015 MANCHESTER RD, ANN ARBOR, MI 48104 USA
SN 0021-9738
EI 1558-8238
J9 J CLIN INVEST
JI J. Clin. Invest.
PD JUN
PY 2010
VL 120
IS 6
BP 2171
EP 2183
DI 10.1172/JCI35846
PG 13
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 605CH
UT WOS:000278324400038
PM 20440072
OA Green Published
DA 2025-06-11
ER

PT J
AU May, M
   Barlow, D
   Ibrahim, R
   Houseknecht, KL
AF May, Meghan
   Barlow, Deborah
   Ibrahim, Radwa
   Houseknecht, Karen L.
TI Mechanisms Underlying Antipsychotic-Induced NAFLD and Iron
   Dysregulation: A Multi-Omic Approach
SO BIOMEDICINES
LA English
DT Article
DE NAFLD; NASH; antipsychotic; inflammation; insulin resistance; iron
   metabolism; anemia; psychiatry
ID FATTY LIVER-DISEASE; WEIGHT-GAIN; ATYPICAL ANTIPSYCHOTICS; PSYCHOTIC
   DISORDERS; METABOLIC SYNDROME; SCHIZOPHRENIA; DEFICIENCY; OVERLOAD;
   RATS; ASSOCIATION
AB Atypical antipsychotic (AA) medications are widely prescribed for the treatment of psychiatric disorders, including schizophrenia, bipolar disorder and treatment-resistant depression. AA are associated with myriad metabolic and endocrine side effects, including systemic inflammation, weight gain, dyslipidemia and insulin resistance, all of which are associated with increased incidence of non-alcoholic fatty liver disease (NAFLD). NAFLD is highly prevalent in patients with mental illness, and AA have been shown to increase incidence of NAFLD pre-clinically and clinically. However, the underlying mechanisms have not been described. We mined multi-omic datasets from preclinical murine models of sub-chronic risperidone or olanzapine treatment, in vitro exposure of human cells to risperidone and psychiatric patients following onset of aripiprazole therapy focused on pathways associated with the pathophysiology of NAFLD, including iron accumulation, systemic inflammation and dyslipidemia. We identified numerous differentially expressed traits affecting these pathways conserved across study systems and AA medications. We used these findings to propose mechanisms for AA-associated development of NAFLD and dysregulated iron homeostasis.
C1 [May, Meghan; Barlow, Deborah; Ibrahim, Radwa; Houseknecht, Karen L.] Univ New England, Coll Osteopath Med, Dept Biomed Sci, Biddeford, ME 04005 USA.
C3 University of New England - Maine
RP May, M; Houseknecht, KL (corresponding author), Univ New England, Coll Osteopath Med, Dept Biomed Sci, Biddeford, ME 04005 USA.
EM mmay3@une.edu; dbarlow@une.edu; ribrahiml@une.edu; khouseknecht@une.edu
OI Houseknecht, Karen/0000-0002-6967-9299
FU National Institutes of Health, NIDDK [DK095143]
FX This work was supported by the National Institutes of Health, NIDDK
   award number DK095143 to KLH.
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NR 54
TC 7
Z9 7
U1 0
U2 2
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2227-9059
J9 BIOMEDICINES
JI Biomedicines
PD JUN
PY 2022
VL 10
IS 6
AR 1225
DI 10.3390/biomedicines10061225
PG 12
WC Biochemistry & Molecular Biology; Medicine, Research & Experimental;
   Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Research & Experimental Medicine;
   Pharmacology & Pharmacy
GA 2K3AR
UT WOS:000816213700001
PM 35740245
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Kosuru, R
   Singh, S
AF Kosuru, Ramoji
   Singh, Sanjay
TI Pterostilbene ameliorates insulin sensitivity, glycemic control and
   oxidative stress in fructose-fed diabetic rats
SO LIFE SCIENCES
LA English
DT Article
DE Pterostilbene; Insulin resistance; Type 2 diabetes; HbA1c; Hepatic
   oxidative stress
ID HYDROGEN-SULFIDE; BLOOD-PRESSURE; RESISTANCE; PLASMA; MELLITUS; GLUCOSE;
   PEROXYNITRITE; RESVERATROL; ANTIOXIDANT; CHOLESTEROL
AB Aims: The present investigation was designed to explore the effectiveness of pterostilbene (PT) on insulin resistance, metabolic syndrome and oxidative stress in fructose-fed insulin resistant rats.
   Main methods: Age-matched, male Sprague-Dawley rats (330 +/- 30 g body weight) were allocated into five groups (n = 10). Control (C) group received 65% cornstarch, and the diabetic (D) group received 65% fructose for eight weeks. The third group (D + PT20) received 65% fructose and PT 20 mg/kg/day for eight weeks. The fourth group (D + PT40) received 65% fructose and PT 40 mg/kg/day for eight weeks. The fifth group (D + M) received 65% fructose and metformin (M) 100 mg/kg/day for eight weeks. PT was dissolved in 10% beta-cyclodextrin and given orally to rats. Several biochemical parameters were determined to assess the PT efficacy against insulin resistance, metabolic complications, and hepatic oxidative stress.
   Key findings: Significantly high HOMA-IR (p < 0.001) values in D group compared to C group indicate the presence of insulin resistance. Significantly high levels of TBARS (p < 0.001) and decreased levels of SOD (p < 0.001) and GSH (p < 0.001) in hepatic tissues of D group indicate oxidative stress associated with insulin resistance. Pterostilbene treatment to fructose-fed diabetic rats significantly decreased HOMA-IR (p < 0.001) values. Furthermore, PT treatment significantly decreased hepatic TBARS (p < 0.001) and increased SOD (p < 0.001) and GSH (p < 0.001) levels in fructose-fed diabetic rats.
   Significance: Current study reveals that PT is successful in ameliorating glycemic control, insulin sensitivity while diminishing metabolic disturbances and hepatic oxidative stress in a fructose-induced T2DM rat model. (C) 2017 Elsevier Inc. All rights reserved.
C1 [Kosuru, Ramoji; Singh, Sanjay] Banaras Hindu Univ, Indian Inst Technol, Dept Pharmaceut, Varanasi, Uttar Pradesh, India.
C3 Banaras Hindu University (BHU); Indian Institute of Technology System
   (IIT System); Indian Institute of Technology BHU Varanasi (IIT BHU
   Varanasi)
RP Singh, S (corresponding author), Banaras Hindu Univ, Indian Inst Technol, Dept Pharmaceut, Varanasi, Uttar Pradesh, India.
EM ssingh.phe@itbhu.ac.in
RI Kosuru, Ramoji/AAB-8320-2020; Singh, Sanjay/M-3276-2019
OI Kosuru, Ramoji/0000-0002-7394-7217
FU Ministry of Human Resource Development, Government of India
FX Ramoji Kosuru was supported by the Indian Institute of Technology
   (Banaras Hindu University), Varanasi for providing Teaching
   Assistantship funded by Ministry of Human Resource Development,
   Government of India. We gratefully acknowledge the Sami Labs Limited,
   Bangalore, India for providing pterostilbene as a generous gift sample.
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NR 60
TC 36
Z9 39
U1 1
U2 25
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0024-3205
EI 1879-0631
J9 LIFE SCI
JI Life Sci.
PD AUG 1
PY 2017
VL 182
BP 112
EP 121
DI 10.1016/j.lfs.2017.06.015
PG 10
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA EZ8JZ
UT WOS:000404972900014
PM 28629731
DA 2025-06-11
ER

PT J
AU Ouyang, R
   Zhao, XQ
   Zhang, RP
   Yang, J
   Li, SY
   Deng, DH
AF Ouyang, Rong
   Zhao, Xiaoqin
   Zhang, Rongping
   Yang, Jing
   Li, Siyin
   Deng, Daihua
TI FGF21 attenuates high uric acid-induced endoplasmic reticulum stress,
   inflammation and vascular endothelial cell dysfunction by activating
   Sirt1
SO MOLECULAR MEDICINE REPORTS
LA English
DT Article
DE uric acid; hyperuricemia; fibroblast growth factor 21; sirtuin 1
ID GROWTH-FACTOR 21; NLRP3 INFLAMMASOME; EXPRESSION; HYPERURICEMIA
AB Uric acid (UA) is the final oxidation product of purine metabolism. Hyperuricemia has been previously reported to contribute to vascular endothelial dysfunction and the development of cardiovascular diseases, metabolic syndrome and chronic kidney diseases. In addition, it has been reported that fibroblast growth factor 21 (FGF21) can exert regulatory effects on UA-induced lipid accumulation. Therefore, the present study aimed to investigate the possible role of FGF21 in HUVEC cell injury induced by UA. The study used UA to induce HUVEC cell injury, inhibited sirtuin 1 (Sirt1) expression using EX527 and overexpressed FGF21 by transfection. Subsequently, reverse transcription-quantitative PCR was performed to measure the mRNA expression levels of FGF21, Sirt1 and inflammatory cytokines TNF-alpha, IL-1 beta and IL-6, whereas western blotting was performed to measure their corresponding protein expression levels including FGF21, Sirt1, NLR family pyrin domain containing 3, pro-caspase1, apoptosis-associated speck-like protein containing a CARD, activating transcription factor 4, C/EBP homologous protein and eukaryotic initiation factor 2. Furthermore, dichloro-dihydro-fluorescein diacetate staining was performed to measure intracellular reactive oxygen species (ROS) generation in HUVECs. The levels of ROS and nitric oxide were also quantified using commercial assay kits. The results demonstrated that overexpression of FGF21 significantly inhibited UA treatment-induced endoplasmic reticulum (ER) stress, inflammation and oxidative stress in HUVECs. Furthermore, overexpression of FGF21 significantly activated Sirt1. The sirt1 inhibitor, EX527, significantly abrogated the suppressive effects of FGF21 overexpression on ER stress, inflammation and oxidative stress in UA-stimulated HUVECs. To conclude, results of the present study suggested that FGF21 may attenuate UA-induced ER stress, inflammation and vascular endothelial cell dysfunction by activating Sirt1. Therefore, FGF21 may be a potential effective target for the future treatment of vascular endothelial cell dysfunction.
C1 [Ouyang, Rong; Zhao, Xiaoqin; Zhang, Rongping] Nantong Univ, Dept Endocrinol, Affiliated Hosp, Nantong, Jiangsu 226001, Peoples R China.
   [Yang, Jing; Li, Siyin; Deng, Daihua] Mianyang Cent Hosp, Dept Rheumatol, 12 Changjia Lane, Mianyang 621000, Sichuan, Peoples R China.
C3 Nantong University
RP Deng, DH (corresponding author), Mianyang Cent Hosp, Dept Rheumatol, 12 Changjia Lane, Mianyang 621000, Sichuan, Peoples R China.
EM dengdaihua06@163.com
RI Ouyang, Rongzhen/HJB-1344-2022
FU Scientific Research Fund of Sichuan Health and Health Committee
   [19PJ114]
FX The present study was supported by the Scientific Research Fund of
   Sichuan Health and Health Committee (grant no. 19PJ114).
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NR 32
TC 18
Z9 19
U1 2
U2 6
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1791-2997
EI 1791-3004
J9 MOL MED REP
JI Mol. Med. Rep.
PD JAN
PY 2022
VL 25
IS 1
AR 35
DI 10.3892/mmr.2021.12551
PG 9
WC Oncology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Research & Experimental Medicine
GA XO5AT
UT WOS:000730198800001
PM 34850960
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Abdul-Aziz, SA
   Chong, ML
   McStea, M
   Wong, PL
   Ponnampalavanar, S
   Azwa, I
   Kamarulzaman, A
   Kamaruzzaman, SB
   Rajasuriar, R
AF Abdul-Aziz, S. A.
   Chong, M. L.
   McStea, M.
   Wong, P. L.
   Ponnampalavanar, S.
   Azwa, I
   Kamarulzaman, A.
   Kamaruzzaman, S. B.
   Rajasuriar, R.
TI Significant Psychosocial Influence in Frail People Living with HIV
   Independent of Frailty Instrument Used
SO JOURNAL OF FRAILTY & AGING
LA English
DT Article
DE Non-AIDS illness; non-communicable disease; frailty instrument; health
   domain; frailty characteristics
ID METABOLIC SYNDROME; INFECTED ADULTS; OLDER-PEOPLE; INDIVIDUALS; MIDDLE;
   PREVALENCE; MORTALITY; AGE; COMORBIDITIES; PREDICT
AB BACKGROUND: Antiretroviral therapy (ART) usage among people living with HIV (PLWH) has led to significant mortality declines and increasing lifespan. However, high incidence and early onset of aging-related conditions such as frailty, pose as a new threat to this population.
   OBJECTIVES: We aimed to characterize frailty by comparing health domains consisting of psychosocial, functional and physical deficits between frail PLWH and matched uninfected controls; identify associated risk factors and the impact on negative health outcomes including mortality risk score, quality of life, healthcare utilization, functional disability and history of falls among virally suppressed PLWH.
   DESIGN: Cross-sectional study
   SETTING: Infectious disease clinic in a tertiary institution
   PARTICIPANTS: Individuals aged >25 years, on ART > 12 months, not pregnant and without acute illness; multi-ethnic, Asian
   MEASUREMENTS: Frailty instruments included Frailty phenotype (FP), FRAIL scale (FS) and Frailty index (FI). FI health deficits were categorized into health domains (psychosocial, functional and physical) and used as standard comparator to characterize frailty. Health domains of frail PLWH were compared with frail matched, uninfected controls. Regression analyses were applied to explore associated risk factors and health-related frailty outcomes.
   RESULTS: We recruited 336 PLWH. Majority were male (83%), Chinese (71%) with CD4+ count 561 (397-738) cells/mu l. Frailty prevalence among PLWH were 7% (FP); 16% (FS) and 22% (FI). Proportions of psychosocial, functional, and physical domains were similarly distributed among frail PLWH measured by different frailty instruments. When compared with matched controls, psychosocial dominance was significant among the PLWH, but not in functional and physical domains. Identified frailty risk factors included poor nutritional status, higher CD4+ count nadir, depression, metabolic syndrome, higher highly sensitive C-reactive protein (hsCRP) and history of AIDS-defining illness (ADI). Frailty influenced the risk for negative health outcomes including increased mortality risk scores, poor quality of life (QOL), frequent healthcare utilization and increased functional disability (p<0.05).
   CONCLUSIONS: This study highlighted the importance of psychosocial influence in the development of frailty among treated PLWH in a multiethnic, Asian setting.
C1 [Abdul-Aziz, S. A.] Natl Univ Malaysia UKM, Fac Pharm, Kuala Lumpur, Malaysia.
   [Chong, M. L.; McStea, M.; Wong, P. L.; Ponnampalavanar, S.; Azwa, I; Kamarulzaman, A.; Kamaruzzaman, S. B.; Rajasuriar, R.] Univ Malaya, Ctr Excellence Res AIDS CERiA, Kuala Lumpur, Malaysia.
   [Chong, M. L.; Wong, P. L.; Ponnampalavanar, S.; Azwa, I; Kamarulzaman, A.; Kamaruzzaman, S. B.; Rajasuriar, R.] Univ Malaya, Fac Med, Dept Med, Kuala Lumpur 50603, Malaysia.
C3 Universiti Kebangsaan Malaysia; Universiti Malaya; Universiti Malaya
RP Rajasuriar, R (corresponding author), Univ Malaya, Fac Med, Dept Med, Kuala Lumpur 50603, Malaysia.
EM reena@um.edu.my
RI Azwa, Iskandar/N-9186-2017; McStea, Megan/M-7721-2019; Abdul Aziz,
   Siti/H-6527-2018; LA SRI PONNAMPALAVANAR, SASHEELA/B-9703-2010;
   Rajasuriar, Reena/B-9569-2010; KAMARULZAMAN, ADEEBA/B-5216-2010;
   Kamaruzzaman, Shahrul Bahyah/B-9728-2010
OI Rajasuriar, Reena/0000-0003-3756-0629; Raja Azwa, Raja
   Iskandar/0000-0003-1977-6709; Kamaruzzaman, Shahrul
   Bahyah/0000-0001-9880-3538; Mcstea, Megan/0000-0002-1241-7845; Sri La
   Sri Ponnampalavanar, Sasheela/0000-0002-4506-1304
FU High Impact Research Grant (HIR/MOHE) [H-20001-E000001,
   UM.0000099/HIR.C3]; University Malaya Postgraduate Research Fund
   [PG266-2016A]
FX This work was funded by the High Impact Research Grant (HIR/MOHE;
   H-20001-E000001, UM.0000099/HIR.C3) received by SK, AK, SP, and R.R; and
   the University Malaya Postgraduate Research Fund (PG266-2016A) received
   by RR and SA.
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NR 49
TC 2
Z9 4
U1 0
U2 3
PU SPRINGER BASEL AG
PI BASEL
PA PICASSOPLATZ 4, BASEL, 4052, SWITZERLAND
SN 2260-1341
EI 2273-4309
J9 J FRALITY AGING
JI J. Frality Aging
PD APR
PY 2022
VL 11
IS 2
BP 190
EP 198
DI 10.14283/jfa.2021.48
EA JAN 2022
PG 9
WC Geriatrics & Gerontology
WE Emerging Sources Citation Index (ESCI)
SC Geriatrics & Gerontology
GA 0Q5QK
UT WOS:000745586700001
PM 35441197
DA 2025-06-11
ER

PT J
AU Gordon, JL
   Rubinow, DR
   Watkins, L
   Hinderliter, AL
   Caughey, MC
   Girdler, SS
AF Gordon, Jennifer L.
   Rubinow, David R.
   Watkins, Lana
   Hinderliter, Alan L.
   Caughey, Melissa C.
   Girdler, Susan S.
TI The Effect of Perimenopausal Transdermal Estradiol and Micronized
   Progesterone on Markers of Risk for Arterial Disease
SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Article
DE stress reactivity; flow mediated dilation; baroreceptor sensitivity;
   metabolic risk; transdermal estradiol; intermittent micronized
   progesterone; menopause transition; early postmenopause
ID HORMONE REPLACEMENT THERAPY; CORONARY-HEART-DISEASE; PREMATURE OVARIAN
   FAILURE; CARDIAC VAGAL CONTROL; POSTMENOPAUSAL WOMEN; ENDOTHELIAL
   DYSFUNCTION; BLOOD-PRESSURE; HOT FLASHES; MENOPAUSAL TRANSITION;
   RATE-VARIABILITY
AB Background: The arterial effects of hormone therapy remain controversial. This study tested the effects of transdermal estradiol plus intermittent micronized progesterone (TE + IMP) in healthy perimenopausal and early postmenopausal women on several mechanisms involved in the pathophysiology of arterial disease.
   Methods: Healthy perimenopausal and early postmenopausal women, ages 45 to 60 years, were enrolled in this randomized, double-blind, placebo-controlled trial. Women were randomized to receive TE (0.1 mg/day) + IMP (200 mg/day for 12 days) or identical placebo patches and pills for 12 months. Outcomes included: change in stress reactivity composite z-score (combining inflammatory, cortisol, and hemodynamic responses to a standardized psychological laboratory stressor); flow-mediated dilation (FMD) of the brachial artery (an index of vascular endothelial function); baroreflex sensitivity; and metabolic risk (presence of the metabolic syndrome or insulin resistance), all assessed at baseline and at months 6 and 12.
   Results: Of 172 women enrolled, those assigned to TE + IMP tended to have higher resting baroreflex sensitivity than those assigned to placebo across the 6- and 12-month visits. Although treatment groups did not differ in terms of the other prespecified outcomes, a significant treatment-by-age interaction was found for FMD and stress reactivity such that an age-related decrease in FMD and increase in stress reactivity were seen among women assigned to placebo but not those assigned to TE + IMP. Women on TE + IMP also had lower resting diastolic blood pressure, lower levels of low-density lipoprotein cholesterol, and higher baroreflex sensitivity during stress testing.
   Conclusions: TE + IMP tended to improve cardiac autonomic control and prevented age-related changes in stress reactivity and endothelial function among healthy perimenopausal and early postmenopausal women.
C1 [Gordon, Jennifer L.] Univ Regina, Dept Psychol, Regina, SK S4S 0A2, Canada.
   [Rubinow, David R.; Girdler, Susan S.] Univ N Carolina, Dept Psychiat, Chapel Hill, NC USA.
   [Watkins, Lana] Duke Univ, Dept Psychiat & Behav Sci, Durham, NC 27708 USA.
   [Hinderliter, Alan L.; Caughey, Melissa C.] Univ N Carolina, Dept Med, Chapel Hill, NC 27599 USA.
C3 University of Regina; University of North Carolina; University of North
   Carolina Chapel Hill; Duke University; University of North Carolina;
   University of North Carolina Chapel Hill
RP Girdler, SS (corresponding author), Univ N Carolina, Dept Psychiat, Sch Med, CB 7160,101 Manning Dr, Chapel Hill, NC 27599 USA.
EM Susan_Girdler@med.unc.edu
FU NIH [RO1-MH087619, R01-MH108690, UL1TR001111]; North Carolina
   Biotechnology Center [2013-IDG-1023]
FX This research was supported by NIH grants RO1-MH087619, R01-MH108690,
   and UL1TR001111, as well as North Carolina Biotechnology Center grant
   #2013-IDG-1023. Dr. Gordon also receives salary support from the
   Canadian Institutes of Health Research as a Tier II Canada Research
   Chair in the Biopsychosocial Determinants of Women's Mental Health.
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NR 89
TC 9
Z9 9
U1 1
U2 7
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0021-972X
EI 1945-7197
J9 J CLIN ENDOCR METAB
JI J. Clin. Endocrinol. Metab.
PD MAY
PY 2020
VL 105
IS 5
AR dgz262
DI 10.1210/clinem/dgz262
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism
GA LD3SA
UT WOS:000525951200044
PM 31838497
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Botteri, G
   Montori, M
   Gumà, A
   Pizarro, J
   Cedó, L
   Escolà-Gil, JC
   Li, D
   Barroso, E
   Palomer, X
   Kohan, AB
   Vázquez-Carrera, M
AF Botteri, Gaia
   Montori, Marta
   Guma, Anna
   Pizarro, Javier
   Cedo, Lidia
   Carles Escola-Gil, Joan
   Li, Diana
   Barroso, Emma
   Palomer, Xavier
   Kohan, Alison B.
   Vazquez-Carrera, Manuel
TI VLDL and apolipoprotein CIII induce ER stress and inflammation and
   attenuate insulin signalling via Toll-like receptor 2 in mouse skeletal
   muscle cells
SO DIABETOLOGIA
LA English
DT Article
DE AMPK; apoCIII; ERK1/2; TLR2; VLDL
ID ENDOPLASMIC-RETICULUM STRESS; APOC-III; IN-VIVO; METABOLIC SYNDROME;
   COACTIVATOR PGC-1; TRANSGENIC MICE; DOWN-REGULATION; KAPPA-B; C-III;
   RESISTANCE
AB Aim/hypothesis Here, our aim was to examine whether VLDL and apolipoprotein (apo) CIII induce endoplasmic reticulum ( ER) stress, inflammation and insulin resistance in skeletal muscle.
   Methods Studies were conducted in mouse C2C12 myotubes, isolated skeletal muscle and skeletal muscle from transgenic mice overexpressing apoCIII.
   Results C2C12 myotubes exposed to VLDL showed increased levels of ER stress and inflammatory markers whereas peroxisome proliferator-activated receptor gamma co-activator 1 alpha (PGC-1 alpha) and AMP-activated protein kinase (AMPK) levels were reduced and the insulin signalling pathway was attenuated. The effects of VLDL were also observed in isolated skeletal muscle incubated with VLDL. The changes caused by VLDL were dependent on extracellular signal-regulated kinase (ERK) 1/2 since they were prevented by the ERK1/2 inhibitor U0126 or by knockdown of this kinase by siRNA transfection. ApoCIII mimicked the effects of VLDL and its effects were also blocked by ERK1/2 inhibition, suggesting that this apolipoprotein was responsible for the effects of VLDL. Skeletal muscle from transgenic mice overexpressing apoCIII showed increased levels of some ER stress and inflammatory markers and increased phosphorylated ERK1/2 levels, whereas PGC-1a levels were reduced, confirming apoCIII effects in vivo. Finally, incubation of myotubes with a neutralising antibody against Toll-like receptor 2 abolished the effects of apoCIII on ER stress, inflammation and insulin resistance, indicating that the effects of apoCIII were mediated by this receptor.
   Conclusions/interpretation These results imply that elevated VLDL in diabetic states can contribute to the exacerbation of insulin resistance by activating ERK1/2 through Toll-like receptor 2.
C1 [Botteri, Gaia; Montori, Marta; Pizarro, Javier; Barroso, Emma; Palomer, Xavier; Vazquez-Carrera, Manuel] Univ Barcelona, IBUB, Fac Pharm & Food Sci, Pharmacol Unit,Dept Pharmacol Toxicol & Therapeut, Diagonal 643, E-08028 Barcelona, Spain.
   [Botteri, Gaia; Montori, Marta; Guma, Anna; Pizarro, Javier; Cedo, Lidia; Carles Escola-Gil, Joan; Barroso, Emma; Palomer, Xavier; Vazquez-Carrera, Manuel] Inst Salud Carlos III, Ctr Invest Biomed Red Diabet & Enfermedad Metab A, Barcelona, Spain.
   [Botteri, Gaia; Montori, Marta; Pizarro, Javier; Barroso, Emma; Palomer, Xavier; Vazquez-Carrera, Manuel] IR SJD, Barcelona, Spain.
   [Guma, Anna] Univ Barcelona, Dept Biochem & Mol Biol, Barcelona, Spain.
   [Guma, Anna] Univ Barcelona, IBUB, Barcelona, Spain.
   [Cedo, Lidia; Carles Escola-Gil, Joan] Inst Invest Biomed IIB St Pau, Barcelona, Spain.
   [Carles Escola-Gil, Joan] Autonomous Univ Barcelona, Dept Biochem & Mol Biol, Barcelona, Spain.
   [Li, Diana; Kohan, Alison B.] Univ Connecticut, Dept Nutr Sci, Storrs, CT USA.
C3 University of Barcelona; CIBER - Centro de Investigacion Biomedica en
   Red; CIBERDEM; Instituto de Salud Carlos III; University of Barcelona;
   University of Barcelona; Autonomous University of Barcelona; University
   of Connecticut
RP Vázquez-Carrera, M (corresponding author), Univ Barcelona, IBUB, Fac Pharm & Food Sci, Pharmacol Unit,Dept Pharmacol Toxicol & Therapeut, Diagonal 643, E-08028 Barcelona, Spain.; Vázquez-Carrera, M (corresponding author), Inst Salud Carlos III, Ctr Invest Biomed Red Diabet & Enfermedad Metab A, Barcelona, Spain.; Vázquez-Carrera, M (corresponding author), IR SJD, Barcelona, Spain.
EM mvazquezcarrera@ub.edu
RI Escolà-Gil, Joan Carles/H-9522-2014; Barroso, Emma/JXY-3878-2024;
   Montori Grau, Marta/ABE-3575-2021; Gumà, Anna/C-5165-2017;
   PIZARRO-DELGADO, JAVIER/E-7268-2012; Li, Diana/KRP-6271-2024; Barroso,
   Emma/G-9305-2018; Kohan, Alison/IAM-5468-2023; Vazquez-Carrera,
   Manuel/H-2612-2015; Cedo Gine, Lidia/ABG-1998-2020
OI PIZARRO-DELGADO, JAVIER/0000-0002-3735-844X; Barroso,
   Emma/0000-0003-4551-4825; Guma, Anna/0000-0001-9390-5252; Palomer,
   Xavier/0000-0001-7647-9984; Montori Grau, Marta/0000-0001-5707-5407;
   Kohan, Alison/0000-0003-3127-7283; Vazquez-Carrera,
   Manuel/0000-0001-7138-8207; Cedo Gine, Lidia/0000-0003-4354-3411;
   Escola-Gil, Joan Carles/0000-0001-9021-2485
FU Spanish Ministerio de Economia y Competitividad [SAF2012-30708,
   SAF2015-64146-R]; Generalitat de Catalunya [2014SGR-0013]; NIH NIDDK
   [DK101663]; USDA NIFA [11874590]; USDA NIFA Hatch Formula Funds
   [2015-31200-06009]; Instituto de Salud Carlos III grant [PI16-00139];
   European Union ERDF funds; CIBER de Diabetes y Enfermedades Metabolicas
   Asociadas (CIBERDEM) [CB07/08/0003]; FPI grant from the Spanish
   Ministerio de Economia y Competitividad
FX This study was partly supported by funds from the Spanish Ministerio de
   Economia y Competitividad (SAF2012-30708 and SAF2015-64146-R to MVC),
   the Generalitat de Catalunya (2014SGR-0013 to MVC), NIH NIDDK (DK101663
   to ABK), USDA NIFA (11874590 to ABK) and USDA NIFA Hatch Formula Funds
   (2015-31200-06009 to ABK), an Instituto de Salud Carlos III grant
   (PI16-00139 to JCE-G) and European Union ERDF funds. CIBER de Diabetes y
   Enfermedades Metabolicas Asociadas (CIBERDEM) is an Instituto de Salud
   Carlos III project (Grant CB07/08/0003 to MVC). GB was supported by an
   FPI grant from the Spanish Ministerio de Economia y Competitividad.
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Z9 34
U1 1
U2 15
PU SPRINGER
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BP 2262
EP 2273
DI 10.1007/s00125-017-4401-5
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA FJ0QS
UT WOS:000412414700018
PM 28835988
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Hatia, S
   Septembre-Malaterre, A
   Le Sage, F
   Badiou-Bénéteau, A
   Baret, P
   Payet, B
   d'hellencourt, CL
   Gonthier, MP
AF Hatia, S.
   Septembre-Malaterre, A.
   Le Sage, F.
   Badiou-Beneteau, A.
   Baret, P.
   Payet, B.
   d'hellencourt, C. Lefebvre
   Gonthier, M. P.
TI Evaluation of antioxidant properties of major dietary polyphenols and
   their protective effect on 3T3-L1 preadipocytes and red blood cells
   exposed to oxidative stress
SO FREE RADICAL RESEARCH
LA English
DT Article
DE obesity; oxidative stress; inflammation; dietary antioxidants;
   polyphenols
ID NECROSIS-FACTOR-ALPHA; INSULIN-RESISTANCE; ADIPOSE-TISSUE;
   CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; PHENOLIC-ACIDS;
   PRE-ADIPOCYTES; OBESITY; FLAVONOIDS; QUERCETIN
AB Obesity has been associated with a marked risk of metabolic diseases and requires therapeutic strategies. Changes in redox status with increased oxidative stress in adipose tissue have been linked with obesity-related disorders. Thus, the biological effect of antioxidants such as polyphenols is of high interest. We aimed to measure antioxidant capacities of 28 polyphenols representative of main dietary phenolic acids, flavonoids, stilbenes and curcuminoids. Then, 14 molecules were selected for the evaluation of their effect on 3T3-L1 preadipocytes and human red blood cells exposed to oxidative stress. Analysis of reducing and free radical-scavenging capacities of compounds revealed antioxidant properties related to their structure, with higher activities for flavonoids such as quercetin and epicatechin. Their effects on preadipocytes' viability also depended on their structure, dose and time of exposure. Interestingly, most of the compounds exhibited a protective effect on preadipocytes exposed to oxidative stress, by reversing H2O2-induced anti-proliferative action and reactive oxygen species production. Polyphenols also exerted an anti-inflammatory effect on preadipocytes exposed to H2O2 by reducing IL-6 secretion. Importantly, such antioxidant and anti-infl ammatory effects were observed in co-exposition (polyphenol and prooxidant during 24 h) or pretreatment (polyphenol during 24 h, then prooxidant for 24 h) conditions. Moreover, compounds protected erythrocytes from AAPH radical-induced lysis. Finally, these results led to demonstrate that antioxidant and anti-infl ammatory properties of polyphenols may depend on structure, dose, time of exposure and cell conditioning with oxidative stress. Such findings should be considered for a better understanding of polyphenols' benefits in strategies aiming to prevent obesity-related diseases.
C1 [Hatia, S.; Septembre-Malaterre, A.; Le Sage, F.; Badiou-Beneteau, A.; Baret, P.; d'hellencourt, C. Lefebvre; Gonthier, M. P.] Univ La Reunion, UFR Sante, Grp Etud Inflammat Chron & Obesite, EA 4516, F-97744 St Denis, France.
   [Payet, B.] Univ La Reunion, Dept Sci, Chem Lab Nat Subst & Food Sci EA 2212, F-97744 St Denis, France.
C3 University of La Reunion; University of La Reunion
RP Gonthier, MP (corresponding author), Univ La Reunion, UFR Sante, Grp Etud Inflammat Chron & Obesite, EA 4516, 15 Ave Rene Cassin,CS 92003, F-97744 St Denis, France.
EM marie-paule.gonthier@univ-reunion.fr
FU European Union; French Ministry of Education and Research; Region
   Reunion and the Federative Structure for Environment; Biodiversity and
   Health from the University of La Reunion
FX This work was supported by the European Union, the French Ministry of
   Education and Research, the Region Reunion and the Federative Structure
   for Environment, Biodiversity and Health from the University of La
   Reunion.
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NR 69
TC 53
Z9 56
U1 0
U2 25
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1071-5762
EI 1029-2470
J9 FREE RADICAL RES
JI Free Radic. Res.
PD APR
PY 2014
VL 48
IS 4
BP 387
EP 401
DI 10.3109/10715762.2013.879985
PG 15
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA AC6YL
UT WOS:000332672500001
PM 24393006
DA 2025-06-11
ER

PT J
AU Daryani, A
   Basu, S
   Becker, W
   Larsson, A
   Risérus, U
AF Daryani, Achraf
   Basu, Samar
   Becker, Wulf
   Larsson, Anders
   Riserus, Ulf
TI Antioxidant intake, oxidative stress and inflammation among immigrant
   women from the Middle East living in Sweden:: Associations with
   cardiovascular risk factors
SO NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
LA English
DT Article
DE antioxidant intake; oxidative stress; inflammation; C-reactive protein;
   isoprostanes; cardiovascular risk factors; immigrants; middle east
ID C-REACTIVE PROTEIN; CORONARY-HEART-DISEASE; CONJUGATED LINOLEIC-ACID;
   BODY-MASS INDEX; VITAMIN-E; METABOLIC SYNDROME; LIPID-PEROXIDATION;
   INSULIN-RESISTANCE; DIABETES-MELLITUS; 8-ISO-PROSTAGLANDIN F2-ALPHA
AB Background and aims: Immigrant women from the Middle East have higher cardiovascular risk compared to native women. Whether low antioxidant intake, oxidative stress or inflammation contributes to risk is unknown. In a cross-sectional study of 157 randomly selected foreign-born women (Iranian and Turkish) and native women living in Sweden, we investigated antioxidant status, oxidative stress (F-2-isoprostanes) and systemic inflammation (plasma high sensitive C-reactive protein; CRP) markers. We also investigated relationships between F2-isoprostanes, CRP and cardiovascular risk factors.
   Methods and result: Dietary intake was assessed using 24-h dietary recalls repeated four times. Micronutrient intake was not consistently different between groups. Serum a-tocopherol, but not gamma-tocopherot levels, was tower in Turkish vs. Swedish women (P < 0.05). Turkish women had the highest F-2-isoprostane levels (P < 0.05 vs. Iranian women) and CRP levels (P < 0.01 vs. Swedish women and P = 0.05 vs. Iranian women). In immigrants (n = 97), F-2-isoprostanes correlated positively to insulin levels (r = 0.31, P < 0.01), and CRP was correlated to obesity and several cardiovascular risk factors (r-values >0.21, P values <0.05).
   Conclusion: The rote of antioxidant status is unclear, whereas signs of oxidative stress and inflammation are evident in immigrant women from Middle East, especially Turkish women. Oxidative stress and low-grade inflammation might contribute to the higher cardiovascular risk previously observed in immigrant women. Further larger studies adjusting for more potential confounders are motivated to confirm these results. (c) 2006 Elsevier B.V. All rights reserved.
C1 [Daryani, Achraf; Basu, Samar; Riserus, Ulf] Uppsala Univ, Dept Publ Hlth & Caring Sci, S-75185 Uppsala, Sweden.
   [Daryani, Achraf] Dept Domest Sci, Uppsala, Sweden.
   [Becker, Wulf] Informat & Nutr Dept, Swedish Natl Food Adm, Uppsala, Sweden.
   [Larsson, Anders] Uppsala Univ, Fac Med, Dept Med Sci, Sect Clin Chem, S-75185 Uppsala, Sweden.
C3 Uppsala University; Uppsala University
RP Daryani, A (corresponding author), Uppsala Univ, Dept Publ Hlth & Caring Sci, Uppsala Sci Pk, S-75185 Uppsala, Sweden.
EM achraf.daryani@pubcare.uu.se
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NR 64
TC 16
Z9 17
U1 0
U2 3
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0939-4753
EI 1590-3729
J9 NUTR METAB CARDIOVAS
JI Nutr. Metab. Carbiovasc. Dis.
PD DEC
PY 2007
VL 17
IS 10
BP 748
EP 756
DI 10.1016/j.numecd.2006.07.011
PG 9
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism; Nutrition
   & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism;
   Nutrition & Dietetics
GA 252QI
UT WOS:000252460900008
PM 17145175
DA 2025-06-11
ER

PT J
AU Grycuk, L
   Gordon, G
   Gaughran, F
   Campbell, IC
   Schmidt, U
AF Grycuk, Luiza
   Gordon, Gemma
   Gaughran, Fiona
   Campbell, Iain C.
   Schmidt, Ulrike
TI Effects of Transcranial Direct Current Stimulation (tDCS) and Approach
   Bias Modification (ABM) training on food cravings in people taking
   antipsychotic medication
SO TRIALS
LA English
DT Article
DE Schizophrenia; Weight gain; Transcranial direct current stimulation;
   Approach bias modification training
ID INDUCED WEIGHT-GAIN; PREFRONTAL CORTEX; CLINICAL-TRIAL; CLOZAPINE;
   SCHIZOPHRENIA; ABNORMALITIES; INTERVENTIONS; METAANALYSIS; MECHANISMS;
   DEPRESSION
AB Background Antipsychotic drug-induced weight gain puts individuals with schizophrenia at increased cardiometabolic risk. As a potential intervention for this problem, we describe the theoretical background and a protocol for a feasibility randomised controlled trial (RCT) of approach bias modification (ABM) training combined with real versus sham (placebo) transcranial direct current stimulation (tDCS). The primary aim of this trial is to obtain information that will guide decision making and protocol development in relation to a future large-scale RCT of ABM and tDCS in this group of participants. Second, the study will assess the preliminary efficacy of ABM + tDCS in reducing food cravings in people who take antipsychotic medication. Methods Thirty adults with a DSM-V diagnosis of schizophrenia or schizoaffective disorder treated with anti-psychotic medication will be randomly allocated to receive five sessions that will combine ABM and real or sham tDCS, in a parallel group design. In this feasibility study, a broad range of outcome variables will be examined. Measures will include food craving, psychopathology (e.g. symptoms of schizophrenia and depression), neuropsychological processes (such as attentional bias and impulsiveness), and the tolerability and acceptability of tDCS. The feasibility of conducting a large-scale RCT of ABM + tDCS and appropriateness of tDCS as a treatment for antipsychotic drug-induced weight gain will be evaluated by assessment of recruitment and retention rates, acceptability of random allocation, blinding success (allocation concealment), completion of treatment sessions and research assessments (baseline, post-treatment and follow-up). Discussion The effect sizes generated and other findings from this trial will inform a future large-scale RCT with respect to decisions on primary outcome measures and other aspects of protocol development. In addition, results from this study will provide a preliminary indication of the efficacy of ABM + tDCS treatment for antipsychotic drug-induced weight gain.
C1 [Grycuk, Luiza; Gordon, Gemma; Campbell, Iain C.; Schmidt, Ulrike] Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Psychol Med, Sect Eating Disorders, London SE5 8AF, England.
   [Gaughran, Fiona] Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Psychosis Studies, London SE5 8AF, England.
   [Gaughran, Fiona; Schmidt, Ulrike] South London & Maudsley NHS Fdn Trust, Maudsley Hosp, London SE5 8AZ, England.
C3 University of London; King's College London; University of London;
   King's College London; South London & Maudsley NHS Trust; Maudsley
   Hospital
RP Schmidt, U (corresponding author), Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Psychol Med, Sect Eating Disorders, London SE5 8AF, England.; Schmidt, U (corresponding author), South London & Maudsley NHS Fdn Trust, Maudsley Hosp, London SE5 8AZ, England.
EM ulrike.schmidt@kcl.ac.uk
RI Gaughran, Fiona/AAC-7160-2019; Gaughran, Fiona/H-5495-2011
OI Grycuk, Luiza Edyta/0000-0003-2821-314X; Gaughran,
   Fiona/0000-0001-7414-5569
FU National Institute for Health Research (NIHR) Biomedical Research Centre
   (BRC) at South London and Maudsley NHS Foundation Trust (SLaM); King's
   College London; National Institute for Health Research Collaboration for
   Leadership in Applied Health Research & Care Funding scheme; Maudsley
   Charity; BRC; NIHR
FX This work is supported by funding from the National Institute for Health
   Research (NIHR) Biomedical Research Centre (BRC) at South London and
   Maudsley NHS Foundation Trust (SLaM) and King's College London. LG, FG,
   IC and US receive salary support from the BRC. FG is, in part, funded by
   the National Institute for Health Research Collaboration for Leadership
   in Applied Health Research & Care Funding scheme and by the Maudsley
   Charity. GG is funded by a BRC PhD studentship. US is supported by an
   NIHR Senior Investigator Award. The funder was not involved in the study
   design and writing of this trial protocol paper, and will not be
   involved in the collection and analysis of data, nor the writing of the
   study report. The funders will not have ultimate authority over these
   activities. The views expressed are those of the author(s) and not
   necessarily those of the NHS, the NIHR or the Department of Health.
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NR 68
TC 3
Z9 3
U1 0
U2 16
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1745-6215
J9 TRIALS
JI Trials
PD MAR 6
PY 2020
VL 21
IS 1
AR 245
DI 10.1186/s13063-020-4112-y
PG 11
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA KU5XS
UT WOS:000519787700007
PM 32143725
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Lee, J
   Lee, JNFK.
   Lee, JJ
   Park, S
   Jung, S
   Lee, HJ
   Ha, JH
AF Lee, Jisu
   Lee, Jennifer K.
   Lee, Jae-Joon
   Park, Seohyun
   Jung, Sunyoon
   Lee, Hyun-Joo
   Ha, Jung-Heun
TI Partial Replacement of High-Fat Diet with Beef Tallow Attenuates
   Dyslipidemia and Endoplasmic Reticulum Stress in db/db
   Mice
SO JOURNAL OF MEDICINAL FOOD
LA English
DT Article
DE beef tallow; diabetes; dyslipidemia; endoplasmic reticulum stress; n-6;
   n-3 ratio
ID HEPATIC ER STRESS; INSULIN-RESISTANCE; CARDIOVASCULAR-DISEASE; METABOLIC
   SYNDROME; DIABETES-MELLITUS; AMPK ACTIVATION; VITAMIN-E; ACIDS;
   INFLAMMATION; HEALTH
AB High-fat diet (HFD) consumption is closely associated with an increased risk of metabolic syndromes (MetS), such as obesity, type 2 diabetes, and cardiovascular diseases (CVDs). Therefore, the consumption of alternative and functional fatty acids to replace saturated fatty acids and/or trans-fatty acids with polyunsaturated fatty acids has become an important dietary strategy for the prevention of MetS. Consumption of omega-3 fatty acids (n-3) reduces various physiological complications, including CVDs, nonalcoholic fatty liver disease, and insulin resistance, related to inflammatory responses. In this study, we investigated the partial replacement effects of HFD with beef tallow (BT) on dyslipidemia and endoplasmic reticulum (ER) stress in male db/db mice. The animals were grouped to one of four dietary intervention groups (n = 16 per group): (1) normal diet, (2) HFD, (3) HFD partially replaced with regular beef tallow (HFD+BT1), or (4) HFD partially replaced with beef tallow containing a relatively reduced omega-6 fatty acid (n-6)/n-3 ratio (HFD+BT2) than HFD+BT1. After 6 weeks of dietary intervention, 1 mg/kg of phosphate-buffered saline or tunicamycin (TM) was injected intraperitoneally. HFD+BT2 significantly suppressed the serum total cholesterol and non-high-density lipoprotein cholesterol levels more than HFD and HFD+BT1, and triglyceride levels in the epididymal adipose tissue (EAT) were remarkably decreased. Mice that received HFD+BT2 had elevated protein expressions of phospho-AMP-activated protein kinase (p-AMPK). Moreover, HFD+BT2 effectively inhibited ER stress in the liver and EAT. Consistent with our hypothesis, HFD+BT2 remarkably alleviated dyslipidemia and TM-inducible ER stress, while activating p-AMPK.
C1 [Lee, Jisu; Park, Seohyun; Jung, Sunyoon; Ha, Jung-Heun] Dankook Univ, Dept Food Sci & Nutr, Cheonan, South Korea.
   [Lee, Jennifer K.] Univ Florida, Food Sci & Human Nutr Dept, Gainesville, FL USA.
   [Lee, Jae-Joon] Chosun Univ, Dept Food & Nutr, Gwangju, South Korea.
   [Lee, Hyun-Joo] Hankyong Natl Univ, Dept Nutr & Culinary Sci, Ansung, South Korea.
   [Ha, Jung-Heun] Dankook Univ, Res Ctr Industrializat Nat Neutralizat, Yongin, South Korea.
   [Ha, Jung-Heun] Dankook Univ, Dept Food Sci & Nutr, Cheonan 31116, South Korea.
   [Lee, Hyun-Joo] Hankyong Natl Univ, Dept Nutr & Culinary Sci, Ansung 17579, South Korea.
C3 Dankook University; State University System of Florida; University of
   Florida; Chosun University; Hankyong National University; Dankook
   University; Dankook University; Hankyong National University
RP Ha, JH (corresponding author), Dankook Univ, Dept Food Sci & Nutr, Cheonan 31116, South Korea.; Lee, HJ (corresponding author), Hankyong Natl Univ, Dept Nutr & Culinary Sci, Ansung 17579, South Korea.
EM hjlee@hknu.ac.kr; ha@dankook.ac.kr
RI Lee, Joo-Hyun/ISA-7761-2023
OI HA, JUNG-HEUN/0000-0001-5282-531X; Lee, Jennifer/0000-0002-2282-2131
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NR 93
TC 13
Z9 13
U1 2
U2 15
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1096-620X
EI 1557-7600
J9 J MED FOOD
JI J. Med. Food
PD JUN 1
PY 2022
VL 25
IS 6
BP 660
EP 674
DI 10.1089/jmf.2022.K.0019
EA MAY 2022
PG 15
WC Chemistry, Medicinal; Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Food Science & Technology; Nutrition &
   Dietetics
GA 2F2GI
UT WOS:000800344600001
PM 35617705
DA 2025-06-11
ER

PT J
AU Muratsubaki, T
   Hattori, T
   Li, J
   Fukudo, S
   Munakata, M
AF Muratsubaki, Tomohiko
   Hattori, Tomomi
   Li, Jue
   Fukudo, Shin
   Munakata, Masanori
TI Relationship between Job Stress and Hypo-high-density Lipoproteinemia of
   Chinese Workers in Shanghai: The Rosai Karoshi Study
SO CHINESE MEDICAL JOURNAL
LA English
DT Article
DE Chinese Workers; Hypo-high-density Lipoproteinemia; Job Stress
ID CORONARY-HEART-DISEASE; RISK-FACTORS; METABOLIC SYNDROME; CARDIOVASCULAR
   RISK; INSULIN-RESISTANCE; STRAIN; MEN; DYSLIPIDEMIA; METAANALYSIS;
   ASSOCIATION
AB Background: Karoshi, or death due to overwork, has now become a serious social problem in China. Worsening of cardiovascular risks by stress might initiate karoshi. Many studies have examined the relationship between job stress and obesity, hypertension, and type 2 diabetes mellitus, but less evidence exists for dyslipidemia like hypo-high-density lipoproteinemia (hypo-HDL). The aim of this study was to investigate the relationship between job stress and hypo-HDL of Chinese workers in Shanghai.
   Methods: We studied 2219 Chinese workers in Shanghai, who participated in the Japan-China cooperative study for the prevention of karoshi. A questionnaire was administered to examine the lifestyle characteristics, job category, weekly working hours, and job stress. Job demand and job control were quantified using the National Institute for Occupational Safety and Health questionnaire. Modified job strain measure was defined by the combination of low job control and high demand. Hypo-HDL was defined as plasma high-density lipoprotein cholesterol concentration of <1.04 mmol/L (40 mg/dl). Multivariate logistic regression analysis was performed for hypo-HDL as a dependent variable.
   Results: Modified job strain was not related to hypo-HDL either in men or women. In men, multivariate adjusted odds ratio (OR) for having hypo-HDL was significantly higher in the lowest job control tertile compared with the highest job control tertile (OR = 1.39, 95% confidence interval [CI] 1.03-1.87, P = 0.034). In the same model, a similar trend was observed for women, but it did not reach a statistically significant level (OR = 1.51, 95% CI, 0.88-2.56, P = 0.132).
   Conclusion: A low level of job control but not modified job strain was significantly related to higher prevalence of hypo-HDL of Chinese workers in Shanghai.
C1 [Muratsubaki, Tomohiko; Fukudo, Shin] Tohoku Univ, Dept Behav Med, Grad Sch Med, Sendai, Miyagi 9808575, Japan.
   [Hattori, Tomomi; Munakata, Masanori] Tohoku Rosai Hosp, Res Ctr Lifestyle Related Dis, Sendai, Miyagi 9818563, Japan.
   [Li, Jue] Tongji Univ, Sch Med, Heart Lung & Blood Vessel Res Ctr, Shanghai 200092, Peoples R China.
   [Munakata, Masanori] Tohoku Rosai Hosp, Div Hypertens, Sendai, Miyagi 9818563, Japan.
C3 Tohoku University; Tongji University
RP Munakata, M (corresponding author), Tohoku Rosai Hosp, Div Hypertens, Aoba Ku, 3-21,Dainohara 4, Sendai, Miyagi 9818563, Japan.
EM munakata@tohokuh.rofuku.go.jp
RI Muratsubaki, Tomohiko/KPB-6283-2024; Fukudo, Shin/J-4813-2014; Li,
   Juexiu/KIB-6732-2024
OI Muratsubaki, Tomohiko/0009-0004-9567-1831
FU Japan Labor, Health, and Welfare Organization (Research Grant on
   Lifestyle-related Disease)
FX This study was supported by the grant from the Japan Labor, Health, and
   Welfare Organization (Research Grant on the Lifestyle-related Disease).
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NR 38
TC 8
Z9 14
U1 1
U2 21
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, 400059, INDIA
SN 0366-6999
J9 CHINESE MED J-PEKING
JI Chin. Med. J.
PD OCT 20
PY 2016
VL 129
IS 20
BP 2409
EP 2415
DI 10.4103/0366-6999.191750
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA EB0MD
UT WOS:000387037000003
PM 27748331
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Pung, YF
   Rocic, P
   Murphy, MP
   Smith, RAJ
   Hafemeister, J
   Ohanyan, V
   Guarini, G
   Yin, LY
   Chilian, WM
AF Pung, Yuh Fen
   Rocic, Petra
   Murphy, Michael P.
   Smith, Robin A. J.
   Hafemeister, Jennifer
   Ohanyan, Vahagn
   Guarini, Giacinta
   Yin, Liya
   Chilian, William M.
TI Resolution of Mitochondrial Oxidative Stress Rescues Coronary Collateral
   Growth in Zucker Obese Fatty Rats
SO ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
LA English
DT Article
DE collateral circulation; coronary circulation; obesity; oxidized lipids;
   reactive oxygen species
ID TARGETED ANTIOXIDANT MITOQ; ENDOTHELIAL DYSFUNCTION; SUPEROXIDE; HEART;
   DAMAGE; UBIQUINONE; DISEASES; OXIDASE; CELLS
AB Objective-We have previously found abrogated ischemia-induced coronary collateral growth in Zucker obese fatty (ZOF) rats compared with Zucker lean (ZLN) rats. Because ZOF rats have structural abnormalities in their mitochondria suggesting dysfunction and also show increased production of O-2(radical anion), we hypothesized that mitochondrial dysfunction caused by oxidative stress impairs coronary collateral growth in ZOF.
   Methods and Results-Increased levels of reactive oxygen species were observed in aortic endothelium and smooth muscle cells in ZOF rats compared with ZLN rats. Reactive oxygen species levels were decreased by the mitochondria-targeted antioxidants MitoQuinone (MQ) and MitoTempol (MT) as assessed by MitoSox Red and dihydroethidine staining. Lipid peroxides (a marker of oxidized lipids) were increased in ZOF by approximate to 47% compared with ZLN rats. The elevation in oxidative stress was accompanied by increased antioxidant enzymes, except glutathione peroxidase-1, and by increased uncoupling protein-2 in ZOF versus ZLN rats. In addition, elevated respiration rates were also observed in the obese compared with lean rats. Administration of MQ significantly normalized the metabolic profiles and reduced lipid peroxides in ZOF rats to the same level observed in lean rats. The protective effect of MQ also suppressed the induction of uncoupling protein-2 in the obese rats. Resolution of mitochondrial oxidative stress by MQ or MT restored coronary collateral growth to the same magnitude observed in ZLN rats in response to repetitive ischemia.
   Conclusion-We conclude that mitochondrial oxidative stress and dysfunction play a key role in disrupting coronary collateral growth in obesity and the metabolic syndrome, and elimination of the mitochondrial oxidative stress with MQ or MT rescues collateral growth. (Arterioscler Thromb Vasc Biol. 2012;32:325-334.)
C1 [Pung, Yuh Fen; Hafemeister, Jennifer; Ohanyan, Vahagn; Guarini, Giacinta; Yin, Liya; Chilian, William M.] NE Ohio Med Univ, Dept Integrat Med Sci, Rootstown, OH 44272 USA.
   [Rocic, Petra] Univ S Alabama, Dept Biochem & Mol Biol, Mobile, AL 36688 USA.
   [Murphy, Michael P.] MRC, Mitochondrial Biol Unit, Cambridge, England.
   [Smith, Robin A. J.] Univ Otago, Dept Chem, Dunedin, New Zealand.
C3 University System of Ohio; Northeast Ohio Medical University (NEOMED);
   University of South Alabama; University of Otago
RP Chilian, WM (corresponding author), NE Ohio Med Univ, Dept Integrat Med Sci, Rootstown, OH 44272 USA.
EM wchilian@neomed.edu
RI Guarini, Giacinta/J-7542-2016; Pung, Yuh Fen/E-8959-2016; Murphy,
   Michael/C-2120-2009
OI Pung, Yuh Fen/0000-0001-6195-3970; Rocic, Petra/0000-0002-5781-3075;
   Guarini, Giacinta/0000-0001-6451-6995; Murphy,
   Michael/0000-0003-1115-9618
FU National Institutes of Health [HL32788, HL83366, RC1HL100828]; American
   Heart Association [09POST2290021]; Direct For Social, Behav & Economic
   Scie; Division Of Behavioral and Cognitive Sci [0959438] Funding Source:
   National Science Foundation; American Heart Association (AHA)
   [09POST2290021] Funding Source: American Heart Association (AHA); MRC
   [MC_U105663142] Funding Source: UKRI
FX This work was supported by National Institutes of Health Grants HL32788,
   HL83366, and RC1HL100828 (to W. M. C.) and by American Heart Association
   Postdoctoral Fellowship 09POST2290021 (to Y.F.P.).
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NR 52
TC 54
Z9 62
U1 0
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1079-5642
EI 1524-4636
J9 ARTERIOSCL THROM VAS
JI Arterioscler. Thromb. Vasc. Biol.
PD FEB
PY 2012
VL 32
IS 2
BP 325
EP U365
DI 10.1161/ATVBAHA.111.241802
PG 12
WC Hematology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Hematology; Cardiovascular System & Cardiology
GA 879HV
UT WOS:000299321200024
PM 22155454
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Smith, SI
AF Smith, SI
TI PPAR-γ receptor agonists -: a review of their role in diabetic
   management in Trinidad and Tobago
SO MOLECULAR AND CELLULAR BIOCHEMISTRY
LA English
DT Article; Proceedings Paper
CT International Conference on Advances in Cardiovascular Research
CY MAR 04-08, 2002
CL TRINID & TOBAGO
SP Int Acad Cardiovasc Sci, Univ W Indies, Caribbean Acad Sci
DE beta-cell; insulin resistance; PPAR-gamma; thiazolidinediones
ID ACUTE MYOCARDIAL-INFARCTION; FREE FATTY-ACID; PROTEIN-KINASE-C;
   SEROTONIN TRANSPORTER GENE; IMPAIRED GLUCOSE-TOLERANCE;
   INSULIN-RESISTANCE; CARDIOVASCULAR-DISEASE; RISK-FACTOR; OXIDATIVE
   STRESS; GLYCEMIC CONTROL
AB The PPAR-gamma receptor agonists, as a relatively new and perhaps still not very widely used class of antidiabetic agent in the Caribbean and particularly the Trinidadian context, possess pharmacologic properties that certainly have been shown to have impact on many of the inflammatory, metabolic, biochemical and structural macrovascular aberrations that occur in the type 2 diabetic. Activation of PPAR( gamma) nuclear receptors regulates the transcription of insulin-responsive genes involved in the control of glucose production, transport, and utilization. PPAR(gamma)-responsive genes also participate in the regulation of fatty acid metabolism, an important contributory pathogenic factor in this subset of patients. The unique mode of action of this class of therapeutic agent addresses a range of anomalies occurring at the cellular and sub-cellular level that are injurious to the diabetic. My aim in addressing the issue of the potential impact of PPAR-gamma receptor agonists on cardiovascular disease (CVD) morbidity and mortality in the diabetic, is first, to seek to enhance both an awareness of, and greater familiarity among our own physicians, with this class of drug, and secondly, to effect a timely review of the recent literature as it relates to the tremendous possibilities for the potential clinical gains that might accrue from their use, in so far as this may serve to ameliorate the ravages of the CVD disease that all too tragically attends the type 2 diabetic, and more specifically those with the insulin resistance syndrome.
C1 Gen Hosp, San Fernando, Trinidad Tobago.
RP 20 Herrera St, San Fernando, Trinidad Tobago.
EM sismith@carib-link.net
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NR 121
TC 3
Z9 4
U1 0
U2 1
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0300-8177
EI 1573-4919
J9 MOL CELL BIOCHEM
JI Mol. Cell. Biochem.
PD AUG
PY 2004
VL 263
IS 1
BP 189
EP 210
DI 10.1023/B:MCBI.0000041861.79585.4b
PG 22
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Cell Biology
GA 854QK
UT WOS:000223918200020
PM 15524180
DA 2025-06-11
ER

PT J
AU Sargeant, LA
   Khaw, KT
   Bingham, S
   Day, NE
   Luben, RN
   Oakes, S
   Welch, A
   Wareham, NJ
AF Sargeant, LA
   Khaw, KT
   Bingham, S
   Day, NE
   Luben, RN
   Oakes, S
   Welch, A
   Wareham, NJ
TI Cigarette smoking and glycaemia: the EPIC-Norfolk Study
SO INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
LA English
DT Article
DE smoking; glycosylated haemoglobin; diabetes mellitus; epidemiology
ID INSULIN-RESISTANCE SYNDROME; MIDDLE-AGED MEN; DIABETES-MELLITUS;
   OXIDATIVE STRESS; GLUCOSE-TOLERANCE; RISK-FACTORS; BODY-FAT; SMOKERS;
   POPULATION; HEMOGLOBIN
AB Background Previous prospective studies have suggested that cigarette smoking may be associated with an increased risk of type 2 diabetes, but the possibility of confounding, particularly by dietary factors has not been fully examined.
   Methods Cross-sectional analysis of the association between cigarette smoking and HbA(1C), a marker of long-term glucose homeostasis in 2704 men and 3385 women, aged 45-74 years who were recruited to a population-based study of diet and chronic disease.
   Results Twelve per cent of men and 11% of women reported being current smokers. Mean HbA(1C) was lowest in never smokers, intermediate in former smokers and highest in current smokers. There was a dose-response relationship between HbA(1C) levels and number of cigarettes smoked per day and a positive association with total smoking exposure as measured by pack-years. The unadjusted increase in HbA(1C) for 20 pack-years of smoking was 0.12% (95% CI:0.09-0.16) in men and 0.12% (95% CI:0.08-0.17) in women. After adjustment for possible confounders including dietary variables, the values were 0.08% (95% CI:0.040.12) and 0.07% (95% CI:0.02-0.12) for men and women, respectively. Mean HbA(1C) was inversely related to time since quitting smoking to men.
   Conclusions These results add support to the hypothesis that smoking has long-term effects on glucose homeostasis, an association that cannot be explained by confounding by dietary factors as measured in this study.
C1 Univ Cambridge, Inst Publ Hlth, Dept Publ Hlth & Primary Care, Cambridge CB2 2SR, England.
   MRC, Dunn Human Nutr Unit, Cambridge CB2 2DH, England.
C3 University of Cambridge; UK Research & Innovation (UKRI); Medical
   Research Council UK (MRC); MRC Human Nutrition Research
RP Wareham, NJ (corresponding author), Univ Cambridge, Inst Publ Hlth, Dept Publ Hlth & Primary Care, Robinson Way, Cambridge CB2 2SR, England.
RI Luben, Robert/KIC-1257-2024; Khaw, Kay-Tee/AAZ-3209-2021; Welch,
   Ailsa/A-4850-2008; Timpson, Nicholas/O-7548-2015
OI Luben, Robert/0000-0002-5088-6343
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NR 42
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U1 0
U2 1
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0300-5771
J9 INT J EPIDEMIOL
JI Int. J. Epidemiol.
PD JUN
PY 2001
VL 30
IS 3
BP 547
EP 554
DI 10.1093/ije/30.3.547
PG 8
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA 449TM
UT WOS:000169703300028
PM 11416081
OA Bronze
DA 2025-06-11
ER

PT J
AU Ghasemzadeh, N
   Patel, RS
   Eapen, DJ
   Veledar, E
   Al Kassem, H
   Manocha, P
   Khayata, M
   Zafari, AM
   Sperling, L
   Jones, DP
   Quyyumi, AA
AF Ghasemzadeh, Nima
   Patel, Riyaz S.
   Eapen, Danny J.
   Veledar, Emir
   Al Kassem, Hatem
   Manocha, Pankaj
   Khayata, Mohamed
   Zafari, A. Maziar
   Sperling, Laurence
   Jones, Dean P.
   Quyyumi, Arshed A.
TI Oxidative Stress Is Associated With Increased Pulmonary Artery Systolic
   Pressure in Humans
SO HYPERTENSION
LA English
DT Article
DE cystine; hypertension, pulmonary; oxidative stress
ID TRANSGENIC (MREN2)27 RAT; HUMAN PLASMA; DOPPLER-ECHOCARDIOGRAPHY;
   ANTIOXIDANT THERAPY; LIPID-PEROXIDATION; METABOLIC SYNDROME;
   HEALTHY-ADULTS; REDOX STATE; HYPERTENSION; SUPEROXIDE
AB Oxidative stress contributes to the development of pulmonary hypertension in experimental models, but this association in humans is unknown. We investigated the relationship between pulmonary artery systolic pressure measured by echocardiography and plasma aminothiol oxidative stress markers, with the hypothesis that oxidative stress will be higher in those with pulmonary hypertension. A group of 347 patients aged 65 +/- 12 years from the Emory Cardiovascular Biobank underwent echocardiographic assessment of left ventricular ejection fraction and pulmonary artery systolic pressure. Plasma aminothiols, cysteine, its oxidized form, cystine, glutathione, and its oxidized disulphide were measured and the redox potentials (E-h) of cysteine/cystine and glutathione/oxidized glutathione couples were calculated. Non-normally distributed variables were log transformed (L-n). Univariate predictors of pulmonary artery systolic pressure included age (P<0.001), sex (P=0.002), mitral regurgitation (P<0.001), left ventricular ejection fraction (P<0.001), left atrial size (P<0.001), diabetes mellitus (P=0.03), plasma L-n cystine (beta=9.53; P<0.001), L-n glutathione (beta=-5.4; P=0.002), and E-h glutathione (beta=0.21; P=0.001). A multivariate linear regression model adjusting for all confounding variables demonstrated that L-n cystine (beta=6.56; P=0.007), mitral regurgitation (beta=4.52; P<0.001), statin use (beta=-3.39; P=0.03), left ventricular ejection fraction (beta=-0.26; P=0.003), and age (beta=0.17; P=0.003) were independent predictors of pulmonary artery systolic pressure. For each 1% increase in plasma cystine, pulmonary artery systolic pressure increased by 16%. This association persisted in the subgroup with preserved left ventricular ejection fraction (>= 50%) and no significant mitral regurgitation. Whether treatment of oxidative stress will improve pulmonary hypertension requires further study.
C1 [Ghasemzadeh, Nima; Eapen, Danny J.; Al Kassem, Hatem; Manocha, Pankaj; Khayata, Mohamed; Zafari, A. Maziar; Sperling, Laurence; Jones, Dean P.; Quyyumi, Arshed A.] Emory Univ, Sch Med, Dept Med, Atlanta, GA USA.
   [Patel, Riyaz S.] UCL, Inst Cardiovasc Sci, London, England.
   [Veledar, Emir] Rollins Sch Publ Hlth, Dept Epidemiol, Atlanta, GA USA.
   [Veledar, Emir] Florida Int Univ, Dept Biostat, Miami, FL 33199 USA.
   [Zafari, A. Maziar] Atlanta Vet Affairs Med Ctr, Dept Med, Decatur, GA USA.
C3 Emory University; University of London; University College London; Emory
   University; Rollins School Public Health; State University System of
   Florida; Florida International University; US Department of Veterans
   Affairs; Veterans Health Administration (VHA); Atlanta VA Health Care
   System
RP Quyyumi, AA (corresponding author), Emory Clin Cardiovasc Res Inst, Div Cardiol, 1462 Clifton Rd NE,Suite 507, Atlanta, GA 30322 USA.
EM aquyyum@emory.edu
RI Zafari, Abarmard/GRF-6849-2022; Veledar, Emir/L-6637-2019; Khayata,
   Mohamed/I-5288-2015
OI KHAYATA, MOHAMED/0000-0001-8116-4311; Veledar, Emir/0000-0002-3831-5433
FU Robert W. Woodruff Health Sciences Center Fund (Atlanta, GA); Emory
   Heart and Vascular Center (Atlanta, GA); Katz Family Foundation;
   National Institutes of Health [UL1 RR02008]
FX Funding for collection and management of samples was received from the
   Robert W. Woodruff Health Sciences Center Fund (Atlanta, GA), Emory
   Heart and Vascular Center (Atlanta, GA), Katz Family Foundation, and in
   part from National Institutes of Health grant UL1 RR02008. Sample
   measurements were performed at the Emory Clinical Biomarkers Laboratory.
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NR 49
TC 38
Z9 39
U1 0
U2 8
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0194-911X
EI 1524-4563
J9 HYPERTENSION
JI Hypertension
PD JUN
PY 2014
VL 63
IS 6
BP 1270
EP 1275
DI 10.1161/HYPERTENSIONAHA.113.02360
PG 6
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA AG5XL
UT WOS:000335491900163
PM 24614216
OA Green Submitted, Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Teimouri, N
   Kazemizadeh, V
AF Teimouri, Nastaran
   Kazemizadeh, Vahid
TI Endurance Training Alleviates Metabolic-Associated Fatty-Liver Disease
   (MAFLD)-Related Testicular Impairments via Endoplasmic Reticulum Stress
   Regulation
SO JOURNAL OF CLINICAL LABORATORY ANALYSIS
LA English
DT Article; Early Access
DE endoplasmic reticulum stress; fatty liver; male infertility; metabolic
   syndrome; physical activity
ID HORMONE-BINDING GLOBULIN; OXIDATIVE STRESS; AEROBIC EXERCISE;
   TESTOSTERONE; OBESITY; MANAGEMENT; MARKERS; PROTEIN; HEALTH; SPLEEN
AB BackgroundMetabolic-associated fatty liver disease (MAFLD), the most prevalent liver disorder globally, affects 20%-40% of the population and presents significant health challenges. Studies link MAFLD to male reproductive dysfunction, highlighting the need for effective interventions. This study investigates the impact of MAFLD on testicular function and evaluates the protective role of endurance training, with a focus on the GRP78-IRE-1 alpha-ATF6 signaling pathway.MethodsForty-four rats were allocated into two dietary groups (n = 22 each): a standard diet control group (C) and a high-fat diet supplemented with fructose water group (FL). After 17 weeks, histological analysis confirmed MAFLD development in the FL group, while the control group showed no pathological changes. Each dietary group was further subdivided into sedentary and endurance-trained (T) subgroups (n = 10 per subgroup), resulting in four experimental groups: C, C + T, FL + T, and FL. At the end of the research, thyroid stimulating hormone (TSH), sex hormones (testosterone), tumor necrosis factor-alpha (TNF-a) as well as GRP78, IRE-1 alpha, and AFT6 expression were assessed.ResultsOur results indicated that MAFLD led to significant weight gain, disrupted serum levels of thyroid-stimulating hormone, and impaired sex hormone profile. Additionally, MAFLD triggered ER stress, evidenced by dysregulated expression of genes in the GRP78-IRE-1 alpha-ATF6 pathway. Remarkably, endurance training mitigated these adverse effects by normalizing hormonal profiles and restoring the expression of ER stress-related genes. These findings highlight the critical role of ER stress in MAFLD-induced male reproductive dysfunction.ConclusionOverall, the present study suggests endurance training as a promising treatment strategy for addressing MAFLD and its associated reproductive complications.
C1 [Teimouri, Nastaran] Kermanshah Univ Med Sci, Imam Reza Hosp, Clin Res Dev Ctr, Kermanshah, Iran.
   [Kazemizadeh, Vahid] Kermanshah Univ Med Sci, Hlth Policy & Promot Inst, Cardiovasc Res Ctr, Kermanshah, Iran.
   [Kazemizadeh, Vahid] Razi Univ, Fac Sport Sci, Dept Sport Physiol, Kermanshah, Iran.
C3 Kermanshah University of Medical Sciences; Kermanshah University of
   Medical Sciences; Razi University
RP Kazemizadeh, V (corresponding author), Kermanshah Univ Med Sci, Hlth Policy & Promot Inst, Cardiovasc Res Ctr, Kermanshah, Iran.; Kazemizadeh, V (corresponding author), Razi Univ, Fac Sport Sci, Dept Sport Physiol, Kermanshah, Iran.
EM vahid13k17@gmail.com
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NR 83
TC 0
Z9 0
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 0887-8013
EI 1098-2825
J9 J CLIN LAB ANAL
JI J. Clin. Lab. Anal.
PD 2025 MAY 1
PY 2025
DI 10.1002/jcla.70042
EA MAY 2025
PG 10
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA 2DF0A
UT WOS:001479859500001
PM 40313012
DA 2025-06-11
ER

PT J
AU Ivask, M
   Volke, V
   Raasmaja, A
   Koks, S
AF Ivask, Marilin
   Volke, Vallo
   Raasmaja, Atso
   Koks, Sulev
TI High-fat diet associated sensitization to metabolic stress in Wfs
   1 heterozygous mice
SO MOLECULAR GENETICS AND METABOLISM
LA English
DT Article
DE Wfs1; High fat diet; Insulin; ER stress
ID ENDOPLASMIC-RETICULUM STRESS; UNFOLDED PROTEIN RESPONSE; GENOME-WIDE
   ASSOCIATION; WOLFRAM-SYNDROME; INSULIN-SECRETION; BETA-CELLS; GENE;
   HOMEOSTASIS; VARIANTS; DELETION
AB Wolfram syndrome is a rare autosomal recessive disorder caused by mutations in the wolframin ER transmembrane glycoprotein (WFS1) gene and characterized by diabetes mellitus, diabetes insipidus, optic atrophy and deafness. In experimental models the homozygous Wfs1 mutant mice have a full penetrance and clearly expressed phenotype, whereas heterozygous mutants have a less-pronounced phenotype between the wild type and homozygous mutant mice. Heterozygous WFS1 mutations have been shown to be significant risk factors for diabetes and metabolic disorders in humans. In the present study we analyzed the response of heterozygous Wfs1 mice to high fat diet (HFD) by exploring potential outcomes and molecular changes induced by this challenge. The HFD treatment increased the body weight (BW) similarly both in Wfs1 wild-type (WT) and heterozygous (HZ) mice, and therefore HFD also prevented the impaired BW gain found in Wfs1 mutant mice. In Wfs1HZ mutant mice, HFD impaired the normalized insulin secretion and the expression of ER stress genes in isolated pancreatic islets. These results suggest that Wfs1HZ mice have a decreased insulin response and pronounced cellular stress response due to a higher sensitivity to HFD as hypothesized. In Wfs1HZ mice, HFD increased the expression of Ire1 alpha and Chop in pancreas and decreased that of Ire1 alpha and Atf4 in liver. The present study shows that HFD can disturb insulin function with an increased ER stress in Wfs1HZ mice and only one functional Wfs1 gene copy is not sufficient to compensate this challenge. In conclusion, our study indicates that quantitative Wfs1 gene deficiency is sufficient to predispose the carriers of single functional Wfs1 copy to diabetes and metabolic syndrome and makes them susceptible to the environmental challenges such as HFD. (c) 2021 Elsevier Inc. All rights reserved.
C1 [Ivask, Marilin; Volke, Vallo; Raasmaja, Atso] Univ Tartu, Inst Biomed & Translat Med, Dept Pathophysiol, Tartu, Estonia.
   [Raasmaja, Atso] Univ Helsinki, Fac Pharm, Div Pharmacol & Pharmacotherapy, Helsinki, Finland.
   [Volke, Vallo] Tartu Univ Hosp, Endocrinol Unit, Tartu, Estonia.
   [Koks, Sulev] Murdodt Univ, Ctr Mol Med & Innovat Therapeut, Perth, WA, Australia.
   [Koks, Sulev] Perron Inst Neurol & Translat Sci, Perth, WA, Australia.
C3 University of Tartu; University of Helsinki; Murdoch University; Perron
   Institute for Neurological & Translational Science
RP Raasmaja, A (corresponding author), Univ Tartu, Inst Biomed & Translat Med, Dept Pathophysiol, Tartu, Estonia.
EM atso.raasmaja@helsinki.fi
RI Volke, Vallo/AAL-9552-2020; Koks, Sulev/HSA-8160-2023; Ivask,
   Marilin/M-1601-2016; /H-3655-2015
OI Ivask, Marilin/0000-0002-3512-5052; /0000-0001-6087-6643
FU European Union's Horizon 2020 research and innovation program [668989];
   Estonian Ministry of Education [IUT20-46]; Estonian Archimedes
   Foundation [IUT20-46]
FX This work was supported by the European Union's Horizon 2020 research
   and innovation program under grant agreement No 668989 (Transgeno), and
   by the Institutional Research Funding IUT20-46 of the Estonian Ministry
   of Education, and by the Estonian Archimedes Foundation.
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NR 49
TC 7
Z9 7
U1 0
U2 3
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 1096-7192
EI 1096-7206
J9 MOL GENET METAB
JI Mol. Genet. Metab.
PD SEP-OCT
PY 2021
VL 134
IS 1-2
BP 203
EP 211
DI 10.1016/j.ymgme.2021.07.002
EA OCT 2021
PG 9
WC Endocrinology & Metabolism; Genetics & Heredity; Medicine, Research &
   Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Genetics & Heredity; Research & Experimental
   Medicine
GA WR8BK
UT WOS:000714720400025
PM 34312071
DA 2025-06-11
ER

PT J
AU Son, M
   Oh, S
   Lee, HS
   Chung, DM
   Jang, JT
   Jeon, YJ
   Choi, CH
   Park, KY
   Son, KH
   Byun, K
AF Son, Myeongjoo
   Oh, Seyeon
   Lee, Hye Sun
   Chung, Dong-Min
   Jang, Ji Tae
   Jeon, You-Jin
   Choi, Chang Hu
   Park, Kook Yang
   Son, Kuk Hui
   Byun, Kyunghee
TI Ecklonia Cava Extract Attenuates Endothelial Cell Dysfunction by
   Modulation of Inflammation and Brown Adipocyte Function in Perivascular
   Fat Tissue
SO NUTRIENTS
LA English
DT Article
DE obesity; Ecklonia cava; perivascular fat tissue; brown adipocyte;
   endothelial cell dysfunction; endoplasmic reticulum stress; inflammation
ID NITRIC-OXIDE SYNTHASE; ENDOPLASMIC-RETICULUM STRESS; ACTIVATED
   PROTEIN-KINASE; VASCULAR SMOOTH-MUSCLE; WHITE ADIPOSE-TISSUE; METABOLIC
   SYNDROME; OBESITY; SIRT1; ADIPONECTIN; ALPHA
AB It is well known that perivascular fat tissue (PVAT) dysfunction can induce endothelial cell (EC) dysfunction, an event which is related with various cardiovascular diseases. In this study, we evaluated whether Ecklonia cava extract (ECE) and pyrogallol-phloroglucinol-6,6-bieckol (PPB), one component of ECE, could attenuate EC dysfunction by modulating diet-induced PVAT dysfunction mediated by inflammation and ER stress. A high fat diet (HFD) led to an increase in the number and size of white adipocytes in PVAT; PPB and ECE attenuated those increases. Additionally, ECE and PPB attenuated: (i) an increase in the number of M1 macrophages and the expression level of monocyte chemoattractant protein-1 (MCP-1), both of which are related to increases in macrophage infiltration and induction of inflammation in PVAT, and (ii) the expression of pro-inflammatory cytokines (e.g., tumor necrosis factor-alpha (TNF-alpha) and interleukin (IL)-6, chemerin) in PVAT which led to vasoconstriction. Furthermore, ECE and PPB: (i) enhanced the expression of adiponectin and IL-10 which had anti-inflammatory and vasodilator effects, (ii) decreased HFD-induced endoplasmic reticulum (ER) stress and (iii) attenuated the ER stress mediated reduction in sirtuin type 1 (Sirt1) and peroxisome proliferator-activated receptor gamma (PPAR gamma) expression. Protective effects against decreased Sirt1 and PPAR gamma expression led to the restoration of uncoupling protein-1 (UCP-1) expression and the browning process in PVAT. PPB or ECE attenuated endothelial dysfunction by enhancing the pAMPK-PI3K-peNOS pathway and reducing the expression of endothelin-1 (ET-1). In conclusion, PPB and ECE attenuated PVAT dysfunction and subsequent endothelial dysfunction by: (i) decreasing inflammation and ER stress, and (ii) modulating brown adipocyte function.
C1 [Son, Myeongjoo; Byun, Kyunghee] Gachon Univ, Dept Anat & Cell Biol, Coll Med, Incheon 21936, South Korea.
   [Son, Myeongjoo; Oh, Seyeon; Lee, Hye Sun; Byun, Kyunghee] Gachon Univ, Grad Sch, Coll Med, Funct Cellular Networks Lab,Dept Med, Incheon 21999, South Korea.
   [Son, Myeongjoo; Oh, Seyeon; Lee, Hye Sun; Byun, Kyunghee] Gachon Univ, Lee Gil Ya Canc & Diabet Inst, Incheon 21999, South Korea.
   [Chung, Dong-Min] Shinwoo Cooperat Ltd, 991 Worasan Ro, Jinju 52839, Gyeongsangnam D, South Korea.
   [Jang, Ji Tae] Aqua Green Technol Co Ltd, Smart Bldg,Jeju Sci Pk, Jeju 63309, South Korea.
   [Jeon, You-Jin] Jeju Natl Univ, Dept Marine Life Sci, Jeju 63243, South Korea.
   [Choi, Chang Hu; Park, Kook Yang; Son, Kuk Hui] Gachon Univ, Gil Med Ctr, Dept Thorac & Cardiovasc Surg, Incheon 21565, South Korea.
C3 Gachon University; Gachon University; Gachon University; Jeju National
   University; Gachon University
RP Byun, K (corresponding author), Gachon Univ, Dept Anat & Cell Biol, Coll Med, Incheon 21936, South Korea.; Byun, K (corresponding author), Gachon Univ, Grad Sch, Coll Med, Funct Cellular Networks Lab,Dept Med, Incheon 21999, South Korea.; Byun, K (corresponding author), Gachon Univ, Lee Gil Ya Canc & Diabet Inst, Incheon 21999, South Korea.; Son, KH (corresponding author), Gachon Univ, Gil Med Ctr, Dept Thorac & Cardiovasc Surg, Incheon 21565, South Korea.
EM mjson@gachon.ac.kr; seyeon8965@gachon.ac.kr; hsl@gachon.ac.kr;
   jdm@shinwoocorp.com; whiteyasi@gmail.com; youjin2014@gmail.com;
   cch624@gilhospital.com; kkyypark@gilhospital.com; dr632@gilhospital.com;
   khbyunl@gachon.ac.kr
RI Lee, Hye/J-2154-2015; Jeon, You-Jin/AAR-5061-2020; Son,
   myeongjoo/GWQ-6808-2022
OI Jeon, You-Jin/0000-0003-3299-7266; Son, Myeongjoo/0000-0002-9104-3991;
   Byun, kyunghee/0000-0001-8678-8932; Oh, Seyeon/0000-0002-3565-7139
FU Ministry of Oceans and Fisheries, Republic of Korea [20170285]
FX This research was part of a project entitled 'Development of functional
   food products with natural materials derived from marine resources' (no.
   20170285), funded by the Ministry of Oceans and Fisheries, Republic of
   Korea.
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NR 90
TC 26
Z9 27
U1 2
U2 5
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD NOV
PY 2019
VL 11
IS 11
AR 2795
DI 10.3390/nu11112795
PG 16
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA JV3OC
UT WOS:000502274600246
PM 31731817
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Nagae, A
   Fujita, M
   Kawarazaki, H
   Matsui, H
   Ando, K
   Fujita, T
AF Nagae, Ai
   Fujita, Megumi
   Kawarazaki, Hiroo
   Matsui, Hiromitsu
   Ando, Katsuyuki
   Fujita, Toshiro
TI Sympathoexcitation by Oxidative Stress in the Brain Mediates Arterial
   Pressure Elevation in Obesity-Induced Hypertension
SO CIRCULATION
LA English
DT Article
DE brain; hypertension; obesity; oxidative stress; sympathetic nervous
   system
ID DIET-INDUCED OBESITY; ROSTRAL VENTROLATERAL MEDULLA; SALT-SENSITIVE
   HYPERTENSION; SYMPATHETIC-NERVOUS-SYSTEM; ANGIOTENSIN-II;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; BLOOD-PRESSURE; NADPH OXIDASE;
   NAD(P)H OXIDASE
AB Background-Obesity is one of the major risk factors for cardiovascular disease and is often associated with increased oxidative stress and sympathoexcitation. We have already suggested that increased oxidative stress in the brain modulates the sympathetic regulation of arterial pressure in salt-sensitive hypertension, which is often associated with obesity. The present study was performed to determine whether oxidative stress could mediate central sympathoexcitation in the initial stage of obesity-induced hypertension.
   Methods and Results-Four-week-old male Sprague-Dawley rats were fed a high-fat (45% kcal as fat) or low-fat (10% kcal as fat) diet for 6 weeks. Fat loading elicited hypertension and sympathoexcitation, along with visceral obesity. In urethane-anesthetized and artificially ventilated rats, arterial pressure and renal sympathetic nerve activity decreased in a dose-dependent fashion when 53 or 105 mu mol/kg tempol, a membrane-permeable superoxide dismutase mimetic, was infused into the lateral cerebral ventricle. Central tempol reduced arterial pressure and renal sympathetic nerve activity to a significantly greater extent in high-fat diet-fed hypertensive rats than in low-fat diet-fed normotensive rats. Intracerebroventricular apocynin or diphenyleneiodonium, a reduced NADPH oxidase inhibitor, also elicited markedly greater reductions in arterial pressure and renal sympathetic nerve activity in the high-fat diet-fed rats. In addition, fat loading increased NADPH oxidase activity and NADPH oxidase subunit p22(phox), p47(phox), and gp91(phox) mRNA expression in the hypothalamus.
   Conclusions-In obesity-induced hypertension, increased oxidative stress in the brain, possibly via activation of NADPH oxidase, may contribute to the progression of hypertension through central sympathoexcitation. (Circulation. 2009; 119: 978-986.)
C1 [Fujita, Toshiro] Univ Tokyo, Fac Med, Dept Nephrol & Endocrinol, Bunkyo Ku, Tokyo 1138655, Japan.
C3 University of Tokyo
RP Fujita, T (corresponding author), Univ Tokyo, Fac Med, Dept Nephrol & Endocrinol, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1138655, Japan.
EM fujita-dis@h.u-tokyo.ac.jp
OI Fujita, Toshiro/0000-0001-9141-7060
FU Daiichi Sankyo Co Ltd
FX This work was supported by grants from the Daiichi Sankyo Co Ltd.
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NR 50
TC 115
Z9 128
U1 0
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0009-7322
EI 1524-4539
J9 CIRCULATION
JI Circulation
PD FEB 24
PY 2009
VL 119
IS 7
BP 978
EP U102
DI 10.1161/CIRCULATIONAHA.108.824730
PG 12
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 410RT
UT WOS:000263596500010
PM 19204299
OA Bronze
DA 2025-06-11
ER

PT J
AU Kettunen, O
   Kyröläinen, H
   Santtila, M
   Vuorimaa, T
   Vasankari, TJ
AF Kettunen, O.
   Kyrolainen, H.
   Santtila, M.
   Vuorimaa, T.
   Vasankari, T. J.
TI Greater levels of cardiorespiratory and muscular fitness are associated
   with low stress and high mental resources in normal but not overweight
   men
SO BMC PUBLIC HEALTH
LA English
DT Article
DE Physical fitness; Leisure-time physical activity; Stress; Mental
   resources; Body weight
ID TIME PHYSICAL-ACTIVITY; QUALITY-OF-LIFE; METABOLIC SYNDROME; CHRONIC
   ILLNESS; BODY-MASS; YOUNG MEN; EXERCISE; OBESITY; HEALTH; SYMPTOMS
AB Background: The aim of the present study was to investigate how cardio respiratory (CRF) and muscular fitness (MF) together with leisure-time physical activity (LTPA) influence stress symptoms and mental resources among normal-weight and overweight men, because it is not known how body weight affects this association.
   Methods: In a cross-sectional study, 824 men (mean +/- SD: age 25 +/- 5 y, weight 81 +/- 13 kg, BMI 25 +/- 4 kg/m(2)) underwent CRF and MF tests and completed LTPA and stress questionnaires. For the analysis, the subjects were divided into BMI groups (normal vs. overweight) and CRF / MF / LTPA (low, moderate, high) tertiles.
   Results: Normal-weight men with low CRF reported 12 % (p = 0.001) more stress symptoms (SS) compared to normal-weight men with moderate CRF, and 13 % (p = 0.004) more SS compared to normal-weight men with high CRF. Normal-weight men with low MF reported 13 % (p = 0.001) higher SS compared to normal-weight men with moderate MF and 16 % (p = 0.002) more SS compared to men with high MF. Among overweight men, there were no significant differences in SS or mental resources (MR) between the low, moderate and high CRF and MF tertiles. Overweight men with high CRF experienced 8 % (p = 0.039) more SS compared to normal-weight participants with high CRF when age, tobacco and alcohol use, MF and LTPA were considered as covariates (p = 0.014).
   Conclusion: Higher CRF and MF are associated with lower stress and higher mental resources in normal-weight men, but in overweight men, these relationships may differ.
C1 [Kettunen, O.] Univ Turku, Dept Hlth & Exercise, Turku, Finland.
   [Kettunen, O.] Univ Turku, Paavo Nurmi Ctr, Turku, Finland.
   [Kettunen, O.] Sports Inst Finland, Dept Hlth & Exercise, Vierumaki, Finland.
   [Kyrolainen, H.] Univ Jyvaskyla, Dept Biol Phys Act, Jyvaskyla, Finland.
   [Kyrolainen, H.; Santtila, M.] Natl Def Univ, Helsinki, Finland.
   [Vuorimaa, T.] Haaga Helia Univ Appl Sci, Vierumaki, Finland.
   [Vasankari, T. J.] UKK Inst Hlth Promot Res, Tampere, Finland.
C3 University of Turku; University of Turku; University of Jyvaskyla;
   Haaga-Helia University of Applied Sciences; UKK Institute
RP Kettunen, O (corresponding author), Univ Turku, Dept Hlth & Exercise, Turku, Finland.; Kettunen, O (corresponding author), Univ Turku, Paavo Nurmi Ctr, Turku, Finland.; Kettunen, O (corresponding author), Sports Inst Finland, Dept Hlth & Exercise, Vierumaki, Finland.
EM oili.kettunen@vierumaki.fi
RI Singh, Ambrish/W-2163-2017
OI Kyrolainen, Heikki/0000-0003-3822-1733
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NR 47
TC 8
Z9 9
U1 0
U2 9
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-2458
J9 BMC PUBLIC HEALTH
JI BMC Public Health
PD AUG 15
PY 2016
VL 16
AR 788
DI 10.1186/s12889-016-3470-6
PG 9
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA DT5UM
UT WOS:000381548500003
PM 27527495
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Moure, R
   Domingo, P
   Villarroya, J
   Gasa, L
   Gallego-Escuredo, JM
   Quesada-López, T
   Morón-Ros, S
   Maroto, AF
   Mateo, GM
   Domingo, JC
   Villarroya, F
   Giralt, M
AF Moure, Ricardo
   Domingo, Pere
   Villarroya, Joan
   Gasa, Laura
   Gallego-Escuredo, Jose M.
   Quesada-Lopez, Tania
   Moron-Ros, Samantha
   Maroto, Alberto F.
   Mateo, Gracia M.
   Domingo, Joan C.
   Villarroya, Francesc
   Giralt, Marta
TI Reciprocal Effects of Antiretroviral Drugs Used To Treat HIV Infection
   on the Fibroblast Growth Factor 21/β-Klotho System
SO ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
LA English
DT Article
DE antiretroviral drug; FGF21; beta-Klotho; ER stress; hepatocyte;
   adipocyte
ID HUMAN ADIPOCYTE DIFFERENTIATION; UNFOLDED PROTEIN RESPONSE;
   ACTIVATED-RECEPTOR-GAMMA; SERUM FGF21 LEVELS; GENE-EXPRESSION; OXIDATIVE
   STRESS; ADIPOSE-TISSUE; HIV-1-INFECTED PATIENTS; METABOLIC SYNDROME;
   CELLS INVOLVEMENT
AB Following antiretroviral therapy, HIV-infected patients show increased circulating levels of the antidiabetic hormone fibroblast growth factor 21 (FGF21). In contrast, the expression of the FGF21-obligatory coreceptor beta-Klotho (KLB) is reduced in target tissues. This situation is comparable to the FGF21 resistance status observed in obesity and type 2 diabetes. Here, we performed the first systematic study of the effects of distinct members of different antiretroviral drug classes on the FGF21/KLB system in human hepatic, adipose, and skeletal muscle cells. Most protease inhibitors and the nonnucleoside reverse transcriptase inhibitor efavirenz induced FGF21 gene expression. Neither nucleoside reverse transcriptase inhibitors nor the viral entry inhibitor maraviroc had any effect. Among the integrase inhibitors, elvitegravir significantly induced FGF21 expression, whereas raltegravir had minor effects only in adipose cells. In human hepatocytes and adipocytes, known target cells of FGF21 action, efavirenz, elvitegravir, and the lopinavir-ritonavir combination exerted inhibitory effects on KLB gene expression. Drug treatments that elicited FGF21 induction/KLB repression were those found to induce endoplasmic reticulum (ER) stress and oxidative stress. Notably, the pharmacological agents thapsigargin and tunicamycin, which induce these stress pathways, mimicked the effects of drug treatments. Moreover, pharmacological inhibitors of either ER or oxidative stress significantly impaired lopinavir-ritonavir-induced regulation of FGF21, but not KLB. In conclusion, the present in vitro screen study identifies the antiretroviral drugs that affect FGF21/KLB expression in human cells. The present results could have important implications for the management of comorbidities resulting from side effects of specific antiretroviral drugs for the treatment of HIV-infected patients.
C1 [Moure, Ricardo; Villarroya, Joan; Gasa, Laura; Quesada-Lopez, Tania; Moron-Ros, Samantha; Maroto, Alberto F.; Domingo, Joan C.; Villarroya, Francesc; Giralt, Marta] Univ Barcelona, Inst Biomed IBUB, Dept Biochem & Mol Biomed, Barcelona, Catalonia, Spain.
   [Moure, Ricardo; Quesada-Lopez, Tania; Moron-Ros, Samantha; Villarroya, Francesc; Giralt, Marta] CIBER Fisiopatol Obesidad & Nutr, Madrid, Spain.
   [Domingo, Pere; Villarroya, Joan; Mateo, Gracia M.] Autonomous Univ Barcelona, Hosp Santa Creu & St Pau, Infect Dis Unit, Barcelona, Catalonia, Spain.
   [Domingo, Pere; Gallego-Escuredo, Jose M.] Inst Recerca Biomed IRB Lleida, Lleida, Catalonia, Spain.
   [Domingo, Pere] Hosp Arnau Vilanova, Dept Infect Dis, Lleida, Catalonia, Spain.
   [Domingo, Pere] Hosp Univ Santa Maria, Dept Infect Dis, Lleida, Catalonia, Spain.
   [Domingo, Pere] Univ Lleida, Lleida, Catalonia, Spain.
C3 University of Barcelona; CIBER - Centro de Investigacion Biomedica en
   Red; CIBEROBN; Autonomous University of Barcelona; Hospital of Santa
   Creu i Sant Pau; Institut de Recerca Biomedica - IRB Lleida; University
   Hospital Arnau de Vilanova; Universitat de Lleida
RP Giralt, M (corresponding author), Univ Barcelona, Inst Biomed IBUB, Dept Biochem & Mol Biomed, Barcelona, Catalonia, Spain.; Giralt, M (corresponding author), CIBER Fisiopatol Obesidad & Nutr, Madrid, Spain.
EM mgiralt@ub.edu
RI Morón-Ros, Samantha/AAB-1959-2021; Villarroya, Francesc/K-4357-2014;
   Domingo, Pere/AAP-7571-2021; Villarroya, Joan/W-4066-2018; Giralt,
   Marta/A-4756-2013; Quesada Lopez, Tania Paloma/L-6690-2018; Domingo
   Pedrol, Joan Carles/A-4856-2019
OI Villarroya, Joan/0000-0002-7859-1109; Villarroya,
   Francesc/0000-0003-1266-9142; Giralt, Marta/0000-0001-7968-4190; Quesada
   Lopez, Tania Paloma/0000-0002-7818-4351; Domingo Pedrol, Joan
   Carles/0000-0002-6356-0836; Moron-Ros, Samantha/0000-0002-6205-2442
FU Fondo de Investigaciones Sanitarias, Instituto de Salud Carlos III
   ([ISCIII]) [PI14/00063, PI14/00700, PI17/00420, PI17/00498]; Ministerio
   de Economia y Competitividad ([MINECO]) [SAF2014-23636, SAF2017-85722];
   European Regional Development Fund (ERDF); Red de Investigacion en SIDA,
   ISCIII, Spain [RD16/0025/0006]; AES, ISCIII, MINECO, Spain; CONACyT
   (National Council for Science and Technology in Mexico)
FX This research was supported by grants from Fondo de Investigaciones
   Sanitarias, Instituto de Salud Carlos III ([ISCIII] PI14/00063,
   PI14/00700, PI17/00420, and PI17/00498) and the Ministerio de Economia y
   Competitividad ([MINECO] SAF2014-23636 and SAF2017-85722), cofinanced by
   the European Regional Development Fund (ERDF) and Red de Investigacion
   en SIDA (RD16/0025/0006), ISCIII, Spain. R.M. was supported by a PFIS
   PhD scholarship from AES, ISCIII, MINECO, Spain. T.Q.-L. was supported
   by a CONACyT (National Council for Science and Technology in Mexico) PhD
   scholarship.
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NR 48
TC 11
Z9 13
U1 0
U2 7
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0066-4804
EI 1098-6596
J9 ANTIMICROB AGENTS CH
JI Antimicrob. Agents Chemother.
PD JUN
PY 2018
VL 62
IS 6
AR e00029-18
DI 10.1128/AAC.00029-18
PG 13
WC Microbiology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Microbiology; Pharmacology & Pharmacy
GA GH2OC
UT WOS:000433240200028
PM 29661866
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Dasilva, G
   Pazos, M
   García-Egido, E
   Gallardo, JM
   Rodríguez, I
   Cela, R
   Medina, I
AF Dasilva, Gabriel
   Pazos, Manuel
   Garcia-Egido, Eduardo
   Manuel Gallardo, Jose
   Rodriguez, Isaac
   Cela, Rafael
   Medina, Isabel
TI Healthy effect of different proportions of marine ω-3 PUFAs EPA and DHA
   supplementation in Wistar rats: Lipidomic biomarkers of oxidative stress
   and inflammation
SO JOURNAL OF NUTRITIONAL BIOCHEMISTRY
LA English
DT Article
DE Lipid mediators; Fish oil; EPA; DHA; Oxidative stress; Inflammation
ID POLYUNSATURATED FATTY-ACIDS; C-REACTIVE PROTEIN; FISH-OIL; PLASMA;
   ASSIGNMENTS; METABOLISM; EXTRACTION; RESOLVINS; MEDIATORS; OBESITY
AB Dietary intervention with omega-3 marine fatty acids may potentially modulate inflammation and oxidative stress markers related with CVD, metabolic syndrome and cancer. The aim of this study was to evaluate whether different proportions of omega-3 EPA and DHA intake provoke a modulation of the production of lipid mediators and then, an influence on different indexes of inflammation and oxidative stress in a controlled dietary animal experiment using Wistar rats. For such scope, a lipidomic SPE-LC-ESI-MS/MS approach previously developed was applied to determine lipid mediators profile in plasma samples. The effect of omega-3 fatty acids associated to different ratios EPA:DHA was compared with the effect exerted by omega-3 ALA supplementation from linseed oil and omega-6 LA from soybean oil. CRP showed a tendency to greater inflammatory status in all omega-3-fed animals. Interestingly, ratios 1:1 and 2:1 EPA:DHA evidenced a noteworthy healthy effect generating a less oxidative environment and modulating LOX and COX activities toward a decrease in the production of proinflammatory ARA eicosanoids and oxidative stress biomarkers from EPA and DHA. In addition, the ability of 1:1 and 2:1 fish oil diets to reduce lipid mediator levels was in concurrence with the protective effect exerted by decreasing inflammatory markers as omega-6/omega-3 ratio in plasma and membranes. It was also highlighted the effect of a higher DHA amount in the diet reducing the healthy benefits described in terms of inflammation and oxidative stress. Results support the antiinflammatory and antioxidative role of fish oils and, particularly, the effect of adequate proportions EPA:DHA. (C) 2015 Elsevier Inc. All rights reserved.
C1 [Dasilva, Gabriel; Pazos, Manuel; Garcia-Egido, Eduardo; Manuel Gallardo, Jose; Medina, Isabel] CSIC, IIM, E-36208 Vigo, Galicia, Spain.
   [Dasilva, Gabriel; Rodriguez, Isaac; Cela, Rafael] Univ Santiago de Compostela, Dept Analyt Chem Nutr & Bromatol, E-15782 Santiago De Compostela, Galicia, Spain.
   [Dasilva, Gabriel; Rodriguez, Isaac; Cela, Rafael] Univ Santiago de Compostela, Res Inst Food Anal IIAA, E-15782 Santiago De Compostela, Galicia, Spain.
C3 Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Instituto
   de Investigaciones Marinas (IIM); Universidade de Santiago de
   Compostela; Universidade de Santiago de Compostela
RP Dasilva, G (corresponding author), Inst Invest Marinas Punta Betin, C Eduardo Cabello 6, Vigo 36208, Spain.
EM gabrieldasilva@iim.csic.es
RI MEDINA, ISABEL/AAL-4012-2021; Cela, Rafael/G-3358-2013; Pazos,
   Manuel/N-5007-2014; Rodriguez Pereiro, Isaac/H-4771-2015
OI Pazos, Manuel/0000-0003-1571-5730; MEDINA, ISABEL/0000-0002-1854-3359;
   Rodriguez Pereiro, Isaac/0000-0002-9693-2042; dasilva,
   gabriel/0000-0002-1650-820X
FU Spanish Ministerio de Economia y Competitividad [AGL2013-49079-C2-1-R];
   Consejo Superior de Investigaciones Cientificas (CSIC); University of
   Santiago de Compostela; postdoctoral "Isidro Parga Pondal" contract;
   "Jae-Doc" contract
FX This work was supported by the Spanish Ministerio de Economia y
   Competitividad (AGL2013-49079-C2-1-R). The Consejo Superior de
   Investigaciones Cientificas (CSIC) and the University of Santiago de
   Compostela are gratefully acknowledged for the doctoral fellowship to
   G.D. Xunta de Galicia and European Social Fund are also thankfully
   recognized by the financial support of the postdoctoral "Isidro Parga
   Pondal" contract to M.P and "Jae-Doc" contract to E.G.-E.
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NR 45
TC 62
Z9 68
U1 1
U2 60
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0955-2863
EI 1873-4847
J9 J NUTR BIOCHEM
JI J. Nutr. Biochem.
PD NOV
PY 2015
VL 26
IS 11
BP 1385
EP 1392
DI 10.1016/j.jnutbio.2015.07.007
PG 8
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA CW4RK
UT WOS:000364979600029
PM 26320676
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Kathirvel, E
   Morgan, K
   French, SW
   Morgan, TR
AF Kathirvel, Elango
   Morgan, Kengathevy
   French, Samuel W.
   Morgan, Timothy R.
TI Overexpression of liver-specific cytochrome P4502E1 impairs hepatic
   insulin signaling in a transgenic mouse model of nonalcoholic fatty
   liver disease
SO EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
LA English
DT Article
DE cytochrome P4502E1; insulin resistance; nonalcoholic fatty liver
   disease; oxidative stress
ID OXIDATIVE STRESS; LIPID-PEROXIDATION; METABOLIC SYNDROME; RESISTANCE;
   OBESITY; 2E1; STEATOHEPATITIS; STEATOSIS; CYP2E1; CELL
AB Objective Cytochrome P4502E1 (CYP2E1) expression in the liver is increased in nonalcoholic fatty liver disease. The aim of this study was to determine whether CYP2E1 overexpression in the liver interferes with insulin signaling pathways in a mouse model of nonalcoholic fatty liver disease.
   Methods Male mice containing the human CYP2E1 transgene under control of the mouse albumin enhancer-promoter (Tg) and control, nontransgenic mice were fed a diet containing 20% calories from fat for 8 months ad libitum.
   Measurements Liver injury was measured by histology and alanine aminotransferase. Malondialdehyde and protein carbonyls were measured as markers of oxidative stress. Total and phosphorylated proteins involved in the insulin signaling cascade were measured by western blotting.
   Results Tg mice had higher fasting insulin, and greater hepatic fat accumulation and histological liver injury. Malondialdehyde and protein carbonyls were increased in Tg mice liver indicating increased oxidative stress. Tyrosine phosphorylation of insulin receptor substrates 1 and 2, and serine phosphorylation of PKB/Akt, were significantly decreased in Tg mice. Serine phosphorylation of glycogen synthase kinase 3 alpha was decreased in Tg mice and liver glycogen content was decreased correspondingly. Serine phosphorylation of the transcription factor Fox01a was decreased, and expression of the enzyme phosphoenolcarboxykinase was increased in Tg mice.
   Conclusion Hepatocyte-specific overexpression of CYP2E1 increased hepatic oxidative stress in the liver, fasting insulin, and histological liver damage. CYP2E1 overexpression reduced hepatic insulin signaling and reduced glycogen storage and increased glucose synthesis. Overall, this study suggests an association of hepatic CYP2E1 with increased oxidative stress, increased systemic insulin resistance, decreased insulin signaling in the liver and increased hepatic fat accumulation. Eur J Gastroenterol Hepatol 21: 973-983 (C) 2009 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
C1 [Kathirvel, Elango; Morgan, Kengathevy; Morgan, Timothy R.] VA Long Beach Healthcare Syst, Res Serv, Long Beach, CA 90822 USA.
   [Kathirvel, Elango; Morgan, Kengathevy; Morgan, Timothy R.] Univ Calif Irvine, Dept Med, Irvine, CA 92717 USA.
   [French, Samuel W.] Harbor UCLA Med Ctr, Dept Pathol, Torrance, CA 90509 USA.
C3 US Department of Veterans Affairs; Veterans Health Administration (VHA);
   VA Long Beach Healthcare System; University of California System;
   University of California Irvine; University of California System;
   University of California Los Angeles; University of California Los
   Angeles Medical Center
RP Morgan, TR (corresponding author), VA Long Beach Healthcare Syst, Res Serv, Post Code 11,5901 E 7th St, Long Beach, CA 90822 USA.
EM timothy.morgan@va.gov
FU Southern California Institute of Research and Education, Long Beach,
   California; University of Southern California Research Center for
   Alcoholic, Liver and Pancreatic Diseases Morphology [NIH/NIAAA
   p50-011999-08]; Vicki and Joshi Krishna Foundation
FX Financial support was provided by the Southern California Institute of
   Research and Education, Long Beach, California and by the University of
   Southern California Research Center for Alcoholic, Liver and Pancreatic
   Diseases Morphology Core grant NIH/NIAAA p50-011999-08. Additional
   financial assistance was provided by the Vicki and Joshi Krishna
   Foundation.
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NR 52
TC 46
Z9 53
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0954-691X
EI 1473-5687
J9 EUR J GASTROEN HEPAT
JI Eur. J. Gastroenterol. Hepatol.
PD SEP
PY 2009
VL 21
IS 9
BP 973
EP 983
DI 10.1097/MEG.0b013e328328f461
PG 11
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 556WD
UT WOS:000274623100003
PM 19307976
DA 2025-06-11
ER

PT J
AU Rankin, JW
   Turpyn, AD
AF Rankin, Janet W.
   Turpyn, Abigail D.
TI Low carbohydrate, high fat diet increases C-reactive protein during
   weight loss
SO JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION
LA English
DT Article; Proceedings Paper
CT Meeting of the Southeast-American-College-of-Sports-Medicine
CY 2005
CL Atlanta, GA
SP SE Amer Coll Sports Med
DE inflammation; oxidative stress; obesity; weight loss; diet composition
ID METABOLIC SYNDROME; PLASMA-CONCENTRATIONS; INSULIN-RESISTANCE; OXIDATIVE
   STRESS; RANDOMIZED-TRIAL; KETOGENIC DIET; INFLAMMATION; OBESITY;
   MARKERS; BIOMARKERS
AB Objective: Chronic inflammation is associated with elevated risk of heart disease and may be linked to oxidative stress in obesity. Our objective was to evaluate the effect of weight loss diet composition (low carbohydrate, high fat, LC or high carbohydrate, low fat, HC) on inflammation and to determine whether this was related to oxidative stress.
   Methods: Twenty nine overweight women, BMI 32.1 +/- 5.4 kg/m(2), were randomly assigned to a self-selected LC or HC diet for 4 wks. Weekly group sessions and diet record collections helped enhance compliance. Body weight, markers of inflammation (serum interleukin-6, IL-6; C-reactive protein, CRP) oxidative stress (urinary 8-epi-prostaglandin F2 alpha, 8-epi) and fasting blood glucose and free fatty acids were measured weekly.
   Results: The diets were similar in caloric intake (1357 kcal/d LC vs. 1361 HC, p = 0.94), but differed in macronutrients (58, 12, 30 and 24, 59, 18 for percent of energy as fat, carbohydrate, and protein for LC and HC, respectively). Although LC lost more weight (3.8 +/- 1.2 kg LC vs. 2.6 +/- 1.7 HC, p = 0.04), CRP increased 25%; this factor was reduced 43% in HC (p = 0.02). For both groups, glucose decreased with weight loss (85.4 vs. 82.1 mg/dl for baseline and wk 4, p < 0.01), while IL-6 increased (1.39 to 1.62 pg/mL, p = 0.04). Urinary 8-epi varied differently over time between groups (p < 0.05) with no consistent pattern.
   Conclusion: Diet composition of the weight loss diet influenced a key marker of inflammation in that LC increased while HC reduced serum CRP but evidence did not support that this was related to oxidative stress.
C1 Virginia Tech, Dept Human Nutr Foods & Exercise, Blacksburg, VA 24061 USA.
C3 Virginia Polytechnic Institute & State University
RP Rankin, JW (corresponding author), Virginia Tech, Dept Human Nutr Foods & Exercise, Blacksburg, VA 24061 USA.
EM jrankin@vt.edu
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NR 37
TC 56
Z9 62
U1 1
U2 24
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 0731-5724
EI 1541-1087
J9 J AM COLL NUTR
JI J. Am. Coll. Nutr.
PD APR
PY 2007
VL 26
IS 2
BP 163
EP 169
DI 10.1080/07315724.2007.10719598
PG 7
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Nutrition & Dietetics
GA 177NE
UT WOS:000247159000010
PM 17536128
DA 2025-06-11
ER

PT J
AU Carallo, C
   Tripolino, C
   De Franceschi, MS
   Irace, C
   Xu, XY
   Gnasso, A
AF Carallo, Claudio
   Tripolino, Cesare
   De Franceschi, Maria Serena
   Irace, Concetta
   Xu, Xiao Yun
   Gnasso, Agostino
TI Carotid endothelial shear stress reduction with aging is associated with
   plaque development in twelve years
SO ATHEROSCLEROSIS
LA English
DT Article
DE Carotid arteries; Haemodynamics; Atherosclerosis
ID CORONARY-ARTERY-DISEASE; METABOLIC SYNDROME; HEART-DISEASE; FLOW;
   ATHEROSCLEROSIS; BLOOD; HYPERTENSION; STIFFNESS; RISK; HEMODYNAMICS
AB Background and aims: Atherosclerosis is associated with clinical, biochemical and haemodynamic risk factors. In a group of subjects studied twelve years apart, we evaluated carotid plaque development in relation to baseline and to changes at follow-up in common carotid haemodynamic profile.
   Methods: Forty-eight participants were recruited to a cardiovascular disease prevention programme. Atherosclerotic plaques were evaluated and scored by echography. Endothelial shear stress, circumferential wall tension, and Peterson's elastic modulus as an index of arterial stiffness, were computed by echo-Doppler, along with blood viscosity data. Binary logistic regression analyses were used to test the association among the development of atherosclerosis, cardiovascular risk factors and haemodynamic variations. Analyses were also performed on participants who presented at the follow-up with carotid haemodynamic variations in the left or right common carotid only.
   Results: Participants (69% male) were aged 64.5 +/- 9.7 years at follow-up. Peak and mean endothelial shear stress was significantly lower at follow-up as previously reported; circumferential wall tension and arterial stiffness were significantly higher. Carotid plaque scores increased after 12 years (0.39 +/- 0.72 vs. 0.67 +/- 0.86, p < 0.01). Of the 96 common carotids analysed, shear stress reduction with aging was an independent predictor of carotid atherosclerosis (B = -0.063; odds ratio = 0.94; p = 0.01). Out of 48 participants, 21 (44%) showed shear stress reduction with aging in only one side of the body and, on this side, the plaque score increased (0.52 +/- 0.98 vs. 0.90 +/- 0.94, p < 0.05), remaining unchanged in the contralateral carotid tree.
   Conclusions: Aging-related shear stress reduction is an independent predictor of atherosclerosis development. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
C1 [Carallo, Claudio; Tripolino, Cesare; De Franceschi, Maria Serena; Irace, Concetta; Gnasso, Agostino] Magna Graecia Univ Catanzaro, Dept Clin & Expt Med, Metab Dis Unit, Viale Europa, I-88100 Catanzaro, Italy.
   [Carallo, Claudio; Xu, Xiao Yun] Imperial Coll London, Dept Chem Engn, South Kensington Campus, London SW7 2AZ, England.
C3 Magna Graecia University of Catanzaro; Imperial College London
RP Carallo, C (corresponding author), Magna Graecia Univ Catanzaro, Mater Domini Hosp, Dept Clin & Expt Med, Metab Dis Unit, Catanzaro, Italy.
EM numemaca@yahoo.it
RI Irace, Concetta/AAC-7796-2022
OI Carallo, Claudio/0000-0002-3958-3245
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NR 33
TC 33
Z9 39
U1 1
U2 12
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0021-9150
EI 1879-1484
J9 ATHEROSCLEROSIS
JI Atherosclerosis
PD AUG
PY 2016
VL 251
BP 63
EP 69
DI 10.1016/j.atherosclerosis.2016.05.048
PG 7
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA DT1SJ
UT WOS:000381262100010
PM 27266823
DA 2025-06-11
ER

PT J
AU Ipar, N
   Aydogdu, SD
   Yildirim, GK
   Inal, M
   Gies, I
   Vandenplas, Y
   Dinleyici, EC
AF Ipar, N.
   Aydogdu, S. Durmus
   Yildirim, G. Kilic
   Inal, M.
   Gies, I.
   Vandenplas, Y.
   Dinleyici, E. C.
TI Effects of synbiotic on anthropometry, lipid profile and oxidative
   stress in obese children
SO BENEFICIAL MICROBES
LA English
DT Article
DE obesity; probiotics; synbiotics; adolescent; prebiotics
ID METABOLIC SYNDROME; WEIGHT-LOSS; PEDIATRIC OBESITY; CONTROLLED-TRIAL;
   GUT MICROBIOTA; PROBIOTICS; SUPPLEMENTATION; OVERWEIGHT; HEALTH; IMPACT
AB Recent studies have suggested some beneficial effects of probiotics and/or prebiotics on obesity in adults; such experience is limited in children and adolescents. This study was an open-label, randomised, controlled study including children with primary obesity. The first group was treated with a standard method with a reduced calorie intake and increased physical activity. The second group received add-on daily synbiotic supplementation during one month. The aim of this study was to evaluate potential effects of a synbiotic on anthropometric measurements, lipid profile and oxidative stress parameters. One month of supplementation of the synbiotic resulted in a significant reduction of weight (P<0.001) and body mass index (P<0.01). Changes (% reduction comparing to baseline) in anthropometric measurements, were significantly higher in the children receiving the additional synbiotic supplement (P<0.05). The percentage of children with weight loss was higher in the synbiotic group, but not statistically significant (71.4 vs 64.2%, P>0.05). At the 30th day of synbiotic intervention, serum total cholesterol, low density lipoprotein cholesterol and total oxidative stress levels significantly declined (P<0.05). Changes in serum lipid levels were significantly higher in the synbiotic group (P<0.05). Changes in serum total oxidative stress levels before and after the intervention period, were significant in synbiotic group (P<0.01). In our study, changes in weight, body mass index, and triceps skinfold thickness were higher in the group receiving the one month synbiotic supplement thin in the standard method group. The supplement tested also had a beneficial effect on lipid profile and total oxidative stress. To the best of our knowledge, this is the first study showing the effects of synbiotics on oxidative stress in obese patients with an additional effect on weight loss regarding to previous studies.
C1 [Ipar, N.; Dinleyici, E. C.] Eskisehir Osmangazi Univ, Dept Pediat, Fac Med, TR-26480 Eskisehir, Turkey.
   [Aydogdu, S. Durmus; Yildirim, G. Kilic] Eskisehir Osmangazi Univ, Dept Pediat, Fac Med, Nutr & Metab Unit, TR-26480 Eskisehir, Turkey.
   [Inal, M.] Eskisehir Osmangazi Univ, Dept Biochem, Fac Med, TR-26480 Eskisehir, Turkey.
   [Gies, I.; Vandenplas, Y.] Vrije Univ Brussel, Dept Pediat, UZ Brussel, B-1090 Brussels, Belgium.
C3 Eskisehir Osmangazi University; Eskisehir Osmangazi University;
   Eskisehir Osmangazi University; Vrije Universiteit Brussel
RP Ipar, N (corresponding author), Eskisehir Osmangazi Univ, Dept Pediat, Fac Med, TR-26480 Eskisehir, Turkey.
EM enercagri@gmail.com
RI Dinleyici, Ener/AAF-8688-2019; İpar, Necla/AAQ-1813-2020; Yildirim,
   Gonca/AAB-1596-2020; Gies, Inge/D-5870-2016
OI Dinleyici, Ener Cagri/0000-0002-0339-0134; Ipar,
   Necla/0000-0002-2614-0832; Gies, Inge/0000-0002-8571-0858
FU Eskisehir Osmangazi University Research Project
FX The study was funded by the Eskisehir Osmangazi University Research
   Project.
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NR 28
TC 58
Z9 61
U1 0
U2 32
PU WAGENINGEN ACADEMIC PUBLISHERS
PI WAGENINGEN
PA PO BOX 220, WAGENINGEN, 6700 AE, NETHERLANDS
SN 1876-2883
EI 1876-2891
J9 BENEF MICROBES
JI Benef. Mirbobes
PY 2015
VL 6
IS 6
BP 775
EP 782
DI 10.3920/BM2015.0011
PG 8
WC Microbiology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Microbiology; Nutrition & Dietetics
GA CZ7VF
UT WOS:000367307500002
PM 26259892
DA 2025-06-11
ER

PT J
AU Mas-Fontao, S
   Civantos, E
   Boukichou-Abdelkader, N
   Soto-Catalan, M
   Romeo-Colas, M
   Marco, A
   Gomez-Guerrero, C
   Moreno, JA
   Tuomilehto, J
   Gabriel, R
   Egido, J
   ePREDICE Investigators
AF Mas-Fontao, Sebastian
   Civantos, Esther
   Boukichou-Abdelkader, Nisa
   Soto-Catalan, Manuel
   Romeo-Colas, Marta
   Marco, Arantxa
   Gomez-Guerrero, Carmen
   Moreno, Juan Antonio
   Tuomilehto, Jaakko
   Gabriel, Rafael
   Egido, Jesus
   Investigators, Epredice
TI Oxidative stress and inflammation on metabolic abnormalities and renal
   involvement in prediabetic subjects across Europe
SO NEFROLOGIA
LA English
DT Article
DE Type 2 diabetes; Prediabetes; Chronic kidney disease; Oxidative stress;
   Biomarkers
ID CHRONIC KIDNEY-DISEASE; GLOMERULAR-FILTRATION-RATE; PROTEIN PRODUCTS;
   ARTERIAL STIFFNESS; RISK; INDIVIDUALS; PREDICTION; BIOMARKERS
AB Background: Studying the mechanisms involved in the transition from prediabetes to diabetes and its associated complications, such as kidney disease, is a growing challenge. This study focuses on identifying valuable biomarkers for the early detection of kidney damage, evaluating molecules associated with oxidative stress and inflammation in prediabetic individuals across Europe. Methods: In plasma samples from individuals with prediabetes included in the ePREDICE study, we determined molecules related to oxidative stress (advance oxidative protein products-AOPP) and inflammatory biomarkers (C-reactive protein - CRP; Interleukin 6 - IL-6), and correlated them with anthropometric and biochemical data, assessing their potential for the early diagnosis of renal involvement. Results: Among the 967 people with prediabetes, 94 presented some sign of renal impairment such as albuminuria, hyperfiltration or hypofiltration. Significant variations were identified between oxidative stress and inflammatory biomarkers (upper and lower quartiles of AOPP, CRP and IL6), and parameters associated with blood pressure, glucose metabolism, lipid components of the metabolic syndrome. There were significant associations between AOPP and CRP, and the presence of albuminuria, but not with renal function. Overall, CRP was a better biomarker than IL-6 for most of the parameters studied. Conclusion: These results highlight the important associations of oxidative stress and inflammation with metabolic abnormalities linked to the prediabetic state and its complications such as fatty liver and renal involvement. Although these results need to be confirmed, our study suggests that AOPP and CRP could be simple biomarkers of interest in predicting the risk of loss of renal function in people with prediabetes. (c) 2024 Published by Elsevier Espana, S.L.U. on behalf of Sociedad Espa nola de Nefrolog & imath;<acute accent>a. This is an open access article under the CC BY-NC-ND license (http://creativecommons.
C1 [Mas-Fontao, Sebastian; Civantos, Esther; Soto-Catalan, Manuel; Romeo-Colas, Marta; Marco, Arantxa; Gomez-Guerrero, Carmen; Egido, Jesus] Univ Autonoma Madrid, IIS Fdn Jimenez Diaz, Renal Vasc & Diabet Res Lab, Madrid, Spain.
   [Mas-Fontao, Sebastian; Soto-Catalan, Manuel; Gomez-Guerrero, Carmen; Egido, Jesus] Inst Salud Carlos III, Madrid, Spain.
   [Mas-Fontao, Sebastian; Civantos, Esther] Univ Alfonso X Sabio UAX, Fac Med & Biomed, Madrid, Spain.
   [Boukichou-Abdelkader, Nisa; Gabriel, Rafael] EVIDEM CONSULTORES, Madrid, Spain.
   [Boukichou-Abdelkader, Nisa; Gabriel, Rafael] Asociac Invest & Prevenc Diabet & Enfermedades Car, Madrid, Spain.
   [Moreno, Juan Antonio] Univ Cordoba, Dept Cell Biol Physiol & Immunol, Cordoba, Spain.
   [Moreno, Juan Antonio] Univ Cordoba, Hosp Reina Sofia, Cordoba, Spain.
   [Tuomilehto, Jaakko] World Community Prevent Diabet Fdn WCPD, Madrid, Spain.
   [Tuomilehto, Jaakko] Finnish Inst Hlth & Welf, Helsinki, Finland.
   [Tuomilehto, Jaakko] Univ Helsinki, Dept Publ Hlth, Helsinki, Finland.
   [Gabriel, Rafael] Inst Salud Carlos III, Escuela Nacl Sanidad, Dept Salud Int, Madrid, Spain.
C3 Autonomous University of Madrid; Fundacion Jimenez Diaz; Instituto de
   Salud Carlos III; Universidad de Cordoba; Hospital Universitario Reina
   Sofia - Cordoba; Universidad de Cordoba; University of Helsinki;
   Instituto de Salud Carlos III; Escuela Nacional de Sanidad (ENS)
RP Mas-Fontao, S; Egido, J (corresponding author), Univ Autonoma Madrid, IIS Fdn Jimenez Diaz, Renal Vasc & Diabet Res Lab, Madrid, Spain.; Mas-Fontao, S; Egido, J (corresponding author), Inst Salud Carlos III, Madrid, Spain.; Mas-Fontao, S (corresponding author), Univ Alfonso X Sabio UAX, Fac Med & Biomed, Madrid, Spain.
EM smas@fjd.es; jegido@quironsalud.es
RI Moreno, Juan/B-3487-2018; Mas, S/T-1489-2018; Soto Catalán,
   Manuel/AGQ-4326-2022; Boukichou Abdelkader, Nisa/JXL-2394-2024
OI Boukichou Abdelkader, Nisa/0000-0002-7427-531X
FU Ministerio de Ciencia, Unnovacion y Universidades: FIS/Fondos FEDER
   [PI20/00375, PI20/00487, PI23/00119, PI23/00669]; Spanish Biomedical
   Research Center in diabetes and metabolic diseases (CIBERDEM); Programa
   Operativo FEDER Junta de Andalucia [1381179-R]; Consejeria de Salud y
   Familias-FEDER, Junta de Andalucia [PIGE-0052-2020]; Spanish Ministry of
   Science and Innovation [RYC-2017-22369]; European Regional Development
   Fund/European Social Fund "A way to make Europe"/"Investing in your
   future"; Society of Nephrology (SEN)
FX This research has been founded by a Society of Nephrol-ogy (SEN) grant.
   The research group of J.E. and S.M.-F. are funded by the Ministerio de
   Ciencia, Unnovacion y Universi-dades: FIS/Fondos FEDER (PI20/00375,
   PI20/00487, PI23/00119, PI23/00669) and the Spanish Biomedical Research
   Center in diabetes and metabolic diseases (CIBERDEM) . Programa
   Operativo FEDER Junta de Andalucia (1381179-R) , Consejeria de Salud y
   Familias-FEDER, Junta de Andalucia (PIGE-0052-2020) . The Spanish
   Ministry of Science and Innovation supported the salary of JAM
   (RYC-2017-22369) (Co-funded by European Regional Development
   Fund/European Social Fund "A way to make Europe"/"Investing in your
   future") . The funders had no role in study design, data collection and
   analysis, decision to publish, or preparation of the manuscript.
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NR 38
TC 0
Z9 0
U1 1
U2 1
PU SOC ESPANOLA NEFROLOGIA DR RAFAEL MATESANZ
PI SANTANDER
PA C/PASAJE DE PENA 2, 3-C, SANTANDER, SPAIN
SN 0211-6995
EI 1989-2284
J9 NEFROLOGIA
JI Nefrologia
PD MAR
PY 2025
VL 45
IS 3
BP 238
EP 248
DI 10.1016/j.nefro.2024.10.003
EA MAR 2025
PG 11
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA Z5R5A
UT WOS:001439475200001
PM 40082053
OA gold
DA 2025-06-11
ER

PT J
AU Kim, SC
   Shah, NR
   Rogers, JR
   Bibbo, CF
   Di Carli, MF
   Solomon, DH
AF Kim, Seoyoung C.
   Shah, Nishant R.
   Rogers, James R.
   Bibbo, Courtney F.
   Di Carli, Marcelo F.
   Solomon, Daniel H.
TI Assessment of coronary vascular function with cardiac PET in relation to
   serum uric acid
SO PLOS ONE
LA English
DT Article
ID POSITRON-EMISSION-TOMOGRAPHY; MYOCARDIAL FLOW RESERVE; RB-82 PET;
   MENDELIAN RANDOMIZATION; ENDOTHELIAL DYSFUNCTION; METABOLIC SYNDROME;
   PROGNOSTIC VALUE; ARTERY-DISEASE; HEART-DISEASE; BLOOD-FLOW
AB Background
   Elevated serum uric acid (SUA) levels have been independently associated with cardiovascular disease. Stress myocardial perfusion positron emission tomography (PET) allows for measurement of absolute myocardial blood flow (MBF) and quantification of global left ventricular coronary flow reserve (CFR). A CFR < 2.0 is considered impaired coronary vascular function, and it is associated with increased cardiovascular risk. We evaluated the relationship between SUA and PET-measured markers of coronary vascular function.
   Methods
   We studied adults undergoing a stress myocardial perfusion PET on clinical grounds (1/2006-3/2014) who also had >= 1 SUA measurement within 180 days from the PET date. Multivariable linear regression estimated the association between SUA and PET-derived MBF and CFR. We also stratified analyses by diabetes status.
   Results
   We included 382 patients with mean (SD) age of 68.4 (12.4) years and mean (SD) SUA level of 7.2 (2.6) mg/dl. 36% were female and 29% had gout. Median [IQR] CFR was reduced at 1.6 [1.2, 2.0] and median [IQR] stress MBF was 1.5 [1.1, 2.1] ml/min/g. In the adjusted analysis, SUA was inversely associated with stress MBF (beta = -0.14, p = 0.01) but not with CFR. Among patients without diabetes (n = 215), SUA had a negative association with CFR (beta = -0.15, p = 0.02) and stress MBF (beta = -0.19, p = 0.01) adjusting for age, sex, extent of myocardial scar and ischemia, serum creatinine and gout. In diabetic patients (n = 167), SUA was not associated with either CFR or MBF.
   Conclusions
   In this cross-sectional study, higher SUA is modestly associated with worse CFR and stress MBF among patients without diabetes.
C1 [Kim, Seoyoung C.; Rogers, James R.; Solomon, Daniel H.] Harvard Med Sch, Div Pharmacoepidemiol & Pharmacoecon, Dept Med, Brigham & Womens Hosp, Boston, MA 02115 USA.
   [Kim, Seoyoung C.; Solomon, Daniel H.] Harvard Med Sch, Div Rheumatol Immunol & Allergy, Dept Med, Brigham & Womens Hosp, Boston, MA 02115 USA.
   [Shah, Nishant R.; Bibbo, Courtney F.; Di Carli, Marcelo F.] Harvard Med Sch, Noninvas Cardiovasc Imaging Program, Heart & Vasc Inst,Dept Radiol,Brigham & Womens Ho, Div Cardiovasc Med,Dept Med,Div Nucl Med & Mol Im, Boston, MA USA.
   [Shah, Nishant R.] Brown Univ, Dept Med, Lifespan Cardiovasc Inst, Div Cardiovasc Med,Alpert Sch Med, Providence, RI 02912 USA.
C3 Harvard University; Harvard University Medical Affiliates; Brigham &
   Women's Hospital; Harvard Medical School; Harvard University; Harvard
   Medical School; Harvard University Medical Affiliates; Brigham & Women's
   Hospital; Harvard University; Harvard Medical School; Brown University;
   Lifespan Health Rhode Island
RP Kim, SC (corresponding author), Harvard Med Sch, Div Pharmacoepidemiol & Pharmacoecon, Dept Med, Brigham & Womens Hosp, Boston, MA 02115 USA.; Kim, SC (corresponding author), Harvard Med Sch, Div Rheumatol Immunol & Allergy, Dept Med, Brigham & Womens Hosp, Boston, MA 02115 USA.
EM sykim@bwh.harvard.edu
RI Solomon, Daniel/HTO-5518-2023; Kim, Seoyoung/L-6561-2019
OI Kim, Seoyoung/0000-0002-2517-3579
FU NIH [R21 AR069271, K24 AR055989, P60 AR047782, U34 AR063911, R01
   HL119718, K24 326 AR055989]
FX SCK is supported by a grant from the NIH R21 AR069271. DHS is supported
   by the NIH grants K24 AR055989, P60 AR047782, U34 AR063911, and R01
   HL119718.SCK is supported by a grant from the NIH R21 AR069271. DHS is
   supported by the NIH grants K24 326 AR055989, P60 AR047782, U34
   AR063911, and R01 HL119718.
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NR 28
TC 3
Z9 3
U1 0
U2 0
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD FEB 13
PY 2018
VL 13
IS 2
AR e0192788
DI 10.1371/journal.pone.0192788
PG 12
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA FW1TV
UT WOS:000425083400056
PM 29438436
OA gold, Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Li, SJ
   Ding, ST
   Mersmann, HJ
   Chu, CH
   Hsu, CD
   Chen, CY
AF Li, Sin-Jin
   Ding, Shih-Torng
   Mersmann, Harry J.
   Chu, Chun-Han
   Hsu, Chia-Da
   Chen, Ching-Yi
TI A nutritional nonalcoholic steatohepatitis minipig model
SO JOURNAL OF NUTRITIONAL BIOCHEMISTRY
LA English
DT Article
DE ER stress; Autophagy; NAFLD; SAA; IL-6; Lee-Sung minipigs
ID ENDOPLASMIC-RETICULUM STRESS; FATTY LIVER-DISEASE; METABOLIC SYNDROME;
   SIGNALING PATHWAYS; AUTOPHAGY; OBESITY; ADIPOCYTE; CELLS
AB Background and Aims: The objective of this study was to elucidate whether a Western diet was associated with nonalcoholic steatohepatitis (NASH), and the relationship between NASH, autophagy and endoplasmic reticulum (ER) stress.
   Methods: Four-month-old Lee-Sung minipigs were randomly assigned to two groups: control diet (C) and Western diet (W), for a 5-month experimental period.
   Results: Feeding a Western diet produced a body composition with more fat, less lean and a greater liver weight. Compared with C pigs, W pigs also exhibited an elevated level of plasma insulin and free fatty acid. The W pigs displayed glucose intolerance, lower circulation antioxidant capacity and greater hepatic oxidative stress. Furthermore, pig fed the W diets had increased collagen accumulation in the liver and elevated systemic inflammation [tumor necrosis factor of and interleukin (IL)-6]. Compared with C pigs, W pigs had higher hepatic ER stress-related protein expression of GRP94, CHOP and caspase-12. The W pigs also had greater hepatic autophagy-related protein expression of p62 and LC3II. In an obesity antibody array analysis, W pigs had higher type 2 diabetes mellitus (insulin-like growth factor 1, osteoprotegerin and resistin), atherosclerosis- (vascular endothelial growth factor, platelet-derived growth factor-AA and plasminogen activator inhibitor-I) and inflammation- [IL-1, macrophage-stimulating protein alpha, X-linked ectodermal dysplasia receptor and serum amyloid A (SAA)] related protein expressions. In addition, W pigs had greater plasma SAA concentration than C pigs and plasma SAA level was highly associated with IL-6.
   Conclusions: We successfully established a NASH pig model, and our findings suggested an association of NASH with ER stress and autophagy. The SAA has potential as a novel plasma biomarker for nonalcoholic fatty liver disease pigs. (C) 2015 Elsevier Inc. All rights reserved.
C1 [Li, Sin-Jin; Ding, Shih-Torng; Mersmann, Harry J.; Chu, Chun-Han; Chen, Ching-Yi] Natl Taiwan Univ, Dept Anim Sci & Technol, 50,Lane 155,Sec 3,Keelung Rd, Taipei 10672, Taiwan.
   [Hsu, Chia-Da] Natl Taiwan Univ, Sch Vet Med, 1,Sec 4,Roosevelt Rd, Taipei 106, Taiwan.
C3 National Taiwan University; National Taiwan University
RP Chen, CY (corresponding author), Natl Taiwan Univ, Dept Anim Sci & Technol, 50,Lane 155,Sec 3,Keelung Rd, Taipei 10672, Taiwan.
EM ronichen@ntu.edu.tw
OI Li, Sin-Jin/0000-0002-0010-8439; Chen, Ching-Yi/0000-0002-5776-084X
FU Ministry of Science and Technology [MOST 103-2313-B-002-035, MOST
   104-2313-B-002-038-MY3]; National Taiwan University
   [NTU-CESRP-104R7615-3]
FX This work was supported by the Research Grant MOST 103-2313-B-002-035
   (from the Ministry of Science and Technology), MOST
   104-2313-B-002-038-MY3 (from the Ministry of Science and Technology) and
   NTU-CESRP-104R7615-3 (from National Taiwan University).
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NR 43
TC 19
Z9 22
U1 0
U2 20
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0955-2863
EI 1873-4847
J9 J NUTR BIOCHEM
JI J. Nutr. Biochem.
PD FEB
PY 2016
VL 28
BP 51
EP 60
DI 10.1016/j.jnutbio.2015.09.029
PG 10
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA DF4YS
UT WOS:000371359100006
PM 26878782
DA 2025-06-11
ER

PT J
AU Okada, K
   Warabi, E
   Sugimoto, H
   Horie, M
   Gotoh, N
   Tokushige, K
   Hashimoto, E
   Utsunomiya, H
   Takahashi, H
   Ishii, T
   Yamamoto, M
   Shoda, J
AF Okada, Kosuke
   Warabi, Eiji
   Sugimoto, Hirokazu
   Horie, Masaki
   Gotoh, Naohiro
   Tokushige, Katsutoshi
   Hashimoto, Etsuko
   Utsunomiya, Hirotoshi
   Takahashi, Hiroshi
   Ishii, Tetsuro
   Yamamoto, Masayuki
   Shoda, Junichi
TI Deletion of Nrf2 leads to rapid progression of steatohepatitis in mice
   fed atherogenic plus high-fat diet
SO JOURNAL OF GASTROENTEROLOGY
LA English
DT Article
DE Nrf2 gene-knockout mouse; Transcription factor; Atherogenic plus
   high-fat diet; Fatty acid; Oxidative stress
ID LIVER-DISEASE; NONALCOHOLIC STEATOHEPATITIS; OXIDATIVE STRESS; HEPATIC
   STEATOSIS; INDUCED OBESITY; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   TRANSGENIC MICE; PROTECTS MICE; ACCUMULATION
AB The transcription factor nuclear factor-E2-related factor-2 (Nrf2) inhibits lipid accumulation and oxidative stress in the liver by interfering with lipogenic pathways and inducing antioxidative stress genes.
   The involvement of Nrf2 in defense against the development of steatohepatitis was studied in an experimental model induced by an atherogenic plus high-fat (Ath + HF) diet. Wild-type (WT) and Nrf2-null mice were fed the diet. Their specimens were analyzed for pathology as well as for the expression levels of genes involved in fatty acid metabolism and those involved via the Nrf2 transcriptional pathway.
   In Nrf2-null mice fed the diet, steatohepatitis developed rapidly, leading to precirrhosis. The Ath + HF diet increased hepatic triglyceride levels and changed fatty acid composition in both mouse groups. However, oleic acid (C18:1 n-9) predominated in the livers of Nrf2-null mice. Correlating well with the pathology, the mRNA levels of the factors involved in fatty acid metabolism (Lxr, Srebp-1a, 1c, Acc-1, Fas, Scd-1, and Fatty acid transporting peptides 1, 3, 4), the inflammatory cytokine genes (Tnf-alpha and IL-1 beta), and the fibrogenesis-related genes (Tgf-beta 1 and alpha-Sma) were significantly increased in the livers of Nrf2-null mice fed the diet, compared with the levels of these factors in matched WT mice. Oxidative stress was significantly increased in the livers of Nrf2-null mice fed the diet. This change was closely associated with the decreased levels of antioxidative stress genes.
   Nrf2 deletion leads to the rapid onset and progression of steatohepatitis induced by an Ath + HF diet, through both up-regulation of co-regulators of fatty acid metabolism and down-regulation of oxidative metabolism regulators in the liver.
C1 [Okada, Kosuke; Horie, Masaki; Shoda, Junichi] Univ Tsukuba, Div Med Sci, Fac Med, Tsukuba, Ibaraki 3058574, Japan.
   [Okada, Kosuke; Sugimoto, Hirokazu] Univ Tsukuba, Dept Gastroenterol, Fac Med, Tsukuba, Ibaraki 3058575, Japan.
   [Warabi, Eiji; Ishii, Tetsuro] Univ Tsukuba, Div Biomed Sci, Fac Med, Tsukuba, Ibaraki 3058575, Japan.
   [Gotoh, Naohiro] Tokyo Univ Marine Sci & Technol, Dept Food Sci & Technol, Tokyo 1088477, Japan.
   [Tokushige, Katsutoshi; Hashimoto, Etsuko] Tokyo Womens Med Univ, Dept Internal Med & Gastroenterol, Shinjuku Ku, Tokyo 1628666, Japan.
   [Utsunomiya, Hirotoshi] Wakayama Med Univ, Dept Strateg Surveillance Funct Food & Comprehens, Wakayama 6418509, Japan.
   [Takahashi, Hiroshi] Univ Tsukuba, Dept Anesthesiol, Fac Med, Tsukuba, Ibaraki 3058575, Japan.
   [Yamamoto, Masayuki] Tohoku Univ, Dept Med Biochem, Grad Sch Med, Sendai, Miyagi 9808675, Japan.
C3 University of Tsukuba; University of Tsukuba; University of Tsukuba;
   Tokyo University of Marine Science & Technology; Tokyo Women's Medical
   University; Wakayama Medical University; University of Tsukuba; Tohoku
   University
RP Shoda, J (corresponding author), Univ Tsukuba, Div Med Sci, Fac Med, 1-1-1 Tennodai, Tsukuba, Ibaraki 3058574, Japan.
EM shodaj@md.tsukuba.ac.jp
RI Yamamoto, Masayuki/A-4873-2010
FU Ministry of Education, Culture, Sports, Science and Technology, Japan
   [21300275, 22303799, 22650162]; Grants-in-Aid for Scientific Research
   [23660033, 22650162, 24659104, 22300260, 24390488, 21300275, 24650436]
   Funding Source: KAKEN
FX This work was supported in part by Grants-in-Aid for Scientific Research
   from the Ministry of Education, Culture, Sports, Science and Technology,
   Japan (21300275, 22303799, 22650162).
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NR 37
TC 76
Z9 81
U1 0
U2 24
PU SPRINGER JAPAN KK
PI TOKYO
PA CHIYODA FIRST BLDG EAST, 3-8-1 NISHI-KANDA, CHIYODA-KU, TOKYO, 101-0065,
   JAPAN
SN 0944-1174
J9 J GASTROENTEROL
JI J. Gastroenterol.
PD MAY
PY 2013
VL 48
IS 5
BP 620
EP 632
DI 10.1007/s00535-012-0659-z
PG 13
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 146DF
UT WOS:000319068700006
PM 22972520
DA 2025-06-11
ER

PT J
AU Del Ben, M
   Fabiani, M
   Loffredo, L
   Polimeni, L
   Carnevale, R
   Baratta, F
   Brunori, M
   Albanese, F
   Augelletti, T
   Violi, F
   Angelico, F
AF Del Ben, Maria
   Fabiani, Mario
   Loffredo, Lorenzo
   Polimeni, Licia
   Carnevale, Roberto
   Baratta, Francesco
   Brunori, Marco
   Albanese, Fabiana
   Augelletti, Teresa
   Violi, Francesco
   Angelico, Francesco
TI Oxidative stress mediated arterial dysfunction in patients with
   obstructive sleep apnoea and the effect of continuous positive airway
   pressure treatment
SO BMC PULMONARY MEDICINE
LA English
DT Article
ID VASCULAR ENDOTHELIAL DYSFUNCTION; NITRIC-OXIDE; LIPID-PEROXIDATION;
   FLOW; VASODILATION; INFLAMMATION; CPAP; MEN
AB Background: Several studies suggest an increase of oxidative stress and a reduction of endothelial function in obstructive sleep apnoea syndrome (OSAS). We assessed the association between OSAS, endothelial dysfunction and oxidative stress. Further aim was to evaluate the effect of nasal continuous positive airway pressure (nCPAP) on oxidative stress and arterial dysfunction.
   Methods: We studied 138 consecutive patients with heavy snoring and possible OSAS. Patients underwent unattended overnight home polysomnography. Ten patients with severe OSAS were revaluated after 6 months of nCPAP therapy. To assess oxidative stress in vivo, we measured urinary 8-iso-PGF2 alpha and serum levels of soluble NOX2-derived peptide (sNOX2-dp). Serum levels of nitrite/nitrate (NOx) were also determined. Flow-mediated brachial artery dilation (FMD) was measured to asses endothelial function.
   Results: Patients with severe OSAS had higher urinary 8-iso-PGF2 alpha (p<0.001) and serum NOX2 and lower NOx. A negative association was observed between FMD and OSA severity. Apnea/hypopnea index was significantly correlated with the indices of central obesity and with urinary 8-isoprostanes (r=0.298, p<0.001). The metabolic syndrome (t=-4.63, p<0.001) and urinary 8-isoprostanes (t=-2.02, p<0.05) were the only independent predictors of FMD. After 6-months nCPAP treatment, a significant decrease of serum NOX2, (p<0.005) and urinary 8-iso-PGF2 alpha (p<0.01) was observed, while serum NOx showed only a minor increase. A statistically significant increase of FMD was observed (from 3.6% to 7.0%).
   Conclusions: The results of our study indicate that patients with OSAS and cardiometabolic comorbidities have increased oxidative stress and arterial dysfunction that are partially reversed by nCPAP treatment.
C1 [Del Ben, Maria; Fabiani, Mario; Loffredo, Lorenzo; Polimeni, Licia; Carnevale, Roberto; Baratta, Francesco; Brunori, Marco; Albanese, Fabiana; Augelletti, Teresa; Violi, Francesco; Angelico, Francesco] Univ Roma La Sapienza, Dept Internal Med & Med Special, Rome, Italy.
   [Angelico, Francesco] Policlin Umberto 1, Div Internal Med C, Dept Publ Hlth & Infect Dis, I-00161 Rome, Italy.
C3 Sapienza University Rome; Sapienza University Rome; University Hospital
   Sapienza Rome
RP Angelico, F (corresponding author), Univ Roma La Sapienza, Dept Internal Med & Med Special, Rome, Italy.
EM francesco.angelico@uniroma1.it
RI Violi, Francesco/K-1509-2016; Roberto, Carnevale/K-1472-2016; Del Ben,
   Maria/AAE-7603-2020; Angelico, Francesco/AAB-6585-2020; Loffredo,
   Lorenzo/K-4873-2016
OI Loffredo, Lorenzo/0000-0002-6542-6235
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NR 50
TC 58
Z9 61
U1 0
U2 22
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1471-2466
J9 BMC PULM MED
JI BMC Pulm. Med.
PD JUL 23
PY 2012
VL 12
AR 36
DI 10.1186/1471-2466-12-36
PG 8
WC Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Respiratory System
GA 067BU
UT WOS:000313268600001
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Cotrim, C
   Almeida, AG
   Carrageta, M
AF Cotrim, Carlos
   Almeida, Ana G.
   Carrageta, Manuel
TI Exercise-induced intra-ventricular gradients as a frequent potential
   cause of myocardial ischemia in cardiac syndrome X patients
SO CARDIOVASCULAR ULTRASOUND
LA English
DT Article
ID CORONARY; ECHOCARDIOGRAPHY; OBSTRUCTION
AB Background: The development of intra-ventricular gradients (IVG) during dobutamine or exercise stress is not infrequent, and can be associated to symptoms during stress. The purpose of this study was to assess the occurrence of IVG during exercise stress echocardiography in cardiac syndrome X patients.
   Methods: We prospectively evaluated 91 patients (pts) mean aged 51 +/- 12 years (age ranged 20 to 75 years old), 44 of whom were women. All pts had angina, positive exercise ECG treadmill testing, normal rest echocardiogram and no coronary artery disease on coronary angiogram (cardiac X syndrome). After complete Doppler echocardiographic evaluation with determination of left ventricular outflow tract index (LVOTi), relative left ventricular wall thickness (RLVWT) and left ventricular end-diastolic volume index (LVDVi), all patients underwent stress echocardiography with two-dimensional and Doppler echographic evaluation during and after treadmill exercise.
   Results: For analysis purpose patients were divided in 2 groups, according to the development of IVG. Doppler evidence of IVG was found in 33 (36%) of the patients (Group A), with mean age 47 +/- 14 years old (age ranged 20 to 72 years) and with a mean end-systolic peak gradient of 86 +/- 34 mmHg (ranging from 30 to 165 mmHg). The IVG development was accompanied by SAM of the mitral valve in 23 pts. Three of these pts experienced symptomatic hypotension. Ten were women (30% pts). 58 pts in group B, 34 of whom were women (59%) (p = 0,01 vs group A), mean aged 53,5 +/- 10,9 years old (age ranged 34 to 75 years) ( p = 0,03 vs group A), did not develop IVG. LVOTi was 10,29 +/- 0,9 mm/m(2) in group A and 11,4 +/- 1 mm/m(2) in group B (p < 0,000); RLVWT was 0,36 +/- 0,068 in group A and 0,33 +/- 0,046 in group B (p < 0,01); LVDVi was 44,8 +/- 10 ml/m(2) in group A and 56 +/- 11,6 ml/m(2) in group B (p = 0,000).
   Conclusion: 1. A significant number of patients with cardiac X syndrome developed IVG during upright exercise in treadmill. These pts (group A) are mainly males and younger than those who did not develop IVG.
   2. The development of IVG and mitral valve SAM on exertion seems to be associated with ST segment downsloping during stress testing in patients without epicardial coronary disease.
   3. The development of IVG and mitral valve SAM seems to be associated with lower LVOTi, lower LVDVi and higher RLVWT.
C1 [Cotrim, Carlos; Carrageta, Manuel] Garcia Orta Hosp, Dept Cardiol, Almada, Portugal.
   [Almeida, Ana G.; Carrageta, Manuel] Hosp Santa Maria, Dept Cardiol, Lisbon, Portugal.
   [Cotrim, Carlos; Carrageta, Manuel] Univ Lisbon, Sch Med, P-1699 Lisbon, Portugal.
C3 Hospital Garcia de Orta; Universidade de Lisboa; Hospital Santa Maria;
   Universidade de Lisboa
RP Cotrim, C (corresponding author), Garcia Orta Hosp, Dept Cardiol, Almada, Portugal.
EM carlosadcotrim@hotmail.com; anagalmeida@hotmail.com;
   mcarrageta@mail.telepac.pt
RI Almeida, Ana/AAU-2245-2020; Cotrim, Carlos/AAI-1691-2021
OI Cotrim, Carlos/0000-0002-4282-3473; Reis,
   AlessanRSS/0000-0001-8486-7469; Almeida, Ana Gomes
   de/0000-0003-0360-4363; Cotrim, Carlos/0000-0002-4802-0831
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NR 25
TC 22
Z9 22
U1 0
U2 1
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1476-7120
J9 CARDIOVASC ULTRASOUN
JI Cardiovasc. Ultrasound
PD JAN 14
PY 2008
VL 6
AR 3
DI 10.1186/1476-7120-6-3
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 301PD
UT WOS:000255907200001
PM 18194574
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Yang, NX
   Gonzalez-Vicente, A
   Garvin, JL
AF Yang, Nianxin
   Gonzalez-Vicente, Agustin
   Garvin, Jeffrey L.
TI Angiotensin II-induced superoxide and decreased glutathione in proximal
   tubules: effect of dietary fructose
SO AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
LA English
DT Article
DE kidney; hypertension; salt; NADPH oxidase
ID SMOOTH-MUSCLE-CELLS; INDUCED OXIDATIVE STRESS; THICK ASCENDING LIMB;
   ACUTE KIDNEY INJURY; NADPH OXIDASE; NITRIC-OXIDE; NAD(P)H OXIDASE;
   TUBULOINTERSTITIAL INJURY; DIFFERENTIAL REGULATION; METABOLIC SYNDROME
AB Angiotensin II exacerbates oxidative stress in part by increasing superoxide (O-2(-)) production by many renal tissues. However, whether it does so in proximal tubules and the source of O-2(-) in this segment are unknown. Dietary fructose enhances the stimulatory effect of angiotensin II on proximal tubule Na+ reabsorption, but whether this is true for oxidative stress is unknown. We hypothesized that angiotensin II causes proximal nephron oxidative stress in part by stimulating NADPH oxidase (NOX)4-dependent O-2(-) production and decreasing the amount of the antioxidant glutathione, and this is exacerbated by dietary fructose. We measured basal and angiotensin II-stimulated O-2(-) production with and without inhibitors, NOX1 and NOX4 expression, and total and reduced glutathione (GSH) in proximal tubules from rats drinking either tap water (control) or 20% fructose. Angiotensin II (10 nM) increased O-2(-) production by 113 +/- 42 relative light units.mg protein(-1).s(-1) in controls and 401 +/- 74 relative light units.mg protein(-1).s(-1) with 20% fructose (n = 11 for each group, P < 0.05 vs. control). Apocynin and the Nox1/4 inhibitor GKT136901 prevented angiotensin II-induced increases in both groups. NOX4 expression was not different between groups. NOX1 expression was undetectable. Angiotensin II decreased GSH by 1.8 +/- 0.8 nmol/mg protein in controls and by 4.2 +/- 0.9 nmol/mg protein with 20% fructose (n = 18 for each group, P < 0.047 vs. control). We conclude that 1) angiotensin II causes oxidative stress in proximal tubules by increasing O-2(-) production by NOX4 and decreasing GSH and 2) dietary fructose enhances the ability of angiotensin II to stimulate O-2(-) and diminish GSH. thereby exacerbating oxidative stress in this segment.
C1 [Yang, Nianxin; Gonzalez-Vicente, Agustin; Garvin, Jeffrey L.] Case Western Reserve Univ, Sch Med, Dept Physiol & Biophys, Cleveland, OH 44106 USA.
C3 University System of Ohio; Case Western Reserve University
RP Garvin, JL (corresponding author), Case Western Reserve Univ, Dept Physiol & Biophys, Robbins E532,10900 Euclid Ave, Cleveland, OH 44106 USA.
EM jeffrey.garvin@case.edu
RI Gonzalez-Vicente, Agustin/K-2773-2018
OI Gonzalez-Vicente, Agustin/0000-0002-3682-0815; Yang,
   Nianxin/0000-0002-6842-7874
FU National Heart, Lung, and Blood Institute [HL-128053]
FX This work was supported in part by National Heart, Lung, and Blood
   Institute Grant HL-128053 (to J. L. Garvin).
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NR 92
TC 8
Z9 10
U1 0
U2 3
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 1931-857X
EI 1522-1466
J9 AM J PHYSIOL-RENAL
JI Am. J. Physiol.-Renal Physiol.
PD JAN
PY 2020
VL 318
IS 1
BP F183
EP F192
DI 10.1152/ajprenal.00462.2019
PG 10
WC Physiology; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology; Urology & Nephrology
GA KC9DP
UT WOS:000507471800017
PM 31760771
OA Green Published
DA 2025-06-11
ER

PT J
AU Melhorn, SJ
   Krause, EG
   Scott, KA
   Mooney, MR
   Johnson, JD
   Woods, SC
   Sakai, RR
AF Melhorn, Susan J.
   Krause, Eric G.
   Scott, Karen A.
   Mooney, Marie R.
   Johnson, Jeffrey D.
   Woods, Stephen C.
   Sakai, Randall R.
TI Meal patterns and hypothalamic NPY expression during chronic social
   stress and recovery
SO AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE
   PHYSIOLOGY
LA English
DT Article
DE adiposity; meal size; body composition; food intake
ID CORTICOTROPIN-RELEASING-FACTOR; PITUITARY-ADRENAL AXIS; VISIBLE BURROW
   SYSTEM; FOOD-INTAKE; BODY-WEIGHT; GENE-EXPRESSION; NEUROPEPTIDE-Y;
   PSYCHOSOCIAL STRESS; METABOLIC SYNDROME; MESSENGER-RNA
AB Melhorn SJ, Krause EG, Scott KA, Mooney MR, Johnson JD, Woods SC, Sakai RR. Meal patterns and hypothalamic NPY expression during chronic social stress and recovery. Am J Physiol Regul Integr Comp Physiol 299: R813-R822, 2010. First published July 7, 2010; doi:10.1152/ajpregu.00820.2009.-In the present study, we examined meal patterns during and after exposure to the visible burrow system (VBS), a rodent model of chronic social stress, to determine how the microstructure of food intake relates to the metabolic consequences of social subordination. Male Long-Evans rats were housed in mixed-sex VBS colonies (4 male, 2 female) for 2 wk, during which time a dominance hierarchy formed [1 dominant male (DOM) and 3 subordinate males (SUB)], and then male rats were individually housed for a 3-wk recovery period. Controls were individually housed with females during the 2-wk VBS period and had no changes in ingestive behavior compared with a habituation period. During the hierarchy-formation phase of VBS housing, DOM and SUB had a reduced meal frequency, whereas SUB also had a reduced meal size. However, during the hierarchy-maintenance phase of VBS housing, DOM meal patterns did not differ from controls, whereas SUB continued to display a reduced food intake via less frequent meals. During recovery, DOM had comparable meal patterns to controls, whereas SUB had an increased meal size. Hypothalamic neuropeptide Y (NPY) mRNA levels were not different between these groups during the experimental period. Together, the results suggest that exposure to chronic social stress alters ingestive behavior both acutely and in the long term, which may influence the metabolic changes that accompany bouts of stress and recovery; however, these differences in meal patterns do not appear to be mediated by hypothalamic NPY.
C1 [Melhorn, Susan J.; Krause, Eric G.; Scott, Karen A.; Woods, Stephen C.; Sakai, Randall R.] Univ Cincinnati, Coll Med, Dept Psychiat, Cincinnati, OH USA.
   [Melhorn, Susan J.; Scott, Karen A.] Univ Cincinnati, Coll Med, Program Neurosci, Cincinnati, OH USA.
   [Mooney, Marie R.; Johnson, Jeffrey D.] Univ Cincinnati, Coll Med, Dept Biomed Engn, Cincinnati, OH USA.
C3 University System of Ohio; University of Cincinnati; University System
   of Ohio; University of Cincinnati; University System of Ohio; University
   of Cincinnati
RP Melhorn, SJ (corresponding author), VA Puget Sound Hlth Care Syst, 1660 S Columbian Way,151 Metab, Seattle, WA 98108 USA.
EM smelhorn@u.washington.edu
RI Mooney, Marie/R-5068-2019
OI Krause, Eric/0000-0002-2718-3113; Mooney, Marie/0000-0003-3254-5139;
   Scott, Karen/0000-0002-4133-423X
FU National Institute of Diabetes, Digestive and Kidney Diseases [RO1
   DK066596-06]
FX These studies were supported by the National Institute of Diabetes,
   Digestive and Kidney Diseases Grant RO1 DK066596-06 (to R. R. Sakai).
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NR 57
TC 39
Z9 44
U1 0
U2 2
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0363-6119
EI 1522-1490
J9 AM J PHYSIOL-REG I
JI Am. J. Physiol.-Regul. Integr. Comp. Physiol.
PD SEP
PY 2010
VL 299
IS 3
BP R813
EP R822
DI 10.1152/ajpregu.00820.2009
PG 10
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA 646KA
UT WOS:000281537500011
PM 20610828
OA Green Published
DA 2025-06-11
ER

PT J
AU Huybrechts, I
   De Vriendt, T
   Breidenassel, C
   Rogiers, J
   Vanaelst, B
   Cuenca-García, M
   Moreno, LA
   González-Gross, M
   Roccaldo, R
   Kafatos, A
   Clays, E
   Bueno, G
   Beghin, L
   Sjöstrom, M
   Manios, Y
   Molnár, D
   Pisa, PT
   De Henauw, S
AF Huybrechts, I.
   De Vriendt, T.
   Breidenassel, C.
   Rogiers, J.
   Vanaelst, B.
   Cuenca-Garcia, M.
   Moreno, L. A.
   Gonzalez-Gross, M.
   Roccaldo, R.
   Kafatos, A.
   Clays, E.
   Bueno, G.
   Beghin, L.
   Sjostrom, M.
   Manios, Y.
   Molnar, D.
   Pisa, P. T.
   De Henauw, S.
CA HELENA Study Grp
TI Mechanisms of stress, energy homeostasis and insulin resistance in
   European adolescents - the HELENA study
SO NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
LA English
DT Article
DE Stress; Cortisol; Energy homeostasis; Leptin; Insulin; Glucose; HOMA-IR;
   Adolescents
ID METABOLIC SYNDROME; PUBERTAL CHANGES; OBESE CHILDREN; CORTISOL; LEPTIN;
   DEXAMETHASONE; HUMANS; GLUCOCORTICOIDS; ADIPOSITY; HORMONES
AB Background and aims: Stress is hypothesized to facilitate the development of obesity, whose the foundations are already set during childhood and adolescence. We investigated the relationship between the stress-system, selected mechanisms of energy homeostasis and insulin resistance (IR) in a sample of European adolescents.
   Methods and results: Within HELENA-CSS, 723 adolescents (12.5-17.5 years) from 10 European cities provided all the necessary data for this study. Fasting blood samples were collected for cortisol, leptin, insulin and glucose analysis. HOMA-IR was calculated from insulin and glucose concentrations. Adolescents' body fat (BF) %, age and duration of exclusive breastfeeding were assessed. For boys and girls separately, the relationship of cortisol with leptin, insulin, glucose and HOMA-IR was examined by computing Pearson correlation coefficients and Hierarchical Linear Models (HLMs), with 'city' as cluster unit, adjusting for age, BF% and duration of exclusive breastfeeding. In boys, Pearson correlation coefficients illustrated positive correlations of cortisol with insulin (r = 0.144; p = 0.013), glucose (r = 0.315; p < 0.001) and HOMA-IR (r = 0.180; p = 0.002), whilst in girls, this positive relationship was observed for leptin (r = 0.147; p = 0.002), insulin (r = 0.095; p = 0.050) and HOMA-IR (r = 0.099; p = 0.041), but not for glucose (r = 0.054; p = 0.265). Observed associations were independent of adolescents' age, BF% and duration of exclusive breastfeeding after computing HLMs.
   Conclusion: This study suggests that the stress-system is positively related to mechanisms of energy homeostasis and IR in European adolescents, and reveals a potential small gender difference in this relationship. The hypothesis that stress might facilitate the development of obesity during adolescence is supported. (C) 2014 Elsevier B. V. All rights reserved.
C1 [Huybrechts, I.; De Vriendt, T.; Rogiers, J.; Vanaelst, B.; Clays, E.; De Henauw, S.] Univ Ghent, Dept Publ Hlth, B-9000 Ghent, Belgium.
   [De Vriendt, T.; Vanaelst, B.] Res Fdn Flanders, Brussels, Belgium.
   [Breidenassel, C.; Gonzalez-Gross, M.] Univ Politecn Madrid, Dept Hlth & Human Performance, ImFINE Res Grp, E-28040 Madrid, Spain.
   [Breidenassel, C.; Gonzalez-Gross, M.] Univ Bonn, Dept Human Nutr, Bonn, Germany.
   [Cuenca-Garcia, M.] Univ Granada, Dept Med Physiol, Sch Med, Granada, Spain.
   [Moreno, L. A.; Bueno, G.] Univ Zaragoza, Sch Hlth Sci EUCS, Growth Exercise Nutr & Dev GENUD Res Grp, Zaragoza, Spain.
   [Roccaldo, R.] Ist Nazl Ric Alimenti & Nutr INRAN, Rome, Italy.
   [Kafatos, A.] Univ Crete, Dept Social Med, Sch Med, Prevent Med & Nutr Clin, Iraklion, Greece.
   [Beghin, L.] Univ Lille 2, Fac Med, INSERM, U955,IFR114, Lille, France.
   [Beghin, L.] CHRU Lille, CH&U, Inserm Lille, CIC 9301, F-59037 Lille, France.
   [Sjostrom, M.] Karolinska Inst, Unit Prevent Nutr, Dept Biosci & Nutr, Huddinge, Sweden.
   [Manios, Y.] Harokopio Univ, Dept Nutr & Dietet, Athens, Greece.
   [Molnar, D.] Univ Pecs, Fac Med, Dept Pediat, Pecs, Hungary.
   [De Henauw, S.] Univ Coll Ghent Vesalius, Ghent, Belgium.
   [Huybrechts, I.; Pisa, P. T.] Int Agcy Res Canc, Dietary Exposure Assessment Grp, F-69372 Lyon, France.
   [Pisa, P. T.] Univ Witwatersrand, Dept Paediat, Fac Hlth Sci, MRC Wits Dev Pathways Hlth Res Unit, Johannesburg, South Africa.
C3 Ghent University; Universidad Politecnica de Madrid; University of Bonn;
   University of Granada; University of Zaragoza; University of Crete;
   Universite Paris-Est-Creteil-Val-de-Marne (UPEC); Institut National de
   la Sante et de la Recherche Medicale (Inserm); Universite de Lille;
   Universite de Lille; Institut National de la Sante et de la Recherche
   Medicale (Inserm); CHU Lille; Karolinska Institutet; Harokopio
   University Athens; University of Pecs; HOGENT University College of
   Applied Sciences & Arts; World Health Organization; International Agency
   for Research on Cancer (IARC); University of Witwatersrand
RP Huybrechts, I (corresponding author), Univ Ghent, Dept Publ Hlth, De Pintelaan 185, B-9000 Ghent, Belgium.
EM inge.huybrechts@ugent.be
RI Molnár, Dénes/AAB-6820-2022; Huybrechts, Inge/ITT-7052-2023; Manios,
   Yannis/AAM-8953-2021; BUENO, Maria/AAG-9985-2021; Gonzalez-Gross,
   Marcela/W-8000-2018; Moreno, Luis/S-1780-2019; Cuenca-Garcia,
   Magdalena/H-2183-2015; Vardavas, Constantine/O-4961-2016; gottrand,
   frederic/G-7370-2015; BEGHIN, Laurent/D-4294-2011; Castillo Garzon,
   Manuel Joaquin/E-2242-2019; Azzini, Elena/AAI-9125-2021
OI Cuenca-Garcia, Magdalena/0000-0002-8510-9253; Kwak,
   Lydia/0000-0003-3117-6765; Vardavas, Constantine/0000-0003-0171-9570;
   Gutierrez Sainz, Angel/0000-0003-2788-2739; Clays,
   Els/0000-0002-1092-945X; gottrand, frederic/0000-0002-5290-0436; Moreno
   Aznar, Luis A./0000-0003-0454-653X; BEGHIN, Laurent/0000-0001-5369-3910;
   Castillo Garzon, Manuel Joaquin/0000-0002-1196-9488; Roccaldo,
   Romana/0000-0003-2976-3864; Gonzalez-Gross, Marcela/0000-0001-7757-3235;
   Manios, Yannis/0000-0001-6486-114X; Azzini, Elena/0000-0002-1971-1668
FU European Community [FOOD-CT-2005-007034]; Spanish Ministry of Education
   [AGL2007-29784-E/ALI]; Research Foundation - Flanders (FWO)
   [1174609N01]; Spanish Ministry of Health: Maternal, Child Health and
   Development Network [RD08/0072]
FX The HELENA Study has taken place with the financial support of the
   European Community Sixth RTD Framework Programme (Contract
   FOOD-CT-2005-007034). The content of this article reflects only the
   authors' views and the European Community is not liable for any use that
   may be made of the information contained therein. Additional support
   from the Spanish Ministry of Education (AGL2007-29784-E/ALI). This study
   was also financially supported by the Research Foundation - Flanders
   (FWO, grant no 1174609N01 to T. D. V) and by the Spanish Ministry of
   Health: Maternal, Child Health and Development Network (grant no
   RD08/0072 to L. A. M). The HELENA Study Group would like to acknowledge
   the participating adolescents and their parents for their voluntary
   contribution to the HELENA study. Many thanks to Anke Carstensen, Petra
   Pickert, Rosa Maria Torres and Ulrike Albers for their contribution to
   the laboratory work.
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NR 30
TC 15
Z9 17
U1 0
U2 40
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0939-4753
EI 1590-3729
J9 NUTR METAB CARDIOVAS
JI Nutr. Metab. Carbiovasc. Dis.
PD OCT
PY 2014
VL 24
IS 10
BP 1082
EP 1089
DI 10.1016/j.numecd.2014.04.014
PG 8
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism; Nutrition
   & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism;
   Nutrition & Dietetics
GA AO4NF
UT WOS:000341315900007
PM 24907850
DA 2025-06-11
ER

PT J
AU Eriksson, MD
   Eriksson, JG
   Korhonen, P
   Salonen, MK
   Mikkola, TM
   Kajantie, E
   Wasenius, NS
   von Bonsdorff, M
   Kautiainen, H
   Laine, MK
AF Eriksson, Mia D.
   Eriksson, Johan G.
   Korhonen, Paivi
   Salonen, Minna K.
   Mikkola, Tuija M.
   Kajantie, Eero
   Wasenius, Niko S.
   von Bonsdorff, Mikaela
   Kautiainen, Hannu
   Laine, Merja K.
TI Non-melancholic depressive symptoms are associated with above average
   fat mass index in the Helsinki birth cohort study
SO SCIENTIFIC REPORTS
LA English
DT Article
ID METABOLIC SYNDROME; PHYSICAL-ACTIVITY; OBESITY; PREVALENCE; OVERWEIGHT;
   DISEASE; HEALTH; BMI; INVENTORY; INSULIN
AB There is an existing link between two of the most common diseases, obesity and depression. These are both of great public health concern, but little is known about the relationships between the subtypes of these conditions. We hypothesized that non-melancholic depressive symptoms have a stronger relationship with both body composition (lean mass and fat mass) and dysfunctional glucose metabolism than melancholic depression. For this cross-sectional study 1510 participants from the Helsinki Birth Cohort Study had their body composition evaluated as lean mass and fat mass (Lean Mass Index [LMI, kg/m(2)] + Fat Mass Index [FMI kg/m(2)] = Body Mass Index). Participants were evaluated for depressive symptoms utilizing the Beck depression inventory, and had laboratory assessments including an oral glucose tolerance test. Higher than average FMI was associated with a higher percentage (mean [%], 95% CI) of participants scoring in the depressive range of the Beck depression inventory (20.2, 17.2-23.2) compared to those with low FMI (16.3, 13.8-18.9; p = 0.048) when adjusted for age, sex, education, and fasting plasma glucose concentration. Higher FMI was associated with a higher likelihood of having depressive symptoms (OR per 1-SD FMI = 1.37, 95% CI 1.13-1.65), whereas higher LMI was associated with a lower likelihood of having depressive symptoms (OR per 1-SD LMI = 0.76, 95% CI 0.64-0.91). Participants with an above average FMI more frequently (mean [%], 95% CI) had non-melancholic depressive symptoms (14.7, 11.8-17.7) as compared to those with low FMI (9.7, 7.6-11.9; p = 0.008) regardless of LMI levels. There was no difference between the body composition groups in the likelihood of having melancholic depressive symptoms. The non-melancholic group had higher (mean [kg/m(2)], SD) FMI (9.6, 4.1) than either of the other groups (BDI < 10: 7.7, 3.1; melancholic: 7.9, 3.6; p < 0.001), and a higher (mean [mmol/l], SD) 2-h glucose concentration (7.21, 1.65) than the non-depressed group (6.71, 1.70; p = 0.005). As hypothesized, non-melancholic depressive symptoms are most closely related to high fat mass index and dysfunctional glucose metabolism.
C1 [Eriksson, Mia D.] Helsinki Univ Hosp HUS, Primary Hlth Care Unit, Helsinki, Finland.
   [Eriksson, Mia D.; Eriksson, Johan G.; Salonen, Minna K.; Mikkola, Tuija M.; Wasenius, Niko S.; von Bonsdorff, Mikaela; Kautiainen, Hannu; Laine, Merja K.] Folkhalsan Res Ctr, Helsinki, Finland.
   [Eriksson, Johan G.; Wasenius, Niko S.; Laine, Merja K.] Univ Helsinki, Dept Gen Practice & Primary Hlth Care, Helsinki, Finland.
   [Eriksson, Johan G.; Wasenius, Niko S.; Laine, Merja K.] Helsinki Univ Hosp, Helsinki, Finland.
   [Eriksson, Johan G.] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Obstet & Gynecol, Singapore, Singapore.
   [Eriksson, Johan G.] Natl Univ Singapore, Yong Loo Lin Sch Med, Human Potential Translat Res Programme, Singapore, Singapore.
   [Eriksson, Johan G.] ASTAR, Singapore Inst Clin Sci SICS, Singapore, Singapore.
   [Korhonen, Paivi] Turku Univ Hosp, Dept Gen Practice, Turku, Finland.
   [Korhonen, Paivi] Univ Turku, Turku, Finland.
   [Salonen, Minna K.; Kajantie, Eero] Finnish Inst Hlth & Welf, Dept Publ Hlth Solut, Publ Hlth Promot Unit, Helsinki, Finland.
   [Mikkola, Tuija M.] Univ Helsinki, Fac Med, Clinicum, Helsinki, Finland.
   [Kajantie, Eero] Oulu Univ Hosp, PEDEGO Res Unit, MRC Oulu, Oulu, Finland.
   [Kajantie, Eero] Univ Oulu, Oulu, Finland.
   [Kajantie, Eero] Norwegian Univ Sci & Technol, Dept Clin & Mol Med, Trondheim, Norway.
   [von Bonsdorff, Mikaela] Univ Jyvaskyla, Gerontol Res Ctr, Jyvaskyla, Finland.
   [von Bonsdorff, Mikaela] Univ Jyvaskyla, Fac Sport & Hlth Sci, Jyvaskyla, Finland.
   [Kautiainen, Hannu] Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland.
C3 Folkhalsan Research Center; University of Helsinki; University of
   Helsinki; Helsinki University Central Hospital; National University of
   Singapore; National University of Singapore; Agency for Science
   Technology & Research (A*STAR); A*STAR - Singapore Institute for
   Clinical Sciences (SICS); University of Turku; University of Turku;
   University of Helsinki; University of Oulu; University of Oulu;
   Norwegian University of Science & Technology (NTNU); University of
   Jyvaskyla; University of Jyvaskyla; University of Eastern Finland
RP Eriksson, MD (corresponding author), Helsinki Univ Hosp HUS, Primary Hlth Care Unit, Helsinki, Finland.; Eriksson, MD (corresponding author), Folkhalsan Res Ctr, Helsinki, Finland.
EM mia.eriksson@helsinki.fi
RI von Bonsdorff, Mikaela/A-5218-2015; Gibbs, J. Raphael/A-3984-2010;
   Wasenius, Niko/AAE-8927-2020; /H-8100-2016; Mikkola, Tuija/L-2835-2014
OI /0000-0002-1848-1514; Eriksson, Johan/0000-0002-2516-2060; Eriksson,
   Mia/0000-0001-8968-8304; Wasenius, Niko/0000-0002-9007-6660; Mikkola,
   Tuija/0000-0003-0885-2788
FU Finska Lakaresallskapet; Academy of Finland [126775, 127437, 129255,
   129306, 129907, 130326, 134791, 209072, 210595, 213225, 263924, 275074,
   315690]; EU [733206, 278603, 633595]; European Commission [733280];
   Foundation for Cardiovascular Research; Foundation for Diabetes
   Research; Foundation for Pediatric Research; Novo Nordisk Foundation;
   Signe and Ane Gyllenberg Foundation; Finnish Special Governmental
   Subsidy for Health Sciences; Samfundet Folkhalsan; Liv och Halsa;
   Academy of Finland (AKA) [213225, 275074, 210595, 209072] Funding
   Source: Academy of Finland (AKA)
FX The HBCS has been supported by grants from Finska Lakaresallskapet, the
   Finnish Special Governmental Subsidy for Health Sciences, Academy of
   Finland (126775, 127437, 129255, 129306, 129907, 130326, 134791, 209072,
   210595, 213225, 263924, 275074 and 315690), Samfundet Folkhalsan, Liv
   och Halsa, EU FP7 [Developmental Origins of Healthy Aging (DORIAN)]
   project number 278603, and EU H2020-PHC-2014-DynaHealth grant 633595 and
   EU Horizon 2020 Award 733206 LIFECYCLE (all for the Helsinki Birth
   Cohort Study), European Commission, Horizon2020 award 733280 RECAP,
   Foundation for Cardiovascular Research, Foundation for Diabetes
   Research, Foundation for Pediatric Research, Novo Nordisk Foundation,
   Signe and Ane Gyllenberg Foundation.
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NR 54
TC 1
Z9 1
U1 0
U2 7
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD APR 28
PY 2022
VL 12
IS 1
AR 6987
DI 10.1038/s41598-022-10592-3
PG 11
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 0Z3JY
UT WOS:000790978000059
PM 35484274
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Yoon, SY
   Suh, JH
   Jung, JH
   Lee, SC
   Han, K
   Kim, YW
AF Yoon, Seo Yeon
   Suh, Jee Hyun
   Jung, Jin Hyung
   Lee, Sang Chul
   Han, Kyungdo
   Kim, Yong Wook
TI Suicide Risk and Associated Factors in Parkinson Disease: A Nationwide
   Cohort Study
SO EUROPEAN JOURNAL OF NEUROLOGY
LA English
DT Article
DE alcohol; cohort study; depression; income; Parkinson disease; risk
   factors; suicide
ID METABOLIC SYNDROME; DEPRESSION; DEATH; PREVALENCE; DISORDERS; MORTALITY;
   ALCOHOL; SMOKING
AB BackgroundAlthough increased mortality in patients with Parkinson disease (PD) is well documented, studies on suicide-related mortality have yielded conflicting results. Moreover, the impact of comorbidities, socioeconomic factors and health behaviours as potential risk factors for suicide remains underinvestigated. This study aimed to investigate suicide mortality risk in patients with PD and comprehensively elucidate the association between comorbidities, socioeconomic factors, health behaviours and suicide in PD.MethodsThis nationwide population-based cohort study used Korean National Health Insurance Service data from 2009, with a longitudinal follow-up until 31 December 2021. This study included 2,732,294 (PD, n = 4132; without PD, n = 2,728,162) individuals. PD was defined by ICD-10 code (G20) and registration code (V124). Comorbidities were identified using medical history, ICD-10 codes, laboratory data and prescribed medications. Health behaviours were obtained from a self-reported National Health Screening Program questionnaire. The primary outcome was suicide mortality, determined by ICD-10 codes for intentional self-harm (X60-X84).MethodsThis nationwide population-based cohort study used Korean National Health Insurance Service data from 2009, with a longitudinal follow-up until 31 December 2021. This study included 2,732,294 (PD, n = 4132; without PD, n = 2,728,162) individuals. PD was defined by ICD-10 code (G20) and registration code (V124). Comorbidities were identified using medical history, ICD-10 codes, laboratory data and prescribed medications. Health behaviours were obtained from a self-reported National Health Screening Program questionnaire. The primary outcome was suicide mortality, determined by ICD-10 codes for intentional self-harm (X60-X84).ResultsSuicide mortality in patients with PD increased by 2.71-fold. Males with PD had more than a sevenfold higher risk (HR = 7.34, 95% CI, 5.25-10.26). Low-income patients with PD had an approximately fivefold higher risk compared to high-income non-PD individuals (HR = 5.10, 95% CI, 3.07-8.46). Patients with PD concomitant with depression (HR = 5.00, 95% CI, 3.06-8.16) and alcohol consumption (HR = 3.54, 95% CI, 2.14-5.89) also showed increased suicide risk.ConclusionThis study suggests that patients with PD have a higher risk of suicide, particularly males, those with lower income, depression or alcohol consumption.
C1 [Yoon, Seo Yeon; Lee, Sang Chul; Kim, Yong Wook] Yonsei Univ, Coll Med, Dept & Res Inst Rehabil Med, Seoul, South Korea.
   [Yoon, Seo Yeon] Yonsei Univ, Inst Innovat Digital Healthcare, Seoul, South Korea.
   [Suh, Jee Hyun] Seoul Natl Univ, Coll Med, Dept Rehabil Med, Bundang Hosp, Seongnam, Gyeonggi, South Korea.
   [Jung, Jin Hyung] Sungkyunkwan Univ, Sch Med, Samsung Biomed Res Inst, Suwon, South Korea.
   [Han, Kyungdo] Soongsil Univ, Dept Stat & Actuarial Sci, Seoul, South Korea.
C3 Yonsei University; Yonsei University Health System; Yonsei University;
   Seoul National University (SNU); Sungkyunkwan University (SKKU);
   Soongsil University
RP Kim, YW (corresponding author), Yonsei Univ, Coll Med, Dept & Res Inst Rehabil Med, Seoul, South Korea.; Han, K (corresponding author), Soongsil Univ, Dept Stat & Actuarial Sci, Seoul, South Korea.
EM hkd917@naver.com; ywkim1@yuhs.ac
RI Jung, Jinhyung/AAW-5617-2021; Yoon, Seo/AAH-5176-2021
OI KIM, YONGWOOK/0000-0002-5234-2454
FU National Research Foundation of Korea [RS-2024-00337352]
FX This work was supported by the National Research Foundation of Korea
   (RS-2024-00337352).
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NR 47
TC 0
Z9 0
U1 2
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1351-5101
EI 1468-1331
J9 EUR J NEUROL
JI Eur. J. Neurol.
PD MAR
PY 2025
VL 32
IS 3
AR e70111
DI 10.1111/ene.70111
PG 10
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 0HN5C
UT WOS:001447517400001
PM 40105225
OA hybrid
DA 2025-06-11
ER

PT J
AU Bourdier, G
   Flore, P
   Sanchez, H
   Pepin, JL
   Belaidi, E
   Arnaud, C
AF Bourdier, Guillaume
   Flore, Patrice
   Sanchez, Herve
   Pepin, Jean-Louis
   Belaidi, Elise
   Arnaud, Claire
TI High-intensity training reduces intermittent hypoxia-induced ER stress
   and myocardial infarct size
SO AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
LA English
DT Article
DE obstructive sleep apnea; intermittent hypoxia; ischemia-reperfusion;
   high-intensity aerobic training; endoplasmic reticulum stress
ID ENDOPLASMIC-RETICULUM STRESS; UNFOLDED PROTEIN RESPONSE; CONTINUOUS
   MODERATE EXERCISE; POSITIVE AIRWAY PRESSURE; OBSTRUCTIVE SLEEP-APNEA;
   SKELETAL-MUSCLE; ISCHEMIA-REPERFUSION; CARDIOVASCULAR CONSEQUENCES;
   METABOLIC SYNDROME; CARDIAC MYOCYTES
AB Chronic intermittent hypoxia (IH) is described as the major detrimental factor leading to cardiovascular morbimortality in obstructive sleep apnea (OSA) patients. OSA patients exhibit increased infarct size after a myocardial event, and previous animal studies have shown that chronic IH could be the main mechanism. Endoplasmic reticulum (ER) stress plays a major role in the pathophysiology of cardiovascular disease. High-intensity training (HIT) exerts beneficial effects on the cardiovascular system. Thus, we hypothesized that HIT could prevent IH-induced ER stress and the increase in infarct size. Male Wistar rats were exposed to 21 days of IH (21-5% fraction of inspired O-2, 60-s cycle, 8 h/day) or normoxia. After 1 wk of IH alone, rats were submitted daily to both IH and HIT (2 x 24 min, 15-30m/min). Rat hearts were either rapidly frozen to evaluate ER stress by Western blot analysis or submitted to an ischemia-reperfusion protocol ex vivo (30 min of global ischemia/120 min of reperfusion). IH induced cardiac proapoptotic ER stress, characterized by increased expression of glucose-regulated protein kinase 78, phosphorylated protein kinase-like ER kinase, activating transcription factor 4, and C/EBP homologous protein. IH-induced myocardial apoptosis was confirmed by increased expression of cleaved caspase-3. These IH-associated proapoptotic alterations were associated with a significant increase in infarct size (35.4 +/- 3.2% vs. 22.7 +/- 1.7% of ventricles in IH + sedenary and normoxia + sedentary groups, respectively, P < 0.05). HIT prevented both the IH-induced proapoptotic ER stress and increased myocardial infarct size (28.8 +/- 3.9% and 21.0 +/- 5.1% in IH + HIT and normoxia + HIT groups, respectively, P = 0.28). In conclusion, these findings suggest that HIT could represent a preventive strategy to limit IH-induced myocardial ischemia-reperfusion damages in OSA patients.
C1 [Bourdier, Guillaume; Flore, Patrice; Pepin, Jean-Louis; Belaidi, Elise; Arnaud, Claire] Grenoble Alpes Univ, Lab HP2, Grenoble, France.
   [Bourdier, Guillaume; Flore, Patrice; Pepin, Jean-Louis; Belaidi, Elise; Arnaud, Claire] INSERM, U1042, Grenoble, France.
   [Sanchez, Herve] Inst Rech Biomed Armees, Operat Environm, Bretigny Sur Orge, France.
C3 Communaute Universite Grenoble Alpes; Universite Grenoble Alpes (UGA);
   Institut National de la Sante et de la Recherche Medicale (Inserm)
RP Arnaud, C (corresponding author), Fac Med Pharm Grenoble, Inst Jean Roget, Lab HP2, BP 170, F-38042 Grenoble 9, France.
EM claire.arnaud@ujf-grenoble.fr
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OI Pepin, Jean Louis/0000-0003-3832-2358; Arnaud,
   Claire/0000-0003-0964-9423; FLORE, Patrice/0000-0002-6907-7853
FU Fond de Dotation (Agir pour les Maladies Chroniques)
FX This work was supported by the Fond de Dotation (Agir pour les Maladies
   Chroniques).
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NR 71
TC 46
Z9 49
U1 2
U2 18
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0363-6135
EI 1522-1539
J9 AM J PHYSIOL-HEART C
JI Am. J. Physiol.-Heart Circul. Physiol.
PD JAN 15
PY 2016
VL 310
IS 2
BP H279
EP H289
DI 10.1152/ajpheart.00448.2015
PG 11
WC Cardiac & Cardiovascular Systems; Physiology; Peripheral Vascular
   Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Physiology
GA DC2OS
UT WOS:000369056600013
PM 26566725
DA 2025-06-11
ER

PT J
AU Aleksic, A
   Trkulja, M
   Cikota-Aleksic, B
   Aleksic, D
AF Aleksic, Aleksandar
   Trkulja, Marijana
   Cikota-Aleksic, Bojana
   Aleksic, Dragan
TI Analysis of job stress in workers employed by three public organizations
   in Serbia
SO INTERNATIONAL JOURNAL OF OCCUPATIONAL MEDICINE AND ENVIRONMENTAL HEALTH
LA English
DT Article
DE Job Content Questionnaire; Job strain; Health-related problems
ID CORONARY-HEART-DISEASE; METABOLIC SYNDROME; RISK-FACTORS; CARDIOVASCULAR
   MORTALITY; PSYCHOSOCIAL STRESS; SOCIAL SUPPORT; SHIFT WORK; FOLLOW-UP;
   STRAIN; POPULATION
AB The present study analyzes job stress in terms of education, age and the presence of cardiovascular and endocrine/metabolic diseases.
   A total of 411 workers employed by three public organizations completed the Job Content Questionnaire to classify their jobs based on the job strain model. Data about health condition, education and habits was obtained by the use of medical examinations and an interview.
   The analysis of the completed Job Content Questionnaires indicates that workers with high education have significantly higher decision latitude (DL) than low-educated workers (one-way ANOVA, p < 0.0001). DL was also different between age groups (one-way ANOVA, p < 0.0001) - the highest DL values were observed in the oldest group, while the lowest DL mean was found in the youngest group. Psychological job demands (PJD) and social support (SS) were not significantly different between educational and age groups. The frequency of job stress categories was significantly different between low and highly-educated workers (chi(2) test, df = 3, p < 0.0001) and also between different age groups (chi(2) test, df = 6, p < 0.0001). The majority of highly-educated men were exposed to "active" jobs (high PJD and high DL). Most frequently, men older than 45 years experienced jobs with high DL ("active" and "low strain"), men aged 35 to 45 years were exposed to jobs with high PJD ("high strain" and "active") while the majority of men younger than 35 years were exposed to jobs with low DL ("high strain" and "passive"). No association between cardiovascular and endocrine/metabolic disorders and different job stress categories was observed.
   "High strain" and "passive" jobs were most frequently identified among low-educated and young men. Despite the absence of association between job stress and cardiovascular and endocrine/metabolic diseases, we recommend prevention of work stress, particularly in the case of low-educated workers and workers younger than 45 years exposed to unfavorable job stress categories.
C1 [Aleksic, Aleksandar; Aleksic, Dragan] Mil Med Acad, Inst Occupat Hlth, Belgrade 11000, Serbia.
   [Trkulja, Marijana] Inst Occupat Hlth, Belgrade, Serbia.
   [Cikota-Aleksic, Bojana] Mil Med Acad, Inst Med Res, Belgrade 11000, Serbia.
C3 University of Belgrade
RP Aleksic, A (corresponding author), Mil Med Acad, Inst Occupat Hlth, 17 Crnotravska, Belgrade 11000, Serbia.
EM aleksic.aleksandar7@gmail.com
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NR 36
TC 0
Z9 0
U1 0
U2 7
PU NOFER INST OCCUPATIONAL MEDICINE, POLAND
PI LODZ
PA SW TERESY 8, LODZ, 91-348, POLAND
SN 1232-1087
EI 1896-494X
J9 INT J OCCUP MED ENV
JI Int. J. Occup. Med. Environ. Health
PY 2013
VL 26
IS 3
BP 373
EP 382
DI 10.2478/s13382-013-0108-0
PG 10
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA 214BO
UT WOS:000324105500006
PM 23817867
OA gold
DA 2025-06-11
ER

PT J
AU Sabuhi, R
   Ali, Q
   Asghar, M
   Al-Zamily, NRH
   Hussain, T
AF Sabuhi, Rifat
   Ali, Quaisar
   Asghar, Mohammad
   Al-Zamily, Najah Riesh Hadi
   Hussain, Tahir
TI Role of the angiotensin II AT2 receptor in inflammation and
   oxidative stress: opposing effects in lean and obese Zucker rats
SO AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
LA English
DT Article
DE CGP-42112A; superoxide dismutase; TNF-alpha; IL-6; NF-kappa B; nitric
   oxide
ID TYPE-2 RECEPTOR; KAPPA-B; METABOLIC SYNDROME; NATRIURESIS; DYSFUNCTION;
   INHIBITION; SYSTEM
AB Sabuhi R, Ali Q, Asghar M, Al-Zamily NR, Hussain T. Role of the angiotensin II AT2 receptor in inflammation and oxidative stress: opposing effects in lean and obese Zucker rats. Am J Physiol Renal Physiol 300: F700-F706, 2011. First published January 5, 2011; doi:10.1152/ajprenal.00616.2010.-Inflammation and oxidative stress are believed to contribute to hypertension in obesity/diabetes. Recently, we reported a role for the AT2 receptor in blood pressure control in obese Zucker rats. However, the role of AT2 receptors in inflammation and oxidative stress in obesity is not known. Therefore, in the present study, we tested the effects of the AT2 receptor agonist CGP-42112A on inflammation and oxidative stress in obese Zucker rats and compared them in their lean counterparts. Rats were systemically treated with either vehicle (control) or CGP-42112A (1 mu g.kg(-1).min(-1); osmotic pump) for 2 wk. Markers of inflammation (CRP, MCP-1, TNF-alpha, and IL-6) and oxidative stress (HO-1, gp-91phox) as well as an antioxidant (SOD) were determined. Control obese rats had higher plasma levels of CRP, MCP-1, TNF-alpha, IL-6, and HO-1 compared with control lean rats. Conversely, plasma SOD activity was lower in control obese than in control lean rats. Furthermore, the protein levels of TNF-alpha and gp-91phox were higher in the kidney cortex of control obese rats. Interestingly, CGP-42112A treatment in obese rats reduced the plasma and kidney cortex inflammatory (TNF-alpha, IL-6) and oxidative stress (gp-91phox) markers and increased plasma SOD activity to the levels seen in lean control rats. However, CGP-42112A treatment in lean rats increased inflammatory (TNF-alpha, IL-6) and oxidative stress (gp-91phox) markers in the plasma and kidney cortex. Our present studies suggest anti-inflammatory and antioxidative functions of AT2 receptor in obese Zucker rats but proinflammatory and prooxidative functions in lean Zucker rats.
C1 [Sabuhi, Rifat; Ali, Quaisar; Asghar, Mohammad; Hussain, Tahir] Univ Houston, Dept Pharmacol & Pharmaceut Sci, Houston, TX 77204 USA.
   [Al-Zamily, Najah Riesh Hadi] Kufa Univ, Dept Pharmacol & Therapeut, Fac Med, Kufa, Iraq.
C3 University of Houston System; University of Houston; University of Kufa
RP Hussain, T (corresponding author), Univ Houston, Dept Pharmacol & Pharmaceut Sci, Sci & Res Bldg 2,4800 Calhoun, Houston, TX 77204 USA.
EM thussain2@uh.edu
RI Hussain, Tahir/LRV-2558-2024
OI Hussain, Tahir/0000-0002-6353-2317
FU National Institute of Diabetes and Digestive and Kidney Diseases
   [R01-DK-61578]
FX This study was supported by National Institute of Diabetes and Digestive
   and Kidney Diseases Grant R01-DK-61578.
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   Wu L, 2004, MOL ENDOCRINOL, V18, P666, DOI 10.1210/me.2003-0053
NR 46
TC 57
Z9 61
U1 0
U2 8
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 1931-857X
EI 1522-1466
J9 AM J PHYSIOL-RENAL
JI Am. J. Physiol.-Renal Physiol.
PD MAR
PY 2011
VL 300
IS 3
BP F700
EP F706
DI 10.1152/ajprenal.00616.2010
PG 7
WC Physiology; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology; Urology & Nephrology
GA 730ZS
UT WOS:000288076700014
PM 21209001
OA Green Published
DA 2025-06-11
ER

PT J
AU Miller, AL
   Kaciroti, N
   Sturza, J
   Retzloff, L
   Rosenblum, K
   Vazquez, DM
   Lumeng, JC
AF Miller, Alison L.
   Kaciroti, Niko
   Sturza, Julie
   Retzloff, Lauren
   Rosenblum, Katherine
   Vazquez, Delia M.
   Lumeng, Julie C.
TI Associations between stress biology indicators and overweight across
   toddlerhood
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE Child; Obesity; Stress; Cortisol; Salivary alpha-amylase (sAA);
   Low-income
ID SALIVARY ALPHA-AMYLASE; BODY-MASS INDEX; CARDIAC AUTONOMIC MODULATION;
   NERVOUS-SYSTEM ACTIVITY; CORTISOL-LEVELS; METABOLIC SYNDROME; DIURNAL
   CORTISOL; OBESE CHILDREN; AGED CHILDREN; US CHILDREN
AB Biological stress responses are proposed as a pathway through which stress exposure can "get under the skin" and lead to health problems, specifically obesity. Yet, it is not clear when such associations may emerge or whether they are bidirectional. Cortisol and salivary alpha amylase (sAA) were considered indicators of the biological stress response. We tested the longitudinal association between cortisol and sAA and weight in 215 low-income children at ages 21, 27, and 33 months (52% male; 46% non-Hispanic white). sAA and cortisol intercept and slope (representing morning level and rate of change across the day) were calculated for each age point using random effect models. Children were weighed and length measured and categorized as overweight versus normal weight (overweight defined as weight-for-length z-score >= 85th percentile for age and sex). Cross-lagged models stratified by sex and controlling for birth weight z-score tested the concurrent and cross-lagged associations between each of 4 indices of stress biology individually (cortisol and sAA intercept and slope) and overweight. Overweight status was correlated across time. Cortisol and sAA were correlated across occasions of measurement, though somewhat less strongly in boys. There were no concurrent associations between stress indicators and overweight. sAA at 27 months predicted greater risk of overweight at 33 months in girls, such that both lower sAA intercept and more rapidly increasing sAA at 27 months predicted greater risk of overweight at 33 months (beta=0.64, p<0.05 and (beta=1.09, p<0.05, respectively). For boys only, overweight at 21 months predicted lower sAA intercept at 27 months (beta=0.35, p<0.05). Findings suggest that longitudinal associations of stress biology and weight status may be present only on a limited basis very early in the lifespan. (C) 2017 Elsevier Ltd. All rights reserved.
C1 [Miller, Alison L.; Kaciroti, Niko; Sturza, Julie; Retzloff, Lauren; Rosenblum, Katherine; Vazquez, Delia M.; Lumeng, Julie C.] Univ Michigan, Ctr Human Growth & Dev, 300 North Ingalls St,10th Floor, Ann Arbor, MI 48109 USA.
   [Miller, Alison L.] Univ Michigan, Sch Publ Hlth, Dept Hlth Behav & Hlth Educ, Ann Arbor, MI 48109 USA.
   [Kaciroti, Niko; Vazquez, Delia M.] Univ Michigan, Sch Publ Hlth, Dept Biostat, Ann Arbor, MI 48109 USA.
   [Rosenblum, Katherine] Univ Michigan, Sch Med, Dept Psychiat, Ann Arbor, MI USA.
   [Vazquez, Delia M.; Lumeng, Julie C.] Univ Michigan, Sch Med, Dept Pediat, Ann Arbor, MI USA.
   [Lumeng, Julie C.] Univ Michigan, Sch Publ Hlth, Dept Nutr Sci, Ann Arbor, MI 48109 USA.
C3 University of Michigan System; University of Michigan; University of
   Michigan System; University of Michigan; University of Michigan System;
   University of Michigan; University of Michigan System; University of
   Michigan; University of Michigan System; University of Michigan;
   University of Michigan System; University of Michigan
RP Miller, AL (corresponding author), Univ Michigan, Ctr Human Growth & Dev, 300 North Ingalls St,10th Floor, Ann Arbor, MI 48109 USA.
EM alimill@umich.edu
RI Rosenblum, Katherine/AAC-5921-2019; Kaciroti, Niko/AAG-3988-2021
OI Miller, Alison/0000-0002-9866-0204; Vazquez, Delia/0000-0003-3621-4759;
   Rosenblum, Katherine/0000-0001-6952-9672
FU NICHD NIH HHS [R01 HD069179] Funding Source: Medline; NIDDK NIH HHS [P30
   DK020572] Funding Source: Medline; National Institute of Diabetes and
   Digestive and Kidney Diseases [P30DK020572] Funding Source: NIH RePORTER
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NR 60
TC 8
Z9 8
U1 0
U2 5
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD MAY
PY 2017
VL 79
BP 98
EP 106
DI 10.1016/j.psyneuen.2017.02.013
PG 9
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA ET3TF
UT WOS:000400201700013
PM 28273588
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Takahashi, K
   Yamada, T
   Tsukita, S
   Kaneko, K
   Shirai, Y
   Munakata, Y
   Ishigaki, Y
   Imai, J
   Uno, K
   Hasegawa, Y
   Sawada, S
   Oka, Y
   Katagiri, H
AF Takahashi, Kei
   Yamada, Tetsuya
   Tsukita, Sohei
   Kaneko, Keizo
   Shirai, Yuta
   Munakata, Yuichiro
   Ishigaki, Yasushi
   Imai, Junta
   Uno, Kenji
   Hasegawa, Yutaka
   Sawada, Shojiro
   Oka, Yoshitomo
   Katagiri, Hideki
TI Chronic mild stress alters circadian expressions of molecular clock
   genes in the liver
SO AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
LA English
DT Article
DE stress; liver clock; metabolic disorders; hypothalamus-pituitary-adrenal
   axis
ID HIGH-FAT DIET; METABOLIC SYNDROME; PERIPHERAL-TISSUES; ADRENAL AXIS;
   RHYTHMS; BEHAVIOR; LEPTIN; BRAIN; MODEL; BASAL
AB Takahashi K, Yamada T, Tsukita S, Kaneko K, Shirai Y, Munakata Y, Ishigaki Y, Imai J, Uno K, Hasegawa Y, Sawada S, Oka Y, Katagiri H. Chronic mild stress alters circadian expressions of molecular clock genes in the liver. Am J Physiol Endocrinol Metab 304: E301-E309, 2013. First published December 4, 2012; doi:10.1152/ajpendo.00388.2012.-Chronic stress is well known to affect metabolic regulation. However, molecular mechanisms interconnecting stress response systems and metabolic regulations have yet to be elucidated. Various physiological processes, including glucose/lipid metabolism, are regulated by the circadian clock, and core clock gene dysregulation reportedly leads to metabolic disorders. Glucocorticoids, acting as end- effectors of the hypothalamus-pituitary-adrenal (HPA) axis, entrain the circadian rhythms of peripheral organs, including the liver, by phase-shifting core clock gene expressions. Therefore, we examined whether chronic stress affects circadian expressions of core clock genes and metabolism-related genes in the liver using the chronic mild stress (CMS) procedure. In BALB/c mice, CMS elevated and phase-shifted serum corticosterone levels, indicating overactivation of the HPA axis. The rhythmic expressions of core clock genes, e.g., Clock, Npas2, Bmal1, Per1, and Cry1, were altered in the liver while being completely preserved in the hypothalamic suprachiasmatic nuculeus (SCN), suggesting that the SCN is not involved in alterations in hepatic core clock gene expressions. In addition, circadian patterns of glucose and lipid metabolism-related genes, e.g., peroxisome proliferator activated receptor (Ppar) alpha, Ppar gamma-1, Ppar gamma-coactivator-1 alpha, and phosphoenolepyruvate carboxykinase, were also disturbed by CMS. In contrast, in C57BL/6 mice, the same CMS procedure altered neither serum corticosterone levels nor rhythmic expressions of hepatic core clock genes and metabolism-related genes. Thus, chronic stress can interfere with the circadian expressions of both core clock genes and metabolism-related genes in the liver possibly involving HPA axis overactivation. This mechanism might contribute to metabolic disorders in stressful modern societies.
C1 [Takahashi, Kei; Yamada, Tetsuya; Tsukita, Sohei; Shirai, Yuta; Munakata, Yuichiro; Katagiri, Hideki] Tohoku Univ, Dept Metab Dis, Ctr Metab Dis, Grad Sch Med, Sendai, Miyagi 9808575, Japan.
   [Takahashi, Kei; Tsukita, Sohei; Kaneko, Keizo; Shirai, Yuta; Munakata, Yuichiro; Ishigaki, Yasushi; Imai, Junta; Uno, Kenji; Hasegawa, Yutaka; Sawada, Shojiro; Oka, Yoshitomo] Tohoku Univ, Div Mol Metab & Diabet, Grad Sch Med, Sendai, Miyagi 9808575, Japan.
C3 Tohoku University; Tohoku University
RP Yamada, T (corresponding author), Tohoku Univ, Dept Metab Dis, Ctr Metab Dis, Grad Sch Med,Aoba Ku, 2-1 Seiryo Machi, Sendai, Miyagi 9808575, Japan.
EM yamatetsu-tky@umin.ac.jp
RI Imai, Junta/NFG-4543-2025
FU Japan Society for the Promotion of Science [23591293, B2, 15390282];
   Global-COE from the Ministry of Education, Culture, Sports, Science and
   Technology of Japan; Grants-in-Aid for Scientific Research [23390238,
   22126006, 15390282, 24659439, 23791011, 23591293, 23591294] Funding
   Source: KAKEN
FX This work was supported by Grants-in-aid for Scientific Research (C,
   23591293 to T. Yamada and B2, 15390282 to H. Katagiri) from the Japan
   Society for the Promotion of Science. This work was also supported by
   Global-COE (H. Katagiri and Y. Oka) from the Ministry of Education,
   Culture, Sports, Science and Technology of Japan.
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NR 56
TC 47
Z9 52
U1 1
U2 20
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0193-1849
EI 1522-1555
J9 AM J PHYSIOL-ENDOC M
JI Am. J. Physiol.-Endocrinol. Metab.
PD FEB
PY 2013
VL 304
IS 3
BP E301
EP E309
DI 10.1152/ajpendo.00388.2012
PG 9
WC Endocrinology & Metabolism; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Physiology
GA 085SH
UT WOS:000314634100006
PM 23211520
DA 2025-06-11
ER

PT J
AU Edward, OC
   Thomas, SS
   Cha, KO
   Jung, HA
   Han, AN
   Cha, YS
AF Edward, Olivet Chiamaka
   Thomas, Shalom Sara
   Cha, Kyung-Ok
   Jung, Hyun-Ah
   Han, Anna
   Cha, Youn-Soo
TI Green perilla leaf extract ameliorates long-term oxidative stress
   induced by a high-fat diet in aging mice
SO NUTRITION RESEARCH AND PRACTICE
LA English
DT Article
DE Aging; oxidative stress; antioxidant; high-fat diet; perilla
ID ROSMARINIC ACID; ANTIOXIDANT ACTIVITY; FLAVONOID CONTENT; AQUEOUS
   EXTRACT; FRUTESCENS; SUPPLEMENTATION; SOLVENT; OBESITY; LEAVES; DAMAGE
AB BACKGROUND/OBJECTIVES: Oxidative stress is caused by an imbalance between harmful free radicals and antioxidants. Long-term oxidative stress can lead to an "exhausted" status of antioxidant defense system triggering development of metabolic syndrome and chronic inflammation. Green perilla (Perilla frutescens) is commonly used in Asian cuisines and traditional medicine in southeast Asia. Green perilla possesses numerous beneficial effects including anti-inflammatory and antioxidant functions. To investigate the potentials of green perilla leaf extract (PE) on oxidative stress, we induced oxidative stress by high-fat diet (HFD) in aging mice.MATERIALS/METHODS: C57BL/6J male mice were fed HFD continuously for 53 weeks. Then, mice were divided into three groups for 12 weeks: a normal diet fed reference group (NDcon), high-fat diet fed group (HDcon), and high-fat diet PE treated group (HDPE, 400 mg/kg of body weight). Biochemical analyses of serum and liver tissues were performed to assess metabolic and inflammatory damage and oxidative status. Hepatic gene expression of oxidative stress and inflammation related enzymes were evaluated by quantitative real-time polymerase chain reaction (qRT-PCR).RESULTS: PE improved hepatopathology. PE also improved the lipid profiles and antioxidant enzymes, including hepatic glutathione peroxidase (GPx) and superoxide dismutase (SOD) and catalase (CAT) in serum and liver. Hepatic gene expressions of antioxidant and anti-inflammatory related enzymes, such as SOD-1, CAT, interleukin 4 (IL-4) and nuclear factor erythroid 2-related factor (Nrf2) were significantly enhanced by PE. PE also reduced the levels of hydrogen peroxide (H2O2) and malondialdehyde (MDA) in the serum and liver; moreover, PE suppressed hepatic gene expression involved in pro-inflammatory response; Cyclooxygenase-2 (COX-2), nitric oxide synthase (NOS), interleukin 1 beta (IL-1 beta), and interleukin 6 (IL-6).CONCLUSIONS: This research opens opportunities for further investigations of PE as a functional food and possible anti-aging agent due to its attenuative effects against oxidative stress, resulting from HFD and aging in the future.
C1 [Edward, Olivet Chiamaka; Jung, Hyun-Ah; Han, Anna; Cha, Youn-Soo] Jeonbuk Natl Univ, Dept Food Sci & Human Nutr, Jeonju 54896, South Korea.
   [Thomas, Shalom Sara] Univ Massachusetts, Dept Nutr, Amherst, MA 01007 USA.
   [Cha, Kyung-Ok] Wanju Cty Off, Food & Policy Div, Wonju 55352, South Korea.
   [Han, Anna; Cha, Youn-Soo] Jeonbuk Natl Univ, K Food Res Ctr, Jeonju 54896, South Korea.
   [Cha, Youn-Soo] Jeonbuk Natl Univ, Dept Food Sci & Human Nutr, 567 Baekje Daero, Jeonju 54896, Guam, South Korea.
C3 Jeonbuk National University; University of Massachusetts System;
   University of Massachusetts Amherst; Jeonbuk National University;
   Jeonbuk National University
RP Cha, YS (corresponding author), Jeonbuk Natl Univ, Dept Food Sci & Human Nutr, 567 Baekje Daero, Jeonju 54896, Guam, South Korea.
EM cha8@jbnu.ac.kr
RI Park, Jinkyeong/GLV-1649-2022
OI Edward, Olivet Chiamaka/0000-0003-4794-5688; Thomas, Shalom
   Sara/0000-0003-1198-3690
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NR 51
TC 3
Z9 3
U1 4
U2 14
PU KOREAN NUTRITION SOC
PI SEOUL
PA 804 KST CTR, 635-4 YEOGSAM-SONG KANGNAM-KU, SEOUL, 135-703, SOUTH KOREA
SN 1976-1457
EI 2005-6168
J9 NUTR RES PRACT
JI Nutr. Res. Pract.
PD OCT
PY 2022
VL 16
IS 5
BP 549
EP 564
DI 10.4162/nrp.2022.16.5.549
PG 16
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 5C1UA
UT WOS:000864050800001
PM 36238378
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Kopustinskiene, DM
   Savickas, A
   Vetchy, D
   Masteikova, R
   Kasauskas, A
   Bernatoniene, J
AF Kopustinskiene, Dalia M.
   Savickas, Arunas
   Vetchy, David
   Masteikova, Ruta
   Kasauskas, Arturas
   Bernatoniene, Jurga
TI Direct Effects of (-)-Epicatechin and Procyanidin B2 on the Respiration
   of Rat Heart Mitochondria
SO BIOMED RESEARCH INTERNATIONAL
LA English
DT Article
ID FLAVANOL (-)-EPICATECHIN; OXIDATIVE STRESS; RICH COCOA; EPICATECHIN;
   ISCHEMIA; ANTIOXIDANT; FLAVONOIDS; PROTECTION; INJURY; OXYGEN
AB Flavonol (-)-epicatechin and its derived dimer procyanidin B2, present in high amounts in cocoa products, have been shown to exert beneficial effects on the heart and cardiovascular system; however, their mechanism of action has not been fully elucidated. We studied effects of (-)-epicatechin and procyanidin B2 on the oxidative phosphorylation of isolated rat heart mitochondria. (-)-Epicatechin and procyanidin B2 had stimulating effect (up to 30% compared to control) on substrate-driven (State 2) mitochondrial respiration. Their effect was dependent on the respiratory substrates used. (-)-Epicatechin at higher concentrations (from 0.27 mu g/mL) significantly decreased (up to 15%) substrate-and ADP-driven (State 3) mitochondrial respiration in case of pyruvate and malate oxidation only. Procyanidin B2 (0.7-17.9 ng/mL) inhibited State 3 respiration rate up to 19%, the most profound effect being expressed with succinate as the substrate. (-)-Epicatechin at concentrations of 0.23 mu g/mL and 0.46 mu g/mL prevented loss of the cytochrome.. from mitochondria when substrate was succinate, supporting the evidence of membrane stabilizing properties of this flavonol. Thus, both (-)-epicatechin and procyanidin B2 directly influenced mitochondrial functions and the observed effects could help to explain cardiometabolic risk reduction ascribed to the consumption of modest amounts of cocoa products.
C1 [Kopustinskiene, Dalia M.; Savickas, Arunas; Bernatoniene, Jurga] Lithuanian Univ Hlth Sci, Med Acad, Dept Pharmaceut Technol & Social Pharm, LT-50161 Kaunas, Lithuania.
   [Vetchy, David; Masteikova, Ruta] Univ Vet & Pharmaceut Sci Brno, Dept Pharmaceut, Brno 61242, Czech Republic.
   [Kasauskas, Arturas] Lithuanian Univ Hlth Sci, Med Acad, Dept Biochem, LT-44307 Kaunas, Lithuania.
C3 Lithuanian University of Health Sciences; University of Veterinary
   Sciences Brno; Lithuanian University of Health Sciences
RP Bernatoniene, J (corresponding author), Lithuanian Univ Hlth Sci, Med Acad, Dept Pharmaceut Technol & Social Pharm, Eiveniu 4, LT-50161 Kaunas, Lithuania.
EM jurgabernatoniene@yahoo.com
RI Bernatoniene, Jurga/JUV-0714-2023; Masteikova, Ruta/ABD-6125-2020
OI Masteikova, Ruta/0000-0002-5649-0307; Kopustinskiene, Dalia
   Marija/0000-0002-3399-2849
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NR 37
TC 31
Z9 33
U1 0
U2 11
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2314-6133
EI 2314-6141
J9 BIOMED RES INT
JI Biomed Res. Int.
PY 2015
VL 2015
AR 232836
DI 10.1155/2015/232836
PG 7
WC Biotechnology & Applied Microbiology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Research & Experimental Medicine
GA CD5AH
UT WOS:000351098300001
PM 25811024
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

EF﻿FN Clarivate Analytics Web of Science
VR 1.0
PT J
AU Gaudiano, BA
   Holst, CG
   Morena, A
   Reeves, LE
   Sydnor, VJ
   Epstein-Lubow, G
   Weinstock, LM
AF Gaudiano, Brandon A.
   Holst, Carolina Guzman
   Morena, Alexandra
   Reeves, Lauren E.
   Sydnor, Valerie J.
   Epstein-Lubow, Gary
   Weinstock, Lauren M.
TI Complex Polypharmacy in Patients With Schizophrenia-Spectrum Disorders
   Before a Psychiatric Hospitalization Prescribing Patterns and
   Associated Clinical Features
SO JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
LA English
DT Article
DE schizophrenia; polypharmacy; psychiatric hospitalization; medical
   illness
ID ANTIPSYCHOTIC POLYPHARMACY; METABOLIC SYNDROME; PSYCHOTROPIC
   MEDICATIONS; BIPOLAR DISORDER; MORTALITY; INPATIENT; DISCHARGE;
   OUTCOMES; THERAPY; ILLNESS
AB Background: Current evidence-based guidelines provide unclear support for many common polypharmacy practices in schizophrenia. Excessive or complex polypharmacy (>= 4 psychotropics) has been studied in patients with bipolar disorder, but not in schizophrenia to date.
   Methods: We conducted a digital medical record data extraction of 829 patients consecutively admitted to a psychiatric hospital and diagnosed as having schizophrenia-spectrum disorders.
   Results: In those prescribed psychiatric medication preadmission, 28.1% (n = 169) met the criteria for complex polypharmacy. Complex polypharmacy patients were older, female, white, and disabled, and had more comorbidities compared with those without complex polypharmacy. In multivariable analysis, complex polypharmacy was specifically associated with being white and disabled, and having a comorbid anxiety disorder, tobacco use disorder, metabolic condition, and neurological condition compared with noncomplex polypharmacy patients.
   Conclusions: Although there is little evidence to support complex polypharmacy in schizophrenia, rates were relatively high in patients requiring hospitalization, especially when they are also diagnosed as having comorbid psychiatric and medical conditions. Future research is needed to study the risk-benefit profile for these patients, especially considering their higher medical burden and related health risks.
C1 [Gaudiano, Brandon A.; Holst, Carolina Guzman; Morena, Alexandra; Reeves, Lauren E.; Sydnor, Valerie J.; Epstein-Lubow, Gary; Weinstock, Lauren M.] Butler Hosp, Psychosocial Res Program, Providence, RI 02906 USA.
   [Gaudiano, Brandon A.; Holst, Carolina Guzman; Reeves, Lauren E.; Sydnor, Valerie J.; Epstein-Lubow, Gary; Weinstock, Lauren M.] Brown Univ, Dept Psychiat & Human Behav, Warren Alpert Med Sch, Providence, RI 02912 USA.
C3 Butler Hospital Rhode Island; Brown University
RP Gaudiano, BA (corresponding author), Butler Hosp, 345 Blackstone Blvd, Providence, RI 02906 USA.
EM Brandon_Gaudiano@brown.edu
RI Gaudiano, Brandon/MZQ-6750-2025
OI Sydnor, Valerie/0000-0002-8640-668X; Morena,
   Alexandra/0000-0001-6151-0790; Guzman Holst,
   Carolina/0000-0002-5023-1726
CR [Anonymous], PRIM CARE COMPANION
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NR 59
TC 9
Z9 9
U1 0
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0271-0749
EI 1533-712X
J9 J CLIN PSYCHOPHARM
JI J. Clin. Psychopharmacol.
PD JUN
PY 2018
VL 38
IS 3
BP 180
EP 187
DI 10.1097/JCP.0000000000000876
PG 8
WC Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Pharmacology & Pharmacy; Psychiatry
GA GE1UE
UT WOS:000431001500004
PM 29620698
DA 2025-06-11
ER

PT J
AU Grindler, NM
   Santoro, NF
AF Grindler, Natalia M.
   Santoro, Nanette F.
TI Menopause and exercise
SO MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY
LA English
DT Review
DE Exercise; Menopause; Physical fitness
ID QUALITY-OF-LIFE; OBESE POSTMENOPAUSAL WOMEN; RANDOMIZED
   CONTROLLED-TRIAL; ELEVATED BLOOD-PRESSURE; BONE-MINERAL DENSITY;
   PHYSICAL-ACTIVITY; OLDER-ADULTS; WAIST CIRCUMFERENCE; METABOLIC
   SYNDROME; VASCULAR FUNCTION
AB Objective: Accumulating data suggest that regular physical exercise reduces mortality and extends the functional life span of men and women. This review seeks to describe the current state of the medical literature on this topic.
   Methods: A narrative review of the current medical literature including randomized clinical trials and clinical guidelines that address the benefits of physical fitness and regular exercise on the health of midlife and postmenopausal women.
   Results: Reduction and avoidance of obesity and its related comorbidities (hypertension, glucose intolerance, dyslipidemia, and heart disease) are one major benefit of exercise. However, long-term physical exercise is also associated with reduced rates of cancer, dementia and cognitive decline, adverse mood and anxiety symptoms, and reduction of osteoporosis, osteopenia, falls, and fractures. Beneficial physical activity includes exercise that will promote cardiovascular fitness (aerobic), muscle strength (resistance), flexibility (stretching), and balance (many of the preceding, and additional activities such as yoga).
   Conclusions: Given that it is unambiguously beneficial, inexpensive, and minimal risk, maintaining a healthy exercise regimen should be a goal for every participant to enhance lifelong wellness. Clinicians should use a number of behavioral strategies to support the physical fitness goals of their participants.
C1 [Grindler, Natalia M.; Santoro, Nanette F.] Univ Colorado, Div Reprod Endocrinol & Infertil, Dept Obstet & Gynecol, Sch Med, 12631 E 17th Ave, Aurora, CO 80045 USA.
C3 University of Colorado System; University of Colorado Anschutz Medical
   Campus
RP Santoro, NF (corresponding author), Univ Colorado, Div Reprod Endocrinol & Infertil, Dept Obstet & Gynecol, Sch Med, 12631 E 17th Ave, Aurora, CO 80045 USA.
EM Nanette.santoro@ucdenver.edu
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NR 100
TC 59
Z9 66
U1 2
U2 74
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1072-3714
EI 1530-0374
J9 MENOPAUSE
JI Menopause-J. N. Am. Menopause Soc.
PD DEC
PY 2015
VL 22
IS 12
BP 1351
EP 1358
DI 10.1097/GME.0000000000000536
PG 8
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Obstetrics & Gynecology
GA DD4JO
UT WOS:000369888500015
PM 26382311
DA 2025-06-11
ER

PT J
AU da Silva, IO
   de Menezes, NK
   Jacobina, HD
   Parra, AC
   Souza, FL
   Castro, LC
   Roelofs, J
   Tammaro, A
   Gomes, SA
   Sanches, TR
   Andrade, L
AF da Silva, Igor Oliveira
   de Menezes, Nicole K.
   Jacobina, Heloisa D.
   Parra, Antonio Carlos
   Souza, Felipe Lima
   Castro, Leticia Cardoso
   Roelofs, Joris
   Tammaro, Alessandra
   Gomes, Samirah Abreu
   Sanches, Talita Rojas
   Andrade, Lucia
TI Obesity aggravates acute kidney injury resulting from ischemia and
   reperfusion in mice
SO SCIENTIFIC REPORTS
LA English
DT Article
ID OXIDATIVE STRESS; METABOLIC SYNDROME; KLOTHO EXPRESSION; PROTEIN; AKI
AB In critically ill patients, overweight and obesity are associated with acute respiratory distress syndrome and acute kidney injury (AKI). However, the effect of obesity on ischemia-reperfusion injury (IRI)-induced AKI is unknown. We hypothesized that obesity would aggravate renal IRI in mice. We fed mice a standard or high-fat diet for eight weeks. The mice were divided into four groups and submitted to sham surgery or IRI: obese, normal, normal + IRI, obese, and obese + IRI. All studies were performed 48 h after the procedures. Serum glucose, cholesterol, and creatinine clearance did not differ among the groups. Survival and urinary osmolality were lower in the obese + IRI group than in the normal + IRI group, whereas urinary neutrophil gelatinase-associated lipocalin levels, tubular injury scores, and caspase 3 expression were higher. Proliferating cell nuclear antigen expression was highest in the obese + IRI group, as were the levels of oxidative stress (urinary levels of thiobarbituric acid-reactive substances and renal heme oxygenase-1 protein expression), whereas renal Klotho protein expression was lowest in that group. Expression of glutathione peroxidase 4 and peroxiredoxin 6, proteins that induce lipid peroxidation, a hallmark of ferroptosis, was lower in the obese + IRI group. Notably, among the mice not induced to AKI, macrophage infiltration was greater in the obese group. In conclusion, greater oxidative stress and ferroptosis might aggravate IRI in obese individuals, and Klotho could be a therapeutic target in those with AKI.
C1 [da Silva, Igor Oliveira; de Menezes, Nicole K.; Jacobina, Heloisa D.; Parra, Antonio Carlos; Castro, Leticia Cardoso; Sanches, Talita Rojas; Andrade, Lucia] Univ Sao Paulo, Sch Med, Div Nephrol, Lab Basic Sci Renal Dis LIM 12, Sao Paulo, Brazil.
   [Souza, Felipe Lima; Gomes, Samirah Abreu] Univ Sao Paulo, Div Nephrol, Sch Med, Lab Cellular Genet & Mol Nephrol, Ave Dr Arnaldo 455,3 Andar,Sala 3310, BR-01246903 Sao Paulo, SP, Brazil.
   [Roelofs, Joris; Tammaro, Alessandra] Univ Amsterdam, Amsterdam UMC, Dept Pathol, Locat AMC, Amsterdam, Netherlands.
C3 Universidade de Sao Paulo; Universidade de Sao Paulo; University of
   Amsterdam
RP Andrade, L (corresponding author), Univ Sao Paulo, Sch Med, Div Nephrol, Lab Basic Sci Renal Dis LIM 12, Sao Paulo, Brazil.
EM lucia.andrade@fm.usp.br
RI Sanches, Talita/A-2953-2015; SOUZA, FELIPE/HPH-0340-2023; GOMES,
   SAMIRAH/ABG-6668-2020
OI Tammaro, Alessandra/0000-0003-3128-5259
FU Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP, Sao Paulo
   Research Foundation) [2020/12278-7]; Laboratorios de Investigacao Medica
   (Medical Investigation Laboratories) of the Faculdade de Medicina da
   Universidade de Sao Paulo (University of Sao Paulo School of Medicine);
   Brazilian National Coordenacao de Aperfeicoamento de Pessoal de Nivel
   Superior (CAPES, Office for the Advancement of Higher Education)
   [88887.461455/2019-00]; Brazilian Conselho Nacional de Desenvolvimento
   Cientifico e Tecnologico (National Council for Scientific and
   Technological Development) [309683/2021-1]; FAPESP [2018/23182-0,
   2018/23183-7, 2022/11975-1]
FX This work was supported by the Fundacao de Amparo a Pesquisa do Estado
   de Sao Paulo (FAPESP, Sao Paulo Research Foundation; Grant no.
   2020/12278-7) and by the Laboratorios de Investigacao Medica (Medical
   Investigation Laboratories) of the Faculdade de Medicina da Universidade
   de Sao Paulo (University of Sao Paulo School of Medicine). I.O.S is the
   recipient of a grant from the Brazilian National Coordenacao de
   Aperfeicoamen to de Pessoal de Nivel Superior (CAPES, Office for the
   Advancement of Higher Education; Grant no. 88887.461455/2019-00). L. A.
   is the recipient of a grant from the Brazilian Conselho Nacional de
   Desenvolvimento Cientifico e Tecnologico (National Council for
   Scientific and Technological Development; Grant 309683/2021-1). N.K.M.,
   H.D.J., and A.C.P. are the recipients of grants from FAPESP (Grant nos.
   2018/23182-0, 2018/23183-7, and 2022/11975-1, respectively). Editorial
   assistance was provided by Jefferson Davis Boyles, ELS.
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NR 40
TC 2
Z9 2
U1 0
U2 5
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD APR 29
PY 2024
VL 14
IS 1
AR 9820
DI 10.1038/s41598-024-60365-3
PG 11
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA PA2L7
UT WOS:001211293200111
PM 38684767
OA gold, Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Anderson, EJ
   Vistoli, G
   Katunga, LA
   Funai, K
   Regazzoni, L
   Monroe, TB
   Gilardoni, E
   Cannizzaro, L
   Colzani, M
   De Maddis, D
   Rossoni, G
   Canevotti, R
   Gagliardi, S
   Carini, M
   Aldini, G
AF Anderson, Ethan J.
   Vistoli, Giulio
   Katunga, Lalage A.
   Funai, Katsuhiko
   Regazzoni, Luca
   Monroe, T. Blake
   Gilardoni, Ettore
   Cannizzaro, Luca
   Colzani, Mara
   De Maddis, Danilo
   Rossoni, Giuseppe
   Canevotti, Renato
   Gagliardi, Stefania
   Carini, Marina
   Aldini, Giancarlo
TI A carnosine analog mitigates metabolic disorders of obesity by reducing
   carbonyl stress
SO JOURNAL OF CLINICAL INVESTIGATION
LA English
DT Article
ID GLYCATION END-PRODUCTS; GLUTATHIONE-PEROXIDASE 4; LIPID-PEROXIDATION;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; SKELETAL-MUSCLE; PROTEIN
   CARBONYLATION; DISEASE; DIET; GENE
AB Sugar- and lipid-derived aldehydes are reactive carbonyl species (RCS) frequently used as surrogate markers of oxidative stress in obesity. A pathogenic role for RCS in metabolic diseases of obesity remains controversial, however, partly because of their highly diffuse and broad reactivity and the lack of specific RCS-scavenging therapies. Naturally occurring histidine dipeptides (e.g., anserine and carnosine) show RCS reactivity, but their therapeutic potential in humans is limited by serum carnosinases. Here, we present the rational design, characterization, and pharmacological evaluation of carnosinol, i.e., (2S)-2-(3-aminopropanoylamino)-3-(1H-imidazol-5-yl)propanol, a derivative of carnosine with high oral bioavailability that is resistant to carnosinases. Carnosinol displayed a suitable ADMET (absorption, distribution, metabolism, excretion, and toxicity) profile and was determined to have the greatest potency and selectivity toward alpha,beta-unsaturated aldehydes (e.g., 4-hydroxynonenal, HNE, ACR) among all others reported thus far. In rodent models of diet-induced obesity and metabolic syndrome, carnosinol dose-dependently attenuated HNE adduct formation in liver and skeletal muscle, while simultaneously mitigating inflammation, dyslipidemia, insulin resistance, and steatohepatitis. These improvements in metabolic parameters with carnosinol were not due to changes in energy expenditure, physical activity, adiposity, or body weight. Collectively, our findings illustrate a pathogenic role for RCS in obesity-related metabolic disorders and provide validation for a promising new class of carbonyl-scavenging therapeutic compounds rationally derived from carnosine.
C1 [Anderson, Ethan J.; Monroe, T. Blake] Univ Iowa, Dept Pharmaceut Sci & Expt Therapeut, Coll Pharm, Fraternal Order Eagles Diabet Res Ctr, 115 S Grand Ave, Iowa City, IA 52242 USA.
   [Anderson, Ethan J.; Katunga, Lalage A.; Monroe, T. Blake] East Carolina Univ, Dept Pharmacol & Toxicol, Greenville, NC 27858 USA.
   [Vistoli, Giulio; Regazzoni, Luca; Gilardoni, Ettore; Cannizzaro, Luca; Colzani, Mara; De Maddis, Danilo; Carini, Marina; Aldini, Giancarlo] Univ Milan, Dept Pharmaceut Sci, Via Mangiagalli 25, I-20133 Milan, Italy.
   [Funai, Katsuhiko] Univ Utah, Diabet & Metab Res Ctr, Salt Lake City, UT USA.
   [Rossoni, Giuseppe] Univ Milan, Dept Med Biotechnol & Translat Med, Milan, Italy.
   [Canevotti, Renato; Gagliardi, Stefania] Flamma SpA, Bergamo, Italy.
C3 University of Iowa; University of North Carolina; East Carolina
   University; University of Milan; Utah System of Higher Education;
   University of Utah; University of Milan
RP Anderson, EJ (corresponding author), Univ Iowa, Dept Pharmaceut Sci & Expt Therapeut, Coll Pharm, Fraternal Order Eagles Diabet Res Ctr, 115 S Grand Ave, Iowa City, IA 52242 USA.; Aldini, G (corresponding author), Univ Milan, Dept Pharmaceut Sci, Via Mangiagalli 25, I-20133 Milan, Italy.
EM ethan-anderson@uiowa.edu; giancarlo.aldini@unimi.it
RI Gilardoni, Ettore/AAH-1864-2020; aldini, giancarlo/C-3533-2013;
   Regazzoni, Luca/D-4212-2014
OI Cannizzaro, Luca/0000-0001-9690-6306; Monroe, Blake/0000-0002-7146-0907;
   Regazzoni, Luca/0000-0001-7199-7141; Gilardoni,
   Ettore/0000-0002-2010-2667
FU Ministry of Education, Universities, and Research of Italy (MIUR) (PRIN
   2009); Regione Lombardia - MIUR [6737]; NIH [R01HL122863, R21AG057006]
FX Carnosinol was provided by Flamma S.p.A. This project was supported by
   funds from the Ministry of Education, Universities, and Research of
   Italy (MIUR) (PRIN 2009); the Regione Lombardia - MIUR (L.297-Art.
   12/BioTech DM27909 and decree no. 6737 July, 2, 2009); and the NIH
   (R01HL122863 and R21AG057006, to EJA). The authors would like to thank
   Cherese Beatty (East Carolina University), who assisted with animal
   experiments and tissue histology. GV gratefully acknowledges Concetta De
   Stefano (University of Messina, Messina, Italy) for assistance in
   determining the chelation constants.
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NR 76
TC 81
Z9 84
U1 3
U2 19
PU AMER SOC CLINICAL INVESTIGATION INC
PI ANN ARBOR
PA 2015 MANCHESTER RD, ANN ARBOR, MI 48104 USA
SN 0021-9738
EI 1558-8238
J9 J CLIN INVEST
JI J. Clin. Invest.
PD DEC 3
PY 2018
VL 128
IS 12
BP 5280
EP 5293
DI 10.1172/JCI94307
PG 14
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA HC8RH
UT WOS:000452071300016
PM 30226473
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Crujeiras, AB
   Parra, D
   Abete, I
   Martínez, JA
AF Crujeiras, Ana B.
   Parra, Dolores
   Abete, Itziar
   Alfredo Martinez, J.
TI A hypocaloric diet enriched in legumes specifically mitigates lipid
   peroxidation in obese subjects
SO FREE RADICAL RESEARCH
LA English
DT Article
DE obesity; oxidative stress; caloric restriction; lipid peroxidation;
   antioxidant status; dietary TAC
ID LOW-DENSITY-LIPOPROTEIN; INCREASED OXIDATIVE STRESS; TOTAL ANTIOXIDANT
   CAPACITY; SPECIES ROS GENERATION; INHIBITOR KAPPA-B; WEIGHT-LOSS;
   MONONUCLEAR-CELLS; IN-VIVO; ENDOTHELIAL FUNCTION; METABOLIC SYNDROME
AB Legume intake could specifically protect against lipid peroxidation in addition to the effects associated to weight loss when included in hypocaloric diets. Thus, 30 obese subjects ( age: 36 +/- 8 years and BMI: 32.0 +/- 5.3 kg/m(2)) were nutritionally treated by a 8-week energy restriction ( -30% energy expenditure) with a legume enriched diet ( 4 days/week servings, n = 15) or without legumes ( control diet ( CD), n = 15). Body weight, circulating cholesterol, oxidized LDL ( ox-LDL), malondialdehyde ( MDA) and urinary 8-isoprostane F-2 alpha ( 8-iso-PGF(2 alpha)) were measured at baseline and at endpoint. After the nutritional intervention, all obese subjects lost weight, specially those individuals who followed the legumes-enriched diet as compared to the CD ( -7.7 +/- 3 vs. - 5.3 +/- 2.7%; p = 0.023), which was accompanied by marked decreases in total cholesterol levels ( p < 0.001) and statistically significant diet-related reductions on plasma ox-LDL, plasma MDA and urinary 8-iso-PGF(2 alpha) output.
   Therefore, a balanced diet with moderate caloric restriction including 4 day/week legume servings empowered the oxidative stress improvement related to weight loss through a reduction in lipid peroxidation as compared to a control hypocaloric diet.
C1 Univ Navarra, Dept Physiol & Nutr, Pamplona 31008, Spain.
C3 University of Navarra
RP Martínez, JA (corresponding author), Univ Navarra, Dept Physiol & Nutr, C-Irunlarrea 1, Pamplona 31008, Spain.
EM jalfmtz@unav.es
RI Crujeiras, Ana B/ABA-8866-2021; Abete, Itziar/H-4827-2017; Martinez
   Hernandez, J Alfredo/K-8709-2014
OI Crujeiras, Ana B/0000-0003-4392-0301; Parra-Astorgano,
   Lola/0009-0008-1231-2884; Abete, Itziar/0000-0002-6475-5387; Martinez
   Hernandez, J Alfredo/0000-0001-5218-6941
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NR 55
TC 82
Z9 85
U1 1
U2 9
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1071-5762
EI 1029-2470
J9 FREE RADICAL RES
JI Free Radic. Res.
PY 2007
VL 41
IS 4
BP 498
EP 506
DI 10.1080/10715760601131935
PG 9
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 155PA
UT WOS:000245588900013
PM 17454132
DA 2025-06-11
ER

PT J
AU Mokgalaboni, K
   Ntamo, Y
   Ziqubu, K
   Nyambuya, TM
   Nkambule, BB
   Mazibuko-Mbeje, SE
   Gabuza, KB
   Chellan, N
   Tiano, L
   Dludla, P
AF Mokgalaboni, Kabelo
   Ntamo, Yonela
   Ziqubu, Khanyisani
   Nyambuya, Tawanda M.
   Nkambule, Bongani B.
   Mazibuko-Mbeje, Sithandiwe E.
   Gabuza, Kwazikwakhe B.
   Chellan, Nireshni
   Tiano, Luca
   Dludla, Phiwayinkosi, V
TI Curcumin supplementation improves biomarkers of oxidative stress and
   inflammation in conditions of obesity, type 2 diabetes and NAFLD:
   updating the status of clinical evidence
SO FOOD & FUNCTION
LA English
DT Review
ID TUMOR-NECROSIS-FACTOR; METABOLIC SYNDROME; BIOAVAILABLE CURCUMIN; ORAL
   BIOAVAILABILITY; CONTROLLED-TRIAL; ANTIOXIDANT; PIPERINE; PLACEBO;
   MARKERS; DISEASE
AB Oxidative stress and inflammation remain the major complications implicated in the development and progression of metabolic complications, including obesity, type 2 diabetes (T2D) and nonalcoholic fatty liver disease (NAFLD). In fact, due to their abundant antioxidant and anti-inflammatory properties, there is a general interest in understanding the therapeutic effects of some major food-derived bioactive compounds like curcumin against diverse metabolic diseases. Hence, a systematic search, through prominent online databases such as MEDLINE, Scopus, and Google Scholar was done focusing on randomized controlled trials (RCTs) reporting on the impact of curcumin supplementation in individuals with diverse metabolic complications, including obesity, T2D and NAFLD. Summarized findings suggest that curcumin supplementation can significantly reduce blood glucose and triglycerides levels, including markers of liver function like alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in patients with T2D and NAFLD. Importantly, this effect was consistent with the reduction of predominant markers of oxidative stress and inflammation, such as the levels of malonaldehyde (MDA), tumor necrosis factor-alpha (TNF-alpha), high sensitivity C-reactive protein (hs-CRP) and monocyte chemoattractant protein-1 (MCP-1) in these patients. Although RCTs suggest that curcumin is beneficial in ameliorating some metabolic complications, future research is still necessary to enhance its absorption and bioavailability profile, while also optimizing the most effective therapeutic doses.
C1 [Mokgalaboni, Kabelo; Nkambule, Bongani B.; Gabuza, Kwazikwakhe B.] Univ KwaZulu Natal, Sch Lab Med & Med Sci, ZA-4000 Durban, South Africa.
   [Ntamo, Yonela; Chellan, Nireshni; Dludla, Phiwayinkosi, V] South African Med Res Council, Biomed Res & Innovat Platform, ZA-7505 Tygerberg, South Africa.
   [Ziqubu, Khanyisani; Mazibuko-Mbeje, Sithandiwe E.] North West Univ, Dept Biochem, ZA-2745 Mmabatho, South Africa.
   [Nyambuya, Tawanda M.] Namibia Univ Sci & Technol, Dept Hlth Sci, Windhoek 9000, Namibia.
   [Chellan, Nireshni] Stellenbosch Univ, Fac Hlth Sci, Div Med Physiol, ZA-7505 Tygerberg, South Africa.
   [Tiano, Luca] Polytech Univ Marche, Dept Life & Environm Sci, I-60131 Ancona, Italy.
C3 University of Kwazulu Natal; South African Medical Research Council;
   North West University - South Africa; Namibia University of Science &
   Technology; Stellenbosch University; Marche Polytechnic University
RP Dludla, P (corresponding author), South African Med Res Council, Biomed Res & Innovat Platform, ZA-7505 Tygerberg, South Africa.
RI Nyambuya, Tawanda Maurice/GLU-4124-2022; Tiano, Luca/ABC-2341-2020;
   Nkambule, Bongani/ABD-7943-2022; Chellan, Nireshni/M-3037-2013;
   Mazibuko-Mbeje, Sithandiwe/HPG-1119-2023; Mokgalaboni,
   Kabelo/ACZ-1282-2022
OI Nyambuya, Tawanda Maurice/0000-0002-3288-9524; Nkambule,
   Bongani/0000-0001-8846-1992; Gabuza, Kwazi/0000-0003-0144-6664;
   Mokgalaboni, Kabelo/0000-0002-3224-7433; Dludla,
   Phiwayinkosi/0000-0001-5965-3610
FU National Research Foundation (NRF) [121496]; Department of Science and
   Technology (DST); NRF: Professional Development Programme Block Grant
   [128107]; South African Medical Research Council through its Division of
   Research Capacity Development under the Researcher Development Award
   Programme; NIH D43 grant [D43TW010131]; Biomedical Research and
   Innovation Platform of the South African Medical Research Council
   (SAMRC); National Research Foundation [132534, 117829]
FX K. M. is partially funded by the National Research Foundation (NRF),
   through the postgraduate bursary funding scheme (Grant number: 121496).
   Y. Ntamo is a postdoctoral research fellow, funded by the Department of
   Science and Technology (DST) and the NRF: Professional Development
   Programme Block Grant (Grant number: 128107). The work by K Ziqubu,
   reported herein was made possible through partial funding by the South
   African Medical Research Council through its Division of Research
   Capacity Development under the Researcher Development Award Programme.
   B. B. Nkambule is a University of KwaZulu-Natal Developing Research
   Innovation, Localisation and Leadership in South Africa (DRILL) fellow.
   DRILL is a NIH D43 grant (D43TW010131) awarded to UKZN in 2015 to
   support a research training and induction programme for early career
   academics. The content hereof is the sole responsibility of the authors
   and do not necessarily represent the official views of the funders, NRF
   or the SAMRC. Funding statement: This work was supported in part by
   baseline funding from the Biomedical Research and Innovation Platform of
   the South African Medical Research Council (SAMRC) and the National
   Research Foundation (Grant numbers: 132534 and 117829). The content
   hereof is the sole responsibility of the authors and do not necessarily
   represent the official views of the SAMRC or the funders.
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NR 137
TC 66
Z9 66
U1 5
U2 42
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PD DEC 13
PY 2021
VL 12
IS 24
BP 12235
EP 12249
DI 10.1039/d1fo02696h
EA NOV 2021
PG 15
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA XN5OW
UT WOS:000723833500001
PM 34847213
DA 2025-06-11
ER

PT J
AU Naz, MSG
   Tehrani, FR
   Behroozi-Lak, T
   Mohammadzadeh, F
   Badr, FK
   Ozgoli, G
AF Naz, Marzieh Saei Ghare
   Tehrani, Fahimeh Ramezani
   Behroozi-Lak, Tahereh
   Mohammadzadeh, Farnaz
   Badr, Farhnaz Kholosi
   Ozgoli, Giti
TI Polycystic Ovary Syndrome and Pelvic Floor Dysfunction: A Narrative
   Review
SO RESEARCH AND REPORTS IN UROLOGY
LA English
DT Review
DE pelvic floor; muscles; urinary stress incontinence; polycystic ovary
   syndrome
ID URINARY STRESS-INCONTINENCE; ORGAN PROLAPSE SURGERY; METABOLIC SYNDROME;
   ELECTROMYOGRAPHIC ACTIVITY; HORMONE-LEVELS; WOMEN; MUSCLE; ASSOCIATION;
   OBESITY; EPIDEMIOLOGY
AB Pelvic floor dysfunction is one of the most common disorders in women that is associated with social and economic consequences. In general, this disorder imposes direct and indirect costs on the economy of various societies. This review aimed to investigate pelvic floor dysfunction in women with polycystic ovary syndrome (PCOS). In this narrative review, the published articles on pelvic floor dysfunction were examined in PubMed, Scopus, Web of Sciences and Google Scholar. We searched for terms related to polycystic ovary syndrome and pelvic floor dysfunction. Inclusion criteria of this research were observational, experimental, and review studies. In this investigation, the complications associated with polycystic ovary syndrome were examined as risk factors for pelvic floor dysfunction. In this narrative review, we discuss about changes in hormone levels, obesity and overweight, hormonal medications and complications such as diabetes and metabolic disorders and obstetric complications of PCOS can be involved in the pathophysiology of pelvic floor dysfunctions, including stress urinary incontinence and pelvic organ prolapse in women with PCOS. This review highlights knowledge gaps about protective effect of hyperandrogenism on pelvic floor dysfunction as well as destructive effect of metabolic changes on pelvic floor dysfunction in women with PCOS. Further cohort and prospective studies are recommended in women with PCOS to investigate the concept of pelvic organ dysfunction in these women.
C1 [Naz, Marzieh Saei Ghare] Shahid Beheshti Univ Med Sci, Reprod Endocrinol Res Ctr, Res Inst Endocrine Sci, Student Res Comm, Tehran, Iran.
   [Tehrani, Fahimeh Ramezani] Shahid Beheshti Univ Med Sci, Reprod Endocrinol Res Ctr, Res Inst Endocrine Sci, Tehran, Iran.
   [Behroozi-Lak, Tahereh] Urmia Univ Med Sci, Reprod Hlth Res Ctr, Dept Infertil, Orumiyeh, Iran.
   [Mohammadzadeh, Farnaz; Badr, Farhnaz Kholosi] Shahid Beheshti Univ Med Sci, Sch Nursing & Midwifery, Dept Reprod Hlth, Tehran, Iran.
   [Ozgoli, Giti] Shahid Beheshti Univ Med Sci, Sch Nursing & Midwifery, Dept Midwifery & Reprod Hlth, Tehran, Iran.
C3 Shahid Beheshti University Medical Sciences; Shahid Beheshti University
   Medical Sciences; Urmia University of Medical Sciences; Shahid Beheshti
   University Medical Sciences; Shahid Beheshti University Medical Sciences
RP Ozgoli, G (corresponding author), Shahid Beheshti Univ Med Sci, Sch Nursing & Midwifery, Dept Midwifery & Reprod Hlth, Tehran, Iran.
EM gozgoli@gmail.com
RI behroozy-lak, tahereh/L-7173-2017; Naz, Marzieh/K-8811-2019; Tehrani,
   Fahimeh/H-6133-2017
OI Saei Ghare Naz, Marzieh/0000-0002-1259-2459
FU Student Research Committee, Shahid Beheshti University of Medical
   Sciences, Tehran, Iran [1397/71127]; "Student Research Committee" in
   Shahid Beheshti University of Medical Sciences; Shahid Beheshti
   University of Medical Sciences
FX This study is related to the project No. 1397/71127 From Student
   Research Committee, Shahid Beheshti University of Medical Sciences,
   Tehran, Iran. We also appreciate the "Student Research Committee" and
   "Research & Technology Chancellor" in Shahid Beheshti University of
   Medical Sciences for their financial support of this study.
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NR 77
TC 10
Z9 10
U1 3
U2 15
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 2253-2447
J9 RES REP UROL
JI RES. REP. UROL.
PY 2020
VL 12
BP 179
EP 185
DI 10.2147/RRU.S249611
PG 7
WC Urology & Nephrology
WE Emerging Sources Citation Index (ESCI)
SC Urology & Nephrology
GA LL5XJ
UT WOS:000531631700001
PM 32440514
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Ke, HH
   Bao, T
   Chen, W
AF Ke, Huihui
   Bao, Tao
   Chen, Wei
TI Polysaccharide from Rubus chingii Hu affords
   protection against palmitic acid-induced lipotoxicity in human
   hepatocytes
SO INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
LA English
DT Article
DE Palmitic acid; Lipotoxicity; Rubus chingii Hu; Polysaccharide;
   Structural characterization; Oxidative stress
ID GASTROINTESTINAL DIGESTION; STRUCTURAL-CHARACTERIZATION; MITOCHONDRIAL
   DYSFUNCTION; SYSTEMATIC EVALUATION; ANTIOXIDANT ACTIVITY; INDUCED
   CYTOTOXICITY; HYDROGEN-PEROXIDE; OXIDATIVE STRESS; MULBERRY; CELLS
AB Palmitic acid (PA) is known to induce lipotoxicity, a metabolic syndrome as a result of lipid accumulation in multiple cell lines. Bioactive phytochemicals derived from vegetables and fruits have gained increasing attention owing to their potential on suppressing the detrimental effect of excessive PA accumulation. However, the protective effect of natural phytochemicals derived from Rubus chingii Hu, a kind of fruit widely grown in China, against PA-induced lipotoxicity is still uncleared. in the present study, we therefore extracted the polysaccharide from Rubus chingii Hu, and identified its chemical structure. Structural characterization by HPLC, HPGPC, IR spectroscopy and GC indicated that the polysaccharide mainly consists of galacturonic acid and arabinose with copious 1 -> 2 glycosidic linkages in its backbone. In addition, our results showed the cytoprotective effect of the polysaccharide against PA-induced lipotoxicity in normal human hepatocyte cell line L02. Further study indicated that the polysaccharide mitigated oxidative stress through impeding cellular reactive oxygen species (ROS) accumulation, alleviating mitochondrial membrane potential (MMP) collapse and attenuating glutathione (GSH) reduction. Overall, this study revealed that Rubus chingii Hu polysaccharide was capable of effectively alleviating palmitic acid-induced lipotoxicity, which provided a novel perspective of the health-promoting potential of isolated polysaccharide. (C) 2019 Elsevier B.V. All rights reserved.
C1 [Ke, Huihui; Bao, Tao; Chen, Wei] Zhejiang Univ, Dept Food Sci & Nutr, Zhejiang Key Lab Agrofood Proc, Hangzhou 310058, Zhejiang, Peoples R China.
   [Chen, Wei] Zhejiang Univ, Ningbo Res Inst, Ningbo 315100, Zhejiang, Peoples R China.
C3 Zhejiang University; Zhejiang University
RP Chen, W (corresponding author), Zhejiang Univ, Dept Food Sci & Nutr, 866 Yuhangtang Rd, Hangzhou 310058, Zhejiang, Peoples R China.
EM zjuchenwei@zju.edu.cn
RI Chen, Wei/AAR-9817-2020
OI CHEN, WEI/0000-0002-2373-2437
FU National Natural Science Foundation of China [U1703105]; Zhejiang
   Provincial Natural Science Foundation of China [LR18C200002]
FX This work was supported by Grants from National Natural Science
   Foundation of China (U1703105), and Zhejiang Provincial Natural Science
   Foundation of China (LR18C200002).
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NR 44
TC 36
Z9 41
U1 2
U2 92
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0141-8130
EI 1879-0003
J9 INT J BIOL MACROMOL
JI Int. J. Biol. Macromol.
PD JUL 15
PY 2019
VL 133
BP 1063
EP 1071
DI 10.1016/j.ijbiomac.2019.04.176
PG 9
WC Biochemistry & Molecular Biology; Chemistry, Applied; Polymer Science
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry; Polymer Science
GA IE9HO
UT WOS:000472685700114
PM 31034903
DA 2025-06-11
ER

PT J
AU Hermoso, DAM
   Shimada, LBC
   Gilglioni, EH
   Constantin, J
   Mito, MS
   Hermoso, APM
   Salgueiro-Pagadigorria, CL
   Iwamoto, ELI
AF Munhos Hermoso, Danielle Aparecida
   Campos Shimada, Lilian Brites
   Gilglioni, Eduardo Hideo
   Constantin, Jorgete
   Mito, Marcio Shigueaki
   Munhos Hermoso, Aparecida Pinto
   Salgueiro-Pagadigorria, Clairce Luzia
   Ishii Iwamoto, Emy Luiza
TI Melatonin protects female rats against steatosis and liver oxidative
   stress induced by oestrogen deficiency
SO LIFE SCIENCES
LA English
DT Article
DE Melatonin; Ovariectomy; Obesity; Steatosis
ID MITOCHONDRIAL DYSFUNCTION; OVARIECTOMIZED RATS; TIME-COURSE; MECHANISMS;
   PURIFICATION; GLUTATHIONE; EXPRESSION; RECEPTORS; REDUCTASE; ENZYMES
AB Aims: Melatonin has been shown to protect cells against oxidative and inflammatory damage via endocrine, paracrine and autocrine actions. Postmenopausal condition is associated with a high incidence of many features of metabolic syndrome including obesity, steatosis and liver oxidative injuries. The aim of this work was to investigate whether treatment with melatonin improves metabolic disturbances associated with oestrogen deficiency in ovariectomised (OVX) rats.
   Main methods: OVX and control (CON) female rats were treated with melatonin (10 mg/kg x day for 3 weeks, p.o.). Body weight gain, adiposity index, plasma biochemical parameters, liver lipid content, hepatic mitochondrial respiration, fatty acid oxidation and mitochondrial H2O2 generation and the activity of the most important enzymatic and non-enzymatic reactive oxygen species (ROS) scavenger systems were measured.
   Key findings: In OVX rats, melatonin suppressed lipid accumulation and cellular oxidative stress in the liver. There was a reduction in the levels of carbonylated proteins in the mitochondria and cytosol, reduction in the malondialdehyde contents in the liver homogenates, stimulation of cytosolic glutathione peroxidase and glutathione reductase activities and restoration of reduced glutathione contents to normal levels.
   Significance: Exogenous melatonin protects the liver of OVX rats against steatosis and cellular oxidative stress, possibly via activation of antioxidant enzymes related to glutathion emetabolism and by a direct radical scavenging activity. (C) 2016 Elsevier Inc. All rights reserved.
C1 [Munhos Hermoso, Danielle Aparecida; Campos Shimada, Lilian Brites; Gilglioni, Eduardo Hideo; Constantin, Jorgete; Mito, Marcio Shigueaki; Munhos Hermoso, Aparecida Pinto; Ishii Iwamoto, Emy Luiza] Univ Maringa, Lab Biol Oxidat, Dept Biochem, BR-87020900 Maringa, Parana, Brazil.
   [Salgueiro-Pagadigorria, Clairce Luzia] Univ Maringa, Dept Physiol Sci, BR-87020900 Maringa, Parana, Brazil.
   [Campos Shimada, Lilian Brites] Ctr Educ Integrado, BR-87300970 Campo Mourao, Brazil.
   [Munhos Hermoso, Danielle Aparecida; Campos Shimada, Lilian Brites; Gilglioni, Eduardo Hideo; Constantin, Jorgete; Mito, Marcio Shigueaki; Munhos Hermoso, Aparecida Pinto; Ishii Iwamoto, Emy Luiza] Univ Maringa, Lab Expt Steatosis, Dept Biochem, BR-87020900 Maringa, Parana, Brazil.
RP Iwamoto, ELI (corresponding author), Univ Maringa, Lab Biol Oxidat, Dept Biochem, BR-87020900 Maringa, Parana, Brazil.
EM eliiwamoto@uem.br
RI Campos-Shimada, Lilian/M-8719-2013; Gilglioni, Eduardo/H-2784-2012;
   Mito, Masaki/MHY-3297-2025; Ishii-Iwamoto, Emy/C-1323-2013; Constantin,
   Jorgete/G-5815-2013
OI Constantin, Jorgete/0000-0003-4181-6180; Gilglioni, Eduardo
   Hideo/0000-0001-5137-4051; Campos-Shimada, Lilian
   Brites/0000-0002-5226-6519
FU Coordenacao de Aperfeicoamento de Pessoal do Ensino Superior (CAPES)
   [1832/2010]; Fundacao Araucaria do Estado do Parana [006/2011]; Conselho
   Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
FX This work was supported by grants from the Coordenacao de
   Aperfeicoamento de Pessoal do Ensino Superior (CAPES) (1832/2010) and
   Fundacao Araucaria do Estado do Parana (006/2011). Danielle Aparecida
   Munhos Hermoso holds fellowships from the Conselho Nacional de
   Desenvolvimento Cientifico e Tecnologico (CNPq).
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NR 66
TC 20
Z9 22
U1 0
U2 15
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0024-3205
EI 1879-0631
J9 LIFE SCI
JI Life Sci.
PD JUL 15
PY 2016
VL 157
BP 178
EP 186
DI 10.1016/j.lfs.2016.05.044
PG 9
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA DW3CS
UT WOS:000383520300025
PM 27262788
OA hybrid
DA 2025-06-11
ER

PT J
AU Kawai, H
   Deguchi, S
   Deguchi, K
   Yamashita, T
   Ohta, Y
   Shang, JW
   Tian, FF
   Zhang, XM
   Liu, N
   Liu, WT
   Ikeda, Y
   Matsuura, T
   Abe, K
AF Kawai, Hiromi
   Deguchi, Shoko
   Deguchi, Kentaro
   Yamashita, Toru
   Ohta, Yasuyuki
   Shang, Jingwei
   Tian, Fengfeng
   Zhang, Xuemei
   Liu, Ning
   Liu, Wentao
   Ikeda, Yoshio
   Matsuura, Tohru
   Abe, Koji
TI Synergistic benefit of combined amlodipine plus atorvastatin on neuronal
   damage after stroke in Zucker metabolic rat
SO BRAIN RESEARCH
LA English
DT Article
DE Cerebral infarction; Amlodipine; Atorvastatin; Oxidative stress;
   Inflammatory; Zucker rat
ID SPONTANEOUSLY HYPERTENSIVE-RATS; CALCIUM-CHANNEL BLOCKERS; FOCAL
   CEREBRAL-ISCHEMIA; OXIDATIVE STRESS; UP-REGULATION; THERAPY; OBESITY;
   INJURY; BRAIN; NEUROPROTECTION
AB Stroke is a major neurologic disorder and a leading cause of death in the world. We compared neuroprotective effects of single or combination therapy of amlodipine (AM) and atorvastatin (AT) in such a metabolic syndrome model Zucker rat after 90 min of transient middle cerebral artery occlusion (tMCAO). The animals were pretreated with vehicle, AM, AT, or the combination of AM plus AT for 28 days, and at 24 h of tMCAO, infarct volume and immunohistochemical analyses were performed. The combination of AM plus AT treatment decreased the infarct volume stronger than each single treatment with AM or AT. The numbers of positive cells of oxidative stress markers such as 8-hydroxy-2'-deoxyguanosin (8-OHdG), 4-hydroxy-2-nonenal (4-HNE), and advanced end glycation products (AGE) and inflammation markers such as tumor necrosis factor alpha (TNF-alpha) and monocyte chemoattractant protein-1 (MCP-1) decreased dramatically in the combination-treated group compared with single AM or AT-treated group. The present study showed that single AM or AT treatment showed neuroprotective effects both with antioxidative and anti-inflammatory mechanisms, but combination therapy of AM plus AT presented a further synergistic benefit in acute ischemic neural damages. (C) 2010 Elsevier BM. All rights reserved.
C1 [Kawai, Hiromi; Deguchi, Shoko; Deguchi, Kentaro; Yamashita, Toru; Ohta, Yasuyuki; Shang, Jingwei; Tian, Fengfeng; Zhang, Xuemei; Liu, Ning; Liu, Wentao; Ikeda, Yoshio; Matsuura, Tohru; Abe, Koji] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Neurol, Okayama 7008558, Japan.
C3 Okayama University
RP Abe, K (corresponding author), Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Neurol, 2-5-1 Shikatacho, Okayama 7008558, Japan.
EM gms421023@s.okayama-u.ac.jp
RI Thumm, Michael/A-8033-2015; Liu, Ning/B-2875-2010
OI Yamashita, Toru/0000-0003-3634-5679
FU Ministry of Education, Science, Culture and Sports of Japan; Research
   Committee of CNS Degenerative Diseases; Ministry of Health, Labour and
   Welfare of Japan;  [21390267]
FX This work was partly supported by Grant-in-Aid for Scientific Research
   (B) 21390267 and the Ministry of Education, Science, Culture and Sports
   of Japan, and by Grants-in-Aid from the Research Committee of CNS
   Degenerative Diseases (Nakano I), and grants (Itoyama Y, Imai T, Sobue
   G) from the Ministry of Health, Labour and Welfare of Japan.
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NR 31
TC 29
Z9 30
U1 0
U2 8
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0006-8993
EI 1872-6240
J9 BRAIN RES
JI Brain Res.
PD JAN 12
PY 2011
VL 1368
BP 317
EP 323
DI 10.1016/j.brainres.2010.10.046
PG 7
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 714ZJ
UT WOS:000286849900034
PM 20971084
DA 2025-06-11
ER

PT J
AU Das, UN
AF Das, Undurti N.
TI Influence of polyunsaturated fatty acids and their metabolites on stem
   cell biology
SO NUTRITION
LA English
DT Review
DE Essential fatty acids; Eicosanoids; Lipoxins; Resolvins; Protectins;
   Maresins; Nitrolipids; Stem cells; Proliferation; Coronary heart
   disease; Stroke; Diabetes mellitus; Hypertension; Cancer; Depression;
   Schizophrenia; Alzheimer's disease; Collagen vascular diseases
ID ENDOTHELIAL GROWTH-FACTOR; CORONARY-HEART-DISEASE; COLONY-STIMULATING
   FACTOR; C-REACTIVE PROTEIN; ARACHIDONIC-ACID; DIABETES-MELLITUS;
   GENE-EXPRESSION; SYNDROME-X; PROLIFERATION; PROSTAGLANDINS
AB Proinflammatory cytokines and essential fatty acids (EFAs) and their metabolites are altered in coronary heart disease, stroke, diabetes mellitus, hypertension, cancer, depression, schizophrenia, Alzheimer's disease, and collagen vascular diseases, indicating that these diseases not only are low-grade systemic inflammatory conditions but also have defects in the metabolism of EFAs. EFAs and their metabolites such as eicosanoids, lipoxins, resolvins, protectins, maresins, and nitrolipids are biologically active molecules that regulate gene expression and enzyme activity, modulate inflammation, the immune response, and gluconeogenesis by direct and indirect pathways, function directly as agonists of a number of G-protein-coupled receptors, and thus regulate several cellular processes. EFAs and their metabolites activate phosphatidylinositol 3-kinase/murine thymoma viral oncogene homolog 1 (Akt) and p44/42 mitogen-activated protein kinases and stimulate gluconeogenesis and cell proliferation by Ca2+, phospholipase C/protein kinase, events that are also necessary for stem cell proliferation. Stem cells are pluripotent and expected to be of benefit in the management of many clinical conditions. Therefore, I propose that the beneficial actions of EFAs and their metabolites seen in coronary heart disease, stroke, diabetes mellitus, hypertension, atherosclerosis, canter, depression, schizophrenia. Alzheimer's disease, and collagen vascular diseases could be ascribed to their ability to enhance the proliferation and differentiation of embryonic stem cells in addition to their capacity to suppress inflammation. (C) 2011 Elsevier Inc. All rights reserved.
C1 [Das, Undurti N.] UND Life Sci, Shaker Hts, OH USA.
   [Das, Undurti N.] Jawaharlal Nehru Technol Univ, Sch Biotechnol, Kakinada, India.
C3 Jawaharlal Nehru Technological University - Kakinada
RP Das, UN (corresponding author), Jawaharlal Nehru Technol Univ, Sch Biotechnol, Kakinada, India.
EM Undurti@hotmal.com
RI Das, Undurti/A-7918-2009
FU School of Biotechnology, Jawaharlal Nehru Technological University,
   Kakinada, India
FX Dr. Das received a Ramalingaswami fellowship of the School of
   Biotechnology, Jawaharlal Nehru Technological University, Kakinada,
   India, during the tenure of this study.
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NR 77
TC 30
Z9 34
U1 0
U2 12
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0899-9007
EI 1873-1244
J9 NUTRITION
JI Nutrition
PD JAN
PY 2011
VL 27
IS 1
BP 21
EP 25
DI 10.1016/j.nut.2010.04.003
PG 5
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 699JM
UT WOS:000285659700003
PM 20570489
DA 2025-06-11
ER

PT J
AU Sant, KE
   Moreau, HM
   Williams, LM
   Jacobs, HM
   Bowsher, AM
   Boisvert, JD
   Smolowitz, RM
   Pantazis, J
   Annunziato, K
   Nguyen, M
   Timme-Laragy, A
AF Sant, Karilyn E.
   Moreau, Hadley M.
   Williams, Larissa M.
   Jacobs, Haydee M.
   Bowsher, Anna M.
   Boisvert, Jason D.
   Smolowitz, Roxanna M.
   Pantazis, Jacob
   Annunziato, Kate
   Nguyen, Malina
   Timme-Laragy, Alicia
TI Embryonic exposures to mono-2-ethylhexyl phthalate induce larval
   steatosis in zebrafish independent of Nrf2a signaling
SO JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE
LA English
DT Article
DE Phthalate; MEHP; Nrf2; embryo; zebrafish; lipid accumulation; steatosis;
   DOHaD
ID FATTY LIVER-DISEASE; PERFLUOROOCTANESULFONIC ACID PFOS; TRANSCRIPTION
   FACTOR; OXIDATIVE STRESS; PANCREATIC ORGANOGENESIS; NUCLEAR FACTOR;
   OBESITY; MEHP; EXPRESSION; IMPACT
AB Mono-2-ethylhexyl phthalate (MEHP) is the primary metabolite of the ubiquitous plasticizer and toxicant, di-2-ethylhexyl phthalate. MEHP exposure has been linked to abnormal development, increased oxidative stress, and metabolic syndrome in vertebrates. Nuclear factor, Erythroid 2 Like 2 (Nrf2), is a transcription factor that regulates gene expression in response to oxidative stress. We investigated the role of Nrf2a in larval steatosis following embryonic exposure to MEHP. Wild-type and nrf2a mutant (m) zebrafish embryos were exposed to 0 or 200 mu g/l MEHP from 6 to either 96 (histology) or 120 hours post fertilization (hpf). At 120 hpf, exposures were ceased and fish were maintained in clean conditions until 15 days post fertilization (dpf). At 15 dpf, fish lengths and lipid content were examined, and the expression of genes involved in the antioxidant response and lipid processing was quantified. At 96 hpf, a subset of animals treated with MEHP had vacuolization in the liver. At 15 dpf, deficient Nrf2a signaling attenuated fish length by 7.7%. MEHP exposure increased hepatic steatosis and increased expression of peroxisome proliferator-activated receptor alpha target fabp1a1. Cumulatively, these data indicate that developmental exposure alone to MEHP may increase risk for hepatic steatosis and that Nrf2a does not play a major role in this phenotype.
C1 [Sant, Karilyn E.] San Diego State Univ, Sch Publ Hlth, Div Environm Hlth, San Diego, CA 92182 USA.
   [Sant, Karilyn E.; Moreau, Hadley M.; Jacobs, Haydee M.; Annunziato, Kate; Nguyen, Malina; Timme-Laragy, Alicia] Univ Massachusetts, Sch Publ Hlth & Hlth Sci, Dept Environm Hlth Sci, Amherst, MA 01003 USA.
   [Moreau, Hadley M.; Williams, Larissa M.; Bowsher, Anna M.; Boisvert, Jason D.; Pantazis, Jacob] Bates Coll, Dept Biol, Lewiston, ME 04240 USA.
   [Smolowitz, Roxanna M.] Roger Williams Univ, Dept Biol, Bristol, RI 02809 USA.
C3 California State University System; San Diego State University;
   University of Massachusetts System; University of Massachusetts Amherst;
   Roger Williams University
RP Sant, KE (corresponding author), San Diego State Univ, Sch Publ Hlth, San Diego, CA 92128 USA.
EM ksant@sdsu.edu
RI Bowsher, Anna/LVS-0546-2024
OI Sant, Karilyn/0000-0001-8565-2072
FU National Institute of General Medical Sciences of the National
   Institutes of Health [P20 GM103423]; National Institute of Environmental
   Health Sciences [R01 ES025748, R01 ES028201, F32 ES028085]; National
   Institute of Environmental Health Sciences [R01ES028201] Funding Source:
   NIH RePORTER
FX This work was funded by an Institutional Development Award from the
   National Institute of General Medical Sciences of the National
   Institutes of Health (P20 GM103423 to Bates College) as well as support
   from the National Institute of Environmental Health Sciences (R01
   ES025748 and R01 ES028201 to AT-L; F32 ES028085 to KES).
CR [Anonymous], 2014, US
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NR 73
TC 12
Z9 14
U1 0
U2 22
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 2040-1744
EI 2040-1752
J9 J DEV ORIG HLTH DIS
JI J. Dev. Orig. Health Dis.
PD FEB
PY 2021
VL 12
IS 1
BP 132
EP 140
DI 10.1017/S2040174420000057
PG 9
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA PR7HR
UT WOS:000607403300014
PM 32063256
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Pinteric, M
   Podgorski, II
   Hadzija, MP
   Bujak, IT
   Dekanic, A
   Bagaric, R
   Farkas, V
   Sobocanec, S
   Balog, T
AF Pinteric, Marija
   Podgorski, Iva I.
   Hadzija, Marijana Popovic
   Tartaro Bujak, Ivana
   Dekanic, Ana
   Bagaric, Robert
   Farkas, Vladimir
   Sobocanec, Sandra
   Balog, Tihomir
TI Role of Sirt3 in Differential Sex-Related Responses to a High-Fat Diet
   in Mice
SO ANTIOXIDANTS
LA English
DT Article
DE sirtuin 3; high fat diet; sex differences; mice; oxidative stress;
   metabolic stress
ID OXIDATIVE STRESS; SKELETAL-MUSCLE; CALORIE RESTRICTION;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; PPAR-GAMMA; LIVER; CAPACITY;
   C57BL/6J; EXCESS
AB Metabolic homeostasis is differently regulated in males and females. Little is known about the mitochondrial Sirtuin 3 (Sirt3) protein in the context of sex-related differences in the development of metabolic dysregulation. To test our hypothesis that the role of Sirt3 in response to a high-fat diet (HFD) is sex-related, we measured metabolic, antioxidative, and mitochondrial parameters in the liver of Sirt3 wild-type (WT) and knockout (KO) mice of both sexes fed with a standard or HFD for ten weeks. We found that the combined effect of Sirt3 and an HFD was evident in more parameters in males (lipid content, glucose uptake, ppar gamma, cyp2e1, cyp4a14, Nrf2, MnSOD activity) than in females (protein damage and mitochondrial respiration), pointing towards a higher reliance of males on the effect of Sirt3 against HFD-induced metabolic dysregulation. The male-specific effects of an HFD also include reduced Sirt3 expression in WT and alleviated lipid accumulation and reduced glucose uptake in KO mice. In females, with a generally higher expression of genes involved in lipid homeostasis, either the HFD or Sirt3 depletion compromised mitochondrial respiration and increased protein oxidative damage. This work presents new insights into sex-related differences in the various physiological parameters with respect to nutritive excess and Sirt3.
C1 [Pinteric, Marija; Podgorski, Iva I.; Hadzija, Marijana Popovic; Dekanic, Ana; Sobocanec, Sandra; Balog, Tihomir] Rudjer Boskovic Inst, Div Mol Med, Zagreb 10000, Croatia.
   [Bagaric, Robert; Farkas, Vladimir] Rudjer Boskovic Inst, Div Expt Phys, Zagreb 10000, Croatia.
   [Tartaro Bujak, Ivana] Rudjer Boskovic Inst, Div Mat Chem, Zagreb 10000, Croatia.
C3 Rudjer Boskovic Institute; Rudjer Boskovic Institute; Rudjer Boskovic
   Institute
RP Sobocanec, S (corresponding author), Rudjer Boskovic Inst, Div Mol Med, Zagreb 10000, Croatia.
EM mpinter@irb.hr; iskrinj@irb.hr; mhadzija@irb.hr; itartaro@irb.hr;
   adekanic@irb.hr; robert.bagaric@irb.hr; vladimir.farkas@irb.hr;
   ssoboc@irb.hr; balog@irb.hr
RI Tartaro Bujak, Ivana/AAF-3528-2019; Tadijan, Ana/AAM-6369-2021; Farkas,
   Vladimir/JCE-6341-2023; Skrinjar, Iva/K-8977-2017; Sobocanec,
   Sandra/AAP-1416-2020; Hadzija, Marijana/AAV-6519-2021
OI Podgorski, Iva/0000-0002-9423-9711; Tadijan, Ana/0000-0002-5487-3611;
   Popovic Hadzija, Marijana/0000-0001-6522-3721; Pinteric,
   Marija/0000-0003-1049-0237; Sobocanec, Sandra/0000-0001-8915-6009;
   Farkas, Vladimir/0000-0003-0216-4706
FU Croatian Science Foundation (HRZZ) [IP-2014-09-4533]
FX This work was supported by the Croatian Science Foundation (HRZZ), Grant
   no. [IP-2014-09-4533] "SuMERA".
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NR 55
TC 10
Z9 11
U1 0
U2 10
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD FEB
PY 2020
VL 9
IS 2
AR 174
DI 10.3390/antiox9020174
PG 19
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA KU7ET
UT WOS:000519877100098
PM 32093284
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU He, JT
   Zhao, X
   Xu, L
   Mao, CY
AF He, Jin-Ting
   Zhao, Xin
   Xu, Lei
   Mao, Cui-Ying
TI Vascular Risk Factors and Alzheimer's Disease: Blood-Brain Barrier
   Disruption, Metabolic Syndromes, and Molecular Links
SO JOURNAL OF ALZHEIMERS DISEASE
LA English
DT Review
DE Alzheimer's disease; amyloid-beta; blood-brain barrier; inflammation;
   ischemia; metabolic syndrome; oxidative stress; p-tau
ID CEREBRAL AMYLOID ANGIOPATHY; PROTEIN-KINASE-C; APOLIPOPROTEIN-E
   GENOTYPE; OXIDATIVE STRESS; BETA-PEPTIDE; MOUSE MODEL; PRECURSOR
   PROTEIN; ISCHEMIC-STROKE; A-BETA; MITOCHONDRIAL DYSFUNCTION
AB Alzheimer's disease (AD) is a neurodegenerative disorder, marked by cortical and hippocampal deposition of amyloid-beta (A beta) plaques and neurofibrillary tangles and cognitive impairment. Studies indicate a prominent link between cerebrovascular abnormalities and the onset and progression of AD, where blood-brain barrier (BBB) dysfunction and metabolic disorders play key risk factors. Pericyte degeneration, endothelial cell damage, astrocyte depolarization, diminished tight junction integrity, and basement membrane disarray trigger BBB damage. Subsequently, the altered expression of low-density lipoprotein receptor-related protein 1 and receptor for advanced glycation end products at the microvascular endothelial cells dysregulate A beta transport across the BBB. White matter lesions and microhemorrhages, dyslipidemia, altered brain insulin signaling, and insulin resistance contribute to tau and A beta pathogenesis, and oxidative stress, mitochondrial damage, inflammation, and hypoperfusion serve as mechanistic links between pathophysiological features of AD and ischemia. Deregulated calcium homeostasis, voltage gated calcium channel functioning, and protein kinase C signaling are also common mechanisms for both AD pathogenesis and cerebrovascular abnormalities. Additionally, APOE polymorphic alleles that characterize impaired cerebrovascular integrity function as primary genetic determinants of AD. Overall, the current review enlightens key vascular risk factors for AD and underscores pathophysiologic relationship between AD and vascular dysfunction.
C1 [He, Jin-Ting; Xu, Lei] Jilin Univ, China Japan Union Hosp, Dept Neurol, 126 Xiantai St, Changchun 130033, Jilin, Peoples R China.
   [Zhao, Xin] First Hosp Jilin Univ, Dept Paediat, Changchun, Jilin, Peoples R China.
   [Mao, Cui-Ying] Jilin Univ, China Japan Union Hosp, Dept Cardiol, 126 Xiantai St, Changchun 130033, Jilin, Peoples R China.
C3 Jilin University; Jilin University; Jilin University
RP Xu, L (corresponding author), Jilin Univ, China Japan Union Hosp, Dept Neurol, 126 Xiantai St, Changchun 130033, Jilin, Peoples R China.; Mao, CY (corresponding author), Jilin Univ, China Japan Union Hosp, Dept Cardiol, 126 Xiantai St, Changchun 130033, Jilin, Peoples R China.
EM xl1974@yahoo.com; maocyyy@yahoo.com
RI Xu, LiFeng/AAS-9065-2021
FU Jilin Provincial Department of Finance funds in China [Sczsy 201512];
   Jilin Provincial Department of Health funds [20152085]; National Natural
   Science Fund Projects [81671159]; Jilin Province Department of
   International Cooperation Projects [20170414014GH]; Youth Program of
   National Natural Science Foundation of China [81902292]
FX This work was supported by the Jilin Provincial Department of Finance
   funds in China (No. Sczsy 201512); Jilin Provincial Department of Health
   funds (No. 20152085); The National Natural Science Fund Projects (No.
   81671159); Jilin Province Department of International Cooperation
   Projects (No. 20170414014GH) and The Youth Program of National Natural
   Science Foundation of China (No. 81902292). The funders did not
   influence the design of the study, collection, analysis and
   interpretation of data or the draft of this manuscript.
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NR 182
TC 51
Z9 54
U1 1
U2 29
PU IOS PRESS
PI AMSTERDAM
PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS
SN 1387-2877
EI 1875-8908
J9 J ALZHEIMERS DIS
JI J. Alzheimers Dis.
PY 2020
VL 73
IS 1
BP 39
EP 58
DI 10.3233/JAD-190764
PG 20
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA KB2EF
UT WOS:000506311500003
PM 31815697
DA 2025-06-11
ER

PT J
AU Carré, JE
   Affourtit, C
AF Carre, Jane E.
   Affourtit, Charles
TI Mitochondrial Activity and Skeletal Muscle Insulin Resistance in Kidney
   Disease
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE bioenergetics; energy metabolism; ATP turnover; oxidative stress;
   insulin signalling; obesity; diabetic nephropathy; uraemic myopathy;
   renal sarcopenia; muscle wasting
ID TYPE-2 DIABETES-MELLITUS; STAGE RENAL-DISEASE; OXIDATIVE STRESS;
   GLOMERULAR PODOCYTE; BARDOXOLONE METHYL; SIGNALING PATHWAYS;
   ENERGY-METABOLISM; DYSFUNCTION; BETA; COMPLICATIONS
AB Insulin resistance is a key feature of the metabolic syndrome, a cluster of medical disorders that together increase the chance of developing type 2 diabetes and cardiovascular disease. In turn, type 2 diabetes may cause complications such as diabetic kidney disease (DKD). Obesity is a major risk factor for developing systemic insulin resistance, and skeletal muscle is the first tissue in susceptible individuals to lose its insulin responsiveness. Interestingly, lean individuals are not immune to insulin resistance either. Non-obese, non-diabetic subjects with chronic kidney disease (CKD), for example, exhibit insulin resistance at the very onset of CKD, even before clinical symptoms of renal failure are clear. This uraemic insulin resistance contributes to the muscle weakness and muscle wasting that many CKD patients face, especially during the later stages of the disease. Bioenergetic failure has been associated with the loss of skeletal muscle insulin sensitivity in obesity and uraemia, as well as in the development of kidney disease and its sarcopenic complications. In this mini review, we evaluate how mitochondrial activity of different renal cell types changes during DKD progression, and discuss the controversial role of oxidative stress and mitochondrial reactive oxygen species in DKD. We also compare the involvement of skeletal muscle mitochondria in uraemic and obesity-related muscle insulin resistance.
C1 [Carre, Jane E.; Affourtit, Charles] Univ Plymouth, Sch Biomed Sci, Plymouth PL6 8BU, Devon, England.
C3 University of Plymouth
RP Affourtit, C (corresponding author), Univ Plymouth, Sch Biomed Sci, Plymouth PL6 8BU, Devon, England.
EM jane.carre@plymouth.ac.uk; charles.affourtit@plymouth.ac.uk
RI Affourtit, Charles/I-3958-2019; Carre, Jane/AAP-4177-2021
OI Affourtit, Charles/0000-0003-1776-9943; Carre, Jane/0000-0002-0699-104X
FU Daphne Jackson Trust - Kidney Research UK; MRC [G1100165] Funding
   Source: UKRI
FX J.E.C. has a Research Fellowship from the Daphne Jackson Trust that is
   funded by Kidney Research UK.
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NR 138
TC 30
Z9 33
U1 1
U2 15
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD JUN 1
PY 2019
VL 20
IS 11
AR 2751
DI 10.3390/ijms20112751
PG 15
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA IE8OX
UT WOS:000472634100145
PM 31195596
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Amaral, AL
   Batista, JP
   Mariano, IM
   Gonçalves, LF
   Tavares, JB
   De Souza, AV
   Caixeta, DC
   Teixeira, RR
   De Oliveira, EP
   Espindola, FS
   Puga, GM
AF Amaral, Ana Luiza
   Batista, Jaqueline Pontes
   Mariano, Igor Moraes
   Goncalves, Ludimila Ferreira
   Tavares, Julia Buiatte
   de Souza, Adriele Vieira
   Caixeta, Douglas C.
   Teixeira, Renata R.
   de Oliveira, Erick P.
   Espindola, Foued S.
   Puga, Guilherme Morais
TI Redox Status of Postmenopausal Women with Single or Multiple
   Cardiometabolic Diseases Has a Similar Response to Mat Pilates Training
SO ANTIOXIDANTS
LA English
DT Article
DE climacteric; exercise; endogenous antioxidants; Pilates training;
   oxidative stress balance
ID OXIDATIVE STRESS; ANTIOXIDANT STATUS; METABOLIC SYNDROME; AEROBIC
   EXERCISE; MARKERS; MULTIMORBIDITY; PREVENTION; IMPROVES; SYSTEM
AB Postmenopausal women have a high prevalence of cardiometabolic diseases and that may associate with higher oxidative stress. Exercise can contribute to the treatment of such diseases, but some modalities, such as Mat Pilates, need to be further studied in terms of their physiological responses. Our aim was to investigate the effects of 12 weeks of Mat Pilates on redox status in postmenopausal women with one or multiple comorbidities of cardiometabolic diseases. Forty-four postmenopausal women were divided into two groups: SINGLE, composed of women with one cardiometabolic disease (n = 20) and MULT, with multimorbidity (n = 24). Mat Pilates training was conducted three times a week for 12 weeks, and each session lasted 50 min. Plasma samples were collected before and after training to analyze the following redox markers: superoxide dismutase, catalase, glutathione peroxidase, total antioxidant capacity due to ferric-reducing antioxidant power (FRAP), reduced glutathione (GSH), uric acid, and carbonyl protein. ANCOVA showed interaction effects in FRAP (p = 0.014). Both groups had reduced levels of catalase (p = 0.240) and GSH (p = 0.309), and increased levels of carbonyl protein (p = 0.053) after intervention. In conclusion, the redox status of postmenopausal women shows no changes mediated by Mat Pilates training between SINGLE and MULT, except for greater reductions of FRAP in SINGLE.
C1 [Amaral, Ana Luiza; Batista, Jaqueline Pontes; Mariano, Igor Moraes; Goncalves, Ludimila Ferreira; Tavares, Julia Buiatte; Puga, Guilherme Morais] Univ Fed Uberlandia, Lab Cardioresp & Metab Physiol, BR-38400678 Uberlandia, MG, Brazil.
   [de Souza, Adriele Vieira; Caixeta, Douglas C.; Teixeira, Renata R.; Espindola, Foued S.] Univ Fed Uberlandia, Inst Biotechnol, Lab Biochem & Mol Biol, BR-38400902 Uberlandia, MG, Brazil.
   [de Oliveira, Erick P.] Fed Univ Uberlandia UFU, Sch Med, Lab Nutr Exercise & Hlth LaNES, BR-38400902 Uberlandia, MG, Brazil.
   [Puga, Guilherme Morais] Univ Fed Uberlandia, Phys Educ Dept, Benjamin Constant St 1286, BR-38400678 Uberlandia, MG, Brazil.
C3 Universidade Federal de Uberlandia; Universidade Federal de Uberlandia;
   Universidade Federal de Uberlandia
RP Puga, GM (corresponding author), Univ Fed Uberlandia, Lab Cardioresp & Metab Physiol, BR-38400678 Uberlandia, MG, Brazil.; Puga, GM (corresponding author), Univ Fed Uberlandia, Phys Educ Dept, Benjamin Constant St 1286, BR-38400678 Uberlandia, MG, Brazil.
EM ana.amaral@ufu.br; jaqueline.batista@imepac.edu.br; igor.mariano@ufu.br;
   ludimila.goncalves@ufu.br; juliabuiatte@ufu.br; adrielevieira@ufu.br;
   douglas.caixeta@ufu.br; renataroland@ufu.br; erickdeoliveira@ufu.br;
   foued@ufu.br; gmpuga@ufu.br
RI Teixeira, Renata/AAE-1421-2019; de Souza, Adriele/F-2330-2018; de
   Oliveira, Erick/D-1138-2011; Moraes Mariano, Igor/AAD-9572-2020;
   Espindola, Foued/C-5324-2013; Puga, Guilherme/F-4854-2019
OI P. de Oliveira, Erick/0000-0001-8989-8344; Moraes Mariano,
   Igor/0000-0002-8691-8669; Caixeta, Douglas Carvalho/0000-0002-2363-6584;
   Espindola, Foued/0000-0002-6937-1411; Puga,
   Guilherme/0000-0002-9093-6640; Buiatte Tavares,
   Julia/0000-0003-0928-0793; Ferreira Goncalves,
   Ludimila/0000-0002-9861-374X
FU Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior-Brasil
   [CAPES] [001]; National Council for Scientific and Technological
   Development-CNPq [404549/2021-7]; National Institute of Science and
   Technology in Theranostics and Nanobiotechnology-INCT-TeraNano (CNPq);
   FAPEMIG [PPM-00503-18]; CNPq; National Institute of Science and
   Technology in Theranostics and Nanobiotechnology-INCT-TeraNano (FAPEMIG)
FX This study was funded by the Coordenacao de Aperfeicoamento de Pessoal
   de Nivel Superior-Brasil [CAPES]-[Finance Code 001]; National Council
   for Scientific and Technological Development-CNPq (404549/2021-7); and
   the National Institute of Science and Technology in Theranostics and
   Nanobiotechnology-INCT-TeraNano (CNPq and FAPEMIG). FSE receives
   financial support from FAPEMIG (PPM-00503-18). EPO and FSE are
   recipients of the CNPq scholarship for research productivity.
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NR 66
TC 3
Z9 3
U1 0
U2 4
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD AUG
PY 2022
VL 11
IS 8
AR 1445
DI 10.3390/antiox11081445
PG 14
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA 4C3SJ
UT WOS:000846377400001
PM 35892647
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Verma, S
   Tiwari, S
   Verma, N
   Verma, D
AF Verma, Shivam
   Tiwari, Sunita
   Verma, Narsingh
   Verma, Dileep
TI Diurnal Variation of Uric Acid and its Correlation with Certain
   Hormones: A Physiological Review
SO JOURNAL OF RESEARCH IN MEDICAL AND DENTAL SCIENCE
LA English
DT Review
DE Circadian rhythm; Uric acid; Diurnal variation; Thyroid hormones;
   Melatonin; Cortisol
ID CORONARY-HEART-DISEASE; METABOLIC SYNDROME; INDEPENDENT PREDICTOR;
   MELATONIN RECEPTORS; GREEK ATORVASTATIN; SUBGROUP ANALYSIS; OXIDATIVE
   STRESS; FAT DISTRIBUTION; BODY-FAT; ANTIOXIDANT
AB Previous studies showed a diurnal rhythm of uric acid. The mean serum uric acid value between 0800-0900 hours was higher than that observed between 1700-1800 hours. Oxidative stress is traditionally characterized as by imbalance among oxidant and antioxidant factors, occurs commonly in Mets. Antioxidant's system including enzymes like superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase and non-enzymatic substrates like ferritin, transferrin, and uric acid controls oxidative stress. Uric acid is an inactive metabolic result of purine catabolism, has been as of late implicated in various long term illness states, including arterial blood pressure, metabolic condition, diabetes, non-alcoholic fatty liver disorders, and chronic renal disorders. Raised uric acid may end up being one of the more significant remediable problematic factors for metabolic and cardiovascular disorders. A negative correlation is found between the levels of endogenous melatonin and UA. A positive correlation is found between the levels of cortisol and UA. Mets are characterized by hyperactivity of the HPA axis, which leads to "functional hypercortisolism.". Uric acid level is linearly correlated with FT3 and FT4, but not with TSH. In conclusion, catabolic hormones have positive correlation with serum uric acid while hormones which decrease basal metabolism have negative correlation with serum uric acid levels.
C1 [Verma, Shivam; Tiwari, Sunita; Verma, Narsingh; Verma, Dileep] King Georges Med Univ, Dept Physiol, Lucknow 226003, Uttar Pradesh, India.
C3 King George's Medical University
RP Verma, N (corresponding author), King Georges Med Univ, Dept Physiol, Lucknow 226003, Uttar Pradesh, India.
EM narsinghverma@gmail.com
RI verma, nipun/GLN-5512-2022
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NR 49
TC 0
Z9 0
U1 0
U2 4
PU AMBER PUBLICATION
PI GUJARAT
PA 402, PARIJAT APT, WALKESHWARI NAGAR, JAMNAGAR, GUJARAT, 361 008, INDIA
SN 2347-2545
EI 2347-2367
J9 J RES MED DENT SCI
JI J. Res. Med. Dent. Sci.
PY 2021
VL 9
IS 8
BP 267
EP 271
PG 5
WC Medicine, Research & Experimental
WE Emerging Sources Citation Index (ESCI)
SC Research & Experimental Medicine
GA UJ9YS
UT WOS:000691633800003
DA 2025-06-11
ER

PT J
AU Tumova, S
   Kerimi, A
   Porter, KE
   Williamson, G
AF Tumova, Sarka
   Kerimi, Asimina
   Porter, Karen E.
   Williamson, Gary
TI Transendothelial glucose transport is not restricted by extracellular
   hyperglycaemia
SO VASCULAR PHARMACOLOGY
LA English
DT Article
DE Endothelial cell; Glucose transport; Shear stress; Hyperglycaemia;
   Diabetes
ID BLOOD-BRAIN-BARRIER; VASCULAR ENDOTHELIAL-CELLS; N-GLYCOSYLATION;
   DIABETIC COMPLICATIONS; OXIDATIVE STRESS; SHEAR-STRESS; GLUT FAMILY;
   EXPRESSION; DYSFUNCTION; METABOLISM
AB Endothelial cells are routinely exposed to elevated glucose concentrations post-prandially in healthy individuals and permanently in patients with metabolic syndrome and diabetes, and so we assessed their sugar transport capabilities in response to high glucose. In human umbilical vein (HUVEC), saphenous vein, microdermal vessels and aorta, GLUT1 (SLC2A1), GLUT3 (SLC2A3), GLUT6 (SLC2A6), and in microdermal vessels also GLUT12 (SLC2A12), were the main glucose transporters as assessed by mRNA, with no fructose transporters nor SGLT1 (SLC5A1). Uptake of C-14-fructose was negligible. GLUT1 and GLUT3 proteins were detected in all cell types and were responsible for similar to 60% glucose uptake in HUVEC, where both GLUT1 and GLUT3, but not GLUT6 siRNA knock-down, reduced the transport. Under shear conditions, GLUT1 protein decreased, GLUT3 increased, and C-14-deoxy-glucose uptake was attenuated. In high glucose, lipid storage was increased, cell numbers were lower, C-14-deoxy-glucose uptake decreased owing to attenuated GLUT3 protein and less surface GLUT1, and trans-endothelial transport of glucose increased due to cell layer permeability changes. We conclude that glucose transport by endothelial cells is relatively resistant to effects of elevated glucose. Cells would continue to supply it to the underlying tissues at a rate proportional to the blood glucose concentration, independent of insulin or fructose. (C) 2016 Elsevier Inc All rights reserved.
C1 [Tumova, Sarka; Kerimi, Asimina; Williamson, Gary] Univ Leeds, Fac Math & Phys Sci, Leeds LS2 9JT, W Yorkshire, England.
   [Porter, Karen E.] Univ Leeds, Leeds Inst Cardiovasc & Metab Med, Multidisciplinary Cardiovasc Res Ctr, Leeds LS2 9JT, W Yorkshire, England.
C3 University of Leeds; University of Leeds
RP Williamson, G (corresponding author), Univ Leeds, Fac Math & Phys Sci, Leeds LS2 9JT, W Yorkshire, England.
EM g.williamson@leeds.ac.uk
RI Tumova, Sarka/AAD-6353-2019; Williamson, Gary/AAE-9665-2019
OI Williamson, Gary/0000-0002-5624-6267; Tumova, Sarka/0000-0003-2044-4998
FU ERC grant POLYTRUE? [322467]; BACCHUS [FP7-KBBE.2012.2.-01, 312090]
FX This work was supported by ERC grant POLYTRUE? (project number 322467)
   and by funding from Seventh Framework Programme BACCHUS
   (FP7-KBBE.2012.2.-01, project number 312090).
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NR 78
TC 25
Z9 25
U1 2
U2 23
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1537-1891
EI 1879-3649
J9 VASC PHARMACOL
JI Vasc. Pharmacol.
PD DEC
PY 2016
VL 87
BP 219
EP 229
DI 10.1016/j.vph.2016.11.001
PG 11
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA EF9EH
UT WOS:000390633000028
PM 27825869
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Panahi, Y
   Khalili, N
   Sahebi, E
   Namazi, S
   Karimian, MS
   Majeed, M
   Sahebkar, A
AF Panahi, Yunes
   Khalili, Nahid
   Sahebi, Ebrahim
   Namazi, Soha
   Karimian, Maryam Saberi
   Majeed, Muhammed
   Sahebkar, Amirhossein
TI Antioxidant effects of curcuminoids in patients with type 2 diabetes
   mellitus: a randomized controlled trial
SO INFLAMMOPHARMACOLOGY
LA English
DT Article
DE Curcumin; Diabetes mellitus; Oxidative stress; Malondialdehyde; Total
   antioxidant capacity; Superoxide dismutase
ID PLACEBO-CONTROLLED TRIAL; CHRONIC PULMONARY COMPLICATIONS; SYSTEMIC
   OXIDATIVE STRESS; FATTY LIVER-DISEASE; QUALITY-OF-LIFE; METABOLIC
   SYNDROME; SULFUR MUSTARD; PIPERINE COMBINATION; CLINICAL-PRACTICE;
   DOUBLE-BLIND
AB Oxidative stress has a key role in the pathogenesis of type II diabetes mellitus (T2DM) and its vascular complications. Antioxidant therapy has been suggested as a potential approach to blunt T2DM development and progression. The aim of this study was to assess the effects of supplementation with curcuminoids, which are natural polyphenolics from turmeric, on oxidative indices in diabetic individuals.
   In this randomized double-blind placebo-controlled trial, 118 subjects with T2DM were randomized to curcuminoids (1000 mg/day co-administered with piperine 10 mg/day) or matching placebo for a period of 8 weeks. Serum total antioxidant capacity, superoxide dismutase (SOD) activities and malondialdehyde (MDA) concentrations were measured at baseline and after the supplementation period.
   Curcuminoids supplementation caused a significant elevation in serum total antioxidant capacity (TAC) (p < 0.001) and SOD activities (p < 0.001), while serum MDA levels were significantly reduced compared with the placebo group (p < 0.001). These results remained statistically significant after adjustment for potential confounders (baseline differences in body mass index and fasting serum insulin).
   The present results support an antioxidant effect of curcuminoids supplementation in patients with T2DM, and call for future studies to assess the impact of these antioxidant effects on the occurrence of diabetic complications and cardiovascular endpoints.
C1 [Panahi, Yunes] Baqiyatallah Univ Med Sci, Chem Injuries Res Ctr, Tehran, Iran.
   [Khalili, Nahid] Baqiyatallah Univ Med Sci, Dept Endocrinol, Tehran, Iran.
   [Sahebi, Ebrahim; Namazi, Soha] Shiraz Univ Med Sci, Sch Pharm, Dept Pharmacotherapy, POB 1583, Shiraz, Iran.
   [Karimian, Maryam Saberi] Mashhad Univ Med Sci, Quaem Hosp, Clin Res Unit, Student Res Comm,Fac Med, Mashhad, Iran.
   [Majeed, Muhammed] Sabinsa Inc, Princeton, NJ USA.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Biotechnol Res Ctr, Mashhad, Iran.
C3 Baqiyatallah University of Medical Sciences (BMSU); Baqiyatallah
   University of Medical Sciences (BMSU); Shiraz University of Medical
   Science; Mashhad University of Medical Sciences; Mashhad University of
   Medical Sciences
RP Sahebkar, A (corresponding author), Mashhad Univ Med Sci, Biotechnol Res Ctr, Mashhad, Iran.
EM sahebkara@mums.ac.ir
RI Sahebkar, Amirhossein/B-5124-2018; Khalili, Nahid/U-1226-2019
OI Panahi, Yunes/0000-0002-2504-8356
FU Clinical Trial Research Center (Tehran, Iran)
FX This study was financially supported by Clinical Trial Research Center
   (Tehran, Iran). The authors gratefully acknowledge Sami Labs LTD
   (Bangalore, India) for providing the drug material used in this trial.
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NR 62
TC 186
Z9 191
U1 1
U2 47
PU SPRINGER BASEL AG
PI BASEL
PA PICASSOPLATZ 4, BASEL, 4052, SWITZERLAND
SN 0925-4692
EI 1568-5608
J9 INFLAMMOPHARMACOLOGY
JI Inflammopharmacology
PD FEB
PY 2017
VL 25
IS 1
BP 25
EP 31
DI 10.1007/s10787-016-0301-4
PG 7
WC Immunology; Pharmacology & Pharmacy; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Pharmacology & Pharmacy; Toxicology
GA EL2DH
UT WOS:000394429800003
PM 27928704
DA 2025-06-11
ER

PT J
AU Cagliyan, CE
   Kirim, S
   Turkmen, S
   Tekin, K
   Balli, M
   Ayman, L
   Akilli, RE
   Yildirim, A
   Cayli, M
AF Cagliyan, Caglar Emre
   Kirim, Sinan
   Turkmen, Serdar
   Tekin, Kamuran
   Balli, Mehmet
   Ayman, Levent
   Akilli, Rabia Eker
   Yildirim, Arafat
   Cayli, Murat
TI Cardiac Diastolic Function Is Impaired at Rest and Worsens With Exercise
   in Otherwise Healthy Individuals With Insulin Resistance
SO INTERNATIONAL HEART JOURNAL
LA English
DT Article
DE Diastolic stress echocardiography; Heart failure; Tissue Doppler
ID METABOLIC SYNDROME; HEART-FAILURE; STRESS ECHOCARDIOGRAPHY;
   AMERICAN-SOCIETY; RECOMMENDATIONS; RESERVE; RISK; DETERMINANTS;
   ASSOCIATION; DYSFUNCTION
AB Insulin resistance (IR) is a pathophysiological condition and is associated with cardiovascular risk factors including heart failure. However, studies demonstrating myocardial abnormalities in the early phases of IR are limited. The aim of this study was to investigate myocardial function in otherwise healthy individuals with IR.
   Individuals with IR who were free of cardiovascular risk factors and healthy controls were included. Stress echocardiography with tissue Doppler imaging (TDI) was performed. Systolic and diastolic TDI waves were compared in both groups.
   A total of 77 individuals (51 with IR and 26 controls) were included in our study. The tissue early flow (e')/atrial contraction (a') ratio at rest was significantly lower in the IR group (P = 0.003). The annular early flow (E)/e' ratio, a predictor of left ventricular filling pressure, was similar in both groups at rest (P = 0.522). After exercise, e'/a' impairment became more prominent in the IR group (P < 0.001); whereas the E/e' ratio was also significantly lower (7.6 +/- 1.8 versus 6.7 +/- 0.9; P = 0.007) in the IR group.
   Myocardial involvement seems to occur in patients with IR, before the appearance of other cardiovascular risk factors. Exercise induced diastolic worsening may be a predictor of reduced compliance and increased ventricular stiffness. More detailed prospective studies are required for more precise results.
C1 [Cagliyan, Caglar Emre; Akilli, Rabia Eker] Cukurova Univ, Fac Med, Dept Cardiol, TR-01330 Adana, Turkey.
   [Kirim, Sinan; Ayman, Levent] Adana Numune Training & Res Hosp, Dept Internal Med, Adana, Turkey.
   [Turkmen, Serdar] Sanko Univ, Dept Cardiol, Gaziantep, Turkey.
   [Tekin, Kamuran; Balli, Mehmet; Yildirim, Arafat; Cayli, Murat] Adana Numune Training & Res Hosp, Dept Cardiol, Adana, Turkey.
C3 Cukurova University; Ankara Numune Training & Research Hospital; Adana
   Numune Training & Research Hospital; Sanko University; Ankara Numune
   Training & Research Hospital; Adana Numune Training & Research Hospital
RP Cagliyan, CE (corresponding author), Cukurova Univ, Fac Med, Dept Cardiol, TR-01330 Adana, Turkey.
EM cemrec76@hotmail.com
RI Türkmen, Serdar/ABF-8271-2021; yıldırım, arafat/AAW-7589-2021; cagliyan,
   caglar/U-3741-2018
OI TURKMEN, SERDAR/0000-0002-4120-4275
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NR 35
TC 4
Z9 4
U1 0
U2 2
PU INT HEART JOURNAL ASSOC
PI TOKYO
PA UNIV TOKYO, GRADUATE SCHOOL MEDICINE, DEPT CARDIOVASCULAR MEDICINE,
   HONGO 7-3-1, BUNKYO-KU, TOKYO, 113-8655, JAPAN
SN 1349-2365
EI 1349-3299
J9 INT HEART J
JI Int. Heart J.
PD MAY
PY 2015
VL 56
IS 3
BP 345
EP 348
PG 4
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA CN6QD
UT WOS:000358558400018
PM 25902882
OA Bronze
DA 2025-06-11
ER

PT J
AU Fernandez de la Cruz, L
   Isomura, K
   Lichtenstein, P
   Rück, C
   Mataix-Cols, D
AF Fernandez de la Cruz, Lorena
   Isomura, Kayoko
   Lichtenstein, Paul
   Ruck, Christian
   Mataix-Cols, David
TI Morbidity and mortality in obsessive-compulsive disorder: A narrative
   review
SO NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
LA English
DT Review
DE Obsessive-compulsive disorder; Morbidity; Somatic health; Autoimmune
   diseases; Metabolic syndrome; Cardiovascular diseases; Dementia; Sleep
   disorders; Respiratory diseases; Gastrointestinal diseases; Migraine;
   Chronic pain; Mortality; Suicide
ID SEROTONIN REUPTAKE INHIBITORS; IRRITABLE-BOWEL-SYNDROME; ANXIETY
   DISORDERS; RHEUMATIC-FEVER; FOLLOW-UP; PSYCHIATRIC-DISORDERS; MIGRAINE
   HEADACHES; MENTAL-DISORDERS; COMMUNITY SAMPLE; SUICIDE ATTEMPTS
AB Current knowledge on the general somatic health of individuals with obsessive-compulsive disorder (OCD) is very limited. Here, we critically review the emerging literature on the topic. Rapidly accumulating evidence indicates an association between OCD and autoimmune diseases, which is not limited to streptococcus-related conditions. Similarly, an association with metabolic and circulatory system diseases has been reported, which is at least partially independent from psychiatric comorbidities and familial confounders. Preliminary results also suggest potential links with dementia, insomnia, respiratory diseases, gastrointestinal diseases, migraine, and chronic pain, but replication is warranted. The risk of death by suicide in OCD is now well established. OCD has also been associated to increased mortality due to natural causes, but more research on specific causes of death is needed. Clarification of the mechanisms behind the observed associations will be critical to inform the rational design of prevention efforts. In the meantime, while OCD symptom reduction remains a priority, clinicians should also focus on monitoring the general health and promoting healthy lifestyles of persons with OCD.
C1 [Fernandez de la Cruz, Lorena; Isomura, Kayoko; Ruck, Christian; Mataix-Cols, David] Karolinska Inst, Ctr Psychiat Res, Dept Clin Neurosci, Stockholm, Sweden.
   [Fernandez de la Cruz, Lorena; Isomura, Kayoko; Ruck, Christian; Mataix-Cols, David] Stockholm Hlth Care Serv, Stockholm, Sweden.
   [Lichtenstein, Paul] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.
C3 Karolinska Institutet; Karolinska Institutet
RP Fernandez de la Cruz, L (corresponding author), Karolinska Inst, Child & Adolescent Psychiat Res Ctr, Dept Clin Neurosci, Gavlegatan 22 Entre B,Floor 8, SE-11330 Stockholm, Sweden.
EM lorena.fernandez.de.la.cruz@ki.se
RI Mataix-Cols, David/G-3843-2010; Rück, Christian/J-4396-2012; de la Cruz,
   Lorena/E-3591-2010
OI Fernandez de la Cruz, Lorena/0000-0002-1571-5485
FU Swedish Research Council for Health, Working Life and Welfare (FORTE),
   Sweden [2019-00438]; Region Stockholm, Sweden [20200139]; Karolinska
   Institutet, Sweden [2020-01361]; Swedish Heart-Lung Foundation
   [20200139] Funding Source: Swedish Heart-Lung Foundation; Forte
   [2019-00438] Funding Source: Forte; Formas [2019-00438] Funding Source:
   Formas
FX This study is supported by grants from the Swedish Research Council for
   Health, Working Life and Welfare (FORTE), Sweden (grant number
   2019-00438), Region Stockholm, Sweden (grant number 20200139), and
   Karolinska Institutet, Sweden (grant number 2020-01361), all awarded to
   Dr Fern ' andez de la Cruz.
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NR 103
TC 18
Z9 20
U1 3
U2 12
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0149-7634
EI 1873-7528
J9 NEUROSCI BIOBEHAV R
JI Neurosci. Biobehav. Rev.
PD MAY
PY 2022
VL 136
AR 104602
DI 10.1016/j.neubiorev.2022.104602
EA MAR 2022
PG 8
WC Behavioral Sciences; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Behavioral Sciences; Neurosciences & Neurology
GA 0Y4SK
UT WOS:000790381200018
PM 35271916
OA hybrid
DA 2025-06-11
ER

PT J
AU Oladele, CA
   Akintayo, CO
   Badejogbin, OC
   Oniyide, AA
   Omoaghe, AO
   Agunbiade, TB
   Olaniyi, KS
AF Oladele, Comfort Abisola
   Akintayo, Christopher Oloruntoba
   Badejogbin, Olabimpe Caroline
   Oniyide, Adesola Adedotun
   Omoaghe, Adams Olalekan
   Agunbiade, Toluwani Bosede
   Olaniyi, Kehinde Samuel
TI Melatonin ameliorates endocrine dysfunction and defective sperm
   integrity associated with high-fat diet-induced obesity in male Wistar
   rats
SO ANDROLOGIA
LA English
DT Article
DE endocrine; lipid; melatonin; obesity; oxidative stress
ID HORMONE-BINDING-GLOBULIN; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   OXIDATIVE STRESS; ANDROGEN LEVELS; INFERTILE MEN; TESTOSTERONE;
   INFLAMMATION; HYPOGONADISM; MECHANISMS
AB Obesity (OBS) has been established as a link to male hypogonadism with consequent infertility. Previous studies have shown that melatonin (MEL) modulates hypothalamic-pituitary-gonadal function. The present study therefore investigated the hypothesis that MEL supplementation would attenuate spermatogenic and steroidogenic dysfunctions associated with obesity induced by high-fat diet (HFD). Twenty-four adult male Wistar rats (n = 6/group) were used: control group received vehicle (normal saline), obese group received 40% high-fat diet and distilled water, MEL-treated group received MEL (4 mg/kg), and OBS + MEL group received MEL and 40% HFD and the treatment lasted for 12 weeks. HFD caused increased body weight, glucose intolerance, plasma triglyceride and low-density lipoprotein cholesterol/ very low-density lipoprotein cholesterol and malondialdehyde, as well as decreased antioxidant capacity, high-density lipoprotein cholesterol, gonadotrophin-releasing hormone, follicle-stimulating hormone and testosterone and altered sperm parameters. However, all these alterations were attenuated when supplemented with MEL. Taken together, these results indicate that HFD exposure causes endocrine dysfunction and disrupted sperm parameters in obese animals, which are accompanied by lipid peroxidation/defective antioxidant capacity. In addition, the present results suggest that melatonin supplementation restores endocrine function and sperm integrity in obese rat model by suppression of oxidative stress-dependent mechanism.
C1 [Oladele, Comfort Abisola; Akintayo, Christopher Oloruntoba; Badejogbin, Olabimpe Caroline; Oniyide, Adesola Adedotun; Omoaghe, Adams Olalekan; Olaniyi, Kehinde Samuel] Afe Babalola Univ, Coll Med & Hlth Sci, Dept Physiol, PMB 5454, Ado Ekiti 360101, Nigeria.
   [Agunbiade, Toluwani Bosede] Afe Babalola Univ, Coll Med & Hlth Sci, Dept Med Microbiol & Parasitol, Ado Ekiti, Nigeria.
RP Olaniyi, KS (corresponding author), Afe Babalola Univ, Coll Med & Hlth Sci, Dept Physiol, PMB 5454, Ado Ekiti 360101, Nigeria.
EM olaniyisk@abuad.edu.ng
RI Olaniyi, Kehinde/GPK-5850-2022
OI Olaniyi, Kehinde/0000-0002-8229-9688
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NR 80
TC 15
Z9 17
U1 0
U2 10
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0303-4569
EI 1439-0272
J9 ANDROLOGIA
JI Andrologia
PD FEB
PY 2022
VL 54
IS 1
AR e14242
DI 10.1111/and.14242
EA SEP 2021
PG 10
WC Andrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA YD5JI
UT WOS:000693099900001
PM 34490912
OA gold
DA 2025-06-11
ER

PT J
AU Cao, K
   Lv, WQ
   Liu, XY
   Fan, YY
   Wang, KX
   Feng, ZH
   Liu, JS
   Zang, WJ
   Xing, LX
   Liu, JK
AF Cao, Ke
   Lv, Weiqiang
   Liu, Xuyun
   Fan, Yingying
   Wang, Kexin
   Feng, Zhihui
   Liu, Jianshu
   Zang, Weijin
   Xing, Lianxi
   Liu, Jiankang
TI Herba houttuyniae Extract Benefits Hyperlipidemic Mice via
   Activation of the AMPK/PGC-1α/Nrf2 Cascade
SO NUTRIENTS
LA English
DT Article
DE Herba houttuyniae; hyperlipidemia; AMP-activated protein kinase;
   mitochondrial biogenesis; oxidative stress
ID FATTY LIVER-DISEASE; PROTEIN-KINASE; METABOLIC SYNDROME;
   DIABETES-MELLITUS; OXIDATIVE STRESS; AERIAL PARTS; AMPK; DYSFUNCTION;
   HEART; SERUM
AB Hyperlipidemia is associated with metabolic disorders, but the detailed mechanisms and related interventions remain largely unclear. As a functional food in Asian diets, Herba houttuyniae has been reported to have beneficial effects on health. The present research was to investigate the protective effects of Herba houttuyniae aqueous extract (HAE) on hyperlipidemia-induced liver and heart impairments and its potential mechanisms. Male C57BL/6J mice were administered with 200 or 400 mg/kg/day HAE for 9 days, followed by intraperitoneal injection with 0.5 g/kg poloxamer 407 to induce acute hyperlipidemia. HAE treatment significantly attenuated excessive serum lipids and tissue damage markers, prevented hepatic lipid deposition, improved cardiac remodeling, and ameliorated hepatic and cardiac oxidative stress induced by hyperlipidemia. More importantly, NF-E2 related factor (Nrf2)-mediated antioxidant and peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1 alpha)-mediated mitochondrial biogenesis pathways as well as mitochondrial complex activities were downregulated in the hyperlipidemic mouse livers and hearts, which may be attributable to the loss of adenosine monophosphate (AMP)-activated protein kinase (AMPK) activity: all of these changes were reversed by HAE supplementation. Our findings link the AMPK/PGC-1 alpha/Nrf2 cascade to hyperlipidemia-induced liver and heart impairments and demonstrate the protective effect of HAE as an AMPK activator in the prevention of hyperlipidemia-related diseases.
C1 [Cao, Ke; Lv, Weiqiang; Liu, Xuyun; Fan, Yingying; Wang, Kexin; Feng, Zhihui; Liu, Jiankang] Xi An Jiao Tong Univ, Sch Life Sci & Technol, Ctr Mitochondrial Biol & Med, Key Lab Biomed Informat Engn,Minist Educ, Xian 710049, Shaanxi, Peoples R China.
   [Feng, Zhihui; Liu, Jiankang] Xi An Jiao Tong Univ, Frontier Inst Sci & Technol, Xian 710049, Shaanxi, Peoples R China.
   [Liu, Jianshu; Xing, Lianxi] Shaanxi Translat Ctr Funct Foods, Xian 710065, Shaanxi, Peoples R China.
   [Zang, Weijin] Xi An Jiao Tong Univ, Hlth Sci Ctr, Dept Pharmacol, Xian 710061, Shaanxi, Peoples R China.
C3 Ministry of Education - China; Xi'an Jiaotong University; Xi'an Jiaotong
   University; Xi'an Jiaotong University
RP Liu, JK (corresponding author), Xi An Jiao Tong Univ, Sch Life Sci & Technol, Ctr Mitochondrial Biol & Med, Key Lab Biomed Informat Engn,Minist Educ, Xian 710049, Shaanxi, Peoples R China.; Liu, JK (corresponding author), Xi An Jiao Tong Univ, Frontier Inst Sci & Technol, Xian 710049, Shaanxi, Peoples R China.
EM caoke@stu.xjtu.edu.cn; wqlv_xjtu@163.com; liuxuyun2015@126.com;
   peacock5@163.com; KexinWangxjtu@126.com; zhfeng@mail.xjtu.edu.cn;
   JianshuLiu111@126.com; zwj@mail.xjtu.edu.cn; lxxing@nwu.edu.cn;
   j.liu@mail.xjtu.edu.cn
RI Xing, Lianxi/JBJ-0000-2023; Feng, Zhihui/E-7408-2011
FU National Basic Research Program [2015CB553602, 2014CB548200]; National
   Natural Science Foundation of China [31701025, 81571050, 31770917,
   31570777, 91649106]; China Postdoctoral Science Foundation
   [2017M613108]; Fundamental Research Funds for the Central Universities
   [Z201806073, xjj2018081]
FX This research was funded by the National Basic Research Program
   (2015CB553602 to J.L.; 2014CB548200 to Z.F.), the National Natural
   Science Foundation of China (31701025 to K.C.; 81571050 to Z.F.;
   31770917, 31570777, 91649106 to J.L.), the General Financial Grant from
   the China Postdoctoral Science Foundation (2017M613108 to K.C.), and the
   Fundamental Research Funds for the Central Universities (Z201806073,
   xjj2018081 to K.C.).
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NR 46
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U1 4
U2 33
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JAN
PY 2020
VL 12
IS 1
AR 164
DI 10.3390/nu12010164
PG 14
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA KQ3KN
UT WOS:000516825500164
PM 31936037
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Hosogai, N
   Fukuhara, A
   Oshima, K
   Miyata, Y
   Tanaka, S
   Segawa, K
   Furukawa, S
   Tochino, Y
   Komuro, R
   Matsuda, M
   Shimomura, I
AF Hosogai, Naomi
   Fukuhara, Atsunori
   Oshima, Kazuya
   Miyata, Yugo
   Tanaka, Sachiyo
   Segawa, Katsumori
   Furukawa, Shigetada
   Tochino, Yoshihiro
   Komuro, Ryutaro
   Matsuda, Morihiro
   Shimomura, Iichiro
TI Adipose tissue hypoxia in obesity and its impact on adipocytokine
   dysregulation
SO DIABETES
LA English
DT Article
ID ENDOPLASMIC-RETICULUM STRESS; NECROSIS-FACTOR-ALPHA; INSULIN-RESISTANCE;
   MESSENGER-RNA; BLOOD-FLOW; INDUCIBLE FACTOR-1; BINDING-PROTEIN;
   ADIPONECTIN; EXPRESSION; FAT
AB Obesity is linked to a variety of metabolic disorders, such as insulin resistance and atherosclerosis. Dysregulated production of fat-derived secretory factors, adipocytokines, is partly responsible for obesity-linked metabolic disorders. However, the mechanistic role of obesity per se to adipocytokine dysregulation has not been fully elucidated. Here, we show that adipose tissue of obese mice is hypoxic and that local adipose tissue hypoxia dysregulates the production of adipocytokines. Tissue hypoxia was confirmed by an exogenous marker, pimonidazole, and by an elevated concentration of lactate, an endogenous marker. Moreover, local tissue hypoperfusion (measured by colored microspheres) was confirmed in adipose tissue of obese mice. Adiponectin mRNA expression was decreased, and mRNA of C/EBP homologous protein (CHOP), an endoplasmic reticulum (ER) stress-mediated protein, was significantly increased in adipose tissue of obese mice. In 3T3-L1 adipocytes, hypoxia dysregulated the expression of adipocytokines, such as adiponectin and plasminogen activator inhibitor type-1, and increased the mRNAs of ER stress marker genes, CHOP and GRP78 (glucose-regulated protein, 78 kD). Expression of CHOP attenuated adiponectin promoter activity, and RNA interference of CHOP partly reversed hypoxia-induced suppression of adiponectin mRNA expression in adipocytes. Hypoxia also increased instability of adiponectin mRNA. Our results suggest that hypoperfusion and hypoxia in adipose tissues underlie the dysregulated production of adipocytokines and metabolic syndrome in obesity.
C1 Osaka Univ, Grad Sch Med, Dept Metab Med, Suita, Osaka 5650871, Japan.
C3 The University of Osaka
RP Fukuhara, A (corresponding author), Osaka Univ, Grad Sch Med, Dept Metab Med, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan.
EM afukuhara-circ@umin.ac.jp; ichi@imed2.med.osaka-u.ac.jp
RI OSHIMA, KAZUYA/AAO-2097-2021; Fukuhara, Atsunori/A-9601-2018
OI Fukuhara, Atsunori/0000-0002-6289-3778; Miyata,
   Yugo/0000-0002-3245-4600; Oshima, Kazuya/0000-0002-4618-9326
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NR 52
TC 977
Z9 1121
U1 1
U2 52
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0012-1797
EI 1939-327X
J9 DIABETES
JI Diabetes
PD APR
PY 2007
VL 56
IS 4
BP 901
EP 911
DI 10.2337/db06-0911
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 157CW
UT WOS:000245697200001
PM 17395738
OA Bronze
DA 2025-06-11
ER

PT J
AU Pourmontaseri, H
   Bazmi, S
   Sepehrinia, M
   Mostafavi, A
   Arefnezhad, R
   Homayounfar, R
   Vahid, F
AF Pourmontaseri, Hossein
   Bazmi, Sina
   Sepehrinia, Matin
   Mostafavi, Ayda
   Arefnezhad, Reza
   Homayounfar, Reza
   Vahid, Farhad
TI Exploring the application of dietary antioxidant index for disease risk
   assessment: a comprehensive review
SO FRONTIERS IN NUTRITION
LA English
DT Review
DE metabolic disease; mental disorders; cardiovascular diseases; cancer;
   osteoporosis; infertility; obesity
ID NUTRITION EXAMINATION SURVEY; OBSTRUCTIVE PULMONARY-DISEASE;
   HUMAN-PAPILLOMAVIRUS INFECTION; SQUAMOUS-CELL CARCINOMA; 3RD
   NATIONAL-HEALTH; OXIDATIVE STRESS; CARDIOVASCULAR-DISEASE;
   HELICOBACTER-PYLORI; METABOLIC SYNDROME; CANCER RISK
AB Oxidative stress contributes to the development of cardiometabolic diseases and cancers. Numerous studies have highlighted the adverse effects of high reactive oxygen species (ROS) levels in the progression of chronic noncommunicable diseases and also during infections. On the other hand, antioxidants play a crucial role in preventing oxidative stress or postponing cell damage via the direct scavenging of free radicals or indirectly via the Keap1/Nrf2/ARE pathway, among others. Dietary antioxidants can be obtained from various sources, mainly through a plant-based diet, including fruits and vegetables. The dietary antioxidant index (DAI) has been developed to assess total antioxidant intake from diet. This review delineated the performance of DAI in the risk assessment of different diseases. It is suggested that a high DAI score prevents obesity-related diseases, including diabetes mellitus, hyperuricemia, dyslipidemia, and metabolic (dysfunction)-associated steatotic liver disease (MASLD). Additionally, DAI is negatively associated with Helicobacter pylori and Human papillomavirus infection, thus reducing the risk of gastric and cervical cancer. Also, a high intake of antioxidants prevents the development of osteoporosis, miscarriage, infertility, and mental illnesses. However, further prospective observations and clinical trials are warranted to confirm the application of DAI in preventing diseases that have been studied.
C1 [Pourmontaseri, Hossein; Bazmi, Sina; Sepehrinia, Matin] Fasa Univ Med Sci, Student Res Comm, Fasa, Iran.
   [Sepehrinia, Matin] Fasa Univ Med Sci, Noncommunicable Dis Res Ctr, Fasa, Iran.
   [Mostafavi, Ayda] Panjab Univ, Dept Psychol, Chandigarh, India.
   [Arefnezhad, Reza] Coenzyme R Res Inst, Tehran, Iran.
   [Arefnezhad, Reza] Shiraz Univ Med Sci, Student Res Comm, Shiraz, Iran.
   [Sepehrinia, Matin; Homayounfar, Reza] Shahid Beheshti Univ Med Sci, Natl Nutr & Food Technol Res Inst, Fac Nutr Sci & Food Technol, WHO Collaborating Ctr, Tehran, Iran.
   [Vahid, Farhad] Luxembourg Inst Hlth, Dept Precis Hlth, Nutr & Hlth Res Grp, Strassen, Luxembourg.
   [Homayounfar, Reza] Shahid Beheshti Univ Med Sci, Res Inst Endocrine Sci, Micronutrient Res Ctr, Tehran, Iran.
C3 Panjab University; Shiraz University of Medical Science; World Health
   Organization; Shahid Beheshti University Medical Sciences; Luxembourg
   Institute of Health; Shahid Beheshti University Medical Sciences
RP Arefnezhad, R (corresponding author), Coenzyme R Res Inst, Tehran, Iran.; Arefnezhad, R (corresponding author), Shiraz Univ Med Sci, Student Res Comm, Shiraz, Iran.; Homayounfar, R (corresponding author), Shahid Beheshti Univ Med Sci, Natl Nutr & Food Technol Res Inst, Fac Nutr Sci & Food Technol, WHO Collaborating Ctr, Tehran, Iran.; Homayounfar, R (corresponding author), Shahid Beheshti Univ Med Sci, Res Inst Endocrine Sci, Micronutrient Res Ctr, Tehran, Iran.
EM Reza.aref1374@gmail.com; r_homayounfar@yahoo.com
RI Vahid, Farhad/L-7547-2018; Arefnezhad, Reza/ABG-7243-2021; Sepehrinia,
   Matin/KQU-1834-2024; Homayounfar, Reza/L-8813-2017
OI Mostafavi, Ayda/0000-0002-2623-0512
FX The author(s) declare that no financial support was received for the
   research, authorship, and/or publication of this article.
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NR 242
TC 0
Z9 0
U1 1
U2 1
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD JAN 16
PY 2025
VL 11
AR 1497364
DI 10.3389/fnut.2024.1497364
PG 19
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA U0V0V
UT WOS:001409063400001
PM 39885868
OA gold
DA 2025-06-11
ER

PT J
AU Gujjala, S
   Bangeppagari, M
   Devarakonda, VLNP
   Bellamkonda, R
   Bhadramraju, R
   Kameswaran, S
   Ramaswamy, R
   Desireddy, S
AF Gujjala, Sudhakara
   Bangeppagari, Manjunatha
   Devarakonda, Venkata Lakshmi Narasimha Prasad
   Bellamkonda, Ramesh
   Bhadramraju, Ramu
   Kameswaran, Srinivasan
   Ramaswamy, Rajendran
   Desireddy, Saralakumari
TI Pleiotropic effects of Salacia reticulata and Simvastatin
   on oxidative stress and insulin resistance in a rat model
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Article
DE Salacia reticulata; High-fat diet; Oxidative stress; Insulin resistance;
   Metabolic syndrome
ID HIMBUTU AQUEOUS EXTRACT; CARALLUMA-FIMBRIATA; LIVER; ACCUMULATION;
   MIXTURE; OBESITY; INJURY
AB Background: The present study investigated the effects of Salacia reticulata and simvastatin on oxidative stress and insulin resistance in Sprague-Dawley (SD) rats. We compared the protective effect of a methanolic extract of Salacia reticulata (SR) with simvastatin (SVS) in rats fed a high-fat diet (HFD). Methods and results: Male Sprague-Dawley rats were divided into the following five different groups: control (C), C+SR, HFD, HFD+SR, and HFD+SVS. High-fat diet fed rats showed hyperglycemia, hyperinsulinemia, hyperleptinemia, dyslipidemia, and hypoadiponectinemia after 90 days. Treatment of high-fat diet fed rats with SR/ SVS significantly (p < 0.05) reduced high-fat diet induced increases in plasma triglycerides, total cholesterol, very-low-density lipoprotein (VLDL), low-density lipoprotein (LDL) and decreased high- density lipoprotein (HDL) accompanied by an increase in lipid peroxidation (LPO) and protein oxidation. In addition, a significant decrease in the activities of antioxidant enzymes and enzymes of the polyol pathway was observed in rats fed high-fat diet. SR was found to be more effective than SVS. Moreover, infiltration of inflammatory cells and fibrosis in the liver of high-fat diet fed rats by SR/SVS were also prevented. Conclusions: The present study confirms that SR/SVS may be a new and promising remedial approach because of its beneficial effects on the pathophysiological processes of obesity and related metabolic disorders.
C1 [Gujjala, Sudhakara; Bhadramraju, Ramu; Desireddy, Saralakumari] Sri Krishnadevaraya Univ, Dept Biochem, Ananthapuram, Andhra Pradesh, India.
   [Bangeppagari, Manjunatha] Sri Devaraj Urs Acad Higher Educ & Res, Dept Cell Biol & Mol Genet, Kolar 563103, Karnataka, India.
   [Devarakonda, Venkata Lakshmi Narasimha Prasad] Sri Devaraj Urs Acad Higher Educ & Res, Kolar 563103, Karnataka, India.
   [Bellamkonda, Ramesh] Vikrama Simhapuri Univ, Dept Food Technol, SPSR Nellore, Andhra Pradesh, India.
   [Kameswaran, Srinivasan] Vikrama Simhapuri Univ Coll, Dept Bot, Nellore, Andhra Pradesh, India.
   [Ramaswamy, Rajendran] Green Chem Herbal Extract & Formulat, Bangalore, India.
C3 Sri Krishnadevaraya University
RP Gujjala, S; Desireddy, S (corresponding author), Sri Krishnadevaraya Univ, Dept Biochem, Ananthapuram, Andhra Pradesh, India.
EM gsudhasku@gmail.com; skumari1@yahoo.co.in
RI Srinivasan, Kameswaran/LTF-6543-2024; Bangeppagari,
   Manjunatha/AGH-9959-2022; Bellamkonda, Ramesh/IXX-0037-2023;
   BHADRAMRAJU, RAMU/JKH-6441-2023
OI Manjunatha, Bangeppagari/0000-0001-8436-2532; Srinivasan, Dr.
   Kameswaran/0000-0001-7802-9506
FU Indian Council of Medical Research (ICMR), Depatment of Health Research,
   Ministry of Helath and Family Welfare, Government of India [3/1/2 (15)
   /Obs./2021-NCD-II]; University Grants Commission, Government of India
   [PDFSS-2013-14-ST-AND-4524]
FX This work was supported by Indian Council of Medical Research (ICMR),
   Depatment of Health Research, Ministry of Helath and Family Welfare,
   Government of India, for Research Associateship (RA) Fellowship' award
   [Letter no. 3/1/2 (15) /Obs./2021-NCD-II] and University Grants
   Commission, Government of India for Postdoctoral Fellowship award
   [PDFSS-2013-14-ST-AND-4524] .
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PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD AUG
PY 2023
VL 164
AR 114960
DI 10.1016/j.biopha.2023.114960
EA JUN 2023
PG 12
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA K3XW0
UT WOS:001015811100001
PM 37290186
OA gold
DA 2025-06-11
ER

PT J
AU López-Acosta, O
   Cristóbal-Garcia, M
   Cardoso-Saldaña, G
   Carvajal-Aguilera, K
   El-Hafidi, M
AF Lopez-Acosta, Ocarol
   Cristobal-Garcia, Magdalena
   Cardoso-Saldana, Guillermo
   Carvajal-Aguilera, Karla
   El-Hafidi, Mohammed
TI Smooth Muscle Cells from a Rat Model of Obesity and Hyperleptinemia Are
   Partially Resistant to Leptin-Induced Reactive Oxygen Species Generation
SO ANTIOXIDANTS
LA English
DT Article
DE leptin; oxidative stress; smooth muscle cell; metabolic syndrome and
   antioxidant defense
ID OXIDATIVE STRESS; CARDIOVASCULAR-DISEASE; FEEDBACK INHIBITION; RECEPTOR;
   PROLIFERATION; VASOCONSTRICTION; ACTIVATION; MECHANISMS; EXPRESSION;
   TISSUE
AB The aim of this study was to evaluate the effect of leptin on reactive oxygen species' (ROS) generation of smooth muscle cells (SMCs) from a rat model of obesity and hyperleptinemia. Obesity and hyperleptinemia were induced in rats by a sucrose-based diet for 24 weeks. ROS generation was detected by using dichloro-dihydrofluorescein (DCF), a fluorescent ROS probe in primary SMCs culture. An increase in plasma leptin and oxidative stress markers was observed in sucrose-fed (SF) rats. At baseline SMCs from SF rats showed a more than twofold increase in fluorescence intensity (FI) compared to that obtained in control (C) cells. When the C cells were treated with 20 ng leptin, the FI increased by about 250%, whereas the leptin-induced FI in the SF cells increased only by 28%. In addition, sucrose feeding increased the levels of p22phox and gp91phox, subunits of Nox as an O-2(center dot-) source in SMCs. Treatment of cells with leptin significantly increased p22phox and gp91phox levels in C cells and did not affect SF cells. Regarding STAT3 phosphorylation and the content of PTP1B and SOCS3 as protein markers of leptin resistance, they were found to be significantly increased in SF cells. These results suggest that SF aortic SMCs are partially resistant to leptin-induced ROS generation.
C1 [Lopez-Acosta, Ocarol; Cristobal-Garcia, Magdalena; El-Hafidi, Mohammed] Inst Nacl Cardiol Ignacio Chavez, Dept Biomed Cardiovasc, Juan Badiano 1,Colonia Secc 16, Tlalpan 14080, Mexico.
   [Cardoso-Saldana, Guillermo] Inst Nacl Cardiol Ignacio Chavez, Dept Endocrinol, Juan Badiano 1,Colonia Secc 16, Tlalpan 14080, Mexico.
   [Carvajal-Aguilera, Karla] Inst Nacl Pediat, Lab Nutr Expt, Insurgentes Sur 3700, Coyoacan 4570, Mexico.
C3 National Institute of Cardiology - Mexico; National Institute of
   Cardiology - Mexico
RP El-Hafidi, M (corresponding author), Inst Nacl Cardiol Ignacio Chavez, Dept Biomed Cardiovasc, Juan Badiano 1,Colonia Secc 16, Tlalpan 14080, Mexico.
EM ola_runi@hotmail.com; magdalena.cristobal@cardiologia.org.mx;
   cargui@cardiologia.org.mx; kcarvajala@pediatria.gob.mx;
   mohammed.elhafidi@cardiologia.org.mx
FU CONACyT [106845]
FX This work was partially supported by grant No 106845 from CONACyT.
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NR 59
TC 1
Z9 1
U1 2
U2 2
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD MAR
PY 2023
VL 12
IS 3
AR 728
DI 10.3390/antiox12030728
PG 15
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA A7SL7
UT WOS:000957080100001
PM 36978976
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Hu, CY
   Keen, HL
   Lu, KT
   Liu, XB
   Wu, J
   Davis, DR
   Ibeawuchi, SRC
   Vogel, S
   Quelle, FW
   Sigmund, CD
AF Hu, Chunyan
   Keen, Henry L.
   Lu, Ko-Ting
   Liu, Xuebo
   Wu, Jing
   Davis, Deborah R.
   Ibeawuchi, Stella-Rita C.
   Vogel, Silke
   Quelle, Frederick W.
   Sigmund, Curt D.
TI Retinol-binding protein 7 is an endothelium-specific PPARγ cofactor
   mediating an antioxidant response through adiponectin
SO JCI INSIGHT
LA English
DT Article
ID ACTIVATED-RECEPTOR-GAMMA; CEREBRAL VASCULAR DYSFUNCTION;
   DOMINANT-NEGATIVE MUTATIONS; CAUSES INSULIN-RESISTANCE; HIGH-FAT DIET;
   NITRIC-OXIDE; METABOLIC SYNDROME; SIGNALING PATHWAY; DIABETIC MICE;
   CELLS
AB Impaired PPAR. activity in endothelial cells causes oxidative stress and endothelial dysfunction which causes a predisposition to hypertension, but the identity of key PPAR gamma target genes that protect the endothelium remain unclear. Retinol-binding protein 7 (RBP7) is a PPAR gamma target gene that is essentially endothelium specific. Whereas RBP7-deficient mice exhibit normal endothelial function at baseline, they exhibit severe endothelial dysfunction in response to cardiovascular stressors, including high-fat diet and subpressor angiotensin II. Endothelial dysfunction was not due to differences in weight gain, impaired glucose homeostasis, or hepatosteatosis, but occurred through an oxidative stress-dependent mechanism which can be rescued by scavengers of superoxide. RNA sequencing revealed that RBP7 was required to mediate induction of a subset of PPAR gamma target genes by rosiglitazone in the endothelium including adiponectin. Adiponectin was selectively induced in the endothelium of control mice by high-fat diet and rosiglitazone, whereas RBP7 deficiency abolished this induction. Adiponectin inhibition caused endothelial dysfunction in control vessels, whereas adiponectin treatment of RBP7-deficient vessels improved endothelium-dependent relaxation and reduced oxidative stress. We conclude that RBP7 is required to mediate the protective effects of PPAR gamma in the endothelium through adiponectin, and RBP7 is an endothelium-specific PPAR gamma target and regulator of PPAR gamma activity.
C1 [Hu, Chunyan; Keen, Henry L.; Lu, Ko-Ting; Liu, Xuebo; Wu, Jing; Davis, Deborah R.; Ibeawuchi, Stella-Rita C.; Quelle, Frederick W.; Sigmund, Curt D.] Univ Iowa, Dept Pharmacol, Iowa City, IA 52242 USA.
   [Sigmund, Curt D.] Univ Iowa, UIHC Ctr Hypertens Res, Roy J & Lucille A Carver Coll Med, Iowa City, IA USA.
   [Vogel, Silke] Duke NUS Med Sch, Singapore, Singapore.
C3 University of Iowa; University of Iowa; National University of Singapore
RP Sigmund, CD (corresponding author), Univ Iowa, Roy J & Lucille A Carver Coll Med, Hypertens Res, Iowa City, IA 52242 USA.; Sigmund, CD (corresponding author), Univ Iowa, Roy J & Lucille A Carver Coll Med, Dept Pharmacol, Iowa City, IA 52242 USA.; Sigmund, CD (corresponding author), Univ Iowa, Roy J & Lucille A Carver Coll Med, UI Ctr Hypertens Res, Iowa City, IA 52242 USA.
EM curt-sigmund@uiowa.edu
RI Sigmund, Curt/W-1611-2019; Stefanadis, Christodoulos/ABH-2232-2020
OI Wu, PhD, Jing (Jason) O./0000-0003-2013-2863; Quelle,
   Frederick/0000-0002-1184-6170; Stefanadis,
   Christodoulos/0000-0001-5974-6454; Sigmund, Curt/0000-0002-1453-0921;
   Vogel, Silke/0000-0002-6895-3567
FU NIH [HL084207, HL125603, HL131689]; American Heart Association
   [15SFRN23480000]; Roy J. Carver Trust; American Heart Association (AHA)
   [15SFRN23480000] Funding Source: American Heart Association (AHA)
FX We thank Brandon S. Davies for providing us with MLECs. This work was
   supported through research grants from the NIH (HL084207, HL125603,
   HL131689), and American Heart Association to CDS (15SFRN23480000). The
   authors gratefully acknowledge the research support of the Roy J. Carver
   Trust.
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NR 54
TC 29
Z9 32
U1 1
U2 7
PU AMER SOC CLINICAL INVESTIGATION INC
PI ANN ARBOR
PA 2015 MANCHESTER RD, ANN ARBOR, MI 48104 USA
SN 2379-3708
J9 JCI INSIGHT
JI JCI Insight
PD MAR
PY 2017
VL 2
IS 6
AR e91738
DI 10.1172/jci.insight.91738
PG 16
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA EP7ZA
UT WOS:000397594500015
PM 28352663
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Muñoz, A
   Costa, M
AF Munoz, Alexandra
   Costa, Max
TI Nutritionally Mediated Oxidative Stress and Inflammation
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Review
ID BLOOD MONONUCLEAR-CELLS; PROINFLAMMATORY GENE-EXPRESSION; SUBCUTANEOUS
   ADIPOSE-TISSUE; SATURATED FATTY-ACIDS; CARDIOVASCULAR-DISEASE;
   MEDITERRANEAN DIET; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   MACRONUTRIENT COMPOSITION; INTERLEUKIN-10 LEVELS
AB There are many sources of nutritionally mediated oxidative stress that trigger inflammatory cascades along short and long time frames. These events are primarily mediated via NF kappa B. On the short-term scale postprandial inflammation is characterized by an increase in circulating levels of IL-6 and TNF-alpha and is mirrored on the long-term by proinflammatory gene expression changes in the adipocytes and peripheral blood mononuclear cells (PBMCs) of obese individuals. Specifically the upregulation of CCL2/MCP-1, CCL3/MIP-1 alpha, CCL4/MIP-1 beta, CXCL2/MIP-2 alpha, and CXCL3/MIP-2 beta is noted because these changes have been observed in both adipocytes and PBMC of obese humans. In comparing numerous human intervention studies it is clear that pro-inflammatory and anti-inflammatory consumption choices mediate gene expression in humans adipocytes and peripheral blood mononuclear cells. Arachidonic acid and saturated fatty acids (SFAs) both demonstrate an ability to increase pro-inflammatory IL-8 along with numerous other inflammatory factors including IL-6, TNF alpha, IL-1 beta, and CXCL1 for arachidonic acid and IGB2 and CTSS for SFA. Antioxidant rich foods including olive oil, fruits, and vegetables all demonstrate an ability to lower levels of IL-6 in PBMCs. Thus, dietary choices play a complex role in the mediation of unavoidable oxidative stress and can serve to exacerbate or dampen the level of inflammation.
C1 [Munoz, Alexandra; Costa, Max] NYU, Sch Med, Nelson Inst Environm Med, Tuxedo Pk, NY 10987 USA.
   [Costa, Max] NYU, Dept Environm Med, Tuxedo Pk, NY 10987 USA.
C3 New York University; New York University
RP Costa, M (corresponding author), NYU, Sch Med, Nelson Inst Environm Med, 57 Old Forge Rd, Tuxedo Pk, NY 10987 USA.
EM max.costa@nyumc.org
OI Munoz, Alexandra/0000-0002-8734-146X
FU National Science Foundation Graduate Research Fellowship [1137475];
   Division Of Graduate Education; Direct For Education and Human Resources
   [1137475] Funding Source: National Science Foundation
FX This paper is based upon work supported by the National Science
   Foundation Graduate Research Fellowship under Grant no. 1137475. The
   authors thank Yana Chervona for editorial assistance.
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NR 88
TC 145
Z9 159
U1 0
U2 3
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PY 2013
VL 2013
AR 610950
DI 10.1155/2013/610950
PG 11
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA 169PK
UT WOS:000320792100001
PM 23844276
OA Green Published, hybrid, Green Submitted
DA 2025-06-11
ER

PT J
AU Bartiromo, M
   Nardolillo, M
   Ferrara, S
   Russo, G
   Del Giudice, EM
   Di Sessa, A
AF Bartiromo, Mario
   Nardolillo, Michele
   Ferrara, Serena
   Russo, Giuseppina
   Del Giudice, Emanuele Miraglia
   Di Sessa, Anna
TI The challenging role of micro-RNAs in non-alcoholic fatty liver disease
   in children with obesity: is it time for a new era?
SO EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY
LA English
DT Review
DE Biomarkers; children; diagnosis; microRNAs; nonalcoholic fatty liver
   disease; obesity; treatment; >
ID NLRP3 INFLAMMASOME; CIRCULATING MIRNA; NONCODING RNAS; STEATOHEPATITIS;
   EPIGENETICS; METABOLISM; BLOOD; SERUM; NAFLD; PATHOGENESIS
AB IntroductionAs the pediatric obesity epidemic, nonalcoholic fatty liver disease (NAFLD) has become the most common chronic liver disease in childhood. Pediatric NAFLD pathophysiology is tangled and still unclear, but insulin resistance (IR), genetics, epigenetics, oxidative stress, and inflammation act as key players. Due to the increased cardiometabolic risk of these patients, several biomarkers have been proposed for early NAFLD identification, but their clinical utility is poor. Recently, hepatic dysregulation of microRNAs (miRNAs) has been linked to metabolic dysfunction, which in turn implied in NAFLD development. Evidence on the intriguing role of miRNAs in NAFLD pathogenesis has emerging especially in at-risk children such as those with obesity. However, pediatric evidence supporting their potential use as early noninvasive NAFLD tools is still limited but promising.Areas coveredWe provided an overview on the emerging role of miRNAs in pediatric NAFLD by addressing some issues regarding their pathophysiological link with the metabolic milieu and their role as reliable NAFLD markers in children with obesity.Expert opinionStrong evidence supports a potential role of miRNAs as early biomarkers of NAFLD in children with obesity. They might represent a valid diagnostic and targeted therapeutic tool due to its close pathogenic link with the metabolic milieu.
C1 [Bartiromo, Mario; Nardolillo, Michele; Ferrara, Serena; Russo, Giuseppina; Del Giudice, Emanuele Miraglia; Di Sessa, Anna] Univ Campania Luigi Vanvitelli, Dept Woman Child & Gen & Specialized Surg, Naples, Italy.
   [Di Sessa, Anna] Univ Campania Luigi Vanvitelli, Dept Woman Child & Gen & Specialized Surg, Via Luigi De Crecchio 2, I-80138 Naples, Italy.
C3 Universita della Campania Vanvitelli; Universita della Campania
   Vanvitelli
RP Di Sessa, A (corresponding author), Univ Campania Luigi Vanvitelli, Dept Woman Child & Gen & Specialized Surg, Via Luigi De Crecchio 2, I-80138 Naples, Italy.
EM anna.disessa@libero.it
RI del Giudice, Emanuele/AAC-2824-2019; DI SESSA, ANNA/K-3831-2018
OI di sessa, anna/0000-0002-5877-3757
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NR 84
TC 1
Z9 1
U1 1
U2 6
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1747-4124
EI 1747-4132
J9 EXPERT REV GASTROENT
JI Expert Rev. Gastroenterol. Hepatol.
PD AUG 3
PY 2023
VL 17
IS 8
BP 817
EP 824
DI 10.1080/17474124.2023.2242245
EA JUL 2023
PG 8
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA Q2CN9
UT WOS:001037233900001
PM 37497846
DA 2025-06-11
ER

PT J
AU Ng, B
   Camacho, A
   Parra, K
   de la Espriella, R
   Rico, V
   Lozano, S
   Troncoso, M
   Castilla-Puentes, RC
   Cook, BL
   Jimenez, DE
AF Ng, Bernardo
   Camacho, Alvaro
   Parra, Katherine
   de la Espriella, Ricardo
   Rico, Victor
   Lozano, Severiano
   Troncoso, Mirna
   Castilla-Puentes, Ruby C.
   Cook, Benjamin L.
   Jimenez, Daniel E.
TI Differences in BMI between Mexican and Colombian patients receiving
   antipsychotics: results from the International Study of Latinos on
   Antipsychotics (ISLA)
SO ETHNICITY & HEALTH
LA English
DT Article
DE Latino; antipsychotics; obesity; cardiometabolic risk
ID GENERALIZED ANXIETY DISORDER; BODY-MASS INDEX; CARDIOVASCULAR RISK; FTO
   GENE; PREVALENCE; OBESITY; AMERICAN; SCHIZOPHRENIA; RELIABILITY;
   OLANZAPINE
AB Objective: The objective of this study is to examine the association of country of residence with body mass index (BMI) between Mexican and Colombian patients exposed to antipsychotics. We hypothesize that there will be a significant association between country of residence and BMI and that Mexican patients will have higher BMI than their Colombian counterparts. Design: The International Study of Latinos on Antipsychotics (ISLA) is a multisite, international, cross sectional study of adult Latino patients exposed to antipsychotics in two Latin American Countries (i.e. Mexico and Colombia). Data were collected from a total of 205 patients (149 from Mexico and 56 from Colombia). The sites in Mexico included outpatient clinics in Mexicali, Monterrey and Tijuana. In Colombia, data were collected from outpatient clinics in Bogota. For this study we included patients attending outpatient psychiatric community clinics that received at least one antipsychotic (new and old generation) for the last 3 months. A linear regression model was used to determine the association of country of residence with BMI for participants exposed to an antipsychotic. Results: After controlling for demographics, behaviors, biological and comorbid psychiatric variables, there was a significant difference between Colombia vs. Mexico in the BMI of patients exposed to antipsychotics (beta = 4.9; p < 0.05). Conclusion: Our hypotheses were supported. These results suggest that differences in BMI in patients exposed to antipsychotics in Mexico and Colombia may reflect differences in prevalence of overweight/obesity at the population level in the respective countries, and highlights the involvement of other risk factors, which may include genetics.
C1 [Ng, Bernardo; Camacho, Alvaro] Univ Calif San Diego, Dept Psychiat, San Diego, CA 92103 USA.
   [Ng, Bernardo] Sun Valley Behav & Res Ctr, Imperial, CA USA.
   [Camacho, Alvaro] Clin la Paz, Bogota, Colombia.
   [Parra, Katherine; de la Espriella, Ricardo] Inst Psiquiatr Estado Baja California, Mexicali, Baja California, Mexico.
   [Rico, Victor; Lozano, Severiano] Unidad Rehabil Psiquiatr, Monterrey, Mexico.
   [Troncoso, Mirna] Hosp Salud Mental Tijuana, Tijuana, Mexico.
   [Castilla-Puentes, Ruby C.] Johnson & Johnson, W Chester, PA USA.
   [Cook, Benjamin L.] Cambridge Hlth Alliance, Hlth Equ Res Lab, Cambridge, MA USA.
   [Jimenez, Daniel E.] Univ Miami, Miller Sch Med, Dept Psychiat, Miami, FL 33136 USA.
C3 University of California System; University of California San Diego;
   Johnson & Johnson; Johnson & Johnson USA; Harvard University; Harvard
   University Medical Affiliates; Cambridge Health Alliance; University of
   Miami
RP Jimenez, DE (corresponding author), Univ Miami, Miller Sch Med, Dept Psychiat, Miami, FL 33136 USA.
EM dej18@miami.edu
RI Cook, Benjamin/AAA-3543-2022
OI Castilla-Puentes, Ruby/0000-0002-0597-6155
FU NIMH NIH HHS [K23 MH098025] Funding Source: Medline
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NR 30
TC 2
Z9 2
U1 0
U2 0
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 1355-7858
EI 1465-3419
J9 ETHNIC HEALTH
JI Ethn. Health
PD MAY 18
PY 2020
VL 25
IS 4
BP 598
EP 605
DI 10.1080/13557858.2018.1439894
PG 8
WC Ethnic Studies; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Ethnic Studies; Public, Environmental & Occupational Health
GA LM9SB
UT WOS:000532586700008
PM 29514516
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Chávez, JFA
   Gallegos, LIF
   Hernández, GSIR
   Mata, KJM
AF Chavez, Juan Francisco Aguirre
   Gallegos, Leticia Irene Franco
   Hernandez, Guadalupe Simanga Ivett Robles
   Mata, Karla Juanita Montes
TI Relationship between physical activity and health-related quality of
   life in people with cardiovascular diseases
SO RETOS-NUEVAS TENDENCIAS EN EDUCACION FISICA DEPORTE Y RECREACION
LA English
DT Article
DE Cardiovascular diseases; health-related quality of life; physical
   activity; CVD prevention
ID METABOLIC SYNDROME; OBESITY; EXERCISE; ANXIETY; MEXICO; RISK
AB Cardiovascular Diseases (CVD) represent a primary challenge in terms of mortality and economic repercussions for health systems in Mexico and internationally. These conditions can cause a significant deterioration in the Health-Related Quality of Life (HRQoL), impacting the individual's functionality and biological, social, and psychological aspects. Faced with this reality, a literature review has been conducted to unravel how physical activity can mitigate cardiovascular risk and strengthen HRQoL in patients with CVD. Using a rigorous search strategy, 60 relevant articles were identified, excluding those that did not meet the defined inclusion criteria. The analysis derived from these works indicated that physical activity is beneficial in preventing and treating CVD, positively impacting various facets of individual well-being. In conclusion, this study highlights the importance of physical activity as a crucial element in improving HRQoL in patients with CVD. Additionally, its determining role as a preventive strategy against said conditions is highlighted, opening a new paradigm in cardiovascular care management. In the context of the constant fight against CVD, physical activity is not only positioned as an ally but as a silent and promising path towards a future of health and a better quality of life.
C1 [Chavez, Juan Francisco Aguirre; Gallegos, Leticia Irene Franco; Hernandez, Guadalupe Simanga Ivett Robles; Mata, Karla Juanita Montes] Univ Autonoma Chihuahua, Chihuahua, Mexico.
C3 Universidad Autonoma de Chihuahua
RP Mata, KJM (corresponding author), Univ Autonoma Chihuahua, Chihuahua, Mexico.
EM kmontes@uach.mx
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NR 68
TC 1
Z9 1
U1 0
U2 0
PU FEDERACION ESPANOLA ASOC DOCENTES EDUCACION FISICA-FEADEF
PI MURCIA
PA C CABO VIDIO 27, SAN JAVIER, MURCIA, 30730, SPAIN
SN 1579-1726
EI 1988-2041
J9 RETOS-NUEV TEND EDUC
JI Retos
PY 2023
IS 50
BP 1035
EP 1043
PG 9
WC Hospitality, Leisure, Sport & Tourism
WE Emerging Sources Citation Index (ESCI)
SC Social Sciences - Other Topics
GA W3HW4
UT WOS:001090582200001
DA 2025-06-11
ER

PT J
AU Mehta, R
   Dedina, L
   O'Brien, PJ
AF Mehta, Rhea
   Dedina, Liana
   O'Brien, Peter J.
TI Rescuing hepatocytes from iron-catalyzed oxidative stress using vitamins
   B1 and B6
SO TOXICOLOGY IN VITRO
LA English
DT Article
DE Cytotoxicity; Hepatocytes; Reactive oxygen species; Lipid peroxidation;
   Free radical; Iron
ID HIGH-DOSE THIAMINE; DNA-DAMAGE; LIPID-PEROXIDATION;
   CHEMICAL-MODIFICATION; IN-VIVO; INHIBITOR PYRIDOXAMINE;
   MITOCHONDRIAL-FUNCTION; ADVANCED GLYCATION; PLASMA-PROTEIN; COMET ASSAY
AB In the following rescue experiments, iron-mediated hepatocyte oxidative stress cytotoxicity was found to be prevented if vitamin B1 or B6 was added 1 h after treatment with iron. The role of iron in catalyzing Fenton-mediated oxidative damage has been implicated in iron overload genetic diseases, carcinogenesis (colon cancer), Alzheimer's disease and complications associated with the metabolic syndrome through the generation of reactive oxygen species (ROS). The objectives of this study were to interpret the cytotoxic mechanisms and intracellular targets of oxidative stress using "accelerated cytotoxicity mechanism screening" techniques (ACMS) and to evaluate the rescue strategies of vitamins B1 and B6. Significant cytoprotection by antioxidants or ROS scavengers indicated that iron-mediated cytotoxicity could be attributed to reactive oxygen species. Of the B6 vitamers, pyridoxal was best at rescuing hepatocytes from iron-catalyzed lipid peroxidation (LPO), protein oxidation, and DNA damage, while pyridoxamine manifested greatest protection against ROS-mediated damage. Thiamin (B1) decreased LPO, mitochondrial and protein damage and DNA oxidation. Together, these results indicate that added B1 and B6 vitamins protect against the multiple targets of iron-catalyzed oxidative damage in hepatocytes. This study provides insight into the search for multi-targeted natural therapies to slow or retard the progression of diseases associated with Fenton-mediated oxidative damage. (C) 2011 Elsevier Ltd. All rights reserved.
C1 [Mehta, Rhea; O'Brien, Peter J.] Univ Toronto, Dept Pharmaceut Sci, Fac Pharm, Toronto, ON M5S 3M2, Canada.
   [Dedina, Liana; O'Brien, Peter J.] Univ Toronto, Dept Pharmacol & Toxicol, Fac Med, Toronto, ON M5S 3M2, Canada.
C3 University of Toronto; University of Toronto
RP O'Brien, PJ (corresponding author), Univ Toronto, Dept Pharmaceut Sci, Fac Pharm, 144 Coll St, Toronto, ON M5S 3M2, Canada.
EM peter.obrien@utoronto.ca
FU Natural Sciences and Engineering Research Council of Canada
FX This research has been funded by a Natural Sciences and Engineering
   Research Council of Canada Discovery grant.
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NR 82
TC 17
Z9 18
U1 1
U2 19
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0887-2333
J9 TOXICOL IN VITRO
JI Toxicol. Vitro
PD AUG
PY 2011
VL 25
IS 5
BP 1114
EP 1122
DI 10.1016/j.tiv.2011.03.015
PG 9
WC Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Toxicology
GA 787HH
UT WOS:000292366700016
PM 21457772
DA 2025-06-11
ER

PT J
AU Miller-Kasprzak, E
   Bogdanski, P
   Pupek-Musialik, D
   Jagodzinski, PP
AF Miller-Kasprzak, Ewa
   Bogdanski, Pawet
   Pupek-Musialik, Danuta
   Jagodzinski, Pawet P.
TI Insulin Resistance and Oxidative Stress Influence Colony-Forming
   Unit-Endothelial Cells Capacity in Obese Patients
SO OBESITY
LA English
DT Article
ID BODY-MASS INDEX; PROGENITOR CELLS; CARDIOVASCULAR-DISEASE; METABOLIC
   SYNDROME; RISK; ASSOCIATION; IMPACT; CHOLESTEROL; OVERWEIGHT; HYPOTHESIS
AB The aim of this study was to investigate the relationship between a sub-population of endothelial progenitor cells (EPC), namely colony-forming unit-endothelial cells (CFU-EC), their colony-forming capacity and variable clinical parameters, including insulin resistance and oxidative stress, in obese individuals. Thirty-eight obese adults (aged 42.5 +/- 12.7), with BMI 32.3 +/- 4.0 and 13 normal-weight controls (aged 48.2 +/- 12.9; BMI 23.2 +/- 2.3) were studied. CFU-EC colony-forming capacity was impaired in the group of obese individuals compared to the normal-weight controls (P = 0.001). The inverse correlation between homeostasis model assessment-insulin resistance (HOMA(IR)) index and CFU-EC number (r = -0.558, P < 0.0001) as well as positive total antioxidant status of plasma (TAS)/CFU-EC relation were noticed during the study. Additionally, correlations between the concentration of triglycerides (TG), high-density lipoproteins (HDLs), and body composition parameters in the obese participants were established. Our results demonstrate that insulin resistance and oxidative stress have a significant impact on the CFU-EC colony formation in obesity. Moreover, in multivariate regression analysis, in both studied groups, the HOMA(IR) index and HDL concentration were independent predictors of the number of CFU-EC. Endothelium dysfunction, which can be present in obesity, may in part be caused by EPC function impairment in this condition.
C1 [Miller-Kasprzak, Ewa; Jagodzinski, Pawet P.] Poznan Univ Med Sci, Dept Biochem & Mol Biol, Poznan, Poland.
   [Bogdanski, Pawet; Pupek-Musialik, Danuta] Poznan Univ Med Sci, Dept Internal Med Metab Disorders & Hypertens, Poznan, Poland.
C3 Poznan University of Medical Sciences; Poznan University of Medical
   Sciences
RP Miller-Kasprzak, E (corresponding author), Poznan Univ Med Sci, Dept Biochem & Mol Biol, Poznan, Poland.
EM emilka@ump.edu.pl
RI Bogdański, Paweł/ABB-2938-2020; Jagodzinski, Pawel/KWV-0637-2024
OI Jagodzinski, Pawel/0000-0002-9046-6802; Bogdanski,
   Pawel/0000-0002-0563-1624
FU Polish Ministry of Science and Higher Education [NN 402 253934]
FX This work was supported by Grant No. NN 402 253934 (2008-2010) from
   Polish Ministry of Science and Higher Education. The authors wish to
   acknowledge Dr Lianeri for her editorial assistance.
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NR 38
TC 11
Z9 13
U1 0
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1930-7381
EI 1930-739X
J9 OBESITY
JI Obesity
PD APR
PY 2011
VL 19
IS 4
BP 736
EP 742
DI 10.1038/oby.2010.169
PG 7
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 741XV
UT WOS:000288901400012
PM 20706205
OA Bronze
DA 2025-06-11
ER

PT J
AU Xu, BE
   Yang, XY
   Zhu, XP
   Liu, QL
   Zhang, YY
   Zhang, M
   Fan, CM
   Ban, XL
   Aikebaier, G
   Bian, H
AF Xu, Bing'er
   Yang, Xinyu
   Zhu, Xiaopeng
   Liu, Qiling
   Zhang, Yuying
   Zhang, Miao
   Fan, Chenmin
   Ban, Xilei
   Aikebaier, Guligeina
   Bian, Hua
TI The relationship between folic acid and nonalcoholic fatty liver disease
SO CLINICAL AND TRANSLATIONAL DISCOVERY
LA English
DT Review
ID IMPROVES INSULIN-RESISTANCE; COLORECTAL-CANCER RISK; SERUM FOLATE
   LEVELS; DNA METHYLATION; OXIDATIVE STRESS; INTESTINAL MICROBIOTA;
   HOMOCYSTEINE LEVELS; TUMOR PROGRESSION; DIETARY-FOLATE; SUPPLEMENTATION
AB In recent years, the incidence of non-alcoholic fatty liver disease (NAFLD) has been increasing, which has become an explosive interest because of the growing impact on world health. NAFLD is the hepatic manifestation of systemic metabolic syndrome (MS), and the umbrella term that comprises a continuum of liver conditions, from nonalcoholic fatty liver (NAFL) to nonalcoholic steatohepatitis (NASH), has a variable course but can lead to cirrhosis and hepatocellular carcinoma (HCC). currently, there is no pharmacological agent that is therapeutically approved for the treatment of this disease. Folic acid (FA) was one of a water-soluble B vitamins, entirely absorbed from the diet. Numbers of clinical studies have confirmed that patients with NAFLD and insulin resistance are often accompanied by abnormal FA. We investigated the potential effects of FA on NAFLD through the metabolic pathways, DNA synthesis and methylation, oxidative stress in liver and intestinal flora. In addition, FA has an effect on HCC or other cancer. Therefore, FA might be a safe and economical potential treatment method for NAFLD.
   1. The beneficial effects of FA on NAFLD might be the DNA methylation regulation of NAFL-related genes.2. FA may reduce inflammation and ER stress in the liver through direct or indirect effects.3. FA may improve NAFLD by enhance the tight junction and reduce intestinal inflammation. image
C1 [Xu, Bing'er; Yang, Xinyu; Zhu, Xiaopeng; Liu, Qiling; Zhang, Yuying; Zhang, Miao; Fan, Chenmin; Ban, Xilei; Aikebaier, Guligeina; Bian, Hua] Fudan Univ, Zhongshan Hosp, Dept Endocrinologist, Shanghai 200032, Peoples R China.
C3 Fudan University
RP Bian, H (corresponding author), Fudan Univ, Zhongshan Hosp, Dept Endocrinologist, Shanghai 200032, Peoples R China.
EM bianhuaer@126.com
RI Xu, Bing‘er/JYO-7708-2024; zhu, xiaopeng/ADI-0151-2022; yang,
   xinyu/AFD-8194-2022
OI Liu, Qiling/0000-0002-9412-5001; Xu, Binger/0000-0001-6071-883X
FU National Natural Science Foundation of China; National Natural Science
   Foundation of China (NCSF)
FX We are funded by a grant from the National Natural Science Foundation of
   China (NCSF). Thanks are due to colleagues, collaborators, all
   researchers and volunteers who participated in the studies mentioned in
   this review.
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NR 153
TC 2
Z9 2
U1 0
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
EI 2768-0622
J9 CLIN TRANSL DISCOV
JI Clin. Transl. Discov.
PD FEB
PY 2024
VL 4
IS 1
AR e274
DI 10.1002/ctd2.274
PG 18
WC Medicine, Research & Experimental
WE Emerging Sources Citation Index (ESCI)
SC Research & Experimental Medicine
GA PR7Z1
UT WOS:001215887700001
OA gold
DA 2025-06-11
ER

PT J
AU Yang, XF
   Jiang, ZY
   Tian, ZM
   Qiu, YQ
   Wang, L
   Gao, KG
   Hu, YJ
   Ma, XY
AF Yang, X. F.
   Jiang, Z. Y.
   Tian, Z. M.
   Qiu, Y. Q.
   Wang, L.
   Gao, K. G.
   Hu, Y. J.
   Ma, X. Y.
TI INFLAMMATION-RELATED OXIDATIVE STRESS IN WHITE ADIPOSE TISSUES OF AN
   INBRED OBESE PIG
SO ANNALS OF ANIMAL SCIENCE
LA English
DT Article
DE obese pig; adipose tissue; oxidative stress; LPS; inflammation
ID METABOLIC SYNDROME; INSULIN-RESISTANCE; EXPRESSION; PATHWAYS; CELLS;
   MICE
AB The uneven development of adipose tissues reflects a differential occurrence of biological events in vivo while the underlying molecular mechanism remains largely unknown. In the present study, the in vivo inflammatory status of an inbred obese porcine model, Lantang pig, was assessed, aiming to provide evidence for obesity biology. Compared with genetically lean pigs (crossbred, Duroc x Landrace x Large White), Lantang pigs exhibited a larger amount of ultra large adipocytes in subcutaneous adipose tissue accompanied with higher expression of macrophage/monocytes markers and pro-inflammatory genes (TLR4, CD14, CD11 beta, MCP1, TNF alpha, IL1 beta and IL6) and lower expression of cellular antioxidant enzymes (SOD1, 2 and 3). Plasma concentrations of LPS and TNF-alpha were also higher in Lantang pigs than in lean pigs. Among adipose tissues of Lantang pigs, the subcutaneous tissue had the most abundant expression of inflammation related genes (TLR4, CD14, TNF alpha and IL6) and the lowest level of cellular antioxidant genes (SOD 1 and 2), while the perirenal adipose tissue had opposite profile. Significant activation of p38 MAPK pathway was indicated by increased phosphorylation of p38 in the subcutaneous adipose tissue of Lantang pigs. Collectively, the bacteria-derived LPS induced inflammation-associated oxidative stress indeed exists in adipose tissues of Lantang pig, and the differential expressions of inflammatory and antioxidant genes, to some extent, account for the uneven development of the adipose tissue within bodies.
C1 [Yang, X. F.; Jiang, Z. Y.; Tian, Z. M.; Qiu, Y. Q.; Wang, L.; Gao, K. G.; Hu, Y. J.; Ma, X. Y.] Guangdong Acad Agr Sci, Lab Anim Nutr & Feed South China, State Key Lab Livestock & Poultry Breeding,Minist, Guangdong Publ Lab Anim Breeding & Nutr,Inst Anim, Guangzhou 510640, Guangdong, Peoples R China.
C3 Guangdong Academy of Agricultural Sciences
RP Jiang, ZY (corresponding author), Guangdong Acad Agr Sci, Lab Anim Nutr & Feed South China, State Key Lab Livestock & Poultry Breeding,Minist, Guangdong Publ Lab Anim Breeding & Nutr,Inst Anim, Guangzhou 510640, Guangdong, Peoples R China.
EM jiangz28@qq.com
RI Yang, Xuefen/GQB-3094-2022
FU National Basic Research Program of China [2013CB127301, 2013CB127304];
   China Agriculture Research System [CARS-36]; Presidential Foundation of
   Guangdong Academy of Agricultural Sciences [201312]
FX Work financed from: National Basic Research Program of China
   (2013CB127301 and 2013CB127304). China Agriculture Research System
   (CARS-36). Presidential Foundation of Guangdong Academy of Agricultural
   Sciences (201312).
CR [Anonymous], 2010, DIABETES
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NR 32
TC 1
Z9 1
U1 0
U2 6
PU WALTER DE GRUYTER GMBH
PI BERLIN
PA GENTHINER STRASSE 13, D-10785 BERLIN, GERMANY
SN 2300-8733
J9 ANN ANIM SCI
JI Ann. Anim. Sci.
PD MAY
PY 2017
VL 17
IS 2
BP 432
EP 444
DI 10.1515/aoas-2016-0054
PG 13
WC Agriculture, Dairy & Animal Science
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture
GA ET7KO
UT WOS:000400475100010
OA gold
DA 2025-06-11
ER

PT J
AU Wu, RN
   Nakatsu, G
   Zhang, X
   Yu, J
AF Wu, Ruonan
   Nakatsu, Geicho
   Zhang, Xiang
   Yu, Jun
TI Pathophysiological mechanisms and therapeutic potentials of macrophages
   in non-alcoholic steatohepatitis
SO EXPERT OPINION ON THERAPEUTIC TARGETS
LA English
DT Review
DE oxidative stress; autophagy; Macrophage; inflammation; lipid metabolism
ID FATTY LIVER-DISEASE; ENDOPLASMIC-RETICULUM STRESS; UNCOUPLING PROTEIN
   UCP2; NECROSIS-FACTOR-ALPHA; KUPFFER CELL; INSULIN-RESISTANCE; HEPATIC
   STEATOSIS; OXIDATIVE STRESS; HEPATOCELLULAR-CARCINOMA; T-CELLS
AB Introduction: Non-alcoholic steatohepatitis (NASH), a hepatic manifestation of metabolic syndrome, is a major cause of morbidity and healthcare burden worldwide. While the molecular pathogenesis of NASH remains unclear and therapeutic options are limited, inflammation is recognized as an essential factor for NASH development. Factors that link NASH to inflammation are macrophages and their secreted cytokines.
   Areas covered: This review summarizes the current knowledge of macrophage-mediated molecular pathways in NASH to shed insights on potential pharmacotherapeutic applications.
   Expert opinion: Macrophages are not only known for their role of phagocytosis in innate immunity, but also for both extrinsic and intrinsic regulation of inflammatory functions of many cytokines. Recent advances have revealed the effects of macrophage recruitment and polarization on the development of NASH. We and others have shown that the proliferation of hepatic macrophages and the subsequent production of pro-inflammatory cytokines initiates inflammatory cascades, orchestrates activities of transcription factors involved in lipid metabolism/translocation, and modulates programmed cell death. Together, these findings support the pathophysiological role of macrophages in the pathogenesis of NASH. Thus, evaluating potential therapeutic targets against the infiltration and/or polarization of specific macrophage subtypes is of clinical interest for alleviation of early-stage NASH, with the goal of halting disease progression.
C1 Chinese Univ Hong Kong, CUHK Shenzhen Res Inst, Li Ka Shing Inst Hlth Sci, Inst Digest Dis, Shatin, Hong Kong, Peoples R China.
   Chinese Univ Hong Kong, CUHK Shenzhen Res Inst, Li Ka Shing Inst Hlth Sci, Dept Med & Therapeut,State Key Lab Digest Dis, Shatin, Hong Kong, Peoples R China.
C3 Chinese University of Hong Kong; CUHK Shenzhen Research Institute;
   Chinese University of Hong Kong; CUHK Shenzhen Research Institute
RP Yu, J (corresponding author), Chinese Univ Hong Kong, Inst Digest Dis, Shatin, Hong Kong, Peoples R China.; Yu, J (corresponding author), Chinese Univ Hong Kong, Dept Med & Therapeut, State Key Lab Digest Dis, Shatin, Hong Kong, Peoples R China.
EM junyu@cuhk.edu.hk
RI Nakatsu, Geicho/MFI-7084-2025; ZHANG, Xiang/N-7918-2015; WU,
   Ruonan/ABB-5759-2022; Jun, Yu/D-8569-2015
OI Nakatsu, Geicho/0000-0001-7239-2750; WU, Ruonan/0000-0001-9466-4462;
   Jun, Yu/0000-0001-5008-2153
FU Collaborative Research Fund of the Research Grant Council Hong Kong
   [CUHK3/CRF/12R, HKU3/CRF11R]; National Basic Research Program of China
   under (973 program) [2013CB531401]; Hong Kong Research Grants Council
   [T12-403-11]; Shenzhen Virtual University Park Support Scheme
FX The authors were supported by the Collaborative Research Fund of the
   Research Grant Council Hong Kong under grant numbers CUHK3/CRF/12R and
   HKU3/CRF11R; the National Basic Research Program of China under (973
   program) under grant number 2013CB531401; the Theme-based Research
   Scheme of the Hong Kong Research Grants Council under grant number
   T12-403-11 and the Shenzhen Virtual University Park Support Scheme
   awarded to the CUHK Shenzhen Research Institute. The authors have no
   other relevant affiliations or financial involvement with any
   organization or entity with a financial interest in or financial
   conflict with the subject matter or materials discussed in the
   manuscript apart from those disclosed.
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NR 99
TC 23
Z9 25
U1 1
U2 28
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1472-8222
EI 1744-7631
J9 EXPERT OPIN THER TAR
JI Expert Opin. Ther. Targets
PD MAY 3
PY 2016
VL 20
IS 5
BP 615
EP 626
DI 10.1517/14728222.2016.1125883
PG 12
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA DI9AV
UT WOS:000373794700001
PM 26609894
DA 2025-06-11
ER

PT J
AU Cotrim, C
   Lopes, LR
   Almeida, AR
   Miranda, R
   Ana, AG
   Cotrim, H
   Andrade, JP
   Picano, E
   Carrageta, M
AF Cotrim, Carlos
   Lopes, Luis R.
   Almeida, Ana R.
   Miranda, Rita
   Ana, Almeida G.
   Cotrim, Hortense
   Andrade, Jose P.
   Picano, Eugenio
   Carrageta, Manuel
TI Efficacy of beta-blocker therapy in symptomatic athletes with
   exercise-induced intra-ventricular gradients
SO CARDIOVASCULAR ULTRASOUND
LA English
DT Article
ID CARDIAC SYNDROME-X; HYPERTROPHIC CARDIOMYOPATHY; CONSENSUS STATEMENT
AB Background: Upright exercise stress echocardiography (SE) induces significant intraventricular gradient (IVG) and systolic anterior motion (SAM) in a large proportion of symptomatic athletes, who may therefore benefit from a negative inotropic therapy.
   The purpose of the present study was to assess the effect of chronic oral b blocker therapy on the occurrence of exercise-induced IVG and mitral valve SAM, in symptomatic athletes.
   Methods: We enrolled 35 symptomatic athletes (age = 23 +/- 11 years) with IVG (> 30 mmHg) during SE off therapy. All repeated SE on chronic oral beta-blocker therapy (atenolol up to 50 mg, bisoprolol up to 10 mg, or metoprolol up to 100 mg daily according to physician-driven choice).
   Results: On therapy, there was during SE a reduction in IVG (35 off vs 17 on beta blocker, p < 0.01), decrease of IVG (102 +/- 34 mmHg off vs 69 +/- 24 mmHg on beta blocker, p < 0.01), peak heart rate (178 +/- 15 bpm off vs 157 +/- 9 bpm on beta blocker), SAM (24 off vs 9 on beta blocker, p < 0.001), symptoms during SE (17 off vs 2 on beta blocker p < 0.001), ST segment depression (13 off vs 2 on beta blocker, p < 0.001).
   Conclusions: In athletes with positive screening on medical evaluation for sports practice and IVG on exertion, treatment with oral beta blockers improved symptoms in the large majority of patients. Symptomatic benefit was mirrored by objective evidence of improvement of echocardiographic signs of obstruction (IVG and SAM) and reduction of ischemia-like electrocardiographic changes.
C1 [Cotrim, Carlos; Lopes, Luis R.; Almeida, Ana R.; Miranda, Rita; Andrade, Jose P.; Carrageta, Manuel] Garcia de Orta Hosp, Dept Cardiol, Almada, Portugal.
   [Ana, Almeida G.] Hosp Santa Maria, Dept Cardiol, Lisbon, Portugal.
   [Cotrim, Carlos; Cotrim, Hortense] Inst Super Saude Egas Moniz, Hlth Sch Egas Moniz, Caparica, Portugal.
   [Picano, Eugenio] CNR, Inst Clin Physiol, I-56100 Pisa, Italy.
   [Cotrim, Carlos; Ana, Almeida G.; Cotrim, Hortense; Carrageta, Manuel] Lisboa Univ Med Sch, Lisbon, Portugal.
C3 Hospital Garcia de Orta; Universidade de Lisboa; Hospital Santa Maria;
   Instituto Superior de Ciencias da Saude Egas Moniz; Consiglio Nazionale
   delle Ricerche (CNR); Istituto di Fisiologia Clinica (IFC-CNR);
   Universidade de Lisboa
RP Cotrim, C (corresponding author), Garcia de Orta Hosp, Dept Cardiol, Almada, Portugal.
EM carlosadcotrim@hotmail.com
RI Cotrim, Carlos/AAI-1691-2021; Cotrim, Hortense/ABE-8255-2020; Picano,
   E/G-2261-2014; Andrade, Jose/J-6689-2012; Almeida, Ana/AAU-2245-2020;
   Lopes, Luis/K-7527-2019; Martins, Rui/K-4635-2013
OI Martins, Rui/0000-0003-1862-7066; Cotrim, Carlos/0000-0002-4802-0831;
   Reis, AlessanRSS/0000-0001-8486-7469; Lopes, Luis/0000-0002-6408-4667;
   Cotrim, Carlos/0000-0002-4282-3473; Almeida, Ana Gomes
   de/0000-0003-0360-4363; Cotrim, Hortense/0000-0002-1474-5092
CR Al-Nasser F, 2002, INT J CARDIOL, V86, P199, DOI 10.1016/S0167-5273(02)00312-1
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NR 14
TC 17
Z9 17
U1 0
U2 7
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1476-7120
J9 CARDIOVASC ULTRASOUN
JI Cardiovasc. Ultrasound
PD SEP 2
PY 2010
VL 8
AR 38
DI 10.1186/1476-7120-8-38
PG 5
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 661LX
UT WOS:000282730900003
PM 20813061
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Bukhari, DA
   Faheem, M
   Arshad, S
   Lone, KP
AF Bukhari, Dilara Abbas
   Faheem, Mehwish
   Arshad, Shamoona
   Lone, Khalid P.
TI Effect of High Dietary Consumption of Locally Available Ghee on Renal
   Function in Mice
SO PAKISTAN JOURNAL OF ZOOLOGY
LA English
DT Article
DE High-fat-diet; Renal effects; Oxidative stress; Lipid peroxidation;
   Antioxidant enzymes
ID HIGH-FAT DIET; CHRONIC KIDNEY-DISEASE; METABOLIC SYNDROME; OXIDATIVE
   STRESS; INSULIN-RESISTANCE; DNA-DAMAGE; OBESITY; HEART; ASSOCIATION;
   POPULATION
AB The study was designed to evaluate the detrimental effects of dietary consumption of Banaspati ghee on renal function of mice. Two locally manufactured brand of Banaspati ghee daily to mice at a rate of 10% of their daily food intake for a period of 4 weeks. After 4 weeks, both male and female mice were sacrificed and kidneys were taken out. Biochemical parameters e.g., lipid peroxidation (LPO), catalase (CAT), glutathione-S-transferase (GST), reduced glutathione (GSH) were determined to evaluate oxidative stress while urea and creatinine, was used to evaluate kidney function. It was found that there was an increase in weight (p<0.05) of both males and female mice fed with diet containing ghee. Kidney LPO and CAT were significantly increased in both male and female mice. GSH level showed decreasing trend in female while increase was observed for male kidney. Creatinine level increased in both male and female experimental groups compared with control. In the light of present results, it was concluded that high daily intake of ghee available in market can cause damage to vital organs like kidney. In general female physiological system seems to be more prone to damage caused by these diets as compared to male physiological system.
C1 [Bukhari, Dilara Abbas; Faheem, Mehwish; Arshad, Shamoona; Lone, Khalid P.] Govt Coll Univ, Dept Zool, Lahore, Pakistan.
C3 Government College University Lahore
RP Bukhari, DA (corresponding author), Govt Coll Univ, Dept Zool, Lahore, Pakistan.
EM dilaraabbas@yahoo.com
RI Faheem, Mehwish/ABG-6649-2020
CR Aguila MB, 2003, NUTRITION, V19, P347, DOI 10.1016/S0899-9007(02)00934-6
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NR 38
TC 1
Z9 1
U1 0
U2 1
PU ZOOLOGICAL SOC PAKISTAN
PI LAHORE
PA UNIV PUNJAB, NEW CAMPUS, C/O DEPT ZOOLOGY, LAHORE, PAKISTAN
SN 0030-9923
J9 PAK J ZOOL
JI Pak. J. Zool.
PD JUN
PY 2020
VL 52
IS 3
BP 901
EP 907
DI 10.17582/journal.pjz/20190623160652
PG 7
WC Zoology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Zoology
GA KX2SQ
UT WOS:000521731600010
OA gold
DA 2025-06-11
ER

PT J
AU Mondal, S
   Mukherjee, S
AF Mondal, S.
   Mukherjee, S.
TI Long-term dietary administration of diethyl phthalate triggers loss of
   insulin sensitivity in two key insulin target tissues of mice
SO HUMAN & EXPERIMENTAL TOXICOLOGY
LA English
DT Article
DE Diethyl phthalate; liver; adipose tissue; insulin resistance; diabetes;
   oxidative stress
ID BISPHENOL-A; SIGNAL-TRANSDUCTION; GLUCOSE-OXIDATION; SKELETAL-MUSCLE;
   IN-VIVO; METABOLITES; RESISTANCE; POPULATION; STRESS; HEALTH
AB Over the past years, a growing body of work has linked numerous pervasive environmental chemicals with a multitude of adverse reproductive, developmental, behavioral, and metabolic changes in humans and animal models. Plasticizers include a wide variety of phthalate esters that are extensively used in a host of personal day care and cosmetic products. Many population-based studies have indicated a close association between diethyl phthalate (DEP) and diabetes albeit the mechanisms remain much unexplored. Presently, we report that long-term dietary administration of DEP to adult male Swiss albino mice at two different concentrations mirroring the recommended tolerable doses, severely impaired insulin signaling in hepatocytes and adipocytes. This was concomitant with sustained oxidative stress from the overactivation of NADPH oxidase 2, a major intracellular source of reactive oxygen species, in both the cell types. The present study provides evidences of the onset of insulin resistance in mice after chronic exposure to DEP in diet even at lower levels. This, in turn, can have serious pathological consequences with ultimate manifestations of type 2 diabetes and metabolic syndrome (MetS). Thus, by disrupting the central metabolic function of liver and adipose tissue, the key insulin target tissues, daily exposure to phthalates in plastics can potentially contribute to the alarming prevalence of MetS in recent times.
C1 [Mondal, S.; Mukherjee, S.] Visva Bharati, Dept Zool, Endocrinol & Metab Lab, Santini Ketan 731235, W Bengal, India.
C3 Visva Bharati University
RP Mukherjee, S (corresponding author), Visva Bharati, Dept Zool, Endocrinol & Metab Lab, Santini Ketan 731235, W Bengal, India.
EM sutapa.mukherjee2010@gmail.com
RI Mondal, Shirsha/AAG-4194-2019; Mukherjee, Sutapa/AAV-1322-2020
OI Mondal, Dr. Shirsha/0000-0003-1732-5883
FU UGC-CAS, Govt. of India [F.5-11/2012 [SAP-II]]; DST-FIST, Govt. of India
   [SR/FST/LS II-031/2013 [C]]; DST-PURSE, Govt. of India
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: the
   authors acknowledge the Head, Department of Zoology (supported by
   UGC-CAS No. F.5-11/2012 [SAP-II], DST-FIST No. SR/FST/LS II-031/2013 [C]
   and DST-PURSE, Govt. of India) Visva-Bharati, Santiniketan for providing
   all infrastructural facilities.
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NR 30
TC 21
Z9 23
U1 2
U2 24
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0960-3271
EI 1477-0903
J9 HUM EXP TOXICOL
JI Hum. Exp. Toxicol.
PD JUL
PY 2020
VL 39
IS 7
BP 984
EP 993
AR 0960327120909526
DI 10.1177/0960327120909526
EA MAR 2020
PG 10
WC Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Toxicology
GA LV2JS
UT WOS:000525276600001
PM 32129097
DA 2025-06-11
ER

PT J
AU Martel, C
   Degli Esposti, D
   Bouchet, A
   Brenner, C
   Lemoine, A
AF Martel, Cecile
   Degli Esposti, Davide
   Bouchet, Antonin
   Brenner, Catherine
   Lemoine, Antoinette
TI Non-Alcoholic Steatohepatitis: New Insights from OMICS Studies
SO CURRENT PHARMACEUTICAL BIOTECHNOLOGY
LA English
DT Review
DE Biomarker; inflammation; liver; mitochondria; NAFLD; omics
ID GENOME-WIDE ASSOCIATION; FATTY LIVER-DISEASE; INSULIN-RESISTANCE;
   HEPATIC LIPOTOXICITY; MOLECULAR-MECHANISMS; BIOMARKER DISCOVERY;
   PROTEOMIC ANALYSIS; LIPIDOMIC ANALYSIS; GENE-EXPRESSION; STEATOSIS
AB Non-alcoholic fatty liver disease (NAFLD) is the most common liver pathology characterized by fat accumulation in a context of metabolic syndrome or insulin resistance. It can be associated with obesity, diabetes, hyperinsulinemia, dyslipidemia as well as hypertension. NAFLD consists of a large spectrum of hepatic lesions including benign steatosis, non-alcoholic steatohepatitis (NASH), cirrhosis or hepatocellular carcinoma. Upon chronic stress, NASH would occur via at least "two-hits" process involving modulation of a high number of genes and proteins. Firstly, the accumulation of fat, either due to the increased inflow of free fatty acids or de novo lipogenesis, leads to steatosis. Secondly, when adaptive mechanisms for stress tolerance are overwhelmed, lipotoxicity and chronic inflammation trigger major hepatic damages, mainly via oxidative and inflammatory stress, lipid peroxidation and cell death. As a consequence, all these processes concur to favor steatohepatitis, fibrosis and cancer. Recently, the elucidation of physiopathological signaling cascades controlling NAFLD and NASH benefited from large-scale studies, namely the omics, such as transcriptomics, genomics, proteomics, and lipidomics. The advent of lipidomics would allow shedding light upon the respective roles of triglyceride and fatty acid metabolites in the lipotoxic liver injury hypothesis for the pathogenesis of NASH. In this review, the contribution of the omics to the understanding of the molecular basis of NASH is discussed that could offer perspectives for novel biomarkers discovery.
C1 [Martel, Cecile; Degli Esposti, Davide; Bouchet, Antonin; Brenner, Catherine; Lemoine, Antoinette] Univ Paris 11, Inserm U1004, Inst Andre Lwoff, PRES Univ Paris,Inst Foie, F-94800 Villejuif, France.
   [Degli Esposti, Davide; Lemoine, Antoinette] Fac Pharm Chatenay Malabry, F-92296 Chatenay Malabry, France.
   [Martel, Cecile; Brenner, Catherine] Univ Paris 11, Fac Pharm, Inserm UMR S 769, F-92296 Chatenay Malabry, France.
   [Lemoine, Antoinette] Hop Paul Brousse, AP HP, Serv Biochim & Biol Mol, F-94804 Villejuif, France.
C3 Universite Paris Saclay; Institut National de la Sante et de la
   Recherche Medicale (Inserm); Universite Paris Saclay; Institut National
   de la Sante et de la Recherche Medicale (Inserm); Universite Paris
   Saclay; Assistance Publique Hopitaux Paris (APHP); Hopital Universitaire
   Paul-Brousse - APHP
RP Brenner, C (corresponding author), Univ Paris 11, Inserm U1004, Inst Andre Lwoff, PRES Univ Paris,Inst Foie, 12-14 Ave Paul Vaillant Couturier, F-94800 Villejuif, France.
EM catherine.brenner-jan@u-psud.fr; antoinette.lemoine@pbr.aphp.fr
RI Degli Esposti, Davide/M-1917-2015; LEMOINE, Antoinette/R-4551-2018;
   degli esposti, davide/D-6352-2018
OI degli esposti, davide/0000-0003-1390-4845
FU le Centre National de la Recherche Scientifique (CNRS); l'Agence
   Nationale de la Recherche (ANR) [ANR-08PCVI-0008-01]; l'Institut
   National pour le Cancer (INCa) [2008-1-PL BIO-04-CNS ON1]; l'Universite
   Paris Sud; NRB-Vaincre le Cancer; Groupement Cooperatif de
   Transplantation de l'Ile de France (GCIF)
FX The work of CB is supported by le Centre National de la Recherche
   Scientifique (CNRS), and l'Agence Nationale de la Recherche (ANR,
   ANR-08PCVI-0008-01). CB is also supported by l'Institut National pour le
   Cancer (INCa, 2008-1-PL BIO-04-CNS ON1) and l'Universite Paris Sud
   (Programme Attractivite). The work of AL and DDE has been supported by
   NRB-Vaincre le Cancer and Groupement Cooperatif de Transplantation de
   l'Ile de France (GCIF).
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NR 66
TC 38
Z9 44
U1 0
U2 43
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1389-2010
EI 1873-4316
J9 CURR PHARM BIOTECHNO
JI Curr. Pharm. Biotechnol.
PD APR
PY 2012
VL 13
IS 5
BP 726
EP 735
DI 10.2174/138920112799857558
PG 10
WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
GA 916PV
UT WOS:000302116600006
PM 22122481
DA 2025-06-11
ER

PT J
AU Gupte, SA
AF Gupte, Sachin A.
TI Glucose-6-phosphate dehydrogenase: A novel therapeutic target in
   cardiovascular diseases
SO CURRENT OPINION IN INVESTIGATIONAL DRUGS
LA English
DT Review
DE 6-aminonicotinamide; dehydroepiandrosterone; diabetes; epiandrosterone;
   heart failure; metabolic syndrome; pulmonary hypertension
ID VASCULAR SMOOTH-MUSCLE; PENTOSE-PHOSPHATE PATHWAY; HYPOXIC
   PULMONARY-HYPERTENSION; OXIDANT STRESS; NITRIC-OXIDE; OXIDATIVE STRESS;
   ISCHEMIA-REPERFUSION; DEFICIENCY DECREASES; CONTRACTILE FUNCTION;
   ENDOTHELIAL-CELLS
AB Vascular dysfunction associated with diabetes, heart failure and pulmonary hypertension is the major cause of morbidity and mortality worldwide. Although the causes of vascular dysfunction remain unclear, altered glucose metabolism appears to be a common factor in these diseases. For example, in diabetes, increased glucose-6-phosphate dehydrogenase (G6PD) activity and elevated NADPH levels are associated with endothelial and vascular dysfunction. Also, there is a 10-fold increase in myocardial G6PD expression and a 2-fold increase in G6PD activity in pacing-induced heart failure compared with normal hearts. In addition, the inhibition of G6PD ameliorates chronic hypoxic pulmonary hypertension. Lastly, G6PD plays a role in mediating angiotensin II-induced hypertrophy of smooth muscle and in the development of atherosclerosis. While it is understood that G6PD-derived NADPH, which is a cofactor for NADPH oxidase, enhances superoxide anion generation and elevates oxidative stress in diabetes, heart failure, and angiotensin II-induced hypertrophy of smooth muscle, there are no specific drugs available to study the role of G6PD and G6PD-derived NADPH in organ function and the development of human diseases. This warrants the development of new drugs or genetic approaches to target G6PD for investigational and clinical use. This review discusses the specificity and side effects of existing investigational G6PD inhibitors.
C1 Univ S Alabama, Coll Med, Dept Biochem & Mol Biol, Mobile, AL 36688 USA.
C3 University of South Alabama
RP Gupte, SA (corresponding author), Univ S Alabama, Coll Med, Dept Biochem & Mol Biol, MSB 2310,307 Univ Blvd N, Mobile, AL 36688 USA.
EM sagupte@usouthal.edu
FU American Heart Association [0435070N]; National Heart, Lung and Blood
   Institute [R01HL085352]; American Heart Association (AHA) [0435070N]
   Funding Source: American Heart Association (AHA)
FX This research was support by the American Heart Association (Grant
   number 0435070N) and the National Heart, Lung and Blood Institute
   (R01HL085352).
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NR 72
TC 57
Z9 64
U1 0
U2 15
PU THOMSON SCIENTIFIC
PI LONDON
PA MIDDLESEX HOUSE, 34-42 CLEVELAND STREET, LONDON, W1T 4JE, ENGLAND
SN 1472-4472
J9 CURR OPIN INVEST DR
JI Curr. Opin. Investig. Drugs
PD SEP
PY 2008
VL 9
IS 9
BP 993
EP 1000
PG 8
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 341EE
UT WOS:000258696200007
PM 18729006
DA 2025-06-11
ER

PT J
AU Ruiz-Ramírez, A
   López-Acosta, O
   Barrios-Maya, M
   El-Hafidi, M
AF Ruiz-Ramirez, A.
   Lopez-Acosta, O.
   Barrios-Maya, M.
   El-Hafidi, M.
TI Uncoupling Protein Overexpression in Metabolic Disease and the Risk of
   Uncontrolled Cell Proliferation and Tumorigenesis
SO CURRENT MOLECULAR MEDICINE
LA English
DT Review
DE Apoptosis; cyt c release; oxidative stress; uncoupling proteins;
   obesity; cancer
ID OXYGEN SPECIES PRODUCTION; ION-TRANSPORT ACTIVITY; PANCREATIC
   BETA-CELLS; FATTY-ACID OXIDATION; INDUCED APOPTOSIS; MITOCHONDRIAL
   DYSFUNCTION; CANCER-CELLS; DOWN-REGULATION; PROTON LEAK; RAT-LIVER
AB In metabolic diseases such as obesity, metabolic syndrome and type II diabetes, the over-expression of uncoupling proteins (UCPs) in a response to increased reactive oxygen species (ROS) generation by mitochondrial respiratory complexes, and to the excess of free fatty acid (FFA) supply from adipose tissue, may protect cells from oxidative stress, lipotoxicity and in turn from death. UCPs by reducing superoxide anion and H2O2 generation trigger several signals to cell for their adaptation to the lipotoxic microenvironment. In mitochondria, a decrease of cytochrome c (cyt c) and proapoptotic protein release promotes cell survival and proliferation. The altered lipid metabolism also affects cardiolipin susceptibility to the peroxidation, a process involved in the dissociation of cyt c from mitochondrial inner membrane and its release, a key step of apoptosis. Therefore, UCPs by attenuating ROS generation and lipotoxicity may down-regulate programmed cell death, a well-known physiological process controlling cell proliferation contributing to uncontrolled cell proliferation and tumorigenesis. In addition, tumor cells over-expressed UCPs, by inhibiting ROS generation acquire resistance to death during pharmacological treatment with oxidative stress drug inducers. Therefore, the aim of this review is to discuss recent findings regarding the role that UCPs play in cell survival by protecting against ROS generation and maintaining bioenergetic metabolism homeostasis to promote cell proliferation.
C1 [Ruiz-Ramirez, A.; Lopez-Acosta, O.; Barrios-Maya, M.; El-Hafidi, M.] Inst Nacl Cardiol Ignacio Chavez, Dept Biomed Cardiovasc, Juan Badiano 1,Colonia Secc 16, Ciudad De Mexico 14080, Mexico.
C3 National Institute of Cardiology - Mexico
RP El-Hafidi, M (corresponding author), Inst Nacl Cardiol Ignacio Chavez, Dept Biomed Cardiovasc, Juan Badiano 1,Colonia Secc 16, Mexico City 14080, DF, Mexico.
EM medelhafidi@yahoo.com
RI El-Hafidi, Mohammed/AAN-4083-2021
FU CONACyT [106845]; Instituto de Ciencia y Tecnologia del Distrito
   Federal, Mexico City (ICyTDF) [PICDS08-67]
FX This work was supported in part by CONACyT: Grant No. 106845 and by
   Instituto de Ciencia y Tecnologia del Distrito Federal, Mexico City
   (ICyTDF): Grant No. PICDS08-67.
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NR 117
TC 6
Z9 6
U1 0
U2 14
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1566-5240
EI 1875-5666
J9 CURR MOL MED
JI Curr. Mol. Med.
PY 2017
VL 17
IS 9
BP 598
EP 607
DI 10.2174/1566524018666180308110822
PG 10
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA GD6NV
UT WOS:000430626600002
PM 29521228
DA 2025-06-11
ER

PT J
AU Maculewicz, E
   Pabin, A
   Kowalczuk, K
   Dziuda, L
   Bialek, A
AF Maculewicz, Ewelina
   Pabin, Agata
   Kowalczuk, Krzysztof
   Dziuda, Lukasz
   Bialek, Agnieszka
TI Endogenous Risk Factors of Cardiovascular Diseases (CVDs) in Military
   Professionals with a Special Emphasis on Military Pilots
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Review
DE atherosclerosis; crew members; diabetes; hyperlipidemia; hypertension;
   military pilots; obesity; oxidative stress; SNPs; soldiers
ID CORONARY-ARTERY-DISEASE; 10-YEAR FOLLOW-UP; OXIDATIVE STRESS; METABOLIC
   SYNDROME; SEX-HORMONES; HEART-DISEASE; GENETIC-BASIS; COCKPIT CREW;
   ATHEROSCLEROSIS; MORTALITY
AB Cardiovascular disease (CVD) risk factors can be categorized as non-modifiable and modifiable. Modifiable risk factors include some exogenous and behavioral factors that can be easily modified, whereas endogenous modifiable risk factors, such as hypertension, hyperlipidemia, diabetes, or obesity may be modified to a limited extend. An increased prevalence of CVDs as well as their risk factors have been observed in military personnel, as specific military-related stressors are highly correlated with acute cardiac disorders. Military pilots are a subpopulation with great CVD risk due to an accumulation of different psychological and physical stressors also considered to be CVD risk factors. This review presents data concerning CVD risk in military professionals, with a special emphasis on military pilots and crew members. We also discuss the usefulness of novel indicators related to oxidative stress, inflammation, or hormonal status as well as genetic factors as markers of CVD risk. For a correct and early estimation of CVD risk in asymptomatic soldiers, especially if no environmental risk factors coexist, the scope of performed tests should be increased with novel biomarkers. An indication of risk group among military professional, especially military pilots, enables the implementation the early preventive activities, which will prolong their state of health and military suitability.
C1 [Maculewicz, Ewelina] Jozef Pilsudski Univ Phys Educ Warsaw, Fac Phys Educ, PL-00968 Warsaw, Poland.
   [Pabin, Agata; Kowalczuk, Krzysztof; Dziuda, Lukasz] Mil Inst Aviat Med, PL-01755 Warsaw, Poland.
   [Bialek, Agnieszka] Inst Anim Genet, Dept Biotechnol & Nutrigen, Postepu 36A Jastrzebiec, PL-05552 Magdalenka, Poland.
   [Bialek, Agnieszka] Biotechnol Polish Acad Sci, Postepu 36A Jastrzebiec, PL-05552 Magdalenka, Poland.
C3 Jozef Pilsudski University Physical Education in Warsaw; Military
   Institute of Aviation Medicine
RP Bialek, A (corresponding author), Inst Anim Genet, Dept Biotechnol & Nutrigen, Postepu 36A Jastrzebiec, PL-05552 Magdalenka, Poland.; Bialek, A (corresponding author), Biotechnol Polish Acad Sci, Postepu 36A Jastrzebiec, PL-05552 Magdalenka, Poland.
EM ewelina.maculewicz@awf.edu.pl; apabin@wiml.waw.pl;
   kkowalczuk@wiml.waw.pl; ldziuda@wiml.waw.pl; a.bialek@igbzpan.pl
RI Maculewicz, Ewelina/G-6593-2019; Dziuda, Lukasz/G-2613-2013; KOWALCZUK,
   Krzysztof/K-7061-2018; Bialek, Agnieszka/M-3363-2018
OI Maculewicz, Ewelina/0000-0002-3122-3085; Dziuda,
   Lukasz/0000-0003-1816-4604; KOWALCZUK, Krzysztof/0000-0001-8347-0232;
   Bialek, Agnieszka/0000-0002-7879-300X
FU Ministry of Health [364/2021/DA]
FX This research was funded by Ministry of Health in 2021-2025 as part of
   the National Health Program (agreement No. 364/2021/DA of 29 November
   2021).
CR [Anonymous], OB OV
   [Anonymous], WHO | Diabetes
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NR 79
TC 7
Z9 8
U1 0
U2 4
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD AUG
PY 2022
VL 11
IS 15
AR 4314
DI 10.3390/jcm11154314
PG 17
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 3R7YG
UT WOS:000839123000001
PM 35893405
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Onishi, S
   Meguro, S
   Pervin, M
   Kitazawa, H
   Yoto, A
   Ishino, M
   Shimba, Y
   Mochizuki, Y
   Miura, S
   Tokimitsu, I
   Unno, K
AF Onishi, Shintaro
   Meguro, Shinichi
   Pervin, Monira
   Kitazawa, Hidefumi
   Yoto, Ai
   Ishino, Mayu
   Shimba, Yuki
   Mochizuki, Yusuke
   Miura, Shinji
   Tokimitsu, Ichiro
   Unno, Keiko
TI Green Tea Extracts Attenuate Brain Dysfunction in High-Fat-Diet-Fed
   SAMP8 Mice
SO NUTRIENTS
LA English
DT Article
DE aging; green tea extracts; oxidative stress; senescence-accelerated
   mouse prone-8; synaptic plasticity
ID AMYLOID-BETA ACCUMULATION; INSULIN-RESISTANCE; OXIDATIVE STRESS;
   EPIGALLOCATECHIN GALLATE; COGNITIVE DYSFUNCTION; METABOLIC SYNDROME;
   ALZHEIMER-DISEASE; SYNAPSE FORMATION; SEX-DIFFERENCES; PROTEIN-KINASE
AB Unhealthy diet promotes progression of metabolic disorders and brain dysfunction with aging. Green tea extracts (GTEs) have various beneficial effects and alleviate metabolic disorders. GTEs have neuroprotective effects in rodent models, but their effects against brain dysfunction in models of aging fed unhealthy diets are still unclear. Here, we showed that GTEs attenuate high-fat (HF) diet-induced brain dysfunction in senescence-accelerated mouse prone-8 (SAMP8), a murine model of senescence. SAMP8 mice were fed a control diet, HF diet, or HF diet with 0.5% GTEs (HFGT) for four months. The HF diet reduced memory retention and induced amyloid (1-42) accumulation, whereas GTEs attenuated these changes. In HF diet-fed mice, lipid oxidative stress, assessed by malondialdehyde levels, was increased. The levels of proteins that promote synaptic plasticity, such as brain-derived neurotrophic factor (BDNF) and postsynaptic density protein 95 (PSD95), were reduced. These alterations related to brain dysfunction were not observed in HFGT diet-fed mice. Overall, our data suggest that GTEs intake might attenuate brain dysfunction in HF diet-fed SAMP8 mice by protecting synaptic plasticity as well as via anti-oxidative effects. In conclusion, GTEs might ameliorate unhealthy diet-induced brain dysfunction that develops with aging.
C1 [Onishi, Shintaro; Meguro, Shinichi; Kitazawa, Hidefumi] Kao Corp, Biol Sci Res, Ichikai, Tochigi 3213497, Japan.
   [Pervin, Monira; Yoto, Ai; Unno, Keiko] Univ Shizuoka, Tea Sci Ctr, Suruga Ku, Shizuoka 4228526, Japan.
   [Ishino, Mayu; Shimba, Yuki; Mochizuki, Yusuke; Miura, Shinji] Univ Shizuoka, Grad Sch Nutr & Environm Sci, Lab Nutr Biochem, Suruga Ku, Shizuoka 4228526, Japan.
   [Tokimitsu, Ichiro] Univ Human Arts & Sci, Dept Hlth & Food Sci, Iwatsuki Ku, Saitama 3390077, Japan.
   [Unno, Keiko] Univ Shizuoka, Sch Pharmaceut Sci, Dept Neurophysiol, Suruga Ku, Shizuoka 4228526, Japan.
C3 KAO Corporation; University of Shizuoka; University of Shizuoka;
   University of Shizuoka
RP Meguro, S (corresponding author), Kao Corp, Biol Sci Res, Ichikai, Tochigi 3213497, Japan.
EM oonishi.shintarou@kao.com; meguro.shinichi@kao.com;
   gp1747@u-shizuoka-ken.ac.jp; kitazawa.hidefumi@kao.com;
   ai_yoto@hotmail.com; s16213@u-shizuoka-ken.ac.jp;
   s16214@u-shizuoka-ken.ac.jp; s16215@u-shizuoka-ken.ac.jp;
   miura@u-shizuoka-ken.ac.jp; ichiro_tokimitsu@human.ac.jp;
   unno@u-shizuoka-ken.ac.jp
RI Miura, Shinji/K-6516-2013; Shimba, Yuki/AGP-0767-2022
OI Meguro, Shinichi/0000-0002-3072-2632; SHIMBA, Yuki/0000-0001-7995-2220;
   Miura, Shinji/0000-0001-8806-9763
FU Kao Corporation; University of Shizuoka
FX This work was supported by industry-academia collaboration between Kao
   Corporation and the University of Shizuoka. The funder had no role in
   study design, data collection and analysis, preparation of the
   manuscript, or decision to publish.
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NR 62
TC 15
Z9 16
U1 0
U2 15
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 2072-6643
J9 NUTRIENTS
JI Nutrients
PD APR
PY 2019
VL 11
IS 4
AR 821
DI 10.3390/nu11040821
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA HX9SX
UT WOS:000467749800114
PM 30979047
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Dai, FJ
   Hsu, WH
   Huang, JJ
   Wu, SC
AF Dai, Fan-Jhen
   Hsu, Wei-Hsuan
   Huang, Jan-Jeng
   Wu, She-Ching
TI Effect of pigeon pea (Cajanus cajan L.) on high-fat diet-induced
   hypercholesterolemia in hamsters
SO FOOD AND CHEMICAL TOXICOLOGY
LA English
DT Article
DE High-fat diet (HFD); Hyperlipidemia; Obesity; Oxidative stress;
   Phytosterone; Pigeon pea
ID CONJUGATED LINOLEIC-ACID; LOW-DENSITY-LIPOPROTEIN; CHOLESTEROL
   PRECURSORS; PLANT STEROLS; EXTRACT; SEEDS
AB Obesity is associated with increased systemic and airway oxidative stress, which may result from a combination of adipokine imbalance and antioxidant defenses reduction. Obesity-mediated oxidative stress plays an important role in the pathogenesis of dyslipidemia, vascular disease, and nonalcoholic hepatic steatosis. The antidyslipidemic activity of pigeon pea were evaluated by high-fat diet (HFD) hamsters model, in which the level of high-density lipoprotein-cholesterol (HDL-C), low-density lipoprotein-cholesterol (LDL-C), total cholesterol (TC), and total triglyceride (TG) were examined. We found that pigeon pea administration promoted cholesterol converting to bile acid in HFD-induced hamsters, thereby exerting hypolipidemic activity. In the statistical results, pigeon pea significantly increased hepatic carnitine palmitoyltransferase-1 (CPT-1), LDL receptor, and cholesterol 7 alpha-hydroxylase (also known as cytochrome P450 7A1, CYP7A1) expression to attenuate dyslipidemia in HFD-fed hamsters; and markedly elevated antioxidant enzymes in the liver of HFD-induced hamsters, further alleviating lipid peroxidation. These effects may attribute to pigeon pea contained large of unsaturated fatty acids (UFA; C18:2) and phytosterol (beta-sitosterol, campesterol, and stigmasterol). Moreover, the effects of pigeon pea on dyslipidemia were greater than beta-sitosterol administration (4%), suggesting that phytosterone in pigeon pea could prevent metabolic syndrome. (c) 2012 Elsevier Ltd. All rights reserved.
C1 [Dai, Fan-Jhen; Hsu, Wei-Hsuan; Huang, Jan-Jeng; Wu, She-Ching] Natl Chiayi Univ, Coll Life Sci, Dept Food Sci, Chiayi 60004, Taiwan.
C3 National Chiayi University
RP Wu, SC (corresponding author), Natl Chiayi Univ, Coll Life Sci, Dept Food Sci, 300 Syue Fu Rd, Chiayi 60004, Taiwan.
EM scwu@mail.ncyu.edu.tw
RI Hsu, WeiHsuan/KFQ-3566-2024
FU Council of Agriculture, ROC [DOH098-TD-F-113-098018]
FX This research work and subsidiary spending were supported by the Council
   of Agriculture, ROC, under Grant DOH098-TD-F-113-098018.
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NR 41
TC 35
Z9 39
U1 2
U2 43
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0278-6915
EI 1873-6351
J9 FOOD CHEM TOXICOL
JI Food Chem. Toxicol.
PD MAR
PY 2013
VL 53
BP 384
EP 391
DI 10.1016/j.fct.2012.12.029
PG 8
WC Food Science & Technology; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Toxicology
GA 198LP
UT WOS:000322924700053
PM 23287313
DA 2025-06-11
ER

PT J
AU Couillard, C
   Ruel, G
   Archer, WR
   Pomerleau, S
   Bergeron, J
   Couture, P
   Lamarche, B
   Bergeron, N
AF Couillard, C
   Ruel, G
   Archer, WR
   Pomerleau, S
   Bergeron, J
   Couture, P
   Lamarche, B
   Bergeron, N
TI Circulating levels of oxidative stress markers and endothelial adhesion
   molecules in men with abdominal obesity
SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Article
ID LOW-DENSITY-LIPOPROTEIN; C-REACTIVE PROTEIN; INSULIN-RESISTANCE;
   E-SELECTIN; METABOLIC SYNDROME; PLASMA-GLUCOSE; RISK; DISEASE; LDL;
   SUSCEPTIBILITY
AB Context: It has been suggested that oxidative stress and endothelial dysfunction could play a role in the higher cardiovascular disease risk noted in the abdominally obese population.
   Objective: The objective of this study was to describe the associations between abdominal fat accumulation, oxidative stress, and endothelial dysfunction in men.
   Design: A complete physical and metabolic profile was assessed in a group of 56 men covering a wide range of adiposity and plasma oxidized low-density lipoprotein (OxLDL), and soluble intercellular adhesion molecule-1, soluble vascular cell adhesion molecule-1, E-selectin, and C-reactive protein concentrations were determined.
   Results: We found that abdominal visceral adipose tissue was positively associated with plasma OxLDL (r = 0.52; P < 0.0001) and C-reactive protein (r = 0.60; P < 0.0001) concentrations. We also found significant associations between plasma E-selectin levels and hyperinsulinemia (r = 0.39; P < 0.005) as well as with the homeostasis model assessment index of insulin resistance (r = 0.42; P < 0.005).
   Conclusions: Our study showed that plasma OxLDL levels and low-grade systemic inflammation are increased in men with a high visceral adipose tissue accumulation. Furthermore, our results support the notion that insulin resistance is associated with endothelial activation. Overall, our observations give us further insights on the increased cardiovascular disease risk frequently noted among viscerally obese, insulin-resistant individuals.
C1 Univ Laval, Inst Nutraceut & Funct Foods, Ste Foy, PQ G1K 7P4, Canada.
   Univ Laval, Dept Food Sci & Nutr, Ste Foy, PQ G1K 7P4, Canada.
   Univ Laval, Lipid Res Ctr, Med Ctr, Quebec City, PQ G1V 4G2, Canada.
C3 Laval University; Laval University; Laval University
RP Univ Laval, Inst Nutraceut & Funct Foods, 2440 Blvd Hochelaga,Room 2742, Ste Foy, PQ G1K 7P4, Canada.
EM charles.couillard@inaf.ulaval.ca
RI Lamarche, Benoit/ABA-4785-2021; bergeron, nathalie/AGF-2970-2022
OI Couture, Patrick/0000-0002-8414-3847; Couillard,
   Charles/0000-0002-6281-8663; Lamarche, Benoit/0000-0002-4443-5378
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NR 48
TC 155
Z9 167
U1 0
U2 2
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0021-972X
EI 1945-7197
J9 J CLIN ENDOCR METAB
JI J. Clin. Endocrinol. Metab.
PD DEC
PY 2005
VL 90
IS 12
BP 6454
EP 6459
DI 10.1210/jc.2004-2438
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 990OV
UT WOS:000233754000018
PM 16189262
OA Bronze
DA 2025-06-11
ER

PT J
AU Alwahsh, SM
   Xu, M
   Seyhan, HA
   Ahmad, S
   Mihm, S
   Ramadori, G
   Schultze, FC
AF Alwahsh, Salamah Mohammad
   Xu, Min
   Seyhan, Hatice Ali
   Ahmad, Shakil
   Mihm, Sabine
   Ramadori, Giuliano
   Schultze, Frank Christian
TI Diet high in fructose leads to an overexpression of lipocalin-2 in rat
   fatty liver
SO WORLD JOURNAL OF GASTROENTEROLOGY
LA English
DT Article
DE Non-alcoholic fatty liver disease; Inflammation; Endotoxins;
   Lipopolysaccharide; Oxidative stress; Mitochondrial dysfunction;
   Metabolic syndrome
ID ACUTE-PHASE PROTEIN; INSULIN-RESISTANCE; NONALCOHOLIC STEATOHEPATITIS;
   METABOLIC SYNDROME; LIPID-PEROXIDATION; HEPATIC STEATOSIS; KAPPA-B;
   OBESITY; DISEASE; MACROPHAGES
AB AIM: To explore lipocalin-2 (LCN-2) expression and its possible role and mechanism(s) of production in rat models of diet-inducible fatty liver.
   METHODS: Fatty liver was triggered in male Sprague-Dawley rats fed either with liquid Lieber-DeCarli (LDC) or LDC + 70% cal fructose (L-HFr) diet for 4 or 8 wk. Chow-nourished animals served as controls. Hepatic expression of LCN-2 and other metabolic and inflammatory mediators was assessed by quantitative reverse transcription polymerase chain reaction and Western blotting. Serum LCN-2, fasting leptin, and lipid profile were evaluated via Enzyme-Linked Immunosorbent Assay, Radioimmunoassay, and colorimetric assays, respectively. The localization of LCN-2 in the liver was detected by using immunofluorescence staining. Furthermore, HE stain was used to evaluate hepatic fat degeneration and inflammation.
   RESULTS: Both LDC-fed and L-HFr-fed rat histologically featured fatty liver. In the liver, mRNA transcriptions of Mcp-1, a2-m, Il-8 and Glut5 were increased in the L-HFr group at both time points (P < 0.001), while the transcription of Tlr4, Inos, and Tnf-alpha was significantly up-regulated at week 4. Interestingly, hepatic Lcn-2 expression was 90-fold at week 4 and 507-fold at week 8 higher in L-HFr-subjected rats vs control (P < 0.001). In contrast to HDL-cholesterol, systemic levels of LCN-2, fasting leptin and triglycerides were elevated in the L-HFr regimen (P < 0.001). Moreover, protein expression of hepatic LCN-2, CD14, phospho-MAPK, caspase-9, cytochrome c and 4-hydroxynonenal was increased in the L-HFr group. Conversely, the hepatic expression of PGC-1 alpha (a mitochondrial-biogenic protein) was reduced in the L-HFr category at week 8. The localization of LCN-2 in the liver was predominantly restricted to MPO+ granulocytes.
   CONCLUSION: Fructose diet up-regulates hepatic LCN-2 expression, which correlates with the increased indicators of oxidative stress and mitochondrial dysfunction. The LCN-2 may be involved in liver protection. (C) 2014 Baishideng Publishing Group Co., Limited. All rights reserved.
C1 [Alwahsh, Salamah Mohammad; Seyhan, Hatice Ali; Ahmad, Shakil; Mihm, Sabine; Ramadori, Giuliano; Schultze, Frank Christian] Univ Med Ctr Goettingen, Dept Gastroenterol & Endocrinol, D-37075 Gottingen, Germany.
   [Xu, Min] Univ Med Ctr Goettingen, Dept Gen Visceral & Pediat Surg, D-37075 Gottingen, Germany.
C3 University of Gottingen; UNIVERSITY GOTTINGEN HOSPITAL; University of
   Gottingen; UNIVERSITY GOTTINGEN HOSPITAL
RP Schultze, FC (corresponding author), Univ Med Ctr Goettingen, Dept Gastroenterol & Endocrinol, Robert Koch Str 40, D-37075 Gottingen, Germany.
EM f.schultze@med.uni-goettingen.de
RI Xu, Min/AFQ-4402-2022
OI Xu, Min/0000-0002-0934-1237; Seyhan Kutluay, Hatice/0000-0002-0766-9159
FU German Research Foundation; Gottingen University
FX The authors appreciate Prof. Dr. med. Tilman Sauerbruch, Dept. of
   Gastroenterology and Endocrinology, UMG, and Prof. Dr. Uwe Gross,
   Institute for Medical Microbiology, Faculty of Medicine,
   Georg-August-University, Goettingen, Germany for the critical advising
   and reviewing the study. This research did not receive any specific
   grant from any funding agency in the public, commercial, or
   not-for-profit sector. We also acknowledge support by the German
   Research Foundation and the Open Access Publication Funds of the
   Gottingen University.
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NR 42
TC 74
Z9 80
U1 1
U2 13
PU BAISHIDENG PUBL GRP CO LTD
PI WANCHAI
PA ROOM 1701, 17-F, HENAN BUILDING, NO. 90, JAFFE RD, WANCHAI, HONG KONG
   100025, PEOPLES R CHINA
SN 1007-9327
EI 2219-2840
J9 WORLD J GASTROENTERO
JI World J. Gastroenterol.
PD FEB 21
PY 2014
VL 20
IS 7
BP 1807
EP 1821
DI 10.3748/wjg.v20.i7.1807
PG 15
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA AB7JO
UT WOS:000331966100016
PM 24587658
OA Green Published, Green Submitted, hybrid
DA 2025-06-11
ER

PT J
AU Schaffert, A
   Arnold, J
   Karkossa, I
   Blüher, M
   von Bergen, M
   Schubert, K
AF Schaffert, Alexandra
   Arnold, Josi
   Karkossa, Isabel
   Blueher, Matthias
   von Bergen, Martin
   Schubert, Kristin
TI The Emerging Plasticizer Alternative DINCH and Its Metabolite MINCH
   Induce Oxidative Stress and Enhance Inflammatory Responses in Human
   THP-1 Macrophages
SO CELLS
LA English
DT Article
DE DINCH; plasticizer; macrophage; proteomics; immunotoxicity
ID VASCULAR FRACTION DIFFERENTIATION; ENDOCRINE DISRUPTING CHEMICALS;
   ARYL-HYDROCARBON RECEPTOR; ACID DIISONONYL ESTER; IMMUNE-SYSTEM;
   BISPHENOL-A; AUTOPHAGY; TOXICITY; CELLS; ACTIVATION
AB The use of the plasticizer bis(2-ethylhexyl)phthalate (DEHP) and other plasticizers in the manufacture of plastic products has been restricted due to adverse health outcomes such as obesity, metabolic syndrome, and asthma, for which inflammation has been described to be a driving factor. The emerging alternative plasticizer 1,2-cyclohexanedioic acid diisononyl ester (DINCH) still lacks information regarding its potential effects on the immune system. Here, we investigated the effects of DINCH and its naturally occurring metabolite monoisononylcyclohexane-1,2-dicarboxylic acid ester (MINCH) on the innate immune response. Human THP-1 macrophages were exposed to 10 nM-10 mu M DINCH or MINCH for 4 h, 16 h, and 24 h. To decipher the underlying mechanism of action, we applied an untargeted proteomic approach that revealed xenobiotic-induced activation of immune-related pathways such as the nuclear factor kappa B (NF-kappa B) signaling pathway. Key drivers were associated with oxidative stress, mitochondrial dysfunction, DNA damage repair, apoptosis, and autophagy. We verified increased reactive oxygen species (ROS) leading to cellular damage, NF-kappa B activation, and subsequent TNF and IL-1 beta release, even at low nM concentrations. Taken together, DINCH and MINCH induced cellular stress and pro-inflammatory effects in macrophages, which may lead to adverse health effects.
C1 [Schaffert, Alexandra; Arnold, Josi; Karkossa, Isabel; von Bergen, Martin; Schubert, Kristin] UFZ Helmholtz Ctr Environm Res, Dept Mol Syst Biol, D-04318 Leipzig, Germany.
   [Blueher, Matthias] Helmholtz Inst Metab Obes & Vasc Res HIMAG, D-04318 Leipzig, Germany.
   [Blueher, Matthias] Univ Hosp Leipzig, Dept Endocrinol, Nephrol Rheumatol, Med Res Ctr, D-04318 Leipzig, Germany.
   [von Bergen, Martin] Univ Leipzig, Inst Biochem, D-04103 Leipzig, Germany.
C3 Helmholtz Association; Helmholtz Center for Environmental Research
   (UFZ); Leipzig University; Leipzig University
RP Schubert, K (corresponding author), UFZ Helmholtz Ctr Environm Res, Dept Mol Syst Biol, D-04318 Leipzig, Germany.
EM alexandra.schaffert@ufz.de; josi.arnold@ufz.de; isabel.karkossa@ufz.de;
   matthias.blueher@uniklinik-leipzig.de; martin.vonbergen@ufz.de;
   kristin.schubert@ufz.de
RI Karkossa, Isabel/AAH-1809-2021; Schubert, Kristin/AAB-6438-2020; von
   Bergen, Martin/D-7960-2011
OI Schaffert, Alexandra/0000-0001-8159-1292; von Bergen,
   Martin/0000-0003-2732-2977; Schubert, Kristin/0000-0003-4365-084X;
   Arnold, Josi/0000-0002-8381-918X; Karkossa, Isabel/0000-0003-2781-1877
FU German Federal Environmental Foundation (DBU); research unit CITE of the
   Helmholtz-Centre for Environmental Research (UFZ); German Research
   Council (DFG) [SFB 1052/3]; UFZ
FX This research was funded by the German Federal Environmental Foundation
   (DBU) as a personal fellowship of Alexandra Schaffert. Josi Arnold is
   grateful for funding by the research unit CITE of the Helmholtz-Centre
   for Environmental Research (UFZ). Martin von Bergen and Kristin Schubert
   are grateful for support by the UFZ-funded platform ProMetheus for
   proteome and metabolome analysis. Martin von Bergen and Matthias Bluher
   are thankful for funding by the German Research Council (DFG) for the
   Clinical Research Center "Obesity Mechanisms" SFB 1052/3 (B1, Z3).
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NR 84
TC 29
Z9 30
U1 5
U2 39
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2073-4409
J9 CELLS-BASEL
JI Cells
PD SEP
PY 2021
VL 10
IS 9
AR 2367
DI 10.3390/cells10092367
PG 19
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA UV4RQ
UT WOS:000699468100001
PM 34572016
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Jang, K
   Shin, G
   Yoo, HJ
   Lee, JH
   Kim, M
AF Jang, Kyunghye
   Shin, Gurum
   Yoo, Hye Jin
   Lee, Jong Ho
   Kim, Minjoo
TI Risk Associated with the LEPR rs8179183 GG Genotype in a Female
   Korean Population with Obesity
SO ANTIOXIDANTS
LA English
DT Article
DE metabolically healthy obesity; metabolically unhealthy obesity; leptin
   receptor gene; female; Korean population
ID LEPTIN RECEPTOR GENE; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   BODY-COMPOSITION; FAT DISTRIBUTION; NORMAL-WEIGHT; POLYMORPHISMS;
   HYPERTENSION; PROFILES; CHILDREN
AB The difference between metabolically healthy obesity (MHO) and metabolically unhealthy obesity (MUO) phenotypes might be partly attributable to genetic traits modulating body fat distribution and other obesity-related metabolic traits, specifically with regard toLEPRrs8179183 in Korean women with obesity. A total of 177 females with obesity participated in the study and were grouped by genotype (GC or GG) and metabolic health status (MHO and MUO). Between the MHO and MUO groups, significant differences were found in waist circumference, waist-to-hip ratio, lipid profiles, glucose-related markers, biomarkers of liver health, adiponectin, oxidative stress markers, whole fat area (WFA), and subcutaneous fat area (SFA) at the level of the L1 vertebra, and WFA and visceral fat area (VFA) at the level of the L4 vertebra. Lipid profiles, glucose-related markers, adipokines, oxidative stress markers, and WFA and VFA at the L4 level were significantly different between the GC and GG genotypes. Notably, the individuals with the MUO phenotype and the GG genotype had the least favorable values of glucose-related markers, lipid profiles, adipokines, oxidative stress markers, and regional fat distribution. These observations suggest that the development of obesity-related metabolic traits is highly associated not only with the rs8179183 genotype but also with metabolic status in Korean females with obesity.
C1 [Jang, Kyunghye; Shin, Gurum; Yoo, Hye Jin; Lee, Jong Ho] Yonsei Univ, Coll Human Ecol, Dept Food & Nutr, Natl Leading Res Lab Clin Nutrigenet Nutrigen, Seoul 03722, South Korea.
   [Yoo, Hye Jin; Lee, Jong Ho] Yonsei Univ, Inst Symbiot Life TECH, Res Ctr Silver Sci, Seoul 03722, South Korea.
   [Kim, Minjoo] Hannam Univ, Coll Life Sci & Nano Technol, Dept Food & Nutr, Daejeon 34054, South Korea.
C3 Yonsei University; Yonsei University; Hannam University
RP Kim, M (corresponding author), Hannam Univ, Coll Life Sci & Nano Technol, Dept Food & Nutr, Daejeon 34054, South Korea.
EM jkh911127@naver.com; gloria1261@naver.com; hyejin10432@hanmail.net;
   jhleeb@yonsei.ac.kr; minjookim@hnu.kr
RI Kim, Minjoo/AEN-5516-2022
OI YOO, HYE JIN/0000-0003-2075-0426; Shin, Gurum/0000-0003-0437-1434
FU Basic Science Research Program through the National Research Foundation
   of Korea (NRF) - Ministry of Science and ICT [NRF-2017R1C1B2007195];
   Ministry of Education [NRF-2019R1I1A2A01061731]
FX This research was supported by the Basic Science Research Program
   through the National Research Foundation of Korea (NRF), funded by the
   Ministry of Science and ICT (NRF-2017R1C1B2007195) and the Ministry of
   Education (NRF-2019R1I1A2A01061731).
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NR 27
TC 1
Z9 1
U1 0
U2 1
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD JUN
PY 2020
VL 9
IS 6
AR 497
DI 10.3390/antiox9060497
PG 10
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA MR5OG
UT WOS:000553636100001
PM 32517169
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Sugimoto, M
   Arai, H
   Tamura, Y
   Murayama, T
   Khaengkhan, P
   Nishio, T
   Ono, K
   Ariyasu, H
   Akamizu, T
   Ueda, Y
   Kita, T
   Harada, S
   Kamei, K
   Yokode, M
AF Sugimoto, Masayuki
   Arai, Hidenori
   Tamura, Yukinori
   Murayama, Toshinori
   Khaengkhan, Parinda
   Nishio, Takuya
   Ono, Koh
   Ariyasu, Hiroyuki
   Akamizu, Takashi
   Ueda, Yukihiko
   Kita, Toru
   Harada, Shigeharu
   Kamei, Kaeko
   Yokode, Masayuki
TI Mulberry leaf ameliorates the expression profile of adipocytokines by
   inhibiting oxidative stress in white adipose tissue in db/db mice
SO ATHEROSCLEROSIS
LA English
DT Article
DE Macrophage; Adipocytokine; Oxidative stress; Insulin resistance; Obesity
ID HEPATIC STEATOSIS; PPAR-GAMMA; OBESITY; ATHEROSCLEROSIS; ADIPONECTIN;
   PROTEIN; LEAVES; ALPHA; ACID
AB Previous study showed that mulberry (Morus Alba L.) leaf (ML) ameliorates atherosclerosis in apoE(-/-) mice. Although the adipocytokine dysregulation is an important risk factor for atherosclerotic cardiovascular disease, the effect of ML on metabolic disorders related to adipocytokine dysregulation and inflammation has not been studied. Therefore, we studied the effects of ML in metabolic disorders and examined the mechanisms by which ML ameliorates metabolic disorders in db/db mice. We treated db/db mice with ML, pioglitazone, or both for 12 weeks and found that ML decreased blood glucose and plasma triglyceride. Co-treatment with ML and pioglitazone showed additive effects compared with pioglitazone. Moreover, their co-treatment attenuated the body weight increase observed under the pioglitazone treatment. ML treatment also increased the expression of adiponectin, and decreased the expression of TNF-alpha, MCP-1, and macrophage markers in white adipose tissue (WAT). Furthermore, ML decreased lipid peroxides and the expression of NADPH oxidase subunits in WAT and liver. Their co-treatment enhanced these effects. Thus, ML ameliorates adipocytokine dysregulation at least in part through inhibiting oxidative stress in WAT of db/db mice, and that ML may be a basis for a pharmaceutical for the treatment of the metabolic syndrome as well as reducing adverse effects of pioglitazone. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
C1 [Arai, Hidenori] Kyoto Univ, Grad Sch Med, Dept Geriatr Med, Kyoto, Japan.
   [Sugimoto, Masayuki; Tamura, Yukinori; Murayama, Toshinori; Yokode, Masayuki] Kyoto Univ, Grad Sch Med, Dept Clin Innovat Med, Kyoto, Japan.
   [Ono, Koh; Kita, Toru] Kyoto Univ, Grad Sch Med, Dept Cardiovasc Med, Kyoto, Japan.
   [Murayama, Toshinori; Ariyasu, Hiroyuki; Akamizu, Takashi; Yokode, Masayuki] Kyoto Univ Hosp, Translat Res Ctr, Sakyo Ku, Kyoto 6068507, Japan.
   [Ueda, Yukihiko] Keihanna Hosp, Hirakata, Osaka, Japan.
   [Khaengkhan, Parinda; Nishio, Takuya; Harada, Shigeharu; Kamei, Kaeko] Kyoto Inst Technol, Dept Appl Biol, Grad Sch Sci & Technol, Sakyo Ku, Kyoto 6068585, Japan.
C3 Kyoto University; Kyoto University; Kyoto University; Kyoto University;
   Kyoto Institute of Technology
RP Arai, H (corresponding author), Kyoto Univ, Grad Sch Med, Dept Geriatr Med, Kyoto, Japan.
EM harai@kuhp.kyoto-u.ac.jp
RI ; Arai, Hidenori/P-9816-2017
OI Akamizu, Takashi/0000-0003-4960-8271; Arai,
   Hidenori/0000-0002-9000-6849; Sugimoto, Masayuki/0000-0002-1439-4739;
   Khaengkhan, Parinda/0000-0003-3202-9070
FU Ministry of Education, Science, Sports, Culture, and Technology of
   Japan; Japanese Ministry of Health and Welfare; Grants-in-Aid for
   Scientific Research [21590592] Funding Source: KAKEN
FX We thank Ms. Ayumi Hosotani (Kyoto University) for excellent technical
   assistance, Dr. Masaru Iwai (Ehime University) for advice for our
   experiment. This study was supported by Grants-inAid from the Ministry
   of Education, Science, Sports, Culture, and Technology of Japan and a
   research grant for health sciences from the Japanese Ministry of Health
   and Welfare.
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NR 26
TC 47
Z9 50
U1 6
U2 22
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0021-9150
EI 1879-1484
J9 ATHEROSCLEROSIS
JI Atherosclerosis
PD JUN
PY 2009
VL 204
IS 2
BP 388
EP 394
DI 10.1016/j.atherosclerosis.2008.10.021
PG 7
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 460PW
UT WOS:000267200600014
PM 19070857
DA 2025-06-11
ER

PT J
AU Castanon, N
   Lasselin, J
   Capuron, L
AF Castanon, Nathalie
   Lasselin, Julie
   Capuron, Lucile
TI Neuropsychiatric comorbidity in obesity: role of inflammatory processes
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Review
DE obesity; inflammation; neuroinflammation; cytokines; gut-brain axis;
   mood; cognition; neuropsychiatric symptoms
ID HIGH-FAT DIET; DEPRESSIVE-LIKE BEHAVIOR; LOW-GRADE INFLAMMATION;
   C-REACTIVE PROTEIN; BODY-MASS INDEX; ANXIETY-LIKE BEHAVIORS; METABOLIC
   SYNDROME; GUT MICROBIOTA; WEIGHT-LOSS; INDOLEAMINE 2,3-DIOXYGENASE
AB Neuropsychiatric symptoms are frequent in obesity. In addition to their substantial economic and health impact, these symptoms significantly interfere with the quality of life and social function of obese individuals. While the pathophysiological mechanisms underlying obesity-related neuropsychiatric symptoms are still under investigation and remain to be clearly identified, there is increasing evidence for a role of inflammatory processes. Obesity is characterized by a chronic low-grade inflammatory state that is likely to influence neuropsychiatric status given the well-known and highly documented effects of inflammation on brain activity/function and behavior. This hypothesis is supported by recent findings emanating from clinical investigations in obese subjects and from experimentations conducted in animal models of obesity. These studies converge to show that obesity-related inflammatory processes, originating either from the adipose tissue or gut microbiota environment, spread to the brain where they lead to substantial changes in neurocircuitry, neuroendocrine activity, neurotransmitter metabolism and activity, and neurogenesis. Together, these alterations contribute to shape the propitious bases for the development of obesity-related neuropsychiatric comorbidities.
C1 [Castanon, Nathalie; Lasselin, Julie; Capuron, Lucile] French Natl Inst Agr Res INRA, Lab Nutr & Integrat Neurobiol NutriNeuro, UMR 1286, Bordeaux, France.
   [Castanon, Nathalie; Lasselin, Julie; Capuron, Lucile] Univ Bordeaux, Lab Nutr & Integrat Neurobiol NutriNeuro, UMR 1286, Bordeaux, France.
   [Lasselin, Julie] Stockholm Univ, Stress Res Inst Stress Forskningsinst, S-10691 Stockholm, Sweden.
C3 Institut National de la Sante et de la Recherche Medicale (Inserm);
   INRAE; Universite de Bordeaux; Institut National de la Sante et de la
   Recherche Medicale (Inserm); Universite de Bordeaux; Stockholm
   University
RP Capuron, L (corresponding author), Univ Bordeaux, INRA, Lab Nutr & Integrat Neurobiol NutriNeuro, UMR 1286, 146 Rue Leo Saignat, F-33076 Bordeaux, France.
EM lucile.capuron@bordeaux.inra.fr
RI Lasselin, Julie/I-4316-2019
OI Capuron, Lucile/0000-0002-2060-5918; Castanon,
   Nathalie/0000-0002-0079-0562; Lasselin, Julie/0000-0001-8323-0714
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NR 139
TC 139
Z9 149
U1 0
U2 17
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PY 2014
VL 5
AR 74
DI 10.3389/fendo.2014.00074
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA V44LF
UT WOS:000209749800076
PM 24860551
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Gonda, X
   Pompili, M
   Serafini, G
   Montebovi, F
   Campi, S
   Dome, P
   Duleba, T
   Girardi, P
   Rihmer, Z
AF Gonda, Xenia
   Pompili, Maurizio
   Serafini, Gianluca
   Montebovi, Franco
   Campi, Sandra
   Dome, Peter
   Duleba, Timea
   Girardi, Paolo
   Rihmer, Zoltan
TI Suicidal behavior in bipolar disorder: Epidemiology, characteristics and
   major risk factors
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Review
DE Suicide; Suicide attempt; Bipolar disorder; Risk factors
ID TREATMENT ENHANCEMENT PROGRAM; DEPRESSIVE MIXED-STATE; 1ST 500
   PARTICIPANTS; CLINICAL PREDICTORS; METABOLIC SYNDROME; COMPLETED
   SUICIDE; ANXIETY DISORDERS; ATTEMPT HISTORY; EARLY-ONSET; COMORBIDITY
AB Background: Suicide is one of the leading causes of death and a major public health problem worldwide, and the majority of suicide attempters and completers suffer from some major affective disorder at the time of their death, which, in the majority of cases is unrecognized, under- or misdiagnosed and untreated.
   Methods: Based on a systematic literature search, the authors give a detailed and critical overview of established risk factors of suicide in bipolar disorder.
   Results: Among affective disorders, bipolar disorder carries the highest risk of suicide, yet not all bipolar patients commit or even attempt suicide during their illness. While the general suicide risk factors also apply for bipolar disorders, there are several disease-specific risk factors as well which should be taken into account when evaluating suicide risk in case of patients.
   Conclusion: It is crucial to identify suicide risk factors in bipolar disorder to be able to differentiate those patients within this already increased-risk illness group who are at especially high risk and therefore to allow for better prediction and prevention of suicidal acts. (C) 2012 Elsevier B.V. All rights reserved.
C1 [Gonda, Xenia; Dome, Peter; Duleba, Timea; Rihmer, Zoltan] Semmelweis Univ, Dept Clin & Theoret Mental Hlth, Kutvolgyi Clin Ctr, H-1125 Budapest, Hungary.
   [Gonda, Xenia] Semmelweis Univ, Dept Pharmacodynam, H-1089 Budapest, Hungary.
   [Pompili, Maurizio; Serafini, Gianluca; Montebovi, Franco; Campi, Sandra; Girardi, Paolo] Univ Roma La Sapienza, St Andrea Hosp, Suicide Prevent Ctr, Dept Neurosci Mental Hlth & Sensory Funct, I-00189 Rome, Italy.
   [Pompili, Maurizio] Harvard Univ, McLean Hosp, Sch Med, Belmont, MA 02478 USA.
C3 Semmelweis University; Semmelweis University; Sapienza University Rome;
   Azienda Ospedaliera Sant'Andrea; Harvard University; Harvard University
   Medical Affiliates; McLean Hospital
RP Gonda, X (corresponding author), Semmelweis Univ, Dept Clin & Theoret Mental Hlth, Kutvolgyi Clin Ctr, Kutvolgyi Ut 4, H-1125 Budapest, Hungary.
EM kendermagos@yahoo.com
RI Pompili, Maurizio/AAC-1011-2019; Gonda, Xenia/B-2713-2008; Serafini,
   Gianluca/K-6603-2016
OI Pompili, Maurizio/0000-0003-1886-4977; Gonda, Xenia/0000-0001-9015-4203;
   Serafini, Gianluca/0000-0002-6631-856X
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NR 115
TC 164
Z9 174
U1 0
U2 48
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD DEC 20
PY 2012
VL 143
IS 1-3
BP 16
EP 26
DI 10.1016/j.jad.2012.04.041
PG 11
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA 038ZY
UT WOS:000311213800003
PM 22763038
DA 2025-06-11
ER

PT J
AU Tsamesidis, I
   Kalogianni, EP
AF Tsamesidis, Ioannis
   Kalogianni, Eleni P.
TI The In Vitro, Ex Vivo, and In Vivo Effect of Edible Oils: A Review on
   Cell Interactions
SO PHARMACEUTICS
LA English
DT Review
DE cytotoxicity; fish oils; vegetable oils; seed oils; edible oils;
   oxidative stress biomarkers; antioxidant properties; in vitro models; ex
   vivo; in vivo studies
ID OXIDATIVE STRESS; FISH-OIL; OLIVE OIL; COCONUT OIL; SEED OIL;
   DOCOSAHEXAENOIC ACID; PHENOLIC-COMPOUNDS; DIETARY FATS; DOUBLE-BLIND;
   SUPPLEMENTATION
AB Consumption of edible oils is a significant part of the dietary pattern in the developed and developing world. Marine and vegetable oils are assumed to be part of a healthy food pattern, especially if one takes into account their potential role in protecting against inflammation, cardiovascular disease, and metabolic syndrome due to the presence of polyunsaturated fatty acids and minor bioactive compounds. Exploring the potential effect of edible fats and oils on health and chronic diseases is an emerging field worldwide. This study reviews the current knowledge of the in vitro, ex vivo, and in vivo effect of edible oils in contact with various cell types and aims to demonstrate which nutritional and bioactive components of a variety of edible oils present biocompatibility, antimicrobial properties, antitumor activity, anti-angiogenic activity, and antioxidant activity. Through this review, a wide variety of cell interactions with edible oils and their potential to counteract oxidative stress in pathological conditions are presented as well. Moreover, the gaps in current knowledge are also highlighted, and future perspectives on edible oils and their health benefits and potential to counteract a wide variety of diseases through possible molecular mechanisms are also discussed.
C1 [Tsamesidis, Ioannis; Kalogianni, Eleni P.] Int Hellen Univ, Dept Food Sci & Technol, Sindos Campus, Thessaloniki 57400, Greece.
C3 International Hellenic University
RP Kalogianni, EP (corresponding author), Int Hellen Univ, Dept Food Sci & Technol, Sindos Campus, Thessaloniki 57400, Greece.
EM elekalo@ihu.gr
RI Kalogianni, Eleni/J-4271-2013; TSAMESIDIS, IOANNIS/AAL-7655-2021
OI Tsamesidis, Ioannis/0000-0002-1439-3920
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NR 122
TC 5
Z9 5
U1 4
U2 30
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1999-4923
J9 PHARMACEUTICS
JI Pharmaceutics
PD MAR
PY 2023
VL 15
IS 3
AR 869
DI 10.3390/pharmaceutics15030869
PG 21
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA A9QB4
UT WOS:000958380200001
PM 36986730
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Studzinski, CM
   Li, F
   Bruce-Keller, AJ
   Fernandez-Kim, SO
   Zhang, L
   Weidner, AM
   Markesbery, WR
   Murphy, MP
   Keller, JN
AF Studzinski, Christa M.
   Li, Feng
   Bruce-Keller, Annadora J.
   Fernandez-Kim, Sun Ok
   Zhang, Le
   Weidner, Adam M.
   Markesbery, William R.
   Murphy, M. Paul
   Keller, Jeffrey N.
TI Effects of short-term Western diet on cerebral oxidative stress and
   diabetes related factors in APP x PS1 knock-in mice
SO JOURNAL OF NEUROCHEMISTRY
LA English
DT Article
DE adipokine; Alzheimer's disease; amyloid-beta; protein oxidation; Western
   diet
ID MANGANESE SUPEROXIDE-DISMUTASE; POLYUNSATURATED FATTY-ACIDS;
   ALZHEIMERS-DISEASE; AMYLOID DEPOSITION; MITOCHONDRIAL DYSFUNCTION;
   METABOLIC SYNDROME; PROTEIN OXIDATION; 2-HIT HYPOTHESIS; MOUSE MODEL;
   BETA
AB A chronic high fat Western diet (WD) promotes a variety of morbidity factors although experimental evidence for short-term WD mediating brain dysfunction remains to be elucidated. The amyloid precursor protein and presenilin-1 (APP x PS1) knock-in mouse model has been demonstrated to recapitulate some key features of Alzheimer's disease pathology, including amyloid-beta (A beta) pathogenesis. In this study, we placed 1-month-old APP x PS1 mice and non-transgenic littermates on a WD for 4 weeks. The WD resulted in a significant elevation in protein oxidation and lipid peroxidation in the brain of APP x PS1 mice relative to non-transgenic littermates, which occurred in the absence of increased A beta levels. Altered adipokine levels were also observed in APP x PS1 mice placed on a short-term WD, relative to non-transgenic littermates. Taken together, these data indicate that short-term WD is sufficient to selectively promote cerebral oxidative stress and metabolic disturbances in APP x PS1 knock-in mice, with increased oxidative stress preceding alterations in A beta. These data have important implications for understanding how WD may potentially contribute to brain dysfunction and the development of neurodegenerative disorders such as Alzheimer's disease.
C1 [Bruce-Keller, Annadora J.; Fernandez-Kim, Sun Ok; Zhang, Le; Keller, Jeffrey N.] Pennington Biomed Res Ctr, LSU Syst, Baton Rouge, LA 70808 USA.
   [Studzinski, Christa M.; Li, Feng; Weidner, Adam M.] Univ Kentucky, Sanders Brown Ctr Aging, Lexington, KY 40536 USA.
   [Weidner, Adam M.; Murphy, M. Paul] Univ Kentucky, Dept Mol & Cellular Biochem, Lexington, KY 40536 USA.
   [Markesbery, William R.] Univ Kentucky, Dept Pathol, Lexington, KY 40536 USA.
C3 Louisiana State University System; Louisiana State University;
   Pennington Biomedical Research Center; University of Kentucky;
   University of Kentucky; University of Kentucky
RP Keller, JN (corresponding author), Pennington Biomed Res Ctr, LSU Syst, 6400 Perkins Rd, Baton Rouge, LA 70808 USA.
EM Mpmurp3@email.uky.edu; jeffrey.keller@pbrc.edu
RI Li, Feng/JUV-5728-2023; Murphy, Michael/C-2120-2009; Bruce-Keller,
   Annadora/N-1954-2017; Keller, Jeffrey/N-1975-2017
OI keller, jeffrey/0000-0002-9892-7423; Studzinski,
   Christa/0009-0004-8513-0337
FU NIA; NCRR [RR020171]; NINDS [NS058382]; Alzheimer's Association
FX This work was supported by funds from the NIA (MPM, AJBK, WRM, JNK),
   NCRR (RR020171 to MPM), NINDS (NS058382 to MPM), Alzheimer's Association
   (JNK), R. C Durr Endowed Chair (JNK), and a fellowship from the Myositis
   Association (CMS). The authors thank Dr Daret St Clair (University of
   Kentucky) for assistance with maintaining the mouse colony and
   assistance genotyping the animals.
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NR 42
TC 68
Z9 72
U1 2
U2 20
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-3042
EI 1471-4159
J9 J NEUROCHEM
JI J. Neurochem.
PD FEB
PY 2009
VL 108
IS 4
BP 860
EP 866
DI 10.1111/j.1471-4159.2008.05798.x
PG 7
WC Biochemistry & Molecular Biology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Neurosciences & Neurology
GA 395IF
UT WOS:000262517100002
PM 19046405
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Cortés-Espinar, AJ
   Ibarz-Blanch, N
   Soliz-Rueda, JR
   Bonafos, B
   Feillet-Coudray, C
   Casas, F
   Bravo, FI
   Calvo, E
   Avila-Román, J
   Mulero, M
AF Cortes-Espinar, Antonio J.
   Ibarz-Blanch, Nestor
   Soliz-Rueda, Jorge R.
   Bonafos, Beatrice
   Feillet-Coudray, Christine
   Casas, Francois
   Bravo, Francisca Isabel
   Calvo, Enrique
   Avila-Roman, Javier
   Mulero, Miquel
TI Rhythm and ROS: Hepatic Chronotherapeutic Features of Grape Seed
   Proanthocyanidin Extract Treatment in Cafeteria Diet-Fed Rats
SO ANTIOXIDANTS
LA English
DT Article
DE oxidative stress; phenolic compounds; proanthocyanidins; GSPE; liver;
   cafeteria diet; diurnal rhythms; circadian rhythms; zeitgeber;
   chronotherapy
ID OXIDATIVE STRESS; CIRCADIAN-CLOCK; GENE-EXPRESSION; METABOLIC SYNDROME;
   OBESITY; ANTIOXIDANT; INFLAMMATION; TRANSLATION; GLUTATHIONE; MODULATE
AB Polyphenols play a key role in the modulation of circadian rhythms, while the cafeteria diet (CAF) is able to perturb the hepatic biological rhythm and induce important ROS production. Consequently, we aimed to elucidate whether grape seed proanthocyanidin extract (GSPE) administration recovers the CAF-induced hepatic antioxidant (AOX) misalignment and characterize the chronotherapeutic properties of GSPE. For this purpose, Fischer 344 rats were fed a standard diet (STD) or a CAF and concomitantly treated with GSPE at two time-points (ZT0 vs. ZT12). Animals were euthanized every 6 h and the diurnal rhythms of hepatic ROS-related biomarkers, hepatic metabolites, and AOX gene expression were examined. Interestingly, GSPE treatment was able to recover the diurnal rhythm lost due to the CAF. Moreover, GSPE treatment also increased the acrophase of Sod1, as well as bringing the peak closer to that of the STD group. GSPE also corrected some hepatic metabolites altered by the CAF. Importantly, the differences observed at ZT0 vs. ZT12 due to the time of GSPE administration highlight a chronotherapeutic profile on the proanthocyanin effect. Finally, GSPE could also reduce diet-induced hepatic oxidative stress not only by its ROS-scavenging properties but also by retraining the circadian rhythm of AOX enzymes.
C1 [Cortes-Espinar, Antonio J.; Ibarz-Blanch, Nestor; Soliz-Rueda, Jorge R.; Bravo, Francisca Isabel; Calvo, Enrique; Mulero, Miquel] Univ Rovira I Virgili, Dept Biochem & Biotechnol, Nutrigen Res Grp, Tarragona 43007, Spain.
   [Cortes-Espinar, Antonio J.; Ibarz-Blanch, Nestor; Soliz-Rueda, Jorge R.; Bravo, Francisca Isabel; Calvo, Enrique; Mulero, Miquel] Inst Invest Sanitaria Pere Virgili, Nutrigen Res Grp, Tarragona 43007, Spain.
   [Cortes-Espinar, Antonio J.; Bonafos, Beatrice; Feillet-Coudray, Christine; Casas, Francois] Univ Montpellier, DMEM, EMN, UMR 866,INRAe, F-34090 Montpellier, France.
   [Avila-Roman, Javier] Univ Seville, Dept Pharmacol, Mol & Appl Pharmacol Grp FARMOLAP, Seville 41012, Spain.
C3 Universitat Rovira i Virgili; Universitat Rovira i Virgili; Institut
   d'Investigacio Sanitaria Pere Virgili (IISPV); INRAE; Universite de
   Montpellier; University of Sevilla
RP Mulero, M (corresponding author), Univ Rovira I Virgili, Dept Biochem & Biotechnol, Nutrigen Res Grp, Tarragona 43007, Spain.; Mulero, M (corresponding author), Inst Invest Sanitaria Pere Virgili, Nutrigen Res Grp, Tarragona 43007, Spain.; Avila-Román, J (corresponding author), Univ Seville, Dept Pharmacol, Mol & Appl Pharmacol Grp FARMOLAP, Seville 41012, Spain.
EM antoniojesus.cortes@estudiants.urv.cat; nestor.ibarz@urv.cat;
   jorgericardo.soliz@fundacio.urv.cat; beatrice.bonafos@inrae.fr;
   christine.coudray@inrae.fr; rancois.casas@inrae.fr;
   franciscaisabel.bravo@urv.cat; enrique.calvo@urv.cat; avieravila@us.es;
   miquel.mulero@urv.cat
RI Bravo, Francisca/L-4409-2019; Avila-Roman, Javier/B-5337-2017; Ibarz
   Blanch, Néstor/HZK-7802-2023; COUDRAY, Charles/AGG-4757-2022; Mulero,
   Miquel/L-4672-2014; Calvo, Enrique/K-8680-2014; Soliz Rueda, Jorge
   Ricardo/HKE-0954-2023
OI Mulero, Miquel/0000-0003-2545-2065; Calvo, Enrique/0000-0002-2468-0931;
   Avila-Roman, Francisco Javier/0000-0001-9766-8178; Cortes Espinar,
   Antonio Jesus/0000-0003-4058-4672; Coudray,
   Christine/0000-0001-8420-2811; Ibarz-Blanch, Nestor/0000-0003-2920-8502;
   Soliz Rueda, Jorge Ricardo/0000-0001-7307-8202; Francois,
   Casas/0000-0002-5535-8195; Bravo, Francisca Isabel/0000-0002-6468-3088
FU Spanish Ministry of Science and Innovation MCIN/AEI; ERDF "A way of
   making Europe" [PID2021-128813OB-I00]; Universitat Rovira i
   Virgili-Marti i Franques [2019PMF-PIPF-74]
FX & nbsp;This project was funded by the Spanish Ministry of Science and
   Innovation MCIN/AEI/10.13039/501100011033/, by ERDF "A way of making
   Europe" (Grant number: PID2021-128813OB-I00). A.J.C.-E. was the
   recipient of a grant for the hiring of predoctoral research staff from
   Universitat Rovira i Virgili-Marti i Franques (2019PMF-PIPF-74). F.I.B.
   and M.M. are Serra Hunter Fellows.
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NR 99
TC 4
Z9 4
U1 1
U2 6
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD AUG
PY 2023
VL 12
IS 8
AR 1606
DI 10.3390/antiox12081606
PG 29
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA Q4LL1
UT WOS:001057248800001
PM 37627601
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Svoboda, DS
   Kawaja, MD
AF Svoboda, Devon S.
   Kawaja, Michael D.
TI Changes in hepatic protein expression in spontaneously hypertensive rats
   suggest early stages of non-alcoholic fatty liver disease
SO JOURNAL OF PROTEOMICS
LA English
DT Article
DE QDPR; Sulfite oxidase; Haptoglobin; Oxidative stress; SHR; Proteomics;
   Liver
ID NITRIC-OXIDE SYNTHASE; OXIDATIVE STRESS; METABOLIC SYNDROME;
   BLOOD-PRESSURE; CARDIOVASCULAR-DISEASE; ANTIOXIDANT STATUS; STELLATE
   CELLS; TETRAHYDROBIOPTERIN; HEART; MITOCHONDRIA
AB Hypertension is a systemic disorder affecting numerous physiological processes throughout the body. As non-alcoholic fatty liver disorder (NAFLD) is a common comorbidity of hypertension in humans, we hypothesized that molecular hepatic physiology would be altered in a model of genetic hypertension. Despite the broad use of the spontaneously hypertensive rat (SHR) model, little is known regarding how hypertension influences hepatic function under basal conditions. In order to determine whether hypertension induces changes in the hepatic protein expression suggestive of early stages of NAFLD, we compared the whole tissue proteome of livers from SHR and Wistar Kyoto (WKY) 16 week old rats using 2DGE and MALDI-TOF MS. Fifteen proteins were identified that display different levels of expression between the SHR and WKY livers: 50% of proteins have mitochondrial or anti-oxidant functions while 20% are involved in lipid metabolism. Quininoid dihydropterin reductase, sulfite oxidase, and glutathione-S-transferase mu 1 were all identified as either undergoing a difference in post-translation modification or a difference in protein abundance in SHR compared to WKY livers. As oxidative stress is a well described component of both NAFLD and hypertension in SHR, the identification of novel changes in protein expression provides possible mechanisms connecting these two pathologies in humans. (C) 2011 Elsevier B.V. All rights reserved.
C1 [Kawaja, Michael D.] Queens Univ, Ctr Neurosci Studies, Kingston, ON K7L 3N6, Canada.
   [Svoboda, Devon S.; Kawaja, Michael D.] Queens Univ, Dept Anat & Cell Biol, Kingston, ON K7L 3N6, Canada.
C3 Queens University - Canada; Queens University - Canada
RP Kawaja, MD (corresponding author), Queens Univ, Ctr Neurosci Studies, Room 947,Botterell Hall, Kingston, ON K7L 3N6, Canada.
EM kawajam@post.queensu.ca
FU Heart and Stroke Foundation of Ontario [T 5716]
FX This work was funded by a grant from the Heart and Stroke Foundation of
   Ontario (T 5716; MDK).
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NR 77
TC 13
Z9 16
U1 0
U2 8
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1874-3919
EI 1876-7737
J9 J PROTEOMICS
JI J. Proteomics
PD MAR 16
PY 2012
VL 75
IS 6
BP 1752
EP 1763
DI 10.1016/j.jprot.2011.12.011
PG 12
WC Biochemical Research Methods
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 915PA
UT WOS:000302038700006
PM 22240297
DA 2025-06-11
ER

PT J
AU Bhattacharya, K
   Dey, R
   Sen, D
   Paul, N
   Basak, AK
   Purkait, MP
   Shukla, N
   Chaudhuri, GR
   Bhattacharya, A
   Maiti, R
   Adhikary, K
   Chatterjee, P
   Karak, P
   Syamal, AK
AF Bhattacharya, Koushik
   Dey, Rajen
   Sen, Debanjana
   Paul, Nimisha
   Basak, Asim Kumar
   Purkait, Mohuya Patra
   Shukla, Nandini
   Chaudhuri, Gargi Ray
   Bhattacharya, Aniruddha
   Maiti, Rajkumar
   Adhikary, Krishnendu
   Chatterjee, Prity
   Karak, Prithviraj
   Syamal, Alak Kumar
TI Polycystic ovary syndrome and its management: In view of oxidative
   stress
SO BIOMOLECULAR CONCEPTS
LA English
DT Review
DE polycystic ovarian syndrome; oxidative stress; obesity; insulin
   resistance; inflammation; antioxidants; medicinal plants
ID ALPHA-LIPOIC ACID; GRADE CHRONIC INFLAMMATION; INSULIN-RESISTANCE;
   REACTIVE OXYGEN; TNF-ALPHA; DIAGNOSTIC-CRITERIA; METABOLIC SYNDROME;
   SYNDROME PCOS; DOUBLE-BLIND; LEAN WOMEN
AB In the past two decades, oxidative stress (OS) has drawn a lot of interest due to the revelation that individuals with many persistent disorders including diabetes, polycystic ovarian syndrome (PCOS), cardiovascular, and other disorders often have aberrant oxidation statuses. OS has a close interplay with PCOS features such as insulin resistance, hyperandrogenism, and chronic inflammation; there is a belief that OS might contribute to the development of PCOS. PCOS is currently recognized as not only one of the most prevalent endocrine disorders but also a significant contributor to female infertility, affecting a considerable proportion of women globally. Therefore, the understanding of the relationship between OS and PCOS is crucial to the development of therapeutic and preventive strategies for PCOS. Moreover, the mechanistic study of intracellular reactive oxygen species/reactive nitrogen species formation and its possible interaction with women's reproductive health is required, which includes complex enzymatic and non-enzymatic antioxidant systems. Apart from that, our current review includes possible regulation of the pathogenesis of OS. A change in lifestyle, including physical activity, various supplements that boost antioxidant levels, particularly vitamins, and the usage of medicinal herbs, is thought to be the best way to combat this occurrence of OS and improve the pathophysiologic conditions associated with PCOS.
C1 [Bhattacharya, Koushik] Centurion Univ Technol & Management, Sch Paramed & Allied Hlth Sci, Khurda Rd, Bhubaneswar, Odisha, India.
   [Dey, Rajen] Swami Vivekananda Univ, Dept Med Lab Technol, Barakpur, W Bengal, India.
   [Sen, Debanjana; Syamal, Alak Kumar] Hooghly Mohsin Coll, Postgrad Dept Physiol, Chinsura, W Bengal, India.
   [Paul, Nimisha] Hitkarini Dent Coll & Hosp, Dept Gen Human Physiol & Biochem, Jabalpur, Madhya Pradesh, India.
   [Basak, Asim Kumar] Brainware Univ, Sch Allied Hlth Sci, Barasat, W Bengal, India.
   [Purkait, Mohuya Patra] Sonarpur Mahavidyalaya, Dept Zool, Kolkata, W Bengal, India.
   [Shukla, Nandini] Pt JNM Med Coll, Dept Anat, Raipur, Madhya Pradesh, India.
   [Chaudhuri, Gargi Ray] Nopany Inst Hlth Care Studies, Dept Physiotherapy, Kolkata, W Bengal, India.
   [Bhattacharya, Aniruddha] Int Med Sch Management & Sci Univ, Dept Physiol, Selangor, Malaysia.
   [Maiti, Rajkumar; Karak, Prithviraj] Bankura Christian Coll, Dept Physiol, Bankura, W Bengal, India.
   [Adhikary, Krishnendu] Centurion Univ Technol & Management, Dept Interdisciplinary Sci, Khurda Rd, Bhubaneswar, Odisha, India.
   [Chatterjee, Prity] Paramed Coll, Dept Biotechnol, Durgapur, W Bengal, India.
C3 Centurion University of Technology & Management; Management Science
   University; Centurion University of Technology & Management
RP Bhattacharya, K (corresponding author), Centurion Univ Technol & Management, Sch Paramed & Allied Hlth Sci, Khurda Rd, Bhubaneswar, Odisha, India.
EM koushik22.2009@rediffmail.com
RI Dey, Rajen/KFB-5183-2024; Maiti, Dr. Rajkumar/KUF-2506-2024; Basak,
   Asim/MXK-8873-2025; Bhattacharya, Dr. Koushik/AAX-3145-2020
OI ADHIKARY, KRISHNENDU/0000-0002-9942-1491; Bhattacharya, Dr.
   Koushik/0000-0003-0153-4357; Dey, Rajen/0009-0009-2264-8047
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Z9 10
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PI BERLIN
PA GENTHINER STRASSE 13, D-10785 BERLIN, GERMANY
SN 1868-5021
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J9 BIOMOL CONCEPTS
JI BioMol. Concepts
PD JAN 19
PY 2024
VL 15
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AR 20220038
DI 10.1515/bmc-2022-0038
PG 21
WC Biochemistry & Molecular Biology
WE Emerging Sources Citation Index (ESCI)
SC Biochemistry & Molecular Biology
GA M9D6D
UT WOS:001360467100001
PM 38242137
OA gold
DA 2025-06-11
ER

PT J
AU Dias, DD
   Bernardes, N
   Stoyell-Conti, FF
   dos Santos, CP
   de Araujo, AA
   Llesuy, S
   Ingoyen, MC
   De Angelis, K
AF Dias, Danielle da Silva
   Bernardes, Nathalia
   Stoyell-Conti, Filipe Fernandes
   dos Santos, Camila Paixao
   de Araujo, Amanda Aparecida
   Llesuy, Susana
   Ingoyen, Maria Claudia
   De Angelis, Katie
TI Impact of combined exercise training on the development of
   cardiometabolic and neuroimmune complications induced by fructose
   consumption in hypertensive rats
SO PLOS ONE
LA English
DT Article
ID OXIDATIVE STRESS; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   BLOOD-PRESSURE; GLUTATHIONE; DYSFUNCTION; MECHANISMS; BEVERAGES; LIVER;
   MODEL
AB This study evaluated the impact of combined exercise training on the development of cardiovascular and neuroimmune complications induced by fructose consumption (10% in the drinking water) in hypertensive rats (SHR). After weaning, SHR were divided into 3 groups: SHR (H), SHR+fructose (HF) and SHR+fructose+combined exercise training (treadmill+ladder, 40-60% of maximum capacity) (HFTC). Metabolic, hemodynamic, autonomic, inflammatory and oxidative stress parameters were evaluated in the subgroups (n = 6 group/time) at 7, 15, 30 and 60 days of protocol. Fructose consumption (H vs. HF groups) decreased spontaneous baroreflex sensitivity and total variance of pulse interval at day 7 (7 to 60); increased IL-6 and TNF alpha in the heart (at day 15, 30 and 60) and NADPH oxidase activity and cardiac lipoperoxidation (LPO) (day 60); increased white adipose tissue weight, reduced insulin sensitivity and increased triglycerides (day 60); induced an additional increase in mean arterial pressure (MAP) (days 30 and 60). Combined exercise training prevented such dysfunctions and sustained increased cardiac IL-10 (day 7) and glutathione redox balance (GSH/GSSG) for the entire protocol. In conclusion, combined exercise training performed simultaneously with exacerbated fructose consumption prevented early cardiovascular autonomic dysfunction, probably trigging positive changes in inflammation and oxidative stress, resulting in a better cardiometabolic profile in rats genetically predisposed to hypertension.
C1 [Dias, Danielle da Silva; Bernardes, Nathalia; Llesuy, Susana; De Angelis, Katie] Univ Nove Julho UNINOVE, Lab Translat Physiol, Sao Paulo, SP, Brazil.
   [Dias, Danielle da Silva; dos Santos, Camila Paixao; de Araujo, Amanda Aparecida; De Angelis, Katie] Fed Univ Sao Paulo UNIFESP, Dept Physiol, Sao Paulo, SP, Brazil.
   [Stoyell-Conti, Filipe Fernandes] Univ Miami, Dept Surg, Miami, FL USA.
   [Llesuy, Susana] Hosp Italiano Buenos Aires, Inst Univ Hosp Italiano, Buenos Aires, DF, Argentina.
   [Ingoyen, Maria Claudia] Univ Sao Paulo, Sch Med, Heart Inst InCor, Hypertens Unit, Sao Paulo, SP, Brazil.
C3 Universidade Nove de Julho; Universidade Federal de Sao Paulo (UNIFESP);
   University of Miami; University of Buenos Aires; University of Buenos
   Aires Hospital; Hospital Italiano de Buenos Aires; Universidade de Sao
   Paulo
RP De Angelis, K (corresponding author), Univ Nove Julho UNINOVE, Lab Translat Physiol, Sao Paulo, SP, Brazil.; De Angelis, K (corresponding author), Fed Univ Sao Paulo UNIFESP, Dept Physiol, Sao Paulo, SP, Brazil.
EM prof.kangelis@yahoo.com.br
RI Bernardes, Nathalia/L-7460-2015; da Silva Dias, Danielle/AAN-7618-2020;
   Irigoyen, maria Claudia/N-6880-2014
OI Irigoyen, maria Claudia/0000-0003-2097-3662
FU CNPq [457200/2014-6, 309292/2014-0]; Fundacao de Amparo a Pesquisa do
   Estado de Sao Paulo (FAPESP) [2020/07482-4, 2015/11223-6]; CAPES
   [88881.062178/2014-01]; CNPq Fellowship (CNPq-BPQ) [5/29, SFDC 06651800]
FX This study was supported by CNPq (457200/2014-6; 309292/2014-0) and
   Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
   (2020/07482-4; 2015/11223-6); CAPES (88881.062178/2014-01). Katia De
   Angelis and Maria-Claudia Irigoyen are recipients of CNPq Fellowship
   (CNPq-BPQ)"(GJ, 5/29, SFDC 06651800).
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   2014, REG ANESTH PAIN MED, V9
NR 42
TC 6
Z9 6
U1 0
U2 2
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JUN 10
PY 2020
VL 15
IS 6
AR e0233785
DI 10.1371/journal.pone.0233785
PG 17
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA MC0EC
UT WOS:000542969500008
PM 32521542
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Francisqueti, FV
   Ferron, AJT
   Hasimoto, FK
   Alves, PHR
   Garcia, JL
   dos Santos, KC
   Moreto, F
   Silva, VD
   Ferreira, ALA
   Minatel, IO
   Corrêa, CR
AF Francisqueti, Fabiane Valentini
   Togneri Ferron, Artur Junio
   Hasimoto, Fabiana Kurokawa
   Rizzi Alves, Pedro Henrique
   Garcia, Jessica Leite
   dos Santos, Klinsmann Carolo
   Moreto, Fernando
   Silva, Vanessa dos Santos
   Ferreira, Ana Lucia A.
   Minatel, Igor Otavio
   Correa, Camila Renata
TI Gamma Oryzanol Treats Obesity-Induced Kidney Injuries by Modulating the
   Adiponectin Receptor 2/PPAR-α Axis
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Article
ID PPAR-ALPHA AGONIST; RICE BRAN OIL; OXIDATIVE STRESS; FERULIC ACID;
   DISEASE; FENOFIBRATE; MECHANISMS; PRODUCT; MICE
AB The kidney is an important organ in the maintenance of body homeostasis. Dietary compounds, reactive metabolites, obesity, and metabolic syndrome (MetS) can affect renal filtration and whole body homeostasis, increasing the risk of chronic kidney disease (CKD) development. Gamma oryzanol (gamma Oz) is a compound with antioxidant and anti-inflammatory activity that has shown a positive action in the treatment of obesity and metabolic diseases. Aim. To evaluate the effect of gamma Oz to recover renal function in obese animals by high sugar-fat diet by modulation of adiponectin receptor 2/PPAR-alpha axis Methods. Male Wistar rats were initially randomly divided into 2 experimental groups: control and high sugar-fat diet (HSF) for 20 weeks. When proteinuria was detected, HSF animals were allocated to receive gamma Oz or maintain HSF for more than 10 weeks. The following were analyzed: nutritional and biochemical parameters, systolic blood pressure, and renal function. In the kidney, the following were evaluated: inflammation, oxidative stress, and protein expression by Western blot. Results. After 10 weeks of gamma Oz treatment, gamma Oz was effective to improve inflammation, increase antioxidant enzyme activities, increase the protein expression of adiponectin receptor 2 and PPAR-alpha, and recover renal function. Conclusion. These results permit us to confirm that gamma Oz is able to modulate PPAR-alpha expression, inflammation, and oxidative stress pathways improving obesity-induced renal disease.
C1 [Francisqueti, Fabiane Valentini; Togneri Ferron, Artur Junio; Garcia, Jessica Leite; dos Santos, Klinsmann Carolo; Moreto, Fernando; Silva, Vanessa dos Santos; Ferreira, Ana Lucia A.; Correa, Camila Renata] Sao Paulo State Univ UNESP, Med Sch, Botucatu, SP, Brazil.
   [Hasimoto, Fabiana Kurokawa; Rizzi Alves, Pedro Henrique; Minatel, Igor Otavio] Sao Paulo State Univ UNESP, Inst Biosci, Botucatu, SP, Brazil.
C3 Universidade Estadual Paulista; Universidade Estadual Paulista
RP Francisqueti, FV (corresponding author), Sao Paulo State Univ UNESP, Med Sch, Botucatu, SP, Brazil.
EM fabiane_vf@yahoo.com.br
RI dos Santos, Klinsmann/O-2088-2014; Minatel, Igor/A-9094-2016;
   Francisqueti, Fabiane/AAY-8977-2020; Correa, Camila/Q-2071-2019; Silva,
   Vanessa/JXX-4985-2024; Francisqueti- Ferron, Fabiane/M-4919-2017; Leite
   Garcia, Jessica/Q-8779-2018; Moreto, Fernando/I-7690-2013; Ferron, Artur
   Junio/M-5194-2017
OI Francisqueti- Ferron, Fabiane/0000-0003-2910-4308; Correa, Camila
   Renata/0000-0001-8493-5329; Leite Garcia, Jessica/0000-0002-3670-243X;
   Moreto, Fernando/0000-0002-4028-0014; Ferron, Artur
   Junio/0000-0001-7089-3033
FU Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
   [2015/10626-0, 2018/15288-3]
FX This work was supported by Fundacao de Amparo a Pesquisa do Estado de
   Sao Paulo (FAPESP) (2015/10626-0 and 2018/15288-3).
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NR 35
TC 17
Z9 17
U1 1
U2 6
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PY 2018
VL 2018
AR 1278392
DI 10.1155/2018/1278392
PG 9
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA GU8EZ
UT WOS:000445570600001
PM 30271526
OA Green Published, Green Submitted, hybrid
DA 2025-06-11
ER

PT J
AU Rosas-Villegas, A
   Sánchez-Tapia, M
   Avila-Nava, A
   Ramírez, V
   Tovar, AR
   Torres, N
AF Rosas-Villegas, Adriana
   Sanchez-Tapia, Monica
   Avila-Nava, Azalia
   Ramirez, Victoria
   Tovar, Armando R.
   Torres, Nimbe
TI Differential Effect of Sucrose and Fructose in Combination with a High
   Fat Diet on Intestinal Microbiota and Kidney Oxidative Stress
SO NUTRIENTS
LA English
DT Article
DE microbiota; renal oxidative stress; sucrose; fructose; obesity; LPS;
   inflammation
ID INSULIN-RESISTANCE; METABOLIC SYNDROME; LACTOBACILLUS-REUTERI;
   LIVER-DISEASE; OBESITY; INFLAMMATION; BIOMARKER; MICE; TOLL
AB There is controversial information about the adverse effect of sucrose (S) or fructose (F) in the development of obesity. Thus, the purpose of the study was to evaluate the effect of S or F in a high fat diet (HF) on gut microbiota and renal oxidative stress. Rats were fed for four months with either high-fat + sucrose (HFS) or high-fat + fructose (HFF) or a control diet (C). Half of the HFS or HFF groups were maintained with the same diet and the other half were switched to the consumption of C. HFS and HFF groups increased 51% and 19% body weight, respectively, compared with the C group. Body fat mass, metabolic inflexibility, glucose intolerance, lipopolysaccharide (LPS), insulin, renal reactive oxygen species (ROS), malondialdehyde (MDA), Nadphox, and Srebp-1 were significantly higher and antioxidant enzymes and lean body mass were significantly lower in the HFS group with respect to the HF-F group. Change in the consumption of HFS or HFF to a C diet ameliorated the insulin and glucose intolerance. The type of carbohydrate differentially modified the microbiota composition, however, both groups significantly decreased C. eutactus with respect to the C group. Thus, metabolic alterations with the HFS diet had a more detrimental effect than HFF.
C1 [Rosas-Villegas, Adriana; Sanchez-Tapia, Monica; Avila-Nava, Azalia; Tovar, Armando R.; Torres, Nimbe] Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Fisiol Nutr, Mexico City 14080, DF, Mexico.
   [Ramirez, Victoria] Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Nefrol, Mexico City 14080, DF, Mexico.
C3 Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran -
   Mexico; Instituto Nacional de Ciencias Medicas y Nutricion Salvador
   Zubiran - Mexico
RP Torres, N (corresponding author), Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Fisiol Nutr, Mexico City 14080, DF, Mexico.
EM kadriana.rosas@gmail.com; qfbmoniktc@gmail.com; zomi33@gmail.com;
   vikka60@hotmail.com; tovar.ar@gmail.com; nimbester@gmail.com
RI SANCHEZ-TAPIA, MONICA/JDV-7490-2023; Torres, Nimbe/AAI-4340-2020;
   Ramirez Gonzalez, Victoria/I-8087-2012
OI Rosas-Villegas, Adriana/0000-0001-9114-0882; Sanchez-Tapia,
   Monica/0000-0001-9748-5734; Ramirez Gonzalez,
   Victoria/0000-0002-2782-1381; Avila-Nava, Azalia/0000-0003-3363-1477
FU Consejo Nacional de Ciencia y Tecnologia (CONACYT) [257339]; Instituto
   Danone de Mexico; Academy of Finland (AKA) [257339] Funding Source:
   Academy of Finland (AKA)
FX This study was supported by a financial grant from Consejo Nacional de
   Ciencia y Tecnologia (CONACYT) No. 257339 (to N.T.). M.S.T. received a
   fellowship from Instituto Danone de Mexico.
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NR 37
TC 64
Z9 67
U1 0
U2 22
PU MDPI AG
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 2072-6643
J9 NUTRIENTS
JI Nutrients
PD APR
PY 2017
VL 9
IS 4
AR 393
DI 10.3390/nu9040393
PG 13
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA EU9JI
UT WOS:000401355600078
PM 28420148
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Heyman, A
   Edwards, L
   Lavalle, JB
   Swidan, S
AF Heyman, Andrew
   Edwards, Lena
   Lavalle, James B.
   Swidan, Sahar
TI Cardiometabolic disease in men: an integrative medicine approach to
   managing hormonal risk factors
SO JOURNAL OF MENS HEALTH
LA English
DT Article
DE Cardiometabolic disease; Hormonal risk factors; Integrative medicine
ID ALPHA-LIPOIC ACID; SALIVARY CORTISOL; DIABETES-MELLITUS; ADIPOSE-TISSUE;
   TESTOSTERONE DEFICIENCY; ANDROGEN DEFICIENCY; CHRONIC STRESS;
   DOUBLE-BLIND; INSULIN; GLUCOSE
AB This article reviews the known pathophysiology of cardiometabolic disease (CM) and discusses methods of diagnosis and evaluation of male patients who may be at risk for CM disease. The usefulness of integrative medicine treatment is also reviewed.
   These topics are illustrated by means of an actual case of a 55 year-old Caucasian male with no significant past medical history who presented to an integrative medicine clinic complaining of generalized fatigue and weight gain of 30 pounds during the preceding 4 years. After a comprehensive work-up, the patient was diagnosed with metabolic syndrome and advised to begin an exercise program, improve his diet, and lose weight.
   The patient was prescribed various supplements in addition to testosterone replacement. He was also advised on stress management techniques.
   After 3 months, the patient had successfully lost 25 pounds through dietary modifications, recommended dietary supplements, and exercise. He reported less daytime fatigue, particularly after meals, and improved sleep at night. His stress levels remained unchanged but he felt 'more even' and less susceptible to stressful events on the l-theanine. He had no adverse side effects from the medications or supplements and PSA levels remained unchanged. He was scheduled to return to the clinic in 3 months for re-evaluation. (C) 2010 WPMH GmbH. Published by Elsevier Ireland Ltd.
C1 [Heyman, Andrew] Univ Michigan, Sch Med, Dept Family Med, Ann Arbor, MI 48109 USA.
   [Edwards, Lena] Balance Hlth & Wellness Ctr, Lexington, KY USA.
   [Lavalle, James B.] Univ Cincinnati, Coll Pharm, Cincinnati, OH 45267 USA.
   [Swidan, Sahar] Univ Michigan, Coll Pharm, Ann Arbor, MI 48109 USA.
C3 University of Michigan System; University of Michigan; University System
   of Ohio; University of Cincinnati; University of Michigan System;
   University of Michigan
RP Heyman, A (corresponding author), Univ Michigan, Sch Med, Dept Family Med, Ann Arbor, MI 48109 USA.
EM ahheyman@med.umich.edu
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NR 62
TC 0
Z9 0
U1 0
U2 6
PU CODON PUBLICATIONS
PI BRISBANE
PA LEVEL 9, 167 EAGLE ST, BRISBANE, QLD 4000, AUSTRALIA
SN 1875-6867
EI 1875-6859
J9 J MENS HEALTH
JI J. Mens Health
PD MAR
PY 2010
VL 7
IS 1
BP 92
EP 101
DI 10.1016/j.jomh.2009.11.002
PG 10
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA 687WN
UT WOS:000284809000011
DA 2025-06-11
ER

PT J
AU Mo, L
   Li, JJ
   Lu, HS
   Lu, SD
   Fu, HH
   Huang, B
   Zhao, CC
AF Mo, Ling
   Li, Jingjing
   Lu, Hangsun
   Lu, Shaoda
   Fu, Henghui
   Huang, Bo
   Zhao, Chaochao
TI Aloe polysaccharides ameliorate obesity-associated cognitive dysfunction
   in high-fat diet-fed mice by targeting the gut microbiota and intestinal
   barrier integrity
SO FOOD & FUNCTION
LA English
DT Article
ID METABOLIC SYNDROME; IMPAIRMENT; MEMORY; INFLAMMATION; DISEASE; IMPACT
AB Aloe polysaccharides (APs) display cognition-improving properties, but the underlying mechanisms remain unclear. Herein, AP supplementation for 24 weeks significantly improved cognitive behavioral disturbances caused by a high-fat diet. Moreover, APs notably reshaped the structure of the gut microbiota, which was manifested by increasing the relative abundance of Alloprevotella, Alistipes, Romboutsia, Turicibacter, Prevotellaceae_UCG-001, and Akkermansia while reducing the abundance of Parasutterella, Staphylococcus, Helicobacter, Enterococcus, and Erysipelatoclostridium. Notably, the gut barrier damage and LPS leakage caused by HF were recovered by APs. Additionally, with the improvement of intestinal barrier integrity, oxidative stress and inflammation in the brain and jejunum were significantly ameliorated. Furthermore, the expression of genes associated with cognitive impairment and the intestinal tract barrier was up-regulated (CREB, BDNF, TrkB, ZO-1 and occludin), while the expression of genes associated with inflammatory factors was down-regulated (IL-1 beta, IL-6, and TNF-alpha). Finally, we observed a significant correlation among cognition-related genes, gut microbiota, oxidative stress, and inflammation in the HF-AP group. Together, our findings suggest that altered gut microbiota composition and improved gut barrier integrity may be important targets for potentially improving high-fat diet-induced cognitive impairment.
   Aloe polysaccharides improve cognitive impairment in HF diet-induced mice, related to remodeling of the intestinal microbiota and changes in the intestinal barrier, in addition to improving inflammation and oxidative stress in the gut and brain.
C1 [Mo, Ling; Li, Jingjing; Huang, Bo; Zhao, Chaochao] Guilin Med Univ, Sch Publ Hlth, Guangxi Key Lab Environm Expos & Entire Lifecycle, Guilin 541199, Peoples R China.
   [Mo, Ling; Li, Jingjing; Lu, Hangsun; Lu, Shaoda; Fu, Henghui] Guilin Med Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Guilin 541199, Peoples R China.
C3 Guilin Medical University; Guilin Medical University
RP Huang, B; Zhao, CC (corresponding author), Guilin Med Univ, Sch Publ Hlth, Guangxi Key Lab Environm Expos & Entire Lifecycle, Guilin 541199, Peoples R China.
EM 2559341252@QQ.com; zhaocc130718@163.com
OI Mo, Ling/0000-0003-4452-4757
FU National Natural Science Foundation of Guangxi [2021GXNSFBA075038];
   Guangxi Young and Middle-aged Teachers Basic Ability Improvement Project
   [2019KY0547, 2021KY0511]; Guangxi Key Laboratory of Environmental
   Exposomics and Entire Lifecycle Health; School of Public Health at
   Guilin Medical University
FX This research was supported by the National Natural Science Foundation
   of Guangxi (NO 2021GXNSFBA075038) and the Guangxi Young and Middle-aged
   Teachers Basic Ability Improvement Project (NO 2019KY0547 and NO
   2021KY0511). This study was carried out with the laboratory support of
   the Guangxi Key Laboratory of Environmental Exposomics and Entire
   Lifecycle Health and the School of Public Health at Guilin Medical
   University.
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NR 56
TC 3
Z9 3
U1 21
U2 83
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PD JUL 29
PY 2024
VL 15
IS 15
BP 8070
EP 8086
DI 10.1039/d4fo01844c
EA JUL 2024
PG 17
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA ZY7W2
UT WOS:001266204700001
PM 38989726
DA 2025-06-11
ER

PT J
AU Malínská, H
   Hüttl, M
   Marková, I
   Miklánková, D
   Hojná, S
   Papousek, F
   Silhavy, J
   Mlejnek, P
   Zicha, J
   Hrdlicka, J
   Pravenec, M
   Vanecková, I
AF Malinska, Hana
   Huttl, Martina
   Markova, Irena
   Miklankova, Denisa
   Hojna, Silvie
   Papousek, Frantisek
   Silhavy, Jan
   Mlejnek, Petr
   Zicha, Josef
   Hrdlicka, Jaroslav
   Pravenec, Michal
   Vaneckova, Ivana
TI Beneficial Effects of Empagliflozin Are Mediated by Reduced Renal
   Inflammation and Oxidative Stress in Spontaneously Hypertensive Rats
   Expressing Human C-Reactive Protein
SO BIOMEDICINES
LA English
DT Article
DE SHR-CRP; SGLT-2 inhibitor; gene expression; age; lipid metabolism
ID LIPID-METABOLISM; INHIBITOR EMPAGLIFLOZIN; CARDIOVASCULAR OUTCOMES;
   DIABETIC-NEPHROPATHY; KIDNEY-DISEASE; ACCUMULATION; ACID; MICE;
   GLOMERULOSCLEROSIS; ACTIVATION
AB Gliflozins (inhibitors of sodium-glucose cotransporter 2) show many beneficial actions beyond their antidiabetic effects. The underlying mechanisms of these additional protective effects are still not well understood, especially under non-diabetic conditions. Therefore, we analyzed the effects of empagliflozin in young (3-month-old) and adult (12-month-old) male spontaneously hypertensive rats (SHR) expressing human C-reactive protein (CRP) in the liver. SHR-CRP rats are a non-diabetic model of metabolic syndrome, inflammation, and organ damage. Empagliflozin was given in a daily dose of 10 mg/kg body weight for 8 weeks. Both age groups of SHR-CRP rats treated with empagliflozin had lower body weight, decreased weight of fat depots, reduced ectopic fat accumulation in the liver and kidneys, and decreased levels of plasma insulin and beta-hydroxybutyrate. Empagliflozin effectively reduced ectopic renal fat accumulation, and was associated with decreased inflammation. Exclusively in young rats, decreased microalbuminuria after empagliflozin treatment was accompanied by attenuated oxidative stress. In adult animals, empagliflozin also improved left ventricle function. In conclusion, in young animals, the beneficial renoprotective effects of empagliflozin could be ascribed to reduced lipid deposition in the kidney and the attenuation of oxidative stress and inflammation. In contrast, hepatic lipid metabolism was ameliorated in adult rats.
C1 [Malinska, Hana; Huttl, Martina; Markova, Irena; Miklankova, Denisa] Inst Clin & Expt Med, Prague 14220, Czech Republic.
   [Hojna, Silvie; Papousek, Frantisek; Silhavy, Jan; Mlejnek, Petr; Zicha, Josef; Hrdlicka, Jaroslav; Pravenec, Michal; Vaneckova, Ivana] Czech Acad Sci, Inst Physiol, Prague 14220, Czech Republic.
C3 Institute for Clinical & Experimental Medicine (IKEM); Czech Academy of
   Sciences; Institute of Physiology of the Czech Academy of Sciences
RP Vanecková, I (corresponding author), Czech Acad Sci, Inst Physiol, Prague 14220, Czech Republic.
EM ivana.vaneckova@fgu.cas.cz
RI Mlejnek, Petr/C-2305-2012; Hrdlicka, Jaroslav/GXW-1534-2022; Hojna,
   Silvie/B-7985-2012; Vaneckova, Ivana/B-5543-2012; Silhavy,
   Jan/B-5292-2014; Zicha, Josef/B-1349-2012; Pravenec, Michal/B-1666-2012
OI Pravenec, Michal/0000-0001-9197-5871; Vaneckova,
   Ivana/0000-0002-1852-924X; Hojna, Silvie/0000-0002-2487-7283; Malinska,
   Hana/0000-0002-9076-3399; Huttl, Martina/0000-0002-2484-3630; Markova,
   Irena/0000-0002-4331-7636
FU Czech Science Foundation [19-06199S]; Ministry of Health of the Czech
   Republic-conceptual development of research organisations (Institute for
   Clinical and Experimental Medicine-IKEM) [IN 00023001]; project National
   Institute for Research of Metabolic and Cardiovascular Diseases
   (Programme EXCELES) - European Union-Next Generation EU [LX22NPO5104];
   Institute of Physiology, Czech Academy of Sciences [RVO 67985823]
FX This work was supported by grant of Czech Science Foundation, project
   number 19-06199S and the Ministry of Health of the Czech
   Republic-conceptual development of research organisations (Institute for
   Clinical and Experimental Medicine-IKEM, IN 00023001) and by the project
   National Institute for Research of Metabolic and Cardiovascular Diseases
   (Programme EXCELES, ID Project No. LX22NPO5104)-Funded by the European
   Union-Next Generation EU. This study was also supported by institutional
   support of the Institute of Physiology, Czech Academy of Sciences, grant
   Nr. RVO 67985823.
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NR 46
TC 13
Z9 14
U1 0
U2 6
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2227-9059
J9 BIOMEDICINES
JI Biomedicines
PD SEP
PY 2022
VL 10
IS 9
AR 2066
DI 10.3390/biomedicines10092066
PG 15
WC Biochemistry & Molecular Biology; Medicine, Research & Experimental;
   Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Research & Experimental Medicine;
   Pharmacology & Pharmacy
GA 4V3PA
UT WOS:000859391100001
PM 36140169
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Ruiz-Castell, M
   Le Coroller, G
   Landrier, JF
   Kerkour, D
   Weber, B
   Fagherazzi, G
   Appenzeller, BMR
   Vaillant, M
   Bohn, T
AF Ruiz-Castell, Maria
   Le Coroller, Gwenaelle
   Landrier, Jean-Francois
   Kerkour, Djedgiga
   Weber, Bernard
   Fagherazzi, Guy
   Appenzeller, Brice M. R.
   Vaillant, Michel
   Bohn, Torsten
TI Micronutrients and Markers of Oxidative Stress and Inflammation Related
   to Cardiometabolic Health: Results from the EHES-LUX Study
SO NUTRIENTS
LA English
DT Article
DE population based study; antioxidants; adipokines; cardio metabolic
   health; secondary plant compounds
AB Metabolic syndrome (MetS) characteristics include chronic inflammation and elevated oxidative stress. This study assessed associations between circulating concentrations of micronutrients/phytochemicals and inflammatory/oxidative stress markers with MetS and MetS components. Adults (N = 606) from the European Health Examination Survey in Luxembourg (2013-2015) were randomly selected. We performed a multivariable logistic regression model using the least absolute shrinkage and selection operator to identify MetS-associated variables. Participants with MetS had higher concentrations of C-reactive protein (CRP), 8-iso-prostaglandin F2 alpha, leptin, insulin, and vitamins E/A, but lower concentrations of adiponectin, beta-carotene, and oxidized low-density lipoprotein. A one-unit increase in log-CRP was associated with 51% greater odds of MetS (OR = 1.51 (95% CI: 1.16, 1.98)). Adults with a one-unit increase in log-leptin were 3.1 times more likely to have MetS (3.10 (2.10, 4.72)). Women with a one-unit increase in vitamin A were associated with 3% increased odds of MetS (1.03 (1.01, 1.05)), while those with a one-unit increase in log-adiponectin were associated with 82% decreased odds (0.18 (0.07, 0.46)). Chronic inflammation best characterized adults with MetS, as CRP, adiponectin, and leptin were selected as the main MetS determinants. Micronutrients did not seem to affect MetS, except for vitamin A in women.
C1 [Ruiz-Castell, Maria; Kerkour, Djedgiga] Luxembourg Inst Hlth, Dept Populat Hlth, 1A-B Rue Thomas Edison, L-1445 Strassen, Luxembourg.
   [Le Coroller, Gwenaelle; Vaillant, Michel] Luxembourg Inst Hlth, Competence Ctr Methodol & Stat, Dept Populat Hlth, 1A-B Rue Thomas Edison, L-1445 Strassen, Luxembourg.
   [Landrier, Jean-Francois] Aix Marseille Univ, INSERM, C2VN, INRAE, F-13005 Marseille, France.
   [Weber, Bernard] Lab Reunis Luxembourg SA, 38 Rue Hiehl, L-6131 Junglinster, Luxembourg.
   [Fagherazzi, Guy] Luxembourg Inst Hlth, Deep Digital Phenotyping Res Unit, Dept Populat Hlth, 1A-B Rue Thomas Edison, L-1445 Strassen, Luxembourg.
   [Appenzeller, Brice M. R.] Luxembourg Inst Hlth, Human Biomonitoring Res Unit, Dept Populat Hlth, 1A-B Rue Thomas Edison, L-1445 Strassen, Luxembourg.
   [Bohn, Torsten] Luxembourg Inst Hlth, Nutr & Hlth Res Unit, Dept Populat Hlth, 1A-B Rue Thomas Edison, L-1445 Strassen, Luxembourg.
C3 Luxembourg Institute of Health; Luxembourg Institute of Health; INRAE;
   Institut National de la Sante et de la Recherche Medicale (Inserm);
   Aix-Marseille Universite; Luxembourg Institute of Health; Luxembourg
   Institute of Health; Luxembourg Institute of Health
RP Ruiz-Castell, M (corresponding author), Luxembourg Inst Hlth, Dept Populat Hlth, 1A-B Rue Thomas Edison, L-1445 Strassen, Luxembourg.
EM maria.ruiz@lih.lu; Gwenaelle.LeCoroller@lih.lu;
   Jean-francois.LANDRIER@univ-amu.fr; djedjiga.kerkour@outlook.com;
   Bernard.Weber@labo.lu; Guy.Fagherazzi@lih.lu; Brice.Appenzeller@lih.lu;
   Michel.Vaillant@lih.lu; Torsten.Bohn@lih.lu
RI Bohn, Torsten/AAE-8393-2019; vaillant, michel/H-5635-2019; Bustamante,
   Mariona/ABB-9142-2021; Fagherazzi, Guy/P-3534-2017; Landrier,
   Jean-Francois/AAH-2757-2019
OI Appenzeller, Brice/0000-0001-9021-929X; Ruiz-Castell,
   Maria/0000-0001-9741-7491; Fagherazzi, Guy/0000-0001-5033-5966;
   vaillant, michel/0000-0003-4714-8128; Landrier,
   Jean-Francois/0000-0002-8690-8014; Bohn, Torsten/0000-0002-7825-0697
FU National Research Fund of Luxembourg [C17/BM/11653863/iMPACT.lu];
   Directorate and Ministry of Health; Ministry of Higher Education and
   Research (MESR)
FX This research was funded by the National Research Fund of Luxembourg
   (C17/BM/11653863/iMPACT.lu to MRC), the Directorate and Ministry of
   Health, and the Ministry of Higher Education and Research (MESR).
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NR 44
TC 13
Z9 13
U1 0
U2 1
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JAN
PY 2021
VL 13
IS 1
AR 5
DI 10.3390/nu13010005
PG 13
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA PW4GS
UT WOS:000610630200001
PM 33374992
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Jensen, BK
   Roth, LM
   Grinspan, JB
   Jordan-Sciutto, KL
AF Jensen, Brigid K.
   Roth, Lindsay M.
   Grinspan, Judith B.
   Jordan-Sciutto, Kelly L.
TI White matter loss and oligodendrocyte dysfunction in HIV: A consequence
   of the infection, the antiretroviral therapy or both?
SO BRAIN RESEARCH
LA English
DT Review
DE HIV; HAND; Oligodendrocytes; White matter; Myelin; Neuroinflammation
ID HUMAN-IMMUNODEFICIENCY-VIRUS; ENDOPLASMIC-RETICULUM STRESS; UNFOLDED
   PROTEIN RESPONSE; PELIZAEUS-MERZBACHER-DISEASE; OXIDATIVE STRESS;
   MULTIPLE-SCLEROSIS; NEUROCOGNITIVE DISORDER; INHIBITORS ACTIVATE;
   NEUROTROPHIC FACTOR; CORPUS-CALLOSUM
AB While the severe cognitive effects of HIV-associated dementia have been reduced by combined antiretroviral therapy (cART), nearly half of HIV-positive (HIV+) patients still suffer from some form of HIV-Associated Neurocognitive Disorders (HAND). While frank neuronal loss has been dramatically reduced in HAND patients, white matter loss, including dramatic thinning of the corpus callosum, and loss of volume and structural integrity of myelin persists despite viral control by cART. It remains unclear whether changes in white matter underlie the clinical manifestation seen in patients or whether they are the result of persistent viral reservoirs, remnant damage from the acute infection, the antiretroviral compounds used to treat HIV, secondary effects due to peripheral toxicities or other associated comorbid conditions. Both HIV infection itself and its treatment with antiretroviral drugs can induce metabolic syndrome, lipodystrophy, atherosclerosis and peripheral neuropathies by increased oxidative stress, induction of the unfolded protein response and dysregulation of lipid metabolism. These virally and/or cART-induced processes can also cause myelin loss in the CNS. This review aims to highlight existing data on the contribution of white matter damage to HAND and explore the mechanisms by which HIV infection and its treatment contribute to persistence of white matter changes in people living with HIV currently on cART.
C1 [Jensen, Brigid K.] Thomas Jefferson Univ, Jefferson Weinberg ALS Ctr, Vickie & Jack Farber Inst Neurosci, Philadelphia, PA 19107 USA.
   [Jensen, Brigid K.; Roth, Lindsay M.; Jordan-Sciutto, Kelly L.] Childrens Hosp Philadelphia, Dept Neurol, Philadelphia, PA 19104 USA.
   [Jensen, Brigid K.; Roth, Lindsay M.; Grinspan, Judith B.] Univ Penn, Sch Dent Med, Dept Pathol, Room 312,Levy Bldg,240 S 40th St, Philadelphia, PA 19104 USA.
C3 Thomas Jefferson University; University of Pennsylvania; Pennsylvania
   Medicine; Childrens Hospital of Philadelphia; University of Pennsylvania
RP Jordan-Sciutto, KL (corresponding author), Univ Penn, Sch Dent Med, Dept Pathol, Room 312,Levy Bldg,240 S 40th St, Philadelphia, PA 19104 USA.
EM jordank@upenn.edu
RI Grinspan, Judith/HJP-0589-2023
OI Jensen, Brigid/0000-0003-1624-6307; Roth, Lindsay/0000-0001-6452-3386
FU National Multiple Sclerosis Society [RG1506-04717]; NIH [F31 NS079192,
   T32 NS007180];  [RO1 MH098742];  [R21 MH118121]
FX This project was supported by the following grants: RO1 MH098742 (KJS
   and JBG), R21 MH118121 (KJS and JBG National Multiple Sclerosis Society
   RG1506-04717 (JBG), NIH F31 NS079192 (BKJ) NIH T32 NS007180 (BKJ), and
   T32 NS007180 (LMR).
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NR 139
TC 29
Z9 36
U1 0
U2 9
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0006-8993
EI 1872-6240
J9 BRAIN RES
JI Brain Res.
PD DEC 1
PY 2019
VL 1724
AR 146397
DI 10.1016/j.brainres.2019.146397
PG 9
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA JF8PO
UT WOS:000491646600025
PM 31442414
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Santos, JDB
   Mendonça, AAS
   Sousa, RC
   Silva, TGS
   Bigonha, SM
   Santos, EC
   Gonçalves, RV
   Novaes, RD
AF Santos, Jamili D. B.
   Mendonca, Andrea A. S.
   Sousa, Rafaela C.
   Silva, Thaiany G. S.
   Bigonha, Solange M.
   Santos, Eliziaria C.
   Goncalves, Reggiani V.
   Novaes, Romulo D.
TI Food-drug interaction: Anabolic steroids aggravate hepatic lipotoxicity
   and nonalcoholic fatty liver disease induced by trans fatty acids
SO FOOD AND CHEMICAL TOXICOLOGY
LA English
DT Article
DE Hepatotoxicity; Fat liver disease; Food-drug interaction; Oxidative
   stress; Steatosis
ID GENE-EXPRESSION PROFILES; DIET-INDUCED OBESITY; ANDROGENIC STEROIDS;
   METABOLIC SYNDROME; CARDIOVASCULAR-DISEASE; INDUCED HEPATOTOXICITY;
   ANTIOXIDANT ENZYMES; INSULIN-RESISTANCE; OXIDATIVE STRESS;
   LIPID-METABOLISM
AB Remains unknown if dietary lipids and anabolic steroids (AS) can interact to modify energy metabolism, hepatic structure and function. We investigated the impact of AS on gene expression, lipid profile, redox status and the development of nonalcoholic fatty liver disease (NAFLD) in mice treated with a diet rich in trans fatty acids. Seventy-two C57BL/6 mice were equally randomized into six groups and treated with a standard diet (SD) or high-fat diet (HFD) alone or combined with testosterone cypionate (10 or 20 mg/kg) for 12 weeks. When combined with a HFD, AS reduced plasma HDL cholesterol levels. It also upregulated SREBP-1, PPAR alpha, SCD-1 and ACOX1 gene expression; plasma and hepatic triglyceride levels; oxidative stress; circulating hepatic transaminase levels and NAFLD severity. Our finding indicated that the activity of antioxidant enzymes such as catalase, glutathione-s-transferase and superoxide dismutase was attenuated by HFD, an effect whose implications for AS-induced hepatotoxicity requires further investigation. Increased lipid, protein and DNA oxidative damage as well as worsening NAFLD in response to the interaction of HFD and AS were also potentially associated with the ability of AS to amplify the activation of regulatory lipid metabolism genes that are also involved in the control of cellular redox balance.
C1 [Santos, Jamili D. B.; Mendonca, Andrea A. S.; Sousa, Rafaela C.; Silva, Thaiany G. S.; Novaes, Romulo D.] Univ Fed Alfenas, Dept Struct Biol, Inst Biomed Sci, Rua Gabriel Monteiro da Silva 700, BR-37130000 Alfenas, MG, Brazil.
   [Bigonha, Solange M.] Univ Fed Vicosa, Dept Nutr & Hlth, BR-36570000 Vicosa, MG, Brazil.
   [Santos, Eliziaria C.] Fed Univ Jequitinhonha & Mucuri Valleys, Sch Med, BR-39100000 Diamantina, MG, Brazil.
   [Goncalves, Reggiani V.] Univ Fed Vicosa, Dept Anim Biol, BR-36570000 Vicosa, MG, Brazil.
C3 Universidade Federal de Alfenas; Universidade Federal de Vicosa;
   Universidade Federal dos Vales do Jequitinhonha e Mucuri (UFVJM);
   Universidade Federal de Vicosa
RP Novaes, RD (corresponding author), Univ Fed Alfenas, Dept Struct Biol, Inst Biomed Sci, Rua Gabriel Monteiro da Silva 700, BR-37130000 Alfenas, MG, Brazil.
EM romulo.novaes@unifal-mg.edu.br
RI Souza-Silva, Thaiany/A-6961-2019; Novaes, Romulo/F-1210-2015; Mendonca,
   Andrea/LCD-7208-2024; Goncalves, Reggiani/J-1550-2016; santos,
   Eliziaria/M-3107-2017
OI Goulart de Souza e Silva, Thaiany/0000-0002-1068-0156; Goncalves,
   Reggiani/0000-0002-5831-3590; santos, Eliziaria/0000-0003-0825-5836
FU Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq);
   Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES);
   Fundacao de Amparo a Pesquisa do Estado de Minas Gerais (FAPEMIG); CNPq
   [303972/2017-3]
FX This study was supported by the Brazilian agencies "Conselho Nacional de
   Desenvolvimento Cientifico e Tecnologico (CNPq)", "Coordenacao de
   Aperfeicoamento de Pessoal de Nivel Superior (CAPES)" and "Fundacao de
   Amparo a Pesquisa do Estado de Minas Gerais (FAPEMIG)". The author
   Romulo Dias Novaes thanks CNPq for the fellowship granted to the
   research in productivity (process 303972/2017-3). The funders had no
   role in study design, data collection and analysis, decision to publish,
   or preparation of the manuscript.
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NR 74
TC 28
Z9 30
U1 0
U2 17
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0278-6915
EI 1873-6351
J9 FOOD CHEM TOXICOL
JI Food Chem. Toxicol.
PD JUN
PY 2018
VL 116
BP 360
EP 368
DI 10.1016/j.fct.2018.04.056
PN B
PG 9
WC Food Science & Technology; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Toxicology
GA GH7TK
UT WOS:000433656100040
PM 29704577
DA 2025-06-11
ER

PT J
AU Khraishah, H
   Chen, Z
   Rajagopalan, S
AF Khraishah, Haitham
   Chen, Zhuo
   Rajagopalan, Sanjay
TI Understanding the Cardiovascular and Metabolic Health Effects of Air
   Pollution in the Context of Cumulative Exposomic Impacts
SO CIRCULATION RESEARCH
LA English
DT Review
DE air pollution; cardiometabolic; cardiovascular diseases; disparities;
   exposome; particulate matter
ID AIRBORNE PARTICULATE MATTER; SHORT-TERM EXPOSURE; MEASUREMENT ERROR;
   RISK-FACTORS; MORTALITY; ASSOCIATION; POPULATION; STRESS; VULNERABILITY;
   DISEASE
AB Poor air quality accounts for more than 9 million deaths a year globally according to recent estimates. A large portion of these deaths are attributable to cardiovascular causes, with evidence indicating that air pollution may also play an important role in the genesis of key cardiometabolic risk factors. Air pollution is not experienced in isolation but is part of a complex system, influenced by a host of other external environmental exposures, and interacting with intrinsic biologic factors and susceptibility to ultimately determine cardiovascular and metabolic outcomes. Given that the same fossil fuel emission sources that cause climate change also result in air pollution, there is a need for robust approaches that can not only limit climate change but also eliminate air pollution health effects, with an emphasis of protecting the most susceptible but also targeting interventions at the most vulnerable populations. In this review, we summarize the current state of epidemiologic and mechanistic evidence underpinning the association of air pollution with cardiometabolic disease and how complex interactions with other exposures and individual characteristics may modify these associations. We identify gaps in the current literature and suggest emerging approaches for policy makers to holistically approach cardiometabolic health risk and impact assessment.
C1 [Khraishah, Haitham] Univ Maryland, Med Ctr, Div Cardiovasc Med, Baltimore, MD USA.
   [Chen, Zhuo; Rajagopalan, Sanjay] Univ Hosp, Harrington Heart & Vasc Inst, Cleveland, OH 44106 USA.
   [Chen, Zhuo; Rajagopalan, Sanjay] Case Western Reserve Univ, Sch Med, Cleveland, OH USA.
C3 University System of Maryland; University of Maryland Baltimore;
   University Hospitals of Cleveland; University System of Ohio; Case
   Western Reserve University
RP Rajagopalan, S (corresponding author), Univ Hosp, Harrington Heart & Vasc Inst, Cleveland, OH 44106 USA.
EM sanjay.rajagopalan@uhhospitals.org
RI Chen, Zhuo/ADY-5940-2022
OI Chen, Zhuo/0000-0001-7781-2080; Khraishah, Haitham/0000-0003-0003-5089
FU  [1R35ES031702];  [R01ES017290];  [R01 ES033670-01];  [P50 MD017351-01]
FX S. Rajagopalan was supported by grants 1R35ES031702, R01ES017290, R01
   ES033670-01, and P50 MD017351-01.
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NR 135
TC 4
Z9 4
U1 4
U2 9
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0009-7330
EI 1524-4571
J9 CIRC RES
JI Circ.Res.
PD APR 26
PY 2024
VL 134
IS 9
BP 1083
EP 1097
DI 10.1161/CIRCRESAHA.124.323673
PG 15
WC Cardiac & Cardiovascular Systems; Hematology; Peripheral Vascular
   Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Hematology
GA SJ8W5
UT WOS:001234187800008
PM 38662860
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Xie, JH
   Zhang, SJ
   Yu, XF
   Yang, Y
   Liu, ZL
   Yuan, G
   Hu, SH
AF Xie, Junhui
   Zhang, Shujun
   Yu, Xuefeng
   Yang, Yan
   Liu, Zhelong
   Yuan, Gang
   Hu, Shuhong
TI Association between Liver Enzymes with Metabolically Unhealthy Obese
   Phenotype
SO LIPIDS IN HEALTH AND DISEASE
LA English
DT Article
DE Metabolically unhealthy obesity; Gamma glutamyltransferase; Alanine
   aminotransferase
ID GAMMA-GLUTAMYL-TRANSFERASE; BODY-MASS INDEX; MIDDLE-AGED MEN;
   CARDIOVASCULAR-DISEASE; INSULIN-RESISTANCE; OXIDATIVE STRESS; ALANINE
   AMINOTRANSFERASE; HEALTHY; RISK; INDIVIDUALS
AB Background: Obesity could be classified into two phenotypes: metabolically healthy obesity (MHO) and metabolically unhealthy obesity (MUHO). This study investigated the ability of liver enzymes to identify obesity phenotype.
   Methods: We conducted a cross-sectional study in 2197 obese adults (age >40 years and BMI >= 25kg/m(2)) in a rural area of central China.
   Results: In this population, 75% of the participants have more than one cardiometabolic risk factor. Both GGT and ALT were strongly related to the MUHO phenotype. The association between the fourth quartile of GGT and MUHO risk was strong and independent of confounder risk factors in both genders (adjusted ORs, 1.73 (95%CI 1.03-2.92) for male and 1.82 (95%CI 1.29-2.57) for female). The association between the fourth quartile of ALT and MUHO risk was strong and independent in female, but not in male (adjusted ORs, 1.65 (95%CI 0.86-3.19) for male and 1.88 (95%CI 1.29-2.75) for female). Additionally, AST was not associated with MUHO phenotype.
   Conclusions: Both GGT and ALT are effective markers for identifying MUHO in this population. Furthermore, the ability of GGT may be superior to ALT in male.
C1 [Xie, Junhui; Zhang, Shujun; Yu, Xuefeng; Yang, Yan; Liu, Zhelong; Yuan, Gang; Hu, Shuhong] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Endocrinol, 1095 Jiefang Rd, Wuhan 430030, Hubei, Peoples R China.
C3 Huazhong University of Science & Technology
RP Yu, XF (corresponding author), Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Endocrinol, 1095 Jiefang Rd, Wuhan 430030, Hubei, Peoples R China.
EM tjyuxfdoc@sina.com
RI 章, 述军/HJZ-0859-2023; Liu, Zhelong/IZQ-3806-2023; YU, Xuefeng/B-9332-2009
OI Liu, Zhelong/0000-0003-2567-2287
FU Chinese Society of Endocrinology; Key Laboratory for Endocrine and
   Metabolic Diseases of Ministry of Health [1994DP131044]; Nonprofit
   Industry Research Subject "Dynamic monitoring of type 2 diabetes risk
   factors and integrated community control" [201502007]
FX This survey was supported by the Chinese Society of Endocrinology, the
   Key Laboratory for Endocrine and Metabolic Diseases of Ministry of
   Health (1994DP131044). It was also supported by the grants from
   Nonprofit Industry Research Subject "Dynamic monitoring of type 2
   diabetes risk factors and integrated community control" (No. 201502007).
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NR 34
TC 10
Z9 11
U1 0
U2 6
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1476-511X
J9 LIPIDS HEALTH DIS
JI Lipids Health Dis.
PD AUG 23
PY 2018
VL 17
AR 198
DI 10.1186/s12944-018-0847-9
PG 8
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA GR2GB
UT WOS:000442382700001
PM 30134916
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Hsia, CH
   Tung, YT
   Yeh, YS
   Chien, YW
AF Hsia, Chu-Hsuan
   Tung, Yu-Tang
   Yeh, Yu-Sheng
   Chien, Yi-Wen
TI Effects of Gynura bicolor on Glycemic Control and Antioxidant
   Ability in Prediabetes
SO APPLIED SCIENCES-BASEL
LA English
DT Article
DE Gynura bicolor; prediabetes; phytochemical; blood glucose; oxidative
   stress
ID HOMEOSTASIS MODEL ASSESSMENT; FASTING PLASMA-GLUCOSE; BETA-CELL
   FUNCTION; OXIDATIVE STRESS; INSULIN SENSITIVITY; ENDOTHELIAL
   DYSFUNCTION; METABOLIC SYNDROME; BLOOD-PRESSURE; DIETARY FIBER;
   RESISTANCE
AB There exists an intermediate group of individuals whose glucose levels do not meet the criteria for diabetes yet are higher than those considered normal (prediabetes mellitus (preDM)). Those people have a higher risk of developing diabetes in the future. Gynura bicolor (GB) is a red-purple-colored vegetable, which is common in Taiwan. GB has shown antioxidant, anti-inflammatory and anti-hyperglycemic effects in previous studies. The aim of this study was to assess the effects of serving two serving sizes of GB every day on the glycemic control and antioxidant ability of preDM subjects. According to the age and anthropometry data of the participates, we assigned them into a control or GB group for the 8-week intervention and 4-week washout period. Data of anthropometry and biochemical analysis were collected at 0, 8 and 12 weeks. Oral glucose tolerance tests were performed, and we collected dietary records on the baseline and Week 8. Both groups received nutrition education and a diet plan individually. After intervention, the fasting glucose and malondialdehyde (MDA) values were significantly decreased in the GB group. HOMA-IR and QUICKI values were improved, and antioxidant activity was increased in the GB group. GB could improve glycemic control and decrease oxidative stress because of its large amounts of polyphenols.
C1 [Hsia, Chu-Hsuan; Chien, Yi-Wen] Taipei Med Univ, Sch Nutr & Hlth Sci, Taipei 11031, Taiwan.
   [Tung, Yu-Tang] Natl Chung Hsing Univ, Grad Inst Biotechnol, Taichung 402, Taiwan.
   [Yeh, Yu-Sheng] Washington Univ, Sch Med, Dept Med, Cardiovasc Div, St Louis, MO 63112 USA.
   [Chien, Yi-Wen] Taipei Med Univ, Grad Inst Metab & Obes Sci, Taipei 11031, Taiwan.
   [Chien, Yi-Wen] Taipei Med Univ Hosp, Nutr Res Ctr, Taipei 11031, Taiwan.
   [Chien, Yi-Wen] Taipei Med Univ, Coll Nutr, Res Ctr Geriatr Nutr, Taipei 11031, Taiwan.
C3 Taipei Medical University; National Chung Hsing University; Washington
   University (WUSTL); Taipei Medical University; Taipei Medical
   University; Taipei Medical University Hospital; Taipei Medical
   University
RP Chien, YW (corresponding author), Taipei Med Univ, Sch Nutr & Hlth Sci, Taipei 11031, Taiwan.; Chien, YW (corresponding author), Taipei Med Univ, Grad Inst Metab & Obes Sci, Taipei 11031, Taiwan.; Chien, YW (corresponding author), Taipei Med Univ Hosp, Nutr Res Ctr, Taipei 11031, Taiwan.; Chien, YW (corresponding author), Taipei Med Univ, Coll Nutr, Res Ctr Geriatr Nutr, Taipei 11031, Taiwan.
EM da07108003@tmu.edu.tw; peggytung@nchu.edu.tw; yu-sheng@wustl.edu;
   ychien@tmu.edu.tw
RI Yeh, Yu-Sheng/GZH-3004-2022
OI Hsia, Chu-Hsuan/0009-0000-1069-0031; Chien, Yi-wen/0000-0002-7293-5310;
   Yeh, Yu-Sheng/0000-0002-0099-2690
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NR 49
TC 4
Z9 4
U1 1
U2 6
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3417
J9 APPL SCI-BASEL
JI Appl. Sci.-Basel
PD JUN
PY 2021
VL 11
IS 11
AR 5066
DI 10.3390/app11115066
PG 13
WC Chemistry, Multidisciplinary; Engineering, Multidisciplinary; Materials
   Science, Multidisciplinary; Physics, Applied
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Engineering; Materials Science; Physics
GA SP3YO
UT WOS:000659607800001
OA gold
DA 2025-06-11
ER

PT J
AU Rusli, F
   Deelen, J
   Andriyani, E
   Boekschoten, MV
   Lute, C
   van den Akker, EB
   Müller, M
   Beekman, M
   Steegenga, WT
AF Rusli, Fenni
   Deelen, Joris
   Andriyani, Evi
   Boekschoten, Mark V.
   Lute, Carolien
   van den Akker, Erik B.
   Muller, Michael
   Beekman, Marian
   Steegenga, Wilma T.
TI Fibroblast growth factor 21 reflects liver fat accumulation and
   dysregulation of signalling pathways in the liver of C57BL/6J mice
SO SCIENTIFIC REPORTS
LA English
DT Article
ID ENDOPLASMIC-RETICULUM STRESS; SERUM FGF21 LEVELS; NONALCOHOLIC
   STEATOHEPATITIS; METABOLIC SYNDROME; GENE-EXPRESSION; BETA-KLOTHO;
   PPAR-ALPHA; TCA CYCLE; DISEASE; OBESITY
AB Fibroblast growth factor 21 (Fgf21) has emerged as a potential plasma marker to diagnose nonalcoholic fatty liver disease (NAFLD). To study the molecular processes underlying the association of plasma Fgf21 with NAFLD, we explored the liver transcriptome data of a mild NAFLD model of aging C57BL/6J mice at 12, 24, and 28 months of age. The plasma Fgf21 level significantly correlated with intrahepatic triglyceride content. At the molecular level, elevated plasma Fgf21 levels were associated with dysregulated metabolic and cancer-related pathways. The up-regulated Fgf21 levels in NAFLD were implied to be a protective response against the NAFLD-induced adverse effects, e.g. lipotoxicity, oxidative stress and endoplasmic reticulum stress. An in vivo PPAR alpha challenge demonstrated the dysregulation of PPAR alpha signalling in the presence of NAFLD, which resulted in a stochastically increasing hepatic expression of Fgf21. Notably, elevated plasma Fgf21 was associated with declining expression of Klb, Fgf21's crucial co-receptor, which suggests a resistance to Fgf21. Therefore, although liver fat accumulation is a benign stage of NAFLD, the elevated plasma Fgf21 likely indicated vulnerability to metabolic stressors that may contribute towards progression to end-stage NAFLD. In conclusion, plasma levels of Fgf21 reflect liver fat accumulation and dysregulation of metabolic pathways in the liver.
C1 [Rusli, Fenni; Andriyani, Evi; Boekschoten, Mark V.; Lute, Carolien; Steegenga, Wilma T.] Wageningen Univ, Div Human Nutr, Nutr Metab & Genom Grp, NL-6700 EV Wageningen, Netherlands.
   [Deelen, Joris; van den Akker, Erik B.; Beekman, Marian] Leiden Univ, Dept Mol Epidemiol, Med Ctr, Leiden, Netherlands.
   [van den Akker, Erik B.] Delft Univ Technol, Delft Bioinformat Lab, Mekelweg 4, NL-2628 CD Delft, Netherlands.
   [Muller, Michael] Univ East Anglia, Norwich Med Sch, Norwich, Norfolk, England.
C3 Wageningen University & Research; Leiden University - Excl LUMC; Leiden
   University; Leiden University Medical Center (LUMC); Delft University of
   Technology; University of East Anglia
RP Steegenga, WT (corresponding author), Wageningen Univ, Div Human Nutr, Nutr Metab & Genom Grp, NL-6700 EV Wageningen, Netherlands.
EM wilma.steegenga@wur.nl
RI Muller, Michael/M-5724-2019; Boekschoten, Mark/AAS-4597-2021; Deelen,
   Joris/H-3201-2019; Beekman, Marian/L-3004-2019; Muller,
   Michael/B-5795-2008
OI Beekman, Marian/0000-0003-0585-6206; Deelen, Joris/0000-0003-4483-3701;
   van den Akker, Erik/0000-0002-7693-0728; Muller,
   Michael/0000-0002-5930-9905
FU European Union's Seventh Framework Programme (FP7) IDEAL-aging [259679];
   Academy of Finland (AKA) [259679] Funding Source: Academy of Finland
   (AKA)
FX This work was financially supported by European Union's Seventh
   Framework Programme (FP7/2007-2011) IDEAL-aging under grant agreement
   no. 259679.
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NR 59
TC 73
Z9 80
U1 2
U2 28
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD JUL 29
PY 2016
VL 6
AR 30484
DI 10.1038/srep30484
PG 16
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA DS2UY
UT WOS:000380640300001
PM 27470139
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Dragoumani, K
   Troumbis, A
   Bacopoulou, F
   Chrousos, G
AF Dragoumani, Konstantina
   Troumbis, Andreas
   Bacopoulou, Flora
   Chrousos, George
TI Childhood and Adolescent Obesity with Somatic Indicators of Stress,
   Inflammation, and Dysmetabolism before and after Intervention: A
   Meta-Analysis
SO JOURNAL OF PERSONALIZED MEDICINE
LA English
DT Review
DE children; adolescents; overweight; obesity; dysmetabolism; inflammation
ID LIFE-STYLE INTERVENTION; SYSTEMATIC REVIEWS; METABOLIC SYNDROME;
   PHYSICAL-ACTIVITY; RISK-FACTORS; ADIPONECTIN; CHILDREN; MARKERS;
   HETEROGENEITY; OVERWEIGHT
AB There have been numerous attempts to establish a correlation between obesity and stress, inflammatory, and dysmetabolism biomarkers in children and adolescents. Here, we performed a meta-analysis of existing studies to shed light on the elusive correlations of childhood and adolescent obesity with physiological indicators of stress, inflammation, and metabolism before and after lifestyle interventions. Observational studies, meta-analyses, narrative and systematic reviews were excluded. From a total of 53 articles, 11 were selected according to specific criteria. The biomarkers examined were circulating glucose, insulin, HDL, LDL, triglycerides, adiponectin, leptin, CRP, TNF-alpha, interleukin (IL)-6, systolic and diastolic blood pressure, and HOMA-IR. All analyses were performed using IBM SPSS Statistics Version 28.0.1.0 (142). The current meta-analysis provides evidence of a beneficial effect of a lifestyle intervention and/or drugs in children and adolescents living with obesity or overweight, consistent with a significant reduction in body fat-but not in BMI or waist circumference-an increase in circulating adiponectin and/or a reduction in serum insulin levels and diastolic blood pressure, and a trend towards a reduction of circulating leptin and glucose levels, as well as of the HOMA-IR. This meta-analysis indicates that lifestyle interventions could reduce overweight-/obesity-associated systemic inflammation and dysmetabolism even without an apparent decrease in BMI.
C1 [Dragoumani, Konstantina] Univ Aegean, Dept Food Sci & Nutr, Lemnos 81400, Greece.
   [Troumbis, Andreas] Univ Aegean, Dept Environm Studies, Mitilini 81100, Greece.
   [Bacopoulou, Flora] Natl & Kapodistrian Univ Athens, Aghia Sophia Childrens Hosp, Ctr Adolescent Med, Sch Med, Athens 11527, Greece.
   [Bacopoulou, Flora] Natl & Kapodistrian Univ Athens, Aghia Sophia Childrens Hosp, UNESCO Chair Adolescent Hlth Care, Sch Med,Dept Pediat 1, Athens 11527, Greece.
   [Chrousos, George] Natl & Kapodistrian Univ Athens, Univ Res Inst Maternal & Child Hlth & Precis Med, Aghia Sophia Childrens Hosp, Athens 11527, Greece.
C3 University of Aegean; The Aghia Sophia Children's Hospital; National &
   Kapodistrian University of Athens; Athens Medical School; The Aghia
   Sophia Children's Hospital; Athens Medical School; National &
   Kapodistrian University of Athens; National & Kapodistrian University of
   Athens; The Aghia Sophia Children's Hospital
RP Dragoumani, K (corresponding author), Univ Aegean, Dept Food Sci & Nutr, Lemnos 81400, Greece.
EM konstantinadragoumani@gmail.com
RI DRAGOUMANI, KONSTANTINA/GWU-6137-2022; Chrousos, George/G-8702-2011;
   Bacopoulou, Flora/AAH-1218-2019
OI Dragoumani, Konstantina/0009-0001-8388-6964; Bacopoulou,
   Flora/0000-0003-1001-0926
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NR 60
TC 2
Z9 2
U1 0
U2 3
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2075-4426
J9 J PERS MED
JI J. Pers. Med.
PD SEP
PY 2023
VL 13
IS 9
AR 1322
DI 10.3390/jpm13091322
PG 19
WC Health Care Sciences & Services; Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Health Care Sciences & Services; General & Internal Medicine
GA S8QW9
UT WOS:001073769900001
PM 37763090
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Hancock, JT
   LeBaron, TW
   May, J
   Thomas, A
   Russell, G
AF Hancock, John T.
   LeBaron, Tyler W.
   May, Jennifer
   Thomas, Adam
   Russell, Grace
TI Molecular Hydrogen: Is This a Viable New Treatment for Plants in the UK?
SO PLANTS-BASEL
LA English
DT Review
DE heme; heme oxygenase; hydrogen gas; nitric oxide; postharvest; reactive
   oxygen species; redox; stress responses
ID DELAYS PETAL SENESCENCE; CLIMATE-CHANGE IMPACTS; NITRIC-OXIDE DONORS;
   RICH WATER; OXIDATIVE STRESS; OZONE DEPLETION; VASE LIFE; ANTIOXIDANT
   DEFENSE; METABOLIC SYNDROME; SEED DORMANCY
AB Despite being trialed in other regions of the world, the use of molecular hydrogen (H-2) for enhanced plant growth and the postharvest storage of crops has yet to be widely accepted in the UK. The evidence that the treatment of plants and plant products with H-2 alleviates plant stress and slows crop senescence continues to grow. Many of these effects appear to be mediated by the alteration of the antioxidant capacity of plant cells. Some effects seem to involve heme oxygenase, whilst the reduction in the prosthetic group Fe3+ is also suggested as a mechanism. Although it is difficult to use as a gaseous treatment in a field setting, the use of hydrogen-rich water (HRW) has the potential to be of significant benefit to agricultural practices. However, the use of H-2 in agriculture will only be adopted if the benefits outweigh the production and application costs. HRW is safe and relatively easy to use. If H-2 gas or HRW are utilized in other countries for agricultural purposes, it is tempting to suggest that they could also be widely used in the UK in the future, particularly for postharvest storage, thus reducing food waste.
C1 [Hancock, John T.; May, Jennifer; Thomas, Adam; Russell, Grace] Univ West England, Dept Appl Sci, Bristol BS16 1QY, Avon, England.
   [LeBaron, Tyler W.] Comenius Univ, Heart Res Inst, Fac Nat Sci, Ctr Med Expt,Slovak Acad Sci, Bratislava 84104, Slovakia.
   [LeBaron, Tyler W.] Mol Hydrogen Inst, Enoch, UT 84721 USA.
   [LeBaron, Tyler W.] Southern Utah Univ, Dept Kinesiol & Outdoor Recreat, Cedar City, UT 84720 USA.
C3 University of West England; Comenius University Bratislava; Slovak
   Academy of Sciences; Utah System of Higher Education; Southern Utah
   University
RP Hancock, JT (corresponding author), Univ West England, Dept Appl Sci, Bristol BS16 1QY, Avon, England.
EM john.hancock@uwe.ac.uk; sci_ty7@yahoo.com; Jennifer2.May@uwe.ac.uk;
   Adam7.Thomas@uwe.ac.uk; Grace.Russell@uwe.ac.uk
RI LeBaron, Tyler/GLT-7071-2022
OI LeBaron, Tyler/0000-0001-9164-6728; Hancock, John/0000-0002-0213-8850;
   Russell, Grace/0000-0002-7989-8989
FU Water Fuel Engineering
FX T.W.L. reports personal fees from medical/academic conferences including
   travel reimbursement, honoraria, and speaking and consultancy fees from
   various academic and commercial entities regarding molecular hydrogen.
   G.R. is funded in part by Water Fuel Engineering who have a commercial
   interest in hydrogen-producing technologies. All other authors report no
   conflicts of interest.
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NR 131
TC 9
Z9 9
U1 8
U2 45
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
SN 2223-7747
J9 PLANTS-BASEL
JI Plants-Basel
PD NOV
PY 2021
VL 10
IS 11
AR 2270
DI 10.3390/plants10112270
PG 16
WC Plant Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences
GA XL2RO
UT WOS:000727996700001
PM 34834633
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Caldas, APS
   Alves, RDM
   Hermsdorff, HHM
   de Oliveira, LL
   Bressan, J
AF Caldas, Ana Paula Silva
   Alves, Raquel Duarte Moreira
   Hermsdorff, Helen Hermana Miranda
   de Oliveira, Leandro Licursi
   Bressan, Josefina
TI Effects of high-oleic peanuts within a hypoenergetic diet on
   inflammatory and oxidative status of overweight men: a randomised
   controlled trial
SO BRITISH JOURNAL OF NUTRITION
LA English
DT Article
DE Inflammation; MUFA; Obesity; Oxidative stress; Peanuts
ID ALMOND CONSUMPTION; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   BODY-COMPOSITION; ADIPOSE-TISSUE; FATTY-ACIDS; MARKERS; STRESS;
   CYTOKINES; NUTS
AB The consumption of food with MUFA has been associated with improvement of inflammation and oxidative stress in overweight individuals. In the present study, we evaluate the effect of high-oleic peanut intake within a hypoenergetic diet on inflammatory and oxidative status markers in overweight men. Sixty-four overweight men (BMI 26-35 kg/m(2), 18-50 years old) participated in this randomised controlled study for 4 weeks, allocated into three groups: control (CT, n 22), conventional peanut (CVP, n 21) and high-oleic peanut (HOP, n 21). They followed a hypoenergetic diet (-250 kcal/d; -1045 kJ/d) with or without 56 g of high-oleic or conventional peanuts. After the intervention, the inflammatory markers did not show significant changes in fasting concentrations or postprandial response among the experimental groups (P > 0 center dot 05). The activity of oxidative status markers remained unchanged after the intervention. However, in the CT, malondialdehyde showed lower concentration in comparison with the baseline (P = 0 center dot 020) and among the groups (P = 0 center dot 002). In the present study, the daily intake of high-oleic peanuts within a hypoenergetic diet did not modify the inflammatory markers and oxidative status in overweight men. More studies are needed to better understand the effect of high-oleic peanut intake on health outcomes.
C1 [Caldas, Ana Paula Silva; Alves, Raquel Duarte Moreira; Hermsdorff, Helen Hermana Miranda; Bressan, Josefina] Univ Fed Vicosa, Dept Nutr & Hlth, BR-36570900 Vicosa, MG, Brazil.
   [de Oliveira, Leandro Licursi] Univ Fed Vicosa, Dept Gen Biol, BR-36570900 Vicosa, MG, Brazil.
C3 Universidade Federal de Vicosa; Universidade Federal de Vicosa
RP Caldas, APS (corresponding author), Univ Fed Vicosa, Dept Nutr & Hlth, BR-36570900 Vicosa, MG, Brazil.
EM paulacaldas06@hotmail.com
RI Caldas, Ana Paula/E-8411-2017; Bressan, Josefina/A-2598-2009; Licursi de
   Oliveira, Leandro/D-3616-2009
OI Licursi de Oliveira, Leandro/0000-0003-4353-7011; Silva Caldas, Ana
   Paula/0000-0002-7517-3323; Bressan, Josefina/0000-0002-4993-9436
FU CAPES Foundation; Brazilian Government Organization FAPEMIG [CDS
   -APQ-00771-15]
FX The CAPES Foundation provided research grant to APSC. H. H. M. H. and J.
   B. are CNPq fellows. The present project was supported by Brazilian
   Government Organization FAPEMIG (CDS -APQ-00771-15).
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NR 64
TC 13
Z9 13
U1 0
U2 8
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1145
EI 1475-2662
J9 BRIT J NUTR
JI Br. J. Nutr.
PD MAR 28
PY 2020
VL 123
IS 6
BP 673
EP 680
AR PII S0007114519003246
DI 10.1017/S0007114519003246
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA KL7WD
UT WOS:000513628200008
PM 31813384
DA 2025-06-11
ER

PT J
AU Paik, JK
   Chae, JS
   Kang, R
   Kwon, N
   Lee, SH
   Lee, JH
AF Paik, J. K.
   Chae, J. S.
   Kang, R.
   Kwon, N.
   Lee, S-H
   Lee, J. H.
TI Effect of age on atherogenicity of LDL and inflammatory markers in
   healthy women
SO NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
LA English
DT Article
DE Age; Atherogenicity; Women; Oxidative stress; Inflammatory markers
ID OXIDATIVE STRESS; CYTOKINE PRODUCTION; MONONUCLEAR-CELLS; OXIDIZED LDL;
   INTERLEUKIN-6; OBESITY; CHOLESTEROL; LIPOPROTEIN; INCREASE; DISEASE
AB Background and aim: Since using LDL level alone is insufficient as a method to identify individuals with incident coronary artery disease (CAD), other factors may be implicated in the pathogenesis of CAD. Additionally, controversy still remains regarding whether there is an age-related increase in circulating cytokines in healthy individuals. We investigated the influence of age on atherogenicity of LDL and inflammatory markers in healthy women.
   Methods and results: Two thousand nine hundred forty four healthy women form 30-79 years old (23.3 +/- 0.05 kg/m(2)) were categorized into 5 age groups: 30-39, 40-49, 50-59, 60-69 and 70-79 years. BMI, smoking, drinking, and metabolic syndrome prevalence adjusted mean values of total-cholesterol progressively increased from the group age 30-39 years to the group age 40-49 and 50-59 years and thereafter decreased in the group age 60-69 and 70-79 years. Serum concentrations of C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) were higher in women aged 60-79 years than women aged 30-59 years. Plasma ox-LDL levels increased in the group age 50-59 years compared with the group age 30-39 and 40-49 years and further increased in the group age 60-69 and 70-79 years. Mean values of LDL particle size were smaller in women aged 60-79 years than those in women aged 30-59 years. After adjustment for BMI, smoking, drinking, and metabolic syndrome status, age was positively correlated with LDL-cholesterol (r = 0.095, P < 0.001), oxidized LDL (r = 0.305, P < 0.001), hs-CRP (r = 0.150, P < 0.001), TNF-alpha (r = 0.171, P < 0.001) and IL-6 (r = 0.294, P < 0.001) and negatively with LDL particle size (r = -0.239, P < 0.001).
   Conclusion: Our results indicate that LDL atherogenicity and inflammatory mediators can be better markers of CAD risk than known risk factors such as elevated concentrations of total- and LDL-cholesterol, decreased HDL-cholesterol levels and smoking in old healthy women. (C) 2012 Elsevier B.V. All rights reserved.
C1 [Paik, J. K.; Chae, J. S.; Lee, J. H.] Yonsei Univ, Res Inst Sci Aging, Seoul 120749, South Korea.
   [Kang, R.; Kwon, N.; Lee, J. H.] Yonsei Univ, Natl Leading Res Lab Clin Nutrigenet Nutrigen, Dept Food & Nutr, Seoul 120749, South Korea.
   [Lee, S-H] Natl Hlth Insurance Corp Ilsan Hosp, Dept Family Practice, Goyang Si, South Korea.
C3 Yonsei University; Yonsei University
RP Lee, JH (corresponding author), Yonsei Univ, Coll Human Ecol, Dept Food & Nutr, 134 Shinchon Ding, Seoul 120749, South Korea.
EM jhleeb@yonsei.ac.kr
FU National Research Foundation of Korea, Republic of Korea [2012-0005604]
FX We sincerely thank the study subjects for their participation. This
   study was supported by the National Research Foundation of Korea
   (2012-0005604), Republic of Korea. All the authors were involved in the
   development of the study protocol and the experimental design.
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NR 27
TC 34
Z9 38
U1 0
U2 9
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0939-4753
EI 1590-3729
J9 NUTR METAB CARDIOVAS
JI Nutr. Metab. Carbiovasc. Dis.
PD OCT
PY 2013
VL 23
IS 10
BP 967
EP 972
DI 10.1016/j.numecd.2012.08.002
PG 6
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism; Nutrition
   & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism;
   Nutrition & Dietetics
GA 239AG
UT WOS:000325993200010
PM 23021775
DA 2025-06-11
ER

PT J
AU Murunga, AN
   Miruka, DO
   Driver, C
   Nkomo, FS
   Cobongela, SZZ
   Owira, PMO
AF Murunga, Alfred N.
   Miruka, David O.
   Driver, Christine
   Nkomo, Fezile S.
   Cobongela, Snazo Z. Z.
   Owira, Peter M. O.
TI Grapefruit Derived Flavonoid Naringin Improves Ketoacidosis and Lipid
   Peroxidation in Type 1 Diabetes Rat Model
SO PLOS ONE
LA English
DT Article
ID OXIDATIVE STRESS; METABOLIC SYNDROME; CITRUS FLAVONOIDS; HYPERGLYCEMIA;
   DYSLIPIDEMIA; HESPERIDIN; DIAGNOSIS; MELLITUS
AB Background
   Hypoglycemic effects of grapefruit juice are well known but the effects of naringin, its main flavonoid on glucose intolerance and metabolic complications in type 1 diabetes are not known.
   Objectives
   To investigate the effects of naringin on glucose intolerance, oxidative stress and ketonemia in type 1 diabetic rats.
   Methods
   Sprague-Dawley rats divided into 5 groups (n = 7) were orally treated daily with 3.0 ml/kg body weight (BW)/day of distilled water (group 1) or 50 mg/kg BW of naringin (groups 2 and 4, respectively). Groups 3, 4 and 5 were given a single intra-peritoneal injection of 60 mg/kg BW of streptozotocin to induce diabetes. Group 3 was further treated with subcutaneous insulin (4.0 IU/kg BW) twice daily, respectively.
   Results
   Stretozotocin (STZ) only-treated groups exhibited hyperglycemia, polydipsia, polyuria, weight loss, glucose intolerance, low fasting plasma insulin and reduced hepatic glycogen content compared to the control group. Furthermore they had significantly elevated Malondialdehyde (MDA), acetoacetate, beta-hydroxybutyrate, anion gap and significantly reduced blood pH and plasma bicarbonate compared to the control group. Naringin treatment significantly improved Fasting Plasma Insulin (FPI), hepatic glycogen content, malondialdehyde, beta-hydroxybutyrate, acetoacetate, bicarbonate, blood pH and anion gap but not Fasting Blood Glucose (FBG) compared to the STZ only-treated group.
   Conclusions
   Naringin is not hypoglycemic but ameliorates ketoacidosis and oxidative stress. Naringin supplements could therefore mitigate complications of diabetic ketoacidosis.
C1 [Murunga, Alfred N.; Miruka, David O.; Driver, Christine; Nkomo, Fezile S.; Cobongela, Snazo Z. Z.; Owira, Peter M. O.] Univ KwaZulu Natal, Mol & Clin Pharmacol Res Lab, Dept Pharmacol, Discipline Pharmaceut Sci,Sch Hlth Sci, POB X5401, Durban, South Africa.
C3 University of Kwazulu Natal
RP Owira, PMO (corresponding author), Univ KwaZulu Natal, Mol & Clin Pharmacol Res Lab, Dept Pharmacol, Discipline Pharmaceut Sci,Sch Hlth Sci, POB X5401, Durban, South Africa.
EM owirap@ukzn.ac.za
OI Cobongela, Sinazo/0000-0001-9057-3096
FU Career Development Award by South African Medical Research Council
FX The study was funded by Career Development Award by the South African
   Medical Research Council to the corresponding author.
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NR 33
TC 39
Z9 47
U1 0
U2 11
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD APR 13
PY 2016
VL 11
IS 4
AR e0153241
DI 10.1371/journal.pone.0153241
PG 16
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA DJ3UC
UT WOS:000374131200065
PM 27073901
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Romain, C
   Bresciani, L
   Gaillet, S
   Feillet-Coudray, C
   Calani, L
   Bonafos, B
   Vidé, J
   Rugani, N
   Ramos, J
   Del Rio, D
   Cristol, JP
   Rouanet, JM
AF Romain, Cindy
   Bresciani, Letizia
   Gaillet, Sylvie
   Feillet-Coudray, Christine
   Calani, Luca
   Bonafos, Beatrice
   Vide, Joris
   Rugani, Nathalie
   Ramos, Jeanne
   Del Rio, Daniele
   Cristol, Jean-Paul
   Rouanet, Jean-Max
TI Moderate chronic administration of Vineatrol-enriched red wines improves
   metabolic, oxidative, and inflammatory markers in hamsters fed a
   high-fat diet
SO MOLECULAR NUTRITION & FOOD RESEARCH
LA English
DT Article
DE Atherosclerosis; Liver inflammation; Oxidative stress; Stilbene-rich
   wines; Vineatrol 30 (R)
ID ANTIOXIDANT ACTIVITY; INSULIN-RESISTANCE; SERUM PARAOXONASE;
   LIVER-DISEASE; STRESS; RESVERATROL; EXTRACT; POLYPHENOLS; SIRT1; RATS
AB Scope: High-fat (HF) diets contribute to the development of cardiovascular diseases and the metabolic syndrome. This study was undertaken to investigate the beneficial effects of Vineatrol (R)-enriched red wines on blood lipids, oxidative stress and inflammation, and the role of some metabolic pathway regulatory proteins.
   Methods and results: Golden Syrian hamsters received an HF diet for 13 wk, in the presence or absence of red wines supplemented with Vineatrol (R) (RWV) or not. The HF diet increased plasma cholesterol, triglycerides, glucose, and insulin, which were attenuated by RWV treatment. RWV protected against the HF-induced increase in liver nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity and spared antioxidant enzyme activities. RWV did not reduce either liver steatosis or increased plasma leptin due to the HF diet, but greatly improved adiponectinemia. In the liver, RWV affected the inflammatory response by decreasing polymorphonuclear cell number and lowering TNF-alpha and IL-6 levels. Moreover, the increase in NF-kappa B activity in the HF group liver was prevented by RWV. Finally, RWV partially corrected low SIRT1 levels due to the HF diet but had no influence on SIRT3 or p-AMPK protein levels.
   Conclusion: Our studies suggest that RWV is capable of reversing the atherogenic process induced by an HF diet in hamster tissues.
C1 [Romain, Cindy; Gaillet, Sylvie; Vide, Joris; Rugani, Nathalie; Cristol, Jean-Paul; Rouanet, Jean-Max] Univ Montpellier South France, UMR NUTRIPASS 204, F-34095 Montpellier 05, France.
   [Bresciani, Letizia; Calani, Luca; Del Rio, Daniele] Univ Parma, Dept Food Sci, Human Nutr Unit, Lab Phytochem Physiol 2, I-43100 Parma, Italy.
   [Bresciani, Letizia; Calani, Luca; Del Rio, Daniele] Univ Parma, Dept Food Sci Bioact & Hlth LS9, Interlab Grp, I-43100 Parma, Italy.
   [Feillet-Coudray, Christine; Bonafos, Beatrice] INRA Montpellier Ctr, UMR Dynam Muscle & Metab 866, Montpellier, France.
   [Ramos, Jeanne] Guy de Chauliac Hosp, Univ Ctr, Montpellier, France.
C3 University of Parma; University of Parma; INRAE; Universite de
   Montpellier; CHU de Montpellier
RP Rouanet, JM (corresponding author), Univ Montpellier South France, UMR NutriPass, CC 023, Pl Eugene Bataillon, F-34095 Montpellier 05, France.
EM jm.rouanet@univ-montp2.fr
RI COUDRAY, Charles/AGG-4757-2022; Del Rio, Daniele/E-8696-2010
OI Bresciani, Letizia/0000-0002-7768-4987; Del Rio,
   Daniele/0000-0001-5394-1259; , Jean-Paul Cristol/0000-0001-8563-7278
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NR 63
TC 16
Z9 16
U1 0
U2 25
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1613-4125
EI 1613-4133
J9 MOL NUTR FOOD RES
JI Mol. Nutr. Food Res.
PD JUN
PY 2014
VL 58
IS 6
BP 1212
EP 1225
DI 10.1002/mnfr.201300853
PG 14
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA AJ4XQ
UT WOS:000337683500006
PM 24585438
DA 2025-06-11
ER

PT J
AU Lu, JP
   Hou, ZF
   Duivenvoorden, WC
   Whelan, K
   Honig, A
   Pinthus, JH
AF Lu, J-P
   Hou, Z. F.
   Duivenvoorden, W. C.
   Whelan, K.
   Honig, A.
   Pinthus, J. H.
TI Adiponectin inhibits oxidative stress in human prostate carcinoma cells
SO PROSTATE CANCER AND PROSTATIC DISEASES
LA English
DT Article
DE adiponectin; obesity; oxidative stress
ID SERUM ADIPONECTIN; METABOLIC SYNDROME; CANCER; OBESITY; RISK;
   ASSOCIATION; ACTIVATION; PREVENTION; RECEPTORS; DIAGNOSIS
AB BACKGROUND: Emerging data suggest that obesity increases the risk of aggressive prostate cancer (PC), but the mechanisms underlying this relationship remain to be fully elucidated. Oxidative stress (OS) is a key process in the development and progression of PC. Adiponectin, an adipocyte-specific hormone, circulates at relatively high levels in healthy humans, but at reduced levels in obese subjects. Moreover, case-control studies also document lower levels of serum adiponectin in PC patients compared with healthy individuals.
   METHODS: Human 22Rv1 and DU-145 PC cell lines were examined for the generation of OS and detoxification of reactive oxygen species after treatment with adiponectin. Normality was confirmed using the Shapiro-Wilk test and results were analyzed using a one-way analysis of variance.
   RESULTS: We demonstrate that adiponectin increased cellular anti-oxidative defense mechanisms and inhibited OS in a significant and dose-dependent manner. We show that adiponectin treatment decreased the generation of superoxide anion in both cell lines, whereas the transcript levels of NADPH oxidase (NOX)2 and NOX4 increased. We also found indications of an overall anti-oxidative effect, as the total anti-oxidative potential, catalase activity and protein levels, and manganese superoxide dismutase protein levels increased significantly (P<0.05) in both cell lines after treatment with adiponectin.
   CONCLUSION: Lower levels of adiponectin in obese individuals may result in higher levels of prostatic OS, which may explain the clinical association between obesity, hypoadiponectinemia and PC.
C1 [Lu, J-P; Hou, Z. F.; Duivenvoorden, W. C.; Whelan, K.; Honig, A.; Pinthus, J. H.] Juravinski Canc Ctr, Dept Surg Oncol, Hamilton, ON L8V 5C2, Canada.
   [Lu, J-P; Hou, Z. F.; Duivenvoorden, W. C.; Whelan, K.; Honig, A.; Pinthus, J. H.] McMaster Univ, Dept Surg, Div Urol, Hamilton, ON L8S 4L8, Canada.
C3 McMaster University; McMaster University
RP Pinthus, JH (corresponding author), Juravinski Canc Ctr, Dept Surg Oncol, 699 Concess St, Hamilton, ON L8V 5C2, Canada.
EM jehonathan.pinthus@jcc.hhsc.ca
RI Pinthus, Jehonathan/AAQ-1667-2021; Duivenvoorden, Wilhelmina/F-1512-2016
FU Juravinski Cancer Center Foundation; Prostate Cancer Foundation of
   Canada
FX This study was funded by grants to JHP by the Juravinski Cancer Center
   Foundation and the Prostate Cancer Foundation of Canada.
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NR 37
TC 33
Z9 38
U1 0
U2 4
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1365-7852
EI 1476-5608
J9 PROSTATE CANCER P D
JI Prostate Cancer Prostatic Dis.
PD MAR
PY 2012
VL 15
IS 1
BP 28
EP 35
DI 10.1038/pcan.2011.53
PG 8
WC Oncology; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Urology & Nephrology
GA 896YT
UT WOS:000300608100004
PM 22249290
OA Bronze
DA 2025-06-11
ER

PT J
AU Lemkes, BA
   Hermanides, J
   Devries, JH
   Holleman, F
   Meijers, JCM
   Hoekstra, JBL
AF Lemkes, B. A.
   Hermanides, J.
   Devries, J. H.
   Holleman, F.
   Meijers, J. C. M.
   Hoekstra, J. B. L.
TI Hyperglycemia: a prothrombotic factor?
SO JOURNAL OF THROMBOSIS AND HAEMOSTASIS
LA English
DT Review
DE coagulation; diabetes; fibrinolysis; hyperglycemia and thrombosis
ID ACUTE MYOCARDIAL-INFARCTION; TYPE-2 DIABETES-MELLITUS;
   GLUCOSE-INSULIN-POTASSIUM; PLASMINOGEN-ACTIVATOR INHIBITOR; FACTOR
   PROCOAGULANT ACTIVITY; CARDIOVASCULAR RISK-FACTORS; CRITICALLY-ILL
   PATIENTS; GLYCEMIC CONTROL; STRESS HYPERGLYCEMIA; METABOLIC SYNDROME
AB Diabetes mellitus is characterized by a high risk of atherothrombotic events. What is more, venous thrombosis has also been found to occur more frequently in this patient group. This prothrombotic condition in diabetes is underpinned by laboratory findings of elevated coagulation factors and impaired fibrinolysis. Hyperglycemia plays an important role in the development of these hemostatic abnormalities, as is illustrated by the association with glycemic control and the improvement upon treatment of hyperglycemia. Interestingly, stress induced hyperglycemia, which is often transient, has also been associated with poor outcome in thrombotic disease. Similar laboratory findings suggest a common effect of acute vs. chronic hyperglycemia on the coagulation system. Many mechanisms have been proposed to explain this prothrombotic shift in hyperglycemia, such as a direct effect on gene transcription of coagulation factors caused by hyperglycemia-induced oxidative stress, loss of the endothelial glycocalyx layer, which harbours coagulation factors, and direct glycation of coagulation factors, altering their activity. In addition, both chronic and acute hyperglycemia are often accompanied by hyperinsulinemia, which has been shown to have prothrombotic effects as well. In conclusion, the laboratory evidence of the effects of both chronic and acute hyperglycemia suggests a prothrombotic shift. Additionally, hyperglycemia is associated with poor clinical outcome of thrombotic events. Whether intensive treatment of hyperglycemia can prevent hypercoagulability and improve clinical outcome remains to be investigated.
C1 [Lemkes, B. A.; Hermanides, J.; Devries, J. H.; Holleman, F.; Hoekstra, J. B. L.] Acad Med Ctr, Dept Internal Med, NL-1100 DD Amsterdam, Netherlands.
   [Meijers, J. C. M.] Acad Med Ctr, Dept Vasc Med, NL-1100 DD Amsterdam, Netherlands.
C3 University of Amsterdam; Academic Medical Center Amsterdam; University
   of Amsterdam; Academic Medical Center Amsterdam
RP Lemkes, BA (corresponding author), Acad Med Ctr, Dept Internal Med, F4-257,POB 22660, NL-1100 DD Amsterdam, Netherlands.
EM b.a.lemkes@amc.uva.nl
RI DeVries, J Hans/GPF-7277-2022; Meijers, J.C.M./S-5981-2019
OI Holleman, Frits/0000-0001-5858-5089; DeVries, J.
   Hans/0000-0001-9196-9906; Hermanides, Jeroen/0000-0003-2239-1260
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NR 83
TC 230
Z9 242
U1 0
U2 21
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1538-7933
EI 1538-7836
J9 J THROMB HAEMOST
JI J. Thromb. Haemost.
PD AUG
PY 2010
VL 8
IS 8
BP 1663
EP 1669
DI 10.1111/j.1538-7836.2010.03910.x
PG 7
WC Hematology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Hematology; Cardiovascular System & Cardiology
GA 635HN
UT WOS:000280646300001
PM 20492456
OA Bronze
DA 2025-06-11
ER

PT J
AU Kim, MK
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AF Kim, Mi Kyung
   Chung, Sang Woon
   Kim, Dae Hyun
   Kim, Ji Min
   Lee, Eun Kyeong
   Kim, Ji Young
   Ha, Young Mi
   Kim, Yun Hee
   No, Jae-Kyung
   Chung, Hye Sun
   Park, Kun-Young
   Rhee, Sook Hee
   Choi, Jae Sue
   Yu, Byung Pal
   Yokozawa, Takako
   Kim, Young Jin
   Chung, Hae Young
TI Modulation of age-related NF-κB activation by dietary zingerone via MAPK
   pathway
SO EXPERIMENTAL GERONTOLOGY
LA English
DT Article
DE Zingerone; ROS; Oxidative stress; NF-kappa B; Aging; Anti-inflammatory
ID INFLAMMATION HYPOTHESIS; CALORIE RESTRICTION; GENE-EXPRESSION; GINGER;
   STRESS; CONSTITUENTS; KINASE; ENZYME; SIGNAL
AB Zingerone, a major component found in ginger root, has been known as anti-mutagenic and anti-carcinogenic activities that are often associated with its anti-oxidative and anti-inflammatory activities. In recent studies, we examined molecular mechanism of zingerone treatment on pro-inflammatory NF-kappa B activation via the redox-related NIK/IKK and MAPK pathways. Action mechanism of zingerone on NF-kappa B signaling was investigated in aged rat kidney and endothelial cells. The results showed that zingerone had not only the antioxidant effect by constitutive suppression of ROS, but also anti-inflammatory effects by suppression of nuclear factor (NF)-kappa B activation in aged rat. In addition, zingerone treatment suppressed gene activation of pro-inflammatory enzymes, COX-2 and iNOS, which were upregulated with aging through NF-kappa B activation and IKK/MAPK signaling pathway. These experiments strongly indicate that zingerone treatment exerts a beneficial efficacy by suppressing both oxidative stress and age-related inflammation through the modulation of several key pro-inflammatory genes and transcription factors. Thus, the significance of our findings is that the zingerone treatment may provide some preventive measure against chronic inflammatory conditions that underlie many age-related inflammatory diseases, such as metabolic syndrome, cardiovascular disease, dementia, arthritis, diabetes, osteoprosis, and cancers. (C) 2010 Elsevier Inc. All rights reserved.
C1 [Kim, Mi Kyung; Chung, Sang Woon; Kim, Dae Hyun; Kim, Ji Min; Lee, Eun Kyeong; Kim, Ji Young; Ha, Young Mi; Chung, Hae Young] Pusan Natl Univ, Dept Pharm, Pusan 609735, South Korea.
   [Kim, Mi Kyung; Chung, Sang Woon; Kim, Dae Hyun; Kim, Ji Min; Lee, Eun Kyeong; Kim, Ji Young; Ha, Young Mi; Chung, Hae Young] Pusan Natl Univ, Dept Mol Inflammat Res Ctr Aging Intervent MRCA, Pusan 609735, South Korea.
   [Kim, Yun Hee] Dong Pusan Coll Univ, Hlth Promot Div, Busan Metropolitan City, South Korea.
   [No, Jae-Kyung] Dong Pusan Coll Univ, Dept Beauty Art, Pusan 612715, South Korea.
   [Chung, Hye Sun; Park, Kun-Young; Rhee, Sook Hee] Pusan Natl Univ, Dept Food Sci & Nutr, Pusan 609735, South Korea.
   [Choi, Jae Sue] Pukyong Natl Univ, Fac Food Sci & Biotechnol, Pusan 608737, South Korea.
   [Yu, Byung Pal] Univ Texas Hlth Sci Ctr San Antonio, Dept Physiol, San Antonio, TX 78229 USA.
   [Yokozawa, Takako] Toyama Univ, Inst Nat Sci, Toyama 930, Japan.
   [Kim, Young Jin] Pusan Natl Univ, Dept Mol Biol, Pusan 609735, South Korea.
C3 Pusan National University; Pusan National University; Pusan National
   University; Pukyong National University; University of Texas System;
   University of Texas Health Science Center at San Antonio; University of
   Toyama; Pusan National University
RP Chung, HY (corresponding author), Pusan Natl Univ, Dept Pharm, Pusan 609735, South Korea.
EM yjinkim@pusan.ac.kr; hyjung@pusan.ac.kr
FU Korea government (MEST) [20090083538, 200700376]; Pusan National
   University
FX This work was supported by National Research Foundation of Korea (NRF)
   grant funded by the Korea government (MEST) (No. 20090083538 and
   200700376). This study was also financially supported by Pusan National
   University in program Post-Doc 2009. We thank Aging Tissue Bank for
   supplying aged tissue.
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NR 43
TC 111
Z9 114
U1 0
U2 13
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0531-5565
EI 1873-6815
J9 EXP GERONTOL
JI Exp. Gerontol.
PD JUN
PY 2010
VL 45
IS 6
BP 419
EP 426
DI 10.1016/j.exger.2010.03.005
PG 8
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA 603ZA
UT WOS:000278245600004
PM 20211236
DA 2025-06-11
ER

PT J
AU Carrasco-Wong, I
   Hernández, C
   Jara-Gutiérrez, C
   Porras, O
   Casanello, P
AF Carrasco-Wong, Ivo
   Hernandez, Cherie
   Jara-Gutierrez, Carlos
   Porras, Omar
   Casanello, Paola
TI Human umbilical artery endothelial cells from Large-for-Gestational-Age
   newborn have increased antioxidant efficiency and gene expression
SO JOURNAL OF CELLULAR PHYSIOLOGY
LA English
DT Article
DE endothelial cells; epigenetics; large-for-gestational-age (LGA);
   maternal obesity; oxidative stress
ID NITRIC-OXIDE SYNTHASE; OXIDATIVE STRESS; MATERNAL OBESITY; RESPONSE
   ELEMENT; DEVELOPMENTAL ORIGINS; METABOLIC SYNDROME; GLUTATHIONE; NRF2;
   ACTIVATION; DISEASE
AB Obesity is a public health problem worldwide, and especially in women in reproductive age where more than one in three have obesity. Maternal obesity is associated with an increased maternal, placental, and newborn oxidative stress, which has been proposed as a central factor in vascular dysfunction in large-for-gestational-age (LGA) newborn. However, cellular and molecular mechanisms behind this effect have not been elucidated. Untreated human umbilical artery endothelial cells (HUAEC) from LGA (LGA-HUAEC) presented higher O-2(-) levels, superoxide dismutase activity and heme oxygenase 1 messenger RNA (mRNA) levels, paralleled by reduced GSH:GSSG ratio and NRF2 mRNA levels. In response to an oxidative challenge (hydrogen peroxide), only HUAEC from LGA exhibited an enhanced Glutathione Peroxidase 1 (GPX1) expression, as well as a more efficient antioxidant machinery measured by the biosensor probe, HyPer. An open state of chromatin in the TSS region of GPX1 in LGA-HUAEC was evidenced by the DNase-HS assay. Altogether, our data indicate that LGA-HUAEC have an altered cellular and molecular antioxidant system. We propose that a chronic pro-oxidant intrauterine milieu, as evidenced in pregestational obesity, could induce a more efficient antioxidant system in fetal vascular cells, which could be maintained by epigenetic mechanism during postnatal life.
C1 [Carrasco-Wong, Ivo] Pontificia Univ Catolica Chile, Fac Biol Sci, Cell & Mol Biol PhD Program, Dept Cellular & Mol Biol, Santiago, Chile.
   [Hernandez, Cherie; Casanello, Paola] Pontificia Univ Catolica Chile, Sch Med, Dept Obstet, Santiago, Chile.
   [Jara-Gutierrez, Carlos] Univ Valparaiso, Lab Estres Oxidat, Fac Med, CIB, Valparaiso, Chile.
   [Porras, Omar] Univ Chile, INTA, Inst Nutr & Tecnol, Unidad Nutr Basica, Santiago, Chile.
   [Casanello, Paola] Pontificia Univ Catolica Chile, Sch Med, Dept Neonatol, Santiago, Chile.
   [Carrasco-Wong, Ivo] Univ Valparaiso, Sch Med, Biomed Res Ctr, Valparaiso, Chile.
C3 Pontificia Universidad Catolica de Chile; Pontificia Universidad
   Catolica de Chile; Universidad de Valparaiso; Universidad de Chile;
   Pontificia Universidad Catolica de Chile; Universidad de Valparaiso
RP Carrasco-Wong, I (corresponding author), Pontificia Univ Catolica Chile, Fac Biol Sci, PhD Program Cell & Mol Biol, Avda Libertador Bernardo OHiggins 340, Santiago, Chile.; Casanello, P (corresponding author), Pontificia Univ Catolica Chile, Sch Med, Dept Neonatol, Dept Obstet, Marcoleta 391, Santiago, Chile.
EM icarrasco@uc.cl; pcasane@uc.cl
RI Carrasco-Wong, Ivo/S-5521-2019; Casanello, Paola/X-7443-2019; Porras,
   Omar/H-7913-2013
OI Carrasco-Wong, Ivo/0000-0003-1020-734X; Jara Gutierrez,
   Carlos/0000-0002-7194-6595; Casanello, Paola/0000-0002-2355-1476;
   Porras, Omar/0000-0001-6314-9345
FU Comision Nacional de Investigacion Cientifica y Tecnologica [FONDECYT
   1171406, PIA-ANILLO ACT172097, FONDECYT 1120201]; Chilean National Fund
   for Scientific and Technological Development
FX Comision Nacional de Investigacion Cientifica y Tecnologica, Grant/Award
   Numbers: FONDECYT 1171406, PIA-ANILLO ACT172097, FONDECYT 1120201;
   Chilean National Fund for Scientific and Technological Development
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NR 60
TC 1
Z9 1
U1 0
U2 15
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0021-9541
EI 1097-4652
J9 J CELL PHYSIOL
JI J. Cell. Physiol.
PD OCT
PY 2019
VL 234
IS 10
BP 18571
EP 18586
DI 10.1002/jcp.28494
PG 16
WC Cell Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Physiology
GA IH7ML
UT WOS:000474688200156
PM 30937903
DA 2025-06-11
ER

PT J
AU Bártíková, H
   Bousová, I
   Matousková, P
   Szotáková, B
   Skálová, L
AF Bartikova, Hana
   Bousova, Iva
   Matouskova, Petra
   Szotakova, Barbora
   Skalova, Lenka
TI Effect of Green Tea Extract-Enriched Diets on Insulin and Leptin Levels,
   Oxidative Stress Parameters and Antioxidant Enzymes Activities in Obese
   Mice
SO POLISH JOURNAL OF FOOD AND NUTRITION SCIENCES
LA English
DT Article
DE monosodium glutamate-induced obesity; catechins; oxidative stress;
   polyphenon 60
ID GLUTATHIONE-S-TRANSFERASE; PHASE-II ENZYMES; MONOSODIUM GLUTAMATE;
   METABOLIC SYNDROME; DOSAGE SCHEMES; MOUSE MODEL; IN-VIVO; CANCER; RATS;
   POLYPHENOLS
AB Green tea and green tea extracts (GTE) are often incorporated into diet intended to weight reduction, although the information about their efficacy in obese individuals is insufficient. The present study was designed to follow up the effect of defined and standardized GTE in mice with obesity induced by monosodium L-glutamate. Obese mice were fed with GTE-supplemented diet in three dosage regimens: 28-day and 3-day intake of 1 g GTE in 1 kg of diet and 28-day intake of 0.1 g GTE in 1 kg of diet. The information on body weight, food intake, oxidation stress parameters in blood and antioxidant enzymes activity in liver and small intestine was obtained. High doses of GTE decreased the specific activities of glutathione reductase and catalase and increased concentrations of malondialdehyde in blood. Specific activities of antioxidant enzymes in the liver and small intestine were not altered after GTE treatment except the decrease of NAD(P)H:quinone oxidoreductase activity. Our results showed that GTE did not affect average body weight and did not markedly improve antioxidant status in glutamate-induced obese mice. Moreover, intake of high doses of GTE made antioxidant defense in obese animals even worse.
C1 [Bartikova, Hana; Bousova, Iva; Matouskova, Petra; Szotakova, Barbora; Skalova, Lenka] Charles Univ Prague, Fac Pharm, Dept Biochem Sci, Heyrovskeho 1203, CZ-50005 Hradec Kralove, Czech Republic.
C3 Charles University Prague
RP Skálová, L (corresponding author), Charles Univ Prague, Fac Pharm, Dept Biochem Sci, Heyrovskeho 1203, CZ-50005 Hradec Kralove, Czech Republic.
EM lenka.skalova@faf.cuni.cz
RI Matoušková, Petra/AAL-1360-2021; Bousova, Iva/S-5572-2017; Skalova,
   Lenka/S-9187-2017; Matouskova, Petra/S-5687-2017; Szotakova,
   Barbora/S-8742-2017
OI Bousova, Iva/0000-0003-2863-717X; Skalova, Lenka/0000-0003-0741-3871;
   Matouskova, Petra/0000-0002-9421-5744; Szotakova,
   Barbora/0000-0002-0377-0743
FU Czech Science Foundation [P303/12/G163]
FX This work was supported by the Czech Science Foundation (grant No
   P303/12/G163).
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NR 40
TC 7
Z9 7
U1 0
U2 65
PU DE GRUYTER POLAND SP ZOO
PI WARSAW
PA BOGUMILA ZUGA 32A STR., 01-811 WARSAW, POLAND
SN 1230-0322
EI 2083-6007
J9 POL J FOOD NUTR SCI
JI Pol. J. food Nutr. Sci.
PD SEP
PY 2017
VL 67
IS 3
BP 233
EP 240
DI 10.1515/pjfns-2017-0004
PG 8
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA ES8LA
UT WOS:000399807300008
OA gold
DA 2025-06-11
ER

PT J
AU Sihali-Beloui, O
   Aroune, D
   Benazouz, F
   Hadji, A
   El-Aoufi, S
   Marco, S
AF Sihali-Beloui, Ouahiba
   Aroune, Djamila
   Benazouz, Fella
   Hadji, Adile
   El-Aoufi, Salima
   Marco, Sergio
TI A hypercaloric diet induces hepatic oxidative stress, infiltration of
   lymphocytes, and mitochondrial reshuffle in Psammomys obesus, a
   murine model of insulin resistance
SO COMPTES RENDUS BIOLOGIES
LA English
DT Article
DE Psammomys obesus; Liver injury; Oxidative stress; Adaptive inflammation;
   Mitochondrial dynamics
ID ADAPTIVE IMMUNE-RESPONSES; LIPID-PEROXIDATION; MECHANISMS; AUTOPHAGY;
   FUSION; PATHOGENESIS; INFLAMMATION; METABOLISM; STEATOSIS; HUMANS
AB The aim of this study was to show, for the first time, the effect of a hypercaloric diet on the mitochondrial reshuffle of hepatocytes during the progression from steatosis to steatohepatitis to cirrhosis in Psammomys obesus, a typical animal model of the metabolic syndrome. Metabolic and oxidative stresses were induced by feeding the animal through a standard laboratory diet (SD) for nine months. Metabolic parameters, liver malondialdehyde (MDA) and glutathione (GSH), were evaluated. The pathological evolution was examined by histopathology and immunohistochemistry, using CD3 and CD20 antibodies. The dynamics of the mitochondrial structure was followed by transmission electron microscopy. SD induced a steatosis in this animal that evolved under the effect of oxidative and metabolic stress by the appearance of adaptive inflammation and fibrosis leading the animal to the cirrhosis stage with serious hepatocyte damage by the triggering, at first the mitochondrial fusion-fission cycles, which attempted to maintain the mitochondria intact and functional, but the hepatocellular oxidative damage was increased inducing a vicious circle of mitochondrial alteration and dysfunction and their elimination by mitophagy. P. obesus is an excellent animal model of therapeutic research that targets mitochondrial dysfunction in the progression of steatosis. (C) 2019 Academie des sciences. Published by Elsevier Masson SAS. All rights reserved.
C1 [Sihali-Beloui, Ouahiba; Aroune, Djamila; Benazouz, Fella; El-Aoufi, Salima] Univ Sci & Technol Houari Boumediene USTHB, Fac Biol Sci, Lab Biol & Physiol Organisms Mol Modelling Endoth, POB 32, Dar El Beida 16111, Alger, Algeria.
   [Hadji, Adile] Djillali Bounaama Hosp, Pathol Anat & Cytol Serv, Douera Alger, Algeria.
   [Marco, Sergio] Inst Curie, Ctr Rech, F-91405 Orsay, France.
   [Marco, Sergio] INSERM, U1196, F-91405 Orsay, France.
   [Marco, Sergio] CNRS, UMR9187, F-91405 Orsay, France.
   [Marco, Sergio] Univ Paris Saclay, Univ Paris Sud, F-91190 St Auban, France.
C3 University Science & Technology Houari Boumediene; UNICANCER; Universite
   PSL; Institut Curie; Institut National de la Sante et de la Recherche
   Medicale (Inserm); Universite Paris Saclay; Universite Paris Saclay;
   Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of
   Chemistry (INC); Universite Paris Saclay
RP Sihali-Beloui, O (corresponding author), Univ Sci & Technol Houari Boumediene USTHB, Fac Biol Sci, Lab Biol & Physiol Organisms Mol Modelling Endoth, POB 32, Dar El Beida 16111, Alger, Algeria.
EM obeloui@yahoo.fr
FU General Direction of Scientific Research and Development of Technology,
   Ministry of Higher Education and Scientific Research, "DGRSDT-MESRS'',
   Algeria
FX This research is supported by the General Direction of Scientific
   Research and Development of Technology, Ministry of Higher Education and
   Scientific Research, "DGRSDT-MESRS'', Algeria.
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NR 57
TC 8
Z9 8
U1 0
U2 2
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 1631-0691
EI 1768-3238
J9 CR BIOL
JI C. R. Biol.
PD JUN-AUG
PY 2019
VL 342
IS 5-6
BP 209
EP 219
DI 10.1016/j.crvi.2019.04.003
PG 11
WC Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics
GA JA1PJ
UT WOS:000487588600010
PM 31151779
DA 2025-06-11
ER

PT J
AU Queiroz, MIC
   Sales, MVS
   Barros, EDS
   D'Amato, FOS
   Gonçalves, CM
   Ursulino, JS
   Bueno, NB
   Marinho, C
   Rocha, U
   Aquino, TM
   Fonseca, EJS
   Borbely, AU
   Oliveira, HCF
   Santos, JCC
   Leite, ACR
AF Queiroz, Maiara I. C.
   Sales, Marcos V. S.
   Barros, Ellen dos Santos Silva
   D'Amato, Flavio O. S.
   Goncalves, Camilla M.
   Ursulino, Jeferson S.
   Bueno, Nassib B.
   Marinho, Chiara
   Rocha, Ueslen
   Aquino, Thiago M.
   Fonseca, Eduardo Jorge S.
   Borbely, Alexandre U.
   Oliveira, Helena C. F.
   Santos, Josue Carinhanha C.
   Leite, Ana Catarina R.
TI Exposure to a contaminated environment and its relationship with human
   health: Mercury effect on loss of functionality and increased oxidative
   stress of blood cells
SO JOURNAL OF HAZARDOUS MATERIALS
LA English
DT Article
DE Mercury; Contaminated environment; Munda & uacute; Lagoon; Blood cells
ID METABOLIC SYNDROME; PROTEIN CARBONYLATION; ANTIOXIDANT STATUS; INORGANIC
   MERCURY; INDUCED APOPTOSIS; DNA-DAMAGE; GLUTATHIONE; HEMOGLOBIN;
   NECROSIS; OXYGEN
AB Recent findings indicate elevated levels of total Hg in the waters of the Lagoa Munda & uacute;-Manguaba Estuarine Complex (CELMM, Maceio<acute accent>-AL, Brazil) and the biological fluids of fishermen that live near CELMM. This study assessed Hg levels in whole blood and the functionality, structure, morphology, and oxidative stress of blood cells from fishermen (n = 60) compared with control volunteers (n = 65). A systematic assessment was performed, and our results revealed increased Hg concentration in fishermen's blood. Erythrocyte functionality showed a 39 % decrease in O2 uptake. For peripheral blood mononuclear cells (PBMCs), ROS generation demonstrated an 87 and 116 % increase in O2 center dot- and H2O2 production, respectively, confirmed by fluorescence microscopy. Scanning electron microscopy showed increased roughness in the PBMCs membrane. Secondary oxidative stress markers revealed a reduction in the GSH/GSSG ratio and thiol content. MDA production increased by 89 %, while antioxidant enzyme activities showed a 159 and 22 % increase in SOD and CAT, respectively; otherwise, a depletion of 33 % in GPx. The metabolomic profile exhibited changes in essential amino acids for GSH formation, and energy pathways were modified. Finally, our data indicates that exposure to a polluted environment alters redox status, leading to compromised function and structure of blood cells.
C1 [Queiroz, Maiara I. C.; Sales, Marcos V. S.; Barros, Ellen dos Santos Silva; Ursulino, Jeferson S.; Aquino, Thiago M.; Santos, Josue Carinhanha C.; Leite, Ana Catarina R.] Univ Fed Alagoas UFAL, Inst Quim & Biotecnol, Maceio, Alagoas, Brazil.
   [D'Amato, Flavio O. S.; Rocha, Ueslen; Fonseca, Eduardo Jorge S.] Univ Fed Alagoas UFAL, Inst Fis, Maceio, Alagoas, Brazil.
   [Goncalves, Camilla M.; Borbely, Alexandre U.] Univ Fed Alagoas UFAL, Inst Ciencias Biol & Saude, Maceio, Alagoas, Brazil.
   [Bueno, Nassib B.] Univ Fed Alagoas UFAL, Fac Nutr, Maceio, Alagoas, Brazil.
   [Marinho, Chiara] Ctr Univ CESMAC, Maceio, Alagoas, Brazil.
   [Oliveira, Helena C. F.] Univ Estadual Campinas UNICAMP, Dept Biol Estrutural & Func, Inst Biol, Sao Paulo, Brazil.
C3 Universidade Federal de Alagoas; Universidade Federal de Alagoas;
   Universidade Federal de Alagoas; Universidade Federal de Alagoas;
   Universidade de Sao Paulo; Universidade Estadual de Campinas
RP Santos, JCC; Leite, ACR (corresponding author), Univ Fed Alagoas UFAL, Inst Quim & Biotecnol, Maceio, Alagoas, Brazil.
EM josue@iqb.ufal.br; ana.leite@iqb.ufal.br
RI Borbely, Alexandre/GRR-8137-2022; Queiroz, Maiara/KLC-1311-2024; Bueno,
   Nassib/P-8057-2018; Oliveira, Helena/M-5068-2013; aquino,
   thiago/B-5443-2017; Sales, Marcos/IAP-5466-2023; Leite, Ana
   Catarina/K-8340-2014
OI Leite, Ana Catarina/0000-0002-3426-3357; Sales,
   Marcos/0000-0002-5456-849X; Urban Borbely, Alexandre/0000-0001-6737-0901
FU Alagoas Research Foundation (FAPEAL) [60030.0000000461/2020]; Sao Paulo
   Research Foundation (FAPESP) [2017/17728-8, 2019/25321-0]
FX This research was funded by Alagoas Research Foundation (FAPEAL) , grant
   number 60030.0000000461/2020 (JCCS) and Sao Paulo Research Foundation
   (FAPESP) , grant numbers 2017/17728-8 and 2019/25321-0 (HCFO) .
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NR 108
TC 1
Z9 1
U1 3
U2 3
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0304-3894
EI 1873-3336
J9 J HAZARD MATER
JI J. Hazard. Mater.
PD JUL 15
PY 2025
VL 492
AR 138088
DI 10.1016/j.jhazmat.2025.138088
EA APR 2025
PG 13
WC Engineering, Environmental; Environmental Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering; Environmental Sciences & Ecology
GA 1DN3N
UT WOS:001462452300001
PM 40179776
DA 2025-06-11
ER

PT J
AU Somanah, J
   Aruoma, OI
   Gunness, TK
   Kowelssur, S
   Dambala, V
   Murad, F
   Googoolye, K
   Daus, D
   Indelicato, J
   Bourdon, E
   Bahorun, T
AF Somanah, Jhoti
   Aruoma, Okezie I.
   Gunness, Teeluck K.
   Kowelssur, Sudhir
   Dambala, Venkatesh
   Murad, Fatima
   Googoolye, Kreshna
   Daus, Diana
   Indelicato, Joseph
   Bourdon, Emmanuel
   Bahorun, Theeshan
TI Effects of a short term supplementation of a fermented papaya
   preparation on biomarkers of diabetes mellitus in a randomized Mauritian
   population
SO PREVENTIVE MEDICINE
LA English
DT Article
DE Neo-diabetics; Clinical trial; Fermented papaya preparation (FPP);
   Antioxidants; Biomarkers
ID C-REACTIVE PROTEIN; METABOLIC SYNDROME; CELLS
AB Objective. Clinical evidence and cellular models have shown an inverse relationship between the intakes of plant and fruit based diets and oxidative stress, suggesting the suitability of natural antioxidants in the management of diabetes mellitus and its complications.
   Method. A randomized controlled clinical trial was conducted at the Cardiac Centre, SSRN Hospital, Pamplemousses, (Mauritius) to determine the effect of a short term supplementation of a fermented papaya preparation (FPP (R)) on biomarkers of diabetes and antioxidant status in a multi-ethnical neo-diabetic population from November 2010 to March 2011.
   Result Supplementation of 6 g FPP (R)/day for a period of 14 weeks could improve the general health status of several organs targeted by oxidative stress during diabetes. When comparing experimental to control groups with independent samples t-test, C-reactive protein levels significantly decreased (P=0.018), LDL/HDL ratio was considerably changed (P=0.042), and uric acid levels were significantly improved (P=0.001). ANOVA results also validated the same findings with significant differences in C-reactive protein, LDL/HDL ratio, uric acid and in serum ferritin levels.
   Conclusion. FPP (R) may present a novel, economically feasible nutraceutical supplement for the management of diabetes and for those at risk for cardiovascular disease, neurological disease and other conditions worsened by overt inflammation and oxidative stress. (C) 2012 Elsevier Inc. All rights reserved.
C1 [Aruoma, Okezie I.] Amer Univ Hlth Sci, Sch Biomed Sci, Signal Hill, CA USA.
   [Aruoma, Okezie I.] Amer Univ Hlth Sci, Sch Pharm, Signal Hill, CA USA.
   [Somanah, Jhoti; Bahorun, Theeshan] Univ Mauritius, ANDI Ctr Excellence Biomed & Biomat Res, Reduit, Mauritius.
   [Somanah, Jhoti; Bahorun, Theeshan] Univ Mauritius, Dept Biosci, Reduit, Mauritius.
   [Gunness, Teeluck K.] SSRNH, Cardiac Ctr, Pamplemousses, Mauritius.
   [Dambala, Venkatesh] Apollo Bramwell Hosp, Dept Biochem, Moka, Mauritius.
   [Murad, Fatima] Apollo Bramwell Hosp, Ctr Clin Res & Educ, Moka, Mauritius.
   [Googoolye, Kreshna] Human Resource Dev Council, Ebene, Mauritius.
   [Daus, Diana; Indelicato, Joseph] Touro Coll Hlth Sci, Dept Occupat Therapy, Bay Shore, NY USA.
C3 University of Mauritius; University of Mauritius
RP Aruoma, OI (corresponding author), Amer Univ Hlth Sci, Sch Biomed Sci, Signal Hill, CA USA.
EM oaruoma@auhs.edu; tbahorun@uom.ac.mu
RI Aruoma, Okezie/AAF-7367-2021; Bourdon, Emmanuel/P-8455-2019
OI Somanah, Jhoti/0009-0006-5418-2999; Bourdon,
   Emmanuel/0000-0003-3731-150X
FU Mauritius Research Council; Osato Research Institute, Gifu, Japan
FX This research was supported by the Mauritius Research Council and Osato
   Research Institute, Gifu, Japan. The authors would like to thank the
   staff of the Cardiac Centre, SSRN Hospital (Pamplemousses) and the
   technicians of the biochemistry laboratory of Apollo Bramwell Hospital
   and BioHealth Ltd (Beau Bassin).
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NR 30
TC 30
Z9 32
U1 1
U2 21
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0091-7435
EI 1096-0260
J9 PREV MED
JI Prev. Med.
PD MAY 1
PY 2012
VL 54
SU 1
BP S90
EP S97
DI 10.1016/j.ypmed.2012.01.014
PG 8
WC Public, Environmental & Occupational Health; Medicine, General &
   Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health; General & Internal Medicine
GA 955ST
UT WOS:000305041900017
PM 22330753
DA 2025-06-11
ER

PT J
AU Lubitz, I
   Ricny, J
   Atrakchi-Baranes, D
   Shemesh, C
   Kravitz, E
   Liraz-Zaltsman, S
   Maksin-Matveev, A
   Cooper, I
   Leibowitz, A
   Uribarri, J
   Schmeidler, J
   Cai, WJ
   Kristofikova, Z
   Ripova, D
   LeRoith, D
   Schnaider-Beeri, M
AF Lubitz, Irit
   Ricny, Jan
   Atrakchi-Baranes, Dana
   Shemesh, Chen
   Kravitz, Efrat
   Liraz-Zaltsman, Sigal
   Maksin-Matveev, Anna
   Cooper, Itzik
   Leibowitz, Avshalom
   Uribarri, Jaime
   Schmeidler, James
   Cai, Weijing
   Kristofikova, Zdena
   Ripova, Daniela
   LeRoith, Derek
   Schnaider-Beeri, Michal
TI High dietary advanced glycation end products are associated with poorer
   spatial learning and accelerated A deposition in an Alzheimer mouse
   model
SO AGING CELL
LA English
DT Article
DE advanced glycation end product; Alzheimer's disease; A; blood-brain
   barrier; receptor for advanced glycation end product; Tg2576
ID BLOOD-BRAIN-BARRIER; OXIDATIVE STRESS; METABOLIC SYNDROME; COGNITIVE
   DECLINE; BETA; DISEASE; RAGE; GLYCOTOXINS; ACTIVATION; DEMENTIA
AB There is growing evidence of the involvement of advanced glycation end products (AGEs) in the pathogenesis of neurodegenerative processes including Alzheimer's disease (AD) and their function as a seed for the aggregation of A, a hallmark feature of AD. AGEs are formed endogenously and exogenously during heating and irradiation of foods. We here examined the effect of a diet high in AGEs in the context of an irradiated diet on memory, insoluble A(42), AGEs levels in hippocampus, on expression of the receptor for AGEs (RAGE), and on oxidative stress in the vasculature. We found that AD-like model mice on high-AGE diet due to irradiation had significantly poorer memory, higher hippocampal levels of insoluble A(42) and AGEs as well as higher levels of oxidative stress on vascular walls, compared to littermates fed an isocaloric diet. These differences were not due to weight gain. The data were further supported by the overexpression of RAGE, which binds to A(42) and regulates its transport across the blood-brain barrier, suggesting a mediating pathway. Because exposure to AGEs can be diminished, these insights provide an important simple noninvasive potential therapeutic strategy for alleviating a major lifestyle-linked disease epidemic.
C1 [Lubitz, Irit; Atrakchi-Baranes, Dana; Shemesh, Chen; Kravitz, Efrat; Liraz-Zaltsman, Sigal; Maksin-Matveev, Anna; Cooper, Itzik; Schnaider-Beeri, Michal] Joseph Sagol Neurosci Ctr Tel Hashomer, IL-52621 Ramat Gan, Israel.
   [Ricny, Jan; Kristofikova, Zdena; Ripova, Daniela] NIMH, Dept Biochem & Brain Pathophysiol, Topolova 748, Klecany 25067, Czech Republic.
   [Leibowitz, Avshalom] Chaim Sheba Med Ctr, Dept Internal Med D, IL-52621 Ramat Gan, Israel.
   [Leibowitz, Avshalom] Chaim Sheba Med Ctr, Hypertens Unit, IL-52621 Ramat Gan, Israel.
   [Uribarri, Jaime; Schmeidler, James; Cai, Weijing; Schnaider-Beeri, Michal] Mt Sinai Sch Med, Dept Psychiat, New York, NY 10029 USA.
   [LeRoith, Derek] Icahn Sch Med Mt Sinai, Dept Med, New York, NY 10029 USA.
C3 National Institute of Mental Health - Czech Republic; Chaim Sheba
   Medical Center; Chaim Sheba Medical Center; Icahn School of Medicine at
   Mount Sinai; Icahn School of Medicine at Mount Sinai
RP Lubitz, I (corresponding author), Joseph Sagol Neurosci Ctr, Sheba Med Ctr, IL-52621 Ramat Gan, Israel.
EM Irit.Lubitz@sheba.health.gov.il
RI Uribarri, Jaime/ADX-7655-2022; Lubitz, Irit/H-7588-2012; Ricny,
   Jan/V-1662-2018
OI Ricny, Jan/0000-0003-2625-057X; uribarri, jaime/0000-0001-9826-1134;
   cooper, itzik/0000-0003-0723-5542; Liraz Zaltsman,
   Sigal/0000-0001-9519-2989
FU Ministry of Science and Technology, Israel; Ministry of Education Youth
   and Sports, Czech Republic
FX This research was supported by the Ministry of Science and Technology,
   Israel & the Ministry of Education Youth and Sports, Czech Republic.
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NR 44
TC 77
Z9 82
U1 0
U2 37
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1474-9718
EI 1474-9726
J9 AGING CELL
JI Aging Cell
PD APR
PY 2016
VL 15
IS 2
BP 309
EP 316
DI 10.1111/acel.12436
PG 8
WC Cell Biology; Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Geriatrics & Gerontology
GA DH6DF
UT WOS:000372880500012
PM 26781037
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Puddu, P
   Puddu, GM
   Cravero, E
   Vizioli, L
   Muscari, A
AF Puddu, Paolo
   Puddu, Giovanni M.
   Cravero, Eleonora
   Vizioli, Luca
   Muscari, Antonio
TI The relationships among hyperuricemia, endothelial dysfunction, and
   cardiovascular diseases: Molecular mechanisms and clinical implications
SO JOURNAL OF CARDIOLOGY
LA English
DT Review
DE Allopurinol; Atherosclerosis; Oxidative stress; Risk factors; Uric acid;
   Xanthine oxidoreductase
ID SERUM URIC-ACID; CORONARY-HEART-DISEASE; XANTHINE-OXIDASE INHIBITION;
   INTIMA-MEDIA THICKNESS; NITRIC-OXIDE; OXIDATIVE STRESS; CAROTID
   ATHEROSCLEROSIS; ESSENTIAL-HYPERTENSION; METABOLIC SYNDROME; RISK-FACTOR
AB Uric acid is the end product of purine metabolism. Its immediate precursor, xanthine, is converted to uric acid by an enzymatic reaction involving xanthine oxidoreductase. Uric acid has been formerly considered a major antioxidant in human plasma with possible beneficial anti-atherosclerotic effects. In contrast, studies in the past two decades have reported associations between elevated serum uric acid levels and cardiovascular events, suggesting a potential role for uric acid as a risk factor for atherosclerosis and related diseases. In this paper, the molecular pattern of uric acid formation, its possible deleterious effects, as well as the involvement of xanthine oxidoreductase in reactive oxygen species generation are critically discussed. Reactive oxygen species contribute to vascular oxidative stress and endothelial dysfunction, which are associated with the risk of atherosclerosis. Recent studies have renewed attention to the xanthine oxidoreductase system, since xanthine oxidoreductase inhibitors, such as allopurinol and oxypurinol, would be capable of preventing atherosclerosis progression by reducing endothelial dysfunction. Also, beneficial effects could be obtained in patients with congestive heart failure. The simultaneous reduction in uric acid levels might contribute to these effects, or be a mere epiphenomenon of the drug action. The molecular mechanisms involved are discussed. (C) 2012 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved.
C1 Univ Bologna, Dept Internal Med Aging & Nephrol Dis, I-40138 Bologna, Italy.
   [Muscari, Antonio] Univ Bologna, S Orsola M Malpighi Hosp, Stroke Unit, Dept Internal Med Aging & Nephrol Dis, I-40138 Bologna, Italy.
C3 University of Bologna; University of Bologna; IRCCS Azienda
   Ospedaliero-Universitaria di Bologna
RP Muscari, A (corresponding author), Univ Bologna, S Orsola M Malpighi Hosp, Stroke Unit, Dept Internal Med Aging & Nephrol Dis, Via Albertoni 15, I-40138 Bologna, Italy.
EM antonio.muscari@unibo.it
RI Vizioli, Luca/GMW-8549-2022
OI VIZIOLI, LUCA/0000-0003-2278-2181
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NR 112
TC 196
Z9 221
U1 1
U2 54
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0914-5087
EI 1876-4738
J9 J CARDIOL
JI J. Cardiol.
PD MAY
PY 2012
VL 59
IS 3
BP 235
EP 242
DI 10.1016/j.jjcc.2012.01.013
PG 8
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 961CH
UT WOS:000305441000001
PM 22398104
OA Bronze
DA 2025-06-11
ER

PT J
AU Rosa, PC
   Courtes, AA
   Gonçalves, DF
   Hartmann, DD
   Stefanello, ST
   Zamberlan, DC
   Berté, JK
   dos Santos, DL
   Soares, FAA
   Barcelos, RP
AF Rosa, Pamela Carvalhoda
   Courtes, Aline Alves
   Goncalves, Debora Farina
   Hartmann, Diane Duarte
   Stefanello, Silvio Terra
   Zamberlan, Daniele Coradini
   Berte, Jessica Karine
   dos Santos, Daniela Lopes
   Antunes Soares, Felix Alexandre
   Barcelos, Romulo Pillon
TI Moderate-intensity functional training improves mitochondrial capability
   and redox state in peripheral blood mononuclear cells of metabolic
   syndrome women
SO SPORT SCIENCES FOR HEALTH
LA English
DT Article
DE Exercise; Metabolism; Oxidative stress; Chronic disease
ID EXERCISE; ADAPTATION; INFLAMMATION; EXPRESSION; BIOLOGY; MUSCLE; MODEL
AB PurposeEvidence exists that both oxidative stress and mitochondrial dysfunction play a pivotal role in the metabolic syndrome (MetS), and also, likely then extent for peripheral blood mononuclear cells (PBMCs). Despite knowledge of the beneficial effects of physical exercises, studies about the modality of functional training (FT) on remodeling in mitochondrial metabolism and redox states, especially at PBMCs from patients with MetS, are rare and still controversial. Thus, this study intends to examine how FT can influence PBMCs metabolism, mitochondrial capability, and redox state in women with MetS.MethodsUntrained women over 45-years-old were classified as having three or more pre-defined components of MetS. The participants (n=10) completed three training sessions, and each session lasted about 60-min sessions per week for 12-weeks. We performed baseline and posttest measures in PBMCs, which were obtained before training (baseline) and 72 h after the end of the training protocol to avoid acute exercise effects. Adherence was defined as completing 85% of exercise sessions.ResultsFT produced an increase of 96.6% in lactate dehydrogenase activity (p=0.002) of PBMCs, while citrate synthase activity (p=0.49) remained unaltered. The training protocol also demonstrated an increase of 39.7% DCF levels (p=0.0039) exercise-induced formation, as well as antioxidant system adaptation (CAT activity) (78.5%; p=0.005). Electron transfer capability from CI (112.7%; p=0.002), CII (89.1%; p=0.046) and CIII (26.8%; p=0.046) increased after training, however, no changes in CIV (p=0.72) were observed. No significant changes in BMI or body weight were found, but the training protocol resulted in a significant increase in VO(2)max of 18% at posttest (p=0.0035).ConclusionWe provided novel evidence that a 12-week FT program modifies mitochondrial capability and redox state in PBMCs, it seems to be some extent women's aerobic fitness improvement. Therefore, our data suggest that PBMCs could be used to detect and assess changes in cellular profiles from unhealthy patients, as well as biomarkers source for physical exercise control and quality.
C1 [Rosa, Pamela Carvalhoda; Courtes, Aline Alves; Goncalves, Debora Farina; Hartmann, Diane Duarte; Stefanello, Silvio Terra; Zamberlan, Daniele Coradini; Antunes Soares, Felix Alexandre; Barcelos, Romulo Pillon] Univ Fed Santa Maria, Programa Posgrad Ciencias Biol Bioquim Toxicol, Ctr Ciencias Nat & Exatas, Santa Maria, RS, Brazil.
   [Berte, Jessica Karine; dos Santos, Daniela Lopes] Univ Fed Santa Maria, Dept Metodos & Tecn Desport, Ctr Educ Fis & Desporto, Santa Maria, RS, Brazil.
   [Barcelos, Romulo Pillon] Univ Passo Fundo, Programa Posgrad Bioexpt, Inst Ciencias Biol, Passo Fundo, RS, Brazil.
C3 Universidade Federal de Santa Maria (UFSM); Universidade Federal de
   Santa Maria (UFSM); Universidade de Passo Fundo
RP Barcelos, RP (corresponding author), Univ Fed Santa Maria, Programa Posgrad Ciencias Biol Bioquim Toxicol, Ctr Ciencias Nat & Exatas, Santa Maria, RS, Brazil.; Barcelos, RP (corresponding author), Univ Passo Fundo, Programa Posgrad Bioexpt, Inst Ciencias Biol, Passo Fundo, RS, Brazil.
EM romulo1604@hotmail.com
RI dos Santos, Daniela/AAU-2310-2021; Hartmann, Diane/AAC-8307-2020;
   Soares, Félix/AAE-6251-2020; Stefanello, Silvio Terra/I-3106-2014;
   Soares, Felix/K-7611-2012; Barcelos, Romulo/J-8231-2015
OI Santos, Daniela/0000-0002-1782-1337; Stefanello, Silvio
   Terra/0000-0002-6673-6550; Farina Goncalves, Debora/0000-0003-2356-2922;
   Soares, Felix/0000-0002-6453-7902; da Rosa, Pamela
   Carvalho/0000-0002-4827-7063; Barcelos, Romulo/0000-0002-6366-6366
FU Brazilian National Council of Technological and Scientific Development
   (CNPq); ''Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior"
   (CAPES); Programa de Apoio a Nucleos Emergentes, supported this work
   (PRONEM) MCTI/CNPq [472669/2011-7, 475896/2012-2]; Coordenacao de
   Aperfeicoamento de Pessoal de Nivel Superior CAPES/PROEX
   [88882.182174/2018-01]
FX Brazilian National Council of Technological and Scientific Development
   (CNPq), "Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior"
   (CAPES) " Programa de Apoio a Nucleos Emergentes, supported this work
   (PRONEM) MCTI/CNPq [Grant Number 472669/2011-7, 475896/2012-2], and the
   Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior CAPES/PROEX
   [process number: 88882.182174/2018-01].
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NR 50
TC 1
Z9 1
U1 1
U2 3
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 1824-7490
EI 1825-1234
J9 SPORT SCI HLTH
JI Sport Sci. Health
PD MAR
PY 2021
VL 17
IS 1
BP 91
EP 101
DI 10.1007/s11332-020-00657-z
PG 11
WC Sport Sciences
WE Emerging Sources Citation Index (ESCI)
SC Sport Sciences
GA TM8SS
UT WOS:000675816500006
DA 2025-06-11
ER

PT J
AU Liu, YW
   Ma, CF
   Lv, L
   Li, PP
   Ma, CX
   He, SL
   Zeng, JB
   Ping, F
   Zhang, HB
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   Li, YX
AF Liu, Yiwen
   Ma, Chifa
   Lv, Lu
   Li, Pingping
   Ma, Chunxiao
   He, Shuli
   Zeng, Jingbo
   Ping, Fan
   Zhang, Huabing
   Li, Wei
   Xu, Lingling
   Li, Yuxiu
TI Relationship between Decreased Serum Superoxide Dismutase Activity and
   Metabolic Syndrome: Synergistic Mediating Role of Insulin Resistance and
   β-Cell Dysfunction
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Article
ID DNA COPY NUMBER; OXIDATIVE STRESS; TELOMERE LENGTH; GLUCOSE;
   ASSOCIATIONS; INFLAMMATION; SENSITIVITY; PROGRESSION; PREVALENCE
AB The interplays of cellular aging and oxidative stress (OS) markers form a complex network, which has been reported to be interrelated with numerous age-related and metabolic diseases, including metabolic syndrome (MS). However, given the multifactorial mechanisms of MS, several important confounders such as dietary factors and the reciprocal effect among these markers have not been considered and adjusted in previous investigations regarding the associations of cellular aging and OS markers with MS and its related metabolic abnormalities. To explicate this, we conducted a cross-sectional study among 533 Chinese adults. All the participants underwent a 75 g oral glucose tolerance test. Dietary data were collected via a 24-hour dietary recall and subsequently analyzed by a registered dietitian using nutrition calculation software. Clinical diagnosis of MS was made according to the revised National Cholesterol Education Program Adult Treatment Panel III criteria (2004) with waist circumference cutoff modified for an Asian population. The leukocyte telomere length, mitochondrial DNA copy number, 8-hydroxy-2-deoxyguanosine, superoxide dismutase (SOD) activity, and glutathione reductase were examined. SOD activity was significantly decreased in MS subjects (62.06 +/- 16.89 U/mL vs. 56.25 +/- 22.61 U/mL, P = 0.001) and exhibited a descending trend across sequential increase of MS component number (P for trend = 0.031). SOD activity is modestly correlated with glucose indicators and insulin sensitivity and beta-cell function indices and was independently and negatively correlated with the level of triglyceride. An independent association between SOD activity and MS was observed after adjusting for metabolic indicators, dietary factors, cellular aging, and OS markers, as well as insulin sensitivity and beta-cell function indices. However, the statistical significance of the association between SOD activity and MS was attenuated after adjusting for the Matsuda insulin sensitivity index (ISIM) and insulin secretion-sensitivity index-2 (ISSI-2), suggesting a possible mediating effect. Therefore, we conducted a mediation model analysis, which showed that decreased ISIM and ISSI-2 partially and synergistically mediated the contribution of decreased SOD activity to MS. In conclusion, decreased SOD activity is an independent predictor for increased risk of MS, and insulin resistance and beta-cell dysfunction partially mediate the relationship between decreased SOD activity and MS.
C1 [Liu, Yiwen; Ma, Chifa; Lv, Lu; Ping, Fan; Zhang, Huabing; Li, Wei; Xu, Lingling; Li, Yuxiu] Chinese Acad Med Sci, Peking Union Med Coll Hosp, Peking Union Med Coll, Dept Endocrinol,Key Lab Endocrinol,Minist Hlth, Beijing 100730, Peoples R China.
   [Li, Pingping; Ma, Chunxiao] Inst Mat Med Sci, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China.
   [Li, Pingping; Ma, Chunxiao] Peking Union Med Coll, Beijing 100050, Peoples R China.
   [Li, Pingping; Ma, Chunxiao] Chinese Acad Med Sci, Diabet Res Ctr, Beijing 100050, Peoples R China.
   [He, Shuli] Peking Union Med Coll Hosp, Dept Nutr, Beijing 100730, Peoples R China.
   [Zeng, Jingbo] Capital Med Univ, Fuxing Hosp, Clin Med Coll 8, Dept Endocrinol, Beijing 100038, Peoples R China.
C3 Chinese Academy of Medical Sciences - Peking Union Medical College;
   Peking Union Medical College Hospital; Peking Union Medical College;
   Chinese Academy of Medical Sciences - Peking Union Medical College;
   Peking Union Medical College; Chinese Academy of Medical Sciences -
   Peking Union Medical College; Chinese Academy of Medical Sciences -
   Peking Union Medical College; Peking Union Medical College Hospital;
   Capital Medical University
RP Li, YX (corresponding author), Chinese Acad Med Sci, Peking Union Med Coll Hosp, Peking Union Med Coll, Dept Endocrinol,Key Lab Endocrinol,Minist Hlth, Beijing 100730, Peoples R China.
EM liyuxiu@medmail.com.cn
RI Li, Yuxiu/AAE-1202-2022; Li, Wei/JDD-4293-2023; Zhang,
   Huabing/ABD-6216-2020; Xu, Lingling/G-8708-2016; Li,
   pingping/JPW-9278-2023
OI Li, Wei/0000-0002-3332-1287; Liu, Yiwen/0000-0002-7982-7996
FU CAMS Innovation Fund for Medical Sciences (CIFMS) [CIFMS2016-I2M-4-001];
   Non-profit Central Research Institute Fund of Chinese Academy of Medical
   Sciences [2019PT320007]
FX This work was supported by the CAMS Innovation Fund for Medical Sciences
   (CIFMS) (grant number CIFMS2016-I2M-4-001) and the Non-profit Central
   Research Institute Fund of Chinese Academy of Medical Sciences (grant
   number 2019PT320007).
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NR 41
TC 11
Z9 11
U1 3
U2 9
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PD JUN 13
PY 2020
VL 2020
AR 5384909
DI 10.1155/2020/5384909
PG 10
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA ME3ZQ
UT WOS:000544597400001
PM 32617139
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Plata, MD
   Williams, L
   Seki, Y
   Hartil, K
   Kaur, H
   Lin, CL
   Fiallo, A
   Glenn, AS
   Katz, EB
   Fuloria, M
   Charron, MJ
   Vuguin, PM
AF Plata, Maria del Mar
   Williams, Lyda
   Seki, Yoshinori
   Hartil, Kirsten
   Kaur, Harpreet
   Lin, Chia-Lei
   Fiallo, Ariana
   Glenn, Alan S.
   Katz, Ellen B.
   Fuloria, Mamta
   Charron, Maureen J.
   Vuguin, Patricia M.
TI Critical periods of increased fetal vulnerability to a maternal high fat
   diet
SO REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
LA English
DT Article
ID INTRAUTERINE GROWTH-RETARDATION; GESTATIONAL DIABETES-MELLITUS; EXPOSURE
   IN-UTERO; INSULIN-RESISTANCE; METABOLIC SYNDROME; ADIPONECTIN LEVELS;
   GENE-EXPRESSION; INDUCED OBESITY; ADIPOSE-TISSUE; HUMAN PLACENTA
AB Background: Fetal adaptations to high fat (HF) diet in utero (IU) that may predispose to Metabolic Syndrome (MetS) in adulthood include changes in fetal hepatic gene expression. Studies were performed to determine whether maternal exposure to HF diet at different stages during pregnancy had different effects on the fetus, including hepatic gene expression.
   Methods: Female wild type mice were fed either a HF or breeding chow (C) for 2 wks prior to mating. The experimental groups were composed of embryonic day (e) 18.5 fetuses obtained from WT female mice that were fed HF (HF, 35.5% fat) or breeding chow (C, 9.5% fat) for 2 wk before mating until e9.5 of pregnancy (periconception-midpregnancy). At e9.5 dams were switched to the opposite diet (C-HF or HF-C).
   Results: Exposure to HF diet throughout pregnancy reduced maternal weight gain compared to C diet (p < 0.02 HF vs. C). HF-C dams had significantly decreased adiponectin levels and litter size when compared to C-HF (p < 0.02 HF-C vs C-HF). Independent of the timing of exposure to HF, fetal weight and length were significantly decreased when compared to C diet (HF, C-HF and HF-C vs. C p < 0.02). HF diet during the second half of pregnancy increased expression of genes in the fetal liver associated with fetal growth (C-HF vs C p < 0.001), glucose production (C-HF vs C p < 0.04), oxidative stress and inflammation (C-HF vs C p < 0.01) compared to C diet.
   Conclusions: This model defines that there are critical periods during gestation in which the fetus is actively shaped by the environment. Early exposure to a HF diet determines litter size while exposure to HF during the second half of pregnancy leads to dysregulation of expression of key genes responsible for fetal growth, hepatic glucose production and oxidative stress. These findings underscore the importance of future studies designed to clarify how these critical periods may influence future risk of developing MetS later in life.
C1 [Plata, Maria del Mar; Kaur, Harpreet; Fuloria, Mamta; Vuguin, Patricia M.] Albert Einstein Coll Med, Dept Pediat, Bronx, NY 10461 USA.
   [Williams, Lyda; Seki, Yoshinori; Hartil, Kirsten; Lin, Chia-Lei; Fiallo, Ariana; Glenn, Alan S.; Katz, Ellen B.; Charron, Maureen J.] Albert Einstein Coll Med, Dept Biochem, Bronx, NY 10461 USA.
   [Charron, Maureen J.] Albert Einstein Coll Med, Dept Med, Bronx, NY 10461 USA.
   [Charron, Maureen J.] Albert Einstein Coll Med, Dept Obstet & Gynecol, Bronx, NY 10461 USA.
   [Vuguin, Patricia M.] Cohen Childrens Med Ctr, Hofstra Sch Med, Lake Success, NY 11402 USA.
C3 Yeshiva University; Montefiore Medical Center; Albert Einstein College
   of Medicine; Yeshiva University; Montefiore Medical Center; Albert
   Einstein College of Medicine; Montefiore Medical Center; Albert Einstein
   College of Medicine; Yeshiva University; Yeshiva University; Montefiore
   Medical Center; Albert Einstein College of Medicine; Northwell Health;
   North Shore University Hospital; Steven & Alexandra Cohen Children's
   Medical Center of New York; Hofstra University
RP Charron, MJ (corresponding author), Albert Einstein Coll Med, Dept Biochem, Bronx, NY 10461 USA.
EM maureen.charron@einstein.yu.edu; pvuguin@nshs.edu
RI Kaur, Harpreet/HTN-0358-2023
OI vuguin, patricia/0000-0002-4982-0400
FU National Institute of Health [R21 DK081194, K08-HD042172]; American
   Diabetes Association [1-13-CE-06]; Mentor based postdoctoral fellowship;
   Diabetes Center of Albert Einstein College of Medicine; Liver Research
   Center of Albert Einstein College of Medicine; Training Center of Albert
   Einstein College of Medicine; Cancer Center of Albert Einstein College
   of Medicine
FX We are grateful to Mr. Carlos Vargas, Ms. Amy Sorvino and Ms. Goutami
   Sayal for their technical expertise. This study was supported by grants
   from the National Institute of Health R21 DK081194 (to MJC and PV) and
   K08-HD042172 (PV), and the American Diabetes Association 1-13-CE-06 and
   Mentor based postdoctoral fellowship (MJC). Additional support was
   generously provided by the Diabetes and Liver Research and Training and
   Cancer Centers of Albert Einstein College of Medicine.
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NR 61
TC 18
Z9 18
U1 0
U2 9
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1477-7827
J9 REPROD BIOL ENDOCRIN
JI Reprod. Biol. Endocrinol.
PD AUG 18
PY 2014
VL 12
BP 1
EP 11
DI 10.1186/1477-7827-12-80
PG 11
WC Endocrinology & Metabolism; Reproductive Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Reproductive Biology
GA AO7MF
UT WOS:000341536600001
PM 25135621
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Calderon-Hernández, MF
   Altamirano-Bustamante, NF
   Revilla-Monsalve, C
   Mosquera-Andrade, MB
   Altamirano-Bustamante, MM
AF Calderon-Hernandez, Maria F.
   Altamirano-Bustamante, Nelly F.
   Revilla-Monsalve, Cristina
   Mosquera-Andrade, Maria Belen
   Altamirano-Bustamante, Myriam M.
TI What can we learn from β-cell failure biomarker application in diabetes
   in childhood? A systematic review
SO WORLD JOURNAL OF DIABETES
LA English
DT Review
DE Biomarker; beta-cell failure; Children; Adolescents; Diabetes mellitus;
   Metabolic syndrome
ID ISLET AMYLOID POLYPEPTIDE; INSULIN-RESISTANCE; OBESE CHILDREN; MEMBRANE
   DISRUPTION; TYPE-2; IAPP; MELLITUS; ONSET; RISK; DYSFUNCTION
AB BACKGROUND The prevalence of diabetes as a catastrophic disease in childhood is growing in the world. The search for novel biomarkers of beta-cell failure has been an elusive task because it requires several clinical and biochemical measurements in order to integrate the risk of metabolic syndrome. AIM To determine which biomarkers are currently used to identify beta-cell failure among children and adolescents with high risk factors for diabetes mellitus. METHODS This systematic review was carried out using a modified version of the PICO protocol (Participants/Intervention/Comparison/Outcome). Once our research question was established, terms were individually researched on three different databases (PubMed, BIREME and Web of Science). The total articles obtained underwent a selection process from which the 78 most relevant articles were retrieved to undergo further analysis. They were assessed individually according to quality criteria. RESULTS First, we made the classification of the beta-cell-failure biomarkers by the target tissue and the evolution of the disease, separating the biomarkers in relation to the types of diabetes. Second, we demonstrated that most biomarkers currently used as early signs of beta-cell failure are those that concern local or systemic inflammation processes and oxidative stress as well as those related to endothelial dysfunction processes. Third, we explored the novelties of diabetes as a protein conformational disease and the novel biomarker called real human islet amyloid polypeptide amyloid oligomers. Finally, we ended with a discussion about the best practice of validation and individual control of using different types of biomarkers in type 1 and type 2 diabetes in order to assess the role they play in the progress of diabetes in childhood. CONCLUSION This review makes widely evident that most biomarkers currently used as early signs of beta-cell failure are those that concern local or systemic inflammation processes and oxidative stress as well as those related to endothelial dysfunction processes. Landing in the clinical practice we propose that real human islet amyloid polypeptide amyloid oligomers is good for identifying patients with beta-cell damage and potentially could substitute many biomarkers.</p>
C1 [Calderon-Hernandez, Maria F.; Revilla-Monsalve, Cristina; Altamirano-Bustamante, Myriam M.] IMSS, Unidad Invest Enfermedades Metab, Ctr Med Nacl Siglo XXI, Ave Cuauhtemoc 330, Mexico City 06720, DF, Mexico.
   [Altamirano-Bustamante, Nelly F.; Mosquera-Andrade, Maria Belen] Inst Nacl Pediat, Dept Endocrinol, Mexico City 04530, DF, Mexico.
C3 Instituto Mexicano del Seguro Social
RP Altamirano-Bustamante, MM (corresponding author), IMSS, Unidad Invest Enfermedades Metab, Ctr Med Nacl Siglo XXI, Ave Cuauhtemoc 330, Mexico City 06720, DF, Mexico.
EM myriamab@unam.mx
RI Revilla-Monsalve, Cristina/ABG-6663-2021; Altamirano,
   Myriam/GPW-5376-2022
FU Mexico's National Council of Science and Technology (CONACYT)
   [SALUD-2010C02-151942]; Institute of Science and Technology of Mexico
   City
FX Supported by Mexico's National Council of Science and Technology
   (CONACYT), No. SALUD-2010C02-151942; and Institute of Science and
   Technology of Mexico City.
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NR 85
TC 0
Z9 0
U1 0
U2 5
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 7041 Koll Center Parkway, Suite 160, PLEASANTON, CA, UNITED STATES
EI 1948-9358
J9 WORLD J DIABETES
JI World J. Diabetes
PD AUG 15
PY 2021
VL 12
IS 8
BP 1325
EP 1362
DI 10.4239/wjd.v12.i8.1325
PG 38
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA UQ7ON
UT WOS:000696250300015
PM 34512897
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Di Segni, C
   Silvestrini, A
   Fato, R
   Bergamini, C
   Guidi, F
   Raimondo, S
   Meucci, E
   Romualdi, D
   Apa, R
   Lanzone, A
   Mancini, A
AF Di Segni, Chantal
   Silvestrini, Andrea
   Fato, Romana
   Bergamini, Christian
   Guidi, Francesco
   Raimondo, Sebastiano
   Meucci, Elisabetta
   Romualdi, Daniela
   Apa, Rosanna
   Lanzone, Antonio
   Mancini, Antonio
TI Plasmatic and Intracellular Markers of Oxidative Stress in Normal Weight
   and Obese Patients with Polycystic Ovary Syndrome
SO EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
LA English
DT Article
DE malondialdehyde; coenzymeQ(10); hyperandrogenism; antioxidants;
   metabolic syndrome
ID TOTAL ANTIOXIDANT CAPACITY; OMENTAL ADIPOSE-TISSUE; INSULIN-RESISTANCE;
   METABOLIC SYNDROME; PROTEOMIC ANALYSIS; SYNDROME PCOS; COENZYME-Q;
   WOMEN; PREVALENCE; MITOCHONDRIA
AB Introduction Insulin resistance (IR) is associated with polycystic ovary syndrome (PCOS). Oxidative stress (OS) is, in turn, related to IR. Studies in PCOS evidenced an increase in OS markers, but they are mainly performed in obese patients, while the complex picture of normal weight PCOS is still -poorly investigated.
   Matherials and Methods To investigate OS in PCOS and relationship with hormonal and metabolic picture, we performed a case-control study in 2 PCOS groups: normal weight (N-PCOS, n = 21, age 18-25 ys, mean +/- SEM BMI 20.7 +/- 0.2 kg/m(2)) and obese (OB-PCOS, n = 15, 20-30 ys, BMI 32.8 +/- 1.1), compared with control groups matched for BMI: normal (N-C, n = 10, 20-30 ys, BMI 21.6 +/- 0.9) and obese (OB-C, n = 20, 21-31ys, BMI 36.8 +/- 1.0). Malondialdehyde (MDA) in blood plasma and peripheral mononuclear cells, obtained by density-gradient centrifugation, was assayed spectrophotometrically by TBARS assay. CoenzymeQ(10) (CoQ(10)) in plasma and cells was assayed by HPLC. Plasma Total Antioxidant Capacity (TAC) was also measured by spectrophotometric method.
   Results PCOS patients exhibited higher Testosterone levels than controls, but OB-PCOS had highest HOMA (Homeostasis Model Assessment) index, suggesting marked insulin resistance. Despite plasma MDA levels were not significantly different (N-PCOS 3380 +/- 346.94 vs. N-C 7 120 +/- 541.66; OB-PCOS 5 517.5 +/- 853.9 vs. OB. 3 939.66 +/- 311.2 pmol/ml), intracellular MDA levels were significantly higher in N-PCOS than controls (mean 3 259 +/- 821.5 vs. 458 +/- 43.2 pmol/10(6)/cells) and higher than OB-PCOS, although not significantly (1363.1 +/- 412.8 pmol/10(6)/cells). Intracellular CoenzymeQ(10) was higher in N-PCOS than in N-C, but the highest levels were found in OB-C.
   Conclusions Our data, while confirming the presence of OS in obese PCOS patients in agreement with literature, suggest that OS could be present also in normal weight PCOS, but it can be revealed in tissue rather than in plasma. The relationship with metabolic status remains to be established, but could be a physiopathological basis for antioxidant treatment in such patients.
C1 [Di Segni, Chantal; Raimondo, Sebastiano; Mancini, Antonio] Univ Cattolica Sacro Cuore, Operat Unit Endocrinol, Dept Internal Med, Largo A Gemelli 8, Rome, Italy.
   [Silvestrini, Andrea; Meucci, Elisabetta] Univ Cattolica Sacro Cuore, Inst Biochem & Clin Biochem, Largo F Vito 1, Rome, Italy.
   [Fato, Romana] Univ Bologna, Dept Pharmacol & Biotechnol FaBiT, Via S Donato 15, Bologna, Italy.
   [Bergamini, Christian] Univ Bologna, CIRI HST, Via Tolara Sopra, Bologna, Italy.
   [Guidi, Francesco; Romualdi, Daniela; Apa, Rosanna; Lanzone, Antonio] Univ Cattolica Sacro Cuore, Dept Obstet & Gynecol, Largo A Gemelli 8, Rome, Italy.
C3 Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli;
   Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli;
   University of Bologna; University of Bologna; Catholic University of the
   Sacred Heart; IRCCS Policlinico Gemelli
RP Mancini, A (corresponding author), Catholic Univ, Operat Unit Endocrinol, Dept Internal Med, Largo A Gemelli 8, I-00168 Rome, Italy.; Silvestrini, A (corresponding author), Catholic Univ, Inst Biochem & Clin Biochem, Rome, Italy.
EM andrea.silvestrini@unicatt.it; mancini.giac@mclink.it
RI Guidi, Francesco/AAS-9209-2021; Silvestrini, Andrea/B-3410-2009
OI APA, Rosanna/0000-0003-0143-9114; Silvestrini,
   Andrea/0000-0002-2005-3746; LANZONE, Antonio/0000-0003-4119-414X
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NR 51
TC 15
Z9 15
U1 0
U2 4
PU JOHANN AMBROSIUS BARTH VERLAG MEDIZINVERLAGE HEIDELBERG GMBH
PI STUTTGART
PA RUEDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0947-7349
EI 1439-3646
J9 EXP CLIN ENDOCR DIAB
JI Exp. Clin. Endocrinol. Diabet.
PD SEP
PY 2017
VL 125
IS 8
BP 506
EP 513
DI 10.1055/s-0043-111241
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA FH5GF
UT WOS:000411192400002
PM 28675914
DA 2025-06-11
ER

PT J
AU Yildiz, F
   Lebaron, TW
   Alwazeer, D
AF Yildiz, Fatmanur
   Lebaron, Tyler W.
   Alwazeer, Duried
TI A comprehensive review of molecular hydrogen as a novel nutrition
   therapy in relieving oxidative stress and diseases: Mechanisms and
   perspectives
SO BIOCHEMISTRY AND BIOPHYSICS REPORTS
LA English
DT Review
DE Molecular hydrogen; Nutritional therapy; Diseases; Free radicals;
   Oxidative stress
ID RICH WATER; METABOLIC SYNDROME; BODY-COMPOSITION; ANTIOXIDANT; SALINE;
   GAS; IMPROVEMENT; IMPAIRMENTS; PROFILES; MEDICINE
AB Oxidative stress is responsible for the pathogenesis of many diseases, and antioxidants are commonly included in their treatment protocols. Over the past two decades, numerous biomedical reports have revealed the therapeutic benefits of molecular hydrogen (H2) in relieving oxidation-related diseases. H2 has been found to have selective antioxidant properties against the most dangerous oxidants (hydroxyl radicals and peroxynitrite). H2 demonstrates numerous biologically therapeutic properties, including anti-inflammatory, antioxidant, anti-cancer, antistress, anti-apoptotic, anti-allergic effects, signaling molecule functions, regulation of redox balance, modulation of antioxidant enzyme gene expression, improvement of blood vessel function, down-regulation of proinflammatory cytokines, stimulation of energy metabolism, and protection of the nervous system. Experimental and clinical studies have shown the potential use of hydrogen nutrition therapy for ameliorating various diseases, including cardiovascular, respiratory, and metabolic disorders, as well as obesity, gastrointestinal disorders, and brain and nervous system disorders. The administration methods of hydrogen include inhalation, hydrogen-rich water, hydrogen-rich saline, hydrogen-rich eye drops, and hydrogen-rich bathing. Hydrogen nutritional therapy can be applied to different diseases, and it offers a natural alternative to chemical and radiation therapies. This review covers the different administration methods and the latest experimental and clinical research on the potential applications of H2 in nutritional therapy for different diseases.
C1 [Yildiz, Fatmanur; Alwazeer, Duried] Igdir Univ, Res Ctr Redox Applicat Foods RCRAF, TR-76000 Igdir, Turkiye.
   [Yildiz, Fatmanur; Alwazeer, Duried] Igdir Univ, Innovat Food Technol Dev Applicat & Res Ctr, TR-76000 Igdir, Turkiye.
   [Lebaron, Tyler W.] Southern Utah Univ, Dept Kinesiol & Outdoor Recreat, Cedar City, UT 84720 USA.
   [Lebaron, Tyler W.] Mol Hydrogen Inst, Cedar City, UT 84721 USA.
   [Alwazeer, Duried] Igdir Univ, Fac Hlth Sci, Dept Nutr & Dietet, TR-76100 Igdir, Turkiye.
C3 Igdir University; Igdir University; Utah System of Higher Education;
   Southern Utah University; Igdir University
RP Alwazeer, D (corresponding author), Igdir Univ, Innovat Food Technol Dev Applicat & Res Ctr, TR-76000 Igdir, Turkiye.
EM tylerlebaron@suu.edu; duried.alwazeer@igdir.edu.tr
RI LeBaron, Tyler/GLT-7071-2022; YILDIZ, Fatmanur/HPG-4818-2023; Alwazeer,
   Duried/G-2589-2015
OI Alwazeer, Duried/0000-0002-2291-1628
FU Igdir University Scientific Research Projects Coordination Unit
   [YIbull;P1023Ibull;02]
FX This research was supported by Igdir University Scientific Research
   Projects Coordination Unit with project ID YI<SUP>center
   dot</SUP>P1023I<SUP>center dot</SUP>02.
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NR 102
TC 0
Z9 0
U1 13
U2 13
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2405-5808
J9 BIOCHEM BIOPHYS REP
JI Biochem. Biophys. Rep.
PD MAR
PY 2025
VL 41
AR 101933
DI 10.1016/j.bbrep.2025.101933
EA JAN 2025
PG 10
WC Biochemistry & Molecular Biology
WE Emerging Sources Citation Index (ESCI)
SC Biochemistry & Molecular Biology
GA U4Z0Q
UT WOS:001411882800001
PM 39911528
DA 2025-06-11
ER

PT J
AU Beyazit, F
   Yilmaz, N
   Balci, O
   Adam, M
   Yaman, ST
AF Beyazit, Fatma
   Yilmaz, Nafiye
   Balci, Osman
   Adam, Magdi
   Yaman, Selen Taflan
TI Evaluation of Oxidative Stress in Women with Polycystic Ovarian Syndrome
   as Represented by Serum Ischemia Modified Albumin and Its Correlation
   with Testosterone and Insulin Resistance
SO INTERNAL MEDICINE
LA English
DT Article
DE polycystic ovary syndrome; unexplained infertility; ischemia-modified
   albumin; insulin; testosterone
ID MYOCARDIAL-ISCHEMIA; METABOLIC SYNDROME; MARKER; BIOMARKERS;
   INFLAMMATION; ASSOCIATION; INFARCTION; BINDING; DISEASE; LIPIDS
AB Objective Ischemia-mediated oxidative stress and inflammation have been reported to be important contributors to the pathogenesis of polycystic ovary syndrome (PCOS). Ischemia-modified albumin (IMA) is a novel marker generated under ischemic and oxidative conditions and may reflect disease activity in distinct disease states. Therefore, we investigated whether the serum IMA levels are affected in infertile PCOS patients.
   Methods Forty-six patients with infertile PCOS, 30 patients with unexplained infertility, and 31 age-and body mass index (BMI)-matched controls were included in this cross-sectional study. Biochemical parameters, serum IMA levels, and their correlations with serum testosterone and insulin resistance were determined for each subject.
   Results In patients with infertile PCOS, the serum IMA levels were significantly elevated (p=0.003) compared with unexplained infertility patients and controls. A correlation analysis suggested that the IMA levels only correlated with the serum free testosterone levels in PCOS patients (r=0.43, p=0.028).
   Conclusion Elevations in the serum IMA levels in infertile PCOS patients may suggest a possible additional role of oxidative stress mechanisms in disease pathophysiology. Moreover, correlation between serum IMA and testosterone levels may influence the quality of oocytes via alterations in the balance of critical follicular fluid factors in the follicular microenvironment.
C1 [Beyazit, Fatma] Canakkale Onsekiz Mart Univ, Dept Obstet & Gynecol, Canakkale, Turkey.
   [Yilmaz, Nafiye; Adam, Magdi; Yaman, Selen Taflan] Dr Zekai Tahir Burak Womens Hlth Educ & Res Hosp, Dept Reprod Endocrinol & IVF, Ankara, Turkey.
   [Balci, Osman] Selcuk Univ, Meram Med Fac, Dept Obstet & Gynecol, Konya, Turkey.
C3 Canakkale Onsekiz Mart University; Dr. Zekai Tahir Burak Women's Health
   Research & Education Hospital; Anatolia IVF Center; Selcuk University
RP Beyazit, F (corresponding author), Canakkale Onsekiz Mart Univ, Dept Obstet & Gynecol, Canakkale, Turkey.
EM fatmabeyazit@yahoo.com
RI yaman, selen/HSD-6994-2023
OI Yilmaz, Nafiye/0000-0002-4041-297X
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NR 31
TC 17
Z9 18
U1 0
U2 7
PU JAPAN SOC INTERNAL MEDICINE
PI TOKYO
PA 34-3 3-CHOME HONGO BUNKYO-KU, TOKYO, 113, JAPAN
SN 0918-2918
EI 1349-7235
J9 INTERNAL MED
JI Intern. Med.
PY 2016
VL 55
IS 17
BP 2359
EP 2364
DI 10.2169/internalmedicine.55.6265
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA DV6CB
UT WOS:000383017300005
PM 27580534
OA gold
DA 2025-06-11
ER

PT J
AU Albert, SL
   Massar, RE
   Kwok, L
   Correa, L
   Polito-Moller, K
   Joshi, S
   Shah, S
   McMacken, M
AF Albert, Stephanie L.
   Massar, Rachel E.
   Kwok, Lorraine
   Correa, Lilian
   Polito-Moller, Krisann
   Joshi, Shivam
   Shah, Sapana
   McMacken, Michelle
TI Pilot Plant-Based Lifestyle Medicine Program in an Urban Public
   Healthcare System: Evaluating Demand and Implementation
SO AMERICAN JOURNAL OF LIFESTYLE MEDICINE
LA English
DT Article; Early Access
DE Plant-based diet; lifestyle medicine; chronic disease; behavior change;
   lifestyle modification; cardiovascular risk; implementation evaluation
ID CORONARY-HEART-DISEASE; MEDITERRANEAN DIET; RISK; PREVENTION; REDUCTION;
   ADHERENCE; MORTALITY
AB Lifestyle interventions that optimize nutrition, physical activity, sleep health, social connections, and stress management, and address substance use, can reduce cardiometabolic risk. Despite substantial evidence that healthful plant-based diets are beneficial for long-term cardiometabolic health and longevity, uncertainty lies in how to implement plant-based lifestyle programs in traditional clinical settings, especially in safety-net contexts with finite resources. In this mixed-methods implementation evaluation of the Plant-Based Lifestyle Medicine Program piloted in a large public healthcare system, we surveyed participants and conducted qualitative interviews and focus groups with stakeholders to assess program demand in the eligible population and feasibility of implementation within the safety-net setting. Program demand was high and exceeded capacity. Participants' main motivations for joining the program included gaining more control over life, reducing medication, and losing weight. The program team, approach, and resources were successful facilitators. However, the program faced administrative and payor-related challenges within the safety-net setting, and participants reported barriers to access. Stakeholders found the program to be valuable, despite challenges in program delivery and access. Findings provide guidance for replication. Future research should focus on randomized controlled trials to assess clinical outcomes as a result of program participation.
C1 [Albert, Stephanie L.; Massar, Rachel E.; Kwok, Lorraine] NYU Grossman Sch Med, Dept Populat Hlth, 180 Madison Ave,2nd Floor, New York, NY 10016 USA.
   [Correa, Lilian; Polito-Moller, Krisann; Joshi, Shivam; Shah, Sapana; McMacken, Michelle] NYC Hlth Hosp Bellevue, Dept Med, New York, NY USA.
   [Joshi, Shivam; Shah, Sapana; McMacken, Michelle] NYU Grossman Sch Med, Dept Med, New York, NY USA.
   [McMacken, Michelle] NYC Hlth Hosp, Off Ambulatory Care & Populat Hlth, New York, NY USA.
C3 Bellevue Hospital Center
RP Albert, SL (corresponding author), NYU Grossman Sch Med, Dept Populat Hlth, 180 Madison Ave,2nd Floor, New York, NY 10016 USA.
EM stephanie.albert@nyulangone.org
OI Massar, Rachel/0000-0001-5754-3231
FU NYC Health + Hospitals
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: This work
   was supported by NYC Health + Hospitals.
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NR 33
TC 6
Z9 6
U1 0
U2 4
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1559-8276
EI 1559-8284
J9 AM J LIFESTYLE MED
JI Am. J. Lifestyle Med.
PD 2022 JUL 12
PY 2022
DI 10.1177/15598276221113507
EA JUL 2022
PG 17
WC Public, Environmental & Occupational Health
WE Emerging Sources Citation Index (ESCI)
SC Public, Environmental & Occupational Health
GA 2U9XP
UT WOS:000823507200001
PM 38737881
OA Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Beranek, M
   Borsky, P
   Fiala, Z
   Andrys, C
   Hamakova, K
   Chmelarova, M
   Kovarikova, H
   Karas, A
   Kremlacek, J
   Palicka, V
   Borska, L
AF Beranek, Martin
   Borsky, Pavel
   Fiala, Zdenek
   Andrys, Ctirad
   Hamakova, Kvetoslava
   Chmelarova, Marcela
   Kovarikova, Helena
   Karas, Adam
   Kremlacek, Jan
   Palicka, Vladimir
   Borska, Lenka
TI Telomere length, oxidative and epigenetic changes in blood DNA of
   patients with exacerbated psoriasis vulgaris
SO ANAIS BRASILEIROS DE DERMATOLOGIA
LA English
DT Article
DE Blood; DNA; Epigenomics; Methylation; Oxidative stress; Psoriasis;
   Telomere
ID T-CELLS; METHYLATION; DISEASE; NEUTROPHILS; CYTOKINES; EXPOSURE;
   PROMOTER; STRESS; MARKER; GENE
AB Background: The pathogenesis of psoriasis vulgaris involves changes in DNA molecules, genomic instability, telomere attrition, and epigenetic alterations among them. These changes are also considered important mechanisms of aging in cells and tissues. Objective: This study dealt with oxidation damage, telomere length and methylation status in DNA originating from peripheral blood of 41 psoriatic patients and 30 healthy controls. Methods: Oxidative damage of serum DNA/RNA was determined immunochemically. Real-time PCR was used for the analysis of the telomere length. ELISA technique determined levels of 5-methylcytosine in blood cells' DNA. Results: Oxidative damage of serum DNA/RNA was higher in patients than in controls (median, 3758 vs. 2286 pg/mL, p < 0.001). A higher length of telomeres per chromosome was found in patients whole-cell DNA than in controls (3.57 vs. 3.04 kilobases, p = 0.011). A negative corre-lation of the length of telomeres with an age of the control subjects was revealed (Spearman's rho =-0.420, p = 0.028). Insignificantly different levels of 5-methylcytosine in patients and con-trols were observed (33.20 vs. 23.35%, p = 0.234). No influences of sex, smoking, BMI, PASI score, and metabolic syndrome on the methylation status were found. Study limitations: i) A relatively small number of the participants, particularly for reliable subgroup analyses, ii) the Caucasian origin of the participants possibly influencing the results of the parameters determined, and iii) Telomerase activity was not directly measured in serum or blood cells. Conclusion: The study demonstrated increased levels of oxidized DNA/RNA molecules in the serum of patients with exacerbated psoriasis vulgaris. The results were minimally influenced by sex, the presence of metabolic syndrome, or cigarette smoking. In the psoriatic blood cells' DNA, the authors observed longer telomeres compared to healthy controls, particularly in females. Insignificantly higher global DNA methylation in psoriasis cases compared to the controls indicated marginal clinical importance of this epigenetic test performed in the blood cells' DNA. (c) 2022 Sociedade Brasileira de Dermatologia. Published by Elsevier Espana, S.L.U. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
C1 [Beranek, Martin; Chmelarova, Marcela; Kovarikova, Helena; Palicka, Vladimir] Charles Univ Prague, Univ Hosp Hradec Kralove, Inst Clin Biochem & Diagnost, Fac Med, Hradec Kralove, Czech Republic.
   [Beranek, Martin] Charles Univ Prague, Fac Pharm, Dept Biochem Sci, Hradec Kralove, Czech Republic.
   [Borsky, Pavel; Fiala, Zdenek; Karas, Adam; Borska, Lenka] Charles Univ Prague, Inst Prevent Med, Fac Med, Hradec Kralove, Czech Republic.
   [Andrys, Ctirad] Charles Univ Prague, Inst Clin Immunol & Allergol, Fac Med, Hradec Kralove, Czech Republic.
   [Hamakova, Kvetoslava] Univ Hosp Hradec Kralove, Clin Dermatol & Venereol, Hradec Kralove, Czech Republic.
   [Kremlacek, Jan] Charles Univ Prague, Fac Med, Dept Med Biophys, Hradec Kralove, Czech Republic.
C3 University Hospital Hradec Kralove; Charles University Prague; Charles
   University Prague; University Hospital Hradec Kralove; Charles
   University Prague; University Hospital Hradec Kralove; Charles
   University Prague; University Hospital Hradec Kralove; Charles
   University Prague; University Hospital Hradec Kralove
RP Beranek, M (corresponding author), Charles Univ Prague, Univ Hosp Hradec Kralove, Inst Clin Biochem & Diagnost, Fac Med, Hradec Kralove, Czech Republic.
EM beranek@lfhk.cuni.cz
RI Kremlacek, Jan/A-4313-2008; Palicka, Vladimir/N-1802-2017; Borsky,
   Pavel/S-6307-2016; Beranek, Martin/A-9644-2017; Parova,
   Helena/S-4857-2016; Fiala, Zdenek/E-5962-2017
OI Kremlacek, Jan/0000-0001-8641-4287; Palicka,
   Vladimir/0000-0001-7236-1647; Borsky, Pavel/0000-0001-5253-2808; Andrys,
   Ctirad/0000-0001-6489-8786; Beranek, Martin/0000-0002-7422-722X; Parova,
   Helena/0000-0001-5040-4140; Fiala, Zdenek/0000-0001-9978-5757
FU Charles University, Faculty of Medicine in Hradec Kralove, Czech
   Republic [SVV-260543/2020]
FX This research was funded by the projects COOPERATIO UK and
   SVV-260543/2020 of Charles University, Faculty of Medicine in Hradec
   Kralove, Czech Republic.
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NR 39
TC 3
Z9 3
U1 0
U2 2
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0365-0596
EI 1806-4841
J9 AN BRAS DERMATOL
JI An. Brasil. Dermatol.
PD JAN-FEB
PY 2023
VL 98
IS 1
BP 68
EP 74
DI 10.1016/j.abd.2022.01.008
EA JAN 2023
PG 7
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA C6QI6
UT WOS:000963135900001
PM 36319514
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Moskaleva, NE
   Shestakova, KM
   Kukharenko, AV
   Markin, PA
   Kozhevnikova, MV
   Korobkova, EO
   Brito, A
   Baskhanova, SN
   Mesonzhnik, NV
   Belenkov, YN
   Pyatigorskaya, NV
   Tobolkina, E
   Rudaz, S
   Appolonova, SA
AF Moskaleva, Natalia E.
   Shestakova, Ksenia M.
   Kukharenko, Alexey V.
   Markin, Pavel A.
   Kozhevnikova, Maria V.
   Korobkova, Ekaterina O.
   Brito, Alex
   Baskhanova, Sabina N.
   Mesonzhnik, Natalia V.
   Belenkov, Yuri N.
   Pyatigorskaya, Natalia V.
   Tobolkina, Elena
   Rudaz, Serge
   Appolonova, Svetlana A.
TI Target Metabolome Profiling-Based Machine Learning as a Diagnostic
   Approach for Cardiovascular Diseases in Adults
SO METABOLITES
LA English
DT Article
DE metabolites; amino acids; acylcarnitines; tryptophan catabolism;
   methylarginines; cardiovascular disorders; hypertension; coronary heart
   disease; translational medicine; machine learning
ID CORONARY-ARTERY-DISEASE; CHAIN AMINO-ACIDS; CLINICAL ENDOCRINOLOGISTS;
   AMERICAN ASSOCIATION; PLASMA; RISK; HEART; RECOMMENDATIONS;
   QUANTIFICATION; ACYLCARNITINES
AB Metabolomics is a promising technology for the application of translational medicine to cardiovascular risk. Here, we applied a liquid chromatography/tandem mass spectrometry approach to explore the associations between plasma concentrations of amino acids, methylarginines, acylcarnitines, and tryptophan catabolism metabolites and cardiometabolic risk factors in patients diagnosed with arterial hypertension (HTA) (n = 61), coronary artery disease (CAD) (n = 48), and non-cardiovascular disease (CVD) individuals (n = 27). In total, almost all significantly different acylcarnitines, amino acids, methylarginines, and intermediates of the kynurenic and indolic tryptophan conversion pathways presented increased (p < 0.05) in concentration levels during the progression of CVD, indicating an association of inflammation, mitochondrial imbalance, and oxidative stress with early stages of CVD. Additionally, the random forest algorithm was found to have the highest prediction power in multiclass and binary classification patients with CAD, HTA, and non-CVD individuals and globally between CVD and non-CVD individuals (accuracy equal to 0.80 and 0.91, respectively). Thus, the present study provided a complex approach for the risk stratification of patients with CAD, patients with HTA, and non-CVD individuals using targeted metabolomics profiling.
C1 [Moskaleva, Natalia E.; Shestakova, Ksenia M.; Markin, Pavel A.; Baskhanova, Sabina N.; Mesonzhnik, Natalia V.] IM Sechenov First Moscow State Med Univ, World Class Res Ctr Digital Biodesign & Personaliz, Moscow 119435, Russia.
   [Kukharenko, Alexey V.; Brito, Alex; Appolonova, Svetlana A.] IM Sechenov First Moscow Med Univ, Inst Translat Med & Biotechnol, Lab Pharmacokinet & Metabol Anal, Moscow 119435, Russia.
   [Kozhevnikova, Maria V.; Korobkova, Ekaterina O.; Belenkov, Yuri N.] IM Sechenov First Moscow Med Univ, Hosp Therapy Dept 1, NV Sklifosovsky Inst Clin Med, Moscow 119992, Russia.
   [Pyatigorskaya, Natalia V.; Appolonova, Svetlana A.] IM Sechenov First Moscow State Med Univ, Inst Vocat Educ, Dept Ind Pharm, Moscow 119435, Russia.
   [Tobolkina, Elena; Rudaz, Serge] Univ Geneva, Inst Pharmaceut Sci Western Switzerland, CH-1206 Geneva, Switzerland.
C3 Sechenov First Moscow State Medical University; Sechenov First Moscow
   State Medical University; Sechenov First Moscow State Medical
   University; Sechenov First Moscow State Medical University; University
   of Geneva
RP Tobolkina, E (corresponding author), Univ Geneva, Inst Pharmaceut Sci Western Switzerland, CH-1206 Geneva, Switzerland.
EM elena.tobolkina@unige.ch
RI Shestakova, Kseniia/AAB-9673-2020; Brito, Alex/I-2858-2013;
   Kozhevnikova, Maria/B-4112-2018; Baskhanova, Sabina/AFE-8324-2022;
   Korobkova, Ekaterina/ABD-2193-2021; Markin, Pavel/AAI-2505-2020; Rudaz,
   Serge/AAB-2861-2021; Mesonzhnik, Natalia/KIA-2963-2024; Appolonova,
   Svetlana/J-7802-2016
OI Korobkova, Ekaterina/0000-0003-2873-704X; Markin,
   Pavel/0000-0002-2240-2903; Baskhanova, Sabina/0000-0001-8716-1672;
   Brito, Alex/0000-0002-6212-8814; Mesonzhnik,
   Natalia/0000-0001-8860-5853; Appolonova, Svetlana/0000-0002-9032-1558;
   Rudaz, Serge/0000-0002-4180-5417; Moskaleva,
   Natalia/0000-0002-7309-8913; Kozhevnikova, Maria/0000-0003-4778-7755
FU Ministry of Science and Higher Education of the Russian Federation
   [075-15-2022-304]
FX The work was financed by the Ministry of Science and Higher Education of
   the Russian Federation within the framework of state support for the
   creation and development of a World-Class Research Centers "Digital
   Biodesign and Personalized Healthcare" No. 075-15-2022-304.
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NR 51
TC 11
Z9 12
U1 1
U2 10
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2218-1989
J9 METABOLITES
JI Metabolites
PD DEC
PY 2022
VL 12
IS 12
AR 1185
DI 10.3390/metabo12121185
PG 22
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 7J0GY
UT WOS:000904267000001
PM 36557222
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Lee, SH
   Paz, G
   Mastronardi, C
   Licinio, J
   Wong, ML
AF Lee, S. H.
   Paz-Filho, G.
   Mastronardi, C.
   Licinio, J.
   Wong, M-L
TI Is increased antidepressant exposure a contributory factor to the
   obesity pandemic?
SO TRANSLATIONAL PSYCHIATRY
LA English
DT Review
ID MAJOR DEPRESSIVE DISORDER; SEROTONIN REUPTAKE INHIBITORS; BODY-MASS
   INDEX; HIGH-FAT DIET; 3RD NATIONAL-HEALTH; GROWTH-FACTOR-I; METABOLIC
   SYNDROME; WEIGHT-GAIN; LEPTIN LEVELS; NEUROPEPTIDE-Y
AB Major depressive disorder (MDD) and obesity are both common heterogeneous disorders with complex aetiology, with a major impact on public health. Antidepressant prescribing has risen nearly 400% since 1988, according to data from the Centers for Disease Control and Prevention (CDC). In parallel, adult obesity rates have doubled since 1980, from 15 to 30 percent, while childhood obesity rates have more than tripled. Rising obesity rates have significant health consequences, contributing to increased rates of more than thirty serious diseases. Despite the concomitant rise of antidepressant use and of the obesity rates in Western societies, the association between the two, as well as the mechanisms underlying antidepressant-induced weight gain, remain under explored. In this review, we highlight the complex relationship between antidepressant use, MDD and weight gain. Clinical findings have suggested that obesity may increase the risk of developing MDD, and vice versa. Hypothalamic-pituitary-adrenal (HPA) axis activation occurs in the state of stress; concurrently, the HPA axis is also dysregulated in obesity and metabolic syndrome, making it the most well-understood shared common pathophysiological pathway with MDD. Numerous studies have investigated the effects of different classes of antidepressants on body weight. Previous clinical studies suggest that the tricyclics amitriptyline, nortriptyline and imipramine, and the serotonin norepinephrine reuptake inhibitor mirtazapine are associated with weight gain. Despite the fact that selective serotonin reuptake inhibitor (SSRI) use has been associated with weight loss during acute treatment, a number of studies have shown that SSRIs may be associated with long-term risk of weight gain; however, because of high variability and multiple confounds in clinical studies, the long-term effect of SSRI treatment and SSRI exposure on body weight remains unclear. A recently developed animal paradigm shows that the combination of stress and antidepressants followed by long-term high-fat diet results, long after discontinuation of antidepressant treatment, in markedly increased weight, in excess of what is caused by high-fat diet alone. On the basis of existing epidemiological, clinical and preclinical data, we have generated the testable hypothesis that escalating use of antidepressants, resulting in high rates of antidepressant exposure, might be a contributory factor to the obesity epidemic.
C1 [Lee, S. H.; Paz-Filho, G.; Mastronardi, C.] Australian Natl Univ, John Curtin Sch Med Res, Dept Genome Sci, Canberra, ACT 2601, Australia.
   [Licinio, J.; Wong, M-L] South Australian Hlth & Med Res Inst, Pharmacogen Res Program, Mind & Brain Theme, POB 11060, Adelaide, SA 5001, Australia.
   [Licinio, J.; Wong, M-L] Flinders Univ S Australia, Sch Med, Dept Psychiat, POB 11060, Adelaide, SA 5001, Australia.
C3 Australian National University; John Curtin School of Medical Research;
   South Australian Health & Medical Research Institute (SAHMRI); Flinders
   University South Australia
RP Wong, ML (corresponding author), South Australian Hlth & Med Res Inst, Pharmacogen Res Program, Mind & Brain Theme, POB 11060, Adelaide, SA 5001, Australia.; Wong, ML (corresponding author), Flinders Univ S Australia, Sch Med, Dept Psychiat, POB 11060, Adelaide, SA 5001, Australia.
EM mali.wong@sahmri.com
RI Wong, Ma-Li/ABD-5525-2020; Paz-Filho, Gilberto/C-6499-2008; Mastronardi,
   Claudio/J-8913-2017; Wong, Ma-Li/D-7903-2011; Licinio, Julio/L-4244-2013
OI Mastronardi, Claudio/0000-0002-0777-9075; Wong,
   Ma-Li/0000-0003-1512-3073; Licinio, Julio/0000-0001-6905-5884
FU National Health and Medical Research Council, Australia [APP1070935]
FX This study was supported by the grant APP1070935 from the National
   Health and Medical Research Council, Australia.
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NR 131
TC 97
Z9 107
U1 3
U2 32
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 2158-3188
J9 TRANSL PSYCHIAT
JI Transl. Psychiatr.
PD MAR 15
PY 2016
VL 6
AR e759
DI 10.1038/tp.2016.25
PG 12
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychiatry
GA DJ0OX
UT WOS:000373904900005
PM 26978741
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Christodoulou, A
   Nikolaou, PE
   Symeonidi, L
   Katogiannis, K
   Pechlivani, L
   Nikou, T
   Varela, A
   Chania, C
   Zerikiotis, S
   Efentakis, P
   Vlachodimitropoulos, D
   Katsoulas, N
   Agapaki, A
   Dimitriou, C
   Tsoumani, M
   Kostomitsopoulos, N
   Davos, CH
   Skaltsounis, AL
   Tselepis, A
   Halabalaki, M
   Tseti, I
   Iliodromitis, EK
   Ikonomidis, I
   Andreadou, I
AF Christodoulou, Andriana
   Nikolaou, Panagiota-Efstathia
   Symeonidi, Lydia
   Katogiannis, Konstantinos
   Pechlivani, Louisa
   Nikou, Theodora
   Varela, Aimilia
   Chania, Christina
   Zerikiotis, Stelios
   Efentakis, Panagiotis
   Vlachodimitropoulos, Dimitris
   Katsoulas, Nikolaos
   Agapaki, Anna
   Dimitriou, Costantinos
   Tsoumani, Maria
   Kostomitsopoulos, Nikolaos
   Davos, Constantinos H.
   Skaltsounis, Alexios Leandros
   Tselepis, Alexandros
   Halabalaki, Maria
   Tseti, Ioulia
   Iliodromitis, Efstathios K.
   Ikonomidis, Ignatios
   Andreadou, Ioanna
TI Cardioprotective potential of oleuropein, hydroxytyrosol, oleocanthal
   and their combination: Unravelling complementary effects on acute
   myocardial infarction and metabolic syndrome
SO REDOX BIOLOGY
LA English
DT Article
DE Cardiometabolic syndrome; Ischemia-reperfusion injury; Oleuropein;
   Hydroxytyrosol; Oleocanthal; Oleanolic acid
ID ISCHEMIA-REPERFUSION INJURY; VIRGIN OLIVE OIL; HIGH-FAT-DIET;
   ISCHEMIA/REPERFUSION INJURY; OLEANOLIC ACID; MEDITERRANEAN DIET;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; ADIPOSE-TISSUE; LIPID PROFILE
AB Clinical studies have previously established the role of olive products in cardiovascular disease (CVD) prevention, whilst the identification of the responsible constituents for the beneficial effects is still pending. We sought to assess and compare the cardioprotective potential of oleuropein (OL), hydroxytyrosol (HT), oleocanthal (OC) and oleanolic Acid (OA), regarding Ischemia/Reperfusion Injury (IRI) and CVD risk factors alleviation. The scope of the study was to design a potent and safe combinatorial therapy for high-cardiovascular-risk patients on a bench-to-bedside approach. We evaluated the IRI-limiting potential of 6-weeks treatment with OL, HT, OC or OA at nutritional doses, in healthy and metabolic syndrome (MS)-burdened mice. Three combinatorial regimens were designed and the mixture with preponderant benefits (OL-HT-OC, Combo 2), including infarct sparing and antiglycemic potency, compared to the isolated compounds, was further investigated for its anti-atherosclerotic effects. In vivo experiments revealed that the combination regimen of Combo 2 presented the most favorable effects in limiting infarct size and hyperglycemia, which was selected to be further investigated in the clinical setting in Chronic Coronary Artery Syndrome (CCAS) patients. Cardiac function, inflammation markers and oxidative stress were assessed at baseline and after 4 weeks of treatment with the OL-HT-OC supplement in the clinical study. We found that OL, OC and OA significantly reduced infarct size in vivo compared to Controls. OL exhibited antihyperglycemic properties and OA attenuated hypercholesterolemia. OL-HT-OA, OL-HT-OC and OLHT-OC-OA combination regimens were cardioprotective, whereas only OL-HT-OC mitigated hyperglycemia. Combo 2 cardioprotection was attributed to apoptosis suppression, enhanced antioxidant effects and upregulation of antioxidant enzymes. Additionally, it reduced atherosclerotic plaque extent in vivo. . OL-HT-OC supplement ameliorated cardiac, vascular and endothelial function in the small-scale clinical study. Conclusively, OL-HT-OC combination therapy exerts potent cardioprotective, antihyperglycemic and anti-atherosclerotic properties in vivo, , with remarkable and clinically translatable cardiovascular benefits in high-risk patients.
C1 [Christodoulou, Andriana; Nikolaou, Panagiota-Efstathia; Symeonidi, Lydia; Chania, Christina; Zerikiotis, Stelios; Efentakis, Panagiotis; Tsoumani, Maria; Andreadou, Ioanna] Natl & Kapodistrian Univ Athens, Fac Pharm, Lab Pharmacol, Athens, Greece.
   [Katogiannis, Konstantinos; Ikonomidis, Ignatios] Natl & Kapodistrian Univ Athens, Attikon Univ Hosp, Med Sch, Lab Echocardiog & Prevent Cardiol,Cardiol Dept 2, Athens, Greece.
   [Pechlivani, Louisa; Tselepis, Alexandros] Univ Ioannina, Atherothrombosis Res Ctr, Dept Chem, Lab Biochem, Ioannina, Greece.
   [Nikou, Theodora; Skaltsounis, Alexios Leandros; Halabalaki, Maria] Natl & Kapodistrian Univ Athens, Dept Pharm, Div Pharmacognosy & Nat Prod Chem, Athens, Greece.
   [Varela, Aimilia; Davos, Constantinos H.] Acad Athens BRFAA, Biomed Res Fdn, Cardiovasc Res Lab, Athens, Greece.
   [Vlachodimitropoulos, Dimitris; Katsoulas, Nikolaos] Natl & Kapodistrian Univ Athens, Med Sch, Lab Forens Med & Toxicol, Athens, Greece.
   [Agapaki, Anna] Acad Athens BRFAA, Biomed Res Fdn, Histochem Unit, Athens, Greece.
   [Dimitriou, Costantinos; Kostomitsopoulos, Nikolaos] Acad Athens BRFAA, Biomed Res Fdn, Ctr Clin Expt Surg & Translat Res, Athens, Greece.
   [Tseti, Ioulia] Unipharma SA, Athens, Greece.
   [Iliodromitis, Efstathios K.] Natl & Kapodistrian Univ Athens, Med Sch, Athens, Greece.
C3 National & Kapodistrian University of Athens; University Hospital
   Attikon; National & Kapodistrian University of Athens; University of
   Ioannina; National & Kapodistrian University of Athens; Academy of
   Athens; National & Kapodistrian University of Athens; Academy of Athens;
   Academy of Athens; National & Kapodistrian University of Athens
RP Andreadou, I (corresponding author), Fac Pharm, Lab Pharmacol, Athens 15771, Greece.
EM jandread@pharm.uoa.gr
RI Katogiannis, Konstantinos/AAX-1156-2020; NIKOLAOU,
   PANAGIOTA/AAK-2744-2021; Halabalaki, Maria/AAD-2127-2020; skaltsounis,
   alexios/AAE-9617-2019
FU Operational Program "Competitiveness, Entrepreneurship and Innovation"
   of the General Secretariat for Research and Innovation; Hellenic
   Rebublic Ministry of Development, Greece [5048539]; Hellenic
   Atherosclerosis Society, Greece
FX This work was supported by the Operational Program "Competitiveness,
   Entrepreneurship and Innovation" of the General Secretariat for Research
   and Innovation, Hellenic Rebublic Ministry of Development, Greece under
   the call "RESEARCH - CREATE-INNOVATE" (project code: 5048539) and by a
   research grant from the Hellenic Atherosclerosis Society, Greece.
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NR 98
TC 6
Z9 6
U1 3
U2 8
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2213-2317
J9 REDOX BIOL
JI Redox Biol.
PD OCT
PY 2024
VL 76
AR 103311
DI 10.1016/j.redox.2024.103311
EA AUG 2024
PG 19
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA D7D7P
UT WOS:001297756900001
PM 39153251
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Yousif, HA
   Hami, MA
AF Yousif, Hiba A.
   Hami, Mohammed A.
TI Effect of waterpipe smoking and its cessation on metabolic biomarkers
   and a novel biomarker omentin-1
SO BIOMARKERS
LA English
DT Article
DE Waterpipe smoking; WPS cessation; oxidative stress; metabolic
   biomarkers; omentin-1
ID CARDIOMETABOLIC RISK-FACTORS; INSULIN-RESISTANCE; CIGARETTE; SMOKERS
AB Background and ObjectiveWaterpipe smoking (WPS) has increased globally and may lead to various metabolic disorders. However, its long-term effects and cessation impact on metabolic biomarkers and omentin-1 remain unclear. This study aims to evaluate the impact of WPS and its cessation on metabolic biomarkers and omentin-1 levels and explore their correlations.Materials and Methods90 individuals were categorized into three groups (non-smokers, waterpipe smokers and cessation of waterpipe smokers). FBS and lipid profiles including TC, TG and HDL were measured using the Cobas 6000 c501 system, while FI was analyzed with the Cobas 6000 c601 system. Omentin-1 concentrations were determined using the enzyme-linked immunosorbent assay (ELISA) with a human omentin ELISA kit.ResultsFI, HOMA-IR and lipid profiles were significantly elevated in WPS and cessation groups. Omentin-1 and DBP levels significantly decreased in both groups compared to non-smokers. Increased WPS duration leads to reduced BMI, WC and DBP, while cessation duration decreases FBS and SBP. A negative association was identified among omentin-1 with FBS and O2.ConclusionWPS and its cessation adversely affect metabolic health, reducing omentin-1 levels and increasing the risk of metabolic disorders. Over time, cessation improves specific biochemical markers, highlighting the need for public health awareness.
C1 [Yousif, Hiba A.; Hami, Mohammed A.] Univ Zakho, Coll Sci, Chem Dept, Zakho, Kurdistan, Iraq.
C3 University of Zakho
RP Yousif, HA (corresponding author), Univ Zakho, Coll Sci, Chem Dept, Zakho, Kurdistan, Iraq.
EM hibaauni1999@gmail.com
RI Hami, Mohammed/GRO-0743-2022
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NR 47
TC 1
Z9 1
U1 0
U2 0
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1354-750X
EI 1366-5804
J9 BIOMARKERS
JI Biomarkers
PD APR 3
PY 2025
VL 30
IS 3
BP 219
EP 225
DI 10.1080/1354750X.2025.2479664
EA MAR 2025
PG 7
WC Biotechnology & Applied Microbiology; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Toxicology
GA 3DE0O
UT WOS:001449094300001
PM 40084921
DA 2025-06-11
ER

PT J
AU Castrejón-Téllez, V
   Villegas-Romero, M
   Rubio-Ruiz, ME
   Pérez-Torres, I
   Carreón-Torres, E
   Díaz-Díaz, E
   Guarner-Lans, V
AF Castrejon-Tellez, Vicente
   Villegas-Romero, Mariana
   Esther Rubio-Ruiz, Maria
   Perez-Torres, Israel
   Carreon-Torres, Elizabeth
   Diaz-Diaz, Eulises
   Guarner-Lans, Veronica
TI Effect of a Resveratrol/Quercetin Mixture on the Reversion of
   Hypertension Induced by a Short-Term Exposure to High Sucrose Levels
   Near Weaning and a Long-Term Exposure That Leads to Metabolic Syndrome
   in Rats
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE hypertension; resveratrol; quercetin; eNOS; oxidative stress; sucrose;
   critical window near weaning; sirtuins
ID NITRIC-OXIDE; INSULIN-RESISTANCE; OXIDATIVE STRESS; QUERCETIN; SIRTUINS;
   SIRT1; BIOAVAILABILITY; RESTRICTION; ACTIVATION; IMPROVES
AB Hypertension is an important global public health problem. Excess sucrose during a short period near weaning (short sucrose period, SSP; sucrose during rat postnatal days 12 to 28) increases the risk of developing hypertension during adulthood and sucrose ingestion for 6 months after weaning also results in metabolic syndrome (MS) accompanied by hypertension. The aim of this study was to test if the mechanisms that lead to hypertension induced by SSP and MS are similarly modified by a resveratrol/quercetin mixture (RSV/QSC) that targets epigenetic cues. We studied the reversion of hypertension by an RSV/QSC mixture administered for 1 month (from month 6 to month 7 of age) in these two models, since it is effective against some signs of MS. RSV/QSC might determine Sirtuin 1 (SIRT1) and Sirtuin 3 (SIRT3) expression that modulates the expression of endothelial nitric oxide synthase (eNOS), which synthesizes nitric oxide (NO), and of superoxide dismutases (SOD1 and 2), which are antioxidant enzymes that have an impact on the NO levels. Short- (SSP) and long-term (MS) exposure to sucrose induced hypertension and RSV/QSC reversed it. It increased the insulin sensitivity, which may determine the eNOS expression. eNOS expression was decreased in aortas from SSP and MS rats and RSV/QSC only elevated its levels in aortas from MS rats. SIRT1 was also only increased in the MS aortas. Hypertension was accompanied by a decrease in total non-enzymatic antioxidant defenses in SSP and MS aortas, which improved with the RSV/QSC treatment. SOD1 expression was not modified by the sucrose treatments, but SOD2 expression was decreased in SSP and MS aortas. The RSV/QSC treatment increased SOD1 expression in MS aortas. SIRT3 was not modified by the sucrose or RSV/QSC treatments. In conclusion, SSP and MS lead to hypertension, but MS leads to more possible epigenetically- regulated mechanisms related to high blood pressure that could be targeted by the RSV/QSC mixture. Therefore, treatment has better effects on hypertension produced by MS.
C1 [Castrejon-Tellez, Vicente; Villegas-Romero, Mariana; Esther Rubio-Ruiz, Maria; Guarner-Lans, Veronica] Inst Nacl Cardiol Ignacio Chavez, Dept Physiol, Juan Badiano 1,Secc 16, Mexico City 14080, DF, Mexico.
   [Perez-Torres, Israel] Inst Nacl Cardiol Ignacio Chavez, Dept Cardiovasc Biomed, Juan Badiano 1,Secc 16, Mexico City 14080, DF, Mexico.
   [Carreon-Torres, Elizabeth] Inst Nacl Cardiol Ignacio Chavez, Dept Mol Biol, Juan Badiano 1,Secc 16, Mexico City 14080, DF, Mexico.
   [Diaz-Diaz, Eulises] Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Reprod Biol, Vasco de Quiroga 15,Secc 16, Mexico City 14000, DF, Mexico.
C3 National Institute of Cardiology - Mexico; National Institute of
   Cardiology - Mexico; National Institute of Cardiology - Mexico;
   Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran -
   Mexico
RP Guarner-Lans, V (corresponding author), Inst Nacl Cardiol Ignacio Chavez, Dept Physiol, Juan Badiano 1,Secc 16, Mexico City 14080, DF, Mexico.
EM vicente.castrejon@cardiologia.org.mx; mvromero21@gmail.com;
   esther.rubio@cardiologia.org.mx; israel.perez@cardiologia.org.mx;
   juana.carreon@cardiologia.org.mx; eulises.diazd@incmnsz.mx;
   veronica.guarner@cardiologia.org.mx
RI Guarner-Lans, Verónica/AFW-3723-2022; Pérez Torres, Israel/AAE-2579-2022
OI Perez-Torres, Israel/0000-0001-6510-2954; Castrejon Tellez,
   Vicente/0000-0002-8518-6961; Guarner-Lans, Veronica/0000-0002-2655-7590
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NR 47
TC 14
Z9 15
U1 0
U2 6
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD MAR
PY 2020
VL 21
IS 6
AR 2231
DI 10.3390/ijms21062231
PG 17
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA LJ0UU
UT WOS:000529890200327
PM 32210194
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Baye, E
   Kiriakova, V
   Uribarri, J
   Moran, LJ
   de Courten, B
AF Baye, Estifanos
   Kiriakova, Velislava
   Uribarri, Jaime
   Moran, Lisa J.
   de Courten, Barbora
TI Consumption of diets with low advanced glycation end products improves
   cardiometabolic parameters: meta-analysis of randomised controlled
   trials
SO SCIENTIFIC REPORTS
LA English
DT Article
ID MAILLARD REACTION-PRODUCTS; OXIDATIVE STRESS; ENDOTHELIAL FUNCTION;
   INSULIN-RESISTANCE; SERUM-LEVELS; RISK-FACTOR; INFLAMMATION;
   RESTRICTION; INDIVIDUALS; ADIPONECTIN
AB Studies examining the effects of consumption of diets low in advanced glycation end products (AGEs) on cardiometabolic parameters are conflicting. Hence, we performed a meta-analysis to determine the effect of low AGE diets in reducing cardiometabolic risk factors. Seventeen randomised controlled trials comprising 560 participants were included. Meta-analyses using random effects models were used to analyse the data. Low AGE diets decreased insulin resistance (mean difference [MD] -1.3, 95% CI -2.3, -0.2), total cholesterol (MD -8.5 mg/dl, 95% CI -9.5, -7.4) and low-density lipoprotein (MD -2.4 mg/dl, 95% CI -3.4, -1.3). There were no changes in weight, fasting glucose, 2-h glucose and insulin, haemoglobin A1c, high-density lipoprotein or blood pressure. In a subgroup of patients with type 2 diabetes, a decrease in fasting insulin (MD -7 mu U/ml, 95% CI -11.5, -2.5) was observed. Tumour necrosis factor alpha, vascular cell adhesion molecule-1, 8-isoprostane, leptin, circulating AGEs and receptor for AGEs were reduced after consumption of low AGE diets with increased adiponectin and sirtuin-1. Our findings suggest that diets low in AGEs may be an effective strategy for improving cardiometabolic profiles in individuals with and without type 2 diabetes.
C1 [Baye, Estifanos; Kiriakova, Velislava; Moran, Lisa J.; de Courten, Barbora] Monash Univ, Sch Publ Hlth & Prevent Med, Monash Ctr Hlth Res & Implementat, 43-51 Kanooka Grove, Clayton, Vic 3168, Australia.
   [Uribarri, Jaime] Mt Sinai Sch Med, Dept Med, One Gustave Levy Pl, New York, NY 10029 USA.
C3 Monash University; Icahn School of Medicine at Mount Sinai
RP de Courten, B (corresponding author), Monash Univ, Sch Publ Hlth & Prevent Med, Monash Ctr Hlth Res & Implementat, 43-51 Kanooka Grove, Clayton, Vic 3168, Australia.
EM barbora.decourten@monash.edu
RI de Courten, Barbora/B-3308-2012; Moran, Lisa/E-9850-2015; Uribarri,
   Jaime/ADX-7655-2022
OI uribarri, jaime/0000-0001-9826-1134; Baye,
   Estifanos/0000-0002-2937-356X; Moran, Lisa/0000-0001-5772-6484
FU Monash Graduate Scholarship; Monash International Postgraduate
   Scholarship; National Heart Foundation Fellowship [100864]
FX E.B. is a recipient of Monash Graduate Scholarship and Monash
   International Postgraduate Scholarship. B.d.C. is supported by a
   National Heart Foundation Fellowship (100864).
CR [Anonymous], TOUCH MED MEDIA
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NR 41
TC 58
Z9 60
U1 1
U2 14
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD MAY 23
PY 2017
VL 7
AR 2266
DI 10.1038/s41598-017-02268-0
PG 9
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA EV5ZD
UT WOS:000401847800012
PM 28536448
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Zhang, YY
   Jelleschitz, J
   Grune, T
   Chen, WX
   Zhao, YH
   Jia, MZ
   Wang, YJ
   Liu, ZG
   Höhn, A
AF Zhang, Yuyu
   Jelleschitz, Julia
   Grune, Tilman
   Chen, Weixuan
   Zhao, Yihang
   Jia, Mengzhen
   Wang, Yajie
   Liu, Zhigang
   Hoehn, Annika
TI Methionine restriction- Association with redox homeostasis and
   implications on aging and diseases
SO REDOX BIOLOGY
LA English
DT Article
DE Methionine restriction; Redox homeostasis; Aging; Metabolic syndrome;
   Cognitive disorders
ID PLASMA HOMOCYSTEINE CONCENTRATIONS; BRAIN INSULIN-RESISTANCE;
   HYDROGEN-SULFIDE PRODUCTION; LIFE-SPAN EXTENSION; GROWTH-FACTOR 21;
   OXIDATIVE STRESS; AMINO-ACIDS; CARDIOVASCULAR-DISEASE; CALORIE
   RESTRICTION; GLUCOSE-HOMEOSTASIS
AB Methionine is an essential amino acid, involved in the promotion of growth, immunity, and regulation of energy metabolism. Over the decades, research has long focused on the beneficial effects of methionine supplementa-tion, while data on positive effects of methionine restriction (MR) were first published in 1993. MR is a low-methionine dietary intervention that has been reported to ameliorate aging and aging-related health concomi-tants and diseases, such as obesity, type 2 diabetes, and cognitive disorders. In addition, MR seems to be an approach to prolong lifespan which has been validated extensively in various animal models, such as Caeno-rhabditis elegans, Drosophila, yeast, and murine models. MR appears to be associated with a reduction in oxidative stress via so far mainly undiscovered mechanisms, and these changes in redox status appear to be one of the underlying mechanisms for lifespan extension and beneficial health effects. In the present review, the association of methionine metabolism pathways with redox homeostasis is described. In addition, the effects of MR on lifespan, age-related implications, comorbidities, and diseases are discussed.
C1 [Zhang, Yuyu; Chen, Weixuan; Zhao, Yihang; Jia, Mengzhen; Wang, Yajie; Liu, Zhigang] Northwest A&F Univ, Coll Food Sci & Engn, Lab Funct Chem & Nutr Food, Yangling 712100, Shaanxi, Peoples R China.
   [Jelleschitz, Julia; Grune, Tilman; Liu, Zhigang; Hoehn, Annika] German Inst Human Nutr DIfE Potsdam Rehbruecke, Dept Mol Toxicol, Arthur Scheunert Allee 114-116, D-14558 Nuthetal, Germany.
   [Grune, Tilman; Hoehn, Annika] German Ctr Diabet Res DZD, D-85764 Munich, Germany.
   [Grune, Tilman] NutriAct Competence Cluster Nutr Res Berlin Potsd, Nuthetal, Germany.
   [Grune, Tilman] German Ctr Cardiovasc Res DZHK, Berlin, Germany.
   [Grune, Tilman] Univ Potsdam, Inst Nutr, D-14558 Nuthetal, Germany.
C3 Northwest A&F University - China; Leibniz Association; Deutsches
   Institut fur Ernahrungsforschung Potsdam-Rehbrucke (DIfE); German Center
   for Diabetes Research (DZD); German Centre for Cardiovascular Research
RP Liu, ZG (corresponding author), Northwest A&F Univ, Coll Food Sci & Engn, Lab Funct Chem & Nutr Food, Yangling 712100, Shaanxi, Peoples R China.; Liu, ZG; Höhn, A (corresponding author), German Inst Human Nutr DIfE Potsdam Rehbruecke, Dept Mol Toxicol, Arthur Scheunert Allee 114-116, D-14558 Nuthetal, Germany.
EM zhigangliu@nwsuaf.edu.cn
RI Liu, Zhigang/H-4818-2016; Zhang, Yuyu/KSM-3060-2024; zhao,
   yihang/KCY-4598-2024
OI Hohn, Annika/0000-0003-1306-2668
FU National Natural Science Foundation of China [81871118, 81803231];
   Alexander von Humboldt-Stiftung in Germany; German Ministry of Education
   and Research (BMBF); State of Brandenburg [DZD03D03]; Deutsche
   Forschungsgemeinschaft (DFG, German Research Foundation)
FX The authors Yuyu Zhang, Julia Jelleschitz, Tilman Grune, Weixuan Chen,
   Yihang Zhao, Mengzhen Jia, Yajie Wang, Zhigang Liu and Annika Ho ? hn
   declare no conflict of interest. Zhigang Liu was financially supported
   by the National Natural Sci- ence Foundation of China (Nos. 81871118 and
   81803231) and funded by the Alexander von Humboldt-Stiftung in Germany.
   Annika Ho ? hn was funded by the German Ministry of Education and
   Research (BMBF) and the State of Brandenburg (DZD grant DZD03D03) and by
   the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) .
   Tilman Grune was funded by the German Ministry of Education and Research
   (BMBF) and the State of Brandenburg (DZD grant DZD03D03) .
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NR 264
TC 29
Z9 31
U1 5
U2 49
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2213-2317
J9 REDOX BIOL
JI Redox Biol.
PD NOV
PY 2022
VL 57
AR 102464
DI 10.1016/j.redox.2022.102464
EA SEP 2022
PG 18
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 5A0KW
UT WOS:000862586600005
PM 36152485
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Rakshit, K
   Qian, J
   Colwell, CS
   Matveyenko, AV
AF Rakshit, K.
   Qian, J.
   Colwell, C. S.
   Matveyenko, A. V.
TI The islet circadian clock: entrainment mechanisms, function and role in
   glucose homeostasis
SO DIABETES OBESITY & METABOLISM
LA English
DT Review
DE -cell; circadian clock; circadian disruption; insulin secretion; islet;
   T2DM
ID BETA-CELL FAILURE; INSULIN-SECRETION; ACCELERATES DEVELOPMENT;
   DIURNAL-VARIATION; OXIDATIVE STRESS; SLEEP DURATION; METABOLISM;
   DISRUPTION; TOLERANCE; RHYTHMS
AB Circadian regulation of glucose homeostasis and insulin secretion has long been appreciated as an important feature of metabolic control in humans. Circadian disruption is becoming increasingly prevalent in today's society and is likely responsible in part for the considerable rise in type 2 diabetes (T2DM) and metabolic syndrome worldwide. Thus, understanding molecular mechanisms driving the inter-relationship between circadian disruption and T2DM is important in context of disease prevention and therapeutics. In this regard, the goal of this article is to highlight the role of the circadian system, and islet circadian clocks in particular, as potential regulators of -cell function and survival. To date, studies have shown that islet clocks respond to changes in feeding patterns, and regulate a multitude of critical cellular processes in insulin secreting -cells (e.g. insulin exocytosis, mitochondrial function and response to oxidative stress). Subsequently, either genetic or environmental disruption of normal islet clock performance compromises -cell function and leads to loss of glycaemic control. Future work is warranted to further unravel the role of circadian clocks in human islet function in health and contributions to pathogenesis of T2DM.
C1 [Rakshit, K.; Matveyenko, A. V.] Mayo Clin, Sch Med, Dept Physiol & Biomed Engn, Rochester, MN 55905 USA.
   [Qian, J.; Colwell, C. S.] Univ Calif Los Angeles, David Geffen Sch Med, Dept Psychiat & Biobehav Sci, Lab Circadian & Sleep Med, Los Angeles, CA 90095 USA.
C3 Mayo Clinic; University of California System; University of California
   Los Angeles; University of California Los Angeles Medical Center; David
   Geffen School of Medicine at UCLA
RP Matveyenko, AV (corresponding author), Mayo Clin, Sch Med, Dept Physiol & Biomed Engn, 200 First St SW, Rochester, MN 55905 USA.
EM Matveyenko.Aleksey@mayo.edu
RI Colwell, Chris/AAM-6111-2020
OI Colwell, Christopher/0000-0002-1059-184X; Qian,
   Jingyi/0000-0002-8793-9330
FU National Institutes of Health [DK098468]; O'Keefe Foundation; Center for
   Regenerative Medicine (Mayo Clinic, Rochester, MN)
FX We acknowledge funding support from the National Institutes of Health
   (DK098468 to A. V. M.), the O'Keefe Foundation (C. S. C. and A. V. M.)
   and the Center for Regenerative Medicine (Mayo Clinic, Rochester, MN).
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NR 73
TC 25
Z9 26
U1 0
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1462-8902
EI 1463-1326
J9 DIABETES OBES METAB
JI Diabetes Obes. Metab.
PD SEP
PY 2015
VL 17
SU 1
BP 115
EP 122
DI 10.1111/dom.12523
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA CQ7GF
UT WOS:000360770300017
PM 26332976
OA Bronze, Green Accepted, Green Submitted
DA 2025-06-11
ER

PT J
AU Xu, Y
   An, ZM
   Wang, SF
   Ni, YM
   Zhou, MM
   Feng, Q
   Gou, XJ
   Xu, ML
   Qi, Y
AF Xu, Yuan
   An, Ziming
   Wang, Shufei
   Ni, Yiming
   Zhou, Mingmei
   Feng, Qin
   Gou, Xiaojun
   Xu, Meiling
   Qi, Ying
TI Dual Role of Pregnane X Receptor in Nonalcoholic Fatty Liver Disease
SO CURRENT MOLECULAR PHARMACOLOGY
LA English
DT Review
DE Pregnane X receptor (PXR); Nuclear receptor; Nonalcoholic fatty liver
   disease; Nonalcoholic steatohepatitis; Metabolism; LCA.
ID ENDOPLASMIC-RETICULUM STRESS; REGULATES DRUG-METABOLISM; XENOBIOTIC
   RECEPTOR; NLRP3 INFLAMMASOME; NUCLEAR RECEPTORS; CROSS-TALK;
   GLUCOSE-HOMEOSTASIS; OXIDATIVE STRESS; LIPID-METABOLISM; GENE-EXPRESSION
AB The incidence of nonalcoholic fatty liver disease (NAFLD) has been rising worldwide in parallel with diabetes and metabolic syndrome. NAFLD refers to a spectrum of liver abnormalities with a variable course, ranging from nonalcoholic fatty liver (NAFL) to nonalcoholic steatohepatitis (NASH), eventually leading to cirrhosis and hepatocellular carcinoma. Pregnane X receptor (PXR), a member of the nuclear receptor superfamily, plays a prominent part in the regulation of endogenous metabolic genes in NAFLD. Recent studies have suggested that PXR has therapeutic potential for NAFLD, yet the relationship between PXR and NAFLD remains controversial. In this review, PXR is proposed to play a dual role in the development and progression of NAFLD. Its activation will aggravate steatosis of the liver, reduce inflammatory response, and prevent liver fibrosis. In addition, the interactions between PXR, substance metabolism, inflammation, fibrosis, and gut microbiota in non-alcoholic fatty liver were elucidated. Due to limited therapeutic options, a better understanding of the contribution of PXR to the pathogenesis of NAFLD should facilitate the design of innovative drugs targeting NAFLD.
C1 [Xu, Yuan; Wang, Shufei] Shaanxi Univ Chinese Med, Sch Pharm, Dept Pharmacol, Xianyang 712046, Shaanxi, Peoples R China.
   [An, Ziming; Feng, Qin] Shanghai Univ Tradit Chinese Med, Inst Liver Dis, Shuguang Hosp, Shanghai 201203, Peoples R China.
   [Ni, Yiming; Zhou, Mingmei] Shanghai Univ Tradit Chinese Med, Inst Interdisciplinary Integrat Med Res, Shanghai 201203, Peoples R China.
   [Gou, Xiaojun] Shanghai Univ Tradit Chinese Med, Baoshan Dist Hosp Integrated Tradit Chinese & Wes, Cent Lab, Shanghai 201999, Peoples R China.
   [Xu, Meiling] Chongqing Univ Cent Hosp, Chongqing Emergency Med Ctr, Chongqing 400014, Peoples R China.
   [Qi, Ying] Hangzhou Normal Univ, Sch Basic Med Sci, Hangzhou 311121, Peoples R China.
C3 Shaanxi University of Chinese Medicine; Shanghai University of
   Traditional Chinese Medicine; Shanghai University of Traditional Chinese
   Medicine; Shanghai University of Traditional Chinese Medicine; Hangzhou
   Normal University
RP Zhou, MM; Feng, Q; Gou, XJ (corresponding author), Shanghai Univ Tradit Chinese Med, Baoshan Dist Hosp Integrated Tradit Chinese & Wes, Youyi Branch Rd, Shanghai, Peoples R China.
EM zhoumm368@163.com; fengqin1227@163.com; gouxiaojun1975@163.com
FU National Natural Science Foundation [82074083]; District Level Medical
   and Health Key Project of Shanghai Baoshan District Science and
   Technology Commission Science, Technology Innovation Special Fund
   Project [21-E-63]; Zhejiang Province Basic Public Welfare Research
   Program Project [LY20C060002]; General Project of Shanghai Natural
   Science Foundation [23ZR1447600]; Basic Research and Frontier
   Exploration Project of Yuzhong District, Chongqing [20210175]
FX This study was financially supported by the National Natural Science
   Foundation (No. 82074083), District Level Medical and Health Key Project
   of Shanghai Baoshan District Science and Technology Commission Science,
   Technology Innovation Special Fund Project (21-E-63), the Zhejiang
   Province Basic Public Welfare Research Program Project (LY20C060002),
   the General Project of Shanghai Natural Science Foundation
   (23ZR1447600), and the Basic Research and Frontier Exploration Project
   of Yuzhong District, Chongqing (20210175).
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NR 206
TC 3
Z9 3
U1 4
U2 13
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1874-4672
EI 1874-4702
J9 CURR MOL PHARMACOL
JI Curr. Molec. Pharmacol.
PY 2024
VL 17
DI 10.2174/0118761429259143230927110556
PG 17
WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
GA IC3J2
UT WOS:001164081900027
PM 37936450
OA hybrid
DA 2025-06-11
ER

PT J
AU Kakimoto, PA
   Serna, JDC
   Ramos, VD
   Zorzano, A
   Kowaltowski, AJ
AF Kakimoto, Pamela A.
   Serna, Julian David C.
   Ramos, Vitor de Miranda
   Zorzano, Antonio
   Kowaltowski, Alicia J.
TI Increased glycolysis is an early consequence of palmitate lipotoxicity
   mediated by redox signaling
SO REDOX BIOLOGY
LA English
DT Article
DE Palmitic acid; Mitochondria; Glycolysis; Oxidative stress; Reactive
   oxygen species
ID FATTY LIVER-DISEASE; NADPH OXIDASE; MITOCHONDRIAL DYSFUNCTION;
   SUPEROXIDE-PRODUCTION; OXIDATIVE STRESS; DYNAMICS; GLUCOSE; SUPPRESSORS;
   METABOLISM; ACTIVATION
AB Exposure to toxic levels of fatty acids (lipotoxicity) leads to cell damage and death and is involved in the pathogenesis of the metabolic syndrome. Since the metabolic consequences of lipotoxicity are still poorly understood, we studied the bioenergetic effects of the saturated fatty acid palmitate, quantifying changes in mitochondrial morphology, real-time oxygen consumption, ATP production sources, and extracellular acidification in hepatoma cells. Surprisingly, glycolysis was enhanced by the presence of palmitate as soon as 1 h after stimulus, while oxygen consumption and oxidative phosphorylation were unchanged, despite overt mitochondrial fragmentation. Palmitate only induced mitochondrial fragmentation if glucose and glutamine were available, while glycolytic enhancement did not require glutamine, showing it is independent of mitochondrial morphological changes. Redox state was altered by palmitate, as indicated by NAD(P)H quantification. Furthermore, the mitochondrial antioxidant mitoquinone, or a selective inhibitor of complex I electron leakage (S1QEL) further enhanced palmitate-induced glycolysis. Our results demonstrate that palmitate overload and lipotoxicity involves an unexpected and early increase in glycolytic flux, while, surprisingly, no changes in oxidative phosphorylation are observed. Interestingly, enhanced glycolysis involves signaling by mitochondrially-generated oxidants, uncovering a novel regulatory mechanism for this pathway.
C1 [Kakimoto, Pamela A.; Serna, Julian David C.; Ramos, Vitor de Miranda; Kowaltowski, Alicia J.] Univ Sao Paulo, Dept Bioquim, Inst Quim, Sao Paulo, Brazil.
   [Zorzano, Antonio] Univ Barcelona, CIBER Diabet & Enfermedades Metab Asociadas CIBER, Inst Res Biomed IRB Barcelona,Fac Biol, Inst Salud Carlos III,Dept Bioquim & Biomed Mol, Barcelona, Spain.
C3 Universidade de Sao Paulo; Barcelona Institute of Science & Technology;
   Institute for Research in Biomedicine - IRB Barcelona; University of
   Barcelona; CIBER - Centro de Investigacion Biomedica en Red; CIBERES;
   Instituto de Salud Carlos III
RP Kakimoto, PA; Kowaltowski, AJ (corresponding author), Ave Prof Lineu Prestes 748,Cidade Univ, BR-05508000 Sao Paulo, SP, Brazil.
EM pamela.kakimoto@gmail.com; alicia@iq.usp.br
RI RAMOS, VITOR/W-1811-2019; Kowaltowski, Alicia/H-8698-2012
OI Cualcialpud Serna, Julian David/0000-0002-2285-5769; Kowaltowski,
   Alicia/0000-0002-3807-2419; de Miranda Ramos, Vitor/0000-0001-7004-0823
FU Centro de Pesquisa, Inovacao e Difusao de Processos Redox em Biomedicina
   (CEPID Redoxoma) grant [2013/07937-8]; Fundacao de Amparo a Pesquisa do
   Estado de Sao Paulo (FAPESP) [2015/25862-0, 2019/05226-3, 2019/18402-4];
   MINECO [SAF2016-75246R]; Generalitat de Catalunya [2017SGR1015];
   CIBERDEM ("Instituto de Salud Carlos III"); Fundacion Ramon Areces
   [CIVP18A3942]; Fundacion BBVA; Fundacio Marato de TV3 [20132330]; CAPES
FX This work was funded by Centro de Pesquisa, Inovacao e Difusao de
   Processos Redox em Biomedicina (CEPID Redoxoma) grant 2013/07937-8,
   Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) grants
   2015/25862-0, 2019/05226-3, 2019/18402-4, MINECO (SAF2016-75246R), the
   Generalitat de Catalunya (Grant 2017SGR1015), CIBERDEM ("Instituto de
   Salud Carlos III"), the Fundacion Ramon Areces (CIVP18A3942), the
   Fundacion BBVA, Fundacio Marato de TV3 (20132330), and CAPES, with no
   involvement of the funding agencies in the design of this study.
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NR 64
TC 29
Z9 29
U1 0
U2 19
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2213-2317
J9 REDOX BIOL
JI Redox Biol.
PD SEP
PY 2021
VL 45
AR 102026
DI 10.1016/j.redox.2021.102026
EA JUN 2021
PG 12
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA TI1KM
UT WOS:000672541300002
PM 34102573
OA Green Accepted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Baffy, G
AF Baffy, G
TI Uncoupling protein-2 and non-alcoholic fatty liver disease
SO FRONTIERS IN BIOSCIENCE-LANDMARK
LA English
DT Review
DE uncoupling protein-2; mitochondria; electron transport chain; oxidative
   phosphorylation; proton leak; mitochondrial membrane potential; reactive
   oxygen species; fatty acids; AMP-activated kinase; non-alcoholic fatty
   liver disease; non-alcoholic steatohepatitis; cryptogenic cirrhosis;
   hepatocellular cancer; review
ID MITOCHONDRIAL RESPIRATORY-CHAIN; OXYGEN SPECIES PRODUCTION;
   ELECTRON-TRANSPORT CHAIN; TUMOR-NECROSIS-FACTOR; INSULIN-RESISTANCE;
   OXIDATIVE STRESS; HEPATIC STEATOSIS; UP-REGULATION; OBESE MICE;
   RAT-LIVER
AB Non-alcoholic fatty liver disease (NAFLD) has become the most common form of hepatic disorders in the developed world. NAFLD is part of the metabolic syndrome with insulin resistance as a primary underlying derangement. The natural history of NAFLD may extend from simple steatosis over steatohepatitis into cirrhosis and hepatocellular carcinoma. Among numerous factors shaping these transitions, uncoupling protein-2 (UCP2) may theoretically contribute to every stage of this disease. UCP2 is a recently identified fatty acid-responsive mitochondrial inner membrane carrier protein showing wide tissue distribution with a substantially increased presence in fatty liver. The biological functions of UCP2 are not fully elucidated and the greater part of our current knowledge has been obtained from animal experiments. These data suggest a role for UCP2 in lipid metabolism, mitochondrial bioenergetics, oxidative stress, apoptosis, and even carcinogenesis. Available evidence is reviewed and new concepts are considered to appraise the potential role of UCP2 in the pathogenesis of NAFLD.
C1 Rhode Isl Hosp, Liver Res Ctr, Div Gastroenterol, Providence, RI 02903 USA.
   Brown Univ, Sch Med, Providence, RI 02903 USA.
C3 Lifespan Health Rhode Island; Rhode Island Hospital; Brown University
RP Liver Res Ctr, 55 Claverick St,Room 413, Providence, RI 02903 USA.
EM gbaffy@brown.edu
RI Baffy, Gyorgy/P-7986-2018
OI Baffy, Gyorgy/0000-0002-8334-0400
FU NCRR NIH HHS [RR-17695] Funding Source: Medline; NIDDK NIH HHS
   [DK-61890] Funding Source: Medline
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NR 141
TC 61
Z9 67
U1 0
U2 12
PU FRONTIERS IN BIOSCIENCE INC
PI IRVINE
PA 16471 SCIENTIFIC WAY, IRVINE, CA 92618 USA
SN 1093-9946
EI 1093-4715
J9 FRONT BIOSCI-LANDMRK
JI Front. Biosci.
PD SEP 1
PY 2005
VL 10
SU S
BP 2082
EP 2096
DI 10.2741/1683
PG 15
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA 970OU
UT WOS:000232320300010
PM 15970480
OA Green Submitted, Bronze
DA 2025-06-11
ER

PT J
AU Dozio, E
   Maffioli, E
   Vianello, E
   Nonnis, S
   Scalvini, FG
   Spatola, L
   Roccabianca, P
   Tedeschi, G
   Romanelli, MMC
AF Dozio, Elena
   Maffioli, Elisa
   Vianello, Elena
   Nonnis, Simona
   Grassi Scalvini, Francesca
   Spatola, Leonardo
   Roccabianca, Paola
   Tedeschi, Gabriella
   Corsi Romanelli, Massimiliano Marco
TI A Wide-Proteome Analysis to Identify Molecular Pathways Involved in
   Kidney Response to High-Fat Diet in Mice
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE cardiometabolic risk; fibrosis; high-fat diet; kidney; lipids; obesity;
   proteomic analysis; renal damage
ID LIPID-ACCUMULATION; OBESITY; DISEASE; METABOLISM; ACID; OXIDATION;
   PROMOTES; STRESS; KINASE; CD36
AB The etiopathogenesis of obesity-related chronic kidney disease (CKD) is still scarcely understood. To this aim, we assessed the effect of high-fat diet (HF) on molecular pathways leading to organ damage, steatosis, and fibrosis. Six-week-old male C57BL/6N mice were fed HF diet or normal chow for 20 weeks. Kidneys were collected for genomic, proteomic, histological studies, and lipid quantification. The main findings were as follows: (1) HF diet activated specific pathways leading to fibrosis and increased fatty acid metabolism; (2) HF diet promoted a metabolic shift of lipid metabolism from peroxisomes to mitochondria; (3) no signs of lipid accumulation and/or fibrosis were observed, histologically; (4) the early signs of kidney damage seemed to be related to changes in membrane protein expression; (5) the proto-oncogene MYC was one of the upstream transcriptional regulators of changes occurring in protein expression. These results demonstrated the potential usefulness of specific selected molecules as early markers of renal injury in HF, while histomorphological changes become visible later in obesity-related CDK. The integration of these information with data from biological fluids could help the identification of biomarkers useful for the early detection and prevention of tissue damage in clinical practice.
C1 [Dozio, Elena; Vianello, Elena; Corsi Romanelli, Massimiliano Marco] Univ Milan, Dept Biomed Sci Hlth, Clin Pathol Lab, I-20133 Milan, Italy.
   [Maffioli, Elisa; Nonnis, Simona; Grassi Scalvini, Francesca; Roccabianca, Paola; Tedeschi, Gabriella] Univ Milan, Dept Vet Med & Anim Sci, I-26900 Lodi, Italy.
   [Nonnis, Simona; Tedeschi, Gabriella] Univ Milan, CRC Innovat Well Being & Environm I WE, I-29133 Milan, Italy.
   [Spatola, Leonardo] ASST Grande Osped Metropolitano Niguarda, Div Nephrol Dialysis & Renal Transplantat, I-20162 Milan, Italy.
   [Corsi Romanelli, Massimiliano Marco] IRCCS Policlin San Donato, Serv Lab Med 1 Clin Pathol, I-20097 San Donato Milanese, Italy.
C3 University of Milan; University of Milan; University of Milan; IRCCS
   Policlinico San Donato
RP Vianello, E (corresponding author), Univ Milan, Dept Biomed Sci Hlth, Clin Pathol Lab, I-20133 Milan, Italy.
EM elena.dozio@unimi.it; elisa.maffioli@unimi.it; elena.vianello@unimi.it;
   simona.nonnis@unimi.it; francesca.grassiscalvini@unimi.it;
   leonardospatola@yahoo.it; paola.roccabianca@unimi.it;
   gabriella.tedeschi@unimi.it; mmcorsi@unimi.it
RI Nonnis, Simona/I-6198-2017; Dozio, Elena/ABG-3014-2020; Maffioli,
   Elisa/U-5511-2017; Corsi Romanelli, Massimiliano Marco/K-9359-2016;
   ROCCABIANCA, PAOLA/I-6110-2017; VIANELLO, ELENA/ABJ-5039-2022
OI DOZIO, ELENA/0000-0001-5833-0780; NONNIS, SIMONA/0000-0002-3453-7282;
   Corsi Romanelli, Massimiliano Marco/0000-0001-7928-7697; ROCCABIANCA,
   PAOLA/0000-0002-3672-4612; VIANELLO, ELENA/0000-0001-6461-654X; Spatola,
   Leonardo/0000-0002-8883-4776
FU Universita degli Studi di Milano [Linea 2, PSR2017_Dozio, Linea
   2_PSR2020_Dozio]; Italian Ministry for Health "Ricerca Corrente"
   I.R.C.C.S. Policlinico San Donato
FX This research was supported by funds from the Universita degli Studi di
   Milano (Linea 2, PSR2017_Dozio, Linea 2_PSR2020_Dozio) and the Italian
   Ministry for Health "Ricerca Corrente" I.R.C.C.S. Policlinico San
   Donato. We thank the OMICS facility of the University of Milano for mass
   spectrometry raw data acquisition.
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NR 46
TC 3
Z9 3
U1 0
U2 4
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD APR
PY 2022
VL 23
IS 7
AR 3809
DI 10.3390/ijms23073809
PG 20
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 0M3VZ
UT WOS:000782087300001
PM 35409168
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Hu, HC
   Lin, Y
   Xu, XF
   Lin, SY
   Chen, XM
   Wang, SS
AF Hu, Haochang
   Lin, Ying
   Xu, Xiaofeng
   Lin, Shaoyi
   Chen, Xiaomin
   Wang, Shuangshuang
TI The alterations of mitochondrial DNA in coronary heart disease
SO EXPERIMENTAL AND MOLECULAR PATHOLOGY
LA English
DT Review
DE Mitochondrial DNA mutations; Altered copy number of mitochondrial DNA;
   mtDNA haplogroups; Reactive oxygen species; Atherosclerosis; Coronary
   heart disease
ID 4977 BP DELETION; COPY NUMBER; OXIDATIVE STRESS; MYOCARDIAL-INFARCTION;
   METABOLIC SYNDROME; ARTERY-DISEASE; BLOOD-CELLS; CARDIOVASCULAR-DISEASE;
   THERAPEUTIC TARGET; CLINICAL-FEATURES
AB Coronary heart disease (CHD) is the major cause of death in modern society. CHD is characterized by atherosclerosis, which could lead to vascular cavity stenosis or obstruction, resulting in ischemic cardiac conditions such as angina and myocardial infarction. In terms of the mitochondrion, the main function is to produce adenosine triphosphate (ATP) for cells. And the alterations (including mutations, altered copy number and haplogroups) of mitochondrial DNA (mtDNA) are associated with the abnormal expression of oxidative phosphorylation (OXPHOS) system, resulting in mitochondrial dysfunction, then leading to perturbation on the electron transport chain and increased ROS generation and reduction in ATP level, contributing to ATP-producing disorders and oxidative stress, which may further accelerate development or vulnerability of atherosclerosis and myocardial ischemic injury. Therefore, the mtDNA defects may play an important role in making an early diagnosis, identifying disease-specific biomarkers and therapeutic targets, and predicting outcomes for patients with atherosclerosis and CHD. In this review, we aim to summarize the contribution of mtDNA mutations, altered mtDNA copy number and mtDNA haplogroups on the occurrence and development of CHD.
C1 [Hu, Haochang; Lin, Ying; Xu, Xiaofeng] Ningbo Univ, Sch Med, Ningbo, Zhejiang, Peoples R China.
   [Lin, Shaoyi; Chen, Xiaomin; Wang, Shuangshuang] Ningbo First Hosp, Dept Cardiol, Ningbo, Zhejiang, Peoples R China.
C3 Ningbo University; Ningbo University
RP Chen, XM; Wang, SS (corresponding author), Ningbo First Hosp, Dept Cardiol, Ningbo, Zhejiang, Peoples R China.
EM cxmdoctor@126.com; wangss1023@126.com
RI chen, xiaomin/LLL-2939-2024; Xu, Xiaofeng/AAK-7567-2021; Wang,
   Shuangshuang/ABE-9819-2020
FU Natural Science Foundation of Zhejiang Province [Q19H020010,
   LY19H020003]; Natural Science Foundation of Ningbo [2018A610418,
   2017A610209]
FX The research was supported by the grants from: Natural Science
   Foundation of Zhejiang Province (Q19H020010, LY19H020003), Natural
   Science Foundation of Ningbo (2018A610418, 2017A610209).
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NR 143
TC 37
Z9 42
U1 2
U2 20
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0014-4800
EI 1096-0945
J9 EXP MOL PATHOL
JI Exp. Mol. Pathol.
PD JUN
PY 2020
VL 114
AR 104412
DI 10.1016/j.yexmp.2020.104412
PG 8
WC Pathology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pathology
GA LO4VD
UT WOS:000533626500025
PM 32113905
DA 2025-06-11
ER

PT J
AU Uusitupa, M
   Schwab, U
AF Uusitupa, Matti
   Schwab, Ursula
TI Diet, Inflammation and Prediabetes-Impact of Quality of Diet
SO CANADIAN JOURNAL OF DIABETES
LA English
DT Review
DE diabetes; diet; IL-1Ra; inflammation; prediabetes; prevention
ID INTERLEUKIN-1 RECEPTOR ANTAGONIST; LIFE-STYLE INTERVENTION;
   FINNISH-DIABETES-PREVENTION; ADIPOSE-TISSUE; INSULIN-RESISTANCE;
   METABOLIC SYNDROME; GENE-EXPRESSION; FOLLOW-UP; MARKERS; OBESITY
AB Low grade inflammation has been linked to risk of type 2 diabetes and atherosclerotic vascular diseases. Obesity and, in particular, abdominal obesity increase the risk of diabetes and atherosclerotic vascular diseases. One of the mechanisms could be low grade inflammation and vascular endothelial dysfunction. Permanent weight reduction is the first line of treatment both for obese individuals at increased risk of diabetes and for newly onset type 2 diabetes. Weight reduction lowers the level of several inflammatory factors in the body while increasing the level of adiponectin. Besides weight reduction the quality of diet and physical activity also modifies low grade inflammation. Based on the literature survey and our own studies in humans, it is possible to have dietary patterns that reduce inflammatory stress in the body and improves vascular endothelial dysfunction. There is strong evidence to suggest that IL-1 Ra is a very sensitive marker of low grade inflammation in obesity and related phenotypes; however, its level is markedly lowered by weight reduction and by choosing foods that have been shown to reduce inflammatory stress in the body. (C) 2013 Canadian Diabetes Association
C1 [Uusitupa, Matti; Schwab, Ursula] Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio 70211, Finland.
   [Uusitupa, Matti] Kuopio Univ Hosp, Res Unit, SF-70210 Kuopio, Finland.
   [Schwab, Ursula] Kuopio Univ Hosp, Inst Med, SF-70210 Kuopio, Finland.
C3 University of Eastern Finland; University of Eastern Finland; University
   of Eastern Finland Hospital; Kuopio University Hospital; Kuopio
   University Hospital; University of Eastern Finland; University of
   Eastern Finland Hospital
RP Uusitupa, M (corresponding author), Univ Eastern Finland, POB 1627, Kuopio 70211, Finland.
EM matti.uusitupa@uef.fi
RI Uusitupa, Matti/AAX-4929-2020
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NR 50
TC 16
Z9 19
U1 0
U2 13
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1499-2671
EI 2352-3840
J9 CAN J DIABETES
JI Can. J. Diabetes
PD OCT
PY 2013
VL 37
IS 5
BP 327
EP 331
DI 10.1016/j.jcjd.2013.07.029
PG 5
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA AL8WC
UT WOS:000339419400009
PM 24500560
DA 2025-06-11
ER

PT J
AU Lee, SE
   Lee, EH
   Lee, TJ
   Kim, SW
   Kim, BH
AF Lee, Seong-Eun
   Lee, Eun-Hei
   Lee, Tae-Jong
   Kim, Seung-Won
   Kim, Bae-Hwan
TI Anti-Obesity Effect and Action Mechanism of Adenophora triphylla
   Root Ethanol Extract in C57BL/6 Obese Mice Fed a High-Fat Diet
SO BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
LA English
DT Article
DE anti-obesity; Adenophora triphylla; anti-inflammatory; anti-oxidative;
   C57BL/6
ID PREADIPOCYTE DIFFERENTIATION; INSULIN-RESISTANCE; OXIDATIVE STRESS;
   ADIPOCYTE SIZE; INFLAMMATION; SENSITIVITY; REDUCTION; PPARS
AB This study investigated the anti-obesity effect of Adenophora triphylla root ethanol extract (ATREE). C57BL/6 mice were divided into five groups, a normal diet group (N), a control group fed only high-fat diet (HFD) (C), a positive control group fed HFD with 0.5% catechin (PC), and groups fed HFD with 0.5% (E1) or 1% (E2) ATREE. The body weight gain, hematological and serum biochemistry data, and anti-oxidative index in the liver and epididymal adipose tissue were improved significantly in the E group (E1, E2), as compared to the C group. As for histological findings, adipocyte size was reduced by ATREE. E group (E1, E2) showed significant increases in adiponectin, AMPK, and PPAR-alpha, and significant decreases in TNF-alpha, GPDH, and PPAR-gamma, as compared to the C group. The above findings indicate that ATREE might have an anti-obesity effect through antioxidant and anti-inflammatory action. It is considered ATREE can be used as a natural treatment for obesity and metabolic syndrome induced by oxidative stress.
C1 [Lee, Seong-Eun; Lee, Eun-Hei; Kim, Seung-Won; Kim, Bae-Hwan] Keimyung Univ, Dept Publ Hlth, Taegu 704701, South Korea.
   [Lee, Tae-Jong] Daegu Fatima Hosp, Dept Pathol, Taegu 701600, South Korea.
C3 Keimyung University; Daegu Fatima Hospital
RP Kim, BH (corresponding author), Keimyung Univ, Dept Publ Hlth, 1095 Dalgubeoldaero, Taegu 704701, South Korea.
EM kim9399@kmu.ac.kr
RI Lee, Heejin/HTT-4810-2023; Kim, Seung/G-1843-2010; Lee, Hyo/G-6299-2019
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NR 38
TC 22
Z9 24
U1 0
U2 15
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0916-8451
EI 1347-6947
J9 BIOSCI BIOTECH BIOCH
JI Biosci. Biotechnol. Biochem.
PD MAR
PY 2013
VL 77
IS 3
BP 544
EP 550
DI 10.1271/bbb.120667
PG 7
WC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
   Chemistry, Applied; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
   Chemistry; Food Science & Technology
GA 132GK
UT WOS:000318055700014
PM 23470751
OA Bronze
DA 2025-06-11
ER

PT J
AU Liu, M
   Wu, KM
   Wu, YK
AF Liu, Min
   Wu, Keming
   Wu, Yeke
TI The emerging role of ferroptosis in female reproductive disorders
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Article
DE Ferroptosis; Female reproductive disorders; Iron metabolism; Lipid
   metabolism; Reactive oxygen species
ID BODY IRON STORES; OXIDATIVE STRESS; CELL-DEATH; CANCER-CELLS; PROMOTES
   FERROPTOSIS; INSULIN-RESISTANCE; METABOLIC SYNDROME; ISCHEMIC-STROKE;
   APOPTOSIS; OVERLOAD
AB Iron, as an essential trace element for the organism, is vital for maintaining the organism's health. Excessive iron can promote reactive oxygen species (ROS) accumulation, thus damaging cells and tissues. Ferroptosis is a novel form of programmed cell death distinguished by iron overload and lipid peroxidation, which is unique from autophagy, apoptosis and necrosis, more and more studies are focusing on ferroptosis. Recent evidence suggests that ferroptosis is associated with the development of female reproductive disorders (FRDs), including polycystic ovary syndrome (PCOS), premature ovarian insufficiency (POI), endometriosis (EMs), ovarian cancer (OC), preeclampsia (PE) and spontaneous abortion (SA). Pathways and genes associated with ferroptosis may participate in processes that regulate granulosa cell proliferation and secretion, oocyte development, ovarian reserve function, early embryonic development and placental oxidative stress. However, its exact mechanism has not been fully revealed. Therefore, our review systematically elaborates the occurrence mechanism of ferroptosis and its research progress in the development of FRDs, with a view to providing literature references for clinical targeting of ferroptosis -related pathways and regulatory factors for the management of FRDs.
C1 [Liu, Min; Wu, Keming] Hosp Chengdu Univ Tradit Chinese Med, Dept Gynecol, Chengdu 610032, Peoples R China.
   [Liu, Min; Wu, Keming] Chengdu Univ Tradit Chinese Med, Sch Clin Med, Dept Gynecol, Chengdu 610075, Peoples R China.
   [Wu, Yeke] Hosp Chengdu Univ Tradit Chinese Med, Dept Stomatol, Chengdu 610032, Peoples R China.
C3 Chengdu University of Traditional Chinese Medicine; Chengdu University
   of Traditional Chinese Medicine; Chengdu University of Traditional
   Chinese Medicine
RP Wu, KM (corresponding author), Hosp Chengdu Univ Tradit Chinese Med, Dept Gynecol, Chengdu 610032, Peoples R China.; Wu, YK (corresponding author), Hosp Chengdu Univ Tradit Chinese Med, Dept Stomatol, Chengdu 610032, Peoples R China.
EM wu_keming1@126.com; 337872366@qq.com
FU National Natural Science Foundation of China [81973684]; Natural Science
   Foundation of Sichuan Province [2023NSFSC1760]
FX <B>Acknowledgements</B> This work was supported by National Natural
   Science Foundation of China (No. 81973684) and Natural Science
   Foundation of Sichuan Province (No. 2023NSFSC1760) .
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NR 178
TC 44
Z9 45
U1 6
U2 44
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD OCT
PY 2023
VL 166
AR 115415
DI 10.1016/j.biopha.2023.115415
EA SEP 2023
PG 17
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA S9MA3
UT WOS:001074321600001
PM 37660655
OA gold
DA 2025-06-11
ER

PT J
AU Wang, C
   Jin, C
   Yin, XF
   Liu, JD
   Liu, JB
AF Wang, Chuan
   Jin, Chen
   Yin, Xiaofei
   Liu, Jidong
   Liu, Jinbo
TI Relationship between serum bilirubin concentration and sarcopenia in
   patients with type 2 diabetes: a cross-sectional study
SO JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
LA English
DT Article
DE Bilirubin; sarcopenia; type 2 diabetes mellitus; oxidative stress;
   indirect bilirubin; skeletal muscle mass
ID METABOLIC SYNDROME; PREVALENCE; MELLITUS
AB Objective
   The prevalence of sarcopenia is high in patients with type 2 diabetes mellitus (T2DM). Oxidative stress and inflammation play important roles in the pathogenesis of sarcopenia in diabetes. Bilirubin has been shown to possess anti-oxidative activity. We aimed to explore the relationship between bilirubin and sarcopenia in patients with T2DM.
   Methods
   A total of 251 patients (124 men and 127 postmenopausal women) with T2DM, aged >= 50 years, participated in a cross-sectional study. The serum concentrations of bilirubin (TBIL), direct bilirubin (DBIL) and indirect bilirubin (IBIL) were measured. Muscle mass was measured using dual-energy X-ray absorptiometry.
   Results
   TBIL and IBIL were positively associated with appendicular skeletal muscle mass index (SMI) in men, but not in women. After adjustment for multiple factors in multiple linear regression analysis, TBIL and IBIL were also significantly associated with SMI in men. In multiple logistic regression analysis, participants in the highest quartile of IBIL demonstrated a lower odds ratio for sarcopenia in men.
   Conclusions
   Both TBIL and IBIL are positively associated with muscle mass in men with T2DM. Furthermore, IBIL may protect against sarcopenia in men with T2DM.
C1 [Wang, Chuan; Yin, Xiaofei; Liu, Jidong; Liu, Jinbo] Shandong Univ, Cheeloo Coll Med, Qilu Hosp, Dept Endocrinol, Jinan, Peoples R China.
   [Wang, Chuan; Yin, Xiaofei; Liu, Jidong; Liu, Jinbo] Shandong Univ, Inst Endocrine & Metab Dis, Jinan, Peoples R China.
   [Wang, Chuan; Yin, Xiaofei; Liu, Jidong; Liu, Jinbo] Key Lab Endocrine & Metab Dis, Shandong Prov Med & Hlth, Jinan, Peoples R China.
   [Wang, Chuan; Yin, Xiaofei; Liu, Jidong; Liu, Jinbo] Jinan Clin Res Ctr Endocrine & Metab Dis, Jinan, Peoples R China.
   [Jin, Chen] Matern & Child Hlth Care Zaozhuang, Dept Endocrinol, Zaozhuang, Peoples R China.
C3 Shandong University; Shandong University
RP Liu, JB (corresponding author), Shandong Univ, Qilu Hosp, 107 Wenhuaxi Rd, Jinan 250012, Peoples R China.
EM jinboliu@sdu.edu.cn
RI jin, chen/KBQ-8592-2024
OI Liu, Jidong/0000-0002-1279-0279; Liu, Jinbo/0000-0002-5069-2450
FU National Natural Science Foundation of China [81700739]
FX The present study was supported by the National Natural Science
   Foundation of China (No. 81700739).
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NR 34
TC 7
Z9 7
U1 1
U2 13
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0300-0605
EI 1473-2300
J9 J INT MED RES
JI J. Int. Med. Res.
PD MAR
PY 2021
VL 49
IS 3
AR 03000605211004226
DI 10.1177/03000605211004226
PG 9
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA RH3SN
UT WOS:000636142900001
PM 33779353
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Fisslthaler, B
   Fleming, I
AF Fisslthaler, Beate
   Fleming, Ingrid
TI Activation and Signaling by the AMP-Activated Protein Kinase in
   Endothelial Cells
SO CIRCULATION RESEARCH
LA English
DT Review
DE angiogenesis; nitric oxide synthase; atherosclerosis;
   3-hydroxy-3-methylglutaryl coenzyme A; energy metabolism
ID NITRIC-OXIDE SYNTHASE; NF-KAPPA-B; FATTY-ACID OXIDATION; OXYGEN SPECIES
   PRODUCTION; STRESS-INDUCED ACTIVATION; COENZYME-A REDUCTASE;
   SKELETAL-MUSCLE; MESSENGER-RNA; IN-VIVO; INSULIN-RESISTANCE
AB The AMP-activated protein kinase (AMPK) was initially identified as the kinase that phosphorylates the 3-hydroxy 3-methylglutaryl coenzyme A reductase, the rate-limiting enzyme for cholesterol biosynthesis. As the name suggests, the AMPK is activated by increased intracellular concentrations of AMP, and is generally described as a "metabolite-sensing kinase" and when activated initiates steps to conserve cellular energy. Although there is a strong link between the activity of the AMPK and metabolic control in muscle cells, the activity of the AMPK in endothelial cells can be regulated by stimuli that affect cellular ATP levels, such as hypoxia as well as by fluid shear stress, Ca2+-elevating agonists, and hormones such as adiponectin. To date the AMPK in endothelial cells has been implicated in the regulation of fatty acid oxidation, small G protein activity and nitric oxide production as well as inflammation and angiogenesis. Moreover, there is evidence indicating that the activation of the AMPK may help to prevent the vascular complications associated with the metabolic syndrome. (Circ Res. 2009;105:114-127.)
C1 [Fisslthaler, Beate; Fleming, Ingrid] Goethe Univ Frankfurt, Ctr Mol Med, Inst Vasc Signalling, D-60590 Frankfurt, Germany.
C3 Goethe University Frankfurt
RP Fleming, I (corresponding author), Goethe Univ Frankfurt, Ctr Mol Med, Inst Vasc Signalling, Theodor Stern Kai 7, D-60590 Frankfurt, Germany.
EM fleming@em.uni-frankfurt.de
RI Fleming, Ingrid/L-1225-2014
OI Fleming, Ingrid/0000-0003-1881-3635
FU Deutsche Forschungsgemeinschaft (Exzellenzcluster 147 "Cardio-Pulmonary
   Systems")
FX Supported by the Deutsche Forschungsgemeinschaft (Exzellenzcluster 147
   "Cardio-Pulmonary Systems").
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NR 164
TC 263
Z9 284
U1 0
U2 17
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0009-7330
EI 1524-4571
J9 CIRC RES
JI Circ.Res.
PD JUL 17
PY 2009
VL 105
IS 2
BP 114
EP 127
DI 10.1161/CIRCRESAHA.109.201590
PG 14
WC Cardiac & Cardiovascular Systems; Hematology; Peripheral Vascular
   Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Hematology
GA 471IS
UT WOS:000268050900003
PM 19608989
OA Bronze
DA 2025-06-11
ER

PT J
AU Guyatt, AL
   Burrows, K
   Guthrie, PAI
   Ring, S
   McArdle, W
   Day, INM
   Ascione, R
   Lawlor, DA
   Gaunt, TR
   Rodriguez, S
AF Guyatt, Anna L.
   Burrows, Kimberley
   Guthrie, Philip A. I.
   Ring, Sue
   McArdle, Wendy
   Day, Ian N. M.
   Ascione, Raimondo
   Lawlor, Debbie A.
   Gaunt, Tom R.
   Rodriguez, Santiago
TI Cardiometabolic phenotypes and mitochondrial DNA copy number in two
   cohorts of UK women
SO MITOCHONDRION
LA English
DT Article
DE Mitochondrial DNA; Copy number; ALSPAC; Complex traits; Cardiovascular
   disease; Diabetes
ID CORONARY-HEART-DISEASE; PERIPHERAL-BLOOD; SKELETAL-MUSCLE; TELOMERE
   LENGTH; ASSOCIATION; RISK; DELETION; CELLS; MTDNA; AGE
AB The mitochondrial genome is present at variable copy number between individuals. Mitochondria are vulnerable to oxidative stress, and their dysfunction may be associated with cardiovascular disease.
   The association of mitochondrial DNA copy number with cardiometabolic risk factors (lipids, glycaemic traits, inflammatory markers, anthropometry and blood pressure) was assessed in two independent cohorts of European origin women, one in whom outcomes were measured at mean (SD) age 30 (4.3) years (N = 2278) and the second at 69.4 (5.5) years (N = 2872). Mitochondrial DNA copy number was assayed by quantitative polymerase chain reaction. Associations were adjusted for smoking, sociodemographic status, laboratory factors and white cell traits.
   Out of a total of 12 outcomes assessed in both cohorts, mitochondrial DNA copy number showed little or no association with the majority (point estimates were close to zero and nearly all p-values were > 0.01). The strongest evidence was for an inverse association in the older cohort with insulin (standardised beta [95%CI]: 0.06, [0.098, 0.022], p = 0.002), but this association did not replicate in the younger cohort.
   Our findings do not provide support for variation in mitochondrial DNA copy number having an important impact on cardio-metabolic risk factors in European origin women.
C1 [Guyatt, Anna L.; Burrows, Kimberley; Ring, Sue; McArdle, Wendy; Lawlor, Debbie A.; Gaunt, Tom R.; Rodriguez, Santiago] Univ Bristol, MRC Integrat Epidemiol Unit, Oakfield House, Bristol BS8 2BN, Avon, England.
   [Guyatt, Anna L.; Burrows, Kimberley; Guthrie, Philip A. I.; Ring, Sue; McArdle, Wendy; Day, Ian N. M.; Lawlor, Debbie A.; Gaunt, Tom R.; Rodriguez, Santiago] Univ Bristol, Sch Social & Community Med, Oakfield House, Bristol BS8 2BN, Avon, England.
   [Ascione, Raimondo] Univ Bristol, Sch Clin Sci, Bristol Heart Inst, Bristol, Avon, England.
C3 University of Bristol; University of Bristol; University of Bristol
RP Rodriguez, S (corresponding author), Univ Bristol, Sch Social & Community Med, Oakfield House, Bristol BS8 2BN, Avon, England.
EM santi.rodriguez@bristol.ac.uk
RI McArdle, Wendy/AGM-4831-2022; Gaunt, Tom/O-3918-2014
OI Guyatt, Anna/0000-0003-1860-6337; Gaunt, Tom/0000-0003-0924-3247;
   Lawlor, Debbie A/0000-0002-6793-2262; Burrows,
   Kimberley/0000-0002-3208-0389; Rodriguez, Santiago/0000-0001-6551-932X
FU UK Medical Research Council; Wellcome Trust [102215/2/13/2]; British
   Heart Foundation [PG/13/66/30442]; Medical Research Council (MRC)
   [MR/K002767/1]; Wellcome Trust PhD studentship [102433/Z/13/Z]; Wellcome
   Trust [102433/Z/13/Z] Funding Source: Wellcome Trust; MRC
   [MC_UU_12013/8, MC_UU_12013/5, MR/K002767/1, MC_UU_00011/4] Funding
   Source: UKRI
FX We are extremely grateful to all the families who took part in ALSPAC,
   the midwives for their help in recruiting them, and the whole ALSPAC
   team, which includes interviewers, computer and laboratory technicians,
   clerical workers, research scientists, volunteers, managers,
   receptionists and nurses. The UK Medical Research Council and the
   Wellcome Trust (Grant ref.: 102215/2/13/2) and the University of Bristol
   provide core support for ALSPAC. We are equally grateful to BWHHS
   participants and for the support and advice of the staff who manage the
   study, and for the hard work of those responsible for recruitment, data
   collection and curation. The British Women's Heart and Health Study is
   supported by the British Heart Foundation (PG/13/66/30442). This
   research was specifically funded by a Medical Research Council (MRC)
   grant awarded to SR (MR/K002767/1). AG is funded by a Wellcome Trust PhD
   studentship (102433/Z/13/Z). Work was carried out in the MRC Integrative
   Epidemiology Unit at the University of Bristol (MC_UU_12013/8).
CR [Anonymous], MITOCHONDRIAL DIS CL
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NR 81
TC 14
Z9 17
U1 0
U2 8
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1567-7249
EI 1872-8278
J9 MITOCHONDRION
JI Mitochondrion
PD MAR
PY 2018
VL 39
BP 9
EP 19
DI 10.1016/j.mito.2017.08.007
PG 11
WC Cell Biology; Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Genetics & Heredity
GA FY0YL
UT WOS:000426538500002
PM 28818596
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Carvalho, F
   Lahlou, RA
   Silva, LR
AF Carvalho, Filomena
   Lahlou, Radhia Aitfella
   Silva, Luis R.
TI Phenolic Compounds from Cherries and Berries for Chronic Disease
   Management and Cardiovascular Risk Reduction
SO NUTRIENTS
LA English
DT Review
DE cherries; berries; red fruits; phenolic compounds; cardiovascular
   diseases
ID HIGH-FAT DIET; DRIED STRAWBERRY POWDER; CORONARY-HEART-DISEASE;
   NITRIC-OXIDE SYNTHASE; OXIDATIVE STRESS; DOUBLE-BLIND; METABOLIC
   SYNDROME; BLOOD-PRESSURE; PRUNUS-CERASUS; GALLIC ACID
AB Cardiovascular diseases (CVDs) are a leading cause of mortality worldwide. Therefore, there is increasing interest in dietary interventions to reduce risk factors associated with these conditions. Cherries and berries are rich sources of bioactive compounds and have attracted attention for their potential cardiovascular benefits. This review summarises the current research on the effects of cherry and berry consumption on cardiovascular health, including in vivo studies and clinical trials. These red fruits are rich in phenolic compounds, such as anthocyanins and flavonoids, which have multiple bioactive properties. These properties include antioxidant, anti-inflammatory, and vasodilatory effects. Studies suggest that regular consumption of these fruits may reduce inflammation and oxidative stress, leading to lower blood pressure, improved lipid profiles, and enhanced endothelial function. However, interpreting findings and establishing optimal dosages is a challenge due to the variability in fruit composition, processing methods, and study design. Despite these limitations, the evidence highlights the potential of cherries and berries as components of preventive strategies against CVD. Further research is needed to maximise their health benefits and improve clinical practice.
C1 [Carvalho, Filomena; Lahlou, Radhia Aitfella; Silva, Luis R.] Inst Politecn Guarda, SPRINT Sport Phys Act & Hlth Res & Innovat Ctr, P-6300559 Guarda, Portugal.
   [Silva, Luis R.] Univ Beira Interior, CICS UBI Hlth Sci Res Ctr, P-6201506 Covilha, Portugal.
   [Silva, Luis R.] Univ Coimbra, Dept Chem Engn, CERES, P-3030790 Coimbra, Portugal.
C3 Instituto Politecnico da Guarda; Universidade da Beira Interior;
   Universidade de Coimbra
RP Silva, LR (corresponding author), Inst Politecn Guarda, SPRINT Sport Phys Act & Hlth Res & Innovat Ctr, P-6300559 Guarda, Portugal.; Silva, LR (corresponding author), Univ Beira Interior, CICS UBI Hlth Sci Res Ctr, P-6201506 Covilha, Portugal.; Silva, LR (corresponding author), Univ Coimbra, Dept Chem Engn, CERES, P-3030790 Coimbra, Portugal.
EM filomenacarvalho@ipg.pt; radhialahlou@ipg.pt; luissilva@ipg.pt
RI Lahlou, RADHIA/AAD-5914-2021; Silva, Luis Rodrigues da/D-5485-2013
OI Aitfella Lahlou, Radhia/0000-0002-6911-6947; Silva, Luis Rodrigues
   da/0000-0001-5264-3516; Carvalho, Filomena/0000-0002-0446-9020
FU CICS-UBI
FX No Statement Available
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NR 153
TC 7
Z9 7
U1 7
U2 12
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JUN
PY 2024
VL 16
IS 11
AR 1597
DI 10.3390/nu16111597
PG 28
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA WA6C2
UT WOS:001252176800001
PM 38892529
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU López-Fernández-Sobrino, R
   Torres-Fuentes, C
   Bravo, FI
   Muguerza, B
AF Lopez-Fernandez-Sobrino, Raul
   Torres-Fuentes, Cristina
   Isabel Bravo, Francisca
   Muguerza, Begona
TI Winery by-products as a valuable source for natural antihypertensive
   agents
SO CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
LA English
DT Review
DE Antioxidant activity; blood pressure; grape; hypertension; phenolic
   compound; wine
ID GRAPE SEED EXTRACT; CARDIOVASCULAR-DISEASE RISK; DECREASE
   BLOOD-PRESSURE; NITRIC-OXIDE; OXIDATIVE STRESS; METABOLIC SYNDROME;
   PROANTHOCYANIDIN EXTRACT; INDUCED HYPERTENSION; SKIN EXTRACT;
   DOUBLE-BLIND
AB Hypertension (HTN) is one of the leading causes of death in the world. Agri-food by-products are emerging as a novel source of natural antihypertensive agents allowing for their valorization and making food and agricultural industries more environmentally friendly. In this regard, wine making process generates large amounts of by-products rich in phenolic compounds that have shown potential to exert several beneficial effects including antihypertensive properties. The aim of this study was to review the blood pressure-lowering effects of winery by-products. In addition, molecular mechanisms involved in their bioactivity were also evaluated. Among the winery by-products, grape seed extracts have widely shown antihypertensive properties in both animal and human studies. Moreover, recent evidence suggests that grape stem, skin and pomace and wine lees may also have great potential to manage HTN, although more studies are needed in order to confirm their potential in humans. Improvement of endothelial dysfunction and reduction of oxidative stress associated with HTN are the main mechanisms involved in the blood pressure-lowering effects of these by-products.
C1 [Lopez-Fernandez-Sobrino, Raul; Torres-Fuentes, Cristina; Isabel Bravo, Francisca; Muguerza, Begona] Univ Rovira & Virgili, Dept Bioquim & Biotecnol, Nutrigen Res Grp, Tarragona, Spain.
C3 Universitat Rovira i Virgili
RP Bravo, FI (corresponding author), Univ Rovira & Virgili, Dept Bioquim & Biotecnol, Nutrigen Res Grp, Tarragona, Spain.
EM franciscaisabel.bravo@urv.cat
RI Torres-Fuentes, Cristina/J-5551-2019; Bravo, Francisca/L-4409-2019;
   Muguerza, Begoña/AAT-3544-2021; Muguerza, Begona/C-6704-2015
OI Muguerza, Begona/0000-0001-7384-8588; Lopez Fernandez,
   Raul/0000-0002-2418-2123; TORRES-FUENTES, CRISTINA/0000-0002-2917-6910;
   Bravo, Francisca Isabel/0000-0002-6468-3088
FU Ministerio de Economia y Competitividad [RETOS COLABORACION:
   RTC-2017-6044-2]; European Regional Development Fund (FEDER)
FX This work has been supported by the grant number RETOS COLABORACION:
   RTC-2017-6044-2 from Ministerio de Economia y Competitividad and
   European Regional Development Fund (FEDER).
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NR 113
TC 10
Z9 10
U1 3
U2 19
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1040-8398
EI 1549-7852
J9 CRIT REV FOOD SCI
JI Crit. Rev. Food Sci. Nutr.
PD OCT 3
PY 2023
VL 63
IS 25
BP 7708
EP 7721
DI 10.1080/10408398.2022.2049202
EA MAR 2022
PG 14
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA T2ZD1
UT WOS:000767654000001
PM 35275757
DA 2025-06-11
ER

PT J
AU Kuan, PF
   Yang, XH
   Ren, X
   Che, C
   Waszczuk, M
   Kotov, R
   Clouston, S
   Singh, PK
   Glenn, ST
   Gomez, EC
   Wang, JM
   Bromet, E
   Luft, BJ
AF Kuan, Pei-Fen
   Yang, Xiaohua
   Ren, Xu
   Che, Chang
   Waszczuk, Monika
   Kotov, Roman
   Clouston, Sean
   Singh, Prashant K.
   Glenn, Sean T.
   Gomez, Eduardo Cortes
   Wang, Jianmin
   Bromet, Evelyn
   Luft, Benjamin J.
TI Mapping the transcriptomics landscape of post-traumatic stress disorder
   symptom dimensions in World Trade Center responders
SO TRANSLATIONAL PSYCHIATRY
LA English
DT Article
ID FALSE DISCOVERY RATE; GENE-EXPRESSION; NEUROTROPHIC FACTOR; METABOLIC
   SYNDROME; DEPLOYED MARINES; PTSD SYMPTOMS; RISK; ASSOCIATION;
   COMORBIDITY; PREVALENCE
AB Gene expression has provided promising insights into the pathophysiology of post-traumatic stress disorder (PTSD); however, specific regulatory transcriptomic mechanisms remain unknown. The present study addressed this limitation by performing transcriptome-wide RNA-Seq of whole-blood samples from 226 World Trade Center responders. The investigation focused on differential expression (DE) at the gene, isoform, and for the first time, alternative splicing (AS) levels associated with the symptoms of PTSD: total burden, re-experiencing, avoidance, numbing, and hyperarousal subdimensions. These symptoms were associated with 76, 1, 48, 15, and 49 DE genes, respectively (FDR<0.05). Moreover, they were associated with 103, 11, 0, 43, and 32 AS events. Avoidance differed the most from other dimensions with respect to DE genes and AS events. Gene set enrichment analysis (GSEA) identified pathways involved in inflammatory and metabolic processes, which may have implications in the treatment of PTSD. Overall, the findings shed a novel light on the wide range of transcriptomic alterations associated with PTSD at the gene and AS levels. The results of DE analysis associated with PTSD subdimensions highlights the importance of studying PTSD symptom heterogeneity.
C1 [Kuan, Pei-Fen; Ren, Xu; Che, Chang] SUNY Stony Brook, Dept Appl Math & Stat, Stony Brook, NY 11794 USA.
   [Yang, Xiaohua; Luft, Benjamin J.] SUNY Stony Brook, Dept Med, Stony Brook, NY 11794 USA.
   [Waszczuk, Monika] Rosalind Franklin Univ Med & Sci, Dept Psychol, N Chicago, IL USA.
   [Kotov, Roman; Bromet, Evelyn] SUNY Stony Brook, Dept Psychiat, Stony Brook, NY 11794 USA.
   [Clouston, Sean] SUNY Stony Brook, Dept Family & Prevent Med, Stony Brook, NY 11794 USA.
   [Singh, Prashant K.; Glenn, Sean T.] Roswell Park Canc Inst, Dept Canc Genet, Buffalo, NY USA.
   [Gomez, Eduardo Cortes; Wang, Jianmin] Roswell Park Canc Inst, Dept Biostat & Bioinformat, Buffalo, NY USA.
C3 State University of New York (SUNY) System; Stony Brook University;
   State University of New York (SUNY) System; Stony Brook University;
   Rosalind Franklin University of Medicine & Science; State University of
   New York (SUNY) System; Stony Brook University; State University of New
   York (SUNY) System; Stony Brook University; Roswell Park Comprehensive
   Cancer Center; Roswell Park Comprehensive Cancer Center
RP Kuan, PF (corresponding author), SUNY Stony Brook, Dept Appl Math & Stat, Stony Brook, NY 11794 USA.; Luft, BJ (corresponding author), SUNY Stony Brook, Dept Med, Stony Brook, NY 11794 USA.
EM peifen.kuan@stonybrook.edu; Benjamin.luft@stonybrookmediine.edu
RI Kotov, Roman/KZV-1103-2024; SINGH, PRASHANT/K-5405-2014; Yang,
   Xiaohua/H-5053-2011; Andrade, Laura Helena/F-3023-2010; Cortes,
   Eduardo/AAW-8005-2021; Waszczuk, Monika/AAP-7716-2020; Kuan, Pei
   Fen/GRX-4622-2022; Clouston, Sean/L-4653-2013
OI Clouston, Sean/0000-0002-6124-0329
FU CDC/NIOSH award [U01 OH011478]; National Cancer Institute (NCI)
   [P30CA016056]
FX The present study was supported in part by the CDC/NIOSH award U01
   OH011478 (PI: Pei Fen Kuan). We gratefully acknowledge the support of
   the first responders and rescue/recovery workers for participating in
   this study. We also thank the staff of the Stony Brook World Trade
   Center Health Program and the World Trade Center Health Program Data
   Monitoring Center for ongoing support. The findings and conclusions
   presented in this article are those of the authors and do not represent
   the official position of NIOSH, the CDC, or the U.S. Public Health
   Service. This work was partly supported by National Cancer Institute
   (NCI) grant P30CA016056 involving the use of Roswell Park Comprehensive
   Cancer Center's Genomic and Bioinformatics Shared Resources.
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NR 70
TC 4
Z9 5
U1 1
U2 6
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 2158-3188
J9 TRANSL PSYCHIAT
JI Transl. Psychiatr.
PD MAY 24
PY 2021
VL 11
IS 1
AR 310
DI 10.1038/s41398-021-01431-6
PG 9
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA SN8CT
UT WOS:000658515100001
PM 34031375
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Ballard, KD
   Bruno, RS
AF Ballard, Kevin D.
   Bruno, Richard S.
TI Protective role of dairy and its constituents on vascular function
   independent of blood pressure-lowering activities
SO NUTRITION REVIEWS
LA English
DT Review
DE cardiovascular disease; dairy; low-fat dairy; nitric oxide; vascular
   function; whey protein
ID FLOW-MEDIATED DILATION; INCIDENT CARDIOVASCULAR-DISEASE; DOSE-RESPONSE
   METAANALYSIS; SMALL ARTERY ELASTICITY; WHEY-PROTEIN ISOLATE; C-REACTIVE
   PROTEIN; ENDOTHELIAL FUNCTION; METABOLIC SYNDROME; OXIDATIVE STRESS;
   INFLAMMATORY MARKERS
AB Greater intakes of dairy are frequently associated with reduced risk of cardiovascular disease. These observational studies have served as the basis for controlled interventions aimed at defining the cardioprotective mechanisms of dairy. Understanding these relationships is of public health importance because most of the US population fails to meet dietary recommendations for dairy, suggesting that many individuals could lower their cardiovascular disease risk by relatively simple dietary modification. Clinical studies investigating the acute ingestion of dairy or its constituents, including short-term (<= 2 week) supplementation studies or those assessing postprandial responses, have largely shown benefits on vascular function without concomitant improvements in blood pressure. Chronic interventions have been less conclusive, with some showing benefits and others indicating a lack of improvement in vascular function regardless of blood pressure changes. Vasoprotective activities of dairy are likely mediated through improvements in nitric oxide bioavailability, oxidative stress, inflammation, and insulin resistance. Future controlled studies are needed to determine if these health benefits are mediated directly by dairy or indirectly by displacing other dietary components that otherwise impair vascular health.
C1 [Ballard, Kevin D.] Hartford Hosp, Div Cardiol, Henry Low Heart Ctr, Hartford, CT 06115 USA.
   [Bruno, Richard S.] Ohio State Univ, Dept Human Sci, Human Nutr Program, Columbus, OH 43210 USA.
C3 Hartford Hospital; University System of Ohio; Ohio State University
RP Bruno, RS (corresponding author), Ohio State Univ, Dept Human Sci, Human Nutr Program, 325 Campbell Hall,1787 Neil Ave, Columbus, OH 43210 USA.
EM Bruno.27@osu.edu
RI Bruno, Richard/K-1930-2012
OI Bruno, Richard/0000-0002-6772-2038; Ballard, Kevin/0000-0001-7587-1220
FU Dairy Research Institute (Rosemont, IL, USA)
FX This work was supported, in part, by grants to R.S.B. from the Dairy
   Research Institute (Rosemont, IL, USA). The Dairy Research Institute did
   not have final approval for the content of this article.
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NR 141
TC 18
Z9 18
U1 0
U2 17
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0029-6643
EI 1753-4887
J9 NUTR REV
JI Nutr. Rev.
PD JAN
PY 2015
VL 73
IS 1
BP 36
EP 50
DI 10.1093/nutrit/nuu013
PG 15
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA AY0NE
UT WOS:000347292200005
PM 26024056
OA Bronze
DA 2025-06-11
ER

PT J
AU Lee, SM
   Cho, YH
   Lee, SY
   Jeong, DW
   Cho, AR
   Jeon, JS
   Park, EJ
   Kim, YJ
   Lee, JG
   Yi, YH
   Tak, YJ
   Hwang, HR
   Lee, SH
   Han, J
AF Lee, Sun Min
   Cho, Young Hye
   Lee, Sang Yeoup
   Jeong, Dong Wook
   Cho, A. Ra
   Jeon, Jeong Suk
   Park, Eun-Ju
   Kim, Yun Jin
   Lee, Jeong Gyu
   Yi, Yu Hyeon
   Tak, Young Jin
   Hwang, Hye Rim
   Lee, Seung-Hun
   Han, Junehee
TI Urinary Malondialdehyde Is Associated with Visceral Abdominal Obesity in
   Middle-Aged Men
SO MEDIATORS OF INFLAMMATION
LA English
DT Article
ID C-REACTIVE PROTEIN; BODY-MASS INDEX; OXIDATIVE STRESS;
   LIPID-PEROXIDATION; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   INFLAMMATION; RISK; ACID; SMOKING
AB The purpose of the present study was to investigate multiple anthropometric parameters used to evaluate obesity, particularly visceral abdominal fat area, and various metabolic parameters includingmalondialdehyde (MDA) as an oxidative stress marker. We evaluated various measures of obesity, including body mass index (BMI), waist circumference (WC), sagittal abdominal diameter, fat percentages using dual-energy X-ray absorptiometry, visceral fat area (VFA), subcutaneous fat area, multiple biomarkers related to metabolic disease, and urinary MDA, in 73 asymptomatic middle-aged men who were not severely obese. We examined relationships between multiple measures of obesity, metabolic markers, and urinary MDA levels and evaluated associations between VFA and urinary MDA. In the visceral obesity group, gamma-glutamyl transferase (GGT), uric acid, and urinary MDA levels were significantly higher than in the nonvisceral obesity group (P = 0.008, P = 0.002, and P = 0.018). Urinary MDA (r = 0.357, P = 0.002) and uric acid (r = 0.263, P = 0.027) levels were only significantly positively correlated with VFA among measures of obesity. Urinary MDA, serum GGT, and serum CRP were significantly positively associated with VFA (P = 0.001, P = 0.046, and P = 0.023, resp.), even after adjusting for BMI and WC.
C1 [Lee, Sun Min] Pusan Natl Univ, Yangsan Hosp, Dept Lab Med & Mol Genet, Yangsan 626770, South Korea.
   [Lee, Sun Min; Cho, Young Hye; Lee, Sang Yeoup; Jeong, Dong Wook; Cho, A. Ra; Jeon, Jeong Suk; Park, Eun-Ju] Pusan Natl Univ, Yangsan Hosp, Res Inst Convergence Biomed Sci & Technol, Yangsan 626770, South Korea.
   [Cho, Young Hye; Lee, Sang Yeoup; Jeong, Dong Wook; Cho, A. Ra; Jeon, Jeong Suk; Park, Eun-Ju] Pusan Natl Univ, Yangsan Hosp, Family Med Clin, Yangsan 626770, South Korea.
   [Kim, Yun Jin; Lee, Jeong Gyu; Yi, Yu Hyeon; Tak, Young Jin; Hwang, Hye Rim; Lee, Seung-Hun] Pusan Natl Univ Hosp, Dept Family Med, Busan 49241, South Korea.
   [Han, Junehee] Pusan Natl Univ, Yangsan Hosp, Res & Stat Support, Res Inst Convergence Biomed Sci & Technol, Yangsan 626770, South Korea.
C3 Pusan National University; Pusan National University Hospital; Pusan
   National University; Pusan National University Hospital; Pusan National
   University; Pusan National University Hospital; Pusan National
   University; Pusan National University Hospital; Pusan National
   University; Pusan National University Hospital
RP Cho, YH (corresponding author), Pusan Natl Univ, Yangsan Hosp, Family Med Clin, Yangsan 626770, South Korea.
EM younghye82@naver.com
RI Cho, Young Hye/AEJ-4099-2022; Lee, Sang Yeoup/IZE-0083-2023; Park,
   Eunju/AAC-5266-2021; LEE, SUN HEE/AAB-5714-2022; Lee, Sun
   Min/R-7717-2019
OI Cho, Young-Hye/0000-0003-2176-6227; Lee, Sang Yeoup/0000-0002-3585-9910;
   Lee, Jeong Gyu/0000-0001-7160-0714
FU DFI Co., Ltd.
FX This study was supported by a grant from DFI Co., Ltd.
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NR 33
TC 9
Z9 10
U1 0
U2 3
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 0962-9351
EI 1466-1861
J9 MEDIAT INFLAMM
JI Mediat. Inflamm.
PY 2015
VL 2015
AR 524291
DI 10.1155/2015/524291
PG 6
WC Cell Biology; Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Immunology
GA CU5YU
UT WOS:000363608800001
PM 26538829
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Guarnieri, G
   Zanetti, M
   Vinci, P
   Cattin, MR
   Barazzoni, R
AF Guarnieri, Gianfranco
   Zanetti, Michela
   Vinci, Pierandrea
   Cattin, Maria Rosa
   Barazzoni, Rocco
TI Insulin Resistance in Chronic Uremia
SO JOURNAL OF RENAL NUTRITION
LA English
DT Article
CT 14th International Congress on Nutrition and Metabolism in Renal Disease
CY JUN 11-15, 2008
CL Marseille, FRANCE
ID CHRONIC KIDNEY-DISEASE; STAGE RENAL-DISEASE; MUSCLE PROTEIN-DEGRADATION;
   BODY-MASS INDEX; OXIDATIVE STRESS; HEMODIALYSIS-PATIENTS;
   SKELETAL-MUSCLE; METABOLIC SYNDROME; FAT MASS; LIPID-METABOLISM
AB Insulin resistance often characterizes chronic uremia, and is associated with enhanced morbidity and mortality, because it may contribute to protein-energy wasting (in turn, an independent predictor of reduced survival), atherosclerosis, and cardiovascular death. Causes of insulin resistance in chronic uremia are complex and multifactorial. Obesity is emerging as an independent risk factor for chronic kidney disease, and an expected rise in number of obese uremic patients because of the ongoing worldwide obesity epidemic is likely to increase the prevalence of insulin resistance in chronic uremia in the near future. Similar to the general population, reported associations between obesity and insulin resistance in chronic uremia support a role of adipose tissue and altered adipokine profiles in insulin resistance in obese chronic kidney disease patients. Hormonal imbalances, chronic acidosis, and systemic inflammation and oxidative stress are uremia-associated relevant causes of insulin resistance in nonobese individuals. A further understanding of the causes of insulin resistance in chronic uremia represents a potential important tool in the design of more effective therapeutic strategies to reduce uremia-associated morbidity and mortality. (C) 2009 by the National Kidney Foundation, Inc. All rights reserved.
C1 [Guarnieri, Gianfranco; Zanetti, Michela; Vinci, Pierandrea; Cattin, Maria Rosa; Barazzoni, Rocco] Univ Trieste, Dept Clin Morphol & Technol Sci, Med Clin, Trieste, Italy.
C3 University of Trieste
RP Guarnieri, G (corresponding author), Osped Cattinara, Med Clin, Str Fiume 447, I-34100 Trieste, Italy.
EM guarnier@units.it
RI Guarnieri, Giovanni/ABE-8112-2020
OI ZANETTI, MICHELA/0000-0002-2634-6363
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NR 46
TC 35
Z9 38
U1 0
U2 2
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 1051-2276
J9 J RENAL NUTR
JI J. Renal Nutr.
PD JAN
PY 2009
VL 19
IS 1
BP 20
EP 24
DI 10.1053/j.jrn.2008.11.014
PG 5
WC Nutrition & Dietetics; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics; Urology & Nephrology
GA 400HH
UT WOS:000262858100005
PM 19121765
DA 2025-06-11
ER

PT J
AU Jimenez-Blasco, D
   Agulla, J
   Lapresa, R
   Garcia-Macia, M
   Bobo-Jimenez, V
   Garcia-Rodriguez, D
   Manjarres-Raza, I
   Fernandez, E
   Jeanson, Y
   Khoury, S
   Portais, JC
   Padro, D
   Ramos-Cabrer, P
   Carmeliet, P
   Almeida, A
   Bolanos, JP
AF Jimenez-Blasco, Daniel
   Agulla, Jesus
   Lapresa, Rebeca
   Garcia-Macia, Marina
   Bobo-Jimenez, Veronica
   Garcia-Rodriguez, Dario
   Manjarres-Raza, Israel
   Fernandez, Emilio
   Jeanson, Yannick
   Khoury, Spiro
   Portais, Jean-Charles
   Padro, Daniel
   Ramos-Cabrer, Pedro
   Carmeliet, Peter
   Almeida, Angeles
   Bolanos, Juan P.
TI Weak neuronal glycolysis sustains cognition and organismal fitness
SO NATURE METABOLISM
LA English
DT Article
ID PENTOSE-PHOSPHATE PATHWAY; BRAIN; LACTATE; INTEGRATION; DEFICIENCY;
   METABOLISM; SHUTTLE; KINASE; ENERGY; MODEL
AB The energy cost of neuronal activity is mainly sustained by glucose 1,2 . However, in an apparent paradox, neurons modestly metabolize glucose through glycolysis 3-6 , a circumstance that can be accounted for by the constant degradation of 6-phosphofructo-2-kinase-fructose-2,6-bisphosphatase-3 (PFKFB3) 3,7,8 , a key glycolysis-promoting enzyme. To evaluate the in vivo physiological importance of this hypoglycolytic metabolism, here we genetically engineered mice with their neurons transformed into active glycolytic cells through Pfkfb3 expression. In vivo molecular, biochemical and metabolic flux analyses of these neurons revealed an accumulation of anomalous mitochondria, complex I disassembly, bioenergetic deficiency and mitochondrial redox stress. Notably, glycolysis-mediated nicotinamide adenine dinucleotide (NAD+) reduction impaired sirtuin-dependent autophagy. Furthermore, these mice displayed cognitive decline and a metabolic syndrome that was mimicked by confining Pfkfb3 expression to hypothalamic neurons. Neuron-specific genetic ablation of mitochondrial redox stress or brain NAD+ restoration corrected these behavioural alterations. Thus, the weak glycolytic nature of neurons is required to sustain higher-order organismal functions.
   Jim & eacute;nez-Blasco et al. show that neurons exhibit moderately low glycolytic rates despite their activity being mainly supported by glucose to preserve redox balance.
C1 [Jimenez-Blasco, Daniel; Agulla, Jesus; Lapresa, Rebeca; Garcia-Macia, Marina; Bobo-Jimenez, Veronica; Garcia-Rodriguez, Dario; Manjarres-Raza, Israel; Fernandez, Emilio; Almeida, Angeles; Bolanos, Juan P.] Univ Salamanca, Inst Funct Biol & Genom, CSIC, Salamanca, Spain.
   [Jimenez-Blasco, Daniel; Agulla, Jesus; Lapresa, Rebeca; Garcia-Macia, Marina; Bobo-Jimenez, Veronica; Garcia-Rodriguez, Dario; Manjarres-Raza, Israel; Fernandez, Emilio; Almeida, Angeles; Bolanos, Juan P.] Univ Salamanca, Hosp Univ Salamanca, Inst Biomed Res Salamanca IBSAL, CSIC, Salamanca, Spain.
   [Jimenez-Blasco, Daniel; Garcia-Macia, Marina; Garcia-Rodriguez, Dario; Manjarres-Raza, Israel; Fernandez, Emilio; Bolanos, Juan P.] Ctr Invest Biomed Red Fragil & Envejecimiento Salu, Madrid, Spain.
   [Jeanson, Yannick; Khoury, Spiro; Portais, Jean-Charles] Univ Toulouse, Inserm U1031, CNRS 5070, UPS,EFS,RESTORE, Toulouse, France.
   [Khoury, Spiro; Portais, Jean-Charles] Natl Infrastruct Metabol & Flux, MetaboHUB MetaToul, Toulouse, France.
   [Portais, Jean-Charles] Toulouse Biotechnol Inst, INSA Toulouse INSA CNRS 5504, UMR INSA INRA 792, Toulouse, France.
   [Padro, Daniel; Ramos-Cabrer, Pedro] Basque Res & Technol Alliance, CIC biomaGUNE, Donostia San Sebastian, Spain.
   [Ramos-Cabrer, Pedro] Basque Fdn Sci, Ikerbasque, Bilbao, Spain.
   [Carmeliet, Peter] Katholieke Univ Leuven, Dept Oncol, Ctr Canc Biol, Lab Angiogenesis & Vasc Metab, Leuven, Belgium.
   [Carmeliet, Peter] Katholieke Univ Leuven, Leuven Canc Inst LKI VIB VIB, Ctr Canc Biol, Leuven, Belgium.
   [Carmeliet, Peter] Khalifa Univ Sci & Technol, Ctr Biotechnol, Abu Dhabi, U Arab Emirates.
C3 University of Salamanca; Consejo Superior de Investigaciones Cientificas
   (CSIC); University of Salamanca; Consejo Superior de Investigaciones
   Cientificas (CSIC); Institut National de la Sante et de la Recherche
   Medicale (Inserm); Universite de Toulouse; Universite Toulouse III -
   Paul Sabatier; INRAE; Universite de Toulouse; Universite Federale
   Toulouse Midi-Pyrenees (ComUE); Institut National des Sciences
   Appliquees de Toulouse; Centre National de la Recherche Scientifique
   (CNRS); CIC biomaGUNE; Basque Foundation for Science; KU Leuven; KU
   Leuven; Khalifa University of Science & Technology
RP Bolanos, JP (corresponding author), Univ Salamanca, Inst Funct Biol & Genom, CSIC, Salamanca, Spain.; Bolanos, JP (corresponding author), Univ Salamanca, Hosp Univ Salamanca, Inst Biomed Res Salamanca IBSAL, CSIC, Salamanca, Spain.; Bolanos, JP (corresponding author), Ctr Invest Biomed Red Fragil & Envejecimiento Salu, Madrid, Spain.
EM jbolanos@usal.es
RI ALMEIDA, ANGELES/B-4727-2017; Lapresa, Rebeca/E-2337-2018; Bolaños,
   Juan/M-9518-2019; Padro, Daniel/AAG-3529-2021; Jiménez,
   Verónica/AAD-5991-2021; KHOURY, Spiro/AAQ-7657-2021; Garcia Macia,
   Marina/AAY-4728-2021; Ramos-Cabrer, Pedro/AAF-1467-2020; Carmeliet,
   Peter/AAQ-5140-2020; García Rodríguez, Darío/GNO-9524-2022; Manjarrés
   Raza, Darwin/AFY-1189-2022; Padro, Daniel/L-4091-2015; Ramos-Cabrer,
   Pedro/J-5306-2014; JIMENEZ, DANIEL/F-4666-2016; Agulla Freire,
   Jesus/E-2326-2018; Garcia-Macia, Marina/G-6622-2015
OI Garcia-Rodriguez, Dario/0000-0001-5416-130X; Padro,
   Daniel/0000-0002-3932-9351; Carmeliet, Peter/0000-0001-7961-1821;
   Ramos-Cabrer, Pedro/0000-0003-0368-7031; JIMENEZ,
   DANIEL/0000-0002-1384-1832; Jeanson, Yannick/0000-0001-5325-3130; Bobo
   Jimenez, Veronica/0000-0003-4111-631X; Manjarres Raza, Darwin
   Israel/0000-0001-6314-9839; Agulla Freire, Jesus/0000-0001-9574-2549;
   Garcia-Macia, Marina/0000-0002-3908-9060; KHOURY,
   Spiro/0000-0003-0365-7406; Lapresa, Rebeca/0000-0001-8901-3972
FU Fondo Social Europeo; Youth Employment Initiative; Junta de Castilla y
   Leon [101072759, PID2019-105699RB-I00]; MICIU/AEI
   [PID2022-138813OB-I00]; FEDER, UE; La Caixa Foundation [PI21/00727];
   Instituto de Salud Carlos III [RD16/0019/0018, PMP22/00084, CSI011P23,
   CLU-2017-03]; European Union [ANR-11-INBS-0010]; French National
   Research Agency (ANR);  [LCF/PR/HR23/52430016];  [CB16/10/00282]; Marie
   Curie Actions (MSCA) [101072759] Funding Source: Marie Curie Actions
   (MSCA)
FX We acknowledge the technical assistance of M. Resch, M.
   Carabias-Carrasco, L. Martin and E. Prieto-Garcia from the University of
   Salamanca. E. Prieto-Garcia was a recipient of a position by the Fondo
   Social Europeo, Youth Employment Initiative, Junta de Castilla y Leon.
   Staff members (A. Rocher, H. Kulyk, N. Lager-Lachaud, L. Gales, F.
   Bellvert) of MetaToul (Toulouse, France, https://metatoul.fr) are
   gratefully acknowledged for technical support and access to MS
   facilities. The projects that gave rise to these results were funded by
   MICIU/AEI (PID2022-138813OB-I00,
   PID2019-105699RB-I00/10.13039/501100011033 and FEDER, UE to J.P.B.;
   SAF2017-90794-REDT to A.A.), la Caixa Foundation (grant agreement
   LCF/PR/HR23/52430016 to J.P.B.), the Instituto de Salud Carlos III
   (CB16/10/00282 to J.P.B.; PI21/00727, RD16/0019/0018, PMP22/00084 to
   A.A.), the Junta de Castilla y Leon (CSI011P23 and Escalera de
   Excelencia CLU-2017-03 to J.P.B. and A.A.) and the European Union's
   Horizon Europe research and innovation programme under MSCA Doctoral
   Networks 2021 (101072759, FuEl ThE bRaiN In healtThY aging and
   age-related diseases (ETERNITY), to J.P.B. and A.A.). MetaToul is part
   of the national infrastructure MetaboHUB and is funded by the French
   National Research Agency (ANR) with grant number
   MetaboHUB-ANR-11-INBS-0010.
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NR 61
TC 11
Z9 12
U1 5
U2 16
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
EI 2522-5812
J9 NAT METAB
JI Nat. Metab.
PD JUL
PY 2024
VL 6
IS 7
DI 10.1038/s42255-024-01049-0
EA MAY 2024
PG 30
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA ZV2U5
UT WOS:001235774400002
PM 38789798
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Yang, YT
   Zhang, PZ
   Zhu, XL
AF Yang, Yuting
   Zhang, Peizhen
   Zhu, Xiaolan
TI Effects of crossover point exercise and high-intensity interval training
   on vascular health in young overweight females
SO APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
LA English
DT Article
DE crossover point exercise; high-intensity interval training; vascular
   health; cardiovascular risk; overweight women; exercise
ID BLOOD-PRESSURE; ARTERIAL STIFFNESS; METABOLIC SYNDROME; OXIDATIVE
   STRESS; HYPERTENSION; HOMOCYSTEINE; MANAGEMENT; ADULTS; WOMEN;
   INFLAMMATION
AB This study investigated the effects of 10 weeks of crossover point (COP) exercise training and high-intensity interval training (HIIT) on cardiovascular risk factors and vascular health in overweight young women. Overweight young women were randomized into HIIT and COP groups. Participants in the HIIT group (n = 10; age = 22 +/- 2, body mass index (BMI) = 25.72 +/- 0.90) and COP group (n = 10, age = 21 +/- 2, BMI = 25.90 +/- 1.90) took part in 10 weeks of HIIT and COP exercise training, respectively. Cardiorespiratory fitness, cardiovascular health, and oxidative stress indicators were measured before and after the intervention period. After 10 weeks of exercise intervention, both COP exercise and HIIT led to a significant increase in maximal oxygen uptake (p < 0.001). The systolic blood pressure (p = 0.006), diastolic blood pressure (p = 0.006), and brachial-ankle pulse wave velocity (p = 0.002) were significantly decreased in both COP group and HIIT group, while serum interleukin-6 levels were increased in HIIT and COP groups. The present study shows that a training program at COP could be an effective strategy to protect vascular health.
C1 [Yang, Yuting; Zhang, Peizhen] Beijing Sport Univ, Sch Sports Med & Rehabil, Beijing, Peoples R China.
   [Zhu, Xiaolan] Beijing Sport Univ, Sport Sci Coll, Beijing, Peoples R China.
C3 Beijing Sport University; Beijing Sport University
RP Zhang, PZ (corresponding author), Beijing Sport Univ, Sch Sports Med & Rehabil, Beijing, Peoples R China.
EM zhpzh@bsu.edu.cn
RI Zhu, xiaolan/GSM-8306-2022; Yang, Yuting/C-8527-2014
FU National Key R&D Program of China [2022YFC2010201]; Fundamental Research
   Funds for the Central Universities [2020045]; Science and Technology
   Project of China Institute of Sport Science [2017HT016]; Key Laboratory
   of Exercise and Physical Fitness (Beijing Sport University) , Ministry
   of Education
FX This work was supported by the National Key R&D Program of China (Grant
   No. 2022YFC2010201) , Fundamental Research Funds for the Central
   Universities (Grant No. 2020045) , Science and Technology Project of
   China Institute of Sport Science (Grant No. 2017HT016) , and Key
   Laboratory of Exercise and Physical Fitness (Beijing Sport University) ,
   Ministry of Education. The results of the study are presented clearly,
   honestly, and without fabrication, falsification, or inappropriate data
   manipulation. The authors sincerely thank all participants who took part
   in the study.
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NR 54
TC 3
Z9 3
U1 1
U2 11
PU CANADIAN SCIENCE PUBLISHING
PI OTTAWA
PA 123 Slater Street, Suite 610, OTTAWA, ON K1P 5H2, CANADA
SN 1715-5312
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J9 APPL PHYSIOL NUTR ME
JI Appl. Physiol. Nutr. Metab.
PD JAN
PY 2024
VL 49
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BP 77
EP 86
DI 10.1139/apnm-2023-0054
EA OCT 2023
PG 10
WC Nutrition & Dietetics; Physiology; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics; Physiology; Sport Sciences
GA EH2G0
UT WOS:001084270300001
PM 37611320
DA 2025-06-11
ER

PT J
AU Puchalowicz, K
   Rac, ME
AF Puchalowicz, Kamila
   Rac, Monika Ewa
TI The Multifunctionality of CD36 in Diabetes Mellitus and Its
   Complications-Update in Pathogenesis, Treatment and Monitoring
SO CELLS
LA English
DT Review
DE cardiomyopathy; hyperglycemia; fatty acids; inflammation; insulin
   resistance; lipotoxicity; nephropathy; neuropathy; oxidative stress;
   retinopathy
ID FATTY-ACID TRANSPORT; LOW-DENSITY-LIPOPROTEIN; PANCREATIC BETA-CELLS;
   INTRAMYOCELLULAR CERAMIDE ACCUMULATION; HEPATIC INSULIN-RESISTANCE;
   TUBULAR EPITHELIAL-CELLS; SCAVENGER RECEPTOR CD36; SOLUBLE CD36;
   OXIDIZED LDL; LIPID-ACCUMULATION
AB CD36 is a multiligand receptor contributing to glucose and lipid metabolism, immune response, inflammation, thrombosis, and fibrosis. A wide range of tissue expression includes cells sensitive to metabolic abnormalities associated with metabolic syndrome and diabetes mellitus (DM), such as monocytes and macrophages, epithelial cells, adipocytes, hepatocytes, skeletal and cardiac myocytes, pancreatic beta-cells, kidney glomeruli and tubules cells, pericytes and pigment epithelium cells of the retina, and Schwann cells. These features make CD36 an important component of the pathogenesis of DM and its complications, but also a promising target in the treatment of these disorders. The detrimental effects of CD36 signaling are mediated by the uptake of fatty acids and modified lipoproteins, deposition of lipids and their lipotoxicity, alterations in insulin response and the utilization of energy substrates, oxidative stress, inflammation, apoptosis, and fibrosis leading to the progressive, often irreversible organ dysfunction. This review summarizes the extensive knowledge of the contribution of CD36 to DM and its complications, including nephropathy, retinopathy, peripheral neuropathy, and cardiomyopathy.
C1 [Puchalowicz, Kamila; Rac, Monika Ewa] Pomeranian Med Univ, Dept Biochem, PL-70111 Szczecin, Poland.
C3 Pomeranian Medical University
RP Puchalowicz, K (corresponding author), Pomeranian Med Univ, Dept Biochem, PL-70111 Szczecin, Poland.
EM kamila.puchalowicz@pum.edu.pl; carmon12@gmail.com
RI Puchalowicz, Kamila/T-5331-2018; Rac, Monika/A-5292-2015
OI Puchalowicz, Kamila/0000-0001-8109-7112; Rac, Monika/0000-0003-1561-346X
FU Pomeranian Medical University's Science Stimulation Fund Program
   [FSN-130-01/18]
FX This research was funded by a grant from the Pomeranian Medical
   University's Science Stimulation Fund Program (grant number:
   FSN-130-01/18).
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NR 264
TC 41
Z9 45
U1 1
U2 13
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2073-4409
J9 CELLS-BASEL
JI Cells
PD AUG
PY 2020
VL 9
IS 8
AR 1877
DI 10.3390/cells9081877
PG 41
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA NH8CI
UT WOS:000564891300001
PM 32796572
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Flori, L
   Macaluso, M
   Taglieri, I
   Sanmartin, C
   Sgherri, C
   De Leo, M
   Ciccone, V
   Donnini, S
   Venturi, F
   Pistelli, L
   Martelli, A
   Calderone, V
   Testai, L
   Zinnai, A
AF Flori, Lorenzo
   Macaluso, Monica
   Taglieri, Isabella
   Sanmartin, Chiara
   Sgherri, Cristina
   De Leo, Marinella
   Ciccone, Valerio
   Donnini, Sandra
   Venturi, Francesca
   Pistelli, Luisa
   Martelli, Alma
   Calderone, Vincenzo
   Testai, Lara
   Zinnai, Angela
TI Development of Fortified Citrus Olive Oils: From Their Production to
   Their Nutraceutical Properties on the Cardiovascular System
SO NUTRIENTS
LA English
DT Article
DE extra virgin olive oil; cryogen; Citrusgenus; phytochemical;
   nutraceutical value; Citrus x aurantium; Citrus limon; cardiovascular
   protection
ID ANTIOXIDANT ACTIVITY; PHENOLIC-COMPOUNDS; ENDOTHELIAL DYSFUNCTION;
   NARINGENIN; EXTRACTION; HESPERETIN; MODEL; COLOR; MS
AB Recently the use of food by-products as natural sources of biologically active substances has been extensively investigated especially for the development of functional foods fortified with natural antioxidants. Due to their content of bioactive compounds, such as carotenoids, flavonoids and limonoids, citruspeels could be suitable to formulate enriched olive oils able to boost healthy nutrition. The aim of this study was: (i) to determine the compositional and sensory profiles of citrus olive oil; and (ii) to evaluate its nutraceutical properties in rats with high fat diet-induced metabolic syndrome and oxidative stress. The results obtained show the potential of using citrus peels as a source of bioactive compounds to improve the sensory profile as well as the phytochemical composition of olive oil. We demonstrated that the production system ofCitrus x aurantiumolive oil andCitrus limonolive oil improves its organoleptic properties without altering its beneficial effects, which, like control extra virgin olive oil, showed protective effects relating to glucose and serum lipid levels, metabolic activity of adipocytes, myocardial tissue functionality, oxidative stress markers and endothelial function at blood vessel level.
C1 [Flori, Lorenzo; De Leo, Marinella; Pistelli, Luisa; Martelli, Alma; Calderone, Vincenzo; Testai, Lara; Zinnai, Angela] Univ Pisa, Dept Pharm, Via Bonanno Pisano 6, I-56126 Pisa, Italy.
   [Macaluso, Monica; Taglieri, Isabella; Sanmartin, Chiara; Sgherri, Cristina; Venturi, Francesca] Univ Pisa, Dept Agr Food & Environm DAFE, Via Borghetto 80, I-56124 Pisa, Italy.
   [Sanmartin, Chiara; De Leo, Marinella; Venturi, Francesca; Pistelli, Luisa; Martelli, Alma; Calderone, Vincenzo; Testai, Lara; Zinnai, Angela] Univ Pisa, Interdept Res Ctr Nutraceut & Food Hlth, Via Borghetto 80, I-56124 Pisa, Italy.
   [Ciccone, Valerio; Donnini, Sandra] Univ Siena, Dept Life Sci, Via Aldo Moro 2, I-53100 Siena, Italy.
   [Ciccone, Valerio; Donnini, Sandra] Toscana Life Sci, Str Petriccio & Belriguardo 35, I-53100 Siena, Italy.
C3 University of Pisa; University of Pisa; University of Pisa; University
   of Siena
RP Testai, L (corresponding author), Univ Pisa, Dept Pharm, Via Bonanno Pisano 6, I-56126 Pisa, Italy.; Sanmartin, C (corresponding author), Univ Pisa, Dept Agr Food & Environm DAFE, Via Borghetto 80, I-56124 Pisa, Italy.; Sanmartin, C; Testai, L (corresponding author), Univ Pisa, Interdept Res Ctr Nutraceut & Food Hlth, Via Borghetto 80, I-56124 Pisa, Italy.
EM lorenzo.flori@phd.unipi.it; monica.macaluso@phd.unipi.it;
   isabella.taglieri@for.unipi.it; chiara.sanmartin@unipi.it;
   cristina.sgherri@unipi.it; marinella.deleo@unipi.it;
   ciccone3@student.unisi.it; sandra.donnini@unisi.it;
   francesca.venturi@unipi.it; luisa.pistelli@unipi.it;
   alma.martelli@unipi.it; vincenzo.calderone@unipi.it;
   lara.testai@unipi.it; angela.zinnai@unipi.it
RI Taglieri, Isabella/AAA-4892-2019; Ciccone, Valerio/AAT-1508-2021;
   Martelli, Alma/H-6557-2019; Donnini, Sandra/K-9252-2019; SANMARTIN,
   CHIARA/F-7524-2017; CALDERONE, VINCENZO/L-9288-2015; Sgherri,
   Cristina/L-3245-2017; Venturi, Francesca/O-8348-2016
OI Ciccone, Valerio/0000-0002-5374-9694; SANMARTIN,
   CHIARA/0000-0002-7559-1955; Monica, Macaluso/0000-0001-7075-4252; Flori,
   Lorenzo/0000-0001-7899-0954; Donnini, Sandra/0000-0001-6617-1644;
   Pistelli, Luisa/0000-0002-6898-6510; CALDERONE,
   VINCENZO/0000-0002-1441-5421; Sgherri, Cristina/0000-0003-3791-2743;
   Venturi, Francesca/0000-0002-7844-3253
FU Regione Toscana: NOE Project ("Progetti di ricerca e sviluppo delle
   MPMI", FESR 2014-2020) [CUP 7429.31052017.113000079]; Regione Toscana:
   VALE Project (Grant 1 "Progetti di ricerca e sviluppo", FESR 2014-2020)
   [CUP D56G18000160009]; Fondo Europeo di Sviluppo Regionale (FESR):
   project Italia-Francia Marittimo 2014-2020 MARE DI AGRUMI Tourist
   branding and biotechnologies for the development of enterprises on a
   common resource: CITRUS [CUP C26D16007240007]
FX This research was funded by Regione Toscana: NOE Project (Grant Numbers:
   "Progetti di ricerca e sviluppo delle MPMI", FESR 2014-2020, CUP
   7429.31052017.113000079) and VALE Project (Grant 1 "Progetti di ricerca
   e sviluppo", FESR 2014-2020, cod. CUP D56G18000160009). This research
   was also funded by Fondo Europeo di Sviluppo Regionale (FESR): project
   Italia-Francia Marittimo 2014-2020 MARE DI AGRUMI Tourist branding and
   biotechnologies for the development of enterprises on a common resource:
   CITRUS-[CUP C26D16007240007].
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NR 80
TC 16
Z9 17
U1 3
U2 13
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JUN
PY 2020
VL 12
IS 6
AR 1557
DI 10.3390/nu12061557
PG 30
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA ML1AA
UT WOS:000549206600001
PM 32471156
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Kaur, S
   Kingo, K
   Zilmer, M
AF Kaur, Sirje
   Kingo, Klli
   Zilmer, Mihkel
TI Psoriasis and Cardiovascular Risk-Do Promising New Biomarkers Have
   Clinical Impact?
SO MEDIATORS OF INFLAMMATION
LA English
DT Review
ID C-REACTIVE PROTEIN; PLASMA ADIPONECTIN LEVELS; LOW-DENSITY-LIPOPROTEIN;
   METABOLIC SYNDROME; THERAPEUTIC IMPLICATIONS; MYOCARDIAL-INFARCTION;
   SERUM ADIPONECTIN; OXIDATIVE STRESS; GROWTH-FACTOR; DISEASE
AB Epidemiological studies suggest an increased prevalence of cardiovascular disease (CVD) in patients with psoriasis (PS). Therefore, emphasis has lately been laid on the necessity for clinical evaluation of the risk of CVD in these patients. The systemic inflammatory markers C-reactive protein (CRP) and interleukin-(IL-) 6, which have long been used to predict future CVD in the general population, are increased manyfold in patients with PS. Lipid abnormalities characterized by elevated triglycerides, low HDL cholesterol, and higher concentrations of LDL cholesterol and its oxidized form are also prevalent in patients. There is a need for additional laboratory markers for the assessment of cardiovascular status of patients with PS. Due to frequent comorbid overweight and obesity, biologically active compounds produced by adipocytes may have an impact on monitoring the status of the cardiovascular system of patients with PS. For this purpose, two adipokines, adiponectin and leptin, have been most extensively studied. The review focuses on some inflammatory and oxidative stress aspects in patients with PS through the analysis of the impact of prominent adipokines and oxidized low-density lipoprotein (oxLDL) to assess their eligibility for clinical practice as markers of CVD risk in patients with PS.
C1 [Kaur, Sirje; Kingo, Klli] Univ Tartu, Inst Clin Med, Clin Dermatol, Tartu, Estonia.
   [Kaur, Sirje; Kingo, Klli] Tartu Univ Hosp, Clin Dermatol, 31 Raja St, EE-50417 Tartu, Estonia.
   [Zilmer, Mihkel] Univ Tartu, Ctr Excellence Genom & Translat Med, Dept Biochem, Inst Biomed & Translat Med, 19 Ravila St, EE-50411 Tartu, Estonia.
C3 University of Tartu; University of Tartu
RP Kaur, S (corresponding author), Univ Tartu, Inst Clin Med, Clin Dermatol, Tartu, Estonia.; Kaur, S (corresponding author), Tartu Univ Hosp, Clin Dermatol, 31 Raja St, EE-50417 Tartu, Estonia.
EM sirje.kaur@kliinikum.ee
RI Kingo, Külli/H-3603-2012; Stefanadis, Christodoulos/ABH-2232-2020
OI Kingo, Kulli/0000-0001-6301-9612; Stefanadis,
   Christodoulos/0000-0001-5974-6454
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NR 95
TC 19
Z9 19
U1 0
U2 0
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 0962-9351
EI 1466-1861
J9 MEDIAT INFLAMM
JI Mediat. Inflamm.
PY 2017
VL 2017
AR 7279818
DI 10.1155/2017/7279818
PG 8
WC Cell Biology; Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Immunology
GA FF4ND
UT WOS:000408926500001
PM 28947858
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU McCullough, AJ
AF McCullough, AJ
TI Pathophysiology of nonalcoholic steatohepatitis
SO JOURNAL OF CLINICAL GASTROENTEROLOGY
LA English
DT Article; Proceedings Paper
CT Symposium on Nonalcoholic Fatty Liver Diseases and Nonalcoholic
   Steatohepatitis
CY 2004
CL New York, NY
DE nonalcoholic fatty liver disease; nonalcoholic steatohepatitis; insulin
   resistance; lipid peroxidation
ID FATTY LIVER-DISEASE; NECROSIS-FACTOR-ALPHA; INTESTINAL BACTERIAL
   OVERGROWTH; NON-ALCOHOLIC STEATOHEPATITIS; HEPATIC CYTOCHROME-P450 2E1;
   INDUCED INSULIN-RESISTANCE; STELLATE CELL ACTIVATION;
   LIPID-PEROXIDATION; METABOLIC SYNDROME; OXIDATIVE STRESS
AB Nonalcoholic fatty liver disease (NAFLD) affects approximately 30% of adults and 20% of children in the United States. Nonalcoholic steatohepatitis (NASH) is its most severe histologic form and progresses to cirrhosis in 20% of these patients. Once developed, 30% to 40% of patients with NASH cirrhosis will experience a liver-related death. Consequently, it has become extremely important to understand the pathophysiology of NASH to develop sound therapeutic interventions. It is now recognized that nonhepatic mechanisms are largely responsible for the development of insulin resistance, which causes hepatic steatosis. Once developed, oxidative stress and diminished antioxidants within the liver initiate the progression from steatosis alone to NASH and ultimately to cirrhosis. However, not all patients progress to cirrhosis. As is the case for other common complex metabolic diseases, it is the interaction between the environment and genetics that will determine the phenotypic expression of NAFLD and NASH in each individual patient. Which of the pathophysiologic factors (which are discussed in this review), either alone or in combination, will eventually provide the basis for the most effective therapy has yet to be determined.
C1 Metrohlth Med Ctr, Schwartz Ctr Metab & Nutr, Cleveland, OH 44109 USA.
   Case Western Reserve Univ, Cleveland, OH 44106 USA.
C3 MetroHealth System; University System of Ohio; Case Western Reserve
   University
RP Metrohlth Med Ctr, Schwartz Ctr Metab & Nutr, 2500 Metrohlth Dr, Cleveland, OH 44109 USA.
EM ajm3@po.cwru.edu
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NR 224
TC 358
Z9 397
U1 0
U2 31
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0192-0790
EI 1539-2031
J9 J CLIN GASTROENTEROL
JI J. Clin. Gastroenterol.
PD MAR
PY 2006
VL 40
IS 3
SU S
BP S17
EP S29
PG 13
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Gastroenterology & Hepatology
GA 034CR
UT WOS:000236902900005
DA 2025-06-11
ER

PT J
AU Fontes, A
   Ramalho-Santos, J
   Zischka, H
   Azul, AM
AF Fontes, Adriana
   Ramalho-Santos, Joao
   Zischka, Hans
   Azul, Anabela Marisa
TI Mushrooms on the plate: Trends towards NAFLD treatment, health
   improvement and sustainable diets
SO EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
LA English
DT Review
DE gut-liver axis protection; liver-adipose tissue axis; mushrooms; NAFLD
   treatment; non-communicable diseases; sustainable healthy diets
ID FATTY LIVER-DISEASE; GANODERMA-LUCIDUM; METABOLIC SYNDROME; OXIDATIVE
   STRESS; CHEMICAL-COMPOSITION; PANELLUS-SEROTINUS; INSULIN-RESISTANCE;
   GRIFOLA-FRONDOSA; REDUCES OBESITY; FRUITING BODIES
AB Non-alcoholic fatty liver disease (NAFLD) is a most important cause of liver disease. Similar to other non-communicable diseases (NCD), such as obesity and type II diabetes mellitus, NAFLD can strongly affected by diet. Diet-related NCD and malnutrition are rising in all regions being a major cause of the global health, economic and environmental burdens. Mushrooms, important dietary components since the hunter-gathering communities, have increasingly gained momentum in biomedical research and therapeutics due to their interplay in metabolism traits. We emphasize here the beneficial effects of mushroom-enriched diets on the homeostasis of lipid and sugar metabolism, including their modulation, but also interfering with insulin metabolism, gut microbiota, inflammation, oxidative stress and autophagy. In this review, we describe the cellular and molecular mechanisms at the gut-liver axis and the liver-white adipose tissue (WAT) axis, that plausibly cause such positive modulation, and discuss the potential of mushroom-enriched diets to prevent or ameliorate NAFLD and related NCD, also within the shift needed towards healthy sustainable diets.
C1 [Fontes, Adriana; Zischka, Hans] German Res Ctr Environm Hlth, Helmholtz Ctr Munich, Inst Mol Toxicol & Pharmacol, Neuherberg, Germany.
   [Fontes, Adriana; Ramalho-Santos, Joao; Azul, Anabela Marisa] Univ Coimbra, CNC Ctr Neurosci & Cell Biol, Coimbra, Portugal.
   [Fontes, Adriana; Ramalho-Santos, Joao] Univ Coimbra, DCV Dept Life Sci, Coimbra, Portugal.
   [Ramalho-Santos, Joao; Azul, Anabela Marisa] Univ Coimbra, CIBB Ctr Innovat Biomed & Biotechnol, Coimbra, Portugal.
   [Zischka, Hans] Tech Univ Munich, Inst Toxicol & Environm Hyg, Sch Med, Munich, Germany.
C3 Helmholtz Association; Helmholtz-Center Munich - German Research Center
   for Environmental Health; Universidade de Coimbra; Universidade de
   Coimbra; Universidade de Coimbra; Technical University of Munich
RP Azul, AM (corresponding author), Univ Coimbra, CNC Ctr Neurosci & Cell Biol, Coimbra, Portugal.; Azul, AM (corresponding author), Univ Coimbra, CIBB Ctr Innovat Biomed & Biotechnol, Coimbra, Portugal.
EM amjrazul@ci.uc.pt
RI Zischka, Hans/M-1490-2017; Azul, Anabela Marisa/AFP-5802-2022;
   Ramalho-Santos, Joao/F-8641-2012
OI Zischka, Hans/0000-0002-4047-1566; Azul, Anabela
   Marisa/0000-0003-3295-1284; Ramalho-Santos, Joao/0000-0002-1172-4018;
   Fontes, Adriana/0000-0003-0923-9053
FU H2020 Marie Sklodowska-Curie Actions [722619, 734719]; FOIE GRAS
   project; mtFOIE GRAS project; Marie Curie Actions (MSCA) [734719,
   722619] Funding Source: Marie Curie Actions (MSCA)
FX H2020 Marie Sklodowska-Curie Actions, Grant/Award Number: ID: 722619,
   ID: 734719; FOIE GRAS and mtFOIE GRAS projects
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NR 113
TC 5
Z9 5
U1 1
U2 18
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0014-2972
EI 1365-2362
J9 EUR J CLIN INVEST
JI Eur. J. Clin. Invest.
PD MAR
PY 2022
VL 52
IS 3
SI SI
AR e13667
DI 10.1111/eci.13667
EA SEP 2021
PG 20
WC Medicine, General & Internal; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Research & Experimental Medicine
GA YY0CT
UT WOS:000696863800001
PM 34390493
OA Green Published
DA 2025-06-11
ER

PT J
AU Hocher, B
   Adamski, J
AF Hocher, Berthold
   Adamski, Jerzy
TI Metabolomics for clinical use and research in chronic kidney disease
SO NATURE REVIEWS NEPHROLOGY
LA English
DT Review
ID 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1; SERUM CYSTATIN-C; OXIDATIVE
   STRESS; L-CARNITINE; AMINO-ACID; BIOMARKER DISCOVERY; PROFILING REVEALS;
   ARISTOLOCHIC ACID; WIDE ASSOCIATION; FUNCTION DECLINE
AB Chronic kidney disease (CKD) has a high prevalence in the general population and is associated with high mortality; a need therefore exists for better biomarkers for diagnosis, monitoring of disease progression and therapy stratification. Moreover, very sensitive biomarkers are needed in drug development and clinical research to increase understanding of the efficacy and safety of potential and existing therapies. Metabolomics analyses can identify and quantify all metabolites present in a given sample, covering hundreds to thousands of metabolites. Sample preparation for metabolomics requires a very fast arrest of biochemical processes. Present key technologies for metabolomics are mass spectrometry and proton nuclear magnetic resonance spectroscopy, which require sophisticated biostatistic and bioinformatic data analyses. The use of metabolomics has been instrumental in identifying new biomarkers of CKD such as acylcarnitines, glycerolipids, dimethylarginines and metabolites of tryptophan, the citric acid cycle and the urea cycle. Biomarkers such as c-mannosyl tryptophan and pseudouridine have better performance in CKD stratification than does creatinine. Future challenges in metabolomics analyses are prospective studies and deconvolution of CKD biomarkers from those of other diseases such as metabolic syndrome, diabetes mellitus, inflammatory conditions, stress and cancer.
C1 [Hocher, Berthold] Hunan Univ, Coll Med, Dept Basic Med, Changsha 410006, Hunan, Peoples R China.
   [Adamski, Jerzy] Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Genome Anal Ctr, Inst Expt Genet, Ingolstaedter Landstr 1, D-85764 Neuherberg, Germany.
C3 Hunan University; Helmholtz Association; Helmholtz-Center Munich -
   German Research Center for Environmental Health
RP Adamski, J (corresponding author), Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Genome Anal Ctr, Inst Expt Genet, Ingolstaedter Landstr 1, D-85764 Neuherberg, Germany.
EM adamski@helmholtz-muenchen.de
RI Hocher, Berthold/AAC-3510-2020
OI Hocher, Berthold/0000-0001-8143-0579; Adamski, Jerzy/0000-0001-9259-0199
FU Innovative Medicines Initiative Joint Undertaking [115439, 115317];
   German Federal Ministry of Education and Research (BMBF); Deutsche
   Forschungsgemeinschaft (DFG) [Ho 1665/5-1, Ho 1665/5-2, Ho 1665/5-3]
FX The authors' work is supported by Innovative Medicines Initiative Joint
   Undertaking under Grant agreement number 115439 (StemBANCC), and number
   115317 (DIRECT), the German Federal Ministry of Education and Research
   (BMBF) to the German Center Diabetes Research (DZD e.V.) grant to J.A.
   and the Deutsche Forschungsgemeinschaft (DFG) number Ho 1665/5-1, Ho
   1665/5-2 and Ho 1665/5-3 to B.H. The authors would like to express their
   gratitude for critical reading of the manuscript to Dr. Cornelia Prehn
   and Dr. Alexander Cecil at Helmholtz Zentrum Munchen, Genome Analysis
   Center, Neuherberg, Germany.
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NR 192
TC 261
Z9 279
U1 12
U2 333
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 1759-5061
EI 1759-507X
J9 NAT REV NEPHROL
JI Nat. Rev. Nephrol.
PD MAY
PY 2017
VL 13
IS 5
BP 269
EP 284
DI 10.1038/nrneph.2017.30
PG 16
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA ER7OR
UT WOS:000399003200004
PM 28262773
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Nomura, K
   Yamanouchi, T
AF Nomura, Kyoko
   Yamanouchi, Toshikazu
TI The role of fructose-enriched diets in mechanisms of nonalcoholic fatty
   liver disease
SO JOURNAL OF NUTRITIONAL BIOCHEMISTRY
LA English
DT Review
DE Fructose; Nonalcoholic fatty liver disease (NAFLD); Nonalcoholic
   steatohepatitis (NASH); Review
ID CARNITINE PALMITOYLTRANSFERASE-I; INDUCED HEPATIC STEATOSIS; DE-NOVO
   LIPOGENESIS; NF-KAPPA-B; INSULIN-RESISTANCE; BINDING PROTEIN;
   NITRIC-OXIDE; OXIDATIVE STRESS; APOLIPOPROTEIN-B; RISK-FACTOR
AB Nonalcoholic fatty liver disease (NAFLD) currently affects 20%-30% of adults and 10% of children in industrialized countries, and its prevalence is increasing worldwide. Although NAFLD is a benign form of liver dysfunction, it can proceed to a more serious condition, nonalcoholic steatohepatitis (NASH), which may lead to liver cirrhosis and hepatocellular carcinoma. NAFLD is accompanied by obesity, metabolic syndrome and diabetes mellitus, and evidence suggests that fructose, a major caloric sweetener in the diet, plays a significant role in its pathogenesis. Inflammatory progression to NASH is proposed to occur by a two-hit process. The first "hit" is hepatic fat accumulation owing to increased hepatic de novo lipogenesis, inhibition of fatty acid beta oxidation, impaired triglyceride clearance and decreased very-low-density lipoprotein export. The mechanisms of the second "hit" are still largely unknown, but recent studies suggest several possibilities, including inflammation caused by oxidative stress associated with lipid peroxidation, cytokine activation, nitric oxide and reactive oxygen species, and endogenous toxins of fructose metabolites. (C) 2012 Elsevier Inc. All rights reserved.
C1 [Nomura, Kyoko] Teikyo Univ, Dept Hyg & Publ Hlth, Sch Med, Tokyo 1838605, Japan.
   [Yamanouchi, Toshikazu] Teikyo Univ Hosp, Dept Internal Med, Teikyo, Japan.
C3 Teikyo University; Teikyo University
RP Nomura, K (corresponding author), Teikyo Univ, Dept Hyg & Publ Hlth, Sch Med, Tokyo 1838605, Japan.
EM DZB07241@nifty.ne.jp
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NR 93
TC 172
Z9 191
U1 2
U2 44
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0955-2863
EI 1873-4847
J9 J NUTR BIOCHEM
JI J. Nutr. Biochem.
PD MAR
PY 2012
VL 23
IS 3
BP 203
EP 208
DI 10.1016/j.jnutbio.2011.09.006
PG 6
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA 900TX
UT WOS:000300914200001
PM 22129639
OA Bronze
DA 2025-06-11
ER

PT J
AU O'Keefe, JH
   Bell, DSH
AF O'Keefe, James H.
   Bell, David S. H.
TI Postprandial Hyperglycemia/Hyperlipidemia (Postprandial dysmetabolism)
   is a cardiovascular risk factor
SO AMERICAN JOURNAL OF CARDIOLOGY
LA English
DT Review
ID TYPE-2 DIABETIC-PATIENTS; IMPAIRED GLUCOSE-TOLERANCE;
   CORONARY-HEART-DISEASE; OXIDATIVE STRESS; ENDOTHELIAL DYSFUNCTION;
   BLOOD-GLUCOSE; FASTING TRIGLYCERIDES; MYOCARDIAL-INFARCTION;
   INSULIN-RESISTANCE; METABOLIC SYNDROME
AB Epidemiologic data indicate that a postprandial state characterized by abnormally increased levels of glucose and lipids (also referred to as postprandial dysmetabolism) is an independent predictor of future cardiovascular events, even in nondiabetic subjects. The cardiovascular toxicity of postprandial dysmetabolism is mediated by oxidant stress, which is directly proportional to the increase in glucose after a meal. This transient increase in free radicals acutely triggers inflammation, endothelial dysfunction, hypercoagulability, sympathetic hyperactivity, and a cascade of other atherogenic changes. The postprandial dysmetabolism hypothesis has been bolstered by interventional studies that have demonstrated that blunting the postprandial spikes in glucose and lipids improves inflammation and endothelial function immediately. Early randomized controlled trials indicate that reducing postprandial dysmetabolism appears to significantly slow atherosclerotic progression and may improve cardiovascular prognosis. In conclusion, postprandial dysmetabolism appears to be an important proximate cause of adverse cardiovascular events. Addressing this fundamental and largely unrecognized condition will require specific screening and treatment strategies. Diet, exercise, and various pharmacologic agents can improve postprandial dysmetabolism. Using these strategies may help improve the prognosis for patients with diabetes mellitus and/or coronary heart disease. (c) 2007 Elsevier Inc. All rights reserved. (Am J Cardiol 2007;100:899-904)
C1 Univ Missouri, Kansas City, MO 64110 USA.
   St Lukes Hosp, Mid Amer Heart Inst, Kansas City, MO 64111 USA.
   Univ Alabama, Birmingham, AL USA.
C3 University of Missouri System; University of Missouri Kansas City; Saint
   Luke's Mid America Heart Institute; Saint Luke's Hospital - Missouri;
   University of Alabama System; University of Alabama Birmingham
RP O'Keefe, JH (corresponding author), Univ Missouri, Kansas City, MO 64110 USA.
EM jhokeefe@cc-pc.com
OI O'Keefe, James/0000-0002-3376-5822
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NR 53
TC 437
Z9 477
U1 0
U2 43
PU EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
PI BRIDGEWATER
PA 685 ROUTE 202-206 STE 3, BRIDGEWATER, NJ 08807 USA
SN 0002-9149
EI 1879-1913
J9 AM J CARDIOL
JI Am. J. Cardiol.
PD SEP 1
PY 2007
VL 100
IS 5
BP 899
EP 904
DI 10.1016/j.amjcard.2007.03.107
PG 6
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 207BH
UT WOS:000249226100029
PM 17719342
DA 2025-06-11
ER

PT J
AU Arai, N
   Miura, K
   Aizawa, K
   Sekiya, M
   Nagayama, M
   Sakamoto, H
   Maeda, H
   Morimoto, N
   Iwamoto, S
   Yamamoto, H
AF Arai, Naoshi
   Miura, Kouichi
   Aizawa, Kenichi
   Sekiya, Mariko
   Nagayama, Manabu
   Sakamoto, Hirotsugu
   Maeda, Hiroshi
   Morimoto, Naoki
   Iwamoto, Sadahiko
   Yamamoto, Hironori
TI Probiotics suppress nonalcoholic steatohepatitis and carcinogenesis
   progression in hepatocyte-specific PTEN knockout mice
SO SCIENTIFIC REPORTS
LA English
DT Article
ID FATTY LIVER-DISEASE; GUT MICROBIOTA; HEPATOCELLULAR-CARCINOMA;
   LACTOBACILLUS; EXPRESSION; DIET; INFLAMMATION; CHOLESTEROL; DEFICIENCY;
   FIBROSIS
AB Nonalcoholic fatty liver disease (NAFLD), a hepatic characteristic of metabolic syndrome, received significant attention in clinical settings. The multiple-hit theory is one of the proposed mechanisms of NAFLD, and gut dysbiosis is considered a hit. Thus, controlling gut microbiota is a potential target in the management of NAFLD, and probiotics can be used as a treatment agent for NAFLD. The current study aimed to investigate the efficacy of probiotics against nonalcoholic steatohepatitis in a hepatocyte-specific PTEN knockout mouse model that mimics the characteristics of human NAFLD. Probiotics were administered to male knockout mice for 8 or 40 weeks. Next, we assessed hepatic inflammation, fibrosis, carcinogenesis, and oxidative stress. Probiotics were found to reduce serum transaminase levels, NAFLD activity score, and the gene expression of pro-inflammatory cytokines. In addition, they decreased liver fibrosis grade, which was examined via Sirius red staining, gene expression of fibrotic markers, and hydroxyproline. Furthermore, probiotics suppressed the number of liver tumors, particular in HCC. Probiotics reduced oxidative stresses, including glutathione levels, and anti-oxidative stress marker, which may be an underlying mechanism for their beneficial effects. In conclusion, probiotics treatment had beneficial effects against NAFLD and carcinogenesis in hepatocyte-specific PTEN knockout mice.
C1 [Arai, Naoshi; Miura, Kouichi; Sekiya, Mariko; Nagayama, Manabu; Sakamoto, Hirotsugu; Maeda, Hiroshi; Morimoto, Naoki; Yamamoto, Hironori] Jichi Med Univ, Dept Med, Div Gastroenterol, 3311-1 Yakushiji Shimotsuke, Shimotsuke, Tochigi 3290498, Japan.
   [Aizawa, Kenichi] Jichi Med Univ, Dept Pharmacol, Div Clin Pharmacol, 3311-1 Yakushiji Shimotsuke, Shimotsuke, Tochigi 3290498, Japan.
   [Iwamoto, Sadahiko] Jichi Med Univ, Ctr Community Med, Div Human Genet, 3311-1 Yakushiji Shimotsuke, Shimotsuke, Tochigi 3290498, Japan.
C3 Jichi Medical University; Jichi Medical University; Jichi Medical
   University
RP Miura, K (corresponding author), Jichi Med Univ, Dept Med, Div Gastroenterol, 3311-1 Yakushiji Shimotsuke, Shimotsuke, Tochigi 3290498, Japan.; Aizawa, K (corresponding author), Jichi Med Univ, Dept Pharmacol, Div Clin Pharmacol, 3311-1 Yakushiji Shimotsuke, Shimotsuke, Tochigi 3290498, Japan.
EM miura385@jichi.ac.jp; aizawa@jichi.ac.jp
RI Nagayama, Manabu/JPW-9057-2023; Sakamoto, Hirotsugu/G-6426-2013
OI Sakamoto, Hirotsugu/0000-0002-2458-1693
FU Grants-in-Aid for Scientific Research [22K08016] Funding Source: KAKEN
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NR 40
TC 21
Z9 21
U1 2
U2 11
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD SEP 28
PY 2022
VL 12
IS 1
AR 16206
DI 10.1038/s41598-022-20296-3
PG 12
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 4Z1AV
UT WOS:000861951000057
PM 36171333
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Lien, CF
   Chen, SJ
   Tsai, MC
   Lin, CS
AF Lien, Chih-Feng
   Chen, Sy-Jou
   Tsai, Min-Chien
   Lin, Chin-Sheng
TI Potential Role of Protein Kinase C in the Pathophysiology of
   Diabetes-Associated Atherosclerosis
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Review
DE PKC; atherosclerosis; diabetes; hyperglycemia; inflammation; plaque
   evolution
ID LOW-DENSITY-LIPOPROTEIN; SMOOTH-MUSCLE-CELLS; PKC-DELTA;
   ENDOTHELIAL-CELLS; CHOLESTEROL EFFLUX; HIGH GLUCOSE; MATRIX
   METALLOPROTEINASES; RECEPTOR TRANSCRIPTION; SUPEROXIDE-PRODUCTION;
   SCAVENGER RECEPTORS
AB Diabetes mellitus is a metabolic syndrome that affects millions of people worldwide. Recent studies have demonstrated that protein kinase C (PKC) activation plays an important role in hyperglycemia-induced atherosclerosis. PKC activation is involved in several cellular responses such as the expression of various growth factors, activation of signaling pathways, and enhancement of oxidative stress in hyperglycemia. However, the role of PKC activation in pro-atherogenic and anti-atherogenic mechanisms remains controversial, especially under hyperglycemic condition. In this review, we discuss the role of different PKC isoforms in lipid regulation, oxidative stress, inflammatory response, and apoptosis. These intracellular events are linked to the pathogenesis of atherosclerosis in diabetes. PKC deletion or treatment with PKC inhibitors has been studied in the regulation of atherosclerotic plaque formation and evolution. Furthermore, some preclinical and clinical studies have indicated that PKC beta and PKC delta are potential targets for the treatment of diabetic vascular complications. The current review summarizes these multiple signaling pathways and cellular responses regulated by PKC activation and the potential therapeutic targets of PKC in diabetic complications.
C1 [Lien, Chih-Feng; Lin, Chin-Sheng] Natl Def Med Ctr, Triserv Gen Hosp, Dept Med, Div Cardiol, Taipei, Taiwan.
   [Chen, Sy-Jou] Natl Def Med Ctr, Triserv Gen Hosp, Dept Emergency Med, Taipei, Taiwan.
   [Tsai, Min-Chien] Natl Def Med Ctr, Grad Inst Physiol, Dept Physiol & Biophys, Taipei, Taiwan.
C3 Tri-Service General Hospital; National Defense Medical Center;
   Tri-Service General Hospital; National Defense Medical Center; National
   Defense Medical Center
RP Lin, CS (corresponding author), Natl Def Med Ctr, Triserv Gen Hosp, Dept Med, Div Cardiol, Taipei, Taiwan.; Tsai, MC (corresponding author), Natl Def Med Ctr, Grad Inst Physiol, Dept Physiol & Biophys, Taipei, Taiwan.
EM mctsai6108@gmail.com; littlelincs@gmail.com
OI Lin, Chin-Sheng/0000-0002-5167-8327; Lien, Chih-Feng/0009-0006-5598-9751
FU Taiwan Ministry of Science and Technology [MOST 109-2314-B-016-042-MY3,
   MOST 109-2314-B-016-044, MOST 109-2320-B-016-003-MY2]; Tri-Service
   General Hospital [TSGH-E-110188]; Kaohsiung Armed Forces General
   Hospital [802KB109607]; Ministry of National Defense-Medical Affairs
   Bureau [MAB-109-069]
FX This research was funded by grants from the Taiwan Ministry of Science
   and Technology (MOST 109-2314-B-016-042-MY3 to C-SL, MOST
   109-2314-B-016-044 to S-JC and MOST 109-2320-B-016-003-MY2 to M-CT),
   Tri-Service General Hospital (TSGH-E-110188 to C-SL), Kaohsiung Armed
   Forces General Hospital (802KB109607 to C-SL) and Ministry of National
   Defense-Medical Affairs Bureau (MAB-109-069 to M-CT).
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NR 98
TC 51
Z9 55
U1 2
U2 12
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD JUL 2
PY 2021
VL 12
AR 716332
DI 10.3389/fphar.2021.716332
PG 12
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA TK2BQ
UT WOS:000673970900001
PM 34276388
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Navarro-Hortal, MD
   Varela-López, A
   Romero-Márquez, JM
   Piquer-Martinez, C
   Bullón, P
   Forbes-Hernández, TY
   Quiles, JL
AF Navarro-Hortal, Maria D.
   Varela-Lopez, Alfonso
   Romero-Marquez, Jose M.
   Piquer-Martinez, Celia
   Bullon, Pedro
   Forbes-Hernandez, Tamara Y.
   Quiles, Jose L.
TI Twenty-four Months Feeding on Unsaturated Dietary Fats (Virgin Olive,
   Sunflower, or Fish Oil) Differentially Modulate Gingival Mitochondria in
   the Rat
SO EFOOD
LA English
DT Article
DE Aging; fatty acids; gene expression; biogenesis; autophagy; apoptosis
ID METABOLIC SYNDROME; OXIDATIVE STRESS; LIVER; ACIDS; PATHOGENESIS;
   NUTRITION; DEPENDS; DISEASE; HEALTH
AB This study investigated the effects of feeding rats for 24 months on different unsaturated fats (virgin olive, sunflower, or fish oil) on gingival mitochondrial ultrastructure and expression of genes related to mitochondrial biology as well as the amount of circulating fatty acids in the plasma. Results show that sunflower oil led to a higher mitochondrial area, perimeter, and area:perimeter ratio, markers of swelling, and increased age. Sunflower oil also led to increased gene expression associated to biogenesis, autophagy, oxidative stress, and apoptosis. Genes related to mitochondrial electron chain did not result affected by treatments. As old rats lifelong fed on sunflower oil have previously showed higher alveolar bone resorption, a major feature of periodontitis, we could conclude that age-related alveolar bone resorption associated with n6PUFA would be, at least in part, mediated by changes in mitochondrial ultrastructure and gene expression at the gingival tissue. (c) 2019 International Association of Dietetic Nutrition and Safety. Publishing services by Atlantis Press International B.V. This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).
C1 [Navarro-Hortal, Maria D.; Varela-Lopez, Alfonso; Romero-Marquez, Jose M.; Piquer-Martinez, Celia; Quiles, Jose L.] Univ Granada, Inst Nutr & Food Technol Jose Mataix Verdu, Dept Physiol, Biomed Res Ctr, Avda Conocimiento SN, Armilla 18100, Granada, Spain.
   [Bullon, Pedro] Univ Seville, Dept Oral Med & Periodontol, Seville, Spain.
   [Forbes-Hernandez, Tamara Y.] Univ Vigo, Dept Analyt & Food Chem, Nutr & Food Sci Grp, CITACA,CACTI, Vigo, Spain.
C3 University of Granada; University of Sevilla; Universidade de Vigo
RP Quiles, JL (corresponding author), Univ Granada, Inst Nutr & Food Technol Jose Mataix Verdu, Dept Physiol, Biomed Res Ctr, Avda Conocimiento SN, Armilla 18100, Granada, Spain.
EM jlquiles@ugr.es
RI Forbes Hernandez, Tamara/AAB-1872-2021; Navarro-Hortal,
   María/AAB-9805-2019; Quiles, José/C-6911-2013; Battino,
   Maurizio/E-6103-2012; Piquer, Celia/ITV-9681-2023; Romero Marquez, Jose
   Manuel/AAH-6806-2020; Varela-Lopez, Alfonso/F-8055-2016
OI Romero Marquez, Jose Manuel/0000-0001-7033-969X; Varela-Lopez,
   Alfonso/0000-0002-0504-5086; Navarro-Hortal, Maria
   D./0000-0002-6225-8379
FU Spanish Ministry of Education and Science [AGL2008-01057]; Government of
   Andalusia [AGR832]; Spanish Ministry of Educacion y Formacion
   Profesional
FX This work was supported by I + D grants from the Spanish Ministry of
   Education and Science [AGL2008-01057] and the Government of Andalusia
   [AGR832]. Maria D. Navarro-Hortal and Jose M. Romero-Marquez are FPU
   fellows from the Spanish Ministry of Educacion y Formacion Profesional.
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NR 36
TC 5
Z9 5
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
EI 2666-3066
J9 EFOOD
JI eFood
PD FEB
PY 2020
VL 1
IS 1
BP 61
EP 68
DI 10.2991/efood.k.190802.002
PG 8
WC Food Science & Technology
WE Emerging Sources Citation Index (ESCI)
SC Food Science & Technology
GA LK8L9
UT WOS:001186785100007
OA gold
DA 2025-06-11
ER

PT J
AU Guo, HH
   Ling, WH
   Wang, Q
   Liu, C
   Hu, Y
   Xia, M
   Feng, X
   Xia, XD
AF Guo, Honghui
   Ling, Wenhua
   Wang, Qing
   Liu, Chi
   Hu, Yan
   Xia, Min
   Feng, Xiang
   Xia, Xiaodong
TI Effect of anthocyanin-rich extract from black rice (Oryza sativa
   L. indica) on hyperlipidemia and insulin resistance in
   fructose-fed rats
SO PLANT FOODS FOR HUMAN NUTRITION
LA English
DT Article
DE anthocyanin; black rice; hyperlipidemia; insulin resistance; metabolic
   syndrome; oxidative stress
ID ATHEROSCLEROTIC PLAQUE-FORMATION; FRACTION; GLUCOSE; SUPPLEMENTATION;
   OBESITY; WEIGHT; DIETS
AB This study was designed to evaluate the effect of an anthocyanin-rich extract from black rice on hyperlipidemia and insulin resistance in fructose-fed rats. Rats fed fructose diet for 4 weeks exhibited significantly higher plasma insulin levels and lower insulin sensitivity than the control rats fed AIN-93G diet. Dietary supplementation with the anthocyanin-rich extract (5 g/kg of high-fructose diet) prevented the development of fructose-induced insulin resistance. After fructose-induced insulin resistance had been established, 4-week treatment with the anthocyanin-rich extract (5 g/kg of high-fructose diet) or pioglitazone (270 mg/kg of high-fructose diet) ameliorated the glucose intolerance and hyperlipidemia, but the extract failed to reverse the fructose-induced hyperinsulinemia as pioglitazone did. In addition, rats supplemented by the extract exhibited lower oxidative stress than the fructose-fed controls, as indicated by the lower concentrations of plasma thiobarbituric acid reactive substances and blood oxidized glutathione. Overall, these results suggest that the anthocyanin-rich extract from black rice improves certain metabolic abnormalities associated with diets high in fructose.
C1 Sun Yat Sen Univ, Sch Publ Hlth, Dept Nutr, Guangzhou 510080, Guangdong, Peoples R China.
C3 Sun Yat Sen University
RP Ling, WH (corresponding author), Sun Yat Sen Univ, Sch Publ Hlth, Dept Nutr, Northern Campus,74 Zhongshan Rd 2, Guangzhou 510080, Guangdong, Peoples R China.
EM lingwh@mail.sysu.edu.cn
RI Xia, Xiaodong/R-9279-2019; Guo, Honghui/J-6355-2014
OI Guo, Honghui/0000-0001-7837-0392
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NR 28
TC 128
Z9 161
U1 1
U2 53
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0921-9668
EI 1573-9104
J9 PLANT FOOD HUM NUTR
JI Plant Food Hum. Nutr.
PD MAR
PY 2007
VL 62
IS 1
BP 1
EP 6
DI 10.1007/s11130-006-0031-7
PG 6
WC Plant Sciences; Chemistry, Applied; Food Science & Technology; Nutrition
   & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Chemistry; Food Science & Technology; Nutrition &
   Dietetics
GA 139RZ
UT WOS:000244451600001
PM 17187297
DA 2025-06-11
ER

PT J
AU Tuncman, G
   Hirosumi, J
   Solinas, G
   Chang, LF
   Karin, M
   Hotamisligil, GS
AF Tuncman, Gurol
   Hirosumi, Jiro
   Solinas, Giovanni
   Chang, Lufen
   Karin, Michael
   Hotamisligil, Gokhan S.
TI Functional in vivo interactions between JNK1 and JNK2 isoforms in
   obesity and insulin resistance
SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF
   AMERICA
LA English
DT Article
DE diabetes; fatty liver; metabolic syndrome; inflammation; stress
ID NECROSIS-FACTOR-ALPHA; ENDOPLASMIC-RETICULUM STRESS; TNF-ALPHA; RECEPTOR
   SUBSTRATE-1; TARGETED DISRUPTION; KINASE; ACTIVATION; PHOSPHORYLATION;
   DIFFERENTIATION; INFLAMMATION
AB The c-Jun N-terminal kinases (JNKs) are key regulators of inflammation and interfere with insulin action in cultured cells and whole animals. Obesity increases total JNK activity, and JNK1, but not JNK2, deficiency results in reduced adiposity and improved insulin sensitivity. Interestingly, a higher-than-normal level of JNK activation is observed in Jnk2(-/-) mice, particularly in the liver, indicating an interaction between the isoforms that might have masked the metabolic activity of JNK2 in isolated mutant mice. To address the role of the JNK2 isoform in metabolic homeostasis, we intercrossed Jnk1(-/-) and Jnk2(-/-) mice and examined body weight and glucose metabolism in the resulting mutant allele combinations. Among all of the viable genotypes examined, we observed only reduced body weight and increased insulin sensitivity in Jnk1(-/-) and Jnk1(+/-)Jnk2(-/-) mice. These two groups of mice also exhibited reduced total JNK activity and cytokine expression in liver tissue compared with all other genotypes examined. These data indicate that the JNK2 isoform is also involved in metabolic regulation, but its function is not obvious when JNK1 is fully expressed because of regulatory crosstalk between the two isoforms.
C1 Univ Calif San Diego, Dept Pharmacol, Lab Gene Regulat & Signal Transduct, Sch Med, La Jolla, CA 92093 USA.
   Harvard Univ, Sch Publ Hlth, Dept Genet & Complex Dis, Boston, MA 02115 USA.
C3 University of California System; University of California San Diego;
   Harvard University; Harvard T.H. Chan School of Public Health
RP Karin, M (corresponding author), Univ Calif San Diego, Dept Pharmacol, Lab Gene Regulat & Signal Transduct, Sch Med, La Jolla, CA 92093 USA.
EM mkarin@ucsd.edu; ghotamis@hsph.harvard.edu
RI Hotamisligil, Gokhan/ABL-2919-2022; Solinas, Giovanni/R-4777-2019;
   Solinas, Giovanni/P-6596-2017; Tuncman, Gurol/IRZ-4487-2023
OI Solinas, Giovanni/0000-0002-0140-2621; Tuncman,
   Gurol/0000-0002-6124-5955
FU NIDDK NIH HHS [R01 DK052539, P30 DK040561, DK52539] Funding Source:
   Medline; NIEHS NIH HHS [R37 ES004151, ES04151] Funding Source: Medline
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NR 31
TC 283
Z9 340
U1 0
U2 21
PU NATL ACAD SCIENCES
PI WASHINGTON
PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA
SN 0027-8424
J9 P NATL ACAD SCI USA
JI Proc. Natl. Acad. Sci. U. S. A.
PD JUL 11
PY 2006
VL 103
IS 28
BP 10741
EP 10746
DI 10.1073/pnas.0603509103
PG 6
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 063VG
UT WOS:000239047400037
PM 16818881
OA Green Published
DA 2025-06-11
ER

PT J
AU Wei, WY
   Qin, F
   Gao, JJ
   Chang, JL
   Pan, XJ
   Jiang, XM
   Che, LQ
   Zhuo, Y
   Wu, D
   Xu, SY
AF Wei, Wenyan
   Qin, Feng
   Gao, Junjie
   Chang, Junlei
   Pan, Xujing
   Jiang, Xuemei
   Che, Lianqiang
   Zhuo, Yong
   Wu, De
   Xu, Shengyu
TI The effect of maternal consumption of high-fat diet on ovarian
   development in offspring
SO ANIMAL REPRODUCTION SCIENCE
LA English
DT Article
DE Maternal high -fat diet; Offspring; Ovarian development; Oxidative
   status; Apoptosis
ID GONADOTROPIN GENE-EXPRESSION; X-LINKED INHIBITOR; NF-KAPPA-B; OXIDATIVE
   STRESS; INSULIN-RESISTANCE; FOLLICULAR-FLUID; GRANULOSA-CELLS;
   MESSENGER-RNA; FEMALE; APOPTOSIS
AB The environment encountered by the fetus during its development exerts a profound influence on its physiological function and disease risk in adulthood. Women's intake of high-fat diet during pregnancy and lactation has gradually become an issue of widespread concern. Maternal high-fat diet will not only cause abnormal neurological development and metabolic syndrome symptoms in the offspring, but also affect the fertility of female offspring. Maternal high-fat diet affects the expression of genes related to follicle growth in offspring, such as AAT, AFP and GDF-9, which reduces the number of follicles and impairs follicle development. Additionally, maternal high-fat diet also affects ovarian health by inducing ovarian oxidative stress and cell apoptosis, which collectively can impair the reproductive potential of female offspring. Reproductive potential carries significant importance for both humans and animals. Therefore, this review aims to describe the effect of maternal exposure to high-fat diet on the ovarian development of offspring and to discuss possible mechanisms by which maternal diet affects the growth and metabolism of offspring.
C1 [Wei, Wenyan; Qin, Feng; Gao, Junjie; Chang, Junlei; Pan, Xujing; Jiang, Xuemei; Che, Lianqiang; Zhuo, Yong; Wu, De; Xu, Shengyu] Sichuan Agr Univ, Minist Agr & Rural Affairs, Anim Nutr Inst, Key Lab Sichuan Prov,Anim Dis Resistance Nutr,Mini, Sichuan 611130, Peoples R China.
C3 Ministry of Agriculture & Rural Affairs; Sichuan Agricultural University
RP Xu, SY (corresponding author), Sichuan Agr Univ, Minist Agr & Rural Affairs, Anim Nutr Inst, Key Lab Sichuan Prov,Anim Dis Resistance Nutr,Mini, Sichuan 611130, Peoples R China.
EM shengyuxu@sicau.edu.cn
RI junjie, gao/AFW-1181-2022; Jiang, Xuemei/HSH-3217-2023; Xu,
   Shengyu/AFN-8288-2022; Qin, Feng/JWP-5386-2024; Chang,
   Junlei/K-2696-2017
OI Wu, De/0000-0003-1873-9914
FU Major Scientific and Technological Special Project of Sichuan Province
   [2021ZDZX0009]; National Natural Science Foundation of China [32102554];
   Natural Science Foundation of Sichuan Province [2022NSFSC1628]; Sichuan
   Province "145" Breeding Tackle Project [2021YFYZ0008]
FX This research was funded by Major Scientific and Technological Special
   Project of Sichuan Province (No. 2021ZDZX0009) , National Natural
   Science Foundation of China (32102554) , Natural Science Foundation of
   Sichuan Province (2022NSFSC1628) , Sichuan Province "145" Breeding
   Tackle Project (2021YFYZ0008) .
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NR 83
TC 15
Z9 15
U1 1
U2 8
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0378-4320
EI 1873-2232
J9 ANIM REPROD SCI
JI Anim. Reprod. Sci.
PD AUG
PY 2023
VL 255
AR 107294
DI 10.1016/j.anireprosci.2023.107294
EA JUL 2023
PG 10
WC Agriculture, Dairy & Animal Science; Reproductive Biology; Veterinary
   Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture; Reproductive Biology; Veterinary Sciences
GA N7ZW9
UT WOS:001039159800001
PM 37421833
OA hybrid
DA 2025-06-11
ER

PT J
AU Zhang, Y
   Cheng, Y
   Liu, J
   Zuo, JH
   Yan, LP
   Thring, RW
   Ba, XQ
   Qi, DK
   Wu, MJ
   Gao, YT
   Tong, HB
AF Zhang, Ya
   Cheng, Yang
   Liu, Jian
   Zuo, Jihui
   Yan, Liping
   Thring, Ronald W.
   Ba, Xueqing
   Qi, Dake
   Wu, Mingjiang
   Gao, Yitian
   Tong, Haibin
TI Tauroursodeoxycholic acid functions as a critical effector mediating
   insulin sensitization of metformin in obese mice
SO REDOX BIOLOGY
LA English
DT Article
DE Metformin; Insulin resistance; Tauroursodeoxycholic acid; Nrf2; Bile
   salt hydrolase
ID INDUCED APOPTOSIS; RESISTANCE; MECHANISMS; CELLS; LIVER; NRF2
AB Metformin is widely used to surmount insulin resistance (IR) and type 2 diabetes. Accumulating evidence sug-gests that metformin may improve IR through regulating gut microbiota and bile acids. However, the underlying mechanisms remain unclear. Our metabolomic analysis showed that metformin significantly increased the accumulation of tauroursodeoxycholic acid (TUDCA) in intestine and liver from high-fat diet (HFD)-induced IR mice. TUDCA also alleviated IR, and reduced oxidative stress and intestinal inflammation in ob/ob mice. TUDCA blocked KEAP1 to bind with Nrf2, resulting in Nrf2 translocation into nuclear and initiating the transcription of antioxidant genes, which eventually reduced intracellular ROS accumulation and improved insulin signaling. Analysis of gut microbiota further revealed that metformin reduced the relative abundance of Bifidobacterium, which produces bile salt hydrolase (BSH). The reduction in BSH was probably crucial for the accumulation of TUDCA. Metformin also increased the proportion of Akkermanisia muciniphlia in gut microbiota of ob/ob mice via TUDCA. These beneficial effects of metformin in remodeling gut microbiota, reducing oxidative stress and improving insulin sensitivity were partly due to the accumulation of TUDCA, suggesting that TUDCA may be a potential therapy for metabolic syndrome.
C1 [Zhang, Ya; Cheng, Yang; Liu, Jian; Zuo, Jihui; Yan, Liping; Thring, Ronald W.; Wu, Mingjiang; Gao, Yitian; Tong, Haibin] Wenzhou Univ, Coll Life & Environm Sci, Zhejiang Prov Key Lab Water Environm & Marine Biol, Wenzhou, Peoples R China.
   [Zhang, Ya] Wenzhou Med Univ, Sch Lab Med & Life Sci, Key Lab Med Genet, Wenzhou, Peoples R China.
   [Ba, Xueqing] Northeast Normal Univ, Minist Educ, Key Lab Mol Epigenet, Changchun, Jilin, Peoples R China.
   [Qi, Dake] Univ Manitoba, Coll Pharm, Winnipeg, MB, Canada.
C3 Wenzhou University; Wenzhou Medical University; Ministry of Education -
   China; Northeast Normal University - China; University of Manitoba
RP Gao, YT; Tong, HB (corresponding author), Wenzhou Univ, Coll Life & Environm Sci, Zhejiang Prov Key Lab Water Environm & Marine Biol, Wenzhou, Peoples R China.
EM gyt@wzu.edu.cn; tonghaibin@gmail.com
RI Wu, MJ/KQV-3644-2024; zhang, ya/KJL-6126-2024
OI Thring, Ronald/0000-0003-2531-0235; Tong, Haibin/0000-0002-7645-3458
FU National Natural Science Foundation of China; Science and Technology
   Program of Wenzhou;  [81872952];  [41876197];  [ZY2019013]
FX Acknowledgements We gratefully thank Qiaojuan Li and Lingfeng Hou
   (Wenzhou Uni-versity) for their assistance in animal experiments. We
   gratefully thank Alan K Chang (Wenzhou University) for helpful
   discussion and for revising the language of the manuscript. We
   gratefully thank Jingling Shen (Wenzhou University) and Weitao Cong
   (Wenzhou Medical Uni-versity) for helpful discussion for revising the
   manuscript.
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NR 47
TC 24
Z9 27
U1 5
U2 44
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2213-2317
J9 REDOX BIOL
JI Redox Biol.
PD NOV
PY 2022
VL 57
AR 102481
DI 10.1016/j.redox.2022.102481
EA SEP 2022
PG 14
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 5A0KW
UT WOS:000862586600002
PM 36148770
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Merlo, E
   Schereider, IRG
   Simoes, MR
   Vassallo, DV
   Graceli, JB
AF Merlo, Eduardo
   Schereider, Ingridy R. G.
   Simoes, Maylla R.
   Vassallo, Dalton V.
   Graceli, Jones B.
TI Mercury leads to features of polycystic ovary syndrome in rats
SO TOXICOLOGY LETTERS
LA English
DT Article
DE Mercury; Endocrine disruptor chemical; Reproduction; Metabolism;
   Polycystic ovary syndrome
ID ENDOCRINE-DISRUPTING CHEMICALS; TRIBUTYLTIN CHLORIDE LEADS; METABOLIC
   SYNDROME; OXIDATIVE STRESS; BLOOD MERCURY; HEAVY-METALS;
   GLUCOSE-INTOLERANCE; DIAGNOSTIC-CRITERIA; MEDICAL PROGRESS; EXPOSURE
AB Mercury (Hg) is a heavy metal and Hg exposure is associated with various neural, immune, and cardiovascular abnormalities. However, few studies have evaluated Hg's toxicologic effect on reproductive and metabolic functions. In this study, we assessed whether Hg exposure results in reproductive and metabolic abnormalities. Hg was administered to adult female Wistar rats, mimicking the Hg levels found in exposed human blood, and their reproductive and metabolic function was assessed. Rats exposed to Hg displayed abnormal estrous cyclicity and ovarian follicular development, with a reduction in ovarian antral follicles and an increase in atretic and cystic ovarian follicles. Uterine atrophy with the presence of inflammatory cells was observed in Hg-exposed rats. The presence of abnormal ovarian fat accumulation, as well as increased ovarian lipid drops accumulation, was observed in Hg-exposed rats. Ovarian oxidative stress was also present in the Hg-exposed rats. High fasting glucose levels, glucose, and insulin intolerance were observed in Hg-exposed rats. Thus, these data suggest that Hg exposure led to abnormal reproductive and metabolic features similar to those found in the polycystic ovary syndrome (PCOS) rat models.
C1 [Merlo, Eduardo; Graceli, Jones B.] Univ Fed Espirito Santo, Dept Morphol, Vitoria, ES, Brazil.
   [Schereider, Ingridy R. G.; Simoes, Maylla R.; Vassallo, Dalton V.] Univ Fed Espirito Santo, Dept Physiol, Vitoria, ES, Brazil.
C3 Universidade Federal do Espirito Santo; Universidade Federal do Espirito
   Santo
RP Graceli, JB (corresponding author), Univ Fed Espirito Santo, Dept Morfol, CCS, Lab Endocrinol & Toxicol Celular, Av Marechal Campos 1468,Predio Basico 1,Sala 5, BR-29044009 Vitoria, ES, Brazil.
EM jbgraceli@gmail.com
RI Bernardes Graceli, Jones/ABC-7439-2021
OI Merlo, Eduardo/0000-0003-0155-1472; Schereider,
   Ingridy/0000-0002-6379-4050
FU FAPES [179/2017, 03/2017-UNIVERSAL]; CNPq [304724/2017-3, 12/2017];
   FAPES/CNPq (PRONEX) [24/2018, 572/2018]; Coordenacao de Aperfeicoamento
   de Pessoal de Nivel Superior - Brasil (CAPES) [00]; FAPES; CNPq
FX This research was supported by FAPES No 03/2017-UNIVERSAL (#179/2017),
   CNPq (#304724/2017-3/No 12/2017), FAPES/CNPq (PRONEX No 24/2018,
   #572/2018). JBG awarded grants by FAPES and CNPq. This study was
   financed in part by the Coordenacao de Aperfeicoamento de Pessoal de
   Nivel Superior - Brasil (CAPES)-Finance Code 00. Dr Sally Radovick for
   the critical review of the manuscript.
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NR 82
TC 33
Z9 33
U1 0
U2 48
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0378-4274
EI 1879-3169
J9 TOXICOL LETT
JI Toxicol. Lett.
PD SEP 15
PY 2019
VL 312
BP 45
EP 54
DI 10.1016/j.toxlet.2019.05.006
PG 10
WC Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Toxicology
GA IC8MA
UT WOS:000471234200005
PM 31071422
OA hybrid
DA 2025-06-11
ER

PT J
AU Guddeti, RR
   Dang, G
   Williams, MA
   Alla, VM
AF Guddeti, Raviteja R.
   Dang, Geetanjali
   Williams, Mark A.
   Alla, Venkata Mahesh
TI Role of Yoga in Cardiac Disease and Rehabilitation
SO JOURNAL OF CARDIOPULMONARY REHABILITATION AND PREVENTION
LA English
DT Review
DE arrhythmias; autonomic dysfunction; cardiac rehabilitation; heart
   failure
ID CARDIOVASCULAR-DISEASE; RISK-FACTORS; TRANSCRIPTOME DYNAMICS; METABOLIC
   SYNDROME; SMOKING-CESSATION; STRESS REDUCTION; CONTROLLED-TRIAL;
   BLOOD-PRESSURE; OLDER-ADULTS; HEART-RATE
AB Purpose: Cardiovascular disease continues to be the leading cause of morbidity and mortality around the world. Yoga, a combination of physical postures (asana), breathing exercises (pranayama), and meditation (dhyana), has gained increasing recognition as a form of mind-body exercise. In this narrative review, we intended to review the emerging evidence assessing the physiologic and clinical effects of yoga on the cardiovascular system and the potential role of yoga as a component of comprehensive cardiac rehabilitation.
   Methods: We searched PubMed, Google Scholar, Embase, and Cochrane databases for literature related to cardiovascular effects of yoga from inception up until 2017.
   Results: Yoga has been shown to have favorable effects on systemic inflammation, stress, the cardiac autonomic nervous system, and traditional and emerging cardiovascular risk factors.
   Conclusions: Yoga has shown promise as a useful lifestyle intervention that can be incorporated into cardiovascular disease management algorithms. Although many investigators have reported the clinical benefits of yoga in reducing cardiovascular events, morbidity, and mortality, evidence supporting these conclusions is somewhat limited, thereby emphasizing the need for large, well-designed randomized trials that minimize bias and methodological drawbacks.
C1 [Guddeti, Raviteja R.; Dang, Geetanjali; Williams, Mark A.; Alla, Venkata Mahesh] Creighton Univ, Sch Med, Div Cardiovasc Dis, Omaha, NE 68178 USA.
C3 Creighton University
RP Guddeti, RR (corresponding author), Creighton Univ, Sch Med, Div Cardiovasc Dis, Omaha, NE 68178 USA.
EM ravitejaguddeti@creighton.edu
RI Williams, Mark/J-5347-2013
OI Guddeti, Raviteja/0000-0001-8740-2501
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TC 27
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U1 0
U2 24
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1932-7501
EI 1932-751X
J9 J CARDIOPULM REHABIL
JI J. Cardiopulm. Rehabil. Prev.
PD MAY
PY 2019
VL 39
IS 3
BP 146
EP 152
DI 10.1097/HCR.0000000000000372
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Cardiovascular System & Cardiology
GA HX1PN
UT WOS:000467165600008
PM 31021995
DA 2025-06-11
ER

PT J
AU Kusminski, CM
   Holland, WL
   Sun, K
   Park, J
   Spurgin, SB
   Lin, Y
   Askew, GR
   Simcox, JA
   McClain, DA
   Li, C
   Scherer, PE
AF Kusminski, Christine M.
   Holland, William L.
   Sun, Kai
   Park, Jiyoung
   Spurgin, Stephen B.
   Lin, Ying
   Askew, G. Roger
   Simcox, Judith A.
   McClain, Don A.
   Li, Cai
   Scherer, Philipp E.
TI MitoNEET-driven alterations in adipocyte mitochondrial activity reveal a
   crucial adaptive process that preserves insulin sensitivity in obesity
SO NATURE MEDICINE
LA English
DT Article
ID HUMAN SKELETAL-MUSCLE; OXIDATIVE STRESS; ADIPOSE-TISSUE; MEMBRANE
   PROTEIN; METABOLIC SYNDROME; GENE-EXPRESSION; RESISTANCE; ADIPONECTIN;
   DYSFUNCTION; MECHANISMS
AB We examined mouse models with altered adipocyte expression of mitoNEET, a protein residing in the mitochondrial outer membrane, to probe its impact on mitochondrial function and subsequent cellular responses. We found that overexpression of mitoNEET enhances lipid uptake and storage, leading to an expansion of the mass of adipose tissue. Despite the resulting massive obesity, benign aspects of adipose tissue expansion prevail, and insulin sensitivity is preserved. Mechanistically, we also found that mitoNEET inhibits mitochondrial iron transport into the matrix and, because iron is a rate-limiting component for electron transport, lowers the rate of beta-oxidation. This effect is associated with a lower mitochondrial membrane potential and lower levels of reactive oxygen species-induced damage, along with increased production of adiponectin. Conversely, a reduction in mitoNEET expression enhances mitochondrial respiratory capacity through enhanced iron content in the matrix, ultimately corresponding to less weight gain on a high-fat diet. However, this reduction in mitoNEET expression also causes heightened oxidative stress and glucose intolerance. Thus, manipulation of mitochondrial function by varying mitoNEET expression markedly affects the dynamics of cellular and whole-body lipid homeostasis.
C1 [Kusminski, Christine M.; Holland, William L.; Sun, Kai; Park, Jiyoung; Spurgin, Stephen B.; Scherer, Philipp E.] Univ Texas SW Med Ctr Dallas, Dept Internal Med, Touchstone Diabet Ctr, Dallas, TX 75390 USA.
   [Lin, Ying] Albert Einstein Coll Med, Dept Cell Biol, Bronx, NY 10467 USA.
   [Askew, G. Roger; Li, Cai] Merck Res Labs, Dept Metab Disorders, Rahway, NJ USA.
   [Simcox, Judith A.; McClain, Don A.] Univ Utah, Sch Med, Dept Med & Biochem, Salt Lake City, UT USA.
   [McClain, Don A.] Virginia Med Ctr, Res Serv, Salt Lake City, UT USA.
   [Scherer, Philipp E.] Univ Texas SW Med Ctr Dallas, Dept Cell Biol, Dallas, TX 75390 USA.
C3 University of Texas System; University of Texas Southwestern Medical
   Center Dallas; Montefiore Medical Center; Albert Einstein College of
   Medicine; Yeshiva University; Merck & Company; Utah System of Higher
   Education; University of Utah; University of Texas System; University of
   Texas Southwestern Medical Center Dallas
RP Scherer, PE (corresponding author), Univ Texas SW Med Ctr Dallas, Dept Internal Med, Touchstone Diabet Ctr, Dallas, TX 75390 USA.
EM philipp.scherer@utsouthwestern.edu
RI Scherer, Philipp/K-7819-2012; park, Jiyoung/G-4592-2013
OI McClain, Don/0000-0002-3310-2359; Simcox, Judith/0000-0001-7350-6342;
   Sun, Kai/0000-0002-4778-4549; Spurgin, Stephen/0000-0003-0615-7626
FU US National Institutes of Health [R01-DK55758, RC1-DK086629,
   P01-DK088761, K99-DK094973]; American Heart Association [12BGIA8910006,
   R01-DK081842, T32-DK091317]; Department of Defense [USAMRMC-BC085909];
   Juvenile Diabetes Foundation [JDRF 3-2008-130]; American Heart
   Association (AHA) [12BGIA8910006] Funding Source: American Heart
   Association (AHA)
FX We thank P. D. Neufer, G. Schatz and C. B. Newgard for helpful comments
   and suggestions. We also thank J. Song and J. Xia for technical
   assistance, in addition to the rest of the Scherer laboratory, R. Unger
   and D. Clegg for helpful discussions. We also thank P. Blanchard and Y.
   Deshaies for kindly providing LPL activity measurements, R. Hammer and
   the University of Texas Southwestern (UTSW) Transgenic Core Facility for
   the generation of mouse models, as well as the UTSW Metabolic Core
   Facility for help in the phenotypic characterization of the mice and G.
   Milne from Vanderbilt University Medical Center for the F2-isoprostane
   analysis. The authors were supported by US National Institutes of Health
   grants R01-DK55758, RC1-DK086629 and P01-DK088761 (P. E. S.),
   K99-DK094973 and an American Heart Association Beginning Grant in Aid
   12BGIA8910006 (W. L. H.), R01-DK081842 (D. A. M.), T32-DK091317 (J. A.
   S.) and Department of Defense Fellowship USAMRMC-BC085909 (J. P.). C. M.
   K. was supported by a fellowship from the Juvenile Diabetes Foundation
   (JDRF 3-2008-130).
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NR 57
TC 374
Z9 410
U1 2
U2 66
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 1078-8956
J9 NAT MED
JI Nat. Med.
PD OCT
PY 2012
VL 18
IS 10
BP 1539
EP U144
DI 10.1038/nm.2899
PG 13
WC Biochemistry & Molecular Biology; Cell Biology; Medicine, Research &
   Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology; Research & Experimental
   Medicine
GA 017JZ
UT WOS:000309587500033
PM 22961109
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Dollard, J
   Kearney, P
   Clarke, G
   Moloney, G
   Cryan, JF
   Dinan, TG
AF Dollard, James
   Kearney, Peter
   Clarke, Gerard
   Moloney, Gerard
   Cryan, John F.
   Dinan, Timothy G.
TI A prospective study of C-reactive protein as a state marker in Cardiac
   Syndrome X
SO BRAIN BEHAVIOR AND IMMUNITY
LA English
DT Article
DE Angina pectoris; Inflammation; Normal coronary arteries; C-reactive
   protein; Microvascular angina; Stress
ID CORONARY-ARTERY-DISEASE; MICROVASCULAR DYSFUNCTION; CLINICAL
   PRESENTATION; CHEST-PAIN; INFLAMMATION; QUESTIONNAIRE; PERCEPTION
AB Cardiac Syndrome X (CSX), the presence of angina pectoris despite normal epicardial coronary arteries seen on invasive angiography, is known to be associated with an elevation of several inflammatory biomarkers, suggesting a possible role for inflammation in its pathogenesis. We sought to establish if C-reactive protein (CRP) levels varied with disease severity and so whether it is a state or trait marker. We studied 16 CSX patients with typical angina pectoris, normal coronary arteries and an electrically positive exercise stress test (EST) and 13 age- and sex-matched healthy controls (HC). CSX patients were followed up at a subsequent visit with repeated exercise stress testing and CRP measurement. We found that CRP levels were significantly higher in the CSX group compared to the HC (1.5 [0.8-4.5] v 0.8 [0.4-1.4] mg/L, p = 0.02). This elevation in CRP persisted throughout the study length. CRP correlated with time to symptoms on EST at enrolment and at the second visit (r = -0.690, df = 10, p = 0.013 and r = -0.899, df = 4, p = 0.015, respectively). At the follow-up visit, 50% of CSX patients developed electrically and symptomatically negative ESTs. The mean CRP of this group was significantly lower than that of the CSX patients with ongoing symptoms and positive ESTs (1.2 +/- 0.2 v 2.8 +/- 0.6 mg/ L, p = 0,018) and did not differ significantly from that of healthy controls. CRP levels also dropped in patients whose symptoms improved while they increased in patients who became more symptomatic (p = 0.027). We conclude that the results of this small study support the concept of CSX being an inflammatory-mediated condition with CRP levels prospectively varying with functional measures of disease severity. This indicates that CRP is a state marker in CSX. (C) 2014 Elsevier Inc. All rights reserved.
C1 [Dollard, James; Kearney, Peter] Cork Univ Hosp, Dept Cardiol, Cork, Ireland.
   [Clarke, Gerard; Dinan, Timothy G.] Natl Univ Ireland Univ Coll Cork, Dept Psychiat, Cork, Ireland.
   [Dollard, James; Clarke, Gerard; Moloney, Gerard; Cryan, John F.; Dinan, Timothy G.] Natl Univ Ireland Univ Coll Cork, Alimentary Pharmabiot Ctr, Cork, Ireland.
   [Moloney, Gerard; Cryan, John F.] Natl Univ Ireland Univ Coll Cork, Dept Anat & Neurosci, Cork, Ireland.
C3 University College Cork; University College Cork; University College
   Cork; University College Cork
RP Dinan, TG (corresponding author), Natl Univ Ireland Univ Coll Cork, Alimentary Pharmabiot Ctr, Cork, Ireland.
EM t.dinan@ucc.ie
RI Moloney, Gerard/AAI-8067-2020; Clarke, Gerard/Y-2551-2019; Dinan,
   Timothy/ABA-8284-2020; Cryan, John/A-6950-2013; Mc Kearney,
   Patrick/JNS-8730-2023
OI Dinan, Timothy/0000-0002-2316-7220; Cryan, John/0000-0001-5887-2723;
   Moloney, Gerard/0000-0002-3672-1390; Clarke, Gerard/0000-0001-9771-3979
FU Health Research Board; Irish government; Science Foundation Ireland
   [SFI/12/RC/2273]
FX JD is in receipt of an academic training fellowship award from the
   Health Research Board, an agency sponsored by the Irish government. The
   authors are supported, in part, by Science Foundation Ireland in the
   form of a centre grant (Alimentary Pharmabiotic Centre) under Grant
   Number SFI/12/RC/2273.
CR Arroyo-Espliguero R, 2006, CAN MED ASSOC J, V174, P1833, DOI 10.1503/cmaj.051331
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NR 20
TC 11
Z9 11
U1 0
U2 4
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0889-1591
EI 1090-2139
J9 BRAIN BEHAV IMMUN
JI Brain Behav. Immun.
PD JAN
PY 2015
VL 43
BP 27
EP 32
DI 10.1016/j.bbi.2014.07.011
PG 6
WC Immunology; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Neurosciences & Neurology; Psychiatry
GA CQ4RQ
UT WOS:000360592700005
PM 25064176
DA 2025-06-11
ER

PT J
AU Gutiérrez-Salmeán, G
   Ortiz-Vilchis, P
   Vacaseydel, CM
   Rubio-Gayosso, I
   Meaney, E
   Villarreal, F
   Ramírez-Sánchez, I
   Ceballos, G
AF Gutierrez-Salmean, Gabriela
   Ortiz-Vilchis, Pilar
   Vacaseydel, Claudia M.
   Rubio-Gayosso, Ivan
   Meaney, Eduardo
   Villarreal, Francisco
   Ramirez-Sanchez, Israel
   Ceballos, Guillermo
TI Acute effects of an oral supplement of (-)-epicatechin on postprandial
   fat and carbohydrate metabolism in normal and overweight subjects
SO FOOD & FUNCTION
LA English
DT Article
ID GLUCOSE-TOLERANCE; GREEN TEA; OXIDATION; POLYPHENOLS;
   EPIGALLOCATECHIN-3-GALLATE; RESISTANCE; EXENATIDE; INGESTION; CHOCOLATE;
   METFORMIN
AB Postprandial hyperglycemia, in particular when accompanied by excessive hypertriglyceridemia, is associated with increased cardiovascular risk, mainly in overweight or obese subjects, as it favors oxidative stress, systemic inflammation and endothelial dysfunction. Thus, treatments that favorably modulate metabolism by reducing steep increases in postprandial serum glucose and triglycerides, are of considerable interest. Evidence suggests that (-)-epicatechin (EPI) is responsible for reductions in cardiometabolic risk associated with chocolate consumption; these effects may be associated with favorable effects of EPI on postprandial metabolism. The aims of this study were to assess the effects of EPI on postprandial metabolism in normal-weight and overweight/obese subjects. Twenty adult volunteers (normal and overweight) underwent oral metabolic tolerance tests in the absence and presence of oral EPI (1 mg kg(-1)). Metabolic responses were examined using indirect calorimetry and determining blood glucose and triglycerides at 0, 2 and 4 hours after metabolic load ingestion. Results show that EPI increased postprandial lipid catabolism, as evidenced by a significant decrease in the respiratory quotient, which implies an increase in fat oxidation. The effect was associated with significantly lower postprandial plasma glucose and triglycerides concentrations. The effects were more prominent in overweight subjects. In conclusion, EPI modulates postprandial metabolism by enhancing lipid oxidation accompanied by reductions in glycemia and triglyceridemia.
C1 [Gutierrez-Salmean, Gabriela; Ortiz-Vilchis, Pilar; Vacaseydel, Claudia M.; Rubio-Gayosso, Ivan; Meaney, Eduardo; Ramirez-Sanchez, Israel; Ceballos, Guillermo] Inst Politecn Nacl, Escuela Super Med, Lab Invest Integral Cardiometab, Mexico City 11340, DF, Mexico.
   [Villarreal, Francisco] Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA.
C3 Instituto Politecnico Nacional - Mexico; University of California
   System; University of California San Diego
RP Gutiérrez-Salmeán, G (corresponding author), Inst Politecn Nacl, Escuela Super Med, Lab Invest Integral Cardiometab, Plan San Luis & Diaz Miron S-N, Mexico City 11340, DF, Mexico.
EM gceballosr@ipn.mx
RI Ceballos, Guillermo/A-7507-2013; Rubio-Gayosso, Ivan/L-9455-2017
OI Rubio-Gayosso, Ivan/0000-0001-8315-8572; Ortiz-Vilchis, Maria del
   Pilar/0000-0002-9780-4093; Ceballos, Guillermo/0000-0003-2155-3934
FU CONACYT Mexico [129889]; NIH [AT4277, P60MD001, HL43617, DK98717];
   Cardero Therapeutics; GGS CONACYT fellowship [304733]; Academy of
   Finland (AKA) [129889] Funding Source: Academy of Finland (AKA)
FX All authors declare that they do not have potential conflicts of
   interest. This work was supported by CONACYT Mexico grant # 129889 to GC
   and by NIH AT4277, P60MD001, HL43617 and DK98717 to FV, and by
   unrestricted gift from Cardero Therapeutics. GGS CONACYT fellowship #
   304733. GGS, IRS and GC designed research; GGS, MPOV and CMV conducted
   research; GC, EM and FV provided essential reagents and materials; GGS,
   EM, FV, IRS and GC analyzed data and performed statistical analysis;
   GGS, IRG, FV and IRS wrote the paper; GC, IRS, EM and FV were
   responsible for final comments.
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NR 31
TC 40
Z9 46
U1 1
U2 32
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PD MAR
PY 2014
VL 5
IS 3
BP 521
EP 527
DI 10.1039/c3fo60416k
PG 7
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA AD4MU
UT WOS:000333226000013
PM 24458104
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Remund, NP
   Larsen, JG
   Shin, MJ
   Warren, CE
   Palmer, IL
   Kim, IJ
   Cooper-Leavitt, ET
   Clarke, DM
   Beus, CG
   Johnson, RJ
   Arroyo, JA
   Reynolds, PR
   Bikman, BT
AF Remund, Nicole P.
   Larsen, John G.
   Shin, Marley J.
   Warren, Cali E.
   Palmer, Isabelle L.
   Kim, Iris J.
   Cooper-Leavitt, Elijah T.
   Clarke, Derek M.
   Beus, Colson G.
   Johnson, Richard J.
   Arroyo, Juan A.
   Reynolds, Paul R.
   Bikman, Benjamin T.
TI The Role of Beta-Hydroxybutyrate in Mitigating the Inflammatory and
   Metabolic Consequences of Uric Acid
SO METABOLITES
LA English
DT Article
DE uric acid; inflammation; ketones; insulin resistance; mitochondria
ID INSULIN-RESISTANCE; OXIDATIVE STRESS; HEPATIC STEATOSIS
AB Background: Uric acid (UA), a metabolite of purine and fructose metabolism, is linked to inflammation and metabolic disorders, including gout and cardiovascular disease. Its pro-inflammatory effects are largely driven by the activation of the nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome, leading to increased cytokine production. Beta-hydroxybutyrate (BHB), a ketone produced during fasting or carbohydrate restriction, has been shown to reduce inflammation. This study explores the role of BHB in mitigating the inflammatory and metabolic effects of elevated uric acid levels. Methods: We utilized a murine muscle cell culture treated with UA and BHB. Results: Muscle cells treated with UA had increased production of pro-inflammatory cytokines and reduced cell viability. Co-treatment with BHB reversed these effects, improving cell survival and reducing cytokine levels. Additionally, uric acid impaired mitochondrial function and increased oxidative stress, which were mitigated by BHB. Furthermore, uric acid disrupted insulin signaling, but BHB co-treatment restored insulin sensitivity. Conclusions: These findings suggest that BHB holds therapeutic potential by counteracting the inflammatory and metabolic disruptions caused by elevated uric acid, making it a promising target for conditions such as hyperuricemia and metabolic syndrome.
C1 [Remund, Nicole P.; Larsen, John G.; Shin, Marley J.; Warren, Cali E.; Palmer, Isabelle L.; Kim, Iris J.; Cooper-Leavitt, Elijah T.; Clarke, Derek M.; Beus, Colson G.; Arroyo, Juan A.; Reynolds, Paul R.; Bikman, Benjamin T.] Brigham Young Univ, Dept Cell Biol & Physiol, Provo, UT 84602 USA.
   [Johnson, Richard J.] Univ Colorado, Dept Med, Anschutz Med Campus, Aurora, CO 80045 USA.
C3 Brigham Young University; University of Colorado System; University of
   Colorado Anschutz Medical Campus
RP Bikman, BT (corresponding author), Brigham Young Univ, Dept Cell Biol & Physiol, Provo, UT 84602 USA.
EM bikman@byu.edu
RI Bikman, Benjamin/AAT-9606-2021
OI Reynolds, Paul/0000-0002-0931-3025
FU Anderson Active Ingredients;  [R0602714]
FX This research was funded by a Sponsored Research Award from Anderson
   Active Ingredients, grant number R0602714.
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NR 29
TC 3
Z9 3
U1 1
U2 1
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2218-1989
J9 METABOLITES
JI Metabolites
PD DEC
PY 2024
VL 14
IS 12
AR 679
DI 10.3390/metabo14120679
PG 9
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA Q4S8Q
UT WOS:001384607800001
PM 39728460
OA gold
DA 2025-06-11
ER

PT J
AU Swieca, M
   Regula, J
   Michalska, A
   Sierocka, M
   Jarocki, P
   Kordowska-Wiater, M
   Drzewiecka, B
   Kapusta, I
AF Swieca, Michal
   Regula, Julita
   Michalska, Agata
   Sierocka, Malgorzata
   Jarocki, Piotr
   Kordowska-Wiater, Monika
   Drzewiecka, Beata
   Kapusta, Ireneusz
TI Probiotic-rich bean sprouts alleviate oxidative stress and inflammation
   induced by a diet with an increased fat-to-carbohydrate energy ratio
SO INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
LA English
DT Article
DE Dietary intervention; high-fat diet; in vivo studies; legume; phenolics;
   probiotic; sprouts
ID INDUCED OBESITY; METABOLIC SYNDROME; IN-VITRO; ANTIOXIDANT; EXTRACT;
   PARAMETERS; LEGUMES; QUALITY; REDUCE
AB The rat's model evaluated the function of sprouted beans enriched with probiotic Lactiplantibacillus plantarum 299v in alleviating dyslipidaemia, inflammation and disturbed redox homeostasis caused by a high-lard diet. Sprouted beans improved the total antioxidant capacity of serum and liver, regardless of whether the feeds had a higher content of low-molecular antioxidants or were additionally enriched with probiotics. The reduction of inflammation (lowered level of C-reactive protein) and restoration of triglycerides and total cholesterol to the levels recorded in the control group (AIN-93M) were especially observed in the group supplemented with the control adzuki bean. Introducing sprouted legumes (both the control and probiotic-rich) improved microbiota activity affected by a high-lard diet. The highest, desirable reduction of urease (by 80%) and tryptophanase (by 78%) activity was found in the groups fed with probiotic-rich adzuki and mung bean sprouts respectively. Sprouted beans improve the metabolism of individuals subjected to a diet with an increased fat-to-carbohydrate energy ratio, especially concerning oxidative stress injury and microbiota activity.
C1 [Swieca, Michal; Michalska, Agata; Sierocka, Malgorzata] Univ Life Sci, Dept Biochem & Food Chem, Skromna Str 8, PL-20704 Lublin, Poland.
   [Regula, Julita] Poznan Univ Life Sci, Dept Human Nutr & Dietet, Wojska Polskiego Str 31, PL-60624 Poznan, Poland.
   [Jarocki, Piotr; Kordowska-Wiater, Monika] Univ Life Sci Lublin, Dept Biotechnol Microbiol & Human Nutr, Skromna Str 8, PL-20704 Lublin, Poland.
   [Drzewiecka, Beata] Univ Life Sci, Fac Vet Med, Sub Dept Pathophysiol, Dept Preclin Vet Sci, Akad 12, PL-20033 Lublin, Poland.
   [Kapusta, Ireneusz] Univ Rzeszow, Dept Food Technol & Human Nutr, Str Zelwerowicza 4, PL-35601 Rzeszow, Poland.
C3 Poznan University of Life Sciences; University of Life Sciences in
   Lublin; University of Rzeszow
RP Swieca, M (corresponding author), Univ Life Sci, Dept Biochem & Food Chem, Skromna Str 8, PL-20704 Lublin, Poland.
EM michal.swieca@up.lublin.pl
RI Kapusta, Ireneusz/AAJ-6458-2020; Drzewiecka, Beata/IUM-1355-2023;
   Regula, Julita/D-5823-2013; Sierocka, Małgorzata/JSK-9642-2023;
   Kordowska-Wiater, Monika/U-6338-2018; Swieca, Michal/B-4286-2014
OI Sierocka, Malgorzata/0000-0002-1761-3044; Swieca,
   Michal/0000-0002-6513-8399; Kapusta, Ireneusz/0000-0002-1197-2361;
   Michalska, Agata/0009-0001-0053-354X
FU National Science Centre, Poland (NCN) [2015/17/B/NZ9/01797]
FX This research was funded by the National Science Centre, Poland (NCN)
   (Grant OPUS No. 2015/17/B/NZ9/01797).
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NR 52
TC 1
Z9 1
U1 2
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0950-5423
EI 1365-2621
J9 INT J FOOD SCI TECH
JI Int. J. Food Sci. Technol.
PD OCT
PY 2024
VL 59
IS 10
BP 7263
EP 7275
DI 10.1111/ijfs.17452
EA AUG 2024
PG 13
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA K5O3P
UT WOS:001294062100001
OA Bronze
DA 2025-06-11
ER

PT J
AU Vieira-Souza, LM
   Aidar, FJ
   Nunes, PRP
   Costa, RD
   dos Santos, JL
   Getirana-Mota, M
   de Oliveira, DCX
   Brito, CJ
AF Vieira-Souza, Lucio Marques
   Aidar, Felipe J.
   Nunes, Paulo Ricardo Prado
   Costa, Roas de Araujo
   dos Santos, Jymmys Lopes
   Getirana-Mota, Marcio
   de Oliveira, Donizete Cicero Xavier
   Brito, Ciro Jose
TI EFFECTS OF HIGH-INTENSITY INTERVAL TRAINING ON ANTIOXIDANT CAPACITIES
SO RBONE-REVISTA BRASILEIRA DE OBESIDADE NUTRICAO E EMAGRECIMENTO
LA English
DT Article
DE HIIT; Antioxidant; Reactive Oxygen Species; Humans
ID OXIDATIVE STRESS; RISK-FACTORS; EXERCISE; OBESE; IMPROVES; ADAPTATIONS;
   INCREASES; RESPONSES; DISEASE; ADULTS
AB High-intensity interval training (HIIT) is currently one of the most used methods mainly for the treatment of cardiovascular diseases, metabolic syndrome and obesity. The present study aimed to carry out an integrative review on the effect of the HIIT method on antioxidant capacities in humans. The search terms used were HIIT with the following keywords and correlates: oxidative stress, lipid peroxidation, antioxidant capacity, antioxidant enzymes and free radicals. Inclusion criteria were HIIT intervention studies on antioxidant capacity, original articles and available in full in English, Spanish and Portuguese. Studies that did not meet these criteria were excluded. A total of 27 articles were found, of which only 7 met the selection criteria. Of these, 6 studies (85%) investigated the effect of HIIT on antioxidant capacity found beneficial results in these parameters. On the other hand, in one of included studies, the damage was repaired after exercise and one (15%) did not obtain statistically significant reductions. In this review, scientific evidence points to the effects resulting from antioxidant capacity and HIIT, however, it is necessary to carry out further studies to analyze this relationship, as it is not yet well described in literature.
C1 [Vieira-Souza, Lucio Marques; Nunes, Paulo Ricardo Prado] Univ Estado Minas Gerais, Human Movement Body Dept, Passos, MG, Brazil.
   [Vieira-Souza, Lucio Marques; Aidar, Felipe J.; Nunes, Paulo Ricardo Prado; Costa, Roas de Araujo; dos Santos, Jymmys Lopes; Getirana-Mota, Marcio; de Oliveira, Donizete Cicero Xavier; Brito, Ciro Jose] Ctr Studies & Res Phys Act Hlth & Sport, Passos, Brazil.
   [Vieira-Souza, Lucio Marques; Aidar, Felipe J.; dos Santos, Jymmys Lopes] Univ Fed Sergipe, Postgrad Program Phys Educ, Sao Cristovao, SE, Brazil.
   [Vieira-Souza, Lucio Marques; Brito, Ciro Jose] Univ Fed Juiz de Fora, Postgrad Program Phys Educ, Juiz De Fora, Brazil.
   [Aidar, Felipe J.; Getirana-Mota, Marcio] Univ Fed Sergipe, Postgrad Program Physiol Sci, Sao Cristovao, SE, Brazil.
C3 Universidade do Estado de Minas Gerais; Universidade Federal de Sergipe;
   Universidade Federal de Juiz de Fora; Universidade Federal de Sergipe
RP Vieira-Souza, LM (corresponding author), Univ Estado Minas Gerais, Human Movement Body Dept, Passos, MG, Brazil.; Vieira-Souza, LM (corresponding author), Ctr Studies & Res Phys Act Hlth & Sport, Passos, Brazil.; Vieira-Souza, LM (corresponding author), Univ Fed Sergipe, Postgrad Program Phys Educ, Sao Cristovao, SE, Brazil.; Vieira-Souza, LM (corresponding author), Univ Fed Juiz de Fora, Postgrad Program Phys Educ, Juiz De Fora, Brazil.
EM profedf.luciomarkes@gmail.com; fjaidar@gmail.com;
   paulo.pradonunes@gmail.com; roas.araujo@gmail.com;
   jymmyslopes@yahoo.com.br; marcio_getirana@hotmail.com;
   donizete.oliveira@uftm.edu.br; cirojbrito@gmail.com
RI Aidar, Felipe/L-7360-2019; Brito, Ciro/ABH-2245-2020; Oliveira,
   Donizete/AAI-9426-2021
CR Barauna VG, 2005, CLIN EXP PHARMACOL P, V32, P249, DOI 10.1111/j.1440-1681.2005.04180.x
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NR 42
TC 0
Z9 0
U1 0
U2 0
PU INST BRASILEIRO PESQUISA & ENSINO FISIOLOGIA EXERCICIO-IBPEFEX
PI SAO PAULO
PA INST BRASILEIRO PESQUISA & ENSINO FISIOLOGIA EXERCICIO-IBPEFEX, SAO
   PAULO, 00000, BRAZIL
SN 1981-9919
J9 RBONE-REV BRAS OBES
JI RBONE-Rev. Bras. Obes. Nutr. Emagrecimento
PD JUL-AUG
PY 2024
VL 18
IS 115
BP 784
EP 792
PG 9
WC Nutrition & Dietetics
WE Emerging Sources Citation Index (ESCI)
SC Nutrition & Dietetics
GA E4S4X
UT WOS:001302918000011
DA 2025-06-11
ER

PT J
AU Wang, ZY
   Cao, ZR
   Yue, ZY
   Yang, ZF
AF Wang, Ziyuan
   Cao, Zhuoran
   Yue, Zhiying
   Yang, Zhengfeng
TI Research progress of dihydromyricetin in the treatment of diabetes
   mellitus
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Review
DE dihydromyricetin; diabetes; diabetes complications; AMPK; research
   progress
ID ACTIVATED PROTEIN-KINASE; FATTY LIVER-DISEASE; SKELETAL-MUSCLE;
   OXIDATIVE STRESS; INSULIN-RESISTANCE; METABOLIC SYNDROME; AMPK; GLUCOSE;
   AUTOPHAGY; HYPERGLYCEMIA
AB Diabetic Mellitus (DM), a chronic metabolic disorder disease characterized by hyperglycemia, is mainly caused by the absolute or relative deficiency of insulin secretion or decreased insulin sensitivity in target tissue cells. Dihydromyricetin (DMY) is a flavonoid compound of dihydroflavonol that widely exists in Ampelopsis grossedentata. This review aims to summarize the research progress of DMY in the treatment of DM. A detailed summary of related signaling induced by DMY are discussed. Increasing evidence implicates that DMY display hypoglycemic effects in DM via improving glucose and lipid metabolism, attenuating inflammatory responses, and reducing oxidative stress, with the signal transduction pathways underlying the regulation of AMPK or mTOR/autophagy, and relevant downstream cascades, including PGC-1 & alpha;/SIRT3, MEK/ERK, and PI3K/Akt signal pathways. Hence, the mechanisms underlying the therapeutic implications of DMY in DM are still obscure. In this review, following with a brief introduction of the absorption, metabolism, distribution, and excretion characteristics of DMY, we summarized the current pharmacological developments of DMY as well as possible molecular mechanisms in the treatment of DM, aiming to push the understanding about the protective role of DMY as well as its preclinical assessment of novel application.
C1 [Wang, Ziyuan; Cao, Zhuoran; Yue, Zhiying; Yang, Zhengfeng] Shanghai Jiao Tong Univ, Shanghai Gen Hosp, Precis Res Ctr Refractory Dis, Sch Med, Shanghai, Peoples R China.
C3 Shanghai Jiao Tong University
RP Yang, ZF (corresponding author), Shanghai Jiao Tong Univ, Shanghai Gen Hosp, Precis Res Ctr Refractory Dis, Sch Med, Shanghai, Peoples R China.
EM zhengfeng.yang@shgh.cn
RI Wang, Ziyuan/KIC-5864-2024; Yang, Zhengfeng/AAA-7014-2020; Yue,
   Zhiying/JTV-1750-2023
FU National Natural Science Foundation of China [82003170, 82272645,
   81971555]; Shanghai Rising-Star Program [23QA1408100]; Natural Science
   Foundation of Shanghai [23ZR1451800]; Shanghai Municipal Health
   Commission [2022YQ065]
FX This work was supported by grants from the National Natural Science
   Foundation of China (82003170 to ZYY), the National Natural Science
   Foundation of China (82272645 & 81971555 to ZFY); The Shanghai
   Rising-Star Program (23QA1408100 to ZYY); the Natural Science Foundation
   of Shanghai (23ZR1451800 to ZYY); the Shanghai Municipal Health
   Commission (2022YQ065 to ZYY).
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NR 72
TC 11
Z9 13
U1 7
U2 33
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD SEP 4
PY 2023
VL 14
AR 1216907
DI 10.3389/fendo.2023.1216907
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA R8OY1
UT WOS:001066907000001
PM 37732125
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Song, P
   Hwang, JS
   Park, HC
   Kim, KK
   Son, HJ
   Kim, YJ
   Lee, KM
AF Song, Parkyong
   Hwang, Ji Sun
   Park, Hyean Cheal
   Kim, Keun Ki
   Son, Hong-Joo
   Kim, Yu-Jin
   Lee, Kwang Min
TI Therapeutic Applications of Type 2 Diabetes Mellitus Drug Metformin in
   Patients with Osteoarthritis
SO PHARMACEUTICALS
LA English
DT Review
DE osteoarthritis; type 2 diabetes mellitus; metformin; AMP-activated
   protein kinase
ID ACTIVATED PROTEIN-KINASE; GLYCATION END-PRODUCTS; KNEE OSTEOARTHRITIS;
   ARTICULAR-CARTILAGE; INSULIN-RESISTANCE; MITOCHONDRIAL DYSFUNCTION;
   SYNOVIAL INFLAMMATION; OXIDATIVE STRESS; GENE-EXPRESSION; BODY-WEIGHT
AB Type 2 diabetes mellitus (T2DM) and osteoarthritis (OA) are common chronic diseases that frequently co-exist. The link between OA and T2DM is attributed to common risk factors, including age and obesity. Several reports suggest that hyperglycemia and accumulated advanced glycosylation end-products might regulate cartilage homeostasis and contribute to the development and progression of OA. Metformin is used widely as the first-line treatment for T2DM. The drug acts by regulating glucose levels and improving insulin sensitivity. The anti-diabetic effects of metformin are mediated mainly via activation of adenosine monophosphate (AMP)-activated protein kinase (AMPK), which is an energy sensing enzyme activated directly by an increase in the AMP/ATP ratio under conditions of metabolic stress. Dysregulation of AMPK is strongly associated with development of T2DM and metabolic syndrome. In this review, we discuss common risk factors, the association between OA and T2DM, and the role of AMPK. We also address the adaptive use of metformin, a known AMPK activator, as a new drug for treatment of patients with OA and T2DM.
C1 [Song, Parkyong] Pusan Natl Univ, Dept Convergence Med, Sch Med, Yangsan 50612, South Korea.
   [Hwang, Ji Sun] Daegu Gyeongbuk Med Innovat Fdn, New Drug Dev Ctr, Daegu 41061, South Korea.
   [Park, Hyean Cheal; Kim, Keun Ki; Son, Hong-Joo; Kim, Yu-Jin; Lee, Kwang Min] Pusan Natl Univ, Dept Life Sci & Environm Biochem, Miryang 50463, South Korea.
   [Park, Hyean Cheal; Kim, Keun Ki; Son, Hong-Joo; Kim, Yu-Jin; Lee, Kwang Min] Pusan Natl Univ, Life & Ind Convergence Res Inst, Miryang 50463, South Korea.
C3 Pusan National University; Pusan National University; Pusan National
   University
RP Lee, KM (corresponding author), Pusan Natl Univ, Dept Life Sci & Environm Biochem, Miryang 50463, South Korea.; Lee, KM (corresponding author), Pusan Natl Univ, Life & Ind Convergence Res Inst, Miryang 50463, South Korea.
EM parkyong.song@pusan.ac.kr; hjs1228@dgmif.re.kr; hcpark@pusan.ac.kr;
   kkkim@pusan.ac.kr; shjoo@pusan.ac.kr; yjkim2020@pusan.ac.kr;
   leekm@pusan.ac.kr
OI Song, Parkyong/0000-0002-5004-3389
FU Pusan National University
FX This work was supported by a 2-Year Research Grant of Pusan National
   University.
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NR 145
TC 13
Z9 14
U1 0
U2 16
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1424-8247
J9 PHARMACEUTICALS-BASE
JI Pharmaceuticals
PD FEB
PY 2021
VL 14
IS 2
AR 152
DI 10.3390/ph14020152
PG 15
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA QO2GN
UT WOS:000622963400001
PM 33668426
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Ando, K
   Kawarazaki, H
   Miura, K
   Matsuura, H
   Watanabe, Y
   Yoshita, K
   Kawamura, M
   Kusaka, M
   Kai, H
   Tsuchihashi, T
   Kawano, Y
AF Ando, Katsuyuki
   Kawarazaki, Hiroo
   Miura, Katsuyuki
   Matsuura, Hideo
   Watanabe, Yoshihiko
   Yoshita, Katsushi
   Kawamura, Minoru
   Kusaka, Miho
   Kai, Hisashi
   Tsuchihashi, Takuya
   Kawano, Yuhei
TI Report of the Salt Reduction Committee of the Japanese Society of
   Hypertension (1) Role of salt in hypertension and cardiovascular
   diseases
SO HYPERTENSION RESEARCH
LA English
DT Review
DE blood pressure; heart disease; kidney disease; sodium chloride; stroke
ID DIETARY-SODIUM RESTRICTION; LEFT-VENTRICULAR MASS; BLOOD-PRESSURE;
   INSULIN SENSITIVITY; URINARY SODIUM; ANGIOTENSIN-II; ANTIPROTEINURIC
   EFFICACY; MYOCARDIAL-INFARCTION; OXIDATIVE STRESS; CIRCADIAN-RHYTHM
AB Dietary salt consumption is closely associated with the level of blood pressure (BP); stricter salt reduction more markedly decreased BP. Obesity/metabolic syndrome, Dietary Approach to Stop Hypertension (DASH) diet, exercise and mental stress influence the BP-elevating effect of high-salt diet. Observational and intervention studies suggested that salt restriction improved the risk of cardiovascular diseases. However, the effects may differ among the types of the hypertensive complications; salt reduction may decrease the risk of stroke more than that of ischemic heart disease. Small-scale studies demonstrated that excess salt increased the risk of the left ventricular hypertrophy, heart failure, the urinary protein/albumin levels and end-stage renal failure. These diverse beneficial effects of salt reduction are probably because low-salt diet is an effective strategy to decrease BP and body fluid volume but is less effective to ameliorate the other cardiovascular risk factors. A mean salt intake in Japan is markedly high. Considering the present condition, salt reduction is essential for the prevention and treatment of hypertension and for the prevention of cardiovascular diseases.
C1 [Ando, Katsuyuki] Univ Tokyo, Dept Nephrol & Endocrinol, Grad Sch Med, Tokyo 1138655, Japan.
   [Kawarazaki, Hiroo] St Marianna Univ, Dept Nephrol & Hypertens, Sch Med, Kawasaki, Kanagawa, Japan.
   [Miura, Katsuyuki] Shiga Univ Med Sci, Dept Hlth Sci, Otsu, Shiga 52021, Japan.
   [Matsuura, Hideo] Saiseikai Kure Hosp, Dept Internal Med, Kure, Japan.
   [Watanabe, Yoshihiko] Tokyo Womens Med Univ, Med Ctr East, Dept Med, Tokyo, Japan.
   [Yoshita, Katsushi] Osaka City Univ, Fac Human Life Sci, Sch Human Life Sci, Osaka 558, Japan.
   [Kawamura, Minoru] Iwate Cent Prefectural Hosp, Dept Gen Internal Med, Morioka, Iwate, Japan.
   [Kusaka, Miho] Kusaka Clin, Kure, Japan.
   [Kai, Hisashi] Kurume Univ, Sch Med, Div Cardiovasc Med, Dept Internal Med, Kurume, Fukuoka 830, Japan.
   [Tsuchihashi, Takuya] Natl Kyushu Med Ctr, Clin Res Inst, Div Hypertens, Fukuoka, Japan.
   [Kawano, Yuhei] Natl Cerebral & Cardiovasc Ctr, Div Hypertens & Nephrol, Suita, Osaka, Japan.
C3 University of Tokyo; Saint Marianna University; Shiga University of
   Medical Science; Tokyo Women's Medical University; Osaka Metropolitan
   University; Iwate Prefectural Central Hospital; Kurume University;
   National Cerebral & Cardiovascular Center - Japan
RP Ando, K (corresponding author), Univ Tokyo, Dept Nephrol & Endocrinol, Grad Sch Med, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1138655, Japan.
EM katsua-tky@umin.ac.jp
RI Kawano, Yuhei/AAM-2251-2020
OI Miura, Katsuyuki/0000-0002-2646-9582
FU Grants-in-Aid for Scientific Research [24591104] Funding Source: KAKEN
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NR 116
TC 29
Z9 29
U1 0
U2 20
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0916-9636
EI 1348-4214
J9 HYPERTENS RES
JI Hypertens. Res.
PD DEC
PY 2013
VL 36
IS 12
BP 1009
EP 1019
DI 10.1038/hr.2013.102
PG 11
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 269PL
UT WOS:000328253900001
PM 24152613
OA Bronze
DA 2025-06-11
ER

PT J
AU Önlü, H
   Teker, HT
   Keskin, S
   Genc, AI
   Allahverdi, H
   Elarslan, A
   Ceylani, T
AF Onlu, Harun
   Teker, Hikmet Taner
   Keskin, Seda
   Genc, Aysun Inan
   Allahverdi, Huseyin
   Elarslan, Aylin
   Ceylani, Taha
TI Role of the Probiotic Supplementation on Intestinal Inflammation and
   Structural Integrity in Wistar Rats Subjected to a Cafeteria Diet during
   Development
SO PAKISTAN VETERINARY JOURNAL
LA English
DT Article
DE Cafeteria diet; Development period; Inflammation; Intestinal tissue; SCD
   Probiotics; Wistar rat
ID GUT MICROBIOTA; METABOLIC SYNDROME; HEALTH; MODEL
AB Probiotics have gained significant interest in medical and veterinary sciences due to their potential to improve gastrointestinal health. This study investigates the protective role of probiotics on intestinal health in male Wistar rats exposed to a cafeteria diet during development. The experimental groups were divided into four: control, probiotics, cafeteria diet, and cafeteria diet with probiotics. Probiotics groups were administered daily at 1 x 108 CFU throughout the experiment. Ileum and colon tissues were analyzed via Fourier-transform infrared spectroscopy, histopathological analysis, and immunohistochemical staining. The cafeteria diet group showed altered lipid profiles, increased protein carbonylation (a marker of oxidative stress), and increased mast cell density, indicating increased intestinal inflammation. Probiotic supplementation significantly reduced inflammation by reducing TNF-alpha (P <= 0.0001) and IL-1(3 (P <= 0.0001). These results suggest that probiotic supplementation during an unhealthy diet can mitigate adverse effects by reducing oxidative stress and inflammation. Thus, probiotics could offer therapeutic potential in mitigating cafeteria diet-induced intestinal changes, serving as a promising dietary intervention during development to manage metabolic disorders in both humans and animals.
C1 [Onlu, Harun; Teker, Hikmet Taner; Ceylani, Taha] Mus Alparslan Univ, Dept Food Qual Control & Anal, Mus, Turkiye.
   [Onlu, Harun; Teker, Hikmet Taner; Allahverdi, Huseyin; Ceylani, Taha] Mus Alparslan Univ, Dept Mol Biol & Genet, Mus, Turkiye.
   [Teker, Hikmet Taner] Ankara Medipol Univ, Dept Med Biol & Genet, Ankara, Turkiye.
   [Keskin, Seda] Van Yuzuncu Yil Univ, Dept Histol & Embryol, Van, Turkiye.
   [Genc, Aysun Inan] Kastamonu Univ, Dept Biol, Kastamonu, Turkiye.
   [Elarslan, Aylin] Uludag Univ, Fac Vet Med, Dept Histol & Embryol, Uludag, Turkiye.
C3 Mus Alparslan University; Mus Alparslan University; Ankara Medipol
   University; Yuzuncu Yil University; Kastamonu University; Uludag
   University
RP Teker, HT; Ceylani, T (corresponding author), Mus Alparslan Univ, Dept Food Qual Control & Anal, Mus, Turkiye.; Teker, HT; Ceylani, T (corresponding author), Mus Alparslan Univ, Dept Mol Biol & Genet, Mus, Turkiye.; Teker, HT (corresponding author), Ankara Medipol Univ, Dept Med Biol & Genet, Ankara, Turkiye.
EM h.tanerteker@gmail.com; t.ceylani@alparslan.edu.tr
RI ONLU, Harun/HKE-0478-2023; İnan Genç, Aysun/KHW-8863-2024; Teker, Taner
   Hikmet/JKI-9155-2023; Keskin, Seda/A-4616-2019; Ceylani,
   Taha/HJH-8007-2023
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NR 44
TC 1
Z9 1
U1 2
U2 2
PU UNIV AGRICULTURE, FAC VETERINARY SCIENCE
PI FAISALABAD
PA UNIV AGRICULTURE, FAC VETERINARY SCIENCE, FAISALABAD, 00000, PAKISTAN
SN 0253-8318
EI 2074-7764
J9 PAK VET J
JI Pak. Vet. J.
PY 2025
VL 45
IS 1
BP 226
EP 235
DI 10.29261/pakvetj/2025.002
PG 10
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA 1OW3V
UT WOS:001470146300020
OA gold
DA 2025-06-11
ER

PT J
AU Zhang, WY
   Wang, MH
   Xie, C
AF Zhang, Wen-Yige
   Wang, Meng-Hui
   Xie, Chuan
TI Potential of traditional Chinese medicine in the treatment of
   nonalcoholic fatty liver disease: A promising future
SO WORLD JOURNAL OF GASTROENTEROLOGY
LA English
DT Article
DE Nonalcoholic fatty liver disease; Traditional Chinese medicine; High-fat
   diet; Potential; Prospects
ID OXIDATIVE STRESS; STEATOHEPATITIS
AB In this editorial, we provide insights into the publication by Niu et al featured in the latest edition of the World Journal of Gastroenterology. Specifically, our focus was on exploring the potential of traditional Chinese medicine (TCM) in treating nonalcoholic fatty liver disease (NAFLD) induced by a high-fat diet through various mechanisms. NAFLD is a common liver condition, affecting approximately 25% of the world's population. It is closely linked to metabolic syndrome, insulin resistance, excessive body weight, and irregular lipid processing, leading to fat accumulation in the liver, as well as oxidative stress and inflammation. While maintaining a healthy diet and active lifestyle are essential for managing NAFLD, treatment options are limited due to undefined pathogenesis and a lack of specific medications. TCM, rooted in traditional Chinese practices, presents a promising alternative through its "syndrome differentiation and treatment" principles, enhancing liver lipid metabolism, reducing inflammation, and addressing fibrosis. Certain herbs, such as Poria cocos, Puaria lobata, and Salvia miltiorrhiza, have shown significant efficacy in reducing fat deposition and improving liver function. Due to systematic research and analysis of mechanisms, TCM is anticipated to yield new approaches to prevent and treat NAFLD, increasing its clinical application.
C1 [Zhang, Wen-Yige; Wang, Meng-Hui; Xie, Chuan] Nanchang Univ, Digest Dis Hosp, Affiliated Hosp 1,Dept Gastroenterol,Jiangxi Prov, Jiangxi Med Coll,Jiangxi Clin Res Ctr Gastroenter, 17 Yongwaizheng St, Nanchang 330006, Jiangxi, Peoples R China.
   [Zhang, Wen-Yige] Nanchang Univ, Jiangxi Med Coll, Queen Mary Coll, Nanchang 330006, Jiangxi, Peoples R China.
C3 Nanchang University; Nanchang University
RP Xie, C (corresponding author), Nanchang Univ, Digest Dis Hosp, Affiliated Hosp 1,Dept Gastroenterol,Jiangxi Prov, Jiangxi Med Coll,Jiangxi Clin Res Ctr Gastroenter, 17 Yongwaizheng St, Nanchang 330006, Jiangxi, Peoples R China.
EM xcsghhz@ncu.edu.cn
RI XIE, CHUAN/ABC-6916-2020
FU National Natural Science Foundation of China [82100599, 81960112];
   Jiangxi Provincial Department of Science and Technology [20242BAB26122];
   Science and Technology Plan of Jiangxi Provincial Administration of
   Traditional Chinese Medicine [2023Z021]; Project of Jiangxi Provincial
   Academic and Technical Leaders Training Program for Major Disciplines
   [20243BCE51001]
FX Supported by National Natural Science Foundation of China, No. 82100599
   and No. 81960112; Jiangxi Provincial Department of Science and
   Technology, No. 20242BAB26122; Science and Technology Plan of Jiangxi
   Provincial Administration of Traditional Chinese Medicine, No. 2023Z021;
   and Project of Jiangxi Provincial Academic and Technical Leaders
   Training Program for Major Disciplines, No. 20243BCE51001.
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NR 29
TC 1
Z9 1
U1 6
U2 6
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 7041 Koll Center Parkway, Suite 160, PLEASANTON, CA, UNITED STATES
SN 1007-9327
EI 2219-2840
J9 WORLD J GASTROENTERO
JI World J. Gastroenterol.
PD NOV 21
PY 2024
VL 30
IS 43
DI 10.3748/wjg.v30.i43.4597
PG 6
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA M8T8Y
UT WOS:001360211000009
PM 39575403
DA 2025-06-11
ER

PT J
AU Izzo, C
   Annunziata, M
   Melara, G
   Sciorio, R
   Dallio, M
   Masarone, M
   Federico, A
   Persico, M
AF Izzo, Carmine
   Annunziata, Monica
   Melara, Giuseppe
   Sciorio, Roberta
   Dallio, Marcello
   Masarone, Mario
   Federico, Alessandro
   Persico, Marcello
TI The Role of Resveratrol in Liver Disease: A Comprehensive Review from In
   Vitro to Clinical Trials
SO NUTRIENTS
LA English
DT Review
DE resveratrol; non-alcoholic fatty liver disease; nutraceutical; oxidative
   stress
ID INDUCED OXIDATIVE STRESS; CELL-CYCLE ARREST; HEPATIC STELLATE CELLS;
   ALCOHOLIC FATTY LIVER; RED WINE POLYPHENOL; VIRUS X PROTEIN; NF-KAPPA-B;
   HEPATOCELLULAR-CARCINOMA; DOWN-REGULATION; MEDIATED CHEMOPREVENTION
AB Many studies have shown that resveratrol has a lot of therapeutic effects on liver disorders. Its administration can significantly increase the survival rate after liver transplantation, reduce fat deposition and ischemia-induced necrosis and apoptosis in Wistar rats. Resveratrol can provide Liver protection against chemical, cholestatic, and alcohol-mediated damage. It can improve glucose metabolism and lipid profile, reduce liver fibrosis, and steatosis. Additionally, it is capable of altering the fatty acid composition of the liver cells. Resveratrol may be a potential treatment option for the management of non-alcoholic fatty liver disease (NAFLD) due to its anti-inflammatory, antioxidant, and calorie-restricting effects. There are also studies that have evaluated the effect of resveratrol on lipid and liver enzyme profiles among patients with metabolic syndrome (MetS) and related disorders. Based on the extent of liver disease worldwide and the need to find new treatment possibilities, this review critically examines current in vitro and in vivo preclinical studies and human clinical studies related to liver protection.
C1 [Izzo, Carmine; Annunziata, Monica; Melara, Giuseppe; Sciorio, Roberta; Masarone, Mario; Persico, Marcello] Univ Salerno, Dept Med & Surg, Internal Med & Hepatol Div, Scuola Med Salernitana, I-84081 Salerno, Italy.
   [Izzo, Carmine; Annunziata, Monica; Melara, Giuseppe; Sciorio, Roberta; Masarone, Mario; Persico, Marcello] Univ Salerno, Dept Med Surg & Dent, Scuola Med Salernitana, I-84081 Salerno, Italy.
   [Dallio, Marcello; Federico, Alessandro] Univ Campania Luigi Vanvitelli, Dept Precis Med, Hepatogastroenterol Div, Via Pansini 5, I-80131 Naples, Italy.
C3 University of Salerno; University of Salerno; Universita della Campania
   Vanvitelli
RP Persico, M (corresponding author), Univ Salerno, Dept Med & Surg, Internal Med & Hepatol Div, Scuola Med Salernitana, I-84081 Salerno, Italy.; Persico, M (corresponding author), Univ Salerno, Dept Med Surg & Dent, Scuola Med Salernitana, I-84081 Salerno, Italy.
EM carmine.izzo93@gmail.com; annunziata.monica@gmail.com;
   gius.melara@gmail.com; robertasciorio92@gmail.com;
   marcello.dallio@gmail.com; mario.masarone@gmail.com;
   alessandro.federico@unicampania.it; mpersico@unisa.it
RI Dallio, Marcello/ABG-7693-2020; Federico, Alessandro/AAB-3893-2019;
   Izzo, Carmine/GQI-2627-2022; Masarone, Mario/H-8633-2017
OI Federico, Alessandro/0000-0002-0885-0793; Persico,
   Marcello/0000-0002-1399-6498; DALLIO, MARCELLO/0000-0003-4153-815X;
   Masarone, Mario/0000-0003-0550-8201; Izzo, Carmine/0000-0001-8499-5428
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NR 196
TC 75
Z9 80
U1 1
U2 42
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD MAR
PY 2021
VL 13
IS 3
AR 933
DI 10.3390/nu13030933
PG 23
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA RE1SJ
UT WOS:000633942800001
PM 33805795
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Sung, J
   Ho, CT
   Wang, Y
AF Sung, Jeehye
   Ho, Chi-Tang
   Wang, Yu
TI Preventive mechanism of bioactive dietary foods on obesity-related
   inflammation and diseases
SO FOOD & FUNCTION
LA English
DT Review
ID ENDOPLASMIC-RETICULUM STRESS; ADIPOSE-TISSUE MACROPHAGES; LOW-GRADE
   INFLAMMATION; NECROSIS-FACTOR-ALPHA; INSULIN-RESISTANCE; OXIDATIVE
   STRESS; METABOLIC SYNDROME; AMELIORATES HYPERGLYCEMIA;
   CARDIOVASCULAR-DISEASE; INHIBIT INFLAMMATION
AB Obesity is associated with low-grade chronic inflammation of adipose tissue, which leads to the development of metabolic disorders such as insulin resistance, type 2 diabetes, cardiovascular disease (CVD), and cancer. Obesity and a high calorie diet are associated with altered endocrine and metabolic functions of adipose tissue, contributing to systemic inflammation as a result of the release of pro-inflammatory cytokines/adipokines into the circulation and metabolic endotoxemia. Furthermore, the accumulation of proinflammatory macrophages within the visceral adipose tissue may also be a major cause of chronic inflammation of adipocytes. Thus, it is important to understand the factors that regulate the function of both adipocytes and macrophages to find attractive strategies against the burden of obesity-induced health problems. Although the vast range of activities of dietary bioactive compounds on obesity and inflammation have been widely investigated, the mechanisms underlying their beneficial effects on obesity-associated inflammatory response are still poorly understood. This review focuses on the molecular biology mechanism of obesity-induced inflammation and the reciprocal interactions between the major molecular mechanisms and a range of dietary bioactive compounds.
C1 [Sung, Jeehye; Wang, Yu] Univ Florida, Citrus Res & Educ Ctr, Food Sci & Human Nutr, 700 Expt Stn Rd, Lake Alfred, FL 33850 USA.
   [Ho, Chi-Tang] Rutgers State Univ, Dept Food Sci, 65 Dudley Rd, New Brunswick, NJ 08901 USA.
C3 State University System of Florida; University of Florida; Rutgers
   University System; Rutgers University New Brunswick
RP Wang, Y (corresponding author), Univ Florida, Citrus Res & Educ Ctr, Food Sci & Human Nutr, 700 Expt Stn Rd, Lake Alfred, FL 33850 USA.
EM yu.wang@ufl.edu
RI Ho, Chi-Tang/B-5629-2012
OI Ho, Chi-Tang/0000-0001-8273-2085
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NR 121
TC 41
Z9 46
U1 0
U2 34
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PD DEC 1
PY 2018
VL 9
IS 12
BP 6082
EP 6096
DI 10.1039/c8fo01561a
PG 15
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA HE3HP
UT WOS:000453244900002
PM 30403220
DA 2025-06-11
ER

PT J
AU Maia, DB
   Marmar, CR
   Mendlowicz, MV
   Metzler, T
   Nóbrega, A
   Peres, MC
   Coutinho, ES
   Volchan, E
   Figueira, I
AF Maia, Deborah Bezerra
   Marmar, Charles R.
   Mendlowicz, Mauro V.
   Metzler, Thomas
   Nobrega, Augusta
   Peres, Mhara C.
   Coutinho, Evandro S.
   Volchan, Eliane
   Figueira, Ivan
TI Abnormal serum lipid profile in Brazilian police officers with
   post-traumatic stress disorder
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE post-traumatic stress disorder; cholesterol; low-density lipoprotein;
   high-density lipoprotein; triglycerides
ID CHOLINESTERASE; VETERANS; VICTIMS
AB ,Background: To measure the serum lipid composition of a sample of Brazilian police officers with and without PTSD regularly exposed to potentially traumatic situations.
   Methods: A cross-sectional survey was conducted with 118 active duty male police officers. Serum concentrations for total cholesterol, LDL-C, HDL-C, and triglycerides were enzymatically determined. Body mass index (BMI) was obtained for each participant.
   Results: Officers with PTSD exhibited significantly higher serum total cholesterol, LDL-C and triglycerides levels than those without PTSD. Total cholesterol and triglycerides, but not LDL-C, remained associated with PTSD diagnosis after controlling for confounding influences (i.e. socio-demographics, BMI, and tobacco, alcohol and medication use).
   Limitations: The sample size was small. A nutritional interview was employed instead of established scales to assess alimentary habits, tobacco or alcohol consumption. A self-report screening tool was used to assess the prevalence of PTSD.
   Conclusions: The association between PTSD and abnormal serum lipid profile and a tendency to exhibit higher BMI suggests that individuals with PTSD may be at increased risk for developing metabolic syndrome, a condition that by itself could account for many of the most serious PTSD-related physical health problems. (C) 2007 Elsevier B.V. All rights reserved.
C1 [Maia, Deborah Bezerra; Mendlowicz, Mauro V.; Volchan, Eliane; Figueira, Ivan] Univ Fed Rio de Janeiro, Inst Psychiat, IPUB, Rio De Janeiro, Brazil.
   [Marmar, Charles R.; Metzler, Thomas] Univ Calif San Francisco, Dept Psychiat, San Francisco, CA 94143 USA.
   [Nobrega, Augusta; Peres, Mhara C.] Mil Police State Goias, Goiania, Go, Brazil.
   [Mendlowicz, Mauro V.] Univ Fed Fluminense, Dept Psychiat & Mental Hlth, Niteroi, RJ, Brazil.
   [Coutinho, Evandro S.] Fiocruz MS, ENSP, Natl Sch Publ Hlth, BR-21045900 Rio De Janeiro, Brazil.
C3 Universidade Federal do Rio de Janeiro; University of California System;
   University of California San Francisco; Universidade Federal Fluminense;
   Fundacao Oswaldo Cruz
RP Maia, DB (corresponding author), Univ Fed Rio de Janeiro, Inst Psychiat, IPUB, Rio De Janeiro, Brazil.
EM debmaia@terra.com.br
RI Coutinho, Evandro/E-2408-2011; Volchan, Eliane/C-5792-2013; figueira,
   ivan/B-4577-2008; Marmar, Charles/O-1902-2017
OI Coutinho, Evandro/0000-0002-4649-7353
FU NIMH NIH HHS [R01 MH056350, R01-MH56350-01A1] Funding Source: Medline
CR BERGER W, 2004, REV PSIQUIATR RIO GD, V26
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NR 9
TC 69
Z9 72
U1 0
U2 5
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0165-0327
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD APR
PY 2008
VL 107
IS 1-3
BP 259
EP 263
DI 10.1016/j.jad.2007.08.013
PG 5
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA 282CU
UT WOS:000254546000035
PM 17888517
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Chávez-Castillo, M
   Nuñez, V
   Rojas, M
   Ortega, A
   Durán, P
   Pirela, D
   Marquina, M
   Cano, C
   Chacín, M
   Velasco, M
   Rojas-Quintero, J
   Bermúdez, V
AF Chavez-Castillo, Mervin
   Nunez, Victoria
   Rojas, Milagros
   Ortega, Angel
   Duran, Pablo
   Pirela, Daniela
   Marquina, Maria
   Cano, Climaco
   Chacin, Maricarmen
   Velasco, Manuel
   Rojas-Quintero, Joselyn
   Bermudez, Valmore
TI Exploring Phytotherapeutic Alternatives for Obesity, Insulin Resistance
   and Diabetes Mellitus
SO CURRENT PHARMACEUTICAL DESIGN
LA English
DT Review
DE Phytotherapy; medicinal herbs; obesity; insulin resistance; diabetes
   mellitus; cardiovascular disease
ID RANDOMIZED DOUBLE-BLIND; CHINESE HERBAL MEDICINE; IMPAIRED
   GLUCOSE-TOLERANCE; ACTIVATED PROTEIN-KINASE; GLYCEMIC CONTROL; LIPID
   PROFILE; GREEN TEA; METABOLIC SYNDROME; OXIDATIVE STRESS; BLOOD-GLUCOSE
AB At present, the pathologic spectrum of obesity-insulin resistance (IR)-diabetes mellitus (DM) represents not only a pressing matter in public health but also a paramount object of study in biomedical research, as they constitute major risk factors for cardiovascular disease (CVD), and other chronic non-communicable diseases (NCD). Phytotherapy, the use of medicinal herbs (MH) with treatment purposes, offers a wide array of opportunities for innovation in the management of these disorders; mainly as pharmacological research on small molecules accumulates. Several MH has displayed varied mechanisms of action relevant to the pathogenesis of obesity, IR and DM, including immunological and endocrine modulation, reduction of inflammation and oxidative stress (OS), regulation of appetite, thermogenesis and energy homeostasis, sensitisation to insulin function and potentiation of insulin release, among many others. However, the clinical correlates of these molecular phenomena remain relatively uncertain, with only a handful of MH boasting convincing clinical evidence in this regard. This review comprises an exploration of currently available preclinical and clinical research on the role of MH in the management of obesity, IR, and DM.
C1 [Chavez-Castillo, Mervin] Psychiat Hosp Maracaibo, Maracaibo, Venezuela.
   [Chavez-Castillo, Mervin; Nunez, Victoria; Rojas, Milagros; Ortega, Angel; Duran, Pablo; Pirela, Daniela; Marquina, Maria; Cano, Climaco] Univ Zulia, Endocrine & Metab Dis Res Ctr, Sch Med, 20th Ave, Maracaibo 4004, Venezuela.
   [Chacin, Maricarmen; Bermudez, Valmore] Univ Simon Bolivar, Fac Ciencias Salud, Barranquilla, Colombia.
   [Velasco, Manuel] Cent Univ Venezuela, Jose Maria Vargas Sch Med, Clin Pharmacol Unit, Caracas, Venezuela.
   [Rojas-Quintero, Joselyn] Harvard Med Sch, Brigham & Womens Hosp, Pulm & Crit Care Med Dept, Boston, MA 02115 USA.
C3 University of Central Venezuela; Harvard University; Harvard Medical
   School; Harvard University Medical Affiliates; Brigham & Women's
   Hospital
RP Chávez-Castillo, M (corresponding author), Univ Zulia, Endocrine & Metab Dis Res Ctr, Sch Med, 20th Ave, Maracaibo 4004, Venezuela.
EM mervinch@hotmail.com
RI Duran, Pablo/AAW-6866-2020; Ortega, Angel/JAO-1213-2023; Bermudez,
   Valmore/E-3517-2018
OI Chacin, Maricarmen/0000-0002-5208-9401; Pirela Colina, Daniela
   Andreina/0000-0002-7208-1415; Bermudez, Valmore/0000-0003-1880-8887;
   Rojas, Milagros/0000-0003-2764-8846; Chavez, Mervin/0000-0001-8511-0230;
   Ortega-Martinez, Angel/0000-0002-7180-4765; Marquina Stagg, Maria
   Angelica/0000-0002-6203-181X; Duran, Pablo/0000-0002-8030-1780;
   Rojas-Quintero, Joselyn Joanna/0000-0003-4994-075X
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NR 219
TC 4
Z9 4
U1 0
U2 21
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1381-6128
EI 1873-4286
J9 CURR PHARM DESIGN
JI Curr. Pharm. Design
PY 2020
VL 26
IS 35
BP 4430
EP 4443
DI 10.2174/1381612826666200701205132
PG 14
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA OH3WJ
UT WOS:000582502300007
PM 32611293
DA 2025-06-11
ER

PT J
AU Ugochukwu, NH
   Figgers, CL
AF Ugochukwu, Ngozi H.
   Figgers, Cynthia L.
TI Caloric restriction inhibits up-regulation of inflammatory cytokines and
   TNF-α, and activates IL-10 and haptoglobin in the plasma of
   streptozotocin-induced diabetic rats
SO JOURNAL OF NUTRITIONAL BIOCHEMISTRY
LA English
DT Article
DE inflammation; diabetes; caloric restriction; interleukins; TNF-alpha;
   haptoglobin
ID NECROSIS-FACTOR-ALPHA; C-REACTIVE PROTEIN; CORONARY-ARTERY-DISEASE;
   METABOLIC SYNDROME; INTERLEUKIN-6; RESISTANCE; RESPONSES; OBESITY; RISK;
   MECHANISMS
AB Diabetes mellitus is a significant risk factor for cardiovascular diseases, and low-grade systemic inflammation, mediated by oxidative stress, may play a central role. Caloric restriction (CR) has been reported to be effective in reducing oxidative stress during diabetes and moderating the expression of some markers of inflammation that are up-regulated during aging. Forty male Wistar rats were randomly divided into four groups: nondiabetic feeding ad libitum and under CR, and diabetic feeding ad libitum and under CR. The animals were subjected to 30% CR and ad libitum feeding for 9 weeks before the induction of diabetes by intraperitoneal injection with 35 mg/kg body weight streptozotocin. The inflammatory cytokines [interleukin (IL)-1 beta, IL-4 and IL-6] and tumor necrosis factor alpha up-regulated in diabetes were found to be significantly depressed by CR, whereas the antiinflammatory mediators, haptoglobin and IL-10 levels, were increased. These results indicated that CR could prevent diabetic complications through suppression of inflammatory responses. (c) 2007 Elsevier Inc. All rights reserved.
C1 Florida A&M Univ, Dept Chem, Tallahassee, FL 32307 USA.
C3 State University System of Florida; Florida A&M University; Florida
   State University
RP Ugochukwu, NH (corresponding author), Florida A&M Univ, Dept Chem, Tallahassee, FL 32307 USA.
EM ngozi.ugochukwu@famu.edu
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NR 50
TC 49
Z9 53
U1 1
U2 5
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0955-2863
EI 1873-4847
J9 J NUTR BIOCHEM
JI J. Nutr. Biochem.
PD FEB
PY 2007
VL 18
IS 2
BP 120
EP 126
DI 10.1016/j.jnutbio.2006.03.008
PG 7
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA 129XL
UT WOS:000243763300006
PM 16713232
DA 2025-06-11
ER

PT J
AU Catana, OM
   Nemes, AF
   Cioboata, R
   Toma, CL
   Mitroi, DM
   Calarasu, C
   Streba, CT
AF Catana, Oana Maria
   Nemes, Alexandra Floriana
   Cioboata, Ramona
   Toma, Claudia Lucia
   Mitroi, Denisa Maria
   Calarasu, Cristina
   Streba, Costin Teodor
TI Leptin and Insulin in COPD: Unveiling the Metabolic-Inflammatory Axis-A
   Narrative Review
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Review
DE chronic obstructive pulmonary disease; COPD; leptin; insulin;
   metabolic-inflammatory axis; oxidative stress
ID OBSTRUCTIVE-PULMONARY-DISEASE; SELF-MANAGEMENT INTERVENTIONS;
   HYPOTHALAMIC ARCUATE NUCLEUS; VASTUS LATERALIS MUSCLE; RECEPTOR
   MESSENGER-RNA; NF-KAPPA-B; OXIDATIVE STRESS; BODY-COMPOSITION; SERUM
   LEPTIN; GLUCOSE-HOMEOSTASIS
AB Chronic obstructive pulmonary disease (COPD) is a progressive and debilitating condition characterized by airflow limitations and systemic inflammation. The interaction between the metabolic and inflammatory pathways plays a key role in disease progression, with leptin and insulin emerging as pivotal metabolic regulators. Leptin, an adipokine that regulates energy homeostasis, and insulin, the primary regulator of glucose metabolism, are both altered in COPD patients. This narrative review provides an in-depth examination of the roles of leptin and insulin in COPD pathogenesis, focusing on the molecular mechanisms through which these metabolic regulators interact with inflammatory pathways and how their dysregulation contributes to a spectrum of extrapulmonary manifestations. These disturbances not only exacerbate COPD symptoms but also increase the risk of comorbidities such as metabolic syndrome, diabetes, cardiovascular disease, or muscle wasting. By exploring the underlying mechanisms of leptin and insulin dysregulation in COPD, this review underscores the significance of the metabolic-inflammatory axis, suggesting that restoring metabolic balance through leptin and insulin modulation could offer novel therapeutic strategies for improving clinical outcomes.
C1 [Catana, Oana Maria; Mitroi, Denisa Maria] Univ Med & Pharm, Doctoral Sch, Craiova 200349, Romania.
   [Nemes, Alexandra Floriana] Mem Life Hosp Bucharest, Neonatol Dept, Bucharest 010719, Romania.
   [Cioboata, Ramona; Calarasu, Cristina; Streba, Costin Teodor] Univ Med & Pharm, Pneumol Dept, Craiova 200349, Romania.
   [Toma, Claudia Lucia] Univ Med & Pharm Carol Davila, Pneumol Dept, Bucharest 020021, Romania.
C3 University of Medicine & Pharmacy of Craiova; University of Medicine &
   Pharmacy of Craiova; Carol Davila University of Medicine & Pharmacy
RP Cioboata, R (corresponding author), Univ Med & Pharm, Pneumol Dept, Craiova 200349, Romania.; Toma, CL (corresponding author), Univ Med & Pharm Carol Davila, Pneumol Dept, Bucharest 020021, Romania.
EM oana_cattana@yahoo.com; alexandra-floriana.nemes@drd.umfcd.ro;
   ramona_cioboata@yahoo.com; claudiatoma@yahoo.co.uk;
   denisa_maria2@yahoo.com; calarasu.cristina@yahoo.com;
   costin.streba@umfcv.ro
RI Nemes, Alexandra/JXX-2372-2024; Streba, Costin/C-4196-2011; Cioboata,
   Ramona/ABF-9084-2021; Calarasu, Cristina/AHC-2476-2022; Toma,
   Claudia/AAS-3064-2021
FU University of Medicine and Pharmacy of Craiova, Romania
FX The Article Processing Charges were funded by the University of Medicine
   and Pharmacy of Craiova, Romania.
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PG 38
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 1WY0M
UT WOS:001475608600001
PM 40283443
DA 2025-06-11
ER

PT J
AU Maniaci, A
   Lavalle, S
   Parisi, FM
   Barbanti, M
   Cocuzza, S
   Iannella, G
   Magliulo, G
   Pace, A
   Lentini, M
   Masiello, E
   La Via, L
AF Maniaci, Antonino
   Lavalle, Salvatore
   Parisi, Federica Maria
   Barbanti, Marco
   Cocuzza, Salvatore
   Iannella, Giannicola
   Magliulo, Giuseppe
   Pace, Annalisa
   Lentini, Mario
   Masiello, Edoardo
   La Via, Luigi
TI Impact of Obstructive Sleep Apnea and Sympathetic Nervous System on
   Cardiac Health: A Comprehensive Review
SO JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
LA English
DT Review
DE sleep apnea; sympathetic nervous system; cardiac risk; cardiovascular
   health; sympathetic activation
ID POSITIVE AIRWAY PRESSURE; BLOOD-PRESSURE; BAROREFLEX SENSITIVITY;
   HEART-RATE; CARDIOVASCULAR-DISEASE; INTERMITTENT HYPOXIA; OXIDATIVE
   STRESS; RISK-FACTOR; COGNITIVE IMPAIRMENT; METABOLIC SYNDROME
AB A prevalent condition linked to an elevated risk of cardiovascular disease is sleep apnea. This review examines the connections between cardiac risk, the sympathetic nervous system, and sleep apnea. The increased risk of hypertension, arrhythmias, myocardial infarction, and heart failure was highlighted in the pathophysiology of sleep apnea and its effect on sympathetic activation. It is also important to consider potential processes such as oxidative stress, inflammation, endothelial dysfunction, and autonomic imbalance that may relate sleep apnea-induced sympathetic activation to cardiac risk. With implications for creating innovative diagnostic and treatment approaches to lessen the cardiovascular effects of sleep apnea, the goal of this investigation is to improve the understanding of the intricate link between sympathetic activity, cardiac risk, and sleep apnea. This study aimed to clarify the complex relationship between cardiovascular health and sleep apnea by synthesizing the available research and highlighting the crucial role played by the sympathetic nervous system in moderating this relationship. Our thorough investigation may have important therapeutic ramifications that will direct the creation of focused therapies to enhance cardiovascular outcomes in sleep apnea sufferers.
C1 [Maniaci, Antonino; Lavalle, Salvatore; Barbanti, Marco] Univ Enna Kore, Dept Med & Surg, I-94100 Enna, Italy.
   [Parisi, Federica Maria; Cocuzza, Salvatore] Univ Catania, Dept Med, Surg Sci & Adv Technol GF Ingrassia ENT Sect, I-95123 Catania, Italy.
   [Iannella, Giannicola; Magliulo, Giuseppe; Pace, Annalisa] Sapienza Univ Rome, Otorhinolaryngol Dept, Policlin Umberto I, Viale Policlin, I-00161 Rome, Italy.
   [Lentini, Mario] ASP Ragusa Hosp Giovanni Paolo II, I-97100 Ragusa, Italy.
   [Masiello, Edoardo] IRCCS San Raffaele Sci Inst, Radiol Unit, Via Olgettina 60, I-20132 Milan, Italy.
   [La Via, Luigi] Azienda Osped Univ Policlin G Rodolico San Marco, Dept Anesthesia & Intens Care, I-95123 Catania, Italy.
C3 Universita Kore di ENNA; University of Catania; Sapienza University
   Rome; University Hospital Sapienza Rome; Vita-Salute San Raffaele
   University; IRCCS Ospedale San Raffaele
RP Lavalle, S (corresponding author), Univ Enna Kore, Dept Med & Surg, I-94100 Enna, Italy.; La Via, L (corresponding author), Azienda Osped Univ Policlin G Rodolico San Marco, Dept Anesthesia & Intens Care, I-95123 Catania, Italy.
EM antonino.maniaci@unikore.it; salvatore.lavalle@unikore.it;
   federicamariaparisi@gmail.com; marco.barbanti@unikore.it;
   s.cocuzza@unict.it; giannicola.iannella@uniroma1.it;
   giuseppe.magliulo@uniroma1.it; annalisa.pace@uniroma1.it;
   marlentini@tiscali.it; luigilavia7@gmail.com
RI Pace, Annalisa/AAP-5561-2020; Iannella, Giannicola/AAL-1553-2020;
   Maniaci, Antonino/AAB-6004-2021; Barbanti, Marco/AAP-4373-2020; La Via,
   Luigi/ACH-7936-2022; Lavalle, Salvatore/JXN-5303-2024
OI Cocuzza, Salvatore/0000-0002-6135-0958; Parisi, Federica
   Maria/0009-0003-0998-726X; lentini, mario/0009-0004-8127-5045; MAGLIULO,
   GIUSEPPE/0000-0003-3052-1969; MANIACI, ANTONINO/0000-0002-1251-0185; La
   Via, Luigi/0000-0002-2156-7554; Barbanti, Marco/0000-0002-4903-5437;
   Iannella, giannicola/0000-0003-1781-2809; , Edoardo
   Masiello/0009-0007-0810-409X; Lavalle, Salvatore/0009-0009-5556-6259
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NR 131
TC 10
Z9 10
U1 0
U2 1
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2308-3425
J9 J CARDIOVASC DEV DIS
JI J. Cardiovasc. Dev. Dis.
PD JUL
PY 2024
VL 11
IS 7
AR 204
DI 10.3390/jcdd11070204
PG 15
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA ZU1P9
UT WOS:001277713900001
PM 39057624
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Alberti, G
   Gana, JC
   Santos, JL
AF Alberti, Gigliola
   Gana, Juan Cristobal
   Santos, Jose L.
TI Fructose, Omega 3 Fatty Acids, and Vitamin E: Involvement in Pediatric
   Non-Alcoholic Fatty Liver Disease
SO NUTRIENTS
LA English
DT Review
DE nonalcoholic fatty liver disease (NAFLD); NASH; nutrition; steatosis;
   sugar; fructose; omega 3 fatty acids; vitamin E
ID SUGAR-SWEETENED BEVERAGES; LIFE-STYLE INTERVENTION;
   CARDIOVASCULAR-DISEASE; DOCOSAHEXAENOIC ACID; INSULIN-RESISTANCE;
   DIETARY FRUCTOSE; URIC-ACID; VISCERAL ADIPOSITY; RANDOMIZED-TRIAL;
   CHILDREN
AB Non-alcoholic fatty liver disease (NAFLD) is currently the most common form of liver disease in both adults and children, becoming the leading cause for liver transplant in many countries. Its prevalence has increased considerably in recent years, mainly due to the explosive increase in pediatric obesity rates. NAFLD is strongly associated with central obesity, diabetes, dyslipidemia and insulin resistance, and it has been considered as the hepatic manifestation of the metabolic syndrome. Its complex pathophysiology involves a series of metabolic, inflammatory and oxidative stress processes, among others. Given the sharp increase in the prevalence of NAFLD and the lack of an appropriate pharmacological approach, it is crucial to consider the prevention/management of the disease based on lifestyle modifications such as the adoption of a healthy nutrition pattern. Herein, we review the literature and discuss the role of three key nutrients involved in pediatric NAFLD: fructose and its participation in metabolism, Omega-3 fatty acids and its anti-inflammatory effects and vitamin E and its action on oxidative stress.
C1 [Alberti, Gigliola; Gana, Juan Cristobal] Pontificia Univ Catolica Chile, Sch Med, Div Pediat, Gastroenterol & Nutr Dept, Santiago 3580000, Chile.
   [Santos, Jose L.] Pontificia Univ Catolica Chile, Sch Med, Dept Nutr Diabet & Metab, Santiago 3580000, Chile.
C3 Pontificia Universidad Catolica de Chile; Pontificia Universidad
   Catolica de Chile
RP Santos, JL (corresponding author), Pontificia Univ Catolica Chile, Sch Med, Dept Nutr Diabet & Metab, Santiago 3580000, Chile.
EM galberti@med.puc.cl; jcgana@gmail.com; jsantosm@uc.cl
RI SANTOS, JOSE/JVD-7250-2023; Alberti, Gigliola/HCI-9021-2022; Gana, Juan
   Cristóbal/AAW-3195-2020; Santos, Jose L./D-1818-2017
OI Gana, Juan Cristobal/0000-0002-0400-2164; Santos, Jose
   L./0000-0003-2895-0369; Alberti, Gigliola/0000-0002-8540-1326
FU Fondecyt [1200839, 11190856]
FX This work has been funded by Fondecyt proyect 1200839 and Fondecyt
   proyect 11190856.
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NR 139
TC 10
Z9 10
U1 1
U2 19
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD NOV
PY 2020
VL 12
IS 11
AR 3531
DI 10.3390/nu12113531
PG 19
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA OX6SS
UT WOS:000593692500001
PM 33212947
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Dey, P
   Mah, E
   Li, JH
   Jalili, T
   Symons, JD
   Bruno, RS
AF Dey, Priyankar
   Mah, Eunice
   Li, Jinhui
   Jalili, Thunder
   Symons, J. David
   Bruno, Richard S.
TI Improved hepatic γ-tocopherol status limits oxidative and inflammatory
   stress-mediated liver injury in db/db mice with
   nonalcoholic steatohepatitis
SO JOURNAL OF FUNCTIONAL FOODS
LA English
DT Article
DE Diabetes; Gamma-tocopherol; iNOS; Insulin resistance; Lipid
   peroxidation; Nonalcoholic steatohepatitis
ID VASCULAR ENDOTHELIAL FUNCTION; VITAMIN-E; ALPHA-TOCOPHEROL;
   INSULIN-RESISTANCE; FATTY LIVER; METABOLIC SYNDROME; GENE-EXPRESSION;
   IN-VIVO; SUPPLEMENTATION; DISEASE
AB gamma-Tocopherol (gamma-T) and its physiological metabolite gamma-carboxyethyl-hydroxychroman (gamma-CEHC) exhibit antioxidant and anti-inflammatory activities. We hypothesized that improved hepatic gamma-T status would protect against NASH in leptin-resistant db/db mice. Wild-type mice were fed a diet without gamma-T, and db/db mice were fed the same diet supplemented with or without gamma-T for 8 wk. Hepatic gamma-T and gamma-CEHC levels were increased (P < .05) compared with db/db controls. Serum ALT and insulin resistance, which were otherwise increased in db/db controls, were 33-38% lower in db/db mice fed gamma-T. Increased hepatic lipid peroxidation in db/db mice was attenuated by dietary gamma-T, which occurred without increasing hepatic Nrf2 mRNA expression. However, gamma-T attenuated hepatic iNOS, MCP-1, TNF-alpha and CRP expression. Histological assessment showed gamma-T-mediated improvements in overall hepatic architecture, specifically by limiting hepatic steatosis. These findings demonstrate that improvements in hepatic gamma-T status protect against liver injury during NASH by reducing inflammation and oxidative stress.
C1 [Dey, Priyankar; Mah, Eunice; Li, Jinhui; Bruno, Richard S.] Ohio State Univ, Human Nutr Program, 1787 Neil Ave,325 Campbell Hall, Columbus, OH 43210 USA.
   [Mah, Eunice] Biofortis Inc, Addison, IL USA.
   [Jalili, Thunder; Symons, J. David] Univ Utah, Dept Nutr & Integrat Physiol, Salt Lake City, UT 84112 USA.
   [Symons, J. David] Univ Utah, Sch Med, Div Endocrinol Metab & Diabet, Salt Lake City, UT 84112 USA.
   [Symons, J. David] Univ Utah, Program Mol Med, Salt Lake City, UT 84112 USA.
C3 University System of Ohio; Ohio State University; Utah System of Higher
   Education; University of Utah; Utah System of Higher Education;
   University of Utah; Utah System of Higher Education; University of Utah
RP Bruno, RS (corresponding author), Ohio State Univ, Human Nutr Program, 1787 Neil Ave,325 Campbell Hall, Columbus, OH 43210 USA.
EM bruno.27@osu.edu
RI Dey, Priyankar/AFE-4921-2022; Bruno, Richard/K-1930-2012
OI Bruno, Richard/0000-0002-6772-2038
FU University of Utah Office of the Vice President for Research [VP-0981];
   USDA-NIFA [2014-67017-21761]; Ohio State University (OSU) Molecular
   Carcinogenesis and Chemoprevention Program of the Comprehensive Cancer
   Center [NIH NCI P30CA16058]; OSU Center for Advanced Functional Foods
   Research and Entrepreneurship; OSU Ohio Agricultural Research and
   Development Center; NIFA [2014-67017-21761, 687115] Funding Source:
   Federal RePORTER
FX Support for these studies was provided by the University of Utah Office
   of the Vice President for Research (Grant VP-0981; JDS), a grant to RSB
   from USDA-NIFA (2014-67017-21761), the Ohio State University (OSU)
   Molecular Carcinogenesis and Chemoprevention Program of the
   Comprehensive Cancer Center (NIH NCI P30CA16058), the OSU Center for
   Advanced Functional Foods Research and Entrepreneurship, and the OSU
   Ohio Agricultural Research and Development Center. The authors are
   grateful to Jose Llobrera at Designs for Health, Inc. for kindly
   providing the gamma-T used in these studies.
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NR 77
TC 11
Z9 11
U1 0
U2 15
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1756-4646
J9 J FUNCT FOODS
JI J. Funct. Food.
PD JAN
PY 2018
VL 40
BP 670
EP 678
DI 10.1016/j.jff.2017.12.007
PG 9
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA GA0LW
UT WOS:000428005500072
OA Bronze
DA 2025-06-11
ER

PT J
AU Chernikov, AV
   Gudkov, SV
   Usacheva, AM
   Bruskov, VI
AF Chernikov, A. V.
   Gudkov, S. V.
   Usacheva, A. M.
   Bruskov, V. I.
TI Exogenous 8-Oxo-7,8-dihydro-2′-deoxyguanosine: Biomedical Properties,
   Mechanisms of Action, and Therapeutic Potential
SO BIOCHEMISTRY-MOSCOW
LA English
DT Review
DE exogenous 8-oxo-7; 8-dihydro-2 '-deoxyguanosine; free 8-oxo-7;
   8-dihydroguanine; oxidized extracellular DNA; inflammation; small
   GTPases
ID OXIDATIVE DNA-DAMAGE; OXIDIZED MITOCHONDRIAL-DNA; TRANSCRIPTOME ANALYSIS
   REVEALS; IN-VITRO; INFLAMMATORY RESPONSES; METABOLIC SYNDROME;
   GENE-EXPRESSION; EXCISION-REPAIR; RHO GTPASES; CELL-LINE
AB 8-Oxo-7,8-dihydroguanine (8-oxo-G) is a key biomarker of oxidative damage to DNA in cells, and its genotoxicity is well-studied. In recent years, it has been confirmed experimentally that free 8-oxo-G and molecules containing it are not merely inert products of DNA repair or degradation, but they are actively involved in intracellular signaling. In this review, data are systematized indicating that free 8-oxo-G and oxidized (containing 8-oxo-G) extracellular DNA function in the body as mediators of stress signaling and initiate inflammatory and immune responses to maintain homeostasis under the action of external pathogens, whereas exogenous 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxo-dGuo) exhibits pronounced antiinflammatory and antioxidant properties. This review describes known action mechanisms of oxidized guanine and 8-oxo-G-containing molecules. Prospects for their use as a therapeutic target are considered, as well as a pharmaceutical agent for treatment of a wide range of diseases whose pathogenesis is significantly contributed to by inflammation and oxidative stress.
C1 [Chernikov, A. V.; Usacheva, A. M.; Bruskov, V. I.] Russian Acad Sci, Inst Theoret & Expt Biophys, Pushchino 142292, Moscow Region, Russia.
   [Gudkov, S. V.] Moscow Reg Res & Clin Inst MONIKI, Moscow 129110, Russia.
   [Gudkov, S. V.] Russian Acad Sci, Prokhorov Inst Gen Phys, Moscow 119991, Russia.
   [Gudkov, S. V.] Lobachevsky State Univ Nizhnii Novgorod, Nizhnii Novgorod 603950, Russia.
   [Bruskov, V. I.] Pushchino State Res Inst Nat Sci, Pushchino 142290, Moscow Region, Russia.
C3 Russian Academy of Sciences; Pushchino Scientific Center for Biological
   Research (PSCBI) of the Russian Academy of Sciences; Institute of
   Theoretical & Experimental Biophysics; Russian Academy of Sciences;
   Prokhorov General Physics Institute of the Russian Academy of Sciences;
   Lobachevsky State University of Nizhni Novgorod
RP Bruskov, VI (corresponding author), Russian Acad Sci, Inst Theoret & Expt Biophys, Pushchino 142292, Moscow Region, Russia.; Bruskov, VI (corresponding author), Pushchino State Res Inst Nat Sci, Pushchino 142290, Moscow Region, Russia.
EM anatole@inbox.ru; bruskov_vi@rambler.ru
RI Bruskov, Vadim/P-9592-2015; Gudkov, Sergey/B-6263-2013; Chernikov,
   Anatoly/P-3061-2016; Usacheva, Anna/J-7543-2018
OI Gudkov, Sergey/0000-0002-8814-6906; Chernikov,
   Anatoly/0000-0003-0901-6730
FU Russian Foundation for Basic Research [17-44-500476-p_a]
FX This work was supported by the Russian Foundation for Basic Research
   (project No. 17-44-500476-p_a).
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NR 119
TC 19
Z9 19
U1 0
U2 9
PU MAIK NAUKA/INTERPERIODICA/SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013-1578 USA
SN 0006-2979
EI 1608-3040
J9 BIOCHEMISTRY-MOSCOW+
JI Biochem.-Moscow
PD DEC
PY 2017
VL 82
IS 13
BP 1686
EP 1701
DI 10.1134/S0006297917130089
PG 16
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA FR4XW
UT WOS:000419070900008
PM 29523066
DA 2025-06-11
ER

PT J
AU Xu, LL
   Tang, D
   Guan, MP
   Xie, CH
   Xue, YM
AF Xu, Lingling
   Tang, Dou
   Guan, Meiping
   Xie, Cuihua
   Xue, Yaoming
TI Effect of High-Fat Diet on Peripheral Neuropathy in C57BL/6 Mice
SO INTERNATIONAL JOURNAL OF ENDOCRINOLOGY
LA English
DT Article
ID ENDOTHELIAL GROWTH-FACTOR; IMPAIRED GLUCOSE-TOLERANCE; SMALL-FIBER
   NEUROPATHY; METABOLIC SYNDROME; EXPRESSION; OBESITY; RISK;
   COMPLICATIONS; ANGIOGENESIS; REGENERATION
AB Objective. Dyslipidemia may contribute to the development of peripheral neuropathy, even in prediabetics; however, few studies have evaluated vascular dysfunction and oxidative stress in patients with peripheral neuropathy. Methods. Using high-fat diet(HFD-) induced prediabetic C57BL/6 mice, we assessed motor and sensory nerve conduction velocity (NCV) using a BIOPAC System and thermal algesia with a Plantar Test (Hargreaves'method) AnalgesiaMeter. Intraepidermal nerve fiber density and mean dendrite length were tested following standard protocols. Vascular endothelial growth factor-A (VEGF-A) and 12/15-lipoxygenase (12/15-LOX) were evaluated by immunohistochemistry and Western blot, respectively. Results. HFD-fed mice showed deficits in motor and sensory NCV, thermal hyperalgesia, reduced mean dendrite length, and VEGF-A expression in the plantar skin and increased 12/15-LOX in the sciatic nerve (P < 0.05 compared with controls). Conclusion. HFD may cause large myelinated nerve and small sensory nerve fiber damage, thus leading to neuropathy. The mean dendrite length may be a more sensitive marker for early detection of peripheral neuropathy. Reduced blood supply to the nerves and increased oxidative stress may contribute to the development and severity of peripheral neuropathy.
C1 [Xu, Lingling; Tang, Dou; Guan, Meiping; Xie, Cuihua; Xue, Yaoming] Southern Med Univ, Nanfang Hosp, Dept Endocrinol, Guangzhou 510515, Guangdong, Peoples R China.
C3 Southern Medical University - China
RP Xue, YM (corresponding author), Southern Med Univ, Nanfang Hosp, Dept Endocrinol, Guangzhou 510515, Guangdong, Peoples R China.
EM yaomingxue123@yeah.net
FU Doctor Project on Natural Science Fund of Guangdong Province
   [10451051501005781]
FX This work was supported by the Doctor Project on Natural Science Fund of
   Guangdong Province (no. 10451051501005781).
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NR 35
TC 17
Z9 22
U1 0
U2 14
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1687-8337
EI 1687-8345
J9 INT J ENDOCRINOL
JI Int. J. Endocrinol.
PY 2014
VL 2014
AR 305205
DI 10.1155/2014/305205
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA AT6ER
UT WOS:000345032500001
PM 25404943
OA Green Submitted, gold, Green Published
DA 2025-06-11
ER

PT J
AU Peng, HY
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   Wang, Xiaoxiao
   Liu, Chi
   Wan, Zhengwei
TI Unraveling the Connection between PCOS and renal Complications: Current
   insights and Future Directions
SO DIABETES RESEARCH AND CLINICAL PRACTICE
LA English
DT Review
DE Chronic Kidney Disease (CKD); Polycystic ovary syndrome (PCOS); Insulin
   Resistance (IR); Androgen; Metabolic disorder; Inflammation; Oxidative
   Stress
ID POLYCYSTIC-OVARY-SYNDROME; CHRONIC KIDNEY-DISEASE; PEPTIDE-1 RECEPTOR
   AGONISTS; INSULIN-RESISTANCE; OXIDATIVE STRESS; TESTOSTERONE PRODUCTION;
   MITOCHONDRIAL-FUNCTION; ORAL-CONTRACEPTIVES; METABOLIC SYNDROME;
   ANDROGEN EXCESS
AB Polycystic ovary syndrome (PCOS) represents the most prevalent endocrine disorder among women of reproductive age, affecting approximately 5-18% of females worldwide. Characterized by irregular ovulation, hyperandrogenism, and polycystic ovaries, hyperandrogenism is the defining feature. Recent evidence highlights that, in addition to its notable reproductive and metabolic consequences, PCOS may also contribute to an elevated risk of renal complications. This increased risk is attributed to chronic low-grade inflammation, hormonal dysregulation, and disturbances in lipid metabolism inherent to the condition. However, the pathological mechanisms, clinical manifestations, and progression of secondary renal damage in this cohort remain insufficiently studied. This review consolidates current understanding of the relationship between PCOS and chronic kidney disease (CKD), aiming to clarify potential mechanisms by which PCOS may induce secondary renal dysfunction, encompassing both direct renal impairment and indirect damage mediated through systemic alterations. Furthermore, it advocates for comprehensive management strategies to mitigate renal risks in patients with PCOS, emphasizing the necessity of multidisciplinary approaches and further research to address these critical gaps.
C1 [Peng, Haoyu; Ren, Junyi; Zhao, Yang; Fang, Xinyi] Univ Elect Sci & Technol China, Sch Med, Chengdu, Peoples R China.
   [Wang, Xiaoxiao] Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Sch Med, Dept Organ Transplantat, Chengdu, Peoples R China.
   [Zhao, Yang; Wan, Zhengwei] Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Sch Med, Dept Hlth Management Ctr, Chengdu, Peoples R China.
   [Zhao, Yang; Wan, Zhengwei] Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Sch Med, Inst Hlth Management, Chengdu, Peoples R China.
   [Liu, Chi] Univ Elect Sci & Technol, Sichuan Prov Peoples Hosp, Sichuan Clin Res Ctr Kidney Dis, Dept Nephrol, Chengdu, Peoples R China.
C3 University of Electronic Science & Technology of China; Sichuan
   Provincial People's Hospital; University of Electronic Science &
   Technology of China; Sichuan Provincial People's Hospital; University of
   Electronic Science & Technology of China; Sichuan Provincial People's
   Hospital; University of Electronic Science & Technology of China;
   University of Electronic Science & Technology of China; Sichuan
   Provincial People's Hospital
RP Peng, HY (corresponding author), Univ Elect Sci & Technol China, Sch Med, Chengdu, Peoples R China.; Wan, ZW (corresponding author), Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Sch Med, Dept Hlth Management Ctr, Chengdu, Peoples R China.; Wan, ZW (corresponding author), Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Sch Med, Inst Hlth Management, Chengdu, Peoples R China.; Liu, C (corresponding author), Univ Elect Sci & Technol, Sichuan Prov Peoples Hosp, Sichuan Clin Res Ctr Kidney Dis, Dept Nephrol, Chengdu, Peoples R China.
EM phy030119@163.com; liuchi_1230@163.com; 18715799366@163.com
RI Peng, Haoyu/MVY-5111-2025; Ren, Junyi/NGQ-7091-2025
FU Discipline Construction Fund of Sichuan Provincial People's Hospital;
   Sichuan Science and Technology Program [2022YFS0331]; Sichuan Provincial
   Health Commission [21PJ083]; National Natural Science Foundation of
   China [82200810]; Natural Science Foundation of Sichuan [2023NSFSC1526];
   Foundation of Applied Basic Research Project of Sichuan Provincial
   Science and Technology [2020YJ0179]; Foundation for Young Talent Fund of
   Sichuan Provincial People's Hospital [2022QN02]
FX This work was supported by the Discipline Construction Fund of Sichuan
   Provincial People's Hospital; Sichuan Science and Technology Program
   (2022YFS0331) ; Sichuan Provincial Health Commission (21PJ083) ; the
   National Natural Science Foundation of China (82200810) ; and the
   Natural Science Foundation of Sichuan (2023NSFSC1526) . Additional
   support came from the 2020 High-level Overseas Chinese Talent Returning
   Funding; the Foundation of Applied Basic Research Project of Sichuan
   Provincial Science and Technology (2020YJ0179) ; the Foundation for
   Young Talent Fund of Sichuan Provincial People's Hospital (2022QN02) ;
   and the Discipline Construction Fund of Sichuan Provincial People's
   Hospital.
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NR 288
TC 0
Z9 0
U1 4
U2 4
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0168-8227
EI 1872-8227
J9 DIABETES RES CLIN PR
JI Diabetes Res. Clin. Pract.
PD JUN
PY 2025
VL 224
AR 112235
DI 10.1016/j.diabres.2025.112235
PG 14
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 2TD6P
UT WOS:001490700800001
PM 40334925
DA 2025-06-11
ER

PT J
AU Foster, C
   Gagnon, CA
   Ashraf, AP
AF Foster, Christy
   Gagnon, Charles A.
   Ashraf, Ambika P.
TI Altered lipid metabolism and the development of metabolic-associated
   fatty liver disease
SO CURRENT OPINION IN LIPIDOLOGY
LA English
DT Review
DE Insulin resistance; lipoprotein metabolism; metabolic syndrome;
   metabolic-associated fatty liver disease
ID CARBOHYDRATE-RESTRICTED DIET; RANDOMIZED CONTROLLED-TRIAL; NONALCOHOLIC
   STEATOHEPATITIS; FAMILIAL HYPOBETALIPOPROTEINEMIA; TRIGLYCERIDE LEVELS;
   HEPATIC STEATOSIS; OBETICHOLIC ACID; VITAMIN-E; PLACEBO; PROTEIN
AB Purpose of reviewAn increasing amount of research has underscored the significant role of lipoproteins in the pathogenesis of metabolic-associated fatty liver disease (MAFLD). This comprehensive review examines the intricate relationship between lipoprotein abnormalities and the development of MAFLD.Recent findingsAtherogenic dyslipidemia seen in insulin resistance states play a significant role in initiating and exacerbating hepatic lipid accumulation. There are also specific genetic factors (PNPLA3, TM6SF2, MBOAT7, HSD17B13, GCKR-P446L) and transcription factors (SREBP-2, FXR, and LXR9) that increase susceptibility to both lipoprotein disorders and MAFLD. Most monogenic primary lipid disorders do not cause hepatic steatosis unless accompanied by metabolic stress. Hepatic steatosis occurs in the presence of secondary systemic metabolic stress in conjunction with predisposing environmental factors that lead to insulin resistance. Identifying specific aberrant lipoprotein metabolic factors promoting hepatic fat accumulation and subsequently exacerbating steatohepatitis will shed light on potential targets for therapeutic interventions.SummaryThe clinical implications of interconnection between genetic factors and an insulin resistant environment that predisposes MAFLD is many fold. Potential therapeutic strategies in preventing or mitigating MAFLD progression include lifestyle modifications, pharmacological interventions, and emerging therapies targeting aberrant lipoprotein metabolism.
C1 [Foster, Christy; Ashraf, Ambika P.] Univ Alabama Birmingham, Dept Pediat, Div Pediat Endocrinol & Diabet, CPP M30,1601 4th Ave South, Birmingham, AL 35233 USA.
   [Gagnon, Charles A.] Univ Alabama Birmingham, Marnix E Heersink Sch Med, Birmingham, AL USA.
C3 University of Alabama System; University of Alabama Birmingham;
   University of Alabama System; University of Alabama Birmingham
RP Foster, C (corresponding author), Univ Alabama Birmingham, Dept Pediat, Div Pediat Endocrinol & Diabet, CPP M30,1601 4th Ave South, Birmingham, AL 35233 USA.
EM cafoster@uabmc.edu
RI Ashraf, Ambika./KWU-9016-2024
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NR 74
TC 2
Z9 2
U1 3
U2 7
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0957-9672
EI 1473-6535
J9 CURR OPIN LIPIDOL
JI Curr. Opin. Lipidology
PD AUG
PY 2024
VL 35
IS 4
BP 200
EP 207
DI 10.1097/MOL.0000000000000933
PG 8
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism; Peripheral
   Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism;
   Cardiovascular System & Cardiology
GA XN1Z5
UT WOS:001262286300004
PM 38484227
DA 2025-06-11
ER

PT J
AU Hegberg, NJ
   Hayes, JP
   Hayes, SM
AF Hegberg, Nicole J.
   Hayes, Jasmeet P.
   Hayes, Scott M.
TI Exercise Intervention in PTSD: A Narrative Review and Rationale for
   Implementation
SO FRONTIERS IN PSYCHIATRY
LA English
DT Review
DE aerobic exercise; physical activity; fitness; emotion regulation;
   cognition; MRI; fMRI; PTSD
ID POSTTRAUMATIC-STRESS-DISORDER; WHITE-MATTER INTEGRITY;
   PHYSICAL-ACTIVITY; AEROBIC EXERCISE; COGNITIVE FUNCTION;
   CARDIORESPIRATORY FITNESS; INFLAMMATORY MARKERS; HIPPOCAMPAL VOLUME;
   METABOLIC SYNDROME; SYMPTOM SEVERITY
AB Posttraumatic stress disorder (PTSD) is a prominentmental health problemin veteran and community populations. There is accumulating evidence to suggest that aerobic exercise may serve as an effective treatment option for individuals with PTSD. The purpose of this review is to summarize the existing literature exploring aerobic exercise and PTSD and briefly discuss potential mechanisms of PTSD symptom reduction. A search of electronic databases and reference sections of relevant articles published through October 1, 2018 revealed 19 relevant studies that examined aerobic exercise and PTSD symptomatology. A narrative review of extant studies provides encouraging evidence that aerobic exercise interventions alone or as an adjunct to standard treatmentmay positively impact PTSD symptoms. Potential mechanisms by which aerobic exercise could exert a positive impact in PTSD include exposure and desensitization to internal arousal cues, enhanced cognitive function, exercise-induced neuroplasticity, normalization of hypothalamic pituitary axis (HPA) function, and reductions in inflammatory markers. Randomized clinical trials and translational neuroscience approaches are required to clarify the efficacy of exercise intervention for PTSD and elucidate potential mechanisms of exercise-induced PTSD symptom reduction.
C1 [Hegberg, Nicole J.; Hayes, Scott M.] Boston Univ, Sch Med, Memory Disorders Res Ctr, VA Boston Healthcare Syst, Boston, MA 02118 USA.
   [Hayes, Jasmeet P.; Hayes, Scott M.] Ohio State Univ, Dept Psychol, Columbus, OH 43210 USA.
   [Hayes, Jasmeet P.; Hayes, Scott M.] Ohio State Univ, Chron Brain Injury Initiat, Columbus, OH 43210 USA.
C3 Harvard University; Harvard University Medical Affiliates; US Department
   of Veterans Affairs; Veterans Health Administration (VHA); VA Boston
   Healthcare System; Boston University; University System of Ohio; Ohio
   State University; University System of Ohio; Ohio State University
RP Hayes, SM (corresponding author), Boston Univ, Sch Med, Memory Disorders Res Ctr, VA Boston Healthcare Syst, Boston, MA 02118 USA.; Hayes, SM (corresponding author), Ohio State Univ, Dept Psychol, Columbus, OH 43210 USA.; Hayes, SM (corresponding author), Ohio State Univ, Chron Brain Injury Initiat, Columbus, OH 43210 USA.
EM hayes.1074@osu.edu
RI Hayes, Scott/AAL-8682-2020; Hayes, Jasmeet/AAN-4150-2020
OI Hayes, Scott/0000-0002-1185-5149
FU National Institute on Aging of the National Institutes of Health
   [R21AG056921]; Ohio State University Discovery Themes Chronic Brain
   Injury Initiative; Boston University Spivack Emerging Leaders in
   Neurosciences Award
FX This work was supported by the National Institute on Aging of the
   National Institutes of Health (R21AG056921 awarded to SH), The Ohio
   State University Discovery Themes Chronic Brain Injury Initiative (SH
   and JH) and the Boston University Spivack Emerging Leaders in
   Neurosciences Award (SH). The content is solely the responsibility of
   the authors and does not necessarily represent the official views of the
   National Institutes of Health.
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NR 130
TC 88
Z9 99
U1 11
U2 60
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-0640
J9 FRONT PSYCHIATRY
JI Front. Psychiatry
PD MAR 21
PY 2019
VL 10
AR 133
DI 10.3389/fpsyt.2019.00133
PG 13
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA HP7FK
UT WOS:000461852900001
PM 30949075
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Hua, F
   Yu, JJ
   Hu, ZW
AF Hua, Fang
   Yu, Jiao-Jiao
   Hu, Zhuo-Wei
TI Diabetes and cancer, common threads and missing links
SO CANCER LETTERS
LA English
DT Review
DE Hyperinsulinemia; Insulin resistance; Inflammation; Obesity; ER-stress;
   Autophagy
ID GROWTH-FACTOR-I; INDEPENDENT RISK-FACTOR; INSULIN-RECEPTOR IR; BODY-MASS
   INDEX; PANCREATIC-CANCER; METABOLIC SYNDROME; HEPATOCELLULAR-CARCINOMA;
   CELL-PROLIFERATION; ENDOMETRIAL CANCER; LIVER-CANCER
AB Diabetes mellitus is a serious and growing health problem worldwide and is associated with severe acute and chronic complications. Accruing epidemiological and clinical evidence have suggested that an increased cancer incidence is associated with diabetes as well as certain diabetes risk factors and diabetes medications. Several pathophysiological mechanisms for this relationship have been postulated, including insulin resistance and hyperinsulinemia, enhanced inflammation, aberrant metabolic state, endoplasmic reticulum stress, and deregulation of autophagy. In addition to these potential mechanisms, a number of common risk factors, including obesity, may be behind the association between diabetes and cancer. Furthermore, different anti-diabetic medications may modify cancer risk and mortality in patients with diabetes. This Review discusses evidence to support the relationship between diabetes and cancer development as well as the underlying mechanisms. We also discuss the relationship of current diabetes treatments and cancer risk or prognosis. Understanding the mechanisms that connect type 2 diabetes or diabetes treatments to cancer are crucial for establishing the fundamental strategies concerning about primary prevention, early detection and effective therapy against these diseases. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
C1 [Hu, Zhuo-Wei] Chinese Acad Med Sci, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Immunol & Canc Pharmacol Grp, Beijing 100050, Peoples R China.
   Peking Union Med Coll, Beijing 100050, Peoples R China.
C3 Chinese Academy of Medical Sciences - Peking Union Medical College;
   Institute of Materia Medica - CAMS; Chinese Academy of Medical Sciences
   - Peking Union Medical College; Peking Union Medical College
RP Hu, ZW (corresponding author), Chinese Acad Med Sci, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Immunol & Canc Pharmacol Grp, Beijing 100050, Peoples R China.
EM huzhuowei@imm.ac.cn
RI Jiaojiao, Yu/JFJ-6578-2023
FU National Natural Science Foundation of China [81273529, 81472717]; Basic
   Research Program of the Peking Union Medical College [33320140070];
   Basic Research Program of Institute of Materia Medica [2014ZD01]
FX This work was supported by grants from National Natural Science
   Foundation of China (81273529 to ZWH; 81472717 to FH). FH was also
   supported by grants from the Basic Research Program of the Peking Union
   Medical College (33320140070) and from the Basic Research Program of
   Institute of Materia Medica (2014ZD01).
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NR 93
TC 55
Z9 63
U1 0
U2 72
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0304-3835
EI 1872-7980
J9 CANCER LETT
JI Cancer Lett.
PD APR 28
PY 2016
VL 374
IS 1
BP 54
EP 61
DI 10.1016/j.canlet.2016.02.006
PG 8
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA DH4NM
UT WOS:000372762700006
PM 26879686
DA 2025-06-11
ER

PT J
AU Cho, SY
   Roh, HT
AF Cho, Su Youn
   Roh, Hee Tae
TI Effects of aerobic exercise training on peripheral brain-derived
   neurotrophic factor and eotaxin-1 levels in obese young men
SO JOURNAL OF PHYSICAL THERAPY SCIENCE
LA English
DT Article
DE Aerobic exercise; BDNF; CCL11
ID TYPE-2 DIABETES-MELLITUS; OXIDATIVE STRESS; METABOLIC SYNDROME;
   NEUROINFLAMMATION; CHEMOKINES; CCL11
AB [Purpose] The aim of the present study was to investigate the effects of aerobic exercise training on the levels of peripheral brain-derived neurotrophic factor and eotaxin-1 in obese young men. [Subjects and Methods] The subjects included sixteen obese young men with a body mass index greater than 25 kg/m(2). They were randomly divided between control and exercise groups (n = 8 in each group). The exercise group performed treadmill exercise for 40 min, 3 times a week for 8 weeks at the intensity of 70% heart rate reserve. Blood collection was performed to examine the levels of serum glucose, plasma malonaldehyde, serum brain-derived neurotrophic factor, and plasma eotaxin-1 before and after the intervention (aerobic exercise training). [Results] Following the intervention, serum BDNF levels were significantly higher, while serum glucose, plasma MDA, and plasma eotaxin-1 levels were significantly lower than those prior to the intervention in the exercise group. [Conclusion] Aerobic exercise training can induce neurogenesis in obese individuals by increasing the levels of brain-derived neurotrophic factor and reducing the levels of eotaxin-1. Alleviation of oxidative stress is possibly responsible for such changes.
C1 [Cho, Su Youn] Yonsei Univ, Dept Phys Educ, Exercise Physiol Lab, Seoul 120749, South Korea.
   [Roh, Hee Tae] Dong A Univ, Coll Arts & Phys Educ, Dept Phys Educ, 37 Nakdong Daero 550 Beon Gil, Busan 604714, South Korea.
C3 Yonsei University; Dong A University
RP Roh, HT (corresponding author), Dong A Univ, Coll Arts & Phys Educ, Dept Phys Educ, 37 Nakdong Daero 550 Beon Gil, Busan 604714, South Korea.
EM dau0409@dau.ac.kr
FU National Research Foundation of Korea - Korean Government
   [NRF-2013S1A5B5A07049580]
FX This work was supported by the National Research Foundation of Korea
   Grant funded by the Korean Government (NRF-2013S1A5B5A07049580).
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NR 18
TC 17
Z9 20
U1 0
U2 1
PU SOC PHYSICAL THERAPY SCIENCE
PI TOKYO
PA C/O PUBLICATION CENTER, 1-24-12 SUGAMO, TOSHIMA-KU, TOKYO, 170-0002,
   JAPAN
SN 0915-5287
EI 2187-5626
J9 J PHYS THER SCI
JI J. Phys. Ther. Sci.
PD APR
PY 2016
VL 28
IS 4
BP 1355
EP 1358
DI 10.1589/jpts.28.1355
PG 4
WC Rehabilitation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Rehabilitation
GA DP9ZH
UT WOS:000378856200053
PM 27390441
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Fabbrini, E
   Magkos, F
AF Fabbrini, Elisa
   Magkos, Faidon
TI Hepatic Steatosis as a Marker of Metabolic Dysfunction
SO NUTRIENTS
LA English
DT Review
DE NAFLD; nonalcoholic fatty liver disease; liver steatosis; glucose
   metabolism; lipid metabolism; insulin resistance; obesity; fatty acid
   metabolism; lipolysis; VLDL secretion
ID NONALCOHOLIC FATTY LIVER; ENDOPLASMIC-RETICULUM STRESS; DE-NOVO
   LIPOGENESIS; INTRAHEPATIC TRIGLYCERIDE CONTENT; DENSITY LIPOPROTEIN
   PRODUCTION; SYSTEMIC INSULIN-RESISTANCE; ACID OXIDATION;
   APOLIPOPROTEIN-B; GENE-EXPRESSION; ADIPOSE-TISSUE
AB Nonalcoholic fatty liver disease (NAFLD) is the liver manifestation of the complex metabolic derangements associated with obesity. NAFLD is characterized by excessive deposition of fat in the liver (steatosis) and develops when hepatic fatty acid availability from plasma and de novo synthesis exceeds hepatic fatty acid disposal by oxidation and triglyceride export. Hepatic steatosis is therefore the biochemical result of an imbalance between complex pathways of lipid metabolism, and is associated with an array of adverse changes in glucose, fatty acid, and lipoprotein metabolism across all tissues of the body. Intrahepatic triglyceride (IHTG) content is therefore a very good marker (and in some cases may be the cause) of the presence and the degree of multiple-organ metabolic dysfunction. These metabolic abnormalities are likely responsible for many cardiometabolic risk factors associated with NAFLD, such as insulin resistance, type 2 diabetes mellitus, and dyslipidemia. Understanding the factors involved in the pathogenesis and pathophysiology of NAFLD will lead to a better understanding of the mechanisms responsible for the metabolic complications of obesity, and hopefully to the discovery of novel effective treatments for their reversal.
C1 [Magkos, Faidon] Washington Univ, Sch Med, Ctr Human Nutr, St Louis, MO 63110 USA.
   Washington Univ, Sch Med, Atkins Ctr Excellence Obes Med, St Louis, MO 63110 USA.
C3 Washington University (WUSTL); Washington University (WUSTL)
RP Magkos, F (corresponding author), Washington Univ, Sch Med, Ctr Human Nutr, St Louis, MO 63110 USA.
EM efabbrini@dom.wustl.edu; fmagkos@dom.wustl.edu
RI Magkos, Faidon/CAA-9939-2022; Magkos, Faidon/B-4384-2010
OI Magkos, Faidon/0000-0002-1312-7364
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NR 152
TC 150
Z9 167
U1 3
U2 41
PU MDPI AG
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JUN
PY 2015
VL 7
IS 6
BP 4995
EP 5019
DI 10.3390/nu7064995
PG 25
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA CL9FN
UT WOS:000357281800062
PM 26102213
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Glastras, SJ
   Tsang, M
   Teh, R
   Chen, H
   McGrath, RT
   Zaky, AA
   Pollock, CA
   Saad, S
AF Glastras, Sarah J.
   Tsang, Michael
   Teh, Rachel
   Chen, Hui
   McGrath, Rachel T.
   Zaky, Amgad A.
   Pollock, Carol A.
   Saad, Sonia
TI Maternal Obesity Promotes Diabetic Nephropathy in Rodent Offspring
SO SCIENTIFIC REPORTS
LA English
DT Article
ID MONOCYTE CHEMOATTRACTANT PROTEIN-1; INSULIN-RESISTANCE;
   GLUCOSE-INTOLERANCE; METABOLIC SYNDROME; DISEASE; MICE; PATHOGENESIS;
   ASSOCIATION; DYSFUNCTION; PREGNANCY
AB Maternal obesity is known to increase the risk of obesity and diabetes in offspring. Though diabetes is a key risk factor for the development of chronic kidney disease (CKD), the relationship between maternal obesity and CKD has not been clearly defined. In this study, a mouse model of maternal obesity was employed to determine the impact of maternal obesity on development of diabetic nephropathy in offspring. Female C57BL/6 mice were fed high-fat diet (HFD) for six weeks prior to mating, during gestation and lactation. Male offspring were weaned to normal chow diet. At postnatal Week 8, offspring were randomly administered low dose streptozotocin (STZ, 55 mg/kg/day for five days) to induce diabetes. Assessment of renal damage took place at postnatal Week 32. We found that offspring of obese mothers had increased renal fibrosis, inflammation and oxidative stress. Importantly, offspring exposed to maternal obesity had increased susceptibility to renal damage when an additional insult, such as STZ-induced diabetes, was imposed. Specifically, renal inflammation and oxidative stress induced by diabetes was augmented by maternal obesity. Our findings suggest that developmental programming induced by maternal obesity has implications for renal health in offspring. Maternal obesity should be considered a risk factor for CKD.
C1 [Glastras, Sarah J.; Teh, Rachel; Zaky, Amgad A.; Pollock, Carol A.; Saad, Sonia] Univ Sydney, Dept Med, Kolling Inst, Sydney, NSW 2006, Australia.
   [Glastras, Sarah J.; McGrath, Rachel T.] Royal N Shore Hosp, Dept Diabet Endocrinol & Metab, St Leonards, NSW 2065, Australia.
   [Tsang, Michael; Chen, Hui] Univ Technol Sydney, Fac Sci, Sch Life Sci, Sydney, NSW 2007, Australia.
C3 University of Sydney; Kolling Institute of Medical Research; Royal North
   Shore Hospital; University of Technology Sydney
RP Glastras, SJ (corresponding author), Univ Sydney, Dept Med, Kolling Inst, Sydney, NSW 2006, Australia.; Glastras, SJ (corresponding author), Royal N Shore Hosp, Dept Diabet Endocrinol & Metab, St Leonards, NSW 2065, Australia.
EM sarah.glastras@sydney.edu.au
RI Saad, Sonia/D-2914-2015; McGrath, Rachel/F-7063-2015; Pollock,
   Carol/H-1117-2015; Glastras, Sarah/AAL-2541-2020; Zaky,
   Amgad/D-8367-2015; Chen, Hui/D-2005-2014
OI Teh, Rachel/0000-0003-1396-2295; Saad, Sonia/0000-0001-8067-8046; Zaky,
   Amgad/0000-0001-7738-5330; McGrath, Rachel/0000-0003-3453-058X;
   Glastras, Sarah/0000-0002-9317-1348; Chen, Hui/0000-0001-6883-3752
FU Diabetes Australia Research Trust (DART)/Diabetes Research Grant Program
FX We wish to thank Prof. Anthony Gill of the Department of Anatomical
   Pathology, Royal North Shore Hospital, St Leonards, NSW, Australia for
   assisting with histological preparation of samples. We wish to thank Dr.
   Muh Geot Wong for his assistance in the histological analysis. This work
   was supported by a grant from Diabetes Australia Research Trust
   (DART)/Diabetes Research Grant Program 2015.
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NR 50
TC 27
Z9 28
U1 0
U2 11
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD JUN 9
PY 2016
VL 6
AR 27769
DI 10.1038/srep27769
PG 9
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA DN9JM
UT WOS:000377395700001
PM 27277011
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Han, YQ
   Sun, QW
   Chen, W
   Gao, Y
   Ye, J
   Chen, YM
   Wang, TT
   Gao, LL
   Liu, YL
   Yang, YF
AF Han, Yanqi
   Sun, Qianwen
   Chen, Wei
   Gao, Yue
   Ye, Jun
   Chen, Yanmin
   Wang, Tingting
   Gao, Lili
   Liu, Yuling
   Yang, Yanfang
TI New advances of adiponectin in regulating obesity and related metabolic
   syndromes
SO JOURNAL OF PHARMACEUTICAL ANALYSIS
LA English
DT Review
DE Adiponectin; Obesity; Metabolic syndrome; Regulation
ID NECROSIS-FACTOR-ALPHA; ADIPOSE-TISSUE; INSULIN SENSITIVITY; COLLAGENOUS
   DOMAIN; HEPATOCELLULAR-CARCINOMA; GENE-EXPRESSION; PPAR-GAMMA;
   CIRCULATING ADIPONECTIN; GLOBULAR ADIPONECTIN; OXIDATIVE STRESS
AB Obesity and related metabolic syndromes have been recognized as important disease risks, in which the role of adipokines cannot be ignored. Adiponectin (ADP) is one of the key adipokines with various beneficial effects, including improving glucose and lipid metabolism, enhancing insulin sensitivity, reducing oxidative stress and inflammation, promoting ceramides degradation, and stimulating adipose tissue vascularity. Based on those, it can serve as a positive regulator in many metabolic syndromes, such as type 2 diabetes (T2D), cardiovascular diseases, non-alcoholic fatty liver disease (NAFLD), sarcopenia, neurodegenerative diseases, and certain cancers. Therefore, a promising therapeutic approach for treating various metabolic diseases may involve elevating ADP levels or activating ADP receptors. The modulation of ADP genes, multimerization, and secretion covers the main processes of ADP generation, providing a comprehensive orientation for the development of more appropriate therapeutic strategies. In order to have a deeper understanding of ADP, this paper will provide an all-encompassing review of ADP. (c) 2023 The Authors. Published by Elsevier B.V. on behalf of Xi'an Jiaotong University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
C1 [Han, Yanqi; Sun, Qianwen; Chen, Wei; Gao, Yue; Ye, Jun; Chen, Yanmin; Wang, Tingting; Gao, Lili; Liu, Yuling; Yang, Yanfang] Chinese Acad Med Sci & Peking Union Med Coll, State Key Lab Bioact Subst & Funct Nat Med, Inst Mat Med, Beijing 100050, Peoples R China.
   [Han, Yanqi; Sun, Qianwen; Chen, Wei; Gao, Yue; Ye, Jun; Chen, Yanmin; Wang, Tingting; Gao, Lili; Liu, Yuling; Yang, Yanfang] Chinese Acad Med Sci & Peking Union Med Coll, Inst Mat Med, Beijing Key Lab Drug Delivery Technol & Novel Form, Beijing 100050, Peoples R China.
C3 Chinese Academy of Medical Sciences - Peking Union Medical College;
   Peking Union Medical College; Chinese Academy of Medical Sciences -
   Peking Union Medical College; Peking Union Medical College
RP Liu, YL; Yang, YF (corresponding author), Chinese Acad Med Sci & Peking Union Med Coll, State Key Lab Bioact Subst & Funct Nat Med, Inst Mat Med, Beijing 100050, Peoples R China.
EM ylliu@imm.ac.cn; yangyf@imm.ac.cn
RI Wang, Tingting/ADX-2486-2022; Chen, YM/A-9992-2011
FU CAMS Inno-vation Fund for Medical Sciences (CIFMS) [2021-I2M-1-026];
   Beijing Natural Science Foundation of China [7212155, 7162135]
FX <B>Acknowledgments</B> This work was supported by the grants from the
   CAMS Inno-vation Fund for Medical Sciences (CIFMS) (Grant No.:
   2021-I2M-1-026) and the Beijing Natural Science Foundation of China
   (Grant Nos.: 7212155 and 7162135) .
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PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2095-1779
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J9 J PHARM ANAL
JI J. Pharm. Anal.
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PY 2024
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WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA D7Y6O
UT WOS:001298306400001
PM 38799237
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Lundberg, JO
   Carlström, M
   Larsen, FJ
   Weitzberg, E
AF Lundberg, Jon O.
   Carlstrom, Mattias
   Larsen, Filip J.
   Weitzberg, Eddie
TI Roles of dietary inorganic nitrate in cardiovascular health and disease
SO CARDIOVASCULAR RESEARCH
LA English
DT Review
DE Nitrite; Nitric oxide; S-Nitrosothiol; DASH; Type 2 diabetes
ID VIVO ISCHEMIA-REPERFUSION; NITRIC-OXIDE PRODUCTION;
   CYTOCHROME-C-OXIDASE; MUCOSAL BLOOD-FLOW; IN-VIVO; ISCHEMIA/REPERFUSION
   INJURY; METABOLIC SYNDROME; VEGETABLE INTAKE; PLASMA NITRITE; NO
   GENERATION
AB Inorganic nitrate from dietary and endogenous sources is emerging as a substrate for in vivo generation of nitric oxide (NO) and other reactive nitrogen oxides. Dietary amounts of nitrate clearly have robust NO-like effects in humans, including blood pressure reduction, inhibition of platelet aggregation, and vasoprotective activity. In animal models, nitrate protects against ischaemia-reperfusion injuries and several other types of cardiovascular disorders. In addition, nitrate most surprisingly decreases whole body oxygen cost during exercise with preserved or even enhanced maximal performance. Oxidative stress and reduced NO bioavailability are critically linked to development of hypertension and other forms of cardiovascular diseases. Mechanistically, a central target for the effects of nitrate and its reaction products seems to be the mitochondrion and modulation of oxidative stress. All in vivo effects of nitrate are achievable with amounts corresponding to a rich intake of vegetables, which are particularly rich in this anion. A theory is now emerging suggesting nitrate as an active component in vegetables contributing to the beneficial health effects of this food group, including protection against cardiovascular disease and type-2 diabetes.
C1 [Lundberg, Jon O.; Carlstrom, Mattias; Larsen, Filip J.; Weitzberg, Eddie] Karolinska Inst, Dept Physiol & Pharmacol, S-17177 Stockholm, Sweden.
   [Carlstrom, Mattias] Uppsala Univ, Div Integrat Physiol, Dept Med Cell Biol, S-75123 Uppsala, Sweden.
C3 Karolinska Institutet; Uppsala University
RP Lundberg, JO (corresponding author), Karolinska Inst, Dept Physiol & Pharmacol, S-17177 Stockholm, Sweden.
EM jon.lundberg@ki.se
RI Carlstrom, Mattias/E-7350-2015
OI Carlstrom, Mattias/0000-0001-9923-8729; Lundberg,
   Jon/0000-0002-0174-5210
FU EU; Vinnova (CIDaT); Swedish Heart and Lung Foundation; Swedish Research
   Council; Torsten and Ragnar Soderbergs Foundation; Wenner-Gren
   Foundation; Swedish Society of Medicine; Swedish Society for Medical
   Research (SSMF); Stockholm City Council (ALF); Karolinska Institutet
FX Generous support was received from EUs 7<SUP>th</SUP> Framework Program
   (Flaviola), Vinnova (CIDaT), the Swedish Heart and Lung Foundation, The
   Swedish Research Council, Torsten and Ragnar Soderbergs Foundation, The
   Wenner-Gren Foundation, The Swedish Society of Medicine, The Swedish
   Society for Medical Research (SSMF), The Swedish Research Council,
   Stockholm City Council (ALF), and Karolinska Institutet.
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WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 712OT
UT WOS:000286676800009
PM 20937740
OA Bronze
DA 2025-06-11
ER

PT J
AU Lam-Sidun, D
   Peters, KM
   Borradaile, NM
AF Lam-Sidun, Daniel
   Peters, Kia M.
   Borradaile, Nica M.
TI Mushroom-Derived Medicine? Preclinical Studies Suggest Potential
   Benefits of Ergothioneine for Cardiometabolic Health
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE mushrooms; ergothioneine; antioxidant; anti-inflammatory; type 2
   diabetes; metabolic syndrome; cardiovascular disease
AB Medicinal use of mushrooms has been documented since ancient times, and in the modern world, mushrooms have a longstanding history of use in Eastern medicine. Recent interest in plant-based diets in Westernized countries has brought increasing attention to the use of mushrooms and mushroom-derived compounds in the prevention and treatment of chronic diseases. Edible mushrooms are the most abundant food sources of the modified amino acid, ergothioneine. This compound has been shown to accumulate in almost all cells and tissues, but preferentially in those exposed to oxidative stress and injury. The demonstrated cytoprotectant effect of ergothioneine has led many to suggest a potential therapeutic role for this compound in chronic conditions that involve ongoing oxidative stress and inflammation, including cardiovascular and metabolic diseases. However, the in vivo effects of ergothioneine and its underlying therapeutic mechanisms in the whole organism are not as clear. Moreover, there are no well-defined, clinical prevention and intervention trials of ergothioneine in chronic disease. This review highlights the cellular and molecular mechanisms of action of ergothioneine and its potential as a Traditional, Complementary and Alternative Medicine for the promotion of cardiometabolic health and the management of the most common manifestations of cardiometabolic disease.
C1 [Lam-Sidun, Daniel; Peters, Kia M.; Borradaile, Nica M.] Western Univ, Dept Physiol & Pharmacol, Schulich Sch Med & Dent, London, ON N6A 5C1, Canada.
C3 Western University (University of Western Ontario)
RP Borradaile, NM (corresponding author), Western Univ, Dept Physiol & Pharmacol, Schulich Sch Med & Dent, London, ON N6A 5C1, Canada.
EM dlamsidu@uwo.ca; kpeter44@uwo.ca; nica.borradaile@schulich.uwo.ca
OI Borradaile, Nica/0000-0001-6677-2175
FU Agriculture and Agri-food Canada, Canadian Agricultural Partnership [CAP
   0049]; Mushrooms Canada; Canada Graduate Scholarship-Master's; Ontario
   Graduate Scholarship
FX Support was provided by an Agriculture and Agri-food Canada, Canadian
   Agricultural Partnership, grant number CAP 0049 to N.M.B. The
   Agricultural Adaptation Council assisted in the delivery of CAP in
   Ontario. CAP collaborative partnership funding was provided by Mushrooms
   Canada (www.mushrooms.ca).D.L.-S.was supported by a Canada Graduate
   Scholarship-Master's and K.M.P. was supported by an Ontario Graduate
   Scholarship.
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NR 64
TC 22
Z9 27
U1 11
U2 50
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD MAR
PY 2021
VL 22
IS 6
AR 3246
DI 10.3390/ijms22063246
PG 11
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA RV4IM
UT WOS:000645798500001
PM 33806754
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Bouazza, A
   Fontaine, E
   Leverve, X
   Koceir, EA
AF Bouazza, Asma
   Fontaine, Eric
   Leverve, Xavier
   Koceir, Elhadj-Ahmed
TI Interference of altered plasma trace elements profile with
   hyperhomocysteinemia and oxidative stress damage to insulin secretion
   dysfunction in Psammomys obesus: focus on the selenium
SO ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
LA English
DT Article
DE Selenium; hyperhomocysteine; type 2 diabetes mellitus; oxidative stress;
   Psammomys obesus
ID HIGH-FAT-DIET; SUPEROXIDE-DISMUTASE; HOMOCYSTEINE LEVELS;
   GLUTATHIONE-PEROXIDASE; METABOLIC SYNDROME; PANCREATIC-ISLETS;
   ENDOTHELIAL DYSFUNCTION; ANTIOXIDANT ACTIVITY; LIPID-PEROXIDATION;
   GLUCOSE-METABOLISM
AB The objective of this study is to investigate the relationship between altered plasma trace elements, particularly selenium (Se), with Hyper-homocysteinemia (HhCys) as a predictive factor of insulin secretion dysfunction. The study is carried out on adult Psammomys obesus, divided in 4 experimental groups: (I) Normoglycemic/Normoinsulinemic; (II) Normoglycemic/Hyperinsulinemic; (III) Hyperglycaemic/Hyperinsulinemic and (IV) Hyperglycaemic/Insulin deficiency with ketoacidosis. The data showed that a drastic depletion of Se plasma levels is positively correlated with HhCys (>15 mu mol/L; p < .001), concomitantly with decreased GPx activity, GSH levels, and GSH/GSSG ratio in group IV both in plasma and liver. In contrast, SOD activity is increased (p <= .001) in group IV both in plasma and liver. However, plasma Cu and Mn levels increased, while plasma Zn levels decreased in group IV (p < .001). Our study confirms the increase of plasma hCys levels seemed to be a major contributing factor to antioxidant capacities and alters the availability of selenium metabolism by interference with homocysteine synthesis in the insulin secretion deficiency stage.
C1 [Bouazza, Asma; Koceir, Elhadj-Ahmed] Univ Sci & Technol Houari Boumed USTHB, Fac Biol Sci, Lab Biol & Organism Physiol, Bioenerget & Intermediary Metab Team, Algiers, Algeria.
   [Fontaine, Eric; Leverve, Xavier] INSERM, Lab Bioenerget Fondamentale & Appliquee LBFA, Grenoble, France.
C3 University Science & Technology Houari Boumediene; Institut National de
   la Sante et de la Recherche Medicale (Inserm)
RP Koceir, EA (corresponding author), Univ Sci & Technol Houari Boumed USTHB, Fac Biol Sci, Lab Biol & Organism Physiol Biol, BP 32, Algiers 16123, Algeria.
EM e.koceir@gmail.com
OI KOCEIR, Elhadj-Ahmed/0000-0003-1345-2535
FU Algerian Agency for the Research & Development in Health [208/ANDRS,
   41/ANDRS/2011]; Algerian Ministry of Higher Education Program [F 0022014
   0100]
FX The authors would like to acknowledge the financial support of the
   Algerian Agency for the Research & Development in Health (PNR No.
   208/ANDRS and PNR No.41/ANDRS/2011) and the Algerian Ministry of Higher
   Education Program (No. F 0022014
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NR 103
TC 0
Z9 0
U1 0
U2 3
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1381-3455
EI 1744-4160
J9 ARCH PHYSIOL BIOCHEM
JI Arch. Physiol. Biochem.
PD MAR 4
PY 2023
VL 129
IS 2
BP 505
EP 518
DI 10.1080/13813455.2020.1839501
EA NOV 2020
PG 14
WC Biochemistry & Molecular Biology; Biophysics; Endocrinology &
   Metabolism; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Endocrinology &
   Metabolism; Physiology
GA A3VJ1
UT WOS:000588188100001
PM 33171059
DA 2025-06-11
ER

PT J
AU Elrashidy, RA
   Zhang, J
   Liu, GM
AF Elrashidy, Rania A.
   Zhang, Jing
   Liu, Guiming
TI Long-term consumption of Western diet contributes to endothelial
   dysfunction and aortic remodeling in rats: Implication of Rho-kinase
   signaling
SO CLINICAL AND EXPERIMENTAL HYPERTENSION
LA English
DT Article
DE Aortic remodeling; endothelial dysfunction; endothelial nitric oxide
   synthase; Rho kinase; Western diet
ID HIGH-FRUCTOSE; HIGH-FAT; OXIDATIVE STRESS; NITRIC-OXIDE; INHIBITION;
   ACTIVATION; HYPERTENSION; INVOLVEMENT; METABOLISM; COMPONENTS
AB Western diet (WD), rich in saturated fat and sugars, has become a risk factor for obesity and metabolic syndrome, however, its effect on endothelial function and vascular remodeling is not fully elucidated. Recent evidence suggests cross-talk between Rho kinase (ROCK) pathway and cardiovascular system. We aimed to investigate the effect of WD on aortic remodeling and the contribution of ROCK signaling. Eight week old male Sprague-Dawley rats were fed either standard chow diet (SD) or high fructose/ high-fat diet, typically as in WD. After 42 weeks, WD-fed rats showed hyperglycemia, dyslipidemia, and hypertension without marked weight gain, compared to SD-fed rats. Significant up-regulation of ROCK-1 and -2, along with a decline in eNOS expression were found in the aortic tissue of WD-fed rats. Additionally, WD-fed rats displayed oxidative stress and fibrosis in their aortic tissues versus controls. Our findings suggest that long-term feeding of WD contributes to endothelial dysfunction and aortic remodeling in adult male rats. ROCK activation seems to be involved in WD-related vascular disorders and may represent a promising therapeutic target.
C1 [Elrashidy, Rania A.; Liu, Guiming] Case Western Reserve Univ, Dept Surg, MetroHlth Med Ctr, Cleveland, OH 44106 USA.
   [Elrashidy, Rania A.] Zagazig Univ, Dept Biochem, Fac Pharm, Zagazig 44519, Egypt.
   [Zhang, Jing] Capital Med Univ, Dept Hyperbar Oxygen, Beijing Chao Yang Hosp, Beijing, Peoples R China.
C3 University System of Ohio; Case Western Reserve University; MetroHealth
   System; Egyptian Knowledge Bank (EKB); Zagazig University; Capital
   Medical University
RP Elrashidy, RA (corresponding author), Case Western Reserve Univ, Dept Surg, MetroHlth Med Ctr, Cleveland, OH 44106 USA.; Elrashidy, RA (corresponding author), Zagazig Univ, Dept Biochem, Fac Pharm, Zagazig 44519, Egypt.
EM ra_elrashidy@yahoo.com
RI Elrashidy, Rania/HLW-2856-2023; Liu, Guiming/AAM-2688-2020
OI Elrashidy, Rania/0000-0001-8383-8383
FU NIDDK NIH HHS [R01 DK110567] Funding Source: Medline
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NR 41
TC 13
Z9 13
U1 0
U2 21
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1064-1963
EI 1525-6006
J9 CLIN EXP HYPERTENS
JI Clin. Exp. Hypertens.
PD FEB 17
PY 2019
VL 41
IS 2
BP 174
EP 180
DI 10.1080/10641963.2018.1462375
PG 7
WC Pharmacology & Pharmacy; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Cardiovascular System & Cardiology
GA HG3ZN
UT WOS:000454914000011
PM 29667441
DA 2025-06-11
ER

PT J
AU Ress, C
   Kaser, S
AF Ress, Claudia
   Kaser, Susanne
TI Mechanisms of intrahepatic triglyceride accumulation
SO WORLD JOURNAL OF GASTROENTEROLOGY
LA English
DT Review
DE Steatosis; Lipid accumulation; Fatty acids; Insulin resistance;
   Triglycerides
ID NONALCOHOLIC FATTY LIVER; HEPATITIS-C VIRUS; ACTIVATED RECEPTOR-ALPHA;
   MUSCLE INSULIN-RESISTANCE; ENDOPLASMIC-RETICULUM STRESS; TERM-FOLLOW-UP;
   SEVERE LIPODYSTROPHY; GLUCOSE-HOMEOSTASIS; METABOLIC SYNDROME; OXIDATIVE
   STRESS
AB Hepatic steatosis defined as lipid accumulation in hepatocytes is very frequently found in adults and obese adolescents in the Western World. Etiologically, obesity and associated insulin resistance or excess alcohol intake are the most frequent causes of hepatic steatosis. However, steatosis also often occurs with chronic hepatitis C virus (HCV) infection and is also found in rare but potentially life-threatening liver diseases of pregnancy. Clinical significance and outcome of hepatic triglyceride accumulation are highly dependent on etiology and histological pattern of steatosis. This review summarizes current concepts of pathophysiology of common causes of hepatic steatosis, including non-alcoholic fatty liver disease (NAFLD), alcoholic fatty liver disease, chronic HCV infections, drug-induced forms of hepatic steatosis, and acute fatty liver of pregnancy. Regarding the pathophysiology of NAFLD, this work focuses on the close correlation between insulin resistance and hepatic triglyceride accumulation, highlighting the potential harmful effects of systemic insulin resistance on hepatic metabolism of fatty acids on the one side and the role of lipid intermediates on insulin signalling on the other side. Current studies on lipid droplet morphogenesis have identified novel candidate proteins and enzymes in NAFLD.
C1 [Ress, Claudia; Kaser, Susanne] Med Univ Innsbruck, Dept Internal Med 1, A-6020 Innsbruck, Austria.
   [Ress, Claudia; Kaser, Susanne] Med Univ Innsbruck, Dept Internal Med 1, Christian Doppler Lab Metab Crosstalk, Anichstr 35, A-6020 Innsbruck, Austria.
C3 Medical University of Innsbruck; Medical University of Innsbruck
RP Kaser, S (corresponding author), Med Univ Innsbruck, Dept Internal Med 1, Christian Doppler Lab Metab Crosstalk, Anichstr 35, A-6020 Innsbruck, Austria.
EM susanne.kaser@i-med.ac.at
RI Kaser, Susanne/JEO-6334-2023
OI Kaser, Susanne/0000-0003-2524-5218
FU Austrian Federal Ministry of Science, Research and Economy; National
   Foundation for Research, Technology and Development
FX Supported by Austrian Federal Ministry of Science, Research and Economy
   and the National Foundation for Research, Technology and Development.
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NR 123
TC 88
Z9 98
U1 3
U2 33
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 8226 REGENCY DR, PLEASANTON, CA 94588 USA
SN 1007-9327
EI 2219-2840
J9 WORLD J GASTROENTERO
JI World J. Gastroenterol.
PD JAN 28
PY 2016
VL 22
IS 4
BP 1664
EP 1673
DI 10.3748/wjg.v22.i4.1664
PG 10
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA DB5KF
UT WOS:000368552300030
PM 26819531
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Kasprzak-Drozd, K
   Nizinski, P
   Kasprzak, P
   Kondracka, A
   Oniszczuk, T
   Rusinek, A
   Oniszczuk, A
AF Kasprzak-Drozd, Kamila
   Nizinski, Przemyslaw
   Kasprzak, Paulina
   Kondracka, Adrianna
   Oniszczuk, Tomasz
   Rusinek, Agata
   Oniszczuk, Anna
TI Does Resveratrol Improve Metabolic Dysfunction-Associated Steatotic
   Liver Disease (MASLD)?
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE resveratrol; MASLD; polyphenols; nutraceuticals; metabolic syndrome;
   functional food; lipids; oxidative stress; antioxidants
ID FATTY LIVER; INSULIN-RESISTANCE; PHYTOALEXIN RESVERATROL; HEPATIC
   STEATOSIS; LIPID-METABOLISM; DIET; NAFLD; ACID; MICE; SUPPLEMENTATION
AB Metabolic dysfunction-associated steatotic liver disease (MASLD) is influenced by a variety of factors, including environmental and genetic factors. The most significant outcome is the alteration of free fatty acid and triglyceride metabolism. Lipotoxicity, impaired autophagy, chronic inflammation, and oxidative stress, as well as coexisting insulin resistance, obesity, and changes in the composition of gut microbiota, are also considered crucial factors in the pathogenesis of MASLD. Resveratrol is a polyphenolic compound that belongs to the stilbene subgroup. This review summarises the available information on the therapeutic effects of resveratrol against MASLD. Resveratrol has demonstrated promising antisteatotic, antioxidant, and anti-inflammatory activities in liver cells in in vitro and animal studies. Resveratrol has been associated with inhibiting the NF-kappa B pathway, activating the SIRT-1 and AMPK pathways, normalizing the intestinal microbiome, and alleviating intestinal inflammation. However, clinical studies have yielded inconclusive results regarding the efficacy of resveratrol in alleviating hepatic steatosis or reducing any of the parameters found in MASLD in human patients. The lack of homogeneity between studies, low bioavailability of resveratrol, and population variability when compared to animal models could be the reasons for this.
C1 [Kasprzak-Drozd, Kamila; Rusinek, Agata; Oniszczuk, Anna] Med Univ Lublin, Dept Inorgan Chem, Chodzki 4a, PL-20093 Lublin, Poland.
   [Nizinski, Przemyslaw] Med Univ Lublin, Dept Pharmacol, Radziwillowska 11, PL-20080 Lublin, Poland.
   [Kasprzak, Paulina] Med Univ Lublin, Dept Conservat Dent Endodont, Chodzki 6, PL-20093 Lublin, Poland.
   [Kondracka, Adrianna] Med Univ Lublin, Dept Obstet & Pathol Pregnancy, Staszica 16, PL-20081 Lublin, Poland.
   [Oniszczuk, Tomasz] Univ Life Sci Lublin, Dept Thermal Technol & Food Proc Engn, Gleboka 31, PL-20612 Lublin, Poland.
C3 Medical University of Lublin; Medical University of Lublin; Medical
   University of Lublin; Medical University of Lublin; University of Life
   Sciences in Lublin
RP Oniszczuk, A (corresponding author), Med Univ Lublin, Dept Inorgan Chem, Chodzki 4a, PL-20093 Lublin, Poland.
EM kamilakasprzakdrozd@umlub.pl; przemyslaw.nizinski@umlub.pl;
   paulina.kasprzak87@gmail.com; adriannnakondracka@umlub.pl;
   tomasz.oniszczuk@up.lublin.pl; agatarusinek997@gmail.com;
   annaoniszczuk@umlub.pl
RI Oniszczuk, Anna/A-2397-2019; Nizinski, Przemyslaw/JDT-1955-2023;
   Oniszczuk, Tomasz/Z-1941-2018
OI Oniszczuk, Anna/0000-0002-5109-3302; Nizinski,
   Przemyslaw/0000-0003-1724-0089; Oniszczuk, Tomasz/0000-0002-1061-6541;
   Kasprzak-Drozd, Kamila/0000-0002-6282-6313
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NR 126
TC 16
Z9 16
U1 9
U2 18
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD APR
PY 2024
VL 25
IS 7
AR 3746
DI 10.3390/ijms25073746
PG 21
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA NN4V8
UT WOS:001201126300001
PM 38612556
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Chen, TT
   Xiao, F
   Li, N
   Shan, S
   Qi, M
   Wang, ZY
   Zhang, SN
   Wei, W
   Sun, WY
AF Chen, Ting-Ting
   Xiao, Feng
   Li, Nan
   Shan, Shan
   Qi, Meng
   Wang, Zi-Ying
   Zhang, Sheng-Nan
   Wei, Wei
   Sun, Wu-Yi
TI Inflammasome as an Effective Platform for Fibrosis Therapy
SO JOURNAL OF INFLAMMATION RESEARCH
LA English
DT Review
DE inflammasome; fibrosis; NLRP3; AIM2; caspase-1
ID HEPATIC STELLATE CELLS; NF-KAPPA-B; MESENCHYMAL TRANSITION EMT; INDUCED
   LUNG INFLAMMATION; NLRP3 INFLAMMASOME; AIM2 INFLAMMASOME; OXIDATIVE
   STRESS; LIVER FIBROSIS; CASPASE-1 AUTOPROTEOLYSIS; SYSTEMIC-SCLEROSIS
AB Fibrosis is the final stage of the development of chronic inflammation. It is characterized by excessive deposition of the extracellular matrix, leading to tissue structure damage and organ dysfunction, which is a serious threat to human health and life. However, the molecular mechanism of fibrosis is still unclear. Inflammasome is a molecular complex of proteins that has been becoming a key innate sensor for host immunity and is involved in pyroptosis, pathogen infection, metabolic syndrome, cellular stress, and tumor metastasis. Inflammasome signaling and downstream cytokine responses mediated by the inflammasome have been found to play an important role in fibrosis. The inflammasome regulates the secretion of IL-1 beta and IL-18, which are both critical for the process of fibrosis. Recently, researches on the function of inflammasome have attracted extensive attention, and data derived from these researches have increased our understanding of the effects and regulation of inflammasome during fibrosis. In this review, we emphasize the growing evidence for both indirect and direct effects of inflammasomes in triggering fibrosis as well as potential novel targets for antifibrotic therapies.
C1 [Chen, Ting-Ting; Xiao, Feng; Li, Nan; Shan, Shan; Qi, Meng; Wang, Zi-Ying; Zhang, Sheng-Nan; Wei, Wei; Sun, Wu-Yi] Anhui Med Univ, Inst Clin Pharmacol, Key Lab Antiinflammatory & Immune Med, Minist Educ,Anhui Collaborat Innovat Ctr Antiinfl, 81 Meishan Rd, Hefei 230032, Anhui, Peoples R China.
C3 Ministry of Education - China; Anhui Medical University
RP Wei, W; Sun, WY (corresponding author), Anhui Med Univ, Inst Clin Pharmacol, Key Lab Antiinflammatory & Immune Med, Minist Educ,Anhui Collaborat Innovat Ctr Antiinfl, 81 Meishan Rd, Hefei 230032, Anhui, Peoples R China.
EM wwei@ahmu.edu.cn; sunwuyi51@aliyun.com
RI shan, shan/JUU-8486-2023; Yan, Ying/AAU-9853-2021; wei,
   wei/HHR-8613-2022; Sun, Wuyi/AAM-7757-2020; Qi, Meng/AAR-5666-2021;
   Chen, Tingting/JQI-2433-2023
FU National Natural Science Foundation of China [81770605]; Program for
   Young Excellent Talents in Universities of Anhui Province
   [gxyqZD2018024]
FX This work was supported by grants from the National Natural Science
   Foundation of China (No. 81770605), Program for Young Excellent Talents
   in Universities of Anhui Province (No. gxyqZD2018024).
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NR 142
TC 11
Z9 14
U1 0
U2 11
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
EI 1178-7031
J9 J INFLAMM RES
JI J. Inflamm. Res.
PY 2021
VL 14
BP 1575
EP 1590
DI 10.2147/JIR.S304180
PG 16
WC Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology
GA RP0MX
UT WOS:000641432200001
PM 33907438
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Senesi, P
   Montesano, A
   Luzi, L
   Codella, R
   Benedini, S
   Terruzzi, I
AF Senesi, Pamela
   Montesano, Anna
   Luzi, Livio
   Codella, Roberto
   Benedini, Stefano
   Terruzzi, Ileana
TI Metformin Treatment Prevents Sedentariness Related Damages in Mice
SO JOURNAL OF DIABETES RESEARCH
LA English
DT Article
ID INSULIN-RESISTANCE; NUTRITIONAL INTERVENTIONS; SIGNALING PATHWAYS;
   METABOLIC SYNDROME; OXIDATIVE STRESS; EXERCISE; HYPERTROPHY; MYOGENESIS;
   PHOSPHORYLATION; PERSPECTIVE
AB Metformin (METF), historical antihyperglycemic drug, is a likely candidate for lifespan extension, treatment and prevention of sedentariness damages, insulin resistance, and obesity. Skeletal muscle is a highly adaptable tissue, capable of hypertrophy response to resistance training and of regeneration after damage. Aims of this work were to investigate METF ability to prevent sedentariness damage and to enhance skeletal muscle function. Sedentary 12-week-old C57BL/6 mice were treated with METF(250 mg/kg per day, in drinking water) for 60 days. METF role on skeletal muscle differentiation was studied in vitro using murine C2C12 myoblasts. Muscular performance evaluation revealed that METF enhanced mice physical performance (Estimated VO2max). Biochemical analyses of hepatic and muscular tissues indicated that in liver METF increased AMPK and CAMKII signaling. In contrast, METF inactivated ERKs, the principal kinases involved in hepatic stress. In skeletal muscle, METF activated AKT, key kinase in skeletal muscle mass maintenance. In in vitro studies, METF did not modify the C2C12 proliferation capacity, while it positively influenced the differentiation process and myotube maturation. In conclusion, our novel results suggest that METF has a positive action not only on the promotion of healthy aging but also on the prevention of sedentariness damages.
C1 [Senesi, Pamela; Montesano, Anna; Luzi, Livio; Codella, Roberto; Benedini, Stefano] Univ Milan, Dept Biomed Sci Hlth, Milan, Italy.
   [Senesi, Pamela; Luzi, Livio; Codella, Roberto; Benedini, Stefano] San Donato Hosp & Sci Inst, Metab Res Ctr, Milan, Italy.
   [Terruzzi, Ileana] Ist Sci San Raffaele, Diabet Res Inst, Metab Nutrigen & Cellular Differentiat Unit, I-20132 Milan, Italy.
C3 University of Milan; IRCCS Policlinico San Donato; Vita-Salute San
   Raffaele University; IRCCS Ospedale San Raffaele
RP Terruzzi, I (corresponding author), Ist Sci San Raffaele, Diabet Res Inst, Metab Nutrigen & Cellular Differentiat Unit, I-20132 Milan, Italy.
EM terruzzi.ileana@hsr.it
RI Codella, Roberto/L-4460-2016; Senesi, Pamela/AAA-5678-2019; Benedini,
   Stefano/F-7483-2013; Terruzzi, Ileana/AAA-9737-2019; Luzi,
   Livio/M-2696-2016
OI Codella, Roberto/0000-0003-1608-1899; Terruzzi,
   Ileana/0000-0002-8663-4033; Luzi, Livio/0000-0003-3183-0552; Montesano,
   Anna/0000-0001-9129-5374; Senesi, Pamela/0000-0003-0304-1564
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NR 39
TC 29
Z9 32
U1 0
U2 12
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2314-6745
EI 2314-6753
J9 J DIABETES RES
JI J. Diabetes Res.
PY 2016
VL 2016
AR 8274689
DI 10.1155/2016/8274689
PG 11
WC Endocrinology & Metabolism; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Research & Experimental Medicine
GA DG7ES
UT WOS:000372248200001
PM 26697506
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Czarzasta, K
   Pojoga, LH
AF Czarzasta, Katarzyna
   Pojoga, Luminita H.
TI Interplay between caveolin-1 and mineralocorticoid receptor in
   cardiometabolic disease
SO JOURNAL OF ENDOCRINOLOGY
LA English
DT Review
DE cardiovascular; caveolin-1; metabolic; mineralocorticoid receptor
ID NITRIC-OXIDE SYNTHASE; SELECTIVE ALDOSTERONE BLOCKER; WIDE LINKAGE SCAN;
   METABOLIC SYNDROME; INSULIN-RECEPTOR; ANGIOTENSIN-II; BLOOD-PRESSURE;
   MICROVASCULAR PERMEABILITY; ENDOTHELIAL CAVEOLIN-1; RESISTANT
   HYPERTENSION
AB Over the past decades, research has clearly established the important role of the mineralocorticoid receptor (MR) in both renal and extra-renal tissues. Recently, caveolin-1 (Cav-1) has emerged as a mediator of MR signaling in several tissues, with implications on cardiovascular and metabolic dysfunction. The main structural component of caveolae (plasma membrane invaginations with diverse functions), Cav-1 is a modulator of cardiovascular function, cellular glucose, and lipid homeostasis, via its effects on signal transduction pathways that mediate inflammatory responses and oxidative stress. In this review, we present evidence indicating an overlap between the roles of the MR and Cav-1 in cardiometabolic disease and the relevant signaling pathways involved. Furthermore, we discuss the potential use of Cav-1 as a biomarker and/or target for MR-mediated dysfunction.
C1 [Czarzasta, Katarzyna] Med Univ Warsaw, Lab Ctr Preclin Res, Dept Expt & Clin Physiol, Warsaw, Poland.
   [Pojoga, Luminita H.] Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Div Endocrinol Diabet & Hypertens, Boston, MA 02115 USA.
C3 Medical University of Warsaw; Harvard University; Harvard Medical
   School; Harvard University Medical Affiliates; Brigham & Women's
   Hospital
RP Pojoga, LH (corresponding author), Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Div Endocrinol Diabet & Hypertens, Boston, MA 02115 USA.
EM lpojoga@bwh.harvard.edu
OI Czarzasta, Katarzyna/0000-0002-9836-9409
FU National Heart, Lung, and Blood Institute at the National Institutes of
   Health [R01-HL104032, R56-HL166263]; Polish National Agency for Academic
   Exchange (NAWA) [PPN/WAL/2019/1/00010]
FX This work was supported by the National Heart, Lung, and Blood Institute
   at the National Institutes of Health, (grant nos R01-HL104032 and
   R56-HL166263 (LHP)), and by the Polish National Agency for Academic
   Exchange (NAWA) (grant no. PPN/WAL/2019/1/00010 (KC)).
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NR 147
TC 0
Z9 0
U1 1
U2 1
PU BIOSCIENTIFICA LTD
PI BRISTOL
PA STARLING HOUSE, 1600 BRISTOL PARKWAY N, BRISTOL, ENGLAND
SN 0022-0795
EI 1479-6805
J9 J ENDOCRINOL
JI J. Endocrinol.
PD SEP 1
PY 2024
VL 262
IS 3
AR e230341
DI 10.1530/JOE-23-0341
PG 13
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA Q2D1M
UT WOS:001382845200006
PM 38916410
DA 2025-06-11
ER

PT J
AU Mayoral, LPC
   Matias-Cervantes, CA
   Pérez-Campos, E
   Díaz, CR
   Barrios, LAL
   Canseco, MDP
   Cruz, MM
   Mayoral, EPC
   Mata, CJS
   Canales, FJR
   Ruíz, HM
   Hernández-Huerta, MT
AF Perez-Campos Mayoral, Laura
   Matias-Cervantes, Carlos Alberto
   Perez-Campos, Eduardo
   Romero Diaz, Carlos
   Laguna Barrios, Luis Angel
   Pina Canseco, Maria del Socorro
   Martinez Cruz, Margarito
   Perez-Campos Mayoral, Eduardo
   Solorzano Mata, Carlos Josue
   Rodal Canales, Francisco Javier
   Martinez Ruiz, Hector
   Hernandez-Huerta, Maria Teresa
TI Associations of Dynapenic Obesity and Sarcopenic Obesity with the Risk
   of Complications in COVID-19
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE sarcopenic obesity; ageing; COVID-19; complications; dynapenic obesity
ID RENIN-ANGIOTENSIN SYSTEM; CARDIOVASCULAR-DISEASE; INSULIN-RESISTANCE;
   ADIPOSE-TISSUE; SKELETAL-MUSCLE; CORONAVIRUS DISEASE; INTERNATIONAL
   UNION; NUTRITIONAL-STATUS; METABOLIC SYNDROME; CROSS-TALK
AB Ageing is associated with changes in body composition, such as low muscle mass (sarcopenia), decreased grip strength or physical function (dynapenia), and accumulation of fat mass. When the accumulation of fat mass synergistically accompanies low muscle mass or reduced grip strength, it results in sarcopenic obesity and dynapenic obesity, respectively. These types of obesity contribute to the increased risk of cardiovascular disease and mortality in the elderly, which could increase the damage caused by COVID-19. In this review, we associated factors that could generate a higher risk of COVID-19 complications in dynapenic obesity and sarcopenic obesity. For example, skeletal muscle regulates the expression of inflammatory cytokines and supports metabolic stress in pulmonary disease; hence, the presence of dynapenic obesity or sarcopenic obesity could be related to a poor prognosis in COVID-19 patients.
C1 [Perez-Campos Mayoral, Laura; Laguna Barrios, Luis Angel; Pina Canseco, Maria del Socorro; Perez-Campos Mayoral, Eduardo; Solorzano Mata, Carlos Josue; Rodal Canales, Francisco Javier; Martinez Ruiz, Hector] Univ Autonoma Benito Juarez Oaxaca, Ctr Invest, Fac Med, Fac Med & Cirug,UNAM UABJO, Oaxaca 68020, Oaxaca, Mexico.
   [Matias-Cervantes, Carlos Alberto; Romero Diaz, Carlos; Hernandez-Huerta, Maria Teresa] Univ Autonoma Benito Juarez Oaxaca, CONACyT, Fac Med & Cirug, Oaxaca 68020, Oaxaca, Mexico.
   [Perez-Campos, Eduardo; Martinez Cruz, Margarito] Tecnol Nacl Mexico IT Oaxaca, Oaxaca 68030, Oaxaca, Mexico.
   [Solorzano Mata, Carlos Josue] Univ Autonoma Benito Juarez Oaxaca, Fac Odontol, Oaxaca 68120, Oaxaca, Mexico.
C3 Universidad Nacional Autonoma de Mexico; Universidad Autonoma Benito
   Juarez de Oaxaca; Consejo Nacional de Ciencia y Tecnologia (CONACyT);
   Universidad Autonoma Benito Juarez de Oaxaca; Universidad Autonoma
   Benito Juarez de Oaxaca
RP Hernández-Huerta, MT (corresponding author), Univ Autonoma Benito Juarez Oaxaca, CONACyT, Fac Med & Cirug, Oaxaca 68020, Oaxaca, Mexico.; Pérez-Campos, E (corresponding author), Tecnol Nacl Mexico IT Oaxaca, Oaxaca 68030, Oaxaca, Mexico.
EM laupcm9@gmail.com; carloscervantes.ox@outlook.com;
   perezcampos@prodigy.net.mx; carlos.rom.74he@gmail.com;
   lalb2906@gmail.com; socopina12@hotmail.com; martinezcu9@hotmail.com;
   epcm@live.com.mx; universidad99@hotmail.com; rrodal22@gmail.com;
   drheccctor@hotmail.com; marte-hh28@hotmail.com
RI HUERTA, MARIA/AAS-1192-2020; Perez-Campos, Eduardo/AAH-1263-2019;
   Perez-Campos, Eduardo/D-6596-2018; Solorzano-Mata, Carlos
   Josue/G-5260-2019; MARTINEZ RUIZ, HECTOR/HNB-9592-2023; Perez-Campos
   Mayoral, Laura/G-2014-2018
OI Matias Cervantes, Carlos Alberto/0000-0002-3476-1743; Perez-Campos,
   Eduardo/0000-0001-6720-7952; Solorzano-Mata, Carlos
   Josue/0000-0002-5735-0373; MARTINEZ RUIZ, HECTOR/0000-0003-2508-4194;
   Laguna Barrios, Luis Angel/0000-0002-1710-0679; Perez-Campos Mayoral,
   Laura/0000-0003-4140-4661; HERNANDEZ HUERTA, MARIA
   TERESA/0000-0003-2182-2540; /0000-0002-9486-5093; Perez Campos Mayoral,
   Eduardo/0000-0002-6032-7609
FU UABJO Faculty of Medicine, Oaxaca, Mexico; National Institute of
   Technology in Mexico (TecNM); CONACYT
   [CONACYT-BP-PA-20210507234900732-959110, 745683]
FX This work was supported by the UABJO Faculty of Medicine, Oaxaca, Mexico
   and National Institute of Technology in Mexico (TecNM), and also CONACYT
   (CONACYT-BP-PA-20210507234900732-959110 and number of fellows 745683)
   for financial support.
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NR 129
TC 7
Z9 7
U1 1
U2 14
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD AUG
PY 2022
VL 23
IS 15
AR 8277
DI 10.3390/ijms23158277
PG 13
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 3R8YY
UT WOS:000839193100001
PM 35955411
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Bryniarski, P
   Nazimek, K
   Marcinkiewicz, J
AF Bryniarski, Pawel
   Nazimek, Katarzyna
   Marcinkiewicz, Janusz
TI Immunomodulatory Activity of the Most Commonly Used Antihypertensive
   Drugs-Angiotensin Converting Enzyme Inhibitors and Angiotensin II
   Receptor Blockers
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE angiotensin converting enzyme inhibitors; angiotensin II receptor
   blockers; immunomodulation; immunology; cellular response; humoral
   response
ID TUMOR-NECROSIS-FACTOR; NF-KAPPA-B; NATURAL-KILLER ACTIVITY; TNF-ALPHA;
   BLOOD-PRESSURE; TYPE-1 RECEPTOR; TGF-BETA; OXIDATIVE STRESS;
   IMMUNE-RESPONSE; ACE-INHIBITORS
AB This review article is focused on antihypertensive drugs, namely angiotensin converting enzyme inhibitors (ACEI) and angiotensin II receptor blockers (ARB), and their immunomodulatory properties reported in hypertensive patients as well as in experimental settings involving studies on animal models and cell lines. The immune regulatory action of ACEI and ARB is mainly connected with the inhibition of proinflammatory cytokine secretion, diminished expression of adhesion molecules, and normalization of CRP concentration in the blood plasma. The topic has significant importance in future medical practice in the therapy of patients with comorbidities with underlying chronic inflammatory responses. Thus, this additional effect of immune regulatory action of ACEI and ARB may also benefit the treatment of patients with metabolic syndrome, allergies, or autoimmune disorders.
C1 [Bryniarski, Pawel; Nazimek, Katarzyna; Marcinkiewicz, Janusz] Jagiellonian Univ, Dept Immunol, Med Coll, 18 Czysta St, PL-31121 Krakow, Poland.
C3 Jagiellonian University; Collegium Medicum Jagiellonian University
RP Bryniarski, P (corresponding author), Jagiellonian Univ, Dept Immunol, Med Coll, 18 Czysta St, PL-31121 Krakow, Poland.
EM pablo.bryniarski@uj.edu.pl; katarzyna.nazimek@uj.edu.pl;
   janusz.marcinkiewicz@uj.edu.pl
RI Bryniarski, Paweł/ABB-4067-2021; Nazimek, Katarzyna/X-8292-2018
OI Nazimek, Katarzyna/0000-0003-1302-117X
FU Polish Ministry of Science and Higher Education [0168/DIA/2017/46]
FX This study entitled "The influence of diuretics and combination drugs
   (diuretic + ACEI) on the immunological activity of mouse macrophages",
   was supported by The Polish Ministry of Science and Higher Education
   under the "Diamond Grant" program (0168/DIA/2017/46).
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NR 145
TC 36
Z9 37
U1 0
U2 16
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD FEB
PY 2022
VL 23
IS 3
AR 1772
DI 10.3390/ijms23031772
PG 19
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA ZF2JT
UT WOS:000759398800001
PM 35163696
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU McGlennon, TW
   Buchwald, JN
   Pories, WJ
   Yu, F
   Roberts, A
   Ahnfeldt, EP
   Menon, R
   Buchwald, H
AF McGlennon, T. W.
   Buchwald, J. N.
   Pories, Walter J.
   Yu, Fang
   Roberts, Arthur
   Ahnfeldt, Eric P.
   Menon, Rukmini
   Buchwald, Henry
TI Part 2: Bypassing TBI-Metabolic Surgery and the Link Between Obesity and
   Traumatic Brain Injury-A Review
SO OBESITY SURGERY
LA English
DT Review
DE Metabolic surgery; Bariatric surgery; Obesity; Traumatic brain injury;
   TBI
ID POSTTRAUMATIC-STRESS-DISORDER; OBSTRUCTIVE SLEEP-APNEA; INTENTIONAL
   WEIGHT-LOSS; IDIOPATHIC INTRACRANIAL HYPERTENSION; BODY-MASS INDEX;
   LOW-FAT DIET; BARIATRIC SURGERY; COGNITIVE FUNCTION; GASTRIC BYPASS;
   DEPRESSIVE SYMPTOMS
AB Obesity is a common outcome of traumatic brain injury (TBI) that exacerbates principal TBI symptom domains identified as common areas of post-TBI long-term dysfunction. Obesity is also associated with increased risk of later-life dementia and Alzheimer's disease. Patients with obesity and chronic TBI may be more vulnerable to long-term mental abnormalities. This review explores the question of whether weight loss induced by bariatric surgery could delay or perhaps even reverse the progression of mental deterioration. Bariatric surgery, with its induction of weight loss, remission of type 2 diabetes, and other expressions of the metabolic syndrome, improves metabolic efficiency, leads to reversal of brain lesions seen on imaging studies, and improves function. These observations suggest that metabolic/bariatric surgery may be the most effective therapy for TBI.
C1 [McGlennon, T. W.] McGlennon MotiMetr, Stat Div, Maiden Rock, WI USA.
   [Buchwald, J. N.] Medwrite, Div Sci Res Writing, Maiden Rock, WI USA.
   [Pories, Walter J.; Menon, Rukmini] East Carolina Univ, Brody Sch Med, Greenville, NC 27858 USA.
   [Yu, Fang] Arizona State Univ, Edson Coll Nursing & Hlth Innovat, Phoenix, AZ USA.
   [Roberts, Arthur] Living Heart Fdn, Little Silver, NJ USA.
   [Ahnfeldt, Eric P.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA.
   [Buchwald, Henry] Univ Minnesota, Sch Med, Minneapolis, MN 55455 USA.
C3 University of North Carolina; East Carolina University; Arizona State
   University; Arizona State University-Downtown Phoenix; Uniformed
   Services University of the Health Sciences - USA; University of
   Minnesota System; University of Minnesota Twin Cities
RP Buchwald, H (corresponding author), Univ Minnesota, Sch Med, Minneapolis, MN 55455 USA.
EM buchw001@umn.edu
OI Buchwald, Henry/0000-0002-5127-4488; Yu, Fang/0000-0002-9399-1987
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NR 117
TC 5
Z9 5
U1 0
U2 3
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0960-8923
EI 1708-0428
J9 OBES SURG
JI Obes. Surg.
PD JAN
PY 2021
VL 31
IS 1
BP 26
EP 35
DI 10.1007/s11695-020-05142-7
EA JAN 2021
PG 10
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Surgery
GA PT0OP
UT WOS:000605515200023
PM 33405185
DA 2025-06-11
ER

PT J
AU Schwasinger-Schmidt, TE
   Kachman, SD
   Harshman, LG
AF Schwasinger-Schmidt, T. E.
   Kachman, S. D.
   Harshman, L. G.
TI Evolution of starvation resistance in Drosophila melanogaster:
   measurement of direct and correlated responses to artificial selection
SO JOURNAL OF EVOLUTIONARY BIOLOGY
LA English
DT Article
DE body composition; Drosophila; laboratory selection; movement; starvation
ID STRESS RESISTANCE; DESICCATION RESISTANCE; METABOLIC SYNDROME;
   LONGEVITY; LINES; POPULATION
AB Laboratory selection for resistance to starvation has been conducted under relatively controlled conditions to investigate direct and correlated responses to artificial selection. With regard to starvation resistance, there are three physiological routes by which the trait can evolve: resource accumulation, energy conservation and starvation tolerance. A majority of energetic compounds and macromolecules including triglycerides, trehalose and other sugars, and soluble protein increased in abundance as a result of selection. Movement was additionally investigated with selected males moving less than control males and selected females exhibiting a similar response to selection. Results obtained from this study supported two of the possible evolutionary mechanisms for adaptation to starvation: energy compound storage and conservation. If the response to selection is based on an evolutionarily conserved pattern of genetic correlations (elevated lipid, elevated sugars and reduced movement), then the response to selection is medically relevant and the genetic architecture should be investigated in depth.
C1 [Harshman, L. G.] Univ Nebraska, Sch Biol Sci, Lincoln, NE 68588 USA.
   [Schwasinger-Schmidt, T. E.] Univ Kansas, Sch Med, Kansas City, KS USA.
   [Kachman, S. D.] Univ Nebraska, Dept Stat, Lincoln, NE 68588 USA.
C3 University of Nebraska System; University of Nebraska Lincoln;
   University of Kansas; University of Kansas Medical Center; University of
   Nebraska System; University of Nebraska Lincoln
RP Harshman, LG (corresponding author), Univ Nebraska, Sch Biol Sci, 348 Manter Hall, Lincoln, NE 68588 USA.
EM lharsh@unlserve.unl.edu
RI Schwasinger-Schmidt, Tiffany/L-2644-2019; Schwasinger-Schmidt,
   Tiffany/LCE-0707-2024
OI Schwasinger-Schmidt, Tiffany/0000-0002-6084-7866; Kachman,
   Stephen/0000-0003-0506-513X
FU NIH [RO1 DK074136]
FX Brian Becker and Courtney Peretto (University of Nebraska-Lincoln)
   provided capable laboratory assistance in the course of this study. Tim
   Carr provided useful discussion and insight into metabolism. Sergey
   Nuzhdin (University of Southern California) provided the inbred lines
   used to start the base population used for selection. This research was
   supported by a grant from the NIH (RO1 DK074136).
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NR 25
TC 42
Z9 57
U1 1
U2 42
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1010-061X
J9 J EVOLUTION BIOL
JI J. Evol. Biol.
PD FEB
PY 2012
VL 25
IS 2
BP 378
EP 387
DI 10.1111/j.1420-9101.2011.02428.x
PG 10
WC Ecology; Evolutionary Biology; Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Evolutionary Biology; Genetics &
   Heredity
GA 875PI
UT WOS:000299043300014
PM 22151916
OA Bronze, Green Accepted, Green Published
DA 2025-06-11
ER

PT J
AU Dubrac, S
   Stoitzner, P
   Pirkebner, D
   Elentner, A
   Schoonjans, K
   Auwerx, J
   Saeland, S
   Hengster, P
   Fritsch, P
   Romani, N
   Schmuth, M
AF Dubrac, Sandrine
   Stoitzner, Patrizia
   Pirkebner, Daniela
   Elentner, Andreas
   Schoonjans, Kristina
   Auwerx, Johan
   Saeland, Sem
   Hengster, Paul
   Fritsch, Peter
   Romani, Nikolaus
   Schmuth, Matthias
TI Peroxisome proliferator-activated receptor-α activation inhibits
   langerhans cell function
SO JOURNAL OF IMMUNOLOGY
LA English
DT Article
ID NF-KAPPA-B; DERMAL DENDRITIC CELLS; PPAR-ALPHA; TNF-ALPHA;
   IMMUNE-RESPONSES; LYMPH-NODES; METABOLIC SYNDROME; NUCLEAR RECEPTORS;
   MURINE SKIN; FATTY-ACIDS
AB Epidermal Langerhans cells (LC) play a pivotal role in initiating and maintaining primary immune responses in the skin. In the present study, we asked whether peroxisome proliferator-activated receptor-alpha (PPAR alpha) activation modulates LC function. Our results show that PPAR alpha is expressed in immature LC and is down-regulated in mature LC suggesting that an early decrease of PPARa expression in LC may allow them to mature after contact with an Ag. We further show that pharmacologic PPAR alpha activation inhibits LC maturation, migratory capacity, cytokine expression, and the ability to drive T cell proliferation. Moreover, PPARa activation inhibits NF-kappa B but not stress-activated protein kinase/JNK, p38MAPK, and ERK1/2. In conclusion, PPAR alpha activation by endogenous ligands may provide a molecular signal that allows LC to remain in an immature state within the epidermis for extended periods of time despite minor environmental stimuli.
C1 Innsbruck Med Univ, Dept Dermatol, A-6020 Innsbruck, Austria.
   Innsbruck Med Univ, Kompetenzzentrum Med Tirol Zentraler Informat Die, Dept Gen & Transplant Surg, A-6020 Innsbruck, Austria.
   Inst Genet & Biol Cellulaire & Mol, Illkirch Graffenstaden, France.
   DermImmune, Lyon, France.
C3 Medical University of Innsbruck; Medical University of Innsbruck;
   Institut National de la Sante et de la Recherche Medicale (Inserm)
RP Dubrac, S (corresponding author), Innsbruck Med Univ, Dept Dermatol, Anich Str 35, A-6020 Innsbruck, Austria.
EM sandrine.dubrac@i-med.ac.at
RI Auwerx, Johan/ABE-9307-2021
OI Auwerx, Johan/0000-0002-5065-5393; Schmuth,
   Matthias/0000-0002-4064-1334; Schoonjans, Kristina/0000-0003-1247-4265;
   stoitzner, patrizia/0000-0002-8488-6704; Dubrac,
   Sandrine/0000-0002-2936-8488; Romani, Nikolaus/0000-0003-1614-9128
FU Austrian Science Fund FWF [P 16990] Funding Source: Medline
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NR 56
TC 40
Z9 42
U1 0
U2 6
PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-1767
EI 1550-6606
J9 J IMMUNOL
JI J. Immunol.
PD APR 1
PY 2007
VL 178
IS 7
BP 4362
EP 4372
DI 10.4049/jimmunol.178.7.4362
PG 11
WC Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology
GA 150EB
UT WOS:000245197300043
PM 17371993
OA Bronze
DA 2025-06-11
ER

PT J
AU Castellano, JM
   Perona, JS
AF Castellano, J. M.
   Perona, J. S.
TI Effects of virgin olive oil phenolic compounds on health: solid evidence
   or just another fiasco?
SO GRASAS Y ACEITES
LA English
DT Article
DE Evidence; Health; Hydroxytyrosol; Oleocanthal; Phenolic Compounds;
   Virgin Olive Oil
ID OLEUROPEIN AGLYCONE; METABOLIC SYNDROME; RISK-FACTORS; ANTIOXIDANT;
   HYDROXYTYROSOL; POLYPHENOLS; RESVERATROL; DYSFUNCTION; CLEARANCE;
   TOXICITY
AB Current research suggests that virgin olive oil (VOO) phenolics are potent preventive and therapeutic agents against metabolic diseases associated with inflammation and oxidative stress. Evidence-based medicine requires these effects be proved in randomized controlled trials (RCT), which are then assessed in meta-analyses, to ensure that the alleged health benefits really proceed in humans. The available evidence is limited to the ability of VOO phenolic compounds to protect lipoproteins from oxidation and to reduce systolic pressure in hypertensive individuals. No RCT assessing the effects of VOO phenolics on diabetes and neurodegenerative diseases have been performed, and those focused on osteoarthritis and cancer provided very scarce information. Therefore, RCT in extensive and diverse population groups, with different disorders and phenolic doses adjusted to usual VOO consumptions are necessary to achieve high quality scientific evidence before nutritional recommendations can be given to the general public.
C1 [Castellano, J. M.; Perona, J. S.] CSIC, Inst Grasa, Campus Univ Pablo de Olavide,Bldg 46, Seville 41013, Spain.
C3 Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Instituto
   de la Grasa (IG)
RP Perona, JS (corresponding author), CSIC, Inst Grasa, Campus Univ Pablo de Olavide,Bldg 46, Seville 41013, Spain.
EM perona@ig.csic.es
RI Castellano Orozco, Jose Maria/L-6220-2014; Perona, Javier/B-9721-2014
OI Castellano Orozco, Jose Maria/0000-0003-3051-3264; Perona,
   Javier/0000-0001-5919-993X
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NR 52
TC 3
Z9 4
U1 0
U2 7
PU CONSEJO SUPERIOR INVESTIGACIONES CIENTIFICAS-CSIC
PI MADRID
PA VITRUVIO 8, 28006 MADRID, SPAIN
SN 0017-3495
EI 1988-4214
J9 GRASAS ACEITES
JI Grasas Aceites
PD APR-JUN
PY 2021
VL 72
IS 2
AR e404
DI 10.3989/gya.0217201
PG 11
WC Chemistry, Applied; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Food Science & Technology
GA SO3TW
UT WOS:000658900100004
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Han, MS
   Perry, RJ
   Camporez, JP
   Scherer, PE
   Shulman, GI
   Gao, GP
   Davis, RJ
AF Han, Myoung Sook
   Perry, Rachel J.
   Camporez, Joao-Paulo
   Scherer, Philipp E.
   Shulman, Gerald I.
   Gao, Guangping
   Davis, Roger J.
TI A feed-forward regulatory loop in adipose tissue promotes signaling by
   the hepatokine FGF21
SO GENES & DEVELOPMENT
LA English
DT Article
DE autocrine; endocrine; FGF21; JNK; organ cross-talk
ID GLUCOSE-HOMEOSTASIS; INSULIN SENSITIVITY; PPAR-ALPHA;
   METABOLIC-REGULATION; ENERGY-EXPENDITURE; NERVOUS-SYSTEM; AXIS;
   TRANSDUCTION; INFLAMMATION; EXPRESSION
AB The cJun NH2-terminal kinase (JNK) signaling pathway is activated by metabolic stress and promotes the development of metabolic syndrome, including hyperglycemia, hyperlipidemia, and insulin resistance. This integrated physiological response involves cross-talk between different organs. Here we demonstrate that JNK signaling in adipocytes causes an increased circulating concentration of the hepatokine fibroblast growth factor 21 (FGF21) that regulates systemic metabolism. The mechanism of organ crosstalk is mediated by a feed-forward regulatory loop caused by JNK-regulated FGF21 autocrine signaling in adipocytes that promotes increased expression of the adipokine adiponectin and subsequent hepatic expression of the hormone FGF21. The mechanism of organ cross-talk places circulating adiponectin downstream of autocrine FGF21 expressed by adipocytes and upstream of endocrine FGF21 expressed by hepatocytes. This regulatory loop represents a novel signaling paradigm that connects autocrine and endocrine signaling modes of the same hormone in different tissues.
C1 [Han, Myoung Sook; Davis, Roger J.] Univ Massachusetts, Sch Med, Program Mol Med, Worcester, MA 01605 USA.
   [Perry, Rachel J.; Camporez, Joao-Paulo; Shulman, Gerald I.] Yale Sch Med, Dept Internal Med, New Haven, CT 06520 USA.
   [Perry, Rachel J.; Shulman, Gerald I.] Yale Sch Med, Dept Cellular & Mol Physiol, New Haven, CT 06520 USA.
   [Scherer, Philipp E.] Univ Texas Southwestern Med Ctr Dallas, Touchstone Diabet Ctr, Dallas, TX 75390 USA.
   [Scherer, Philipp E.] Univ Texas Southwestern Med Ctr Dallas, Dept Internal Med, Dallas, TX 75390 USA.
   [Scherer, Philipp E.] Univ Texas Southwestern Med Ctr Dallas, Dept Cell Biol, Dallas, TX 75390 USA.
   [Gao, Guangping] Univ Massachusetts, Sch Med, Horae Gene Therapy Ctr, Worcester, MA 01605 USA.
   [Camporez, Joao-Paulo] Univ Sao Paulo, Dept Physiol, Ribeirao Preto Sch Med, BR-05508000 Sao Paulo, Brazil.
C3 University of Massachusetts System; University of Massachusetts
   Worcester; Yale University; Yale University; University of Texas System;
   University of Texas Southwestern Medical Center Dallas; University of
   Texas System; University of Texas Southwestern Medical Center Dallas;
   University of Texas System; University of Texas Southwestern Medical
   Center Dallas; University of Massachusetts System; University of
   Massachusetts Worcester; Universidade de Sao Paulo
RP Davis, RJ (corresponding author), Univ Massachusetts, Sch Med, Program Mol Med, Worcester, MA 01605 USA.
EM roger.davis@umassmed.edu
RI Shulman, Gerald/P-7176-2019; Scherer, Philipp/K-7819-2012; Camporez,
   Joao/B-9122-2015
OI Han, Myoung Sook/0000-0002-7226-2590; Perry, Rachel/0000-0003-0748-8064;
   Davis, Roger/0000-0002-0130-1652; Shulman, Gerald/0000-0003-1529-5668;
   Camporez, Joao Paulo/0000-0003-3486-4301
FU American Heart Association [19CDA34660270]; Sao Paulo Research
   Foundation [2018/04956-5]; National Institutes of Health [R01 DK107220,
   R01 DK112698, R00 CA215315, R01 DK55758, P01 AG051459, R01 DK116774, R01
   DK114793, P30 DK045735]; National Institute of Diabetes and Digestive
   and Kidney Diseases [R01DK114793, R01DK116774, R01DK121545] Funding
   Source: NIH RePORTER; Fundacao de Amparo a Pesquisa do Estado de Sao
   Paulo (FAPESP) [18/04956-5] Funding Source: FAPESP; American Heart
   Association (AHA) [19CDA34660270] Funding Source: American Heart
   Association (AHA)
FX We thank Aafreen Syed, Armanda Roy, Shanzah Chaudhry, Julie
   Cavanaugh-Kyros, Ali Nasiri, and Xiaoxian Ma for expert technical
   assistance, and Kathy Gemme for administrative assistance. These studies
   were supported by American Heart Association grant 19CDA34660270 to
   M.S.H., Sao Paulo Research Foundation grant 2018/04956-5 to J.-P.C., and
   National Institutes of Health grants R01 DK107220 and R01 DK112698 to
   R.J.D., R00 CA215315 to R.J.P., R01 DK55758 and P01 AG051459 to P.E.S.,
   and R01 DK116774, R01 DK114793, and P30 DK045735 to G.I.S.
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NR 60
TC 27
Z9 30
U1 0
U2 12
PU COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
PI COLD SPRING HARBOR
PA 1 BUNGTOWN RD, COLD SPRING HARBOR, NY 11724 USA
SN 0890-9369
EI 1549-5477
J9 GENE DEV
JI Genes Dev.
PD JAN 1
PY 2021
VL 35
IS 1-2
BP 133
EP 146
DI 10.1101/gad.344556.120
PG 14
WC Cell Biology; Developmental Biology; Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Developmental Biology; Genetics & Heredity
GA PR1ZX
UT WOS:000607042700004
PM 33334822
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Hajihasani, MM
   Soheili, V
   Zirak, MR
   Sahebkar, A
   Shakeri, A
AF Hajihasani, Mohammad Mahdi
   Soheili, Vahid
   Zirak, Mohammad Reza
   Sahebkar, Amirhossein
   Shakeri, Abolfazl
TI Natural products as safeguards against monosodium glutamate-induced
   toxicity
SO IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
LA English
DT Review
DE Food industry; Herbal medicine; Monosodium glutamate; Neurotoxicity;
   Phytochemical
ID INDUCED OXIDATIVE STRESS; GLOBAL BRAIN ISCHEMIA; VITAMIN-C; ANTIOXIDANT
   STATUS; ALPHA-TOCOPHEROL; GINKGO-BILOBA; INDUCED NEUROTOXICITY;
   LIPID-PEROXIDATION; METABOLIC SYNDROME; INDUCED LIVER
AB Monosodium glutamate is a sodium salt of a nonessential amino acid, L-glutamic acid, which is widely used in food industry. Glutamate plays an important role in principal brain functions including formation and stabilization of synapses, memory, cognition, learning, as well as cellular metabolism. However, ingestion of foodstuffs rich in monosodium glutamate can result in the outbreak of several health disorders such as neurotoxicity, hepatotoxicity, obesity and diabetes. The usage of medicinal plants and their natural products as a therapy against MSG used in food industry has been suggested to be protective. Calendula officinalis, Curcuma longa, Green Tea, Ginkgo biloba and vitamins are some of the main natural products with protective effect against mentioned monosodium glutamate toxicity through different mechanisms. This review provides a summary on the toxicity of monosodium glutamate and the protective effects of natural products against monosodium glutamate -induced toxicity.
C1 [Hajihasani, Mohammad Mahdi; Soheili, Vahid] Mashhad Univ Med Sci, Sch Pharm, Dept Pharmaceut Control, Mashhad, Razavi Khorasan, Iran.
   [Zirak, Mohammad Reza] Mashhad Univ Med Sci, Sch Pharm, Dept Pharmacodynam & Toxicol, Mashhad, Razavi Khorasan, Iran.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Neurogen Inflammat Res Ctr, Mashhad, Razavi Khorasan, Iran.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Biotechnol Res Ctr, Pharmaceut Technol Inst, Mashhad, Razavi Khorasan, Iran.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Sch Pharm, Mashhad, Razavi Khorasan, Iran.
   [Shakeri, Abolfazl] Mashhad Univ Med Sci, Sch Pharm, Dept Pharmacognosy, Mashhad, Razavi Khorasan, Iran.
C3 Mashhad University of Medical Sciences; Mashhad University of Medical
   Sciences; Mashhad University of Medical Sciences; Mashhad University of
   Medical Sciences; Mashhad University of Medical Sciences; Mashhad
   University of Medical Sciences
RP Shakeri, A (corresponding author), Mashhad Univ Med Sci, Sch Pharm, Dept Pharmacognosy, Mashhad, Razavi Khorasan, Iran.
EM plantchem87@gmail.com
RI Zirak, Mohammad/AAB-6266-2020; Soheili, Vahid/AAD-5063-2019; Sahebkar,
   Amirhossein/B-5124-2018
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NR 210
TC 40
Z9 43
U1 5
U2 40
PU MASHHAD UNIV MED SCIENCES
PI MASHHAD
PA VICE-CHANCELLOR FOR RES CTR OFF IJBMS, DANESHGAH ST, PO BOX 9138813944 -
   445, MASHHAD, 00000, IRAN
SN 2008-3866
EI 2008-3874
J9 IRAN J BASIC MED SCI
JI Iran. J. Basic Med. Sci.
PD APR
PY 2020
VL 23
IS 4
BP 416
EP 430
DI 10.22038/IJBMS.2020.43060.10123
PG 15
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA KQ3CS
UT WOS:000516805200002
PM 32489556
DA 2025-06-11
ER

PT J
AU Septar, A
   Ilie, I
   Tulin, A
   Terzea, D
   Hortopan, D
   Goldstein, A
   Chiriac, I
   Tupea, C
   Oprea, L
   Banica, A
   Manda, D
   Caragheorgheopol, A
   Iordachescu, C
   Ciubotaru, V
   Musat, M
AF Septar, Ailin
   Ilie, Iuliana
   Tulin, Adrian
   Terzea, Dana
   Hortopan, Dan
   Goldstein, Andrei
   Chiriac, Iulia
   Tupea, Claudiu
   Oprea, Luciana
   Banica, Andreea
   Manda, Dana
   Caragheorgheopol, Andra
   Iordachescu, Carmen
   Ciubotaru, Vasilie
   Musat, Madalina
TI A Rare Encounter - Papillary Thyroid Cancer Meets Cushing's Disease Case
   report and literature review
SO ROMANIAN BIOTECHNOLOGICAL LETTERS
LA English
DT Review
DE Glucocorticoids (GC); microcarcinoma (PTMC)
ID HIGH PREVALENCE; CARCINOMA; MUTATION; FEATURES
AB Glucocorticoids (GC) play major role in the physiologic stress response. However chronic exposure to glucocorticoids as seen in Cushing's disease (CD) has detrimental effects on multiple systems: cardiovascular, metabolic, immune, psychological. Papillary thyroid carcinoma is the most common type of thyroid cancer and the most common endocrine malignancy and its incidence has been increasing lately. However concomitant thyroid cancer with CD is uncommon.
   We report a case of papillary thyroid microcarcinoma (PTMC) in a woman with metabolic syndrome and multinodular goiter, diagnosed with CD due to a corticotroph pituitary microadenoma. Both CD and thyroid cancer were cured after surgery.
   A review of literature shown association between papillary thyroid carcinoma and Cushing's disease is very rare and so far there is no known genetic mutation to link the two neoplastic conditions. While this may be a random association, possible implications of chronic GC exposure in cancer progression are discussed.
C1 [Tulin, Adrian; Terzea, Dana; Musat, Madalina] Carol Davila Univ Med & Pharm, Bucharest, Romania.
   [Septar, Ailin; Ilie, Iuliana; Terzea, Dana; Hortopan, Dan; Goldstein, Andrei; Chiriac, Iulia; Tupea, Claudiu; Oprea, Luciana; Banica, Andreea; Manda, Dana; Caragheorgheopol, Andra; Iordachescu, Carmen; Musat, Madalina] CI Parhon Natl Inst Endocrinol, Bucharest, Romania.
   [Tulin, Adrian] Prof Dr Agrippa Ionescu Emergency Hosp Bucharest, Bucharest, Romania.
   [Ciubotaru, Vasilie] Emergency Clin Hosp Bagdasar Arseni, Bucharest, Romania.
C3 Carol Davila University of Medicine & Pharmacy; National Institute of
   Endocrinology C.I. Parhon
RP Musat, M (corresponding author), CI Parhon Natl Inst Endocrinol, Endem Goiter Dept, Bd Aviatorilor 34-38,Sect 1, Bucharest, Romania.
EM mdmusat@yahoo.com
RI Manda, Dana/AAZ-5704-2020; Musat, Madalina Iuliana/MSX-6882-2025; Oprea,
   Luciana/HPF-3758-2023
OI Ilie, Iuliana/0000-0001-6659-3417; Oprea, Luciana/0000-0002-1200-9518
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NR 26
TC 0
Z9 0
U1 0
U2 5
PU ARS DOCENDI
PI BUCHAREST
PA SOS PANDURI 90, SECT 5, BUCHAREST, RO-050663, ROMANIA
SN 1224-5984
J9 ROM BIOTECH LETT
JI Rom. Biotech. Lett.
PD JUL-AUG
PY 2019
VL 24
IS 4
BP 736
EP 741
DI 10.25083/rbl/24.4/736.741
PG 6
WC Biotechnology & Applied Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology
GA IS4IZ
UT WOS:000482118200021
OA gold
DA 2025-06-11
ER

PT J
AU Takagi, M
   Uno, H
   Nishi, R
   Sugimoto, M
   Hasegawa, S
   Piao, J
   Ihara, N
   Kanai, S
   Kakei, S
   Tamura, Y
   Suganami, T
   Kamei, Y
   Shimizu, T
   Yasuda, A
   Ogawa, Y
   Mizutani, S
AF Takagi, Masatoshi
   Uno, Hatsume
   Nishi, Rina
   Sugimoto, Masataka
   Hasegawa, Setsuko
   Piao, Jinhua
   Ihara, Norimasa
   Kanai, Sayaka
   Kakei, Saori
   Tamura, Yoshifumi
   Suganami, Takayoshi
   Kamei, Yasutomi
   Shimizu, Toshiaki
   Yasuda, Akio
   Ogawa, Yoshihiro
   Mizutani, Shuki
TI ATM Regulates Adipocyte Differentiation and Contributes to Glucose
   Homeostasis
SO CELL REPORTS
LA English
DT Article
ID DNA-DAMAGE; C/EBP-BETA; ATAXIA-TELANGIECTASIA; INSULIN-RESISTANCE;
   DIABETES-MELLITUS; METABOLIC SYNDROME; OXIDATIVE STRESS; MOUSE MODEL;
   PPAR-GAMMA; PHOSPHORYLATION
AB Ataxia-telangiectasia (A-T) patients occasionally develop diabetes mellitus. However, only limited attempts have been made to gain insight into the molecular mechanism of diabetes mellitus development in A-T patients. We found that Atm(-/-) mice were insulin resistant and possessed less subcutaneous adipose tissue as well as a lower level of serum adiponectin than Atm(+/+) mice. Furthermore, in vitro studies revealed impaired adipocyte differentiation in Atm(-/-) cells caused by the lack of induction of C/EBP alpha and PPAR gamma, crucial transcription factors involved in adipocyte differentiation. Interestingly, ATM was activated by stimuli that induced differentiation, and the binding of ATM to C/EBP beta and p300 was involved in the transcriptional regulation of C/EBP alpha and adipocyte differentiation. Thus, our study sheds light on the poorly understood role of ATM in the pathogenesis of glucose intolerance in A-T patients and provides insight into the role of ATM in glucose metabolism.
C1 [Takagi, Masatoshi; Uno, Hatsume; Nishi, Rina; Hasegawa, Setsuko; Piao, Jinhua; Mizutani, Shuki] Tokyo Med & Dent Univ, Grad Sch Med, Dept Pediat & Dev Biol, Bunkyo Ku, Tokyo 1138519, Japan.
   [Uno, Hatsume] Sony Corp, Med Business Unit, Bunkyo Ku, Tokyo 1138519, Japan.
   [Sugimoto, Masataka; Yasuda, Akio] NCGG, Natl Inst Longev Sci, Sect Biochem, Obu, Aichi, Japan.
   [Ihara, Norimasa] Natl Res Inst Child Hlth & Dev, Dept Reprod Biol, Setagaya Ku, Tokyo 1570074, Japan.
   [Kanai, Sayaka; Ogawa, Yoshihiro] Tokyo Med & Dent Univ, Japan Sci & Technol Agcy, Grad Sch Med, Dept Mol Endocrinol & Metab,CREST,Bunkyo Ku, Tokyo 1138519, Japan.
   [Kakei, Saori; Tamura, Yoshifumi] Juntendo Univ, Sch Med, Dept Med Metab & Endocrinol, Bunkyo Ku, Tokyo 1130033, Japan.
   [Suganami, Takayoshi] Tokyo Med & Dent Univ, Japan Sci & Technol Agcy, Grad Sch Med & Dent Sci, Dept Organ Network & Metab,PRESTO,Bunkyo Ku, Tokyo 1138519, Japan.
   [Kamei, Yasutomi] Kyoto Prefectural Univ, Grad Sch Environm & Life Sci, Lab Mol Nutr, Kyoto 6068522, Japan.
   [Shimizu, Toshiaki] Juntendo Univ, Sch Med, Dept Pediat & Adolescent Med, Bunkyo Ku, Tokyo 1130033, Japan.
C3 Institute of Science Tokyo; Tokyo Medical & Dental University (TMDU);
   Sony Corporation; National Center for Child Health & Development -
   Japan; Institute of Science Tokyo; Tokyo Medical & Dental University
   (TMDU); Japan Science & Technology Agency (JST); Juntendo University;
   Japan Science & Technology Agency (JST); Institute of Science Tokyo;
   Tokyo Medical & Dental University (TMDU); Kyoto Prefectural University;
   Juntendo University
RP Takagi, M (corresponding author), Tokyo Med & Dent Univ, Grad Sch Med, Dept Pediat & Dev Biol, Bunkyo Ku, 1-5-45 Yushima, Tokyo 1138519, Japan.
EM m.takagi.ped@tmd.ac.jp
RI SUGANAMI, Takayoshi/A-9475-2016; Tamura, Yoshifumi/AFK-2430-2022;
   Nishii, Rina/AAC-4177-2022; Takagi, Masatoshi/F-3713-2011
OI Ogawa, Yoshihiro/0000-0002-0834-2836; Sugimoto,
   Masataka/0000-0001-8737-8097; Tamura, Yoshifumi/0000-0002-1685-7821;
   Suganami, Takayoshi/0000-0002-1918-0465
FU Ministry of Education, Science, and Culture [11939625]; Ministry of
   Health, Labor, and Welfare [26310401]; Uehara Foundation; Sumitomo
   Foundation; Morinaga Hoshikai; Takeda Science Foundation; Suzuken
   Memorial Foundation; Boshi Hoken Kyokai Foundation
FX This study was supported by a Grant-in-Aid from the Ministry of
   Education, Science, and Culture (grant 11939625), the Ministry of
   Health, Labor, and Welfare (grant 26310401), the Uehara Foundation, the
   Sumitomo Foundation, Morinaga Hoshikai, the Takeda Science Foundation,
   the Suzuken Memorial Foundation, and the Boshi Hoken Kyokai Foundation.
   We thank Atsuko Nishikawa for technical assistance. The Atm knockout
   mouse was kindly provided by Dr. Peter McKinnon (St. Jude Children's
   Research Hospital, Memphis, TN). The Atm<SUP>+/+</SUP> and
   Atm<SUP>-/-</SUP> MEF cell lines were kindly provided by Dr. Charles
   Sherr (St. Jude Children's Research Hospital). We thank Hikari Taka and
   Tsutomu Fujimura (Juntendo University, Tokyo) for performing the LC-MS
   analysis. We thank Kevin Urayama (Tokyo Medical and Dental University)
   for critical reading of the manuscript.
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NR 59
TC 24
Z9 28
U1 0
U2 15
PU CELL PRESS
PI CAMBRIDGE
PA 50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA
SN 2211-1247
J9 CELL REP
JI Cell Reports
PD FEB 17
PY 2015
VL 10
IS 6
BP 957
EP 967
DI 10.1016/j.celrep.2015.01.027
PG 11
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA CB2ET
UT WOS:000349440200012
PM 25683718
OA gold
DA 2025-06-11
ER

PT J
AU Girigoswami, K
   Arunkumar, R
   Girigoswami, A
AF Girigoswami, Koyeli
   Arunkumar, Radhakrishnan
   Girigoswami, Agnishwar
TI Management of hypertension addressing hyperuricaemia: introduction of
   nano-based approaches
SO ANNALS OF MEDICINE
LA English
DT Review
DE Xanthine oxidase; febuxostat; allopurinol; blood pressure; uric acid
ID SERUM URIC-ACID; XANTHINE-OXIDASE; CARDIOVASCULAR-DISEASE; METABOLIC
   SYNDROME; OXIDATIVE STRESS; FEBUXOSTAT; OXIDOREDUCTASE; ALLOPURINOL;
   INHIBITOR; GOUT
AB Uric acid (UA) levels in blood serum have been associated with hypertension, indicating a potential causal relationship between high serum UA levels and the progression of hypertension. Therefore, the reduction of serum UA level is considered a potential strategy for lowering and mitigating blood pressure. If an individual is at risk of developing or already manifesting elevated blood pressure, this intervention could be an integral part of a comprehensive treatment plan. By addressing hyperuricaemia, practitioners may subsidize the optimization of blood pressure regulation, which illustrates the importance of addressing UA levels as a valuable strategy within the broader context of hypertension management. In this analysis, we outlined the operational principles of effective xanthine oxidase inhibitors for the treatment of hyperuricaemia and hypertension, along with an exploration of the contribution of nanotechnology to this field.
C1 [Girigoswami, Koyeli; Girigoswami, Agnishwar] Chettinad Acad Res & Educ CARE, Chettinad Hosp & Res Inst CHRI, Fac Allied Hlth Sci, Med Bionanotechnol, Chennai 603103, Tamil Nadu, India.
   [Arunkumar, Radhakrishnan] Chettinad Acad Res & Educ CARE, Chettinad Hosp & Res Inst CHRI, Dept Pharmacol, Chennai, India.
RP Girigoswami, A (corresponding author), Chettinad Acad Res & Educ CARE, Chettinad Hosp & Res Inst CHRI, Fac Allied Hlth Sci, Med Bionanotechnol, Chennai 603103, Tamil Nadu, India.
EM agnishwarg@gmail.com
RI Girigoswami, Koyeli/X-9431-2018; Girigoswami, Agnishwar/A-6355-2009
OI Girigoswami, Koyeli/0000-0003-1554-5241; Girigoswami,
   Agnishwar/0000-0003-0475-2544
FU CARE
FX CARE acknowledges the infrastructural and financial support.
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NR 148
TC 1
Z9 1
U1 2
U2 12
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0785-3890
EI 1365-2060
J9 ANN MED
JI Ann. Med.
PD DEC 31
PY 2024
VL 56
IS 1
AR 2352022
DI 10.1080/07853890.2024.2352022
PG 19
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA RI2E4
UT WOS:001226961700001
PM 38753584
OA gold
DA 2025-06-11
ER

PT J
AU Öksüz, M
   Göbel, P
AF Oksuz, Merve
   Gobel, Pinar
TI Obesity, Hypertension, and Kidney Dysfunction: Mechanical Links
SO CURRENT NUTRITION & FOOD SCIENCE
LA English
DT Review
DE Abnormal kidney dysfunction; cardiovascular risk; chronic kidney
   disease; pathophysiological mechanisms; glomerular filtration rate;
   hypertension risk
ID BLOOD-PRESSURE CONTROL; INSULIN-RESISTANCE; VASCULAR CALCIFICATION;
   METABOLIC SYNDROME; OXIDATIVE STRESS; EPICARDIAL FAT; DISEASE; WEIGHT;
   IMPACT; INFLAMMATION
AB Obesity is a risk factor for many diseases, including cardiovascular disease (CVD), gastrointestinal disorders, type 2 diabetes (T2DM), joint and muscle disorders, respiratory problems, and psychological problems that can significantly affect daily life. Hypertension affects more than a quarter of the adult population in developed countries, constituting an important health problem. In addition, its pathogenesis is not yet fully understood. Although hypertension is mostly seen in overweight and obese people, it is usually more difficult to control in obese people. It is well known that obesity is associated with the activation of both the sympathetic nervous system and the renin-angiotensin system, contributing to hypertension. Kidney dysfunction caused by obesity is a potential risk factor for cardiometabolic diseases, but the underlying mechanism remains unclear. The purpose of this review study is to investigate the mechanical links between obesity, hypertension, and kidney dysfunction.
C1 [Oksuz, Merve; Gobel, Pinar] Ankara Medipol Univ, Sch Hlth Sci, Dept Nutr & Dietet, TR-06080 Ankara, Turkiye.
C3 Ankara Medipol University
RP Öksüz, M (corresponding author), Ankara Medipol Univ, Sch Hlth Sci, Dept Nutr & Dietet, TR-06080 Ankara, Turkiye.
EM merve.oksuz2327@gmail.com
RI ; Gobel, Pinar/ADT-5693-2022
OI OKSUZ DAG, Merve/0000-0002-1602-4221; Gobel, Pinar/0000-0001-7152-1581
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NR 86
TC 0
Z9 0
U1 0
U2 6
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1573-4013
EI 2212-3881
J9 CURR NUTR FOOD SCI
JI Curr. Nutr. Food Sci.
PY 2023
VL 19
IS 3
BP 282
EP 290
DI 10.2174/1573401318666220622161438
PG 9
WC Nutrition & Dietetics
WE Emerging Sources Citation Index (ESCI)
SC Nutrition & Dietetics
GA F1RW9
UT WOS:000980199200008
DA 2025-06-11
ER

PT J
AU Nooreen, M
   Fatima, S
   Sultana, M
   Fatima, Z
   Unnissa, Z
AF Nooreen, Madiha
   Fatima, Shafia
   Sultana, Mahenaaz
   Fatima, Zeba
   Unnissa, Zeenath
TI GENETIC BACKGROUND ASSOCIATED WITH THE PROGRESSION OF NON- ALCOHOLIC
   FATTY LIVER DISEASE TO LIVER FIBROSIS
SO INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH
LA English
DT Review
DE Obesity; Insulin Resistance; Steatohepatitis; Oxidative Stress
ID CHRONIC HEPATITIS-C; GENOME-WIDE ASSOCIATION; APOLIPOPROTEIN-E;
   INSULIN-RESISTANCE; PROMOTER REGION; HISTOLOGIC FEATURES; JAPANESE
   PATIENTS; POLYMORPHISMS; SUSCEPTIBILITY; PNPLA3
AB Non-alcoholic fatty liver disease (NAFLD) is the most prevalent cause of chronic liver disease around the world. Individuals with obesity, diabetes, hyperlipidemia, metabolic syndrome, and insulin resistance are more likely to develop steatosis; however, it seldom progresses to steatohepatitis, fibrosis, and cirrhosis. In addition to the environmental factors, genetic variations further modify NAFLD progression. Several epidemiological, familial, and twin studies have elucidated the role of heritability. More recent genome-wide association studies and candidate gene studies have reported certain genes that play a key role in the susceptibility and advancement of NAFLD. The genetic basis of the disease further enhances the understanding of the pathogenic mechanism, which helps in developing novel biomarkers and therapeutic strategies. This review provides a summary of the genes involved in the susceptibility of NAFLD.
C1 [Nooreen, Madiha; Sultana, Mahenaaz] Mesco Coll Pharm, Dept Pharm Practice, Hyderabad 500006, Telangana, India.
   [Fatima, Shafia; Fatima, Zeba; Unnissa, Zeenath] Deccan Sch Pharm, Dept Pharm Practice, Hyderabad 500001, Telangana, India.
RP Nooreen, M (corresponding author), Mesco Coll Pharm, Dept Pharm Practice, Hyderabad 500006, Telangana, India.
EM madihanooreen94@gmail.com
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NR 76
TC 0
Z9 0
U1 0
U2 2
PU INT JOURNAL PHARMACEUTICAL SCIENCES & RESEARCH
PI HARYANA
PA 1117, SECTOR 12 A, PANCHKULA, HARYANA, 00000, INDIA
SN 0975-8232
J9 INT J PHARM SCI RES
JI Int. J. Pharm.l Sci. Res.
PD JAN
PY 2021
VL 12
IS 1
BP 85
EP 94
DI 10.13040/IJPSR.0975-8232.12(1).85-94
PG 10
WC Pharmacology & Pharmacy
WE Emerging Sources Citation Index (ESCI)
SC Pharmacology & Pharmacy
GA PO4FH
UT WOS:000605123200008
OA gold
DA 2025-06-11
ER

PT J
AU McGlennon, TW
   Buchwald, JN
   Pories, WJ
   Yu, F
   Roberts, A
   Ahnfeldt, EP
   Menon, R
   Buchwald, H
AF McGlennon, T. W.
   Buchwald, J. N.
   Pories, Walter J.
   Yu, Fang
   Roberts, Arthur
   Ahnfeldt, Eric P.
   Menon, Rukmini
   Buchwald, Henry
TI Bypassing TBI: Metabolic Surgery and the Link between Obesity and
   Traumatic Brain Injury-a Review
SO OBESITY SURGERY
LA English
DT Review
DE Metabolic surgery; Bariatric surgery; Obesity; Traumatic brain injury;
   TBI
ID POSTTRAUMATIC-STRESS-DISORDER; BODY-MASS INDEX; TYPE-2
   DIABETES-MELLITUS; OBSTRUCTIVE SLEEP-APNEA; LONG-TERM CONSEQUENCES;
   COGNITIVE FUNCTION; RISK-FACTORS; WEIGHT-GAIN; HEAD-INJURY; EXECUTIVE
   FUNCTIONS
AB Obesity is a common outcome of traumatic brain injury (TBI) that exacerbates principal TBI symptom domains identified as common areas of post-TBI long-term dysfunction. Obesity is also associated with increased risk of later-life dementia and Alzheimer's disease. Patients with obesity and chronic TBI may be more vulnerable to long-term mental abnormalities. This review explores the question of whether weight loss induced by bariatric surgery could delay or perhaps even reverse the progression of mental deterioration. Bariatric surgery, with its induction of weight loss, remission of type 2 diabetes, and other expressions of the metabolic syndrome, improves metabolic efficiency, leads to reversal of brain lesions seen on imaging studies, and improves function. These observations suggest that metabolic/bariatric surgery may be a most effective therapy for TBI.
C1 [McGlennon, T. W.] McGlennon MotiMetr, Stat Div, Maiden Rock, WI USA.
   [Buchwald, J. N.] Medwrite, Div Sci Res Writing, Maiden Rock, WI USA.
   [Pories, Walter J.; Menon, Rukmini] East Carolina Univ, Brody Sch Med, Greenville, NC 27858 USA.
   [Yu, Fang] Arizona State Univ, Edson Coll Nursing & Hlth Innovat, Phoenix, AZ USA.
   [Roberts, Arthur] Living Heart Fdn, Little Silver, NJ USA.
   [Ahnfeldt, Eric P.] Uniformed Serv Univ Hlth Sci, Bethesda, MA USA.
   [Buchwald, Henry] Univ Minnesota, Med Sch, Surg & Biomed Engn, Owen H & Sarah Davidson Wangensteen Chair Expt Su, 420 Delaware St SE,MMC 195, Minneapolis, MN 55455 USA.
C3 University of North Carolina; East Carolina University; Arizona State
   University; Arizona State University-Downtown Phoenix; Uniformed
   Services University of the Health Sciences - USA; University of
   Minnesota System; University of Minnesota Twin Cities
RP Buchwald, H (corresponding author), Univ Minnesota, Med Sch, Surg & Biomed Engn, Owen H & Sarah Davidson Wangensteen Chair Expt Su, 420 Delaware St SE,MMC 195, Minneapolis, MN 55455 USA.
EM buchw001@umn.edu
OI Buchwald, Henry/0000-0002-5127-4488; Yu, Fang/0000-0002-9399-1987
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NR 221
TC 15
Z9 15
U1 1
U2 7
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0960-8923
EI 1708-0428
J9 OBES SURG
JI Obes. Surg.
PD DEC
PY 2020
VL 30
IS 12
BP 4704
EP 4714
DI 10.1007/s11695-020-05065-3
EA OCT 2020
PG 11
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Surgery
GA PB1ER
UT WOS:000582992300001
PM 33125676
DA 2025-06-11
ER

PT J
AU Devarajan, A
AF Devarajan, Asokan
TI Cross-talk between renal lithogenesis and atherosclerosis: an unveiled
   link between kidney stone formation and cardiovascular diseases
SO CLINICAL SCIENCE
LA English
DT Review
ID CALCIUM-OXALATE CRYSTALS; URIC-ACID; METABOLIC SYNDROME; OXIDATIVE
   STRESS; ENDOTHELIAL DYSFUNCTION; BINDING-PROTEIN; RISK; NEPHROLITHIASIS;
   ASSOCIATION; CELLS
AB The prevalence of kidney stones and cardiovascular diseases (CVDs) are increasing throughout the world. Both diseases are chronic and characterized by accumulation of oxidized proteins and lipids in the renal tissue and arterial wall, respectively. Emerging studies have revealed a positive association between nephrolithiasis and CVDs. Based on preclinical and clinical evidences, this review discusses: (i) stone forming risk factors, crystal nucleation, aggregation, injury-induced crystal retention, and stone formation, (ii) CVD risk factors such as dyslipidemia, perturbation of gut microbiome, obesity, free radical-induced lipoprotein oxidation, and retention in the arterial wall, subsequent foam cell formation, and atherosclerosis, (iii) mechanism by which stone forming risk factors such as oxalate, calcium, uric acid, and infection contribute toward CVDs, and (iv) how CVD risk factors, such as cholesterol, phospholipids, and uric acid, contribute to kidney stone formation are described.
C1 [Devarajan, Asokan] Univ Calif Los Angeles, Dept Obstet & Gynecol, David Geffen Sch Med, Los Angeles, CA 90095 USA.
   [Devarajan, Asokan] Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Div Cardiol, 650 Charles E Young Dr South,CHS B8-127, Los Angeles, CA 90095 USA.
C3 University of California System; University of California Los Angeles;
   University of California Los Angeles Medical Center; David Geffen School
   of Medicine at UCLA; University of California System; University of
   California Los Angeles; University of California Los Angeles Medical
   Center; David Geffen School of Medicine at UCLA
RP Devarajan, A (corresponding author), Univ Calif Los Angeles, Dept Obstet & Gynecol, David Geffen Sch Med, Los Angeles, CA 90095 USA.; Devarajan, A (corresponding author), Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Div Cardiol, 650 Charles E Young Dr South,CHS B8-127, Los Angeles, CA 90095 USA.
EM adevarajan@mednet.ucla.edu
FU Department of Obstetrics and Gynecology, University of California at Los
   Angeles
FX This work was supported by the Department of Obstetrics and Gynecology,
   University of California at Los Angeles.
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NR 88
TC 32
Z9 34
U1 0
U2 10
PU PORTLAND PRESS LTD
PI LONDON
PA 1ST FLR, 10 QUEEN STREET PLACE, LONDON, ENGLAND
SN 0143-5221
EI 1470-8736
J9 CLIN SCI
JI Clin. Sci.
PD MAR 30
PY 2018
VL 132
IS 6
BP 615
EP 626
DI 10.1042/CS20171574
PG 12
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA GA3JG
UT WOS:000428224300001
PM 29559506
OA Bronze
DA 2025-06-11
ER

PT J
AU Avagimyan, A
   Pogosova, N
   Fogacci, F
   Aghajanova, E
   Djndoyan, Z
   Patoulias, D
   Lo Sasso, L
   Bernardi, M
   Faggiano, A
   Mohammadifard, N
   Neglia, D
   Carugo, S
   Cicero, A
   Rizzo, M
   Biondi-Zoccai, G
   De Caterina, R
   Sarrafzadegan, N
AF Avagimyan, Ashot
   Pogosova, Nana
   Fogacci, Federica
   Aghajanova, Elena
   Djndoyan, Zinaida
   Patoulias, Dimitrios
   Lo Sasso, Lorenzo
   Bernardi, Marco
   Faggiano, Andrea
   Mohammadifard, Noushin
   Neglia, Danilo
   Carugo, Stefano
   Cicero, Arrigo
   Rizzo, Manfredi
   Biondi-Zoccai, Giuseppe
   De Caterina, Raffaele
   Sarrafzadegan, Nizal
TI Triglyceride-glucose index (TyG) as a novel biomarker in the era of
   cardiometabolic medicine
SO INTERNATIONAL JOURNAL OF CARDIOLOGY
LA English
DT Article
DE Cardiodiabetology; Cardiovascular risk; Glucose; Triglycerides;
   Triglyceride-glucose index; TyG
ID ATHEROSCLEROTIC CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; OXIDATIVE
   STRESS; HEART-FAILURE; RISK; PATHOPHYSIOLOGY; PREVALENCE; OVERWEIGHT;
   IMMUNITY; OBESITY
AB In the period of increasing prevalence of metabolic disorders such as obesity and diabetes, healthcare professionals are facing significant challenges. Therefore, an accurate global assessment of insulin resistance is of utmost importance. Current medical research is focused on identifying an easily accessible and reproducible gold-standard surrogate marker for insulin resistance. Ideally, such a marker would enable healthcare providers to predict the risk of type 2 diabetes and cardiovascular diseases. The triglyceride-glucose index (TyG) is a promising marker for preventive cardiology and cardiometabolic medicine. This narrative review article aims to provide a comprehensive evaluation of the credibility of TyG as a surrogate marker of insulin resistance among patients at different stages across the cardiometabolic continuum. This assessment fully complies with evidence-based medicine and offers valuable insight into the clinical utility of TyG.
C1 [Avagimyan, Ashot] Isfahan Univ Med Sci, Isfahan Cardiovasc Res Inst, Esfahan, Iran.
   [Pogosova, Nana] Moscow MV Lomonosov State Univ, Assessment Ctr LASPI, Moscow, Russia.
   [Pogosova, Nana] PeoplesFriendship Univ Russia, RUDN Univ, Inst Med, Moscow, Russia.
   [Fogacci, Federica] Univ Bologna, Atherosclerosis & Metab Disorders Res Unit, Bologna, Italy.
   [Aghajanova, Elena] Yerevan State Med Univ, Endocrinol Dept, Mikaelyan Univ Clin, Yerevan, Armenia.
   [Aghajanova, Elena] Yerevan State Med Univ, Muratsan Univ Clin, Endocrinol Unit, Yerevan, Armenia.
   [Djndoyan, Zinaida] Yerevan State Med Univ, Mikaelyan Univ Clin, Internal Dis Propaedeut Dept, Yerevan, Armenia.
   [Djndoyan, Zinaida] Yerevan State Med Univ, Mikaelyan Univ Clin, Internal Dis Unit, Yerevan, Armenia.
   [Patoulias, Dimitrios] Aristotle Univ Thessaloniki, Gen Hosp Hippokrat, Outpatient Dept Cardiometab Med, Dept Cardiol 2, Thessaloniki, Greece.
   [Lo Sasso, Lorenzo] Univ Cattolica Sacro Cuore, Rome, Italy.
   [Bernardi, Marco; Biondi-Zoccai, Giuseppe] Sapienza Univ Rome, Dept Med & Surg Sci & Biotechnol, Latina, Italy.
   [Faggiano, Andrea; Carugo, Stefano] Fdn IRCCS Ca Granda Osped Maggiore Policlin, Dept Cardiothorac Vasc Dis, Milan, Italy.
   [Faggiano, Andrea; Carugo, Stefano] Univ Milan, Dept Clin Sci & Community Hlth, Milan, Italy.
   [Mohammadifard, Noushin] Isfahan Univ Med Sci, Cardiovasc Res Inst, WHO Collaborat Ctr, Nutr Dept, Esfahan, Iran.
   [Neglia, Danilo] Fdn CNR Reg Toscana Gabriele Monasterio, Cardiovasc Dept, CNR Res Area, Pisa, Italy.
   [Cicero, Arrigo] Alma Mater Studiorum Univ Bologna, Med & Surg Sci Dept, Hypertens & Cardiovasc Risk Res Unit, Bologna, Italy.
   [Cicero, Arrigo] IRCCS Policlin S Orsola Malpighi Bologna, Cardiovasc Med Unit, Bologna, Italy.
   [Rizzo, Manfredi] Univ Palermo, Sch Med, Dept Hlth Promot Mother & Child Care, Internal Med & Med Specialties Promise, I-90100 Palermo, Italy.
   [Rizzo, Manfredi] Mohammed Bin Rashid Univ Med & Hlth Sci MBRU, Dubai, U Arab Emirates.
   [Biondi-Zoccai, Giuseppe] GVM Care & Res, Maria Cecilia Hosp, Cotignola, Italy.
   [De Caterina, Raffaele] Univ Pisa, Dept Neuroradiol, I-56126 Pisa, Italy.
   [Sarrafzadegan, Nizal] Isfahan Univ Med Sci, Dept Biostat, Esfahan, Iran.
   [Sarrafzadegan, Nizal] Univ British Columbia, Fac Med, Sch Populat & Publ Hlth, Vancouver, BC, Canada.
C3 Isfahan University of Medical Sciences; Lomonosov Moscow State
   University; Peoples Friendship University of Russia; University of
   Bologna; Yerevan State Medical University; Yerevan State Medical
   University; Yerevan State Medical University; Yerevan State Medical
   University; Aristotle University of Thessaloniki; Catholic University of
   the Sacred Heart; IRCCS Policlinico Gemelli; Sapienza University Rome;
   IRCCS Ca Granda Ospedale Maggiore Policlinico; University of Milan;
   Isfahan University of Medical Sciences; University of Bologna;
   University of Palermo; Maria Cecilia Hospital; University of Pisa;
   Isfahan University of Medical Sciences; University of British Columbia
RP Avagimyan, A (corresponding author), Isfahan Univ Med Sci, Isfahan Cardiovasc Res Inst, Esfahan, Iran.
EM dr.ashotavagimyan@gmail.com
RI Patoulias, Dimitrios/AAD-3819-2019; RIZZO, MANFREDI/GZL-0551-2022;
   Carugo, Stefano/Z-2205-2019; Fogacci, Federica/R-5931-2016; Faggiano,
   Andrea/ABB-1007-2021; De Caterina, Raffaele/HTN-9576-2023;
   Mohammadifard, Noushin/M-2244-2018; Marco, Bernardi/ABZ-8626-2022;
   Biondi-Zoccai, Giuseppe/C-9670-2012; Cicero, Arrigo/H-8244-2019; Neglia,
   Danilo/AAR-6384-2020; Avagimyan, Ashot/ABU-8275-2022
OI CARUGO, STEFANO/0000-0002-5166-0899; Cicero, Arrigo Francesco
   Giuseppe/0000-0002-4367-3884
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Z9 18
U1 7
U2 13
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0167-5273
EI 1874-1754
J9 INT J CARDIOL
JI Int. J. Cardiol.
PD JAN 1
PY 2025
VL 418
AR 132663
DI 10.1016/j.ijcard.2024.132663
EA OCT 2024
PG 11
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA K8G5K
UT WOS:001346223500001
PM 39426418
DA 2025-06-11
ER

PT J
AU Zhang, H
   Hu, C
   Xue, JJ
   Jin, D
   Tian, LL
   Zhao, DQ
   Li, XY
   Qi, WX
AF Zhang, He
   Hu, Cheng
   Xue, Jiaojiao
   Jin, Di
   Tian, Lulu
   Zhao, Daqing
   Li, Xiangyan
   Qi, Wenxiu
TI Ginseng in vascular dysfunction: A review of therapeutic potentials and
   molecular mechanisms
SO PHYTOTHERAPY RESEARCH
LA English
DT Review
DE ginseng; vascular dysfunction; vascular endothelial cells; vascular
   smooth muscle cells
ID SMOOTH-MUSCLE-CELLS; KOREAN RED GINSENG; ENDOTHELIUM-DEPENDENT
   RELAXATION; ACTIVATED PROTEIN-KINASE; PANAX-GINSENG; OXIDATIVE STRESS;
   ANGIOTENSIN-II; BLOOD-VESSEL; INHIBITING ANGIOGENESIS; PROMOTES
   ANGIOGENESIS
AB Vascular dysfunction can lead to a variety of fatal diseases, including cardiovascular and cerebrovascular diseases, metabolic syndrome, and cancer. Although a large number of studies have reported the therapeutic effects of natural compounds on vascular-related diseases, ginseng is still the focus of research. Ginseng and its active substances have bioactive effects against different diseases with vascular dysfunction. In this review, we summarized the key molecular mechanisms and signaling pathways of ginseng, its different active ingredients or formula in the prevention and treatment of vascular-related diseases, including cardiac-cerebral vascular diseases, hypertension, diabetes complications, and cancer. Moreover, the bidirectional roles of ginseng in promoting or inhibiting angiogenesis have been highlighted. We systematically teased out the relationship between ginseng and vascular dysfunction, which could provide a basis for the clinical application of ginseng in the future.
C1 [Zhang, He; Zhao, Daqing; Li, Xiangyan; Qi, Wenxiu] Changchun Univ Chinese Med, Jilin Prov Key Lab Biomacromol Chinese Med, Key Lab Act Subst & Biol Mech Ginseng Efficacy, Minist Educ,Jilin Ginseng Acad, Changchun 130117, Jilin, Peoples R China.
   [Zhang, He] Changchun Univ Chinese Med, Affiliated Hosp, Res Ctr Tradit Chinese Med, Changchun, Peoples R China.
   [Hu, Cheng] Jilin Med Univ, Coll Lab Med, Jilin, Jilin, Peoples R China.
   [Xue, Jiaojiao; Jin, Di; Tian, Lulu] Changchun Univ Chinese Med, Coll Chinese Med, Changchun, Peoples R China.
C3 Ministry of Education - China; Changchun University of Chinese Medicine;
   Changchun University of Chinese Medicine; Jilin Medical University;
   Changchun University of Chinese Medicine
RP Li, XY; Qi, WX (corresponding author), Changchun Univ Chinese Med, Jilin Prov Key Lab Biomacromol Chinese Med, Key Lab Act Subst & Biol Mech Ginseng Efficacy, Minist Educ,Jilin Ginseng Acad, Changchun 130117, Jilin, Peoples R China.
EM xiangyan_li1981@163.com; qiwenxiu0517@163.com
RI Zhang, He/GYD-7125-2022; Li, Xiangyan/JDW-4460-2023
OI Li, Xiangyan/0000-0001-6780-6314; Zhang, He/0000-0002-2891-8687
FU National Key Research and Development Program of China [2017YFC1702103];
   National Natural Science Foundation of China [U19A2013]; Science and
   Technology Development Plan Project of Jilin Province [202002053JC]
FX National Key Research and Development Program of China, Grant/Award
   Number: 2017YFC1702103; National Natural Science Foundation of China,
   Grant/Award Number: U19A2013; The Science and Technology Development
   Plan Project of Jilin Province, Grant/Award Number: 202002053JC
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NR 123
TC 12
Z9 14
U1 2
U2 35
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0951-418X
EI 1099-1573
J9 PHYTOTHER RES
JI Phytother. Res.
PD FEB
PY 2022
VL 36
IS 2
BP 857
EP 872
DI 10.1002/ptr.7369
EA JAN 2022
PG 16
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA ZA1QU
UT WOS:000742169900001
PM 35026867
DA 2025-06-11
ER

PT J
AU Nati, M
   Chung, KJ
   Chavakis, T
AF Nati, Marina
   Chung, Kyoung-Jin
   Chavakis, Triantafyllos
TI The Role of Innate Immune Cells in Nonalcoholic Fatty Liver Disease
SO JOURNAL OF INNATE IMMUNITY
LA English
DT Review
DE Inflammation; Macrophages; Neutrophils; Non-alcoholic fatty liver
   disease
ID NECROSIS-FACTOR-ALPHA; INDUCED HEPATIC STEATOSIS; CROWN-LIKE STRUCTURES;
   KUPFFER CELLS; NEUTROPHIL ELASTASE; EARLY-STAGE; RECEPTOR 4; CHOLESTEROL
   CRYSTALS; OXIDATIVE STRESS; STELLATE CELLS
AB Nonalcoholic fatty liver disease (NAFLD) is a very common hepatic pathology featuring steatosis and is linked to obesity and related conditions, such as the metabolic syndrome. When hepatic steatosis is accompanied by inflammation, the disorder is defined as nonalcoholic steatohepatitis (NASH), which in turn can progress toward fibrosis development that can ultimately result in cirrhosis. Cells of innate immunity, such as neutrophils or macrophages, are central regulators of NASH-related inflammation. Recent studies utilizing new experimental technologies, such as single-cell RNA sequencing, have revealed substantial heterogeneity within the macrophage populations of the liver, suggesting distinct functions of liver-resident Kupffer cells and recruited monocyte-derived macrophages with regards to regulation of liver inflammation and progression of NASH pathogenesis. Herein, we discuss recent developments concerning the function of innate immune cell subsets in NAFLD and NASH.
C1 [Nati, Marina; Chung, Kyoung-Jin; Chavakis, Triantafyllos] Tech Univ Dresden, Univ Hosp, Inst Clin Chem & Lab Med, Dresden, Germany.
   [Nati, Marina; Chung, Kyoung-Jin; Chavakis, Triantafyllos] Tech Univ Dresden, Fac Med Carl Gustav Carus, Dresden, Germany.
   [Nati, Marina; Chavakis, Triantafyllos] Tech Univ Dresden, Univ Hosp, Helmholtz Ctr Munich, Paul Langerhans Inst Dresden, Dresden, Germany.
   [Nati, Marina; Chavakis, Triantafyllos] German Ctr Diabet Res DZD, Neuherberg, Germany.
C3 Technische Universitat Dresden; Carl Gustav Carus University Hospital;
   Technische Universitat Dresden; Helmholtz Association; Helmholtz-Center
   Munich - German Research Center for Environmental Health; Technische
   Universitat Dresden; Carl Gustav Carus University Hospital; German
   Center for Diabetes Research (DZD)
RP Nati, M; Chavakis, T (corresponding author), Tech Univ Dresden, Univ Hosp, Inst Clin Chem & Lab Med, Dresden, Germany.; Nati, M; Chavakis, T (corresponding author), Tech Univ Dresden, Fac Med Carl Gustav Carus, Dresden, Germany.; Nati, M; Chavakis, T (corresponding author), Tech Univ Dresden, Univ Hosp, Helmholtz Ctr Munich, Paul Langerhans Inst Dresden, Dresden, Germany.; Nati, M; Chavakis, T (corresponding author), German Ctr Diabet Res DZD, Neuherberg, Germany.
EM marina.nati@uniklinikum-dresden.de;
   triantafyllos.chavakis@uniklinikum-dresden.de
RI Chavakis, Triantafyllos/ABE-8845-2020
FU European Research Council (ERC); German Research Foundation (DFG);
   National Institute of Dental and Craniofacial Research/National
   Institutes of Health (NIDCR/NIH); German Ministry of Research and
   Education (BMBF); Else Kroner Fresenius Center for Digital Health
   Dresden
FX T.C. is supported by funds from the European Research Council (ERC), the
   German Research Foundation (DFG), the National Institute of Dental and
   Craniofacial Research/National Institutes of Health (NIDCR/NIH), the
   German Ministry of Research and Education (BMBF), and the Else Kroner
   Fresenius Center for Digital Health Dresden.
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NR 154
TC 54
Z9 55
U1 5
U2 34
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1662-811X
EI 1662-8128
J9 J INNATE IMMUN
JI J. Innate Immun.
PD JAN
PY 2022
VL 14
IS 1
BP 31
EP 41
DI 10.1159/000518407
EA AUG 2021
PG 11
WC Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology
GA YI3GN
UT WOS:000688554900001
PM 34515137
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Ou, XH
   Zhu, CC
   Sun, SC
AF Ou, Xiang-Hong
   Zhu, Cheng-Cheng
   Sun, Shao-Chen
TI Effects of obesity and diabetes on the epigenetic modification of
   mammalian gametes
SO JOURNAL OF CELLULAR PHYSIOLOGY
LA English
DT Review
DE diabetes; epigenetic modification; obesity; oocyte; sperm
ID HIGH-FAT-DIET; DNA METHYLATION; MOUSE SPERMATOGENESIS; METABOLIC
   SYNDROME; PATERNAL OBESITY; OXIDATIVE STRESS; HISTONE; OOCYTE;
   INHERITANCE; EXPRESSION
AB Obesity and diabetes are closely associated with numerous reproductive disorders, including termination of ovulation, irregular menstruation, low fertility, abortion, and risky pregnancy, which are now regarded as global health problems. Paternal/maternal obesity and diabetes can also be transmitted to the subsequent generation via gametes, suggesting the association of epigenetic inheritance with obesity and diabetes, particularly for its effects on offspring. Recent studies indicate that both obesity and diabetes change DNA and histone methylation levels, histone acetylation, and noncoding RNAs such as microRNAs (miRNAs) in oocytes and sperm. Several important genes, such as PPAR-alpha, Igf2, H19, Fyn, Stella, Sirt3, Sirt6, and Peg3 as well as miRNAs, such as let-7c, reportedly participate in the regulation of epigenetic modifications in mammalian gametes. This review summarizes the recent progress that links obesity/diabetes and reproductive disorders from the perspective of gamete epigenetic modifications.
C1 [Ou, Xiang-Hong] Guangdong Second Prov Gen Hosp, Fertil Preservat Lab, Reprod Med Ctr, Guangzhou, Guangdong, Peoples R China.
   [Zhu, Cheng-Cheng; Sun, Shao-Chen] Nanjing Agr Univ, Coll Anim Sci & Technol, Nanjing 210095, Jiangsu, Peoples R China.
   [Zhu, Cheng-Cheng] Nanjing Police Dog Inst, Minist Publ Secur, Nanjing, Jiangsu, Peoples R China.
C3 Nanjing Agricultural University; Ministry of Public Security (China)
RP Sun, SC (corresponding author), Nanjing Agr Univ, Coll Anim Sci & Technol, Nanjing 210095, Jiangsu, Peoples R China.
EM sunsc@njau.edu.cn
OI Sun, Shao-Chen/0000-0001-5060-1742; Ou, Xiang-Hong/0000-0001-9047-1612
FU National Natural Science Foundation of China [31571547, 31622055];
   Fundamental Research Funds for the Central Universities [KJYQ201701,
   KYTZ201602]
FX National Natural Science Foundation of China, Grant/Award Numbers:
   31571547, 31622055; Fundamental Research Funds for the Central
   Universities, Grant/Award Numbers: KJYQ201701, KYTZ201602
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SC Cell Biology; Physiology
GA HM2QU
UT WOS:000459314500018
PM 30536398
DA 2025-06-11
ER

PT J
AU Ascensao, A
   Martins, MJ
   Santos-Alves, E
   Gonçalves, IO
   Portincasa, P
   Oliveira, PJ
   Magalhaes, J
AF Ascensao, Antonio
   Martins, Maria J.
   Santos-Alves, Estela
   Goncalves, Ines O.
   Portincasa, Piero
   Oliveira, Paulo J.
   Magalhaes, Jose
TI Modulation of hepatic redox status and mitochondrial metabolism by
   exercise: Therapeutic strategy for liver diseases
SO MITOCHONDRION
LA English
DT Review
DE Physical activity; Liver disease; Bioenergetics; Oxidative damage
ID PERMEABILITY TRANSITION PORE; VITAMIN-E; OXIDATIVE STRESS;
   SKELETAL-MUSCLE; NITRIC-OXIDE; RAT-LIVER; GLUTATHIONE HOMEOSTASIS;
   EXHAUSTIVE EXERCISE; RADICAL GENERATION; MODERATE EXERCISE
AB Liver steatosis (non-alcoholic fatty liver disease, NAFLD) is deemed as the hepatic face of the metabolic syndrome, with both physical inactivity and hypercaloric/unbalanced diet, together with increasing age playing a role as predisposing factors. Consequently, one of the most effective strategies used to counteract this scenario is physical exercise.
   Given the importance of redox signaling in cellular remodeling, in which mitochondria are closely implicated along with important roles on substrate oxidation, here we briefly review the effects of both acute and chronic forms of physical exercise on the modulation of hepatic redox state, highlighting the relevance of mitochondrial metabolism and function in the induction of liver phenotypes that antagonize metabolic alterations associated with liver metabolic diseases. (C) 2013 Elsevier B.V. and Mitochondria Research Society. All rights reserved.
C1 [Ascensao, Antonio; Santos-Alves, Estela; Goncalves, Ines O.; Magalhaes, Jose] Univ Porto, Res Ctr Phys Act Hlth & Leisure, Fac Sport, P-4200450 Oporto, Portugal.
   [Martins, Maria J.] Univ Porto, Fac Med, Dept Biochem FCT U38, P-4200450 Oporto, Portugal.
   [Portincasa, Piero] Univ Med Sch, Dept Biomed Sci & Human Oncol, Bari, Italy.
   [Oliveira, Paulo J.] Univ Coimbra, CNC Ctr Neurosci & Cell Biol, P-3000 Coimbra, Portugal.
C3 Universidade do Porto; Universidade do Porto; Universidade de Coimbra
RP Ascensao, A (corresponding author), Univ Porto, Res Ctr Phys Act Hlth & Leisure, Fac Sport, Rua Dr Placido Costa 91, P-4200450 Oporto, Portugal.
EM aascensao@fade.up.pt
RI Santos-Alves, Estela/AAY-1349-2021; Goncalves, Ines/AAM-1256-2021;
   Oliveira, Paulo/AAQ-8943-2020; Martins, Maria João/ABC-8271-2021;
   portincasa, piero/J-7245-2018; Oliveira, Paulo/H-1980-2011; Magalhaes,
   Jose/B-6991-2009; Ascensao, Antonio/I-6171-2013
OI portincasa, piero/0000-0001-5359-1471; Oliveira,
   Paulo/0000-0002-5201-9948; Magalhaes, Jose/0000-0003-4808-8374;
   Ascensao, Antonio/0000-0001-5269-0857; Alves,
   Estela/0000-0001-8084-0859; Goncalves, Ines/0000-0001-8702-2883;
   Martins, Maria Joao/0000-0002-3560-3261
FU Portuguese Foundation for Science and Technology (FCT)
   [SFRH/BPD/4225/2007, SFRH/BD/2352/2009, SFRH/BPD/66935/2009];
   COMPETE/FEDER/National funds; FCT
   [PTDC/DES/113580/2009-FCOMP-01-0124-FEDER-014705]; Research Centre in
   Physical Activity, Health and Leisure UID [PEst-OE/SAU/UI0617/2011]
FX AA (SFRH/BPD/4225/2007), JOG (SFRH/BD/2352/2009) and JM
   (SFRH/BPD/66935/2009) are supported by grants from the Portuguese
   Foundation for Science and Technology (FCT), co-funded by
   COMPETE/FEDER/National funds. The present work was supported by research
   grants from the FCT (PTDC/DES/113580/2009-FCOMP-01-0124-FEDER-014705) to
   Antonio Ascensao, and Research Centre in Physical Activity, Health and
   Leisure UI&D (PEst-OE/SAU/UI0617/2011).
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NR 93
TC 25
Z9 27
U1 1
U2 21
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 1567-7249
EI 1872-8278
J9 MITOCHONDRION
JI Mitochondrion
PD NOV
PY 2013
VL 13
IS 6
BP 862
EP 870
DI 10.1016/j.mito.2013.07.002
PG 9
WC Cell Biology; Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Genetics & Heredity
GA 255ZY
UT WOS:000327280500039
PM 23880173
DA 2025-06-11
ER

PT J
AU Tran, A
   Gual, P
AF Tran, Albert
   Gual, Philippe
TI Non-alcoholic steatohepatitis in morbidly obese patients
SO CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY
LA English
DT Review
ID C-REACTIVE PROTEIN; FATTY LIVER-DISEASE; NF-KAPPA-B; WHITE
   ADIPOSE-TISSUE; REGULATORY T-CELLS; INSULIN-RESISTANCE; METABOLIC
   SYNDROME; HEPATIC STEATOSIS; MACROPHAGE INFILTRATION; OSTEOPONTIN
   EXPRESSION
AB The hepatic complications of morbid obesity range from steatosis to steatohepatitis (Non-alcoholic steatohepatitis [NASH]), fibrosis, cirrhosis and finally hepatocellular carcinoma. The pathophysiological mechanisms of the progression of a normal liver to a liver showing steatosis and then steatohepatitis are complex, including, per se, insulin-resistance, iron accumulation, oxidative stress and hepatocyte death. An imbalance in anti-and pro-inflammatory factors may be the trigger. These factors can originate from intra-or extrahepatic sites, particularly the adipose tissue and the gut. This review will provide insight into the current diagnosis and understanding of hepatic inflammation including non-invasive markers of NASH (markers of hepatocyte death), intrahepatic mechanisms (regulation of the immune and inflammatory response, hepatocellular iron deposition, hepatocyte death) and extrahepatic factors (from adipose tissue and gut) in morbidly obese patients. (C) 2012 Elsevier Masson SAS. All rights reserved.
C1 [Tran, Albert; Gual, Philippe] INSERM, Team Hepat Complicat Obes 8, U1065, F-06204 Nice 03, France.
   [Tran, Albert; Gual, Philippe] Univ Nice Sophia Antipolis, Fac Med, F-06189 Nice, France.
   [Tran, Albert; Gual, Philippe] Ctr Hosp Univ Nice, Hop Archet, Dept Digestif, Nice, France.
C3 Institut National de la Sante et de la Recherche Medicale (Inserm);
   Universite Cote d'Azur; CHU Nice
RP Gual, P (corresponding author), INSERM, Team Hepat Complicat Obes 8, U1065, Batiment Univ Archimed,151 Route St Antoine Gines, F-06204 Nice 03, France.
EM gual@unice.fr
RI Gual, Philippe/P-9833-2019; Gual, Philippe/M-8787-2017
OI Albert, TRAN/0000-0003-0003-5361; Gual, Philippe/0000-0001-7393-8356
FU Inserm (France); University of Nice; Programme Hospitalier de recherche
   clinique (Centre hospitalier universitaire of Nice); Association
   francaise pour l'etude du foie (AFEF)/Schering-Plough; Societe
   Francophone du Diabete/BMS; Centre hospitalier universitaire of Nice
FX This work was supported by grants from Inserm (France), the University
   of Nice, the Programme Hospitalier de recherche clinique (Centre
   hospitalier universitaire of Nice), and charities (Association francaise
   pour l'etude du foie (AFEF)/Schering-Plough and Societe Francophone du
   Diabete/BMS to PG). PG is a recipient of an Interface Grant from the
   Centre hospitalier universitaire of Nice.
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NR 152
TC 27
Z9 28
U1 0
U2 8
PU ELSEVIER MASSON, CORPORATION OFFICE
PI PARIS
PA 65 CAMILLE DESMOULINS CS50083 ISSY-LES-MOULINEAUX, 92442 PARIS, FRANCE
SN 2210-7401
EI 2210-741X
J9 CLIN RES HEPATOL GAS
JI Clin. Res. Hepatol. Gastroenterol.
PD FEB
PY 2013
VL 37
IS 1
BP 17
EP 29
DI 10.1016/j.clinre.2012.07.005
PG 13
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 234CH
UT WOS:000325616800015
PM 23347840
DA 2025-06-11
ER

PT J
AU González-Chávez, A
   Elizondo-Argueta, S
   Gutiérrez-Reyes, G
   León-Pedroza, JI
AF Gonzalez-Chavez, Antonio
   Elizondo-Argueta, Sandra
   Gutierrez-Reyes, Gabriela
   Israel Leon-Pedroza, Jose
TI Pathophysiological implications between chronic inflammation and the
   development of diabetes and obesity
SO CIRUGIA Y CIRUJANOS
LA English
DT Article
DE chronic inflammation; diabetes; obesity; innate immunity
ID THIOREDOXIN-INTERACTING PROTEIN; TOLL-LIKE RECEPTORS; ADIPOSE-TISSUE;
   ENDOPLASMIC-RETICULUM; METABOLIC SYNDROME; PPAR-GAMMA; ENDOTHELIAL
   DYSFUNCTION; OXIDATIVE STRESS; ACTIVATION; GLUCOSE
AB The different theories about the mechanisms involved in the development of metabolic disease and its complications converge in the presence of an etiologic chronic proinflammatory state. Chronic inflammation is, at present, the central pathophysiological mechanism involved in the genesis of metabolic diseases. The multiple interactions between the immune system, adipose tissue, the vascular wall and the pancreas are the issues addressed in this review, focusing on specific intracellular and molecular aspects that may become new therapeutic targets. These lead to a proinflammatory, prothrombotic state as well as to proapoptotic endothelial damage that allows the development of atherosclerosis and, consequently, cardiovascular disease. The multiple immunopathological processes associated with the etiology and pathophysiology of different chronic diseases is still in the process of being fully elucidated, allowing the development of new therapeutic targets.
C1 [Gonzalez-Chavez, Antonio; Israel Leon-Pedroza, Jose] Hosp Gen Mexico City, Med Interna Serv, Unidad 308, Secretaria Salud, Mexico City 06726, DF, Mexico.
   [Elizondo-Argueta, Sandra] Hosp Gen Naval Alta Especialidad, Serv Terapia Intens, Secretaria Marina Armada Mexico, Mexico City, DF, Mexico.
   [Gutierrez-Reyes, Gabriela] Univ Nacl Autonoma Mexico, Fac Med, Dept Expt Med, Lab HIPAM, Mexico City 04510, DF, Mexico.
C3 Hospital General de Mexico; Universidad Nacional Autonoma de Mexico
RP González-Chávez, A (corresponding author), Hosp Gen Mexico City, Med Interna Serv, Unidad 308, Secretaria Salud, Dr Balmis 148, Mexico City 06726, DF, Mexico.
EM antglez51@yahoo.com.mx
RI ; Leon-Pedroza, Jose Israel/I-8523-2017
OI Elizondo Argueta, Sandra/0000-0003-4311-1416; Leon-Pedroza, Jose
   Israel/0000-0001-7750-7967
CR [Anonymous], SINDROME METABOLICO
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NR 50
TC 7
Z9 10
U1 0
U2 5
PU MEXICAN ACAD SURGERY
PI MEXICO D G
PA CENTRO MED NAC SIGLO XXI, EDIFICIO BLOQUE B, SOTANO, AVE CUAUHTEMOC NO
   330, MEXICO D G, 06700, MEXICO
SN 0009-7411
J9 CIR CIR
JI Cir. Cir.
PD MAR-APR
PY 2011
VL 79
IS 2
BP 190
EP 197
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 756TR
UT WOS:000290038100017
DA 2025-06-11
ER

PT J
AU Yamagishi, SI
   Matsui, T
   Kawaguchi, T
   Sata, M
AF Yamagishi, S. -I.
   Matsui, T.
   Kawaguchi, T.
   Sata, M.
TI Pathophysiological Role of Pigment Epithelium-Derived Factor (PEDF) in
   Hepatic Disorders
SO CURRENT MEDICINAL CHEMISTRY
LA English
DT Review
DE hepatic insulin resistance; oxidative stress; hepatocellular carcinoma;
   PEDF
ID GLYCATION END-PRODUCTS; NONALCOHOLIC FATTY LIVER; DIABETIC VASCULAR
   COMPLICATIONS; SUPPRESSING RAC-1 ACTIVATION; OXYGEN SPECIES GENERATION;
   C-REACTIVE PROTEIN; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   HEPATOCELLULAR-CARCINOMA; ANTIOXIDATIVE PROPERTIES
AB Pigment epithelium-derived factor (PEDF) is a glycoprotein that belongs to the superfamily of serine protease inhibitors with a potent neuronal differentiating activity. Recently, PEDF is found to be a highly effective inhibitor of pathological angiogenesis in both cell culture and animal models. Further, it has also been shown to have neuroprotective, anti-oxidative and anti-inflammatory properties, any of which could potentially be exploited as a therapeutic option for the treatment of cardiometabolic disorders, neurodegenerative disease and cancers. However, as far as we know, there are few comprehensive reviews to deal with the involvement of PEDF in hepatic disease. This article summarizes the pathophysiological role of PEDF for various liver diseases such as hepatic insulin resistance, alcoholic and nonalcoholic liver disease, and hepatocellular carcinoma, and its potential therapeutic implication in these devastating disorders.
C1 [Yamagishi, S. -I.; Matsui, T.] Kurume Univ, Sch Med, Dept Pathophysiol & Therapeut Diabet Vasc Complic, Kurume, Fukuoka 8300011, Japan.
   [Kawaguchi, T.; Sata, M.] Kurume Univ, Sch Med, Dept Digest Dis Informat & Res, Kurume, Fukuoka 8300011, Japan.
   [Kawaguchi, T.; Sata, M.] Kurume Univ, Sch Med, Dept Med, Kurume, Fukuoka 8300011, Japan.
C3 Kurume University; Kurume University; Kurume University
RP Yamagishi, SI (corresponding author), Kurume Univ, Sch Med, Dept Pathophysiol & Therapeut Diabet Vasc Complic, Kurume, Fukuoka 8300011, Japan.
EM shoichi@med.kurume-u.ac.jp
OI Matsui, Takanori/0000-0001-9506-7571
FU Ministry of Education, Culture, Sports, Science and Technology, Japan
FX This work was supported in part by Grants of Collaboration with Venture
   Companies Project from the Ministry of Education, Culture, Sports,
   Science and Technology, Japan (S Yamagishi).
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NR 66
TC 17
Z9 19
U1 0
U2 7
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 0929-8673
EI 1875-533X
J9 CURR MED CHEM
JI Curr. Med. Chem.
PD JUL
PY 2010
VL 17
IS 19
BP 1995
EP 2000
DI 10.2174/092986710791233670
PG 6
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Pharmacology &
   Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
GA 599JY
UT WOS:000277909300001
PM 20423314
DA 2025-06-11
ER

PT J
AU Lewis, JR
   Mohanty, SR
AF Lewis, Jeffrey R.
   Mohanty, Smruti R.
TI Nonalcoholic Fatty Liver Disease: A Review and Update
SO DIGESTIVE DISEASES AND SCIENCES
LA English
DT Review
DE Steatosis; Steatohepatitis; Cirrhosis
ID PLACEBO-CONTROLLED TRIAL; MACROVESICULAR HEPATIC STEATOSIS; DOPPLER
   PERFUSION INDEX; NECROSIS-FACTOR-ALPHA; INSULIN-RESISTANCE; VITAMIN-E;
   URSODEOXYCHOLIC ACID; NATURAL-HISTORY; RISK-FACTORS; WEIGHT-LOSS
AB The spectrum of nonalcoholic fatty liver disease (NAFLD) ranges from asymptomatic steatosis to nonalcoholic steatohepatitis (NASH) and cirrhosis. Hepatic steatosis occurs when free fatty acids, released in the setting of insulin resistance and the metabolic syndrome, are taken up by the liver. Additional biochemical insults, including oxidative stress, upregulation of inflammatory mediators, and dysregulated apoptosis, can result in inflammation (producing NASH) and fibrosis. Noninvasive methods (e.g., abdominal ultrasonography) are safe ways to support a diagnosis of hepatic steatosis, but advanced liver histopathologic findings including NASH and fibrosis cannot be identified without pursuing liver biopsy. Recent advances in serologic and imaging methods aim to determine severity of inflammation and fibrosis noninvasively. Currently, therapeutic options for NAFLD are limited to medications that reduce risk factors, but the future holds promise for therapies that might slow the progression of this increasingly prevalent disorder.
C1 [Mohanty, Smruti R.] Univ Chicago, Gastroenterol Sect, Ctr Liver Dis, Chicago, IL 60637 USA.
   [Lewis, Jeffrey R.; Mohanty, Smruti R.] Univ Chicago, Dept Med, Ctr Liver Dis, Chicago, IL 60637 USA.
C3 University of Chicago; University of Chicago
RP Mohanty, SR (corresponding author), Univ Chicago, Gastroenterol Sect, Ctr Liver Dis, 5841 S Maryland Ave,MC 7120, Chicago, IL 60637 USA.
EM Jeffrey.lewis@uchospitals.edu; smohanty@medicine.bsd.uchicago.edu
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   2008, PHASE 1 PHARMACOKINE
   2004, DETECTION EVALUATION
   2008, RECOMBINANT LEPTIN T
NR 203
TC 251
Z9 299
U1 0
U2 51
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0163-2116
EI 1573-2568
J9 DIGEST DIS SCI
JI Dig. Dis. Sci.
PD MAR
PY 2010
VL 55
IS 3
BP 560
EP 578
DI 10.1007/s10620-009-1081-0
PG 19
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 556UD
UT WOS:000274617500003
PM 20101463
DA 2025-06-11
ER

PT J
AU de Abreu, AP
   Drager, LF
   Almeida, MQ
   Bortolotto, LA
   Lopes, HF
AF de Abreu, Andrea Pio
   Drager, Luciano Ferreira
   Almeida, Madson Queiroz
   Bortolotto, Luiz Aparecido
   Lopes, Heno Ferreira
TI Cardiovascular-kidney-metabolic Syndrome: a current and urgent concept
SO JORNAL BRASILEIRO DE NEFROLOGIA
LA English
DT Article
DE Cardiovascular Diseases; Renal Insufficiency, Chronic; Obesity; Chronic
   Inflammation; Oxidative Stress
AB The concept of cardiovascular-kidneymetabolic health is based on the idea of a multifaceted interaction among several cardiovascular, renal, and metabolic factors. Alterations in this complex interaction have a significant impact on morbidity and mortality. The ramifications of poor cardiovascularkidney-metabolic health are far-reaching, with a notable clinical impact. A considerable proportion of the population is affected by precarious cardiovascular, renal, and metabolic health, and individuals with adverse social determinants of health endure an even greater burden. To this end, it is essential to develop an approach that incorporates metabolic staging and prioritizes lifelong prevention. Equally imperative is integrating the social determinants of health into care models for Cardiovascular-kidneymetabolic syndrome, facilitating patientcentered interdisciplinary care. The provides guidelines on the definition, staging, paradigms, and holistic approaches to the management of patients with this syndrome. Furthermore, it offers a comprehensive framework for effectively and equitably improving the cardiovascular, kidney, and metabolic health of the population.
C1 [de Abreu, Andrea Pio; Drager, Luciano Ferreira] Univ Sao Paulo, Hosp Clin, Fac Med, Dept Nefrol, Sao Paulo, SP, Brazil.
   [Drager, Luciano Ferreira; Bortolotto, Luiz Aparecido; Lopes, Heno Ferreira] Univ Sao Paulo, Hosp Clin, Fac Med, Unidade Hipertensao,Inst Coracao, Sao Paulo, SP, Brazil.
   [Almeida, Madson Queiroz] Univ Sao Paulo, Hosp Clin, Fac Med, Dept Endocrinol & Metabol, Sao Paulo, SP, Brazil.
C3 Universidade de Sao Paulo; Universidade de Sao Paulo; Universidade de
   Sao Paulo
RP de Abreu, AP (corresponding author), Univ Sao Paulo, Hosp Clin, Fac Med, Dept Nefrol, Sao Paulo, SP, Brazil.
EM andrea.pabreu@hc.fm.usp.br
RI Drager, Luciano/A-1535-2014; Almeida, Madson/C-9579-2012; Bortolotto,
   Luiz/S-1940-2017
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NR 20
TC 0
Z9 0
U1 0
U2 0
PU SOC BRASILEIRA NEFROLOGIA
PI SAO PAULO
PA RUA MAVCHADO BITTENCOURT, 205-5 ANDAR-CONJ 53-VILA CLEMENTINO, SAO
   PAULO, 00000, BRAZIL
SN 0101-2800
EI 2175-8239
J9 J BRAS NEFROL
JI J. Bras. Nefrol.
PY 2025
VL 47
IS 2
AR e20240277
DI 10.1590/2175-8239-JBN-2024-0277en
PG 8
WC Urology & Nephrology
WE Emerging Sources Citation Index (ESCI)
SC Urology & Nephrology
GA 2WX2X
UT WOS:001493261200001
PM 40393033
DA 2025-06-11
ER

PT J
AU Obika, M
   Noguchi, H
AF Obika, Mikako
   Noguchi, Hirofumi
TI Diagnosis and Evaluation of Nonalcoholic Fatty Liver Disease
SO EXPERIMENTAL DIABETES RESEARCH
LA English
DT Review
ID CHRONIC HEPATITIS-C; SERUM THIOREDOXIN LEVELS; NECROSIS-FACTOR-ALPHA;
   CARDIOVASCULAR-DISEASE; BIOCHEMICAL MARKERS; INSULIN-RESISTANCE;
   METABOLIC SYNDROME; OXIDATIVE STRESS; REACTIVE PROTEIN; SCORING SYSTEM
AB Nonalcoholic fatty liver disease (NAFLD) is the most common cause of elevated liver function tests results, after the commonly investigated causes have been excluded, and frequently coexists with type 2 diabetes mellitus (T2DM) because the conditions have common risk factors. As both T2DM and NAFLD are related to adverse outcomes of the other, diagnosis and valuation of fatty liver is an important part of the management of diabetes. Although noninvasive methods, such as biomarkers, panel markers, and imaging, may support a diagnostic evaluation of NAFLD patients, accurate histopathological findings cannot be achieved without a liver biopsy. As it is important to know whether steatohepatitis and liver fibrosis are present for the management of NAFLD, liver biopsy remains the gold standard for NAFLD diagnosis and evaluation. Therefore, new investigations of the pathogenesis of NAFLD are necessary to develop useful biomarkers that could provide a reliable noninvasive alternative to liver biopsy.
C1 [Obika, Mikako] Okayama Univ Hosp, Dept Gen Internal Med, Okayama 7008558, Japan.
   [Noguchi, Hirofumi] Okayama Univ, Dept Surg Gastroenterol, Grad Sch Med Dent & Pharmaceut Sci, Okayama 7008558, Japan.
C3 Okayama University; Okayama University
RP Obika, M (corresponding author), Okayama Univ Hosp, Dept Gen Internal Med, 2-5-1 Shikata Cho, Okayama 7008558, Japan.
EM obika-m@cc.okayama-u.ac.jp
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NR 158
TC 171
Z9 189
U1 0
U2 22
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1687-5214
EI 1687-5303
J9 EXP DIABETES RES
JI Exp. Diabetes Res.
PY 2012
AR 145754
DI 10.1155/2012/145754
PG 12
WC Endocrinology & Metabolism; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Research & Experimental Medicine
GA 868WM
UT WOS:000298557000001
PM 22110476
OA Green Submitted, Green Published, Green Accepted, gold
DA 2025-06-11
ER

PT J
AU Stanfel, MN
   Shamieh, LS
   Kaeberlein, M
   Kennedy, BK
AF Stanfel, Monique N.
   Shamieh, Lara S.
   Kaeberlein, Matt
   Kennedy, Brian K.
TI The TOR pathway comes of age
SO BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
LA English
DT Review
DE Aging; TOR; S6 kinase; Neurodegeneration; Metabolic syndrome;
   Cardiovascular disease; Dietary restriction
ID LIFE-SPAN EXTENSION; ACTIVATED PROTEIN-KINASE; DIETARY RESTRICTION;
   CALORIC RESTRICTION; MAMMALIAN TARGET; S6 KINASE; SIGNALING PATHWAY;
   CARDIAC-HYPERTROPHY; UP-REGULATION; INCREASED RESPIRATION
AB Studies in a variety of model organisms indicate that nutrient signaling is tightly coupled to longevity. In nutrient replete conditions, organisms develop, grow, and age quickly. When nutrients become sparse as with dietary restriction, growth and development decline, stress response pathways become induced and organisms live longer. Considerable effort has been devoted to understanding the molecular events mediating lifespan extension by dietary restriction. One central focus has been on nutrient-responsive signal transduction pathways including insulin/IGF-1, AMP kinase, protein kinase A and the TOR pathway. Here we describe the increasingly prominent links between TOR signaling and aging in invertebrates. Longevity studies in mammals are not published to date. Instead, we highlight studies in mouse models, which indicate that dampening the TOR pathway leads to widespread protection from an array of age-related diseases. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Shamieh, Lara S.; Kaeberlein, Matt] Univ Washington, Dept Pathol, Seattle, WA 98195 USA.
   [Stanfel, Monique N.; Kennedy, Brian K.] Univ Washington, Dept Biochem, Seattle, WA 98195 USA.
C3 University of Washington; University of Washington Seattle; University
   of Washington; University of Washington Seattle
RP Kaeberlein, M (corresponding author), Univ Washington, Dept Pathol, Seattle, WA 98195 USA.
EM bkenn@u.washington.edu
OI Kennedy, Brian/0000-0002-5754-1874; Kaeberlein, Matt/0000-0002-1311-3421
FU NIA [R01AG033373-01A1, R01AG025549-04, R01AG031108]; NIH [T32AG000057]
FX Research on TOR and aging in the Kaeberlein and Kennedy groups is
   supported by NIA R01AG033373-01A1 to B.K.K., R01AG025549-04 to B.K.K.
   and M.K., and R01AG031108 to M.K. M.N.S. and LS.S. are supported by the
   NIH training grant T32AG000057.
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NR 151
TC 271
Z9 322
U1 2
U2 54
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0304-4165
EI 1872-8006
J9 BBA-GEN SUBJECTS
JI Biochim. Biophys. Acta-Gen. Subj.
PD OCT
PY 2009
VL 1790
IS 10
BP 1067
EP 1074
DI 10.1016/j.bbagen.2009.06.007
PG 8
WC Biochemistry & Molecular Biology; Biophysics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics
GA 503EO
UT WOS:000270516100014
PM 19539012
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Sevenoaks, MJ
   Stockley, RA
AF Sevenoaks, Martin J.
   Stockley, Robert A.
TI Chronic Obstructive Pulmonary Disease, inflammation and co-morbidity - a
   common inflammatory phenotype?
SO RESPIRATORY RESEARCH
LA English
DT Article
ID NECROSIS-FACTOR-ALPHA; REACTIVE PROTEIN; SYSTEMIC INFLAMMATION;
   OXIDATIVE STRESS; INSULIN-RESISTANCE; TNF-ALPHA; ACUTE EXACERBATIONS;
   PROVISIONAL REPORT; METABOLIC SYNDROME; DIABETES-MELLITUS
AB Chronic Obstructive Pulmonary Disease ( COPD) is and will remain a major cause of morbidity and mortality worldwide. The severity of airflow obstruction is known to relate to overall health status and mortality. However, even allowing for common aetiological factors, a link has been identified between COPD and other systemic diseases such as cardiovascular disease, diabetes and osteoporosis.
   COPD is known to be an inflammatory condition and neutrophil elastase has long been considered a significant mediator of the disease. Pro-inflammatory cytokines, in particular TNF-alpha ( Tumour Necrosis Factor alpha), may be the driving force behind the disease process. However, the roles of inflammation and these pro-inflammatory cytokines may extend beyond the lungs and play a part in the systemic effects of the disease and associated co-morbidities. This article describes the mechanisms involved and proposes a common inflammatory TNF-alpha phenotype that may, in part, account for the associations.
C1 Queen Elizabeth Hosp, Dept Med, Birmingham B15 2TH, W Midlands, England.
C3 University of Birmingham
RP Stockley, RA (corresponding author), Queen Elizabeth Hosp, Dept Med, Birmingham B15 2TH, W Midlands, England.
EM martin.sevenoaks@uhb.nhs.uk; r.a.stockley@bham.ac.uk
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NR 86
TC 188
Z9 219
U1 1
U2 5
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1465-993X
J9 RESP RES
JI Respir. Res.
PD MAY 2
PY 2006
VL 7
AR 70
DI 10.1186/1465-9921-7-70
PG 9
WC Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Respiratory System
GA 054WB
UT WOS:000238408200001
PM 16669999
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Sisljagic, D
   Blazetic, S
   Heffer, M
   Delac, MV
   Muller, A
AF Sisljagic, Dina
   Blazetic, Senka
   Heffer, Marija
   Delac, Mihaela Vranjes
   Muller, Andrijana
TI The Interplay of Uterine Health and Obesity: A Comprehensive Review
SO BIOMEDICINES
LA English
DT Review
DE uterus; obesity; insulin resistance; leptin resistance; female
   reproductive health; metabolic syndrome; adipokines; endometrial
   function; fertility; therapeutic interventions
ID ENDOMETRIAL HYPERPLASIA; LEPTIN SENSITIVITY; INSULIN-RESISTANCE;
   SIGNALING PATHWAY; RAT MODEL; PREGNANCY; WEIGHT; WOMEN; ADIPOKINES;
   UTERUS
AB Uterine physiology encompasses the intricate processes governing the structure, function, and regulation of the uterus, a pivotal organ within the female reproductive system. The escalating prevalence of obesity has emerged as a significant global health issue, profoundly impacting various facets of well-being, including female reproductive health. These effects extend to uterine structure and function, influencing reproductive health outcomes in women. They encompass alterations in uterine morphology, disruptions in hormonal signaling, and inflammatory processes. Insulin and leptin, pivotal hormones regulating metabolism, energy balance, and reproductive function, play crucial roles in this context. Insulin chiefly governs glucose metabolism and storage, while leptin regulates appetite and energy expenditure. However, in obesity, resistance to both insulin and leptin can develop, impacting uterine function. Inflammation and oxidative stress further exacerbate the development of uterine dysfunction in obesity. Chronic low-grade inflammation and heightened oxidative stress, characteristic of obesity, contribute to metabolic disruptions and tissue damage, including within the uterus. Obesity significantly disrupts menstrual cycles, fertility, and pregnancy outcomes in women. The accumulation of excess adipose tissue disrupts hormonal equilibrium, disturbs ovarian function, and fosters metabolic irregularities, all of which detrimentally impact reproductive health.
C1 [Sisljagic, Dina; Muller, Andrijana] Univ Hosp Ctr Osijek, Clin Gynecol & Obstet, Osijek 31000, Croatia.
   [Sisljagic, Dina; Muller, Andrijana] Josip Juraj Strossmayer Univ Osijek, Fac Med, Dept Gynecol & Obstet, Osijek 31000, Croatia.
   [Blazetic, Senka] Josip Juraj Strossmayer Univ Osijek, Dept Biol, Osijek 31000, Croatia.
   [Heffer, Marija] Josip Juraj Strossmayer Univ Osijek, Sch Med, Dept Med Biol, Osijek 31000, Croatia.
   [Delac, Mihaela Vranjes] Univ Zagreb, Fac Vet Med, Zagreb 10000, Croatia.
C3 University of JJ Strossmayer Osijek; University of JJ Strossmayer
   Osijek; University of JJ Strossmayer Osijek; University of Zagreb
RP Blazetic, S (corresponding author), Josip Juraj Strossmayer Univ Osijek, Dept Biol, Osijek 31000, Croatia.
EM drdinasisljagic@yahoo.com; senka@biologija.unios.hr; mheffer@mefos.hr;
   mvranjes@vef.hr; andrijana.muller@gmail.com
RI Heffer, Marija/ABA-4694-2020
OI Heffer, Marija/0000-0001-6770-7359
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TC 1
Z9 1
U1 5
U2 5
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2227-9059
J9 BIOMEDICINES
JI Biomedicines
PD DEC
PY 2024
VL 12
IS 12
AR 2801
DI 10.3390/biomedicines12122801
PG 14
WC Biochemistry & Molecular Biology; Medicine, Research & Experimental;
   Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Research & Experimental Medicine;
   Pharmacology & Pharmacy
GA Q7R1S
UT WOS:001386594000001
PM 39767708
OA gold
DA 2025-06-11
ER

PT J
AU Xepapadaki, E
   Zvintzou, E
   Kalogeropoulou, C
   Filou, S
   Kypreos, KE
AF Xepapadaki, Eva
   Zvintzou, Evangelia
   Kalogeropoulou, Christina
   Filou, Serafoula
   Kypreos, Kyriakos E.
TI τhe Antioxidant Function of HDL in Atherosclerosis
SO ANGIOLOGY
LA English
DT Review
DE atherosclerosis; high-density lipoprotein; dyslipidemia; antioxidant;
   nutritional interventions
ID HIGH-DENSITY-LIPOPROTEIN; REVERSE CHOLESTEROL TRANSPORT; ELEVATED
   OXIDATIVE STRESS; LOW-LEVEL HYPERCHOLESTEROLEMIA; POMEGRANATE JUICE
   CONSUMPTION; B TYPE-I; NONHUMAN PRIMATE; METABOLIC SYNDROME; VITAMIN-E;
   PARAOXONASE-1 ACTIVITY
AB Atherosclerosis is a multistep process that progresses over a long period of time and displays a broad range of severity. In its final form, it manifests as a lesion of the intimal layer of the arterial wall. There is strong evidence supporting that oxidative stress contributes to coronary heart disease morbidity and mortality and antioxidant high-density lipoprotein (HDL) could have a beneficial role in the prevention and prognosis of the disease. Indeed, certain subspecies of HDL may act as natural antioxidants preventing oxidation of lipids on low-density lipoprotein (LDL) and biological membranes. The antioxidant function may be attributed to inhibition of synthesis or neutralization of free radicals and reactive oxygen species by HDL lipids and associated enzymes or transfer of oxidation prone lipids from LDL and biological membranes to HDL for catabolism. A limited number of clinical trials suggest that the increased antioxidant potential of HDL correlates with decreased risk for atherosclerosis. Some nutritional interventions to increase HDL antioxidant activity have been proposed with limited success so far. The limitations in measuring and understanding HDL antioxidant function in vivo are also discussed.
C1 [Xepapadaki, Eva; Zvintzou, Evangelia; Kalogeropoulou, Christina; Filou, Serafoula; Kypreos, Kyriakos E.] Univ Patras, Sch Med, Dept Pharmacol, Rio Achaias, TK, Greece.
C3 University of Patras
RP Kypreos, KE (corresponding author), Univ Patras, Sch Med, Dept Med, Pharmacol Lab, Rio Achaias 26500, TK, Greece.
EM kkypreos@med.upatras.gr
RI Zvintzou, Evangelia/KFT-3259-2024; KYPREOS, KYRIAKOS/AAN-4485-2020
OI Kypreos, Kyriakos/0000-0001-6784-2710; Xepapadaki,
   Eva/0000-0002-0903-2637
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NR 122
TC 35
Z9 39
U1 0
U2 18
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0003-3197
EI 1940-1574
J9 ANGIOLOGY
JI Angiology
PD FEB
PY 2020
VL 71
IS 2
BP 112
EP 121
DI 10.1177/0003319719854609
PG 10
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA JY6DN
UT WOS:000504503300003
PM 31185723
DA 2025-06-11
ER

PT J
AU Di Costanzo, A
   Angelico, R
AF Di Costanzo, Alfonso
   Angelico, Ruggero
TI Formulation Strategies for Enhancing the Bioavailability of Silymarin:
   The State of the Art
SO MOLECULES
LA English
DT Review
DE silymarin; silybin; nanoemulsion; solid lipid nanoparticles;
   nanostructured lipid carriers; liposome; polymeric particles;
   self-emulsifying delivery systems; enhanced bioavailability
ID NANOSTRUCTURED LIPID CARRIERS; DRUG-DELIVERY SYSTEMS; IN-VITRO
   EVALUATION; ORAL BIOAVAILABILITY; MULTIPLE COMPONENTS; MIXED MICELLES;
   MILK-THISTLE; LOADED NANOPARTICLES; OXIDATIVE STRESS; SOLID DISPERSION
AB Silymarin, a mixture of flavonolignan and flavonoid polyphenolic compounds extractable from milk thistle (Silybum marianum) seeds, has anti-oxidant, anti-inflammatory, anti-cancer and anti-viral activities potentially useful in the treatment of several liver disorders, such as chronic liver diseases, cirrhosis and hepatocellular carcinoma. Equally promising are the effects of silymarin in protecting the brain from the inflammatory and oxidative stress effects by which metabolic syndrome contributes to neurodegenerative diseases. However, although clinical trials have proved that silymarin is safe at high doses (>1500 mg/day) in humans, it suffers limiting factors such as low solubility in water (<50 g/mL), low bioavailability and poor intestinal absorption. To improve its bioavailability and provide a prolonged silymarin release at the site of absorption, the use of nanotechnological strategies appears to be a promising method to potentiate the therapeutic action and promote sustained release of the active herbal extract. The purpose of this study is to review the different nanostructured systems available in literature as delivery strategies to improve the absorption and bioavailability of silymarin.
C1 [Di Costanzo, Alfonso] Univ Molise, Ctr Res & Training Med Aging, Dept Med & Hlth Sci Vincenzo Tiberio, I-86100 Campobasso, Italy.
   [Angelico, Ruggero] Univ Molise, Dept Agr Environm & Food Sci DIAAA, I-86100 Campobasso, Italy.
C3 University of Molise; University of Molise
RP Angelico, R (corresponding author), Univ Molise, Dept Agr Environm & Food Sci DIAAA, I-86100 Campobasso, Italy.
EM alfonso.dicostanzo@unimol.it; angelico@unimol.it
RI Angelico, Ruggero/A-4492-2008; Di Costanzo, Alfonso/AFO-2800-2022
OI Di Costanzo, Alfonso/0000-0002-6138-5640; Angelico,
   Ruggero/0000-0002-0769-5680
FU Molise Region [149]
FX The APC was funded by the Molise Region (D.D. n. 149, 14/07/2016).
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NR 149
TC 137
Z9 141
U1 3
U2 25
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1420-3049
J9 MOLECULES
JI Molecules
PD JUN 1
PY 2019
VL 24
IS 11
AR 2155
DI 10.3390/molecules24112155
PG 29
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA IE8NT
UT WOS:000472631000128
PM 31181687
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Svistunov, AA
   Tarasov, VV
   Shakhmardanova, SA
   Sologova, SS
   Bagaturiya, ET
   Chubarev, VN
   Galenko-Yaroshevsky, PA
   Avila-Rodriguez, MF
   Barreto, GE
   Aliev, G
AF Svistunov, Andrey A.
   Tarasov, Vadim V.
   Shakhmardanova, Svetlana A.
   Sologova, Susanna S.
   Bagaturiya, Ekaterina T.
   Chubarev, Vladimir N.
   Galenko-Yaroshevsky, Pavel A.
   Fidel Avila-Rodriguez, Marco
   Barreto, George E.
   Aliev, Gjumrakch
TI Urotensin II: Molecular Mechanisms of Biological Activity
SO CURRENT PROTEIN & PEPTIDE SCIENCE
LA English
DT Review
DE Urotensin II; regulatory peptides; molecular targets of Urotensin II in
   cardiovascular; nervous; hormonal systems; stress; kidney; sexual
   function; cancer; G-protein-coupled receptors; drug design
ID TYPE-2 DIABETES-MELLITUS; AORTIC ADVENTITIAL FIBROBLASTS;
   SMOOTH-MUSCLE-CELLS; RECEPTOR ANTAGONIST; OXIDATIVE STRESS; CAROTID
   ATHEROSCLEROSIS; DEPENDENT VASODILATOR; CARDIAC FIBROSIS; PROGENITOR
   CELLS; CALCIUM-ENTRY
AB Urotensin II (UT II) is an important factor of cellular homeostasis. This regulatory peptide is involved in the pathophysiology of many disorders. For example, it plays an important role in the pathogenesis of acute and chronic diseases, stressful and adaptive reactions of the body, in the development of cardiovascular pathologies, metabolic syndrome, inflammation, liver cirrhosis, renal failure, diabetic nephropathy, reproductive dysfunction, progression of psychosomatic, psychoendocrinal and psychiatric disorders. In this concern, the involvement of UT II in the pathophysiology of many processes determines the perspectives for the development of blockers of urotensin receptors for the treatment of the aforementioned diseases. It is important that even today this kind of perspective is feasible due to the synthesis of a series of GPR14 blockers. The objective of this review is to discuss current molecular mechanisms of biological activity, regulatory functions of UT II, its role in the pathogenesis of different nosologies, as well as analysis of the possible routes of exposure to GPR14 as potential therapeutic targets.
C1 [Svistunov, Andrey A.; Tarasov, Vadim V.; Shakhmardanova, Svetlana A.; Sologova, Susanna S.; Bagaturiya, Ekaterina T.; Chubarev, Vladimir N.] Sechenov First Moscow State Med Univ, Inst Pharm & Translat Med, Moscow 19991, Russia.
   [Galenko-Yaroshevsky, Pavel A.] Kuban State Med Univ, Krasnodar 350063, Russia.
   [Fidel Avila-Rodriguez, Marco] Univ Tolima, Fac Ciencias Salud, Dept Ciencias Clin, Ibague, Colombia.
   [Barreto, George E.] Pontificia Univ Javeriama, Dept Nutr & Bioquim, Fac Ciencias, Bogota, DC, Colombia.
   [Barreto, George E.] Univ Autonoma Chile, Inst Ciencias Biomed, Santiago, Chile.
   [Aliev, Gjumrakch] GALLY Int Biomed Res Consulting LLC, 7733 Louis Pasteur,Dr 330, San Antonio, TX 78229 USA.
   [Aliev, Gjumrakch] Univ Atlanta, Sch Hlth Sci & Healthcare Adm, E Johns Crossing 175, Johns Creek, GA 30097 USA.
   [Aliev, Gjumrakch] Russian Acad Sci, Inst Physiol Act Cpds, Chernogolovka 142432, Russia.
C3 Sechenov First Moscow State Medical University; Kuban State Medical
   University; Universidad del Tolima; Universidad Autonoma de Chile; Gally
   International Biomedical Research & Consulting LLC; Russian Academy of
   Sciences; Institute of Physiologically Active Compounds of the Russian
   Academy of Sciences
RP Aliev, G (corresponding author), GALLY Int Biomed Res Consulting LLC, 7733 Louis Pasteur,Dr 330, San Antonio, TX 78229 USA.
EM aliev03@gmail.com
RI Lebedeva, Svetlana/AAE-2610-2019; Sologova, Susanna/AHB-5896-2022;
   Aliev, Gjumrakch/AAE-7734-2020; Barreto, George E./LQJ-8882-2024;
   Chubarev, Vladimir/J-4321-2017; Galenko-Yaroshevsky, Pavel/O-8817-2017
OI Galenko-AROSEVSKII, Pavel/0000-0003-3190-1437; Chubarev,
   Vladimir/0000-0002-7047-1436; Galenko-Yaroshevsky,
   Pavel/0000-0003-0873-284X; Avila-Rodriguez, Marco/0000-0003-4612-3236;
   Aliev, Gjumrakch/0000-0001-7373-3182; Barreto, George
   E./0000-0002-6644-1971; Tarasov, Vadim Vladimirovic/0000-0002-9394-7994;
   Sologova, Susanna/0000-0002-8526-7147
FU GALLY International Biomedical Research Consulting LLC, San Antonio,
   Texas, USA
FX This work partially supported by GALLY International Biomedical Research
   Consulting LLC, San Antonio, Texas, USA. We are also very thankful to
   Ms. Galina Alieva for her editorial work throughout preparation of this
   manuscript.
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NR 130
TC 17
Z9 20
U1 0
U2 23
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1389-2037
EI 1875-5550
J9 CURR PROTEIN PEPT SC
JI Curr. Protein Pept. Sci.
PY 2018
VL 19
IS 9
BP 924
EP 934
DI 10.2174/1389203718666170829162335
PG 11
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA GN4AI
UT WOS:000438954300010
PM 28875851
DA 2025-06-11
ER

PT J
AU Kardum, N
   Takic, M
   Savikin, K
   Zec, M
   Zdunic, G
   Spasic, S
   Konic-Ristic, A
AF Kardum, Nevena
   Takic, Marija
   Savikin, Katarina
   Zec, Manja
   Zdunic, Gordana
   Spasic, Slavica
   Konic-Ristic, Aleksandra
TI Effects of polyphenol-rich chokeberry juice on cellular antioxidant
   enzymes and membrane lipid status in healthy women
SO JOURNAL OF FUNCTIONAL FOODS
LA English
DT Article
DE Chokeberry; Polyphenols; Membrane fatty acids status; Antioxidant
   enzymes; Cardiovascular health
ID FATTY-ACID-COMPOSITION; OXIDATIVE STRESS; ARONIA-MELANOCARPA;
   BLOOD-PRESSURE; DOCOSAHEXAENOIC ACID; ERYTHROCYTE-MEMBRANE; DIETARY
   POLYPHENOLS; METABOLIC SYNDROME; PEROXIDATION; EXTRACT
AB The effect of long-term polyphenol-rich chokeberry juice consumption on activities of antioxidant enzymes and membrane lipid status in erythrocytes of 25 healthy women was examined. Percentages of membrane fatty acids, superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities were assessed at a baseline, in the middle and at the end of a 3-month-long consumption period. A significant increase in C22:6n-3, n-3 polyunsaturated fatty acids (PUFAs), total PUFAs and unsaturation index and a significant decrease in monounsaturated fatty acids (MUFAs) and n-6:n-3 ratio were found. Significantly higher SOD and GP(x) activities were also recorded at the end of the study. Serum lipids and glucose were stabile during the consumption period, while the levels of thiobarbituric acid-reactive substances (TBARS), as serum indicator of lipid peroxidation, were reduced significantly. These results indicate a positive impact of regular chokeberry juice consumption on cellular oxidative damage and suggest its putative role in the protection against oxidative stress. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Kardum, Nevena; Takic, Marija; Zec, Manja; Konic-Ristic, Aleksandra] Univ Belgrade, Inst Med Res, Ctr Res Excellence Nutr & Metab, Belgrade 11000, Serbia.
   [Savikin, Katarina; Zdunic, Gordana] Inst Med Plants Res, Belgrade 11000, Serbia.
   [Spasic, Slavica] Univ Belgrade, Fac Pharm, Dept Med Biochem, Belgrade 11000, Serbia.
C3 University of Belgrade; University of Belgrade
RP Konic-Ristic, A (corresponding author), Univ Belgrade, Inst Med Res, Ctr Res Excellence Nutr & Metab, Dr Subotica 4, Belgrade 11000, Serbia.
EM sandrakonic@gmail.com
RI Konic Ristic, Aleksandra/KDM-9154-2024; Vidovic, Nevena/AFT-1529-2022;
   Konic Ristic, Aleksandra/D-7634-2014; Zec, Manja/T-5942-2019
OI Kardum Vidovic, Nevena/0000-0001-6931-3695; Konic Ristic,
   Aleksandra/0000-0002-1218-1190; Zec, Manja/0000-0001-5283-9295; Savikin,
   Katarina/0000-0002-2086-9593; Zdunic, Gordana/0000-0002-5793-3739
FU Ministry of Education and Science of Serbia [41030, 46013]
FX The authors acknowledge financial support from the Ministry of Education
   and Science of Serbia, project numbers 41030 and 46013. We are also
   grateful to Conimex trade d.o.o., Belgrade, Serbia.
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NR 57
TC 60
Z9 67
U1 1
U2 49
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1756-4646
EI 2214-9414
J9 J FUNCT FOODS
JI J. Funct. Food.
PD JUL
PY 2014
VL 9
BP 89
EP 97
DI 10.1016/j.jff.2014.04.019
PG 9
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA AK2TH
UT WOS:000338271900010
DA 2025-06-11
ER

PT J
AU Andriantsitohaina, R
   Auger, C
   Chataigneau, T
   Étienne-Selloum, N
   Li, HG
   Martínez, MC
   Schini-Kerth, VB
   Laher, I
AF Andriantsitohaina, Ramaroson
   Auger, Cyril
   Chataigneau, Thierry
   Etienne-Selloum, Nelly
   Li, Huige
   Martinez, M. Carmen
   Schini-Kerth, Valerie B.
   Laher, Ismail
TI Molecular mechanisms of the cardiovascular protective effects of
   polyphenols
SO BRITISH JOURNAL OF NUTRITION
LA English
DT Review
DE Polyphenols; Cardiovascular system; Nitric oxide; Endothelium; Free
   radicals; Antioxidants
ID RED WINE POLYPHENOLS; ACTIVATED PROTEIN-KINASE; NITRIC-OXIDE SYNTHASE;
   CONVERTING ENZYME-ACTIVITY; ENDOTHELIUM-DEPENDENT VASORELAXATION;
   ISCHEMIC BRAIN-DAMAGE; OXIDATIVE STRESS; ANGIOTENSIN-II;
   ESTROGEN-RECEPTOR; IN-VIVO
AB Epidemiological studies have reported a greater reduction in cardiovascular risk and metabolic disorders associated with diets rich in polyphenols. The antioxidant effects of polyphenols are attributed to the regulation of redox enzymes by reducing reactive oxygen species production from mitochondria, NADPH oxidases and uncoupled endothelial NO synthase in addition to also up-regulating multiple antioxidant enzymes. Although data supporting the effects of polyphenols in reducing oxidative stress are promising, several studies have suggested additional mechanisms in the health benefits of polyphenols. Polyphenols from red wine increase endothelial NO production leading to endothelium-dependent relaxation in conditions such as hypertension, stroke or the metabolic syndrome. Numerous molecules contained in fruits and vegetables can activate sirtuins to increase lifespan and silence metabolic and physiological disturbances associated with endothelial NO dysfunction. Although intracellular pathways involved in the endothelial effects of polyphenols are partially described, the molecular targets of these polyphenols are not completely elucidated. We review the novel aspects of polyphenols on several targets that could trigger the health benefits of polyphenols in conditions such as metabolic and cardiovascular disturbances.
C1 [Laher, Ismail] Univ British Columbia, Fac Med, Dept Pharmacol & Therapeut, Vancouver, BC V6T 1Z3, Canada.
   [Andriantsitohaina, Ramaroson; Martinez, M. Carmen] Univ Angers, INSERM, U1063, LUNAM, Angers, France.
   [Auger, Cyril; Chataigneau, Thierry; Etienne-Selloum, Nelly; Schini-Kerth, Valerie B.] Univ Strasbourg, Fac Pharm, UMR CNRS 7213, Lab Biophoton & Pharmacol, Illkirch Graffenstaden, France.
   [Li, Huige] Johannes Gutenberg Univ Mainz, Univ Med Ctr, Dept Pharmacol, D-55131 Mainz, Germany.
C3 University of British Columbia; Universite d'Angers; Institut National
   de la Sante et de la Recherche Medicale (Inserm); Universites de
   Strasbourg Etablissements Associes; Universite de Strasbourg; Centre
   National de la Recherche Scientifique (CNRS); CNRS - National Institute
   for Biology (INSB); Johannes Gutenberg University of Mainz
RP Laher, I (corresponding author), Univ British Columbia, Fac Med, Dept Pharmacol & Therapeut, 2176 Hlth Sci Mall, Vancouver, BC V6T 1Z3, Canada.
EM ilaher@exchange.ubc.ca
RI Martinez, Maria Carmen/LSJ-1622-2024; Auger, Cyril/N-4702-2016; Laher,
   Ismail/X-3323-2019; ANDRIANTSITOHAINA, Ramaroson/H-5286-2018; Li,
   Huige/M-2662-2013
OI Auger, Cyril/0000-0003-0695-3841; Li, Huige/0000-0003-3458-7391;
   andriantsitohaina, ramaroson/0000-0002-4770-3585; Laher,
   Ismail/0000-0002-3917-4417; Martinez, M Carmen/0000-0003-3897-7397
FU Deutsche Forschungsgemeinschaft, Bonn, Germany [LI-1042/1-1]; Institut
   National de la Sante et de la Recherche Medicale (INSERM); University of
   Angers, France; Centre National de la Recherche Scientifique (CNRS);
   University of Strasbourg; Canadian Society of Pharmacology and
   Therapeutics
FX This study was supported by the Deutsche Forschungsgemeinschaft, Bonn,
   Germany (grant no. LI-1042/1-1) to H. L., by the Institut National de la
   Sante et de la Recherche Medicale (INSERM) and University of Angers,
   France to R. A. and M. C. M., by the Centre National de la Recherche
   Scientifique (CNRS) and University of Strasbourg to V. B. S.-K. and the
   Canadian Society of Pharmacology and Therapeutics to I. L. All authors
   contributed equally to the review. None of the authors has a conflict of
   interest with the work described herein.
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NR 196
TC 153
Z9 166
U1 3
U2 129
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1145
EI 1475-2662
J9 BRIT J NUTR
JI Br. J. Nutr.
PD NOV 14
PY 2012
VL 108
IS 9
BP 1532
EP 1549
DI 10.1017/S0007114512003406
PG 18
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 041JT
UT WOS:000311398800002
PM 22935143
OA Green Submitted, Bronze
DA 2025-06-11
ER

PT J
AU Chen, XT
   Huang, JF
   Liang, JM
   Li, LX
   Deng, KX
AF Chen, Xiting
   Huang, Jinfa
   Liang, Jiemei
   Li, Lixin
   Deng, Kaixian
TI Association of Serum Triglyceride and Stress Urinary Incontinence in
   Women From the National Health and Nutrition Examination Survey: A
   Cross- Sectional Study
SO UROLOGY
LA English
DT Article
ID QUALITY-OF-LIFE; RISK-FACTORS; METABOLIC SYNDROME; TRACT SYMPTOMS;
   PREVALENCE; COMPONENTS
AB OBJECTIVE To investigate the relationship between serum triglyceride levels and stress urinary incontinence (SUI) in women from the National Health and Nutrition Examination Survey. METHODS Adults who participated in the National Health and Nutrition Examination Survey from 2005 to 2018 were included in the study. Univariate and multivariate logistic regressions were used to assess the relationship between serum triglyceride levels and the incidence and severity of SUI. RESULTS Approximately 7973 participants (mean, 49.9 years of age) were enrolled in the study. Of those, 3367 had SUI, and 4606 did not have SUI. An adjusted multivariate logistic regression analysis demonstrated a positive correlation between serum triglyceride levels and the incidence of SUI (ORs, 1.05; 95% CI, 1-1.11, P = .045). Besides, subgroup analyses indicated that the results were robust among women with different characteristics. Additionally, serum triglyceride levels were positively associated with the severity of SUI. CONCLUSION Serum triglyceride levels were closely related to the incidence and severity of SUI. Based on our findings, we suggest that serum triglycerides can be included as a risk indicator for screening high -risk groups of SUI. UROLOGY 174: 64-69, 2023. (c) 2022 Elsevier Inc.
C1 [Chen, Xiting; Huang, Jinfa; Liang, Jiemei; Li, Lixin; Deng, Kaixian] Southern Med Univ, Shunde Hosp, Peoples Hosp Shunde 1, Dept Gynecol, 1 Jiazi Rd, Foshan, Guangdong, Peoples R China.
C3 Southern Medical University - China
RP Deng, KX (corresponding author), Southern Med Univ, Shunde Hosp, Peoples Hosp Shunde 1, Dept Gynecol, 1 Jiazi Rd, Foshan, Guangdong, Peoples R China.
EM nsyfek@163.com
OI , Kaixian/0000-0001-6246-8037
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NR 25
TC 5
Z9 5
U1 0
U2 3
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0090-4295
EI 1527-9995
J9 UROLOGY
JI Urology
PD APR
PY 2023
VL 174
BP 64
EP 69
DI 10.1016/j.urology.2022.11.011
EA APR 2023
PG 6
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA E4HE4
UT WOS:000975161300001
PM 36450317
DA 2025-06-11
ER

PT J
AU Rojas, A
   García-Lozano, MR
   Gil-Gómez, A
   Romero-Gómez, M
   Ampuero, J
AF Rojas, Angela
   Rosario Garcia-Lozano, Maria
   Gil-Gomez, Antonio
   Romero-Gomez, Manuel
   Ampuero, Javier
TI Glutaminolysis-ammonia-urea Cycle Axis, Non-alcoholic Fatty Liver
   Disease Progression and Development of Novel Therapies
SO JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY
LA English
DT Review
DE Non-alcoholic fatty liver disease; Cirrhosis; Fibrosis; Glutaminolysis;
   Ammonia; Urea
ID ORNITHINE-L-ASPARTATE; PLACEBO-CONTROLLED TRIAL;
   HEPATOCELLULAR-CARCINOMA; OBETICHOLIC ACID; OXIDATIVE STRESS;
   GLUTAMINASE; STEATOHEPATITIS; PHENYLACETATE; PATHOGENESIS; EXPRESSION
AB The prevalence of non-alcoholic fatty liver disease (NAFLD) is increasing worldwide, reflecting the current epidemics of obesity, insulin resistance, type 2 diabetes mellitus, and metabolic syndrome. NAFLD is characterized by the accumulation of fat in the liver, and is known to be a cause of cirrhosis. Although many pathways have been proposed, the cause of NAFLD-linked fibrosis progression is still unclear, which posed challenges for the development of new therapies to prevent NASH-related cirrhosis and hepatocellular carcinoma. Cirrhosis is associated with activation of hepatic stellate cells (HSC) and accumulation of excess extracellular matrix proteins, and inhibiting the activation of HSCs would be expected to slow the progression of NAFLD-cirrhosis. Multiple molecular signals and pathways such as oxidative stress and glutaminolysis have been reported to promote HSC activation. Both mechanisms are plausible antifibrotic targets in NASH, as the activation of HSCs the proliferation of myofibroblasts depend on those processes. This review summarizes the role of the glutaminolysis-ammonia-urea cycle axis in the context of NAFLD progression, and shows how the axis could be a novel therapeutic target.
C1 [Rojas, Angela; Rosario Garcia-Lozano, Maria; Gil-Gomez, Antonio; Romero-Gomez, Manuel; Ampuero, Javier] Virgen del Rocio Univ Hosp, Dept Unit Digest Dis, Seville, Spain.
   [Rojas, Angela; Rosario Garcia-Lozano, Maria; Gil-Gomez, Antonio; Romero-Gomez, Manuel; Ampuero, Javier] Univ Seville, Virgen del Rocio Univ Hosp, SeLiver Grp, Inst Biomed Seville IBIS,CSIC, Seville, Spain.
   [Rojas, Angela; Rosario Garcia-Lozano, Maria; Gil-Gomez, Antonio; Romero-Gomez, Manuel; Ampuero, Javier] Carlos III Natl Inst Hlth, Ctr Study Liver & Gastrointestinal Dis CIBERehd, Madrid, Spain.
   [Rosario Garcia-Lozano, Maria] Univ Seville, Fac Pharm, Dept Organ & Med Chem, E-41071 Seville, Spain.
C3 Virgen del Rocio University Hospital; Consejo Superior de
   Investigaciones Cientificas (CSIC); University of Sevilla; CSIC-JA-USE -
   Instituto de Biomedicina de Sevilla (IBIS); Virgen del Rocio University
   Hospital; CIBER - Centro de Investigacion Biomedica en Red; CIBERDEM;
   CIBEREHD; University of Sevilla
RP Ampuero, J (corresponding author), Virgen del Rocio Univ Hosp, Digest Dis Dept, Ave Manuel Siurot S-N, Seville 41013, Spain.; Ampuero, J (corresponding author), Virgen del Rocio Univ Hosp, CIBERehd, Ave Manuel Siurot S-N, Seville 41013, Spain.
EM jampuero-ibis@us.es
RI Gil-Gomez, Antonio/ABB-7349-2021; Rojas, Ana/D-5777-2011; DEL ROSARIO
   GARCIA-LOZANO, MARIA/AAM-9864-2021; Ampuero, Javier/AAI-2582-2019;
   Romero-Gomez, Manuel/L-8030-2014
OI Romero-Gomez, Manuel/0000-0001-8494-8947; GARCIA-LOZANO, MARIA DEL
   ROSARIO/0000-0002-6255-4960; Gil-Gomez, Antonio/0000-0001-9622-1761;
   Rojas, Angela/0000-0003-0853-4800; Ampuero, Javier/0000-0002-8332-2122
FU Spanish Ministry of Economy, Innovation and Competition, Instituto de
   Salud Carlos III [PI19/00589, PI19/01404, PI16/01842, PI17/00535,
   GLD19/00100]; Instituto de Salud Carlos III [CD18/00126]
FX This project was funded in part by the Spanish Ministry of Economy,
   Innovation and Competition, Instituto de Salud Carlos III (PI19/00589,
   PI19/01404, PI16/01842, PI17/00535 and GLD19/00100). Angela Rojas has
   received the Sara Borrell postdoctoral fellowships from Instituto de
   Salud Carlos III CD18/00126 to support her postdoctoral contract. The
   funders did not have any role in this review.
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NR 65
TC 11
Z9 11
U1 0
U2 23
PU XIA & HE PUBLISHING INC
PI SUGAR LAND
PA SECOND AFFILIATED HOSP CHONGQING MEDICAL UNIV, 14090 SOUTHWEST FREEWAY,
   STE 300, SUGAR LAND, TX 77478 USA
SN 2225-0719
EI 2310-8819
J9 J CLIN TRANSL HEPATO
JI J. Clin. Transl. Hepatol.
PD MAR-APR
PY 2022
VL 10
IS 2
BP 356
EP 362
DI 10.14218/JCTH.2021.00247
PG 7
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 1F2OL
UT WOS:000795012200020
PM 35528989
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Zhong, HX
   Dong, JY
   Zhu, LY
   Mao, JX
   Dong, JF
   Zhao, YY
   Zou, Y
   Guo, M
   Ding, GS
AF Zhong, Hanxiang
   Dong, Jiayong
   Zhu, Liye
   Mao, Jiaxi
   Dong, Junfeng
   Zhao, Yuanyu
   Zou, You
   Guo, Meng
   Ding, Guoshan
TI Non-alcoholic fatty liver disease: pathogenesis and models
SO AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
LA English
DT Review
DE non-alcoholic fatty liver disease (NAFLD); non-alcoholic steatohepatitis
   (NASH); histopathology; pathogenesis; treatment; animal models
ID ENDOPLASMIC-RETICULUM STRESS; DIET-INDUCED NASH; INSULIN-RESISTANCE;
   FRUCTOSE CONSUMPTION; ANIMAL-MODELS; STEATOHEPATITIS; FIBROSIS;
   ADIPONECTIN; MICE; ACTIVATION
AB Non-alcoholic fatty liver disease (NAFLD) is a complex disease characterized by a massive accumulation of lipids in the liver, with a continuous progression of simple steatosis, non-alcoholic steatohepatitis (NASH), cirrhosis, and hepatocellular carcinoma. Non-alcoholic fatty liver disease is associated with obesity, insulin resistance, and metabolic syndrome; it is a severe public health risk and is currently the most common liver disease of the world. In addition to the fatty infiltration of the liver in non-alcoholic fatty liver disease patients, the field of liver transplantation faces similar obstacles. NAFLD and NASH primarily involve lipotoxicity, inflammation, oxidative stress, and insulin resistance. However, the precise mechanisms and treatments remain unclear. Therapeutic approaches encompass exercise, weight control, as well as treatments targeting antioxidants and anti-inflammatory pathways. The role of animal models in research has become crucial as a key tool to explore the molecular mechanisms and potential treatments for non-alcoholic fatty liver disease and non-alcoholic steatohepatitis. Here, we summarized the current understanding of the pathogenesis of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis and discussed animal models commonly used in recent years.
C1 [Zhong, Hanxiang; Dong, Jiayong; Mao, Jiaxi; Dong, Junfeng; Zhao, Yuanyu; Zou, You; Guo, Meng; Ding, Guoshan] Navy Med Univ, Changzheng Hosp, Dept Liver Surg & Organ Transplantat, Shanghai, Peoples R China.
   [Zhu, Liye; Guo, Meng] Navy Med Univ, Natl Key Lab Immun & Inflammat, Shanghai, Peoples R China.
   [Zhu, Liye; Guo, Meng] Navy Med Univ, Inst Immunol, Shanghai, Peoples R China.
C3 Naval Medical University; Naval Medical University; Naval Medical
   University
RP Zou, Y; Guo, M; Ding, GS (corresponding author), Navy Med Univ, Changzheng Hosp, Dept Liver Surg & Organ Transplantat, Shanghai, Peoples R China.
EM ayou1616@sina.com; guo918meng@163.com; dingguoshanmail@163.com
RI Mao, Jia-Xi/IAR-5310-2023; dong, junfeng/GZL-6072-2022; Zhu,
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NR 72
TC 12
Z9 12
U1 10
U2 28
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 1943-8141
J9 AM J TRANSL RES
JI Am. J. Transl. Res.
PY 2024
VL 16
IS 2
BP 387
EP 399
PG 13
WC Oncology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Research & Experimental Medicine
GA KI2T9
UT WOS:001179273000002
PM 38463579
DA 2025-06-11
ER

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   Gancarz, Marek
   Wojtunik-Kulesza, Karolina
   Markut-Miotla, Ewa
   Oniszczuk, Anna
TI The Efficacy of Black Chokeberry Fruits against Cardiovascular Diseases
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE Aronia melanocarpa L; black chokeberry; polyphenols; metabolic syndrome;
   metabolic diseases; type 2 diabetes; obesity; cardiovascular diseases
ID POLYPHENOL-RICH EXTRACT; ARONIA-MELANOCARPA; BLOOD-PRESSURE; IN-VITRO;
   ANTIOXIDANT CAPACITY; PHENOLIC-COMPOUNDS; OXIDATIVE STRESS; ANTIRADICAL
   ACTIVITY; JUICE CONSUMPTION; ANTHOCYANINS
AB Epidemiological studies have emphasized the association between a diet rich in fruits and vegetables and a lower frequency of occurrence of inflammatory-related disorders. Black chokeberry (Aronia melanocarpa L.) is a valuable source of biologically active compounds that have been widely investigated for their role in health promotion and cardiovascular disease prevention. Many in vitro and in vivo studies have demonstrated that consumption of these fruits is associated with significant improvements in hypertension, LDL oxidation, lipid peroxidation, total plasma antioxidant capacity and dyslipidemia. The mechanisms for these beneficial effects include upregulation of endothelial nitric oxide synthase, decreased oxidative stress, and inhibition of inflammatory gene expression. Collected findings support the recommendation of such berries as an essential fruit group in a heart-healthy diet. The aim of this review was to summarize the reports on the impact of black chokeberry fruits and extracts against several cardiovascular diseases, e.g., hyperlipidemia, hypercholesterolemia, hypertension, as well as to provide an analysis of the antioxidant and anti-inflammatory effect of these fruits in the abovementioned disorders.
C1 [Kasprzak-Drozd, Kamila; Wojtunik-Kulesza, Karolina; Oniszczuk, Anna] Med Univ Lublin, Dept Inorgan Chem, Chodzki 4a, PL-20093 Lublin, Poland.
   [Oniszczuk, Tomasz; Soja, Jakub] Univ Life Sci Lublin, Dept Thermal Technol & Food Proc Engn, Gleboka 31, PL-20612 Lublin, Poland.
   [Gancarz, Marek] Polish Acad Sci, Inst Agrophys, Doswiadczalna 4, PL-20290 Lublin, Poland.
   [Markut-Miotla, Ewa] Med Univ Lublin, Dept Lung Dis & Rheumatol, PL-20093 Lublin, Poland.
C3 Medical University of Lublin; University of Life Sciences in Lublin;
   Polish Academy of Sciences; Bohdan Dobrzanski Institute of Agrophysics
   of the Polish Academy of Sciences; Medical University of Lublin
RP Oniszczuk, A (corresponding author), Med Univ Lublin, Dept Inorgan Chem, Chodzki 4a, PL-20093 Lublin, Poland.; Oniszczuk, T (corresponding author), Univ Life Sci Lublin, Dept Thermal Technol & Food Proc Engn, Gleboka 31, PL-20612 Lublin, Poland.
EM kamilakasprzakdrozd@gmail.com; tomasz.oniszczuk@up.lublin.pl;
   jakubsoja97@wp.pl; m.gancarz@ipan.lublin.pl; karolina.wojtonik@umlub.pl;
   ewa.markut-miotla@umlub.pl; anoniszczuk@o2.pl
RI Gancarz, Marek/AAF-5498-2019; Oniszczuk, Anna/A-2397-2019; Oniszczuk,
   Tomasz/Z-1941-2018
OI Kasprzak-Drozd, Kamila/0000-0002-6282-6313; Oniszczuk,
   Anna/0000-0002-5109-3302; Soja, Jakub/0000-0001-5232-083X; Oniszczuk,
   Tomasz/0000-0002-1061-6541; Gancarz, Marek/0000-0003-4719-2954
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NR 110
TC 37
Z9 38
U1 1
U2 45
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD JUN
PY 2021
VL 22
IS 12
AR 6541
DI 10.3390/ijms22126541
PG 19
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA SY8YF
UT WOS:000666165900001
PM 34207143
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Garcia-Flores, LA
   Medina, S
   Cejuela-Anta, R
   Martinez-Sanz, JM
   Abellan, A
   Genieser, HG
   Ferreres, F
   Gil-Izquierdo, A
AF Alejandra Garcia-Flores, Libia
   Medina, Sonia
   Cejuela-Anta, Roberto
   Miguel Martinez-Sanz, Jose
   Abellan, Angel
   Genieser, Hans-Gottfried
   Ferreres, Federico
   Gil-Izquierdo, Angel
TI DNA catabolites in triathletes: effects of supplementation with an
   aronia-citrus juice (polyphenols-rich juice)
SO FOOD & FUNCTION
LA English
DT Article
ID OXIDATIVE STRESS; METABOLIC SYNDROME; PHYSICAL-EXERCISE; DAMAGE;
   PEROXYNITRITE; BIOMARKERS; 8-NITROGUANOSINE; GENERATION; INCREASES;
   PRODUCT
AB In this study we analyzed whether our aronia-citrus juice (ACJ, the composition is based on a mixture of 95% citrus juice with 5% of Aronia melanocarpa juice), rich in polyphenols, and physical exercise had an effect on seven catabolites of DNA identified in plasma and on a urine isoprostane (8-iso-PGF(2 alpha)). Sixteen elite triathletes on a controlled diet for triathlon training (45 days) were used in this clinical trial. Our results show a decrease in the 8-hydroxy-2'-deoxyguanosine concentration due to chronic physical exercise. The ACJ intake and physical exercise maintained the guanosine-3', 5'-cyclic monophosphate plasmatic concentrations and decreased the concentration of 8-hydroxyguanine as well as urinary values of 8-iso-PGF(2 alpha). Finally, we observed a significant increase in the 8-nitroguanosine levels in triathletes after ACJ intake, compared to the placebo stage. It is concluded that the combination of the intake of ACJ, rich in polyphenolic compounds, with adequate training was able to influence the plasmatic and urinary values of oxidative stress biomarkers. This suggests a positive effect on the oxidative damage and potential associations with DNA repair mechanisms.
C1 [Alejandra Garcia-Flores, Libia; Medina, Sonia; Abellan, Angel; Ferreres, Federico; Gil-Izquierdo, Angel] CEBAS CSIC, Dept Food Sci & Technol, Campus Espinardo 25, Murcia 30100, Spain.
   [Cejuela-Anta, Roberto; Miguel Martinez-Sanz, Jose] Univ Alicante, Fac Educ, Dept Phys Educ & Sport, Campus San Vicente del Raspeig, Alicante 03540, Spain.
   [Genieser, Hans-Gottfried] CBIOLOG Life Sci Inst, Flughafendamm 9a, D-28199 Bremen, Germany.
C3 Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Centro de
   Edafologia y Biologia Aplicada del Segura (CEBAS); Universitat d'Alacant
RP Gil-Izquierdo, A (corresponding author), CEBAS CSIC, Dept Food Sci & Technol, Campus Espinardo 25, Murcia 30100, Spain.
EM angelgil@cebas.csic.es
RI Ferreres, Federico/JCO-4553-2023; Cejuela, Roberto/AAE-7727-2022;
   Abellán Guillén, Adela/O-9514-2016; SANZ, JOSE/M-1255-2019; Garcia
   Flores, Libia Alejandra/GPF-8059-2022; Martinez Sanz, Jose
   Miguel/F-4892-2017; Medina, Sonia/M-2479-2014; Gil-Izquierdo,
   Angel/B-5563-2008
OI Genieser, Hans-Gottfried/0000-0002-4904-5790; Martinez Sanz, Jose
   Miguel/0000-0001-9054-3858; Medina, Sonia/0000-0002-7231-6480;
   Gil-Izquierdo, Angel/0000-0001-7646-0386; Garcia Flores, Libia
   Alejandra/0000-0001-8299-5256
FU Spanish government [BES2012-060185]; (CICYT) (Spanish Ministry of
   Economy and Competitiveness) [AGL2011-23690]; "Fundacion Seneca de la
   Region de Murcia" Grupo de Excelencia [19900/GERM/15]
FX LAGF was awarded a pre-doctoral FPI fellowship (BES2012-060185) by the
   Spanish government. The authors are also grateful to the University of
   Alicante for its collaboration. We are grateful to Dr David Walker
   (native English speaker) for his reviews of the English grammar and
   style of the current report. This study was supported by the project
   AGL2011-23690 (CICYT) (Spanish Ministry of Economy and Competitiveness).
   This work has been partially funded by the "Fundacion Seneca de la
   Region de Murcia" Grupo de Excelencia 19900/GERM/15. The authors declare
   that they have no conflict of interest.
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NR 55
TC 13
Z9 13
U1 0
U2 10
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PY 2016
VL 7
IS 4
BP 2084
EP 2093
DI 10.1039/c6fo00252h
PG 10
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA DK3BM
UT WOS:000374790000041
PM 27050256
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Matsuzawa-Nagata, N
   Takamura, T
   Ando, H
   Nakamura, S
   Kurita, S
   Misu, H
   Ota, T
   Yokoyama, M
   Honda, M
   Miyamoto, KI
   Kaneko, S
AF Matsuzawa-Nagata, Naoto
   Takamura, Toshinari
   Ando, Hitoshi
   Nakamura, Seiji
   Kurita, Seiichiro
   Misu, Hirofumi
   Ota, Tsuguhito
   Yokoyama, Masayoshi
   Honda, Masao
   Miyamoto, Ken-ichi
   Kaneko, Shuichi
TI Increased oxidative stress precedes the onset of high-fat diet-induced
   insulin resistance and obesity
SO METABOLISM-CLINICAL AND EXPERIMENTAL
LA English
DT Article
ID ENERGY-EXPENDITURE; ACID OXIDATION; EXPRESSION; LIVER; HYPERGLYCEMIA;
   ACTIVATION; TRANSPORT; PATHWAY; KINASE; ALPHA
AB insulin resistance is a key pathophysiological feature of metabolic syndrome. However, the initial events triggering the development of insulin resistance and its causal relations with dysregulation of glucose and fatty acids metabolism remain unclear. We investigated biological pathways that have the potential to induce insulin resistance in mice fed a high-fat diet (HFD). We demonstrate that the pathways for reactive oxygen species (ROS) production and oxidative stress are coordinately up-regulated in both the liver and adipose tissue of mice fed an HFD before the onset of insulin resistance through discrete mechanism. In the liver, an HFD up-regulated genes involved in sterol regulatory element binding protein 1c-related fatty acid synthesis and peroxisome proliferator-activated receptor a-related fatty acid oxidation. In the adipose tissue, however, the HFD down-regulated genes involved in fatty acid synthesis and up-regulated nicotinamide adenine dinucleotide phosphate (NADPH) oxidase complex. Furthermore, increased ROS production preceded the elevation of tumor necrosis factor-a and free fatty acids in the plasma and liver. The ROS may be an initial key event triggering HFD-induced insulin resistance. (C) 2008 Elsevier Inc. All rights reserved.
C1 [Matsuzawa-Nagata, Naoto; Takamura, Toshinari; Ando, Hitoshi; Nakamura, Seiji; Kurita, Seiichiro; Misu, Hirofumi; Ota, Tsuguhito; Yokoyama, Masayoshi; Honda, Masao; Kaneko, Shuichi] Kanazawa Univ, Grad Sch Med Sci, Dept Dis Control & Homeostasis, Kanazawa, Ishikawa 9208641, Japan.
   [Matsuzawa-Nagata, Naoto; Nakamura, Seiji; Miyamoto, Ken-ichi] Kanazawa Univ, Grad Sch Med Sci, Dept Med Informat, Kanazawa, Ishikawa 9208641, Japan.
C3 Kanazawa University; Kanazawa University
RP Takamura, T (corresponding author), Kanazawa Univ, Grad Sch Med Sci, Dept Dis Control & Homeostasis, Kanazawa, Ishikawa 9208641, Japan.
EM ttakamura@m-kanazawa.jp
RI ANDO, Hitoshi/O-8199-2016; Nagata, Naoto/D-9261-2012
OI Nagata, Naoto/0000-0002-2389-2334
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NR 23
TC 421
Z9 491
U1 2
U2 28
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0026-0495
J9 METABOLISM
JI Metab.-Clin. Exp.
PD AUG
PY 2008
VL 57
IS 8
BP 1071
EP 1077
DI 10.1016/j.metabol.2008.03.010
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 334BC
UT WOS:000258196300009
PM 18640384
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Hurjui, RM
   Hurjui, IA
   Pinzariu, GM
   Cojocaru, T
   Neamtu, A
AF Hurjui, Ruxandra Maria
   Hurjui, Ion Andrei
   Pinzariu, Giulia Mihaela
   Cojocaru, Tudor
   Neamtu, Andrei
TI DIET IMPACT ON ORAL HEALTH AND ENDOTHELIAL FUNCTION
SO ROMANIAN JOURNAL OF ORAL REHABILITATION
LA English
DT Article
DE diet; oral health; endothelial function
ID MULTIDISCIPLINARY TEAM-APPROACH; TERM CALORIE RESTRICTION; OXIDATIVE
   STRESS; DEPENDENT VASODILATION; MEDITERRANEAN DIET; LOW-CARBOHYDRATE;
   NITRIC-OXIDE; FAT DIET; DISEASE; DYSFUNCTION
AB Since many years ago a lot of studies conclude that the components of the human body are closely interdependent; as a result, disease conditions in some organs or components can influence the development of disease in other body locations. The effect of oral health upon health in general has been investigated for decades by many epidemiological studies. That is why, there appears to be a clear relationship between deficient oral health and different systemic disorders such as cardiovascular disease and metabolic syndrome. The precise relationship between them is the subject of ongoing research, and a variety of theories have been proposed, though most of them postulate the mediation of an inflammatory response. This association between the oral cavity diet and endothelial function in general requires further study, and health professionals should mark the importance of adopting measures destined to promote correct oral health.
C1 [Hurjui, Ruxandra Maria; Hurjui, Ion Andrei; Pinzariu, Giulia Mihaela; Cojocaru, Tudor; Neamtu, Andrei] Grigore T Popa Univ Med & Pharm Iasi, Fac Med, Iasi, Romania.
C3 Grigore T Popa University of Medicine & Pharmacy
RP Hurjui, IA (corresponding author), Grigore T Popa Univ Med & Pharm Iasi, Fac Med, Iasi, Romania.
EM hurjuiion@yahoo.com
RI Neamtu, Andrei/MTF-8443-2025
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PU ROMANIAN SOC ORAL REHABILITATION ASSOC
PI IASI
PA KOGALNICEANU ST, NR 2, IASI, 00000, ROMANIA
EI 2066-7000
J9 ROM J ORAL REHABIL
JI Rom. J. Oral Rehabil.
PD JUL-AUG
PY 2022
VL 14
IS 3
BP 67
EP 77
PG 11
WC Dentistry, Oral Surgery & Medicine
WE Emerging Sources Citation Index (ESCI)
SC Dentistry, Oral Surgery & Medicine
GA 5W5IZ
UT WOS:000877948700008
DA 2025-06-11
ER

PT J
AU Radak, D
   Resanovic, I
   Isenovic, ER
AF Radak, Djordje
   Resanovic, Ivana
   Isenovic, Esma R.
TI Changes in Hypothalamus-Pituitary-Adrenal Axis Following Transient
   Ischemic Attack
SO ANGIOLOGY
LA English
DT Article
DE hypothalamic-pituitary-adrenal axis; acute brain ischemia; transient
   ischemic attack; stroke
ID BRAIN NATRIURETIC PEPTIDE; CORTICOTROPIN-RELEASING-FACTOR;
   CEREBRAL-ARTERY OCCLUSION; ARGININE-VASOPRESSIN V-1; INTERNAL
   CAROTID-ARTERY; METABOLIC SYNDROME; ACTH RELEASE; ADRENOCORTICAL AXIS;
   LIMBIC SYSTEM; HEART-DISEASE
AB Acute brain ischemia caused by transient ischemic attack initiates a complex sequence of events in the central nervous system and hypothalamic-pituitary-adrenal (HPA) axis which may ultimately culminate in neuronal and cell damage. The brain is highly susceptible to ischemia and in response to stress shows changes in morphology and chemistry that are largely reversible. These responses are known to modify the function of the HPA axis, but their mechanisms are not yet clear. Duration and size of the HPA axis activation are regulated by corticotropin-releasing hormone, vasopressin (AVP), and glucocorticoids, including cortisol. Numerous studies suggest that activation of these hormones following brain ischemia can result in neurohormonal dysfunction that can exacerbate long-term prognosis following stroke. These studies represent evidence that changes in the HPA axis play an important role in brain ischemia.
C1 [Radak, Djordje] Univ Belgrade, Dept Vasc Surg, Dedinje Cardiovasc Inst, Fac Med, Belgrade 11000, Serbia.
   [Resanovic, Ivana; Isenovic, Esma R.] Univ Belgrade, Lab Radiobiol & Mol Genet, Inst Vinca, Belgrade 11000, Serbia.
C3 University of Belgrade; University of Belgrade
RP Isenovic, ER (corresponding author), Univ Belgrade, Lab Radiobiol & Mol Genet, Inst Vinca, POB 522, Belgrade 11000, Serbia.
EM isenovic@yahoo.com
RI Isenovic, Esma/D-3017-2009
OI Isenovic, Esma/0000-0002-0012-2636; Resanovic, Ivana/0000-0003-2742-7912
FU Ministry of Education and Science, Republic of Serbia [41002, 173033]
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: This work
   was supported by grants funded by the Ministry of Education and Science,
   Republic of Serbia, No. 41002 (to Dj.R.) and No. 173033 (to E.R.I.).
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NR 135
TC 31
Z9 35
U1 2
U2 22
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0003-3197
EI 1940-1574
J9 ANGIOLOGY
JI Angiology
PD SEP
PY 2014
VL 65
IS 8
BP 723
EP 732
DI 10.1177/0003319713503487
PG 10
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA AN6OX
UT WOS:000340715700011
PM 24065626
DA 2025-06-11
ER

PT J
AU Da Silva, MS
   Rudkowska, I
AF Da Silva, Marine S.
   Rudkowska, Iwona
TI Dairy products on metabolic health: Current research and clinical
   implications
SO MATURITAS
LA English
DT Review
DE Dairy products; Obesity; Dyslipidemia; Hyperglycemia; Hypertension;
   Inflammation
ID ENERGY-RESTRICTED DIET; WEIGHT-LOSS; BODY-COMPOSITION; LOW-FAT;
   INSULIN-RESISTANCE; CARDIOVASCULAR-DISEASE; INFLAMMATORY STRESS;
   BLOOD-PRESSURE; CONSUMPTION; OVERWEIGHT
AB Dairy products have been thought to have a beneficial role in the metabolic syndrome (MetS). MetS constitutes a cluster of risk factors for an increased mortality, including obesity, impaired glucose homeostasis, hypertension and atherogenic dyslipidemia. Individuals with MetS are also often in a chronic, low-grade inflammatory state. The objective of this review is to examine recent meta-analyses and clinical studies on the association between dairy products consumption and these MetS risk factors. Findings from studies demonstrate that weight loss related to dairy product intake is due to the combination of an energy-restricted diet with consumption of dairy products. Further, a limited number of studies have shown beneficial effects of dairy consumption on plasma lipids, blood pressure, glucose homeostasis or inflammatory and oxidative stress profiles. Overall, this review article suggests that adults should consume at least 2-3 servings of dairy products per day within a well-balanced diet and a healthy lifestyle for metabolic health. Yet, higher dairy product consumption may have additional beneficial effects, but more well-designed intervention studies are needed to ascertain these effects. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
C1 [Da Silva, Marine S.; Rudkowska, Iwona] CHU Quebec Res Ctr, Quebec City, PQ, Canada.
RP Rudkowska, I (corresponding author), CHU Quebec Res Ctr CHUL, T-4-55B,2705,Boul Laurier, Quebec City, PQ G1V 4G2, Canada.
EM iwona.rudkowska@crchul.ulaval.ca
OI Rudkowska, Iwona/0000-0003-2392-564X
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NR 53
TC 27
Z9 31
U1 0
U2 26
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0378-5122
EI 1873-4111
J9 MATURITAS
JI Maturitas
PD MAR
PY 2014
VL 77
IS 3
BP 221
EP 228
DI 10.1016/j.maturitas.2013.12.007
PG 8
WC Geriatrics & Gerontology; Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology; Obstetrics & Gynecology
GA AD8HP
UT WOS:000333507400005
PM 24445013
DA 2025-06-11
ER

PT J
AU Shiyan, S
   Suryani, RP
   Mulyani, LN
   Pratiwi, G
AF Shiyan, Shaum
   Suryani, Rizki Puji
   Mulyani, Laida Neti
   Pratiwi, Galih
TI Stability Study of Super Saturable Catechin-Self Nano Emulsifying Drug
   Delivery System as Antidiabetic Therapy
SO BIOINTERFACE RESEARCH IN APPLIED CHEMISTRY
LA English
DT Article
DE catechin; self-nano emulsifying; stability study; heating-cooling;
   freeze-thaw; FTIR-ATR
AB Diabetes mellitus is a metabolic syndrome characterized by hyperglycemic and increased ROS production, which causes oxidative stress. Catechin isolated from the tea plant has oxidative stress inhibitor activity and anti-diabetic activity with low absorption in circulation systemic. Therefore, it is formulated in a super saturable catechin-self nano emulsifying drug delivery system (SSC-SNEDDS). Stability is one of the factors that affect the safety, quality, and efficacy of SSC-SNEDDS. This study aims to evaluate the stability of the formulated oil phase using oleic acid, croduret as a surfactant, and propylene glycol as a co-surfactant. Stability studies were carried out by several tests, namely heating - cooling cycle assay, freeze-thaw cycle assay, centrifugation, and endurance assay. Droplet characterization in the form of changes in diameter, zeta potential, and mobility in evaluating stability tests using dynamic light scattering-particle size analyzer (DLS-PSA). Real-time stability was also evaluated by observing changes in the infrared spectrum pattern using FTIR-ATR. After the stability test, the emulsion droplet size of SSC-SNEDDS was still below 100 nm and showed good stability. It can be concluded that the formula has a good stability profile.
C1 [Shiyan, Shaum; Mulyani, Laida Neti] Univ Sriwijaya, Fac Math & Nat Sci, Dept Pharm, Indralaya OI, Sumatera Selatan 30662, Indonesia.
   [Shiyan, Shaum] Univ Sriwijaya, Fac Math & Nat Sci, Phytopharmaceut Res Ctr, Dept Pharm, Indralaya OI, Sumatera Selatan 30662, Indonesia.
   [Suryani, Rizki Puji] Univ Sriwijaya, Fac Med, Indralaya OI, Sumatera Selatan 30662, Indonesia.
   [Pratiwi, Galih] STIKES Aisyiyah Palembang, Dept Pharm, Sumatera Selatan 30152, Indonesia.
   [Pratiwi, Galih] STIKES Aisyiyah Palembang, Biomat & Drug Delivery Syst BiDDS Res Grp, Sumatera Selatan 30152, Indonesia.
C3 Universitas Sriwijaya; Universitas Sriwijaya; Universitas Sriwijaya
RP Shiyan, S (corresponding author), Univ Sriwijaya, Fac Math & Nat Sci, Dept Pharm, Indralaya OI, Sumatera Selatan 30662, Indonesia.; Shiyan, S (corresponding author), Univ Sriwijaya, Fac Math & Nat Sci, Phytopharmaceut Res Ctr, Dept Pharm, Indralaya OI, Sumatera Selatan 30662, Indonesia.
EM shaumshiyan@unsri.ac.id; galihpratiwi@stikesaisyiyah-palembang.ac.id
RI Shiyan, Shaum/AAD-7023-2022; Pratiwi, Galih/AAD-7550-2022
OI Suryani, Puji Rizki/0000-0001-9850-3519
FU Sains Teknologi dan Seni (SATEKS) Grand, Universitas Sriwijaya; DIPA
   Badan Layanan Umum Univeristas Sriwijaya [SP DIPA-023.17.2.677515/2021,
   0007/UN9/SK.LP2M.PT/2021]
FX This study was supported by Sains Teknologi dan Seni (SATEKS) Grand,
   Universitas Sriwijaya, DIPA Badan Layanan Umum Univeristas Sriwijaya
   with contract number SP DIPA-023.17.2.677515/2021 in accordance with
   Rector's Decree No. 0007/UN9/SK.LP2M.PT/2021.
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NR 25
TC 6
Z9 6
U1 0
U2 9
PU BIOINTERFACE RESEARCH APPLIED CHEMISTRY
PI BUCURESTI
PA BIOINTERFACE RESEARCH APPLIED CHEMISTRY, BUCURESTI, 00000, ROMANIA
SN 2069-5837
J9 BIOINTERFACE RES APP
JI Biointerface Res. Appl. Chem.
PD OCT 15
PY 2022
VL 12
IS 5
BP 5811
EP 5820
DI 10.33263/BRIAC125.58115820
PG 10
WC Chemistry, Applied
WE Emerging Sources Citation Index (ESCI)
SC Chemistry
GA YJ1CZ
UT WOS:000744276800006
OA gold
DA 2025-06-11
ER

PT J
AU Buyco, DG
   Martin, J
   Jeon, S
   Hooks, R
   Lin, C
   Carr, R
AF Buyco, Delfin Gerard
   Martin, Jasmin
   Jeon, Sookyoung
   Hooks, Royce
   Lin, Chelsea
   Carr, Rotonya
TI Experimental models of metabolic and alcoholic fatty liver disease
SO WORLD JOURNAL OF GASTROENTEROLOGY
LA English
DT Review
DE Non-alcoholic fatty liver disease; Alcoholic liver disease;
   Non-alcoholic steatohepatitis; Animal models; Insulin resistance;
   Oxidative stress
ID UNFOLDED PROTEIN RESPONSE; INTRAGASTRIC INFUSION; INSULIN-RESISTANCE;
   LIPID-METABOLISM; ANIMAL-MODELS; RISK-FACTORS; MOUSE MODEL; ETHANOL;
   CONSUMPTION; STEATOHEPATITIS
AB Non-alcoholic fatty liver disease (NAFLD) is a multi-systemic disease that is considered the hepatic manifestation of metabolic syndrome (MetS). Because alcohol consumption in NAFLD patients is common, there is a significant overlap in the pathogenesis of NAFLD and alcoholic liver disease (ALD). Indeed, MetS also significantly contributes to liver injury in ALD patients. This "syndrome of metabolic and alcoholic steatohepatitis" (SMASH) is thus expected to be a more prevalent presentation in liver patients, as the obesity epidemic continues. Several pre-clinical experimental models that couple alcohol consumption with NAFLD-inducing diet or genetic obesity have been developed to better understand the pathogenic mechanisms of SMASH. These models indicate that concomitant MetS and alcohol contribute to lipid dysregulation, oxidative stress, and the induction of innate immune response. There are significant limitations in the applicability of these models to human disease, such as the ability to induce advanced liver injury or replicate patterns in human food/alcohol consumption. Thus, there remains a need to develop models that accurately replicate patterns of obesogenic diet and alcohol consumption in SMASH patients.
C1 [Buyco, Delfin Gerard; Martin, Jasmin; Jeon, Sookyoung; Hooks, Royce; Lin, Chelsea; Carr, Rotonya] Univ Penn, Div Gastroenterol, 421 Curie Blvd 907 Biomed Res Ctr, Philadelphia, PA 19104 USA.
C3 University of Pennsylvania
RP Carr, R (corresponding author), Univ Penn, Div Gastroenterol, 421 Curie Blvd 907 Biomed Res Ctr, Philadelphia, PA 19104 USA.
EM rotonya.carr@pennmedicine.upenn.edu
RI Jeon, Sookyoung/AAL-8526-2021
OI Jeon, Sookyoung/0000-0002-3620-0851
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NR 123
TC 22
Z9 22
U1 3
U2 39
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 7041 Koll Center Parkway, Suite 160, PLEASANTON, CA, UNITED STATES
SN 1007-9327
EI 2219-2840
J9 WORLD J GASTROENTERO
JI World J. Gastroenterol.
PD JAN 7
PY 2021
VL 27
IS 1
BP 1
EP 18
DI 10.3748/wjg.v27.i1.1
PG 18
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA PU6NJ
UT WOS:000609418200001
PM 33505147
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Taye, A
   El-Sheikh, AAK
AF Taye, Ashraf
   El-Sheikh, Azza A. K.
TI Lectin-like oxidized low-density lipoprotein receptor 1 pathways
SO EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
LA English
DT Review
DE Apoptosis; inflammation; LOX-1; nitric oxide; oxidative stress; oxidized
   low-density lipoprotein
ID ENDOTHELIAL-CELLS; LDL RECEPTOR-1; LOX-1 EXPRESSION; NITRIC-OXIDE; RISK;
   GENE; INDUCTION; VARIANT; OBESITY; OLR1
AB Background The role of lectin-like oxidized low-density lipoprotein receptor (LOX)-1 has been implicated in the pathogenesis of different diseases, including atherosclerosis, hypertension, obesity, diabetes mellitus and metabolic syndrome. To date, several studies aimed at partially investigating the mechanistic role of LOX-1 in these various pathologies. Still, so far, the precise signal transduction pathways involving LOX-1 have not yet been elucidated. Materials and Methods The most recent data published by the authors as well as others concerning different pathways involving LOX-1 are collected to formulate the presented updated review. Results One of the most prominent pathways highlighted in the present review is the relationship of LOX-1 to NADPH oxidase that acts as a major source of harmful free radicals causing oxidative stress in blood vessels. Other pathways involve lipid and glucose metabolism-mediated signal transduction. Discussion The modulatory role of LOX-1 on nitric oxide and renin/angiotensin systems as well as on fibrosis, apoptosis and inflammatory pathways is discussed. Conclusion The current review revisits LOX-1 and its related pathways, implicating LOX-1 as a target for ameliorating various pathological conditions.
C1 [Taye, Ashraf] Menia Univ, Dept Pharmacol & Toxicol, Fac Med, Al Minya 61511, Egypt.
   [El-Sheikh, Azza A. K.] Menia Univ, Dept Pharmacol, Fac Med, Al Minya 61511, Egypt.
C3 Egyptian Knowledge Bank (EKB); Minia University; Egyptian Knowledge Bank
   (EKB); Minia University
RP El-Sheikh, AAK (corresponding author), Menia Univ, Dept Pharmacol, Fac Med, Al Minya 61511, Egypt.
EM azza.elsheikh@mu.edu.eg
RI El-Sheikh, Dr. Azza/K-2224-2013
OI El-Sheikh, Dr. Azza/0000-0003-3726-0386
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PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0014-2972
EI 1365-2362
J9 EUR J CLIN INVEST
JI Eur. J. Clin. Invest.
PD JUL
PY 2013
VL 43
IS 7
BP 740
EP 745
DI 10.1111/eci.12092
PG 6
WC Medicine, General & Internal; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Research & Experimental Medicine
GA 160NW
UT WOS:000320127400010
PM 23594336
DA 2025-06-11
ER

PT J
AU Montano, MAE
   Lera, JPB
   Gottlieb, MGV
   Schwanke, CHA
   da Rocha, MIUM
   Manica-Cattani, MF
   dos Santos, GF
   da Cruz, IBM
AF Echart Montano, Marco Aurelio
   Barrio Lera, Juan Pablo
   Valle Gottlieb, Maria Gabriela
   Augustin Schwanke, Carla Helena
   Ugalde Marques da Rocha, Maria Izabel
   Manica-Cattani, Maria Fernanda
   dos Santos, Greice Feyl
   Manica da Cruz, Ivana Beatrice
TI Association between manganese superoxide dismutase (MnSOD) gene
   polymorphism and elderly obesity
SO MOLECULAR AND CELLULAR BIOCHEMISTRY
LA English
DT Article
DE Obesity; Ala16val MnSOD polymorphism; Superoxide; Elderly;
   Nutrigenetics; Dietary pattern
ID OXIDATIVE STRESS; ENDOTHELIAL DYSFUNCTION; BREAST-CANCER; ALA-9VAL
   POLYMORPHISM; PROSTATE-CANCER; AGING PROCESS; RISK; ATHEROSCLEROSIS;
   SOD2; ANTIOXIDANTS
AB Evidence suggests an association between obesity and oxidative stress caused by superoxide production. Since the dismutation of superoxide is catalyzed by superoxide dismutase enzymes, we tested the association between obesity and Ala16Val manganese-dependent superoxide dismutase gene (MnSOD) polymorphism. We analyzed 815 free-living community subjects (a parts per thousand yen60 years old) grouped into subjects who were either obese (BMI a parts per thousand yen 30 kg/m(2)) or non-obese (BMI < 25 kg/m(2)). Additionally, we investigated the possible interaction between the Ala16Val MnSOD gene polymorphism and obesity in the modulation of biochemical and nutritional variables. We found a positive association between MnSOD polymorphism and obesity, since higher VV frequency (28.2%) was observed in the obese group (P = 0.002, odds ratio 1.949, 95% CI: 1.223-3.008). This result was independent of sex, age, diabetes, dyslipidemia, hypertension, and metabolic syndrome. A possible biological explanation of the association described here could be a chronic state of superoxide enzyme imbalance present in VV carriers, which could affect differential metabolic pathways contributing to the obese state.
C1 [dos Santos, Greice Feyl; Manica da Cruz, Ivana Beatrice] Univ Fed Santa Maria, Programa Posgrad Ciencias Biol Bioquim Toxicol, Ctr Ciencias Naturais & Exatas, BR-97119900 Santa Maria, RS, Brazil.
   [Echart Montano, Marco Aurelio; Barrio Lera, Juan Pablo] Univ Leon, Dept Ciencias Biomed, Programa Doctorado Biomed, E-24071 Leon, Spain.
   [Valle Gottlieb, Maria Gabriela; Augustin Schwanke, Carla Helena] Pontificia Univ Catolica Rio Grande do Sul, Programa Posgrad Med & Ciencias Saude, Porto Alegre, RS, Brazil.
   [Augustin Schwanke, Carla Helena] Pontificia Univ Catolica Rio Grande do Sul, Inst Gerontol & Geriatr, Porto Alegre, RS, Brazil.
   [Ugalde Marques da Rocha, Maria Izabel; Manica-Cattani, Maria Fernanda; Manica da Cruz, Ivana Beatrice] Univ Fed Santa Maria, Dept Morfol, Lab Biogenom Desenvolvimento, Ctr Ciencias Saude, BR-97900105 Santa Maria, RS, Brazil.
C3 Universidade Federal de Santa Maria (UFSM); Universidad de Leon;
   Pontificia Universidade Catolica Do Rio Grande Do Sul; Pontificia
   Universidade Catolica Do Rio Grande Do Sul; Universidade Federal de
   Santa Maria (UFSM)
RP da Cruz, IBM (corresponding author), Univ Fed Santa Maria, Programa Posgrad Ciencias Biol Bioquim Toxicol, Ctr Ciencias Naturais & Exatas, BR-97119900 Santa Maria, RS, Brazil.
EM ibmcruz@hotmail.com
RI Gottlieb, Maria/J-3100-2013; de Ugalde Marques da Rocha,
   Maria/I-5149-2015; da Cruz, Ivana/G-4329-2012; Barrio, Juan/O-8890-2017;
   Schwanke, Carla/D-1140-2010
OI Schwanke, Carla/0000-0002-0397-771X
FU CNPq [471233/2007-2, 311231/2006-3]; CAPES; FAPERGS
FX The authors thank the team of Project Genesis and Prefeitura Municipal
   de Gravatai for helping in data collection and CNPq (No. 471233/2007-2,
   No. 311231/2006-3), CAPES and FAPERGS for grants and fellowships. Dr. A.
   Leyva provided English editing of the manuscript.
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NR 43
TC 39
Z9 40
U1 0
U2 6
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0300-8177
EI 1573-4919
J9 MOL CELL BIOCHEM
JI Mol. Cell. Biochem.
PD AUG
PY 2009
VL 328
IS 1-2
BP 33
EP 40
DI 10.1007/s11010-009-0071-z
PG 8
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA 465MX
UT WOS:000267592600005
DA 2025-06-11
ER

PT J
AU Sonowal, H
   Ramana, KV
AF Sonowal, Himangshu
   Ramana, Kota, V
TI 4-Hydroxy-Trans-2-Nonenal in the Regulation of Anti-Oxidative and
   Pro-Inflammatory Signaling Pathways
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Review
ID LIPID-PEROXIDATION PRODUCT; GAMMA-GLUTAMYL-TRANSPEPTIDASE;
   GLUTATHIONE-S-TRANSFERASES; SMOOTH-MUSCLE-CELLS; KAPPA-B ACTIVATION;
   OXIDATIVE STRESS; ALDOSE REDUCTASE; GENE-EXPRESSION; NITRIC-OXIDE;
   END-PRODUCT
AB Recent studies indicate that 4-hydroxy-trans-2-nonenal (HNE), a major oxidative stress triggered lipid peroxidation-derived aldehyde, plays a critical role in the pathophysiology of various human pathologies including metabolic syndrome, diabetes, cardiovascular, neurological, immunological, and age-related diseases and various types of cancer. HNE is the most abundant and toxic alpha, beta-unsaturated aldehyde formed during the peroxidation of polyunsaturated fatty acids in a series of free radical-mediated reactions. The presence of an aldehyde group at C1, a double bond between C2 and C3 and a hydroxyl group at C4 makes HNE a highly reactive molecule. These strong reactive electrophilic groups favor the formation of HNE adducts with cellular macromolecules such as proteins and nucleic acids leading to the regulation of various cell signaling pathways and processes involved in cell proliferation, differentiation, and apoptosis. Many studies suggest that the cell-specific intracellular concentrations of HNE dictate the anti-oxidative and pro-inflammatory activities of this important molecule. In this review, we focused on how HNE could alter multiple anti-oxidative defense pathways and pro-inflammatory cytotoxic pathways by interacting with various cell-signaling intermediates.
C1 [Sonowal, Himangshu; Ramana, Kota, V] Univ Texas Med Branch, Dept Biochem & Mol Biol, Galveston, TX 77555 USA.
C3 University of Texas System; University of Texas Medical Branch Galveston
RP Ramana, KV (corresponding author), Univ Texas Med Branch, Dept Biochem & Mol Biol, Galveston, TX 77555 USA.
EM kvramana@utmb.edu
RI Ramana, Kota/C-5460-2012; Sonowal, Himangshu/AAT-7962-2020; Sonowal,
   Himangshu/K-3982-2014
OI Sonowal, Himangshu/0000-0002-2977-7636; Ramana, Kota/0000-0001-6502-7800
FU NIH/NIDDK grant [DK104786]
FX Supported by funding from NIH/NIDDK grant DK104786.
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NR 152
TC 32
Z9 34
U1 0
U2 12
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PD NOV 6
PY 2019
VL 2019
AR 5937326
DI 10.1155/2019/5937326
PG 17
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA JP9PY
UT WOS:000498590200005
PM 31781341
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Zachariah, JP
   Jone, PN
   Agbaje, AO
   Ryan, HH
   Trasande, L
   Perng, W
   Farzan, SF
AF Zachariah, Justin P.
   Jone, Pei-Ni
   Agbaje, Andrew O.
   Ryan, Heather H.
   Trasande, Leonardo
   Perng, Wei
   Farzan, Shohreh F.
TI Environmental Exposures and Pediatric Cardiology: A Scientific Statement
   From the American Heart Association
SO CIRCULATION
LA English
DT Review
DE AHA Scientific Statements; endocrine disruptors; environmental
   pollutants; heart defects, congenital; heart disease risk factors;
   metals, heavy; mucocutaneous lymph node syndrome
ID KAWASAKI-DISEASE; BLOOD-PRESSURE; AIR-POLLUTION; ADOLESCENTS; DEFECTS;
   RISK; CHILDREN; ORIGINS; STRESS; TRENDS
AB Environmental toxicants and pollutants are causes of adverse health consequences, including well-established associations between environmental exposures and cardiovascular diseases. Environmental degradation is widely prevalent and has a long latency period between exposure and health outcome, potentially placing a large number of individuals at risk of these health consequences. Emerging evidence suggests that environmental exposures in early life may be key risk factors for cardiovascular conditions across the life span. Children are a particularly sensitive population for the detrimental effects of environmental toxicants and pollutants given the long-term cumulative effects of early-life exposures on health outcomes, including congenital heart disease, acquired cardiac diseases, and accumulation of cardiovascular disease risk factors. This scientific statement highlights representative examples for each of these cardiovascular disease subtypes and their determinants, focusing specifically on the associations between climate change and congenital heart disease, airborne particulate matter and Kawasaki disease, blood lead levels and blood pressure, and endocrine-disrupting chemicals with cardiometabolic risk factors. Because children are particularly dependent on their caregivers to address their health concerns, this scientific statement highlights the need for clinicians, research scientists, and policymakers to focus more on the linkages of environmental exposures with cardiovascular conditions in children and adolescents.
C1 [Zachariah, Justin P.] Baylor Coll Med, Texas Childrens Hosp, Houston, TX 77030 USA.
   [Jone, Pei-Ni] Northwestern Univ, Feinberg Sch Med, Ann & Robert H Lurie Childrens Hosp Chicago, Chicago, IL USA.
   [Agbaje, Andrew O.] Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Fac Hlth Sci, Sch Med, Joensuu, Finland.
   [Agbaje, Andrew O.] Univ Exeter, Fac Hlth & Life Sci, Childrens Hlth & Exercise Res Ctr, Exeter, England.
   [Farzan, Shohreh F.] Univ Southern Calif, Keck Sch Med, Los Angeles, CA USA.
   [Perng, Wei] Univ Colorado, Colorado Sch Publ Hlth, Dept Epidemiol, Anschutz Med Campus, Aurora, CO USA.
   [Perng, Wei] Univ Colorado, Colorado Sch Publ Hlth, Lifecourse Epidemiol Adipos & Diabet LEAD Ctr, Anschutz Med Campus, Aurora, CO USA.
   [Ryan, Heather H.] Cambridge Hlth Alliance Ambulatory Serv, Cambridge, MA USA.
   [Trasande, Leonardo] New York Univ Grossman Sch Med, New York, NY USA.
C3 Baylor College of Medicine; Baylor College Medical Hospital; Ann &
   Robert H. Lurie Children's Hospital of Chicago; Northwestern University;
   Feinberg School of Medicine; University of Eastern Finland; University
   of Exeter; University of Southern California; Colorado School of Public
   Health; University of Colorado System; University of Colorado Anschutz
   Medical Campus; University of Colorado System; University of Colorado
   Anschutz Medical Campus; Colorado School of Public Health
RP Zachariah, JP (corresponding author), Baylor Coll Med, Texas Childrens Hosp, Houston, TX 77030 USA.
RI Trasande, Leonardo/ABE-6339-2020; Zachariah, Justin/Q-1280-2019; Agbaje,
   Andrew/AAE-9299-2021
OI Zachariah, Justin/0000-0001-7302-2401
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NR 77
TC 6
Z9 6
U1 6
U2 10
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0009-7322
EI 1524-4539
J9 CIRCULATION
JI Circulation
PD MAY 14
PY 2024
VL 149
IS 20
BP e1165
EP e1175
DI 10.1161/CIR.0000000000001234
PG 11
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA ZV0Q0
UT WOS:001277948700002
PM 38618723
DA 2025-06-11
ER

PT J
AU Williams, CR
   Buttfield, B
AF Williams, Claire R.
   Buttfield, Barbara
TI Beyond Individualised Approaches to Diabetes Type 2
SO SOCIOLOGY COMPASS
LA English
DT Article
ID SHIFT WORK; METABOLIC SYNDROME; PRECARIOUS EMPLOYMENT;
   SOCIOECONOMIC-STATUS; RISK-FACTORS; HEALTH; OBESITY; MANAGEMENT;
   MELLITUS; POLITICS
AB Explanations for type 2 diabetes are broadened beyond the individual body and bad lifestyles' to include major institutions, the social and material contexts of food and eating, and employment. Precarious employment, a social determinant of health, encourages changes to food practices, lowers working conditions, worsens health, can bring poverty and increases shift work, a causal risk factor for diabetes. Scientists have played a part in revolutionising foods and technologies which minimise labour and movement. There are excess additives in processed food. Genetic explanations for the higher rates of diabetes in First Nations peoples give way to social explanations: colonial history, British/Euro-American cuisine, food insecurity, trauma and social conditions resulting in chronic stress. Self-management education takes a nutritionist' approach towards food and eating and tends to minimise the social context and skills of those with the condition particularly women workers in poorer social groups who have higher rates of diabetes (T2DM).
C1 [Williams, Claire R.; Buttfield, Barbara] Flinders Univ South Australia, Sociol Discipline, Adelaide, SA 5001, Australia.
C3 Flinders University South Australia
RP Williams, CR (corresponding author), Flinders Univ South Australia, Sociol Discipline, Sch Social & Policy Studies, GPO Box 2100, Adelaide, SA 5001, Australia.
EM claireros@outlook.com
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NR 115
TC 4
Z9 5
U1 0
U2 14
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1751-9020
J9 SOCIOL COMPASS
JI Sociol. Compass
PD JUN
PY 2016
VL 10
IS 6
BP 491
EP 505
DI 10.1111/soc4.12369
PG 15
WC Sociology
WE Social Science Citation Index (SSCI)
SC Sociology
GA DN7OP
UT WOS:000377266800007
OA Bronze
DA 2025-06-11
ER

PT J
AU Greenblum, S
   Carr, R
   Borenstein, E
AF Greenblum, Sharon
   Carr, Rogan
   Borenstein, Elhanan
TI Extensive Strain-Level Copy-Number Variation across Human Gut Microbiome
   Species
SO CELL
LA English
DT Article
ID COMPARATIVE GENOMICS; METABOLIC SYNDROME; ESCHERICHIA-COLI; OXIDATIVE
   STRESS; GENE LOSS; DIVERSITY; BACTERIA; MICE; COLONIZATION; VIRULENCE
AB Within each bacterial species, different strains may vary in the set of genes they encode or in the copy number of these genes. Yet, taxonomic characterization of the human microbiota is often limited to the species level or to previously sequenced strains, and accordingly, the prevalence of intra-species variation, its functional role, and its relation to host health remain unclear. Here, we present a comprehensive large-scale analysis of intra-species copy-number variation in the gut microbiome, introducing a rigorous computational pipeline for detecting such variation directly from shotgun metagenomic data. We uncover a large set of variable genes in numerous species and demonstrate that this variation has significant functional and clinically relevant implications. We additionally infer intra-species compositional profiles, identifying population structure shifts and the presence of yet uncharacterized variants. Our results highlight the complex relationship between microbiome composition and functional capacity, linking metagenome-level compositional shifts to strain-level variation.
C1 [Greenblum, Sharon; Carr, Rogan; Borenstein, Elhanan] Univ Washington, Dept Genome Sci, Seattle, WA 98195 USA.
   [Borenstein, Elhanan] Univ Washington, Dept Comp Engn & Sci, Seattle, WA 98195 USA.
   [Borenstein, Elhanan] Santa Fe Inst, Santa Fe, NM 87501 USA.
C3 University of Washington; University of Washington Seattle; University
   of Washington; University of Washington Seattle; The Santa Fe Institute
RP Borenstein, E (corresponding author), Univ Washington, Dept Genome Sci, Seattle, WA 98195 USA.
EM elbo@uw.edu
OI Greenblum, Sharon/0000-0001-6148-3016
FU New Innovator Award [DP2 AT 007802-01]
FX We thank Peter Turnbaugh, Jay Shendure, Phil Green, Colin Manoil, two
   anonymous reviewers, and the members of the Borenstein Lab for support
   and helpful discussions. This work was supported by a New Innovator
   Award DP2 AT 007802-01 to EB.
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NR 42
TC 172
Z9 221
U1 1
U2 71
PU CELL PRESS
PI CAMBRIDGE
PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA
SN 0092-8674
EI 1097-4172
J9 CELL
JI Cell
PD FEB 12
PY 2015
VL 160
IS 4
BP 583
EP 594
DI 10.1016/j.cell.2014.12.038
PG 12
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA CA8ZE
UT WOS:000349208800004
PM 25640238
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Gu, JK
   Charles, LE
   Burchfiel, CM
   Fekedulegn, D
   Sarkisian, K
   Andrew, ME
   Ma, C
   Violanti, JM
AF Gu, Ja K.
   Charles, Luenda E.
   Burchfiel, Cecil M.
   Fekedulegn, Desta
   Sarkisian, Khachatur
   Andrew, Michael E.
   Ma, Claudia
   Violanti, John M.
TI Long Work Hours and Adiposity Among Police Officers in a US Northeast
   City
SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
LA English
DT Article
ID BODY-MASS INDEX; CORONARY-HEART-DISEASE; METABOLIC SYNDROME; WAIST
   CIRCUMFERENCE; CARDIOVASCULAR RISK; CORTISOL PATTERNS; SLEEP DURATION;
   GHRELIN LEVELS; OVERTIME WORK; HEALTHY-MEN
AB Objective: To investigate the associations between long work hours and adiposity measures in police officers. Methods: Participants included 408 officers from the Buffalo Cardio-Metabolic Occupational Police Stress study who were examined between 2004 and 2009. Total work hours were abstracted from payroll records and questionnaires. Analysis of variance and covariance models were used. Results: Among male officers who worked the midnight shift, mean values of waist circumference and body mass index increased with longer work hours after adjustment for age, physical activity, energy intake, sleep duration, smoking status, police rank, activities after work (eg, child/family care, sports), and household income. Adiposity measures were not associated with work hours among women on any shift. Conclusion: Working longer hours was significantly associated with larger waist circumferences and higher body mass index among male police officers working the midnight shift.
C1 [Gu, Ja K.; Charles, Luenda E.; Burchfiel, Cecil M.; Fekedulegn, Desta; Sarkisian, Khachatur; Andrew, Michael E.; Ma, Claudia] NIOSH, HELD, BEB, Ctr Dis Control & Prevent, Morgantown, WV 26505 USA.
   [Violanti, John M.] SUNY Buffalo, Sch Publ Hlth & Hlth Profess, Dept Social & Prevent Med, Buffalo, NY 14260 USA.
C3 Centers for Disease Control & Prevention - USA; National Institute for
   Occupational Safety & Health (NIOSH); State University of New York
   (SUNY) System; University at Buffalo, SUNY
RP Gu, JK (corresponding author), NIOSH, HELD, BEB, Ctr Dis Control & Prevent, Mailstop L-4050,1095Willowdale Rd, Morgantown, WV 26505 USA.
EM jgu@cdc.gov
RI Charles, Luenda/H-6008-2011
OI /0000-0002-0245-5899; Ma, Claudia C./0000-0001-5639-5978
FU National Institute for Occupational Safety and Health (NIOSH)
   [200-2003-01580]
FX This work was supported by the National Institute for Occupational
   Safety and Health (NIOSH), contract 200-2003-01580.
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NR 65
TC 44
Z9 64
U1 2
U2 25
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1076-2752
EI 1536-5948
J9 J OCCUP ENVIRON MED
JI J. Occup. Environ. Med.
PD NOV
PY 2012
VL 54
IS 11
BP 1374
EP 1381
DI 10.1097/JOM.0b013e31825f2bea
PG 8
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA 035BD
UT WOS:000310915900010
PM 23013913
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Ahles, S
   Cuijpers, I
   Hartgens, F
   Troost, FJ
AF Ahles, S.
   Cuijpers, I
   Hartgens, F.
   Troost, F. J.
TI The Effect of a Citrus and Pomegranate Complex on Physical Fitness and
   Mental Well-Being in Healthy Elderly: A Randomized Placebo-Controlled
   Trial
SO JOURNAL OF NUTRITION HEALTH & AGING
LA English
DT Article
DE Citrus fruit; polyphenols; hesperidin; physical fitness; quality of life
ID QUALITY-OF-LIFE; EXERCISE PERFORMANCE; ENDOTHELIAL FUNCTION; METABOLIC
   SYNDROME; DIETARY NITRATE; BLOOD-PRESSURE; SUPPLEMENTATION; STRENGTH;
   ANTIOXIDANT; POLYPHENOLS
AB Objectives This study investigates whether a citrus and pomegranate complex (CPC) improves physical fitness, mental well-being, and blood biomarkers for oxidative stress and endothelial function in healthy elderly. Design A randomized placebo-controlled cross-over trial. Participants The study included 36 healthy elderly aged 60-75 years old. Intervention and Measurements Participants received four weeks of CPC supplementation and performed the handgrip strength and senior fitness test. Quality of life (QOL) was assessed and blood samples were analyzed for oxidative stress and endothelial function markers. Results After four weeks of CPC supplementation, handgrip strength significantly improved (p=0.019), compared to placebo. Moreover, the thinking, memory, learning, and concentration facets were improved (p=0.042), compared to placebo, and plasma malondialdehyde decreased, compared to placebo (p=0.033). The intervention did not affect senior fitness and the other QOL domains and blood parameters. Conclusion Four weeks of daily CPC supplementation significantly improves handgrip strength and self-evaluated measures of psychological function in healthy older adults. Further research should focus on mechanisms associated with physical performance.
C1 [Ahles, S.] Maastricht Univ, Sch Nutr & Translat Res Metab NUTRIM, Dept Nutr & Movement Sci, NL-6200 MD Maastricht, Netherlands.
   [Ahles, S.] BioActor BV, Maastricht, Netherlands.
   [Cuijpers, I; Troost, F. J.] Maastricht Univ, Ctr Hlth Eating & Food Innovat, Sch Nutr & Translat Res Metab NUTRIM, Div Food Innovat & Hlth, Venlo, Netherlands.
   [Hartgens, F.] Maastricht Univ Med Ctr, Res Inst CAPHRI, Dept Epidemiol, Maastricht, Netherlands.
   [Hartgens, F.] Maastricht Univ Med Ctr, Res Inst CAPHRI, Dept Surg, Maastricht, Netherlands.
   [Hartgens, F.] Sports Med Ctr Maastricht Parkstad, Maastricht, Netherlands.
C3 Maastricht University; Maastricht University; Maastricht University;
   Maastricht University Medical Centre (MUMC); Maastricht University;
   Maastricht University Medical Centre (MUMC)
RP Ahles, S (corresponding author), Maastricht Univ, Sch Nutr & Translat Res Metab NUTRIM, Dept Nutr & Movement Sci, NL-6200 MD Maastricht, Netherlands.
EM s.ahles@maastrichtuniversity.nl
OI Cuijpers, Iris/0000-0003-2936-9947; Troost, Freddy
   J/0000-0002-0018-5557; Ahles, Sanne/0000-0001-8194-529X
FU Province of Limburg, The Netherlands [HEFI-2]; BioActor B.V.
FX Authors IC and FT are supported by the Province of Limburg, The
   Netherlands [grant number HEFI-2]. This research project was supported
   by BioActor B.V.
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NR 65
TC 6
Z9 6
U1 1
U2 7
PU SPRINGER FRANCE
PI PARIS
PA 22 RUE DE PALESTRO, PARIS, 75002, FRANCE
SN 1279-7707
EI 1760-4788
J9 J NUTR HEALTH AGING
JI J. Nutr. Health Aging
PD SEP
PY 2022
VL 26
IS 9
BP 839
EP 846
DI 10.1007/s12603-022-1834-4
EA AUG 2022
PG 8
WC Geriatrics & Gerontology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology; Nutrition & Dietetics
GA 4W5QJ
UT WOS:000836745300001
PM 36156675
OA hybrid
DA 2025-06-11
ER

PT J
AU Hooper, PL
AF Hooper, Philip L.
TI COVID-19 and heme oxygenase: novel insight into the disease and
   potential therapies
SO CELL STRESS & CHAPERONES
LA English
DT Article
DE Heme oxygenase; COVID-19; Therapy; Heat shock proteins; Ventilator;
   Inflammation; Cytokine storm; Smoking; Estrogen; Anesthesia; Elderly
ID STRESS-RESPONSE; PATHOGENESIS; EXPRESSION; SEVOFLURANE; INDUCTION;
   ESTROGEN
AB The COVID-19 pandemic needs therapies that are presently available and safe. We propose that subjects with metabolic syndrome, old age, and male gender have the greatest morbidity and mortality and have low stress proteins, in particular, low intracellular heme oxygenase (HO-1), making them particularly vulnerable to the disease. Additionally, COVID-19's heme reduction may contribute to even lower HO-1. Low-grade inflammation associated with these risk factors contributes to triggering a cytokine storm that spreads to multi-organ failure and near death. The high mortality of those treated with ventilator assistance may partially be explained by ventilator-induced inflammation. The cytoprotective and anti-inflammatory properties of HO-1 can limit the infection's damage. A paradox of COVID-19 hospital admissions data suggests that fewer cigarette-smokers are admitted compared with non-smokers in the general population. This unexpected observation may result from smoke induction of HO-1. Therapies with anti-viral properties that raise HO-1 include certain anesthetics (sevoflurane or isoflurane), hemin, estrogen, statins, curcumin, resveratrol, and melatonin. Controlled trials of these HO-1 inducers should be done in order to prevent or treat COVID-19 disease.
C1 [Hooper, Philip L.] Univ Colorado, Dept Med, Div Endocrinol & Metab, Anschutz Med Campus, Aurora, CO 80045 USA.
C3 University of Colorado System; University of Colorado Anschutz Medical
   Campus
RP Hooper, PL (corresponding author), Univ Colorado, Dept Med, Div Endocrinol & Metab, Anschutz Med Campus, Aurora, CO 80045 USA.
EM phoopermd@gmail.com
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NR 40
TC 46
Z9 47
U1 0
U2 15
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1355-8145
EI 1466-1268
J9 CELL STRESS CHAPERON
JI Cell Stress Chaperones
PD SEP
PY 2020
VL 25
IS 5
SI SI
BP 707
EP 710
DI 10.1007/s12192-020-01126-9
EA JUN 2020
PG 4
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA NL5ZG
UT WOS:000538001900001
PM 32500379
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Ulu, R
   Gozel, N
   Tuzcu, M
   Orhan, C
   Yigit, IP
   Dogukan, A
   Telceken, H
   Üçer, Ö
   Kemeç, Z
   Kaman, D
   Juturu, V
   Sahin, K
AF Ulu, Ramazan
   Gozel, Nevzat
   Tuzcu, Mehmet
   Orhan, Cemal
   Yigit, Irem Pembegul
   Dogukan, Ayhan
   Telceken, Hafize
   Ucer, Ozlem
   Kemec, Zeki
   Kaman, Dilara
   Juturu, Vijaya
   Sahin, Kazim
TI The effects of Mucuna pruriens on the renal oxidative stress and
   transcription factors in high-fructose-fed rats
SO FOOD AND CHEMICAL TOXICOLOGY
LA English
DT Article
DE Mucuna pruriens; High-fructose; Transcription factors
ID CHRONIC KIDNEY-DISEASE; NF-KAPPA-B; METABOLIC SYNDROME; ANTIOXIDANT
   ACTIVITIES; INSULIN SENSITIVITY; SEED EXTRACT; INJURY; INFLAMMATION;
   PROGRESSION; DAMAGE
AB In the present study, we evaluated the effects of M. pruriens administration on metabolic parameters, oxidative stress and kidney nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappa B) and nuclear factor (erythroid-derived 2)-like 2 (Nrf2) signaling pathways in high-fructose fed rats. Male rats (n = 28) were divided into 4 groups as control, M. pruriens, fructose, and M. pruriens plus fructose. All rats were fed a standard diet supplemented or no supplemented with M. pruriens (200 mg/kg/d by gavage). Fructose was given in drinking water for 8 weeks. High fructose consumption led to an increase in the serum level of glucose, triglyceride, urea and renal malondialdehyde (MDA) levels. Although M. pruriens treatment reduced triglyceride and MDA levels, it did not affect other parameters. M. pruriens supplementation significantly decreased the expression of NF-kappa B and decreased expression of Nrf2 and HO-1 proteins in the kidney. This study showed that the adverse effects of high fructose were alleviated by M. pruriens supplementation via modulation of the expression of kidney nuclear transcription factors in rats fed high fructose diet.
C1 [Ulu, Ramazan; Dogukan, Ayhan; Kemec, Zeki] Firat Univ, Sch Med, Dept Nephrol, Elazig, Turkey.
   [Gozel, Nevzat] Firat Univ, Sch Med, Dept Internal Med, Elazig, Turkey.
   [Tuzcu, Mehmet] Firat Univ, Dept Biol, Fac Sci, Elazig, Turkey.
   [Orhan, Cemal; Sahin, Kazim] Firat Univ, Dept Anim Nutr, Fac Vet Sci, Elazig, Turkey.
   [Yigit, Irem Pembegul] Training & Res Hosp, Dept Nephrol, Malatya, Turkey.
   [Telceken, Hafize] Firat Univ, Dept Chem, Fac Sci, Elazig, Turkey.
   [Ucer, Ozlem] Firat Univ, Sch Med, Dept Pathol, Elazig, Turkey.
   [Kaman, Dilara] Firat Univ, Sch Med, Dept Biochem, Elazig, Turkey.
   [Juturu, Vijaya] OrrutiAct Hlth Technol Inc, Res & Dev, Morristown, NJ USA.
C3 Firat University; Firat University; Firat University; Firat University;
   Firat University; Firat University; Firat University
RP Sahin, K (corresponding author), Firat Univ, Vet Fac, TR-23119 Elazig, Turkey.
EM ksahin@firat.edu.tr
RI Pembegul, Irem/AAB-6645-2022; ulu, ramazan/V-9751-2018; Dogukan,
   Ayhan/W-2518-2018; kaman, dilara/V-9024-2018; Orhan, Cemal/Q-2086-2015;
   Sahin, Kazim/D-5625-2009; Tuzcu, Mehmet/H-2953-2018
OI Orhan, Cemal/0000-0003-4138-7689; Sahin, Kazim/0000-0001-9542-5244;
   Tuzcu, Mehmet/0000-0002-1329-3143; Gozel, Nevzat/0000-0001-7326-6860
FU Turkish Academy of Sciences [2017-01]
FX M. pruriens was provided by OmniActive Health Technologies Inc.
   (Pune-India). This work was supported in part by the Turkish Academy of
   Sciences (2017-01).
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NR 40
TC 13
Z9 13
U1 0
U2 11
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0278-6915
EI 1873-6351
J9 FOOD CHEM TOXICOL
JI Food Chem. Toxicol.
PD AUG
PY 2018
VL 118
BP 526
EP 531
DI 10.1016/j.fct.2018.05.061
PG 6
WC Food Science & Technology; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Toxicology
GA GR5XD
UT WOS:000442714300054
PM 29860019
DA 2025-06-11
ER

PT J
AU He, GF
   Zhang, YW
   Lee, JH
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AF He, Guifen
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   Lee, Jun-Ho
   Zeng, Shelya X.
   Wang, Yunyuan V.
   Luo, Zhijun
   Dong, X. Charlie
   Viollet, Benoit
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   Lu, Hua
TI AMP-Activated Protein Kinase Induces p53 by Phosphorylating MDMX and
   Inhibiting Its Activity
SO MOLECULAR AND CELLULAR BIOLOGY
LA English
DT Article
ID UBIQUITIN LIGASE ACTIVITY; TUMOR-SUPPRESSOR P53; CELL-CYCLE ARREST;
   DNA-DAMAGE; RIBOSOMAL-STRESS; IN-VIVO; INSULIN SENSITIVITY; METABOLIC
   SYNDROME; ONCOPROTEIN MDM2; METFORMIN
AB AMP-activated protein kinase (AMPK) has been shown to activate p53 in response to metabolic stress. However, the underlying mechanisms remain unclear. Here we show that metabolic stresses induce AMPK-mediated phosphorylation of human MDMX on Ser342 in vitro and in cells, leading to enhanced association between MDMX and 14-3-3. This markedly inhibits p53 ubiquitylation and significantly stabilizes and activates p53. By striking contrast, no phosphorylation of MDM2 by AMPK was noted. AMPK-mediated MDMX phosphorylation, MDMX-14-3-3 binding, and p53 activation were drastically reduced in mouse embryo fibroblasts harboring endogenous MDMX with S341A (mouse homologue of human serine 342), S367A, and S402A (mouse homologue of human serine 403) mutations. Moreover, deficiency of AMPK prevented MDMX-14-3-3 interaction and p53 activation. The activation of p53 through AMPK-mediated MDMX phosphorylation and inactivation was further confirmed by using cell and animal model systems with two AMPK activators, metformin and salicylate (the active form of aspirin). Together, the results unveil a mechanism by which metabolic stresses activate AMPK, which, in turn, phosphorylates and inactivates MDMX, resulting in p53 stabilization and activation.
C1 [He, Guifen; Zhang, Yi-Wei; Lee, Jun-Ho; Zeng, Shelya X.; Lu, Hua] Tulane Univ, Sch Med, Dept Biochem & Mol Biol, New Orleans, LA 70112 USA.
   [He, Guifen; Zhang, Yi-Wei; Lee, Jun-Ho; Zeng, Shelya X.; Lu, Hua] Tulane Canc Ctr, New Orleans, LA USA.
   [Dong, X. Charlie] Indiana Univ Sch Med, Simon Canc Ctr, Dept Biochem & Mol Biol, Indiana, PA USA.
   [Wang, Yunyuan V.; Wahl, Geoffrey M.] Salk Inst Biol Studies, Gene Express Lab, La Jolla, CA 92037 USA.
   [Luo, Zhijun] Boston Univ, Sch Med, Dept Biochem, Boston, MA 02118 USA.
   [Viollet, Benoit] INSERM, U1016, Inst Cochin, Paris, France.
   [Lee, Jun-Ho] Daejeon Univ, Dept Emergency Med Technol, Taejon, South Korea.
   [Viollet, Benoit] CNRS, UMR8104, Paris, France.
   [Viollet, Benoit] Univ Paris 05, Sorbonne Paris Cite, Paris, France.
C3 Tulane University; Tulane University; Tulane University Hospital; Salk
   Institute; Boston University; Institut National de la Sante et de la
   Recherche Medicale (Inserm); Universite Paris Cite; Daejeon University;
   Universite Paris Cite; Centre National de la Recherche Scientifique
   (CNRS); CNRS - National Institute for Biology (INSB); Universite Paris
   Cite
RP Lu, H (corresponding author), Tulane Univ, Sch Med, Dept Biochem & Mol Biol, 1430 Tulane Ave, New Orleans, LA 70112 USA.
EM hlu2@tulane.edu
RI Luo, Zhijun/AAE-9302-2019; Lee, Jun/AAI-1007-2020; Viollet,
   Benoit/O-6927-2017
OI LUO, ZHIJUN/0000-0001-8105-5289; Viollet, Benoit/0000-0002-0121-0224
FU NIH-NCI [CA127724, CA095441, CA129828, CA 172468, CA 061449]
FX H.L. was supported by NIH-NCI grants CA127724, CA095441, CA129828, and
   CA 172468. G. M. W. was supported by NIH-NCI grant CA 061449.
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NR 72
TC 88
Z9 99
U1 1
U2 25
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0270-7306
EI 1098-5549
J9 MOL CELL BIOL
JI Mol. Cell. Biol.
PD JAN
PY 2014
VL 34
IS 2
BP 148
EP 157
DI 10.1128/MCB.00670-13
PG 10
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA 302DM
UT WOS:000330581800001
PM 24190973
OA Green Published
DA 2025-06-11
ER

PT J
AU Rzheshevsky, AV
AF Rzheshevsky, A. V.
TI Fatal "Triad": Lipotoxicity, oxidative stress, and phenoptosis
SO BIOCHEMISTRY-MOSCOW
LA English
DT Article
DE metabolic syndrome; insulin resistance; obesity; lipotoxicity; oxidative
   stress; phenoptosis; programmed aging
ID ADIPOSE-TISSUE; EXPRESSION; RESISTIN; OBESITY; NECROSIS
AB Negative factors, such as the "magnificent" five that includes alcoholism, smoking, unhealthy food, lack of movement, and negative emotions, accompany a person almost from birth and trigger powerful internal biochemical reactions leading to disastrous consequences. Those new deleterious reactions force the organism to mobilize all of its internal reserves to neutralize, at least temporarily, the destructive effects of these negative factors. As a result of this continuous struggle for survival, body parts degenerate, starting from connective tissue protein molecules to entire newly formed organs (such as adipose tissue). Today we can state with certainty that the reason for the majority of widespread pathologies causing premature aging and death, such as atherosclerosis and arterial hypertension, is exactly those external negative factors that a person voluntary introduces into their life. However, the margin of safety that Nature enclosed in the human body is really amazing, allowing light-minded and self-destructive people to live up to 60 years and longer. It is quite possible that the lifespan will increase up to 100 years and more if a person stops destroying themself with negative emotions and bad habits, including unhealthy food and overeating. This article examines possible interconnection between unhealthy overeating and the theory of programmed aging and phenoptosis.
C1 Restorat Med Ctr, UA-49000 Dnepropetrovsk, Ukraine.
RP Rzheshevsky, AV (corresponding author), Restorat Med Ctr, Ul Mechnikova 8, UA-49000 Dnepropetrovsk, Ukraine.
EM alex-rjechewsky@mail.ru
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NR 42
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Z9 22
U1 0
U2 9
PU MAIK NAUKA/INTERPERIODICA/SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013-1578 USA
SN 0006-2979
EI 1608-3040
J9 BIOCHEMISTRY-MOSCOW+
JI Biochem.-Moscow
PD SEP
PY 2013
VL 78
IS 9
BP 991
EP 1000
DI 10.1134/S0006297913090046
PG 10
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 217QT
UT WOS:000324375500004
PM 24228920
DA 2025-06-11
ER

PT J
AU Murakami, M
   Tognini, P
AF Murakami, Mari
   Tognini, Paola
TI Molecular Mechanisms Underlying the Bioactive Properties of a Ketogenic
   Diet
SO NUTRIENTS
LA English
DT Article
DE ketogenic diet; beta-hydroxybutyrate; epigenetics; circadian clock;
   microbiome; neurological disorder
ID BETA-HYDROXYBUTYRATE; KETONE-BODIES; GUT MICROBIOTA; HIGH-FAT; CIRCADIAN
   CLOCK; NLRP3 INFLAMMASOME; OXIDATIVE STRESS; FUEL METABOLISM; DIABETIC
   KIDNEY; PROTEIN
AB The consumption of a high-fat, low-carbohydrate diet (ketogenic diet) has diverse effects on health and is expected to have therapeutic value in neurological disorders, metabolic syndrome, and cancer. Recent studies have shown that a ketogenic diet not only pronouncedly shifts the cellular metabolism to pseudo-starvation, but also exerts a variety of physiological functions on various organs through metabolites that act as energy substrates, signaling molecules, and epigenetic modifiers. In this review, we highlight the latest findings on the molecular mechanisms of a ketogenic diet and speculate on the significance of these functions in the context of the epigenome and microbiome. Unraveling the molecular basis of the bioactive effects of a ketogenic diet should provide solid evidence for its clinical application in a variety of diseases including cancer.
C1 [Murakami, Mari] Osaka Univ, Grad Sch Med, Dept Microbiol & Immunol, Osaka 5650871, Japan.
   [Murakami, Mari] Osaka Univ, Immunol Frontier Res Ctr, Osaka 5650871, Japan.
   [Tognini, Paola] Univ Pisa, Dept Translat Res & New Technol Med & Surg, I-56126 Pisa, Italy.
   [Tognini, Paola] Scuola Normale Super Pisa, Lab Biol, I-56126 Pisa, Italy.
C3 The University of Osaka; The University of Osaka; University of Pisa;
   Scuola Normale Superiore di Pisa
RP Murakami, M (corresponding author), Osaka Univ, Grad Sch Med, Dept Microbiol & Immunol, Osaka 5650871, Japan.; Murakami, M (corresponding author), Osaka Univ, Immunol Frontier Res Ctr, Osaka 5650871, Japan.
EM marim@ongene.med.osaka-u.ac.jp; paola.tognini@sns.it
RI Murakami, Mari/AAC-8125-2022
OI Tognini, Paola/0000-0001-7055-4701
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NR 131
TC 24
Z9 24
U1 1
U2 31
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD FEB
PY 2022
VL 14
IS 4
AR 782
DI 10.3390/nu14040782
PG 17
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA ZK8KU
UT WOS:000763233800001
PM 35215432
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Elhence, A
   Shalimar
AF Elhence, Anshuman
   Shalimar
TI Treatment of non-alcoholic fatty liver disease - Current perspectives
SO INDIAN JOURNAL OF GASTROENTEROLOGY
LA English
DT Review
DE Body mass index; Dyslipidemia; Epidemiology; Metabolic syndrome; Obesity
ID UNITED-STATES; WEIGHT-LOSS; HEPATOCELLULAR-CARCINOMA; INSULIN
   SENSITIVITY; BARIATRIC SURGERY; HEPATIC STEATOSIS; PHYSICAL-ACTIVITY;
   LOW-CARBOHYDRATE; MORBIDLY OBESE; DOUBLE-BLIND
AB Therapeutics aimed at treating non-alcoholic fatty liver disease (NAFLD) target the pathogenic process from deranged metabolism leading to steatosis to cell stress and death, leading to a cascade of inflammation and fibrosis, ultimately culminating into cirrhosis. The development of drugs for management of NAFLD has bloomed over the past decade, although at present there is no approved pharmacological agent for its management. Not all patients with the disease progress to cirrhosis and decompensation; hence, treatment specifically is provided for those with a high risk of progression such as those with biopsy-proven steatohepatitis or fibrosis. Along with disease-specific management, all patients must receive therapies directed at risk factors such as dyslipidemia, insulin resistance, type 2 diabetes mellitus and obesity. Comorbidities such as cardiovascular disease, sleep apnoea and chronic kidney disease need management. A current perspective on the therapeutic options is detailed in this review.
C1 [Elhence, Anshuman; Shalimar] All India Inst Med Sci, Dept Gastroenterol, Human Nutr Unit, Room 127,1st Floor, New Delhi 110029, India.
C3 All India Institute of Medical Sciences (AIIMS) New Delhi
RP Shalimar (corresponding author), All India Inst Med Sci, Dept Gastroenterol, Human Nutr Unit, Room 127,1st Floor, New Delhi 110029, India.
EM drshalimar@yahoo.com
RI , Anshuman/AAR-8438-2021; Shalimar, ./J-5686-2016
OI Shalimar, ./0000-0003-1247-437X
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NR 78
TC 20
Z9 21
U1 1
U2 9
PU SPRINGER INDIA
PI NEW DELHI
PA 7TH FLOOR, VIJAYA BUILDING, 17, BARAKHAMBA ROAD, NEW DELHI, 110 001,
   INDIA
SN 0254-8860
EI 0975-0711
J9 INDIAN J GASTROENTER
JI Indian J. Gastroenterol.
PD FEB
PY 2020
VL 39
IS 1
SI SI
BP 22
EP 31
DI 10.1007/s12664-020-01021-2
PG 10
WC Gastroenterology & Hepatology
WE Emerging Sources Citation Index (ESCI)
SC Gastroenterology & Hepatology
GA LI5QR
UT WOS:000529540800003
PM 32152902
DA 2025-06-11
ER

PT J
AU Heydemann, A
AF Heydemann, Ahlke
TI An Overview of Murine High Fat Diet as a Model for Type 2 Diabetes
   Mellitus
SO JOURNAL OF DIABETES RESEARCH
LA English
DT Review
ID INSULIN-RESISTANCE; ADIPOSE-TISSUE; MOUSE MODELS; METABOLIC SYNDROME;
   GLUCOSE-TOLERANCE; HEART-FAILURE; MITOCHONDRIAL-FUNCTION; MUSCLE
   REGENERATION; CARDIAC-HYPERTROPHY; OXIDATIVE STRESS
AB Type 2 diabetes mellitus (T2DM) is a worldwide epidemic, which by all predictions will only increase. To help in combating the devastating array of phenotypes associated with T2DMa highly reproducible and human disease-similar mouse model is required for researchers. The current options are genetic manipulations to cause T2DM symptoms or diet induced obesity and T2DM symptoms. These methods to model human T2DM have their benefits and their detractions. As far as modeling the majority of T2DM cases, HFD establishes the proper etiological, pathological, and treatment options. A limitation of HFD is that it requires months of feeding to achieve the full spectrum of T2DM symptoms and no standard protocol has been established. This paper will attempt to rectify the last limitation and argue for a standard group of HFD protocols and standard analysis procedures.
C1 [Heydemann, Ahlke] Univ Illinois, Chicago, IL 60612 USA.
   [Heydemann, Ahlke] Ctr Cardiovasc Res, Chicago, IL 60612 USA.
C3 University of Illinois System; University of Illinois Chicago;
   University of Illinois Chicago Hospital
RP Heydemann, A (corresponding author), Univ Illinois, Chicago, IL 60612 USA.; Heydemann, A (corresponding author), Ctr Cardiovasc Res, Chicago, IL 60612 USA.
EM ahlkeh@uic.edu
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NR 112
TC 260
Z9 298
U1 12
U2 76
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2314-6745
EI 2314-6753
J9 J DIABETES RES
JI J. Diabetes Res.
PY 2016
VL 2016
AR 2902351
DI 10.1155/2016/2902351
PG 14
WC Endocrinology & Metabolism; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Research & Experimental Medicine
GA DT4IN
UT WOS:000381443500001
PM 27547764
OA gold, Green Published, Green Submitted
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Berezin, A
   Zulli, A
   Kerrigan, S
   Petrovic, D
   Kruzliak, P
AF Berezin, Alexander
   Zulli, Anthony
   Kerrigan, Steve
   Petrovic, Daniel
   Kruzliak, Peter
TI Predictive role of circulating endothelial-derived microparticles in
   cardiovascular diseases
SO CLINICAL BIOCHEMISTRY
LA English
DT Review
DE Endothelial-derived microparticles; Cardiovascular diseases; Metabolic
   diseases; Risk stratification
ID AMERICAN-HEART-ASSOCIATION; TISSUE FACTOR; IN-VITRO; EXTRACELLULAR
   VESICLES; HYPERTENSIVE PATIENTS; VASCULAR ENDOTHELIUM;
   ATRIAL-FIBRILLATION; OXIDATIVE STRESS; MISSING LINK; CELLS
AB Endothelial-derived microparticles (EMPs) are a novel biological marker of endothelium injury and vasomotion disorders that are involved in pathogenesis of cardiovascular, metabolic, and inflammatory diseases. Circulating levels of EMPs are thought to reflect a balance between cell stimulation, proliferation, apoptosis, and cell death. Increased EMPs may be defined in several cardiovascular diseases, such as stable and unstable coronary artery disease, acute and chronic heart failure, hypertension, arrhythmias, thromboembolism, asymptomatic atherosclerosis as well as renal failure, metabolic disorders (including type two diabetes mellitus, abdominal obesity, metabolic syndrome, insulin resistance) and dyslipidemia. This review highlights the controversial opinions regarding impact of circulating EMPs in major cardiovascular and metabolic diseases and summarizes the perspective implementation of the EMPs in risk stratification models. (C) 2015 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
C1 [Berezin, Alexander] State Med Univ, Dept Internal Med, Zaporozhe, Ukraine.
   [Zulli, Anthony] Victoria Univ, Coll Hlth & Biomed, Ctr Chron Dis Prevent & Management, St Albans, Australia.
   [Kerrigan, Steve] Royal Coll Surgeons Ireland, Mol & Cellular Therapeut Dept, Dublin 2, Ireland.
   [Petrovic, Daniel] Univ Ljubljana, Sch Med, Dept Histol & Embryol, Ljubljana, Slovenia.
   [Kruzliak, Peter] Masaryk Univ, St Annes Univ Hosp, Int Clin Res Ctr, Brno 65691, Czech Republic.
C3 Zaporizhzhia State Medical University; Victoria University; Royal
   College of Surgeons - Ireland; University of Ljubljana; Masaryk
   University Brno; St. Anne's University Hospital Brno (FNUSA); St. Anne's
   University Hospital Brno (FNUSA-ICRC)
RP Kruzliak, P (corresponding author), Masaryk Univ, St Annes Univ Hosp, Int Clin Res Ctr, Dept Cardiovasc Dis, Pekarska 53, Brno 65691, Czech Republic.
EM peter.kruzliak@savba.sk
RI Berezin, Alexander/B-9032-2014
OI Berezin, Alexander/0000-0002-0446-3999
FU European Regional Development Fund-Project FNUSA-ICRC
   [CZ.1.05/1.1.00/02.0123]
FX This study was elaborated within the grant of the European Regional
   Development Fund-Project FNUSA-ICRC (No. CZ.1.05/1.1.00/02.0123).
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NR 89
TC 71
Z9 81
U1 0
U2 32
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0009-9120
EI 1873-2933
J9 CLIN BIOCHEM
JI Clin. Biochem.
PD JUN
PY 2015
VL 48
IS 9
BP 562
EP 568
DI 10.1016/j.clinbiochem.2015.02.003
PG 7
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA CJ1AN
UT WOS:000355213600003
PM 25697107
DA 2025-06-11
ER

PT J
AU Leiter, EH
   Lee, CH
AF Leiter, EH
   Lee, CH
TI Mouse models and the genetics of diabetes - Is there evidence for
   genetic overlap between type 1 and type 2 diabetes?
SO DIABETES
LA English
DT Article; Proceedings Paper
CT 6th Servier-IGIS Symposium
CY MAR 10-13, 2005
CL St Jean Cap Ferrat, FRANCE
ID BETA-CELL APOPTOSIS; NOD MICE; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   ALLOXAN-RESISTANT; PANCREATIC-ISLETS; SUSCEPTIBLE MICE; LEPTIN RECEPTOR;
   C57BL/KSJ MICE; ALR/LT MICE
AB In humans, both type 1 and type 2 diabetes exemplify genetically heterogeneous complex diseases in which epigenetic factors contribute to underlying genetic susceptibility. Extended human pedigrees often show inheritance of both diabetes types. A common pathophysiological denominator in both disease forms is pancreatic beta-cell exposure to proinflammatory cytokines. Hence, it is intuitive that systemically expressed genes regulating beta-cell ability to withstand chronic diabetogenic stress may represent a component of shared susceptibility to both major disease forms. In this review, the authors assemble evidence from genetic experiments using animal models developing clearly distinct diabetes syndromes to inquire whether some degree of overlap in genes contributing susceptibility can be demonstrated. The conclusion is that although overlap exists in the pathophysiological insults leading to beta-cell destruction in the currently studied rodent models, the genetic bases seem quite distinct.
C1 Jackson Lab, Bar Harbor, ME 04609 USA.
   Korea Res Inst Biosci & Biotechnol, Taejon, South Korea.
C3 Jackson Laboratory; Korea Research Institute of Bioscience &
   Biotechnology (KRIBB)
RP Leiter, EH (corresponding author), Jackson Lab, 600 Main St, Bar Harbor, ME 04609 USA.
EM ehl@jax.org
RI Lee, Chul-Ho/MBV-8603-2025
FU NCI NIH HHS [CA-34196] Funding Source: Medline; NIDDK NIH HHS [DK36175,
   DK27722] Funding Source: Medline
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NR 68
TC 16
Z9 21
U1 0
U2 4
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0012-1797
J9 DIABETES
JI Diabetes
PD DEC
PY 2005
VL 54
SU 2
BP S151
EP S158
DI 10.2337/diabetes.54.suppl_2.S151
PG 8
WC Endocrinology & Metabolism
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 990EZ
UT WOS:000233727300021
PM 16306333
OA Bronze
DA 2025-06-11
ER

PT J
AU Darapaneni, H
   Lakhanpal, S
   Chhayani, H
   Parikh, K
   Patel, M
   Gupta, V
   Anamika, F
   Munjal, R
   Jain, R
AF Darapaneni, Haritha
   Lakhanpal, Samridhi
   Chhayani, Hiren
   Parikh, Kinna
   Patel, Meet
   Gupta, Vasu
   Anamika, Fnu
   Munjal, Ripudaman
   Jain, Rohit
TI Shedding light on weight loss: A narrative review of medications for
   treating obesity
SO ROMANIAN JOURNAL OF INTERNAL MEDICINE
LA English
DT Article
DE Cardiovascular diseases; obesity; weight loss medications; cancer;
   atherosclerosis
ID CARDIOVASCULAR-DISEASE; PERICARDIAL FAT; ENDOTHELIAL DYSFUNCTION;
   SCIENTIFIC STATEMENT; INSULIN-RESISTANCE; OXIDATIVE STRESS;
   RISK-FACTORS; TOLERABILITY; SAFETY; ACCUMULATION
AB Obesity and overweight are the major risk factors for numerous chronic diseases, including cardiovascular diseases such as heart disease and stroke, which are the leading causes of death worldwide. The prevalence of obesity has dramatically risen in both developed and developing countries, making it a significant public health concern and a global crisis. Despite lifestyle modifications being the first-line treatment, the high risk of relapse has led to a growing interest in non-invasive pharmacotherapeutic interventions to achieve and maintain weight loss and reverse the growth of the obesity epidemic. Cardiovascular diseases and cancer account for the highest mortality rates among other comorbidities associated with obesity and overweight. Excess and abnormally deposited adipose tissue secretes various inflammatory mediators, leading to cardiovascular diseases and cancers. Weight loss of 5-10% significantly reduces cardiometabolic risk. Medications currently approved in the USA for long-term management of obesity are orlistat, naltrexone, bupropion, phentermine/topiramate, and Glucagon Like Peptide-1 (GLP-1) agonists such as liraglutide and semaglutide. The benefit-to-risk of medications, comorbidities, and individual responses should guide the treatment decisions. The article provides a comprehensive overview and discussion of several weight loss medications used previously and currently, including their efficacy, mechanisms of action, and side effects.
C1 [Darapaneni, Haritha] NTRUHS Govt Guntur Med Coll, Guntur, India.
   [Lakhanpal, Samridhi] Govt Med Coll, Amritsar, Punjab, India.
   [Chhayani, Hiren; Parikh, Kinna] GMERS Med Coll, Gandhinagar 382012, Gujarat, India.
   [Patel, Meet] Tianjin Med Univ, Tianjin, Peoples R China.
   [Gupta, Vasu] Dayanand Med Coll & Hosp, Ludhiana, India.
   [Anamika, Fnu] Univ Coll Med Sci, New Delhi, India.
   [Munjal, Ripudaman] San Joaquin Gen Hosp, French Camp, CA USA.
   [Jain, Rohit] Penn State Milton S Hershey Med Ctr, Hershey, PA USA.
C3 Tianjin Medical University; Dayanand Medical College & Hospital;
   University of Delhi; University College of Medical Sciences;
   Pennsylvania Commonwealth System of Higher Education (PCSHE);
   Pennsylvania State University; Penn State Health
RP Chhayani, H (corresponding author), GMERS Med Coll, Gandhinagar 382012, Gujarat, India.
EM hirenchhayani131@gmail.com
RI Patel, Meet/JXY-0841-2024; Munjal, Ripudaman Singh/IZQ-2981-2023
OI Chhayani, Hiren/0009-0000-3276-306X; Patel, Meet/0000-0002-6660-8903;
   Munjal, Ripudaman Singh/0000-0002-0728-6625
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NR 55
TC 3
Z9 3
U1 3
U2 6
PU SCIENDO
PI WARSAW
PA BOGUMILA ZUGA 32A, WARSAW, MAZOVIA, POLAND
SN 1582-3296
EI 2501-062X
J9 ROM J INTERN MED
JI Rom. J. Intern. Med.
PD MAR 1
PY 2024
VL 62
IS 1
DI 10.2478/rjim-2023-0023
EA SEP 2023
PG 10
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA LU1E1
UT WOS:001074297500001
PM 37752761
OA gold
DA 2025-06-11
ER

PT J
AU Liu, YF
   Zheng, KF
   Wang, HH
   Liu, H
   Zheng, KY
   Zhang, JJ
   Han, L
   Tu, SH
   Wang, YX
AF Liu, Yafei
   Zheng, Kaifeng
   Wang, Huanhuan
   Liu, Hong
   Zheng, Kunyang
   Zhang, Junjun
   Han, Liang
   Tu, Shenghao
   Wang, Yaoxian
TI Natural Bioactive Compounds: Emerging Therapies for Hyperuricemia
SO AMERICAN JOURNAL OF CHINESE MEDICINE
LA English
DT Article
DE Bioactive Compounds; Hyperuricemia; Xanthine Oxidase; Uric Acid
   Transporter; Flavonoids; Stilbenes
ID OXONATE-INDUCED HYPERURICEMIA; XANTHINE-OXIDASE INHIBITORS; ORGANIC ION
   TRANSPORTERS; SERUM URIC-ACID; INFLAMMASOME ACTIVATION; KIDNEY
   INFLAMMATION; RENAL DYSFUNCTION; OXIDATIVE STRESS; INJURY; QUERCETIN
AB Hyperuricemia is a crucial feature of metabolic syndrome, characterized by elevated uric acid that causes urate crystal deposits in joints, kidneys, and subcutaneous tissues, resulting in gout and hyperuricemic nephropathy. The primary causes of uric acid metabolism disorder include overproduction and reduced excretion. The majority of uric acid in human body is derived from the breakdown of purine nucleotides. Overproduction of uric acid can result from increased concentration or activity of xanthine oxidase, the key enzyme responsible for uric acid synthesis. Alterations in the activity of proteins responsible for uric acid reabsorption and excretion can also affect serum uric acid. Many bioactive compounds derived from natural plants have been shown to inhibit xanthine oxidase activity to reduce uric acid production, modulate the activity of transport proteins to promote uric acid excretion, or alleviate oxidative stress and inflammation through various signaling pathways. These properties have garnered significant attention from researchers. In this paper, we first introduce the pathophysiological mechanisms of hyperuricemia, then summarize bioactive compounds with urate-lowering effects, and discuss their potential applications in treating hyperuricemia and its complications.
C1 [Liu, Yafei; Zheng, Kaifeng; Wang, Huanhuan; Liu, Hong; Zheng, Kunyang; Zhang, Junjun] Zhengzhou Univ, Affiliated Hosp 1, Dept Nephrol, 1 Jianshe East Rd, Zhengzhou 450001, Henan, Peoples R China.
   [Zheng, Kaifeng] Zhengzhou Univ, Acad Med Sci, Applicat Ctr Precis Med, Zhengzhou 450001, Henan, Peoples R China.
   [Han, Liang; Tu, Shenghao] Huazhong Univ Sci & Technol, Tongji Hosp, Inst Integrated Tradit Chinese & Western Med, Tongji Med Coll, Wuhan 430030, Hubei, Peoples R China.
   [Wang, Yaoxian] Henan Univ Tradit Chinese Med, Zhengzhou 450001, Henan, Peoples R China.
C3 Zhengzhou University; Zhengzhou University; Huazhong University of
   Science & Technology; Henan University of Traditional Chinese Medicine
RP Liu, YF (corresponding author), Zhengzhou Univ, Affiliated Hosp 1, Dept Nephrol, 1 Jianshe East Rd, Zhengzhou 450001, Henan, Peoples R China.
EM yfliu@zzu.edu.cn
RI Kaifeng, Zheng/AAJ-8257-2021; Liu, Hong/HNP-2299-2023; Liu,
   Ya-Fei/B-1916-2016
OI Liu, Ya-Fei/0000-0002-4141-5259; Zheng, Kaifeng/0009-0000-7031-3051
FU National Natural Science Foundation of China [82174154]
FX This work was supported by the National Natural Science Foundation of
   China (82174154).
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NR 113
TC 1
Z9 1
U1 34
U2 39
PU WORLD SCIENTIFIC PUBL CO PTE LTD
PI SINGAPORE
PA 5 TOH TUCK LINK, SINGAPORE 596224, SINGAPORE
SN 0192-415X
EI 1793-6853
J9 AM J CHINESE MED
JI Am. J. Chin. Med.
PY 2024
VL 52
IS 06
BP 1863
EP 1885
DI 10.1142/S0192415X24500733
EA NOV 2024
PG 23
WC Integrative & Complementary Medicine; Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine; General & Internal Medicine
GA N2Y7L
UT WOS:001357668600001
PM 39558557
DA 2025-06-11
ER

PT J
AU Jiang, ZM
   Wang, Y
   Zhao, X
   Cui, HY
   Han, MY
   Ren, XH
   Gang, XK
   Wang, GX
AF Jiang, Zongmiao
   Wang, Yao
   Zhao, Xue
   Cui, Haiying
   Han, Mingyue
   Ren, Xinhua
   Gang, Xiaokun
   Wang, Guixia
TI Obesity and chronic kidney disease
SO AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
LA English
DT Review
DE chronic kidney disease; glomerulus; obesity; proximal tubular; weight
   loss
ID BODY-MASS INDEX; ANGIOTENSIN-ALDOSTERONE SYSTEM; DIET-INDUCED OBESITY;
   STAGE RENAL-DISEASE; INSULIN-RESISTANCE; METABOLIC SYNDROME; BARIATRIC
   SURGERY; ADIPOSE-TISSUE; WEIGHT-LOSS; OXIDATIVE STRESS
AB The prevalence of obesity has increased dramatically during the past decades, which has been a major health problem. Since 1975, the number of people with obesity worldwide has nearly tripled. An increasing number of studies find obesity as a driver of chronic kidney disease (CKD) progression, and the mechanisms are complex and include hemodynamic changes, inflammation, oxidative stress, and activation of the renin-angiotensin-aldosterone system (RAAS). Obesity-related kidney disease is characterized by glomerulomegaly, which is often accompanied by localized and segmental glomerulosclerosis lesions. In these patients, the early symptoms are atypical, with microproteinuria being the main clinical manifestation and nephrotic syndrome being rare. Weight loss and RAAS blockers have a protective effect on obesity-related CKD, but even so, a significant proportion of patients eventually progress to end-stage renal disease despite treatment. Thus, it is critical to comprehend the mechanisms underlying obesity-related CKD to create new tactics for slowing or stopping disease progression. In this review, we summarize current knowledge on the mechanisms of obesity-related kidney disease, its pathological changes, and future perspectives on its treatment.
C1 [Jiang, Zongmiao; Zhao, Xue; Cui, Haiying; Han, Mingyue; Ren, Xinhua; Gang, Xiaokun; Wang, Guixia] First Hosp Jilin Univ, Dept Endocrinol & Metab, Changchun, Peoples R China.
   [Wang, Yao] Second Hosp Jilin Univ, Dept Orthoped, Changchun, Peoples R China.
C3 Jilin University; Jilin University
RP Gang, XK; Wang, GX (corresponding author), First Hosp Jilin Univ, Dept Endocrinol & Metab, Changchun, Peoples R China.
EM gangxk@jlu.edu.cn; gwang168@jlu.edu.cn
RI Mingyue, Han/GPS-9055-2022
OI Cui, Haiying/0000-0002-2558-4538
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NR 225
TC 65
Z9 69
U1 5
U2 22
PU AMER PHYSIOLOGICAL SOC
PI Rockville
PA 6120 Executive Blvd, Suite 600, Rockville, MD, UNITED STATES
SN 0193-1849
EI 1522-1555
J9 AM J PHYSIOL-ENDOC M
JI Am. J. Physiol.-Endocrinol. Metab.
PD JAN
PY 2022
VL 324
IS 1
BP E24
EP E41
DI 10.1152/ajpendo.00179.2022
PG 18
WC Endocrinology & Metabolism; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Physiology
GA 8E6VA
UT WOS:000919107100003
PM 36383637
DA 2025-06-11
ER

PT J
AU Valenti, L
   Riso, P
   Mazzocchi, A
   Porrini, M
   Fargion, S
   Agostoni, C
AF Valenti, Luca
   Riso, Patrizia
   Mazzocchi, Alessandra
   Porrini, Marisa
   Fargion, Silvia
   Agostoni, Carlo
TI Dietary Anthocyanins as Nutritional Therapy for Nonalcoholic Fatty Liver
   Disease
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Review
ID ACTIVATED PROTEIN-KINASE; HEPATIC STEATOSIS; INSULIN-RESISTANCE;
   AMELIORATES HYPERGLYCEMIA; LIPID-ACCUMULATION; OXIDATIVE STRESS;
   ADIPOSE-TISSUE; UNITED-STATES; RISK-FACTORS; OBESE MEN
AB Nonalcoholic fatty liver disease (NAFLD), defined by excessive lipid accumulation in the liver, is the hepatic manifestation of insulin resistance and the metabolic syndrome. Due to the epidemics of obesity, NAFLD is rapidly becoming the leading cause of altered liver enzymes in Western countries. NAFLD encompasses a wide spectrum of liver disease ranging from simple uncomplicated steatosis, to steatohepatitis, cirrhosis, and hepatocellular carcinoma. Diet may affect the development of NAFLD either by increasing risk or by providing protective factors. Therefore, it is important to investigate the role of foods and/or food bioactives on the metabolic processes involved in steatohepatitis for preventive strategies. It has been reported that anthocyanins (ACNs) decrease hepatic lipid accumulation and may counteract oxidative stress and hepatic inflammation, but their impact on NAFLD has yet to be fully determined. ACNs are water-soluble bioactive compounds of the polyphenol class present in many vegetable products. Here, we summarize the evidence evaluating the mechanisms of action of ACNs on hepatic lipid metabolism in different experimental setting: in vitro, in vivo, and in human trials. Finally, a working model depicting the possible mechanisms underpinning the beneficial effects of ACNs in NAFLD is proposed, based on the available literature.
C1 [Valenti, Luca; Fargion, Silvia] Univ Milan, Dept Pathophysiol & Transplantat DEPT, Fdn IRCCS, Ca Granda Osped Policlin, I-20122 Milan, Italy.
   [Riso, Patrizia; Porrini, Marisa] Univ Milan, Div Human Nutr, Dept Food Environm & Nutr Sci DeFENS, I-20122 Milan, Italy.
   [Mazzocchi, Alessandra; Agostoni, Carlo] Univ Milan, Pediat Clin 2, Dept Clin Sci & Community Hlth, Fdn IRCCS,Ca Granda Osped Policlin, I-20122 Milan, Italy.
C3 University of Milan; IRCCS Ca Granda Ospedale Maggiore Policlinico;
   University of Milan; University of Milan; IRCCS Ca Granda Ospedale
   Maggiore Policlinico
RP Valenti, L (corresponding author), Univ Milan, Dept Pathophysiol & Transplantat DEPT, Fdn IRCCS, Ca Granda Osped Policlin, I-20122 Milan, Italy.
EM luca.valenti@unimi.it
RI Agostoni, Carlo/A-9303-2012; Riso, Patrizia/AAC-2072-2019; porrini,
   marisa/AAF-6788-2021; Valenti, Luca/B-3695-2009; Agostoni,
   Carlo/B-3470-2015
OI Valenti, Luca/0000-0001-8909-0345; Mazzocchi,
   Alessandra/0000-0003-0291-2874; Agostoni, Carlo/0000-0002-5006-0832;
   Riso, Patrizia/0000-0002-9204-7257; porrini, marisa/0000-0003-2693-3311
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NR 67
TC 99
Z9 106
U1 2
U2 44
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PY 2013
VL 2013
AR 145421
DI 10.1155/2013/145421
PG 8
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA 246II
UT WOS:000326531000001
PM 24282628
OA Green Published, Green Submitted, hybrid
DA 2025-06-11
ER

PT J
AU Wu, Y
   Jin, XS
   Zhang, Y
   Liu, J
   Wu, MJ
   Tong, HB
AF Wu, Yu
   Jin, Xiaosheng
   Zhang, Ya
   Liu, Jian
   Wu, Mingjiang
   Tong, Haibin
TI Bioactive Compounds from Brown Algae Alleviate Nonalcoholic Fatty Liver
   Disease: An Extensive Review
SO JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
LA English
DT Review; Early Access
DE brown algae; polysaccharides; phlorotannins; fucoxanthin; NAFLD
ID ECKLONIA-CAVA; LAMINARIA-JAPONICA; METABOLIC SYNDROME; OXIDATIVE STRESS;
   CARDIOVASCULAR-DISEASE; APPETITE REGULATION; HEPATIC STEATOSIS;
   LIPID-METABOLISM; DOWN-REGULATION; FUCOXANTHIN
AB Nonalcoholic fatty liver disease (NAFLD) is one of the most prevalent chronic liver diseases. The increasing NAFLD incidences are associated with unhealthy lifestyles. Currently, there are no effective therapeutic options for NAFLD. Thus, there is a need to develop safe, efficient, and economic treatment options for NAFLD. Brown algae, which are edible, contain abundant bioactive compounds, including polysaccharides and phlorotannins. They have been shown to ameliorate insulin resistance, as well as hepatic steatosis, and all of these biological functions can potentially alleviate NAFLD. Accumulating reports have shown that increasing dietary consumption of brown algae reduces the risk for NAFLD development. In this review, we summarized the animal experiments and clinical proof of brown algae and their bioactive compounds for NAFLD treatment within the past decade. Our findings show possible avenues for further research into the pathophysiology of NAFLD and brown algae therapy.
C1 [Wu, Yu; Zhang, Ya; Liu, Jian; Wu, Mingjiang; Tong, Haibin] Wenzhou Univ, Coll Life & Environm Sci, Zhejiang Prov Key Lab Water Environm & Marine Biol, Wenzhou 325000, Peoples R China.
   [Jin, Xiaosheng] Wenzhou Med Univ, Dept Gastroenterol, Affiliated Hosp 3, Wenzhou 325000, Peoples R China.
C3 Wenzhou University; Wenzhou Medical University
RP Wu, MJ; Tong, HB (corresponding author), Wenzhou Univ, Coll Life & Environm Sci, Zhejiang Prov Key Lab Water Environm & Marine Biol, Wenzhou 325000, Peoples R China.
EM wmj@wzu.edu.cn; tonghaibin@gmail.com
RI zhang, ya/KJL-6126-2024; Wu, MJ/KQV-3644-2024
OI Tong, Haibin/0000-0002-7645-3458
FU National Natural Science Foundation of China [81872952, 41876197];
   Science and Technology Program of Wenzhou [ZY2019013, ZN2022009];
   Science and Technology Program of Ruian [MS2021008]
FX This work was financially supported by the National Natural Science
   Foundation of China (81872952 and 41876197) , the Science and Technology
   Program of Wenzhou (ZY2019013 and ZN2022009) and the Science and
   Technology Program of Ruian (MS2021008) .
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NR 130
TC 16
Z9 16
U1 12
U2 56
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0021-8561
EI 1520-5118
J9 J AGR FOOD CHEM
JI J. Agric. Food Chem.
PD 2023 JAN 23
PY 2023
DI 10.1021/acs.jafc.2c06578
EA JAN 2023
PG 17
WC Agriculture, Multidisciplinary; Chemistry, Applied; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture; Chemistry; Food Science & Technology
GA 8M4IF
UT WOS:000924430100001
PM 36689477
DA 2025-06-11
ER

PT J
AU Shan, ZG
   Nisar, MF
   Li, MX
   Zhang, CH
   Wan, CP
AF Shan, Zhiguo
   Nisar, Muhammad Farrukh
   Li, Mingxi
   Zhang, Chunhua
   Wan, Chunpeng (Craig)
TI RETRACTED: Theaflavin Chemistry and Its Health Benefits (Retracted
   Article)
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Review; Retracted Publication
ID BLACK TEA THEAFLAVINS; NF-KAPPA-B; GREEN TEA; OXIDATIVE STRESS;
   IN-VITRO; (-)-EPIGALLOCATECHIN GALLATE; REPERFUSION INJURY; METABOLIC
   SYNDROME; PLASMA KALLIKREIN; DNA-DAMAGE
AB Huge epidemiological and clinical studies have confirmed that black tea is a rich source of health-promoting ingredients, such as catechins and theaflavins (TFs). Furthermore, TF derivatives mainly include theaflavin (TF1), theaflavin-3-gallate (TF2A), theaflavin-3 '-gallate (TF2B), and theaflavin-3,3 '-digallate (TF3). All of these TFs exhibit extensive usages in pharmaceutics, foods, and traditional medication systems. Various indepth studies reported that how TFs modulates health effects in cellular and molecular mechanisms. The available literature regarding the pharmacological activities of TFs has revealed that TF3 has remarkable anti-inflammatory, antioxidant, anticancer, antiobesity, antiosteoporotic, and antimicrobial properties, thus posing significant effects on human health. The current manuscript summarizes both the chemistry and various pharmacological effects of TFs on human health, lifestyle or aging associated diseases, and populations of gut microbiota. Furthermore, the biological potential of TFs has also been focused to provide a deeper understanding of its mechanism of action.
C1 [Shan, Zhiguo; Zhang, Chunhua] Puer Univ, Coll Agr & Forestry, Puer 665099, Peoples R China.
   [Nisar, Muhammad Farrukh; Wan, Chunpeng (Craig)] Jiangxi Agr Univ, Coll Agron, Jiangxi Key Lab Postharvest Technol & Nondestruct, Nanchang 330045, Jiangxi, Peoples R China.
   [Nisar, Muhammad Farrukh] Cholistan Univ Vet & Anim Sci CUVAS, Dept Physiol & Biochem, Bahawalpur 63100, Pakistan.
   [Li, Mingxi] Jiangxi Agr Univ, Coll Agron, Res Ctr Tea & Tea Culture, Nanchang, Jiangxi, Peoples R China.
C3 Pu'er University; Jiangxi Agricultural University; Jiangxi Agricultural
   University
RP Zhang, CH (corresponding author), Puer Univ, Coll Agr & Forestry, Puer 665099, Peoples R China.; Wan, CP (corresponding author), Jiangxi Agr Univ, Coll Agron, Jiangxi Key Lab Postharvest Technol & Nondestruct, Nanchang 330045, Jiangxi, Peoples R China.
EM puercha517@163.com; mfarrukhnisar@cuvas.edu.pk; li13699529617@163.com;
   puercha510@163.com; chunpengwan@jxau.edu.cn
RI wan, chunpeng/T-8707-2019; Li, Yong-Qiang/E-4298-2019; Zhang,
   Chunhua/ISB-1530-2023; Wan, Chunpeng/H-1423-2011; NISAR, MUHAMMAD
   FARRUKH/GQQ-8386-2022
OI Wan, Chunpeng/0000-0001-6892-016X; NISAR, MUHAMMAD
   FARRUKH/0000-0001-8873-1227
FU Natural Science Foundation of China [32160725]; Pu'er tea processing
   engineering research center in Yunnan Province University, Pu'er College
   High-level Talents Research Initiation Project [K2015032]; Yunnan
   Provincial Education Department Science Research Fund Project
   [2018JS513, K2017058]; Pu'er College Key Project [K2018012]; Young
   Academic and Technical Leaders Reserve Talent Training Program of Pu'er
   College [QNRC20-02]; Young Backbone Teacher Training Project of Pu'er
   College [2020GGJS005]; Special Planning Project for Key Scientific
   Research of Pu'er College [2020XJGH08]
FX This research was funded by the Natural Science Foundation of China (No.
   32160725), Pu'er tea processing engineering research center in Yunnan
   Province University, Pu'er College High-level Talents Research
   Initiation Project (K2015032), Yunnan Provincial Education Department
   Science Research Fund Project (2018JS513, K2017058), Pu'er College Key
   Project (K2018012), Young Academic and Technical Leaders Reserve Talent
   Training Program of Pu'er College (QNRC20-02), Young Backbone Teacher
   Training Project of Pu'er College (2020GGJS005), and Special Planning
   Project for Key Scientific Research of Pu'er College (2020XJGH08).
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NR 160
TC 56
Z9 63
U1 4
U2 124
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PD NOV 18
PY 2021
VL 2021
AR 6256618
DI 10.1155/2021/6256618
PG 16
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA XL3RI
UT WOS:000728063800001
PM 34804369
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Adesunloye, BA
AF Adesunloye, Bamidele A.
TI Mechanistic Insights into the Link between Obesity and Prostate Cancer
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE obesity; prostate cancer; adipose tissue; chronic inflammation;
   cytokines; adipokines; insulin-like growth factor
ID TUMOR-NECROSIS-FACTOR; EPITHELIAL-MESENCHYMAL TRANSITION; ENDOTHELIAL
   GROWTH-FACTOR; INDUCIBLE FACTOR 1-ALPHA; WHITE ADIPOSE-TISSUE;
   TNF-ALPHA; LEPTIN CONCENTRATIONS; METABOLIC SYNDROME; STROMAL CELLS;
   FACTOR-I
AB Obesity is a pandemic of increasing worldwide prevalence. There is evidence of an association between obesity and the risk of prostate cancer from observational studies, and different biologic mechanisms have been proposed. The chronic low-level inflammation within the adipose tissue in obesity results in oxidative stress, activation of inflammatory cytokines, deregulation of adipokines signaling, and increased circulating levels of insulin and insulin-like growth factors (IGF). These mechanisms may be involved in epithelial to mesenchymal transformation into a malignant phenotype that promotes invasiveness, aggressiveness, and metastatic potential of prostate cancer. A thorough understanding of these mechanisms may be valuable in the development of effective prostate cancer prevention strategies and treatments. This review provides an overview of these mechanisms.
C1 [Adesunloye, Bamidele A.] Canc Treatment Ctr Amer, 600 Celebrate Life Pkwy, Newnan, GA 30265 USA.
RP Adesunloye, BA (corresponding author), Canc Treatment Ctr Amer, 600 Celebrate Life Pkwy, Newnan, GA 30265 USA.
EM bamidele.adesunloye@ctca-hope.com
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NR 93
TC 19
Z9 22
U1 0
U2 6
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD APR
PY 2021
VL 22
IS 8
AR 3935
DI 10.3390/ijms22083935
PG 13
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA RT3AQ
UT WOS:000644335400001
PM 33920379
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Martins, AC
   Santos, AAD
   Lopes, ACBA
   Skalny, AV
   Aschner, M
   Tinkov, AA
   Paoliello, MMB
AF Martins, Airton C.
   Santos, Alessanda A. D.
   Lopes, Ana C. B. A.
   Skalny, Anatoly, V
   Aschner, Michael
   Tinkov, Alexey A.
   Paoliello, Monica M. B.
TI Endothelial Dysfunction Induced by Cadmium and Mercury and its
   Relationship to Hypertension
SO CURRENT HYPERTENSION REVIEWS
LA English
DT Review
DE Cadmium; mercury; heavy metals; nitric oxide; hypertension; endothelial
   dysfunction
ID SYSTOLIC BLOOD-PRESSURE; KOREAN NATIONAL-HEALTH; SMOOTH-MUSCLE-CELLS;
   OXIDATIVE STRESS; NITRIC-OXIDE; ANGIOTENSIN-II; METABOLIC SYNDROME;
   INORGANIC MERCURY; VASCULAR DYSFUNCTION; CARDIOVASCULAR RISK
AB Hypertension is an important public health concern that affects millions globally, leading to a large number of morbidities and fatalities. The etiology of hypertension is complex and multifactorial, and it involves environmental factors, including heavy metals. Cadmium and mercury are toxic elements commonly found in the environment, contributing to hypertension. We aimed to assess the role of cadmium and mercury-induced endothelial dysfunction in the development of hypertension. A narrative review was carried out through database searches. In this review, we discussed the critical roles of cadmium and mercury in the etiology of hypertension and provided new insights into potential mechanisms of their effect, focusing primarily on endothelial dysfunction. Although the mechanisms by which cadmium and mercury induce hypertension have yet to be completely elucidated, evidence for both implicates impaired nitric oxide signaling in their hypertensive etiology.
C1 [Martins, Airton C.; Santos, Alessanda A. D.; Aschner, Michael; Paoliello, Monica M. B.] Albert Einstein Coll Med, Dept Mol Pharmacol, Forchheimer 209,1300 Morris Pk Ave, Bronx, NY 10461 USA.
   [Lopes, Ana C. B. A.; Paoliello, Monica M. B.] Univ Estadual Londrina, Ctr Hlth Sci, Grad Program Publ Hlth, Londrina, Parana, Brazil.
   [Skalny, Anatoly, V; Aschner, Michael; Tinkov, Alexey A.] Sechenov Univ, Med Elementol, IM Sechenov Moscow State Med Univ 1, Moscow, Russia.
   [Skalny, Anatoly, V] Russian Acad Sci, Fed Res Ctr Biol Syst & Agrotechnol, Orenburg, Russia.
   [Skalny, Anatoly, V; Tinkov, Alexey A.] Yaroslavl State Univ, Yaroslavl 150000, Russia.
C3 Montefiore Medical Center; Albert Einstein College of Medicine; Yeshiva
   University; Universidade Estadual de Londrina; Sechenov First Moscow
   State Medical University; Russian Academy of Sciences; Federal Research
   Centre of Biological Systems & Agro-technologies of the Russian Academy
   of Sciences; Yaroslavl State University
RP Paoliello, MMB (corresponding author), Albert Einstein Coll Med, Dept Mol Pharmacol, Forchheimer 209,1300 Morris Pk Ave, Bronx, NY 10461 USA.
EM monica.paoliello@einsteinmed.org
RI Martins, Airton/I-8463-2017; Venancio Lopes, Ana Carolina/AAX-4000-2021;
   Aschner, Michael/ACO-6461-2022; Skalny, Anatoly/J-3953-2019; Tinkov,
   Alexey/H-5842-2016
OI paoliello, monica/0000-0002-1898-6133
FU Albert Einstein College of Medicine, Yeshiva University; National
   Institute of Environmental Health Sciences (NIEHS) [R01ES10563,
   R01ES07331]
FX MA was supported in parts by the grants from Albert Einstein College of
   Medicine, Yeshiva University, and the National Institute of
   Environmental Health Sciences (NIEHS) R01ES10563 and R01ES07331.
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NR 163
TC 17
Z9 19
U1 2
U2 23
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1573-4021
EI 1875-6506
J9 CURR HYPERTENS REV
JI Curr. Hypertens. Rev.
PY 2021
VL 17
IS 1
BP 14
EP 26
DI 10.2174/1573402117666210121102405
PG 13
WC Peripheral Vascular Disease
WE Emerging Sources Citation Index (ESCI)
SC Cardiovascular System & Cardiology
GA SL2FK
UT WOS:000656735600004
PM 33475076
DA 2025-06-11
ER

PT J
AU Lindstad, T
   Qu, S
   Sikkeland, J
   Jin, Y
   Kristian, A
   Mælandsmo, GM
   Collas, P
   Saatcioglu, F
AF Lindstad, Torstein
   Qu, Su
   Sikkeland, Jorgen
   Jin, Yang
   Kristian, Alexandr
   Maelandsmo, Gunhild M.
   Collas, Philippe
   Saatcioglu, Fahri
TI STAMP2 is required for human adipose-derived stem cell differentiation
   and adipocyte-facilitated prostate cancer growth in vivo
SO ONCOTARGET
LA English
DT Article
DE STAMP2; ASC; lipogenesis; adipogenesis; prostate cancer
ID 6-TRANSMEMBRANE EPITHELIAL ANTIGEN; NECROSIS-FACTOR-ALPHA; BODY-MASS
   INDEX; POSITIVE REGULATOR; METABOLIC SYNDROME; 3T3-L1 ADIPOCYTES;
   OXIDATIVE STRESS; TUMOR-GROWTH; OBESITY; TISSUE
AB Six Transmembrane Protein of Prostate 2 (STAMP2) has been implicated in both prostate cancer (PCa) and metabolic disease. STAMP2 has unique anti-inflammatory and pro-metabolic properties in mouse adipose tissue, but there is limited information on its role in human metabolic tissues. Using human adipose-derived stem cells (ASCs), we report that STAMP2 expression is dramatically upregulated during adipogenesis. shRNA-mediated STAMP2 knockdown in ASCs significantly suppresses adipogenesis and interferes with optimal expression of adipogenic genes and adipocyte metabolic function. Furthermore, ASC-derived adipocyte-mediated stimulation of prostate tumor growth in nude mice is significantly reduced upon STAMP2 knockdown in ASC adipocytes. These results suggest that STAMP2 is crucial for normal ASC conversion into adipocytes and their metabolic function, as well as their ability to facilitate PCa growth in vivo.
C1 [Lindstad, Torstein; Qu, Su; Sikkeland, Jorgen; Jin, Yang; Saatcioglu, Fahri] Univ Oslo, Dept Biosci, Oslo, Norway.
   [Sikkeland, Jorgen; Jin, Yang; Saatcioglu, Fahri] Oslo Univ Hosp, Dept Canc Genet & Informat, Oslo, Norway.
   [Kristian, Alexandr; Maelandsmo, Gunhild M.] Oslo Univ Hosp, Inst Canc Res, Dept Tumor Biol, Oslo, Norway.
   [Collas, Philippe] Univ Oslo, Norwegian Ctr Stem Cell Res, Inst Basic Med Sci, Oslo, Norway.
C3 University of Oslo; University of Oslo; University of Oslo; University
   of Oslo
RP Saatcioglu, F (corresponding author), Univ Oslo, Dept Biosci, Oslo, Norway.; Saatcioglu, F (corresponding author), Oslo Univ Hosp, Dept Canc Genet & Informat, Oslo, Norway.
EM fahris@ibv.uio.no
RI Collas, Philippe/IRZ-5918-2023; Mælandsmo, Gunhild Mari/AFV-4446-2022;
   Jin, Yang/GXF-7896-2022
OI Jin, Yang/0000-0002-7996-048X; Maelandsmo, Gunhild
   Mari/0000-0002-4797-1600
FU Norwegian Research Council [193337]; Norwegian Cancer Society [419204];
   South-Eastern Norway Regional Health Authority [2012070]
FX This work was supported by grants from the Norwegian Research Council
   (grant 193337), Norwegian Cancer Society (grant 419204), and
   South-Eastern Norway Regional Health Authority (grant 2012070).
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NR 63
TC 6
Z9 7
U1 0
U2 4
PU IMPACT JOURNALS LLC
PI ORCHARD PARK
PA 6666 E QUAKER ST, STE 1, ORCHARD PARK, NY 14127 USA
EI 1949-2553
J9 ONCOTARGET
JI Oncotarget
PD NOV 3
PY 2017
VL 8
IS 54
BP 91817
EP 91827
DI 10.18632/oncotarget.11131
PG 11
WC Oncology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Cell Biology
GA FL9VD
UT WOS:000414606800001
PM 29190878
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU de Oliveira, ARS
   Cruz, KJC
   Severo, JS
   Morais, JBS
   de Freitas, TEC
   Araújo, RS
   Marreiro, DD
AF Soares de Oliveira, Ana Raquel
   Climaco Cruz, Kyria Jayanne
   Severo, Juliana Soares
   Silva Morais, Jennifer Beatriz
   Coelho de Freitas, Taynah Emannuelle
   Araujo, Rogerio Santiago
   Marreiro, Dilina do Nascimento
TI Hypomagnesemia and its relation with chronic low-grade inflammation in
   obesity
SO REVISTA DA ASSOCIACAO MEDICA BRASILEIRA
LA English
DT Review
DE obesity; magnesium; low-grade inflammation
ID ORAL MAGNESIUM SUPPLEMENTATION; C-REACTIVE PROTEIN; BODY-MASS INDEX;
   INSULIN-RESISTANCE; SERUM MAGNESIUM; METABOLIC SYNDROME; ENDOTHELIAL
   DYSFUNCTION; ADIPOSE-TISSUE; CALCIUM; STRESS
AB Introduction: The accumulation of visceral fat in obesity is associated with excessive production of proinflammatory adipokines, which contributes to low- grade chronic inflammation state. Moreover, the literature has shown that mineral deficiency, in particular of magnesium, has important role in the pathogenesis of this metabolic disorder with relevant clinical repercussions.
   Objective: To bring updated information about the participation of hypomagnesemia in the manifestation of low-grade chronic inflammation in obese individuals.
   Method: Articles published in PubMed, SciELO, LILACS and ScienceDirect, using the following keywords: "obesity,""magnesium"and "low grade inflammation."
   Results: Scientific evidence suggests that magnesium deficiency favors the manifestation of low-grade chronic inflammation in obese subjects.
   Conclusion: From literature data, it is evident the participation of magnesium through biochemical and metabolic reactions in protecting against this metabolic disorder present in obesity.
C1 [Soares de Oliveira, Ana Raquel; Climaco Cruz, Kyria Jayanne; Severo, Juliana Soares; Silva Morais, Jennifer Beatriz] Univ Fed Piau UFPI, Food & Nutr, Teresina, PI, Brazil.
   [Coelho de Freitas, Taynah Emannuelle] Univ Fed Piaui, Teresina, PI, Brazil.
   [Araujo, Rogerio Santiago] Univ Fed Piaui, Dept Gen Practice, Teresina, PI, Brazil.
   [Marreiro, Dilina do Nascimento] Univ Fed Piaui, Dept Nutr, Teresina, PI, Brazil.
C3 Universidade Federal do Piaui; Universidade Federal do Piaui;
   Universidade Federal do Piaui; Universidade Federal do Piaui
RP Marreiro, DD (corresponding author), Rua Hugo Napoleao 665,Ed Pl Reale Apto 2001, BR-64048320 Teresina, PI, Brazil.
EM dilina.marreiro@gmail.com
RI ARAUJO, ROGERIO/HGC-5473-2022; CRUZ, KYRIA/LOQ-9371-2024; Severo,
   Juliana/C-5152-2018
OI Cruz, Kyria Jayanne/0000-0002-4489-702X; Severo,
   Juliana/0000-0002-1771-7871
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NR 60
TC 24
Z9 26
U1 0
U2 4
PU ASSOC MEDICA BRASILEIRA
PI SAO PAULO
PA RUA SAO CARLOS DO PINHAL 324, CAIXA POSTAL 8904, SAO PAULO, SP, BRAZIL
EI 1806-9282
J9 REV ASSOC MED BRAS
JI Rev. Assoc. Med. Bras.
PD FEB
PY 2017
VL 63
IS 2
BP 156
EP 163
DI 10.1590/1806-9282.63.02.156
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA EQ2CH
UT WOS:000397875400011
PM 28355377
OA gold, Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Grodnitskaya, EE
   Kurtser, MA
AF Grodnitskaya, Elena E.
   Kurtser, Mark A.
TI Homocysteine metabolism in polycystic ovary syndrome
SO GYNECOLOGICAL ENDOCRINOLOGY
LA English
DT Article
DE Homocysteine; folate; methylenetetrahydrofolate reductase; insulin
   resistance; endothelial dysfunction; polycystic ovary syndrome
ID PLASMA TOTAL HOMOCYSTEINE; INSULIN-RESISTANCE; CARDIOVASCULAR RISK;
   SERUM CONCENTRATIONS; ENDOTHELIAL FUNCTION; YOUNG-WOMEN; METFORMIN;
   FOLATE; ROSIGLITAZONE; SUPPLEMENTATION
AB Homocysteine, a sulfur-containing amino acid formed during the metabolism of methionine, exert cytotoxic effects on vascular endothelium. Molecular mechanisms of homocysteine-induced cellular dysfunction include increased inflammatory cytokine expression, altered nitric oxide bioavailability, induction of oxidative stress, activation of apoptosis and defective methylation. Hyperhomocysteinemia is associated with an increased risk of atherosclerotic and thromboembolic disorders, as well as hyperinsulinemia and may partially account for increased risk of cardiovascular disease associated with insulin resistance. Women with PCOS are more likely to develop components of the metabolic syndrome such as disturbances of carbohydrate metabolism, obesity, hypertension and dyslipidemia, which in turn are risk factors for cardiovascular disease. A number of studies confirmed the presence of increased serum homocysteine concentration in PCOS patients and the possible determinants of this observation are still debated. PCOS treatment options can influence homocysteine levels.
C1 [Grodnitskaya, Elena E.; Kurtser, Mark A.] Moscow Ctr Family Planning & Reprod, Moscow, Russia.
RP Grodnitskaya, EE (corresponding author), Klenoviy Bulvar 10-1-162, Moscow 115470, Russia.
EM elena1778@mail.ru
RI Kurtser, Mark/AAD-9432-2021
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NR 48
TC 26
Z9 28
U1 0
U2 7
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0951-3590
EI 1473-0766
J9 GYNECOL ENDOCRINOL
JI Gynecol. Endocrinol.
PD MAR
PY 2012
VL 28
IS 3
BP 186
EP 189
DI 10.3109/09513590.2011.589927
PG 4
WC Endocrinology & Metabolism; Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Obstetrics & Gynecology
GA 894OQ
UT WOS:000300436700007
PM 21793705
DA 2025-06-11
ER

PT J
AU Lefranc, C
   Friederich-Persson, M
   Foufelle, F
   Cat, AND
   Jaisser, F
AF Lefranc, Clara
   Friederich-Persson, Malou
   Foufelle, Fabienne
   Nguyen Dinh Cat, Aurelie
   Jaisser, Frederic
TI Adipocyte-Mineralocorticoid Receptor Alters Mitochondrial Quality
   Control Leading to Mitochondrial Dysfunction and Senescence of Visceral
   Adipose Tissue
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE mineralocorticoid receptor; mitochondrial dysfunction; adipose tissue;
   oxidative stress; senescence; metabolic syndrome
AB Mineralocorticoid receptor (MR) expression is increased in the adipose tissue (AT) of obese patients and animals. We previously demonstrated that adipocyte-MR overexpression in mice (Adipo-MROE mice) is associated with metabolic alterations. Moreover, we showed that MR regulates mitochondrial dysfunction and cellular senescence in the visceral AT of obese db/db mice. Our hypothesis is that adipocyte-MR overactivation triggers mitochondrial dysfunction and cellular senescence, through increased mitochondrial oxidative stress (OS). Using the Adipo-MROE mice with conditional adipocyte-MR expression, we evaluated the specific effects of adipocyte-MR on global and mitochondrial OS, as well as on OS-induced damage. Mitochondrial function was assessed by high throughput respirometry. Molecular mechanisms were probed in AT focusing on mitochondrial quality control and senescence markers. Adipo-MROE mice exhibited increased mitochondrial OS and altered mitochondrial respiration, associated with reduced biogenesis and increased fission. This was associated with OS-induced DNA-damage and AT premature senescence. In conclusion, targeted adipocyte-MR overexpression leads to an imbalance in mitochondrial dynamics and regeneration, to mitochondrial dysfunction and to ageing in visceral AT. These data bring new insights into the MR-dependent AT dysfunction in obesity.
C1 [Lefranc, Clara; Foufelle, Fabienne; Nguyen Dinh Cat, Aurelie; Jaisser, Frederic] Univ Paris, Sorbonne Univ, INSERM, Ctr Rech Cordeliers,Team Metab Dis Diabet & Comor, F-75006 Paris, France.
   [Friederich-Persson, Malou] Uppsala Univ, Dept Med Cell Biol, S-75123 Uppsala, Sweden.
   [Jaisser, Frederic] CHRU Nancy, INSERM, French Clin Res Infrastruct Network FCRIN INI CRC, UMR 1116,Ctr Invest Clin Plurithemat 1433, F-54500 Vandoeuvre Les Nancy, France.
C3 Universite Paris Cite; Institut National de la Sante et de la Recherche
   Medicale (Inserm); Sorbonne Universite; Uppsala University; Institut
   National de la Sante et de la Recherche Medicale (Inserm); Universite de
   Lorraine; CHU de Nancy
RP Jaisser, F (corresponding author), Univ Paris, Sorbonne Univ, INSERM, Ctr Rech Cordeliers,Team Metab Dis Diabet & Comor, F-75006 Paris, France.; Jaisser, F (corresponding author), CHRU Nancy, INSERM, French Clin Res Infrastruct Network FCRIN INI CRC, UMR 1116,Ctr Invest Clin Plurithemat 1433, F-54500 Vandoeuvre Les Nancy, France.
EM clara.lefranc@gmail.com; malou.friederich@mcb.uu.se;
   fabienne.foufelle@inserm.fr; cattuong.ndc@gmail.com;
   frederic.jaisser@inserm.fr
OI Lefranc, Clara/0000-0003-4635-136X; Nguyen Dinh Cat,
   Aurelie/0000-0002-3007-5332
FU INSERM; CARMMA Avenir investment program [ANR-15-RHUS-0003]; Fondation
   de France [CARDIO 00086498]; INSERM Poste d'Accueil fellowship;
   Wenner-Gren Foundations; Magnus Bergvall Foundation; AkeWiberg
   Foundation
FX This work was supported by grants from INSERM, the CARMMA Avenir
   investment program (ANR-15-RHUS-0003) and the Fondation de France
   (CARDIO 00086498). C.L. is supported by an INSERM Poste d'Accueil
   fellowship. M.F.-P. is supported by funding from the Wenner-Gren
   Foundations, the Magnus Bergvall Foundation and the AkeWiberg
   Foundation.
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NR 75
TC 12
Z9 12
U1 1
U2 5
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD MAR
PY 2021
VL 22
IS 6
AR 2881
DI 10.3390/ijms22062881
PG 16
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA RV4ID
UT WOS:000645797600001
PM 33809055
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Lee, YY
   Choo, OS
   Kim, YJ
   Gil, ES
   Jang, JH
   Kang, Y
   Choung, YH
AF Lee, Yun Yeong
   Choo, Oak-sung
   Kim, Yeon Ju
   Gil, Eun Sol
   Jang, Jeong Hun
   Kang, Yup
   Choung, Yun-Hoon
TI Atorvastatin prevents hearing impairment in the presence of
   hyperlipidemia
SO BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
LA English
DT Article
DE Atorvastatin; Hyperlipidemia; Hearing impairment; pAKT; ROS; Apoptosis
ID GLYCOGEN-SYNTHASE KINASE-3; HIGH-FAT DIET; METABOLIC SYNDROME;
   INNER-EAR; OXIDATIVE STRESS; CELL-SURVIVAL; HIGH-FRUCTOSE; AGE;
   ASSOCIATION; AKT
AB It is known that hyperlipidemia is a risk factor for sensorineural hearing loss. However, the biological mechanisms underlying hyperlipidemia and hearing impairment have not been completely elucidated in the cochlea. Based on our previous study of human subjects, elderly people taking drugs for hyperlipidemia showed better hearing than those not taking any medications. We hypothesized that drugs for hyperlipidemia, such as statins, may have the potential to prevent hearing impairment. The aim of this study was to investigate the correlation between hyperlipidemia and hearing impairment and the hearing preservation effect of atorvastatin using a hyperlipidemic mouse model with diet-induced obesity (DIO). Here, we demonstrate that DIO mice had a significant hearing impairment as well as increased levels of reactive oxygen species (ROS) and hair cell death due to reduced levels of pAKT and superoxide dismutase 2 (SOD2). However, these changes were significantly prevented by atorvastatin. Oxidative stress-induced intrinsic apoptosis was decreased by the high expression of Nrf2 and antioxidant genes, which improved mitochondrial function and ROS via activation of the PI3K-pAKT pathway by atorvastatin. Therefore, atorvastatin has the potential to prevent hearing impairment via redox balance in the presence of hyperlipidemia.
C1 [Lee, Yun Yeong; Choo, Oak-sung; Kim, Yeon Ju; Gil, Eun Sol; Jang, Jeong Hun; Kang, Yup; Choung, Yun-Hoon] Ajou Univ, Dept Otolaryngol, Sch Med, Suwon 443749, Gyunggi Do, South Korea.
   [Gil, Eun Sol; Choung, Yun-Hoon] Ajou Univ, Dept Biomed Sci, Grad Sch Med, Suwon 443749, Gyunggi Do, South Korea.
   [Kang, Yup] Ajou Univ, Dept Physiol, Sch Med, Suwon 443749, Gyunggi Do, South Korea.
C3 Ajou University; Ajou University; Ajou University
RP Kang, Y (corresponding author), Ajou Univ, Dept Physiol, Sch Med, Suwon 443749, Gyunggi Do, South Korea.; Choung, YH (corresponding author), Ajou Univ, Dept Otolaryngol, Sch Med, 164 World Cup Ro, Suwon 443380, Gyeonggi Do, South Korea.
EM kangy@ajou.ac.kr; yhc@ajou.ac.kr
RI Kim, Jangho/ADD-2287-2022
OI Choung, Yun-Hoon/0000-0002-0786-1781
FU National Research Foundation (NRF) grant - Korean government (MSIP)
   [NRF-2019R1A2C2002384, NRF-2019M3A9H1103737]
FX This work was supported by a National Research Foundation (NRF) grant
   (No. NRF-2019R1A2C2002384 and No. NRF-2019M3A9H1103737) funded by the
   Korean government (MSIP).
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NR 55
TC 21
Z9 24
U1 1
U2 19
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0167-4889
EI 1879-2596
J9 BBA-MOL CELL RES
JI Biochim. Biophys. Acta-Mol. Cell Res.
PD DEC
PY 2020
VL 1867
IS 12
AR 118850
DI 10.1016/j.bbamcr.2020.118850
PG 13
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA NY1DB
UT WOS:000576137700015
PM 32918982
DA 2025-06-11
ER

PT J
AU Ferreira, MA
   Silva, DM
   de Morais, AC
   Mota, JF
   Botelho, PB
AF Ferreira, M. A.
   Silva, D. M.
   de Morais, A. C., Jr.
   Mota, J. F.
   Botelho, P. B.
TI Therapeutic potential of green tea on risk factors for type 2 diabetes
   in obese adults - a review
SO OBESITY REVIEWS
LA English
DT Article
DE Camellia sinensis; diabetes mellitus; insulin resistance; obesity
ID RANDOMIZED CONTROLLED-TRIALS; FATTY LIVER-DISEASE; BODY-WEIGHT LOSS;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; OXIDATIVE STRESS; POLYPHENOL
   EPIGALLOCATECHIN-3-GALLATE; ANTIOXIDANT CAPACITY; CAMELLIA-SINENSIS;
   BLOOD-PRESSURE
AB Green tea has been associated with positive effects in the treatment of obesity and other associated comorbidities such as type 2 diabetes. These benefits are thought to be related to the anti-inflammatory and antioxidant effects of green tea and to the reduction in body fat percentage exhibited by its bioactive compounds. The predominant active compounds in green tea are flavonoid monomers known as catechins, in particular epigallocatechin-3-gallate, which is the most abundant and most effective catechin in metabolic care, particularly among obese patients. The objective of this review was to investigate the effects of green tea on body composition, oxidative stress, inflammation and insulin resistance, risk factors for the development of type 2 diabetes in obese individuals and the mechanisms that underlie the modulatory actions of green tea compounds on these risk factors. Although green tea has therapeutic potential in the treatment of obese individuals, the findings of this review demonstrate the need for a greater number of studies to confirm the positive effects of green tea, especially regarding the modulation of obesity.
C1 [Ferreira, M. A.; Silva, D. M.; de Morais, A. C., Jr.; Mota, J. F.; Botelho, P. B.] Fed Univ Goias UFG, Nutr Fac, Lab Res Clin Nutr & Sports Labince, Goiania, Go, Brazil.
C3 Universidade Federal de Goias
RP Botelho, PB (corresponding author), Univ Fed Goias, Fac Nutr, Setor Leste Univ, Rua 227 Qd 68 S-N, BR-74605080 Goiania, Go, Brazil.
EM patriciaborges.nutri@gmail.com
RI de Morais Junior, Alcides/GQQ-5957-2022; Mota, João/AAU-9194-2020; Mota,
   Joao Felipe/I-7507-2012; Botelho, Patricia Borges/AAL-7977-2020
OI Mota, Joao Felipe/0000-0001-6123-7616; Botelho, Patricia
   Borges/0000-0001-8909-3757; de Morais Junior,
   Alcides/0000-0001-5098-881X
FU CAPES
FX Funding and sponsorship CAPES supported this work.
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NR 85
TC 41
Z9 42
U1 2
U2 71
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1467-7881
EI 1467-789X
J9 OBES REV
JI Obes. Rev.
PD DEC
PY 2016
VL 17
IS 12
BP 1316
EP 1328
DI 10.1111/obr.12452
PG 13
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA ED8TW
UT WOS:000389144800010
PM 27443447
DA 2025-06-11
ER

PT J
AU Pereira, RD
   Tatsch, E
   Bochi, GV
   Kober, H
   Duarte, T
   Montagner, GFFD
   da Silva, JEP
   Duarte, MMMF
   da Cruz, IBM
   Moresco, RN
AF Pereira, Renata da Silva
   Tatsch, Etiane
   Bochi, Guilherme Vargas
   Kober, Helena
   Duarte, Thiago
   Feyh dos Santos Montagner, Greice Franciele
   Paz da Silva, Jose Edson
   Medeiros Frescura Duarte, Marta Maria
   Manica da Cruz, Ivana Beatrice
   Moresco, Rafael Noal
TI Assessment of Oxidative, Inflammatory, and Fibrinolytic Biomarkers and
   DNA Strand Breakage in Hypercholesterolemia
SO INFLAMMATION
LA English
DT Article
DE advanced oxidation protein products; fibrinolysis; hypercholesterolemia;
   inflammation; oxidative stress
ID ISCHEMIA-MODIFIED ALBUMIN; CORONARY-ARTERY-DISEASE; C-REACTIVE PROTEIN;
   INEXPENSIVE AUTOMATED TECHNIQUE; TYPE-2 DIABETES-MELLITUS; D-DIMER;
   METABOLIC SYNDROME; NITRIC-OXIDE; HEART-DISEASE; IN-VIVO
AB The aim of this study was to assess the levels of oxidative, inflammatory, and fibrinolytic biomarkers as well as DNA strand breakage in hypercholesterolemic subjects. Fasting glucose, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglycerides, uric acid, total protein, albumin, apolipoprotein (Apo) A, Apo B, advanced oxidation protein products (AOPP), increased ischemia-modified albumin (IMA), aEuro center dot SH, NOx, IL-6, and D-dimer levels were assessed, and DNA strand breakage was evaluated using comet assay in 38 patients with hypercholesterolemia and 20 healthy controls. Total cholesterol, triglycerides, LDL cholesterol, Apo A, Apo B, AOPP, IMA, IL-6, and D-dimer concentrations were significantly higher in subjects with hypercholesterolemia. However, NOx and plasma aEuro center dot SH group concentrations were lower in hypercholesterolemic subjects, while no significant differences were observed with respect to DNA strand breakage between the two groups. Hypercholesterolemia is related to oxidative stress and inflammation. Accordingly, AOPP concentration was higher in subjects with hypercholesterolemia, and we speculate that AOPP can reflect the enhancement of protein oxidation and inflammation.
C1 [Pereira, Renata da Silva; Tatsch, Etiane; Paz da Silva, Jose Edson; Moresco, Rafael Noal] Univ Fed Santa Maria, Programa Posgrad Ciencias Farmaceut, Ctr Ciencias Saude, BR-97105900 Santa Maria, RS, Brazil.
   [Tatsch, Etiane; Bochi, Guilherme Vargas; Kober, Helena; Moresco, Rafael Noal] Univ Fed Santa Maria, Dept Anal Clin & Toxicol, Ctr Ciencias Saude, Lab Pesquisa Bioquim Clin, BR-97105900 Santa Maria, RS, Brazil.
   [Bochi, Guilherme Vargas; Kober, Helena; Duarte, Thiago; Manica da Cruz, Ivana Beatrice; Moresco, Rafael Noal] Univ Fed Santa Maria, Programa Posgrad Farmacol, Ctr Ciencias Saude, BR-97105900 Santa Maria, RS, Brazil.
   [Feyh dos Santos Montagner, Greice Franciele; Manica da Cruz, Ivana Beatrice] Univ Fed Santa Maria, Programa Posgrad Bioquim Toxicol, Ctr Ciencias Nat & Exatas, BR-97105900 Santa Maria, RS, Brazil.
   [Medeiros Frescura Duarte, Marta Maria] Univ Luterana Brasil, Dept Ciencias Saude, Santa Maria, RS, Brazil.
   [Moresco, Rafael Noal] Univ Fed Santa Maria, Dept Anal Clin & Toxicol, Ctr Ciencias Saude, BR-97105900 Santa Maria, RS, Brazil.
C3 Universidade Federal de Santa Maria (UFSM); Universidade Federal de
   Santa Maria (UFSM); Universidade Federal de Santa Maria (UFSM);
   Universidade Federal de Santa Maria (UFSM); Universidade Luterana do
   Brasil; Universidade Federal de Santa Maria (UFSM)
RP Moresco, RN (corresponding author), Univ Fed Santa Maria, Dept Anal Clin & Toxicol, Ctr Ciencias Saude, Ave Roraima 1000,Predio 26,Sala 1401, BR-97105900 Santa Maria, RS, Brazil.
EM rnmoresco@yahoo.com.br
RI França da Silva Junior, José Edson/GVU-7782-2022; Moresco,
   Rafael/K-6118-2017; da Cruz; Manica da Cruz, Ivana/G-4329-2012
OI Bochi, Guilherme/0000-0003-1871-1356; Moresco,
   Rafael/0000-0003-3072-5080; da Cruz; Manica da Cruz,
   Ivana/0000-0003-3008-6899
FU CAPES; Conselho Nacional de Desenvolvimento Cientifico e Tecnologico
   (CNPq)
FX E. Tatsch and G. V. Bochi are recipients of CAPES Doctorate degree
   fellowship. R.N. Moresco and I. B. M. Da Cruz are recipients of research
   grants from Conselho Nacional de Desenvolvimento Cientifico e
   Tecnologico (CNPq).
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NR 66
TC 17
Z9 17
U1 0
U2 5
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0360-3997
EI 1573-2576
J9 INFLAMMATION
JI Inflammation
PD AUG
PY 2013
VL 36
IS 4
BP 869
EP 877
DI 10.1007/s10753-013-9614-2
PG 9
WC Cell Biology; Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Immunology
GA 181AV
UT WOS:000321641300011
PM 23436135
DA 2025-06-11
ER

PT J
AU Brandhorst, S
AF Brandhorst, Sebastian
TI Fasting and fasting-mimicking diets for chemotherapy augmentation
SO GEROSCIENCE
LA English
DT Article
DE Cancer; Chemotherapy; Fasting; Fasting-mimicking diet
ID MAMMARY-TUMOR INCIDENCE; DISEASE RISK MARKERS; GROWTH-FACTOR-I; CALORIC
   RESTRICTION; LIFE-SPAN; CANCER-CELLS; STRESS RESISTANCE; SPONTANEOUS
   TUMORIGENESIS; MOLECULAR-MECHANISMS; PROTEIN RESTRICTION
AB The increasingly older population in most developed countries will likely experience aging-related chronic diseases such as diabetes, metabolic syndrome, heart and lung diseases, osteoporosis, arthritis, dementia, and/or cancer. Genetic and environmental factors, but also lifestyle choices including physical activity and dietary habits, play essential roles in disease onset and progression. Sixty-five percent of Americans diagnosed with cancer now survive more than 5 years, making the need for informed lifestyle choices particularly important to successfully complete their treatment, increase the recovery from the cytotoxic therapy options, and improve cancer-free survival. This review will discuss the findings on the use of prolonged fasting, as well as fasting-mimicking diets to augment cancer treatment. Preclinical studies in rodents strongly support the implementation of these dietary interventions and a small number of clinical trials begin to provide encouraging results for cancer patients and cancer survivors.
C1 [Brandhorst, Sebastian] Univ Southern Calif, Sch Gerontol, Longev Inst, Los Angeles, CA 90089 USA.
   [Brandhorst, Sebastian] Univ Southern Calif, Dept Biol Sci, Los Angeles, CA 90089 USA.
C3 University of Southern California; University of Southern California
RP Brandhorst, S (corresponding author), Univ Southern Calif, Sch Gerontol, Longev Inst, Los Angeles, CA 90089 USA.; Brandhorst, S (corresponding author), Univ Southern Calif, Dept Biol Sci, Los Angeles, CA 90089 USA.
EM brandhor@usc.edu
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NR 135
TC 26
Z9 27
U1 2
U2 42
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 2509-2715
EI 2509-2723
J9 GEROSCIENCE
JI GeroScience
PD JUN
PY 2021
VL 43
IS 3
SI SI
BP 1201
EP 1216
DI 10.1007/s11357-020-00317-7
EA JAN 2021
PG 16
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA SQ7HY
UT WOS:000605511400001
PM 33410090
OA Green Published
DA 2025-06-11
ER

PT J
AU Lee, WS
   Kim, J
AF Lee, Wang-Soo
   Kim, Jaetaek
TI Diabetic cardiomyopathy: where we are and where we are going
SO KOREAN JOURNAL OF INTERNAL MEDICINE
LA English
DT Review
DE Diabetic cardiomyopathies; Heart failure; Diabetes mellitus
ID CHRONIC HEART-FAILURE; CARDIAC AUTONOMIC NEUROPATHY; LEFT-VENTRICULAR
   DYSFUNCTION; ACTIVATED RECEPTOR-GAMMA; INSULIN-RESISTANCE; DIASTOLIC
   DYSFUNCTION; MOUSE MODEL; CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME;
   OXIDATIVE STRESS
AB The global burden of diabetes mellitus and its related complications are currently increasing. Diabetes mellitus affects the heart through various mechanisms including microvascular impairment, metabolic disturbance, subcellular component abnormalities, cardiac autonomic dysfunction, and a maladaptive immune response. Eventually, diabetes mellitus can cause functional and structural changes in the myocardium without coronary artery disease, a disorder known as diabetic cardiomyopathy (DCM). There are many diagnostic tools and management options for DCM, although it is difficult to detect its development and effectively prevent its progression. In this review, we summarize the current research regarding the pathophysiology and pathogenesis of DCM. Moreover, we discuss emerging diagnostic evaluation methods and treatment strategies for DCM, which may help our understanding of its underlying mechanisms and facilitate the identification of possible new therapeutic targets.
C1 [Lee, Wang-Soo] Chung Ang Univ, Coll Med, Div Cardiol, Dept Internal Med, Seoul, South Korea.
   [Kim, Jaetaek] Chung Ang Univ, Coll Med, Dept Internal Med, Div Endocrinol & Metab, Seoul, South Korea.
C3 Chung Ang University; Chung Ang University Hospital; Chung Ang
   University; Chung Ang University Hospital
RP Kim, J (corresponding author), Chung Ang Univ Hosp, Dept Internal Med, Div Endocrinol & Metab, 102 Heukseok Ro, Seoul 06973, South Korea.
EM jtkim@cau.ac.kr
RI Lee, Wang-Soo/AAS-1477-2021; Kim, Jaetaek/AAE-7147-2020
OI Lee, Wang-Soo/0000-0002-8264-0866
FU Basic Science Research Program through the National Research Foundation
   of Korea (NRF) - Korean Government [2016R1A4A1009895, 2012R1A1A2008177]
FX This work was supported by grants of the Basic Science Research Program
   through the National Research Foundation of Korea (NRF) funded by the
   Korean Government (2016R1A4A1009895 and 2012R1A1A2008177).
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NR 139
TC 119
Z9 132
U1 0
U2 12
PU KOREAN ASSOC INTERNAL MEDICINE
PI SEOUL
PA 101-2501 LOTTE CASTLE PRESIDENT, 109 MAPO-DAERO, MAPO-GU, SEOUL,
   121-916, SOUTH KOREA
SN 1226-3303
EI 2005-6648
J9 KOREAN J INTERN MED
JI Korean J. Intern. Med.
PD MAY
PY 2017
VL 32
IS 3
BP 404
EP 421
DI 10.3904/kjim.2016.208
PG 18
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA EU4PZ
UT WOS:000401013600003
PM 28415836
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Ekaterina
   Fomenko, V
   Chi, YL
AF Ekaterina
   Fomenko, Vladimirovna
   Chi, Yuling
TI Mangiferin modulation of metabolism and metabolic syndrome
SO BIOFACTORS
LA English
DT Review
DE Mangiferin; metabolism; inflammation; hyperlipidemia; hyperglycemia
ID GLYCATION END-PRODUCTS; NF-KAPPA-B; DIABETIC-NEPHROPATHY PROGRESSION;
   OXIDATIVE STRESS; SALACIA-RETICULATA; DIACYLGLYCEROL ACYLTRANSFERASE-2;
   INSULIN-RESISTANCE; LIPID-PEROXIDATION; HEPATIC STEATOSIS; NATURAL
   XANTHONE
AB The recent emergence of a worldwide epidemic of metabolic disorders, such as obesity and diabetes, demands effective strategy to develop nutraceuticals or pharmaceuticals to halt this trend. Natural products have long been and continue to be an attractive source of nutritional and pharmacological therapeutics. One such natural product is mangiferin (MGF), the predominant constituent of extracts of the mango plant Mangifera indica L. Reports on biological and pharmacological effects of MGF increased exponentially in recent years. MGF has documented antioxidant and anti-inflammatory effects. Recent studies indicate that it modulates multiple biological processes involved in metabolism of carbohydrates and lipids. MGF has been shown to improvemetabolic abnormalities and disorders in animal models and humans. This review focuses on the recently reported biological and pharmacological effects of MGF on metabolism and metabolic disorders. (C) 2016 BioFactors.
C1 [Ekaterina; Fomenko, Vladimirovna; Chi, Yuling] Albert Einstein Coll Med, Dept Med, Ullmann 617,1300 Morris Pk Ave, Bronx, NY 10461 USA.
C3 Montefiore Medical Center; Albert Einstein College of Medicine; Yeshiva
   University
RP Chi, YL (corresponding author), Albert Einstein Coll Med, Dept Med, Ullmann 617,1300 Morris Pk Ave, Bronx, NY 10461 USA.
EM yuling.chi@einstein.yu.edu
OI Fomenko, Ekaterina/0009-0006-6678-6124
FU American Heart Association [0735066N]; American Diabetes Association
   [1-11-JF-06]; NIH/NIDDK [DK41296]
FX This work was supported by the grants that Y.C. received from the
   American Heart Association (0735066N), from American Diabetes
   Association (1-11-JF-06), and partially from NIH/NIDDK (DK41296).
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NR 120
TC 40
Z9 43
U1 2
U2 42
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0951-6433
EI 1872-8081
J9 BIOFACTORS
JI Biofactors
PD SEP-OCT
PY 2016
VL 42
IS 5
SI SI
BP 492
EP 503
DI 10.1002/biof.1309
PG 12
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA EI8CR
UT WOS:000392733000004
PM 27534809
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Koene, RJ
   Prizment, AE
   Blaes, A
   Konety, SH
AF Koene, Ryan J.
   Prizment, Anna E.
   Blaes, Anne
   Konety, Suma H.
TI Shared Risk Factors in Cardiovascular Disease and Cancer
SO CIRCULATION
LA English
DT Review
DE cardiology; cardiovascular diseases; clinical oncology; risk factors
ID RENAL-CELL CANCER; IGF-BINDING PROTEIN-3; ALCOHOL-CONSUMPTION;
   BREAST-CANCER; GROWTH-FACTOR; METABOLIC SYNDROME; PHYSICAL-ACTIVITY;
   OXIDATIVE STRESS; TOBACCO SMOKING; STATIN USE
AB Cardiovascular disease (CVD) and cancer are the 2 leading causes of death worldwide. Although commonly thought of as 2 separate disease entities, CVD and cancer possess various similarities and possible interactions, including a number of similar risk factors (eg, obesity, diabetes mellitus), suggesting a shared biology for which there is emerging evidence. Although chronic inflammation is an indispensable feature of the pathogenesis and progression of both CVD and cancer, additional mechanisms can be found at their intersection. Therapeutic advances, despite improving longevity, have increased the overlap between these diseases, with millions of cancer survivors now at risk of developing CVD. Cardiac risk factors have a major impact on subsequent treatment-related cardiotoxicity. In this review, we explore the risk factors common to both CVD and cancer, highlighting the major epidemiological studies and potential biological mechanisms that account for them.
C1 [Koene, Ryan J.; Konety, Suma H.] Univ Minnesota, Dept Med, Div Cardiovasc Med, Box 736 UMHC, Minneapolis, MN 55455 USA.
   [Prizment, Anna E.] Univ Minnesota, Dept Epidemiol & Community Hlth, Minneapolis, MN 55455 USA.
   [Blaes, Anne] Univ Minnesota, Dept Med, Div Oncol, Box 736 UMHC, Minneapolis, MN 55455 USA.
   [Prizment, Anna E.] Univ Minnesota, Masonic Canc Ctr, Minneapolis, MN 55455 USA.
C3 University of Minnesota System; University of Minnesota Twin Cities;
   University of Minnesota System; University of Minnesota Twin Cities;
   University of Minnesota System; University of Minnesota Twin Cities;
   University of Minnesota System; University of Minnesota Twin Cities
RP Koene, RJ (corresponding author), Univ Minnesota, 420 Delaware St SE,MMC 508, Minneapolis, MN 55455 USA.
EM koene030@umn.edu
FU National Center for Advancing Translational Sciences of the National
   Institutes of Health [UL1 TR000114]
FX Dr Prizment was supported by the National Center for Advancing
   Translational Sciences of the National Institutes of Health (Award
   Number UL1 TR000114).
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NR 113
TC 1050
Z9 1100
U1 10
U2 134
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0009-7322
EI 1524-4539
J9 CIRCULATION
JI Circulation
PD MAR 15
PY 2016
VL 133
IS 11
BP 1104
EP 1114
DI 10.1161/CIRCULATIONAHA.115.020406
PG 11
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA DG3ZE
UT WOS:000372008900008
PM 26976915
OA Green Accepted
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Burgio, KL
   Newman, DK
   Rosenberg, MT
   Sampselle, C
AF Burgio, K. L.
   Newman, D. K.
   Rosenberg, M. T.
   Sampselle, C.
TI Impact of behaviour and lifestyle on bladder health
SO INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
LA English
DT Review
ID URINARY-TRACT SYMPTOMS; BENIGN PROSTATIC HYPERPLASIA; OVERACTIVE
   BLADDER; CIGARETTE-SMOKING; RISK-FACTORS; FLUID INTAKE; CHRONIC
   CONSTIPATION; STRESS-INCONTINENCE; ALCOHOL-CONSUMPTION; METABOLIC
   SYNDROME
AB Bladder conditions, including UTI, UI, and bladder cancer, are highly prevalent and affect a wide range of populations. There are a variety of modifiable behavioral and lifestyle factors that influence bladder health. Some factors, such as smoking and obesity, increase the risk or severity of bladder conditions, whereas other factors, such as pelvic floor muscle exercise, are protective. Although clinical practice may be assumed to be the most appropriate ground for education on behavioral and lifestyle factors that influence bladder health, it is also crucial to extend these messages into the general population through public health interventions to reach those who have not yet developed bladder conditions and to maximize the prevention impact of these behaviors. Appropriate changes in these factors have the potential for an enormous impact on bladder health if implemented on a population-based level.
C1 [Burgio, K. L.] Dept Vet Affairs Med Ctr, Birmingham, AL USA.
   [Burgio, K. L.] Univ Alabama Birmingham, Dept Med, Birmingham, AL 35294 USA.
   [Newman, D. K.] Univ Penn, Perelman Sch Med, Div Urol, Philadelphia, PA 19104 USA.
   [Rosenberg, M. T.] Midmichigan Hlth Ctr, Jackson, MI USA.
   [Sampselle, C.] Univ Michigan, Sch Nursing, Div Hlth Promot & Risk Reduct, Ann Arbor, MI 48109 USA.
C3 University of Alabama System; University of Alabama Birmingham;
   University of Pennsylvania; University of Michigan System; University of
   Michigan
RP Burgio, KL (corresponding author), Birmingham VA Med Ctr, Geriatr Res Educ & Clin Ctr, 700 South 19th St, Birmingham, AL 35233 USA.
EM kburgio@uabmc.edu
FU Pfizer Inc.
FX Funding for two expert panel meetings on bladder health, at which this
   manuscript was conceptualised, was provided by Pfizer Inc. Editorial
   assistance was provided by Nicole Lodowski of Pfizer Inc and Colin P.
   Mitchell, PhD, of Complete Healthcare Communications, Inc. and was
   funded by Pfizer Inc.
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NR 100
TC 25
Z9 27
U1 0
U2 29
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1368-5031
EI 1742-1241
J9 INT J CLIN PRACT
JI Int. J. Clin. Pract.
PD JUN
PY 2013
VL 67
IS 6
BP 495
EP 504
DI 10.1111/ijcp.12143
PG 10
WC Medicine, General & Internal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine; Pharmacology & Pharmacy
GA 146BJ
UT WOS:000319063500005
PM 23679903
OA Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Obeid, R
   Herrmann, W
AF Obeid, Rima
   Herrmann, Wolfgang
TI Homocysteine and lipids: S-Adenosyl methionine as a key intermediate
SO FEBS LETTERS
LA English
DT Review
DE Homocysteine; Cholesterol; Choline; Phosphatidylcholine; Betaine;
   Methionine
ID ENDOPLASMIC-RETICULUM STRESS; CYSTATHIONINE BETA-SYNTHASE;
   LOW-DENSITY-LIPOPROTEIN; CHOLINE-DEFICIENT DIET; ADENOSYLHOMOCYSTEINE
   HYDROLASE DEFICIENCY; ALCOHOLIC LIVER-DISEASE; A-I EXPRESSION; PLASMA
   HOMOCYSTEINE; PHOSPHATIDYLCHOLINE SYNTHESIS; PHOSPHATIDYLETHANOLAMINE
   METHYLATION
AB An association between hyperlipidemia and hyperhomocysteinemia (HHCY) has been suggested. This link is clinically important in management of vascular risk factors especially in elderly people and patients with metabolic syndrome. Higher plasma homocysteine (Hcy) was associated with lower high-density lipoprotein (HDL)-cholesterol level. Moreover, HHCY was associated with disturbed plasma lipids or fatty liver. It seems that hypomethylation associated with HHCY is responsible for lipid accumulation in tissues. Decreased methyl group will decrease the synthesis of phosphatidylcholine, a major phospholipid required for very low-density lipoprotein ( VLDL) assembly and homeostasis. The effect of Hcy on HDL-cholesterol is probably related to inhibiting enzymes or molecules participating in HDL-particle assembly. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
C1 [Obeid, Rima; Herrmann, Wolfgang] Univ Saarland, Univ Hosp, Dept Clin Chem & Lab Med, Cent Lab, D-66424 Homburg, Germany.
C3 Saarland University; Universitatsklinikum des Saarlandes
RP Herrmann, W (corresponding author), Univ Saarland, Univ Hosp, Dept Clin Chem & Lab Med, Cent Lab, D-66424 Homburg, Germany.
EM kchwher@uniklinikum-saarland.de
RI Obeid, Rima/AAR-9906-2020
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NR 109
TC 145
Z9 162
U1 0
U2 27
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0014-5793
EI 1873-3468
J9 FEBS LETT
JI FEBS Lett.
PD APR 17
PY 2009
VL 583
IS 8
BP 1215
EP 1225
DI 10.1016/j.febslet.2009.03.038
PG 11
WC Biochemistry & Molecular Biology; Biophysics; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Cell Biology
GA 438OT
UT WOS:000265565700001
PM 19324042
OA Bronze
DA 2025-06-11
ER

PT J
AU Durante, W
   Johnson, FK
   Johnson, RA
AF Durante, WiRiam
   Johnson, Fruzsina K.
   Johnson, Robert A.
TI Role of carbon monoxide in cardiovascular function
SO JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
LA English
DT Review
DE carbon monoxide; heme oxygenase-1; vascular smooth muscle; endothelium;
   atherosclerosis; restenosis; ischemia-reperfusion; blood pressure
ID HEME OXYGENASE-1 GENE; VASCULAR SMOOTH-MUSCLE; ATHEROSCLEROTIC LESION
   FORMATION; ISCHEMIA-REPERFUSION INJURY; CORONARY-ARTERY DISEASE;
   CO-RELEASING MOLECULE; MICROSATELLITE POLYMORPHISM; ENDOTHELIAL
   DYSFUNCTION; BLOOD-PRESSURE; OXIDATIVE STRESS
AB Carbon monoxide (CO) is an endogenously derived gas formed from the breakdown of heme by the enzyme heme oxygenase. Although long considered an insignificant and potentially toxic waste product of heme catabolism, CO is now recognized as a key signaling molecule that regulates numerous cardiovascular functions. Interestingly, alterations in CO synthesis are associated with many cardiovascular disorders, including atherosclerosis, septic shock, hypertension, metabolic syndrome, and ischemia-reperftision injury. Significantly, restoration of physiologic CO levels exerts a beneficial effect in many of these settings, suggesting a crucial role for CO in maintaining cardiovascular homeostasis. In this review, we outline the actions of CO in the cardiovascular system and highlight this gas as a potential therapeutic target in treating a multitude of cardiovascular disorders.
C1 Univ Missouri, Sch Med, Dept Med Pharmacol & Physiol, Columbia, MO 65212 USA.
   Univ Texas, Hlth Sci Ctr, Dept Surg, San Antonio, TX 78284 USA.
   Trauma Inst San Antonio, TRISAT, San Antonio, TX USA.
C3 University of Missouri System; University of Missouri Columbia;
   University of Texas System; University of Texas Health Science Center at
   San Antonio
RP Durante, W (corresponding author), Univ Missouri, Sch Med, Dept Med Pharmacol & Physiol, M409 Med Sci Bldg, Columbia, MO 65212 USA.
EM durantew@health.missouri.edu
FU NCRR NIH HHS [P20 RR17659] Funding Source: Medline; NHLBI NIH HHS [R01
   HL59976, R01 HL76187, R01 HL74966] Funding Source: Medline
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NR 115
TC 118
Z9 127
U1 2
U2 13
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1582-1838
EI 1582-4934
J9 J CELL MOL MED
JI J. Cell. Mol. Med.
PD JUL-SEP
PY 2006
VL 10
IS 3
BP 672
EP 686
DI 10.1111/j.1582-4934.2006.tb00427.x
PG 15
WC Cell Biology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Research & Experimental Medicine
GA 096RI
UT WOS:000241394100009
PM 16989727
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Zhou, WY
   Cheng, YY
   Zhu, P
   Nasser, MI
   Zhang, XY
   Zhao, MY
AF Zhou, Wenyi
   Cheng, Yiyu
   Zhu, Ping
   Nasser, M., I
   Zhang, Xueyan
   Zhao, Mingyi
TI Implication of Gut Microbiota in Cardiovascular Diseases
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Review
ID TRIMETHYLAMINE-N-OXIDE; CHAIN FATTY-ACIDS; HEART-FAILURE; INTESTINAL
   MICROBIOTA; METABOLIC SYNDROME; EPITHELIAL-CELLS; BLOOD-PRESSURE;
   INFLAMMATION; MICE; ATHEROSCLEROSIS
AB Emerging evidence has identified the association between gut microbiota and various diseases, including cardiovascular diseases (CVDs). Altered intestinal flora composition has been described in detail in CVDs, such as hypertension, atherosclerosis, myocardial infarction, heart failure, and arrhythmia. In contrast, the importance of fermentation metabolites, such as trimethylamine N-oxide (TMAO), short-chain fatty acids (SCFAs), and secondary bile acid (BA), has also been implicated in CVD development, prevention, treatment, and prognosis. The potential mechanisms are conventionally thought to involve immune regulation, host energy metabolism, and oxidative stress. However, numerous types of programmed cell death, including apoptosis, autophagy, pyroptosis, ferroptosis, and clockophagy, also serve as a key link in microbiome-host cross talk. In this review, we introduced and summarized the results from recent studies dealing with the relationship between gut microbiota and cardiac disorders, highlighting the role of programmed cell death. We hope to shed light on microbiota-targeted therapeutic strategies in CVD management.
C1 [Zhou, Wenyi; Cheng, Yiyu; Zhang, Xueyan; Zhao, Mingyi] Cent South Univ, Xiangya Hosp 3, Dept Pediat, Changsha 410013, Hunan, Peoples R China.
   [Zhou, Wenyi; Zhu, Ping; Nasser, M., I] Guangdong Acad Med Sci, Guangdong Prov Peoples Hosp, Guangdong Cardiovasc Inst, Guangzhou 510100, Guangdong, Peoples R China.
C3 Central South University; Guangdong Academy of Medical Sciences &
   Guangdong General Hospital; Southern Medical University - China
RP Zhao, MY (corresponding author), Cent South Univ, Xiangya Hosp 3, Dept Pediat, Changsha 410013, Hunan, Peoples R China.
EM 36163773@qq.com
RI Nasser, Moussa/AAI-4630-2020
OI Zhou, Wenyi/0000-0002-9958-3458; xueyan, zhang/0000-0001-6399-7926;
   Nasser, Moussa Ide/0000-0002-2670-6496; Cheng, Yiyu/0000-0003-1423-162X;
   Zhao, Mingyi/0000-0002-2884-0736; Nasser, Moussa Ide/0000-0003-3685-748X
FU National Key Research and Development Program of China [2018YFA0108700];
   NSFC Projects of International Cooperation and Exchanges [81720102004];
   National Natural Science Foundation of China [81974019, 81970248];
   National Training Program of Innovation and Entrepreneurship for
   Undergraduates [2020105330125]
FX This research was funded by the National Key Research and Development
   Program of China (2018YFA0108700), the NSFC Projects of International
   Cooperation and Exchanges (81720102004), the National Natural Science
   Foundation of China (81974019, 81970248), and the National Training
   Program of Innovation and Entrepreneurship for Undergraduates
   (2020105330125). AJE edited the manuscript for grammar, punctuation and
   spelling.
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NR 125
TC 100
Z9 103
U1 3
U2 79
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PD SEP 26
PY 2020
VL 2020
AR 5394096
DI 10.1155/2020/5394096
PG 14
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA OB2PN
UT WOS:000578315800001
PM 33062141
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Turrini, E
   Ferruzzi, L
   Fimognari, C
AF Turrini, Eleonora
   Ferruzzi, Lorenzo
   Fimognari, Carmela
TI Possible Effects of Dietary Anthocyanins on Diabetes and Insulin
   Resistance
SO CURRENT DRUG TARGETS
LA English
DT Review
DE Anthocyanins; anthocyanidins; antioxidant activity; cyanidin; diabetes;
   enzymatic mechanisms; non-enzymatic mechanisms
ID EXTRACT AMELIORATES HYPERGLYCEMIA; ACTIVATED PROTEIN-KINASE; OXIDATIVE
   STRESS; HEPATIC STEATOSIS; ALPHA-GLUCOSIDASE; GENE-EXPRESSION;
   PROTOCATECHUIC ACID; METABOLIC SYNDROME; POMEGRANATE JUICE; BERRY
   POLYPHENOLS
AB Diabetes is reaching epidemic proportions worldwide. Many dietary compounds have been found to exert health beneficial effects against different pathologies including diabetes. Most bioactive compounds have been identified in fruits and vegetables and their mechanisms of action explored both in vitro and in vivo. In particular, great interest has been given to polyphenols and especially to a specific subset of molecules, i.e. anthocyanins. Several lines of evidence suggest that anthocyanins have positive effects on human health by inducing a number of biological activities. This review will give an overview on the influence of dietary anthocyanins on preventing and managing type 2 diabetes. In particular, in vitro and in vivo studies will be presented. The article also reviews the potential clinical impact of the antidiabetic activity of anthocyanins and outlines the major challenges of using anthocyanins for diabetes treatment.
C1 [Turrini, Eleonora; Ferruzzi, Lorenzo; Fimognari, Carmela] Alma Mater Studiorum Univ Bologna, Dept Life Qual Studies, Corso Augusto 237, I-47921 Rimini, Italy.
C3 University of Bologna
RP Fimognari, C (corresponding author), Alma Mater Studiorum Univ Bologna, Dept Life Qual Studies, Corso Augusto 237, I-47921 Rimini, Italy.
EM mailcarmela.fimognari@unibo.it
RI Turrini, Eleonora/I-3629-2019; Fimognari, Carmela/J-7678-2019
OI Fimognari, Carmela/0000-0002-2461-8214
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NR 100
TC 19
Z9 21
U1 2
U2 51
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1389-4501
EI 1873-5592
J9 CURR DRUG TARGETS
JI Curr. Drug Targets
PY 2017
VL 18
IS 6
BP 629
EP 640
DI 10.2174/1389450116666151001105230
PG 12
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA EW4HD
UT WOS:000402461700003
PM 26424400
DA 2025-06-11
ER

PT J
AU Caligiuri, A
   Gentilini, A
   Marra, F
AF Caligiuri, Alessandra
   Gentilini, Alessandra
   Marra, Fabio
TI Molecular Pathogenesis of NASH
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE fibrosis; inflammation; chemokines; genetics; microbiota;
   pattern-recognition receptors; nuclear receptors; hepatic stellate
   cells; macrophages
ID FATTY LIVER-DISEASE; ENDOPLASMIC-RETICULUM STRESS; PREGNANE-X-RECEPTOR;
   NLRP3 INFLAMMASOME ACTIVATION; HEDGEHOG PATHWAY ACTIVATION;
   UNFOLDED-PROTEIN-RESPONSE; INTESTINAL BACTERIAL OVERGROWTH; HEPATIC
   STELLATE CELLS; LINKS INNATE IMMUNITY; NECROSIS-FACTOR-ALPHA
AB Nonalcoholic steatohepatitis (NASH) is the main cause of chronic liver disease in the Western world and a major health problem, owing to its close association with obesity, diabetes, and the metabolic syndrome. NASH progression results from numerous events originating within the liver, as well as from signals derived from the adipose tissue and the gastrointestinal tract. In a fraction of NASH patients, disease may progress, eventually leading to advanced fibrosis, cirrhosis and hepatocellular carcinoma. Understanding the mechanisms leading to NASH and its evolution to cirrhosis is critical to identifying effective approaches for the treatment of this condition. In this review, we focus on some of the most recent data reported on the pathogenesis of NASH and its fibrogenic progression, highlighting potential targets for treatment or identification of biomarkers of disease progression.
C1 [Caligiuri, Alessandra; Gentilini, Alessandra; Marra, Fabio] Univ Florence, Dipartimento Med Sperimentale & Clin, I-50121 Florence, Italy.
C3 University of Florence
RP Marra, F (corresponding author), Univ Florence, Dipartimento Med Sperimentale & Clin, I-50121 Florence, Italy.
EM alessandra.caligiuri@unifi.it; alessandra.gentilini@unifi.it;
   fabio.marra@unifi.it
RI Gentilini, Alessandra/GWQ-9235-2022; Marra, Fabio/K-7263-2016
OI Marra, Fabio/0000-0001-8629-0878; gentilini,
   alessandra/0000-0001-7692-390X
FU Italian Ministry for Research; European Community; CARIPLO Foundation
FX Work on steatohepatitis in Marra's laboratory is supported by grants
   from the Italian Ministry for Research (Projects PRIN and FIRB), the
   European Community (projects FLIP and EPoS), and the CARIPLO Foundation.
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NR 329
TC 148
Z9 159
U1 7
U2 49
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD SEP
PY 2016
VL 17
IS 9
AR 1575
DI 10.3390/ijms17091575
PG 34
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA DZ0JU
UT WOS:000385525500189
PM 27657051
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Kotlyarov, S
AF Kotlyarov, Stanislav
TI Immune and metabolic cross-links in the pathogenesis of comorbid
   non-alcoholic fatty liver disease
SO WORLD JOURNAL OF GASTROENTEROLOGY
LA English
DT Review
DE Non-alcoholic fatty liver disease; Metabolism; Lipid metabolism; Lipid;
   Fat; Innate immune system; Pathogenesis
ID SINUSOIDAL ENDOTHELIAL-CELLS; ESTER TRANSFER PROTEIN; TOLL-LIKE
   RECEPTORS; ENDOPLASMIC-RETICULUM STRESS; NITRIC-OXIDE;
   INSULIN-RESISTANCE; KUPFFER CELLS; SCAVENGER RECEPTOR;
   CARDIOVASCULAR-DISEASE; LIPID-ACCUMULATION
AB In recent years, there has been a steady growth of interest in non-alcoholic fatty liver disease (NAFLD), which is associated with negative epidemiological data on the prevalence of the disease and its clinical significance. NAFLD is closely related to the metabolic syndrome and these relationships are the subject of active research. A growing body of evidence shows cross-linkages between metabolic abnormalities and the innate immune system in the development and progression of NAFLD. These links are bidirectional and largely still unclear, but a better understanding of them will improve the quality of diagnosis and management of patients. In addition, lipid metabolic disorders and the innate immune system link NAFLD with other diseases, such as atherosclerosis, which is of great clinical importance.
C1 [Kotlyarov, Stanislav] Ryazan State Med Univ, Dept Nursing, Vysokovoltnaya St 9, Ryazan 390026, Russia.
C3 Ryazan State Medical University
RP Kotlyarov, S (corresponding author), Ryazan State Med Univ, Dept Nursing, Vysokovoltnaya St 9, Ryazan 390026, Russia.
EM skmr1@yandex.ru
RI Kotlyarov, Stanislav/Q-3633-2017
OI Kotlyarov, Stanislav/0000-0002-7083-2692
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U2 2
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 7041 Koll Center Parkway, Suite 160, PLEASANTON, CA, UNITED STATES
SN 1007-9327
EI 2219-2840
J9 WORLD J GASTROENTERO
JI World J. Gastroenterol.
PD JAN 28
PY 2023
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WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 8Y1AH
UT WOS:000932434500002
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OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Adin, CA
AF Adin, Christopher A.
TI Bilirubin as a Therapeutic Molecule: Challenges and Opportunities
SO ANTIOXIDANTS
LA English
DT Review
DE bilirubin; antioxidant; ischemia-reperfusion; Gilbert's Syndrome;
   nanoparticle; synthetic
ID ISCHEMIA-REPERFUSION INJURY; HIGHER SERUM BILIRUBIN; UNCONJUGATED
   BILIRUBIN; HEME OXYGENASE-1; CARDIOVASCULAR-DISEASE; OXIDATIVE STRESS;
   BILIVERDIN REDUCTASE; UGT1A1-ASTERISK-28 ALLELE; INVERSE ASSOCIATION;
   PLASMA BILIRUBIN
AB There is strong evidence that serum free bilirubin concentration has significant effects on morbidity and mortality in the most significant health conditions of our times, including cardiovascular disease, diabetes, and obesity/metabolic syndrome. Supplementation of bilirubin in animal and experimental models has reproduced these protective effects, but several factors have slowed the application bilirubin as a therapeutic agent in human patients. Bilirubin is poorly soluble in water, and is a complex molecule that is difficult to synthesize. Current sources of this molecule are animal-derived, creating concerns regarding the risk of virus or prion transmission. However, recent developments in nanoparticle drug delivery, biosynthetic strategies, and drug synthesis have opened new avenues for applying bilirubin as a pharmaceutical agent. This article reviews the chemistry and physiology of bilirubin, potential clinical applications and summarizes current strategies for safe and efficient drug delivery.
C1 [Adin, Christopher A.] Univ Florida, Dept Small Anim Clin Sci, Gainesville, FL 32610 USA.
C3 State University System of Florida; University of Florida
RP Adin, CA (corresponding author), Univ Florida, Dept Small Anim Clin Sci, Gainesville, FL 32610 USA.
EM adinc@ufl.edu
OI Adin, Christopher/0000-0001-7677-7711
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NR 105
TC 56
Z9 56
U1 6
U2 47
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD OCT
PY 2021
VL 10
IS 10
AR 1536
DI 10.3390/antiox10101536
PG 16
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA WN4BD
UT WOS:000711714300001
PM 34679671
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Brown, NK
   Zhou, Z
   Zhang, JF
   Zeng, R
   Wu, JR
   Eitzman, DT
   Chen, YE
   Chang, L
AF Brown, Nicholas K.
   Zhou, Zhou
   Zhang, Jifeng
   Zeng, Rong
   Wu, Jiarui
   Eitzman, Daniel T.
   Chen, Y. Eugene
   Chang, Lin
TI Perivascular Adipose Tissue in Vascular Function and Disease A Review of
   Current Research and Animal Models
SO ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
LA English
DT Article
DE adipose tissue; atherosclerosis; hypertension
ID CORONARY ENDOTHELIAL DYSFUNCTION; NITRIC-OXIDE SYNTHASE; E-DEFICIENT
   MICE; SMOOTH-MUSCLE; BROWN-FAT; OXIDATIVE STRESS; WHITE FAT; METABOLIC
   SYNDROME; BEIGE ADIPOCYTES; BLOOD-PRESSURE
AB Perivascular adipose tissue (PVAT), long assumed to be nothing more than vessel-supporting connective tissue, is now understood to be an important, active component of the vasculature, with integral roles in vascular health and disease. PVAT is an adipose tissue with similarities to both brown and white adipose tissue, although recent evidence suggests that PVAT develops from its own precursors. Like other adipose tissue depots, PVAT secretes numerous biologically active substances that can act in both autocrine and paracrine fashion. PVAT has also proven to be involved in vascular inflammation. Although PVAT can support inflammation during atherosclerosis via macrophage accumulation, emerging evidence suggests that PVAT also has antiatherosclerotic properties related to its abilities to induce nonshivering thermogenesis and metabolize fatty acids. We here discuss the accumulated knowledge of PVAT biology and related research on models of hypertension and atherosclerosis.
C1 [Brown, Nicholas K.; Zhou, Zhou; Zhang, Jifeng; Eitzman, Daniel T.; Chen, Y. Eugene; Chang, Lin] Univ Michigan, Med Ctr, Dept Internal Med, Cardiovasc Ctr, Ann Arbor, MI 48109 USA.
   [Brown, Nicholas K.] Childrens Natl Med Ctr, Ctr Canc & Immunol Res, Washington, DC 20010 USA.
   [Zeng, Rong; Wu, Jiarui] Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Shanghai, Peoples R China.
C3 University of Michigan System; University of Michigan; Children's
   National Health System; Chinese Academy of Sciences; Center for
   Excellence in Molecular Cell Science, CAS
RP Chang, L (corresponding author), Univ Michigan, Med Ctr, Dept Internal Med, Cardiovasc Ctr, 2800 Plymouth Rd, Ann Arbor, MI 48109 USA.
EM echenum@umich.edu; lincha@umich.edu
RI Brown, Nicholas/AAG-1825-2021; Zeng, Rong/P-2269-2017; wu,
   jia/LRC-1145-2024; Zhou, Zhou/R-7788-2016
OI Brown, Nicholas/0000-0002-0046-2315
FU National Institutes of Health [HL068878, HL105114, HL088391]; American
   Heart Association National Scientist Development Grant [09SDG2230270];
   American Heart Association (AHA) [09SDG2230270] Funding Source: American
   Heart Association (AHA)
FX This work was supported by the National Institutes of Health grants
   HL068878, HL105114, and HL088391 (to Y.E. Chen) and by the American
   Heart Association National Scientist Development Grant (09SDG2230270 to
   L. Chang).
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NR 98
TC 243
Z9 267
U1 0
U2 45
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1079-5642
EI 1524-4636
J9 ARTERIOSCL THROM VAS
JI Arterioscler. Thromb. Vasc. Biol.
PD AUG
PY 2014
VL 34
IS 8
BP 1621
EP 1630
DI 10.1161/ATVBAHA.114.303029
PG 10
WC Hematology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Hematology; Cardiovascular System & Cardiology
GA AL6WM
UT WOS:000339274200006
PM 24833795
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Szewczuk, M
   Boguszewska, K
   Kazmierczak-Baranska, J
   Karwowski, BT
AF Szewczuk, Michal
   Boguszewska, Karolina
   Kazmierczak-Baranska, Julia
   Karwowski, Boleslaw T.
TI The role of AMPK in metabolism and its influence on DNA damage repair
SO MOLECULAR BIOLOGY REPORTS
LA English
DT Review
DE AMPK; DNA damage; DNA repair; 8-oxoguanine glycosylase
ID ACTIVATED PROTEIN-KINASE; FATTY-ACID; REACTIVE OXYGEN;
   MITOCHONDRIAL-DNA; OXIDATIVE STRESS; SKELETAL-MUSCLE; AGING PROCESS;
   CAFFEIC ACID; INSULIN; GLUCOSE
AB One of the most complex health disproportions in the human body is the metabolic syndrome (MetS). It can result in serious health consequences such as type 2 diabetes mellitus, atherosclerosis or insulin resistance. The center of energy regulation in human is AMP-activated protein kinase (AMPK), which modulates cells' metabolic pathways and protects them against negative effects of metabolic stress, e.g. reactive oxygen species. Moreover, recent studies show the relationship between the AMPK activity and the regulation of DNA damage repair such as base excision repair (BER) system, which is presented in relation to the influence of MetS on human genome. Hence, AMPK is studied not only in the field of counteracting MetS but also prevention of genetic alterations and cancer development. Through understanding AMPK pathways and its role in cells with damaged DNA it might be possible to improve cell's repair processes and develop new therapies. This review presents AMPK role in eukaryotic cells and focuses on the relationship between AMPK activity and the regulation of BER system through its main component-8-oxoguanine glycosylase (OGG1).
C1 [Szewczuk, Michal; Boguszewska, Karolina; Kazmierczak-Baranska, Julia; Karwowski, Boleslaw T.] Med Univ Lodz, Fac Pharm, DNA Damage Lab Food Sci Dept, Ul Muszynskiego 1, PL-90151 Lodz, Poland.
C3 Medical University Lodz
RP Szewczuk, M; Karwowski, BT (corresponding author), Med Univ Lodz, Fac Pharm, DNA Damage Lab Food Sci Dept, Ul Muszynskiego 1, PL-90151 Lodz, Poland.
EM michal.szewczuk@stud.umed.lodz.pl;
   karolina.boguszewska@stud.umed.lodz.pl;
   julia.kazmierczak-baranska@umed.lodz.pl; boleslaw.karwowski@umed.lodz.pl
RI Karwowski, Boleslaw/S-9232-2016; Kaźmierczak-Barańska,
   Julia/ABD-5419-2020; Boguszewska, Karolina/AAX-6726-2021; Szewczuk,
   Michal/W-2080-2018
OI Kazmierczak-Baranska, Julia/0000-0001-8560-5727; Szewczuk,
   Michal/0000-0002-5680-6594; Karwowski, Boleslaw/0000-0001-6922-7834;
   Boguszewska, Karolina/0000-0003-3772-8540
FU Medical University of Lodz [503/3-045-02/503-31-002]; National Science
   Center, Poland [2016/23/B/NZ7/03367]
FX This research was funded by the Medical University of Lodz (Grant No.
   503/3-045-02/503-31-002) and by the National Science Center, Poland
   (Grant No. 2016/23/B/NZ7/03367).
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NR 104
TC 41
Z9 44
U1 0
U2 14
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0301-4851
EI 1573-4978
J9 MOL BIOL REP
JI Mol. Biol. Rep.
PD NOV
PY 2020
VL 47
IS 11
BP 9075
EP 9086
DI 10.1007/s11033-020-05900-x
EA OCT 2020
PG 12
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA PB8WL
UT WOS:000579320000001
PM 33070285
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Yadav, M
   Parle, M
   Jindal, DK
   Dhingra, S
AF Yadav, Monu
   Parle, Milind
   Jindal, Deepak Kumar
   Dhingra, Sameer
TI Protective effects of stigmasterol against ketamine-induced psychotic
   symptoms: Possible behavioral, biochemical and histopathological changes
   in mice
SO PHARMACOLOGICAL REPORTS
LA English
DT Article
DE Stigmasterol; Ketamine; Psychosis; Phytosterol; Oxidative stress
ID OXIDATIVE STRESS; METABOLIC SYNDROME; SCHIZOPHRENIA; ACID;
   ANTIPSYCHOTICS; PHYTOSTEROLS; SCOPOLAMINE; ESTROGENS; MODEL
AB Background: Stigmasterol, a naturally occurring phytoestrogen has been reported to possess many pharmacological activities. The aim of the present study was to screen the effect of stigmasterol against ketamine-induced mice model of psychosis.
   Methods: The behavioural studies included an assessment of locomotor activity, stereotypic behaviours, immobility duration, step down latency and effects on catalepsy. Biochemical estimations involved the estimations of GABA, dopamine, GSH, MDA, TNF-alpha, total protein content and AChE activity. Histopathological changes and effect on androgenic parameters were also evaluated.
   Results: Stigmasterol treated animals showed significant decrease in locomotor activity, stereotypic behaviours, immobility duration and increased step down latency. Biochemical estimations revealed increased GABA, GSH levels and decreased dopamine, MDA, TNF-alpha levels and AChE activity. These findings were confirmed by histopathological changes in the cortex part of the brain. Further, stigmasterol was not found to cause catalepsy and any adverse effect on the reproductive system.
   Conclusion: This study concluded that stigmasterol could ameliorate ketamine-induced behavioral, biochemical and histopathological alterations in mice showing its potential effects in the management of psychotic symptoms. (c) 2018 Published by Elsevier Sp. z o.o. on behalf of Institute of Pharmacology, Polish Academy of Sciences.
C1 [Yadav, Monu; Parle, Milind; Jindal, Deepak Kumar] Guru Jambheshwar Univ Sci & Technol, Dept Pharmaceut Sci, Fac Med Sci, Hisar, Haryana, India.
   [Dhingra, Sameer] Univ West Indies, Sch Pharm, Fac Med Sci, St Augustine, Trinidad Tobago.
C3 Guru Jambheshwar University of Science & Technology; University West
   Indies Mona Jamaica; University West Indies Saint Augustine
RP Parle, M (corresponding author), Guru Jambheshwar Univ Sci & Technol, Dept Pharmaceut Sci, Fac Med Sci, Hisar, Haryana, India.
EM monuyadav.pharmacology@gmail.com
RI ; Dhingra, Sameer/AFS-2976-2022
OI Yadav, Monu/0000-0002-3003-4186; Dhingra, Sameer/0000-0003-2537-8889
FU Guru Jambheshwar University of Science and Technology, Hisar, Haryana
   (India)
FX The authors are grateful to Guru Jambheshwar University of Science and
   Technology, Hisar, Haryana (India) for financial assistance.
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NR 51
TC 29
Z9 36
U1 0
U2 8
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1734-1140
EI 2299-5684
J9 PHARMACOL REP
JI Pharmacol. Rep.
PD JUN
PY 2018
VL 70
IS 3
BP 591
EP 599
DI 10.1016/j.pharep.2018.01.001
PG 9
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA GL0KP
UT WOS:000436775800026
PM 29679883
DA 2025-06-11
ER

PT J
AU Hatamipour, M
   Johnston, TP
   Sahebkar, A
AF Hatamipour, Mahdi
   Johnston, Thomas P.
   Sahebkar, Amirhossein
TI One Molecule, Many Targets and Numerous Effects: The Pleiotropy of
   Curcumin Lies in its Chemical Structure
SO CURRENT PHARMACEUTICAL DESIGN
LA English
DT Review
DE Curcuminoids; structure-activity relationship; antioxidant; polyphenol;
   immunological disorders; diabetes
ID RADICAL SCAVENGING ABILITY; SYSTEMIC OXIDATIVE STRESS; FATTY
   LIVER-DISEASE; QUALITY-OF-LIFE; DOUBLE-BLIND; BIOLOGICAL-ACTIVITIES;
   PIPERINE COMBINATION; MANGANESE COMPLEXES; METABOLIC SYNDROME; OBESE
   INDIVIDUALS
AB Curcumin quite possibly represents one of the most diverse therapeutic agents yet isolated from natural sources. Therapeutic benefits of this extraordinary natural compound have been demonstrated during treatment of a variety of diseases, including cancer, inflammatory processes, immunological disorders, Diabetes, and oxidative stress often associated with hyperlipidemia. Due to its unique molecular chemical structure and functional groups, curcumin may bind with and subsequently either inhibit or activate a variety of endogenous biomolecules, including enzymes, receptors, signaling molecules, metals, transcription factors, and even certain proteins located in cell membranes. In fact, curcumin exerts pharmacologically useful effects through non-covalent interactions with biomolecules. With so many varied biological targets, curcumin (a polyphenol) elicits numerous pleiotropic effects, which is therapeutically advantageous owing to the fact that many pathological disease states involve more than one signaling pathway, receptor, protein/enzyme, or gene. In this paper, we will discuss the underlying mechanisms responsible for the chemical interaction of curcumin with selected classes of biomolecules, rather than attempt to provide an exhaustive list of each and every biomolecule with which curcumin may chemically interact.
C1 [Hatamipour, Mahdi] Mashhad Univ Med Sci, Nanotechnol Res Ctr, Mashhad, Iran.
   [Johnston, Thomas P.] Univ Missouri Kansas City, Sch Pharm, Div Pharmaceut Sci, Kansas City, MO USA.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Biotechnol Res Ctr, Mashhad, Iran.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Neurogen Inflammat Res Ctr, Mashhad, Iran.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Sch Pharm, Mashhad, Iran.
C3 Mashhad University of Medical Sciences; University of Missouri System;
   University of Missouri Kansas City; Mashhad University of Medical
   Sciences; Mashhad University of Medical Sciences; Mashhad University of
   Medical Sciences
RP Sahebkar, A (corresponding author), Mashhad Univ Med Sci, Sch Med, Dept Med Biotechnol, POB 91779-48564, Mashhad, Iran.
EM sahebkara@mums.ac.ir
RI Sahebkar, Amirhossein/B-5124-2018
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NR 105
TC 34
Z9 35
U1 1
U2 26
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1381-6128
EI 1873-4286
J9 CURR PHARM DESIGN
JI Curr. Pharm. Design
PY 2018
VL 24
IS 19
BP 2129
EP 2136
DI 10.2174/1381612824666180522111036
PG 8
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA GX5BV
UT WOS:000447756500007
PM 29788873
DA 2025-06-11
ER

PT J
AU Collomp, K
   Baillot, A
   Forget, H
   Coquerel, A
   Rieth, N
   Vibarel-Rebot, N
AF Collomp, K.
   Baillot, A.
   Forget, H.
   Coquerel, A.
   Rieth, N.
   Vibarel-Rebot, N.
TI Altered diurnal pattern of steroid hormones in relation to various
   behaviors, external factors and pathologies: A review
SO PHYSIOLOGY & BEHAVIOR
LA English
DT Review
DE Circadian rhythm; Cortisol; DHEA; Testosterone; Behavior; Pathology;
   Physical exercise
ID PITUITARY-ADRENAL AXIS; CORTISOL AWAKENING RESPONSE;
   DEHYDROEPIANDROSTERONE-SULFATE DHEAS; METASTATIC BREAST-CANCER; HEAVY
   RESISTANCE EXERCISE; INTIMA MEDIA THICKNESS; SALIVARY ALPHA-AMYLASE;
   QUALITY-OF-LIFE; SLEEP RESTRICTION; METABOLIC SYNDROME
AB The adrenal and gonadal stress steroids [i.e., cortisol, testosterone and dehydroepiandrosterone (DHEA)] have gathered considerable attention in the last few decades due to their very broad physiological and psychological actions. Their diurnal patterns have become a particular focus following new data implicating altered diurnal hormone patterns in various endocrine, behavioral and cardiovascular risk profiles. In this review of the current literature, we present a brief overview of the altered diurnal patterns of these hormones that may occur in relation to chronic stress, nutritional behaviors, physical exercise, drugs and sleep deprivation/shift. We also present data on the altered diurnal hormone patterns implicated in cardiometabolic and psychiatric/neurologic diseases, cancer and other complex pathologies. We consider the occasionally discrepant results of the studies, and summarize the current knowledge in this new field of interest, underlining the potential effects on both biological and psychological functioning, and assess the implications of these effects. Last, we conclude with some practical considerations and perspectives. (C) 2016 Elsevier Inc. All rights reserved.
C1 [Collomp, K.; Rieth, N.; Vibarel-Rebot, N.] Univ Paris Saclay, Univ Paris 11, CIAMS, F-91405 Orsay, France.
   [Collomp, K.; Rieth, N.; Vibarel-Rebot, N.] Univ Orleans, CIAMS, Allee Chateau, F-45067 Orleans, France.
   [Collomp, K.; Coquerel, A.] Agence Francaise Lutte Dopage, Dept Anal, F-92290 Chatenay Malabry, France.
   [Baillot, A.] Univ Quebec Outaouais, Dept Sci Infirm, Gatineau, PQ, Canada.
   [Baillot, A.] Hop Montfort, Inst Rech, Ottawa, ON, Canada.
   [Forget, H.] Univ Quebec Outaouais, Dept Psychoeduc & Psychol, Gatineau, PQ J8X 3X7, Canada.
   [Coquerel, A.] Univ Caen, INSERM, UMR 1075, F-14032 Caen, France.
C3 Universite Paris Saclay; Universite de Orleans; University of Quebec;
   University Quebec Outaouais; University of Ottawa; University of Quebec;
   University Quebec Outaouais; Institut National de la Sante et de la
   Recherche Medicale (Inserm); Universite de Caen Normandie
RP Collomp, K (corresponding author), Univ Orleans, CIAMS, Allee Chateau, F-45067 Orleans, France.
EM katia.collomp@univ-orleans.fr
OI Collomp, Katia/0000-0001-6004-7052; Vibarel-Rebot,
   Nancy/0000-0001-7795-5786; Baillot, Aurelie/0000-0003-4874-0481
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NR 353
TC 29
Z9 32
U1 0
U2 50
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0031-9384
EI 1873-507X
J9 PHYSIOL BEHAV
JI Physiol. Behav.
PD OCT 1
PY 2016
VL 164
BP 68
EP 85
DI 10.1016/j.physbeh.2016.05.039
PN A
PG 18
WC Psychology, Biological; Behavioral Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Behavioral Sciences
GA DU6QM
UT WOS:000382339700010
PM 27235338
DA 2025-06-11
ER

PT J
AU Kshirsagar, RP
   Kothamasu, MV
   Patil, MA
   Reddy, GB
   Kumar, BD
   Diwan, PV
AF Kshirsagar, Rahul P.
   Kothamasu, Manikanta V.
   Patil, Madhoosudan A.
   Reddy, G. Bhanuprakash
   Kumar, B. Dinesh
   Diwan, Prakash V.
TI Geranium oil ameliorates endothelial dysfunction in high fat high
   sucrose diet induced metabolic complications in rats
SO JOURNAL OF FUNCTIONAL FOODS
LA English
DT Article
DE Geranium oil; High fat high sucrose diet; Endothelial dysfunction;
   Insulin resistance; Dyslipidemia; Oxidative stress
ID REFINED-CARBOHYDRATE DIET; NITRIC-OXIDE SYNTHASE; INSULIN-RESISTANCE;
   SUPEROXIDE ANION; HYPERTENSION; LIVER; DYSLIPIDEMIA; EXPRESSION;
   FRACTIONS; PREVENTS
AB The protective effect of geranium oil (GO) on insulin resistance, dyslipidemia, endothelial dysfunction and associated cardiovascular changes in rats fed with high fat sucrose (HFS) diet was evaluated. HFS diet (20% fat and 30% sucrose) was fed to wistar rats for 12 weeks to induce metabolic complications and treated with different doses of GO (100, 200 and 400 mg/kg p.o.) for the last 6 weeks. Prolonged administration of HFS diet led to metabolic syndrome characterized by significant increase in plasma glucose, insulin, insulin resistance, triacylglycerol (TG), total cholesterol (TC), low density lipoprotein (LDL) along with decreased high density lipoprotein (HDL), serum nitric oxide (NO) levels and impaired glucose tolerance. Furthermore HFS diet resulted in significant increase in mean arterial pressure, electrocardiographic changes and reduced acetylcholine induced endothelial dependent relaxation of rat aorta along with elevated oxidative stress (reduced superoxide dismutase, catalase, glutathione S transferase and increased TBARS level). Treatment with GO positively modulated the altered parameters in dose dependent manner suggesting overall beneficial effects of GO on HFS diet associated detrimental changes. (C) 2015 Elsevier Ltd. All rights reserved.
C1 [Kshirsagar, Rahul P.; Kothamasu, Manikanta V.; Diwan, Prakash V.] Anurag Grp Inst, Sch Pharm, Dept Pharmacol, Hyderabad 500088, Telangana, India.
   [Patil, Madhoosudan A.; Reddy, G. Bhanuprakash] Natl Inst Nutr ICMR, Dept Biochem, Hyderabad 500007, Telangana, India.
   [Kumar, B. Dinesh] Natl Inst Nutr ICMR, Food & Drug Toxicol Res Ctr, Hyderabad 500007, Telangana, India.
C3 Indian Council of Medical Research (ICMR); ICMR - National Institute of
   Nutrition (NIN); Indian Council of Medical Research (ICMR); ICMR -
   National Institute of Nutrition (NIN)
RP Diwan, PV (corresponding author), Anurag Grp Inst, Sch Pharm, Hyderabad 500088, Telangana, India.
EM diwanpv@gmail.com
RI Patil, Madhoosudan/Y-9859-2019; Reddy, G. Bhanuprakash/AAJ-3494-2020
OI Reddy, G. Bhanuprakash/0000-0003-4787-3944; Kshirsagar,
   Rahul/0000-0001-5917-3326; Patil, Madhoosudan/0000-0002-1586-2792;
   Diwan, Prakash/0000-0001-5331-3615
CR Atta-ur-Rahman, 2001, BIOACTIVE NATURAL F
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NR 43
TC 7
Z9 8
U1 0
U2 6
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1756-4646
J9 J FUNCT FOODS
JI J. Funct. Food.
PD MAY
PY 2015
VL 15
BP 284
EP 293
DI 10.1016/j.jff.2015.03.029
PG 10
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA CJ1JV
UT WOS:000355240800028
DA 2025-06-11
ER

PT J
AU Li, H
   Zhou, Y
   Zhao, A
   Qiu, Y
   Xie, G
   Jiang, Q
   Zheng, X
   Zhong, W
   Sun, X
   Zhou, Z
   Jia, W
AF Li, H.
   Zhou, Y.
   Zhao, A.
   Qiu, Y.
   Xie, G.
   Jiang, Q.
   Zheng, X.
   Zhong, W.
   Sun, X.
   Zhou, Z.
   Jia, W.
TI Asymmetric dimethylarginine attenuates serum starvation-induced
   apoptosis via suppression of the Fas (APO-1/CD95)/JNK (SAPK) pathway
SO CELL DEATH & DISEASE
LA English
DT Article
DE ADMA; colon cancer; apoptosis; Fas; JNK; chemotherapy
ID ENDOTHELIAL DYSFUNCTION; METABOLIC SYNDROME; SIGNALING PATHWAY; PASSAGE
   NUMBER; RISK-FACTOR; IN-VITRO; CELLS; CERAMIDE; CANCER; METFORMIN
AB Asymmetric dimethylarginine (ADMA) is synthesized by protein arginine methyltransferases during methylation of protein arginine residues and released into blood upon proteolysis. Higher concentrations of ADMA in blood have been observed in patients with metabolic diseases and certain cancers. However, the role of ADMA in colon cancer has not been well investigated. ADMA serum levels in human patients diagnosed with colon cancer were found to be higher than those present in healthy subjects. ADMA treatment of LoVo cells, a human colon adenocarcinoma cell line, attenuated serum starvation-induced apoptosis and suppressed the activation of the Fas (APO-1/CD95)/JNK (SAPK) (c-Jun N terminal protein kinase/stress-activated protein kinase) pathway. ADMA also suppressed the activation of JNK triggered by death receptor ligand anti-Fas mAb and exogenous C-2-ceramide. Moreover, we demonstrated that ADMA pretreatment protected LoVo cells from doxorubicin hydrochloride-induced cell death and activation of the Fas/JNK pathway. In summary, our results suggest that the elevated ADMA in colon cancer patients may contribute to the blocking of apoptosis of cancer cells in response to stress and chemotherapy.
C1 [Li, H.; Zhao, A.; Zheng, X.; Jia, W.] Shanghai Jiao Tong Univ, Ctr Translat Med, Affiliated Peoples Hosp 6, Shanghai 200233, Peoples R China.
   [Li, H.; Zhou, Y.; Qiu, Y.; Xie, G.; Zhong, W.; Sun, X.; Zhou, Z.] Univ North Carolina Greensboro, Ctr Translat Biomed Res, Kannapolis, NC 28081 USA.
   [Jiang, Q.] David H Murdock Res Inst, Kannapolis, NC 28081 USA.
   [Jia, W.] Univ Hawaii, Ctr Canc, Honolulu, HI 96813 USA.
C3 Shanghai Jiao Tong University; University of North Carolina; University
   of North Carolina Greensboro; University of Hawaii System; Cancer
   Research Center of Hawaii
RP Jia, W (corresponding author), Univ Hawaii, Ctr Canc, 701 Ilalo St, Honolulu, HI 96813 USA.
EM wjia@cc.hawaii.edu
RI Jia, Wei/AAN-5102-2020; Xie, Guoxiang/F-3022-2016; Qiu,
   Yunping/AAO-5200-2021
OI Jia, Wei/0000-0002-3739-8994; Qiu, Yunping/0000-0003-1039-5264; Xie,
   Guoxiang/0000-0002-0951-4150
FU National Institutes of Health [R01AA020212]
FX This work was supported in part by National Institutes of Health Grant
   R01AA020212.
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NR 57
TC 20
Z9 20
U1 0
U2 8
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 2041-4889
J9 CELL DEATH DIS
JI Cell Death Dis.
PD OCT
PY 2013
VL 4
AR e830
DI 10.1038/cddis.2013.345
PG 8
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA 251XK
UT WOS:000326967100016
PM 24091673
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Treiber, K
   Carter, R
   Gay, L
   Williams, C
   Geor, R
AF Treiber, Kibby
   Carter, Rebecca
   Gay, Louisa
   Williams, Carey
   Geor, Ray
TI Inflammatory and redox status of ponies with a history of
   pasture-associated laminitis
SO VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY
LA English
DT Article
DE Laminitis; Inflammation; Oxidative stress; Tumor necrosis factor-alpha
ID OXIDATIVE STRESS; INSULIN-RESISTANCE; OBESITY; DYSFUNCTION; EXPRESSION;
   STAGE
AB Inflammatory and redox signals could render lamellar tissue susceptible to damage and contribute to higher risk for laminitis in obese or insulin resistant ponies just as these factors contribute to health risks in humans with metabolic syndrome. This study evaluated circulating markers of inflammatory and redox status in ponies that had a history of recurrent bouts of pasture-associated laminitis (PL, n = 42) or had never developed clinical laminitis (NL, n = 34) under the current management conditions. There were no differences (P > 0.05) between PL and NL ponies for markers of antioxidant function (glutathione, glutathione peroxidase, superoxide dismutase) or increased oxidative pressure (malondialdehyde, apoptosis, 3-nitrotyrosine). Inflammatory status, as indicated by fibrinogen concentration, was also not different between pony groups (P = 0.84). However, PL ponies had higher (P < 0.001) plasma concentrations of the pro-inflammatory cytokine TNF-alpha than NL ponies. This suggests that a predisposition to laminitis is associated with increased circulating inflammatory cytokines. TNF-alpha could also represent a contributing factor to increased insulin resistance observed in laminitis prone ponies. These results provide new insight into potential mechanisms and risk factors underlying laminitis. (C) 2008 Elsevier B.V. All rights reserved.
C1 [Treiber, Kibby; Carter, Rebecca; Gay, Louisa; Geor, Ray] Middleburg Agr Res & Extens Center, Middleburg, VA 20117 USA.
   [Treiber, Kibby; Carter, Rebecca; Gay, Louisa; Geor, Ray] Virginia Polytech Inst & State Univ, Dept Anim & Poultry Sci, Blacksburg, VA 24061 USA.
   [Williams, Carey] Rutgers State Univ, Dept Anim Sci, New Brunswick, NJ 08901 USA.
C3 Virginia Polytechnic Institute & State University; Rutgers University
   System; Rutgers University New Brunswick
RP Treiber, K (corresponding author), Middleburg Agr Res & Extens Center, 5527 Sullivans Mill Rd, Middleburg, VA 20117 USA.
EM ktreiber@vt.edu
RI Geor, Raymond/P-4631-2017
OI Geor, Raymond/0000-0002-6825-6737
FU Virginia Horse Industry Board
FX This study was supported by Virginia Horse Industry Board. Special
   thanks to Dr. Craig Thatcher for technical assistance.
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TC 59
Z9 72
U1 1
U2 13
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-2427
EI 1873-2534
J9 VET IMMUNOL IMMUNOP
JI Vet. Immunol. Immunopathol.
PD JUN 15
PY 2009
VL 129
IS 3-4
SI SI
BP 216
EP 220
DI 10.1016/j.vetimm.2008.11.004
PG 5
WC Immunology; Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Veterinary Sciences
GA 446JU
UT WOS:000266118700013
PM 19108899
DA 2025-06-11
ER

PT J
AU Aggarwal, K
   Bansal, V
   Mahmood, R
   Kanagala, SG
   Jain, R
AF Aggarwal, Kanishk
   Bansal, Vasu
   Mahmood, Ramsha
   Kanagala, Sai Gautham
   Jain, Rohit
TI Asthma and Cardiovascular Diseases: Uncovering Common Ground in Risk
   Factors and Pathogenesis
SO CARDIOLOGY IN REVIEW
LA English
DT Review
DE asthma; atrial fibrillation; cardiovascular disease; obesity
ID CORONARY-HEART-DISEASE; MAST-CELLS; GENOMEWIDE ASSOCIATION; ARTERIAL
   STIFFNESS; ORMDL3 EXPRESSION; INFLAMMATION; OBESITY; GLUCOCORTICOIDS;
   SUSCEPTIBILITY; HYPERTENSION
AB Asthma and cardiovascular diseases (CVDs) are the 2 common and complex health problems with a substantial global impact. Epidemiological studies indicate that asthma and CVDs are common, with evidence supporting their cooccurrence. Inflammation, oxidative stress, obesity, metabolic syndrome, smoking, secondhand smoke exposure, physical inactivity, and environmental exposures are all risk factors for asthma and CVDs. In addition, inflammatory and immunological pathways, autonomic dysfunction, endothelial dysfunction, thrombosis, coagulation, and common genetic risk factors contribute to the asthma-CVD relationship. Asthmatic individuals have higher morbidity and mortality rates related to CVDs and high-risk factors. Techniques such as screening for CVDs in asthma patients, pharmaceutical therapy, and lifestyle changes are critical for effectively managing these comorbid illnesses. Understanding the link between asthma and CVD is necessary for integrated and clinical management approaches to enhance patient outcomes and lessen the burden of these related diseases.
C1 [Aggarwal, Kanishk; Bansal, Vasu] Dayanand Med Coll & Hosp, Ludhiana, India.
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   [Kanagala, Sai Gautham] Osmania Med Coll & Hosp, Hyderabad, India.
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C3 Dayanand Medical College & Hospital; Pennsylvania Commonwealth System of
   Higher Education (PCSHE); Pennsylvania State University; Penn State
   Health
RP Mahmood, R (corresponding author), 59 Cinrickbar Dr, Toronto, ON M9W 6X3, Canada.
EM ramsha.m9418@gmail.com
RI Aggarwal, Kanishk/MBV-6086-2025
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PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1061-5377
EI 1538-4683
J9 CARDIOL REV
JI Cardiol. Rev.
PD MAY-JUN
PY 2025
VL 33
IS 3
BP 219
EP 226
DI 10.1097/CRD.0000000000000600
PG 8
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 0YY6R
UT WOS:001459351500009
PM 37594265
DA 2025-06-11
ER

PT J
AU Yang, HW
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   Li, X
   Jeon, YJ
   Ryu, B
AF Yang, Hye-Won
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   Jeon, You-Jin
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TI Anti-Obesity and Anti-Diabetic Effects of Ishige okamurae
SO MARINE DRUGS
LA English
DT Review
DE Ishige okamurae; marine alga; obesity; diabetes; nutraceuticals
ID RADICAL SCAVENGING ACTIVITY; INDUCED INSULIN-RESISTANCE; INDUCED
   OXIDATIVE STRESS; NF-KAPPA-B; ALPHA-GLUCOSIDASE; BROWN ALGA; BIOACTIVE
   COMPOUNDS; CELL-PROLIFERATION; ENERGY-EXPENDITURE; LIPID-PEROXIDATION
AB Obesity is associated with several health complications and can lead to the development of metabolic syndrome. Some of its deleterious consequences are related to insulin resistance, which adversely affects blood glucose regulation. At present, there is a growing concern regarding healthy food consumption, owing to awareness about obesity. Seaweeds are well-known for their nutritional benefits. The brown alga Ishige okamurae (IO) has been studied as a dietary supplement and exhibits various biological activities in vitro and in vivo. The bioactive compounds isolated from IO extract are known to possess anti-obesity and anti-diabetic properties, elicited via the regulation of lipid metabolism and glucose homeostasis. This review focuses on IO extract and its bioactive compounds that exhibit therapeutic effects through several cellular mechanisms in obesity and diabetes. The information discussed in the present review may provide evidence to develop nutraceuticals from IO.
C1 [Yang, Hye-Won; Fernando, K. H. N.; Oh, Jae-Young; Li, Xining; Jeon, You-Jin; Ryu, BoMi] Jeju Natl Univ, Dept Marine Life Sci, Jeju 63243, South Korea.
C3 Jeju National University
RP Jeon, YJ; Ryu, B (corresponding author), Jeju Natl Univ, Dept Marine Life Sci, Jeju 63243, South Korea.
EM koty221@naver.com; hiruninfdo@gmail.com; ojy0724@naver.com;
   xiningmarinesci666@naver.com; youjin2014@gmail.com; ryu.bomi@gmail.com
RI Jeon, You-Jin/AAR-5061-2020; Ryu, Bomi/H-5795-2019
OI Ryu, Bomi/0000-0001-5797-500X; Jeon, You-Jin/0000-0003-3299-7266
FU Ministry of Oceans and Fisheries, Korea
FX : This research was a part of the project titled 'Development of
   functional food products with natural materials derived from marine
   resources', funded by the Ministry of Oceans and Fisheries, Korea.
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NR 88
TC 22
Z9 24
U1 1
U2 14
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1660-3397
J9 MAR DRUGS
JI Mar. Drugs
PD APR
PY 2019
VL 17
IS 4
AR 202
DI 10.3390/md17040202
PG 11
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA HX3QM
UT WOS:000467307100009
PM 30934943
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Watroba, M
   Maslinska, D
   Maslinski, S
AF Watroba, M.
   Maslinska, D.
   Maslinski, S.
TI Current overview of functions of FoxO proteins, with special regards to
   cellular homeostasis, cell response to stress, as well as inflammation
   and aging
SO ADVANCES IN MEDICAL SCIENCES
LA English
DT Review
DE FoxO; cellular homeostasis; inflammation; aging; degeneration;
   carcinogenesis
ID TRANSCRIPTION FACTORS INDUCE; KAPPA-B-KINASE; FORKHEAD TRANSCRIPTION;
   METABOLIC SYNDROME; SIGNALING PATHWAY; TUMOR SUPPRESSION;
   ADIPOSE-TISSUE; PHOSPHORYLATION; EXPRESSION; MECHANISM
AB FoxO transcription factors act at the interconnections between metabolic pathways inducible by many important signal transducers and mediators, such as p53, Ikk-beta, NFKB, Akt, sirtuins, PTEN, and others. This may account for a crucial significance of disruptions in FoxO functions both in many kinds of diseases (including cancer, chronic inflammatory diseases, degenerative diseases, obesity, polymetabolic syndrome) and in some disease-like conditions (such as inflammaging, cachexia related to chronic inflammation, cancer-promotion by some chronic inflammatory responses, and the aging process itself). This paper reviews complex interactions between FoxOs and other signal transducers, trying to pinpoint how exactly disruptions of FoxO functions may occur, and how they may contribute to occurrence, development or complications of the conditions mentioned above.
C1 [Watroba, M.; Maslinska, D.; Maslinski, S.] Med Univ Warsaw, Dept Pathophysiol, Warsaw, Poland.
   [Maslinska, D.] Polish Acad Sci, Mossakowski Med Res Ctr, Dept Neuropathol, Warsaw, Poland.
   [Maslinski, S.] Inst Rheumatol, Dept Biochem, Warsaw, Poland.
C3 Medical University of Warsaw; Polish Academy of Sciences; Mossakowski
   Medical Research Institute of the Polish Academy of Sciences
RP Watroba, M (corresponding author), Med Univ Warsaw, Dept Pathophysiol, Zwirki & Wigury 61, Warsaw, Poland.
EM matpat71@yahoo.com
OI Watroba, Mateusz/0000-0003-4077-3641
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NR 91
TC 24
Z9 30
U1 2
U2 27
PU MEDICAL UNIV BIALYSTOK
PI BIALYSTOK
PA UL KILINSKIEGO 1, BIALYSTOK, 15-089, POLAND
SN 1896-1126
EI 1898-4002
J9 ADV MED SCI-POLAND
JI Adv. Med. Sci.
PD DEC
PY 2012
VL 57
IS 2
BP 183
EP 195
DI 10.2478/v10039-012-0039-1
PG 13
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 139DO
UT WOS:000318562000002
PM 23183765
DA 2025-06-11
ER

PT J
AU Charles, LE
   Burchfiel, CM
   Mnatsakanova, A
   Fekedulegn, D
   Tinney-Zara, C
   Joseph, PN
   Schunemann, HJ
   Violanti, JM
   Andrew, ME
   Ochs-Balcom, HM
AF Charles, Luenda E.
   Burchfiel, Cecil M.
   Mnatsakanova, Anna
   Fekedulegn, Desta
   Tinney-Zara, Cathy
   Joseph, P. Nedra
   Schunemann, Holger J.
   Violanti, John M.
   Andrew, Michael E.
   Ochs-Balcom, Heather M.
TI Antioxidants and Pulmonary Function Among Police Officers
SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
LA English
DT Article
ID C-REACTIVE PROTEIN; LUNG-FUNCTION; METABOLIC SYNDROME; OXIDATIVE STRESS;
   DIETARY-INTAKE; RESPIRATORY SYMPTOMS; WORK HOURS; MORTALITY; POPULATION;
   HEALTH
AB Objective: To examine associations of dietary antioxidant intake and pulmonary function. Methods: Antioxidant data (vitamins A, C, D, E, magnesium, and omega-3 fatty acids) were abstracted from food frequency questionnaires. Pulmonary function was measured using American Thoracic Society criteria. We used analysis of variance to investigate associations. Results: Among 79 police officers (57% male), forced vital capacity was positively and significantly associated with vitamin A after adjustment for age, gender, height, race, smoking status, and pack-years of smoking, and with magnesium after adjustment for those risk factors plus total calories, all supplement use, and abdominal height. Among current/former smokers only, mean levels of all pulmonary function measures were significantly associated with vitamin E; smoking status significantly modified these relationships. Conclusions: Increased intake of vitamin A, vitamin E (among current/former smokers only), and magnesium was associated with better pulmonary function.
C1 [Charles, Luenda E.] NIOSH, HELD BEB, Biostat & Epidemiol Branch, Hlth Effects Lab Div,Ctr Dis Control & Prevent, Morgantown, WV 26505 USA.
   [Schunemann, Holger J.] McMaster Univ, Dept Clin Epidemiol & Biostat, Hamilton, ON, Canada.
   [Schunemann, Holger J.] McMaster Univ, Dept Med, Hamilton, ON, Canada.
   [Violanti, John M.; Ochs-Balcom, Heather M.] SUNY Buffalo, Dept Social & Prevent Med, Sch Publ Hlth & Hlth Profess, Buffalo, NY 14260 USA.
C3 Centers for Disease Control & Prevention - USA; National Institute for
   Occupational Safety & Health (NIOSH); McMaster University; McMaster
   University; State University of New York (SUNY) System; University at
   Buffalo, SUNY
RP Charles, LE (corresponding author), NIOSH, HELD BEB, Biostat & Epidemiol Branch, Hlth Effects Lab Div,Ctr Dis Control & Prevent, MailStop L-4050,1095 Willowdale Rd, Morgantown, WV 26505 USA.
EM lcharles@cdc.gov
RI Ochs-Balcom, Heather/F-3500-2012; Charles, Luenda/H-6008-2011;
   Schunemann, Holger/LRB-7016-2024
OI Tinney-Zara, Cathy/0000-0002-6529-9619; Schunemann,
   Holger/0000-0003-3211-8479; Joseph, Parveen/0000-0001-5635-085X
FU National Institute for Occupational Safety and Health [1RO3OH003772-01]
FX This research was supported by the National Institute for Occupational
   Safety and Health (1RO3OH003772-01). The findings and conclusions in
   this article are those of the authors and do not necessarily represent
   the views of the National Institute for Occupational Safety and Health.
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NR 61
TC 2
Z9 3
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1076-2752
EI 1536-5948
J9 J OCCUP ENVIRON MED
JI J. Occup. Environ. Med.
PD NOV
PY 2010
VL 52
IS 11
BP 1124
EP 1131
DI 10.1097/JOM.0b013e3181f7cb4c
PG 8
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA 678GD
UT WOS:000284061200010
PM 21063191
DA 2025-06-11
ER

PT J
AU Miyata, Y
   Fukuhara, A
   Matsuda, M
   Komuro, R
   Shimomura, I
AF Miyata, Yugo
   Fukuhara, Atsunori
   Matsuda, Morihiro
   Komuro, Ryutaro
   Shimomura, Iichiro
TI Insulin induces chaperone and CHOP gene expressions in adipocytes
SO BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
LA English
DT Article
DE chaperone; adipocyte; insulin; endoplasmic reticulum; CHOP
ID ENDOPLASMIC-RETICULUM STRESS; ADIPOSE-TISSUE; REGULATES EXPRESSION;
   METABOLIC SYNDROME; 3T3-L1 ADIPOCYTES; PROTEIN-SYNTHESIS; CELLS;
   APOPTOSIS; GRP78; INHIBITION
AB Adipocyte secretes bioactive proteins called adipocytokines, and biosynthesis of secretory proteins requires molecular chaperones and folding enzymes in endoplasmic reticulum (ER). ER chaperones are known to be induced by unfolded protein response (UPR) and growth factors. however. it has not been determined how ER chaperones expression is regulated in adipocytes. Here we show that insulin treatment induced GRP78 and ERO1L mRNA levels in 3T3-L1 adipocytes. Insulin also upregulated CHOP mRNA levels, but did not induce phosphorylation of eIF2 alpha. Pretreatment with insulin protected 3T3-L1 adipocytes against thapsigargin-mediated phosphorylation of eIF2 alpha but did not against DTT-mediated one. In vivo mice study showed that GRP78 and CHOP expressions were regulated by feeding conditions. These results suggest that insulin signaling is important to induce mRNA expressions of GRP78 and CHOP, and may have a protective role against UPR. (C) 2007 Elsevier Inc. All rights reserved.
C1 [Miyata, Yugo; Fukuhara, Atsunori; Matsuda, Morihiro; Komuro, Ryutaro; Shimomura, Iichiro] Osaka Univ, Grad Sch Med, Dept Metab Med, Suita, Osaka 5650871, Japan.
C3 The University of Osaka
RP Fukuhara, A (corresponding author), Osaka Univ, Grad Sch Med, Dept Metab Med, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan.
EM afukuhara-circ@umin.ac.jp
RI ; Fukuhara, Atsunori/A-9601-2018
OI Miyata, Yugo/0000-0002-3245-4600; Fukuhara, Atsunori/0000-0002-6289-3778
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NR 33
TC 11
Z9 12
U1 0
U2 7
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0006-291X
J9 BIOCHEM BIOPH RES CO
JI Biochem. Biophys. Res. Commun.
PD JAN 25
PY 2008
VL 365
IS 4
BP 826
EP 832
DI 10.1016/j.bbrc.2007.11.045
PG 7
WC Biochemistry & Molecular Biology; Biophysics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics
GA 244LJ
UT WOS:000251867100036
PM 18035047
DA 2025-06-11
ER

PT J
AU Miceli, C
   Leri, M
   Stefani, M
   Bucciantini, M
AF Miceli, Caterina
   Leri, Manuela
   Stefani, Massimo
   Bucciantini, Monica
TI Autophagy-related proteins: Potential diagnostic and prognostic
   biomarkers of aging-related diseases
SO AGEING RESEARCH REVIEWS
LA English
DT Review
DE Aging; Autophagy; Biomarkers; Aging-diseases; Clinical practice
ID CHAPERONE-MEDIATED AUTOPHAGY; AMYOTROPHIC-LATERAL-SCLEROSIS; MOUSE
   MODEL; CELL-DEATH; ALPHA-SYNUCLEIN; THERAPEUTIC TARGET; METABOLIC
   SYNDROME; OXIDATIVE STRESS; LIFE-SPAN; MITOCHONDRIAL DYSFUNCTION
AB Autophagy plays a key role in cellular, tissue and organismal homeostasis and in the production of the energy load needed at critical times during development and in response to nutrient shortage. Autophagy is generally considered as a pro-survival mechanism, although its deregulation has been linked to non-apoptotic cell death. Autophagy efficiency declines with age, thus contributing to many different pathophysiological conditions, such as cancer, cardiomyopathy, diabetes, liver disease, autoimmune diseases, infections, and neurodegeneration. Accordingly, it has been proposed that the maintenance of a proper autophagic activity contributes to the extension of the lifespan in different organisms. A better understanding of the interplay between autophagy and risk of age-related pathologies is important to propose nutritional and life-style habits favouring disease pre-vention as well as possible clinical applications aimed at promoting long-term health.
C1 [Miceli, Caterina] Telethon Inst Genet & Med TIGEM, Naples, Italy.
   [Leri, Manuela; Stefani, Massimo; Bucciantini, Monica] Univ Florence, Dept Expt Clin & Biomed Sci, Florence, Italy.
C3 Fondazione Telethon; Telethon Institute of Genetics & Medicine (TIGEM);
   University of Florence
RP Bucciantini, M (corresponding author), Univ Florence, Dept Expt Clin & Biomed Sci, Florence, Italy.
EM monica.bucciantini@unifi.it
RI MICELI, CATERINA/LBH-5335-2024; Leri, Manuela/M-8431-2019
FU Fondazione Umberto Veronesi
FX <B>Acknowledgements</B> ML was supported by Fondazione Umberto Veronesi.
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NR 264
TC 17
Z9 17
U1 2
U2 26
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 1568-1637
EI 1872-9649
J9 AGEING RES REV
JI Ageing Res. Rev.
PD AUG
PY 2023
VL 89
AR 101967
DI 10.1016/j.arr.2023.101967
EA JUN 2023
PG 18
WC Cell Biology; Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Geriatrics & Gerontology
GA P8QV2
UT WOS:001053270300001
PM 37270146
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Gugliucci, A
   Caccavello, R
AF Gugliucci, Alejandro
   Caccavello, Russell
TI Optimized sensitive and inexpensive method to measure D-lactate as a
   surrogate marker of methylglyoxal fluxes in metabolically relevant
   contexts
SO METHODS
LA English
DT Article
DE Obesity; Metabolic syndrome; Methylglyoxal; D-lactate; Atherosclerosis;
   Insulin-resistance
ID GLYCATION END-PRODUCTS; DICARBONYL STRESS; GLYOXALASE; PLASMA; ASSAY
AB Introduction: Plasma D-lactate levels can be considered a surrogate indicator of MG flux. There are commercial methods specifically designed to cover pathological ranges (mmol/l in sepsis or leaky gut) that are not suitable to encompass the metabolically relevant ranges.
   Material and methods: We modified and optimized the D-lactate Colorimetric Assay kit MAK058 from Sigma adding an ultracentrifugation step, kinetic reading and increasing reaction temperature.
   Results and conclusions: We present a modified, optimized and validated method to measure serum D-lactate using a commercial kit to increase the sensitivity of the method to 2 orders of magnitude lower as well as minimizing interferences so that it may be used by researchers to explore the D-lactate pathway in metabolic disorders at a low cost (colorimetric method and a plate reader) and with a much higher specificity.
C1 [Gugliucci, Alejandro; Caccavello, Russell] Touro Univ Calif, Coll Osteopath Med, Dept Res, Glycat Oxidat & Dis Lab, Vallejo, CA USA.
C3 Touro University California
RP Gugliucci, A (corresponding author), Touro Univ Calif, 1310 Club Dr, Vallejo, CA 94592 USA.
EM alejandro.gugliucci@tu.edu
FU Touro University-California [069]
FX Touro University-California (069).
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NR 23
TC 6
Z9 6
U1 0
U2 3
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 1046-2023
EI 1095-9130
J9 METHODS
JI Methods
PD JUL
PY 2022
VL 203
BP 5
EP 9
DI 10.1016/j.ymeth.2020.06.010
EA MAY 2022
PG 5
WC Biochemical Research Methods; Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 5E9LE
UT WOS:000865941900002
PM 32590035
DA 2025-06-11
ER

PT J
AU Jiang, S
   Xiao, HX
   Wu, Z
   Yang, Z
   Ding, BP
   Jin, ZX
   Yang, Y
AF Jiang Shuai
   Xiao Haoxiang
   Wu Zhen
   Yang Zhi
   Ding Baoping
   Jin Zhenxiao
   Yang Yang
TI NLRP3 sparks the Greek fire in the war against lipid-related diseases
SO OBESITY REVIEWS
LA English
DT Article
DE atherosclerosis; lipid-related diseases; liver diseases; NLRP3
   inflammasome; obesity; type 2 diabetes
ID NF-KAPPA-B; HIGH-FAT DIET; INFLAMMASOME ACTIVATION; OXIDATIVE STRESS;
   ALCOHOLIC STEATOHEPATITIS; NALP3 INFLAMMASOME; METABOLIC SYNDROME; HIGH
   GLUCOSE; OBESITY; ATHEROSCLEROSIS
AB In recent years, the obesity rate worldwide has reached epidemic proportions and contributed to the growing prevalence of lipid-related diseases. A strong link between inflammation and metabolism is becoming increasingly evident. Compelling evidence has indicated the activation of the nucleotide-binding and oligomerization domain-like receptor, leucine-rich repeat and pyrin domain-containing 3 (NLRP3) inflammasome, a cytoplasmic complex containing multiple proteins, in a variety of lipid-related diseases including obesity, atherosclerosis, liver diseases, and type 2 diabetes. Recent studies have further clarified the regulatory mechanisms and the optional therapeutic agents that target NLRP3 inflammasomes. In this study, we review the recent progress in the research on NLRP3 inflammasomes and discuss their implications for a better understanding of inflammation in lipid-related disease and the prospects of targeting the NLRP3 inflammasome for therapeutic intervention.
C1 [Jiang Shuai; Wu Zhen; Yang Zhi; Ding Baoping; Yang Yang] Northwest Univ, Key Lab Resource Biol & Biotechnol Western China, Minist Educ, Life Sci, Xian, Peoples R China.
   [Xiao Haoxiang; Jin Zhenxiao] Fourth Mil Med Univ, Xijing Hosp, Dept Cardiovasc Surg, Xian, Peoples R China.
C3 Ministry of Education - China; Northwest University Xi'an; Air Force
   Medical University
RP Jin, ZX; Yang, Y (corresponding author), Northwest Univ, Key Lab Resource Biol & Biotechnol Western China, Minist Educ, Fac Life Sci, 229 Taibai North Rd, Xian 710069, Peoples R China.
EM zhenxiaojin210@126.com; yang200214yy@163.com
RI Jin, Zhenxiao/AAJ-5777-2020
OI Yang, Yang/0000-0002-1163-2359; Jin, Zhenxiao/0000-0003-0586-816X
FU Natural Science Foundation of Shaanxi Province [2018JM3042]; National
   Natural Science Foundation of China [81600306, 81700236, 81871607]
FX Natural Science Foundation of Shaanxi Province, Grant/Award Number:
   2018JM3042; National Natural Science Foundation of China, Grant/Award
   Numbers: 81600306, 81700236, 81871607
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NR 131
TC 6
Z9 7
U1 0
U2 8
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1467-7881
EI 1467-789X
J9 OBES REV
JI Obes. Rev.
PD SEP
PY 2020
VL 21
IS 9
DI 10.1111/obr.13045
EA MAY 2020
PG 13
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA MZ4LD
UT WOS:000531290500001
PM 32390276
DA 2025-06-11
ER

PT J
AU Regenboog, M
   van Kuilenburg, ABP
   Verheij, J
   Swinkels, DW
   Hollak, CEM
AF Regenboog, Martine
   van Kuilenburg, Andre B. P.
   Verheij, Joanne
   Swinkels, Dorine W.
   Hollak, Carla E. M.
TI Hyperferritinemia and iron metabolism in Gaucher disease: Potential
   pathophysiological implications
SO BLOOD REVIEWS
LA English
DT Review
DE Gaucher disease; Iron metabolism; Ferritin; Hepcidin; Carcinogenesis
ID ENZYME REPLACEMENT THERAPY; OF-THE-LITERATURE; STILLS-DISEASE;
   PARKINSONS-DISEASE; OXIDATIVE STRESS; SYSTEMS BIOLOGY; SERUM FERRITIN;
   TYPE-1; CELLS; PLASMA
AB Gaucher disease (GD) is characterized by large amounts of lipid-storing macrophages and is associated with accumulation of iron. High levels of ferritin are a hallmark of the disease. The precise mechanism underlying the changes in iron metabolism has not been elucidated. A systematic search was conducted to summarize available evidence from the literature on iron metabolism in GD and its potential pathophysiological implications. We conclude that in GD, a chronic low grade inflammation state can lead to high ferritin levels and increased hepcidin transcription with subsequent trapping of ferritin in macrophages. Extensive GD manifestations with severe anemia or extreme splenomegaly can lead to a situation of iron-overload resembling hemo-chromatosis. We hypothesize that specifically this latter situation carries a risk for the occurrence of associated conditions such as the increased cancer risk, metabolic syndrome and neurodegeneration. (C) 2016 Elsevier Ltd. All rights reserved.
C1 [Regenboog, Martine; Hollak, Carla E. M.] Acad Med Ctr Amsterdam, Dept Internal Med, Div Endocrinol & Metab, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands.
   [van Kuilenburg, Andre B. P.] Acad Med Ctr Amsterdam, Lab Genet Metab Dis, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands.
   [Verheij, Joanne] Acad Med Ctr Amsterdam, Dept Pathol, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands.
   [Swinkels, Dorine W.] Radboud Univ Nijmegen, Med Ctr, Translat Metab Lab, Dept Lab Med, Nijmegen, Netherlands.
C3 University of Amsterdam; Academic Medical Center Amsterdam; University
   of Amsterdam; Academic Medical Center Amsterdam; University of
   Amsterdam; Academic Medical Center Amsterdam; Radboud University
   Nijmegen
RP Regenboog, M (corresponding author), Acad Med Ctr Amsterdam, Dept Internal Med, Div Endocrinol & Metab, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands.
EM m.regenboog@amc.uva.nl; a.b.vankuilenburg@amc.uva.nl;
   j.verheij@amc.uva.nl; dorine.swinkels@radboudumc.nl;
   c.e.hollak@amc.uva.nl
RI van Kuilenburg, Andre/KVC-2335-2024; Swinkels, Dorine/H-8098-2014
OI van Kuilenburg, Andre/0000-0002-7989-4910; Verheij,
   Joanne/0000-0003-1283-630X; Hollak, Carla/0000-0003-0464-1078
FU Genzyme; Shire
FX The authors MR, ABPvK, JV and DWS declare no conflict of interest. CEMH
   declares that over the last 3 years, she has received reimbursement of
   travel and accommodation for serving at Shire's charitable program. The
   Academic Medical Center has received educational and research grants
   from Genzyme and Shire and receives support for Registries.
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NR 89
TC 21
Z9 21
U1 2
U2 8
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0268-960X
EI 1532-1681
J9 BLOOD REV
JI Blood Rev.
PD NOV
PY 2016
VL 30
IS 6
BP 431
EP 437
DI 10.1016/j.blre.2016.05.003
PG 7
WC Hematology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Hematology
GA ED8AF
UT WOS:000389093400003
PM 27265538
DA 2025-06-11
ER

PT J
AU Gonzalez-Rellan, MJ
   Fondevila, MF
   Dieguez, C
   Nogueiras, R
AF Gonzalez-Rellan, Maria J.
   Fondevila, Marcos F.
   Dieguez, Carlos
   Nogueiras, Ruben
TI O-GlcNAcylation: A Sweet Hub in the Regulation of Glucose
   Metabolism in Health and Disease
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Review
DE O-GlcNAcylation; glucose; diabetes; insulin resistance; glucose
   homeostasis
ID LINKED N-ACETYLGLUCOSAMINE; BROWN ADIPOSE-TISSUE; GLCNAC TRANSFERASE;
   INSULIN-RESISTANCE; BETA-CELLS; GLUCONEOGENESIS; TRANSCRIPTION;
   SECRETION; PROTEINS; GLYCOSYLATION
AB O-GlcNAcylation is a posttranslational modification ruled by the activity of a single pair of enzymes, O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA). These two enzymes carry out the dynamic cycling of O-GlcNAcylation on a wide range of cytosolic, nuclear, and mitochondrial proteins in a nutrient- and stress-responsive manner. To maintain proper glucose homeostasis, a precise mechanism to sense blood glucose levels is required, to adapt cell physiology to fluctuations in nutrient intake to maintain glycemia within a narrow range. Disruptions in glucose homeostasis generates metabolic syndrome and type 2 diabetes. In this review we will discuss and summarize emerging findings that points O-GlcNAcylation as a hub in the control of systemic glucose homeostasis, and its involvement in the generation of insulin resistance and type 2 diabetes.
RI Nogueiras, Ruben/AAS-9427-2021; Gonzalez Rellan, Maria
   Jesus/GQR-0377-2022; Fondevila, Marcos/ABE-9087-2021; Dieguez,
   Carmen/AAC-1339-2020
OI Gonzalez Rellan, Maria Jesus/0000-0001-8986-9244; Fernandez Fondevila,
   Marcos/0000-0002-5099-3421
FU FEDER/Ministerio de Ciencia; Innovacion y Universidades-Agencia Estatal
   de Investigacion [BFU2017-87721, RTI2018-099413-B-I00,
   RED2018-102379-T]; Xunta de Galicia [2015-CP080, 2016-PG057]; Fundacion
   BBVA; Fundacion Atresmedia; European Foundation for the Study of
   Diabetes; European Community's H2020 Framework Programme (ERC Synergy
   Grant) [2019-WATCH- 810331]; Instituto de Salud Carlos III (ISCIII) of
   Spain - FEDER funds
FX This work has been supported by grants from FEDER/Ministerio de Ciencia,
   Innovacion y Universidades-Agencia Estatal de Investigacion (CD:
   BFU2017-87721; RN: RTI2018-099413-B-I00 and RED2018-102379-T), Xunta de
   Galicia (RN: 2015-CP080 and 2016-PG057), Fundacion BBVA (RN), Fundacion
   Atresmedia (RN), European Foundation for the Study of Diabetes (RN).
   This research also received funding from the European Community's H2020
   Framework Programme (ERC Synergy Grant-2019-WATCH- 810331, to RN). CIBER
   de Fisiopatologia de la Obesidad y Nutricion (CIBERobn) is an initiative
   of the Instituto de Salud Carlos III (ISCIII) of Spain which is
   supported by FEDER funds.
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NR 68
TC 21
Z9 21
U1 3
U2 11
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD APR 22
PY 2022
VL 13
AR 873513
DI 10.3389/fendo.2022.873513
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 2B9CZ
UT WOS:000810479700001
PM 35527999
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Lin, PW
   Chu, ML
   Liu, HS
AF Lin, Pei-Wen
   Chu, Man-Ling
   Liu, Hsiao-Sheng
TI Autophagy and metabolism
SO KAOHSIUNG JOURNAL OF MEDICAL SCIENCES
LA English
DT Review
DE autophagy; metabolic syndrome; secretory autophagy
ID CANCER-ASSOCIATED FIBROBLASTS; PROTEIN-DEGRADATION; PATHWAY; STRESS;
   SECRETION; MECHANISM; OBESITY; INHIBITION; REVEALS; CELLS
AB Metabolism consists of diverse life-sustaining chemical reactions in living organisms. Autophagy is a highly conservative process that responds to various internal and external stresses. Both processes utilize surrounding resources to provide energy and nutrients for the cell. Autophagy progression may proceed to the degradative or secretory pathway determined by Rab family proteins. The former is a degradative and lysosome-dependent catabolic process that produces energy and provides nutrients for the synthesis of essential proteins. The degradative pathway also balances the energy source of the cell and regulates tissue homeostasis. The latter is a newly discovered pathway in which the autophagosome is fused with the plasma membrane. Secretory autophagy participates in diverse functions and diseases ranging from the spread of viral particles to cancer and neurodegenerative diseases. Aberrant metabolism in the body causes various metabolic syndromes. This review explores the relationships among autophagy, metabolism, and related diseases.
C1 [Lin, Pei-Wen; Chu, Man-Ling; Liu, Hsiao-Sheng] Kaohsiung Med Univ, Ctr Canc Res, Coll Med, Kaohsiung, Taiwan.
   [Liu, Hsiao-Sheng] Natl Cheng Kung Univ, Coll Med, Dept Microbiol & Immunol, Tainan, Taiwan.
C3 Kaohsiung Medical University; National Cheng Kung University
RP Liu, HS (corresponding author), Kaohsiung Med Univ, Coll Med, Ctr Canc Res, Grad Inst Med, 100 Shih Chuan 1st Rd, Kaohsiung, Taiwan.
EM hsliu713@kmu.edu.tw
OI Lin, Pei-Wen/0000-0002-9744-9546; Liu, Hsiao-Sheng/0000-0003-0576-7203
FU Kaohsiung Medical University [KMU-TC108A04-0 KMU-TC]
FX Kaohsiung Medical University, Grant/Award Number: Research Center Grant
   KMU-TC108A04-0 KMU-TC
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NR 80
TC 39
Z9 44
U1 0
U2 16
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1607-551X
EI 2410-8650
J9 KAOHSIUNG J MED SCI
JI Kaohsiung J. Med. Sci.
PD JAN
PY 2021
VL 37
IS 1
BP 12
EP 19
DI 10.1002/kjm2.12299
EA OCT 2020
PG 8
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA PQ2RE
UT WOS:000576300000001
PM 33021078
OA gold
DA 2025-06-11
ER

PT J
AU Shore, SA
AF Shore, Stephanie A.
TI The Metabolic Response to Ozone
SO FRONTIERS IN IMMUNOLOGY
LA English
DT Review
DE obesity; metabolome; microbiome; fatty acids; hyperglycemia
ID AMBIENT AIR-POLLUTION; SEDENTARY LIFE-STYLE; DIET-INDUCED OBESITY;
   INDUCED LUNG INJURY; HIGH-FAT DIET; INSULIN-RESISTANCE; GUT MICROBIOTA;
   INHALED OZONE; AUGMENTED RESPONSES; INDUCED PULMONARY
AB The respiratory effects of O-3 are well established. High ambient O-3 concentrations are associated with respiratory symptoms, declines in pulmonary function, asthma exacerbations, and even mortality. The metabolic effects of O-3 are less well appreciated. Here we review data indicating that O-3 exposure leads to glucose intolerance and hyperlipidemia, characteristics of the metabolic syndrome. We also review the role of stress hormones in these events. We describe how the metabolic effects of O-3, including effects within the lungs, are exacerbated in the setting of the metabolic derangements of obesity and we discuss epidemiological data indicating an association between ambient O-3 exposure and diabetes. We conclude by describing the role of the gut microbiome in the regulation of metabolism and by discussing data indicating a link between the gut microbiome and pulmonary responses to O-3.
C1 [Shore, Stephanie A.] Harvard TH Chan Sch Publ Hlth, Dept Environm Hlth, Boston, MA 02115 USA.
C3 Harvard University; Harvard T.H. Chan School of Public Health
RP Shore, SA (corresponding author), Harvard TH Chan Sch Publ Hlth, Dept Environm Hlth, Boston, MA 02115 USA.
EM sshore@hsph.harvard.edu
FU National Institutes of Health [ES013307, ES000002]
FX This work was supported by National Institutes of Health grants ES013307
   and ES000002.
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NR 73
TC 23
Z9 25
U1 5
U2 20
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-3224
J9 FRONT IMMUNOL
JI Front. Immunol.
PD DEC 6
PY 2019
VL 10
AR 2890
DI 10.3389/fimmu.2019.02890
PG 7
WC Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology
GA JX5XP
UT WOS:000503807800001
PM 31867021
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Lea, A
   Subramaniam, M
   Ko, A
   Lehtimäki, T
   Raitoharju, E
   Kähönen, M
   Seppälä, I
   Mononen, N
   Raitakari, OT
   Ala-Korpela, M
   Pajukanta, P
   Zaitlen, N
   Ayroles, JF
AF Lea, Amanda
   Subramaniam, Meena
   Ko, Arthur
   Lehtimaki, Terho
   Raitoharju, Emma
   Kahonen, Mika
   Seppala, Ilkka
   Mononen, Nina
   Raitakari, Olli T.
   Ala-Korpela, Mika
   Pajukanta, Paivi
   Zaitlen, Noah
   Ayroles, Julien F.
TI Genetic and environmental perturbations lead to regulatory decoherence
SO ELIFE
LA English
DT Article
ID COEXPRESSION NETWORKS; COMPLEX TRAITS; CARDIOVASCULAR RISK; OXIDATIVE
   STRESS; EXPRESSION; DATABASE; CANALIZATION; DIVERSITY; DISEASE; HEART
AB Correlation among traits is a fundamental feature of biological systems that remains difficult to study. To address this problem, we developed a flexible approach that allows us to identify factors associated with inter-individual variation in correlation. We use data from three human cohorts to study the effects of genetic and environmental variation on correlations among mRNA transcripts and among N MR metabolites. We first show that environmental exposures (infection and disease) lead to a systematic loss of correlation, which we define as 'decoherence'. Using longitudinal data, we show that decoherent metabolites are better predictors of whether someone will develop metabolic syndrome than metabolites commonly used as biomarkers of this disease. Finally, we demonstrate that correlation itself is under genetic control by mapping hundreds of 'correlation quantitative trait loci (QTLs)'. Together, this work furthers our understanding of how and why coordinated biological processes break down, and points to a potential role for decoherence in disease.
C1 [Lea, Amanda; Ayroles, Julien F.] Princeton Univ, Dept Ecol & Evolut, Princeton, NJ 08544 USA.
   [Lea, Amanda; Ayroles, Julien F.] Princeton Univ, Lewis Sigler Inst Integrat Genom, Princeton, NJ 08544 USA.
   [Subramaniam, Meena; Zaitlen, Noah] Univ Calif San Francisco, Dept Med, Lung Biol Ctr, San Francisco, CA USA.
   [Ko, Arthur] Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USA.
   [Lehtimaki, Terho] Tampere Univ, Fac Med & Hlth Technol, Fimlab Labs, Dept Clin Chem, Tampere, Finland.
   [Lehtimaki, Terho; Raitoharju, Emma; Kahonen, Mika; Seppala, Ilkka; Mononen, Nina] Tampere Univ, Fac Med & Hlth Technol, Finnish Cardiovasc Res Ctr, Tampere, Finland.
   [Kahonen, Mika] Tampere Univ, Tampere Univ Hosp, Dept Clin Physiol, Tampere, Finland.
   [Raitakari, Olli T.] Univ Turku, Res Ctr Appl & Prevent Cardiovasc Med, Turku, Finland.
   [Raitakari, Olli T.] Turku Univ Hosp, Dept Clin Physiol & Nucl Med, Turku, Finland.
   [Ala-Korpela, Mika] Syst Epidemiol Baker Heart & Diabet Inst, Melbourne, Vic, Australia.
   [Ala-Korpela, Mika] Univ Oulu, Bioctr Oulu, Fac Med, Computat Med, Oulu, Finland.
   [Ala-Korpela, Mika] Univ Eastern Finland, Sch Pharm, NMR Metabol Lab, Kuopio, Finland.
   [Ala-Korpela, Mika] Univ Bristol, Bristol Med Sch, Populat Hlth Sci, Bristol, Avon, England.
   [Ala-Korpela, Mika] Univ Bristol, MRC, Integrat Epidemiol Unit, Bristol, Avon, England.
   [Ala-Korpela, Mika] Monash Univ, Fac Med Nursing & Hlth Sci, Sch Publ Hlth & Prevent Med, Alfred Hosp,Dept Epidemiol & Prevent Med, Melbourne, Vic, Australia.
   [Pajukanta, Paivi] Univ Calif Los Angeles, David Geffen Sch Med, Dept Human Genet, Los Angeles, CA 90095 USA.
C3 Princeton University; Princeton University; University of California
   System; University of California San Francisco; University of California
   System; University of California Los Angeles; University of California
   Los Angeles Medical Center; David Geffen School of Medicine at UCLA;
   Tampere University; Tampere University; Tampere University; Tampere
   University Hospital; University of Turku; University of Turku;
   University of Oulu; University of Eastern Finland; University of
   Bristol; University of Bristol; Florey Institute of Neuroscience &
   Mental Health; Howard Florey Institute Affiliates; Monash University;
   University of California System; University of California Los Angeles;
   University of California Los Angeles Medical Center; David Geffen School
   of Medicine at UCLA
RP Ayroles, JF (corresponding author), Princeton Univ, Dept Ecol & Evolut, Princeton, NJ 08544 USA.; Ayroles, JF (corresponding author), Princeton Univ, Lewis Sigler Inst Integrat Genom, Princeton, NJ 08544 USA.
EM jayroles@princeton.edu
RI Lehtimäki, Terho/AAD-1094-2022; Raitakari, Olli/AAQ-7389-2021
OI Ko, Arthur/0000-0002-1523-7225; Lea, Amanda/0000-0002-8827-2750;
   Ala-Korpela, Mika/0000-0001-5905-1206; Lehtimaki,
   Terho/0000-0002-2555-4427; Raitoharju, Emma/0000-0002-7023-8706;
   Kahonen, Mika/0000-0002-4510-7341
FU Helen Hay Whitney Foundation; National Institute of General Medical
   Sciences [F31HL127921, GM124881]; European Research Council [742927];
   Suomen Akatemia [286284, 134309, 126925, 121584, 129378, 124282, 117787,
   41071]; Horizon 2020 Framework Programme [755320]; Social Insurance
   Institution of Finland; Competitive State Research Financing of the
   Expert Re-sponsibility area of Kuopio University Hospital [X51001];
   Competitive State Research Financing of the Expert Re-sponsibility area
   of Tampere University Hospital [X51001]; Competitive State Research
   Financing of the Expert Re-sponsibility area of Turku University
   Hospital [X51001]; Juho Vainio Foundation; Paavo Nurmi Foundation;
   Finnish Foundation for Cardiovascular Research; Sigrid Juselius
   Foundation; Tampere Tuberculosis Foundation; Emil Aaltonen Foundation;
   Yrjo Jahnsson Foundation; Signe and Ane Gyllenberg Foundation; Tampere
   University Hospital; National Health and Medical Research Council
   [APP1158958]; Diabetesliitto
FX Helen Hay Whitney Foundation Postdoctoral Fellowship Amanda Lea National
   Institute of General Medical Sciences F31HL127921 Arthur Ko European
   Research Council 742927 Terho Lehtimaki Emma Raitoharju Mika Kahonen
   Ilkka Seppala Nina Mononen Olli T Raitakari Suomen Akatemia 286284 Terho
   Lehtimaki Emma Raitoharju Mika Kahonen Ilkka Seppala Nina Mononen Olli T
   Raitakari Horizon 2020 Framework Programme 755320 Terho Lehtimaki Emma
   Raitoharju Mika Kahonen Ilkka Seppala Nina Mononen Olli T Raitakari
   Suomen Akatemia 134309 (Eye) Terho Lehtimaki Emma Raitoharju Mika
   Kahonen Ilkka Seppala Nina Mononen Olli T Raitakari Suomen Akatemia
   126925 Terho Lehtimaki Emma Raitoharju Mika Kahonen Ilkka Seppala Nina
   Mononen Olli T Raitakari Suomen Akatemia 121584 Terho Lehtimaki Emma
   Raitoharju Mika Kahonen Ilkka Seppala Nina Mononen Olli T Raitakari
   Suomen Akatemia 124282 Terho Lehtimaki Emma Raitoharju Mika Kahonen
   Ilkka Seppala Nina Mononen Olli T Raitakari Suomen Akatemia 129378
   (Salve) Terho Lehtimaki Emma Raitoharju Mika Kahonen Ilkka Seppala Nina
   Mononen Olli T Raitakari Suomen Akatemia 117787 (Gendi) Terho Lehtimaki
   Emma Raitoharju Mika Kahonen Ilkka Seppala Nina Mononen Olli T Raitakari
   Suomen Akatemia 41071 (Skidi) Terho Lehtimaki Emma Raitoharju Mika
   Kahonen Ilkka Seppala Nina Mononen Olli T Raitakari The Social Insurance
   Institution of Finland Terho Lehtimaki Emma Raitoharju Mika Kahonen
   Ilkka Seppala Nina Mononen Olli T Raitakari Competitive State Research
   Financing of the Expert Re-sponsibility area of Kuopio, Tampere and
   Turku University Hospitals X51001 Terho Lehtimaki Emma Raitoharju Mika
   Kahonen Ilkka Seppala Nina Mononen Olli T Raitakari Juho Vainio
   Foundation Terho Lehtimaki Emma Raitoharju Mika Kahonen Ilkka Seppala
   Nina Mononen Olli T Raitakari Paavo Nurmi Foundation Terho Lehtimaki
   Emma Raitoharju Mika Kahonen Ilkka Seppala Nina Mononen Olli T Raitakari
   Finnish Foundation for Cardiovascular Research Terho Lehtimaki Emma
   Raitoharju Mika Kahonen Ilkka Seppala Nina Mononen Olli T Raitakari
   Finnish Cultural Foundation Terho Lehtimaki Emma Raitoharju Mika Kahonen
   Ilkka Seppala Nina Mononen Olli T Raitakari Sigrid Juselius Foundation
   Terho Lehtimaki Emma Raitoharju Mika Kahonen Ilkka Seppala Nina Mononen
   Olli T Raitakari Mika Ala-Korpela Tampere Tuberculosis Foundation Terho
   Lehtimaki Emma Raitoharju Mika Kahonen Ilkka Seppala Nina Mononen Olli T
   Raitakari Emil Aaltonen Foundation Terho Lehtimaki Emma Raitoharju Mika
   Kahonen Ilkka Seppala Nina Mononen Olli T Raitakari Yrjo Jahnsson
   Foundation Terho Lehtimaki Emma Raitoharju Mika Kahonen Ilkka Seppala
   Nina Mononen Olli T Raitakari Signe and Ane Gyllenberg Foundation Terho
   Lehtimaki Emma Raitoharju Mika Kahonen Ilkka Seppala Nina Mononen Olli T
   Raitakari Tampere University Hospital Terho Lehtimaki Emma Raitoharju
   Mika Kahonen Ilkka Seppala Nina Mononen Olli T Raitakari National Health
   and Medical Research Council APP1158958 Mika Ala-Korpela Diabetesliitto
   Paivi Pajukanta National Institute of General Medical Sciences GM124881
   Julien F Ayroles The funders had no role in study design, data
   collection and interpretation, or the decision to submit the work for
   publication.
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NR 77
TC 31
Z9 36
U1 0
U2 4
PU eLIFE SCIENCES PUBL LTD
PI CAMBRIDGE
PA SHERATON HOUSE, CASTLE PARK, CAMBRIDGE, CB3 0AX, ENGLAND
SN 2050-084X
J9 ELIFE
JI eLife
PD MAR 5
PY 2019
VL 8
AR e40538
DI 10.7554/eLife.40538
PG 28
WC Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics
GA HN7WU
UT WOS:000460404600001
PM 30834892
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Salehi, B
   Stojanovic-Radic, Z
   Matejic, J
   Sharifi-Rad, M
   Kumar, NVA
   Martins, N
   Sharifi-Rad, J
AF Salehi, Bahare
   Stojanovic-Radic, Zorica
   Matejic, Jelena
   Sharifi-Rad, Mehdi
   Kumar, Nanjangud V. Anil
   Martins, Natalia
   Sharifi-Rad, Javad
TI The therapeutic potential of curcumin: A review of clinical trials
SO EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
LA English
DT Review
DE Curcuma longa L.; Secondary metabolites; Curcuminoids; Pharmacological
   effects; Clinical trials
ID RANDOMIZED CONTROLLED-TRIAL; MAJOR DEPRESSIVE DISORDER; DOUBLE-BLIND;
   METABOLIC SYNDROME; ORAL CURCUMIN; KNEE OSTEOARTHRITIS; OXIDATIVE
   STRESS; PHASE-I; BIOAVAILABLE CURCUMIN; PIPERINE COMBINATION
AB Curcuma longa L., its derived extracts and even its major compound curcumin has a long history of use and doubtless effectiveness, reported through increasingly detailed in vitro, ex vivo, in vivo and even clinical trials. Regarding its biological effects, multiple health-promoting, disease-preventing and even treatment attributes has been remarkably highlighted. Clinical trials, although have increased in a progressive manner, significant disproportionalities have been stated in terms of biological effects assessment. In this sense, the present report aims to provide an extensive overview to curcumin therapeutic effects in human subjects. For that, clinical trials assessing the curcumin effect on inflammation, skin, eye, central nervous system, respiratory, cardiovascular, gastrointestinal, urogenital and metabolic disorders are here presented and discussed. A special emphasis was also given to curcumin activity on intoxications and multiple malignant diseases. (C) 2018 Elsevier Masson SAS. All rights reserved.
C1 [Salehi, Bahare] Bam Univ Med Sci, Bam, Iran.
   [Stojanovic-Radic, Zorica] Univ Nis, Fac Sci & Math, Dept Biol & Ecol, Visegradska 33, Nish 18000, Serbia.
   [Matejic, Jelena] Univ Nis, Fac Med, Dept Pharm, Blvd Dr Zorana Dinatica 81, Nish 18000, Serbia.
   [Sharifi-Rad, Mehdi] Zabol Univ Med Sci, Dept Med Parasitol, Zabol 61663335, Iran.
   [Kumar, Nanjangud V. Anil] Manipal Acad Higher Educ, Manipal Inst Technol, Dept Chem, Manipal 576104, Karnataka, India.
   [Martins, Natalia] Univ Porto, Fac Med, Alameda Prof Hernani Monteiro, P-4200319 Porto, Portugal.
   [Martins, Natalia] Univ Porto, Inst Res & Innovat Hlth i3S, P-4200135 Porto, Portugal.
   [Sharifi-Rad, Javad] Zabol Univ Med Sci, Zabol Med Plants Res Ctr, Zabol, Iran.
   [Sharifi-Rad, Javad] Univ Winnipeg, Dept Chem, Richardson Coll Environm Sci Complex, Winnipeg, MB R3B 2G3, Canada.
C3 University of Nis; University of Nis; Manipal Academy of Higher
   Education (MAHE); Universidade do Porto; Universidade do Porto; i3S -
   Instituto de Investigacao e Inovacao em Saude, Universidade do Porto;
   University of Winnipeg
RP Stojanovic-Radic, Z (corresponding author), Univ Nis, Fac Sci & Math, Dept Biol & Ecol, Visegradska 33, Nish 18000, Serbia.; Sharifi-Rad, M (corresponding author), Zabol Univ Med Sci, Dept Med Parasitol, Zabol 61663335, Iran.; Martins, N (corresponding author), Univ Porto, Fac Med, Alameda Prof Hernani Monteiro, P-4200319 Porto, Portugal.; Sharifi-Rad, J (corresponding author), Shahid Beheshti Univ Med Sci, Phytochem Res Ctr, Tehran 11369, Iran.
EM bahar.salehi007@gmail.com; zstojanovicradic@yahoo.com;
   jekamatejic@gmail.com; mehdi_sharifirad@yahoo.com; nv.anil@manipal.edu;
   ncmartins@med.up.pt; javad.sharifirad@gmail.com
RI Kumar, NV/G-6962-2015; Sharifi-Rad, Javad/D-5747-2016; Cruz-Martins,
   Natalia/P-2972-2015
OI Sharifi-Rad, Javad/0000-0002-7301-8151; Cruz-Martins,
   Natalia/0000-0002-5934-5201; Anil Kumar, NV/0000-0002-8016-8991;
   Matejic, Jelena/0000-0001-6410-4296; Stojanovic-Radic,
   Zorica/0000-0003-1694-3823
FU Vice-chancellor for Research Affairs of Shahid Beheshti University of
   Medical Sciences, Tehran, Iran; Vicerrectoria de Investigacion y
   Desarrollo from University of Concepcion, Chile [216.073.031-1.0IN,
   217.073.033-1.0]; Portuguese Foundation for Science and Technology
   (FCT-Portugal) [UID/BIM/04293/2013]; NORTE2020-Programa Operacional
   Regional do Norte [NORTE-01-0145-FEDER-000012]
FX This work was supported by the Vice-chancellor for Research Affairs of
   Shahid Beheshti University of Medical Sciences, Tehran, Iran and
   Vicerrectoria de Investigacion y Desarrollo from University of
   Concepcion, Chile (216.073.031-1.0IN and 217.073.033-1.0). N.M. thank to
   Portuguese Foundation for Science and Technology (FCT-Portugal) for the
   Strategic project ref. UID/BIM/04293/2013 and "NORTE2020-Programa
   Operacional Regional do Norte" (NORTE-01-0145-FEDER-000012).
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NR 152
TC 369
Z9 384
U1 5
U2 138
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0223-5234
EI 1768-3254
J9 EUR J MED CHEM
JI Eur. J. Med. Chem.
PD FEB 1
PY 2019
VL 163
BP 527
EP 545
DI 10.1016/j.ejmech.2018.12.016
PG 19
WC Chemistry, Medicinal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA HL3FC
UT WOS:000458597300040
PM 30553144
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Zhang, X
   Ji, XT
   Wang, Q
   Li, JZ
AF Zhang, Xu
   Ji, Xuetao
   Wang, Qian
   Li, John Zhong
TI New insight into inter-organ crosstalk contributing to the pathogenesis
   of non-alcoholic fatty liver disease (NAFLD)
SO PROTEIN & CELL
LA English
DT Review
DE non-alcoholic fatty liver disease; hepatic lipid metabolism;
   hypothalamus; gut-liver axis; adipose tissue
ID INDUCED INSULIN-RESISTANCE; FARNESOID-X-RECEPTOR; HYPOTHALAMIC ARCUATE
   NUCLEUS; ENDOPLASMIC-RETICULUM STRESS; HEPATIC VLDL SECRETION;
   DIET-INDUCED OBESITY; DE-NOVO LIPOGENESIS; GUT MICROBIOTA;
   ADIPOSE-TISSUE; LIPID DROPLETS
AB Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver dysfunction and a significant global health problem with substantial rise in prevalence over the last decades. It is becoming increasingly clear that NALFD is not only predominantly a hepatic manifestation of metabolic syndrome, but also involves extra-hepatic organs and regulatory pathways. Therapeutic options are limited for the treatment of NAFLD. Accordingly, a better understanding of the pathogenesis of NAFLD is critical for gaining new insight into the regulatory network of NAFLD and for identifying new targets for the prevention and treatment of NAFLD. In this review, we emphasize on the current understanding of the inter-organ crosstalk between the liver and peripheral organs that contributing to the pathogenesis of NAFLD.
C1 [Zhang, Xu; Ji, Xuetao; Wang, Qian; Li, John Zhong] Nanjing Med Univ, Sch Basic Med Sci, Dept Biochem & Mol Biol, Nanjing 211166, Jiangsu, Peoples R China.
   [Zhang, Xu; Ji, Xuetao; Wang, Qian; Li, John Zhong] Nanjing Med Univ, Jiangsu Prov Key Lab Human Funct Genom, Nanjing 211166, Jiangsu, Peoples R China.
C3 Nanjing Medical University; Nanjing Medical University
RP Wang, Q; Li, JZ (corresponding author), Nanjing Med Univ, Sch Basic Med Sci, Dept Biochem & Mol Biol, Nanjing 211166, Jiangsu, Peoples R China.; Wang, Q; Li, JZ (corresponding author), Nanjing Med Univ, Jiangsu Prov Key Lab Human Funct Genom, Nanjing 211166, Jiangsu, Peoples R China.
EM wqian@njmu.edu.cn; lizhong@njmu.edu.cn
RI Li, John Zhong/U-2157-2017
OI Li, John Zhong/0000-0003-4991-9563
FU National Natural Science Foundation of China [81471079, 31271268,
   81271828]; National Basic Research Program (973 Program) [2012CB517503,
   2013CB530600]; Nanjing Medical University [2016NJMU004]
FX The authors thank Dr. Yongjian Liu (Nanjing Medical University) for his
   critical reading and useful suggestions. This work was supported by the
   National Natural Science Foundation of China (Grant Nos. 81471079,
   31271268, and 81271828); the National Basic Research Program (973
   Program) (No. 2012CB517503 and 2013CB530600); and a
   Technology/Development Fund of Nanjing Medical University (2016NJMU004).
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NR 183
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Z9 101
U1 2
U2 37
PU SPRINGEROPEN
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 1674-800X
EI 1674-8018
J9 PROTEIN CELL
JI Protein Cell
PD FEB
PY 2018
VL 9
IS 2
BP 164
EP 177
DI 10.1007/s13238-017-0436-0
PG 14
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WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
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OA Green Published, gold
DA 2025-06-11
ER

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SO WORK AND STRESS
LA English
DT Article
DE Workaholism; sleep problems; cardiovascular risk; work-related stress
ID CORONARY-HEART-DISEASE; METABOLIC SYNDROME; ENGAGEMENT; HYPERTENSION;
   ASSOCIATION; PERSONALITY; INCREASES; BEHAVIOR; QUALITY; EVENTS
AB This study tests the relationships between workaholism (i.e. working excessively and compulsively), sleep problems and cardiovascular risk in 537 employees from five Spanish hospitals. Four types of worker (i.e. workaholics, positive workers, compulsive workers and hard workers) were distinguished, and their health indicators were compared. The results showed that workaholics experienced significantly more sleep problems (i.e. morning tiredness, sleeping while driving and sleeping fewer hours both on weekdays and at weekends, with poorer quality), had higher relative risk scores, and consumed more caffeine and alcohol than the other patterns of worker (positive, compulsive and hard workers). Further analyses revealed that sleep problems fully mediated the relationship between workaholism (i.e. working excessively and compulsively) and cardiovascular risk. The study emphasizes the fact that being a workaholic might be a significant risk factor for having sleep problems and cardiovascular disease.
C1 [Salanova, Marisa; Llorens, Susana] Univ Jaume 1, Dept Social Psychol, WANT Res Unit, Castellon de La Plana, Spain.
   [Arturo Lopez-Gonzalez, Angel; Teofila Vicente-Herrero, Ma; Tomas-Salva, Matias] Univ Ies Illes Balears, IUNICS Inst Univ Invest Ciencies Salut, Occupat Hlth Res Unit, Palma De Mallorca, Spain.
   [del Libano, Mario] Univ Burgos, Educ Sci Dept, Burgos, Spain.
C3 Universitat Jaume I; Universidad de Burgos
RP Salanova, M (corresponding author), Univ Jaume 1, Dept Social Psychol, WANT Res Unit, Castellon de La Plana, Spain.
EM salanova@uji.es
RI López, Ángel/AAN-2248-2021; Salanova, Marisa/B-4354-2011; Del Libano,
   Mario/O-6482-2015; Llorens Gumbau, Susana/C-9719-2011
OI Tomas-Salva, Matias/0000-0002-5252-6974; Del Libano,
   Mario/0000-0001-6190-2778; Llorens Gumbau, Susana/0000-0001-7545-5286
FU PROMETEO Generalitat Valenciana [PROMETEO/2013/ 025]; Universitat Jaume
   I [P1.1B2014-40]; Research Group on Occupational Health (IUNICS)
FX This study was supported by grants from PROMETEO Generalitat Valenciana
   [PROMETEO/2013/ 025], Universitat Jaume I [P1.1B2014-40] and the
   Research Group on Occupational Health (IUNICS).
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NR 53
TC 61
Z9 73
U1 2
U2 46
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0267-8373
EI 1464-5335
J9 WORK STRESS
JI Work Stress
PD JUL-SEP
PY 2016
VL 30
IS 3
BP 228
EP 242
DI 10.1080/02678373.2016.1203373
PG 15
WC Psychology, Applied
WE Social Science Citation Index (SSCI)
SC Psychology
GA DV2QV
UT WOS:000382766700002
OA Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Habtemariam, S
   Varghese, GK
AF Habtemariam, Solomon
   Varghese, George K.
TI The Antidiabetic Therapeutic Potential of Dietary Polyphenols
SO CURRENT PHARMACEUTICAL BIOTECHNOLOGY
LA English
DT Article
DE Anti-inflammatory; antioxidant; diabetes; enzyme inhibition; fatty acids
   metabolism; glucose metabolism; polyphenols; receptor modulation
ID ACTIVATED PROTEIN-KINASE; PANCREATIC BETA-CELLS; NECROSIS-FACTOR-ALPHA;
   GREEN TEA CATECHINS; INSULIN-RESISTANCE; OXIDATIVE STRESS; PPAR-GAMMA;
   DIABETES-MELLITUS; ADIPOSE-TISSUE; GLUCOSE-UPTAKE
AB Type-2 diabetes (T2D) is a complex metabolic syndrome that is characterized by persistent hyperglycemia due to either lack of insulin secretion and/or insulin resistance. The prevalence of T2D along with its major risk factor, obesity, has been increasing with an epidemic proportion in recent years. To date, there is no drug of cure for diabetes and the existing therapeutic approaches have serious drawbacks including side effects and loss of efficacy during prolonged use. Dietary polyphenols are one group of natural products that have shown promise as potential antidiabetic agents. In this review, their molecular mechanisms of action including, antioxidant, anti-inflammatory, receptor agonist/antagonist effect and modulation of key signal transduction cascades, glucose transport, enzyme activity, receptor agonistic/antagonist effect, etc. in major insulin-sensitive cells are discussed.
C1 [Habtemariam, Solomon] Univ Greenwich, Medway Sch Sci, Pharmacognosy Res Labs, Chatham ME4 4TB, Kent, England.
   [Varghese, George K.] CMS Coll, Dept Bot, Kottayam, Kerala, India.
C3 University of Greenwich
RP Habtemariam, S (corresponding author), Univ Greenwich, Medway Sch Sci, Pharmacognosy Res Labs, Chatham ME4 4TB, Kent, England.
EM s.habtemariam@gre.ac.uk
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NR 152
TC 72
Z9 72
U1 2
U2 27
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1389-2010
EI 1873-4316
J9 CURR PHARM BIOTECHNO
JI Curr. Pharm. Biotechnol.
PY 2014
VL 15
IS 4
BP 391
EP 400
DI 10.2174/1389201015666140617104643
PG 10
WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
GA AN6OV
UT WOS:000340715400011
PM 24938887
DA 2025-06-11
ER

PT J
AU Zhang, XY
   Song, XY
   Hu, XS
   Chen, F
   Ma, C
AF Zhang, Xiaoying
   Song, Xunyu
   Hu, Xiaosong
   Chen, Fang
   Ma, Chen
TI Health benefits of proanthocyanidins linking with gastrointestinal
   modulation: An updated review
SO FOOD CHEMISTRY
LA English
DT Review
DE Proanthocyanidins; Intestinal function; Gut microbiomes; Bioactivity;
   Mechanisms
ID GRAPE-SEED PROANTHOCYANIDINS; GUT MICROBIOTA; INTESTINAL BARRIER; RED
   WINE; (-)-EPICATECHIN; INFLAMMATION; MECHANISMS; EXTRACTS; DISEASE;
   STRESS
AB Proanthocyanidins (PACs) are the bioactive components naturally present in daily diet, especially in fruits and vegetables. Multiple pieces of evidence suggested that ingestion of PACs or diets full of PACs might contribute to physiological benefits, such as metabolic syndrome regulation, immune modulation, cancer prevention, and neuroprotection. Many studies stated that dysbiosis is closely linked with the abovementioned health conditions, and the extremely poor bioavailability of PACs, directly associated with the structural diversity, leads to extensively metabolized through gut microbiota (GM). GM transforms PACs into bioactive metabolites. Conversely, PACs also modulate the gut microbiome and the composition of GM. Thus, the complex bidirectional interactions between PACs and gut microbiota might help to understand the ambiguity between bioavailability and pleiotropic bioactivity. In this review, we summarize recent in vivo and in vitro studies from the aspect of intestinal function of PACs and its associated disease, as well as the underlying mechanisms.
C1 [Zhang, Xiaoying; Song, Xunyu; Hu, Xiaosong; Chen, Fang; Ma, Chen] China Agr Univ, Coll Food Sci & Nutr Engn, Natl Engn Res Ctr Fruit & Vegetable Proc, Engn Res Ctr Fruits & Vegetables Proc,Minsit Educ, Beijing 100083, Peoples R China.
C3 China Agricultural University
RP Ma, C (corresponding author), China Agr Univ, Coll Food Sci & Nutr Engn, Natl Engn Res Ctr Fruit & Vegetable Proc, Engn Res Ctr Fruits & Vegetables Proc,Minsit Educ, Beijing 100083, Peoples R China.
EM machen21@sina.com
RI 张, 晓颖/ABD-9142-2021; Hu, Xiaosong/Y-2494-2019; chen, fang/KVA-6644-2024
OI song, Xunyu/0009-0004-0592-4613
FU National Key Research and Develop-ment Program of China; 
   [2017YFD0400705]
FX 4. Funding source This work was supported by National Key Research and
   Develop-ment Program of China (2017YFD0400705) .
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NR 70
TC 21
Z9 21
U1 11
U2 75
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 0308-8146
EI 1873-7072
J9 FOOD CHEM
JI Food Chem.
PD MAR 15
PY 2023
VL 404
AR 134596
DI 10.1016/j.foodchem.2022.134596
EA NOV 2022
PN A
PG 9
WC Chemistry, Applied; Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Food Science & Technology; Nutrition & Dietetics
GA 6H9OU
UT WOS:000885760600001
PM 36444018
DA 2025-06-11
ER

PT J
AU Koushki, M
   Amiri-Dashatan, N
   Ahmadi, N
   Abbaszadeh, HA
   Rezaei-Tavirani, M
AF Koushki, Mehdi
   Amiri-Dashatan, Nasrin
   Ahmadi, Nayebali
   Abbaszadeh, Hojjat-Allah
   Rezaei-Tavirani, Mostafa
TI Resveratrol: A miraculous natural compound for diseases treatment
SO FOOD SCIENCE & NUTRITION
LA English
DT Review
DE antioxidant; dietary; natural compound; polyphenol; resveratrol
ID MEDIATED OXIDATIVE STRESS; LOW-DENSITY-LIPOPROTEIN; PANCREATIC
   BETA-CELL; FACTOR-KAPPA-B; RED WINE; TRANS-RESVERATROL; IN-VITRO;
   NITRIC-OXIDE; INDUCED INFLAMMATION; CARCINOMA CELLS
AB Resveratrol (3, 5, 4 '-trihydroxystilbene) is a nonflavonoid polyphenol that naturally occurs as phytoalexin. It is produced by plant sources such as grapes, apples, blueberries, plums, and peanut. This compound has critical roles in human health and is well known for its diverse biological activities such as antioxidant and anti-inflammatory properties. Nowadays, due to rising incidence of different diseases such as cancer and diabetes, efforts to find novel and effective disease-protective agents have led to the identification of plant-derived compounds such as resveratrol. Furthermore, several in vitro and in vivo studies have revealed the effectiveness of resveratrol in various diseases such as diabetes mellitus, cardiovascular disease, metabolic syndrome, obesity, inflammatory, neurodegenerative, and age-related diseases. This review presents an overview of currently available studies on preventive properties and essential molecular mechanisms involved in various diseases.
C1 [Koushki, Mehdi] Univ Tehran Med Sci, Dept Biochem, Fac Med, Tehran, Iran.
   [Amiri-Dashatan, Nasrin] Shahid Beheshti Univ Med Sci, Prote Res Ctr, Student Res Comm, Tehran, Iran.
   [Ahmadi, Nayebali; Rezaei-Tavirani, Mostafa] Shahid Beheshti Univ Med Sci, Fac Paramed Sci, Prote Res Ctr, Tehran, Iran.
   [Abbaszadeh, Hojjat-Allah] Shahid Beheshti Univ Med Sci, Hearing Disorders Res Ctr, Tehran, Iran.
C3 Tehran University of Medical Sciences; Shahid Beheshti University
   Medical Sciences; Shahid Beheshti University Medical Sciences; Shahid
   Beheshti University Medical Sciences
RP Rezaei-Tavirani, M (corresponding author), Shahid Beheshti Univ Med Sci, Paramed Fac, Tehran, Iran.
EM tavirany@yahoo.com
RI Rezaei-Tavirani, Mostafa/I-2407-2017; Abbaszadeh, Hojjat/R-6726-2019;
   Amiri-Dashatan, Nasrin/AEZ-7029-2022; Koushki, Mehdi/ABF-6819-2020
OI Abbaszadeh, Hojjat Allah/0000-0002-7157-1834; Rezaei-Tavirani,
   Mostafa/0000-0003-1767-7475
FU Proteomics Research Center, Shahid Beheshti University of Medical
   Science
FX Proteomics Research Center, Shahid Beheshti University of Medical
   Science
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NR 178
TC 193
Z9 200
U1 6
U2 28
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2048-7177
J9 FOOD SCI NUTR
JI Food Sci. Nutr.
PD NOV
PY 2018
VL 6
IS 8
BP 2473
EP 2490
DI 10.1002/fsn3.855
PG 18
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA HC0BJ
UT WOS:000451459700053
PM 30510749
OA hybrid, Green Published
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Villela, NR
   Kramer-Aguiar, LG
   Bottino, DA
   Wiernsperger, N
   Bouskela, E
AF Villela, Nivaldo Ribeiro
   Kramer-Aguiar, Luiz Gulherme
   Bottino, Daniel Alexandre
   Wiernsperger, Nicolas
   Bouskela, Eliete
TI Metabolic disturbances linked to obesity: the role of impaired tissue
   perfusion
SO ARQUIVOS BRASILEIROS DE ENDOCRINOLOGIA E METABOLOGIA
LA English
DT Review
DE Obesity; endothelial dysfunction; microcirculation; tissue perfusion;
   metabolic syndrome
ID ENDOTHELIUM-DEPENDENT VASODILATION; MUSCLE INTERSTITIAL FLUID;
   NITRIC-OXIDE; INSULIN-RESISTANCE; SKELETAL-MUSCLE; BLOOD-FLOW;
   MICROVASCULAR RAREFACTION; ADIPOSE-TISSUE; CORONARY ATHEROSCLEROSIS;
   CAPILLARY RECRUITMENT
AB Associated with elevated risk of cardiovascular events and cancer, obesity is a worldwide problem affecting developed and developing countries. Microcirculatory vessels, represented by arterioles, capillaries and venules (mean internal diameter < 100 mu m), are the place where blood/tissue nutrition and exchange effectively take place. Microvascular dysfunction is an early event in obesity probably secondary to endothelial dysfunction and capillaries rarefaction. New research techniques allow the investigation of the microcirculation in different vascular beds in humans. Studies suggest a link between endothelial dysfunction and visceral obesity. Oxidative stress, inflammation and rennin-angiotensin system are among factors considered to be involved on microvascular dysfunction in obesity. Microcirculatory impairment present in obesity suggests that it could be an important causal factor in obesity-related disorders such as insulin resistance and hypertension. Arq Bras Endocrinol Metab. 2009;53(2):238-245,
C1 [Villela, Nivaldo Ribeiro; Kramer-Aguiar, Luiz Gulherme; Bottino, Daniel Alexandre; Bouskela, Eliete] Univ Estado Rio de Janeiro, Lab Pesquisas Clin & Expt Biol Vasc BioVasc, Ctr Biomed, BR-20550013 Rio De Janeiro, Brazil.
   [Wiernsperger, Nicolas; Bouskela, Eliete] French Natl Inst Hlth & Med Res, INSERM, UMR870, INSA Lyon, F-69008 Lyon, France.
C3 Universidade do Estado do Rio de Janeiro; Institut National des Sciences
   Appliquees de Lyon - INSA Lyon; Institut National de la Sante et de la
   Recherche Medicale (Inserm)
RP Bouskela, E (corresponding author), Univ Estado Rio de Janeiro, Lab Clin & Expt Res Vasc Biol, Terreo Rua Sao Francisco Xavier 524, BR-20550013 Rio De Janeiro, Brazil.
EM eliete_bouskela@yahoo.com.br
RI Bottino, Daniel/HGC-9753-2022
FU National Research Council (CNPq) [474116/2008-5]; Fundcao de Amparo
   Pesquisa do Estado do Rio de Janeiro (Faperj) [E-26/110.318/2007]
FX The authors wish to thank Ms. Fatima Zely Garcia de Almeida Cyrino and
   Ms. Priscila Alves Maranhao for excellent technical help. Grants: The
   study has been supported by grants from the National Research Council
   (CNPq) 474116/2008-5 and Fundcao de Amparo Pesquisa do Estado do Rio de
   Janeiro (Faperj) E-26/110.318/2007.
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NR 74
TC 19
Z9 21
U1 0
U2 4
PU SBEM-SOC BRASIL ENDOCRINOLOGIA & METABOLOGIA
PI RIO DE JANEIRO, RJ
PA RUA HUMAITA, 85 CJ 501, RIO DE JANEIRO, RJ, 22261-000, BRAZIL
SN 0004-2730
EI 1677-9487
J9 ARQ BRAS ENDOCRINOL
JI Arq. Bras. Endocrinol. Metabol.
PD MAR
PY 2009
VL 53
IS 2
BP 238
EP 245
DI 10.1590/S0004-27302009000200015
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 434QE
UT WOS:000265288400015
PM 19466216
OA Green Submitted, gold
DA 2025-06-11
ER

PT J
AU John, EE
   Valson, AT
   George, R
   Grace, PJ
   Anthony, P
   Jose, N
   Mani, SSR
   Johny, J
   Alam, R
   Lalwani, M
   Eapen, JJ
   Yusuf, S
   Thomas, A
   Alexander, S
   David, VG
   Christudoss, P
   Mammen, J
   Varughese, S
AF John, Elenjickal E.
   Valson, Anna T.
   George, Reena
   Grace, Phanny J.
   Anthony, Parimala
   Jose, Nisha
   Mani, Selvin S. R.
   Johny, Joseph
   Alam, Rizwan
   Lalwani, Manish
   Eapen, Jeethu Joseph
   Yusuf, Sabina
   Thomas, Athul
   Alexander, Suceena
   David, Vinoi George
   Christudoss, Pamela
   Mammen, Joy
   Varughese, Santosh
TI Impact of Noncommunicable Diseases and Heat Stress on Estimated
   Glomerular Filtration Rate in Security Officers at a Tertiary Care
   Hospital in South India
SO INDIAN JOURNAL OF NEPHROLOGY
LA English
DT Article
DE Chronic kidney disease; Diabetes; Glomerular filtration rate; Heat
   stress; Obesity; Security officers
ID METABOLIC SYNDROME; OBESITY; RISK; PREVALENCE; VALIDATION; HEALTH;
   QUESTIONNAIRE; EPIDEMIOLOGY; CHALLENGES; EXERCISE
AB Background: The job profile of security officers in tropical countries involves prolonged standing in hot conditions causing heat stress as well as complications of sedentary lifestyle. The objectives of this study were to estimate the prevalence of noncommunicable diseases and heat stress in security officers and analyze factors affecting heat stress and estimated glomerular filtration rate (eGFR). Materials and Methods: This was an observational cross-sectional study conducted among security personnel working at a tertiary care hospital in South India during the hottest months of March to May 2020. Screening camps were conducted during which anthropometric measurements were taken and blood was collected for hemoglobin, creatinine, and fasting glucose estimation. Urine dipstick analysis for glucose, protein, pH, and red and white blood cells were done on early morning voided sample. Heat stress was assessed by a validated 18- item questionnaire called heat strain score index (HSSI). A structured questionnaire was prepared for surveillance of risk factors of noncommunicable diseases. Results: A total of 678 security officers were screened. Majority (659/678, 97.2%) were men and mean age of the cohort was 45.4 +/- 9.2 years. Fifty-two percent (355/678) of participants were engaged in outdoor work for a median duration of 6 (IQR, 0-8) hours/day. Prevalence of obesity, diabetes, hypertension, and chronic kidney disease (CKD) were 70.9, 25.5, 15.9 and 1.3 percentage, respectively. Half of the cohort (324/678) had definite heat stress and 0.9% (6/678) developed CKD of undetermined etiology. Heat stress was higher in those working outdoors and longer employment duration and lower in those with abdominal obesity. eGFR was lower in older officers, smokers, hypertensives, and those with longer employment duration, but was unaffected by HSSI scores. Conclusion: Kidney function was unaffected by high levels of heat stress experienced by security personnel working at a tertiary hospital in South India. Future studies are needed to understand the pathomechanisms of differential impacts of heat stress on kidney function of agricultural various worker categories.
C1 [John, Elenjickal E.; Valson, Anna T.; George, Reena; Grace, Phanny J.; Anthony, Parimala; Jose, Nisha; Mani, Selvin S. R.; Johny, Joseph; Alam, Rizwan; Lalwani, Manish; Eapen, Jeethu Joseph; Yusuf, Sabina; Thomas, Athul; Alexander, Suceena; David, Vinoi George; Varughese, Santosh] Christian Med Coll & Hosp, Dept Nephrol, Vellore, Tamil Nadu, India.
   [Christudoss, Pamela] Christian Med Coll & Hosp, Dept Clin Biochem, Vellore, Tamil Nadu, India.
   [Mammen, Joy] Christian Med Coll & Hosp, Dept Transfus Med, Vellore, Tamil Nadu, India.
C3 Christian Medical College & Hospital (CMCH) Vellore; Christian Medical
   College & Hospital (CMCH) Vellore; Christian Medical College & Hospital
   (CMCH) Vellore
RP John, EE (corresponding author), Christian Med Coll & Hosp, Dept Nephrol, Vellore, Tamil Nadu, India.
EM sonyjohn84@gmail.com
RI Valson, Anna/CAF-5561-2022; Elenjickal, Elias/LDF-9361-2024; Varughese,
   Santosh/W-5989-2019
FU Christian Medical College Vellore [12003]
FX Financial support and sponsorship: The work was supported by the
   Internal major grant no: 12003 to EEJ dated 24.04.2019 from Christian
   Medical College Vellore.
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NR 43
TC 0
Z9 0
U1 0
U2 0
PU SCIENTIFIC SCHOLAR LLC
PI PITTSFORD
PA 50, WOODGREEN DR, PITTSFORD, NY 14534 USA
SN 0971-4065
EI 1998-3662
J9 INDIAN J NEPHROL
JI Indian J. Nephrol.
PD MAR-APR
PY 2025
VL 35
IS 2
BP 243
EP 252
DI 10.25259/ijn_386_23
PG 10
WC Urology & Nephrology
WE Emerging Sources Citation Index (ESCI)
SC Urology & Nephrology
GA 0DF0D
UT WOS:001444578800011
PM 40060069
OA gold
DA 2025-06-11
ER

PT J
AU Meijssen, S
   Derksen, RJ
   Bilecen, S
   Erkelens, DW
   Cabezas, MC
AF Meijssen, S
   Derksen, RJ
   Bilecen, S
   Erkelens, DW
   Cabezas, MC
TI In vivo modulation of plasma free fatty acids in patients with
   familial combined hyperlipidemia using lipid-lowering medication
SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Article
ID ACYLATION-STIMULATING PROTEIN; HORMONE-SENSITIVE LIPASE;
   CORONARY-ARTERY-DISEASE; INSULIN-RESISTANCE; ADIPOSE-TISSUE;
   HEALTHY-SUBJECTS; HEART-DISEASE; ADIPOCYTE; METABOLISM; LIPOLYSIS
AB One of the best studied aspects of the insulin resistance syndrome in familial combined hyperlipidemia (FCHL) is impaired insulin-mediated suppression of FFA by diminished inhibition of hormone-sensitive lipase (HSL). In vitro experiments have shown that stimulation of HSL activity by catecholamines is decreased in FCHL. The aim of this study was to investigate HSL inhibition by insulin and stimulation by endogenous catecholamines in vivo in FCHL patients. Twelve FCHL subjects using lipid-lowering medication and 12 controls underwent a mental stress test after random ingestion of either 50 g glucose or placebo. After ingestion of glucose, insulin concentrations increased from 76.8 +/- 21.5 pM to a maximum of 520.2 +/- 118.4 pm (P < 0.01) in FCHL and from 38.0 +/- 5.0 to 221.7 +/- 25.1 pM (P < 0.01) in controls. The percent decreases in plasma FFA during the first hour after glucose ingestion were similar in FCHL and controls (67 +/- 5% vs. 72 +/- 3%, respectively), suggesting a comparable inhibition of HSL in both. During the placebo test, FFA increased similarly in FCHL (56 +/- 9%) and controls (57 +/- 19%). In contrast, FFA concentrations did not change during mental stress after ingestion of glucose (from 0.17 +/- 0.02 to 0.15 +/- 0.02 mmobqiter in FCHL and from 0.11 +/- 0.02 to 0.12 +/- 0.02 mmol/liter in controls).
   In conclusion, the present study provides in vivo evidence for intact insulin-mediated suppression of FFA in FCHL, although this inhibition of HSL was achieved by higher insulin levels, suggesting insulin resistance at the level of HSL. Secondly, the induction of HSL activity by endogenous catecholamines in vivo is not decreased in FCHL, in contrast to earlier in vitro findings. Finally, catecholamine-induced HSL activation can be inhibited by insulin in a similar manner in both FCHL and controls.
C1 Univ Med Ctr Utrecht, Dept Vasc Med, NL-3508 GA Utrecht, Netherlands.
C3 Utrecht University; Utrecht University Medical Center
RP Univ Med Ctr Utrecht, Dept Vasc Med, F0,POB 85500, NL-3508 GA Utrecht, Netherlands.
EM m.castrocabezas@azu.nl
RI Derksen, Robert Jan/CAH-7850-2022
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NR 32
TC 8
Z9 8
U1 0
U2 0
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0021-972X
EI 1945-7197
J9 J CLIN ENDOCR METAB
JI J. Clin. Endocrinol. Metab.
PD APR
PY 2002
VL 87
IS 4
BP 1576
EP 1580
DI 10.1210/jc.87.4.1576
PG 5
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 541AM
UT WOS:000174963100024
PM 11932285
DA 2025-06-11
ER

PT J
AU Yang, WB
   Jiang, W
   Guo, SD
AF Yang, Wanbao
   Jiang, Wen
   Guo, Shaodong
TI Regulation of Macronutrients in Insulin Resistance and Glucose
   Homeostasis during Type 2 Diabetes Mellitus
SO NUTRIENTS
LA English
DT Review
DE macronutrients; insulin resistance; glucose homeostasis; type 2 diabetes
   mellitus
ID CHAIN FATTY-ACIDS; DIETARY-PROTEIN INTAKE; ENDOPLASMIC-RETICULUM STRESS;
   RANDOMIZED CONTROLLED-TRIALS; ALPHA CELL HYPERPLASIA; BRANCHED-CHAIN;
   AMINO-ACID; SKELETAL-MUSCLE; ADIPOSE-TISSUE; BODY-WEIGHT
AB Insulin resistance is an important feature of metabolic syndrome and a precursor of type 2 diabetes mellitus (T2DM). Overnutrition-induced obesity is a major risk factor for the development of insulin resistance and T2DM. The intake of macronutrients plays a key role in maintaining energy balance. The components of macronutrients distinctly regulate insulin sensitivity and glucose homeostasis. Precisely adjusting the beneficial food compound intake is important for the prevention of insulin resistance and T2DM. Here, we reviewed the effects of different components of macronutrients on insulin sensitivity and their underlying mechanisms, including fructose, dietary fiber, saturated and unsaturated fatty acids, and amino acids. Understanding the diet-gene interaction will help us to better uncover the molecular mechanisms of T2DM and promote the application of precision nutrition in practice by integrating multi-omics analysis.
C1 [Yang, Wanbao; Jiang, Wen; Guo, Shaodong] Texas A&M Univ, Coll Agr & Life Sci, Dept Nutr, College Stn, TX 77843 USA.
C3 Texas A&M University System; Texas A&M University College Station
RP Guo, SD (corresponding author), Texas A&M Univ, Coll Agr & Life Sci, Dept Nutr, College Stn, TX 77843 USA.
EM wanbao.yang@ag.tamu.edu; jiangwen@tamu.edu; shaodong.guo@ag.tamu.edu
OI Guo, Shaodong/0000-0001-5126-731X
FU National Institutes of Health [R01 DK095118, R01DK124588, R01 DK120968];
   American Diabetes Association Career Development Award [1-15-CD-09];
   Texas A&M University Health Science Center and AgriLife Research; USDA
   National Institute of Food and Agriculture grant [1010958]; National
   Institutes of Health [R01 DK095118, R01DK124588, R01 DK120968]; American
   Diabetes Association Career Development Award [1-15-CD-09]; Texas A&M
   University Health Science Center and AgriLife Research; USDA National
   Institute of Food and Agriculture grant [1010958]
FX This work was supported by National Institutes of Health grants (R01
   DK095118, R01DK124588, and R01 DK120968), the American Diabetes
   Association Career Development Award (1-15-CD-09), faculty start-up
   funds from Texas A & M University Health Science Center and AgriLife
   Research, and a USDA National Institute of Food and Agriculture grant
   (Hatch 1010958) to Shaodong Guo.
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NR 244
TC 21
Z9 22
U1 3
U2 19
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD NOV
PY 2023
VL 15
IS 21
AR 4671
DI 10.3390/nu15214671
PG 23
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA X7SM2
UT WOS:001100403000001
PM 37960324
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Filipovic, B
   Lukic, S
   Mijac, D
   Marjanovic-Haljilji, M
   Vojnovic, M
   Bogdanovic, J
   Glisic, T
   Filipovic, N
   Al Kiswani, J
   Djokovic, A
   Kapor, S
   Kapor, S
   Bukumiric, Z
   Starcevic, A
AF Filipovic, Branka
   Lukic, Snezana
   Mijac, Dragana
   Marjanovic-Haljilji, Marija
   Vojnovic, Marko
   Bogdanovic, Jelena
   Glisic, Tijana
   Filipovic, Natasa
   Al Kiswani, Jamal
   Djokovic, Aleksandra
   Kapor, Suncica
   Kapor, Slobodan
   Bukumiric, Zoran
   Starcevic, Ana
TI The New Therapeutic Approaches in the Treatment of Non-Alcoholic Fatty
   Liver Disease
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE non-alcoholic fatty liver disease; lipotoxicity; organelle dysfunction;
   dysbiosis; new therapeutic modalities
ID GUT MICROBIOTA; CARDIOVASCULAR EVENTS; VITAMIN-E; STEATOHEPATITIS;
   PLACEBO; PIOGLITAZONE; DYSBIOSIS; IMPACT; NASH; LIPOTOXICITY
AB Non-alcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease which is characterized by extremely complex pathogenetic mechanisms and multifactorial etiology. Some of the many pathophysiological mechanisms involved in the development of NAFLD include oxidative stress, impaired mitochondrial metabolism, inflammation, gut microbiota, and interaction between the brain-liver-axis and the regulation of hepatic lipid metabolism. The new therapeutic approaches in the treatment of NAFLD are targeting some of these milestones along the pathophysiological pathway and include drugs like agonists of peroxisome proliferator-activated receptors (PPARs), glucagon-like peptide-1 (GLP-1) agonists, sodium/glucose transport protein 2 (SGLT2) inhibitors, farnesoid X receptor (FXR) agonists, probiotics, and symbiotics. Further efforts in biomedical sciences should focus on the investigation of the relationship between the microbiome, liver metabolism, and response to inflammation, systemic consequences of metabolic syndrome.
C1 [Filipovic, Branka; Lukic, Snezana; Mijac, Dragana; Bogdanovic, Jelena; Glisic, Tijana; Djokovic, Aleksandra; Kapor, Slobodan; Bukumiric, Zoran; Starcevic, Ana] Univ Belgrade, Fac Med, Dr Subotica Starijeg 8, Belgrade 11000, Serbia.
   [Filipovic, Branka; Marjanovic-Haljilji, Marija; Filipovic, Natasa; Al Kiswani, Jamal] Clin & Hosp Ctr Dr Dragisa Misovic Dedinje, Dept Gastroenterol, Heroja Milana Tepica 1, Belgrade 11020, Serbia.
   [Lukic, Snezana; Mijac, Dragana; Vojnovic, Marko; Glisic, Tijana] Clin Ctr Serbia, Clin Gastroenterol & Hepatol, Koste Todorovica 2, Belgrade 11000, Serbia.
   [Bogdanovic, Jelena] Clin Ctr Serbia, Clin Endocrinol Diabet & Metab Dis, Dr Subot 13, Belgrade 11000, Serbia.
   [Djokovic, Aleksandra] Clin & Hosp Ctr Bezanijska Kosa, Dept Cardiol, Dr Zorza Matea S-N, Belgrade 11080, Serbia.
   [Kapor, Suncica] Clin & Hosp Ctr Dr Dragisa Misovic Dedinje, Dept Hematol, Heroja Milana Tepica 1, Belgrade 11020, Serbia.
   [Kapor, Slobodan; Starcevic, Ana] Inst Anat Niko Miljan, Dr Subotica Starijeg 4-2, Belgrade 11000, Serbia.
   [Bukumiric, Zoran] Univ Belgrade, Fac Med, Inst Med Stat & Informat, Belgrade 11000, Serbia.
C3 University of Belgrade; Clinical Centre of Serbia; Clinical Centre of
   Serbia; University of Belgrade
RP Filipovic, B (corresponding author), Univ Belgrade, Fac Med, Dr Subotica Starijeg 8, Belgrade 11000, Serbia.; Filipovic, B (corresponding author), Clin & Hosp Ctr Dr Dragisa Misovic Dedinje, Dept Gastroenterol, Heroja Milana Tepica 1, Belgrade 11020, Serbia.
EM branka.filipovic3@gmail.com; lukic.snezana@gmail.com; drsaska@yahoo.com;
   maja-s-92@hotmail.com; marko.vojna@gmail.com; jeca.bogdanovic@yahoo.com;
   tijana.glisic78@gmail.com; filipovicn@live.com; jamalkiswani@gmail.com;
   drsaska@yahoo.com; suncicabjelica@gmail.com; kaporbg@gmail.com;
   zoran.bukumiric@med.bg.ac.rs; ana.starcevic22@gmail.com
RI Djokovic, Aleksandra/ISU-9092-2023; Starcevic, Ana/HLX-6059-2023; Kapor,
   Suncica/HOA-5178-2023; Djokovic, Aleksandra/G-1591-2017
OI Kapor, Slobodan/0000-0002-6695-6393; Glisic, Tijana/0000-0002-6242-7275;
   Lukic, Snezana/0000-0002-4646-1131; Bogdanovic,
   Jelena/0000-0002-4921-171X; Starcevic, Ana/0000-0003-2117-4213;
   Bukumiric, Zoran/0000-0002-7609-4504; Djokovic,
   Aleksandra/0000-0002-6094-7306; Mijac, Dragana/0000-0002-9386-4056
FU Ministry of Education, Science and Technological Development, Government
   of the Republic of Serbia [III 41020]
FX FundingThe investigation was partially financed by the grant of the
   Ministry of Education, Science and Technological Development, Government
   of the Republic of Serbia, no. III 41020.
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NR 124
TC 31
Z9 33
U1 2
U2 13
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD DEC
PY 2021
VL 22
IS 24
AR 13219
DI 10.3390/ijms222413219
PG 17
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA XZ8CW
UT WOS:000737876100001
PM 34948020
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Perico, L
   Morigi, M
   Benigni, A
AF Perico, Luca
   Morigi, Marina
   Benigni, Ariela
TI Mitochondrial Sirtuin 3 and Renal Diseases
SO NEPHRON
LA English
DT Review
DE Sirtuin 3; Mitochondria; Renal diseases
ID ACUTE KIDNEY INJURY; CARDIAC-HYPERTROPHY; LONGEVITY; DEACETYLATES;
   STRESS; BLOCKS; CELLS; MPTP; MICE
AB Mitochondria are dynamic organelles whose functions are tightly regulated at multiple levels to maintain proper cellular homeostasis. Mitochondrial Sirtuin 3 (SIRT3), which belongs to an evolutionary conserved family of NAD(+)-dependent deacetylases, is a key regulator of the mitochondrial respiratory chain, ATP production, and fatty acid beta-oxidation, and it exerts an antioxidant activity. Changes in SIRT3 expression are critical in the pathophysiology of several diseases, such as metabolic syndrome, diabetes, cancer, and aging. In experimental acute kidney injury (AKI), impairment of renal function and development of tubular injury are associated with SIRT3 reduction and mitochondrial dysfunction in proximal tubuli. SIRT3-deficient mice are more susceptible to AKI and die. Pharmacological manipulations able to increase SIRT3 preserve mitochondrial integrity, markedly limit renal injury, and accelerate functional recovery. This review highlights all the selective rescue mechanisms that point to the key role of SIRT3 as a new therapeutic target for curing renal diseases. (C) 2016 S. Karger AG, Basel
C1 [Perico, Luca; Morigi, Marina; Benigni, Ariela] IRCCS Ist Ric Farmacol Mario Negri, Anna Maria Astori Ctr, Kilometro Rosso Sci & Technol Pk,Via Stezzano 87, IT-24126 Bergamo, Italy.
C3 Istituto di Ricerche Farmacologiche Mario Negri IRCCS
RP Perico, L (corresponding author), IRCCS Ist Ric Farmacol Mario Negri, Anna Maria Astori Ctr, Kilometro Rosso Sci & Technol Pk,Via Stezzano 87, IT-24126 Bergamo, Italy.
EM luca.perico@marionegri.it
RI Perico, Luca/ABH-3224-2020; Morigi, Marina/ABH-3131-2020; Ariela,
   Benigni/ABH-3492-2020
OI Morigi, Marina/0000-0001-8029-7382; Benigni, Ariela/0000-0002-4721-5485;
   Perico, Luca/0000-0003-3470-1721
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NR 32
TC 60
Z9 67
U1 0
U2 10
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1660-8151
EI 2235-3186
J9 NEPHRON
JI Nephron
PY 2016
VL 134
IS 1
BP 14
EP 19
DI 10.1159/000444370
PG 6
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA DW1RT
UT WOS:000383421000004
PM 27362524
DA 2025-06-11
ER

PT J
AU Okovityi, SV
   Rad'ko, SV
   Shustov, EB
AF Okovityi, S. V.
   Rad'ko, S. V.
   Shustov, E. B.
TI 4 SUCCINATE RECEPTORS (SUCNR1) AS A POTENTIAL TARGET FOR PHARMACOTHERAPY
SO PHARMACEUTICAL CHEMISTRY JOURNAL
LA English
DT Article
DE GPR91 receptors; SUCNR1 receptors; succinate; reamberin
ID PROTEIN-COUPLED RECEPTORS; RENIN RELEASE; HIGH GLUCOSE; GPR91; ACID;
   DEFICIENCY; KIDNEY; CELLS; BINDS
AB A considerable number of reports have been published in recent years on G protein-coupled receptors, their distribution in the body, mechanism of activation, and potential pathways for pharmacological actions. Intermediates in carbohydrate, fat, and protein metabolism and the tricarboxylic acid cycle, operating as endogenous ligands for a large group of ex-orphan receptors, have active roles in regulating metabolic processes, while their synthetic analogs, operating as both agonists and antagonists, may have potential for the development of new pharmaceuticals for a wide range of diseases (diabetes mellitus, obesity, metabolic syndrome, autoimmune disorders, hypertension, myocardial hypertrophy and ischemia, neurodegenerative processes, liver diseases, etc.). The present review addresses GPR91 (SUCNR1) receptors, which have been identified in fatty tissue, liver, kidneys, heart, brain, retinal neurons, dendritic cells, and platelets, and which are regarded as physiological regulators and cell sensors for stress-induced damage and hypoxia.
C1 [Okovityi, S. V.; Rad'ko, S. V.] Minist Hlth Russian Federat, St Petersburg Chemicopharmaceut Acad, 14A Prof Popov St, St Petersburg, Russia.
   [Shustov, E. B.] Fed Med Biol Agcy Russian Federat, Sci Ctr Biomed Technol, Annex 1, Moscow 143442, Russia.
C3 Ministry of Health of the Russian Federation
RP Okovityi, SV (corresponding author), Minist Hlth Russian Federat, St Petersburg Chemicopharmaceut Acad, 14A Prof Popov St, St Petersburg, Russia.
RI Okovityi, Sergey/AAW-4856-2021; Okovityy, Sergey/Q-5122-2018
OI Okovityy, Sergey/0000-0003-4294-5531
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NR 39
TC 3
Z9 5
U1 0
U2 22
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0091-150X
EI 1573-9031
J9 PHARM CHEM J+
JI Pharm. Chem. J.
PD DEC
PY 2015
VL 49
IS 9
BP 573
EP 577
DI 10.1007/s11094-015-1331-8
PG 5
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA DB3TH
UT WOS:000368434100001
DA 2025-06-11
ER

PT J
AU Samino, S
   Vinaixa, M
   Díaz, M
   Beltran, A
   Rodríguez, MA
   Mallol, R
   Heras, M
   Cabre, A
   Garcia, L
   Canela, N
   de Zegher, F
   Correig, X
   Ibáñez, L
   Yanes, O
AF Samino, Sara
   Vinaixa, Maria
   Diaz, Marta
   Beltran, Antoni
   Rodriguez, Miguel A.
   Mallol, Roger
   Heras, Mercedes
   Cabre, Anna
   Garcia, Lorena
   Canela, Nuria
   de Zegher, Francis
   Correig, Xavier
   Ibanez, Lourdes
   Yanes, Oscar
TI Metabolomics reveals impaired maturation of HDL particles in adolescents
   with hyperinsulinaemic androgen excess
SO SCIENTIFIC REPORTS
LA English
DT Article
ID POLYCYSTIC-OVARY-SYNDROME; DENSITY-LIPOPROTEIN FUNCTION; CHOLESTEROL
   EFFLUX CAPACITY; OXIDATIVE STRESS; CARDIOVASCULAR-DISEASE; CAROTID
   ATHEROSCLEROSIS; METHIONINE OXIDATION; INSULIN-RESISTANCE;
   DIABETES-MELLITUS; SYNDROME PCOS
AB Hyperinsulinaemic androgen excess (HIAE) in prepubertal and pubertal girls usually precedes a broader pathological phenotype in adulthood that is associated with anovulatory infertility, metabolic syndrome and type 2 diabetes. The metabolic derangements that determine these long-term health risks remain to be clarified. Here we use NMR and MS-based metabolomics to show that serum levels of methionine sulfoxide in HIAE girls are an indicator of the degree of oxidation of methionine-148 residue in apolipoprotein-A1. Oxidation of apo-A1 in methionine-148, in turn, leads to an impaired maturation of high-density lipoproteins (HDL) that is reflected in a decline of large HDL particles. Notably, such metabolic alterations occur in the absence of impaired glucose tolerance, hyperglycemia and hypertriglyceridemia, and were partially restored after 18 months of treatment with a low-dose combination of pioglitazone, metformin and flutamide.
C1 [Samino, Sara; Vinaixa, Maria; Diaz, Marta; Beltran, Antoni; Rodriguez, Miguel A.; Mallol, Roger; Heras, Mercedes; Cabre, Anna; Correig, Xavier; Ibanez, Lourdes; Yanes, Oscar] Spanish Biomed Res Ctr Diabet & Associated Metab, Madrid 28029, Spain.
   [Vinaixa, Maria; Mallol, Roger; Correig, Xavier; Yanes, Oscar] Univ Rovira & Virgili, Dept Elect Engn, E-43007 Tarragona, Spain.
   [Samino, Sara; Vinaixa, Maria; Beltran, Antoni; Rodriguez, Miguel A.; Garcia, Lorena; Canela, Nuria; Yanes, Oscar] Univ Rovira & Virgili, COS, Reus 43204, Spain.
   [Heras, Mercedes; Cabre, Anna] Univ Rovira & Virgili, St Joan Univ Hosp, Res Unit Lipids & Atherosclerosis, IISPV, E-43201 Reus, Spain.
   [Diaz, Marta; Ibanez, Lourdes] Univ Barcelona, Hosp St Joan de Deu, Endocrinol Unit, Barcelona 08950, Spain.
   [de Zegher, Francis] Univ Leuven, Univ Hosp Gasthuisberg, Paediat Endocrinol, B-3000 Leuven, Belgium.
C3 Universitat Rovira i Virgili; Universitat Rovira i Virgili; Universitat
   Rovira i Virgili; Institut d'Investigacio Sanitaria Pere Virgili
   (IISPV); University of Barcelona; KU Leuven; University Hospital Leuven
RP Ibáñez, L (corresponding author), Spanish Biomed Res Ctr Diabet & Associated Metab, C Monforte de Lemos 3-5, Madrid 28029, Spain.
EM oscar.yanes@urv.cat
RI Vinaixa, Maria/AAB-1176-2020; Rodríguez-Gómez, Miguel/L-4942-2014;
   Vinaixa Crevillent, Maria/L-7236-2014; Yanes, Oscar/N-3630-2016;
   Correig, Xavier/K-9836-2014; Canela, Nuria/I-5401-2015; Ibanez,
   Lourdes/F-8316-2014
OI Ibanez, Lourdes/0000-0003-4595-7191; Heras,
   Mercedes/0000-0002-5285-154X; Vinaixa Crevillent,
   Maria/0000-0001-9804-0171; Mallol, Roger/0000-0001-5374-1580; Yanes,
   Oscar/0000-0003-3695-7157; Correig, Xavier/0000-0002-6902-3054; Samino,
   Sara/0000-0001-8371-679X; Canela, Nuria/0000-0003-0261-2396; Ibanez,
   Lourdes/0000-0002-5058-1603; Diaz, Marta/0000-0001-8775-7927;
   Rodriguez-Gomez, Miguel Angel/0000-0001-9568-9821
FU Spanish Biomedical Research Centre in Diabetes and Associated Metabolic
   Disorders (CIBERDEM); initiative of Instituto de Investigacion Carlos
   III (ISCIII); Fondo Europeo de Desarrollo Regional (FEDER) (Madrid,
   Spain); Spanish Ministry of Economy and Competitiveness [SAF2011-30578,
   PI09/90444]
FX We thank Dr. Carles Lerin and Dr. Pablo Garcia-Roves for helpful
   discussions. We thank the financial support from the Spanish Biomedical
   Research Centre in Diabetes and Associated Metabolic Disorders
   (CIBERDEM), an initiative of Instituto de Investigacion Carlos III
   (ISCIII), the Fondo Europeo de Desarrollo Regional (FEDER) (Madrid,
   Spain), and the Spanish Ministry of Economy and Competitiveness grants
   SAF2011-30578 (to OY) and PI09/90444 (to LI).
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NR 60
TC 15
Z9 15
U1 0
U2 36
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD JUN 23
PY 2015
VL 5
AR 11496
DI 10.1038/srep11496
PG 12
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA CL0WG
UT WOS:000356663200001
PM 26099471
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Adams, ST
   Salhab, M
   Hussain, ZI
   Miller, GV
   Leveson, SH
AF Adams, Simon Timothy
   Salhab, Mohamed
   Hussain, Zeiad Ihsan
   Miller, Glenn V.
   Leveson, Stephen H.
TI Obesity-related hypertension and its remission following gastric bypass
   surgery - A review of the mechanisms and predictive factors
SO BLOOD PRESSURE
LA English
DT Review
DE obesity; hypertension; gastric bypass
ID SYMPATHETIC-NERVE ACTIVITY; BODY-MASS-INDEX; BLOOD-PRESSURE;
   WEIGHT-LOSS; OXIDATIVE STRESS; INTRAABDOMINAL PRESSURE;
   ARTERIAL-PRESSURE; ANGIOTENSIN-II; SYSTEMIC HYPERTENSION; METABOLIC
   SYNDROME
AB It is well established that hypertension and obesity appear to be associated. The exact mechanism by which they are linked is unclear and remains a topic of a great deal of research. Current NICE guidelines recommend that patients with a BMI in excess of 35 kg/m(2) should be considered for bariatric surgery if they have a concomitant obesity-associated condition, of which hypertension is one. The commonest bariatric procedure in the UK is the Roux-en-Y gastric bypass, which has been shown to result in long-standing remission of hypertension in up to 93% of patients. This paper summarizes the existing literature on the main theories as to how obesity leads to hypertension as well as the literature concerning the effects of gastric bypass surgery on hypertension.
C1 [Adams, Simon Timothy; Salhab, Mohamed; Hussain, Zeiad Ihsan; Miller, Glenn V.; Leveson, Stephen H.] York Hosp, Dept Gen Surg, York YO31 8HE, N Yorkshire, England.
RP Adams, ST (corresponding author), York Hosp, Dept Gen Surg, Wigginton Rd, York YO31 8HE, N Yorkshire, England.
EM rpbgt@hotmail.com
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NR 89
TC 20
Z9 21
U1 0
U2 18
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0803-7051
EI 1651-1999
J9 BLOOD PRESSURE
JI Blood Pressure
PD JUN
PY 2013
VL 22
IS 3
BP 131
EP 137
DI 10.3109/08037051.2012.749570
PG 7
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 142OP
UT WOS:000318807100002
PM 23244451
OA Bronze
DA 2025-06-11
ER

PT J
AU Noble, JM
   Mandel, A
   Patterson, MC
AF Noble, James McCallum
   Mandel, Arthur
   Patterson, Marc C.
TI Scurvy and rickets masked by chronic neurologic illness: Revisiting
   "psychologic malnutrition"
SO PEDIATRICS
LA English
DT Article
DE scurvy; autistic spectrum disorder; vitamin D deficiency; malnutrition;
   hypocalcemia
ID VITAMIN-D STATUS; NUTRITIONAL RICKETS; ADOLESCENTS; PREVALENCE;
   CHILDREN; BOY; DEFICIENCY; OVERWEIGHT; BEHAVIORS; ADULTS
AB The North American epidemic of overeating, combined with a sedentary lifestyle, has led to a growing prevalence of obesity, diabetes, and the " metabolic syndrome" in children. Excessive caloric intake does not imply adequate nutrition, and vitamin- deficiency syndromes still occur in some American children. Here we describe cases of scurvy and vitamin D deficiency in 2 children with cognitive disorders. Thorough dietary histories suggested the diagnosis in each patient and, had they been obtained at presentation, would likely have obviated invasive diagnostic workup, unnecessary stress to the patients and their families, and significant functional disability. Overnutrition and malnutrition may coexist, particularly among those with abnormal cognition or autistic spectrum disorders. Classic nutritional deficiencies must not be omitted from the differential diagnosis. A comprehensive dietary history and screening for vitamin deficiencies in at- risk children are important aspects of preventive health care and are essential for prompt diagnosis and treatment.
C1 Columbia Univ, Med Ctr, Dept Neurol, Neurol Inst New York, New York, NY 10032 USA.
   Morgan Stanley Childrens Hosp, Dept Neurol, New York, NY USA.
   Morgan Stanley Childrens Hosp, Dept Pediat, New York, NY USA.
C3 Columbia University; NewYork-Presbyterian Hospital; Morgan Stanley
   Children's Hospital; NewYork-Presbyterian Hospital; Morgan Stanley
   Children's Hospital
RP Noble, JM (corresponding author), Columbia Univ, Med Ctr, Dept Neurol, Neurol Inst New York, 710 W 168th St, New York, NY 10032 USA.
EM jn2054@columbia.edu
RI Patterson, Marc/H-5331-2019; Noble, James/AAA-4218-2020
OI Noble, James/0000-0003-0648-6702; Patterson, Marc/0000-0002-1116-126X
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NR 43
TC 36
Z9 37
U1 0
U2 7
PU AMER ACAD PEDIATRICS
PI ELK GROVE VILLAGE
PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA
SN 0031-4005
EI 1098-4275
J9 PEDIATRICS
JI Pediatrics
PD MAR
PY 2007
VL 119
IS 3
BP E783
EP E790
DI 10.1542/peds.2006-1071
PG 8
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA 141LK
UT WOS:000244579800079
PM 17332193
DA 2025-06-11
ER

PT J
AU Mendes, FD
   Lindor, KD
AF Mendes, FD
   Lindor, KD
TI Recent advances in the treatment of non-alcoholic fatty liver disease
SO EXPERT OPINION ON INVESTIGATIONAL DRUGS
LA English
DT Review
DE drug therapy; fatty liver; non-alcoholic steatohepatitis
ID NECROSIS-FACTOR-ALPHA; VITAMIN-E TREATMENT; INSULIN-RESISTANCE;
   HEPATOCELLULAR-CARCINOMA; CRYPTOGENIC CIRRHOSIS; URSODEOXYCHOLIC ACID;
   NATURAL-HISTORY; WEIGHT-LOSS; TNF-ALPHA; STEATOHEPATITIS
AB Non-alcoholic steatohepatitis is a liver disease strongly associated with features of the metabolic syndrome. it is part of the disease spectrum of nonalcoholic fatty liver disease, which is now thought to be the most common cause of chronic liver disease in the US and other Western countries. Initially this condition was considered innocuous but it is now recognised as having the potential to progress to cirrhosis and its complications. The role of insulin resistance and oxidative stress in its pathogenesis is increasingly accepted. Current investigations are directed towards a better understanding of the natural history, pathogenesis and development of treatment strategies. Several therapeutic modalities, including antioxidants, insulin-sensitising agents and lipid-lowering agents, have been evaluated for the treatment of these patients, mostly in small clinical trials. Despite promising results, no therapy has demonstrated a proven benefit.
C1 Mayo Clin, Coll Med, Rochester, MN 55905 USA.
C3 Mayo Clinic
RP Mayo Clin, Coll Med, 200 1st St SW, Rochester, MN 55905 USA.
EM mendes.flavia@mayo.edu
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NR 61
TC 7
Z9 32
U1 0
U2 2
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1354-3784
EI 1744-7658
J9 EXPERT OPIN INV DRUG
JI Expert Opin. Investig. Drugs
PD JAN
PY 2005
VL 14
IS 1
BP 29
EP 35
DI 10.1517/13543784.14.1.29
PG 7
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 888UL
UT WOS:000226399600003
PM 15709919
DA 2025-06-11
ER

PT J
AU Lee, SJ
   Oh, BK
   Sung, KC
AF Lee, Seung Jae
   Oh, Byeong Kil
   Sung, Ki-Chul
TI Uric acid and cardiometabolic diseases
SO CLINICAL HYPERTENSION
LA English
DT Review
DE Uric acid; Cardiometabolic disease; Cardiovascular disease; Metabolic
   syndrome
ID XANTHINE-OXIDASE INHIBITION; CORONARY-ARTERY-DISEASE; CHRONIC
   HEART-FAILURE; FATTY LIVER-DISEASE; ALL-CAUSE MORTALITY; SERUM
   ANTIOXIDANT CAPACITY; ATRIAL-FIBRILLATION; INSULIN-RESISTANCE;
   CARDIOVASCULAR MORTALITY; INDEPENDENT PREDICTOR
AB Hyperuricemia, which has been considered as a cause of gout and nephrolithiasis has recently been suggested to be associated with hypertension, coronary heart disease, heart failure, atrial fibrillation, insulin resistance, and nonalcoholic fatty liver disease. Several clinical and experimental studies have supported uric acid (UA) as an independent risk factor for predicting disease development along with the traditional risk factors. The mechanism by which UA causes cardiometabolic disease has not been fully elucidated to date; however, it has been explained by several hypotheses such as oxidative stress, reduced nitric oxide bioavailability, inflammation, endothelial dysfunction, and so on. Although evidence of the preventive and therapeutic effects of UA lowering therapy on cardiometabolic diseases is still insufficient, it is expected to be considered as a new treatment strategy for such diseases through additional, carefully designed, large-scale clinical studies.
C1 [Lee, Seung Jae; Oh, Byeong Kil; Sung, Ki-Chul] Sungkyunkwan Univ, Sch Med, Kangbuk Samsung Hosp, Div Cardiol,Dept Internal Med, 29 Saemunan Ro, Seoul 03181, South Korea.
C3 Sungkyunkwan University (SKKU)
RP Sung, KC (corresponding author), Sungkyunkwan Univ, Sch Med, Kangbuk Samsung Hosp, Div Cardiol,Dept Internal Med, 29 Saemunan Ro, Seoul 03181, South Korea.
EM kcmd.sung@samsung.com
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NR 111
TC 46
Z9 48
U1 0
U2 9
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
EI 2056-5909
J9 CLIN HYPERTENS
JI Clin. Hypertens.
PD JUN 15
PY 2020
VL 26
IS 1
AR 13
DI 10.1186/s40885-020-00146-y
PG 7
WC Peripheral Vascular Disease
WE Emerging Sources Citation Index (ESCI)
SC Cardiovascular System & Cardiology
GA WE1BO
UT WOS:000705363300001
PM 32549999
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Ge, L
   Yang, M
   Yang, NN
   Yin, XX
   Song, WG
AF Ge, Li
   Yang, Ming
   Yang, Na-Na
   Yin, Xin-Xin
   Song, Wen-Gang
TI Molecular hydrogen: a preventive and therapeutic medical gas for various
   diseases
SO ONCOTARGET
LA English
DT Review
DE molecular hydrogen; selective anti-oxidation; gaseous signal modulator;
   preventive and therapeutic applications
ID RICH SALINE PROTECTS; ISCHEMIA-REPERFUSION INJURY; ACUTE KIDNEY INJURY;
   TRAUMATIC BRAIN-INJURY; ACUTE LUNG INJURY; NF-KAPPA-B; OXIDATIVE-STRESS;
   RAT MODEL; ISCHEMIA/REPERFUSION INJURY; WATER PROTECTS
AB Since the 2007 discovery that molecular hydrogen (H-2) has selective antioxidant properties, multiple studies have shown that H-2 has beneficial effects in diverse animal models and human disease. This review discusses H-2 biological effects and potential mechanisms of action in various diseases, including metabolic syndrome, organ injury, and cancer; describes effective H-2 delivery approaches; and summarizes recent progress toward H-2 applications in human medicine. We also discuss remaining questions in H-2 therapy, and conclude with an appeal for a greater role for H-2 in the prevention and treatment of human ailments that are currently major global health burdens. This review makes a case for supporting hydrogen medicine in human disease prevention and therapy.
C1 [Ge, Li] Taishan Med Univ, Sch Basic Med Sci, Dept Histol & Embryol, Tai An 271000, Shandong, Peoples R China.
   [Yang, Ming; Yin, Xin-Xin] Taishan Med Univ, Dept Clin Med, Tai An 271000, Shandong, Peoples R China.
   [Yang, Na-Na] Taishan Med Univ, Univ Shandong, Key Lab Atherosclerosis, Inst Atherosclerosis, Tai An 271000, Shandong, Peoples R China.
   [Song, Wen-Gang] Taishan Med Univ, Sch Basic Med Sci, Dept Med Immunol, Tai An 271000, Shandong, Peoples R China.
C3 Taishan University; Shandong First Medical University & Shandong Academy
   of Medical Sciences; Shandong First Medical University & Shandong
   Academy of Medical Sciences; Taishan University; Shandong First Medical
   University & Shandong Academy of Medical Sciences; Shandong University;
   Taishan University; Shandong First Medical University & Shandong Academy
   of Medical Sciences
RP Song, WG (corresponding author), Taishan Med Univ, Sch Basic Med Sci, Dept Med Immunol, Tai An 271000, Shandong, Peoples R China.
EM s.com@163.com
RI Yang, Ming/GYE-1251-2022
FU National Natural Science Foundation of China [81401246, 81600360,
   81771711]; College Scientific Project of Shandong Province [J16LK02];
   National Science and Technology Major Projects [2014ZX09508003]; Science
   and Technology Development Project of Shandong Province [2014GSF118044]
FX This work was supported by grants from the National Natural Science
   Foundation of China [grant number 81401246, 81600360, 81771711], the
   College Scientific Project of Shandong Province [grant number J16LK02],
   the National Science and Technology Major Projects [grant number
   2014ZX09508003], and the Science and Technology Development Project of
   Shandong Province [grant number 2014GSF118044].
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NR 249
TC 136
Z9 146
U1 6
U2 66
PU IMPACT JOURNALS LLC
PI ORCHARD PARK
PA 6666 E QUAKER ST, STE 1, ORCHARD PARK, NY 14127 USA
EI 1949-2553
J9 ONCOTARGET
JI Oncotarget
PD NOV 24
PY 2017
VL 8
IS 60
BP 102653
EP 102673
DI 10.18632/oncotarget.21130
PG 21
WC Oncology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Cell Biology
GA FS1JX
UT WOS:000419533200141
PM 29254278
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Pulido-Moran, M
   Moreno-Fernandez, J
   Ramirez-Tortosa, C
   Ramirez-Tortosa, MC
AF Pulido-Moran, Mario
   Moreno-Fernandez, Jorge
   Ramirez-Tortosa, Cesar
   Ramirez-Tortosa, M. Carmen
TI Curcumin and Health
SO MOLECULES
LA English
DT Review
DE curcumin; bioavailability; antioxidant; ROS; anti-inflammatory; cancer;
   lung diseases; liver disorders; cardiovascular diseases; natural
   compound
ID NF-KAPPA-B; CHEMOPREVENTIVE AGENT CURCUMIN; ALLERGIC AIRWAY
   INFLAMMATION; INDUCED LIPID-PEROXIDATION; INDUCED PULMONARY-FIBROSIS;
   GLUTATHIONE-S-TRANSFERASE; HUMAN COLORECTAL-CANCER;
   TUMOR-NECROSIS-FACTOR; I CLINICAL-TRIAL; OXIDATIVE STRESS
AB Nowadays, there are some molecules that have shown over the years a high capacity to act against relevant pathologies such as cardiovascular disease, neurodegenerative disorders or cancer. This article provides a brief review about the origin, bioavailability and new research on curcumin and synthetized derivatives. It examines the beneficial effects on health, delving into aspects such as cancer, cardiovascular effects, metabolic syndrome, antioxidant capacity, anti-inflammatory properties, and neurological, liver and respiratory disorders. Thanks to all these activities, curcumin is positioned as an interesting nutraceutical. This is the reason why it has been subjected to several modifications in its structure and administration form that have permitted an increase in bioavailability and effectiveness against different diseases, decreasing the mortality and morbidity associated to these pathologies.
C1 [Pulido-Moran, Mario; Ramirez-Tortosa, M. Carmen] Univ Granada, Dept Bioquim & Biol Mol 2, Fac Farm, Campus Univ Cartuja, E-18071 Granada, Spain.
   [Pulido-Moran, Mario; Moreno-Fernandez, Jorge; Ramirez-Tortosa, M. Carmen] Univ Granada, Ctr Invest Biomed, Inst Nutr & Tecnol Alimentos Jose Mataix Vedru, Ave Conocimiento S-N, Armilla 18016, Granada, Spain.
   [Moreno-Fernandez, Jorge] Univ Granada, Fac Farm, Dept Fisiol, Campus Univ Cartuja, E-18071 Granada, Spain.
   [Ramirez-Tortosa, Cesar] Complejo Hosp Jaen, Serv Anat Patol, Jaen 23007, Spain.
C3 University of Granada; University of Granada; University of Granada;
   Complejo Hospitalario de Jaen
RP Ramirez-Tortosa, MC (corresponding author), Univ Granada, Dept Bioquim & Biol Mol 2, Fac Farm, Campus Univ Cartuja, E-18071 Granada, Spain.; Ramirez-Tortosa, MC (corresponding author), Univ Granada, Ctr Invest Biomed, Inst Nutr & Tecnol Alimentos Jose Mataix Vedru, Ave Conocimiento S-N, Armilla 18016, Granada, Spain.
EM mpulido@ugr.es; jorgemf@correo.ugr.es;
   cesarl.ramirez.sspa@juntadeandalucia.es; mramirez@ugr.es
RI Moreno-Fernandez, Jorge/L-2793-2017; Ramirez-Tortosa, Cesar/F-2055-2016
OI Moreno-Fernandez, Jorge/0000-0001-9690-7851; Ramirez-Tortosa,
   Cesar/0000-0002-3302-707X; Ramirez Tortosa, Maria
   Carmen/0000-0002-7999-0881
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NR 222
TC 413
Z9 441
U1 14
U2 170
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1420-3049
J9 MOLECULES
JI Molecules
PD MAR
PY 2016
VL 21
IS 3
AR 264
DI 10.3390/molecules21030264
PG 22
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA DI9DR
UT WOS:000373802200113
PM 26927041
OA Green Published, gold, Green Submitted
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Wang, WY
   Du, LX
   Wei, QD
   Lu, MY
   Xu, DH
   Li, Y
AF Wang, Wenyu
   Du, Lixin
   Wei, Qidong
   Lu, Mengyao
   Xu, Dehong
   Li, Ya
TI Synthesis and Health Effects of Phenolic Compounds: A Focus on Tyrosol,
   Hydroxytyrosol, and 3,4-Dihydroxyacetophenone
SO ANTIOXIDANTS
LA English
DT Review
DE tyrosol; hydroxytyrosol; 3,4-dihydroxyacetophenone; mechanism of action
ID VIRGIN OLIVE OIL; CELL-CYCLE ARREST; HIGH-FAT DIET; OXIDATIVE STRESS;
   ENDOTHELIAL DYSFUNCTION; METABOLIC SYNDROME; CEREBRAL-ISCHEMIA;
   WASTE-WATER; DNA-DAMAGE; IN-VIVO
AB Tyrosol (Tyr), hydroxytyrosol (TH), and 3,4-Dihydroxyacetophenone (3,4-DHAP) are three phenolic compounds naturally present in plants that have attracted considerable research attention due to their potent antioxidant, anti-inflammatory, anticancer, and cardiovascular protective properties. In recent years, mounting evidence has indicated that these phenolic compounds hold broad potential in both disease prevention and treatment. This paper reviews the chemical structures and synthetic methods of Tyr, HT, and 3,4-DHAP, as well as their multifaceted effects on human health, particularly their roles and mechanisms in antioxidation, anti-inflammation, cardiovascular protection, neuroprotection, and anticancer activity. In addition, this paper explores the future prospects of these compounds and the current challenges associated with their application-such as low bioavailability and long-term safety concerns-and proposes directions for further investigation.
C1 [Wang, Wenyu; Du, Lixin; Wei, Qidong; Lu, Mengyao; Xu, Dehong; Li, Ya] Hunan Univ Chinese Med, Sch Pharm, Changsha 410208, Peoples R China.
C3 Hunan University of Chinese Medicine
RP Xu, DH; Li, Y (corresponding author), Hunan Univ Chinese Med, Sch Pharm, Changsha 410208, Peoples R China.
EM 20233810@stu.hnucm.edu.cn; 20223723@stu.hnucm.edu.cn;
   20233763@stu.hnucm.edu.cn; 20243753@stu.hnucm.edu.cn;
   003971@hnucm.edu.cn; 003872@hnucm.edu.cn
FU Key Discipline Project on Chinese Pharmacology of Hunan University of
   Chinese Medicine; Scientific Research Topics of Hunan Provincial Health
   and Wellness Commission [D202303017861]; National Natural Science
   Foundation of China Project [82104324]; Hunan Provincial Natural Science
   Foundation General Project [2025JJ50100];  [202302]
FX Key Discipline Project on Chinese Pharmacology of Hunan University of
   Chinese Medicine (202302), Scientific Research Topics of Hunan
   Provincial Health and Wellness Commission (D202303017861), National
   Natural Science Foundation of China Project (82104324) and Hunan
   Provincial Natural Science Foundation General Project (2025JJ50100).
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NR 212
TC 0
Z9 0
U1 2
U2 2
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD APR 16
PY 2025
VL 14
IS 4
AR 476
DI 10.3390/antiox14040476
PG 27
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA 1VN1N
UT WOS:001474649300001
PM 40298838
OA gold
DA 2025-06-11
ER

PT J
AU Schwartz, P
   Capotondo, MM
   Quaintenne, M
   Musso-Enz, GM
   Aroca-Martinez, G
   Musso, CG
AF Schwartz, Paula
   Capotondo, Maria M.
   Quaintenne, Miranda
   Musso-Enz, Guido M.
   Aroca-Martinez, Gustavo
   Musso, Carlos G.
TI Obesity and glomerular filtration rate
SO INTERNATIONAL UROLOGY AND NEPHROLOGY
LA English
DT Review
DE Obesity; Glomerular filtration rate; Bariatric surgery
ID BARIATRIC SURGERY; EQUATIONS
AB Obesity has received considerable attention in general medicine and nephrology over the last few years. This condition increases the risk of metabolic syndrome, diabetes mellitus, hypertension, and dyslipidemia, which are the main risk factors for developing chronic kidney disease (CKD). Kidney damage caused by obesity can be explained by many mechanisms, such as sympathetic nervous and renin-angiotensin-aldosterone systems activation, mechanical stress, hormonal unbalance, as well as inflammatory cytokines production. Even though creatinine-based glomerular filtration rate (GFR) equations in obese individuals have been validated (Salazar-Corcoran and CKD-MCQ), changes in body weight after bariatric surgery (BS) leads to changes in creatininemia, affecting its reliability. Thus, an average between creatine and cystatin-based GFR equations would be more appropriate in this setting. Bariatric surgery can reverse diabetes mellitus and improve hypertension, which are the main causes of CKD. Conclusion: GFR can be affected by obesity and BS, and its value should be cautiously evaluated in this setting.
C1 [Schwartz, Paula; Capotondo, Maria M.] Hosp Italiano Buenos Aires, Internal Med Div, Buenos Aires, Argentina.
   [Quaintenne, Miranda; Musso, Carlos G.] Inst Univ Hosp Italiano Buenos Aires, Physiol Dept, Buenos Aires, Argentina.
   [Musso-Enz, Guido M.] Univ Catolica Argentina, Fac Med, Buenos Aires, Argentina.
   [Aroca-Martinez, Gustavo; Musso, Carlos G.] Univ Simon Bolivar, Fac Ciencias Salud, Barranquilla, Colombia.
C3 Hospital Italiano de Buenos Aires; University of Buenos Aires;
   University of Buenos Aires Hospital; Hospital Italiano de Buenos Aires;
   Pontificia Universidad Catolica Argentina
RP Musso, CG (corresponding author), Inst Univ Hosp Italiano Buenos Aires, Physiol Dept, Buenos Aires, Argentina.; Musso, CG (corresponding author), Univ Simon Bolivar, Fac Ciencias Salud, Barranquilla, Colombia.
EM carlos.musso@hospitalitaliano.org.ar
RI Aroca-Martínez, Gustavo/AAV-7952-2021; Aroca-Martinez,
   Gustavo/P-9173-2016
OI Musso, Carlos/0000-0001-8666-1130; Aroca-Martinez,
   Gustavo/0000-0002-9222-3257
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NR 35
TC 7
Z9 7
U1 0
U2 2
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0301-1623
EI 1573-2584
J9 INT UROL NEPHROL
JI Int. Urol. Nephrol.
PD MAY
PY 2024
VL 56
IS 5
BP 1663
EP 1668
DI 10.1007/s11255-023-03862-0
EA NOV 2023
PG 6
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA ND8R9
UT WOS:001100426900001
PM 37947985
DA 2025-06-11
ER

PT J
AU Garcia-Serrano, AM
   Duarte, JMN
AF Garcia-Serrano, Alba M.
   Duarte, Joao M. N.
TI Brain Metabolism Alterations in Type 2 Diabetes: What Did We Learn From
   Diet-Induced Diabetes Models?
SO FRONTIERS IN NEUROSCIENCE
LA English
DT Review
DE diet-induced obesity; brain metabolism; insulin resistance; glucose;
   sucrose; high-fat
ID HIGH-FAT DIET; INSULIN-RESISTANCE; ALZHEIMERS-DISEASE; MITOCHONDRIAL
   DYNAMICS; COGNITIVE IMPAIRMENT; INTRANASAL INSULIN; IN-VIVO;
   GLUCOSE-METABOLISM; ENERGY-METABOLISM; RAT-BRAIN
AB Type 2 diabetes (T2D) is a metabolic disease with impact on brain function through mechanisms that include glucose toxicity, vascular damage and blood-brain barrier (BBB) impairments, mitochondrial dysfunction, oxidative stress, brain insulin resistance, synaptic failure, neuroinflammation, and gliosis. Rodent models have been developed for investigating T2D, and have contributed to our understanding of mechanisms involved in T2D-induced brain dysfunction. Namely, mice or rats exposed to diabetogenic diets that are rich in fat and/or sugar have been widely used since they develop memory impairment, especially in tasks that depend on hippocampal processing. Here we summarize main findings on brain energy metabolism alterations underlying dysfunction of neuronal and glial cells promoted by diet-induced metabolic syndrome that progresses to a T2D phenotype.
C1 [Garcia-Serrano, Alba M.; Duarte, Joao M. N.] Lund Univ, Fac Med, Dept Expt Med Sci, Lund, Sweden.
   [Garcia-Serrano, Alba M.; Duarte, Joao M. N.] Lund Univ, Fac Med, Wallenberg Ctr Mol Med, Lund, Sweden.
C3 Lund University; Lund University
RP Duarte, JMN (corresponding author), Lund Univ, Fac Med, Dept Expt Med Sci, Lund, Sweden.; Duarte, JMN (corresponding author), Lund Univ, Fac Med, Wallenberg Ctr Mol Med, Lund, Sweden.
EM joao.duarte@med.lu.se
RI Garcia-Serrano, Alba/U-5101-2019; Duarte, Joao/H-4887-2012
OI Garcia-Serrano, Alba/0000-0002-0829-6403
FU Knut and Alice Wallenberg Foundation; Medical Faculty at Lund
   University; Region Skane; Swiss National Science Foundation (Ambizione
   grant) [148250]; Swedish Research Council [2019-01130]; Diabetesfonden
   [Dia2019-440]; Crafoord Foundation [20190007]; Direktor Albert Pahlssons
   Foundation [FB2018-0265, FB2019-0321]; Royal Physiographic Society in
   Lund; Anna-Lisa Rosenberg Foundation; Lars Hiertas Minne Foundation;
   Swedish Research Council [2019-01130] Funding Source: Swedish Research
   Council
FX The Knut and Alice Wallenberg Foundation, the Medical Faculty at Lund
   University, and Region Skane are acknowledged for generous financial
   support. The authors' research that is discussed in this review has been
   funded by the Swiss National Science Foundation (Ambizione grant
   148250), Swedish Research Council (2019-01130), Diabetesfonden
   (Dia2019-440), Crafoord Foundation (20190007), and Direktor Albert
   Pahlssons Foundation (FB2018-0265 and FB2019-0321), Royal Physiographic
   Society in Lund, Anna-Lisa Rosenberg Foundation, and Lars Hiertas Minne
   Foundation.
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NR 127
TC 63
Z9 64
U1 1
U2 17
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1662-453X
J9 FRONT NEUROSCI-SWITZ
JI Front. Neurosci.
PD MAR 20
PY 2020
VL 14
AR 229
DI 10.3389/fnins.2020.00229
PG 11
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA KZ7ZP
UT WOS:000523478800001
PM 32265637
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Lam, YY
   Peterson, CM
   Ravussin, E
AF Lam, Yan Y.
   Peterson, Courtney M.
   Ravussin, Eric
TI Resveratrol vs. calorie restriction: Data from rodents to humans
SO EXPERIMENTAL GERONTOLOGY
LA English
DT Article
DE Calorie restriction; Resveratrol; Energy metabolism; SIRT1; AMPK
ID INDUCED INSULIN-RESISTANCE; WHITE ADIPOSE-TISSUE; SKELETAL-MUSCLE;
   OXIDATIVE STRESS; LIFE-SPAN; MITOCHONDRIAL-FUNCTION;
   GLUCOSE-HOMEOSTASIS; DIETARY RESTRICTION; METABOLIC SYNDROME;
   ENERGY-METABOLISM
AB Calorie restriction extends lifespan and confers metabolic benefits similar to the effect of lifestyle interventions. Poor compliance to long-term dietary restriction, however, hinders the success of this approach. Evidence is now persuasive for a role of resveratrol supplementation (a polyphenol in red grapes) as potential alternative to calorie restriction. This review summarizes the latest literature on the effects and the molecular mechanisms by which calorie restriction and resveratrol confer health benefits. Resveratrol activates SIRT1 and the associated improvement in energy utilization and insulin sensitivity closely resembles the benefits of calorie restriction. Current data largely support resveratrol as a potential calorie restriction mimetic to improve metabolic and probably functional health. Future studies which characterize the bioavailability and efficacy of resveratrol supplementation are critical to provide evidence for its long-term health benefits. (C) 2013 Elsevier Inc. All rights reserved.
C1 [Lam, Yan Y.; Peterson, Courtney M.; Ravussin, Eric] Pennington Biomed Res Ctr, John S McIlhenny Skeletal Muscle Physiol Lab, Baton Rouge, LA 70808 USA.
C3 Louisiana State University System; Louisiana State University;
   Pennington Biomedical Research Center
RP Lam, YY (corresponding author), Pennington Biomed Res Ctr, John S McIlhenny Skeletal Muscle Physiol Lab, 6400 Perkins Rd, Baton Rouge, LA 70808 USA.
EM yan.lam@pbrc.edu; courtney.peterson@pbrc.edu; eric.ravussin@pbrc.edu
RI Ravussin, Eric/N-1985-2017
OI Ravussin, Eric/0000-0003-2129-547X
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NR 109
TC 55
Z9 59
U1 0
U2 76
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0531-5565
EI 1873-6815
J9 EXP GERONTOL
JI Exp. Gerontol.
PD OCT
PY 2013
VL 48
IS 10
BP 1018
EP 1024
DI 10.1016/j.exger.2013.04.005
PG 7
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA 213AZ
UT WOS:000324026600004
PM 23624181
DA 2025-06-11
ER

PT J
AU Charansonney, OL
   Després, JP
AF Charansonney, Olivier L.
   Despres, Jean-Pierre
TI Disease prevention-should we target obesity or sedentary lifestyle?
SO NATURE REVIEWS CARDIOLOGY
LA English
DT Article
ID TYPE-2 DIABETES-MELLITUS; BODY-MASS INDEX; PHYSICAL-ACTIVITY;
   CARDIOVASCULAR-DISEASE; CARDIORESPIRATORY FITNESS; METABOLIC SYNDROME;
   EXERCISE CAPACITY; HEALTHY-MEN; RISK; MORTALITY
AB Obesity is a major health challenge facing the modern world. Some evidence points to obesity itself as the main driver of premature mortality. We propose that this view is oversimplified. For example, high levels of physical activity and cardiorespiratory fitness are associated with lower mortality, even in those who are overweight or obese. To address this issue, we combine epidemiological and physiological evidence in a new paradigm that integrates excess calorie intake, sedentary behavior, and a maladaptive response to stress. Human physiology is optimized to allow large distances to be covered on foot every day in order to find enough food to sustain brain metabolism. Furthermore, when the body is immobilized by an injury, it triggers efficient life-saving metabolic and inflammatory responses. Both these critical adaptations are, however, confounded by a sedentary lifestyle. The implications of these issues for clinical trial design and epidemiologic data analysis are discussed in this article.
C1 [Charansonney, Olivier L.] Ctr Hosp Sud Francilien, Dept Cardiol, F-91108 Corbeil Essonnes, France.
   [Despres, Jean-Pierre] Univ Laval, Div Kinesiol, Dept Social & Prevent Med, Quebec City, PQ G1V 4G2, Canada.
C3 Centre Hospitalier Sud Francilien; Laval University
RP Charansonney, OL (corresponding author), Ctr Hosp Sud Francilien, Dept Cardiol, 59 Blvd Henri Dunant, F-91108 Corbeil Essonnes, France.
EM olivier.charansonney@orange.fr
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NR 33
TC 35
Z9 38
U1 0
U2 27
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 1759-5002
J9 NAT REV CARDIOL
JI Nat. Rev. Cardiol.
PD AUG
PY 2010
VL 7
IS 8
BP 468
EP 472
DI 10.1038/nrcardio.2010.68
PG 5
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 633SB
UT WOS:000280524200012
PM 20498671
DA 2025-06-11
ER

PT J
AU Watt, MJ
   Steinberg, GR
AF Watt, Matthew J.
   Steinberg, Gregory R.
TI Regulation and function of triacylglycerol lipases in cellular
   metabolism
SO BIOCHEMICAL JOURNAL
LA English
DT Review
DE adipose tissue; adipose triacylglycerol lipase (ATGL); fatty acid
   metabolism; hormone-sensitive lipase (HSL); obesity; skeletal muscle;
   Type 2 diabetes
ID HORMONE-SENSITIVE LIPASE; ADIPOSE TRIGLYCERIDE LIPASE; ACID-BINDING
   PROTEIN; FAMILIAL COMBINED HYPERLIPIDEMIA; HEPATIC INSULIN SENSITIVITY;
   MUSCLE LIPID-METABOLISM; ALPHA-INDUCED LIPOLYSIS; HUMAN SKELETAL-MUSCLE;
   FREE FATTY-ACIDS; TNF-ALPHA
AB The ability to store energy in the form of energy-dense TAG (triacylglycerol) and to mobilize these stores rapidly during times of low carbohydrate availability (fasting or famine) or during heightened metabolic demand (exercise or cold-stress) is a highly conserved process essential for survival. today, in the presence of nutrient excess and sedentary lifestyles, the regulation of this pathway is viewed as an important therapeutic target for disease prevention, as elevated circulating fatty acids in obesity contribute to many aspects of the metabolic syndrome including hepatic steatosis, atherosclerosis and insulin resistance. In the present review, we discuss the metabolic regulation and function of TAG lipases with a focus on HSL (hormone-sensitive lipase) ATGL (adipose triacylglycerol lipase) and newly identified members of the lipolytic proteome.
C1 [Steinberg, Gregory R.] Univ Melbourne, St Vincents Inst, Melbourne, Vic 3065, Australia.
   [Steinberg, Gregory R.] Univ Melbourne, Dept Med, Melbourne, Vic 3065, Australia.
   [Watt, Matthew J.] Monash Univ, Dept Physiol, Clayton, Vic 3800, Australia.
C3 University of Melbourne; St. Vincent's Institute of Medical Research;
   University of Melbourne; Monash University
RP Steinberg, GR (corresponding author), Univ Melbourne, St Vincents Inst, Melbourne, Vic 3065, Australia.
EM gsteinberg@svi.edu.au
RI Steinberg, Greg/ACI-2304-2022; Watt, Matthew/B-2089-2014
OI Steinberg, Gregory/0000-0001-5425-8275
FU R. Douglas Wright Fellowship; National Health and Medical Research
   Council of Australia
FX M.J.W. is supported by an R. Douglas Wright Fellowship, and G.R.S. is
   supported by a Senior Research Fellowship from the National Health and
   Medical Research Council of Australia.
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NR 156
TC 127
Z9 153
U1 0
U2 23
PU PORTLAND PRESS LTD
PI LONDON
PA 5TH FLR, 90 HIGH HOLBORN, LONDON WC1V 6LJ, ENGLAND
SN 0264-6021
EI 1470-8728
J9 BIOCHEM J
JI Biochem. J.
PD SEP 15
PY 2008
VL 414
BP 313
EP 325
DI 10.1042/BJ20080305
PN 3
PG 13
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 352QP
UT WOS:000259512500001
PM 18717647
DA 2025-06-11
ER

PT J
AU Wang, SN
   Jin, ZH
   Wu, BY
   Morris, AJ
   Deng, P
AF Wang, Shengnan
   Jin, Zihui
   Wu, Biyu
   Morris, Andrew J.
   Deng, Pan
TI Role of dietary and nutritional interventions in ceramide-associated
   diseases
SO JOURNAL OF LIPID RESEARCH
LA English
DT Review
DE ceramide; dietary intervention; cardiometabolic disease; neurological
   disease; autoimmune; cancer
ID HEALTHY NORDIC DIET; PLASMA CERAMIDES; INSULIN SENSITIVITY; METABOLIC
   SYNDROME; OXIDATIVE STRESS; CARDIOVASCULAR-DISEASE; ACID
   SPHINGOMYELINASE; ALZHEIMERS-DISEASE; WALNUT CONSUMPTION; MEDITERRANEAN
   DIET
AB Ceramides are important intermediates in sphingolipid metabolism and serve as signaling molecules with independent biological significance. Elevated cellular and circulating ceramide levels are consistently associated with pathological conditions including cardiometabolic diseases, neurological diseases, autoimmune diseases, and cancers. Although pharmacological inhibition of ceramide formation often protects against these diseases in animal models, pharmacological modulation of ceramides in humans remains impractical. Dietary interventions including the Mediterranean diet, lacto-ovovegetarian diet, calorie-restricted diet, restriction of dairy product consumption, and dietary supplementation with polyunsaturated fatty acids, dietary fibers, and polyphenols, all have beneficial effects on modulating ceramide levels. Mechanistic insights into these interventions are discussed. This article reviews the relationships between ceramides and disease pathogenesis, with a focus on dietary intervention as a viable strategy for lowering the concentration of circulating ceramides.
C1 [Wang, Shengnan; Jin, Zihui; Wu, Biyu; Deng, Pan] Soochow Univ, Jiangsu Key Lab Neuropsychiat Dis, Suzhou, Jiangsu, Peoples R China.
   [Wang, Shengnan; Jin, Zihui; Wu, Biyu; Deng, Pan] Soochow Univ, Coll Pharmaceut Sci, Suzhou, Jiangsu, Peoples R China.
   [Morris, Andrew J.] Univ Arkansas Med Sci, Dept Pharmacol & Toxicol, Little Rock, AR USA.
   [Morris, Andrew J.] Cent Arkansas Vet Affairs Healthcare Syst, Little Rock, AR USA.
C3 Soochow University - China; Soochow University - China; University of
   Arkansas System; University of Arkansas Medical Sciences; US Department
   of Veterans Affairs; Veterans Health Administration (VHA); Central
   Arkansas Veterans Healthcare System
RP Deng, P (corresponding author), Soochow Univ, Jiangsu Key Lab Neuropsychiat Dis, Suzhou, Jiangsu, Peoples R China.; Deng, P (corresponding author), Soochow Univ, Coll Pharmaceut Sci, Suzhou, Jiangsu, Peoples R China.
EM pandeng@suda.edu.cn
RI Deng, Pan/F-3026-2012; Wang, Shengnan/ITU-3655-2023
OI Morris, Andrew/0000-0003-1910-4865; Deng, Pan/0000-0003-2974-7389
FU National Natural Science Foundation of China [82373942]; Priority
   Ac-ademic Program Development of Jiangsu Higher Education Institutes
   (PAPD); Suzhou International Joint Lab-oratory for Diagnosis and
   Treatment of Brain Diseases
FX Acknowledgments This work was supported by the National Natural Science
   Foundation of China (grant no.: 82373942) , the Priority Ac-ademic
   Program Development of Jiangsu Higher Education Institutes (PAPD) , and
   the Suzhou International Joint Lab-oratory for Diagnosis and Treatment
   of Brain Diseases.
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NR 215
TC 1
Z9 1
U1 15
U2 15
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0022-2275
EI 1539-7262
J9 J LIPID RES
JI J. Lipid Res.
PD JAN
PY 2025
VL 66
IS 1
AR 100726
DI 10.1016/j.jlr.2024.100726
EA JAN 2025
PG 19
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA T2Q3I
UT WOS:001403513300001
PM 39667580
OA Green Published
DA 2025-06-11
ER

PT J
AU Silva, LF
   Ravi, R
   Vangipurapu, J
   Laakso, M
AF Fernandes Silva, Lilian
   Ravi, Rowmika
   Vangipurapu, Jagadish
   Laakso, Markku
TI Metabolite Signature of Simvastatin Treatment Involves Multiple
   Metabolic Pathways
SO METABOLITES
LA English
DT Article
DE simvastatin; metabolomics; metabolites
ID GLOBAL BIOCHEMICAL APPROACH; CORONARY-HEART-DISEASE; INSULIN
   SENSITIVITY; CHOLESTEROL; INHIBITION; SECRETION; SYNTHASE; CHOLINE;
   BETAINE; STRESS
AB Statins inhibit the 3-hydroxy-3-methylglutaryl-CoA reductase enzyme and are the most widely used medication for hypercholesterolemia. Previous studies on the metabolite signature of simvastatin treatment have included only a small number of metabolites. We performed a high-throughput liquid chromatography-tandem mass spectroscopy profiling on the effects of simvastatin treatment on 1098 metabolite concentrations in the participants of the METSIM (Metabolic Syndrome In Men) study including 1332 participants with simvastatin treatment and 6200 participants without statin treatment. We found that simvastatin exerts profound pleiotropic effects on different metabolite pathways, affecting not only lipids, but also amino acids, peptides, nucleotides, carbohydrates, co-factors, vitamins, and xenobiotics. We identified 321 metabolites significantly associated with simvastatin treatment, and 313 of these metabolites were novel. Our study is the first comprehensive evaluation of the metabolic signature of simvastatin treatment in a large population-based study.
C1 [Fernandes Silva, Lilian; Ravi, Rowmika; Vangipurapu, Jagadish; Laakso, Markku] Univ Eastern Finland, Inst Clin Med, Internal Med, Kuopio 70210, Finland.
   [Laakso, Markku] Kuopio Univ Hosp, Dept Med, Kuopio 70210, Finland.
C3 University of Eastern Finland; Kuopio University Hospital; University of
   Eastern Finland; University of Eastern Finland Hospital
RP Laakso, M (corresponding author), Univ Eastern Finland, Inst Clin Med, Internal Med, Kuopio 70210, Finland.; Laakso, M (corresponding author), Kuopio Univ Hosp, Dept Med, Kuopio 70210, Finland.
EM markku.laakso@uef.fi
RI Ravi, Rowmika/LRC-1462-2024
OI Fernandes Silva, Lilian/0000-0003-0225-842X; Ravi,
   Rowmika/0000-0001-7994-8547
FU Academy of Finland [0245896-3]; Sigrid Juselius Foundation; Finnish
   Foundation for Cardiovascular Research; Centre of Excellence of
   Cardiovascular and Metabolic Diseases - Academy of Finland [0245896-3]
FX The METSIM study was supported by grants from the Academy of Finland
   (321428), Sigrid Juselius Foundation, Finnish Foundation for
   Cardiovascular Research, and Centre of Excellence of Cardiovascular and
   Metabolic Diseases supported by the Academy of Finland (0245896-3)
   (M.L.).
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NR 53
TC 12
Z9 13
U1 0
U2 11
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2218-1989
J9 METABOLITES
JI Metabolites
PD AUG
PY 2022
VL 12
IS 8
AR 753
DI 10.3390/metabo12080753
PG 11
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 4C8DN
UT WOS:000846676800001
PM 36005625
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Manieri, E
   Folgueira, C
   Rodríguez, ME
   Leiva-Vega, L
   Esteban-Lafuente, L
   Chen, CB
   Cubero, FJ
   Barrett, T
   Cavanagh-Kyros, J
   Seruggia, D
   Rosell, A
   Sanchez-Cabo, F
   Gómez, MJ
   Monte, MJ
   Marin, JJG
   Davis, RJ
   Mora, A
   Sabio, G
AF Manieri, Elisa
   Folgueira, Cintia
   Elena Rodriguez, Maria
   Leiva-Vega, Luis
   Esteban-Lafuente, Laura
   Chen, Chaobo
   Javier Cubero, Francisco
   Barrett, Tamera
   Cavanagh-Kyros, Julie
   Seruggia, Davide
   Rosell, Alejandro
   Sanchez-Cabo, Fatima
   Jose Gomez, Manuel
   Monte, Maria J.
   Marin, Jose J. G.
   Davis, Roger J.
   Mora, Alfonso
   Sabio, Guadalupe
TI JNK-mediated disruption of bile acid homeostasis promotes intrahepatic
   cholangiocarcinoma
SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF
   AMERICA
LA English
DT Article
DE JNK; PPARa; bile acid; cholangiocarcinoma
ID ACTIVATED RECEPTOR-ALPHA; PPAR-ALPHA; HEPATOCELLULAR-CARCINOMA; FATTY
   LIVER; PROLIFERATION; EXPRESSION; GROWTH; CELL; FENOFIBRATE; METABOLISM
AB Metabolic stress causes activation of the cJun NH2-terminal kinase (JNK) signal transduction pathway. It is established that one con-sequence of JNK activation is the development of insulin resistance and hepatic steatosis through inhibition of the transcription factor PPAR alpha. Indeed, JNK1/2 deficiency in hepatocytes protects against the development of steatosis, suggesting that JNK inhibition repre-sents a possible treatment for this disease. However, the long-term consequences of JNK inhibition have not been evaluated. Here we demonstrate that hepatic JNK controls bile acid production. We found that hepatic JNK deficiency alters cholesterol metabolism and bile acid synthesis, conjugation, and transport, resulting in cholestasis, increased cholangiocyte proliferation, and intrahepatic cholangiocarcinoma. Gene ablation studies confirmed that PPAR alpha mediated these effects of JNK in hepatocytes. This analysis highlights potential consequences of long-term use of JNK inhibitors for the treatment of metabolic syndrome.
C1 [Manieri, Elisa; Folgueira, Cintia; Elena Rodriguez, Maria; Leiva-Vega, Luis; Esteban-Lafuente, Laura; Rosell, Alejandro; Sanchez-Cabo, Fatima; Jose Gomez, Manuel; Mora, Alfonso; Sabio, Guadalupe] Ctr Nacl Invest Cardiovasc, Myocardial Pathophysiol Area, Madrid 28029, Spain.
   [Manieri, Elisa] CSIC, Dept Immunol & Oncol, Ctr Nacl Biotecnol, Madrid 28049, Spain.
   [Chen, Chaobo; Javier Cubero, Francisco] Univ Complutense Madrid, Dept Immunol Ophthalmol & ENT, Sch Med, Madrid 28040, Spain.
   [Barrett, Tamera; Cavanagh-Kyros, Julie; Davis, Roger J.] Univ Massachusetts, Program Mol Med, Med Sch, Worcester, MA 01605 USA.
   [Seruggia, Davide] Harvard Med Sch, Boston Childrens Hosp, Dana Farber Canc Inst, Div Hematol Oncol, Boston, MA 02215 USA.
   [Monte, Maria J.; Marin, Jose J. G.] Univ Salamanca, Natl Inst Study Liver & Gastrointestinal Dis CIBE, Lab Expt Hepatol & Drug Targeting, Salamanca 37007, Spain.
C3 Centro Nacional de Investigaciones Cardiovasculares (CNIC); Consejo
   Superior de Investigaciones Cientificas (CSIC); CSIC - Centro Nacional
   de Biotecnologia (CNB); Complutense University of Madrid; University of
   Massachusetts System; University of Massachusetts Worcester; Harvard
   University; Harvard University Medical Affiliates; Boston Children's
   Hospital; Harvard Medical School; Dana-Farber Cancer Institute;
   University of Salamanca
RP Mora, A; Sabio, G (corresponding author), Ctr Nacl Invest Cardiovasc, Myocardial Pathophysiol Area, Madrid 28029, Spain.; Davis, RJ (corresponding author), Univ Massachusetts, Program Mol Med, Med Sch, Worcester, MA 01605 USA.
EM roger.davis@umassmed.edu; amora@cnic.es; guadalupe.sabio@cnic.es
RI seruggia, davide/T-9574-2019; Manieri, Elisa/AAM-4706-2021;
   Sanchez-Cabo, Fatima/IZD-8966-2023; Mora, Alfonso/D-2759-2017;
   Folgueira, Cintia/AAB-6964-2019; Sanchez-Cabo, Fatima/N-5030-2014;
   Sabio, Guadalupe/H-9733-2015; Marin, Jose/D-5017-2011; Monte, Maria
   J/A-9529-2017; chaobo, chen/X-6937-2019; Gomez, Manuel J/F-8854-2016
OI Manieri, Elisa/0000-0002-7525-019X; Sanchez-Cabo,
   Fatima/0000-0003-1881-1664; seruggia, davide/0000-0001-5014-0499; Sabio,
   Guadalupe/0000-0002-2822-0625; Marin, Jose/0000-0003-1186-6849; Monte,
   Maria J/0000-0003-1844-7428; chaobo, chen/0000-0001-5963-5295;
   Folgueira, Cintia/0000-0003-3803-9149; Cavanagh Kyros,
   Julie/0000-0001-7003-516X; Davis, Roger/0000-0002-0130-1652; Rosell
   Jimenez, Alejandro/0000-0001-8028-8144; Mora,
   Alfonso/0000-0002-6397-4836; Gomez, Manuel J/0000-0002-4111-4835
FU La Caixa fellowship [RYC-2009-04972, RYC-2014-15242]; European Regional
   Development Fund [CD19/00078]; EU [260464]; EFSD/Lilly European Diabetes
   Research Programme Dr. Sabio; Leonardo Grant for Researchers and
   Cultural Creators, BBVA Foundation; MINECO-FEDER [SAF2016-79126-R];
   Comunidad de Madrid; La Asociacion Espanola contra el Cancer
   [IMMUNOTHERCAN-CM S2010/BMD-2326, B2017/BMD-3733]; European Cooperation
   in Science & Technology (COST) Action [CA17112]; MINECO Retos; AMMF
   Cholangiocarcinoma Charity [SAF2016-78711]; NIH [2018/117, NanoLiver-CM
   Y2018/NMT-4949, UCM-25-2019, DK R01 DK107220]; Carlos III Institute of
   Health, Spain [PI16/00598]; Ministerio de Ciencia, Innovacion y
   Universidades; Pro-CNIC Foundation;  [SEV-2015-0505]
FX We thank S. Bartlett for English editing and David Garlick (University
   of Massachusetts Medical School) for pathological examination of tissue
   sections. We are grateful to the CNIC Advanced Imaging and Animal
   facility for technical support. G.S. (RYC-2009-04972) and F.J.C.
   (RYC-2014-15242) are investigators of the Ramon y Cajal Program. E.M.
   was awarded a La Caixa fellowship. C.F. was awarded a Sara Borrell
   contract (CD19/00078). This work was funded by grants supported in part
   by funds from the European Regional Development Fund: EU's Seventh
   Framework Programme (FP7/2007-2013) ERC 260464, EFSD/Lilly European
   Diabetes Research Programme Dr. Sabio, 2017 Leonardo Grant for
   Researchers and Cultural Creators, BBVA Foundation
   (Investigadores-BBVA-2017) IN[17]_BBM_BAS_0066, MINECO-FEDER
   SAF2016-79126-R, and Comunidad de Madrid IMMUNOTHERCAN-CM S2010/BMD-2326
   and B2017/BMD-3733 and La Asociacion Espanola contra el Cancer (to
   G.S.); EXOHEP-CM S2017/BMD-3727 and the European Cooperation in Science
   & Technology (COST) Action CA17112 (to F.J.C.); MINECO Retos
   SAF2016-78711, the AMMF Cholangiocarcinoma Charity 2018/117,
   NanoLiver-CM Y2018/NMT-4949, UCM-25-2019, ERAB EA/18-14 (to F.J.C.).
   F.J.C. is a Gilead Liver Research Scholar. Grant DK R01 DK107220 from
   the NIH (to R.J.D.); and PI16/00598 from Carlos III Institute of Health,
   Spain (to J.J.G.M.). The CNIC is supported by the Ministerio de Ciencia,
   Innovacion y Universidades, and the Pro-CNIC Foundation and is a Severo
   Ochoa Center of Excellence (SEV-2015-0505).
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NR 53
TC 45
Z9 47
U1 1
U2 16
PU NATL ACAD SCIENCES
PI WASHINGTON
PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA
SN 0027-8424
J9 P NATL ACAD SCI USA
JI Proc. Natl. Acad. Sci. U. S. A.
PD JUL 14
PY 2020
VL 117
IS 28
BP 16492
EP 16499
DI 10.1073/pnas.2002672117
PG 8
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA MR0MR
UT WOS:000553288300002
PM 32601222
OA Green Submitted, Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Sugimoto, K
   Takei, Y
AF Sugimoto, Kazushi
   Takei, Yoshiyuki
TI Clinicopathological features of non-alcoholic fatty liver disease
SO HEPATOLOGY RESEARCH
LA English
DT Review
DE epidemiology pathogenesis; non-alcoholic fatty liver disease
ID PLACEBO-CONTROLLED TRIAL; DIET-INDUCED OBESITY;
   HEPATOCELLULAR-CARCINOMA; INSULIN-RESISTANCE; HEPATIC STEATOSIS;
   NATURAL-HISTORY; CRYPTOGENIC CIRRHOSIS; ADIPONECTIN RECEPTORS; LEPTIN
   RECEPTOR; ADIPOSE-TISSUE
AB Non-alcoholic fatty liver disease (NAFLD) is the most common form of chronic liver disease worldwide and its incidence is increasing concomitantly with the increase in the prevalence of metabolic syndrome. Fatty liver encompasses a broad pathological spectrum of disease, from relatively benign accumulation of fat (simple steatosis) to progressive nonalcoholic steatohepatitis (NASH), which is associated with necroinflammation and fibrosis. Approximately 20-30% of the Japanese population is estimated to have NAFLD, 10% of which is suggested to have NASH. The most worrisome feature of NASH is the potential progression to cirrhosis, hepatocellular carcinoma (HCC), and finally, mortality. Several factors, such as insulin resistance, adipokines, endotoxins and oxidative stress, are involved in the pathogenesis of NASH. However, the precise etiological mechanism of NAFLD/NASH has yet to be elucidated. This article reviews the clinical background, pathogenesis, new diagnostic approaches and future directions regarding NAFLD/NASH.
C1 [Sugimoto, Kazushi; Takei, Yoshiyuki] Mie Univ, Sch Med, Dept Gastroenterol & Hepatol, Tsu, Mie 5148507, Japan.
C3 Mie University
RP Sugimoto, K (corresponding author), Mie Univ, Sch Med, Dept Gastroenterol & Hepatol, 2-174 Edobashi, Tsu, Mie 5148507, Japan.
EM kazushi@clin.medic.mie-u.ac.jp
FU Grants-in-Aid for Scientific Research [21590839] Funding Source: KAKEN
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NR 95
TC 21
Z9 24
U1 0
U2 8
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1386-6346
EI 1872-034X
J9 HEPATOL RES
JI Hepatol. Res.
PD OCT
PY 2011
VL 41
IS 10
BP 911
EP 920
DI 10.1111/j.1872-034X.2011.00867.x
PG 10
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 824SU
UT WOS:000295223200001
PM 21951869
DA 2025-06-11
ER

PT J
AU D'Souza, A
   Hussain, M
   Howarth, FC
   Woods, NM
   Bidasee, K
   Singh, J
AF D'Souza, Alicia
   Hussain, Munir
   Howarth, Frank C.
   Woods, Niall M.
   Bidasee, Keshore
   Singh, Jaipaul
TI Pathogenesis and pathophysiology of accelerated atherosclerosis in the
   diabetic heart
SO MOLECULAR AND CELLULAR BIOCHEMISTRY
LA English
DT Review
DE Diabetes mellitus; Coronary artery disease; Hyperglycemia; Endothelial
   dysfunction
ID NITRIC-OXIDE SYNTHASE; CORONARY-ARTERY-DISEASE; PROTEIN-KINASE-C;
   ENDOTHELIAL PROGENITOR CELLS; INSULIN-RESISTANCE; OXIDATIVE STRESS;
   ADVANCED GLYCATION; METABOLIC SYNDROME; VASCULAR-DISEASE;
   CARDIOVASCULAR-DISEASE
AB It has been established that atherosclerotic coronary artery disease is more frequent and more severe in diabetic compared to non-diabetic subjects, but the reason for the excess risk of developing coronary macroangiopathy in diabetes remains incompletely characterized. Various biochemical mechanisms speculated to being at the "heart" of diabetic cardiac and coronary macroangiopathy are reviewed in the present article. In doing so, this article presents evidence that the labyrinthine interactions of hyperglycemia, insulin resistance, and dyslipidemia in diabetes result in a pro-atherogenic phenotype. Furthermore, the diabetic milieu yields a complex (dys)metabolic environment characterized by chronic inflammation, procoagulability, impaired fibrinolysis, neovascularization abnormalities, and microvascular defects that cumulatively alter blood rheology, artery structure, and homeostasis of the endothelium. The contributory influences of these factors in the pathophysiology of coronary artery disease in diabetes are also discussed.
C1 [D'Souza, Alicia; Woods, Niall M.; Singh, Jaipaul] Univ Cent Lancashire, Sch Forens & Invest Sci, Preston PR1 2HE, Lancs, England.
   [Hussain, Munir] Univ Bradford, Div Biomed Sci, Bradford BD7 1DP, W Yorkshire, England.
   [Howarth, Frank C.] United Arab Emirates Univ, Dept Physiol, Fac Med & Hlth Sci, Al Ain, U Arab Emirates.
   [Bidasee, Keshore] Univ Nebraska Med Ctr, Dept Pharmacol & Expt Neurosci, Nebraska Med Ctr 98500, Omaha, NE USA.
C3 University of Central Lancashire; University of Bradford; United Arab
   Emirates University; University of Nebraska System; University of
   Nebraska Medical Center
RP Singh, J (corresponding author), Univ Cent Lancashire, Sch Forens & Invest Sci, Preston PR1 2HE, Lancs, England.
EM jsingh3@uclan.ac.uk
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NR 173
TC 43
Z9 49
U1 0
U2 8
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0300-8177
EI 1573-4919
J9 MOL CELL BIOCHEM
JI Mol. Cell. Biochem.
PD NOV
PY 2009
VL 331
IS 1-2
BP 89
EP 116
DI 10.1007/s11010-009-0148-8
PG 28
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA 513FN
UT WOS:000271308000012
PM 19466528
DA 2025-06-11
ER

PT J
AU Longui, CA
   Faria, CDC
AF Longui, Carlos Alberto
   Costantin Faria, Claudia Dutra
TI Evaluation of Glucocorticoid Sensitivity and Its Potential Clinical
   Applicability
SO HORMONE RESEARCH
LA English
DT Review
DE Glucocorticoid sensitivity; Glucocorticoid receptor; Dexamethasone
   suppression test
ID DEXAMETHASONE-SUPPRESSION TEST; RECEPTOR ALPHA-ISOFORM;
   MOLECULAR-MECHANISMS; RHEUMATOID-ARTHRITIS; IN-VIVO; GENE; EXPRESSION;
   RESISTANCE; CORTISOL; POLYMORPHISMS
AB Glucocorticoids (GC) play an important role in physiologic and pathophysiologic adaptive responses to stress. The majority of these effects are mediated by the GC receptors (GR). GC sensitivity largely depends of the amount of available GR, and their ability to bind the GC-responsive element and/or other nuclear transcription factors, leading to modulation of the expression of GC target genes. Clinical conditions of tissue-specific GC resistance or GC hypersensitivity have been described in several diseases, such as chronic inflammatory and autoimmune conditions, and in visceral obesity, such as metabolic syndrome. Several in vivo and in vitro methods have been described, allowing the evaluation and quantitation of GC sensitivity. The recognition of these parameters has improved our comprehension of the mechanisms involved in those diseases, with potential implications for the diagnosis and therapy of such abnormalities. Copyright (C) 2009 S. Karger AG, Basel
C1 [Longui, Carlos Alberto; Costantin Faria, Claudia Dutra] Pediat Dept Irmandade Santa Casa Misericordia Sao, Pediat Endocrinol Unit, Sao Paulo, Brazil.
   [Longui, Carlos Alberto] Fac Med Sci Santa Casa Sao Pauol, Dept Physiol, Mol Med Lab, Sao Paulo, Brazil.
RP Longui, CA (corresponding author), Rua Prof Artur Ramos 96,20 Andar Jardim Paulistan, BR-01454010 Sao Paulo, Brazil.
EM carloslongui@msn.com
RI Longui, Carlos/B-8112-2013
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NR 41
TC 15
Z9 15
U1 0
U2 2
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0301-0163
J9 HORM RES
JI Horm. Res.
PY 2009
VL 71
IS 6
BP 305
EP 309
DI 10.1159/000223413
PG 5
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 462RF
UT WOS:000267372700001
PM 19506386
OA Bronze
DA 2025-06-11
ER

PT J
AU Molnár, AA
   Birgés, K
   Surman, A
   Merkely, B
AF Molnar, Andrea agnes
   Birges, Kristof
   Surman, Adrienn
   Merkely, Bela
TI The Complex Connection Between Myocardial Dysfunction and Cancer Beyond
   Cardiotoxicity: Shared Risk Factors and Common Molecular Pathways
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE myocardial dysfunction; cancer; molecular pathways
ID RENIN-ANGIOTENSIN SYSTEM; TUMOR-NECROSIS-FACTOR; HEART-FAILURE;
   CARDIOVASCULAR-DISEASE; INFLAMMATORY RESPONSE; METABOLIC SYNDROME;
   OXIDATIVE STRESS; CELL-MIGRATION; BLOOD-PRESSURE; DNA-DAMAGE
AB Cardiovascular diseases and cancer represent the largest disease burden worldwide. Previously, these two conditions were considered independent, except in terms of cardiotoxicity, which links cancer treatment to subsequent cardiovascular issues. However, recent studies suggest that there are further connections between cancer and heart disease beyond cardiotoxicity. It has been revealed that myocardial dysfunction may promote carcinogenesis, indicating that additional common pathophysiological mechanisms might be involved in the relationship between cardiology and oncology, rather than simply a connection through cardiotoxic effects. These mechanisms may include shared risk factors and common molecular pathways, such as persistent inflammation and neurohormonal activation. This review explores the connection between myocardial dysfunction and cancer, emphasizing their shared risk factors, similar biological mechanisms, and causative factors like cardiotoxicity, along with their clinical implications.
C1 [Molnar, Andrea agnes; Birges, Kristof; Surman, Adrienn; Merkely, Bela] Semmelweis Univ, Heart & Vasc Ctr, H-1122 Budapest, Hungary.
C3 Semmelweis University
RP Molnár, AA (corresponding author), Semmelweis Univ, Heart & Vasc Ctr, H-1122 Budapest, Hungary.
EM molnar.andrea@semmelweis.hu; birgeskristof@gmail.com;
   drsurmana@gmail.com; merkely.bela@gmail.com
OI Merkely, Bela/0000-0001-6514-0723; Surman, Adrienn/0009-0005-7539-2381
FU European Union;  [RRF-2.3.1-21-2022-00003]
FX Project no. RRF-2.3.1-21-2022-00003 has been implemented with the
   support provided by the European Union.
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NR 187
TC 0
Z9 0
U1 3
U2 3
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD DEC
PY 2024
VL 25
IS 23
AR 13185
DI 10.3390/ijms252313185
PG 23
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA P2P2W
UT WOS:001376388700001
PM 39684895
OA gold
DA 2025-06-11
ER

PT J
AU Li, C
   Yang, J
   Wang, Y
   Qi, YZ
   Yang, WQ
   Li, YL
AF Li, Chao
   Yang, Jie
   Wang, Yu
   Qi, Yingzi
   Yang, Wenqing
   Li, Yunlun
TI Farnesoid X Receptor Agonists as Therapeutic Target for Cardiometabolic
   Diseases
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Review
DE Farnesoid X Receptor; cardiometabolic diseases; lipid metabolism;
   diabetes mellitus; obesity
ID FATTY LIVER-DISEASE; ENDOPLASMIC-RETICULUM STRESS; BILE-ACID METABOLISM;
   FXR AGONIST; CARDIOVASCULAR-DISEASE; NUCLEAR RECEPTOR;
   INSULIN-RESISTANCE; CHENODEOXYCHOLIC ACID; OBETICHOLIC ACID; ASYMMETRIC
   DIMETHYLARGININE
AB Cardiometabolic diseases are characterized as a combination of multiple risk factors for cardiovascular disease (CVD) and metabolic diseases including diabetes mellitus and dyslipidemia. Cardiometabolic diseases are closely associated with cell glucose and lipid metabolism, inflammatory response and mitochondrial function. Farnesoid X Receptor (FXR), a metabolic nuclear receptor, are found to be activated by primary BAs such as chenodeoxycholic acid (CDCA), cholic acid (CA) and synthetic agonists such as obeticholic acid (OCA). FXR plays crucial roles in regulating cholesterol homeostasis, lipid metabolism, glucose metabolism, and intestinal microorganism. Recently, emerging evidence suggests that FXR agonists are functional for metabolic syndrome and cardiovascular diseases and are considered as a potential therapeutic agent. This review will discuss the pathological mechanism of cardiometabolic disease and reviews the potential mechanisms of FXR agonists in the treatment of cardiometabolic disease.
C1 [Li, Chao; Yang, Wenqing; Li, Yunlun] Shandong Univ Tradit Chinese Med, Expt Ctr, Jinan, Peoples R China.
   [Yang, Jie; Wang, Yu; Li, Yunlun] Shandong Univ Tradit Chinese Med, Cardiovasc Dept, Affiliated Hosp, Jinan, Peoples R China.
   [Qi, Yingzi] Shandong Univ Tradit Chinese Med, Sch Hlth, Jinan, Peoples R China.
C3 Shandong University of Traditional Chinese Medicine; Shandong University
   of Traditional Chinese Medicine; Shandong University of Traditional
   Chinese Medicine
RP Yang, WQ; Li, YL (corresponding author), Shandong Univ Tradit Chinese Med, Expt Ctr, Jinan, Peoples R China.; Li, YL (corresponding author), Shandong Univ Tradit Chinese Med, Cardiovasc Dept, Affiliated Hosp, Jinan, Peoples R China.
EM wenqing-yang@hotmail.com; yunlun.lee@hotmail.com
RI Yang, Wenqing/F-7026-2011; Li, Chao/ABD-9324-2021
OI Li, Chao/0000-0003-1568-9704
FU National Nature Science Foundation of China [81774242, 81804006]; China
   Postdoctoral Science Foundation [2020M672125]; Major Science Natural
   Science Foundation of the Shandong Province [ZR2018ZC1157]; Taishan
   Scholar Post Construction Fund [ts201712042]
FX This work received support by National Nature Science Foundation of
   China (81774242, 81804006), China Postdoctoral Science Foundation
   (2020M672125), the Major Science Natural Science Foundation of the
   Shandong Province (ZR2018ZC1157), and Taishan Scholar Post Construction
   Fund (ts201712042).
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NR 172
TC 36
Z9 40
U1 0
U2 39
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD AUG 26
PY 2020
VL 11
AR 1247
DI 10.3389/fphar.2020.01247
PG 15
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA NP9ZC
UT WOS:000570527600001
PM 32982723
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Qi, J
   Luo, X
   Ma, ZC
   Zhang, B
   Li, SY
   Duan, XY
   Yang, B
   Zhang, J
AF Qi, Jie
   Luo, Xue
   Ma, Zhichao
   Zhang, Bo
   Li, Shuyan
   Duan, Xuyang
   Yang, Bo
   Zhang, Jun
TI Swimming Exercise Protects against Insulin Resistance via Regulating
   Oxidative Stress through Nox4 and AKT Signaling in High-Fat Diet-Fed
   Mice
SO JOURNAL OF DIABETES RESEARCH
LA English
DT Article
ID SKELETAL-MUSCLE; DNA-DAMAGE; AMPK; METABOLISM; INTENSITY; FIBROSIS;
   PATHWAY; GLUCOSE
AB Nonpharmaceutical therapies such as exercise training and diet intervention are widely used for the treatment of insulin resistance (IR). Although the skeletal muscle is the major peripheral tissue of glucose metabolism under insulin stimulation, the mechanism underlying muscle IR is poorly understood. Using a high-fat diet-induced IR mouse model, we here show that NADPH oxidase 4 (Nox4) upregulation mediates the production of reactive oxygen species (ROS) that causes metabolic syndrome featuring IR. The Nox4 expression level was markedly elevated in IR mice, and Nox4 overexpression was sufficient to trigger IR. Conversely, downregulation of Nox4 expression through exercise training prevented diet-induced IR by reducing the production of ROS and enhancing the AKT signaling pathway. Thus, this study indicates that exercise might improve IR through a reduction of Nox4-induced ROS in the skeletal muscle and enhancement of AKT signal transduction.
C1 [Qi, Jie; Zhang, Bo; Duan, Xuyang; Zhang, Jun] Shanghai Normal Univ, Coll Phys Educ, Shanghai 200234, Peoples R China.
   [Luo, Xue] Yangzhou Polytech Coll, Coll Med, Yangzhou 225009, Jiangsu, Peoples R China.
   [Ma, Zhichao] Wuhan Business Univ, Sch Phys Educ, Wuhan 430056, Hubei, Peoples R China.
   [Li, Shuyan] Yangzhou Univ, Coll Phys Educ, Yangzhou 225009, Jiangsu, Peoples R China.
   [Yang, Bo] Wenzhou Med Univ, Coll Publ Hlth & Management, Wenzhou 325000, Zhejiang, Peoples R China.
C3 Shanghai Normal University; Yangzhou Polytechnic Institute; Wuhan
   Business University; Yangzhou University; Wenzhou Medical University
RP Zhang, J (corresponding author), Shanghai Normal Univ, Coll Phys Educ, Shanghai 200234, Peoples R China.; Yang, B (corresponding author), Wenzhou Med Univ, Coll Publ Hlth & Management, Wenzhou 325000, Zhejiang, Peoples R China.
EM qijieyzu@126.com; 632903278@qq.com; mazhichaocn@live.cn;
   1036773545@qq.com; leeshuyan01@126.com; 1197618977@qq.com;
   hot-020@163.com; zhangjyzh@sina.com
RI Ma, Zhichao/MZR-7636-2025; duan, xuyang/LQK-5988-2024
FU National Natural Science Foundation of China [31701037]
FX We thank all of the research staff and students who assisted with animal
   sampling and provided technical support. This study was supported
   financially by the National Natural Science Foundation of China (Grant
   no. 31701037).
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NR 34
TC 15
Z9 15
U1 0
U2 7
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2314-6745
EI 2314-6753
J9 J DIABETES RES
JI J. Diabetes Res.
PD JAN 21
PY 2020
VL 2020
AR 2521590
DI 10.1155/2020/2521590
PG 9
WC Endocrinology & Metabolism; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Research & Experimental Medicine
GA KH8AL
UT WOS:000510871300003
PM 32051831
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Silveira, BKS
   Oliveira, TMS
   Andrade, PA
   Hermsdorff, HHM
   Rosa, CDB
   Franceschini, SDC
AF Souza Silveira, Brenda Kelly
   Silva Oliveira, Thatianne Moreira
   Andrade, Patricia Amaro
   Miranda Hermsdorff, Helen Hermana
   Barbosa Rosa, Carla de Oliveira
   Castro Franceschini, Sylvia do Carmo
TI Dietary Pattern and Macronutrients Profile on the Variation of
   Inflammatory Biomarkers: Scientific Update
SO CARDIOLOGY RESEARCH AND PRACTICE
LA English
DT Review
ID C-REACTIVE PROTEIN; HEALTHY EATING INDEX; CARDIOVASCULAR RISK-FACTORS;
   INDUCED WEIGHT-LOSS; MIDDLE-AGED MEN; METABOLIC SYNDROME; SYSTEMIC
   INFLAMMATION; MEDITERRANEAN DIET; OXIDATIVE STRESS; FATTY-ACIDS
AB It is known that the dietary pattern and macronutrients profile may influence the expression and secretion of inflammatory biomarkers, and the low-grade inflammation is associated with the manifestation of noncommunicable chronic diseases. Therefore, this review aimed to present and discuss the role of dietary patterns and macronutrients on the variation of inflammatory markers related to NCD risk. Scientific evidences within the last five years based on clinical trials, case-controls, cohorts, and cross-sectional studies indicate that normocaloric, carbohydrate-moderated, low-glycemic index, protein-moderated, monounsaturated and polyunsaturated fatty acid-rich, omega-3, and low-saturated fat diets display positive effects on the inflammatory state, both in healthy individuals and in those with cardiovascular risk, although the second group seems to benefit more from changes in the dietary profile.
C1 [Souza Silveira, Brenda Kelly; Silva Oliveira, Thatianne Moreira; Andrade, Patricia Amaro; Miranda Hermsdorff, Helen Hermana; Barbosa Rosa, Carla de Oliveira; Castro Franceschini, Sylvia do Carmo] Univ Fed Vicosa, Dept Nutr & Hlth, Vicosa, MG, Brazil.
C3 Universidade Federal de Vicosa
RP Franceschini, SDC (corresponding author), Univ Fed Vicosa, Dept Nutr & Hlth, Vicosa, MG, Brazil.
EM sylvia@ufv.br
FU Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES);
   FAPEMIG (State of Minas Gerais, Brazil); CNPq
FX The authors are grateful to Coordenacao de Aperfeicoamento de Pessoal de
   Nivel Superior (CAPES) for the grants conceded to Brenda Kelly Souza
   Silveira, Thatianne Moreira Silva Oliveira, and Patricia Amaro Andrade.
   This review is supported by the FAPEMIG (State of Minas Gerais, Brazil)
   and CNPq, related to research team's projects. HHM Hermsdorff and SDCC
   Franceschini are CNPq fellows.
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NR 107
TC 37
Z9 39
U1 0
U2 7
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2090-8016
EI 2090-0597
J9 CARDIOL RES PRACT
JI Cardiol. Res. Pract.
PY 2018
VL 2018
AR 4762575
DI 10.1155/2018/4762575
PG 18
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA GA6NW
UT WOS:000428450800001
PM 29725543
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Kong, LB
   Lu, Y
   Zhang, SY
   Nan, YM
   Qiao, L
AF Kong, Lingbo
   Lu, Yu
   Zhang, Siyu
   Nan, Yuemin
   Qiao, Liang
TI Role of Nutrition, Gene Polymorphism, and Gut Microbiota in
   Non-alcoholic Fatty Liver Disease
SO DISCOVERY MEDICINE
LA English
DT Article
ID HEPATIC STELLATE CELLS; VITAMIN-D DEFICIENCY; SUPERFAMILY MEMBER 2;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; HISTOLOGICAL SEVERITY;
   TRANSCRIPTION FACTORS; FRUCTOSE CONSUMPTION; METABOLIC SYNDROME; COPPER
   DEFICIENCY
AB Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease in the world. The nutrients play important roles in the development and progression of NAFLD. High-calorie diet, especially the diet rich in saturated fatty acids and cholesterol, as well as sugary drinks with high fructose content, induces hepatic steatosis and triggers progression of steatohepatitis, fibrosis, and even hepatocellular carcinoma. Disordered micronutrient status and gut microbiota are also involved in the pathogenesis of NAFLD. Nutrients related NAFLD could be aggravated by a genetic predisposition, for instance, genetic mutations in patatinlike phospholipase domain-containing 3 (PNPLA3) and transmembrane 6 superfamily member 2 (TM6SF2). Reduction of caloric intake through lifestyle interventions and use of dietary supplements such as omega-3 fatty acids, vitamins, and probiotics may help alleviate liver injury in NAFLD.
C1 [Kong, Lingbo; Lu, Yu; Zhang, Siyu; Nan, Yuemin] Hebei Med Univ, Hosp 3, Dept Tradit & Western Med Hepatol, Shijiazhuang 050051, Hebei, Peoples R China.
   [Qiao, Liang] Univ Sydney, Westmead Hosp, Westmead Millennium Inst Med Res, Storr Liver Ctr, Westmead, NSW 2145, Australia.
C3 Hebei Medical University; NSW Health; Westmead Hospital; University of
   Sydney
RP Nan, YM (corresponding author), Hebei Med Univ, Hosp 3, Dept Tradit & Western Med Hepatol, Shijiazhuang 050051, Hebei, Peoples R China.; Qiao, L (corresponding author), Univ Sydney, Westmead Hosp, Westmead Millennium Inst Med Res, Storr Liver Ctr, Westmead, NSW 2145, Australia.
EM nanyuemin@163.com; liang.qiao@sydney.edu.au
RI Kong, Lingbo/E-1209-2013; Wang, Yiru/JMB-2281-2023
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NR 140
TC 17
Z9 18
U1 1
U2 13
PU DISCOVERY MEDICINE
PI TIMONIUM
PA 10 GERARD AVE, STE 201, TIMONIUM, MD 21093 USA
SN 1539-6509
EI 1944-7930
J9 DISCOV MED
JI Discov. Med.
PD SEP
PY 2017
VL 24
IS 131
BP 95
EP 106
PG 12
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA FI5WR
UT WOS:000412058200003
PM 28972878
DA 2025-06-11
ER

PT J
AU Shin, JH
   Jung, JH
AF Shin, Jung Hee
   Jung, Ji Hye
TI Non-alcoholic fatty liver disease and flavonoids: Current perspectives
SO CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY
LA English
DT Review
ID KAPPA-B ACTIVATION; OXIDATIVE STRESS; CHOLESTEROL ACCUMULATION; HEPATIC
   CHOLESTEROL; INSULIN SENSITIVITY; ANTIOXIDANT STATUS; LIPID-METABOLISM;
   SOY ISOFLAVONES; GENE-EXPRESSION; OBESE
AB Non-alcoholic fatty liver disease (NAFLD) is an accumulation of fat in the liver despite a low level of alcohol intake, with signs of hepatomegaly. Although in the past, NAFLD was predominantly viewed as an aspect of metabolic syndrome, it is now considered that it should be classified as an independent condition similar to obesity, diabetes, and hypertension. Therefore, new treatment strategies, not based on correcting insulin resistance, are needed for NAFLD. This work analyzes methods of prevention, therapeutic approaches, and mechanisms involved in NAFLD, focusing on the use of flavonoids (epigallocatechin-3-gallate, resveratrol, anthocyanins, and isoflavones) with high antioxidant capacity. In addition, the mechanisms of cholesterol accumulation in the liver are identified as potential avenues for entirely new approaches to NAFLD treatment, contrasting the well-known relation between neutral fat and NAFLD. (C) 2016 Elsevier Masson SAS. All rights reserved.
C1 [Shin, Jung Hee] Joongbu Univ, Dept Food & Nutr, 201 Daehak Ro, Geumsan Gun, Chungcheongnam, South Korea.
   [Jung, Ji Hye] Inje Univ, Inst Clin Nutr, Mareunnae Ro 9, Seoul, South Korea.
C3 Joongbu University; Inje University
RP Jung, JH (corresponding author), Inje Univ, Inst Clin Nutr, Mareunnae Ro 9, Seoul, South Korea.
EM jhsn20@hanmail.net; jungjh@sookmyung.ac.kr
FU Joongbu University Research & Development Fund
FX The paper was supported by Joongbu University Research & Development
   Fund, in 2016.
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NR 63
TC 21
Z9 24
U1 1
U2 29
PU ELSEVIER MASSON, CORPORATION OFFICE
PI PARIS
PA 65 CAMILLE DESMOULINS CS50083 ISSY-LES-MOULINEAUX, 92442 PARIS, FRANCE
SN 2210-7401
EI 2210-741X
J9 CLIN RES HEPATOL GAS
JI Clin. Res. Hepatol. Gastroenterol.
PD FEB
PY 2017
VL 41
IS 1
BP 17
EP 24
DI 10.1016/j.clinre.2016.07.001
PG 8
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA EO9IO
UT WOS:000397002600008
PM 27545758
DA 2025-06-11
ER

PT J
AU Boucher, J
   Kleinridders, A
   Kahn, CR
AF Boucher, Jeremie
   Kleinridders, Andre
   Kahn, C. Ronald
TI Insulin Receptor Signaling in Normal and Insulin-Resistant States
SO COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY
LA English
DT Article
ID ENDOPLASMIC-RETICULUM STRESS; NECROSIS-FACTOR-ALPHA; SUBSTRATE-1
   TYROSINE PHOSPHORYLATION; REGULATORY SUBUNIT P85-ALPHA; FOXO
   TRANSCRIPTION FACTORS; TYPE-2 DIABETES-MELLITUS; SKELETAL-MUSCLE CELLS;
   HUMAN FAT-CELLS; NF-KAPPA-B; PROTEIN-KINASE
AB In the wake of the worldwide increase in type-2 diabetes, a major focus of research is understanding the signaling pathways impacting this disease. Insulin signaling regulates glucose, lipid, and energy homeostasis, predominantly via action on liver, skeletal muscle, and adipose tissue. Precise modulation of this pathway is vital for adaption as the individual moves from the fed to the fasted state. The positive and negative modulators acting on different steps of the signaling pathway, as well as the diversity of protein isoform interaction, ensure a proper and coordinated biological response to insulin in different tissues. Whereas genetic mutations are causes of rare and severe insulin resistance, obesity can lead to insulin resistance through a variety of mechanisms. Understanding these pathways is essential for development of new drugs to treat diabetes, metabolic syndrome, and their complications.
C1 [Boucher, Jeremie; Kleinridders, Andre; Kahn, C. Ronald] Brigham & Womens Hosp, Joslin Diabet Ctr, Sect Integrat Physiol & Metab, Boston, MA 02115 USA.
   [Boucher, Jeremie; Kleinridders, Andre; Kahn, C. Ronald] Brigham & Womens Hosp, Dept Med, Boston, MA 02115 USA.
   [Boucher, Jeremie; Kleinridders, Andre; Kahn, C. Ronald] Harvard Univ, Sch Med, Boston, MA 02115 USA.
C3 Harvard University; Harvard University Medical Affiliates; Brigham &
   Women's Hospital; Joslin Diabetes Center, Inc.; Harvard University;
   Harvard University Medical Affiliates; Brigham & Women's Hospital;
   Harvard University; Harvard Medical School
RP Kahn, CR (corresponding author), Brigham & Womens Hosp, Joslin Diabet Ctr, Sect Integrat Physiol & Metab, 75 Francis St, Boston, MA 02115 USA.
EM c.ronald.kahn@joslin.harvard.edu
RI Boucher, Jeremie/G-6602-2015; Kahn, Ronald/AAY-2435-2021
OI Kleinridders, Andre/0000-0002-4248-6366
FU NIDDK NIH HHS [R01 DK055545, P30 DK036836, R01 DK033201, R37 DK031036]
   Funding Source: Medline
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NR 246
TC 991
Z9 1183
U1 8
U2 159
PU COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
PI COLD SPRING HARBOR
PA 1 BUNGTOWN RD, COLD SPRING HARBOR, NY 11724 USA
SN 1943-0264
J9 CSH PERSPECT BIOL
JI Cold Spring Harbor Perspect. Biol.
PD JAN
PY 2014
VL 6
IS 1
AR a009191
DI 10.1101/cshperspect.a009191
PG 23
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA 282ZO
UT WOS:000329214100002
PM 24384568
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Ross, JS
   Russo, SB
   Chavis, GC
   Cowart, LA
AF Ross, Jessica S.
   Russo, Sarah B.
   Chavis, Georgia C.
   Cowart, Lauren A.
TI Sphingolipid regulators of cellular dysfunction in Type 2 diabetes
   mellitus: a systems overview
SO CLINICAL LIPIDOLOGY
LA English
DT Review
DE free fatty acids; lipotoxicity; obesity; sphingolipid; Type 2 diabetes
   mellitus
ID NECROSIS-FACTOR-ALPHA; FREE FATTY-ACIDS; INDUCED INSULIN-RESISTANCE;
   ACTIVATED RECEPTOR-ALPHA; LOW-DENSITY-LIPOPROTEIN; PANCREATIC
   BETA-CELLS; ISCHEMIC/REPERFUSED RAT-HEART; ENDOPLASMIC-RETICULUM STRESS;
   INDUCED CARDIAC-HYPERTROPHY; CORONARY-ARTERY-DISEASE
AB Climbing obesity rates have contributed to worldwide increases in obesity-associated diseases, including the metabolic syndrome and Type 2 diabetes mellitus (T2DM). Sphingolipids, an important class of structural and signaling lipids, have emerged as key players in the development and pathogenesis of insulin resistance and T2DM. More specifically, sphingolipids have been demonstrated to play integral roles in lipotoxicity and other aspects of pathogenesis in T2DM, although the cellular mechanisms by which this occurs and by which sphingolipid metabolism is dysregulated in T2DM remain under investigation. This review summarizes current knowledge of sphingolipid metabolism and signaling in key organs and tissues affected by T2DM, including the pancreas, adipose tissue, skeletal muscle, cardiovascular system and liver, and highlights areas that ripe for future investigation.
C1 [Ross, Jessica S.; Russo, Sarah B.; Chavis, Georgia C.; Cowart, Lauren A.] Med Univ S Carolina, Dept Biochem & Mol Biol, Charleston, SC 29425 USA.
   [Cowart, Lauren A.] Ralph H Johnson Vet Affairs Med Ctr, Charleston, SC 29401 USA.
C3 Medical University of South Carolina; US Department of Veterans Affairs;
   Veterans Health Administration (VHA); Ralph H Johnson VA Medical Center
RP Cowart, LA (corresponding author), Med Univ S Carolina, Dept Biochem & Mol Biol, Charleston, SC 29425 USA.
EM cowartl@musc.edu
RI Cowart, Lauren/KUC-8358-2024; Cowart, Lauren/F-2375-2017
OI Cowart, Lauren/0000-0002-5312-5232
FU NIH [1RO1HL117233, 5P30 GM103339-03]; Veteran's Affairs Merit Award [210
   IBX000200-04A2, T32 HL007260-38]
FX This work was supported in part by NIH Grants 1RO1HL117233 and 5P30
   GM103339-03, Veteran's Affairs Merit Award 210 IBX000200-04A2, all to LA
   Cowart, and T32 HL007260-38, to SB Russo. The authors have no other
   relevant affiliations or financial involvement with any organization or
   entity with a financial interest in or financial conflict with the
   subject matter or materials discussed in the manuscript apart from those
   disclosed.
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NR 188
TC 12
Z9 13
U1 0
U2 19
PU FUTURE MEDICINE LTD
PI LONDON
PA UNITEC HOUSE, 3RD FLOOR, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON, N3
   1QB, ENGLAND
SN 1758-4299
EI 1758-4302
J9 CLIN LIPIDOL
JI Clin. Lipidol.
PY 2014
VL 9
IS 5
BP 553
EP 569
DI 10.2217/CLP.14.37
PG 17
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA AU5LB
UT WOS:000345647300009
PM 29643939
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Cai, DS
AF Cai, Dongsheng
TI Neuroinflammation and neurodegeneration in overnutrition-induced
   diseases
SO TRENDS IN ENDOCRINOLOGY AND METABOLISM
LA English
DT Review
DE inflammation; neurodegeneration; neural stem cells; hypothalamus; brain;
   NF-kappa B; obesity; diabetes
ID HIGH-FAT DIET; NF-KAPPA-B; OXIDATIVE STRESS; INSULIN-RESISTANCE; LEPTIN
   RESISTANCE; HYPOTHALAMIC INFLAMMATION; COGNITIVE IMPAIRMENT; ADULT
   NEUROGENESIS; METABOLIC SYNDROME; ENERGY-BALANCE
AB Overnutrition-induced diseases such as obesity and type 2 diabetes (T2D) involve neural dysregulation of metabolic physiology. Recently, interdisciplinary research in neuroscience and immunology has linked overnutrition to a non-classical onset of inflammation in the brain, particularly in the hypothalamus. This neuroinflammation impairs central regulatory pathways of energy balance and nutrient metabolism, and leads to obesity, diabetes, and cardiovascular complications. This review describes recent findings on the roles of overnutrition-induced hypothalamic inflammation in neurodegeneration and defective adult neurogenesis, as well as in impaired neural stem cell regeneration, and their relevance to obesity and related diseases. In addition, commonalities in terms of neuroinflammation between neurodegenerative diseases and overnutrition-induced metabolic diseases are discussed. Targeting neuroinflammation and neurodegeneration will provide promising approaches for treating obesity and other overnutrition-related diseases.
C1 Albert Einstein Coll Med, Diabet Res Ctr, Inst Aging, Dept Mol Pharmacol, Bronx, NY 10461 USA.
C3 Montefiore Medical Center; Albert Einstein College of Medicine; Yeshiva
   University
RP Cai, DS (corresponding author), Albert Einstein Coll Med, Diabet Res Ctr, Inst Aging, Dept Mol Pharmacol, Bronx, NY 10461 USA.
EM dongsheng.cai@einstein.yu.edu
RI Cai, Dongsheng/CAH-8271-2022
FU National Institutes of Health [R01 DK078750, R01 AG031774]; American
   Diabetes Association Basic Research Award [1-12-BS-20]
FX The author sincerely thanks Cai laboratory members for their research
   relevant to this review; our work in this field has been supported by
   National Institutes of Health grants (R01 DK078750 and R01 AG031774 to
   D.C.) and the American Diabetes Association Basic Research Award
   (#1-12-BS-20 to D.C.). D.C. is an Irma T. Hirschl Scholar.
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NR 108
TC 199
Z9 224
U1 1
U2 54
PU ELSEVIER SCIENCE LONDON
PI LONDON
PA 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND
SN 1043-2760
EI 1879-3061
J9 TRENDS ENDOCRIN MET
JI Trends Endocrinol. Metab.
PD JAN
PY 2013
VL 24
IS 1
BP 40
EP 47
DI 10.1016/j.tem.2012.11.003
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 077FY
UT WOS:000314014500006
PM 23265946
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT S
AU Odegaard, JI
   Chawla, A
AF Odegaard, Justin I.
   Chawla, Ajay
BE Abbas, AK
   Galli, SJ
   Howley, PM
TI Alternative Macrophage Activation and Metabolism
SO ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 6
SE Annual Review of Pathology-Mechanisms of Disease
LA English
DT Review; Book Chapter
DE obesity; insulin resistance; inflammation; diabetes; PPAR
ID ENDOPLASMIC-RETICULUM STRESS; INSULIN-RECEPTOR SUBSTRATE-1;
   ADIPOSE-TISSUE INFLAMMATION; FACTOR-ALPHA BLOCKADE; REGULATORY T-CELLS;
   PPAR-DELTA; INNATE IMMUNITY; KUPFFER CELLS; FATTY-ACIDS; TARGETED
   DISRUPTION
AB Obesity and its attendant metabolic disorders represent the great public health challenge of our time. Recent evidence suggests that onset of inflammation in metabolic tissues pathogenically links obesity to insulin resistance and type 2 diabetes. In this review, we briefly summarize the extant literature, paying special attention to the central role of the tissue-associated macrophage in the initiation of metabolic inflammation. We argue that rather than representing simple inflammatory disease, obesity and metabolic syndrome represent derangements in macrophage activation with concomitant loss of metabolic coordination. As such, the sequelae of obesity are as much products of the loss of positive macrophage influences as they are of the presence of deleterious inflammation. The therapeutic implications of this conclusion are profound because they suggest that pharmacologic targeting of macrophage activation, rather than simply inflammation, might be efficacious in treating this global epidemic.
C1 [Odegaard, Justin I.] Stanford Univ, Sch Med, Dept Pathol, Stanford, CA 94305 USA.
   [Chawla, Ajay] Stanford Univ, Sch Med, Div Endocrinol Metab & Gerontol, Stanford, CA 94305 USA.
   [Chawla, Ajay] Stanford Univ, Sch Med, Dept Med, Grad Program Immunol, Stanford, CA 94305 USA.
C3 Stanford University; Stanford University; Stanford University
RP Odegaard, JI (corresponding author), Stanford Univ, Sch Med, Dept Pathol, Stanford, CA 94305 USA.
EM odegaard@stanford.edu; achawla@stanford.edu
FU NHLBI NIH HHS [R01 HL076746, HL076746] Funding Source: Medline; NIDDK
   NIH HHS [DK081405, R01 DK081405, DK076760, R01 DK076760] Funding Source:
   Medline; NIH HHS [1DP1OD006415, DP1 OD006415] Funding Source: Medline
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NR 129
TC 500
Z9 581
U1 1
U2 80
PU ANNUAL REVIEWS
PI PALO ALTO
PA 4139 EL CAMINO WAY, PO BOX 10139, PALO ALTO, CA 94303-0897 USA
SN 1553-4006
BN 978-0-8243-4306-4
J9 ANNU REV PATHOL-MECH
JI Annu. Rev. Pathol.-Mech Dis.
PY 2011
VL 6
BP 275
EP 297
DI 10.1146/annurev-pathol-011110-130138
PG 23
WC Pathology
WE Book Citation Index – Science (BKCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Pathology
GA BUD40
UT WOS:000288922800012
PM 21034223
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Falkai, P
   Schmitt, A
   Rosenbeiger, CP
   Maurus, I
   Hattenkofer, L
   Hasan, A
   Malchow, B
   Heim-Ohmayer, P
   Halle, M
   Heitkamp, M
AF Falkai, Peter
   Schmitt, Andrea
   Rosenbeiger, Christian P.
   Maurus, Isabel
   Hattenkofer, Lisa
   Hasan, Alkomiet
   Malchow, Berend
   Heim-Ohmayer, Pascale
   Halle, Martin
   Heitkamp, Melanie
TI Aerobic exercise in severe mental illness: requirements from the
   perspective of sports medicine
SO EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
LA English
DT Review
DE Major depression; Bipolar disorder; Schizophrenia; Aerobic exercise;
   Physical activity; Cardiorespiratory fitness; Neuroplasticity
ID MAJOR DEPRESSIVE DISORDER; RANDOMIZED CONTROLLED-TRIAL; QUALITY-OF-LIFE;
   PHYSICAL-ACTIVITY; METABOLIC SYNDROME; HIPPOCAMPAL VOLUME;
   CARDIORESPIRATORY FITNESS; COGNITIVE REMEDIATION; CHRONIC-SCHIZOPHRENIA;
   PSYCHOTIC DISORDERS
AB Major depression, bipolar disorder, and schizophrenia are severe mental illnesses. Despite receiving psychopharmacological and psychosocial treatments, about half of patients develop a chronic course with residual cognitive and negative symptoms and have a high risk for cardiovascular disease and reduced life expectancy. Therefore, add-on innovative treatment approaches are needed to improve outcome. Aerobic exercise interventions have been shown to improve global functioning, cognition, and negative and depressive symptoms in these patients. The basic mechanism of these exercise-related changes has been reported to be improved brain plasticity, e.g., increased volume of disease-related brain regions such as the hippocampus. The optimal type, duration, and frequency of exercise have not yet been determined and need to be addressed in supervised physical exercise studies. Because of the low physical activity levels, lack of drive related to negative and depressive symptoms, and high prevalence of cardiovascular comorbidities in patients with severe mental illness, besides aiming to improve symptoms of mental illness, exercise interventions should also aim to increase cardiorespiratory fitness, which they should comprehensively assess by direct measurements of maximal oxygen uptake. Based on the recommendations for developing cardiorespiratory fitness by the American College of Sports Medicine, 150 min moderate-intensity training per week or vigorous-intensity exercise training for 75 min per week are appropriate. Most studies have had relatively short intervention periods, so future studies should focus on long-term adherence to exercise by implementing motivational strategies supported by telemedicine and by identifying and targeting typical barriers to exercise in this patient population.
C1 [Falkai, Peter; Schmitt, Andrea; Rosenbeiger, Christian P.; Maurus, Isabel; Hattenkofer, Lisa] Univ Hosp, LMU Munich, Dept Psychiat & Psychotherapy, Nussbaumstr 7, D-80336 Munich, Germany.
   [Schmitt, Andrea] Univ Sao Paulo, Inst Psychiat, Lab Neurosci LIM27, Sao Paulo, Brazil.
   [Hasan, Alkomiet] Univ Augsburg, Fac Med, Dept Psychiat & Psychosomat Univ Augsburg, Bezirkskrankenhaus Augsburg, Augsburg, Germany.
   [Malchow, Berend] Univ Med Ctr Gottingen, Dept Psychiat & Psychotherapy, Von Siebold Str 5, D-37075 Gottingen, Germany.
   [Heim-Ohmayer, Pascale; Halle, Martin; Heitkamp, Melanie] Tech Univ Munich, Univ Hosp, Med Fac, Dept Prevent & Sports Med,Klinikum Rechts Isar, Munich, Germany.
   [Halle, Martin] DZHK German Ctr Cardiovasc Res, Partner Site Munich Heart Alliance, Munich, Germany.
C3 University of Munich; Universidade de Sao Paulo; University of Augsburg;
   University of Gottingen; UNIVERSITY GOTTINGEN HOSPITAL; University of
   Munich; Technical University of Munich; Munich Heart Alliance; German
   Centre for Cardiovascular Research
RP Maurus, I (corresponding author), Univ Hosp, LMU Munich, Dept Psychiat & Psychotherapy, Nussbaumstr 7, D-80336 Munich, Germany.
EM isabel.maurus@med.uni-muenchen.de
RI Maurus, Isabel/HMO-5534-2023; Heitkamp, Melanie/AGP-4644-2022; Malchow,
   Berend/AAM-9172-2020; Falkai, Peter/E-3273-2017
OI Maurus, Isabel/0000-0002-6208-5180; Malchow, Berend/0000-0002-5707-7602;
   Heitkamp, Melanie/0000-0002-1544-6764
FU grant Klinische Forschergruppe (KFO) 241 from the Deutsche
   Forschungsgemeinschaft (DFG); grant PsyCourse from the Deutsche
   Forschungsgemeinschaft (DFG) [FA241/16-1]; German Federal Ministry of
   Education and Research (BMBF) [01EE1407E]
FX This research was funded by the grants Klinische Forschergruppe (KFO)
   241 and PsyCourse (FA241/16-1) to P. Falkai from the Deutsche
   Forschungsgemeinschaft (DFG). Further funding was received from the
   German Federal Ministry of Education and Research (BMBF) through the
   research network on psychiatric diseases ESPRIT (grant number 01EE1407E)
   to P. Falkai, A. Hasan, A. Schmitt. The authors thank Jacquie Klesing,
   BMedSci (Hons), Board-certified Editor in the Life Sciences (ELS), for
   editing assistance with the manuscript; Ms. Klesing received
   compensation for her work from the LMU Munich, Germany.
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NR 120
TC 20
Z9 21
U1 3
U2 41
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0940-1334
EI 1433-8491
J9 EUR ARCH PSY CLIN N
JI Eur. Arch. Psych. Clin. Neurosci.
PD JUN
PY 2022
VL 272
IS 4
BP 643
EP 677
DI 10.1007/s00406-021-01360-x
EA DEC 2021
PG 35
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Psychiatry
GA 1D5PQ
UT WOS:000727169900001
PM 34873635
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Castelo-Branco, A
   Chiesa, F
   Bengtsson, CE
   Lee, S
   Minton, NN
   Niemcryk, S
   Lindholm, A
   Rosenlund, M
   Piehl, F
   Montgomery, S
AF Castelo-Branco, Anna
   Chiesa, Flaminia
   Bengtsson, Camilla E.
   Lee, Sally
   Minton, Neil N.
   Niemcryk, Steve
   Lindholm, Anders
   Rosenlund, Mats
   Piehl, Fredrik
   Montgomery, Scott
TI Non-infectious comorbidity in patients with multiple sclerosis: A
   national cohort study in Sweden
SO MULTIPLE SCLEROSIS JOURNAL-EXPERIMENTAL TRANSLATIONAL AND CLINICAL
LA English
DT Article
DE Multiple sclerosis; comorbidity; cardiovascular diseases; depression;
   cohort study; incidence
ID CARDIOVASCULAR-DISEASES; RISK-FACTORS; METABOLIC SYNDROME; PREVALENCE;
   INCREASES; STROKE; MS
AB Background: Comorbidity is of significant concern in multiple sclerosis (MS). Few population-based studies have reported conditions occurring in MS after diagnosis, especially in contemporary cohorts.
   Objective: To explore incident comorbidity, mortality and hospitalizations in MS, stratified by age and sex.
   Methods: In a Swedish population-based cohort study 6602 incident MS patients (aged >= 18 years) and 61,828 matched MS-free individuals were identified between 1 January 2008 and 31 December 2016, using national registers. Incidence rates (IRs) and incidence rate ratios (IRRs) with 95% CI were calculated for each outcome.
   Results: IRs of cardiovascular disease (CVD) were higher among MS patients than MS-free individuals, (major adverse CVD: IRR 1.42; 95% CI 1.12-1.82; hemorrhagic/ischemic stroke: 1.46; 1.05-2.02; transient ischemic attack: 1.65; 1.09-2.50; heart failure: 1.55; 1.15-2.10); venous thromboembolism: 1.42; 1.14-1.77). MS patients also had higher risks of several non-CVDs such as autoimmune conditions (IRR 3.83; 3.01-4.87), bowel dysfunction (2.16; 1.86-2.50), depression (2.38; 2.11-2.68), and fractures (1.32; 1.19-1.47), as well as being hospitalized and to suffer from CVD-related deaths ((1.91; 1.00-3.65), particularly in females (3.57; 1.58-8.06)).
   Conclusion: MS-patients experience a notable comorbidity burden which emphasizes the need for integrated disease management in order to improve patient care and long-term outcomes of MS.
C1 [Castelo-Branco, Anna; Chiesa, Flaminia; Bengtsson, Camilla E.] IQVIA Nord, Real World Insights, Pyramidvagen 7, S-16956 Solna, Sweden.
   [Lee, Sally; Minton, Neil N.; Niemcryk, Steve; Lindholm, Anders] Celgene Corp, Summit, NJ USA.
   [Rosenlund, Mats] Karolinska Inst, Dept Learning Informat Management & Eth, Stockholm, Sweden.
   [Piehl, Fredrik] Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden.
   [Montgomery, Scott] Orebro Univ Hosp, Sch Med Sci, Clin Epidemiol & Biostat, Orebro, Sweden.
   [Montgomery, Scott] Orebro Univ, Orebro, Sweden.
   [Montgomery, Scott] Karolinska Inst, Div Clin Epidemiol, Stockholm, Sweden.
   [Montgomery, Scott] UCL, Dept Epidemiol & Publ Hlth, London, England.
C3 Bristol-Myers Squibb; Celgene Corporation; Karolinska Institutet;
   Karolinska Institutet; Orebro University; Orebro University; Karolinska
   Institutet; University of London; University College London
RP Bengtsson, CE (corresponding author), IQVIA Nord, Real World Insights, Pyramidvagen 7, S-16956 Solna, Sweden.
EM cbengtsson@iqvia.com
RI Bengtsson, Camilla/A-8475-2015; Piehl, Fredrik/E-3451-2013; Montgomery,
   Scott/GLU-3491-2022
OI Piehl, Fredrik/0000-0001-8329-5219; Montgomery,
   Scott/0000-0001-6328-5494
FU IQVIA
FX The author(s) disclosed receipt of the following financialsupport for
   the research, authorship, and/or publicationofthis article: IQVIA was
   commissioned, and financed, to conduct the study on behalf of Celgene.
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NR 35
TC 14
Z9 14
U1 0
U2 2
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
EI 2055-2173
J9 MULT SCLER J-EXP TRA
JI Mult. Scler. J. Exp. Transl. Clin.
PD JUL-SEP
PY 2020
VL 6
IS 3
DI 10.1177/2055217320947761
PG 10
WC Clinical Neurology
WE Emerging Sources Citation Index (ESCI)
SC Neurosciences & Neurology
GA TR7BE
UT WOS:000679115300010
PM 32864156
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Jeong, H
   Baek, SY
   Kim, SW
   Eun, YH
   Kim, IY
   Kim, H
   Lee, J
   Koh, EM
   Cha, HS
AF Jeong, Hyemin
   Baek, Sun Young
   Kim, Seon Woo
   Eun, Yeong Hee
   Kim, In Young
   Kim, Hyungjin
   Lee, Jaejoon
   Koh, Eun-Mi
   Cha, Hoon-Suk
TI Comorbidities of rheumatoid arthritis: Results from the Korean National
   Health and Nutrition Examination Survey
SO PLOS ONE
LA English
DT Article
ID HLA-DRB1 SHARED EPITOPE; SINGLE-NUCLEOTIDE POLYMORPHISM; CARDIOVASCULAR
   RISK-FACTORS; METABOLIC SYNDROME; MYOCARDIAL-INFARCTION;
   DIABETES-MELLITUS; ADULT PATIENTS; HEPATITIS-B; DISEASE; PREVALENCE
AB This study aimed to evaluate the prevalence of comorbidities in patients with rheumatoid arthritis (RA) compared with the non-RA population. The 2010-2012 Korea National Health and Nutrition Examination Survey (KNHANES), which assesses the general health status of populations in South Korea using interviews and basic health assessment, was analyzed retrospectively. Weighted prevalence and odds ratio (OR) of comorbidities were analyzed in patients with RA compared with the non-RA population. The overall weighted (n = 37,453,158) prevalence of RA was 1.5%. Patients with RA were older and more female predominant than subjects without RA. The prevalence of living in an urban area, college graduation, alcohol consumption and smoking was lower in patients with RA than non-RA. Patients with RA had more comorbidities including hypertension, dyslipidemia, myocardial infarction (MI) or angina, stoke, osteoarthritis, lung cancer, colon cancer, pulmonary tuberculosis, asthma, diabetes, depression, thyroid disease and chronic kidney disease. After adjusting socioeconomic and lifestyle characteristics, RA was associated with an increased prevalence of MI or angina (OR 1.86, 95% CI 1.17-2.96, p = 0.009), pulmonary TB (OR 1.95, 95% CI 1.24-3.09, p = 0.004), asthma (OR 1.97, 95% CI 1.05-3.71, p = 0.036), thyroid disease (OR 1.71, 95% CI 1.05-2.77), depression (OR 2.38, 95% CI 1.47-3.85, p < 0.001) and hepatitis B (OR 2.34, 95% CI 1.15-4.80, p = 0.020) compared with the non-RA population. Prevalence of solid cancer was not significantly associated with RA after adjustment.
C1 [Jeong, Hyemin; Eun, Yeong Hee; Kim, In Young; Kim, Hyungjin; Lee, Jaejoon; Koh, Eun-Mi; Cha, Hoon-Suk] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Med, Seoul, South Korea.
   [Baek, Sun Young; Kim, Seon Woo] Samsung Med Ctr, Biostat & Clin Epidemiol Ctr, Seoul, South Korea.
C3 Sungkyunkwan University (SKKU); Samsung Medical Center; Sungkyunkwan
   University (SKKU); Samsung Medical Center
RP Cha, HS (corresponding author), Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Med, Seoul, South Korea.
EM hoonsuk.cha@samsung.com
RI Kim, Hyungjin/JED-7172-2023; kim, seonwoo/IWE-3812-2023
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NR 80
TC 44
Z9 46
U1 0
U2 9
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD APR 19
PY 2017
VL 12
IS 4
AR e0176260
DI 10.1371/journal.pone.0176260
PG 15
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA ES9KK
UT WOS:000399875600099
PM 28423031
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Burek-Michalska, A
   Turno-Krecicka, A
   Grant-Kels, JM
   Grzybowski, A
AF Burek-Michalska, Alicja
   Turno-Krecicka, Anna
   Grant-Kels, Jane M.
   Grzybowski, Andrzej
TI Biologic therapies for psoriasis and eyes
SO CLINICS IN DERMATOLOGY
LA English
DT Article
DE cases. Streptococcal infection; stress; smoking; obesity; alco
ID REFRACTORY UVEITIS; OPTIC NEURITIS; ETANERCEPT; ADALIMUMAB; EXPERIENCE;
   REGISTRY; SAFETY
AB Psoriasis is a systemic inflammatory disorder, manifested mainly by skin lesions, but the inflammation also may affect the joints and eye. Many comorbidities have been described in association with psoriasis, including metabolic syndrome and coronary plaques. The pathomechanism of psoriasis is multifaceted. Both genetic and immunologic aspects play a role in stimulating inflammation. Genetic susceptibility is conditioned by presence of the human leukocyte antigen-C *06:02 risk allele and the inflammatory reaction secondary to cytokines, such as tumor necrosis factor alpha, interleukin 17 (IL-17), IL-20, IL-23, and interferon alfa. Besides the conventional therapy of topical steroids and immunosuppressants, biologic therapies are widely used in the treatment of psoriasis, psoriatic arthritis, and coexisting uveitis. In the majority of cases, biologic therapy has a beneficial effect on uveitis, but in some cases, some of these drugs can lead to serious side effects threatening vision.(c) 2023 Elsevier Inc. All rights reserved.
C1 [Burek-Michalska, Alicja; Turno-Krecicka, Anna] Wroclaw Med Univ, Dept Ophthalmol, Wroclaw, Poland.
   [Turno-Krecicka, Anna] Univ Connecticut, Sch Med, Dept Dermatol, Farmington, CT USA.
   [Grant-Kels, Jane M.] Univ Florida, Coll Med, Dept Dermatol, Gainesville, FL USA.
   [Grzybowski, Andrzej] Univ Warmia & Mazury, Dept Ophthalmol, Olsztyn, Poland.
   [Grzybowski, Andrzej] Inst Res Ophthalmol, Poznan, Poland.
C3 Wroclaw Medical University; University of Connecticut; State University
   System of Florida; University of Florida; University of Warmia & Mazury
RP Burek-Michalska, A (corresponding author), Wroclaw Med Univ, Dept Ophthalmol, Wroclaw, Poland.
EM alicja.burek@gmail.com
RI Grzybowski, A/E-4486-2010
OI Turno-Krecicka, Anna/0000-0001-6732-1851
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NR 38
TC 3
Z9 3
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0738-081X
EI 1879-1131
J9 CLIN DERMATOL
JI Clin. Dermatol.
PD JUL-AUG
PY 2023
VL 41
IS 4
BP 523
EP 527
DI 10.1016/j.clindermatol.2023.08.003
EA NOV 2023
PG 5
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA CC5W6
UT WOS:001123074500001
PM 37586569
DA 2025-06-11
ER

PT J
AU Ikeda, Y
   Funamoto, M
   Tsuchiya, K
AF Ikeda, Yasumasa
   Funamoto, Masafumi
   Tsuchiya, Koichiro
TI The role of iron in obesity and diabetes
SO JOURNAL OF MEDICAL INVESTIGATION
LA English
DT Review
DE iron; obesity; diabetes; macrophage
ID SERUM AMINOTRANSFERASE LEVELS; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   ADIPOSE-TISSUE; HEPATITIS-C; FERRITIN; RISK; MACROPHAGES; TRANSFERRIN;
   INFLAMMATION
AB Iron is an essential trace metal for all life, but excess iron causes oxidative stress through catalyzing the toxic hydroxy-radical production via the Fenton reaction. The number of patients with obesity and diabetes has been increasing worldwide, and their onset and development are affected by diet. In both clinical and experimental studies, a high body iron content was associated with obesity and diabetes, and the reduction of body iron content to an appropriate level can ameliorate the status and development of obesity and diabetes. Macrophages play an essential role in the pathophysiology of obesity and diabetes, and in the metabolism and homeostasis of iron in the body. Recent studies demonstrated that macrophage polarization is related to adipocyte hypertrophy and insulin resistance through their capabilities of iron handling. Control of iron in macrophages is a potential therapeutic strategy for obesity and diabetes.
C1 [Ikeda, Yasumasa; Funamoto, Masafumi] Univ Tokushima, Grad Sch, Inst Biomed Sci, Dept Pharmacol, 3-18-15 Kuramoto Cho, Tokushima 7708503, Japan.
   [Tsuchiya, Koichiro] Univ Tokushima, Grad Sch, Inst Biomed Sci, Dept Med Pharmacol, Tokushima, Japan.
C3 Tokushima University; Tokushima University
RP Ikeda, Y (corresponding author), Univ Tokushima, Grad Sch, Inst Biomed Sci, Dept Pharmacol, 3-18-15 Kuramoto Cho, Tokushima 7708503, Japan.
EM yasuike@tokushima-u.ac.jp
OI Ikeda, Yasumasa/0000-0003-4318-7349
FU Grants-in-Aid for Scientific Research [21K07914] Funding Source: KAKEN
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NR 90
TC 9
Z9 9
U1 0
U2 21
PU UNIV TOKUSHIMA SCH MEDICINE
PI TOKUSHIMA
PA 3-18-15, KURAMOTO-CHO, TOKUSHIMA, 00000, JAPAN
SN 1343-1420
EI 1349-6867
J9 J MED INVESTIG
JI J. Med. Investig.
PD FEB
PY 2022
VL 69
IS 1-2
BP 1
EP 7
PG 7
WC Medicine, Research & Experimental
WE Emerging Sources Citation Index (ESCI)
SC Research & Experimental Medicine
GA 2B9UO
UT WOS:000810526400001
PM 35466128
DA 2025-06-11
ER

PT J
AU Feng, G
   Byrne, CD
   Targher, G
   Wang, FD
   Zheng, MH
AF Feng, Gong
   Byrne, Christopher D.
   Targher, Giovanni
   Wang, Fudi
   Zheng, Ming-Hua
TI Ferroptosis and metabolic dysfunction-associated fatty liver disease: Is
   there a link?
SO LIVER INTERNATIONAL
LA English
DT Review
DE ferroptosis; MAFLD; metabolic syndrome; pathogenesis; type 2 diabetes
ID OXIDATIVE STRESS; IRON-METABOLISM; CELL-DEATH; ACTIVATION; FIBROSIS;
   OBESITY
AB Non-alcoholic fatty liver disease (NAFLD), recently re-defined and re-classified as metabolic dysfunction-associated fatty liver disease (MAFLD), has become increasingly prevalent and emerged as a public health problem worldwide. To date, the precise pathogenic mechanisms underpinning MAFLD are not entirely understood, and there is no effective pharmacological therapy for NAFLD/MAFLD. As a newly discovered form of iron-dependent programmed cell death, ferroptosis can be involved in the development and progression of various chronic diseases, but the pathogenic connections and mechanisms that link MAFLD and ferroptosis have not been fully elucidated. The main characteristics of ferroptosis are the accumulation of lipid peroxides and reactive oxygen species. In this brief narrative review, the mechanisms of ferroptosis and its putative pathogenic role in MAFLD are discussed to highlight potential new research directions and ideas for the prevention and treatment of MAFLD.
C1 [Feng, Gong] Xian Med Univ, Xian, Peoples R China.
   [Byrne, Christopher D.] Univ Hosp Southampton, Southampton Gen Hosp, Southampton Natl Inst Hlth Res Biomed Res Ctr, Southampton, Hants, England.
   [Targher, Giovanni] Univ Verona, Dept Med, Sect Endocrinol Diabet & Metab, Verona, Italy.
   [Targher, Giovanni] Azienda Osped Univ Integrata Verona, Verona, Italy.
   [Wang, Fudi] Zhejiang Univ, Affiliated Hosp 4, Sch Publ Hlth, Sch Med, Hangzhou, Peoples R China.
   [Wang, Fudi] Univ South China, Affiliated Hosp 1, Sch Publ Hlth, Hengyang Med Sch,Basic Med Sci, Hengyang, Peoples R China.
   [Zheng, Ming-Hua] Wenzhou Med Univ, Affiliated Hosp 1, Dept Hepatol, NAFLD Res Ctr, 2 Fuxue Lane, Wenzhou 325000, Peoples R China.
   [Zheng, Ming-Hua] Wenzhou Med Univ, Inst Hepatol, Wenzhou, Peoples R China.
   [Zheng, Ming-Hua] Key Lab Diag & Treatment Dev Chron Liver Dis Zhej, Wenzhou, Peoples R China.
C3 Xi'an Medical University; University of Southampton; University of
   Verona; University of Verona; Azienda Ospedaliera Universitaria
   Integrata Verona; Zhejiang University; University of South China;
   Wenzhou Medical University; Wenzhou Medical University
RP Zheng, MH (corresponding author), Wenzhou Med Univ, Affiliated Hosp 1, Dept Hepatol, NAFLD Res Ctr, 2 Fuxue Lane, Wenzhou 325000, Peoples R China.; Wang, FD (corresponding author), Zhejiang Univ, Sch Med, Affiliated Hosp 1, Sch Publ Hlth,Inst Translat Med, Hangzhou 310058, Peoples R China.
EM fwang@zju.edu.cn; zhengmh@wmu.edu.cn
RI Zheng, Ming-Hua/H-5584-2019; Targher, Giovanni/AAB-9008-2019; Wang,
   Fudi/L-7888-2018
OI Wang, Fudi/0000-0001-8730-0003; Feng, Gong/0000-0001-5394-0029; Zheng,
   Ming-Hua/0000-0003-4984-2631; Targher, Giovanni/0000-0002-4325-3900;
   Byrne, Christopher D/0000-0001-6322-7753
FU National Natural Science Foundation of China [82070588]; National Key
   Research and Development Program of China [2018YFA0507802]; High Level
   Creative Talents from Department of Public Health in Zhejiang Province
   [S2032102600032]; Science and Technology project of Shaanxi Province
   [2021ZDLSF02-09]; Project of New Century 551 Talent Nurturing in
   Wenzhou; University School of Medicine of Verona, Verona, Italy;
   Southampton NIHR Biomedical Research Centre, UK [IS-BRC-20004]
FX This work was supported by grants from the National Natural Science
   Foundation of China (82070588), National Key Research and Development
   Program of China (2018YFA0507802 to F.W.), High Level Creative Talents
   from Department of Public Health in Zhejiang Province (S2032102600032),
   Science and Technology project of Shaanxi Province (2021ZDLSF02-09) and
   Project of New Century 551 Talent Nurturing in Wenzhou. GT is supported
   in part by grants from the University School of Medicine of Verona,
   Verona, Italy. CDB is supported in part by the Southampton NIHR
   Biomedical Research Centre (IS-BRC-20004), UK.
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NR 64
TC 55
Z9 58
U1 4
U2 62
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1478-3223
EI 1478-3231
J9 LIVER INT
JI Liver Int.
PD JUL
PY 2022
VL 42
IS 7
BP 1496
EP 1502
DI 10.1111/liv.15163
EA JAN 2022
PG 7
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 2H8AI
UT WOS:000745853000001
PM 35007392
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Paoli, A
   Bianco, A
   Damiani, E
   Bosco, G
AF Paoli, Antonio
   Bianco, Antonino
   Damiani, Ernesto
   Bosco, Gerardo
TI Ketogenic Diet in Neuromuscular and Neurodegenerative Diseases
SO BIOMED RESEARCH INTERNATIONAL
LA English
DT Review
ID AMYOTROPHIC-LATERAL-SCLEROSIS; KETONE-BODIES; BETA-HYDROXYBUTYRATE;
   CARBOHYDRATE RESTRICTION; MITOCHONDRIAL BIOGENESIS; MEDITERRANEAN DIET;
   DIABETES-MELLITUS; MOUSE MODEL; WEIGHT-LOSS; ALZHEIMERS
AB An increasing number of data demonstrate the utility of ketogenic diets in a variety of metabolic diseases as obesity, metabolic syndrome, and diabetes. In regard to neurological disorders, ketogenic diet is recognized as an effective treatment for pharmacoresistant epilepsy but emerging data suggests that ketogenic diet could be also useful in amyotrophic lateral sclerosis, Alzheimer, Parkinson's disease, and some mitochondriopathies. Although these diseases have different pathogenesis and features, there are some common mechanisms that could explain the effects of ketogenic diets. These mechanisms are to provide an efficient source of energy for the treatment of certain types of neurodegenerative diseases characterized by focal brain hypometabolism; to decrease the oxidative damage associated with various kinds of metabolic stress; to increase the mitochondrial biogenesis pathways; and to take advantage of the capacity of ketones to bypass the defect in complex I activity implicated in some neurological diseases. These mechanisms will be discussed in this review.
C1 [Paoli, Antonio; Damiani, Ernesto; Bosco, Gerardo] Univ Padua, Dept Biomed Sci, I-35031 Padua, Italy.
   [Bianco, Antonino] Univ Palermo, Sport & Exercise Sci Res Unit, I-90146 Palermo, Italy.
C3 University of Padua; University of Palermo
RP Paoli, A (corresponding author), Univ Padua, Dept Biomed Sci, Via Marzolo 3, I-35031 Padua, Italy.
EM antonio.paoli@unipd.it
RI BOSCO, GERARDO/LMO-6442-2024; Bianco, Antonino/AAB-8023-2020; damiani,
   ernesto/J-6060-2012; Bianco, Antonino/AAI-7451-2020; Paoli,
   Antonio/A-6151-2015
OI Bianco, Antonino/0000-0001-8334-6581; BOSCO,
   GERARDO/0000-0001-6595-7944; Paoli, Antonio/0000-0003-0474-4229
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NR 107
TC 156
Z9 172
U1 0
U2 50
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2314-6133
EI 2314-6141
J9 BIOMED RES INT
JI Biomed Res. Int.
PY 2014
VL 2014
AR 474296
DI 10.1155/2014/474296
PG 10
WC Biotechnology & Applied Microbiology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Research & Experimental Medicine
GA AL1DS
UT WOS:000338866600001
PM 25101284
OA Green Published, Green Submitted, hybrid
DA 2025-06-11
ER

PT J
AU Tekin, G
   Tekin, YK
   Senarslan, DA
   Gocmen, AY
   Senarslan, O
   Erbay, AR
AF Tekin, Gulacan
   Tekin, Yusuf Kenan
   Senarslan, Dilsad Amanvermez
   Gocmen, Ayse Yesim
   Senarslan, Omer
   Erbay, Ali Riza
TI Serum γ-Glutamyltransferase Activity in Patients With Nonvalvular Atrial
   Fibrillation
SO ANGIOLOGY
LA English
DT Article
DE atrial fibrillation; gamma-glutamyltransferase; inflammation
ID C-REACTIVE PROTEIN; OXIDATIVE STRESS MARKERS; CARDIOVASCULAR-DISEASE;
   RISK-FACTOR; PLATELET ACTIVATION; METABOLIC SYNDROME; INFLAMMATION;
   MORTALITY; ADULTS; GLUTAMYLTRANSFERASE
AB Procoagulant and prothrombotic states in patients with chronic atrial fibrillation (AF) are higher than those in patients with normal sinus rhythm. We assessed and compared serum gamma-glutamyltranferase (GGT) activity in elderly patients with nonvalvular AF and control participants with normal sinus rhythm. Consecutive patients (n = 81) with nonvalvular chronic AF and 210 age- and gender-matched control participants with normal sinus rhythm were retrospectively included in the study from the outpatient cardiology clinic. Presence of coronary artery disease, hypertension, gender, hyperlipidemia, diabetes mellitus, smoking status, glucose, total cholesterol, triglycerides, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and ejection fraction were comparable between the 2 groups (P > .05 for all). However, serum gamma-GGT activity was significantly higher (P = .003) in patients with AF compared with those without AF. We have shown that serum gamma-GGT activity is independently associated with chronic nonvalvular AF.
C1 [Tekin, Gulacan; Erbay, Ali Riza] Bozok Univ, Fac Med, Dept Cardiol, TR-66100 Yozgat, Turkey.
   [Tekin, Yusuf Kenan] Govt Hosp, Emergency Dept, Yozgat, Turkey.
   [Senarslan, Dilsad Amanvermez] Bozok Univ, Fac Med, Dept Cardiovasc Surg, TR-66100 Yozgat, Turkey.
   [Gocmen, Ayse Yesim] Bozok Univ, Fac Med, Dept Biochem, TR-66100 Yozgat, Turkey.
   [Senarslan, Omer] Govt Hosp, Dept Cardiol, Yozgat, Turkey.
C3 Bozok University; Van Gevas State Hospital; Bozok University; Bozok
   University; Van Gevas State Hospital
RP Tekin, G (corresponding author), Bozok Univ, Fac Med, Dept Cardiol, TR-66100 Yozgat, Turkey.
EM gulacantekin@hotmail.com
RI Kurt, Gokce/HQY-3864-2023; Tekin, Yusuf/AAH-7137-2019; AMANVERMEZ
   SENARSLAN, DILSAD/AAB-8021-2019
OI Amanvermez Senarslan, Dilsad/0000-0002-3316-6707
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NR 39
TC 9
Z9 9
U1 0
U2 6
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0003-3197
J9 ANGIOLOGY
JI Angiology
PD FEB
PY 2013
VL 64
IS 2
BP 157
EP 160
DI 10.1177/0003319712438956
PG 4
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 072BG
UT WOS:000313642600012
PM 22492250
DA 2025-06-11
ER

PT J
AU Singh, R
   Kaushik, S
   Wang, YJ
   Xiang, YQ
   Novak, I
   Komatsu, M
   Tanaka, K
   Cuervo, AM
   Czaja, MJ
AF Singh, Rajat
   Kaushik, Susmita
   Wang, Yongjun
   Xiang, Youqing
   Novak, Inna
   Komatsu, Masaaki
   Tanaka, Keiji
   Cuervo, Ana Maria
   Czaja, Mark J.
TI Autophagy regulates lipid metabolism
SO NATURE
LA English
DT Article
ID LOW-DENSITY-LIPOPROTEIN; PHOSPHATIDYLINOSITOL 3-KINASE; TRIACYLGLYCEROL;
   LIPOLYSIS; DISEASE; STRESS; CYP2E1; ROLES; LIVER
AB The intracellular storage and utilization of lipids are critical to maintain cellular energy homeostasis. During nutrient deprivation, cellular lipids stored as triglycerides in lipid droplets are hydrolysed into fatty acids for energy. A second cellular response to starvation is the induction of autophagy, which delivers intracellular proteins and organelles sequestered in double-membrane vesicles (autophagosomes) to lysosomes for degradation and use as an energy source. Lipolysis and autophagy share similarities in regulation and function but are not known to be interrelated. Here we show a previously unknown function for autophagy in regulating intracellular lipid stores (macrolipophagy). Lipid droplets and autophagic components associated during nutrient deprivation, and inhibition of autophagy in cultured hepatocytes and mouse liver increased triglyceride storage in lipid droplets. This study identifies a critical function for autophagy in lipid metabolism that could have important implications for human diseases with lipid over-accumulation such as those that comprise the metabolic syndrome.
C1 [Singh, Rajat; Kaushik, Susmita; Wang, Yongjun; Xiang, Youqing; Cuervo, Ana Maria; Czaja, Mark J.] Albert Einstein Coll Med, Dept Med, Bronx, NY 10461 USA.
   [Singh, Rajat; Kaushik, Susmita; Wang, Yongjun; Xiang, Youqing; Novak, Inna; Cuervo, Ana Maria; Czaja, Mark J.] Albert Einstein Coll Med, Marion Bessin Liver Res Ctr, Bronx, NY 10461 USA.
   [Kaushik, Susmita; Cuervo, Ana Maria] Albert Einstein Coll Med, Dept Dev & Mol Biol, Bronx, NY 10461 USA.
   [Kaushik, Susmita; Cuervo, Ana Maria] Albert Einstein Coll Med, Inst Aging Studies, Bronx, NY 10461 USA.
   [Novak, Inna] Albert Einstein Coll Med, Dept Pediat, Bronx, NY 10461 USA.
   [Komatsu, Masaaki; Tanaka, Keiji] Tokyo Metropolitan Inst Med Sci, Lab Frontier Sci, Bunkyo Ku, Tokyo 1138613, Japan.
C3 Montefiore Medical Center; Albert Einstein College of Medicine; Yeshiva
   University; Yeshiva University; Montefiore Medical Center; Albert
   Einstein College of Medicine; Yeshiva University; Montefiore Medical
   Center; Albert Einstein College of Medicine; Yeshiva University;
   Montefiore Medical Center; Albert Einstein College of Medicine;
   Montefiore Medical Center; Albert Einstein College of Medicine; Yeshiva
   University; Tokyo Metropolitan Institute of Medical Science
RP Czaja, MJ (corresponding author), Albert Einstein Coll Med, Dept Med, 1300 Morris Pk Ave, Bronx, NY 10461 USA.
EM amcuervo@aecom.yu.edu; czaja@aecom.yu.edu
RI SINGH, RAJAT/JPK-6888-2023; Novak, Inna/ABF-9575-2020; Tanaka,
   Keiji/AEJ-6362-2022; Komatsu, Masaaki/B-8321-2011; Kaushik,
   Susmita/GVS-3186-2022
OI Cuervo, Ana Maria/0000-0002-0771-700X; Komatsu,
   Masaaki/0000-0001-7672-7722; Kaushik, Susmita/0000-0002-6096-5387;
   Novak, Inna/0000-0003-0839-8298
FU National Institute of Diabetes and Digestive and Kidney Diseases;
   National Institute on Aging; American Liver Foundation Postdoctoral
   Research Fellowship Award
FX We thank D. Silver for his discussions, N. Mizushima for providing the
   Atg5<SUP>-/-</SUP> mouse embryonic fibroblasts, R. Stockert for the
   protein disulphide isomerase antibody and the personnel at the
   Analytical Imaging Facility for their technical assistance. This work
   was supported by National Institutes of Health grants from the National
   Institute of Diabetes and Digestive and Kidney Diseases and National
   Institute on Aging, a Glenn Award and an American Liver Foundation
   Postdoctoral Research Fellowship Award (R.S.).
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NR 35
TC 3132
Z9 3501
U1 26
U2 685
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0028-0836
EI 1476-4687
J9 NATURE
JI Nature
PD APR 30
PY 2009
VL 458
IS 7242
BP 1131
EP U64
DI 10.1038/nature07976
PG 7
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 441FL
UT WOS:000265754600039
PM 19339967
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Delrue, C
   Speeckaert, R
   Delanghe, JR
   Prytula, A
   Speeckaert, MM
AF Delrue, Charlotte
   Speeckaert, Reinhart
   Delanghe, Joris R.
   Prytula, Agnieszka
   Speeckaert, Marijn M.
TI Investigating Vitamin D-Binding Protein's Role in Childhood Health and
   Development
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE children; polymorphisms; vitamin D-binding protein
ID 25-HYDROXYVITAMIN D LEVELS; AMINO-ACID VARIANTS; GENE POLYMORPHISMS;
   METABOLIC SYNDROME; OXIDATIVE STRESS; ADIPOSE-TISSUE; OBESE CHILDREN;
   DBP GENE; ASSOCIATION; SUPPLEMENTATION
AB Vitamin D-binding protein (DBP), also known as Gc-globulin, is a protein that affects several physiological processes, including the transport and regulation of vitamin D metabolites. Genetic polymorphisms in the DBP gene have a significant impact on vitamin D levels and may have implications for disease risk. DBP polymorphisms are linked to differential immune responses, which could influence the onset of juvenile diseases. This narrative review examines the various roles of DBP, with a focus on bone health, immunological regulation, and lipid metabolism in children. Chronic disorders affected by DBP polymorphisms include bone abnormalities, autoimmune diseases, cardiovascular issues, childhood asthma, allergies, cystic fibrosis, acute liver failure, celiac disease, inflammatory bowel disease, and chronic kidney disease. Future research should focus on identifying the processes that underpin the many roles that DBP plays and developing customized therapeutics to improve health outcomes in the juvenile population.
C1 [Delrue, Charlotte; Speeckaert, Marijn M.] Ghent Univ Hosp, Dept Nephrol, B-9000 Ghent, Belgium.
   [Speeckaert, Reinhart] Ghent Univ Hosp, Dept Dermatol, B-9000 Ghent, Belgium.
   [Delanghe, Joris R.] Univ Ghent, Dept Diag Sci, B-9000 Ghent, Belgium.
   [Prytula, Agnieszka] Ghent Univ Hosp, Dept Pediat, B-9000 Ghent, Belgium.
   [Speeckaert, Marijn M.] Res Fdn Flanders FWO, B-1000 Brussels, Belgium.
C3 Ghent University; Ghent University Hospital; Ghent University; Ghent
   University Hospital; Ghent University; Ghent University; Ghent
   University Hospital
RP Speeckaert, MM (corresponding author), Ghent Univ Hosp, Dept Nephrol, B-9000 Ghent, Belgium.; Speeckaert, MM (corresponding author), Res Fdn Flanders FWO, B-1000 Brussels, Belgium.
EM charlotte.delrue@ugent.be; reinhart.speeckaert@uzgent.be;
   joris.delanghe@ugent.be; agnieszka.prytula@uzgent.be;
   marijn.speeckaert@ugent.be
RI Speeckaert, Marijn/HPB-8611-2023; Prytula, Agnieszka/N-8036-2015
OI Delanghe, Joris/0000-0002-5702-6792; Speeckaert,
   Marijn/0000-0001-9183-4390; Prytula, Agnieszka/0000-0001-9551-8758
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NR 79
TC 1
Z9 1
U1 3
U2 3
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD JUN
PY 2024
VL 25
IS 11
AR 6272
DI 10.3390/ijms25116272
PG 17
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA UC0P7
UT WOS:001245748500001
PM 38892458
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Huang, YZ
   Hu, JJ
   Xia, QJ
   Tang, MM
   Wang, YX
   Wang, GC
   Shao, XY
   Yuan, H
   Li, SH
   Huang, P
   Peng, CJ
   Guo, J
   Gui, SY
AF Huang, Yuzhe
   Hu, Jingjing
   Xia, Qijun
   Tang, Maomao
   Wang, Yuxiao
   Wang, Guichun
   Shao, Xinyuan
   Yuan, Hao
   Li, Shuhan
   Huang, Peng
   Peng, Chengjun
   Guo, Jian
   Gui, Shuangying
TI Amelioration of obesity and inflammation by polysaccharide from unripe
   fruits of raspberry via gut microbiota regulation
SO INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
LA English
DT Article
DE Raspberry polysaccharide; Obesity; Inflammation; Intestinal barrier
   function; Gut microbiota
ID RUBUS-CHINGII HU; ULCERATIVE-COLITIS; OXIDATIVE STRESS; IMPACT
AB Raspberry, a traditional medicine food homology species, has important benefits in patients with metabolic syndrome. However, the mechanism of raspberry polysaccharides (RP) on obesity remains unclear. In our study, we showed that RP intervention is negatively associated with body weight gain, hyperlipidemia, inflammation, and fat accumulation in obese mice. RP ameliorated HFD-induced gut microbiota dysbiosis, produced short-chain fatty acids, maintained intestinal barrier integrity, and prevented metabolic endotoxemia, manifested by decreased host lipopolysaccharide level, and increased colon expression of tight junction proteins. These effects might be related with driven by a SCFAs-producing bacterium and downregulation of TLR4/NF-kappa B signaling transduction. Notably, the abundance of Ruminococcaceae_UCG - 014, Lactobacillus taiwanensis, Bifidobacterium pseudolongum, and Turicibacter are markedly correlated with enhanced intestinal barrier function induced by RP treatment. Thus, we believe that RP could be as a potential health supplement or prebiotic for obesity therapy.
C1 [Huang, Yuzhe; Hu, Jingjing; Xia, Qijun; Tang, Maomao; Wang, Yuxiao; Wang, Guichun; Shao, Xinyuan; Yuan, Hao; Li, Shuhan; Peng, Chengjun; Guo, Jian; Gui, Shuangying] Anhui Univ Chinese Med, Dept Pharm, Hefei 230012, Anhui, Peoples R China.
   [Huang, Yuzhe; Peng, Chengjun; Guo, Jian; Gui, Shuangying] Anhui Acad Chinese Med, Inst Pharmaceut, Hefei 230012, Anhui, Peoples R China.
   [Huang, Yuzhe; Peng, Chengjun; Guo, Jian; Gui, Shuangying] Anhui Prov Key Lab Pharmaceut Preparat Technol & A, Hefei 230012, Anhui, Peoples R China.
   [Gui, Shuangying] Anhui Univ Chinese Med, Ctr Xinan Med & Modernizat Tradit Chinese Med IHM, Hefei 230012, Peoples R China.
   [Huang, Peng] Anhui Univ Tradit Chinese Med, Dept Neurol, Affiliated Hosp 1, Hefei 230031, Anhui, Peoples R China.
C3 Anhui University of Chinese Medicine; Anhui University of Chinese
   Medicine; Anhui University of Chinese Medicine; Anhui University of
   Chinese Medicine
RP Gui, SY (corresponding author), Anhui Univ Chinese Med, Dept Pharm, Hefei 230012, Anhui, Peoples R China.
EM guishy0520@126.com
RI Guo, Jian/LXB-0445-2024; Wang, Jianming/HGA-5239-2022
FU National Natural Science Foundation of China [81873019]; University
   Synergy Innovation Programme of Anhui Province [GXXT-2020-025]; The
   Inheritance and Innovation Project of North Huatuo and South Xin'an
   [2022BHTNXA04]; Anhui Provincial Program on Key Research and Development
   Project, China [202204295107020039]; High-level Talent Support Program
   of Anhui University of Chinese Medicine [2023rczd002]
FX This study was funded by the National Natural Science Foundation of
   China (No. 81873019) ; The University Synergy Innovation Programme of
   Anhui Province (GXXT-2020-025) ; The Inheritance and Innovation Project
   of North Huatuo and South Xin'an (2022BHTNXA04) ; The Anhui Provincial
   Program on Key Research and Development Project, China (No.
   202204295107020039) and the High-level Talent Support Program of Anhui
   University of Chinese Medicine (No. 2023rczd002) .
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NR 42
TC 15
Z9 19
U1 23
U2 73
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0141-8130
EI 1879-0003
J9 INT J BIOL MACROMOL
JI Int. J. Biol. Macromol.
PD MAR
PY 2024
VL 261
AR 129825
DI 10.1016/j.ijbiomac.2024.129825
EA FEB 2024
PN 2
PG 14
WC Biochemistry & Molecular Biology; Chemistry, Applied; Polymer Science
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry; Polymer Science
GA JX9C6
UT WOS:001176566800001
PM 38309402
DA 2025-06-11
ER

PT J
AU Shaukat, H
   Ali, A
   Zhang, Y
   Ahmad, A
   Riaz, S
   Khan, A
   Mehany, T
   Qin, H
AF Shaukat, Horia
   Ali, Anwar
   Zhang, Yang
   Ahmad, Arslan
   Riaz, Sakhawat
   Khan, Ahmal
   Mehany, Taha
   Qin, Hong
TI Tea polyphenols: extraction techniques and its potency as a
   nutraceutical
SO FRONTIERS IN SUSTAINABLE FOOD SYSTEMS
LA English
DT Review
DE tea-polyphenols; extraction techniques; antioxidants; nutraceuticals;
   diseases
ID HOT-WATER EXTRACTION; GREEN TEA; BLACK-TEA; BIOLOGICAL-ACTIVITIES;
   ANTIOXIDANT CAPACITY; BIOACTIVE COMPONENTS; METABOLIC SYNDROME; HEALTH;
   FAT; CATECHINS
AB Usually, polyphenols help address numerous health issues caused by oxidative stress. Tea is a popular beverage (rich in polyphenols) with abundant health promoting and disease prevention with great health-promoting and disease-prevention attributes, originating from the delicate, dried leaves of the Camellia sinensis plant. Tea has been proven to have health-boosting impacts like anti-inflammatory, anti-cancerous, anti-diabetic, and aids in weight loss. Cognitive impairment, also known as cognitive decline caused by aging or other neurological disorders, has become an emerging health concern. Tea polyphenols, especially phenolic acids, havegained enormous attention due to their link to improved cognitive function by preventing cognitive decline. This review summarizes recent studies on the health benefits of polyphenols in tea. Additionally, effective traditional and modern techniques to extract polyphenols and their effects on various diseases have been described.
C1 [Shaukat, Horia; Ali, Anwar; Qin, Hong] Cent South Univ, Xiangya Sch Publ Hlth, Changsha, Peoples R China.
   [Zhang, Yang] Hunan First Normal Univ, Coll Phys Educ, Changsha, Peoples R China.
   [Ahmad, Arslan; Riaz, Sakhawat] Govt Coll Univ, Dept Home Econ, Faisalabad, Pakistan.
   [Khan, Ahmal] Govt Coll Univ, Dept Food Sci, Faisalabad, Pakistan.
   [Mehany, Taha] City Sci Res & Technol Applicat, Arid Lands Cultivat Res Inst, Food Technol Dept, Alexandria, Egypt.
   [Mehany, Taha] Univ La Rioja, Dept Chem, Logrono, Spain.
C3 Central South University; Hunan First Normal University; Government
   College University Faisalabad; Government College University Faisalabad;
   Egyptian Knowledge Bank (EKB); City of Scientific Research &
   Technological Applications (SRTA-City); Universidad de La Rioja
RP Qin, H (corresponding author), Cent South Univ, Xiangya Sch Publ Hlth, Changsha, Peoples R China.; Zhang, Y (corresponding author), Hunan First Normal Univ, Coll Phys Educ, Changsha, Peoples R China.
EM qingfeng198410@163.com; qinhong@csu.edu.cn
RI Qin, Hong/HLX-4770-2023; ALI, ANWAR/ADP-3857-2022; Mehany,
   Taha/E-8302-2019
OI Mehany, Taha/0000-0001-7960-7558
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NR 208
TC 13
Z9 13
U1 24
U2 99
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 2571-581X
J9 FRONT SUSTAIN FOOD S
JI Front. Sustain. Food Syst.
PD MAY 24
PY 2023
VL 7
AR 1175893
DI 10.3389/fsufs.2023.1175893
PG 17
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA I4AE6
UT WOS:001002213300001
OA gold
DA 2025-06-11
ER

PT J
AU Li, XY
   Wang, H
AF Li, Xiaoyan
   Wang, Hua
TI Multiple organs involved in the pathogenesis of non-alcoholic fatty
   liver disease
SO CELL AND BIOSCIENCE
LA English
DT Review
DE Non-alcoholic fatty liver disease; Energy metabolism; Lipid; Hormone;
   Inter-organ crosstalk
ID BROWN ADIPOSE-TISSUE; DIET-INDUCED OBESITY; GROWTH-FACTOR 21;
   ENDOPLASMIC-RETICULUM STRESS; HEPATIC LIPID-METABOLISM;
   RECEPTOR-DEFICIENT MICE; INSULIN-RESISTANCE; GUT MICROBIOTA;
   ENERGY-METABOLISM; EXTRAHEPATIC COMPLICATIONS
AB Non-alcoholic fatty liver disease (NAFLD) represents the leading cause of chronic liver disease worldwide and the anticipated health burden is huge. There are limited therapeutic approaches for NAFLD now. It's imperative to get a better understanding of the disease pathogenesis if new treatments are to be discovered. As the hepatic manifestation of metabolic syndrome, this disease involves complex interactions between different organs and regulatory pathways. It's increasingly clear that brain, gut and adipose tissue all contribute to NAFLD pathogenesis and development, in view of their roles in energy homeostasis. In the present review, we try to summarize currently available data regarding NAFLD pathogenesis and to lay a particular emphasis on the inter-organ crosstalk evidence.
C1 [Li, Xiaoyan; Wang, Hua] Anhui Med Univ, Affiliated Hosp 1, Dept Oncol, Hefei 230022, Peoples R China.
   [Wang, Hua] Inflammat & Immune Mediated Dis Lab Anhui Prov, Hefei 230032, Peoples R China.
C3 Anhui Medical University
RP Wang, H (corresponding author), Anhui Med Univ, Affiliated Hosp 1, Dept Oncol, Hefei 230022, Peoples R China.; Wang, H (corresponding author), Inflammat & Immune Mediated Dis Lab Anhui Prov, Hefei 230032, Peoples R China.
EM wanghua@ahmu.edu.cn
RI Wang, Zhouheng/GZM-3853-2022
OI Wang, Hua/0000-0002-2605-5697
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NR 216
TC 26
Z9 28
U1 1
U2 22
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 2045-3701
J9 CELL BIOSCI
JI Cell Biosci.
PD DEC 7
PY 2020
VL 10
IS 1
AR 140
DI 10.1186/s13578-020-00507-y
PG 15
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA PC4BB
UT WOS:000596947700001
PM 33372630
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Brennan, P
   Clare, K
   George, J
   Dillon, JF
AF Brennan, Paul
   Clare, Kathleen
   George, Jacob
   Dillon, John F.
TI Determining the role for uric acid in non-alcoholic steatohepatitis
   development and the utility of urate metabolites in diagnosis: An
   opinion review
SO WORLD JOURNAL OF GASTROENTEROLOGY
LA English
DT Review
DE Non-alcoholic fatty liver disease; Non-alcoholic steatohepatitis; Uric
   acid; Urate; Non-invasive fibrosis markers; Fatty liver index
ID FATTY LIVER-DISEASE; ENDOPLASMIC-RETICULUM STRESS; XANTHINE-OXIDASE;
   HEPATIC STEATOSIS; POPULATION; PREVALENCE; ACTIVATION; GENERATION;
   SEVERITY; NONOBESE
AB There has long been a recognised association between non-alcoholic fatty liver disease (NAFLD) and the composite aspects of the metabolic syndrome. Part of this association highlighted the supposed co-existence of elevated uric acid levels in those with NAFLD. There is interest in exploitation of this as a putative diagnostic and prognostic biomarker in NAFLD. Given the increased economic and health burden associated with the NAFLD epidemic, improved methods of population-based, minimally-invasive methods and biomarkers are clearly highly sought and necessary. In this opinion review we review the proposed role of uric acid in the pathogenesis of NAFLD and its potential utilisation in the diagnosis and monitoring of the disease process.
C1 [Brennan, Paul; George, Jacob; Dillon, John F.] Univ Dundee, Ninewells Hosp & Med Sch, Dept Mol & Clin Med, Kirsty Semple Way, Dundee DD1 9SY, Scotland.
   [Clare, Kathleen] Queen Elizabeth Hosp, Dept Neurol, Glasgow G51 4TF, Lanark, Scotland.
C3 University of Dundee
RP Brennan, P (corresponding author), Univ Dundee, Ninewells Hosp & Med Sch, Dept Mol & Clin Med, Kirsty Semple Way, Dundee DD1 9SY, Scotland.
EM p.z.brennan@dundee.ac.uk
RI Dillon, John/A-2478-2013; Brennan, Paul/ABG-5361-2020
OI Dillon, John/0000-0002-2164-4476; Brennan, Paul/0000-0001-8368-1478;
   George, Jacob/0000-0001-8154-8278
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NR 42
TC 16
Z9 17
U1 2
U2 19
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 7041 Koll Center Parkway, Suite 160, PLEASANTON, CA, UNITED STATES
SN 1007-9327
EI 2219-2840
J9 WORLD J GASTROENTERO
JI World J. Gastroenterol.
PD APR 21
PY 2020
VL 26
IS 15
BP 1683
EP 1690
DI 10.3748/wjg.v26.i15.1683
PG 8
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA LS3CS
UT WOS:000536265800001
PM 32351286
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Hernández-Alonso, P
   Camacho-Barcia, L
   Bulló, M
   Salas-Salvadó, J
AF Hernandez-Alonso, Pablo
   Camacho-Barcia, Lucia
   Bullo, Monica
   Salas-Salvado, Jordi
TI Nuts and Dried Fruits: An Update of Their Beneficial Effects on Type 2
   Diabetes
SO NUTRIENTS
LA English
DT Review
DE diabetes; nuts; dried fruits; insulin resistance; mechanisms; clinical
   trials
ID NUTRITION EXAMINATION SURVEY; CARDIOVASCULAR RISK-FACTORS; RANDOMIZED
   CONTROLLED-TRIAL; ALPHA-MEDIATED INFLAMMATION; BLOOD MONONUCLEAR-CELLS;
   ADULTS NATIONAL-HEALTH; INSULIN-RESISTANCE; OXIDATIVE STRESS; GUT
   MICROBIOTA; PISTACHIO CONSUMPTION
AB Nuts and dried fruit are essential foods in the Mediterranean diet. Their frequent consumption has been associated with the prevention and/or the management of such metabolic conditions as type 2 diabetes (T2D), metabolic syndrome and cardiovascular diseases. Several previous reviews of epidemiological studies and clinical trials have evaluated the associations of nuts and/or dried fruit with various metabolic disorders. However, no reviews have focused on the mechanisms underlying the role of nuts and/or dried fruit in insulin resistance and T2D. This review aims to report nut and dried-fruit nutritional interventions in animals and humans, and to focus on mechanisms that could play a significant role in the prevention and treatment of insulin resistance and T2D.
C1 [Hernandez-Alonso, Pablo; Camacho-Barcia, Lucia; Bullo, Monica; Salas-Salvado, Jordi] Univ Rovira & Virgili, Univ Hosp St Joan de Reus, Human Nutr Unit, Biochem & Biotechnol Dept,Fac Med & Hlth Sci,IISP, St St Llorenc 21, Reus 43201, Spain.
   [Hernandez-Alonso, Pablo; Camacho-Barcia, Lucia; Bullo, Monica; Salas-Salvado, Jordi] Inst Salud Carlos III, CIBERobn Physiopathol Obes & Nutr, Madrid 28029, Spain.
C3 Universitat Rovira i Virgili; CIBER - Centro de Investigacion Biomedica
   en Red; CIBEROBN; Instituto de Salud Carlos III
RP Bulló, M; Salas-Salvadó, J (corresponding author), Univ Rovira & Virgili, Univ Hosp St Joan de Reus, Human Nutr Unit, Biochem & Biotechnol Dept,Fac Med & Hlth Sci,IISP, St St Llorenc 21, Reus 43201, Spain.; Bulló, M; Salas-Salvadó, J (corresponding author), Inst Salud Carlos III, CIBERobn Physiopathol Obes & Nutr, Madrid 28029, Spain.
EM pablo1280@gmail.com; marialucia.camacho@urv.cat; monica.bullo@urv.cat;
   jordi.salas@urv.cat
RI Salas-Salvado, Jordi/C-7229-2017; Bullo, Monica/F-2925-2016;
   Hernandez-Alonso, Pablo/Q-1090-2018; Camacho-Barcia, Lucia/AAB-2096-2021
OI Salas-Salvado, Jordi/0000-0003-2700-7459; Bullo,
   Monica/0000-0002-0218-7046; Hernandez-Alonso, Pablo/0000-0002-9977-8976;
   Camacho-Barcia, Lucia/0000-0002-5989-936X
FU Generalitat de Catalunya's Department of Universities (FI-DGR)
FX We thank Carles Munne and Susana Segura (Universitat Rovira i Virgili)
   for their help as editor assistance. Lucia Camacho-Barcia is the
   recipient of a pre-doctoral fellowship from the Generalitat de
   Catalunya's Department of Universities (FI-DGR 2017).
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NR 170
TC 67
Z9 74
U1 0
U2 38
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JUL
PY 2017
VL 9
IS 7
AR 673
DI 10.3390/nu9070673
PG 34
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA FC2PF
UT WOS:000406679700030
PM 28657613
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Chagas, VT
   França, LM
   Malik, S
   Paes, AMD
AF Chagas, Vinicyus Teles
   Franca, Lucas Martins
   Malik, Sonia
   de Andrade Paes, Antonio Marcus
TI Syzygium cumini (L.) skeels: a prominent source of bioactive
   molecules against cardiometabolic diseases
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Review
DE black plum; jamun; myrtaceae; phenolic compounds; metabolic syndrome;
   ethnopharmacology; medicinal plants; complementary and alternative
   medicine
ID AMELIORATES INSULIN-RESISTANCE; FLAVONOID-RICH EXTRACT; PPAR-GAMMA;
   PHENOLIC CONSTITUENTS; ANTIOXIDANT ACTIVITY; DIABETES-MELLITUS;
   OXIDATIVE STRESS; MYRTACEAE; SEEDS; ACTIVATION
AB Syzygium cumini (Myrtaceae) is a worldwide medicinal plant traditionally used in herbal medicines due to its vaunted properties against cardiometabolic disorders, which include: antihyperglycemic, hypolipemiant, antiinflammatory, cardioprotective, and antioxidant activities. These properties have been attributed to the presence of bioactive compounds such as phenols, flavonoids, and tannins in different parts of the plant, albeit the knowledge on their mechanisms of action is scarce. This mini review highlights the cardiometabolic properties of S. cumini by correlating its already identified phytochemicals with their described mechanisms of action. Data herein compiled show that some compounds target multiple metabolic pathways; thereby, becoming potential pharmacological tools. Moreover, the lack of clinical trials on S. cumini usage makes it a fruitful field of interest for both scientific community and pharmaceutical industry.
C1 [Chagas, Vinicyus Teles; Franca, Lucas Martins; de Andrade Paes, Antonio Marcus] Univ Fed Maranhao, Dept Physiol Sci, Lab Expt Physiol, Sao Luis, Brazil.
   [Chagas, Vinicyus Teles; Franca, Lucas Martins; Malik, Sonia; de Andrade Paes, Antonio Marcus] Univ Fed Maranhao, Biol & Hlth Sci Ctr, Grad Program Hlth Sci, Sao Luis, Brazil.
C3 Universidade Federal do Maranhao; Universidade Federal do Maranhao
RP Paes, AMD (corresponding author), Univ Fed Maranhao, Dept Physiol Sci, Lab Expt Physiol, Sao Luis, Brazil.
EM marcuspaes@ufma.br
RI França, Lucas/IAM-5986-2023; Paes, Antonio/C-7174-2013; Malik,
   Sonia/L-7003-2019; Malik, Sonia/Q-2974-2017
OI Martins Franca, Lucas/0000-0002-4412-1539; Malik,
   Sonia/0000-0001-5224-3838
FU Foundation for the Support of Research, Scientific, and Technological
   Development of the State of Maranhao - FAPEMA [APP01128/10, APP00280/12]
FX Authors are thankful to Foundation for the Support of Research,
   Scientific, and Technological Development of the State of Maranhao -
   FAPEMA, which has importantly funded their research on pharmacological
   properties of S. cumini through the grants #APP01128/10 and
   #APP00280/12. We are also thankful to Victor Cardoso for his support on
   the figure drawing.
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TC 64
Z9 72
U1 1
U2 15
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD NOV 3
PY 2015
VL 6
AR 259
DI 10.3389/fphar.2015.00259
PG 8
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA CY0UZ
UT WOS:000366123400001
PM 26578965
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Sharma, H
   Swetanshu
   Singh, P
AF Sharma, Harshita
   Swetanshu
   Singh, Pratichi
TI Role of Yoga in Cardiovascular Diseases
SO CURRENT PROBLEMS IN CARDIOLOGY
LA English
DT Review
ID BLOOD-PRESSURE; SMOKING-CESSATION; RISK-FACTORS; HATHA YOGA;
   COMPLEMENTARY; INTERVENTIONS; MEDITATION
AB Cardiovascular diseases are a collection of conditions that affect the blood vessels and the heart. These conditions include cardiac rehabilitation, hypertension, cardiac failure, rheumatic heart disease, peripheral artery disease, and coronary heart disease. Poor nutrition, alcohol, lack of exercise, smoking, etc are the main behavioral risk factors for heart disease. This study delivers a methodical review of yoga's role in the management and inhibition of cardiovascular diseases and their associated risk factors. This review suggests that proper maintenance of fitness and stress employing yoga effectively lowers cardiovascular disease. In this review, various asanas, and pranayama like Marjaryasana, Kapalabhati, Halasana, etc have been discussed. Also, their role in the prevention of coronary heart disease (CHD). In addition to this different metabolic syndrome associated with cardiovascular diseases and the relation of yoga with hypertension has been discussed. The review has documented satisfactory proof and concludes that yogic exercise enhances cardiovascular health and reduces associated risk factors.
C1 [Sharma, Harshita; Swetanshu; Singh, Pratichi] Galgotias Univ, Sch Biol & Life Sci, Greater Noida 203201, Uttar Pradesh, India.
C3 Galgotias University
RP Singh, P (corresponding author), Galgotias Univ, Sch Biol & Life Sci, Greater Noida 203201, Uttar Pradesh, India.
EM singhpratichi29@gmail.com
RI Singh, Harshita/HJZ-1037-2023
OI , Swetanshu/0000-0003-3604-1499; Singh, Pratichi/0000-0002-8163-355X
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TC 5
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U1 1
U2 13
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0146-2806
EI 1535-6280
J9 CURR PROB CARDIOLOGY
JI Curr. Probl. Cardiol.
PD JAN
PY 2024
VL 49
IS 1
AR 102032
DI 10.1016/j.cpcardiol.2023.102032
EA SEP 2023
PN A
PG 18
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA T3WJ0
UT WOS:001077320100001
PM 37582455
DA 2025-06-11
ER

PT J
AU Levine, DC
   Hong, H
   Weidemann, BJ
   Ramsey, KM
   Affinati, AH
   Schmidt, MS
   Cedernaes, J
   Omura, C
   Braun, R
   Lee, C
   Brenner, C
   Peek, CB
   Bass, J
AF Levine, Daniel C.
   Hong, Heekyung
   Weidemann, Benjamin J.
   Ramsey, Kathryn M.
   Affinati, Alison H.
   Schmidt, Mark S.
   Cedernaes, Jonathan
   Omura, Chiaki
   Braun, Rosemary
   Lee, Choogon
   Brenner, Charles
   Peek, Clara Bien
   Bass, Joseph
TI NAD<SUP>+</SUP> Controls Circadian Reprogramming through PER2 Nuclear
   Translocation to Counter Aging
SO MOLECULAR CELL
LA English
DT Article
ID HEAT-SHOCK FACTOR-1; NICOTINAMIDE RIBOSIDE; GENE-EXPRESSION;
   MITOCHONDRIAL DYSFUNCTION; DEPENDENT INHIBITION; METABOLIC SYNDROME;
   PERIOD LOCUS; CLOCK; AGE; TEMPERATURE
AB Disrupted sleep-wake and molecular circadian rhythms are a feature of aging associated with metabolic disease and reduced levels of NAD(+), yet whether changes in nucleotide metabolism control circadian behavioral and genomic rhythms remains unknown. Here, we reveal that supplementation with the NAD(+) precursor nicotinamide riboside (NR) markedly reprograms metabolic and stress-response pathways that decline with aging through inhibition of the clock repressor PER2. NR enhances BMAL1 chromatin binding genome-wide through PER2K680 deacetylation, which in turn primes PER2 phosphorylation within a domain that controls nuclear transport and stability and that is mutated in human advanced sleep phase syndrome. In old mice, dampened BMAL1 chromatin binding, transcriptional oscillations, mitochondrial respiration rhythms, and late evening activity are restored by NAD(+) repletion to youthful levels with NR. These results reveal effects of NAD(+) on metabolism and the circadian system with aging through the spatiotemporal control of the molecular clock.
C1 [Levine, Daniel C.; Hong, Heekyung; Weidemann, Benjamin J.; Ramsey, Kathryn M.; Cedernaes, Jonathan; Omura, Chiaki; Peek, Clara Bien; Bass, Joseph] Northwestern Univ, Feinberg Sch Med, Dept Med, Div Endocrinol Metab & Mol Med, Chicago, IL 60611 USA.
   [Affinati, Alison H.] Univ Michigan, Dept Internal Med, Michigan Med, Ann Arbor, MI 48109 USA.
   [Schmidt, Mark S.; Brenner, Charles] Univ Iowa, Dept Biochem, Iowa City, IA 52242 USA.
   [Cedernaes, Jonathan] Uppsala Univ, Dept Med Sci, SE-75124 Uppsala, Sweden.
   [Braun, Rosemary] Northwestern Univ, Feinberg Sch Med, Biostat Div, Chicago, IL 60611 USA.
   [Braun, Rosemary] Northwestern Univ, Dept Engn Sci & Appl Math, Evanston, IL 60208 USA.
   [Braun, Rosemary] Northwestern Univ, NSF Simons Ctr Quantitat Biol, Evanston, IL 60208 USA.
   [Lee, Choogon] Florida State Univ, Dept Biomed Sci, Tallahassee, FL 32306 USA.
   [Peek, Clara Bien] Northwestern Univ, Dept Biochem & Mol Genet, Feinberg Sch Med, Chicago, IL 60611 USA.
C3 Northwestern University; Feinberg School of Medicine; University of
   Michigan System; University of Michigan; University of Iowa; Uppsala
   University; Northwestern University; Feinberg School of Medicine;
   Northwestern University; Northwestern University; State University
   System of Florida; Florida State University; Northwestern University;
   Feinberg School of Medicine
RP Bass, J (corresponding author), Northwestern Univ, Feinberg Sch Med, Dept Med, Div Endocrinol Metab & Mol Med, Chicago, IL 60611 USA.
EM j-bass@northwestern.edu
RI Schmidt, Michael/F-1677-2010; Cedernaes, Jonathan/AAM-3973-2021;
   Brenner, Charles/D-6339-2014
OI Bass, Joseph/0000-0002-1602-8601; Weidemann,
   Benjamin/0000-0002-3747-2744; Brenner, Charles/0000-0002-4955-3226;
   Cedernaes, Jonathan/0000-0002-9052-8372; Levine,
   Daniel/0000-0002-3453-951X; Braun, Rosemary/0000-0001-9668-9866
FU National Cancer Institute Cancer Center Support Grant, United States
   [P30 CA060553]; National Institute of Diabetes and Digestive and Kidney
   Diseases (NIDDK) [R01DK090625, R01DK100814, 1R01DK113011-01A1,
   5K01DK105137-03, 1R03DK116012-01]; Chicago Biomedical Consortium, United
   States [S-007]; National Institute on Aging (NIA) [P01AG011412];
   National Research Service Award (NRSA) [F30DK116481]; Swedish Research
   Council [2014-6888]; Swedish Society for Medical Research; National
   Institute of Neurological Disorders and Stroke (NINDS) [R21NS099813];
   National Heart, Lung, and Blood Institute (NHLBI) [R01HL147545]; Roy J.
   Carver Trust; NSF-Simons Center for Quantitative Biology (Simons
   Foundation/SFARI, United States [597491-RWC]; National Science
   Foundation [1764421];  [P41 GM108569]
FX We thank all members of the Bass, Barish, and Allada laboratories for
   helpful discussions, and Biliana Marcheva for help with the figures.
   Proteomics services were performed by the Northwestern Proteomics Core
   Facility, supported by National Cancer Institute Cancer Center Support
   Grant P30 CA060553, United States awarded to the Robert H. Lurie
   Comprehensive Cancer Center and the National Resource for Translational
   and Developmental Proteomics supported by P41 GM108569, United States.
   Research support was provided by the National Institute of Diabetes and
   Digestive and Kidney Diseases (NIDDK) (R01DK090625, R01DK100814, and
   1R01DK113011-01A1 to J.B. and 5K01DK105137-03 and 1R03DK116012-01 to
   C.B.P.); the Chicago Biomedical Consortium S-007, United States (to
   J.B.); the National Institute on Aging (NIA) (P01AG011412 to J.B. and
   C.B.); the National Research Service Award (NRSA) (F30DK116481 to
   B.J.W.); the Swedish Research Council (2014-6888 to J.C.); the Swedish
   Society for Medical Research (to J.C.); the National Institute of
   Neurological Disorders and Stroke (NINDS) (R21NS099813 to C.L.); the
   National Heart, Lung, and Blood Institute (NHLBI) (R01HL147545 to C.B.);
   the Roy J. Carver Trust (to C.B.); the NSF-Simons Center for
   Quantitative Biology (Simons Foundation/SFARI 597491-RWC, United States;
   to R.B.); and the National Science Foundation (1764421 to R.B.).
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NR 107
TC 119
Z9 131
U1 3
U2 42
PU CELL PRESS
PI CAMBRIDGE
PA 50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA
SN 1097-2765
EI 1097-4164
J9 MOL CELL
JI Mol. Cell
PD JUN 4
PY 2020
VL 78
IS 5
BP 835
EP +
DI 10.1016/j.molcel.2020.04.010
PG 22
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA LW4MK
UT WOS:000539118200007
PM 32369735
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Bavineni, M
   Wassenaar, TM
   Agnihotri, K
   Ussery, DW
   Lüscher, TF
   Mehta, JL
AF Bavineni, Mahesh
   Wassenaar, Trudy M.
   Agnihotri, Kanishk
   Ussery, David W.
   Luscher, Thomas F.
   Mehta, Jawahar L.
TI Mechanisms linking preterm birth to onset of cardiovascular disease
   later in adulthood
SO EUROPEAN HEART JOURNAL
LA English
DT Review
DE Cardiovascular disease; Prematurity; Microbiome; Inflammation;
   Dyslipidaemia; Renin-angiotensin system
ID CORONARY-HEART-DISEASE; TRIMETHYLAMINE N-OXIDE; INTIMA-MEDIA THICKNESS;
   LONG NONCODING RNA; GESTATIONAL-AGE; ENDOTHELIAL FUNCTION; ARTERIAL
   STIFFNESS; METABOLIC SYNDROME; EARLY GROWTH; RISK-FACTORS
AB Cardiovascular disease (CVD) rates in adulthood are high in premature infants; unfortunately, the underlying mechanisms are not well defined. In this review, we discuss potential pathways that could lead to CVD in premature babies. Studies show intense oxidant stress and inflammation at tissue levels in these neonates. Alterations in lipid profile, foetal epigenomics, and gut microbiota in these infants may also underlie the development of CVD. Recently, probiotic bacteria, such as the mucin-degrading bacterium Akkermansia muciniphila have been shown to reduce inflammation and prevent heart disease in animal models. All this information might enable scientists and clinicians to target pathways to act early to curtail the adverse effects of prematurity on the cardiovascular system. This could lead to primary and secondary prevention of CVD and improve survival among preterm neonates later in adult life.
C1 [Bavineni, Mahesh] Univ Arkansas Med Sci, Div Hosp Med, Little Rock, AR 72205 USA.
   [Wassenaar, Trudy M.] Mol Microbiol & Genom Consultants, Tannenstr 7, D-55576 Zotzenheim, Germany.
   [Wassenaar, Trudy M.; Ussery, David W.] Univ Arkansas Med Sci, Arkansas Ctr Genom Epidemiol & Med, Dept Biomed Informat, Little Rock, AR 72205 USA.
   [Agnihotri, Kanishk; Mehta, Jawahar L.] Univ Arkansas Med Sci, Div Cardiol, Little Rock, AR 72205 USA.
   [Luscher, Thomas F.] Royal Brompton Hosp, London SW3 6NP, England.
   [Luscher, Thomas F.] Harefield Hosp, London SW3 6NP, England.
   [Luscher, Thomas F.] Univ Zurich, Ctr Mol Cardiol, 4th Floor,Wagistr 12, CH-8952 Schlieren, Switzerland.
C3 University of Arkansas System; University of Arkansas Medical Sciences;
   University of Arkansas System; University of Arkansas Medical Sciences;
   University of Arkansas System; University of Arkansas Medical Sciences;
   Royal Brompton Hospital; Royal Brompton & Harefield NHS Foundation
   Trust; Harefield Hospital
RP Mehta, JL (corresponding author), Univ Arkansas Med Sci, Div Cardiol, Little Rock, AR 72205 USA.
EM mehtajl@uams.edu
RI Ussery, David/J-2026-2019; Mehta, jl/AAB-8832-2019; Bavineni,
   Mahesh/HHC-7062-2022
OI Ussery, David/0000-0003-3632-5512; Bavineni, Mahesh/0000-0001-5286-8432
FU NIH/NIGMS [1P20GM121293]
FX This work was supported in part by NIH/NIGMS [1P20GM121293].
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NR 81
TC 65
Z9 69
U1 2
U2 12
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0195-668X
EI 1522-9645
J9 EUR HEART J
JI Eur. Heart J.
PD APR 7
PY 2019
VL 40
IS 14
BP 1107
EP +
DI 10.1093/eurheartj/ehz025
PG 8
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA HU2IV
UT WOS:000465095500007
PM 30753448
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Ramezani, M
   Hatamipour, M
   Sahebkar, A
AF Ramezani, Mahin
   Hatamipour, Mahdi
   Sahebkar, Amirhosein
TI Promising anti-tumor properties of bisdemethoxycurcumin: A naturally
   occurring curcumin analogue
SO JOURNAL OF CELLULAR PHYSIOLOGY
LA English
DT Review
DE bisdemethoxycurcumin; cancer; curcumin; curcuminoids
ID SYSTEMIC OXIDATIVE STRESS; CANCER COLO-205 CELLS; FATTY LIVER-DISEASE;
   QUALITY-OF-LIFE; NF-KAPPA-B; CLINICAL-PRACTICE; SULFUR MUSTARD;
   MESENCHYMAL TRANSITION; PIPERINE COMBINATION; METABOLIC SYNDROME
AB Curcuminoids are turmeric-extracted phytochemicals with documented chemopreventive and anti-tumor activities against several types of malignancies. Curcuminoids can modulate several molecular pathways and cellular targets involved in different stages of tumor initiation, growth, and metastasis. Bisdemethoxycurcumin (BDMC) is a minor constituent (approximately 3%) of curcuminoids that has been shown to be more stable than the other two main curcuminoids, that is, curcumin and demthoxycurcumin. Recent studies have revealed that BDMC has anti-tumor effects exerted through a multimechanistic mode of action involving inhibition of cell proliferation, invasion and migration, metastasis and tumour growth, and induction of apoptotic death in cancer cells. The present review discusses the findings on the anti-tumor effects of BDMC, underlying mechanisms, and the relevance of finding for translational studies in human.
C1 [Ramezani, Mahin; Hatamipour, Mahdi] Mashhad Univ Med Sci, Nanotechnol Res Ctr, Mashhad, Iran.
   [Sahebkar, Amirhosein] Mashhad Univ Med Sci, Biotechnol Res Ctr, Mashhad, Iran.
C3 Mashhad University of Medical Sciences; Mashhad University of Medical
   Sciences
RP Sahebkar, A (corresponding author), Mashhad Univ Med Sci, Sch Med, Dept Med Biotechnol, Mashhad 9177948564, Iran.
EM sahebkara@mums.ac.ir
RI Sahebkar, Amirhossein/B-5124-2018
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NR 101
TC 60
Z9 63
U1 4
U2 54
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0021-9541
EI 1097-4652
J9 J CELL PHYSIOL
JI J. Cell. Physiol.
PD FEB
PY 2018
VL 233
IS 2
BP 880
EP 887
DI 10.1002/jcp.25795
PG 8
WC Cell Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Physiology
GA FL9RB
UT WOS:000414593500016
PM 28075008
DA 2025-06-11
ER

PT J
AU Hardin, JA
   Cobelli, N
   Santambrogio, L
AF Hardin, John A.
   Cobelli, Neil
   Santambrogio, Laura
TI Consequences of metabolic and oxidative modifications of cartilage
   tissue
SO NATURE REVIEWS RHEUMATOLOGY
LA English
DT Review
ID HUMAN ARTICULAR-CARTILAGE; GLYCATION END-PRODUCTS; AGE-RELATED
   ACCUMULATION; T2 RELAXATION-TIME; HIGH-FAT DIET; PROTEIN OXIDATION;
   MAILLARD REACTION; BIOMECHANICAL PROPERTIES; NONENZYMATIC GLYCATION;
   KNEE OSTEOARTHRITIS
AB A hallmark of chronic metabolic diseases, such as diabetes and metabolic syndrome, and oxidative stress, as occurs in chronic inflammatory and degenerative conditions, is the presence of extensive protein post-translational modifications, including glycation, glycoxidation, carbonylation and nitrosylation. These modifications have been detected on structural cartilage proteins in joints and intervertebral discs, where they are known to affect protein folding, induce protein aggregation and, ultimately, generate microanatomical changes in the proteoglycan collagen network that surrounds chondrocytes. Many of these modifications have also been shown to promote oxidative cleavage as well as enzymatically-mediated matrix degradation. Overall, a general picture starts to emerge indicating that biochemical changes in proteins constitute an early event that compromises the anatomical organization and viscoelasticity of cartilage, thereby affecting its ability to sustain pressure and, ultimately, impeding its overall bio-performance.
C1 [Hardin, John A.; Cobelli, Neil; Santambrogio, Laura] Montefiore Med Ctr, Dept Orthoped Surg, Bronx, NY 10467 USA.
   [Santambrogio, Laura] Albert Einstein Coll Med, Dept Pathol, Bronx, NY 10461 USA.
   [Santambrogio, Laura] Albert Einstein Coll Med, Dept Microbiol & Immunol, Bronx, NY 10461 USA.
   [Santambrogio, Laura] Albert Einstein Coll Med, Dept Immunol, Bronx, NY 10461 USA.
C3 Montefiore Medical Center; Albert Einstein College of Medicine;
   Montefiore Medical Center; Albert Einstein College of Medicine; Yeshiva
   University; Yeshiva University; Montefiore Medical Center; Albert
   Einstein College of Medicine; Montefiore Medical Center; Albert Einstein
   College of Medicine; Yeshiva University
RP Santambrogio, L (corresponding author), Albert Einstein Coll Med, Dept Pathol, 1300 Morris Pk Ave, Bronx, NY 10461 USA.
EM laura.santambrogio@einstein.yu.edu
RI Hardin, James/P-4772-2019; Sanchez-Prieto, Ricardo/B-6877-2008
FU NIAID NIH HHS [R01 AI146180, R01 AI137198] Funding Source: Medline; NIA
   NIH HHS [R01 AG045223, P01 AG031782] Funding Source: Medline
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NR 104
TC 48
Z9 56
U1 2
U2 35
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 1759-4790
EI 1759-4804
J9 NAT REV RHEUMATOL
JI Nat. Rev. Rheumatol.
PD SEP
PY 2015
VL 11
IS 9
BP 521
EP 529
DI 10.1038/nrrheum.2015.70
PG 9
WC Rheumatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Rheumatology
GA CR1JN
UT WOS:000361081100005
PM 26034834
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Chen, YL
   Zong, CL
   Guo, YX
   Tian, L
AF Chen, Yuanli
   Zong, Chunlin
   Guo, Yuxuan
   Tian, Lei
TI Hydrogen-rich saline may be an effective and specific novel treatment
   for osteoradionecrosis of the jaw
SO THERAPEUTICS AND CLINICAL RISK MANAGEMENT
LA English
DT Article
DE osteoradionecrosis; hydrogen; reactive oxygen species
ID MOLECULAR-HYDROGEN; WATER; INJURY; ANTIOXIDANT; INHALATION; PREVENTS;
   STRESS; ISCHEMIA/REPERFUSION; RADIOTHERAPY; CONSUMPTION
AB Hydrogen, a therapeutic medical gas, can exert antioxidant activity via selectively reducing cytotoxic reactive oxygen species such as hydroxyl radicals. Hydrogen-rich saline is an alternative form of molecular hydrogen that has been widely used in many studies, including metabolic syndrome, cerebral, hepatic, myocardial ischemia/reperfusion, and liver injuries with obstructive jaundice, with beneficial results. Osteoradionecrosis of the jaw is a serious complication following radiotherapy for head and neck cancers. It has long been known that most radiation-induced symptoms are caused by free radicals generated by radiolysis of H2O, and the hydroxyl radical is the most reactive of these. Reducing the hydroxyl radical can distinctly improve the protection of cells from radiation damage. We hypothesized that hydrogen-rich saline might be an effective and specific method of managing and preventing osteoradionecrosis of the jaw.
C1 Fourth Mil Med Univ, Dept Craniofacial Trauma, Shaanxi Key Lab Stomatol, Xian 710032, Peoples R China.
   Fourth Mil Med Univ, Shaanxi Key Lab Stomatol, Orthognath Surg Lab Mil Stomatol, Sch Stomatol, Xian 710032, Peoples R China.
C3 Air Force Medical University; Air Force Medical University
RP Tian, L (corresponding author), Fourth Mil Med Univ, Sch Stomatol, 145 West Changle Rd, Xian 710032, Peoples R China.
EM tianleison@163.com
FU National Natural Science Foundation of China [81202150/H2201]
FX This work was supported by funds from National Natural Science
   Foundation of China (81202150/H2201).
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NR 49
TC 6
Z9 7
U1 2
U2 13
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
EI 1178-203X
J9 THER CLIN RISK MANAG
JI Therap. Clin. Risk Manag.
PY 2015
VL 11
BP 1581
EP 1585
DI 10.2147/TCRM.S90770
PG 5
WC Health Care Sciences & Services
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Health Care Sciences & Services
GA CU0PL
UT WOS:000363219400001
PM 26508867
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Bascones-Martínez, A
   González-Febles, J
   Sanz-Esporrín, J
AF Bascones-Martinez, Antonio
   Gonzalez-Febles, Jerian
   Sanz-Esporrin, Javier
TI Diabetes and periodontal disease. Review of the literature
SO AMERICAN JOURNAL OF DENTISTRY
LA English
DT Review
ID METABOLIC SYNDROME; OXIDATIVE STRESS; MELLITUS; DEFINITIONS;
   ASSOCIATION; HEALTH; RISK
AB Diabetes mellitus (DM) is a metabolic disease characterized by an increased blood glucose level, while periodontal disease is mainly characterized by the destruction of tooth support tissues. Detailed investigation is warranted to consider these highly prevalent chronic diseases together and analyze their mutual influence. Over the years, various biologically plausible mechanisms have been established for a common inflammatory etiopathogenesis of these diseases. Numerous epidemiological studies have found a high degree of association between DM and periodontal disease, and periodontal disease has even been proposed as a sixth complication of DM. It has also been demonstrated that this relationship is bidirectional, with periodontitis exerting an effect on DM. These findings have diagnostic and therapeutic implications. Thus, the high prevalence of periodontal disease in DM indicates the need to evaluate glucose levels in periodontal patients. Conversely, intervention studies have demonstrated that the treatment of periodontal disease improves the glycemic control of DM patients.
C1 [Bascones-Martinez, Antonio; Gonzalez-Febles, Jerian; Sanz-Esporrin, Javier] Univ Complutense, Sch Dent, E-28040 Madrid, Spain.
C3 Complutense University of Madrid
RP Bascones-Martínez, A (corresponding author), Univ Complutense, Dept Oral Med & Periodontol, E-28040 Madrid, Spain.
EM antbasco@odon.ucm.es
RI bascones -Martinez, Antonio/JJD-9780-2023; Sanz-Esporrin,
   Javier/H-2025-2017
OI Sanz-Esporrin, Javier/0000-0003-0859-3149
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NR 34
TC 76
Z9 85
U1 0
U2 31
PU MOSHER & LINDER, INC
PI WESTON
PA 318 INDIAN TRACE SUITE 500, WESTON, FL 33326 USA
SN 0894-8275
J9 AM J DENT
JI Am. J. Dent.
PD APR
PY 2014
VL 27
IS 2
BP 63
EP 67
PG 5
WC Dentistry, Oral Surgery & Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dentistry, Oral Surgery & Medicine
GA AH5SX
UT WOS:000336192500001
PM 25000662
DA 2025-06-11
ER

PT J
AU He, YX
   Liu, S
   Lin, H
   Ding, F
   Shao, ZW
   Xiong, LM
AF He, Yuxin
   Liu, Sheng
   Lin, Hui
   Ding, Fan
   Shao, Zengwu
   Xiong, Liming
TI Roles of organokines in intervertebral disc homeostasis and degeneration
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Review
DE intervertebral disc homeostasis; intervertebral disc degeneration;
   organokines; organ crosstalk; signaling pathway
ID LOW-BACK-PAIN; NUCLEUS PULPOSUS CELLS; BONE MORPHOGENETIC PROTEIN-2;
   ANNULUS FIBROSUS CELLS; BEHAVIORAL SIGNS; CHONDROCYTE PROLIFERATION; BMP
   RECEPTORS; EXPRESSION; DIFFERENTIATION; SPARC
AB The intervertebral disc is not isolated from other tissues. Recently, abundant research has linked intervertebral disc homeostasis and degeneration to various systemic diseases, including obesity, metabolic syndrome, and diabetes. Organokines are a group of diverse factors named for the tissue of origin, including adipokines, osteokines, myokines, cardiokines, gastrointestinal hormones, and hepatokines. Through endocrine, paracrine, and autocrine mechanisms, organokines modulate energy homeostasis, oxidative stress, and metabolic balance in various tissues to mediate cross-organ communication. These molecules are involved in the regulation of cellular behavior, inflammation, and matrix metabolism under physiological and pathological conditions. In this review, we aimed to summarize the impact of organokines on disc homeostasis and degeneration and the underlying signaling mechanism. We focused on the regulatory mechanisms of organokines to provide a basis for the development of early diagnostic and therapeutic strategies for disc degeneration.
C1 [He, Yuxin; Liu, Sheng; Lin, Hui; Shao, Zengwu; Xiong, Liming] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Orthopaed, Wuhan, Peoples R China.
   [Ding, Fan] JingMen Cent Hosp, Dept Orthopaed, Jingmen, Peoples R China.
   [Ding, Fan] Hubei Minzu Univ, Enshi, Peoples R China.
C3 Huazhong University of Science & Technology; Hubei Minzu University
RP Shao, ZW; Xiong, LM (corresponding author), Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Orthopaed, Wuhan, Peoples R China.; Ding, F (corresponding author), JingMen Cent Hosp, Dept Orthopaed, Jingmen, Peoples R China.; Ding, F (corresponding author), Hubei Minzu Univ, Enshi, Peoples R China.
EM jmyydf@163.com; szwpro@163.com; xiongliming@hust.edu.cn
RI Shao, Z-W/AGN-6158-2022; Liming, Xiong/C-9448-2016
FU National Natural Science Foundation of China [82202765, 82160434];
   National Natural Science Foundation of Hubei Province [2022CFB343]
FX The author(s) declare financial support was received for the research,
   authorship, and/or publication of this article. The current work was
   partially funded by the National Natural Science Foundation of China
   (82202765, 82160434) and the National Natural Science Foundation of
   Hubei Province (2022CFB343).
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NR 170
TC 2
Z9 3
U1 2
U2 10
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD MAR 12
PY 2024
VL 15
AR 1340625
DI 10.3389/fendo.2024.1340625
PG 17
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA LY4Z4
UT WOS:001190372300001
PM 38532900
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Toyoda, A
   Sato, M
   Muto, M
   Goto, T
   Miyaguchi, Y
   Inoue, E
AF Toyoda, Atsushi
   Sato, Mizuho
   Muto, Masaki
   Goto, Tatsuhiko
   Miyaguchi, Yuji
   Inoue, Eiichi
TI Metabolomic analyses of plasma and liver of mice fed with immature
   Citrus tumida peel
SO BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
LA English
DT Article
DE Citrus tumida; peel; functional food; metabolomics
ID OXIDATIVE STRESS; PECTIN; DEHYDROGENASE; ABSORPTION; FLAVONOIDS; EXTRACT
AB In this study, we investigated the effects of dietary supplementation of Citrus tumida hort. ex Tanaka on food intake, body and fat tissue weights, and metabolic profiles of plasma and liver in mice. Supplementation with 5% (w/w) of peels of immature C. tumida (PIC) for 4 weeks significantly suppressed body weight gain and decreased adipose tissue weight in epididymal, perirenal, and subcutaneous fats. Metabolome analyses showed that 2-hydroxyvaleric acid levels were reduced in the blood plasma of mice fed with PIC. PIC supplementation significantly elevated dipeptide (Thr-Asp, Ser-Glu, and Ala-Ala), glucuronic acid, and S-methylglutathione levels, and significantly reduced betaine aldehyde levels in the liver. In conclusion, PIC supplementation affects the metabolism of fatty acids, pectin, glutathione, and choline, showing potential beneficial effects for metabolic syndrome and obesity. PIC may be developed as a functional food and used in the treatment of these diseases.
C1 [Toyoda, Atsushi; Sato, Mizuho; Muto, Masaki; Goto, Tatsuhiko; Miyaguchi, Yuji; Inoue, Eiichi] Ibaraki Univ, Coll Agr, Ami, Ibaraki, Japan.
   [Toyoda, Atsushi; Goto, Tatsuhiko; Miyaguchi, Yuji; Inoue, Eiichi] Ibaraki Univ Cooperat Agr & Med Sci IUCAM, Ami, Ibaraki, Japan.
   [Toyoda, Atsushi; Miyaguchi, Yuji; Inoue, Eiichi] Tokyo Univ Agr & Technol, United Grad Sch Agr Sci, Tokyo, Japan.
   [Goto, Tatsuhiko] Obihiro Univ Agr & Vet Med, Obihiro, Hokkaido 0808555, Japan.
C3 Ibaraki University; Ibaraki University; Tokyo University of Agriculture
   & Technology; Obihiro University of Agriculture & Veterinary Medicine
RP Toyoda, A (corresponding author), Ibaraki Univ, Coll Agr, Ami, Ibaraki, Japan.
EM atsushi.toyoda.0516@vc.ibaraki.ac.jp
RI INOUE, EIICHI/AAF-1058-2020; Goto, Tatsuhiko/AAJ-3498-2020; Toyoda,
   Atsushi/AAA-5885-2020
OI Inoue, Eiichi/0000-0003-2759-0453
FU SIP (The Cabinet Office, Japan)
FX This work was supported by the Prioritised Research (Ibaraki University,
   Japan);SIP (The Cabinet Office, Japan).
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NR 39
TC 6
Z9 6
U1 3
U2 24
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0916-8451
EI 1347-6947
J9 BIOSCI BIOTECH BIOCH
JI Biosci. Biotechnol. Biochem.
PD JUN 2
PY 2020
VL 84
IS 6
BP 1098
EP 1104
DI 10.1080/09168451.2020.1719821
EA FEB 2020
PG 7
WC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
   Chemistry, Applied; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
   Chemistry; Food Science & Technology
GA LK7UH
UT WOS:000512790400001
PM 32019425
OA Green Submitted, Bronze
DA 2025-06-11
ER

PT J
AU Novikova, DS
   Garabadzhiu, AV
   Melino, G
   Barlev, NA
   Tribulovich, VG
AF Novikova, D. S.
   Garabadzhiu, A. V.
   Melino, G.
   Barlev, N. A.
   Tribulovich, V. G.
TI AMP-activated protein kinase: Structure, function, and role in
   pathological processes
SO BIOCHEMISTRY-MOSCOW
LA English
DT Review
DE AMP-activated protein kinase; energy metabolism; metabolic syndrome;
   diabetes type 2; cancer; AMPK activators; AMPK inhibitors
ID TUMOR-SUPPRESSOR KINASE; SKELETAL-MUSCLE CELLS; FATTY-ACID OXIDATION;
   GLUCOSE-UPTAKE; GAMMA-SUBUNITS; ADENOSINE-MONOPHOSPHATE; RAT-LIVER;
   EXPERIMENTAL STROKE; INSULIN-RESISTANCE; HEART-FAILURE
AB Recently, AMP-activated protein kinase (AMPK) has emerged as a key regulator of energy balance at cellular and whole-body levels. Due to the involvement in multiple signaling pathways, AMPK efficiently controls ATP-consuming/ATP-generating processes to maintain energy homeostasis under stress conditions. Loss of the kinase activity or attenuation of its expression leads to a variety of metabolic disorders and increases cancer risk. In this review, we discuss recent findings on the structure of AMPK, its activation mechanisms, as well as the consequences of its targets in regulation of metabolism. Particular attention is given to low-molecular-weight compounds that activate or inhibit AMPK; the perspective of therapeutic use of such modulators in treatment of several common diseases is discussed.
C1 [Novikova, D. S.; Garabadzhiu, A. V.; Melino, G.; Barlev, N. A.; Tribulovich, V. G.] Tech Univ, St Petersburg State Technol Inst, St Petersburg 190013, Russia.
C3 Saint Petersburg State Institute of Technology
RP Novikova, DS (corresponding author), Tech Univ, St Petersburg State Technol Inst, Moskovsky Pr 26, St Petersburg 190013, Russia.
EM dc.novikova@gmail.com
RI Barlev, Nikolai/K-5268-2017; Tribulovich, Vyacheslav/R-9426-2016;
   Novikova, Daria/F-1554-2014
OI Tribulovich, Vyacheslav/0000-0001-7723-4962; Garabadjiu,
   Alexander/0000-0001-9972-8517; Novikova, Daria/0000-0002-5310-4570
FU Russian Foundation for Basic Research [14-03-31592 mol_a]; Government of
   the Russian Federation [11.G34.31.0069]; MRC [MC_U132670600] Funding
   Source: UKRI
FX This work was supported by the Russian Foundation for Basic Research,
   project No. 14-03-31592 mol_a, and by grant No. 11.G34.31.0069 from the
   Government of the Russian Federation.
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NR 167
TC 63
Z9 78
U1 0
U2 62
PU MAIK NAUKA/INTERPERIODICA/SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013-1578 USA
SN 0006-2979
EI 0320-9725
J9 BIOCHEMISTRY-MOSCOW+
JI Biochem.-Moscow
PD FEB
PY 2015
VL 80
IS 2
BP 127
EP 144
DI 10.1134/S0006297915020017
PG 18
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA CB9OF
UT WOS:000349960500001
PM 25756529
DA 2025-06-11
ER

PT J
AU Jeong, SJ
   Yoo, SR
   Kim, OS
   Seo, CS
   Shin, HK
AF Jeong, Soo-Jin
   Yoo, Sae-Rom
   Kim, Ohn-Soon
   Seo, Chang-Seob
   Shin, Hyeun-Kyoo
TI Antioxidant and Antiadipogenic Activities of Galkeun-Tang, a Traditional
   Korean Herbal Formula
SO EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Article
ID INCREASED OXIDATIVE STRESS; KAKKON-TO; METABOLIC SYNDROME;
   GLYCEROPHOSPHATE DEHYDROGENASE; ADIPOSE CONVERSION; 3T3-L1 ADIPOCYTES;
   CHINESE MEDICINE; LIPID DROPLETS; EXTRACT; OBESITY
AB Galkeun-tang (GKT; Galgen-tang in Chinese and Kakkon-to in Japanese), a traditional herbal formula, has been used for treatment of the common cold. Here, we report in vitro antioxidant and antiadipogenic effects of GKT. GKT increased the activities of scavenging 2,2'-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) and 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals. GKT also significantly reduced the malondialdehyde (MDA) generation during low-density lipoprotein (LDL) oxidation and the electrophoretic mobility of oxidized LDL, indicating inhibitory effects of GKT on Cu2+-mediated oxidation of LDL. Regarding antiadipogenic activity, GKT treatment significantly suppressed lipid accumulation, triglyceride production, and glycerol-3-phosphate dehydrogenase (GPDH) activity in differentiated 3T3-L1 adipocytes. Consistent with this, GKT significantly reduced the secretion of leptin, a major adipokine, in differentiated 3T3-L1 adipocytes. Overall, our findings suggest that GKT has the potential for antioxidative and antiadipogenic properties.
C1 [Jeong, Soo-Jin; Yoo, Sae-Rom; Kim, Ohn-Soon; Seo, Chang-Seob; Shin, Hyeun-Kyoo] Korea Inst Oriental Med, Herbal Med Res Div, Herbal Med Formulat Res Grp, Taejon 305811, South Korea.
C3 Korea Institute of Oriental Medicine (KIOM)
RP Shin, HK (corresponding author), Korea Inst Oriental Med, Herbal Med Res Div, Herbal Med Formulat Res Grp, Taejon 305811, South Korea.
EM hkshin@kiom.re.kr
OI Yoo, Sae-Rom/0000-0001-8731-2469
FU Korean Institute of Oriental Medicine [K14030]
FX This work was supported by a Grant from the Korean Institute of Oriental
   Medicine (no. K14030).
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NR 39
TC 4
Z9 4
U1 0
U2 1
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1741-427X
EI 1741-4288
J9 EVID-BASED COMPL ALT
JI Evid.-based Complement Altern. Med.
PY 2014
VL 2014
AR 763494
DI 10.1155/2014/763494
PG 9
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA AX1SH
UT WOS:000346725900001
PM 25574183
OA hybrid, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Tiniakos, DG
   Vos, MB
   Brunt, EM
AF Tiniakos, Dina G.
   Vos, Miriam B.
   Brunt, Elizabeth M.
TI Nonalcoholic Fatty Liver Disease: Pathology and Pathogenesis
SO ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE
SE Annual Review of Pathology-Mechanisms of Disease
LA English
DT Review; Book Chapter
DE hepatic steatosis; liver disease
ID MALLORY-DENK BODIES; NF-KAPPA-B; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   HEPATIC STEATOSIS; ADIPOSE-TISSUE; VISCERAL FAT; TNF-ALPHA; TRIGLYCERIDE
   SYNTHESIS; MOLECULAR-MECHANISMS
AB Nonalcoholic fatty liver disease (NNFLD) is recognized as the leading cause of chronic liver disease in adults and children. NTAFLD encompasses a spectrum of liver injuries ranging from steatosis to steatohepatitis with or without fibrosis. Fibrosis may progress to cirrhosis and complications including hepatocellular carcinoma. Histologic findings represent the complexity of pathophysiology. NNFLD is closely associated with obesity and is most closely linked with insulin resistance; the current Western diet, high in saturated fats and fructose, plays a significant role. There are several mechanisms by which excess triglycerides are acquired and accumulate in hepatocytes. Formation of steatotic droplets maybe disordered in NAFLD. Visceral adipose tissue dysfunction in obesity and insulin resistance results in aberrant cytokine expression; many cytokines have a role in liver injury in NAFLD. Cellular stress and immune reactions, as well as the endocannabinoid system, have been implicated in animal models and in some human studeis.
C1 [Tiniakos, Dina G.] Univ Athens, Lab Histol & Embryol, Sch Med, Athens 11527, Greece.
   [Vos, Miriam B.] Emory Univ, Sch Med, Dept Pediat, Atlanta, GA 30322 USA.
   [Brunt, Elizabeth M.] Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63110 USA.
C3 National & Kapodistrian University of Athens; Athens Medical School;
   Emory University; Washington University (WUSTL)
RP Tiniakos, DG (corresponding author), Univ Athens, Lab Histol & Embryol, Sch Med, Athens 11527, Greece.
EM dtiniak@med.uoa.gr; mvos@emory.edu; ebrunt@wustl.edu
RI Tiniakos, Dina/AAA-5708-2020
FU NIDDK NIH HHS [K23 DK080953] Funding Source: Medline
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PI PALO ALTO
PA 4139 EL CAMINO WAY, PO BOX 10139, PALO ALTO, CA 94303-0139 USA
SN 1553-4006
EI 1553-4014
J9 ANNU REV PATHOL-MECH
JI Annu. Rev. Pathol.-Mech. Dis.
PY 2010
VL 5
BP 145
EP 171
DI 10.1146/annurev-pathol-121808-102132
PG 27
WC Pathology
WE Book Citation Index – Science (BKCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Pathology
GA 562DU
UT WOS:000275030400007
PM 20078219
DA 2025-06-11
ER

PT J
AU Ferrari, CKB
AF Ferrari, Carlos K. B.
TI Functional foods and physical activities in health promotion of aging
   people
SO MATURITAS
LA English
DT Review
DE free radicals and antioxidants; soy; tomato; carotenoids; cataract;
   macular degeneration; fruits; vegetables; osteoporosis; endurance and
   strength exercises; women's health; metabolic syndrome; aging brain;
   cardiovascular diseases; hypertension; cancer
ID BONE-MINERAL DENSITY; BODY-MASS INDEX; CALORIC RESTRICTION; SERUM
   CAROTENOIDS; OXIDATIVE STRESS; ENDOTHELIAL FUNCTION; COGNITIVE FUNCTION;
   BREAST-CANCER; RISK-FACTORS; LIFE-STYLE
AB Foods contain many bioactive compounds that can improve humans' health, helping to decrease the risk of cataract, macular degeneration, cardiovascular and neurological diseases, osteoporosis, and cancer. Regular practice of exercise and physical activity could also help to drive away aging-associated diseases (obesity, osteoporosis, type 2 diabetes, hypertension, Alzheimer's disease, Parkinson's disease, dementia, and stroke). Exercise recommendations to promote both women's and men's health and disease conditions that hinder exercise practice are described. Health promotion practices should focus on both dietary intake of functional foods and regular practice of exercise within the framework of a healthy lifestyle. (c) 2007 Elsevier Ireland Ltd. All rights reserved.
C1 Fac Integrated Bauru, BR-17056100 Bauru, SP, Brazil.
RP Ferrari, CKB (corresponding author), Fac Integrated Bauru, R Rodolfina Dias Domingues Quardra 11, BR-17056100 Bauru, SP, Brazil.
EM ferrariphd@yahoo.com.br
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NR 129
TC 50
Z9 55
U1 0
U2 43
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0378-5122
EI 1873-4111
J9 MATURITAS
JI Maturitas
PD DEC 20
PY 2007
VL 58
IS 4
BP 327
EP 339
DI 10.1016/j.maturitas.2007.09.011
PG 13
WC Geriatrics & Gerontology; Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology; Obstetrics & Gynecology
GA 248QC
UT WOS:000252168300001
PM 17980978
DA 2025-06-11
ER

PT J
AU Reddy, BL
   Reddy, VS
   Saier, MH Jr
AF Reddy, B. Lakshmi
   Reddy, Vamsee S.
   Saier Jr, Milton H.
TI Health Benefits of Intermittent Fasting
SO MICROBIAL PHYSIOLOGY
LA English
DT Review
DE Intermittent fasting; Cancer; Circadian rhythm; Metabolism; Health
ID CORONARY-ARTERY-DISEASE; CALORIC RESTRICTION; WEIGHT-LOSS; ENERGY
   RESTRICTION; OXIDATIVE STRESS; VEGETARIAN DIET; BODY-WEIGHT;
   CARDIOMETABOLIC HEALTH; BETA-HYDROXYBUTYRATE; METABOLIC SYNDROME
AB We propose that intermittent fasting (time-restricted eating), in agreement with the conclusions of other biologists, as revealed in recent publications, promotes the achievement of numerous health benefits including the extension of human and animal lifespans. Background: There is evidence, obtained both with animal model systems and with humans, that intermittent fasting has health benefits. These benefits include extended longevity, weight loss, and counteracting various disease conditions. Such procedures positively influence the benefits of human tissue-specific microbiomes and minimize the consequences of organellar apoptosis. Key Messages: In this review, we attempt to summarize the predominant evidence, published in the scientific literature, relevant to the conclusions that in general, and in many specific instances, intermittent fasting has long-term benefits to animals, including humans, with respect to overall and specific organismal health and longevity. (c) 2024 The Author(s). Published by S. Karger AG, Basel
C1 [Reddy, B. Lakshmi; Reddy, Vamsee S.; Saier Jr, Milton H.] Univ Calif San Diego, Dept Mol Biol, San Diego, CA 92093 USA.
C3 University of California System; University of California San Diego
RP Reddy, BL; Saier, MH Jr (corresponding author), Univ Calif San Diego, Dept Mol Biol, San Diego, CA 92093 USA.
EM lreddy@ucsd.edu; msaier@ucsd.edu
FU US NIH [GM077402]
FX This work was supported in part by US NIH Grant No. # GM077402 and also
   by private funds, both awarded to MHS. Manuscript conception, planning,
   writing, and decision to publish were made collectively by the three
   authors. The funders played no role in the design, data collection, data
   analysis, and reporting of this study.
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NR 157
TC 1
Z9 1
U1 25
U2 40
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 2673-1665
EI 2673-1673
J9 MICROB PHYSIOL
JI Microb. Physiol.
PD JAN-DEC
PY 2024
VL 34
IS 1
BP 142
EP 152
DI 10.1159/000540068
PG 11
WC Biotechnology & Applied Microbiology; Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Microbiology
GA P3J1O
UT WOS:001376905300001
PM 38955141
OA gold
DA 2025-06-11
ER

PT J
AU Li, CY
   Wu, Q
   Li, ZY
   Wang, Z
   Tu, Y
   Chen, C
   Sun, S
   Sun, SR
AF Li, Chenyuan
   Wu, Qi
   Li, Zhiyu
   Wang, Zhong
   Tu, Yi
   Chen, Chuang
   Sun, Si
   Sun, Shengrong
TI Exosomal microRNAs in cancer-related sarcopenia: Tumor-derived exosomal
   microRNAs in muscle atrophy
SO EXPERIMENTAL BIOLOGY AND MEDICINE
LA English
DT Review
DE Exosome; miRNA; cancer-associated sarcopenia; muscle atrophy
ID UBIQUITIN-PROTEASOME PATHWAY; SKELETAL-MUSCLE; BREAST-CANCER;
   MITOCHONDRIAL DYSFUNCTION; OXIDATIVE STRESS; GENE-EXPRESSION; E3 LIGASE;
   CACHEXIA; PROTEIN; ACTIVATION
AB Cancer-associated sarcopenia is a complex metabolic syndrome marked by muscle mass wasting. Muscle wasting is a serious complication that is a primary contributor to cancer-related mortality. The underlying molecular mechanisms of cancer-associated sarcopenia have not been completely described to date. In general, evidence shows that the main pathophysiological alterations in sarcopenia are associated with the degradation of cellular components, an exceptional inflammatory secretome and mitochondrial dysfunction. Importantly, we highlight the prospect that several miRNAs carried by tumor-derived exosomes that have shown the ability to promote inflammatory secretion, activate catabolism, and even participate in the regulation of cellular degradation pathways can be delivered to and exert effects on muscle cells. In this review, we aim to describe the current knowledge about the functions of exosomal miRNAs in the induction of cancer-associated muscle wasting and propose potential treatment strategies.
C1 [Li, Chenyuan; Wu, Qi; Li, Zhiyu; Wang, Zhong; Tu, Yi; Chen, Chuang; Sun, Shengrong] Wuhan Univ, Dept Breast & Thyroid Surg, Renmin Hosp, Wuhan 430060, Peoples R China.
   [Sun, Si] Wuhan Univ, Renmin Hosp, Dept Clin Lab, Wuhan 430060, Peoples R China.
C3 Wuhan University; Wuhan University
RP Sun, SR (corresponding author), Wuhan Univ, Dept Breast & Thyroid Surg, Renmin Hosp, Wuhan 430060, Peoples R China.
EM 59333173@qq.com
RI Chuang, Chen/MVT-7295-2025; wu, qi/HCI-2480-2022
OI wu, qi/0000-0001-6182-5274
FU Health Commission of Hubei Province scientific research project
   [WJ2019Q053]; Guide Foundation of Renmin Hospital of Wuhan University
   [RMYD2018M78]; China Scholarship Council [201806275139]; National
   Natural Science Foundation of China [81903166]; Hubei Province health
   and family planning scientific research project [RMYD2018M78];
   Scientific research project of Hubei provincial health commission
   [WJ2019Q044]; Natural Science Foundation of Hubei [2018CKB916]
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: This work
   was supported by the Health Commission of Hubei Province scientific
   research project (grant No. WJ2019Q053) to Dr Juan Wu; the Guide
   Foundation of Renmin Hospital of Wuhan University (Grant No.
   RMYD2018M78) and the China Scholarship Council for visiting scholar
   support (Grant No. 201806275139) to Dr Shan Zhu; the National Natural
   Science Foundation of China grant (grant No. 81903166), Hubei Province
   health and family planning scientific research project (grant No.
   RMYD2018M78), Scientific research project of Hubei provincial health
   commission (grant No. WJ2019Q044) and the Natural Science Foundation of
   Hubei (grant No. 2018CKB916) to Dr Si Sun.
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NR 124
TC 8
Z9 8
U1 1
U2 11
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1535-3702
EI 1535-3699
J9 EXP BIOL MED
JI Exp. Biol. Med.
PD MAY
PY 2021
VL 246
IS 10
BP 1156
EP 1166
DI 10.1177/1535370221990322
PG 11
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA SF5ZS
UT WOS:000652834000004
PM 33554647
OA Green Published
DA 2025-06-11
ER

PT J
AU Varadaiah, YGC
   Sivanesan, S
   Nayak, SB
   Thirumalarao, KR
AF Varadaiah, Yogaraje Gowda C.
   Sivanesan, Senthilkumar
   Nayak, Shivananda B.
   Thirumalarao, Kashinath R.
TI Purine metabolites can indicate diabetes progression
SO ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
LA English
DT Article
DE Purine metabolites; alloxan; diabetes; xanthine; hypoxanthine
ID URIC-ACID; LIQUID-CHROMATOGRAPHY; OXIDATIVE STRESS; HYPOXANTHINE;
   HYPERTENSION; GLUCOSE; INOSINE; PLASMA; SERUM
AB Serum uric acid is associated with an increased risk of hypertension, cardiovascular disease and chronic kidney disease. Hyperuricemia raises the risk of insulin resistance and metabolic syndrome including diabetes. Aim: To find the association between purine metabolites and diabetic complications in rats. Materials and methods: Alloxan was administered to induce diabetes in rats. After 30 days, the levels of uric acid, inosine, xanthine, hypoxanthine and AMP were assessed in both plasma and liver tissues using HPLC technique. Results: A significant increase in xanthine, hypoxanthine, AMP levels (p < .001 and t-value 2.78) and inosine in plasma and liver tissues (p < .05 and t-value 2.11) with a concomitant increase in uric acid levels (p < .001 and t-value 2.80) was observed in diabetic group. Conclusion: Purine metabolites like uric acid and other intermediate products of purine metabolism are increased in diabetes. These results can be used in addition or separately in evaluating the progression of diabetes.
C1 [Varadaiah, Yogaraje Gowda C.; Sivanesan, Senthilkumar] Saveetha Inst Med & Tech Sci SIMATS, Dept Res & Dev, Chennai, Tamil Nadu, India.
   [Varadaiah, Yogaraje Gowda C.] Bangalore Med Coll & Res Inst, Dept Biochem, Bengaluru 560002, Karnataka, India.
   [Nayak, Shivananda B.] Univ West Indies, Fac Med Sci, Dept Preclin Sci, Trinidad, Trinidad Tobago.
   [Nayak, Shivananda B.; Thirumalarao, Kashinath R.] Subbaiah Inst Med Sci, Dept Biochem, Dept Res & Dev, Shivamogga, India.
C3 Bangalore Medical College & Research Institute (BMCRI); University West
   Indies Mona Jamaica; University West Indies Saint Augustine
RP Varadaiah, YGC (corresponding author), Bangalore Med Coll & Res Inst, Dept Biochem, Bengaluru 560002, Karnataka, India.
EM cvyogaraja@gmail.com
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NR 33
TC 37
Z9 40
U1 0
U2 3
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1381-3455
EI 1744-4160
J9 ARCH PHYSIOL BIOCHEM
JI Arch. Physiol. Biochem.
PD JAN 2
PY 2022
VL 128
IS 1
BP 87
EP 91
DI 10.1080/13813455.2019.1663219
EA SEP 2019
PG 5
WC Biochemistry & Molecular Biology; Biophysics; Endocrinology &
   Metabolism; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Endocrinology &
   Metabolism; Physiology
GA YX0QE
UT WOS:000486513800001
PM 31517540
DA 2025-06-11
ER

PT J
AU Lee, JE
   Park, E
   Lee, JE
   Auh, JH
   Choi, HK
   Lee, J
   Cho, S
   Kim, JH
AF Lee, Ji Eun
   Park, Eunkyo
   Lee, Jung Eun
   Auh, Joong Hyuck
   Choi, Hyung-Kyoon
   Lee, Jaehwi
   Cho, SooMuk
   Kim, Jung-Hyun
TI Effects of a Rubus coreanus Miquel supplement on plasma
   antioxidant capacity in healthy Korean men
SO NUTRITION RESEARCH AND PRACTICE
LA English
DT Article
DE Rubus coreanus Miquel; antioxidant; lipid peroxidation; glutathione
   peroxidase
ID CRANBERRY JUICE CONSUMPTION; E-DEFICIENT MICE; GLUTATHIONE-PEROXIDASE;
   LIPID-PEROXIDATION; METABOLIC SYNDROME; FRUIT INTAKE; CANCER; RATS;
   BLUEBERRY; DISEASE
AB Korean raspberry, Rubus coreanus Miquel (RCM), contains high concentrations of phenolic compounds, which prevent oxidative stress. To determine the effect of RCM on antioxidant capacity in humans, we assessed in vivo lipid oxidation and antioxidant enzyme activities from plasma in 15 healthy men. The subjects ingested 30 g of freeze-dried RCM daily for 4 weeks. Blood was taken at baseline and at the end of the study to determine blood lipid profiles, fasting plasma glucose, liver function, lipid peroxidation, and antioxidant enzyme activities. RCM supplementation had no effect on blood lipid or fasting plasma glucose concentrations but decreased alkaline phosphatase activity. RCM supplementation increased glutathione peroxidase activities (P < 0.05) but had no effect on lipid peroxidation. These results suggest that short-term RCM supplementation may offer health benefits by enhancing antioxidant capacity in a healthy population.
C1 [Lee, Ji Eun; Park, Eunkyo; Lee, Jung Eun; Kim, Jung-Hyun] Chung Ang Univ, Dept Home Econ Educ, Seoul 156756, South Korea.
   [Auh, Joong Hyuck] Chung Ang Univ, Dept Food Sci & Technol, Gyeonggi 456756, South Korea.
   [Choi, Hyung-Kyoon; Lee, Jaehwi] Chung Ang Univ, Coll Pharm, Seoul 156756, South Korea.
   [Cho, SooMuk] Rural Dev Adm, Funct Food & Nutr Div, Gyeonggi 441853, South Korea.
C3 Chung Ang University; Chung Ang University; Chung Ang University; Rural
   Development Administration (RDA), Republic of Korea
RP Kim, JH (corresponding author), Chung Ang Univ, Dept Home Econ Educ, Seoul 156756, South Korea.
EM jjhkim@cau.ac.kr
RI Lee, Jung-Seok/L-6826-2019; LEE, JIEUN/HTN-1777-2023; Auh, Joong
   Hyuck/ABG-9137-2021; Park, Eunkyo/AFW-5411-2022
OI Park, Eunkyo/0000-0002-4023-7198
FU Rural Development Administration [PJ0063872010]
FX This research was financially supported by the Rural Development
   Administration (project number, PJ0063872010), and we sincerely
   appreciate the support.
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NR 48
TC 26
Z9 29
U1 0
U2 4
PU KOREAN NUTRITION SOC
PI SEOUL
PA 804 KST CTR, 635-4 YEOGSAM-SONG KANGNAM-KU, SEOUL, 135-703, SOUTH KOREA
SN 1976-1457
EI 2005-6168
J9 NUTR RES PRACT
JI Nutr. Res. Pract.
PD OCT
PY 2011
VL 5
IS 5
BP 429
EP 434
DI 10.4162/nrp.2011.5.5.429
PG 6
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 843IK
UT WOS:000296665300008
PM 22125680
OA Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Melo, MCA
   Medeiros, FD
   de Bruin, VMS
   Santana, JAP
   Lima, AB
   Daher, ED
AF Aguiar Melo, Matias Carvalho
   Medeiros, Francisco das Chagas
   Sales de Bruin, Veralice Meireles
   Pinheiro Santana, Jose Abraao
   Lima, Alexandre Bastos
   Daher, Elizabeth De Francesco
TI Sleep Quality Among Psychiatry Residents
SO CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE
LA English
DT Article
DE sleep; medical residency; psychiatry; depression; anxiety; social phobia
ID CORTISOL AWAKENING RESPONSE; MEDICAL-STUDENTS; SELF-MEDICATION; HYGIENE;
   WORK; ASSOCIATION; IMPAIRMENT; PHYSICIANS; RISKS
AB Objective: Medical residency programs are traditionally known for long working hours, which can be associated with a poor quality of sleep and daytime sleepiness. However, few studies have focused on this theme. Our objective was to investigate sleep quality, daytime sleepiness, and their relation with anxiety, social phobia, and depressive symptoms.
   Methods: This cross-sectional observational study involved 59 psychiatry residents. The Pittsburgh Sleep Quality Index (PSQI) and the Epworth Sleepiness Scale (ESS) were used to measure the quality of sleep and excessive daytime sleepiness ([EDS] and ESS > 10), respectively.
   Results: Among the 59 psychiatry residents, 59.3% had poor sleep quality (PSQI > 5) and 28.8% had EDS. Poor sleep quality was associated with higher EDS (P = 0.03) and the year of residency program (P = 0.03). Only 20% of residents with poor sleep had consulted at least once for sleep problems; 54.2% had used medications for sleep; and 16.9% were using medications at the time of interview. Only 30% obtained medication during medical consultations. Poor sleep was associated with irregular sleep hours (P = 0.001) and long periods lying down without sleep (P = 0.03). Poor sleep quality was also associated with high scores of anxiety symptoms (P < 0.001) and social phobia symptoms (P = 0.02).
   Conclusion: Psychiatry residents frequently have poor sleep quality and EDS. Considering that sleep disorders can affect quality of life, predispose to metabolic syndrome, and be associated with worse performance at work, attention to this clinical problem is needed.
   Objectif: Les programmes de residence en medecine sont reconnus traditionnellement pour leurs longues heures de travail, qui peuvent etre associees a une mauvaise qualite du sommeil et a une somnolence diurne. Toutefois, peu d'etudes se sont penchees sur ce theme. L'objectif de cette etude etait d'investiguer la qualite du sommeil, la somnolence diurne, et leur relation a l'anxiete, a la phobie sociale, et aux symptomes depressifs.
   Methodes: Cette etude transversale par observation comptait 59 residents en psychiatrie. Le Pittsburgh Sleep Quality Index (PSQI) et l'Epworth Sleepiness Scale (ESS) ont servi a mesurer la qualite du sommeil et la somnolence diurne excessive ([SDE] et ESS > 10), respectivement.
   Resultats: Parmi les 59 residents en psychiatrie, 59,3% avaient une mauvaise qualite du sommeil (MQS > 5) et 28,8% avaient une SDE. La mauvaise qualite du sommeil etait associee a une SDE plus elevee (P = 0,03) et au programme de l'annee de residence (P = 0,03). Parmi les residents qui dormaient mal, seulement 20% avaient consulte au moins une fois pour des problemes de sommeil; 54,2% avaient utilise des medicaments pour dormir; et 16,9% en utilisaient presentement. Seulement 30% ont obtenu des medicaments durant des consultations medicales. Le mauvais sommeil etait associe a des heures de sommeil irregulieres (P = 0,001) et a de longues periodes allonge sans dormir (P = 0,03). La mauvaise qualite du sommeil etait aussi associee a des scores eleves de symptomes d'anxiete (P < 0,001) et de symptomes de phobie sociale (P = 0,02).
   Conclusion: Les residents en psychiatrie ont frequemment une mauvaise qualite du sommeil et une somnolence diurne excessive. Considerant que les troubles du sommeil peuvent influer sur la qualite de vie, predisposer au syndrome metabolique, et etre associes a un moins bon rendement au travail, il faut porter attention a ce probleme clinique.
C1 [Aguiar Melo, Matias Carvalho; Medeiros, Francisco das Chagas; Sales de Bruin, Veralice Meireles; Daher, Elizabeth De Francesco] Univ Fed Ceara, Av Sargento Herminio,880,Quadra A,Bloco 5,Apt 201, Fortaleza, Ceara, Brazil.
   [Pinheiro Santana, Jose Abraao] Publ Hlth Sch Ceara, Fortaleza, Ceara, Brazil.
   [Lima, Alexandre Bastos] Frota Pinto Mental Hlth Hosp Ceara, Fortaleza, Ceara, Brazil.
C3 Universidade Federal do Ceara
RP Melo, MCA (corresponding author), Univ Fed Ceara, Av Sargento Herminio,880,Quadra A,Bloco 5,Apt 201, Fortaleza, Ceara, Brazil.
EM matcarv01@yahoo.com.br
RI Melo, Matias/Z-6094-2019; Daher, Elizabeth/G-2210-2012
OI Daher, Elizabeth/0000-0003-4189-1738
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NR 33
TC 12
Z9 15
U1 0
U2 14
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0706-7437
EI 1497-0015
J9 CAN J PSYCHIAT
JI Can. J. Psychiat.-Rev. Can. Psychiat.
PD JAN
PY 2016
VL 61
IS 1
BP 44
EP 49
DI 10.1177/0706743715620410
PG 6
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA DB7YJ
UT WOS:000368733200006
PM 27582452
OA Green Published
DA 2025-06-11
ER

PT J
AU Shen, T
   Zhao, Q
   Luo, YM
   Wang, T
AF Shen, Tong
   Zhao, Qing
   Luo, Yumin
   Wang, Tao
TI Investigating the Role of Zinc in Atherosclerosis: A Review
SO BIOMOLECULES
LA English
DT Review
DE zinc; atherosclerosis; zinc homeostasis-associated proteins; endothelial
   cells; vascular smooth muscle cell; immune cell; cardiovascular risk
   factors; animal study; human study
ID SMOOTH-MUSCLE-CELLS; NF-KAPPA-B; ARTERIAL-BLOOD PRESSURE; NITRIC-OXIDE
   SYNTHASE; TRACE-ELEMENT STATUS; KRUPPEL-LIKE FACTORS; OXIDATIVE STRESS;
   SERUM ZINC; LIPID-PEROXIDATION; METABOLIC SYNDROME
AB Zinc, an indispensable micronutrient for human health, might play an important role in the development of atherosclerosis. Zinc could be involved in the atherogenic process through interaction with atherogenic cells, such as endothelial cells (ECs), vascular smooth muscle cells (VSMCs), and immune cells. In addition, zinc also exerts important positive or negative functions in various atherosclerosis-related risk factors, including lipid metabolism, glucose metabolism, and blood pressure. Currently, evidence focusing on the relationship between zinc status and atherogenic risk factors has been well established, while the direct interaction between zinc and atherosclerosis has not been fully understood. In this review, we aimed to summarize the association between zinc and atherosclerosis and explore current findings on how zinc and zinc homeostasis-associated proteins act in the atherogenic processes.
C1 [Shen, Tong; Luo, Yumin] Capital Med Univ, Inst Cerebrovasc Dis Res, Dept Neurol, Xuanwu Hosp, 45 Changchun St, Beijing 100053, Peoples R China.
   [Zhao, Qing] Peking Union Med Coll, 9 Dongdansantiao St, Beijing 100730, Peoples R China.
   [Luo, Yumin] Beijing Inst Brain Disorders, 10 Xitoutiao, Beijing, Peoples R China.
   [Wang, Tao] Capital Med Univ, Natl Ctr Neurol Disorders, China Int Neurosci Inst, Dept Neurosurg,Xuanwu Hosp, 45 Changchun St, Beijing 100053, Peoples R China.
C3 Capital Medical University; Chinese Academy of Medical Sciences - Peking
   Union Medical College; Peking Union Medical College; Capital Medical
   University
RP Luo, YM (corresponding author), Capital Med Univ, Inst Cerebrovasc Dis Res, Dept Neurol, Xuanwu Hosp, 45 Changchun St, Beijing 100053, Peoples R China.; Luo, YM (corresponding author), Beijing Inst Brain Disorders, 10 Xitoutiao, Beijing, Peoples R China.; Wang, T (corresponding author), Capital Med Univ, Natl Ctr Neurol Disorders, China Int Neurosci Inst, Dept Neurosurg,Xuanwu Hosp, 45 Changchun St, Beijing 100053, Peoples R China.
EM yumin111@ccmu.edu.cn; wangtao_dr@xwhosp.org
RI Wang, Tao/AAT-3028-2020
OI Luo, Yumin/0000-0002-2712-8974; , Tao/0000-0003-1225-0173
FU National Natural Science Foundation of China [82171303, 82171301];
   Capital Funds for Health Improvement and Research [2020-2-1032]
FX This research was funded by National Natural Science Foundation of
   China, grant number 82171303 & 82171301, and Capital Funds for Health
   Improvement and Research, grant number 2020-2-1032.
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NR 228
TC 17
Z9 18
U1 3
U2 28
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2218-273X
J9 BIOMOLECULES
JI Biomolecules
PD OCT
PY 2022
VL 12
IS 10
AR 1358
DI 10.3390/biom12101358
PG 25
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 5O0OV
UT WOS:000872184100001
PM 36291566
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Nunn, ER
   Shinde, AB
   Zaganjor, E
AF Nunn, Elizabeth R.
   Shinde, Abhijit B.
   Zaganjor, Elma
TI Weighing in on Adipogenesis
SO FRONTIERS IN PHYSIOLOGY
LA English
DT Review
DE epigenetics; mitochondria; metabolism; adipose; adipogenesis
ID ATP-CITRATE LYASE; PPAR-GAMMA; ADIPOCYTE DIFFERENTIATION; SUBCELLULAR
   COMPARTMENTATION; INSULIN SENSITIVITY; OXIDATIVE STRESS; C/EBP-ALPHA;
   METABOLISM; EXPRESSION; PROMOTES
AB Obesity is a growing health concern worldwide because of its contribution to metabolic syndrome, type II diabetes, insulin resistance (IR), and numerous cancers. In obesity, white adipose tissue (WAT) expands through two mechanisms: increase in adipocyte cell number by precursor cell differentiation through the process of adipogenesis (hyperplasia) and increase in existing mature adipocyte cell size (hypertrophy). While hypertrophy is associated with the negative effects of obesity on metabolic health, such as inflammation and lipotoxicity, adipogenesis prevents obesity-mediated metabolic decline. Moreover, in metabolically healthy obesity adipogenesis is increased. Thus, it is vital to understand the mechanistic basis for adipose expansion to inform novel therapeutic approaches to mitigate the dysfunction of this tissue and associated diseases. In this mini-review, we summarize recent studies on the regulation of adipogenesis and provide a perspective on targeting adipogenesis as a potential therapeutic avenue for metabolic disorders.
C1 [Nunn, Elizabeth R.; Shinde, Abhijit B.; Zaganjor, Elma] Vanderbilt Univ, Sch Med, Dept Mol Physiol & Biophys, Nashville, TN 37212 USA.
C3 Vanderbilt University
RP Zaganjor, E (corresponding author), Vanderbilt Univ, Sch Med, Dept Mol Physiol & Biophys, Nashville, TN 37212 USA.
EM elma.zaganjor@vanderbilt.edu
RI Shinde, Abhijit/AEY-9176-2022
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NR 77
TC 14
Z9 15
U1 1
U2 20
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1664-042X
J9 FRONT PHYSIOL
JI Front. Physiol.
PD FEB 25
PY 2022
VL 13
AR 821278
DI 10.3389/fphys.2022.821278
PG 8
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA ZR1TW
UT WOS:000767575500001
PM 35283790
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Salehi, B
   Del Prado-Audelo, ML
   Cortés, H
   Leyva-Gómez, G
   Stojanovic-Radic, Z
   Singh, YD
   Patra, JK
   Das, G
   Martins, N
   Martorell, M
   Sharifi-Rad, M
   Cho, WC
   Sharifi-Rad, J
AF Salehi, Bahare
   Del Prado-Audelo, Maria L.
   Cortes, Hernan
   Leyva-Gomez, Gerardo
   Stojanovic-Radic, Zorica
   Singh, Yengkhom Disco
   Patra, Jayanta Kumar
   Das, Gitishree
   Martins, Natalia
   Martorell, Miquel
   Sharifi-Rad, Marzieh
   Cho, William C.
   Sharifi-Rad, Javad
TI Therapeutic Applications of Curcumin Nanomedicine Formulations in
   Cardiovascular Diseases
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Review
DE curcumin; cardiovascular disease; nanomedicine; nanocurcumin; liposome;
   nanoformulation
ID DOUBLE-BLIND; OXIDATIVE STRESS; CLINICAL-TRIAL; DRUG-DELIVERY; IN-VITRO;
   METABOLIC SYNDROME; NATURAL-PRODUCTS; CHOLESTEROL ACCUMULATION;
   CARDIOMYOCYTE APOPTOSIS; ORAL BIOAVAILABILITY
AB Cardiovascular diseases (CVD) compromises a group of heart and blood vessels disorders with high impact on human health and wellbeing. Curcumin (CUR) have demonstrated beneficial effects on these group of diseases that represent a global burden with a prevalence that continues increasing progressively. Pre- and clinical studies have demonstrated the CUR effects in CVD through its anti-hypercholesterolemic and anti-atherosclerotic effects and its protective properties against cardiac ischemia and reperfusion. However, the CUR therapeutic limitation is its bioavailability. New CUR nanomedicine formulations are developed to solve this problem. The present article aims to discuss different studies and approaches looking into the promising role of nanotechnology-based drug delivery systems to deliver CUR and its derivatives in CVD treatment, with an emphasis on their formulation properties, experimental evidence, bioactivity, as well as challenges and opportunities in developing these systems.
C1 [Salehi, Bahare] Bam Univ Med Sci, Sch Med, Student Res Comm, Bam 44340847, Iran.
   [Del Prado-Audelo, Maria L.; Leyva-Gomez, Gerardo] Univ Nacl Autonoma Mexico, Fac Quim, Dept Farm, Ciudad Univ,Circuito Exterior S-N, Mexico City 04510, DF, Mexico.
   [Del Prado-Audelo, Maria L.] Univ Nacl Autonoma Mexico, FES Cuautitlan, Lab Posgrad Tecnol Farmaceut, Cuautitlan 54740, Izcalli, Mexico.
   [Cortes, Hernan] Inst Nacl Rehabil Luis Guillermo Ibarra Ibarra, Dept Genet, Lab Med Genom, Mexico City 14389, DF, Mexico.
   [Stojanovic-Radic, Zorica] Univ Nis, Fac Sci & Math, Dept Biol & Ecol, Nish 18000, Serbia.
   [Singh, Yengkhom Disco] Cent Agr Univ, Coll Hort & Forestry, Dept Postharvest Technol, Pasighat 791102, Arunachal Prade, India.
   [Patra, Jayanta Kumar; Das, Gitishree] Dongguk Univ Seoul, Res Inst Biotechnol & Med Converged Sci, Goyangsi 10326, South Korea.
   [Martins, Natalia] Univ Porto, Fac Med, P-4200319 Porto, Portugal.
   [Martins, Natalia] Univ Porto, Inst Res & Innovat Hlth i3S, P-4200135 Porto, Portugal.
   [Martorell, Miquel] Univ Concepcion, Fac Pharm, Dept Nutr & Dietet, Concepcion 4070386, Chile.
   [Martorell, Miquel] Univ Concepcion UDT, Unidad Desarrollo Tecnol, Concepcion 4070386, Chile.
   [Sharifi-Rad, Marzieh] Univ Zabol, Agr Res Inst, Res Dept Agron & Plant Breeding, Zabol 3585698613, Iran.
   [Cho, William C.] Queen Elizabeth Hosp, Dept Clin Oncol, 30 Gascoigne Rd, Hong Kong, Peoples R China.
   [Sharifi-Rad, Javad] Shahid Beheshti Univ Med Sci, Phytochem Res Ctr, Tehran 1991953381, Iran.
C3 Universidad Nacional Autonoma de Mexico; Universidad Nacional Autonoma
   de Mexico; University of Nis; Dongguk University; Universidade do Porto;
   Universidade do Porto; i3S - Instituto de Investigacao e Inovacao em
   Saude, Universidade do Porto; Universidad de Concepcion; Shahid Beheshti
   University Medical Sciences
RP Martins, N (corresponding author), Univ Porto, Fac Med, P-4200319 Porto, Portugal.; Martins, N (corresponding author), Univ Porto, Inst Res & Innovat Hlth i3S, P-4200135 Porto, Portugal.; Martorell, M (corresponding author), Univ Concepcion, Fac Pharm, Dept Nutr & Dietet, Concepcion 4070386, Chile.; Martorell, M (corresponding author), Univ Concepcion UDT, Unidad Desarrollo Tecnol, Concepcion 4070386, Chile.; Cho, WC (corresponding author), Queen Elizabeth Hosp, Dept Clin Oncol, 30 Gascoigne Rd, Hong Kong, Peoples R China.; Sharifi-Rad, J (corresponding author), Shahid Beheshti Univ Med Sci, Phytochem Res Ctr, Tehran 1991953381, Iran.
EM bahar.salehi007@gmail.com; luisa.delpradoa@gmail.com;
   hcortes_c@hotmail.com; gerardoleyva@hotmail.com;
   zstojanovicradic@yahoo.com; disco.iitg@gmail.com; jkpatra.cet@gmail.com;
   gitishreedas@gmail.com; ncmartins@med.up.pt; mmartorell@udec.cl;
   marzieh.sharifirad@gmail.com; chocs@ha.org.hk;
   javad.sharifirad@gmail.com
RI Cortes, Hernan/M-6366-2019; Leyva-Gómez, Gerardo/AAO-6530-2020;
   Del+Prado+Audelo, María/AAZ-4754-2021; Cho, William/H-7429-2019; Singh,
   Yengkhom/V-2259-2019; PATRA, JAYANTA KUMAR/AEM-6689-2022; Sharifi-Rad,
   Javad/D-5747-2016; Martorell, Miquel/H-8490-2014; Cruz-Martins,
   Natalia/P-2972-2015; Salehi, Bahare/F-6847-2018; Das,
   Gitishree/ISA-9164-2023
OI PATRA, JAYANTA KUMAR/0000-0003-4118-4355; Cortes,
   Hernan/0000-0002-6147-4109; Leyva-Gomez, Gerardo/0000-0002-7940-1100;
   Sharifi-Rad, Javad/0000-0002-7301-8151; Del Prado Audelo, Maria
   Luisa/0000-0003-4238-2724; Disco Singh, Yengkhom/0000-0002-7580-2345;
   Martorell, Miquel/0000-0003-3183-7623; Cruz-Martins,
   Natalia/0000-0002-5934-5201; Salehi, Bahare/0000-0002-6900-9797; Das,
   Gitishree/0000-0002-5676-0768
FU CONICYT PIA/APOYO CCTE [AFB170007]; Portuguese Foundation for Science
   and Technology (FCT-Portugal) [UID/BIM/04293/2013]; NORTE2020-Programa
   Operacional Regional do Norte [NORTE-01-0145-FEDER-000012]
FX This work was supported by CONICYT PIA/APOYO CCTE AFB170007. N. Martins
   would like to thank the Portuguese Foundation for Science and Technology
   (FCT-Portugal) for the Strategic project ref. UID/BIM/04293/2013 and
   "NORTE2020-Programa Operacional Regional do Norte"
   (NORTE-01-0145-FEDER-000012).
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NR 202
TC 56
Z9 56
U1 1
U2 34
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD MAR
PY 2020
VL 9
IS 3
AR 746
DI 10.3390/jcm9030746
PG 25
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA LF2UT
UT WOS:000527278800135
PM 32164244
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Filippatos, T
   Tsimihodimos, V
   Pappa, E
   Elisaf, M
AF Filippatos, Theodosios
   Tsimihodimos, Vasilios
   Pappa, Eleni
   Elisaf, Moses
TI Pathophysiology of Diabetic Dyslipidaemia
SO CURRENT VASCULAR PHARMACOLOGY
LA English
DT Review
DE Diabetes; dyslipidaemia; atherosclerosis; apolipoprotein; triglycerides;
   high-density lipoprotein
ID LOW-DENSITY-LIPOPROTEIN; CORONARY-HEART-DISEASE; TRIGLYCERIDE-RICH
   LIPOPROTEINS; METABOLIC SYNDROME; APOLIPOPROTEIN-E; LDL-CHOLESTEROL;
   OBESE-PATIENTS; INSULIN-RESISTANCE; PHOSPHOLIPASE A(2); OXIDATIVE STRESS
AB Background: Patients with diabetes usually exhibit diabetic dyslipidaemia.
   Aim: The aim of the review is to present the quantitative and qualitative alterations of lipids and lipoproteins and the associated mechanisms in patients with diabetic dyslipidaemia.
   Results: The main quantitative changes observed in patients with diabetic dyslipidaemia are increased triglycerides and decreased high-density lipoprotein (HDL) cholesterol levels. Qualitative abnormalities mainly include increased small dense low-density lipoprotein (LDL) particles (despite similar serum LDL cholesterol levels as non-diabetic subjects) and alterations in the apolipoprotein content of HDL particles. Alterations in the activities of enzymes involved in lipoprotein metabolism, such as cholesteryl ester transfer protein, and the lipoprotein content of lipid particles, along with their glycation and oxidation, play a role in the pathogenesis of diabetic dyslipidaemia.
   Conclusion: Diabetic dyslipidaemia is associated with quantitative and qualitative alterations of lipids and lipoproteins, which are associated with increased cardiovascular risk.
C1 [Filippatos, Theodosios; Tsimihodimos, Vasilios; Pappa, Eleni; Elisaf, Moses] Univ Ioannina, Sch Med, Dept Internal Med, Ioannina 45110, Greece.
C3 University of Ioannina
RP Elisaf, M (corresponding author), Univ Ioannina, Sch Med, Dept Internal Med, Ioannina 45110, Greece.
EM melisaf54@gmail.com
RI Filippatos, Theodosios/AAS-6762-2020; Tsimihodimos,
   Vasilis/AAN-9888-2021; Filippatos, Theodosios/I-6016-2016
OI Filippatos, Theodosios/0000-0002-1713-0923; Pappa,
   Eleni/0000-0002-6085-8426; Tsimihodimos, Vasilis/0000-0003-1708-3415
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NR 159
TC 35
Z9 39
U1 0
U2 9
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1570-1611
EI 1875-6212
J9 CURR VASC PHARMACOL
JI Current Vascular Pharmacology
PY 2017
VL 15
IS 6
BP 566
EP 575
DI 10.2174/1570161115666170201105425
PG 10
WC Pharmacology & Pharmacy; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Cardiovascular System & Cardiology
GA FI7UN
UT WOS:000412204500007
PM 28155609
DA 2025-06-11
ER

PT J
AU Mirtschink, P
   Krishnan, J
   Grimm, F
   Sarre, A
   Hörl, M
   Kayikci, M
   Fankhauser, N
   Christinat, Y
   Cortijo, C
   Feehan, O
   Vukolic, A
   Sossalla, S
   Stehr, SN
   Ule, J
   Zamboni, N
   Pedrazzini, T
   Krek, W
AF Mirtschink, Peter
   Krishnan, Jaya
   Grimm, Fiona
   Sarre, Alexandre
   Hoerl, Manuel
   Kayikci, Melis
   Fankhauser, Niklaus
   Christinat, Yann
   Cortijo, Cedric
   Feehan, Owen
   Vukolic, Ana
   Sossalla, Samuel
   Stehr, Sebastian N.
   Ule, Jernej
   Zamboni, Nicola
   Pedrazzini, Thierry
   Krek, Wilhelm
TI HIF-driven SF3B1 induces KHK-C to enforce fructolysis and heart
   disease
SO NATURE
LA English
DT Article
ID CARDIAC-HYPERTROPHY; MASS-SPECTROMETRY; MESSENGER-RNA; CELLS; FAILURE;
   PATHWAY; KETOHEXOKINASE; EXPRESSION; MICE; QUANTIFICATION
AB Fructose is a major component of dietary sugar and its overconsumption exacerbates key pathological features of metabolic syndrome. The central fructose-metabolising enzyme is ketohexokinase (KHK), which exists in two isoforms: KHK-A and KHK-C, generated through mutually exclusive alternative splicing of KHK pre-mRNAs. KHK-C displays superior affinity for fructose compared with KHK-A and is produced primarily in the liver, thus restricting fructose metabolism almost exclusively to this organ. Here we show that myocardial hypoxia actuates fructose metabolism in human and mouse models of pathological cardiac hypertrophy through hypoxia-inducible factor 1 alpha (HIF1 alpha) activation of SF3B1 and SF3B1-mediated splice switching of KHK-A to KHK-C. Heart-specific depletion of SF3B1 orgenetic ablation of Khk, but not Khk-A alone, in mice, suppresses pathological stress-induced fructose metabolism, growth and contractile dysfunction, thus defining signalling components and molecular underpinnings of a fructose metabolism regulatory system crucial for pathological growth.
C1 [Mirtschink, Peter; Krishnan, Jaya; Grimm, Fiona; Fankhauser, Niklaus; Christinat, Yann; Cortijo, Cedric; Feehan, Owen; Vukolic, Ana; Krek, Wilhelm] ETH, Inst Mol Hlth Sci, CH-8093 Zurich, Switzerland.
   [Sarre, Alexandre; Pedrazzini, Thierry] Univ Lausanne, Dept Med, CH-1011 Lausanne, Switzerland.
   [Hoerl, Manuel; Zamboni, Nicola] ETH, Inst Mol Syst Biol, CH-8093 Zurich, Switzerland.
   [Kayikci, Melis; Ule, Jernej] MRC Lab Mol Biol, Cambridge CB2 0QH, England.
   [Sossalla, Samuel] Univ Med Gottingen, Klin Kardiol & Pneumol, D-37075 Gottingen, Germany.
   [Sossalla, Samuel] DZHK German Ctr Cardiovasc Res, Partner Site Gottingen, Hamburg, Germany.
   [Stehr, Sebastian N.] Univ Hosp Jena, Dept Anesthesiol & Crit Care Med, D-07747 Jena, Germany.
C3 Swiss Federal Institutes of Technology Domain; ETH Zurich; University of
   Lausanne; Swiss Federal Institutes of Technology Domain; ETH Zurich; MRC
   Laboratory Molecular Biology; University of Gottingen; German Centre for
   Cardiovascular Research; Friedrich Schiller University of Jena
RP Krek, W (corresponding author), ETH, Inst Mol Hlth Sci, CH-8093 Zurich, Switzerland.
EM wilhelm.krek@biol.ethz.ch
RI Sossalla, Samuel/AAF-3611-2020; Sarre, Alexandre/HNB-4369-2023; Zamboni,
   Nicola/K-3042-2012; Ule, Jernej/C-6315-2013
OI Fankhauser, Niklaus/0000-0002-0023-3993; Ule,
   Jernej/0000-0002-2452-4277; Sarre, Alexandre/0009-0008-7374-8278; Grimm,
   Fiona/0000-0001-5249-619X; Christinat, Yann/0000-0002-4977-1362;
   Krishnan, Jaya/0000-0002-5698-7671; Sossalla,
   Samuel/0000-0001-8034-2673; Zamboni, Nicola/0000-0003-1271-1021
FU Sinergia (Swiss National Science Foundation); Swiss Heart Foundation;
   MRC [MC_U105185858, MC_U105185859] Funding Source: UKRI
FX We thank S. Georgiev, T. Simka, S. Xu, C. Bischoff, J. M. Dominguez, W.
   Kovacs and M. Piontek and other members of the Krek laboratory for
   discussions, help and technical assistance. We are grateful to M.
   Stoffel for performing tail vein injections. K. Chien, A. Asipu and R.
   J. Johnson provided mouse lines. This work was supported by grants from
   Sinergia (Swiss National Science Foundation) to W. K., T.P. and J. U.
   and the Swiss Heart Foundation to W. K.
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NR 48
TC 132
Z9 146
U1 3
U2 66
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0028-0836
EI 1476-4687
J9 NATURE
JI Nature
PD JUN 25
PY 2015
VL 522
IS 7557
BP 444
EP +
DI 10.1038/nature14508
PG 22
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA CL2OC
UT WOS:000356782900042
PM 26083752
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Andersen, CJ
   Fernandez, ML
AF Andersen, Catherine J.
   Fernandez, Maria Luz
TI Dietary approaches to improving atheroprotective HDL functions
SO FOOD & FUNCTION
LA English
DT Review
ID HIGH-DENSITY-LIPOPROTEIN; REVERSE CHOLESTEROL TRANSPORT; SERUM
   PARAOXONASE ACTIVITY; POMEGRANATE JUICE CONSUMPTION; ELEVATED OXIDATIVE
   STRESS; CORONARY-ARTERY-DISEASE; APOLIPOPROTEIN-A-I; SHORT-TERM DIET;
   METABOLIC SYNDROME; ANTIINFLAMMATORY PROPERTIES
AB High-density lipoproteins (HDL) are known to protect against cardiovascular disease (CVD). In addition to facilitating reverse cholesterol transport to remove excess lipids from the body - including atherosclerotic plaques - HDL exhibits antioxidant, anti-inflammatory, vasodilatory, and antithrombotic activities. Together, these properties contribute to the overall atheroprotective nature of HDL. However, similar to many other physiological pathways, these HDL parameters are known to become dysregulated in conditions of metabolic disease. Further, research suggests these alternative HDL properties may be regulated independently of blood HDL-cholesterol (HDL-C) levels, and must therefore be considered when designing HDL-targeted therapies. To date, a number of dietary strategies have been investigated to assess the effect of dietary components on functional properties of HDL beyond HDL-C. This review will highlight the bioactive nutrients, functional foods, and dietary programs known to modulate HDL function as a means of reducing CVD.
C1 [Andersen, Catherine J.; Fernandez, Maria Luz] Univ Connecticut, Dept Nutr Sci, Storrs, CT 06269 USA.
C3 University of Connecticut
RP Andersen, CJ (corresponding author), Univ Connecticut, Dept Nutr Sci, 3624 Horsebarn Rd Ext,Unit 4017, Storrs, CT 06269 USA.
EM maria-luz.fernandez@uconn.edu
OI Andersen, Catherine/0000-0001-9774-5030
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NR 106
TC 29
Z9 37
U1 0
U2 12
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PD SEP
PY 2013
VL 4
IS 9
BP 1304
EP 1313
DI 10.1039/c3fo60207a
PG 10
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA 204GP
UT WOS:000323353500002
PM 23921436
DA 2025-06-11
ER

PT J
AU Kappagoda, CT
   Amsterdam, EA
AF Kappagoda, C. Tissa
   Amsterdam, E. A.
TI Assessment of Risk for Developing Coronary Heart Disease in Asymptomatic
   Individuals
SO JOURNAL OF CARDIOPULMONARY REHABILITATION AND PREVENTION
LA English
DT Review
DE carotid ultrasound; coronary calcium score; emerging risk factors;
   Framingham risk score
ID CARDIOVASCULAR-DISEASE; FAMILY-HISTORY; MYOCARDIAL-INFARCTION;
   PHOSPHOLIPASE A(2); RATIONAL APPROACH; PREDICTION; SCORE; EVENTS; WOMEN;
   ATHEROSCLEROSIS
AB The assessment of risk for developing coronary heart disease (CHD) in asymptomatic individuals Continues to be an important challenge for clinicians. We suggest that the Framingham risk score provides a pragmatic basis for assessing global 10-year CHD risk in this population. The Framingham risk score should be supplemented with additional information pertaining to diabetes, metabolic syndrome, family history, and peripheral arterial disease before a final decision is made with respect to individual risk. In terms of additional investigations, it is suggested that measurement of the ankle brachial index and a stress test that focuses on functional capacity be incorporated into the evaluation of asymptomatic Subjects for CHD. The role of emerging risk factors remains unresolved as is the value of attempting to routinely diagnose subclinical disease with measurements Such as the coronary calcium score.
C1 [Kappagoda, C. Tissa; Amsterdam, E. A.] Univ Calif Davis, Div Cardiovasc Med, Davis, CA 95616 USA.
C3 University of California System; University of California Davis
RP Kappagoda, CT (corresponding author), 4860 Y St,Suite 0200, Sacramento, CA 95817 USA.
EM ctkappagoda@ucdavis.edu
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NR 58
TC 6
Z9 8
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1932-7501
EI 1932-751X
J9 J CARDIOPULM REHABIL
JI J. Cardiopulm. Rehabil. Prev.
PD JUL-AUG
PY 2009
VL 29
IS 4
BP 207
EP 219
PG 13
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 479WB
UT WOS:000268691300001
PM 19628986
DA 2025-06-11
ER

PT J
AU Bilic, I
AF Bilic, Ivan
TI Obesity and cancer
SO PERIODICUM BIOLOGORUM
LA English
DT Article
DE obesity; cancer; carcinogenesis; body mass index; body fat; visceral fat
ID BODY-MASS INDEX; PHYSICAL-ACTIVITY; METABOLIC SYNDROME; LIFE-STYLE;
   WEIGHT; WOMEN; RISK; SURVIVAL; INTERVENTION; DIAGNOSIS
AB Epidemiologic evidence associating obesity and cancer accumulated over last two decades pointing to potentially preventable forms of cancer disease. Observational prospective analyses point to breast and colon cancer as most influenced by obesity-linked lifestyle habits. Other tumor-types can comprise to this group as well (endometrium, esophagus, liver, stomach, thyroid, pancreas, and prostate cancer), according to epidemiological data, but with lesser level of certainty. Randomized studies of lifestyle interventions are still scarce in this area of research, despite being urgently needed. Different pathophysiological mechanisms for obesity-cancer link are proposed in literature. Endocrine factors, deregulated signaling cascades, oxidative stress, and chronic inflammation are implicated as obesity-related carcinogenic processes. Considering growing prevalence of obesity, expert recommendations for lifestyle change (healthy nutrition, physical activity) are widely suggested as a main strategy in primary and secondary prevention of adiposity-related cancers.
C1 Univ Hosp Ctr Zagreb, Dept Med Oncol, Zagreb 10000, Croatia.
C3 University of Zagreb; UNIVERSITY ZAGREB HOSPITAL
RP Bilic, I (corresponding author), Univ Hosp Ctr Zagreb, Dept Med Oncol, Kispaticeva 12, Zagreb 10000, Croatia.
EM ibilic@kbc-zagreb.hr
CR Afshar S, 2014, OBES SURG, V24, P1793, DOI 10.1007/s11695-014-1359-y
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NR 34
TC 1
Z9 1
U1 0
U2 10
PU PERIODICUM BIOLOGORUM
PI ZAGREB
PA HRVATSKO PRIRODOSLOVNO DRUSTVO ILICA 16/111, 41000 ZAGREB, CROATIA
SN 0031-5362
J9 PERIOD BIOL
JI Period. Biol.
PD DEC
PY 2014
VL 116
IS 4
BP 355
EP 359
PG 5
WC Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics
GA CG6SF
UT WOS:000353432000005
DA 2025-06-11
ER

PT J
AU Liu, CS
   Carvalho, AF
   Mansur, RB
   McIntyre, RS
AF Liu, Celina S.
   Carvalho, Andre F.
   Mansur, Rodrigo B.
   McIntyre, Roger S.
TI Obesity and Bipolar Disorder: Synergistic Neurotoxic Effects?
SO ADVANCES IN THERAPY
LA English
DT Review
DE Bipolar disorder; Body mass index; Central nervous system; Comorbidity;
   Co-occurrence; Obesity; Psychiatry
ID BODY-MASS INDEX; WHITE-MATTER ABNORMALITIES; COMORBID MEDICAL
   CONDITIONS; METABOLIC SYNDROME; NEUROTROPHIC FACTOR; OXIDATIVE STRESS;
   WEIGHT-GAIN; MICROSTRUCTURAL ABNORMALITIES; MITOCHONDRIAL DYSFUNCTION;
   ENERGY HOMEOSTASIS
AB Bipolar disorder (BD) is a disabling and chronic neuropsychiatric disorder that is typified by a complex illness presentation, episode recurrence and by its frequent association with psychiatric and medical comorbidities. Over the past decade, obesity has emerged as one of many comorbidities generating substantial concern in the BD population due to important prognostic implications. This comprehensive review details the bidirectional relationship between obesity and BD as evidenced by alterations in the structure and function of the central nervous system, in addition to greater depressive recurrence, cognitive dysfunction and risk of suicidality. Drawing on current research results, this article presents several putative mechanisms underlying the synergistic toxic effects and provides a framework for future treatment options for the obesity-BD comorbidity. There is a need for more large-scale prospective studies to investigate the bidirectional relationships between obesity and BD.
C1 [Liu, Celina S.] Univ Toronto, Dept Human Biol, Toronto, ON, Canada.
   [Liu, Celina S.; Mansur, Rodrigo B.; McIntyre, Roger S.] Toronto Western Hosp, Mood Disorders Psychopharmacol Unit, Toronto, ON M5T 2S8, Canada.
   [Carvalho, Andre F.] Univ Fed Ceara, Fac Med, Dept Clin Med, Psychiat Res Grp, Fortaleza, Ceara, Brazil.
   [Mansur, Rodrigo B.; McIntyre, Roger S.] Univ Toronto, Dept Psychiat, Toronto, ON, Canada.
   [McIntyre, Roger S.] Univ Toronto, Dept Pharmacol, Toronto, ON, Canada.
C3 University of Toronto; University of Toronto; University Health Network
   Toronto; Universidade Federal do Ceara; University of Toronto;
   University of Toronto
RP McIntyre, RS (corresponding author), Toronto Western Hosp, Mood Disorders Psychopharmacol Unit, Toronto, ON M5T 2S8, Canada.
EM roger.mcintyre@uhn.ca
RI McIntyre, Roger/AAU-1000-2020; Carvalho, Andre/AEZ-4001-2022; Mansur,
   Rodrigo/N-7131-2019
FU Stanley Medical Research Institute; National Alliance for Research on
   Schizophrenia and Depression (NARSAD); National Institutes of Mental
   Health; Eli Lilly; Janssen-Ortho; Shire; Astra-Zeneca; Pfizer; Lundbeck;
   Forest; Sepracor; BMS
FX Roger S. McIntyre has received research grants from Stanley Medical
   Research Institute, National Alliance for Research on Schizophrenia and
   Depression (NARSAD), National Institutes of Mental Health, Eli Lilly,
   Janssen-Ortho, Shire, Astra-Zeneca, Pfizer, Lundbeck, Forest, Sepracor,
   and BMS; has served on advisory boards for AstraZeneca, Bristol-Myers
   Squibb, Janssen-Ortho, Eli Lilly, Lundbeck, Pfizer, Shire, Merck,
   Sepracor and Otsuka; has served on speakers bureaus for Janssen-Ortho,
   Astra Zeneca, Eli Lilly, Lundbeck, Merck, Pfizer, and Otsuka; and CME
   activities for Astra Zeneca, Bristol-Myers Squibb, Physicians'
   Postgraduate Press, CME Outfitters, Merck, Eli Lilly, Pfizer, Lundbeck
   and Otsuka. Andre F. Carvalho had received speakers' honoraria from
   Abbott, Libbs Farmaceutica, GSK and Lundbeck. Celina S. Liu declares no
   conflict of interest. Rodrigo B. Mansur declares no conflict of
   interest.
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NR 144
TC 38
Z9 38
U1 0
U2 9
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0741-238X
EI 1865-8652
J9 ADV THER
JI Adv. Ther.
PD NOV
PY 2013
VL 30
IS 11
BP 987
EP 1006
DI 10.1007/s12325-013-0067-7
PG 20
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA 264CI
UT WOS:000327854200003
PM 24194362
DA 2025-06-11
ER

PT J
AU Pharr, JR
   Coughenour, CA
   Bungum, TJ
AF Pharr, J. R.
   Coughenour, C. A.
   Bungum, T. J.
TI An assessment of the relationship of physical activity, obesity, and
   chronic diseases/conditions between active/obese and sedentary/normal
   weight American women in a national sample
SO PUBLIC HEALTH
LA English
DT Article
DE Physical activity; Chronic diseases; Obesity; Women's health; United
   States
ID BODY-MASS INDEX; CARDIOVASCULAR-DISEASE MORTALITY; CARDIORESPIRATORY
   FITNESS; ALL-CAUSE; SOCIAL DETERMINANTS; METABOLIC SYNDROME; RISK;
   OVERWEIGHT; HEALTH; DEPRESSION
AB Objective: Obesity and physical inactivity are associated with increased rates of chronic diseases and conditions. However, the 'fit but fat' theory posits that cardiopulmonary fitness (or physical activity) can mitigate risks to health associated with obesity. The purpose of this study was to compare chronic diseases and conditions of highly active/obese women with inactive/normal weight women.
   Study design: This was a cross-sectional study of the 2015 Behavioral Risk Factor Surveillance System data.
   Methods: Weighted descriptive statistics were performed to describe the demographic characteristics of the two groups. We calculated odds ratios and adjusted odds ratios for chronic diseases and conditions comparing highly active/obese women with inactive/normal weight women.
   Results: Highly active/obese women were more likely to report risk factors (hypertension, high cholesterol, and diabetes) for coronary heart disease (CHD) and cardiovascular disease (CVD) than inactive/normal weight women; however, they did not have increased rates of CVD, CHD, or heart attack and had decreased risk for stroke. Highly active/obese women had increased risk for asthma, arthritis, and depression, but not for cancer, kidney disease, or chronic obstructive pulmonary disease.
   Conclusions: Highly active/obese women appear to be staving off the actual development of CHD and CVD; however, further research is needed to understand the long-term health benefits of physical activity among obese women. (c) 2017 The Royal Society for Public Health. Published by Elsevier Ltd. All rights reserved.
C1 [Pharr, J. R.; Coughenour, C. A.; Bungum, T. J.] Univ Nevada, Las Vegas Sch Community Hlth Sci, 4505 S,Maryland Pkwy, Las Vegas, NV 89154 USA.
C3 Nevada System of Higher Education (NSHE); University of Nevada Las Vegas
RP Pharr, JR (corresponding author), Univ Nevada, Las Vegas Sch Community Hlth Sci, 4505 S,Maryland Pkwy, Las Vegas, NV 89154 USA.
EM Jennifer.pharr@unlv.edu
RI Pharr, Jennifer/AAZ-1368-2020; Coughenour, Courtney/AAZ-7892-2021
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NR 46
TC 18
Z9 22
U1 1
U2 16
PU W B SAUNDERS CO LTD
PI LONDON
PA 32 JAMESTOWN RD, LONDON NW1 7BY, ENGLAND
SN 0033-3506
EI 1476-5616
J9 PUBLIC HEALTH
JI Public Health
PD MAR
PY 2018
VL 156
BP 117
EP 123
DI 10.1016/j.puhe.2017.12.013
PG 7
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA GA0OU
UT WOS:000428014800016
PM 29427767
DA 2025-06-11
ER

PT J
AU Romay, MC
   Toro, C
   Iruela-Arispe, ML
AF Romay, Milagros C.
   Toro, Camilo
   Iruela-Arispe, M. Luisa
TI Emerging molecular mechanisms of vascular dementia
SO CURRENT OPINION IN HEMATOLOGY
LA English
DT Review
DE cerebrovascular disease; cognitive impairment; neuronal degeneration;
   small vessel disease; vascular dementia
ID AUTOSOMAL-DOMINANT ARTERIOPATHY; INDUCED OXIDATIVE STRESS; GENOME-WIDE
   ASSOCIATION; SMALL VESSEL DISEASE; SUBCORTICAL INFARCTS;
   ALZHEIMERS-DISEASE; NADPH OXIDASE; ISCHEMIC-STROKE; LEUKOENCEPHALOPATHY
   CADASIL; MULTIPLE-SCLEROSIS
AB Purpose of review
   Microvascular ischemic disease of the brain is a common cause of cognitive impairment and dementia, particularly in the context of preexisting cardiovascular risk factors and aging. This review summarizes our current understanding of the emerging molecular themes that underlie progressive and irreparable vascular disease leading to neuronal tissue injury and dementia.
   Recent findings
   Cardiometabolic risk factors including diabetes and hypertension are known to contribute to vascular disease. Currently, the impact of these risk factors on the integrity and function of the brain vasculature has been target of intense investigation. Molecularly, the consequences associated with these risk factors indicate that reactive oxygen species are strong contributors to cerebrovascular dysfunction and injury. In addition, genetic linkage analyses have identified penetrant monogenic causes of vascular dementia. Finally, recent reports begun to uncover a large number of polymorphisms associated with a higher risk for cerebrovascular disease.
   Summary
   A comprehensive picture of key risk factors and genetic predispositions that contribute to brain microvascular disease and result in vascular dementia is starting to emerge. Understanding their relationships and cross-interactions will significantly aid in the development of preventive and intervention strategies for this devastating condition.
C1 [Romay, Milagros C.; Iruela-Arispe, M. Luisa] Univ Calif Los Angeles, Dept Mol Cell & Dev Biol, Los Angeles, CA USA.
   [Toro, Camilo] NIH, Undiagnosed Dis Program, Bldg 10, Bethesda, MD 20892 USA.
   [Iruela-Arispe, M. Luisa] Univ Calif Los Angeles, Mol Biol Inst, Los Angeles, CA USA.
C3 University of California System; University of California Los Angeles;
   National Institutes of Health (NIH) - USA; University of California
   System; University of California Los Angeles
RP Iruela-Arispe, ML (corresponding author), UCLA, Box 951606,621 Charles E Young Dr South, Los Angeles, CA 90095 USA.
EM arispe@mcdb.ucla.edu
RI Iruela-Arispe, M./AAJ-1297-2020
OI Iruela-Arispe, Luisa/0000-0002-3050-4168; Romay,
   Milagros/0000-0003-3593-0462
FU National Health Institute [U01HL31019]; National Heart Lung and Blood
   Institute [T32HL069766] Funding Source: NIH RePORTER
FX This work was supported by a grant from the National Health Institute
   U01HL31019.
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U1 0
U2 13
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1065-6251
EI 1531-7048
J9 CURR OPIN HEMATOL
JI Curr. Opin. Hematol.
PD MAY
PY 2019
VL 26
IS 3
BP 199
EP 206
DI 10.1097/MOH.0000000000000502
PG 8
WC Hematology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Hematology
GA HX9UK
UT WOS:000467753800012
PM 30883434
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Hao, MH
   Zhang, CG
   Wang, T
   Hu, H
AF Hao, Minghui
   Zhang, Chungang
   Wang, Ti
   Hu, Heng
TI Pharmacological effects, formulations, and clinical research progress of
   curcumin
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Review
DE curcumin; formulation; pharmacological effect; clinical research; review
ID EPITHELIAL-MESENCHYMAL TRANSITION; SOLID DISPERSION; IN-VITRO; ENHANCED
   BIOAVAILABILITY; RELEASE CHARACTERISTICS; ANTITUMOR-ACTIVITY; OXIDATIVE
   STRESS; INHIBITION; CHITOSAN; DISEASE
AB Curcumin, a polyphenolic compound derived from the traditional Chinese medicine turmeric, which has a variety of pharmacological effects, including anti-cancer, anti-inflammatory, antioxidant, and antiviral properties. However, its clinical application is hindered by low solubility and bioavailability. To overcome these limitations, researchers have developed various formulations such as nanoformulations, solid dispersions, and microspheres. These advancements have led to improved therapeutic effects and have facilitated the progression of clinical research, primarily focusing on Phase I and Phase II trials for conditions like diabetes, obesity, and metabolic syndrome. In recent years, there has been a noticeable increase in Phase III and IV clinical trials, particularly concerning oral and dental diseases and arthritis. This article reviews recent literature from both domestic and international sources, providing a comprehensive overview of curcumin's research progress, including its pharmacological mechanisms, formulation developments, and clinical studies.
C1 [Hao, Minghui; Zhang, Chungang; Wang, Ti; Hu, Heng] Liaoning Univ Tradit Chinese Med, Coll Pharm, Dalian, Peoples R China.
   [Zhang, Chungang] Changzhi Med Coll, Dept Pharm, Changzhi, Peoples R China.
   [Zhang, Chungang] Qimeng Co LTD, Chifeng, Peoples R China.
C3 Liaoning University of Traditional Chinese Medicine; Changzhi Medical
   College
RP Zhang, CG (corresponding author), Liaoning Univ Tradit Chinese Med, Coll Pharm, Dalian, Peoples R China.; Zhang, CG (corresponding author), Changzhi Med Coll, Dept Pharm, Changzhi, Peoples R China.; Zhang, CG (corresponding author), Qimeng Co LTD, Chifeng, Peoples R China.
EM zhangchungangpharm@outlook.com
RI hao, minghui/GRE-9215-2022
FU National Natural Science Foundation of China [81503257]; Inner Mongolia
   Major science and technology project [2021ZD0017]; Liaoning Provincial
   Science and Technology Programme Joint Programme (Applied Basic Research
   Project) [2023JH2/101700206]; Liaoning University of Traditional Chinese
   Medicine-Natural Science University Key Project [2021LZY047]; Liaoning
   Provincial Department of Education university basic scientific research
   project reserve project [LJ212410162055]; National Key Research and
   Development Program [2018YFC1706903]
FX The author(s) declare that financial support was received for the
   research and/or publication of this article. The National Natural
   Science Foundation of China (No. 81503257); Inner Mongolia Major science
   and technology project (No. 2021ZD0017); Liaoning Provincial Science and
   Technology Programme Joint Programme (Applied Basic Research Project)
   (2023JH2/101700206); Liaoning University of Traditional Chinese
   Medicine-Natural Science University Key Project (2021LZY047); Liaoning
   Provincial Department of Education university basic scientific research
   project reserve project (LJ212410162055); National Key Research and
   Development Program (No. 2018YFC1706903).
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NR 181
TC 0
Z9 0
U1 6
U2 6
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD MAR 17
PY 2025
VL 16
AR 1509045
DI 10.3389/fphar.2025.1509045
PG 25
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 0SN9C
UT WOS:001454995600001
PM 40166470
OA gold
DA 2025-06-11
ER

PT J
AU da Cruz, BO
   Cardozo, LFMD
   Magliano, DC
   Stockler-Pinto, MB
AF da Cruz, Beatriz O.
   de Franca Cardozo, Ludmila F. M.
   Magliano, D'Angelo C.
   Stockler-Pinto, Milena B.
TI Nutritional strategies to modulate inflammation pathways via regulation
   of peroxisome proliferator-activated receptor β/δ
SO NUTRITION REVIEWS
LA English
DT Review
DE inflammation; nutrients; PPAR beta; PPAR delta
ID NITRIC-OXIDE SYNTHASE; PPAR-BETA/DELTA; RETINOIC ACID; TRANSCRIPTIONAL
   COACTIVATOR; MITOCHONDRIAL BIOGENESIS; INSULIN-RESISTANCE; METABOLIC
   SYNDROME; OXIDATIVE STRESS; SKELETAL-MUSCLE; GENE-EXPRESSION
AB The peroxisome proliferator-activated receptor (PPAR) beta/delta has an important role in multiple inflammatory conditions, including obesity, hypertension, cancer, cardiovascular disease, diabetes mellitus, and autoimmune diseases. PPAR beta/delta forms a heterodimer with the retinoic acid receptor and binds to peroxisome proliferator response elements to initiate transcription of its target genes. PPAR beta/delta is also able to suppress the activities of several transcription factors, including nuclear factor kappa B, and activator protein 1, thus regulating anti-inflammatory cellular responses and playing a protective role in several diseases. Recent studies have shown that nutritional compounds, including nutrients and bioactive compounds, can regulate PPAR beta/delta expression. This review discusses key nutritional compounds that are known to modulate PPAR beta/delta and are likely to affect human health.
C1 [da Cruz, Beatriz O.; de Franca Cardozo, Ludmila F. M.; Magliano, D'Angelo C.; Stockler-Pinto, Milena B.] Fluminense Fed Univ UFF, Grad Program Cardiovasc Sci, Niteroi, RJ, Brazil.
   [Magliano, D'Angelo C.] Fluminense Fed Univ UFF, Lab Morphol & Metab Anal, Niteroi, RJ, Brazil.
   [Stockler-Pinto, Milena B.] Fluminense Fed Univ UFF, Grad Program Nutr Sci, Niteroi, RJ, Brazil.
C3 Universidade Federal Fluminense; Universidade Federal Fluminense;
   Universidade Federal Fluminense
RP da Cruz, BO (corresponding author), Hosp Univ Antonio Pedro, Fac Med, Programa Posgrad Ciencias Cardiovasc, Ave Marques Parana,303,4 Andar Predio Anexo, BR-24030215 Niteroi, RJ, Brazil.
EM beatrizoliveira@id.uff.br
RI Cardozo, Ludmila/U-4502-2019; Oliveira da Cruz, Beatriz/NBW-8636-2025;
   Magliano, D'Angelo/U-7364-2019; Stockler-Pinto, Milena/AAJ-1430-2021
OI Magliano, D'Angelo/0000-0002-0575-961X
FU Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
   [001]; Fundacao de Amparo a Pesquisa do Estado do Rio de Janeiro
   (FAPERJ) [E-26/203.269/2017]; Conselho Nacional de Desenvolvimento
   Cientifico e Tecnologico (CNPq)
FX This study was supported by Coordenacao de Aperfeicoamento de Pessoal de
   Nivel Superior (CAPES)-Finance Code 001, Fundacao de Amparo a Pesquisa
   do Estado do Rio de Janeiro (FAPERJ) (Process E-26/203.269/2017), and
   Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq).
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NR 74
TC 8
Z9 8
U1 2
U2 18
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0029-6643
EI 1753-4887
J9 NUTR REV
JI Nutr. Rev.
PD MAR
PY 2020
VL 78
IS 3
BP 207
EP 214
DI 10.1093/nutrit/nuz058
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA KS8JC
UT WOS:000518551900002
PM 31584650
OA Bronze
DA 2025-06-11
ER

PT J
AU Vasu, S
   Kumano, K
   Darden, CM
   Rahman, I
   Lawrence, MC
   Naziruddin, B
AF Vasu, Srividya
   Kumano, Kenjiro
   Darden, Carly M.
   Rahman, Irum
   Lawrence, Michael C.
   Naziruddin, Bashoo
TI MicroRNA Signatures as Future Biomarkers for Diagnosis of Diabetes
   States
SO CELLS
LA English
DT Review
DE diabetes; biomarker; miRNA; islet
ID BETA-CELL DEATH; METABOLIC SYNDROME; CIRCULATING MICRORNAS; POTENTIAL
   BIOMARKER; MIRNA EXPRESSION; RISK; MELLITUS; PREDICT; PLASMA; DNA
AB Diabetes results from the inability of pancreatic islets to maintain blood glucose concentrations within a normal physiological range. Clinical features are usually not observed until islets begin to fail and irreversible damage has occurred. Diabetes is generally diagnosed based on elevated glucose, which does not distinguish between type 1 and 2 diabetes. Thus, new diagnostic approaches are needed to detect different modes of diabetes before manifestation of disease. During prediabetes (pre-DM), islets undergo stress and release micro (mi) RNAs. Here, we review studies that have measured and tracked miRNAs in the blood for those with recent-onset or longstanding type 1 diabetes, obesity, pre-diabetes, type 2 diabetes, and gestational diabetes. We summarize the findings on miRNA signatures with the potential to stage progression of different modes of diabetes. Advances in identifying selective biomarker signatures may aid in early detection and classification of diabetic conditions and treatments to prevent and reverse diabetes.
C1 [Vasu, Srividya; Kumano, Kenjiro; Darden, Carly M.; Rahman, Irum; Lawrence, Michael C.] Baylor Scott & White Res Inst, Islet Cell Lab, 3434 Live Oak St, Dallas, TX 75204 USA.
   [Darden, Carly M.] Baylor Univ, Dept Biomed Studies, 1301 S Univ Pk Dr, Waco, TX 75706 USA.
   [Naziruddin, Bashoo] Baylor Univ, Annette C & Harold C Simmons Transplant Inst, Med Ctr, 3410 Worth St,Suite 950, Dallas, TX 75246 USA.
C3 Baylor Health Care System; Baylor University Medical Center; Baylor
   University; Baylor University Medical Center; Baylor University
RP Naziruddin, B (corresponding author), Baylor Univ, Annette C & Harold C Simmons Transplant Inst, Med Ctr, 3410 Worth St,Suite 950, Dallas, TX 75246 USA.
EM srividya.vasu@bswhealth.org; kenjiro.kumano@bswhealth.org;
   Carly.Darden@bswhealth.org; irumrahman97@gmail.com;
   michael.lawrence@bswhealth.org; Bashoo.Naziruddin@BSWHealth.org
OI Vasu, Srividya/0000-0002-6625-9184; Kumano, Kenjiro/0000-0001-5979-7454
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NR 109
TC 126
Z9 132
U1 3
U2 37
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2073-4409
J9 CELLS-BASEL
JI Cells
PD DEC
PY 2019
VL 8
IS 12
AR 1533
DI 10.3390/cells8121533
PG 32
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA KB7AN
UT WOS:000506643500061
PM 31795194
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Oluwaseun, OA
   Khalil, HS
AF Oluwaseun, Omoboye Adebola
   Khalil, Hilal S.
TI WAR WITHOUT WEAPONS - CONSTITUTION OF HEALTHY AND PATHOLOGICAL
   PHENOTYPES ASSOCIATED WITH POLYMORPHISMS IN GENES INVOLVED IN THE
   MAINTENANCE OF GENOME INTEGRITY
SO BIOTECHNOLOGY & BIOTECHNOLOGICAL EQUIPMENT
LA English
DT Review
DE capacity for DNA repair; DNA polymorphisms; P53; HMGA1
ID DNA-REPAIR GENES; PLATINUM-BASED CHEMOTHERAPY; XERODERMA-PIGMENTOSUM;
   METABOLIC SYNDROME; SKIN-CANCER; CODON-72 POLYMORPHISM;
   COLORECTAL-CANCER; OXIDATIVE STRESS; P53; TP53
AB Capacity to repair DNA damage may vary significantly between individuals coining out as healthy on routine physical and laboratory examinations. This variance does not generally cause distress or disease unless in case that specific triggers are prevent, but, taken together with other factors, may increase the risk for certain types of cancer or may modulate the outcome of anticancer therapies. Carriership of certain polymorphic variants in DNA repair genes may also modify the course of the normal process of aging. The present paper reviews the role of some of the common polymorphisms in DNA repair genes and in genes involved in the maintenance of genomic integrity; and their association, separately or in combination, with the 'healthy' phenotype and with certain diseases and conditions related to exposure to increased levels of oxidative damage.
C1 [Oluwaseun, Omoboye Adebola; Khalil, Hilal S.] Univ Abertay Dundee, Sch Contemporary Sci, Dundee, Scotland.
C3 University of Abertay Dundee
RP Khalil, HS (corresponding author), Univ Abertay Dundee, Sch Contemporary Sci, Dundee, Scotland.
EM H.Khalil@abertay.ac.uk
FU Northwood charitable trust
FX The authors would like to thank Northwood charitable trust for their
   financial support.
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NR 73
TC 0
Z9 0
U1 0
U2 7
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1310-2818
EI 1314-3530
J9 BIOTECHNOL BIOTEC EQ
JI Biotechnol. Biotechnol. Equip.
PD AUG
PY 2012
VL 26
IS 4
BP 3073
EP 3078
DI 10.5504/BBEQ.2012.0053
PG 6
WC Biotechnology & Applied Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology
GA 992TW
UT WOS:000307803600001
OA Green Published
DA 2025-06-11
ER

PT J
AU Yuan, JP
   Peng, JA
   Yin, K
   Wang, JH
AF Yuan, Jian-Ping
   Peng, Juan
   Yin, Kai
   Wang, Jiang-Hai
TI Potential health-promoting effects of astaxanthin: A high-value
   carotenoid mostly from microalgae
SO MOLECULAR NUTRITION & FOOD RESEARCH
LA English
DT Review
DE Astaxanthin; Carotenoid; Haematococcus pluvialis; Health-promoting
   effects; Microalgae
ID XANTHOPHYLLOMYCES-DENDRORHOUS MUTANT; HELICOBACTER-PYLORI INFECTION;
   GASTRIC-MUCOSAL INJURY; OXIDATIVE STRESS; IN-VITRO;
   HAEMATOCOCCUS-PLUVIALIS; TRANS-ASTAXANTHIN; ANTIOXIDANT ASTAXANTHIN;
   SECONDARY CAROTENOIDS; DIETARY CAROTENOIDS
AB The ketocarotenoid astaxanthin can be found in the microalgae Haematococcus pluvialis, Chlorella zofingiensis, and Chlorococcum sp., and the red yeast Phaffia rhodozyma. The microalga H. pluvialis has the highest capacity to accumulate astaxanthin up to 4-5% of cell dry weight. Astaxanthin has been attributed with extraordinary potential for protecting the organism against a wide range of diseases, and has considerable potential and promising applications in human health. Numerous studies have shown that astaxanthin has potential health-promoting effects in the prevention and treatment of various diseases, such as cancers, chronic inflammatory diseases, metabolic syndrome, diabetes, diabetic nephropathy, cardiovascular diseases, gastrointestinal diseases, liver diseases, neurodegenerative diseases, eye diseases, skin diseases, exercise-induced fatigue, male infertility, and HgCl2-induced acute renal failure. In this article, the currently available scientific literature regarding the most significant activities of astaxanthin is reviewed.
C1 [Yuan, Jian-Ping; Peng, Juan; Wang, Jiang-Hai] Sun Yat Sen Univ, Guangdong Prov Key Lab Marine Resources & Coastal, Sch Marine Sci, Guangzhou 510275, Guangdong, Peoples R China.
   [Yin, Kai] Sun Yat Sen Univ, Sch Life Sci, Guangzhou 510275, Guangdong, Peoples R China.
C3 Sun Yat Sen University; Guangdong Provincial Key Laboratory of Marine
   Resources & Coastal Engineering; Sun Yat Sen University
RP Yuan, JP (corresponding author), Sun Yat Sen Univ, Guangdong Prov Key Lab Marine Resources & Coastal, Sch Marine Sci, Guangzhou 510275, Guangdong, Peoples R China.
EM yuanjp@mail.sysu.edu.cn; wangjhai@mail.sysu.edu.cn
RI yin, kai/KHE-2284-2024; Yuan, Jian-Ping/M-2920-2016
FU Science and Technology Planning Project of Guangdong Province, China
   [2007B020708003]
FX This work is supported by Science and Technology Planning Project of
   Guangdong Province, China (2007B020708003).
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NR 128
TC 440
Z9 481
U1 13
U2 450
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1613-4125
EI 1613-4133
J9 MOL NUTR FOOD RES
JI Mol. Nutr. Food Res.
PD JAN
PY 2011
VL 55
IS 1
BP 150
EP 165
DI 10.1002/mnfr.201000414
PG 16
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA 703KY
UT WOS:000285978000012
PM 21207519
DA 2025-06-11
ER

PT J
AU Basu, A
   Rhone, M
   Lyons, TJ
AF Basu, Arpita
   Rhone, Michael
   Lyons, Timothy J.
TI Berries: emerging impact on cardiovascular health
SO NUTRITION REVIEWS
LA English
DT Review
DE anthocyanins; berries; inflammation; lipid peroxidation; nitric oxide
ID CRANBERRY JUICE CONSUMPTION; C-REACTIVE PROTEIN; HDL-CHOLESTEROL
   CONCENTRATIONS; PLASMA ANTIOXIDANT CAPACITY; LOW-DENSITY-LIPOPROTEIN;
   NITRIC-OXIDE SYNTHASE; VEGETABLE INTAKE; IN-VIVO; LIPID-PEROXIDATION;
   METABOLIC SYNDROME
AB Berries are a good source of polyphenols, especially anthocyanins, micronutrients, and fiber. In epidemiological and clinical studies, these constituents have been associated with improved cardiovascular risk profiles. Human intervention studies using chokeberries, cranberries, blueberries, and strawberries (either fresh, or as juice, or freeze-dried), or purified anthocyanin extracts have demonstrated significant improvements in LDL oxidation, lipid peroxidation, total plasma antioxidant capacity, dyslipidemia, and glucose metabolism. Benefits were seen in healthy subjects and in those with existing metabolic risk factors. Underlying mechanisms for these beneficial effects are believed to include upregulation of endothelial nitric oxide synthase, decreased activities of carbohydrate digestive enzymes, decreased oxidative stress, and inhibition of inflammatory gene expression and foam cell formation. Though limited, these data support the recommendation of berries as an essential fruit group in a heart-healthy diet. (C) 2010 International Life Sciences Institute
C1 [Basu, Arpita; Rhone, Michael] Oklahoma State Univ, Dept Nutrit Sci, Stillwater, OK 74078 USA.
   [Lyons, Timothy J.] Univ Oklahoma, Harold Hamm Oklahoma Diabet Ctr, Hlth Sci Ctr, Oklahoma City, OK USA.
C3 Oklahoma State University System; Oklahoma State University -
   Stillwater; University of Oklahoma System; University of Oklahoma Health
   Sciences Center
RP Basu, A (corresponding author), Oklahoma State Univ, Dept Nutrit Sci, Human Environm Sci 301, Stillwater, OK 74078 USA.
EM arpita.basu@okstate.edu
OI Lyons, Timothy/0000-0003-2106-1622
FU University of Oklahoma Health Sciences Center General Clinical Research
   Center [M01-RR14467]; National Center for Research Resources, and the
   National Institutes of Health
FX Funding. This work was supported, in part, by the University of Oklahoma
   Health Sciences Center General Clinical Research Center grant
   M01-RR14467, the National Center for Research Resources, and the
   National Institutes of Health.
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NR 72
TC 326
Z9 389
U1 3
U2 171
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0029-6643
EI 1753-4887
J9 NUTR REV
JI Nutr. Rev.
PD MAR
PY 2010
VL 68
IS 3
BP 168
EP 177
DI 10.1111/j.1753-4887.2010.00273.x
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 560SK
UT WOS:000274922600004
PM 20384847
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Yenice, MG
   Danacioglu, YO
   Mert, M
   Karakaya, P
   Seker, KG
   Akkas, F
   Simsek, A
   Sahin, S
   Tasçi, AI
AF Yenice, Mustafa Gurkan
   Danacioglu, Yavuz Onur
   Mert, Meral
   Karakaya, Pinar
   Seker, Kamil Gokhan
   Akkas, Fatih
   Simsek, Abdulmuttalip
   Sahin, Selcuk
   Tasci, Ali Ihsan
TI Evaluation of factors affecting sexual dysfunction in female patients
   with diabetes mellitus
SO ARCHIVES OF ENDOCRINOLOGY METABOLISM
LA English
DT Article
DE Arylesterase; diabetes mellitus; endocrine disorder; female sexual
   dysfunction; paraoxonase-1
ID METABOLIC SYNDROME; SERUM PARAOXONASE; WOMEN; GENE; DEPRESSION
AB Objective: Our objective in this study was to evaluate the factors predicting female sexual dysfunction (FSD) in patients with diabetes mellitus (DM). Subjects and methods: The study included 149 women with DM. Sexual function was evaluated with the Female Sexual Function Index (FSFI) questionnaire, in which total scores under 26.55 characterized the occurrence of FSD (Group 1 > 26.55, Group 2 < 26.55). We recorded the patients' demographic, metabolic, and hormonal data. Ophthalmologic, neurologic, and renal complications were also evaluated. The antioxidant status of the patients in both groups was determined by measuring the activity of the enzymes paraoxonase-1 (PON-1) and arylesterase (ARE). Results: Based on the FSFI scores, 60 patients were allocated to Group 1 (26.6 +/- 12.3) and 89 to Group 2 (22.6 +/- 9.5). Group 2 compared with Group 1 had significantly (p < 0.05) higher mean concentrations of glycated hemoglobin (HbA1c), glucose, triglycerides, and insulin, along with higher rates of metformin use, smoking, retinopathy, and nephropathy. The mean serum ARE concentrations were significantly lower in Group 2 compared with Group 1 (p = 0.000), but the mean serum PON-1 concentrations were similar between both groups (p = 0.218). On multivariable regression analysis, age, ARE activity, Beck Depression Inventory (BDI) score, and menopause were significant independent predictors of FSD (p < 0.05). Conclusions: In this study, we evaluated the predictive factors determining FSD caused by DM. Despite the significant results found in our study, future randomized controlled studies with a long follow-up and a larger number of patients are required to determine how DM affects FSD.
C1 [Yenice, Mustafa Gurkan; Danacioglu, Yavuz Onur; Seker, Kamil Gokhan; Akkas, Fatih; Simsek, Abdulmuttalip; Sahin, Selcuk; Tasci, Ali Ihsan] Univ Hlth Sci, Clin Urol, Bakirkoy Dr Sadi Konuk Training & Res Hosp, Istanbul, Turkey.
   [Mert, Meral; Karakaya, Pinar] Univ Hlth Sci, Dept Endocrinol, Bakirkoy Dr Sadi Konuk Training & Res Hosp, Istanbul, Turkey.
C3 University of Health Sciences Turkey; Bakirkoy Dr. Sadi Konuk Research &
   Training Hospital; Bakirkoy Dr. Sadi Konuk Research & Training Hospital;
   University of Health Sciences Turkey
RP Danacioglu, YO (corresponding author), Bakirkoy Dr Sadi Konuk Educ & Res Hosp, Dept Urol, Tevfik Saglam Caddesi 11, TR-34147 Istanbul, Turkey.
EM yavuzonurd@gmail.com
RI Mert, Meral/KXR-1439-2024; akkaş, fatih/AAE-5574-2019; Danacioglu,
   Yavuz/AFI-4209-2022; Taşçı, Ali ihsan/JMP-9487-2023; Sahin,
   Selcuk/AEP-0805-2022
OI Tasci, Ali iihsan/0000-0002-6943-6676; Mert, Meral/0000-0003-3431-0915;
   karakaya, pinar/0000-0003-3638-5603; akkas, fatih/0000-0002-4560-7426;
   Danacioglu, Yavuz Onur/0000-0002-3170-062X; Seker, Kamil
   Gokhan/0000-0003-4449-9037
CR Aldemir M, 2012, ANDROLOGIA, V44, P266, DOI 10.1111/j.1439-0272.2011.01174.x
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NR 29
TC 15
Z9 17
U1 0
U2 1
PU SBEM-SOC BRASIL ENDOCRINOLOGIA & METABOLOGIA
PI RIO DE JANEIRO, RJ
PA RUA HUMAITA, 85 CJ 501, RIO DE JANEIRO, RJ, 22261-000, BRAZIL
SN 2359-3997
EI 2359-4292
J9 ARCH ENDOCRIN METAB
JI Arch. Endocrinol. Metab.
PD MAY-JUN
PY 2020
VL 64
IS 3
BP 319
EP 325
DI 10.20945/2359-3997000000238
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA MA0UB
UT WOS:000541630700018
PM 32267365
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU McIsaac, DI
   Huang, A
   Wong, CA
   Wijeysundera, DN
   Bryson, GL
   van Walraven, C
AF McIsaac, Daniel I.
   Huang, Allen
   Wong, Coralie A.
   Wijeysundera, Duminda N.
   Bryson, Gregory L.
   van Walraven, Carl
TI Effect of Preoperative Geriatric Evaluation on Outcomes After Elective
   Surgery: A Population-Based Study
SO JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
LA English
DT Article
DE surgery; geriatrician; outcomes; epidemiology
ID LATE-LIFE DEPRESSION; HOMEOSTASIS MODEL ASSESSMENT; METABOLIC SYNDROME;
   INSULIN-RESISTANCE; OLDER-ADULTS; VASCULAR DEPRESSION; TREATMENT
   RESPONSE; RATING-SCALE; RISK-FACTORS; ASSOCIATION
AB BACKGROUND/OBJECTIVES: Randomized and non-randomized single-center studies suggest that preoperative geriatric evaluation improves postoperative outcomes in older adults. The generalizability and population-level effect of preoperative geriatric evaluation has not been determined. Our objective was to measure the adjusted association between preoperative geriatric evaluation and postoperative outcomes.
   DESIGN: Multilevel multivariable regression model analysis of a population-based historical cohort.
   SETTING: Publicly funded universal healthcare system in Ontario, Canada.
   PARTICIPANTS: All adults aged 65 and older having major, elective, noncardiac surgery from 2002 to 2014 (N = 266,499).
   INTERVENTION: We studied geriatric consultations and comprehensive assessments performed in the 4 months prior to surgery. These were identified using validated methods.
   MEASUREMENTS: Ninety-day survival (primary outcome), in-hospital complications, length of stay, 30-day readmissions, need for supported discharge, and 90-day costs of care.
   RESULTS: The 7,352 participants (2.8%) who had a preoperative geriatric evaluation had longer 90-day survival than those who who did not (adjusted hazard ratio = 0.81, 95% confidence interval = 0.68-0.95). Length of stay and complication rates did not differ between groups, but participants evaluated by a geriatrician preoperatively had higher rates of supported discharge, readmission rates, and costs of care. Sensitivity analyses supported the association between preoperative geriatric assessment and 90-day survival.
   CONCLUSION: In individuals aged 65 and older undergoing major, elective, noncardiac surgery, preoperative geriatric evaluation was associated with longer 90-day survival, but it is used infrequently. Given these results, and those of previous small studies, the influence of a geriatric evaluation on postoperative outcomes should be determined in a multicenter randomized trial.
C1 [McIsaac, Daniel I.; Bryson, Gregory L.] Univ Ottawa, Dept Anesthesiol & Pain Med, Ottawa, ON, Canada.
   [McIsaac, Daniel I.; Huang, Allen; Bryson, Gregory L.; van Walraven, Carl] Ottawa Hosp, Ottawa, ON, Canada.
   [McIsaac, Daniel I.; Huang, Allen; Bryson, Gregory L.; van Walraven, Carl] Ottawa Hosp, Res Inst, Ottawa, ON, Canada.
   [McIsaac, Daniel I.; Wong, Coralie A.; Wijeysundera, Duminda N.; van Walraven, Carl] Inst Clin Evaluat Sci, Ottawa, ON, Canada.
   [McIsaac, Daniel I.; van Walraven, Carl] Univ Ottawa, Sch Epidemiol Publ Hlth & Prevent Med, Ottawa, ON, Canada.
   [Huang, Allen; van Walraven, Carl] Univ Ottawa, Dept Internal Med, Ottawa, ON, Canada.
   [Huang, Allen] Ottawa Hosp, Dept Geriatr Med, Ottawa, ON, Canada.
   [Wijeysundera, Duminda N.] Univ Toronto, Dept Anesthesiol, Toronto, ON, Canada.
   [Wijeysundera, Duminda N.] St Michaels Hosp, Li Ka Shing Knowledge Inst, Toronto, ON, Canada.
   [Wijeysundera, Duminda N.] Toronto Gen Hosp, Dept Anesthesia & Pain Med, Toronto, ON, Canada.
C3 University of Ottawa; University of Ottawa; Ottawa Hospital Research
   Institute; University of Ottawa; Ottawa Hospital Research Institute;
   University of Ottawa; University of Ottawa; University of Ottawa; Ottawa
   Hospital Research Institute; University of Toronto; University of
   Toronto; Saint Michaels Hospital Toronto; Li Ka Shing Knowledge
   Institute; University of Toronto; University Health Network Toronto;
   Toronto General Hospital
RP McIsaac, DI (corresponding author), 1053 Carling Ave,Room B311, Ottawa, ON K1Y 4E9, Canada.
EM dmcisaac@toh.ca
RI ; Bryson, Gregory/AAG-5108-2019; Wijeysundera, Duminda/L-3350-2018
OI McIsaac, Daniel/0000-0002-8543-1859; Bryson,
   Gregory/0000-0003-3583-9802; Wijeysundera, Duminda/0000-0002-5897-8605;
   Huang, Allen/0000-0003-2680-7657
FU Canadian Anesthesiologists Society Dr. RA Gordon Research Award for
   Innovation in Patient Safety; Department of Anesthesiology, The
   University of Ottawa; Institute for Clinical Evaluative Sciences;
   Ontario Ministry of Health and Long-Term Care (MOHLTC); Ottawa Hospital
   Department of Anesthesiology Alternate Funds Association; Canadian
   Institutes of Health Research; Department of Anesthesia at the
   University of Toronto; University of Ottawa Department of Medicine
   Clinician Scientist Chair
FX We acknowledge the peer-reviewed funding from the Canadian
   Anesthesiologists Society Dr. RA Gordon Research Award for Innovation in
   Patient Safety, and the Department of Anesthesiology, The University of
   Ottawa. This study was also supported by the Institute for Clinical
   Evaluative Sciences, which is funded by an annual grant from the Ontario
   Ministry of Health and Long-Term Care (MOHLTC). The opinions, results
   and conclusions reported in this paper are those of the authors and are
   independent from the funding sources. No endorsement by ICES or the
   Ontario MOHLTC is intended or should be inferred. These data sets were
   held securely in a linked, de-identified form and analyzed at ICES.
   Daniel I McIsaac was supported by the Ottawa Hospital Department of
   Anesthesiology Alternate Funds Association. Duminda N. Wijeysundera is
   supported by in part by a New Investigator Award from the Canadian
   Institutes of Health Research and a Merit Award from the Department of
   Anesthesia at the University of Toronto. Carl van Walraven is supported
   by a University of Ottawa Department of Medicine Clinician Scientist
   Chair.
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NR 47
TC 30
Z9 31
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0002-8614
EI 1532-5415
J9 J AM GERIATR SOC
JI J. Am. Geriatr. Soc.
PD DEC
PY 2017
VL 65
IS 12
BP 2665
EP 2672
DI 10.1111/jgs.15100
PG 8
WC Geriatrics & Gerontology; Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA FP7SD
UT WOS:000417836200019
PM 28971482
DA 2025-06-11
ER

PT J
AU Chang, HH
   Chi, MH
   Lee, IH
   Tsai, HC
   Gean, PW
   Yang, YK
   Lu, RB
   Chen, PS
AF Chang, Hui Hua
   Chi, Mei Hung
   Lee, I. Hui
   Tsai, Hsin Chun
   Gean, Po Wu
   Yang, Yen Kuang
   Lu, Ru-Band
   Chen, Po See
TI The change of insulin levels after six weeks antidepressant use in
   drug-naive major depressive patients
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Major depressive disorder; Antidepressant; Insulin; HOMA index
ID VESICULAR MONOAMINE TRANSPORTER-2; HOMEOSTASIS MODEL ASSESSMENT;
   PANCREATIC BETA-CELL; DIABETES-MELLITUS; METABOLIC SYNDROME;
   BIDIRECTIONAL ASSOCIATION; MEDICATION USE; PLASMA TRYPTOPHAN; GLYCEMIC
   CONTROL; RISK
AB Background: A reciprocal relationship between diabetes risk and depression has been reported. There are few studies investigating glucose insulin homeostasis before and after short-term antidepressant treatment in drug naive major depressive disorder (MDD) patients.
   Methods: This study included 104 healthy controls and 50 drug naive MDD patients diagnosed according to the DSM-IV criteria. These MDD patients were randomly assigned to receive fluoxetine or venlafaxine for six weeks. Depressive symptoms, body mass index, fasting plasma levels of glucose and insulin were measured.
   Results: Compared to the healthy controls, the fasting plasma insulin and the homeostasis model of assessment for pancreatic beta-cell secretory function (HOMA-beta) was significantly lower in the MDD patients before antidepressant treatment (7.7 +/- 4.8 vs. mu IU/mL vs. 5.1 +/- 4.2 mu IU/mL, p=0.006; 114.2 +/- 72.3% vs. 74.8 +/- 52.0%, p=0.005, respectively). However, these indices were not correlated with depression severity. After 6 weeks of fluoxetine or venlafaxine treatment, the level of HOMA-beta borderline significantly increased (108.1 +/- 75.5%, p=0.059).
   Limitations: The study was limited by the follow-up duration and lack of a placebo group.
   Conclusions: Antidepressants might affect insulin secretion independently of the therapeutic effects On MDD. Further studies are needed to investigate the long-term effects of antidepressants On insulin regulation in MDD patients. (C) 2013 Elsevier B.V. All rights reserved.
C1 [Chang, Hui Hua] Natl Cheng Kung Univ, Inst Clin Pharm & Pharmaceut Sci, Coll Med, Tainan 704, Taiwan.
   [Chi, Mei Hung; Lee, I. Hui; Tsai, Hsin Chun; Yang, Yen Kuang; Lu, Ru-Band; Chen, Po See] Natl Cheng Kung Univ, Natl Cheng Kung Univ Hosp, Coll Med, Dept Psychiat, Tainan 704, Taiwan.
   [Lee, I. Hui; Yang, Yen Kuang; Lu, Ru-Band; Chen, Po See] Natl Cheng Kung Univ, Addict Res Ctr, Tainan 704, Taiwan.
   [Tsai, Hsin Chun] Natl Cheng Kung Univ, Dou Liou Branch, Dept Psychiat, Yunlin, Taiwan.
   [Gean, Po Wu] Natl Cheng Kung Univ, Dept Pharmacol, Coll Med, Tainan 704, Taiwan.
C3 National Cheng Kung University; National Cheng Kung University; National
   Cheng Kung University Hospital; National Cheng Kung University; National
   Cheng Kung University; National Cheng Kung University
RP Chen, PS (corresponding author), Natl Cheng Kung Univ, Dept Psychiat, Coll Med, 138 Sheng Li Rd, Tainan 704, Taiwan.
EM chenps@mail.ncku.edu.tw
RI Chang, Hui/AGD-4270-2022; Chen, Po/AAA-6492-2021
OI Chang, Hui Hua/0000-0001-7866-5481
FU Department of Health, Taiwan [DOH96-TD-D-113-041]; National Science
   Council, Taiwan [NSC 98-2627-B-006-016, NSC 100-2627-B-006-012]
FX This study was supported by Grants from the Department of Health, Taiwan
   (DOH96-TD-D-113-041), and the National Science Council, Taiwan (NSC
   98-2627-B-006-016, NSC 100-2627-B-006-012).
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NR 49
TC 19
Z9 22
U1 2
U2 15
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0165-0327
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD SEP 5
PY 2013
VL 150
IS 2
BP 295
EP 299
DI 10.1016/j.jad.2013.04.008
PG 5
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA 206YQ
UT WOS:000323563300017
PM 23664565
DA 2025-06-11
ER

PT J
AU Siegler, IC
   Costa, PT
   Brummett, BH
   Helms, MJ
   Barefoot, JC
   Williams, RD
   Dahlstrom, WG
   Kaplan, BH
   Vitaliano, PP
   Nichaman, MZ
   Day, RS
   Rimer, BK
AF Siegler, IC
   Costa, PT
   Brummett, BH
   Helms, MJ
   Barefoot, JC
   Williams, RD
   Dahlstrom, WG
   Kaplan, BH
   Vitaliano, PP
   Nichaman, MZ
   Day, RS
   Rimer, BK
TI Patterns of change in hostility from college to midlife in the UNC
   alumni heart study predict high-risk status
SO PSYCHOSOMATIC MEDICINE
LA English
DT Article
DE hostility; age; patterns of change; health risk; risk trajectories
ID ACUTE MYOCARDIAL-INFARCTION; PSYCHOLOGICAL RISK; METABOLIC SYNDROME;
   AGE-DIFFERENCES; TOTAL MORTALITY; CHD INCIDENCE; LIFE-SPAN; DISEASE;
   PERSONALITY; HEALTH
AB Objective: To examine hostility measured in college and patterns of change in hostility from college to midlife as predictors of high health-related risk later in midlife. Methods: Logistic regression models were used to test hostility/risk associations. Results: College hostility predicted being a current smoker, consuming more than two drinks of alcohol, low social support, achieving less than expected in career and in relationships, risk for depression, and appraisal of life changing for the worse in terms of family events at midlife. Change in hostility did not predict smoking and drinking; however, it did significantly predict social isolation, lower income (only for women), obesity, avoidance of exercise, high-fat diet, and negative changes in economic life, work life, and physical health events-all risk indicators measured during the next decade. Appraisals of social support, lowered expectations, risk for depression, and reports of family life changing for the worse were predicted at both time periods. When change in hostility was modeled with college hostility, all risk indicators were significantly predicted by college hostility. Conclusions: High hostility in college and change in hostility from college to midlife predicts a full range of health risk indicators. When compared with the average population decline in hostility, gains in hostility at midlife are related to increased risk while declines in hostility are related to reduced risk. Higher midlife hostility is associated with increased odds of being in the higher risk group. Future research should focus on developing interventions to reduce hostility.
C1 Duke Univ, Med Ctr, Dept Psychiat & Behav Sci, Durham, NC 27710 USA.
   Duke Univ, Med Ctr, Behav Med Res Ctr, Durham, NC 27710 USA.
   Univ N Carolina, Dept Psychol, Chapel Hill, NC 27599 USA.
   Univ N Carolina, Sch Publ Hlth, Dept Epidemiol, Chapel Hill, NC 27599 USA.
   NIA, Gerontol Res Ctr, Intramural Res Program, Lab Personal & Cognit, Baltimore, MD 21224 USA.
   Univ Washington, Dept Psychiat & Behav Sci, Seattle, WA 98195 USA.
   Univ Texas, Sch Publ Hlth, Ctr Human Nutr, Houston, TX 77225 USA.
   Univ N Carolina, Sch Publ Hlth, Dept Hlth Behav & Hlth Educ, Chapel Hill, NC 27599 USA.
   Univ N Carolina, Lineberger Canc Ctr, Chapel Hill, NC 27599 USA.
C3 Duke University; Duke University; University of North Carolina;
   University of North Carolina Chapel Hill; University of North Carolina;
   University of North Carolina Chapel Hill; National Institutes of Health
   (NIH) - USA; NIH National Institute on Aging (NIA); University of
   Washington; University of Washington Seattle; University of Texas
   System; University of Texas Health Science Center Houston; University of
   Texas School Public Health; University of North Carolina; University of
   North Carolina Chapel Hill; University of North Carolina; University of
   North Carolina Chapel Hill
RP Duke Univ, Med Ctr, Dept Psychiat & Behav Sci, Durham, NC 27710 USA.
EM ilene.siegler@duke.edu
RI Costa, Paul/AAH-6594-2019; Vitaliano, Peter/K-2014-2019
OI Vitaliano, peter P./0000-0003-1598-0868; Costa, Paul/0000-0003-4375-1712
FU NCI NIH HHS [P01 CA72099] Funding Source: Medline; NHLBI NIH HHS [R01
   HL055356, P01 HL036587, P01 HL36578, R01 HL54780, R01 HL55356] Funding
   Source: Medline; NIA NIH HHS [R01 AG12458] Funding Source: Medline; NIMH
   NIH HHS [R01 MH 57663] Funding Source: Medline
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NR 68
TC 65
Z9 74
U1 0
U2 9
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0033-3174
EI 1534-7796
J9 PSYCHOSOM MED
JI Psychosom. Med.
PD SEP-OCT
PY 2003
VL 65
IS 5
BP 738
EP 745
DI 10.1097/01.PSY.0000088583.25140.9C
PG 8
WC Psychiatry; Psychology; Psychology, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry; Psychology
GA 727QQ
UT WOS:000185670300003
PM 14508014
DA 2025-06-11
ER

PT J
AU Alemany-Navarro, M
   Diz-de Almeida, S
   Cruz, R
   Riancho, JA
   Rojas-Martínez, A
   Lapunzina, P
   Flores, C
   Carracedo, A
AF Alemany-Navarro, M.
   Diz-de Almeida, S.
   Cruz, R.
   Riancho, J. A.
   Rojas-Martinez, A.
   Lapunzina, P.
   Flores, C.
   Carracedo, A.
CA Scourge Cohort Grp
TI Psychiatric polygenic risk as a predictor of COVID-19 risk and severity:
   insight into the genetic overlap between schizophrenia and COVID-19
SO TRANSLATIONAL PSYCHIATRY
LA English
DT Article
ID METABOLIC SYNDROME; BIPOLAR DISORDER; DISEASES; IMMUNE; INFLAMMATION;
   METAANALYSIS; ASSOCIATION; PREVALENCE; DEPRESSION; MORTALITY
AB Despite the high contagion and mortality rates that have accompanied the coronavirus disease-19 (COVID-19) pandemic, the clinical presentation of the syndrome varies greatly from one individual to another. Potential host factors that accompany greater risk from COVID-19 have been sought and schizophrenia (SCZ) patients seem to present more severe COVID-19 than control counterparts, with certain gene expression similarities between psychiatric and COVID-19 patients reported. We used summary statistics from the last SCZ, bipolar disorder (BD), and depression (DEP) meta-analyses available on the Psychiatric Genomics Consortium webpage to calculate polygenic risk scores (PRSs) for a target sample of 11,977 COVID-19 cases and 5943 subjects with unknown COVID-19 status. Linkage disequilibrium score (LDSC) regression analysis was performed when positive associations were obtained from the PRS analysis. The SCZ PRS was a significant predictor in the case/control, symptomatic/asymptomatic, and hospitalization/no hospitalization analyses in the total and female samples; and of symptomatic/asymptomatic status in men. No significant associations were found for the BD or DEP PRS or in the LDSC regression analysis. SNP-based genetic risk for SCZ, but not for BD or DEP, may be associated with higher risk of SARS-CoV-2 infection and COVID-19 severity, especially among women; however, predictive accuracy barely exceeded chance level. We believe that the inclusion of sexual loci and rare variations in the analysis of genomic overlap between SCZ and COVID-19 will help to elucidate the genetic commonalities between these conditions.
C1 [Alemany-Navarro, M.] Univ Seville, IBIS, HUVR, Junta Andalucia,CSIC, Seville, Spain.
   [Alemany-Navarro, M.; Diz-de Almeida, S.; Cruz, R.; Carracedo, A.] Univ Santiago Compostela, Ctr Singular Invest Med Mol & Enfermedades Cron CI, Santiago De Compostela, Spain.
   [Alemany-Navarro, M.; Carracedo, A.] Fdn Publ Galega Med Xen, Sistema Galego Saude SERGAS Santiago Compostela, Santiago De Compostela, Spain.
   [Alemany-Navarro, M.; Carracedo, A.] Inst Invest Sanitaria Santiago IDIS, Grp Genet, Santiago De Compostela, Spain.
   [Diz-de Almeida, S.; Cruz, R.; Lapunzina, P.; Carracedo, A.] Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Raras CIBERER I, Madrid, Spain.
   [Riancho, J. A.] IDIVAL, Cantabria, Spain.
   [Riancho, J. A.] Univ Cantabria, Cantabria, Spain.
   [Riancho, J. A.] Hosp UM Valdecilla, Cantabria, Spain.
   [Rojas-Martinez, A.] Tecnol Monterrey, Escuela Med & Ciencias Salud, Monterrey, Mexico.
   [Lapunzina, P.] Hosp Univ La Paz, Inst Genet Med & Mol INGEMM, Madrid, Spain.
   [Lapunzina, P.] ERN ITHACA European Reference Network, Santa Cruz De Tenerife, Canarias, Spain.
   [Flores, C.] Hosp Univ NS Candelaria, Res Unit, Santa Cruz De Tenerife, Spain.
   [Flores, C.] Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Respiratorias, Madrid, Spain.
   [Flores, C.] Inst Tecnol & Energias Renovables, Genom Div, Santa Cruz De Tenerife, Spain.
   [Flores, C.] Univ Fernando Pessoa Canarias, Dept Clin Sci, Las Palmas Gran Canaria, Spain.
C3 Consejo Superior de Investigaciones Cientificas (CSIC); University of
   Sevilla; CSIC-JA-USE - Instituto de Biomedicina de Sevilla (IBIS);
   Universidade de Santiago de Compostela; Instituto de Salud Carlos III;
   Universidad de Cantabria; Hospital Universitario Marques de Valdecilla
   (HUMV); Tecnologico de Monterrey; Hospital Universitario La Paz; CIBER -
   Centro de Investigacion Biomedica en Red; CIBERES; Instituto de Salud
   Carlos III; Universidad Fernando Pessoa Canarias
RP Alemany-Navarro, M (corresponding author), Univ Seville, IBIS, HUVR, Junta Andalucia,CSIC, Seville, Spain.; Alemany-Navarro, M (corresponding author), Univ Santiago Compostela, Ctr Singular Invest Med Mol & Enfermedades Cron CI, Santiago De Compostela, Spain.; Alemany-Navarro, M (corresponding author), Fdn Publ Galega Med Xen, Sistema Galego Saude SERGAS Santiago Compostela, Santiago De Compostela, Spain.; Alemany-Navarro, M (corresponding author), Inst Invest Sanitaria Santiago IDIS, Grp Genet, Santiago De Compostela, Spain.
EM malemany-ibis@us.es
RI ROJAS-MARTINEZ, AUGUSTO/Z-3585-2019; Carracedo, Angel/D-4257-2012;
   Rodriguez, Jose/G-7324-2015; Alemany-Navarro, María/ACJ-7620-2022;
   ROJAS-MARTINEZ, AUGUSTO/D-1710-2011; Meijome, Xose Manuel/G-1743-2010;
   Minguez, Pablo/D-4822-2013; Victor, Moreno-Cuerda/G-3851-2016
OI Albu, Sergiu/0000-0001-8310-4208; Carpio, Carlos/0000-0003-4090-4306;
   Diz de Almeida, Silvia/0000-0003-2813-8928; Villoslada-Blanco,
   Pablo/0000-0002-1220-5228; Tenorio, Jair Antonio/0000-0002-5308-2316;
   Rosales Castillo, Antonio/0000-0001-9637-2025; Gutierrez-Bautista, Juan
   Francisco/0000-0003-1374-0756; ROJAS-MARTINEZ,
   AUGUSTO/0000-0003-3765-6778; Meijome, Xose Manuel/0000-0001-9080-6582;
   Laorden, Daniel/0000-0001-9054-5925; Alemany Navarro,
   Maria/0000-0002-8491-0137; Cortes Sanchez, Jose
   Luis/0000-0002-4646-9520; lattig, claudia/0000-0003-2113-9266; Minguez,
   Pablo/0000-0003-4099-9421; CRUZ, RAQUEL/0000-0002-6964-8898; Mercado
   Sesma, Arieh Roldan/0000-0002-9025-9328; Alves dos Santos,
   Katiusse/0000-0001-7514-0989; Corton, Marta/0000-0003-0087-1626; Victor,
   Moreno-Cuerda/0000-0003-0262-8216
FU Fundacion Maria Jose Jove; Instituto de Salud Carlos III [COV20_00622];
   European Union (ERDF) "A way of making Europe"; Fundacion Amancio
   Ortega; Banco de Santander; Centro National de Genotipado (CEGEN);
   Centro de Supercomputacion de Galicia (CESGA); Juan de la Cierva
   contract [FJC2021-047538-I]
FX MA, and AC acknowledge Fundacion Maria Jose Jove for the support of this
   work. This study has been funded by Instituto de Salud Carlos III
   (COV20_00622 to AC) and cofunded by European Union (ERDF) "A way of
   making Europe", Fundacion Amancio Ortega, Banco de Santander (to AC).
   The contribution of the Centro National de Genotipado (CEGEN), and
   Centro de Supercomputacion de Galicia (CESGA) for funding this project
   by providing supercomputing infrastructures, is also acknowledged.
   Authors are also particularly grateful to Banco Nacional de ADN and
   GRA@CE cohort group. MA was supported by a Juan de la Cierva contract
   (FJC2021-047538-I).
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NR 101
TC 5
Z9 5
U1 0
U2 4
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 2158-3188
J9 TRANSL PSYCHIAT
JI Transl. Psychiatr.
PD JUN 6
PY 2023
VL 13
IS 1
AR 189
DI 10.1038/s41398-023-02482-7
PG 8
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychiatry
GA I4TP6
UT WOS:001002724500002
PM 37280221
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Crespo-Facorro, B
   Such, P
   Nylander, AG
   Madera, J
   Resemann, HK
   Worthington, E
   O'Connor, M
   Drane, E
   Steeves, S
   Newton, R
AF Crespo-Facorro, Benedicto
   Such, Pedro
   Nylander, Anna-Greta
   Madera, Jessica
   Resemann, Henrike K.
   Worthington, Emma
   O'Connor, Molly
   Drane, Emma
   Steeves, Sara
   Newton, Richard
TI The burden of disease in early schizophrenia - a systematic literature
   review
SO CURRENT MEDICAL RESEARCH AND OPINION
LA English
DT Review
DE Schizophrenia; cost of illness; quality of life; morbidity
ID QUALITY-OF-LIFE; 1ST EPISODE; 1ST-EPISODE SCHIZOPHRENIA; UNTREATED
   PSYCHOSIS; CLINICAL CHARACTERISTICS; METABOLIC SYNDROME;
   MENTAL-DISORDERS; HIGH-RISK; ONSET; DEPRESSION
AB Background
   Schizophrenia is a heterogeneous disorder with a burden that can vary greatly depending on the severity and the duration. Previous research has suggested that patients in the earlier stages of schizophrenia (typically first-episode schizophrenia) benefit from effective early treatment, however, a comprehensive review of the burden specifically in this population has not been undertaken. A systematic literature review was therefore conducted to characterize the clinical, economic, and humanistic burden, as reported in naturalistic studies of schizophrenia populations specifically at an early stage of disease in comparison with healthy controls, patients with chronic schizophrenia, and patients with other psychiatric disorders.
   Methods and materials
   Searches were conducted in MEDLINE, MEDLINE In-Process, Embase, PsycINFO, and EconLit databases for records published between January 2005 and April 2019, and of relevant conference abstracts published between January 2014 and May 2019. Data were extracted from relevant publications and subjected to qualitative evaluation.
   Results
   Fifty-two publications were identified for inclusion and revealed a considerable burden for early schizophrenia with regards to mortality, psychiatric comorbidities such as substance abuse and depression, poor social functioning, and unemployment. Comparisons with chronic schizophrenia suggested a greater burden with longer disease duration, while comparisons with other psychiatric disorders were inconclusive. This review uncovered various gaps in the available literature, including limited or no data on incarcerations, caregiver burden, and costs associated with early schizophrenia.
   Conclusions
   Overall, the burden of schizophrenia is apparent even in the early stages of the disease, although further research is required to quantify the burden with chronic schizophrenia and other psychiatric disorders.
C1 [Crespo-Facorro, Benedicto] Univ Hosp Virgen Rocio, Ctr Invest Biomed Red Salud Mental CIBERSAM, Dept Med & Psychiat, IBiS, Seville, Spain.
   [Such, Pedro; Nylander, Anna-Greta] H Lundbeck & Co AS, Ottiliavej 9, DK-2500 Valby, Denmark.
   [Madera, Jessica] Otsuka Pharmaceut Dev & Commercializat Inc, Global Med Affairs, Princeton, NJ USA.
   [Resemann, Henrike K.; Worthington, Emma; O'Connor, Molly; Drane, Emma; Steeves, Sara] Costello Med Consulting Ltd, Cambridge, England.
   [Newton, Richard] Monash Univ, Peninsula Hlth, Frankston, Vic, Australia.
C3 Virgen del Rocio University Hospital; Consejo Superior de
   Investigaciones Cientificas (CSIC); University of Sevilla; CSIC-JA-USE -
   Instituto de Biomedicina de Sevilla (IBIS); CIBER - Centro de
   Investigacion Biomedica en Red; CIBERSAM; Lundbeck Corporation; Otsuka
   Pharmaceutical; Costello Medical Consulting; Peninsula Health; Monash
   University
RP Nylander, AG (corresponding author), H Lundbeck & Co AS, Ottiliavej 9, DK-2500 Valby, Denmark.
EM AGN@Lundbeck.com
RI Crespo-Facorro, BENEDICTO/AAY-2238-2021
OI Crespo-Facorro, Benedicto/0000-0003-0033-7132
FU H. Lundbeck A/S; Otsuka Pharmaceutical Europe Ltd.
FX This work was supported by H. Lundbeck A/S and Otsuka Pharmaceutical
   Europe Ltd.
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NR 78
TC 47
Z9 50
U1 7
U2 26
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0300-7995
EI 1473-4877
J9 CURR MED RES OPIN
JI Curr. Med. Res. Opin.
PD JAN 2
PY 2021
VL 37
IS 1
BP 109
EP 121
DI 10.1080/03007995.2020.1841618
EA NOV 2020
PG 13
WC Medicine, General & Internal; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine; Research & Experimental Medicine
GA PZ5LT
UT WOS:000589109800001
PM 33095689
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Su, Q
   Gu, YQ
   Yu, B
   Yu, F
   He, HY
   Zhang, Q
   Meng, G
   Wu, HM
   Du, HM
   Liu, L
   Shi, HB
   Xia, Y
   Guo, XY
   Liu, X
   Li, CL
   Bao, X
   Liu, FF
   Fang, LY
   Yang, HJ
   Sun, SM
   Wang, X
   Zhou, M
   Jia, QY
   Zhao, HL
   Song, K
   Niu, KJ
AF Su, Qian
   Gu, Yeqing
   Yu, Bin
   Yu, Fei
   He, Haiyan
   Zhang, Qing
   Meng, Ge
   Wu, Hongmei
   Du, Huanmin
   Liu, Li
   Shi, Hongbin
   Xia, Yang
   Guo, Xiaoyan
   Liu, Xing
   Li, Chunlei
   Bao, Xue
   Liu, Fangfang
   Fang, Liyun
   Yang, Huijun
   Sun, Shaomei
   Wang, Xing
   Zhou, Ming
   Jia, Qiyu
   Zhao, Honglin
   Song, Kun
   Niu, Kaijun
TI Association between Serum Ferritin Concentrations and Depressive
   Symptoms among Chinese Adults: A Population Study from the Tianjin
   Chronic Low-Grade Systemic Inflammation and Health (TCLSIHealth) Cohort
   Study
SO PLOS ONE
LA English
DT Article
ID MAJOR DEPRESSION; IRON STATUS; METABOLIC SYNDROME; DISORDERS; RISK;
   PREVALENCE; GENDER; AXIS
AB Depressive symptoms have become the most important global public health issue. Iron plays an important role in brain function, cognition, and behavior, and its impacts on depressive symptoms may be multifactorial with both positive and negative effects. Previous observational studies focusing on the association between iron status and depressive symptoms showed inconsistent results. Ferritin is a ubiquitous intracellular protein that can store and release iron and is widely used as a clinical biomarker to evaluate iron status. We performed a cross-sectional study to examine the relationship between serum ferritin and depressive symptoms among 3,839 subjects who were from the Tianjin Chronic Low-grade Systemic Inflammation and Health (TCLSIHealth) cohort. Depressive symptoms were assessed using the Chinese version of 20-item self-rating Depression Scale (SDS) with 4 cutoffs (40, 45, 48 and 50) to indicate elevated depressive symptoms (40 was the primary cut-off). The prevalence of depressive symptoms was 36.5%, 17.6%, 11.0% and 7.0% for SDS >= 40, >= 45, >= 48 and >= 50, respectively. With the primary cut-off point of 40, multiple potential confounding factors were adjusted and the odds ratios (95% confidence interval) of having elevated depressive symptoms by quartiles of serum ferritin concentrations were 1.00 (reference), 1.10 (0.91, 1.34), 0.81 (0.66, 1.01) and 1.02 (0.81, 1.28) for the first, second, third and fourth quartile, respectively (P for trend = 0.76). Similar relations were observed with the use of other cut-offs as a definition of depressive symptoms. In conclusion, there is no significant relationship between serum ferritin concentrations and depressive symptoms among Chinese adults.
C1 [Su, Qian; Gu, Yeqing; Yu, Bin; Yu, Fei; He, Haiyan; Meng, Ge; Wu, Hongmei; Du, Huanmin; Xia, Yang; Guo, Xiaoyan; Liu, Xing; Li, Chunlei; Bao, Xue; Liu, Fangfang; Fang, Liyun; Yang, Huijun; Niu, Kaijun] Tianjin Med Univ, Nutr Epidemiol Inst, Tianjin, Peoples R China.
   [Su, Qian; Gu, Yeqing; Yu, Bin; Yu, Fei; He, Haiyan; Meng, Ge; Wu, Hongmei; Du, Huanmin; Xia, Yang; Guo, Xiaoyan; Liu, Xing; Li, Chunlei; Bao, Xue; Liu, Fangfang; Fang, Liyun; Yang, Huijun; Niu, Kaijun] Tianjin Med Univ, Sch Publ Hlth, Tianjin, Peoples R China.
   [Zhang, Qing; Liu, Li; Shi, Hongbin; Sun, Shaomei; Wang, Xing; Zhou, Ming; Jia, Qiyu; Zhao, Honglin; Song, Kun; Niu, Kaijun] Tianjin Med Univ, Gen Hosp, Hlth Management Ctr, Tianjin, Peoples R China.
   [Yu, Bin] Tianjin Med Univ, Inst Psychol, Tianjin, Peoples R China.
   [Niu, Kaijun] Tianjin Med Univ, Collaborat Innovat Ctr Noncommunicable Dis, Tianjin, Peoples R China.
C3 Tianjin Medical University; Tianjin Medical University; Tianjin Medical
   University; Tianjin Medical University; Tianjin Medical University
RP Niu, KJ (corresponding author), Tianjin Med Univ, Nutr Epidemiol Inst, Tianjin, Peoples R China.; Niu, KJ (corresponding author), Tianjin Med Univ, Sch Publ Hlth, Tianjin, Peoples R China.; Niu, KJ (corresponding author), Tianjin Med Univ, Gen Hosp, Hlth Management Ctr, Tianjin, Peoples R China.; Niu, KJ (corresponding author), Tianjin Med Univ, Collaborat Innovat Ctr Noncommunicable Dis, Tianjin, Peoples R China.
EM niukaijun@tmu.edu.cn
RI YANG, June/AHC-4229-2022; LI, Cheuk-Wing/I-3255-2014; Niu,
   Kaijun/ADD-6222-2022; Xia, Yang/AAW-9116-2021; Gu, Yeqing/S-3103-2017;
   LIU, Fangfang/GNH-4322-2022; Yu, Bin/AAV-1606-2020
OI Yu, Bin/0000-0002-8978-5144; Niu, Kaijun/0000-0002-8772-2481; Xia,
   Yang/0000-0001-8783-1592
FU National Natural Science Foundation of China [81673166, 81372118,
   81372467, 81302422]; key technologies R&D program of Tianjin
   [11ZCGYSY05700, 12ZCZDSY20400, 13ZCZDSY20200]; National Science and
   Technology Support Program [2012BAI02B02]; Chinese Nutrition Society
   (CNS) Nutrition Research Foundation-DSM Research Fund [2014-071];
   Technologies development program of Beichen District of Tianjin
   [bcws2013-21, bcws2014-05]; technologies project of Tianjin Binhai New
   Area [2013-02-04, 2013-02-06]; Science Foundation of Tianjin Medical
   University [2010KY28, 2013KYQ24]; Ministry of Education [GW2014-5];
   National Training Programs of Innovation and Entrepreneurship for
   Undergraduates, China [201510062013]; Key Laboratory of Public Health
   Safety (Fudan University)
FX This study was supported by grants from the National Natural Science
   Foundation of China (No. 81673166, 81372118, 81372467 and 81302422), the
   key technologies R&D program of Tianjin (Key Project: No. 11ZCGYSY05700,
   12ZCZDSY20400, and 13ZCZDSY20200), the National Science and Technology
   Support Program (No. 2012BAI02B02), 2012 Chinese Nutrition Society (CNS)
   Nutrition Research Foundation-DSM Research Fund (No. 2014-071), the
   Technologies development program of Beichen District of Tianjin (No.
   bcws2013-21 and bcws2014-05), the technologies project of Tianjin Binhai
   New Area (No. 2013-02-04 and 2013-02-06), the Science Foundation of
   Tianjin Medical University (No. 2010KY28 and 2013KYQ24), the Key
   Laboratory of Public Health Safety (Fudan University), Ministry of
   Education (No. GW2014-5), and the National Training Programs of
   Innovation and Entrepreneurship for Undergraduates (No. 201510062013),
   China.
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NR 47
TC 8
Z9 11
U1 0
U2 7
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD SEP 9
PY 2016
VL 11
IS 9
AR e0162682
DI 10.1371/journal.pone.0162682
PG 12
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Science & Technology - Other Topics
GA DV9JE
UT WOS:000383255900151
PM 27611581
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Misiak, B
   Stramecki, F
   Kasznia, J
   Lis, M
   Stanczykiewicz, B
AF Misiak, Blazej
   Stramecki, Filip
   Kasznia, Justyna
   Lis, Michal
   Stanczykiewicz, Bartlomiej
TI Adiponectin levels in patients with bipolar disorder: A systematic
   review and meta-analysis
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Review
DE Mania; Depression; Adiposity; Inflammation; Immunity
ID MAJOR DEPRESSIVE DISORDER; METABOLIC SYNDROME; SERUM-LEVELS; CYTOKINE
   LEVELS; DYSFUNCTION; LEPTIN; OVERWEIGHT; ADIPOKINES; SCHIZOPHRENIA;
   PREVALENCE
AB Bipolar disorder (BD) is associated with high prevalence rates of obesity-related conditions and subclinical inflammation. Adiponectin is produced by adipose tissue and exerts anti-inflammatory activities. We aimed to perform a systematic review and meta-analysis of studies investigating adiponectin levels in BD patients and healthy controls. Electronic databases were searched from their inception until 15th Jan 2019. Random-effects models with the Hedges' g as the effect size (ES) estimate were used. We included 11 studies, representing 477 patients and 380 controls. Pooled data analysis revealed no significant differences in adiponectin levels between BD patients and controls (ES = 0.28, 95%CI: -0.34 0.90, p = 0.372). The levels of adiponectin were significantly higher during euthymia (ES = 1.09, 95%CI: 0.03-2.16, p = 0.044). The levels of adiponectin in depressed patients were lower, but this result did not reach statistical significance (ES = -0.90, 95%CI: -1.85 - 0.05, p = 0.063). Due to low number of studies, the subgroup analysis of manic patients was not performed; however, a severity of manic symptoms was not associated with the ES estimates. Longer illness duration and a higher percentage of BD type I (BD-I) patients were associated with higher ES estimates. A higher severity of depressive symptoms was associated with lower ES estimates. Heterogeneity was significant in all analyses. Results of the Egger's test were insignificant, showing no publication bias. Our results indicate that adiponectin might be a state marker of BD as it appears to be elevated in euthymia and decreased in depression. Illness progression and a diagnosis of BD-I might contribute to higher adiponectin levels.
C1 [Misiak, Blazej] Wroclaw Med Univ, Dept Genet, Marcinkowskiego 1 St, PL-50368 Wroclaw, Poland.
   [Stramecki, Filip] Wroclaw Med Univ, Dept Psychiat, Pasteura 10 St, PL-50367 Wroclaw, Poland.
   [Kasznia, Justyna] Municipal Gen Hosp, Inpatient Psychiat Unit, Limanowskiego 20-22 St, PL-63400 Ostrow Wielkopolski, Poland.
   [Lis, Michal] Minist Interior Warsaw, Cent Clin Hosp, Clin Dept Internal Dis Endocrinol & Diabetol, Woloska 137 St, PL-02507 Warsaw, Poland.
   [Stanczykiewicz, Bartlomiej] Wroclaw Med Univ, Dept Nervous Syst Dis, Bartla 5 St, PL-51618 Wroclaw, Poland.
C3 Wroclaw Medical University; Wroclaw Medical University; Wroclaw Medical
   University
RP Misiak, B (corresponding author), Wroclaw Med Univ, Dept Genet, Marcinkowskiego 1 St, PL-50368 Wroclaw, Poland.
EM blazej_misiak@interia.pl
RI Misiak, Błażej/ABA-2657-2021; Stramecki, Filip/N-7599-2017;
   Stanczykiewicz, Bartlomiej/J-5742-2017
OI Stramecki, Filip/0000-0002-5326-8778; Stanczykiewicz,
   Bartlomiej/0000-0001-9221-3502; Misiak, Blazej/0000-0002-5392-6398; Lis,
   Michal/0000-0001-7675-398X
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NR 51
TC 9
Z9 9
U1 0
U2 7
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
EI 1873-3360
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD JUN
PY 2019
VL 104
BP 74
EP 79
DI 10.1016/j.psyneuen.2019.02.019
PG 6
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA HZ3AF
UT WOS:000468719200010
PM 30818254
DA 2025-06-11
ER

PT J
AU Daniele, TMD
   de Bruin, VMS
   Forte, ACE
   de Oliveira, DSN
   Pompeu, CMR
   de Bruin, PFC
AF da Costa Daniele, Thiago Medeiros
   Sales de Bruin, Veralice Meireles
   Costa e Forte, Adriana
   Nobre de Oliveira, Debora Siqueira
   Randal Pompeu, Clara Mota
   Carvalhedo de Bruin, Pedro Felipe
TI The relationship between physical activity, restless legs syndrome, and
   health-related quality of life in type 2 diabetes
SO ENDOCRINE
LA English
DT Article
DE Type 2 diabetes; Restless leg syndrome; Physical activity; Quality of
   life; Pain relieve; Functional capacity
ID DAYTIME SLEEPINESS; METABOLIC SYNDROME; PREVALENCE; EXERCISE;
   DEPRESSION; EPIDEMIOLOGY; FATIGUE; APNEA
AB To evaluate the relationship between physical activity with co morbidities and health-related quality of life in type 2 diabetic patients with and without restless legs syndrome (RLS). This is an observational study, set at tertiary care diabetic outpatient clinic, where 200 consecutive type 2 diabetic patients and 47 controls participated. Physical activity level was established by the International Physical Activity Questionnaire (IPAQ) and RLS diagnosis and RLS severity were established using the criteria defined by the International Restless Legs Syndrome Study Group; excessive daytime sleepiness was evaluated by the Epworth Sleepiness Scale, quality of sleep by the Pittsburgh Sleep Quality Index and Health-Related Quality of Life by the Short-Form Health Survey (SF-36). Depressive symptoms were investigated by Beck Depression Inventory (BDI- II). Among all diabetic patients (58 % women, mean age 52.7 +/- A 5.7), disease duration varied from 1 to 30 years (11.7 +/- A 7.5). Diabetic patients had more hypertension (76 %), peripheral neuropathy (65 %), and depressive symptoms (31 %) than controls; no gender differences were found between cases with and without depressive symptoms. RLS patients (72 % female) had worse quality of sleep. With regards to the quality of life domains, more active RLS diabetic patients had better perception of functional capacity, physical limitation, pain, and general health state (p < 0.05). RLS symptom severity did not vary according to physical activity (IPAQ level). This study shows that the physical activity is associated with a better perception of functional capacity, physical limitation, and pain in diabetic patients with RLS; thus a more active lifestyle should be encouraged.
C1 [da Costa Daniele, Thiago Medeiros; Sales de Bruin, Veralice Meireles; Costa e Forte, Adriana; Nobre de Oliveira, Debora Siqueira; Randal Pompeu, Clara Mota; Carvalhedo de Bruin, Pedro Felipe] Univ Fed Ceara, BR-60430270 Fortaleza, Ceara, Brazil.
C3 Universidade Federal do Ceara
RP Daniele, TMD (corresponding author), Univ Fed Ceara, R Cel Nunes de Melo 1315 Rodolfo Teofilo, BR-60430270 Fortaleza, Ceara, Brazil.
EM danielethiago@yahoo.com.br; veralice@superig.com.br;
   adrianaforti@uol.com.br; binha_nobre@hotmail.com; clara_mrp@hotmail.com;
   pedrobruin@gmail.com
RI ; CARVALHEDO DE BRUIN, PEDRO FELIPE/C-6056-2016
OI Daniele, Thiago Medeiros da Costa/0000-0003-1241-7068; CARVALHEDO DE
   BRUIN, PEDRO FELIPE/0000-0001-9694-1523
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NR 33
TC 22
Z9 24
U1 2
U2 27
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1355-008X
EI 1559-0100
J9 ENDOCRINE
JI Endocrine
PD AUG
PY 2013
VL 44
IS 1
BP 125
EP 131
DI 10.1007/s12020-012-9841-6
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 192KP
UT WOS:000322483500019
PM 23203003
DA 2025-06-11
ER

PT J
AU Ebrahimi, F
   Ghazimoradi, MM
   Fatima, G
   Bahramsoltani, R
AF Ebrahimi, Farnaz
   Ghazimoradi, Mohammad Mahdi
   Fatima, Ghizal
   Bahramsoltani, Roodabeh
TI Citrus flavonoids and adhesion molecules: Potential role in the
   management of atherosclerosis
SO HELIYON
LA English
DT Review
DE Atherosclerosis; Citrus; Flavonoid; Inflammation; Oxidative stress
ID AORTIC ENDOTHELIAL-CELLS; SCAVENGER RECEPTOR GENES; ESTER-INDUCED
   EXPRESSION; INDUCED OXIDATIVE STRESS; INFLAMMATION IN-VITRO; METABOLIC
   SYNDROME; OXIDIZED LDL; QUERCETIN; ANTIOXIDANT; NARINGIN
AB Atherosclerosis as a chronic inflammatory disorder is accompanied with oxidative stress which causes a high morbidity and mortality. Adhesion molecules, including intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), P-selectin, and E-selectin, are amongst the most important contributors in atherosclerosis. In such cases, dietary interventions with functional foods containing natural antioxidant and anti-inflammatory constituents are of a great interest. Citrus fruits are rich sources of flavonoids as natural pigments with potent antioxidant and anti-inflammatory activities. This study aims to review current evidence regarding the role of citrus flavonoids in the management of atherosclerosis with a focus on their effect on adhesion molecules. Electronic databases including PubMed, Scopus, and Web of Science were searched with the names of adhesion molecules and flavonoids from inception until January 2023. The included articles highly support the beneficial effects of citrus flavonoids in preclinical models of atherosclerosis. Quercetin, naringin and naringenin, hesperidin and hesperetin, nobiletin, rutin, luteolin, apigenin, and kaempferol are the most common flavonoids in citrus fruits which could modulate adhesion molecules including ICAM-1, VCAM-1, E-selectin, and P-selectin. Additionally, markers of chronic inflammation such as interleukins, tumor necrosis factor-alpha, nuclear factor-kappa B, and nitric oxide signaling, as well as oxidative stress markers like superoxide dismutase and glutathione were all normalized upon administration of citrus flavonoids. Conclusively, this review confirms the modulatory role of flavonoids on adhesion molecules in atherosclerosis based on the preclinical evaluations. Thus, citrus fruits can be further studied in atherosclerotic patients regarding their activity in reducing adhesion molecules.
C1 [Ebrahimi, Farnaz] Fac Pharm & Pharmaceut Sci, Dept Clin Pharm & Pharm Practice, Esfahan, Iran.
   [Ebrahimi, Farnaz] Universal Sci Educ & Res Network USERN, PhytoPharmacol Interest Grp PPIG, Esfahan, Iran.
   [Ghazimoradi, Mohammad Mahdi] Univ Tehran Med Sci, Fac Pharm, Tehran, Iran.
   [Fatima, Ghizal] Era Univ, Eras Lucknow Med Coll & Hosp, Lucknow, India.
   [Bahramsoltani, Roodabeh] Univ Tehran Med Sci, Sch Persian Med, Dept Tradit Pharm, Tehran, Iran.
   [Bahramsoltani, Roodabeh] 27 North Sarparast St,West Taleqani St,Felestine S, Tehran 1416663361, Iran.
C3 Universal Scientific Education & Research Network (USERN); Tehran
   University of Medical Sciences; Tehran University of Medical Sciences
RP Bahramsoltani, R (corresponding author), 27 North Sarparast St,West Taleqani St,Felestine S, Tehran 1416663361, Iran.
EM rbahramsoltani@sina.tums.ac.ir
RI Bahramsoltani, Roodabeh/A-1001-2018
OI Bahramsoltani, Roodabeh/0000-0001-6942-0546; Ghazimoradi, Mohammad
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NR 94
TC 15
Z9 18
U1 3
U2 11
PU CELL PRESS
PI CAMBRIDGE
PA 50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA
EI 2405-8440
J9 HELIYON
JI Heliyon
PD NOV
PY 2023
VL 9
IS 11
AR e21849
DI 10.1016/j.heliyon.2023.e21849
EA NOV 2023
PG 16
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA Z3GH5
UT WOS:001110985700001
PM 38028000
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Guan, RR
   Le, QV
   Yang, H
   Zhang, DQ
   Gu, HP
   Yang, YF
   Sonne, C
   Lam, SS
   Zhong, JT
   Jianguang, Z
   Liu, RQ
   Peng, WX
AF Guan, Ruirui
   Quyet Van Le
   Yang, Han
   Zhang, Dangquan
   Gu, Haiping
   Yang, Yafeng
   Sonne, Christian
   Lam, Su Shiung
   Zhong, Jiateng
   Jianguang, Zhu
   Liu, Runqiang
   Peng, Wanxi
TI A review of dietary phytochemicals and their relation to oxidative
   stress and human diseases
SO CHEMOSPHERE
LA English
DT Review
DE Diet; Phytochemicals; Health; Environment; Oxidative stress; Cancer
ID CARDIOVASCULAR RISK-FACTORS; BREAST-CANCER CELLS; IN-VITRO; ENDOTHELIAL
   DYSFUNCTION; PLANT STEROLS; INHIBITS ADIPOGENESIS; METABOLIC SYNDROME;
   MAMMALIAN LIGNANS; INDUCED OBESITY; FREE-RADICALS
AB Phytochemicals refer to active substances in plant-based diets. Phytochemicals found in for example fruits, vegetables, grains and seed oils are considered relatively safe for consumption due to mammalplant co-evolution and adaptation. A number of human diseases are related to oxidative stress caused by for example chemical environmental contaminants in air, water and food; while also lifestyle including smoking and lack of exercise and dietary preferences are important factors for disease development in humans. Here we explore the dietary sources of antioxidant phytochemicals that have beneficial effects on oxidative stress, cardiovascular and neurological diseases as well as cancer. Plantbased diets usually contain phenolic acids, flavonoids and carotenoids, which have strong antioxidant properties, and therefore remove the excess of active oxygen in the body, and protect cells from damage, reducing the risk of cardiovascular and Alzheimer's disease. In most cases, obesity is related to diet and inactivity and plant-based diets change lipid composition and metabolism, which reduce obesity related hazards. Cruciferous and Allium vegetables are rich in organic sulphides that can act on the metabolism of carcinogens and therefore used as anti-cancer and suppressing agents while dietary fibres and plant sterols may improve intestinal health and prevent intestinal diseases. Thus, we recommend a diet rich in fruits, vegetables, and grains as its content of phytochemicals may have the potential to prevent or improve a broad sweep of various diseases. (C) 2020 Elsevier Ltd. All rights reserved.
C1 [Guan, Ruirui; Yang, Han; Zhang, Dangquan; Gu, Haiping; Yang, Yafeng; Sonne, Christian; Lam, Su Shiung; Peng, Wanxi] Henan Agr Univ, Sch Forestry, Henan Prov Int Collaborat Lab Forest Resources Ut, Zhengzhou 450002, Peoples R China.
   [Quyet Van Le] Duy Tan Univ, Inst Res & Dev, Da Nang 550000, Vietnam.
   [Sonne, Christian] Aarhus Univ, Arctic Res Ctr ARC, Dept Biosci, Frederiksborgvej 399,POB 358, DK-4000 Roskilde, Denmark.
   [Lam, Su Shiung] Univ Malaysia Terengganu, Ctr Excellence HICoE, Inst Trop Aquaculture & Fisheries AKUATROP, Higher Inst, Terengganu 21030, Malaysia.
   [Zhong, Jiateng] Xinxiang Med Univ, Dept Pathol, Xinxiang 453003, Henan, Peoples R China.
   [Jianguang, Zhu] Henan Univ Tradit Chinese Med, Pharm Coll, Zhengzhou 450000, Peoples R China.
   [Liu, Runqiang] Henan Inst Sci & Technol, Sch Resources & Environm, Xinxiang 453003, Henan, Peoples R China.
C3 Henan Agricultural University; Duy Tan University; Aarhus University;
   Universiti Malaysia Terengganu; Xinxiang Medical University; Henan
   University of Traditional Chinese Medicine; Henan Institute of Science &
   Technology
RP Sonne, C; Peng, WX (corresponding author), Henan Agr Univ, Sch Forestry, Henan Prov Int Collaborat Lab Forest Resources Ut, Zhengzhou 450002, Peoples R China.
EM cs@bios.au.dk; pengwanxi@163.com
RI Van Le, Quyet/AAH-6385-2020; Wang, Zhibo/GSD-3371-2022; Zhong,
   Jiateng/AAB-2064-2022; LAM, SU SHIUNG/K-7436-2012; Sonne,
   Christian/I-7532-2013
OI LAM, SU SHIUNG/0000-0002-5318-1760; Yang, yafeng/0000-0003-1064-2982;
   Le, Quyet Van/0000-0002-4313-301X; Sonne, Christian/0000-0001-5723-5263;
   Zhang, Dangquan/0000-0002-3343-5428
FU Program for Innovative Research Team (in Science and Technology) in
   University of Henan Province [21IRTSTHN020]
FX The manuscript is supported by Program for Innovative Research Team (in
   Science and Technology) in University of Henan Province (No.
   21IRTSTHN020).
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NR 257
TC 101
Z9 106
U1 4
U2 92
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0045-6535
EI 1879-1298
J9 CHEMOSPHERE
JI Chemosphere
PD MAY
PY 2021
VL 271
AR 129499
DI 10.1016/j.chemosphere.2020.129499
EA JAN 2021
PG 14
WC Environmental Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology
GA RD4QJ
UT WOS:000633464400025
PM 33445014
DA 2025-06-11
ER

PT J
AU Nie, Q
   Zhu, LP
   Zhang, LJ
   Leng, B
   Wang, HX
AF Nie, Qu
   Zhu, Liping
   Zhang, Lijie
   Leng, Bin
   Wang, Hongxin
TI Astragaloside IV protects against hyperglycemia-induced vascular
   endothelial dysfunction by inhibiting oxidative stress and Calpain-1
   activation
SO LIFE SCIENCES
LA English
DT Article
DE Astragaloside IV; ROS; Calpain-1; Endothelial dysfunction; Oxidative
   stress; Diabetes
ID METABOLIC SYNDROME; ENOS; PHARMACOKINETICS; PATHOPHYSIOLOGY; INJECTION;
   EVENTS; RATS
AB Aims: Vascular endothelial cells act as a selective barrier between circulating blood and vessel wall and play an important role in the occurrence and development of cardiovascular diseases. Astragaloside IV (As-IV) has a protective effect on vascular endothelial cells, but its underlying mechanism remains unclear. This study is aimed at investigating the effect of As-IV on endothelial dysfunction (ED).
   Methods: Male Sprague Dawley (SD) were injected intraperitoneally with 65 mg/kg streptozotocin (STZ) to induce diabetes and then administered orally with As-IV (40, 80 mg/kg) for 8 weeks. Vascular function was evaluated by vascular reactivity in vivo and in vitro. The expression of calpain-1 and eNOS in the aorta of diabetic rats was examined by western blot. NO production was measured using nitrate reductase method. Oxidative stress was determined by measuring SOD, GSH-px and ROS.
   Results: Our results showed that As-IV administration significantly improved diabetes associated ED in vivo, and both NAC (an antioxidant) and MDL-28170 (calpain-1 inhibitor) significantly attenuated hyperglycemia-induced ED in vitro. Meanwhile, pretreatment with the inhibitor 1-NAME nearly abolished vasodilation to ACh in all groups of rats. Furthermore, As-IV increased NO production and the expression of eNOS in the thoracic aorta of diabetic rats. In addition, the levels of ROS were significantly increased, and the activity of SOD and GSH-px were decreased in diabetic rats, while As-IV administration reversed this change in a concentration-dependent manner.
   Conclusion: These results suggest that As-IV improves endothelial dysfunction in thoracic aortas from diabetic rats by reducing oxidative stress and calpain-1.
C1 [Nie, Qu; Zhu, Liping; Zhang, Lijie] Jinzhou Med Univ, Affiliated Hosp 1, Jinzhou 121001, Peoples R China.
   [Nie, Qu; Leng, Bin; Wang, Hongxin] Jinzhou Med Univ, Key Lab Cardiovasc & Cerebrovasc Drug Res Liaonin, Jinzhou 121001, Peoples R China.
C3 Jinzhou Medical University; Jinzhou Medical University
RP Wang, HX (corresponding author), Jinzhou Med Univ, Key Lab Cardiovasc & Cerebrovasc Drug Res Liaonin, Jinzhou 121001, Peoples R China.
EM hongxinwang@jzmu.edu.cn
RI Zhu, Li-Ping/AAF-7580-2020
OI Wang, Hongxin/0000-0002-3256-3137
FU National Natural Science Foundation of China [81673632, 81703739];
   Natural Science Foundation of Liaoning Province [2018 225026]; Liaoning
   Revitalization Talents Program [XLYC1802017]
FX This work was supported by the National Natural Science Foundation of
   China (Nos: 81673632 and 81703739), Natural Science Foundation of
   Liaoning Province (2018 225026) and Liaoning Revitalization Talents
   Program (No. XLYC1802017).
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NR 41
TC 45
Z9 52
U1 0
U2 20
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0024-3205
EI 1879-0631
J9 LIFE SCI
JI Life Sci.
PD SEP 1
PY 2019
VL 232
AR 116662
DI 10.1016/j.lfs.2019.116662
PG 8
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA IR7LT
UT WOS:000481623100009
PM 31323271
DA 2025-06-11
ER

PT J
AU Zhang, C
   Shao, ML
   Yang, H
   Chen, LM
   Yu, LC
   Cong, WT
   Tian, HS
   Zhang, FF
   Cheng, P
   Jin, LT
   Tan, Y
   Li, XK
   Cai, L
   Lu, XM
AF Zhang, Chi
   Shao, Minglong
   Yang, Hong
   Chen, Liangmiao
   Yu, Lechu
   Cong, Weitao
   Tian, Haishan
   Zhang, Fangfang
   Cheng, Peng
   Jin, Litai
   Tan, Yi
   Li, Xiaokun
   Cai, Lu
   Lu, Xuemian
TI Attenuation of Hyperlipidemia- and Diabetes-Induced Early-Stage
   Apoptosis and Late-Stage Renal Dysfunction via Administration of
   Fibroblast Growth Factor-21 Is Associated with Suppression of Renal
   Inflammation
SO PLOS ONE
LA English
DT Article
ID ACTIVATED PROTEIN-KINASE; CHRONIC KIDNEY-DISEASE; OXIDATIVE STRESS;
   FATTY-ACIDS; LIPID NEPHROTOXICITY; METABOLIC SYNDROME; SODIUM RETENTION;
   DB/DB MICE; KAPPA-B; NEPHROPATHY
AB Background: Lipotoxicity is a key feature of the pathogenesis of diabetic kidney disease, and is attributed to excessive lipid accumulation (hyperlipidemia). Increasing evidence suggests that fibroblast growth factor (FGF) 21 has a crucial role in lipid metabolism under diabetic conditions.
   Objective: The present study investigated whether FGF21 can prevent hyperlipidemia- or diabetes-induced renal damage, and if so, the possible mechanism.
   Methods: Mice were injected with free fatty acids (FFAs, 10 mg/10 g body weight) or streptozotocin (150 mg/kg) to establish a lipotoxic model or type 1 diabetic model, respectively. Simultaneously the mice were treated with FGF21 (100 mu g/kg) for 10 or 80 days. The kidney weight-to-tibia length ratio and renal function were assessed. Systematic and renal lipid levels were detected by ELISA and Oil Red O staining. Renal apoptosis was examined by TUNEL assay. Inflammation, oxidative stress, and fibrosis were assessed by Western blot.
   Results: Acute FFA administration and chronic diabetes were associated with lower kidney-to-tibia length ratio, higher lipid levels, severe renal apoptosis and renal dysfunction. Obvious inflammation, oxidative stress and fibrosis also observed in the kidney of both mice models. Deletion of the fgf21 gene further enhanced the above pathological changes, which were significantly prevented by administration of exogenous FGF21.
   Conclusion: These results suggest that FFA administration and diabetes induced renal damage, which was further enhanced in FGF21 knock-out mice. Administration of FGF21 significantly prevented both FFA- and diabetes-induced renal damage partially by decreasing renal lipid accumulation and suppressing inflammation, oxidative stress, and fibrosis.
C1 [Zhang, Chi; Shao, Minglong; Yu, Lechu; Cong, Weitao; Zhang, Fangfang; Cheng, Peng; Jin, Litai; Tan, Yi; Li, Xiaokun; Cai, Lu; Lu, Xuemian] Wenzhou Med Univ, Chinese Amer Res Inst Diabet Complicat, Wenzhou, Zhejiang, Peoples R China.
   [Zhang, Chi; Shao, Minglong; Yang, Hong; Chen, Liangmiao; Yu, Lechu; Zhang, Fangfang; Cheng, Peng; Tan, Yi; Cai, Lu; Lu, Xuemian] Wenzhou Med Univ, Chinese Amer Res Inst Diabet Complicat, Affiliated Hosp 3, Ruian Ctr, Wenzhou, Zhejiang, Peoples R China.
   [Shao, Minglong; Cong, Weitao; Tian, Haishan; Jin, Litai; Li, Xiaokun] Wenzhou Med Univ, Sch Pharm, Wenzhou, Zhejiang, Peoples R China.
   [Tan, Yi; Cai, Lu] Univ Louisville, Dept Pediat, Kosair Childrens Hosp, Res Inst, Louisville, KY 40292 USA.
C3 Wenzhou Medical University; Wenzhou Medical University; Wenzhou Medical
   University; University of Louisville
RP Cai, L (corresponding author), Wenzhou Med Univ, Chinese Amer Res Inst Diabet Complicat, Wenzhou, Zhejiang, Peoples R China.
EM lu89118@medmail.com.cn; lu.cai@louisville.edu
RI Wang, Yinglong/AGE-0348-2022; Cai, Lu/AAG-9920-2019; Zhang,
   Fangfang/ADK-4823-2022; Cheng, Peng/R-6211-2016
FU National Science Foundation of China [81370917, 81000294]; Wenzhou
   Medical University [QTJ13005]; China-Canada Joint Health Research
   Initiative [81061120517]; Starting-Up Fund for Chinese-American Research
   Institute for Diabetic Complications from Wenzhou Medical University
FX This study was supported in part by a Young Scientist Award from
   National Science Foundation of China (81000294 to CZ), National Science
   Foundation of China (81370917 to CZ), Research Development Fund of
   Wenzhou Medical University (QTJ13005 to CZ), China-Canada Joint Health
   Research Initiative (81061120517 to SC and XL) and a Starting-Up Fund
   for Chinese-American Research Institute for Diabetic Complications from
   Wenzhou Medical University (to XL and LC). The funders had no role in
   study design, data collection and analysis, decision to publish, or
   preparation of the manuscript.
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NR 62
TC 75
Z9 82
U1 2
U2 18
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD DEC 9
PY 2013
VL 8
IS 12
AR e82275
DI 10.1371/journal.pone.0082275
PG 11
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 275VD
UT WOS:000328705200069
PM 24349242
OA gold, Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Ferguson, JJA
   Oldmeadow, C
   Bentley, D
   Garg, ML
AF Ferguson, Jessica J. A.
   Oldmeadow, Christopher
   Bentley, David
   Garg, Manohar L.
TI Antioxidant Effects of a Polyphenol-Rich Dietary Supplement
   Incorporating Pinus massoniana Bark Extract in Healthy Older
   Adults: A Two-Arm, Parallel Group, Randomized Placebo-Controlled Trial
SO ANTIOXIDANTS
LA English
DT Article
DE ageing; pine bark; proanthocyanidins; antioxidants; polyphenols;
   oxidative stress
ID METABOLIC SYNDROME; FREE-RADICALS; PROANTHOCYANIDINS; MALONDIALDEHYDE;
   PYCNOGENOL(R); PREVENTION; FIBRINOGEN; INCREASES; CAPACITY; PROTEIN
AB Oxidative stress is a key physiological phenomenon underpinning the ageing process and plays a major developmental role in age-associated chronic diseases. This study investigated the antioxidant effects of a polyphenol-rich dietary supplement containing Pinus massoniana bark extract (PMBE) in healthy older adults. In a double-blinded, placebo-controlled clinical trial, participants were randomised (in a 1:1 ratio) to receive a 50 mL/day dietary supplement containing placebo (0 mg PMBE) or PMBE (1322 mg PMBE) for 12 weeks. The primary outcome was fasting plasma malondialdehyde (MDA) concentrations and secondary outcomes were plasma inflammatory markers. MDA concentrations significantly reduced following PMBE for 6 weeks (-1.19 nmol/mL, 95%CI -1.62, -0.75, p < 0.001) and 12 weeks (-1.35 nmol/mL, 95%CI -1.74, -0.96, p < 0.001) compared to baseline. MDA did not significantly change after the placebo. MDA levels at 6 and 12 weeks were significantly lower following PMBE compared to placebo (p < 0.001). At 12 weeks in the PMBE group, fibrinogen concentrations significantly reduced (-0.25 g/L, 95%CI -0.39, -0.11; p < 0.0001) and interleukin-6 significantly increased compared to placebo (0.30 pg/mL, 95%CI 0.02, 0.59; p < 0.05). PMBE in a polyphenol-rich dietary supplement reduced oxidative stress in healthy older adults. Further studies are warranted to investigate the antioxidant capacity of PMBE in conditions with heightened oxidative stress, such as osteoarthritis, hypertension, type 2 diabetes, or other lifestyle related diseases.
C1 [Ferguson, Jessica J. A.; Garg, Manohar L.] Univ Newcastle, Sch Biomed Sci & Pharm, Nutraceut Res Program, Callaghan, NSW 2308, Australia.
   [Oldmeadow, Christopher] Univ Newcastle, Clin Res Design, Informat Technol & Stat Support Unit, Hunter Med Res Inst, New Lambton, NSW 2308, Australia.
   [Bentley, David] Univ Newcastle, Sch Life & Environm Sci, Ourimbah, NSW 2258, Australia.
C3 University of Newcastle; Hunter Medical Research Institute; University
   of Newcastle; University of Newcastle
RP Garg, ML (corresponding author), Univ Newcastle, Sch Biomed Sci & Pharm, Nutraceut Res Program, Callaghan, NSW 2308, Australia.
EM manohar.garg@newcastle.edu.au
RI Ferguson, Jessica/ABC-2840-2021; Oldmeadow, Chris/HKF-3685-2023
OI Garg, Manohar/0000-0003-0514-0865; Ferguson,
   Jessica/0000-0002-7962-1840; Oldmeadow, Christopher/0000-0001-6104-1322;
   Bentley, David/0000-0002-0390-7308
FU Tismor Health and Wellness [G2000808]; Hunter Medical Research Institute
   [G2101041]
FX This research was funded by Tismor Health and Wellness (G2000808).
   J.J.A.F. was the recipient of a bridging scholarship and an Early Career
   small grant for statistical support (G2101041) from the Hunter Medical
   Research Institute during the conduct of this work.
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NR 63
TC 2
Z9 2
U1 2
U2 6
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD AUG
PY 2022
VL 11
IS 8
AR 1560
DI 10.3390/antiox11081560
PG 16
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA 4C3EZ
UT WOS:000846342600001
PM 36009279
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Yao, B
   Lv, JL
   Du, L
   Zhang, H
   Xu, Z
AF Yao, Bo
   Lv, Junlin
   Du, Le
   Zhang, Hui
   Xu, Zhao
TI Phoenixin-14 protects cardiac damages in a streptozotocin-induced
   diabetes mice model through SIRT3
SO ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
LA English
DT Article
DE Diabetic cardiomyopathy; cardiac hypertrophy; Phoenixin-14; oxidative
   stress; SIRT3
ID OXIDATIVE STRESS; MOUSE MODEL; HYPERTROPHY; CARDIOMYOPATHY; OXYGEN;
   DYSFUNCTION; MECHANISMS; DEGENERATION; INFLAMMATION; FIBROSIS
AB Background Type I diabetes is a metabolic syndrome that severely impacts the normal lives of patients through its multiple complications, such as diabetic cardiomyopathy (DCM). Phoenixin-14 is a peptide found to be widely expressed in eukaryons with multiple protective properties, including anti-oxidative stress and anti-inflammatory effects. The present study aims to explore the potential therapeutic impacts of Phoenixin-14 on DCM. Methods Type I diabetes was induced by treatment with a single dose of STZ (40 mg/kg body weight) intraperitoneally for 5 consecutive days. Mice were divided into four groups: the Control, Phoenixin-14, T1DM, and Phoenixin-14 +T1DM groups. The levels of myocardial injury markers were measured. Cardiac hypertrophy was assessed using wheat germ agglutinin (WGA) staining. Results Phoenixin-14 was significantly downregulated in the cardiac tissue of diabetic mice. The myocardial injury and deteriorated cardiac function in diabetic mice induced by STZ were significantly ameliorated by Phoenixin-14, accompanied by the alleviation of cardiac hypertrophy. In addition, the severe oxidative stress and inflammation in diabetic mice were dramatically mitigated by Phoenixin-14. Lastly, the downregulated SIRT3 and upregulated p-FOXO3 in diabetic mice were pronouncedly reversed by Phoenixin-14. It is worth mentioning that compared to the Control, no significant changes to any of the investigated parameters in the present study were found in the Phoenixin-14-treated normal mice, suggesting that treatment with it has no side effects. Conclusion Our data revealed that Phoenixin-14 protected against cardiac damages in STZ-induced diabetes mice models.
C1 [Yao, Bo; Du, Le; Zhang, Hui; Xu, Zhao] Xi An Jiao Tong Univ, Med Coll, Affiliated Hosp 3, Dept Anesthesiol,Shaanxi Prov Peoples Hosp, 256 You Yi Rd, Xian 710068, Shaanxi, Peoples R China.
   [Lv, Junlin] Xi An Jiao Tong Univ, Med Coll, Affiliated Hosp 2, Dept Anesthesiol, Xian, Shaanxi, Peoples R China.
C3 Xi'an Jiaotong University; Xi'an Medical University; Xi'an Jiaotong
   University
RP Xu, Z (corresponding author), Xi An Jiao Tong Univ, Med Coll, Affiliated Hosp 3, Dept Anesthesiol,Shaanxi Prov Peoples Hosp, 256 You Yi Rd, Xian 710068, Shaanxi, Peoples R China.
EM xu_zhao996@126.com
RI Yao, Bowen/LVS-4612-2024
FU "Xi'an Jiaotong University
FX This study is funded by "Xi'an Jiaotong University."
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NR 40
TC 10
Z9 11
U1 3
U2 16
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1381-3455
EI 1744-4160
J9 ARCH PHYSIOL BIOCHEM
JI Arch. Physiol. Biochem.
PD JAN 2
PY 2024
VL 130
IS 1
BP 110
EP 118
DI 10.1080/13813455.2021.1981946
EA OCT 2021
PG 9
WC Biochemistry & Molecular Biology; Biophysics; Endocrinology &
   Metabolism; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Endocrinology &
   Metabolism; Physiology
GA GS7P1
UT WOS:000704564600001
PM 34618648
DA 2025-06-11
ER

PT J
AU Park, CH
   Kim, DH
   Park, MH
   Kim, MK
   Kim, ND
   Kim, CM
   Tanaka, T
   Yokozawa, T
   Chung, HY
   Moon, HR
AF Park, Chan Hum
   Kim, Dae Hyun
   Park, Min Hi
   Kim, Mi Kyung
   Kim, Nam Deuk
   Kim, Cheol Min
   Tanaka, Takashi
   Yokozawa, Takako
   Chung, Hae Young
   Moon, Hyung Ryong
TI Chinese Prescription Kangen-karyu and Salviae Miltiorrhizae Radix
   Improve Age-Related Oxidative Stress and Inflammatory Response through
   the PI3K/Akt or MAPK Pathways
SO AMERICAN JOURNAL OF CHINESE MEDICINE
LA English
DT Article
DE Kangen-karyu; Salviae Miltiorrhizae Radix; Aging; Renal Damage; Insulin
   Resistance; Oxidative Stress; Inflammation
ID NF-KAPPA-B; METABOLIC SYNDROME; DIABETIC-NEPHROPATHY; PROTECTIVE ROLE;
   MOUSE MODEL; EXPRESSION; ACTIVATION; RECEPTOR; KIDNEY; GLUTATHIONE
AB This study examined whether Kangen-karyu and its crude drug, Salviae Miltiorrhizae Radix, have a reno-protective effect on the age-related oxidative stress and inflammatory response through the phosphoinositide 3-kinase (PI3K)/Akt or mitogen-activated protein kinase (MAPK) pathways in aged rats. Kangen-karyu or Salviae Miltiorrhizae Radix (20 mg/kg body weight/day) was administered orally to old groups of rats for 16 days, and their effects were compared with the vehicle-treated old and young rats. The administration of Kangen-karyu caused a slight decrease in the serum glucose level and a significant decrease in the serum insulin level in the old rats. The increased levels of serum renal functional parameter (urea-nitrogen) and oxidative parameter were significantly reduced by both Kangen-karyu and Salviae Miltiorrhizae Radix. The old rats exhibited a dysregulation of the protein expression related to insulin resistance, oxidative stress, and inflammation in the kidneys, but Kangen-karyu administration significantly reduced the expression of the inflammatory proteins through the PI3K/Akt pathway. On the other hand, the Salviae Miltiorrhizae Radix-treated old rats showed a decrease in the inflammatory cytokines through the MAPK pathway. These results provide important evidence that Kangen-karyu and Salviae Miltiorrhizae Radix have a pleiotropic effect on the PI3K/Akt and MAPK pathways, showing renoprotective effects against the development of inflammation in old rats. This study provides scientific evidence that Kangen-karyu and Salviae Miltiorrhizae Radix improve the inflammatory responses via the PI3K/Akt or MAPK pathways in the kidney of old rats.
C1 [Park, Chan Hum; Kim, Dae Hyun; Park, Min Hi; Kim, Nam Deuk; Yokozawa, Takako; Chung, Hae Young; Moon, Hyung Ryong] Pusan Natl Univ, Mol Inflammat Res Ctr Aging Intervent MRCA, Pusan 609735, South Korea.
   [Kim, Mi Kyung; Kim, Nam Deuk; Kim, Cheol Min] Pusan Natl Univ, Res Ctr Antiaging Technol Dev, Pusan 609735, South Korea.
   [Tanaka, Takashi] Nagasaki Univ, Grad Sch Biomed Sci, Nagasaki 8528521, Japan.
   [Yokozawa, Takako] Toyama Univ, Grad Sch Sci & Engn Res, Toyama 9308555, Japan.
C3 Pusan National University; Pusan National University; Nagasaki
   University; University of Toyama
RP Chung, HY (corresponding author), Pusan Natl Univ, Coll Pharm, Mol Inflammat Res Ctr Aging Intervent MRCA, Pusan 609735, South Korea.
EM hyjung@pusan.ac.kr; mhr108@pusan.ac.kr
RI Park, Min/AAL-9880-2020; KIM, Hyeon-Joong/C-4448-2011; Kim,
   Sunyoung/ABH-5075-2020
OI Tanaka, Takashi/0000-0001-7762-7432
FU Cooperative Research Program for Agriculture Science & Technology
   Development Rural Development Administration, Republic of Korea
   [PJ00652213]; MRC program of the Medical Research Center program of the
   National Research Foundation of Korea [2009-0083538]; R&D program of
   MKE/KEIT (Development of Functional Food Materials and Device for
   prevention of Aging-associated Muscle Function Decrease) [10040391];
   Post-doc Development Program of Pusan National University
FX This work was carried out with the support of the "Cooperative Research
   Program for Agriculture Science & Technology Development (Project No.
   PJ00652213)" Rural Development Administration, Republic of Korea. This
   work was also supported by The MRC program (NO. 2009-0083538) of the
   Medical Research Center program of the National Research Foundation of
   Korea and the R&D program of MKE/KEIT (10040391, Development of
   Functional Food Materials and Device for prevention of Aging-associated
   Muscle Function Decrease). We also take this opportunity to thank the
   Aging Tissue Bank (Busan, Korea) for supplying research materials. This
   study was financially supported by the 2013 Post-doc Development Program
   of Pusan National University.
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NR 58
TC 19
Z9 20
U1 0
U2 4
PU WORLD SCIENTIFIC PUBL CO PTE LTD
PI SINGAPORE
PA 5 TOH TUCK LINK, SINGAPORE 596224, SINGAPORE
SN 0192-415X
EI 1793-6853
J9 AM J CHINESE MED
JI Am. J. Chin. Med.
PY 2014
VL 42
IS 4
BP 987
EP 1005
DI 10.1142/S0192415X14500621
PG 19
WC Integrative & Complementary Medicine; Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine; General & Internal Medicine
GA AM2BL
UT WOS:000339653000014
PM 25004887
DA 2025-06-11
ER

PT J
AU Agrawal, NK
   Maiti, R
   Dash, D
   Pandey, BL
AF Agrawal, Neeraj K.
   Maiti, Rituparna
   Dash, D.
   Pandey, B. L.
TI Cilostazol reduces inflammatory burden and oxidative stress in
   hypertensive type 2 diabetes mellitus patients
SO PHARMACOLOGICAL RESEARCH
LA English
DT Article
DE atherosclerosis; inflammation; oxidative stress; type 2 diabetes
   mellitus; cilostazol
ID C-REACTIVE PROTEIN; BLOOD-CELL COUNT; ATHEROSCLEROSIS RISK; GLYCATED
   HEMOGLOBIN; METABOLIC SYNDROME; LEUKOCYTE COUNT; KAPPA-B; DISEASE;
   ADHESION; ASSOCIATION
AB Objectives: Inflammation and oxidative stress cause genesis and progression of atherosclerosis in diabetes. This study aimed to assess effects of Cilostazol on these factors in hypertensive type 2 diabetic patients.
   Materials and methods: In randomized, open, add-on preventive controlled clinical trial design, 60 hypertensive type 2 diabetics aged >= 45 years were evaluated clinically and for total leukocyte count, erythrocyte sedimentation rate, serum albumin, serum hsC-reactive protein, plasma malondialdehyde, blood reduced glutathione and HbA1c levels. After informed consent, 30 patients received Cilostazol (100mg) twice daily orally as add-on therapy. At 1 month follow-up, 26 patients in control group and 22 patients in Cilostazol group completed the trial and particular parameters were re-evaluated.
   Results: The mean age and duration of diabetes were 55 7 years and 8 6 years, respectively. At follow-up, the Cilostazol group showed significant (p < 0.001) decrease in hsC-reactive protein (23.6%), erythrocyte sedimentation rate (38.7%), total leukocyte count (12.6%), plasma malondialdehyde (17.6%), HbA1c (0.17%,p=0.002) and increase in serum albumin (11.9%), blood reduced glutathione (3.5%) from baseline. UKPDS 10 years risk of coronary heart disease decreased by 6% (p = 0.002). The control group did not show significant improvement in inflammatory profile, oxidative status and HbA1c.
   Conclusion: Inflammatory and oxidative stress is high in hypertensive type 2 diabetic patients. Cilostazol reduces these factors as well as coronary heart disease risk in diabetes mellitus. (c) 2007 Elsevier Ltd. All rights reserved.
C1 Banaras Hindu Univ, Inst Med Sci, Dept Endocrinol & Metab, Varanasi 221005, Uttar Pradesh, India.
   Banaras Hindu Univ, Dept Pharmacol, Inst Med Sci, Varanasi 221005, Uttar Pradesh, India.
   Banaras Hindu Univ, Dept Biochem, Inst Med Sci, Varanasi 221005, Uttar Pradesh, India.
C3 Banaras Hindu University (BHU); Banaras Hindu University (BHU); Banaras
   Hindu University (BHU)
RP Agrawal, NK (corresponding author), Banaras Hindu Univ, Inst Med Sci, Dept Endocrinol & Metab, Varanasi 221005, Uttar Pradesh, India.
EM drnkavns@gmail.com; rituparnamaiti@rediffmail.com; ddass@satyam.net.in
RI MAITI, RITUPARNA/MFI-2945-2025; DASH, DEBABRATA/AAF-1837-2020; Agrawal,
   NK/H-8653-2013
OI Agrawal, NK/0000-0001-7322-4134; MAITI, RITUPARNA/0000-0003-4063-9178;
   DASH, DEBABRATA/0009-0008-3595-8928
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NR 36
TC 48
Z9 51
U1 0
U2 7
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 1043-6618
J9 PHARMACOL RES
JI Pharmacol. Res.
PD AUG
PY 2007
VL 56
IS 2
BP 118
EP 123
DI 10.1016/j.phrs.2007.04.007
PG 6
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 217JB
UT WOS:000249943100004
PM 17548203
DA 2025-06-11
ER

PT J
AU Zhang, AL
   Balmes, JR
   Lutzker, L
   Mann, JK
   Margolis, HG
   Tyner, T
   Holland, N
   Noth, EM
   Lurmann, F
   Hammond, SK
   Holm, SM
AF Zhang, Amy L.
   Balmes, John R.
   Lutzker, Liza
   Mann, Jennifer K.
   Margolis, Helene G.
   Tyner, Tim
   Holland, Nina
   Noth, Elizabeth M.
   Lurmann, Fred
   Hammond, S. Katharine
   Holm, Stephanie M.
TI Traffic-related air pollution, biomarkers of metabolic dysfunction,
   oxidative stress, and CC16 in children
SO JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY
LA English
DT Article
DE Traffic-related Air Pollution; Early Life Childhood Exposure; Oxidative
   Stress; Metabolic Dysregulation; Polycyclic Aromatic Hydrocarbons;
   Low-SES Populations
ID PARTICULATE MATTER; INSULIN-RESISTANCE; EXHALED BREATH; BLOOD-PRESSURE;
   INFLAMMATION; EXPOSURE; ATHEROSCLEROSIS; 8-ISOPROSTANE; ASSOCIATIONS;
   PREVALENCE
AB Background Previous research has revealed links between air pollution exposure and metabolic syndrome in adults; however, these associations are less explored in children. Objective This study aims to investigate the association between traffic-related air pollutants (TRAP) and biomarkers of metabolic dysregulation, oxidative stress, and lung epithelial damage in children. Methods We conducted cross-sectional analyses in a sample of predominantly Latinx, low-income children (n = 218) to examine associations between air pollutants (nitrogen dioxide (NO2), nitrogen oxides (NOx), elemental carbon, polycyclic aromatic hydrocarbons, carbon monoxide (CO), fine particulates (PM2.5)) and biomarkers of metabolic function (high-density lipoprotein (HDL), hemoglobin A1c (HbA1c), oxidative stress (8-isoprostane), and lung epithelial damage (club cell protein 16 (CC16)). Results HDL cholesterol showed an inverse association with NO2 and NOx, with the strongest relationship between HDL and 3-month exposure to NO2 (-15.4 mg/dL per IQR increase in 3-month NO2, 95% CI = -27.4, -3.4). 8-isoprostane showed a consistent pattern of increasing values with 1-day and 1-week exposure across all pollutants. Non-significant increases in % HbA1c were found during 1-month time frames and decreasing CC16 in 3-month exposure time frames. Conclusion Our results suggest that TRAP is significantly associated with decreased HDL cholesterol in longer-term time frames and elevated 8-isoprostane in shorter-term time frames. TRAP could have the potential to influence lifelong metabolic patterns, through metabolic effects in childhood.
C1 [Zhang, Amy L.; Balmes, John R.; Lutzker, Liza; Mann, Jennifer K.; Holland, Nina; Noth, Elizabeth M.; Hammond, S. Katharine; Holm, Stephanie M.] Univ Calif Berkeley, Sch Publ Hlth, Div Environm Hlth Sci, Berkeley, CA 94720 USA.
   [Balmes, John R.; Holm, Stephanie M.] Western States Pediat Environm Hlth Specialty Uni, San Francisco, CA 94103 USA.
   [Balmes, John R.; Holm, Stephanie M.] Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA.
   [Margolis, Helene G.] Univ Calif Davis, Dept Internal Med, Davis, CA 95616 USA.
   [Tyner, Tim] Univ Calif San Francisco, San Francisco, CA 94143 USA.
   [Tyner, Tim] Cent Calif Asthma Collaborat, Fresno, CA USA.
   [Lurmann, Fred] Sonoma Technol, Petaluma, CA USA.
C3 University of California System; University of California Berkeley;
   University of California System; University of California San Francisco;
   University of California System; University of California Davis;
   University of California System; University of California San Francisco;
   Sonoma Technology, Inc.
RP Holm, SM (corresponding author), Univ Calif Berkeley, Sch Publ Hlth, Div Environm Hlth Sci, Berkeley, CA 94720 USA.; Holm, SM (corresponding author), Western States Pediat Environm Hlth Specialty Uni, San Francisco, CA 94103 USA.; Holm, SM (corresponding author), Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA.
EM stephaniemholm@berkeley.edu
RI Holm, Stephanie/AAC-7456-2020; Lutzker, Liza/MAI-3669-2025; Balmes,
   John/L-6281-2019
OI Zhang, Amy/0000-0001-7541-2403
FU Children's Health and Air Pollution Study (CHAPS); NIH/EPA [EPA:
   RD83543501, NIH: ES022849, NIH: R24 ES030888, NIH: R33 ES024719];
   National Institute for Occupational Safety and Health [T42OH008429]
   Funding Source: NIH RePORTER; National Institute of Environmental Health
   Sciences [R24ES030888] Funding Source: NIH RePORTER
FX This research was supported by the Children's Health and Air Pollution
   Study (CHAPS), an NIH/EPA-funded Children's Environmental Health
   Research Center (EPA: RD83543501, NIH: ES022849) and two additional
   grants (NIH: R24 ES030888 and NIH: R33 ES024719). The content is solely
   the responsibility of the authors and does not necessarily represent the
   official views of the National Institutes of Health.
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NR 53
TC 22
Z9 22
U1 1
U2 13
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 1559-0631
EI 1559-064X
J9 J EXPO SCI ENV EPID
JI J. Expo. Sci. Environ. Epidemiol.
PD JUL
PY 2022
VL 32
IS 4
BP 530
EP 537
DI 10.1038/s41370-021-00378-6
EA AUG 2021
PG 8
WC Environmental Sciences; Public, Environmental & Occupational Health;
   Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health; Toxicology
GA 3M8QH
UT WOS:000686862100001
PM 34417545
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Leisegang, K
   Henkel, R
   Agarwal, A
AF Leisegang, Kristian
   Henkel, Ralf
   Agarwal, Ashok
TI Redox Regulation of Fertility in Aging Male and the Role of
   Antioxidants: A Savior or Stressor
SO CURRENT PHARMACEUTICAL DESIGN
LA English
DT Review
DE Oxidative stress; reactive oxygen species; antioxidants; aging males;
   male infertility; redox balance
ID MITOCHONDRIAL OXIDATIVE STRESS; FREE-RADICAL THEORY; MALE-INFERTILITY;
   LIPID-PEROXIDATION; METABOLIC SYNDROME; SPERM QUALITY; SEMEN QUALITY;
   REPRODUCTIVE FUNCTION; ERECTILE FUNCTION; REDUCTIVE STRESS
AB Oxidative stress (OS), an imbalance between reactive oxygen species (ROS) and antioxidant scavengers, is considered an important underlying mechanism associated with ageing, age-related chronic diseases and reproductive decline in males. However, OS is an important regulator of numerous molecular pathways essential for homeostasis within cells, tissues and systems. A fine balance between factors promoting OS and those that scavenge ROS is critically important. In the male reproductive tract and ejaculate, ROS are critical molecular players in essential reproductive processes, including spermatogenesis, epididymal transport, spermatozoa maturation and post-ejaculation processes such as motility, capacitation and the acrosome reaction. Increasing evidence suggests there is an overlap between age-related OS and male reproductive tract dysfunction correlating with reduced fertility potential due to semen quality decline, endocrine changes and sexual dysfunction. With increasing life expectancy in many regions of the world, together with an increasing paternal age and associated risk of for infertility, pregnancy complications and reduced health potential in the offspring, it is becoming increasingly important to fully understand the mechanism linked with these associations. This review considers the role of ROS and OS in fertility regulation, the ageing process, the role for OS in age-related reproductive decline, the approach to assessment in male infertility and the current use of antioxidants as a therapeutic option. Although evidence suggests exogenous antioxidant supplementation is useful in male infertility, caution to excessive or unnecessary use of these approaches is required to avoid the paradox of antioxidants inhibiting essential and beneficial ROS activities in male reproductive biology.
C1 [Leisegang, Kristian] Univ Western Cape, Sch Nat Med, Private Bag X17, ZA-7535 Bellville, South Africa.
   [Henkel, Ralf] Univ Western Cape, Dept Med Biosci, Private Bag X17, ZA-7535 Bellville, South Africa.
   [Agarwal, Ashok] Cleveland Clin, Amer Ctr Reprod Med, Cleveland, OH 44195 USA.
C3 University of the Western Cape; University of the Western Cape;
   Cleveland Clinic Foundation
RP Henkel, R (corresponding author), Univ Western Cape, Dept Med Biosci, Private Bag X17, ZA-7535 Bellville, South Africa.
EM rhenkel@uwc.ac.za
RI Leisegang, Kristian/AAS-3925-2021
OI Leisegang, Kristian/0000-0002-3003-8048; Henkel,
   Ralf/0000-0003-1128-2982
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NR 134
TC 40
Z9 40
U1 0
U2 7
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1381-6128
EI 1873-4286
J9 CURR PHARM DESIGN
JI Curr. Pharm. Design
PY 2017
VL 23
IS 30
BP 4438
EP 4450
DI 10.2174/1381612822666161019150241
PG 13
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA FO5VK
UT WOS:000416929300003
PM 27774895
DA 2025-06-11
ER

PT J
AU Gomez-Parra, M
   Romero-Arrieta, L
   Vasquez-Trespalacios, EM
   Palacio-Jaramillo, V
   Valencia-Martinez, A
AF Gomez-Parra, Myrna
   Romero-Arrieta, Lydis
   Maria Vasquez-Trespalacios, Elsa
   Palacio-Jaramillo, Veronica
   Valencia-Martinez, Andrea
TI Association between shift work and being overweight or obese among
   health care workers in a clinical setting in Medellin, Colombia
SO WORK-A JOURNAL OF PREVENTION ASSESSMENT & REHABILITATION
LA English
DT Article
DE Working-time arrangements; body mass index; stress; weight; waist to hip
   ratio
ID BODY-MASS INDEX; CORONARY-HEART-DISEASE; METABOLIC SYNDROME;
   CARDIOVASCULAR RISK; WEIGHT-GAIN; NIGHT WORK; JOB STRAIN; NURSES;
   PREVALENCE; STRESS
AB BACKGROUND: Shift work is common in health care settings and has been hypothesized as a risk factor for being overweight or obese. We examined the relation between shift work and being overweight or obese, adjusting for stress and lifestyle habits in Colombian health care workers.
   OBJECTIVE: The aim of this study was to assess the association between shift work and being overweight/obese in employees of a health care setting in Medellin, Colombia.
   METHODS: This cross-sectional study was carried out among 200 workers in a health care setting. Participants completed a demographic, occupational, work-related stress and life style questionnaire. Their Body Mass Index (BMI) and waist to hip ratio were also measured.
   RESULTS: The study sample consisted of 160 (80%) females and 40 (20%) males. Mean age was 35.1 +/- 9.1 years and mean BMI was 25 +/- 3.9. After adjusting for potential confounders, multivariate logistic regression revealed no statistically significant association between being overweight, being obese or waist to hip ratio and shift work; 95% CI OR: 1.08 (0.62-1.89), 1.33 (0.44-3.99) and 1.2 (0.8-1.9), respectively. Day workers were statistically more likely to smoke, work more hours, and have a higher educational level than shift workers.
   CONCLUSIONS: No significant associations between shift work and being overweight/obese were observed in health care workers in a Colombian setting. These findings need to be confirmed through longitudinal studies.
C1 [Gomez-Parra, Myrna] Sura, Hlth Care, Medellin, Colombia.
   [Romero-Arrieta, Lydis] Dinamica, Hlth Care, Medellin, Colombia.
   [Maria Vasquez-Trespalacios, Elsa; Palacio-Jaramillo, Veronica; Valencia-Martinez, Andrea] CES Univ, Publ Hlth Observ, Medellin, Colombia.
RP Vasquez-Trespalacios, EM (corresponding author), Calle 10A 22-04, Medellin, Colombia.
EM evasquez@ces.edu.co
OI Vasquez-Trespalacios, Elsa Maria/0000-0002-0665-5310
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NR 62
TC 16
Z9 18
U1 0
U2 10
PU IOS PRESS
PI AMSTERDAM
PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS
SN 1051-9815
EI 1875-9270
J9 WORK
JI Work
PY 2016
VL 55
IS 3
BP 635
EP 642
DI 10.3233/WOR-162438
PG 8
WC Public, Environmental & Occupational Health
WE Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA EC6DP
UT WOS:000388227000016
PM 27792036
DA 2025-06-11
ER

PT J
AU Carnicer, R
   Guillén, N
   Arbonés-Mainar, JM
   Navarro, MA
   Guzmán, MA
   Barranquero, C
   Arnal, C
   Gascón, S
   Acín, S
   Mourelle, M
   Osada, J
AF Carnicer, Ricardo
   Guillen, Natalia
   Arbones-Mainar, Jose M.
   Navarro, Maria A.
   Guzman, Mario A.
   Barranquero, Cristina
   Arnal, Carmen
   Gascon, Sonia
   Acin, Sergio
   Mourelle, Marisabel
   Osada, Jesus
TI Nitric oxide-releasing agent, LA419, reduces atherogenesis in
   apolipoprotein E-deficient mice
SO NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
LA English
DT Article
DE Cholesterol; Apolipoprotein; Atherosclerosis; NO; LA419
ID E KNOCKOUT MICE; ATHEROSCLEROTIC LESION DEVELOPMENT; LDL
   RECEPTOR-DEFICIENT; LINOLEIC-ACID ISOMERS; VIRGIN OLIVE OILS;
   BRACHIOCEPHALIC ARTERY; SYNTHASE PATHWAY; OXIDATIVE STRESS; DONOR
   LA-419; AORTIC ROOT
AB LA419 is a novel nitric oxide-donor with antioxidant properties. The effect of this compound on the development of atherosclerosis was investigated in apolipoprotein E-deficient mice. Male mice were randomized to receive vehicle or 5 mg/kg/day LA419 for 12 weeks. At the end of this period, plasma lipid and lipoprotein parameters, oxidative stress markers and hepatic fat, and mRNA levels were measured as well as en face and cross-sectional lesion areas of the aorta. Data showed that LA419 administration reduced atherosclerotic foci and cross-sectional lesion areas by decreasing the intimae presence of macrophage-derived foam cells despite an increase in plasma cholesterol. This agent induced a significant reduction in body weight gain and mass of adipose tissue. Furthermore, compared with placebo, LA419 administration significantly reduced plasma triglycerides and apolipoprotein C-III levels as well as systemic oxidative stress, estimated by plasma 8-isoprostane. Conversely, nonesterified fatty acid and HDL cholesterol levels remained unchanged, as well as apolipoproteins A-I, A-IV, and B and paraoxonase activity. Plasma triglycerides were significantly associated with plasma levels of apolipoprotein C-III and hepatic Fsp27 mRNA expression. These results indicate that administration of LA419 modulates lesion development. These actions are partly independent of total cholesterol as well as HDL particles and related to triglyceridemia and oxidative stress. Hypotriglyceridemia is associated with an equal number of apoB-containing particles. Hence, LA419 administration could be used as a safe alternative to control the metabolic syndrome and atherosclerosis.
C1 [Osada, Jesus] Univ Zaragoza, Sch Vet, Dept Biochem & Mol Biol, E-50013 Zaragoza, Spain.
   [Guillen, Natalia; Navarro, Maria A.; Barranquero, Cristina; Arnal, Carmen; Gascon, Sonia; Osada, Jesus] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr, Madrid, Spain.
   [Mourelle, Marisabel] Div Farmaceut Lacer SA, Dept I D, Dept Farmacol, Barcelona 08025, Spain.
   [Arnal, Carmen; Gascon, Sonia] Univ Zaragoza, Fac Vet, Dept Patol Anim, E-50013 Zaragoza, Spain.
   [Carnicer, Ricardo; Guillen, Natalia; Arbones-Mainar, Jose M.; Navarro, Maria A.; Guzman, Mario A.; Barranquero, Cristina; Acin, Sergio; Osada, Jesus] Univ Zaragoza, Dept Bioquim & Biol Mol & Celular, E-50013 Zaragoza, Spain.
C3 University of Zaragoza; CIBER - Centro de Investigacion Biomedica en
   Red; CIBEROBN; Instituto de Salud Carlos III; University of Zaragoza;
   University of Zaragoza
RP Osada, J (corresponding author), Univ Zaragoza, Sch Vet, Dept Biochem & Mol Biol, Miguel Servet 177, E-50013 Zaragoza, Spain.
EM Josada@unizar.es
RI Navarro, Ángeles/AAG-6089-2019; Guillén, Natalia/LCX-4359-2024;
   Arbones-Mainar, Jose/AGL-8624-2022; Barranquero, Cristina/LSM-4589-2024;
   Acin, Sergio/S-5185-2017
OI Carnicer Hijazo, Ricardo/0000-0002-7440-2964; Arbones-Mainar, Jose
   M/0000-0002-8982-3737; BARRANQUERO CORTES, CRISTINA/0000-0002-8442-8041;
   Guillen Monzon, Natalia/0000-0001-6627-298X; Acin,
   Sergio/0000-0001-7335-2865
FU LACER SA; FEDER-CICYT [SAF2007-60173]; Redes DGA [B-69]; FISS de
   investigacion cooperativa [C03-01, G03-140]; Fundacion Espa ola del
   Corazon; FEGA-FEOGA; PROMEP fellowships
FX This research was supported by grants from LACER SA, FEDER-CICYT
   (SAF2007-60173), Redes DGA (B-69), and FISS de investigacion cooperativa
   C03-01 and G03-140 and by Fundacion Espa ola del Corazon. R. C., S. A.,
   M. A. N., and M. A. G. G. were recipient of DGA, FEGA-FEOGA, and PROMEP
   fellowships. We thank Angel Beltran, Jes s Cazo, Jes s Navarro, Carmen
   Navarro, and Clara Tapia from Unidad Mixta de Investigacion for their
   invaluable help in maintaining animals.
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NR 44
TC 1
Z9 1
U1 0
U2 10
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0028-1298
EI 1432-1912
J9 N-S ARCH PHARMACOL
JI Naunyn-Schmiedebergs Arch. Pharmacol.
PD MAY
PY 2009
VL 379
IS 5
BP 489
EP 500
DI 10.1007/s00210-008-0377-5
PG 12
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 423KI
UT WOS:000264494800006
PM 19050853
DA 2025-06-11
ER

PT J
AU Ho, KJ
   Chen, TH
   Yang, CC
   Chuang, YC
   Chuang, HY
AF Ho, Kuo-Jung
   Chen, Tzu-Hua
   Yang, Chen-Cheng
   Chuang, Yao-Chung
   Chuang, Hung-Yi
TI Interaction of Smoking and Lead Exposure among Carriers of Genetic
   Variants Associated with a Higher Level of Oxidative Stress Indicators
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Article
DE lead; smoke; TBARS; OxLDL; GPx-1; CYBA; single nucleotide polymorphisms
ID GLUTATHIONE-PEROXIDASE DEFICIENCY; GPX1 PRO198LEU POLYMORPHISM;
   BREAST-CANCER RISK; BODY-MASS INDEX; SUPEROXIDE-PRODUCTION;
   LIPID-PEROXIDATION; NAD(P)H OXIDASE; NADPH-OXIDASE; ALCOHOL-CONSUMPTION;
   METABOLIC SYNDROME
AB Smoking and lead (Pb) exposure increased oxidative stress in human body, and people with some gene variants may be susceptible to Pb and smoking via oxidative stress. The aim of this study is to evaluate oxidative stress by measuring thiobarbituric acid reactive substances (TBARS) and the relationship of lipid peroxidation markers in Pb workers with different gene polymorphisms (rs4673 and rs1050450) in both smokers and nonsmokers. Blood samples were collected from 267 Pb workers who received their annual health examination in the Kaohsiung Medical University Hospital. Glutathione peroxidase 1 (GPx-1) rs1050450 and cytochrome B-245 Alpha Chain (CYBA) rs4673 single-nucleotide polymorphisms (SNP) were analyzed by specific primer-probes using Real-Time PCR methods. The interaction between blood Pb and smoking increased serum levels of TBARS and the ratio of oxidative low-density lipoprotein and low-density lipoprotein (oxLDL/LDL). Analysis of workers with rs1050450 SNPs showed higher blood Pb levels in the workers with CC genotype than those with CT genotype. Smokers had significantly higher blood Pb, alanine transaminase (ALT), TBARS, and OxLDL levels than nonsmokers. TBARS increased 0.009 nmol/mL when blood Pb increased one mu g/dL in smokers compared to nonsmokers. The ratio of OxLDL/LDL increased 0.223 when blood Pb increased one mu g/dL in smokers compared to nonsmokers. TBARS levels and the ratio of OxLDL/LDL were positively correlated and interacted between blood Pb and smoking after the adjustment of confounders, suggesting that smoking cessation is an important issue in the Pb-exposed working environment.
C1 [Ho, Kuo-Jung] Kaohsiung Med Univ, Coll Hlth Sci, Dept Publ Hlth, Kaohsiung 807, Taiwan.
   [Chen, Tzu-Hua] Kaohsiung Med Univ, Kaohsiung Municipal Ta Tung Hosp, Dept Family Med, Kaohsiung 807, Taiwan.
   [Yang, Chen-Cheng] Kaohsiung Med Univ, Kaohsiung Municipal Siaogang Hosp, Dept Occupat & Environm Med, Kaohsiung 807, Taiwan.
   [Chuang, Yao-Chung] Kaohsiung Chang Gung Mem Hosp, Inst Translat Res Biomed, Kaohsiung 833, Taiwan.
   [Chuang, Hung-Yi] Kaohsiung Med Univ Hosp, Dept Occupat & Environm Med, Kaohsiung 807, Taiwan.
   [Chuang, Hung-Yi] Kaohsiung Med Univ, Coll Med, Res Ctr Environm Med, Dept Publ Hlth & Environm Med, Kaohsiung 807, Taiwan.
C3 Kaohsiung Medical University; Kaohsiung Medical University; Kaohsiung
   Municipal Ta-Tung Hospital; Kaohsiung Medical University; Kaohsiung
   Municipal Siao-Gang Hospital; Chang Gung Memorial Hospital; Kaohsiung
   Medical University; Kaohsiung Medical University Hospital; Kaohsiung
   Medical University
RP Chuang, HY (corresponding author), Kaohsiung Med Univ Hosp, Dept Occupat & Environm Med, Kaohsiung 807, Taiwan.; Chuang, HY (corresponding author), Kaohsiung Med Univ, Coll Med, Res Ctr Environm Med, Dept Publ Hlth & Environm Med, Kaohsiung 807, Taiwan.
EM u103571002@kmu.edu.tw; 980264@kmuh.org.tw; 980309@kmuh.org.tw;
   ycchuang@adm.cgmh.org.tw; ericch@kmu.edu.tw
RI Yang, Chen-Cheng/EMM-0515-2022; Chuang, Hung-Yi/C-9143-2009
OI Chuang, Hung-Yi/0000-0002-8321-8720; Chuang,
   Yao-Chung/0000-0001-9131-7385
FU Ministry of Science and Technology [MOST108-2314-B-037-062]; Kaohsiung
   Medical University Hospital [KMUH109-9T05]; Kaohsiung Medical University
   [KMU-TC109A01-1]
FX This research was supported by Ministry of Science and Technology, grant
   number MOST108-2314-B-037-062, and Kaohsiung Medical University Hospital
   (KMUH109-9T05), and Kaohsiung Medical University (KMU-TC109A01-1).
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NR 73
TC 5
Z9 5
U1 0
U2 2
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD AUG
PY 2021
VL 18
IS 16
AR 8325
DI 10.3390/ijerph18168325
PG 12
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA UG4AD
UT WOS:000689196500001
PM 34444074
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Lavoie, S
   Steullet, P
   Kulak, A
   Preitner, F
   Do, KQ
   Magistretti, PJ
AF Lavoie, Suzie
   Steullet, Pascal
   Kulak, Anita
   Preitner, Frederic
   Do, Kim Q.
   Magistretti, Pierre J.
TI Glutamate Cysteine Ligase-Modulatory Subunit Knockout Mouse Shows Normal
   Insulin Sensitivity but Reduced Liver Glycogen Storage
SO FRONTIERS IN PHYSIOLOGY
LA English
DT Article
DE glutathione; GCLM knockout; glycogen; insulin; glycemia;
   resident-intruder stress; cortisol
ID REACTIVE OXYGEN; OXIDATIVE STRESS; GLUCOSE-HOMEOSTASIS; GLUTATHIONE;
   METABOLISM; NEURONS; DISEASE; RISK; GSH; SCHIZOPHRENIA
AB Glutathione (GSH) deficits have been observed in several mental or degenerative illness, and so has the metabolic syndrome. The impact of a decreased glucose metabolism on the GSH system is well-known, but the effect of decreased GSH levels on the energy metabolism is unclear. The aim of the present study was to investigate the sensitivity to insulin in the mouse knockout (KO) for the modulatory subunit of the glutamate cysteine ligase (GCLM), the rate -limiting enzyme of GSH synthesis. Compared to wildtype (WT) mice, GCLM KO mice presented with reduced basal plasma glucose and insulin levels. During an insulin tolerance test, GCLM-KO mice showed a normal fall in glycemia, indicating normal insulin secretion. However, during the recovery phase, plasma glucose levels remained lower for longer in KO mice despite normal plasma glucagon levels. This is consistent with a normal counterregulatory hormonal response but impaired mobilization of glucose from endogenous stores. Following a resident -intruder stress, during which stress hormones mobilize glucose from hepatic glycogen stores, KO mice showed a lower hyperglycemic level despite higher plasma cortisol levels when compared to WT mice. The lower hepatic glycogen levels observed in GCLM-KO mice could explain the impaired glycogen mobilization following induced hypoglycemia. Altogether, our results indicate that reduced liver glycogen availability, as observed in GCLM-KO mice, could be at the origin of their lower basal and challenged glycemia. Further studies will be necessary to understand how a GSH deficit, typically observed in GCLM-KO mice, leads to a deficit in liver glycogen storage.
C1 [Lavoie, Suzie; Steullet, Pascal; Kulak, Anita; Do, Kim Q.; Magistretti, Pierre J.] Univ Lausanne Hosp, Ctr Psychiat Neurosci, Dept Psychiat, Lausanne, Switzerland.
   [Lavoie, Suzie; Steullet, Pascal; Kulak, Anita; Do, Kim Q.; Magistretti, Pierre J.] Univ Lausanne, Lausanne, Switzerland.
   [Lavoie, Suzie] Univ Melbourne, Ctr Youth Mental Hlth, Oryaen, Parkville, Vic 3052, Australia.
   [Preitner, Frederic] Univ Lausanne, Mouse Metab Evaluat Facil, Ctr Integrat Genom, Lausanne, Switzerland.
   [Magistretti, Pierre J.] Ecole Polytech Fed Lausanne, Lab Neuroenerget & Cellular Dynam, Brain Mind Inst, Lausanne, Switzerland.
   [Magistretti, Pierre J.] KAUST, BESE Div, Thuwal, Saudi Arabia.
C3 University of Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV);
   University of Lausanne; University of Melbourne; Orygen, The National
   Centre of Excellence in Youth Mental Health; University of Lausanne;
   Swiss Federal Institutes of Technology Domain; Ecole Polytechnique
   Federale de Lausanne; King Abdullah University of Science & Technology
RP Lavoie, S (corresponding author), Univ Lausanne Hosp, Ctr Psychiat Neurosci, Dept Psychiat, Lausanne, Switzerland.; Lavoie, S (corresponding author), Univ Lausanne, Lausanne, Switzerland.; Lavoie, S (corresponding author), Univ Melbourne, Ctr Youth Mental Hlth, Oryaen, Parkville, Vic 3052, Australia.
EM suzie.lavoie@orygen.org.au
RI Lavoie, Suzie/H-1462-2011; Magistretti, Pierre/ABV-1846-2022; Do, Kim
   Q./G-6694-2016
OI Do, Kim Q./0000-0003-1968-1646; Magistretti, Pierre
   Julius/0000-0002-6678-320X; Steullet, Pascal/0000-0002-7025-2903
FU Swiss National Foundation [310000-116689]; MTR schizophrenia of the
   Department of Psychiatry of the ausanne University Hospital; EPFL
FX This work was financially supported by the Swiss National Foundation No
   310000-116689 and the MTR schizophrenia of the Department of Psychiatry
   of the ausanne University Hospital and the EPFL.
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NR 47
TC 4
Z9 4
U1 0
U2 4
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-042X
J9 FRONT PHYSIOL
JI Front. Physiol.
PD APR 21
PY 2016
VL 7
AR 142
DI 10.3389/fphys.2016.00142
PG 8
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA DJ8GU
UT WOS:000374451400001
PM 27148080
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Di Fulvio, P
   Pandolfi, A
   Formoso, G
   Di Silvestre, S
   Di Tomo, P
   Giardinelli, A
   De Marco, A
   Di Pietro, N
   Taraborrelli, M
   Sancilio, S
   Di Pietro, R
   Piantelli, M
   Consoli, A
AF Di Fulvio, P.
   Pandolfi, A.
   Formoso, G.
   Di Silvestre, S.
   Di Tomo, P.
   Giardinelli, A.
   De Marco, A.
   Di Pietro, N.
   Taraborrelli, M.
   Sancilio, S.
   Di Pietro, R.
   Piantelli, M.
   Consoli, A.
TI Features of endothelial dysfunction in umbilical cord vessels of women
   with gestational diabetes
SO NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
LA English
DT Article
DE HUVEC; GDM; NO bioavailability; Nitrotyrosine; Oxidative stress
ID OXIDATIVE STRESS; EXPRESSION; INFLAMMATION; ATHEROSCLEROSIS; INSIGHTS;
   CELLS; ENOS
AB Background and aims: Gestational diabetes (GDM) is associated with increased oxidative stress and overexpression of inflammatory cytokines, both of which might lead to endothelial dysfunction and vascular disease. As such, GDM could be viewed as a sort of 'short lived' metabolic syndrome. As umbilical cord vessels represent a suitable model for the study of vascular alterations brought about by GDM, the aim of the present work was to characterize the phenotype of human umbilical vein endothelial cells (HUVECs) chronically exposed to hyperglycaemia and to a pro-inflammatory environment during pregnancy so as to identify molecular modifications of cellular homoeostasis eventually impacting on endothelial dysfunction.
   Methods and result: Tissue specimens and HUVECs were obtained from umbilical cords of GDM and control women. As compared to controls, GD-HUVEC exhibited enhanced monocyte adhesion and vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1) expression and exposure on plasma membrane after tumour necrosis factor-alpha (TNF-alpha) stimulation (Western blot, flow cytometer). As compared to control cells, GD-HUVEC in basal conditions exhibited enhanced monocyte adhesion, nitric oxide synthase (NOS) expression and activity (eNOS Real-Time polymerase chain reaction, Western Blot for eNOS total protein and monomers/dimers ratio, conversion of [3H]-L-arginine in [3H]-L-citrulline), increased O-2(-) generation together with increased NT levels (immunofluorescence) and reduced NO bioavailability (guanosine 30,50-monophosphate (cGMP) production, EIA). Furthermore, immunohistochemistry revealed increased eNOS and NT immunoreactivity in GD umbilical cords.
   Conclusion: Endothelial cells exposed in vivo even transiently to hyperglycaemia, oxidative stress and inflammation exhibit durable pro-atherogenic modifications. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Di Fulvio, P.; Formoso, G.; De Marco, A.; Taraborrelli, M.; Di Pietro, R.; Consoli, A.] Univ G DAnnunzio, Dept Med & Aging Sci, I-66100 Chieti, Italy.
   [Di Fulvio, P.; Formoso, G.; Taraborrelli, M.; Consoli, A.] Pescara Town Hosp, Diabet Serv, Pescara, Italy.
   [Pandolfi, A.; Di Silvestre, S.; Di Tomo, P.; Giardinelli, A.; Di Pietro, N.; Piantelli, M.] Univ G DAnnunzio, Dept Clin & Expt Sci, I-66100 Chieti, Italy.
   [Sancilio, S.] Univ G DAnnunzio, Dept Pharm, I-66100 Chieti, Italy.
   [Piantelli, M.] Univ G dAnnunzio, Aging Res Ctr, Chieti, Italy.
C3 G d'Annunzio University of Chieti-Pescara; G d'Annunzio University of
   Chieti-Pescara; G d'Annunzio University of Chieti-Pescara; G d'Annunzio
   University of Chieti-Pescara
RP Consoli, A (corresponding author), Univ G DAnnunzio, Dept Med & Aging Sci, Edificio CeSi,Room 271,Via Colle dellAra 1, I-66100 Chieti, Italy.
EM consoli@unich.it
RI Consoli, Agostino/J-8027-2018; FORMOSO, GLORIA/J-7064-2018; PANDOLFI,
   Assunta/K-4595-2016; Di Pietro, Natalia/K-1604-2016
OI PANDOLFI, Assunta/0000-0003-4135-7631; Di Pietro,
   Natalia/0000-0001-9720-2116; consoli, agostino/0000-0002-1885-451X
FU European Foundation for the Study of Diabetes; MIPAAF (CARONUT); SID
   Research Fellowship (FoRiSID)
FX This work was supported by an European Foundation for the Study of
   Diabetes 2010 research grant to AC and MIPAAF (CARONUT) 2008 research
   grant to AP. MT's salary was partially supported by SID Research
   Fellowship 2008 (FoRiSID).
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NR 30
TC 61
Z9 63
U1 0
U2 11
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0939-4753
EI 1590-3729
J9 NUTR METAB CARDIOVAS
JI Nutr. Metab. Carbiovasc. Dis.
PD DEC
PY 2014
VL 24
IS 12
BP 1337
EP 1345
DI 10.1016/j.numecd.2014.06.005
PG 9
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism; Nutrition
   & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism;
   Nutrition & Dietetics
GA AZ2CU
UT WOS:000348043200011
PM 25438716
DA 2025-06-11
ER

PT J
AU Kim, JE
   Lee, MH
   Nam, DH
   Song, HK
   Kang, YS
   Lee, JE
   Kim, HW
   Cha, JJ
   Hyun, YY
   Han, SY
   Han, KH
   Han, JY
   Cha, DR
AF Kim, Jung Eun
   Lee, Mi Hwa
   Nam, Deok Hwa
   Song, Hye Kyoung
   Kang, Young Sun
   Lee, Ji Eun
   Kim, Hyun Wook
   Cha, Jin Joo
   Hyun, Young Youl
   Han, Sang Youb
   Han, Kum Hyun
   Han, Jee Young
   Cha, Dae Ryong
TI Celastrol, an NF-κB Inhibitor, Improves Insulin Resistance and
   Attenuates Renal Injury in db/db Mice
SO PLOS ONE
LA English
DT Article
ID DIABETIC-NEPHROPATHY; INDUCED INFLAMMATION; TRANSCRIPTION FACTOR;
   METABOLIC SYNDROME; OXIDATIVE STRESS; BINDING-ACTIVITY; MESANGIAL CELLS;
   ADIPOSE-TISSUE; ACTIVATION; PATHWAY
AB The NF-kappa B pathway plays an important role in chronic inflammatory and autoimmune diseases. Recently, NF-kappa B has also been suggested as an important mechanism linking obesity, inflammation, and metabolic disorders. However, there is no current evidence regarding the mechanism of action of NF-kappa B inhibition in insulin resistance and diabetic nephropathy in type 2 diabetic animal models. We investigated the effects of the NF-kappa B inhibitor celastrol in db/db mice. The treatment with celastrol for 2 months significantly lowered fasting plasma glucose (FPG), HbA1C and homeostasis model assessment index (HOMA-IR) levels. Celastrol also exhibited significant decreases in body weight, kidney/body weight and adiposity. Celastrol reduced insulin resistance and lipid abnormalities and led to higher plasma adiponectin levels. Celastrol treatment also significantly mitigated lipid accumulation and oxidative stress in organs including the kidney, liver and adipose tissue. The treated group also exhibited significantly lower creatinine levels and urinary albumin excretion was markedly reduced. Celastrol treatment significantly lowered mesangial expansion and suppressed type IV collagen, PAI-1 and TGF beta 1 expressions in renal tissues. Celastrol also improved abnormal lipid metabolism, oxidative stress and proinflammatory cytokine activity in the kidney. In cultured podocytes, celastrol treatment abolished saturated fatty acid-induced proinflammatory cytokine synthesis. Taken together, celastrol treatment not only improved insulin resistance, glycemic control and oxidative stress, but also improved renal functional and structural changes through both metabolic and anti-inflammatory effects in the kidney. These results suggest that targeted therapy for NF-kappa B may be a useful new therapeutic approach for the management of type II diabetes and diabetic nephropathy.
C1 [Kim, Jung Eun; Lee, Mi Hwa; Nam, Deok Hwa; Song, Hye Kyoung; Kang, Young Sun; Cha, Jin Joo; Cha, Dae Ryong] Korea Univ, Dept Internal Med, Div Nephrol, Ansan, Kyungki Do, South Korea.
   [Lee, Ji Eun; Kim, Hyun Wook] Wonkwang Univ, Dept Internal Med, Div Nephrol, Gunpo City, Kyungki Do, South Korea.
   [Hyun, Young Youl] Sungkyunkwan Univ, Dept Internal Med, Div Nephrol, Seoul, South Korea.
   [Han, Sang Youb; Han, Kum Hyun] Inje Univ, Dept Internal Med, Div Nephrol, Goyang City, Kyungki Do, South Korea.
   [Han, Jee Young] Inha Univ, Dept Pathol, Inchon, Kyungki Do, South Korea.
C3 Korea University; Korea University Medicine (KU Medicine); Wonkwang
   University; Sungkyunkwan University (SKKU); Inje University; Inha
   University
RP Cha, DR (corresponding author), Korea Univ, Dept Internal Med, Div Nephrol, Ansan, Kyungki Do, South Korea.
EM cdragn@unitel.co.kr
RI LEE, JIEUN/HTN-1777-2023; Lee, Seung Soo/GRR-3802-2022
FU Korea Research Foundation; Korean Government (MOEHRD)
   [KRF-2010-T1102051]; Korea University [R1003201]
FX This work was supported by the Korea Research Foundation Grant funded by
   the Korean Government (MOEHRD) as a Brain Korea 21 project (grant number
   KRF-2010-T1102051) and a special grant from Korea University (grant
   number R1003201). The funders had no role in study design, data
   collection and analysis, decision to publish, or preparation of the
   manuscript.
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NR 43
TC 117
Z9 134
U1 1
U2 49
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD APR 26
PY 2013
VL 8
IS 4
AR e62068
DI 10.1371/journal.pone.0062068
PG 11
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 136EF
UT WOS:000318343700030
PM 23637966
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Noshadi, N
   Sabet, SS
   Sanaie, S
   Mahmoodpoor, A
   Tutunchi, H
   Naghshi, S
   Arefhosseini, SR
   Ebrahimi-Mameghani, M
AF Noshadi, Nooshin
   Sabet, Seyede Sana
   Sanaie, Sarvin
   Mahmoodpoor, Ata
   Tutunchi, Helda
   Naghshi, Sina
   Arefhosseini, Seyed Rafie
   Ebrahimi-Mameghani, Mehrangiz
TI The effects of seven-strain probiotic supplementation on cell adhesion
   molecules, oxidative stress and antioxidant parameters in patients with
   traumatic brain injury: a randomised controlled clinical trial
SO BRITISH JOURNAL OF NUTRITION
LA English
DT Article; Early Access
DE Probiotic; Oxidative stress; Pro-oxidant-antioxidant balance; Cell
   adhesion molecules; Traumatic brain injury
ID CRITICALLY-ILL PATIENTS; DOUBLE-BLIND; METABOLIC SYNDROME; INFLAMMATION;
   HEMODIALYSIS; WOMEN; MODEL
AB The therapeutic effects of probiotics in patients with traumatic brain injury (TBI) remain unclear. This study aimed to investigate the effects of probiotic supplementation on cell adhesion molecules (CAMs), oxidative stress and antioxidant parameters in TBI patients. This randomised, double-blind, placebo-controlled trial included forty-six TBI patients who were randomly assigned to receive either a probiotic supplement (n 23) or a placebo (n 23) for 14 d. The probiotic capsule contained four strains of Lactobacillus (L. casei, L. bulgaricus, L. rhamnosus, L. acidophilus), two strains of Bifidobacterium (B. longum, B. breve) and Streptococcus thermophilus. Serum levels of intercellular adhesion molecule (ICAM)-1, vascular cell adhesion molecule (VCAM)-1, pro-oxidant-antioxidant balance (PAB), malondialdehyde (MDA), nitric oxide (NO), total antioxidant capacity (TAC) and arylesterase (ARE) activity were measured at the beginning and end of the trial. Dietary intakes of patients were also recorded at the beginning and end of the trial. At the end of the study, there were no significant changes in ICAM-1, VCAM-1, PAB, MDA, NO, TAC and ARE levels. However, patients who received probiotic supplements had significantly increased dietary intakes of energy, macronutrients, vitamin E, Zn, Cu and Se compared with the placebo group. This study provides evidence that probiotic supplementation for 14 d in TBI patients has beneficial effects on dietary intake. However, it did not affect serum levels of CAMs, oxidative stress or antioxidant parameters. These findings should be considered preliminary, and further research is needed to evaluate long-term and clinical outcomes.
C1 [Noshadi, Nooshin; Sabet, Seyede Sana; Naghshi, Sina] Tabriz Univ Med Sci, Student Res Comm, Fac Nutr & Food Sci, Dept Clin Nutr, Tabriz, Iran.
   [Sanaie, Sarvin; Mahmoodpoor, Ata] Tabriz Univ Med Sci, Aging Res Inst, Res Ctr Integrat Med Aging, Tabriz, Iran.
   [Tutunchi, Helda] Tabriz Univ Med Sci, Endocrine Res Ctr, Tabriz, Iran.
   [Arefhosseini, Seyed Rafie] Tabriz Univ Med Sci, Fac Nutr & Food Sci, Dept Biochem & Diet Therapy, Tabriz, Iran.
   [Ebrahimi-Mameghani, Mehrangiz] Tabriz Univ Med Sci, Fac Nutr & Food Sci, Nutr Res Ctr, Dept Biochem & Diet Therapy, Tabriz, Iran.
C3 Tabriz University of Medical Science; Tabriz University of Medical
   Science; Tabriz University of Medical Science; Tabriz University of
   Medical Science; Tabriz University of Medical Science
RP Ebrahimi-Mameghani, M (corresponding author), Tabriz Univ Med Sci, Fac Nutr & Food Sci, Nutr Res Ctr, Dept Biochem & Diet Therapy, Tabriz, Iran.
EM ebrahimimamagani@tbzmed.ac.ir
RI Ebrahimi-Mameghani, Mehrangiz/G-6461-2017
OI Ebrahimi-Mameghani, Mehrangiz/0000-0002-0311-1289
FU Tabriz University of Medical Sciences [65 716]
FX This research was funded by Tabriz University of Medical Sciences
   [grantnumber: 65 716].
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NR 57
TC 1
Z9 1
U1 1
U2 1
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1145
EI 1475-2662
J9 BRIT J NUTR
JI Br. J. Nutr.
PD 2025 JAN 23
PY 2025
DI 10.1017/S0007114524003234
EA JAN 2025
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 3HE0U
UT WOS:001500240500001
PM 39844647
DA 2025-06-11
ER

PT J
AU Oh, SJ
   Hwang, Y
   Hur, KY
   Lee, MS
AF Oh, Soo-Jin
   Hwang, Yeseong
   Hur, Kyu Yeon
   Lee, Myung-Shik
TI Lysosomal Ca<SUP>2+</SUP> as a mediator of palmitate-induced
   lipotoxicity
SO CELL DEATH DISCOVERY
LA English
DT Article
ID MITOCHONDRIAL PERMEABILITY TRANSITION; CELL-DEATH; INSULIN-RESISTANCE;
   FATTY-ACIDS; BETA-CELLS; INHIBITION; CALCIUM; APOPTOSIS; RELEASE; STRESS
AB While the mechanism of lipotoxicity by palmitic acid (PA), an effector of metabolic stress in vitro and in vivo, has been extensively investigated, molecular details of lipotoxicity are still not fully characterized. Since recent studies reported that PA can exert lysosomal stress in addition to well-known ER and mitochondrial stress, we studied the role of lysosomal events in lipotoxicity by PA, focusing on lysosomal Ca2+. We found that PA induced accumulation of mitochondrial ROS and that mitochondrial ROS induced release of lysosomal Ca2+ due to lysosomal Ca2+ exit channel activation. Lysosomal Ca2+ release led to increased cytosolic Ca2+ which induced mitochondrial permeability transition (mPT). Chelation of cytoplasmic Ca2+ or blockade of mPT with olesoxime or decylubiquinone (DUB) suppressed lipotoxicity. Lysosomal Ca2+ release led to reduced lysosomal Ca2+ content which was replenished by ER Ca2+, the largest intracellular Ca2+ reservoir (ER -> lysosome Ca2+ refilling), which in turn activated store-operated Ca2+ entry (SOCE). Inhibition of ER -> lysosome Ca2+ refilling by blockade of ER Ca2+ exit channel using dantrolene or inhibition of SOCE using BTP2 inhibited lipotoxicity in vitro. Dantrolene or DUB also inhibited lipotoxic death of hepatocytes in vivo induced by administration of ethyl palmitate together with LPS. These results suggest a novel pathway of lipotoxicity characterized by mPT due to lysosomal Ca2+ release which was supplemented by ER -> lysosome Ca2+ refilling and subsequent SOCE, and also suggest the potential role of modulation of ER -> lysosome Ca2+ refilling by dantrolene or other blockers of ER Ca2+ exit channels in disease conditions characterized by lipotoxicity such as metabolic syndrome, diabetes, cardiomyopathy or nonalcoholic steatohepatitis.
C1 [Oh, Soo-Jin] Sungkyunkwan Univ, Dept Hlth Sci & Technol, SAIHST, Seoul 06355, South Korea.
   [Oh, Soo-Jin; Lee, Myung-Shik] Soonchunhyang Univ, Soonchunhyang Inst Medi bio Sci, Soonchunhyang Med Ctr, Dept Integrated Biomed Sci,Coll Med, Cheonan, South Korea.
   [Oh, Soo-Jin; Lee, Myung-Shik] Soonchunhyang Univ, Soonchunhyang Med Ctr, Dept Internal Med, Coll Med, Cheonan, South Korea.
   [Hwang, Yeseong; Lee, Myung-Shik] Yonsei Univ, Severance Biomed Sci Inst, Grad Sch Med Sci, BK21 Project ,Coll Med, Seoul 03722, South Korea.
   [Hur, Kyu Yeon] Sungkyunkwan Univ, Samsung Med Ctr, Dept Med, Sch Med, Seoul, South Korea.
C3 Sungkyunkwan University (SKKU); Soonchunhyang University; Soonchunhyang
   University; Yonsei University; Yonsei University Health System;
   Sungkyunkwan University (SKKU); Samsung Medical Center
RP Lee, MS (corresponding author), Soonchunhyang Univ, Soonchunhyang Inst Medi bio Sci, Soonchunhyang Med Ctr, Dept Integrated Biomed Sci,Coll Med, Cheonan, South Korea.; Lee, MS (corresponding author), Soonchunhyang Univ, Soonchunhyang Med Ctr, Dept Internal Med, Coll Med, Cheonan, South Korea.; Lee, MS (corresponding author), Yonsei Univ, Severance Biomed Sci Inst, Grad Sch Med Sci, BK21 Project ,Coll Med, Seoul 03722, South Korea.
EM mslee0923@sch.ac.kr
RI Lee, Myung/C-9606-2011
OI Oh, Soo-Jin/0000-0001-9267-2039; Lee, Myung-Shik/0000-0003-3292-1720;
   Hwang, Yeseong/0000-0002-1739-4443
FU National Research Foundation of Korea (NRF) - Korea government (MSIT)
   [NRF-2019R1A2C3002924]; Bio&Medical Technology Development Program
   [2017M3A9G7073521]; Ministry of Science & ICT, Ministry of Trade,
   Industry Energy; Ministry of Health Welfare [HN22C0278]; Faculty
   Research Assistance Program of Soonchunhyang University [20220346]
FX This study was supported by a National Research Foundation of Korea
   (NRF) grant funded by the Korea government (MSIT) (NRF-2019R1A2C3002924)
   and by the Bio & Medical Technology Development Program
   (2017M3A9G7073521). M-S Lee is the recipient of Korea Drug Development
   Fund from the Ministry of Science & ICT, Ministry of Trade, Industry &
   Energy and Ministry of Health & Welfare (HN22C0278), and a grant from
   the Faculty Research Assistance Program of Soonchunhyang University
   (20220346).
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NR 54
TC 5
Z9 5
U1 1
U2 9
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
EI 2058-7716
J9 CELL DEATH DISCOV
JI Cell Death Discov.
PD MAR 21
PY 2023
VL 9
IS 1
AR 100
DI 10.1038/s41420-023-01379-0
PG 12
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA A3VG8
UT WOS:000954435500001
PM 36944629
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Wang, WN
   Zhou, W
   Wang, BL
   Zhu, HY
   Ye, L
   Feng, MQ
AF Wang, Weina
   Zhou, Wei
   Wang, Baolong
   Zhu, Haiyan
   Ye, Li
   Feng, Meiqing
TI Antioxidant effect of apolipoprotein A-I on high-fat diet-induced
   non-alcoholic fatty liver disease in rabbits
SO ACTA BIOCHIMICA ET BIOPHYSICA SINICA
LA English
DT Article
DE apolipoprotein A-I; lipid peroxidation; oxidative stress; non-alcoholic
   fatty liver
ID HIGH-DENSITY-LIPOPROTEIN; OXIDATIVE STRESS; METABOLIC SYNDROME; INHIBITS
   3; STEATOHEPATITIS; PROGRESSION; MECHANISMS; STEPS
AB Non-alcoholic fatty liver disease (NAFLD) is an increasingly recognized condition that encompasses a spectrum of liver abnormalities. It has been suggested that oxidative stress and lipid peroxidation are key pathophysiological mechanisms in NAFLD. Although an antioxidant effect of apolipoprotein A-I (apoA-I) has been reported, its influence on NAFLD has not been reported. The aim of this study was to determine whether apoA-I could improve the biochemical and histological abnormalities associated with high-fat diet-induced NAFLD through its antioxidant actions in rabbits. Liver damage was evaluated by hepatic coefficient, hepatic lipid assay, liver apparent abnormalities as well as hematoxylineosin staining of liver sections. Lipid peroxidation was assessed by measuring malondialdehyde (MDA) level in liver. Oxidative stress was assessed by measuring superoxide dismutase (SOD), glutathione peroxidase (GPx), and inducible nitric oxide synthase (iNOS) activities in serum and liver. Also, the mRNA expressions levels of SOD, GPx, and catalase (CAT) were determined by real-time quantitative polymerase chain reaction method. The results showed that apoA-I (20 or 40 mg/kg/w) was effective in reducing hepatic steatosis, inflammation, hepatic coefficient, and liver total cholesterol, triglyceride, low-density lipoprotein-cholesterol, and MDA levels in high-fat diet rabbits. In addition, apoA-I increased SOD and GPx activities while reducing iNOS activity in serum and liver. Moreover, apoA-I significantly increased the mRNA expression levels of SOD, GPx, and CAT in liver. This study showed that apoA-I exerted protective effects against fatty liver disease in rabbits induced by a high-fat diet, possibly through its antioxidant actions.
C1 [Wang, Weina; Zhou, Wei; Wang, Baolong; Zhu, Haiyan; Ye, Li; Feng, Meiqing] Fudan Univ, Dept Pharmacol, Shanghai 201203, Peoples R China.
C3 Fudan University
RP Feng, MQ (corresponding author), Fudan Univ, Dept Pharmacol, Shanghai 201203, Peoples R China.
EM fmeiqing@126.com
RI zhu, xueqiong/U-1320-2019
FU National Natural Science Foundation of China [30973684]; Shanghai
   Science and Technology Commission [0952nm03500]
FX The work was supported by the grants from the National Natural Science
   Foundation of China (30973684) and Shanghai Science and Technology
   Commission (0952nm03500).
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NR 35
TC 17
Z9 18
U1 0
U2 28
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1672-9145
EI 1745-7270
J9 ACTA BIOCH BIOPH SIN
JI Acta Biochim. Biophys. Sin.
PD FEB
PY 2013
VL 45
IS 2
BP 95
EP 103
DI 10.1093/abbs/gms100
PG 9
WC Biochemistry & Molecular Biology; Biophysics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics
GA 077VX
UT WOS:000314058500004
PM 23174676
DA 2025-06-11
ER

PT J
AU Tamaki, S
   Yamauchi, M
   Fukuoka, A
   Makinodan, K
   Koyama, N
   Tomoda, K
   Yoshikawa, M
   Kimura, H
AF Tamaki, Shinji
   Yamauchi, Motoo
   Fukuoka, Atsuhiko
   Makinodan, Kiyoshi
   Koyama, Noriko
   Tomoda, Koichi
   Yoshikawa, Masanori
   Kimura, Hiroshi
TI Nocturnal hypoxic stress activates invasive ability of monocytes in
   patients with obstructive sleep apnoea syndrome
SO RESPIROLOGY
LA English
DT Article
DE atherosclerosis; hypoxia; monocyte; sleep apnoea
ID FACTOR-KAPPA-B; CARDIOVASCULAR-DISEASE; ADHESION MOLECULES; METABOLIC
   SYNDROME; LUNG INJURY; ATHEROSCLEROSIS; MECHANISMS; MIGRATION;
   CHEMOKINES; CYTOKINES
AB Background and objective:
   Obstructive sleep apnoea syndrome (OSAS) is known to be a risk factor for cardiovascular events. However, the precise mechanism has not been fully elucidated. OSAS-induced hypoxic stress may promote the production of inflammatory cytokines and chemokines by monocytes, which has a crucial role in the development of atherosclerosis. In addition, adhesion to the vascular endothelium and transendothelial migration of monocytes are considered to induce atherosclerosis. The aim of this study was to investigate the effects of hypoxic stress on the invasive ability of monocytes in OSAS.
   Methods:
   Twenty-one male patients with OSAS and 17 healthy male control subjects, who were matched for age and BMI, were enrolled. Venous blood samples were collected before and after sleep, and also after CPAP titration, for the purpose of monocyte isolation. The invasive ability of monocytes was evaluated by counting the number of invading cells using a BD BioCoat Matrigel Invasion Chamber.
   Results:
   The number of cells, which represents the invasive ability of monocytes, was significantly higher in patients with OSAS compared with control subjects, in the early morning (P < 0.001). In patients with OSAS, invasive ability in the early morning after sleep was significantly elevated as compared with that before sleep (P < 0.001), and was positively correlated with the oxygen desaturation index (P < 0.05). CPAP titration led to a decrease in the invasive ability (P < 0.001).
   Conclusions:
   These results indicate that OSAS-induced hypoxic stress activates the invasive ability of monocytes, and that the occurrence of this phenomenon during sleep may contribute to the development of atherosclerosis in OSAS.
C1 [Tamaki, Shinji; Yamauchi, Motoo; Fukuoka, Atsuhiko; Makinodan, Kiyoshi; Koyama, Noriko; Tomoda, Koichi; Yoshikawa, Masanori; Kimura, Hiroshi] Nara Med Univ, Dept Internal Med 2, Nara 6348522, Japan.
   Nara Med Univ, Second Dept Internal Med, Nara, Japan.
C3 Nara Medical University; Nara Medical University
RP Kimura, H (corresponding author), Nara Med Univ, Dept Internal Med 2, 840 Shijo Cho, Nara 6348522, Japan.
EM kimura@nmu-gw.naramed-u.ac.jp
RI Kimura, Hiroshi/AGU-7339-2022; Yamauchi, Motoo/AAV-8338-2020
OI Yamauchi, Motoo/0000-0003-1754-703X
FU Ministry of Health, Labour and Welfare, Japan; Ministry of Education,
   Science, Sports and Culture, Japan [19390226]; Grants-in-Aid for
   Scientific Research [19390226] Funding Source: KAKEN
FX This study was partly supported by a grant to the Respiratory Failure
   Research Group from the Ministry of Health, Labour and Welfare, Japan,
   and by a Grant-in-Aid for Scientific Research (B)(19390226) from the
   Ministry of Education, Science, Sports and Culture, Japan.
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NR 36
TC 21
Z9 22
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1323-7799
EI 1440-1843
J9 RESPIROLOGY
JI Respirology
PD JUL
PY 2009
VL 14
IS 5
BP 689
EP 694
DI 10.1111/j.1440-1843.2009.01540.x
PG 6
WC Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Respiratory System
GA 471MH
UT WOS:000268061300010
PM 19476600
DA 2025-06-11
ER

PT J
AU Papageorgiou, I
   Viglino, C
   Brulhart-Meynet, MC
   James, RW
   Lerch, R
   Montessuit, C
AF Papageorgiou, I.
   Viglino, C.
   Brulhart-Meynet, M. -C.
   James, R. W.
   Lerch, R.
   Montessuit, C.
TI Impaired stimulation of glucose transport in cardiac myocytes exposed to
   very low-density lipoproteins
SO NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
LA English
DT Article
DE VLDL; Fatty acids; Insulin; Metabolic stress; Glucose transport; Cardiac
   myocytes
ID RICH LIPOPROTEINS; FATTY-ACIDS; RAT-HEART; CARDIOMYOCYTES; GLUT4;
   METABOLISM; RECEPTOR; LIPASE; TRANSLOCATION; DYSFUNCTION
AB We recently observed that free fatty acids impair the stimulation of glucose transport into cardiomyocytes in response to either insulin or metabolic stress. In vivo, fatty acids for the myocardium are mostly obtained from triglyceride-rich lipoproteins (chylomicrons and Very Low-Density Lipoproteins). We therefore determined whether exposure of cardiac myocytes to VLDL resulted in impaired basal and stimulated glucose transport. Primary adult rat cardiac myocytes were chronically exposed to VLDL before glucose uptake was measured in response to insulin or metabolic stress, provoked by the mitochondrial ATP synthase inhibitor oligomycin. Exposure of cardiac myocytes to VLDL reduced both insulin-and oligomycin-stimulated glucose uptake. The reduction of glucose uptake was associated with a moderately reduced tyrosine phosphorylation of the insulin receptor. No reduction of the phosphorylation of the downstream effectors of insulin signaling Akt and AS160 was however observed. Similarly only a modest reduction of the activating phosphorylation of the AMP-activated kinase (AMPK) was observed in response to oligomycin. Similar to our previous observations with free fatty acids, inhibition of fatty acid oxidation restored oligomycin-stimulated glucose uptake. In conclusions, VLDL-derived fatty acids impair stimulated glucose transport in cardiac myocytes by a mechanism that seems to be mediated by a fatty acid oxidation intermediate. Thus, in the clinical context of the metabolic syndrome high VLDL may contribute to enhancement of ischemic injury by reduction of metabolic stress-stimulated glucose uptake. (C) 2016 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.
C1 [Papageorgiou, I.; Lerch, R.; Montessuit, C.] Univ Hosp Geneva, Dept Med Specialties, Div Cardiol, Geneva, Switzerland.
   [Papageorgiou, I.; Viglino, C.; Montessuit, C.] Univ Geneva, Sch Med, Fdn Med Res, 64 Ave Roseraie, CH-1211 Geneva 4, Switzerland.
   [Brulhart-Meynet, M. -C.; James, R. W.] Univ Hosp Geneva, Dept Med Specialties, Div Endocrinol & Diabetol, Geneva, Switzerland.
C3 University of Geneva; University of Geneva; University of Geneva
RP Montessuit, C (corresponding author), Univ Geneva, Sch Med, Fdn Med Res, 64 Ave Roseraie, CH-1211 Geneva 4, Switzerland.
EM christophe.montessuit@unige.ch
RI Montessuit, Christophe/B-5650-2011
OI Montessuit, Christophe/0000-0002-2580-7711
FU HSwiss National Science Foundation [310030_138250, 310030_146537];
   "Fondation Centre de Recherche Medicale Carlos et Elsie de Reuter"
   [543]; Fondation Gustave et Simone Prevot; Swiss National Science
   Foundation (SNF) [310030_146537] Funding Source: Swiss National Science
   Foundation (SNF)
FX This work was supported by grants from the HSwiss National Science
   Foundation (#310030_138250 and #310030_146537 to CM), from the
   "Fondation Centre de Recherche Medicale Carlos et Elsie de Reuter" (#543
   to CM) and the Fondation Gustave et Simone Prevot.
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NR 29
TC 6
Z9 6
U1 0
U2 1
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0939-4753
EI 1590-3729
J9 NUTR METAB CARDIOVAS
JI Nutr. Metab. Carbiovasc. Dis.
PD JUL
PY 2016
VL 26
IS 7
BP 614
EP 622
DI 10.1016/j.numecd.2016.01.010
PG 9
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism; Nutrition
   & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism;
   Nutrition & Dietetics
GA DN8XG
UT WOS:000377362600008
PM 27052924
DA 2025-06-11
ER

PT J
AU Wang, L
   Yamasaki, M
   Katsube, T
   Sun, XF
   Yamasaki, Y
   Shiwaku, K
AF Wang, Li
   Yamasaki, Masayuki
   Katsube, Takuya
   Sun, Xufeng
   Yamasaki, Yukikazu
   Shiwaku, Kuninori
TI Antiobesity effect of polyphenolic compounds from molokheiya (Corchorus
   olitorius L.) leaves in LDL receptor-deficient mice
SO EUROPEAN JOURNAL OF NUTRITION
LA English
DT Article
DE Corchorus olitorius L.; Molokheiya; Obesity; Oxidative stress;
   beta-oxidation; Polyphenolic compounds
ID HIGH-FAT-DIET; OXIDATIVE STRESS; METABOLIC SYNDROME; PHENOLIC-COMPOUNDS;
   BETA-OXIDATION; LIVER-DISEASE; ACID; EXPRESSION; OBESITY; OXIDASE
AB Dietary supplementation with polyphenolic compounds is associated with reduced diet-induced obesity and metabolic disorders in humans. The antioxidative properties of polyphenolic compounds contribute to their antiobesity effect in animal experiments and human studies.
   The aim of the study was to investigate the antiobesity effect of polyphenolic compounds from molokheiya leaves in LDLR-/- mice fed high-fat diet and to elucidate the mechanism of this effect.
   Three groups of LDLR-/- mice were fed with a high-fat diet, supplemented with 0% (control), 1 or 3% molokheiya leaf powder (MLP). Gene expression in the liver associated with lipid and glucose metabolism was analyzed, and physical parameters and blood biochemistry were determined.
   Compared to controls, mice body weight gain (P = 0.003), liver weight (P = 0.001) and liver triglyceride levels (P = 0.005) were significantly lower in the two MLP groups. Epididymal adipose tissue weight (P = 0.003) was reduced in the 3% MLP group. Liver tissue gene expression of gp91phox (NOX2), involved in oxidative stress, was significantly down-regulated (P = 0.005), and PPAR alpha and CPT1A, related to the activation of beta-oxidation, were significantly up-regulated (P = 0.025 and 0.006, respectively) in the 3% MLP group compared to the control group.
   Our results demonstrate an antiobesity effect of polyphenolic compounds from molokheiya leaves and that this effect is associated with reduction in oxidative stress and enhancement of beta-oxidation in the liver. Consumption of molokheiya leaves may be beneficial for preventing diet-induced obesity.
C1 [Wang, Li; Yamasaki, Masayuki; Sun, Xufeng; Shiwaku, Kuninori] Shimane Univ, Sch Med, Dept Environm & Prevent Med, Izumo, Shimane 6938501, Japan.
   [Katsube, Takuya; Yamasaki, Yukikazu] Shimane Inst Ind Technol, Matsue, Shimane 6900816, Japan.
C3 Shimane University
RP Yamasaki, M (corresponding author), Shimane Univ, Sch Med, Dept Environm & Prevent Med, 89-1 Enya Cho, Izumo, Shimane 6938501, Japan.
EM myamasak@med.shimane-u.ac.jp
FU Japanese Ministry of Education, Culture, Sports, Science and Technology;
   Shimane Prefecture; Shimane Institute for Industrial Technology and
   Izumoya Co. Ltd.
FX This study was supported in part by Grants-in-Aid for Scientific
   Research from the Japanese Ministry of Education, Culture, Sports,
   Science and Technology to M. Yamasaki and Grants for Scientific Research
   from Shimane Prefecture and collaborated with Shimane Institute for
   Industrial Technology and Izumoya Co. Ltd. We thank Dr. Jeff Burgess for
   checking our manuscript.
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Z9 25
U1 1
U2 10
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1436-6207
EI 1436-6215
J9 EUR J NUTR
JI Eur. J. Nutr.
PD MAR
PY 2011
VL 50
IS 2
BP 127
EP 133
DI 10.1007/s00394-010-0122-y
PG 7
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 726TY
UT WOS:000287750300006
PM 20617439
DA 2025-06-11
ER

PT J
AU Codoñer-Franch, P
   Boix-García, L
   Simó-Jordá, R
   del Castillo-Villaescusa, C
   Maset-Maldonado, J
   Valls-Bellés, V
AF Codoner-Franch, Pilar
   Boix-Garcia, Laura
   Simo-Jorda, Raquel
   del Castillo-Villaescusa, Cristina
   Maset-Maldonado, Jesus
   Valls-Belles, Victoria
TI Is obesity associated with oxidative stress in children?
SO INTERNATIONAL JOURNAL OF PEDIATRIC OBESITY
LA English
DT Article
DE Antioxidants; body mass index; children; obesity; oxidative stress
ID ANTIOXIDANT STATUS; HYPERCHOLESTEROLEMIC CHILDREN; LIPID-PEROXIDATION;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; ALPHA-TOCOPHEROL; BETA-CAROTENE;
   OVERWEIGHT; SERUM; GLUTATHIONE
AB Objective. We evaluated the presence of oxidative stress in obese children without co-morbidities. Methods. The study population included 68 children (30 girls, 38 boys), between 6 and 14 years of age. The levels of markers of oxidative damage (malondialdehyde [MDA], and plasma carbonyl groups [CG]) and measures of antioxidant defense, such as the enzyme glutathione peroxidase (GPx) and low molecular scavengers (erythrocyte-reduced glutathione [GSH], alpha-tocopherol and beta-carotene) were determined. Children were categorized in groups by the standard deviation score of body mass index (SDS-BMI). Twenty children were non-obese (SDS-BMI < 1.33), and the 48 obese children (SDS-BMI >= 2) were further divided into two groups: SDS-BMI >= 3 (22 children) and >= 2 SDS-BMI < 3 (26 children). Results. The levels of MDA and CG were significantly higher (p < 0.05) in children with SDS-BMI >= 3. The GPx activity was increased, while the GSH concentration was lower in obese children compared with non-obese children (p < 0.01). There were no differences in serum alpha-tocopherol and beta-carotene levels between groups. MDA was the sole marker of oxidative damage that was positively correlated with SDS-BMI, (r=0.35, p=0.015), and negatively with high-density lipoprotein cholesterol (HDL-C) (r=- 0.32, p=0.027). GPx was inversely related to total cholesterol (r=- 0.34, p=0.019). In multiple regression analysis, we confirmed that SDS-BMI and HDL-C were determinants of MDA. Conclusions. Severe childhood obesity is associated with oxidative stress. Thus, providing foods with high antioxidant capacity in addition to a hypocaloric diet is crucial for the treatment of obese children.</.
C1 [Codoner-Franch, Pilar; Boix-Garcia, Laura; Valls-Belles, Victoria] Univ Valencia, Fac Med & Odontol, Dept POG, Valencia 46010, Spain.
   [Codoner-Franch, Pilar; Simo-Jorda, Raquel; del Castillo-Villaescusa, Cristina; Maset-Maldonado, Jesus] Dr Peset Univ Hosp, Dept Pediat, Valencia, Spain.
C3 University of Valencia
RP Codoñer-Franch, P (corresponding author), Univ Valencia, Fac Med & Odontol, Dept POG, Ave Blasco Ibanez 15, Valencia 46010, Spain.
EM pilar.codoner@uv.es
RI Codoner-Franch, Pilar/K-9333-2014
OI Codoner-Franch, Pilar/0000-0002-1549-1573
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NR 29
TC 71
Z9 77
U1 0
U2 12
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA
SN 1747-7166
J9 INT J PEDIATR OBES
JI Int. J. Pediatr. Obes.
PY 2010
VL 5
IS 1
BP 56
EP 63
DI 10.3109/17477160903055945
PG 8
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA 568PO
UT WOS:000275534900007
PM 19565402
DA 2025-06-11
ER

PT J
AU Gagnadoux, F
   Le Vaillant, M
   Goupil, F
   Pigeanne, T
   Chollet, S
   Masson, P
   Bizieux-Thaminy, A
   Humeau, MP
   Meslier, N
AF Gagnadoux, Frederic
   Le Vaillant, Marc
   Goupil, Francois
   Pigeanne, Thierry
   Chollet, Sylvaine
   Masson, Philippe
   Bizieux-Thaminy, Acya
   Humeau, Marie-Pierre
   Meslier, Nicole
CA IRSR Sleep Cohort Grp
TI Depressive Symptoms Before and After Long-term CPAP Therapy in Patients
   With Sleep Apnea
SO CHEST
LA English
DT Article
ID POSITIVE AIRWAY PRESSURE; QUALITY-OF-LIFE; DAYTIME SLEEPINESS; BREATHING
   DISORDERS; GENERAL-POPULATION; METABOLIC SYNDROME; BLOOD-PRESSURE; IPC
   COHORT; ASSOCIATION; ADULTS
AB Background: The outcome of depressive symptoms under CPAP therapy for OSA-hypopnea syndrome (OSAHS) has been poorly evaluated. In this multicenter, prospective cohort study, we evaluated the prevalence and correlates of persistent depressive symptoms after long-term CPAP therapy for OSAHS.
   Methods: This study included 300 patients with OSAHS and depressive symptoms (13-item, self-rated Pichot depression scale [QD2A] >= 7) at diagnosis. The primary dependent variable was persistent depressive symptoms after >= 1 year of CPAP therapy. Multivariate regression analyses were performed to determine variables independently associated with the persistence of depressive symptoms.
   Results: After an average of 529 days (range, 365-1,569 days) of CPAP therapy, the mean (SD) QD2A score decreased from 9.2 (2.0) to 5.4 (4.0) (P<.0001), but 125 patients (41.7%) presented persistent depressive symptoms. The persistence of depressive symptoms was independently associated with persistent excessive daytime sleepiness (EDS) (OR, 2.72; 95% CI, 1.33-5.61), comorbid cardiovascular disease (OR, 1.76; 95% CI, 1.02-3.00), and female sex (OR, 1.53; 95% CI, 1.09-2.13). A positive linear trend was observed for the adjusted OR of persistent depressive symptoms with decreasing CPAP effect on the Epworth sleepiness scale (P<.0001).
   Conclusions: CPAP therapy does not resolve depressive symptoms in many patients with OSAHS. Persistent depressive symptoms are strongly associated with EDS. Active monitoring of depressive symptoms is needed in patients with OSAHS who are treated with CPAP. Interventional trials are required to evaluate the impact of antidepressants, cognitive behavioral therapy, or both on comorbid depression in patients with OSAHS.
C1 [Gagnadoux, Frederic; Meslier, Nicole] LUNAM Univ, Angers, France.
   [Gagnadoux, Frederic; Meslier, Nicole] Univ Angers, CHU Angers, Dept Pneumol, F-49033 Angers, France.
   [Le Vaillant, Marc] CERMES, CNRS UMR8211, Inserm EHESS U988, Villejuif, France.
   [Goupil, Francois] Ctr Hosp, Serv Pneumol, Le Mans, France.
   [Pigeanne, Thierry] Unite Pneumol, Pole Sante Olonnes, Olonne Sur Mer, France.
   [Chollet, Sylvaine] Hop Laennec, Inst Thorax, Nantes, France.
   [Masson, Philippe] Ctr Hosp, Serv Pneumol, Cholet, France.
   [Bizieux-Thaminy, Acya] Ctr Hosp, Serv Pneumol, La Roche Sur Yon, France.
   [Humeau, Marie-Pierre] Nouvelles Clin Nantaises, Nantes, France.
C3 Universite d'Angers; Centre Hospitalier Universitaire d'Angers; Centre
   National de la Recherche Scientifique (CNRS); CNRS - Institute for
   Humanities & Social Sciences (INSHS); Institut National de la Sante et
   de la Recherche Medicale (Inserm); Universite Paris Cite; Centre
   Hospitalier Le Mans; Nantes Universite; CHU de Nantes; Institut National
   de la Sante et de la Recherche Medicale (Inserm); CHD Vendee
RP Gagnadoux, F (corresponding author), Univ Angers, CHU Angers, Dept Pneumol, 4 Rue Larrey, F-49033 Angers, France.
EM frgagnadoux@chu-angers.fr
RI Masson, Philippe/G-6408-2012
CR Aloia MS, 2005, SLEEP MED, V6, P115, DOI 10.1016/j.sleep.2004.09.003
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NR 41
TC 52
Z9 54
U1 0
U2 5
PU AMER COLL CHEST PHYSICIANS
PI NORTHBROOK
PA 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 USA
SN 0012-3692
J9 CHEST
JI Chest
PD MAY
PY 2014
VL 145
IS 5
BP 1025
EP 1031
DI 10.1378/chest.13-2373
PG 7
WC Critical Care Medicine; Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Respiratory System
GA AI0IZ
UT WOS:000336532100019
PM 24435294
DA 2025-06-11
ER

PT J
AU Braga, SP
   Delanogare, E
   Machado, AE
   Prediger, RD
   Moreira, ELG
AF Braga, Sara Pereira
   Delanogare, Eslen
   Machado, Adriano Emanuel
   Prediger, Rui Daniel
   Gasnhar Moreira, Eduardo Luiz
TI Switching from high-fat feeding (HFD) to regular diet improves metabolic
   and behavioral impairments in middle-aged female mice
SO BEHAVIOURAL BRAIN RESEARCH
LA English
DT Article
DE Obesity; High-fat diet (HFD); Behavioral; Glucose; Depression; Memory
ID INDUCED OBESITY; SYNAPTIC PLASTICITY; NEUROTROPHIC FACTOR;
   INSULIN-RESISTANCE; DEPRESSION; MEMORY; INFLAMMATION; DYSFUNCTION;
   DISORDERS; COGNITION
AB Obesity represents a risk factor for metabolic syndrome and cardiovascular and psychiatric disorders. Excessive caloric intake, particularly in dietary fats, is an environmental factor that contributes to obesity development. Thus, the observation that switching from long-standing dietary obesity to standard diet (SD) can ameliorate the high-fat diet-induced metabolic, memory, and emotionality-related impairments are particularly important. Herein we investigated whether switching from the high-fat diet (HFD) to SD could improve the metabolic and behavioral impairments observed in middle-aged females C57Bl/6 mice. During twelve weeks, the animals received a high-fat diet (61 % fat) or SD diet. After 12-weeks, the HFD group's diet was switched to SD for an additional four weeks. It was observed a progressive deleterious effect of HFD in metabolic and behavioral parameters in mice. After four weeks of HFD-feeding, the animals showed glucose intolerance and increased locomotor activity. A subsequent increase in the body mass gain, hyperglycemia, and depressive-like behavior was observed after eight weeks, and memory impairments after twelve weeks. After replacing the HFD to SD, it was observed an improvement of metabolic (loss of body mass, normal plasma glucose levels, and glucose tolerance) and behavioral (absence of memory and emotional alterations) parameters. These results demonstrate the temporal development of metabolic and behavioral impairments following HFD in middle-age female mice and provide new evidence that these alterations can be improved by switching back the diet to SD.
C1 [Braga, Sara Pereira; Gasnhar Moreira, Eduardo Luiz] Univ Fed Santa Catarina, Programa Multictr Posgrad Ciencias Fisiol, BR-88040900 Florianopolis, SC, Brazil.
   [Delanogare, Eslen; Machado, Adriano Emanuel; Prediger, Rui Daniel; Gasnhar Moreira, Eduardo Luiz] Univ Fed Santa Catarina, Programa Posgrad Neurociencias, BR-88040900 Florianopolis, SC, Brazil.
   [Prediger, Rui Daniel] Univ Fed Santa Catarina, Dept Farmacol, BR-88040900 Florianopolis, SC, Brazil.
   [Gasnhar Moreira, Eduardo Luiz] Univ Fed Santa Catarina, Ctr Ciencias Biol, Dept Ciencias Fisiol, BR-88040900 Florianopolis, SC, Brazil.
C3 Universidade Federal de Santa Catarina (UFSC); Universidade Federal de
   Santa Catarina (UFSC); Universidade Federal de Santa Catarina (UFSC);
   Universidade Federal de Santa Catarina (UFSC)
RP Moreira, ELG (corresponding author), Univ Fed Santa Catarina, Ctr Ciencias Biol, Dept Ciencias Fisiol, BR-88040900 Florianopolis, SC, Brazil.
EM eduardo.luiz@ufsc.br
RI Machado, Adriano/KHE-3669-2024; Prediger, Rui/AAV-3419-2020; Moreira,
   Eduardo/N-6420-2014; Prediger, Rui/C-4036-2013; Gasnhar Moreira, Eduardo
   Luiz/S-6205-2016
OI Prediger, Rui/0000-0002-7547-6463; Gasnhar Moreira, Eduardo
   Luiz/0000-0003-2306-2207; Machado, Adriano/0000-0003-2305-1639
FU CAPES; CNPq [Universal 424799/2018-9]; FAPESC
FX The authors declare that they have no conflicts of interest. Research
   supported by grants from the Brazilian funding agencies CAPES, CNPq
   (Universal 424799/2018-9) and FAPESC. RDP is recipient of CNPq
   fellowship.
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NR 56
TC 10
Z9 13
U1 0
U2 14
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0166-4328
EI 1872-7549
J9 BEHAV BRAIN RES
JI Behav. Brain Res.
PD FEB 1
PY 2021
VL 398
AR 112969
DI 10.1016/j.bbr.2020.112969
PG 9
WC Behavioral Sciences; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Behavioral Sciences; Neurosciences & Neurology
GA PE5EQ
UT WOS:000598389300009
PM 33075395
DA 2025-06-11
ER

PT J
AU Sayana, P
   Colpo, GD
   Simoes, LR
   Giridharan, VV
   Teixeira, AL
   Quevedo, J
   Barichello, T
AF Sayana, Pavani
   Colpo, Gabriela Delevati
   Simoes, Lutiana R.
   Giridharan, Vijayasree Vayalanellore
   Teixeira, Antonio Lucio
   Quevedo, Joao
   Barichello, Tatiana
TI A systematic review of evidence for the role of inflammatory biomarkers
   in bipolar patients
SO JOURNAL OF PSYCHIATRIC RESEARCH
LA English
DT Review
DE Inflammation; Bipolar disorder; Mania; Depression; Biomarkers
ID C-REACTIVE PROTEIN; NECROSIS-FACTOR-ALPHA; MAJOR DEPRESSIVE DISORDER;
   INCREASED PLASMA-LEVELS; CYTOKINE LEVELS; I DISORDER; METABOLIC
   SYNDROME; SERUM-LEVELS; ANTIINFLAMMATORY CYTOKINES; UNIPOLAR DEPRESSION
AB Bipolar disorder (BD) is a neuropsychiatric disorder that is characterized by a phasic course of affective episodes interspersed with a euthymic state. Epidemiological, clinical, genetic, post-mortem and pre Accepted clinical studies have shown that inflammatory reactions and immune modulation play a pivotal role in the pathophysiology of BD. It is conceptualized that biomarkers of inflammation and immune responses should be employed to monitor the disease process in bipolar patients. The objective of this systematic review is to analyse the inflammatory markers involved in human studies and to explore each individual marker for its potential clinical application and summarize evidence regarding their role in BD. A systematic review of human studies to measure inflammatory markers was conducted, and the studies were identified by searching PubMed/MEDLINE, PsycINFO, EMBASE, and Web of Science databases for peer reviewed journals that were published until September 2015. In this review, we included peripheral markers, genetic, post-mortem and cell studies with inflammatory biomarker analysis in BD. One hundred and two (102) papers met the inclusion criteria. The pro-inflammatory cytokines were elevated and the anti-inflammatory cytokines were reduced in BD patients, particularly during manic and depressive phases when compared to the controls. These changes tend to disappear in euthymia, indicating that inflammation may be associated with acute phases of BD. Even though there are promising findings in this field, further clinical studies using more established detection techniques are needed to clearly show the benefit of using inflammatory markers in the diagnosis, follow-up and prognosis of patients with BD. (C) 2017 Elsevier Ltd. All rights reserved.
C1 [Sayana, Pavani; Colpo, Gabriela Delevati; Giridharan, Vijayasree Vayalanellore; Teixeira, Antonio Lucio; Quevedo, Joao; Barichello, Tatiana] Univ Texas Hlth Sci Ctr Houston, Translat Psychiat Program, Dept Psychiat & Behav Sci, McGovern Med Sch, Houston, TX 77030 USA.
   [Quevedo, Joao] Univ Texas Hlth Sci Ctr Houston, Ctr Excellence Mood Disorders, Dept Psychiat & Behav Sci, McGovern Med Sch, Houston, TX 77030 USA.
   [Quevedo, Joao; Barichello, Tatiana] Univ Texas Grad Sch Biomed Sci Houston, Neurosci Grad Program, Houston, TX USA.
   [Simoes, Lutiana R.; Quevedo, Joao; Barichello, Tatiana] Univ Southern Santa Catarina, Lab Neurosci, Grad Program Hlth Sci, Hlth Sci Unit,UNESC, Criciuma, SC, Brazil.
C3 University of Texas System; University of Texas Health Science Center
   Houston; Baylor College of Medicine; Baylor College Medical Hospital;
   Baylor College of Medicine; Baylor College Medical Hospital; University
   of Texas System; University of Texas Health Science Center Houston;
   University of Texas System; University of Texas Health Science Center
   Houston; University of Texas Graduate School of Biomedical Sciences;
   Universidade do Sul de Santa Catarina
RP Barichello, T (corresponding author), Univ Texas Hlth Sci Ctr Houston, Dept Psychiat & Behav Sci, 1941 East Rd, Houston, TX 77054 USA.
EM Tatiana.Barichello@uth.tmc.edu
RI Barichello, Tatiana/E-2725-2013; Simões, Lutiana/I-9896-2014;
   Giridharan, Vijayasree/ABD-6290-2020; Teixeira, Antonio/N-3315-2014; de
   Quevedo, Joao Luciano/E-5491-2013
OI V Giridharan, Vijayasree/0000-0003-3069-7139; de Quevedo, Joao
   Luciano/0000-0003-3114-6611; Teixeira, Antonio
   Lucio/0000-0002-9621-5422; Delevati Colpo, Gabriela/0000-0003-2023-6902;
   Barichello, Tatiana/0000-0001-7776-8454
FU Department of Psychiatry and Behavioral Sciences, McGovern Medical
   School, The University of Texas Health Science Center at Houston
   (UTHealth); National Council for Scientific and Technological
   Development [CNPq/443826/2014-5]; Foundation for Research and Innovation
   of the State of Santa Catarina [FAPESC1079/2016]; Institute Cerebro e
   Mente; UNESC
FX The Translational Psychiatry Program (USA) is funded by the Department
   of Psychiatry and Behavioral Sciences, McGovern Medical School, The
   University of Texas Health Science Center at Houston (UTHealth). The
   Laboratory of Neurosciences (Brazil) is one of the centres of the
   National Institute for Molecular Medicine (INCT-MM) and one of the
   members of the Centre of Excellence in Applied Neurosciences of Santa
   Catarina (NENASC). Its research is supported by grants from the National
   Council for Scientific and Technological Development
   (CNPq/443826/2014-5) (JQ, TB and ALT), the Foundation for Research and
   Innovation of the State of Santa Catarina (FAPESC1079/2016) (IQ and TB),
   and the Institute Cerebro e Mente (JQ) and UNESC (JQ and TB).
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NR 111
TC 136
Z9 141
U1 1
U2 30
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-3956
EI 1879-1379
J9 J PSYCHIATR RES
JI J. Psychiatr. Res.
PD SEP
PY 2017
VL 92
BP 160
EP 182
DI 10.1016/j.jpsychires.2017.03.018
PG 23
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA EZ4RV
UT WOS:000404701100020
PM 28458141
DA 2025-06-11
ER

PT J
AU Bartoli, F
   Crocamo, C
   Mazza, MG
   Clerici, M
   Carrà, G
AF Bartoli, Francesco
   Crocamo, Cristina
   Mazza, Mario Gennaro
   Clerici, Massimo
   Carra, Giuseppe
TI Uric acid levels in subjects with bipolar disorder: A comparative
   meta-analysis
SO JOURNAL OF PSYCHIATRIC RESEARCH
LA English
DT Review
DE Bipolar disorder; Uric acid; Meta-analysis; Mania; Purinergic system;
   Adenosine
ID METABOLIC SYNDROME; DIFFERENT PHASES; MOOD DISORDERS; DOUBLE-BLIND;
   PURINERGIC SYSTEM; CONTROLLED-TRIAL; SCHIZOPHRENIA; ALLOPURINOL; MANIA;
   HYPERURICEMIA
AB Previous research has hypothesised increased uric acid levels, possibly because of an amplified purinergic metabolism and a reduced adenosine activity, in subjects with bipolar disorder. This systematic review and meta-analysis aimed at estimating if individuals with bipolar disorder had uric acid levels higher than both healthy controls and subjects with major depression (trait marker hypothesis). It also tested if uric acid levels could differ in different phases of bipolar disorder (state marker hypothesis). Meta-analyses were carried out generating pooled standardized mean differences (SMDs), using random-effects models. Heterogeneity between studies was estimated using the 12 index. Relevant sensitivity and meta-regression analyses were conducted.
   We searched main Electronic Databases, identifying twelve studies that met our inclusion criteria. Meta-analyses showed increased uric acid levels in individuals with bipolar disorder as compared with both healthy controls (SMD = 0.65, p < 0.001, I-2 = 82.9%) and those with major depression (SMD = 0.46, p < 0.001; 12 = 68.7%). However, meta-regression analyses confirmed this association only as compared with healthy controls. Finally, though uric acid levels were higher in manic/mixed phases as compared with depressive ones (SMD = 0.34; p = 0.04, I-2 = 58.8%), a sensitivity analysis did not confirm the association.
   In sum, our meta-analysis shows that subjects with bipolar disorder have uric acid levels higher than healthy controls. The potential role of factors that might clarify the nature of this association deserves additional research. (C) 2016 Elsevier Ltd. All rights reserved.
C1 [Bartoli, Francesco; Crocamo, Cristina; Mazza, Mario Gennaro; Clerici, Massimo; Carra, Giuseppe] Univ Milano Bicocca, Dept Med & Surg, Milan, Italy.
   [Carra, Giuseppe] UCL, Div Psychiat, London W1T 7NF, England.
C3 University of Milano-Bicocca; University of London; University College
   London
RP Bartoli, F (corresponding author), Univ Milano Bicocca, Dept Med & Surg, Via Cadore 48, I-20900 Monza, MB, Italy.
EM f.bartoli@campus.unimib.it
RI Crocamo, Cristina/I-4355-2019; Clerici, Massimo/U-3074-2019; Mazza,
   Mario/W-4083-2019; Bartoli, Francesco/K-5755-2016; Carra,
   Giuseppe/C-6091-2012; Crocamo, Cristina/B-5404-2014
OI Clerici, Massimo/0000-0001-8769-6474; Bartoli,
   Francesco/0000-0003-2612-4119; Mazza, Mario Gennaro/0000-0001-6613-2477;
   Carra, Giuseppe/0000-0002-6877-6169; Crocamo,
   Cristina/0000-0002-2979-2107
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NR 47
TC 67
Z9 71
U1 4
U2 28
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-3956
EI 1879-1379
J9 J PSYCHIATR RES
JI J. Psychiatr. Res.
PD OCT
PY 2016
VL 81
BP 133
EP 139
DI 10.1016/j.jpsychires.2016.07.007
PG 7
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA DY1LB
UT WOS:000384855400018
PM 27442964
DA 2025-06-11
ER

PT J
AU Hirayama, A
   Torimoto, K
   Mastusita, C
   Okamoto, N
   Morikawa, M
   Tanaka, N
   Fujimoto, K
   Yoshida, K
   Hirao, Y
   Kurumatani, N
AF Hirayama, Akihide
   Torimoto, Kazumasa
   Mastusita, Chie
   Okamoto, Nozomi
   Morikawa, Masayuki
   Tanaka, Nobumichi
   Fujimoto, Kiyohide
   Yoshida, Kastunori
   Hirao, Yoshihiko
   Kurumatani, Norio
TI Risk Factors for New-onset Overactive Bladder in Older Subjects: Results
   of the Fujiwara-Kyo Study
SO UROLOGY
LA English
DT Article
ID URINARY-TRACT SYMPTOMS; POPULATION-BASED SURVEY; LIFE-STYLE FACTORS;
   ALCOHOL-CONSUMPTION; CIGARETTE-SMOKING; PHYSICAL-ACTIVITY; INCONTINENCE;
   ASSOCIATION; PREVALENCE; HEALTH
AB OBJECTIVE To evaluate the risk factors for new-onset overactive bladder (OAB) in older subjects.
   METHODS The present study enrolled 4427 subjects aged >= 65 years who had participated in the Fujiwarakyo study. The prevalence of OAB at baseline and 1 year later was evaluated using the OAB symptom score questionnaire. The incidence and remission rate of OAB were calculated. We identified the risk factors for OAB by evaluating the difference in characteristics (including sex, age, body mass index, life style, comorbidities, depressive status, metabolic syndrome, and sum of voiding symptoms) between those with and without new-onset OAB. In addition, the independent risk factors were determined by multivariate analysis.
   RESULTS Of the 4427 subjects, 3685 completely replied to the self-administrated questionnaires at baseline and 1 year later. The incidence and remission rate of OAB was 11.9% and 29.8%, respectively. The male/female ratio, sum of voiding symptoms, alcohol consumption and smoking, hypertension, and depressive status in subjects with new-onset OAB, were significantly greater than those in subjects without new-onset OAB. A multivariate analysis, including sex (odds ratio 2.0, P < .0001), sum of voiding symptoms (odds ratio 1.1, P < .0001), and depressive status (odds ratio 1.8, P < .0001) were independent factors for new-onset OAB in older subjects.
   CONCLUSION The results of the present study have demonstrated that male sex, the sum of voiding symptoms, and depression were independent factors for new-onset OAB. It is necessary to determine whether the treatment of patients with voiding symptoms or depression controls for new-onset OAB. UROLOGY 80: 71-76, 2012. (c) 2012 Elsevier Inc.
C1 [Hirayama, Akihide] Nara Med Univ, Dept Urol, Kashihara, Nara 6348522, Japan.
   Nara Med Univ, Dept Community Hlth & Epidemiol, Kashihara, Nara 6348522, Japan.
   Nara Med Univ, Dept Psychiat, Kashihara, Nara 6348522, Japan.
C3 Nara Medical University; Nara Medical University; Nara Medical
   University
RP Hirayama, A (corresponding author), Nara Med Univ, Dept Urol, 840 Shijo Cho, Kashihara, Nara 6348522, Japan.
EM hirayamn@naramed-u.ac.jp
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NR 30
TC 37
Z9 38
U1 0
U2 3
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0090-4295
EI 1527-9995
J9 UROLOGY
JI Urology
PD JUL
PY 2012
VL 80
IS 1
BP 71
EP 76
DI 10.1016/j.urology.2012.04.019
PG 6
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 968DP
UT WOS:000305957500021
PM 22626577
DA 2025-06-11
ER

PT J
AU Simon, MS
   Burger, B
   Weidinger, E
   Arteaga-Henríquez, G
   Zill, P
   Musil, R
   Drexhage, HA
   Müller, N
AF Simon, Maria S.
   Burger, Bianka
   Weidinger, Elif
   Arteaga-Henriquez, Gara
   Zill, Peter
   Musil, Richard
   Drexhage, Hemmo A.
   Mueller, Norbert
TI Efficacy of Sertraline Plus Placebo or Add-On Celecoxib in Major
   Depressive Disorder: Macrophage Migration Inhibitory Factor as a
   Promising Biomarker for Remission After Sertraline-Results From a
   Randomized Controlled Clinical Trial
SO FRONTIERS IN PSYCHIATRY
LA English
DT Article
DE inflammatory; Major depressive disorder; cytokine; response; biomarker;
   anti-inflammatory treatment
ID CARDIOVASCULAR RISK-FACTORS; TUMOR-NECROSIS-FACTOR;
   CORONARY-HEART-DISEASE; C-REACTIVE PROTEIN; DOUBLE-BLIND; METABOLIC
   SYNDROME; SERUM-LEVELS; FACTOR-ALPHA; INFLAMMATION; METAANALYSIS
AB Introduction: Previous research delivers strong indications that inflammatory activation leads to treatment resistance in a subgroup of patients with Major Depressive Disorder (MDD). Thus, tailored interventions are needed. The present study aimed to find potential biomarkers that may enable patients to be stratified according to immune activation.</p>
   Methods: A phase IIa randomized placebo-controlled trial was performed to assess levels of inflammatory compounds in responders/remitters and non-responders/non-remitters to sertraline plus celecoxib (n = 20) and sertraline plus placebo (n = 23). Levels of macrophage migration inhibitory factor, neopterin, and tumor necrosis factor alpha were determined by enzyme-linked immunosorbent assay; response and remission were measured by reduction of the Montgomery & ANGS;sberg Depression Rating Scale score.</p>
   Results: Both treatment groups showed a significant decline in depression symptoms, but no difference was found between groups. A clear pattern emerged only for macrophage migration inhibitory factor: placebo remitters showed significantly lower baseline levels than non-remitters (a similar trend was seen in responders and non-responders) while celecoxib responders showed a trend for higher baseline levels than non-responders.</p>
   Conclusion: Small subsample sizes are a notable limitation, wherefore results are preliminary. However, the present study provides novel insights by suggesting macrophage migration inhibitory factor as a promising biomarker for treatment choice.</p>
C1 [Simon, Maria S.; Weidinger, Elif; Zill, Peter; Musil, Richard; Mueller, Norbert] Ludwig Maximilians Univ Munchen, Univ Hosp, Dept Psychiat & Psychotherapy, Munich, Germany.
   [Burger, Bianka] Marion von Tessin Memory Ctr, Munich, Germany.
   [Arteaga-Henriquez, Gara] Hosp Univ Vall dHebron, Vall dHebron Res Inst VHIR, Dept Psychiat, Vall dHebron Barcelona Hosp Campus, Barcelona, Spain.
   [Arteaga-Henriquez, Gara] Biomed Network Res Ctr Mental Hlth CIBERSAM, Madrid, Spain.
   [Drexhage, Hemmo A.] Erasmus MC, Dept Immunol, Rotterdam, Netherlands.
C3 University of Munich; Autonomous University of Barcelona; Hospital
   Universitari Vall d'Hebron; Vall d'Hebron Institut de Recerca (VHIR);
   CIBER - Centro de Investigacion Biomedica en Red; CIBERSAM; Erasmus
   University Rotterdam; Erasmus MC
RP Simon, MS (corresponding author), Ludwig Maximilians Univ Munchen, Univ Hosp, Dept Psychiat & Psychotherapy, Munich, Germany.
EM maria.simon@med.uni-menchen.de
RI Musil, Richard/AAF-4331-2020
FU EU 7th Framework program
   [EU-FP7-CP-IP-2008-222963/EU-FP7-PEOPLE-2009-IAPP-MarieCurie-286334];
   Horizon 2020 [H2020-SC1-2016-2017/H2020-SC1-2017-Two-Stage-RTD];
   foundation Immunitaet und Seele
FX & nbsp;This present work was funded by the EU 7th Framework program
   (grant number
   EU-FP7-CP-IP-2008-222963/EU-FP7-PEOPLE-2009-IAPP-MarieCurie-286334) and
   Horizon 2020 (grant number
   H2020-SC1-2016-2017/H2020-SC1-2017-Two-Stage-RTD). Further, part of this
   work was supported by the foundation Immunitaet und Seele. The funders
   had no role in the study design, data collection and analysis, or
   decision to publish.
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NR 75
TC 15
Z9 15
U1 0
U2 7
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-0640
J9 FRONT PSYCHIATRY
JI Front. Psychiatry
PD SEP 27
PY 2021
VL 12
AR 615261
DI 10.3389/fpsyt.2021.615261
PG 11
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA WV8YG
UT WOS:000717515600001
PM 34646168
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Lasaite, L
   Ceponis, J
   Preiksa, RT
   Zilaitiene, B
AF Lasaite, L.
   Ceponis, J.
   Preiksa, R. T.
   Zilaitiene, B.
TI Impaired emotional state, quality of life and cognitive functions in
   young hypogonadal men
SO ANDROLOGIA
LA English
DT Article
DE Cognitive functions; emotional state; quality of life; young hypogonadal
   men
ID TESTOSTERONE REPLACEMENT THERAPY; ERECTILE DYSFUNCTION; METABOLIC
   SYNDROME; HORMONES; DEPRESSION; DENSITY; ASSOCIATION; PREVALENCE;
   DEFICIENCY; MALES
AB The study aimed to analyse emotional state, quality of life and cognitive functions in young hypogonadal men. Thirty-four males with hypogonadism (age 29.1 +/- 10.5years) and 34 age-matched healthy males (age 30.5 +/- 11.0years) were recruited. Their emotional state was evaluated by Profile of Mood States, quality of life - by WHO Brief Quality of Life Questionnaire - and cognitive functioning - by Trail Making Test and Digit Span Test of Wechsler Adult Intelligence Scale. It was found that young men with hypogonadism had higher depression-dejection (13.1 +/- 8.8 versus 7.4 +/- 5.9, P=0.003), fatigue-inertia (10.0 +/- 5.8 versus 7.0 +/- 4.9, P=0.030), confusion-bewilderment (5.1 +/- 4.6 versus 2.3 +/- 3.1, P=0.004) and lower vigour-activity (14.3 +/- 5.1 versus 17.7 +/- 4.3, P=0.008) levels than age- and sex-matched controls. Quality of life psychological (13.1 +/- 2.8 versus 15.1 +/- 1.9, P=0.005) and social (13.6 +/- 2.4 versus 15.7 +/- 2.0, P<0.001) domains were significantly worse in men with hypogonadism than in controls. Cognitive functions were significantly worse (P<0.001) in men with hypogonadism than in controls, showing worse executive function, attention, visual scanning abilities and psychomotor speed. A significant correlation was found between testosterone concentration and quality of life psychological domain. Cognitive functioning scores were significantly related with FT4 concentration. It is concluded that young hypogonadal patients have impaired emotional state and quality of life, but the most severe impairment was found in cognitive functioning.
C1 [Lasaite, L.; Ceponis, J.; Preiksa, R. T.; Zilaitiene, B.] Lithuanian Univ Hlth Sci, Inst Endocrinol, Kaunas, Lithuania.
C3 Lithuanian University of Health Sciences
RP Lasaite, L (corresponding author), LSMU, Inst Endocrinol, Eiveniu 2, LT-50009 Kaunas, Lithuania.
EM linlasla@yahoo.com
RI Ceponis, Jonas/NIU-5171-2025
OI Ceponis, Jonas/0000-0003-4261-5014
CR Amiaz R, 2008, CURR OPIN ENDOCRINOL, V15, P278, DOI 10.1097/MED.0b013e3282fc27eb
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NR 34
TC 31
Z9 33
U1 0
U2 12
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0303-4569
EI 1439-0272
J9 ANDROLOGIA
JI Andrologia
PD DEC
PY 2014
VL 46
IS 10
BP 1107
EP 1112
DI 10.1111/and.12199
PG 6
WC Andrology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism
GA AT4MQ
UT WOS:000344913900004
PM 24313565
OA gold
DA 2025-06-11
ER

PT J
AU Nath, M
   Bhattacharjee, K
   Choudhury, Y
AF Nath, Moumita
   Bhattacharjee, Kasturi
   Choudhury, Yashmin
TI Vildagliptin, a dipeptidyl peptidase-4 inhibitor, reduces betel-nut
   induced carcinogenesis in female mice
SO LIFE SCIENCES
LA English
DT Article
DE Akt-mTOR; AMPK signaling; Betel-nut; Carcinogenesis; Drug repurposing;
   Vildagliptin
ID HIGH-FAT DIET; HEPATOCELLULAR-CARCINOMA; METABOLIC SYNDROME; OXIDATIVE
   STRESS; BREAST-CANCER; EXPRESSION; ACTIVATION; CELLS; AMPK; RISK
AB Aim: Betel-nut, a popular masticatory among Southeast Asian populations is a class I carcinogen, previously associated with dyslipidemia and aberrant lipid metabolism, and is reported to be used more frequently by females, than males. This study investigates the potential of repurposing the anti-diabetic drug, vildagliptin, a dipeptidyl peptidase-4 inhibitor, for alleviating the oncogenic condition in female Swiss Albino mice administered an aqueous extract of betel-nut (AEBN) orally (2 mg ml(-1)) for 24 weeks.
   Main methods: Tissues were investigated by histopathological, immunohistochemical and apoptosis assays. Biochemical analyses of oxidative stress markers and lipid profile were performed using different tissues and sera. The expressions of different proteins involved in lipid metabolism and oncogenic pathways were evaluated by Western blotting.
   Key findings: AEBN induced carcinogenesis primarily in the liver by significantly impairing AMPK signaling, inducing oxidative stress, activating Akt/mTOR signaling, increasing Ki-67 immunoreactivity and cyclin D1 expression, and significantly diminishing apoptosis. Co-administration of AEBN with vildagliptin (10 mg kg(-1) body weight) for 8 weeks reduced liver dysplasia, and significantly decreased free palmitic acid, increased free oleic acid, normalized lipid profile, decreased oxidative stress, cyclin D1 expression, Ki-67 immunoreactivity, and Bcl2 expression, and increased the ratio of apoptotic/non-apoptotic cells. Mechanistically, vildagliptin elicited these physiological and molecular alterations by restoring normal AMPK signaling and reducing the cellular expressions of FASN and HMGCR, restoring AMPK-dependent phosphorylation of p53 at Ser-15 and reducing Akt/mTOR signaling.
   Significance: These results indicate that vildagliptin may alleviate betel-nut induced carcinogenesis in the liver of female mice.
C1 [Nath, Moumita; Bhattacharjee, Kasturi; Choudhury, Yashmin] Assam Univ, Dept Biotechnol, Silchar 788011, Assam, India.
C3 Assam University
RP Choudhury, Y (corresponding author), Assam Univ, Dept Biotechnol, Silchar 788011, Assam, India.
EM yashminchoudhury@aus.ac.in
RI Choudhury, Yashmin/AAC-5778-2019
FU DBT, Government of India [BT/567/NE/U-Excel/2016]; DST-INSPIRE
   Fellowship from DST, Government of India
FX This study was funded by grant sanction no. BT/567/NE/U-Excel/2016 dated
   31st March 2017, from DBT, Government of India to Yashmin Choudhury.
   Moumita Nath is a recipient of the DST-INSPIRE Fellowship from DST,
   Government of India.
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NR 72
TC 5
Z9 5
U1 1
U2 6
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0024-3205
EI 1879-0631
J9 LIFE SCI
JI Life Sci.
PD FEB 1
PY 2021
VL 266
AR 118870
DI 10.1016/j.lfs.2020.118870
PG 13
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA PV5TE
UT WOS:000610049400017
PM 33310040
DA 2025-06-11
ER

PT J
AU Du, JJ
   Fan, LM
   Mai, A
   Li, JM
AF Du, Junjie
   Fan, Lampson M.
   Mai, Anna
   Li, Jian-Mei
TI Crucial roles of Nox2-derived oxidative stress in deteriorating the
   function of insulin receptors and endothelium in dietary obesity of
   middle-aged mice
SO BRITISH JOURNAL OF PHARMACOLOGY
LA English
DT Article
DE obesity; insulin resistance; ageing; endothelial dysfunction; Nox2
   inhibitor; NADPH oxidase; oxidative stress
ID NITRIC-OXIDE SYNTHASE; NADPH OXIDASE; P47(PHOX) PHOSPHORYLATION;
   ANGIOTENSIN-II; NOX2; FAT; DYSFUNCTION; RESISTANCE; INFLAMMATION;
   OVERWEIGHT
AB Background and PurposeSystemic oxidative stress associated with dietary calorie overload plays an important role in the deterioration of vascular function in middle-aged patients suffering from obesity and insulin resistance. However, effective therapy is still lacking.
   Experimental ApproachIn this study, we used a mouse model of middle-aged obesity to investigate the therapeutic potential of pharmaceutical inhibition (apocynin, 5mM supplied in the drinking water) or knockout of Nox2, an enzyme generating reactive oxygen species (ROS), in high-fat diet (HFD)-induced obesity, oxidative stress, insulin resistance and endothelial dysfunction. Littermates of C57BL/6J wild-type (WT) and Nox2 knockout (KO) mice (7 months old) were fed with a HFD (45% kcal fat) or normal chow diet (NCD, 12% kcal fat) for 16 weeks and used at 11 months of age.
   Key ResultsCompared to NCD WT mice, HFD WT mice developed obesity, insulin resistance, dyslipidaemia and hypertension. Aortic vessels from these mice showed significantly increased Nox2 expression and ROS production, accompanied by significantly increased ERK1/2 activation, reduced insulin receptor expression, decreased Akt and eNOS phosphorylation and impaired endothelium-dependent vessel relaxation to acetylcholine. All these HFD-induced abnormalities (except the hyperinsulinaemia) were absent in apocynin-treated WT or Nox2 KO mice given the same HFD.
   Conclusions and ImplicationsIn conclusion, Nox2-derived ROS played a key role in damaging insulin receptor and endothelial function in dietary obesity after middle-age. Targeting Nox2 could represent a valuable therapeutic strategy in the metabolic syndrome.
C1 [Du, Junjie; Mai, Anna; Li, Jian-Mei] Univ Surrey, Fac Hlth & Med Sci, Guildford GU2 7XH, Surrey, England.
   [Fan, Lampson M.] Univ Oxford, John Radcliffe Hosp, Oxford OX3 9DU, England.
C3 University of Surrey; University of Oxford
RP Li, JM (corresponding author), Univ Surrey, Fac Hlth & Med Sci, AY Bldg, Guildford GU2 7XH, Surrey, England.
EM j.li@surrey.ac.uk
FU University of Surrey Overseas Research Student Award Scheme
FX J. D. was supported by the University of Surrey Overseas Research
   Student Award Scheme.
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NR 45
TC 59
Z9 62
U1 0
U2 12
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0007-1188
EI 1476-5381
J9 BRIT J PHARMACOL
JI Br. J. Pharmacol.
PD NOV
PY 2013
VL 170
IS 5
BP 1064
EP 1077
DI 10.1111/bph.12336
PG 14
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 238VF
UT WOS:000325978800011
PM 23957783
OA Green Published
DA 2025-06-11
ER

PT J
AU Hasegawa, Y
   Saito, T
   Ogihara, T
   Ishigaki, Y
   Yamada, T
   Imai, J
   Uno, K
   Gao, JH
   Kaneko, K
   Shimosawa, T
   Asano, T
   Fujita, T
   Oka, Y
   Katagiri, H
AF Hasegawa, Yutaka
   Saito, Tokuo
   Ogihara, Takehide
   Ishigaki, Yasushi
   Yamada, Tetsuya
   Imai, Junta
   Uno, Kenji
   Gao, Junhong
   Kaneko, Keizo
   Shimosawa, Tatsuo
   Asano, Tomoichiro
   Fujita, Toshiro
   Oka, Yoshitomo
   Katagiri, Hideki
TI Blockade of the Nuclear Factor-κB Pathway in the Endothelium Prevents
   Insulin Resistance and Prolongs Life Spans
SO CIRCULATION
LA English
DT Article
DE inflammation; insulin resistance; oxidative stress; NF-kappa B
ID MICE LACKING; MITOCHONDRIAL DYSFUNCTION; CALORIE RESTRICTION;
   INFLAMMATION; OBESITY; HYPERTENSION; MECHANISMS; ATHEROSCLEROSIS;
   ACCUMULATION; INVOLVEMENT
AB Background-Nuclear factor-kappa B (NF-kappa B) signaling plays critical roles in physiological and pathological processes such as responses to inflammation and oxidative stress.
   Methods and Results-To examine the role of endothelial NF-kappa B signaling in vivo, we generated transgenic mice expressing dominant-negative I kappa B under the Tie2 promoter/enhancer (E-DNI kappa B mice). These mice exhibited functional inhibition of NF-kappa B signaling specifically in endothelial cells. Although E-DNI kappa B mice displayed no overt phenotypic changes when young and lean, they were protected from the development of insulin resistance associated with obesity, whether diet-or genetics-induced. Obesity-induced macrophage infiltration into adipose tissue and plasma oxidative stress markers were decreased and blood flow and mitochondrial content in muscle and active-phase locomotor activity were increased in E-DNI kappa B mice. In addition to inhibition of obesity-related metabolic deteriorations, blockade of endothelial NF-kappa B signaling prevented age-related insulin resistance and vascular senescence and, notably, prolonged life span. These antiaging phenotypes were also associated with decreased oxidative stress markers, increased muscle blood flow, enhanced active-phase locomotor activity, and aortic upregulation of mitochondrial sirtuin-related proteins.
   Conclusions-The endothelium plays important roles in obesity-and age-related disorders through intracellular NF-kappa B signaling, thereby ultimately affecting life span. Endothelial NF-kappa B signaling is a potential target for treating the metabolic syndrome and for antiaging strategies. (Circulation. 2012;125:1122-1133.)
C1 [Katagiri, Hideki] Tohoku Univ, Grad Sch Med, Dept Metab Dis, Ctr Metab Dis,Aoba Ku, Sendai, Miyagi 9808575, Japan.
   [Hasegawa, Yutaka; Saito, Tokuo; Ishigaki, Yasushi; Imai, Junta; Uno, Kenji; Kaneko, Keizo; Oka, Yoshitomo] Tohoku Univ, Grad Sch Med, Div Mol Metab & Diabet, Sendai, Miyagi 9808575, Japan.
   [Shimosawa, Tatsuo] Univ Tokyo, Fac Med, Dept Clin Lab, Tokyo 113, Japan.
   [Fujita, Toshiro] Univ Tokyo, Fac Med, Dept Nephrol & Endocrinol, Tokyo 113, Japan.
   [Asano, Tomoichiro] Hiroshima Univ, Dept Med Sci, Grad Sch Med, Hiroshima, Japan.
C3 Tohoku University; Tohoku University; University of Tokyo; University of
   Tokyo; Hiroshima University
RP Katagiri, H (corresponding author), Tohoku Univ, Grad Sch Med, Dept Metab Dis, Ctr Metab Dis,Aoba Ku, 2-1 Seiryo Machi, Sendai, Miyagi 9808575, Japan.
EM katagiri@med.tohoku.ac.jp
RI Shimosawa, Tatsuo/A-2920-2015; Imai, Junta/NFG-4543-2025
FU Japan Society for the Promotion of Science of Japan [15390282,
   22790681]; Ministry of Education, Culture, Sports, Science, and
   Technology of Japan; Grants-in-Aid for Scientific Research [22126006,
   15390282, 23591213, 24790733, 21390261, 23390238, 21229012, 23791012,
   24659439, 23591293, 23791011, 22790681] Funding Source: KAKEN
FX This work was supported by Grants-in-Aid for Scientific Research
   (15390282) to Dr Katagiri and (22790681) to Dr Hasegawa from the Japan
   Society for the Promotion of Science of Japan. This work was also
   supported by a Grant-in-Aid for Scientific Research on Innovative Areas
   (to Dr Katagiri) and the Global-COE (to Drs Katagiri and Oka) from the
   Ministry of Education, Culture, Sports, Science, and Technology of
   Japan.
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NR 50
TC 143
Z9 156
U1 0
U2 13
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0009-7322
EI 1524-4539
J9 CIRCULATION
JI Circulation
PD MAR 6
PY 2012
VL 125
IS 9
BP 1122
EP U140
DI 10.1161/CIRCULATIONAHA.111.054346
PG 31
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 904LK
UT WOS:000301197700019
PM 22302838
OA Bronze
DA 2025-06-11
ER

PT J
AU Doyle, K
   Fitzpatrick, FA
AF Doyle, Kelly
   Fitzpatrick, F. A.
TI Redox Signaling, Alkylation (Carbonylation) of Conserved Cysteines
   Inactivates Class I Histone Deacetylases 1, 2, and 3 and Antagonizes
   Their Transcriptional Repressor Function
SO JOURNAL OF BIOLOGICAL CHEMISTRY
LA English
DT Article
ID LIPID-PEROXIDATION PRODUCT; KAPPA-B KINASE;
   15-DEOXY-DELTA(12,14)-PROSTAGLANDIN J(2); CYCLOPENTENONE PROSTAGLANDINS;
   PROTEIN CARBONYLATION; GROWTH-INHIBITION; COVALENT MODIFICATION;
   OXIDATIVE STRESS; INFLAMMATION; MECHANISM
AB Cells use redox signaling to adapt to oxidative stress. For instance, certain transcription factors exist in a latent state that may be disrupted by oxidative modifications that activate their transcription potential. We hypothesized that DNA-binding sites (response elements) for redox-sensitive transcription factors may also exist in a latent state, maintained by co-repressor complexes containing class I histone deacetylase (HDAC) enzymes, and that HDAC inactivation by oxidative stress may antagonize deacetylase activity and unmask electrophile-response elements, thus activating transcription. Electrophiles suitable to test this hypothesis include reactive carbonyl species, often derived from peroxidation of arachidonic acid. We report that alpha,beta-unsaturated carbonyl compounds, e.g. the cyclopentenone prostaglandin, 15-deoxy-Delta 12,14-PGJ(2) (15d-PGJ(2)), and 4-hydroxy-2-nonenal (4HNE), alkylate (carbonylate), a subset of class I HDACs including HDAC1, -2, and -3, but not HDAC8. Covalent modification at two conserved cysteine residues, corresponding to Cys(261) and Cys(273) in HDAC1, coincided with attenuation of histone deacetylase activity, changes in histone H3 and H4 acetylation patterns, derepression of a LEF1 center dot beta-catenin model system, and transcription of HDAC-repressed genes, e. g. heme oxygenase-1 (HO-1), Gadd45, and HSP70. Identification of particular class I HDACs as components of the redox/electrophile-responsive proteome offers a basis for understanding how cells stratify their responses to varying degrees of pathophysiological oxidative stress associated with inflammation, cancer, and metabolic syndrome.
C1 [Doyle, Kelly; Fitzpatrick, F. A.] Univ Utah, Sch Pharm, Dept Med Chem, Salt Lake City, UT 84112 USA.
C3 Utah System of Higher Education; University of Utah
RP Fitzpatrick, FA (corresponding author), Kansas City Univ Med & Biosci, Dept Pharmacol & Microbiol, SEP 429,1750 Independence Ave, Kansas City, MO 64106 USA.
EM ffitzpatrick@kcumb.edu
FU National Institutes of Health [R01 AI 26730]; Dee Glen and Ida Smith
   Chair for Cancer Research
FX This work was supported, in whole or in part, by National Institutes of
   Health Grant R01 AI 26730 (to F. A. F.). This work was also supported by
   the Dee Glen and Ida Smith Chair for Cancer Research.
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NR 65
TC 126
Z9 142
U1 0
U2 9
PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3996 USA
EI 1083-351X
J9 J BIOL CHEM
JI J. Biol. Chem.
PD JUN 4
PY 2010
VL 285
IS 23
BP 17417
EP 17424
DI 10.1074/jbc.M109.089250
PG 8
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 602IT
UT WOS:000278133400019
PM 20385560
OA Green Published
DA 2025-06-11
ER

PT J
AU Wong, SBA
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   Ho, Roger
   Guillen-Burgos, Hernan F.
   Teopiz, Kayla M.
   Phan, Lee
   Rosenblat, Joshua D.
   Zhang, Melanie
   Mcintyre, Roger S.
TI Suicide risk in persons with polycystic ovarian syndrome: a systematic
   review
SO ANNALS OF GENERAL PSYCHIATRY
LA English
DT Review
DE Polycystic ovarian syndrome; Suicide; Depression; MDD; TRD; PCOS;
   Insulin resistance; Metabolic syndrome
ID MAJOR DEPRESSIVE DISORDER; INSULIN-RESISTANCE; PSYCHIATRIC-DISORDERS;
   BIPOLAR DISORDER; WOMEN; HOPELESSNESS; VALPROATE; LIFE
AB BackgroundPolycystic ovarian syndrome (PCOS) is a common and increasingly prevalent reproductive and metabolic endocrine disorder that is characterized by metabolic alterations, hyperandrogenism, menstrual irregularities as well as an increased risk of depression. Available evidence suggests PCOS may also be associated with disparate aspects of suicidality. Herein, we sought to determine the prevalence of suicidal ideation, suicidal behaviours and completed suicide in the PCOS population.MethodsWe systematically searched PubMed, Ovid and Scopus databases from inception to January 7, 2024. A manual search was conducted on Google Scholar. Two reviewers independently screened the retrieved studies against the eligibility criteria (S.W. and G.H.L.). Human studies investigating suicide outcomes in women of reproductive age with a confirmed diagnosis of PCOS were included.ResultsEleven studies meeting our eligibility criteria were included. Although results were mixed, available evidence suggests that persons with PCOS are at an increased risk of suicidal ideation, self-harm and suicide attempts and are also differentially affected by psychiatric comorbidities (e.g., depressive disorders). Notwithstanding, suicide risk was not fully accounted for by the presence of mental illness, which suggests that PCOS may also be contributory.ConclusionPCOS is associated with an increased risk of suicidal ideation and behaviour and associated psychiatric comorbidities. Persons with PCOS should be routinely evaluated for the presence of clinically significant suicidality. Whether increased suicidality in PCOS populations is a direct effect of the disease state and/or is largely moderated by psychiatric comorbidity is a future research vista.
C1 [Wong, Sabrina; Le, Gia Han; Lim, Poh Khuen; Teopiz, Kayla M.; Phan, Lee] Brain & Cognit Discovery Fdn, 77 Bloor St West,Suite 617, Toronto, ON M5S 1M2, Canada.
   [Wong, Sabrina; Le, Gia Han; Phan, Lee; Rosenblat, Joshua D.] Univ Hlth Network, Mood Disorder Psychopharmacol Unit, Toronto, ON, Canada.
   [Wong, Sabrina; Rosenblat, Joshua D.; Mcintyre, Roger S.] Univ Toronto, Dept Pharmacol & Toxicol, Toronto, ON, Canada.
   [Le, Gia Han; Teopiz, Kayla M.; Rosenblat, Joshua D.] Univ Toronto, Inst Med Sci, Toronto, ON, Canada.
   [Lo, Heidi Ka Ying; Mcintyre, Roger S.] Univ Hong Kong, Dept Psychiat, Hong Kong, Peoples R China.
   [Rosenblat, Joshua D.; Zhang, Melanie] Univ Toronto, Dept Psychiat, Toronto, ON, Canada.
   [Cao, Bing] Southwest Univ, Fac Psychol, Key Lab Cognit & Personal, Minist Educ, Chongqing 400715, Peoples R China.
   [Ho, Roger] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Psychol Med, Singapore, Singapore.
   [Ho, Roger] Natl Univ Singapore, Inst Hlth Innovat & Technol iHealthtech, Singapore, Singapore.
   [Ho, Roger] Hong Kong Univ Sci & Technol, Fac Sci, Div Life Sci LIFS, Hong Kong, Peoples R China.
   [Rhee, Taeho Greg] Yale Sch Med, Dept Psychiat, New Haven, CT USA.
   [Rhee, Taeho Greg] Univ Connecticut, Sch Med, Dept Publ Hlth Sci, Farmington, CT USA.
   [Guillen-Burgos, Hernan F.] Hosp Univ San Ignacio, Pontificia Univ Javeriana, Dept Psychiat & Mental Hlth, Bogota, Colombia.
   [Guillen-Burgos, Hernan F.; Teopiz, Kayla M.] Univ Simon Bolivar, Ctr Clin & Translat Res, Barranquilla, Colombia.
   [Guillen-Burgos, Hernan F.] Univ El Bosque, Ctr Clin & Translat Res, Bogota, Colombia.
C3 University of Toronto; University Health Network Toronto; University of
   Toronto; University of Toronto; University of Hong Kong; University of
   Toronto; Ministry of Education - China; Southwest University - China;
   National University of Singapore; National University of Singapore; Hong
   Kong University of Science & Technology; Yale University; University of
   Connecticut; Pontificia Universidad Javeriana; Hospital Universitario
   San Ignacio; Universidad El Bosque
RP Mcintyre, RS (corresponding author), Univ Toronto, Dept Pharmacol & Toxicol, Toronto, ON, Canada.; Mcintyre, RS (corresponding author), Univ Hong Kong, Dept Psychiat, Hong Kong, Peoples R China.
EM sabrinal.wong@mail.utoronto.ca; hanny.le@mail.utoronto.ca;
   lokaying@hku.hk; bingcao@swu.edu.cn; pohkhuen@outlook.com;
   taeho.rhee@yale.edu; rogercmho@ust.hk; hguillen@javeriana.edu.co;
   kayla.teopiz@alumni.utoronto.ca; lee.phan@mail.utoronto.ca;
   joshua.rosenblat@uhn.ca; mc.zhang@mail.utoronto.ca;
   roger.mcintyre@bcdf.org
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NR 45
TC 0
Z9 0
U1 0
U2 0
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1744-859X
J9 ANN GEN PSYCHIATR
JI Ann. Gen. Psychiatr.
PD JUN 2
PY 2025
VL 24
IS 1
AR 38
DI 10.1186/s12991-025-00574-w
PG 13
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 3HL2Z
UT WOS:001500431200001
PM 40457354
DA 2025-06-11
ER

PT J
AU Tuzcu, A
   Muslu, L
AF Tuzcu, Ayla
   Muslu, Leyla
TI Screening Results of Non-communicable Diseases in Adults and Elderly
   People Living in the Rural Area: A Cross-sectional Descriptive Study
SO ERCIYES MEDICAL JOURNAL
LA English
DT Article
DE Non-communicable diseases; risk factors; screening; rural area; Turkey
ID RISK-FACTORS; URBAN; CANCER
AB Objective: The aim of this study is to determine the prevalence, risk, and cancer screening results of the non-communicable diseases (NCDs) in the province of Antalya, Turkey.
   Materials and Methods: The sample in this cross-sectional descriptive study included 441 volunteers (universe 3841) aged >40 years living in four rural areas in Antalya. The questionnaire used in the study was divided into three parts: descriptive characteristics, Finnish Diabetes Risk Score (FINDRISK), depression risk questionnaire, and cancer screening sections.
   Results: In total, 91.6% of the participants were aged >= 45 years, and at least one in 50.3% had a chronic disease. According to FINDRISK, 23.8% were in high, and 7.9% were in a very high risk group, 34.5% were slightly overweight, 56.2% were obese, and 26.7% had metabolic syndrome (MS). In total, 22.2% of the individuals were at a risk of depression. In cancer screenings, 32.1% of the women underwent mammography in the past 2 years, 33.6% underwent breast self-examination, and 60.3% underwent cervical cancer screening in the last 5 years. It was determined that 17.2% of participants underwent immunochemical fecal occult blood test.
   Conclusion: It was observed that approximately one-third of the participants are under risk in term of hypertension and diabetes mellitus. Compared with previous studies, screening rates have increased in recent years, but they are not at the desired level. There is a need to promote encouraging practices for individuals living in rural areas aimed at prevention of NCDs, screening, and effective management of these diseases.
C1 [Tuzcu, Ayla; Muslu, Leyla] Akdeniz Univ, Dept Publ Hlth Nursing, Fac Nursing, TR-07058 Antalya, Turkey.
C3 Akdeniz University
RP Muslu, L (corresponding author), Akdeniz Univ, Dept Publ Hlth Nursing, Fac Nursing, TR-07058 Antalya, Turkey.
EM leylamuslu@akdeniz.edu.tr
RI MUSLU, Leyla/I-7973-2017; Tuzcu, Ayla/C-1045-2016
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NR 28
TC 0
Z9 0
U1 0
U2 6
PU ERCIYES UNIV SCH MEDICINE
PI KAYSERI
PA ERCIYES UNIV TIP FAK 38039 MELIKGAZI, KAYSERI, 00000, TURKEY
SN 2149-2247
EI 2149-2549
J9 ERCIYES MED J
JI Erciyes Med. J.
PD MAR
PY 2020
VL 42
IS 1
BP 98
EP 104
DI 10.14744/etd.2019.31889
PG 7
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA KQ1YG
UT WOS:000516725700019
OA gold
DA 2025-06-11
ER

PT J
AU Xie, ZH
   Huang, MS
   Xu, W
   Liu, FW
   Huang, DH
AF Xie, Zhihong
   Huang, Mingshan
   Xu, Wang
   Liu, Fuwei
   Huang, Donghua
TI USP18 Curbs the Progression of Metabolic Hypertension by Suppressing
   JAK/STAT Pathway
SO CARDIOVASCULAR TOXICOLOGY
LA English
DT Article; Early Access
DE USP18; Transcriptome sequencing; Metabolic hypertension; Proliferation;
   Oxidative stress; JAK/STAT pathway; Rat
ID UBP43
AB Hypertension is a pathological state of the metabolic syndrome that increases the risk of cardiovascular disease. Managing hypertension is challenging, and we aimed to identify the pathogenic factors and discern therapeutic targets for metabolic hypertension (MHR). An MHR rat model was established with the combined treatment of a high-sugar, high-fat diet and ethanol. Histopathological observations were performed using hematoxylin-eosin and Sirius Red staining. Transcriptome sequencing was performed to screen differentially expressed genes. The role of ubiquitin-specific protease 18 (USP18) in the proliferation, apoptosis, and oxidative stress of HUVECs was explored using Cell Counting Kit-8, flow cytometry, and enzyme-linked immunosorbent assays. Moreover, USP18 downstream signaling pathways in MHR were screened, and the effects of USP18 on these signaling pathways were investigated by western blotting. In the MHR model, total cholesterol and low-density lipoprotein levels increased, while high-density lipoprotein levels decreased. Moreover, high vessel thickness and percentage of collagen were noted along with increased malondialdehyde, decreased superoxide dismutase and catalase levels. The staining results showed that the MHR model exhibited an irregular aortic intima and disordered smooth muscle cells. There were 78 differentially expressed genes in the MHR model, and seven hub genes, including USP18, were identified. USP18 overexpression facilitated proliferation and reduced apoptosis and oxidative stress in HUVECs treated with Ang in vitro. In addition, the JAK/STAT pathway was identified as a USP18 downstream signaling pathway, and USP18 overexpression inhibited the expression of JAK/STAT pathway-related proteins. Conclusively, USP18 restrained MHR progression by promoting cell proliferation, reversing apoptosis and oxidative stress, and suppressing the JAK/STAT pathway.
C1 [Xie, Zhihong; Huang, Mingshan; Xu, Wang; Liu, Fuwei; Huang, Donghua] Ganzhou Peoples Hosp, Dept Cardiol, 16 Meiguan Dadao, Ganzhou 341000, Jiangxi, Peoples R China.
RP Xie, ZH (corresponding author), Ganzhou Peoples Hosp, Dept Cardiol, 16 Meiguan Dadao, Ganzhou 341000, Jiangxi, Peoples R China.
EM xzh8880@163.com
RI XIE, Zhihong/B-2968-2011; huang, mingshan/KHT-2868-2024; Liu,
   Fuwei/JQM-5783-2023
OI Huang, Mingshan/0009-0006-4658-9000
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NR 46
TC 2
Z9 2
U1 1
U2 4
PU HUMANA PRESS INC
PI TOTOWA
PA 999 RIVERVIEW DRIVE SUITE 208, TOTOWA, NJ 07512 USA
SN 1530-7905
EI 1559-0259
J9 CARDIOVASC TOXICOL
JI Cardiovasc. Toxicol.
PD 2024 APR 30
PY 2024
DI 10.1007/s12012-024-09860-7
EA APR 2024
PG 11
WC Cardiac & Cardiovascular Systems; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Toxicology
GA RX8C9
UT WOS:001231038800002
PM 38691302
DA 2025-06-11
ER

PT J
AU Liu, WS
   Baker, SS
   Baker, RD
   Zhu, LX
AF Liu, Wensheng
   Baker, Susan S.
   Baker, Robert D.
   Zhu, Lixin
TI Antioxidant Mechanisms in Nonalcoholic Fatty Liver Disease
SO CURRENT DRUG TARGETS
LA English
DT Article
DE Antioxidant; alcohol metabolism; fatty acid oxidation; lipid metabolism;
   NAFLD; NASH; oxidative stress; reactive oxygen species
ID MANGANESE SUPEROXIDE-DISMUTASE; OXIDATIVE DNA-DAMAGE; HEPATIC
   CYTOCHROME-P450 2E1; ALVEOLAR EPITHELIAL-CELLS; STRESS-RELATED
   PARAMETERS; SERUM THIOREDOXIN LEVELS; LIPID-PEROXIDATION; MITOCHONDRIAL
   DYSFUNCTION; INSULIN-RESISTANCE; GENE-EXPRESSION
AB Nonalcoholic fatty liver disease (NAFLD) represents a broad spectrum of histological abnormalities with clinical presentations ranging from hepatic steatosis to nonalcoholic steatohepatitis (NASH). Some NAFLD patients may progress to cirrhosis and ultimately hepatocellular carcinoma (HCC). Hepatic steatosis, the hallmark of NAFLD, is defined by the accumulation of triglycerides (TGs) in more than 5% of the hepatocytes. NASH is characterized by inflammation along with variable degrees of fibrosis in addition to steatosis. NAFLD has been considered to be the hepatic manifestation of metabolic syndrome (MS), as it is frequently associated with MS conditions such as insulin resistance (IR) and obesity. Hepatic steatosis mainly results from disrupted homeostasis of lipid metabolism in the setting of IR. Although the mechanism underlying the progression from steatosis to NASH is still not fully elucidated, mounting evidence has suggested oxidative stress (OS) to be a key driving force. Elevated OS has been well documented in NAFLD patients. OS can cause direct damages to lipid, protein, and DNA molecules and trigger the inflammatory and fibrogenesis signaling pathways, which promotes the progression from steatosis to NASH. OS may also have various effects on antioxidant defense mechanisms. Overproduced reactive oxygen species (ROS) may directly deplete antioxidant molecules such as glutathione (GSH) and inhibit the activities of antioxidant enzymes such as superoxide dismutase (SOD). ROS may also induce the expression of antioxidant genes to counteract the OS effects. The aim of this review is to discuss oxidative stress and antioxidant mechanisms in NAFLD.
C1 [Liu, Wensheng; Baker, Susan S.; Baker, Robert D.; Zhu, Lixin] SUNY Buffalo, Digest Dis & Nutr Ctr, Dept Pediat, Buffalo, NY 14214 USA.
   [Zhu, Lixin] Shanghai Univ Tradit Chinese Med, Longhua Hosp, Inst Digest Dis, Shanghai, Peoples R China.
C3 State University of New York (SUNY) System; University at Buffalo, SUNY;
   Shanghai University of Traditional Chinese Medicine
RP Liu, WS (corresponding author), SUNY Buffalo, Digest Dis & Nutr Ctr, Dept Pediat, 3435 Main St,422BRB, Buffalo, NY 14214 USA.
EM wl11@buffalo.eduand; lixinzhu@buffalo.edu
RI Zhu, Lixin/ACE-1496-2022
OI Zhu, Lixin/0000-0001-7904-1769
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   EMIRATES
SN 1389-4501
EI 1873-5592
J9 CURR DRUG TARGETS
JI Curr. Drug Targets
PY 2015
VL 16
IS 12
BP 1301
EP 1314
DI 10.2174/1389450116666150427155342
PG 14
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA CT5MY
UT WOS:000362855700005
PM 25915484
DA 2025-06-11
ER

PT J
AU Lopes, A
   Vilela, TC
   Taschetto, L
   Vuolo, F
   Petronilho, F
   Dal-Pizzol, F
   Streck, EL
   Ferreira, GC
   Schuck, PF
AF Lopes, Abigail
   Vilela, Thais Cereser
   Taschetto, Luciane
   Vuolo, Franciele
   Petronilho, Fabricia
   Dal-Pizzol, Felipe
   Streck, Emilio Luiz
   Ferreira, Gustavo Costa
   Schuck, Patricia Fernanda
TI Evaluation of the Effects of Fructose on Oxidative Stress and
   Inflammatory Parameters in Rat Brain
SO MOLECULAR NEUROBIOLOGY
LA English
DT Article
DE Brain; Fructosemia; Oxidative damage; Neuroinflammation; Hereditary
   fructose intolerance
ID INSULIN-RESISTANCE; METABOLIC SYNDROME; SPECTROPHOTOMETRIC METHOD;
   INDUCED HYPERURICEMIA; HEPATIC STEATOSIS; INBORN-ERRORS; INTOLERANCE;
   ACID; MICE; DIET
AB Hereditary fructose intolerance is an autosomal recessive disorder characterized by the accumulation of fructose in tissues and biological fluids of patients. The disease results from a deficiency of aldolase B, responsible for metabolizing fructose in the liver, kidney, and small intestine. We investigated the effect of acute fructose administration on oxidative stress and neuroinflammatory parameters in the cerebral cortex of 30-day-old Wistar rats. Animals received subcutaneous injection of sodium chloride (0.9 %) (control group) or fructose solution (5 mu mol/g) (fructose group). One hour later, the animals were euthanized and the cerebral cortex was isolated. Oxidative stress (levels of thiobarbituric acid-reactive substances (TBA-RS), carbonyl content, nitrate and nitrite levels, 2',7'-dihydrodichlorofluorescein (DCFH) oxidation, glutathione (GSH) levels, as well as the activities of catalase (CAT) and superoxide dismutase (SOD)) and neuroinflammatory parameters (TNF-alpha, IL-1 beta, and IL-6 levels and myeloperoxidase (MPO) activity) were investigated. Acute fructose administration increased levels of TBA-RS and carbonyl content, indicating lipid peroxidation and protein damage. Furthermore, SOD activity increased, whereas CATactivity was decreased. The levels of GSH, nitrate, and nitrite and DCFH oxidation were not altered by acute fructose administration. Finally, cytokines IL-1 beta, IL-6, and TNF-alpha levels, as well as MPO activity, were not altered. Our present data indicate that fructose provokes oxidative stress in the cerebral cortex, which induces oxidation of lipids and proteins and changes of CAT and SOD activities. It seems therefore reasonable to propose that antioxidants may serve as an adjuvant therapy to diets or to other pharmacological agents used for these patients, to avoid oxidative damage to the brain.
C1 [Lopes, Abigail; Vilela, Thais Cereser; Taschetto, Luciane; Schuck, Patricia Fernanda] Univ Extremo Sul Catarinense, Lab Erros Inatos Metab, Programa Posgrad Ciencias Saude, Unidade Acad Ciencias Saude, BR-88806000 Criciuma, SC, Brazil.
   [Vuolo, Franciele; Dal-Pizzol, Felipe] Univ Extremo Sul Catarinense, Lab Fisiopatol Expt, Programa Posgrad Ciencias Saude, Unidade Acad Ciencias Saude, BR-88806000 Criciuma, SC, Brazil.
   [Petronilho, Fabricia] Univ Sul Santa Catarina, Lab Fisiopatol Clin & Expt, Programa Posgrad Ciencias Saude, Tubarao, SC, Brazil.
   [Streck, Emilio Luiz] Univ Extremo Sul Catarinense, Lab Bioenerget, Programa Posgrad Ciencias Saude, Unidade Acad Ciencias Saude, BR-88806000 Criciuma, SC, Brazil.
   [Ferreira, Gustavo Costa] Univ Fed Rio de Janeiro, Inst Biofis Carlos Chagas Filho, BR-21941902 Rio De Janeiro, RJ, Brazil.
C3 Universidade do Extremo Sul Catarinense; Universidade do Extremo Sul
   Catarinense; Universidade do Sul de Santa Catarina; Universidade do
   Extremo Sul Catarinense; Universidade Federal do Rio de Janeiro
RP Schuck, PF (corresponding author), Univ Extremo Sul Catarinense, Lab Erros Inatos Metab, Programa Posgrad Ciencias Saude, Unidade Acad Ciencias Saude, Ave Univ 1105,Bloco S,Sala 6, BR-88806000 Criciuma, SC, Brazil.
EM patischuck@gmail.com
RI Ferreira, Carlos/G-4957-2013; Petronilho, Fabricia/D-8822-2013; Streck,
   Emilio/J-7558-2013; da Costa Ferreira, Gustavo/B-6983-2014; Dal Pizzol,
   Felipe/F-2756-2015; Schuck, Patricia Fernanda/O-1344-2013
OI da Costa Ferreira, Gustavo/0000-0002-2892-8842; Dal Pizzol,
   Felipe/0000-0003-3003-8977; , luciane/0000-0002-0889-629X; Petronilho,
   Fabricia/0000-0003-3240-2808; Vilela, Thais Cereser/0000-0002-2986-1715;
   Schuck, Patricia Fernanda/0000-0003-3148-4952
FU Conselho Nacional de Pesquisa e Desenvolvimento (CNPq); Universidade do
   Extremo Sul Catarinense (UNESC); Nucleo de Excelencia em Neurociencias
   Aplicadas de Santa Catarina (NENASC project); Nucleo de Excelencia em
   Neurociencias Aplicadas de Santa Catarina (PRONEX)
FX This study was supported by grants from Conselho Nacional de Pesquisa e
   Desenvolvimento (CNPq), Universidade do Extremo Sul Catarinense (UNESC),
   and Nucleo de Excelencia em Neurociencias Aplicadas de Santa Catarina
   (NENASC project, PRONEX). We thank Soliany Grassi Maravai for the
   determination of fructose levels in the serum of the animals.
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NR 62
TC 23
Z9 24
U1 1
U2 24
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0893-7648
EI 1559-1182
J9 MOL NEUROBIOL
JI Mol. Neurobiol.
PD DEC
PY 2014
VL 50
IS 3
BP 1124
EP 1130
DI 10.1007/s12035-014-8676-y
PG 7
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA AT3WU
UT WOS:000344865700031
PM 24691544
DA 2025-06-11
ER

PT J
AU Lugogo, NL
   Bappanad, D
   Kraft, M
AF Lugogo, Njira L.
   Bappanad, Divya
   Kraft, Monica
TI Obesity, metabolic dysregulation and oxidative stress in asthma
SO BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
LA English
DT Review
DE Asthma; Obesity; Metabolic syndrome; Oxidative stress; Leptin;
   Inflammation
ID BODY-MASS INDEX; EXHALED NITRIC-OXIDE; HUMAN ADIPOSE-TISSUE;
   WEIGHT-LOSS; AIRWAY INFLAMMATION; ADIPONECTIN EXPRESSION;
   INSULIN-RESISTANCE; SERUM ADIPONECTIN; LUNG-FUNCTION; VISCERAL FAT
AB Background: Epidemiological data demonstrate an increased risk of developing incident asthma with increasing adiposity. While the vast majority of studies support the interaction between obesity and asthma, the causality is unclear.
   Scope of review: This article will review the current literature supporting the presence of an obese asthma phenotype and the possible mechanisms mediating the effects of obesity on asthma.
   Major conclusions: Obesity is associated with poor asthma control, altered responsiveness to medications and increased morbidity. Obesity is characterized by systemic inflammation that may result in increased airway inflammation. However, this assertion is not supported by current studies that demonstrate a lack of significant airway inflammation in obese asthmatics. In spite this observation one must consider limitations of these studies including the fact that most subjects were treated with inhaled corticosteroids that would likely alter inflammation in the lung. Thus, it remains unclear if obesity is associated with alterations in inflammation in the airways of subjects with asthma.
   Hormones such as leptin and adiponectin are affected by obesity and may play a role in mediating innate immune responses and allergic responses, respectively. The role of oxidative stress remains controversial and the current evidence suggests that while oxidative stress is important in asthma, it does not fully explain the characteristics associated with this unique phenotype.
   General significance: Obesity related asthma is associated with increased morbidity and differential response to asthma therapies. Understanding the mechanisms mediating this phenotype would have significant implications for millions of people suffering with asthma. This article is part of a Special Issue entitled Biochemistry of Asthma. (C) 2011 Published by Elsevier B.V.
C1 [Lugogo, Njira L.] Duke Univ, Med Ctr, Dept Med, Durham, NC 27710 USA.
C3 Duke University
RP Lugogo, NL (corresponding author), Duke Univ, Med Ctr, Dept Med, POB 2629, Durham, NC 27710 USA.
EM njira.lugogo@duke.edu
OI Lugogo, Njira/0000-0002-0235-7105
FU NCRR NIH HHS [M01 RR000051] Funding Source: Medline; NHLBI NIH HHS [P50
   HL084917, P01 HL073907, P01 HL108793, R01 HL064619] Funding Source:
   Medline; NIAID NIH HHS [P01 AI081672] Funding Source: Medline
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NR 93
TC 46
Z9 49
U1 0
U2 18
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0304-4165
EI 1872-8006
J9 BBA-GEN SUBJECTS
JI Biochim. Biophys. Acta-Gen. Subj.
PD NOV
PY 2011
VL 1810
IS 11
SI SI
BP 1120
EP 1126
DI 10.1016/j.bbagen.2011.09.004
PG 7
WC Biochemistry & Molecular Biology; Biophysics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics
GA 847BD
UT WOS:000296946000016
PM 21944975
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Shabsigh, R
   Kaufman, J
   Magee, M
   Creanga, D
   Russell, D
   Budhwani, M
AF Shabsigh, Ridwan
   Kaufman, Joel
   Magee, Michelle
   Creanga, Dana
   Russell, David
   Budhwani, Meeta
TI Lack of awareness of erectile dysfunction in many men with risk factors
   for erectile dysfunction
SO BMC UROLOGY
LA English
DT Article
ID QUALITY-OF-LIFE; INTERNATIONAL INDEX; TREATMENT-SEEKING; SATISFACTION;
   HYPERTENSION; DEPRESSION; PREVALENCE
AB Background: Men with erectile dysfunction often have concurrent medical conditions. Conversely, men with these conditions may also have underlying erectile dysfunction. The prevalence of unrecognized erectile dysfunction in men with comorbidities commonly associated with erectile dysfunction was determined in men invited to participate in a double-blind, randomized, placebo-controlled trial of sildenafil citrate.
   Methods: Men >= 30 years old presenting with >= 1 erectile dysfunction risk factor (controlled hypertension, hypercholesterolemia, smoking, metabolic syndrome, stable coronary artery disease, diabetes, depression, lower urinary tract symptoms, obesity [body mass index >= 30 kg/m(2)] or waist circumference >= 40 inches), and not previously diagnosed with erectile dysfunction were evaluated. The screening question, "Do you have erectile dysfunction?," with responses of " no," " yes," and " unsure," and the Erectile Function domain of the International Index of Erectile Function (IIEF-EF) were administered.
   Results: Of 1084 men screened, 1053 answered the screening question and also had IIEF-EF scores. IIEF-EF scores indicating erectile dysfunction occurred in 71% (744/1053), of whom 54% (399/744) had moderate or severe erectile dysfunction. Of 139 answering " yes," 526 answering " unsure," and 388 answering " no," 96%, 90%, and 36%, respectively, had some degree of erectile dysfunction. The mean +/- SD (range) number of risk factors was 2.9 +/- 1.7 (3-8) in the "yes" group, 3.2 +/- 1.7 (3-9) in the "unsure" group, and 2.6 +/- 1.5 (2-8) in the "no" group.
   Conclusion: Although awareness of having erectile dysfunction was low, most men with risk factors had IIEF-EF scores indicating erectile dysfunction. Erectile dysfunction should be suspected and assessed in men with risk factors, regardless of their apparent level of awareness of erectile dysfunction.
C1 [Shabsigh, Ridwan] Maimonides Hosp, Brooklyn, NY 11219 USA.
   [Shabsigh, Ridwan] Columbia Univ, New York, NY USA.
   [Kaufman, Joel] Urol Res Opt, Aurora, CO USA.
   [Magee, Michelle] MedStar Res Inst, Washington, DC USA.
   [Creanga, Dana; Russell, David; Budhwani, Meeta] Pfizer Inc, New York, NY USA.
C3 Maimonides Medical Center; Columbia University; Pfizer; Pfizer USA
RP Russell, D (corresponding author), Pfizer Inc, New York, NY USA.
EM david.russell01@pfizer.com
RI Russell, David/IXN-3147-2023
FU Pfizer Inc.; Sanofi-Aventis; Johnson & Johnson NovoNordisk; Bayer;
   Lilly; Pfizer
FX This study was funded by Pfizer Inc. Dana Creanga was a paid consultant
   to Pfizer in connection with the development of this manuscript.
   Employees of the sponsor participated in the design of the study;
   collection, analysis and interpretation of the data; writing of the
   manuscript; and in the decision to submit the manuscript for
   publication. Editorial support was provided by Janet E. Matsuura, PhD,
   of Complete Healthcare Communications, Inc., and was funded by Pfizer
   Inc.Ridwan Shabsigh, MD, has been a consultant or advisor for Pfizer,
   Eli Lilly, Endo Pharmaceuticals, Boehringer Ingelheim, Bayer Schering
   Pharma, Dong-A Pharmtech and American Medical Systems and an
   investigator for Auxilium, Vivus and BioSante. Joel Kaufman, MD, has
   been a consultant or advisor for Indevus and Eli Lilly; a meeting
   participant or lecturer for Pfizer Inc and Coloplast; a speakers' bureau
   member for Novartis and Astellas; and a scientific study/trial
   investigator for Pfizer, Eli Lilly, Amgen, Solvay, Indevus, and GTX.
   Michelle Magee, MD, is a consultant for Sanofi-Aventis, a speaker for
   Sanofi-Aventis, NovoNordisk, Tethys BioScience, and Merck and receives
   support for investigator-initiated clinical trials from Sanofi-Aventis.
   She has also received funding for community outreach programs from
   Johnson & Johnson NovoNordisk, Bayer, Lilly, Pfizer, and Sanofi-Aventis.
   Dana Creanga was a paid consultant to Pfizer in connection with the
   development of this manuscript. David Russell and Meeta Budhwani are
   employees of Pfizer Inc. The study was funded by Pfizer Inc
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NR 25
TC 26
Z9 30
U1 0
U2 14
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1471-2490
J9 BMC UROL
JI BMC Urol.
PY 2010
VL 10
AR 18
DI 10.1186/1471-2490-10-18
PG 7
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA V27CW
UT WOS:000208592300018
PM 21054874
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Grigolon, RB
   Trevizol, AP
   Cerqueira, RO
   Lee, Y
   Mansur, RB
   McIntyre, RS
   Brietzke, E
AF Grigolon, Ruth B.
   Trevizol, Alisson P.
   Cerqueira, Raphael O.
   Lee, Yena
   Mansur, Rodrigo B.
   McIntyre, Roger S.
   Brietzke, Elisa
TI Hypersomnia and Bipolar Disorder: A systematic review and meta-analysis
   of proportion
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Review
DE Bipolar Disorder; Depression; Chronobiology; Circadian rhythm;
   Hypersomnia
ID OBSTRUCTIVE SLEEP-APNEA; QUALITY-OF-LIFE; UNIPOLAR DEPRESSION; METABOLIC
   SYNDROME; ATYPICAL FEATURES; SYMPTOMS; MARKERS; DISTURBANCE; STIMULANTS;
   PARAMETERS
AB Background: Hypersomnia is a common problem amongst individuals with Bipolar Disorder (BD). The objective of this meta-analysis is to estimate the frequency of hypersomnia in individuals with BD, and identify associated factors
   Methods: Our search focused on articles documenting the frequency of hypersomnia among individuals with BD indexed in PubMed database and in the Cochrane Library, following the recommendations from the Meta-Analysis Of Observational Studies in Epidemiology (MOOSE) Group. A meta-analysis of proportion was conducted; funnel plot and Egger's test were used for the assessment of publication bias. Subgroups analyses were performed in order to evaluate possible confounders and associated factors.
   Results: We identified 10 studies, which included 1824 patients with BD. The overall estimate of the proportion of BD cases that reported hypersomnia was 29.9% [95% confidence interval (CI): 25.8-34.1%, I-2=59.2%; p<.05]. The funnel plot and the Egger's test suggest a low risk of publication bias (p=.527). The polarity of mood state, Bipolar Disorder type, use of medication, age, diagnostic criteria and hypersomnia criteria were not significantly related to hypersomnia.
   Limitations: There is a possibility that smaller cross-sectional studies were not included. The high heterogeneity between studies is frequent in meta-analysis of both interventional and observational studies. Hypersomnia was not the primary outcome in some of the included studies.
   Conclusions: To our knowledge, this is the first systematic review and meta-analysis of hypersomnia prevalence in patients with BD. Further studies focused on clinical correlates and implications for health outcomes in BD are warranted.
C1 [Grigolon, Ruth B.; Cerqueira, Raphael O.; Brietzke, Elisa] Univ Fed Sao Paulo, Dept Psychiat, Sao Paulo, SP, Brazil.
   [Trevizol, Alisson P.] Univ Toronto, Dept Psychiat, Toronto, ON, Canada.
   [Trevizol, Alisson P.] Temerty Ctr Therapeut Brain Intervent, Toronto, ON, Canada.
   [Trevizol, Alisson P.] Ctr Addict & Mental Hlth, Campbell Family Res Inst, 1001 Queen St W Unit 4,Room 179, Toronto, ON M6J 1H4, Canada.
   [McIntyre, Roger S.] Brain & Cognit Discovery Fdn, Toronto, ON, Canada.
   [Lee, Yena; Mansur, Rodrigo B.; McIntyre, Roger S.; Brietzke, Elisa] Univ Hlth Network, Mood Disorders Psychopharmacol Unit, Toronto, ON, Canada.
C3 Universidade Federal de Sao Paulo (UNIFESP); University of Toronto;
   University of Toronto; Centre for Addiction & Mental Health - Canada;
   University of Toronto; University Health Network Toronto
RP Trevizol, AP (corresponding author), Ctr Addict & Mental Hlth, Campbell Family Res Inst, 1001 Queen St W Unit 4,Room 179, Toronto, ON M6J 1H4, Canada.; Trevizol, AP (corresponding author), Univ Toronto, Temerty Ctr Therapeut Brain Intervent, Dept Psychiat, 1001 Queen St W Unit 4,Room 179, Toronto, ON M6J 1H4, Canada.
EM alisson.trevizol@camh.ca
RI McIntyre, Roger/AAU-1000-2020; Lee, Yena/L-5505-2019; Grigolon,
   Ruth/AAG-3935-2019; Brietzke, Elisa/G-9559-2012; Trevizol,
   Alisson/W-3160-2018; Mansur, Rodrigo/N-7131-2019; Trevizol,
   Alisson/C-4679-2017
OI Cerqueira, Raphael/0000-0002-9219-2534; Lee, Yena/0000-0003-0629-9456;
   Trevizol, Alisson/0000-0002-6065-9355; Grigolon,
   Ruth/0000-0003-0038-9530
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NR 49
TC 14
Z9 16
U1 0
U2 7
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD MAR 1
PY 2019
VL 246
BP 659
EP 666
DI 10.1016/j.jad.2018.12.030
PG 8
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA HJ6EE
UT WOS:000457276200080
PM 30611064
DA 2025-06-11
ER

PT J
AU Sorop, O
   Heinonen, I
   van Kranenburg, M
   van de Wouw, J
   de Beer, VJ
   Nguyen, ITN
   Octavia, Y
   van Duin, RWB
   Stam, K
   van Geuns, RJ
   Wielopolski, PA
   Krestin, GP
   van den Meiracker, AH
   Verjans, R
   van Bilsen, M
   Danser, AHJ
   Paulus, WJ
   Cheng, C
   Linke, WA
   Joles, JA
   Verhaar, MC
   van der Velden, J
   Merkus, D
   Duncker, DJ
AF Sorop, Oana
   Heinonen, Ilkka
   van Kranenburg, Matthijs
   van de Wouw, Jens
   de Beer, Vincent J.
   Nguyen, Isabel T. N.
   Octavia, Yanti
   van Duin, Richard W. B.
   Stam, Kelly
   van Geuns, Robert-Jan
   Wielopolski, Piotr A.
   Krestin, Gabriel P.
   van den Meiracker, Anton H.
   Verjans, Robin
   van Bilsen, Marc
   Danser, A. H. Jan
   Paulus, Walter J.
   Cheng, Caroline
   Linke, Wolfgang A.
   Joles, Jaap A.
   Verhaar, Marianne C.
   van der Velden, Jolanda
   Merkus, Daphne
   Duncker, Dirk J.
TI Multiple common comorbidities produce left ventricular diastolic
   dysfunction associated with coronary microvascular dysfunction,
   oxidative stress, and myocardial stiffening
SO CARDIOVASCULAR RESEARCH
LA English
DT Article
DE Translational studies; Coronary circulation; Oxidant stress;
   Endothelium/nitric oxide; Heart failure
ID PRESERVED EJECTION FRACTION; HEART-FAILURE; NONCARDIAC COMORBIDITIES;
   METABOLIC SYNDROME; PRESSURE-OVERLOAD; MODEL; INFLAMMATION; MECHANISMS;
   POPULATION; STIFFNESS
AB Aims More than 50% of patients with heart failure have preserved ejection fraction characterized by diastolic dysfunction. The prevalance of diastolic dysfunction is higher in females and associates with multiple comorbidities such as hypertension (HT), obesity, hypercholesterolemia (HC), and diabetes mellitus (DM). Although its pathophysiology remains incompletely understood, it has been proposed that these comorbidities induce systemic inflammation, coronary microvascular dysfunction, and oxidative stress, leading to myocardial fibrosis, myocyte stiffening and, ultimately, diastolic dysfunction. Here, we tested this hypothesis in a swine model chronically exposed to three common comorbidities.
   Methods and results DM (induced by streptozotocin), HC (produced by high fat diet), and HT (resulting from renal artery embolization), were produced in 10 female swine, which were followed for 6 months. Eight female healthy swine on normal pig-chow served as controls. The DM+HC+HT group showed hyperglycemia, HC, hypertriglyceridemia, renal dysfunction and HT, which were associated with systemic inflammation. Myocardial superoxide production was markedly increased, due to increased NOX activity and eNOS uncoupling, and associated with reduced NO production, and impaired coronary small artery endothelium-dependent vasodilation. These abnormalities were accompanied by increased myocardial collagen content, reduced capillary/fiber ratio, and elevated passive cardiomyocyte stiffness, resulting in an increased left ventricular end-diastolic stiffness (measured by pressure-volume catheter) and a trend towards a reduced E/A ratio (measured by cardiac MRI), while ejection fraction was maintained.
   Conclusions The combination of three common comorbidities leads to systemic inflammation, myocardial oxidative stress, and coronary microvascular dysfunction, which associate with myocardial stiffening and LV diastolic dysfunction with preserved ejection fraction.
C1 [Sorop, Oana; Heinonen, Ilkka; van Kranenburg, Matthijs; van de Wouw, Jens; de Beer, Vincent J.; Octavia, Yanti; van Duin, Richard W. B.; Stam, Kelly; van Geuns, Robert-Jan; Cheng, Caroline; Merkus, Daphne; Duncker, Dirk J.] Erasmus Univ, Med Ctr, Thoraxctr,Cardiovasc Res Sch COEUR, Div Expt Cardiol,Dept Cardiol, Rotterdam, Netherlands.
   [Heinonen, Ilkka] Univ Turku, Turku PET Ctr, Turku, Finland.
   [Heinonen, Ilkka] Turku Univ Hosp, Turku, Finland.
   [van Kranenburg, Matthijs; van Geuns, Robert-Jan; Wielopolski, Piotr A.; Krestin, Gabriel P.] Erasmus Univ, Med Ctr, Cardiovasc Res Sch COEUR, Dept Radiol, Rotterdam, Netherlands.
   [Nguyen, Isabel T. N.; Cheng, Caroline; Joles, Jaap A.; Verhaar, Marianne C.] Univ Med Ctr Utrecht, Dept Hypertens & Nephrol, Utrecht, Netherlands.
   [van den Meiracker, Anton H.; Danser, A. H. Jan] Erasmus Univ, Cardiovasc Res Sch COEUR, Med Ctr, Dept Internal Med, Rotterdam, Netherlands.
   [Verjans, Robin; van Bilsen, Marc] Maastricht Univ, Dept Cardiol, Maastricht, Netherlands.
   [van Bilsen, Marc] Maastricht Univ, Cardiovasc Res Inst Maastricht CARIM, Dept Physiol, Maastricht, Netherlands.
   [Paulus, Walter J.; van der Velden, Jolanda] VU Univ Med Ctr Amsterdam, ACS, Dept Physiol, Amsterdam, Netherlands.
   [Linke, Wolfgang A.] Univ Munster, Inst Physiol 2, Munster, Germany.
   [van der Velden, Jolanda; Duncker, Dirk J.] Netherlands Heart Inst, Utrecht, Netherlands.
C3 Erasmus University Rotterdam; Erasmus MC; University of Turku;
   University of Turku; Erasmus University Rotterdam; Erasmus MC; Utrecht
   University; Utrecht University Medical Center; Erasmus University
   Rotterdam; Erasmus MC; Maastricht University; Maastricht University;
   Vrije Universiteit Amsterdam; VU UNIVERSITY MEDICAL CENTER; University
   of Munster
RP Duncker, DJ (corresponding author), Erasmus Univ, Med Ctr, Thoraxctr,Cardiovasc Res Sch COEUR, Div Expt Cardiol,Dept Cardiol, Rotterdam, Netherlands.; Duncker, DJ (corresponding author), Netherlands Heart Inst, Utrecht, Netherlands.
EM d.duncker@erasmusmc.nl
RI van den Born, Bert-Jan/IUQ-0970-2023; Verhaar, Marianne/AAM-6788-2020;
   de Beer, Vincent/A-9068-2012; van der Velden, J/D-1925-2016; Danser,
   Jan/GLR-1479-2022; Joles, Jaap/AAX-3249-2020; Merkus,
   Daphne/AAN-4459-2020; Bilsen, Marc/E-8342-2016; van Geuns,
   Robert-Jan/N-7976-2017; Linke, Wolfgang/IXD-9988-2023
OI van de Wouw, Jens/0000-0001-7133-3046; de Beer,
   Vincent/0000-0002-1447-9732; Linke, Wolfgang/0000-0003-0801-3773;
   Verjans, Robin/0000-0001-5911-8917; van Duin,
   Richard/0000-0003-4037-726X; van der Velden,
   Jolanda/0000-0001-5224-5788; Verhaar, Marianne/0000-0002-3276-6428
FU European Commission FP7-Health-2010 grant [MEDIA-261409]; Netherlands
   CardioVascular Research Initiative: an initiative of the Dutch Heart
   Foundation [CVON2011-11, CVON2012-08, CVON2014-11]; Academy of Finland
   [251272]; Finnish Diabetes Research Foundation; Finnish Foundation for
   Cardiovascular Research
FX This study was supported by grants from the European Commission
   FP7-Health-2010 grant MEDIA-261409, the Netherlands CardioVascular
   Research Initiative: an initiative with support of the Dutch Heart
   Foundation [CVON2011-11 (ARENA), CVON2012-08 (PHAEDRA), CVON2014-11
   (RECONNECT)] and The Academy of Finland 251272, Finnish Diabetes
   Research Foundation, and Finnish Foundation for Cardiovascular Research.
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NR 45
TC 154
Z9 159
U1 2
U2 25
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0008-6363
EI 1755-3245
J9 CARDIOVASC RES
JI Cardiovasc. Res.
PD JUN 1
PY 2018
VL 114
IS 7
BP 954
EP 964
DI 10.1093/cvr/cvy038
PG 11
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA GI1HT
UT WOS:000434122000011
PM 29432575
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Pardo, V
   González-Rodríguez, A
   Guijas, C
   Balsinde, J
   Valverde, AM
AF Pardo, Virginia
   Gonzalez-Rodriguez, Agueda
   Guijas, Carlos
   Balsinde, Jesus
   Valverde, Angela M.
TI Opposite Cross-Talk by Oleate and Palmitate on Insulin Signaling in
   Hepatocytes through Macrophage Activation
SO JOURNAL OF BIOLOGICAL CHEMISTRY
LA English
DT Article
ID TYROSINE-PHOSPHATASE 1B; NECROSIS-FACTOR-ALPHA; ENDOPLASMIC-RETICULUM
   STRESS; SATURATED FATTY-ACIDS; NF-KAPPA-B; ADIPOSE-TISSUE; INDUCED
   INFLAMMATION; GLUCOSE-HOMEOSTASIS; METABOLIC SYNDROME; LIPID HOMEOSTASIS
AB Chronic low grade inflammation in adipose tissue during obesity is associated with an impairment of the insulin signaling cascade. In this study, we have evaluated the impact of palmitate or oleate overload of macrophage/Kupffer cells in triggering stress-mediated signaling pathways, in lipoapoptosis, and in the cross-talk with insulin signaling in hepatocytes. RAW 264.7 macrophages or Kupffer cells were stimulated with oleate or palmitate, and levels of M1/M2 polarization markers and the lipidomic profile of eicosanoids were analyzed. Whereas proinflammatory cytokines and total eicosanoids were elevated in macrophages/Kupffer cells stimulated with palmitate, enhanced arginase 1 and lower leukotriene B-4 (LTB4) levels were detected in macrophages stimulated with oleate. When hepatocytes were pretreated with conditioned medium (CM) from RAW 264.7 or Kupffer cells loaded with palmitate (CM-P), phosphorylation of stress kinases and endoplasmic reticulum stress signaling was increased, insulin signaling was impaired, and lipoapoptosis was detected. Conversely, enhanced insulin receptor-mediated signaling and reduced levels of the phosphatases protein tyrosine phosphatase 1B (PTP1B) and phosphatase and tensin homolog (PTEN) were found in hepatocytes treated with CM from macrophages stimulated with oleate (CM-O). Supplementation ofCM-OwithLTB(4) suppressed insulin sensitization and increased PTP1B and PTEN. Furthermore, LTB4 decreased insulin receptor tyrosine phosphorylation in hepatocytes, activated the NF kappa B pathway, and up-regulated PTP1B and PTEN, these effects being mediated by LTB4 receptor BTL1. In conclusion, oleate and palmitate elicit an opposite cross-talk between macrophages/Kupffer cells and hepatocytes. Whereas CM-P interferes at the early steps of insulin signaling, CM-O increases insulin sensitization, possibly by reducing LTB4.
C1 [Pardo, Virginia; Gonzalez-Rodriguez, Agueda] Univ Autonoma Madrid, Consejo Super Invest Cient, Inst Invest Biomed Alberto Sols, Madrid 28029, Spain.
   [Pardo, Virginia; Gonzalez-Rodriguez, Agueda; Guijas, Carlos; Balsinde, Jesus; Valverde, Angela M.] Inst Salud Carlos III, Ctr Invest Biomed Red Diabet & Enfermedades Metab, Madrid 28029, Spain.
   [Guijas, Carlos; Balsinde, Jesus; Valverde, Angela M.] CSIC, Inst Biol & Genet Mol, Valladolid 47003, Spain.
C3 Autonomous University of Madrid; Consejo Superior de Investigaciones
   Cientificas (CSIC); CSIC - Instituto de Investigaciones Biomedicas
   Alberto Sols (IIBM); Instituto de Salud Carlos III; CIBER - Centro de
   Investigacion Biomedica en Red; CIBERDEM; Consejo Superior de
   Investigaciones Cientificas (CSIC); CSIC-UVA - Instituto de Biologia y
   Genetica Molecular (IBGM)
RP Valverde, AM (corresponding author), Inst Invest Biomed Alberto Sols, C Arturo Duperier 4, Madrid 28029, Spain.
EM avalverde@iib.uam.es
RI Balsinde, Jesús/C-7833-2018; González-Rodríguez, Águeda/O-6990-2018;
   Pardo Marques, Virginia/B-3062-2015
OI Guijas, Carlos/0000-0001-7993-3388; Martinez Valverde,
   Angela/0000-0003-1192-9045; Pardo Marques, Virginia/0000-0001-9787-8722;
   Gonzalez-Rodriguez, Agueda/0000-0003-2851-2318; Balsinde,
   Jesus/0000-0002-4157-6714
FU Ministerio de Economia y Competitividad, Spain [SAF2012-33283,
   SAF2013-48201-R]; Comunidad de Madrid (Spain) [S2010/BMD-2423]; European
   Foundation for the Studies of Diabetes and Amylin Paul Langerhans grant;
   Centro de Investigacion Biomedica en Red de Diabetes y Enfermedades
   Metabolicas Asociadas (CIBERDEM, Instituto de Salud Carlos III, Spain);
   CIBERDEM (ISCIII) postdoctoral contract
FX This work was supported by Ministerio de Economia y Competitividad,
   Spain, Grants SAF2012-33283 and SAF2013-48201-R; Comunidad de Madrid
   Grant S2010/BMD-2423 (Spain); an European Foundation for the Studies of
   Diabetes and Amylin Paul Langerhans grant; and the Centro de
   Investigacion Biomedica en Red de Diabetes y Enfermedades Metabolicas
   Asociadas (CIBERDEM, Instituto de Salud Carlos III, Spain). Holder of a
   CIBERDEM (ISCIII) postdoctoral contract. To whom correspondence may be
   addressed: Instituto de Investigaciones Biomedicas Alberto Sols,
   C/Arturo Duperier 4, 28029 Madrid, Spain. Tel.: 34-915854497; Fax:
   34-915854401; E-mail: aguedagr@iib.uam.es.
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NR 75
TC 47
Z9 50
U1 0
U2 12
PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
PI ROCKVILLE
PA 11200 ROCKVILLE PIKE, SUITE 302, ROCKVILLE, MD, UNITED STATES
SN 0021-9258
EI 1083-351X
J9 J BIOL CHEM
JI J. Biol. Chem.
PD MAY 1
PY 2015
VL 290
IS 18
BP 11663
EP 11677
DI 10.1074/jbc.M115.649483
PG 15
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA CH0OA
UT WOS:000353719400040
PM 25792746
OA Green Published
DA 2025-06-11
ER

PT J
AU Wiszniewski, M
   Caldareri, L
   Mori, D
   Calejman, CM
   Cymeryng, CB
   Repetto, EM
AF Wiszniewski, Morena
   Caldareri, Lilian
   Mori, Diego
   Calejman, Camila Martinez
   Cymeryng, Cora B.
   Repetto, Esteban M.
TI Exploring the impact of caloric restriction on molecular mechanisms of
   liver damage induced by sucrose intake in the drinking water
SO BRITISH JOURNAL OF NUTRITION
LA English
DT Article
DE Caloric restriction; Steatohepatitis; Liver metabolism; Inflammation;
   Unfolded protein response; Oxidative stress
ID UNFOLDED PROTEIN RESPONSE; FATTY LIVER; INSULIN-RESISTANCE; METABOLIC
   SYNDROME; DISEASE; FRUCTOSE; SUGAR; CARBOHYDRATE; INFLAMMATION;
   BEVERAGES
AB A positive association has been demonstrated between consumption of sucrose-sweetened beverages and the prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD). Since the administration of 30 % sucrose in the drinking water (sucrose-rich diet (SRD)) to rats has proven to be a good model of systemic insulin resistance, the aim of our study was to analyse the effect of caloric restriction applied on SRD-treated rats by switching back to a standard diet, on liver morphology, function and metabolism. Consumption of an SRD causes a metabolic shift towards gluconeogenesis and fatty acid synthesis leading to an increase in TAG levels in plasma and in the liver that were associated with a decrease in insulin sensitivity. Moreover, our results show that animals fed an SRD develop steatohepatitis characterised by the generation of oxidative stress, endoplasmic reticulum (ER) stress, inflammation and apoptosis. Although no histological changes were observed after a 2-week caloric restriction, key pathways associated with the progression of MASLD as inflammation, ER stress and apoptosis were slowed down. Notably, this 2-week intervention also increased liver insulin sensitivity (evaluated by AKT activity in this tissue) and drove the lipid metabolic profile towards oxidation, thus lowering circulating TAG levels. In summary, the present study uncovers underlying mechanisms affected, and their metabolic consequences, during the first stages of the phenotypic reversal of steatohepatitis by switching back to a standard diet after receiving sucrose-sweetened water for several weeks.
C1 [Wiszniewski, Morena; Caldareri, Lilian; Mori, Diego; Calejman, Camila Martinez; Cymeryng, Cora B.; Repetto, Esteban M.] Univ Buenos Aires, Ctr Estudios Farmacol & Bot CEFYBO, Lab Endocrinol Mol, CONICET, Buenos Aires, Argentina.
   [Wiszniewski, Morena] Univ Buenos Aires, Fac Odontol, Catedra Bioquim & Biol Bucal, Buenos Aires, Argentina.
   [Cymeryng, Cora B.] Univ Buenos Aires, Fac Med, Dept Bioquim Humana, Catedra Bioquim Humana 1, Buenos Aires, Argentina.
   [Repetto, Esteban M.] Univ Buenos Aires, Fac Farm & Bioquim, Dept Bioquim Clin, Catedra Bioquim Clin 1, Buenos Aires, Argentina.
C3 Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET);
   University of Buenos Aires; University of Buenos Aires; University of
   Buenos Aires; University of Buenos Aires
RP Repetto, EM (corresponding author), Univ Buenos Aires, Ctr Estudios Farmacol & Bot CEFYBO, Lab Endocrinol Mol, CONICET, Buenos Aires, Argentina.; Repetto, EM (corresponding author), Univ Buenos Aires, Fac Farm & Bioquim, Dept Bioquim Clin, Catedra Bioquim Clin 1, Buenos Aires, Argentina.
EM erepetto@fmed.uba.ar
OI Wiszniewski, Morena/0000-0003-2191-981X
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NR 70
TC 0
Z9 0
U1 3
U2 3
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1145
EI 1475-2662
J9 BRIT J NUTR
JI Br. J. Nutr.
PD DEC 28
PY 2024
VL 132
IS 12
BP 1562
EP 1574
DI 10.1017/S0007114524002794
EA NOV 2024
PG 13
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA Q9X7R
UT WOS:001369280300001
PM 39526462
OA Bronze
DA 2025-06-11
ER

PT J
AU Ojeda, ML
   Nogales, F
   Romero-Herrera, I
   Carreras, O
AF Luisa Ojeda, Maria
   Nogales, Fatima
   Romero-Herrera, Ines
   Carreras, Olimpia
TI Fetal Programming Is Deeply Related to Maternal Selenium Status and
   Oxidative Balance; Experimental Offspring Health Repercussions
SO NUTRIENTS
LA English
DT Review
DE selenium; oxidative stress; fetal programming; selenoproteins; fetal
   alcohol spectrum disorders; intrauterine growth retardation
ID PROTECTS TROPHOBLAST CELLS; FOR-GESTATIONAL-AGE; GLUTATHIONE-PEROXIDASE;
   METABOLIC SYNDROME; ETHANOL EXPOSURE; FOLIC-ACID; ALCOHOL EXPOSURE;
   INTESTINAL TRANSPORT; FEMALE REPRODUCTION; PRENATAL EXPOSURE
AB Nutrients consumed by mothers during pregnancy and lactation can exert permanent effects upon infant developing tissues, which could represent an important risk factor for diseases during adulthood. One of the important nutrients that contributes to regulating the cell cycle and tissue development and functionality is the trace element selenium (Se). Maternal Se requirements increase during gestation and lactation. Se performs its biological action by forming part of 25 selenoproteins, most of which have antioxidant properties, such as glutathione peroxidases (GPxs) and selenoprotein P (SELENOP). These are also related to endocrine regulation, appetite, growth and energy homeostasis. In experimental studies, it has been found that low dietary maternal Se supply leads to an important oxidative disruption in dams and in their progeny. This oxidative stress deeply affects gestational parameters, and leads to intrauterine growth retardation and abnormal development of tissues, which is related to endocrine metabolic imbalance. Childhood pathologies related to oxidative stress during pregnancy and/or lactation, leading to metabolic programing disorders like fetal alcohol spectrum disorders (FASD), have been associated with a low maternal Se status and intrauterine growth retardation. In this context, Se supplementation therapy to alcoholic dams avoids growth retardation, hepatic oxidation and improves gestational and breastfeeding parameters in FASD pups. This review is focused on the important role that Se plays during intrauterine and breastfeeding development, in order to highlight it as a marker and/or a nutritional strategy to avoid diverse fetal programming disorders related to oxidative stress.
C1 [Luisa Ojeda, Maria; Nogales, Fatima; Romero-Herrera, Ines; Carreras, Olimpia] Univ Seville, Fac Pharm, Dept Physiol, Seville 41012, Spain.
C3 University of Sevilla
RP Nogales, F (corresponding author), Univ Seville, Fac Pharm, Dept Physiol, Seville 41012, Spain.
EM ojedamuri11@us.es; fnogales@us.es; inesrh@hotmail.es; olimpia@us.es
RI Nogales, F/B-8562-2019; Romero Herrera, Inés/JPX-8714-2023; Ojeda,
   Luisa/B-8571-2019; Carreras, olimpia/P-9078-2019
OI Nogales, Fatima/0000-0003-4844-2740; ROMERO HERRERA,
   INES/0000-0001-5394-1849; Maria Luisa, Ojeda
   Murillo/0000-0002-9160-2749; Carreras, Olimpia/0000-0002-3858-0165
FU Andalusian Regional Government [2017/CTS-193, 2019/CTS-193]
FX The research recompiled in this review was funded by Andalusian Regional
   Government for its support to CTS-193 research group (2017/CTS-193 and
   2019/CTS-193).
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NR 188
TC 18
Z9 20
U1 1
U2 15
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JUN
PY 2021
VL 13
IS 6
AR 2085
DI 10.3390/nu13062085
PG 24
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA SY8MQ
UT WOS:000666135500001
PM 34207090
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Lee, DH
   Han, DH
   Nam, KT
   Park, JS
   Kim, SH
   Lee, M
   Kim, G
   Min, BS
   Cha, BS
   Lee, YS
   Sung, SH
   Jeong, H
   Ji, HW
   Lee, MJ
   Lee, JS
   Lee, HY
   Chun, Y
   Kim, J
   Komatsu, M
   Lee, YH
   Bae, SH
AF Lee, Da Hyun
   Han, Dai Hoon
   Nam, Ki Taek
   Park, Jeong Su
   Kim, Soo Hyun
   Lee, Milim
   Kim, Gyuri
   Min, Byung Soh
   Cha, Bong-Soo
   Lee, Yu Seol
   Sung, Su Haeng
   Jeong, Haengdueng
   Ji, Hye Won
   Lee, Moon Joo
   Lee, Jae Sung
   Lee, Hui-Young
   Chun, Yoomi
   Kim, Joungmok
   Komatsu, Masaaki
   Lee, Yong-ho
   Bae, Soo Han
TI Ezetimibe, an NPC1L1 inhibitor, is a potent Nrf2 activator that protects
   mice from diet-induced nonalcoholic steatohepatitis
SO FREE RADICAL BIOLOGY AND MEDICINE
LA English
DT Article
DE NAFLD; Ezetimibe; Nrf2; P62; AMPK; NASH
ID FATTY LIVER-DISEASE; TRANSCRIPTION FACTOR NRF2; INSULIN-RESISTANCE;
   METABOLIC SYNDROME; HEPATIC STEATOSIS; ANTIOXIDANT RESPONSE; SELECTIVE
   AUTOPHAGY; KEAP1-NRF2 PATHWAY; CELL-GROWTH; THERAPY
AB Oxidative stress is important for the pathogenesis of nonalcoholic fatty liver disease (NAFLD), a chronic disease that ranges from hepatic steatosis to nonalcoholic steatohepatitis (NASH). The nuclear factor erythroid 2-related factor 2-Kelch-like ECH associated protein 1 (Nrf2-Keapl) pathway is essential for cytoprotection against oxidative stress. In this study, we found that oxidative stress or inflammatory biomarkers and TUNEL positive cells were markedly increased in NASH patients compared to normal or simple steatosis. In addition, we identified that the hepatic mRNA levels of Nrf2 target genes such as Nqo-1 and GSTA-1 were significantly increased in NASH patients. Ezetimibe, a drug approved by the Food and Drug Administration for the treatment of hypercholesterolemia, improves NAFLD and alleviates oxidative stress. However, the precise mechanism of its antioxidant function remains largely unknown. We now demonstrate that ezetimibe activates Nrf2-Keapl pathway which was dependent of autophagy adaptor protein p62, without causing cytotoxicity. Ezetimibe activates AMP-activated protein kinase (AMPK), which in turn phosphorylates p62 (p-S351) via their direct interaction. Correspondingly, Ezetimibe protected liver cells from saturated fatty acid-induced apoptotic cell death through p62-dependent Nrf2 activation. Furthermore, its role as an Nrf2 activator was supported by methione- and choline-deficient (MCD) diet-induced NASH mouse model, showing that ezetimibe decreased the susceptibility of the liver to oxidative injury. These data demonstrate that the molecular mechanisms underlying ezetimibe's antioxidant role in the pathogenesis of NASH. (C) 2016 Elsevier Inc. All rights reserved.
C1 [Lee, Da Hyun; Nam, Ki Taek; Jeong, Haengdueng] Yonsei Univ, Brain Korea PLUS Project Med Sci 21, Seoul, South Korea.
   [Lee, Da Hyun; Nam, Ki Taek; Park, Jeong Su; Lee, Yu Seol; Sung, Su Haeng; Jeong, Haengdueng; Ji, Hye Won; Lee, Moon Joo; Bae, Soo Han] Yonsei Univ, Coll Med, Yonsei Biomed Res Inst, Severance Biomed Sci Inst, 50 Yonsei Ro, Seoul 03722, South Korea.
   [Han, Dai Hoon; Min, Byung Soh] Yonsei Univ, Coll Med, Dept Surg, 50-1 Yonsei Ro, Seoul 03722, South Korea.
   [Kim, Soo Hyun; Lee, Milim; Kim, Gyuri; Cha, Bong-Soo; Lee, Yong-ho] Yonsei Univ, Coll Med, Dept Internal Med, Div Endocrinol & Metab, 50-1 Yonsei Ro, Seoul 03722, South Korea.
   [Lee, Jae Sung; Lee, Hui-Young] Gachon Univ, Sch Med, Lee Gil Ya Canc & Diabet Inst, Dept Mol Med, Inchon 21999, South Korea.
   [Lee, Jae Sung; Lee, Hui-Young] Gachon Univ, Sch Med, Lee Gil Ya Canc & Diabet Inst, Korea Mouse Metab Phenotyping Ctr, Inchon 21999, South Korea.
   [Komatsu, Masaaki] Niigata Univ, Grad Sch Med & Dent Sci, Dept Biochem, Chuo Ku, Niigata 9518510, Japan.
   [Chun, Yoomi; Kim, Joungmok] Kyung Hee Univ, Sch Dent, Dept Oral Biochem & Mol Biol, Seoul 02447, South Korea.
C3 Yonsei University; Yonsei University; Yonsei University Health System;
   Yonsei University; Yonsei University Health System; Yonsei University;
   Yonsei University Health System; Gachon University; Gachon University;
   Niigata University; Kyung Hee University
RP Bae, SH (corresponding author), Yonsei Univ, Coll Med, Yonsei Biomed Res Inst, Severance Biomed Sci Inst, 50 Yonsei Ro, Seoul 03722, South Korea.; Lee, YH (corresponding author), Yonsei Univ, Coll Med, Dept Internal Med, Div Endocrinol & Metab, 50-1 Yonsei Ro, Seoul 03722, South Korea.
EM yholee@yuhs.ac; soohanbae@yuhs.ac
RI Lee, Joonseok/AFQ-8078-2022; Han, Dai/AAS-3726-2021; Lee,
   Hye/D-9081-2016; Lee, Yong-ho/AAT-4106-2020; Kim, Gyuri/E-8992-2018;
   Lee, HuiYoung/KLZ-6253-2024; Komatsu, Masaaki/B-8321-2011
OI Park, Jeong Su/0000-0003-4551-4294; Kim, Gyuri/0000-0002-2242-2816;
   Komatsu, Masaaki/0000-0001-7672-7722; Jeong,
   Haengdueng/0000-0002-9218-7372; Lee, Da Hyun/0000-0002-5412-6878; Han,
   Dai Hoon/0000-0003-2787-7876; Lee, Hui-Young/0000-0002-3464-6382; Cha,
   Bong-Soo/0000-0003-0542-2854; Lee, Yong-ho/0000-0002-6219-4942; Bae, Soo
   Han/0000-0002-8007-2906
FU National Research Foundation of Korea [NRF-2013R1A1A2059087,
   6-2014-0068]; Korea Health Technology R&D Project through the Korea
   Health Industry Development Institute (KHIDI); Ministry of Health &
   Welfare, Republic of Korea [HI16C0257, HI14C2476]; Basic Science
   Research Program through the National Research Foundation (NRF) of Korea
   - Ministry of Science, ICT & Future Planning [2015R1C1A1A01052558];
   Korea Mouse Phenotyping Center; Brain Korea 21 PLUS Project for Medical
   Science, Yonsei University; Bio and Medical Technology Development
   Program of the National Research Foundation (NRF) - Ministry of Science,
   ICT and Future Planning [NRF-2013M3A9D5072551]; Korea Healthcare
   Technology R&D Project, Ministry for Health, Welfare Family Affairs
   [HI14C1135]
FX This work was supported by the National Research Foundation of Korea
   (NRF-2013R1A1A2059087; S.H. Bae) and the (6-2014-0068; S.H. Bae). It was
   also supported by a grant of the Korea Health Technology R&D Project
   through the Korea Health Industry Development Institute (KHIDI), funded
   by the Ministry of Health & Welfare, Republic of Korea (HI16C0257; S.H.
   Bae and HI14C2476; Y. H. Lee) and Basic Science Research Program through
   the National Research Foundation (NRF) of Korea funded by the Ministry
   of Science, ICT & Future Planning (2015R1C1A1A01052558; Y.H. Lee). It
   was also supported by the Korea Mouse Phenotyping Center, and the Brain
   Korea 21 PLUS Project for Medical Science, Yonsei University, the Bio
   and Medical Technology Development Program of the National Research
   Foundation (NRF) funded by the Ministry of Science, ICT and Future
   Planning (NRF-2013M3A9D5072551; K.T. Nam). The Korea Healthcare
   Technology R&D Project, Ministry for Health, Welfare & Family Affairs
   (HI14C1135; H.Y. Lee).
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NR 42
TC 72
Z9 76
U1 1
U2 37
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0891-5849
EI 1873-4596
J9 FREE RADICAL BIO MED
JI Free Radic. Biol. Med.
PD OCT
PY 2016
VL 99
BP 520
EP 532
DI 10.1016/j.freeradbiomed.2016.09.009
PG 13
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA EC3AD
UT WOS:000387995400048
PM 27634173
DA 2025-06-11
ER

PT J
AU Kumei, S
   Yuhki, KI
   Kojima, F
   Kashiwagi, H
   Imamichi, Y
   Okumura, T
   Narumiya, S
   Ushikubi, F
AF Kumei, Shima
   Yuhki, Koh-Ichi
   Kojima, Fumiaki
   Kashiwagi, Hitoshi
   Imamichi, Yoshitaka
   Okumura, Toshikatsu
   Narumiya, Shuh
   Ushikubi, Fumitaka
TI Prostaglandin I2 suppresses the development of diet-induced
   nonalcoholic steatohepatitis in mice
SO FASEB JOURNAL
LA English
DT Article
DE Kupffer cell; NASH; oxidative stress
ID FATTY LIVER-DISEASE; SINUSOIDAL ENDOTHELIAL-CELLS; PROSTANOID RECEPTORS;
   OXIDATIVE STRESS; COX-2 INDUCTION; KUPFFER CELLS; MOUSE MODEL;
   PROSTACYCLIN; LACKING; IRON
AB Nonalcoholic steatohepatitis (NASH) is a hepatic manifestation of metabolic syndrome. Although the prostaglandin (PG)I2 receptor IP is expressed broadly in the liver, the role of PGI2-IP signaling in the development of NASH remains to be determined. Here, we investigated the role of the PGI2-IP system in the development of steatohepatitis using mice lacking the PGI2 receptor IP [IP-knockout (IP-KO) mice] and beraprost (BPS), a specific IP agonist. IP-KO and wild-type (WT) mice were fed a methionine-and choline-deficient diet (MCDD) for 2, 5, or 10 wk. BPS was administered orally to mice every day during the experimental periods. The effect of BPS on the expression of chemokine and inflammatory cytokines was examined also in cultured Kupffer cells. WT mice fed MCDD developed steatohepatitis at 10 wk. IP-KO mice developed steatohepatitis at 5 wk with augmented histologic derangements accompanied by increased hepatic monocyte chemoattractant protein-1 (MCP-1) and TNF-a concentrations. After 10 wk of MCDD, IP-KO mice had greater hepatic iron deposition with prominent oxidative stress, resulting in hepatocyte damage. In WT mice, BPS improved histologic and biochemical parameters of steatohe-patitis, accompanied by reduced hepatic concentration of MCP-1 and TNF-alpha. Accordingly, BPS suppressed the LPS-stimulated Mcp-1 and Tnf-a mRNA expression in cultured Kupffer cells prepared from WT mice. PGI2-IP signaling plays a crucial role in the development and progression of steatohepatitis by modulating the inflammatory response, leading to augmented oxidative stress. We suggest that the PGI2-IP system is an attractive therapeutic target for treating patients with NASH.
C1 [Kumei, Shima; Yuhki, Koh-Ichi; Kojima, Fumiaki; Kashiwagi, Hitoshi; Imamichi, Yoshitaka; Ushikubi, Fumitaka] Asahikawa Med Univ, Dept Pharmacol, Asahikawa, Hokkaido, Japan.
   [Kumei, Shima; Okumura, Toshikatsu] Asahikawa Med Univ, Dept Gen Med, Asahikawa, Hokkaido, Japan.
   [Narumiya, Shuh] Kyoto Univ, Fac Med, Dept Pharmacol, Kyoto, Japan.
C3 Asahikawa Medical College; Asahikawa Medical College; Kyoto University
RP Ushikubi, F (corresponding author), Asahikawa Med Univ, Midorigaoka Higashi 2-1-1-1, Asahikawa, Hokkaido 0788510, Japan.
EM ushikubi@asahikawa-med.ac.jp
OI Kashiwagi, Hitoshi/0000-0001-6385-9988; Okumura,
   Toshikatsu/0000-0003-1810-007X
FU Core Research for Evolutional Science and Technology (CREST) of Japan
   Science and Technology Agency [15gm0410006h0106]; Smoking Research
   Foundation
FX The authors thank Y. Watanabe and T. Yokoyama for help in breeding and
   maintenance of mice; Y. Tomonari, T. Ohkubo, N. Niizeki, and T. Ito for
   assistance with the experiments; and Y. Takashima for secretarial help
   (all from Asahikawa Medical University). This work was supported by the
   Core Research for Evolutional Science and Technology (CREST) of Japan
   Science and Technology Agency (Grant 15gm0410006h0106), and by a grant
   from the Smoking Research Foundation. The authors declare no conflicts
   of interest.
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NR 56
TC 9
Z9 9
U1 0
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0892-6638
EI 1530-6860
J9 FASEB J
JI Faseb J.
PD MAY
PY 2018
VL 32
IS 5
BP 2354
EP 2365
DI 10.1096/fj.20170059OR
PG 12
WC Biochemistry & Molecular Biology; Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GG2MW
UT WOS:000432528000005
PM 29247122
DA 2025-06-11
ER

PT J
AU Fader, KA
   Nault, R
   Kirby, MP
   Markous, G
   Matthews, J
   Zacharewski, TR
AF Fader, Kelly A.
   Nault, Rance
   Kirby, Mathew P.
   Markous, Gena
   Matthews, Jason
   Zacharewski, Timothy R.
TI Convergence of hepcidin deficiency, systemic iron overloading, heme
   accumulation, and REV-ERBα/β activation in aryl hydrocarbon
   receptor-elicited hepatotoxicity
SO TOXICOLOGY AND APPLIED PHARMACOLOGY
LA English
DT Article
DE TCDD; NAFLD; Iron; Hepcidin; Heme; REV-ERB alpha/beta
ID HEPATIC GENE-EXPRESSION; HEREDITARY HEMOCHROMATOSIS;
   2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN TCDD; NONALCOHOLIC STEATOHEPATITIS;
   LIPID-PEROXIDATION; METABOLIC SYNDROME; LIVER-MICROSOMES; OXIDATIVE
   STRESS; CIRCADIAN CLOCK; TRANSGENIC MICE
AB Persistent aryl hydrocarbon receptor (AhR) agonists elicit dose-dependent hepatic lipid accumulation, oxidative stress, inflammation, and fibrosis in mice. Iron (Fe) promotes AhR-mediated oxidative stress by catalyzing reactive oxygen species (ROS) production. To further characterize the role of Fe in AhR-mediated hepatotoxicity, male C57BL/6 mice were orally gavaged with sesame oil vehicle or 0.01-30 mu g/kg 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) every 4 days for 28 days. Duodenal epithelial and hepatic RNA-Seq data were integrated with hepatic AhR ChIP-Seq, capillary electrophoresis protein measurements, and clinical chemistry analyses. TCDD dose-dependently repressed hepatic expression of hepcidin (Hamp and Hamp2), the master regulator of systemic Fe homeostasis, resulting in a 2.6-fold increase in serum Fe with accumulating Fe spilling into urine. Total hepatic Fe levels were negligibly increased while transferrin saturation remained unchanged. Furthermore, TCDD elicited dose-dependent gene expression changes in heme biosynthesis including the induction of aminolevulinic acid synthase 1 (Alas1) and repression of uroporphyrinogen decarboxylase (Urod), leading to a 50% increase in hepatic hemin and a 13.2-fold increase in total urinary porphyrins. Consistent with this heme accumulation, differential gene expression suggests that heme activated BACH1 and REV-ERB alpha/beta, causing induction of heme oxygenase 1 (Hmox1) and repression of fatty acid biosynthesis, respectively. Collectively, these results suggest that Hamp repression, Fe accumulation, and increased heme levels converge to promote oxidative stress and the progression of TCDD-elicited hepatotoxicity. (C) 2017 Elsevier Inc. All rights reserved.
C1 [Fader, Kelly A.; Nault, Rance; Kirby, Mathew P.; Markous, Gena; Zacharewski, Timothy R.] Michigan State Univ, Dept Biochem & Mol Biol, E Lansing, MI 48824 USA.
   [Fader, Kelly A.; Nault, Rance; Zacharewski, Timothy R.] Michigan State Univ, Inst Integrat Toxicol, E Lansing, MI 48824 USA.
   [Matthews, Jason] Univ Oslo, Inst Basic Med Sci, Dept Nutr, N-0316 Oslo, Norway.
C3 Michigan State University; Michigan State University; University of Oslo
RP Zacharewski, TR (corresponding author), Michigan State Univ, 603 Wilson Rd,Room 309, E Lansing, MI 48824 USA.
EM tzachare@msu.edu
RI Matthews, Jason/KJO-2216-2024
OI Fader, Kelly/0000-0002-8797-5577; Matthews, Jason/0000-0002-9815-8636
FU National Institute of Environmental Health Sciences Superfund Research
   Program [NIEHS] [SBRP P42ES049111]; AgBioResearch at Michigan State
   University; Canadian Institutes of Health Research Doctoral Foreign
   Study Award [DFS-140386]; National Institutes of Health Integrative
   Training in the Pharmacological Sciences Award [5T32GM092715]
FX This work was supported by the National Institute of Environmental
   Health Sciences Superfund Research Program [NIEHS SBRP P42ES049111 to
   TRZ. TRZ is partially supported by AgBioResearch at Michigan State
   University. KAF is supported by the Canadian Institutes of Health
   Research Doctoral Foreign Study Award [DFS-140386]. RN is supported by
   the National Institutes of Health Integrative Training in the
   Pharmacological Sciences Award [5T32GM092715].
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NR 68
TC 38
Z9 44
U1 0
U2 29
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0041-008X
EI 1096-0333
J9 TOXICOL APPL PHARM
JI Toxicol. Appl. Pharmacol.
PD APR 15
PY 2017
VL 321
BP 1
EP 17
DI 10.1016/j.taap.2017.02.006
PG 17
WC Pharmacology & Pharmacy; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Toxicology
GA EP4LL
UT WOS:000397351900001
PM 28213091
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Zhou, B
   Li, H
   Liu, J
   Xu, L
   Guo, Q
   Zang, W
   Sun, H
   Wu, S
AF Zhou, B.
   Li, H.
   Liu, J.
   Xu, L.
   Guo, Q.
   Zang, W.
   Sun, H.
   Wu, S.
TI Autophagic dysfunction is improved by intermittent administration of
   osteocalcin in obese mice
SO INTERNATIONAL JOURNAL OF OBESITY
LA English
DT Article
ID ENDOPLASMIC-RETICULUM STRESS; IMPAIRED INSULIN SENSITIVITY; DIET-INDUCED
   OBESITY; GROWTH-FACTOR 1; SERUM OSTEOCALCIN; EXPRESSION; GLUCOSE; CELL;
   DIFFERENTIATION; METABOLISM
AB BACKGROUND: Osteoblast-specific secreted osteocalcin has been considered as an important regulator of energy and glucose metabolism, however, the causative role and clinical potential of osteocalcin implicated in insulin resistance remains not fully understood.
   METHODS: Osteocalcin was administered intermittently in vivo and in vitro, and metabolic parameters, autophagy and insulin signaling were assessed.
   RESULTS: The intermittent injections of osteocalcin in mice fed high-fat diet resulted in decreased body weight gain, fat-pad weight gain, serum triglycerides, serum-free fatty acid, blood glucose, insulin level and partial normalization of glucose tolerance relative to the mice fed high-fat diet and received vehicle injections. Meanwhile, the intermittent administration of osteocalcin not only led to the alleviation of autophagic dysfunction and endoplasmic reticulum (ER) stress, but also contributed to the restoration of the impaired insulin signaling in adipose tissue and skeleton muscle of mice consumed the high-fat diet. In accordance with these findings in vivo, osteocalcin treatment also displayed a protective impact on adipocytes and myocytes against tunicamycinor palmitate-induced ER stress and autophagy dysfunction in an XBP-1-independent manner, with these effects of osteocalcin being reversed by inhibition of mammalian target of rapamycin (mTOR) or nuclear factor-kappa B (NF-kappa B).
   CONCLUSIONS: Intermittent administration of osteocalcin efficiently reversed the attenuated autophagy and ER stress, and restored the impaired insulin sensitivity in cellular and mice models of insulin resistance. Our findings provide new insights into the clinical potential of osteocalcin in metabolic homeostasis, and suggest an innovative strategy for the treatment against diabetes, obesity and metabolic syndrome.
C1 Xi An Jiao Tong Univ, Sch Med, Affiliated Hosp 1, Xian 710061, Shaanxi, Peoples R China.
   Xi An Jiao Tong Univ, Sch Med, Minist Educ, Key Lab Environm & Genes Related Dis, Xian 710061, Shaanxi, Peoples R China.
C3 Xi'an Jiaotong University; Ministry of Education - China; Xi'an Jiaotong
   University
RP Sun, H; Wu, S (corresponding author), Xi An Jiao Tong Univ, Sch Med, Affiliated Hosp 1, Ctr Translat Med, 277 Yanta West Rd, Xian 710061, Shaanxi, Peoples R China.
EM sunhongzhi@mail.xjtu.edu.cn; shufangw@hotmail.com
OI Zhou, Bo/0000-0003-1467-6565
FU National Natural Science Foundation of China [30930105, 30971392,
   81071440, 81170741, 81370899, 81472038, 81500016]; National Excellent
   Young Scientist Program [81222026]; New Century Excellent Talents in
   University from the Ministry of Education, China [NCET-08-0435]
FX We appreciate the technical support from the electron microscope center
   of Xi'an Jiaotong University. This work was supported by the programs
   from the National Natural Science Foundation of China (general program
   no. 30930105, no. 30971392, no. 81071440, no. 81170741, no. 81370899,
   no. 81472038 and no. 81500016), National Excellent Young Scientist
   Program (no. 81222026) and the New Century Excellent Talents in
   University from the Ministry of Education, China (NCET-08-0435).
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NR 39
TC 21
Z9 23
U1 0
U2 12
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0307-0565
EI 1476-5497
J9 INT J OBESITY
JI Int. J. Obes.
PD MAY
PY 2016
VL 40
IS 5
BP 833
EP 843
DI 10.1038/ijo.2016.1
PG 11
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA DO2NK
UT WOS:000377616500015
PM 26740123
DA 2025-06-11
ER

PT J
AU Rantanen, AT
   Kallio, MM
   Korkeila, JJA
   Kautiainen, H
   Korhonen, PE
AF Rantanen, Ansa Talvikki
   Kallio, Mika Martin
   Korkeila, Jyrki Jaakko Antero
   Kautiainen, Hannu
   Korhonen, Paivi Elina
TI Relationship of non-melancholic and melancholic depressive symptoms with
   all-cause mortality: A prospective study in a primary care population
SO JOURNAL OF PSYCHOSOMATIC RESEARCH
LA English
DT Article
DE All-cause mortality; Beck's depression inventory; Melancholic depressive
   symptoms; Non-melancholic depressive symptoms
ID CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; PHYSICAL-ACTIVITY; 10-YEAR
   RISK; METAANALYSIS; ASSOCIATION; SUBTYPES; NONADHERENCE; PARTICIPANTS;
   INFLAMMATION
AB Objective: To assess relationship of non-melancholic and melancholic subtypes of depressive symptoms with all-cause mortality among cardiovascular risk persons.
   Methods: A population-based prospective study of 2522 Finnish middle-aged persons with elevated cardiovascular risk was conducted. Depressive symptoms were assessed by the Beck's Depression Inventory. Data on mortality were obtained from The Official Statistics of Finland after 11-year follow-up.
   Results: At baseline, the prevalence of non-melancholic and melancholic depressive symptoms was 14.9% and 5.2%, respectively. During the mean follow-up time of 11 years, 8.1% (n = 164) of those without, 13.9% (n = 52) of those with non-melancholic, and 10.7% (n = 14) of those with melancholic depressive symptoms died. Compared to non-depressive subjects, the hazard ratio for time to all-cause mortality was 1.67 (95% CI: 1.21-2.32, p = .002) in non-melancholically depressive and 1.01 (95% CI: 0.56-1.83, p = .97) in melancholically depressive subjects, when adjusted for age, gender, education, smoking, alcohol use, BMI, hypertension, dyslipidaemia, and glucose disorders. In comparison to the mortality rate in the general population throughout Finland over the same period, non-depressiveness was associated with a decreased standardized mortality rate.
   Conclusion: Non-melancholic depressive symptoms seem to be associated with excess all-cause mortality. In clinical settings, recognition of non-melancholic depressive symptoms should be emphasised.
C1 [Rantanen, Ansa Talvikki; Korhonen, Paivi Elina] Univ Turku, Dept Gen Practice, Turku, Finland.
   [Rantanen, Ansa Talvikki; Korkeila, Jyrki Jaakko Antero; Korhonen, Paivi Elina] Turku Univ Hosp, Turku, Finland.
   [Rantanen, Ansa Talvikki] Salo Hlth Ctr, Salo, Finland.
   [Kallio, Mika Martin; Korhonen, Paivi Elina] Cent Satakunta Hlth Federat Municipal, Harjavalta, Finland.
   [Korkeila, Jyrki Jaakko Antero] Univ Turku, Dept Psychiat, Turku, Finland.
   [Korkeila, Jyrki Jaakko Antero] Hosp Dist Satakunta, Dept Psychiat, Pori, Finland.
   [Kautiainen, Hannu] Folkhalsan Res Ctr, Helsinki, Finland.
   [Kautiainen, Hannu] Kuopio Univ Hosp, Unit Primary Hlth Care, Kuopio, Finland.
C3 University of Turku; University of Turku; University of Turku;
   Folkhalsan Research Center; Kuopio University Hospital; University of
   Eastern Finland; University of Eastern Finland Hospital
RP Rantanen, AT (corresponding author), ICT City, Joukahaisenkatu 3-5A, Turku 20520, Finland.
EM atsipp@utu.fi; Mika.Kallio@ksthky.fi; jyrkor@utu.fi;
   hanmt.kautiainen@medcare.fi; paikor@utu.fi
RI Rantanen, Ansa/HDM-6559-2022
OI Rantanen, Ansa/0000-0001-5639-4756
FU Central Satakunta Health Federation of Municipalities; Finnish
   Association of General Practice
FX This study was supported by the Central Satakunta Health Federation of
   Municipalities and by the Finnish Association of General Practice. The
   study funders played no role in the study.
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NR 58
TC 7
Z9 7
U1 0
U2 2
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-3999
EI 1879-1360
J9 J PSYCHOSOM RES
JI J. Psychosomat. Res.
PD JUN
PY 2020
VL 133
AR 110107
DI 10.1016/j.jpsychores.2020.110107
PG 7
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA MC5OH
UT WOS:000543335400009
PM 32276195
DA 2025-06-11
ER

PT J
AU Menegon, DB
   Pereira, AG
   Camerin, AC
   Cestari, T
AF Menegon, Doris B.
   Pereira, Ana G.
   Camerin, Anna C.
   Cestari, Tania
TI Psoriasis and comorbidities in a southern Brazilian population: a
   case-control study
SO INTERNATIONAL JOURNAL OF DERMATOLOGY
LA English
DT Article
ID QUALITY-OF-LIFE; METABOLIC SYNDROME; ALCOHOL-CONSUMPTION; RISK-FACTORS;
   SMOKING; PREVALENCE; ATHEROSCLEROSIS; DISEASE; EPIDEMIOLOGY; ASSOCIATION
AB BackgroundPsoriasis is a chronic disease with worldwide prevalences of 0.6-4.8%. Its inherent chronic inflammatory component predisposes patients to cardiovascular and metabolic diseases.
   ObjectivesThis study aimed to evaluate the associations of psoriasis with comorbidities and health risk factors such as smoking and alcohol intake, and to examine demographic differences in its occurrence in a southern Brazil population.
   MethodsA case-control study was conducted at the Hospital de Clinicas de Porto Alegre between April 2009 and March 2011. The sample comprised 350 patients with psoriasis and 346 healthy control subjects. Data were collected using a standardized questionnaire. Tobacco load and alcohol consumption per person were investigated. Physical examination included blood pressure, waist circumference (WC), and body mass index (BMI) calculation. Clinical evaluation investigated whether psoriasis was localized or widespread and the percentage of body surface area (BSA) affected.
   ResultsPsoriasis patients exhibited an increased WC (P<0.01) and BMI (P=0.01) and higher incidences of smoking (P<0.01) and depression (P<0.01) than control subjects. A comparison of patients with involvement of <20% and >20% of BSA revealed significant differences in prevalences of hypertension (P=0.03) and diabetes (P<0.01).
   ConclusionsThe present study demonstrated higher incidences of depression, increased WC, overweight, obesity, and smoking in psoriasis patients compared with controls. Patients with >20% of BSA affected were 1.69 times more likely to have hypertension and 2.9 times more likely to have diabetes. Healthcare providers should be alert to the increased cardiovascular risk and metabolic specificities of patients with psoriasis. Appropriate information on healthy lifestyle habits, including maintenance of a healthy weight and participation in physical exercise, and avoidance of alcohol and smoking are fundamental.
C1 [Menegon, Doris B.; Camerin, Anna C.; Cestari, Tania] Univ Fed Rio Grande do Sul, Sch Med, Porto Alegre, RS, Brazil.
   [Menegon, Doris B.; Cestari, Tania] Hosp Clin Porto Alegre, Dept Dermatol, BR-90035903 Porto Alegre, RS, Brazil.
   [Menegon, Doris B.] Hosp Clin Porto Alegre, Publ Hlth Nursing Serv, BR-90035903 Porto Alegre, RS, Brazil.
   [Camerin, Anna C.] Univ Fed Rio Grande do Sul, Sch Nursing, Porto Alegre, RS, Brazil.
C3 Universidade Federal do Rio Grande do Sul; Hospital de Clinicas de Porto
   Alegre; Hospital de Clinicas de Porto Alegre; Universidade Federal do
   Rio Grande do Sul
RP Menegon, DB (corresponding author), Hosp Clin Porto Alegre, Publ Hlth Nursing Serv, Ramiro Barcelos 2350, BR-90035903 Porto Alegre, RS, Brazil.
EM dmenegon@hcpa.ufrgs.br
RI Cestari, Tania/U-4385-2019
FU Fundo de Incentivo a Pesquisa (FIPE) of Hospital de Clinicas de Porto
   Alegre (HCPA); National Council of Technological and Scientific
   Development (Conselho Nacional de Desenvolvimento Cientifico e
   Tecnologico [CNPq]) of Brazil
FX Fundo de Incentivo a Pesquisa (FIPE) of Hospital de Clinicas de Porto
   Alegre (HCPA) and National Council of Technological and Scientific
   Development (Conselho Nacional de Desenvolvimento Cientifico e
   Tecnologico [CNPq]) of Brazil.
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NR 46
TC 17
Z9 17
U1 0
U2 12
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0011-9059
EI 1365-4632
J9 INT J DERMATOL
JI Int. J. Dermatol.
PD NOV
PY 2014
VL 53
IS 11
BP E518
EP E525
DI 10.1111/ijd.12186
PG 8
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA AS3KX
UT WOS:000344177600007
PM 25070669
DA 2025-06-11
ER

PT J
AU Alves, L
   Azevedo, A
   Silva, S
   Barros, H
AF Alves, Luis
   Azevedo, Ana
   Silva, Susana
   Barros, Henrique
TI Socioeconomic Inequalities in the Prevalence of Nine Established
   Cardiovascular Risk Factors in a Southern European Population
SO PLOS ONE
LA English
DT Article
ID MYOCARDIAL-INFARCTION; BLOOD-PRESSURE; MULTILEVEL ANALYSIS; METABOLIC
   SYNDROME; PHYSICAL-ACTIVITY; HEALTH; POSITION; DISEASE; ASSOCIATION;
   DETERMINANTS
AB The evaluation of the gender-specific prevalence of cardiovascular risk factors across socioeconomic position (SEP) categories may unravel mechanisms involved in the development of coronary heart disease. Using a sample of 1704 community dwellers of a Portuguese urban center aged 40 years or older, assessed in 1999-2003, we quantified the age-standardized prevalence of nine established cardiovascular risk factors (diabetes mellitus, hypertension, hypercholesterolemia, smoking, sedentariness, abdominal obesity, poor diet, excessive alcohol intake and depression) across SEP and gender categories. Data on individual education and occupation were collected by questionnaire and used to characterize SEP. The prevalence of seven out of nine well-established risk factors was higher in men. Among women, the prevalence of most of the studied risk factors was higher in lower SEP groups. The main exception was smoking, which increased with education and occupation levels. Among men, socioeconomic gradients were less clear, but lower SEP was associated with a higher prevalence of diabetes, excessive alcohol intake and depression in a graded mode. The historical cultural beliefs and practices captured throughout the lifecourse frame the wide socioeconomic gradients discernible in our study conducted in an unequal European developed population. While men were more exposed to most risk factors, the clearer associations between SEP and risk factors among women support that their adoption of particular healthy behaviors is more dependent on material and symbolic conditions. To fully address the issue of health inequalities, interventions within the health systems should be complemented with population-based policies specifically designed to reduce socioeconomic gradients.
C1 [Alves, Luis; Azevedo, Ana; Silva, Susana; Barros, Henrique] Univ Porto, Sch Med, Dept Clin Epidemiol Predict Med & Publ Hlth, P-4100 Oporto, Portugal.
   [Alves, Luis; Azevedo, Ana; Silva, Susana; Barros, Henrique] Univ Porto ISPUP, Inst Publ Hlth, Oporto, Portugal.
   Santo Andre de Canidelo Hlth Family Unit, Vila Nova De Gaia, Portugal.
C3 Universidade do Porto; Universidade do Porto
RP Alves, L (corresponding author), Univ Porto, Sch Med, Dept Clin Epidemiol Predict Med & Publ Hlth, Rua Campo Alegre 823, P-4100 Oporto, Portugal.
EM lalves@med.up.pt
RI Barros, Henrique/A-5488-2008; Fontes-Carvalho, Ricardo/AAQ-6131-2020;
   Silva, Susana/HGB-0984-2022; Alves, Luis/C-1618-2018
OI Silva, Susana/0000-0002-1335-8648; Alves, Luis/0000-0001-5855-2754;
   Barros, Henrique/0000-0003-4699-6571; Azevedo, Ana/0000-0002-7368-9609
FU Fundacao para a Ciencia e a Tecnologia (Foundation for Science and
   Technology) [POCI/SAU-ESP/61160/2004]; Fundação para a Ciência e a
   Tecnologia [POCI/SAU-ESP/61160/2004] Funding Source: FCT
FX Funded by Fundacao para a Ciencia e a Tecnologia (Foundation for Science
   and Technology) (POCI/SAU-ESP/61160/2004)
   http://www.fct.mctes.pt/projectos/pub/2004/painel_result/vglobal_project
   o.asp?idProjecto=61160&idElemConcurso=34. The funders had no role in
   study design, data collection and analysis, decision to publish, or
   preparation of the manuscript.
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NR 66
TC 32
Z9 46
U1 0
U2 14
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAY 29
PY 2012
VL 7
IS 5
AR e37158
DI 10.1371/journal.pone.0037158
PG 9
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Science & Technology - Other Topics
GA 959WT
UT WOS:000305349600011
PM 22666343
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Seppälä, J
   Koponen, H
   Kautiainen, H
   Eriksson, JG
   Kampman, O
   Männistö, S
   Mäntyselkä, P
   Oksa, H
   Ovaskainen, Y
   Viikki, M
   Vanhala, M
AF Seppala, Jussi
   Koponen, Hannu
   Kautiainen, Hannu
   Eriksson, Johan G.
   Kampman, Olli
   Mannisto, Satu
   Mantyselka, Pekka
   Oksa, Heikki
   Ovaskainen, Yrjo
   Viikki, Merja
   Vanhala, Mauno
TI Association between folate intake and melancholic depressive symptoms. A
   Finnish population-based study
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Beck Depression Inventory; Folate intake; Melancholic depressive
   symptoms; Non-melancholic depressive symptoms; Population-based
ID METABOLIC SYNDROME; DIETARY-FOLATE; VITAMIN-B-12; HOMOCYSTEINE;
   DISORDERS; INVENTORY; FINLAND; WOMEN; RISK; MEN
AB Background: An association between low blood folate levels and depressive symptoms (DS) has been reported in several epidemiological studies, but no studies have examined folate intake in melancholic or non-melancholic DS in population-based samples.
   Methods: The aim of the study was to evaluate folate intake in DS with or without melancholic characteristics as a part of the Finnish diabetes prevention program (FIN-D2D). Altogether, 4500 randomly selected subjects aged 45-74 years were selected from the National Population Register. The study population (N = 2806, participation rate 62%) consisted of 1328 men and 1478 women. The health examinations were carried out in 2007 according to the WHO MONICA project. The assessment of DS was based on the Beck Depression Inventory (BDI, cutoff >= 10 points). A summary score of melancholic items in the BDI was used in dividing the participants with DS (N=429) into melancholic (N= 138) and non-melancholic DS (N = 291) subgroups. Folate intake was assessed using a validated food frequency questionnaire (FFQ).
   Results: DS associated linearly with gender specific tertiles of folate intake (p for linearity = 0.003). The OR for melancholic DS was 0.55 (95%Cl 0.34 to 0.90) for the high Waite of folate intake versus the low (p for linearity = 0.018), while the ORs for non-melancholic DS were nonsignificant.
   Limitations: Assessment of DS was based on a self-rating scale, and the population was in advanced middle-aged.
   Conclusions: A low folate intake was associated with DS through its effect on melancholic DS. (C) 2012 Elsevier B.V. All rights reserved.
C1 [Seppala, Jussi] S Savo Hosp Dist, Dept Psychiat, FIN-50520 Mikkeli, Finland.
   [Koponen, Hannu] Univ Eastern Finland, Inst Clin Med, Kuopio, Finland.
   [Koponen, Hannu] Kuopio Univ Hosp, Dept Psychiat, SF-70210 Kuopio, Finland.
   [Kautiainen, Hannu; Vanhala, Mauno] Cent Finland Cent Hosp, Unit Family Practice, Jyvaskyla, Finland.
   [Kautiainen, Hannu; Mantyselka, Pekka] Kuopio Univ Hosp, Unit Primary Hlth Care, SF-70210 Kuopio, Finland.
   [Eriksson, Johan G.] Univ Helsinki, Dept Gen Practice & Primary Hlth Care, Helsinki, Finland.
   [Eriksson, Johan G.] Univ Helsinki, Gen Hosp, Unit Gen Practice, Helsinki, Finland.
   [Eriksson, Johan G.; Mannisto, Satu] Natl Inst Hlth & Welf, Helsinki, Finland.
   [Eriksson, Johan G.] Folkhalsan Res Ctr, Helsinki, Finland.
   [Eriksson, Johan G.] Vasa Cent Hosp, Vaasa, Finland.
   [Kampman, Olli; Viikki, Merja] Univ Tampere, Sch Med, FIN-33101 Tampere, Finland.
   [Kampman, Olli] Seinajoki Hosp Dist, Dept Psychiat, Seinajoki, Finland.
   [Mantyselka, Pekka] Univ Eastern Finland, Unit Primary Hlth Care, Kuopio, Finland.
   [Oksa, Heikki] Tampere Univ Hosp, Tampere, Finland.
   [Ovaskainen, Yrjo] Diacor, Helsinki, Finland.
   [Viikki, Merja] Tampere Mental Hlth Ctr, Tampere, Finland.
   [Vanhala, Mauno] Univ Eastern Finland, Dept Family Med, Sch Publ Hlth & Clin Nutr, Kuopio, Finland.
   [Vanhala, Mauno] Kuopio Univ Hosp, Unit Family Practice, SF-70210 Kuopio, Finland.
C3 University of Eastern Finland; Kuopio University Hospital; University of
   Eastern Finland; University of Eastern Finland Hospital; Central Finland
   Central Hospital; University of Eastern Finland; University of Eastern
   Finland Hospital; Kuopio University Hospital; University of Helsinki;
   University of Helsinki; Finland National Institute for Health & Welfare;
   Folkhalsan Research Center; Vaasa Central Hospital; Tampere University;
   University of Eastern Finland; Tampere University; Tampere University
   Hospital; University of Eastern Finland; University of Eastern Finland;
   University of Eastern Finland Hospital; Kuopio University Hospital
RP Seppälä, J (corresponding author), S Savo Hosp Dist, Dept Psychiat, Moisiontie 10, FIN-50520 Mikkeli, Finland.
EM jussi.seppala@esshp.fi; hannu.koponen@kuh.fi;
   hannu.kautiainen@medcare.fi; johan.eriksson@helsinki.fi;
   olli.kampman@uta.fi; satu.mannisto@thl.fi; pekka.mantyselka@uef.fi;
   heikki.oksa@pshp.fi; yrjo.ovaskainen@kolumbus.fi; merja.viikki@uta.fi;
   mauno.vanhala@ksshp.fi
RI Gibbs, J. Raphael/A-3984-2010; Kampman, Olli/AAW-2352-2021
OI Mannisto, Satu/0000-0002-8668-3046; Kampman, Olli/0000-0001-6891-2266;
   Eriksson, Johan/0000-0002-2516-2060
FU Pirkanmaa; Southern Ostrobothnia; North Ostrobothnia; Central Finland
   and Northern Savo; Finnish National Public Health Institute; Finnish
   Diabetes Association; Ministry of Social Affairs and Health in Finland
   and Finland's Slot Machine Association
FX FIN-D2D was supported by financing from the hospital districts of
   Pirkanmaa, Southern Ostrobothnia, North Ostrobothnia, Central Finland
   and Northern Savo, the Finnish National Public Health Institute, the
   Finnish Diabetes Association, the Ministry of Social Affairs and Health
   in Finland and Finland's Slot Machine Association. Funding for the study
   had no further role in study design; in the collection, analysis and
   interpretation of data: in the writing of the report; and in the
   decision to submit the paper for publication.
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NR 43
TC 14
Z9 14
U1 0
U2 8
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD MAY
PY 2012
VL 138
IS 3
BP 473
EP 478
DI 10.1016/j.jad.2012.01.007
PG 6
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA 924AW
UT WOS:000302663900033
PM 22353381
DA 2025-06-11
ER

PT J
AU Grech, O
   Sassani, M
   Terwindt, G
   Lavery, GG
   Mollan, SP
   Sinclair, AJ
AF Grech, Olivia
   Sassani, Matilde
   Terwindt, Gisela
   Lavery, Gareth G.
   Mollan, Susan P.
   Sinclair, Alexandra J.
TI Alterations in metabolic flux in migraine and the translational
   relevance
SO JOURNAL OF HEADACHE AND PAIN
LA English
DT Review
DE Headache; Migraine; Metabolism; CGRP; Metabolic disorders;
   Nutraceuticals; Obesity; Glucose metabolism
ID GENE-RELATED PEPTIDE; IDIOPATHIC INTRACRANIAL HYPERTENSION; CORTICAL
   SPREADING DEPRESSION; RANDOMIZED CONTROLLED-TRIAL; CGRP RECEPTOR
   ANTAGONIST; MUSCLE ENERGY-METABOLISM; HIGH-DOSE RIBOFLAVIN;
   QUALITY-OF-LIFE; DOUBLE-BLIND; RESONANCE-SPECTROSCOPY
AB Background Migraine is a highly prevalent disorder with significant economical and personal burden. Despite the development of effective therapeutics, the causes which precipitate migraine attacks remain elusive. Clinical studies have highlighted altered metabolic flux and mitochondrial function in patients. In vivo animal experiments can allude to the metabolic mechanisms which may underlie migraine susceptibility. Understanding the translational relevance of these studies are important to identifying triggers, biomarkers and therapeutic targets in migraine. Main body Functional imaging studies have suggested that migraineurs feature metabolic syndrome, exhibiting hallmark features including upregulated oxidative phosphorylation yet depleted available free energy. Glucose hypometabolism is also evident in migraine patients and can lead to altered neuronal hyperexcitability such as the incidence of cortical spreading depression (CSD). The association between obesity and increased risk, frequency and worse prognosis of migraine also highlights lipid dysregulation in migraine pathology. Calcitonin gene related peptide (CGRP) has demonstrated an important role in sensitisation and nociception in headache, however its role in metabolic regulation in connection with migraine has not been thoroughly explored. Whether impaired metabolic function leads to increased release of peptides such as CGRP or excessive nociception leads to altered flux is yet unknown. Conclusion Migraine susceptibility may be underpinned by impaired metabolism resulting in depleted energy stores and altered neuronal function. This review discusses both clinical and in vivo studies which provide evidence of altered metabolic flux which contribute toward pathophysiology. It also reviews the translational relevance of animal studies in identifying targets of biomarker or therapeutic development.
C1 [Grech, Olivia; Sassani, Matilde; Sinclair, Alexandra J.] Univ Birmingham, Coll Med & Dent Sci, Inst Metab & Syst Res, Metab Neurol, Birmingham B15 2TT, W Midlands, England.
   [Sassani, Matilde; Sinclair, Alexandra J.] Univ Hosp Birmingham NHS Fdn Trust, Dept Neurol, Birmingham B15 2GW, W Midlands, England.
   [Terwindt, Gisela] Leiden Univ, Med Ctr, Dept Neurol, NL-2333 ZA Leiden, Netherlands.
   [Lavery, Gareth G.] Nottingham Trent Univ, Sch Sci & Technol, Dept Biosci, Clifton Campus, Nottingham NG11 8NS, England.
   [Mollan, Susan P.] Univ Hosp Birmingham, Queen Elizabeth Hosp, Birmingham Neuro Ophthalmol, Birmingham B15 2GW, W Midlands, England.
C3 University of Birmingham; University of Birmingham; Leiden University -
   Excl LUMC; Leiden University; Leiden University Medical Center (LUMC);
   Nottingham Trent University; University of Birmingham
RP Sinclair, AJ (corresponding author), Univ Birmingham, Coll Med & Dent Sci, Inst Metab & Syst Res, Metab Neurol, Birmingham B15 2TT, W Midlands, England.; Sinclair, AJ (corresponding author), Univ Hosp Birmingham NHS Fdn Trust, Dept Neurol, Birmingham B15 2GW, W Midlands, England.
EM a.b.sinclair@bham.ac.uk
RI Sassani, Matilde/AAJ-4369-2020; Grech, Olivia/AAU-9649-2021
OI Sassani, Matilde/0000-0002-0384-7296; Mollan, Susan/0000-0002-6314-4437
FU Brain Research UK PhD studentship; Dutch Brain Foundation; Dutch
   Research Council; Wellcome Trust Senior Fellowship [104612/Z/14/Z];
   National Institute for Health Research (NIHR) clinician scientist
   fellowship [NIHR-CS-011-028]; Medical Research Council, UK
   [MR/K015184/1]; Sir Jules Thorn Award for Biomedical Science
FX O.G is funded by a Brain Research UK PhD studentship. G.T reports
   funding from Dutch Brain Foundation, Dutch Research Council. GGL is
   supported by a Wellcome Trust Senior Fellowship (104612/Z/14/Z), A.J.S
   was funded by a National Institute for Health Research (NIHR) clinician
   scientist fellowship (NIHR-CS-011-028) and the Medical Research Council,
   UK (MR/K015184/1) for the duration of the study. A.J.S is funded by a
   Sir Jules Thorn Award for Biomedical Science.
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NR 130
TC 11
Z9 11
U1 0
U2 7
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1129-2369
EI 1129-2377
J9 J HEADACHE PAIN
JI J. Headache Pain
PD DEC
PY 2022
VL 23
IS 1
AR 127
DI 10.1186/s10194-022-01494-w
PG 12
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 4Z0GZ
UT WOS:000861899200001
PM 36175833
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Savransky, A
   Chiappelli, J
   Fisseha, F
   Wisner, KM
   Du, XM
   Mirmomen, SM
   Jones, AD
   Adhikari, BM
   Bruce, HA
   Rowland, LM
   Hong, LE
AF Savransky, Anya
   Chiappelli, Joshua
   Fisseha, Feven
   Wisner, Krista M.
   Du Xiaoming
   Mirmomen, S. Milad
   Jones, Aaron D.
   Adhikari, Bhim M.
   Bruce, Heather A.
   Rowland, Laura M.
   Hong, L. Elliot
TI Elevated allostatic load early in the course of schizophrenia
SO TRANSLATIONAL PSYCHIATRY
LA English
DT Article
ID DRUG-NAIVE PATIENTS; 1ST-EPISODE SCHIZOPHRENIA; METABOLIC SYNDROME;
   ANTIPSYCHOTIC TREATMENT; PREMATURE MORTALITY; PSYCHOTIC SYMPTOMS;
   GLUCOSE-TOLERANCE; HEALTHY CONTROLS; 1ST EPISODE; STRESS
AB Stress plays a significant role in schizophrenia from disease onset to exacerbation of psychotic symptoms. Allostatic load (AL) is a measure of cumulative stress to the organism. This study is an extension of our previous work on AL and its relationship to brain structures. Here, we further determined whether elevated AL is a function of illness chronicity, or if it is already present early in the course of schizophrenia. AL was compared in schizophrenia patients early in the illness (within 5 years of disease onset), patients with chronic schizophrenia (more than 5 years of illness), and two groups of healthy controls that were age-and sex-matched to the two patient groups. This work is presented with an expanded sample and includes about two-thirds of the participants who were previously reported. We found that patients with early psychosis had significantly elevated AL score compared with their age-matched controls (rho = 0.005). Chronic course patients also had elevated AL compared with age-matched controls (rho = 0.003). Immune and stress hormone AL subcomponents were nominally higher in early-stage patients compared with controls (rho = 0.005 and 0.04, respectively). Greater AL was also associated with more severe positive psychotic symptoms in early-stage patients (r = 0.54, rho = 0.01). Elevated levels of allostatic load are already present in the early years of the schizophrenia illness, particularly in patients with more severe psychotic symptoms. AL may be a useful evaluation for the need of early intervention on psychosomatic comorbidity.
C1 [Savransky, Anya; Chiappelli, Joshua; Fisseha, Feven; Wisner, Krista M.; Du Xiaoming; Mirmomen, S. Milad; Jones, Aaron D.; Adhikari, Bhim M.; Bruce, Heather A.; Rowland, Laura M.; Hong, L. Elliot] Univ Maryland, Sch Med, Maryland Psychiat Res Ctr, Dept Psychiat, Baltimore, MD 21201 USA.
C3 University System of Maryland; University of Maryland Baltimore
RP Hong, LE (corresponding author), Univ Maryland, Sch Med, Maryland Psychiat Res Ctr, Dept Psychiat, Baltimore, MD 21201 USA.
EM ehong@som.umaryland.edu
RI Rowland, Laura/K-8425-2015; Adhikari, Bhim/K-7390-2019
FU National Institutes of Health [U01MH108148, R01EB015611, P50MH103222,
   R01DA027680, R01MH085646, T32MH067533, U54 EB020403]; State of Maryland
   [M00B6400091]
FX This work was supported by the National Institutes of Health (grant
   numbers U01MH108148, R01EB015611, P50MH103222, R01DA027680, R01MH085646,
   T32MH067533, and U54 EB020403), a State of Maryland contract
   (M00B6400091).
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NR 53
TC 28
Z9 33
U1 0
U2 4
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 2158-3188
J9 TRANSL PSYCHIAT
JI Transl. Psychiatr.
PD NOV 12
PY 2018
VL 8
AR 246
DI 10.1038/s41398-018-0299-z
PG 7
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA HA0TJ
UT WOS:000449921200001
PM 30420620
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Mahmoudi, M
   Charradi, K
   Limam, F
   Aouani, E
AF Mahmoudi, Mohamed
   Charradi, Kamel
   Limam, Ferid
   Aouani, Ezzedine
TI Grape seed and skin extract as an adjunct to xenical therapy reduces
   obesity, brain lipotoxicity and oxidative stress in high fat diet fed
   rats
SO OBESITY RESEARCH & CLINICAL PRACTICE
LA English
DT Article
DE Obesity; Brain; Xenical; Grape seed and skin extract; Oxidative stress
ID CAFETERIA-DIET; PROANTHOCYANIDINS; ORLISTAT; DISEASE; CELLS;
   BIOAVAILABILITY; PURIFICATION; HOMEOSTASIS; LIPOGENESIS; CATECHINS
AB Background: Obesity is a public health problem and a major risk factor for metabolic syndrome. This study was designed to assess the effectiveness of grape seed and skin extract (GSSE) and Xenical (Xe) on high fat diet (HFD)-induced obesity and brain lipotoxicity.& para;& para;Method: Rats were rendered obese and then treated either with vehicle (control) or GSSE (4 g/kg bw) or Xe (1, 2, 4 or 8 mg/kg bw) or (GSSE + Xe) and monitored for weight loss during 3 months. Animals were then sacrificed and their brain utilised for the evaluation of lipotoxicity-induced oxidative stress as well as the putative protection offered by GSSE and Xe treatment.& para;& para;Results: As expected HFD-induced body and adipose tissue weight gain, dyslipidemia, accumulation of lipid into the brain, a drop in adiponectin, increased oxidative stress and disruption of Mn, Ca2+ and of related enzyme activities as glutamine synthetase and calpain. Xe alone exerted anti-obesity effect during the first 2 months and became inefficient thereafter. GSSE per se exhibited potent anti-obesity effect whereas the combination (GSSE + Xe), by acting in concert, was the most efficient against obesity and brain lipotoxicity. GSSE acted partially through its anti-oxidative properties, whereas Xe did not.& para;& para;Conclusion: Combining GSSE with Xe improved outcomes in body weight and fat reduction as well as in brain lipotoxicity. (C) 2016 Asia Oceania Association for the Study of Obesity. Published by Elsevier Ltd. All rights reserved.
C1 [Mahmoudi, Mohamed; Charradi, Kamel; Aouani, Ezzedine] Univ Carthage, Fac Sci Bizerte, Jarzouna 7021, Tunisia.
   [Mahmoudi, Mohamed; Charradi, Kamel; Limam, Ferid; Aouani, Ezzedine] Ctr Biotechnol Borj Cedria, Lab Bioact Subst, BP 901, Hammam Lif 2050, Tunisia.
C3 Universite de Carthage; Centre de Biotechnologie de Borj Cedria
RP Charradi, K (corresponding author), Ctr Biotechnol Borj Cedria, Lab Bioact Subst, BP 901, Hammam Lif 2050, Tunisia.
EM charradi3@yahoo.com
RI Charradi, Kamel/AAR-8778-2021
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NR 46
TC 18
Z9 18
U1 2
U2 21
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1871-403X
EI 1878-0318
J9 OBES RES CLIN PRACT
JI Obes. Res. Clin. Pract.
PD JAN-FEB
PY 2018
VL 12
IS 1
SU 1
BP 115
EP 126
DI 10.1016/j.orcp.2016.04.006
PG 12
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA GB6KC
UT WOS:000429177000013
PM 27161420
DA 2025-06-11
ER

PT J
AU Damasiewicz-Bodzek, A
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AF Damasiewicz-Bodzek, A.
   Wielkoszynski, T.
TI Advanced protein glycation in psoriasis
SO JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
LA English
DT Article
ID GLYCOSYLATION END-PRODUCTS; TERM UREMIC COMPLICATIONS; STRESS MARKER
   LEVELS; OXIDATIVE STRESS; RHEUMATOID-ARTHRITIS; CARBONYL STRESS;
   ATHEROSCLEROTIC LESIONS; LIPID-PEROXIDATION; ALZHEIMERS-DISEASE;
   METABOLIC SYNDROME
AB Background The aetiopathogenesis of psoriasis is very complex and has not been well known. Recently, it has been proposed that mechanisms dependent on free radicals may be involved in the development of this dermatosis. Also, psoriasis coincides with lipid disturbances, diabetes and diseases of cardiovascular system. However, the common mechanism connecting these diseases is still unknown.
   Objectives The aim of this study was to measure concentration of peptides containing glycated residues (AGE-peptides) and IgG, IgA and IgM antibodies against carboxymethyllysine (anti-CML) and carboxyethyllysine (anti-CEL) in the sera of patients at different phases of psoriasis activity in comparison with the sera of healthy individuals.
   Methods The study material consisted of sera from psoriasis patients (n = 80) in active phase and in the remission phase and healthy individuals (n = 80) (controls). Concentrations of AGE-peptides were measured spectrofluorimetrically. Anti-CML and anti-CEL antibody concentrations were determined using ELISA.
   Results In psoriasis patients in active phase disease concentrations of AGE-peptides and anti-CML and anti-CEL antibodies in all tested classes were significantly higher than those in healthy individuals. At remission, concentrations of AGE-peptides and tested antibodies decreased significantly, but concentrations of anti-CEL IgG and anti-CML IgG and IgM antibodies were remaining significantly higher in comparison with the control group.
   Conclusion The obtained results indicate for existence of increased oxidative stress in psoriasis and resulting increased protein glycation and stimulation of the immune system to response to these end-products. Increased protein glyco-oxidation consist a linker between psoriasis and increased prevalence of atherosclerosis, cardiovascular incidents and vascular complications of diabetes.
C1 [Damasiewicz-Bodzek, A.; Wielkoszynski, T.] Med Univ Silesia, Dept Chem, Zabrze, Poland.
C3 Medical University of Silesia
RP Damasiewicz-Bodzek, A (corresponding author), Med Univ Silesia, Dept Chem, Zabrze, Poland.
EM olabodzek@interia.pl
OI Wielkoszynski, Tomasz/0000-0002-8823-3313
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NR 64
TC 26
Z9 26
U1 0
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0926-9959
EI 1468-3083
J9 J EUR ACAD DERMATOL
JI J. Eur. Acad. Dermatol. Venereol.
PD FEB
PY 2012
VL 26
IS 2
BP 172
EP 179
DI 10.1111/j.1468-3083.2011.04024.x
PG 8
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 882GK
UT WOS:000299551600006
PM 21395695
DA 2025-06-11
ER

PT J
AU Rankin, JW
   Andreae, MC
   Chen, CYO
   O'Keefe, SF
AF Rankin, J. W.
   Andreae, M. C.
   Chen, C. -Y. Oliver
   O'Keefe, S. F.
TI Effect of raisin consumption on oxidative stress and inflammation in
   obesity
SO DIABETES OBESITY & METABOLISM
LA English
DT Article
DE antioxidants; cytokines; endothelial activation; ORAC; postprandial
   response
ID PLASMA ANTIOXIDANT CAPACITY; C-REACTIVE PROTEIN; HIGH-FAT MEAL;
   ENDOTHELIAL DYSFUNCTION; CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME;
   HEALTHY; SUPPLEMENTATION; INCREASES; WOMEN
AB Aim: Oxidative stress can initiate increased inflammation that elevates risk for cardiovascular disease. The objective of this study was to determine the effects of daily consumption of raisins on markers of oxidative stress, inflammation and endothelial activation in response to an acute high-fat meal in overweight individuals.
   Methods: Seventeen overweight men and women consumed 90 g raisins or isocaloric placebo ( 264 kcal/day) for 14 days in a randomized, crossover design while following a low-flavonoid diet. The oxidative [urinary 8-isoprostaglandin-F-2 alpha (8-epi PGF(2 alpha)) and serum oxygen radical absorbance capacity (ORAC)], inflammatory (serum C-reactive protein and interleukin-6), endothelial ( serum soluble intercellular adhesion molecule-1 and soluble vascular cell adhesion molecule-1, sVCAM-1) and metabolic [ free fatty acids (FFAs), triacylglycerol, glucose and insulin] response to four high-fat (53%) meals was tested pre- and postintervention.
   Results: Urinary 8-epi PGF(2 alpha) decreased (-22%) and fasting ORAC increased (+3%) after both interventions combined. Fasting protein-free ORAC was modestly (+3.5%) higher during the raisin than the placebo intervention. Neither the meals nor the raisins consistently induced fasted markers of inflammation or endothelial dysfunction. Gender influenced postprandial metabolic responses in that males responded with higher serum FFAs, sVCAM-1 and glucose compared with females.
   Conclusions: Serum antioxidant capacity was modestly increased by daily raisin consumption, but this did not alter fasted or postprandial inflammatory response in these relatively healthy but overweight individuals. Providing all food in regular pattern reduced measures of oxidative stress.
C1 [Rankin, J. W.; Andreae, M. C.] Virginia Tech, Dept Human Nutr Foods & Exercise, Blacksburg, VA 24061 USA.
   [Chen, C. -Y. Oliver] Tufts Univ, Jean Mayer USDA Human Nutr Res Ctr Aging, Boston, MA 02111 USA.
   [O'Keefe, S. F.] Virginia Tech, Dept Food Sci & Technol, Blacksburg, VA USA.
C3 Virginia Polytechnic Institute & State University; Tufts University;
   United States Department of Agriculture (USDA); Virginia Polytechnic
   Institute & State University
RP Rankin, JW (corresponding author), Virginia Tech, Dept Human Nutr Foods & Exercise, Blacksburg, VA 24061 USA.
EM jrankin@vt.edu
RI Chen, Yung-Chung/GRY-3101-2022; OKeefe, Sean/N-3101-2016
FU California Raisin Marketing Board
FX This study was funded by the California Raisin Marketing Board. We
   appreciate the assistance and advice of Dr Brenda Davy with diet
   analysis and Janet Rinehart for technical assistance.
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NR 40
TC 51
Z9 55
U1 0
U2 15
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1462-8902
EI 1463-1326
J9 DIABETES OBES METAB
JI Diabetes Obes. Metab.
PD NOV
PY 2008
VL 10
IS 11
BP 1086
EP 1096
DI 10.1111/j.1463-1326.2008.00867.x
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 361GD
UT WOS:000260114600012
PM 18355330
DA 2025-06-11
ER

PT J
AU Apaijai, N
   Pintana, H
   Saengmearnuparp, T
   Kongkaew, A
   Arunsak, B
   Chunchai, T
   Chattipakorn, SC
   Chattipakorn, N
AF Apaijai, Nattayaporn
   Pintana, Hiranya
   Saengmearnuparp, Thiraphat
   Kongkaew, Apisek
   Arunsak, Busarin
   Chunchai, Titikorn
   Chattipakorn, Siriporn C.
   Chattipakorn, Nipon
TI Inhibition of 5-alpha reductase attenuates cardiac oxidative damage in
   obese and aging male rats via the enhancement of antioxidants and the
   p53 protein suppression
SO CHEMICO-BIOLOGICAL INTERACTIONS
LA English
DT Article
DE D -galactose; High-fat diet; Metabolic function; Cardiac function; p53
ID BENIGN PROSTATIC HYPERPLASIA; FINASTERIDE; HEART; HYPERTROPHY; DISEASE
AB In aging and metabolic syndrome oxidative stress is a causative factor in the cardiovascular pathology. Upregulation of 5-alpha reductase is associated with cardiac hypertrophy but how inhibition of 5-alpha reductase affects cardiometabolic function during oxidative damage under those conditions is unclear. Our hypothesis was that Finasteride (Fin), a 5-alpha reductase inhibitor, promotes an antioxidant response, leading to an improvement in cardiac function in obese and aging rats. Male rats were divided into 3 groups including normal diet (ND) fed rats, ND-fed rats treated with D-galactose (D-gal) to induce aging, and high-fat diet (HFD) fed rats to induce obesity. Rats received their assigned diet or D-gal for 18 weeks. At week 13, rats in each group were divided into 2 subgroups and received either a vehicle or Fin (5 mg/kg/day, oral gavage). Cardiometabolic and molecular parameters were subsequently investigated. Both D-gal and HFD successfully induced cardiometabolic dysfunction, oxidative stress, mitochondrial dysfunction, and DNA fragmentation. Fin treatment did not affect metabolic disturbances; however, it reduced cardiac sympathovagal imbalance, cardiac dysfunction through the inhibition of oxidative stress and promoted antioxidants, resulting in reduced p53 protein levels and DNA fragmentation. Surprisingly, Fin induced insulin resistance in ND-fed rats. Fin effectively improved cardiac function in both models by enhancing antioxidant levels, suppressing oxidative stress and DNA fragmentation. However, Fin treatment did not confer any beneficial effects on metabolic status. Fin administration effectively improved cardiac sympathovagal balance and cardiac function in rats with oxidative damage induced by either D-gal or HFD.
C1 [Apaijai, Nattayaporn; Pintana, Hiranya; Saengmearnuparp, Thiraphat; Arunsak, Busarin; Chunchai, Titikorn; Chattipakorn, Siriporn C.; Chattipakorn, Nipon] Chiang Mai Univ, Fac Med, Cardiac Electrophysiol Res & Training Ctr, Chiang Mai 50200, Thailand.
   [Apaijai, Nattayaporn; Pintana, Hiranya; Saengmearnuparp, Thiraphat; Arunsak, Busarin; Chunchai, Titikorn; Chattipakorn, Siriporn C.; Chattipakorn, Nipon] Chiang Mai Univ, Ctr Excellence Cardiac Electrophysiol Res, Chiang Mai 50200, Thailand.
   [Apaijai, Nattayaporn; Chattipakorn, Nipon] Chiang Mai Univ, Fac Med, Dept Physiol, Cardiac Electrophysiol Unit, Chiang Mai 50200, Thailand.
   [Saengmearnuparp, Thiraphat] Chiang Mai Univ, Fac Med, Dept Surg, Div Urol, Chiang Mai 50200, Thailand.
   [Kongkaew, Apisek] Chiang Mai Univ, Fac Med, Res Adm Sect, Chiang Mai 50200, Thailand.
   [Chattipakorn, Siriporn C.] Chiang Mai Univ, Fac Dent, Dept Oral Biol & Diagnost Sci, Chiang Mai 50200, Thailand.
   [Chattipakorn, Nipon] Acad Sci, Royal Soc Thailand, Bangkok, Thailand.
C3 Chiang Mai University; Chiang Mai University; Chiang Mai University;
   Chiang Mai University; Chiang Mai University; Chiang Mai University
RP Chattipakorn, N (corresponding author), Chiang Mai Univ, Fac Med, Cardiac Electrophysiol Res & Training Ctr, Chiang Mai 50200, Thailand.
EM nchattip@gmail.com
RI Saengmearnuparp, Thiraphat/ABC-9476-2022; Chattipakorn,
   Nipon/AAJ-4049-2021
OI Chattipakorn, Siriporn/0000-0003-1677-7052; Chattipakorn,
   Nipon/0000-0003-3026-718X
FU Distinguished Research Professor from the National Research Council of
   Thailand [N42A660301]; National Research Council of Thailand Research
   Chair Grant; National Research Council of Thailand [N42A660432,
   N42A650207]; Thailand Science Research and Innovation-Chiang Mai
   University (Fundamental Fund) [2566]; Chiang Mai University Center of
   Excellence Award
FX This work was supported by Distinguished Research Professor from the
   National Research Council of Thailand (N42A660301to SCC) , the National
   Research Council of Thailand Research Chair Grant (NC) , the National
   Research Council of Thailand (N42A660432 to NA, N42A650207 to HP) ,
   Thailand Science Research and Innovation-Chiang Mai University
   (Fundamental Fund 2566 to NA) , and the Chiang Mai University Center of
   Excellence Award (NC) .
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NR 44
TC 1
Z9 1
U1 2
U2 4
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0009-2797
EI 1872-7786
J9 CHEM-BIOL INTERACT
JI Chem.-Biol. Interact.
PD NOV 1
PY 2024
VL 403
AR 111240
DI 10.1016/j.cbi.2024.111240
EA SEP 2024
PG 9
WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology
GA Q7M8F
UT WOS:001386480900001
PM 39265715
DA 2025-06-11
ER

PT J
AU Lee, DY
   Bahar, ME
   Kim, CW
   Seo, MS
   Song, MG
   Song, SY
   Kim, SY
   Kim, DR
   Kim, DH
AF Lee, Dong-Yeong
   Bahar, Md Entaz
   Kim, Chang-Won
   Seo, Min-Seok
   Song, Myung-Geun
   Song, Sang-Youn
   Kim, Soung-Yon
   Kim, Deok-Ryong
   Kim, Dong-Hee
TI Autophagy in Osteoarthritis: A Double-Edged Sword in Cartilage Aging and
   Mechanical Stress Response: A Systematic Review
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Review
DE chondrocyte; cartilage; arthritis; osteoarthritis; autophagy
ID SATURATED FATTY-ACIDS; METABOLIC SYNDROME; CELL-DEATH; CHONDROCYTE
   DEATH; OXIDATIVE STRESS; PATHOGENESIS; INFLAMMATION; APOPTOSIS;
   MITOCHONDRIA; SUPPRESSES
AB Background: Although osteoarthritis (OA) development is epidemiologically multifactorial, a primary underlying mechanism is still under debate. Understanding the pathophysiology of OA remains challenging. Recently, experts have focused on autophagy as a contributor to OA development. Method: To better understand the pathogenesis of OA, we survey the literature on the role of autophagy and the molecular mechanisms of OA development. To identify relevant studies, we used controlled vocabulary and free text keywords to search the MEDLINE, EMBASE, the Cochrane Central Register of Controlled Trials, Web of Science, and SCOPUS database. Thirty-one studies were included for data extraction and systematic review. Among these studies, twenty-five studies investigated the effects of autophagy in aging and OA chondrocytes, six studies examined the effects of autophagy in normal human chondrocytes, and only one study investigated the effects of mechanical stress-induced autophagy on the development of OA in normal chondrocytes. Results: The studies suggest that autophagy activation prevents OA by exerting cell-protective effects in normal human chondrocytes. However, in aging and osteoarthritis (OA) chondrocytes, the role of autophagy is intricate, as certain studies indicate that stimulating autophagy in these cells can have a cytotoxic effect, while others propose that it may have a protective (cytoprotective) effect against damage or degeneration. Conclusions: Mechanical stress-induced autophagy is also thought to be involved in the development of OA, but further research is required to identify the precise mechanism. Thus, autophagy contributions should be interpreted with caution in aging and the types of OA cartilage.
C1 [Lee, Dong-Yeong] Barun Hosp, Dept Orthopaed Surg, Jinju 52725, South Korea.
   [Bahar, Md Entaz; Seo, Min-Seok; Kim, Deok-Ryong] Gyeongsang Natl Univ, Inst Hlth Sci, Coll Med, Dept Biochem & Convergence Med Sci, Jinju 52727, South Korea.
   [Kim, Chang-Won; Song, Sang-Youn; Kim, Soung-Yon; Kim, Dong-Hee] Gyeongsang Natl Univ Hosp, Inst Med Sci, Dept Orthopaed Surg, Jinju 52727, South Korea.
   [Song, Myung-Geun] Inha Univ Hosp, Dept Orthopaed Surg, Incheon 22212, South Korea.
C3 Gyeongsang National University; Gyeongsang National University;
   Gyeongsang National University Hospital; Inha University; Inha
   University Hospital
RP Kim, DR (corresponding author), Gyeongsang Natl Univ, Inst Hlth Sci, Coll Med, Dept Biochem & Convergence Med Sci, Jinju 52727, South Korea.; Kim, DH (corresponding author), Gyeongsang Natl Univ Hosp, Inst Med Sci, Dept Orthopaed Surg, Jinju 52727, South Korea.
EM whatttary@hanmail.net; entazbahar@gnu.ac.kr; kcw_blue@naver.com;
   majestyno1@naver.com; piano10000@naver.com; songsangyoun@gmail.com;
   soungyon.kim@gmail.com; drkim@gnu.ac.kr; dhkim8311@gnu.ac.kr
RI Lee, Da Young/AAA-1843-2021; Kim, Deok Ryong/LTF-4760-2024
OI Kim, Deok Ryong/0000-0002-3288-8257; Kim, Dong-Hee/0000-0001-6378-4218
FU Ministry of Education
FX No Statement Available
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NR 82
TC 5
Z9 5
U1 5
U2 8
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD MAY
PY 2024
VL 13
IS 10
AR 3005
DI 10.3390/jcm13103005
PG 16
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA SE5W6
UT WOS:001232805200001
PM 38792546
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Xue, SY
   Han, HD
   Rui, SL
   Yang, ML
   Huang, YZ
   Zhan, B
   Geng, S
   Liu, H
   Chen, C
   Yang, GY
   Li, L
AF Xue, Shiyao
   Han, Hongdong
   Rui, Shunli
   Yang, Mengliu
   Huang, Yizhou
   Zhan, Bin
   Geng, Shan
   Liu, Hua
   Chen, Chen
   Yang, Gangyi
   Li, Ling
TI Serum Fetuin-B Levels Are Elevated in Women with Metabolic Syndrome and
   Associated with Increased Oxidative Stress
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Article
ID INSULIN-RESISTANCE; CARDIOVASCULAR-DISEASE; HEPATIC STEATOSIS;
   ADIPOSE-TISSUE; RISK; MANAGEMENT; IMPACT; OBESE
AB Previous studies on serum fetuin-B (fetuin-like protein IRL685) have investigated its association with T2DM; however, the reason for the variation in serum fetuin-B and its regulatory factors in metabolic disease remain unclear. Here, we evaluated serum fetuin-B levels in women with newly diagnosed MetS and performed multiple interventions to investigate the role of fetuin-B in the pathogenesis of MetS. Serum fetuin-B levels were assessed using ELISA. Bioinformatics analysis was performed to analyze fetuin-B-related genes and signaling pathways. Additionally, oxidative stress parameters were measured in the in vitro study. For subgroup analyses, we performed EHC, OGTT, and treatment with a GLP-1RA to investigate the regulatory factors of serum fetuin-B. We found that in comparison with healthy subjects, serum fetuin-B levels were markedly increased in women with MetS. Further, serum fetuin-B showed a positive correlation with WHR, FAT%, TG, FBG, HbA1c, Fins, HOMA-IR, VAI, and LAP. Bioinformatics analysis revealed that most fetuin-B-related core genes were involved in cholesterol metabolism and fat decomposition. Consistent with this finding, multivariate regression analysis showed that triglyceride content and WHR were independently associated with serum fetuin-B. We also observed that serum fetuin-B levels were markedly elevated in healthy subjects after glucose loading and in women with MetS during EHC. In vitro, overexpression of fetuin-B promoted oxidative stress in HepG2 cell. After 6 months of treatment with a GLP-1RA, serum fetuin-B levels in women with MetS decreased following an improvement in metabolism and insulin sensitivity. Therefore, serum fetuin-B is associated with MetS, which may serve as a biomarker of oxidative stress.
C1 [Xue, Shiyao; Rui, Shunli; Li, Ling] Chongqing Med Univ, Coll Lab Med, Key Lab Diagnost Med, Minist Educ, Chongqing 400016, Peoples R China.
   [Xue, Shiyao; Rui, Shunli; Li, Ling] Chongqing Med Univ, Coll Lab Med, Dept Clin Biochem, Chongqing 400016, Peoples R China.
   [Xue, Shiyao; Han, Hongdong; Yang, Mengliu; Huang, Yizhou; Geng, Shan; Yang, Gangyi] Chongqing Med Univ, Affiliated Hosp 2, Dept Endocrinol, Chongqing 400010, Peoples R China.
   [Rui, Shunli] Chongqing Univ, Chongqing Univ Cent Hosp, Chongqing Emergency Med Ctr Chongqing, Dept Endocrinol Multidisciplinary Diabet Foot Med, Chongqing, Peoples R China.
   [Yang, Mengliu; Chen, Chen] Univ Queensland, Fac Med, SBMS, Endocrinol, Brisbane, Qld 4072, Australia.
   [Zhan, Bin] Thirteenth Peoples Hosp Chongqing, Chongqing 400016, Peoples R China.
   [Liu, Hua] Univ Mississippi, Dept Pediat, Med Ctr, 2500 North State St, Jackson, MS 39216 USA.
C3 Ministry of Education - China; Chongqing Medical University; Chongqing
   Medical University; Chongqing Medical University; Chongqing University;
   University of Queensland; University of Mississippi Medical Center;
   University of Mississippi
RP Li, L (corresponding author), Chongqing Med Univ, Coll Lab Med, Key Lab Diagnost Med, Minist Educ, Chongqing 400016, Peoples R China.; Li, L (corresponding author), Chongqing Med Univ, Coll Lab Med, Dept Clin Biochem, Chongqing 400016, Peoples R China.
EM liling@cqmu.edu.cn
RI LIU, YULU/C-4121-2018; huang, yizhou/KPA-7194-2024; Chen,
   Chen/B-4284-2010
OI Yang, Mengliu/0000-0003-1896-0002; Geng, Shan/0000-0003-0838-4726; Li,
   Ling/0000-0002-0087-3034; Xue, Shiyao/0000-0001-6459-8871; Chen,
   Chen/0000-0003-2104-534X
FU National Natural Science Foundation of China [81300670]; Science and
   Technology Program of Health Bureau of Chongqing [2019ZDXM039]
FX This work was supported by research grants from the National Natural
   Science Foundation of China (81300670) and from the Science and
   Technology Program of Health Bureau of Chongqing (2019ZDXM039). We thank
   patients and healthy individuals who made this study possible.
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NR 41
TC 5
Z9 5
U1 0
U2 8
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PD OCT 4
PY 2021
VL 2021
AR 6657658
DI 10.1155/2021/6657658
PG 17
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA YZ4MI
UT WOS:000755451000001
PM 34646426
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Reddy, MRG
   Jeyakumar, SM
   Vajreswari, A
AF Reddy, Mooli Raja Gopal
   Jeyakumar, Shanmugam Murugaiha
   Vajreswari, Ayyalasomayajula
TI Consumption of vitamin A-deficient diet elevates endoplasmic reticulum
   stress marker and suppresses high fructose-induced orexigenic gene
   expression in the brain of male Wistar rats
SO NUTRITIONAL NEUROSCIENCE
LA English
DT Article
DE Lipids; fatty acid; diet; energy homeostasis; cognition; metabolic
   syndrome; DHA; neurodegeneration
AB Vitamin A deficiency and excessive fructose consumption are known to cause functional impairment of various vital organs including the brain in the mammalian system. However, the underlying pathways and molecular mechanisms are not fully understood.
   Objective: Here, we assessed the impact of vitamin A deficiency (both alone and in combination with fructose) on the retinol status, phospholipids fatty acid composition and pathways associated with the endoplasmic reticulum (ER) stress and energy homeostasis of the brain. For this purpose, weanling male Wistar rats were divided into four groups consisting of 8 rats each, except 16 for the second group and they received one of the following diets; control, vitamin A-deficient (VAD), high fructose (HFr) and HFr with VAD for 16 weeks, except half of the VAD diet-fed rats, were shifted to HFr diet, after 8 weeks period.
   Results: The retinol content of the whole brain remained comparable across the groups, despite a significant reduction in the plasma at the end of VAD diet feeding. However, it suppressed the HFr-induced neuropeptide Y and agouti-related peptide, while rescuing the leptin receptor mRNA. Among ER stress markers, CCAAT/Enhancer-binding protein homologues protein levels were elevated significantly in the VAD diet-fed group. Further, the long-chain polyunsaturated fatty acid levels showed an increase in the brain phospholipids across the experimental groups, compared to that of the control.
   Conclusion: Vitamin A deficiency causes ER stress in the brain, and retinol seems to play a regulatory role in the fructose-mediated transcriptional regulation of the genes involved in energy homeostasis.
C1 [Reddy, Mooli Raja Gopal; Jeyakumar, Shanmugam Murugaiha; Vajreswari, Ayyalasomayajula] ICMR Natl Inst Nutr, Lipid Biochem Div, Hyderabad 500007, Telangana, India.
   [Jeyakumar, Shanmugam Murugaiha] ICMR Natl Inst Res TB, Clin Pharmacol Div, 1 Sathiyamoorthy Rd, Chennai 600031, Tamil Nadu, India.
C3 Indian Council of Medical Research (ICMR); ICMR - National Institute of
   Nutrition (NIN); Indian Council of Medical Research (ICMR); ICMR -
   National Institute for Research in Tuberculosis (NIRT)
RP Jeyakumar, SM (corresponding author), ICMR Natl Inst Nutr, Lipid Biochem Div, Hyderabad 500007, Telangana, India.
EM smjkumar@gmail.com
RI Reddy, Raja Gopal/IWU-8572-2023; Mooli, Raja Gopal Reddy/T-6215-2018
OI Mooli, Raja Gopal Reddy/0000-0003-4176-5352
FU Indian Council of Medical Research (ICMR) [5/4/3-10/TF/2011/NCD-II]
FX This work was supported by Indian Council of Medical Research (ICMR) &
   Grant Ref no. 5/4/3-10/TF/2011/NCD-II.
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NR 43
TC 5
Z9 5
U1 0
U2 4
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1028-415X
EI 1476-8305
J9 NUTR NEUROSCI
JI Nutr. Neurosci.
PD SEP 2
PY 2022
VL 25
IS 9
BP 1872
EP 1880
DI 10.1080/1028415X.2021.1911048
EA APR 2021
PG 9
WC Neurosciences; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Nutrition & Dietetics
GA 4P2AA
UT WOS:000638260200001
PM 33827391
DA 2025-06-11
ER

PT J
AU Adebayo, AA
   Oboh, G
   Ademosun, AO
AF Adebayo, Adeniyi A.
   Oboh, Ganiyu
   Ademosun, Ayokunle O.
TI Effect of dietary inclusion of almond fruit on sexual behavior, arginase
   activity, pro-inflammatory, and oxidative stress markers in diabetic
   male rats
SO JOURNAL OF FOOD BIOCHEMISTRY
LA English
DT Article
DE almond drupe and seed; arginase activity; erectile dysfunction; NF-kappa
   B; TNF-alpha
ID NF-KAPPA-B; PROTEIN-KINASE-C; NITRIC-OXIDE; ERECTILE DYSFUNCTION;
   ENDOTHELIAL-CELLS; ELLAGIC ACID; INHIBITION; FLAVONOIDS; QUERCETIN;
   PHOSPHORYLATION
AB This study was designed to examine the effect of almond-included diets on sexual behavior, arginase activity, and pro-inflammatory markers in diabetic male rats. Forty-two male rats were divided into seven groups (n = 6). Diabetes was triggered via a single dose intraperitoneal injection of streptozotocin (50 mg/kg). Diabetes was confirmed 72 hr after STZ induction, and animals with blood glucose >= 250 mg/dl were considered diabetic and used for the experiment. The effects of almond-supplemented diets on glucose level, sexual function, NF-kappa B and TNF-alpha levels, arginase and purinergic enzyme activities, and levels of oxidative stress markers were assessed. A significant decrease in sexual activities with a simultaneous increase in pro-inflammatory markers, arginase and purinergic enzyme activities as well as TBARS and ROS levels was observed in diabetic rats. Interestingly, treatment with supplemented diets ameliorated the effects. Conclusively, intake of almonds could prevent the risk of erectile dysfunction in diabetic subjects.
   Practical applications Intake of diets rich in fruits, nuts, and vegetables has been reported to reduce the risk of metabolic syndrome. Here, we investigate the effect of dietary inclusion of almond fruit on sexual behavior, arginase activity, oxidative stress, and pro-inflammatory markers in diabetic male rats. Interestingly, data generated from this work reveal that the supplemented diets enhanced sexual activities, and reduced oxidative stress and pro-inflammatory markers in diabetic male rats. Thus, consumption of almond (drupe and seed) could prevent/reduce the erectile dysfunction in individual with diabetes.
C1 [Adebayo, Adeniyi A.; Oboh, Ganiyu; Ademosun, Ayokunle O.] Fed Univ Technol Akure, Biochem Dept, PMB 704, Akure 340001, Nigeria.
   [Adebayo, Adeniyi A.] Joseph Ayo Babalola Univ, Chem Sci Dept, Biochem Unit, Ikeji Arakeji, Nigeria.
RP Adebayo, AA; Oboh, G (corresponding author), Fed Univ Technol Akure, Biochem Dept, PMB 704, Akure 340001, Nigeria.
EM adeniyiabiodun2@gmail.com; goboh@futa.edu.ng
RI Ademosun, Ayokunle/O-4299-2019; Oboh, Ganiyu/AAW-5664-2020; Adebayo,
   Adeniyi/AAW-7178-2020
OI Adebayo, Adeniyi/0000-0002-7428-0119; Oboh, Ganiyu/0000-0001-5167-9779;
   Ademosun, Ayokunle/0000-0001-9767-1844
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NR 67
TC 12
Z9 13
U1 0
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0145-8884
EI 1745-4514
J9 J FOOD BIOCHEM
JI J. Food Biochem.
PD MAR
PY 2021
VL 45
IS 3
AR e13269
DI 10.1111/jfbc.13269
EA MAY 2020
PG 12
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA RF6JC
UT WOS:000531684500001
PM 32394504
OA gold
DA 2025-06-11
ER

PT J
AU Shen, SS
   Yang, L
   Li, LN
   Bai, Y
   Liu, HW
AF Shen, Sensen
   Yang, Li
   Li, Linnan
   Bai, Yu
   Liu, Huwei
TI Lipid metabolism in mouse embryonic fibroblast cells in response to
   autophagy induced by nutrient stress
SO ANALYTICA CHIMICA ACTA
LA English
DT Article
DE Mouse embryonic fibroblast cells; Acute starvation; Autophagy;
   Lipidomics; 2D LC-QToF-MS
ID FLIGHT MASS-SPECTROMETRY; LC-QTOF-MS; HUMAN PLASMA; STARVATION; DISEASE;
   MICE; PROTEINS; BREAST; GLYCEROPHOSPHOLIPIDS; SPHINGOLIPIDS
AB Autophagy is of great significance in maintaining cellular homeostasis. Aberrant autophagy has been reported to contribute to the disease aetiology of metabolic syndrome, especially several key lysosomal storage disorders. However, the molecular mechanisms and the correlation between autophagy and lipid metabolism remains unclear. This study was designed and aimed to reveal the alteration of lipid metabolism in response to the autophagy induced by nutrient stress to give new insights into the molecular mechanisms between autophagy and lipid metabolism. An online normal-phase/reversed-phase two-dimensional liquid chromatography-mass spectrometry (NP/RP 2D LC-MS) method was developed to perform the lipidomics analysis of Atg7(-/-) mouse embryonic fibroblast cells (MEFs) and wild-type MEFs under nutrient stress. 48 and 35 lipid species in wild-type and Atg7(-/-) MEFs respectively finally meet the screening criteria with p-value less than 0.05 and fold change more than 1.5 in response to nutrient stress. Their alterations indicated that autophagy participated lipid metabolism to generate energy and form autophagosomes with significantly increased free fatty acids and glycerophospholipids, which protected wild-type MEFs from serious damages and delayed cell death. However, in Atg7(-/-) MEFs, due to the inhibition of autophagy, lipids were continuously consumed and cells suffered from damages even death. These results illustrated the close relationship between autophagy and lipid metabolism comprehensively and revealed diverse lipid targets for the investigation of autophagy. (c) 2017 Elsevier B.V. All rights reserved.
C1 [Shen, Sensen; Yang, Li; Li, Linnan; Bai, Yu; Liu, Huwei] Peking Univ, Beijing Natl Lab Mol Sci, Inst Analyt Chem,Minist Educ, Coll Chem & Mol Engn,Key Lab Bioorgan Chem & Mol, Beijing 100871, Peoples R China.
C3 Ministry of Education - China; Peking University; Chinese Academy of
   Sciences
RP Bai, Y (corresponding author), Peking Univ, Beijing Natl Lab Mol Sci, Inst Analyt Chem,Minist Educ, Coll Chem & Mol Engn,Key Lab Bioorgan Chem & Mol, Beijing 100871, Peoples R China.
EM yu.bai@pku.edu.cn
RI Li, Linnan/W-4768-2019; Bai, Yu/AFV-2004-2022
OI Bai, Yu/0000-0003-1542-0297; Shen, Sensen/0000-0002-0479-603X; Li,
   Linnan/0000-0001-7394-8095
FU National Natural Science Foundation of China [21322505, 21527809]
FX We thank Prof. Li Yu for providing the MEF cells. This research is
   supported by the National Natural Science Foundation of China (Nos.
   21322505 and 21527809).
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NR 42
TC 11
Z9 12
U1 0
U2 93
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0003-2670
EI 1873-4324
J9 ANAL CHIM ACTA
JI Anal. Chim. Acta
PD DEC 11
PY 2018
VL 1037
SI SI
BP 75
EP 86
DI 10.1016/j.aca.2017.11.005
PG 12
WC Chemistry, Analytical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry
GA GV6MH
UT WOS:000446225000008
PM 30292317
DA 2025-06-11
ER

PT J
AU Rangel-Zuñiga, OA
   Haro, C
   Tormos, C
   Perez-Martinez, P
   Delgado-Lista, J
   Marin, C
   Quintana-Navarro, GM
   Cerdá, C
   Sáez, GT
   Lopez-Segura, F
   Lopez-Miranda, J
   Perez-Jimenez, F
   Camargo, A
AF Rangel-Zuniga, Oriol A.
   Haro, Carmen
   Tormos, Carmen
   Perez-Martinez, Pablo
   Delgado-Lista, Javier
   Marin, Carmen
   Quintana-Navarro, Gracia M.
   Cerda, Concha
   Saez, Guillermo T.
   Lopez-Segura, Fernando
   Lopez-Miranda, Jose
   Perez-Jimenez, Francisco
   Camargo, Antonio
TI Frying oils with high natural or added antioxidants content, which
   protect against postprandial oxidative stress, also protect against DNA
   oxidation damage
SO EUROPEAN JOURNAL OF NUTRITION
LA English
DT Article
DE Frying oils; Virgin olive oil; Oxidative stress; DNA oxidation damage;
   Phenolic compounds
ID BASE EXCISION-REPAIR; METABOLIC SYNDROME; P53; ACTIVATION; PATHWAY;
   OLIVE; FAT; CARCINOGENESIS; HYPERTENSION; RECOGNITION
AB Using sunflower oil as frying oil increases postprandial oxidative stress, which is considered the main endogenous source of DNA oxidative damage. We aimed to test whether the protective effect of virgin olive oil and oil models with added antioxidants against postprandial oxidative stress may also protect against DNA oxidative damage.
   Twenty obese people received four breakfasts following a randomized crossover design consisting of different oils [virgin olive oil (VOO), sunflower oil (SFO), and a mixed seed oil (SFO/canola oil) with added dimethylpolysiloxane (SOX) or natural antioxidants from olives (SOP)], which were subjected to 20 heating cycles.
   We observed the postprandial increase in the mRNA levels of p53, OGG1, POLB, and GADD45b after the intake of the breakfast prepared with SFO and SOX, and an increase in the expression of MDM2, APEX1, and XPC after the intake of the breakfast prepared with SFO, whereas no significant changes at the postprandial state were observed after the intake of the other breakfasts (all p values < 0.05). We observed lower 8-OHdG postprandial levels after the intake of the breakfast prepared with VOO and SOP than after the intake of the breakfast prepared with SFO and SOX (all p values < 0.05).
   Our results support the beneficial effect on DNA oxidation damage of virgin olive oil and the oil models with added antioxidants, as compared to the detrimental use of sunflower oil, which induces p53-dependent DNA repair pathway activation.
C1 [Rangel-Zuniga, Oriol A.; Haro, Carmen; Perez-Martinez, Pablo; Delgado-Lista, Javier; Marin, Carmen; Quintana-Navarro, Gracia M.; Lopez-Segura, Fernando; Lopez-Miranda, Jose; Perez-Jimenez, Francisco; Camargo, Antonio] Univ Cordoba, Lipids & Atherosclerosis Unit, IMIBIC, Reina Sofia Univ Hosp, Ave Menendez Pidal S-N, E-14004 Cordoba, Spain.
   [Rangel-Zuniga, Oriol A.; Haro, Carmen; Tormos, Carmen; Perez-Martinez, Pablo; Delgado-Lista, Javier; Marin, Carmen; Quintana-Navarro, Gracia M.; Cerda, Concha; Saez, Guillermo T.; Lopez-Segura, Fernando; Lopez-Miranda, Jose; Perez-Jimenez, Francisco; Camargo, Antonio] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr CIBEROBN, Madrid, Spain.
   [Tormos, Carmen; Cerda, Concha] Univ Valencia, Gen Univ Hosp, Dept Biochem & Mol Biol, Serv Clin Anal,CDB, Valencia, Spain.
   [Saez, Guillermo T.] Univ Valencia, Univ Hosp Doctor PESET, Sch Med, Dept Biochem & Mol Biol,Serv Clin Anal,INCLIVA, Valencia, Spain.
C3 Universidad de Cordoba; CIBER - Centro de Investigacion Biomedica en
   Red; CIBEROBN; Instituto de Salud Carlos III; University of Valencia;
   University of Valencia
RP Camargo, A (corresponding author), Univ Cordoba, Lipids & Atherosclerosis Unit, IMIBIC, Reina Sofia Univ Hosp, Ave Menendez Pidal S-N, E-14004 Cordoba, Spain.; Camargo, A (corresponding author), Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr CIBEROBN, Madrid, Spain.
EM b92cagaa@uco.es
RI Jimenez, Francisco/AAJ-9559-2021; Lopez-Miranda, Jose/Y-8306-2019;
   Delgado-Lista, Javier/KAM-7412-2024; Marin Hinojosa,
   Carmen/AFO-1294-2022; Camargo Garcia, Antonio/G-9720-2015; HARO,
   CARMEN/P-3104-2016; Perez Martinez, Pablo/AEL-6176-2022
OI Lopez-Miranda, Jose/0000-0002-8844-0718; Rangel-Zuniga, Oriol
   Alberto/0000-0003-3495-5705; Camargo Garcia,
   Antonio/0000-0002-0415-4184; HARO, CARMEN/0000-0002-1355-8359;
   QUINTANA-NAVARRO, GRACIA MARIA/0000-0003-4413-4062; Perez Martinez,
   Pablo/0000-0001-7716-8117; Delgado Lista, Francisco
   Javier/0000-0002-2982-2716; Saez, Guillermo/0000-0002-8164-4048
FU Spanish Ministry of Science and Innovation [AGL 2004-07907, AGL
   2006-01979, AGL 2009-12270, SAF07-62005, FIS PI10/01041, PI10/02412,
   PI13/00619]; Consejeria de Economia, Innovacion y Ciencia, Proyectos de
   Investigacion de Excelencia, Junta de Andalucia [P06-CTS-01425, CTS5015
   and AGR922]; Consejeria de Salud, Junta de Andalucia [06/128, 07/43,
   PI0193/09, 06/129, 06/127, PI-0252/09, PI-0058/10]; Fondo Europeo de
   Desarrollo Regional (FEDER); ISCIII research contract (Programa
   Miguel-Servet) [CP14/00114];  [PI/13/01848];  [GVA-ACOM2012/238]; 
   [PI10/OO802/CB12/03/30016]
FX The CIBEROBN is an initiative of the Instituto de Salud Carlos III,
   Madrid, Spain. This study supported in part by research grants from the
   Spanish Ministry of Science and Innovation (AGL 2004-07907, AGL
   2006-01979, and AGL 2009-12270 to J. L.-M., SAF07-62005 to E P.-J. and
   FIS PI10/01041 to P. P.-M., PI10/02412 and PI13/00619 to F. P.-J.);
   Consejeria de Economia, Innovacion y Ciencia, Proyectos de Investigacion
   de Excelencia, Junta de Andalucia (P06-CTS-01425 to J. L.-M., CTS5015
   and AGR922 to F. P.-J.); Consejeria de Salud, Junta de Andalucia
   (06/128, 07/43, and PI0193/09 to J. L.-M, 06/129 to F. P.-J., 06/127 to
   C. M.-H., PI-0252/09 to J. D.-L., and PI-0058/10 to P. P.-M.);
   PI/13/01848; GVA-ACOM2012/238; PI10/OO802/CB12/03/30016 to GS; Fondo
   Europeo de Desarrollo Regional (FEDER). Antonio Camargo is supported by
   an ISCIII research contract (Programa Miguel-Servet CP14/00114). We
   would also like to thank Jose Linares from DEO-LEO, S. A., for providing
   the sunflower oil used in this research, and the Catering School of
   Bodegas Campos in Cordoba, Spain, for cooperating in the standardized
   heating process of the four oils used in the present study.
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NR 54
TC 17
Z9 17
U1 0
U2 25
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1436-6207
EI 1436-6215
J9 EUR J NUTR
JI Eur. J. Nutr.
PD JUN
PY 2017
VL 56
IS 4
BP 1597
EP 1607
DI 10.1007/s00394-016-1205-1
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA EX7ZU
UT WOS:000403469100019
PM 27015911
DA 2025-06-11
ER

PT J
AU Galli, C
   Passeri, G
   Macaluso, GM
AF Galli, C.
   Passeri, G.
   Macaluso, G. M.
TI FoxOs, Wnts and oxidative stress-induced bone loss: new players in the
   periodontitis arena?
SO JOURNAL OF PERIODONTAL RESEARCH
LA English
DT Review
DE periodontal disease; oxidative stress; FoxO; Wnt
ID TOTAL ANTIOXIDANT CAPACITY; FORKHEAD TRANSCRIPTION FACTORS; GINGIVAL
   CREVICULAR FLUID; T-CELL-FACTOR; NF-KAPPA-B; REACTIVE OXYGEN;
   BETA-CATENIN; FREE-RADICALS; METABOLIC SYNDROME; LIPID-PEROXIDATION
AB Background and Objective: Chronic periodontitis is a widespread disease affecting tooth-supporting structures that can lead to extensive loss of periodontal ligament and bone, ultimately resulting in tooth loss. Extensive evidence has demonstrated a strong association between age, metabolic disorders such as type II diabetes, oxidative stress and alveolar bone loss. The molecular players controlling bone maintenance and underlying age-related bone loss and its links to the general metabolism are currently the object of intense research.
   Material and Methods: Recent findings are summarized to elucidate the molecular mechanisms linking oxidative stress, bone loss and metabolic factors.
   Results: It is well known that reactive oxygen species are an inevitable consequence of cellular respiration and that organisms have developed an efficient array of defenses against them. The core of this complex defense line is a family of transcription factors, known as FoxOs, which can bind to beta-catenin and initiate a transcriptional programme regulating cell apoptosis, DNA repair and degradation of reactive oxygen species. An increase in reactive oxygen species due, for example, to age or insulin resistance, generates a situation in which bone formation is impaired by activation of FoxO, and a decrease in Wnt signaling and bone resorption are promoted.
   Conclusion: The balance between FoxO and the Wnt pathway is finely tuned by systemic and local factors, creating a far-reaching mechanism that dictates the fate of mesenchymal progenitors and regulates the homeostasis of bone, providing a rationale for the impairment of systemic and alveolar bone maintenance clinically observed with age and metabolic diseases.
C1 [Galli, C.; Macaluso, G. M.] Univ Parma, Unit Periodont, I-43100 Parma, Italy.
   [Galli, C.; Passeri, G.] Univ Parma, Dept Internal Med, I-43100 Parma, Italy.
C3 University of Parma; University of Parma
RP Galli, C (corresponding author), Univ Parma, Unit Periodont, Via Gramsci 14, I-43100 Parma, Italy.
EM carlo.galli@unipr.it
RI Macaluso, Guido/D-5317-2013; Galli, Carlo/D-4728-2014
OI Passeri, Giovanni/0000-0002-4039-1160; Galli, Carlo/0000-0001-7476-7181
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NR 154
TC 61
Z9 62
U1 0
U2 32
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-3484
EI 1600-0765
J9 J PERIODONTAL RES
JI J. Periodont. Res.
PD AUG
PY 2011
VL 46
IS 4
BP 397
EP 406
DI 10.1111/j.1600-0765.2011.01354.x
PG 10
WC Dentistry, Oral Surgery & Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dentistry, Oral Surgery & Medicine
GA 795ZK
UT WOS:000293018900001
PM 21332475
DA 2025-06-11
ER

PT J
AU Nieuwenhuizen, AG
   Rutters, F
AF Nieuwenhuizen, Arie G.
   Rutters, Femke
TI The hypothalamic-pituitary-adrenal-axis in the regulation of energy
   balance
SO PHYSIOLOGY & BEHAVIOR
LA English
DT Review
DE human; HPA axis functioning; energy balance; body fat percentage;
   dietary restraint; obesity
ID CORTICOTROPIN-RELEASING HORMONE; GLUCOCORTICOID-RECEPTOR GENE; INDUCED
   INSULIN-RESISTANCE; COGNITIVE DIETARY RESTRAINT; BODY-FAT DISTRIBUTION;
   FOOD-INTAKE; EATING BEHAVIOR; CORTISOL SECRETION; CUSHINGS-SYNDROME;
   FEEDING-BEHAVIOR
AB Human (visceral) obesity is associated with alterations hypothalamus-pituitary-adrenal (HPA) axis functioning. It is however not completely clear whether the HPA axis is causally or co-incidentally related to (visceral) obesity. This review summarizes supporting data of an involvement of the HPA axis in the development of (visceral) obesity. First, several DNA polymorphisms related to HPA axis functioning are correlated to the development of obesity. Second, chronic elevation of circulatory glucocorticoid concentrations, as in Cushing's disease, results in increased abdominal adiposity. Third, (visceral) obesity is associated with a diminished capacity of cortisol to suppress its own secretion. HPA axis functioning might affect energy balance through affecting energy intake. Both CRH and cortisol influence physiological, central mechanisms involved in the regulation of food intake. Still, general activation of the HPA axis has shown to have inconsistent effects on food intake in humans. This inconsistency may partially be explained by gender differences, individual differences in the functioning of the HPA axis, as well as differences in attitude towards eating. In particular, women with high scores on dietary restraint are prone to stress-induced hyperphagia. Dietary restraint scores, in turn, are positively correlated to basal and dexamethasone-suppressed cortisol levels, indicating a complex dual relationship between stress, HPA axis functioning, attitude towards eating and the risk for stress-induced hyperphagia. In the Western society, with chronically high ambient levels of stress and the availability of high caloric foods, this relationship may imply a risk for the development of (visceral) obesity and the metabolic syndrome. (C) 2007 Elsevier Inc. All rights reserved.
C1 [Nieuwenhuizen, Arie G.; Rutters, Femke] Maastricht Univ, Dept Human Biol, NL-6200 MD Maastricht, Netherlands.
C3 Maastricht University
RP Rutters, F (corresponding author), Maastricht Univ, Dept Human Biol, POB 616, NL-6200 MD Maastricht, Netherlands.
EM f.rutters@hb.unimaas.nl
OI Nieuwenhuizen, Arie/0000-0003-0999-5422
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NR 118
TC 204
Z9 237
U1 0
U2 41
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0031-9384
J9 PHYSIOL BEHAV
JI Physiol. Behav.
PD MAY 23
PY 2008
VL 94
IS 2
BP 169
EP 177
DI 10.1016/j.physbeh.2007.12.011
PG 9
WC Psychology, Biological; Behavioral Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Behavioral Sciences
GA 311OT
UT WOS:000256610200004
PM 18275977
DA 2025-06-11
ER

PT J
AU Akyol, O
   Chowdhury, I
   Akyol, HR
   Tessier, K
   Vural, H
   Akyol, S
AF Akyol, Omer
   Chowdhury, Imtihan
   Akyol, Hafsa Rana
   Tessier, Kylie
   Vural, Huseyin
   Akyol, Sumeyya
TI Why are cardiovascular diseases more common among patients with severe
   mental illness? The potential involvement of electronegative low-density
   lipoprotein (LDL) L5
SO MEDICAL HYPOTHESES
LA English
DT Article
DE Schizophrenia; Bipolar disorder; Mood disorder; Depression;
   Electronegative LDL (L5); Cardiovascular diseases; Severe mental illness
ID DRUG-NAIVE PATIENTS; MAJOR DEPRESSIVE DISORDER; COLONY-STIMULATING
   FACTOR; TYPE-2 DIABETES-MELLITUS; BIPOLAR I DISORDER; NF-KAPPA-B;
   MYOCARDIAL-INFARCTION; HUMAN PLASMA; METABOLIC SYNDROME; G-CSF
AB Despite tremendous efforts of experimental and clinical studies and knowledge, the pathophysiology of severe mental illness (SMI), including bipolar disorder (BD), unipolar depression (mood disorders, MD), and schizophrenia (SCZ), remains poorly understood. Besides their chronic course and high prevalence in society, mental and somatic comorbidities are really serious problems; patients with these disorders have increased risk of cardiovascular (CV) diseases (CVD) including coronary artery diseases (CAD, i.e. myocardial infarction and angina), stroke, sudden cardiac death, hypertension, cardiomyopathy, arrhythmia, and thromboembolic disease. Although it is determined that triglycerides, cholesterol, glucose, and low-density lipoprotein (LDL) levels are increased in MD and SCZ, the underlying reason remains unknown. Considering this, we propose that electronegative LDL (L5) is probably the main crucial element to understanding CVD induced by SMI and to discovering novel remedial approaches for these diseases. When it is hypothesized that L5 is greatly presupposed in CV system abnormalities, it follows that the anti-L5 therapies and even antioxidant treatment options may open new therapeutic opportunities to prevent CVD diseases secondary to SMI. In this review article, we tried to bring a very original subject to the attention of readers who are interested in lipoprotein metabolism in terms of experimental, clinical, and cell culture studies that corroborate the involvement of L5 in physiopathology of CVD secondary to SMI and also the new therapeutic approaches for these disorders.
C1 [Akyol, Omer] Michigan Math & Sci Acad, Dept Sci, Warren, MI USA.
   [Chowdhury, Imtihan; Tessier, Kylie] Michigan Math & Sci Acad, High Sch, 11th Grade, Warren, MI USA.
   [Akyol, Hafsa Rana] IIT, Biol, Chicago, IL 60616 USA.
   [Vural, Huseyin] RWTH Univ Hosp Aachen, Inst Mol Pathobiochem Expt Gene Therapy & Clin Ch, Aachen, Germany.
   [Akyol, Sumeyya] Beaumont Hlth, Beaumont Res Inst, Royal Oak, MI USA.
C3 Illinois Institute of Technology; RWTH Aachen University; RWTH Aachen
   University Hospital; Beaumont Health
RP Akyol, O (corresponding author), 27300 Dequindre Rd, Warren, MI 48092 USA.
EM akyol@mmsaonline.org
RI Akyol, Sumeyya/AAG-6111-2019
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NR 136
TC 5
Z9 5
U1 2
U2 13
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0306-9877
EI 1532-2777
J9 MED HYPOTHESES
JI Med. Hypotheses
PD SEP
PY 2020
VL 142
AR 109821
DI 10.1016/j.mehy.2020.109821
PG 10
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Research & Experimental Medicine
GA NI2OU
UT WOS:000565195600048
PM 32417641
DA 2025-06-11
ER

PT J
AU Valenzuela, F
   De La Cruz, C
   Lecaros, C
   Fernández, J
   Hevia, G
   Maul, LV
   Thyssen, JP
   Vera-Kellet, C
   Egeberg, A
   Armijo, D
   Pizarro, C
   Riveros, T
   Correa, H
   Guglielmetti, A
   Didaskalu, JA
   Wu, JJ
   Griffiths, CEM
   Romiti, R
   Maul, JT
AF Valenzuela, Fernando
   De La Cruz, Claudia
   Lecaros, Cristobal
   Fernandez, Javier
   Hevia, Gonzalo
   Maul, Lara Valeska
   Thyssen, Jacob P.
   Vera-Kellet, Cristian
   Egeberg, Alexander
   Armijo, Daniela
   Pizarro, Cristian
   Riveros, Tatiana
   Correa, Hernan
   Guglielmetti, Antonio
   Didaskalu, Johannes A.
   Wu, Jashin J.
   Griffiths, Christopher E. M.
   Romiti, Ricardo
   Maul, Julia-Tatjana
TI Comorbidities in Chilean patients with psoriasis: a Global Healthcare
   Study on Psoriasis
SO CLINICAL AND EXPERIMENTAL DERMATOLOGY
LA English
DT Article
ID CUMULATIVE LIFE-COURSE; IMPAIRMENT
AB Background Psoriasis is a chronic inflammatory skin disease associated with several important medical comorbidities. There are scant data available on the comorbidities of patients with psoriasis in South America. Aim To examine the comorbidity profile of adult patients with psoriasis in Chile and its association with severity of psoriasis. Methods This was a multicentre, cross-sectional study involving 16 hospitals and clinics in Chile, which used a 48-item questionnaire to study clinician- and patient-reported outcomes and comorbidities. Inferential analyses were performed by psoriasis severity, using Fisher exact test, Student t-test and multivariable logistic regression. Results In total, 598 adult patients with psoriasis were included (51.1% male; mean age 49.2 +/- 15.1 years); 48.5% mild and 51.4% moderate to severe; Psoriasis Area and Severity Index 11.6 +/- 11.5; body surface area 14.7 +/- 18.2%. Plaque psoriasis was the most common phenotype (90.2%), followed by guttate (13.4%). Psoriatic arthritis occurred in 27.3% of patients. Comorbidities were reported in 60.2% of all patients with psoriasis. Frequent concomitant diseases were obesity (25.3%), hypertension (24.3%), Type 2 diabetes mellitus (T2DM) (18.7%), dyslipidaemia (17.4%), metabolic syndrome (16.7%) and depression (14.4%). After adjustment, significant associations were found between moderate to severe psoriasis and obesity, T2DM and nonalcoholic fatty liver disease (NAFLD) compared with mild psoriasis. Conclusions We report a large study of comorbidities, including depression, dyslipidaemia, T2DM and NAFLD, in people with psoriasis in Chile. The prevalence of comorbidities with psoriasis in Chile appears similar to that found in Western countries, and emphasizes the importance of assessing patients with psoriasis for risk factors for and presence of, comorbid disease in a multidisciplinary setting.
C1 [Valenzuela, Fernando] Univ Chile, Dept Dermatol, Santiago, Chile.
   [Valenzuela, Fernando; Fernandez, Javier] Ctr Int Estudios Clin, Prob Med Res, Santiago, Chile.
   [De La Cruz, Claudia; Armijo, Daniela] Clin Dermacross, Santiago, Chile.
   [Lecaros, Cristobal; Hevia, Gonzalo; Riveros, Tatiana] Univ Desarrollo, Dept Dermatol, Clin Alemana, Santiago, Chile.
   [Maul, Lara Valeska] Univ Hosp Basel, Dept Dermatol, Basel, Switzerland.
   [Thyssen, Jacob P.; Egeberg, Alexander] Bispebjerg Hosp, Dept Dermatol, Copenhagen, Denmark.
   [Thyssen, Jacob P.; Egeberg, Alexander] Univ Copenhagen, Copenhagen, Denmark.
   [Vera-Kellet, Cristian] Pontificia Univ Catolica Chile, Fac Med, Dept Dermatol, Santiago, Chile.
   [Pizarro, Cristian] Univ Austral, Dept Dermatol, Campus Osorno, Osorno, Chile.
   [Correa, Hernan] Ctr Dermatol DERMAMED, Santiago, Chile.
   [Correa, Hernan] Hosp Dr Sotero del Rio, Dept Dermatol, Santiago, Chile.
   [Guglielmetti, Antonio] Univ Valparaiso, Dept Dermatol, Valparaiso, Chile.
   [Didaskalu, Johannes A.; Maul, Julia-Tatjana] Univ Zurich, Fac Med, Zurich, Switzerland.
   [Wu, Jashin J.] Univ Miami, Miller Sch Med, Dept Dermatol, Miami, FL 33136 USA.
   [Griffiths, Christopher E. M.] Univ Manchester, Salford Royal Hosp, Dermatol Ctr, NIHR Manchester Biomed Res Ctr, Manchester, Lancs, England.
   [Griffiths, Christopher E. M.] Univ Manchester, Fac Biol Med & Hlth, Sch Hlth Sci, Manchester, Lancs, England.
   [Romiti, Ricardo] Univ Sao Paulo, Sch Med, Dept Dermatol, Sao Paulo, Brazil.
   [Maul, Julia-Tatjana] Univ Hosp Zurich, Dept Dermatol, Ramistr 100, CH-8091 Zurich, Switzerland.
C3 Universidad de Chile; Universidad del Desarrollo; Clinica Alemana;
   University of Basel; University of Copenhagen; Copenhagen University
   Hospital; Bispebjerg Hospital; University of Copenhagen; Pontificia
   Universidad Catolica de Chile; Universidad Austral de Chile; Universidad
   de Chile; Universidad de Valparaiso; University of Geneva; University of
   Zurich; University of Miami; University of Manchester; Salford Royal NHS
   Foundation Trust; Salford Royal Hospital; University of Manchester;
   Universidade de Sao Paulo; University of Zurich; University Zurich
   Hospital
RP Maul, JT (corresponding author), Univ Hosp Zurich, Dept Dermatol, Ramistr 100, CH-8091 Zurich, Switzerland.
EM julia-tatjana.maul@usz.ch
RI Lecaros, Cristobal/KIC-4516-2024; de la cruz, claudia/KFQ-1718-2024;
   Griffiths, Christopher/P-5448-2014; Valenzuela, Fernando/AAX-5037-2020;
   Vera, Cristian/ABB-9454-2021; Thyssen, Jacob/ABD-8517-2020; Egeberg,
   Alexander/AFO-3479-2022; Maul, Julia-Tatjana/HDM-1043-2022
OI Valenzuela, Fernando/0000-0003-1032-9347; Maul,
   Julia-Tatjana/0000-0002-9914-1545; De la Cruz,
   Claudia/0000-0002-8925-0457; Vera-Kellet, Cristian/0000-0001-8697-9245;
   Lecaros, Cristobal/0000-0002-8509-1188; Armijo,
   Daniela/0000-0002-9801-3277; Didaskalu, Johannes/0000-0001-5145-3921
CR Bachelet V., 2017, STUDY DETERMINATION, P299
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NR 21
TC 6
Z9 6
U1 0
U2 6
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0307-6938
EI 1365-2230
J9 CLIN EXP DERMATOL
JI Clin. Exp. Dermatol.
PD DEC
PY 2022
VL 47
IS 12
BP 2234
EP 2241
DI 10.1111/ced.15384
EA OCT 2022
PG 8
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 6R2NL
UT WOS:000875468700001
PM 35988043
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Chen, T
   Yao, L
   Ke, DZ
   Cao, WG
   Zuo, GW
   Zhou, L
   Jiang, J
   Yamahara, J
   Li, YH
   Wang, JW
AF Chen, Ting
   Yao, Ling
   Ke, Dazhi
   Cao, Weiguo
   Zuo, Guowei
   Zhou, Liang
   Jiang, Jian
   Yamahara, Johji
   Li, Yuhao
   Wang, Jianwei
TI Treatment with Rhodiola crenulata root extract ameliorates
   insulin resistance in fructose-fed rats by modulating sarcolemmal and
   intracellular fatty acid translocase/CD36 redistribution in skeletal
   muscle
SO BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Article
DE Fatty acid translocase/CD36; Insulin resistance; Rhodiola; Sarcolemma
ID METABOLIC SYNDROME; NONALCOHOLIC STEATOHEPATITIS; AFFECTIVE-DISORDERS;
   MAJOR DEPRESSION; LIPID-METABOLISM; OBESITY; TRANSPORTERS; DISEASE;
   GLUCOSE; PIOGLITAZONE
AB Background: Rhodiola species have been used for asthenia, depression, fatigue, poor work performance and cardiovascular diseases, all of which may be associated with insulin resistance. To disclose the underlying mechanisms of action, the effect of Rhodiola crenulata root (RCR) on insulin resistance was investigated.
   Methods: Male Sprague-Dawley rats were treated with liquid fructose in their drinking water over 18 weeks. The extract of RCR was co-administered (once daily by oral gavage) during the last 5 weeks. The indexes of lipid and glucose homeostasis were determined enzymatically and/or by ELISA. Gene expression was analyzed by Real-time PCR, Western blot and/or confocal immunofluorescence.
   Results: RCR extract (50 mg/kg) suppressed fructose-induced hyperinsulinemia and the increases in the homeostasis model assessment of insulin resistance index and the adipose tissue insulin resistance index in rats. Additionally, this treatment had a trend to restore the ratios of glucose to insulin and non-esterified fatty acids (NEFA) to insulin. Mechanistically, RCR suppressed fructose-induced acceleration of the clearance of plasma NEFA during oral glucose tolerance test (OGTT), and decreased triglyceride content and Oil Red O staining area in the gastrocnemius. Furthermore, RCR restored fructose-induced sarcolemmal overexpression and intracellular less distribution of fatty acid translocase/CD36 that contributes to etiology of insulin resistance by facilitating fatty acid uptake.
   Conclusion: These results suggest that RCR ameliorates insulin resistance in fructose-fed rats by modulating sarcolemmal and intracellular CD36 redistribution in the skeletal muscle. Our findings may provide a better understanding of the traditional use of Rhodila species.
C1 [Chen, Ting; Zhou, Liang] Chongqing Med Univ, Fac Basic Med Sci, Chongqing 400016, Peoples R China.
   [Yao, Ling; Cao, Weiguo; Li, Yuhao; Wang, Jianwei] Chongqing Med Univ, Lab Tradit Chinese Med, Chongqing 400016, Peoples R China.
   [Ke, Dazhi] Chongqing Med Univ, Affiliated Hosp 2, Chongqing 400010, Peoples R China.
   [Zuo, Guowei] Chongqing Med Univ, Coll Lab Med, Chongqing 400016, Peoples R China.
   [Jiang, Jian] Sydney Inst Tradit Chinese Med, Sydney Inst Hlth Sci, Endocrinol & Metab Grp, Sydney, NSW 2000, Australia.
   [Yamahara, Johji] Pharmafood Inst, Kyoto 6028136, Japan.
C3 Chongqing Medical University; Chongqing Medical University; Chongqing
   Medical University; Chongqing Medical University
RP Li, YH; Wang, JW (corresponding author), Chongqing Med Univ, Lab Tradit Chinese Med, Chongqing 400016, Peoples R China.
EM yuhao@sitcm.edu.au; wjwcq68@163.com
FU National Natural Science Foundation of China, China [81374033]; Natural
   Science Foundation of Chongqing Medical University, China [X12100];
   Chongqing Science and Technology Commission, China [cstc2013jcyjA10051];
   R&D Agency for Curative Natural Products (a Japanese
   government-registered non-profit organization), Kyoto, Japan
FX This work was financially supported by the National Natural Science
   Foundation of China, China (Grant No: 81374033), the Natural Science
   Foundation of Chongqing Medical University, China (Grant No: X12100),
   Chongqing Science and Technology Commission, China (Grant No:
   cstc2013jcyjA10051), and R&D Agency for Curative Natural Products (a
   Japanese government-registered non-profit organization), Kyoto, Japan.
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NR 52
TC 6
Z9 7
U1 2
U2 15
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1472-6882
J9 BMC COMPLEM ALTERN M
JI BMC Complement. Altern. Med.
PD JUL 12
PY 2016
VL 16
AR 209
DI 10.1186/s12906-016-1176-z
PG 13
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA DR3RC
UT WOS:000379819300002
PM 27405506
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Dinh, E
   Rival, T
   Carrier, A
   Asfogo, N
   Corti, O
   Melon, C
   Salin, P
   Lortet, S
   Kerkerian-Le Goff, L
AF Dinh, Emilie
   Rival, Thomas
   Carrier, Alice
   Asfogo, Noemi
   Corti, Olga
   Melon, Christophe
   Salin, Pascal
   Lortet, Sylviane
   Kerkerian-Le Goff, Lydia
TI TP53INP1 exerts neuroprotection under ageing and Parkinson's
   disease-related stress condition
SO CELL DEATH & DISEASE
LA English
DT Article
ID SUBSTANTIA-NIGRA; TARGETED OVEREXPRESSION; ALPHA-SYNUCLEIN; AUTOPHAGY;
   PROMOTES; PINK1; GENES; DYSFUNCTION; PATHOLOGY; NEURONS
AB TP53INP1 is a stress-induced protein, which acts as a dual positive regulator of transcription and of autophagy and whose deficiency has been linked with cancer and metabolic syndrome. Here, we addressed the unexplored role of TP53INP1 and of its Drosophila homolog dDOR in the maintenance of neuronal homeostasis under chronic stress, focusing on dopamine (DA) neurons under normal ageing- and Parkinson's disease (PD)-related context. Trp53inp1(-/-) mice displayed additional loss of DA neurons in the substantia nigra compared to wild-type (WT) mice, both with ageing and in a PD model based on targeted overexpression of alpha-synuclein. Nigral Trp53inp1 expression of WT mice was not significantly modified with ageing but was markedly increased in the PD model. Trp53inp2 expression showed similar evolution and did not differ between WT and Trp53inp1(-/-) mice. In Drosophila, pan-neuronal dDOR overexpression improved survival under paraquat exposure and mitigated the progressive locomotor decline and the loss of DA neurons caused by the human alpha-synuclein A30P variant. dDOR overexpression in DA neurons also rescued the locomotor deficit in flies with RNAi-induced downregulation of dPINK1 or dParkin. Live imaging, confocal and electron microscopy in fat bodies, neurons, and indirect flight muscles showed that dDOR acts as a positive regulator of basal autophagy and mitophagy independently of the PINK1-mediated pathway. Analyses in a mammalian cell model confirmed that modulating TP53INP1 levels does not impact mitochondrial stress-induced PINK1/Parkin-dependent mitophagy. These data provide the first evidence for a neuroprotective role of TP53INP1/dDOR and highlight its involvement in the regulation of autophagy and mitophagy in neurons.
C1 [Dinh, Emilie; Rival, Thomas; Melon, Christophe; Salin, Pascal; Lortet, Sylviane; Kerkerian-Le Goff, Lydia] Aix Marseille Univ, NeuroMarseille, IBDM, CNRS, Marseille, France.
   [Carrier, Alice] Aix Marseille Univ, Inst Paoli Calmettes, CRCM, INSERM,CNRS, Marseille, France.
   [Asfogo, Noemi; Corti, Olga] Sorbonne Univ, Inst Cerveau, Hop Pitie Salpetriere, AP HP,Paris Brain Inst ICM,CNRS, Paris, France.
C3 Centre National de la Recherche Scientifique (CNRS); Aix-Marseille
   Universite; Institut National de la Sante et de la Recherche Medicale
   (Inserm); Aix-Marseille Universite; UNICANCER; Institut Paoli-Calmette
   (IPC); Centre National de la Recherche Scientifique (CNRS); Sorbonne
   Universite; Institut National de la Sante et de la Recherche Medicale
   (Inserm); Assistance Publique Hopitaux Paris (APHP); Hopital
   Universitaire Pitie-Salpetriere - APHP; Centre National de la Recherche
   Scientifique (CNRS)
RP Kerkerian-Le Goff, L (corresponding author), Aix Marseille Univ, NeuroMarseille, IBDM, CNRS, Marseille, France.
EM lydia.kerkerian-le-groff@univ-amu.fr
RI Corti, Olga/ABO-8641-2022; Corti, Olga/I-4981-2016
OI Lortet, Sylviane/0000-0002-7169-4375; RIVAL, Thomas/0000-0002-1324-2661;
   Asfogo, Noemi/0009-0003-0674-1440; Corti, Olga/0000-0003-2093-7389;
   Kerkerian-Le Goff, Lydia/0000-0002-7951-3479
FU Federation pour la Recherche sur le Cerveau (FRC); CNRS; INSERM;
   Aix-Marseille University; Investissement d'Avenir [ANR-10-IAIHU-06];
   Innovative Medecines Initiative 2 Joint Undertaking [821522]; European
   Union's Horizon 2020 Research and Innovation program; EFPIA; Parkinson's
   UK; French Ministry of Higher Education, Innovation and Research
FX This work was funded by a grant from Federation pour la Recherche sur le
   Cerveau (FRC) and was supported by CNRS, INSERM and Aix-Marseille
   University. It also benefited of support from "Investissement d'Avenir"
   ANR-10-IAIHU-06 and the Innovative Medecines Initiative 2 Joint
   Undertaking under grant agreement No 821522 (PD-MitoQUANT; this joint
   undertaking receives support from the European Union's Horizon 2020
   Research and Innovation program and EFPIA and Parkinson's UK. ED was
   supported by a PhD fellowship from the French Ministry of Higher
   Education, Innovation and Research.
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NR 60
TC 10
Z9 12
U1 0
U2 6
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 2041-4889
J9 CELL DEATH DIS
JI Cell Death Dis.
PD MAY 8
PY 2021
VL 12
IS 5
AR 460
DI 10.1038/s41419-021-03742-4
PG 19
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA SK3XH
UT WOS:000656151800002
PM 33966044
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Xie, MR
   Tang, QM
   Nie, JM
   Zhang, C
   Zhou, X
   Yu, SL
   Sun, JW
   Cheng, X
   Dong, NG
   Hu, Y
   Chen, LL
AF Xie, Mengru
   Tang, Qingming
   Nie, Jiaming
   Zhang, Chao
   Zhou, Xin
   Yu, Shaoling
   Sun, Jiwei
   Cheng, Xiang
   Dong, Nianguo
   Hu, Yu
   Chen, Lili
TI BMAL1-Downregulation Aggravates Porphyromonas Gingivalis-Induced
   Atherosclerosis by Encouraging Oxidative Stress
SO CIRCULATION RESEARCH
LA English
DT Article
DE atherosclerosis; circadian rhythm; NF-kappa B signaling; oxidative
   stress; Porphyromonas gingivalis
ID NF-KAPPA-B; RISK-FACTORS; CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME;
   VASCULAR-DISEASE; PROGRESSION; CLOCK; BMAL1; ROS; MACROPHAGES
AB Rationale:
   Atherosclerotic cardiovascular diseases are the leading cause of mortality worldwide. Atherosclerotic cardiovascular diseases are considered as chronic inflammation processes. In addition to risk factors associated with the cardiovascular system itself, pathogenic bacteria such as the periodontitis-associated Porphyromonas gingivalis (P gingivalis) are also closely correlated with the development of atherosclerosis, but the underlying mechanisms are still elusive.
   Objective:
   To elucidate the mechanisms of P gingivalis-accelerated atherosclerosis and explore novel therapeutic strategies of atherosclerotic cardiovascular diseases.
   Methods and Results:
   Bmal1(-/-) (brain and muscle Arnt-like protein 1) mice, ApoE(-/-) mice, Bmal1(-/-)ApoE(-/-) mice, conditional endothelial cell Bmal1 knockout mice (Bmal1(fl/fl); Tek-Cre mice), and the corresponding jet-legged mouse model were used. P gingivalis accelerates atherosclerosis progression by triggering arterial oxidative stress and inflammatory responses in ApoE(-/-) mice, accompanied by the perturbed circadian clock. Circadian clock disruption boosts P gingivalis-induced atherosclerosis progression. The mechanistic dissection shows that P gingivalis infection activates the TLRs-NF-kappa B signaling axis, which subsequently recruits DNMT-1 to methylate the BMAL1 promoter and thus suppresses BMAL1 transcription. The downregulation of BMAL1 releases CLOCK, which phosphorylates p65 and further enhances NF-kappa B signaling, elevating oxidative stress and inflammatory response in human aortic endothelial cells. Besides, the mouse model exhibits that joint administration of metronidazole and melatonin serves as an effective strategy for treating atherosclerotic cardiovascular diseases.
   Conclusions:
   P gingivalis accelerates atherosclerosis via the NF-kappa B-BMAL1-NF-kappa B signaling loop. Melatonin and metronidazole are promising auxiliary medications toward atherosclerotic cardiovascular diseases.
C1 [Xie, Mengru; Tang, Qingming; Nie, Jiaming; Zhou, Xin; Yu, Shaoling; Sun, Jiwei; Chen, Lili] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Stomatol, 1277 Jiefang Ave, Wuhan 430022, Peoples R China.
   [Xie, Mengru; Tang, Qingming; Nie, Jiaming; Zhou, Xin; Yu, Shaoling; Sun, Jiwei; Chen, Lili] Hubei Prov Key Lab Oral & Maxillofacial Dev & Reg, Wuhan 430022, Peoples R China.
   [Hu, Yu] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Inst Hematol, 1277 Jiefang Ave, Wuhan 430022, Peoples R China.
   [Zhang, Chao; Dong, Nianguo] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Cardiovasc Surg, Wuhan, Peoples R China.
   [Cheng, Xiang] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Cardiol, Wuhan, Peoples R China.
C3 Huazhong University of Science & Technology; Huazhong University of
   Science & Technology; Huazhong University of Science & Technology;
   Huazhong University of Science & Technology
RP Chen, LL (corresponding author), Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Stomatol, 1277 Jiefang Ave, Wuhan 430022, Peoples R China.; Chen, LL (corresponding author), Hubei Prov Key Lab Oral & Maxillofacial Dev & Reg, Wuhan 430022, Peoples R China.; Hu, Y (corresponding author), Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Inst Hematol, 1277 Jiefang Ave, Wuhan 430022, Peoples R China.
EM dr_huyu@126.com; lily-c1030@163.com
RI Chen, Lili/HJY-7871-2023
OI Chen, Lili/0000-0002-9965-8990; Nie, Jiaming/0009-0003-2474-8128
FU National Science Foundation for Distinguished Young Scholars of China
   [31725011]; Young Scientists of China [81800986]; Chinese Stomatological
   Association [CSA-Z2015-01]
FX This work was supported by the National Science Foundation for
   Distinguished Young Scholars of China (31725011 to L. Chen) and Young
   Scientists of China (81800986 to Q. Tang), and Chinese Stomatological
   Association (CSA-Z2015-01 to L. Chen).
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NR 59
TC 164
Z9 181
U1 9
U2 100
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0009-7330
EI 1524-4571
J9 CIRC RES
JI Circ.Res.
PD MAR 13
PY 2020
VL 126
IS 6
BP E15
EP E29
DI 10.1161/CIRCRESAHA.119.315502
PG 15
WC Cardiac & Cardiovascular Systems; Hematology; Peripheral Vascular
   Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Hematology
GA LG3SR
UT WOS:000528025200001
PM 32078488
OA Bronze
DA 2025-06-11
ER

PT J
AU Liu, ZX
   Dou, WJ
   Ni, Z
   Wen, QS
   Zhang, R
   Qin, M
   Wang, XX
   Tang, H
   Cao, Y
   Wang, JJ
   Zhao, SG
AF Liu, Zhenxiong
   Dou, Weijia
   Ni, Zhen
   Wen, Qinsheng
   Zhang, Rong
   Qin, Ming
   Wang, Xuxia
   Tang, Hua
   Cao, Ying
   Wang, Jingjie
   Zhao, Shuguang
TI Deletion of Nrf2 leads to hepatic insulin resistance via the activation
   of NF-κB in mice fed a high-fat diet
SO MOLECULAR MEDICINE REPORTS
LA English
DT Article
DE non-alcoholic fatty liver disease; insulin resistance; oxidative stress;
   nuclear erythroid 2-related factor 2; nuclear factor-kappa B
ID LIVER-DISEASE; OXIDATIVE STRESS; TRANSCRIPTION FACTOR; IKK-BETA;
   STEATOHEPATITIS; INFLAMMATION; MECHANISMS; PATHOGENESIS; PROGRESSION;
   CELLS
AB Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of the metabolic syndrome. Insulin resistance (IR) is important in the development and progression of NAFLD. Nuclear erythroid 2-related factor 2 (Nrf2) has previously been reported to be a novel regulator in NAFLD. The present study determined that Nrf2 knockdown accelerated the onset of obesity and non-alcoholic steatohepatitis (NASH), via the induction of hepatic IR in mice fed a high-fat diet (HFD), which was confirmed by an increase in total and hepatic weight in Nrf2-null-HFD mice, in addition to marked structural disorder in liver tissues from the Nrf2-null-HFD group analyzed by histopathological examination. Subsequently, it was demonstrated that hepatic IR in Nrf2-null-HFD mice was influenced by oxidative stress; this was confirmed by an increase in malondialdehyde levels and a decrease in glutathione levels. In addition, it was determined that the induction of hepatic IR by Nrf2 knockdown in HFD-treated mice was regulated by activation of the nuclear factor-kappa B (NF-kappa B) signaling pathway, as detected by an increase in the expression levels of nuclear NF-kappa B, and its downstream effectors interleukin-6 and tumor necrosis factor-alpha. The present study provides insight into the function of Nrf2 in NAFLD, indicating that Nrf2 deletion may lead to hepatic IR by activation of NF-kappa B, which is often associated with oxidative stress. Therefore, activation of Nrf2 may limit disease progression and act as a therapeutic approach for the treatment of NASH.
C1 [Liu, Zhenxiong; Dou, Weijia; Wen, Qinsheng; Qin, Ming; Wang, Xuxia; Tang, Hua; Cao, Ying; Wang, Jingjie; Zhao, Shuguang] Fourth Mil Med Univ, Tangdu Hosp, Dept Gastroenterol, 569 Xinsi Rd, Xian 710038, Shaanxi, Peoples R China.
   [Ni, Zhen] Gen Hosp Chengdu Mil Command, Dept Digest, Chengdu 610000, Sichuan, Peoples R China.
   [Zhang, Rong] Yanan Univ, Xianyang Hosp, Dept Gastroenterol, Xianyang 712000, Shaanxi, Peoples R China.
C3 Air Force Medical University; Yanan University
RP Wang, JJ; Zhao, SG (corresponding author), Fourth Mil Med Univ, Tangdu Hosp, Dept Gastroenterol, 569 Xinsi Rd, Xian 710038, Shaanxi, Peoples R China.
EM jingjie@fmmu.edu.cn; zsg1203@126.com
FU National Natural Science Foundation of China [30800515, 81270485,
   81170376]; Natural Science Foundation of Shaanxi Province [2013JM4021]
FX The present study was supported by the National Natural Science
   Foundation of China (grant nos. 30800515, 81270485 and 81170376) and the
   Natural Science Foundation of Shaanxi Province (grant no. 2013JM4021).
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NR 37
TC 49
Z9 55
U1 2
U2 23
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1791-2997
EI 1791-3004
J9 MOL MED REP
JI Mol. Med. Rep.
PD AUG
PY 2016
VL 14
IS 2
BP 1323
EP 1331
DI 10.3892/mmr.2016.5393
PG 9
WC Oncology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Research & Experimental Medicine
GA DQ9UK
UT WOS:000379554600038
PM 27315552
DA 2025-06-11
ER

PT J
AU Hu, YC
   Huang, TC
   Huang, LW
   Cheng, HL
   Hsieh, BS
   Chang, KL
AF Hu, Yu-Chen
   Huang, Tzu-Ching
   Huang, Li-Wen
   Cheng, Hsiao-Ling
   Hsieh, Bau-Shan
   Chang, Kee-Lung
TI S-Equol Ameliorates Menopausal Osteoarthritis in Rats through Reducing
   Oxidative Stress and Cartilage Degradation
SO NUTRIENTS
LA English
DT Article
DE S-equol; isoflavones; osteoarthritis; degenerative joint disease;
   menopause
ID II COLLAGEN DEGRADATION; KNEE OSTEOARTHRITIS; SUBCHONDRAL BONE;
   OVARIECTOMIZED RATS; METABOLIC SYNDROME; RISK-FACTORS; POSTMENOPAUSAL
   WOMEN; HAND OSTEOARTHRITIS; ARTICULAR-CARTILAGE; ESTROGEN THERAPY
AB Osteoarthritis (OA) is a chronic degenerative disease leading to articular cartilage destruction. Menopausal and postmenopausal women are susceptible to both OA and osteoporosis. S-equol, a soy isoflavone-derived molecule, is known to reduce osteoporosis in estrogen-deficient mice, but its role in OA remains unknown. This study aimed to explore the effect of S-equol on different degrees of menopausal OA in female Sprague-Dawley (SD) rats induced by estrogen deficiency caused by bilateral ovariectomy (OVX) combined with intra-articular injection of mono-iodoacetate (MIA). Knee joint histopathological change; serum biomarkers of bone turnover, including N-terminal propeptide of type I procollagen (PINP), C-terminal telopeptide of type I collagen (CTX-I) and N-terminal telopeptide of type I collagen (NTX-I); the cartilage degradation biomarkers hyaluronic acid (HA) and N-terminal propeptide of type II procollagen (PIINP); and the matrix-degrading enzymes matrix metalloproteinases (MMP)-1, MMP-3 and MMP-13, as well as the oxidative stress-inducing molecules nitric oxide (NO) and hydrogen peroxide (H2O2), were assessed for evaluation of OA progression after S-equol supplementation for 8 weeks. The results showed that OVX without or with MIA injection induced various severity levels of menopausal OA by increasing pathological damage, oxidative stress, and cartilage matrix degradation to various degrees. Moreover, S-equol supplementation could significantly reduce these increased biomarkers in different severity levels of OA. This indicates that S-equol can lessen menopausal OA progression by reducing oxidative stress and the matrix-degrading enzymes involved in cartilage degradation.
C1 [Hu, Yu-Chen; Huang, Tzu-Ching; Hsieh, Bau-Shan; Chang, Kee-Lung] Kaohsiung Med Univ, Coll Med, Sch Med, Dept Biochem, Kaohsiung 807378, Taiwan.
   [Hu, Yu-Chen; Huang, Tzu-Ching; Hsieh, Bau-Shan; Chang, Kee-Lung] Kaohsiung Med Univ, Grad Inst Med, Coll Med, Kaohsiung 807378, Taiwan.
   [Huang, Li-Wen] Kaohsiung Med Univ, Coll Hlth Sci, Dept Med Lab Sci & Biotechnol, Kaohsiung 807378, Taiwan.
   [Cheng, Hsiao-Ling] Kaohsiung Municipal Minsheng Hosp, Dept Pharm, Kaohsiung 802511, Taiwan.
C3 Kaohsiung Medical University; Kaohsiung Medical University; Kaohsiung
   Medical University
RP Chang, KL (corresponding author), Kaohsiung Med Univ, Coll Med, Sch Med, Dept Biochem, Kaohsiung 807378, Taiwan.; Chang, KL (corresponding author), Kaohsiung Med Univ, Grad Inst Med, Coll Med, Kaohsiung 807378, Taiwan.
EM huyujena@gmail.com; huangtavia@gmail.com; lewehu@cc.kmu.edu.tw;
   chenghl.tanya@gmail.com; hsiehbs@gmail.com; keeluch@kmu.edu.tw
RI Chang, Kee-Lung/D-5512-2009; Hsieh, Bau/A-3229-2011
OI Chang, Kee-Lung/0000-0002-9801-6355; Hu, Yu-Chen/0000-0002-0713-770X
FU National Science and Technology Council, Taipei City, Taiwan
   [108-2320-B-037-030-MY3, 110-2811-B-037-515, 112-2320-B-037-013-]
FX This work was partially supported by a grant from the National Science
   and Technology Council, Taipei City, Taiwan (108-2320-B-037-030-MY3), by
   a grant from the National Science and Technology Council, Taipei City,
   Taiwan (110-2811-B-037-515), and by a grant from the National Science
   and Technology Council, Taipei City, Taiwan (112-2320-B-037-013-).
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NR 81
TC 1
Z9 1
U1 2
U2 2
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JUL
PY 2024
VL 16
IS 14
AR 2364
DI 10.3390/nu16142364
PG 14
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA ZS7K7
UT WOS:001277344700001
PM 39064807
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Liu, L
   Shen, Q
   Wang, Y
   Li, H
   Zhao, JS
AF Liu, Lin
   Shen, Quan
   Wang, Yan
   Li, Hong
   Zhao, Jingshan
TI Dihydromyricetin Alleviates Nonalcoholic Fatty Liver Disease and Its
   Associated Metabolic Syndrome by Inhibiting Endoplasmic Reticulum Stress
   in LDLR<SUP>-/-</SUP> Mice Fed with a High-Fat and High-Fructose Diet
SO JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS
LA English
DT Article
ID RAT PLASMA; LC-MS/MS; MECHANISMS
AB Nonalcoholic fatty liver disease (NAFLD) is a chronic liver disease. Previous studies have shown that dihydromyricetin (DHM) is beneficial for NAFLD. However, whether DHM alleviates NAFLD by inhibiting liver endoplasmic reticulum (ER) stress remains unknown. Thus, this study aimed to identify the potential roles and mechanisms of DHM. Twenty-four male low-density lipoprotein receptor (LDLR-/-) knockout mice aged 8 weeks were randomly divided into normal control, control, and DHM groups. Normal control mice were fed a normal diet (ND), and the last two groups of mice were fed a high-fat and high-fructose diet (HFD) for 12 weeks, treated with or without DHM. DHM alleviated diet-induced hyperlipidemia as early as 4 weeks after and until the end of HFD feeding. HFD increased insulin resistance, and the opposite was observed in the DHM group. Compared to the control group, the body weight of the mice and adipocyte size and weight of the retroperitoneal and epididymal fat were remarkably reduced in the DHM group. The expression of genes related to lipid metabolism, such as Acox1 and Cpt1 & alpha;, was significantly upregulated. Moreover, Mttp was downregulated in the two fat sits in the DHM group. DHM alleviated diet-induced lipid deposition in the liver and decreased liver triglyceride and total cholesterol content. DHM improved liver function by inhibiting ER stress, alleviating atherogenesis, and promoting vascular remodeling. In conclusion, dihydromyricetin improved NAFLD and related insulin resistance, hyperlipidemia, and atherogenesis by inhibiting liver ER stress in HFD-fed LDLR-/- mice.
C1 [Liu, Lin; Zhao, Jingshan] Hebei Univ Chinese Med, Coll Basic Med, Dept Biochem & Mol Biol, Shijiazhuang 050200, Hebei, Peoples R China.
   [Shen, Quan; Zhao, Jingshan] Tradit Chinese Med Proc Technol Innovat Ctr Hebei, Shijiazhuang 050200, Hebei, Peoples R China.
   [Shen, Quan; Zhao, Jingshan] Hebei Univ Chinese Med, Coll Pharm, Shijiazhuang 050200, Hebei, Peoples R China.
   [Wang, Yan] Hebei Univ Chinese Med, Coll Nursing, Dept Med Nursing, Shijiazhuang 050200, Hebei, Peoples R China.
   [Li, Hong] Shijiazhuang Engn Vocat Coll, Coll Sci, Shijiazhuang 050200, Hebei, Peoples R China.
C3 Hebei University of Chinese Medicine; Hebei University of Chinese
   Medicine; Hebei University of Chinese Medicine
RP Zhao, JS (corresponding author), Hebei Univ Chinese Med, Coll Basic Med, Dept Biochem & Mol Biol, Shijiazhuang 050200, Hebei, Peoples R China.; Zhao, JS (corresponding author), Tradit Chinese Med Proc Technol Innovat Ctr Hebei, Shijiazhuang 050200, Hebei, Peoples R China.; Zhao, JS (corresponding author), Hebei Univ Chinese Med, Coll Pharm, Shijiazhuang 050200, Hebei, Peoples R China.
EM liulin1234@163.com; 670913462@qq.com; 935497550@qq.com;
   371028052@163.com; zhaojingshan@hebcm.edu.cn
FU Science and Technology Department of Hebei Province [223777149D];
   Natural Science Foundation of Hebei Province [H2020423061]; Science and
   Technology Project of Hebei Education Department [QN2022092]; Hebei
   Traditional Chinese Medicine Administration [2022080, 2017009]; Medical
   Science Research Project of Hebei Provincial Health Commission
   [20231564, BSZ2021007]
FX This research was funded by the Science and Technology Department of
   Hebei Province, 223777149D, and Natural Science Foundation of Hebei
   Province, H2020423061, to J. Z.; Science and Technology Project of Hebei
   Education Department, QN2022092, to L. L.; Hebei Traditional Chinese
   Medicine Administration, 2022080, to L. L. and, 2017009, to J. Z.;
   Medical Science Research Project of Hebei Provincial Health Commission,
   20231564, to L. L.; and Dr. Fund of Hebei University of Chinese
   Medicine, BSZ2021007, to L. L.
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NR 30
TC 1
Z9 1
U1 2
U2 9
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0269-4727
EI 1365-2710
J9 J CLIN PHARM THER
JI J. Clin. Pharm. Ther.
PD AUG 8
PY 2023
VL 2023
AR 5029934
DI 10.1155/2023/5029934
PG 12
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA P5MN1
UT WOS:001051117300001
OA gold
DA 2025-06-11
ER

PT J
AU Funes, A
   Lancellotti, TES
   Santillan, LD
   Della Vedova, MC
   Monclus, MA
   Cabrillana, ME
   Mejiba, SEG
   Ramirez, DC
   Fornes, MW
AF Funes, A.
   Saez Lancellotti, T. E.
   Santillan, L. D.
   Della Vedova, M. C.
   Monclus, M. A.
   Cabrillana, M. E.
   Gomez Mejiba, S. E.
   Ramirez, D. C.
   Fornes, M. W.
TI A chronic high-fat diet causes sperm head alterations in C57BL/6J mice
SO HELIYON
LA English
DT Article
DE Cell biology; Immunology; Molecular biology; Proteins; Diet; Male
   fertility; Mouse model; Inflammation; Sperm-head morphology; Dietary
   fat; Oxidative stress
ID MALE-FERTILITY; OBESITY; INFLAMMATION; INFERTILITY; IMPACT; PARAMETERS;
   CYTOKINES; STRESS; LEPTIN; TRACT
AB A chronic-positive energetic balance has been directly correlated with infertility in men, but the involved mechanisms remain unknown. Herein we investigated weather in a mouse model a chronic feeding with a diet supplemented with chicken fat affects sperm head morphology. To accomplish this, we fed mice for 16 weeks with either control food (low-fat diet, LFD) or control food supplemented with 22% chicken fat (high-fat diet, HFD). At the end of the feeding regimen, we measured: redox and inflammatory changes, cholesterol accumulation in testis and analyzed testicular morphological structure and ultra-structure and liver morphology. We found that the mice fed HFD resembled some features of the human metabolic syndrome, including systemic oxidative stress and inflammation, this group showed an increment in the following parameters; central adiposity (adiposity index: 1.07 +/- 0.10 vs 2.26 +/- 0.17), dyslipidemia (total cholesterol: 153.3 +/- 2.6 vs 175.1 +/- 8.08 mg/dL), insulin resistance (indirect Insulin resistance index, TG/HDL-c: 2.94 +/- 0.33 vs 3.68 +/- 0.15) and fatty liver. Increased cholesterol content measured by filipin was found in the testicles from HFD (fluorescence intensity increase to 50%), as well as an alteration of spermiogenesis. Most remarkably, a disorganized manchette-perinuclear ring complex and an altered morphology of the sperm head were observed in the spermatozoa of HFD-fed mice. These results add new information to our understanding about the mechanisms by which systemic oxidative stress and inflammation may influence sperm-head morphology and indirectly male fertility.
C1 [Funes, A.; Saez Lancellotti, T. E.; Monclus, M. A.; Cabrillana, M. E.; Fornes, M. W.] Natl Univ Cuyo, Androl Res Lab Mendoza, LIAM, IHEM CCT CONICET, RA-5500 Mendoza, Argentina.
   [Funes, A.; Saez Lancellotti, T. E.; Monclus, M. A.; Cabrillana, M. E.; Fornes, M. W.] Univ Aconcagua, RA-5500 Mendoza, Argentina.
   [Santillan, L. D.; Della Vedova, M. C.; Ramirez, D. C.] Natl Univ San Luis, CONICET, IMIBIO SL, Lab Expt & Translat Med, RA-5700 San Luis, Argentina.
   [Gomez Mejiba, S. E.] Natl Univ San Luis, CONICET, IMIBIO SL, Lab Expt Therapeut, RA-5700 San Luis, Argentina.
C3 University Nacional Cuyo Mendoza; Consejo Nacional de Investigaciones
   Cientificas y Tecnicas (CONICET); Universidad Nacional de San Luis;
   Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET);
   Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET);
   Universidad Nacional de San Luis
RP Fornes, MW (corresponding author), Natl Univ Cuyo, Androl Res Lab Mendoza, LIAM, IHEM CCT CONICET, RA-5500 Mendoza, Argentina.; Fornes, MW (corresponding author), Univ Aconcagua, RA-5500 Mendoza, Argentina.; Ramirez, DC (corresponding author), Natl Univ San Luis, CONICET, IMIBIO SL, Lab Expt & Translat Med, RA-5700 San Luis, Argentina.
EM ramirezlabimbiosl@ymail.com; mfornes@fcm.uncu.edu.ar
RI Saez Lancellotti, Estefanía/AHE-5495-2022; RAMIREZ, DARIO/K-3312-2013
OI Saez Lancellotti, T Estefania/0000-0001-8830-6482; Funes,
   Abi/0000-0002-6540-3324; RAMIREZ, DARIO/0000-0001-6725-3326; Cabrillana,
   Maria Eugenia/0000-0001-6794-8603
FU Program from SECTyP, National University of Cuyo; CIUDA, University of
   Aconcagua, Argentina; Agencia Nacional para la Promocion de la Ciencia y
   la Tecnologia-FONCyT, Argentina [PICT-2014-3369]; Universidad Nacional
   de San Luis, Argentina [PROICO 02-3418, PROICO 10-0218]; CONICET
   [PIP-916]
FX This work was supported by the Program from SECTyP, National University
   of Cuyo; CIUDA, University of Aconcagua, Argentina and by the Agencia
   Nacional para la Promocion de la Ciencia y la Tecnologia-FONCyT,
   Argentina (PICT-2014-3369), Universidad Nacional de San Luis, Argentina
   (PROICO 02-3418 to DCR, PROICO 10-0218), and the CONICET (PIP-916).
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NR 40
TC 15
Z9 16
U1 0
U2 9
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
EI 2405-8440
J9 HELIYON
JI Heliyon
PD NOV
PY 2019
VL 5
IS 11
AR e02868
DI 10.1016/j.heliyon.2019.e02868
PG 6
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA JS8CO
UT WOS:000500530100125
PM 31844747
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Mrug, S
   Mrug, M
   Anjana, MM
   Reynolds, N
   Patel, A
   Hill, DC
   Feig, DI
AF Mrug, Sylvie
   Mrug, Michel
   Morris, Anjana Madan
   Reynolds, Nina
   Patel, Anita
   Hill, Danielle C.
   Feig, Daniel I.
TI Uric Acid Excretion Predicts Increased Blood Pressure Among American
   Adolescents of African Descent
SO AMERICAN JOURNAL OF THE MEDICAL SCIENCES
LA English
DT Article
DE Uric acid; Blood pressure; Pediatric; African American
ID CARDIOVASCULAR RISK; METABOLIC SYNDROME; URINARY-EXCRETION; SERUM URATE;
   HYPERTENSION; CHILDREN; STRESS; RESPONSES; ASSOCIATIONS; METAANALYSIS
AB Background: Hyperuricemia predicts the incidence of hypertension in adults and its treatment has blood pressure (BP)-lowering effects in adolescents. To date, no studies have examined the predictive usage of hyperuricemia or urinary uric acid excretion on BP changes in adolescents. Mechanistic models suggest that uric acid impairs both endothelial function and vascular compliance, which would potentially exacerbate a myriad of hypertensive mechanisms, yet little is known about interaction of uric acid and other hypertension risk factors.
   Materials and Methods: The primary study was aimed at the effects of stress on BP in adolescents. A community sample of 84 low-income, urban adolescents (50% male, 95% African American, mean age = 13.36 +/- 1 years) was recruited from public schools. Youth completed a 12-hour (overnight) urine collection at home and their BP was measured during rest and in response to acute psychosocial stress. Seventy-six of the adolescents participated in a follow-up visit at 1.5 years when their resting BP was reassessed. In this substudy, we assessed the relationship of renal urate excretion and BP reactivity.
   Results: After adjusting for resting BP levels at baseline and other covariates, higher levels of uric acid excretion predicted greater BP reactivity to acute psychosocial stress and higher resting BP at 18 months.
   Conclusions: Urinary excretion of uric acid can serve as an alternative, noninvasive measure of serum uric acid levels that are predictive of BP changes. As hyperuricemia-associated hypertension is treatable, urban adolescents may benefit from routine screening for hyperuricemia or high uric acid excretion.
C1 [Mrug, Sylvie; Morris, Anjana Madan; Reynolds, Nina; Patel, Anita; Hill, Danielle C.] Univ Alabama Birmingham, Dept Psychol, 1720 2nd Ave South,CH 415, Birmingham, AL 35294 USA.
   [Mrug, Michel] Univ Alabama Birmingham, Dept Med, 1720 2nd Ave South, Birmingham, AL 35294 USA.
   [Feig, Daniel I.] Univ Alabama Birmingham, Dept Pediat, 1720 2nd Ave South, Birmingham, AL 35294 USA.
C3 University of Alabama System; University of Alabama Birmingham;
   University of Alabama System; University of Alabama Birmingham;
   University of Alabama System; University of Alabama Birmingham
RP Mrug, S (corresponding author), Univ Alabama Birmingham, Dept Psychol, 1720 2nd Ave South,CH 415, Birmingham, AL 35294 USA.
EM smrug@uab.edu
RI Mrug, Sylvie/JCE-0130-2023
OI Feig, Daniel/0000-0002-0017-6335
FU Otsuka Pharmaceuticals; Genzyme (Sanofi)
FX M.M. received research support from Otsuka Pharmaceuticals and Genzyme
   (Sanofi).
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NR 38
TC 6
Z9 7
U1 0
U2 3
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0002-9629
EI 1538-2990
J9 AM J MED SCI
JI Am. J. Med. Sci.
PD APR
PY 2017
VL 353
IS 4
BP 336
EP 341
DI 10.1016/j.amjms.2017.01.008
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA EW0FK
UT WOS:000402163900005
PM 28317621
DA 2025-06-11
ER

PT J
AU Saif-Elnasr, M
   Ibrahim, IM
   Alkady, MM
AF Saif-Elnasr, Mostafa
   Ibrahim, Iman M.
   Alkady, Manal M.
TI Role of Vitamin D on glycemic control and oxidative stress in type 2
   diabetes mellitus
SO JOURNAL OF RESEARCH IN MEDICAL SCIENCES
LA English
DT Article
DE Glycemic control; oxidative stress; type 2 diabetes mellitus; Vitamin D
ID SERUM 25-HYDROXYVITAMIN D; 1,25-DIHYDROXYVITAMIN D-3; SIGNALING
   PATHWAYS; GLUCOSE-TOLERANCE; HEALTH OUTCOMES; CALCIUM INTAKE;
   IMMUNE-SYSTEM; D DEFICIENCY; LIFE-STYLE; ANTIOXIDANT
AB Background: Vitamin D deficiency may play a key role in the development of impaired glucose tolerance, type 2 diabetes mellitus (T2DM), and metabolic syndrome. Several studies have shown that Vitamin D has an antioxidant property. We aimed to investigate 25-hydroxy Vitamin D (25[ OH] D) levels in patients with T2DM and in nondiabetic healthy controls and to ascertain the impact of 25(OH) D levels on glycemic control and oxidative stress in T2DM patients. Materials and Methods: Thirty male patients with T2DM and twenty age- and socioeconomic status-matched male healthy controls were included in the study. Fasting and postprandial blood sugar and glycated hemoglobin (HbA1c) were measured. Enzyme activity of superoxide dismutase (SOD) and glutathione peroxidase (GPx) was determined by spectrophotometric assay, and serum levels of 25(OH) D were measured using radioimmunoassay. Results: Serum Vitamin D levels were significantly lower in patients with T2DM than healthy controls (P = 0.015). There was a significantly lower GPx activity in patients with T2DM than controls (P = 0.048), but the difference in SOD activity did not reach statistical significance. There was a significant negative correlation between serum Vitamin D levels and HbA1c (P = 0.016), but no statistical correlation was shown between serum Vitamin D levels and GPx and SOD. Conclusion: We conclude that low level of Vitamin D might play a significant role in T2DM pathogenesis. Hence, Vitamin D supplementation may improve glycemic control and oxidative stress in T2DM.
C1 [Saif-Elnasr, Mostafa; Ibrahim, Iman M.; Alkady, Manal M.] Atom Energy Author, Natl Ctr Radiat Res & Technol, Dept Radiat Hlth Res, POB 29, Cairo, Egypt.
C3 Egyptian Knowledge Bank (EKB); National Center for Radiation Research &
   Technology; Egyptian Atomic Energy Authority (EAEA)
RP Saif-Elnasr, M (corresponding author), Atom Energy Author, Natl Ctr Radiat Res & Technol, Dept Radiat Hlth Res, POB 29, Cairo, Egypt.
EM mostafa_saif_elnasr@yahoo.com
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NR 54
TC 31
Z9 36
U1 0
U2 8
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, 400059, INDIA
SN 1735-1995
EI 1735-7136
J9 J RES MED SCI
JI J. Res. Med. Sci.
PD FEB
PY 2017
VL 22
AR 22
DI 10.4103/1735-1995.200278
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA EW9HO
UT WOS:000402828600008
PM 28413419
OA gold, Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Kumashiro, N
   Erion, DM
   Zhang, DY
   Kahn, M
   Beddow, SA
   Chu, X
   Still, CD
   Gerhard, GS
   Han, XL
   Dziura, J
   Petersen, KF
   Samuel, VT
   Shulman, GI
AF Kumashiro, Naoki
   Erion, Derek M.
   Zhang, Dongyan
   Kahn, Mario
   Beddow, Sara A.
   Chu, Xin
   Still, Christopher D.
   Gerhard, Glenn S.
   Han, Xianlin
   Dziura, James
   Petersen, Kitt Falk
   Samuel, Varman T.
   Shulman, Gerald I.
TI Cellular mechanism of insulin resistance in nonalcoholic fatty liver
   disease
SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF
   AMERICA
LA English
DT Article
ID PROTEIN-KINASE-C; ENDOPLASMIC-RETICULUM STRESS; HEPATIC STEATOSIS;
   METABOLIC SYNDROME; CERAMIDE SYNTHESIS; SKELETAL-MUSCLE; OBESE SUBJECTS;
   TISSUE; TRIGLYCERIDE; ACTIVATION
AB Insulin resistance is associated with nonalcoholic fatty liver disease (NAFLD) and is a major factor in the pathogenesis of type 2 diabetes. The development of hepatic insulin resistance has been ascribed to multiple causes, including inflammation, endoplasmic reticulum (ER) stress, and accumulation of hepatocellular lipids in animal models of NAFLD. However, it is unknown whether these same cellular mechanisms link insulin resistance to hepatic steatosis in humans. To examine the cellular mechanisms that link hepatic steatosis to insulin resistance, we comprehensively assessed each of these pathways by using flash-frozen liver biopsies obtained from 37 obese, nondiabetic individuals and correlating key hepatic and plasma markers of inflammation, ER stress, and lipids with the homeostatic model assessment of insulin resistance index. We found that hepatic diacylglycerol (DAG) content in cytoplasmic lipid droplets was the best predictor of insulin resistance (R = 0.80, P < 0.001), and it was responsible for 64% of the variability in insulin sensitivity. Hepatic DAG content was also strongly correlated with activation of hepatic PKCe (R = 0.67, P < 0.001), which impairs insulin signaling. In contrast, there was no significant association between insulin resistance and other putative lipid metabolites or plasma or hepatic markers of inflammation. ER stress markers were only partly correlated with insulin resistance. In conclusion, these data show that hepatic DAG content in lipid droplets is the best predictor of insulin resistance in humans, and they support the hypothesis that NAFLD-associated hepatic insulin resistance is caused by an increase in hepatic DAG content, which results in activation of PKCe.
C1 [Kumashiro, Naoki; Erion, Derek M.; Kahn, Mario; Beddow, Sara A.; Dziura, James; Petersen, Kitt Falk; Samuel, Varman T.; Shulman, Gerald I.] Yale Univ, Sch Med, Dept Internal Med, New Haven, CT 06510 USA.
   [Kumashiro, Naoki; Erion, Derek M.; Zhang, Dongyan; Shulman, Gerald I.] Yale Univ, Sch Med, Howard Hughes Med Inst, New Haven, CT 06510 USA.
   [Erion, Derek M.; Shulman, Gerald I.] Yale Univ, Sch Med, Dept Cellular & Mol Physiol, New Haven, CT 06510 USA.
   [Chu, Xin; Still, Christopher D.; Gerhard, Glenn S.] Weis Ctr Res, Geisinger Clin, Danville, PA 17822 USA.
   [Han, Xianlin] Sanford Burnham Med Res Inst, Diabet & Obes Res Ctr, Orlando, FL 32827 USA.
   [Samuel, Varman T.] Vet Affairs Med Ctr, West Haven, CT 06516 USA.
C3 Yale University; Howard Hughes Medical Institute; Yale University; Yale
   University; Sanford Burnham Prebys Medical Discovery Institute; US
   Department of Veterans Affairs; Veterans Health Administration (VHA); VA
   Connecticut Healthcare System
RP Samuel, VT (corresponding author), Yale Univ, Sch Med, Dept Internal Med, New Haven, CT 06510 USA.
EM varman.samuel@yale.edu; gerald.shulman@yale.edu
RI Shulman, Gerald/P-7176-2019; xin, chu/AAC-5332-2021; Li,
   Xiruo/JAO-5198-2023; Kumashiro, Naoki/AAI-4857-2020
OI Shulman, Gerald/0000-0003-1529-5668
FU US Public Health Service [R24 DK-085638, R01 DK-49230, R01 AG-23686, UL1
   RR-024139]; Manpei Suzuki Diabetes Foundation; American Diabetes
   Association; Veterans Affairs Merit Grant
FX We thank Ralph Jacob Aida Groszmann, and Cathy Zou for their technical
   assistance and all the volunteers for their participation in these
   studies. This research was supported by US Public Health Service Grants
   R24 DK-085638, R01 DK-49230, R01 AG-23686, and UL1 RR-024139, a Manpei
   Suzuki Diabetes Foundation Fellowship (to N.K.), Distinguished Clinical
   Scientist Awards from the American Diabetes Association (to K.F.P. and
   G.I.S.), and a Veterans Affairs Merit Grant (to V.T.S.).
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NR 54
TC 456
Z9 497
U1 2
U2 67
PU NATL ACAD SCIENCES
PI WASHINGTON
PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA
SN 0027-8424
J9 P NATL ACAD SCI USA
JI Proc. Natl. Acad. Sci. U. S. A.
PD SEP 27
PY 2011
VL 108
IS 39
BP 16381
EP 16385
DI 10.1073/pnas.1113359108
PG 5
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 825FB
UT WOS:000295255300052
PM 21930939
OA Green Published
DA 2025-06-11
ER

PT J
AU Turcot, V
   Rouleau, T
   Tsopmo, A
   Germain, N
   Potvin, L
   Nuyt, AM
   Lavoie, JC
AF Turcot, Valerie
   Rouleau, Threse
   Tsopmo, Apollinaire
   Germain, Nathalie
   Potvin, Lena
   Nuyt, Anne-Monique
   Lavoie, Jean-Claude
TI Long-term impact of an antioxidant-deficient neonatal diet on lipid and
   glucose metabolism
SO FREE RADICAL BIOLOGY AND MEDICINE
LA English
DT Article; Proceedings Paper
CT 16th Annual Meeting of the Society-for-Free-Radical-Biology-and-Medicine
CY NOV 18-22, 2009
CL San Francisco, CA
SP Soc Free Rad Biol & Med
DE Oxidative stress; Newborn; Glutathione; Programming; Plasma
   triglycerides; Blood glucose; Energy metabolism; Free radicals
ID ACETYL-COA CARBOXYLASE; GAMMA-GLUTAMYL-TRANSPEPTIDASE;
   PROTEIN-TYROSINE-PHOSPHATASE; GLUTATHIONE-REDUCTASE; OXIDATIVE STRESS;
   PRETERM INFANTS; BLOOD-PRESSURE; GUINEA-PIGS; PARENTERAL MULTIVITAMINS;
   HYPOLIPIDEMIC MECHANISMS
AB Newborn infants are at risk for oxidative stress leading to metabolic syndrome features. Oxidative stress car) be induced by oxidant load Such as oxygen Supplementation, peroxides from intravenous nutrition, or low antioxidant defenses. We hypothesize that a modulation of antioxidant defenses during the neonatal period, without external oxidant challenge, will have a long-term influence oil energy metabolism. Guinea pigs were fed between their third and their seventh day of life a regular chow leading to "mature" antioxidant defenses or a deficient chow leading to lower antioxidant defenses. Between weeks I and 14, the animals were fed regular chow. The hepatic oxidized redox Status Of glutathione associated with the deficient diet (-221 +/- 2 vs -228 +/- 1 mV, p<0.01) was maintained until 14 weeks. At 13-14 weeks, animals fed the deficient diet presented lower plasma TG (479 +/- 57 vs 853 +/- 32 mu M, p<0.01), lower blood glucose (5.8 +/- 0.3 vs 6.9 +/- 0.3 mK p<0.05), and better tolerance to glucose (p<0.05). Blood glucose correlated negatively with the redox status (r(2)=0.47, p<0.01). Low antioxidant defenses during the neonatal period induce a better energy substrate profile associated with an oxidized redox status later in life. These findings suggest being aware of negative consequences when adopting "aggressive" antioxidant therapies in newborn infants. (C) 2009 Published by Elsevier Inc.
C1 [Turcot, Valerie; Rouleau, Threse; Lavoie, Jean-Claude] Univ Montreal, Dept Nutr, CHU St Justine, Fac Med, Montreal, PQ H3T 1C5, Canada.
   [Rouleau, Threse; Germain, Nathalie; Potvin, Lena; Nuyt, Anne-Monique; Lavoie, Jean-Claude] Univ Montreal, Dept Paediat, CHU St Justine, Fac Med, Montreal, PQ H3T 1C5, Canada.
   [Tsopmo, Apollinaire] Carleton Univ, Dept Chem, Ottawa, ON K1S 5B6, Canada.
C3 Universite de Montreal; Centre Hospitalier Universitaire Sainte-Justine;
   Universite de Montreal; Centre Hospitalier Universitaire Sainte-Justine;
   Carleton University
RP Lavoie, JC (corresponding author), Univ Montreal, Dept Nutr, CHU St Justine, Fac Med, Montreal, PQ H3T 1C5, Canada.
EM jean-claude.lavoie@recherche-ste-justine.qc.ca
RI Tsopmo, Apollinaire/AAA-3306-2019; Lavoie, Jean-claude/K-2701-2016
OI Tsopmo, Apollinaire/0000-0002-7062-0833
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NR 73
TC 13
Z9 14
U1 0
U2 3
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0891-5849
EI 1873-4596
J9 FREE RADICAL BIO MED
JI Free Radic. Biol. Med.
PD AUG 1
PY 2009
VL 47
IS 3
BP 275
EP 282
DI 10.1016/j.freeradbiomed.2009.04.026
PG 8
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 464UI
UT WOS:000267532800009
PM 19409486
DA 2025-06-11
ER

PT J
AU Ulug, E
   Pinar, AA
AF Ulug, Elif
   Pinar, Aylin Acikgoz
TI A New Approach to Polycystic Ovary Syndrome and Related Cardio-metabolic
   Risk Factors: Dietary Polyphenols
SO CURRENT NUTRITION REPORTS
LA English
DT Review
DE Polyphenols; PCOS; Cardio-metabolic risk factors; Nutrition
ID SYNDROME RAT MODEL; INSULIN-RESISTANCE; OXIDATIVE STRESS; SYNDROME PCOS;
   SOY ISOFLAVONES; DOUBLE-BLIND; YOUNG-WOMEN; RESVERATROL; CURCUMIN;
   INFLAMMATION
AB Purpose of ReviewPolycystic ovarian syndrome (PCOS) is a common endocrine disease characterized by ovulatory dysfunction, hyperandrogenism, and polycystic ovarian morphology and causing various reproductive, metabolic, cardiovascular, oncological, and psychological complications. Recent meta-analyses and systemic reviews showed that PCOS increases the risk factor for various cardio-metabolic complications like insulin resistance, type II diabetes mellitus, dyslipidemia, metabolic syndrome, hypertension, and endothelial dysfunction. In addition to these, it was suggested that chronic low-grade inflammation and oxidative stress are the underlying mechanisms of PCOS-mediated metabolic consequences and might trigger cardio-metabolic risk in women with PCOS. At this point, there is substantial evidence to suggest that various non-nutrient food components modulate cardio-metabolic health together with inflammation and oxidative stress.Recent FindingsIncreasing the intake of dietary polyphenols might reduce oxidative stress and inflammation and thus alleviate the risk of metabolic, endothelial, and cardiovascular disorders. Nowadays, there are an increasing number of studies related to the effects of dietary polyphenols on PCOS and its accompanying cardio-metabolic disturbances. Currently, there is a cumulative number of studies connected to the effects of dietary polyphenols on PCOS and accompanying cardio-metabolic disturbances. However, there is a lack of knowledge in combining the probable mechanisms of dietary polyphenols on PCOS and related cardio-metabolic consequences.Thus, the effects of dietary polyphenols on PCOS and accompanying cardio-metabolic disturbances need to be discussed and evaluated with underlying mechanisms. Consequently, this review was written to reveal the potential effects of dietary polyphenols on PCOS and related metabolic and cardiovascular risk factors in all their aspects.
C1 [Ulug, Elif; Pinar, Aylin Acikgoz] Hacettepe Univ, Fac Hlth Sci, Dept Nutr & Dietet, TR-06100 Ankara, Turkiye.
C3 Hacettepe University
RP Pinar, AA (corresponding author), Hacettepe Univ, Fac Hlth Sci, Dept Nutr & Dietet, TR-06100 Ankara, Turkiye.
EM aylinn@hacettepe.edu.tr
RI ULUG, Elif/D-2382-2018; Açıkgöz Pınar, Aylin/V-8015-2017
OI ULUG, Elif/0000-0003-4759-892X; Acikgoz Pinar, Aylin/0000-0002-8847-9305
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NR 123
TC 3
Z9 3
U1 2
U2 21
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
EI 2161-3311
J9 CURR NUTR REP
JI Curr. Nutr. Rep.
PD SEP
PY 2023
VL 12
IS 3
BP 508
EP 526
DI 10.1007/s13668-023-00488-7
EA AUG 2023
PG 19
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA P5CF5
UT WOS:001041461000001
PM 37530952
DA 2025-06-11
ER

PT J
AU Nakajima, T
   Tanaka, N
   Li, G
   Hu, R
   Kamijo, Y
   Hara, A
   Aoyama, T
AF Nakajima, Takero
   Tanaka, Naoki
   Li, Gang
   Hu, Rui
   Kamijo, Yuji
   Hara, Atsushi
   Aoyama, Toshifumi
TI Effect of bezafibrate on hepatic oxidative stress: comparison between
   conventional experimental doses and clinically-relevant doses in mice
SO REDOX REPORT
LA English
DT Article
DE bezafibrate; oxidative stress; peroxisome proliferator-activated
   receptor alpha (PPAR alpha)
ID ACTIVATED-RECEPTOR-ALPHA; AMINO-ACID-SEQUENCE; ACYL-COA OXIDASE;
   PPAR-ALPHA; RAT-LIVER; METABOLIC SYNDROME; PEROXISOME PROLIFERATORS;
   SECONDARY PREVENTION; FATTY LIVER; CELL-LINE
AB Several rodent studies have demonstrated that fibrate drugs can activate peroxisome proliferator-activated receptor alpha (PPAR alpha) and increase reactive oxygen species (ROS) production. The persistence of strong PPARa activation is considered to be a possible mechanism related to the adverse effects of these agents in humans. We recently found that bezafibrate-treated mice at clinically-relevant doses (10 mg/kg/day) exhibited similar pharmacokinetics to humans, but were different from previous rodent data (> 50 mg/kg/day). To examine whether clinical doses of bezafibrate do in fact activate PPARa and increase hepatic oxidative stress in mice, we administered bezafibrate to wild-type and Ppara-null mice at high (100 mg/kg/day) or low (10 mg/kg/day) doses and assessed ROS-related pathways in the liver. High-dose bezafibrate increased hepatic lipid peroxides in a PPAR alpha-dependent manner, likely from discordant induction of PPAR alpha-regulated ROS-generating enzymes (acyl-CoA oxidase, cytochrome P450 4A, and NADPH oxidase) and enhancement of mitochondrial beta-oxidation. The treatment also activated protein kinase C and phosphatidylinositol-3-kinase in wild-type mice only, suggesting an association between strong PPARa activation and an altered cell signaling cascade. Meanwhile, low-dose bezafibrate reduced serum/liver triglycerides in both genotypes without activating PPAR alpha or enhancing hepatic oxidative stress. These results may support the safety of bezafibrate treatment at clinically-relevant doses.
C1 [Nakajima, Takero; Tanaka, Naoki; Kamijo, Yuji; Hara, Atsushi; Aoyama, Toshifumi] Shinshu Univ, Dept Metab Regulat, Inst Aging & Adaptat, Grad Sch Med, Matsumoto, Nagano 3908621, Japan.
   [Tanaka, Naoki; Kamijo, Yuji] Shinshu Univ, Dept Internal Med, Sch Med, Matsumoto, Nagano 3908621, Japan.
   [Hu, Rui] Hebei Med Univ, Hosp 2, Shijiazhuang, Peoples R China.
   [Li, Gang] Hebei Prov Peoples Hosp, Cardiac Ctr, Shijiazhuang, Peoples R China.
C3 Shinshu University; Shinshu University; Hebei Medical University
RP Tanaka, N (corresponding author), Shinshu Univ, Dept Metab Regulat, Inst Aging & Adaptat, Grad Sch Med, 3-1-1 Asahi, Matsumoto, Nagano 3908621, Japan.
EM tanakan@mail.nih.gov
RI Hara, Atsushi/B-1127-2008
OI Tanaka, Naoki/0000-0002-3212-3836
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NR 46
TC 13
Z9 15
U1 1
U2 4
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1351-0002
EI 1743-2928
J9 REDOX REP
JI Redox Rep.
PD JUN
PY 2010
VL 15
IS 3
BP 123
EP 130
DI 10.1179/174329210X12650506623807
PG 8
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 619VT
UT WOS:000279459100003
PM 20594415
OA Green Published
DA 2025-06-11
ER

PT J
AU Tadros, TM
   Massaro, JM
   Rosito, GA
   Hoffmann, U
   Vasan, RS
   Larson, MG
   Keaney, JF
   Lipinska, I
   Meigs, JB
   Kathiresan, S
   O'Donnell, CJ
   Fox, CS
   Benjamin, EJ
AF Tadros, Thomas M.
   Massaro, Joseph M.
   Rosito, Guido A.
   Hoffmann, Udo
   Vasan, Ramachandran S.
   Larson, Martin G.
   Keaney, John F., Jr.
   Lipinska, Izabella
   Meigs, James B.
   Kathiresan, Sekar
   O'Donnell, Christopher J.
   Fox, Caroline S.
   Benjamin, Emelia J.
TI Pericardial Fat Volume Correlates With Inflammatory Markers: The
   Framingham Heart Study
SO OBESITY
LA English
DT Article
ID EPICARDIAL ADIPOSE-TISSUE; CORONARY-ARTERY-DISEASE; C-REACTIVE PROTEIN;
   METABOLIC SYNDROME; INSULIN-RESISTANCE; RISK-FACTORS;
   CARDIOVASCULAR-DISEASE; MAJOR DETERMINANT; OXIDATIVE STRESS; VISCERAL
   FAT
AB The objective of this study was to determine whether systemic inflammatory and oxidative stress marker concentrations correlate with pericardial and intrathoracic fat volumes. Participants of the Framingham Offspring Study (n = 1,175, 53% women, mean age 59 +/- 9 years) had pericardial and intrathoracic fat volumes assessed by multidetector computed tomography (MDCT) scans, and provided fasting blood and urine samples to measure concentrations of 14 inflammatory markers: C-reactive protein (CRP), interleukin-6, monocyte chemoattractant protein-1 (MCP-1), CD40 ligand, fibrinogen, intracellular adhesion molecule-1, lipoprotein-associated phospholipase A 2 activity and mass, myeloperoxidase, osteoprotegerin, P-selectin, tumor necrosis factor-a, tumor necrosis factor receptor-2, and urinary isoprostanes. Multivariable linear regression models were used to determine the association of log-transformed inflammatory marker concentrations with fat volumes, using fat volume as the dependent variable. Due to smaller sample sizes, models were rerun after adding urinary isoprostanes (n = 961) and tumor necrosis factor-a (n = 813) to the marker panel. Upon backward elimination, four of the biomarkers correlated positively with each fat depot: CRP (P < 0.0001 for each fat depot), interleukin-6 (P < 0.05 for each fat depot), MCP-1 (P < 0.01 for each fat depot), and urinary isoprostanes (P < 0.01 for pericardial fat; P < 0.001 for intrathoracic fat). Even after adjusting for BMI, waist circumference (WC), and abdominal visceral fat, CRP (P = 0.0001) and urinary isoprostanes (P = 0.02) demonstrated significant positive associations with intrathoracic fat, but not with pericardial fat. Multiple markers of inflammation and oxidative stress correlated with pericardial and intrathoracic fat volumes, extending the known association between regional adiposity and inflammation and oxidative stress.
C1 [Tadros, Thomas M.; Massaro, Joseph M.; Vasan, Ramachandran S.; Larson, Martin G.; O'Donnell, Christopher J.; Fox, Caroline S.; Benjamin, Emelia J.] NHLBI, Framingham Heart Study, Boston, MA USA.
   [Tadros, Thomas M.; Benjamin, Emelia J.] Boston Univ, Sch Med, Div Cardiol, Boston Univ Med Ctr, Boston, MA 02118 USA.
   [Massaro, Joseph M.] Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02118 USA.
   [Rosito, Guido A.; Hoffmann, Udo] Harvard Univ, Sch Med, Dept Radiol, Massachusetts Gen Hosp, Boston, MA 02115 USA.
   [Vasan, Ramachandran S.] Boston Univ, Sch Med, Whitaker Cardiovasc Inst, Div Cardiol, Boston, MA 02118 USA.
   [Vasan, Ramachandran S.] Boston Univ, Sch Med, Whitaker Cardiovasc Inst, Div Prevent Med, Boston, MA 02118 USA.
   [Larson, Martin G.] Boston Univ, Dept Math, Boston, MA 02118 USA.
   [Keaney, John F., Jr.; Lipinska, Izabella] Univ Massachusetts, Sch Med, Div Cardiol, Worcester, MA USA.
   [Meigs, James B.; Benjamin, Emelia J.] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Dept Internal Med, Boston, MA 02115 USA.
   [Kathiresan, Sekar; O'Donnell, Christopher J.] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Div Cardiol, Boston, MA 02115 USA.
   [Fox, Caroline S.] Harvard Univ, Sch Med, Brigham & Womens Hosp, Dept Diabet Endocrinol & Metab, Boston, MA 02115 USA.
   [Benjamin, Emelia J.] Boston Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02118 USA.
C3 National Institutes of Health (NIH) - USA; NIH National Heart Lung &
   Blood Institute (NHLBI); Framingham Heart Study; Boston University;
   Boston University; Harvard University; Harvard University Medical
   Affiliates; Massachusetts General Hospital; Harvard Medical School;
   Boston University; Boston University; Boston University; University of
   Massachusetts System; University of Massachusetts Worcester; Harvard
   University; Harvard University Medical Affiliates; Massachusetts General
   Hospital; Harvard Medical School; Harvard University; Harvard University
   Medical Affiliates; Massachusetts General Hospital; Harvard Medical
   School; Harvard University; Harvard University Medical Affiliates;
   Brigham & Women's Hospital; Harvard Medical School; Boston University
RP Benjamin, EJ (corresponding author), NHLBI, Framingham Heart Study, Boston, MA USA.
EM emelia@bu.edu
RI Meigs, James/P-3927-2019; O'Donnell, Christopher/ABT-1150-2022;
   Kumaresan, Raja Sekar/GQB-0200-2022; Ramachandran, Vasan/Y-2527-2019;
   Benjamin, Emelia/E-7103-2011
OI Larson, Martin/0000-0002-9631-1254; Ramachandran,
   Vasan/0000-0001-7357-5970; Keaney, John/0000-0002-0866-1837; Massaro,
   Joseph/0000-0002-2682-4812; Benjamin, Emelia/0000-0003-4076-2336
FU National Heart, Lung, and Blood Institute [N01-HC-25195]; National
   Institute of Health, National Center for Research Resources
   [RO1-HL076784, RO1-HL064753, R01-AG028321]; General Clinical Research
   Centers [M01-RR-01066]; American Diabetes Association; National
   Institute of Health/National Heart, Lung, and Blood Institute
   [2K24HL04334]; NIDDK [K24 DK080140]
FX Lipoprotein-associated phospholipase A2 activity was measured by
   GlaxoSmithKline and lipoprotein-associated phospholipase A2 mass was
   measured by diaDexus without cost to the Framingham Heart Study. This
   study was funded by the National Heart, Lung, and Blood Institute's
   Framingham Heart Study N01-HC-25195 and by RO1-HL076784, RO1-HL064753,
   and R01-AG028321 (E.J.B), National Institute of Health, National Center
   for Research Resources, General Clinical Research Centers Program (grant
   number M01-RR-01066), and by a Career Development Award from the
   American Diabetes Association (J.B.M.). R. S. V. is partially supported
   by 2K24HL04334 (National Institute of Health/National Heart, Lung, and
   Blood Institute). J.B.M. was supported by NIDDK K24 DK080140.
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NR 39
TC 72
Z9 77
U1 0
U2 1
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 1930-7381
J9 OBESITY
JI Obesity
PD MAY
PY 2010
VL 18
IS 5
BP 1039
EP 1045
DI 10.1038/oby.2009.343
PG 7
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 590OA
UT WOS:000277234800031
PM 19875999
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Sohet, FM
   Neyrinck, AM
   Pachikian, BD
   de Backer, FC
   Bindels, LB
   Niklowitz, P
   Menke, T
   Cani, PD
   Delzenne, NM
AF Sohet, Florence M.
   Neyrinck, Audrey M.
   Pachikian, Barbara D.
   de Backer, Fabienne C.
   Bindels, Laure B.
   Niklowitz, Petra
   Menke, Thomas
   Cani, Patrice D.
   Delzenne, Nathalie M.
TI Coenzyme Q10 supplementation lowers hepatic oxidative stress and
   inflammation associated with diet-induced obesity in mice
SO BIOCHEMICAL PHARMACOLOGY
LA English
DT Article
DE High-fat feeding; Fructose; Coenzyme Q10; Oxidative stress; Inflammation
ID CELL-LINE THP-1; INSULIN-RESISTANCE; HIGH-FAT; METABOLIC SYNDROME;
   HIGH-FRUCTOSE; UNIFYING HYPOTHESIS; NADPH OXIDASE; C57BL/6 MICE;
   WEIGHT-GAIN; TNF-ALPHA
AB Background: Diabetes and obesity are metabolic disorders induced by an excessive dietary intake of fat, usually related to inflammation and oxidative stress.
   Aims: The aim of the study is to investigate the effect of the antioxidant coenzyme Q10 (CoQ10) on hepatic metabolic and inflammatory disorders associated with diet-induced obesity and glucose intolerance.
   Methods: C57b16/j mice were fed for 8 weeks, either a control diet (CT) or a high-fat diet plus 21% fructose in the drinking water (HFF). CoQ10 supplementation was performed in this later condition (HFFQ).
   Results: HFF mice exhibit increased energy consumption, fat mass development, fasting glycaemia and insulinemia and impaired glucose tolerance. HFF treatment promoted the expression of genes involved in reactive oxygen species production (NADPH oxidase), inflammation (CRP, STAMP2) and metabolism (CPT1 alpha) in the liver. CoQ10 supplementation decreased the global hepatic mRNA expression of inflammatory and metabolic stresses markers without changing obesity and tissue lipid peroxides compared to HFF mice. HFF diets paradoxically decreased TBARS (reflecting lipid peroxides) levels in liver, muscle and adipose tissue versus CT group, an effect related to vitamin E content of the diet.
   Conclusion: In conclusion, HFF model promotes glucose intolerance and obesity by a mechanism independent on the level of tissue peroxides. CoQ10 tends to decrease hepatic stress gene expression, independently of any modulation of lipid peroxidation, which is classically considered as its most relevant effect. (C) 2009 Elsevier Inc. All rights reserved.
C1 [Delzenne, Nathalie M.] Catholic Univ Louvain, Louvain Drug Res Inst, Nutr & Metab Res Grp, Unit PMNT, B-1200 Brussels, Belgium.
   [Niklowitz, Petra; Menke, Thomas] Univ Witten Herdecke, Childrens Hosp Datteln, Datteln, Germany.
C3 Universite Catholique Louvain; Witten Herdecke University
RP Delzenne, NM (corresponding author), Catholic Univ Louvain, Louvain Drug Res Inst, Nutr & Metab Res Grp, Unit PMNT, Av E Mounier 73-69, B-1200 Brussels, Belgium.
EM florence.sohet@uclouvain.be; audrey.neyrinck@uclouvain.be;
   barbara.pachikian@uclouvain.be; fabienne.debacker@uclouvain.be;
   laure.bindels@uclouvain.be; pf-niklowitz@web.de;
   t.menke@kinderklinikdatteln.de; patrice.cani@uclouvain.be;
   nathalie.delzenne@uclouvain.be
RI Bindels, Laure/T-7846-2019; Neyrinck, Audrey/AAE-7929-2019; Delzenne,
   Nathalie/AAC-4628-2019; Cani, Patrice D./M-8055-2016
OI Delzenne, Nathalie/0000-0003-2115-6082; Bindels, Laure
   B./0000-0003-3747-3234; Neyrinck, Audrey/0000-0002-9435-3338; Cani,
   Patrice D./0000-0003-2040-2448
FU Kaneka Inc.; Region Wallonne [20]; FNRS Belgium
FX This work was supported by Kaneka Inc. and by the Region Wallonne
   (WalNut 20 Project). P.D. Cani is a Research Associate from the FNRS
   Belgium.
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NR 55
TC 129
Z9 136
U1 0
U2 30
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0006-2952
EI 1873-2968
J9 BIOCHEM PHARMACOL
JI Biochem. Pharmacol.
PD DEC 1
PY 2009
VL 78
IS 11
BP 1391
EP 1400
DI 10.1016/j.bcp.2009.07.008
PG 10
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 510EA
UT WOS:000271069600006
PM 19632207
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Tkác, I
   Molcányiová, A
   Javorsky, M
   Kozárová, M
AF Tkác, I
   Molcányiová, A
   Javorsky, M
   Kozárová, M
TI Fenofibrate treatment reduces circulating conjugated diene level and
   increases glutathione peroxidase activity
SO PHARMACOLOGICAL RESEARCH
LA English
DT Article
DE atherosclerosis risk factors; fenofibrate; dyslipidaemia; oxidative
   stress; LDL oxidation; glutathione peroxidase
ID LOW-DENSITY-LIPOPROTEIN; CORONARY-ARTERY-DISEASE; OXIDIZED LDL; EVENTS;
   CIPROFIBRATE; GEMFIBROZIL; ENDOTHELIUM
AB Aims: Treatment with fibrates showed benefit in randomized trials predominantly in subgroups of patients with dyslipidaemia of metabolic syndrome. Post hoc analyses of these trials show that the effect of fibrates on lipid levels explains only minor part of the treatment benefit. The aim of the present study was to examine effect of fenofibrate on some parameters of oxidative stress.
   Patients and methods: The study group included 20 patients (6 males, 14 females) with combined dyslipidaemia. The average age was 54 10 years. Fenofibrate was given for 8 weeks in the dose of 300 mg daily. Lipid levels and parameters of oxidative stress were measured at baseline and after treatment period.
   Results: Treatment with fenofibrate led to reduction of total cholesterol by 18%, LDL cholesterol and apoB by 17%, triglycerides by 46%, as well as increase of HDL cholesterol level by 10%. Among the measured parameters of oxidative stress, fenofibrate treatment significantly reduced level of circulating conjugated dienes (CD) in average by 42% (p < 0.0001) and also non-significantly reduced the production of malonaldehyde. Fenofibrate treatment led to an increase of the activity of antioxidant enzyme glutathione peroxidase (GPx) by 80% from baseline values (p = 0.001).
   Conclusion: Treatment with fenofibrate significantly reduced the level of conjugated dienes, a measure of LDL oxidation, and increased GPx activity. This finding could at least partially explain beneficial effect of fenofibrate treatment beyond that related to levels of commonly measured lipid parameters. (c) 2005 Elsevier Ltd. All rights reserved.
C1 L Pasteur Teaching Hosp, Dept Internal Med 4, Fac Med, Kosice 04190, Slovakia.
   L Pasteur Teaching Hosp, Dept Clin Biochem, Kosice, Slovakia.
RP L Pasteur Teaching Hosp, Dept Internal Med 4, Fac Med, Rastislavova 43, Kosice 04190, Slovakia.
EM ivantkac@medic.upjs.sk
RI Javorsky, Martin/AAL-6279-2021; Tkac, Ivan/B-7040-2008
OI Javorsky, Martin/0000-0003-2316-5847; Tkac, Ivan/0000-0002-3171-8803;
   Kozarova, Miriam/0000-0001-5596-8965
CR Ahotupa M, 1996, CLIN BIOCHEM, V29, P139, DOI 10.1016/0009-9120(95)02043-8
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NR 21
TC 17
Z9 21
U1 0
U2 1
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 1043-6618
J9 PHARMACOL RES
JI Pharmacol. Res.
PD MAR
PY 2006
VL 53
IS 3
BP 261
EP 264
DI 10.1016/j.phrs.2005.12.002
PG 4
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 022RG
UT WOS:000236072800009
PM 16420979
DA 2025-06-11
ER

PT J
AU Uddandrao, VVS
   Naidu, PB
   Chandrasekaran, P
   Saravanan, G
AF Uddandrao, V. V. Sathibabu
   Brahma Naidu, Parim
   Chandrasekaran, P.
   Saravanan, G.
TI Pathophysiology of obesity-related infertility and its prevention and
   treatment by potential phytotherapeutics
SO INTERNATIONAL JOURNAL OF OBESITY
LA English
DT Review
ID HIGH-FAT DIET; METABOLIC SYNDROME; INSULIN-RESISTANCE; OXIDATIVE STRESS;
   DEVELOPMENTAL COMPETENCE; REPRODUCTIVE DYSFUNCTION; LOW TESTOSTERONE;
   GRANULOSA-CELL; EXPRESSION; FERTILITY
AB BackgroundObesity is a complex multifactorial disease in which the accumulation of excess body fat has adverse health effects, as it can increase the risk of several problems, including infertility, in both men and women. Obesity and infertility have risen together in recent years. Against this background, the present review aims to highlight the impact of obesity on infertility and the underlying pathophysiology of obesity-related infertility (ORI) in men and women, and to provide readers with knowledge of current trends in the effective development of phytotherapeutics for its treatment.MethodsWe thoroughly searched in PubMed, MEDLINE, Scopus, EMBASE, and Google Scholar to find all relevant papers on ORI and the therapeutic effects of phytotherapeutics on ORI in men and women.ResultsThe extensive search of the available literature revealed that obesity affects reproductive function through several complex mechanisms such as hyperlipidaemia, hyperinsulinaemia, hyperandrogenism, increased body mass index, disruption of the hormonal milieu, systemic inflammation, oxidative stress, alterations in epigenetics and dysbiosis. On the other hand, several studies reported that phytotherapeutics has a broad therapeutic spectrum of action by improving sex hormone homeostasis, ovarian dysfunction, menstrual cycle and inhibiting ovarian hyperplasia, as well as down-regulating ovarian apoptosis, inflammation and oxidative stress, and controlling metabolic dysfunction in obese women. Male infertility is also addressed by phytotherapeutics by suppressing lipogenesis, increasing testosterone, 3 beta-HSD and 17 beta-HSD levels, improving sperm parameters and attenuating testicular dyslipidaemia, oxidative stress, inflammation and germ cell apoptosis.ConclusionsIn the present review, we discussed the effects of obesity on reproductive dysfunction in men and women and the underlying pathophysiology of ORI. In addition, the therapeutic effect of phytotherapeutics against ORI was highlighted.
C1 [Uddandrao, V. V. Sathibabu; Chandrasekaran, P.; Saravanan, G.] KS Rangasamy Coll Arts & Sci Autonomous, Ctr Biol Sci, Dept Biochem, Tiruchengode 637215, Tamil Nadu, India.
   [Brahma Naidu, Parim] Natl Anim Resource Facil Biomed Res ICMR NARFBR, Dept Anim Physiol & Biochem, Hyderabad 500078, Telangana, India.
C3 Indian Council of Medical Research (ICMR); ICMR - National Animal
   Resource Facility for Biomedical Research (NARFBR)
RP Uddandrao, VVS (corresponding author), KS Rangasamy Coll Arts & Sci Autonomous, Ctr Biol Sci, Dept Biochem, Tiruchengode 637215, Tamil Nadu, India.
EM sathibabu.u@gmail.com
RI Saravanan, Ganapathy/AAG-4283-2020; PONNUSAMY,
   CHANDRASEKARAN/JPK-8450-2023; Uddandrao, Dr. V. V.
   Sathibabu/AAH-8500-2021
OI P, CHANDRASEKARAN/0000-0001-6460-3933
FU The management of K.S. Rangasamy College of Arts and Science
   (Autonomous), Tiruchengode, Namakkal District, Tamilnadu, and
   India-637215 is acknowledged by the authors for its ongoing support and
   provision of the facilities required for doing research. [India-637215]
FX The management of K.S. Rangasamy College of Arts and Science
   (Autonomous), Tiruchengode, Namakkal District, Tamilnadu, and
   India-637215 is acknowledged by the authors for its ongoing support and
   provision of the facilities required for doing research.
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NR 152
TC 9
Z9 11
U1 8
U2 24
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0307-0565
EI 1476-5497
J9 INT J OBESITY
JI Int. J. Obes.
PD FEB
PY 2024
VL 48
IS 2
BP 147
EP 165
DI 10.1038/s41366-023-01411-4
EA NOV 2023
PG 19
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA KB0M4
UT WOS:001101663100001
PM 37963998
DA 2025-06-11
ER

PT J
AU Pinheiro, IRR
   Melo, MFN
   de Sousa, SV
   Cardoso, BG
   da Silva, TM
   Rangel, LP
   Cortes, VF
   Santos, HD
   Chaves, VE
   Garcia, IJP
   Barbosa, LA
AF Restier Pinheiro, Isadora Reis
   Nunes Melo, Marina Fatima
   de Sousa, Sarah Vivas
   Cardoso, Barbara Gatti
   da Silva, Thais Marques
   Rangel, Luciana Pereira
   Cortes, Vanessa Faria
   Santos, Herica de Lima
   Chaves, Valeria Ernestania
   Pereira Garcia, Israel Jose
   Barbosa, Leandro Augusto
TI Evaluation of the effect of cafeteria diet on the kidney Na,K-ATPase
   activity, and oxidative stress
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Article
DE cafeteria diet; kidneys; membrane lipids; Na; K-ATPase; oxidative stress
ID HIGH-FAT DIET; METABOLIC SYNDROME; SUPEROXIDE ANION; ADIPOSE-TISSUE;
   CHOLESTEROL; ATPASE; RATS; LIVER; EXPRESSION; SUBUNIT
AB In this study, renal tissue, subdivided into the cortex and medulla of Wistar rats subjected to a cafeteria diet (CAF) for 24 days or to normal diet, was used to analyze whether the renal enzyme Na,K-ATPase activity was modified by CAF diet, as well as to analyze the alpha 1 subunit of renal Na,K-ATPase expression levels. The lipid profile of the renal plasma membrane and oxidative stress were verified. In the Na,K-ATPase activity evaluation, no alteration was found, but a significant decrease of 30% in the cortex was detected in the alpha 1 subunit expression of the enzyme. There was a 24% decrease in phospholipids in the cortex of rats submitted to CAF, a 17% increase in cholesterol levels in the cortex, and a 23% decrease in the medulla. Lipid peroxidation was significantly increased in the groups submitted to CAF, both in the cortical region, 29%, and in the medulla, 35%. Also, a reduction of 45% in the glutathione levels was observed in the cortex and medulla with CAF. CAF showed a nearly two-fold increase in glutathione peroxidase (GPX) activity in relation to the control group in the cortex and a 59% increase in the GPx activity in the medulla. In conclusion, although the diet was administered for a short period of time, important results were found, especially those related to the lipid profile and oxidative stress, which may directly affect renal function.
C1 [Restier Pinheiro, Isadora Reis; Nunes Melo, Marina Fatima; de Sousa, Sarah Vivas; Cortes, Vanessa Faria; Santos, Herica de Lima; Pereira Garcia, Israel Jose; Barbosa, Leandro Augusto] Univ Fed Sao Joao del Rei, Lab Bioquim Celular, Campus Ctr Oeste Dona Lindu, Divinopolis, MG, Brazil.
   [Cardoso, Barbara Gatti; da Silva, Thais Marques; Chaves, Valeria Ernestania] Univ Fed Sao Joao del Rei, Lab Fisiol, Campus Ctr Oeste Dona Lindu, Divinopolis, MG, Brazil.
   [Cortes, Vanessa Faria; Santos, Herica de Lima; Pereira Garcia, Israel Jose; Barbosa, Leandro Augusto] Univ Fed Sao Joao del Rei, Lab Bioquim Membranas & ATPases, Campus Ctr Oeste Dona Lindu, Divinopolis, MG, Brazil.
   [Rangel, Luciana Pereira] Univ Fed Rio de Janeiro, Fac Farm, Lab Bioquim Tumoral, Rio De Janeiro, Brazil.
C3 Universidade Federal de Sao Joao del-Rei; Universidade Federal de Sao
   Joao del-Rei; Universidade Federal de Sao Joao del-Rei; Universidade
   Federal do Rio de Janeiro
RP Garcia, IJP; Barbosa, LA (corresponding author), Univ Fed Sao Joao del Rei, Campus Ctr Oeste Dona Lindu, BR-35501296 Divinopolis, MG, Brazil.
EM israelpereiragarcia@hotmail.com; lbarbosa@ufsj.edu.br
RI Cortes, Vanessa/GWC-0392-2022; Silva, Thais/CAJ-5690-2022; Rangel,
   Luciana/E-7861-2018; Chaves, Valéria Ernestânia/HGD-6829-2022; Santos,
   Helio/C-2356-2019; Garcia, Israel/M-9539-2015; Barbosa, Leandro
   A/K-1008-2013
OI Chaves, Valeria Ernestania/0000-0003-4026-8565; Cortes, Vanessa
   Faria/0000-0002-6464-7634; Pereira Rangel, Luciana/0000-0002-6154-0815;
   Barbosa, Leandro A/0000-0002-4631-0130; Garcia, Israel Jose
   Pereira/0000-0002-4972-6561; Silva, Thais/0000-0001-7570-8634
FU Conselho Nacional de Desenvolvimento Cientifico e Tecnologico
   [401914/2016-0]; Fundacao de Amparo a Pesquisa do Estado de Minas Gerais
   [APQ00290-16]; Coordenacao de Aperfeicoamento de Pessoal de Nivel
   Superior [001]
FX Conselho Nacional de Desenvolvimento Cientifico e Tecnologico,
   Grant/Award Number: 401914/2016-0; Fundacao de Amparo a Pesquisa do
   Estado de Minas Gerais, Grant/Award Number: APQ00290-16; Coordenacao de
   Aperfeicoamento de Pessoal de Nivel Superior, Grant/Award Number:
   Finance Code 001
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SN 0730-2312
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PD NOV
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VL 120
IS 11
BP 19052
EP 19063
DI 10.1002/jcb.29228
EA JUL 2019
PG 12
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA IX9JQ
UT WOS:000473941400001
PM 31265167
DA 2025-06-11
ER

PT J
AU Perazza, LR
   Brown-Borg, HM
   Thompson, L
AF Perazza, Lais R.
   Brown-Borg, Holly M.
   Thompson, LaDora, V
TI Physiological Systems in Promoting Frailty
SO COMPREHENSIVE PHYSIOLOGY
LA English
DT Article
ID MESENCHYMAL STEM-CELLS; GROWTH-FACTOR-I; MUSCLE MITOCHONDRIAL-FUNCTION;
   RANDOMIZED CONTROLLED-TRIAL; MULTIPLE CHRONIC CONDITIONS; CU/ZN
   SUPEROXIDE-DISMUTASE; ALL-CAUSE MORTALITY; AGE-RELATED-CHANGES; CHAIN
   AMINO-ACIDS; EXTENDS LIFE-SPAN
AB Frailty is a complex syndrome affecting a growing sector of the global population as medical developments have advanced human mortality rates across the world. Our current understanding of frailty is derived from studies conducted in the laboratory as well as the clinic, which have gen-erated largely phenotypic information. Far fewer studies have uncovered biological underpinnings driving the onset and progression of frailty, but the stage is set to advance the field with preclinical and clinical assessment tools, multiomics approaches together with physiological and biochemical methodologies. In this article, we provide comprehensive coverage of topics regarding frailty assessment, preclinical models, interventions, and challenges as well as clinical frameworks and prevalence. We also identify central biological mechanisms that may be at play including mito-chondrial dysfunction, epigenetic alterations, and oxidative stress that in turn, affect metabolism, stress responses, and endocrine and neuromuscular systems. We review the role of metabolic syndrome, insulin resistance and visceral obesity, focusing on glucose homeostasis, adenosine monophosphate-activated protein kinase (AMPK), mammalian target of rapamycin (mTOR), and nicotinamide adenine dinucleotide (NAD+) as critical players influencing the age-related loss of health. We further focus on how immunometabolic dysfunction associates with oxidative stress in promoting sarcopenia, a key contributor to slowness, weakness, and fatigue. We explore the bio-logical mechanisms involved in stem cell exhaustion that affect regeneration and may contribute to the frailty-associated decline in resilience and adaptation to stress. Together, an overview of the interplay of aging biology with genetic, lifestyle, and environmental factors that contribute to frailty, as well as potential therapeutic targets to lower risk and slow the progression of ongoing disease is covered.
C1 [Perazza, Lais R.; Thompson, LaDora, V] Boston Univ, Dept Phys Therapy & Athlet Training, Boston, MA 02215 USA.
   [Brown-Borg, Holly M.] Univ North Dakota, Dept Biomed Sci, Grand Forks, ND USA.
C3 Boston University; University of North Dakota Grand Forks
RP Thompson, L (corresponding author), Boston Univ, Dept Phys Therapy & Athlet Training, Boston, MA 02215 USA.
RI Brown-Borg, Holly/IQV-8650-2023
FU Travis Roy Endowed Professorship; National Instituteon Aging [R56
   AG-067724, K07 AG-072124]
FX This work is supported, in part, by the Travis Roy Endowed Professorship
   (to L.V. Thompson) and the National Instituteon Aging (R56 AG-067724 to
   L.V. Thompson and H. Brown-Borg) and (K07 AG-072124 to L.V. Thompson.
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NR 652
TC 21
Z9 24
U1 0
U2 13
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 2040-4603
J9 COMPR PHYSIOL
JI Compr. Physiol.
PD JUL
PY 2022
VL 12
IS 3
BP 3575
EP 3620
DI 10.1002/cphy.c210034
PG 46
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA A0DG5
UT WOS:000951912300007
PM 35578945
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Ribeiro, ACAF
   Batista, TH
   Ferrari, MS
   Giusti-Paiva, A
   Vilela, FC
AF Ribeiro, Ana Claudia A. F.
   Batista, Tatiane H.
   Ferrari, Mariela S.
   Giusti-Paiva, Alexandre
   Vilela, Fabiana C.
TI The accentuation in post-traumatic stress disorder-like symptoms induced
   by diabetes in rats is not associated with a further increase in
   astrocyte activation in the hippocampus
SO NEUROSCIENCE LETTERS
LA English
DT Article
DE Alloxan; Footshocks; PTSD; GFAP
ID DEPRESSIVE-LIKE BEHAVIOR; ACIDIC PROTEIN GFAP; METABOLIC SYNDROME;
   ALLOXAN; BRAIN; EXTRACT; PEOPLE; FEAR
AB Individuals with post-traumatic stress disorder (PTSD) show increased rates of several serious metabolic diseases. However, little is known about pre-existing metabolic diseases and the development of PTSD. Therefore, we aimed to evaluate the course of post-traumatic stress disorder (PTSD) development in rats with preexisting diabetes. In addition, we quantified glial fibrillary acidic protein (GFAP) in the hippocampus of the experimental animals. For this, we used male Wistar rats and divided them into two groups: saline and alloxan (150 mg/Kg, i. p.). The animals were weighed, and plasma glucose was measured after 48 h of diabetes induction by alloxan. The animals were either exposed to inescapable footshocks or not, followed by social isolation. After 14 days, the animals were re-exposed to the box, and the freezing time was evaluated for 10 min. Over the following days, the animals were tested on the open field, social interaction and forced swimming tests. In another group of animals, elevated plus maze and object recognition tests were performed. Our results demonstrated that animals with diabetes had more pronounced PTSD-like symptoms as a reduction in social interaction, an increase in immobility time in forced swimming, a reduction in permanence in the open arms of the elevated plus maze, and a deficit in the object recognition index more accentuated. However, this did not reflect astrocyte activation in the hippocampus. In conclusion, diabetes accentuates post-traumatic stress disorder-like symptoms but not astrocyte activation in the hippocampus.
C1 [Ribeiro, Ana Claudia A. F.; Giusti-Paiva, Alexandre; Vilela, Fabiana C.] Univ Fed Alfenas Unifal MG, Programa Posgrad Biociencias Aplicadas Saude, Alfenas, Brazil.
   [Ribeiro, Ana Claudia A. F.; Batista, Tatiane H.; Ferrari, Mariela S.; Giusti-Paiva, Alexandre; Vilela, Fabiana C.] Univ Fed Alfenas Unifal MG, Inst Ciencias Biomed, Alfenas, Brazil.
C3 Universidade Federal de Alfenas; Universidade Federal de Alfenas
RP Vilela, FC (corresponding author), Univ Fed Alfenas, Inst Ciencias Biomed, UNIFAL, Ave Jovino Fernandes Sales 2600, BR-37130000 Alfenas, MG, Brazil.
EM fabiana.cardoso@unifal-edu.mg.br
RI Giusti-Paiva, Alexandre/F-3531-2010
OI Solda Ferrari, Mariela/0000-0003-4736-0970; Vilela,
   Fabiana/0000-0001-8691-3748
FU Fundacao de Amparo a Pesquisa de Minas Gerais (FAPEMIG) [03346-18];
   Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
   [429035/2018-7, 311709/2018-4]
FX This work was supported by Fundacao de Amparo a Pesquisa de Minas Gerais
   (FAPEMIG #03346-18, AG-P) and Conselho Nacional de Desenvolvimento
   Cientifico e Tecnologico (CNPq, #429035/2018-7 and #311709/2018-4; FCV).
   The FAPEMIG and CNPq had no further role in the design of the study; the
   collection, analysis, and interpretation of the data; the writing of the
   report; or the decision to submit the paper for publication.
CR Abuelgassim Abuelgassim O, 2013, Pak J Biol Sci, V16, P1398, DOI 10.3923/pjbs.2013.1398.1402
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NR 35
TC 8
Z9 8
U1 0
U2 4
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0304-3940
EI 1872-7972
J9 NEUROSCI LETT
JI Neurosci. Lett.
PD SEP 25
PY 2021
VL 762
AR 136174
DI 10.1016/j.neulet.2021.136174
EA AUG 2021
PG 8
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA UD7RD
UT WOS:000687401300003
PM 34400287
DA 2025-06-11
ER

PT J
AU Campana, G
   Loizzo, S
   Fortuna, A
   Rimondini, R
   Maroccia, Z
   Scillitani, A
   Falchetti, A
   Spampinato, SM
   Persani, L
   Chiodini, I
AF Campana, Gabriele
   Loizzo, Stefano
   Fortuna, Andrea
   Rimondini, Roberto
   Maroccia, Zaira
   Scillitani, Alfredo
   Falchetti, Alberto
   Spampinato, Santi Mario
   Persani, Luca
   Chiodini, Iacopo
TI Early post-natal life stress induces permanent
   adrenocorticotropin-dependent hypercortisolism in male mice
SO ENDOCRINE
LA English
DT Article
DE Cushing&#8217; s syndrome; Pituitary ACTH hypersecretion; Metabolic
   syndrome; Early-life stress; Mouse
ID HPA AXIS DYSREGULATION; CUSHINGS-SYNDROME; CORTICOTROPIN; ENDOCRINE;
   DIAGNOSIS; MODEL; HYPOTHALAMUS; PATHOGENESIS; METABOLISM; MECHANISMS
AB Purpose It has been hypothesized that specific early-life stress (ES) procedures on CD-1 male mice produce diabetes-like alterations due to the failure of negative feedback of glucocorticoid hormone in the pituitary. The aim of this study is to investigate the possible mechanism that leads to this pathological model, framing it in a more specific clinical condition. Methods Metabolic and hypothalamic-pituitary-adrenal-related hormones of stressed mice (SM) have been analyzed immediately after stress procedures (21 postnatal days, PND) and after 70 days of a peaceful (unstressed) period (90 PND). These data have been compared to parameters from age-matched controls (CTR), and mice treated during ES procedures with oligonucleotide antisense for pro-opiomelanocortin (AS-POMC). Results At 21 PND, SM presented an increased secretion of hypothalamic CRH and pituitary POMC-derived peptides, as well as higher plasmatic levels of ACTH and corticosterone vs. CTR. At 90 PND, SM showed hyperglycemia, with suppression of hypothalamic CRH, while pituitary and plasmatic ACTH levels, as well as plasma corticosterone, were constantly higher than in CTR. These values are accompanied by a progressive acceleration in gaining total body weight, which became significant vs. CTR at 90 PND together with a higher pituitary weight. Treatment with AS-POMC prevented all hormonal and metabolic alterations observed in SM, both at 21 and 90 PND. Conclusions These findings show that these specific ES procedures affect the negative glucocorticoid feedback in the pituitary, but not in the hypothalamus, suggesting a novel model of ACTH-dependent hypercortisolism that can be prevented by silencing the POMC gene.
C1 [Campana, Gabriele; Spampinato, Santi Mario] Univ Bologna, Dept Pharm & Biotechnol, Via Irnerio 48, I-40126 Bologna, Italy.
   [Loizzo, Stefano; Fortuna, Andrea; Maroccia, Zaira] Ist Super Sanita, Dept Cardiovasc & Endocrine Metab Dis & Aging, Viale Regina Elena 299, I-00161 Rome, Italy.
   [Rimondini, Roberto] Univ Bologna, Dept Med & Clin Sci, Via Irnerio 48, I-40126 Bologna, Italy.
   [Scillitani, Alfredo] Osped Casa Sollievo Sofferenza IRCCS, Endocrinol & Diabetol, Viale Cappuccini 1, I-71013 San Giovanni Rotondo, Italy.
   [Falchetti, Alberto; Persani, Luca; Chiodini, Iacopo] Univ Milan, Dept Clin Sci & Community Hlth, Via Commenda 19, I-20122 Milan, Italy.
   [Falchetti, Alberto; Persani, Luca; Chiodini, Iacopo] IRCCS Ist Auxolog Italiano, Div Endocrine & Metab Dis, Piazzale Brescia 20, I-20149 Milan, Italy.
   [Falchetti, Alberto; Persani, Luca; Chiodini, Iacopo] IRCCS Ist Auxolog Italiano, Lab Endocrine & Metab Res, Piazzale Brescia 20, I-20149 Milan, Italy.
C3 University of Bologna; Istituto Superiore di Sanita (ISS); University of
   Bologna; IRCCS Casa Sollievo Della Sofferenza; University of Milan;
   IRCCS Istituto Auxologico Italiano; IRCCS Istituto Auxologico Italiano
RP Loizzo, S (corresponding author), Ist Super Sanita, Dept Cardiovasc & Endocrine Metab Dis & Aging, Viale Regina Elena 299, I-00161 Rome, Italy.
EM stefano.loizzo@iss.it
RI Iacopo, Chiodini/W-9911-2019; Campana, Gabriele/A-8285-2010; Maroccia,
   Zaira/N-9270-2017; FALCHETTI, ALBERTO/Q-1787-2016; roberto,
   rimondini/B-2500-2010; Persani, Luca/B-6543-2008
OI Maroccia, Zaira/0000-0002-0659-3076; FALCHETTI,
   ALBERTO/0000-0002-6739-4417; roberto, rimondini/0000-0003-4099-513X;
   Persani, Luca/0000-0003-2068-9581; Fortuna, Andrea/0000-0002-0818-7709;
   Loizzo, Stefano/0000-0001-6344-2613
FU Ricerca Corrente funds of IRCCS Istituto Auxologico Italiano
   [05C921_2019]
FX This research did not receive any specific grant from any funding agency
   in the public, commercial, or not-for-profit sector. The research
   activity of A.F., L.P., and I.C. is partially supported by the Ricerca
   Corrente funds of IRCCS Istituto Auxologico Italiano (code:
   05C921_2019).
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NR 49
TC 5
Z9 5
U1 0
U2 3
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1355-008X
EI 1559-0100
J9 ENDOCRINE
JI Endocrine
PD JUL
PY 2021
VL 73
IS 1
BP 186
EP 195
DI 10.1007/s12020-021-02659-4
EA FEB 2021
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA SU2FT
UT WOS:000621695200001
PM 33630246
DA 2025-06-11
ER

PT J
AU Klafke, JZ
   Porto, FG
   Batista, R
   Bochi, GV
   Moresco, RN
   da Luz, PL
   Viecili, PRN
AF Klafke, Jonatas Zeni
   Porto, Fernando Garcez
   Batista, Roselaine
   Bochi, Guilherme Vargas
   Moresco, Rafael Noal
   da Luz, Protasio Lemos
   Nazario Viecili, Paulo Ricardo
TI Association between hypertriglyceridemia and protein oxidation and
   proinflammatory markers in normocholesterolemic and hypercholesterolemic
   individuals
SO CLINICA CHIMICA ACTA
LA English
DT Article
DE Advanced oxidation protein products; High-sensitivity C-reactive
   protein; Ischemia-modified albumin; Nitric oxide
ID ISCHEMIA-MODIFIED ALBUMIN; CORONARY-HEART-DISEASE; REACTIVE OXYGEN;
   NITRIC-OXIDE; ENDOTHELIAL DYSFUNCTION; METABOLIC SYNDROME; STRESS;
   TRIGLYCERIDES; INFLAMMATION; PRODUCTS
AB Background: Although hypercholesterolemia is a well-established risk factor for coronary heart disease, evidence suggests that increased triglyceride (TG) concentrations are also an independent risk factor. TG concentrations >150 mg/dl are observed nearly twice as often in subjects with atherosclerosis. We assessed the association between hypertriglyceridemia and protein oxidation and proinflammatory markers in normocholesterolemic and hypercholesterolemic individuals.
   Methods: We included 127 volunteers enrolled in Cruz Alta, RS, Brazil. The patients were stratified based on total cholesterol and TG concentrations for analysis of associations with inflammation (high-sensitivity C-reactive protein hs-CRP), endothelial dysfunction (nitric oxide NOx) and oxidative stress (advanced oxidation protein products AOPPs; ischemia-modified albumin IMA). Correlations between variables were determined and multiple regression analysis was employed to investigate whether some variables correlate with TG concentrations.
   Results: Hypertriglyceridemia was related to oxidative stress and proinflammatory markers in individuals independent of total cholesterol concentrations. Moreover, the results indicate a stronger association of tested biomarkers with TG concentrations than with total cholesterol. The results indicate a positive correlation between oxidative stress and TG concentrations in the sera of hypercholesterolemia subjects. AOPPs and IMA concentrations were associated with the presence of hypertriglyceridemia in a manner that was independent of age, gender, hypertension and diabetes mellitus disease, smoking habits, sedentary lifestyle, BMI, waist circumference, LDL, HDL and total cholesterol concentrations.
   Conclusions: We speculate that TG concentrations can reflect the enhancement of protein oxidation and proinflammation. (C) 2015 Elsevier B.V. All rights reserved.
C1 [Klafke, Jonatas Zeni; Porto, Fernando Garcez; Nazario Viecili, Paulo Ricardo] Univ Cruz Alta, Programa Posgrad Atencao Integral Saude, BR-98020290 Cruz Alta, RS, Brazil.
   [Klafke, Jonatas Zeni; Porto, Fernando Garcez; Batista, Roselaine; Nazario Viecili, Paulo Ricardo] Inst Cardiol Cruz Alta, Ctr Ensino & Pesquisa, BR-98010110 Cruz Alta, RS, Brazil.
   [Klafke, Jonatas Zeni; Porto, Fernando Garcez; Batista, Roselaine; Nazario Viecili, Paulo Ricardo] Univ Cruz Alta, Grp Multidisciplinar Saude, BR-98020290 Cruz Alta, RS, Brazil.
   [Bochi, Guilherme Vargas; Moresco, Rafael Noal] Univ Fed Santa Maria, Ctr Ciancias Saude, Dept Anal Clin & Toxicol, Lab Bioquim Clin, BR-97105900 Santa Maria, RS, Brazil.
   [da Luz, Protasio Lemos] Univ Sao Paulo, HCFM, Inst Cardiol, InCor, BR-09500900 Sao Paulo, SP, Brazil.
C3 Universidade de Cruz Alta; Universidade de Cruz Alta; Universidade
   Federal de Santa Maria (UFSM); Fundacao Universitaria de Cardiologia;
   Universidade de Sao Paulo
RP Klafke, JZ (corresponding author), Univ Cruz Alta, Programa Posgrad Atencao Integral Saude, Campus Univ Dr Ulysses Guimaraes, BR-98020290 Cruz Alta, RS, Brazil.
EM jonzeni@hotmail.com
RI Porto, Fernando/F-7205-2017; Klafke, Jonatas/G-4821-2015; Moresco,
   Rafael/K-6118-2017
OI Bochi, Guilherme/0000-0003-1871-1356; Da Luz,
   Protasio/0000-0003-2451-5570; Moresco, Rafael/0000-0003-3072-5080
FU Instituto de Cardiologia de Cruz Alta (ICCA); Programa Institucional de
   Bolsas de Iniciacao Cientifica - (PIBIC) - Conselho Nacional de
   Desenvolvimento Cientffico e Tecnologico (CNPq)
FX This study was supported by the Instituto de Cardiologia de Cruz Alta
   (ICCA). Fellowships from the Programa Institucional de Bolsas de
   Iniciacao Cientifica - (PIBIC) - Conselho Nacional de Desenvolvimento
   Cientffico e Tecnologico (CNPq) are also acknowledged.
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NR 73
TC 20
Z9 20
U1 0
U2 8
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0009-8981
EI 1873-3492
J9 CLIN CHIM ACTA
JI Clin. Chim. Acta
PD AUG 25
PY 2015
VL 448
BP 50
EP 57
DI 10.1016/j.cca.2015.06.013
PG 8
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA CQ8OZ
UT WOS:000360869300010
PM 26115893
DA 2025-06-11
ER

PT J
AU Barve, A
   Khor, TO
   Nair, S
   Reuhl, K
   Suh, N
   Reddy, B
   Newmark, H
   Kong, AN
AF Barve, Avantika
   Khor, Tin Oo
   Nair, Sujit
   Reuhl, Kenneth
   Suh, Nanjoo
   Reddy, Bandaru
   Newmark, Harold
   Kong, Ah-Ng
TI γ-Tocopherol-enriched mixed tocopherol diet inhibits prostate
   carcinogenesis in TRAMP mice
SO INTERNATIONAL JOURNAL OF CANCER
LA English
DT Article
DE oxidative stress; Nrf2; antioxidant detoxifying enzymes; prostate cancer
ID GLUTATHIONE-S-TRANSFERASE; ALPHA-TOCOPHEROL; OXIDATIVE STRESS;
   INTRAEPITHELIAL NEOPLASIA; CYCLOOXYGENASE ACTIVITY; EPITHELIAL-CELLS;
   CANCER RISK; NRF2; CHEMOPREVENTION; BENIGN
AB gamma-tocopherol (gamma-T) alone or in combination with alpha-tocopherol has been shown to suppress biomarkers of oxidative stress in asthamatics and human subjects with metabolic syndrome. Oxidative stress has been implicated as a key event in prostate carcinogenesis. Hence, the purpose of this study was to examine the effects of gamma-tocopherol-enriched mixed tocopherol diet on prostate carcinogenesis in a murine prostate cancer model (TRAMP). 8 week old TRAMP males were fed 0.1% gamma-T-enriched mixed tocopherol diet that contained 20-fold higher levels of gamma-tocopherol, and roughly 3-fold higher levels of alpha-tocopherol. The effect of such diet on tumor and PIN development was observed. The expression of phase II detoxifying, antioxidant enzymes and Nrf2 mRNA and protein were determined by RT-PCR, immunohistochemistry and western blotting techniques. Treatment with gamma-T-enriched mixed tocopherols significantly suppressed the incidence of palpable tumor and Prostate Intraepithelial Neoplasia (PIN) development without affecting the expression of the transgene (SV-40). Tumor progression occurred with a significant suppression of antioxidant enzymes such as catalase, superoxide dismutase, glutathione peroxidase, heme-oxygenase-1 and phase II detoxifying enzymes. Treatment with gamma-T-enriched mixed tocopherol diet upregulated the expression of most detoxifying and antioxidant enzymes. Nrf2-a redox sensitive transcription factor known to mediate the expression of phase H detoxifying enzymes, was also significantly upregulated following treatment with gamma-T-enriched mixed tocopherol diet. gamma-T-enriched mixed tocopherols significantly up-regulated the expression of Nrf2 and its related detoxifying and antioxidant enzymes thereby suppressing PIN and tumor development. (C) 2008 Wiley-Liss, Inc.
C1 [Khor, Tin Oo; Kong, Ah-Ng] Rutgers State Univ, Ernest Mario Sch Pharm, Dept Pharmaceut, Piscataway, NJ 08854 USA.
   [Barve, Avantika; Nair, Sujit] Rutgers State Univ, Ernest Mario Sch Pharm, Grad Program Pharmaceut Sci, Piscataway, NJ USA.
   [Reuhl, Kenneth] Rutgers State Univ, Ernest Mario Sch Pharm, Dept Pharmacol & Toxicol, Piscataway, NJ USA.
   [Suh, Nanjoo; Reddy, Bandaru; Newmark, Harold] Rutgers State Univ, Ernest Mario Sch Pharm, Dept Biol Chem, Piscataway, NJ USA.
   [Suh, Nanjoo; Reddy, Bandaru; Newmark, Harold; Kong, Ah-Ng] Rutgers State Univ, Ernest Mario Sch Pharm, Ctr Canc Prevent Res, Piscataway, NJ USA.
C3 Rutgers University System; Rutgers University New Brunswick; Rutgers
   University System; Rutgers University New Brunswick; Rutgers University
   System; Rutgers University New Brunswick; Rutgers University System;
   Rutgers University New Brunswick; Rutgers University System; Rutgers
   University New Brunswick
RP Kong, AN (corresponding author), Rutgers State Univ, Ernest Mario Sch Pharm, Dept Pharmaceut, 160 Frelinghuysen Rd, Piscataway, NJ 08854 USA.
EM kongt@rci.rutgers.edu
RI Kong, Ah-Ng/AAX-2828-2020; Nair, Sujit/C-4096-2015
OI Nair, Sujit/0000-0002-7322-7375
FU NIEHS NIH HHS [P30 ES005022] Funding Source: Medline
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NR 29
TC 100
Z9 112
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0020-7136
EI 1097-0215
J9 INT J CANCER
JI Int. J. Cancer
PD APR 1
PY 2009
VL 124
IS 7
BP 1693
EP 1699
DI 10.1002/ijc.24106
PG 7
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA 413PL
UT WOS:000263804900025
PM 19115203
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Sun, XC
   Morris, KL
   Zemel, MB
AF Sun, Xiaocun
   Morris, Kristin L.
   Zemel, Michael B.
TI Role of Calcitriol and Cortisol on Human Adipocyte Proliferation and
   Oxidative and Inflammatory Stress: A Microarray Study
SO JOURNAL OF NUTRIGENETICS AND NUTRIGENOMICS
LA English
DT Article
DE Apoptotic gene expression; Calcitriol; Calcitriol/cortisone, microarray
   analysis; Cortisol; Gene expression, patterns; Gene expression, unique
   regulation; Human adipocyte proliferation; 11 beta-Hydroxysteroid
   dehydrogenase type 1; Oxidative and inflammatory stress; Real-time PCR
ID 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1; AP2-AGOUTI TRANSGENIC MICE;
   WHITE ADIPOSE-TISSUE; 1-ALPHA,25-DIHYDROXYVITAMIN D-3; METABOLIC
   SYNDROME; DIETARY CALCIUM; DAIRY-PRODUCTS; WEIGHT-LOSS; OBESITY;
   EXPRESSION
AB Dietary calcium inhibits adiposity, and a key underlying mechanism is suppression of calcitriol, which modulates Ca2+ signaling and mitochondrial uncoupling in adipocytes. We demonstrated that calcitriol directly regulates adipocyte 11 beta-HSD-1 expression and cortisol production in human adipocytes in vitro and dietary calcium inhibits visceral adipose tissue 11 beta-HSD-1 expression in mice, indicating an interaction of calcitriol and cortisol in obesity. Consequently, we have evaluated the gene expression profile of human subcutaneous adipocytes treated with calcitriol and/or cortisone. Data analysis demonstrated significant calcitriol modulation of gene expression toward inhibition of the adipocyte apoptosis (e.g., VEGF and STC-2) and promotion of adipocyte proliferation (e.g., IGF-1 and IGF-1R). Calcitriol also up-regulated oxidative stress and inflammatory genes such as NOX-4 and TLR-3. The calcitriol/cortisone combination resulted in significant additional up-regulation of 11 beta-HSD-1 and down-regulation of adiponectin expression, while cortisone exerted little independent effect in the absence of calcitriol. Overall, calcitriol stimulated a pattern of adipocyte gene expression which favored adipocyte proliferation, oxidative and inflammatory stress and visceral adiposity, and these effects were amplified in the presence of cortisone; however, this conclusion must be tempered by the adipocyte source (subcutaneous) and requires confirmation in visceral adipocytes. Copyright (C) 2007 S. Karger AG, Basel
C1 [Zemel, Michael B.] Univ Tennessee, Dept Nutr, Knoxville, TN 37996 USA.
   [Morris, Kristin L.] Mead Johnson Nutr, Evansville, IN USA.
C3 University of Tennessee System; University of Tennessee Knoxville
RP Zemel, MB (corresponding author), Univ Tennessee, Dept Nutr, 1215 W Cumberland Ave,229, Knoxville, TN 37996 USA.
EM mzemel@utk.edu
OI Zemel, Michael/0000-0003-4104-5750; sun, xiaocun/0000-0003-3053-1518
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NR 37
TC 43
Z9 47
U1 0
U2 7
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1661-6499
EI 1661-6758
J9 J NUTRIGENET NUTRIGE
JI J. Nutrigenet. Nutrigenomics
PY 2008
VL 1
IS 1-2
BP 30
EP 48
DI 10.1159/000109873
PG 19
WC Genetics & Heredity; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Genetics & Heredity; Nutrition & Dietetics
GA 493OD
UT WOS:000269745900005
PM 19918113
DA 2025-06-11
ER

PT J
AU Mazzoli, A
   Spagnuolo, MS
   De Palma, F
   Petecca, N
   Di Porzio, A
   Barrella, V
   Troise, AD
   Culurciello, R
   De Pascale, S
   Scaloni, A
   Mauriello, G
   Iossa, S
   Cigliano, L
AF Mazzoli, Arianna
   Spagnuolo, Maria Stefania
   De Palma, Francesca
   Petecca, Natasha
   Di Porzio, Angela
   Barrella, Valentina
   Troise, Antonio Dario
   Culurciello, Rosanna
   De Pascale, Sabrina
   Scaloni, Andrea
   Mauriello, Gianluigi
   Iossa, Susanna
   Cigliano, Luisa
TI Limosilactobacillus reuteri DSM 17938 relieves inflammation, endoplasmic
   reticulum stress, and autophagy in hippocampus of western diet-fed rats
   by modulation of systemic inflammation
SO BIOFACTORS
LA English
DT Article
DE autophagy; brain; cytokines; endoplasmic reticulum stress; inflammation;
   probiotic; western diet
ID BLOOD-BRAIN-BARRIER; ER STRESS; YOUNG
AB The consumption of western diets, high in fats and sugars, is a crucial contributor to brain molecular alterations, cognitive dysfunction and neurodegenerative diseases. Therefore, a mandatory challenge is the individuation of strategies capable of preventing diet-induced impairment of brain physiology. A promising strategy might consist in the administration of probiotics that are known to influence brain function via the gut-brain axis. In this study, we explored whether Limosilactobacillus reuteri DSM 17938 (L. reuteri)-based approach can counteract diet-induced neuroinflammation, endoplasmic reticulum stress (ERS), and autophagy in hippocampus, an area involved in learning and memory, in rat fed a high fat and fructose diet. The western diet induced a microbiota reshaping, but L. reuteri neither modulated this change, nor the plasma levels of short-chain fatty acids. Interestingly, pro-inflammatory signaling pathway activation (increased NFkB phosphorylation, raised amounts of toll-like receptor-4, tumor necrosis factor-alpha, interleukin-6, GFAP, and Haptoglobin), as well as activation of ERS (increased PERK and eif2 alpha phosphorylation, higher C/EBP-homologous protein amounts) and autophagy (increased beclin, P62-sequestosome-1, and LC3 II) was revealed in hippocampus of western diet fed rats. All these hippocampal alterations were prevented by L. reuteri administration, showing for the first time a neuroprotective role of this specific probiotic strain, mainly attributable to its ability to regulate western diet-induced metabolic endotoxemia and systemic inflammation, as decreased levels of lipopolysaccharide, plasma cytokines, and adipokines were also found. Therapeutic strategies based on the use of L. reuteri DSM17938 could be beneficial in reversing metabolic syndrome-mediated brain dysfunction and cognitive decline.
C1 [Mazzoli, Arianna; De Palma, Francesca; Petecca, Natasha; Di Porzio, Angela; Barrella, Valentina; Culurciello, Rosanna; Iossa, Susanna; Cigliano, Luisa] Univ Naples Federico II, Dept Biol, Complesso Univ Monte S Angelo,Edificio 7,Via Cinti, I-80126 Naples, Italy.
   [Spagnuolo, Maria Stefania; Troise, Antonio Dario; De Pascale, Sabrina; Scaloni, Andrea] CNR, Inst Anim Prod Syst Mediterranean Environm, Portici, Italy.
   [Mauriello, Gianluigi] Univ Naples Federico II, Dept Agr Sci, Portici, Italy.
   [Iossa, Susanna] Natl Biodivers Future Ctr, Palermo, Italy.
   [Iossa, Susanna; Cigliano, Luisa] Univ Naples Federico II, Task Force Microbiome Studies, Portici, Italy.
C3 University of Naples Federico II; Consiglio Nazionale delle Ricerche
   (CNR); Istituto Per Il Sistema Produzione Animale In Ambiente
   Mediterraneo (ISPAAM-CNR); University of Naples Federico II; National
   Biodiversity Future Center; University of Naples Federico II
RP Cigliano, L (corresponding author), Univ Naples Federico II, Dept Biol, Complesso Univ Monte S Angelo,Edificio 7,Via Cinti, I-80126 Naples, Italy.
EM luisa.cigliano@unina.it
RI iossa, susanna/O-1625-2016; Cigliano, Luisa/AEL-3260-2022; De Pascale,
   sabrina/HKE-2021-2023; Mauriello, Gianluigi/D-2939-2016; Spagnuolo,
   Maria/B-7661-2015; Troise, Antonio Dario/O-6113-2017
OI DI PORZIO, ANGELA/0000-0003-4614-5267; De Pascale,
   Sabrina/0000-0001-9249-7058; Troise, Antonio Dario/0000-0001-7635-5244
FU University of Naples Federico II - Ricerca Dip 2021/2022
FX The authors thank Dr. Emilia de Santis for skillful management of animal
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NR 56
TC 2
Z9 2
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0951-6433
EI 1872-8081
J9 BIOFACTORS
JI Biofactors
PD NOV
PY 2024
VL 50
IS 6
BP 1236
EP 1250
DI 10.1002/biof.2082
EA MAY 2024
PG 15
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA O8J6U
UT WOS:001231771800001
PM 38801155
OA hybrid
DA 2025-06-11
ER

PT J
AU Paul, P
   Kaul, R
   Abdellatif, B
   Arabi, M
   Upadhyay, R
   Saliba, R
   Sebah, M
   Chaari, A
AF Paul, Pradipta
   Kaul, Ridhima
   Abdellatif, Basma
   Arabi, Maryam
   Upadhyay, Rohit
   Saliba, Reya
   Sebah, Majda
   Chaari, Ali
TI The Promising Role of Microbiome Therapy on Biomarkers of Inflammation
   and Oxidative Stress in Type 2 Diabetes: A Systematic and Narrative
   Review
SO FRONTIERS IN NUTRITION
LA English
DT Review
DE gut microbiome; gastrointestinal microbiota; clinical trial;
   inflammatory markers; dysbiosis; resistant dextrin; Lactobacillus;
   Bifidobacterium
ID C-REACTIVE PROTEIN; PROBIOTIC SOY MILK; DOUBLE-BLIND; GUT MICROBIOTA;
   INSULIN-RESISTANCE; NITRIC-OXIDE; METABOLIC SYNDROME; ANTIOXIDANT
   STATUS; BLOOD-GLUCOSE; SIGNALING PATHWAY
AB Background: One in 10 adults suffer from type 2 diabetes (T2D). The role of the gut microbiome, its homeostasis, and dysbiosis has been investigated with success in the pathogenesis as well as treatment of T2D. There is an increasing volume of literature reporting interventions of pro-, pre-, and synbiotics on T2D patients. Methods: Studies investigating the effect of pro-, pre-, and synbiotics on biomarkers of inflammation and oxidative stress in T2D populations were extracted from databases such as PubMed, Scopus, Web of Science, Embase, and Cochrane from inception to January 2022. Results: From an initial screening of 5,984 hits, 47 clinical studies were included. Both statistically significant and non-significant results have been compiled, analyzed, and discussed. We have found various promising pro-, pre-, and synbiotic formulations. Of these, multistrain/multispecies probiotics are found to be more effective than monostrain interventions. Additionally, our findings show resistant dextrin to be the most promising prebiotic, followed closely by inulin and oligosaccharides. Finally, we report that synbiotics have shown excellent effect on markers of oxidative stress and antioxidant enzymes. We further discuss the role of metabolites in the resulting effects in biomarkers and ultimately pathogenesis of T2D, bring attention toward the ability of such nutraceuticals to have significant role in COVID-19 therapy, and finally discuss few ongoing clinical trials and prospects. Conclusion: Current literature of pro-, pre- and synbiotic administration for T2D therapy is promising and shows many significant results with respect to most markers of inflammation and oxidative stress.
C1 [Paul, Pradipta; Kaul, Ridhima; Abdellatif, Basma] Qatar Fdn, Div Med Educ, Weill Cornell Med Qatar, Educ City, Doha, Qatar.
   [Arabi, Maryam; Sebah, Majda; Chaari, Ali] Qatar Fdn, Div Premed Educ, Weill Cornell Med Qatar, Educ City, Doha, Qatar.
   [Upadhyay, Rohit] Tulane Univ, Sch Med, Dept Med Nephrol & Hypertens, New Orleans, LA USA.
   [Saliba, Reya] Qatar Fdn, Distributed Elib, Weill Cornell Med Qatar, Educ City, Doha, Qatar.
C3 Qatar Foundation (QF); Weill Cornell Medical College Qatar; Qatar
   Foundation (QF); Weill Cornell Medical College Qatar; Tulane University;
   Qatar Foundation (QF); Weill Cornell Medical College Qatar
RP Chaari, A (corresponding author), Qatar Fdn, Div Premed Educ, Weill Cornell Med Qatar, Educ City, Doha, Qatar.
EM alc2023@qatar-med.cornell.edu
RI Saliba, Reya/ABC-4098-2021; Chaari, Ali/AEQ-0174-2022; Paul,
   Pradipta/IQV-7381-2023; Upadhyay, Rohit/A-5854-2015
OI Paul, Pradipta/0000-0001-6283-1596; Kaul, Ridhima/0000-0003-3487-2512;
   Saliba, Reya/0000-0002-8925-5637; Arabi, Maryam/0000-0003-0815-7902;
   chaari, Ali/0000-0003-0171-143X; Upadhyay, Rohit/0000-0003-1859-7784
FU Weill Cornell Medicine Qatar through a Student Research Mentorship
   Program [SRMP-003-04]
FX This research was supported by Weill Cornell Medicine Qatar through a
   Student Research Mentorship Program SRMP-003-04: Identification and
   characterization of biological properties of probiotic content of
   Qatar's dairy products.
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NR 246
TC 12
Z9 12
U1 2
U2 29
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD MAY 25
PY 2022
VL 9
AR 906243
DI 10.3389/fnut.2022.906243
PG 41
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 2D3GC
UT WOS:000811439000001
PM 35711547
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Moghaddam, HS
   Samarghandian, S
   Farkhondeh, T
AF Moghaddam, Heshmat Sepehri
   Samarghandian, Saeed
   Farkhondeh, Tahereh
TI Effect of bisphenol A on blood glucose, lipid profile and oxidative
   stress indices in adult male mice
SO TOXICOLOGY MECHANISMS AND METHODS
LA English
DT Article
DE Adult mice; bisphenol A; lipid profile; oxidative stress indices
ID CARDIOVASCULAR-DISEASE; PERINATAL EXPOSURE; METABOLIC SYNDROME;
   HYPERGLYCEMIA; PARAMETERS; BRAIN; HYPERLIPIDEMIA; MECHANISM; PATHWAYS;
   TISSUE
AB Bisphenol A (BPA), an endocrine-disrupting chemical, has been considered as a possible risk factor for diabetes and its complications. However, the underlying mechanisms of BPA-induced diabetes are not clear. The present study was performed to evaluate the effects of BPA on the hyperglycemia, lipid abnormalities and oxidative stress. In this study, the mice were divided into three groups of six animals each: One group as a control (C) and two other groups which exposed to 0.5 and 2 mg/kg concentrations of BPA. BPA powder was dissolved in sterile extra virgin olive oil and injected intraperitoneally to the tested groups, while the control group only received pure olive oil for 4 weeks. After 4 weeks, the changes of glucose, lipid profile reduced, total protein, glutathione (GSH), malondialdehyde (MDA), total antioxidant status (TAS), catalase (CAT) and super oxide dismutase (SOD) were determined in serum and pancreas. The results indicated that BPA dose-dependently increased the levels of blood glucose, lipid profile and MDA in the tested groups compared with the control group (p<0.001). BPA reduced significantly the levels of HDL-C and GSH in dose-dependent manner (p<0.001). BPA injection increased the levels of MDA and decreased the levels of GSH and TAS, and also the activities of SOD and CAT in the pancreas of exposed mice compared with the control group (p<0.05). In addition, body weight increased in the mice exposed to BPA compare to control animals. These results suggest that BPA exposure might induce hyperglycemia and its complications in adult male mice by induction of oxidative stress.
C1 [Moghaddam, Heshmat Sepehri; Farkhondeh, Tahereh] Payam Noor Univ, Dept Agr, Tehran, Iran.
   [Samarghandian, Saeed] Neyshabur Univ Med Sci, Dept Basic Med Sci, Neyshabur, Iran.
RP Samarghandian, S (corresponding author), Neyshabur Univ Med Sci, Dept Basic Med Sci, Neyshabur, Iran.
EM samarghandians@mums.ac.ir
RI Farkhondeh, Tahereh/Y-2083-2018
OI farkhondeh, tahereh/0000-0002-9579-8339
FU Research Affairs of Mashhad Payame Noor University
FX The authors thank the Research Affairs of Mashhad Payame Noor
   University, for sponsoring this study.
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NR 52
TC 96
Z9 106
U1 2
U2 23
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1537-6516
EI 1537-6524
J9 TOXICOL MECH METHOD
JI Toxicol. Mech. Methods
PY 2015
VL 25
IS 7
BP 507
EP 513
DI 10.3109/15376516.2015.1056395
PG 7
WC Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Toxicology
GA DD3KS
UT WOS:000369821700001
PM 26376105
DA 2025-06-11
ER

PT J
AU Huang, C
   Kogure, M
   Tomata, Y
   Sugawara, Y
   Hozawa, A
   Momma, H
   Tsuji, I
   Nagatomi, R
AF Huang, Cong
   Kogure, Mana
   Tomata, Yasutake
   Sugawara, Yumi
   Hozawa, Atsushi
   Momma, Haruki
   Tsuji, Ichiro
   Nagatomi, Ryoichi
TI Association of serum adiponectin levels and body mass index with
   worsening depressive symptoms in elderly individuals: a 10-year
   longitudinal study
SO AGING & MENTAL HEALTH
LA English
DT Article
DE Adipokine; depression; jolly fat; adiponectin paradox; longitudinal
   study
ID NERVE GROWTH-FACTOR; CORONARY-HEART-DISEASE; METABOLIC SYNDROME;
   DIABETES-MELLITUS; MUSCLE STRENGTH; OLDER-ADULTS; ALL-CAUSE; MORTALITY;
   RISK; PREVALENCE
AB Objectives: Data regarding the association between adiponectin levels and body mass index (BMI) and long-term changes in depressive symptoms are limited and inconsistent. Thus, we investigated whether circulating adiponectin levels and BMI were independently and combinedly correlated to longitudinal changes in depressive symptoms. Methods: This prospective cohort study evaluated 269 elderly Japanese individuals aged >= 70 years who participated in the Tsurugaya Project conducted between 2002 and 2012. A short form of the Geriatric Depression Scale (GDS) was used to assess depressive status. Serum adiponectin levels were measured using an enzyme-linked immunosorbent assay or a latex particle-enhanced turbidimetric immunoassay. BMI was calculated as body weight (kg)/height (m(2)). Results: Multiple linear regression analysis revealed that baseline serum adiponectin levels were positively associated with changes in GDS scores (beta = 0.14, P = 0.035). However, no association was observed after adjusting for BMI (beta = 0.09, P = 0.185). Low BMI was associated with increased GDS scores at the 10-year follow-up (beta = -0.14, P = 0.033). Participants with a combination of high adiponectin levels and low BMI had a 3.3-fold higher risk of worsening depressive symptoms than those with low adiponectin levels and high BMI (odds ratio: 3.35, 95% confidence interval: 1.60-7.00; P = 0.001). Conclusions: This longitudinal study indicated that high serum adiponectin levels and low BMI were both associated with worsening depressive symptoms among older Japanese individuals. Furthermore, the combination of high adiponectin levels and low BMI was associated with worsening depressive symptoms.
C1 [Huang, Cong] Zhejiang Univ, Coll Educ, Dept Sports & Exercise Sci, 148 Tianmushan Rd, Hangzhou, Zhejiang, Peoples R China.
   [Huang, Cong; Nagatomi, Ryoichi] Tohoku Univ, Grad Sch Med, Dept Med & Sci Sports & Exercise, Sendai, Miyagi, Japan.
   [Kogure, Mana; Hozawa, Atsushi] Tohoku Univ, Tohoku Med Megabank Org, Dept Prevent Med & Epidemiol, Sendai, Miyagi, Japan.
   [Tomata, Yasutake; Sugawara, Yumi; Tsuji, Ichiro] Tohoku Univ, Grad Sch Med, Dept Hlth Informat & Publ Hlth, Sendai, Miyagi, Japan.
   [Momma, Haruki; Nagatomi, Ryoichi] Tohoku Univ, Grad Sch Biomed Engn, Div Biomed Engn Hlth & Welf, Sendai, Miyagi, Japan.
C3 Zhejiang University; Tohoku University; Tohoku University; Tohoku
   University; Tohoku University
RP Huang, C (corresponding author), Zhejiang Univ, Coll Educ, Dept Sports & Exercise Sci, 148 Tianmushan Rd, Hangzhou, Zhejiang, Peoples R China.; Huang, C; Nagatomi, R (corresponding author), Tohoku Univ, Grad Sch Med, Dept Med & Sci Sports & Exercise, Sendai, Miyagi, Japan.; Nagatomi, R (corresponding author), Tohoku Univ, Grad Sch Biomed Engn, Div Biomed Engn Hlth & Welf, Sendai, Miyagi, Japan.
EM cohuang@zju.edu.cn; nagatomi@med.tohoku.ac.jp
RI Huang, Cong/N-4401-2019; Nagatomi, Ryoichi/Q-8792-2016
OI Momma, Haruki/0000-0003-1134-0898; Huang, Cong/0000-0002-2307-864X;
   Nagatomi, Ryoichi/0000-0003-3038-7202
FU Ministry of Education, Culture, Sports, Science, and Technology, Japan
   [21689018]; Ministry of Health, Labor, and Welfare, Japan (Health
   Sciences Research Grants for Health Service) [H24-Choju-Ippan-005];
   Center of Innovation Program from the Japan Science and Technology
   Agency; Grants-in-Aid for Scientific Research [21689018] Funding Source:
   KAKEN
FX This work was supported by the Ministry of Education, Culture, Sports,
   Science, and Technology, Japan (Grant-in-Aid for Young Scientists A;
   21689018); and the Ministry of Health, Labor, and Welfare, Japan (Health
   Sciences Research Grants for Health Service; H24-Choju-Ippan-005). In
   addition, this work was partially supported by the Center of Innovation
   Program from the Japan Science and Technology Agency. The funding
   sources had no involvement in study design, data collection and
   analysis, decision to publish, or preparation of the manuscript.
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NR 38
TC 10
Z9 10
U1 0
U2 19
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 1360-7863
EI 1364-6915
J9 AGING MENT HEALTH
JI Aging Ment. Health
PD MAY 3
PY 2020
VL 24
IS 5
BP 725
EP 731
DI 10.1080/13607863.2019.1584877
EA MAR 2019
PG 7
WC Geriatrics & Gerontology; Gerontology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Psychiatry
GA LK5WR
UT WOS:000463265000001
PM 30884953
DA 2025-06-11
ER

PT J
AU Gai, ZB
   Gui, T
   Hiller, C
   Kullak-Ublick, GA
AF Gai, Zhibo
   Gui, Ting
   Hiller, Christian
   Kullak-Ublick, Gerd A.
TI Farnesoid X Receptor Protects against Kidney Injury in Uninephrectomized
   Obese Mice
SO JOURNAL OF BIOLOGICAL CHEMISTRY
LA English
DT Article
ID RENAL LIPID-METABOLISM; ENDOPLASMIC-RETICULUM STRESS;
   DIABETIC-NEPHROPATHY; MITOCHONDRIAL DYSFUNCTION; ACID; FIBROSIS;
   INFLAMMATION; PROGRESSION; ACTIVATION; GLOMERULOSCLEROSIS
AB Activation of the farnesoid X receptor (FXR) has indicated a therapeutic potential for this nuclear bile acid receptor in the prevention of diabetic nephropathy and obesity-induced renal damage. Here, we investigated the protective role of FXR against kidney damage induced by obesity in mice that had undergone uninephrectomy, a model resembling the clinical situation of kidney donation by obese individuals. Mice fed a high-fat diet developed the core features of metabolic syndrome, with subsequent renal lipid accumulation and renal injury, including glomerulosclerosis, interstitial fibrosis, and albuminuria. The effects were accentuated by uninephrectomy. In human renal biopsies, staining of 4-hydroxynonenal (4-HNE), glucose-regulated protein 78 (Grp78), and C/EBP-homologous protein, markers of endoplasmic reticulum stress, was more prominent in the proximal tubules of 15 obese patients compared with 16 non-obese patients. In mice treated with the FXR agonist obeticholic acid, renal injury, renal lipid accumulation, apoptosis, and changes in lipid peroxidation were attenuated. Moreover, disturbed mitochondrial function was ameliorated and the mitochondrial respiratory chain recovered following obeticholic acid treatment. Culturing renal proximal tubular cells with free fatty acid and FXR agonists showed that FXR activation protected cells from free fatty acid-induced oxidative stress and endoplasmic reticulum stress, as denoted by a reduction in the level of reactive oxygen species staining and Grp78 immunostaining, respectively. Several genes involved in glutathione metabolism were induced by FXR activation in the remnant kidney, which was consistent with a decreased glutathione disulfide/glutathione ratio. In summary, FXR activation maintains endogenous glutathione homeostasis and protects the kidney in uninephrectomized mice from obesity-induced injury.
C1 [Gai, Zhibo; Hiller, Christian; Kullak-Ublick, Gerd A.] Univ Zurich, Univ Zurich Hosp, Dept Clin Pharmacol & Toxicol, Ramistr 100, CH-8091 Zurich, Switzerland.
   [Gui, Ting] Inselspital Bern, Dept Nephrol Hypertens & Clin Pharmacol, CH-3010 Bern, Switzerland.
C3 University of Zurich; University Zurich Hospital; University of Bern;
   University Hospital of Bern
RP Kullak-Ublick, GA (corresponding author), Univ Zurich, Univ Zurich Hosp, Dept Clin Pharmacol & Toxicol, Ramistr 100, CH-8091 Zurich, Switzerland.
EM gerd.kullak@usz.ch
RI Gui, Ting/MIP-7941-2025; GAI, ZHIBO/ABE-7650-2020
OI Kullak-Ublick, Gerd A./0000-0002-0757-4408; Gai,
   Zhibo/0000-0003-1673-6541
FU Swiss National Science Foundation [320030-144193]; Swiss National Center
   for Competence in Research NCCR; International Fellowship Program on
   Integrative Kidney Physiology and Pathophysiology (IKPP) [246539]
FX This study was supported by Grant 320030-144193 from the Swiss National
   Science Foundation (to G. K.-U.), a grant from the Swiss National Center
   for Competence in Research NCCR (Kidney.ch), and Grant 246539 from the
   International Fellowship Program on Integrative Kidney Physiology and
   Pathophysiology (IKPP). The authors declare that they have no conflicts
   of interest with the contents of this article.
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NR 52
TC 75
Z9 81
U1 0
U2 18
PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3996 USA
EI 1083-351X
J9 J BIOL CHEM
JI J. Biol. Chem.
PD JAN 29
PY 2016
VL 291
IS 5
BP 2397
EP 2411
DI 10.1074/jbc.M115.694323
PG 15
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA DD0LB
UT WOS:000369610400029
PM 26655953
OA Green Published
DA 2025-06-11
ER

PT J
AU Monickaraj, F
   Aravind, S
   Gokulakrishnan, K
   Sathishkumar, C
   Prabu, P
   Prabu, D
   Mohan, V
   Balasubramanyam, M
AF Monickaraj, Finny
   Aravind, Sankaramoorthy
   Gokulakrishnan, Kuppan
   Sathishkumar, Chandrakumar
   Prabu, Paramasivam
   Prabu, Durai
   Mohan, Viswanathan
   Balasubramanyam, Muthuswamy
TI Accelerated aging as evidenced by increased telomere shortening and
   mitochondrial DNA depletion in patients with type 2 diabetes
SO MOLECULAR AND CELLULAR BIOCHEMISTRY
LA English
DT Article
DE Telomere shortening; mtDNA depletion; Oxidative stress; Type 2 diabetes
ID URBAN-RURAL EPIDEMIOLOGY; INSULIN-RESISTANCE; OXIDATIVE STRESS;
   ENDOTHELIAL DYSFUNCTION; METABOLIC SYNDROME; MISSING LINK; ADIPONECTIN;
   LENGTH; ASSOCIATION; REPAIR
AB Although shortened telomeres were shown associated with several risk factors of diabetes, there is lack of data on their relationship with mitochondrial dysfunction. Therefore, we compared the relationship between telomere length and mitochondrial DNA (mtDNA) content in patients with type 2 diabetes mellitus (T2DM; n = 145) and in subjects with normal glucose tolerance (NGT; n = 145). Subjects were randomly recruited from the Chennai Urban Rural Epidemiology Study. mtDNA content and telomere length were assessed by Real-Time PCR. Malonodialdehyde, a marker of lipid peroxidation was measured by thiobarbituric acid reactive substances (TBARS) using fluorescence methodology. Adiponectin levels were measured by radioimmunoassay. Oxidative stress as determined by lipid peroxidation (TBARS) was significantly (p < 0.001) higher in patients with T2DM compared to NGT subjects. In contrast, the mean telomere length, adiponectin and mtDNA content were significantly (p < 0.001) lower in patients with T2DM compared to NGT subjects. Telomere length was positively correlated with adiponectin, HDL, mtDNA content and good glycemic/lipid control and negatively correlated with adiposity and insulin resistance. On regression analysis, shortened telomeres showed significant association with T2DM even after adjusting for waist circumference, insulin resistance, triglyceride, HDL, adiponectin, mtDNA & TBARS. mtDNA depletion showed significant association with T2DM after adjusting for waist circumference and adiponectin but lost its significance when further adjusted for telomere length, TBARS and insulin resistance. Our study emphasizes the clustering of accelerated aging features viz., shortened telomeres, decreased mtDNA content, hypoadiponectinemia, low HDL, and increased oxidative stress in Asian Indian type 2 diabetes patients.
C1 [Monickaraj, Finny; Aravind, Sankaramoorthy; Gokulakrishnan, Kuppan; Sathishkumar, Chandrakumar; Prabu, Paramasivam; Prabu, Durai; Mohan, Viswanathan; Balasubramanyam, Muthuswamy] Madras Diabet Res Fdn, Dept Cell & Mol Biol, Madras 600086, Tamil Nadu, India.
   [Monickaraj, Finny; Aravind, Sankaramoorthy; Gokulakrishnan, Kuppan; Sathishkumar, Chandrakumar; Prabu, Paramasivam; Prabu, Durai; Mohan, Viswanathan; Balasubramanyam, Muthuswamy] IDF Ctr Educ, Dr Mohans Diabet Special Ctr, WHO Collaborating Ctr Noncommunicable Dis Prevent, Madras 600086, Tamil Nadu, India.
C3 Madras Diabetes Research Foundation
RP Balasubramanyam, M (corresponding author), Madras Diabet Res Fdn, Dept Cell & Mol Biol, Madras 600086, Tamil Nadu, India.
EM balusignal@gmail.com
RI Viswanathan, Mohan/C-2321-2009; GOKULAKRISHNAN, KUPPAN/AAT-3244-2020;
   Prabu, Paramasivam/V-8323-2018; Chandrakumar,
   Sathishkumar/AAM-3149-2020; Prabu, Paramasivam/HPE-3307-2023
OI Chandrakumar, Sathishkumar/0000-0003-2320-050X; Sankaramoorthy,
   Aravind/0009-0001-2989-199X; Mohan, Viswanathan/0000-0001-5038-6210;
   Prabu, Paramasivam/0000-0002-8626-1601; GOKULAKRISHNAN,
   KUPPAN/0000-0003-3167-8239
FU Department of Biotechnology (DBT), New Delhi; Council of Scientific and
   Industrial Research (CSIR), New Delhi
FX Authors thank the Department of Biotechnology (DBT), New Delhi for the
   financial assistance. A senior research fellowship from the Council of
   Scientific and Industrial Research (CSIR), New Delhi is also thankfully
   acknowledged. This is the 123rd publication of CURES (CURES-123).
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NR 63
TC 96
Z9 104
U1 1
U2 18
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0300-8177
EI 1573-4919
J9 MOL CELL BIOCHEM
JI Mol. Cell. Biochem.
PD JUN
PY 2012
VL 365
IS 1-2
BP 343
EP 350
DI 10.1007/s11010-012-1276-0
PG 8
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA 934UO
UT WOS:000303472400036
PM 22411737
DA 2025-06-11
ER

PT J
AU Rajesh, M
   Bátkai, S
   Kechrid, M
   Mukhopadhyay, P
   Lee, WS
   Horváth, B
   Holovac, E
   Cinar, R
   Liaudet, L
   Mackie, K
   Haskó, G
   Pacher, P
AF Rajesh, Mohanraj
   Batkai, Sandor
   Kechrid, Malek
   Mukhopadhyay, Partha
   Lee, Wen-Shin
   Horvath, Bela
   Holovac, Eileen
   Cinar, Resat
   Liaudet, Lucas
   Mackie, Ken
   Hasko, Gyoergy
   Pacher, Pal
TI Cannabinoid 1 Receptor Promotes Cardiac Dysfunction, Oxidative Stress,
   Inflammation, and Fibrosis in Diabetic Cardiomyopathy
SO DIABETES
LA English
DT Article
ID GLYCATION END-PRODUCTS; ENDOCANNABINOID SYSTEM; CELL-DEATH;
   ANGIOTENSIN-II; ENDOTHELIAL-CELLS; BLOCKADE; OBESITY; ACTIVATION;
   COMPLICATIONS; INHIBITION
AB Endocannabinoids and cannabinoid 1 (CB1) receptors have been implicated in cardiac dysfunction, inflammation, and cell death associated with various forms of shock, heart failure, and atherosclerosis, in addition to their recognized role in the development of various cardiovascular risk factors in obesity/metabolic syndrome and diabetes. In this study, we explored the role of CB1 receptors in myocardial dysfunction, inflammation, oxidative/nitrative stress, cell death, and interrelated signaling pathways, using a mouse model of type 1 diabetic cardiomyopathy. Diabetic cardiomyopathy was characterized by increased myocardial endocannabinoid anandamide levels, oxidative/nitrative stress, activation of p38/Jun NH2-terminal kinase (JNK) mitogen-activated protein kinases (MAPKs), enhanced inflammation (tumor necrosis factor-alpha, interleukin-1 beta, cyclooxygenase 2, intracellular adhesion molecule 1, and vascular cell adhesion molecule 1), increased expression of CB1, advanced glycation end product (AGE) and angiotensin II type 1 receptors (receptor for advanced glycation end product [RAGE], angiotensin II receptor type 1 [AT(1)R]), p47(phox) NADPH oxidase subunit, beta-myosin heavy chain isozyme switch, accumulation of AGE, fibrosis, and decreased expression of sarcoplasmic/endoplasmic reticulum Ca2+-ATPase (SERCA2a). Pharmacological inhibition or genetic deletion of CB1 receptors attenuated the diabetes-induced cardiac dysfunction and the above-mentioned pathological alterations. Activation of CBI receptors by endo-cannabinoids may play an important role in the pathogenesis of diabetic cardiomyopathy by facilitating MAPK activation, AT(1)R expression/signaling, AGE accumulation, oxidative/nitrative stress, inflammation, and fibrosis. Conversely, CB1 receptor inhibition may be beneficial in the treatment of diabetic cardiovascular complications. Diabetes 61:716-727, 2012
C1 [Rajesh, Mohanraj; Batkai, Sandor; Kechrid, Malek; Mukhopadhyay, Partha; Lee, Wen-Shin; Horvath, Bela; Holovac, Eileen; Cinar, Resat; Pacher, Pal] NIAAA, Lab Physiol Studies, NIH, Bethesda, MD USA.
   [Batkai, Sandor] Hannover Med Sch, Inst Mol & Translat Therapeut Strategies, D-3000 Hannover, Germany.
   [Liaudet, Lucas] Univ Lausanne Hosp, Dept Intens Care Med, Lausanne, Switzerland.
   [Mackie, Ken] Indiana Univ, Dept Psychol & Brain Sci, Bloomington, IN USA.
   [Hasko, Gyoergy] Univ Med & Dent New Jersey, New Jersey Med Sch, Dept Surg, Newark, NJ 07103 USA.
C3 National Institutes of Health (NIH) - USA; NIH National Institute on
   Alcohol Abuse & Alcoholism (NIAAA); Hannover Medical School; University
   of Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV); Indiana
   University System; Indiana University Bloomington; Rutgers University
   System; Rutgers University New Brunswick; Rutgers University Biomedical
   & Health Sciences
RP Pacher, P (corresponding author), NIAAA, Lab Physiol Studies, NIH, Bethesda, MD USA.
EM pacher@mail.nih.gov
RI MUKHOPADHYAY, PARTHA/G-3890-2010; Cinar, Resat/H-7219-2019; Bátkai,
   Sándor/H-7983-2014; Mohanraj, Rajesh/L-1798-2019; Horvath,
   Bela/A-7368-2009; Liaudet, Lucas/E-1322-2017; CINAR, RESAT/E-5755-2010;
   Pacher, Pal/B-6378-2008; Mackie, Ken/E-3715-2013
OI CINAR, RESAT/0000-0002-8597-7253; Mohanraj, Rajesh/0000-0003-2660-2184;
   Pacher, Pal/0000-0001-7036-8108; Mackie, Ken/0000-0001-8501-6199;
   Mukhopadhyay, Partha/0000-0002-1178-1274
FU NIH/NIAAA; National Office for Research and Technology-Hungarian
   Scientific Research Fund-European [MB08-A80238]; Alexander von Humboldt
   Foundation; European Commission [FP7-CIG-294278]
FX This study was supported by the Intramural Research Program of NIH/NIAAA
   (to P.P.). B.H. was supported by an National Office for Research and
   Technology-Hungarian Scientific Research Fund-European Union 7th
   Framework fellowship (MB08-A80238). S.B. was supported by the Alexander
   von Humboldt Foundation and the European Commission (FP7-CIG-294278).
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NR 50
TC 216
Z9 230
U1 0
U2 40
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0012-1797
J9 DIABETES
JI Diabetes
PD MAR
PY 2012
VL 61
IS 3
BP 716
EP 727
DI 10.2337/db11-0477
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 899FA
UT WOS:000300800600023
PM 22315315
OA Green Submitted, hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Wang, XL
   Yang, ZM
   Xu, X
   Jiang, H
   Cai, C
   Yu, GL
AF Wang, Xueliang
   Yang, Zimei
   Xu, Xu
   Jiang, Hao
   Cai, Chao
   Yu, Guangli
TI Odd-numbered agaro-oligosaccharides alleviate type 2 diabetes mellitus
   and related colonic microbiota dysbiosis in mice
SO CARBOHYDRATE POLYMERS
LA English
DT Article; Proceedings Paper
CT International Conference on Polysaccharides for Nutraceuticals and
   Biomaterials (ICPNB)
CY NOV 01-03, 2019
CL Shenzhen, PEOPLES R CHINA
DE Odd-numbered oligosaccharides from agarose; Type 2 diabetes mellitus;
   Colitis; Colonic microbiota; Oxidative stress; Insulin resistance;
   Lipid-lowering
ID HIGH-FAT DIET; LOW-GRADE INFLAMMATION; GUT MICROBIOTA; METABOLIC
   SYNDROME; AKKERMANSIA-MUCINIPHILA; INSULIN-RESISTANCE; OXIDATIVE STRESS;
   BARRIER FUNCTION; INDUCED COLITIS; BLOOD-GLUCOSE
AB Agaro- and neoagaro-oligosaccharides with even-numbered sugar units possess a variety of biological activities. However, the effects of the odd-numbered oligosaccharides from Gracilaria agarose (OGAOs) on type 2 diabetes mellitus (T2DM) have not been reported. In this study, we aimed to evaluate the effects of OGAOs on anti-T2DM from different aspects. We found that OGAOs treatment could alleviate oxidative stress, inflammation, and the related hyperglycemia, insulin resistance, lipid accumulation, and obesity in high-fat diet (HFD) induced T2DM. Investigation of the underlying mechanism showed that colitis and colonic microbiota dysbiosis in T2DM mice were ameliorated after OGAOs treatment. First, OGAOs increased the expression of ZO-1, occludin, and AMPK, and suppressed the TLR4/MAPK/NF-kappa B pathway in colon indicating that OGAOs enhance intestinal integrity and conduct the anti-apoptosis effects to prevent the invasion of toxins and harmful microorganisms. Moreover, the relative abundance of Akkermansia was significantly upregulated in the gut microbiome of T2DM mice associated with a dramatic decrease of the relative abundance of Helicobacter, which are both beneficial for alleviating colitis and T2DM. In addition, Spearman's correlation analysis indicated that changes in the colonic microbiota could regulate oxidative stress, inflammation, and hyperlipidemia. In summary, the underlying mechanism of OGAOs on alleviating colitis and colonic microbiota dysbiosis in T2DM has been intensively studied, illustrating that OGAOs could be further developed as a potential pharmaceutical agent for T2DM.
C1 [Wang, Xueliang; Yang, Zimei; Xu, Xu; Jiang, Hao; Cai, Chao; Yu, Guangli] Ocean Univ China, Sch Med & Pharm, Shandong Prov Key Lab Glycosci & Glycotechnol, Key Lab Marine Drugs,Minist Educ, Qingdao 266003, Peoples R China.
   [Wang, Xueliang; Yang, Zimei; Xu, Xu; Jiang, Hao; Cai, Chao; Yu, Guangli] Pilot Natl Lab Marine Sci & Technol Qingdao, Lab Marine Drugs & Bioprod, Qingdao 266237, Peoples R China.
C3 Ocean University of China; Ministry of Education - China; Laoshan
   Laboratory
RP Jiang, H; Cai, C; Yu, GL (corresponding author), Ocean Univ China, Sch Med & Pharm, Qingdao 266003, Peoples R China.
EM haojiang@ouc.edu.cn; caic@ouc.edu.cn; glyu@ouc.edu.cn
RI Jiang, Hao/AAL-2019-2020; zhang, chenhong/HCH-9822-2022; Wang,
   Xueliang/AAY-7112-2021
OI Cai, Chao/0000-0003-4377-3989
FU National Natural Science Foundation of China [81991522, 31670811,
   81402982]; National Science and Technology Major Project of China
   [2018ZX09735-004]; NSFCShandong Joint Fund for Marine Science Research
   Centers [U1606403]; Qingdao National Laboratory for Marine Science and
   Technology [2016ASKJ08-2]; Taishan Scholar Project Special Funds
   [TS201511011]; Shandong Provincial Major Science and Technology
   Innovation Project [2018SDKJ0404]; Natural Science Foundation of
   Shandong Province [ZR2017BC007]
FX This work was supported by National Natural Science Foundation of China
   (81991522, 31670811, 81402982), National Science and Technology Major
   Project of China (2018ZX09735-004), NSFCShandong Joint Fund for Marine
   Science Research Centers (U1606403), Qingdao National Laboratory for
   Marine Science and Technology (2016ASKJ08-2), Taishan Scholar Project
   Special Funds (TS201511011), Shandong Provincial Major Science and
   Technology Innovation Project (2018SDKJ0404), Natural Science Foundation
   of Shandong Province (ZR2017BC007).
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NR 105
TC 50
Z9 56
U1 7
U2 96
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0144-8617
EI 1879-1344
J9 CARBOHYD POLYM
JI Carbohydr. Polym.
PD JUL 15
PY 2020
VL 240
AR 116261
DI 10.1016/j.carbpol.2020.116261
PG 15
WC Chemistry, Applied; Chemistry, Organic; Polymer Science
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Chemistry; Polymer Science
GA LT8KA
UT WOS:000537314900040
PM 32475553
DA 2025-06-11
ER

PT J
AU Palmisano, GL
   Innamorati, M
   Vanderlinden, J
AF Palmisano, Giovanni Luca
   Innamorati, Marco
   Vanderlinden, Johan
TI Life adverse experiences in relation with obesity and binge eating
   disorder: A systematic review
SO JOURNAL OF BEHAVIORAL ADDICTIONS
LA English
DT Review
DE trauma; obesity; binge eating disorder
ID CHILDHOOD SEXUAL-ABUSE; POSTTRAUMATIC-STRESS-DISORDER; DISSOCIATIVE
   EXPERIENCES; RISK-FACTORS; METABOLIC SYNDROME; PERCEIVED STRESS;
   TRAUMATIC STRESS; COMMUNITY SAMPLE; ADRENAL AXIS; WOMEN
AB Background and aims: Several studies report a positive association between adverse life experiences and adult obesity. Despite the high comorbidity between binge eating disorder (BED) and obesity, few authors have studied the link between trauma and BED. In this review the association between exposure to adverse life experiences and a risk for the development of obesity and BED in adulthood is explored. Methods: Based on a scientific literature review in Medline, PubMed and PsycInfo databases, the results of 70 studies (N = 306,583 participants) were evaluated including 53 studies on relationship between adverse life experiences and obesity, 7 studies on post-traumatic stress disorder (PTSD) symptoms in relation to obesity, and 10 studies on the association between adverse life experiences and BED. In addition, mediating factors between the association of adverse life experiences, obesity and BED were examined. Results: The majority of studies (87%) report that adverse life experiences are a risk factor for developing obesity and BED. More precisely a positive association between traumatic experiences and obesity and PTSD and obesity were found, respectively, in 85% and 86% of studies. Finally, the great majority of studies (90%) between trauma and the development of BED in adulthood strongly support this association. Meanwhile, different factors mediating between the trauma and obesity link were identified. Discussion and conclusions: Although research data show a strong association between life adverse experiences and the development of obesity and BED, more research is needed to explain this association.
C1 [Palmisano, Giovanni Luca] Univ Bari Aldo Moro, Dept Psychol, Piazza Umberto, I-70121 Bari, BA, Italy.
   [Innamorati, Marco] Univ Roma Tor Vergata, Dept Sci & Technol Educ, Rome, Italy.
   [Vanderlinden, Johan] Univ Psychiat Ctr KU Leuven, Eating Disorders Unit, Leuven, Belgium.
C3 Universita degli Studi di Bari Aldo Moro; University of Rome Tor
   Vergata; KU Leuven
RP Palmisano, GL (corresponding author), Univ Bari Aldo Moro, Dept Psychol, Piazza Umberto, I-70121 Bari, BA, Italy.
EM gianlucapalmisano@yahoo.it
OI Vanderlinden, Johan/0000-0001-5037-1799
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NR 137
TC 114
Z9 133
U1 1
U2 48
PU AKADEMIAI KIADO ZRT
PI BUDAPEST
PA BUDAFOKI UT 187-189-A-3, H-1117 BUDAPEST, HUNGARY
SN 2062-5871
EI 2063-5303
J9 J BEHAV ADDICT
JI J. Behav. Addict.
PD MAR
PY 2016
VL 5
IS 1
BP 11
EP 31
DI 10.1556/2006.5.2016.018
PG 21
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA DH7EN
UT WOS:000372954900002
PM 28092189
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Chen, PC
   Guo, CH
   Tseng, CJ
   Wang, KC
   Liu, PJ
AF Chen, P. -C.
   Guo, C. -H.
   Tseng, C. -J.
   Wang, K. -C.
   Liu, P-J
TI Blood trace minerals concentrations and oxidative stress in patients
   with obstructive sleep apnea
SO JOURNAL OF NUTRITION HEALTH & AGING
LA English
DT Article
DE Trace minerals; oxidative stress; inflammation; obstructive sleep apnea
ID C-REACTIVE PROTEIN; METABOLIC SYNDROME; COGNITIVE DYSFUNCTION;
   INFLAMMATION; SELENIUM; CHILDREN; OBESITY; CELLS; ANTIOXIDANTS; PATHWAYS
AB Obstructive sleep apnea (OSA) is associated with increased oxidative stress. Certain essential trace minerals have shown to play an important role in the maintenance of redox homeostasis. We determined the concentrations of trace minerals in OSA patients and assessed their relationships to OSA severity as indicated by the apnea/hypopnea index (AHI).
   We enrolled 44 patients with newly diagnosed mild to moderate OSA and 20 without OSA. The following parameters were measured: polysomnographic values of nocturnal sleep; plasma trace minerals zinc (Zn), copper (Cu), iron (Fe), and erythrocyte selenium (Se); oxidative stress status; and plasma high-sensitivity C-reactive protein (hs-CRP) and tumor necrosis factor-alpha (TNF-alpha).
   Compared to controls matched for age, gender, and body mass index, OSA patients had lower concentrations of plasma Zn and erythrocyte Se and higher plasma concentrations of Cu and Fe. OSA patients had significantly higher plasma concentrations of hs-CRP, TNF-alpha, and malondialdehyde (MDA), and lower erythrocyte antioxidant enzyme glutathione peroxidase (GPx) and superoxide dismutase activities. Significant differences in all the above parameters were also found in patients with moderate OSA compared to those with mild OSA. Furthermore, AHI values correlated significantly with neck circumference, GPx activity, and MDA, hs-CRP, and TNF-alpha concentrations in OSA patients. AHI values were also negatively associated with concentrations of plasma Zn and erythrocyte Se, but were positively linked to plasma concentrations of Fe and Cu.
   Abnormal concentrations of these trace minerals may reflect oxidative damage and inflammatory response, thus increasing the severity of OSA.
C1 [Chen, P. -C.; Guo, C. -H.] Hung Kuang Univ, Biomed Nutr & Micronutr Labs, Inst Biomed Nutr, Taichung 433, Taiwan.
   [Tseng, C. -J.] Yuan Rung Gen Hosp, Changhua 510, Taiwan.
   [Wang, K. -C.; Liu, P-J] Cheng Ching Hosp, Dept Otolaryngol, Taichung 407, Taiwan.
   [Liu, P-J] Cheng Ching Hosp, Nutr & Naturopath Ctr, Taichung 407, Taiwan.
   [Liu, P-J] Chung Shan Med Univ, Sch Nutr, Taichung 402, Taiwan.
C3 Hungkuang University; Chung Shan Medical University
RP Liu, PJ (corresponding author), Cheng Ching Hosp, Dept Otolaryngol, Taiwan Blvd, Taichung 407, Taiwan.
EM xz48899959@gmail.com
RI Chen, Pau-Chung/H-5686-2011
FU Cheng-Ching Hospital, Taichung, Taiwan
FX Research supported in part by a grant from Cheng-Ching Hospital,
   Taichung, Taiwan.
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NR 44
TC 39
Z9 40
U1 2
U2 15
PU SPRINGER FRANCE
PI PARIS
PA 22 RUE DE PALESTRO, PARIS, 75002, FRANCE
SN 1279-7707
EI 1760-4788
J9 J NUTR HEALTH AGING
JI J. Nutr. Health Aging
PD AUG
PY 2013
VL 17
IS 8
BP 639
EP 644
DI 10.1007/s12603-013-0023-x
PG 6
WC Geriatrics & Gerontology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology; Nutrition & Dietetics
GA 231QM
UT WOS:000325432400001
PM 24097016
OA hybrid
DA 2025-06-11
ER

PT J
AU Conceiçao, EPS
   Franco, JG
   Oliveira, E
   Resende, AC
   Amaral, TAS
   Peixoto-Silva, N
   Passos, MCF
   Moura, EG
   Lisboa, PC
AF Conceicao, Ellen P. S.
   Franco, Juliana G.
   Oliveira, Elaine
   Resende, Angela C.
   Amaral, Taline A. S.
   Peixoto-Silva, Nayara
   Passos, Magna C. F.
   Moura, Egberto G.
   Lisboa, Patricia C.
TI Oxidative stress programming in a rat model of postnatal early
   overnutrition - role of insulin resistance
SO JOURNAL OF NUTRITIONAL BIOCHEMISTRY
LA English
DT Article
DE Small litter; Reactive oxygen species; Insulin signaling
ID FATTY LIVER-DISEASE; METABOLIC SYNDROME; OBESITY; RECEPTOR; ALPHA;
   PATHOGENESIS; DYSFUNCTION; MECHANISMS; OVERWEIGHT; EXPRESSION
AB Postnatal early overfeeding (EO) is related to later development of overweight and other metabolic disorders. As oxidative stress is implicated in most human diseases, as obesity and diabetes, we decided to study some parameters related to oxidative stress and insulin signaling in liver from EO animals in adult life. To induce EO, litter size was reduced to three pups per litter (SL: small litter) and groups with normal litter size (NL:10 pups per litter) were used as control. After weaning, rats had free access to standard diet and water. Body weight and food intake were monitored daily and offspring were killed at 180 days-old. Significant differences had P<.05 or less. As expected, SL rats had hyperphagia, higher body weight and higher visceral fat mass at weaning and adulthood. In liver, postnatal EO programmed for lower catalase (-42%), superoxide dismutase (-45%) and glutathione peroxidase (-65%) activities. The evaluation of liver injury in adult SL group showed lower nitrite content (-10%), higher liver and plasma malondialdehyde content (+25% and 1.1-fold increase, respectively). No changes of total protein bound carbonyl or Cu/Zn superoxide dismutase protein expression in liver were detected between the groups. Regarding insulin signaling pathway in liver, SL offspring showed lower IR beta (-66%), IRS1 (-50%), phospho-IRS1 (-73%), PI3-K (-30%) and Akt1 (-58%). Indeed, morphological analysis showed that SL rats presented focal areas of inflammatory cell infiltrate and lipid drops in their cytoplasm characterizing a microsteatosis. Thus, we evidenced that postnatal EO can program the oxidative stress in liver, maybe contributing for impairment of the insulin signaling. (C) 2013 Elsevier Inc. All rights reserved.
C1 [Conceicao, Ellen P. S.; Franco, Juliana G.; Oliveira, Elaine; Peixoto-Silva, Nayara; Passos, Magna C. F.; Moura, Egberto G.; Lisboa, Patricia C.] Univ Estado Rio De Janeiro, Dept Physiol Sci, Roberto Alcantara Gomes Biol Inst, BR-20551030 Rio De Janeiro, RJ, Brazil.
   [Resende, Angela C.; Amaral, Taline A. S.] Univ Estado Rio De Janeiro, Dept Pharmacol & Psychobiol, BR-20551030 Rio De Janeiro, RJ, Brazil.
C3 Universidade do Estado do Rio de Janeiro; Universidade do Estado do Rio
   de Janeiro
RP Lisboa, PC (corresponding author), Univ Estado Rio de Janeiro, Dept Ciencias Fisiol, Inst Biol, 5 Andar,Av 28 Setembro,87, BR-20550030 Rio De Janeiro, RJ, Brazil.
EM pclisboa@uerj.br
RI Resende, Angela/M-8632-2017; Peixoto-Silva, Nayara/P-5072-2015; Moura,
   Egberto/ABA-6188-2021; Lisboa, Patricia/H-8336-2015; Moura,
   Egberto/H-1270-2012
OI Lisboa, Patricia/0000-0002-2477-4364; Conceicao Furber,
   Ellen/0000-0003-0370-1032; Moura, Egberto/0000-0002-1159-7549
FU "National Council for Scientific and Technological Development"
   (Conselho Nacional de Desenvolvimento Cientifico e Tecnologico-CNPq);
   "Carlos Chagas Filho Research Foundation of the State of Rio de Janeiro"
   (Fundacao Carlos Chagas Filho de Amparo a Pesquisa do Estado do Rio de
   Janeiro-FAPERJ); Coordination for the Enhancement of Higher Education
   Personnel (Coordenacao de Aperfeicoamento de Pessoal de Nivel
   Superior-CAPES)
FX Funding: This research was supported by the "National Council for
   Scientific and Technological Development" (Conselho Nacional de
   Desenvolvimento Cientifico e Tecnologico-CNPq), the "Carlos Chagas Filho
   Research Foundation of the State of Rio de Janeiro" (Fundacao Carlos
   Chagas Filho de Amparo a Pesquisa do Estado do Rio de Janeiro-FAPERJ)
   and Coordination for the Enhancement of Higher Education Personnel
   (Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior-CAPES).
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NR 55
TC 54
Z9 58
U1 0
U2 19
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0955-2863
EI 1873-4847
J9 J NUTR BIOCHEM
JI J. Nutr. Biochem.
PD JAN
PY 2013
VL 24
IS 1
BP 81
EP 87
DI 10.1016/j.jnutbio.2012.02.010
PG 7
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA 056HT
UT WOS:000312479700011
PM 22819562
DA 2025-06-11
ER

PT J
AU McCarty, MF
AF McCarty, Mark F.
TI Full-spectrum antioxidant therapy featuring astaxanthin coupled with
   lipoprivic strategies and salsalate for management of non-alcoholic
   fatty liver disease
SO MEDICAL HYPOTHESES
LA English
DT Article
ID ACTIVATED PROTEIN-KINASE; HEPATIC STELLATE CELLS; NF-KAPPA-B;
   ALPHA-LIPOIC ACID; INSULIN-RECEPTOR SUBSTRATE-1; PLACEBO-CONTROLLED
   TRIAL; NECROSIS-FACTOR-ALPHA; NADPH OXIDASE; OXIDATIVE STRESS; VITAMIN-E
AB Owing to the worldwide epidemic of obesity, and the popularity of diets rich in sugar and saturated fat, nonalcoholic fatty liver disease (NAFLD) is increasingly common; it is usually associated with insulin resistance, and may be considered a component of the metabolic syndrome. The pathologies which can complicate hepatic steatosis - steatohepatitis, cirrhosis, and hepatic cancer - appear to result from an interaction of hepatic lipid overload and hepatic oxidative stress. It is therefore proposed that comprehensive regimens which effectively target each of these precipitating factors should achieve the best therapeutic benefit in NAFLD. Appropriate weight loss, and a diet low in saturated fat, glycemic index, and added sugars, should decrease hepatic lipid load. Measures which enhance adipocyte insulin sensitivity - such as pioglitazone, astaxanthin, and spirulina - may also be helpful in this regard, as may agents that boost hepatocyte capacity for fatty acid oxidation, such as metformin, carnitine, hydroxycitrate, long-chain omega-3 fats, and glycine. Astaxanthin and spirulina appear to have considerable potential for controlling the oxidative stress associated with NAFLD - the former because it may help to prevent the mitochondrial damage that renders mitochondria a key source of superoxide in this syndrome, the latter because it is exceptionally rich in phycocyanobilin, a phytochemical inhibitor of NAPDH oxidase. Other antioxidants which show some promise in this syndrome include high-dose folate, lipoic acid, melatonin, N-acetylcysteine, vitamin E, and taurine. Finally, treatment with salsalate, an inhibitor of IkappaB kinase-beta, has potential for blunting the adverse impact of hepatic steatosis on oxidative stress and inflammation. (C) 2011 Elsevier Ltd. All rights reserved.
C1 NutriGuard Res, Encinitas, CA 92024 USA.
RP McCarty, MF (corresponding author), NutriGuard Res, 1051 Hermes Ave, Encinitas, CA 92024 USA.
EM markfmccarty@gmail.com
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NR 163
TC 27
Z9 27
U1 0
U2 38
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0306-9877
EI 1532-2777
J9 MED HYPOTHESES
JI Med. Hypotheses
PD OCT
PY 2011
VL 77
IS 4
BP 550
EP 556
DI 10.1016/j.mehy.2011.06.029
PG 7
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 827PL
UT WOS:000295440300017
PM 21764223
DA 2025-06-11
ER

PT J
AU Qi, GY
   Mi, YS
   Wang, YW
   Li, RN
   Huang, SX
   Li, XY
   Liu, XB
AF Qi, Guoyuan
   Mi, Yashi
   Wang, Yiwen
   Li, Runnan
   Huang, Shuxian
   Li, Xingyu
   Liu, Xuebo
TI Neuroprotective action of tea polyphenols on oxidative stress-induced
   apoptosis through the activation of the TrkB/CREB/BDNF pathway and
   Keap1/Nrf2 signaling pathway in SH-SY5Y cells and mice brain
SO FOOD & FUNCTION
LA English
DT Article
ID PARKINSONS-DISEASE; METABOLIC SYNDROME; CANCER; IMPAIRMENT; MAPK;
   NEUROENDOCRINE; INVOLVEMENT; KINASE/AKT; PI3K/AKT; GALLATE
AB Many studies have shown that oxidative stress is a major cause of cellular injuries in a variety of human diseases including cognitive impairment. Tea polyphenols (TPs), natural plant flavonoids found in tea plant leaves, possess the bioactivity to affect the pathogenesis of several chronic diseases via antioxidant associated mechanisms. However, the possible antioxidant and neuroprotective properties of TPs in the brain of mice housed in constant darkness and in H2O2-stimulated SH-SY5Y cells are yet to be elucidated. In this study, pretreatment with TPs markedly attenuated H2O2-elicited cell viability loss and mitochondrial dysfunction, suppressed the induced apoptosis and reduced the elevated levels of intracellular ROS and H2O2. Additionally, TPs modulate the nuclear translocation of Nrf2 and the TrkB/CREB/BDNF signaling pathway by provoking the PI3K/AKT pathway and thus, they transcriptionally regulate the downstream expression of antioxidant enzymes including HO-1, NQO-1, and BDNF in SH-SY5Y cells. Furthermore, an in vivo study revealed that housing mice in constant darkness, simulating shift work disruption in humans, notably affects the AKT/CREB/BDNF signal pathway and the nuclear translocation of Nrf2 and its downstream phase II detoxification enzymes in brain tissue. Remarkably, TP supplementation through drinking water eliminated these changes. These results suggest that TPs possess protective effects against oxidative stress-triggered cognitive impairment, which might be a potential nutritional preventive strategy for neurodegenerative diseases implicated with oxidative stress in shift workers.
C1 [Qi, Guoyuan; Mi, Yashi; Wang, Yiwen; Li, Runnan; Huang, Shuxian; Li, Xingyu; Liu, Xuebo] Northwest A&F Univ, Coll Food Sci & Engn, Lab Funct Chem & Nutr Food, Yangling 712100, Shaanxi, Peoples R China.
C3 Northwest A&F University - China
RP Liu, XB (corresponding author), Northwest A&F Univ, Coll Food Sci & Engn, Lab Funct Chem & Nutr Food, Yangling 712100, Shaanxi, Peoples R China.
EM xueboliu@aliyun.com
RI /AAZ-9695-2020
OI Li., Runnan/0009-0007-6655-2325
FU National Natural Science Foundation of China [31571842]; National Key
   Research and Development Program of China [2016YFD0400601]
FX This work was financially supported by the National Natural Science
   Foundation of China (No. 31571842) and the National Key Research and
   Development Program of China (No. 2016YFD0400601).
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NR 55
TC 85
Z9 87
U1 1
U2 54
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PD DEC
PY 2017
VL 8
IS 12
BP 4421
EP 4432
DI 10.1039/c7fo00991g
PG 12
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA FQ1SC
UT WOS:000418136900015
PM 29090295
DA 2025-06-11
ER

PT J
AU Wilcox, CS
AF Wilcox, Christopher S.
TI Effects of tempol and redox-cycling nitroxides in models of oxidative
   stress
SO PHARMACOLOGY & THERAPEUTICS
LA English
DT Review
DE Reactive oxygen species; Oxidative stress; Blood vessels; Kidney; Heart;
   Brain
ID PERMEABLE RADICAL SCAVENGER; NITRIC-OXIDE SYNTHASE; SPONTANEOUSLY
   HYPERTENSIVE-RAT; RENIN-ANGIOTENSIN SYSTEM; SMOOTH-MUSCLE-CELLS;
   ATM-DEFICIENT MICE; NF-KAPPA-B; ISCHEMIA-REPERFUSION INJURY;
   SUPEROXIDE-DISMUTASE GENE; ACTIVATED PROTEIN-KINASE
AB Tempol is a redox-cycling nitroxide that promotes the metabolism of many reactive oxygen species (ROS) and improves nitric oxide bioavailability. It has been studied extensively in animal models of oxidative stress. Tempol has been shown to preserve mitochondria against oxidative damage and improve tissue oxygenation. Tempol improved insulin responsiveness in models of diabetes mellitus and improved the dyslipidemia, reduced the weight gain and prevented diastolic dysfunction and heart failure in fat-fed models of the metabolic syndrome. Tempol protected many organs, including the heart and brain, from ischemia/reperfusion damage. Tempo! prevented podocyte damage, glomerulosclerosis. proteinuria and progressive loss of renal function in models of salt and mineralocorticosteroid excess. It reduced brain or spinal cord damage after ischemia or trauma and exerted a spinal analgesic action. Tempol improved survival in several models of shock. It protected normal cells from radiation while maintaining radiation sensitivity of tumor cells. Its paradoxical pro-oxidant action in tumor cells accounted for a reduction in spontaneous tumor formation. Tempol was effective in some models of neurodegeneration. Thus, tempol has been effective in preventing several of the adverse consequences of oxidative stress and inflammation that underlie radiation damage and many of the diseases associated with aging. Indeed, tempol given from birth prolonged the life span of normal mice. However, presently tempol has been used only in human subjects as a topical agent to prevent radiation-induced alopecia. (C) 2010 Elsevier Inc. All rights reserved.
C1 [Wilcox, Christopher S.] Georgetown Univ, Div Nephrol & Hypertens, Med Ctr, Dept Med, Washington, DC 20007 USA.
   [Wilcox, Christopher S.] Georgetown Univ, Ctr Hypertens Kidney & Vasc Hlth, Washington, DC 20007 USA.
C3 Georgetown University; Georgetown University
RP Wilcox, CS (corresponding author), Georgetown Univ, Div Nephrol & Hypertens, Med Ctr, Dept Med, 6 PHC,Suite F6003,3800 Reservoir Rd,NW, Washington, DC 20007 USA.
EM wilcoxch@georgetown.edu
FU NIDDK [DK-049870, DK-036079]; NHLBI [HL-68686]
FX Work in the author's laboratory is supported by grants from the NIDDK
   (DK-049870 and DK-036079) and the NHLBI (HL-68686), by funds from the
   George E. Schreiner Chair of Nephrology and the Georgetown University
   Hypertension, Kidney and Vascular Disease Center.
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NR 501
TC 380
Z9 412
U1 0
U2 78
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0163-7258
J9 PHARMACOL THERAPEUT
JI Pharmacol. Ther.
PD MAY
PY 2010
VL 126
IS 2
BP 119
EP 145
DI 10.1016/j.pharmthera.2010.01.003
PG 27
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 594QK
UT WOS:000277552100002
PM 20153367
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Kumar, M
   Maqbool, S
AF Kumar, Manish
   Maqbool, Shahnawaz
TI Memory improvement by modafinil at cost of metabolic hazards? A study to
   decipher the benefits and risks of modafinil in rats
SO NEUROTOXICOLOGY
LA English
DT Article
DE Type-2 diabetes; Modafinil; Memory; Acetylcholinesterase; Serum lipid;
   Oxidative stress
ID GLUCOSE-METABOLISM; SLEEP LOSS; OBESITY; SERUM; DEFICITS; ENHANCER;
   RELEASE; SYSTEM; IMPACT; MODEL
AB Background: Modafinil is approved for narcolepsy and achieved high success in off-label indications in memory-related disorders. However, chronic indiscriminate use of modafinil imposes several health hazards like hyperglycaemia, obesity and metabolic syndrome, owing to impairment of sleep-wake cycle, circadian-rhythm, and neurotransmission. The present protocol elucidates the effects of modafinil per se and diabetic complications apropos.
   Methods: Modafinil (100 and 200 mg/kg) was administered in rats from day 5-26. To induce type-2 diabetes, streptozotocin (STZ) was given on day 1, and blood glucose assessed on day 5. CPP (combination propranolol and phentolamine) was administered to antagonize sympathetic activity. After evaluation of cognitive functions, serum lipid profile, and biomarkers of oxidative stress and acetylcholinesterase (AChE) activity were assessed.
   Results: Subacute dosing of modafinil significantly elevated blood glucose levels, albeit considerably less than diabetic group, and attenuated brain oxidative stress and AChE activity. Modafinil caused significant dyslipidaemia, increased body weight, whereas modestly altered abdominal circumference (AC) and thoracic circumference (TC) in rats. Significant hyperglycaemia, derangement of serum lipid-profile, brain lipid peroxidafion, cholinergic hypofunction, and decrease in body weight and AC-TC was noted in diabetic rats. Modafinil (100 mg/kg) significantly potentiated the hyperglycaemia and dyslipidaemia, however, attenuated oxidative stress and AChE activity in diabetic rats. Modafinil increased short-term (working) memory but not long-term spatial memory in normal and diabetic rats. CPP infusion attenuated these effects of modafinil.
   Conclusion: Subacute dosing of modafinil differentially modulates long-term and short-term memory subtypes, and also predisposes towards metabolic derangements.
C1 [Kumar, Manish; Maqbool, Shahnawaz] Swift Sch Pharm, Dept Pharmacol, Ghaggar Sarai Rajpura 140401, Punjab, India.
RP Kumar, M (corresponding author), Swift Sch Pharm, Dept Pharmacol, Ghaggar Sarai Rajpura 140401, Punjab, India.
EM mkpharmacology@gmail.com
RI KUMAR, MANISH/F-3188-2018
OI KUMAR, MANISH/0000-0001-6697-544X
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NR 39
TC 4
Z9 4
U1 0
U2 2
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0161-813X
EI 1872-9711
J9 NEUROTOXICOLOGY
JI Neurotoxicology
PD MAY
PY 2020
VL 78
BP 106
EP 115
DI 10.1016/j.neuro.2020.02.014
PG 10
WC Neurosciences; Pharmacology & Pharmacy; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Toxicology
GA LK8FE
UT WOS:000531094900013
PM 32126242
DA 2025-06-11
ER

EF﻿FN Clarivate Analytics Web of Science
VR 1.0
PT J
AU Tain, YL
   Wu, KLH
   Lee, WC
   Leu, S
   Chan, JYH
AF Tain, You-Lin
   Wu, Kay L. H.
   Lee, Wei-Chia
   Leu, Steve
   Chan, Julie Y. H.
TI Prenatal Metformin Therapy Attenuates Hypertension of Developmental
   Origin in Male Adult Offspring Exposed to Maternal High-Fructose and
   Post-Weaning High-Fat Diets
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE developmental origins of health and disease (DOHaD); high-fat; fructose;
   hypertension; metformin; nitric oxide; nutrient sensing signal;
   oxidative stress; renin angiotensin system
ID INDUCED PROGRAMMED HYPERTENSION; ACTIVATED PROTEIN-KINASE; SERUM
   URIC-ACID; OXIDATIVE STRESS; NITRIC-OXIDE; GENDER-DIFFERENCES; METABOLIC
   SYNDROME; IN-UTERO; KIDNEY; PREVENTS
AB Widespread consumption of a Western diet, comprised of highly refined carbohydrates and fat, may play a role in the epidemic of hypertension. Hypertension can take origin from early life. Metformin is the preferred treatment for type 2 diabetes. We examined whether prenatal metformin therapy can prevent maternal high-fructose plus post-weaning high-fat diets-induced hypertension of developmental origins via regulation of nutrient sensing signals, uric acid, oxidative stress, and the nitric oxide (NO) pathway. Gestating Sprague-Dawley rats received regular chow (ND) or chow supplemented with 60% fructose diet (HFR) throughout pregnancy and lactation. Male offspring were onto either the ND or high-fat diet (HFA) from weaning to 12 weeks of age. A total of 40 male offspring were assigned to five groups (n = 8/group): ND/ND, HFR/ND, ND/HFA, HFR/HFA, and HFR/HFA+ metformin. Metformin (500 mg/kg/day) was administered via gastric gavage for three weeks during the pregnancy period. Combined maternal HFR plus post-weaning HFA induced hypertension in male adult offspring, which prenatal metformin therapy prevented. The protective effects of prenatal metformin therapy on HFR/HFA-induced hypertension, including downregulation of the renin-angiotensin system, decrease in uric acid level, and reduction of oxidative stress. Our results highlighted that the programming effects of metformin administered prenatally might be different from those reported in adults, and that deserves further elucidation.
C1 [Tain, You-Lin] Kaohsiung Chang Gung Mem Hosp, Dept Pediat, Kaohsiung 833, Taiwan.
   [Tain, You-Lin; Wu, Kay L. H.; Lee, Wei-Chia; Leu, Steve; Chan, Julie Y. H.] Chang Gung Univ Coll Med, Kaohsiung 833, Taiwan.
   [Wu, Kay L. H.; Leu, Steve; Chan, Julie Y. H.] Kaohsiung Chang Gung Mem Hosp, Inst Translat Res Biomed, Kaohsiung 833, Taiwan.
   [Lee, Wei-Chia] Kaohsiung Chang Gung Mem Hosp, Dept Urol, Kaohsiung 833, Taiwan.
C3 Chang Gung Memorial Hospital; Chang Gung University; Chang Gung Memorial
   Hospital; Chang Gung Memorial Hospital
RP Chan, JYH (corresponding author), Chang Gung Univ Coll Med, Kaohsiung 833, Taiwan.; Chan, JYH (corresponding author), Kaohsiung Chang Gung Mem Hosp, Inst Translat Res Biomed, Kaohsiung 833, Taiwan.
EM tainyl@hotmail.com; wlh0701@yahoo.com.tw; dinor666@ms32.hinet.net;
   leu@mail.cgu.edu.tw; jchan@adm.cgmh.org.tw
RI Wu, Kay/ACD-1767-2022; Tain, You-Lin/H-2827-2019; Chan,
   Julie/X-5253-2019; Leu, Steve/D-6807-2011
OI Lee, Wei-Chia/0000-0003-0701-2285; Wu, Kay L.H./0000-0002-7297-6788;
   Tain, You-Lin/0000-0002-7059-6407
FU Chang Gung Memorial Hospital, Kaohsiung, Taiwan [CMRPG8F0022,
   CMRPG8G0191]
FX This work was supported by grants (CMRPG8F0022 and CMRPG8G0191) from
   Chang Gung Memorial Hospital, Kaohsiung, Taiwan.
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NR 37
TC 20
Z9 21
U1 0
U2 3
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD APR
PY 2018
VL 19
IS 4
AR 1066
DI 10.3390/ijms19041066
PG 13
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA GJ0XU
UT WOS:000434978700145
PM 29614026
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Narumi, M
   Takahashi, K
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   Yamanouchi, K
   Ohta, T
   Takahashi, T
   Kurachi, H
   Nagase, S
AF Narumi, Megumi
   Takahashi, Kazuhiro
   Yamatani, Hizuru
   Seino, Manabu
   Yamanouchi, Keiko
   Ohta, Tsuyoshi
   Takahashi, Toshifumi
   Kurachi, Hirohisa
   Nagase, Satoru
TI Oxidative Stress in the Visceral Fat Is Elevated in Postmenopausal Women
   with Gynecologic Cancer
SO JOURNAL OF WOMENS HEALTH
LA English
DT Article
DE estrogen; menopause; oxidative stress; adipocyte
ID ADIPOSE-TISSUE; METABOLIC SYNDROME; LIPOPROTEIN-LIPASE; CELL-SURVIVAL;
   RISK-FACTOR; ESTROGEN; OBESITY; 17-BETA-ESTRADIOL; EXPRESSION; RECEPTOR
AB Objectives: This study aimed to evaluate differences in oxidative stress of visceral fat between premenopausal and postmenopausal women and clarify the antioxidant effect of estrogen on adipocytes. Materials and Methods: Abdominal subcutaneous and omental visceral adipose tissues were obtained from 38 patients who underwent gynecological surgery. We measured the sizes of the adipocytes and evaluated the lipid peroxidation levels in the adipose tissues. We investigated whether estrogen inhibited the intracellular reactive oxygen species (ROS) production that was induced by hydrogen peroxide (H2O2) in 3T3-L1 adipocytes. Results: The visceral adipocytes were 1162.4m(2) and 1881.9m(2) in premenopausal and postmenopausal women, respectively; hence they were significantly larger in the latter (p<0.05). The lipid peroxidation levels were 46.7nmoL/mg protein in premenopausal women and 99.6nmoL/mg protein in postmenopausal women; hence the lipid peroxidation levels were significantly higher in the latter (p<0.05). Estradiol (E2) significantly reduced the intracellular ROS levels that were induced by H2O2 in 3T3-L1 adipocytes (p<0.01). We determined that E2 significantly increased the expression of nuclear factor erythroid 2-related factor 2 (NRF2)-dependent antioxidant genes, heme oxygenase-1 (HO-1), NAD(P)H:quinone oxidoreductase 1 (NQO1), and the glutamate-cysteine ligase (GCL) modifier subunit genes, in 3T3-L1 adipocytes (p<0.01). Conclusion: Oxidative stress in the visceral fat is higher in postmenopausal women. The expression of the antioxidant genes HO-1, NQO1, and GCL was upregulated by estrogen in 3T3-L1 adipocytes. Hence, estrogen may act as an antioxidant in the adipose tissues of premenopausal women.
C1 [Narumi, Megumi; Takahashi, Kazuhiro; Yamatani, Hizuru; Seino, Manabu; Yamanouchi, Keiko; Ohta, Tsuyoshi; Takahashi, Toshifumi; Nagase, Satoru] Yamagata Univ, Fac Med, Dept Obstet & Gynecol, 2-2-2 Iidanishi, Yamagata 9909585, Japan.
   [Kurachi, Hirohisa] Osaka Med Ctr, Izumi Ku, Osaka, Japan.
   [Kurachi, Hirohisa] Res Inst Maternal & Child Hlth, Izumi Ku, Osaka, Japan.
C3 Yamagata University; Osaka Medical Center for Cancer & Cardiovascular
   Diseases
RP Takahashi, K (corresponding author), Yamagata Univ, Fac Med, Dept Obstet & Gynecol, 2-2-2 Iidanishi, Yamagata 9909585, Japan.
EM ktaka@med.id.yamagata-u.ac.jp
RI SEINO, MANABU/MXK-3050-2025; Takahashi, Toshifumi/AAU-1848-2020
OI Nagase, Satoru/0000-0001-5212-1128
FU Ministry of Education, Culture, Sports, Science and Technology of Japan
   [23592433]; Grants-in-Aid for Scientific Research [15K10700, 23592433]
   Funding Source: KAKEN
FX This work was supported, in part, by Grants-in-Aid for Scientific
   Research No. 23592433 (K.T.) from the Ministry of Education, Culture,
   Sports, Science and Technology of Japan.
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NR 43
TC 6
Z9 6
U1 0
U2 7
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-9996
EI 1931-843X
J9 J WOMENS HEALTH
JI J. Womens Health
PD JAN
PY 2018
VL 27
IS 1
BP 99
EP 106
DI 10.1089/jwh.2016.6301
PG 8
WC Public, Environmental & Occupational Health; Medicine, General &
   Internal; Obstetrics & Gynecology; Women's Studies
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; General & Internal
   Medicine; Obstetrics & Gynecology; Women's Studies
GA FS8GE
UT WOS:000422647700013
PM 28816586
DA 2025-06-11
ER

PT J
AU Dallman, MF
   Akana, SF
   Pecoraro, NC
   Warne, JP
   la Fleur, SE
   Foster, MT
AF Dallman, Mary F.
   Akana, Susan F.
   Pecoraro, Norman C.
   Warne, James P.
   la Fleur, Susanne E.
   Foster, Michelle T.
TI Glucocorticoids, the etiology of obesity and the metabolic syndrome
SO CURRENT ALZHEIMER RESEARCH
LA English
DT Article; Proceedings Paper
CT Workshop on Exploring the Links between Obesity and Alzheimers Disease
CY JUN 20-21, 2006
CL Bethesda, MD
DE corticotropin-releasing factor (CRF); type 2 diabetes; abdominal fat;
   sugar; fat
ID CORTICOTROPIN-RELEASING-FACTOR; STRESS-INDUCED CORTISOL; CIRCADIAN
   RHYTHMICITY; ADRENALECTOMIZED RATS; ADRENOCORTICAL AXIS;
   ALZHEIMERS-DISEASE; SUCROSE INGESTION; ENERGY STORES; CORTICOSTERONE;
   SLEEP
AB In mammals, glucocorticoid actions appear to have evolved to maintain and enhance energy stores to be used for life-saving gluconeogenesis. They act on the brain to stimulate search behaviors, palatable feeding and emotionally relevant memories, and they act on the body to mobilize stored peripheral energy and direct it to central depots that serve the substrate needs of the liver. Our work in rats shows that searching and intake of palatable foods (sucrose, saccharin and lard) are stimulated by corticosterone in a dose-related fashion. Adrenalectomized rats gain weight poorly, have low fat content, increased sympathetic neural and hypothalamo-pituitary-adrenal outflow, and altered behaviors. Replacement with corticosterone reverses these effects. Surprisingly, when such rats are provided with 30% sucrose to drink, in addition to saline, all of the usual effects of adrenalectomy are corrected without corticosterone. We hypothesize that there is a metabolic feedback system that decreases stress-responsiveness. Although we have not yet identified the signal associated with sucrose drinking, the weight of mesenteric fat correlates inversely with hypothalamic corticotropin-releasing factor (CRF). When rats eat lard and sucrose ad libitum, fat stores increase and CRF, ACTH and corticosterone responses are reduced. During stress, chow intake decreases but intake of lard and sucrose does not. Our current working model suggests that palatability signals and neural signals from fat stores act on brain to reduce activity in the central stress response system. Correlative results from a clinical study support the powerful role of small changes in glucocorticoids in type 2 diabetes.
C1 Univ Calif San Francisco, Sch Med, Dept Physiol, San Francisco, CA 94143 USA.
C3 University of California System; University of California San Francisco
RP Dallman, MF (corresponding author), Univ Calif San Francisco, Sch Med, Dept Physiol, 513 Parnassus Ave, San Francisco, CA 94143 USA.
EM mary.dallman@ucsf.edu
RI Dallman, Mary/B-4816-2010
FU NIDA NIH HHS [DA16944] Funding Source: Medline; NIDDK NIH HHS [DK28172]
   Funding Source: Medline
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NR 62
TC 46
Z9 57
U1 0
U2 10
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1567-2050
EI 1875-5828
J9 CURR ALZHEIMER RES
JI Curr. Alzheimer Res.
PD APR
PY 2007
VL 4
IS 2
BP 199
EP 204
DI 10.2174/156720507780362236
PG 6
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Neurosciences & Neurology
GA 156BH
UT WOS:000245622400019
PM 17430247
DA 2025-06-11
ER

PT J
AU Mazur, A
   Maier, JAM
   Rock, E
   Gueux, E
   Nowacki, W
   Rayssiguier, Y
AF Mazur, Andrzej
   Maier, Jeanette A. M.
   Rock, Edmond
   Gueux, Elyett
   Nowacki, Wojciech
   Rayssiguier, Yves
TI Magnesium and the inflammatory response: Potential physiopathological
   implications
SO ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
LA English
DT Review
DE magnesium; inflammation; deficiency; cardiovascular diseases; cytokines;
   oxidative stress; endothelium; plasma lipids
ID TRIGLYCERIDE-RICH LIPOPROTEINS; CORONARY-ARTERY-DISEASE; BLOOD-CELL
   GLUTATHIONE; TRAUMATIC BRAIN-INJURY; VASCULAR SMOOTH-MUSCLE;
   NITRIC-OXIDE SYNTHASE; MESSENGER-RNA LEVELS; DEFICIENT RAT MODEL;
   C-REACTIVE PROTEIN; HIGH SUCROSE DIET
AB The purpose of this review is to summarize experimental findings showing that magnesium modulates cellular events involved in inflammation. Experimental magnesium deficiency in the rat induces after a few days a clinical inflammatory syndrome characterized by leukocyte and macrophage activation, release of inflammatory cytokines and acute phase proteins, excessive production of free radicals. Increase in extracellular magnesium concentration, decreases inflammatory response while reduction in the extracellular magnesium results in cell activation. Because magnesium acts as a natural calcium antagonist, the molecular basis for inflammatory response is probably the result of modulation of intracellular calcium concentration. The priming of phagocytic cells, the opening calcium channel and activation of N-methyl-D-aspartate (NMDA) receptors, the activation of nuclear factor-kappa B (NF kappa B) have been considered as potential mechanisms. Moreover, magnesium deficiency induces a systemic stress response by activation of neuro endocrinological pathways. As nervous and immune systems interact bidirectionally, the roles of neuromediators have also been considered. Magnesium deficiency contributes to an exaggerated response to immune stress and oxidative stress is the consequence of the inflammatory response. Inflammation contributes to the pro-atherogenic changes in lipoprotein metabolism, endothelial dysfunction, thrombosis, hypertension and explains the aggravating effect of magnesium deficiency on the development of metabolic syndrome. Further studies are still needed to assess more accurately the role of magnesium in immune response in humans, but these experimental findings in animal models suggest that inflammation is the missing link to explain the role of magnesium in many pathological conditions. (c) 2006 Elsevier Inc. All rights reserved.
C1 INRA, Ctr Rech Nutr Humaine Auvergne, UMR 1019, Unite Nutr Humaine,Equipe Stress Metab & Micronut, F-63122 St Genes Champanelle, France.
   Univ Milan, Dept Preclin Sci, LITA Vialba, I-20157 Milan, Italy.
   Agr Univ Warsaw, Fac Vet, Dept Vet Prevent & Immunol, PL-50375 Wroclaw, Poland.
C3 INRAE; University of Milan; Warsaw University of Life Sciences
RP Mazur, A (corresponding author), INRA, Ctr Rech Nutr Humaine Auvergne, UMR 1019, Unite Nutr Humaine,Equipe Stress Metab & Micronut, F-63122 St Genes Champanelle, France.
EM mazur@clermont.inra.fr
RI ; Mazur, Andre/AAG-9751-2020; Maier, Jeanette Anne Marie/H-4820-2012
OI Nowacki, Wojciech/0000-0002-8304-0686; Mazur, Andre/0000-0002-1067-5066;
   Maier, Jeanette Anne Marie/0000-0002-6326-9221
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NR 122
TC 364
Z9 392
U1 1
U2 55
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0003-9861
EI 1096-0384
J9 ARCH BIOCHEM BIOPHYS
JI Arch. Biochem. Biophys.
PD FEB 1
PY 2007
VL 458
IS 1
BP 48
EP 56
DI 10.1016/j.abb.2006.03.031
PG 9
WC Biochemistry & Molecular Biology; Biophysics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics
GA 137AI
UT WOS:000244264800007
PM 16712775
DA 2025-06-11
ER

PT J
AU Su, ZQ
   Guo, YR
   Huang, XF
   Feng, B
   Tang, LP
   Zheng, GJ
   Zhu, Y
AF Su, Zuqing
   Guo, Yanru
   Huang, Xiufang
   Feng, Bing
   Tang, Lipeng
   Zheng, Guangjuan
   Zhu, Ying
TI Phytochemicals: Targeting Mitophagy to Treat Metabolic Disorders
SO FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
LA English
DT Review
DE phytochemicals; metabolic disorders; mitophagy; mitochondrial
   dysfunction; oxidative stress; inflammatory response
ID SALVIANOLIC ACID B; LIPOPROTEIN-INDUCED INJURY; FATTY LIVER-DISEASE;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; BLOOD-PRESSURE; MITOCHONDRIAL
   DYNAMICS; NOTOGINSENOSIDE R1; CLINICAL-TRIAL; RESVERATROL
   SUPPLEMENTATION
AB Metabolic disorders include metabolic syndrome, obesity, type 2 diabetes mellitus, nonalcoholic fatty liver disease and cardiovascular diseases. Due to unhealthy lifestyles such as high-calorie diet, sedentary and physical inactivity, the prevalence of metabolic disorders poses a huge challenge to global human health, which is the leading cause of global human death. Mitochondrion is the major site of adenosine triphosphate synthesis, fatty acid beta-oxidation and ROS production. Accumulating evidence suggests that mitochondrial dysfunction-related oxidative stress and inflammation is involved in the development of metabolic disorders. Mitophagy, a catabolic process, selectively degrades damaged or superfluous mitochondria to reverse mitochondrial dysfunction and preserve mitochondrial function. It is considered to be one of the major mechanisms responsible for mitochondrial quality control. Growing evidence shows that mitophagy can prevent and treat metabolic disorders through suppressing mitochondrial dysfunction-induced oxidative stress and inflammation. In the past decade, in order to expand the range of pharmaceutical options, more and more phytochemicals have been proven to have therapeutic effects on metabolic disorders. Many of these phytochemicals have been proved to activate mitophagy to ameliorate metabolic disorders. Given the ongoing epidemic of metabolic disorders, it is of great significance to explore the contribution and underlying mechanisms of mitophagy in metabolic disorders, and to understand the effects and molecular mechanisms of phytochemicals on the treatment of metabolic disorders. Here, we investigate the mechanism of mitochondrial dysfunction in metabolic disorders and discuss the potential of targeting mitophagy with phytochemicals for the treatment of metabolic disorders, with a view to providing a direction for finding phytochemicals that target mitophagy to prevent or treat metabolic disorders.
C1 [Su, Zuqing; Guo, Yanru; Huang, Xiufang; Feng, Bing; Tang, Lipeng; Zheng, Guangjuan; Zhu, Ying] Guangzhou Univ Chinese Med, Guangdong Prov Hosp Chinese Med, Clin Coll 2, Guangzhou, Peoples R China.
   [Guo, Yanru] Guizhou Univ Tradit Chinese Med, Guiyang, Peoples R China.
   [Huang, Xiufang] Guangzhou Univ Chinese Med, Affiliated Hosp 1, Guangzhou, Peoples R China.
C3 Guangzhou University of Chinese Medicine; Guizhou University of
   Traditional Chinese Medicine; Guangzhou University of Chinese Medicine
RP Zheng, GJ; Zhu, Y (corresponding author), Guangzhou Univ Chinese Med, Guangdong Prov Hosp Chinese Med, Clin Coll 2, Guangzhou, Peoples R China.
EM zhengguangjuan@gzucm.edu.cn; zhuying3340@gzucm.edu.cn
RI Zou, Guodong/HJG-8434-2022; Tang, Lipeng/ABB-6481-2020; Zheng,
   Guangjuan/ABB-6496-2020
FU National Natural Science Foundation of China [81703770]; Chinese
   Medicine Scientific Research and Technology Research Projects of
   Guangdong Provincial Hospital of Chinese Medicine [YN2018QJ04,
   YN2019QJ10]; Guangdong Provincial Key Laboratory of Chinese Medicine for
   Prevention and Treatment of Refractory Chronic Diseases [2018B030322012]
FX This work was supported by grants from the National Natural Science
   Foundation of China (grant number 81703770) , the Chinese Medicine
   Scientific Research and Technology Research Projects of Guangdong
   Provincial Hospital of Chinese Medicine (grant numbers YN2018QJ04 and
   YN2019QJ10) and Guangdong Provincial Key Laboratory of Chinese Medicine
   for Prevention and Treatment of Refractory Chronic Diseases (grant
   number 2018B030322012) .
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NR 188
TC 22
Z9 23
U1 3
U2 30
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-634X
J9 FRONT CELL DEV BIOL
JI Front. Cell. Dev. Biol.
PD APR 1
PY 2021
VL 9
AR 686820
DI 10.3389/fcell.2021.686820
PG 19
WC Cell Biology; Developmental Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Developmental Biology
GA UA2HG
UT WOS:000684984700009
PM 34414181
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Abbas, AM
   Sakr, HF
AF Abbas, Amr M.
   Sakr, Hussein F.
TI Simvastatin and vitamin E effects on cardiac and hepatic oxidative
   stress in rats fed on high fat diet
SO JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
LA English
DT Article
DE Simvastatin; Vitamin E; Hypercholesterolemia; Oxidative stress; Liver;
   Heart
ID HIGH CHOLESTEROL DIET; CORONARY-HEART-DISEASE; LEAF EXTRACT;
   HYPERCHOLESTEROLEMIA; INJURY; DYSFUNCTION; MORTALITY; TISSUES; MODELS;
   RISK
AB High fat diet (HFD) is a common cause of metabolic syndrome and type 2 diabetes mellitus. Published data showed that HFD and subsequent dyslipidemia are major triggers for oxidative stress. Forty-eight male Sprague-Dawley rats, weighing 170-200 g, were divided into six groups: control, control with vitamin E (100 mg/kg/day, i.p.), control with simvastatin (SIM) (10 mg/kg of body weight/day), HFD, HFD with vitamin E, and HFD with SIM. Standard and high cholesterol diets were given for 15 weeks and SIM and vitamin E were added in the last 4 weeks. In all rats, serum vitamin E, total cholesterol (TC), triglycerides (TG), low (LDL) and high (HDL) density lipoproteins, alanine (ALT) and aspartate (AST) transaminases, alkaline phosphatase (ALP), and gamma glutamyl transpeptidase (GGT) as well as cardiac and hepatic thiobarbituric acid-reactive substances (TBARS) and antioxidants (reduced glutathione (GSH), superoxide dismutase (SOD), and catalase (CAT)) were measured. Also, electrocardiogram (ECG) was recorded. HFD significantly increased QTc interval, heart rate (HR), serum TC, TG, LDL, ALT, AST, ALP, GGT, liver TG, and cardiac and hepatic TBARS but decreased antioxidants and HDL, while SIM decreased HR, liver TG, serum TC, TG, and LDL and increased HDL in HFD rats. Vitamin E had no effect. Moreover, SIM and vitamin E decreased QTc interval, serum ALT, AST, ALP, GGT, and cardiac and hepatic TBARS and increased antioxidants in HFD rats. Histopathological observations confirm the biochemical parameters. SIM and vitamin E slow progression of hypercholesterolemia-induced oxidative stress in liver and heart and improve their functions.
C1 [Abbas, Amr M.; Sakr, Hussein F.] Mansoura Univ, Fac Med, Dept Med Physiol, Mansoura, Egypt.
   [Sakr, Hussein F.] King Khalid Univ, Coll Med, Dept Med Physiol, Abha, Saudi Arabia.
C3 Egyptian Knowledge Bank (EKB); Mansoura University; King Khalid
   University
RP Sakr, HF (corresponding author), Mansoura Univ, Fac Med, Dept Med Physiol, POB 35516, Mansoura, Egypt.
EM sakr_doctor@yahoo.com
RI Sakr, Hussein/O-4888-2018; Abbas, Amr/G-6979-2017
OI Abbas, Amr/0000-0001-6525-7673
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NR 47
TC 44
Z9 47
U1 0
U2 26
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1138-7548
EI 1877-8755
J9 J PHYSIOL BIOCHEM
JI J. Physiol. Biochem.
PD DEC
PY 2013
VL 69
IS 4
BP 737
EP 750
DI 10.1007/s13105-013-0250-y
PG 14
WC Biochemistry & Molecular Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Physiology
GA 253EE
UT WOS:000327064200007
PM 23580160
DA 2025-06-11
ER

PT J
AU Kelishadi, R
   Mirghaffari, N
   Poursafa, P
   Gidding, SS
AF Kelishadi, Roya
   Mirghaffari, Nourollah
   Poursafa, Parinaz
   Gidding, Samuel S.
TI Lifestyle and environmental factors associated with inflammation,
   oxidative stress and insulin resistance in children
SO ATHEROSCLEROSIS
LA English
DT Article
DE Air pollution; Lifestyle; Children; Inflammation; Oxidation
ID C-REACTIVE PROTEIN; PARTICULATE AIR-POLLUTION; ATHEROSCLEROTIC
   RISK-FACTORS; NUTRITION EXAMINATION SURVEY; CORONARY-HEART-DISEASE;
   BODY-MASS INDEX; PHYSICAL-ACTIVITY; METABOLIC SYNDROME; SYSTEMIC
   INFLAMMATION; DIETARY PATTERNS
AB Background: Reaching a better understanding of the modifiable factors associated with inflammatory and oxidative biomarkers in children would be relevant to the design of further investigation and prevention strategies. Objective: To determine the association of air pollution as well as dietary and physical activity habits with markers of inflammation, oxidative stress and insulin resistance for the first time in a population-based sample of children.
   Methods: We conducted a population-based study of 374 children, aged 10-18 years, and assessed the exposure of participants to air pollutants as well as their dietary and physical activity habits. In addition to anthropotnetric and blood pressure measurements, we determined the fasting serum levels of lipid profile, insulin and markers of inflammation and oxidation.
   Results: We found independent associations between improper air quality and plasma markers of inflammation, oxidative stress and insulin resistance. The Pollutant Standard Index (PSI) and the level of fine particulate matter were significantly associated to all biomarkers studied. The associations between different markers of air pollutants and markers of inflammation, oxidative stress and insulin resistance remained significant after adjustment for age, gender, body mass index, waist circumference, healthy eating index and physical activity level. The association of healthy eating score with CRP and insulin resistance was mediated through anthropometric indices, and physical activity had independent association with insulin resistance.
   Conclusion: The independent influence of inflammatory/oxidative mechanisms of air pollution effects on surrogate markers of atherosclerosis from early life should be highlighted. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
C1 [Kelishadi, Roya] Isfahan Univ Med Sci, Pediat Prevent Cardiol Dept, Isfahan Cardiovasc Res Ctr, POB 81465-1148, Esfahan, Iran.
   [Mirghaffari, Nourollah; Poursafa, Parinaz] Isfahan Univ Technol, Esfahan, Iran.
   [Gidding, Samuel S.] AJ DuPont Childrens Hosp, Nemours Cardiac Ctr, Wilmington, DE USA.
   [Gidding, Samuel S.] Thomas Jefferson Univ, Wilmington, DE USA.
C3 Isfahan University of Medical Sciences; Isfahan University of
   Technology; Thomas Jefferson University; Jefferson Medical College
RP Kelishadi, R (corresponding author), Isfahan Univ Med Sci, Pediat Prevent Cardiol Dept, Isfahan Cardiovasc Res Ctr, POB 81465-1148, Esfahan, Iran.
EM kroya@aap.net
RI Mirghaffari, Nourollah/AAC-6955-2019; Poursafa, Parinaz/U-2924-2017;
   Kelishadi, Roya/E-6154-2012
OI Poursafa, Parinaz/0000-0002-8067-4122; Kelishadi,
   Roya/0000-0001-7455-1495; Mirghaffari, Nourollah/0000-0003-3779-0950;
   Gidding, Samuel/0000-0002-8557-7225
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   *WHO, 2004, EFF AIR POLL CHILD H
NR 58
TC 191
Z9 205
U1 0
U2 35
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0021-9150
EI 1879-1484
J9 ATHEROSCLEROSIS
JI Atherosclerosis
PD MAR
PY 2009
VL 203
IS 1
BP 311
EP 319
DI 10.1016/j.atherosclerosis.2008.06.022
PG 9
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 423QL
UT WOS:000264510700047
PM 18692848
DA 2025-06-11
ER

PT J
AU Jinam, TA
   Phipps, ME
   Indran, M
   Kuppusamy, UR
   Mahmood, AA
   Hong, LC
   Edo, J
AF Jinam, Timothy Adrian
   Phipps, Maude Elvira
   Indran, Mathavan
   Kuppusamy, Umah Rani
   Mahmood, Abdulla Ameen
   Hong, Lih-Chun
   Edo, Juli
TI An update of the general health status in the indigenous populations of
   Malaysia
SO ETHNICITY & HEALTH
LA English
DT Article
DE indigenous communities; health; oxidative stress
ID OXIDATIVE STRESS; METABOLIC SYNDROME; PREVALENCE; PLASMA; COMMITTEE;
   LIPIDS
AB Objectives. Health scenarios are constantly evolving, particularly in developing countries but little is known regarding the health status of indigenous groups in Malaysia. This study aims to elucidate the current health status in four indigenous populations in the country, who by and large been left out of mainstream healthcare developments.
   Methods. Participants were recruited from the Temuan, Jehai, Kensiu and Bidayuh indigenous groups throughout Peninsula Malaysia and Sarawak. Health parameters including body mass index (BMI), blood pressure, casual blood glucose and, total cholesterol levels were measured using established methods. Malondialdehyde (MDA) and ferric-reducing antioxidant power (FRAP) levels were measured to assess oxidative stress status. Blood films were screened for evidence of microbial or parasitic infections and leukocyte differential counting was performed.
   Results. The Temuan and Bidayuh who are more urbanized, had significantly higher mean body weight, BMI, total cholesterol (p0.05) and higher prevalence of obesity and hypercholesterolemia. Low cholesterol levels, elevated eosinophil counts and increased total IgE, indicative of immune responses to infection or allergy, were recorded in the rural Kensiu and Jehai. The Kensiu had higher levels of FRAP and lower levels of MDA, whereas the reverse was found in the Temuan. This suggests reduced oxidative stress in the Kensiu compared to the Temuan. Expected correlations between FRAP and MDA levels with age, were evident in Jehai.
   Conclusions. Our findings reflect a shifting health burden and an epidemiological transition, particularly in the Temuan and Bidayuh. These changes could be attributed to dietary habits, lifestyles and socio-economic factors brought about by urbanization.
C1 [Jinam, Timothy Adrian; Phipps, Maude Elvira; Indran, Mathavan; Kuppusamy, Umah Rani; Mahmood, Abdulla Ameen; Hong, Lih-Chun] Univ Malaya, Fac Med, Dept Mol Med, Kuala Lumpur, Malaysia.
   [Edo, Juli] Univ Malaya, Inst Res Management & Consultancy, Ctr Malaysian Pribumi Studies, Kuala Lumpur, Malaysia.
C3 Universiti Malaya; Universiti Malaya
RP Phipps, ME (corresponding author), Univ Malaya, Fac Med, Dept Mol Med, Kuala Lumpur, Malaysia.
EM maudephipps@yahoo.co.uk
RI Jinam, Timothy/KIE-6591-2024; KUPPUSAMY, UMAH RANI/B-9981-2010; EDO,
   JULI/B-8721-2010; Phipps, Maude/F-7590-2012
OI Phipps, Maude/0000-0001-8314-068X; Jinam, Timothy
   Adrian/0000-0003-4757-096X
CR Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
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NR 33
TC 9
Z9 9
U1 0
U2 5
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 1355-7858
EI 1465-3419
J9 ETHNIC HEALTH
JI Ethn. Health
PY 2008
VL 13
IS 3
BP 277
EP 287
DI 10.1080/13557850801930478
PG 11
WC Ethnic Studies; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Ethnic Studies; Public, Environmental & Occupational Health
GA 317QU
UT WOS:000257035500006
PM 18568977
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Cho, IJ
   Oh, DH
   Yoo, J
   Hwang, YC
   Ahn, KJ
   Chung, HY
   Jeong, SW
   Moon, JY
   Lee, SH
   Lim, SJ
   Jeong, IK
AF Cho, In-Jin
   Oh, Da-Hee
   Yoo, Jin
   Hwang, You-Cheol
   Ahn, Kyu Jeung
   Chung, Ho-Yeon
   Jeong, Soung Won
   Moon, Ju-Young
   Lee, Sang-Ho
   Lim, Sung-Jig
   Jeong, In-Kyung
TI Allopurinol ameliorates high fructose diet induced hepatic steatosis in
   diabetic rats through modulation of lipid metabolism, inflammation, and
   ER stress pathway
SO SCIENTIFIC REPORTS
LA English
DT Article
ID NONALCOHOLIC FATTY LIVER; ENDOPLASMIC-RETICULUM STRESS;
   GLUCOSE-TOLERANCE TEST; URIC-ACID; INSULIN-RESISTANCE; DISEASE;
   STEATOHEPATITIS; ACTIVATION; PLACEBO; COMPLICATIONS
AB Excess fructose consumption contributes to development obesity, metabolic syndrome, and nonalcoholic fatty liver disease (NAFLD). Uric acid (UA), a metabolite of fructose metabolism, may have a direct role in development of NAFLD, with unclear mechanism. This study aimed to evaluate role of fructose and UA in NAFLD and explore mechanisms of allopurinol (Allo, a UA lowering medication) on NAFLD in Otsuka Long-Evans Tokushima Fatty (OLETF) rats fed a high fructose diet (HFrD), with Long-Evans Tokushima Otsuka (LETO) rats used as a control. There were six groups: LETO, LETO-Allo, OLETF, OLETF-Allo, OLETF-HFrD, and OLETF-HFrD-Allo. HFrD significantly increased body weight, epididymal fat weight, and serum concentrations of UA, cholesterol, triglyceride, HbA1c, hepatic enzymes, HOMA-IR, fasting insulin, and two hour-glucose after intraperitoneal glucose tolerance tests, as well as NAFLD activity score of liver, compared to the OLETF group. Allopurinol treatment significantly reduced hepatic steatosis, epididymal fat, serum UA, HOMA-IR, hepatic enzyme levels, and cholesterol in the OLETF-HFrD-Allo group. Additionally, allopurinol significantly downregulated expression of lipogenic genes, upregulated lipid oxidation genes, downregulated hepatic pro-inflammatory cytokine genes, and decreased ER-stress induced protein expression, in comparison with the OLETF-HFrD group. In conclusion, allopurinol ameliorates HFrD-induced hepatic steatosis through modulation of hepatic lipid metabolism, inflammation, and ER stress pathway. UA may have a direct role in development of fructose-induced hepatic steatosis, and allopurinol could be a candidate for prevention or treatment of NAFLD.
C1 [Cho, In-Jin; Oh, Da-Hee; Yoo, Jin; Hwang, You-Cheol; Ahn, Kyu Jeung; Chung, Ho-Yeon; Jeong, In-Kyung] Kyung Hee Univ, Kyung Hee Univ Hosp Gangdong, Dept Endocrinol & Metab, Sch Med, 892 Dongnam Ro, Seoul 05278, South Korea.
   [Hwang, You-Cheol; Ahn, Kyu Jeung; Chung, Ho-Yeon; Jeong, In-Kyung] Kyung Hee Univ, Dept Internal Med, Div Endocrinol & Metab, Sch Med, Seoul, South Korea.
   [Jeong, Soung Won] Soonchunhyang Univ, Dept Internal Med, Div Gastroenterol & Hepatol, Coll Med, Seoul, South Korea.
   [Moon, Ju-Young; Lee, Sang-Ho] Kyung Hee Univ, Dept Internal Med, Div Nephrol, Sch Med, Seoul, South Korea.
   [Lim, Sung-Jig] Kyung Hee Univ, Dept Pathol, Sch Med, Seoul, South Korea.
C3 Kyung Hee University; Kyung Hee University Hospital; Kyung Hee
   University; Soonchunhyang University; Kyung Hee University; Kyung Hee
   University
RP Jeong, IK (corresponding author), Kyung Hee Univ, Kyung Hee Univ Hosp Gangdong, Dept Endocrinol & Metab, Sch Med, 892 Dongnam Ro, Seoul 05278, South Korea.; Jeong, IK (corresponding author), Kyung Hee Univ, Dept Internal Med, Div Endocrinol & Metab, Sch Med, Seoul, South Korea.
EM jik1016@naver.com
RI Hwang, You-Cheol/AAA-4616-2022; Jeong, In-Kyung/AAI-6488-2020; Moon,
   Ju-Young/T-6959-2019; Yoo, Jin/GXM-5206-2022
FU National Research Foundation of Korea (NRF) [NRF-20110013729]; Korean
   government (MEST); Korean Diabetes Association [2016F-1]; Korea Health
   Technology R&D Project through the Korea Health Industry Development
   Institute - Ministry of Health & Welfare, Republic of Korea [HI17C2060]
FX This work was supported by the National Research Foundation of Korea
   (NRF) [Grant Number NRF-20110013729] funded by the Korean government
   (MEST); the Korean Diabetes Association [Grant Number I.J.C., 2016F-1],
   and the Korea Health Technology R&D Project through the Korea Health
   Industry Development Institute, funded by the Ministry of Health &
   Welfare, Republic of Korea [Grant Number HI17C2060].
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NR 61
TC 24
Z9 24
U1 0
U2 11
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD MAY 10
PY 2021
VL 11
IS 1
AR 9894
DI 10.1038/s41598-021-88872-7
PG 13
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA SO1MW
UT WOS:000658744700023
PM 33972568
OA Green Published
DA 2025-06-11
ER

PT J
AU Shahraki, ZS
   Karbalaei, N
   Nemati, M
AF Shahraki, Zahra Shabgard
   Karbalaei, Narges
   Nemati, Marzieh
TI Improving effect of combined inorganic nitrate and nitric oxide synthase
   inhibitor on pancreatic oxidative stress and impaired insulin secretion
   in streptozotocin induced-diabetic rats
SO JOURNAL OF DIABETES AND METABOLIC DISORDERS
LA English
DT Article
DE Nitrate; Nitric oxide synthase inhibitor; Oxidative stress; Insulin
   secretion
ID METABOLIC SYNDROME; L-NAME; ISLETS; NO; ANTIOXIDANT; EXPRESSION; MODEL;
   INOS
AB Purpose The aim of this study was to evaluate the effect of dietary nitrate on secretory function of pancreatic islet and oxidative stress status in streptozotocin (STZ) induced type 1 diabetes in absence or presence of nitric oxide synthase inhibitor (L-NAME). Methods Fifty adult male sprague-dawly rats were divided into 5 groups: controls (C), diabetes (D), diabetes+nitrate (DN), diabetes +L-NAME (D + Ln), and diabetes+nitrate+L-NAME (DN + Ln) for 45 days. The concentrations of sodium nitrate and L-NAME were respectively 80 mg/L in drinking water and 5 mg/kg intraperitoneally. Body weight gain, plasma levels of glucose and insulin, islet insulin secretion and content, lipid peroxidation and antioxidant status in the pancreas of rats were determined. Results Compared to control group, the body weight gain and plasma insulin level were significantly decreased and plasma glucose and pancreatic NO and MDA concentrations and antioxidant enzymes activities were significantly increased in the STZ diabetic rats. In the diabetic rats, nitrate alone significantly reduced plasma glucose and increased pancreatic SOD and GPx activity. Reduced plasma glucose, pancreatic MDA and NO concentrations and increased plasma insulin level and pancreatic islet insulin secretion were observed in D + Ln and DN + Ln groups. Antioxidant enzymes activities were increased in diabetic rats which received combination of nitrate and L-NAME. Conclusions Our results showed that nitrate without effect on pancreatic islet insulin content and secretion decreased the blood glucose and slightly moderate oxidative stress and its effects in the presence of L-NAME on glucose hemostasis and pancreatic insulin secretion higher than those of nitrate alone.
C1 [Shahraki, Zahra Shabgard; Karbalaei, Narges; Nemati, Marzieh] Shiraz Univ Med Sci, Fac Med, Dept Physiol, Shiraz, Iran.
   [Karbalaei, Narges] Shiraz Univ Med Sci, Histomorphometry & Stereol Res Ctr, Shiraz, Iran.
C3 Shiraz University of Medical Science; Shiraz University of Medical
   Science
RP Karbalaei, N (corresponding author), Shiraz Univ Med Sci, Fac Med, Dept Physiol, Shiraz, Iran.; Karbalaei, N (corresponding author), Shiraz Univ Med Sci, Histomorphometry & Stereol Res Ctr, Shiraz, Iran.
EM Karbalai@sums.ac.ir
RI Karbalaei, Narges/T-7353-2017
OI Karbalaei, Narges/0000-0003-4619-2872
FU Shiraz University of Medical Sciences, Shiraz, Iran [12977]
FX The present work was financially supported by Shiraz University of
   Medical Sciences, Shiraz, Iran (grant no. 12977); it is a part of Ms.
   Thesis by Zahra Shabgard Shahraki. The funders had no role in study
   design, data collection and analysis and preparation of the manuscript.
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NR 48
TC 3
Z9 3
U1 0
U2 4
PU SPRINGER INT PUBL AG
PI CHAM
PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND
EI 2251-6581
J9 J DIABETES METAB DIS
JI J. Diabetes Metab. Disord.
PD JUN
PY 2020
VL 19
IS 1
BP 353
EP 362
DI 10.1007/s40200-020-00516-1
EA MAR 2020
PG 10
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA NR3GL
UT WOS:000521538600001
PM 32550186
OA Green Published
DA 2025-06-11
ER

PT J
AU Mazzoli, A
   Crescenzo, R
   Cigliano, L
   Spagnuolo, MS
   Cancelliere, R
   Gatto, C
   Iossa, S
AF Mazzoli, Arianna
   Crescenzo, Raffaella
   Cigliano, Luisa
   Spagnuolo, Maria Stefania
   Cancelliere, Rosa
   Gatto, Cristina
   Iossa, Susanna
TI Early Hepatic Oxidative Stress and Mitochondrial Changes Following
   Western Diet in Middle Aged Rats
SO NUTRIENTS
LA English
DT Article
DE middle age; liver mitochondria; oxidative stress; high fat-high fructose
   diet; inflammation; hepatic cholesterol
ID HIGH-FAT DIET; INSULIN-RESISTANCE; METABOLIC SYNDROME; HIGH-FRUCTOSE;
   SKELETAL-MUSCLE; ADIPOSE-TISSUE; LIVER; LIPOCALIN-2; STEATOSIS;
   INFLAMMATION
AB To assess the effect of 4 weeks of high fat-high fructose feeding on whole body composition, energy balance, specific markers of oxidative stress and inflammation, and insulin sensitivity in the liver of middle-aged rats, rats (1 year) were fed a diet rich in saturated fatty acids and fructose (HFF rats), mimicking the "Western diet", and compared with rats of the same age that were fed a low fat diet (LF rats). HFF rats exhibited a significant increase in the gain of body weight, energy, and lipids compared to LF rats. HFF rats also showed hepatic insulin resistance, together with an increase in plasma triglycerides, cholesterol, and tumor necrosis factor alpha. Hepatic lipids, triglycerides and cholesterol were higher in HFF rats, while a significant decrease in Stearoyl-CoA desaturase activity was found in this tissue. A marked increase in the protein amount of complex I, concomitant to a decrease in its contribution to mitochondrial respiration, was found in HFF rats. Lipid peroxidation and Nitro-Tyrosine content, taken as markers of oxidative stress, as well as NADPH oxidase activity, were significantly higher in HFF rats, while the antioxidant enzyme catalase decreased in these rats. Myeloperoxidase activity and lipocalin content increased, while peroxisome proliferator activated receptor gamma decreased in HFF rats. The present results provide evidence that middle-aged rats show susceptibility to a short-term "Western diet", exhibiting altered redox homeostasis, insulin resistance, and early mitochondrial alterations in the liver. Therefore, this type of dietary habits should be drastically limited to pursue a "healthy aging".
C1 [Mazzoli, Arianna; Crescenzo, Raffaella; Cigliano, Luisa; Cancelliere, Rosa; Gatto, Cristina; Iossa, Susanna] Univ Naples Federico II, Dept Biol, Via Cintia, I-80126 Naples, Italy.
   [Spagnuolo, Maria Stefania] Natl Res Council Naples CNR ISPAAM, Inst Anim Prod Syst Mediterranean Environm, Dept Bioagrofood Sci, I-80147 Naples, Italy.
C3 University of Naples Federico II; Consiglio Nazionale delle Ricerche
   (CNR); Istituto Per Il Sistema Produzione Animale In Ambiente
   Mediterraneo (ISPAAM-CNR)
RP Iossa, S (corresponding author), Univ Naples Federico II, Dept Biol, Via Cintia, I-80126 Naples, Italy.
EM arianna.mazzoli@unina.it; rcrescen@unina.it; luisa.cigliano@unina.it;
   mariastefania.spagnuolo@cnr.it; cancelliererosa@gmail.com;
   crigatto51@gmail.com; susiossa@unina.it
RI Spagnuolo, Maria/B-7661-2015; Cigliano, Luisa/AEL-3260-2022; IOSSA,
   Susanna/O-1625-2016
OI CIGLIANO, Luisa/0000-0002-5491-9659; GATTO,
   CRISTINA/0000-0003-1658-8470; mazzoli, arianna/0000-0003-4096-443X;
   IOSSA, Susanna/0000-0001-6103-718X; CRESCENZO,
   Raffaella/0000-0001-6138-6961
FU University of Naples Federico II-Ricerca Dip 2017-2018; FIRB-Futuro in
   Ricerca grant from the Italian Ministry of Education, University and
   Research (MIUR) [RBFR12QW4I_004]
FX This work was supported by a grant from the University of Naples
   Federico II-Ricerca Dip 2017-2018 and by a FIRB-Futuro in Ricerca grant
   (RBFR12QW4I_004) from the Italian Ministry of Education, University and
   Research (MIUR).
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NR 54
TC 13
Z9 13
U1 0
U2 5
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD NOV
PY 2019
VL 11
IS 11
AR 2670
DI 10.3390/nu11112670
PG 17
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA JV3OC
UT WOS:000502274600121
PM 31694213
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Murakami, S
   Ono, A
   Kawasaki, A
   Takenaga, T
   Ito, T
AF Murakami, Shigeru
   Ono, Ayuko
   Kawasaki, Azusa
   Takenaga, Takaaki
   Ito, Takashi
TI Taurine attenuates the development of hepatic steatosis through the
   inhibition of oxidative stress in a model of nonalcoholic fatty liver
   disease in vivo and in vitro
SO AMINO ACIDS
LA English
DT Article
DE Taurine; Nonalcoholic fatty liver disease; Oxidative stress; Steatosis;
   HepG2
ID SPONTANEOUSLY HYPERTENSIVE-RATS; HIGH-CHOLESTEROL DIET; BILE-ACID
   PRODUCTION; ANTIOXIDANT ACTIVITY; METABOLIC SYNDROME; OBESITY; MICE;
   HYPERCHOLESTEROLEMIA; STEATOHEPATITIS; IMPROVEMENT
AB Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease. It is characterized by the accumulation of triglyceride within hepatocytes. Taurine is a sulfur-containing-beta-amino acid that is widely distributed in mammalian tissues. The objective of this study was to examine the effects of taurine on the development of hepatic steatosis in a model of NAFLD in vivo and in vitro. Male C57BL/6J mice were fed a high-fat diet (HFD) supplemented with 2% (w/v) or 5% (w/v) taurine for 12 weeks. An in vitro study was performed in HepG2 cells loaded with fatty acids. Twelve weeks of supplementation with an HFD increased the hepatic lipid levels and oxidative stress as well as the body weight and liver weight. Taurine significantly suppressed these changes, which was accompanied by a decrease in the hepatic level of thiobarbituric acid-reactive substances (TBARS). In addition, taurine treatment suppressed the HFD-induced reduction of the enzyme activity of hepatic superoxide dismutase and catalase and the reduction of the hepatic level of reduced glutathione and ATP. In HepG2 cells, taurine suppressed the fatty acid-induced lipid accumulation, production of reactive oxygen species and TBARS level, and amelioration of the fatty acid-induced disruption of the mitochondrial membrane potential. These results showed that taurine was effective in alleviating hepatic steatosis by reducing oxidative stress. Taurine may, therefore, be of therapeutic value in reducing the risks associated with NAFLD.
C1 [Murakami, Shigeru; Ono, Ayuko; Kawasaki, Azusa; Ito, Takashi] Fukui Prefectural Univ, Dept Biosci & Biotechnol, Fukui 9101195, Japan.
   [Takenaga, Takaaki] Kitasato Univ, Clin Trial Coordinating Ctr, Minato Ku, Tokyo 1088643, Japan.
C3 Fukui Prefectural University; Kitasato University
RP Murakami, S (corresponding author), Fukui Prefectural Univ, Dept Biosci & Biotechnol, Fukui 9101195, Japan.
EM murakami@fpu.ac.jp; s1673006@g.fpu.ac.jp; s1673007@g.fpu.ac.jp;
   takena-t@insti.kitasato-u.ac.jp; tito@fpu.ac.jp
RI Ito, Takashi/ABC-2950-2021
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NR 36
TC 52
Z9 59
U1 3
U2 41
PU SPRINGER WIEN
PI WIEN
PA SACHSENPLATZ 4-6, PO BOX 89, A-1201 WIEN, AUSTRIA
SN 0939-4451
EI 1438-2199
J9 AMINO ACIDS
JI Amino Acids
PD SEP
PY 2018
VL 50
IS 9
BP 1279
EP 1288
DI 10.1007/s00726-018-2605-8
PG 10
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA GR4MI
UT WOS:000442584500011
PM 29946793
DA 2025-06-11
ER

PT J
AU Liu, JF
   Liu, YH
   Chen, CM
   Chang, WH
   Chen, CYO
AF Liu, Jen-Fang
   Liu, Yen-Hua
   Chen, Chiao-Ming
   Chang, Wen-Hsin
   Chen, C-Y. Oliver
TI The effect of almonds on inflammation and oxidative stress in Chinese
   patients with type 2 diabetes mellitus: a randomized crossover
   controlled feeding trial
SO EUROPEAN JOURNAL OF NUTRITION
LA English
DT Article
DE Almonds; Antioxidants; Inflammation; Oxidative stress; Type 2 diabetes
   mellitus
ID C-REACTIVE PROTEIN; CARDIOVASCULAR RISK-FACTORS; CORONARY-HEART-DISEASE;
   LIPID-PEROXIDATION; METABOLIC SYNDROME; POSTPRANDIAL GLYCEMIA;
   INSULIN-RESISTANCE; DIET; NUTS; ANTIOXIDANTS
AB Almond consumption is associated with ameliorations in obesity, hyperlipidemia, hypertension, and hyperglycemia. The hypothesis of this 12-week randomized, crossover, controlled feeding trial was that almond consumption would ameliorate inflammation and oxidative stress in Chinese patients with type 2 diabetes mellitus (T2DM) (9 M, 11 F; 58 years; BMI: 26 kg/m(2)) with mild hyperlipidemia.
   After a 2-week run-in period, the patients were assigned to either a control NCEP step II diet (control diet) or almond diet for 4 weeks with a 2-week washout period between alternative diets. Almonds approximately at 56 g/day were added to the control diet to replace 20 % of total daily calorie intake.
   As compared to the control diet, the almond diet decreased IL-6 by a median 10.3 % (95 % confidence intervals 5.2, 12.6 %), CRP by a median 10.3 % (-24.1, 40.5), and TNF-alpha by a median 15.7 % (-0.3, 29.9). The almond diet also decreased plasma protein carbonyl by a median 28.2 % (4.7, 38.2) as compared to the C diet but did not alter plasma malondialdehyde. The A diet enhanced the resistance of LDL against Cu2+-induced oxidation by a median 16.3 % (7.4, 44.3) as compared to the C diet. Serum intercellular adhesion molecule-1 and vascular adhesion molecule-1 were not changed by both diets.
   Our results suggested that incorporation of almonds into a healthy diet could ameliorate inflammation and oxidative stress in patients with T2DM.
C1 [Liu, Jen-Fang; Liu, Yen-Hua; Chang, Wen-Hsin] Taipei Med Univ, Sch Nutr & Hlth Sci, Taipei, Taiwan.
   [Chen, Chiao-Ming] Shih Chien Univ, Dept Food Sci Nutr & Nutraceut Biotechnol, Taipei, Taiwan.
   [Chen, C-Y. Oliver] Tufts Univ, Jean Mayer USDA Human Nutr Res Ctr Aging, Antioxidants Res Lab, Boston, MA 02111 USA.
C3 Taipei Medical University; Shih Chien University; Tufts University;
   United States Department of Agriculture (USDA)
RP Chen, CYO (corresponding author), Tufts Univ, Jean Mayer USDA Human Nutr Res Ctr Aging, Antioxidants Res Lab, 711 Washington St, Boston, MA 02111 USA.
EM oliver.chen@tufts.edu
RI Chen, Chiao-Ming/ABI-7930-2020; Chen, Yung-Chung/GRY-3101-2022
OI Chang, Wen-Hsin/0000-0003-3429-9920
FU Almond Board of California; LEARN weight management foundation in Taiwan
FX We would like to express our gratitude to the Almond Board of California
   and LEARN weight management foundation in Taiwan for providing financial
   supports for the study and the volunteers for participating in the
   clinical trial.
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NR 50
TC 72
Z9 79
U1 1
U2 43
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1436-6207
EI 1436-6215
J9 EUR J NUTR
JI Eur. J. Nutr.
PD APR
PY 2013
VL 52
IS 3
BP 927
EP 935
DI 10.1007/s00394-012-0400-y
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 119DY
UT WOS:000317078900008
PM 22722891
DA 2025-06-11
ER

PT J
AU Barbosa, KBF
   Volp, ACP
   Hermsdorff, HHM
   Navarro-Blasco, I
   Zulet, MA
   Martínez, JA
   Bressan, J
AF Barbosa, Kiriaque B. F.
   Volp, Ana Carolina P.
   Hermsdorff, Helen Hermana M.
   Navarro-Blasco, Inigo
   Zulet, M. Angeles
   Martinez, J. Alfredo
   Bressan, Josefina
TI Relationship of oxidized low density lipoprotein with lipid profile and
   oxidative stress markers in healthy young adults: a translational study
SO LIPIDS IN HEALTH AND DISEASE
LA English
DT Article
ID SERUM URIC-ACID; METABOLIC SYNDROME; SELENIUM INTAKE; LDL; MEN; RISK;
   PLASMA; DISEASE; INFLAMMATION; ASSOCIATION
AB Background: Despite oxidized low density lipoprotein (ox-LDL) plays important roles in the pro-inflammatory and atherosclerotic processes, the relationships with metabolic and oxidative stress biomarkers have been only scarcely investigated in young adult people. Thus, the aim of this study was to assess plasma ox-LDL concentrations and the potential association with oxidative stress markers as well as with anthropometric and metabolic features in healthy young adults.
   Methods: This study enrolled 160 healthy subjects (92 women/68 men; 23 +/- 4 y; 22.0 +/- 2.9 kg/m(2)). Anthropometry, body composition, blood pressure, lifestyle features, biochemical data, and oxidative stress markers were assessed with validated tools. Selenium, copper, and zinc nail concentrations were measured by atomic absorption spectrophotometry.
   Results: Total cholesterol (TC), LDL-c and uric acid concentrations, TC-to-HDL-c ratio, and glutathione peroxidase (GPx) activity were positive predictors of ox-LDL concentrations, while nail selenium level (NSL) was a negative predictor, independently of gender, age, smoking status, physical activity. Those individuals included in the highest tertile of GPx activity (>= 611 nmol/[mL/min]) and of NSL (>= 430 ng/g of nail) had higher and lower ox-LDL concentrations, respectively, independently of the same covariates plus truncal fat or body mass index, and total cholesterol or LDL-c concentrations.
   Conclusions: Ox-LDL concentrations were significantly associated with lipid biomarkers, GPx activity, uric acid concentration, and NSL, independently of different assayed covariates, in young healthy adults. These findings jointly suggest the early and complex relationship between lipid profile and redox status balance.
C1 [Bressan, Josefina] Univ Fed Vicosa, Dept Nutr & Hlth, Vicosa, MG, Brazil.
   [Barbosa, Kiriaque B. F.] Univ Fed Sergipe, Nutr Ctr, Aracaju, Brazil.
   [Volp, Ana Carolina P.] Univ Fed Ouro Preto, Dept Clin & Social Nutr, Ouro Preto, Brazil.
   [Hermsdorff, Helen Hermana M.; Zulet, M. Angeles; Martinez, J. Alfredo] Univ Navarra, Dept Nutr Food Sci Physiol & Toxicol, E-31080 Pamplona, Spain.
   [Navarro-Blasco, Inigo] Univ Navarra, Dept Chem & Soil Sci, E-31080 Pamplona, Spain.
C3 Universidade Federal de Vicosa; Universidade Federal de Sergipe;
   Universidade Federal de Ouro Preto; University of Navarra; University of
   Navarra
RP Bressan, J (corresponding author), Univ Fed Vicosa, Dept Nutr & Hlth, Vicosa, MG, Brazil.
EM jbrm@ufv.br
RI Bressan, Josefina/A-2598-2009; Barbosa, Kiriaque/E-4269-2014; Zulet, M.
   Angeles/H-1317-2017; Hermsdorff, Helen Hermana Miranda/H-4525-2015;
   Navarro-Blasco, Inigo/D-8148-2012; Martinez Hernandez, J
   Alfredo/K-8709-2014
OI Zulet, M. Angeles/0000-0002-3926-0892; Hermsdorff, Helen Hermana
   Miranda/0000-0002-4441-6572; Bressan, Josefina/0000-0002-4993-9436;
   Navarro-Blasco, Inigo/0000-0003-1863-0580; Martinez Hernandez, J
   Alfredo/0000-0001-5218-6941
FU Capes Foundation-Ministry of Education of Brazil; Ministry of Education
   of Spain; University of Vicosa [CAPES/MECD-DGU 109/06]; University of
   Navarra [PHB-2005-0119-PC]; Foundation for Research Support of the State
   of Minas Gerais [FAPEMIG-CDS 303/06]
FX The authors wish to thank Sonia Ribeiro, Sergio de Paula, Leandro de
   Oliveira, and Antonio Carneiro, for technical assistance, Elisangela
   Lessa, Damiana Rosa and Carolina Resende for her help with data
   collection, and all those who volunteered to participate in the study.
   We also thank to The Capes Foundation-Ministry of Education of Brazil as
   well as to Ministry of Education of Spain for the supporting the
   interuniversity cooperation between the University of Vicosa
   (CAPES/MECD-DGU 109/06) and the University of Navarra
   (PHB-2005-0119-PC). Finally, this work was supported by the Foundation
   for Research Support of the State of Minas Gerais (FAPEMIG-CDS 303/06).
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NR 46
TC 21
Z9 22
U1 0
U2 4
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1476-511X
J9 LIPIDS HEALTH DIS
JI Lipids Health Dis.
PD APR 19
PY 2011
VL 10
AR 61
DI 10.1186/1476-511X-10-61
PG 8
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA 774NO
UT WOS:000291393500001
PM 21504598
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Scullion, SM
   Hahn, C
   Tyka, K
   Flatt, PR
   McClenaghan, NH
   Lenzen, S
   Gurgul-Convey, E
AF Scullion, Siobhan M.
   Hahn, Claudine
   Tyka, Karolina
   Flatt, Peter R.
   McClenaghan, Neville H.
   Lenzen, Sigurd
   Gurgul-Convey, Ewa
TI Improved antioxidative defence protects insulin-producing cells against
   homocysteine toxicity
SO CHEMICO-BIOLOGICAL INTERACTIONS
LA English
DT Article
DE Homocysteine; Insulin-producing cells; Antioxidant enzymes; Oxidative
   stress; Alloxan; Diabetes
ID OXIDATIVE STRESS; N-HOMOCYSTEINYLATION; GLUCOSE TOXICITY; RINM5F CELLS;
   MECHANISMS; HYPERHOMOCYSTEINEMIA; OVEREXPRESSION; LIPOTOXICITY;
   THIOLACTONE; PROTEINS
AB Homocysteine (HC) is considered to play an important role in the development of metabolic syndrome complications. Insulin-producing cells are prone to HC toxicity and this has been linked to oxidative stress. However, the exact mechanisms remain unknown. Therefore it was the aim of this study to determine the nature of reactive oxygen species responsible for HC toxicity.
   Chronic exposure of RINm5F and INS1E insulin-producing cells to HC decreased cell viability and glucose induced insulin secretion in a concentration-dependent manner and led to a significant induction of hydrogen peroxide generation in the cytosolic, but not the mitochondria] compartment of the cell. Cytosolic overexpression of catalase, a hydrogen peroxide detoxifying enzyme, provided a significant protection against viability loss and hydrogen peroxide generation, while mitochondria] overexpression of catalase did not protect against HC toxicity. Overexpression of CuZnSOD, a cytosolic superoxide dismutating enzyme, also protected against HC toxicity. However, the best protection was achieved in the case of a combined overexpression of CuZnSOD and catalase. Incubation of cells in combination with alloxan resulted in a significant increase of HC toxicity and an increase of hydrogen peroxide generation. Overexpression of CuZnSOD or catalase protected against the toxicity of HC plus alloxan, with a superior protection achieved again by combined overexpression. The results indicate that HC induces oxidative stress in insulin producing cells by stimulation of superoxide radical and hydrogen peroxide generation in the cytoplasm. The low antioxidative defence status makes the insulin-producing cells very vulnerable to HC toxicity. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
C1 [Scullion, Siobhan M.; Flatt, Peter R.; McClenaghan, Neville H.] Univ Ulster, SAAD Ctr Pharm & Diabet, Diabet Res Grp, Coleraine BT52 1SA, Londonderry, North Ireland.
   [Scullion, Siobhan M.; Hahn, Claudine; Tyka, Karolina; Lenzen, Sigurd; Gurgul-Convey, Ewa] Hannover Med Sch, Inst Clin Biochem, Carl Neuberg Str 1, D-30625 Hannover, Germany.
C3 Ulster University; Hannover Medical School
RP Gurgul-Convey, E (corresponding author), Hannover Med Sch, Inst Clin Biochem, Carl Neuberg Str 1, D-30625 Hannover, Germany.
EM Gurgul-Convey.Ewa@mh-hannover.de
OI Flatt, Peter/0000-0001-8548-7943; Gurgul-Convey,
   Ewa/0000-0002-9269-266X; Tyka, Karolina/0000-0002-4169-1675;
   McClenaghan, Neville/0000-0001-5412-0241
FU Research and Development Office of the Northern Ireland Department for
   Health and Personal Social Services; University of Ulster; European
   Union
FX These studies were supported, in part, by the Research and Development
   Office of the Northern Ireland Department for Health and Personal Social
   Services and the University of Ulster Research strategy funding. SMS was
   recipient of a grant in the Erasmus Programme of the European Union.
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NR 53
TC 4
Z9 4
U1 0
U2 9
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0009-2797
EI 1872-7786
J9 CHEM-BIOL INTERACT
JI Chem.-Biol. Interact.
PD AUG 25
PY 2016
VL 256
BP 37
EP 46
DI 10.1016/j.cbi.2016.06.019
PG 10
WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology
GA DU6RA
UT WOS:000382341100005
PM 27317948
OA Green Submitted, Bronze
DA 2025-06-11
ER

PT J
AU Tomechko, SE
   Liu, GM
   Tao, MF
   Schlatzer, D
   Powell, CT
   Gupta, S
   Chance, MR
   Daneshgari, F
AF Tomechko, Sara E.
   Liu, Guiming
   Tao, Mingfang
   Schlatzer, Daniela
   Powell, C. Thomas
   Gupta, Sanjay
   Chance, Mark R.
   Daneshgari, Firouz
TI Tissue Specific Dysregulated Protein Subnetworks in Type 2 Diabetic
   Bladder Urothelium and Detrusor Muscle
SO MOLECULAR & CELLULAR PROTEOMICS
LA English
DT Article
ID OXIDATIVE STRESS; CARBONYL REDUCTASE; METABOLIC-SYNDROME; MOLECULAR
   TARGETS; RHO GTPASES; MELLITUS; GLUTATHIONE; DYSFUNCTION;
   PHOSPHORYLATION; COMPLICATIONS
AB Diabetes mellitus is well known to cause bladder dysfunction; however, the molecular mechanisms governing this process and the effects on individual tissue elements within the bladder are poorly understood, particularly in type 2 diabetes. A shotgun proteomics approach was applied to identify proteins differentially expressed between type 2 diabetic (TallyHo) and control (SWR/J) mice in the bladder smooth muscle and urothelium, separately. We were able to identify 1760 nonredundant proteins from the detrusor smooth muscle and 3169 nonredundant proteins from urothelium. Pathway and network analysis of significantly dysregulated proteins was conducted to investigate the molecular processes associated with diabetes. This pinpointed ERK1/2 signaling as a key regulatory node in the diabetes-induced pathophysiology for both tissue types. The detrusor muscle samples showed diabetes-induced increased tissue remodeling-type events such as Actin Cytoskeleton Signaling and Signaling by Rho Family GTPases. The diabetic urothelium samples exhibited oxidative stress responses, as seen in the suppression of protein expression for key players in the NRF2-Mediated Oxidative Stress Response pathway. These results suggest that diabetes induced elevated inflammatory responses, oxidative stress, and tissue remodeling are involved in the development of tissue specific diabetic bladder dysfunctions. Validation of signaling dysregulation as a function of diabetes was performed using Western blotting. These data illustrated changes in ERK1/2 phosphorylation as a function of diabetes, with significant decreases in diabetes-associated phosphorylation in urothelium, but the opposite effect in detrusor muscle. These data highlight the importance of understanding tissue specific effects of disease process in understanding pathophysiology in complex disease and pave the way for future studies to better understand important molecular targets in reversing bladder dysfunction.
C1 [Tomechko, Sara E.; Schlatzer, Daniela; Chance, Mark R.] Case Western Reserve Univ, Sch Med, Ctr Prote & Bioinformat, Univ Hosp Case Med Ctr, Cleveland, OH 44106 USA.
   [Liu, Guiming; Tao, Mingfang; Powell, C. Thomas; Gupta, Sanjay; Daneshgari, Firouz] Case Western Reserve Univ, Sch Med, Inst Urol, Univ Hosp Case Med Ctr, Cleveland, OH 44106 USA.
   [Liu, Guiming] Case Western Reserve Univ, Sch Med, Dept Urol, Cleveland, OH 44106 USA.
C3 University System of Ohio; Case Western Reserve University; Case Western
   Reserve University Hospital; University System of Ohio; Case Western
   Reserve University; Case Western Reserve University Hospital; University
   System of Ohio; Case Western Reserve University
RP Liu, GM (corresponding author), Case Western Reserve Univ, Sch Med, Inst Urol, Univ Hosp Case Med Ctr, 10900 Euclid Ave,RTG004, Cleveland, OH 44106 USA.
EM guiming.liu@case.edu
RI Liu, Guiming/AAM-2688-2020
OI Gupta, Sanjay/0000-0002-9492-3249
FU NIH/NIDDK [P20 DK09087, R01 DK083733]
FX This study was supported by NIH/NIDDK Grants P20 DK09087 and R01
   DK083733.
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NR 53
TC 17
Z9 20
U1 0
U2 2
PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3996 USA
SN 1535-9476
EI 1535-9484
J9 MOL CELL PROTEOMICS
JI Mol. Cell. Proteomics
PD MAR
PY 2015
VL 14
IS 3
BP 635
EP 645
DI 10.1074/mcp.M114.041863
PG 11
WC Biochemical Research Methods
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA CC9EP
UT WOS:000350671300016
PM 25573746
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Nikonorov, AA
   Skalnaya, MG
   Tinkov, AA
   Skalny, AV
AF Nikonorov, Alexandr A.
   Skalnaya, Margarita G.
   Tinkov, Alexey A.
   Skalny, Anatoly V.
TI Mutual interaction between iron homeostasis and obesity pathogenesis
SO JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
LA English
DT Review
DE Obesity; Iron; Hypoferremia; Inflammation; Adipose tissue
ID ENDOPLASMIC-RETICULUM STRESS; HIGH-FAT DIET; NF-KAPPA-B; INCREASED
   OXIDATIVE STRESS; ADIPOSE-TISSUE; INSULIN-RESISTANCE; TNF-ALPHA; INDUCED
   INFLAMMATION; HEPCIDIN EXPRESSION; METABOLIC SYNDROME
AB Obesity is identified as an important medical problem. One of the pathologic conditions observed in obesity is systemic iron deficiency and hypoferremia. Along with a large number of studies indicating disturbed iron homeostasis in obesity, recent data indicate a cause effect relationship between iron status and obesity-related pathologies. The primary objective of the article is to consider two aspects of the iron obesity interplay: (1) the mechanisms leading to impaired iron balance, and (2) the pathways of iron participation in obesity-related pathogenesis. While considering disturbance of iron homeostasis in obesity, a number of potential mechanisms of hypoferremia are proposed. At the same time, the inflammation of obesity and obesity-related hepcidin and lipocalin 2 hyperproduction seem to be the most probable reasons of obesity-related hypoferremia. Oversecretion of these proteins leads to iron sequestration in reticuloendothelial system cells. The latter also leads to increased adipose tissue iron content, thus producing preconditions for adverse effects of local iron overload. Being a redox-active metal, iron is capable of inducing oxidative stress as well as endoplasmic reticulum stress, inflammation and adipose tissue endocrine dysfunction. Iron-mediated mechanisms of toxicity may influence aspects of obesity pathogenesis possibly even leading to obesity aggravation. Thus, a mutual interaction between disturbance in iron homeostasis and obesity pathogenesis is proposed. All sides of this interaction should be considered to design new therapeutic approaches to the treatment of disturbed iron homeostasis in obesity. (C) 2014 Elsevier GmbH. All rights reserved.
C1 [Nikonorov, Alexandr A.; Tinkov, Alexey A.] Orenburg State Med Acad, Dept Biochem, Orenburg 460000, Russia.
   [Skalnaya, Margarita G.; Skalny, Anatoly V.] Russian Soc Trace Elements Med, Moscow 105064, Russia.
   [Skalny, Anatoly V.] Orenburg State Univ, UNESCO, Russian Satellite Ctr, Inst Bioelementol,Trace Element Inst, Orenburg 460352, Russia.
C3 Orenburg State University
RP Nikonorov, AA (corresponding author), Orenburg State Med Acad, Dept Biochem, Sovetskaya St 6, Orenburg 460000, Russia.
EM alalnikonorov@gmail.com
RI Skalny, Anatoly/J-3953-2019; Tinkov, Alexey/H-5842-2016; Skalny,
   Anatolij Viktorovich/F-2906-2015
OI Nikonorov, Alexandr/0000-0001-7214-8176; Tinkov,
   Alexey/0000-0003-0348-6192; Skalny, Anatolij
   Viktorovich/0000-0002-4185-6783; Skalny, Anatoly/0000-0001-7838-1366;
   Skalnaya, Margarita/0000-0003-1099-2560
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NR 154
TC 55
Z9 62
U1 0
U2 31
PU ELSEVIER GMBH
PI MUNICH
PA HACKERBRUCKE 6, 80335 MUNICH, GERMANY
SN 0946-672X
J9 J TRACE ELEM MED BIO
JI J. Trace Elem. Med. Biol.
PY 2015
VL 30
BP 207
EP 214
DI 10.1016/j.jtemb.2014.05.005
PG 8
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA CE4LL
UT WOS:000351802000033
PM 24916791
DA 2025-06-11
ER

PT J
AU Fukui, T
   Yamauchi, K
   Maruyama, M
   Yasuda, T
   Kohno, M
   Abe, Y
AF Fukui, Toshiki
   Yamauchi, Kazuhiro
   Maruyama, Mie
   Yasuda, Tadashi
   Kohno, Masakazu
   Abe, Youichi
TI Significance of measuring oxidative stress in lifestyle-related diseases
   from the viewpoint of correlation between d-ROMs and BAP in Japanese
   subjects
SO HYPERTENSION RESEARCH
LA English
DT Article
DE BAP; C-reactive protein; d-ROMs; oxidative stress; visceral fat
ID CARDIOVASCULAR-DISEASE; INFLAMMATION; RISK; ANTIOXIDANT; PROTECTION;
   MARKER; ACID
AB In recent years, oxidative stress has been postulated to be an important factor in the pathogenesis and development of lifestyle-related diseases. In this study, we investigated the association between the derivatives of reactive oxygen metabolites (d-ROMs), as an index of products of reactive oxygen species (ROS), and biological antioxidant potential (BAP), as an index of antioxidant potential. We also investigated the associations between d-ROMs or BAP and the risk factors for lifestyle-related diseases or metabolic syndrome-associated factors to evaluate their usefulness in preventive medicine. There were 442 subjects who underwent health checkup examination in our facilities. In addition to standard medical checkup items, we analyzed d-ROMs, BAP, brachial-ankle pulse wave velocity, high-sensitivity C-reactive protein level and visceral fat area (VFA) visualized on a computed tomography scan. The mean d-ROM value in females was significantly higher than that in males. There was a positive correlation between the d-ROM and VFA levels. On correlation analysis, there was a negative correlation between the d-ROM and creatinine levels. As factors that influence d-ROMs, the level of VFA was selected, suggesting the significance of oxidative stress measurement with d-ROMs. In addition, there was a positive correlation between d-ROMs and BAP values. Further research is required to resolve whether increased production of ROS or the antioxidant potential that can compensate for such an increase of ROS is more important in vivo. Hypertension Research (2011) 34, 1041-1045; doi: 10.1038/hr.2011.76; published online 16 June 2011
C1 [Fukui, Toshiki; Yamauchi, Kazuhiro; Maruyama, Mie; Yasuda, Tadashi; Abe, Youichi] NTT W Takamatsu Hosp, Ctr Prevent Med Treatment, Takamatsu, Kagawa, Japan.
   [Kohno, Masakazu] Kagawa Univ, Sch Med, Dept Cardiorenal & Cerebrovasc Internal Med, Takamatsu, Kagawa 760, Japan.
C3 Kagawa University
RP Fukui, T (corresponding author), NTT W Takamatsu Hosp, Ctr Prevent Med Treatment, Takamatsu, Kagawa, Japan.
EM ftoshi@kagawa.west.ntt.co.jp
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NR 28
TC 94
Z9 96
U1 0
U2 5
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0916-9636
EI 1348-4214
J9 HYPERTENS RES
JI Hypertens. Res.
PD SEP
PY 2011
VL 34
IS 9
BP 1041
EP 1045
DI 10.1038/hr.2011.76
PG 5
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 817VZ
UT WOS:000294706000015
PM 21677660
OA Bronze
DA 2025-06-11
ER

PT J
AU Alenazi, AM
   Alshehri, MM
   Alothman, S
   Alqahtani, BA
   Rucker, J
   Sharma, N
   Segal, NA
   Bindawas, SM
   Kluding, PM
AF Alenazi, Aqeel M.
   Alshehri, Mohammed M.
   Alothman, Shaima
   Alqahtani, Bader A.
   Rucker, Jason
   Sharma, Neena
   Segal, Neil A.
   Bindawas, Saad M.
   Kluding, Patricia M.
TI The Association of Diabetes with Knee Pain Severity and Distribution in
   People with Knee Osteoarthritis using Data from the Osteoarthritis
   Initiative
SO SCIENTIFIC REPORTS
LA English
DT Article
ID EARLY POSTOPERATIVE OUTCOMES; OLDER-ADULTS; METABOLIC SYNDROME;
   RISK-FACTOR; OBESITY; HEALTH; PROGRESSION; POPULATION; DEPRESSION;
   ARTHRITIS
AB Limited research has examined the association between diabetes mellitus (DM) and knee pain in people with osteoarthritis (OA). Therefore, this study aimed at examining the association between DM and knee pain severity, and to explore the association between DM and knee pain distribution (unilateral or bilateral versus no pain) in subjects with knee OA. This is a cross-sectional analysis of the baseline visit of individuals who were enrolled in the Osteoarthritis Initiative. Data of participants with knee OA were used for this analysis (n = 1319), and grouped into subjects with both knee OA and DM (n = 148) or knee OA only without DM (n = 1171). Pain severity was measured using a numeric rating scale from 0 to 10 over the past 7 and 30 days for each knee, and the more symptomatic knee with higher pain severity was chosen for analysis. DM was significantly associated with increased knee pain severity over 7 days (B 0.68; 95% CI 0.25-1.11) and over 30 days (B 0.59; 95% CI 0.17-1.01) after adjustments for all covariates, including age, gender, BMI, race, depression symptoms, composite OA score, use of pain medications, and knee injections. Multinomial regression showed that participants with knee OA and DM had 2.45 (95% CI 1.07-5.61) to 2.55 (95% CI 1.12-5.79) times higher likelihood of having unilateral and bilateral knee pain than those without DM and without knee pain. This study found that DM was associated with higher pain severity and unilateral and bilateral knee pain distribution.
C1 [Alenazi, Aqeel M.; Alqahtani, Bader A.] Prince Sattam Bin Abdulaziz Univ, Dept Rehabil Sci & Phys Therapy, Alkharj, Saudi Arabia.
   [Alenazi, Aqeel M.; Alshehri, Mohammed M.; Alothman, Shaima; Rucker, Jason; Sharma, Neena; Kluding, Patricia M.] Univ Kansas, Med Ctr, Dept Phys Therapy & Rehabil Sci, Kansas City, KS 66103 USA.
   [Alshehri, Mohammed M.] Jazan Univ, Dept Rehabil Sci, Jazan, Saudi Arabia.
   [Segal, Neil A.] Univ Kansas, Med Ctr, Dept Rehabil Med, Kansas City, KS 66103 USA.
   [Bindawas, Saad M.] King Saud Univ, Dept Rehabil Sci, Riyadh, Saudi Arabia.
C3 Prince Sattam Bin Abdulaziz University; University of Kansas; University
   of Kansas Medical Center; Jazan University; University of Kansas;
   University of Kansas Medical Center; King Saud University
RP Alenazi, AM (corresponding author), Prince Sattam Bin Abdulaziz Univ, Dept Rehabil Sci & Phys Therapy, Alkharj, Saudi Arabia.; Alenazi, AM (corresponding author), Univ Kansas, Med Ctr, Dept Phys Therapy & Rehabil Sci, Kansas City, KS 66103 USA.
EM aqeelalenazi.pt@gmail.com
RI Alenazi, Aqeel/L-3102-2019; Alothman, Shaima/AAR-9567-2021; Kluding,
   Patricia/D-1617-2016; Segal, Neil/B-2049-2008; Bindawas,
   Saad/D-7815-2013; Alqahtani, Bader/V-8094-2019; Alshehri,
   Mohammed/AFM-1005-2022
OI Alenazi, Aqeel/0000-0002-2641-8339; Bindawas, Saad
   M./0000-0001-8334-2054; Alothman, Shaima/0000-0003-2739-0929; Alqahtani,
   Bader/0000-0002-8275-6906; Alshehri, Mohammed/0000-0003-0028-0957
FU National Institutes of Health, a branch of the Department of Health and
   Human Services [N01-AR-2-2258, N01-AR-2-2259, N01-AR-2-2260,
   N01-AR-2-2261, N01-AR-2-2262]; Merck Research Laboratories; Novartis
   Pharmaceuticals Corporation; GlaxoSmithKline; Pfizer, Inc.; Foundation
   for the National Institutes of Health
FX The OAI is a public-private partnership comprised of five contracts
   (N01-AR-2-2258; N01-AR-2-2259; N01-AR-2-2260; N01-AR-2-2261;
   N01-AR-2-2262) funded by the National Institutes of Health, a branch of
   the Department of Health and Human Services, and conducted by the OAI
   Study Investigators. Private funding partners include Merck Research
   Laboratories; Novartis Pharmaceuticals Corporation, GlaxoSmithKline; and
   Pfizer, Inc. Private sector funding for the OAI is managed by the
   Foundation for the National Institutes of Health. This manuscript was
   prepared using an OAI public use data set and does not necessarily
   reflect the opinions or views of the OAI investigators, the NIH, or the
   private funding partners. All authors would like to thank Prince Sattam
   Bin Abdulaziz University. Part of this work has been published as an
   abstract at Journal of Orthopedic and Sports Physical Therapy for the
   Combined Section Meeting, American Physical Therapy Association, New
   Orleans, LA, February 21-24, 2018.
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NR 47
TC 27
Z9 28
U1 1
U2 5
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD MAR 4
PY 2020
VL 10
IS 1
AR 3985
DI 10.1038/s41598-020-60989-1
PG 8
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA NF4MC
UT WOS:000563271000016
PM 32132621
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Hintz, KK
   Aberle, NS
   Ren, J
AF Hintz, KK
   Aberle, NS
   Ren, J
TI Insulin resistance induces hyperleptinemia, cardiac contractile
   dysfunction but not cardiac leptin resistance in ventricular myocytes
SO INTERNATIONAL JOURNAL OF OBESITY
LA English
DT Article
DE insulin resistance; leptin; myocyte; shortening; intracellular Ca2+
   transients
ID NITRIC-OXIDE; HYPERTENSION; OBESITY; PRESSURE; INFUSION; NO
AB Insulin resistance is a metabolic syndrome commonly seen in obesity. Leptin, the obese gene product, plays a role in the regulation of cardiac function. Elevated leptin levels have been demonstrated under insulin-resistant states such as obesity and hypertension, although their role in cardiac dysfunction is unknown. This study was designed to determine the impact of prediabetic insulin resistance on leptin levels and leptin-induced cardiac contractile response. Whole-body insulin resistance was generated with a 10-week dietary sucrose feeding. Contractile and intracellular Ca2+ properties were evaluated in ventricular myocytes using an IonOptix(TM) system. The contractile indices analyzed included peak shortening ( PS), time-to-PS (TPS), time-to-90% relengthening (TR90), maximal velocity of shortening/ relengthening (+/-dL/dt), fura-fluorescence intensity change (DeltaFFI) and decay rate (tau). Sucrose-fed rats displayed significantly elevated body weight and plasma leptin levels, depressed PS, +/-dL/dt, shortened TPS, prolonged TR90 and t, as well as reduced DFFI compared to the starch-fed control group. Leptin (1 - 1000 nM) elicited a concentration-dependent depression of PS and DFFI in myocytes from both starch and sucrose groups. Leptin-induced contractile depression was abolished by the nitric oxide synthase inhibitor Nomega-nitro-L-arginine methyle ester, elevation of the extracellular Ca2+ concentration, the Janus activated kinase 2 inhibitor AG-490 or the mitogen activated protein kinase inhibitor SB203580 in myocytes from both sucrose and starch groups. Moreover, AG-490 and SB203580 unmasked a positive response of PS in myocytes from both groups. These data indicate that insulin resistance directly induces hyperleptinemia and cardiac contractile dysfunction, without affecting leptin-mediated cardiac contractile function at the myocyte level.
C1 Univ N Dakota, Sch Med & Hlth Sci, Dept Pharmacol Physiol & Therapeut, Grand Forks, ND 58201 USA.
C3 University of North Dakota Grand Forks
RP Ren, J (corresponding author), Univ Wyoming, Coll Hlth Sci, Div Pharmaceut Sci, POB 3375, Laramie, WY 82071 USA.
RI Ren, Jun/ACG-5366-2022
OI Ren, Jun/0000-0002-0275-0783
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NR 26
TC 56
Z9 63
U1 0
U2 4
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0307-0565
J9 INT J OBESITY
JI Int. J. Obes.
PD OCT
PY 2003
VL 27
IS 10
BP 1196
EP 1203
DI 10.1038/sj.ijo.0802389
PG 8
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 726WR
UT WOS:000185625000006
PM 14513067
DA 2025-06-11
ER

PT J
AU Barragán-Zarate, GS
   Alexander-Aguilera, A
   Lagunez-Rivera, L
   Solano, R
   Soto-Rodríguez, I
AF Barragan-Zarate, Gabriela Soledad
   Alexander-Aguilera, Alfonso
   Lagunez-Rivera, Luicita
   Solano, Rodolfo
   Soto-Rodriguez, Ida
TI Bioactive compounds from Prosthechea karwinskii decrease obesity,
   insulin resistance, pro-inflammatory status, and cardiovascular risk in
   Wistar rats with metabolic syndrome
SO JOURNAL OF ETHNOPHARMACOLOGY
LA English
DT Article
DE Orchid; UPLC-ESI-qTOF-MS/MS; Hypotriglyceridemic; HS-CRP; Adiponectin;
   TNF-alpha; HOMA-IR
ID C-REACTIVE PROTEIN; OXIDATIVE STRESS; CHLOROGENIC ACID; ADIPOSE-TISSUE;
   ADIPONECTIN; ASSOCIATION; SENSITIVITY; EMBELIN; FAT; MECHANISMS
AB Ethnopharmacological relevance: The orchid Prosthechea karwinskii is a species endemic to Mexico, which is used in traditional medicine to lower glucose levels in patients with diabetes, and to treat inflammation-related problems. Recent studies have shown that this orchids can reduce glucose, cholesterol, and triglyceride levels in Wistar rats, which were previously induced to have metabolic syndrome (MS).
   Aim of the study: To evaluate the effect of P. karwinskii leaves extract on the components of metabolic syndrome: obesity, insulin resistance, pro-inflammatory status, and cardiovascular risk in a Wistar rat model, and to identify the bioactive compounds in the extract.
   Materials and methods: UPLC-ESI-qTOF-MS/MS was used to identify the compounds present in the extract. MS was induced in Wistar rats through administration of a 40% sucrose diet for 20 weeks. The rats were divided into five groups that received different treatments for 4 weeks: one group without any treatment, one group receiving metformin (200 mg/kg p.o.), and three groups receiving different doses of P. karwinskii leaves extract (100, 200, and 300 mg/kg p.o.). The animals' body weights were recorded weekly, and at the end of the experiment, they were sacrificed after fasting for 18 h to determine the levels of glucose, insulin, insulin resistance index, total cholesterol, triglycerides, and adiponectin in the serum, as well as levels of TNF-alpha and HS-CRP in the serum and liver homogenates. The abdominal and pericardial fat weights were also recorded.
   Results: The main bioactive compounds of the extract were quinic acid, neochlorogenic acid, chlorogenic acid, rutin, kaempferol-3-o-beta-rutinoside, and embelin, known to exhibit MS-related bioactivity. Oral administration of P. karwinskii leaves extract at a dose of 300 mg/kg decreased weight gain, abdominal and pericardial fat deposits, and insulin resistance. At the end of the treatment, levels of triglycerides, TNF-alpha, HS-CRP, and adiponectin returned to levels similar to normal.
   Conclusion: P. karwinskii extract (300 mg/kg) had an anti-obesity effect, decreased insulin resistance, pro inflammatory status, and cardiovascular risk in rats with induced MS by increasing adiponectin levels and decreasing TNF-alpha and HS-CRP levels. The compounds identified in the extract could be responsible for these effects, acting alone or in synergy, as several compounds in the extract are known to have MS-related bioactivity. The foliar extract of P. karwinskii has potential as an effective alternative to a cocktail of drugs used to treat problems associated with MS.
C1 [Barragan-Zarate, Gabriela Soledad; Lagunez-Rivera, Luicita; Solano, Rodolfo] Inst Politecn Nacl, Ctr Interdisciplinario Invest Desarrollo Integral, Lab Extracc & Anal Prod Nat Vegetales, Hornos 1003 Santa Cruz Xoxocotlan, Oaxaca 71230, Oaxaca, Mexico.
   [Alexander-Aguilera, Alfonso; Soto-Rodriguez, Ida] Univ Veracruzana, Fac Bioanal, Carmen Serdan S-N,Flores Magon, Veracruz 91700, Veracruz, Mexico.
   [Alexander-Aguilera, Alfonso] Univ Cristobal Colon, Escuela Med, Carretera Veracruz Medellin S-N,Col Puente Moreno, Boca Del Rio 94271, Veracruz, Mexico.
C3 Instituto Politecnico Nacional - Mexico; Universidad Veracruzana
RP Lagunez-Rivera, L (corresponding author), Inst Politecn Nacl, Ctr Interdisciplinario Invest Desarrollo Integral, Lab Extracc & Anal Prod Nat Vegetales, Hornos 1003 Santa Cruz Xoxocotlan, Oaxaca 71230, Oaxaca, Mexico.
EM gabybarraganzarate@hotmail.com; aalexander_2000@yahoo.com;
   llagunez@ipn.mx; solanogo@yahoo.com.mx; isoto@uv.mx
RI Alexander-Aguilera, Alfonso/AAH-9203-2019; Barragán Zarate,
   Gabriela/AAC-3480-2021; LAGUNEZ RIVERA, LUICITA/HZH-8241-2023;
   Solano-Gomez, Rodolfo/F-1183-2018
OI LAGUNEZ RIVERA, LUICITA/0000-0001-9870-971X; Barragan Zarate, Gabriela
   Soledad/0000-0001-7046-4001; Solano-Gomez, Rodolfo/0000-0002-0355-5496
FU CONACYT (Consejo Nacional de Ciencia y Tecnologia) [270428]; Instituto
   Politecnico Nacional (IPN) [SIP20161270, SIP-2016RE/50, SIP-20170263,
   SIP-20180451, SIP20180382]
FX We would like to thank CONACYT (Consejo Nacional de Ciencia y
   Tecnologia) for financial support to project 270428 and the Instituto
   Polit ' ecnico Nacional (IPN) for the financial support to projects
   SIP20161270, SIP-2016RE/50, SIP-20170263, SIP-20180451, and SIP20180382.
   The grants were awarded to Ph.D. students. The committee organized the
   Easter celebrations of the Villa de Zaachila in Oaxaca, Mexico, who
   facilitated the recuperation of the exemplars from the churches.
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NR 53
TC 8
Z9 8
U1 0
U2 23
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0378-8741
EI 1872-7573
J9 J ETHNOPHARMACOL
JI J. Ethnopharmacol.
PD OCT 28
PY 2021
VL 279
AR 114376
DI 10.1016/j.jep.2021.114376
EA JUL 2021
PG 10
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA UA4FL
UT WOS:000685116600004
PM 34181956
DA 2025-06-11
ER

PT J
AU Saeed, S
   Vegsundvåg, J
AF Saeed, Sahrai
   Vegsundvag, Johnny
TI Usefulness of Stress Echocardiography in Assessment of Dynamic Left
   Ventricular Obstructions: Case Series and Review of the Literature
SO CARDIOLOGY
LA English
DT Review
DE Angina pectoris; Dynamic left ventricular outflow tract obstruction;
   Dobutamine stress echocardiography; Left ventricular function; Systolic
   anterior motion
ID OUTFLOW TRACT OBSTRUCTION; BETA-BLOCKER THERAPY; NORMAL CORONARY
   ANGIOGRAM; SYSTOLIC ANTERIOR MOTION; CARDIAC SYNDROME-X; HYPERTROPHIC
   CARDIOMYOPATHY; MIDVENTRICULAR OBSTRUCTION; EXERCISE ECHOCARDIOGRAPHY;
   POTENTIAL CAUSE; MITRAL-VALVE
AB Dynamic left ventricular outflow tract obstruction (DLVOTO) or midcavity obstruction in patients with structurally normal hearts is not uncommon in routine clinical practice and can cause significant symptoms mimicking coronary artery disease or heart failure. Although exercise echocardiography is the gold standard for assessing DLVOTO, dobutamine stress echocardiography (DSE) may be valuable diagnostic modality in patients who are unable to exercise or have an uninterpretable 12-lead electrocardiogram. We provide an updated overview of the relevant literature regarding prevalence, pathophysiology, clinical significance, and prognostic impact of DLVOTO and midcavity obstruction in structurally normal hearts. We also present a clinical series of 4 cases of DLVOTO and midcavity obstruction documented by DSE and discuss the value of different kinds of modern stress imaging modalities involving: (1) contrast-enhanced DSE to assess myocardial perfusion and inducible ischemia; (2) adenosine stress echocardiography to assess coronary flow reserve/microvascular dysfunction; and (3) functional imaging with deformation echocardiography to assess subclinical myocardial dysfunction in patients with structurally normal heart and without significant coronary disease. Based upon our own experiences and a critical review of the current literature, we will then present a practical guidance for management of DLVOTO and midcavity obstruction.
C1 [Saeed, Sahrai] Haukeland Hosp, Dept Heart Dis, Bergen, Norway.
   [Vegsundvag, Johnny] Alesund Hosp, Dept Internal Med, Alesund, Norway.
C3 University of Bergen; Haukeland University Hospital
RP Vegsundvåg, J (corresponding author), Alesund Hosp, Dept Internal Med, Alesund, Norway.
EM johnnyvegsundvag@mimer.no
OI Saeed, Sahrai/0000-0003-4041-5019
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NR 33
TC 7
Z9 7
U1 0
U2 7
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0008-6312
EI 1421-9751
J9 CARDIOLOGY
JI Cardiology
PD JUL
PY 2021
VL 146
IS 4
BP 441
EP 450
DI 10.1159/000516188
EA MAY 2021
PG 10
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA TM1UT
UT WOS:000652268000001
PM 34004597
DA 2025-06-11
ER

PT J
AU Apaiajai, N
   Chunchai, T
   Jaiwongkam, T
   Kerdphoo, S
   Chattipakorn, SC
   Chattipakorn, N
AF Apaiajai, Nattayaporn
   Chunchai, Titikorn
   Jaiwongkam, Thidarat
   Kerdphoo, Sasiwan
   Chattipakorn, Siriporn C.
   Chattipakorn, Nipon
TI Testosterone Deprivation Aggravates Left-Ventricular Dysfunction in Male
   Obese Insulin-Resistant Rats via Impairing Cardiac Mitochondrial
   Function and Dynamics Proteins
SO GERONTOLOGY
LA English
DT Article
DE Testosterone deprivation; Obesity-related insulin resistance; Cardiac
   function; Mitochondrial function; Mitochondrial dynamics proteins
ID HEART-RATE-VARIABILITY; SYMPATHETIC-NERVOUS-SYSTEM;
   MYOCARDIAL-INFARCTION; CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME;
   OXIDATIVE STRESS; FUSION; FAILURE; FISSION; STIMULATION
AB Background: We have previously reported that testosterone deprivation at a very young age accelerated, but did not aggravate, left-ventricular (LV) dysfunction in obese insulin-resistant rats. However, the effects of testosterone deprivation during adulthood on LV function in obese insulin-resistant rats remains unclear. We hypothesized that testosterone deprivation aggravates LV dysfunction and cardiac autonomic imbalance via the impairment of cardiac mitochondrial function and dynamics proteins, a reduction in insulin receptor function, and an increase in apoptosis in obese insulin-resistant rats. Methods: Male rats were fed on either a normal diet (ND) or a high-fat diet (HFD) for 12 weeks. They were then subdivided into 2 groups: sham operation (NDS, HFS) and orchiectomy (NDO, HFO). Metabolic parameters, blood pressure, heart rate variability (HRV), and LV function were determined at baseline and before and after orchiectomy. Mitochondrial function and dynamics proteins, insulin signaling, and apoptosis were determined 12 weeks postoperatively. Results: HFS rats exhibited obese insulin resistance, depressed HRV, and LV dysfunction. In HFO rats, systolic blood pressure was increased with more excessive depression of HRV and increased LV dysfunction, compared with HFS rats. These adverse cardiac effects were consistent with markedly increased mitochondrial dysfunction, reduced mitochondrial complex I and III proteins, reduced mitochondrial fusion proteins, and increased apoptosis, compared with HFS rats. However, testosterone deprivation did not lead to any alteration in the insulin-resistant condition in HFO rats, compared with HFS rats. Conclusion: We concluded that testosterone deprivation during adulthood aggravated the impairment of mitochondrial function, mitochondrial respiratory complex, mitochondrial dynamics proteins, and apoptosis, leading to LV dysfunction in obese insulin-resistant rats. (C) 2018 S. Karger AG, Basel
C1 [Apaiajai, Nattayaporn; Chunchai, Titikorn; Jaiwongkam, Thidarat; Kerdphoo, Sasiwan; Chattipakorn, Siriporn C.; Chattipakorn, Nipon] Chiang Mai Univ, Cardiac Electrophysiol Res & Training Ctr, Fac Med, 110 Intawaroros Rd, Chiang Mai 50200, Thailand.
   [Apaiajai, Nattayaporn; Chunchai, Titikorn; Jaiwongkam, Thidarat; Kerdphoo, Sasiwan; Chattipakorn, Siriporn C.; Chattipakorn, Nipon] Chiang Mai Univ, Ctr Excellence Cardiac Electrophysiol Res, Chiang Mai, Thailand.
   [Chunchai, Titikorn; Chattipakorn, Nipon] Chiang Mai Univ, Dept Physiol, Cardiac Electrophysiol Unit, Fac Med, Chiang Mai, Thailand.
   [Chattipakorn, Siriporn C.] Chiang Mai Univ, Fac Dent, Dept Oral Biol & Diagnost Sci, Chiang Mai, Thailand.
C3 Chiang Mai University; Chiang Mai University; Chiang Mai University;
   Chiang Mai University
RP Chattipakorn, N (corresponding author), Chiang Mai Univ, Cardiac Electrophysiol Res & Training Ctr, Fac Med, 110 Intawaroros Rd, Chiang Mai 50200, Thailand.
EM nchattip@gmail.com
RI Chattipakorn, Nipon/AAJ-4049-2021
OI Chunchai, Titikorn/0000-0003-4405-1208; Chattipakorn,
   Siriporn/0000-0003-1677-7052
FU Thailand Research Fund [TRF-RTA6080003, TRG6080005]; Royal Golden
   Jubilee Program; NSTDA Research Chair grant from the National Science
   and Technology Development Agency Thailand; Faculty of Medicine, Chiang
   Mai University Endowment Fund [131/2559]
FX This work was supported by Thailand Research Fund grants TRF-RTA6080003
   (S.C.C.), TRG6080005 (N.A.), and the Royal Golden Jubilee Program (T.C.
   and S.C.C.), an NSTDA Research Chair grant from the National Science and
   Technology Development Agency Thailand (N.C.), and Faculty of Medicine,
   Chiang Mai University Endowment Fund 131/2559 (N.A.).
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NR 39
TC 24
Z9 25
U1 0
U2 1
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0304-324X
EI 1423-0003
J9 GERONTOLOGY
JI Gerontology
PY 2018
VL 64
IS 4
BP 333
EP 343
DI 10.1159/000487188
PG 11
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA GJ6JO
UT WOS:000435490400004
PM 29566382
OA Bronze
DA 2025-06-11
ER

PT J
AU Al-Eisa, ES
   Alghadir, AH
   Gabr, SA
AF Al-Eisa, Einas S.
   Alghadir, Ahmad H.
   Gabr, Sami A.
TI Correlation between vitamin D levels and muscle fatigue risk factors
   based on physical activity in healthy older adults
SO CLINICAL INTERVENTIONS IN AGING
LA English
DT Article
DE exercise; physical fitness; muscle stress; oxidative stress; 25(OH)D
   concentrations; troponin I; hydroxyproline
ID TOTAL ANTIOXIDANT CAPACITY; SERUM 25-HYDROXYVITAMIN D; RANDOMIZED
   CONTROLLED-TRIAL; BONE-MINERAL DENSITY; SKELETAL-MUSCLE; OXIDATIVE
   STRESS; D DEFICIENCY; INSULIN-RESISTANCE; METABOLIC SYNDROME; ACTIVITY
   QUESTIONNAIRE
AB Purpose: The purpose of this study was to investigate the relationship of serum vitamin D levels with physical activity, obesity, muscle fatigue biomarkers, and total antioxidant capacity (TAC) in healthy older adults.
   Methods: A total of 85 healthy older subjects aged 64-96 years were recruited in this study. Based on estimated energy expenditure scores, the participants were classified into three groups: inactive (n=25), moderate (n=20), and physically active (n=35). Serum 25(OH) D (25-hydroxy vitamin D) levels, metabolic syndrome parameters, TAC activity, muscle fatigue biomarkers (Ca, creatine kinase, lactic acid dehydrogenase, troponin I, hydroxyproline), physical activity, body fatness, and fatigue score (visual analog scale) were estimated using immunoassay techniques and prevalidated questionnaires, respectively.
   Results: Physical activity was estimated in 64.6% of the participants. Males showed higher physical activity (42.5%) compared to females (26.25%). Compared to participants with lower activity, significant reduction in body mass index, waist circumference, hips, fasting blood sugar, triglycerides, total cholesterol, HDL-cholesterol, and LDL-cholesterol were observed in moderate and physically active participants. Also, significant increase in the levels of serum 25(OH)D concentrations, calcium, and TAC activity along with reduction in the levels of muscle fatigue biomarkers: creatine kinase, lactic acid dehydrogenase, troponin I, hydroxyproline, and fatigue scores (visual analog scale) were reported in physically active participants compared to those of lower physical activity. In all participants, serum 25(OH)D concentrations correlated positively with Ca, TAC, physical activity scores, and negatively with body mass index, lipid profile, fatigue scores (visual analog scale), and muscle fatigue biomarkers. Stepwise regression analysis showed that serum 25(OH)D concentrations, physical activity, Ca, TAC, and demographic parameters explained approximately 61.4%-85.8% of reduction in both fatigue scores and muscle fatigue biomarkers with substantial improvement in muscle performance in healthy older adults.
   Conclusion: The data showed that considerable levels of 25(OH)D concentrations, calcium intake, and lower obesity positively correlated with the improvement in the muscle relief and performance of physically active participants. These results demonstrate that 25(OH)D concentrations and calcium might prevent muscle fatigue by regulation of the biosynthesis of creatine kinase, lactic acid dehydrogenase, troponin I, and hydroxyproline via a proposed antifree radical mechanism reported by higher TAC activity. It was suggested that vitamin D status could be reported as a marker of the improvement of muscle performance, especially in healthy older adults with lower physical activity.
C1 [Al-Eisa, Einas S.; Alghadir, Ahmad H.; Gabr, Sami A.] King Saud Univ, Coll Appl Med Sci, Ehabilitat Res Chair, POB 10219, Riyadh 11433, Saudi Arabia.
   [Gabr, Sami A.] Mansoura Univ, Dept Anat, Fac Med, Mansoura, Egypt.
C3 King Saud University; Egyptian Knowledge Bank (EKB); Mansoura University
RP Gabr, SA (corresponding author), King Saud Univ, Coll Appl Med Sci, Ehabilitat Res Chair, POB 10219, Riyadh 11433, Saudi Arabia.
EM sgabr@ksu.edu.sa
RI Alghadir, Ahmad H./HKO-9206-2023; Gabr, Sami A./AAC-4594-2019
OI Alghadir, Ahmad H./0000-0002-1204-476X; Gabr, Sami
   A./0000-0003-4965-5852
FU King Saud University, through Vice Deanship of Research Chairs,
   Rehabilitation Research Chair
FX The Project was fully financially supported by King Saud University,
   through Vice Deanship of Research Chairs, Rehabilitation Research Chair.
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NR 96
TC 44
Z9 45
U1 0
U2 4
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-1998
J9 CLIN INTERV AGING
JI Clin. Interv. Aging
PY 2016
VL 11
BP 513
EP 522
DI 10.2147/CIA.S102892
PG 10
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA DL3QP
UT WOS:000375548600001
PM 27217733
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU McCarty, MF
   DiNicolantonio, JJ
AF McCarty, Mark F.
   DiNicolantonio, James J.
TI Maintaining Effective Beta Cell Function in the Face of Metabolic
   Syndrome-Associated Glucolipotoxicity-Nutraceutical Options
SO HEALTHCARE
LA English
DT Article
DE type 2 diabetes; glucolipotoxicity; beta cells; GSIS; PDX1; JNK; GLP-1;
   nutraceuticals; pre-biotics; pro-biotics
ID ALPHA-LIPOIC ACID; INSULIN-RECEPTOR SUBSTRATE-2; IMPAIRED
   GLUCOSE-TOLERANCE; ACTIVATED PROTEIN-KINASE; NADPH OXIDASE NOX2;
   HIGH-FAT DIET; OXIDATIVE STRESS; BIOTIN SUPPLEMENTATION; INDUCED
   APOPTOSIS; HEME OXYGENASE-1
AB In people with metabolic syndrome, episodic exposure of pancreatic beta cells to elevated levels of both glucose and free fatty acids (FFAs)-or glucolipotoxicity-can induce a loss of glucose-stimulated insulin secretion (GSIS). This in turn can lead to a chronic state of glucolipotoxicity and a sustained loss of GSIS, ushering in type 2 diabetes. Loss of GSIS reflects a decline in beta cell glucokinase (GK) expression associated with decreased nuclear levels of the pancreatic and duodenal homeobox 1 (PDX1) factor that drives its transcription, along with that of Glut2 and insulin. Glucolipotoxicity-induced production of reactive oxygen species (ROS), stemming from both mitochondria and the NOX2 isoform of NADPH oxidase, drives an increase in c-Jun N-terminal kinase (JNK) activity that promotes nuclear export of PDX1, and impairs autocrine insulin signaling; the latter effect decreases PDX1 expression at the transcriptional level and up-regulates beta cell apoptosis. Conversely, the incretin hormone glucagon-like peptide-1 (GLP-1) promotes nuclear import of PDX1 via cAMP signaling. Nutraceuticals that quell an increase in beta cell ROS production, that amplify or mimic autocrine insulin signaling, or that boost GLP-1 production, should help to maintain GSIS and suppress beta cell apoptosis in the face of glucolipotoxicity, postponing or preventing onset of type 2 diabetes. Nutraceuticals with potential in this regard include the following: phycocyanobilin-an inhibitor of NOX2; agents promoting mitophagy and mitochondrial biogenesis, such as ferulic acid, lipoic acid, melatonin, berberine, and astaxanthin; myo-inositol and high-dose biotin, which promote phosphatidylinositol 3-kinase (PI3K)/Akt activation; and prebiotics/probiotics capable of boosting GLP-1 secretion. Complex supplements or functional foods providing a selection of these agents might be useful for diabetes prevention.
C1 [McCarty, Mark F.] Catalyt Longev Fdn, San Diego, CA 92109 USA.
   [DiNicolantonio, James J.] St Lukes Mid Amer Heart Inst, Dept Prevent Cardiol, Kansas City, MO 64111 USA.
C3 Saint Luke's Mid America Heart Institute
RP McCarty, MF (corresponding author), Catalyt Longev Fdn, San Diego, CA 92109 USA.; DiNicolantonio, JJ (corresponding author), St Lukes Mid Amer Heart Inst, Dept Prevent Cardiol, Kansas City, MO 64111 USA.
EM markfmccarty@gmail.com; jjdinicol@gmail.com
OI DiNicolantonio, James/0000-0002-7888-1528
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NR 149
TC 1
Z9 2
U1 0
U2 17
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2227-9032
J9 HEALTHCARE-BASEL
JI Healthcare
PD JAN
PY 2022
VL 10
IS 1
AR 3
DI 10.3390/healthcare10010003
PG 13
WC Health Care Sciences & Services; Health Policy & Services
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services
GA YM0LE
UT WOS:000746274100001
PM 35052168
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Olaniyi, KS
   Olatunji, LA
AF Olaniyi, Kehinde Samuel
   Olatunji, Lawrence Aderemi
TI Glutamine confers renoprotection by normalizing lipid and glutathione
   content in insulin-resistant pregnant rats
SO CHEMICO-BIOLOGICAL INTERACTIONS
LA English
DT Article
DE High fructose; Glutamine; Glutathione; Lipid accumulation; Metabolic
   syndrome; Renal injury
ID CHRONIC KIDNEY-DISEASE; BODY-MASS INDEX; REDOX STATUS; URIC-ACID; RISK;
   INFLAMMATION; FRUCTOSE; OBESITY; STRESS
AB Objective: Increasing consumption of fructose is a major contributor to epidemic metabolic syndrome (MS), and the risk of renal disorders and/or injuries remains high among individuals with MS particularly during pregnancy. Glutamine (GLT) has been demonstrated to have a modulatory effect in MS and/or insulin resistance (IR). This study investigated the effect of GLT on renal lipid accumulation and glutathione depletion induced by high fructose-enriched drink (FED) in pregnant rats and also tested the hypothesis that the renoprotective role of GLT is by suppression of adenosine deaminase (ADA)/xanthine oxidase (XO)/uric acid (UA) pathway.
   Methods: Pregnant Wistar rats weighing between 160 and 180 g were allotted into Control, GLT, FED and FED + GLT groups (6 rats/group). The groups received distilled water (vehicle, p. o.), 1 g/kg bw GLT (p.o.), 10% Fructose (w/v) and 10% Fructose (w/v) plus 1 g/kg bw GLT (p.o.) respectively, daily for 19 days.
   Results: Data showed that FED caused IR, increased body weight gain, blood glucose, plasma insulin, creatinine, urea, lipid accumulation, lipid peroxidation, lactate production, aspartate transaminase and alanine aminotransferase, depressed Glucose-6-phosphate dehydrogenase, sodium-potassium-ATPase activities and glutathione. These alterations were accompanied by increased activity of ADA/XO/UA pathway. However, the FED-induced renal injury and its correlates were normalized by GLT supplementation.
   Conclusion: The present results demonstrate that renal lipid accumulation and glutathione depletion-driven renal injury in pregnant rats is accompanied by increased activity of ADA/XO/UA pathway. The findings also suggest that GLT would confer protection against renal injury by protecting against lipid accumulation and glutathionedepletion, at least in part, through suppression of ADA/XO/UA pathway.
C1 [Olaniyi, Kehinde Samuel; Olatunji, Lawrence Aderemi] Univ Ilorin, Coll Hlth Sci, Hope Cardiometab Res Team, PMB 1515, Ilorin, Nigeria.
   [Olaniyi, Kehinde Samuel; Olatunji, Lawrence Aderemi] Univ Ilorin, Coll Hlth Sci, Dept Physiol, PMB 1515, Ilorin 240001, Nigeria.
   [Olaniyi, Kehinde Samuel] Afe Babalola Univ, Coll Med & Hlth Sci, Dept Physiol, Ado Ekiti, Nigeria.
C3 University of Ilorin; University of Ilorin
RP Olatunji, LA (corresponding author), Univ Ilorin, Coll Hlth Sci, Dept Physiol, PMB 1515, Ilorin 240001, Nigeria.
EM tunjilaw@unilorin.edu.ng
RI Olaniyi, Kehinde/GPK-5850-2022
OI Olaniyi, Kehinde/0000-0002-8229-9688; Olatunji, Lawrence
   Aderemi/0000-0002-1036-0662
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NR 51
TC 6
Z9 7
U1 0
U2 6
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0009-2797
EI 1872-7786
J9 CHEM-BIOL INTERACT
JI Chem.-Biol. Interact.
PD SEP 1
PY 2019
VL 310
AR 108721
DI 10.1016/j.cbi.2019.06.034
PG 8
WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology
GA IS5GD
UT WOS:000482179600008
PM 31233715
DA 2025-06-11
ER

PT J
AU Bhatta, A
   Yao, L
   Xu, ZM
   Toque, HA
   Chen, JJ
   Atawia, RT
   Fouda, AY
   Bagi, Z
   Lucas, R
   Caldwell, RB
   Caldwell, RW
AF Bhatta, Anil
   Yao, Lin
   Xu, Zhimin
   Toque, Haroldo A.
   Chen, Jijun
   Atawia, Reem T.
   Fouda, Abdelrahman Y.
   Bagi, Zsolt
   Lucas, Rudolf
   Caldwell, Ruth B.
   Caldwell, Robert W.
TI Obesity-induced vascular dysfunction and arterial stiffening requires
   endothelial cell arginase 1
SO CARDIOVASCULAR RESEARCH
LA English
DT Article
DE Obesity; Vascular dysfunction; Arginase; Fibrosis; Diabetes
ID NITRIC-OXIDE SYNTHASE; ARGININE BIOAVAILABILITY; CARDIOVASCULAR-DISEASE;
   AORTIC STIFFNESS; INHIBITION; INFLAMMATION; CONTRIBUTES; ROLES; FAT;
   HYPERTENSION
AB Aims Elevation of arginase activity has been linked to vascular dysfunction in diabetes and hypertension by a mechanism involving decreased nitric oxide (NO) bioavailability due to L-arginine depletion. Excessive arginase activity also can drive L-arginine metabolism towards the production of ornithine, polyamines, and proline, promoting proliferation of vascular smooth muscle cells and collagen formation, leading to perivascular fibrosis. We hypothesized that there is a specific involvement of arginase 1 expression within the vascular endothelial cells in this pathology.
   Methods and results To test this proposition, we used models of type 2 diabetes and metabolic syndrome. Studies were performed using wild type (WT), endothelial-specific arginase 1 knockout (EC-A1(-/-)) and littermate controls(A1(con)) mice fed high fat-high sucrose (HFHS) or normal diet (ND) for 6 months and isolated vessels exposed to palmitate-high glucose (PA/HG) media. Some WT mice or isolated vessels were treated with an arginase inhibitor, ABH [2-(S)amino- 6-boronohexanoic acid. In WT mice, the HFHS diet promoted increases in body weight, fasting blood glucose, and post-prandial insulin levels along with arterial stiffening and fibrosis, elevated blood pressure, decreased plasma levels of L-arginine, and elevated L-ornithine. The HFHS diet or PA/HG treatment also induced increases in vascular arginase activity along with oxidative stress, reduced vascular NO levels, and impaired endothelial-dependent vasorelaxation. All of these effects except obesity and hypercholesterolemia were prevented or significantly reduced by endothelial-specific deletion of arginase 1 or ABH treatment.
   Conclusion Vascular dysfunctions in diet-induced obesity are prevented by deletion of arginase 1 in vascular endothelial cells or arginase inhibition. These findings indicate that upregulation of arginase 1 expression/activity in vascular endothelial cells has an integral role in diet-induced cardiovascular dysfunction and metabolic syndrome.
C1 [Bhatta, Anil; Yao, Lin; Toque, Haroldo A.; Chen, Jijun; Atawia, Reem T.; Fouda, Abdelrahman Y.; Lucas, Rudolf; Caldwell, Robert W.] Augusta Univ, Med Coll Georgia, Dept Pharmacol & Toxicol, Augusta, GA 30912 USA.
   [Xu, Zhimin; Fouda, Abdelrahman Y.; Bagi, Zsolt; Lucas, Rudolf; Caldwell, Ruth B.; Caldwell, Robert W.] Augusta Univ, Med Coll Georgia, Vasc Biol Ctr, Augusta, GA 30912 USA.
   [Bagi, Zsolt] Augusta Univ, Med Coll Georgia, Dept Med, Augusta, GA 30912 USA.
   [Caldwell, Ruth B.] Augusta Univ, Med Coll Georgia, Dept Cell Biol & Anat, Augusta, GA 30912 USA.
   [Caldwell, Ruth B.] Vet Adm Med Ctr, Augusta, GA 30912 USA.
   [Bhatta, Anil] Johns Hopkins Univ, Sch Med, Dept Anaesthesiol & Emergency Med, Baltimore, MD 21205 USA.
   [Yao, Lin] Guangzhou Univ Chinese Med, Sch Pharmaceut Sci, South China Res Ctr Acupuncture & Moxibust, Guangzhou 510006, Guangdong, Peoples R China.
C3 University System of Georgia; Augusta University; University System of
   Georgia; Augusta University; University System of Georgia; Augusta
   University; University System of Georgia; Augusta University; US
   Department of Veterans Affairs; Veterans Health Administration (VHA);
   Johns Hopkins University; Guangzhou University of Chinese Medicine
RP Caldwell, RW (corresponding author), Augusta Univ, Med Coll Georgia, Dept Pharmacol & Toxicol, Augusta, GA 30912 USA.; Caldwell, RW (corresponding author), Augusta Univ, Med Coll Georgia, Vasc Biol Ctr, Augusta, GA 30912 USA.
EM wcaldwel@augusta.edu
RI Lucas, Rudolf/ABA-3011-2020; Caldwell, Robert/LOR-8617-2024; Fouda,
   Abdel/GYI-9576-2022; Atawia, Reem/AIA-3014-2022
OI Caldwell, Ruth/0000-0003-0168-0354; Atawia, Reem/0000-0003-1360-4228;
   FOUDA, ABDELRAHMAN/0000-0003-3042-9425; Bagi, Zsolt/0000-0001-8755-2980;
   Lucas, Rudolf/0000-0003-3805-8868
FU National Institute of Health [R01 HL070215, R01 EY01176, R24 DK-94765];
   American Diabetes Association [1-16-IBS-196]; Veterans Administration
   [I01BX003221]; National Science Foundation for Distinguished Young
   Scholars of China [31600937]
FX Funding was provided by the National Institute of Health grants: R01
   HL070215 (R.W.C.), R01 EY01176 (R.B.C. and R.W.C., and R24 DK-94765
   (R.W.C., R.B.C., and R.L.). The work was also supported by the American
   Diabetes Association grant 1-16-IBS-196 (RL), Veterans Administration
   Merit Review Award I01BX003221 (RBC) and National Science Foundation for
   Distinguished Young Scholars of China: 31600937 (LY)
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NR 75
TC 83
Z9 85
U1 2
U2 19
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0008-6363
EI 1755-3245
J9 CARDIOVASC RES
JI Cardiovasc. Res.
PD NOV
PY 2017
VL 113
IS 13
BP 1664
EP 1676
DI 10.1093/cvr/cvx164
PG 13
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA FK4IK
UT WOS:000413456100018
PM 29048462
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Machado, RM
   Stetano, JT
   Oliveira, CPMS
   Mello, ES
   Ferreira, FD
   Nunes, VS
   de Lima, VMR
   Quintao, ECR
   Catanozi, S
   Nakandakare, ER
   Lottenberg, AMP
AF Machado, Roberta M.
   Stetano, Jose T.
   Oliveira, Claudia P. M. S.
   Mello, Evandro S.
   Ferreira, Fabiana D.
   Nunes, Valeria S.
   de Lima, Vicencia M. R.
   Quintao, Eder C. R.
   Catanozi, Sergio
   Nakandakare, Edna R.
   Lottenberg, Ana Maria P.
TI Intake of trans Fatty Acids Causes Nonalcoholic Steatohepatitis
   and Reduces Adipose Tissue Fat Content
SO JOURNAL OF NUTRITION
LA English
DT Article
ID CONJUGATED LINOLEIC-ACID; LIVER-DISEASE; INSULIN-RESISTANCE; METABOLIC
   SYNDROME; MITOCHONDRIAL DYSFUNCTION; CARDIOVASCULAR-DISEASE;
   ENERGY-EXPENDITURE; OXIDATIVE STRESS; CHOLESTEROL; MOUSE
AB We investigated the effects of dietary trans fatty acids, PUFA, and SEA on body and liver fat content, liver histology, and mRNA of enzymes involved in fatty acid metabolism. LDL receptor knockout weaning male mice were fed for 16 wk with diets containing 40% energy as either trans fatty acids (TRANS), PUFA, or SEA. Afterwards, subcutaneous and epididymal fat were weighed and histological markers of nonalcoholic fatty liver disease (NAFLD) were assessed according to the Histological Scoring System for NAFLD. PPAR alpha, PPAR gamma, microsomal triglyceride transfer protein (MTP), carnitine palmitoyl transferase 1 (CPT-1), and sterol regulatory element binding protein-1c (SREBP-1c) mRNA were measured by quantitative RT-PCR. Food intake was similar in the 3 groups, although mice fed the TRANS diet gained less weight than those receiving the PUFA diet. Compared with the PUFA- and SEA-fed mice, TRANS-fed mice had greater plasma total cholesterol (TC) and triglyceride (TG) concentrations, less epididymal and subcutaneous fat, larger livers with nonalcoholic steatohepatitis (NASH)-like lesions, and greater liver TC and TG concentrations. Macrosteatosis in TRANS-fed mice was associated with a higher homeostasis model assessment of insulin resistance (HOMA(IR)) index and upregulated mRNA related to hepatic fatty acid synthesis (SREBP-1 c and PPAR gamma) and to downregulated MTP mRNA. Diet consumption did not alter hepatic mRNA related to fatty acid oxidation (PPAR alpha and CPT-1). In conclusion, compared with PUFA- and SFA-fed mice, TRANS-fed mice had less adiposity, impaired glucose tolerance characterized by greater HOMA(IR) index, and NASH-like lesions due to greater hepatic lipogenesis. These results demonstrate the role of trans fatty acid intake on the development of key features of metabolic syndrome. J. Nutr. 140: 1127-1132, 2010.
C1 [Machado, Roberta M.; Ferreira, Fabiana D.; Nunes, Valeria S.; Quintao, Eder C. R.; Catanozi, Sergio; Nakandakare, Edna R.; Lottenberg, Ana Maria P.] Univ Sao Paulo, Fac Med Sci Univ, Endocrinol & Metab Div, Lipids Lab,LIM 10, BR-01246903 Sao Paulo, Brazil.
   [Mello, Evandro S.] Univ Sao Paulo, Fac Med Sci, Dept Pathol, LIM 14, BR-01246903 Sao Paulo, Brazil.
   [Stetano, Jose T.; Oliveira, Claudia P. M. S.; de Lima, Vicencia M. R.] Univ Sao Paulo, Dept Gastroenterol, LIM 07, BR-01246903 Sao Paulo, Brazil.
C3 Universidade de Sao Paulo; Universidade de Sao Paulo; Universidade de
   Sao Paulo
RP Lottenberg, AMP (corresponding author), Univ Sao Paulo, Fac Med Sci Univ, Endocrinol & Metab Div, Lipids Lab,LIM 10, BR-01246903 Sao Paulo, Brazil.
EM amlottenberg@uol.com.br
RI Lottenberg, Ana/N-2531-2017; Catanozi, Sergio/D-6634-2012; Oliveira,
   Claudia/D-1216-2014; Stefano, Jose/H-4792-2013; Mello,
   Evandro/AHD-4795-2022; Quintão, Eder/H-9180-2013; Nakandakare,
   Edna/D-6625-2012; Sutti Nunes, Valeria/G-4778-2012
OI P Oliveira, Claudia/0000-0002-2848-417X; Catanozi,
   Sergio/0000-0002-2997-1260; Machado, Roberta
   Marcondes/0000-0003-0566-6410; Quintao, Eder/0000-0001-9810-3259; Sutti
   Nunes, Valeria/0000-0002-6769-5412
FU State of Sao Paulo Research Foundation (FAPESP) [06/55516-8]
FX Supported by the State of Sao Paulo Research Foundation (FAPESP no.
   06/55516-8). Fats were provided by UNILEVER Best Foods (SP, Brazil) and
   gas-liquid chromatographic analyses was conducted by Cognis Brasil LTDA.
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NR 39
TC 66
Z9 72
U1 2
U2 14
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0022-3166
EI 1541-6100
J9 J NUTR
JI J. Nutr.
PD JUN
PY 2010
VL 140
IS 6
BP 1127
EP 1132
DI 10.3945/jn.109.117937
PG 6
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 597ZH
UT WOS:000277800700011
PM 20357081
OA Bronze
DA 2025-06-11
ER

PT J
AU McMillen, IC
   MacLaughlin, SM
   Muhlhausler, BS
   Gentili, S
   Duffield, JL
   Morrison, JL
AF McMillen, I. Caroline
   MacLaughlin, Severence M.
   Muhlhausler, Beverly S.
   Gentili, Sheridan
   Duffield, Jaime L.
   Morrison, Janna L.
TI Developmental origins of adult health and disease: The role of
   periconceptional and foetal nutrition
SO BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
LA English
DT Article; Proceedings Paper
CT International Conference on Foetal Programming and Development Toxicity
CY MAY 20-24, 2007
CL Torshavn, DENMARK
ID PITUITARY-ADRENAL AXIS; METABOLIC SYNDROME; ANGIOTENSIN-II; SHEEP FETUS;
   MATERNAL UNDERNUTRITION; PLACENTAL RESTRICTION; BLOOD-PRESSURE;
   BIRTH-WEIGHT; GROWTH; ALTERS
AB The 'developmental origins of adult health and disease' hypothesis stated that environmental factors, particularly maternal undernutrition, act in early life to programme the risks for adverse health outcomes, such as cardiovascular disease, obesity and the metabolic syndrome in adult life. Early physiological tradeoffs, including activation of the foetal hypothalamo-pituitary-adrenal (HPA) axis, confer an early fitness advantage such as foetal survival, while incurring delayed health costs. We review the evidence that such tradeoffs are anticipated from conception and that the periconceptional nutritional environment can programme the developmental trajectory of the stress axis and the systems that maintain and regulate arterial blood pressure. There is also evidence that restriction of placental growth and function, results in an increased dependence of the maintenance of arterial blood pressure on the sequential recruitment of the sympathetic nervous system and HPA axis. While the 'early origins of adult disease' hypothesis has focussed on the impact of maternal undernutrition, an increase in maternal nutritional intake and in maternal body mass intake has become more prevalent in developed countries. Exposure to overnutrition in foetal life results in a series of central and peripheral neuroendocrine responses that in turn programme development of the fat cell and of the central appetite regulatory system. While the physiological responses to foetal undernutrition result in the physiological trade off between foetal survival and poor health outcomes that emerge after reproductive senescence, exposure to early overnutrition results in poor health outcomes that emerge in childhood and adolescence. Thus, the effects of early overnutrition can directly impact on reproductive fitness and on the health of the next generation. In this context, the physiological responses to relative overnutrition in early life may directly contribute to an intergenerational cycle of obesity.
C1 [McMillen, I. Caroline; MacLaughlin, Severence M.; Muhlhausler, Beverly S.; Gentili, Sheridan; Duffield, Jaime L.; Morrison, Janna L.] Univ S Australia, Sansom Inst, Sch Pharm & Med Sci, Early Origins Adult Hlth Res Grp, Adelaide, SA 5000, Australia.
C3 University of South Australia
RP McMillen, IC (corresponding author), Univ S Australia, Sansom Inst, Sch Pharm & Med Sci, Early Origins Adult Hlth Res Grp, Adelaide, SA 5000, Australia.
EM caroline.mcmillen@unisa.edu.au
RI McMillen, Isabella/N-5540-2019; Gentili, Sheridan/A-1987-2011; Duffield,
   Jaime A./MIU-1920-2025; Morrison, Janna/B-8308-2009
OI Duffield, Jaime A./0000-0003-4411-1733; Morrison,
   Janna/0000-0002-8602-8519; Gentili, Sheridan/0000-0001-5568-9106;
   Muhlhausler, Beverly/0000-0002-9021-6790
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NR 47
TC 191
Z9 210
U1 0
U2 43
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-7835
EI 1742-7843
J9 BASIC CLIN PHARMACOL
JI Basic Clin. Pharmacol. Toxicol.
PD FEB
PY 2008
VL 102
IS 2
BP 82
EP 89
DI 10.1111/j.1742-7843.2007.00188.x
PG 8
WC Pharmacology & Pharmacy; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Pharmacology & Pharmacy; Toxicology
GA 254LU
UT WOS:000252588900004
PM 18226059
OA Bronze
DA 2025-06-11
ER

PT J
AU Montgomery, CL
   Johnson, HM
   Johnston, TP
   Koulen, P
AF Montgomery, Christa L.
   Johnson, Heather M.
   Johnston, Thomas P.
   Koulen, Peter
TI Mechanisms Underlying Early-Stage Changes in Visual Performance and
   Retina Function After Experimental Induction of Sustained Dyslipidemia
SO NEUROCHEMICAL RESEARCH
LA English
DT Article
DE Metabolic syndrome; Mouse; Oxidative stress; Plasma lipid; Poloxamer
   407; Visual impairment
ID LIPID-PEROXIDATION; LIPEMIA-RETINALIS; MICE; CELL; POLOXAMER-407;
   DYSFUNCTION; APOPTOSIS; OXIDATION; FEATURES; LESIONS
AB Visual and retinal function was measured in a mouse model of chemically induced, sustained dyslipidemia to determine the contribution of dyslipidemia to the pathogenesis of retinopathy in the context of metabolic syndrome. Fifteen male C57BL/6Crl mice were divided into three groups. Poloxamer 407 (P-407), 14.5% w/w was delivered at a rate of 6 A mu l/day by implanted osmotic mini-pumps either subcutaneously (P-407 SQ) or intraperitoneally (P-407 IP) to P-407-treated mice, whereas saline was administered at the same rate to control mice using only the subcutaneous route of administration. Total cholesterol (TC) and true triglyceride (TG) levels were quantified from plasma. Optomotor responses to stimuli of varying spatial frequency or contrast were used to measure visual acuity and contrast sensitivity. Retinal function was determined using Ganzfeld flash electroretinography (ERG). At 32 days, TC for the P-407 IP group was significantly elevated compared to saline controls (169.4 +/- 16.5 mg/dl, 0.001 < P < 0.01). TG levels for both the P-407 SQ (59.3 +/- 22.4 mg/dl, 0.01 < P < 0.05) and P-407 IP groups (67.7 +/- 18.0 mg/dl, 0.001 < P < 0.01) were significantly elevated relative to controls. Electroretinography demonstrated a very significant decline in the b/a ratio (1.80 +/- 0.11, P < 0.01) for the P-407 IP group. The b/a ratio exhibited a moderate, significant correlation with TC levels (r = - 0.4425, P = 0.0392) and a strong, very significant correlation with TG levels (r = - 0.6190, P = 0.0021). Delivery of P-407 via osmotic mini-pump resulted in the sustained, significant elevation of plasma TC and TG levels. This elevation in plasma lipid levels was correlated with a decline in inner retinal function.
C1 [Montgomery, Christa L.; Johnson, Heather M.; Johnston, Thomas P.; Koulen, Peter] Univ Missouri, Sch Med, Vis Res Ctr, Dept Ophthalmol, Kansas City, MO 64108 USA.
   [Johnston, Thomas P.] Univ Missouri, Sch Pharm, Div Pharmaceut Sci, Kansas City, MO 64108 USA.
   [Koulen, Peter] Univ Missouri, Sch Med, Dept Biomed Sci, Kansas City, MO 64108 USA.
C3 University of Missouri System; University of Missouri Kansas City;
   University of Missouri System; University of Missouri Kansas City;
   University of Missouri System; University of Missouri Kansas City
RP Koulen, P (corresponding author), Univ Missouri, Sch Med, Vis Res Ctr, Dept Ophthalmol, Kansas City, MO 64108 USA.; Koulen, P (corresponding author), Univ Missouri, Sch Med, Dept Biomed Sci, Kansas City, MO 64108 USA.
EM koulenp@umkc.edu
OI Montgomery, Christa/0009-0004-2430-2772
FU NIH from NIH/NIA [AG027956]; NIH from NIH/NCRR [RR027093]; NIH from
   NIH/NEI [EY022774, EY027005]; Felix and Carmen Sabates Missouri Endowed
   Chair in Vision Research; Vision Research Foundation of Kansas City;
   Research to Prevent Blindness
FX The research presented in the present publication was supported in part
   by NIH grants AG027956 from NIH/NIA, RR027093 from NIH/NCRR, EY022774
   and EY027005 from NIH/NEI (PK). The content is solely the responsibility
   of the authors and does not necessarily represent the official views of
   the National Institutes of Health. Additional support by the Felix and
   Carmen Sabates Missouri Endowed Chair in Vision Research, the Vision
   Research Foundation of Kansas City (PK) and a departmental challenge
   grant by Research to Prevent Blindness (PK, TPJ) is gratefully
   acknowledged. The authors thank Margaret, Richard and Sara Koulen for
   generous support and encouragement.
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NR 48
TC 9
Z9 9
U1 0
U2 2
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0364-3190
EI 1573-6903
J9 NEUROCHEM RES
JI Neurochem. Res.
PD AUG
PY 2018
VL 43
IS 8
BP 1500
EP 1510
DI 10.1007/s11064-018-2563-2
PG 11
WC Biochemistry & Molecular Biology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Neurosciences & Neurology
GA GM9GO
UT WOS:000438554800002
PM 29860619
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Yang, PS
   Kim, TH
   Uhm, JS
   Park, S
   Joung, B
   Lee, MH
   Pak, HN
AF Yang, Pil-Sung
   Kim, Tae-hoon
   Uhm, Jae-Sun
   Park, Sungha
   Joung, Boyoung
   Lee, Moon-Hyoung
   Pak, Hui-Nam
TI High plasma level of soluble RAGE is independently associated with a low
   recurrence of atrial fibrillation after catheter ablation in diabetic
   patient
SO EUROPACE
LA English
DT Article
DE Soluble RAGE; Atrial fibrillation; Recurrence; Catheter ablation;
   Diabetes mellitus; Inflammation; Oxidative stress
ID GLYCATION END-PRODUCTS; METABOLIC SYNDROME; SERUM-LEVELS; RECEPTOR;
   DISEASE; SRAGE; ATHEROSCLEROSIS; PREDICTOR; HEART; RISK
AB Atrial fibrillation (AF) is closely associated with metabolic syndrome, and the receptor for advanced glycation end products (RAGE) pathway is involved in insulin resistance and cardiac remodelling. We hypothesized that plasma level of soluble RAGE (sRAGE) would predict clinical outcome after radiofrequency catheter ablation for AF.
   We measured pre-procedural plasma level of sRAGE in 496 patients who underwent AF ablation (142 patients with diabetes, 354 patients without diabetes selected by matching them with diabetic patients according to age, sex, and AF type). (i) Plasma level of sRAGE was significantly higher in diabetic patients than in non-diabetics (580.0 +/- 576.4 vs. 435.8 +/- 280.7 pg/mL, P = 0.005), but there was no difference in sRAGE levels between patients with clinical recurrence of AF and those without. (ii) During 24.5 +/- 18.0 months of follow-up, the recurrence of AF was significantly lower in the diabetic patient group with high sRAGE (a parts per thousand yen418 pg/mL based on the median value) than the diabetic patient group with low sRAGE (log-rank P = 0.045). This was especially pronounced in patients with paroxysmal AF and diabetes (log-rank P = 0.016), but no association was found in non-diabetics. (iii) In multivariate Cox regression analysis, high sRAGE (HR 0.395, 95% CI 0.175-0.894, P = 0.026) and paroxysmal AF (HR 0.387, 95% CI 0.179-0.835, P = 0.016) were independently associated with the favourable clinical outcome of rhythm control after AF ablation in diabetic patients.
   High plasma level of sRAGE was independently associated with low AF recurrence after catheter ablation in diabetic patients, especially those with paroxysmal AF.
C1 [Yang, Pil-Sung; Kim, Tae-hoon; Uhm, Jae-Sun; Park, Sungha; Joung, Boyoung; Lee, Moon-Hyoung; Pak, Hui-Nam] Yonsei Univ Hlth Syst, 50 Yonsei Ro, Seoul 120752, South Korea.
C3 Yonsei University; Yonsei University Health System
RP Pak, HN (corresponding author), Yonsei Univ Hlth Syst, 50 Yonsei Ro, Seoul 120752, South Korea.
EM hnpak@yuhs.ac
RI CHIA, YOOK CHIN/B-8379-2010; LEE, HYUN/ABC-6119-2021; Kim,
   Tae-Hoon/AAG-3292-2021; Pak, Hui-Nam/C-4266-2015
OI Joung, Boyoung/0000-0001-9036-7225; Lee,
   Moon-Hyoung/0000-0002-7268-0741; Yang, Pil-sung/0000-0002-6552-1742;
   Pak, Hui-Nam/0000-0002-3256-3620; Kim, Tae-Hoon/0000-0003-4200-3456;
   Uhm, Jae-Sun/0000-0002-1611-8172
FU Korea Health 21 R&D Project, Ministry of Health and Welfare [A085136];
   National Research Foundation of Korea (NRF) - Ministry of Science, ICT &
   Future Planning (MSIP) [7-2013-0362]
FX This work was supported by a grant (A085136) from the Korea Health 21
   R&D Project, Ministry of Health and Welfare, and a grant (7-2013-0362)
   from the National Research Foundation of Korea (NRF) funded by the
   Ministry of Science, ICT & Future Planning (MSIP).
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NR 21
TC 14
Z9 15
U1 0
U2 4
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1099-5129
EI 1532-2092
J9 EUROPACE
JI Europace
PD NOV
PY 2016
VL 18
IS 11
BP 1711
EP 1718
DI 10.1093/europace/euv449
PG 8
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA ED0VA
UT WOS:000388559200007
PM 26838688
OA Bronze
DA 2025-06-11
ER

PT J
AU Okatan, EN
   Tuncay, E
   Hafez, G
   Turan, B
AF Okatan, Esma N.
   Tuncay, Erkan
   Hafez, Gaye
   Turan, Belma
TI Profiling of cardiac β-adrenoceptor subtypes in the cardiac left
   ventricle of rats with metabolic syndrome: Comparison with
   streptozotocin-induced diabetic rats
SO CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
LA English
DT Article
DE sympathetic stimulation; high-sucrose diet; type 1 diabetes; cardiac
   dysfunction; intracellular calcium homeostasis
ID INTRACELLULAR CA2+; OXIDATIVE STRESS; WEIGHT-GAIN; SHORT-TERM;
   STIMULATION; ALTERNANS; SELENIUM; HEART; BETA(3)-ADRENOCEPTORS;
   CARDIOMYOPATHY
AB Little is known about metabolic syndrome (MetS)-associated cardiomyopathy, especially in relation to the role and contribution of beta-adrenoceptor (beta-AR) subtypes. Therefore, we examined the roles of beta-AR subtypes in the cardiac function of rats with MetS (MetS group) and compared it with that of rats with streptozotocin (STZ)-induced diabetes (STZ group). Compared with the normal control rats, the protein levels of cardiac beta(1)-and beta(2)-AR in the MetS group were significantly decreased and with no changes in their mRNA levels, whereas the protein levels of beta(3)-AR were similar to those of the controls. However, as shown previously, the protein levels of cardiac beta(1)-and beta(2)-AR in the STZ group were decreased, whereas the beta(3)-AR levels were significantly increased by comparison with the controls. Additionally, the mRNA levels of beta(2)-and beta(3)-AR were increased, but beta(1)-AR mRNA was decreased in the STZ group. Furthermore, left ventricular developed pressure responses to beta(3)-AR agonist BRL37344 were increased in the STZ group but not in the MetS group, whereas for both groups, the responses to noradrenaline were not different from those of the controls. However, the response to stimulation with high concentrations of fenoterol was depressed in the MetS group, compared with the controls, but not in the STZ group. Consequently, our data suggest that the contribution of the beta-AR system to cardiac dysfunction in the rats with MetS is not the same as that in the STZ group, although they have similar cardiac dysfunction with similar ultrastructural changes to the myocardium.
C1 [Okatan, Esma N.; Tuncay, Erkan; Hafez, Gaye; Turan, Belma] Ankara Univ, Fac Med, Dept Biophys, TR-06100 Ankara, Turkey.
C3 Ankara University
RP Turan, B (corresponding author), Ankara Univ, Fac Med, Dept Biophys, TR-06100 Ankara, Turkey.
EM belma.turan@medicine.ankara.edu.tr
RI Okatan, Esma/A-7202-2016; HAFEZ, GAYE/G-6482-2016; TURAN,
   Belma/AAG-8084-2020; TUNCAY, ERKAN/AAG-8065-2020; Okatan, Esma
   Nur/LNP-9142-2024
OI TUNCAY, ERKAN/0000-0002-6675-2534; TURAN, Belma/0000-0003-2583-9294;
   Okatan, Esma Nur/0000-0002-0795-6078
FU TUBITAK [SBAG-113S466]
FX This study was supported by TUBITAK SBAG-113S466. Authors thank to S.
   Kizil for her histological examinations. Conflict of interest: The
   authors declare that there is no potential conflict of interest
   associated with this study.
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NR 61
TC 18
Z9 19
U1 0
U2 20
PU CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS
PI OTTAWA
PA 65 AURIGA DR, SUITE 203, OTTAWA, ON K2E 7W6, CANADA
SN 0008-4212
EI 1205-7541
J9 CAN J PHYSIOL PHARM
JI Can. J. Physiol. Pharmacol.
PD JUL
PY 2015
VL 93
IS 7
BP 517
EP 525
DI 10.1139/cjpp-2014-0507
PN 1
PG 9
WC Pharmacology & Pharmacy; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Physiology
GA CL9CQ
UT WOS:000357272900004
PM 25994289
DA 2025-06-11
ER

PT J
AU Ros, E
   Martínez-González, MA
   Estruch, R
   Salas-Salvadó, J
   Fitó, M
   Martínez, JA
   Corella, D
AF Ros, Emilio
   Martinez-Gonzalez, Miguel A.
   Estruch, Ramon
   Salas-Salvado, Jordi
   Fito, Montserrat
   Martinez, Jose A.
   Corella, Dolores
TI Mediterranean Diet and Cardiovascular Health: Teachings of the PREDIMED
   Study
SO ADVANCES IN NUTRITION
LA English
DT Article
ID INTIMA-MEDIA THICKNESS; METABOLIC SYNDROME; RISK-FACTORS;
   MYOCARDIAL-INFARCTION; STYLE DIET; DISEASE; PATTERN; ASSOCIATION;
   PREVENTION; MORTALITY
AB The PREDIMED (Prevencion con Dieta Mediterranea) study was designed to assess the long-term effects of the Mediterranean diet (MeDiet) without any energy restriction on incident cardiovascular disease (CVD) as a multicenter, randomized, primary prevention trial in individuals at high risk. Participants were randomly assigned to 3 diet groups: 1) MeDiet supplemented with extra-virgin olive oil (EVOO); 2) MeDiet supplemented with nuts; and 3) control diet (advice on a low-fat diet). After 4.8 y, 288 major CVD events occurred in 7447 participants; crude hazard ratios were 0.70 (95% CI: 0.53, 0.91) for the MeDiet + EVOO and 0.70 (95% CI: 0.53, 0.94) for the MeDiet + nuts compared with the control group. Respective hazard ratios for incident diabetes (273 cases) among 3541 participants without diabetes were 0.60 (95% CI: 0.43, 0.85) and 0.82 (95% CI: 0.61, 1.10) compared with the control group. After 1-y follow-up, participants in the MeDiet + nuts group showed a significant 13.7% reduction in prevalence of metabolic syndrome compared with reductions of 6.7% and 2.0% in the MeDiet + EVOO and control groups, respectively. Analyses of intermediate markers of cardiovascular risk demonstrated beneficial effects of the MeDiets on blood pressure, lipid profiles, lipoprotein particles, inflammation, oxidative stress, and carotid atherosclerosis, as well as on the expression of proatherogenic genes involved in vascular events and thrombosis. Nutritional genomics studies demonstrated interactions between a MeDiet and cyclooxygenase-2 (COX-2), interleukin-6 (IL-6), apolipoprotein A2 (APOA2), cholesteryl ester transfer protein plasma (CUP), and transcription factor 7-like 2 (TCF7L2) gene polymorphisms. The PREDIMED study results demonstrate that a high-unsaturated fat and antioxidant-rich dietary pattern such as the MeDiet is a useful tool in the prevention of CVD.
C1 [Ros, Emilio] Univ Barcelona, Hosp Clin, Endocrinol & Nutr Serv, Lipid Clin, Barcelona, Spain.
   [Estruch, Ramon] Univ Barcelona, Hosp Clin, Inst Invest Biomed August Pi Sunyer IDIBAPS, Dept Internal Med, Barcelona, Spain.
   [Martinez-Gonzalez, Miguel A.] Univ Navarra, Dept Prevent Med, E-31080 Pamplona, Spain.
   [Martinez-Gonzalez, Miguel A.] Univ Navarra, Dept Publ Hlth, E-31080 Pamplona, Spain.
   [Martinez, Jose A.] Univ Navarra, Dept Nutr & Food Sci, E-31080 Pamplona, Spain.
   [Martinez, Jose A.] Univ Navarra, Dept Physiol, E-31080 Pamplona, Spain.
   [Martinez, Jose A.] Univ Navarra, Dept Toxicol, E-31080 Pamplona, Spain.
   [Salas-Salvado, Jordi] Univ Rovira & Virgili, Pere Virgili Hlth Res Inst, St Joan Univ Hosp, Human Nutr Dept, E-43201 Reus, Spain.
   [Fito, Montserrat] Hosp del Mar, Res Inst, Cardiovasc & Nutr Res Grp, Barcelona, Spain.
   [Fito, Montserrat] Hosp del Mar, Res Inst, Regicor Study Grp, Barcelona, Spain.
   [Corella, Dolores] Univ Valencia, Dept Prevent Med, Valencia, Spain.
C3 University of Barcelona; Hospital Clinic de Barcelona; University of
   Barcelona; Hospital Clinic de Barcelona; IDIBAPS; University of Navarra;
   University of Navarra; University of Navarra; University of Navarra;
   University of Navarra; Universitat Rovira i Virgili; Hospital del Mar
   Research Institute; Hospital del Mar; Hospital del Mar Research
   Institute; Hospital del Mar; University of Valencia
RP Ros, E (corresponding author), Univ Barcelona, Hosp Clin, Endocrinol & Nutr Serv, Lipid Clin, Barcelona, Spain.
EM eros@clinic.ub.es
RI Corella, Dolores/L-9888-2014; Martínez-González, Marina/R-6165-2016;
   Estruch, Ramon/AAZ-3723-2020; Martinez-Gonzalez, Miguel/AAE-7669-2019;
   Martinez Hernandez, J Alfredo/K-8709-2014; Fito Colomer,
   Montse/C-1822-2012; Salas-Salvado, Jordi/C-7229-2017
OI Martinez Hernandez, J Alfredo/0000-0001-5218-6941; Ros,
   Emilio/0000-0002-2573-1294; Fito Colomer, Montse/0000-0002-1817-483X;
   Salas-Salvado, Jordi/0000-0003-2700-7459; Martinez-Gonzalez, Miguel
   A./0000-0002-3917-9808
FU official funding agency for Biomedical Research of the Spanish
   Government; Instituto de Salud Carlos III (ISCII); Centro Nacional de
   Investigaciones Cardiovasculares [CNIC 06/2007]; ISCIII;  [RTIC
   003/140];  [RTIC RD 06/0045]
FX The IUNS and the 20th ICN wish to thank the California Walnut Commission
   and Mead Johnson Nutrition for generously providing educational grants
   to support the publication and distribution of proceedings from the 20th
   ICN. The contents of this supplement are solely the responsibility of
   the authors and do not necessarily represent official views of the IUNS.
   The supplement coordinators were Angel Gil, Ibrahim Elmadfa, and Alfredo
   Martinez The supplement coordinators had no conflicts of interest to
   disclose. The PREDIMED study was supported by the official funding
   agency for Biomedical Research of the Spanish Government, Instituto de
   Salud Carlos III (ISCII), through grants provided to research networks
   specifically developed for the study: grants RTIC 003/140 and RTIC RD
   06/0045, CIBER Fisiopatologia de la Obesidad y Nutricion (CIBERobn) and
   a grant from Centro Nacional de Investigaciones Cardiovasculares CNIC
   06/2007, ISCIII.
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NR 46
TC 280
Z9 306
U1 1
U2 49
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 2161-8313
EI 2156-5376
J9 ADV NUTR
JI Adv. Nutr.
PD MAY
PY 2014
VL 5
IS 3
BP 330S
EP 336S
DI 10.3945/an.113.005389
PG 7
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA AI5CV
UT WOS:000336883900017
PM 24829485
OA Green Published, Bronze, Green Submitted
DA 2025-06-11
ER

PT J
AU Suba, Z
AF Suba, Zsuzsanna
TI Circulatory Estrogen Level Protects Against Breast Cancer in Obese Women
SO RECENT PATENTS ON ANTI-CANCER DRUG DISCOVERY
LA English
DT Review
DE Androgen; breast cancer risk; estrogen; insulin resistance; menopause;
   metabolic syndrome; obesity; type-2 diabetes; visceral adiposity
ID POLYCYSTIC-OVARY-SYNDROME; GROWTH-FACTOR-I; HORMONE-REPLACEMENT THERAPY;
   BODY-FAT DISTRIBUTION; YOUNG PREMENOPAUSAL WOMEN; INSULIN-RESISTANCE;
   METABOLIC SYNDROME; ADIPOSE-TISSUE; OXIDATIVE STRESS; RECEPTOR-ALPHA
AB Literary data suggest apparently ambiguous interaction between menopausal status and obesity-associated breast cancer risk based on the principle of the carcinogenic capacity of estrogen. Before menopause, breast cancer incidence is relatively low and adiposity is erroneously regarded as a protective factor against this tumor conferred by the obesity associated defective estrogen-synthesis. By contrast, in postmenopausal cases, obesity presents a strong risk factor for breast cancer being mistakenly attributed to the presumed excessive estrogen-production of their adipose-tissue mass. Obesity is associated with dysmetabolism and endangers the healthy equilibrium of sexual hormone-production and regular menstrual cycles in women, which are the prerequisites not only for reproductive capacity but also for somatic health. At the same time, literary data support that anovulatory infertility is a very strong risk for breast cancer in young women either with or without obesity. In the majority of premenopausal women, obesity associated insulin resistance is moderate and may be counteracted by their preserved circulatory estrogen level. Consequently, it is not obesity but rather the still sufficient estrogen-level, which may be protective against breast cancer in young adult females. In obese older women, never using hormone replacement therapy (HRT) the breast cancer risk is high, which is associated with their continuous estrogen loss and increasing insulin-resistance. By contrast, obese postmenopausal women using HRT, have a decreased risk for breast cancer as the protective effect of estrogen-substitution may counteract to their obesity associated systemic alterations. The revealed inverse correlation between circulatory estrogen-level and breast cancer risk in obese women should advance our understanding of breast cancer etiology and promotes primary prevention measures. New patents recommend various methods for the prevention and treatment of obesity-related systemic disorders and the associated breast cancer.
C1 [Suba, Zsuzsanna] Natl Inst Oncol, H-1122 Budapest, Hungary.
C3 National Institute of Oncology Hungary
RP Suba, Z (corresponding author), Natl Inst Oncol, Surg & Mol Tumor Pathol Ctr, Rath Gyorgy Str 7-9, H-1122 Budapest, Hungary.
EM subazdr@gmail.com
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NR 186
TC 38
Z9 41
U1 0
U2 11
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1574-8928
EI 2212-3970
J9 RECENT PAT ANTI-CANC
JI Recent Patents Anti-Canc. Drug Discov.
PD MAY
PY 2013
VL 8
IS 2
BP 154
EP 167
PG 14
WC Oncology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Pharmacology & Pharmacy
GA 163XR
UT WOS:000320372400004
PM 23061769
DA 2025-06-11
ER

PT J
AU Sieruo, M
   Bluck, LJC
AF Sieruo, Mario
   Bluck, Les J. C.
TI In vivo nitric oxide synthesis, insulin sensitivity, and asymmetric
   dimethylarginine in obese subjects without and with metabolic syndrome
SO METABOLISM-CLINICAL AND EXPERIMENTAL
LA English
DT Article
ID FLOW-MEDIATED DILATION; ENDOTHELIAL FUNCTION; CARDIOVASCULAR RISK;
   OXIDATIVE STRESS; RESISTANCE; DYSFUNCTION; OVERWEIGHT; DISEASE; GLUCOSE;
   WOMEN
AB Metabolic syndrome (MetSyn) is associated with impaired endothelial function. Here the association between nitric oxide (NO) production and insulin sensitivity (Si) in obese subjects with and without MetSyn was evaluated. The relationship between NO production and asymmetric dimethylarginine (ADMA) was also explored. Seven healthy normal-weight subjects (male/female [M/F], 3/4; age, 27.4 +/- 10.9 years; body mass index [BMI], 21.9 +/- 2.2 kg/m(2)), 7 obese subjects without MetSyn (M/F, 1/6; age, 48.0 +/- 8.0 years; BMI, 34.5 +/- 2.3 kg/m(2)), and 7 with MetSyn (M/F, 3/4; age, 48.0 +/- 10.7 years; BMI, 33.4 +/- 2.9 kg/m(2)) were recruited. Body composition and cardiometabolic functions (blood pressure, glucose, insulin, triglycerides, total cholesterol, high-density lipoprotein, ADMA) were measured. A frequent sampling intravenous glucose tolerance test was performed to measure Si. A novel stable isotopic method was used to measure in vivo rates of NO production. The NO production was lower in obese subjects with MetSyn compared with normal-weight subjects and obese subjects without MetSyn. Similarly, Si was significantly lower in obesity, both without and with MetSyn, compared with the control group. A significant direct association was found between NO synthesis and Si (rho = 0.47, P = .03). Circulating levels of ADMA were significantly higher in the obese group with MetSyn. A nonsignificant negative trend between ADMA and NO synthesis was observed. The association between Si and NO production suggests a close mechanistic link between endothelial function and insulin signaling. The results may be highly informative for the development of controlled longitudinal interventions to improve endothelial and metabolic regulation. (C) 2012 Elsevier Inc. All rights reserved.
C1 [Sieruo, Mario; Bluck, Les J. C.] Elsie Widdouison, MRC Human Nutr Res, Lab, Cambridge CB1 9NL, England.
C3 UK Research & Innovation (UKRI); Medical Research Council UK (MRC); MRC
   Human Nutrition Research
RP Bluck, LJC (corresponding author), Elsie Widdouison, MRC Human Nutr Res, Lab, Fulbourn Rd, Cambridge CB1 9NL, England.
EM Les.Bluck@mrc-hnr.cam.ac.uk
RI Siervo, Mario/AAB-9302-2019
OI Siervo, Mario/0000-0001-5515-0944
FU Medical Research Council; MRC [MC_UP_A090_1005] Funding Source: UKRI
FX This study was funded by the Medical Research Council.
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NR 55
TC 19
Z9 20
U1 0
U2 4
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0026-0495
EI 1532-8600
J9 METABOLISM
JI Metab.-Clin. Exp.
PD MAY
PY 2012
VL 61
IS 5
BP 680
EP 688
DI 10.1016/j.metabol.2011.10.003
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 936VH
UT WOS:000303617600011
PM 22146092
DA 2025-06-11
ER

PT J
AU Pathomwichaiwat, T
   Jinatongthai, P
   Prommasut, N
   Ampornwong, K
   Rattanavipanon, W
   Nathisuwan, S
   Thakkinstian, A
AF Pathomwichaiwat, Thanika
   Jinatongthai, Peerawat
   Prommasut, Napattaoon
   Ampornwong, Kanyarat
   Rattanavipanon, Wipharak
   Nathisuwan, Surakit
   Thakkinstian, Ammarin
TI Effects of turmeric (Curcuma longa) supplementation on glucose
   metabolism in diabetes mellitus and metabolic syndrome: An umbrella
   review and updated meta-analysis
SO PLOS ONE
LA English
DT Review
ID RANDOMIZED CONTROLLED-TRIAL; DOUBLE-BLIND; LIPID PROFILE; GLYCEMIC
   STATUS; PIPERINE COMBINATION; SYSTEMATIC REVIEWS; OXIDATIVE STRESS;
   PARALLEL-GROUP; NANO-CURCUMIN; TYPE-2
AB AimsThis study aims to comprehensively review the existing evidence and conduct analysis of updated randomized controlled trials (RCTs) of turmeric (Curcuma longa, CL) and its related bioactive compounds on glycemic and metabolic parameters in patients with type 2 diabetes (T2DM), prediabetes, and metabolic syndrome (MetS) together with a sub-group analysis of different CL preparation forms.MethodsAn umbrella review (UR) and updated systematic reviews and meta-analyses (SRMAs) were conducted to evaluate the effects of CL compared with a placebo/standard treatment in adult T2DM, prediabetes, and MetS. The MEDLINE, Embase, The Cochrane Central Register of Control Trials, and Scopus databases were searched from inception to September 2022. The primary efficacy outcomes were hemoglobin A1C (HbA1C) and fasting blood glucose (FBG). The corrected covered area (CCA) was used to assess overlap. Mean differences were pooled across individual RCTs using a random-effects model. Subgroup and sensitivity analyses were performed for various CL preparation forms.Results Fourteen SRMAs of 61 individual RCTs were included in the UR. The updated SRMA included 28 studies. The CCA was 11.54%, indicating high overlap across SRMAs. The updated SRMA revealed significant reduction in FBG and HbA1C with CL supplementation, obtaining a mean difference (95% confidence interval [CI]) of -8.129 (-12.175, -4.084) mg/dL and -0.134 (-0.304, -0.037) %, respectively. FBG and HbA1C levels decreased with all CL preparation forms as did other metabolic parameters levels. The results of the sensitivity and subgroup analyses were consistent with those of the main analysis.ConclusionCL supplementation can significantly reduce FBG and HbA1C levels and other metabolic parameters in T2DM and mitigate related conditions, including prediabetes and MetS.
C1 [Pathomwichaiwat, Thanika] Mahidol Univ, Fac Pharm, Dept Pharmaceut Bot, Bangkok, Thailand.
   [Jinatongthai, Peerawat] Ubon Ratchathani Univ, Fac Pharmaceut Sci, Pharm Practice Div, Ubon Ratchathani, Thailand.
   [Prommasut, Napattaoon; Ampornwong, Kanyarat; Rattanavipanon, Wipharak; Nathisuwan, Surakit] Mahidol Univ, Fac Pharm, Dept Pharm, Bangkok, Thailand.
   [Thakkinstian, Ammarin] Mahidol Univ, Fac Med, Dept Clin Epidemiol & Biostat, Dept Clin Epidemiol & Biostat, Bangkok, Thailand.
C3 Mahidol University; Ubon Ratchathani University; Mahidol University;
   Mahidol University
RP Jinatongthai, P (corresponding author), Ubon Ratchathani Univ, Fac Pharmaceut Sci, Pharm Practice Div, Ubon Ratchathani, Thailand.; Nathisuwan, S (corresponding author), Mahidol Univ, Fac Pharm, Dept Pharm, Bangkok, Thailand.
EM peerawat.j@ubu.ac.th; surakit.nat@mahidol.ac.th
RI Thakkinstian, Ammarin/J-4788-2019; Nathisuwan, Surakit/AAJ-5622-2020;
   Rattanavipanon, Wipharak/GPX-0994-2022
OI Jinatongthai, Peerawat/0000-0002-7954-2480; Pathomwichaiwat,
   Thanika/0000-0003-3659-2127
FU National Research Council of Thailand [N42A640323]
FX This study was supported by the National Research Council of Thailand
   (N42A640323). The funders had no role in study design, data collection
   and analysis, decision to publish, or preparation of the manuscript.
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NR 80
TC 5
Z9 5
U1 1
U2 5
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JUL 20
PY 2023
VL 18
IS 7
AR e0288997
DI 10.1371/journal.pone.0288997
PG 21
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA N1YH0
UT WOS:001035045000034
PM 37471428
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Porfirio, MC
   de Almeida, JPG
   Stornelli, M
   Giovinazzo, S
   Purper-Ouakil, D
   Masi, G
AF Porfirio, Maria-Cristina
   Gomes de Almeida, Juliana Paula
   Stornelli, Maddalena
   Giovinazzo, Silvia
   Purper-Ouakil, Diane
   Masi, Gabriele
TI Can melatonin prevent or improve metabolic side effects during
   antipsychotic treatments?
SO NEUROPSYCHIATRIC DISEASE AND TREATMENT
LA English
DT Article
DE melatonin; metabolic syndrome; second-generation antipsychotics
ID BROWN ADIPOSE-TISSUE; INDUCED WEIGHT-GAIN; SUPRACHIASMATIC NUCLEUS;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; BLOOD-PRESSURE; LIPID PROFILE;
   PINEAL GLANDS; DOUBLE-BLIND; CHOLESTEROL
AB In the last two decades, second-generation antipsychotics (SGAs) were more frequently used than typical antipsychotics for treating both psychotic and nonpsychotic psychiatric disorders in both children and adolescents, because of their lower risk of adverse neurological effects, that is, extrapyramidal symptoms. Recent studies have pointed out their effect on weight gain and increased visceral adiposity as they induce metabolic syndrome. Patients receiving SGAs often need to be treated with other substances to counteract metabolic side effects. In this paper, we point out the possible protective effect of add-on melatonin treatment in preventing, mitigating, or even reversing SGAs metabolic effects, improving quality of life and providing safer long-term treatments in pediatric patients. Melatonin is an endogenous indolamine secreted during darkness by the pineal gland; it plays a key role in regulating the circadian rhythm, generated by the suprachiasmatic nuclei (SCN) of the hypothalamus, and has many other biological functions, including chronobiotic, antioxidant and neuroprotective properties, anti-inflammatory and free radical scavenging effects, and diminishing oxidative injury and fat distribution. It has been hypothesized that SGAs cause adverse metabolic effects that may be restored by nightly administration of melatonin because of its influence on autonomic and hormonal outputs. Interestingly, atypical anti-psychotics (AAPs) can cause several sleep disorders, and circadian misalignment can influence hormones involved in the metabolic regulation, such as insulin, leptin, and ghrelin; furthermore, a relationship between obesity and sleep curtailment has been demonstrated, as well as sleep deprivation in rats has been associated with hyperphagia. Metabolic effects of melatonin, both central and peripheral, direct and indirect, target most metabolic disorders reported during and after SGA treatment in children, adolescents, and adults. Further systematic studies on psychiatric patients are needed to explore the effect of add-on melatonin on metabolic side effects of SGAs, independent of energy intake, diet, and exercise.
C1 [Porfirio, Maria-Cristina; Stornelli, Maddalena; Giovinazzo, Silvia] Tor Vergata Univ Rome, Unit Child Neurol & Psychiat, Viale Oxford 81, I-00133 Rome, Italy.
   [Gomes de Almeida, Juliana Paula] Irmandade Santa Casa de Misericordia Hosp Sao Pau, Unit Child Neurol, Sao Paulo, Brazil.
   [Purper-Ouakil, Diane] St Eloi Hosp, Unit Child & Adolescent Psychiat, Montpellier, France.
   [Masi, Gabriele] IRCCS Stella Maris, Sci Inst Child Neurol & Psychiat, Pisa, Italy.
C3 University of Rome Tor Vergata; Universite de Montpellier; CHU de
   Montpellier; IRCCS Fondazione Stella Maris
RP Giovinazzo, S (corresponding author), Tor Vergata Univ Rome, Unit Child Neurol & Psychiat, Viale Oxford 81, I-00133 Rome, Italy.
EM neuro.infantile@ptvonline.it
RI Purper-Ouakil, Diane/AAC-5024-2019; Purper-Ouakil, Diane/HOC-7568-2023;
   Masi, Gabriele/K-2643-2018
OI Purper-Ouakil, Diane/0000-0003-0454-1579; Masi,
   Gabriele/0000-0001-7770-926X
FU Italian Ministry of Health
FX This study was in part funded by the Italian Ministry of Health.
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NR 81
TC 15
Z9 17
U1 1
U2 8
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
EI 1178-2021
J9 NEUROPSYCH DIS TREAT
JI Neuropsychiatr. Dis. Treat.
PY 2017
VL 13
BP 2167
EP 2174
DI 10.2147/NDT.S127564
PG 8
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA FD1QK
UT WOS:000407311600001
PM 28860773
OA Green Submitted, gold, Green Published
DA 2025-06-11
ER

PT J
AU Blond, E
   Rieusset, J
   Alligier, M
   Lambert-Porcheron, S
   Bendridi, N
   Gabert, L
   Chetiveaux, M
   Debard, C
   Chauvin, MA
   Normand, S
   Roth, H
   de Gouville, AC
   Krempf, M
   Vidal, H
   Goudable, J
   Laville, M
AF Blond, E.
   Rieusset, J.
   Alligier, M.
   Lambert-Porcheron, S.
   Bendridi, N.
   Gabert, L.
   Chetiveaux, M.
   Debard, C.
   Chauvin, M. -A.
   Normand, S.
   Roth, H.
   de Gouville, A. -C.
   Krempf, M.
   Vidal, H.
   Goudable, J.
   Laville, M.
CA Niacin Study Grp
TI Nicotinic Acid Effects on Insulin Sensitivity and Hepatic Lipid
   Metabolism: An In Vivo to In Vitro Study
SO HORMONE AND METABOLIC RESEARCH
LA English
DT Article
DE nicotinic acid; hepatic insulin-resistance; diacylglycerol; DGAT2
   inhibition; euglycemic hyperinsulinemic clamp; VLDL-TG rate production
ID NIACIN; RESISTANCE; REDUCTION; MECHANISM; DGAT2; STEATOSIS; RECEPTORS;
   SECRETION; OXIDATION; STRESS
AB Our aim was to characterize the effects and the underlying mechanisms of the lipid-regulating agent Niaspan (R) on both insulin action and triglyceride decrease in 20 nondiabetic, dyslipidemic men with metabolic syndrome receiving Niaspan (R) (2g/day) or placebo for 8 weeks in a randomized, cross-over study. The effects on plasma lipid profile were characterized at the beginning and the end of each treatment period; insulin sensitivity was assessed using the 2-step euglycemic hyperinsulinemic clamp and VLDL-triglyceride turnover by measuring plasma glycerol enrichment, both at the end of each treatment period. The mechanism of action of nicotinic acid was studied in HuH7 and mouse primary hepatocytes. Lipid profile was improved after Niaspan (R) treatment with a significant-28% decrease in triglyceride levels, a(+) 17 % increase in HDL-C concentration and unchanged levels of fasting nonesterified fatty acid. VLDL-triglyceride production rate was markedly reduced after Niaspan (R) (-68%). However, the treatment induced hepatic insulin resistance, as assessed by reduced inhibition of endogenous glucose production by insulin (0.7 +/- 0.4 vs. 1.0 +/- 0.5 mg/kg.min, p < 0.05) and decrease in fasting hepatic insulin sensitivity index (4.8 +/- 1.8 vs. 3.2 +/- 1.6, p < 0.05) in the Niaspan (R) condition. Nicotinic acid also reduced insulin action in HuH7 and primary hepatocytes, independently of the activation of hepatic PKC epsilon. This effect was associated with an increase in diacylglycerol and a decrease in triglyceride contents that occurred in the absence of modification of DGAT2 expression and activity. Eight weeks of Niaspan (R) treatment in dyslipidemic patients with metabolic syndrome induce hepatic insulin resistance. The mechanism could involve an accumulation of diacylglycerol and an alteration of insulin signaling in hepatocytes.
C1 [Blond, E.; Lambert-Porcheron, S.; Normand, S.; Vidal, H.; Goudable, J.; Laville, M.] Hosp Civils Lyon, Res Ctr Human Nutr Rhone Alpes, Pierre Benite, France.
   [Blond, E.; Lambert-Porcheron, S.; Normand, S.; Vidal, H.; Goudable, J.; Laville, M.] Hosp Civils Lyon, CENS Ctr European Nutr Safety & Hlth, Pierre Benite, France.
   [Blond, E.; Rieusset, J.; Alligier, M.; Bendridi, N.; Gabert, L.; Debard, C.; Chauvin, M. -A.; Vidal, H.; Goudable, J.; Laville, M.] Univ Lyon 1, INRA 1235, CarMeN Lab, INSERM,U1060, Oullins, France.
   [Chetiveaux, M.; Krempf, M.] INSERM, U915, F-44000 Nantes, France.
   [Chetiveaux, M.; Krempf, M.] Nantes Res Ctr Human Nutr, F-44000 Nantes, France.
   [Roth, H.] CHU Grenoble, Res Ctr Human Nutr Rhone Alpes, F-38043 Grenoble, France.
   [de Gouville, A. -C.] GlaxoSmithKline, Les Ulis, France.
C3 CHU Lyon; CHU Lyon; Institut National de la Sante et de la Recherche
   Medicale (Inserm); Universite Claude Bernard Lyon 1; INRAE; Institut
   National de la Sante et de la Recherche Medicale (Inserm); CHU Grenoble
   Alpes; Communaute Universite Grenoble Alpes; Universite Grenoble Alpes
   (UGA); GlaxoSmithKline; Glaxosmithkline United Kingdom
RP Blond, E (corresponding author), Ctr Hosp Lyon Sud, Ctr Rech Nutr Humaine, Pavillon Med Batiment 1B 165 Chemin Grand Revoyet, F-69495 Pierre Benite, France.
EM emilie.blond@chu-lyon.fr
RI Chetiveaux, Maud/D-3958-2015; VIDAL, Hubert/M-6674-2017; Rieusset,
   Jennifer/F-1595-2018
OI ROTH, Hubert/0000-0002-1980-3220; Krempf, Michel/0000-0002-4353-9511;
   MEILLER, Laure/0000-0002-9702-8899; VIDAL, Hubert/0000-0002-9467-0317;
   Lab, Carmen/0000-0002-5935-3236; Rieusset, Jennifer/0000-0002-1587-2253;
   Carmen, Team2/0000-0001-9867-5724; BENDRIDI, Nadia/0000-0003-0456-7007;
   Carmen, Team1/0000-0003-4234-1746
FU GlaxoSmithKline, Les Ulis, France
FX This study was supported by research grant support from GlaxoSmithKline,
   Les Ulis, France. Except Anne Charlotte de Gouville, who has affiliation
   and financial arrangement with GlaxoSmithKline, Les Ulis, France, other
   authors have no financial arrangement or affiliation with
   GlaxoSmithKline, Les Ulis, France.
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NR 36
TC 23
Z9 23
U1 0
U2 10
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0018-5043
EI 1439-4286
J9 HORM METAB RES
JI Horm. Metab. Res.
PD JUN
PY 2014
VL 46
IS 6
BP 390
EP 396
DI 10.1055/s-0034-1372600
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA AI3BO
UT WOS:000336733700003
PM 24806747
DA 2025-06-11
ER

PT J
AU Auvinen, HE
   Romijn, JA
   Biermasz, NR
   Pijl, H
   Havekes, LM
   Smit, JW
   Rensen, PCN
   Pereira, AM
AF Auvinen, Hanna E.
   Romijn, Johannes A.
   Biermasz, Nienke R.
   Pijl, Hanno
   Havekes, Louis M.
   Smit, Johannes Wa
   Rensen, Patrick C. N.
   Pereira, Alberto M.
TI The effects of high fat diet on the basal activity of the
   hypothalamus-pituitary-adrenal axis in mice
SO JOURNAL OF ENDOCRINOLOGY
LA English
DT Article
ID CORTICOTROPIN-RELEASING HORMONE; METABOLIC SYNDROME; INDUCED OBESITY;
   C57BL/6J MICE; LEPTIN RESISTANCE; STRIA TERMINALIS; CHRONIC STRESS;
   MESSENGER-RNA; BED NUCLEUS; NEURONS
AB Alterations in hypothalamus-pituitary-adrenal (HPA) axis activity have been linked to the development of the metabolic syndrome (MetS). Common features of the MetS, like insulin resistance and obesity, are reproducibly induced by high fat diet (HFD) in animal models of diet-induced obesity. These models, hampered by methodological differences, reveal conflicting results with respect to HPA axis activation. This study was aimed to evaluate in detail nonstressed diurnal HPA axis activity in mice during obesity development. Male C57Bl/6J mice were fed high or low fat diet for 12 weeks. HPA axis activity was evaluated by plasma corticosterone concentrations (at 0700, 1200, and 1800 h), corticotropin-releasing hormone (CRH), and glucocorticoid receptor (GR) mRNA expression in the hippocampus, amygdala, and hypothalamus, and 11 beta-hydroxysteroid dehydrogenase type-1 and -2 (11 beta-HSD-1 and -2) expression in adipose tissue and liver. Within 1 week, the HFD induced obesity and decreased corticosterone levels at 1200 and 1800 h, which persisted throughout the experiment. Twelve weeks of HFD decreased CRH mRNA in the paraventricular nucleus (PVN) and amygdala and GR mRNA in the PVN at 0900 h. At 1800 h, CRH mRNA expression increased in the PVN and amygdala, and GR mRNA increased in the CA1 region. 11 beta-HSD-1 expressions decreased in gonadal, visceral, and subcutaneous adipose tissues at 0900 and 1800 h, whereas hepatic 11 beta-HSD-1 expression increased at 1800 h, whereas 11 beta-HSD-2 expression was unaffected. The HFD induces complex changes in the diurnal regulation of the different components of the HPA axis. These changes are not unequivocally characterized by increased, but rather by decreased HPA axis activity. Journal of Endocrinology (2012) 214, 191-197
C1 [Auvinen, Hanna E.; Romijn, Johannes A.; Biermasz, Nienke R.; Pijl, Hanno; Havekes, Louis M.; Smit, Johannes Wa; Rensen, Patrick C. N.; Pereira, Alberto M.] Leiden Univ, Med Ctr, Dept Endocrinol & Metab Dis, NL-2300 RC Leiden, Netherlands.
   [Havekes, Louis M.] TNO Metab Hlth Res, Gaubius Lab, NL-2333 CK Leiden, Netherlands.
C3 Leiden University - Excl LUMC; Leiden University; Leiden University
   Medical Center (LUMC); Netherlands Organization Applied Science Research
RP Auvinen, HE (corresponding author), Leiden Univ, Med Ctr, Dept Endocrinol & Metab Dis, Room C5-R61,Albinusdreef 2,POB 9600, NL-2300 RC Leiden, Netherlands.
EM h.e.auvinen@lumc.nl
RI Biermasz, Nienke/ABE-9436-2021; smit, johannes/H-8091-2014; Pereira,
   Alberto M./Q-7175-2017; Rensen, Patrick/D-7176-2018; Pijl,
   Hanno/W-8719-2018
OI smit, johannes/0000-0003-1052-9314; Pereira, Alberto
   M./0000-0002-1194-9866; Rensen, Patrick/0000-0002-8455-4988; Pijl,
   Hanno/0000-0002-3076-1551
FU Netherlands Heart Foundation [NHS2009T038]
FX Patrick C N Rensen is an established investigator of the Netherlands
   Heart Foundation (grant number NHS2009T038).
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NR 38
TC 45
Z9 53
U1 0
U2 8
PU BIOSCIENTIFICA LTD
PI BRISTOL
PA EURO HOUSE, 22 APEX COURT WOODLANDS, BRADLEY STOKE, BRISTOL BS32 4JT,
   ENGLAND
SN 0022-0795
EI 1479-6805
J9 J ENDOCRINOL
JI J. Endocrinol.
PD AUG
PY 2012
VL 214
IS 2
BP 191
EP 197
DI 10.1530/JOE-12-0056
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 976CR
UT WOS:000306558600009
PM 22619233
OA Bronze
DA 2025-06-11
ER

PT J
AU Zorlu, A
   Yucel, H
   Bektasoglu, G
   Turkdogan, KA
   Eryigit, U
   Sarikaya, S
   Ege, MR
   Tandogan, I
   Yilmaz, MB
AF Zorlu, Ali
   Yucel, Hasan
   Bektasoglu, Gokhan
   Turkdogan, Kenan Ahmet
   Eryigit, Umut
   Sarikaya, Savas
   Ege, Meltem Refiker
   Tandogan, Izzet
   Yilmaz, Mehmet Birhan
TI Increased γ-glutamyl transferase levels predict early mortality in
   patients with acute pulmonary embolism
SO AMERICAN JOURNAL OF EMERGENCY MEDICINE
LA English
DT Article
ID RIGHT-VENTRICULAR DYSFUNCTION; TRICUSPID REGURGITATION; HEART-FAILURE;
   CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; PROGNOSTIC VALUE; SERUM;
   RISK; GLUTAMYLTRANSFERASE; ADULTS
AB Background: Increased gamma-glutamyl transferase (GGT) level is associated with increased oxidative stress, all-cause mortality, the development of cardiovascular disease, and metabolic syndrome. However, its role in acute pulmonary embolism (PE) is unknown. In this study, we aimed to investigate the relationship between GGT and early mortality in patients with acute PE.
   Methods: A total of 127 consecutive patients with confirmed PE were evaluated. The optimal cutoff value of GGT to predict early mortality was measured as more than 55 IU/L with 94.4% sensitivity and 66.1% specificity. Patients with acute PE were categorized prospectively as having no increased (group I) or increased (group II) GGT based on a cutoff value.
   Results: Of these 127 patients, 18 patients (14.2%) died during follow-up. Among these 18 patients, 1 (1.4%) patient was in group I, and 17 (30.9%) patients were in group II (P < .001). gamma-Glutamyl transferase level on admission, presence of shock, heart rate, oxygen saturation, right ventricular dilatation/hypokinesia, main pulmonary artery involvement, troponin I, alanine aminotransferase, alkaline phosphatase, and creatinine levels were found to have prognostic significance in univariate analysis. In the multivariate Cox proportional hazards model, GGT level on admission (hazard ratio [HR], 1.015; P = .017), presence of shock (HR, 15.124; P = .005), age (HR, 1.107; P = .010), and heart rate (HR, 1.101; P = .032) remained associated with an increased risk of acute PE-related early mortality after the adjustment of other potential confounders.
   Conclusions: We have shown that a high GGT level is associated with worse hemodynamic parameters, and it seems that GGT helps risk stratification in patients with acute PE. (C) 2012 Elsevier Inc. All rights reserved.
C1 [Zorlu, Ali; Yucel, Hasan; Sarikaya, Savas; Tandogan, Izzet; Yilmaz, Mehmet Birhan] Cumhuriyet Univ, Sch Med, Dept Cardiol, TR-58140 Sivas, Turkey.
   [Bektasoglu, Gokhan] Uzunkopru State Hosp, Dept Cardiol, Edirne, Turkey.
   [Turkdogan, Kenan Ahmet] Cumhuriyet Univ, Sch Med, Dept Emergency, TR-58140 Sivas, Turkey.
   [Eryigit, Umut] Karadeniz Tech Univ, Dept Emergency, Trabzon, Turkey.
   [Ege, Meltem Refiker] Yalova State Hosp, Dept Cardiol, Yalova, Turkey.
C3 Cumhuriyet University; Uzunkopru State Hospital; Cumhuriyet University;
   Karadeniz Technical University; Yalova State Hospital
RP Zorlu, A (corresponding author), Cumhuriyet Univ, Sch Med, Dept Cardiol, TR-58140 Sivas, Turkey.
EM dralizorlu@gmail.com
RI Yilmaz, Mehmet Birhan/Y-1372-2019; BEKTASOGLU, GOKHAN/ABC-2975-2020
OI Yilmaz, Mehmet Birhan/0000-0002-8169-8628; Refiker,
   Meltem/0000-0002-0621-6000; BEKTASOGLU, GOKHAN/0000-0002-4571-7908
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NR 27
TC 8
Z9 11
U1 0
U2 2
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0735-6757
EI 1532-8171
J9 AM J EMERG MED
JI Am. J. Emerg. Med.
PD JUL
PY 2012
VL 30
IS 6
BP 908
EP 915
DI 10.1016/j.ajem.2011.12.040
PG 8
WC Emergency Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine
GA 966BL
UT WOS:000305811600012
PM 22386346
DA 2025-06-11
ER

PT J
AU Egert, S
   Bosy-Westphal, A
   Seiberl, J
   Kürbitz, C
   Settler, U
   Plachta-Danielzik, S
   Wagner, AE
   Frank, J
   Schrezenmeir, J
   Rimbach, G
   Wolffram, S
   Müller, MJ
AF Egert, Sarah
   Bosy-Westphal, Anja
   Seiberl, Jasmin
   Kuerbitz, Claudia
   Settler, Uta
   Plachta-Danielzik, Sandra
   Wagner, Anika E.
   Frank, Jan
   Schrezenmeir, Juergen
   Rimbach, Gerald
   Wolffram, Siegfried
   Mueller, Manfred J.
TI Quercetin reduces systolic blood pressure and plasma oxidised
   low-density lipoprotein concentrations in overweight subjects with a
   high-cardiovascular disease risk phenotype: a double-blinded,
   placebo-controlled cross-over study
SO BRITISH JOURNAL OF NUTRITION
LA English
DT Article
DE Quercetin; Blood pressure; Inflammation; Oxidised LDL; CVD
ID NECROSIS-FACTOR-ALPHA; FAT OXIDATION; GREEN TEA; ENERGY-EXPENDITURE;
   METABOLIC SYNDROME; FLAVONOID INTAKE; MODULATION; EXPRESSION; OBESITY;
   RICH
AB Regular consumption of flavonoids may reduce the risk for CVD. However, the effects of individual flavonoids, for example, quercetin, remain unclear. The present study was undertaken to examine the effects of quercetin supplementation on blood pressure, lipid metabolism, markers of oxidative stress, inflammation, and body composition in an at-risk population of ninety-three overweight or obese subjects aged 25-65 years with metabolic syndrome traits. Subjects were randomised to receive 150 mg quercetin/d in a double-blinded, placebo-controlled cross-over trial with 6-week treatment periods separated by a 5-week washout period. Mean fasting plasma quercetin concentrations increased from 71 to 269 nmol/l (P<0-001) during quercetin treatment. In contrast to placebo, quercetin decreased systolic blood pressure (SBP) by 2.6 mmHg (P<0.01) in the entire study group, by 2-9 mmHg (P<0.01) in the subgroup of hypertensive subjects and by 3-7 mmHg (P<0.001) in the subgroup of younger adults aged 25-50 years. Quercetin decreased serum HDL-cholesterol concentrations (P<0.001), while total cholesterol, TAG and the LDL:HDL-cholesterol and TAG:HDL-cholesterol ratios were unaltered. Quercetin significantly decreased plasma concentrations of atherogenic oxidised LDL, but did not affect TNF-alpha and C-reactive protein when compared with placebo. Quercetin supplementation had no effects on nutritional status. Blood parameters of liver and kidney function, haematology and serum electrolytes did not reveal any adverse effects of quercetin. In conclusion, quercetin reduced SBP and plasma oxidised LDL concentrations in overweight subjects with a high-CVD risk phenotype. Our findings provide further evidence that quercetin may provide protection against CVD.
C1 [Egert, Sarah; Bosy-Westphal, Anja; Seiberl, Jasmin; Kuerbitz, Claudia; Settler, Uta; Plachta-Danielzik, Sandra; Mueller, Manfred J.] Univ Kiel, Dept Human Nutr, Inst Human Nutr & Food Sci, D-24105 Kiel, Germany.
   [Wagner, Anika E.; Frank, Jan; Rimbach, Gerald] Univ Kiel, Dept Food Sci, Inst Human Nutr & Food Sci, D-24118 Kiel, Germany.
   [Schrezenmeir, Juergen] Fed Res Inst Nutr & Food, Max Rubner Inst, D-24103 Kiel, Germany.
   [Wolffram, Siegfried] Univ Kiel, Inst Anim Nutr Physiol & Metab, D-24118 Kiel, Germany.
C3 University of Kiel; University of Kiel; University of Kiel
RP Müller, MJ (corresponding author), Univ Kiel, Dept Human Nutr, Inst Human Nutr & Food Sci, D-24105 Kiel, Germany.
EM mmueller@nutrfoodsc.uni-kiel.de
RI Wagner, Anika/AAE-3579-2019; Rimbach, Gerald/A-7178-2011; Frank,
   Jan/A-1763-2009
OI Wagner, Anika/0000-0003-3047-7128; Rimbach, Gerald/0000-0001-7888-4684;
   Frank, Jan/0000-0002-7548-5829
FU German Federal Ministry of Education and Research [BMBF 0313856A];
   Functional Foods for Vascular Health; Nutraceuticals to Personalised
   Diets
FX The project was financially supported by the German Federal Ministry of
   Education and Research (BMBF 0313856A) within the project 'Functional
   Foods for Vascular Health - from Nutraceuticals to Personalised Diets'.
   None of the authors has any personal or financial conflicts of interest
   in the publication of this paper.
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NR 48
TC 438
Z9 463
U1 4
U2 65
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1145
EI 1475-2662
J9 BRIT J NUTR
JI Br. J. Nutr.
PD OCT 14
PY 2009
VL 102
IS 7
BP 1065
EP 1074
DI 10.1017/S0007114509359127
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 507PG
UT WOS:000270866100018
PM 19402938
OA Bronze
DA 2025-06-11
ER

PT J
AU Hashim, KN
   Chin, KY
   Ahmad, F
AF Hashim, Khairun-Nisa
   Chin, Kok-Yong
   Ahmad, Fairus
TI The Mechanism of Kelulut Honey in Reversing Metabolic Changes in Rats
   Fed with High-Carbohydrate High-Fat Diet
SO MOLECULES
LA English
DT Article
DE metabolic syndrome; honey; obesity; hyperglycaemia; hyperlipidaemia;
   hypertension
ID P-COUMARIC ACID; STINGLESS BEE HONEY; ENDOTHELIAL DYSFUNCTION; OXIDATIVE
   STRESS; PHENOLIC-COMPOUNDS; ADIPONECTIN LEVELS; OBESE RATS; EXPRESSION;
   LEPTIN; LIVER
AB Metabolic syndrome (MetS) is composed of central obesity, hyperglycemia, dyslipidemia and hypertension that increase an individual's tendency to develop type 2 diabetes mellitus and cardiovascular diseases. Kelulut honey (KH) produced by stingless bee species has a rich phenolic profile. Recent studies have demonstrated that KH could suppress components of MetS, but its mechanisms of action are unknown. A total of 18 male Wistar rats were randomly divided into control rats (C group) (n = 6), MetS rats fed with a high carbohydrate high fat (HCHF) diet (HCHF group) (n = 6), and MetS rats fed with HCHF diet and treated with KH (HCHF + KH group) (n = 6). The HCHF + KH group received 1.0 g/kg/day KH via oral gavage from week 9 to 16 after HCHF diet initiation. Compared to the C group, the MetS group experienced a significant increase in body weight, body mass index, systolic (SBP) and diastolic blood pressure (DBP), serum triglyceride (TG) and leptin, as well as the area and perimeter of adipocyte cells at the end of the study. The MetS group also experienced a significant decrease in serum HDL levels versus the C group. KH supplementation reversed the changes in serum TG, HDL, leptin, adiponectin and corticosterone levels, SBP, DBP, as well as adipose tissue 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta HSD1) level, area and perimeter at the end of the study. In addition, histological observations also showed that KH administration reduced fat deposition within hepatocytes, and prevented deterioration of pancreatic islet and renal glomerulus. In conclusion, KH is effective in preventing MetS by suppressing leptin, corticosterone and 11 beta HSD1 levels while elevating adiponectin levels.
C1 [Hashim, Khairun-Nisa; Ahmad, Fairus] Univ Kebangsaan Malaysia, Fac Med, Dept Anat, Jalan Yaacob Latif, Bandar Tun Razak 56000, Kuala Lumpur, Malaysia.
   [Chin, Kok-Yong] Univ Kebangsaan Malaysia, Fac Med, Dept Pharmacol, Jalan Yaacob Latif, Bandar Tun Razak 56000, Kuala Lumpur, Malaysia.
C3 Universiti Kebangsaan Malaysia; Universiti Kebangsaan Malaysia
RP Ahmad, F (corresponding author), Univ Kebangsaan Malaysia, Fac Med, Dept Anat, Jalan Yaacob Latif, Bandar Tun Razak 56000, Kuala Lumpur, Malaysia.
EM chinkokyong@ppukm.ukm.edu.my; fairusahmad@ukm.edu.my
RI Chin, Kok-Yong/B-6309-2015
OI Chin, Kok-Yong/0000-0001-6628-1552; Ahmad, Fairus/0000-0002-2452-6459
FU Dana Fundamental, Universiti Kebangsaan Malaysia [FF-2020-493]; Geran
   Galakan Penyelidik UKM [GGP-2017-056]
FX This research was funded by Dana Fundamental, Universiti Kebangsaan
   Malaysia (grant no. FF-2020-493) and Geran Galakan Penyelidik UKM (grant
   no. GGP-2017-056).
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NR 95
TC 3
Z9 3
U1 0
U2 5
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1420-3049
J9 MOLECULES
JI Molecules
PD MAR
PY 2023
VL 28
IS 6
AR 2790
DI 10.3390/molecules28062790
PG 22
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA C1RB9
UT WOS:000959763000001
PM 36985762
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Simunovic, M
   Supe-Domic, D
   Karin, Z
   Degoricija, M
   Paradzik, M
   Skrabic, R
   Jukic, A
   Bozic, J
   Skrabic, V
AF Simunovic, Marko
   Supe-Domic, Daniela
   Karin, Zeljka
   Degoricija, Marina
   Paradzik, Martina
   Skrabic, Roko
   Jukic, Andrija
   Bozic, Josko
   Skrabic, Veselin
TI The Relationship of Vitamin D Status, Adherence to the Mediterranean
   Diet, and Physical Activity in Obese Children and Adolescents
SO JOURNAL OF MEDICINAL FOOD
LA English
DT Article
DE children; Mediterranean diet; obesity; physical activity; vitamin D
ID D DEFICIENCY; METABOLIC SYNDROME; OXIDATIVE STRESS; BODY-FAT;
   PREVALENCE; SYSTEM; POPULATION; PREVENTION; ADIPOSITY; CHILDHOOD
AB Vitamin D deficiency is associated with a range of chronic diseases, including childhood obesity. Prevalence of vitamin D deficiency in obese children and adolescents ranges from 6.5% to 57%. This cross-sectional study included 92 obese patients with body mass index z-score >2 and 39 subjects in the control group. Anthropometric and laboratory patient assessment were performed, including the fasting 25-hydroxyvitamin D (25(OH)D). Adherence to the Mediterranean diet was assessed by Mediterranean Diet Quality Index for children and adolescents (KIDMED index), while physical activity was evaluated by Physical Activity Questionnaire (PAQ). Serum levels of 25(OH)D were significantly lower in obese subjects compared to the control group (52.0 +/- 17.93 vs. 64.09 +/- 25.82 nmol/L,P = .003). The subgroup of obese patients with metabolic syndrome (MS) had significantly lower levels of serum vitamin D when compared to the subgroup of obese patients without MS and the control group (46.99 +/- 17.11 vs. 54.58 +/- 17.93 vs. 64.09 +/- 25.82 nmol/L,P = .003). Obese patients with MS had lower PAQ score when compared to obese without MS and the control group (2.32 +/- 0.55 vs. 2.49 +/- 0.67 vs. 2.85 +/- 0.63 nmol/L,P = .002), while no significant differences were observed in the KIDMED index (4.23 +/- 1.81 vs. 4.21 +/- 2.13 vs. 4.87 +/- 2.29,P = .251), respectively. PAQ score was in positive correlation with serum levels of 25(OH)D (r = 0.305,P < .001). This study demonstrated that obese children and adolescents have significantly lower values of serum 25(OH)D. The positive correlation between vitamin D and PAQ score points to the importance of physical activity in the prevention of further cardiovascular complications and MS.
C1 [Simunovic, Marko; Skrabic, Veselin] Univ Hosp Split, Dept Pediat, Spinciceva 1, Split 21000, Croatia.
   [Supe-Domic, Daniela] Univ Hosp Split, Dept Med Lab Diagnost, Split, Croatia.
   [Supe-Domic, Daniela] Univ Split, Dept Hlth Studies, Split, Croatia.
   [Karin, Zeljka] Publ Hlth Inst Split & Dalmatia Cty, Split, Croatia.
   [Degoricija, Marina] Univ Split, Dept Med Chem & Biochem, Sch Med, Split, Croatia.
   [Paradzik, Martina] Univ Hosp Split, Dept Ophthalmol, Split, Croatia.
   [Skrabic, Roko; Jukic, Andrija] Univ Split, Sch Med, Split, Croatia.
   [Bozic, Josko] Univ Split, Sch Med, Dept Pathophysiol, Split, Croatia.
   [Skrabic, Veselin] Univ Split, Sch Med, Dept Pediat, Split, Croatia.
C3 University of Split; University of Split; University of Split;
   University of Split; University of Split; University of Split;
   University of Split; University of Split
RP Simunovic, M (corresponding author), Univ Hosp Split, Dept Pediat, Spinciceva 1, Split 21000, Croatia.
EM markosimunovic@hotmail.com
RI Šupe-Domić, Daniela/Y-3169-2019; Degoricija, Marina/D-5578-2017;
   škrabić, veselin/D-5564-2017; Bozic, Josko/E-1866-2017
OI Skrabic, Veselin/0000-0001-9434-5306; Supe Domic,
   Daniela/0000-0002-5584-3182; Degoricija, Marina/0000-0001-7023-9381;
   Bozic, Josko/0000-0003-1634-0635
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NR 58
TC 8
Z9 8
U1 1
U2 20
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1096-620X
EI 1557-7600
J9 J MED FOOD
JI J. Med. Food
PD APR 1
PY 2021
VL 24
IS 4
BP 385
EP 393
DI 10.1089/jmf.2020.0032
EA AUG 2020
PG 9
WC Chemistry, Medicinal; Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Food Science & Technology; Nutrition &
   Dietetics
GA RN9RQ
UT WOS:000561385800001
PM 32783677
DA 2025-06-11
ER

PT J
AU Gurka, MJ
   Mack, JA
   Chi, XF
   DeBoer, MD
AF Gurka, Matthew J.
   Mack, Jasmine A.
   Chi, Xiaofei
   DeBoer, Mark D.
TI Use of metabolic syndrome severity to assess treatment with vitamin E
   and pioglitazone for non-alcoholic steatohepatitis
SO JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
LA English
DT Article
DE Non-alcoholic fatty liver disease; Non-alcoholic steatohepatitis;
   Oxidative stress; Treatment
ID FATTY LIVER-DISEASE; INSULIN-RESISTANCE; INDEPENDENT ASSOCIATIONS;
   NAFLD; RISK; SEX; MANAGEMENT; PREDICTOR; HISTORY; TESTS
AB Background and Aim Non-alcoholic steatohepatitis (NASH), which can lead to liver failure, requires liver biopsies to follow and is difficult to treat. Our goal was to assess metabolic syndrome (MetS) severity as a predictor of treatment success and a marker of response. Methods We assessed data from the Pioglitazone, Vitamin E, or Placebo for NASH Study, in which individuals with biopsy-confirmed NASH were randomized to receive pioglitazone, vitamin E, or placebo for 96 weeks. We assessed associations of a sex-specific and race/ethnicity-specific MetS severityZ-score (MetS-Z) at baseline and 48 weeks with biopsy-determined endpoint of NASH resolution at 96 weeks. Results Baseline MetS-Z was inversely associated with odds of NASH resolution (odds ratio [OR] per 1 SD of MetS-Z: 0.47, 95% confidence interval [CI] 0.28, 0.79). Decrease in MetS-Z during initial 48-week intervention was greatest for pioglitazone treatment (effect size: -0.31, 95% CI -0.15, -0.48) and for vitamin E tended toward being greater for those withversuswithout NASH resolution (-0.18vs-0.05). Overall, 48-week change in MetS-Z was associated with NASH resolution (OR per 1-SD change: 0.53, 95% CI 0.33, 0.85), although this was attenuated in models that included transaminases, which remained linked to treatment success (OR by change-in-aspartate aminotransferaseZ-score: 0.38, 95% CI 0.19, 0.76). Conclusions Individuals with more severe metabolic derangement at baseline were less likely to exhibit NASH resolution, suggesting that individuals may have a threshold of MetS severity beyond which successful treatment is unlikely. As an integrated marker of metabolic abnormalities, MetS-Z was correlated with successful treatment, although transaminases were a more consistent marker of NASH resolution.
C1 [Gurka, Matthew J.; Mack, Jasmine A.; Chi, Xiaofei] Univ Florida, Coll Med, Dept Hlth Outcomes & Biomed Informat, Gainesville, FL USA.
   [DeBoer, Mark D.] Univ Virginia, Dept Pediat, Div Pediat Endocrinol, POB 800386,409 Lane Rd,Room 2017, Charlottesville, VA 22908 USA.
C3 State University System of Florida; University of Florida; University of
   Virginia
RP DeBoer, MD (corresponding author), Univ Virginia, Dept Pediat, Div Pediat Endocrinol, POB 800386,409 Lane Rd,Room 2017, Charlottesville, VA 22908 USA.
EM deboer@virginia.edu
RI Mack, Jasmine/LYO-4279-2024
OI Mack, Jasmine/0000-0001-7343-0579
FU National Institutes of Health [1R01HL120960]; National Human Genome
   Research Institute [T32HG000040] Funding Source: NIH RePORTER
FX This work was supported by the National Institutes of Health grant
   1R01HL120960 (M. J. G. and M. D. D.).
CR Adams LA, 2009, AM J GASTROENTEROL, V104, P861, DOI 10.1038/ajg.2009.67
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NR 33
TC 9
Z9 9
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0815-9319
EI 1440-1746
J9 J GASTROEN HEPATOL
JI J. Gastroenterol. Hepatol.
PD JAN
PY 2021
VL 36
IS 1
SI SI
BP 249
EP 256
DI 10.1111/jgh.15131
EA JUL 2020
PG 8
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA PS1KE
UT WOS:000545344700001
PM 32506513
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Ding, XQ
   Wu, WY
   Jiao, RQ
   Gu, TT
   Xu, Q
   Pan, Y
   Kong, LD
AF Ding, Xiao-Qing
   Wu, Wen-Yuan
   Jiao, Rui-Qing
   Gu, Ting-Ting
   Xu, Qiang
   Pan, Ying
   Kong, Ling-Dong
TI Curcumin and allopurinol ameliorate fructose-induced hepatic
   inflammation in rats via miR-200a-mediated TXNIP/NLRP3 inflammasome
   inhibition
SO PHARMACOLOGICAL RESEARCH
LA English
DT Article
DE Curcumin; Fructose; Hepatic inflammation; miR-200a; TXNIP/NLRP3
ID THIOREDOXIN-INTERACTING PROTEIN; OXIDATIVE STRESS; NLRP3 INFLAMMASOME;
   DIABETIC-NEPHROPATHY; INSULIN-RESISTANCE; METABOLIC SYNDROME; LIVER;
   ACTIVATION; MICRORNAS; MIR-200A
AB Excess fructose consumption causes high prevalence of metabolic syndrome and inflammatory liver diseases. The aim of the current study was to investigate the therapeutic effects and underlying molecular mechanisms of curcumin and allopurinol in high fructose-induced hepatic inflammation. Male Sprague-Dawley rats were supplied with standard rat chow and drinking water containing 10% (w/v) fructose for consecutive 12 weeks. Curcumin (15, 30 and 60 mg/kg) and allopurinol (5 mg/kg) were administered to rats via oral gavage daily from Week 7 to 12. For in vitro experiments, curcumin (2.5 mu M) and allopurinol (100 mu M) were treated to 5 mM fructose-exposed Buffalo rat liver cell line (BRL-3 A) and human hepatoblastoma cell line (HepG2), respectively. The data from these animal and hepatocyte models showed that curcumin and allopurinol ameliorated fructose induced metabolic symptom, especially hepatic inflammation in rats. Interestingly, down-regulation of microRNA-200a (miR-200a) was screened out in livers of fructose-fed rats and then validated in fructose-exposed BRL-3 A and HepG2 cells. Fructose-induced miR-200a low-expression was identified as a negative mediator of thioredoxin interacting protein (TXNIP) by direct targeting of 3'UTR-rTXNIP, subsequently activating the NOD-like receptor pyrin domain containing 3 (NLRP3) inflammasome in BRL-3 A cells. Curcumin, as well as allopurinol, notably up-regulated miR-200a expression, accordingly, down-regulated TXNIP and inhibited NLRP3 inflammasome activation in fructose-fed rat livers and fructose-exposed BRL-3 A and HepG2 cells. Taken together, this study firstly identified miR-200a as a biomarker of fructose-induced hepatic inflammation, and revealed the hepatoprotection of curcumin and allopurinol via up-regulating miR-200a-mediated TXNIP/NLRP3 inflammasome pathway.
C1 [Ding, Xiao-Qing; Wu, Wen-Yuan; Jiao, Rui-Qing; Gu, Ting-Ting; Xu, Qiang; Pan, Ying; Kong, Ling-Dong] Nanjing Univ, Sch Life Sci, State Key Lab Pharmaceut Biotechnol, Nanjing 210023, Jiangsu, Peoples R China.
C3 Nanjing University
RP Pan, Y; Kong, LD (corresponding author), Nanjing Univ, Sch Life Sci, State Key Lab Pharmaceut Biotechnol, Nanjing 210023, Jiangsu, Peoples R China.
EM pany@nju.edu.cn; kongld@nju.edu.cn
OI Gu, Ting-ting/0000-0002-5416-9659
FU National Natural Science Foundation of China [81573667]; Fundamental
   Research Funds for the Central Universities [020814380021]
FX This project was financially supported by the National Natural Science
   Foundation of China (No. 81573667) and the Fundamental Research Funds
   for the Central Universities (No. 020814380021).
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NR 58
TC 60
Z9 62
U1 3
U2 45
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 1043-6618
EI 1096-1186
J9 PHARMACOL RES
JI Pharmacol. Res.
PD NOV
PY 2018
VL 137
BP 64
EP 75
DI 10.1016/j.phrs.2018.09.021
PG 12
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA HB8QS
UT WOS:000451356100007
PM 30248460
DA 2025-06-11
ER

PT J
AU Ueba, T
   Nomura, S
   Inami, N
   Nishikawa, T
   Kajiwara, M
   Iwata, R
   Yamashita, K
AF Ueba, Tetsuya
   Nomura, Shosaku
   Inami, Norihito
   Nishikawa, Tomofumi
   Kajiwara, Motohiro
   Iwata, Ryoichi
   Yamashita, Kohsuke
TI Plasma Level of Platelet-Derived Microparticles Is Associated with
   Coronary Heart Disease Risk Score in Healthy Men
SO JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
LA English
DT Article
DE Atherothrombosis; Platelet-derived microparticle; Framingham coronary
   heart disease risk score; High sensitivity CRP
ID TRANSIENT ISCHEMIC ATTACKS; REMNANT-LIKE PARTICLE; HIGH-SHEAR-STRESS;
   METABOLIC SYNDROME; ARTERY-DISEASE; ENDOTHELIAL MICROPARTICLES;
   CARDIOVASCULAR-DISEASE; HYPERTENSIVE PATIENTS; ENZYME-IMMUNOASSAY;
   P-SELECTIN
AB Aim: The aim of this study was to clarify the relationship between platelet-derived microparticles (PDMPs) and the Framingham 10-yr coronary heart disease (CHD) risk score.
   Methods: A cross-sectional study of healthy volunteers free of medication, and cardiovascular or cerebrovascular disease was conducted. The subjects were 190 Japanese men (median age 41). An ELISA kit and monoclonal antibodies against CD42b and CD42a (glycoprotein Ib and IX) were used.
   Results: PDMPs are correlated with platelet count, high sensitivity C-reactive protein (hsCRP), and diastolic blood pressure by multivariate analysis (R-2 = 0.316, p < 0.001). Quartile range of PDMPs is significantly associated with the 10-yr CHD risk score after adjusting for age, platelet count, hsCRP, and hypertension (p = 0.033) and for age, platelet count, hsCRP, and presence of metabolic syndrome (MS) (p = 0.020). In individuals with a predicted 10-yr risk for CHD >= 8% (corresponding with the highest quartile), compared to those with a predicted 10-yr risk <8%, the odds ratio (OR), adjusted for age, platelet count, hsCRP, and hypertension, was 3.3 (1.2-8.9) and adjusted for age, platelet count, hsCRP, and MS, was 4.5 (1.6-11.8). The age-, platelet count-, hsCRP- and hypertension-adjusted OR for a 10-yr CHD risk score >= 8% was 0.8 (0.5-1.3) for hsCRP and 3.9 (1.6-9.4) for hypertension. The age-, platelet count-, hsCRP- and MS -adjusted OR for a 10-yr CHD risk score >= 8% was 0.7 (0.4-1.2) for hsCRP and 7.9 (2.6-24.5) for MS.
   Conclusion: Elevated PDMPs are associated with the 10-yr CHD risk score in healthy men.
C1 [Ueba, Tetsuya; Nishikawa, Tomofumi; Kajiwara, Motohiro; Iwata, Ryoichi; Yamashita, Kohsuke] Kishiwada City Hosp, Dept Neurosurg, Osaka, Japan.
   [Nomura, Shosaku] Kishiwada City Hosp, Dept Hematol, Osaka, Japan.
   [Inami, Norihito] Kansai Med Univ, Dept Internal Med 2, Osaka, Japan.
C3 Kansai Medical University
RP Ueba, T (corresponding author), Kishiwada City Hosp, Dept Neurosurg, 1001 Gakuharachou, Kishiwada 5968501, Japan.
EM tueba@kuhp.kyoto-u.ac.jp
RI Ueba, Tetsuya/AFL-6434-2022; Iwata, Ryoichi/AAL-6698-2020
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NR 48
TC 50
Z9 53
U1 0
U2 5
PU JAPAN ATHEROSCLEROSIS SOC
PI TOKYO
PA NICHINAI-KAIKAN B1, 3-28-8 HONGO BUNKYO-KU, TOKYO, 113-0033, JAPAN
SN 1340-3478
EI 1880-3873
J9 J ATHEROSCLER THROMB
JI J. Atheroscler. Thromb.
PY 2010
VL 17
IS 4
BP 342
EP 349
DI 10.5551/jat.2964
PG 8
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 606EV
UT WOS:000278406000003
PM 20379056
OA hybrid
DA 2025-06-11
ER

PT J
AU Moran, A
   Jacobs, DR
   Steinberger, J
   Steffen, LM
   Pankow, JS
   Hong, CP
   Sinaiko, AR
AF Moran, Antoinette
   Jacobs, David R., Jr.
   Steinberger, Julia
   Steffen, Lyn M.
   Pankow, James S.
   Hong, Ching-Ping
   Sinaiko, Alan R.
TI Changes in insulin resistance and cardiovascular risk during
   adolescence: Establishment of differential risk in males and females
SO CIRCULATION
LA English
DT Article
DE insulin resistance; risk factors; youth; sex; metabolic syndrome
ID METABOLIC SYNDROME PHENOTYPE; POSTMENOPAUSAL WOMEN; BLOOD-PRESSURE;
   REPLACEMENT THERAPY; OXIDATIVE STRESS; BODY FATNESS; ESTROGEN;
   TESTOSTERONE; SENSITIVITY; CHILDREN
AB Background - Developmental changes in insulin resistance and cardiovascular risk were studied in youths 11 to 19 years of age.
   Methods and Results - A cohort was randomly selected after blood pressure screening of Minneapolis, Minn, school children. Studies were done 3 times on this cohort and once on their siblings ( 996 observations on 507 individuals from 363 families). Insulin sensitivity was determined by euglycemic clamp. Body mass index and waist circumference increased similarly in both sexes from ages 11 to 19 years. Body fat decreased in males and increased in females ( P < 0.001). Lean body mass increased at a steeper rate in males ( P < 0.0001). Insulin resistance was lower in males at 11 years but increased steadily to 19 years ( P = 0.003); in contrast, it did not increase in females. Thus, despite being less insulin resistant at 11 years and decreasing in fatness during puberty, males became more insulin resistant than females by 19 years of age. Triglycerides increased in males and high- density lipoprotein cholesterol decreased, whereas the opposite pattern was seen in females, which resulted in higher triglycerides and lower high- density lipoprotein cholesterol in males at 19 years. No gender difference in low- density lipoprotein or total cholesterol was seen. Systolic blood pressure increased in both sexes but at a greater rate in boys ( P = 0.03).
   Conclusions - During the transition from late childhood through adolescence, insulin resistance in males increased in association with increased triglycerides and decreased high- density lipoprotein cholesterol, despite a concurrent reduction in body fatness, whereas the opposite occurred in females. These gender- related developmental changes in insulin resistance, which were independent from changes in fatness, total cholesterol, and low- density lipoprotein cholesterol, are consistent with an early role for insulin resistance in the increased cardiovascular risk found in males.
C1 [Moran, Antoinette; Steinberger, Julia; Sinaiko, Alan R.] Univ Minnesota, Dept Pediat, Minneapolis, MN 55454 USA.
   [Jacobs, David R., Jr.; Steffen, Lyn M.; Pankow, James S.; Hong, Ching-Ping; Sinaiko, Alan R.] Univ Minnesota, Sch Publ Hlth, Minneapolis, MN USA.
   [Jacobs, David R., Jr.] Univ Oslo, Dept Nutr, Oslo, Norway.
C3 University of Minnesota System; University of Minnesota Twin Cities;
   University of Minnesota System; University of Minnesota Twin Cities;
   University of Oslo
RP Moran, A (corresponding author), Univ Minnesota, Dept Pediat, MMC 404,516 Delaware St SE, Minneapolis, MN 55454 USA.
EM moran001@umn.edu
RI Jacobs, David/G-5405-2011
OI Pankow, James/0000-0001-7076-483X; Steinberger,
   Julia/0000-0002-2892-8594; Steffen, Lyn M/0000-0002-4053-6729; Jacobs,
   David/0000-0002-7232-0543
FU NCRR NIH HHS [M01-RR-00400] Funding Source: Medline; NHLBI NIH HHS
   [HL-52851] Funding Source: Medline
CR [Anonymous], PEDIATRICS 2
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NR 46
TC 172
Z9 186
U1 0
U2 7
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0009-7322
EI 1524-4539
J9 CIRCULATION
JI Circulation
PD MAY 6
PY 2008
VL 117
IS 18
BP 2361
EP 2368
DI 10.1161/CIRCULATIONAHA.107.704569
PG 8
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 297BA
UT WOS:000255589300007
PM 18427135
DA 2025-06-11
ER

PT J
AU Meephat, S
   Prasatthong, P
   Rattanakanokchai, S
   Bunbupha, S
   Maneesai, P
   Pakdeechote, P
AF Meephat, Sariya
   Prasatthong, Patoomporn
   Rattanakanokchai, Siwayu
   Bunbupha, Sarawoot
   Maneesai, Putcharawipa
   Pakdeechote, Poungrat
TI Diosmetin attenuates metabolic syndrome and left ventricular alterations
   via the suppression of angiotensin II/AT1
   receptor/gp<SUP>91phox</SUP>/p-NF-κB protein expression in high-fat diet
   fed rats
SO FOOD & FUNCTION
LA English
DT Article
ID CORONARY-HEART-DISEASE; NF-KAPPA-B; INSULIN-RESISTANCE; OXIDATIVE
   STRESS; ASIATIC ACID; METFORMIN; SYSTEM; ACTIVATION; HYPERTROPHY;
   MECHANISMS
AB Diosmetin, a monomethoxyflavone, is isolated from citrus fruits. The objective of this research was to test the biological role of diosmetin on parameters of metabolic syndrome (MS) and left ventricular (LV) alterations in rats fed with a high-fat (HF) diet. MS was induced by feeding male Sprague-Dawley rats with a HF diet plus 15% fructose in drinking water for 16 weeks. MS rats were given diosmetin (20 or 40 mg per kg per day) or metformin (100 mg per kg per day) for the final four weeks. Diosmetin attenuated signs of MS including, hypertension, hyperglycemia, insulin resistance, and dyslipidemia in rats that received the HF diet (p < 0.05). A decreased stroke volume, ejection fraction, fractional shortening, LV hypertrophy and fibrosis present in the MS group were alleviated by diosmetin treatment (p < 0.05). Diosmetin also suppressed angiotensin-converting enzyme activity, plasma angiotensin II (Ang II) levels and angiotensin II type 1 (AT1) receptor protein expression in MS rats. Increases in superoxide (O-2(-)) formation, plasma malondialdehyde, plasma nitrate and nitrite and gp(91phox) expression induced by a HF diet were ameliorated in the diosmetin treated group. Inflammation indicated by an increased phospho nuclear factor kappa B (p-NF-kappa B) protein expression and cardiac TNF-alpha concentration was reduced in MS rats receiving diosmetin (p < 0.05). Metformin also attenuated MS, cardiac abnormalities relevant to decreasing the renin-angiotensin system stimulation, reactive oxygen species and inflammation in MS rats (p < 0.05). Diosmetin alleviated MS and LV dysfunction and remodeling in HF diet-induced MS rats. These results could be associated with the suppression of the Ang II/AT1 receptor/gp(91phox)/p-NF-kappa B protein pathway.
C1 [Meephat, Sariya; Prasatthong, Patoomporn; Maneesai, Putcharawipa; Pakdeechote, Poungrat] Khon Kaen Univ, Fac Med, Dept Physiol, Khon Kaen 40002, Thailand.
   [Rattanakanokchai, Siwayu] Khon Kaen Univ, Fac Vet Med, Khon Kaen 40002, Thailand.
   [Bunbupha, Sarawoot] Mahasarakham Univ, Fac Med, Maha Sarakham 44000, Thailand.
   [Pakdeechote, Poungrat] Khon Kaen Univ, Res Inst Human High Performance & Hlth Promot, Khon Kaen 40002, Thailand.
C3 Khon Kaen University; Khon Kaen University; Mahasarakham University;
   Khon Kaen University
RP Pakdeechote, P (corresponding author), Khon Kaen Univ, Fac Med, Dept Physiol, Khon Kaen 40002, Thailand.; Pakdeechote, P (corresponding author), Khon Kaen Univ, Res Inst Human High Performance & Hlth Promot, Khon Kaen 40002, Thailand.
EM sari.meephat@gmail.com; patoomporn94@gmail.com; siwayu612@gmail.com;
   sarawoot.b@msu.ac.th; putcma@kku.ac.th; ppoung@kku.ac.th
RI Maneesai, Putcharawipa/AAK-4258-2021
FU Khon Kaen University, Khon Kaen, Thailand [IN63117, RP64]; Faculty of
   Medicine, Khon Kaen University, Khon Kaen, Thailand; Research Institute
   for Human High Performance and Health Promotion, Khon Kaen University,
   Khon Kaen, Thailand
FX This study was supported by grants from Invitation Research Fund
   (IN63117), Faculty of Medicine, Research Program (RP64), Research and
   Graduate Studies, and Research Institute for Human High Performance and
   Health Promotion, Khon Kaen University, Khon Kaen, Thailand. We would
   like to acknowledge Professor James A. Will for editing the MS via
   Publication Clinic KKU, Thailand.
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NR 64
TC 20
Z9 21
U1 2
U2 10
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PD FEB 21
PY 2021
VL 12
IS 4
BP 1469
EP 1481
DI 10.1039/d0fo02744h
PG 13
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA QP6PH
UT WOS:000623956200007
PM 33449987
DA 2025-06-11
ER

PT J
AU Wattanathorn, J
   Palachai, N
   Thukham-mee, W
   Muchimapura, S
AF Wattanathorn, Jintanaporn
   Palachai, Nut
   Thukham-mee, Wipawee
   Muchimapura, Supaporn
TI y Memory-Enhancing Effect of a Phytosome Containing the Combined Extract
   of Mulberry Fruit and Ginger in an Animal Model of Ischemic Stroke with
   Metabolic Syndrome
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Article
ID BRAIN; ASSAY
AB The prevalence of dementia following cerebral ischemia in metabolic syndrome (MetS) condition is increasing, and most of the cases are often severe. Unfortunately, no effective strategy for treating this condition is available. Based on the positive modulation effect of a polyphenol-rich substance on dementia and the improvement in bioavailability and stability of polyphenols induced by the phytosome technique together with the use of the synergistic concept, we hypothesized that a phytosome containing the combined extract of mulberry fruit and ginger (PMG) should mitigate dementia and memory impairment following ischemic stroke in MetS. MetS was induced in male Wistar rats weighing 180-200 g by exposure to a 16-week feeding period of high-carbohydrate high-fat (HCHF) diet. MetS rats were orally given PMG at doses of 50, 100, and 200 mg-kg(-1) BW 21 days before and 21 days after the occlusion of the right middle cerebral artery (Rt. MCAO). Then, their spatial memory was determined and the possible underlying mechanisms explored via the alterations of acetylcholinesterase (AChE), neuron density, malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), interleukin-6 (IL-6), and signal transduction via extracellular signal-regulated kinase (ERK) pathway in both the cerebral cortex and the hippocampus. It was found that PMG significantly enhanced memory. It also decreased AChE, IL-6, and MDA but increased SOD, CAT, GSH-Px, neuron density, and phosphorylation of ERK. These data suggested the cognitive enhancing effect of PMG. The possible underlying mechanisms might occur partly via the improvement of cholinergic function via the ERK pathway together with the decrease in neurodegeneration induced by the reduction of oxidative stress and inflammation. However, a subchronic toxicity study is also required to assure the safety of PMG consumption before moving forward to a clinical trial study.
C1 [Wattanathorn, Jintanaporn; Thukham-mee, Wipawee; Muchimapura, Supaporn] Khon Kaen Univ, Dept Physiol, Fac Med, Khon Kaen 40002, Thailand.
   [Wattanathorn, Jintanaporn; Palachai, Nut; Thukham-mee, Wipawee; Muchimapura, Supaporn] Khon Kaen Univ, Integrat Complementary Alternat Med Res, Khon Kaen 40002, Thailand.
   [Wattanathorn, Jintanaporn; Palachai, Nut; Thukham-mee, Wipawee; Muchimapura, Supaporn] Khon Kaen Univ, Res Inst Human High Performance & Hlth Promot, Khon Kaen 40002, Thailand.
   [Palachai, Nut] Khon Kaen Univ, Dept Physiol, Khon Kaen 40002, Thailand.
   [Palachai, Nut] Khon Kaen Univ, Grad Sch, Neurosci Program, Fac Med, Khon Kaen 40002, Thailand.
C3 Khon Kaen University; Khon Kaen University; Khon Kaen University; Khon
   Kaen University; Khon Kaen University
RP Wattanathorn, J (corresponding author), Khon Kaen Univ, Dept Physiol, Fac Med, Khon Kaen 40002, Thailand.; Wattanathorn, J (corresponding author), Khon Kaen Univ, Integrat Complementary Alternat Med Res, Khon Kaen 40002, Thailand.; Wattanathorn, J (corresponding author), Khon Kaen Univ, Res Inst Human High Performance & Hlth Promot, Khon Kaen 40002, Thailand.
EM jinwat05@gmail.com; nuttpalachai@gmail.com; meewep@gmail.com;
   supmuc@kku.ac.th
RI Palachai, Nut/HKM-6781-2023
OI Palachai, Nut/0000-0002-9672-9941; Wattanathorn,
   Jintanaporn/0000-0002-7383-2348; Thukhammee,
   Wipawee/0000-0001-6923-396X; Muchimapura, Supaporn/0000-0001-7756-1955
FU Royal Golden Jubilee (RGJ) Ph.D. Programme, Thailand Research Fund (TRF)
   [Ph.D./0181/2558]; Integrative Complementary Alternative Medicine
   Research Center in the Research Institute for Human High Performance and
   Health Promotion, Khon Kaen University, Khon Kaen, Thailand
FX This study was supported by the Royal Golden Jubilee (RGJ) Ph.D.
   Programme, which is a part of the Thailand Research Fund (TRF) (Research
   No. Ph.D./0181/2558), and by the Integrative Complementary Alternative
   Medicine Research Center in the Research Institute for Human High
   Performance and Health Promotion, Khon Kaen University, Khon Kaen,
   Thailand.
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NR 38
TC 24
Z9 24
U1 0
U2 9
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PD JUL 29
PY 2020
VL 2020
AR 3096826
DI 10.1155/2020/3096826
PG 19
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA NC7GW
UT WOS:000561384700002
PM 32802263
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Brennan, KM
   Kroener, LL
   Chazenbalk, GD
   Dumesic, DA
AF Brennan, Kathleen M.
   Kroener, Lindsay L.
   Chazenbalk, Gregorio D.
   Dumesic, Daniel A.
TI Polycystic Ovary Syndrome: Impact of Lipotoxicity on Metabolic and
   Reproductive Health
SO OBSTETRICAL & GYNECOLOGICAL SURVEY
LA English
DT Article
ID BODY-MASS INDEX; INSULIN-RESISTANCE; OBESE WOMEN; WEIGHT-LOSS; FAT
   DISTRIBUTION; SYNDROME PCOS; ENDOPLASMIC-RETICULUM; ANDROGEN EXCESS;
   ADIPOSE-TISSUE; TASK-FORCE
AB Importance Polycystic ovary syndrome (PCOS) is the most common endocrinopathy of reproductive-aged women. Women with PCOS are at increased risk of developing several metabolic and reproductive abnormalities, including metabolic syndrome. Underlying the combined metabolic and reproductive dysfunction is lipotoxicity, defined as the ectopic deposition of lipid in nonadipose tissue where it induces oxidative stress linked with insulin resistance and inflammation. Objective To examine what metabolic components underlie insulin resistance in PCOS, how lipotoxicity through insulin resistance impairs metabolism and reproduction in these women, and why evidence-based, individualized management is essential for their care. Evidence Acquisition PubMed search was performed using relevant terms to identify journal articles related to the subject. Relevant textbook chapters were also used. Results Polycystic ovary syndrome by Rotterdam criteria represents a complex syndrome of heterogeneous expression with variable adverse metabolic and reproductive implications. Women with classic PCOS are often insulin resistant and at greatest risk of developing metabolic syndrome with preferential fat accumulation and weight gain. Moreover, PCOS women may also have an altered capacity to properly store fat, causing ectopic lipid accumulation in nonadipose tissue, including the ovaries, where it can perpetuate insulin resistance and inflammation and harm the oocyte. Conclusions and Relevance A personalized approach to managing PCOS is essential to improve the health of all PCOS women through cost-effective prevention and/or treatment, to minimize the risk of pregnancy complications in those individuals wishing to conceive, and to optimize the long-term health of PCOS women and their offspring. Target Audience Obstetricians and gynecologists, family physicians Learning Objectives After completing this activity, the learner should be better able to explain the phenotypic variants of PCOS; describe how obesity, preferential abdominal fat accumulation, and lipotoxicity adversely affect the health of PCOS women; and propose a preconception management plan for overweight and obese PCOS women wishing to conceive.
C1 [Brennan, Kathleen M.; Kroener, Lindsay L.; Chazenbalk, Gregorio D.; Dumesic, Daniel A.] Univ Calif Los Angeles, Dept Obstet & Gynecol, Div Reprod Endocrinol & Infertil, Los Angeles, CA 90024 USA.
C3 University of California System; University of California Los Angeles
RP Dumesic, DA (corresponding author), Univ Calif Los Angeles, David Geffen Sch Med, Dept Obstet & Gynecol, 10833 Le Conte Ave,Room 27-139 CHS, Los Angeles, CA 90095 USA.
EM DDumesic@mednet.ucla.edu
OI Dumesic, Daniel/0000-0003-0387-1277
FU Eunice Kennedy Shriver National Institute of Child Health & Human
   Development, National Institutes of Health (NIH) through the Oregon
   National Primate Research Center [P50HD071836]
FX This study was funded in part by a grant from the Eunice Kennedy Shriver
   National Institute of Child Health & Human Development, National
   Institutes of Health (NIH), under award P50HD071836 through the Oregon
   National Primate Research Center. The content is solely the
   responsibility of the authors and does not necessarily represent the
   official views of the NIH.
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NR 100
TC 20
Z9 22
U1 1
U2 15
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0029-7828
EI 1533-9866
J9 OBSTET GYNECOL SURV
JI Obstet. Gynecol. Surv.
PD APR
PY 2019
VL 74
IS 4
BP 223
EP 231
DI 10.1097/OGX.0000000000000661
PG 9
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA HU1AE
UT WOS:000465003000018
PM 31344250
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Ramos, JS
   Dalleck, LC
   Ramos, MV
   Borrani, F
   Roberts, L
   Gomersall, S
   Beetham, KS
   Dias, KA
   Keating, SE
   Fassett, RG
   Sharman, JE
   Coombes, JS
AF Ramos, Joyce S.
   Dalleck, Lance C.
   Ramos, Maximiano V.
   Borrani, Fabio
   Roberts, Llion
   Gomersall, Sjaan
   Beetham, Kassia S.
   Dias, Katrin A.
   Keating, Shelley E.
   Fassett, Robert G.
   Sharman, James E.
   Coombes, Jeff S.
TI 12min/week of high-intensity interval training reduces aortic reservoir
   pressure in individuals with metabolic syndrome: a randomized trial
SO JOURNAL OF HYPERTENSION
LA English
DT Article
DE aorta; interval training; vascular function
ID ALL-CAUSE MORTALITY; CARDIOVASCULAR EVENTS; BLOOD-PRESSURE; ARTERIAL
   STIFFNESS; OXIDATIVE STRESS; CARDIOMETABOLIC DISEASE; MODERATE EXERCISE;
   VASCULAR FUNCTION; EXCESS PRESSURE; RISK-FACTORS
AB Objective:Decreased aortic reservoir function leads to a rise in aortic reservoir pressure that is an independent predictor of cardiovascular events. Although there is evidence that high-intensity interval training (HIIT) would be useful to improve aortic reservoir pressure, the optimal dose of high-intensity exercise to improve aortic reservoir function has yet to be investigated. Therefore, this study compared the effect of different volumes of HIIT and moderate-intensity continuous training (MICT) on aortic reservoir pressure in participants with the metabolic syndrome (MetS).Methods:Fifty individuals with MetS were randomized into one of the following 16-week training programs: MICT [n=17, 30min at 60-70% peak heart rate (HRpeak), five times/week]; 4x4-min high-intensity interval training (4HIIT) (n=15, 4x4min bouts at 85-95% HRpeak, interspersed with 3min of active recovery at 50-70% HRpeak, three times/week); and 1x4-min high-intensity interval training (1HIIT) (n=18, 1x4min bout at 85-95% HRpeak, three times/week). Aortic reservoir pressure was calculated from radial applanation tonometry.Results:Although not statistically significant, there was a trend for a small-to-medium group x time interaction effect on aortic reservoir pressure, indicating a positive adaptation following 1HIIT compared with 4HIIT and MICT [F (2,46)=2.9, P=0.07, (2)=0.06]. This is supported by our within-group analysis wherein only 1HIIT significantly decreased aortic reservoir pressure from pre to postintervention (pre-post: 1HIIT 3316 to 31 +/- 13, P=0.03; MICT 29 +/- 9-28 +/- 8, P=0.78; 4HIIT 28 +/- 10-30 +/- 9mmHg, P=0.10).Conclusion:Three sessions of 4min of high-intensity exercise per week (12min/week) was sufficient to improve aortic reservoir pressure, and thus may be a time-efficient exercise modality for reducing cardiovascular risk in individuals with MetS.
C1 [Ramos, Joyce S.; Roberts, Llion; Gomersall, Sjaan; Beetham, Kassia S.; Dias, Katrin A.; Keating, Shelley E.; Fassett, Robert G.; Coombes, Jeff S.] Univ Queensland, Sch Human Movement & Nutr Sci, Ctr Res Exercise Phys Act & Hlth, St Lucia, Qld, Australia.
   [Dalleck, Lance C.] Western State Colorado Univ, Dept Recreat Exercise & Sport Sci, Gunnison, CO USA.
   [Ramos, Maximiano V.] Auckland Univ Technol, Sch Engn, Inst Biomed Technol, Auckland, New Zealand.
   [Borrani, Fabio] ISSUL, Lausanne, Switzerland.
   [Borrani, Fabio] Univ Lausanne, Fac Biol & Med, Dept Physiol, Lausanne, Switzerland.
   [Sharman, James E.] Univ Tasmania, Menzies Inst Med Res, Hobart, Tas, Australia.
C3 University of Queensland; Auckland University of Technology; University
   of Lausanne; University of Tasmania; Menzies Institute for Medical
   Research
RP Ramos, JS (corresponding author), Univ Queensland, Sch Human Movement & Nutr Sci, Ctr Res Exercise Phys Act & Hlth, St Lucia, Qld, Australia.; Coombes, JS (corresponding author), Univ Queensland, Room 535,HMS Bldg 26B, St Lucia, Qld 4072, Australia.
EM mary.ramos@uq.net.au; jcoombes@uq.edu.au
RI Roberts, Llion/AAF-9393-2020; Fassett, Robert/R-3495-2019; Coombes,
   Jeff/F-1764-2010; Sharman, James/B-2755-2009; Keating,
   Shelley/P-2520-2015; Gomersall, Sjaan/J-9665-2013; Roberts,
   Llion/E-6593-2012
OI Coombes, Jeff/0000-0002-6990-3596; Sharman, James/0000-0003-2792-0811;
   Beetham, Kassia/0000-0003-4657-7668; Keating,
   Shelley/0000-0001-5357-2721; Gomersall, Sjaan/0000-0001-6808-0180;
   Ramos, Joyce/0000-0001-8693-6800; Roberts, Llion/0000-0002-2284-1033
FU Norwegian University of Science and Technology; Coca-Cola Company;
   'Australian National Health and Medical Research Council Program Grant'
   at the University of Queensland [569940]
FX Funding for this study was provided by the Norwegian University of
   Science and Technology and from an unrestricted research grant from The
   Coca-Cola Company. S.G. was supported by an 'Australian National Health
   and Medical Research Council Program Grant (#569940)' at the University
   of Queensland.
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NR 55
TC 23
Z9 25
U1 0
U2 16
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0263-6352
EI 1473-5598
J9 J HYPERTENS
JI J. Hypertens.
PD OCT
PY 2016
VL 34
IS 10
BP 1977
EP 1987
DI 10.1097/HJH.0000000000001034
PG 11
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA DX0DU
UT WOS:000384032800009
PM 27467767
DA 2025-06-11
ER

PT J
AU Staiano, AE
   Katzmarzyk, PT
AF Staiano, A. E.
   Katzmarzyk, P. T.
TI Ethnic and sex differences in body fat and visceral and subcutaneous
   adiposity in children and adolescents
SO INTERNATIONAL JOURNAL OF OBESITY
LA English
DT Review
DE pediatric; body fat; visceral adipose tissue; subcutaneous adipose
   tissue; ethnic differences; sex differences
ID CARDIOVASCULAR RISK-FACTORS; AFRICAN-AMERICAN; ABDOMINAL FAT;
   INTRAABDOMINAL FAT; METABOLIC SYNDROME; MASS INDEX; TISSUE DISTRIBUTION;
   GENDER-DIFFERENCES; WHITE ADOLESCENTS; PHYSICAL-ACTIVITY
AB Body fat and the specific depot where adipose tissue (AT) is stored can contribute to cardiometabolic health risks in children and adolescents. Imaging procedures including magnetic resonance imaging and computed tomography allow for the exploration of individual and group differences in pediatric adiposity. This review examines the variation in pediatric total body fat (TBF), visceral AT (VAT) and subcutaneous AT (SAT) due to age, sex, maturational status and ethnicity. TBF, VAT and SAT typically increase as a child ages, though different trends emerge. Girls tend to accumulate more TBF and SAT during and after puberty, depositing fat preferentially in the gynoid and extremity regions. In contrast, pubertal and postpubertal boys tend to deposit more fat in the abdominal region, particularly in the VAT depot. Sexual maturation significantly influences TBF, VAT and SAT. Ethnic differences in TBF are mixed. VAT tends to be higher in white and Hispanic youth, whereas SAT is typically higher in African American youth. Asian youth typically have less gynoid fat but more VAT than whites. Obesity per se may attenuate sex and ethnic differences. Particular health risks are associated with high amounts of TBF, VAT and SAT, including insulin resistance, hepatic steatosis, metabolic syndrome and hypertension. These risks are affected by genetic, biological and lifestyle factors including physical activity, nutrition and stress. Synthesizing evidence is difficult as there is no consistent methodology or definition to estimate and define depot-specific adiposity, and many analyses compare SAT and VAT without controlling for TBF. Future research should include longitudinal examinations of adiposity changes over time in representative samples of youth to make generalizations to the entire pediatric population and examine variation in organ-specific body fat.
C1 [Staiano, A. E.; Katzmarzyk, P. T.] Pennington Biomed Res Ctr, Baton Rouge, LA 70808 USA.
C3 Louisiana State University System; Louisiana State University;
   Pennington Biomedical Research Center
RP Katzmarzyk, PT (corresponding author), Pennington Biomed Res Ctr, 6400 Perkins Rd, Baton Rouge, LA 70808 USA.
EM Peter.Katzmarzyk@pbrc.edu
RI Staiano, Amanda/H-3956-2017; Katzmarzyk, Peter/N-1974-2017
OI Staiano, Amanda/0000-0001-7846-046X; Katzmarzyk,
   Peter/0000-0002-9280-6022
FU Louisiana Public Facilities Authority Endowed Chair in Nutrition; NIH
   National Research Service Award
FX PTK is supported, in part, by the Louisiana Public Facilities Authority
   Endowed Chair in Nutrition. AES is funded, in part, by an NIH National
   Research Service Award.
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NR 90
TC 133
Z9 148
U1 0
U2 24
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0307-0565
EI 1476-5497
J9 INT J OBESITY
JI Int. J. Obes.
PD OCT
PY 2012
VL 36
IS 10
BP 1261
EP 1269
DI 10.1038/ijo.2012.95
PG 9
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 018GX
UT WOS:000309649400002
PM 22710928
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Roberts, CK
   Ng, C
   Hama, S
   Eliseo, AJ
   Barnard, RJ
AF Roberts, Christian K.
   Ng, Carey
   Hama, Susan
   Eliseo, Anna Jane
   Barnard, R. James
TI Effect of a short-term diet and exercise intervention on
   inflammatory/antiinflammatory properties of HDL in overweight/obese men
   with cardiovascular risk factors
SO JOURNAL OF APPLIED PHYSIOLOGY
LA English
DT Article
DE atherosclerosis; lipids; apolipoprotein A-I; paraoxonase;
   platelet-activating factor acetylhydrolase; high-density lipoprotein
ID HIGH-DENSITY-LIPOPROTEIN; CORONARY-HEART-DISEASE;
   ACTIVATING-FACTOR-ACETYLHYDROLASE; MONOCYTE CHEMOTACTIC ACTIVITY;
   CHOLESTEROL LEVELS; BIOLOGICAL-ACTIVITY; METABOLIC SYNDROME; OXIDATIVE
   STRESS; INHIBITS 3; INFLAMMATION
AB There is significant debate regarding high-density lipoprotein cholesterol (HDL-C) and high-fiber. low-fat diets. The present study was designed to examine the effects of lifestyle modification on the inflammatory/anti-inflammatory properties of HDL in obese men (n = 22) with metabolic syndrome factors. Subjects were placed on a high-fiber, low-fat diet in a 3-wk residential program where food was provided ad libitum and daily aerobic exercise was performed. Fasting blood was drawn pre- and postintervention for serum lipids, lipid hydroperoxides, and the ability of subject HDL to alter low-density lipoprotein (LDL)-induced monocyte chemotactic activity (MCA) in a human artery wall coculture. Induction of MCA by control LDL in the absence of HDL was normalized to 1.0. Values > 1.0 after HDL addition indicated proinflammatory HDL: values < 1.0 indicated anti-inflammatory HDL. In addition, proteins involved in regulating HDL function, apolipoprotein A-I (apoA-I), paraoxonase I and 3, and platelet-activating factor acetylhydrolase were measured. After 3 wk, decreases in total-cholesterol, LDL-cholesterol, HDL-C, triglycerides, total cholesterol-to-HDL cholesterol ratio, and lipid hydroperoxides (all P < 0.05) were noted. The HDL inflammatory index decreased (P < 0.05) from pro(14 +/- 0.11) to anti-inflammtory (0.94 +/- 0.09). ApoA-I level and paraoxonase activity did not change; however, platelet-activating factor acetylhydrolase activity increased (P < 0.05). Despite a quantitative reduction in HDL-C, HDL converted from pro- to antiinflammatory),. These data indicate that intensive lifestyle modification improves the function of HDL even in the face of reduced levels, suggesting increased turnover of proinflammatory HDL.
C1 Univ Calif Los Angeles, Dept Physiol Sci, Los Angeles, CA 90095 USA.
   Univ Calif Los Angeles, Atherosclerosis Res Unit, Los Angeles, CA 90095 USA.
C3 University of California System; University of California Los Angeles;
   University of California System; University of California Los Angeles
RP Roberts, CK (corresponding author), Univ Calif Los Angeles, Dept Physiol Sci, 4101 Life Sci Bldg,621 Charles E Young Dr S, Los Angeles, CA 90095 USA.
EM croberts@ucla.edu
FU NHLBI NIH HHS [F32 HL-68406-01] Funding Source: Medline
CR [Anonymous], 1980, 7 COUNTRIES MULTIVAR
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NR 46
TC 144
Z9 163
U1 0
U2 9
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 8750-7587
EI 1522-1601
J9 J APPL PHYSIOL
JI J. Appl. Physiol.
PD DEC
PY 2006
VL 101
IS 6
BP 1727
EP 1732
DI 10.1152/japplphysiol.00345.2006
PG 6
WC Physiology; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology; Sport Sciences
GA 112PF
UT WOS:000242537900026
PM 16902063
DA 2025-06-11
ER

PT J
AU Picasso, MC
   Lo-Tayraco, JA
   Ramos-Villanueva, JM
   Pasupuleti, V
   Hernandez, AV
AF Picasso, Maria C.
   Lo-Tayraco, Jessica A.
   Ramos-Villanueva, Juselly M.
   Pasupuleti, Vinay
   Hernandez, Adrian V.
TI Effect of vegetarian diets on the presentation of metabolic syndrome or
   its components: A systematic review and meta-analysis
SO CLINICAL NUTRITION
LA English
DT Review
DE Vegetarian diets; Metabolic syndrome; Blood pressure; Glucose; Waist
   circumference; Blood lipids
ID ISCHEMIC-HEART-DISEASE; LONG-TERM VEGETARIANS; BLOOD-PRESSURE; LIPID
   PROFILE; CARDIOVASCULAR RISK; PLASMA-LIPIDS; TAIWANESE VEGETARIANS;
   PROTECTIVE FACTOR; BUDDHIST PRIESTS; OXIDATIVE STRESS
AB Background & aims: Several studies have examined the effect of vegetarian diets (VD) on metabolic syndrome (MetS) or its components, but findings have been inconsistent. The aim of this study was to perform a systematic review and meta-analysis of randomized controlled trials (RCTs) and observational studies to assess the association between VD and MetS or its components (systolic blood pressure [SBP], diastolic blood pressure [DBP], fasting glucose triglycerides, waist circumference [WC], HDL-cholesterol (HDL-C)) in adults.
   Methods: The Cochrane Library, EMBASE, PubMed, Web of Science, and Scopus were searched. RCTs, cohort studies and cross-sectional studies evaluating the effects of VD on MetS or its components in adults, with omnivore diet as control group, were included. Random effects meta-analyses stratified by study design were employed to calculate pooled estimates.
   Results: A total of 71 studies (n = 103 008) met the inclusion criteria (6 RCTs, 2 cohorts, 63 cross-sectional). VD were not associated with MetS in comparison to omnivorous diet (OR 0.96, 95% CI 0.50 -1.85, p = 0.9) according to meta-analysis of five cross-sectional studies. Likewise, meta-analysis of RCTs and cohort studies indicated that consumption of VD were not associated with MetS components. Meta analysis of cross-sectional studies demonstrated that VD were significantly associated with lower levels of SBP (mean difference [MD] -4.18 mmHg, 95%CI -5.57 to -2.80, p < 0.00001), DBP (MD -3.03 mmHg, 95% CI -4.93 to -1.13, p = 0.002), fasting glucose (MD -0.26 mmol/L, 95% CI -0.35 to -0.17, p < 0.00001), WC (MD -1.63 cm, 95% CI -3.13 to -0.13, p = 0.03), and HDL-C (MD -0.05 mmol/L, 95% CI -0.07 to -0.03, p < 0.0001) in comparison to omnivorous diet. Heterogeneity of effects among cross-sectional studies was high. About, one-half of the included studies had high risk of bias.
   Conclusions: VD in comparison with omnivorous diet is not associated with a lower risk of MetS based on results of meta-analysis of cross-sectional studies. The association between VD and lower levels of SBP, DBP, HDL-C, and fasting glucose is uncertain due to high heterogeneity across the cross-sectional studies. Larger and controlled studies are needed to evaluate the association between VD and MetS and its components. (C) 2018 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.
C1 [Picasso, Maria C.; Lo-Tayraco, Jessica A.; Ramos-Villanueva, Juselly M.] Univ Peruana Ciencias Aplicadas UPC, Fac Hlth Sci, Sch Nutr, Lima, Peru.
   [Pasupuleti, Vinay] ProEd Commun Inc, Cleveland, OH 44122 USA.
   [Hernandez, Adrian V.] Univ Peruana Ciencias Aplicadas UPC, Sch Med, Lima, Peru.
   [Hernandez, Adrian V.] Univ Connecticut, Hartford Hosp, Evidence Based Practice Ctr, 80 Seymour St, Hartford, CT 06102 USA.
C3 Universidad Peruana de Ciencias Aplicadas (UPC); Universidad Peruana de
   Ciencias Aplicadas (UPC); University of Connecticut; Hartford Hospital
RP Hernandez, AV (corresponding author), Univ Connecticut, Hartford Hosp, Evidence Based Practice Ctr, 80 Seymour St, Hartford, CT 06102 USA.
EM mariaclaudiapicasso@gmail.com; jlotayraco@gmail.com; jurv1114@gmail.com;
   lepiscean@gmail.com; adrianhernandezdiaz@gmail.com
RI Pasupuleti, Vinay/G-1316-2013; Hernandez, Adrian/ABD-4616-2021
OI Hernandez, Adrian V./0000-0002-9999-4003
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NR 95
TC 44
Z9 46
U1 1
U2 26
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0261-5614
EI 1532-1983
J9 CLIN NUTR
JI Clin. Nutr.
PD JUN
PY 2019
VL 38
IS 3
BP 1117
EP 1132
DI 10.1016/j.clnu.2018.05.021
PG 16
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA IA9QL
UT WOS:000469891800017
PM 29907356
DA 2025-06-11
ER

PT J
AU Kulabas, SS
   Ipek, H
   Tufekci, AR
   Arslan, S
   Demirtas, I
   Ekren, R
   Sezerman, U
   Tumer, TB
AF Kulabas, S. S.
   Ipek, H.
   Tufekci, A. R.
   Arslan, S.
   Demirtas, I.
   Ekren, R.
   Sezerman, U.
   Tumer, T. B.
TI Ameliorative potential of Lavandula stoechas in metabolic
   syndrome via multitarget interactions
SO JOURNAL OF ETHNOPHARMACOLOGY
LA English
DT Article
DE Lavandula stoechas; Insulin resistance; Gluconeogenesis; Glucose uptake;
   Lipolysis; Transcriptome
ID INSULIN-RESISTANCE; MEDICINAL-PLANTS; NITRIC-OXIDE; OXIDATIVE STRESS;
   SKELETAL-MUSCLE; ESSENTIAL OILS; MICE LACKING; PPAR-GAMMA; IN-VITRO; L.
AB Ethnopharmacological importance: Decoction and infusion prepared from aerial parts of Lavandula stoechas L. (L. stoechas) have been traditionally used as remedy against several components of metabolic syndrome (MetS) and associated disorders including type II diabetes and cardiovascular diseases by Anatolian people.
   Aim of the study: The aim is to elucidate the potential ameliorative effects of L. stoechas aqueous extracts on insulin resistance and inflammation models through multitarget in vitro approaches and also to elucidate mechanism of action by analyzing transcriptional and metabolic responses.
   Materials and methods: An aqueous extract was prepared and fractionated to give rise to ethyl acetate (EE) and butanol (BE) extracts. The anti-insulin resistance effects of BE and EE were evaluated on palmitate induced insulin resistance model of H4IIE, C2C12 and 3T3L1 cells by using several metabolic parameters. Specifically, whole genome transcriptome analysis was performed by using microarray over 55.000 genes in control, insulin resistant and EE (25 mu g/mL) treated insulin resistant H4IIE cells. Anti-inflammatory effects of both extracts were analyzed in LPS-stimulated RAW264.7 macrophages.
   Results: Both EE and BE at low doses (25-50 mu g/mL) significantly decreased hepatic gluconeogenesis in H4IIE cell line by suppressing the expression of PEPCK and G6Pase. In C2C12 myotubes, both extracts increased the insulin stimulated glucose uptake more effectively than metformin. Both extracts decreased the isoproterenol induced lipolysis in 3T3L1 cell line. Moreover, they also effectively increased the expression of lipoprotein lipase protein level in insulin resistant myotubes at low doses. EE increased the protein level of PPARy and stimulated the activation AKT in insulin resistant H4IIE and C2C12 cell lines. The results obtained from biochemical assays, mRNA/protein studies and whole genome transcriptome analyses were found to be complementary and provided support for the hypothesis that EE might be biologically active against insulin resistance and act through the inhibition of liver gluconeogenesis and AKT activation. Besides, LPS induced inflammation in RAW264.7 macrophages was mainly inhibited by EE through suppression of iNOS/NO signaling, IMO and COX-2 genes. HPLC-TOF/MS analysis of EE of L. stoechas mainly resulted in caffeic acid, apigenin, luteolin, rosmarinic acid and its methyl ester, 4-hydroxybenzoic acid, vanillic acid, ferrulic acid and salicylic acid.
   Conclusion: Data suggest that EE of L. stoechas contains phytochemicals that can be effective in the treatment/ prevention of insulin resistance and inflammation. These results validate the traditional use of L. stoechas in Anatolia against several metabolic disorders including metabolic syndrome.
C1 [Kulabas, S. S.] Canakkale Onsekiz Mart Univ, Inst Nat & Appl Sci, Grad Program Biol, TR-17100 Canakkale, Turkey.
   [Ipek, H.] Canakkale Onsekiz Mart Univ, Inst Nat & Appl Sci, Grad Program Bioengn, TR-17100 Canakkale, Turkey.
   [Tufekci, A. R.; Demirtas, I.] Cankiri Karatekin Univ, Fac Sci, Dept Chem, TR-18200 Cankiri, Turkey.
   [Arslan, S.] Pamukkale Univ, Fac Art & Sci, Dept Biol, TR-20160 Denizli, Turkey.
   [Ekren, R.] Acibadem Mehmet Ali Aydinlar Univ, Inst Hlth Sci, Grad Program Med Biotechnol, TR-34752 Istanbul, Turkey.
   [Sezerman, U.] Acibadem Mehmet Ali Aydinlar Univ, Inst Hlth Sci, Dept Biostat & Med Informat, TR-34752 Istanbul, Turkey.
   [Tumer, T. B.] Canakkale Onsekiz Mart Univ, Fac Art & Sci, Dept Mol Biol & Genet, TR-17100 Canakkale, Turkey.
C3 Canakkale Onsekiz Mart University; Canakkale Onsekiz Mart University;
   Cankiri Karatekin University; Pamukkale University; Acibadem University;
   Acibadem University; Canakkale Onsekiz Mart University
RP Tumer, TB (corresponding author), Canakkale Onsekiz Mart Univ, Fac Art & Sci, Dept Mol Biol & Genet, TR-17100 Canakkale, Turkey.
EM tumerb@gmail.com
RI TÜFEKÇİ, Ali Rıza/JHT-7229-2023; TÜMER, Tuğba/HPH-3095-2023; Kulabas,
   Seda/O-1373-2013; demirtas, ibrahim/C-7274-2013; SEZERMAN,
   OSMAN/X-6441-2018; EKREN, Rüçhan/AAD-4774-2019
OI Tumer, Tugba/0000-0002-1740-4867; EKREN, Ruchan/0000-0001-6737-7281;
   Sezerman, Osman Ugur/0000-0003-0905-6783
FU Scientific and Technological Research Council of Turkey (TUBITAK)
   [112T442]; Canakkale Onsekiz Mart University [FYL-2015-434,
   FDK-2017-1132]
FX The Scientific and Technological Research Council of Turkey (TUBITAK
   Project ID: 112T442) supported this study. Bioactivity studies related
   with the anti-inflammatory part were partially supported by Canakkale
   Onsekiz Mart University, Scientific Research Projects (FYL-2015-434 and
   FDK-2017-1132).
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NR 55
TC 25
Z9 25
U1 0
U2 46
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0378-8741
J9 J ETHNOPHARMACOL
JI J. Ethnopharmacol.
PD SEP 15
PY 2018
VL 223
BP 88
EP 98
DI 10.1016/j.jep.2018.04.043
PG 11
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA GL7LO
UT WOS:000437383400009
PM 29729383
DA 2025-06-11
ER

PT J
AU Georgiopoulos, G
   Tsioufis, C
   Kalos, T
   Magkas, N
   Roussos, D
   Chrysohoou, C
   Sarri, G
   Syrmali, K
   Georgakopoulos, P
   Tousoulis, D
AF Georgiopoulos, Georgios
   Tsioufis, Costas
   Kalos, Theodoros
   Magkas, Nikos
   Roussos, Dimitris
   Chrysohoou, Christina
   Sarri, Georgia
   Syrmali, Kyriaki
   Georgakopoulos, Panos
   Tousoulis, Dimitrios
TI Serum Uric Acid is Independently Associated with Diastolic Dysfunction
   in Apparently Healthy Subjects with Essential Hypertension
SO CURRENT VASCULAR PHARMACOLOGY
LA English
DT Article
DE Uric acid; diastolic dysfunction; preserved ejection fraction;
   hypertension; heart failure; metabolic syndrome
ID PRESERVED EJECTION FRACTION; CHRONIC HEART-FAILURE; LEFT-VENTRICULAR
   MASS; ENDOTHELIAL DYSFUNCTION; METABOLIC SYNDROME; OXIDATIVE STRESS;
   HYPERURICEMIA; ALLOPURINOL; DIAGNOSIS; PROGRESSION
AB Objectives: Accumulating evidence suggests a direct role of Uric Acid (UA) on Left Ventricular (LV) diastolic function in chronic kidney disease and Heart Failure (HF) patients. Recently, UA has been linked to LV Hypertrophy (LVH) and Diastolic Dysfunction (DD) in women with preserved Ejection Fraction (pEF) but not in corresponding men. We sought to assess if UA could predict indices of DD in hypertensive subjects with pEF independently of gender.
   Method: We consecutively recruited 382 apparently healthy hypertensive subjects (age: 61.7 +/- 10.7, women: 61.3%, median EF: 64%). In 318 patients in sinus rhythm, LV mass-indexed to body surface area-was calculated (LVMI). LVH was set as an LVMI >116g/m(2 )or 96 g/m(2 )in men and women, re- spectively. The ratio of early transmitral peak velocity (E) to the mitral annular early diastolic velocity (Em) was used as an approximation of mean left atrial pressure (E/Em).
   Results: UA [median (interquartile range): 5.4(2) mg/dl] independently predicted E/Em (adjusted coefficient: 1.01, p =0.026) while an interaction term between gender and UA was no significant (p=0.684). An ordinal score of DD was calculated taking into account increased E/Em, left atrium dilatation and LVH. Women with increased UA had 254% increased odds (adjusted OR=2.54, p=0.005) to be classified in the upper range of the DD score.
   Conclusion: In hypertensive subjects without HF, UA is independently associated with the presence of DD in both genders and correlates with its severity in women. Further prospective studies are warranted to evaluate the association of UA with adverse cardiovascular outcomes in high-risk populations such as HF with pEF.
C1 [Georgiopoulos, Georgios; Tsioufis, Costas; Kalos, Theodoros; Magkas, Nikos; Roussos, Dimitris; Chrysohoou, Christina; Sarri, Georgia; Syrmali, Kyriaki; Georgakopoulos, Panos; Tousoulis, Dimitrios] Univ Athens, Hippokration Hosp, Cardiol Clin 1, Med Sch, Athens, Greece.
C3 Hippokration General Hospital; National & Kapodistrian University of
   Athens
RP Tsioufis, C (corresponding author), Univ Athens, Hippokration Hosp, Cardiol Clin 1, Med Sch, Athens, Greece.
EM ktsioufis@hippocratio.gr
RI sarri, gianluca/A-5215-2011; GEORGIOPOULOS, GEORGIOS/AAH-7442-2020
OI Chrysohoou, Christina/0000-0002-6340-3996; GEORGIOPOULOS,
   GEORGIOS/0000-0001-7661-5253; Georgakopoulos,
   Panagiotis/0000-0003-1932-0904
CR [Anonymous], TEHRAN U MED J
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NR 42
TC 11
Z9 13
U1 0
U2 6
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1570-1611
EI 1875-6212
J9 CURR VASC PHARMACOL
JI Current Vascular Pharmacology
PY 2019
VL 17
IS 1
BP 99
EP 106
DI 10.2174/1570161116666171226124959
PG 8
WC Pharmacology & Pharmacy; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Cardiovascular System & Cardiology
GA HM7RO
UT WOS:000459677100014
PM 29278214
DA 2025-06-11
ER

PT J
AU Lin, YK
   Chen, YC
   Kao, YH
   Tsai, CF
   Yeh, YH
   Huang, JL
   Cheng, CC
   Chen, SA
   Chen, YJ
AF Lin, Yung-Kuo
   Chen, Yao-Chang
   Kao, Yu-Hsun
   Tsai, Chin-Feng
   Yeh, Yung-Hsin
   Huang, Jin-Long
   Cheng, Chen-Chuan
   Chen, Shih-Ann
   Chen, Yi-Jen
TI A monounsaturated fatty acid (oleic acid) modulates electrical activity
   in atrial myocytes with calcium and sodium dysregulation
SO INTERNATIONAL JOURNAL OF CARDIOLOGY
LA English
DT Article
DE Atrial fibrillation; Oleic acid; Obesity
ID ACTION-POTENTIAL CHARACTERISTICS; VENTRICULAR MYOCYTES; PULMONARY VEIN;
   CONTRACTILE DYSFUNCTION; NA+-CA2+ EXCHANGE; TRANSIENT OUTWARD; OXIDATIVE
   STRESS; CURRENT AUGMENTS; FIBRILLATION; RISK
AB Background: Obesity and metabolic syndrome are important risk factors for atrial fibrillation. High plasma concentrations of monounsaturated fatty acids, including oleic acid (OLA), are frequently noted in obese individuals and patients with metabolic syndrome. However, it is not clear whether monounsaturated fatty acids (MUFAs) can directly modulate the electrophysiological characteristics of atrial myocytes.
   Methods: Whole-cell patch clamp, indo-1 fluorescence, and Western blot analyses were used to record the action potentials (APs), ionic currents, and protein expressions of HL-1 myocytes incubated with and without (control) OLA (0.5 mM) for 24 h.
   Results: Compared to control myocytes (n = 14), OLA-treated myocytes (n = 16) had shorter APD(90) (65 +/- 6 vs. 85 +/- 6 ms, p < 0.05) and APD(50) (24 +/- 6 vs. 38 +/- 4 ms, p < 0.05) with a higher incidence of delayed after depolarizations (35.7% vs. 7%, p < 0.05), which were suppressed by 4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid (DIDS, a blocker of the calcium-activated chloride current). In addition, OLA-treated myocytes (n = 19) exhibited larger calcium transients (0.54 +/- 0.06 vs. 0.38 +/- 0.05 R410/485, p < 0.05), and sarcoplasmic reticular calcium contents (0.91 +/- 0.05 vs. 0.64 +/- 0.08 R410/485, p < 0.05) than control myocytes (n = 15). OLA-treated myocytes had larger late sodium currents, smaller sodium-calcium exchanger currents, and smaller sodium-potassium pump currents. Moreover OLA-treated myocytes had higher expressions of sarcoplasmic reticular Ca2+-ATPase and calmodulin kinase II, but lower expression of the sodium-potassium ATPase protein than control myocytes.
   Conclusions: MUFAs can regulate atrial electrophysiological characteristics with calcium and sodium dysregulation, which may contribute to atrial arrhythmogenesis. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
C1 [Lin, Yung-Kuo; Chen, Yi-Jen] Taipei Med Univ, Wan Fang Hosp, Div Cardiovasc Med, Taipei, Taiwan.
   [Lin, Yung-Kuo; Kao, Yu-Hsun; Chen, Yi-Jen] Taipei Med Univ, Coll Med, Grad Inst Clin Med, Taipei, Taiwan.
   [Chen, Yao-Chang] Natl Def Med Ctr, Dept Biomed Engn, Taipei, Taiwan.
   [Kao, Yu-Hsun] Taipei Med Univ, Wan Fang Hosp, Dept Med Educ, Taipei, Taiwan.
   [Tsai, Chin-Feng] Chung Shan Med Univ Hosp, Dept Internal Med, Div Cardiol, Taichung, Taiwan.
   [Tsai, Chin-Feng] Chung Shan Med Univ, Sch Med, Taichung, Taiwan.
   [Yeh, Yung-Hsin] Chang Gung Univ, Chang Gung Mem Hosp, Cardiovasc Div 1, Taoyuan, Taiwan.
   [Huang, Jin-Long] Taichung Vet Gen Hosp, Cardiovasc Ctr, Taichung, Taiwan.
   [Huang, Jin-Long] Natl Yang Ming Univ, Fac Med, Taipei 112, Taiwan.
   [Huang, Jin-Long] Natl Yang Ming Univ, Inst Clin Med, Taipei 112, Taiwan.
   [Huang, Jin-Long] Natl Yang Ming Univ, Cardiovasc Res Inst, Taipei 112, Taiwan.
   [Cheng, Chen-Chuan] Chi Mei Hosp, Div Cardiol, Tainan, Taiwan.
   [Chen, Shih-Ann] Natl Yang Ming Univ, Sch Med, Div Cardiol, Taipei 112, Taiwan.
   [Chen, Shih-Ann] Vet Gen Hosp Taipei, Cardiovasc Res Ctr, Taipei, Taiwan.
C3 Taipei Municipal WanFang Hospital; Taipei Medical University; Taipei
   Medical University; National Defense Medical Center; Taipei Medical
   University; Taipei Municipal WanFang Hospital; Chung Shan Medical
   University; Chung Shan Medical University Hospital; Chung Shan Medical
   University; Chang Gung Memorial Hospital; Chang Gung University;
   Taichung Veterans General Hospital; National Yang Ming Chiao Tung
   University; National Yang Ming Chiao Tung University; National Yang Ming
   Chiao Tung University; National Yang Ming Chiao Tung University
RP Chen, YJ (corresponding author), Taipei Med Univ, Wan Fang Hosp, Div Cardiovasc Med, 111 Hsin Lung Rd,Sec 3, Taipei, Taiwan.
EM yjchen@tmu.edu.tw
RI Chen, Fu-Cheng/ABD-1759-2020; Lin, Chin-Yu/IRZ-9664-2023; Yeh,
   Yung-Hsin/ABD-9351-2021; Chen, Yun-Ti/IUM-1935-2023
FU National Science Council of Taiwan [NSC100-2314-B-010-033-MY3,
   NSC100-2628-B-038-001-MY4, NSC101-2314-B-040-017-MY2,
   NSC102-2314-B-016-029-MY2, NSC102-2325-B-010-005,
   NSC102-2628-B-038-002-MY3]; Wan Fang Hospital [101-wf-eva-11,
   101-wf-phd-01, 102-wf-phd-02, 102-wf-eva-15, 103-wf-eva-02, 103swf05];
   Taipei Veterans General Hospital [V103C-042, V102C-128]
FX The current study was supported by grants from the National Science
   Council of Taiwan (NSC100-2314-B-010-033-MY3, NSC100-2628-B-038-001-MY4,
   NSC101-2314-B-040-017-MY2, NSC102-2314-B-016-029-MY2,
   NSC102-2325-B-010-005, and NSC102-2628-B-038-002-MY3), Wan Fang Hospital
   (101-wf-eva-11, 101-wf-phd-01, 102-wf-phd-02, 102-wf-eva-15,
   103-wf-eva-02, and 103swf05), and Taipei Veterans General Hospital
   (V103C-042 and V102C-128).
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NR 48
TC 15
Z9 16
U1 0
U2 11
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0167-5273
EI 1874-1754
J9 INT J CARDIOL
JI Int. J. Cardiol.
PD SEP
PY 2014
VL 176
IS 1
BP 191
EP 198
DI 10.1016/j.ijcard.2014.07.004
PG 8
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA AO0ZG
UT WOS:000341040900039
PM 25064200
DA 2025-06-11
ER

PT J
AU Amor, S
   Martín-Carro, B
   Rubio, C
   Carrascosa, JM
   Hu, W
   Huang, Y
   García-Villalón, AL
   Granado, M
AF Amor, S.
   Martin-Carro, B.
   Rubio, C.
   Carrascosa, J. M.
   Hu, W.
   Huang, Y.
   Garcia-Villalon, A. L.
   Granado, M.
TI Study of insulin vascular sensitivity in aortic rings and endothelial
   cells from aged rats subjected to caloric restriction: Role of
   perivascular adipose tissue
SO EXPERIMENTAL GERONTOLOGY
LA English
DT Article
DE Aging; Insulin; Akt; Perivascular adipose tissue; Aorta; eNOS
ID NITRIC-OXIDE; OXIDATIVE STRESS; POTASSIUM CHANNELS; METABOLIC SYNDROME;
   FOOD RESTRICTION; SKELETAL-MUSCLE; WISTAR RATS; OLD MICE; RESISTANCE;
   DYSFUNCTION
AB The prevalence of metabolic syndrome is dramatically increasing among elderly population. Metabolic syndrome in aged individuals is associated with hyperinsulinemia and insulin resistance both in metabolic tissues and in the cardiovascular system, with this fact being associated with the cardiometabolic alterations associated to this condition. Caloric restriction (CR) improves insulin sensitivity and is one of the dietetic strategies most commonly used to enlarge life and to prevent aging induced cardiovascular alterations. The aim of this study was to analyze the possible beneficial effects of CR in aging-induced vascular insulin resistance both in aortic rings and in primary culture of endothelial cells. In addition, the inflammatory profile of perivascular adipose tissue (PVAT) and its possible role in the impairment of vascular insulin sensitivity associated with aging was also assessed. Three experimental groups of male Wistar rats were used: 3 (3 m), 24 (24 m) fed ad libitum and 24 months old rats subjected to 20% CR during their three last months of life (24 m-CR). Aorta rings surrounded or not by PVAT were mounted in an organ bath and precontracted with phenylephrine (10(-7.5) M). Changes in isometric tension were recorded in response to cumulative insulin concentrations (10(-8) -10(-5.5) M) in the presence or absence of L-NAME (10(-4) M). Aortic rings and primary aortic endothelial cells were incubated in presence/absence of insulin (10(-7)M) and the activation of the PI3K/Akt and MAPK pathways as well as nitrite and nitrates concentrations and the mRNA levels of eNOS, insulin receptor, and GLUT-4 were assessed. CR prevented the aging-induced decrease in the vasodilator response to insulin and the aging-induced increase in the vasoconstrictor response to high insulin concentrations. Changes between 24 m and 24 m-CR aorta rings were abolished in the presence of L-NAME. CR induced-improvement in insulin vascular sensitivity was related with activation of the PI3K/Akt both in aortic rings and in aortic endothelial cells in response to insulin. CR attenuated the overexpression of iNOS, TNF-alpha and IL-1 beta in the PVAT of aged rats although aortic rings surrounded by PVAT from 24 m rats showed and increased vasorelaxation in response to insulin compared to aortic rings from 3 m and 24 m-CR rats. In conclusion, a moderate protocol of CR improves insulin vascular sensitivity and prevents the aging induced overexpression of pro-inflammatory cytokines in PVAT.
C1 [Amor, S.; Martin-Carro, B.; Garcia-Villalon, A. L.; Granado, M.] Univ Autonoma Madrid, Dept Fisiol, Fac Med, C Arzobispo Morcillo 2, Madrid 28029, Spain.
   [Rubio, C.; Carrascosa, J. M.] Univ Autonoma Madrid, Fac Ciencias, Dept Bioquim & Biol Mol, Madrid, Spain.
   [Hu, W.; Huang, Y.] Chinese Univ Hong Kong, Fac Med, Sch Biomed Sci, Inst Vasc Med, Hong Kong, Hong Kong, Peoples R China.
   [Granado, M.] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr, Madrid, Spain.
C3 Autonomous University of Madrid; Autonomous University of Madrid;
   Chinese University of Hong Kong; CIBER - Centro de Investigacion
   Biomedica en Red; CIBEROBN; Instituto de Salud Carlos III
RP Granado, M (corresponding author), Univ Autonoma Madrid, Dept Fisiol, Fac Med, C Arzobispo Morcillo 2, Madrid 28029, Spain.
EM miriam.granado@uam.es
RI Carrascosa, Jose/ABE-3526-2021; Garcia-Villalon, Angel/AAA-3067-2019;
   Martin Carro, Beatriz/F-1481-2018; Huang, Yu/K-2866-2017; Granado,
   Miriam/B-8978-2017
OI Martin Carro, Beatriz/0000-0002-1683-6617; Huang,
   Yu/0000-0002-1277-6784; Rubio, Carmen/0000-0002-8275-5866; Granado,
   Miriam/0000-0001-9178-8822
FU Universidad Autonoma de Madrid; Banco Santander
FX This work has been funded by the Universidad Autonoma de Madrid and
   Banco Santander in the 2nd Call for International Cooperation projects
   with Asia (year 2015).
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NR 57
TC 12
Z9 12
U1 0
U2 2
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0531-5565
EI 1873-6815
J9 EXP GERONTOL
JI Exp. Gerontol.
PD AUG
PY 2018
VL 109
SI SI
BP 126
EP 136
DI 10.1016/j.exger.2017.10.017
PG 11
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA GP6GC
UT WOS:000440975100016
PM 29055722
DA 2025-06-11
ER

PT J
AU Brzezinski, RY
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   Shapira, I
   Zeltser, D
   Berliner, S
   Rogowski, O
   Eldor, R
   Shenhar-Tsarfaty, S
AF Brzezinski, Rafael Y.
   Etz-Hadar, Inbal
   Grupper, Ayelet
   Ehrenwald, Michal
   Shapira, Itzhak
   Zeltser, David
   Berliner, Shlomo
   Rogowski, Ori
   Eldor, Roy
   Shenhar-Tsarfaty, Shani
TI Sex difference in the risk for exercise-induced albuminuria correlates
   with hemoglobin A1C and abnormal exercise ECG test findings
SO CARDIOVASCULAR DIABETOLOGY
LA English
DT Article
DE Albuminuria; Exercise; Stress test; Sex difference; Gender; HbA1c;
   Microvascular; Women-heart disease; Risk scores
ID GENDER-DIFFERENCES; MICROVASCULAR DYSFUNCTION; CARDIOVASCULAR OUTCOMES;
   DISEASE; MICROALBUMINURIA; COMPLICATIONS; MORTALITY; WOMEN;
   INFLAMMATION; NEPHROPATHY
AB Background: Albuminuria is an established marker for endothelial dysfunction and cardiovascular risk in diabetes and prediabetes. Exercise induced albuminuria (EiA) appears earlier and may be a more sensitive biomarker for renal endothelial damage. We sought to examine the association between EiA, parameters of the metabolic syndrome, A1C levels, exercise ECG test results and sex related differences in a large cohort of healthy, pre-diabetic and diabetic subjects.
   Methods: A total of 3029 participants from the Tel-Aviv Medical Center Inflammation Survey cohort (mean age 46 years, 73% men) were analyzed. Multiple physiologic and metabolic parameters including A1C were collected and albuminuria was measured in all subjects before and immediately after completing an exercise ECG test.
   Results: Exercise increased urinary albumin to creatinine ratio (Delta EiA) by 2.8 (0-13.6) mg/g for median (IQR) compared to rest albuminuria (p < 0.001). An increase in Delta EiA was observed with accumulating parameters of the metabolic syndrome. Delta EiA showed significant interaction with sex and A1C levels; i.e. women with A1C > 6.5% had an increased risk of higher Delta EiA (p < 0.001). Using a cutoff of.EiA > 13 mg/g (top quartile) we found that women with Delta EiA > 13 mg/g were at greater risk for abnormal exercise ECG findings, (OR = 2.7, p = 0.001).
   Conclusion: Exercise promotes excessive urinary albumin excretion in dysmetabolic patients. In women, a significant correlation exists between Delta EiA and A1C levels. A cutoff of Delta EiA > 13 mg/g in women may be used to identify populations at risk for abnormal exercise ECG test findings and perhaps increased cardiovascular risk. Future studies will be needed to further validate the usefulness of Delta EiA as a biomarker for cardiovascular risk in women with and without diabetes.
C1 [Brzezinski, Rafael Y.; Etz-Hadar, Inbal; Ehrenwald, Michal; Shapira, Itzhak; Zeltser, David; Berliner, Shlomo; Rogowski, Ori; Shenhar-Tsarfaty, Shani] Tel Aviv Univ, Tel Aviv Sourasky Med Ctr, Dept Internal Med C D&E, 6 Weizmann St, IL-64239 Tel Aviv, Israel.
   [Brzezinski, Rafael Y.; Etz-Hadar, Inbal; Grupper, Ayelet; Ehrenwald, Michal; Shapira, Itzhak; Zeltser, David; Berliner, Shlomo; Rogowski, Ori; Shenhar-Tsarfaty, Shani] Tel Aviv Univ, Sackler Fac Med, 6 Weizmann St, IL-64239 Tel Aviv, Israel.
   [Grupper, Ayelet] Tel Aviv Univ, Nephrol Dept, Tel Aviv Sourasky Med Ctr, Tel Aviv, Israel.
   [Eldor, Roy] Tel Aviv Sourasky Med Ctr, Diabet Unit, Inst Endocrinol Metab & Hypertens, Tel Aviv, Israel.
C3 Tel Aviv University; Sackler Faculty of Medicine; Tel Aviv Sourasky
   Medical Center; Tel Aviv University; Sackler Faculty of Medicine; Tel
   Aviv University; Sackler Faculty of Medicine; Tel Aviv Sourasky Medical
   Center; Tel Aviv University; Sackler Faculty of Medicine; Tel Aviv
   Sourasky Medical Center
RP Shenhar-Tsarfaty, S (corresponding author), Tel Aviv Univ, Tel Aviv Sourasky Med Ctr, Dept Internal Med C D&E, 6 Weizmann St, IL-64239 Tel Aviv, Israel.; Shenhar-Tsarfaty, S (corresponding author), Tel Aviv Univ, Sackler Fac Med, 6 Weizmann St, IL-64239 Tel Aviv, Israel.
EM shanis@tlvmc.gov.il
RI Zeltser, David/LYO-6304-2024; Eldor, Roy/AAD-4397-2022
OI Shenhar-Tsarfaty, Shani/0000-0002-8268-1799; Eldor,
   Roy/0000-0002-1151-1370; Grupper, Ayelet/0000-0002-5590-9428
FU Chaia Hamer Foundation (The Sackler Faculty of medicine)
FX This study was supported by a grant from the Israel Hamer, Frida Hamer
   and Chaia Hamer Foundation (The Sackler Faculty of medicine).
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NR 51
TC 15
Z9 15
U1 0
U2 3
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1475-2840
J9 CARDIOVASC DIABETOL
JI Cardiovasc. Diabetol.
PD JUN 23
PY 2017
VL 16
AR 79
DI 10.1186/s12933-017-0560-4
PG 9
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism
GA EY4NT
UT WOS:000403955500001
PM 28645281
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Hristova, MG
AF Hristova, M. G.
TI Metabolic syndrome - From the neurotrophic hypothesis to a theory
SO MEDICAL HYPOTHESES
LA English
DT Article
ID NERVE-GROWTH-FACTOR; CHRONIC-FATIGUE-SYNDROME; PITUITARY-ADRENAL-AXIS;
   PANCREATIC BETA-CELLS; INSULIN-RESISTANCE; ADIPOSE-TISSUE;
   PARAVENTRICULAR NUCLEUS; TESTOSTERONE DEFICIENCY; ADIPONECTIN LEVELS;
   PHYSICAL-ACTIVITY
AB Metabolic syndrome (MetS) is a complex and heterogeneous disease characterized by central obesity, impaired glucose metabolism, dyslipidemia, arterial hypertension, insulin resistance and high-sensitivity C-reactive protein. In 2006, a neurotrophic hypothesis of the etiopathogenesis of MetS was launched. This hypothesis considered the neurotrophins a key factor in MetS development. Chronic inflammatory and/or psychoemotional distress provoke a series of neuroimmunoendocrine interactions such as increased tissue and plasma levels of proinflammatory cytokines and neurotrophins, vegetodystonia, disbalance of neurotransmitters, hormones and immunity markers, activation of the hypothalamo-pituitary-adrenal axis, insulin resistance, and atherosclerosis. An early and a late clinical stage in the course of MetS are defined. Meanwhile, evidence of supporting results from the world literature accumulates. This enables the transformation of the definition of the neurotrophic hypothesis into a neurotrophic theory of MetS. The important role of two neurotrophic factors, i.e. the nerve growth factor and brain-derived neurotrophic factor as well as of the proinflammatory cytokines, neurotransmitters, adipokines and, especially, of leptin for the development of MetS, obesity and type 2 diabetes mellitus is illustrated. There are reliable scientific arguments that the metabotrophic deficit due to reduced neurotrophins could be implicated in the pathogenesis of MetS, type 2 diabetes mellitus, and atherosclerosis as well. A special attention is paid to the activity of the hypothalamo-pituitary-adrenal axis after stress. The application of the neurotrophic theory of MetS could contribute to the etiological diagnosis and individualized management of MetS by eliminating the chronic distress, hyponeurotrophinemia and consequent pathology. It helps estimating the risk, defining the prognosis and implementing the effective prevention of this socially significant disease as evidenced by the dramatic recent growth of the world publication output on this interdisciplinary topic. (C) 2013 Elsevier Ltd. All rights reserved.
C1 Med Ctr Varna, Div Endocrinol, BG-9003 Varna, Bulgaria.
RP Hristova, MG (corresponding author), Med Ctr Varna, Div Endocrinol, 53 Kiril & Metodiy St, BG-9003 Varna, Bulgaria.
EM drmhristova@gmail.com
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NR 185
TC 29
Z9 31
U1 0
U2 30
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0306-9877
EI 1532-2777
J9 MED HYPOTHESES
JI Med. Hypotheses
PD OCT
PY 2013
VL 81
IS 4
BP 627
EP 634
DI 10.1016/j.mehy.2013.07.018
PG 8
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 243ZO
UT WOS:000326357100024
PM 23899630
DA 2025-06-11
ER

PT J
AU Goliasch, G
   Wiesbauer, F
   Kastl, SP
   Katsaros, KM
   Blessberger, H
   Maurer, G
   Schillinger, M
   Huber, K
   Wojta, J
   Speidl, WS
AF Goliasch, Georg
   Wiesbauer, Franz
   Kastl, Stefan P.
   Katsaros, Katharina M.
   Blessberger, Hermann
   Maurer, Gerald
   Schillinger, Martin
   Huber, Kurt
   Wojta, Johann
   Speidl, Walter S.
TI Premature myocardial infarction is associated with low serum levels of
   Wnt-1
SO ATHEROSCLEROSIS
LA English
DT Article
DE Wnt; Premature myocardial infarction; Risk factors
ID RECEPTOR-RELATED PROTEIN-5; BETA-CATENIN; LESS-THAN-OR-EQUAL-TO-40
   YEARS; OXIDATIVE STRESS; CELL FACTOR; MUTATION; ATHEROSCLEROSIS;
   PROLIFERATION; ACTIVATION; PROGNOSIS
AB Objective: Besides its effects on glucose and lipid metabolism, the Wnt pathway has been increasingly implicated in the regulation of proliferation, migration and survival of vascular cells. In addition, defective Wnt signaling has been identified in a family with autosomal dominant early coronary artery disease. The aim of this study was to investigate whether premature coronary artery disease is associated with features of decreased Wnt signaling.
   Methods and results: We prospectively enrolled 100 consecutive young survivors of myocardial infarction (MI <= 40 years of age) from two high-volume cardiac catheterization centers and 100 sex and age matched hospital controls. We determined serum levels of Wnt-1 and its antagonist Dkk-1 by ELISA. MI patients showed significantly lower Wnt-1 levels as compared to controls (151 ng/mL, IQR 38-473 ng/mL vs. 233 ng/mL, IQR 62-1756; p < 0.005) whereas Dkk-1 was not different at baseline. Wnt-1 levels remained stable over time, whereas Dkk-1 significantly increased at one-year follow-up from 3557, IQR 2306-5810 pg/mL to 4973, IQR 3293-7093 pg/mL (p < 0.001). In the stable phase of the disease, Wnt-1 levels were lower (p < 0.005) and Dkk-1 levels were significantly higher (p < 0.001) as compared to controls. Wnt-1 at follow-up was associated with glucose, HbA1c, non-HDL-, HDL-cholesterol and triglyceride levels but no other features of the metabolic syndrome.
   Conclusion: This study establishes an association between low Wnt-1 and high Dkk-1 serum levels and premature myocardial infarction. Wnt-1 is associated with markers of glucose and lipid metabolism. Further research elucidating the role of Wnt pathways in premature coronary artery disease and metabolic syndrome is warranted. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
C1 [Goliasch, Georg; Wiesbauer, Franz; Kastl, Stefan P.; Katsaros, Katharina M.; Blessberger, Hermann; Maurer, Gerald; Schillinger, Martin; Wojta, Johann; Speidl, Walter S.] Med Univ Vienna, Dept Internal Med 2, A-1090 Vienna, Austria.
   [Kastl, Stefan P.; Katsaros, Katharina M.; Wojta, Johann] Ludwig Boltzmann Fdn Cardiovasc Res, Vienna, Austria.
   [Huber, Kurt] Dept Med 3, Vienna, Austria.
C3 Medical University of Vienna; Ludwig Boltzmann Institute
RP Speidl, WS (corresponding author), Med Univ Vienna, Dept Internal Med 2, Waehringer Guertel 18-20, A-1090 Vienna, Austria.
EM walter.speidl@meduniwien.ac.at
RI Speidl, Walter/AAU-8830-2020; Schillinger, Martin/IQU-4166-2023; Huber,
   Kurt/ADE-3927-2022; Wojta, Johann/AAC-8433-2020
OI Huber, Kurt/0000-0002-7934-5524; Wojta, Johann/0000-0002-1282-9276;
   Speidl, Walter/0000-0002-7267-3138; Maurer, Gerald/0000-0002-9043-7657;
   Goliasch, Georg/0000-0002-6219-6104
FU Ludwig Boltzmann Foundation for Cardiovascular Research; Association for
   Promotion of Research in Arteriosclerosis, Thrombosis and Vascular
   Biology
FX This work was supported by the Ludwig Boltzmann Foundation for
   Cardiovascular Research and by the Association for Promotion of Research
   in Arteriosclerosis, Thrombosis and Vascular Biology.
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NR 41
TC 47
Z9 48
U1 0
U2 6
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0021-9150
EI 1879-1484
J9 ATHEROSCLEROSIS
JI Atherosclerosis
PD MAY
PY 2012
VL 222
IS 1
BP 251
EP 256
DI 10.1016/j.atherosclerosis.2012.02.017
PG 6
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 928DJ
UT WOS:000302960600040
PM 22391424
DA 2025-06-11
ER

PT J
AU Lee, SY
   Wang, TY
   Chen, SL
   Chang, YH
   Chen, PS
   Huang, SY
   Tzeng, NS
   Wang, LJ
   Lee, IH
   Chen, KC
   Yang, YK
   Hong, JS
   Lu, RB
AF Lee, Sheng-Yu
   Wang, Tzu-Yun
   Chen, Shiou-Lan
   Chang, Yun-Hsuan
   Chen, Po-See
   Huang, San-Yuan
   Tzeng, Nian-Sheng
   Wang, Liang-Jen
   Lee, I-Hui
   Chen, Kao-Ching
   Yang, Yen-Kuang
   Hong, Jau-Shyong
   Lu, Ru-Band
TI Combination of dextromethorphan and memantine in treating bipolar
   spectrum disorder: a 12-week double-blind randomized clinical trial
SO INTERNATIONAL JOURNAL OF BIPOLAR DISORDERS
LA English
DT Article
DE Bipolar spectrum disorder; Bipolar II disorder; Dextromethorphan;
   Memantine; Cytokines; BDNF
ID C-REACTIVE PROTEIN; NEUROTROPHIC FACTOR; METABOLIC SYNDROME; DOSE
   DEXTROMETHORPHAN; OXIDATIVE STRESS; II DISORDER; BDNF LEVELS; BRAIN;
   INFLAMMATION; METAANALYSIS
AB Background The aim of this study is to determine whether adding combination of agents with anti-inflammatory and neurotrophic effects is more efficacious than mood stabilizer alone in improving clinical symptoms, plasma brain-derived neurotrophic factor (BDNF), cytokine levels, and metabolic profiles in patients with bipolar spectrum disorder. Methods In a randomized, double-blind, controlled 12-week clinical trial, patients with moderate mood symptoms (HDRS >= 18 or YMRS >= 14) were recruited. The patients were randomly assigned to a group while still undergoing regular valproate (VPA) treatments: VPA + dextromethorphan (DM) (30 mg/day) + memantine (MM) (5 mg/day) (DM30 + MM5) (n = 66), VPA + DM (30 mg/day) (DM30) (n = 69), VPA + MM (5 mg/day) (MM5) (n = 66), or VPA + Placebo (Placebo) (n = 69). Symptom severity, immunological parameters [plasma tumor necrosis factor (TNF)-alpha and C-reactive protein (CRP)] and plasma brain-derived neurotrophic factor (BDNF) were regularly examined. Metabolic profiles [cholesterol, triglycerides, glycosylated hemoglobin (HbA1C), fasting serum glucose, body mass index (BMI)] were measured at baseline and at 2, 8, and 12 weeks. Results Depression scores were significantly (P = 0.03) decreases and BDNF levels significantly (P = 0.04) increased in the DM30 + MM5 group than in the Placebo group. However, neither depressive scores nor BDNF levels were significantly different between the DM30, MM5, and Placebo groups. Changes in certain plasma cytokine and BDNF levels were significantly correlated with metabolic parameters. Conclusion We concluded that add-on DM30 + MM5 was significantly more effective than placebo for clinical symptoms and plasma BDNF levels. Additional studies with larger samples and mechanistic studies are necessary to confirm our findings.
C1 [Lee, Sheng-Yu] Kaohsiung Vet Gen Hosp, Dept Psychiat, Kaohsiung, Taiwan.
   [Lee, Sheng-Yu] Kaohsiung Med Univ, Coll Med, Sch Med, Dept Psychiat, Kaohsiung, Taiwan.
   [Lee, Sheng-Yu] Natl Yang Ming Univ, Coll Med, Dept Psychiat, Taipei, Taiwan.
   [Lee, Sheng-Yu; Wang, Tzu-Yun; Chen, Po-See; Lee, I-Hui; Chen, Kao-Ching; Yang, Yen-Kuang; Lu, Ru-Band] Natl Cheng Kung Univ, Natl Cheng Kung Univ Hosp, Coll Med, Dept Psychiat, 138 Sheng Li Rd, Tainan 70428, Taiwan.
   [Chen, Shiou-Lan] Kaohsiung Med Univ, Sch Med, Dept Neurol, Kaohsiung, Taiwan.
   [Chang, Yun-Hsuan] Asia Univ, Coll Med & Hlth Sci, Dept Psychol, Taichung, Taiwan.
   [Huang, San-Yuan; Tzeng, Nian-Sheng] Natl Def Med Ctr, Triserv Gen Hosp, Dept Psychiat, Taipei, Taiwan.
   [Wang, Liang-Jen] Kaohsiung Chang Gung Mem Hosp, Dept Child & Adolescent Psychiat, Kaohsiung, Taiwan.
   [Wang, Liang-Jen] Chang Gung Univ, Coll Med, Kaohsiung, Taiwan.
   [Hong, Jau-Shyong] NIEHS, Lab Toxicol & Pharmacol, NIH, POB 12233, Res Triangle Pk, NC 27709 USA.
   [Lu, Ru-Band] Yanjiao Furen Hosp, Hebei, Hebei, Peoples R China.
   [Lu, Ru-Band] Natl Cheng Kung Univ, Addict Res Ctr, Tainan, Taiwan.
C3 Kaohsiung Veterans General Hospital; Kaohsiung Medical University;
   National Yang Ming Chiao Tung University; National Cheng Kung
   University; National Cheng Kung University Hospital; Kaohsiung Medical
   University; Asia University Taiwan; National Defense Medical Center;
   Tri-Service General Hospital; Chang Gung Memorial Hospital; Chang Gung
   University; National Institutes of Health (NIH) - USA; NIH National
   Institute of Environmental Health Sciences (NIEHS); National Cheng Kung
   University
RP Lu, RB (corresponding author), Natl Cheng Kung Univ, Natl Cheng Kung Univ Hosp, Coll Med, Dept Psychiat, 138 Sheng Li Rd, Tainan 70428, Taiwan.
EM rblu@mail.ncku.edu.tw
RI Chen, Han-Shen/E-5881-2018; Tzeng, Nian-Sheng/AAU-4945-2021; Wang,
   Liang-Jen/AAR-1089-2020; Chen, Shiou/AEV-7272-2022; Chen,
   Po/AAA-6492-2021; Hong, Jau-shyong/F-1920-2019; Chen,
   Chih-Ping/D-1416-2014; Chang, Hui/AGD-4270-2022
OI Chang, Yun-Hsuan/0000-0001-8662-2457
FU Taiwan Ministry of Science and Technology [MOST 103-2622-B-006-006-CC2,
   MOST 104-2622-B-006-006-CC2, MOST 103-2314-B-075B-006]; Taiwan
   Department of Health [DOH95-TDM-113-055]; Taiwan National Health
   Research Institute [NHRI-EX97-9738NI]; National Cheng Kung University
   Project for Promoting Academic Excellence and Developing World Class
   Research Centers
FX This work was supported in part by MOST 103-2622-B-006-006-CC2 (to RBL),
   MOST 104-2622-B-006-006-CC2 (to RBL), MOST 103-2314-B-075B-006 (to SYL)
   from the Taiwan Ministry of Science and Technology; Grant
   DOH95-TDM-113-055 (to RBL) from the Taiwan Department of Health, Grant
   NHRI-EX97-9738NI (to RBL) from the Taiwan National Health Research
   Institute, and by a grant from the National Cheng Kung University
   Project for Promoting Academic Excellence and Developing World Class
   Research Centers.
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NR 56
TC 9
Z9 9
U1 1
U2 6
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 2194-7511
J9 INT J BIPOLAR DISORD
JI INT. J. BIBPOLAR DISORD.
PD MAR 2
PY 2020
VL 8
IS 1
AR 11
DI 10.1186/s40345-019-0174-8
PG 12
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA KS9QT
UT WOS:000518645700002
PM 32115672
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Lee, YJ
   Lim, YH
   Shin, CH
   Kim, BN
   Kim, JI
   Hong, YC
   Cho, YM
   Lee, YA
AF Lee, Yun Jeong
   Lim, Youn-Hee
   Shin, Choong Ho
   Kim, Bung-Nyun
   Kim, Johanna Inhyang
   Hong, Yun-Chul
   Cho, Yong Min
   Lee, Young Ah
TI Relationship between bisphenol A, bisphenol S, and bisphenol F and serum
   uric acid concentrations among school-aged children
SO PLOS ONE
LA English
DT Article
ID NUTRITION EXAMINATION SURVEY; URINARY CONCENTRATIONS; BLOOD-PRESSURE;
   METABOLIC SYNDROME; OXIDATIVE STRESS; NATIONAL-HEALTH; UNITED-STATES;
   HYPERURICEMIA; EXPOSURE; OBESITY
AB Background
   Hyperuricemia has a suspected relationship with hypertension, metabolic syndrome, kidney disease, and cardiovascular disease. Endocrine disruptors may affect uric acid metabolism; however, few epidemiologic studies have been performed in children regarding newly developed bisphenol A (BPA) substitutes. We evaluated the associations between BPA, bisphenol S (BPS), and bisphenol F (BPF) exposure and serum uric acid concentrations in 6-year-old Korean children.
   Methods
   From the Environment and Development of Children cohort study, six-year-old children (N = 489; 251 boys) who underwent an examination during 2015-2017 were included. Anthropometry, questionnaires, and biological samples were evaluated. BPA, BPS, and BPF levels were measured from spot urine samples, and log-transformed or categorized into groups for analysis. We constructed linear regression models adjusting for age, sex, urinary creatinine levels, body mass index z-scores, and estimated glomerular filtration rates.
   Results
   Mean serum uric level was 4.2 mg dL(-1) (0.8 SD) without sex-differences. Among the three bisphenols, higher BPS exposure was associated with increased serum uric acid concentrations (P-value for trend = 0.002). When BPS levels were categorized into three groups (non-detection < 0.02 mu g L-1 vs. medium BPS; 0.02-0.05 mu g L-1 vs. high BPS > 0.05 mu g L-1), the high BPS group showed higher serum uric acid concentrations (by 0.26 mg dL(-1), P= 0.003) than the non-detection group after adjusting for covariates, which was significant in boys but not girls.
   Discussions
   Urinary BPS levels was positively associated with serum uric acid concentrations in 6-year-old children, and the association was more pronounced in boys. Considering the increasing use of BPS and concerning effect of hyperuricemia on health outcomes, their positive relationship should be investigated further.
C1 [Lee, Yun Jeong; Shin, Choong Ho; Lee, Young Ah] Seoul Natl Univ, Childrens Hosp, Dept Pediat, Seoul, South Korea.
   [Lee, Yun Jeong; Shin, Choong Ho; Lee, Young Ah] Seoul Natl Univ, Coll Med, Dept Pediat, Seoul, South Korea.
   [Lim, Youn-Hee] Univ Copenhagen, Dept Publ Hlth, Sect Environm Hlth, Copenhagen, Denmark.
   [Lim, Youn-Hee; Hong, Yun-Chul] Seoul Natl Univ, Med Res Ctr, Inst Environm Med, Seoul, South Korea.
   [Lim, Youn-Hee; Hong, Yun-Chul] Seoul Natl Univ, Coll Med, Environm Hlth Ctr, Seoul, South Korea.
   [Kim, Bung-Nyun] Seoul Natl Univ Hosp, Dept Psychiat, Div Children & Adolescent Psychiat, Seoul, South Korea.
   [Kim, Johanna Inhyang] Hanyang Univ, Med Ctr, Dept Psychiat, Seoul, South Korea.
   [Hong, Yun-Chul] Seoul Natl Univ, Coll Med, Dept Prevent Med, Seoul, South Korea.
   [Cho, Yong Min] SeoKyeong Univ, Dept Nano Chem & Biol Engn, Seoul, South Korea.
C3 Seoul National University (SNU); Seoul National University Hospital;
   Seoul National University (SNU); University of Copenhagen; Seoul
   National University (SNU); Seoul National University (SNU); Seoul
   National University (SNU); Seoul National University Hospital; Hanyang
   University; Seoul National University (SNU); Seokyeong University
RP Lee, YA (corresponding author), Seoul Natl Univ, Childrens Hosp, Dept Pediat, Seoul, South Korea.; Lee, YA (corresponding author), Seoul Natl Univ, Coll Med, Dept Pediat, Seoul, South Korea.
EM nina337@snu.ac.kr
RI Kim, Byung-Hak/AAY-9891-2020; Lee, Jung-Seok/HDN-4819-2022; Hong,
   Yun-Chul/J-5725-2012; Lee, Jong-Young/M-6319-2013
OI Cho, Yong Min/0000-0002-8999-8916
FU Environmental Health Center Program - Korean Ministry of Environment
   [18162MFDS121]; Ministry of Food and Drug Safety
FX HYC, 18162MFDS121, Environmental Health Center Program funded by the
   Korean Ministry of Environment and from the Ministry of Food and Drug
   Safety [https://www.mfds.go.kr/eng].
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NR 59
TC 15
Z9 16
U1 2
U2 21
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PY 2022
VL 17
IS 6
AR e0268503
DI 10.1371/journal.pone.0268503
PG 13
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 3Y3FU
UT WOS:000843613300037
PM 35709251
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Coenen, KR
   Hasty, AH
AF Coenen, Kimberly R.
   Hasty, Alyssa H.
TI Obesity potentiates development of fatty liver and insulin resistance,
   but not atherosclerosis, in high-fat diet-fed agouti LDLR-deficient mice
SO AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
LA English
DT Article
DE metabolic syndrome; hyperlipidemia; mouse model
ID APOLIPOPROTEIN E-DEFICIENT; METABOLIC-SYNDROME; RECEPTOR-DEFICIENT;
   ADIPOSE-TISSUE; OXIDATIVE STRESS; HEART-DISEASE; INFLAMMATION; YELLOW;
   MODELS; INCREASE
AB Obesity is increasing at an alarming rate, and its related disorders are placing a considerable strain on our healthcare system. Although they are not always coincident, obesity is often accompanied by hyperlipidemia. Both obesity and hyperlipidemia are independently associated with atherosclerosis, nonalcoholic fatty liver disease (NAFLD), and insulin resistance (IR). Thus, we sought to determine the relative contributions of obesity and hyperlipidemia to these associated pathologies. Obese agouti (A(y)/a) mice and their littermate controls (a/a) were placed on an LDL receptor (LDLR)(-/-) background. At 4 mo of age, mice were either maintained on chow diet (CD) or placed on Western diet (WD) for 12 wk. These genetic and dietary manipulations yielded four experimental groups: 1) lean, a/a; LDLR-/- CD; 2) genetic-induced obesity (GIO), A(y)/a; LDLR-/- CD; 3) diet-induced obesity (DIO), a/a; LDLR-/- WD; and 4) genetic-plus diet-induced obesity (GIO/DIO), A(y)/a; LDLR-/- WD. Lipoprotein profiles revealed increased VLDL and LDL particles in WD-fed mice compared with CD-fed controls. The hyperlipidemia present in this mouse model was the result of both increased hepatic triglyceride production and delayed lipoprotein clearance from the plasma. Both WD- fed groups exhibited similar levels of atherosclerotic lesion area, with increased obesity in the GIO/DIO group having no impact on atherogenesis. However, the severe obesity in the GIO/DIO group did aggravate NAFLD and IR. These findings suggest that, although obesity and hyperlipidemia exert individual pathological effects, the combination of the two has the potential to exert an additive effect on NAFLD and IR but not atherosclerosis in this mouse model.
C1 Vanderbilt Univ, Med Ctr, Dept Physiol & Mol Biophys, Nashville, TN 37232 USA.
C3 Vanderbilt University
RP Hasty, AH (corresponding author), Vanderbilt Univ, Med Ctr, Dept Physiol & Mol Biophys, Rm 702,Light Hall, Nashville, TN 37232 USA.
EM alyssa.hasty@vanderbilt.edu
RI Hasty, Alyssa/AAA-2757-2020
OI Hasty, Alyssa/0000-0001-7302-8045
FU NIDDK NIH HHS [DK058404, DK20593, DK59637] Funding Source: Medline
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NR 34
TC 27
Z9 29
U1 0
U2 3
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0193-1849
J9 AM J PHYSIOL-ENDOC M
JI Am. J. Physiol.-Endocrinol. Metab.
PD AUG
PY 2007
VL 293
IS 2
BP E492
EP E499
DI 10.1152/ajpendo.00171.2007
PG 8
WC Endocrinology & Metabolism; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Physiology
GA 196CA
UT WOS:000248458100008
PM 17566116
DA 2025-06-11
ER

PT J
AU Liu, YT
   Kong, B
   Ma, H
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AF Liu, Yuting
   Kong, Bo
   Ma, Huan
   Guo, Lan
   Bai, Bingqing
   Yu, Xueju
   Liu, Fengyao
   Wang, Haochen
   Fei, Hongwen
   Geng, Qingshan
   Jiang, Wei
TI CONSISTENCY OF POSITRON EMISSION TOMOGRAPHY AND MYOCARDIAL CONTRAST
   ECHOCARDIOGRAPHY IN DIAGNOSING MENTAL STRESS-INDUCED MYOCARDIAL
   ISCHEMIA: STUDY PROTOCOL OF A PROSPECTIVE STUDY-BACKGROUND, DESIGN AND
   METHOD
SO ULTRASOUND IN MEDICINE AND BIOLOGY
LA English
DT Article
DE Mental stress-induced myocardial ischemia; Positron emission tomography;
   Echocardiography
ID CORONARY-ARTERY-DISEASE; CARDIAC SYNDROME-X; BLOOD-FLOW; MICROVASCULAR
   DYSFUNCTION; CLINICAL CHARACTERISTICS; COMPUTED-TOMOGRAPHY; PERFUSION
   RESERVE; HEART-FAILURE; STRAIN-RATE; REPRODUCIBILITY
AB Mental stress-induced myocardial ischemia (MSIMI) has attracted increasing attention in the last 30 y. Positron emission tomography/computed tomography (PET/CT) is among the most accurate methods for evaluating myocardial perfusion. Even so, echocardiography seems to be a more harmless option when the radiation exposure and high expense of PET/CT are considered. To date, no previous studies have compared the consistency between echocardiography and PET/CT in the diagnosis of MSIMI. The primary aim of this research was to compare the consistency of myocardial contrast echocardiography and PET/CT in diagnosing MSIMI in women with angina symptom/ischemia but no obstructive coronary artery disease (INOCA). Fifty adult female patients with INOCA were recruited for a 12-min-long mental stress test. Each patient underwent both echocardiography and PET/CT at baseline and during mental stress testing; the interval between the two examinations was 1-3 d and the sequence was assigned naturally. MSIMI is defined by a summed difference score (SDS) >= 3 on PET-CT during mental stress testing. It is also defined by new abnormal wall motion, ejection fraction reduction >= 5%, and/or development of ischemic ST change on the electrocardiogram during mental stress testing. This study examined the consistency of PET/CT and myocardial contrast echocardiography in diagnosing MSIMI. (E-mail: gengqingshan@gdph.org.cn) (C) 2020 World Federation for Ultrasound in Medicine & Biology. All rights reserved.
C1 [Liu, Yuting; Yu, Xueju; Liu, Fengyao; Wang, Haochen] South China Univ Technol, Sch Med, Guangdong Prov Peoples Hosp, Guangdong Acad Med Sci,Dept Cardiol, Guangzhou 510080, Peoples R China.
   [Kong, Bo; Fei, Hongwen] Guangdong Acad Med Sci, Dept Echo Room, Guangdong Prov Peoples Hosp, Guangdong Cardiovasc Inst, Guangzhou 510080, Peoples R China.
   [Ma, Huan; Guo, Lan; Bai, Bingqing; Geng, Qingshan] Guangdong Acad Med Sci, Dept Cardiol, Guangdong Cardiovasc Inst, Guangdong Prov Peoples Hosp, Guangzhou 510080, Peoples R China.
   [Jiang, Wei] Duke Univ, Med Ctr, Dept Internal Med, Dept Psychiat & Behav Sci, Durham, NC 27710 USA.
C3 Southern Medical University - China; South China University of
   Technology; Guangdong Academy of Medical Sciences & Guangdong General
   Hospital; Southern Medical University - China; Guangdong Academy of
   Medical Sciences & Guangdong General Hospital; Guangdong Academy of
   Medical Sciences & Guangdong General Hospital; Southern Medical
   University - China; Duke University
RP Geng, QS (corresponding author), Guangdong Acad Med Sci, Dept Cardiol, Guangdong Cardiovasc Inst, Guangdong Prov Peoples Hosp, Guangzhou 510080, Peoples R China.
EM gengqingshan@gdph.org.cn
RI wang, haochen/KIK-2593-2024
FU High-level Hospital Construction Project of Guangdong Provincial
   People's Hospital [DFJH201811, DFJH201922]
FX This work was supported by the High-level Hospital Construction Project
   of Guangdong Provincial People's Hospital (DFJH201811 and DFJH201922).
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NR 51
TC 3
Z9 5
U1 0
U2 10
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0301-5629
EI 1879-291X
J9 ULTRASOUND MED BIOL
JI Ultrasound Med. Biol.
PD DEC
PY 2020
VL 46
IS 12
BP 3200
EP 3209
DI 10.1016/j.ultrasmedbio.2020.07.029
PG 10
WC Acoustics; Radiology, Nuclear Medicine & Medical Imaging
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Acoustics; Radiology, Nuclear Medicine & Medical Imaging
GA OF4KN
UT WOS:000581178900003
PM 32900539
DA 2025-06-11
ER

PT J
AU de Oliveira, EP
   Moreto, F
   Silveira, LVD
   Burini, RC
AF de Oliveira, Erick Prado
   Moreto, Fernando
   de Arruda Silveira, Liciana Vaz
   Burini, Roberto Carlos
TI Dietary, anthropometric, and biochemical determinants of uric acid in
   free-living adults
SO NUTRITION JOURNAL
LA English
DT Article
DE Uric acid; Diet; Body composition; Inflammation; Metabolic syndrome
   components
ID 3RD NATIONAL-HEALTH; DENSITY-LIPOPROTEIN-CHOLESTEROL; CARDIOVASCULAR
   RISK-FACTORS; VISCERAL FAT ACCUMULATION; SKELETAL-MUSCLE MASS;
   PURINE-RICH FOODS; METABOLIC SYNDROME; OXIDATIVE STRESS; DAIRY-PRODUCTS;
   HYPERURICEMIA
AB Background: High plasma uric acid (UA) is a prerequisite for gout and is also associated with the metabolic syndrome and its components and consequently risk factors for cardiovascular diseases. Hence, the management of UA serum concentrations would be essential for the treatment and/or prevention of human diseases and, to that end, it is necessary to know what the main factors that control the uricemia increase. The aim of this study was to evaluate the main factors associated with higher uricemia values analyzing diet, body composition and biochemical markers.
   Methods: 415 both gender individuals aged 21 to 82 years who participated in a lifestyle modification project were studied. Anthropometric evaluation consisted of weight and height measurements with later BMI estimation. Waist circumference was also measured. The muscle mass (Muscle Mass Index - MMI) and fat percentage were measured by bioimpedance. Dietary intake was estimated by 24-hour recalls with later quantification of the servings on the Brazilian food pyramid and the Healthy Eating Index. Uric acid, glucose, triglycerides (TG), total cholesterol, urea, creatinine, gamma-GT, albumin and calcium and HDL-c were quantified in serum by the dry-chemistry method. LDL-c was estimated by the Friedewald equation and ultrasensitive C-reactive protein (CRP) by the immunochemiluminiscence method. Statistical analysis was performed by the SAS software package, version 9.1. Linear regression (odds ratio) was performed with a 95% confidence interval (CI) in order to observe the odds ratio for presenting UA above the last quartile (. UA > 6.5 mg/dL and. UA > 5 mg/dL). The level of significance adopted was lower than 5%.
   Results: Individuals with BMI > 25 kg/m(2) OR = 2.28(1.13-4.6) and lower MMI OR = 13.4 (5.21-34.56) showed greater chances of high UA levels even after all adjustments (gender, age, CRP, gamma-gt, LDL, creatinine, urea, albumin, HDL-c, TG, arterial hypertension and glucose). As regards biochemical markers, higher triglycerides OR = 2.76 (1.55-4.90), US-CRP OR = 2.77 (1.07-7.21) and urea OR = 2.53 (1.19-5.41) were associated with greater chances of high UA (adjusted for gender, age, BMI, waist circumference, MMI, glomerular filtration rate, and MS). No association was found between diet and UA.
   Conclusions: The main factors associated with UA increase were altered BMI (overweight and obesity), muscle hypotrophy (MMI), higher levels of urea, triglycerides, and CRP. No dietary components were found among uricemia predictors.
C1 [de Oliveira, Erick Prado; Moreto, Fernando; Burini, Roberto Carlos] UNESP, Dept Publ Hlth, Ctr Exercise Metab & Nutr CeMENutri, Botucatu Sch Med, BR-18618970 Botucatu, SP, Brazil.
   [de Oliveira, Erick Prado; Moreto, Fernando] UNESP, Botucatu Sch Med, Dept Pathol, BR-18618970 Botucatu, SP, Brazil.
   [de Arruda Silveira, Liciana Vaz] UNESP, Biosci Inst, Dept Bioestat, BR-18618970 Botucatu, SP, Brazil.
   [de Oliveira, Erick Prado] UNESP, Fac Med, Dept Saude Publ, CeMENutri, BR-18618970 Botucatu, SP, Brazil.
C3 Universidade Estadual Paulista; Universidade Estadual Paulista;
   Universidade Estadual Paulista; Universidade Estadual Paulista
RP de Oliveira, EP (corresponding author), UNESP, Dept Publ Hlth, Ctr Exercise Metab & Nutr CeMENutri, Botucatu Sch Med, BR-18618970 Botucatu, SP, Brazil.
EM erick_po@yahoo.com.br
RI de Oliveira, Erick/D-1138-2011; Moreto, Fernando/I-7690-2013; Silveira,
   Liciana/N-2244-2014
OI P. de Oliveira, Erick/0000-0001-8989-8344; Moreto,
   Fernando/0000-0002-4028-0014; Silveira, Liciana/0000-0001-8931-5495
FU CNPq; CAPES; FAPESP
FX CNPq, CAPES and FAPESP for the financial support and GAP (a statistical
   support of Botucatu School of Medicine) for the statistical analysis.
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NR 70
TC 32
Z9 32
U1 0
U2 16
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1475-2891
J9 NUTR J
JI Nutr. J.
PD JAN 12
PY 2013
VL 12
AR 11
DI 10.1186/1475-2891-12-11
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 096DG
UT WOS:000315383600001
PM 23311699
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Luczaj, W
   Gegotek, A
   Skrzydlewska, E
AF Luczaj, Wojciech
   Gegotek, Agnieszka
   Skrzydlewska, Elzbieta
TI Analytical approaches to assess metabolic changes in psoriasis
SO JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
LA English
DT Review
DE Proteomics; Lipidomics; Psoriasis; MS based analysis; Samples
   preparation; Signaling pathways
ID SPECTROMETRY-BASED PROTEOMICS; SKIN BARRIER FUNCTION; CD8(+) T-CELLS;
   MASS-SPECTROMETRY; OXIDATIVE STRESS; STRATUM-CORNEUM; ATOPIC-DERMATITIS;
   REMOVE ALBUMIN; BIOMARKERS; SERUM
AB Psoriasis is one of the most common human skin diseases, although its development is not limited to one tissue, but is associated with autoimmune reactions throughout the body. Overproduction of pro-in-flammatory cytokines and growth factors systemically stimulates the proliferation of skin cells, which manifests as excessive exfoliation of the epidermis, and/or arthritis, as well as other comorbidities such as insulin resistance, metabolic syndrome, hypertension, and depression. Thus, there is a great need for a thorough analysis of the pathophysiology of psoriatic patients, including classical methods, such as spec-trophotometry, chromatography, or Western blot, and also novel omics approaches such as lipidomics and proteomics. Moreover, the extensive pathophysiology forces increased research examining biological changes in both skin cells, and systemically. A wide range of techniques involved in lipidomic research based on a combination of mass spectrometry and different types of chromatography (RP-LC-QTOF-MS/MS, HILIC-QTOF-MS/MS or RP-LC-QTRAP-MS/MS), have allowed comprehensive assessment of lipid modifica-tion in psoriatic skin and provided new insight into the role of lipids and their mechanism of action in psoriasis. Moreover, proteomic analysis using gel-nanoLC-OrbiTrap-MS/MS, as well as MALDI-TOF/TOF techniques facilitates the description of panels of enzymes involved in lipidome modifications, and the response of the endocannabinoid system to metabolic changes. Psoriasis is known to alter the expression of proteins that are involved in the inflammatory and antioxidant response, as well as protein biosynthesis, degradation, as well as cell proliferation and apoptosis. Knowledge of changes in the lipidomic and pro-teomic profile will not only allow the understanding of psoriasis pathophysiology, but also facilitate proper and early diagnosis and effective pharmacotherapy. (c) 2021 Elsevier B.V. All rights reserved.
C1 [Luczaj, Wojciech; Gegotek, Agnieszka; Skrzydlewska, Elzbieta] Med Univ Bialystok, Dept Analyt Chem, Mickiewicza 2d, PL-15222 Bialystok, Poland.
C3 Medical University of Bialystok
RP Skrzydlewska, E (corresponding author), Med Univ Bialystok, Dept Analyt Chem, Mickiewicza 2d, PL-15222 Bialystok, Poland.
EM elzbieta.skrzydlewska@umb.edu.pl
RI Gęgotek, Agnieszka/GVU-1667-2022; Łuczaj, Wojciech/S-1337-2018
OI Gegotek, Agnieszka/0000-0002-5240-1346
FU National Science Centre, Poland (NCN) [2016/23/B/NZ7/02350]
FX This study was financed by the National Science Centre, Poland (NCN)
   (2016/23/B/NZ7/02350) .
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NR 184
TC 10
Z9 10
U1 1
U2 17
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0731-7085
EI 1873-264X
J9 J PHARMACEUT BIOMED
JI J. Pharm. Biomed. Anal.
PD OCT 25
PY 2021
VL 205
AR 114359
DI 10.1016/j.jpba.2021.114359
EA SEP 2021
PG 18
WC Chemistry, Analytical; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Pharmacology & Pharmacy
GA UX1DI
UT WOS:000700587300011
PM 34509137
DA 2025-06-11
ER

PT J
AU Xu, YL
   Wei, Y
   Long, TF
   Wang, RX
   Li, ZY
   Yu, CZ
   Wu, TC
   He, MA
AF Xu, Yali
   Wei, Yue
   Long, Tengfei
   Wang, Ruixin
   Li, Zhaoyang
   Yu, Caizheng
   Wu, Tangchun
   He, Meian
TI Association between urinary metals levels and metabolic phenotypes in
   overweight and obese individuals
SO CHEMOSPHERE
LA English
DT Article
DE Metal; Urine; Obesity; Metabolic phenotype; Metabolic syndrome
ID KOREA NATIONAL-HEALTH; BODY-MASS INDEX; DIABETES-MELLITUS;
   BLOOD-PRESSURE; OXIDATIVE STRESS; SERUM SELENIUM; CHINESE ADULTS; US
   POPULATION; NORMAL-WEIGHT; ZINC LEVELS
AB Epidemiologic studies suggest that circulating metals from the natural environment are linked with cardiometabolic health. However, few studies examined the relationship between multiple metals exposure and metabolic phenotypes, especially in obese individuals. We conducted a cross-sectional study to explore the association between 23 urinary metals and metabolic phenotypes in 1392 overweight and obese individuals (592 males, 800 females, mean age 43.1 +/- 9.8 years). Participants were classified as metabolically unhealthy if they had >= 2 of the following metabolic abnormalities: elevated blood pressure, elevated fasting blood glucose, elevated triglycerides, and reduced high-density lipoprotein cholesterol. Odds ratios (ORs) of unhealthy metabolic phenotypes for metal levels categorized into tertiles were assessed using logistic regression models. Five metals (barium, copper, iron, uranium, and zinc) were associated with unhealthy metabolic phenotypes in single-metal models, while in the multiple-metal model, only zinc and zinc-copper ratio remained significant. The ORs (95% CIs) comparing extreme tertiles were 2.57 (1.69, 3.89) for zinc and 1.68 (1.24, 2.27) for zinc-copper ratio after adjustment for confounders (both p-trends were <0.001). The numbers of metabolic abnormalities significantly increased with the levels of zinc and the zinc-copper ratio increased. Similar associations were observed with metabolic syndrome risk. High levels of urinary zinc were positively associated with elevated fasting blood glucose (p-trend < 0.001) and elevated triglycerides (p-trend = 0.003). The results suggest that urinary zinc and zinc-copper ratio are positively associated with increased risk of unhealthy metabolic phenotype. Further prospective studies with a larger sample size are required to verify these findings. (C) 2020 Elsevier Ltd. All rights reserved.
C1 [Xu, Yali; Wei, Yue; Long, Tengfei; Wang, Ruixin; Li, Zhaoyang; Yu, Caizheng; Wu, Tangchun; He, Meian] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Dept Occupat & Environm Hlth, 13 Hangkong Rd, Wuhan 430030, Hubei, Peoples R China.
   [Xu, Yali; Wei, Yue; Long, Tengfei; Wang, Ruixin; Li, Zhaoyang; Yu, Caizheng; Wu, Tangchun; He, Meian] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, State Key Lab Environm Hlth Incubating, 13 Hangkong Rd, Wuhan 430030, Hubei, Peoples R China.
   [Yu, Caizheng] Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Dept Publ Hlth, Wuhan, Peoples R China.
C3 Huazhong University of Science & Technology; Huazhong University of
   Science & Technology; Huazhong University of Science & Technology
RP He, MA (corresponding author), Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Dept Occupat & Environm Hlth, 13 Hangkong Rd, Wuhan 430030, Hubei, Peoples R China.
EM hemeian@hotmail.com
RI Wang, ruixin/KTI-1761-2024; Yu, Caizheng/AAQ-9031-2021; Zhang,
   Yuting/JZE-2800-2024; Wei, Yue/HPG-0214-2023
FU National Natural Science Foundation [NSFC-81522040, 81473051]; National
   Key R&D Program of China [2017YFC0907501, 2016YF0900800]; Program for
   HUST Academic Frontier Youth Team
FX This work was supported by the National Natural Science Foundation
   (grant NSFC-81522040 and 81473051), the National Key R&D Program of
   China (2017YFC0907501 and 2016YF0900800), and the Program for HUST
   Academic Frontier Youth Team for Meian He.
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NR 65
TC 16
Z9 17
U1 0
U2 15
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0045-6535
EI 1879-1298
J9 CHEMOSPHERE
JI Chemosphere
PD SEP
PY 2020
VL 254
AR 126763
DI 10.1016/j.chemosphere.2020.126763
PG 10
WC Environmental Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology
GA LV0RC
UT WOS:000538150400025
PM 32957263
DA 2025-06-11
ER

PT J
AU Pons, Z
   Margalef, M
   Bravo, FI
   Arola-Arnal, A
   Muguerza, B
AF Pons, Zara
   Margalef, Maria
   Bravo, Francisca I.
   Arola-Arnal, Anna
   Muguerza, Begona
TI Acute administration of single oral dose of grape seed polyphenols
   restores blood pressure in a rat model of metabolic syndrome: role of
   nitric oxide and prostacyclin
SO EUROPEAN JOURNAL OF NUTRITION
LA English
DT Article
DE Cafeteria diet; Hypertension; Antihypertensive agent;
   Endothelial-relaxing factors
ID RICH COCOA POWDER; CAFETERIA DIET; OXIDATIVE STRESS; EUROPEAN-SOCIETY;
   HYPERTENSION; EXTRACT; INHIBITION; OBESITY
AB The aims of this study were to evaluate the antihypertensive effectiveness of different doses of grape seed polyphenols in cafeteria diet-fed hypertensive rats (CHRs) and to establish the mechanism involved in the blood pressure (BP) lowering effect of these compounds in this experimental model of metabolic syndrome (MS).
   Male 8-week-old Wistar rats were fed cafeteria or standard (ST) diet for 10 weeks. After this, the antihypertensive effect of a single oral administration of a polyphenol grape seed extract (GSPE) was tested at different doses (250, 375 and 500 mg/kg) in CHRs. BP was recorded before and 2, 4, 6, 8, 24 and 48 h post-administration. The hypotensive effect of GSPE was also proved in ST diet-fed rats. Additionally, in other experiment, CHRs were orally administered 375 mg/kg GSPE. Four hours post-administration, the rats were intraperitoneally administrated 30 mg/kg NG-nitro-l-arginine methyl ester (l-NAME) or 5 mg/kg indomethacin [inhibitors of nitric oxide (NO) and prostacyclin synthesis, respectively]. BP was recorded initially and 6 h post-administration.
   GSPE produced a decrease in SBP and DBP, the most effective dose (375 mg/kg) showing an antihypertensive effect in CHRs similar to the drug captopril, and did not affect BP of ST diet-fed rats. The antihypertensive effect was completely abolished by l-NAME and partially inhibited by indomethacin.
   GSPE acts as an antihypertensive agent in a rat model of hypertension associated with MS. The change in endothelium-derived NO availability is one of the mechanisms involved in the antihypertensive effect of GSPE in CHRs. Additionally, endothelial prostacyclin contributes to the effect of GSPE on arterial BP.
C1 [Pons, Zara; Margalef, Maria; Bravo, Francisca I.; Arola-Arnal, Anna; Muguerza, Begona] Univ Rovira & Virgili, Nutrigen Res Grp, Dept Biochem & Biotechnol, E-43007 Tarragona, Spain.
   [Muguerza, Begona] CEICS, TECNIO, Ctr Tecnol Nutr & Salut, Tarragona, Spain.
C3 Universitat Rovira i Virgili
RP Arola-Arnal, A (corresponding author), Univ Rovira & Virgili, Nutrigen Res Grp, Dept Biochem & Biotechnol, E-43007 Tarragona, Spain.
EM anna.arola@urv.cat
RI Muguerza, Begoña/AAT-3544-2021; Bravo, Francisca/L-4409-2019; Muguerza,
   Begona/C-6704-2015; Arola-Arnal, Anna/C-2087-2015; Margalef,
   Maria/E-9501-2018
OI Bravo, Francisca Isabel/0000-0002-6468-3088; Muguerza,
   Begona/0000-0001-7384-8588; Pons Vila, Zara/0000-0003-0122-2556;
   Arola-Arnal, Anna/0000-0001-6529-1345; Margalef,
   Maria/0000-0001-7932-9770
FU Spanish Government [AGL2013-40707-RI]
FX This work has been supported by Grant No. AGL2013-40707-RI from the
   Spanish Government. We want to thank Niuka Llopiz, Rosa Pastor and Yaiza
   Tobajas for their technical support and to Matthew Cox for the language
   revision of the article.
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NR 35
TC 36
Z9 39
U1 0
U2 27
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1436-6207
EI 1436-6215
J9 EUR J NUTR
JI Eur. J. Nutr.
PD MAR
PY 2016
VL 55
IS 2
BP 749
EP 758
DI 10.1007/s00394-015-0895-0
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA DF3RD
UT WOS:000371262400029
PM 25862540
DA 2025-06-11
ER

PT J
AU Koloverou, E
   Panagiotakos, DB
   Pitsavos, C
   Chrysohoou, C
   Georgousopoulou, EN
   Metaxa, V
   Stefanadis, C
AF Koloverou, E.
   Panagiotakos, D. B.
   Pitsavos, C.
   Chrysohoou, C.
   Georgousopoulou, E. N.
   Metaxa, V.
   Stefanadis, C.
CA ATTICA Study Grp
TI Effects of alcohol consumption and the metabolic syndrome on 10-year
   incidence of diabetes: The ATTICA study
SO DIABETES & METABOLISM
LA English
DT Article
DE Diabetes; Incidence; Alcohol consumption; Drinking; Ethanol
ID CARDIOVASCULAR-DISEASE; INSULIN SENSITIVITY; OXIDATIVE STRESS; RED WINE;
   RISK; MELLITUS; DRINKING; JAPANESE; ASSOCIATIONS; MANAGEMENT
AB Aim. - The purpose of this prospective study was to investigate the effect of alcohol consumption on the 10-year diabetes incidence.
   Methods. - In 2001-2002, a random sample of 1514 men (18-89 years old) and 1528 women (18-87 years old) was selected to participate in the ATTICA study (Athens metropolitan area, Greece). Among various other characteristics, average daily alcohol intakes (abstention, low, moderate, high) and type of alcoholic drink were evaluated. Diabetes was defined according to American Diabetes Association criteria. During 2011-2012, the 10-year follow-up was performed.
   Results. - The 10-year incidence of diabetes was 13.4% in men and 12.4% in women. After making various adjustments, those who consumed up to 1 glass/day of alcohol had a 53% lower diabetes risk (RR= 0.47; 95% CI: 0.26, 0.83) compared with abstainers, while trend analysis revealed a significant U-shaped relationship between quantity of alcohol drunk and diabetes incidence (P <0.001 for trend). Specific types of drinks were not associated with diabetes incidence; however, a one-unit increase in ratio of wine/beer/vodka vs. other spirits was associated with an 89% lower risk of diabetes (RR = 0.11; 95% CI: 0.02, 0.67). The protective effect of low alcohol consumption on diabetes incidence was more prominent among individuals with stricter adherence to the Mediterranean diet (RR = 0.08; 95% CI: 0.011, 0.70) and without the metabolic syndrome (RR= 0.34; 95% CI: 0.16, 0.70).
   Conclusion. - This work revealed the protective effect of modest alcohol consumption of particularly wine and beer against the long-term incidence of diabetes, possibly due to their pleiotropic health effects. (c) 2014 Elsevier Masson SAS. All rights reserved.
C1 [Koloverou, E.; Panagiotakos, D. B.; Georgousopoulou, E. N.] Harokopio Univ, Sch Hlth Sci & Educ, Dept Nutr & Dietet, Athens, Greece.
   [Pitsavos, C.; Chrysohoou, C.; Metaxa, V.; Stefanadis, C.] Univ Athens, Sch Med, Cardiol Clin 1, GR-11527 Athens, Greece.
C3 Harokopio University Athens; National & Kapodistrian University of
   Athens; Athens Medical School
RP Panagiotakos, DB (corresponding author), 46 Paleon Polemiston St Glyfada, Attica 16674, Greece.
EM d.b.panagiotakos@usa.net
RI Panagiotakos, Demosthenes/K-8294-2019; Georgousopoulou,
   Ekavi/AAC-2563-2019; Stefanadis, Christodoulos/ABH-2232-2020;
   papadimitriou, lampros/I-3316-2013
OI Stefanadis, Christodoulos/0000-0001-5974-6454; papadimitriou,
   lampros/0000-0003-3356-0963; Chrysohoou, Christina/0000-0002-6340-3996
FU Coca-Cola SA
FX Demosthenes Panagiotakos and Ekavi Georgousopoulou received research
   grants from Coca-Cola SA (10.9.2013).
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NR 38
TC 26
Z9 30
U1 0
U2 24
PU MASSON EDITEUR
PI MOULINEAUX CEDEX 9
PA 21 STREET CAMILLE DESMOULINS, ISSY, 92789 MOULINEAUX CEDEX 9, FRANCE
SN 1262-3636
EI 1878-1780
J9 DIABETES METAB
JI Diabetes Metab.
PD APR
PY 2015
VL 41
IS 2
BP 152
EP 159
DI 10.1016/j.diabet.2014.06.003
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA CI2PY
UT WOS:000354590700008
PM 25190450
DA 2025-06-11
ER

PT J
AU Marcus, Y
   Shefer, G
   Sasson, K
   Kohen, F
   Limor, R
   Pappo, O
   Nevo, N
   Biton, I
   Bach, M
   Berkutzki, T
   Fridkin, M
   Benayahu, D
   Shechter, Y
   Stern, N
AF Marcus, Yonit
   Shefer, Gabi
   Sasson, Keren
   Kohen, Fortune
   Limor, Rona
   Pappo, Orit
   Nevo, Nava
   Biton, Inbal
   Bach, Michal
   Berkutzki, Tamara
   Fridkin, Matityahu
   Benayahu, Dafna
   Shechter, Yoram
   Stern, Naftali
TI Angiotensin 1-7 as Means to Prevent the Metabolic Syndrome Lessons From
   the Fructose-Fed Rat Model
SO DIABETES
LA English
DT Article
ID NADPH OXIDASE ACTIVATION; OBESE ZUCKER RATS; RENIN-ANGIOTENSIN;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; HEPATIC STEATOSIS; ADIPOSE-TISSUE;
   MACROPHAGE INFILTRATION; VASCULAR DYSFUNCTION; KALLIKREIN-KININ
AB We studied the effects of chronic angiotensin 1-7 (Ang 1-7) treatment in an experimental model of the metabolic syndrome, i.e., rats given high-fructose/low-magnesium diet (HFrD). Rats were fed on HFrD for 24 weeks with and without Ang 1-7 (576 mu g/kg/day, s.c., Alzet pumps). After 6 months, Ang 1-7 treated animals had lower body weight (-9.5%), total fat mass (detected by magnetic resonance imaging), and serum triglycerides (-51%), improved glucose tolerance, and better insulin sensitivity. Similar metabolic effects were also evident, albeit in the absence of weight loss, in rats first exposed to HFrD for 5 months and then subjected to short-term (4 weeks) treatment with Ang 1-7. Six months of Ang 1-7 treatment were associated with lower plasma renin activity (-40%) and serum aldosterone (-48%), less hepatosteatatitis, and a reduction in epididymal adipocyte volume. The marked attenuation of macrophage infiltration in white adipose tissue (WAT) was associated with reduced levels of the pP65 protein in the epididymal fat tissue, suggesting less activation of the nuclear factor-kappa B (NF kappa B) pathway in Ang 1-7-treated rats. WAT from Ang 1-7-treated rats showed reduced NADPH-stimulated superoxide production. In single muscle fibers (myofibers) harvested and grown ex vivo for 10 days, myofibers from HFrD rats gave rise to 20% less myogenic cells than the Ang 1-7-treated rats. Fully developed adipocytes were present in most HFrD myofiber cultures but entirely absent in cultures from Ang 1-7-treated rats. In summary, Ang 1-7 had an ameliorating effect on insulin resistance, hypertriglyceridemia, fatty liver, obesity, adipositis, and myogenic and adipogenic differentiation in muscle tissue in the HFrD rats. Diabetes 62:1121-1130, 2013
C1 [Marcus, Yonit; Sasson, Keren; Shechter, Yoram] Weizmann Inst Sci, Dept Biol Chem, IL-76100 Rehovot, Israel.
   [Marcus, Yonit; Shefer, Gabi; Limor, Rona; Bach, Michal; Stern, Naftali] Tel Aviv Univ, Tel Aviv Sourasky Med Ctr, Inst Endocrinol Metab & Hypertens, IL-69978 Tel Aviv, Israel.
   [Shefer, Gabi; Benayahu, Dafna; Stern, Naftali] Tel Aviv Univ, Sackler Fac Med, IL-69978 Tel Aviv, Israel.
   [Kohen, Fortune; Nevo, Nava] Weizmann Inst Sci, Dept Biol Regulat, IL-76100 Rehovot, Israel.
   [Pappo, Orit] Hadassah Hebrew Univ, Med Ctr, Dept Pathol, Jerusalem, Israel.
   [Biton, Inbal; Berkutzki, Tamara] Weizmann Inst Sci, Dept Vet Resources, IL-76100 Rehovot, Israel.
   [Fridkin, Matityahu] Weizmann Inst Sci, Dept Organ Chem, IL-76100 Rehovot, Israel.
C3 Weizmann Institute of Science; Tel Aviv University; Sackler Faculty of
   Medicine; Tel Aviv Sourasky Medical Center; Tel Aviv University; Sackler
   Faculty of Medicine; Weizmann Institute of Science; Hebrew University of
   Jerusalem; Hadassah University Medical Center; Weizmann Institute of
   Science; Weizmann Institute of Science
RP Stern, N (corresponding author), Tel Aviv Univ, Tel Aviv Sourasky Med Ctr, Inst Endocrinol Metab & Hypertens, IL-69978 Tel Aviv, Israel.
EM stern@tasmc.health.gov.il
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NR 50
TC 61
Z9 68
U1 0
U2 16
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0012-1797
J9 DIABETES
JI Diabetes
PD APR
PY 2013
VL 62
IS 4
BP 1121
EP 1130
DI 10.2337/db12-0792
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 111MS
UT WOS:000316526000022
PM 23250359
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Jalili, C
   Moradi, S
   Mirzababaei, A
   Mohammadi, H
   Heydarzadeh, F
   Miraghajani, M
   Lazaridi, AV
AF Jalili, Cyrus
   Moradi, Sajjad
   Mirzababaei, Atieh
   Mohammadi, Hamed
   Heydarzadeh, Fatima
   Miraghajani, Maryam
   Lazaridi, Anastasia-Viktoria
TI Effects of Anethum graveolens (dill) and its derivatives
   on controlling cardiovascular risk factors: A systematic review and
   meta-analysis
SO JOURNAL OF HERBAL MEDICINE
LA English
DT Review
DE Anethum graveolens; Dill; Metabolic indices; Systematic review;
   Meta-analysis
ID SOY MILK CONSUMPTION; OXIDATIVE STRESS; METABOLIC SYNDROME; HERBAL
   MEDICINES; D DEFICIENCY; L.; SUPPLEMENTATION; EXTRACTS; PROFILE; PLANTS
AB Objective: Previous studies have demonstrated that the supplementation of Anethum graveolens (dill) could affect the metabolic indices. Thus, the present study summarizes all of the published clinical studies which evaluate the efficacy of dill administration on cardiovascular risk factors. Methods: The clinical trials were found using Scopus, Embase, PubMed and ISI Web of Science databases; these were searched to infinity until August 2020. Mean differences (MD) were pooled using a random-effects model. Publication bias, sensitivity analysis, and heterogeneity were assessed using standard methods. Results: Results demonstrated that the administration of dill and its derivatives, led to a significant change in the fasting insulin (WMD: -2.34 mg/dl; 95% CI: -3.70, -0.99; P = 0.001), HOMA-IR (WMD: -1.07; 95% CI: -1.96, -0.17; P = 0.019), and LDL serum levels (WMD: -9.36 mg/dl; 95% CI: -14.45, -4.27; P < 0.001), unlike fasting blood sugar (P = 0.501), weight (P = 0.650), body mass index (P = 0.846), HDL (P = 0.813), TG (P = 0.385) or TC concentration (P = 0.075). Subgroup analysis indicated that dill administration significantly reduce LDL levels in eight and more than eight weeks of intervention, in dill extract intervention versus powder form, and in cases of type 2 diabetes mellitus versus hyperlipidemia or metabolic syndrome patients. Another subgroup analysis revealed that dill supplementation significantly decreased TG concentrations in > 8 weeks of treatment in overweight rather than obese individuals. In the same results, a subgroup analysis showed that dill administration significantly decreased TC levels in > 8 weeks of treatment in overweight individuals but not in other populations. Conclusion: Dill administration significantly reduces fasting insulin, HOMA-IR, and LDL levels.
C1 [Jalili, Cyrus] Kermanshah Univ Med Sci, Med Biol Res Ctr, Hlth Technol Inst, Kermanshah, Iran.
   [Moradi, Sajjad] Kermanshah Univ Med Sci, Sch Nutr Sci & Food Technol, Nutr Sci Dept, Kermanshah, Iran.
   [Mirzababaei, Atieh; Heydarzadeh, Fatima] Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Community Nutr, Tehran, Iran.
   [Mohammadi, Hamed] TehranUniv Med Sci, Sch Nutr Sci & Dietet, Dept Clin Nutr, Tehran, Iran.
   [Miraghajani, Maryam] Shahid Beheshti Univ Med Sci, Canc Res Ctr, Tehran, Iran.
   [Miraghajani, Maryam; Lazaridi, Anastasia-Viktoria] Univ Nottingham, Acad Div Child Hlth Obstet & Gynaecol, Early Life Res Unit, Nottingham NG7 2UH, England.
   [Miraghajani, Maryam; Lazaridi, Anastasia-Viktoria] Univ Nottingham, Nottingham Digest Dis Ctr, Nottingham NG7 2UH, England.
   [Miraghajani, Maryam; Lazaridi, Anastasia-Viktoria] Univ Nottingham, Biomed Res Ctr, Sch Med, Nottingham NG7 2UH, England.
C3 Kermanshah University of Medical Sciences; Kermanshah University of
   Medical Sciences; Tehran University of Medical Sciences; Shahid Beheshti
   University Medical Sciences; University of Nottingham; University of
   Nottingham; University of Nottingham
RP Moradi, S (corresponding author), Kermanshah Univ Med Sci, Sch Nutr Sci & Food Technol, Nutr Sci Dept, Kermanshah, Iran.; Miraghajani, M (corresponding author), Shahid Beheshti Univ Med Sci, Canc Res Ctr, Tehran, Iran.
EM sajadmoradi9096@gmail.com; Maryam.sadatmiraghajani@nottingham.ac.uk
RI Mirzababaee, Atieh/AAQ-7191-2020; Jalili, Cyrus/K-9663-2019; Mohammadi,
   Hamed/Q-3166-2019; Moradi, Sajjad/AAX-7317-2020
OI Miraghajani, Maryam/0000-0002-8265-0335
FU Kermanshah University of Medical Sciences [991014]
FX This study was supported by a research grants from Kermanshah University
   of Medical Sciences (Grant ID: 991014).
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NR 57
TC 3
Z9 3
U1 0
U2 6
PU ELSEVIER GMBH
PI MUNICH
PA HACKERBRUCKE 6, 80335 MUNICH, GERMANY
SN 2210-8033
EI 2210-8041
J9 J HERB MED
JI J. Herb. Med.
PD DEC
PY 2021
VL 30
AR 100516
DI 10.1016/j.hermed.2021.100516
EA OCT 2021
PG 10
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA WS2VB
UT WOS:000715043800002
DA 2025-06-11
ER

PT J
AU Montez, P
   Vázquez-Medina, JP
   Rodríguez, R
   Thorwald, MA
   Viscarra, JA
   Lam, L
   Peti-Peterdi, J
   Nakano, D
   Nishiyama, A
   Ortiz, RM
AF Montez, Priscilla
   Vazquez-Medina, Jose Pablo
   Rodriguez, Ruben
   Thorwald, Max A.
   Viscarra, Jose A.
   Lam, Lisa
   Peti-Peterdi, Janos
   Nakano, Daisuke
   Nishiyama, Akira
   Ortiz, Rudy M.
TI Angiotensin Receptor Blockade Recovers Hepatic UCP2 Expression and
   Aconitase and SDH Activities and Ameliorates Hepatic Oxidative Damage in
   Insulin Resistant Rats
SO ENDOCRINOLOGY
LA English
DT Article
ID MITOCHONDRIAL UNCOUPLING PROTEIN-2; SKELETAL-MUSCLE MITOCHONDRIA; OXYGEN
   SPECIES PRODUCTION; FATTY LIVER-DISEASE; METABOLIC-SYNDROME;
   NONALCOHOLIC STEATOHEPATITIS; DIABETIC COMPLICATIONS;
   GLUCOSE-INTOLERANCE; TELMISARTAN THERAPY; HUMAN HYPERTENSION
AB Metabolic syndrome (MetS) is commonly associated with elevated renin-angiotensin system, oxidative stress, and steatohepatitis with down-regulation of uncoupling proteins (UCPs). However, the mechanisms linking renin-angiotensin system, steatosis, and UCP2 to hepatic oxidative damage during insulin resistance are not described. To test the hypothesis that angiotensin receptor activation contributes to decreased hepatic UCP2 expression and aconitase activity and to increased oxidative damage after increased glucose intake in a model of MetS, lean and obese Long Evans rats (n = 10/group) were randomly assigned to the following groups: 1) untreated Long Evans Tokushima Otsuka (lean, strain control), 2) untreated Otsuka Long Evans Tokushima Fatty (OLETF) (MetS model), 3) OLETF + angiotensin receptor blocker (ARB) (10 mg olmesartan/kg.d x 6 wk), 4) OLETF + high glucose (HG) (5% in drinking water x 6 wk), and 5) OLETF + ARB + HG (ARB/HG x 6 wk). HG increased body mass (37%), plasma triglycerides (TGs) (35%), plasma glycerol (87%), plasma free fatty acids (28%), and hepatic nitrotyrosine (74%). ARB treatment in HG decreased body mass (12%), plasma TG (15%), plasma glycerol (23%), plasma free fatty acids (14%), and hepatic TG content (42%), suggesting that angiotensin receptor type 1 (AT1) activation and increased adiposity contribute to the development of obesity-related dyslipidemia. ARB in HG also decreased hepatic nitrotyrosine and increased hepatic UCP2 expression (59%) and aconitase activity (40%), as well as antioxidant enzyme activities (50-120%), suggesting that AT1 activation also contributes to protein oxidation, impaired lipid metabolism, and antioxidant metabolism in the liver. Thus, in addition to promoting obesity-related hypertension, AT1 activation may also impair lipid metabolism and antioxidant capacity, resulting in steatosis via decreased UCP2 and tricarboxylic acid cycle activity. (Endocrinology 153: 5746-5759, 2012)
C1 [Ortiz, Rudy M.] Univ Calif, Dept Mol & Cellular Biol, Sch Nat Sci, Merced, CA 95343 USA.
   [Lam, Lisa; Peti-Peterdi, Janos] Univ So Calif, Keck Sch Med, Dept Physiol & Biophys, Los Angeles, CA 90089 USA.
   [Nakano, Daisuke; Nishiyama, Akira] Kagawa Med Univ, Dept Pharmacol, Kagawa 7610793, Japan.
C3 University of California System; University of California Merced;
   University of Southern California; Kagawa University
RP Ortiz, RM (corresponding author), Univ Calif, Dept Mol & Cellular Biol, Sch Nat Sci, 5200 N Lake Rd, Merced, CA 95343 USA.
EM rortiz@ucmerced.edu
RI Vazquez-Medina, Jose/AAH-8432-2020; NAKANO, DAISUKE/JWP-5663-2024
OI Rodriguez, Ruben/0009-0006-5222-7145; Thorwald, Max/0000-0003-0095-5344;
   Viscarra, Jose/0000-0003-1273-4098; Nishiyama,
   Akira/0000-0001-5971-820X; Vazquez-Medina, Jose
   Pablo/0000-0003-1014-5214; Rodriguez, Ruben/0000-0001-8174-2556
FU National Institutes of Health (NIH) National Institute on Minority
   Health and Health Disparities [1P20MD005049-01]; NIH National Center on
   Minority Health and Health Disparities [9T37MD001480]; NIH National
   Heart, Lung, and Blood Institute (NHLBI) [K02HL103787]; American
   Diabetes Association [1-11-BS-121]; NIH NCMHD [9T37MD001480]; NIH NHLBI
   [R01HL091767]
FX P.M. was supported by National Institutes of Health (NIH) National
   Institute on Minority Health and Health Disparities Grant
   1P20MD005049-01; R. R. and J.A.V. were supported by NIH National Center
   on Minority Health and Health Disparities Grant 9T37MD001480; and R.M.O.
   was partially supported by NIH National Heart, Lung, and Blood Institute
   (NHLBI) Grant K02HL103787. Research was supported by American Diabetes
   Association Grant 1-11-BS-121 (to J.P.-P.) and NIH NCMHD grant
   9T37MD001480, and NIH NHLBI Grant R01HL091767 (to R.M.O.).
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NR 78
TC 22
Z9 31
U1 0
U2 18
PU ENDOCRINE SOC
PI CHEVY CHASE
PA 8401 CONNECTICUT AVE, SUITE 900, CHEVY CHASE, MD 20815-5817 USA
SN 0013-7227
J9 ENDOCRINOLOGY
JI Endocrinology
PD DEC
PY 2012
VL 153
IS 12
BP 5746
EP 5759
DI 10.1210/en.2012-1390
PG 14
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 046GA
UT WOS:000311752300008
PM 23087176
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Bass, A
   Hinderliter, AL
   Lee, CR
AF Bass, Almasa
   Hinderliter, Alan L.
   Lee, Craig R.
TI The Impact of Ezetimibe on Endothelial Function and Other Markers of
   Cardiovascular Risk
SO ANNALS OF PHARMACOTHERAPY
LA English
DT Article
DE endothelial function; ezetimibe; flow-mediated dilation; inflammation;
   pleiotropic; statins
ID METABOLIC-SYNDROME; SIMVASTATIN MONOTHERAPY; ARTERIAL STIFFNESS;
   STATINS; ATHEROSCLEROSIS; INFLAMMATION; DEFICIENT; LDL; COMBINATION;
   REDUCTION
AB OBJECTIVE: To review the published literature characterizing the impact of ezetimibe-containing lipid-lowering regimens on endothelial function and other markers of cardiovascular risk and discuss the potential relevance of these effects to the clinical benefit of ezetimibe.
   DATA SOURCES: A MEDLINE search (2000-August 2009) was completed using the key words ezetimibe, statins, endothelial function, flow-mediated dilation, pleiotropic, and inflammation to identify relevant literature. Bibliographies of identified literature were reviewed for additional references.
   STUDY SELECTION AND DATA EXTRACTION: All clinical studies published in English that evaluated the effect of ezetimibe on ancillary endpoints of cardiovascular disease risk, including endothelial function, inflammation, thrombosis, and oxidative stress, were evaluated.
   DATA SYNTHESIS: Recent studies in patients with coronary artery disease (CAD), heart failure, and hypercholesterolemia have demonstrated that treatment with ezetimibe for 4-12 weeks elicits no improvement of endothelial function or other measures of cardiovascular disease risk. In contrast, other studies have reported that ezetimibe improves endothelial function in certain patient populations, including those with rheumatoid arthritis, CAD with type 2 diabetes, and metabolic syndrome. However, the statin monotherapy comparator groups in these studies that yielded equivalent reductions in cholesterol were superior, or at least equivalent to, ezetimibe-containing regimens in the improvement of these ancillary endpoints.
   CONCLUSIONS: Overall, the evidence to date suggests that administration of ezetimibe, either as monotherapy or in combination with a statin, exerts minimal beneficial effects on endothelial function and other ancillary measures of cardiovascular disease risk beyond those conferred by its cholesterol-lowering effects. Studies with larger sample sizes and follow-up beyond 12 weeks remain necessary to further define the impact of ezetimibe on the processes integral to the pathogenesis and progression of cardiovascular disease.
C1 [Lee, Craig R.] Univ N Carolina, Eshelman Sch Pharm, Div Pharmacotherapy & Expt Therapeut, Chapel Hill, NC 27599 USA.
   [Hinderliter, Alan L.] Univ N Carolina, Sch Med, Div Cardiol, Chapel Hill, NC 27599 USA.
C3 University of North Carolina; University of North Carolina Chapel Hill;
   University of North Carolina; University of North Carolina Chapel Hill;
   University of North Carolina School of Medicine
RP Lee, CR (corresponding author), Univ N Carolina, Eshelman Sch Pharm, Div Pharmacotherapy & Expt Therapeut, 2317 Kerr Hall,CB 7569, Chapel Hill, NC 27599 USA.
EM craig_lee@unc.edu
OI Lee, Craig/0000-0003-3595-5301
FU American Heart Association
FX This work was supported by an award from the American Heart Association
   to Dr. Lee.
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NR 41
TC 14
Z9 15
U1 0
U2 4
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1060-0280
EI 1542-6270
J9 ANN PHARMACOTHER
JI Ann. Pharmacother.
PD DEC
PY 2009
VL 43
IS 12
BP 2021
EP 2030
DI 10.1345/aph.1M302
PG 10
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 531EC
UT WOS:000272644700011
PM 19920161
DA 2025-06-11
ER

PT J
AU Businaro, R
   Corsi, M
   Asprino, R
   Di Lorenzo, C
   Laskin, D
   Corbo, RM
   Ricci, S
   Pinto, A
AF Businaro, R.
   Corsi, M.
   Asprino, R.
   Di Lorenzo, C.
   Laskin, D.
   Corbo, R. M.
   Ricci, S.
   Pinto, A.
TI Modulation of Inflammation as a Way of Delaying Alzheimer's Disease
   Progression: The Diet's Role
SO CURRENT ALZHEIMER RESEARCH
LA English
DT Review
DE Alzheimer's disease; nutrition inflammation; cytokines; polyphenols;
   fatty acids; central nervous system
ID NF-KAPPA-B; CARDIOVASCULAR RISK-FACTORS; MILD COGNITIVE IMPAIRMENT;
   CENTRAL-NERVOUS-SYSTEM; LOW-GRADE INFLAMMATION; AMYLOID BETA-PROTEIN;
   BLOOD-BRAIN-BARRIER; MEDITERRANEAN DIET; DOCOSAHEXAENOIC ACID;
   MICROGLIAL CELLS
AB Background: Most of the recent reports suggest that inflammatory mediators play a central role in the etiopathogenesis of Alzheimer's disease (AD) and that the conditions leading to a chronic low-grade inflammation, such as stress, depression, obesity and metabolic syndrome, increase the odds of developing Mild Cognitive Impairment (MCI) and AD. Microglia cells are the main actors in the AD process: stimuli from the microenvironment may induce microglia cells to switch to a classically activated inflammatory phenotype M1, or, on the contrary to an alternatively activated M2 phenotype characterized by the secretion of different types of cytokines. Many attempts are currently being made in order to delay the progression of AD by reducing inflammatory mechanisms underlying the disease. Several studies support a relationship among neuroinflammation and nutrients, foods or dietary patterns, taking into account the synergistic or antagonistic biochemical interactions among nutrients as well as the different food sources of the same nutrient. Natural antioxidant and anti-inflammatory compounds found in plant foods, such as fruits, particularly berries (such as strawberry, blueberry, blackcurrant, blackberry, blueberry and mulberry) have been shown to exert neuroprotective activity. It is still unclear whether the dietary bioactive compounds enter the Blood Brain Barrier (BBB) playing a direct anti-inflammatory or pro-inflammatory effect on microglia and/or other Central Nervous System (CNS) cells. Another hypothesis is that they may trigger a peripheral reaction that induce indirectly a CNS' response. The subsequent synthesis of cytokines may drive microglia polarization by different ways. So, via an indirect route microglia detects and responds to immune-to-brain signaling.
   Conclusion: This review summarizes current evidence about the potential mechanisms of the interaction among diet, neuroinflammation and AD.
C1 [Businaro, R.; Corsi, M.] Sapienza Univ Rome, Dept Medicosurg Sci & Biotechnol, Rome, Italy.
   [Asprino, R.; Pinto, A.] Sapienza Univ Rome, Food Sci & Endocrinol Sect, Med Physiopathol, Dept Expt Med, Rome, Italy.
   [Di Lorenzo, C.] Don Carlo Gnocchi Onlus Fdn, Milan, Italy.
   [Laskin, D.] Rutgers State Univ, Ernest Mario Sch Pharm, Dept Pharmacol, Piscataway, NJ USA.
   [Laskin, D.] Rutgers State Univ, Ernest Mario Sch Pharm, Dept Toxicol, Piscataway, NJ USA.
   [Corbo, R. M.] Sapienza Univ Rome, Dept Biol & Biotechnol Charles Darwin, Rome, Italy.
   [Ricci, S.] Sapienza Univ Rome, Dept Anat Sci Histol Legal Med & Locomotor Appara, Rome, Italy.
C3 Sapienza University Rome; Sapienza University Rome; IRCCS Fondazione Don
   Carlo Gnocchi Onlus; Rutgers University System; Rutgers University New
   Brunswick; Rutgers University System; Rutgers University New Brunswick;
   Sapienza University Rome; Sapienza University Rome
RP Businaro, R (corresponding author), Sapienza Univ Rome, Dept Medicosurg Sci & Biotechnol, Rome, Italy.
EM rita.businaro@uniroma1.it
RI Businaro, Rita/AAG-1866-2021
OI Corsi, Mariangela/0000-0001-5767-395X; RICCI,
   Serafino/0000-0002-7433-5749; Pinto, Alessandro/0000-0002-4864-2294;
   Laskin, Debra/0000-0003-1832-7311; reverberi,
   massimo/0000-0003-3671-6783
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NR 123
TC 55
Z9 57
U1 2
U2 55
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1567-2050
EI 1875-5828
J9 CURR ALZHEIMER RES
JI Curr. Alzheimer Res.
PY 2018
VL 15
IS 4
BP 363
EP 380
DI 10.2174/1567205014666170829100100
PG 18
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA FY2AR
UT WOS:000426616800007
PM 28847284
DA 2025-06-11
ER

PT J
AU Tripathi, AK
   Ray, AK
   Mishra, SK
AF Tripathi, Amit Kumar
   Ray, Anup Kumar
   Mishra, Sunil Kumar
TI Molecular and pharmacological aspects of piperine as a potential
   molecule for disease prevention and management: evidence from clinical
   trials
SO BENI-SUEF UNIVERSITY JOURNAL OF BASIC AND APPLIED SCIENCES
LA English
DT Review
DE Anticancer; Piperine; Pharmacokinetics; Extractions; Clinical trials;
   COVID-19; Gut microbiota
ID WNT/BETA-CATENIN PATHWAY; SYSTEMIC OXIDATIVE STRESS; CARBON-DIOXIDE
   EXTRACTION; NORA EFFLUX PUMP; NF-KAPPA-B; BLACK PEPPER; ASSISTED
   EXTRACTION; INDUCED NEURODEGENERATION; INTESTINAL-ABSORPTION; METABOLIC
   SYNDROME
AB Background: Piperine is a type of amide alkaloid that exhibits pleiotropic properties like antioxidant, anticancer, anti-inflammatory, antihypertensive, hepatoprotective, neuroprotective and enhancing bioavailability and fertility-related activities. Piperine has the ability to alter gastrointestinal disorders, drug-metabolizing enzymes, and bioavailability of several drugs. The present review explores the available clinical and preclinical data, nanoformulations, extraction process, structure-activity relationships, molecular docking, bioavailability enhancement of phytochemicals and drugs, and brain penetration properties of piperine in the prevention, management, and treatment of various diseases and disorders.
   Main body: Piperine provides therapeutic benefits in patients suffering from diabetes, obesity, arthritis, oral cancer, breast cancer, multiple myeloma, metabolic syndrome, hypertension, Parkinson's disease, Alzheimer's disease, cerebral stroke, cardiovascular diseases, kidney diseases, inflammatory diseases, and rhinopharyngitis. The molecular basis for the pleiotropic activities of piperine is based on its ability to regulate multiple signaling molecules such as cell cycle proteins, anti-apoptotic proteins, P-glycoprotein, cytochrome P450 3A4, multidrug resistance protein 1, breast cancer resistance protein, transient receptor potential vanilloid 1 proinflammatory cytokine, nuclear factor-kB, c-Fos, cAMP response element-binding protein, activation transcription factor-2, peroxisome proliferator-activated receptorgamma, Human G-quadruplex DNA, Cyclooxygenase-2, Nitric oxide synthases-2, MicroRNA, and coronaviruses. Piperine also regulates multiple signaling pathways such as Akt/mTOR/MMP-9, 5'-AMP-activated protein kinase-activated NLR family pyrin domain containing-3 inflammasome, voltage-gated K+ current, PKC alpha/ERK1/2, NF-kB/AP-1/MMP-9, Wnt/beta-catenin, JNK/P38 MAPK, and gut microbiota.
   Short conclusion: Based on the current evidence, piperine can be the potential molecule for treatment of disease, and its significance of this molecule in the clinic is discussed.
C1 [Tripathi, Amit Kumar] Banaras Hindu Univ, Inst Med Sci, Mol Biol Unit, Varanasi 221005, Uttar Pradesh, India.
   [Tripathi, Amit Kumar] Galgotias Univ, Sch Basic & Appl Sci, Clin Res Div, Gautam Buddha Nagar, UP, India.
   [Ray, Anup Kumar; Mishra, Sunil Kumar] Banaras Hindu Univ, Dept Pharmaceut Engn & Technol, Indian Inst Technol, Varanasi 221005, Uttar Pradesh, India.
   [Ray, Anup Kumar] ITS Coll Pharm, Dept Pharmacognosy, Ghaziabad 201206, UP, India.
C3 Banaras Hindu University (BHU); Galgotias University; Indian Institute
   of Technology System (IIT System); Indian Institute of Technology BHU
   Varanasi (IIT BHU Varanasi); Banaras Hindu University (BHU)
RP Mishra, SK (corresponding author), Banaras Hindu Univ, Dept Pharmaceut Engn & Technol, Indian Inst Technol, Varanasi 221005, Uttar Pradesh, India.
EM skmishra.phe@iitbhu.ac.in
RI Mishra, Sunil/AAX-9086-2020; Ray, Anup/KIG-2146-2024; TRIPATHI,
   AMIT/ABD-1565-2020
OI TRIPATHI, AMIT KUMAR/0000-0002-8327-9099; Ray, Anup/0000-0002-6823-6613
FU Department of Science and Technology-Science and Engineering Research
   Board [PDF/2016/002996/LS]; Indian Institute of Technology (Banaras
   Hindu University)
FX Department of Science and Technology-Science and Engineering Research
   Board (PDF/2016/002996/LS) and Indian Institute of Technology (Banaras
   Hindu University).
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NR 191
TC 92
Z9 93
U1 6
U2 33
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
EI 2314-8543
J9 BENI-SUEF U J BASIC
JI Beni-Suef Univ. J. Basic Appl. Sci.
PD JAN 28
PY 2022
VL 11
IS 1
AR 16
DI 10.1186/s43088-022-00196-1
PG 24
WC Multidisciplinary Sciences
WE Emerging Sources Citation Index (ESCI)
SC Science & Technology - Other Topics
GA YQ3EC
UT WOS:000749194600001
PM 35127957
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Korivi, M
   Huang, YW
   Liu, BR
AF Korivi, Mallikarjuna
   Huang, Yue-Wern
   Liu, Betty R.
TI Cell-Penetrating Peptides as a Potential Drug Delivery System for
   Effective Treatment of Diabetes
SO CURRENT PHARMACEUTICAL DESIGN
LA English
DT Review
DE Cell-penetrating peptides (CPPs); diabetes; drug delivery system (DDS);
   hyperglycemia; metabolic syndrome (MetS); type 2 diabetes (T2D)
ID METABOLIC SYNDROME; INTESTINAL-ABSORPTION; ORAL DELIVERY; QUANTUM DOTS;
   NONCOVALENT STRATEGY; BETA-CYCLODEXTRIN; TAT PROTEIN; INSULIN;
   PREVALENCE; IMPROVE
AB Background/Purpose: Type 2 diabetes (T2D) is characterized by hyperglycemia resulting from the body's inability to produce and/or use insulin. Patients with T2D often have hyperinsulinemia, dyslipidemia, inflammation, and oxidative stress, which then lead to hypertension, chronic kidney disease, cardiovascular disease, and increased risk of morbidity and mortality (9th leading cause globally). Insulin and related pharmacological therapies are widely used to manage T2D, despite their limitations. Efficient drug delivery systems (DDS) that control drug kinetics may decrease side effects, allow for efficient targeting, and increase the bioavailability of drugs to achieve maximum therapeutic benefits. Thus, the development of effective DDS is crucial to beat diabetes.
   Methods: Here, we introduced a highly bioavailable vector, cell-penetrating peptides (CPPs), as a powerful DDS to overcome limitations of free drug administration.
   Results: CPPs are short peptides that serve as a potent tool for delivering therapeutic agents across cell membranes. Various cargoes, including proteins, DNA, RNA, liposomes, therapeutic molecules, and nanomaterials, generally retain their bioactivity upon entering cells. The mechanisms of CPPs/cargoes intracellular entry are classified into two parts: endocytic pathways and direct membrane translocation. In this article, we focus on the applications of CPPs/therapeutic agents in the treatment of diabetes. Hypoglycemic drugs with CPPs intervention can enhance therapeutic effectiveness, and CPP-mediated drug delivery can facilitate the actions of insulin. Numerous studies indicate that CPPs can effectively deliver insulin, produce synergistic effects with immunosuppressants for successful pancreatic islet xenotransplantation, prolong pharmacokinetics, and retard diabetic nephropathy.
   Conclusion: We suggest that CPPs can be a new generation of drug delivery systems for effective treatment and management of diabetes and diabetes-associated complications.
C1 [Korivi, Mallikarjuna] Zhejiang Normal Univ, Coll Phys Educ & Hlth Sci, Exercise & Metab Res Ctr, Jinhua, Zhejiang, Peoples R China.
   [Huang, Yue-Wern] Missouri Univ Sci & Technol, Dept Biol Sci, Rolla, MO 65409 USA.
   [Liu, Betty R.] Tzu Chi Univ, Coll Med, Dept Lab Med & Biotechnol, 701,Sec 3,Zhongyang Rd, Hualien 97004, Taiwan.
C3 Zhejiang Normal University; University of Missouri System; Missouri
   University of Science & Technology; Tzu Chi University
RP Liu, BR (corresponding author), Tzu Chi Univ, Coll Med, Dept Lab Med & Biotechnol, 701,Sec 3,Zhongyang Rd, Hualien 97004, Taiwan.
EM brliu7447@gms.tcu.edu.tw
RI Liu, Betty Revon/GLU-3300-2022; Korivi, Mallikarjuna/C-7952-2012
OI Korivi, Mallikarjuna/0000-0002-4038-1368; Liu, Betty
   Revon/0000-0002-5152-8687; Huang, Yue-Wern/0000-0003-1957-6459
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NR 103
TC 9
Z9 9
U1 3
U2 47
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1381-6128
EI 1873-4286
J9 CURR PHARM DESIGN
JI Curr. Pharm. Design
PY 2021
VL 27
IS 6
BP 816
EP 825
DI 10.2174/1381612826666201019102640
PG 10
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA RB9UV
UT WOS:000632451200006
PM 33076803
DA 2025-06-11
ER

PT J
AU Huerta-Delgado, AS
   Roffe-Vazquez, DN
   Gonzalez-Gil, AM
   Villarreal-Calderón, JR
   Tamez-Rivera, O
   Rodriguez-Gutierrez, NA
   Castillo, EC
   Silva-Platas, C
   Garcia-Rivas, G
   Elizondo-Montemayor, L
AF Huerta-Delgado, Anna S.
   Roffe-Vazquez, Daniel N.
   Gonzalez-Gil, Adrian M.
   Villarreal-Calderon, Jose R.
   Tamez-Rivera, Oscar
   Rodriguez-Gutierrez, Nora A.
   Castillo, Elena C.
   Silva-Platas, Christian
   Garcia-Rivas, Gerardo
   Elizondo-Montemayor, Leticia
TI Serum Irisin Levels, Endothelial Dysfunction, and Inflammation in
   Pediatric Patients with Type 2 Diabetes Mellitus and Metabolic Syndrome
SO JOURNAL OF DIABETES RESEARCH
LA English
DT Article
ID CELL-ADHESION MOLECULE-1; SKELETAL-MUSCLE; CIRCULATING IRISIN;
   INSULIN-RESISTANCE; ADIPOSE-TISSUE; SYNDROME PHENOTYPE;
   PHYSICAL-ACTIVITY; OBESE CHILDREN; MYOKINE IRISIN; CROSS-TALK
AB The prevalence of type 2 diabetes mellitus (T2DM) and metabolic syndrome (MetS) has increased in the pediatric population. Irisin, an adipomyokine, is involved in white adipose tissue browning, energy expenditure, insulin sensitivity, and anti-inflammatory pathways. Data on the associations among circulating irisin levels, soluble cell adhesion molecules (sCAMs), and inflammatory cytokines is scarce in children and adolescents with MetS and T2DM. Subjects aged 6-16 years were grouped into T2DM, MetS, and healthy controls. Serum irisin levels were significantly lower in the MetS (6.6 [2.8-18.0] ng/mL) and T2DM (6.8 [2.2-23.2] ng/mL) groups compared with controls (30.3 [24.6-57.1] ng/mL). Negative correlations between irisin and the BMI percentile (R=-0.358), WC percentile (R=-0.308), and triglycerides (R=-0.284) were identified, while positive associations with TC (R=0.287), HDL-c (R=0.488), and LDL-c (R=0.414) were observed. Significant negative correlations were found between irisin and sNCAM (R=-0.382), sICAM-2 (R=-0.300), sVCAM-1 (R=-0.292), MCP-1 (R=-0.308), and IFN-alpha 2 (R=-0.406). Of note, lower concentrations of most sCAMs (sICAM-1, sPSGL-1, sP-selectin, sEpCAM, sICAM-2, sALCAM, sPECAM-1, sCD44, sVCAM-1, sICAM-3, sL-selectin, and sNCAM) were shown in T2DM subjects compared with MetS patients. Lower irisin levels induce a lack of inhibition of oxidative stress and inflammation. In T2DM, higher ROS, AGEs, glucotoxicity, and inflammation trigger endothelial cell apoptosis, which downregulates the sCAM expression as a compensatory mechanism to prevent further vascular damage. In opposition, in subjects with MetS that have not yet developed T2DM and its accompanying stressors, the upregulation of the sCAM expression is ensued.
C1 [Huerta-Delgado, Anna S.; Roffe-Vazquez, Daniel N.; Gonzalez-Gil, Adrian M.; Villarreal-Calderon, Jose R.; Elizondo-Montemayor, Leticia] Tecnol Monterrey, Escuela Med, Ctr Res Obes & Clin Nutr, Monterrey 64710, Mexico.
   [Tamez-Rivera, Oscar] Hosp Zambrano, Tecnol Monterrey, Dept Pediat, San Pedro Garza Garcia 66278, Mexico.
   [Rodriguez-Gutierrez, Nora A.] Hosp Reg Alta Especialidad Materno Infantil, Dept Pediat, Guadalupe 67140, Mexico.
   [Castillo, Elena C.; Silva-Platas, Christian; Garcia-Rivas, Gerardo] Hosp Zambrano Hell, Tecnol Monterrey, Ctr Biomed Res, San Pedro Garza Garcia 66278, Mexico.
   [Garcia-Rivas, Gerardo; Elizondo-Montemayor, Leticia] Hosp Zambrano Hell, Tecnol Monterrey, Cardiovasc Med & Metabol Res Grp, San Pedro Garza Garcia 66278, Mexico.
C3 Tecnologico de Monterrey; Tecnologico de Monterrey; Tecnologico de
   Monterrey; Tecnologico de Monterrey
RP Elizondo-Montemayor, L (corresponding author), Tecnol Monterrey, Escuela Med, Ctr Res Obes & Clin Nutr, Monterrey 64710, Mexico.; Elizondo-Montemayor, L (corresponding author), Hosp Zambrano Hell, Tecnol Monterrey, Cardiovasc Med & Metabol Res Grp, San Pedro Garza Garcia 66278, Mexico.
EM anna.sofy@hotmail.com; daniel.roffe@hotmail.com;
   amgonzalezgil@hotmail.com; joser.villarreal@udem.edu;
   otr_39@hotmail.com; norardzg@gmail.com; ecgonzalez@itesm.mx;
   plattas@tec.mx; gdejesus@itesm.mx; lelizond@itesm.mx
RI Tamez-Rivera, Oscar/HMV-7807-2023; García-Rivas, Gerardo/F-5994-2012;
   Silva-Platas, Christian/E-6777-2010; Garcia-Rivas, Gerardo/A-9691-2011
OI Garcia-Rivas, Gerardo/0000-0003-4731-3293; Huerta-Delgado, Anna
   S./0000-0002-5098-8163; Villarreal Calderon, Jose
   Romeo/0000-0001-7484-1476; Roffe-Vazquez, Daniel N./0000-0001-7613-8952;
   Gonzalez, Marcelo/0000-0002-3379-1916; Tamez, Oscar/0000-0002-1199-7884
FU Center for Research in Obesity and Clinical Nutrition, Tecnologico de
   Monterrey; CONACYT [256577, s1-s-48883]
FX This research was funded by the Center for Research in Obesity and
   Clinical Nutrition, Tecnologico de Monterrey (L.E.M.), and by the
   CONACYT grant numbers (256577 and s1-s-48883) (G.G.R.). The authors
   would like to acknowledge Mariana Peschard-Franco and Carla
   Toledo-Salinas for their invaluable fieldwork (Center for Research in
   Obesity and Clinical Nutrition, Tecnologico de Monterrey-Escuela de
   Medicina, Monterrey 64710, Mexico).
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NR 101
TC 30
Z9 32
U1 0
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2314-6745
EI 2314-6753
J9 J DIABETES RES
JI J. Diabetes Res.
PD SEP 7
PY 2020
VL 2020
AR 1949415
DI 10.1155/2020/1949415
PG 16
WC Endocrinology & Metabolism; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Research & Experimental Medicine
GA NW0KI
UT WOS:000574698000002
PM 32964051
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Besiroglu, H
   Ozbek, E
AF Besiroglu, Huseyin
   Ozbek, Emin
TI Association between blood lipid profile and urolithiasis: A systematic
   review and meta-analysis of observational studies
SO INTERNATIONAL JOURNAL OF UROLOGY
LA English
DT Review
DE dyslipidemia; high-density lipoprotein; metabolic syndrome;
   triglyceride; urolithiasis
ID METABOLIC SYNDROME; KIDNEY-STONES; OXIDATIVE STRESS; DIABETES-MELLITUS;
   PHYSICAL-ACTIVITY; RISK-FACTORS; URINE PH; NEPHROLITHIASIS;
   HYPERTENSION; DISEASE
AB The objective of this study was to pool individual studies regarding the association of blood lipid profiles with urolithiasis to carry out a systematic review and meta-analysis. We searched MEDLINE, PubMed, Embase and Cochrane Library to identify the relevant studies up to November 2017. Studies that met all inclusion criteria were chosen, and a pooled analysis of the odds ratio between urolithiasis and dyslipidemia traits was calculated. A total of 11 observational studies (seven cross-sectional, three cohort, one case-control) with a total of 282 479 participants were examined. The overall pooled analysis of eight studies showed that high triglyceride was associated with increased estimated risk of urolithiasis (odds ratio 1.287, 95% CI 1.073-1.544; P = 0.007). Estimates of the total effect size were consistent in the sensitivity analysis. No evidence of publication bias was detected. The overall pooled analysis of nine studies showed low high-density lipoprotein was weakly associated with increased estimated risk of urolithiasis (odds ratio 1.171, 95% CI 1.010-1.358; P = 0.032). The sensitivity analysis showed conflicting results. No evidence of publication bias was detected. Three studies on the association between any dyslipidemia traits and urolithiasis showed a significant association (odds ratio 1.309, 95% CI 1.202-1.425; P < 0.001). The present meta-analysis showed that patients with higher triglyceride and lower high-density lipoprotein had an increased estimated risk of urolithiasis. A triglyceride-urolithiasis association was found to be more coherent and consistent compared with the high-density lipoprotein-urolithiasis association. Although somewhat contradictory results have been found, the meta-analysis is encouraging for evaluating urolithiasis as a systemic disorder. Further well-designed prospective randomized controlled or cohort studies are necessary to better elucidate the causal association of dyslipidemia and urolithiasis.
C1 [Besiroglu, Huseyin] Catalca Ilyas Cokay State Hosp, Dept Urol, Istanbul, Turkey.
   [Ozbek, Emin] Istanbul Univ, Cerrahpasa Med Fac, Dept Urol, Istanbul, Turkey.
C3 Catalca Ilyas Cokay State Hospital; Istanbul University; Istanbul
   University - Cerrahpasa
RP Besiroglu, H (corresponding author), Catalca Ilyas Cokay State Hosp, Dept Urol, Istanbul, Turkey.
EM drhuseyin1985@hotmail.com
RI Besiroglu, Huseyin/AAM-5318-2020
OI Besiroglu, Huseyin/0000-0002-7459-584X
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NR 48
TC 9
Z9 9
U1 1
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0919-8172
EI 1442-2042
J9 INT J UROL
JI Int. J. Urol.
PD JAN
PY 2019
VL 26
IS 1
BP 7
EP 17
DI 10.1111/iju.13781
PG 11
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA HH1TT
UT WOS:000455503300002
PM 30151863
OA Bronze
DA 2025-06-11
ER

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AU Rahmani, S
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   Askari, G
   Keshvari, M
   Hatamipour, M
   Feizi, A
   Sahebkar, A
AF Rahmani, Sepideh
   Asgary, Sedigheh
   Askari, Gholamreza
   Keshvari, Mahtab
   Hatamipour, Mahdi
   Feizi, Awat
   Sahebkar, Amirhossein
TI Treatment of Non-alcoholic Fatty Liver Disease with Curcumin: A
   Randomized Placebo-controlled Trial
SO PHYTOTHERAPY RESEARCH
LA English
DT Article
DE fatty liver; insulin resistance; metabolic syndrome; curcuminoids;
   Curcuma longa
ID C-REACTIVE PROTEIN; QUALITY-OF-LIFE; CHRONIC PULMONARY COMPLICATIONS;
   SYSTEMIC OXIDATIVE STRESS; SULFUR MUSTARD; DOUBLE-BLIND; PIPERINE
   COMBINATION; METABOLIC SYNDROME; 3T3-L1 ADIPOCYTES; CLINICAL-PRACTICE
AB Non-alcoholic fatty liver disease (NAFLD) is a global health problem. Although many aspects of NAFLD pathogenesis have been understood, there is a paucity of effective treatments to be used as the second line when lifestyle modification is insufficient. Curcumin, a natural polyphenol from turmeric, has been shown to be effective against development of hepatic steatosis and its progression to steatohepatitis, yet these beneficial effects have not been explored in clinical practice. The aim of this study is to investigate the effects of curcumin on hepatic fat content as well as biochemical and anthropometric features of patients with NAFLD. In this randomized double-blind placebo-controlled trial, patients with ultrasonographic evidence of NAFLD were randomly assigned to receive an amorphous dispersion curcumin formulation (500 mg/day equivalent to 70-mg curcumin) or matched placebo for a period of 8 weeks. Liver fat content (assessed through ultrasonography), glycemic and lipid profile, transaminase levels, and anthropometric indices were evaluated at baseline and at the end of follow-up period. The clinical trial protocol was registered under the Iranian Registry of Clinical Trials ID: IRCT2014110511763N18. Compared with placebo, curcumin was associated with a significant reduction in liver fat content (78.9% improvement in the curcumin vs 27.5% improvement in the placebo group). There were also significant reductions in body mass index and serum levels of total cholesterol, low-density lipoprotein cholesterol, triglycerides, aspartate aminotransferase, alanine aminotransferase, glucose, and glycated hemoglobin compared with the placebo group. Curcumin was safe and well tolerated during the course of trial. Findings of the present proof-of-concept trial suggested improvement of different features of NAFLD after a short-term supplementation with curcumin. Copyright (C) 2016 John Wiley & Sons, Ltd.
C1 [Rahmani, Sepideh; Askari, Gholamreza] Isfahan Univ Med Sci, Food Secur Res Ctr, Esfahan, Iran.
   [Asgary, Sedigheh; Keshvari, Mahtab] Isfahan Univ Med Sci, Cardiovasc Res Inst, Isfahan Cardiovasc Res Ctr, Esfahan, Iran.
   [Hatamipour, Mahdi] Mashhad Univ Med Sci, Sch Pharm, Neurogen Inflammat Res Ctr, Nanotechnol Res Ctr, Mashhad, Iran.
   [Feizi, Awat] Isfahan Univ Med Sci, Sch Hlth, Dept Epidemiol & Biostat, Esfahan, Iran.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Biotechnol Res Ctr, Mashhad, Iran.
   [Sahebkar, Amirhossein] Univ Western Australia, Sch Med & Pharmacol, Royal Perth Hosp, Metab Res Ctr, Perth, WA, Australia.
C3 Isfahan University of Medical Sciences; Isfahan University of Medical
   Sciences; Mashhad University of Medical Sciences; Isfahan University of
   Medical Sciences; Mashhad University of Medical Sciences; University of
   Western Australia; East Metropolitan Health Service; Royal Perth
   Hospital
RP Asgary, S (corresponding author), Isfahan Univ Med Sci, Cardiovasc Res Inst, Isfahan Cardiovasc Res Ctr, Esfahan, Iran.
EM sedighehasgary@gmail.com
RI Sahebkar, Amirhossein/B-5124-2018; keshvari, mahtab/ABD-4038-2020;
   askari, gholamreza/M-9362-2016; Feizi, Awat/W-3409-2017
OI Feizi, Awat/0000-0002-1930-0340; keshvari, mahtab/0000-0003-0919-4406;
   askari, gholamreza/0000-0003-1194-9687
FU Isfahan University of Medical Sciences (Isfahan, Iran); Iran National
   Science Foundation (INSF)
FX This study was financially supported by the Isfahan University of
   Medical Sciences (Isfahan, Iran). The financial support provided by the
   Iran National Science Foundation (INSF) is also gratefully acknowledged.
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NR 54
TC 340
Z9 346
U1 7
U2 110
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0951-418X
EI 1099-1573
J9 PHYTOTHER RES
JI Phytother. Res.
PD SEP
PY 2016
VL 30
IS 9
BP 1540
EP 1548
DI 10.1002/ptr.5659
PG 9
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA DZ2VO
UT WOS:000385699900016
PM 27270872
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Uribarri, J
   Cai, WJ
   Woodward, M
   Tripp, E
   Goldberg, L
   Pyzik, R
   Yee, K
   Tansman, L
   Chen, X
   Mani, V
   Fayad, ZA
   Vlassara, H
AF Uribarri, Jaime
   Cai, Weijing
   Woodward, Mark
   Tripp, Elizabeth
   Goldberg, Laurie
   Pyzik, Renata
   Yee, Kalle
   Tansman, Laurie
   Chen, Xue
   Mani, Venkatesh
   Fayad, Zahi A.
   Vlassara, Helen
TI Elevated Serum Advanced Glycation Endproducts in Obese Indicate Risk for
   the Metabolic Syndrome: A Link Between Healthy and Unhealthy Obesity?
SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Article
ID INSULIN-RESISTANCE; END-PRODUCTS; OXIDATIVE STRESS; INFLAMMATORY
   RESPONSE; DIABETES-MELLITUS; AGE RECEPTOR-1; ADIPOSE-TISSUE; SIRTUIN 1;
   DISEASE; FOODS
AB Context: Although obesity can predispose to the metabolic syndrome (MS), diabetes, and cardiovascular disease, not all obese subjects develop MS, hence the need for new indicators of risk for this syndrome. Advanced glycation end products (AGEs) correlate with factors involved in the MS, including inflammation and insulin resistance (IR). Because AGEs can be derived from food and are modifiable, it is important to determine whether they are a risk factor for MS.
   Objective: The objective of this study was to assess the association of endogenous and exogenous AGEs with MS criteria.
   Design: The following data were collected in a cross-sectional study of subjects with and without the MS: serum AGEs (sAGEs) and mononuclear cell AGEs, metabolites, pro-and antiinflammatory markers, body fat mass measures, including abdominal magnetic resonance imaging, and caloric and dietary AGE (dAGE) consumption.
   Setting: The study was conducted in the general community.
   Participants: Participants included 130 MS and 139 non-MS subjects of both sexes, older than 50 years.
   Results: sAGEs (N-epsilon-carboxymethyllysine, methylglyoxal) were markedly elevated in obese persons with more than one other MS criteria but not in obese without MS criteria. sAGEs directly correlated with markers of IR (HOMA) and inflammation (leptin, TNF alpha, RAGE) and inversely with innate defenses (SIRT1, AGE receptor 1 [AGER1], glyoxalase-I, adiponectin). sAGEs correlated with dAGEs but not with calories, nutrient consumption, or fat mass measures. Consumption of dAGE, but not of calories, was markedly higher in MS than in non-MS.
   Conclusion: High sAGEs, a modifiable risk factor for IR, mayindicate risk for the MS, type 2 diabetes, and cardiovascular disease. High dietary AGE consumption and serum AGE levels may link healthy obesity to at-risk obesity.
C1 [Cai, Weijing; Tripp, Elizabeth; Goldberg, Laurie; Pyzik, Renata; Yee, Kalle; Tansman, Laurie; Chen, Xue; Vlassara, Helen] Icahn Sch Med Mt Sinai, Dept Geriatr, Div Expt Diabet, New York, NY 10029 USA.
   [Uribarri, Jaime; Vlassara, Helen] Icahn Sch Med Mt Sinai, Dept Med, Div Nephrol, New York, NY 10029 USA.
   [Mani, Venkatesh; Fayad, Zahi A.] Icahn Sch Med Mt Sinai, Translat & Mol Imaging Inst, New York, NY 10029 USA.
   [Woodward, Mark] Univ Oxford, George Inst Global Hlth, Oxford OX1 3QX, England.
   Univ Sydney, Sydney, NSW 2006, Australia.
C3 Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at
   Mount Sinai; Icahn School of Medicine at Mount Sinai; University of
   Oxford; University of Sydney
RP Vlassara, H (corresponding author), Icahn Sch Med Mt Sinai, Dept Geriatr, One Gustave Levy Pl, New York, NY 10029 USA.
EM helen.vlassara@mssm.edu
RI Uribarri, Jaime/ADX-7655-2022; Woodward, Mark/L-6817-2017; Fayad,
   Zahi/Z-3272-2019; Mani, Venkatesh/B-8939-2011
OI Mani, Venkatesh/0000-0002-0432-2918; Woodward, Mark/0000-0001-9800-5296;
   uribarri, jaime/0000-0001-9826-1134
FU National Institutes of Health [DK091231]; National Institute of Research
   Resources Grant [MO1-RR-00071]
FX This work was supported by National Institutes of Health Grant DK091231
   (to H.V.) and National Institute of Research Resources Grant
   MO1-RR-00071 (awarded to the General Clinical Research Center at Mount
   Sinai School of Medicine) for clinical and statistical support.
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NR 39
TC 114
Z9 119
U1 0
U2 23
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0021-972X
EI 1945-7197
J9 J CLIN ENDOCR METAB
JI J. Clin. Endocrinol. Metab.
PD MAY
PY 2015
VL 100
IS 5
BP 1957
EP 1966
DI 10.1210/jc.2014-3925
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA CM4QG
UT WOS:000357669000050
PM 25695886
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Tao, ZX
   Zuo, PF
   Ma, GS
AF Tao, Zaixiao
   Zuo, Pengfei
   Ma, Genshan
TI Association of weight-adjusted waist index with cardiovascular disease
   and mortality among metabolic syndrome population
SO SCIENTIFIC REPORTS
LA English
DT Article
DE Weight-adjusted waist circumference index; WWI; Metabolic syndrome;
   MetS; NHANES
ID ENDOTHELIAL DYSFUNCTION; OXIDATIVE STRESS; OBESITY; TRENDS; PREVALENCE;
   ADULTS; RISK
AB Metabolic syndrome (MetS) is prevalent and significantly impacts global public health, with obesity being a major risk factor for cardiovascular diseases (CVD) and mortality. Traditional metrics like body mass index (BMI) have limitations in assessing obesity-related risks. The weight-adjusted waist circumference index (WWI) has emerged as a novel obesity metric, this study aimed to evaluate the association of WWI with CVD and mortality in MetS patients. This study used data from 12,641 participants with MetS, derived from the National Health and Nutrition Examination Survey (NHANES) conducted from 1999 to 2020. The WWI was calculated, and its association with CVD and mortality was assessed using multivariate logistic and Cox regression models. The study controlled for potential confounders and performed subgroup and sensitivity analyses to validate the robustness of the findings. The predictive performance of WWI was evaluated using the area under the receiver operating characteristic curve (ROC). Kaplan-Meier (KM) curves further were used to evaluate the associations between WWI and mortality of the MetS population. As WWI values escalated, there was a proportional rise in the risk of CVD and mortality in MetS. The fully adjusted continuous model revealed a 32.0% elevated likelihood of CVD development, a 69.5% increased probability of heart failure (HF), a 51.1% heightened risk for CVD mortality, and a 22.8% augmented risk for all-cause mortality with each one-unit increment in WWI. Comparing the highest to the lowest quartile of WWI, the top quartile exhibited a significantly increased risk of CVD (odds ratio [OR] = 1.883; 95% confidence interval [CI]: 1.276-2.633, p-value = 0.001), HF (OR = 2.909; 95% CI: 1.490-5.677, p-value = 0.002), CVD mortality (hazard ratio [HR] = 2.088; 95% CI: 1.279-3.409, p-value = 0.003), and all-cause mortality (HR = 1.394; 95% CI: 1.070-1.816, p-value = 0.014) among individuals with MetS. Sensitivity and subgroup analyses substantiated the consistency and stability of these associations across various demographic groups. The ROC analysis demonstrated that WWI outperforms BMI in predicting adverse outcomes in MetS. The KM curves validated that higher WWI values was correlated with diminished survival rates in MetS population. The WWI served as a significant indicator for assessing the risk of CVD and mortality in the MetS population. This study recommended the regular assessment of WWI in MetS individuals for evaluating their risk of CVD and mortality, potentially enhancing preventive and treatment strategies for this patient population.
C1 [Tao, Zaixiao; Zuo, Pengfei; Ma, Genshan] Southeast Univ, Zhongda Hosp, Sch Med, Dept Cardiol, Nanjing, Peoples R China.
   [Tao, Zaixiao; Zuo, Pengfei; Ma, Genshan] Southeast Univ, Sch Med, Nanjing, Peoples R China.
C3 Southeast University - China; Southeast University - China
RP Zuo, PF; Ma, GS (corresponding author), Southeast Univ, Zhongda Hosp, Sch Med, Dept Cardiol, Nanjing, Peoples R China.; Zuo, PF; Ma, GS (corresponding author), Southeast Univ, Sch Med, Nanjing, Peoples R China.
EM zuopengfei1207@sina.com; magenshan@hotmail.com
FU National Natural Science Foundation of China
FX The authors thank the staff and the participants of the NHANES study for
   their valuable contributions.
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NR 46
TC 8
Z9 8
U1 5
U2 10
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD AUG 12
PY 2024
VL 14
IS 1
AR 18684
DI 10.1038/s41598-024-69486-1
PG 15
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA C6A6B
UT WOS:001290178500084
PM 39134613
OA gold
DA 2025-06-11
ER

PT J
AU Attia, H
   Albekairi, N
   Albdeirat, L
   Soliman, A
   Rajab, R
   Alotaibi, H
   Ali, R
   Badr, A
AF Attia, Hala
   Albekairi, Norah
   Albdeirat, Layal
   Soliman, Arwa
   Rajab, Reem
   Alotaibi, Hend
   Ali, Rehab
   Badr, Amira
TI Chrysin Attenuates Fructose-Induced Nonalcoholic Fatty Liver in Rats via
   Antioxidant and Anti-Inflammatory Effects: The Role of
   Angiotensin-Converting Enzyme 2/Angiotensin (1-7)/Mas Receptor Axis
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Article
ID INSULIN-RESISTANCE; METABOLIC SYNDROME; DISEASE; SYSTEM; DIET;
   PATHOGENESIS; MODULATION; STEATOSIS
AB Aim. Nonalcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic syndrome, and if untreated, it may propagate into end-stage liver disease. The classical arm of the renin-angiotensin system (RAS) has a fundamental role in triggering oxidative stress and inflammation, which play potential roles in the pathogenesis of NAFLD. However, the nonclassical alternative axis of RAS, angiotensin- (Ang-) converting enzyme 2 (ACE2)/Ang (1-7)/Mas receptor, opposes the actions of the classical arm, mitigates the metabolic dysfunction, and improves hepatic lipid metabolism rendering it a promising protective target against NAFLD. The current study is aimed at investigating the impact of chrysin, a well-known antioxidant flavonoid, on this defensive RAS axis in NAFLD. Methods. Rats were randomly distributed and treated daily for eight weeks as follows: the normal control, chrysin control (50 mg/kg, p.o), NAFLD group (received 20% fructose in drinking water), and treated groups (25 and 50 mg/kg chrysin given orally and concomitantly with fructose). Diminazene aceturate (DIZE) (15 mg/kg, s.c.) was used as a reference ACE2 activator. Key Findings. High fructose induced significant weight gain, hepatocyte degeneration with fat accumulation, and inflammatory cell infiltration (as examined by H&E staining). This was accompanied by a substantial increase in liver enzymes, glucose, circulating and hepatic triglycerides, lipid peroxides, inflammatory cytokines, and Ang II (the main component of classical RAS). At the same time, protein levels of ACE2, Ang (1-7), and Mas receptors were markedly reduced. Chrysin (25 and 50 mg/kg) significantly ameliorated these abnormalities, with a prominent effect of the dose of 50 mg/kg over DIZE and the lower dose in improving ACE2, Ang (1-7), and Mas. Significance. Chrysin is a promising efficient protective remedy against NAFLD; mechanisms include the activation of ACE2/Ang (1-7)/Mas axis.
C1 [Attia, Hala; Albekairi, Norah; Alotaibi, Hend; Ali, Rehab; Badr, Amira] King Saud Univ, Coll Pharm, Dept Pharmacol & Toxicol, Riyadh 11495, Saudi Arabia.
   [Attia, Hala] Mansoura Univ, Coll Pharm, Dept Biochem, Mansoura 35516, Egypt.
   [Albdeirat, Layal; Soliman, Arwa; Rajab, Reem] King Saud Univ, Coll Pharm, Riyadh 11495, Saudi Arabia.
   [Badr, Amira] Ain Shams Univ, Coll Pharm, Dept Pharmacol & Toxicol, Cairo, Egypt.
C3 King Saud University; Egyptian Knowledge Bank (EKB); Mansoura
   University; King Saud University; Egyptian Knowledge Bank (EKB); Ain
   Shams University
RP Attia, H (corresponding author), King Saud Univ, Coll Pharm, Dept Pharmacol & Toxicol, Riyadh 11495, Saudi Arabia.; Attia, H (corresponding author), Mansoura Univ, Coll Pharm, Dept Biochem, Mansoura 35516, Egypt.
EM hsalem@ksu.edu.sa; nalbekairi@ksu.edu.sa; layal14layal7@gmail.com;
   arwasoliman60@gmail.com; reemrajab724@gmail.com; hialdajani@ksu.edu.sa;
   rehabhadad@hotmail.com; amibadr@ksu.edu.sa
RI Albekairi, Norah/JFS-9728-2023; Badr, Dr Amira/AAA-7683-2022; Attia,
   Hala/E-4526-2013
OI Albekairi, Norah/0000-0001-7296-5969; Alotaibi,
   Hind/0000-0001-8756-3700; Albdeirat, Layal/0000-0002-2719-4269; Badr, Dr
   Amira/0000-0003-3983-868X; Attia, Hala/0000-0002-0482-5363
FU Deanship of Scientific Research at King Saud University [URSP-5-20-21]
FX The authors extend their appreciation to the Deanship of Scientific
   Research at King Saud University for funding this work through the
   Undergraduate Student's Research Support Program, Project no.
   (URSP-5-20-21).
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NR 77
TC 13
Z9 13
U1 2
U2 15
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PD JUN 8
PY 2022
VL 2022
AR 9479456
DI 10.1155/2022/9479456
PG 14
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA 2G9JV
UT WOS:000813918100003
PM 35720181
OA hybrid
DA 2025-06-11
ER

PT J
AU Daneii, P
   Neshat, S
   Mirnasiry, MS
   Moghimi, Z
   Niri, FD
   Farid, A
   Shekarchizadeh, M
   Heshmat-Ghahdarijani, K
AF Daneii, Padideh
   Neshat, Sina
   Mirnasiry, Monir Sadat
   Moghimi, Zahra
   Niri, Fatemeh Dehghan
   Farid, Armita
   Shekarchizadeh, Masood
   Heshmat-Ghahdarijani, Kiyan
TI Lipids and diastolic dysfunction: Recent evidence and findings
SO NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
LA English
DT Review
DE Diastolic dysfunction; Dyslipidemia; Lipids; Review article
ID MYOCARDIAL TRIGLYCERIDE CONTENT; PRESERVED EJECTION FRACTION; EPICARDIAL
   ADIPOSE-TISSUE; LEFT-VENTRICULAR FUNCTION; FATTY LIVER-DISEASE;
   HEART-FAILURE; DIABETIC CARDIOMYOPATHY; METABOLIC SYNDROME; PATHOLOGICAL
   HYPERTROPHY; CARDIOVASCULAR-DISEASE
AB Aim: Diastolic dysfunction is the decreased flexibility of the left ventricle due to the impaired ability of the myocardium to relax and plays an important role in the pathogenesis of heart failure. Lipid metabolism is a well-known contributor to cardiac conditions, including ventricular function. In this article, we aimed to review the literature addressing the connections between lipids, their storage, and metabolism with left ventricular diastolic dysfunction.Data synthesis: We searched Google scholar, Pubmed, Embase and Researchgate for our keywords: "Diastolic function", "Fat" and "Lipid profile". Initially, 250 articles were selected by title and 84 of them were chosen as most relevant and directly reviewed.Conclusions: Alterations of lipid metabolism in cardiac muscle and cardiac lipid content can occur in many conditions, including consumption of a high-fat diet, obesity, metabolic syndrome, and non-alcoholic fatty liver disease (NAFLD). These conditions induce alterations in myocardial lipid metabolism, increase myocardial fat content and epicardial fat thickness and increase inflammation and oxidative stress which ultimately lead to cardiac lipotoxicity and diastolic dysfunction. The effects of lipids on diastolic function can differ based on gender. Lipid profile and metabolism are as important in the pathogenesis of diastolic dysfunction as they are in other cardiovascular disorders. A more careful look at cardiac lipid metabolism in molecular, histological and gross levels results in more precise understanding of its role in myocardial function and leads to development of potential treatments for diastolic dysfunction.(c) 2022 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.
C1 [Daneii, Padideh; Neshat, Sina; Mirnasiry, Monir Sadat; Moghimi, Zahra; Niri, Fatemeh Dehghan] Isfahan Univ Med Sci, Sch Med, Esfahan, Iran.
   [Farid, Armita] Iran Univ Med Sci, Sch Med, Tehran, Iran.
   [Shekarchizadeh, Masood] Isfahan Univ Med Sci, Isfahan Cardiovasc Res Ctr, Cardiovasc Res Inst, Esfahan, Iran.
   [Heshmat-Ghahdarijani, Kiyan] Isfahan Univ Med Sci, Heart Failure Res Ctr, Cardiovasc Res Inst, Esfahan, Iran.
C3 Isfahan University of Medical Sciences; Iran University of Medical
   Sciences; Isfahan University of Medical Sciences; Isfahan University of
   Medical Sciences
RP Heshmat-Ghahdarijani, K (corresponding author), Isfahan Univ Med Sci, Heart Failure Res Ctr, Cardiovasc Res Inst, Esfahan, Iran.
EM padidehdaneii@gmail.com; sinaneshat@gmail.com;
   Monir.s.mirnasiry@gmail.com; z.moghimi1@gmail.com;
   f.dehghann2014@gmail.com; armitafarid@gmail.com; kiyan_heshmat@yahoo.com
RI Farid, Armita/ADP-3853-2022; Moghimi, Zahra/HLG-3055-2023;
   shekarchizadeh, masood/AAE-6679-2022; Heshmat, Kiyan/AAP-4974-2021
OI Farid, Armita/0000-0002-7090-3323; Daneii, Padideh/0009-0004-4182-4337
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NR 109
TC 13
Z9 13
U1 2
U2 17
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0939-4753
EI 1590-3729
J9 NUTR METAB CARDIOVAS
JI Nutr. Metab. Carbiovasc. Dis.
PD JUN
PY 2022
VL 32
IS 6
BP 1343
EP 1352
DI 10.1016/j.numecd.2022.03.003
EA MAY 2022
PG 10
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism; Nutrition
   & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism;
   Nutrition & Dietetics
GA 1V3VA
UT WOS:000806020500003
PM 35428541
DA 2025-06-11
ER

PT J
AU Ailanen, L
   Vähätalo, LH
   Salomäki-Myftari, H
   Mäkelä, S
   Orpana, W
   Ruohonen, ST
   Savontaus, E
AF Ailanen, Liisa
   Vahatalo, Laura H.
   Salomaki-Myftari, Henriikka
   Makela, Satu
   Orpana, Wendy
   Ruohonen, Suvi T.
   Savontaus, Eriika
TI Peripherally Administered Y2-Receptor Antagonist BIIE0246
   Prevents Diet-Induced Obesity in Mice With Excess Neuropeptide Y, but
   Enhances Obesity in Control Mice
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Article
DE neuropeptide Y; Y-2-receptor; BIIE0246; obesity; the metabolic syndrome
ID HIGH-FAT DIET; NORADRENERGIC NEURONS; METABOLIC SYNDROME; SIGNAL
   PEPTIDE; ADIPOSE-TISSUE; WHITE SUBJECTS; DIABETIC-RATS; YY2 RECEPTOR;
   FOOD-INTAKE; NPY2R GENE
AB Neuropeptide Y (NPY) plays an important role in the regulation of energy homeostasis in the level of central and sympathetic nervous systems (SNSs). Genetic silencing of peripheral Y-2-receptors have anti-obesity effects, but it is not known whether pharmacological blocking of peripheral Y-2-receptors would similarly benefit energy homeostasis. The effects of a peripherally administered Y-2-receptor antagonist were studied in healthy and energy-rich conditions with or without excess NPY. Genetically obese mice overexpressing NPY in brain noradrenergic nerves and SNS (OE-NPYD beta H) represented the situation of elevated NPY levels, while wildtype (WT) mice represented the normal NPY levels. Specific Y-2-receptor antagonist, BIIE0246, was administered (1.3 mg/kg/day, i.p.) for 2 or 4.5 weeks to OE-NPYD beta H and WT mice feeding on chow or Western diet. Treatment with Y-2-receptor antagonist increased body weight gain in both genotypes on chow diet and caused metabolic disturbances (e.g., hyperinsulinemia and hypercholesterolemia), especially in WT mice. During energy surplus (i.e., on Western diet), blocking of Y-2-receptors induced obesity in WT mice, whereas OE-NPYD beta H mice showed reduced fat mass gain, hepatic glycogen and serum cholesterol levels relative to body adiposity. Thus, it can be concluded that with normal NPY levels, peripheral Y-2-receptor antagonist has no potential for treating obesity, but oppositely may even induce metabolic disorders. However, when energy-rich diet is combined with elevated NPY levels, e.g., stress combined with an unhealthy diet, Y-2-receptor antagonism has beneficial effects on metabolic status.
C1 [Ailanen, Liisa; Vahatalo, Laura H.; Salomaki-Myftari, Henriikka; Makela, Satu; Orpana, Wendy; Ruohonen, Suvi T.; Savontaus, Eriika] Univ Turku, Turku Ctr Dis Modeling, Res Ctr Integrat Physiol & Pharmacol, Inst Biomed, Turku, Finland.
   [Ailanen, Liisa; Salomaki-Myftari, Henriikka] Univ Turku, Drug Res Doctoral Program, Turku, Finland.
   [Savontaus, Eriika] Turku Univ Hosp, Clin Pharmacol Unit, Turku, Finland.
C3 University of Turku; University of Turku; University of Turku
RP Savontaus, E (corresponding author), Univ Turku, Turku Ctr Dis Modeling, Res Ctr Integrat Physiol & Pharmacol, Inst Biomed, Turku, Finland.; Savontaus, E (corresponding author), Turku Univ Hosp, Clin Pharmacol Unit, Turku, Finland.
EM eriika.savontaus@utu.fi
RI Ruohonen, Saku/MFI-3214-2025
OI Savontaus, Eriika/0000-0003-3421-0367
FU Academy of Finland [130882, 252441]; Finnish Funding Agency for
   Technology and Innovation [143/31/2010]; Turku University Hospital
   Research Fund [L3826]; Academy of Finland (AKA) [130882] Funding Source:
   Academy of Finland (AKA)
FX This study was financially supported by Academy of Finland (130882 to ES
   and 252441 to SR), the Finnish Funding Agency for Technology and
   Innovation (143/31/2010), and Turku University Hospital Research Fund
   (L3826).
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NR 43
TC 8
Z9 9
U1 0
U2 5
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD APR 5
PY 2018
VL 9
AR 319
DI 10.3389/fphar.2018.00319
PG 11
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA GB7WB
UT WOS:000429284700001
PM 29674968
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Smith, GN
AF Smith, Graeme N.
TI The Maternal Health Clinic: Improving women's cardiovascular health
SO SEMINARS IN PERINATOLOGY
LA English
DT Review
ID METABOLIC SYNDROME; PREGNANCY COMPLICATIONS; DISEASE RISK;
   HEART-DISEASE; LIFE; INTERVENTION; HYPERTENSION; 30-YEAR
AB Women's cardiovascular health is a national priority that should be addressed through improving cardiovascular awareness and prevention. Given the costs of treating cardiovascular disease and screening for it, novel and innovative ways to identify women who should undergo risk screening and intervention, including lifestyle modification, is critical to achieve this goal. Pregnancy is seen as a vascular stress test in that the development of common pregnancy complications has been shown to predict a woman's risk of premature cardiovascular disease and cardiovascular disease-related mortality. Therefore, pregnancy and the postpartum period provide a new early window of opportunity to identify risk factors for the majority of women to improve their long-term health. We have translated the research findings into the Maternal Health Clinic for health maintenance and disease prevention. Women who develop one of the pregnancy-related cardiovascular risk indicators are referred for screening, counseling, and lifestyle modification. We have reported that over half of the women referred to the Maternal Health Clinic, in comparison to women who have a normal pregnancy outcome, have a high lifetime cardiovascular disease risk and three times the risk to meet the criteria for the metabolic syndrome. If these women had not attended our clinic and received early screening and intervention, they may not have been identified as having underlying risk factors until much later in life. Intervening and management later in life, when there is a potentially greater burden of atherosclerosis, does not reduce cardiovascular disease risk to the same extent as maintaining favorable risk factor levels throughout adulthood. Pregnancy complications and the postpartum period are a new early window of opportunity to reliably identify women who should undergo cardiovascular risk screening, and management that may improve subsequent pregnancy outcomes and prevent cardiovascular disease. (C) 2015 Elsevier Inc. All rights reserved.
C1 Queens Univ, Kingston Gen Hosp, Obstet & Gynecol, Kingston, ON K7L 2V7, Canada.
C3 Queens University - Canada; Queens University Hospital
RP Smith, GN (corresponding author), Queens Univ, Kingston Gen Hosp, Obstet & Gynecol, 76 Stuart St, Kingston, ON K7L 2V7, Canada.
EM gns@queensu.ca
RI Smith, Graeme/ABB-6863-2021
OI Smith, Graeme/0000-0002-3128-4523
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NR 28
TC 27
Z9 30
U1 0
U2 6
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0146-0005
EI 1558-075X
J9 SEMIN PERINATOL
JI Semin. Perinatol.
PD JUN
PY 2015
VL 39
IS 4
BP 316
EP 319
DI 10.1053/j.semperi.2015.05.012
PG 4
WC Obstetrics & Gynecology; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology; Pediatrics
GA CP4XD
UT WOS:000359885000012
PM 26077232
DA 2025-06-11
ER

PT J
AU Chen, M
   He, MA
   Min, XW
   Pan, A
   Zhang, XM
   Yao, P
   Li, XL
   Liu, YW
   Yuan, J
   Chen, WH
   Zhou, L
   Fang, WM
   Liang, Y
   Wang, YJ
   Miao, XP
   Lang, MJ
   Zhang, P
   Li, DF
   Guo, H
   Yang, HD
   Hu, FB
   Wu, TC
AF Chen, Mu
   He, Meian
   Min, Xinwen
   Pan, An
   Zhang, Xiaomin
   Yao, Ping
   Li, Xiulou
   Liu, Yuewei
   Yuan, Jing
   Chen, Weihong
   Zhou, Li
   Fang, Weimin
   Liang, Yuan
   Wang, Youjie
   Miao, Xiaoping
   Lang, Mingjian
   Zhang, Peng
   Li, Dongfeng
   Guo, Huan
   Yang, Handong
   Hu, Frank B.
   Wu, Tangchun
TI Different Physical Activity Subtypes and Risk of Metabolic Syndrome in
   Middle-Aged and Older Chinese People
SO PLOS ONE
LA English
DT Article
ID TAI CHI EXERCISE; CARDIOVASCULAR-DISEASE; ADULTS; HEALTH; TRIAL;
   ASSOCIATION; STATEMENT; STRESS; WOMEN
AB Background: The prevalence of metabolic syndrome (MetS) is growing rapidly in China. Tai chi and dancing are common types of exercise among middle-aged and elderly Chinese. It remains unclear whether these activities are associated with a lower risk of MetS.
   Methodology/Principal Findings: A total of 15,514 individuals (6,952 men, 8,562 women) aged 50 to 70 years from the Dongfeng-Tongji Cohort in Shiyan, China participated in a cross-sectional study. Physical activity and other lifestyle factors were assessed with semi-structured questionnaires during face-to-face interviews. MetS was defined by the current National Cholesterol Education Program/Adult treatment Panel III criteria for Asian Americans. The prevalence of MetS was 33.2% in the study population. In the multivariable-adjusted logistic regression analyses, total physical activity levels were monotonically associated with a lower odds of MetS [OR 0.75 comparing extreme quintiles, 95% confidence interval (CI) 0.66-0.86, P<0.001]. Compared with non-exercisers in a specific exercise type, jogging (OR 0.82, 95% CI 0.68-1.00, P = 0.046), tai chi (OR 0.72, 95% CI 0.60-0.88, P<0.001), and dancing (OR 0.56, 95% CI 0.47-0.67, P<0.001) were associated with significantly lower odds of MetS. Furthermore, each 1-h/week increment in tai chi and dancing was associated with a 5% (95% CI 2%-9%) and a 9% (95% CI 6%, 12%) lower risk of MetS.
   Conclusions/Significance: Jogging, tai chi and dancing are associated with a significantly lower risk of having MetS in middle-aged and older Chinese. Future intervention studies should consider the role of jogging, tai chi and dancing in preventing MetS.
C1 [Chen, Mu; He, Meian; Zhang, Xiaomin; Yao, Ping; Liu, Yuewei; Yuan, Jing; Chen, Weihong; Zhou, Li; Fang, Weimin; Liang, Yuan; Wang, Youjie; Miao, Xiaoping; Guo, Huan; Wu, Tangchun] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, MOE Key Lab Environm & Hlth, Wuhan 430074, Hubei, Peoples R China.
   [Chen, Mu; Pan, An; Li, Xiulou; Lang, Mingjian; Hu, Frank B.] Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA.
   [Chen, Mu; Pan, An; Li, Xiulou; Lang, Mingjian; Hu, Frank B.] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.
   [Min, Xinwen; Zhang, Peng; Li, Dongfeng; Yang, Handong] Dongfeng Motor Corp, Dongfeng Cent Hosp, Shiyan, Hubei, Peoples R China.
   [Min, Xinwen; Zhang, Peng; Li, Dongfeng; Yang, Handong] Hubei Univ Med, Shiyan, Hubei, Peoples R China.
C3 Huazhong University of Science & Technology; Harvard University; Harvard
   T.H. Chan School of Public Health; Harvard University; Harvard T.H. Chan
   School of Public Health; Dongfeng Motor; Hubei University of Medicine
RP Hu, FB (corresponding author), Harvard Univ, Sch Publ Hlth, Dept Nutr, 665 Huntington Ave, Boston, MA 02115 USA.
EM frank.hu@channing.harvard.edu; wut@mails.tjmu.edu.cn
RI Zhang, Xiaomin/F-3206-2018; yu, ye/KVB-7532-2024; Zhang,
   Peng/T-8334-2019; li, yan/GXH-7943-2022; Hu, Frank/C-1919-2013; Chen,
   Weihong/D-2177-2011; Liu, Yuewei/J-5147-2019; Pan, An/C-5572-2011; miao,
   xiaoping/C-4336-2011; Chen, Mu/L-8745-2014
OI Liu, Yuewei/0000-0001-5970-4262; Pan, An/0000-0002-1089-7945; Li,
   Dongfeng/0000-0003-2583-1727; Min, Xinwen/0000-0002-8429-6560; miao,
   xiaoping/0000-0002-6818-9722; Chen, Mu/0000-0003-2743-1014
FU Huazhong University of Science and Technology Foundation for Educational
   Development and Research; National Basic Research Program [2011CB503800]
FX This work was supported by Huazhong University of Science and Technology
   Foundation for Educational Development and Research and the National
   Basic Research Program grant 2011CB503800. The funders had no role in
   study design, data collection and analysis, decision to publish, or
   preparation of the manuscript.
CR Ainsworth BE, 2011, MED SCI SPORT EXER, V43, P1575, DOI 10.1249/MSS.0b013e31821ece12
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   Wang F., 2012, International journal of epidemiology
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NR 30
TC 30
Z9 36
U1 0
U2 56
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JAN 7
PY 2013
VL 8
IS 1
AR e53258
DI 10.1371/journal.pone.0053258
PG 7
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Science & Technology - Other Topics
GA 069IS
UT WOS:000313429100046
PM 23308175
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Aeberli, I
   Molinari, L
   Spinas, G
   Lehmann, R
   l'Allemand, D
   Zimmermann, MB
AF Aeberli, Isabelle
   Molinari, Luciano
   Spinas, Giatgen
   Lehmann, Roger
   l'Allemand, Dagmar
   Zimmermann, Michael B.
TI Dietary intakes of fat and antioxidant vitamins are predictors of
   subclinical inflammation in overweight Swiss children
SO AMERICAN JOURNAL OF CLINICAL NUTRITION
LA English
DT Article
DE children; obesity; inflammation; diet; C-reactive protein; interleukin
   6; leptin; tumor necrosis factor alpha; fat; antioxidants
ID C-REACTIVE PROTEIN; TUMOR-NECROSIS-FACTOR; FOR-DISEASE-CONTROL; GRADE
   SYSTEMIC INFLAMMATION; CARDIOVASCULAR RISK-FACTORS; INCREASED OXIDATIVE
   STRESS; INSULIN-RESISTANCE; FACTOR-ALPHA; METABOLIC SYNDROME;
   ACID-COMPOSITION
AB Background: In obese children, subclinical inflammation is often present and is correlated with the metabolic syndrome. Dietary factors, such as fatty acids and antioxidants, potentially modulate the association between adiposity and subclinical inflammation, but few data are available in children.
   Objective: The aim of the study was to determine whether dietary fat or antioxidant intakes influence circulating tumor necrosis factor a (TNF-alpha), interleukin 6 (IL-6), C-reactive protein (CRP), and leptin concentrations in overweight children.
   Design: In a cross-sectional study of 6-14-y-old normal-weight (n = 33), overweight (n = 19), and obese (n = 27) Swiss children, nutritional intakes were assessed from two 24-h dietary recalls and a 1-d dietary record. Percentage body fat from skinfold thicknesses, waist-hip ratio, and blood pressure were measured. Fasting blood samples were collected for the measurement of insulin, glucose, HDL-cholesterol, triacylglycerol, CRP, IL-6, TNF-alpha, and leptin concentrations.
   Results: CRP, IL-6, and leptin increased significantly (P < 0.02) with increasing adiposity, independent of age; TNF-alpha did not increase. Total dietary fat and the percentage of energy from fat were significant predictors of CRP concentration, independent of body mass index (P < 0.05). Meat intake was a significant predictor of IL-6 and leptin, independent of body mass index (P < 0.05). Intakes of antioxidant vitamins (vitamins E and C and beta-carotene) were significant predictors of leptin (P < 0.05) but not of CRP, IL-6, or TNF-alpha.
   Conclusions: Overweight Swiss children as young as 6 y have elevated concentrations of inflammatory markers. Intakes of total fat and antioxidant vitamins are determinants of subclinical inflammation in this age group.
C1 ETH, Inst Food Sci & Nutr, Human Nutr Lab, Swiss Fed Inst Technol, CH-8092 Zurich, Switzerland.
   Univ Zurich, Childrens Hosp, Dept Growth & Dev, Zurich, Switzerland.
   Univ Zurich Hosp, Clin Endocrinol & Diabet, CH-8091 Zurich, Switzerland.
   Childrens Hosp Eastern Switzerland, St Gallen, Switzerland.
C3 Swiss Federal Institutes of Technology Domain; ETH Zurich; University
   Children's Hospital Zurich; University of Zurich; University of Zurich;
   University Zurich Hospital
RP Zimmermann, MB (corresponding author), ETH, Inst Food Sci & Nutr, Human Nutr Lab, Swiss Fed Inst Technol, LFV E19,Schmelzbergstr 7, CH-8092 Zurich, Switzerland.
EM michael.zimmermann@ilw.agrl.ethz.ch
RI Lehmann, Roger/B-9120-2015; Zimmermann, Michael/C-3062-2016;
   Herter-Aeberli, Isabelle/C-8580-2013
OI Herter-Aeberli, Isabelle/0000-0003-0134-6217
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NR 81
TC 97
Z9 113
U1 0
U2 9
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0002-9165
EI 1938-3207
J9 AM J CLIN NUTR
JI Am. J. Clin. Nutr.
PD OCT
PY 2006
VL 84
IS 4
BP 748
EP 755
DI 10.1093/ajcn/84.4.748
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 093AX
UT WOS:000241140700011
PM 17023700
OA Bronze
DA 2025-06-11
ER

PT J
AU Kong, X
   Ma, MZ
   Qin, L
   Zhang, Y
   Li, XY
   Wang, GD
   Su, Q
   Zhang, DY
AF Kong, Xiang
   Ma, Ming-zhe
   Qin, Li
   Zhang, Yan
   Li, Xiao-yong
   Wang, Guo-dong
   Su, Qing
   Zhang, Dao-you
TI Pioglitazone enhances the blood pressure-lowering effect of losartan via
   synergistic attenuation of angiotensin II-induced vasoconstriction
SO JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM
LA English
DT Article
DE Losartan; pioglitazone; endothelial dysfunction; angiotensin II
ID ENDOTHELIUM-DEPENDENT RELAXATION; SPONTANEOUSLY HYPERTENSIVE-RATS;
   REFINED-CARBOHYDRATE DIET; HIGH-SUCROSE DIET; INDUCED
   CARDIAC-HYPERTROPHY; PPAR-GAMMA AGONIST; INSULIN-RESISTANCE; HIGH-FAT;
   METABOLIC SYNDROME; OXIDATIVE STRESS
AB Introduction: This study was designed to investigate the underlying mechanisms of synergistic antihypertensive effect produced by combination therapy of losartan and pioglitazone in metabolic syndrome (MS) rats.
   Materials and methods: An MS model was induced by feeding rats a high-fat, high-sodium diet and 20% sucrose solution. Losartan (20 mg/kg/day), pioglitazone (10 mg/kg/day), and their combination were orally administered for eight consecutive weeks. Systolic blood pressure (SBP) and mean arterial pressure (MAP) were measured using the tail-cuff method and carotid arterial catheterization, respectively. The aortas were isolated and in vitro vascular reactivity studies were performed. The protein expression of angiotensin type 1 receptor (AT(1)), endothelial nitric oxide synthase (eNOS), phosphorylated eNOS and nicotinamide adenine dinucleotide phosphate (NADPH) oxidase subunit p47(phox), level of nitrotyrosine as well as activity of eNOS and NADPH oxidase in aortas of MS rats were detected.
   Results: After eight weeks of treatment, the SBP and MAP in the losartan (115 5 and 106 +/- 6 mmHg), pioglitazone (130 +/- 6 and 118 +/- 6 mmHg), and combination therapy (105 +/- 6 and 98 +/- 5 mmHg) groups were lower than those in the model group (150 +/- 8 and 136 +/- 9 mmHg). Combination therapy of losartan and pioglitazone reduced BP more than either monotherapy, and showed additive effects on improving endothelial dysfunction and abolishing the increased vascular responsiveness to angiotensin II. These synergistic effects were associated with further reductions in protein expression of p47(phox) and AT(1), NADPH oxidase activity, and nitrotyrosine level.
   Conclusions: Our data indicate that combined treatment exerts more beneficial effects on lowering BP and improving vascular lesions.
C1 [Kong, Xiang; Qin, Li; Li, Xiao-yong; Su, Qing] Shanghai Jiao Tong Univ, Sch Med, Xinhua Hosp, Dept Endocrinol, Shanghai 200092, Peoples R China.
   [Kong, Xiang] State Adm Tradit Chinese Med, Wannan Med Coll, Grade Pharmacol Lab 3, Dept Pharmacol, Beijing, Peoples R China.
   [Ma, Ming-zhe] Shanghai Jiao Tong Univ, Sch Med, Xinhua Hosp, Dept Gen Surg, Shanghai 200092, Peoples R China.
   [Zhang, Yan] Wannan Med Coll, Yijishan Hosp, Dept Gastroenterol, Wuhu, Anhui, Peoples R China.
   [Wang, Guo-dong] Wannan Med Coll, Dept Pharm, Wuhu, Anhui, Peoples R China.
   [Zhang, Dao-you] Wannan Med Coll, Yijishan Hosp, Dept Nephrol, Wuhu, Anhui, Peoples R China.
C3 Shanghai Jiao Tong University; Wannan Medical College; Shanghai Jiao
   Tong University; Wannan Medical College; Wannan Medical College; Wannan
   Medical College
RP Su, Q (corresponding author), Shanghai Jiao Tong Univ, Sch Med, Xinhua Hosp, Dept Endocrinol, Kongjiang Rd 1665, Shanghai 200092, Peoples R China.
EM yjszhangdaoyou@sina.com; suqingxinhua@yahoo.com.cn
RI ma, mingzhe/GLR-0560-2022; Wang, Guodong/GWC-3701-2022; Kong,
   Xiang/MTG-6398-2025
OI Wang, Guodong/0000-0003-0398-6373
FU Natural Science Foundation of Education Department of Anhui Province
   [KJ2010B466]; National Natural Science Foundation of China [81000332]
FX This research was supported by the Natural Science Foundation of
   Education Department of Anhui Province (grant number KJ2010B466) and the
   National Natural Science Foundation of China (grant number 81000332).
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NR 58
TC 16
Z9 16
U1 0
U2 13
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1470-3203
EI 1752-8976
J9 J RENIN-ANGIO-ALDO S
JI J. Renin-Angiotensin-Aldosterone Syst.
PD SEP
PY 2014
VL 15
IS 3
BP 259
EP 270
DI 10.1177/1470320313489061
PG 12
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA AQ5DV
UT WOS:000342827100008
PM 23676251
OA hybrid
DA 2025-06-11
ER

PT J
AU Naz, MSG
   Ghasemi, V
   Amirshekari, S
   Tehrani, FR
AF Naz, Marzieh Saei Ghare
   Ghasemi, Vida
   Amirshekari, Shabahang
   Tehrani, Fahimeh Ramezani
TI Polycystic Ovary Syndrome and Irritable Bowel Syndrome: Is There a
   Common Pathway?
SO ENDOCRINOLOGY DIABETES & METABOLISM
LA English
DT Review
DE irritable bowel syndrome; metabolic syndrome; polycystic ovary syndrome;
   review
ID C-REACTIVE PROTEIN; MALE SEX-HORMONES; INCREASED RISK; END-PRODUCTS;
   WOMEN; STRESS; PATHOPHYSIOLOGY; INFLAMMATION; PREGNANCY; SYMPTOMS
AB ObjectiveLittle is known about how polycystic ovary syndrome (PCOS) is linked to irritable bowel syndrome (IBS). This study aimed to review the existing literature regarding the association between PCOS or its symptoms and complications with IBS.MethodsIn this review, studies that investigated the proposed cross-link between features of PCOS and IBS were included. This review collectively focused on recent findings on the mechanism and novel insight regarding the association between IBS and PCOS in future clinical practice. An electronic search of PubMed, Scopus, Epistemonikos, Cochrane Library and Google Scholar was performed. We did not restrict the study setting and publication date.ResultsThe existing evidence has not completely answered the question of whether there is an association between PCOS and IBS and vice versa. Six case-control studies (793 women with PCOS and 547 women in the control group) directly assessed the association between PCOS and IBS. The prevalence of IBS among women with PCOS in these studies has ranged from 10% to 52% compared with 5%-50% in control groups. Evidence suggested the common pathways may have contributed to the interaction between IBS and PCOS, including metabolic syndrome, sex hormone fluctuation, dysregulation of neurotransmitters, psychological problems and environmental and lifestyle factors. To date, it is still ambiguous which of the mentioned components largely contributes to the pathogenesis of both.ConclusionAlthough limited evidence has shown a higher prevalence of IBS in women with PCOS, there are several potential, direct and common indirect pathways contributing to the development of both IBS and PCOS.
   Although limited evidence has shown a higher incidence of IBS in women with PCOS, there are several potential direct and common indirect pathways contributing to the development of both IBS and PCOS.image
C1 [Naz, Marzieh Saei Ghare; Amirshekari, Shabahang; Tehrani, Fahimeh Ramezani] Shahid Beheshti Univ Med Sci, Reprod Endocrinol Res Ctr, Res Inst Endocrine Sci, Tehran, Iran.
   [Ghasemi, Vida] Asadabad Sch Med Sci, Asadabad, Iran.
   [Tehrani, Fahimeh Ramezani] Fdn Res & Educ Excellence, Vestavia Hills, AL 35216 USA.
C3 Shahid Beheshti University Medical Sciences
RP Tehrani, FR (corresponding author), Shahid Beheshti Univ Med Sci, Reprod Endocrinol Res Ctr, Res Inst Endocrine Sci, Tehran, Iran.; Tehrani, FR (corresponding author), Fdn Res & Educ Excellence, Vestavia Hills, AL 35216 USA.
EM framezan@post.harvard.edu
RI Naz, Marzieh/K-8811-2019; ghasemi, vida/K-5490-2018; Tehrani,
   Fahimeh/H-6133-2017
OI Ramezani Tehrani, Fahimeh/0000-0002-4609-065X
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NR 119
TC 1
Z9 1
U1 2
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
EI 2398-9238
J9 ENDOCRIN DIAB METAB
JI Endocrinol. Diabetes Metab.
PD MAR
PY 2024
VL 7
IS 2
AR e00477
DI 10.1002/edm2.477
PG 10
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA LH6O1
UT WOS:001185939300001
PM 38494583
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Tan, Q
   Chen, M
   Hao, J
   Wei, K
AF Tan, Qiang
   Chen, Ming
   Hao, Jia
   Wei, Kun
TI Impact of Hyperinsulinemia on Long-Term Clinical Outcomes of
   Percutaneous Coronary Intervention in Patients without Diabetes Who Have
   Acute Myocardial Syndrome
SO DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
LA English
DT Article
DE percutaneous coronary intervention; hyperinsulinemia; acute myocardial
   syndrome; major adverse cardiac events
ID INSULIN-RESISTANCE; NONDIABETIC PATIENTS; METABOLIC SYNDROME; STRESS
AB Background and Objectives: Hyperinsulinemia plays a key role in the development of cardiovascular impairment in patients with metabolic syndrome. The aim of this study was to evaluate the influence of hyperinsulinemia on long-term clinical outcomes of percutaneous coronary intervention (PCI) in patients without diabetes mellitus who have acute myocardial syndrome (ACS). Methods: Between March 2016 and January 2019, we enrolled 468 patients with ACS and without diabetes mellitus who received primary PCI. Patients were divided into a low-insulin group (n = 157), medium-insulin group (n = 154), and high-insulin group (n = 157) according to tertiles of fasting insulin level. The primary endpoint was major adverse cardiac events (MACE; all-cause death, non-fatal myocardial infarction, target vessel revascularization [TVR]) at 24 months. The secondary endpoint was angina hospitalization. Results: Patients in the high-insulin group had an unfavorable prognosis, with a higher rate of MACE (34.39%) than the low-insulin group (22.29%) and medium-insulin group (23.37%) at 24 months (P < 0.05). This difference was mainly driven by the increase in TVR. The high-insulin group also had a higher rate of angina hospitalization than the low-insulin group. Cox proportional hazards regression showed that high-insulin level (hazard ratio [HR] 1.870, 95% confidence interval [CI] 1.202-2.909), small-vessel lesion (HR 1.713, 95% CI 1.111-2.642), bifurcation lesion (HR 3.394, 95% CI 2.033-5.067), SYNTAX score (HR 1.084, 95% CI 1.039-1.130), and stent length (HR 1.017, 95% CI 1.002-1.032) increased the incidence of MACE in patients with ACS and without diabetes who underwent PCI. Conclusion: Hyperinsulinemia might be a valid predictor of clinical outcomes in patients with ACS undergoing PCI.
C1 [Tan, Qiang; Chen, Ming; Hao, Jia; Wei, Kun] Hebei Med Univ, Qinhuangdao Hosp 1, Dept Cardiol, 258 Wenhua Rd, Qinhuangdao 066000, Hebei, Peoples R China.
C3 Hebei Medical University
RP Tan, Q (corresponding author), Hebei Med Univ, Qinhuangdao Hosp 1, Dept Cardiol, 258 Wenhua Rd, Qinhuangdao 066000, Hebei, Peoples R China.
EM qhdtanqiang@aliyun.com
FU S&T program of Hebei [20377756D]; Hebei Chinese medical technology
   project [2020377]; Hebei medical technology project [20171252]
FX This work was supported by S&T program of Hebei (20377756D) , Hebei
   Chinese medical technology project (2020377) and Hebei medical
   technology project (20171252) .
CR Amer Diabet Assoc, 2010, DIABETES CARE, V33, pS11, DOI [10.2337/dc10-S011, 10.2337/dc10-S062, 10.2337/dc13-S011, 10.2337/dc13-S067, 10.2337/dc11-S011, 10.2337/dc14-S081, 10.2337/dc12-s064, 10.2337/dc11-S062, 10.2337/dc12-s011]
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NR 29
TC 2
Z9 2
U1 0
U2 6
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-7007
J9 DIABET METAB SYND OB
JI Diabetes Metab. Syndr. Obes.
PY 2021
VL 14
BP 3949
EP 3957
DI 10.2147/DMSO.S318852
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA UR7KJ
UT WOS:000696923200007
PM 34522113
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Barquilla, PC
   Pagano, ES
   Jiménez-Ortega, V
   Fernández-Mateos, P
   Esquifino, AI
   Cardinali, DP
AF Cano Barquilla, Pilar
   Pagano, Eleonora S.
   Jimenez-Ortega, Vanesa
   Fernandez-Mateos, Pilar
   Esquifino, Ana I.
   Cardinali, Daniel P.
TI Melatonin normalizes clinical and biochemical parameters of mild
   inflammation in diet-induced metabolic syndrome in rats
SO JOURNAL OF PINEAL RESEARCH
LA English
DT Article
DE cytokines; dyslipidemia; glucose tolerance; high-fat diet; hypertension;
   inflammation; uric acid
ID HIGH-FAT DIET; NF-KAPPA-B; OXIDATIVE STRESS; BODY-WEIGHT; NONALCOHOLIC
   STEATOHEPATITIS; OVARIECTOMIZED RATS; IMMUNE-RESPONSES; LIPID PROFILE;
   DOUBLE-BLIND; OBESITY
AB The objective of this study was to evaluate the efficacy of melatonin to affect mild inflammation in the metabolic syndrome (MS) induced by a high-fat diet in rats. Adult Wistar male rats were divided into four groups (n = 16/group): (i) control diet (3% fat); (ii) high-fat (35%) diet; (iii) high-fat diet + melatonin; and (iv) melatonin. Rats had free access to high-fat or control chow and one of the following drinking solutions for 10 wk: (a) tap water; (b) 25 mu g/mL of melatonin. Plasma interleukin (IL)-1 beta, IL-4, IL-6, IL-10, tumor necrosis factor (TNF)-alpha, interferon (IFN)-gamma, and C-reactive protein (CRP) were measured at two time intervals, that is, the middle of daylight period and the middle of the scotophase. In addition, a number of somatic and metabolic components employed clinically to monitor the MS were measured. Melatonin decreased the augmented circulating levels of IL-1 beta, IL-6, TNF-alpha, IFN-gamma, and CRP seen in obese rats and restored the depressed levels of IL-4 and IL-10. Rats fed with the high-fat diet showed significantly higher body weights and augmented systolic blood pressure from the third and fourth week onwards, respectively, melatonin effectively preventing these changes. In high-fat-fed rats, circulating low-density lipoprotein-cholesterol, total cholesterol, and triglyceride concentration augmented significantly, melatonin being effective to counteract these changes. Melatonin-treated rats showed a decreased insulin resistance, the highest values of plasma high-density lipoprotein-cholesterol, and the lowest values of plasma uric acid. The results indicate that melatonin is able to normalize the altered biochemical pro-inflammatory profile seen in rats fed with a high-fat diet.
C1 [Cano Barquilla, Pilar; Jimenez-Ortega, Vanesa; Esquifino, Ana I.] Univ Complutense, Fac Med, Dept Biochem & Mol Biol 3, E-28040 Madrid, Spain.
   [Pagano, Eleonora S.; Cardinali, Daniel P.] Pontificia Univ Catolica Argentina, Fac Ciencias Med, Dept Docencia & Invest, RA-1107 Buenos Aires, DF, Argentina.
   [Fernandez-Mateos, Pilar] Univ Complutense, Fac Med, Dept Cellular Biol, E-28040 Madrid, Spain.
   [Cardinali, Daniel P.] Univ Buenos Aires, Fac Med, Dept Physiol, Buenos Aires, DF, Argentina.
C3 Complutense University of Madrid; Pontificia Universidad Catolica
   Argentina; Complutense University of Madrid; University of Buenos Aires
RP Cardinali, DP (corresponding author), Pontificia Univ Catolica Argentina, Fac Ciencias Med, Dept Docencia & Invest, Av Alicia Moreau de Justo 1500,4o Piso, RA-1107 Buenos Aires, DF, Argentina.
EM danielcardinali@uca.edu.ar
RI Jimenez Ortega, Vanesa/F-1285-2016; Fernandez-Mateos, Pilar/F-3127-2016;
   Esquifino Parras, Ana Isabel/F-3146-2016; Cano Barquilla,
   Pilar/F-1239-2016
OI Jimenez Ortega, Vanesa/0000-0001-7553-5446; Fernandez-Mateos,
   Pilar/0000-0002-4113-4756; Esquifino Parras, Ana
   Isabel/0000-0002-1625-7615; Cano Barquilla, Pilar/0000-0001-8770-2723
FU Ministerio de Educacion y Ciencia, Spain [SAF2008-00424]; Agencia
   Nacional de Promocion Cientifica y Tecnologica, Argentina [PICT
   2012-0984]; University of Buenos Aires [M 048]; Mutua Madrilena
   Foundation, Madrid, Spain; Eugenio Rodriguez Pascual Foundation, Madrid,
   Spain; Argentine Research Council. (CONICET)
FX This research was supported by grants from Ministerio de Educacion y
   Ciencia, Spain (SAF2008-00424), Agencia Nacional de Promocion Cientifica
   y Tecnologica, Argentina (PICT 2012-0984), University of Buenos Aires (M
   048), and Mutua Madrilena and Eugenio Rodriguez Pascual Foundations,
   Madrid, Spain. ESP and DPC are Research Career Awardees from the
   Argentine Research Council. (CONICET).
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NR 44
TC 55
Z9 55
U1 0
U2 18
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0742-3098
EI 1600-079X
J9 J PINEAL RES
JI J. Pineal Res.
PD OCT
PY 2014
VL 57
IS 3
BP 280
EP 290
DI 10.1111/jpi.12168
PG 11
WC Endocrinology & Metabolism; Neurosciences; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Physiology
GA AP7CF
UT WOS:000342234600005
PM 25113124
OA Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Bays, HE
   Schwartz, S
   Littlejohn, T
   Kerzner, B
   Krauss, RM
   Karpf, DB
   Choi, YJ
   Wang, XY
   Naim, S
   Roberts, BK
AF Bays, Harold E.
   Schwartz, Sherwyn
   Littlejohn, Thomas, III
   Kerzner, Boris
   Krauss, Ronald M.
   Karpf, David B.
   Choi, Yun-Jung
   Wang, Xueyan
   Naim, Sue
   Roberts, Brian K.
TI MBX-8025, A Novel Peroxisome Proliferator Receptor-δ Agonist: Lipid and
   Other Metabolic Effects in Dyslipidemic Overweight Patients Treated with
   and without Atorvastatin
SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Article
ID PPAR-DELTA; REVERSE CHOLESTEROL; OXIDATIVE STRESS; ACTIVATION; FAT
AB Context: Preclinical and clinical studies suggest that peroxisome proliferator-activated receptor (PPAR)-delta agonists favorably affect multiple metabolic parameters that are otherwise proatherogenic, many that are not optimally managed with statins alone.
   Objective: The aim of this study was to evaluate the effects of MBX-8025 (a novel PPAR-delta agonist) on lipid and other metabolic parameters associated with increased atherosclerotic risk, administered alone and in combination with atorvastatin.
   Design and Setting: This was a randomized, double-blind, placebo-controlled, parallel group proof-of-concept study conducted at 30 U.S. research sites.
   Participants: This study evaluated 181 overweight men and women with mixed dyslipidemia.
   Intervention(s): Subjects were administered once daily placebo, atorvastatin 20 mg, or MBX-8025 at 50 or 100 mg alone or combined with atorvastatin for 8 wk.
   Main Outcome Measures: The main efficacy measures included change from baseline in apolipoprotein B-100, lipid levels, high-sensitivity C-reactive protein, and additional metabolic parameters, as well as the effect on the metabolic syndrome and LDL particle size.
   Results: Compared to placebo, MBX-8025 alone and in combination with atorvastatin significantly (P < 0.05) reduced apolipoprotein B-100 20-38%, LDL 18-43%, triglycerides 26-30%, non-high-density lipoprotein cholesterol 18-41%, free fatty acids 16-28%, and high-sensitivity C-reactive protein 43-72%; it raised high-density lipoprotein cholesterol 1-12% and also reduced the number of patients with the metabolic syndrome and a preponderance of small LDL particles. MBX-8025 was safe and generally well-tolerated. MBX-8025 also reduced liver enzyme levels.
   Conclusion: MBX-8025, a novel PPAR-delta agonist, favorably affected multiple metabolic parameters with and without atorvastatin. A more complete understanding of MBX-8025 requires a larger future study. (J Clin Endocrinol Metab 96: 2889-2897, 2011)
C1 [Bays, Harold E.] L MARC Res Ctr, Louisville, KY 40213 USA.
   [Schwartz, Sherwyn] DGD Res, San Antonio, TX 78229 USA.
   [Littlejohn, Thomas, III] Piedmont Med Res Associates, Winston Salem, NC 27103 USA.
   [Kerzner, Boris] Hlth Trends Res, Baltimore, MD 21209 USA.
   [Krauss, Ronald M.] Childrens Hosp, Oakland Res Inst, Oakland, CA 94609 USA.
   [Karpf, David B.; Choi, Yun-Jung; Wang, Xueyan; Naim, Sue; Roberts, Brian K.] Metabolex Inc, Hayward, CA 94545 USA.
   [Karpf, David B.; Roberts, Brian K.] Stanford Univ, Sch Med, Stanford, CA 94305 USA.
C3 L-MARC Research Center; Children's Hospital Los Angeles; Children's
   Hospital Oakland Research Institute; Metabolex, Inc.; Stanford
   University
RP Bays, HE (corresponding author), Louisville Metab & Atherosclerosis Res Ctr, 3288 Illinois Ave, Louisville, KY 40213 USA.
EM HBaysMD@aol.com
RI Bays, Harold/HPF-2871-2023; Krauss, Ronald M./LTD-4078-2024
FU Metabolex
FX Metabolex funded this clinical trial. H. E. B. wrote the first draft of
   this manuscript and has received research grants from Metabolex, as well
   as numerous other pharmaceutical companies. R. M. K. is a member of the
   Metabolex Scientific Advisory Board and the Merck Global Atherosclerosis
   Advisory Board, and is coinventor on a patent for use of ion mobility
   methodology for lipoprotein particle analysis. X. W., Y.-J.C., D. B. K.,
   S.N., and B. K. R. are employees of Metabolex Inc., the sponsor of this
   clinical trial, although D. B. K. was not employed by Metabolex at the
   time of manuscript submission. S. S., T. L., and B. K. have nothing to
   declare.
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NR 24
TC 138
Z9 163
U1 0
U2 8
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0021-972X
EI 1945-7197
J9 J CLIN ENDOCR METAB
JI J. Clin. Endocrinol. Metab.
PD SEP
PY 2011
VL 96
IS 9
BP 2889
EP 2897
DI 10.1210/jc.2011-1061
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 815VR
UT WOS:000294558600063
PM 21752880
OA Bronze
DA 2025-06-11
ER

PT J
AU Hsieh, PS
   Tsai, HC
   Kuo, CH
   Chan, JYH
   Shyu, JF
   Cheng, WT
   Liu, TT
AF Hsieh, P-S.
   Tsai, H-C.
   Kuo, C-H.
   Chan, J. Y-H.
   Shyu, J-F.
   Cheng, W-T.
   Liu, T-T.
TI Selective COX2 inhibition improves whole body and muscular insulin
   resistance in fructose-fed rats
SO EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
LA English
DT Article
DE Cyclooxygenase 1 inhibitor; cyclooxygenase 2 inhibitor; fructose;
   insulin resistance; rats
ID NONSELECTIVE CYCLOOXYGENASE-2 INHIBITORS; TYPE-2 DIABETES-MELLITUS;
   GLUCOSE-METABOLISM; GLYCOGEN-SYNTHESIS; OXIDATIVE STRESS; DEPENDENT
   MANNER; MUSCLE; HYPERTENSION; CELECOXIB; INFLAMMATION
AB Background The effects of cyclooxygenase-1 (COX1) and cyclooxygenase-2 (COX2) inhibition on insulin resistance in subjects with the metabolic syndrome remain elusive. Aims of this study were to examine the effects of COX1 and COX2 inhibitors on whole body and muscular insulin resistance in fructose-fed rats, an animal model of the metabolic syndrome.
   Materials and methods The rats on regular or 60% fructose-enriched diets for 6 weeks were further divided into rats combined with or without piroxicam (a selective COX1 inhibitor) or celecoxib (a selective COX2 inhibitor) treatment for an additional 2 weeks. Euglycaemic hyperinsulinaemic clamp (EHC) with a tracer dilution method was performed at the end of the study.
   Results The present result showed that fructose-induced increases in systolic blood pressure and fasting plasma insulin levels were significantly suppressed in rats treated with celecoxib but not piroxicam. In the EHC period, celecoxib significantly reversed fructose-induced decreases in whole body glucose uptake, mainly by glucose storage. Hepatic glucose production and whole body glycolysis were not significantly changed among groups. Celecoxib but not piroxicam significantly reversed fructose-induced decreases in glycogen synthase activities in red and white quadriceps muscles and insulin-stimulated membrane GLUT4 recruitment in soleus muscles. Celecoxib and piroxicam both significantly diminished fructose-induced increases in plasma thromboxane B2 and 6-keto prostaglandin (PG) F1 alpha; but only celecoxib treatment significantly attenuated a fructose-induced increase in 8-isoprostane levels. Plasma PGE metabolites were not different among groups.
   Conclusions This study demonstrates that a therapeutic dose of celecoxib, but not piroxicam, could significantly attenuate fructose-induced whole body and muscular insulin resistance in rats.
C1 [Hsieh, P-S.; Tsai, H-C.] Natl Def Med Ctr, Dept Physiol & Biophys, Taipei 114, Taiwan.
   [Kuo, C-H.] Taipei Phys Educ Coll, Dept Dance, Taipei, Taiwan.
   [Kuo, C-H.] Taipei Phys Educ Coll, Lab Exercise Biochem, Taipei, Taiwan.
   [Chan, J. Y-H.] Natl Def Med Ctr, Grad Inst Med Sci, Taipei 114, Taiwan.
   [Shyu, J-F.] Natl Def Med Ctr, Dept Biol & Anat, Taipei 114, Taiwan.
   [Cheng, W-T.] SongShan Army Forces Gen Hosp, Radiol Sect, Taipei, Taiwan.
   [Liu, T-T.] Hualien Army Force Hosp, Dept Family & Commun, Hualien, Taiwan.
C3 National Defense Medical Center; University of Taipei; Taipei Physical
   Education College; University of Taipei; Taipei Physical Education
   College; National Defense Medical Center; National Defense Medical
   Center
RP Hsieh, PS (corresponding author), Natl Def Med Ctr, Dept Physiol & Biophys, 161,Sect 6,Min Chuan E Rd, Taipei 114, Taiwan.
EM pshsieh@hotmail.com
RI Kuo, Chin-Sung/JCE-4770-2023; Hsieh, Po-Shiuan/AAF-4173-2020
OI Kuo, Chia-Hua/0000-0002-1731-4984
FU National Science Council of the R.O.C. [NSC94-2320-B-016-021,
   NSC95-2320-B-016-012-MY3]
FX The author appreciates the supports from the National Science Council of
   the R.O.C. under grants of NSC94-2320-B-016-021 and
   NSC95-2320-B-016-012-MY3. The author also gratefully acknowledges the
   research assistance of Ms Yueh-Mei Chung, MS.
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NR 34
TC 20
Z9 26
U1 0
U2 4
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0014-2972
J9 EUR J CLIN INVEST
JI Eur. J. Clin. Invest.
PD NOV
PY 2008
VL 38
IS 11
BP 812
EP 819
DI 10.1111/j.1365-2362.2008.02026.x
PG 8
WC Medicine, General & Internal; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Research & Experimental Medicine
GA 363GE
UT WOS:000260255000004
PM 19021698
DA 2025-06-11
ER

PT J
AU Sánchez-Lozada, LG
   Madero, M
   Mazzali, M
   Feig, D
   Nakagawa, T
   Lanaspa, MA
   Kanbay, M
   Kuwabara, M
   Rodriguez-Iturbe, B
   Johnson, RJ
AF Sanchez-Lozada, Laura G.
   Madero, Magdalena
   Mazzali, Marilda
   Feig, Daniel, I
   Nakagawa, Takahiko
   Lanaspa, Miguel A.
   Kanbay, Mehmet
   Kuwabara, Masanari
   Rodriguez-Iturbe, Bernardo
   Johnson, Richard J.
TI Sugar, salt, immunity and the cause of primary hypertension
SO CLINICAL KIDNEY JOURNAL
LA English
DT Review
DE autoimmune; fructose; hypertension; leptin; uric acid; vasopressin
ID ENDOGENOUS FRUCTOSE PRODUCTION; NITRIC-OXIDE DEFICIENCY; SERUM URATE
   LEVELS; URIC-ACID; BLOOD-PRESSURE; ANGIOTENSIN-II; OXIDATIVE STRESS;
   METABOLIC SYNDROME; SENSITIVE HYPERTENSION; GLOMERULAR HYPERTENSION
AB Despite its discovery more than 150 years ago, the cause of primary hypertension remains unknown. Most studies suggest that hypertension involves genetic, congenital or acquired risk factors that result in a relative inability of the kidney to excrete salt (sodium chloride) in the kidneys. Here we review recent studies that suggest there may be two phases, with an initial phase driven by renal vasoconstriction that causes low-grade ischemia to the kidney, followed by the infiltration of immune cells that leads to a local autoimmune reaction that maintains the renal vasoconstriction. Evidence suggests that multiple mechanisms could trigger the initial renal vasoconstriction, but one way may involve fructose that is provided in the diet (such as from table sugar or high fructose corn syrup) or produced endogenously. The fructose metabolism increases intracellular uric acid, which recruits NADPH oxidase to the mitochondria while inhibiting AMP-activated protein kinase. A drop in intracellular ATP level occurs, triggering a survival response. Leptin levels rise, triggering activation of the sympathetic central nervous system, while vasopressin levels rise, causing vasoconstriction in its own right and stimulating aldosterone production via the vasopressin 1b receptor. Low-grade renal injury and autoimmune-mediated inflammation occur. High-salt diets can amplify this process by raising osmolality and triggering more fructose production. Thus, primary hypertension may result from the overactivation of a survival response triggered by fructose metabolism. Restricting salt and sugar and hydrating with ample water may be helpful in the prevention of primary hypertension.
   Lay Summary Here we discuss recent studies that suggest that fructose, present in added sugars, may have a role in primary hypertension. These studies help link the association of obesity and metabolic syndrome with high blood pressure, and the interaction of salt and sugar in causing high blood pressure.
C1 [Sanchez-Lozada, Laura G.] Inst Nacl Cardiol Ignacio Chavez, Dept Cardiorenal Physiopathol, Mexico City, Mexico.
   [Madero, Magdalena] Inst Nacl Cardiol Ignacio Chavez, Div Nephrol, Dept Med, Mexico City, Mexico.
   [Mazzali, Marilda] Univ Estadual Campinas, Div Nephrol, Sao Paulo, Brazil.
   [Feig, Daniel, I] Univ Alabama Birmingham, Div Pediat Nephrol, Birmingham, AL USA.
   [Nakagawa, Takahiko] Rakuwakai Otowa Hosp, Dept Nephrol, Kyoto, Japan.
   [Lanaspa, Miguel A.; Johnson, Richard J.] Univ Colorado, Dept Med, Anschutz Med Ctr, Aurora, CO 80045 USA.
   [Kanbay, Mehmet] Koc Univ, Dept Med, Sch Med, Istanbul, Turkiye.
   [Kuwabara, Masanari] Toranomon Gen Hosp, Depart Cardiol, Tokyo, Japan.
   [Rodriguez-Iturbe, Bernardo] Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Nephrol & Mineral Metab, Mexico City, Mexico.
C3 National Institute of Cardiology - Mexico; National Institute of
   Cardiology - Mexico; Universidade Estadual de Campinas; University of
   Alabama System; University of Alabama Birmingham; University of Colorado
   System; University of Colorado Anschutz Medical Campus; Koc University;
   Toranomon Hospital; Instituto Nacional de Ciencias Medicas y Nutricion
   Salvador Zubiran - Mexico
RP Johnson, RJ (corresponding author), Univ Colorado, Dept Med, Anschutz Med Ctr, Aurora, CO 80045 USA.
EM RICHARD.JOHNSON@CUANSCHUTZ.EDU
RI Sanchez-Lozada, Laura/AAS-2104-2021; 1, 1/IAO-4606-2023; Mazzali,
   Marilda/I-4186-2013; Lanaspa, Miguel/AAO-4971-2020; Rodriguez-Iturbe,
   Bernardo/KFX-2910-2024; Kuwabara, Masanari/O-9844-2017
OI Feig, Daniel/0000-0002-0017-6335; Kuwabara,
   Masanari/0000-0002-6601-4347; Kanbay, Mehmet/0000-0002-1297-0675
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NR 118
TC 5
Z9 6
U1 2
U2 24
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 2048-8505
EI 2048-8513
J9 CLIN KIDNEY J
JI Clin. Kidney J.
PD JUL 31
PY 2023
VL 16
IS 8
BP 1239
EP 1248
DI 10.1093/ckj/sfad058
EA MAY 2023
PG 10
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA N9CH9
UT WOS:000983934800001
PM 37529651
OA gold
DA 2025-06-11
ER

PT J
AU Yang, X
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   Pan, XF
AF Yang, Xue
   Xue, Qingping
   Wen, Ying
   Huang, Yichao
   Wang, Yi
   Mahai, Gaga
   Yan, Tong
   Liu, Yanjun
   Rong, Tao
   Wang, Yixin
   Chen, Da
   Zeng, Shuqin
   Yang, Chun-Xia
   Pan, Xiong-Fei
TI Environmental polycyclic aromatic hydrocarbon exposure in relation to
   metabolic syndrome in US adults
SO SCIENCE OF THE TOTAL ENVIRONMENT
LA English
DT Article
DE PAH; MetS; Epidemiology; Environmental endocrine disruptor; NHANES
ID NUTRITION EXAMINATION SURVEY; CARDIOVASCULAR-DISEASE; OXIDATIVE STRESS;
   NATIONAL-HEALTH; ASSOCIATION; POPULATION; BIOMARKERS; BLOOD; PREVALENCE;
   URINE
AB The present study examined the associations of polycyclic aromatic hydrocarbon (PAH) exposure with metabolic syndrome (MetS) and its components. Data were from 5181 US adults recruited in the National Health and Nutrition Examine Survey 2001-2012. Environmental PAH exposure was estimated as concentrations of urinary PAH metabolites. Weighted quantile sum (WQS) regression and modified Poisson regression were separately conducted to estimate the associations of mixed and single PAH metabolites with MetS and its components. WQS regression analyses showed that participants with higher mixed PAH exposure had increased prevalence of MetS (prevalence ratio, 1.12; 95 % confidence interval, 1.06, 1.19), elevated waist circumference (1.07; 1.02, 1.12), elevated fasting blood glucose (1.07; 1.00, 1.14), elevated triglycerides (1.19; 1.09, 1.30), and reduced high-density lipoprotein cholesterol (1.11; 1.03, 1.20). In the models for single PAH metabolites, higher levels of 1-hydroxynaphthalene (1.15; 1.00, 1.32), 2hydroxynaphthalene (1.20; 1.05, 1.38), 1-hydroxyphenanthrene (1.18; 1.04, 1.34), 2-hydroxyphenanthrene (1.38; 1.22, 1.57), and 1-pyrene (1.19; 1.05, 1.34) were respectively associated with increased prevalence of MetS (highest tertile vs lowest tertile). In addition, linear trends were noted for the associations of these PAH metabolites with MetS (all P for linear association <0.047). Smokers, drinkers, and participants with poor diet quality showed stronger associations between certain PAH metabolite with MetS. The findings suggest that the prevalence of MetS and its components increases when PAH exposure is at a high level, and that lifestyle factors, such as cigarette smoking, alcohol consumption, and diet quality, could modify the positive associations of certain PAH exposure with MetS.
C1 [Yang, Xue; Yang, Chun-Xia] Sichuan Univ, West China Sch Publ Hlth, Dept Epidemiol & Biostat, Chengdu, Sichuan, Peoples R China.
   [Yang, Xue; Yang, Chun-Xia] Sichuan Univ, Noncommunicable Dis Res Ctr, West China PUMC CC Chen Inst Hlth, Chengdu, Sichuan, Peoples R China.
   [Yang, Xue; Zeng, Shuqin; Pan, Xiong-Fei] Sichuan Univ, West China Second Univ Hosp, Key Lab Birth Defects & Related Dis Women & Childr, Minist Educ, Chengdu, Sichuan, Peoples R China.
   [Yang, Xue; Pan, Xiong-Fei] Shuangliu Maternal & Child Hlth Hosp, Shuangliu Inst Womens & Childrens Hlth, Chengdu, Sichuan, Peoples R China.
   [Xue, Qingping] Chengdu Med Coll, Sch Publ Hlth, Dept Epidemiol & Biostat, Chengdu, Sichuan, Peoples R China.
   [Wen, Ying] Shenzhen Ctr Dis Control & Prevent, Shenzhen, Guangdong, Peoples R China.
   [Huang, Yichao] Anhui Med Univ, Sch Publ Hlth, Dept Toxicol, Hefei, Peoples R China.
   [Wang, Yi] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Dept Epidemiol & Biostat, Wuhan, Hubei, Peoples R China.
   [Mahai, Gaga] Huazhong Univ Sci & Technol, Key Lab Environm & Hlth, Minist Educ, Wuhan, Hubei, Peoples R China.
   [Yan, Tong; Liu, Yanjun] Southwest Jiaotong Univ, Peoples Hosp Chengdu 3, Ctr Obes & Metab Hlth, Chengdu, Sichuan, Peoples R China.
   [Liu, Yanjun] Southwest Jiaotong Univ, Peoples Hosp Chengdu 3, Ctr Gastrointestinal & Minimally Invas Surg, Dept Gen Surg, Chengdu, Sichuan, Peoples R China.
   [Rong, Tao] Southwest Jiaotong Univ, Peoples Hosp Chengdu 3, Dept Endocrinol & Metab, Chengdu, Sichuan, Peoples R China.
   [Wang, Yixin] Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA.
   [Chen, Da] Jinan Univ, Sch Environm, Guangzhou, Guangdong, Peoples R China.
   [Pan, Xiong-Fei] Sichuan Univ, West China Univ Hosp 2, 3-17 Renmin Nanlu, Chengdu 610041, Sichuan, Peoples R China.
C3 Sichuan University; Sichuan University; Sichuan University; Ministry of
   Education - China; Chengdu Medical College; Shenzhen Center for Disease
   Control & Prevention (SZCDC); Anhui Medical University; Huazhong
   University of Science & Technology; Huazhong University of Science &
   Technology; Ministry of Education - China; Southwest Jiaotong
   University; Southwest Jiaotong University; Southwest Jiaotong
   University; Harvard University; Harvard T.H. Chan School of Public
   Health; Jinan University; Sichuan University
RP Pan, XF (corresponding author), Sichuan Univ, West China Univ Hosp 2, 3-17 Renmin Nanlu, Chengdu 610041, Sichuan, Peoples R China.
EM pxiongfei@gmail.com
RI Yang, Xue/HGA-1701-2022; Yan, Ethan/HLX-7469-2023; chen,
   da/KUD-2238-2024; Wang, Yixin/AAI-2758-2021; Zhang,
   Youyou/KCY-0810-2024; Pan, Xiongfei/G-7882-2011; Mahai,
   Gaga/AGW-7312-2022
OI Pan, XiongFei/0009-0003-4417-2488; Wang, Yi/0000-0001-6965-9696; Mahai,
   Gaga/0000-0001-9846-9357; Huang, Yichao/0000-0003-1186-1300; Wang,
   Yi-Xin/0000-0003-4324-2408
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NR 46
TC 29
Z9 32
U1 4
U2 37
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0048-9697
EI 1879-1026
J9 SCI TOTAL ENVIRON
JI Sci. Total Environ.
PD SEP 20
PY 2022
VL 840
AR 156673
DI 10.1016/j.scitotenv.2022.156673
PG 9
WC Environmental Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology
GA 2L4OP
UT WOS:000816997600006
PM 35700788
DA 2025-06-11
ER

PT J
AU Ambrosino, P
   Lupoli, R
   Di Minno, A
   Nardo, A
   Marrone, E
   Lupoli, V
   Scaravilli, A
   Mitidieri, E
   Tufano, A
   Di Minno, MND
AF Ambrosino, Pasquale
   Lupoli, Roberta
   Di Minno, Alessandro
   Nardo, Assunta
   Marrone, Emiliana
   Lupoli, Valentina
   Scaravilli, Alessandra
   Mitidieri, Emma
   Tufano, Antonella
   Di Minno, Matteo Nicola Dario
TI Cyclic supplementation of 5-MTHF is effective for the correction of
   hyperhomocysteinemia
SO NUTRITION RESEARCH
LA English
DT Article
DE Homocysteine; Hyperhomocysteinemia; Folate; 5-Methyl-tetra-hydro-folate;
   Cyclic folate supplementation; Patient
ID FOLIC-ACID SUPPLEMENTATION; PLASMA HOMOCYSTEINE CONCENTRATIONS;
   MYOCARDIAL-INFARCTION; RISK-FACTOR; CARDIOVASCULAR EVENTS;
   VASCULAR-DISEASE; OXIDATIVE STRESS; VENOUS THROMBOEMBOLISM;
   HEALTHY-SUBJECTS; UNITED-STATES
AB Folic acid supplementation is the mainstay treatment of hyperhomocysteinemia (HHcy). However, no recommendations are currently available in regard to the optimal replacement therapy. Therefore, this prospective study hypothesized that a cyclic schedule (1 month of therapy followed by 2 months of withdrawal) of 5-methyltetrahydrofolate (5-MTHF) would reduce plasma levels of fasting total homocysteine (tHcy) in patients with mild/moderate HHcy. Patients with a new diagnosis of mild/moderate HHcy were evaluated for the methylenetetrahydrofolate reductase genotype and the presence of major features of metabolic syndrome. All enrolled subjects received a cyclic 5-MTHF oral supplementation and were reevaluated after each treatment cycle for a total of 2 years. In the 246 enrolled subjects, a significant reduction of tHcy levels occurred after the first cycle of treatment (from 31.6 +/- 13.6 to 14.4 +/- 5.77 mu mol/L, P < .001) and during the whole 2-year follow-up (from 31.6 +/- 13.6 to 12.18 +/- 3.03 mu mol/L, P < .001). The values of tHcy returned to reference range in 117 subjects (51.3%) after the first cycle and in 198 (86.8%) during the follow-up. The risk of failure in tHcy level normalization was increased in patients with metabolic syndrome (hazard ratio [HA], 3.49; 95% confidence interval [CI], 1.46-8.36), higher baseline tHcy levels (HR, 1.045; 95% CI, 1.018-1.073), or methylenetetrahydrofolate reductase homozygous mutation (HR, 6.59; 95% CI, 2.64-16.4). This study clearly shows that a cyclic schedule (1 month of therapy followed by 2 months of withdrawal) of 5-MTHF supplementation is able to significantly reduce tHcy levels in patients with mild/moderate HHcy. (C) 2015 Elsevier Inc. All rights reserved.
C1 [Ambrosino, Pasquale; Lupoli, Roberta; Nardo, Assunta; Marrone, Emiliana; Scaravilli, Alessandra; Tufano, Antonella] Univ Naples Federico II, Dept Clin Med & Surg, Naples, Italy.
   [Di Minno, Alessandro; Di Minno, Matteo Nicola Dario] IRCCS, Ctr Cardiol Monzino, Unit Cell & Mol Biol Cardiovasc Dis, I-20138 Milan, Italy.
   [Lupoli, Valentina; Mitidieri, Emma] Univ Naples Federico II, Dept Pharm, Naples, Italy.
C3 University of Naples Federico II; IRCCS Centro Cardiologico Monzino;
   University of Naples Federico II
RP Di Minno, MND (corresponding author), IRCCS, Ctr Cardiol Monzino, Unit Cell & Mol Biol Cardiovasc Dis, Via C Parea 4, I-20138 Milan, Italy.
EM dario.diminno@hotmail.it
RI Di Minno, Matteo/D-5141-2012; Lupoli, Roberta/K-9880-2016; Ambrosino,
   Pasquale/AAD-1934-2020; Di Minno, Alessandro/K-1948-2016; TUFANO,
   Antonella/AHD-0570-2022
OI Di Minno, Matteo/0000-0001-8059-3819; Lupoli,
   Roberta/0000-0002-1701-7197; Ambrosino, Pasquale/0000-0002-9398-0428; Di
   Minno, Alessandro/0000-0001-8084-9976; TUFANO,
   Antonella/0000-0003-2398-6135; Scaravilli,
   Alessandra/0000-0001-6375-5783
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NR 59
TC 9
Z9 10
U1 0
U2 7
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0271-5317
J9 NUTR RES
JI Nutr. Res.
PD JUN
PY 2015
VL 35
IS 6
BP 489
EP 495
DI 10.1016/j.nutres.2015.02.006
PG 7
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA CL0PA
UT WOS:000356643400004
PM 25841618
DA 2025-06-11
ER

PT J
AU Smith, CE
   Arnett, DK
   Tsai, MY
   Lai, CQ
   Parnell, LD
   Shen, J
   Laclaustra, M
   Junyent, M
   Ordovás, JM
AF Smith, Caren E.
   Arnett, Donna K.
   Tsai, Michael Y.
   Lai, Chao-Qiang
   Parnell, Laurence D.
   Shen, Jian
   Laclaustra, Martin
   Junyent, Mireia
   Ordovas, Jose M.
TI Physical inactivity interacts with an endothelial lipase polymorphism to
   modulate high density lipoprotein cholesterol in the GOLDN study
SO ATHEROSCLEROSIS
LA English
DT Article
DE LIPG; Endothelial lipase; HDL; Television; Physical activity
ID SHEAR-STRESS; METABOLIC SYNDROME; EXERCISE; FAMILY; GENE; ASSOCIATION;
   EXPRESSION; ATHEROSCLEROSIS; SUBFRACTIONS; INFLAMMATION
AB Background: Plasma high density lipoprotein (HDL) cholesterol (HDL-C) concentration is highly heritable but is also modifiable by environmental factors including physical activity. HDL-C response to exercise varies among individuals, and this variability may be associated with genetic polymorphisms in the key regulators of HDL metabolism including endothelial lipase (LIPG).
   Methods: We examined associations between variants LIPG T111I (rs2000813) and LIPG i24582 (rs6507931), HDL and television viewing/computer use ("screen time") as a marker for physical inactivity in a population with high prevalence of metabolic syndrome. Subjects consisted of 539 White men and 584 women (mean +/- S. D., 49 +/- 16 years) participating in the GOLDN study.
   Results: We did not observe an association with either LIPG SNP or HDL independently of screen time. In multi-adjusted linear regression models, HDL interacted significantly with screen time as a continuous variable in LIPG i24582 subjects with TT genotype (P < 0.05). By dichotomizing screen time into high and low levels, we found significant genotype-associated differences in HDL in women but not men. When screen time was >= 2.6 h/day, the concentrations of total HDL-C, large HDL, large low density lipoprotein (LDL) were lower, the concentration of small LDL was higher and HDL and LDL particle sizes were smaller in subjects with LIPG i24582 TT compared to CT and CC subjects (P < 0.05).
   Conclusions: We found a significant gene-physical inactivity interaction for HDL and some LDL measures for the LIPG i24582 polymorphism. Higher levels of physical activity may be protective for HDL-C concentrations and low activity detrimental in LIPG i24582 TT individuals, especially in women. (C) 2009 Published by Elsevier Ireland Ltd.
C1 [Ordovas, Jose M.] Tufts Univ, HNRCA, Jean Mayer USDA, Nutr & Genom Lab, Boston, MA 02111 USA.
   [Arnett, Donna K.] Univ Alabama, Dept Epidemiol, Birmingham, AL 35209 USA.
   [Tsai, Michael Y.] Univ Minnesota, Dept Lab Med & Pathol, Minneapolis, MN 55455 USA.
   [Laclaustra, Martin; Ordovas, Jose M.] CNIC, Madrid, Spain.
C3 United States Department of Agriculture (USDA); Tufts University;
   University of Alabama System; University of Alabama Birmingham;
   University of Minnesota System; University of Minnesota Twin Cities;
   Centro Nacional de Investigaciones Cardiovasculares (CNIC)
RP Ordovás, JM (corresponding author), Tufts Univ, HNRCA, Jean Mayer USDA, Nutr & Genom Lab, 711 Washington St, Boston, MA 02111 USA.
EM jose.ordovas@tufts.edu
RI Ordovas, Jose/B-8727-2013; Laclaustra, Martin/C-6709-2015
OI Ordovas, Jose/0000-0002-7581-5680; Arnett, Donna/0000-0003-2219-657X;
   Laclaustra, Martin/0000-0003-3963-0846; Lai,
   Chao-Qiang/0000-0003-1107-8375; Tsai, Michael/0000-0001-7553-3408
FU National Institutes of Health, National Institute on Aging
   [5P01AG023394-02]; NIH/NHLBI [HL54776]; NIH/NIDDK [DK075030]; U.S.
   Department of Agriculture Research Service [53-K06-5-10, 58-1950-9-001];
   Fulbright-Spanish Ministry of Education and Science;  [T32 DK007651-19]
FX Funding: Supported by the National Institutes of Health, National
   Institute on Aging, Grant Number 5P01AG023394-02 and NIH/NHLBI grant
   number HL54776 and NIH/NIDDK DK075030 and contracts 53-K06-5-10 and
   58-1950-9-001 from the U.S. Department of Agriculture Research Service.
   MJ is supported by a grant from the Fulbright-Spanish Ministry of
   Education and Science (reference 2007-1086). C. Smith is supported by
   T32 DK007651-19.
CR Badellino KO, 2008, CIRCULATION, V117, P678, DOI 10.1161/CIRCULATIONAHA.107.707349
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NR 31
TC 34
Z9 36
U1 0
U2 5
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0021-9150
EI 1879-1484
J9 ATHEROSCLEROSIS
JI Atherosclerosis
PD OCT
PY 2009
VL 206
IS 2
BP 500
EP 504
DI 10.1016/j.atherosclerosis.2009.03.012
PG 5
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 512XY
UT WOS:000271287000032
PM 19380136
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Rodríguez-Mortera, R
   Luevano-Contreras, C
   Solorio-Meza, S
   Caccavello, R
   Bains, Y
   Garay-Sevilla, ME
   Gugliucci, A
AF Rodriguez-Mortera, Reyna
   Luevano-Contreras, Claudia
   Solorio-Meza, Sergio
   Caccavello, Russell
   Bains, Yasmin
   Garay-Sevilla, Ma Eugenia
   Gugliucci, Alejandro
TI Higher D-lactate levels are associated with higher prevalence of small
   dense low-density lipoprotein in obese adolescents
SO CLINICAL CHEMISTRY AND LABORATORY MEDICINE
LA English
DT Article
DE atherosclerosis; carotid intima media thickness (CIMT); D-lactate;
   flow-mediated dilation (FMD); insulin-resistance; LDL subclasses;
   metabolic syndrome; methylglyoxal; obesity
ID INTIMA-MEDIA THICKNESS; CARDIOVASCULAR RISK-FACTORS; ISOCALORIC FRUCTOSE
   RESTRICTION; LDL PARTICLE-SIZE; METABOLIC SYNDROME; ENDOTHELIAL
   FUNCTION; CHILDHOOD OBESITY; DICARBONYL STRESS; CHILDREN;
   ATHEROSCLEROSIS
AB Background: Childhood obesity is associated with insulin resistance (IR), increased levels of small dense low-density lipoprotein (sd-LDL) as well as with augmented hepatic de novo lipogenesis, which implies increased triose phosphate fluxes that may lead to increased methylglyoxal (MG) and its catabolic end product D-lactate. We hypothesized that obese adolescents have increased D-lactate serum levels associated with high incidence of sd-LDL.
   Methods: This is a cross-sectional study where the anthropometric characteristics, atherogenic dyslipidemia complex, sd-LDL (Lipoprint, Quantimetrix) and D-lactate (kinetic enzymatic analysis) were explored in 30 lean vs. 30 obese adolescents (16 females and 14 males per group) without metabolic syndrome (MetS). Endothelial function by flow-mediated dilation (FMD, by ultrasound) and arterial lesion by carotid intima media thickness (CIMT, by ultrasound) were also measured.
   Results: The mean age of participants was 16.8 +/- 1.4 years. Obese adolescents had a body mass index of 32.7 +/- 3.8 vs. 21.8 +/- 2.1 in lean participants. The obesity group showed higher D-lactate levels: 6.2 +/- 3.0 vs. 4.5 +/- 2.5 mu mol/L, higher levels of insulin: 15 (9.6-23.5) vs. 7.9 (6.5-10.5) mu IU/mL; triglyceride (TG): 1.46 (1.1-1.8) vs. 0.84 (0.6-1.2) mmol/L; non-high-density lipoprotein-cholesterol (NON-HDL-C): 2.8 +/- 0.9 vs. 2.3 +/- 0.7 mmol/L; total cholesterol (TC)/HDL-C) index: 2.9 +/- 0.7 vs. 2.4 +/- 0.5; TG/HDL-C index: 2.2 (1.5-2.8) vs. 1.1 (0.8-1.8); %LDL-3: 4.2 +/- 4.07 vs. 1.9 +/- 2.7; smaller LDL size: 270.6 +/- 3 vs. 272.2 +/- 1.1 angstrom. D-lactate correlated positively with LDL-2: r = 0.44 and LDL-3 (sd-LDL): r = 0.49 and negatively with large LDL-1: r = -0.48 and LDL size: r = -0.46; (p<0.05, p<0.01, p<0.001 and p<0.0001, respectively). Obese adolescents showed higher CIMT: 0.51 +/- 0.08 vs. 0.46 +/- 0.08 mm and lower FMD: 20.3% +/- 6.7% vs. 26.0% +/- 9.3%.
   Conclusions: Obese adolescents display subclinical signs of IR and endothelial dysfunction. Higher serum sd-LDL levels correlated positively with D-lactate levels. These findings suggest an association between atherogenic dyslipoproteinemia and whole body MG fluxes already detectable in apparently healthy obese adolescents.
C1 [Gugliucci, Alejandro] Touro Univ Calif, Res, 1310 Club Dr, Vallejo, CA 94592 USA.
   [Rodriguez-Mortera, Reyna; Caccavello, Russell; Bains, Yasmin; Gugliucci, Alejandro] Touro Univ, Coll Osteopath Med, Dept Res, Glycat Oxidat & Dis Lab, Vallejo, CA 94592 USA.
   [Rodriguez-Mortera, Reyna; Luevano-Contreras, Claudia; Garay-Sevilla, Ma Eugenia] Univ Guanajuato, Dept Med Sci, Guanajuato, Mexico.
   [Solorio-Meza, Sergio] Mexican Inst Social Secur, Mexico City, DF, Mexico.
C3 Touro University California; Touro University California; Universidad de
   Guanajuato; Instituto Mexicano del Seguro Social
RP Gugliucci, A (corresponding author), Touro Univ Calif, Res, 1310 Club Dr, Vallejo, CA 94592 USA.; Gugliucci, A (corresponding author), Touro Univ, Coll Osteopath Med, Dept Res, Glycat Oxidat & Dis Lab, Vallejo, CA 94592 USA.
EM alejandro.gugliucci@tu.edu
RI Rodríguez-Mortera, Reyna/H-1727-2011; Luevano-Contreras,
   Claudia/ADJ-1806-2022
OI Luevano-Contreras, Claudia/0000-0002-2632-8093; Rodriguez Mortera,
   Reyna/0000-0003-4679-1955
FU Grant DAIP University of Guanajuato [011/2015]; Touro
   University-California [069]
FX Grant DAIP University of Guanajuato (Project 011/2015) and Touro
   University-California (069).
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NR 47
TC 11
Z9 11
U1 1
U2 11
PU WALTER DE GRUYTER GMBH
PI BERLIN
PA GENTHINER STRASSE 13, D-10785 BERLIN, GERMANY
SN 1434-6621
EI 1437-4331
J9 CLIN CHEM LAB MED
JI Clin. Chem. Lab. Med.
PD JUL
PY 2018
VL 56
IS 7
BP 1100
EP 1108
DI 10.1515/cclm-2017-0733
PG 9
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA GH8GM
UT WOS:000433906000019
PM 29447114
DA 2025-06-11
ER

PT J
AU Altamura, S
   Müdder, K
   Schlotterer, A
   Fleming, T
   Heidenreich, E
   Qiu, RY
   Hammes, HP
   Nawroth, P
   Muckenthaler, MU
AF Altamura, Sandro
   Muedder, Katja
   Schlotterer, Andrea
   Fleming, Thomas
   Heidenreich, Elena
   Qiu, Ruiyue
   Hammes, Hans-Peter
   Nawroth, Peter
   Muckenthaler, Martina U.
TI Iron aggravates hepatic insulin resistance in the absence of
   inflammation in a novel db/db mouse model with iron overload
SO MOLECULAR METABOLISM
LA English
DT Article
DE NAFLD; Insulin resistance; Iron; Hepcidin
ID FATTY LIVER-DISEASE; NONALCOHOLIC STEATOHEPATITIS; HEREDITARY
   HEMOCHROMATOSIS; METABOLIC SYNDROME; HEPCIDIN; FERROPORTIN; EXPRESSION;
   RISK; HYPERGLYCEMIA; ADIPONECTIN
AB Objective: The molecular pathogenesis of late complications associated with type 2 diabetes mellitus (T2DM) is not yet fully understood. While high glucose levels indicated by increased HbA1c only poorly explain disease progression and late complications, a pro-inflammatory status, oxidative stress, and reactive metabolites generated by metabolic processes were postulated to be involved. Individuals with metabolic syndrome (MetS) frequently progress to T2DM, whereby 70% of patients with T2DM show non-alcoholic fatty liver disease (NAFLD), the hepatic manifestation of MetS, and insulin resistance (IR). Epidemiological studies have shown that T2DM and steatosis are associated with alterations in iron metabolism and hepatic iron accumulation. Excess free iron triggers oxidative stress and a switch towards a macrophage pro-inflammatory status. However, so far it remains unclear whether hepatic iron accumulation plays a causative role in the generation of IR and T2DM or whether it is merely a manifestation of altered hepatic metabolism. To address this open question, we generated and characterized a mouse model of T2DM with IR, steatosis, and iron overload. Methods: Leprdb/db mice hallmarked by T2DM, IR and steatosis were crossed with Fpnwt/C326S mice with systemic iron overload to generate Leprdb/db/Fpnwt/C326S mice. The resulting progeny was characterized for major diabetic and iron-related parameters. Results: We demonstrated that features associated with T2DM in Leprdb/db mice, such as obesity, steatosis, or IR, reduce the degree of tissue iron overload in Fpnwt/C326S mice, suggesting an 'iron resistance' phenotype. Conversely, we observed increased serum iron levels that strongly exceeded those in the iron-overloaded Fpnwt/C326S mice. Increased hepatic iron levels induced oxidative stress and lipid peroxidation and aggravated IR, as indicated by diminished IRS1 phosphorylation and AKT activation. Additionally, in the liver, we observed gene response patterns indicative of de novo lipogenesis and increased gluconeogenesis as well as elevated free glucose levels. Finally, we showed that iron overload in Leprdb/db/Fpnwt/C326S mice enhances microvascular complications observed in retinopathy, suggesting that iron accumulation can enhance diabetic late complications associated with the liver and the eye. Conclusion: Taken together, our data show that iron causes the worsening of symptoms associated with the MetS and T2DM. These findings imply that iron depletion strategies together with anti-diabetic drugs may ameliorate IR and diabetic late complications. (c) 2021 The Author(s). Published by Elsevier GmbH. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
C1 [Altamura, Sandro; Muedder, Katja; Qiu, Ruiyue; Muckenthaler, Martina U.] Heidelberg Univ, Dept Pediat Hematol Oncol & Immunol, Heidelberg, Germany.
   [Altamura, Sandro; Muckenthaler, Martina U.] Mol Med Partnership Unit, Heidelberg, Germany.
   [Schlotterer, Andrea; Hammes, Hans-Peter] Heidelberg Univ, Med Fac Mannheim, Dept Med 5, Heidelberg, Germany.
   [Schlotterer, Andrea; Hammes, Hans-Peter] Heidelberg Univ, European Ctr Angiosci ECAS, Ctr Diabet Res DZD, Fac Med, Heidelberg, Germany.
   [Fleming, Thomas; Nawroth, Peter] Heidelberg Univ, Dept Internal Med & Clin Chem, Heidelberg, Germany.
   [Fleming, Thomas; Nawroth, Peter] German Ctr Diabet Res DZD, Neuherberg, Germany.
   [Heidenreich, Elena] Heidelberg Univ, Ctr Organismal Studies COS, Heidelberg, Germany.
   [Nawroth, Peter] Helmholtz Zentrum Munich, Inst Diabet & Canc, Neuherberg, Germany.
C3 Ruprecht Karls University Heidelberg; Ruprecht Karls University
   Heidelberg; Ruprecht Karls University Heidelberg; Ruprecht Karls
   University Heidelberg; German Center for Diabetes Research (DZD);
   Ruprecht Karls University Heidelberg; Helmholtz Association;
   Helmholtz-Center Munich - German Research Center for Environmental
   Health
RP Muckenthaler, MU (corresponding author), Heidelberg Univ, Dept Pediat Hematol Oncol & Immunol, Heidelberg, Germany.; Muckenthaler, MU (corresponding author), Mol Med Partnership Unit, Heidelberg, Germany.
EM martina.muckenthaler@med.uni-heidelberg.de
RI Schlotterer, Andrea/GWC-7442-2022; Hammes, Hans-Peter/S-3719-2019;
   Altamura, Sandro/ISV-0741-2023
OI Muckenthaler, Martina/0000-0002-3778-510X; Qiu,
   Ruiyue/0000-0002-4036-6192; Altamura, Sandro/0000-0002-6781-1073;
   Schlotterer, Andrea/0000-0002-9572-8146
FU German Research Foundation [DFG - SFB1118]
FX This study was supported by the German Research Foundation [DFG -
   SFB1118].
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NR 61
TC 61
Z9 65
U1 0
U2 12
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2212-8778
J9 MOL METAB
JI Mol. Metab.
PD SEP
PY 2021
VL 51
AR 101235
DI 10.1016/j.molmet.2021.101235
EA MAY 2021
PG 13
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA UD0HK
UT WOS:000686898200001
PM 33872860
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Kawamoto, R
   Tabara, Y
   Kohara, K
   Miki, T
   Kusunoki, T
   Takayama, S
   Abe, M
   Katoh, T
   Ohtsuka, N
AF Kawamoto, Ryuichi
   Tabara, Yasuharu
   Kohara, Katsuhiko
   Miki, Tetsuro
   Kusunoki, Tomo
   Takayama, Shuzo
   Abe, Masanori
   Katoh, Tateaki
   Ohtsuka, Nobuyuki
TI High-sensitivity c-reactive protein and gamma-glutamyl transferase
   levels are synergistically associated with metabolic syndrome in
   community-dwelling persons
SO CARDIOVASCULAR DIABETOLOGY
LA English
DT Article
ID CARDIOVASCULAR-DISEASE MORTALITY; INSULIN-RESISTANCE; ADIPOSE-TISSUE;
   RISK; POPULATION; HEALTH; ATHEROSCLEROSIS; DEFINITION; PREVALENCE;
   GLUCOSE
AB Background: Metabolic syndrome (MetS) is associated with an increased risk of major cardiovascular events. Increased high-sensitivity C-reactive protein (hsCRP) levels are associated with MetS and its components. Changes in gamma-glutamyl transferase (GGT) levels in response to oxidative stress are also associated with MetS, and the levels could be modulated by hsCRP.
   Methods: From a single community, we recruited 822 men (mean age, 61 +/- 14 years) and 1,097 women (63 +/- 12 years) during their annual health examination. We investigated whether increased hsCRP and GGT levels are synergistically associated with MetS and insulin resistance evaluated by Homeostasis of model assessment of insulin resistance (HOMA-IR).
   Results: Of these subjects, 141 men (17.2%) and 170 women (15.5%) had MetS. Participants with MetS had a higher hsCRP and GGT level than those without MetS in both genders, and the HOMA-IR increased significantly in correlation with an increase in hsCRP and GGT. In men, the adjusted odds ratios (95% confidence interval) for MetS across tertiles of hsCRP and GGT were 1.00, 1.69 (1.01-2.80), and 2.13 (1.29-3.52), and 1.00, 3.26 (1.84-5.78) and 6.11 (3.30-11.3), respectively. In women, the respective corresponding values were 1.00, 1.54 (0.92-2.60), and 3.08 (1.885.06), and 1.00, 1.70 (1.04-2.79) and 2.67 (1.66-4.30). The interaction between increased hsCRP and GGT was a significant and independent determinant for MetS and insulin resistance in both genders.
   Conclusions: These results suggested that higher CRP and GGT levels were synergistically associated with MetS and insulin resistance, independently of other confounding factor in the general population.
C1 [Kawamoto, Ryuichi; Kusunoki, Tomo; Takayama, Shuzo; Abe, Masanori] Ehime Univ Grad Sch Med, Dept Community Med, Matsuyama, Ehime 7910295, Japan.
   [Kawamoto, Ryuichi; Kusunoki, Tomo; Katoh, Tateaki; Ohtsuka, Nobuyuki] Seiyo Municipal Nomura Hosp, Dept Internal Med, Seiyo, Ehime 7971212, Japan.
RP Kawamoto, R (corresponding author), Ehime Univ Grad Sch Med, Dept Community Med, Matsuyama, Ehime 7910295, Japan.
EM rykawamo@yahoo.co.jp
FU Foundation for Development of Community
FX This work was supported in part by a grant-in-aid for Scientific
   Research from the Foundation for Development of Community (2009).
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NR 43
TC 39
Z9 45
U1 0
U2 2
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1475-2840
J9 CARDIOVASC DIABETOL
JI Cardiovasc. Diabetol.
PD DEC 9
PY 2010
VL 9
AR 87
DI 10.1186/1475-2840-9-87
PG 10
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism
GA 702GT
UT WOS:000285883300001
PM 21143879
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Darenskaya, MA
   Belenkaia, L
   Suturina, L
   Kolesnikov, SI
   Sholokhov, LF
   Lazareva, LM
   Nadelyaeva, YG
   Danusevich, IN
   Kolesnikova, LI
AF Darenskaya, Marina A.
   Belenkaia, Lilia, V
   Suturina, Larisa, V
   Kolesnikov, Sergey I.
   Sholokhov, Leonid F.
   Lazareva, Lydmila M.
   Nadelyaeva, Yana G.
   Danusevich, Irina N.
   Kolesnikova, Lyubov I.
TI Metabolic Syndrome in Caucasian Women with Hyperandrogenism: Lipid
   Metabolism and Lipid Peroxidation System
SO INTERNATIONAL JOURNAL OF BIOMEDICINE
LA English
DT Article
DE metabolic syndrome; hyperandrogenism; lipids; lipid peroxidation;
   antioxidant defense
ID POLYCYSTIC-OVARY-SYNDROME; OXIDATIVE STRESS; ANTIOXIDANT STATUS;
   ADOLESCENTS; RISK; HORMONE; OBESITY; INSULIN
AB Background: The study aimed to evaluate the parameters of lipid metabolism and lipid peroxidation (LPO) - antioxidant defense (AOD) system disorders in Caucasian women with metabolic syndrome (MetS) and hyperandrogenism (HA). Methods and Results: 300 Caucasian women of reproductive age (18-44 years) living in the Irkutsk region and the Republic of Buryatia territories were examined. According to MetS and polycystic ovary syndrome (PCOS) diagnostic criteria, the following groups were formed: Group 1 included 209 women with MetS, and Group 2 included 23 women with MetS and PCOS (hyperandrogenic phenotypes). The control group (n=68) consisted of practically healthy women. The parameters of lipid metabolism (triglycerides [TG], low-density lipoprotein cholesterol [LDL-C], high-density lipoprotein cholesterol [HDL-C]), lipid peroxidation system (double bounds [DBs], conjugated dienes [CDs], ketodienes and conjugated trienes [KD and CT], thiobarbituric acids reactive substances [TBARS]), and antioxidant defense (total antioxidant activity [TAA], superoxide dismutase [SOD] activity, reduced glutathione [GSH], oxidized glutathione [GSSG], retinol, alpha-tocopherol) were studied. Spectrophotometric, fluorometric, and statistic methods were used. In Group 1 (MetS), the levels of TG and LDL-C were significantly higher than in the control group (P<0.0001 and P=0.046, respectively). In contrast, the HDL-C level was significantly lower than in the control group (P<0001). Similarly, in Group 2 (MetS+HA), we found an increase in the TG level (P<0.001) and a decrease in the HDL-C level (P=0.008) compared with the control group. (Table 1). There were no differences between Groups 1 and 2 (P>0.05). The LPO reactions were more intense in women with MetS, characterized by a higher content of substrates with DBs (P=0.010) and TBARS (P=0.037) compared with the control group. In Group 2 (MetS+HA), only the TBARS level was statistically significantly higher (P=0.008) than in the control group. In Group 1 (MetS), the SOD activity and the levels of alpha-tocopherol and retinol were significantly higher than in the control group (P=0.005, P=0.017, and P<0.001, respectively) (Table 3). The SOD activity was significantly lower in Group 2 (MetS+HA) than in Group 1 (MetS) (P=0.043). The remaining indicators of antioxidant defense status did not differ significantly between Groups 1 and 2. Conclusion: The data obtained indicated a proatherogenic nature of lipid metabolism, increased LPO reactions, and a compensatory increase in some components of the AOD system in Caucasian women with MetS. In women with the MetS-HA comorbidity, the activity of AOD factors does not increase.
C1 [Darenskaya, Marina A.; Belenkaia, Lilia, V; Suturina, Larisa, V; Kolesnikov, Sergey I.; Sholokhov, Leonid F.; Lazareva, Lydmila M.; Nadelyaeva, Yana G.; Danusevich, Irina N.; Kolesnikova, Lyubov I.] Sci Ctr Family Hlth & Human Reprod Problems, Irkutsk, Russia.
C3 Irkutsk Science Centre of the Russian Academy of Sciences; Scientific
   Centre for Family Health & Human Reproduction Problems
RP Darenskaya, MA (corresponding author), Sci Ctr Family Hlth & Human Reprod Problems, Irkutsk, Russia.
EM marina_darenskaya@inbox.ru
RI Darenskaya, Marina/O-4490-2015; Kolesnikova, Lubov/H-6424-2013;
   Kolesnikov, Sergey/M-4020-2016
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NR 40
TC 0
Z9 0
U1 1
U2 1
PU INT MEDICAL RESEARCH & DEVELOPMENT CORP
PI NEW YORK
PA 6308 12TH AVE, NEW YORK, NY 11219 USA
SN 2158-0510
EI 2158-0529
J9 INT J BIOMED
JI Int. J. Biomed.
PD MAR
PY 2025
VL 15
IS 1
BP 84
EP 89
DI 10.21103/Article15(1)_OA5
PG 6
WC Medicine, Research & Experimental
WE Emerging Sources Citation Index (ESCI)
SC Research & Experimental Medicine
GA 1CH5D
UT WOS:001461619500013
OA gold
DA 2025-06-11
ER

PT J
AU Muthuramalingam, K
   Singh, V
   Choi, C
   Choi, SI
   Kim, YM
   Unno, T
   Cho, M
AF Muthuramalingam, Karthika
   Singh, Vineet
   Choi, Changmin
   Choi, Seung In
   Kim, Young Mee
   Unno, Tatsuya
   Cho, Moonjae
TI Dietary intervention using (1,3)/(1,6)-β-glucan, a fungus-derived
   soluble prebiotic ameliorates high-fat diet-induced metabolic distress
   and alters beneficially the gut microbiota in mice model
SO EUROPEAN JOURNAL OF NUTRITION
LA English
DT Article
DE High-fat diet; Gut microbiota; beta-glucan; Prebiotics; Obesity;
   Metabolic syndrome
ID RNA GENE DATABASE; INDUCED OBESITY; MOUSE MODEL; SENSITIVITY; DYSBIOSIS;
   BACTERIA; TRANSIT; IMPACT
AB Purpose Western diet, rich in carbohydrates and fat, is said to be a major factor underlying metabolic syndrome. Interventions with prebiotics, the key modulators of the gut microbiota, have paramount impact on host-associated metabolic disorders. Herein, we investigated the effect of fungus-derived (1,3)/(1,6)-beta-glucan, a highly soluble dietary fiber, on high-fat diet (HFD)-induced metabolic distress. Methods Male C57BL/6 J mice were fed with different diet groups (n = 11): control diet, HFD, 3 g/kg or 5 g/kg of beta-glucan-incorporated HFD. At the end of experimental study period (12th week), body weight, feces weight and fecal moisture content were observed. Further, colonic motility was measured using activated charcoal meal study. Proteins extracted from liver and intestine tissues were subjected to western blot technique. Paraffin-embedded intestinal tissues were sectioned for histochemical [Periodic acid-Schiff (PAS) and Alcian blue (AB) staining] analysis. Fecal microbiota analysis was performed using MOTHUR bioinformatic software. Results beta-glucan consumption exhibited anti-obesity property in mice groups fed with HFD. In addition, beta-glucan ameliorated HFD-induced hepatic stress, colonic motility and intestinal atrophy (reduction in colon length, goblet cells, and mucosal layer thickness). Further, beta-glucan incorporation shifted bacterial community by increasing butyrate-producing bacteria such as Anaerostipes, Coprobacillus, and Roseburia and decreasing reportedly obesity-associated bacteria such as Parabacteroides and Lactococcus. Conclusion Altogether, the outcomes of this present pre-clinical animal study show beta-glucan to be a promising therapeutic candidate in the treatment of HFD-induced metabolic distress. Further comprehensive research has to be conducted to brace its clinical relevance, reproducibility and efficacy for aiding human health.
   [GRAPHICS]
   .
C1 [Muthuramalingam, Karthika; Choi, Changmin; Kim, Young Mee; Cho, Moonjae] Jeju Natl Univ, Sch Med, Dept Biochem, Jeju 63243, South Korea.
   [Singh, Vineet; Unno, Tatsuya] Jeju Natl Univ, Fac Biotechnol, Sch Life Sci, SARI, Jeju 63243, South Korea.
   [Choi, Seung In] Quegen Biotech Co Ltd, Dept Pharmaceut Res Inst, Seoul 429931, South Korea.
   [Unno, Tatsuya] Jeju Natl Univ, Subtrop Trop Organism Gene Bank, Jeju 63243, South Korea.
   [Cho, Moonjae] Jeju Natl Univ, Inst Med Sci, Jeju 63241, South Korea.
   [Cho, Moonjae] Jeju Natl Univ, Interdisciplinary Grad Program Adv Convergence Te, Jeju 63241, South Korea.
C3 Jeju National University; Jeju National University; Jeju National
   University; Jeju National University; Jeju National University
RP Cho, M (corresponding author), Jeju Natl Univ, Sch Med, Dept Biochem, Jeju 63243, South Korea.; Unno, T (corresponding author), Jeju Natl Univ, Fac Biotechnol, Sch Life Sci, SARI, Jeju 63243, South Korea.; Unno, T (corresponding author), Jeju Natl Univ, Subtrop Trop Organism Gene Bank, Jeju 63243, South Korea.; Cho, M (corresponding author), Jeju Natl Univ, Inst Med Sci, Jeju 63241, South Korea.; Cho, M (corresponding author), Jeju Natl Univ, Interdisciplinary Grad Program Adv Convergence Te, Jeju 63241, South Korea.
EM tatsu@jejunu.ac.kr; moonjcho@jejunu.ac.kr
RI Unno, Tatsuya/C-1522-2012; Singh, Vineet/ABC-7000-2021
OI Unno, Tatsuya/0000-0003-2373-2100; Singh, Vineet/0000-0003-2458-3282
FU "Cooperative Research Program for Agriculture Science and Technology
   Development" Rural Development Administration, Republic of Korea
   [PJ01331801]; Basic Science Research Program through the National
   Research Foundation of Korea (NRF) - Ministry of Education
   [2016R1A6A1A03012862]
FX This work was carried out with the support of the "Cooperative Research
   Program for Agriculture Science and Technology Development (Project No.
   PJ01331801)" Rural Development Administration, Republic of Korea. This
   research was also supported, in part, by the Basic Science Research
   Program through the National Research Foundation of Korea (NRF) funded
   by the Ministry of Education (2016R1A6A1A03012862).
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NR 51
TC 36
Z9 38
U1 3
U2 35
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1436-6207
EI 1436-6215
J9 EUR J NUTR
JI Eur. J. Nutr.
PD SEP
PY 2020
VL 59
IS 6
BP 2617
EP 2629
DI 10.1007/s00394-019-02110-5
EA OCT 2019
PG 13
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA MW4ND
UT WOS:000493262000001
PM 31664519
DA 2025-06-11
ER

PT J
AU Michishita, R
   Matsuda, T
   Kawakami, S
   Tanaka, S
   Kiyonaga, A
   Tanaka, H
   Morito, N
   Higaki, Y
AF Michishita, Ryoma
   Matsuda, Takuro
   Kawakami, Shotaro
   Tanaka, Satoshi
   Kiyonaga, Akira
   Tanaka, Hiroaki
   Morito, Natsumi
   Higaki, Yasuki
TI Hypertension and hyperglycemia and the combination thereof enhances the
   incidence of chronic kidney disease (CKD) in middle-aged and older males
SO CLINICAL AND EXPERIMENTAL HYPERTENSION
LA English
DT Article
DE Cardiovascular risk factors; diabetes mellitus; high-normal blood
   pressure; hypertension; impaired fasting glucose; incidence of CKD
ID ISCHEMIC-HEART-DISEASE; LIFE-STYLE BEHAVIORS; BLOOD-PRESSURE;
   CARDIOVASCULAR-DISEASES; METABOLIC SYNDROME; GLUCOSE-TOLERANCE;
   OXIDATIVE STRESS; RISK-FACTORS; BASE-LINE; FOLLOW-UP
AB Aim: Chronic kidney disease (CKD) may be an etiologic cause of aging, hypertension, diabetes mellitus (DM), and metabolic syndrome. However, the influence of these cardiovascular risk factors and their combination on the development of CKD remains controversial. This retrospective study evaluated the influence of cardiovascular risk factors and their combination on the incidence of CKD during a 6-year follow-up period in middle-aged and older males. Methods: The subjects were 303 males without a history of cardiovascular disease, stroke, renal dysfunction, or dialysis treatment. A biochemical analysis, blood pressure (BP) analysis, and anthropometry measurements were performed every year, and the classification of CKD was also assessed based on the estimated glomerular filtration rate (<60 ml/min/1.73 m(2)) and/or presence of proteinuria. Results: After 6 years, the incidence of CKD was noted in 32 subjects. According to a multivariable analysis, hypertension (hazard ratio [HR]: 3.95, 95% confidence of interval [CI]: 1.64-9.49, p = 0.002) and hyperglycemia (HR: 3.27, 95% CI: 1.42-7.56, p = 0.006) were significantly associated with the incidence of CKD. According to a Cox proportional hazards model, the HR for the incidence of CKD was significantly higher in the combination of high-normal BP/hypertension and impaired fasting glucose/DM group than in the combination of normotensive and normal glucose tolerance group (HR: 7.16, 95% CI: 2.43-17.25, p = 0.001). Conclusions: These results suggest that the hypertension and hyperglycemia and their combination may be associated with the incidence of CKD.
C1 [Michishita, Ryoma] Univ Occupat & Environm Hlth, Inst Ind Ecol Sci, Dept Hlth Dev, Kitakyushu, Fukuoka, Japan.
   [Michishita, Ryoma; Matsuda, Takuro; Kiyonaga, Akira; Tanaka, Hiroaki; Higaki, Yasuki] Fukuoka Univ, Inst Phys Act, Fukuoka, Japan.
   [Matsuda, Takuro] Fukuoka Univ Hosp, Dept Phys Med & Rehabil, Fukuoka, Japan.
   [Kawakami, Shotaro; Tanaka, Satoshi; Tanaka, Hiroaki; Higaki, Yasuki] Fukuoka Univ, Fac Hlth & Sports Sci, Lab Exercise Physiol, Fukuoka, Japan.
   [Morito, Natsumi] Fukuoka Univ, Hlth Care Ctr, Fukuoka, Japan.
   [Morito, Natsumi] Fukuoka Univ, Sch Med, Dept Cardiol, Fukuoka, Japan.
C3 University of Occupational & Environmental Health - Japan; Fukuoka
   University; Fukuoka University; Fukuoka University; Fukuoka University;
   Fukuoka University
RP Michishita, R (corresponding author), Univ Occupat & Environm Hlth, Inst Ind Ecol Sci, Dept Hlth Dev, Yahatanishi Ku, 1-1 Iseigaoka, Kitakyushu, Fukuoka 8078555, Japan.
EM rmichishita@med.uoeh-u.ac.jp
RI Kawakami, Shotaro/HSG-0371-2023
OI Kawakami, Shotaro/0000-0002-1334-1918
FU Ministry of Education, Science, Sports and Culture of Japan [15H03082];
   Fukuoka University Institute for Physical Activity; Grants-in-Aid for
   Scientific Research [15H03082, 25242065] Funding Source: KAKEN
FX This work was performed with the supports of Grants-in-Aid from the
   Ministry of Education, Science, Sports and Culture of Japan (No.
   15H03082) and the Fukuoka University Institute for Physical Activity.
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NR 41
TC 19
Z9 22
U1 0
U2 3
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1064-1963
EI 1525-6006
J9 CLIN EXP HYPERTENS
JI Clin. Exp. Hypertens.
PY 2017
VL 39
IS 7
BP 645
EP 654
DI 10.1080/10641963.2017.1306541
PG 10
WC Pharmacology & Pharmacy; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Cardiovascular System & Cardiology
GA FK7SY
UT WOS:000413708700009
PM 28590145
DA 2025-06-11
ER

PT J
AU Limberg, JK
   Kellawan, JM
   Harrell, JW
   Johansson, RE
   Eldridge, MW
   Proctor, LT
   Sebranek, JJ
   Schrage, WG
AF Limberg, Jacqueline K.
   Kellawan, J. Mikhail
   Harrell, John W.
   Johansson, Rebecca E.
   Eldridge, Marlowe W.
   Proctor, Lester T.
   Sebranek, Joshua J.
   Schrage, William G.
TI Exercise-mediated vasodilation in human obesity and metabolic syndrome:
   effect of acute ascorbic acid infusion
SO AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
LA English
DT Article
DE blood flow; reactive oxygen species; antioxidant
ID BLOOD-FLOW DISTRIBUTION; SKELETAL-MUSCLE; OXIDATIVE STRESS; FOREARM
   EXERCISE; NITRIC-OXIDE; ZUCKER RATS; PRESSURE RESPONSE; DYNAMIC
   EXERCISE; AGING HUMANS; HYPEREMIA
AB We tested the hypothesis that infusion of ascorbic acid (AA), a potent antioxidant, would alter vasodilator responses to exercise in human obesity and metabolic syndrome (MetSyn). Forearm blood flow (FBF, Doppler ultrasound) was measured in lean, obese, and MetSyn adults (n = 39, 32 +/- 2 yr). A brachial artery catheter was inserted for blood pressure monitoring and local infusion of AA. FBF was measured during dynamic handgrip exercise (15% maximal effort) with and without AA infusion. To account for group differences in blood pressure and forearm size, and to assess vasodilation, forearm vascular conductance (FVC = FBF/mean arterial blood pressure/lean forearm mass) was calculated. We examined the time to achieve steady-state FVC (mean response time, MRT) and the rise in FVC from rest to steady-state exercise (Delta, exercise - rest) before and during acute AA infusion. The MRT (P = 0.26) and steady-state vasodilator responses to exercise (Delta FVC, P = 0.31) were not different between groups. Intra-arterial infusion of AA resulted in a significant increase in plasma total antioxidant capacity (174 +/- 37%). AA infusion did not alter MRT or steady-state FVC in any group (P = 0.90 and P = 0.85, respectively). Interestingly, higher levels of C-reactive protein predicted longer MRT (r = 0.52, P < 0.01) and a greater reduction in MRT with AA infusion (r = -0.43, P = 0.02). We concluded that AA infusion during moderate-intensity, rhythmic forearm exercise does not alter the time course or magnitude of exercise-mediated vasodilation in groups of young lean, obese, or MetSyn adults. However, systemic inflammation may limit the MRT to exercise, which can be improved with AA.
C1 [Limberg, Jacqueline K.; Kellawan, J. Mikhail; Harrell, John W.; Johansson, Rebecca E.; Schrage, William G.] Univ Wisconsin, Sch Educ, Dept Kinesiol, Madison, WI USA.
   [Eldridge, Marlowe W.] Univ Wisconsin, Hosp & Clin, Sch Med & Publ Hlth, Dept Pediat, Madison, WI 53792 USA.
   [Proctor, Lester T.; Sebranek, Joshua J.] Univ Wisconsin, Hosp & Clin, Sch Med & Publ Hlth, Dept Anesthesiol, Madison, WI 53792 USA.
C3 University of Wisconsin System; University of Wisconsin Madison;
   University of Wisconsin System; University of Wisconsin Madison;
   University of Wisconsin System; University of Wisconsin Madison
RP Schrage, WG (corresponding author), 2000 Observ Dr,Rm 1149A, Madison, WI 53706 USA.
EM wschrage@education.wisc.edu
RI Kellawan, Jeremy/J-3599-2019
OI Kellawan, Jeremy Mikhail/0000-0001-7889-8146; Johansson,
   Rebecca/0000-0002-0605-1293
FU American Heart Association predoctoral awards [10PRE3870000,
   11PRE7390038]; National Institutes of Health (NIH) [HL091397, HL105820,
   RR000167]; NIH National Center for Advancing Translational Sciences
   [UL1TR000427]; American Heart Association (AHA) [10PRE3870000,
   11PRE7390038] Funding Source: American Heart Association (AHA)
FX This study was supported by the American Heart Association predoctoral
   awards 10PRE3870000 (J. Limberg) and 11PRE7390038 (J. Harrell), and the
   National Institutes of Health (NIH) HL091397 (W. Schrage) and HL105820
   (W. Schrage). In addition, we acknowledge the involvement of WNPRC Assay
   Services and the partial support of NIH grant RR000167. This study was
   also supported by the Clinical and Translational Science Award program
   through the NIH National Center for Advancing Translational Sciences
   Grant UL1TR000427. The content is solely the responsibility of the
   authors and does not necessarily represent the official views of the
   NIH.
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NR 38
TC 11
Z9 11
U1 0
U2 9
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0363-6135
EI 1522-1539
J9 AM J PHYSIOL-HEART C
JI Am. J. Physiol.-Heart Circul. Physiol.
PD SEP 15
PY 2014
VL 307
IS 6
BP H840
EP H847
DI 10.1152/ajpheart.00312.2014
PG 8
WC Cardiac & Cardiovascular Systems; Physiology; Peripheral Vascular
   Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Physiology
GA AO9SQ
UT WOS:000341697500004
PM 25038148
OA Green Published
DA 2025-06-11
ER

PT J
AU Tian, YF
   He, CT
   Chen, YT
   Hsieh, PS
AF Tian, Yu-Feng
   He, Chih-Tsueng
   Chen, Yu-Ting
   Hsieh, Po-Shiuan
TI Lipoic acid suppresses portal endotoxemia-induced steatohepatitis and
   pancreatic inflammation in rats
SO WORLD JOURNAL OF GASTROENTEROLOGY
LA English
DT Article
DE Lipoic acid; Oxidative stress; Steatohepatitis; Portal endotoxemia;
   Insulin secretion; Fructose
ID NONALCOHOLIC STEATOHEPATITIS; RECEPTOR 4; INSULIN-RESISTANCE; METABOLIC
   SYNDROME; LIVER-DISEASE; ALPHA; MICE; INTERLEUKIN-6; PATHOGENESIS;
   ANTIOXIDANT
AB AIM: To examine the effect of alpha-lipoic acid (LA) on mild portal endotoxemia-induced steatohepatitis and associated pancreatic abnormalities in fructose-fed rats.
   METHODS: Rats were randomly assigned into two groups with a regular or 60% fructose-enriched diet for 8 wk. After fructose feeding for 4 wk, rats were further divided into four subgroups: with intraportal saline (FPV), with intraportal saline plus administration of LA (FPV + LA), with lipopolysaccharide (LPS) infusion (FPLPS), and with LPS infusion plus administration of LA (FPLPS + LA). Rats were treated with LPS using intraportal infusion while LA was administered orally. Metabolite levels, superoxide levels, inflammatory markers, malondialdehyde content, glutathione content and toll-like receptor 4 (TLR4) gene expression were all measured using standard biochemical techniques. Pancreatic insulin secretion was evaluated by a hyperglycemic clamp technique. Histology of liver and pancreas tissues were evaluated using hematoxylin and eosin staining and immunohistochemistry.
   RESULTS: Fructose-induced elevation in plasma C-reactive protein, amylase, superoxide, white blood cell count as well as in hepatic and pancreatic contents of malondialdehyde, tumor necrosis factor alpha and interleukin-6 were increased in animals treated with LPS and reversed with LA administration. The augmented hepatic gene expression of TLR4 in fructose-fed rats was further increased in those with intraportal LPS infusion, which was partially reversed by LA administration. Pathological examination showed inflammatory changes and leukocyte infiltration in hepatic and pancreatic islets of animals treated with LPS but were rarely observed in those with LA treatment. In addition to affects on the liver, impaired pancreatic insulin secretion seen in fructose-fed rats was deteriorated in with LPS treatment and partially reversed with LA administration.
   CONCLUSION: These data suggest LA could significantly suppress mild portal-endotoxemia but not fructose-induced liver and pancreatic abnormalities in a rodent model for metabolic syndrome. (C) 2013 Baishideng. All rights reserved.
C1 [Tian, Yu-Feng] Chi Mei Med Ctr, Dept Surg, Div Gen Surg, Tainan 710, Taiwan.
   [Tian, Yu-Feng] Chia Nan Univ Pharm & Sci, Dept Hlth & Nutr, Tainan 717, Taiwan.
   [He, Chih-Tsueng] Tri Serv Gen Hosp, Dept Internal Med, Div Endocrinol & Metab, Taipei 114, Taiwan.
   [Chen, Yu-Ting; Hsieh, Po-Shiuan] Natl Def Med Ctr, Dept Physiol & Biophys, Taipei 114, Taiwan.
   [Hsieh, Po-Shiuan] Tri Serv Gen Hosp, Dept Med Res, Taipei 114, Taiwan.
C3 Chi Mei Hospital; Chia Nan University of Pharmacy & Science; Tri-Service
   General Hospital; National Defense Medical Center; Tri-Service General
   Hospital
RP Hsieh, PS (corresponding author), Natl Def Med Ctr, Dept Physiol & Biophys, 161,Sect 6 Min Chuan East Rd, Taipei 114, Taiwan.
EM pshsieh@hotmail.com
RI Hsieh, Po-Shiuan/AAF-4173-2020
OI He, Chih-Tsueng/0000-0002-1918-5186
FU National Science Council of the ROC [NSC98-2320-B-011 MY3, CMNDMC
   100-05, TSGH-C100-011-015-S03]
FX Supported by Grants from the National Science Council of the ROC, No.
   NSC98-2320-B-011 MY3, CMNDMC 100-05 and TSGH-C100-011-015-S03
CR Abdin AA, 2010, EUR J PHARMACOL, V643, P289, DOI 10.1016/j.ejphar.2010.06.020
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NR 34
TC 24
Z9 28
U1 0
U2 11
PU BAISHIDENG PUBL GRP CO LTD
PI WANCHAI
PA ROOM 1701, 17-F, HENAN BUILDING, NO. 90, JAFFE RD, WANCHAI, HONG KONG
   100025, PEOPLES R CHINA
SN 1007-9327
J9 WORLD J GASTROENTERO
JI World J. Gastroenterol.
PD MAY 14
PY 2013
VL 19
IS 18
BP 2761
EP 2771
DI 10.3748/wjg.v19.i18.2761
PG 11
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 143XP
UT WOS:000318902800005
PM 23687413
OA Green Submitted, hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Sottile, F
   Napolitano, A
   Badalamenti, N
   Bruno, M
   Tundis, R
   Loizzo, MR
   Piacente, S
AF Sottile, Francesco
   Napolitano, Assunta
   Badalamenti, Natale
   Bruno, Maurizio
   Tundis, Rosa
   Loizzo, Monica Rosa
   Piacente, Sonia
TI A New Bloody Pulp Selection of Myrobalan (Prunus cerasifera L.):
   Pomological Traits, Chemical Composition, and Nutraceutical Properties
SO FOODS
LA English
DT Article
DE Prunus cerasifera; myrobalan; LC-MS analysis; antioxidant activity;
   lipase and carbohydrate hydrolyzing enzymes inhibitory effects
ID ANTIOXIDANT CAPACITY; DOMESTICA L.; LIQUID-CHROMATOGRAPHY;
   MASS-SPECTROMETRY; ANTIDIABETIC ACTIVITY; METABOLIC SYNDROME;
   PHENOLIC-COMPOUNDS; OXIDATIVE STRESS; ALPHA-AMYLASE; CHERRY
AB A new accession of myrobalan (Prunus cerasifera L.) from Sicily (Italy) was studied for the first time for its chemical and nutraceutical properties. A description of the main morphological and pomological traits was created as a tool for characterization for consumers. For this purpose, three different extracts of fresh myrobalan fruits were subjected to different analyses, including the evaluation of total phenol (TPC), flavonoid (TFC), and anthocyanin (TAC) contents. The extracts exhibited a TPC in the range 34.52-97.63 mg gallic acid equivalent (GAE)/100 g fresh weight (FW), a TFC of 0.23-0.96 mg quercetin equivalent (QE)/100 g FW, and a TAC of 20.24-55.33 cyanidine-3-O-glucoside/100 g FW. LC-HRMS analysis evidenced that the compounds mainly belong to the flavonols, flavan-3-ols, proanthocyanidins, anthocyanins, hydroxycinnamic acid derivatives, and organic acids classes. A multitarget approach was used to assess the antioxidant properties by using FRAP, ABTS, DPPH, and beta-carotene bleaching tests. Moreover, the myrobalan fruit extracts were tested as inhibitors of the key enzymes related to obesity and metabolic syndrome (alpha-glucosidase, alpha-amylase, and lipase). All extracts exhibited an ABTS radical scavenging activity that was higher than the positive control BHT (IC50 value in the range 1.19-2.97 mu g/mL). Moreover, all extracts showed iron-reducing activity, with a potency similar to that of BHT (53.01-64.90 vs 3.26 mu M Fe(II)/g). The PF extract exhibited a promising lipase inhibitory effect (IC50 value of 29.61 mu g/mL).
C1 [Sottile, Francesco] Univ Palermo, Dept Architecture, Viale Sci, I-90128 Palermo, PA, Italy.
   [Sottile, Francesco; Bruno, Maurizio] Univ Palermo, Interdept Res Ctr Biobased Reuse Waste Agrifood Ma, Viale Sci, I-90128 Palermo, PA, Italy.
   [Napolitano, Assunta; Piacente, Sonia] Univ Salerno, Dept Pharm, I-84084 Fisciano, SA, Italy.
   [Badalamenti, Natale; Bruno, Maurizio] Univ Palermo, Dept Biol Chem & Pharmaceut Sci & Technol, Viale Sci, Parco Orleans 2, I-90128 Palermo, PA, Italy.
   [Bruno, Maurizio] Natl Biodivers Future Ctr, NBFC, I-90133 Palermo, PA, Italy.
   [Tundis, Rosa; Loizzo, Monica Rosa] Univ Calabria, Dept Pharm Hlth & Nutr Sci, I-87036 Arcavacata Di Rende, CS, Italy.
C3 University of Palermo; University of Palermo; University of Salerno;
   University of Palermo; National Biodiversity Future Center; University
   of Calabria
RP Loizzo, MR (corresponding author), Univ Calabria, Dept Pharm Hlth & Nutr Sci, I-87036 Arcavacata Di Rende, CS, Italy.
EM monica_rosa.loizzo@unical.it
RI Badalamenti, Natale/ADQ-4075-2022; Sottile, Francesco/I-8115-2019
OI Tundis, Rosa/0000-0002-3713-4403; Loizzo, Monica
   Rosa/0000-0002-6050-9357; PIACENTE, Sonia/0000-0002-4998-2311;
   Badalamenti, Natale/0000-0001-7961-3894; Sottile,
   Francesco/0000-0002-7774-6172; Bruno, Maurizio/0000-0003-0583-0487
FU European Union Next-Generation EU [D43C22001260001];  [B73C22000790001];
    [CN00000033]
FX This research was carried out within the National Biodiversity Future
   Center S.c.a.r.l., Piazza Marina 61 (c/o Palazzo Steri) Palermo, Italy,
   and received funding from the European Union Next-Generation EU (PIANO
   NAZIONALE DI RIPRESA E RESILIENZA (PNRR)-MISSIONE 4 COMPONENTE 2,
   INVESTIMENTO 1.4, C.I. CN00000033)-CUP UNIPA B73C22000790001; CUP UNISA
   D43C22001260001.
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NR 84
TC 7
Z9 8
U1 0
U2 9
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2304-8158
J9 FOODS
JI Foods
PD MAR
PY 2023
VL 12
IS 5
AR 1107
DI 10.3390/foods12051107
PG 22
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA 9U8KL
UT WOS:000947953600001
PM 36900625
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Andersson, M
   Haglund, E
   Aili, K
   Bremander, A
   Bergman, S
AF Andersson, Maria
   Haglund, E.
   Aili, K.
   Bremander, A.
   Bergman, S.
TI Associations between metabolic factors and radiographic knee
   osteoarthritis in early disease-a cross-sectional study of individuals
   with knee pain
SO BMC MUSCULOSKELETAL DISORDERS
LA English
DT Article
DE Knee pain; Knee osteoarthritis; Metabolic factors
ID MECHANICAL-STRESS; SEX-DIFFERENCES; INFLAMMATION; PREVALENCE; OBESITY;
   COMPONENTS; SYNOVITIS; JOINT; BODY; HIP
AB Objective Metabolic factors have been shown to be associated to severe radiographic knee osteoarthritis (RKOA). However, more knowledge is needed in early clinical knee osteoarthritis (KOA). The aim was to study associations between metabolic factors and radiographic knee osteoarthritis (OA) in individuals with knee pain. A second aim was to study associations between metabolic factors and RKOA in those with normal BMI and in those overweight/obese, respectively. Method This cross-sectional study included 282 individuals with knee pain (without cruciate ligament injury) and aged 30-67 years, and 70% women. Waist circumference, body mass index (BMI), proportion of fat and visceral fat area (VFA) were assessed. RKOA was defined as Ahlback grade 1 in at least one knee. Fasting blood samples were taken and triglycerides, cholesterol (total, low density lipoprotein (LDL) and high density lipoprotein (HDL)), C-reactive protein (CRP), glucose, HbA1C were analysed. Metabolic syndrome was defined in accordance with the International Diabetes Federation (IDF). Associations were analysed by logistic regression. Results Individuals with RKOA were older, had higher BMI, higher VFA, larger waist circumference and had increased total cholesterol, triglycerides and LDL-cholesterol, but not fasting glucose. There was no difference between the group with RKOA vs. non-radiographic group regarding the presence of metabolic syndrome. In a subgroup analysis of individuals with normal BMI (n = 126), those with RKOA had higher VFA, more central obesity, higher levels of CRP and total cholesterol, compared with individuals without RKOA. In individuals with obesity, age was the only outcome associated to RKOA. Conclusion There were clear associations between metabolic factors and RKOA in individuals with knee pain, also in those with normal BMI. In individuals with obesity age was the only variable associated to RKOA.
C1 [Andersson, Maria; Haglund, E.; Bremander, A.] Lund Univ, Rheumatol, Dept Clin Sci, Lund, Sweden.
   [Andersson, Maria; Haglund, E.; Aili, K.; Bremander, A.; Bergman, S.] Spenshult Res & Dev Ctr, Halmstad, Sweden.
   [Haglund, E.] Halmstad Univ, Sch Business Innovat & Sustainabil, Halmstad, Sweden.
   [Aili, K.] Halmstad Univ, Sch Hlth & Welf, Halmstad, Sweden.
   [Aili, K.] Karolinska Inst, Inst Environm Med, Stockholm, Sweden.
   [Bremander, A.] Univ Southern Denmark, Dept Reg Hlth Res, Odense, Denmark.
   [Bremander, A.] Univ Hosp Southern Denmark, Danish Hosp Rheumat Dis, Sonderborg, Denmark.
   [Bergman, S.] Univ Gothenburg, Sahlgrenska Acad, Sch Publ Hlth & Community Med Primary Hlth Care, Inst Med, Gothenburg, Sweden.
C3 Lund University; Halmstad University; Halmstad University; Karolinska
   Institutet; University of Southern Denmark; University of Southern
   Denmark; Odense University Hospital; University of Gothenburg
RP Andersson, M (corresponding author), Lund Univ, Rheumatol, Dept Clin Sci, Lund, Sweden.; Andersson, M (corresponding author), Spenshult Res & Dev Ctr, Halmstad, Sweden.
EM maria.andersson@fou-spenshult.se
OI Bremander, Ann/0000-0002-8081-579X; Aili, Katarina/0000-0003-4260-7399
FU Swedish Rheumatism Association [R-531621, R-635431, R-939824, R-967899];
   Crafoord Foundation; Lund University
FX The study was funded by the Swedish Rheumatism Association, grant number
   R-531621, R-635431, R-939824, R-967899, Targeted investment from the
   Swedish Rheumatism Association - Osteoarthritis from 2014 to 2019, and
   the Crafoord Foundation. The funders have not influenced the study
   design, collection, analysis, or interpretation of data, nor the writing
   of the manuscript or the decision to submit the manuscript for
   publication. Open access funding provided by Lund University.
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NR 53
TC 14
Z9 14
U1 1
U2 7
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2474
J9 BMC MUSCULOSKEL DIS
JI BMC Musculoskelet. Disord.
PD OCT 28
PY 2022
VL 23
IS 1
AR 938
DI 10.1186/s12891-022-05881-x
PG 11
WC Orthopedics; Rheumatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Rheumatology
GA 5U0VI
UT WOS:000876271800005
PM 36307803
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Szabó, K
   Gesztelyi, R
   Lampé, N
   Kiss, R
   Remenyik, J
   Pesti-Asbóth, G
   Priksz, D
   Szilvássy, Z
   Juhász, B
AF Szabo, Katalin
   Gesztelyi, Rudolf
   Lampe, Nora
   Kiss, Rita
   Remenyik, Judit
   Pesti-Asboth, Georgina
   Priksz, Daniel
   Szilvassy, Zoltan
   Juhasz, Bela
TI Fenugreek (Trigonella Foenum-Graecum) Seed Flour and Diosgenin Preserve
   Endothelium-Dependent Arterial Relaxation in a Rat Model of Early-Stage
   Metabolic Syndrome
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE endothelial dysfunction; metabolic syndrome; obesity; type 2 diabetes
   mellitus; fenugreek; Trigonella foenum-graecum; diosgenin;
   endothelium-dependent vasorelaxation; Wistar rat
ID NITRIC-OXIDE SYNTHASE; OXIDATIVE STRESS; SMOOTH-MUSCLE;
   CARDIOVASCULAR-DISEASE; INSULIN-RESISTANCE; DOWN-REGULATION;
   ADIPOSE-TISSUE; DIETARY FIBER; ECTOPIC FAT; DYSFUNCTION
AB Fenugreek is a common herb possessing several bioactive components including diosgenin. Here, dietary fenugreek seed flour and diosgenin were evaluated on a model of endothelium-dependent vasorelaxation by abdominal aortas isolated from rats receiving high-fat, high-sugar diet (HFHSD). 60 male Wistar rats were randomized into six groups: (i) negative control getting conventional rat feed regimen; (ii) positive control receiving HFHSD; (iii) a test group fed 2 g/kg bw/day fenugreek seed flour (containing 10 mg/kg bw/day diosgenin) + HFHSD; (iv) three test groups fed 1, 10 and 50 mg/kg bw /day diosgenin + HFHSD. Alimentary treatments were carried out for six weeks. The abdominal aortas were isolated, and 2 mm wide rings were sectioned off and mounted at a resting tension of 10 mN in organ baths containing Krebs solution (36 degrees C) exposed to 95% 0 2 and 5% CO2. After 60-min incubation, a norepinephrine concentration-response (E/c) curve was generated to determine their half-maximal effective concentration (EC50) value. After 60-min wash-out, a pre-contraction with norepinephrine EC50 was made, followed by an acetylcholine E/c curve. Plasma glutathione levels, glutathione-handling enzyme activities and blood antioxidant capacities were also determined. HFHSD significantly decreased the dilatory response to acetylcholine and increased plasma glutathione levels and these effects were significantly reversed by fenugreek seed flour, 10 and 50 mg/kg bw/day diosgenin. Both fenugreek and diosgenin treatments prevent HFHSD-induced endothelial dysfunction and redox changes. As fenugreek treatment was more effective at lower acetylcholine concentrations than diosgenin treatments, components of fenugreek other than diosgenin may contribute to the beneficial effects of dietary fenugreek seed flour.
C1 [Szabo, Katalin; Gesztelyi, Rudolf; Lampe, Nora; Kiss, Rita; Priksz, Daniel; Szilvassy, Zoltan; Juhasz, Bela] Univ Debrecen, Fac Med, Dept Pharmacol & Pharmacotherapy, Nagyerdei Krt 98, H-4032 Debrecen, Hungary.
   [Remenyik, Judit; Pesti-Asboth, Georgina] Univ Debrecen, Fac Agr & Food Sci & Environm Management, Inst Food Technol, Boszormenyi Ut 138, H-4032 Debrecen, Hungary.
C3 University of Debrecen; University of Debrecen
RP Juhász, B (corresponding author), Univ Debrecen, Fac Med, Dept Pharmacol & Pharmacotherapy, Nagyerdei Krt 98, H-4032 Debrecen, Hungary.
EM szabo.katalin@pharm.unideb.hu; gesztelyi.rudolf@pharm.unideb.hu;
   lampenori@gmail.com; kiss.rita@med.unideb.hu; remenyik@agr.unideb.hu;
   georgina.asboth@gmail.com; priksz.daniel@pharm.unideb.hu;
   szilvassy.zoltan@med.unideb.hu; juhasz.bela@med.unideb.hu
RI Gesztelyi, Rudolf/GSD-4399-2022; Kiss, Rita/U-1275-2019
OI Kiss, Rita/0000-0003-1208-366X; Gesztelyi, Rudolf/0000-0001-7911-055X;
   Priksz, Daniel/0000-0002-5818-4557
FU European Union; European Regional Development Fund; 
   [GINOP-2.3.2-15-2016-00062];  [AGR-PIAC-13-1-2013-0008]
FX The work/publication is supported by the GINOP-2.3.2-15-2016-00062
   project. The project is co-financed by the European Union and the
   European Regional Development Fund. This work was also supported in part
   by AGR-PIAC-13-1-2013-0008. The authors are sincerely grateful to
   Stephanie C. Fox, of QueenBeeEdit in Bloomfield, CT, USA, for her hard
   work in organizing, formatting, and editing this article.
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NR 75
TC 20
Z9 21
U1 0
U2 3
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD MAR
PY 2018
VL 19
IS 3
AR 798
DI 10.3390/ijms19030798
PG 21
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA GA4OO
UT WOS:000428309800155
PM 29534453
OA Green Submitted, gold, Green Published
DA 2025-06-11
ER

PT J
AU Jankovic, A
   Korac, A
   Srdic-Galic, B
   Buzadzic, B
   Otasevic, V
   Stancic, A
   Vucetic, M
   Markelic, M
   Velickovic, K
   Golic, I
   Korac, B
AF Jankovic, Aleksandra
   Korac, Aleksandra
   Srdic-Galic, Biljana
   Buzadzic, Biljana
   Otasevic, Vesna
   Stancic, Ana
   Vucetic, Milica
   Markelic, Milica
   Velickovic, Ksenija
   Golic, Igor
   Korac, Bato
TI Differences in the redox status of human visceral and subcutaneous
   adipose tissues - relationships to obesity and metabolic risk
SO METABOLISM-CLINICAL AND EXPERIMENTAL
LA English
DT Article
DE Redox regulation; Metabolism; Metabolic syndrome
ID INCREASED OXIDATIVE STRESS; LOW-DENSITY-LIPOPROTEIN; INSULIN-RESISTANCE;
   REGIONAL DIFFERENCES; IN-VIVO; GLUCOSE-UPTAKE; NORMAL-WEIGHT;
   GLUTATHIONE; EXPRESSION; DYSFUNCTION
AB Objective. Metabolic homeostasis depends on adipocyte metabolic responses/processes, most of which are redox-regulated. Besides, visceral and subcutaneous adipose tissues (VAT and SAT, respectively) differ metabolically and in their contribution to metabolic complications, but their redox characteristics in humans are still unknown. To understand the molecular mechanisms of metabolic syndrome development, we analysed the redox characteristics of VAT and SAT in groups with various body weights and metabolic risks.
   Material and Methods. Fifty premenopausal women were classified according to body mass index into normal-weight and obese groups, and these groups were further sub-classified into metabolically healthy and metabolically obese ("at risk") based on the homeostasis model assessment of insulin resistance (HOMA-IR) index and the triglyceride, total-, LDL- and HDL-cholesterol levels. Antioxidant components, NADPH oxidase protein and 4-hydroxynonenal (4-HNE) levels were analysed in VAT and SAT.
   Results. Compared with the SAT, the VAT showed a higher basal level of glutathione (GSH) and GSH-dependent enzyme activities. Compared with the metabolically healthy normal-weight controls, the obese groups of women showed lower GSH levels in both depots. However, in these groups, additional prooxidative changes (increased NADPH oxidase and 4-HNE and decreased levels of SOD and/or CAT) were observed only in VAT.
   Conclusions. Because of the critical role of thiol-redox homeostasis in lipogenesis, interdepot-differences in the GSH-dependent antioxidant part may be connected to the higher metabolic activity found in VAT. Analogously, the lower GSH levels that occur during obesity and the corresponding additional redox imbalance may be signs of VAT metabolic dysfunction that underlie the subsequent metabolic impairment. (C) 2014 Elsevier Inc. All rights reserved.
C1 [Jankovic, Aleksandra; Buzadzic, Biljana; Otasevic, Vesna; Stancic, Ana; Vucetic, Milica; Korac, Bato] Univ Belgrade, Inst Biol Res Sinisa Stankovic, Dept Physiol, Belgrade 11060, Serbia.
   [Korac, Aleksandra; Markelic, Milica; Velickovic, Ksenija; Golic, Igor] Univ Belgrade, Fac Biol, Ctr Electron Microscopy, Belgrade 11000, Serbia.
   [Srdic-Galic, Biljana] Univ Novi Sad, Fac Med, Dept Anat, Novi Sad 21000, Serbia.
C3 University of Belgrade; University of Belgrade; University of Novi Sad
RP Korac, B (corresponding author), Univ Belgrade, Inst Biol Res Sinisa Stankovic, Dept Physiol, Bulevar Despota Stefana 142, Belgrade 11060, Serbia.
EM koracb@ibiss.bg.ac.rs
RI Korac, Bato/AAH-8206-2021; Stancic, Ana/AAA-8051-2019; Markelić,
   Milica/S-7451-2019; Golic, Igor/B-4492-2009; Jankovic,
   Aleksandra/ACV-5778-2022; Otasevic, Vesna/U-2242-2017
OI Golic, Igor/0000-0001-5944-5053; Stancic, Ana/0000-0003-0806-0799;
   Markelic, Milica/0000-0002-5444-7735; Jankovic,
   Aleksandra/0000-0002-6945-927X; Srdic Galic,
   Biljana/0000-0001-7716-9072; Otasevic, Vesna/0000-0001-8660-8284; Korac,
   Bato/0000-0001-5272-579X
FU Ministry of Education, Science and Technological Development of the
   Republic of Serbia [173054, 173055]
FX This work was supported by the Ministry of Education, Science and
   Technological Development of the Republic of Serbia, Grants No 173054
   and 173055.
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NR 72
TC 53
Z9 58
U1 0
U2 11
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0026-0495
EI 1532-8600
J9 METABOLISM
JI Metab.-Clin. Exp.
PD MAY
PY 2014
VL 63
IS 5
BP 661
EP 671
DI 10.1016/j.metabol.2014.01.009
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA AG1UC
UT WOS:000335200700009
PM 24582138
DA 2025-06-11
ER

PT J
AU Cai, WJ
   Uribarri, J
   Zhu, L
   Chen, X
   Swamy, S
   Zhao, ZS
   Grosjean, F
   Simonaro, C
   Kuchel, GA
   Schnaider-Beeri, M
   Woodward, M
   Striker, GE
   Vlassara, H
AF Cai, Weijing
   Uribarri, Jaime
   Zhu, Li
   Chen, Xue
   Swamy, Shobha
   Zhao, Zhengshan
   Grosjean, Fabrizio
   Simonaro, Calogera
   Kuchel, George A.
   Schnaider-Beeri, Michal
   Woodward, Mark
   Striker, Gary E.
   Vlassara, Helen
TI Oral glycotoxins are a modifiable cause of dementia and the metabolic
   syndrome in mice and humans
SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF
   AMERICA
LA English
DT Article
DE neural; insulin resistance; obesity; nutrition; caloric restriction
ID GLYCATION END-PRODUCTS; ALZHEIMERS-DISEASE PATIENTS; CALORIE
   RESTRICTION; INSULIN-RESISTANCE; AMYLOID-BETA; COGNITIVE FUNCTION;
   DIABETES-MELLITUS; POTENTIAL ROLE; BRAIN; METHYLGLYOXAL
AB Age-associated dementia and Alzheimer's disease (AD) are currently epidemic. Neither their cause nor connection to the metabolic syndrome (MS) is clear. Suppression of deacetylase survival factor sirtuin 1 (SIRT1), a key host defense, is a central feature of AD. Age-related MS and diabetes are also causally associated with suppressed SIRT1 partly due to oxidant glycotoxins [advanced glycation end products (AGEs)]. Changes in the modern diet include excessive nutrient-bound AGEs, such as neurotoxic methyl-glyoxal derivatives (MG). To determine whether dietary AGEs promote AD, we evaluated WT mice pair-fed three diets throughout life: low-AGE (MG(-)), MG-supplemented low-AGE (MG(+)), and regular (Reg) chow. Older MG(+)-fed mice, similar to old Reg controls, developed MS, increased brain amyloid-beta(42), deposits of AGEs, gliosis, and cognitive deficits, accompanied by suppressed SIRT1, nicotinamide phosphoribosyltransferase, AGE receptor 1, and PPAR gamma. These changes were not due to aging or caloric intake, as neither these changes nor the MS were present in age-matched, pair-fed MG(-)mice. The mouse data were enhanced by significant temporal correlations between high circulating AGEs and impaired cognition, as well as insulin sensitivity in older humans, in whom dietary and serum MG levels strongly and inversely associated with SIRT1 gene expression. The data identify a specific AGE (MG) as a modifiable risk factor for AD and MS, possibly acting via suppressed SIRT1 and other host defenses, to promote chronic oxidant stress and inflammation. Because SIRT1 deficiency in humans is both preventable and reversible by AGE reduction, a therapeutic strategy that includes AGE reduction may offer a new strategy to combat the epidemics of AD and MS.
C1 [Cai, Weijing; Zhu, Li; Chen, Xue; Swamy, Shobha; Zhao, Zhengshan; Grosjean, Fabrizio; Striker, Gary E.; Vlassara, Helen] Icahn Sch Med Mt Sinai, Dept Geriatr, Div Expt Diabet, New York, NY 10029 USA.
   [Uribarri, Jaime; Striker, Gary E.; Vlassara, Helen] Icahn Sch Med Mt Sinai, Dept Med, New York, NY 10029 USA.
   [Simonaro, Calogera] Icahn Sch Med Mt Sinai, Dept Human Genet, New York, NY 10029 USA.
   [Schnaider-Beeri, Michal] Icahn Sch Med Mt Sinai, Dept Psychiat, New York, NY 10029 USA.
   [Grosjean, Fabrizio; Kuchel, George A.] Univ Pavia, Dept Med, Div Nephrol, I-27100 Pavia, Italy.
   [Woodward, Mark] Univ Connecticut, Ctr Hlth, UConn Ctr Aging, Farmington, CT 06030 USA.
   [Woodward, Mark] George Inst, Professorial Unit, Sydney, NSW 2050, Australia.
C3 Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at
   Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of
   Medicine at Mount Sinai; University of Pavia; University of Connecticut;
   George Institute for Global Health
RP Vlassara, H (corresponding author), Icahn Sch Med Mt Sinai, Dept Geriatr, Div Expt Diabet, New York, NY 10029 USA.
EM helen.vlassara@mssm.edu
RI Woodward, Mark/L-6817-2017; ZHAO, Zhengshan/E-7414-2017; Uribarri,
   Jaime/ADX-7655-2022
OI Kuchel, George/0000-0001-8387-7040; uribarri, jaime/0000-0001-9826-1134
FU National Institutes of Health [AG23188, M01-RR-00071]
FX This work was supported by National Institutes of Health Grants AG23188
   (to H.V.) and M01-RR-00071 (to the GCRC of Icahn School of Medicine at
   Mount Sinai).
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NR 42
TC 137
Z9 142
U1 0
U2 51
PU NATL ACAD SCIENCES
PI WASHINGTON
PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA
SN 0027-8424
J9 P NATL ACAD SCI USA
JI Proc. Natl. Acad. Sci. U. S. A.
PD APR 1
PY 2014
VL 111
IS 13
BP 4940
EP 4945
DI 10.1073/pnas.1316013111
PG 6
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA AD9IX
UT WOS:000333579700062
PM 24567379
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Bell, LN
   Temm, CJ
   Saxena, R
   Vuppalanchi, R
   Schauer, P
   Rabinovitz, M
   Krasinskas, A
   Chalasani, N
   Mattar, SG
AF Bell, Lauren N.
   Temm, Constance J.
   Saxena, Rashmil
   Vuppalanchi, Raj
   Schauer, Philip
   Rabinovitz, Mordechai
   Krasinskas, Alyssa
   Chalasani, Naga
   Mattar, Samer G.
TI Bariatric Surgery-Induced Weight Loss Reduces Hepatic Lipid Peroxidation
   Levels and Affects Hepatic Cytochrome P-450 Protein Content
SO ANNALS OF SURGERY
LA English
DT Article
ID FATTY LIVER-DISEASE; NONALCOHOLIC STEATOHEPATITIS; METABOLIC SYNDROME;
   ARACHIDONIC-ACID; DRUG-METABOLISM; STEATOSIS; CYP2E1; RAT; EXPRESSION;
   CYP3A
AB Objective: To evaluate the effects of surgical weight loss on hepatic lipid peroxidation levels and cytochrome P-450 protein expression in patients with nonalcoholic fatty liver disease (NAFLD).
   Summary Background Data: NAFLD and nonalcoholic steatohepatitis (NASH) affect hepatic cytochrome P-450 (CYP) protein expression and activity, and CYP2E1 may play a role in the pathogenesis of NAFLD and NASH through induction of oxidative stress and lipid peroxidation. NAFLD and NASH are associated with increased systemic lipid peroxidation levels and elevated hepatic CYP2E1 activity, but hepatic CYP3A4/5 activity is decreased.
   Methods: Liver biopsies from 20 patients with NAFLD who underwent bariatric surgery were obtained intraoperatively and at 15 +/- 7 months following surgery. Hepatic malondialdehyde (MDA) levels (a marker of lipid peroxidation), CYP2E1 and CYP3A4/5 protein expression, and steatosis, as a percent of total area, were measured by immunohistochemistry followed by digital image quantitation.
   Results: Following weight loss, as reflected by reduced BMI (54 +/- 9 vs. 37 +/- 9 kg/m(2); P < 0.001), features of the metabolic syndrome, grade and stage of liver disease, and liver histology were all significantly improved (P < 0.01). Hepatic MDA staining (35 +/- 18% vs. 23 +/- 14%; P = 0.02), CYP2E1 protein content (68 +/- 9% vs. 56 +/- 11%; P < 0.001), and steatosis (17 +/- 7% vs. 2 +/- 3%; P < 0.001) were significantly reduced following weight loss. CYP3A4/5 protein content was unchanged (57 +/- 13% vs. 55 +/- 13%; P = 0.433). The reduction in lipid peroxidation was independently associated with changes in CYP2E1 protein expression after bariatric surgery (r = 0.477; P = 0.033).
   Conclusion: Elevations in hepatic lipid peroxidation and CYP2E1 expression that are seen in NAFLD improve significantly with weight loss induced by bariatric surgery.
C1 [Mattar, Samer G.] Indiana Univ, Sch Med, Dept Surg, Indianapolis, IN 46202 USA.
   [Bell, Lauren N.; Vuppalanchi, Raj; Chalasani, Naga] Indiana Univ, Div Clin Pharmacol, Indianapolis, IN 46202 USA.
   [Bell, Lauren N.; Vuppalanchi, Raj; Chalasani, Naga] Indiana Univ, Div Gastroenterol Hepatol, Indianapolis, IN 46202 USA.
   [Temm, Constance J.; Saxena, Rashmil] Indiana Univ, Dept Pathol & Lab Med, Indianapolis, IN 46202 USA.
   [Schauer, Philip] Cleveland Clin, Dept Gen Surg, Bariatr & Metab Inst, Cleveland, OH 44106 USA.
   [Rabinovitz, Mordechai] Univ Pittsburgh, Dept Gastroenterol & Hepatol, Pittsburgh, PA USA.
   [Krasinskas, Alyssa] Univ Pittsburgh, Dept Pathol, Pittsburgh, PA USA.
C3 Indiana University System; Indiana University Indianapolis; Indiana
   University System; Indiana University Indianapolis; Indiana University
   System; Indiana University Indianapolis; Indiana University System;
   Indiana University Indianapolis; Cleveland Clinic Foundation;
   Pennsylvania Commonwealth System of Higher Education (PCSHE); University
   of Pittsburgh; Pennsylvania Commonwealth System of Higher Education
   (PCSHE); University of Pittsburgh
RP Mattar, SG (corresponding author), Indiana Univ, Sch Med, Dept Surg, 545 Barnhill Dr,EH523, Indianapolis, IN 46202 USA.
EM smattar@iupui.edu
RI Vuppalanchi, Raj/AAI-2482-2021
OI Vuppalanchi, Raj/0000-0003-0637-1577; Schauer,
   Philip/0000-0002-4029-7537
FU Clinical Pharmacology Training Grant [T32 GM08425];  [K24 DK072101]
FX Supported in part by K24 DK072101 (to N. C.) and supported by Clinical
   Pharmacology Training Grant to Indiana University (T32 GM08425) (to L.
   N. B.).
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NR 38
TC 54
Z9 59
U1 1
U2 11
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0003-4932
EI 1528-1140
J9 ANN SURG
JI Ann. Surg.
PD JUN
PY 2010
VL 251
IS 6
BP 1041
EP 1048
DI 10.1097/SLA.0b013e3181dbb572
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 608DE
UT WOS:000278561700009
PM 20485142
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Chen, S
   Wu, FH
   Yang, CC
   Zhao, C
   Cheng, N
   Cao, W
   Zhao, HA
AF Chen, Sinan
   Wu, Fanhua
   Yang, Chenchen
   Zhao, Cheng
   Cheng, Ni
   Cao, Wei
   Zhao, Haoan
TI Alternative to Sugar, Honey Does Not Provoke Insulin Resistance in Rats
   Based on Lipid Profiles, Inflammation, and IRS/PI3K/AKT Signaling
   Pathways Modulation
SO JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
LA English
DT Article
DE insulin resistance (IR); sugar-equivalent honey; phenolics; IRS/PI3K/AKT
   signaling pathway; inflammation
ID METABOLIC SYNDROME; GUT MICROBIOTA; FRUCTOSE; OBESITY; LIVER;
   ACCUMULATION; INHIBITION; HEALTH; CELLS; MICE
AB Insulin resistance (IR) is the central link to metabolic syndrome (MS), and IR prevention has become the key to overcoming this worldwide public health problem. A diet rich in simple sugars is an important pathogenic factor in IR development. To investigate the effect of honey on IR compared to the sugar-water diet, we analyzed phenolics and oligosaccharides in jujube honey and rape honey based on LC-MS and silane derivatization/GC-MS. The effects of different diets on glucose and lipid profile, histopathology and IR-related mechanism pathways were analyzed and compared by equal sugar levels intervention of fructose, fructose + glucose and two kinds of unifloral honey (high-/low-dose) in rats. The results suggested that sugar-equivalent honey, which differs from sugar solution, especially 17.1 g/kg BW jujube honey rich in phenolics (1.971 mg/100 g of isoquercitrin) and oligosaccharides (2.18 g/100 g of turanose), suppressed IR via maintaining glucose (OGTT and ITT) and lipid (TC, TG, LDL-C, HDL-C, and NEFA) homeostasis, improving histological structural abnormalities of the liver, adipose and skeletal muscle, reducing oxidative stress (GSH-Px and MDA) and inflammation (IL-6 and TNF-alpha), modulating the NF-kappa B (NF-kappa B gene expression was down-regulated to 0.94) and IRS/PI3K/AKT signaling pathways (e.g., AKT and GLUT2 expression in liver increased by 4.56 and 13.37 times, respectively) as well as reshaping the gut microbiota. These revealed a potential nutritional contribution of substituting honey for simple sugar in the diet, providing a theoretical basis for controlling IR development via dietary modification and supplementation.
C1 [Chen, Sinan; Wu, Fanhua; Yang, Chenchen; Zhao, Cheng; Cheng, Ni; Cao, Wei; Zhao, Haoan] Northwest Univ, Coll Food Sci & Technol, Xian 710069, Peoples R China.
   [Cheng, Ni; Cao, Wei] Bee Prod Res Ctr Shaanxi Prov, Xian 710065, Peoples R China.
C3 Northwest University Xi'an
RP Cao, W; Zhao, HA (corresponding author), Northwest Univ, Coll Food Sci & Technol, Xian 710069, Peoples R China.; Cao, W (corresponding author), Bee Prod Res Ctr Shaanxi Prov, Xian 710065, Peoples R China.
EM caowei@nwu.edu.cn; zhaohaoan@nwu.edu.cn
RI Zhao, Haoan/U-8687-2018; cheng, ni/JHS-9486-2023
OI Zhao, Haoan/0000-0001-7071-9385
FU National Natural Science Foundation of China [31871876, 31901786];
   Shaanxi High-Level Talent Special Support Plan [TZ0389]; Shaanxi Science
   & Technology Project [2022FP-12, 2022FP-14]
FX The authors thank Daidi Fan, Chenhui Zhu, and Jingjing Shao (School of
   Chemical Engineering, Northwest University, China) for the technical
   support in western blot analysis. This work was jointly supported by the
   National Natural Science Foundation of China (No. 31871876 and No.
   31901786) ; the Shaanxi High-Level Talent Special Support Plan (TZ0389)
   ; and the Shaanxi Science & Technology Project (2022FP-12 and 2022FP-14)
   .
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NR 64
TC 18
Z9 19
U1 5
U2 56
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0021-8561
EI 1520-5118
J9 J AGR FOOD CHEM
JI J. Agric. Food Chem.
PD AUG 24
PY 2022
VL 70
IS 33
BP 10194
EP 10208
DI 10.1021/acs.jafc.2c03639
PG 15
WC Agriculture, Multidisciplinary; Chemistry, Applied; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture; Chemistry; Food Science & Technology
GA 4E5CX
UT WOS:000847844300001
PM 35971648
DA 2025-06-11
ER

PT J
AU Novello, G
   Segabinazzi, LGTM
   Lisboa, FP
   Canuto, LE
   Freitas-Dell'Aqua, CP
   Dell'Aqua, JA
   Canisso, IF
AF Novello, Guilherme
   Segabinazzi, Lorenzo G. T. M.
   Lisboa, Fernando P.
   Canuto, Lucas E.
   Freitas-Dell'Aqua, Camilla P.
   Dell'Aqua Jr, Jose A.
   Canisso, Igor F.
TI High or Low Body Fat Deposition in the Presence of a Normal Oral Sugar
   Test is Not Associated With Postthaw Semen Parameters in Stallions
SO JOURNAL OF EQUINE VETERINARY SCIENCE
LA English
DT Article
DE Sperm; Cryopreservation; Metabolic syndrome; Obesity; Horse
ID OXIDATIVE STRESS; OBESITY; SPERM; PLASMA; HORMONE; INSULIN; HORSES;
   SCORE
AB This study compared the postthaw semen parameters of stallions with high and low body condition score (BCS) and evaluated associations between body morphometric parameters and postthaw semen parameters. Twenty stallions were split into Low BCS (BCS<7, n = 11) and High BCS (BCS >= 7, n = 9) groups, and underwent a complete morphometric analysis (e.g., neck scores and circumference, crest neck height, body weight, and height), and subcutaneous body fat thickness (SFT) at the tail head, withers, shoulders, and retroperitoneal space. A fasted oral sugar test (OST) was conducted on all stallions. One ejaculate from each stallion was frozen with a commercial egg yolk-based extender. Postthaw sperm motility parameters, plasma membrane integrity, mitochondrial membrane potential, hydrogen peroxide and intracellular superoxide production, and lipid peroxidation were analyzed for all stallions. The circumference at 25% and 50% of the neck's length were larger for High-BCS stallions (P < .05). There were no differences between groups for the neck crest height (P > .05). Stallions with High BCS had greater SFT at the tail head than stallions with Low BCS (P < .05); however, there were no differences between groups in the SFT at the shoulders and withers (P > .05). All stallions had resting blood glucose below the cutoff for equine metabolic syndrome. There were no differences between groups for resting glucose concentrations or for a peak at 30 or 60 minutes after initiation of the OST (P > .05). There were no differences in sperm parameters between groups (P > .05). Collectively, the findings of the present study suggest that High BCS or Low BCS in the presence of normal OST do not explain post-thaw semen parameters. (C) 2020 Elsevier Inc. All rights reserved.
C1 [Novello, Guilherme; Segabinazzi, Lorenzo G. T. M.; Canuto, Lucas E.; Canisso, Igor F.] Univ Illinois, Coll Vet Med, Dept Vet Clin Med, 1008 W Hazelwood Dr, Urbana, IL 61802 USA.
   [Novello, Guilherme; Segabinazzi, Lorenzo G. T. M.; Lisboa, Fernando P.; Canuto, Lucas E.; Freitas-Dell'Aqua, Camilla P.; Dell'Aqua Jr, Jose A.] Sao Paulo State Univ, Sch Vet Med & Anim Sci, Dept Anim Reprod & Vet Radiol, Botucatu, Brazil.
C3 University of Illinois System; University of Illinois Urbana-Champaign;
   Universidade Estadual Paulista
RP Canisso, IF (corresponding author), Univ Illinois, Coll Vet Med, Dept Vet Clin Med, 1008 W Hazelwood Dr, Urbana, IL 61802 USA.
EM canisso@illinois.edu
RI Dell'Aqua, José/C-1164-2012; , Camila de Paula/A-4795-2008
OI Paixao Lisboa, Fernando/0000-0001-5157-1506; Canisso,
   Igor/0000-0003-3799-6641; Emanuel Ferreira Canuto,
   Lucas/0000-0001-5364-3921; Segabinazzi, Lorenzo/0000-0001-7526-7760;
   Dell'Aqua Jr., Jose Antonio/0000-0001-8758-3605; , Camila de
   Paula/0000-0002-4457-9160
FU Sao Paulo Research Foundation (FAPESP) [2015/25638-3]; Coordenaao de
   Aperfeicoamento de Pessoal de Nivel Superior - Brasil (CAPES) [001]
FX This study was partially funded by Sao Paulo Research Foundation
   (FAPESP, grant number 2015/25638-3) and by the Coordenaao de
   Aperfeicoamento de Pessoal de Nivel Superior - Brasil (CAPES) - Finance
   Code 001. The authors are grateful to the stud farms (Criadero Las
   Callanas & Os Charruas, Cabanha da Charqueada, Hartwig Fertilidade
   Equina, Retiro Reproducao Equina, Cabanha Tambore, Cabanha 66 and
   Schimitt & Gonzales Reproducao Equina) and veterinarians, Felipe
   Hartwig, Gabriel Florio, Alexandre Saatkamp Lavarda, Ricardo Gigena
   Wrege, Frederico Schmitt, Vanessa de Lima, and Jackson Fernando Colet
   for allowing us to use their animals in the study. Drs. Edgar Garret,
   Giorgia Podico and Robyn Ellerbrock are thanked for their critical
   reading of the manuscript.
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NR 27
TC 2
Z9 2
U1 0
U2 3
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0737-0806
EI 1542-7412
J9 J EQUINE VET SCI
JI J. Equine Vet. Sci.
PD DEC
PY 2020
VL 95
AR 103271
DI 10.1016/j.jevs.2020.103271
PG 9
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA PG1TI
UT WOS:000599524900020
PM 33276914
DA 2025-06-11
ER

PT J
AU Farhangi, MA
   Vajdi, M
AF Farhangi, Mahdieh Abbasalizad
   Vajdi, Mahdi
TI The association between dietary inflammatory index and risk of central
   obesity in adults: An updated systematic review and meta-analysis
SO INTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCH
LA English
DT Review
DE Dietary inflammatory index; waist circumference; waist to hip ratio;
   central obesity
ID LOW-GRADE INFLAMMATION; CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME;
   INSULIN-RESISTANCE; VISCERAL OBESITY; PATTERNS; MARKERS; CANCER;
   ATHEROSCLEROSIS; STRESS
AB Backgrounds: Central obesity, as a pivotal component of metabolic syndrome is associated with numerous co-morbidities. Dietary factors influence central obesity by increased inflammatory status. However, recent studies didn't evaluate the association between central obesity and dietary inflammation index (DII (R)) that give score to dietary factors according to their inflammatory potential. In the current systematic review and meta-analysis, we summarized the studies that investigated the association between De with central obesity indices in the general populations. Methods: In a systematic search from PubMed, SCOPUS, Web of Sciences and Cochrane electronic databases, we collected relevant studies written in English and published until 30 October 2019. The population of included studies were apparently healthy subjects or individuals with obesity or obesity-related diseases. Observational studies that evaluated the association between DII (R) and indices of central obesity including WC or WHR were included. Results: Totally thirty-two studies were included: thirty studies were cross-sectional and two were cohort studies with 103071 participants. Meta-analysis of observational studies showed that higher DII (R) scores were associated with 1.81 cm increase in WC (Pooled weighted mean difference (WMD) = 1.813; CI: 0.785-2.841: p = 0.001). Also, a non-significant increase in the odds of having higher WC (OR = 1.162; CI: 0.95-1.43; p = 0.154) in the highest DII (R) category was also observed. In subgroup analysis, the continent, dietary assessment toot and gender were the heterogeneity sources. Conclusion: The findings proposed that adherence to diets with high DII (R) scores was associated with increased WC. Further studies with interventional designs are necessary to elucidate the causality inference between DII (R) and central obesity indices.
C1 [Farhangi, Mahdieh Abbasalizad] Tabriz Univ Med Sci, Nutr Res Ctr, Tabriz, Iran.
   [Farhangi, Mahdieh Abbasalizad] Tabriz Univ Med Sci, Drug Appl Res Ctr, Tabriz, Iran.
   [Vajdi, Mahdi] Tabriz Univ Med Sci, Res Ctr Evidence Based Med, Hlth Management & Safety Promot Res Inst, Tabriz, Iran.
C3 Tabriz University of Medical Science; Tabriz University of Medical
   Science; Tabriz University of Medical Science
RP Farhangi, MA (corresponding author), Daneshgah Blv, Tabriz, Iran.
EM abbasalizad_m@yahoo.com
RI Vajdi, Mahdi/GZG-7674-2022; Farhangi, Mahdieh/AAC-6758-2019
OI Vajdi, Mahdi/0000-0002-2828-1161
FU Tabriz University of Medical Sciences [IR.TBZMED.REC.1397.298]
FX The work has been funded by a grant from Tabriz University of Medical
   Sciences (Registration number: IR.TBZMED.REC.1397.298).
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NR 89
TC 25
Z9 26
U1 0
U2 5
PU HOGREFE AG-HOGREFE AG SUISSE
PI BERN
PA LANGGASS STRASSE 76, BERN, SWITZERLAND
SN 0300-9831
EI 1664-2821
J9 INT J VITAM NUTR RES
JI Int. J. Vitam. Nutr. Res.
PD OCT
PY 2020
VL 90
IS 5-6
BP 535
EP 552
DI 10.1024/0300-9831/a000648
PG 18
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA NZ6AX
UT WOS:000577189800018
PM 32129728
DA 2025-06-11
ER

PT J
AU Belli, AA
   Kara, A
   Gok, SO
AF Belli, Asli Akin
   Kara, Asude
   Gok, Seyran Ozbas
TI Can Hematologic Parameters be an Indicator of Metabolic Disorders
   Accompanying Rosacea?
SO ACTA DERMATOVENEROLOGICA CROATICA
LA English
DT Article
DE hematologic parameters; insulin resistance; metabolic syndrome; rosacea
ID NEUTROPHIL-LYMPHOCYTE RATIO; INTIMA MEDIA THICKNESS; INSULIN-RESISTANCE;
   CHOLESTEROL RATIO; DISEASE; RISK; INFLAMMATION; SEVERITY; STRESS;
   ASSOCIATION
AB Recently, diverse hematologic parameters have been used as an indicator of the presence or severity of inflammatory and cardiovascular diseases. Our aim was to investigate the ratios of neutrophils to lymphocytes (NL), monocytes to high-density lipoprotein (HDL) cholesterol (MHC), and platelets to lymphocytes (PL) in patients with rosacea in comparison with the control group and determine whether there was a correlation between these ratios and metabolic disorders in patients with rosacea. We conducted a case-control study on 61 patients with rosacea and 60 healthy controls between January 2015 and January 2016 at the Dermatology Outpatient Clinic, Mugla, Turkey. Demographic data, biochemical parameters, hematologic parameters and ratios, the presence of metabolic syndrome (MS), and the presence of insulin resistance (IR) in the participants were recorded. Sixty one patients with rosacea (16 men, 45 women) and 60 controls (13 men, 47 women) were included in the study. The NL ratio, mean levels of low-density lipoprotein (LDL) and total cholesterol, triglyceride, C-reactive protein (CRP), systolic and diastolic blood pressures, and the presence of IR were significantly higher in patients with rosacea than in controls. In the rosacea group, the MHC ratio was significantly higher in patients with rosacea with IR and MS. Moreover, only the MHC ratio was an independent predictor of MS according to univariate logistic regression analysis. The cutoff value of MHC on admission for predicting MS in patients with rosacea was 0.013.The higher levels of NL ratio and IR in the rosacea group corroborate the previous studies demonstrating a high level of cardiovascular risk factors in patients with rosacea. The MHC ratio may be used as a simple and inexpensive method to predict metabolic disorders in patients with rosacea.
C1 [Belli, Asli Akin; Kara, Asude] Mugla Sitki Kocman Univ, Training & Res Hosp, Dept Dermatol, Mugla, Turkey.
   [Gok, Seyran Ozbas] Artvin Hopa State Hosp, Dept Dermatol, Artvin, Turkey.
C3 Mugla Sitki Kocman University; Hopa State Hospital; Artvin State
   Hospital
RP Belli, AA (corresponding author), Mugla Sitki Kocman Univ, Dept Dermatol, TR-48000 Mugla, Turkey.
EM dr_asliakin@hotmail.com
RI Polat, Asude/ABH-2234-2020
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NR 28
TC 16
Z9 16
U1 0
U2 1
PU CROATION DERMATOVENEROLOGICAL SOC
PI ZAGREB
PA ZAGREB UNIV HOSPITAL CTR, UNIV DEPT DERMATOLOGY & VENEROLOGY, SALATA 4,
   ZAGREB, 10000, CROATIA
SN 1330-027X
EI 1847-6538
J9 ACTA DERMATOVENER CR
JI Acta Dermatovenerol. Croat.
PY 2017
VL 25
IS 2
BP 145
EP 150
PG 6
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA FC3KF
UT WOS:000406736800009
PM 28871930
DA 2025-06-11
ER

PT J
AU Jung, CH
   Hwang, JY
   Yu, JH
   Shin, MS
   Bae, SJ
   Park, JY
   Kim, HK
   Lee, WJ
AF Jung, Chang Hee
   Hwang, Jenie Yoonoo
   Yu, Ji Hee
   Shin, Mi Seon
   Bae, Sung Jin
   Park, Joong-Yeol
   Kim, Hong-Kyu
   Lee, Woo Je
TI The value of apolipoprotein B/A1 ratio in the diagnosis of metabolic
   syndrome in a Korean population
SO CLINICAL ENDOCRINOLOGY
LA English
DT Article
ID NUTRITION EXAMINATION SURVEY; CARDIOVASCULAR RISK-FACTORS; A-I RATIO;
   MYOCARDIAL-INFARCTION; INSULIN-RESISTANCE; OXIDATIVE STRESS;
   NATIONAL-HEALTH; 52 COUNTRIES; PREVALENCE; MARKERS
AB Objective The ratio of apolipoprotein B (apoB) to apolipoprotein A1 (apoA1) has been reported to be associated with the metabolic syndrome (MetS). However, the optimal cut-off value of apoB/A1 ratio for detecting subjects with MetS has remained undetermined. In the present study, we aimed to investigate whether apoB/A1 ratio can be an indicator of MetS and to determine the optimal cut-off value of apoB/A1 ratio in detecting subjects with MetS in a Korean population. Design This cross-sectional study was conducted at the Asan Medical Center, Seoul, Republic of Korea. Subjects and measurements We collected the data of 10 940 subjects who participated in a routine health screening examination regarding conventional risk factors and serum levels of apoB and apoA1. Results The odds for MetS were significantly higher in the highest compared with the lowest apoB/A1 ratio quartiles, after adjustment for confounding variables, in both men [odds ratio (OR) = 4.07, 95% CI = 3.424.84] and women (OR = 8.41, 95% CI = 5.8512.08). The optimal apoB/A1 ratio cut-off value for the detection of MetS was 0.65, which had a sensitivity of 63.5% and a specificity of 61.3% (area under the curve = 0.67, 95% CI = 0.660.68, P < 0.001) in men and 0.62, which had a sensitivity of 67.9% and a specificity of 61.9% (area under the curve = 0.70, 95% CI = 0.690.71, P < 0.001) in women. Conclusions These results suggest that apoB/A1 ratio is independently associated with MetS and that an apoB/A1 ratio >0.65 in men and 0.62 in women is a marker of MetS independent from conventional risk factors.
C1 [Jung, Chang Hee; Hwang, Jenie Yoonoo; Yu, Ji Hee; Shin, Mi Seon; Park, Joong-Yeol; Lee, Woo Je] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Internal Med, Seoul 138736, South Korea.
   [Bae, Sung Jin; Kim, Hong-Kyu] Univ Ulsan, Coll Med, Asan Med Ctr, Hlth Screening & Promot Ctr, Seoul 138736, South Korea.
C3 University of Ulsan; Asan Medical Center; University of Ulsan; Asan
   Medical Center
RP Lee, WJ (corresponding author), Univ Ulsan, Coll Med, Asan Med Ctr, Dept Internal Med, 388-1 Poongnap Dong, Seoul 138736, South Korea.
EM hkkim0801@amc.seoul.kr; lwjat-las@naver.com
RI Jung, Chang/AAU-7897-2020; Kim, Seunghyun/AAA-3402-2022
OI Yu, Ji Hee/0000-0003-1907-2859; Jung, Chang Hee/0000-0003-4043-2396
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NR 35
TC 17
Z9 18
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0300-0664
EI 1365-2265
J9 CLIN ENDOCRINOL
JI Clin. Endocrinol.
PD NOV
PY 2012
VL 77
IS 5
BP 699
EP 706
DI 10.1111/j.1365-2265.2012.04329.x
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 017NI
UT WOS:000309596400011
PM 22211563
DA 2025-06-11
ER

PT J
AU Leow, SS
   Khoo, JS
   Lee, WK
   Hoh, CC
   Fairus, S
   Sambanthamurthi, R
   Hayes, KC
AF Leow, Soon-Sen
   Khoo, Jia-Shiun
   Lee, Wei-Kang
   Hoh, Chee-Choong
   Fairus, Syed
   Sambanthamurthi, Ravigadevi
   Hayes, K. C.
TI RNA-Seq transcriptome profiling of Nile rat livers reveals novel
   insights on the anti-diabetic mechanisms of Water-Soluble Palm Fruit
   Extract
SO JOURNAL OF APPLIED GENETICS
LA English
DT Article
DE Water-Soluble Palm Fruit Extract; Oil palm phenolics; Nile rats;
   Metabolic syndrome; Gene expression
ID TYPE-2 DIABETES-MELLITUS; INTESTINAL ALKALINE-PHOSPHATASE;
   GENE-EXPRESSION PROFILES; METABOLIC SYNDROME; INSULIN-SECRETION; MOUSE
   MODEL; GRASS RAT; PATHWAY; DIET; RISK
AB Water-Soluble Palm Fruit Extract (WSPFE) has been shown to confer anti-diabetic effects in the Nile rat (NR) (Arvicanthis niloticus). Liquid and powder WSPFE both deterred diabetes onset in NRs fed a high-carbohydrate (hiCHO) diet, but the liquid form provided better protection. In this study, NRs were fed either a hiCHO diet or the same diet added with liquid or powder WSPFE. Following feeding of the diets for 8 weeks, random blood glucose levels were measured to categorize NRs as either diabetes-resistant or diabetes-susceptible, based on a cut-off value of 75 mg/dL. Livers were then obtained for Illumina HiSeq 4000 paired end RNA-sequencing (RNA-Seq) and the data were mapped to the reference genome. Consistent with physiological and biochemical parameters, the gene expression data obtained indicated that WSPFE was associated with protection against diabetes. Among hepatic genes upregulated by WSPFE versus controls, were genes related to insulin-like growth factor binding protein, leptin receptor, and processes of hepatic metabolism maintenance, while those downregulated were related to antigen binding, immunoglobulin receptor, inflammation- and cancer-related processes. WSPFE supplementation thus helped inhibit diabetes progression in NRs by increasing insulin sensitivity and reducing both the inflammatory effects of a hiCHO diet and the related DNA-damage compensatory mechanisms contributing to liver disease progression. In addition, the genetic permissiveness of susceptible NRs to develop diabetes was potentially associated with dysregulated compensatory mechanisms involving insulin signaling and oxidative stress over time. Further studies on other NR organs associated with diabetes and its complications are warranted.
C1 [Leow, Soon-Sen; Fairus, Syed; Sambanthamurthi, Ravigadevi] Malaysian Palm Oil Board, 6 Persiaran Inst,Bandar Baru Bangi, Kajang 43000, Selangor, Malaysia.
   [Khoo, Jia-Shiun; Lee, Wei-Kang; Hoh, Chee-Choong] Codon Genom Sdn Bhd, 26 Jalan Dutamas 7 Taman Dutamas Balakong, Seri Kembangan 43200, Selangor, Malaysia.
   [Sambanthamurthi, Ravigadevi] Acad Sci Malaysia, Level 20,West Wing,MATRADE Tower,Jalan Sultan Haji, Kuala Lumpur 50480, Malaysia.
   [Hayes, K. C.] Brandeis Univ, 415 South St MS035, Waltham, MA 02454 USA.
C3 Malaysian Palm Oil Board; Brandeis University
RP Leow, SS (corresponding author), Malaysian Palm Oil Board, 6 Persiaran Inst,Bandar Baru Bangi, Kajang 43000, Selangor, Malaysia.
EM ssleow@mpob.gov.my; jiaxun@codongenomics.com;
   weikang.lee@codongenomics.com; ivan.hoh@codongenomics.com;
   syfairus@mpob.gov.my; ravigadevi@gmail.com; kchayes@brandeis.edu
RI Lee, Wei-Kang/J-6805-2016; Leow, Soon-Sen/P-2443-2019
OI Leow, Soon-Sen/0000-0002-8002-5376; Sambanthamurthi,
   Ravi/0000-0003-3023-9306
FU Malaysian Palm Oil Board
FX The authors thank MPOB support staff for assistance in preparing WSPFE.
   The technical assistance of Jabariah Md Ali and Chang Wooi Kai in
   extracting the NR total RNA samples in MPOB is also gratefully
   acknowledged. The authors also thank Alice Luu and Michelle Landstrom
   for their technical assistance in the care and handling of the NR
   breeding colony in the Hayes laboratory at Brandeis University.
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NR 156
TC 0
Z9 0
U1 1
U2 2
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1234-1983
EI 2190-3883
J9 J APPL GENET
JI J. Appl. Genetics
PD DEC
PY 2024
VL 65
IS 4
BP 867
EP 895
DI 10.1007/s13353-024-00880-1
EA JUN 2024
PG 29
WC Biotechnology & Applied Microbiology; Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Genetics & Heredity
GA M0H6K
UT WOS:001249374400001
PM 38890243
DA 2025-06-11
ER

PT J
AU Mirarchi, L
   Amodeo, S
   Citarrella, R
   Licata, A
   Soresi, M
   Giannitrapani, L
AF Mirarchi, Luigi
   Amodeo, Simona
   Citarrella, Roberto
   Licata, Anna
   Soresi, Maurizio
   Giannitrapani, Lydia
TI SGLT2 Inhibitors as the Most Promising Influencers on the Outcome of
   Non-Alcoholic Fatty Liver Disease
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE NAFLD; metabolic syndrome; type 2 diabetes mellitus; SGLT2
ID HEPATIC STEATOSIS; INFLAMMATORY BIOMARKERS; INSULIN-RESISTANCE;
   DIABETES-MELLITUS; AUTOPHAGY; STEATOHEPATITIS; FIBROSIS; ULTRASOUND;
   DIAGNOSIS; CANAGLIFLOZIN
AB Non-alcoholic fatty liver disease (NAFLD), the most frequent liver disease in the Western world, is a common hepatic manifestation of metabolic syndrome (MetS). A specific cure has not yet been identified, and its treatment is currently based on risk factor therapy. Given that the initial accumulation of triglycerides in the liver parenchyma, in the presence of inflammatory processes, mitochondrial dysfunction, lipotoxicity, glucotoxicity, and oxidative stress, can evolve into non-alcoholic steatohepatitis (NASH). The main goal is to identify the factors contributing to this evolution because, once established, untreated NASH can progress through fibrosis to cirrhosis and, ultimately, be complicated by hepatocellular carcinoma (HCC). Several drugs have been tested in clinical trials for use as specific therapy for NAFLD; most of them are molecules used to cure type 2 diabetes mellitus (T2DM), which is one of the main risk factors for NAFLD. Among the most studied is pioglitazone, either alone or in combination with vitamin E, glucagon-like peptide-1 (GLP-1) receptor agonists, dipeptidyl peptidase-4 (DPP-4) inhibitors. Actually, the most promising category seems to be sodium-glucose cotransporter (SGLT2) inhibitors. Their action is carried out by inhibiting glucose reabsorption in the proximal renal tubule, leading to its increased excretion in urine and decreased levels in plasma. Experimental studies in animal models have suggested that SGLT2 inhibitors may have beneficial modulatory effects on NAFLD/NASH, and several trials in patients have proven their beneficial effects on liver enzymes, BMI, blood lipids, blood glucose, and insulin resistance in NAFLD patients, thus creating strong expectations for their possible use in preventing the evolution of liver damage in these patients. We will review the main pathogenetic mechanisms, diagnostic modalities, and recent therapies of NAFLD, with particular attention to the use of SGLT2 inhibitors.
C1 [Mirarchi, Luigi; Amodeo, Simona; Citarrella, Roberto; Licata, Anna; Soresi, Maurizio; Giannitrapani, Lydia] Univ Palermo, Dept Hlth Promot Sci Maternal & Infant Care Inter, I-90127 Palermo, Italy.
   [Giannitrapani, Lydia] CNR, Inst Biomed Res & Innovat IRIB, I-90146 Palermo, Italy.
C3 University of Palermo; Consiglio Nazionale delle Ricerche (CNR);
   Istituto Ricerca l'Innovazione Biomedica (IRIB-CNR)
RP Giannitrapani, L (corresponding author), Univ Palermo, Dept Hlth Promot Sci Maternal & Infant Care Inter, I-90127 Palermo, Italy.; Giannitrapani, L (corresponding author), CNR, Inst Biomed Res & Innovat IRIB, I-90146 Palermo, Italy.
EM mirarchi.luigi@tiscali.it; simona.amodeo@unipa.it;
   roberto.citarrella@unipa.it; anna.licata@unipa.it;
   maurizio.soresi@unipa.it; lydia.giannitrapani@unipa.it
RI Giannitrapani, Lydia/I-3706-2019; Licata, Anna/ADF-0000-2022
OI AMODEO, SIMONA/0000-0002-2980-7372; Licata, Anna/0000-0003-0383-6121;
   Mirarchi, Luigi/0000-0001-7700-7129; Soresi,
   Maurizio/0000-0001-7850-555X
FU  [08TP1041100162];  [IRIS/U GOV 16463]
FX This work was supported by the project n. 08TP1041100162 named
   TRIAL"Code IRIS/U GOV 16463" "PO FESR Sicilia 2014-2020" to L.G.
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NR 94
TC 15
Z9 16
U1 0
U2 13
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD APR
PY 2022
VL 23
IS 7
AR 3668
DI 10.3390/ijms23073668
PG 15
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 0L2HW
UT WOS:000781302100001
PM 35409028
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Sotomayor, CG
   Oskooei, SS
   Bustos, NI
   Nolte, IM
   Gomes-Neto, AW
   Erazo, M
   Gormaz, JG
   Berger, SP
   Navis, GJ
   Rodrigo, R
   Dullaart, RPF
   Bakker, SJL
AF Sotomayor, Camilo G.
   Oskooei, Sara Sokooti
   Bustos, Nicolas I.
   Nolte, Ilja M.
   Gomes-Neto, Antonio W.
   Erazo, Marcia
   Gormaz, Juan G.
   Berger, Stefan P.
   Navis, Gerjan J.
   Rodrigo, Ramon
   Dullaart, Robin P. F.
   Bakker, Stephan J. L.
TI Serum uric acid is associated with increased risk of posttransplantation
   diabetes in kidney transplant recipients: a prospective cohort study
SO METABOLISM-CLINICAL AND EXPERIMENTAL
LA English
DT Article
DE Uric acid; Posttransplantation diabetes; Kidney transplantation;
   Inflammation; Oxidative stress; Metabolic syndrome
ID ENDOTHELIAL DYSFUNCTION; RENAL-TRANSPLANTATION; COMPETING RISKS;
   GLUCOSE-UPTAKE; HYPERURICEMIA; MELLITUS; SURVIVAL; INFLAMMATION;
   RECOMMENDATIONS; METABOLISM
AB Background: Serum uric acid (SUA) is associated with fasting glucose in healthy subjects, and prospective epidemological studies have shown that elevated SUA is associated with increased risk of type 2 diabetes. Whether SUA is independently associated with higher risk of posttransplantation diabetes mellitus (PTDM) in kidney transplant recipients (KTR) remains unknown.
   Methods: We performed a longitudinal cohort study of 524 adult KTR with a functioning graft >= 1-year, recruited at a university setting (2008-2011). Multivariable-adjusted Cox proportional-hazards regression analyses were performed to assess the association between time-updated SUA and risk of PTDM (defined according the American Diabetes Association's diagnostic criteria).
   Results: Mean (SD) SUA was 0.43 (0.11) mmol/L at baseline. During 5.3 (IQR, 4.1-6.0) years of follow-up, 52 (10%) KTR developed PTDM. In univariate prospective analyses, SUA was associated with increased risk of PTDM (HR 1.75, 95% CI 1.36-2.26 per 1-SD increment; P < 0.001). This finding remained materially unchanged after adjustment for components of the metabolic syndrome, lifestyle, estimated glomerular filtration rate, immunosuppressive therapy, cytomegalovirus and hepatitis C virus infection (HR 1.89, 95% CI 1.32-2.70; P = 0.001). These findings were consistent in categorical analyses, and robust in sensitivity analyses without outliers.
   Conclusions: In KTR, higher SUA levels are strongly and independently associated with increased risk of PTDM. Our findings are in agreement with accumulating evidence supporting SUA as novel independent risk marker for type 2 diabetes, and extend the evidence, for the first time, to the clinical setting of outpatient KTR. (C) 2020 The Author(s). Published by Elsevier Inc.
C1 [Sotomayor, Camilo G.; Oskooei, Sara Sokooti; Gomes-Neto, Antonio W.; Berger, Stefan P.; Navis, Gerjan J.; Bakker, Stephan J. L.] Univ Groningen, Univ Med Ctr Groningen, Dept Internal Med, Div Nephrol, Groningen, Netherlands.
   [Bustos, Nicolas I.; Erazo, Marcia; Gormaz, Juan G.; Rodrigo, Ramon] Univ Chile, Fac Med, Santiago, Chile.
   [Nolte, Ilja M.] Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, Groningen, Netherlands.
   [Dullaart, Robin P. F.] Univ Groningen, Univ Med Ctr Groningen, Dept Endocrinol, Groningen, Netherlands.
C3 University of Groningen; Universidad de Chile; University of Groningen;
   University of Groningen
RP Sotomayor, CG (corresponding author), Univ Med Ctr Groningen, Dept Internal Med, Div Nephrol, Hanzepl 1,POB 30-001, NL-9713 GZ Groningen, Netherlands.
EM c.g.sotomayor.campos@umcg.nl
RI Berger, Stefan/LFR-9164-2024; Rodrigo, Ramon/IYS-4056-2023; Bakker,
   Stephan/J-4023-2015; Sotomayor, Camilo G./AAH-9500-2019
OI Erazo, Marcia/0000-0002-0766-9503; Bakker, Stephan/0000-0003-3356-6791;
   Sotomayor, Camilo G./0000-0001-6835-6386; Sokooti Oskooei,
   Sara/0000-0003-0420-2497
FU Top Institute Food and Nutrition of the Netherlands [A-1003]; Comision
   Nacional de Investigacion Cientifica y Tecnologica [F 72190118]
FX This study was based on the TransplantLines Food and Nutrition Biobank
   and Cohort Study (TxL-FN), which was funded by the Top Institute Food
   and Nutrition of the Netherlands (grant A-1003). Dr. Sotomayor was
   supported by a doctorate studies grant from Comision Nacional de
   Investigacion Cientifica y Tecnologica (F 72190118). The study is
   registered at clinicaltrials.gOV under number NCT02811835.
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NR 61
TC 6
Z9 7
U1 0
U2 2
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0026-0495
EI 1532-8600
J9 METABOLISM
JI Metab.-Clin. Exp.
PD MAR
PY 2021
VL 116
AR 154465
DI 10.1016/j.metabol.2020.154465
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA QE0XN
UT WOS:000615931100014
PM 33316268
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Chang, E
   Kim, DH
   Yang, H
   Lee, DH
   Bae, SH
   Park, CY
AF Chang, Eugene
   Kim, Dae-Hee
   Yang, Hyekyung
   Lee, Da Hyun
   Bae, Soo Han
   Park, Cheol-Young
TI CB1 receptor blockade ameliorates hepatic fat infiltration and
   inflammation and increases Nrf2-AMPK pathway in a rat model of severely
   uncontrolled diabetes
SO PLOS ONE
LA English
DT Article
ID LIVER-DISEASE; NONALCOHOLIC STEATOHEPATITIS; ENDOCANNABINOID SYSTEM;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; OXIDATIVE STRESS; TISSUE
   INHIBITOR; ACTIVATION; STEATOSIS; EXPRESSION
AB Previous studies have shown that the CB1 receptor antagonist reverses steatohepatitis and its related features of metabolic syndrome, such as obesity and type 2 diabetes. However, the beneficial effects of CB1 receptor blockade on hepatic steatosis and inflammation have not been investigated independently of its effects on body weight and glycemic control. At 32 weeks of age, OLETF rats were administered with rimonabant (10 mg.kg(-1).day(-1)) by oral gavage for 6 weeks. No significant changes in body weight, OGTT, and serum glucose were observed in spite of rimonabant-decreased food intake. Moreover, there was a significant difference between initial and final body weight, regardless of rimonabant administration, indicating that OLETF rats were severely diabetic rats. Rimonabant administration significantly decreased serum liver enzyme levels such as ALT and AST, hepatic fat accumulation, lipid peroxidation, and cell death as demonstrated by the number of TUNEL-positive cells in severely uncontrolled diabetic OLETF rats. Significant decreases in hepatic gene expression of proinflammatory cytokines (CD11b, F4/80, MCP1, and TNF alpha), negative inflammatory mediators (SOCS1 and SOCS3), and fibrosis-related proteins (TGF beta, collagen 1, and TIMP1) were found in rimonabant-treated OLETF rats. Six-week administration of rimonabant significantly upregulated mRNA levels of CPT1 alpha and PPAR alpha related to beta-oxidation. Moreover, significant increases in Nrf2 gene expression and its downstream genes, NQO1, GSAT, HO-1, and TXNRD1 along with increased AMPK phosphorylation were noted in uncontrolled diabetic rats treated with rimonabant. The observed potent inhibitory effects of CB1 receptor blockade on hepatic fat infiltration and cellular death in severely uncontrolled diabetic rats indicate that CB1 receptor is a possible therapeutic target. Increased Nrf2 and AMPK phosphorylation may play a role in the mechanism of rimonabant action.
C1 [Chang, Eugene] Ewha Womans Univ, Dept Nutr Sci & Food Management, Seoul, South Korea.
   [Kim, Dae-Hee; Yang, Hyekyung] Sungkyunkwan Univ, Kangbuk Samsung Hosp, Med Res Inst, Sch Med, Seoul, South Korea.
   [Lee, Da Hyun; Bae, Soo Han] Yonsei Univ, Severance Biomed Sci Inst, Yonsei Biomed Res Inst, Coll Med, Seoul, South Korea.
   [Park, Cheol-Young] Sungkyunkwan Univ, Kangbuk Samsung Hosp, Div Endocrinol & Metab, Dept Internal Med,Sch Med, Seoul, South Korea.
C3 Ewha Womans University; Sungkyunkwan University (SKKU); Samsung Medical
   Center; Yonsei University; Yonsei University Health System; Sungkyunkwan
   University (SKKU); Samsung Medical Center
RP Bae, SH (corresponding author), Yonsei Univ, Severance Biomed Sci Inst, Yonsei Biomed Res Inst, Coll Med, Seoul, South Korea.; Park, CY (corresponding author), Sungkyunkwan Univ, Kangbuk Samsung Hosp, Div Endocrinol & Metab, Dept Internal Med,Sch Med, Seoul, South Korea.
EM soohanbae@yuhs.ac; cydoctor@chol.com
RI Lee, Hye/D-9081-2016; Park, Cheol-Young/C-6690-2018
OI Lee, Da Hyun/0000-0002-5412-6878; Park, Cheol-Young/0000-0002-9415-9965;
   Bae, Soo Han/0000-0002-8007-2906
FU Medical Research Funds from Kangbuk Samsung Hospital
FX This research was supported by the Medical Research Funds from Kangbuk
   Samsung Hospital to CYP. The funder had no role in study design, data
   collection and analysis, decision to publish, or preparation of the
   manuscript.
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NR 59
TC 32
Z9 33
U1 2
U2 8
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD OCT 26
PY 2018
VL 13
IS 10
AR e0206152
DI 10.1371/journal.pone.0206152
PG 17
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA GY3KA
UT WOS:000448448700027
PM 30365523
OA gold, Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Adinolfi, LE
   Rinaldi, L
   Guerrera, B
   Restivo, L
   Marrone, A
   Giordano, M
   Zampino, R
AF Adinolfi, Luigi Elio
   Rinaldi, Luca
   Guerrera, Barbara
   Restivo, Luciano
   Marrone, Aldo
   Giordano, Mauro
   Zampino, Rosa
TI NAFLD and NASH in HCV Infection: Prevalence and Significance in Hepatic
   and Extrahepatic Manifestations
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE HCV-associated NAFLD; insulin resistance; liver fibrosis; HCC; metabolic
   syndrome; diabetes; atherosclerosis
ID C VIRUS-INFECTION; FATTY LIVER-DISEASE; SUSTAINED VIROLOGICAL RESPONSE;
   HEPATOCELLULAR-CARCINOMA; FIBROSIS PROGRESSION; INSULIN-RESISTANCE;
   UNTREATED PATIENTS; DIABETES-MELLITUS; ANTIVIRAL THERAPY; CORE PROTEIN
AB The aim of this paper is to review and up to date the prevalence of hepatitis C virus (HCV)-associated non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) and their significance in both accelerating progression of HCV-related liver disease and development of HCV-associated extrahepatic diseases. The reported mean prevalence of HCV-related NAFLD was 55%, whereas NASH was reported in 4%-10% of cases. HCV genotype 3 directly induces fatty liver deposition, namely "viral steatosis" and it is associated with the highest prevalence and degree of severity, whereas, HCV non-3 genotype infection showed lower prevalence of steatosis, which is associated with metabolic factors and insulin resistance. The host's genetic background predisposes him or her to the development of steatosis. HCV's impairment of lipid and glucose metabolism causes fatty liver accumulation; this seems to be a viral strategy to optimize its life cycle. Irrespective of insulin resistance, HCV-associated NAFLD, in a degree-dependent manner, contributes towards accelerating the liver fibrosis progression and development of hepatocellular carcinoma by inducing liver inflammation and oxidative stress. Furthermore, NAFLD is associated with the presence of metabolic syndrome, type 2 diabetes, and atherosclerosis. In addition, HCV-related "metabolic steatosis" impairs the response rate to interferon-based treatment, whereas it seems that "viral steatosis" may harm the response rate to new oral direct antiviral agents. In conclusion, a high prevalence of NAFLD occurs in HCV infections, which is, at least in part, induced by the virus, and that NAFLD significantly impacts progression of the liver disease, therapeutic response, and some extrahepatic diseases.
C1 [Adinolfi, Luigi Elio; Rinaldi, Luca; Guerrera, Barbara; Restivo, Luciano; Marrone, Aldo; Giordano, Mauro; Zampino, Rosa] Univ Naples 2, Dept Med Surg Neurol Metab & Geriatr Sci, I-80100 Naples, Italy.
RP Adinolfi, LE (corresponding author), Univ Naples 2, Dept Med Surg Neurol Metab & Geriatr Sci, I-80100 Naples, Italy.
EM luigielio.adinolfi@unina2.it; lucarinaldi@hotmail.it;
   barbara.guerrera@alice.it; luciano.restivo@gmail.it;
   Aldo.marrone@unina2.it; mauro.giordano@unina2.it; rosa.zampino@unina2.it
RI Marrone, Aldo/AAH-3614-2020
OI GIORDANO, MAURO/0000-0001-8175-547X; MARRONE, Aldo/0000-0001-7329-4159
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NR 88
TC 90
Z9 98
U1 1
U2 23
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD JUN
PY 2016
VL 17
IS 6
AR 803
DI 10.3390/ijms17060803
PG 12
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA DP9EK
UT WOS:000378799300017
PM 27231906
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Gallos, ID
   Sivakumar, K
   Kilby, MD
   Coomarasamy, A
   Thangaratinam, S
   Vatish, M
AF Gallos, I. D.
   Sivakumar, K.
   Kilby, M. D.
   Coomarasamy, A.
   Thangaratinam, S.
   Vatish, M.
TI Pre-eclampsia is associated with, and preceded by,
   hypertriglyceridaemia: a meta-analysis
SO BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
LA English
DT Article
DE Meta-analysis; predictive marker; pre-eclampsia; systematic review;
   triglycerides
ID PLASMA-LIPID CONCENTRATIONS; LOW-DENSITY-LIPOPROTEIN; FREE FATTY-ACIDS;
   METABOLIC SYNDROME; OXIDATIVE STRESS; APOLIPOPROTEIN-E; WOMEN;
   PREGNANCY; RISK; HYPERTENSION
AB BackgroundElevated triglycerides are a feature of the metabolic syndrome, maternal obesity, maternal vasculitis (i.e. systemic lupus erythematosus) and diabetes mellitus. These conditions are all known risk factors for pre-eclampsia. Hypertriglyceridaemia therefore may be associated with pre-eclampsia and indeed this may precede the presence of overt disease.
   ObjectiveIn this study we determine the association between hypertriglyceridaemia and pre-eclampsia in pregnant women.
   Search strategyWe searched MEDLINE, EMBASE, Web of Science, Excerpta Medica Database, ISI Web of Knowledge, Cumulative Index to Nursing and Allied Health Literature, Cochrane Library from inception until June 2012 and reference lists of relevant studies.
   Selection criteriaTwo reviewers independently selected studies on pregnant women where triglycerides were measured and women were followed up until the development of pre-eclampsia or selected on the basis of presence of pre-eclampsia and compared with controls.
   Data collection and analysisWe collected and meta-analysed the weighted mean differences (WMDs) of triglyceride levels from individual studies using a random effects model.
   Main resultsWe found strong evidence from meta-analysis of 24 case-control studies (2720 women) that pre-eclampsia is associated with higher levels of serum triglycerides (WMD 0.78mmol/l, 95% confidence interval 0.6-0.96, P<0.00001). This finding is also confirmed in five cohort studies, that recruited 3147 women in the second trimester before the onset of pre-eclampsia, which proves that hypertriglyceridaemia precedes the onset of pre-eclampsia (WMD 0.24mmol/l, 95% confidence interval 0.13-0.34, P<0.0001).
   Author's conclusionsHypertriglyceridaemia is associated with and precedes the onset of pre-eclampsia. Further research should focus on defining the prognostic accuracy of this test to identify women at risk and the beneficial effect of triglyceride-lowering therapies in pregnancy.
C1 [Gallos, I. D.; Vatish, M.] Univ Oxford, Oxford Radcliffe Hosp NHS Trust, Nuffield Dept Obstet & Gynaecol, Oxford OX3 9DU, England.
   [Sivakumar, K.; Vatish, M.] Warwick Med Sch, Clin Sci Res Inst, Coventry, W Midlands, England.
   [Kilby, M. D.; Coomarasamy, A.] Univ Birmingham, Sch Clin & Expt Med Reprod Genes & Dev, Coll Med & Dent Sci, Birmingham, W Midlands, England.
   [Thangaratinam, S.] Queen Mary Univ London, Womens Hlth Res Unit, Ctr Primary Care & Publ Hlth, Barts & London Sch Med & Dent, London, England.
C3 Oxford University Hospitals NHS Foundation Trust; University of Oxford;
   University of Warwick; University of Birmingham; University of London;
   Queen Mary University London
RP Vatish, M (corresponding author), Univ Oxford, Oxford Radcliffe Hosp NHS Trust, Nuffield Dept Obstet & Gynaecol, Oxford OX3 9DU, England.
EM manu.vatish@obs-gyn.ox.ac.uk
RI FRCPI, Mark/AAW-9704-2020; vatish, manu/AAY-8750-2020; Thangaratinam,
   Shakila/AAP-3724-2021; N, Kavitha/P-9554-2016
OI Thangaratinam, Shakila/0000-0002-4254-460X; Gallos,
   Ioannis/0000-0002-2766-358X; vatish, manu/0000-0002-6012-2574; Kilby,
   Mark/0000-0001-9987-4223
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NR 52
TC 99
Z9 111
U1 0
U2 11
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1470-0328
EI 1471-0528
J9 BJOG-INT J OBSTET GY
JI BJOG
PD OCT
PY 2013
VL 120
IS 11
BP 1321
EP 1332
DI 10.1111/1471-0528.12375
PG 12
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA 216RU
UT WOS:000324302500003
PM 23859707
OA Bronze
DA 2025-06-11
ER

PT J
AU Abou-Khalil, NS
   Ali, MF
   Ali, MM
   Ibrahim, A
AF Abou-Khalil, Nasser S.
   Ali, Marwa F.
   Ali, Magda M.
   Ibrahim, Ahmed
TI Surgical castration versus chemical castration in donkeys: response of
   stress, lipid profile and redox potential biomarkers
SO BMC VETERINARY RESEARCH
LA English
DT Article
DE Surgical castration; Chemical castration; Physiology; Stress; Lipid
   profile; Oxidative stress
ID SINGLE INTRATESTICULAR INJECTION; ACUTE CORTISOL RESPONSE;
   CALCIUM-CHLORIDE; OXIDATIVE STRESS; NONSURGICAL STERILIZATION;
   ENDOGENOUS TESTOSTERONE; BEHAVIORAL-RESPONSES; GROWTH-PERFORMANCE;
   METABOLIC SYNDROME; LOCAL-ANESTHESIA
AB Background Castration is a husbandry practice raising important questions on the welfare and physiological status of farm animals. Searching for effective castration methods that minimally compromise the body physiology is worthy of attention. Therefore, this study aimed to evaluate the differential response of biological systems in donkeys to surgical castration versus the chemical one by CaCl(2)with special emphasis on stress, lipid profile, and oxidative stress biomarkers. Donkeys were divided randomly and equally into two groups; the chemical (Ch) and surgical (S) groups (n = 6). The Ch group was chemically castrated by intratesticular injection of 20% CaCl(2)dissolved in absolute ethanol. Blood samples were collected prior to castration and at 15, 30, 45, and 60 days after the beginning of experiment. Results Surprisingly, the Ch group at the end of the experiment was characterized by significantly higher cortisol level compared to the S group. TC and LDL-C levels in the S group significantly decreased at day 45, while TG levels significantly increased at days 45 and 60 in comparison with day 0. HDL-C levels at days 30 and 60 in the Ch group significantly increased in comparison with day 0. At day 30 post-castration, HDL-C was significantly higher and LDL-C was significantly lower in the Ch group than the S group. A significant elevation in TC and LDL-C was observed at day 45 and in HDL-C at the end of experimental duration in the Ch group when compared with the S group. TPX level was significantly lower and TAC was significantly higher in the Ch group at day 45 than the S group. Conclusion Surgical castration evoked less stress and minor changes in lipid profile and oxidant/antioxidant balance relative to chemical castration by intratesticular 20% CaCl(2)dissolved in absolute ethanol.
C1 [Abou-Khalil, Nasser S.] Assiut Univ, Fac Med, Dept Med Physiol, Assiut 71526, Egypt.
   [Ali, Marwa F.] Assiut Univ, Fac Vet Med, Dept Vet Pathol & Clin Pathol, Assiut 71526, Egypt.
   [Ali, Magda M.] Assiut Univ, Fac Vet Med, Dept Surg Anesthesiol & Radiol, Assiut 71526, Egypt.
   [Ibrahim, Ahmed] Assiut Univ, Vet Teaching Hosp, Fac Vet Med, Assiut 71526, Egypt.
C3 Egyptian Knowledge Bank (EKB); Assiut University; Egyptian Knowledge
   Bank (EKB); Assiut University; Egyptian Knowledge Bank (EKB); Assiut
   University; Egyptian Knowledge Bank (EKB); Assiut University
RP Ibrahim, A (corresponding author), Assiut Univ, Vet Teaching Hosp, Fac Vet Med, Assiut 71526, Egypt.
EM elgrah38@gmail.com
RI Ibrahim, Ahmed/AAX-1051-2020; Abou khalil, Nasser/JRX-8776-2023; Ali,
   Marwa/AFO-1407-2022
OI Ibrahim, Ahmed/0000-0002-9753-5006
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NR 81
TC 12
Z9 12
U1 0
U2 8
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1746-6148
J9 BMC VET RES
JI BMC Vet. Res.
PD AUG 26
PY 2020
VL 16
IS 1
AR 310
DI 10.1186/s12917-020-02530-0
PG 10
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA NL1CT
UT WOS:000567162600002
PM 32847551
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Prior, SL
   Gable, DR
   Cooper, JA
   Bain, SC
   Hurel, SJ
   Humphries, SE
   Stephens, JW
AF Prior, Sarah L.
   Gable, David R.
   Cooper, Jackie A.
   Bain, Stephen C.
   Hurel, Steven J.
   Humphries, Steve E.
   Stephens, Jeffrey W.
TI Association between the adiponectin promoter rs266729 gene
   variant and oxidative stress in patients with diabetes mellitus
SO EUROPEAN HEART JOURNAL
LA English
DT Article
DE Adiponectin; Oxidative stress; rs266729; Gene; Coronary heart disease;
   Diabetes
ID CORONARY-HEART-DISEASE; ADIPOSE-SPECIFIC PROTEIN; METABOLIC SYNDROME;
   OXIDATIVE/NITRATIVE STRESS; UNCOUPLING PROTEIN-2; SUSCEPTIBILITY LOCUS;
   INSULIN-RESISTANCE; PLASMA; RISK; HYPOADIPONECTINEMIA
AB Low levels of adiponectin are associated with type 2 diabetes and coronary heart disease (CHD). Recent evidence also suggests that low levels of adiponectin are associated with increased oxidative stress. Our aim was to examine the association between the rs266729 promoter gene variant (-11377C > G) and plasma markers of oxidative stress in diabetes subjects.
   Seven hundred and sixty-seven Caucasian subjects with diabetes were successfully genotyped (CC/CG/GG). Genotype data were analysed in relation to plasma total antioxidant status (TAOS) and Oxidized-LDL (Ox-LDL). Plasma adiponectin measurements were available in 206 samples. There was a significant association between genotype and plasma TAOS (CC: 42.1 +/- 13.4% vs. CG: 42.0 +/- 12.0% vs. GG: 47.9 +/- 12.0%, P = 0.02; for CC/CG vs. GG, P = 0.006). With respect to Ox-LDL, CC subjects had 8% higher plasma Ox-LDL compared with CG/GG [CC vs. CG vs. GG: 48.5 (36.3-60.2) U/L vs. 44.8 (35.6-54.1) U/L vs. 44.9 (41.2-49.1) U/L, for CC vs. CG/GG P = 0.03]. For plasma adiponectin, GG subjects had the highest levels [CC vs. CG vs. GG: 8.18 (5.69-15.38) mu g/mL vs. 7.12 (5.34-12.97) mu g/mL vs. 11.84 (6.98-25.25) mu g/mL, P = 0.09; for CC/CG vs. GG, P = 0.05].
   This study shows an association between a promoter variant in the adiponectin gene and plasma markers of oxidative stress. In line with previous studies, this work supports an antioxidant role for adiponectin which may explain its cardioprotective effect. Further prospective study is necessary to explore the effect of this gene variant in diabetes in relation to CHD risk and oxidative stress.
C1 [Prior, Sarah L.; Bain, Stephen C.; Stephens, Jeffrey W.] Swansea Univ, Diabet Res Grp, Inst Life Sci, Swansea SA2 8PP, W Glam, Wales.
   [Gable, David R.; Cooper, Jackie A.; Humphries, Steve E.] Royal Free & Univ Coll Med Sch, Ctr Cardiovasc Genet, British Heart Fdn Labs, London WC1E 6JF, England.
   [Hurel, Steven J.] UCL Hosp, Dept Endocrinol & Diabet, London W1T 3AA, England.
C3 Swansea University; University of London; University College London;
   University of London; University College London; University College
   London Hospitals NHS Foundation Trust
RP Stephens, JW (corresponding author), Swansea Univ, Diabet Res Grp, Inst Life Sci, Singleton Pk, Swansea SA2 8PP, W Glam, Wales.
EM j.w.stephens@swansea.ac.uk
RI Humphries, Stephen/C-5075-2008
OI Humphries, Stephen E/0000-0002-8221-6547
FU Diabetes UK [BDA: RD01/0001357]; UDACS; British Heart Foundation [RG2005
   014]
FX Diabetes UK (BDA: RD01/0001357 to J.W.S.) and the creation of UDACS, the
   British Heart Foundation (RG2005 014 to S. E. H.).
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NR 45
TC 19
Z9 19
U1 0
U2 3
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0195-668X
EI 1522-9645
J9 EUR HEART J
JI Eur. Heart J.
PD MAY
PY 2009
VL 30
IS 10
BP 1263
EP 1269
DI 10.1093/eurheartj/ehp090
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 446IL
UT WOS:000266115200019
PM 19324915
OA Bronze
DA 2025-06-11
ER

PT J
AU Ghorbani, Z
   Shoaibinobarian, N
   Zamani, E
   Salari, A
   Mahdavi-Roshan, M
   Porteghali, P
   Ahmadnia, Z
AF Ghorbani, Zeinab
   Shoaibinobarian, Nargeskhatoon
   Zamani, Ehsan
   Salari, Arsalan
   Mahdavi-Roshan, Marjan
   Porteghali, Parham
   Ahmadnia, Zahra
TI Supplementing the standard diet with brown rice bran powder might
   effectively improve the metabolic syndrome characteristics and
   antioxidant status: an open label randomized controlled trial
SO FOOD & FUNCTION
LA English
DT Article
ID HIGH-FAT; CARDIOVASCULAR-DISEASE; ENZYMATIC EXTRACT; OXIDATIVE STRESS;
   CHOLESTEROL; ATHEROSCLEROSIS; OVERWEIGHT; MORTALITY; MECHANISM; FIBER
AB Purpose: This study explores the impact of brown rice bran powder (BRBP), known for its beneficial components, such as dietary fiber and gamma-oryzanol, on individuals suffering from metabolic syndrome (MetS). Subjects/Methods: In this eight-week open-label controlled trial, fifty participants with MetS were randomly assigned to either a control group, which received a standard diet (SDiet), or an intervention group, which incorporated 15 grams of BRBP daily into their diet. Demographic, anthropometric and clinical data were collected, and blood samples were taken to assess metabolic factors and antioxidant enzyme activities. Additionally, the participants completed the gastrointestinal symptom rating scale questionnaire. Results: Analysis of covariance controlled for the baseline levels and medication consumptions revealed that postthis trial, compared to the controls, patients who received BRBP showed significant reductions in BMI (P-value = 0.001; effect size (ES): -1.13), waist circumference (P-value < 0.001; ES: -1.28), total-cholesterol (P-value = 0.028; ES: -0.74), LDL-cholesterol (P-value = 0.002; ES: -0.86), blood sugar (P-value = 0.013; ES: -0.82), as well as triglyceride glucose (TyG)-BMI index (as a marker of insulin resistance) (P-value < 0.001; ES: -1.35). Further, BRBP resulted in significant improvements in antioxidant enzyme activities, including glutathione peroxidase (P-value = 0.010; ES: 0.86), superoxide dismutase serum activities (P-value = 0.021; ES: 0.78), and constipation rate (P-value = 0.018; ES: -0.85) compared to SDiet alone. However, no significant changes were found regarding levels of triglyceride, HDL-cholesterol, glutathione, catalase and blood pressure after the trial. Conclusion: The findings of this trial support the weight-reducing, hypocholestrolemic, anti-hyperglycemic, and antioxidative effects of adding BRBP to SDiet that is prescribed for MetS patients.
C1 [Ghorbani, Zeinab; Salari, Arsalan; Mahdavi-Roshan, Marjan; Porteghali, Parham; Ahmadnia, Zahra] Guilan Univ Med Sci, Heshmat Hosp, Cardiovasc Dis Res Ctr, Dept Cardiol,Sch Med, Rasht, Iran.
   [Ghorbani, Zeinab; Mahdavi-Roshan, Marjan] Guilan Univ Med Sci, Sch Med, Dept Clin Nutr, Rasht, Iran.
   [Shoaibinobarian, Nargeskhatoon] Islamic Azad Univ, Sch Med Sci & Technol, Dept Nutr, Sci & Res Branch, Tehran, Iran.
   [Zamani, Ehsan] Guilan Univ Med Sci, Sch Pharm, Dept Pharmacol & Toxicol, Rasht, Iran.
   [Porteghali, Parham] Guilan Univ Med Sci, Dept Internal Med, Rasht, Iran.
C3 Guilan University of Medical Sciences; Guilan University of Medical
   Sciences; Islamic Azad University; Guilan University of Medical
   Sciences; Guilan University of Medical Sciences
RP Mahdavi-Roshan, M (corresponding author), Guilan Univ Med Sci, Heshmat Hosp, Cardiovasc Dis Res Ctr, Dept Cardiol,Sch Med, Rasht, Iran.; Mahdavi-Roshan, M (corresponding author), Guilan Univ Med Sci, Sch Med, Dept Clin Nutr, Rasht, Iran.
EM marjanmahdavi60@gmail.com
RI Porteghali, Parham/AAK-8912-2021; Salari, Arsalan/D-2855-2019;
   Mahdavi-Roshan, Marjan/H-1444-2017; Zamani, Ehsan/D-7674-2018; ghorbani,
   zeinab/AAF-5343-2021
OI Mahdavi-Roshan, Marjan/0000-0002-2645-6714
FU Guilan University of Medical Sciences [71213]; Guilan University of
   medical sciences, Rasht, Iran
FX This study was financially supported by Guilan University of medical
   sciences, Rasht, Iran (registered with research number = 71213). The
   authors would like to thank the Giltaz Company which donated the powders
   with no conflict of interest. The donating company was not involved in
   study design, acquiring data, statistical analysis, results
   interpretation, or publication. None of the authors had any affiliation
   to this company. We also extend our gratitude to the patients who
   participated in the study.
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NR 58
TC 1
Z9 1
U1 3
U2 3
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PD JAN 20
PY 2025
VL 16
IS 2
BP 750
EP 762
DI 10.1039/d4fo03642e
EA DEC 2024
PG 13
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA S6Y8W
UT WOS:001391628800001
PM 39775811
DA 2025-06-11
ER

PT J
AU Kornicka, K
   Smieszek, A
   Wegrzyn, AS
   Röcken, M
   Marycz, K
AF Kornicka, Katarzyna
   Smieszek, Agnieszka
   Wegrzyn, Agnieszka Slawomira
   Roecken, Michael
   Marycz, Krzysztof
TI Immunomodulatory Properties of Adipose-Derived Stem Cells Treated with
   5-Azacytydine and Resveratrol on Peripheral Blood Mononuclear Cells and
   Macrophages in Metabolic Syndrome Animals
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Article
DE adipose-derived stem cells; mesenchymal stem cells; inflammation;
   autophagy; immunomodulatory effects
ID REGULATORY T-CELLS; OXIDATIVE STRESS; TISSUE; INFLAMMATION; AUTOPHAGY;
   CYTOKINE; OBESE; SENESCENCE; EXPRESSION; RESISTANT
AB Endocrine disorders, including equine metabolic syndrome (EMS), are a serious issue in veterinary medicine and horse breeding. Furthermore, EMS was shown to affect the cytophysiological properties of adipose-derived stem cells, reducing their therapeutic potential. However, it was shown that those cells can be rejuvenated while using a combination of two chemicals: 5-azacytydine (AZA) and resveratrol (RES). In the present study, we decided to evaluate the immunomodulatory properties of AZA/RES-treated adipose-derived stem cells (ASC) isolated from EMS horses (ASC(EMS)). Thus, we co-cultured ASC with peripheral blood mononuclear cells (PBMC) and RAW264.7 macrophages. Most attention was placed on regulatory T lymphocytes (T-REG), as well as the messenger RNA (mRNA) and protein levels of several cytokines (tumor necrosis factor alpha (TNF-alpha), interleukin (IL)-6, IL-10, and IL-1 beta). Moreover, we also investigated the expression of genes related to auto- and mitophagy in both PBMCs and ASCs. PBMCs were obtained from healthy and EMS-suffering individuals and were co-cultured with ASCs that were isolated from healthy and EMS horses cultured in control conditions and with AZA/RES. We discovered that cells treated with AZA/RES increase the T-REG number while co-cultured with PBMCs. Moreover, the co-culture of PBMCs with AZA/RES-treated ASC(EMS) induced mitophagy in PBMCs. Furthermore, ASC(EMS) pre-treated with AZA/RES displayed anti-inflammatory properties, as decreased levels of TNF-alpha, nitric oxide (NO), and IL-6 were observed in those cells in comparison with their untreated counterparts in the co-culture with RAW264.7 macrophages. In summary, we demonstrated that ASC(EMS) treated with AZA/RES displayed increased anti-inflammatory properties, and was able to regulate and activate the T-REG-related anti-inflammatory response.
C1 [Kornicka, Katarzyna; Smieszek, Agnieszka; Marycz, Krzysztof] Univ Environm & Life Sci, Fac Biol & Anim Sci, Dept Expt Biol, PL-50375 Wroclaw, Poland.
   [Wegrzyn, Agnieszka Slawomira] PORT Polish Ctr Technol Dev, PL-54066 Wroclaw, Poland.
   [Roecken, Michael; Marycz, Krzysztof] Justus Liebig Univ, Fac Vet Med, Equine Clin Equine Surg, D-35392 Giessen, Germany.
C3 Wroclaw University of Environmental & Life Sciences; Justus Liebig
   University Giessen
RP Marycz, K (corresponding author), Univ Environm & Life Sci, Fac Biol & Anim Sci, Dept Expt Biol, PL-50375 Wroclaw, Poland.; Marycz, K (corresponding author), Justus Liebig Univ, Fac Vet Med, Equine Clin Equine Surg, D-35392 Giessen, Germany.
EM kornicka.katarzyna@gmail.com; smieszek.agnieszka@gmail.com;
   agnieszka.wegrzyn@eitplus.pl; Michael.Roecken@vetmed.uni-giessen.de;
   krzysztofmarycz@interia.pl
RI ; Smieszek, Agnieszka/A-4887-2017
OI Marycz, Krzysztof/0000-0003-3676-796X; Smieszek,
   Agnieszka/0000-0002-7314-9821; Wegrzyn, Agnieszka
   Slawomira/0000-0001-9502-9911
FU National Science Centre in Poland [2016/21/B/NZ7/01111]; Wroclaw Centre
   of Biotechnology, programme the Leading National Research Centre (KNOW)
FX This project is financed in the framework of grant entitled "Modulation
   mitochondrial metabolism and dynamics and targeting DNA methylation of
   adipose derived mesenchymal stromal stem cell (ASC) using RES and
   5-azacytydin as a therapeutic strategy in the course of EMS." (grant no.
   2016/21/B/NZ7/01111) financed by The National Science Centre in Poland.
   The publication is supported by Wroclaw Centre of Biotechnology,
   programme the Leading National Research Centre (KNOW) for years
   2014-2018.
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NR 44
TC 23
Z9 25
U1 0
U2 8
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD NOV
PY 2018
VL 7
IS 11
AR 383
DI 10.3390/jcm7110383
PG 18
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA HB8CK
UT WOS:000451311900006
PM 30356025
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Malan, L
   Schutte, CE
   Alkerwi, A
   Stranges, S
   Malan, NT
AF Malan, Leone
   Schutte, Christiaan E.
   Alkerwi, Ala'a
   Stranges, Saverio
   Malan, Nicolaas T.
TI Hypothalamic-pituitary-adrenal-axis dysregulation and double product
   increases potentiate ischemic heart disease risk in a Black male cohort:
   the SABPA study
SO HYPERTENSION RESEARCH
LA English
DT Article
DE Africans; double product; hypothalamic-pituitary-adrenal-axis;
   myocardial ischemia
ID LEFT-VENTRICULAR HYPERTROPHY; AMBULATORY BLOOD-PRESSURE;
   VASCULAR-DISEASE; PSYCHOLOGICAL DISTRESS; DEPRESSIVE SYMPTOMS; METABOLIC
   SYNDROME; CORTISOL RESPONSE; AFRICANS; HYPERTENSION; POPULATION
AB Emotional distress has been associated with a poorer prognosis in myocardial infarction patients. Elevated adrenocorticotrophic hormone (ACTH), lower cortisol, dehydroepiandrosterone sulfate (DHEAS) and cortisol: DHEAS, as measures of emotional distress, might correlate with silent myocardial ischemia (SMI) and workload. Thus, we assessed the relationship between emotional distress, SMI and double product (systolic blood pressure (SBP) x heart rate). Cross-sectional South African biethnic single-set cohorts (N= 378), aged 44.7 +/- 9.52 years, were investigated. Depressive symptoms (Patient Health Questionnaire-9), anthropometric, fasting blood, 24-h double product and 24-h 2-lead electrocardiogram (ST-segment depression) values were obtained. Blacks, mostly men, had increased depressive symptoms, hyperglycemia, SMI, double product, SBP hypertension and ACTH but lower cortisol, DHEAS and cortisol: DHEAS than their White counterparts. Black men had the highest combined SBP hypertension and below-median cortisol prevalence, 38%, compared with 5.9-13.8% in the other groups. Their SMI was associated with ACTH and cortisol: DHEAS (adj. R-2 0.29; beta 0.27-0.31 (0.12-0.64); P <= 0.05), double product (adj. R-2 0.29; beta 0.38 (0.18-0.57); P = 0.050) and SBP hypertension (area under the curve: 0.68 (95% CI: 0.56, 0.80); P= 0.042; sensitivity/specificity 49/85%). Double product was positively associated with central obesity in all sex groups and with cortisol in the Black men (P<0.05). A dysregulated hypothalamic-pituitary-adrenal-axis (HPAA) showed signs of a hyporesponsive adrenal cortex, suggesting chronic emotional stress in the Black male cohort. In this cohort, HPAA dysregulation and compensatory increases in double product occur as a potential defense mechanism to alleviate perfusion deficits, thereby potentiating ischemic heart disease risk.
C1 [Malan, Leone; Schutte, Christiaan E.; Malan, Nicolaas T.] North West Univ, Sch Physiol Nutr & Consumer Sci, HART, Private Bag X6001, ZA-2520 Potchefstroom, South Africa.
   [Alkerwi, Ala'a; Stranges, Saverio] Luxembourg Inst Hlth, Dept Populat Hlth, Epidemiol & Publ Hlth Res Unit, Strassen, Luxembourg.
   [Stranges, Saverio] Western Univ, Schulich Sch Med & Dent, Dept Epidemiol & Biostat, London, ON, Canada.
C3 North West University - South Africa; Luxembourg Institute of Health;
   Western University (University of Western Ontario)
RP Malan, L (corresponding author), North West Univ, Sch Physiol Nutr & Consumer Sci, HART, Private Bag X6001, ZA-2520 Potchefstroom, South Africa.
EM leone.malan@nwu.ac.za
RI Alkerwi, Ala'a/M-3435-2014; Stranges, Saverio/F-3273-2010; Malan,
   Leone/Q-8187-2019; Malan, Leone/D-7203-2014
OI Alkerwi, Ala'a/0000-0002-7448-3936; Stranges,
   Saverio/0000-0001-5226-8373; Malan, Leone/0000-0003-3187-2410
FU National Research Foundation; Medical Research Council; North-West
   University; Potchefstroom Campus; North-West Province; ROCHE Diagnostics
   South Africa; Metabolic Syndrome Institute, France
FX We gratefully acknowledge the voluntary collaboration of the
   participants. The SABPA study would not have been possible without the
   valuable contributions of the coinvestigators and technical staff. The
   present study was partially funded by the National Research Foundation,
   Medical Research Council, North-West University, Potchefstroom Campus,
   North-West Province, ROCHE Diagnostics South Africa and the Metabolic
   Syndrome Institute, France.
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NR 42
TC 13
Z9 13
U1 0
U2 1
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0916-9636
EI 1348-4214
J9 HYPERTENS RES
JI Hypertens. Res.
PD JUN
PY 2017
VL 40
IS 6
BP 590
EP 597
DI 10.1038/hr.2017.5
PG 8
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA EW7EE
UT WOS:000402671800012
PM 28179626
DA 2025-06-11
ER

PT J
AU Yang, Z
   Roth, K
   Agarwal, M
   Liu, WQ
   Petriello, MC
AF Yang, Zhao
   Roth, Katherine
   Agarwal, Manisha
   Liu, Wanqing
   Petriello, Michael C.
TI The transcription factors CREBH, PPARa, and FOXO1 as critical hepatic
   mediators of diet-induced metabolic dysregulation
SO JOURNAL OF NUTRITIONAL BIOCHEMISTRY
LA English
DT Article
DE CREBH; PPAR; FOXO1; Metabolic syndrome; diet induced obesity; NAFLD
ID ACTIVATED RECEPTOR-ALPHA; FATTY LIVER-DISEASE; ELEMENT-BINDING PROTEIN;
   ENDOPLASMIC-RETICULUM STRESS; INDUCED NONALCOHOLIC STEATOHEPATITIS;
   RETINOID-X-RECEPTOR; INSULIN SENSITIVITY; LIPID-METABOLISM;
   GENE-EXPRESSION; GREEN TEA
AB The liver is a critical mediator of lipid and/or glucose homeostasis and is a primary organ involved in dynamic changes during feeding and fasting. Additionally, hepatic-centric pathways are prone to dysregulation during pathophysiological states including metabolic syndrome (MetS) and non-alcoholic fatty liver disease. Omics platforms and GWAS have elucidated genes related to increased risk of developing MetS and related disorders, but mutations in these metabolism-related genes are rare and cannot fully explain the increasing prevalence of MetS-related pathologies worldwide. Complex interactions between diet, lifestyle, environmental factors, and genetic predisposition jointly determine inter-individual variability of disease risk. Given the complexity of these interactions, researchers have focused on master regulators of metabolic responses incorporating and mediating the impact of multiple environmental cues. Transcription factors are DNA binding, terminal executors of signaling pathways that modulate the cellular responses to complex metabolic stimuli and are related to the control of hepatic lipid and glucose homeostasis. Among numerous hepatic transcription factors involved in regulating metabolism, three emerge as key players in transducing nutrient sensing, which are dysregulated in MetS-related perturbations in both clinical and preclinical studies: cAMP Responsive Element Binding Protein 3 Like 3 (CREB3L3), Peroxisome Proliferator Activated Receptor Alpha (PPAR), and Forkhead Box O1 (FOXO1). Additionally, these three transcription factors appear to be amenable to dietary and/or nutrient-based therapies, being potential targets of nutritional therapy. In this review we aim to describe the activation, regulation, and impact of these transcription factors in the context of metabolic homeostasis. We also summarize their perspectives in MetS and nutritional therapies. (c) 2021 Elsevier Inc. All rights reserved.
C1 [Yang, Zhao; Roth, Katherine; Petriello, Michael C.] Wayne State Univ, Inst Environm Hlth Sci IEHS, Detroit, MI USA.
   [Agarwal, Manisha; Liu, Wanqing; Petriello, Michael C.] Wayne State Univ, Sch Med, Dept Pharmacol, Detroit, MI 48201 USA.
   [Liu, Wanqing] Wayne State Univ, Coll Pharm, Dept Pharmaceut Sci, Detroit, MI USA.
C3 Wayne State University; Wayne State University; Wayne State University
RP Petriello, MC (corresponding author), 6135 Woodward Ave,IBio 2128, Detroit, MI 48202 USA.
EM michael.petriello@wayne.edu
OI Yang, Zhao/0000-0002-4133-3130; Roth, Katherine/0000-0003-4826-3400
FU National Institute of En-vironmental Health Sciences [P30 ES020957,
   R00ES028734]; National Institute of Diabetes and Digestive and Kidney at
   the National Institutes of Health [R01DK106540]; Of-fice of the Vice
   President for Research at Wayne State University; National Institute of
   Environmental Health Sciences [P30ES020957, R00ES028734] Funding Source:
   NIH RePORTER
FX This work was supported by the National Institute of En-vironmental
   Health Sciences [P30 ES020957, R00ES028734] and the National Institute
   of Diabetes and Digestive and Kidney [R01DK106540] at the National
   Institutes of Health and the Of-fice of the Vice President for Research
   at Wayne State University. The content is solely the responsibility of
   the authors and does not necessarily represent the official views of the
   National Institutes of Health.
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NR 225
TC 26
Z9 31
U1 1
U2 18
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0955-2863
EI 1873-4847
J9 J NUTR BIOCHEM
JI J. Nutr. Biochem.
PD SEP
PY 2021
VL 95
AR 108633
DI 10.1016/j.jnutbio.2021.108633
EA APR 2021
PG 14
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA TX3DB
UT WOS:000682968500002
PM 33789150
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Nowicki, M
   Kosacka, J
   Serke, H
   Blüher, M
   Spanel-Borowski, K
AF Nowicki, Marcin
   Kosacka, Joanna
   Serke, Heike
   Blueher, Matthias
   Spanel-Borowski, Katharina
TI Altered sciatic nerve fiber morphology and endoneural microvessels in
   mouse models relevant for obesity, peripheral diabetic polyneuropathy,
   and the metabolic syndrome
SO JOURNAL OF NEUROSCIENCE RESEARCH
LA English
DT Article
DE sciatic nerve; endoneural microvessels; obese mouse models; peripheral
   diabetic neuropathy
ID DENSITY-LIPOPROTEIN RECEPTOR; TOLL-LIKE RECEPTOR-4; ENDOTHELIAL
   DYSFUNCTION; CARDIOVASCULAR-DISEASE; OB/OB MOUSE; DB/DB MICE;
   NEUROPATHY; LEPTIN; ATHEROSCLEROSIS; MECHANISMS
AB The morphology of sciatic nerves from leptin-deficient ob/ob mice and leptin receptor-deficient db/db mice, both models for obesity, peripheral diabetic neuropathy, and the metabolic syndrome, has yet to be examined for changes in nerve fibers and in endoneural microvessels. Sciatic nerves from three groups of 4-month-old mice (WT C57BL6, ob/ob, and db/db) were investigated. In ultrathin sections, the thickness of myelin sheaths was significantly reduced in small, medium-sized, and large axons of db/db mice compared with WT mice. In ob/ob mice, only large fibers showed a decrease in myelin sheath thickness. The number of nonmyelinated nerve fibers was lower in ob/ob mice than in the db/db group. A thickened basal lamina of Schwann cells occurred in the ob/ob group only. In contrast, the basement membrane of endoneural microvessels was thickened in both obese groups. For this reason, laminin expression in Western blot analysis was lower in the db/db group than in the ob/ob one. Endoneural microvessels, which had been injected with fluorescein isothiocyanate, depicted signs of vasodilatation in the ob/ob and vasoconstriction in db/db mice. Endoneural vessels displayed two receptors of oxLDL. LOX-1 was strongly expressed in db/db mice, whereas TLR4 was at its maximum in the ob/ob group. We conclude that changes in nerve fibers and in endoneural microvessels are present in sciatic nerve of both mouse models of type 2 diabetes. Upregulation of oxLDL-dependent receptors in endoneural microvessels might be connected to different degrees of oxidative stress in severe diabetic db/db mice and in the mild diabetic ob/ob group. (c) 2011 Wiley Periodicals, Inc.
C1 [Nowicki, Marcin; Serke, Heike; Spanel-Borowski, Katharina] Univ Leipzig, Inst Anat, D-04103 Leipzig, Germany.
   [Kosacka, Joanna; Blueher, Matthias] Univ Leipzig, Dept Med, D-04103 Leipzig, Germany.
   [Blueher, Matthias; Spanel-Borowski, Katharina] IZKF Leipzig, Leipzig, Germany.
C3 Leipzig University; Leipzig University
RP Nowicki, M (corresponding author), Univ Leipzig, Inst Anat, Liebigstr 13, D-04103 Leipzig, Germany.
EM marcin.nowicki@medizin.uni-leipzig.de
FU Deutsche Forschungsgemeinschaft Clinical Research Group ''Atherobesity''
   [KFO 152, BL 833/1-1]; Interdisciplinary Center of Clinical Research
   (IZKF) Leipzig at the Faculty of Medicine of the University of Leipzig
   [B24]
FX Contract grant sponsor: Deutsche Forschungsgemeinschaft Clinical
   Research Group ''Atherobesity'' KFO 152; Contract grant number: BL
   833/1-1 (to M.B.); Contract grant sponsor: Interdisciplinary Center of
   Clinical Research (IZKF) Leipzig at the Faculty of Medicine of the
   University of Leipzig; Contract grant number: B24 (to K.S.-B., M.B.).
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NR 34
TC 48
Z9 49
U1 0
U2 5
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0360-4012
J9 J NEUROSCI RES
JI J. Neurosci. Res.
PD JAN
PY 2012
VL 90
IS 1
BP 122
EP 131
DI 10.1002/jnr.22728
PG 10
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 860LZ
UT WOS:000297951100011
PM 21919033
DA 2025-06-11
ER

PT J
AU Takahashi, MM
   de Oliveira, EP
   de Carvalho, ALR
   Dantas, LAD
   Burini, FHP
   Portero-McLellan, KC
   Burini, RC
AF Takahashi, Mauro Massao
   de Oliveira, Erick Prado
   Rochitti de Carvalho, Ana Lygia
   de Souza Dantas, Lidiane Affonso
   Paganini Burini, Franz Homero
   Portero-McLellan, Katia Cristina
   Burini, Roberto Carlos
TI Metabolic syndrome and dietary components are associated with coronary
   artery disease risk score in free-living adults: a cross-sectional study
SO DIABETOLOGY & METABOLIC SYNDROME
LA English
DT Article
ID SERUM URIC-ACID; HEART-DISEASE; CARDIOVASCULAR-DISEASE; FIBER INTAKE;
   OXIDATIVE STRESS; LONG-TERM; MORTALITY; MEN; HEALTH; FAT
AB Background: Coronary artery disease (CAD) is among the main causes of death in developed countries, and diet and lifestyle can influence CAD incidence.
   Objective: To evaluate the association of coronary artery disease risk score with dietary, anthropometric and biochemical components in adults clinically selected for a lifestyle modification program.
   Methods: 362 adults (96 men, 266 women, 53.9 +/- 9.4 years) fulfilled the inclusion criteria by presenting all the required data. The Framingham score was calculated and the IV Brazilian Guideline on Dyslipidemia and Prevention of Atherosclerosis was adopted for classification of the CAD risks. Anthropometric assessments included waist circumference (WC), body fat and calculated BMI (kg/m(2)) and muscle-mass index (MMI kg/m(2)). Dietary intake was estimated through 24 h dietary recall. Fasting blood was used for biochemical analysis. Metabolic Syndrome (MS) was diagnosed using NCEP-ATPIII (2001) criteria. Logistic regression was used to determine the odds of CAD risks according to the altered components of MS, dietary, anthropometric, and biochemical components.
   Results: For a sample with a BMI 28.5 +/- 5.0 kg/m(2) the association with lower risk (<10% CAD) were lower age (<60 years old), and plasma values of uric acid. The presence of MS within low, intermediary, and high CAD risk categories was 30.8%, 55.5%, and 69.8%, respectively. The independent risk factors associated with CAD risk score was MS and uric acid, and the protective factors were recommended intake of saturated fat and fiber and muscle mass index.
   Conclusion: Recommended intake of saturated fat and dietary fiber, together with proper muscle mass, are inversely associated with CAD risk score. On the other hand, the presence of MS and high plasma uric acid are associated with CAD risk score.
C1 [Takahashi, Mauro Massao; de Oliveira, Erick Prado; Rochitti de Carvalho, Ana Lygia; de Souza Dantas, Lidiane Affonso; Paganini Burini, Franz Homero; Portero-McLellan, Katia Cristina; Burini, Roberto Carlos] UNESP Sch Med, Dept Publ Hlth, Ctr Nutr & Phys Exercise Metab, Botucatu, SP, Brazil.
   [de Oliveira, Erick Prado] UNESP Sch Med UNESP, Botucatu, SP, Brazil.
   [Paganini Burini, Franz Homero] Univ Sao Paulo, Sao Paulo, Brazil.
C3 Universidade de Sao Paulo
RP Burini, RC (corresponding author), UNESP Sch Med, Dept Publ Hlth, Ctr Nutr & Phys Exercise Metab, Botucatu, SP, Brazil.
EM burini@fmb.unesp.br
RI McLellan, Katia/I-2556-2012; de Oliveira, Erick/D-1138-2011
OI P. de Oliveira, Erick/0000-0001-8989-8344
FU CNPq; CAPES; FAPESP
FX CNPq, CAPES and FAPESP for the financial support and GAP (a statistical
   support of Botucatu School of Medicine) for the statistical analysis.
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NR 68
TC 25
Z9 25
U1 0
U2 8
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1758-5996
J9 DIABETOL METAB SYNDR
JI Diabetol. Metab. Syndr.
PD MAY 9
PY 2011
VL 3
AR 7
DI 10.1186/1758-5996-3-7
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 773LG
UT WOS:000291308200001
PM 21554698
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Guimaraes, ELM
   Empsen, C
   Geerts, A
   van Grunsven, LA
AF Guimaraes, Eduardo L. M.
   Empsen, Christophe
   Geerts, Albert
   van Grunsven, Leo A.
TI Advanced glycation end products induce production of reactive oxygen
   species via the activation of NADPH oxidase in murine hepatic stellate
   cells
SO JOURNAL OF HEPATOLOGY
LA English
DT Article
DE Advanced glycation end products; Reactive oxygen species; NADPH oxidase;
   NAFLD; Hepatic stellate cell
ID PROTEIN-KINASE-C; SCAVENGER-RECEPTOR; LIVER-CIRRHOSIS; ELEVATED LEVELS;
   PKC-DELTA; EXPRESSION; INHIBITOR; PATHWAY; KUPFFER; STRESS
AB Background & Aims: Advanced glycation end products are known to play an important role in the metabolic syndrome and were recently suggested to contribute to liver fibrosis development. However, little is known about the effect of advanced glycation end products on hepatic stellate cells, the major contributors to liver fibrosis development. We therefore studied the effect of advanced glycation end products on reactive oxygen species generation, a main feature for the activation hepatic stellate cells.
   Methods: Three different types of advanced glycation end products were generated by BSA incubation with different substrates. The presence of advanced glycation end product receptors was examined by RTq-PCR, immunofluorescence and western blotting. Reactive oxygen species production was measured using DCFH-DA.
   Results: Hepatic stellate cells express five advanced glycation end product receptors: Galectin-3, CD36, SR-Al, SR-BI and RAGE. All receptors, except SR-BI, showed up-regulation during HSC activation. All three advanced glycation end product types induced reactive oxygen species generation. DPI and NSC, a NADPH oxidase and a Rac1 inhibitor respectively, inhibited reactive oxygen species production. Rottlerin, a molecule often used as a PKC delta inhibitor, also abrogated reactive oxygen species production. SiRNA mediated knockdown of p47(phox), Rac1 and PKC delta decreased reactive oxygen species production induced by advanced glycation end products, establishing a role for these proteins in reactive oxygen species induction.
   Conclusions: The demonstration of advanced glycation end product-induced reactive oxygen species generation in hepatic stellate cells unveils a potential new route through which advanced glycation end products induce liver fibrosis in the metabolic syndrome. (C) 2010 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
C1 [Guimaraes, Eduardo L. M.; Empsen, Christophe; Geerts, Albert; van Grunsven, Leo A.] Vrije Univ Brussel, Dept Cell Biol, B-1090 Brussels, Belgium.
C3 Vrije Universiteit Brussel
RP van Grunsven, LA (corresponding author), Vrije Univ Brussel, Dept Cell Biol, Laarbeeklaan 103, B-1090 Brussels, Belgium.
EM leo.van.grunsven@vub.ac.be
RI ; van Grunsven, Leo/E-5839-2010
OI Guimaraes, Eduardo/0009-0007-9988-908X; van Grunsven,
   Leo/0000-0002-0990-7034
FU FWO-V (Fonds voor Wetenschappelijk Onderzoek - Vlaanderen) [G.0512.04,
   G.0652.06, G.0229.08, G.0651.06]; OZR (Research Council of Vrije
   Universiteit Brussel) [OZR1432-BOF, OZR1149BOF, GOA48, OZR1600BOF,
   OZR1226, OZR1219]; EASL (European Association for the Study of the
   Liver); I.A.P. (Belgian Science Policy Bureau) [P6/36]; EU; Roche;
   Schering-Plough;  [IWT/SB/61314]
FX We remember Professor Albert Geerts who passed away during the
   finalization of this study. We are grateful to him for all his
   enthusiasm and support which made the realisation of this project
   possible. This paper is in his honour. The authors who have taken part
   in this study declared that they do not have anything to declare
   regarding conflict of interest with respect to this manuscript. They
   declared the following sources of funding for this study. Grant Support:
   FWO-V (Fonds voor Wetenschappelijk Onderzoek - Vlaanderen), grants
   G.0512.04, G.0652.06, G.0229.08, G.0651.06; OZR (Research Council of
   Vrije Universiteit Brussel) Grants OZR1432-BOF, OZR1149BOF, GOA48,
   OZR1600BOF, OZR1226, OZR1219; EASL (European Association for the Study
   of the Liver) 2007 Sheila Sherlock Entry Level Fellowship; I.A.P.
   (Belgian Science Policy Bureau) phase VI contract P6/36; IWT/SB/61314;
   EU 6th Framework program. Roche and Schering-Plough unconditional grant.
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NR 31
TC 179
Z9 188
U1 4
U2 56
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0168-8278
EI 1600-0641
J9 J HEPATOL
JI J. Hepatol.
PD MAR
PY 2010
VL 52
IS 3
BP 389
EP 397
DI 10.1016/j.jhep.2009.12.007
PG 9
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 582EC
UT WOS:000276577900012
PM 20133001
DA 2025-06-11
ER

PT J
AU Kelishadi, R
   Cook, SR
   Amra, B
   Adibi, A
AF Kelishadi, Roya
   Cook, Stephen R.
   Amra, Babak
   Adibi, Atoosa
TI Factors associated with insulin resistance and non-alcoholic fatty liver
   disease among youths
SO ATHEROSCLEROSIS
LA English
DT Article
DE Insulin resistance; Fatty liver; Adolescents; Lifestyle; Oxidation;
   Inflammation; Apolipoprotein
ID VISCERAL ADIPOSE-TISSUE; METABOLIC SYNDROME; CARDIORESPIRATORY FITNESS;
   PHYSICAL-ACTIVITY; WEIGHT STATUS; RISK-FACTORS; CHILDREN; ADOLESCENTS;
   PREVALENCE; MARKERS
AB Objectives: To compare the cardio-metabolic risk factors, fitness and lifestyle among adolescents with and without weight disorders and/or metabolic abnormality, and to identify the factors associated with insulin resistance and non-alcoholic fatty liver disease (NAFLD) in this age group.
   Methods: This cross-sectional study comprised 100 adolescents (12-18 years) consisting of four subgroups of normal weight/obese with and without components of the metabolic syndrome. Fasting blood glucose, insulin, lipid profile, apolipoproteins A, B, CRP, oxidized-LDL, malondialdehyde and alanine aminotransferase (ALT) were examined. Cardiorespiratory fitness (CRF) and the sonographic findings of liver and carotid intima media thickness were determined.
   Results: Overall 95 participants completed all tests. Serum lipids, lipoproteins, the markers of inflammation and oxidative stress as well as the C-IMT of normal weight children with a metabolic abnormality were similar to obese children. CRF had the highest inverse correlation with HOMA-IR and ALT. Physical activity and healthy eating index had similar inverse correlation with HOMA-IR and ALT. ApoB/ApoA-1 had significant independent association with upper quartiles of HOMA-IR and ALT. Waist circumference and ApoB/ApoA-1 ratio had the highest odds ratio in increasing the risk of insulin resistance and NAFLD, whereas CRF followed by healthy eating index decreased this risk significantly. C-IMT was significantly associated with insulin resistance and NAFLD.
   Conclusions: We found significant associations between insulin resistance and NAFLD, and similar risk factors and protective factors for these two inter-related disorders; in this regard the role of CRF and apolipoprotein B to apolipoprotein A-I (ApoB/ApoA-I) ratio in the pediatric age group is underscored. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
C1 [Kelishadi, Roya] Isfahan Univ Med Sci, Isfahan Cardiovasc Res Ctr, Pediat Prevent Cardiol Dept, Esfahan, Iran.
   [Cook, Stephen R.] Univ Rochester, Med Ctr, Dept Pediat, New York, NY USA.
   [Amra, Babak; Adibi, Atoosa] Isfahan Univ Med Sci, Isfahan Sch Med, Esfahan, Iran.
C3 Isfahan University of Medical Sciences; University of Rochester; Isfahan
   University of Medical Sciences
RP Kelishadi, R (corresponding author), Isfahan Univ Med Sci, Isfahan Cardiovasc Res Ctr, Pediat Prevent Cardiol Dept, POB 81465-1148, Esfahan, Iran.
EM kroya@aap.net
RI amra, babak/B-9450-2018; Adibi, Atoosa/D-2025-2018; Kelishadi,
   Roya/E-6154-2012
OI Adibi, Atoosa/0000-0003-4830-9552; Amra, Babak/0000-0001-9606-7434;
   Kelishadi, Roya/0000-0001-7455-1495
FU Isfahan Cardiovascular Research Center; WHO; Isfahan University of
   Medical Sciences
FX Grant/funding support: This study is funded by Isfahan Cardiovascular
   Research Center, a WHO Collaborating center in the EMR, and affiliated
   to Isfahan University of Medical Sciences.
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NR 29
TC 71
Z9 75
U1 0
U2 11
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0021-9150
J9 ATHEROSCLEROSIS
JI Atherosclerosis
PD JUN
PY 2009
VL 204
IS 2
BP 538
EP 543
DI 10.1016/j.atherosclerosis.2008.09.034
PG 6
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 460PW
UT WOS:000267200600038
PM 19013572
DA 2025-06-11
ER

PT J
AU Kujiraoka, T
   Satoh, Y
   Ayaori, M
   Shiraishi, Y
   Arai-Nakaya, Y
   Hakuno, D
   Yada, H
   Kuwada, N
   Endo, S
   Isoda, K
   Adachi, T
AF Kujiraoka, Takehiko
   Satoh, Yasushi
   Ayaori, Makoto
   Shiraishi, Yasunaga
   Arai-Nakaya, Yuko
   Hakuno, Daihiko
   Yada, Hirotaka
   Kuwada, Naruo
   Endo, Shogo
   Isoda, Kikuo
   Adachi, Takeshi
TI Hepatic Extracellular Signal-Regulated Kinase 2 Suppresses Endoplasmic
   Reticulum Stress and Protects From Oxidative Stress and Endothelial
   Dysfunction
SO JOURNAL OF THE AMERICAN HEART ASSOCIATION
LA English
DT Article
DE diabetes mellitus; insulin; liver; metabolism; nitric oxide
ID FATTY LIVER-DISEASE; VASCULAR SMOOTH-MUSCLE; INTIMA-MEDIA THICKNESS;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; CAROTID ATHEROSCLEROSIS;
   DIABETIC COMPLICATIONS; CARDIOVASCULAR-DISEASE; S-GLUTATHIOLATION;
   NITRIC-OXIDE
AB Background-Insulin signaling comprises 2 major cascades: the insulin receptor substrate/phosphatidylinositol 3'-kinase/protein kinase B and Ras/Raf/mitogen-activated protein kinase/kinase/ERK pathways. While many studies on the tissue-specific effects of the insulin receptor substrate/phosphatidylinositol 3'-kinase/protein kinase B pathway have been conducted, the role of the other cascade in tissue-specific insulin resistance has not been investigated. High glucose/fatty acid toxicity, inflammation, and oxidative stress, all of which are associated with insulin resistance, can activate ERK. The liver plays a central role in metabolism, and hepatosteatosis is associated with vascular diseases. The aim of study was to elucidate the role of hepatic ERK2 in hepatosteatosis, metabolic remodeling, and endothelial dysfunction.
   Methods and Results-We created liver-specific ERK2 knockout mice and fed them with a high-fat/high-sucrose diet for 20 weeks. The high-fat/high-sucrose diet-fed liver-specific ERK2 knockout mice exhibited a marked deterioration in hepatosteatosis and metabolic remodeling represented by impairment of glucose tolerance and decreased insulin sensitivity without changes in body weight, blood pressure, and serum cholesterol/triglyceride levels. In the mice, endoplasmic reticulum stress was induced together with decreased mRNA and protein expressions of hepatic sarco/endoplasmic reticulum Ca2+-ATPase 2. In a hepatoma cell line, inhibition of ERK activation-induced endoplasmic reticulum stress only in the presence of palmitate. Vascular reactive oxygen species were elevated with upregulation of nicotinamide adenine dinucleotide phosphate oxidase1 (Nox1) and Nox4 and decreased phosphorylation of endothelial nitric oxide synthase, which resulted in the remarkable endothelial dysfunction in high-fat/high-sucrose diet-fed liver-specific ERK2 knockout mice.
   Conclusions-Hepatic ERK2 suppresses endoplasmic reticulum stress and hepatosteatosis in vivo, which results in protection from vascular oxidative stress and endothelial dysfunction. These findings demonstrate a novel role of hepatic ERK2 in obese-induced insulin resistance in the protection from hepatovascular metabolic remodeling and vascular diseases.
C1 [Kujiraoka, Takehiko; Shiraishi, Yasunaga; Arai-Nakaya, Yuko; Hakuno, Daihiko; Yada, Hirotaka; Isoda, Kikuo] Natl Def Med Coll, Dept Internal Med, Div Cardiovasc Med, Tokorozawa, Saitama 3598513, Japan.
   [Ayaori, Makoto] Natl Def Med Coll, Dept Internal Med, Div Antiaging & Vasc Med, Tokorozawa, Saitama 3598513, Japan.
   [Satoh, Yasushi] Natl Def Med Coll, Dept Anesthesiol, Tokorozawa, Saitama 3598513, Japan.
   [Kuwada, Naruo] Japan Air Self Def Force, Aeromed Lab, Sayama, Osaka, Japan.
   [Endo, Shogo] Tokyo Metropolitan Geriatr Hosp, Aging Neurosci Res Team, Tokyo 173, Japan.
   [Endo, Shogo] Inst Gerontol, Tokyo, Japan.
C3 National Defense Medical College - Japan; National Defense Medical
   College - Japan; National Defense Medical College - Japan; Tokyo
   Metropolitan Institute of Gerontology
RP Adachi, T (corresponding author), Natl Def Med Coll, Dept Internal Med 1, Div Cardiovasc Med, 3-2 Namiki, Tokorozawa, Saitama 3598513, Japan.
EM tadachi@ndmc.ac.jp
RI Endo, Shogo/LKJ-5968-2024
OI Endo, Shogo/0000-0002-3948-8723
FU Ministry of Defense; Mitsukoshi Health and Welfare Foundation;
   Grants-in-Aid for Scientific Research [25560382] Funding Source: KAKEN
FX This work was supported in part by a grant from the Ministry of Defense
   and the Research Fund of the Mitsukoshi Health and Welfare Foundation.
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NR 53
TC 33
Z9 37
U1 0
U2 6
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2047-9980
J9 J AM HEART ASSOC
JI J. Am. Heart Assoc.
PD AUG
PY 2013
VL 2
IS 4
AR e000361
DI 10.1161/JAHA.113.000361
PG 18
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 243TP
UT WOS:000326340900019
PM 23954796
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Ghulam, A
   Bonaccio, M
   Costanzo, S
   Bracone, F
   Gianfagna, F
   de Gaetano, G
   Iacoviello, L
AF Ghulam, Anwal
   Bonaccio, Marialaura
   Costanzo, Simona
   Bracone, Francesca
   Gianfagna, Francesco
   de Gaetano, Giovanni
   Iacoviello, Licia
TI Psychological Resilience, Cardiovascular Disease, and Metabolic
   Disturbances: A Systematic Review
SO FRONTIERS IN PSYCHOLOGY
LA English
DT Review
DE systematic review; cardiovascular disease; psychological resilience;
   metabolic disturbance; hardiness
ID STRESS RESILIENCE; RISK; ADOLESCENCE; OUTCOMES; HEALTH; DISCRIMINATION;
   AMERICAN
AB Background: Positive psychosocial factors can play an important role in the development of cardiovascular disease (CVD). Among them, psychological resilience (PR) is defined as the capacity of responding positively to stressful events. Our aim was to assess whether PR is associated with CVD or metabolic disturbances through a systematic review.
   Methods: We gathered articles from PubMed, Web of Science, PsycInfo, and Google Scholar up to October 28, 2021. We included articles that were in English, were observational, and had PR examined as exposure. The CVD outcomes were either clinical or metabolic outcomes (i.e., dyslipidemia, obesity, metabolic syndrome, hypertension, and diabetes).
   Results: Our literature search identified 3,800 studies, of which 17 met the inclusion criteria. Of them, seven were longitudinal and 10 cross-sectional, and 13 were on adults and four on children. The exposure assessment was heterogeneous, i.e., 12 studies used different kinds of self-administered questionnaires and five used interviews with a psychologist. Regarding outcomes, five studies investigated CVD, seven obesity, one metabolic syndrome, two hypertension, four dyslipidemia, and four diabetes. In longitudinal studies, PR was found to have an inverse association with included outcomes in five studies from the Swedish military conscription cohort but had no association with CVD in a study on African-American women and was associated with slower progression of diabetes in a general population. The cross-sectional studies showed that the prevalence of disease was not associated with PR in many cases but the progression of disease was associated with PR.
   Conclusion: PR seems to have a possibly favorable association with CVD and metabolic disturbances that differs according to the type of outcome and population. Our study limitations are given by the small number of studies available and the heterogeneity in PR measurement.
   Systematic Review Registration: [https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=237109], identifier [CRD42021237109].
C1 [Ghulam, Anwal; Gianfagna, Francesco; Iacoviello, Licia] Univ Insubria, Dept Med & Surg, Res Ctr Epidemiol & Prevent Med, Varese, Italy.
   [Bonaccio, Marialaura; Costanzo, Simona; Bracone, Francesca; de Gaetano, Giovanni; Iacoviello, Licia] NEUROMED, Dept Epidemiol & Prevent, Ist Ricovero Cura Carattere Sci IRCCS, Pozzilli, Italy.
   [Gianfagna, Francesco] Mediterranea Cardioctr, Naples, Italy.
C3 University of Insubria; IRCCS Neuromed
RP Bonaccio, M (corresponding author), NEUROMED, Dept Epidemiol & Prevent, Ist Ricovero Cura Carattere Sci IRCCS, Pozzilli, Italy.
EM marialaura.bonaccio@moli-sani.org
RI Costanzo, Simona/K-5076-2016; Iacoviello, Licia/AGX-7071-2022; Bonaccio,
   Marialaura/K-7678-2016; Bracone, Francesca/ABF-6072-2020; Gianfagna,
   Francesco/K-4561-2016; Iacoviello, Licia/K-4676-2016; ghulam,
   anwal/AHH-4298-2022
OI Gianfagna, Francesco/0000-0003-4615-0816; Iacoviello,
   Licia/0000-0003-0514-5885; ghulam, anwal/0000-0001-7550-325X
FU Lombardy Region [7082/2020]; AXA (AXA Research Fund-Call); Italian
   Ministry of Health [2019-2022]
FX This work was partially supported by the Lombardy Region (DGWelfare no.
   7082/2020) for LOST in Lombardy Project and AXA (AXA Research Fund-Call
   for Proposals COVID19) for LOST in Italy Project and Italian Ministry of
   Health (Ricerca Corrente 2019-2022). The funders had no role in study
   design, data collection, analysis, interpretation, and writing of the
   manuscript.
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NR 44
TC 17
Z9 18
U1 0
U2 16
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-1078
J9 FRONT PSYCHOL
JI Front. Psychol.
PD FEB 24
PY 2022
VL 13
AR 817298
DI 10.3389/fpsyg.2022.817298
PG 12
WC Psychology, Multidisciplinary
WE Social Science Citation Index (SSCI)
SC Psychology
GA ZX7JT
UT WOS:000772070900001
PM 35282220
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Deshmukh, V
   Farishta, F
   Bhole, M
AF Deshmukh, Vaishali
   Farishta, Faraz
   Bhole, Milind
TI Thyroid Dysfunction in Patients with Metabolic Syndrome: A
   Cross-Sectional, Epidemiological, Pan-India Study
SO INTERNATIONAL JOURNAL OF ENDOCRINOLOGY
LA English
DT Article
ID SUBCLINICAL HYPOTHYROIDISM; INSULIN-RESISTANCE; OXIDATIVE STRESS;
   ASSOCIATION; PREVALENCE; WOMEN; RISK
AB Background. This study was conducted to assess the prevalence and clinical and epidemiological factors of thyroid dysfunction (TD) in Indian patients diagnosed with metabolic syndrome (MetS). Methods. In this cross-sectional study, 432 adults with an established diagnosis of MetS were enrolled across ten centers in India. Anthropometric measurements and vital signs were noted. Blood samples were tested for hemogram, coagulogram, lipid profile, and thyroid function. Fasting plasma glucose (FPG) and fasting plasma insulin were used for the calculation of homeostasis model assessment-estimated insulin resistance (HOMA-IR). Overt hypothyroidism was defined as thyroid-stimulating hormone 1.4pg/mL; subclinical hypothyroidism as TSH>4.50IU/mL with FT4=0.8-1.8ng/dL and FT3=1.4-4.4pg/mL; overt hyperthyroidism as TSH<0.45IU/mL with FT4>1.8ng/dL and FT3>4.4pg/mL; and subclinical hyperthyroidism as TSH<0.45IU/mL with FT4=0.8-1.8ng/dL and FT3=1.4-4.4pg/mL. Results. About 121 out of 432 patients (28%) were diagnosed with TD (meanage +/- SD: 47.9 +/- 10.96 years), with women predominance (75% versus 25%). Most patients were in the >45 years of age group (men: 63%; women: 59%). TD was associated with high waist circumference (99.17%), reduced high-density lipoprotein-C (87.60%), raised HOMA-IR (86.78%), systolic blood pressure (77.69%), diastolic blood pressure (59.50%), fasting glucose (58.68%), and triglycerides (33.06%). Overt hypothyroidism was reported in 17.59% (N=76) of patients. Subclinical hypothyroidism, overt hypothyroidism, and subclinical hyperthyroidism were reported in 8.10%, 1.60%, and 0.70% patients with newly occurred TD, respectively. No case of overt hyperthyroidism was present in these patients. Conclusion. Hypothyroidism was the most common TD in Indian patients with MetS. A large proportion of TD cases diagnosed during the study highlight the need for vigilant thyroid screening in patients with MetS in a real-life setting.
C1 [Deshmukh, Vaishali] Shree Hosp, Pune, Maharashtra, India.
   [Farishta, Faraz] FS Endocrine & Diabet Ctr, Hyderabad, India.
   [Bhole, Milind] Abbott India Ltd, Bombay, Maharashtra, India.
RP Bhole, M (corresponding author), Abbott India Ltd, Bombay, Maharashtra, India.
EM mbhole170@gmail.com
FU Abbott India Ltd.
FX The authors thank the study participants without whom this study would
   not have been accomplished, as well as the investigators for their
   participation in this study. The authors also thank Dr. Natasha Das
   (freelance medical writer, Delhi) and Dr. Shalini Nair (Abbott) for
   providing writing and editing assistance in developing this manuscript.
   This study was funded by Abbott India Ltd.
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NR 32
TC 18
Z9 21
U1 0
U2 1
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1687-8337
EI 1687-8345
J9 INT J ENDOCRINOL
JI Int. J. Endocrinol.
PY 2018
VL 2018
AR 2930251
DI 10.1155/2018/2930251
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA HH3JP
UT WOS:000455616100001
PM 30675157
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Tominaga, T
   Dutta, RK
   Joladarashi, D
   Doi, T
   Reddy, JK
   Kanwar, YS
AF Tominaga, Tatsuya
   Dutta, Rajesh K.
   Joladarashi, Darukeshwara
   Doi, Toshio
   Reddy, Janardan K.
   Kanwar, Yashpal S.
TI Transcriptional and Translational Modulation of myo-Inositol
   Oxygenase (Miox) by Fatty Acids IMPLICATIONS IN RENAL TUBULAR INJURY
   INDUCED IN OBESITY AND DIABETES
SO JOURNAL OF BIOLOGICAL CHEMISTRY
LA English
DT Article
ID OXIDOREDUCTASE/MYO-INOSITOL OXYGENASE; METABOLIC SYNDROME; OXIDATIVE
   STRESS; INSULIN-RESISTANCE; EPITHELIAL-CELLS; GENE-EXPRESSION;
   KIDNEY-DISEASE; HIGH-GLUCOSE; PROTEIN; ALBUMIN
AB The kidney is one of the target organs for various metabolic diseases, including diabetes, metabolic syndrome, and obesity. Most of the metabolic studies underscore glomerular pathobiology, although the tubulo-interstitial compartment has been underemphasized. This study highlights mechanisms concerning the pathobiology of tubular injury in the context of myoinositol oxygenase (Miox), a tubular enzyme. The kidneys of mice fed a high fat diet (HFD) had increased Miox expression and activity, and the latter was related to phosphorylation of serine/threonine residues. Also, expression of sterol regulatory element-binding protein1 (Srebp1) and markers of cellular/nuclear damage was increased along with accentuated apoptosis and loss of tubular brush border. Similar results were observed in cells treated with palmitate/BSA. Multiple sterol-response elements and E-box motifs were found in the miox promoter, and its activity was modulated by palmitate/BSA. Electrophoretic mobility and ChIP assays confirmed binding of Srebp to consensus sequences of the miox promoter. Exposure of palmitate/ BSA-treated cells to rapamycin normalized Miox expression and prevented Srebp1 nuclear translocation. In addition, rapamycin treatment reduced p53 expression and apoptosis. Like rapamycin, srebp siRNA reduced Miox expression. Increased expression of Miox was associated with the generation of reactive oxygen species (ROS) in kidney tubules of mice fed an HFD and cell exposed to palmitate/BSA. Both miox and srebp1 siRNAs reduced generation of ROS. Collectively, these findings suggest that HFD or fatty acids modulate transcriptional, translational, and post-translational regulation of Miox expression/activity and underscore Miox being a novel target of the transcription factor Srebp1. Conceivably, activation of the mTORC1/Srebp1/Miox pathway leads to the generation of ROS culminating into tubulo-interstitial injury in states of obesity.
C1 [Kanwar, Yashpal S.] Northwestern Univ, Dept Pathol, Feinberg Sch Med, Chicago, IL 60611 USA.
   [Doi, Toshio] Univ Tokushima, Dept Nephrol, Tokushima 770, Japan.
C3 Northwestern University; Feinberg School of Medicine; Tokushima
   University
RP Kanwar, YS (corresponding author), Northwestern Univ, Sch Med, Dept Pathol, 300 E Chicago Ave, Chicago, IL 60611 USA.
EM y-kanwar@northwestern.edu
RI Dutta, Rajesh/J-7790-2019
OI Dutta, Rajesh Kumar/0000-0002-1394-0961
FU National Institutes of Health [DK60636]; Manpei Suzuki Diabetes
   Foundation
FX This work was supported by National Institutes of Health Grant DK60636
   and the Manpei Suzuki Diabetes Foundation. The authors declare that they
   have no conflicts of interest with the contents of this article. The
   content is solely the responsibility of the authors and does not
   necessarily represent the official views of the National Institutes of
   Health.
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NR 56
TC 30
Z9 33
U1 0
U2 15
PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3996 USA
EI 1083-351X
J9 J BIOL CHEM
JI J. Biol. Chem.
PD JAN 15
PY 2016
VL 291
IS 3
BP 1348
EP 1367
DI 10.1074/jbc.M115.698191
PG 20
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA DA8PR
UT WOS:000368068300028
PM 26578517
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Pereira, CD
   Severo, M
   Rafael, L
   Martins, MJ
   Neves, D
AF Pereira, Cidalia D.
   Severo, Milton
   Rafael, Luisa
   Martins, Maria Joao
   Neves, Delminda
TI Effects of natural mineral-rich water consumption on the expression of
   sirtuin 1 and angiogenic factors in the erectile tissue of rats with
   fructose-induced metabolic syndrome
SO ASIAN JOURNAL OF ANDROLOGY
LA English
DT Article
DE angiopoietins; erectile tissue; hypersaline sodium-rich naturally
   sparkling mineral water; receptors; sirtuin 1; vascular endothelial
   growth factor
ID ENDOTHELIAL GROWTH-FACTOR; NITRIC-OXIDE; OXIDATIVE STRESS;
   INSULIN-RESISTANCE; CALORIE RESTRICTION; ENERGY RESTRICTION; CORPUS
   CAVERNOSUM; DYSFUNCTION; VEGF; MAGNESIUM
AB Consuming a high-fructose diet induces metabolic syndrome (MS)-like features, including endothelial dysfunction. Erectile dysfunction is an early manifestation of endothelial dysfunction and systemic vascular disease. Because mineral deficiency intensifies the deleterious effects of fructose consumption and mineral ingestion is protective against MS, we aimed to characterize the effects of 8 weeks of natural mineral-rich water consumption on the structural organization and expression of vascular growth factors and receptors on the corpus cavernosum (CC) in 10% fructose-fed Sprague-Dawley rats (FRUCT). Differences were not observed in the organization of the CC either on the expression of vascular endothelial growth factor (VEGF) or the components of the angiopoietins/Tie2 system. However, opposing expression patterns were observed for VEGF receptors (an increase and a decrease for VEGFR1 and VEGFR2, respectively) in FRUCT animals, with these patterns being strengthened by mineral-rich water ingestion. Mineral-rich water ingestion (FRUCTMIN) increased the proportion of smooth muscle cells compared with FRUCT rats and induced an upregulatory tendency of sirtuin 1 expression compared with the control and FRUCT groups. Western blot results were consistent with the dual immunofluorescence evaluation. Plasma oxidized low-density lipoprotein and plasma testosterone levels were similar among the experimental groups, although a tendency for an increase in the former was observed in the FRUCTMIN group. The mineral-rich water-treated rats presented changes similar to those observed in rats treated with MS-protective polyphenol-rich beverages or subjected to energy restriction, which led us to hypothesize that the effects of mineral-rich water consumption may be more vast than those directly observed in this study.
C1 [Pereira, Cidalia D.; Martins, Maria Joao] Univ Porto, Fac Med, Dept Biochem, P-4100 Oporto, Portugal.
   [Severo, Milton] Univ Porto, Fac Med, Dept Clin Epidemiol Predict Med & Publ Hlth, P-4100 Oporto, Portugal.
   [Rafael, Luisa] Sao Joao Hosp Ctr, EPE, Dept Clin Pathol, Oporto, Portugal.
   [Neves, Delminda] Univ Porto, Fac Med, Dept Expt Biol, P-4100 Oporto, Portugal.
   [Neves, Delminda] Univ Porto, Inst Mol & Cell Biol IBMC, P-4100 Oporto, Portugal.
C3 Universidade do Porto; Universidade do Porto; Sao Joao Hospital;
   Universidade do Porto; Universidade do Porto
RP Pereira, CD (corresponding author), Univ Porto, Fac Med, Dept Biochem, Rua Campo Alegre 823, P-4100 Oporto, Portugal.
EM pdm07003@med.up.pt
RI Martins, Maria João/ABC-8271-2021; Severo, Milton/I-3497-2012; Pereira,
   Cidalia Almeida/GPP-6411-2022
OI Severo, Milton/0000-0002-5787-4871; Martins, Maria
   Joao/0000-0002-3560-3261; Pereira, Cidalia Almeida/0000-0001-9934-9648;
   Neves, Delminda/0000-0002-3301-8376
FU FCT through the Centro de Farmacologia e Biopatalogia Quimica, Faculty
   of Medicine, Univ. of Porto [PEst-OE/SAU/UI0038/2011, U38/FCT]
FX This work was also supported by FCT (PEst-OE/SAU/UI0038/2011) through
   the Centro de Farmacologia e Biopatalogia Quimica (U38/FCT), Faculty of
   Medicine, Univ. of Porto, which integrates the Biochemistry Dept,
   Faculty of Medicine, Univ. of Porto.
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NR 77
TC 11
Z9 12
U1 0
U2 8
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, Maharashtra, INDIA
SN 1008-682X
EI 1745-7262
J9 ASIAN J ANDROL
JI Asian J. Androl.
PD JUL
PY 2014
VL 16
IS 4
BP 631
EP 638
DI 10.4103/1008-682X.122869
PG 8
WC Andrology; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Urology & Nephrology
GA AM5LX
UT WOS:000339901700026
PM 24625878
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU de Chantemèle, EJB
   Vessières, E
   Guihot, AL
   Toutain, B
   Loufrani, L
   Henrion, D
AF de Chantemele, Eric J. Belin
   Vessieres, Emilie
   Guihot, Anne-Laure
   Toutain, Bertrand
   Loufrani, Laurent
   Henrion, Daniel
TI Cyclooxygenase-2 preserves flow-mediated remodelling in old obese Zucker
   rat mesenteric arteries
SO CARDIOVASCULAR RESEARCH
LA English
DT Article
DE Resistance arteries; Shear stress; Ageing; Cyclooxygenase-2; Metabolic
   syndrome
ID RESISTANCE ARTERIES; ENDOTHELIAL DYSFUNCTION; BLOOD-FLOW;
   INSULIN-RESISTANCE; NITRIC-OXIDE; VASCULAR REACTIVITY;
   MECHANICAL-BEHAVIOR; DEPENDENT DILATION; DIABETES-MELLITUS;
   HYPERTENSIVE-RATS
AB Resistance arteries have a key role in the control of local blood flow and pressure, and chronic increases in blood flow induce endothelium-dependent outward hypertrophic remodelling. The incidence of metabolic syndrome increases with age, and the combination of these two risk factors impairs endothelium integrity, in part through an inflammatory process. We hypothesized that cyclooxygenase-2 (COX2) would affect remodelling in 12-month-old obese rats compared with young rats.
   Mesenteric arteries of obese and lean Zucker rats were alternatively ligated to generate high flow (HF) in the median artery. After 21 days, arteries were isolated for in vitro analysis. After 21 days, outward hypertrophic remodelling occurred in HF arteries in obese (498 +/- 20 vs. 443 +/- 18 mu m intraluminal diameter in normal flow (NF) arteries, P < 0.01), but not in lean rats (454 +/- 17 vs. 432 +/- 14, NS; n = 12 per group). Endothelium-dependent (acetylcholine)-mediated relaxation (AMR) was lower in obese than in lean rats. AMR was reduced by NO-synthase blockade in all groups, and eNOS expression was higher in HF than in NF arteries without difference between lean and obese rats. Indomethacin further reduced AMR in HF arteries from obese rats only. Obesity increased COX2 immunostaining in mesenteric arteries. Acute COX2 inhibition (NS398) significantly reduced AMR in HF arteries from obese rats only, suggesting production of vasodilator prostanoid(s). In obese rats chronically treated with the COX2 inhibitor celecoxib, outward remodelling did not occur in HF arteries and AMR was improved without reaching the level found in lean rats.
   COX2 preserved in part flow-mediated arterial remodelling in old obese rats. Nevertheless, this effect was not sufficient to keep endothelium-dependent relaxation to the level obtained in lean rats.
C1 [de Chantemele, Eric J. Belin; Vessieres, Emilie; Guihot, Anne-Laure; Toutain, Bertrand; Loufrani, Laurent; Henrion, Daniel] Univ Angers, Dept Integrated Neurovasc Biol, CNRS, CHU Angers,INSERM,UMR 6214,U771, Angers, France.
C3 Institut National de la Sante et de la Recherche Medicale (Inserm);
   Centre National de la Recherche Scientifique (CNRS); Universite
   d'Angers; Centre Hospitalier Universitaire d'Angers
RP Henrion, D (corresponding author), Univ Angers, Dept Integrated Neurovasc Biol, CNRS, CHU Angers,INSERM,UMR 6214,U771, Angers, France.
EM daniel.henrion@univ-angers.fr
RI Henrion, Daniel/N-7023-2015; Toutain, Bertrand/M-1982-2015; vessieres,
   emilie/K-1894-2015; de Chantemele, Eric/H-8923-2019; loufrani,
   laurent/K-1713-2015; Henrion, Daniel/J-8141-2015
OI Belin de Chantemele, Eric J./0000-0002-0184-3830; Henrion,
   Daniel/0000-0003-1094-0285; Toutain, Bertrand/0000-0002-7571-4062
FU Foundation for Medical Research (FRM), Paris, France
FX This work was supported in part by the Foundation for Medical Research
   (FRM), Paris, France. E. B. C. was a post-doctoral fellow of the Centre
   National d'Etudes Spatiales (CNES), France.
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NR 48
TC 23
Z9 24
U1 0
U2 4
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0008-6363
EI 1755-3245
J9 CARDIOVASC RES
JI Cardiovasc. Res.
PD JUN 1
PY 2010
VL 86
IS 3
BP 516
EP 525
DI 10.1093/cvr/cvp411
PG 10
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 597BY
UT WOS:000277732000021
PM 20032084
OA Bronze
DA 2025-06-11
ER

PT J
AU Jun, JE
   Lee, SE
   Lee, YB
   Jee, JH
   Bae, JC
   Jin, SM
   Hur, KY
   Lee, MK
   Kim, JH
AF Jun, Ji Eun
   Lee, Seung-Eun
   Lee, You-Bin
   Jee, Jae Hwan
   Bae, Ji Cheol
   Jin, Sang-Man
   Hur, Kyu Yeon
   Lee, Moon-Kyu
   Kim, Jae Hyeon
TI Increase in serum albumin concentration is associated with prediabetes
   development and progression to overt diabetes independently of metabolic
   syndrome
SO PLOS ONE
LA English
DT Article
ID C-REACTIVE PROTEIN; BETA-CELL FUNCTION; OXIDATIVE STRESS;
   INSULIN-RESISTANCE; ANTIOXIDANT PROPERTIES; RISK-FACTORS;
   ATHEROSCLEROSIS; INFLAMMATION; POPULATION; PREDICTION
AB Aim
   Serum albumin concentration is associated with both type 2 diabetes and metabolic syndrome (MetS). We sought to investigate whether baseline serum albumin and change in serum albumin could be independent risk factors for prediabetes in subjects without MetS. We further examined the effect of serum albumin on progression to overt diabetes in subjects who developed prediabetes.
   Methods
   Among 10,792 participants without diabetes and MetS who consecutively underwent yearly health check-ups over six years, 9,807 subjects without incident MetS were enrolled in this longitudinal retrospective study. The risk of developing prediabetes (impared fasting glucose or hemoglobin A1c) was analyzed according to baseline and percent change in serum albumin concentration using Cox regression analysis. Serial changes in serum albumin concentration were measured from baseline to one year before prediabetes diagnosis, and then from the time of prediabetes diagnosis to progression to overt diabetes or final follow-up.
   Results
   A total of 4,398 incident cases of prediabetes developed during 35,807 person-years (median 3.8 years). The hazard ratio for incident prediabetes decreased as percent change in serum albumin concentration (quartiles and per 1%) increased in a crude and fully adjusted model. However, baseline serum albumin concentration itself was not associated with prediabetic risk. Serum albumin levels kept increasing until the end of follow-up in prediabetic subjects who returned to normal glycemic status, whereas these measures did not change in prediabetic subjects who developed type 2 diabetes. Serum albumin concentration measured at the end of follow-up was the highest in the regression group, compared to the stationary (p = 0.014) or progression groups (p = 0.009).
   Conclusions
   Increase in serum albumin concentration might protect against early glycemic deterioration and progression to type 2 diabetes even in subjects without MetS.
C1 [Jun, Ji Eun; Lee, Seung-Eun; Lee, You-Bin; Jin, Sang-Man; Hur, Kyu Yeon; Lee, Moon-Kyu; Kim, Jae Hyeon] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Med,Div Endocrinol & Metab, Seoul, South Korea.
   [Jee, Jae Hwan] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Hlth Promot Ctr, Seoul, South Korea.
   [Bae, Ji Cheol] Sungkyunkwan Univ, Sch Med, Samsung Changwon Hosp, Dept Med,Div Endocrinol & Metab, Chang Won, South Korea.
   [Kim, Jae Hyeon] Sungkyunkwan Univ, Sch Med, SAIHST, Dept Clin Res Design & Evaluat, Seoul, South Korea.
C3 Sungkyunkwan University (SKKU); Samsung Medical Center; Sungkyunkwan
   University (SKKU); Samsung Medical Center; Sungkyunkwan University
   (SKKU); Samsung Medical Center; Sungkyunkwan University (SKKU)
RP Kim, JH (corresponding author), Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Med,Div Endocrinol & Metab, Seoul, South Korea.; Kim, JH (corresponding author), Sungkyunkwan Univ, Sch Med, SAIHST, Dept Clin Res Design & Evaluat, Seoul, South Korea.
EM jaehyeon@skku.edu
RI Jin, Sang-Man/AFO-5933-2022
OI Jin, Sang-Man/0000-0001-5929-3627; Lee, You-Bin/0000-0003-4058-1738
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NR 28
TC 31
Z9 33
U1 0
U2 3
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD APR 21
PY 2017
VL 12
IS 4
AR e0176209
DI 10.1371/journal.pone.0176209
PG 13
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA ES9KN
UT WOS:000399876100033
PM 28430803
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Lang, F
   Guelinckx, I
   Lemetais, G
   Melander, O
AF Lang, Florian
   Guelinckx, Isabelle
   Lemetais, Guillaume
   Melander, Olle
TI Two Liters a Day Keep the Doctor Away? Considerations on the
   Pathophysiology of Suboptimal Fluid Intake in the Common Population
SO KIDNEY & BLOOD PRESSURE RESEARCH
LA English
DT Review
DE Copeptin; Glucocorticoids; Vasopressin; Metabolic syndrome; Cancer;
   Chronic kidney disease
ID GLUCOCORTICOID-INDUCIBLE KINASE; SGK1 REGULATES REORGANIZATION;
   NF-KAPPA-B; ORAI1 EXPRESSION; PLASMA COPEPTIN; HYPERTENSIVE MECHANISMS;
   MYOCARDIAL FIBROSIS; INSULIN-RESISTANCE; ACTIN CYTOSKELETON; SIGNALING
   PATHWAY
AB Suboptimal fluid intake may require enhanced release of antidiuretic hormone (ADH) or vasopressin for the maintenance of adequate hydration. Enhanced copeptin levels (reflecting enhanced vasopressin levels) in 25% of the common population are associated with enhanced risk of metabolic syndrome with abdominal obesity, type 2 diabetes, hypertension, coronary artery disease, heart failure, vascular dementia, cognitive impairment, microalbuminuria, chronic kidney disease, inflammatory bowel disease, cancer, and premature mortality. Vasopressin stimulates the release of glucocorticoids which in turn up-regulate the serum-and glucocorticoid-inducible kinase 1 (SGK1). Moreover, dehydration upregulates the transcription factor NFAT5, which in turn stimulates SGK1 expression. SGK1 is activated by insulin, growth factors and oxidative stress via phosphatidylinositide-3-kinase, 3-phosphoinositidedependent kinase PDK1 and mTOR. SGK1 is a powerful stimulator of Na+/K+-ATPase, carriers (e.g. the Na+, K+, 2Cl(-) cotransporter NKCC, the NaCl cotransporter NCC, the Na+/H+ exchanger NHE3, and the Na+ coupled glucose transporter SGLT1), and ion channels (e.g. the epithelial Na+ channel ENaC, the Ca2+ release activated Ca2+ channel Orai1 with its stimulator STIM1, and diverse K+ channels). SGK1 further participates in the regulation of the transcription factors nuclear factor kappa-B NF kappa B, p53, cAMP responsive element binding protein (CREB), activator protein-1, and forkhead transcription factor FKHR-L1 (FOXO3a). Enhanced SGK1 activity fosters the development of hypertension, obesity, diabetes, thrombosis, stroke, inflammation including inflammatory bowel disease and autoimmune disease, cardiac fibrosis, proteinuria, renal failure as well as tumor growth. The present brief review makes the case that suboptimal fluid intake in the common population may enhance vasopressin and glucocorticoid levels thus up-regulating SGK1 expression and favouring the development of SGK1 related pathologies. (C) 2017 The Author(s) Published by S. Karger AG, Basel
C1 [Lang, Florian] Univ Tubingen, Dept Physiol 1, Gmelinstr 5, D-72076 Tubingen, Germany.
   [Guelinckx, Isabelle; Lemetais, Guillaume] Danone Res, Palaiseau, France.
   [Melander, Olle] Lund Univ, Dept Clin Sci, Malmo, Sweden.
C3 Eberhard Karls University of Tubingen; Danone Nutricia; Lund University
RP Lang, F (corresponding author), Univ Tubingen, Dept Physiol 1, Gmelinstr 5, D-72076 Tubingen, Germany.
EM florian.lang@uni-tuebingen.de
OI Melander, Olle/0000-0002-2581-484X
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NR 111
TC 33
Z9 34
U1 0
U2 14
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1420-4096
EI 1423-0143
J9 KIDNEY BLOOD PRESS R
JI Kidney Blood Pressure Res.
PY 2017
VL 42
IS 3
BP 483
EP 494
DI 10.1159/000479640
PG 12
WC Physiology; Urology & Nephrology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology; Urology & Nephrology; Cardiovascular System & Cardiology
GA FM4GA
UT WOS:000414970500009
PM 28787716
OA gold
DA 2025-06-11
ER

PT J
AU Hwang, SH
   Kang, JM
   Seo, JH
   Han, KD
   Joo, YH
AF Hwang, Se-Hwan
   Kang, Jun-Myung
   Seo, Jae-Hyun
   Han, Kyung-do
   Joo, Young-Hoon
TI Gender Difference in the Epidemiological Association between Metabolic
   Syndrome and Olfactory Dysfunction: The Korea National Health and
   Nutrition Examination Survey
SO PLOS ONE
LA English
DT Article
ID DIABETES-MELLITUS; HORMONES; SMELL; RISK
AB Metabolic syndrome (MetS) is associated with a higher risk of morbidity and/or mortality for various chronic diseases. The aim of this study was to investigate the relationships of MetS and its components with olfactory dysfunction in a representative Korean population. We analyzed the data from the Korean National Health and Nutrition Examination Survey (2008-2010). A total of 11,609 adults who underwent otolaryngological examination were evaluated. The olfactory function was classified as normosmia or hyposmia by a self-report questionnaire according to the sense problems of smell during the past 3 months. MetS was diagnosed if a participant had at least three of the following: (1) WC >= 90 cm in men and >= 80 cm in women; (2) fasting blood sugar >= 100 mg/dL or medication use for elevated glucose; (3) fasting triglyceride >= 150 mg/dL or cholesterol-lowering medication use; (4) HDL-cholesterol <40 mg/dL in men and <50 mg/dL in women or cholesterol-lowering medication use; and (5) SBP >= 130 mmHg and/or DBP >= 85 mmHg or antihypertensive drug use for patients with a history of hypertension. The prevalence of olfactory dysfunction in the study population was 6.3%. The prevalence of olfactory dysfunction was significantly higher in older people with MetS than in those without MetS in both sexes (male, 42.0 +/- 3.4% vs. 34.7 +/- 0.9%, p = 0.0354; female, 46.2 +/- 2.8% vs. 37.8 +/- 0.8%, p = 0.0026). However, elevated waist circumference, elevated fasting glucose, elevated triglycerides, reduced HDL cholesterol, elevated blood pressure, severe stress, depressed mood, and suicidal ideation were significantly associated with olfactory dysfunction only in women. After controlling for confounders, olfactory dysfunction was significantly associated with MetS (odds ratio, 1.352; 95% confidence interval, 1.005-1.820) only in women. MetS are associated with olfactory dysfunction only in Korean women.
C1 [Hwang, Se-Hwan; Kang, Jun-Myung; Seo, Jae-Hyun; Joo, Young-Hoon] Catholic Univ Korea, Dept Otolaryngol Head & Neck Surg, Seoul, South Korea.
   [Han, Kyung-do] Catholic Univ Korea, Dept Biostat, Coll Med, Seoul, South Korea.
C3 Catholic University of Korea; Catholic University of Korea
RP Joo, YH (corresponding author), Catholic Univ Korea, Dept Otolaryngol Head & Neck Surg, Seoul, South Korea.
EM joodoct@catholic.ac.kr
RI Han, Kyungdo/JKH-7628-2023; Joo, Young Hoon/AAU-7285-2020
OI Joo, Young Hoon/0000-0002-4662-1916; Hwang, Se Hwan/0000-0002-2838-7820
CR Banos G., 2011, Cardiovascular & Hematological Agents in Medicinal Chemistry, V9, P137
   Brady S, 2013, CHEM SENSES, V38, P497, DOI 10.1093/chemse/bjt013
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NR 23
TC 15
Z9 15
U1 0
U2 1
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD FEB 9
PY 2016
VL 11
IS 2
AR e0148813
DI 10.1371/journal.pone.0148813
PG 10
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA DD6MN
UT WOS:000370038400090
PM 26859830
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Hanslik, G
   Wallaschofski, H
   Dietz, A
   Riester, A
   Reincke, M
   Allolio, B
   Lang, K
   Quack, I
   Rump, LC
   Willenberg, HS
   Beuschlein, F
   Quinkler, M
   Hannemann, A
AF Hanslik, Gregor
   Wallaschofski, Henri
   Dietz, Anna
   Riester, Anna
   Reincke, Martin
   Allolio, Bruno
   Lang, Katharina
   Quack, Ivo
   Rump, Lars C.
   Willenberg, Holger S.
   Beuschlein, Felix
   Quinkler, Marcus
   Hannemann, Anke
CA German Conn's Registry
TI Increased prevalence of diabetes mellitus and the metabolic syndrome in
   patients with primary aldosteronism of the German Conn's Registry
SO EUROPEAN JOURNAL OF ENDOCRINOLOGY
LA English
DT Article
ID PRIMARY HYPERALDOSTERONISM; INSULIN SENSITIVITY; HYPERTENSIVE PATIENTS;
   OXIDATIVE STRESS; RENIN RATIO; GLUCOSE; DIAGNOSIS; POTASSIUM; SECRETION;
   HEALTH
AB Design: Abnormalities in glucose homeostasis have been described in patients with primary aldosteronism (PA) but most studies show inconsistent results. Therefore, we aimed to compare the prevalence of type 2 diabetes mellitus and metabolic syndrome (MetS) in newly diagnosed PA patients to a matched control cohort of the background population.
   Methods: In total, 305 PA patients of the prospective German Conn's Registry were compared to the population-based Study of Health In Pomerania (SHIP1; n=2454). A 1:1 match regarding sex, age, and BMI resulted in 269 matched pairs regarding type 2 diabetes and 183 matched pairs regarding MetS. Of the total, 153 PA patients underwent oral glucose tolerance testing (OGTT) at diagnosis and 38 PA patients were reevaluated at follow-up.
   Results: Type 2 diabetes and MetS were significantly more frequent in PA patients than in the control population (17.2% vs 10.4%, P=0.03; 56.8% vs 44.8%, P=0.02 respectively). Also, HbA1c levels were higher in PA patients than in controls (P<0.01). Of the total, 35.3% of non-diabetic PA patients showed an abnormal OGTT (1/4 newly diagnosed type 2 diabetes and 3/4 impaired glucose tolerance). PA patients with an abnormal OGTT at baseline presented with significantly improved 2 h OGTT glucose (P=0.01) at follow-up. We detected a negative correlation between 2 h OGTT glucose levels and serum potassium (P<0.01).
   Conclusions: Type 2 diabetes and MetS are more prevalent in patients with PA than in controls matched for sex, age, BMI, and blood pressure. This may explain in part the increased cardiovascular disease morbidity and mortality in PA patients.
C1 [Hanslik, Gregor; Quinkler, Marcus] Charite, Clin Endocrinol, Charite Campus Mitte, D-13353 Berlin, Germany.
   [Wallaschofski, Henri; Hannemann, Anke] Univ Med Greifswald, Inst Clin Chem & Lab Med, Greifswald, Germany.
   [Dietz, Anna; Riester, Anna; Reincke, Martin; Beuschlein, Felix] Univ Hosp Munich, Endocrinol & Metab, Med Klin & Poliklin 4, Munich, Germany.
   [Allolio, Bruno; Lang, Katharina] Univ Hosp Wuerzburg, Endocrinol & Diabet Unit, Dept Internal Med 1, Wurzburg, Germany.
   [Quack, Ivo; Rump, Lars C.] Univ Dusseldorf, Dept Nephrol, Fac Med, Dusseldorf, Germany.
   [Willenberg, Holger S.] Univ Rostock, Div Endocrinol & Metab, Med Ctr, D-18055 Rostock, Germany.
   [Quinkler, Marcus] Endocrinol Charlottenburg, D-10627 Berlin, Germany.
C3 Berlin Institute of Health; Free University of Berlin; Humboldt
   University of Berlin; Charite Universitatsmedizin Berlin; Universitat
   Greifswald; Greifswald Medical School; University of Munich; University
   of Wurzburg; Heinrich Heine University Dusseldorf; University of Rostock
RP Quinkler, M (corresponding author), Charite, Clin Endocrinol, Charite Campus Mitte, D-13353 Berlin, Germany.
EM marcus.quinkler@t-online.de
RI Beuschlein, Felix/N-1282-2018
OI Lang, Katharina/0000-0002-8294-7016; Quinkler,
   Marcus/0000-0003-4028-1671; Riester, Anna/0000-0003-3231-7435
FU Else Kroner-Fresenius-Stiftung, Germany; German Federal Ministry of
   Education and Research (BMBF) [01ZZ0403, 01ZZ0103, 01GI0883]; Ministry
   for Education, Research and Cultural Affairs; Ministry of Social Affairs
   of the Federal State of Mecklenburg-West Pomerania; Federal Ministry of
   Education and Research; Ministry of Cultural Affairs of the Federal
   State of Mecklenburg - West Pomerania [03IS2061A]; Instand e.V.
FX This research was supported by the Else Kroner-Fresenius-Stiftung,
   Germany. SHIP was funded by grants from the German Federal Ministry of
   Education and Research (BMBF, grants 01ZZ0403, 01ZZ0103, and 01GI0883),
   the Ministry for Education, Research and Cultural Affairs as well as the
   Ministry of Social Affairs of the Federal State of Mecklenburg-West
   Pomerania. This work is also part of the research project Greifswald
   Approach to Individualized Medicine (GANI_MED). The GANI_MED consortium
   is funded by the Federal Ministry of Education and Research and the
   Ministry of Cultural Affairs of the Federal State of Mecklenburg - West
   Pomerania (03IS2061A). Instand e.V. provided partial grant support for
   the determination of plasma samples and data analysis in SHIP.
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NR 52
TC 121
Z9 129
U1 0
U2 7
PU BIOSCIENTIFICA LTD
PI BRISTOL
PA STARLING HOUSE, 1600 BRISTOL PARKWAY N, BRISTOL, ENGLAND
SN 0804-4643
EI 1479-683X
J9 EUR J ENDOCRINOL
JI Eur. J. Endocrinol.
PD NOV
PY 2015
VL 173
IS 5
BP 665
EP 675
DI 10.1530/EJE-15-0450
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA CV1NU
UT WOS:000364025800017
PM 26311088
OA Bronze
DA 2025-06-11
ER

PT J
AU Kim, D
   Lee, JE
   Jung, YJ
   Lee, AS
   Lee, S
   Park, SK
   Kim, SH
   Park, BH
   Kim, W
   Kang, KP
AF Kim, Dal
   Lee, Jung Eun
   Jung, Yu Jin
   Lee, Ae Sin
   Lee, Sik
   Park, Sung Kwang
   Kim, Suhn Hee
   Park, Byung-Hyun
   Kim, Won
   Kang, Kyung Pyo
TI Metformin decreases high-fat diet-induced renal injury by regulating the
   expression of adipokines and the renal AMP-activated protein
   kinase/acetyl-CoA carboxylase pathway in mice
SO INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
LA English
DT Article
DE obesity; renal injury; insulin resistance; adipokine; AMP-activated
   protein kinase
ID CHRONIC KIDNEY-DISEASE; METABOLIC SYNDROME; INSULIN-RESISTANCE; KINASE;
   ADIPONECTIN; MECHANISMS; INITIATION; THERAPY; OBESITY; IMPACT
AB Metabolic syndrome is characterized by insulin resistance, dyslipidemia and hypertension. These metabolic changes contribute to the development of obesity-induced kidney injury. AMP-activated protein kinase (AMPK) is a ubiquitous enzyme that is involved in the cellular metabolic response to metabolic stress. Metformin, an AMPK activator, has been reported to exert a protective effect against non-alcoholic steatohepatitis. However, little is known about its role in the pathogenesis of obesity-induced renal injury. The aim of this study was to investigate the effects of metformin on high-fat diet (HFD)-induced kidney injury. Obesity was induced by HFD (60% of total calories from fat, 20% protein and 20% carbohydrates) in 6-week-old C57BL/6 mice. Mice were fed HFD plus 0.5% metformin. The effects of metformin on HFD-induced renal injury were evaluated by determining metabolic parameters, serum adipokine levels and renal AMPK/acetyl-CoA carboxylase (ACC) activities, as well as a histological examination. HFD induced metabolic derangement, systemic insulin resistance and glomerular mesangial matrix expansion. The administration of metformin reduced HFD-induced metabolic derangement and renal injury. The administration of metformin reduced the HFD-induced increase in adipokine expression and macrophage infiltration. Moreover, renal AMPK activity, which was decreased by HFD, was recovered following the administration of metformin; in addition, fatty acid oxidation was increased by the inhibition of ACC. These results indicate that metformin exerts beneficial effects on obesity-induced renal injury by regulating systemic inflammation, insulin resistance and the renal AMPK/ACC pathway. The clinical application of metformin to obese or early diabetic patients may be helpful in preventing obesity- or diabetes-related kidney disease.
C1 [Kim, Dal; Lee, Jung Eun; Jung, Yu Jin; Lee, Ae Sin; Lee, Sik; Park, Sung Kwang; Kim, Won; Kang, Kyung Pyo] Chonbuk Natl Univ, Sch Med, Res Inst Clin Med, Dept Internal Med, Jeonju 561712, South Korea.
   [Kim, Dal; Lee, Jung Eun; Jung, Yu Jin; Lee, Ae Sin; Lee, Sik; Park, Sung Kwang; Park, Byung-Hyun; Kim, Won; Kang, Kyung Pyo] Chonbuk Natl Univ, Sch Med, Diabet Res Ctr, Jeonju 561712, South Korea.
   [Kim, Suhn Hee] Chonbuk Natl Univ, Sch Med, Dept Physiol & Diabet, Jeonju 561712, South Korea.
   [Park, Byung-Hyun] Chonbuk Natl Univ, Sch Med, Dept Biochem, Jeonju 561712, South Korea.
C3 Jeonbuk National University; Jeonbuk National University; Jeonbuk
   National University; Jeonbuk National University
RP Kang, KP (corresponding author), Chonbuk Natl Univ, Sch Med, Res Inst Clin Med, Dept Internal Med, 20 Geonjiro, Jeonju 561712, South Korea.
EM kpkang@chonbuk.ac.kr
RI Lee, Jung-Seok/L-6826-2019; Kim, Tae/B-9921-2013; Kang, Kyung
   Pyo/ABG-3614-2020; Kim, Won/F-1643-2018
OI KIM, DAL/0000-0002-4411-2755; Kang, Kyung Pyo/0000-0001-8720-9701
FU National Research Foundation of Korea (NRF); Korean government
   [2012R1A1A4A01010065, 2012-0009322]
FX The present study was supported by the National Research Foundation of
   Korea (NRF) funded by the Korean government (2012R1A1A4A01010065 and
   2012-0009322, to K.P.K).
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NR 34
TC 44
Z9 50
U1 0
U2 14
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1107-3756
EI 1791-244X
J9 INT J MOL MED
JI Int. J. Mol. Med.
PD DEC
PY 2013
VL 32
IS 6
BP 1293
EP 1302
DI 10.3892/ijmm.2013.1508
PG 10
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 296ZV
UT WOS:000330225300009
PM 24068196
OA Bronze
DA 2025-06-11
ER

PT J
AU Nordfjall, K
   Eliasson, M
   Stegmayr, B
   Lundin, S
   Roos, G
   Nilsson, PM
AF Nordfjall, K.
   Eliasson, M.
   Stegmayr, B.
   Lundin, S.
   Roos, G.
   Nilsson, P. M.
TI Increased abdominal obesity, adverse psychosocial factors and shorter
   telomere length in subjects reporting early ageing; the MONICA Northern
   Sweden Study
SO SCANDINAVIAN JOURNAL OF PUBLIC HEALTH
LA English
DT Article
DE ageing; metabolic syndrome; self-perceived; smoking; social; telomere
   length
ID SELF-RATED HEALTH; CARDIOVASCULAR-DISEASE; RISK-FACTORS; MORTALITY; AGE;
   GENDER; STRESS; DETERMINANTS; LINK
AB Background: The rate of biological ageing is individual and represents the steady decrease in physiological and mental functions. Adverse social factors have been shown to influence this process. Self-perceived early ageing (SEA) might be a useful indicator of early biological ageing and increased mortality risk. The aim of this population-based study was to identify markers of SEA, including telomere length. Methods: We studied 1502 subjects (744 men, 758 women) from Northern Sweden. These subjects underwent a physical examination, blood sampling (including telomere length) and completed a self-administered questionnaire about their subjective age, social situation, lifestyle, and self-rated health (SRH). Age- and SRH-adjusted statistical analyses were made comparing SEA subjects with same-sex controls. Results: In all, 7.9% of men and 12.1% of women reported SEA. These subjects had significantly (p < 0.0001) wider waist circumference and higher body mass index than controls. SEA men showed higher fasting glucose and SEA women showed higher total cholesterol levels than controls (p=0.020 and p=0.015, respectively). In addition, SEA women more often reported infrequent physical exercise (p=0.006), mental problems (p=0.064) and worse SRH (p=0.001) than controls. In a random sub-sample, telomere length was significantly shorter in SEA subjects (n=139) than controls (n=301; p=0.02), but not after full adjustment for BMI. Conclusions: Self-perceived early ageing is not uncommon and is associated with abdominal obesity, poor self-rated health, lower education, and shorter telomere length. This could link adverse social factors with features of the metabolic syndrome as well as with early biological ageing, of importance for targeting preventive programmes.
C1 [Lundin, S.; Nilsson, P. M.] Univ Hosp, Dept Clin Sci Med, S-20502 Malmo, Sweden.
   [Nordfjall, K.; Roos, G.] Umea Univ, Dept Med Biosci Pathol, Umea, Sweden.
   [Eliasson, M.] Sunderbyn Hosp, Dept Med, Lulea, Sweden.
   [Stegmayr, B.] Umea Univ, Dept Publ Hlth & Clin Med, Umea, Sweden.
C3 Lund University; Skane University Hospital; Umea University; Sunderby
   Hospital; Umea University
RP Nilsson, PM (corresponding author), Univ Hosp, Dept Clin Sci Med, S-20502 Malmo, Sweden.
EM Peter.Nilsson@med.lu.se
OI Venkatasubramanian, Siddharth/0000-0002-5860-0768
FU Swedish Research Council; Research Council for Social Sciences; Heart
   and Lung Fund; King Gustaf V's and Queen Victoria's Foundation;
   Vasterbotten and Norrbotten County Councils; European Union
   [LSHC-CT-2004-502943]; Swedish Medical Research Council [345-2003-2461];
   Umea University
FX We thank the staff working with the Northern Sweden MONICA Project,
   including the surveys. This study was supported by grants from the
   Swedish Research Council, the Research Council for Social Sciences, the
   Heart and Lung Fund, King Gustaf V's and Queen Victoria's Foundation,
   the Vasterbotten and Norrbotten County Councils (including ''Visare
   Norr'') and by grant LSHC-CT-2004-502943 Mol Cancer Med from the
   European Union. Dr. Stegmayr is supported by a grant from the Swedish
   Medical Research Council (Project 345-2003-2461), Umea University.
   Senior statistician Jan-Ake Nilsson, Malmo, has kindly reviewed the
   statistical analyses.
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NR 41
TC 41
Z9 43
U1 0
U2 6
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1403-4948
EI 1651-1905
J9 SCAND J PUBLIC HEALT
JI Scand. J. Public Health
PD SEP
PY 2008
VL 36
IS 7
BP 744
EP 752
DI 10.1177/1403494808090634
PG 9
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA 348TB
UT WOS:000259231900011
PM 18647789
DA 2025-06-11
ER

PT J
AU Fwu, CW
   Schulman, IH
   Lawrence, JM
   Kimmel, PL
   Eggers, P
   Norton, J
   Chan, KV
   Mendley, SR
   Barthold, JS
AF Fwu, Chyng-Wen
   Schulman, Ivonne H.
   Lawrence, Jean M.
   Kimmel, Paul L.
   Eggers, Paul
   Norton, Jenna
   Chan, Kevin
   Mendley, Susan R.
   Barthold, Julia S.
TI Association of Obesity, Metabolic Syndrome, and Diabetes With Urinary
   Incontinence and Chronic Kidney Disease: Analysis of the National Health
   and Nutrition Examination Survey, 2003-2020
SO JOURNAL OF UROLOGY
LA English
DT Article
DE urinary incontinence; chronic kidney disease; obesity; metabolic
   disease; diabetes
ID TRACT SYMPTOMS; RISK-FACTORS; PREVALENCE; WOMEN; POPULATION; MANAGEMENT;
   COMPONENTS; IMPACT
AB Purpose:Diabetes and obesity, components of the metabolic syndrome (MetS), are risk factors for urinary incontinence (UI) and chronic kidney disease (CKD). We interrogated US population-based data to explore independent, sex-specific associations between nondiabetic MetS, with and without obesity, and UI and/or CKD.Materials and Methods:We analyzed data from 8586 males and 8420 females >= 20 years from the National Health and Nutrition Examination Survey. Multivariable logistic regression models were used to examine associations of UI or CKD with diabetes and 4 nondiabetic obesity/metabolic phenotypes: non-MetS/nonobese, MetS/nonobese, non-MetS/obese, and MetS/obese. Multinominal logistic regression models were used to assess associations of co-occurring UI/CKD with obesity/metabolic phenotypes.Results:Male MetS/obese participants had increased odds of any UI (1.25; 95% CI 1.00-1.57) and urgency UI (1.36; 1.03-1.80), compared with non-MetS/nonobese participants. Female MetS/obese participants had increased odds of any UI (2.16; 95% CI 1.76-2.66), stress UI (1.51; 1.21-1.87), and mixed UI (1.66; 1.31-2.11) compared with non-MetS/nonobese participants. The odds of co-occurring UI/CKD were increased relative to either condition alone in persons with diabetes, and in males with MetS/obese phenotypes and females with MetS phenotypes as compared to same sex participants with neither obesity nor MetS.Conclusions:We found novel associations between MetS/obese and urgency UI in males without diabetes, and between SUI and both MetS and obesity in females without diabetes. Odds estimates for UI/CKD were increased by existing obesity or MetS as compared to those for UI or CKD alone. Improved understanding of modifiable factors associated with UI will inform prevention and treatment opportunities.
C1 [Fwu, Chyng-Wen] Social & Sci Syst Inc, Silver Spring, MD USA.
   [Schulman, Ivonne H.; Kimmel, Paul L.; Eggers, Paul; Norton, Jenna; Chan, Kevin; Mendley, Susan R.; Barthold, Julia S.] NIDDKD, Div Kidney Urol & Hematol Dis, NIH, Two Democracy Plaza,Room 6081,6707 Democracy Blvd, Bethesda, MD 20892 USA.
   [Lawrence, Jean M.] NIDDKD, Div Diabet Endocrinol & Metab Dis, NIH, Bethesda, MD 20892 USA.
C3 Social & Scientific Systems; National Institutes of Health (NIH) - USA;
   NIH National Institute of Diabetes & Digestive & Kidney Diseases
   (NIDDK); National Institutes of Health (NIH) - USA; NIH National
   Institute of Diabetes & Digestive & Kidney Diseases (NIDDK)
RP Barthold, JS (corresponding author), NIDDKD, Div Kidney Urol & Hematol Dis, NIH, Two Democracy Plaza,Room 6081,6707 Democracy Blvd, Bethesda, MD 20892 USA.
EM chyng-wen.fwu@dlhcorp.com; ivonne.schulman@nih.gov;
   jean.lawrence@nih.gov; kimmelp@extra.niddk.nih.gov; paul.eggers@nih.gov;
   jenna.norton@nih.gov; kevin.chan2@nih.gov; susan.mendley@nih.gov;
   julia.barthold@gmail.com
RI Schulman, Ivonne/K-6436-2019; Chan, Kevin/JQI-6002-2023
FU National Institute of Diabetes and Digestive and Kidney Diseases
FX No Statement Available
CR Abufaraj M, 2021, AM J OBSTET GYNECOL, V225, DOI 10.1016/j.ajog.2021.03.016
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NR 31
TC 14
Z9 14
U1 8
U2 16
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0022-5347
EI 1527-3792
J9 J UROLOGY
JI J. Urol.
PD JAN
PY 2024
VL 211
IS 1
BP 124
EP 133
DI 10.1097/JU.0000000000003761
PG 10
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA CK7W0
UT WOS:001125221300051
PM 37862455
DA 2025-06-11
ER

PT J
AU Farahani, RA
   Zhu, XY
   Tang, H
   Jordan, KL
   Lerman, A
   Lerman, LO
   Eirin, A
AF Farahani, Rahele A.
   Zhu, Xiang-Yang
   Tang, Hui
   Jordan, Kyra L.
   Lerman, Amir
   Lerman, Lilach O.
   Eirin, Alfonso
TI Metabolic Syndrome Alters the Cargo of Mitochondria-Related microRNAs in
   Swine Mesenchymal Stem Cell-Derived Extracellular Vesicles, Impairing
   Their Capacity to Repair the Stenotic Kidney
SO STEM CELLS INTERNATIONAL
LA English
DT Article
ID GLOMERULAR-FILTRATION-RATE; RESTORE RENAL-FUNCTION; RENOVASCULAR
   DISEASE; ANALYSIS PIPELINE; REVASCULARIZATION; PERFUSION; INFLAMMATION;
   PREVALENCE; BIOMARKERS; OUTCOMES
AB Background. Coexisting metabolic syndrome (MetS) and renal artery stenosis (RAS) are linked to poor renal outcomes. Mesenchymal stem/stromal cell- (MSC-) derived extracellular vesicles (EVs) from lean animals show superior ability to repair the experimental MetS+RAS kidney compared to EVs from MetS pig MSCs. We hypothesized that MetS leads to selective packaging in porcine EVs of microRNAs capable of targeting mitochondrial genes, interfering with their capacity to repair the MetS+RAS kidney. Methods. Five groups of pigs (n=7 each) were studied after 16 weeks of diet-induced MetS and RAS (MetS+RAS) and MetS+RAS 4 weeks after a single intrarenal delivery of EVs harvested from allogeneic adipose tissue-derived MSCs isolated from Lean or MetS pigs, and Lean or MetS sham controls. Single-kidney blood flow (RBF) and glomerular filtration rate (GFR) were assessed in vivo with multidetector CT, whereas EV microRNA cargo, renal tubular mitochondrial structure and bioenergetics, and renal injury pathways were assessed ex vivo. Results. microRNA sequencing revealed 19 dysregulated microRNAs capable of targeting several mitochondrial genes in MetS-EVs versus Lean-EVs. Lean- and MetS-EVs were detected in the stenotic kidney 4 weeks after administration. However, only MetS-EVs failed to improve renal mitochondrial density, structure, and function or attenuate oxidative stress, tubular injury, and fibrosis. Furthermore, Lean-EVs but not MetS-EVs restored RBF and GFR in MetS+RAS. Conclusion. MetS alters the cargo of mitochondria-related microRNAs in swine MSC-derived EVs, which might impair their capacity to repair the poststenotic kidney in MetS+RAS. These observations may contribute to develop approaches to improve the efficacy of MSC-EVs for patients with MetS.
C1 [Farahani, Rahele A.; Zhu, Xiang-Yang; Tang, Hui; Jordan, Kyra L.; Lerman, Lilach O.; Eirin, Alfonso] Mayo Clin, Div Nephrol & Hypertens, Dept Internal Med, Rochester, MN 55905 USA.
   [Lerman, Amir] Mayo Clin, Dept Cardiovasc Dis, Rochester, MN USA.
C3 Mayo Clinic; Mayo Clinic
RP Eirin, A (corresponding author), Mayo Clin, Div Nephrol & Hypertens, Dept Internal Med, Rochester, MN 55905 USA.
EM eirinmassat.alfonso@mayo.edu
RI Lerman, Lilach/M-4962-2017; Eirin, Alfonso/N-9873-2013
OI Eirin, Alfonso/0000-0002-3864-9644
FU NIH [DK106427, DK122137, DK122734, DK120292, DK102325]
FX This work was supported by the NIH grants: DK106427, DK122137, DK122734,
   DK120292, and DK102325.
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NR 66
TC 14
Z9 14
U1 0
U2 1
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1687-966X
EI 1687-9678
J9 STEM CELLS INT
JI Stem Cells Int.
PD NOV 17
PY 2020
VL 2020
AR 8845635
DI 10.1155/2020/8845635
PG 15
WC Cell & Tissue Engineering
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA PD0AL
UT WOS:000597357900001
PM 33281903
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Dusanov, S
   Heggen, E
   Tonstad, S
AF Dusanov, Sasa
   Heggen, Eli
   Tonstad, Serena
TI Characteristics of Metabolic Syndrome in Morbidly Obese Subjects
SO METABOLIC SYNDROME AND RELATED DISORDERS
LA English
DT Article
ID INSULIN-RESISTANCE; FAT MASS; HEALTHY; WOMEN; DYSLIPIDEMIA;
   INFLAMMATION; INDIVIDUALS; DISORDERS; LIVER; RISK
AB Background: Metabolic syndrome (MetSyn) magnifies risks of cardiovascular disease (CVD) and type 2 diabetes, but its expression varies within the obese population. We examined body mass index (BMI), metabolic traits, and fat distribution in morbidly obese individuals. Methods: Lipids and inflammatory, oxidative stress and hepatic biomarkers in 346 women and 203 men (BMI 35kg/m(2) and co-morbidity or 40kg/m(2)) were stratified by MetSyn components (1-5, excluding diabetes). Age- and smoking-adjusted partial correlations were calculated. Dual-energy X-ray absorptiometry was measured in 206 participants. Results: Apolipoprotein B, ferritin, uric acid, and alanine aminotransferase (ALT) concentrations worsened with increasing MetSyn components (P0.0001), while BMI and LDL-cholesterol showed no association. BMI correlated inversely with triglycerides (r=-0.16, P=0.03) and positively with HDL-cholesterol in men (r=0.16, P=0.02), but not in women. BMI correlated with C-reactive protein (CRP) (r=0.32, P<0.0001; r=0.24, P<0.0001 in men and women, respectively) and white blood cell count (r=0.24, P=0.001 in men; r=0.15, P=0.008 in women). Truncal fat percentage correlated to CRP (r=0.31, P=0.03; r=0.20, P=0.02 in men and women, respectively). In women, number of MetSyn components was inversely related to truncal and peripheral fat (r=-0.20, P=0.02; r=-0.42, P<0.0001, respectively) as was ALT (r=-0.21, P=0.009; r=-0.38, P<0.0001, respectively) and triglycerides with peripheral fat (r=-0.38, P<0.0001), while HDL cholesterol was positively associated with truncal and peripheral fat (r=0.26; P=0.001). Conclusions: BMI and fat distribution showed expected associations to inflammation biomarkers, but paradoxical relations between fat indices, and MetSyn components and biomarkers were seen. This suggests a need for better markers of CVD risk in morbid obesity.
C1 [Dusanov, Sasa; Heggen, Eli; Tonstad, Serena] Oslo Univ Hosp, Dept Endocrinol Morbid Obes & Prevent Med, Sect Prevent Cardiol, Pb 4956 Nydalen, N-0424 Oslo, Norway.
C3 University of Oslo
RP Dusanov, S (corresponding author), Oslo Univ Hosp, Dept Endocrinol Morbid Obes & Prevent Med, Sect Prevent Cardiol, Pb 4956 Nydalen, N-0424 Oslo, Norway.
EM sasdus@ous-hf.no
CR Aasen G, 2009, SCAND J CLIN LAB INV, V69, P181, DOI 10.1080/00365510802464641
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NR 23
TC 5
Z9 5
U1 0
U2 3
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-4196
EI 1557-8518
J9 METAB SYNDR RELAT D
JI Metab. Syndr. Relat. Disord.
PD DEC
PY 2016
VL 14
IS 10
BP 500
EP 506
DI 10.1089/met.2016.0062
PG 7
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA EF3RJ
UT WOS:000390241800006
PM 27513810
DA 2025-06-11
ER

PT J
AU Softic, S
   Cohen, DE
   Kahn, CR
AF Softic, Samir
   Cohen, David E.
   Kahn, C. Ronald
TI Role of Dietary Fructose and Hepatic De Novo Lipogenesis in Fatty Liver
   Disease
SO DIGESTIVE DISEASES AND SCIENCES
LA English
DT Review
DE NAFLD; NASH; Fructose; HFD; Metabolism; De novo lipogenesis; Liver
ID STEAROYL-COA DESATURASE-1; ATP-CITRATE-LYASE; SUGAR-SWEETENED BEVERAGES;
   ANTISENSE OLIGONUCLEOTIDE INHIBITORS; INSULIN-RESISTANCE; METABOLIC
   SYNDROME; NONALCOHOLIC STEATOHEPATITIS; URIC-ACID; HIGH-CARBOHYDRATE;
   UNITED-STATES
AB Nonalcoholic fatty liver disease (NAFLD) is a liver manifestation of metabolic syndrome. Overconsumption of high-fat diet (HFD) and increased intake of sugar-sweetened beverages are major risk factors for development of NAFLD. Today the most commonly consumed sugar is high fructose corn syrup. Hepatic lipids may be derived from dietary intake, esterification of plasma free fatty acids (FFA) or hepatic de novo lipogenesis (DNL). A central abnormality in NAFLD is enhanced DNL. Hepatic DNL is increased in individuals with NAFLD, while the contribution of dietary fat and plasma FFA to hepatic lipids is not significantly altered. The importance of DNL in NAFLD is further established in mouse studies with knockout of genes involved in this process. Dietary fructose increases levels of enzymes involved in DNL even more strongly than HFD. Several properties of fructose metabolism make it particularly lipogenic. Fructose is absorbed via portal vein and delivered to the liver in much higher concentrations as compared to other tissues. Fructose increases protein levels of all DNL enzymes during its conversion into triglycerides. Additionally, fructose supports lipogenesis in the setting of insulin resistance as fructose does not require insulin for its metabolism, and it directly stimulates SREBP1c, a major transcriptional regulator of DNL. Fructose also leads to ATP depletion and suppression of mitochondrial fatty acid oxidation, resulting in increased production of reactive oxygen species. Furthermore, fructose promotes ER stress and uric acid formation, additional insulin independent pathways leading to DNL. In summary, fructose metabolism supports DNL more strongly than HFD and hepatic DNL is a central abnormality in NAFLD. Disrupting fructose metabolism in the liver may provide a new therapeutic option for the treatment of NAFLD.
C1 [Softic, Samir; Kahn, C. Ronald] Joslin Diabet Ctr, Sect Integrat Physiol & Metab, 1 Joslin Pl, Boston, MA 02215 USA.
   [Softic, Samir] Boston Childrens Hosp, Dept Gastroenterol Hepatol & Nutr, Boston, MA USA.
   [Cohen, David E.] Harvard Univ, Brigham & Womens Hosp, Sch Med, Div Gastroenterol,Dept Med, Boston, MA 02115 USA.
C3 Harvard University; Harvard University Medical Affiliates; Joslin
   Diabetes Center, Inc.; Harvard University; Harvard University Medical
   Affiliates; Boston Children's Hospital; Harvard University; Harvard
   University Medical Affiliates; Brigham & Women's Hospital; Harvard
   Medical School
RP Kahn, CR (corresponding author), Joslin Diabet Ctr, Sect Integrat Physiol & Metab, 1 Joslin Pl, Boston, MA 02215 USA.
EM c.ronald.kahn@joslin.harvard.edu
RI Softic, Samir/ABD-4612-2020; Kahn, Ronald/AAY-2435-2021
OI Softic, Samir/0000-0003-1419-9789
FU NIH [R01 DK031036, R01 DK033201, R37 DK048873, R01 DK056626, R01
   DK103046, K12 HD000850]
FX This work was supported in part by NIH Grants R01 DK031036 and R01
   DK033201 to C.R.K, R37 DK048873, R01 DK056626, and R01 DK103046 to
   D.E.C, and K12 HD000850 to S.S.
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NR 130
TC 484
Z9 524
U1 11
U2 179
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0163-2116
EI 1573-2568
J9 DIGEST DIS SCI
JI Dig. Dis. Sci.
PD MAY
PY 2016
VL 61
IS 5
SI SI
BP 1282
EP 1293
DI 10.1007/s10620-016-4054-0
PG 12
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA DK1JH
UT WOS:000374667800007
PM 26856717
OA Green Accepted
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Xu, LS
   Hu, GZ
   Qiu, JH
   Miura, T
   Yamakoshi, S
   Namai-takahashi, A
   Kohzuki, M
   Ito, O
AF Xu, Lusi
   Hu, Gaizun
   Qiu, Jiahe
   Miura, Takahiro
   Yamakoshi, Seiko
   Namai-takahashi, Asako
   Kohzuki, Masahiro
   Ito, Osamu
TI Exercise Training Prevents High Fructose-Induced Hypertension and Renal
   Damages in Male Dahl Salt-Sensitive Rats
SO MEDICINE & SCIENCE IN SPORTS & EXERCISE
LA English
DT Article
DE HIGH-FRUCTOSE DIET; EXERCISE TRAINING; DAHL SALT-SENSITIVE RATS; RENAL
   DAMAGE; RENIN-ANGIOTENSIN SYSTEM
ID RENIN-ANGIOTENSIN SYSTEM; BLOOD-PRESSURE; GLOMERULAR HYPERTENSION;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; OXIDATIVE STRESS; UP-REGULATION;
   ACID; KIDNEY; ATTENUATION
AB IntroductionHigh-fructose diet (HFr) causes metabolic syndrome, and HFr-induced hypertension and renal damage are exaggerated in Dahl salt-sensitive (DS) rats. Exercise training (Ex) has antihypertensive and renal protective effects in rats fed HFr; however, there has been little discussion about the DS rats, which exhibit metabolic disturbances. This study thus examined the effects of Ex on DS rats fed HFr.MethodsMale DS rats were divided into three groups. The control group was fed a control diet, and both the HFr group and the HFr-Ex group were fed an HFr (60% fructose). The HFr-Ex group also underwent treadmill running (20 m & BULL;min(-1), 60 min & BULL;d(-1), 5 d & BULL;wk(-1)). After 12 wk, renal function, histology, and renin-angiotensin system were examined.ResultsHFr increased blood pressure, urinary albumin, and creatinine clearance, and Ex inhibited these increases. HFr induced glomerular sclerosis, podocyte injury, afferent arteriole thickening, and renal interstitial fibrosis, and Ex ameliorated them. HFr reduced plasma renin activity, and Ex further reduced the activity. HFr also increased the expression of angiotensinogen, renin, angiotensin-converting enzyme (ACE), and angiotensin II type 1 receptor, and Ex restored the ACE expression to the control levels. HFr decreased the expression of ACE2, angiotensin II type 2 receptor, and Mas receptor, and Ex restored the ACE2 and Mas receptor expressions to the control levels and further decreased the angiotensin II type 2 receptor expression. HFr increased the ACE activity and decreased the ACE2 activity, and Ex restored these activities to the control levels.ConclusionsEx prevents HFr-induced hypertension and renal damages in DS rats. The changes in renal renin-angiotensin system may be involved in the mechanism of the antihypertensive and renal protective effects of Ex.
C1 [Xu, Lusi; Namai-takahashi, Asako; Ito, Osamu] Tohoku Med & Pharmaceut Univ, Fac Med, Div Gen Med & Rehabil, Sendai, Japan.
   [Xu, Lusi; Qiu, Jiahe; Miura, Takahiro; Yamakoshi, Seiko; Kohzuki, Masahiro] Tohoku Univ, Dept Internal Med & Rehabil Sci, Grad Sch Med, Sendai, Japan.
   [Hu, Gaizun] Univ Virginia, Sch Med, Dept Mol Physiol & Biol Phys, Charlottesville, VA USA.
   [Yamakoshi, Seiko] Tohoku Med & Pharmaceut Univ, Fac Med, Div Nephrol & Endocrinol, Sendai, Japan.
   [Ito, Osamu] Tohoku Med & Pharmaceut Univ, Fac Med, Div Gen Med & Rehabil, 1-15-1 Fukumuro Miyagino Ku, Sendai 9838536, Japan.
C3 Tohoku Medical & Pharmaceutical University; Tohoku University;
   University of Virginia; Tohoku Medical & Pharmaceutical University;
   Tohoku Medical & Pharmaceutical University
RP Ito, O (corresponding author), Tohoku Med & Pharmaceut Univ, Fac Med, Div Gen Med & Rehabil, 1-15-1 Fukumuro Miyagino Ku, Sendai 9838536, Japan.
EM jyolx@yahoo.co.jp; guinsooh@gmail.com; jiaheeqiu@gmail.com;
   takamiur@gmail.com; seicouleur@gmail.com; hemp_nama@icloud.com;
   kohzuki@med.tohoku.ac.jp; oito@hosp.tohoku-mpu.ac.jp
RI Miura, Takahiro/ACV-4988-2022
OI Qiu, Jiahe/0000-0002-9716-4890
FU Japan Society for the Promotion of Science [17H02119, 20H04054, 22
   K17656]; Grants-in-Aid for Scientific Research [20H04034, 20H04054,
   20K19338, 23K27939, 22K17656] Funding Source: KAKEN
FX This work was supported by Grants-in-Aid for Scientific Research from
   Japan Society for the Promotion of Science grants 17H02119, 20H04054,
   and 22 K17656. The authors declare that they have no conflict of
   interests. The results of the study are presented clearly, honestly, and
   without fabrication or inappropriate data manipulation. The results of
   the present study do not constitute endorsement by the American College
   of Sports Medicine.
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NR 42
TC 5
Z9 5
U1 0
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0195-9131
EI 1530-0315
J9 MED SCI SPORT EXER
JI Med. Sci. Sports Exerc.
PD MAY
PY 2023
VL 55
IS 5
BP 803
EP 812
DI 10.1249/MSS.0000000000003100
PG 10
WC Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Sport Sciences
GA P7EB1
UT WOS:001052257200005
PM 36729699
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Greenstein, AS
   Khavandi, K
   Withers, SB
   Sonoyama, K
   Clancy, O
   Jeziorska, M
   Laing, I
   Yates, AP
   Pemberton, PW
   Malik, RA
   Heagerty, AM
AF Greenstein, Adam S.
   Khavandi, Kaivan
   Withers, Sarah B.
   Sonoyama, Kazuhiko
   Clancy, Olivia
   Jeziorska, Maria
   Laing, Ian
   Yates, Allen P.
   Pemberton, Philip W.
   Malik, Rayaz A.
   Heagerty, Anthony M.
TI Local Inflammation and Hypoxia Abolish the Protective Anticontractile
   Properties of Perivascular Fat in Obese Patients
SO CIRCULATION
LA English
DT Article
DE hypoxia; inflammation; obesity; microcirculation; nitric oxide synthase
ID TUMOR-NECROSIS-FACTOR; PERIADVENTITIAL ADIPOSE-TISSUE; METABOLIC
   SYNDROME; FACTOR-ALPHA; INSULIN-RESISTANCE; VASCULAR FUNCTION; HUMAN
   ADIPOCYTES; FACTOR RECEPTORS; EXPRESSION; ADIPONECTIN
AB Background-Inflammation in adipose tissue has been implicated in vascular dysfunction, but the local mechanisms by which this occurs are unknown.
   Methods and Results-Small arteries with and without perivascular adipose tissue were taken from subcutaneous gluteal fat biopsy samples and studied with wire myography and immunohistochemistry. We established that healthy adipose tissue around human small arteries secretes factors that influence vasodilation by increasing nitric oxide bioavailability. However, in perivascular fat from obese subjects with metabolic syndrome (waist circumference 111+/-2.8 versus 91.1+/-3.5 cm in control subjects, P<0.001; insulin sensitivity 41+/-5.9% versus 121+/-18.6% in control subjects, P<0.001), the loss of this dilator effect was accompanied by an increase in adipocyte area (1786+/-346 versus 673+/-60 mu m(2), P<0.01) and immunohistochemical evidence of inflammation (tumor necrosis factor receptor 1 12.4+/-1.1% versus 6.7+/-1%, P<0.001). Application of the cytokines tumor necrosis factor receptor-alpha and interleukin-6 to perivascular fat around healthy blood vessels reduced dilator activity, resulting in the obese phenotype. These effects could be reversed with free radical scavengers or cytokine antagonists. Similarly, induction of hypoxia stimulated inflammation and resulted in loss of anticontractile capacity, which could be rescued by catalase and superoxide dismutase or cytokine antagonists. Incubation with a soluble fragment of adiponectin type 1 receptor or inhibition of nitric oxide synthase blocked the vasodilator effect of healthy perivascular adipose tissue.
   Conclusions-We conclude that adipocytes secrete adiponectin and provide the first functional evidence that it is a physiological modulator of local vascular tone by increasing nitric oxide bioavailability. This capacity is lost in obesity by the development of adipocyte hypertrophy, leading to hypoxia, inflammation, and oxidative stress. (Circulation. 2009; 119: 1661-1670.)
C1 [Heagerty, Anthony M.] Univ Manchester, Cardiovasc Res Grp, Core Technol Facil, Manchester M13 9NT, Lancs, England.
   [Jeziorska, Maria] Univ Manchester, Dept Regenerat Med Lab & Clin Sci, Manchester M13 9NT, Lancs, England.
   [Greenstein, Adam S.; Heagerty, Anthony M.] Wellcome Trust Clin Res Facil, Manchester, Lancs, England.
   [Laing, Ian; Yates, Allen P.; Pemberton, Philip W.] Manchester Royal Infirm, Dept Clin Biochem, Manchester M13 9WL, Lancs, England.
C3 University of Manchester; University of Manchester; University of
   Manchester; University of Manchester
RP Heagerty, AM (corresponding author), Univ Manchester, Cardiovasc Res Grp, Core Technol Facil, 46 Grafton St, Manchester M13 9NT, Lancs, England.
EM tony.heagerty@manchester.ac.uk
RI Malik, Rayaz/H-9231-2019; Yates, Allen/AAE-5071-2020; Jeziorska,
   Maria/P-1731-2015
OI Jeziorska, Maria/0000-0002-3492-0177; Greenstein,
   Adam/0000-0002-5274-4189; Withers, Sarah/0000-0002-7021-881X; Yates,
   Allen/0000-0001-5549-953X; Heagerty, Anthony/0000-0002-9043-2119; Malik,
   Rayaz/0000-0002-7188-8903
FU European Society of Hypertension; Wellcome Trust
FX This study was funded by the European Society of Hypertension and the
   Wellcome Trust. Dr Heagerty has received speaking honoraria from Pfizer,
   Bayer, and Daiichi Sankyo. Dr Malik has received speaking honoraria from
   Pfizer, Astra-Zeneca, and Lilly. Dr Greenstein is a European Society of
   Hypertension Research Fellow.
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NR 38
TC 496
Z9 537
U1 0
U2 26
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0009-7322
EI 1524-4539
J9 CIRCULATION
JI Circulation
PD MAR 31
PY 2009
VL 119
IS 12
BP 1661
EP U166
DI 10.1161/CIRCULATIONAHA.108.821181
PG 16
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 426LI
UT WOS:000264709400014
PM 19289637
OA Bronze
DA 2025-06-11
ER

PT J
AU Gharipour, M
   Kelishadi, R
   Sarrafzadegan, N
   Baghaei, A
   Yazdani, M
   Anaraki, J
   Eshrati, B
   Tavassoli, AA
AF Gharipour, Mojgan
   Kelishadi, Roya
   Sarrafzadegan, Nizal
   Baghaei, Abdolmehdi
   Yazdani, Mehrdad
   Anaraki, Jafar
   Eshrati, Babak
   Tavassoli, Ali-Akbar
TI The Association of Smoking with Components of the Metabolic Syndrome in
   Non-diabetic Patients
SO ANNALS ACADEMY OF MEDICINE SINGAPORE
LA English
DT Article
DE Anthropometric indexes; Biochemical factors
ID 3RD NATIONAL-HEALTH; ENDOTHELIAL DYSFUNCTION; PREVALENCE; MARKERS;
   SMOKERS; HABITS; STRESS
AB Introduction: There is limited evidence about the association between smoking and metabolic syndrome (MS). The aim of this study was to assess the association of smoking with MS components. Materials and Methods: As part of the baseline survey of a community-based study, we studied 5573 non-diabetic men. All participants were interviewed and underwent physical examinations and blood collection. Results: The study participants comprised 1625 smokers and 3948 non-smokers, with a mean age of 38.07 +/- 14.85 years. Serum low-density lipoprotein-cholesterol (LDL-C) and triglycerides (TG) were higher in smokers than in non-smokers (LDLC: 11534 +/- 39.03 vs 112.65 +/- 40.94 mg/dL, respectively, P = 0.015 and TG: 175.13 +/- 102.05 vs 172.32 +/- 116.83 mg/dL, respectively,P = 0.005). Body mass index, waist circumference and waisthip ratio were lower in smokers than in non-smokers. Mean systolic and diastolic blood pressures were significantly lower in smokers than in non-smokers (systolic: 112.06 +/- 15.888 vs 117.25 +/- 17.745 mmHg, respectively, P = 0.000; diastolic: 73.66 +/- 10.084 vs 76.23 +/- 10.458 mmHg, respectively, P = 0.000). The percentage of individuals with 2 MS components was higher in smokers than in non-smokers (39.64% vs 33.00%, respectively, P = 0.000). However, the percentage of non-smokers with 3 MS components was higher than in smokers (49.62% vs 43.82%, respectively, P = 0.000). Conclusions: Our findings support the hypothesis that lifestyle factors such as smoking can adversely affect MS components. However, we should acknowledge that these differences may have resulted from the large sample sires studied and may not be clinically significant. The lower prevalence of some MS components in smokers than in nonsmokers might be because of their lower anthropometric measures.
C1 [Gharipour, Mojgan] Isfahan Univ Med Sci, Isfahan Cardiovasc Res Ctr, Dept Biochem, Esfahan, Iran.
   [Baghaei, Abdolmehdi] Isfahan Univ Med Sci, Isfahan Cardiovasc Res Ctr, ARYA Atherosclerosis Journal, Esfahan, Iran.
   [Anaraki, Jafar] Isfahan Univ Med Sci, Isfahan Prov Hlth Off, Esfahan, Iran.
   [Eshrati, Babak] Arak Univ Med Sci, Arak, Iran.
C3 Isfahan University of Medical Sciences; Isfahan University of Medical
   Sciences; Isfahan University of Medical Sciences
RP Gharipour, M (corresponding author), Isfahan Univ Med Sci, Isfahan Cardiovasc Res Ctr, Dept Biochem, POB 81465-1148, Esfahan, Iran.
EM gharipour@crc.mui.ac.ir
RI Tavassoli, Aliakbar/W-5013-2017; Mohammadifard, Noushin/M-2244-2018;
   Gharipour, mojgan/R-3486-2019; Kelishadi, Roya/E-6154-2012;
   Sarrafzadegan, Nizal/V-5826-2017
OI Gharipour, Mojgan/0000-0001-7397-1172; Kelishadi,
   Roya/0000-0001-7455-1495; Sarrafzadegan, Nizal/0000-0002-8352-0540;
   Tavassoli, Aliakbar/0000-0001-9382-1403
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NR 26
TC 4
Z9 4
U1 0
U2 0
PU ACAD MEDICINE SINGAPORE
PI REPUBLIC SINGAPORE
PA 142 NEIL RD, REPUBLIC SINGAPORE 088871, SINGAPORE
SN 0304-4602
J9 ANN ACAD MED SINGAP
JI Ann. Acad. Med. Singap.
PD NOV
PY 2008
VL 37
IS 11
BP 919
EP 923
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 395BQ
UT WOS:000262497600005
PM 19082197
DA 2025-06-11
ER

PT J
AU Prather, AA
   Gurfein, B
   Moran, P
   Daubenmier, J
   Acree, M
   Bacchetti, P
   Sinclair, E
   Lin, J
   Blackburn, E
   Hecht, FM
   Epel, ES
AF Prather, Aric A.
   Gurfein, Blake
   Moran, Patricia
   Daubenmier, Jennifer
   Acree, Michael
   Bacchetti, Peter
   Sinclair, Elizabeth
   Lin, Jue
   Blackburn, Elizabeth
   Hecht, Frederick M.
   Epel, Elissa S.
TI Tired telomeres: Poor global sleep quality, perceived stress, and
   telomere length in immune cell subsets in obese men and women
SO BRAIN BEHAVIOR AND IMMUNITY
LA English
DT Article
DE Sleep quality; Sleep duration; Telomere length; Stress; Obesity
ID CARDIOVASCULAR-DISEASE; IN-VIVO; REPLICATIVE SENESCENCE; METABOLIC
   SYNDROME; OLDER-ADULTS; RISK-FACTORS; T-CELLS; DURATION; METAANALYSIS;
   ASSOCIATION
AB Poor sleep quality and short sleep duration are associated with increased incidence and progression of a number of chronic health conditions observed at greater frequency among the obese and those experiencing high levels of stress. Accelerated cellular aging, as indexed by telomere attrition in immune cells, is a plausible pathway linking sleep and disease risk. Prior studies linking sleep and telomere length are mixed. One factor may be reliance on leukocytes, which are composed of varied immune cell types, as the sole measure of telomere length. To better clarify these associations, we investigated the relationships of global sleep quality, measured by the Pittsburgh Sleep Quality Index (PSQI), and diary-reported sleep duration with telomere length in different immune cell subsets, including granulocytes, peripheral blood mononuclear cells (PBMCs), CD8+ and CD4+ T lymphocytes, and B lymphocytes in a sample of 87 obese men and women (BMI mean = 35.4, SD = 3.6; 81.6% women; 62.8% Caucasian). Multiple linear regression analyses were performed adjusting for age, gender, race, education, BMI, sleep apnea risk, and perceived stress. Poorer PSQI global sleep quality was associated with statistically significantly shorter telomere length in lymphocytes but not granulocytes and in particular CD8+ T cells (b = -56.8 base pairs per one point increase in PSQI, SE = 20.4, p = 0.007) and CD4+ T cells (b = -37.2, SE = 15.9, p = 0.022). Among separate aspects of global sleep quality, low perceived sleep quality and decrements in daytime function were most related to shorter telomeres. In addition, perceived stress moderated the sleep-CD8+ telomere association. Poorer global sleep quality predicted shorter telomere length in CD8+ T cells among those with high perceived stress but not in low stress participants. These findings provide preliminary evidence that poorer global sleep quality is related to telomere length in several immune cell types, which may serve as a pathway linking sleep and disease risk in obese individuals. (C) 2014 Elsevier Inc. All rights reserved.
C1 [Prather, Aric A.; Epel, Elissa S.] Univ Calif San Francisco, Dept Psychiat, San Francisco, CA 94118 USA.
   [Gurfein, Blake; Moran, Patricia; Daubenmier, Jennifer; Acree, Michael; Hecht, Frederick M.] Univ Calif San Francisco, Osher Ctr Integrat Med, Dept Med, San Francisco, CA 94118 USA.
   [Bacchetti, Peter] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94118 USA.
   [Sinclair, Elizabeth] Univ Calif San Francisco, Dept Med, San Francisco, CA 94118 USA.
   [Lin, Jue; Blackburn, Elizabeth] Univ Calif San Francisco, Dept Biochem & Biophys, San Francisco, CA 94118 USA.
C3 University of California System; University of California San Francisco;
   University of California System; University of California San Francisco;
   University of California System; University of California San Francisco;
   University of California System; University of California San Francisco;
   University of California System; University of California San Francisco
RP Prather, AA (corresponding author), Univ Calif San Francisco, Dept Psychiat, 3333 Calif St,Suite 465, San Francisco, CA 94118 USA.
EM aric.prather@ucsf.edu; eepel@Ippi.ucsf.edu
RI Hancq, Elizabeth/LRT-3695-2024; Epel, Elissa/ABI-6703-2022
OI Hecht, Frederick/0000-0002-5782-1171
FU NIH/NHLBI [K08HL112961]; NIH/NCCAM [P01AT005013, K24 AT007827]; National
   Center for Complementary and Integrative Health [K24AT007827] Funding
   Source: NIH RePORTER; National Heart Lung and Blood Institute; National
   Institute of Allergy and Infectious Diseases; National Institute on
   Minority Health and Health Disparities; Eunice Kennedy Shriver National
   Institute of Child Health and Human Development; National Cancer
   Institute [P30AI027763] Funding Source: NIH RePORTER; National Institute
   of Nursing Research; National Institute on Drug Abuse; National
   Institute of Diabetes and Digestive and Kidney Diseases; National
   Institute of Dental and Craniofacial Research; National Institute on
   Aging [P30AI027763] Funding Source: NIH RePORTER
FX This research was supported in part by a NIH/NHLBI grant K08HL112961 to
   Dr. Prather and NIH/NCCAM grants P01AT005013 and K24 AT007827 to Dr.
   Hecht.
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NR 69
TC 58
Z9 65
U1 0
U2 30
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0889-1591
EI 1090-2139
J9 BRAIN BEHAV IMMUN
JI Brain Behav. Immun.
PD JUL
PY 2015
VL 47
SI SI
BP 155
EP 162
DI 10.1016/j.bbi.2014.12.011
PG 8
WC Immunology; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Immunology; Neurosciences & Neurology; Psychiatry
GA CL8NM
UT WOS:000357231400018
PM 25535858
OA Green Accepted, Green Published
DA 2025-06-11
ER

PT J
AU Keirns, BH
   Hart, SM
   Sciarrillo, CM
   Poindexter, KL
   Clarke, SL
   Emerson, SR
AF Keirns, Bryant H.
   Hart, Samantha M.
   Sciarrillo, Christina M.
   Poindexter, Kara L.
   Clarke, Stephen L.
   Emerson, Sam R.
TI Postprandial triglycerides, endothelial function, and inflammatory
   cytokines as potential candidates for early risk detection in
   normal-weight obesity
SO OBESITY RESEARCH & CLINICAL PRACTICE
LA English
DT Article
DE Normal-weight obesity; Postprandial triglycerides; Endothelial function;
   Inflammation; Metabolic syndrome; Cardiovascular disease
ID OXIDATIVE STRESS; METABOLIC SYNDROME; LIPEMIA; ADULTS; MEAL
AB Problem: Normal-weight obesity (NWO) is associated with increased cardiovascular disease (CVD) risk. However, NWO's clinical presentation is often unremarkable based on common risk factors. We examined whether CVD risk factors not routinely measured clinically including postprandial triglycerides, flow-mediated dilation (FMD), and inflammatory cytokines would be abnormal in NWO, consistent with their future risk.Methods: Individuals were recruited into 3 groups (n = 10/ group): controls (Con), NWO, and metabolic syn-drome (MetS). Con was defined as a normal body mass index (BMI), < 25% (M) or < 35% (F) body fat, and < 1 International Diabetes Federation (IDF) criteria. NWO were above this body fat cutoff while maintaining a normal BMI and MetS was defined per the IDF. Participants underwent an abbreviated fat tolerance test (i.e., difference in fasting and 4 h triglycerides following a high-fat meal [9 kcal/kg; 73% fat)] and fasting and postprandial lipid and glucose metrics, as well as FMD were measured. A T cell cytokine bioplex was also per -formed using fasting serum.Results: NWO and MetS had similar body fat% and both were higher than Con (p < 0.0001). Despite having similar fasting triglycerides to Con, NWO had 4-hour triglycerides 66% greater than Con, but 46% lower than MetS (p < 0.01). FMD decreased in all groups after the high-fat meal (p < 0.0001). MetS displayed lower fasting FMD than Con, and NWO was similar to both groups (p < 0.05). No group differences were observed with postprandial FMD and the majority of fasting cytokines assessed. However, MetS exhibited higher fasting TNF-alpha than Con (p < 0.05), and NWO was similar to both groups.Conclusions: Overall, NWO was associated with higher postprandial triglycerides than Con, but displayed little evidence of impaired vascular health or inflammation.
C1 [Keirns, Bryant H.; Hart, Samantha M.; Sciarrillo, Christina M.; Poindexter, Kara L.; Clarke, Stephen L.; Emerson, Sam R.] Oklahoma State Univ, Dept Nutr Sci, Stillwater, OK 74078 USA.
C3 Oklahoma State University System; Oklahoma State University - Stillwater
RP Keirns, BH (corresponding author), Oklahoma State Univ, Dept Nutr Sci, Stillwater, OK 74078 USA.
EM bryant.keirns@okstate.edu
OI , Stephen/0000-0001-8313-9638; Emerson, Sam/0000-0001-7439-0871
CR [Anonymous], IDF CONSENSUS WORDWI
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NR 37
TC 4
Z9 5
U1 0
U2 5
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1871-403X
EI 1878-0318
J9 OBES RES CLIN PRACT
JI Obes. Res. Clin. Pract.
PD SEP-OCT
PY 2022
VL 16
IS 5
BP 386
EP 392
DI 10.1016/j.orcp.2022.08.008
PG 7
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 6R9PR
UT WOS:000892630600001
PM 36127280
DA 2025-06-11
ER

PT J
AU Totaro, M
   Dimarakis, S
   Castellini, C
   D'Andrea, S
   Parisi, A
   D'Amato, F
   Tienforti, D
   Palazzi, S
   Baroni, MG
   Francavilla, S
   Barbonetti, A
AF Totaro, Maria
   Dimarakis, Sotirios
   Castellini, Chiara
   D'Andrea, Settimio
   Parisi, Antonio
   D'Amato, Federica
   Tienforti, Daniele
   Palazzi, Sara
   Baroni, Marco Giorgio
   Francavilla, Sandro
   Barbonetti, Arcangelo
TI Erectile dysfunction in hyperuricemia: A prevalence meta-analysis and
   meta-regression study
SO ANDROLOGY
LA English
DT Review
DE diabetes; gout; impotence; metabolic syndrome; sexual function; uric
   acid
ID SERUM URIC-ACID; MUSCLE-CELL-PROLIFERATION; CORONARY-ARTERY-DISEASE;
   NITRIC-OXIDE PRODUCTION; METABOLIC SYNDROME; ENDOTHELIAL DYSFUNCTION;
   ESSENTIAL-HYPERTENSION; OXIDATIVE STRESS; RISK PREDICTOR; BLOOD-PRESSURE
AB Background Whether and to what extent an association exists between hyperuricemia and erectile dysfunction (ED) has not yet been fully determined. Objective To define pooled prevalence estimates and correlates of erectile dysfunction in men with hyperuricemic disorders. Materials and methods A thorough search of Medline, Scopus, and Cochrane Library databases was performed. Data were combined using random-effects models and the between-study heterogeneity was assessed by Cochrane's Q and I-2 tests. A funnel plot was used to assess publication bias. Results Overall, 8 studies included gave information about 85,406 hyperuricemic men, of whom 5023 complained of erectile dysfunction, resulting in a pooled erectile dysfunction prevalence estimate of 33% (95% Confidence Interval: 13-52%; I-2 = 99.9%). The funnel plot suggested the presence of a publication bias. At the meta-regression analyses, among the available covariates that could affect estimates, only type 2 diabetes mellitus was significantly associated with a higher prevalence of erectile dysfunction (beta = 0.08; 95% Confidence Interval: 0.01, 0.15, p = 0.025). At the sub-group analysis, the pooled erectile dysfunction prevalence decreased to 4% (95% Confidence Interval: 0%-8%) when only the largest studies with the lowest prevalence of type 2 diabetes mellitus were included and increased up to 50% (95% Confidence Interval: 17%-84%) when the analysis was restricted to studies enrolling smaller series with higher prevalence of type 2 diabetes mellitus. Conclusions A not negligible proportion of men with hyperuricemia can complain of erectile dysfunction. While a pathogenetic contribution of circulating uric acid in endothelial dysfunction cannot be ruled out, the evidence of a stronger association between hyperuricemia and erectile dysfunction in type 2 diabetes mellitus points to hyperuricemia as a marker of systemic dysmetabolic disorders adversely affecting erectile function.
C1 [Totaro, Maria; Dimarakis, Sotirios; Castellini, Chiara; D'Andrea, Settimio; Parisi, Antonio; D'Amato, Federica; Tienforti, Daniele; Palazzi, Sara; Francavilla, Sandro; Barbonetti, Arcangelo] Univ Laquila, Dept Life Hlth & Environm Sci, Androl Unit, Ple S Tommasi 1, I-67100 Laquila, Italy.
   [Baroni, Marco Giorgio] Univ Laquila, Dept Life Hlth & Environm Sci, Laquila, Italy.
C3 University of L'Aquila; University of L'Aquila
RP Barbonetti, A (corresponding author), Univ Laquila, Dept Life Hlth & Environm Sci, Androl Unit, Ple S Tommasi 1, I-67100 Laquila, Italy.
EM arcangelo.barbonetti@univaq.it
RI Castellini, Chiara/AHH-0131-2022; Baroni, Marco Giorgio/AIA-6973-2022;
   Tienforti, Daniele/MHR-3628-2025; D'Andrea, Settimio/P-4769-2018
OI Parisi, Antonio/0000-0002-2440-9332; Baroni, Marco
   Giorgio/0000-0002-3224-6078; CASTELLINI, CHIARA/0000-0003-4729-4248;
   Tienforti, Daniele/0000-0002-9359-7955; Totaro,
   Maria/0000-0002-2589-5635
FU Ministero dell'Istruzione, Universita eRicerca (MIUR) [2017XLFJAX]
FX Ministero dell'Istruzione, Universita eRicerca (MIUR);, Grant/Award
   Number: 2017XLFJAX.
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NR 59
TC 20
Z9 22
U1 0
U2 15
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2047-2919
EI 2047-2927
J9 ANDROLOGY-US
JI Andrology
PD JAN
PY 2022
VL 10
IS 1
BP 72
EP 81
DI 10.1111/andr.13088
EA AUG 2021
PG 10
WC Andrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA XW6TV
UT WOS:000685917400001
PM 34347943
OA Bronze
DA 2025-06-11
ER

PT J
AU Kisabay, A
   Sari, US
   Cakiroglu Aldemir, E
   Oktan, B
   Korkmaz, T
   Dinç Horasan, G
   Yilmaz, H
AF Kisabay, Aysin
   Sari, U. Serpil
   Cakiroglu Aldemir, Eda
   Oktan, Bilge
   Korkmaz, Tugba
   Dinc Horasan, Gonul
   Yilmaz, Hikmet
TI Effects of CPAP (Continous Positive Airway Pressure) Treatment on
   Oxidative Stress and Pro-Inflammatory Process
SO JOURNAL OF NEUROLOGICAL SCIENCES-TURKISH
LA English
DT Article
DE Obstructive sleep apnea syndrome; continuous positive airway pressure;
   subclinical; atherosclerosis
ID OBSTRUCTIVE SLEEP-APNEA; C-REACTIVE PROTEIN; CORONARY-ARTERY-DISEASE;
   NITRIC-OXIDE; ENDOTHELIAL FUNCTION; PLASMA HOMOCYSTEINE;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; FIBRINOGEN LEVELS; THERAPY
AB Introduction: Obstructive sleep apnea syndrome (OSAS) is an independent risk factor for development of atherosclerotic processes because it leads to hypertension, impaired glucose metabolism, obesity and metabolic syndrome, cardiac diseases, elevated blood pressure, and increased level of cholesterol, triglycerides, homocysteine, and coagulation.
   Materials and Methods: Our aim was to evaluate presence of subclinical atherosclerosis prior to CPAP treatment in the patients with OSAS without any history of previous diseases and any pathological finding in their investigations. After obtaining approval from the Ethics Board, we planned to compare the results of investigations for risk factors for atherosclerosis (fasting blood glucose [FBG], total cholesterol, Triglycerides, HDL- and LDL-cholesterol, thyroid function test, homocysteine, fibrinogen, high sensitivity C-reactive protein [hsCRP]) before and after CPAP treatment and to examine the effect of CPAP treatment on these parameters between July 2013 and July 2015.
   Findings: Findings obtained before CPAP treatment (homocysteine, hsCRP, HbA1c, subclinical hypothyroidism) suggested subclinical atherosclerosis. In comparative evaluation between the findings before and after CPAP treatment, no statistically significant difference was found in levels of triglycerides, HDL-cholesterol and fT4 (P = 0.346, 0.540, 0.060, respectively) whereas significant differences were found in leukocyte and platelet counts, hemoglobin level, fasting blood glucose, LDL-cholesterol, homocysteine, fibrinogen, fT3, TSH, CRP, and HbA1c (P = 0,003,-0,010,-0,000,-0,001,-0,008-0,004-0,000-0,000-0,0250,000- 0,000-0,000, respectively). Subclinical hypothyroidism was present in 12 (20%) patients before CPAP and in 5 (7%) patients after CPAP treatment.
   Conclusions: Improvement has been seen even in early markers of atherosclerosis with effective CPAP.
C1 [Kisabay, Aysin; Sari, U. Serpil; Cakiroglu Aldemir, Eda; Oktan, Bilge; Korkmaz, Tugba; Yilmaz, Hikmet] Celal Bayar Univ, Norol, Manisa, Turkey.
   [Dinc Horasan, Gonul] Celal Bayar Univ, Halk Sagligi, Manisa, Turkey.
C3 Celal Bayar University; Celal Bayar University
RP Kisabay, A (corresponding author), Celal Bayar Univ, Norol, Manisa, Turkey.
EM aysinkisabay@hotmail.com
RI korkmaz, tugba/AAV-7399-2021
OI Dinc Horasan, Gonul/0000-0001-9999-4102
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NR 68
TC 3
Z9 3
U1 1
U2 5
PU JOURNAL NEUROLOGICAL SCIENCES
PI BORNOVA-IZMIR
PA EGE UNIV HOSP. FAC MED, DEPT NEUROSURGERY, BORNOVA-IZMIR, TR35100,
   TURKEY
SN 1302-1664
J9 J NEUROL SCI-TURK
JI J. Neurol. Sci.-Turk.
PY 2016
VL 33
IS 2
BP 264
EP 277
PG 14
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA EE6TC
UT WOS:000389744400008
DA 2025-06-11
ER

PT J
AU Aroor, A
   McKarns, S
   Nistala, R
   DeMarco, V
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   Whaley-Connell, A
   Sowers, JR
AF Aroor, Annayya
   McKarns, Susan
   Nistala, Ravi
   DeMarco, Vincent
   Gardner, Michael
   Garcia-Touza, Mariana
   Whaley-Connell, Adam
   Sowers, James R.
TI DPP-4 Inhibitors as Therapeutic Modulators of Immune Cell Function and
   Associated Cardiovascular and Renal Insulin Resistance in Obesity and
   Diabetes
SO CARDIORENAL MEDICINE
LA English
DT Article
DE DPP-4; Cardiorenal syndrome; Obesity; Diabetes; Insulin resistance
ID REGULATORY T-CELLS; DIPEPTIDYL PEPTIDASE-4 INHIBITOR; BODY-MASS INDEX;
   METABOLIC SYNDROME; KIDNEY-DISEASE; ANGIOTENSIN-II; ENDOTHELIAL
   FUNCTION; EXCHANGER NHE3; BLOOD-PRESSURE; INFLAMMATION
AB The prevalence of obesity and diabetes continues to rise in the United States and worldwide. These findings parallel the expansion of childhood obesity and diabetes. Obesity is a central component of the cardiorenal metabolic syndrome (CRS) which increases the risk for cardiovascular disease (CVD) and chronic kidney disease (CKD). The hallmark of obesity, CRS, and early type 2 diabetes is insulin resistance, a result of decreased insulin metabolic signaling due, in part, to enhanced serine phosphorylation and/or proteasome-mediated degradation of the insulin receptor substrate. Cardiovascular and renal insulin resistance significantly contributes to endothelial dysfunction, impaired cardiac diastolic and vascular relaxation, glomerular injury, and tubular dysfunction. In this context, multiple factors including oxidative stress, increased inflammation, and inappropriate activation of the renin-angiotensin-aldosterone and the sympathetic nervous system contribute to overweight- and obesity-induced systemic and tissue insulin resistance. One common link between obesity and the development of insulin resistance appears to be a low-grade inflammatory response resulting from dysfunctional innate and adaptive immunity. In this regard, there has been recent work on the role of dipeptidyl peptidase-4 (DPP-4) in modulating innate and adaptive immunity. The direct effects of DPP-4 on immune cells and the indirect effects through GLP-1-dependent and -in-dependent pathways suggest effects of DPP-4 inhibition may have beneficial effects beyond glycemic control in improving CVD and renal outcomes. Accordingly, this review addresses new insights into the role of DPP-4 in immune modulation and the potential beneficial effects of DPP-4 inhibitors in insulin resistance and associated CVD and CKD prevention. Copyright (C) 2013 S. Karger AG, Basel
C1 [Aroor, Annayya; Gardner, Michael; Garcia-Touza, Mariana; Sowers, James R.] Univ Missouri, Sch Med, Dept Internal Med, Div Endocrinol Diabet & Metab, Columbia, MO 65212 USA.
   [Nistala, Ravi; Whaley-Connell, Adam] Univ Missouri, Sch Med, Dept Internal Med, Div Nephrol & Hypertens, Columbia, MO 65212 USA.
   [DeMarco, Vincent; Sowers, James R.] Univ Missouri, Sch Med, Dept Med Pharmacol & Physiol, Columbia, MO 65212 USA.
   [McKarns, Susan] Univ Missouri, Sch Med, Dept Surg, Columbia, MO 65212 USA.
   [McKarns, Susan] Univ Missouri, Sch Med, Dept Mol Microbiol & Immunol, Columbia, MO 65212 USA.
   [Aroor, Annayya; Nistala, Ravi; Whaley-Connell, Adam; Sowers, James R.] Harry S Truman Mem Vet Hosp, Columbia, MO 65201 USA.
C3 University of Missouri System; University of Missouri Columbia;
   University of Missouri System; University of Missouri Columbia;
   University of Missouri System; University of Missouri Columbia;
   University of Missouri System; University of Missouri Columbia;
   University of Missouri System; University of Missouri Columbia; US
   Department of Veterans Affairs; Veterans Health Administration (VHA);
   Harry S. Truman Memorial Veterans' Hospital
RP Aroor, A (corresponding author), Univ Missouri, Diabet Ctr D109, UHC 1 Hosp Dr, Columbia, MO 65212 USA.
EM aroora@health.missouri.edu
OI Whaley-Connell, Adam/0000-0001-8955-5560; DeMarco,
   Vincent/0000-0003-2092-9995
FU NIH [R01 HL73101-01A, R01 HL107910-01]; Veterans Affairs Merit System
   [0018]
FX This research was supported by NIH (R01 HL73101-01A and R01 HL107910-01)
   and the Veterans Affairs Merit System (0018) to J.R.S.
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NR 77
TC 42
Z9 45
U1 0
U2 16
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1664-3828
EI 1664-5502
J9 CARDIORENAL MED
JI CardioRenal Med.
PY 2013
VL 3
IS 1
BP 48
EP 56
DI 10.1159/000348756
PG 9
WC Cardiac & Cardiovascular Systems; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Urology & Nephrology
GA 135ZG
UT WOS:000318328600006
PM 23946724
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Verreth, W
   De Keyzer, D
   Pelat, M
   Verhamme, P
   Ganame, J
   Bielicki, JK
   Mertens, A
   Quarck, R
   Benhabilès, N
   Marguerie, G
   Mackness, B
   Mackness, M
   Ninio, E
   Herregods, MC
   Balligand, JL
   Holvoet, P
AF Verreth, W
   De Keyzer, D
   Pelat, M
   Verhamme, P
   Ganame, J
   Bielicki, JK
   Mertens, A
   Quarck, R
   Benhabilès, N
   Marguerie, G
   Mackness, B
   Mackness, M
   Ninio, E
   Herregods, MC
   Balligand, JL
   Holvoet, P
TI Weight loss-associated induction of peroxisome proliferator-activated
   receptor-α and peroxisome proliferator-activated receptor-γ correlate
   with reduced atherosclerosis and improved cardiovascular function in
   obese insulin-resistant mice
SO CIRCULATION
LA English
DT Article
DE atherosclerosis; circadian rhythm; genes; lipoproteins; obesity
ID LOW-DENSITY-LIPOPROTEIN; BLOOD-PRESSURE VARIABILITY; CIRCULATING
   OXIDIZED LDL; CORONARY-HEART-DISEASE; ADIPOSE-TISSUE; PPAR-GAMMA;
   PLASMA-LIPOPROTEINS; METABOLIC SYNDROME; LIPID-METABOLISM;
   BODY-COMPOSITION
AB Background - Weight loss in obese insulin-resistant but not in insulin-sensitive persons reduces coronary heart disease risk. To what extent changes in gene expression are related to atherosclerosis and cardiovascular function is unknown.
   Methods and Results - We studied the effect of diet restriction - induced weight loss on gene expression in the adipose tissue, the heart, and the aortic arch and on atherosclerosis and cardiovascular function in mice with combined leptin and LDL-receptor deficiency. Obesity, hypertriglyceridemia, and insulin resistance are associated with hypertension, impaired left ventricular function, and accelerated atherosclerosis in those mice. Compared with lean mice, peroxisome proliferator - activated receptors (PPAR)-alpha and PPAR-gamma expression was downregulated in obese double-knockout mice. Diet restriction caused a 45% weight loss, an upregulation of PPAR-alpha and PPAR-gamma, and a change in the expression of genes regulating glucose transport and insulin sensitivity, lipid metabolism, oxidative stress, and inflammation, most of which are under the transcriptional control of these PPARs. Changes in gene expression were associated with increased insulin sensitivity, decreased hypertriglyceridemia, reduced mean 24-hour blood pressure and heart rate, restored circadian variations of blood pressure and heart rate, increased ejection fraction, and reduced atherosclerosis. PPAR-alpha and PPAR-gamma expression was inversely related to plaque volume and to oxidized LDL content in the plaques.
   Conclusions - Induction of PPAR-alpha and PPAR-gamma in adipose tissue, heart, and aortic arch is a key mechanism for reducing atherosclerosis and improving cardiovascular function resulting from weight loss. Improved lipid metabolism and insulin signaling is associated with decreased tissue deposition of oxidized LDL that increases cardiovascular risk in persons with the metabolic syndrome.
C1 Katholieke Univ Leuven, Ctr Expt Surg & Anesthesiol, Cardiovasc Res Unit, B-3000 Louvain, Belgium.
   Katholieke Univ Leuven, Dept Cardiol, B-3000 Louvain, Belgium.
   Catholic Univ Louvain, Dept Med, Unit Pharmacol & Therapeut, B-3000 Louvain, Belgium.
   Univ Calif Berkeley, Lawrence Berkeley Lab, Berkeley, CA 94720 USA.
   Univ Manchester, Manchester Royal Infirm, Dept Med, Manchester M13 9WL, Lancs, England.
   Clinigenet, Nimes, France.
   Univ Paris 06, INSERM, U525, Inst Federatif CMV, Paris, France.
C3 KU Leuven; KU Leuven; Universite Catholique Louvain; United States
   Department of Energy (DOE); Lawrence Berkeley National Laboratory;
   University of California System; University of California Berkeley;
   University of Manchester; Institut National de la Sante et de la
   Recherche Medicale (Inserm); Sorbonne Universite
RP Katholieke Univ Leuven, Ctr Expt Surg & Anesthesiol, Cardiovasc Res Unit, Herestr 49, B-3000 Louvain, Belgium.
EM paul.holvoet@med.kuleuven.ac.be
RI HOLVOET, PAUL/T-8434-2017; Verhamme, Peter/JEF-6302-2023; Balligand,
   Jean-Luc/D-7543-2012; Quarck, Rozenn/J-8067-2018
OI Quarck, Rozenn/0000-0002-8293-6261; Mertens, Ann/0000-0002-1649-4311;
   Verhamme, Peter/0000-0001-8698-2858; BALLIGAND,
   Jean-Luc/0000-0002-0522-4156; Holvoet, Paul/0000-0001-9201-0772
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NR 56
TC 110
Z9 121
U1 0
U2 8
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0009-7322
EI 1524-4539
J9 CIRCULATION
JI Circulation
PD NOV 16
PY 2004
VL 110
IS 20
BP 3259
EP 3269
DI 10.1161/01.CIR.0000147614.85888.7A
PG 11
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 871DQ
UT WOS:000225109900017
PM 15533870
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Arany, I
   Hall, S
   Reed, DK
   Reed, CT
   Dixit, M
AF Arany, Istvan
   Hall, Samuel
   Reed, Dustin K.
   Reed, Caitlyn T.
   Dixit, Mehul
TI Nicotine Enhances High-Fat Diet-Induced Oxidative Stress in the Kidney
SO NICOTINE & TOBACCO RESEARCH
LA English
DT Article
ID CIGARETTE-SMOKING; METABOLIC SYNDROME; UNITED-STATES; BODY-WEIGHT;
   CELL-DEATH; INJURY; EXPOSURE; PROGRESSION; OBESITY; NEPHROPATHY
AB Life expectancy of an obese smoker is 13 years less than a normal weight smoker, which could be linked to the increased renal risk imposed by smoking. Both smoking-through nicotine (NIC)-and obesity-by free fatty acid overload-provoke oxidative stress in the kidney, which ultimately results in development of chronic kidney injury. Their combined renal risk, however, is virtually unknown. We tested the hypothesis that chronic NIC exposure worsens renal oxidative stress in mice on high-fat diet (HFD) by altering the balance between expression of pro-oxidant and antioxidant genes.
   Nine-week-old male C57Bl/6J mice consumed normal diet (ND) or HFD and received either NIC (200 mu g/ml) or vehicle (2% saccharine) in their drinking water. Body weight, plasma clinical parameters, renal lipid deposition, markers of renal oxidative stress and injury, as well as renal expression of the pro-oxidant p66shc and the antioxidant MnSOD were determined after 12 weeks.
   NIC significantly augmented levels of circulating free fatty acid, as well as lipid deposition, oxidative stress and sublethal injury in the kidneys of mice on HFD. In addition, NIC exposure suppressed HFD-mediated induction of MnSOD while increased expression of p66shc in the kidney.
   Tobacco smoking or the increasingly popular E-cigarettes-via NIC exposure-could worsen obesity-associated lipotoxicity in the kidney. Hence, our findings could help to develop strategies that mitigate adverse effects of NIC on the obese kidney.
   Life expectancy of an obese smoker is 13 years less than a normal weight smoker, which could be linked to the increased renal risk imposed by smoking. NIC-the main component of tobacco smoke, E-cigarettes and replacement therapies-links smoking to renal injury via oxidative stress, which could superimpose renal oxidative stress caused by obesity. Our results substantiate this scenario using a mouse model of diet induced obesity and NIC exposure and imply the augmented long-term renal risk in obese smokers. Also, our study may help to develop strategies that mitigate adverse effects of NIC on the obese kidney.
C1 [Arany, Istvan; Hall, Samuel; Reed, Dustin K.; Dixit, Mehul] Univ Mississippi, Div Pediat Nephrol, Dept Pediat, Med Ctr, Res Wing Room R116-B,2500 N State St, Jackson, MS 39216 USA.
   [Reed, Caitlyn T.] Univ Mississippi, Dept Pathol, Med Ctr, Jackson, MS 39216 USA.
C3 University of Mississippi Medical Center; University of Mississippi;
   University of Mississippi; University of Mississippi Medical Center
RP Arany, I (corresponding author), Univ Mississippi, Div Pediat Nephrol, Dept Pediat, Med Ctr, Res Wing Room R116-B,2500 N State St, Jackson, MS 39216 USA.
EM iarany@umc.edu
FU Department of Pediatrics, University of Mississippi Medical Center;
   Bower Foundation
FX This work was supported by a grant from the Department of Pediatrics,
   University of Mississippi Medical Center to MD and the Bower Foundation.
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NR 47
TC 31
Z9 33
U1 0
U2 15
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1462-2203
EI 1469-994X
J9 NICOTINE TOB RES
JI Nicotine Tob. Res.
PD JUL
PY 2016
VL 18
IS 7
BP 1628
EP 1634
DI 10.1093/ntr/ntw029
PG 7
WC Substance Abuse; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Substance Abuse; Public, Environmental & Occupational Health
GA DR3TW
UT WOS:000379826500012
PM 26896163
DA 2025-06-11
ER

PT J
AU Manukhina, EB
   Downey, HF
   Shi, XR
   Mallet, RT
AF Manukhina, Eugenia B.
   Downey, H. Fred
   Shi, Xiangrong
   Mallet, Robert T.
TI Intermittent hypoxia training protects cerebrovascular function in
   Alzheimer's disease
SO EXPERIMENTAL BIOLOGY AND MEDICINE
LA English
DT Article
DE Alzheimer's disease; brain ischemia; cerebral circulation;
   cerebrovascular risk factors; cognitive function; intermittent hypoxia
   training; neurodegeneration; nitric oxide; nitrosative stress; oxidative
   stress; vasoprotection
ID CEREBRAL-BLOOD-FLOW; ENDOTHELIAL NITRIC-OXIDE; VASCULAR RISK-FACTORS;
   SMALL VESSEL DISEASE; OBSTRUCTIVE SLEEP-APNEA; BRAIN OXIDATIVE STRESS;
   HYPOBARIC-HYPOXIA; PHYSICAL-EXERCISE; HIPPOCAMPAL NEUROGENESIS; ABERRANT
   EXPRESSION
AB Alzheimer's disease (AD) is a leading cause of death and disability among older adults. Modifiable vascular risk factors for AD (VRF) include obesity, hypertension, type 2 diabetes mellitus, sleep apnea, and metabolic syndrome. Here, interactions between cerebrovascular function and development of AD are reviewed, as are interventions to improve cerebral blood flow and reduce VRF. Atherosclerosis and small vessel cerebral disease impair metabolic regulation of cerebral blood flow and, along with microvascular rarefaction and altered trans-capillary exchange, create conditions favoring AD development. Although currently there are no definitive therapies for treatment or prevention of AD, reduction of VRFs lowers the risk for cognitive decline. There is increasing evidence that brief repeated exposures to moderate hypoxia, i.e. intermittent hypoxic training (IHT), improve cerebral vascular function and reduce VRFs including systemic hypertension, cardiac arrhythmias, and mental stress. In experimental AD, IHT nearly prevented endothelial dysfunction of both cerebral and extra-cerebral blood vessels, rarefaction of the brain vascular network, and the loss of neurons in the brain cortex. Associated with these vasoprotective effects, IHT improved memory and lessened AD pathology. IHT increases endothelial production of nitric oxide (NO), thereby increasing regional cerebral blood flow and augmenting the vaso- and neuroprotective effects of endothelial NO. On the other hand, in AD excessive production of NO in microglia, astrocytes, and cortical neurons generates neurotoxic peroxynitrite. IHT enhances storage of excessive NO in the form of S-nitrosothiols and dinitrosyl iron complexes. Oxidative stress plays a pivotal role in the pathogenesis of AD, and IHT reduces oxidative stress in a number of experimental pathologies. Beneficial effects of IHT in experimental neuropathologies other than AD, including dyscirculatory encephalopathy, ischemic stroke injury, audiogenic epilepsy, spinal cord injury, and alcohol withdrawal stress have also been reported. Further research on the potential benefits of IHT in AD and other brain pathologies is warranted.
C1 [Manukhina, Eugenia B.; Downey, H. Fred; Shi, Xiangrong; Mallet, Robert T.] Univ N Texas, Hlth Sci Ctr, Ft Worth, TX 76107 USA.
   [Manukhina, Eugenia B.] Inst Gen Pathol & Pathophysiol, Moscow 125315, Russia.
C3 University of North Texas System; University of North Texas Health
   Science Center; Russian Academy of Medical Sciences; Institute of
   General Pathology & Pathophysiology, RAMS
RP Mallet, RT (corresponding author), Univ N Texas, Hlth Sci Ctr, Ft Worth, TX 76107 USA.
EM Robert.Mallet@unthsc.edu
OI Mallet, Robert/0000-0001-7388-9419
FU Texas Alzheimer's Research and Care Consortium; University of North
   Texas Health Science Center's Center for Alzheimer's and
   Neurodegenerative Disease Research
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: Funding
   for this work was provided to XS by an Investigator Grant from the Texas
   Alzheimer's Research and Care Consortium, and a Pilot Trial Award from
   the University of North Texas Health Science Center's Center for
   Alzheimer's and Neurodegenerative Disease Research
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NR 212
TC 64
Z9 71
U1 1
U2 62
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1535-3702
EI 1535-3699
J9 EXP BIOL MED
JI Exp. Biol. Med.
PD JUN
PY 2016
VL 241
IS 12
BP 1351
EP 1363
DI 10.1177/1535370216649060
PG 13
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA DO8TR
UT WOS:000378057200010
PM 27190276
OA Green Published
DA 2025-06-11
ER

PT J
AU Näslindh-Ylispangar, A
   Sihvonen, M
   Sarna, S
   Kekki, P
AF Naslindh-Ylispangar, Anita
   Sihvonen, Marja
   Sarna, Seppo
   Kekki, Pertti
TI Health status, symptoms and health counselling among middle-aged men:
   comparison of men at low and high risk
SO SCANDINAVIAN JOURNAL OF CARING SCIENCES
LA English
DT Article
DE logistic regression analyse; middle-aged men; metabolic syndrome; health
   behaviour; health counselling
ID CARDIOVASCULAR-DISEASE; PHYSICAL-ACTIVITY; BLOOD-PRESSURE; PRIMARY-CARE;
   OBESITY; WAIST
AB Health status, symptoms and health counselling among middle-aged men: comparison of men at low and high risk
   To assess the levels of health indicators, health behaviour and health counselling among men at low and high risk for adverse health outcomes.
   A total of 273 middle-aged men, 145 at low and 128 at high risk for adverse health outcomes, were studied. Two- and three-way tables with chi-squared tests were performed to identify differences between the groups. A step-wise logistic regression model was used to analyse symptoms and complaints associated with the likelihood of perceived health.
   One-half of the low-risk men were overweight, of whom 8% were obese. Forty per cent of the low-risk men smoked cigarettes and one-fifth used alcohol excessively. Headache, chest and back pain, stress, and insomnia occurred frequently (range: 20-38%) and were highly correlated with depression. Joint pain (p = 0.012) in the low-risk men and sciatica (p = 0.047) in the high-risk men were the only statistically significant differences related to normal weight vs. overweight status. There was a greater than sixfold odds of average/poor health among low-risk men who were depressed than in those who were not depressed men. Only a small percentage of the low-risk men had received counselling from professionals for different health issues, including weight control and smoking cessation; the corresponding percentages were somewhat higher when given by family members.
   A real need for better counselling was found among middle-aged men identified with obesity and risky behaviours. Public health nurses and other health workers should be aware of the differences between men at low and high risk. Men had different health experiences and lifestyles in these groups. More research is needed to determine the most efficient counselling strategies among men.
C1 [Naslindh-Ylispangar, Anita; Sihvonen, Marja; Kekki, Pertti] Univ Helsinki, Dept Gen Practice & Primary Hlth Care, Helsinki, Finland.
   [Sarna, Seppo] Univ Helsinki, Dept Publ Hlth, Helsinki, Finland.
C3 University of Helsinki; University of Helsinki
RP Näslindh-Ylispangar, A (corresponding author), Kauriintie 3 G49, Helsinki 00740 74, Finland.
EM anita.ylispangar@kolumbus.fi
OI Naslindh-Ylispangar, Anita/0009-0003-1369-251X; Sarna,
   Seppo/0000-0003-3458-1627
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NR 42
TC 4
Z9 5
U1 0
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0283-9318
EI 1471-6712
J9 SCAND J CARING SCI
JI Scand. J. Caring Sci.
PD DEC
PY 2008
VL 22
IS 4
BP 529
EP 535
DI 10.1111/j.1471-6712.2007.00565.x
PG 7
WC Nursing
WE Social Science Citation Index (SSCI)
SC Nursing
GA 372BH
UT WOS:000260875900005
PM 18823355
DA 2025-06-11
ER

PT J
AU Lu, Y
   Zhang, JY
   Li, HJ
   Li, T
AF Lu, Yu
   Zhang, Jianyu
   Li, Hejun
   Li, Ting
TI Association of non-alcoholic fatty liver disease with self-reported
   osteoarthritis among the US adults
SO ARTHRITIS RESEARCH & THERAPY
LA English
DT Article
DE Osteoarthritis; NAFLD; NHANES; Cross-sectional; United States
ID ENDOPLASMIC-RETICULUM STRESS; METABOLIC SYNDROME; AMERICAN-COLLEGE;
   DIAGNOSIS; HIP; PATHOGENESIS; MANAGEMENT; STEATOSIS; INSULIN; KNEE
AB BackgroundThe association between non-alcoholic fatty liver disease (NAFLD) and osteoarthritis (OA) has not been well elucidated. The aim of the present study was to investigate the association between NAFLD and OA in the US adults.MethodsA cross-sectional study was performed on participants in the 2017-2018 National Health and Nutrition Examination Survey (NHANES) cycle. NAFLD was defined by the vibration-controlled transient elastography. The diagnosis of OA was based on self-reported data. Weighted multiple logistic regression models and stratified analyses were performed to explore the relationship and verify the stability of the conclusions. Sensitivity analysis using multiple imputation for missing data and propensity score matching (PSM) were performed.ResultsIn total, 2622 participants [Male: 1260 (47.8%)] were included in this study with a mean age of 48.1 years old (95% CI, 46.6-49.6 years old), containing 317 (12.8%) OA patients and 1140 NAFLD patients (41.5%). A logistic regression indicated a significant association between NAFLD and OA without adjustment [odds ratio (OR) = 2.05; 95% CI, 1.52-2.78]. The association remained stable after adjustment for covariates (OR = 1.72; 95% CI, 1.26-2.34). Sensitivity analysis of missing data with multiple interpolation and PSM found similar results. A significant and consistent association of NAFLD with OA was still observed in each subgroup stratified by age and metabolic syndrome (MetS). Stratified by sex, obesity, and sensitivity c-reactive protein (hs-CRP) category, a statistically significant association was only shown in females, those without obesity, and those without hyper hs-CRP. The results illustrated that the relationship between NAFLD and OA was stable in all subgroups and had no interaction.ConclusionsNAFLD was positively correlated with OA. Given the current pandemic of NAFLD and OA, clinicians should screen for NAFLD in arthritis patients and intervene early.
C1 [Lu, Yu; Zhang, Jianyu; Li, Hejun; Li, Ting] Guangzhou Med Univ, Guangdong Prov Clin Res Ctr Obstet & Gynecol, Guangdong Prov Key Lab Major Obstet Dis, Affiliated Hosp 3,Dept Rheumatol & Immunol, Guangzhou, Peoples R China.
C3 Guangzhou Medical University
RP Li, T (corresponding author), Guangzhou Med Univ, Guangdong Prov Clin Res Ctr Obstet & Gynecol, Guangdong Prov Key Lab Major Obstet Dis, Affiliated Hosp 3,Dept Rheumatol & Immunol, Guangzhou, Peoples R China.
EM jiazhutao1202@163.com
RI dai, jianping/AAI-7046-2020
FU Science and Technology Projects in Guangzhou
FX The authors thank the staff of the National Health and Nutrition
   Examination in this study for their indispensable contribution.
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NR 44
TC 4
Z9 4
U1 2
U2 15
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1478-6354
EI 1478-6362
J9 ARTHRITIS RES THER
JI Arthritis Res. Ther.
PD JAN 31
PY 2024
VL 26
IS 1
AR 40
DI 10.1186/s13075-024-03272-2
PG 8
WC Rheumatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Rheumatology
GA GV1V6
UT WOS:001155365400003
PM 38297351
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Beydoun, MA
   Canas, JA
   Beydoun, HA
   Chen, XL
   Shroff, MR
   Zonderman, AB
AF Beydoun, May A.
   Canas, J. Atilio
   Beydoun, Hind A.
   Chen, Xiaoli
   Shroff, Monal R.
   Zonderman, Alan B.
TI Serum Antioxidant Concentrations and Metabolic Syndrome Are Associated
   among U.S. Adolescents in Recent National Surveys
SO JOURNAL OF NUTRITION
LA English
DT Article
ID RETINOL-BINDING-PROTEIN; C-REACTIVE PROTEIN; BETA-CAROTENE
   SUPPLEMENTATION; NUTRITION EXAMINATION SURVEY; TYPE-2 DIABETES-MELLITUS;
   ARTERY RISK DEVELOPMENT; BODY-MASS INDEX; INSULIN-RESISTANCE;
   ALPHA-TOCOPHEROL; VITAMIN-A
AB Specific micronutrients, including retinol, retinyl esters, carotenoids beta-carotene, delta-carotene (cis+trans), p-cryptoxanthin, lutein+zeaxanthin, and total lycopene], vitamin E, and vitamin C have antiinflammatory and antioxidant effects, properties shown to reduce oxidative stress, a process that accompanies the pathogenesis of many chronic diseases. It is still largely unknown whether they are associated with the occurrence of metabolic syndrome (MetS) in the adolescent U.S. population. MetS was defined by the International Diabetes Federation (IDF) criteria. Other non-MetS outcomes relying on blood measurements were elevated HOMA-IR, C-reactive protein (CRP), and hyperuricemia. We tested associations between serum antioxidants and MetS outcomes among adolescents aged 12-19 gamma using cross-sectional data from NHANES 2001-2006 (n = 782-4285). IDF MetS prevalence was estimated at 7% among boys and 3% among girls. In adjusted models, adolescents with MetS had consistently lower carotenoid concentrations compared with their counterparts without MetS. Total carotenoids were also inversely related to HOMA-IR and CRP. Vitamin C was inversely related to uric acid level and MetS binary outcome, Retinol+retinyl esters exhibited an inverse relationship with CRP and a positive relationship with uric acid and HOMA-IR as well as MetS binary outcome. Vitamin E had no association with MetS, particularly after controlling for serum cholesterol and TG. In conclusion, among U.S. adolescents, serum carotenoid concentrations were inversely associated with MetS status, HOMA-IR, and CRP, whereas serum vitamin C was inversely related to MetS status and serum uric acid. Vitamin E had no consistent association with MetS, whereas retinol+retinyl esters had a positive relationship with HOMA-IR, uric acid, and MetS, while being inversely related to CRP. These associations need further study. J. Nutr. 142: 1693-1704,2012.
C1 [Beydoun, May A.; Zonderman, Alan B.] NIA, NIH, Baltimore, MD 21224 USA.
   [Beydoun, May A.; Zonderman, Alan B.] Intramural Res Program, Baltimore, MD USA.
   [Canas, J. Atilio] Pediat Endocrinol Diabet & Metab Nemours Children, Jacksonville, FL USA.
   [Beydoun, Hind A.] Eastern Virginia Med Sch, Grad Program Publ Hlth, Norfolk, VA 23501 USA.
   [Chen, Xiaoli] Johns Hopkins Univ, Dept Int Hlth, Bloomberg Sch Publ Hlth, Ctr Human Nutr, Baltimore, MD USA.
   [Shroff, Monal R.] Michigan Publ Hlth Inst, Okemos, MI USA.
C3 National Institutes of Health (NIH) - USA; NIH National Institute on
   Aging (NIA); Eastern Virginia Medical School; Johns Hopkins University;
   Johns Hopkins Bloomberg School of Public Health
RP Beydoun, MA (corresponding author), NIA, NIH, Baltimore, MD 21224 USA.
EM baydounm@mail.nih.gov
RI Zonderman, Alan/A-5807-2013; Canas, Jose/Y-8500-2019; Canas,
   Jose/F-3193-2017
OI Zonderman, Alan B/0000-0002-6523-4778; Canas, Jose/0000-0003-4788-8820
FU National Institute on Aging, Intramural Research
FX Supported by the National Institute on Aging, Intramural Research.
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NR 107
TC 71
Z9 75
U1 0
U2 19
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0022-3166
EI 1541-6100
J9 J NUTR
JI J. Nutr.
PD SEP
PY 2012
VL 142
IS 9
BP 1693
EP 1704
DI 10.3945/jn.112.160416
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 994CF
UT WOS:000307907800012
PM 22810988
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Bruno, RM
   Penno, G
   Daniele, G
   Pucci, L
   Lucchesi, D
   Stea, F
   Landini, L
   Cartoni, G
   Taddei, S
   Ghiadoni, L
   Del Prato, S
AF Bruno, R. M.
   Penno, G.
   Daniele, G.
   Pucci, L.
   Lucchesi, D.
   Stea, F.
   Landini, L.
   Cartoni, G.
   Taddei, S.
   Ghiadoni, L.
   Del Prato, S.
TI Type 2 diabetes mellitus worsens arterial stiffness in hypertensive
   patients through endothelial dysfunction
SO DIABETOLOGIA
LA English
DT Article
DE Arterial stiffness; Endothelial function; Hypertension; Type 2 diabetes
   mellitus; Vascular endothelium
ID FLOW-MEDIATED DILATION; PULSE-WAVE VELOCITY; METABOLIC SYNDROME;
   BRACHIAL-ARTERY; AORTIC STIFFNESS; ANTIHYPERTENSIVE DRUGS;
   METHODOLOGICAL ISSUES; BLOOD-PRESSURE; SHEAR-STRESS; DILATATION
AB Endothelium-derived factors are thought to be physiological modulators of large artery stiffness. The aim of the study was to investigate whether endothelial function could be a determinant of arterial stiffness in essential hypertensive patients, in relation with the concomitant presence of type 2 diabetes mellitus.
   The study included 341 participants (84 hypertensive patients with and 175 without type 2 diabetes mellitus, 82 matched controls). Brachial artery endothelium-dependent flow-mediated dilation (FMD) was determined by high-resolution ultrasound and computerised edge detection system. Applanation tonometry was used to measure carotid-femoral pulse wave velocity (PWV).
   Hypertensive patients with diabetes had higher PWV (10.1 +/- 2.3 m/s vs 8.6 +/- 1.4 m/s, < 0.001) and lower FMD (3.51 +/- 2.07 vs 5.16 +/- 2.96%, < 0.001) than non-diabetic hypertensive patients, who showed impaired vascular function when compared with healthy participants (7.9 +/- 1.6 m/s and 6.68 +/- 3.67%). FMD was significantly and negatively correlated to PWV only in hypertensive diabetic patients ( = -0.456, < 0.001), but not in hypertensive normoglycaemic patients ( = -0.088, = 0.248) or in healthy participants ( = 0.008, = 0.946). Multivariate analysis demonstrated that, in the diabetic group, FMD remained an independent predictor of PWV after adjustment for confounders ( (2) = 0.083, = 0.003). Subgroup analysis performed in non-diabetic hypertensive patients revealed that neither obesity nor the metabolic syndrome affected the relationship between FMD and PWV.
   Endothelial dysfunction is a determinant of aortic stiffness in hypertensive diabetic patients but not in hypertensive patients without diabetes. These results suggest that type 2 diabetes mellitus on top of hypertension might worsen arterial compliance by endothelium-related mechanisms.
C1 [Bruno, R. M.; Stea, F.; Landini, L.; Cartoni, G.; Taddei, S.; Ghiadoni, L.] Univ Pisa, Dept Internal Med, I-56126 Pisa, Italy.
   [Penno, G.; Daniele, G.; Pucci, L.; Lucchesi, D.; Del Prato, S.] Univ Pisa, Dept Endocrinol & Metab, I-56126 Pisa, Italy.
C3 University of Pisa; University of Pisa
RP Ghiadoni, L (corresponding author), Univ Pisa, Dept Internal Med, Via Roma 67, I-56126 Pisa, Italy.
EM l.ghiadoni@med.unipi.it
RI Ghiadoni, Lorenzo/AAC-5176-2022; Landini, Luigi/AAL-7083-2020; Pucci,
   Laura/AAU-4653-2020; Taddei, Stefano/AAB-2828-2019; Bruno, Rosa
   Maria/C-3594-2015; Daniele, Giuseppe/K-9650-2016; Del Prato,
   Stefano/K-3405-2016
OI Pucci, Laura/0000-0001-7063-6192; Ghiadoni, Lorenzo/0000-0002-7399-2720;
   PUCCI, LAURA/0000-0002-8162-4039; Bruno, Rosa Maria/0000-0002-6107-3356;
   landini, luigi/0000-0002-2534-2651; Daniele,
   Giuseppe/0000-0001-6301-9161; Del Prato, Stefano/0000-0002-5388-0270
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   Virdis A, 2008, CURR PHARM DESIGN, V14, P1761, DOI 10.2174/138161208784746707
   Wallace SML, 2007, HYPERTENSION, V50, P228, DOI 10.1161/HYPERTENSIONAHA.107.089391
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NR 41
TC 89
Z9 94
U1 0
U2 10
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0012-186X
EI 1432-0428
J9 DIABETOLOGIA
JI Diabetologia
PD JUN
PY 2012
VL 55
IS 6
BP 1847
EP 1855
DI 10.1007/s00125-012-2517-1
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 939KK
UT WOS:000303808900031
PM 22411135
DA 2025-06-11
ER

PT J
AU Weigensberg, MJ
   Toledo-Corral, CM
   Goran, MI
AF Weigensberg, Marc J.
   Toledo-Corral, Claudia M.
   Goran, Michael I.
TI Association between the metabolic syndrome and serum cortisol in
   overweight Latino youth
SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Article
ID PITUITARY-ADRENAL AXIS; 3RD NATIONAL-HEALTH; BETA-CELL FUNCTION;
   INSULIN-RESISTANCE; ADIPOSE-TISSUE; FAMILY-HISTORY; YOUNG-ADULTS;
   IN-VITRO; CHILDREN; OBESITY
AB Objective: The purpose of this report is to investigate the associations between metabolic syndrome (MS) and levels of morning serum cortisol in a cohort of overweight Latino youth.
   Design: Subjects were 205 overweight, Latino youth (age 8-13 yr, body mass index percentile >85, family history positive for type 2 diabetes). Measures included body composition by dual-energy x-ray absorptiometry, intraabdominal adipose tissue (IAAT) by magnetic resonance imaging, insulin sensitivity by frequently sampled iv glucose tolerance test/minimal model, fasting lipids, and serum cortisol.
   Results: Children with MS had higher body mass index percentile, total body fat mass, and IAAT and lower insulin sensitivity than those without MS. Children with MS had higher morning serum cortisol levels, whether unadjusted (10.1 +/- 3.7 vs. 9.0 +/- 2.8 mu g/dl, P < 0.05) or after adjusting for age, gender, total body fat and lean tissue mass, and insulin sensitivity (10.4 +/- 0.4 vs. 8.9 +/- 0.3 mu g/dl, P < 0.01). Increasing number of features of MS was associated with higher cortisol levels, after adjusting for covariates (P = 0.001). Among individual features of MS, systolic blood pressure had the strongest relationship with adjusted cortisol level (r = 0.34; P < 0.001), followed by diastolic blood pressure and fasting plasma glucose (both r = 0.23; P < 0.01). IAAT was associated with cortisol (r = 0.16; P < 0.05), whereas high-density lipoprotein, triglycerides, and waist circumference were not.
   Conclusions: In overweight, Latino youth, MS is associated with higher morning serum cortisol levels, independent of body fat and insulin sensitivity. More studies are needed to investigate the role of relative hypercortisolism and chronic stress in obesity-related metabolic disorders in children.
C1 Univ So Calif, Dept Pediat, Los Angeles, CA 90089 USA.
   Univ So Calif, Dept Prevent Med, Los Angeles, CA 90089 USA.
   Univ So Calif, Dept Physiol & Biophys, Los Angeles, CA 90089 USA.
C3 University of Southern California; University of Southern California;
   University of Southern California
RP Weigensberg, MJ (corresponding author), Univ So Calif, Dept Pediat, 2250 Alcazar St,CSC 200, Los Angeles, CA 90089 USA.
EM weigensb@usc.edu
RI Toledo-Corral, Claudia/J-5299-2019
OI Toledo-Corral, Claudia/0000-0002-1228-9070
FU NCRR NIH HHS [M01 RR 00043, M01 RR000043] Funding Source: Medline; NIDDK
   NIH HHS [R01-DK-59211, F31 DK081276, R01 DK059211] Funding Source:
   Medline
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NR 41
TC 103
Z9 120
U1 0
U2 13
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0021-972X
EI 1945-7197
J9 J CLIN ENDOCR METAB
JI J. Clin. Endocrinol. Metab.
PD APR
PY 2008
VL 93
IS 4
BP 1372
EP 1378
DI 10.1210/jc.2007-2309
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 284AI
UT WOS:000254677200044
PM 18252788
OA Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Kuchay, MS
   Choudhary, NS
   Mishra, SK
AF Kuchay, Mohammad Shafi
   Choudhary, Narendra Singh
   Mishra, Sunil Kumar
TI Pathophysiological mechanisms underlying MAFLD
SO DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS
LA English
DT Article
DE Metabolic associated fatty liver disease; Metabolic associated
   steatohepatitis; TAZ/IHH pathway; Notch pathway; Extracellular vesicles;
   Fibroblast growth factor 19; Bone morphogenetic protein 8B;
   Non-alcoholic fatty liver disease; NASH
ID FATTY LIVER-DISEASE; HEPATIC STELLATE CELLS; INFLAMMATORY EXTRACELLULAR
   VESICLES; ENDOPLASMIC-RETICULUM STRESS; APOLIPOPROTEIN-B GENE;
   NECROSIS-FACTOR-ALPHA; FARNESOID-X-RECEPTOR; NONALCOHOLIC
   STEATOHEPATITIS; METABOLIC SYNDROME; INSULIN-RESISTANCE
AB Background and aims: The pathophysiology underlying metabolic associated fatty liver disease (MAFLD) involves a multitude of interlinked processes, including insulin resistance (IR) underlying the metabolic syndrome, lipotoxicity attributable to the accumulation of toxic lipid species, infiltration of proinflammatory cells causing hepatic injury and ultimately leading to hepatic stellate cell (HSC) activation and fibrogenesis. The proximal processes, such as IR, lipid overload and lipotoxicity are relatively well established, but the downstream molecular mechanisms, such as inflammatory processes, hepatocyte lipoapoptosis, and fibrogenesis are incompletely understood.
   Methods: A literature search was performed with Medline (PubMed), Scopus and Google Scholar electronic databases till June 2020, using relevant keywords (nonalcoholic fatty liver disease; metabolic associated fatty liver disease; nonalcoholic steatohepatitis; NASH pathogenesis) to extract relevant studies describing pathogenesis of MAFLD/MASH.
   Results: Several studies have reported new concepts underlying pathophysiology of MAFLD. Activation of HSCs is the common final pathway for diverse signals from damaged hepatocytes and proinflammatory cells. Activated HSCs then secrete excess extracellular matrix (ECM) which accumulates and impairs structure and function of the liver. TAZ (a transcriptional regulator), hedgehog (HH) ligands, transforming growth factor-beta (TGF-beta), bone morphogenetic protein 8B (BMP8B) and osteopontin play important roles in activating these HSCs. Dysfunctional gut microbiome, dysregulated bile acid metabolism, endogenous alcohol production, and intestinal fructose handling, modify individual susceptibility to MASH.
   Conclusions: Newer concepts of pathophysiology underlying MASH, such as TAZ/Ihh pathway, extracellular vesicles, microRNA, dysfunctional gut microbiome and intestinal fructose handling present promising targets for the development of therapeutic agents. (C) 2020 Diabetes India. Published by Elsevier Ltd. All rights reserved.
C1 [Kuchay, Mohammad Shafi; Mishra, Sunil Kumar] Medanta Medicity Hosp, Div Endocrinol & Metab, Gurugram 122001, Haryana, India.
   [Choudhary, Narendra Singh] Medanta Medicity Hosp, Inst Digest & Hepatobiliary Sci, Gurugram 122001, Haryana, India.
RP Kuchay, MS (corresponding author), Medanta Medicity Hosp, Div Endocrinol & Metab, Gurugram 122001, Haryana, India.
EM drshafikuchay@gmail.com
RI Kuchay, M/IZQ-0398-2023; Kuchay, Mohammad Shafi/L-6152-2017
OI Kuchay, Mohammad Shafi/0000-0003-3933-6137; Choudhary,
   Narendra/0000-0002-4387-0036
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NR 168
TC 101
Z9 105
U1 2
U2 30
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1871-4021
EI 1878-0334
J9 DIABETES METAB SYND
JI Diabetes Metab. Syndr.-Clin. Res. Rev.
PD NOV-DEC
PY 2020
VL 14
IS 6
BP 1875
EP 1887
DI 10.1016/j.dsx.2020.09.026
PG 13
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA PO7TE
UT WOS:000605370300058
PM 32998095
DA 2025-06-11
ER

PT J
AU McPherson, NO
   Lanel, M
AF McPherson, Nicole O.
   Lanel, Michelle
TI Metformin treatment of high-fat diet-fed obese male mice restores sperm
   function and fetal growth, without requiring weight loss
SO ASIAN JOURNAL OF ANDROLOGY
LA English
DT Article
DE fertility; glucose; metabolic syndrome; overweight; subfertility
ID INDUCED PATERNAL OBESITY; BODY-MASS INDEX; METABOLIC SYNDROME;
   GLUCOSE-TRANSPORT; TESTICULAR TISSUE; PARENTAL OBESITY; OXIDATIVE
   STRESS; MOUSE; EXERCISE; RISK
AB Male obesity is associated with subfertility and increased disease risk of offspring. It is unknown if effects can be reversed through pharmacological interventions. Five- to 6-week-old C57BL6 male mice were fed control diet (n = 10, CD) or high-fat diet (n = 20, HFD) for 16 weeks. Animals fed with a HFD were then allocated to continuation of HFD (n = 8) or HFD with metformin 28 mg kg(-1) day(-1) (n = 8) for 6 weeks. Animals fed with CD continued on a CD (n = 9). Males were mated with fertile C57BL6 females for the assessment of pregnancy and fetal growth. Sperm motility, spermatozoa and testicular morphology, sperm-zona pellucida binding, sperm reactive oxygen species (ROS) (intracellular [DCFDA], superoxide [MSR], and oxidative DNA lesions [80HdG]), and mitochondrial membrane potential (JC1) were assessed. Metformin treatment of HFD males improved glucose tolerance (+12%, P < 0.05) and reduced Homeostatic Model Assessment of Insulin Resistance (HOMA-IR; -36%, P < 0.05). This occurred in the absence of a change in bodyweight or adiposity. Metformin treatment of HFD-fed males restored testicular morphology (+33%, P < 0.05), sperm motility (+66%, P < 0.05), sperm-zona pellucida binding (+25%, P < 0.05), sperm intracellular ROS concentrations (-32%, P < 0.05), and oxidative DNA lesions (-45%, P < 0.05) to the levels of the CD males. Metformin treatment of HFD fathers increased fetal weights and lengths compared with those born to HFD fathers (+8%, P < 0.05), with fetal lengths restored to those of fetuses of CD males. Short-term metformin treatment in men who are obese could be a potential intervention for the treatment of subfertility, without the need for a reduction in body weight/adiposity.
C1 [McPherson, Nicole O.; Lanel, Michelle] Univ Adelaide, Robinson Res Inst, Sch Med, Adelaide, SA 5005, Australia.
   [McPherson, Nicole O.; Lanel, Michelle] Univ Adelaide, Freemasons Fdn Ctr Mens Hlth, Adelaide, SA 5005, Australia.
   [McPherson, Nicole O.] Repromed, Dulwich 5065, Australia.
   [Lanel, Michelle] Monash IVF Grp, Melbourne, Vic 3000, Australia.
C3 Robinson Research Institute; University of Adelaide; University of
   Adelaide
RP McPherson, NO (corresponding author), Univ Adelaide, Robinson Res Inst, Sch Med, Adelaide, SA 5005, Australia.; McPherson, NO (corresponding author), Univ Adelaide, Freemasons Fdn Ctr Mens Hlth, Adelaide, SA 5005, Australia.; McPherson, NO (corresponding author), Repromed, Dulwich 5065, Australia.
EM nicole.mcpherson@adelaide.edu.au
OI McPherson, Nicole/0000-0002-3492-9403
FU NHMRC Early Career Fellowship
FX ML and NOM are paid employees of the Monash IVF group. NOM is the
   recipient of an NHMRC Early Career Fellowship.
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NR 63
TC 16
Z9 17
U1 2
U2 7
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, Maharashtra, INDIA
SN 1008-682X
EI 1745-7262
J9 ASIAN J ANDROL
JI Asian J. Androl.
PD NOV-DEC
PY 2020
VL 22
IS 6
BP 560
EP +
DI 10.4103/aja.aja_141_19
PG 10
WC Andrology; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Urology & Nephrology
GA OP9WB
UT WOS:000588442200004
PM 32098932
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Jain, S
   Puri, N
   Rana, A
   Sirianni, N
   Mopidevi, B
   Kumar, A
AF Jain, Sudhir
   Puri, Nitin
   Rana, Anita
   Sirianni, Natalie
   Mopidevi, Brahmaraju
   Kumar, Ashok
TI Metabolic Syndrome Induces Over Expression of the Human AT1R: A
   Haplotype-Dependent Effect With Implications on Cardio-Renal Function
SO AMERICAN JOURNAL OF HYPERTENSION
LA English
DT Article
DE angiotensin receptor type I; blood pressure; high fat diet;
   hypertension; single nucleotide polymorphism; transgenic
ID HUMAN ANGIOTENSINOGEN GENE; INCREASES BLOOD-PRESSURE; TRANSCRIPTION
   FACTOR USF; DIET-INDUCED OBESITY; TRANSGENIC MICE;
   GLUCOCORTICOID-RECEPTOR; INSULIN-RESISTANCE; HEART-FAILURE; SYSTEM;
   OVEREXPRESSION
AB BACKGROUND
   The transcriptional regulation of the human angiotensin receptor subtype 1 (AT1R) gene in pathophysiologies, like the metabolic syndrome, is poorly understood. The human AT1R gene has polymorphisms in its promoter that can be arranged in 2 haplotypes. Variants -810T, -713T, -214A, and -153A always occur together (Hap-I) and variants -810A, -713G, -214C, and -153G form Hap-II. We have hypothesized that high fat diet will alter cellular transcriptional milieu and increase hAT1R gene expression in a haplotype-dependent manner. This will set up an AT1R-mediated feed-forward loop promoting inflammation, oxidative stress, and hypertension in Hap-I mice.
   METHOD
   Since Hap-I of the human AT1R gene is associated with hypertension in Caucasians, we generated transgenic (TG) mice with Hap-I and Hap-II and studied the physiological significance of high fat diet (HFD) on haplotype specific gene expression. Animals were fed with HFD for 20 weeks followed by blood pressure (BP) analysis and collection of their tissues for molecular and biochemical studies.
   RESULTS
   After HFD treatment, as compared to Hap-II, TG mice with Hap-I show increased expression of hAT1R gene and higher BP; suppression of antioxidant defenses (HO1, SOD1) and increased expression of IL-6, TNF alpha, IL-1 beta, NOX1. In vivo ChIP assay has shown that transcription factors CEBP beta, STAT3, and USF bind more strongly to the chromatin obtained from Hap-I TG mice.
   CONCLUSIONS
   Taken together, our results suggest, that after HFD treatment, as compared to Hap-II, the TG mice with Hap-I overexpress the AT1R gene due to the stronger transcriptional activity, thus resulting in an increase in their BP.
C1 [Jain, Sudhir; Mopidevi, Brahmaraju; Kumar, Ashok] New York Med Coll, Dept Pathol Basic Sci Bldg, New York, NY 10029 USA.
   [Puri, Nitin; Rana, Anita; Sirianni, Natalie] Univ Toledo, Coll Med, Dept Physiol & Pharmacol, Toledo, OH 43606 USA.
C3 New York Medical College; University System of Ohio; University of
   Toledo
RP Jain, S (corresponding author), New York Med Coll, Dept Pathol Basic Sci Bldg, New York, NY 10029 USA.
EM sjain5@nymc.edu
RI Mopidevi, Brahmaraju/D-6003-2015
OI Mopidevi, Brahmaraju/0000-0003-1231-7796
FU NIH [HL81752, HL105113, HL092558]
FX This work was supported, in whole or in part, by NIH grants HL81752,
   HL105113, and HL092558 (to A.K.). S.J., N.P., and A.K designed the
   research. S.J., A.R., M.K., and N.S., B.M. performed the experiments.
   S.J., N.P., M.K., and A.K. analyzed the data. S.J. and N.P wrote the
   manuscript.
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PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0895-7061
EI 1941-7225
J9 AM J HYPERTENS
JI Am. J. Hypertens.
PD APR
PY 2018
VL 31
IS 4
BP 495
EP 503
DI 10.1093/ajh/hpx176
PG 9
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA FY9GH
UT WOS:000427173200019
PM 29036458
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Briançon-Marjollet, A
   Weiszenstein, M
   Henri, M
   Thomas, A
   Godin-Ribuot, D
   Polak, J
AF Briancon-Marjollet, Anne
   Weiszenstein, Martin
   Henri, Marion
   Thomas, Amandine
   Godin-Ribuot, Diane
   Polak, Jan
TI The impact of sleep disorders on glucose metabolism: endocrine and
   molecular mechanisms
SO DIABETOLOGY & METABOLIC SYNDROME
LA English
DT Article
DE Sleep; Obstructive sleep apnea; Shift working; Intermittent hypoxia;
   Metabolic syndrome; Diabetes; Obesity; Insulin resistance
ID CHRONIC INTERMITTENT HYPOXIA; C-REACTIVE PROTEIN; EYE-MOVEMENT SLEEP;
   IMPROVES INSULIN SENSITIVITY; BODY DENERVATION PREVENTS; BLOOD-PRESSURE
   ELEVATION; POSITIVE AIRWAY PRESSURE; ISCHEMIC-HEART-DISEASE; WHITE
   ADIPOSE-TISSUE; ALL-CAUSE MORTALITY
AB Modern lifestyle has profoundly modified human sleep habits. Sleep duration has shortened over recent decades from 8 to 6.5 hours resulting in chronic sleep deprivation. Additionally, irregular sleep, shift work and travelling across time zones lead to disruption of circadian rhythms and asynchrony between the master hypothalamic clock and pacemakers in peripheral tissues. Furthermore, obstructive sleep apnea syndrome (OSA), which affects 4 - 15% of the population, is not only characterized by impaired sleep architecture but also by repetitive hemoglobin desaturations during sleep. Epidemiological studies have identified impaired sleep as an independent risk factor for all cause of-, as well as for cardiovascular, mortality/morbidity. More recently, sleep abnormalities were causally linked to impairments in glucose homeostasis, metabolic syndrome and Type 2 Diabetes Mellitus (T2DM). This review summarized current knowledge on the metabolic alterations associated with the most prevalent sleep disturbances, i.e. short sleep duration, shift work and OSA. We have focused on various endocrine and molecular mechanisms underlying the associations between inadequate sleep quality, quantity and timing with impaired glucose tolerance, insulin resistance and pancreatic beta-cell dysfunction. Of these mechanisms, the role of the hypothalamic-pituitary-adrenal axis, circadian pacemakers in peripheral tissues, adipose tissue metabolism, sympathetic nervous system activation, oxidative stress and whole-body inflammation are discussed. Additionally, the impact of intermittent hypoxia and sleep fragmentation (key components of OSA) on intracellular signaling and metabolism in muscle, liver, fat and pancreas are also examined. In summary, this review provides endocrine and molecular explanations for the associations between common sleep disturbances and the pathogenesis of T2DM.
C1 [Briancon-Marjollet, Anne; Henri, Marion; Thomas, Amandine; Godin-Ribuot, Diane] Univ Grenoble Alpes, HP2, F-38041 Grenoble, France.
   [Briancon-Marjollet, Anne; Henri, Marion; Thomas, Amandine; Godin-Ribuot, Diane] INSERM, U1042, F-38041 Grenoble, France.
   [Weiszenstein, Martin; Polak, Jan] Charles Univ Prague, Fac Med 3, Ctr Res Diabet Metab & Nutr, Prague, Czech Republic.
   [Polak, Jan] Univ Hosp Kralovske Vinohrady, Dept Internal Med 2, Prague, Czech Republic.
   [Polak, Jan] Charles Univ Prague, Fac Med 3, Sports Med Dept, Prague 10000 10, Czech Republic.
   Charles Univ Prague, Fac Med 3, Sports Med Dept, Prague 10000 10, Czech Republic.
C3 Communaute Universite Grenoble Alpes; Universite Grenoble Alpes (UGA);
   Institut National de la Sante et de la Recherche Medicale (Inserm);
   Charles University Prague; University Hospital Vinohrady; Charles
   University Prague; Charles University Prague
RP Polak, J (corresponding author), Charles Univ Prague, Fac Med 3, Ctr Res Diabet Metab & Nutr, Prague, Czech Republic.
EM jan.polak@lf3.cuni.cz
RI Briançon-Marjollet, Anne/AFM-6918-2022; Briancon-Marjollet,
   Anne/M-7298-2014; Polak, Jan/J-3404-2014; Godin-Ribuot,
   Diane/B-6945-2014
OI Briancon-Marjollet, Anne/0000-0002-3341-300X; Polak,
   Jan/0000-0001-9964-652X; Godin-Ribuot, Diane/0000-0001-7589-932X
FU Grant Agency of Czech Republic [GACR P304/13-27735S]; Agir@Dom funding
   (Grenoble, France)
FX The work has been supported by the Grant Agency of Czech Republic, GACR
   P304/13-27735S and from Agir@Dom funding (Grenoble, France).
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NR 322
TC 169
Z9 193
U1 2
U2 85
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1758-5996
J9 DIABETOL METAB SYNDR
JI Diabetol. Metab. Syndr.
PD MAR 24
PY 2015
VL 7
AR 25
DI 10.1186/s13098-015-0018-3
PG 16
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA CE8CL
UT WOS:000352068600001
PM 25834642
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Norazman, CW
   Sopian, MM
   Lee, LK
AF Norazman, Camilla Wahida
   Sopian, Mastura Mohd
   Lee, Lai Kuan
TI Effects of tocotrienol-enriched oat supplementation on metabolic
   profile, nutritional status and health-related quality of life among
   patients with metabolic syndrome
SO FOOD & FUNCTION
LA English
DT Article
ID NONALCOHOLIC FATTY LIVER; BETA-GLUCAN; VITAMIN-E; INSULIN SENSITIVITY;
   BLOOD CHOLESTEROL; OXIDATIVE STRESS; GLYCEMIC CONTROL; WHOLE-GRAIN;
   WEIGHT-LOSS; ADULTS
AB Background: Tocotrienol has garnered significant attention due to its potent antioxidant and anti-inflammatory effects in ameliorating cardiovascular-related comorbidities. The present study aimed to elucidate the effects of tocotrienol-enriched oat supplementation on individuals with metabolic syndrome (MetS). Method: This was a randomized, double-blind, placebo-controlled human clinical trial. Patients with MetS were randomized to the tocotrienol-enriched oat (TO), oat (O) or control (C) groups. Both TO and O groups were supplemented twice daily for 12 weeks, while group C did not receive any intervention. Changes in the metabolic profile of individuals were considered as the primary endpoint. The secondary endpoints included the morphological assessment of nutritional and anthropometric parameters and health-related quality of life. Other measurements included compliance and tolerability to the study regime. Results: The rate of MetS remission in the TO and O groups was approximately twice than that in the control group (37.0% vs. 18.5%). After 12 weeks, the TO group showed significant improvements in the fasting blood glucose (-4.5%), blood pressure (systolic: -4.2%; diastolic: -5.3%), high density lipoprotein-cholesterol (HDL-C) (+34.1%), and triglyceride (-7.1%) (p < 0.05) levels. Group TO demonstrated an increase in muscle mass (+0.301 kg, p < 0.05) and reduced body fat (-0.775%, p < 0.05). Both the TO and O groups showed improvements in the overall HR-QoL, and the visual analogue scale (VAS) score. Conclusion: Twelve weeks of tocotrienol-enriched oat supplementation improved surrogate endpoints associated with MetS. This complementary dietary management approach may be more effective at alleviating MetS symptoms than the pharmacological approach alone and could be a safe dietary strategy for secondary prevention.
C1 [Norazman, Camilla Wahida; Lee, Lai Kuan] Univ Sains Malaysia, Sch Ind Technol, Food Technol Program, Gelugor 11800, Pulau Pinang, Malaysia.
   [Sopian, Mastura Mohd] Univ Sains Malaysia, Clin Med Dept, Bertam Med Ctr, Kepala Batas 13200, Pulau Pinang, Malaysia.
C3 Universiti Sains Malaysia; Universiti Sains Malaysia
RP Lee, LK (corresponding author), Univ Sains Malaysia, Sch Ind Technol, Food Technol Program, Gelugor 11800, Pulau Pinang, Malaysia.
EM l.k.lee@usm.my
RI Lee, Lai/B-3930-2018
FU Gold Choice Food Industries Sdn. Bhd. [R247]
FX The authors acknowledge the financial support provided by the Gold
   Choice Food Industries Sdn. Bhd. [project code: R247].
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NR 93
TC 0
Z9 0
U1 3
U2 3
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PD MAR 3
PY 2025
VL 16
IS 5
BP 1847
EP 1863
DI 10.1039/d4fo03307h
EA FEB 2025
PG 17
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA Z1V8S
UT WOS:001417976100001
PM 39930892
OA hybrid
DA 2025-06-11
ER

PT J
AU Laurent, S
   Boutouyrie, P
AF Laurent, Stephane
   Boutouyrie, Pierre
CA Vasc Mechanism Collaboration
TI Dose-Dependent Arterial Destiffening and Inward Remodeling After
   Olmesartan in Hypertensives With Metabolic Syndrome
SO HYPERTENSION
LA English
DT Article
DE antihypertensive agents; aorta; arteries; blood pressure; compliance;
   hypertension; randomized controlled trial
ID CONVERTING ENZYME-INHIBITION; EXPERT CONSENSUS DOCUMENT; AORTIC
   STIFFNESS; BLOOD-PRESSURE; TERM; TELMISARTAN; CANDESARTAN; PREVENTION;
   VALSARTAN; EVENTS
AB Whether angiotensin receptor blockers can dose-dependently remodel the arterial wall during long-term treatment has been largely debated. In this phase III, multicenter, randomized, double-blind, parallel-group study, 133 subjects with hypertension and metabolic syndrome were assigned to olmesartan, either 20 mg (n=44), 40 mg (n=42), or 80 mg (n=47) once a day, according to a force titration design during a 1-year period. Office blood pressure, 24-hour blood pressure, aortic stiffness (carotid-femoral pulse wave velocity), and carotid parameters were measured at baseline, 24 weeks, and 52 weeks. Pulse wave velocity significantly decreased (P<0.001) with time in each group, with no significant time-dose interaction, despite a tendency (P=0.0685) for a smaller effect of 20 mg, compared with 40 and 80 mg at week 52. When the 40 and 80 mg doses were combined (40/80 mg versus 20 mg), a significant blood pressure-independent reduction in pulse wave velocity (-0.61 m/s) was observed at week 52 (P=0.0066), whereas the nonadjusted reduction was -1.31 m/s (P<0.0001). By contrast, after 20 mg, the blood pressure-independent reduction in pulse wave velocity was not significant. Patients receiving the highest dose of olmesartan (40 and 80 mg) had an inward carotid remodeling and were shifted toward a lower elastic modulus at a given circumferential wall stress, indicating an improvement in the intrinsic elastic properties of the carotid artery wall material. These data suggest that 40 and 80 mg olmesartan were able to significantly remodel and destiffen the arterial wall material during long-term treatment, partly independently of blood pressure, compared with 20 mg.
C1 [Laurent, Stephane; Boutouyrie, Pierre] Univ Paris 05, F-75015 Paris, France.
   [Laurent, Stephane; Boutouyrie, Pierre] INSERM, U970, Paris, France.
   [Laurent, Stephane; Boutouyrie, Pierre] Hop Europeen Georges Pompidou, AP HP, Paris, France.
C3 Universite Paris Cite; Institut National de la Sante et de la Recherche
   Medicale (Inserm); Universite Paris Cite; Assistance Publique Hopitaux
   Paris (APHP); Universite Paris Cite; Hopital Universitaire Europeen
   Georges-Pompidou - APHP
RP Laurent, S (corresponding author), Univ Paris 05, Hop Europeen Georges Pompidou, Dept Pharmacol, 20 Rue Leblanc, F-75015 Paris, France.
EM stephane.laurent@egp.aphp.fr
RI Laurent, Stephane/J-8624-2015; Boutouyrie, Pierre/J-8592-2015
OI Stehouwer, Coen/0000-0001-8752-3223; wilkinson, ian/0000-0001-6598-9399;
   Boutouyrie, Pierre/0000-0002-4375-3569
FU Daiichi Sankyo Europe; (CRO; SGS Life Science)
FX This study was supported by Daiichi Sankyo Europe. The sponsor
   participated in discussions regarding the design and conduct of the
   study and provided logistical support during the trial. Monitoring of
   the study and maintenance of the trial was performed by a contract
   research organization (CRO; SGS Life Science) under contract with the
   sponsor. Collection management and analysis of the data were performed
   by the sponsor and the CRO under contract with the sponsor. The article
   was prepared by the authors. The sponsor was permitted to review the
   article and suggest changes, but the final approval of content was
   exclusively retained by the authors.
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NR 32
TC 78
Z9 79
U1 0
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0194-911X
EI 1524-4563
J9 HYPERTENSION
JI Hypertension
PD OCT
PY 2014
VL 64
IS 4
BP 709
EP +
DI 10.1161/HYPERTENSIONAHA.114.03282
PG 13
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA AP3PB
UT WOS:000341988000007
PM 25001274
DA 2025-06-11
ER

PT J
AU Bhuvaneswar, CG
   Baldessarini, RJ
   Harsh, VL
   Alpert, JE
AF Bhuvaneswar, Chaya G.
   Baldessarini, Ross J.
   Harsh, Veronica L.
   Alpert, Jonathan E.
TI Adverse Endocrine and Metabolic Effects of Psychotropic Drugs Selective
   Clinical Review
SO CNS DRUGS
LA English
DT Review
ID PLACEBO-CONTROLLED TRIAL; INDUCED WEIGHT-GAIN; ANTIPSYCHOTIC-INDUCED
   HYPERPROLACTINEMIA; NEPHROGENIC DIABETES-INSIPIDUS; POLYCYSTIC OVARIAN
   SYNDROME; INDUCED SEXUAL DYSFUNCTION; BONE-MINERAL DENSITY;
   DOUBLE-BLIND; ATYPICAL ANTIPSYCHOTICS; SCHIZOPHRENIC-PATIENTS
AB The article critically reviews selected, clinically significant, adverse endocrine and metabolic effects associated with psychotropic drug treatments, including hyperprolactinaemia, hyponatraemia, diabetes insipidus, hypothyroidism, hyperparathyroidism, sexual dysfunction and virilization, weight loss, weight gain and metabolic syndrome (type 2 diabetes mellitus, dyslipidaemia and hypertension). Such effects are prevalent and complex, but can be managed clinically when recognized. They encourage continued critical assessment of benefits versus risks of psychotropic drugs and underscore the importance of close coordination of psychiatric and general medical care to improve long-term health of psychiatric patients. Options for management of hyperprolactinaemia include lowering doses, switching to agents such as aripiprazole, clozapine or quetiapine, managing associated osteoporosis, carefully considering the use of dopamine receptor agonists; and ruling out stress, oral contraceptive use and hypothyroidism as contributing factors. Disorders of water homeostasis may include syndrome of inappropriate antidiuretic hormone (SIADH), managed by water restriction or slow replacement by hypertonic saline along with drug discontinuation. Safe management of diabetes insipidus, commonly associated with lithium, involves switching mood stabilizer and consideration of potassium-sparing diuretics. Clinical hypothyroidism may be a more useful marker than absolute cut-offs of hormone values, and may be associated with quetiapine, antidepressant and lithium use, and managed by thyroxine replacement. Hyper-parathyroidism requires comprehensive medical evaluation for occult tumours. Hypocalcaemia, along with multiple other psychiatric and medical causes, may result in decreased bone density and require evaluation and management. Strategies for reducing sexual dysfunction with psychotropics remain largely unsatisfactory. Finally, management strategies for obesity and metabolic syndrome are reviewed in light of the recent expert guidelines, including risk assessment and treatments, such as monoamine transport inhibitors, anticonvulsants; and cannabinoid receptor antagonists, as well as lifestyle changes.
C1 [Bhuvaneswar, Chaya G.] Univ Penn, Dept Psychiat, Philadelphia, PA 19104 USA.
   [Baldessarini, Ross J.; Alpert, Jonathan E.] Harvard Univ, Sch Med, Dept Psychiat, Boston, MA 02115 USA.
   [Baldessarini, Ross J.; Alpert, Jonathan E.] Massachusetts Gen Hosp, Boston, MA 02114 USA.
   [Baldessarini, Ross J.] McLean Hosp, Belmont, MA 02178 USA.
   [Harsh, Veronica L.] NIMH, Behav Endocrinol Branch, Bethesda, MD 20892 USA.
C3 University of Pennsylvania; Harvard University; Harvard Medical School;
   Harvard University; Harvard University Medical Affiliates; Massachusetts
   General Hospital; Harvard University; Harvard University Medical
   Affiliates; McLean Hospital; National Institutes of Health (NIH) - USA;
   NIH National Institute of Mental Health (NIMH)
RP Bhuvaneswar, CG (corresponding author), Univ Penn, Hosp Univ Penn, Outpatient Clin, Dept Psychiat, 3535 Market St,2nd Floor, Philadelphia, PA 19104 USA.
EM cbhospitalpsychiatry@live.com
RI Baldessarini, Ross/ADO-8296-2022; Alpert, Jonathan/HPG-6395-2023
OI Alpert, Jonathan/0000-0002-4332-908X
FU American Psychiatric Institute for Research and Education (APIRE); NIMH
   Diversity Supplement; Bruce J. Anderson Foundation; McLean Private
   Donors Fund
FX Supported, in part, by an American Psychiatric Institute for Research
   and Education (APIRE)-Janssen Research Scholarship and NIMH Diversity
   Supplement grant (to CGB) and by a grant from the Bruce J. Anderson
   Foundation and McLean Private Donors Fund for Psychopharmacology
   Research (to RJB). Drs John D. Matthews, Theodore A. Stern and Muhamet
   Yildiz, PhD provided helpful advice.Dr Bhuvaneswar has received training
   awards from: Merck, Janssen, Johnson and Johnson, Novartis, Sepracor,
   Cypress Bio and Infiniti Pharmaceuticals. Dr Baldessarini has recently
   been a consultant or investigator-initiated research collaborator with:
   Auritec, Biotrofix, IFA SpA, Janssen, JDS, Lilly, NeuroHealing,
   Novartis, Solvay and SK-BioPharmaceuticals Corporations. Dr Harsh has no
   relevant disclosures. Dr Alpert is a consultant or has received research
   support from: Aspect Medical Systems, Lilly, Forest, Organon, Pamlab,
   Pfizer and Pharmavite, and honoraria from Organon and Janssen
   Corportions. No author is a member of pharmaceutical speakers' bureaus
   nor do they or family members hold equity positions in biomedical or
   pharmaceutical corporations.
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NR 248
TC 63
Z9 71
U1 0
U2 32
PU ADIS INT LTD
PI NORTHCOTE
PA 5 THE WAREHOUSE WAY, NORTHCOTE 0627, AUCKLAND, NEW ZEALAND
SN 1172-7047
EI 1179-1934
J9 CNS DRUGS
JI CNS Drugs
PY 2009
VL 23
IS 12
BP 1003
EP 1021
DI 10.2165/11530020-000000000-00000
PG 19
WC Clinical Neurology; Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA 538EV
UT WOS:000273168000002
PM 19958039
DA 2025-06-11
ER

PT J
AU Wojcik-Grzybek, D
   Hubalewska-Mazgaj, M
   Surmiak, M
   Sliwowski, Z
   Dobrut, A
   Mlodzinska, A
   Wojcik, A
   Kwiecien, S
   Magierowski, M
   Mazur-Bialy, A
   Bilski, J
   Brzozowski, T
AF Wojcik-Grzybek, Dagmara
   Hubalewska-Mazgaj, Magdalena
   Surmiak, Marcin
   Sliwowski, Zbigniew
   Dobrut, Anna
   Mlodzinska, Agata
   Wojcik, Adrianna
   Kwiecien, Slawomir
   Magierowski, Marcin
   Mazur-Bialy, Agnieszka
   Bilski, Jan
   Brzozowski, Tomasz
TI The Combination of Intestinal Alkaline Phosphatase Treatment with
   Moderate Physical Activity Alleviates the Severity of Experimental
   Colitis in Obese Mice via Modulation of Gut Microbiota, Attenuation of
   Proinflammatory Cytokines, Oxidative Stress Biomarkers and DNA Oxidative
   Damage in Colonic Mucosa
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE intestinal alkaline phosphatase; voluntary exercise; experimental
   colitis; diet-induced obesity; inflammation; oxidative stress
ID INFLAMMATORY-BOWEL-DISEASE; METABOLIC SYNDROME; HETEROGENEITY;
   MECHANISMS; THERAPIES; EXERCISE; MODELS; IMPACT
AB Inflammatory bowel diseases (IBD) are commonly considered as Crohn's disease and ulcerative colitis, but the possibility that the alterations in gut microbiota and oxidative stress may affect the course of experimental colitis in obese physically exercising mice treated with the intestinal alkaline phosphatase (IAP) has been little elucidated. Mice fed a high-fat-diet (HFD) or normal diet (ND) for 14 weeks were randomly assigned to exercise on spinning wheels (SW) for 7 weeks and treated with IAP followed by intrarectal administration of TNBS. The disease activity index (DAI), grip muscle strength test, oxidative stress biomarkers (MDA, SOD, GSH), DNA damage (8-OHdG), the plasma levels of cytokines IL-2, IL-6, IL-10, IL-12p70, IL-17a, TNF-alpha, MCP-1 and leptin were assessed, and the stool composition of the intestinal microbiota was determined by next generation sequencing (NGS). The TNBS-induced colitis was worsened in obese sedentary mice as manifested by severe colonic damage, an increase in DAI, oxidative stress biomarkers, DNA damage and decreased muscle strength. The longer running distance and weight loss was observed in mice given IAP or subjected to IAP + SW compared to sedentary ones. Less heterogeneous microbial composition was noticed in sedentary obese colitis mice and this effect disappeared in IAP + SW mice. Absence of Alistipes, lower proportion of Turicibacter, Proteobacteria and Faecalibacterium, an increase in Firmicutes and Clostridium, a decrease in oxidative stress biomarkers, 8-OHdG content and proinflammatory cytokines were observed in IAP + SW mice. IAP supplementation in combination with moderate physical activity attenuates the severity of murine colitis complicated by obesity through a mechanism involving the downregulation of the intestinal cytokine/chemokine network and oxidative stress, the modulation of the gut microbiota and an improvement of muscle strength.
C1 [Wojcik-Grzybek, Dagmara; Hubalewska-Mazgaj, Magdalena; Surmiak, Marcin; Sliwowski, Zbigniew; Wojcik, Adrianna; Kwiecien, Slawomir; Magierowski, Marcin; Brzozowski, Tomasz] Jagiellonian Univ Med Coll, Fac Med, Dept Physiol, PL-31531 Krakow, Poland.
   [Dobrut, Anna] Jagiellonian Univ Med Coll, Fac Med, Dept Microbiol, PL-31531 Krakow, Poland.
   [Mlodzinska, Agata] Bioidea Co, PL-02991 Warsaw, Poland.
   [Mazur-Bialy, Agnieszka; Bilski, Jan] Jagiellonian Univ Med Coll, Fac Hlth Sci, Dept Biomech & Kinesiol, Chair Biomed Sci, PL-31008 Krakow, Poland.
C3 Jagiellonian University; Collegium Medicum Jagiellonian University;
   Jagiellonian University; Collegium Medicum Jagiellonian University;
   Jagiellonian University; Collegium Medicum Jagiellonian University
RP Wojcik-Grzybek, D; Brzozowski, T (corresponding author), Jagiellonian Univ Med Coll, Fac Med, Dept Physiol, PL-31531 Krakow, Poland.
EM dagmara1.wojcik@uj.edu.pl; magdalena.hubalewska@uj.edu.pl;
   marcin.surmiak@uj.edu.pl; zbigniew.sliwowski@uj.edu.pl;
   anna.dobrut@uj.edu.pl; agata.mlodzinska@bioidea.com.pl;
   adrianna.wojcik@uj.edu.pl; slawomir.kwiecien@uj.edu.pl;
   m.magierowski@uj.edu.pl; agnieszka.mazur@uj.edu.pl;
   jan.bilski@uj.edu.pl; mpbrzozo@cyf-kr.edu.pl
RI Surmiak, Marcin/GYU-3390-2022; Bilski, Jan/B-3412-2010; Mazur-Bialy,
   Agnieszka/I-4882-2012; Magierowski, Marcin/AFO-9432-2022
OI Wojcik, Adrianna/0000-0002-7187-2151; Magierowski,
   Marcin/0000-0003-0175-5600; Kwiecien, Slawomir/0000-0002-4806-8042;
   Surmiak, Marcin/0000-0001-8396-1488; Mazur-Bialy,
   Agnieszka/0000-0003-1056-8276; Dobrut, Anna/0000-0001-9937-5301;
   Wojcik-Grzybek, Dagmara/0000-0003-3098-9617
FU National Centre of Science in Poland [UMO-2015/19/B/NZ4/03130]
FX This work was funded by research grant no. UMO-2015/19/B/NZ4/03130 from
   the National Centre of Science in Poland (to Tomasz Brzozowski).
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NR 92
TC 11
Z9 13
U1 6
U2 29
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD MAR
PY 2022
VL 23
IS 6
AR 2964
DI 10.3390/ijms23062964
PG 29
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 0C9MQ
UT WOS:000775629500001
PM 35328382
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Gerber, M
   Endes, K
   Brand, S
   Herrmann, C
   Colledge, F
   Donath, L
   Faude, O
   Pühse, U
   Hanssen, H
   Zahner, L
AF Gerber, Markus
   Endes, Katharina
   Brand, Serge
   Herrmann, Christian
   Colledge, Flora
   Donath, Lars
   Faude, Oliver
   Puhse, Uwe
   Hanssen, Henner
   Zahner, Lukas
TI In 6-to 8-year-old children, hair cortisol is associated with body mass
   index and somatic complaints, but not with stress, health-related
   quality of life, blood pressure, retinal vessel diameters, and
   cardiorespiratory fitness
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE Body composition; Cardiorespiratory fitness; Hair cortisol; Quality of
   life; Retinal vessel diameters; Stress
ID LONG-TERM CORTISOL; PITUITARY-ADRENAL ACTIVITY; SCALP HAIR; METABOLIC
   SYNDROME; PHYSICAL-ACTIVITY; PERCEIVED STRESS; SCHOOL; BIOMARKER;
   ADOLESCENCE; CHILDHOOD
AB Objectives: Hair cortisol measurement has become an increasingly accepted approach in endocrinology and biopsychology. However, while in adult research hair cortisol has been proposed as a relevant biomarker for chronic stress (and its adverse consequences), studies with children are scarce. Therefore, the goal of the present exploratory study was, to examine the associations between hair cortisol concentrations (HCCs), stress, and a series of health-related outcomes in a sample of Swiss first grade schoolchildren.
   Methods: The sample consisted of 318 children (53% girls, M-age = 7.26, SD = 0.35). Hair strands were taken near the scalp from a posterior vertex position, and HCCs were tested for the first 3-cm hair segment. Parents provided information about their children's age, gender, parental education, children's stress (recent critical life events, daily hassles), health-related quality of life, and psychosomatic complaints. Body composition, blood pressure, retinal vessel diameters, and cardiorespiratory fitness were measured with established methods.
   Results: In multiple regression analyses, higher HCCs were weakly associated with increased BMI in girls (beta = 0.22, p < 0.001), whereas higher HCCs were associated with increased somatic complaints in boys (beta = 0.20, p < 0.05). No significant relationships were found between HCCs and parental reports of stress, health-related quality of life, blood pressure, retinal vessel diameters, and cardiorespiratory fitness.
   Conclusions: Although small significant relationships were found between HCCs, BMI and somatic complaints, the findings of this exploratory study challenge the view that HCCs can be used as a reliable biomarker of recent critical life events, daily hassles, health-related quality of life, and cardiovascular health indicators in non-clinical young children. (C) 2016 Elsevier Ltd. All rights reserved.
C1 [Gerber, Markus; Endes, Katharina; Brand, Serge; Herrmann, Christian; Colledge, Flora; Donath, Lars; Faude, Oliver; Puhse, Uwe; Hanssen, Henner; Zahner, Lukas] Univ Basel, Dept Sport Exercise & Hlth, Basel, Switzerland.
   [Brand, Serge] Univ Basel, Psychiat Clin, Ctr Affect Stress & Sleep Disorders, Basel, Switzerland.
C3 University of Basel; Swiss School of Public Health (SSPH+); University
   of Basel
RP Gerber, M (corresponding author), Univ Basel, Div Sport & Psychosocial Hlth, Dept Sport Exercise & Hlth, Birsstr 320B, CH-4052 Basel, Switzerland.
EM markus.gerber@unibas.ch
RI Brand, Serge/H-7159-2019; Endes, Katharina/V-4877-2017; Gerber,
   Markus/H-8654-2014; Hanssen, Henner/AEU-2514-2022
OI Faude, Oliver/0000-0002-2832-7780; Donath, Lars/0000-0001-6039-0141;
   Brand, Serge/0000-0003-2175-2765; Herrmann,
   Christian/0000-0003-4190-2361; Hanssen, Henner/0000-0001-5501-4205;
   Gerber, Markus/0000-0001-6140-8948
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NR 67
TC 43
Z9 43
U1 2
U2 34
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
EI 1873-3360
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD FEB
PY 2017
VL 76
BP 1
EP 10
DI 10.1016/j.psyneuen.2016.11.008
PG 10
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA EK1YL
UT WOS:000393723600002
PM 27865992
DA 2025-06-11
ER

PT J
AU Komers, R
   Xu, B
   Fu, Y
   McClelland, A
   Kantharidis, P
   Mittal, A
   Cohen, HT
   Cohen, DM
AF Komers, Radko
   Xu, Bei
   Fu, Yi
   McClelland, Aaron
   Kantharidis, Phillip
   Mittal, Amit
   Cohen, Herbert T.
   Cohen, David M.
TI Transcriptome-Based Analysis of Kidney Gene Expression Changes
   Associated with Diabetes in OVE26 Mice, in the Presence and Absence of
   Losartan Treatment
SO PLOS ONE
LA English
DT Article
ID ENDOPLASMIC-RETICULUM-STRESS; THIOREDOXIN-INTERACTING PROTEIN; TISSUE
   GROWTH-FACTOR; ANGIOTENSIN-RECEPTOR BLOCKADE; LOW-DENSITY-LIPOPROTEIN;
   HIPPEL-LINDAU-DISEASE; ER STRESS; ENDOTHELIAL DYSFUNCTION; METABOLIC
   SYNDROME; OXIDATIVE-STRESS
AB Diabetes is among the most common causes of end-stage renal disease, although its pathophysiology is incompletely understood. We performed next-generation sequencing-based transcriptome analysis of renal gene expression changes in the OVE26 murine model of diabetes (age 15 weeks), relative to non-diabetic control, in the presence and absence of short-term (seven-day) treatment with the angiotensin receptor blocker, losartan (n = 3-6 biological replicates per condition). We detected 1438 statistically significant changes in gene expression across conditions. Of the 638 genes dysregulated in diabetes relative to the non-diabetic state, >70% were down-regulation events. Unbiased functional annotation of genes up-and down-regulated by diabetes strongly associated (p<1x10(-8)) with terms for oxidative stress and for endoplasmic reticulum stress/protein folding. Most of the individual gene products up-or down-regulated with diabetes were unaffected by losartan treatment; however, of the gene products dysregulated in diabetes and influenced by losartan treatment, the vast majority of changes were in the direction of amelioration rather than exacerbation of the diabetic dysregulation. This group of losartan-protected genes associated strongly with annotation terms for endoplasmic reticulum stress, heat shock proteins, and chaperone function, but not oxidative stress; therefore, the losartan-unaffected genes suggest avenues for additional therapeutic opportunity in diabetes. Interestingly, the gene product most highly upregulated by diabetes (>52-fold), encoded by the cationic amino acid transporter Slc7a12, and the gene product most highly downregulated by diabetes (>99%) - encoded by the "pseudogene" Gm6300 - are adjacent in the murine genome, are members of the SLC7 gene family, and are likely paralogous. Therefore, diabetes activates a near-total genetic switch between these two paralogs. Other individual-level changes in gene expression are potentially relevant to diabetic pathophysiology, and novel pathways are suggested. Genes unaffected by diabetes alone but exhibiting increased renal expression with losartan produced a signature consistent with malignant potential.
C1 [Komers, Radko; Xu, Bei; Fu, Yi; Cohen, David M.] Oregon Hlth & Sci Univ, Dept Med, Div Nephrol & Hypertens, Portland, OR 97201 USA.
   [Komers, Radko; Xu, Bei; Fu, Yi; Cohen, David M.] Portland VA Med Ctr, Portland, OR USA.
   [Mittal, Amit; Cohen, Herbert T.] Boston Univ, Sch Med, Nephrol Sect, Boston, MA 02118 USA.
   [McClelland, Aaron; Kantharidis, Phillip] Baker IDI Heart & Diabet Inst, Diabet Div, JDRF Danielle Alberti Mem Ctr Diabet Complicat, Melbourne, Vic, Australia.
C3 Oregon Health & Science University; US Department of Veterans Affairs;
   Veterans Health Administration (VHA); Portland VA Medical Center; Boston
   University; Baker Heart and Diabetes Institute
RP Cohen, DM (corresponding author), Oregon Hlth & Sci Univ, Dept Med, Div Nephrol & Hypertens, Portland, OR 97201 USA.
EM cohend@ohsu.edu
RI Mittal, Amit/K-4766-2017
FU National Institutes of Health; Department of Veterans Affairs; American
   Diabetes Association
FX This work was supported by grants from the National Institutes of
   Health, the Department of Veterans Affairs, and the American Diabetes
   Association (to DMC). The funders had no role in study design, data
   collection and analysis, decision to publish, or preparation of the
   manuscript.
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NR 99
TC 10
Z9 12
U1 0
U2 5
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAY 14
PY 2014
VL 9
IS 5
AR e96987
DI 10.1371/journal.pone.0096987
PG 21
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA AI4TJ
UT WOS:000336857400050
PM 24827579
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Eberle, C
   Fasig, T
   Brüseke, F
   Stichling, S
AF Eberle, Claudia
   Fasig, Teresa
   Brueseke, Franziska
   Stichling, Stefanie
TI Impact of maternal prenatal stress by glucocorticoids on metabolic and
   cardiovascular outcomes in their offspring: A systematic scoping review
SO PLOS ONE
LA English
DT Review
ID PSYCHOSOCIAL STRESS; BLOOD-PRESSURE; EXPOSURE; MECHANISMS; CORTISOL;
   OBESITY; CHILD; ASSOCIATIONS; WEIGHT; MODEL
AB Background
   "Stress" is an emerging problem in our society, health care system as well as patient care, worldwide. Especially by focusing on pre-gestational, gestational but also lactation phases "stress" is to be considered as an own trans-generational risk factor which is associated with adverse metabolic as well cardiovascular outcomes in mothers and their children. Hence, the maternal hypothalamic-pituitary-adrenotrophic (HPA) axis may be stimulated by various "stress" mechanisms as well as risk factors leading to an adverse in utero environment, e.g. by excess exposure of glucocorticoids, contributing to cardio-metabolic disorders in mothers and their offspring.
   Objective
   To review the evidence of in utero programming by focusing on the impact of maternal "stress", on adverse cardio-metabolic outcomes on their offspring later in life, by identifying underlying (patho-) physiological mechanisms (1) as well as adverse short and long-term cardio-metabolic outcomes (2).
   Methods
   We conducted a systematic scoping review to identify publications systematically including reviews, interventional, observational, experimental studies as well as human and animal model studies. MEDLINE (PubMed) and EMBASE databases and reference lists were searched. Peer-reviewed articles from January 2000 until August 2020 were included.
   Results
   Overall, n = 2.634 citations were identified, n = 45 eligible studies were included and synthesized according to their key findings. In brief, maternal hypothalamic-pituitary-adrenotrophic (HPA) axis might play a key role modifying in utero milieu leading to cardio-metabolic diseases in the offspring later in life. However, maternal to adverse cardio-metabolic offspring outcomes, postnatally, such as obesity, hyperglycemia, insulin resistance, diabetes mellitus (DM), Metabolic Syndrome (MetS), cardiovascular disease (CD), hypertension, restricted fetal growth as well as reduced birth, adrenal, and pancreas weights.
   Conclusions
   Women who experienced "stress" as risk factor, as well as their offspring, clearly have a higher risk of adverse short- as well as long-term cardio-metabolic outcomes. Future research work is needed to understand complex transgenerational mechanisms.
C1 [Eberle, Claudia; Fasig, Teresa; Brueseke, Franziska; Stichling, Stefanie] Hsch Fulda Univ Appl Sci, Med Specializat Internal Med & Gen Med, Fulda, Germany.
RP Eberle, C (corresponding author), Hsch Fulda Univ Appl Sci, Med Specializat Internal Med & Gen Med, Fulda, Germany.
EM claudia.eberle@hs-fulda.de
RI Eberle, Claudia/J-8855-2017
OI Eberle, Claudia/0000-0001-7878-2020
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NR 56
TC 47
Z9 50
U1 0
U2 9
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JAN 22
PY 2021
VL 16
IS 1
AR e0245386
DI 10.1371/journal.pone.0245386
PG 14
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Science & Technology - Other Topics
GA PZ7OB
UT WOS:000612929300035
PM 33481865
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Choudhury, S
   Ghosh, S
   Gupta, P
   Mukherjee, S
   Chattopadhyay, S
AF Choudhury, S.
   Ghosh, S.
   Gupta, P.
   Mukherjee, S.
   Chattopadhyay, S.
TI Inflammation-induced ROS generation causes pancreatic cell death through
   modulation of Nrf2/NF-κB and SAPK/JNK pathway
SO FREE RADICAL RESEARCH
LA English
DT Article
DE chronic low-grade inflammation; reactive oxygen species; pancreatic
   dysfunction; LPS/TLR-4/ROS/NF-kappa B pathway
ID NF-KAPPA-B; INDUCED OXIDATIVE STRESS; INSULIN-RESISTANCE;
   GENE-EXPRESSION; C-JUN; APOPTOSIS; ACTIVATION; CANCER; INVOLVEMENT;
   INDUCTION
AB Chronic pancreatitis is characterized by progressive loss of exocrine and endocrine functions of the pancreas and is considered to be the single most important cause for development of pancreatic cancer. Recent evidence suggests that inflammation and oxidative stress play pivotal roles in the development of clinical conditions like pancreatitis, type 2 diabetes mellitus, and metabolic syndrome. Nonetheless, molecular signaling pathways linking inflammation, oxidative stress, and pancreatic cell death are not yet well defined. In this study, bacterial lipopolysaccharide (LPS) was used (injected twice a week for three weeks) to emulate a chronic systemic inflammatory state in experimental Swiss albino mice. Using this model, we traced the genesis of inflammation-induced pancreatic dysfunction and mapped the signaling events which contribute to the induction of this state. Histopathological studies revealed the appearance of cell injuries and increased collagen content in LPS-exposed group, indicative of fibrosis. Assays for intraperitoneal glucose tolerance, insulin levels, and insulin receptor mRNA expression signified inflammation-induced insulin insensitivity. For the first time we present evidence that cellular inflammation and subsequent oxidative stress modulate the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappa B)/NF-E2-related factor 2 or Nuclear factor (erythroid-derived 2)-like 2 pathway and initiates pancreatic cell death by activation of stress-responsive Rho/stress-activated protein kinase or SAPK/Jun-N-terminal kinase (JNK) pathway. Scavenging of intracellular reactive oxygen species (ROS) by a standard antioxidant N-acetyl cysteine led to pancreatic cell survival. The data obtained strongly indicates that the LPS/toll-like receptor-4 or TLR-4/ROS/NF-kappa B pathway is critically involved in the initiation of inflammation, oxidative stress, and pancreatic cell death and might prove to be an excellent choice as a target for novel therapeutic strategies in the management of metabolic disorders.
C1 [Choudhury, S.; Ghosh, S.; Gupta, P.; Mukherjee, S.; Chattopadhyay, S.] Univ Calcutta, Dept Physiol, Kolkata, India.
   [Chattopadhyay, S.] Univ Calcutta, Ctr Res Nanosci & Nanotechnol, Kolkata, India.
C3 University of Calcutta; University of Calcutta
RP Chattopadhyay, S (corresponding author), Univ Coll Sci & Technol, Dept Physiol, 92 Acharya Prafulla Chandra Rd, Kolkata 700009, India.
EM sreyachatterjee@yahoo.com
RI MUKHERJEE, SUDESHNA/ABB-9194-2021; Ghosh, Sayan/ABB-8587-2021
OI mukherjee, sudeshna/0000-0001-5349-4882
FU Department of Biotechnology, Govt. of West Bengal; DST-PURSE;
   DST-INSPIRE; Centre for Research in Nanoscience and Nanotechnology,
   University of Calcutta
FX The authors acknowledge the Department of Biotechnology, Govt. of West
   Bengal; DST-PURSE; DST-INSPIRE and Centre for Research in Nanoscience
   and Nanotechnology, University of Calcutta, for fellowship and grant
   support. The authors would like to acknowledge the central instrument
   facility of CRNN, CU.
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NR 59
TC 79
Z9 91
U1 0
U2 22
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1071-5762
EI 1029-2470
J9 FREE RADICAL RES
JI Free Radic. Res.
PY 2015
VL 49
IS 11
BP 1371
EP 1383
DI 10.3109/10715762.2015.1075016
PG 13
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA DD4KU
UT WOS:000369892600008
PM 26189548
DA 2025-06-11
ER

PT J
AU Iwasa, T
   Matsuzaki, T
   Kinouchi, R
   Fujisawa, S
   Murakami, M
   Kiyokawa, M
   Kuwahara, A
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   Irahara, M
AF Iwasa, Takeshi
   Matsuzaki, Toshiya
   Kinouchi, Riyo
   Fujisawa, Shinobu
   Murakami, Masahiro
   Kiyokawa, Machiko
   Kuwahara, Akira
   Yasui, Toshiyuki
   Irahara, Minoru
TI Neonatal LPS injection alters the body weight regulation systems of rats
   under non-stress and immune stress conditions
SO INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
LA English
DT Article
DE LPS; Leptin; IL-1 beta; TNF-alpha
ID HYPOTHALAMIC NEUROPEPTIDE-Y; PITUITARY-ADRENAL AXIS; LEPTIN LEVELS;
   CHALLENGE ALTERS; POTENTIAL ROLE; PLASMA LEPTIN; LIPOPOLYSACCHARIDE;
   ENDOTOXIN; EXPOSURE; EXPRESSION
AB It has been reported that prenatal immune stress induced by lipopolysaccharides or cytokines increases food intake and leads to obesity and other features of metabolic syndrome in adulthood. Using Sprague-Dawley rats, we evaluated whether neonatal LPS injection altered their body weight regulation systems under non-stress and immune stress conditions. On Day 10 after birth, all pups were injected with LPS (100 mu g/kg, i.p.) (PND10LPS) or saline (PND(10)Saline). After weaning, body weight was significantly elevated in PND10LPS compared with PND(10)Saline. Thereafter, the rats were injected with LPS (100 mu g/kg, i.p.) or saline (used as a basal condition) from 7 to 8 weeks of age. Under basal conditions, cumulative food intake were significantly higher, serum leptin concentration was significantly increased, and hypothalamic NPY mRNA expression was significantly decreased in PND10LPS compared with PND(10)Saline. Under adult LPS injected conditions, body weight gain and cumulative food intake were suppressed in both the PND10LPS and PND(10)Saline groups compared with those observed under basal adult saline-injected conditions. The suppressive effects induced by adult LPS injection were less evident in the PND10LPS group than in the PND(10)Saline group. Adult LPS injection increased the serum leptin concentration in the PND(10)Saline rats, but not in the PND10LPS rats. In addition, adult LPS injection increased the mRNA expression of anorexinergic factors (IL-1 beta, and TNF-alpha), and decreased that of the orexinergic factor NPY in both groups. However, the influence of adult LPS injection upon these factors was less evident in the PND10LPS group than in the PND(10)Saline group. These results suggest that neonatal LPS injection alters body weight regulation under both non-stress and immune stress conditions in male rats. Changes in the endocrine, neuropeptide, and cytokine regulation systems might be involved in these alterations. (C) 2009 ISDN. Published by Elsevier Ltd. All rights reserved.
C1 [Iwasa, Takeshi; Matsuzaki, Toshiya; Kinouchi, Riyo; Fujisawa, Shinobu; Murakami, Masahiro; Kiyokawa, Machiko; Kuwahara, Akira; Yasui, Toshiyuki; Irahara, Minoru] Univ Tokushima, Grad Sch, Inst Hlth Biosci, Dept Obstet & Gynecol, Tokushima 7708503, Japan.
C3 Tokushima University
RP Iwasa, T (corresponding author), Univ Tokushima, Grad Sch, Inst Hlth Biosci, Dept Obstet & Gynecol, Tokushima 7708503, Japan.
EM takeshi1@clin.med.tokushima-u.ac.jp
FU Grants-in-Aid for Scientific Research [21592100] Funding Source: KAKEN
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NR 38
TC 34
Z9 36
U1 0
U2 8
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0736-5748
EI 1873-474X
J9 INT J DEV NEUROSCI
JI Int. J. Dev. Neurosci.
PD FEB
PY 2010
VL 28
IS 1
BP 119
EP 124
DI 10.1016/j.ijdevneu.2009.08.015
PG 6
WC Developmental Biology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Developmental Biology; Neurosciences & Neurology
GA 565OQ
UT WOS:000275304000015
PM 19733650
DA 2025-06-11
ER

PT J
AU Zemel, MB
   Sun, XC
AF Zemel, Michael B.
   Sun, Xiaocun
TI Dietary calcium and dairy products modulate oxidative and inflammatory
   stress in mice and humans
SO JOURNAL OF NUTRITION
LA English
DT Article
ID CHAIN AMINO-ACIDS; ANGIOTENSIN-II; INTRACELLULAR CALCIUM;
   ADIPOSE-TISSUE; METABOLIC SYNDROME; HUMAN ADIPOCYTES; NAD(P)H OXIDASE;
   AGOUTI GENE; WEIGHT-LOSS; 1-ALPHA,25-DIHYDROXYVITAMIN D-3
AB We have recently shown 1 alpha,25-dihydroxycholecalciferol increased oxidative stress and inflammatory stress in vitro, whereas suppression of la,25-dihydroxycholecalciferol with dietary calcium (Ca) decreased oxidative and inflammatory stress in vivo. However, dairy products contains additional factors, such as angiotensin-converting enzyme inhibitors, which may further suppress oxidative and inflammatory stress. Accordingly, this study was designed to study the effects of the short-term (3 wk) basal suboptimal Ca (0.4%), high-Ca (1.2% from CaCO3), and high-dairy (1.2% Ca from milk) obesigeric diets on oxidative and inflammatory stress in adipocyte fatty acid-binding protein-agouti transgenic mice. Adipose tissue reactive oxygen species (ROS) production and NADPH oxidase mRNA and plasma malondialdehyde (MDA) were reduced by the high-Ca diet (P < 0.001) compared with the basal diet and ROS and MDA were further decreased by the high-dairy diet (P < 0.001). The high-Ca and -dairy diets also resulted in suppression of adipose tissue tumor necrosis factor a and interleukin (IL)-6 mRNA (P = 0.001) compared with the basal diet, whereas an inverse pattern was noted for adiponectin and IL-15 mRNA (P = 0.002). Consequently, we conducted a follow-up evaluation of adiponectin and C-reactive protein (CRP) in archival samples from 2 previous clinical trials conducted in obese men and women. Twenty-four weeks of feeding a high-dairy eucaloric diet and hypocaloric diet resulted in an 11 (P < 0.03) and 29% (P < 0.01) decrease in CRP, respectively (post-test vs. pre-test), whereas there was no significant change in the low-dairy groups. Adiponectin decreased by 8% in subjects fed the eucaloric high-dairy diet (P = 0.003) and 18% in those fed the hypocaloric high-dairy diet (P < 0.05). These data demonstrate that dietary Ca suppresses adipose tissue oxidative and inflammatory stress.
C1 [Zemel, Michael B.; Sun, Xiaocun] Univ Tennessee, Dept Nutr, Knoxville, TN 37996 USA.
C3 University of Tennessee System; University of Tennessee Knoxville
RP Zemel, MB (corresponding author), Univ Tennessee, Dept Nutr, Knoxville, TN 37996 USA.
EM mzemel@utk.edu
OI sun, xiaocun/0000-0003-3053-1518; Zemel, Michael/0000-0003-4104-5750
CR Atabek ME, 2004, J PEDIATR ENDOCR MET, V17, P1063
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NR 54
TC 128
Z9 147
U1 0
U2 6
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0022-3166
EI 1541-6100
J9 J NUTR
JI J. Nutr.
PD JUN
PY 2008
VL 138
IS 6
BP 1047
EP 1052
DI 10.1093/jn/138.6.1047
PG 6
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 301UK
UT WOS:000255920900010
PM 18492832
OA Bronze
DA 2025-06-11
ER

PT J
AU Bloomer, SA
   Olivier, AK
   Bergmann, OM
   Mathahs, MM
   Broadhurst, KA
   Hicsasmaz, H
   Brown, KE
AF Bloomer, Steven A.
   Olivier, Alicia K.
   Bergmann, Ottar M.
   Mathahs, M. Meleah
   Broadhurst, Kimberly A.
   Hicsasmaz, Hasan
   Brown, Kyle E.
TI Strain- and time-dependent alterations in hepatic iron metabolism in a
   murine model of nonalcoholic steatohepatitis
SO CELL BIOCHEMISTRY AND FUNCTION
LA English
DT Article
DE hemosiderosis; hepcidin; H-ferritin; inflammation; oxidative stress
ID DEFICIENT DIETARY MODEL; OXIDATIVE STRESS; INTERSTRAIN DIFFERENCES;
   REGULATORY PROTEIN; ATHEROGENIC DIET; GENE-EXPRESSION; LIVER FIBROSIS;
   MESSENGER-RNAS; HEPCIDIN; MICE
AB Nonalcoholic steatohepatitis is a common liver disease that is often accompanied by dysregulated iron metabolism. The aim of the study was to test the hypothesis that aberrant iron metabolism in nonalcoholic steatohepatitis is modulated by genetic susceptibility to inflammation and oxidative stress. Hepatic histology and iron content were assessed in 3 inbred strains of mice (C57BL/6, BALB/c, and C3H/HeJ) fed an atherogenic diet (AD). Hepatic expression of genes relevant to iron metabolism, inflammation, and oxidative stress were quantitated by real-time reverse transcription-polymerase chain reaction. At 6weeks on the AD, histologic injury and induction of inflammatory and oxidative stress-associated gene expression were most pronounced in C57BL/6. At 18weeks on the AD, these parameters were similar in C57BL/6 and BALB/c. Atherogenic diet-fed C3H/HeJ showed milder responses at both time points. The AD was associated with decreased hepatic iron concentrations in all strains at 6 and 18weeks. The decrease in hepatic iron concentrations did not correlate with changes in hepcidin expression and was not associated with altered expression of iron transporters. These findings are similar to those observed in models of obesity-induced steatosis and indicate that hepatic steatosis can be associated with depletion of iron stores that is not explained by upregulation of hepcidin expression by inflammation.
   Significance of the studyNonalcoholic steatohepatitis (NASH) is a common liver disease that often accompanies the metabolic syndrome. The latter condition has been linked to iron deficiency and diminished intestinal iron absorption, likely the result of hepcidin upregulation by chronic inflammation. Paradoxically, some NASH patients accumulate excess hepatic iron, which may increase fibrosis and cancer risk. Iron accumulation has been attributed to suppression of hepcidin by oxidative stress. The objective of this study was to investigate the contributions of inflammation and oxidative stress to altered hepatic iron metabolism in a murine model of NASH using inbred strains of mice with differing susceptibilities to injury.
C1 [Bloomer, Steven A.] Penn State Abington, Div Sci & Engn, Abington, PA USA.
   [Olivier, Alicia K.] Univ Iowa, Dept Pathol, Carver Coll Med, Div Comparat Pathol, Iowa City, IA 52242 USA.
   [Bergmann, Ottar M.; Brown, Kyle E.] Univ Iowa, Dept Internal Med, Carver Coll Med, Div Gastroenterol Hepatol, Iowa City, IA 52242 USA.
   [Mathahs, M. Meleah; Broadhurst, Kimberly A.; Brown, Kyle E.] Iowa City Vet Adm Med Ctr, Iowa City, IA USA.
   [Hicsasmaz, Hasan] Clear Peak LLC, Greenwood Village, CO USA.
   [Brown, Kyle E.] Univ Iowa, Carver Coll Med, Dept Radiat Oncol, Program Free Radical & Radiat Biol, Iowa City, IA USA.
   [Olivier, Alicia K.] Mississippi State Univ, Dept Pathobiol & Populat Med, Starkville, MS USA.
   [Bergmann, Ottar M.] Natl Univ Hosp Iceland, Sect Gastroenterol & Hepatol, Dept Internal Med, Reykjavik, Iceland.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE);
   Pennsylvania State University; University of Iowa; University of Iowa;
   University of Iowa; Mississippi State University; Landspitali National
   University Hospital
RP Brown, KE (corresponding author), Div Gastroenterol Hepatol, 4553 JCP,200 Hawkins Dr, Iowa City, IA 52242 USA.
EM kyle-brown@uiowa.edu
OI Brown, Kyle/0000-0002-8206-036X
FU American Association
FX American Association for the Study of Liver Diseases
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NR 61
TC 8
Z9 8
U1 0
U2 10
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0263-6484
EI 1099-0844
J9 CELL BIOCHEM FUNCT
JI Cell Biochem. Funct.
PD DEC
PY 2016
VL 34
IS 8
BP 628
EP 639
DI 10.1002/cbf.3238
PG 12
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA EF3ZL
UT WOS:000390263800012
PM 27935134
DA 2025-06-11
ER

PT J
AU Okin, PM
   Roman, MJ
   Best, LG
   Lee, ET
   Galloway, JM
   Howard, BV
   Devereux, RB
AF Okin, PM
   Roman, MJ
   Best, LG
   Lee, ET
   Galloway, JM
   Howard, BV
   Devereux, RB
TI C-reactive protein and electrocardiographic ST-segment depression
   additively predict mortality - The strong heart study
SO JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
LA English
DT Article
ID FUTURE CARDIOVASCULAR EVENTS; LEFT-VENTRICULAR HYPERTROPHY; METABOLIC
   SYNDROME; HYPERTENSIVE PATIENTS; AMERICAN-INDIANS; T ABNORMALITIES;
   STATIN THERAPY; STRAIN PATTERN; ALL-CAUSE; DISEASE
AB OBJECTIVES This study was designed to examine whether high-sensitivity C-reactive protein (CRP) and electrocardiographic (ECG) ST-segment depression (STD) have additive utility for predicting cardiovascular disease (CVD) death and all-cause death (ACD).
   BACKGROUND C-reactive protein, a marker of systemic inflammation, and ECG STD, an index of myocardial ischemia and hypertrophy, independently predict mortality.
   METHODS Electrocardiograms and CRP levels were examined in 2,155 American Indian participants in the second Strong Heart Study examination. ST-segment depression >= 50 mu V (n = 127) and CRP > 7.0 mg/l (defining the upper quartile of CRP levels, n = 540) were considered abnormal.
   RESULTS After 5.2 +/- 1.2 years follow-up there were 95 CVD deaths and 310 ACD. In univariate Cox analyses, the combination of CRP and ECG STD improved risk stratification compared to either alone, with the presence of both CRP > 7.0 and ECG STD associated with a 7.7-fold increased risk of CVD death (95% confidence interval [CI] 3.3 to 18.2) and a 6.5-fold increased risk of ACID (95% CI 4.1 to 10.3). After adjustment for age, gender, and relevant risk factors, the combination of high CRP and STD remained predictive of CVD death and ACID, with the presence of both abnormal CRP and STD associated with the highest risks of CVD death (hazard ratio [HR] 3.2, 95% CI 1.1 to 10.5) and ACD (HR 3.9, 95% CI 2.1 to 7.2) and the presence of either high CRP or abnormal STD associated with intermediate risks of CVD death (HR 2.2, 95% CI 1.4 to 3.4) and ACID (HR 1.5, 95% CI 1.2 to 2.0).
   CONCLUSIONS The combination of ECG STD and CRP increases the risk of mortality, demonstrating the additive impacts of active inflammation and preclinical CVD on prognosis. (c) 2005 by the American College of Cardiology Foundation
C1 Cornell Univ, Weill Med Coll, Dept Med, Div Cardiol, New York, NY 10021 USA.
   Missouri Breaks Ind Res Inc, Timber Lake, SD USA.
   Univ Oklahoma, Hlth Sci Ctr, Coll Publ Hlth, Oklahoma City, OK USA.
   Univ Arizona, Tucson, AZ USA.
   MedStar Res Inst, Washington, DC USA.
C3 Cornell University; Weill Cornell Medicine; Missouri Breaks Industries
   Research Inc.; University of Oklahoma System; University of Oklahoma
   Health Sciences Center; University of Arizona
RP Okin, PM (corresponding author), Cornell Univ, Weill Med Coll, Dept Med, Div Cardiol, 525 E 68th St, New York, NY 10021 USA.
EM pokin@med.cornell.edu
FU NCRR NIH HHS [M10RR0047-34] Funding Source: Medline; NHLBI NIH HHS
   [HL-41642, HL-41652, HL-65521, HL-41654] Funding Source: Medline
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NR 42
TC 11
Z9 11
U1 0
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0735-1097
J9 J AM COLL CARDIOL
JI J. Am. Coll. Cardiol.
PD JUN 7
PY 2005
VL 45
IS 11
BP 1787
EP 1793
DI 10.1016/j.jacc.2005.02.072
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 932ZJ
UT WOS:000229593000010
PM 15936607
DA 2025-06-11
ER

PT J
AU Dovinova, I
   Kvandova, M
   Balis, P
   Gresova, L
   Majzunova, M
   Horakova, L
   Chan, JYH
   Barancik, M
AF Dovinova, Ima
   Kvandova, Miroslava
   Balis, Peter
   Gresova, Linda
   Majzunova, Miroslava
   Horakova, Lubica
   Chan, Julie Y. H.
   Barancik, Miroslav
TI The Role of Nrf2 and PPAR. in the Improvement of Oxidative Stress in
   Hypertension and Cardiovascular Diseases
SO PHYSIOLOGICAL RESEARCH
LA English
DT Review
DE Nrf2; PPAR gamma; Oxidative stress; Redox regulation; Hypertension;
   Cardiovascular diseases
ID ROSTRAL VENTROLATERAL MEDULLA; NEUROGENIC HYPERTENSION; GAMMA;
   ACTIVATION; ANTIOXIDANT; MECHANISMS; PHOSPHORYLATION; DOXORUBICIN;
   PATHWAY; ROS
AB Reactive oxygen species are an important element of redox regulation in cells and tissues. During physiological processes, molecules undergo chemical changes caused by reduction and oxidation reactions. Free radicals are involved in interactions with other molecules, leading to oxidative stress. Oxidative stress works two ways depending on the levels of oxidizing agents and products. Excessive action of oxidizing agents damages biomolecules, while a moderate physiological level of oxidative stress (oxidative eustress) is necessary to control life processes through redox signaling required for normal cellular operation. High levels of reactive oxygen species (ROS) mediate pathological changes. Oxidative stress helps to regulate cellular phenotypes in physiological and pathological conditions. Nrf2 (nuclear factor erythroid 2-related factor 2, NFE2L2) transcription factor functions as a target nuclear receptor against oxidative stress and is a key factor in redox regulation in hypertension and cardiovascular disease. Nrf2 mediates transcriptional regulation of a variety of target genes. The Keap1-Nrf2-ARE system regulates many detoxification and antioxidant enzymes in cells after the exposure to reactive oxygen species and electrophiles. Activation of Nrf2/ARE signaling is differentially regulated during acute and chronic stress. Keap1 normally maintains Nrf2 in the cytosol and stimulates its degradation through ubiquitination. During acute oxidative stress, oxidized molecules modify the interaction of Nrf2 and Keap1, when Nrf2 is released from the cytoplasm into the nucleus where it binds to the antioxidant response element (ARE). This triggers the expression of antioxidant and detoxification genes. The consequence of long-term chronic oxidative stress is activation of glycogen synthase kinase 3 beta (GSK-3 beta) inhibiting Nrf2 activity and function. PPAR. (peroxisome proliferator-activated receptor gamma) is a nuclear receptor playing an important role in the management of cardiovascular diseases, hypertension and metabolic syndrome. PPAR gamma targeting of genes with peroxisome proliferator response element (PPRE) has led to the identification of several genes involved in lipid metabolism or oxidative stress. PPAR gamma stimulation is triggered by endogenous and exogenous ligands - agonists and it is involved in the activation of several cellular signaling pathways involved in oxidative stress response, such as the PI3K/Akt/NOS pathway. Nrf2 and PPAR. are linked together with their several activators and Nrf2/ARE and PPAR gamma/PPRE pathways can control several types of diseases.
C1 [Dovinova, Ima; Balis, Peter; Gresova, Linda; Majzunova, Miroslava; Horakova, Lubica; Barancik, Miroslav] Slovak Acad Sci, Ctr Expt Med, Bratislava, Slovakia.
   [Dovinova, Ima] Slovak Univ Technol Bratislava, Fac Chem & Food Technol, Intitute Biochem & Microbiol, Bratislava, Slovakia.
   [Kvandova, Miroslava] Johannes Gutenberg Univ Mainz, Ctr Cardiol, Cardiol 1, Med Ctr, Mainz, Germany.
   [Majzunova, Miroslava] Fac Nat Sci, Dept Anim Physiol & Ethol, Bratislava, Slovakia.
   [Chan, Julie Y. H.] Chang Gung Mem Hosp, Inst Translat Res Biomed, Kaohsiung, Taiwan.
C3 Slovak Academy of Sciences; Centre of Experimental Medicine, SAS; Slovak
   University of Technology Bratislava; Johannes Gutenberg University of
   Mainz; Comenius University Bratislava; Chang Gung Memorial Hospital
RP Dovinova, I (corresponding author), Slovak Acad Sci, Ctr Expt Med, Inst Normal & Pathol Physiol, Dubravska Cesta 9, Bratislava 84104, Slovakia.
EM ima.dovinova@savba.sk
RI Majzunova, Miroslava/JCE-6584-2023; Chan, Julie/X-5253-2019; Balis,
   Peter/AAS-3538-2021
OI Kvandova, Miroslava/0000-0002-7741-8283; Balis,
   Peter/0000-0001-9835-2941; Majzunova, Miroslava/0000-0001-8748-4279
FU  [APVV-18-0548];  [VEGA 2/0158/20];  [VEGA 2/0190/17]
FX The research behind this paper was supported by grant projects:
   APVV-18-0548, VEGA 2/0158/20 and VEGA 2/0190/17.
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NR 50
TC 36
Z9 39
U1 1
U2 22
PU ACAD SCIENCES CZECH REPUBLIC, INST PHYSIOLOGY
PI PRAGUE 4
PA VIDENSKA 1083, PRAGUE 4 142 20, CZECH REPUBLIC
SN 0862-8408
EI 1802-9973
J9 PHYSIOL RES
JI Physiol. Res.
PD SEP
PY 2020
VL 69
SU 4
BP S541
EP S553
DI 10.33549/physiolres.934612
PG 13
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA QM5SE
UT WOS:000621838200002
PM 33656904
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Ayeni, OA
   Joffe, M
   Cubasch, H
   Rinaldi, S
   Taljaard, C
   Vorster, E
   Romieu, I
   Norris, SA
AF Ayeni, O. A.
   Joffe, M.
   Cubasch, H.
   Rinaldi, S.
   Taljaard, C.
   Vorster, E.
   Romieu, I.
   Norris, S. A.
TI Prevalence of comorbidities in women with and without breast cancer in
   Soweto, South Africa: Results from the SABC study
SO SAMJ SOUTH AFRICAN MEDICAL JOURNAL
LA English
DT Article
ID PATIENT HEALTH QUESTIONNAIRE-9; NONCOMMUNICABLE DISEASES; METABOLIC
   SYNDROME; SURVIVAL; CARE; QUALITY; RISK; CHALLENGES; DEPRESSION;
   GUIDELINE
AB Background. Comorbidities occurring concurrently in breast cancer patients can be burdensome, as they may negatively influence time and stage of presentation.
   Objectives. To describe the comorbid health conditions among South African (SA) black women with and without breast cancer and to determine factors associated with advanced-stage presentation of breast cancer.
   Methods. A population-based case-control study on breast cancer was conducted in black women in Soweto, SA, the SABC (South Africa Breast Cancer) study. Lifestyle information and blood samples were collected from 399 women with histologically confirmed new cases of invasive primary breast cancer, recruited prior to any therapy, and 399 age-and neighbourhood-matched controls without breast cancer. We compared self-reported metabolic diseases, depression, anthropometric measurements, blood pressure, HIV status and point-of-care lipid and glucose levels between patients with breast cancer and the control group.
   Results. In the whole population, the mean (standard deviation) age was 54.6 (12.9) years, the majority (81.2%) of the participants were overweight or obese, 85.3% had abdominal adiposity, 61.3% were hypertensive, 47.1% had impaired fasting plasma glucose, 8.4% had elevated total cholesterol, 74.8% had low high-density lipoprotein and 10.9% were assessed to be depressed. Ninety-one percent of the whole cohort had at least one metabolic disease. In the breast cancer group, 72.2% had one or more metabolic diseases only (HIV-negative and no evidence of depression), compared with 64.7% of the control group. From a multivariate logistic regression adjusted model, higher household socioeconomic status conferred a 19% reduction in the odds of having advanced-stage breast cancer at diagnosis, while hypertension, dyslipidaemia and HIV were not significantly associated with stage at breast cancer diagnosis in the adjusted model.
   Conclusions. A large proportion of women experience several comorbidities, highlighting the need to address the chronic non-communicable disease epidemic in SA and to co-ordinate multidisciplinary primary-, secondary-and tertiary-level care in the country's complex healthcare system for better outcome.
C1 [Ayeni, O. A.; Joffe, M.; Norris, S. A.] Univ Witwatersrand, Fac Hlth Sci, Dept Paediat, SAMRC Wits Dev Pathways Hlth Res Unit, Johannesburg, South Africa.
   [Ayeni, O. A.; Joffe, M.; Cubasch, H.; Norris, S. A.] Wits Hlth Consortium Pty Ltd, Noncommunicable Dis Res Div, Johannesburg, South Africa.
   [Cubasch, H.] Univ Witwatersrand, Fac Hlth Sci, Dept Surg, Johannesburg, South Africa.
   [Rinaldi, S.; Romieu, I.] Int Agcy Res Canc, Sect Nutr & Metab, Lyon, France.
   [Taljaard, C.; Vorster, E.] North West Univ, Ctr Excellence Nutr, Potchefstroom Campus, Potchefstroom, South Africa.
   [Romieu, I.] Natl Inst Publ Hlth, Ctr Res Populat Hlth, Cuernavaca, Morelos, Mexico.
   [Romieu, I.] Emory Univ, Hubert Dept Global Hlth, Atlanta, GA 30322 USA.
C3 University of Witwatersrand; University of Witwatersrand; World Health
   Organization; International Agency for Research on Cancer (IARC); North
   West University - South Africa; Instituto Nacional de Salud Publica;
   Emory University
RP Ayeni, OA (corresponding author), Univ Witwatersrand, Fac Hlth Sci, Dept Paediat, SAMRC Wits Dev Pathways Hlth Res Unit, Johannesburg, South Africa.; Ayeni, OA (corresponding author), Wits Hlth Consortium Pty Ltd, Noncommunicable Dis Res Div, Johannesburg, South Africa.
EM oluwa.tosinayeni@yahoo.com
RI Taljaard, Christine/MIN-5424-2025; Norris, Shane/C-4664-2014
OI Norris, Shane/0000-0001-7124-3788; Joffe, Maureen/0000-0001-8616-9672;
   Taljaard-Krugell, Christine/0000-0001-9109-269X
FU World Cancer Research Fund; National Institutes of Health
   [NIH/R01-CA192627-01]; South African Medical Research Council/University
   of the Witwatersrand Common Epithelial Cancer Research Centre; Cancer
   Association of South Africa grant 'Down-staging and improving survival
   of breast cancer in South Africa'
FX This work was supported by: (i) the World Cancer Research Fund, (ii)
   National Institutes of Health grant NIH/R01-CA192627-01 to MJ, Dr Judith
   S Jacobson (Department of Epidemiology, Mailman School of Public Health,
   Columbia University, New York, USA) and Dr Alfred I Neugut (Herbert
   Irving Comprehensive Cancer Center, Department of Medicine and
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NR 59
TC 16
Z9 17
U1 0
U2 2
PU SA MEDICAL ASSOC
PI PRETORIA
PA BLOCK F CASTLE WALK CORPORATE PARK, NOSSOB STREET, ERASMUSKLOOF EXT3,
   PRETORIA, 0002, SOUTH AFRICA
SN 0256-9574
EI 2078-5135
J9 SAMJ S AFR MED J
JI SAMJ S. Afr. Med. J.
PD APR
PY 2019
VL 109
IS 4
BP 264
EP 271
DI 10.7196/SAMJ.2019.v109i4.13465
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA HR0XB
UT WOS:000462851200019
PM 31084693
OA Green Submitted, gold, Green Accepted
DA 2025-06-11
ER

PT J
AU Chen, C
   Wu, HF
   Yang, LK
   Kan, K
   Zhang, XP
   Zhang, S
   Jia, RF
   Li, X
AF Chen, Chen
   Wu, Hongfeng
   Yang, Likun
   Kan, Ke
   Zhang, Xinping
   Zhang, Su
   Jia, Rufu
   Li, Xian
TI Network analysis of chronic disease among middle-aged and older adults
   in China: a nationwide survey
SO FRONTIERS IN PUBLIC HEALTH
LA English
DT Article
DE multimorbidity; network analysis; random forest model; influencing
   factor; middle-aged and older people; China; CHARLS
ID PHYSICAL-ACTIVITY QUESTIONNAIRE; HEALTH; MULTIMORBIDITY; DEPRESSION;
   RELIABILITY; SYMPTOMS
AB Background Given the rising prevalence of chronic diseases and multimorbidity among middle-aged and older individuals in China, it is crucial to explore the patterns of chronic disease multimorbidity and uncover the underlying mechanisms driving the co-existence of multiple chronic conditions.Methods This study analyzed data from 19,206 participants in the China Health and Retirement Longitudinal Study (CHARLS 2018). The IsingFit model was used to build the chronic disease co-morbidity network, where nodes represented diseases and edges reflected conditionally independent partial correlations. Community detection identified groups of closely related diseases using the Louvain algorithm. Multivariable linear regression with forward stepwise selection explored factors influencing chronic disease co-morbidity. A random forest model ranked these factors by importance, providing insights into relationships and key contributors.Results This study identified the most frequent multimorbidity pairs in the middle-aged and older adult population as hypertension with arthritis, and digestive diseases with arthritis. Multimorbidities were classified into four subgroups: respiratory diseases, metabolic syndrome, neurological diseases, and digestive diseases. Heart disease showed centrality in the multimorbidity network, while memory-related diseases played a bridging role. Key factors associated with multimorbidity included age, gender, pain, sleep, physical activity, depression, and education. Random forest analysis revealed that age and pain had the greatest impact on multimorbidity development, offering insights for targeted prevention and management strategies.Conclusion This study systematically analyzed multimorbidity patterns and their influencing factors in the Chinese middle-aged and older adult population. The data were examined at three levels: overall network, key influencing factors, and individual characteristics. Cardio-metabolic diseases were identified as a core component of the multimorbidity network. Advanced age, pain, and depression were found to be independent risk factors affecting the number of multimorbidities, while healthy behaviors acted as significant protective factors. The study enhances understanding of multimorbidity mechanisms and provides a scientific basis for public health interventions, emphasizing the importance of behavioral modification, health education, and social support for high-risk groups.
C1 [Chen, Chen] Chengde Med Univ, Sch Nursing, Chengde, Peoples R China.
   [Chen, Chen; Li, Xian] Hebei Gen Hosp, Dept Med Dev, Shijiazhuang, Peoples R China.
   [Wu, Hongfeng] Hebei Gen Hosp, Supply Dept, Shijiazhuang, Peoples R China.
   [Yang, Likun] Hebei Gen Hosp, Wound & Stomy Clin, Shijiazhuang, Peoples R China.
   [Kan, Ke] HeBei Univ Chinese Med, Sch Nursing, Shijiazhuang, Peoples R China.
   [Zhang, Xinping] Hebei Childrens Hosp, Dept President, Shijiazhuang, Peoples R China.
   [Zhang, Su] Peking Univ Peoples Hosp, Dept Nursing, Beijing, Peoples R China.
   [Jia, Rufu] Cangzhou Cent Hosp, Dept Nursing, Cangzhou, Peoples R China.
C3 Chengde Medical University; Hebei University of Chinese Medicine
RP Li, X (corresponding author), Hebei Gen Hosp, Dept Med Dev, Shijiazhuang, Peoples R China.
EM lixian1966@126.com
RI Jia, Rufu/T-8558-2019
FX The author(s) declare that no financial support was received for the
   research and/or publication of this article.
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NR 47
TC 1
Z9 1
U1 11
U2 11
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 2296-2565
J9 FRONT PUBLIC HEALTH
JI Front. Public Health
PD APR 9
PY 2025
VL 13
AR 1551034
DI 10.3389/fpubh.2025.1551034
PG 14
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA 1SO0D
UT WOS:001472638600001
PM 40270733
DA 2025-06-11
ER

PT J
AU Azizoddin, DR
   Olmstead, R
   Anderson, KA
   Hirz, AE
   Irwin, MR
   Gholizadeh, S
   Weisman, M
   Ishimori, M
   Wallace, D
   Nicassio, P
AF Azizoddin, Desiree R.
   Olmstead, Richard
   Anderson, Kris-Ann
   Hirz, Alanna E.
   Irwin, Michael R.
   Gholizadeh, Shadi
   Weisman, Michael
   Ishimori, Mariko
   Wallace, Daniel
   Nicassio, Perry
TI Socioeconomic status, reserve capacity, and depressive symptoms predict
   pain in Rheumatoid Arthritis: an examination of the reserve capacity
   model
SO BMC RHEUMATOLOGY
LA English
DT Article
DE Rheumatoid arthritis; Pain; Socioeconomic factors; Psychosocial factors;
   Depressive symptoms
ID QUALITY-OF-LIFE; METABOLIC SYNDROME; COGNITIVE THERAPY;
   DISEASE-ACTIVITY; SOCIAL SUPPORT; HEALTH-STATUS; DISABILITY; RESOURCES;
   SELF; HELPLESSNESS
AB BackgroundGuided by the reserve capacity model, we evaluated the unique relationships between socioeconomic status (SES), reserve capacity (helplessness, self-efficacy, social support), and negative emotions on pain in patients with Rheumatoid Arthritis (RA).MethodsThe secondary analysis used baseline, cross-sectional data from 106 adults in a clinical trial comparing behavioral treatments for RA. Patients were eligible if they were >= 18 years old, met the ACR criteria for RA (determined by study rheumatologist), had stable disease and drug regimens for 3 months, and did not have a significant comorbid condition. Structural equation modeling evaluated the direct effects of SES, reserve capacity (helplessness- Arthritis Helplessness Index, self-efficacy -Personal Mastery Scale, social support- Social Provisions Scale) and negative emotions (stress and depressive symptoms- Perceived Stress Scale and Hamilton Depression Rating Scale) on pain (Rapid Assessment of Disease Activity in Rheumatology-RADAR & visual analog scale-VAS), and the indirect effects of SES as mediated by reserve capacity and negative emotions. The SEM model was evaluated using multiple fit criteria: chi 2 goodness-of-fit statistic, the comparative fit index (CFI), the standardized root mean square residual (SRMR), and the root mean square error of approximation (RMSEA).ResultsParticipants were mostly female (85%), 55.45 years old on average, self-identified as white (61%), Hispanic (16%), black (13%), and other (10%), and had RA for an average of 10.63 years. Results showed that low SES contributed to worse pain, through lower reserve capacity and higher negative emotions. Mediational analyses showed that reserve capacity and negative emotions partially mediated the effect of SES on pain. The final model explained 39% of the variance in pain.ConclusionsThe findings indicate that lower SES was related to worse clinical pain outcomes and negative emotions and reserve capacity (helplessness, social support, and self-efficacy) mediated the effect of SES on pain. A primary limitation is the small sample size; future studies should evaluate this model further in larger, longitudinal approaches. Interventions that target negative emotions in patients with low SES may facilitate better pain control with RA.Trial registrationclinicaltrials.gov NCT00072657 01/02/2004 20/03/2009.
C1 [Azizoddin, Desiree R.; Anderson, Kris-Ann] Univ Oklahoma, Hlth Promot Res Ctr, Stephenson Canc Ctr, Hlth Sci Ctr, 655 Res Pkwy Suite 4000, Oklahoma City, OK 73104 USA.
   [Azizoddin, Desiree R.] Dana Farber Canc Inst, Dept Psychosocial Oncol & Palliat Care, Boston, MA 02215 USA.
   [Olmstead, Richard; Irwin, Michael R.; Nicassio, Perry] Univ Calif Los Angeles, Jane & Terry Semel Inst Neurosci & Human Behav, Cousins Ctr Psychoneuroimmunol, UCLA Geffen Sch Med, Los Angeles, CA USA.
   [Hirz, Alanna E.] UCLA, Dept Community Sci, Fielding Sch Publ Hlth, Los Angeles, CA USA.
   [Gholizadeh, Shadi] Univ Calif San Diego, San Diego State Univ, San Diego Joint Doctoral Program Clin Psychol, San Diego, CA USA.
   [Weisman, Michael; Ishimori, Mariko; Wallace, Daniel] Cedars Sinai Med Ctr, Div Rheumatol, Los Angeles, CA USA.
C3 University of Oklahoma System; University of Oklahoma Health Sciences
   Center; Harvard University; Harvard University Medical Affiliates;
   Dana-Farber Cancer Institute; University of California System;
   University of California Los Angeles; University of California Los
   Angeles Medical Center; David Geffen School of Medicine at UCLA;
   University of California System; University of California Los Angeles;
   University of California System; University of California San Diego;
   California State University System; San Diego State University; Cedars
   Sinai Medical Center
RP Azizoddin, DR (corresponding author), Univ Oklahoma, Hlth Promot Res Ctr, Stephenson Canc Ctr, Hlth Sci Ctr, 655 Res Pkwy Suite 4000, Oklahoma City, OK 73104 USA.; Azizoddin, DR (corresponding author), Dana Farber Canc Inst, Dept Psychosocial Oncol & Palliat Care, Boston, MA 02215 USA.
EM Desiree-Azizoddin@ouhsc.edu
RI Hirz, Alanna/HOF-3843-2023; Ishimori, Mariko/AAI-1401-2021
OI Anderson, Kris-Ann S./0000-0002-4838-9305
FU National Institutes of Health- National Institute of Arthritis and
   Musculoskeletal and Skin Diseases
FX The authors wish to acknowledge Mara Custodio, Kate Jackson and Sarosh
   J. Motivala who contributed to the diagnostic evaluation and assessment
   of study participants.
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NR 63
TC 2
Z9 2
U1 0
U2 2
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
EI 2520-1026
J9 BMC RHEUMATOL
JI BMC Rheumatol.
PD SEP 20
PY 2024
VL 8
IS 1
AR 46
DI 10.1186/s41927-024-00416-4
PG 10
WC Rheumatology
WE Emerging Sources Citation Index (ESCI)
SC Rheumatology
GA G4N9T
UT WOS:001316437200001
PM 39304956
OA gold
DA 2025-06-11
ER

PT J
AU Lara, E
   Koyanagi, A
   Olaya, B
   Lobo, A
   Miret, M
   Tyrovolas, S
   Ayuso-Mateos, JL
   Haro, JM
AF Lara, Elvira
   Koyanagi, Ai
   Olaya, Beatriz
   Lobo, Antonio
   Miret, Marta
   Tyrovolas, Stefanos
   Luis Ayuso-Mateos, Jose
   Maria Haro, Josep
TI Mild cognitive impairment in a Spanish representative sample: prevalence
   and associated factors
SO INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
LA English
DT Article
DE mild cognitive impairment; prevalence; risk factors; dementia;
   population-based study
ID LATE-LIFE DEPRESSION; BODY-MASS INDEX; ALZHEIMERS-DISEASE; METABOLIC
   SYNDROME; PHYSICAL-ACTIVITY; OLDER-ADULTS; RISK-FACTOR; DEMENTIA;
   METAANALYSIS; DECLINE
AB Objective: Given the limitations of treatments for dementia, the characterisation of the early stages of dementia is crucial for the development of preventive programmes and interventions. We aimed to estimate the prevalence of mild cognitive impairment (MCI) and examine its medical and lifestyle correlates in a nationally representative sample of the Spanish population.
   Methods: A total of 3625 participants (>= 50 years of age) were interviewed in a cross-sectional study. MCI was defined as the presence of cognitive concerns, the objective evidence of impairment in one or more cognitive domains, the preservation of independence in functional abilities and no dementia. Participants were also asked to provide sociodemographic, health status and lifestyle information. Logistic regression analyses were performed using the overall sample and by age groups.
   Results: The overall prevalence of MCI was 9.6%, with higher rates in older people and women. In the overall model, after adjustment for potential confounders, depression [odds ratio (OR) = 1.79; 95% confidence interval (CI) = 1.21, 2.66], diabetes (OR = 1.43; 95% CI = 1.05, 1.95), sleep disturbances (OR = 1.66; 95% CI = 1.09, 2.55) and low level of physical activity (OR = 1.71; 95% CI = 1.26, 2.31) were associated with significantly higher odds for MCI. When stratified by age groups, depression (OR = 2.41; 95% CI = 1.35, 4.31), stroke (OR = 3.77; 95% CI = 1.44, 9.83) and obesity (OR = 2.06; 95% CI = 1.20, 3.53) were significantly associated with MCI in middle-aged participants (50-64 years), whereas low level of physical activity (OR = 1.85; 95% CI = 1.32, 2.59) and sleep disturbances (OR = 1.79; 95% CI = 1.05, 3.05) were associated with MCI in individuals aged 65+ years.
   Conclusions: Significant associations between MCI and psychological, cardiovascular and lifestyle factors were found. Targeting modifiable risk factors might reduce the risk for MCI and subsequent dementia.
C1 [Lara, Elvira; Koyanagi, Ai; Olaya, Beatriz; Tyrovolas, Stefanos; Maria Haro, Josep] Parc Sanitari St Joan Deu, Barcelona, Spain.
   [Lara, Elvira; Koyanagi, Ai; Olaya, Beatriz; Lobo, Antonio; Miret, Marta; Tyrovolas, Stefanos; Luis Ayuso-Mateos, Jose; Maria Haro, Josep] CIBERSAM, Ctr Invest Biomed Red Salud Mental, Inst Salud Carlos III, Madrid, Spain.
   [Lara, Elvira; Maria Haro, Josep] Univ Barcelona, Fac Med, Barcelona, Spain.
   [Lobo, Antonio] Univ Zaragoza, Dept Med & Psychiat, Psychiat Serv, Hosp Clin Univ, Zaragoza, Spain.
   [Miret, Marta; Luis Ayuso-Mateos, Jose] Univ Autonoma Madrid, Dept Psychiat, Madrid, Spain.
   [Miret, Marta; Luis Ayuso-Mateos, Jose] Hosp Univ La Princesa, Dept Psychiat, Inst Invest Sanitaria Princesa IP, Madrid, Spain.
C3 Instituto de Salud Carlos III; CIBER - Centro de Investigacion Biomedica
   en Red; CIBERSAM; University of Barcelona; University of Zaragoza;
   Autonomous University of Madrid
RP Haro, JM (corresponding author), Parc Sanitari St Joan Deu, Barcelona, Spain.; Haro, JM (corresponding author), CIBERSAM, Ctr Invest Biomed Red Salud Mental, Inst Salud Carlos III, Madrid, Spain.; Haro, JM (corresponding author), Univ Barcelona, Fac Med, Barcelona, Spain.
EM jmharo@pssjd.org
RI Olaya, Beatriz/AAB-1952-2020; Tyrovolas, Stefanos/M-2758-2014; Di Carlo,
   Antonio/AAB-9776-2022; Haro, Josep Maria/D-1423-2011; Koyanagi,
   Ai/D-3833-2018; Miret, Marta/C-6103-2019
OI Ayuso-Mateos, Jose Luis/0000-0002-7544-826X; Koyanagi,
   Ai/0000-0002-9565-5004; Miret, Marta/0000-0003-3252-854X; Lara,
   Elvira/0000-0002-7424-2198
FU Spanish Ministry of Education, Culture and Sports [FPU13/03573];
   Instituto de Salud Carlos III (Spain) [CD12/00429]; Miguel Servet
   contract [CP13/00150]; ISCIII-General Branch Evaluation and Promotion of
   Health Research; European Regional Development Fund (ERDF-FEDER);
   Foundation for Education and European Culture (IPEP); European Community
   [223071]; Instituto de Salud Carlos III-FIS [PS09/00295, PS09/01845];
   Spanish Ministry of Science and Innovation ACI-Promociona
   [ACI2009-1010]; Centro de Investigacion Biomedica en Red de Salud Mental
   (CIBERSAM); Instituto de Salud Carlos III
FX Elvira Lara's work is supported by the FPU predoctoral grant
   (FPU13/03573) from the Spanish Ministry of Education, Culture and
   Sports. Beatriz Olaya's work is supported by the Sara Borrell
   postdoctoral programme (CD12/00429) from the Instituto de Salud Carlos
   III (Spain). Ai Koyanagi's work is supported by the Miguel Servet
   contract financed by the CP13/00150 project, integrated into the
   National R+D+I and funded by the ISCIII-General Branch Evaluation and
   Promotion of Health Research-and the European Regional Development Fund
   (ERDF-FEDER). Stefanos Tyrovolas received a scholarship from the
   Foundation for Education and European Culture (IPEP) to undertake his
   postdoctoral research, of which this work is a part. The research
   leading to these results received funding from the European Community's
   Seventh Framework Programme (FP7/2007-2013) under grant agreement number
   223071 (COURAGE in Europe), the Instituto de Salud Carlos III-FIS
   (research grant numbers PS09/00295 and PS09/01845) and the Spanish
   Ministry of Science and Innovation ACI-Promociona (ACI2009-1010). The
   study was supported by the Centro de Investigacion Biomedica en Red de
   Salud Mental (CIBERSAM) and Instituto de Salud Carlos III.
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NR 50
TC 67
Z9 71
U1 1
U2 24
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0885-6230
EI 1099-1166
J9 INT J GERIATR PSYCH
JI Int. J. Geriatr. Psychiatr.
PD AUG
PY 2016
VL 31
IS 8
BP 858
EP 867
DI 10.1002/gps.4398
PG 10
WC Geriatrics & Gerontology; Gerontology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Psychiatry
GA DV5IB
UT WOS:000382959400003
PM 26923809
DA 2025-06-11
ER

PT J
AU Brandao, GVC
   Pereira, EG
   Haddad, GR
   Miot, LDB
   Marques, SA
   Miot, HA
AF Brandao, Giovana Viotto Cagnon
   Pereira, Elizandra Gomes
   Haddad, Gabriela Roncada
   Miot, Luciane Donida Bartoli
   Marques, Silvio Alencar
   Miot, Helio Amante
TI Clinical characterization, physical frailty, and depression in elderly
   patients with psoriasis from a reference center in Brazil: a
   cross-sectional study
SO ANAIS BRASILEIROS DE DERMATOLOGIA
LA English
DT Article
DE Aged; Chronic disease; Immunosenescence; Metabolic syndrome; Psoriasis
ID CARDIOVASCULAR RISK-FACTORS; PREVALENCE; COMORBIDITIES; DYSLIPIDEMIA;
   CYTOKINES; INVENTORY; SEVERITY; HEALTH; PASI
AB Background: There are few studies dedicated to the characterization of the geriatric population with psoriasis, which has particularities in terms of clinical manifestations and therapeutic limitations. As psoriasis is a chronic disease, presenting a higher prevalence with age, the increase in life expectancy in Brazil demands knowledge about the behavior of the disease among the elderly.
   Objectives: To characterize elderly people with psoriasis from a tertiary service, from the clinical-epidemiological point of view, presence of comorbidities, physical frailty, and affective impact, and to compare these aspects with adults with psoriasis and elderly people without the disease.
   Methods: Cross-sectional study of 64 elderly patients with psoriasis, 64 adults with psoriasis, and 64 elderly patients without the disease. Clinical-demographic aspects, the Beck depression scale, and Skindex-16 were evaluated. Indicators of physical frailty were evaluated in elderly patients: handgrip, sit-to-stand test, fatigue, and weight loss >5%.
   Results: In the elderly, the mean age (SD) of psoriasis onset was 44 (10) years, men represented 47% of the sample, the prevalence of arthritis was 22%, and ungual involvement occurred in 72%. Topical corticosteroids were used more often among elderly people with psoriasis (100%) than among adults with the disease (86%), with no difference among other systemic treatments. Diabetes mellitus occurred in 30% of the elderly. Hypertension (59%), dyslipidemia (52%), depression (34%), and fatigue (59%) were more prevalent among the elderly with psoriasis than among the healthy controls.
   Study limitations: The study was carried out in a public reference service for patients with psoriasis, all of which were undergoing treatment.
   Conclusions: Elderly people with psoriasis from a tertiary service showed greater affective impairment, metabolic comorbidities, and physical frailty than elderly controls. (c) 2023 Sociedade Brasileira de Dermatologia. Published by Elsevier Espana, S.L.U. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
C1 [Brandao, Giovana Viotto Cagnon; Pereira, Elizandra Gomes; Haddad, Gabriela Roncada; Miot, Luciane Donida Bartoli; Marques, Silvio Alencar; Miot, Helio Amante] Univ Estadual Paulista, Fac Med, Dept Infectol Dermatol Diagnost Imagem & Radioter, Botucatu, SP, Brazil.
C3 Universidade Estadual Paulista
RP Miot, HA (corresponding author), Univ Estadual Paulista, Fac Med, Dept Infectol Dermatol Diagnost Imagem & Radioter, Botucatu, SP, Brazil.
EM heliomiot@gmail.com
RI Miot, Helio/HHZ-5121-2022; Marques, Silvio/A-4046-2009; Roncada Haddad,
   Gabriela/F-8057-2019; Miot, Helio Amante/F-6744-2012
OI Marques, Silvio/0000-0002-5512-4700; Roncada Haddad,
   Gabriela/0000-0002-7516-9586; Gomes Pereira,
   Elizandra/0000-0003-0683-0024; Miot, Helio Amante/0000-0002-2596-9294;
   Miot, Luciane/0000-0002-2388-7842; Cagnon, Giovana/0000-0003-2785-8018
FU FAPESP [19/06684-5]
FX FAPESP (project number 19/06684-5) .
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   Wu JJ, 2022, J EUR ACAD DERMATOL, V36, P797, DOI 10.1111/jdv.18044
   Yamazaki F, 2021, J DERMATOL, V48, P732, DOI 10.1111/1346-8138.15840
NR 55
TC 2
Z9 2
U1 0
U2 2
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0365-0596
EI 1806-4841
J9 AN BRAS DERMATOL
JI An. Brasil. Dermatol.
PD JAN-FEB
PY 2024
VL 99
IS 1
BP 19
EP 26
DI 10.1016/j.abd.2023.01.001
EA JAN 2024
PG 8
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA GP6K9
UT WOS:001153909400001
PM 37612180
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Kirton, R
   Sandford, I
   Raffan, E
   Hallsworth, S
   Burman, OHP
   Morgan, R
AF Kirton, Roxane
   Sandford, Imogen
   Raffan, Eleanor
   Hallsworth, Sarah
   Burman, Oliver H. P.
   Morgan, Ruth
TI The impact of restricted grazing systems on the behaviour and welfare of
   ponies
SO EQUINE VETERINARY JOURNAL
LA English
DT Article
DE grazing; horse; obesity; weight loss; welfare
ID EQUINE METABOLIC SYNDROME; LOW-INTENSITY EXERCISE; WEIGHT-LOSS; DIETARY
   RESTRICTION; HORSES; MANAGEMENT; PATTERNS; AGGRESSION
AB Background: Equine obesity is a growing concern. Much of the current management advice centres on dietary restrictions, including the removal or limitation of grazing. Little is known about the impact of these approaches on the welfare of the horse. Objective: This study investigates the effect of two commonly used grazing systems advocated for the control of weight-the 'strip-grazing' and the 'track' systems-on the behaviour and welfare of outdoor-living ponies. Study design: A within-subject cross-over experimental design with four groups of pasture-kept ponies experiencing each system for 4 weeks in a random order. Methods: Time budgets and behavioural indicators of welfare were measured using 24-h electronic surveillance, morphometric parameters including weight, body condition score and cresty neck score were measured weekly and activity levels were tracked. The effect of grazing system on movement and behaviour was tested using a general linear model. Results: Ponies moved more [median (IQR) % time spent moving, track: 3.23% (2.08%), strip: 2.02% (0.90%); p = 0.001] and travelled a greater distance [median (IQR) metres/24 h, track: 7013.47 m (1761.49 m), strip: 5331.91 m (494.16 m); p < 0.001] and engaged in less overt agonistic behaviour on the track system compared with the strip system [median (IQR) prevalence per hour; track: 0.14 (0.30), strip: 0.21 (0.37) p = 0.02]. Main limitations: A relatively short time period of exposure to each grazing system. Conclusions: Ponies on strip systems moved less and exhibited increased agonistic interactions compared with the track system, maybe as a result of a perceived reduction in space or concentration of resources, although the accessible areas were matched. These results suggest that there may be physical as well as psychological health benefits to the track system.
C1 [Kirton, Roxane; Hallsworth, Sarah] Redwings Horse Sanctuary, Norwich, England.
   [Kirton, Roxane; Burman, Oliver H. P.] Univ Lincoln, Sch Life & Environm Sci, Joseph Banks Labs, Lincoln, England.
   [Sandford, Imogen; Raffan, Eleanor] Univ Cambridge, Dept Physiol Dev & Neurosci, Cambridge, England.
   [Morgan, Ruth] Scotlands Rural Coll, RoslinInstitute Bldg, Easter Bush Campus, Edinburgh EH25 9RG, Scotland.
   [Morgan, Ruth] Univ Edinburgh, Royal Dick Sch Vet Studies, Roslin, Scotland.
C3 University of Lincoln; University of Cambridge; Scotland's Rural
   College; University of Edinburgh
RP Morgan, R (corresponding author), Scotlands Rural Coll, RoslinInstitute Bldg, Easter Bush Campus, Edinburgh EH25 9RG, Scotland.
EM ruth.morgan@sruc.ac.uk
RI Morgan, Ruth/JXX-8276-2024
OI Morgan, Ruth/0000-0003-1117-2273
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NR 48
TC 3
Z9 3
U1 2
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0425-1644
EI 2042-3306
J9 EQUINE VET J
JI Equine Vet. J.
PD MAY
PY 2025
VL 57
IS 3
BP 737
EP 744
DI 10.1111/evj.14411
EA SEP 2024
PG 8
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA 1GM0I
UT WOS:001312055400001
PM 39275860
OA Green Submitted, hybrid
DA 2025-06-11
ER

PT J
AU Seguella, L
   Corpetti, C
   Lu, J
   Pesce, M
   Franzin, SB
   Palenca, I
   Zilli, A
   Vincenzi, M
   Caprioli, D
   Paytuví-Gallart, A
   Sanseverino, W
   Rurgo, S
   Sarnelli, G
   Esposito, G
AF Seguella, Luisa
   Corpetti, Chiara
   Lu, Jie
   Pesce, Marcella
   Franzin, Silvia Basili
   Palenca, Irene
   Zilli, Aurora
   Vincenzi, Martina
   Caprioli, Daniele
   Paytuvi-Gallart, Andreu
   Sanseverino, Walter
   Rurgo, Sara
   Sarnelli, Giovanni
   Esposito, Giuseppe
TI Oleoylethanolamide-producing Lactobacillus paracasei
   F19 improves metabolic and behavioral disorders by restoring
   intestinal permeability and microbiota-gut-brain axis in high-fat
   diet-induced obese male mice
SO BRAIN BEHAVIOR AND IMMUNITY
LA English
DT Article
DE Oleoylethanolamine; Engineered probiotics; Metabolic syndrome;
   Microbiota; Behavioral disorders; Leaky-gut; Gut-brain axis
ID MOUSE MODEL; OLEOYLETHANOLAMIDE; INGESTION; PROFILE; IMPACT; ACID
AB Metabolic and mood disorders elicited by chronic exposure of high-fat diet (HFD) are often associated with intestinal dysbiosis and persistent low-grade inflammation in the small intestine. This leads to remodeling of the epithelial barrier with disruption of the neuroepithelial circuits that control energy homeostasis by the gut-brain axis. Therefore, therapies that restoreintestinal microbial niche and barrier function are promising candidates to counter peripheral metabolic challenges that affect behaviors controlled by the brain. The endogenous oleoylethanolamine (OEA) was found to shape the intestinal microbiota profile towards a "lean-like phenotype", ameliorating pathological profiles of metabolic diseases. Further, OEA displays beneficial effects in several cognitive paradigms and preserves the epithelial barrier integrity, acting as an intestinal "gate-keeper". Here, we developed an "intestinal OEA factory" for the in-situ and controlled release of OEA by using a probiotic-based delivery system. We engineered the Lactobacillus paracasei F19 (LP) to express the human N-acylphosphatidylethanolamine-preferring phospholipase D (NAPEpld) gene and to produce OEA in response to dietary ultra-low oleate supply. We treated 12-week HFD male mice with oleate-probiotic formulations and assessed their impact on metabolic and behavioral dysfunctions, and microbiota-gut-brain signaling after 8 weeks of treatment. NAPEexpressing LP (pNAPE-LP) led to significant reduced weight loss and improved metabolic dysfunction in HFDtreated mice. Further, a parallel improvement in depressive- and anxiety-like phenotypes was associated with the duodenal barrier function retrieval, the restoration of the Firmicutes/Bacteroidetes ratio, and an increase in beneficial bacteria, such as Lactobacillus, Prevotella, and Parabacteroides. The HFD-driven changes both in the enteric and central nervous system were prevented by pNAPE-LP/oleate treatment. Collectively, our data suggest that these effects were mediated by the oleate-dependent release of OEA by pNAPE-LP since no significant effects were observed in HFD mice treated with the native probiotic alone (pLP). This oleate-regulated delivery system of OEA is a safe and efficient probiotic-based strategy for the treatment of metabolic syndrome and related behavioral disorders.
C1 [Seguella, Luisa; Corpetti, Chiara; Franzin, Silvia Basili; Palenca, Irene; Zilli, Aurora; Vincenzi, Martina; Caprioli, Daniele; Esposito, Giuseppe] Sapienza Univ Rome, Dept Physiol & Pharmacol V Erspamer, Piazzale Aldo Moro 5, I-00185 Rome, Italy.
   [Pesce, Marcella; Rurgo, Sara; Sarnelli, Giovanni] Univ Naples Federico II, Dept Clin Med & Surg, Via Pansini 5, I-80131 Naples, Italy.
   [Lu, Jie] China Med Univ, Dept Anat & Cell Biol, 77 Puhe Rd, Shenyang, Liaoning, Peoples R China.
   [Paytuvi-Gallart, Andreu; Sanseverino, Walter] Sequentia Biotech SL, Carrer Dr Trueta 179, Barcelona 08005, Spain.
C3 Sapienza University Rome; University of Naples Federico II; China
   Medical University
RP Sarnelli, G (corresponding author), Univ Naples Federico II, Dept Clin Med & Surg, Via Pansini 5, I-80131 Naples, Italy.
EM luisa.seguella@uniroma1.it; chiara.corpetti@uniroma1.it;
   lvjie@cmu.edu.cn; marcella.pesce@unina.it;
   silvia.basilifranzin@uniroma1.it; irene.palenca@uniroma1.it;
   aurora.zilli@uniroma1.it; martina.vincenzi@uniroma1.it;
   daniele.caprioli@uniroma1.it; apaytuvi@sequentiabiotech.com;
   wsanseverino@sequentiabiotech.com; sara.rurgo@unina.it;
   sarnelli@unina.it; giuseppe.esposito@uniroma1.it
RI Seguella, Luisa/JCD-8038-2023; Pesce, Marcella/ABD-6001-2020; VINCENZI,
   MARTINA/HNR-1075-2023; Sanseverino, Walter/AAX-5254-2021;
   Paytuví-Gallart, Andreu/E-3967-2019
OI Sarnelli, Giovanni/0000-0002-1467-1134; Esposito,
   Giuseppe/0000-0001-8080-8218
FU PRIN [2022 - B53D23021090001]; MUR [LX5875]
FX PRIN 2022 - B53D23021090001 to LS and partially supported from MUR (PRIN
   2022; LX5875) to GS
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NR 69
TC 2
Z9 2
U1 7
U2 7
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0889-1591
EI 1090-2139
J9 BRAIN BEHAV IMMUN
JI Brain Behav. Immun.
PD JUL
PY 2025
VL 127
BP 25
EP 44
DI 10.1016/j.bbi.2025.02.014
EA MAR 2025
PG 20
WC Immunology; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Neurosciences & Neurology; Psychiatry
GA Z7H8V
UT WOS:001440580700001
PM 39988008
OA hybrid
DA 2025-06-11
ER

PT J
AU Misiak, B
   Piotrowski, P
   Beszlej, JA
   Kalinowska, S
   Chec, M
   Samochowiec, J
AF Misiak, Blazej
   Piotrowski, Patryk
   Beszlej, Jan Aleksander
   Kalinowska, Sylwia
   Chec, Magdalena
   Samochowiec, Jerzy
TI Metabolic Dysregulation and Psychosocial Stress in Patients with
   Schizophrenia Spectrum Disorders: A Case-Control Study
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Article
DE psychosis; physical health; hormone; metabolic syndrome; obesity
ID C-REACTIVE PROTEIN; BODY-MASS INDEX; 1ST-EPISODE PSYCHOSIS; CHILDHOOD
   MALTREATMENT; COPING STYLES; 1ST EPISODE; LIFE EVENTS; RISK;
   METAANALYSIS; RELIABILITY
AB Patients with schizophrenia spectrum disorders have a reduced life expectancy, which is largely the consequence of a high co-occurrence of cardiovascular diseases. To date, several intrinsic and environmental factors underlying this phenomenon have been found. However, the association with psychosocial stress has not been extensively addressed. In this study, we tested the relationship between a history of adverse childhood experiences (ACEs), lifetime stressors, perceived stress and metabolic parameters in patients with schizophrenia spectrum disorders and in healthy controls. The participants included 85 inpatients with schizophrenia spectrum disorders and 56 healthy controls. Serum levels of glucose, insulin, low- and high-density lipoproteins (LDL and HDL), triglycerides, total cholesterol and high-sensitivity C-reactive protein (hsCRP) were determined. After adjustment for potential confounding factors, patients had significantly higher levels of glucose (F = 4.856, p = 0.030), triglycerides (F = 4.720, p = 0.032) and hsCRP (F = 7.499, p = 0.007) as well as significantly lower levels of HDL (F = 5.300, p = 0.023) compared to healthy controls. There were also significant effects of interactions between diagnosis and a history of ACEs on the levels of insulin (F = 4.497, p = 0.036) and homeostatic model assessment of insulin resistance (HOMA-IR) (F = 3.987, p = 0.048). More specifically, the levels of insulin and HOMA-IR were significantly higher in the subgroup of patients with schizophrenia spectrum disorders and a positive history of ACEs compared to other subgroups of participants. No significant associations between lifetime stressors and perceived stress with metabolic parameters were found. Our findings indicate that a history of ACEs might be associated with insulin resistance in patients with schizophrenia spectrum disorders. Therapeutic strategies targeting early-life stress should be considered with early interventions that aim to manage cardiometabolic comorbidity in patients with schizophrenia spectrum disorders.
C1 [Misiak, Blazej; Piotrowski, Patryk; Beszlej, Jan Aleksander] Wroclaw Med Univ, Dept Psychiat, Pasteura 10 St, PL-50367 Wroclaw, Poland.
   [Kalinowska, Sylwia; Samochowiec, Jerzy] Pomeranian Med Univ, Dept Psychiat, Broniewskiego 26, PL-71460 Wroclaw, Poland.
   [Chec, Magdalena] Univ Szczecin, Inst Psychol, Dept Clin Psychol, Krakowska 69 St, PL-71017 Szczecin, Poland.
C3 Wroclaw Medical University; Pomeranian Medical University; University of
   Szczecin
RP Misiak, B (corresponding author), Wroclaw Med Univ, Dept Psychiat, Pasteura 10 St, PL-50367 Wroclaw, Poland.
EM blazej.misiak@umed.wroc.pl; patryk.piotrowski@umed.wroc.pl;
   jabeszlej@gmail.com; kalisy@onet.eu; magda.chec@gmail.com;
   samoj@pum.edu.pl
RI Misiak, Błażej/ABA-2657-2021; Samochowiec, Jerzy/G-8175-2014;
   Piotrowski, Patryk/ABD-4063-2021
OI Misiak, Blazej/0000-0002-5392-6398; Kalinowska,
   Sylwia/0000-0003-1715-3866; Samochowiec, Jerzy/0000-0003-1438-583X;
   Piotrowski, Patryk/0000-0001-7208-0562; Beszlej, Jan
   Aleksander/0000-0003-1257-6923
FU Iuventus Plus grant - Ministry of Science and Higher Education [IP2015
   052474]; OPUS grant - National Science Centre [2018/31/B/NZ5/00527]
FX This study was funded from the following grants: the Iuventus Plus grant
   awarded by the Ministry of Science and Higher Education (grant number:
   IP2015 052474) and the OPUS grant awarded by National Science Centre
   (grant number: 2018/31/B/NZ5/00527).
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NR 49
TC 10
Z9 10
U1 0
U2 7
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD DEC
PY 2020
VL 9
IS 12
AR 3822
DI 10.3390/jcm9123822
PG 10
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA PJ8FI
UT WOS:000601995800001
PM 33255883
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Homuth, G
   Wahl, S
   Müller, C
   Schurmann, C
   Mäder, U
   Blankenberg, S
   Carstensen, M
   Dörr, M
   Endlich, K
   Englbrecht, C
   Felix, SB
   Gieger, C
   Grallert, H
   Herder, C
   Illig, T
   Kruppa, J
   Marzi, CS
   Mayerle, J
   Meitinger, T
   Metspalu, A
   Nauck, M
   Peters, A
   Rathmann, W
   Reinmaa, E
   Rettig, R
   Roden, M
   Schillert, A
   Schramm, K
   Steil, L
   Strauch, K
   Teumer, A
   Völzke, H
   Wallaschofski, H
   Wild, PS
   Ziegler, A
   Völker, U
   Prokisch, H
   Zeller, T
AF Homuth, Georg
   Wahl, Simone
   Mueller, Christian
   Schurmann, Claudia
   Maeder, Ulrike
   Blankenberg, Stefan
   Carstensen, Maren
   Doerr, Marcus
   Endlich, Karlhans
   Englbrecht, Christian
   Felix, Stephan B.
   Gieger, Christian
   Grallert, Harald
   Herder, Christian
   Illig, Thomas
   Kruppa, Jochen
   Marzi, Carola S.
   Mayerle, Julia
   Meitinger, Thomas
   Metspalu, Andres
   Nauck, Matthias
   Peters, Annette
   Rathmann, Wolfgang
   Reinmaa, Eva
   Rettig, Rainer
   Roden, Michael
   Schillert, Arne
   Schramm, Katharina
   Steil, Leif
   Strauch, Konstantin
   Teumer, Alexander
   Voelzke, Henry
   Wallaschofski, Henri
   Wild, Philipp S.
   Ziegler, Andreas
   Voelker, Uwe
   Prokisch, Holger
   Zeller, Tanja
TI Extensive alterations of the whole-blood transcriptome are associated
   with body mass index: results of an mRNA profiling study involving two
   large population-based cohorts
SO BMC MEDICAL GENOMICS
LA English
DT Article
DE Transcriptomics; Transcriptome-wide association study (TWAS); BMI;
   Obesity; Insulin resistance; Type 2 diabetes; Oxidative stress; Insulin
   signaling
ID OXIDATIVE STRESS; DIABETES-MELLITUS; GENE-EXPRESSION; RISK-FACTORS;
   OBESITY; HEALTH; KORA; PREVALENCE; BIOGENESIS; DISEASE
AB Background: Obesity, defined as pathologically increased body mass index (BMI), is strongly related to an increased risk for numerous common cardiovascular and metabolic diseases. It is particularly associated with insulin resistance, hyperglycemia, and systemic oxidative stress and represents the most important risk factor for type 2 diabetes (T2D). However, the pathophysiological mechanisms underlying these associations are still not completely understood. Therefore, in order to identify potentially disease-relevant BMI-associated gene expression signatures, a transcriptome-wide association study (TWAS) on BMI was performed.
   Methods: Whole-blood mRNA levels determined by array-based transcriptional profiling were correlated with BMI in two large independent population-based cohort studies (KORA F4 and SHIP-TREND) comprising a total of 1977 individuals.
   Results: Extensive alterations of the whole-blood transcriptome were associated with BMI: More than 3500 transcripts exhibited significant positive or negative BMI-correlation. Three major whole-blood gene expression signatures associated with increased BMI were identified. The three signatures suggested: i) a ratio shift from mature erythrocytes towards reticulocytes, ii) decreased expression of several genes essentially involved in the transmission and amplification of the insulin signal, and iii) reduced expression of several key genes involved in the defence against reactive oxygen species (ROS).
   Conclusions: Whereas the first signature confirms published results, the other two provide possible mechanistic explanations for well-known epidemiological findings under conditions of increased BMI, namely attenuated insulin signaling and increased oxidative stress. The putatively causative BMI-dependent down-regulation of the expression of numerous genes on the mRNA level represents a novel finding. BMI-associated negative transcriptional regulation of insulin signaling and oxidative stress management provide new insights into the pathogenesis of metabolic syndrome and T2D.
C1 [Homuth, Georg; Schurmann, Claudia; Maeder, Ulrike; Steil, Leif; Teumer, Alexander; Voelker, Uwe] Univ Med, Interfac Inst Genet & Funct Genom, Greifswald, Germany.
   [Homuth, Georg; Schurmann, Claudia; Maeder, Ulrike; Steil, Leif; Teumer, Alexander; Voelker, Uwe] Ernst Moritz Arndt Univ Greifswald, Greifswald, Germany.
   [Wahl, Simone; Gieger, Christian; Grallert, Harald; Illig, Thomas; Marzi, Carola S.; Peters, Annette] Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Res Unit Mol Epidemiol, Neuherberg, Germany.
   [Wahl, Simone; Englbrecht, Christian; Grallert, Harald; Marzi, Carola S.] German Ctr Diabet Res DZD, Neuherberg, Germany.
   [Wahl, Simone; Gieger, Christian; Peters, Annette] Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Epidemiol 2, Neuherberg, Germany.
   [Mueller, Christian; Blankenberg, Stefan; Zeller, Tanja] Univ Herzzentrum Hamburg, Klin Allgemeine & Intervent Kardiol, Hamburg, Germany.
   [Mueller, Christian; Blankenberg, Stefan; Kruppa, Jochen; Schillert, Arne; Zeller, Tanja] DZHK German Ctr Cardiovasc Res, Partner Site Hamburg Kiel Lubeck, Hamburg, Germany.
   [Schurmann, Claudia; Doerr, Marcus; Felix, Stephan B.; Nauck, Matthias; Voelzke, Henry; Wallaschofski, Henri; Voelker, Uwe] DZHK German Ctr Cardiovasc Res, Partner Site Greifswald, Greifswald, Germany.
   [Carstensen, Maren; Herder, Christian; Roden, Michael] Univ Dusseldorf, Inst Clin Diabetol, German Diabet Ctr, Leibniz Ctr Diabet Res, Dusseldorf, Germany.
   [Carstensen, Maren; Herder, Christian; Roden, Michael] German Ctr Diabet Res DZD eV, Partner Site Dusseldorf, Dusseldorf, Germany.
   [Doerr, Marcus; Felix, Stephan B.] Univ Med Greifswald, Dept Internal Med B, Greifswald, Germany.
   [Endlich, Karlhans] Univ Med Greifswald, Inst Anat & Cell Biol, Greifswald, Germany.
   [Illig, Thomas] Hannover Med Sch, Hannover Unified Biobank, Hannover, Germany.
   [Illig, Thomas] Hannover Med Sch, Inst Human Genet, Hannover, Germany.
   [Kruppa, Jochen; Schillert, Arne; Ziegler, Andreas] Med Univ Lubeck, Inst Med Biometrie & Stat, Univ Klinikum Schleswig Holstein, D-23538 Lubeck, Germany.
   [Mayerle, Julia] Univ Med Greifswald, Dept Internal Med A, Greifswald, Germany.
   [Meitinger, Thomas; Peters, Annette; Schramm, Katharina; Prokisch, Holger] Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Human Genet, Neuherberg, Germany.
   [Meitinger, Thomas; Prokisch, Holger] DZHK German Ctr Cardiovasc Res, Partner Site Munich, Munich, Germany.
   [Meitinger, Thomas; Peters, Annette; Prokisch, Holger] Tech Univ Munich, Inst Humangenet, D-80290 Munich, Germany.
   [Meitinger, Thomas] Munich Heart Alliance, Munich, Germany.
   [Metspalu, Andres; Reinmaa, Eva] Univ Tartu, Estonian Genome Ctr, EE-50090 Tartu, Estonia.
   [Nauck, Matthias; Wallaschofski, Henri] Univ Med Greifswald, Inst Clin Chem & Lab Med, Greifswald, Germany.
   [Rathmann, Wolfgang] Univ Dusseldorf, Inst Biometr & Epidemiol, German Diabet Ctr, Leibniz Ctr Diabet Res, Dusseldorf, Germany.
   [Reinmaa, Eva] Univ Tartu, Inst Mol & Cell Biol, EE-50090 Tartu, Estonia.
   [Rettig, Rainer] Univ Med Greifswald, Inst Physiol, Karlsburg, Germany.
   [Roden, Michael] Univ Hosp Dusseldorf, Div Endocrinol & Diabetol, Dusseldorf, Germany.
   [Strauch, Konstantin] Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Genet Epidemiol, Neuherberg, Germany.
   [Strauch, Konstantin] Univ Munich, Chair Genet Epidemiol, Inst Med Informat Biometry & Epidemiol, Munich, Germany.
   [Voelzke, Henry] Univ Med Greifswald, Inst Community Med, Greifswald, Germany.
   [Wild, Philipp S.] Johannes Gutenberg Univ Mainz, Univ Med Ctr, Dept Med 2, Prevent Cardiol & Prevent Med, D-55122 Mainz, Germany.
   [Wild, Philipp S.] Johannes Gutenberg Univ Mainz, Ctr Thrombosis & Hemostasis, Univ Med Ctr, D-55122 Mainz, Germany.
   [Wild, Philipp S.] DZHK German Ctr Cardiovasc Res, Partner Site Rhine Main, Mainz, Germany.
   [Ziegler, Andreas] Med Univ Lubeck, Zentrum Klin Studien, D-23538 Lubeck, Germany.
   [Ziegler, Andreas] Univ KwaZulu Natal, Sch Stat Math & Comp Sci, Pietermaritzburg, South Africa.
C3 Universitat Greifswald; Helmholtz Association; Helmholtz-Center Munich -
   German Research Center for Environmental Health; German Center for
   Diabetes Research (DZD); Helmholtz Association; Helmholtz-Center Munich
   - German Research Center for Environmental Health; University of
   Hamburg; University Medical Center Hamburg-Eppendorf; German Centre for
   Cardiovascular Research; German Centre for Cardiovascular Research;
   Leibniz Association; Deutsches Diabetes-Zentrum (DDZ); Heinrich Heine
   University Dusseldorf; German Center for Diabetes Research (DZD);
   Universitat Greifswald; Greifswald Medical School; Universitat
   Greifswald; Greifswald Medical School; Hannover Medical School; Hannover
   Medical School; University of Kiel; Schleswig Holstein University
   Hospital; University of Lubeck; Universitat Greifswald; Greifswald
   Medical School; Helmholtz Association; Helmholtz-Center Munich - German
   Research Center for Environmental Health; German Centre for
   Cardiovascular Research; Technical University of Munich; Munich Heart
   Alliance; University of Tartu; Universitat Greifswald; Greifswald
   Medical School; Leibniz Association; Deutsches Diabetes-Zentrum (DDZ);
   Heinrich Heine University Dusseldorf; University of Tartu; Universitat
   Greifswald; Greifswald Medical School; Heinrich Heine University
   Dusseldorf; Heinrich Heine University Dusseldorf Hospital; Helmholtz
   Association; Helmholtz-Center Munich - German Research Center for
   Environmental Health; University of Munich; Universitat Greifswald;
   Greifswald Medical School; Johannes Gutenberg University of Mainz;
   Johannes Gutenberg University of Mainz; German Centre for Cardiovascular
   Research; University of Lubeck; University of Kwazulu Natal
RP Homuth, G (corresponding author), Univ Med, Interfac Inst Genet & Funct Genom, Greifswald, Germany.
EM georg.homuth@uni-greifswald.de
RI Ziegler, Andreas/MSX-0146-2025; Blankenberg, Stefan/JEZ-7394-2023;
   Schurmann, Claudia/L-1204-2016; Qasrawi, Radwan/AAA-6245-2019; Endlich,
   Karlhans/G-5485-2013; Prokisch, Holger/N-8964-2013; Meitinger,
   Thomas/O-1318-2015; Mueller, Christoph/F-2233-2014; Roden,
   Michael/AAD-3843-2019; Wild, Philipp/M-2106-2019; Dörr,
   Marcus/F-1919-2010; Grallert, Harald/B-3424-2013; Mayerle,
   Julia/W-7907-2019; Gieger, Christian/A-3083-2013; Peters,
   Annette/A-6117-2011; Teumer, Alexander/S-7438-2019; Steil,
   Leif/F-1246-2010; Ziegler, Andreas/G-4246-2012
OI Peters, Annette/0000-0001-6645-0985; Zeller, Tanja/0000-0003-3379-2641;
   Gieger, Christian/0000-0001-6986-9554; Dorr, Marcus/0000-0001-7471-475X;
   Endlich, Karlhans/0000-0001-6052-6061; Kruppa,
   Jochen/0000-0001-8376-8864; Roden, Michael/0000-0001-8200-6382; Teumer,
   Alexander/0000-0002-8309-094X; Steil, Leif/0000-0002-0733-8421;
   Prokisch, Holger/0000-0003-2379-6286; Ziegler,
   Andreas/0000-0002-8386-5397; Meitinger, Thomas/0000-0002-8838-8403;
   Wild, Philipp/0000-0003-4413-9752; Mayerle, Julia/0000-0002-3666-6459;
   Schurmann, Claudia/0000-0003-4158-9192; Muller,
   Christian/0000-0002-9449-6865; Volker, Uwe/0000-0002-5689-3448
FU BMBF (German Ministry of Education and Research); DZHK (Deutsches
   Zentrum fur Herz-Kreislauf-Forschung - German Centre for Cardiovascular
   Research); BMBF [01ZZ9603, 01ZZ0103, 01ZZ0403, 03IS2061A, 03ZIK012];
   Ministry of Cultural Affairs; Social Ministry of the Federal State of
   Mecklenburg-West Pomerania; network 'Greifswald Approach to
   Individualized Medicine (GANI_MED); BMBF Competence Network Obesity;
   Ministry of Science and Research of the State of North Rhine-Westphalia
   (MIWF NRW); German Federal Ministry of Health (BMG); German Research
   Foundation (DFG) [RA 459/2-1]; DZHK (Deutsches Zentrum fur
   Herz-Kreislauf-Forschung-German Centre for Cardiovascular Research);
   BMBF-funded Systems Biology of Metabotypes [0315494A]; BMBF (National
   Genome Research Network NGFNplus) [01GS0834, 01GS0823]; Leibniz
   Association (WGL Pakt fur Forschung und Innovation)
FX SHIP-TREND: SHIP is supported by the BMBF (German Ministry of Education
   and Research) and by the DZHK (Deutsches Zentrum fur
   Herz-Kreislauf-Forschung - German Centre for Cardiovascular Research).
   SHIP is part of the Community Medicine Research net of the University of
   Greifswald, Germany, which is funded by BMBF (grants no. 01ZZ9603,
   01ZZ0103, and 01ZZ0403), the Ministry of Cultural Affairs as well as the
   Social Ministry of the Federal State of Mecklenburg-West Pomerania, and
   the network 'Greifswald Approach to Individualized Medicine (GANI_MED)'
   funded by the BMBF (grant 03IS2061A). Generation of genome-wide data has
   been supported by the BMBF (grant no. 03ZIK012) and phenotypic analysis
   was supported by the BMBF Competence Network Obesity. The body map data
   was kindly provided by the Gene Expression Applications research group
   at Illumina. KORA F4: The KORA authors acknowledge the contributions of
   Peter Lichtner, Gertrud Eckstein, Guido Fischer, Norman Klopp, Nicole
   Spada, and all members of the Helmholtz Zentrum Munchen genotyping staff
   for generating the SNP data and Katja Junghans and Anne Loschner
   (Helmholtz Zentrum Munchen) for generating gene expression data from
   both KORA and SHIP-TREND samples. The KORA study was initiated and
   financed by the Helmholtz Zentrum Munchen - German Research Center for
   Environmental Health, which is funded by the German Federal Ministry of
   Education and Research (BMBF) and by the State of Bavaria. Furthermore,
   KORA research was supported within the Munich Center of Health Sciences
   (MC-Health), Ludwig-Maximilians-Universitat, as part of LMUinnovativ. We
   thank the field staff in Augsburg who was involved in the studies. This
   work was supported by the Ministry of Science and Research of the State
   of North Rhine-Westphalia (MIWF NRW) and the German Federal Ministry of
   Health (BMG). The Diabetes Cohort Study was funded by a German Research
   Foundation project grant to WR (DFG; RA 459/2-1). This study was
   supported in part by a grant from the BMBF to the German Center for
   Diabetes Research (DZD e. V.), by the DZHK (Deutsches Zentrum fur
   Herz-Kreislauf-Forschung-German Centre for Cardiovascular Research) and
   by the BMBF-funded Systems Biology of Metabotypes grant SysMBo#
   0315494A). Additional support was given by the BMBF (National Genome
   Research Network NGFNplus 01GS0834 and 01GS0823) and the Leibniz
   Association (WGL Pakt fur Forschung und Innovation). We thank Gabi
   Gornitzka and Astrid Hoffmann (German Diabetes Center) for excellent
   technical assistance. We thank all study participants, volunteers and
   study personnel that made this work possible.
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NR 28
TC 25
Z9 27
U1 0
U2 18
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1755-8794
J9 BMC MED GENOMICS
JI BMC Med. Genomics
PD OCT 15
PY 2015
VL 8
AR 65
DI 10.1186/s12920-015-0141-x
PG 13
WC Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Genetics & Heredity
GA CT5RL
UT WOS:000362868300002
PM 26470795
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Ohnuma, T
   Nishimon, S
   Takeda, M
   Sannohe, T
   Katsuta, N
   Arai, H
AF Ohnuma, Tohru
   Nishimon, Shohei
   Takeda, Mayu
   Sannohe, Takahiro
   Katsuta, Narimasa
   Arai, Heii
TI Carbonyl Stress and Microinflammation-Related Molecules as Potential
   Biomarkers in Schizophrenia
SO FRONTIERS IN PSYCHIATRY
LA English
DT Review
DE AGEs; biomarkers; carbonyl stress; glyceraldehyde-derived AGEs;
   microinflammation; pentosidine; schizophrenia; soluble tumor necrosis
   factor receptor 1
ID GLYCATION END-PRODUCTS; ALZHEIMERS-DISEASE; BIPOLAR DISORDER; OXIDATIVE
   STRESS; 2ND-GENERATION ANTIPSYCHOTICS; INFLAMMATORY BIOMARKERS;
   PSYCHIATRIC-PATIENTS; NEUROTROPHIC FACTOR; METABOLIC SYNDROME;
   ADIPONECTIN LEVELS
AB This literature review primarily aims to summarize our research, comprising both cross-sectional and longitudinal studies, and discuss the possibility of using microinflammation-related biomarkers as peripheral biomarkers in the diagnosis and monitoring of patients with schizophrenia. To date, several studies have been conducted on peripheral biomarkers to recognize the potential markers for the diagnosis of schizophrenia and to determine the state and effects of therapy in patients with schizophrenia. Research has established a correlation between carbonyl stress, an environmental factor, and the pathophysiology of neuropsychiatric diseases, including schizophrenia. In addition, studies on biomarkers related to these stresses have achieved results that are either replicable or exhibit consistent increases or decreases in patients with schizophrenia. For instance, pentosidine, an advanced glycation end product (AGE), is considerably elevated in patients with schizophrenia; however, low levels of vitamin B6 [ a detoxifier of reactive carbonyl compounds (RCOs)] have also been reported in some patients with schizophrenia. Another study on peripheral markers of carbonyl stress in patients with schizophrenia revealed a correlation of higher levels of glyceraldehyde-derived AGEs with higher neurotoxicity and lower levels of soluble receptors capable of diminishing the effects of AGEs. Furthermore, studies on evoked microinflammation-related biomarkers (e. g., soluble tumor necrosis factor receptor 1) have reported relatively consistent results, suggesting the involvement of microinflammation in the pathophysiology of schizophrenia. We believe that our cross-sectional and longitudinal studies as well as various previous inflammation marker studies that could be interpreted from several perspectives, such as mild localized encephalitis and microvascular disturbance, highlighted the importance of early intervention as prevention and distinguished the possible exclusion of inflammations in schizophrenia.
C1 [Ohnuma, Tohru; Nishimon, Shohei; Takeda, Mayu; Sannohe, Takahiro; Katsuta, Narimasa; Arai, Heii] Juntendo Univ, Fac Med, Dept Psychiat, JUSP, Tokyo, Japan.
C3 Juntendo University
RP Ohnuma, T (corresponding author), Juntendo Univ, Fac Med, Dept Psychiat, JUSP, Tokyo, Japan.
EM otoru@juntendo.ac.jp
RI Ohnuma, Tohru/AAN-2363-2020; 成昌, 勝田/HSF-3857-2023
OI Nishimon, Shohei/0000-0002-0666-3425; Ohnuma, Tohru/0000-0003-1522-3832
FU Juntendo Institute of Mental Health [201607]
FX This work was supported by the Juntendo Institute of Mental Health from
   2016 to 2017 (201607).
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NR 61
TC 21
Z9 21
U1 0
U2 4
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA PO BOX 110, EPFL INNOVATION PARK, BUILDING I, LAUSANNE, 1015,
   SWITZERLAND
SN 1664-0640
J9 FRONT PSYCHIATRY
JI Front. Psychiatry
PD MAR 13
PY 2018
VL 9
AR 82
DI 10.3389/fpsyt.2018.00082
PG 8
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA FZ0PA
UT WOS:000427271800001
PM 29593588
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Bahari, H
   Rafiei, H
   Goudarzi, K
   Omidian, K
   Asbaghi, O
   Kolbadi, KSH
   Naderian, M
   Hosseini, A
AF Bahari, Hossein
   Rafiei, Hossein
   Goudarzi, Kian
   Omidian, Kosar
   Asbaghi, Omid
   Kolbadi, Kosar Sadat Hosseini
   Naderian, Moslem
   Hosseini, Ali
TI The effects of pomegranate consumption on inflammatory and oxidative
   stress biomarkers in adults: a systematic review and meta-analysis
SO INFLAMMOPHARMACOLOGY
LA English
DT Review
DE Pomegranate; Inflammation; Oxidative stress; Systematic review;
   Meta-analysis
ID CARDIOVASCULAR RISK-FACTORS; EXTRACT SUPPLEMENTATION; JUICE CONSUMPTION;
   HEMODIALYSIS-PATIENTS; ENDOTHELIAL FUNCTION; METABOLIC SYNDROME; PEEL
   EXTRACT; DOUBLE-BLIND; OBESE WOMEN; ANTHOCYANINS
AB BackgroundSeveral studies have shown the effects of pomegranate on oxidative stress and inflammation biomarkers, while some studies showed no effects of pomegranate on these biomarkers. Therefore, we aimed to evaluate the effects of pomegranate consumption on C-reactive protein (CRP), interlukin-6 (IL-6), tumor necrosis factor & alpha; (TNF-& alpha;), total antioxidant capacity (TAC), and malondialdehyde (MDA) in adults.MethodsA systematic literature search was performed using databases, including PubMed, Web of Science, and Scopus, up to May 2023 to identify eligible randomized controlled trials (RCTs). Heterogeneity tests of the included trials were performed using the I-2 statistic. Random effects models were assessed based on the heterogeneity tests, and pooled data were determined as the weighted mean difference with a 95% confidence interval.ResultsOf 3811 records, 33 eligible RCTs were included in the current study. Our meta-analysis of the pooled findings showed that pomegranate consumption significantly reduced CRP (WMD: -0.50 mg/l; 95% CI -0.79 to -0.20; p = 0.001), IL-6 (WMD: -1.24 ng/L 95% CI -1.95 to -0.54; p = 0.001), TNF-& alpha; (WMD: -1.96 pg/ml 95%CI -2.75 to -1.18; p < 0.001), and MDA (WMD: -0.34 nmol/ml 95%CI -0.42 to -0.25; p < 0.001). Pooled analysis of 13 trials revealed that pomegranate consumption led to a significant increase in TAC (WMD: 0.26 mmol/L 95%CI 0.03 to 0.49; p = 0.025).ConclusionOverall, the results demonstrated that pomegranate consumption has beneficial effects on oxidative stress and inflammatory biomarkers in adults. Therefore, pomegranate can be consumed as an effective dietary approach to attenuate oxidative stress and inflammation in patients with cardiovascular diseases.PROSPERO registration codeCRD42023406684
C1 [Bahari, Hossein] Mashhad Univ Med Sci, Fac Med, Dept Nutr, Mashhad, Iran.
   [Rafiei, Hossein; Omidian, Kosar] Univ Saskatchewan, Coll Pharm & Nutr, Saskatoon, SK, Canada.
   [Goudarzi, Kian] Shahid Beheshti Univ Med Sci, Fac Med, Tehran, Iran.
   [Asbaghi, Omid] Shahid Beheshti Univ Med Sci, Canc Res Ctr, Tehran, Iran.
   [Asbaghi, Omid] Shahid Beheshti Univ Med Sci, Student Res Comm, Tehran, Iran.
   [Kolbadi, Kosar Sadat Hosseini] Iran Univ Med Sci, Fac Med, Tehran, Iran.
   [Naderian, Moslem; Hosseini, Ali] Shiraz Univ Med Sci, Sch Pharm, Dept Pharmacognosy, Shiraz, Iran.
   [Naderian, Moslem] Yasuj Univ Med Sci, Med Plants Res Ctr, Yasuj, Iran.
C3 Mashhad University of Medical Sciences; University of Saskatchewan;
   Shahid Beheshti University Medical Sciences; Shahid Beheshti University
   Medical Sciences; Shahid Beheshti University Medical Sciences; Iran
   University of Medical Sciences; Shiraz University of Medical Science;
   Yasouj University
RP Naderian, M; Hosseini, A (corresponding author), Shiraz Univ Med Sci, Sch Pharm, Dept Pharmacognosy, Shiraz, Iran.; Naderian, M (corresponding author), Yasuj Univ Med Sci, Med Plants Res Ctr, Yasuj, Iran.
EM baharihossein3@gmail.com; hossein.rafiei@usask.ca;
   kiangoudarzi2@gmail.com; kosar.omidian@gmail.com;
   omid.asbaghi@gmail.com; m_naderian_66@yahoo.com; alihosseini13@yahoo.com
RI bahari, hossein/AEP-7036-2022; Hosseini, Ali/HJI-4726-2023; Rafiei,
   Hossein/W-4825-2017
OI Bahari, Hossein/0000-0002-3787-2713; Rafiei, Hossein/0000-0002-4843-9261
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NR 85
TC 16
Z9 16
U1 1
U2 3
PU SPRINGER BASEL AG
PI BASEL
PA PICASSOPLATZ 4, BASEL, 4052, SWITZERLAND
SN 0925-4692
EI 1568-5608
J9 INFLAMMOPHARMACOLOGY
JI Inflammopharmacology
PD OCT
PY 2023
VL 31
IS 5
BP 2283
EP 2301
DI 10.1007/s10787-023-01294-x
EA JUL 2023
PG 19
WC Immunology; Pharmacology & Pharmacy; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Pharmacology & Pharmacy; Toxicology
GA S8JK9
UT WOS:001039818700001
PM 37507609
DA 2025-06-11
ER

PT J
AU Dias, DD
   Moraes-Silva, IC
   Bernardes, N
   Brito-Monzani, JD
   Stoyell-Conti, FF
   Machi, JF
   Llesuy, S
   Irigoyen, MC
   De Angelis, K
AF Dias, Danielle da Silva
   Moraes-Silva, Ivana C.
   Bernardes, Nathalia
   Brito-Monzani, Janaina de Oliveira
   Stoyell-Conti, Filipe Fernandes
   Machi, Jacqueline Freire
   Llesuy, Susana
   Irigoyen, Maria-Claudia
   De Angelis, Katia
TI Exercise training initiated at old stage of lifespan attenuates
   aging-and ovariectomy-induced cardiac and renal oxidative stress: Role
   of baroreflex
SO EXPERIMENTAL GERONTOLOGY
LA English
DT Article
DE Aging; Menopause; Exercise training; Hemodynamics; Oxidative stress;
   Autonomic nervous system
ID DECREASES BLOOD-PRESSURE; NITRIC-OXIDE; AUTONOMIC DYSFUNCTION;
   EXPERIMENTAL-MODEL; METABOLIC SYNDROME; SENSITIVITY; RESISTANCE;
   MENOPAUSE; BENEFITS; RATS
AB Background: The association of aging and menopause is a potent risk factor for cardiometabolic disease. We studied the impact of aerobic exercise training (ET) initiated in the old stage of lifespan in hemodynamics, metabolic, autonomic and oxidative stress.
   Methods: Aged (18 months old) female Wistar rats were divided into: ovariectomized and untrained (AG-OVX), and ovariectomized and trained (AG-OVXt, ET for 8 weeks). Intact aged (AG) and young female rats (3 months old; Y) were also studied. Blood pressure and metabolic parameters were measured. Baroreflex sensitivity (BRS) was studied by bradycardic (BR) and tachycardic (TR) responses to vasoactive drugs. Cardiac and renal lipid peroxidation (LPO), catalase (CAT), superoxide dismutase (SOD) and gluthatione peroxidase (GPx), and gluthatione redox balance (GSH/GSSG) were analyzed.
   Results: AG-OVXt group increased aerobic performance in 35%, decreased adipose tissue and triglycerides in 36% and 27%, respectively, and improved insulin tolerance in 50% in comparison to AG-OVX. AG-OVX presented hypertensive levels of blood pressure (systolic: 155 +/- 5, diastolic: 111 +/- 3 mmHg). In contrast, AG-OVXt presented blood pressure values similar to Y rats (systolic: 129 +/- 3, diastolic: 112 +/- 3 mmHg). TR and BR were reduced by 70% and 46%, respectively, in AG-OVX vs. Y. Once more, AG-OVXt presented similar results to Y. ET decreased LPO in the heart and kidney. In the latter, renal CAT and SOD were corrected by ET, while cardiac redox balance was partially recovered. Improved BRS was correlated with improved oxidative stress markers.
   Conclusions: Even when initiated after aging and ovariectomy deleterious effects, ET is able to normalize BRS and highly improve cardiac and renal oxidative stress.
C1 [Dias, Danielle da Silva; Bernardes, Nathalia; Brito-Monzani, Janaina de Oliveira; Stoyell-Conti, Filipe Fernandes; De Angelis, Katia] Univ Nove Julho UNINOVE, Lab Translat Physiol, Sao Paulo, Brazil.
   [Dias, Danielle da Silva; De Angelis, Katia] Univ Fed Sao Paulo, Dept Physiol, Sao Paulo, Brazil.
   [Moraes-Silva, Ivana C.; Machi, Jacqueline Freire; Irigoyen, Maria-Claudia] Univ Sao Paulo, Heart Inst InCor, Hypertens Unit, Med Sch, Sao Paulo, Brazil.
   [Llesuy, Susana] Univ Buenos Aires, Dept Gen & Inorgan Chem, Buenos Aires, DF, Argentina.
   [Brito-Monzani, Janaina de Oliveira] Univ Fed Maranhao, Sao Luis, Brazil.
   [Stoyell-Conti, Filipe Fernandes] Nova Southeastern Univ, Coll Pharm, Ft Lauderdale, FL 33314 USA.
   [Machi, Jacqueline Freire] Univ Miami, Dept Mol & Cellular Pharmacol, Coral Gables, FL 33124 USA.
C3 Universidade Nove de Julho; Universidade Federal de Sao Paulo (UNIFESP);
   Universidade de Sao Paulo; University of Buenos Aires; Universidade
   Federal do Maranhao; Nova Southeastern University; University of Miami
RP De Angelis, K (corresponding author), Fed Univ Sao Paulo UNIFESP, Dept Physiol, Rua Botucatu,862,EdifIcio Ciencias Biomed,5 Andar, BR-04023062 Sao Paulo, SP, Brazil.
EM katia.angelis@unifesp.br
RI da Silva Dias, Danielle/AAN-7618-2020; Moraes-Silva, Ivana/K-2557-2019;
   Bernardes, Nathalia/L-7460-2015; DE ANGELIS, KATIA/I-6098-2016;
   Irigoyen, maria Claudia/N-6880-2014
OI DE ANGELIS, KATIA/0000-0002-3640-9049; Irigoyen, maria
   Claudia/0000-0003-2097-3662
FU Conselho Nacional de Desenvolvimento Cientifico e
   Tecnologico(CNPq-Brazil) [427892/2018-0, 457200/2014-6, 309292/2014-0];
   FAPESP [2018/19006-2, 2018/17183-4, 2015/11223-6]; CAPES
   [88881.062178/2014-01]; CAPES-PROSUP; CAPES-DFAIT; CNPq Fellowship
   (CNPq-BPQ)
FX This study was supported by Conselho Nacional de Desenvolvimento
   Cientifico e Tecnologico(CNPq-Brazil) (427892/2018-0; 457200/2014-6;
   309292/2014-0) and FAPESP (2018/19006-2; 2018/17183-4; 2015/11223-6);
   CAPES (88881.062178/2014-01; CAPES-PROSUP; CAPES-DFAIT). Katia De
   Angelis and Maria-Claudia Irigoyen are recipients of CNPq Fellowship
   (CNPq-BPQ).
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NR 63
TC 10
Z9 10
U1 0
U2 6
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0531-5565
EI 1873-6815
J9 EXP GERONTOL
JI Exp. Gerontol.
PD SEP
PY 2019
VL 124
AR 110635
DI 10.1016/j.exger.2019.110635
PG 7
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA IK4XE
UT WOS:000476589500012
PM 31195102
DA 2025-06-11
ER

PT J
AU Kawarazaki, H
   Ando, K
   Shibata, S
   Muraoka, K
   Fujita, M
   Kawarasaki, C
   Fujita, T
AF Kawarazaki, Hiroo
   Ando, Katsuyuki
   Shibata, Shigeru
   Muraoka, Kazuhiko
   Fujita, Megumi
   Kawarasaki, Chiaki
   Fujita, Toshiro
TI Mineralocorticoid receptor-Rac1 activation and oxidative stress play
   major roles in salt-induced hypertension and kidney injury in
   prepubertal rats
SO JOURNAL OF HYPERTENSION
LA English
DT Article
DE aldosterone; hypertension; kidney injury; mineralocorticoid receptor;
   oxidative stress; prepuberty; Rac1; salt sensitivity
ID BLOOD-PRESSURE; ESTROGEN-RECEPTOR; SENSITIVE RATS; ANGIOTENSIN-II; RENAL
   INJURY; METABOLIC SYNDROME; ENDOTHELIAL-CELLS; PROTEIN-KINASE;
   SHEAR-STRESS; RAC1 GTPASE
AB Objectives: To elucidate the roles that renal mineralocorticoid receptor Rac1 interactions and oxidative stress play in salt-induced hypertension and renal injury in prepubertal rats.
   Methods: Three-week-old male Sprague Dawley rats were uninephrectomized (UNx) and fed a high-salt (8% NaCl) diet for 4 weeks. Five were left untreated, whereas the remaining rats were administered an mineralocorticoid receptor blocker (n = 5), a Rac1 inhibitor (n = 5), a Rho-kinase inhibitor (n = 5), or the superoxide dismutase mimetic tempol (n = 5). A control group of young UNx rats (n = 5) was fed a normal-salt (0.5% NaCl) diet. The rats were sacrificed after a 4-week experimental period. Blood pressure, urinary protein, histological morphology, and renal serum-regulated and glucocorticoid-regulated kinase (Sgk) 1 and Rac1 expression were evaluated. The effect of adrenalectomy with dexamethasone supplementation in young salt-loaded UNx rats (n = 5) was also evaluated.
   Results: Excessive salt intake induced hypertension and proteinuria in the young UNx rats, whose kidneys showed marked histological injury, Sgk1 overexpression and Rac1 activation. Both mineralocorticoid receptor blockade and Rac1 inhibition markedly prevented these abnormalities associated with a reduction in renal Rac1 expression. Adrenalectomy, but not Rho-kinase inhibition, also prevented salt-induced renal injury. Interestingly, tempol inhibited renal Rac1 activation and renal injury.
   Conclusions: These findings suggest that Rac1-related mineralocorticoid receptor activation contributed to salt-induced hypertension and kidney injury in young UNx rats. Furthermore, as adrenalectomy abrogated salt-induced proteinuria, Rac1 may be an enhancer of aldosterone-induced mineralocorticoid receptor activation. Oxidative stress may also modify the interaction between Rac1 and mineralocorticoid receptor.
C1 [Kawarazaki, Hiroo] St Marianna Univ, Sch Med, Dept Hypertens & Nephrol, Miyamae Ku, Kawasaki, Kanagawa 2168511, Japan.
   [Ando, Katsuyuki; Shibata, Shigeru; Muraoka, Kazuhiko; Fujita, Megumi; Kawarasaki, Chiaki; Fujita, Toshiro] Univ Tokyo, Dept Nephrol & Endocrinol, Tokyo, Japan.
C3 Saint Marianna University; University of Tokyo
RP Kawarazaki, H (corresponding author), St Marianna Univ, Sch Med, Dept Hypertens & Nephrol, Miyamae Ku, 2-16-1 Sugao, Kawasaki, Kanagawa 2168511, Japan.
EM hirookawarazaki@yahoo.co.jp
OI Shibata, Shigeru/0000-0002-6868-0626
FU Pfizer Japan, Inc.; Daiichi Sankyo Company, Ltd.; Grants-in-Aid for
   Scientific Research [22590908, 24591226, 21229012] Funding Source: KAKEN
FX This work was supported by grants from Pfizer Japan, Inc. and the
   Daiichi Sankyo Company, Ltd.
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NR 34
TC 30
Z9 30
U1 0
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0263-6352
J9 J HYPERTENS
JI J. Hypertens.
PD OCT
PY 2012
VL 30
IS 10
BP 1977
EP 1985
DI 10.1097/HJH.0b013e3283576904
PG 9
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 006YA
UT WOS:000308854500018
PM 22914542
DA 2025-06-11
ER

PT J
AU Nan, YM
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   Fu, Na
   Liang, Bao-Li
   Wang, Rong-Qi
   Li, Liang-Xiao
   Zhao, Su-Xian
   Zhao, Jing-Min
   Yu, Jun
TI Antioxidants vitamin E and 1-aminobenzotriazole prevent experimental
   non-alcoholic steatohepatitis in mice
SO SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
LA English
DT Article
DE Antioxidant; apoptosis; non-alcoholic steatohepatitis; oxidative stress
ID FATTY LIVER-DISEASE; NF-KAPPA-B; OXIDATIVE STRESS; MOLECULAR-MECHANISMS;
   HEPATOCYTE APOPTOSIS; INSULIN-RESISTANCE; METABOLIC SYNDROME; FIBROSIS;
   ADIPONECTIN; EXPRESSION
AB Objective. Hepatic oxidative stress plays a key role in the development of non-alcoholic steatohepatitis (NASH). However, the protective effects of antioxidants on NASH are largely unknown. The aim of this study was to elucidate the effect and mechanism of antioxidants on NASH in mice. Material and methods. C57BL6/J mice were fed a methionine-choline-deficient (MCD) diet for 10 days or 3 weeks to induce steatohepatitis. Antioxidants (vitamin E, ABT, or vitamin E plus ABT) were supplemented in mice fed a MCD diet, respectively. The effect of antioxidants on oxidative stress and apoptosis was assessed, and activation of adiponectin and expressions of inflammatory factors, apoptosis-related genes, and fibrosis-related genes were assayed. Results. MCD feeding in mice showed increasing serum alanine aminotransferase (ALAT) and aspartate aminotransferase (ASAT) levels, and progressive hepatic injury including hepatic steatosis and inflammatory infiltration. Administration of antioxidants vitamin E and/or ABT significantly lowered serum ALAT and ASAT levels (p<0.001) and ameliorated hepatic steatosis and necroinflammation. These effects were associated with repressed hepatic lipid peroxides through reducing hepatic MDA content and enhancing hepatic superoxide dismutase (SOD) activity; down-regulated inflammatory factor COX-2, lowered activity of NF-kappa B, up-regulated anti-apoptotic gene Bcl-2, and down-regulated pro-apoptotic gene Bax suppressed expression of the fibrotic genes TGF-beta 1 and MMP2. Moreover, expression of the anti-inflammatory factor adiponectin was also induced by vitamin E or ABT. A combination of vitamin E and ABT showed an additive effect on preventing liver injury. Conclusions. The present study provides morphological and molecular biological evidence for the protective role of the antioxidant vitamins E and ABT in ameliorating oxidative stress, hepatic apoptosis, and necroinflammation in experimental nutritional steatohepatitis.
C1 [Nan, Yue-Min; Wu, Wen-Juan; Fu, Na; Liang, Bao-Li; Wang, Rong-Qi; Li, Liang-Xiao; Zhao, Su-Xian] Hebei Med Univ, Hosp 3, Dept Tradit & Western Med Hepatol, Shijiazhuang, Peoples R China.
   [Zhao, Jing-Min] Beijing 302 Hosp, Dept Pathol, Beijing, Peoples R China.
   [Yu, Jun] Chinese Univ Hong Kong, Inst Digest Dis, Hong Kong, Hong Kong, Peoples R China.
   [Yu, Jun] Chinese Univ Hong Kong, Li Ka Shing Inst Hlth Sci, Hong Kong, Hong Kong, Peoples R China.
   [Yu, Jun] Hebei Med Univ, Hosp 1, Dept Gastroenterol, Shijiazhuang, Peoples R China.
C3 Hebei Medical University; Fifth Medical Center of Chinese PLA General
   Hospital; Chinese University of Hong Kong; Chinese University of Hong
   Kong; Hebei Medical University
RP Nan, YM (corresponding author), Hebei Med Univ, Hosp 3, Dept Hepatol, Shijiazhuang, Peoples R China.
EM nanyuemin@163.com
RI Wu, wenjuan/GPX-6968-2022; Jun, Yu/D-8569-2015
OI Jun, Yu/0000-0001-5008-2153
FU Hebei Natural Science Fund [C2006000842]; Research Grants Council
   Competitive Earmarked Research [478108]
FX This work was funded by the Hebei Natural Science Fund, No. C2006000842
   and by the Research Grants Council Competitive Earmarked Research, Grant
   CUHK 478108.
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NR 47
TC 81
Z9 90
U1 0
U2 8
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0036-5521
EI 1502-7708
J9 SCAND J GASTROENTERO
JI Scand. J. Gastroenterol.
PY 2009
VL 44
IS 9
BP 1121
EP 1131
DI 10.1080/00365520903114912
PG 11
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 503AW
UT WOS:000270504600014
PM 19606393
DA 2025-06-11
ER

PT J
AU Bostick, B
   Habibi, J
   DeMarco, VG
   Jia, GH
   Domeier, TL
   Lambert, MD
   Aroor, AR
   Nistala, R
   Bender, SB
   Garro, M
   Hayden, MR
   Ma, LX
   Manrique, C
   Sowers, JR
AF Bostick, Brian
   Habibi, Javad
   DeMarco, Vincent G.
   Jia, Guanghong
   Domeier, Timothy L.
   Lambert, Michelle D.
   Aroor, Annayya R.
   Nistala, Ravi
   Bender, Shawn B.
   Garro, Mona
   Hayden, Melvin R.
   Ma, Lixin
   Manrique, Camila
   Sowers, James R.
TI Mineralocorticoid receptor blockade prevents Western diet-induced
   diastolic dysfunction in female mice
SO AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
LA English
DT Article
DE mineralocorticoid antagonism; low-dose spironolactone; aldosterone;
   high-fat diet; high-fructose diet; oxidative stress; inflammation;
   cardiac hypertrophy; myocardial compliance
ID PRESERVED EJECTION FRACTION; LEFT-VENTRICULAR DYSFUNCTION;
   OBESITY-RELATED CHANGES; INSULIN-RESISTANCE; HEART-FAILURE; OXIDATIVE
   STRESS; DIABETES-MELLITUS; METABOLIC SYNDROME; BLOOD-PRESSURE;
   CARDIOVASCULAR-DISEASES
AB Overnutrition/obesity predisposes individuals, particularly women, to diastolic dysfunction (DD), an independent predictor of future cardiovascular disease. We examined whether low-dose spironolactone (Sp) prevents DD associated with consumption of a Western Diet (WD) high in fat, fructose, and sucrose. Female C57BL6J mice were fed a WD with or without Sp (1 mg.kg(-1).day(-1)). After 4 mo on the WD, mice exhibited increased body weight and visceral fat, but similar blood pressures, compared with control diet-fed mice. Sp prevented the development of WD-induced DD, as indicated by decreased isovolumic relaxation time and an improvement in myocardial performance (<Tei index) and septal annular velocity (<E' -to-A' ratio), as assessed by echocardiography, as well as decreased diastolic relaxation time/increased diastolic initial filling rate, as assessed by MRI. The relationship between passive sarcomere length of cardiac myocytes and ventricular pressure was monitored using di-8-ANEPPS staining of the t-tubule network in hearts ex vivo. Sp administration led to longer sarcomere lengths at each pressure indicative of improved ventricular compliance in WD-fed mice. Sp also prevented left ventricular hypertrophy, interstitial fibrosis, and oxidative stress. Sp prevented the WD-induced increased expression of myocardial proinflammatory M1 macrophage markers monocyte chemoattractant protein-1 and CD11c and increased the expression of the anti-inflammatory M2 macrophage marker CD206. These findings demonstrate that WD-induced DD is associated with increased oxidant stress, fibrosis, and immune dysregulation. Mineralocorticoid receptor antagonism enhanced M2 macrophage polarization and ameliorated oxidant stress and fibrosis. This work supports a novel blood pressure-independent effect of MR antagonism as a strategy to prevent diet-induced DD in women.
C1 [Bostick, Brian] Univ Missouri, Dept Med, Div Cardiovasc Med, Columbia, MO 65212 USA.
   [Habibi, Javad; DeMarco, Vincent G.; Jia, Guanghong; Aroor, Annayya R.; Garro, Mona; Hayden, Melvin R.; Manrique, Camila; Sowers, James R.] Univ Missouri, Div Endocrinol Diabet & Metab, Columbia, MO 65212 USA.
   [Nistala, Ravi] Univ Missouri, Div Nephrol, Columbia, MO 65212 USA.
   [DeMarco, Vincent G.; Domeier, Timothy L.; Lambert, Michelle D.; Ma, Lixin; Sowers, James R.] Univ Missouri, Dept Med Pharmacol & Physiol, Columbia, MO 65212 USA.
   [Sowers, James R.] Univ Missouri, Dept Radiol, Columbia, MO 65212 USA.
   [Bender, Shawn B.] Univ Missouri, Dept Biomed Sci, Columbia, MO 65212 USA.
   [Habibi, Javad; DeMarco, Vincent G.; Jia, Guanghong; Aroor, Annayya R.; Nistala, Ravi; Bender, Shawn B.; Garro, Mona; Hayden, Melvin R.; Ma, Lixin; Manrique, Camila; Sowers, James R.] Harry S Truman Mem Vet Hosp, Res Serv, Columbia, MO 65201 USA.
   [Bender, Shawn B.; Sowers, James R.] Dalton Cardiovasc Res Ctr, Columbia, MO USA.
C3 University of Missouri System; University of Missouri Columbia;
   University of Missouri System; University of Missouri Columbia;
   University of Missouri System; University of Missouri Columbia;
   University of Missouri System; University of Missouri Columbia;
   University of Missouri System; University of Missouri Columbia;
   University of Missouri System; University of Missouri Columbia; US
   Department of Veterans Affairs; Veterans Health Administration (VHA);
   Harry S. Truman Memorial Veterans' Hospital
RP Sowers, JR (corresponding author), Univ Missouri, Dept Med, Sch Med, Div Endocrinol Diabet & Metab, One Hosp Dr, Columbia, MO 65212 USA.
EM sowersj@missouri.edu
OI DeMarco, Vincent/0000-0003-2092-9995; Ma, Lixin/0000-0003-2171-1226;
   Domeier, Timothy/0000-0003-0340-6551
FU American Heart Association Postdoctoral Fellowship [13POST16250010];
   National Institutes of Health [R01-HL073101, RO1-HL107910,
   K01-AG-041208]; Department of Veterans Affairs Biomedical Laboratory
   Research and Development [CDA-2 IK2 BX002030, 0018]; American Heart
   Association (AHA) [13POST16250010] Funding Source: American Heart
   Association (AHA)
FX This work was also supported by American Heart Association Postdoctoral
   Fellowship 13POST16250010 (to B. Bostick), National Institutes of Health
   Grants R01-HL073101 and RO1-HL107910 (to J. R. Sowers) and K01-AG-041208
   (to T. L. Domeier), Department of Veterans Affairs Biomedical Laboratory
   Research and Development Grants CDA-2 IK2 BX002030 (to S. B. Bender) and
   0018 (to J. R. Sowers).
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NR 70
TC 63
Z9 72
U1 0
U2 12
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0363-6135
EI 1522-1539
J9 AM J PHYSIOL-HEART C
JI Am. J. Physiol.-Heart Circul. Physiol.
PD MAY 1
PY 2015
VL 308
IS 9
BP H1126
EP H1135
DI 10.1152/ajpheart.00898.2014
PG 10
WC Cardiac & Cardiovascular Systems; Physiology; Peripheral Vascular
   Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Physiology
GA CH3VP
UT WOS:000353959000020
PM 25747754
OA Green Published
DA 2025-06-11
ER

PT J
AU Yao, F
   Li, Z
   Ehara, T
   Yang, L
   Wang, DD
   Feng, LL
   Zhang, YM
   Wang, K
   Shi, YH
   Duan, HJ
   Zhang, LS
AF Yao, Fang
   Li, Zhen
   Ehara, Takashi
   Yang, Lin
   Wang, Dandan
   Feng, Lulu
   Zhang, Yiming
   Wang, Kun
   Shi, Yonghong
   Duan, Huijun
   Zhang, Lianshan
TI Fatty Acid-Binding Protein 4 mediates apoptosis via endoplasmic
   reticulum stress in mesangial cells of diabetic nephropathy
SO MOLECULAR AND CELLULAR ENDOCRINOLOGY
LA English
DT Article
DE Apoptosis; Diabetic nephropathy; Endoplasmic reticulum stress; Fatty
   acid-binding protein 4; Mesangial cell
ID METABOLIC SYNDROME; KIDNEY-DISEASE; IN-VIVO; ATHEROSCLEROSIS; AP2;
   PALMITATE; OLEATE; INS-1; INFLAMMATION; DYSLIPIDEMIA
AB Type 2 diabetes is characterized by hyperglycemia and deregulated lipid metabolism with increased plasma non-esterified fatty acids (NEFA). Apoptosis of glomerular cells is a hallmark in diabetic glomerulosclerosis. Fatty acid-binding protein 4 (FABP4), a carrier protein for fatty acids, has been linked to diabetes and diabetic nephropathy (DN). Here we aimed to investigate the link between FABP4 and apoptosis in diabetic glomerulosclerosis. We first evaluated the presence of FABP4 and ER stress markers as well as apoptosis-related proteins in renal biopsies of patients with DN. Then we used FABP4 inhibitor BMS309403 or siRNA to further investigate the role of FABP4 in ER stress and apoptosis induced by NEFA or high glucose in cultured human mesangial cells (HMCs).
   We found FABP4 was expressed mainly in glomerular mesangial cells of the human renal biopsies and the glomerular FABP4 was increased in renal biopsies of DN. The up-regulation of FABP4 was accompanied with increased glucose-regulated protein 78 (GRP78) and Caspase-12 as well as downregulated B-cell CLL/Iymphoma 2 (Bcl-2) in glomeruli. Along with the induction of FABP4 and apoptosis, GRP78 and its three sensors as well as C/EBP homologous protein (CHOP) and Caspase-12 were induced in HMCs treated with NEFA or high glucose and these responses were attenuated or even abrogated by treating with FABP4 inhibitor or FABP4 siRNA. Ultrastructure observation confirmed the lipotoxicity of oleic acid by showing the morphological damage in HMCs. Our data suggest that FABP4 in glomerular mesangial cells is up-regulated in DN and FABP4 mediates apoptosis via the ER stress in HMCs. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
C1 [Yao, Fang; Li, Zhen; Wang, Dandan; Feng, Lulu; Zhang, Yiming; Wang, Kun; Shi, Yonghong; Duan, Huijun; Zhang, Lianshan] Hebei Med Univ, Dept Pathol, Shijiazhuang 050017, Hebei, Peoples R China.
   [Yao, Fang; Yang, Lin; Shi, Yonghong; Duan, Huijun; Zhang, Lianshan] Key Lab Kidney Dis Hebei Prov, Shijiazhuang, Peoples R China.
   [Li, Zhen] First Hosp Changsha City, Dept Pathol, Changsha, Peoples R China.
   [Ehara, Takashi] Matsumoto Univ, Dept Hlth & Sport Sci, Grad Sch Hlth Sci, Matsumoto, Nagano, Japan.
C3 Hebei Medical University
RP Zhang, LS (corresponding author), Hebei Med Univ, Dept Pathol, 361 East Zhongshan Rd, Shijiazhuang 050017, Hebei, Peoples R China.
EM lianshanzh@163.com
RI Wang, Dandan/LBH-3416-2024
OI , Fang/0000-0002-7272-9138
FU Natural Science Foundation of Hebei Province [C2010000477]; Youth
   Foundation of Hebei Province, China [2010150]
FX This study was supported by grants from Natural Science Foundation of
   Hebei Province (No. C2010000477) and Youth Foundation of Hebei Province,
   China (No. 2010150).
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NR 45
TC 68
Z9 72
U1 0
U2 51
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0303-7207
J9 MOL CELL ENDOCRINOL
JI Mol. Cell. Endocrinol.
PD AUG 15
PY 2015
VL 411
IS C
BP 232
EP 242
DI 10.1016/j.mce.2015.05.003
PG 11
WC Cell Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Endocrinology & Metabolism
GA CL1XU
UT WOS:000356739000025
PM 25958041
DA 2025-06-11
ER

PT J
AU Lin, WY
   Chen, CS
   Wu, SB
   Lin, YP
   Levin, RM
   Wei, YH
AF Lin, Wei-Yu
   Chen, Chih-Shou
   Wu, Shi-Bei
   Lin, Yi-Pai
   Levin, Robert M.
   Wei, Yau-Huei
TI Oxidative stress biomarkers in urine and plasma of rabbits with partial
   bladder outlet obstruction
SO BJU INTERNATIONAL
LA English
DT Article
DE partial bladder outlet obstruction (PBOO); lower urinary tract symptoms
   (LUTS); 8-hydroxy-2 '-deoxyguanosine (8-OHdG); malondialdehyde (MDA);
   total antioxidant capacity (TAC)
ID VESICOVASCULAR REFLEX; LIPOIC ACID; DAMAGE; MALONDIALDEHYDE;
   DYSFUNCTION; MARKERS; INJURY
AB OBJECTIVE
   To investigate oxidative stress and oxidative damage biomarkers in urine and plasma after partial bladder outlet obstruction (PBOO) in rabbits.
   MATERIALS AND METHODS
   In all, 16 male New Zealand White rabbits were separated equally into four groups: a control group and PBOO-treated groups for 2, 4 and 8 weeks.
   The oxidative stress biomarkers assessed included urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG) and plasma malondialdehyde (MDA).
   We also measured the total antioxidant capacity (TAC) in blood plasma.
   8-OHdG, MDA and TAC were measured at both the beginning and indicated time points of the experimental design.
   RESULTS
   There was no significant difference in body weight among rabbits in the four groups.
   However, there was a significant increase in bladder weight after 2 weeks of PBOO. After 4 and 8 weeks of PBOO, there was an additional significant increase in bladder weight in all three groups.
   There was no difference in blood creatinine levels among the groups.
   In the 4- and 8- weekPBOO groups, there was a significant increase of 8-OHdG in urine and of MDA in plasma, while there was a significant decrease in TAC in plasma.
   CONCLUSION
   The results showed that oxidative stress could be detected in the plasma and urine of rabbits after 4 and 8 weeks of PBOO, and not only from bladder tissue as previously reported. Thus, there could be an easy and alternative way to evaluate bladder function by analysis of urine and/or plasma.
   Additionally, rabbits with chronic PBOO showed an increase in systemic oxidative stress, which could be a novel starting point for examining the link between the lower urinary tract symptoms/benign prostate hyperplasia and metabolic syndrome in future studies.
C1 [Wu, Shi-Bei; Wei, Yau-Huei] Natl Yang Ming Univ, Dept Biochem & Mol Biol, Taipei 112, Taiwan.
   [Lin, Wei-Yu; Chen, Chih-Shou; Lin, Yi-Pai; Levin, Robert M.] Chang Gung Med Fdn, Div Urol, Dept Surg, Chiayi, Taiwan.
   [Lin, Wei-Yu] Chang Gung Inst Technol, Chiayi, Taiwan.
   [Lin, Wei-Yu] Chang Gung Univ, Grad Inst Clin Med Sci, Coll Med, Tao Yuan, Taiwan.
   [Chen, Chih-Shou] Chang Gung Univ, Dept Urol, Tao Yuan, Taiwan.
   [Levin, Robert M.] Albany Coll Pharm & Hlth Sci, Albany, NY USA.
C3 National Yang Ming Chiao Tung University; Chang Gung Memorial Hospital;
   Chang Gung University of Science & Technology; Chang Gung University;
   Chang Gung University; Albany College of Pharmacy & Health Sciences
RP Wei, YH (corresponding author), Natl Yang Ming Univ, Dept Biochem & Mol Biol, Taipei 112, Taiwan.
EM joeman@ym.edu.tw
RI Chen, Yen-Chao/HDN-5326-2022; Lin, Wei Yu/KBD-1692-2024; TMU,
   barry0110/AAV-4030-2021; Wei, Yau-Huei/ABA-6841-2021
OI Chen, Chih-Shou/0000-0002-5785-2373; Wei, Yau-Huei/0000-0002-6429-2546
FU National Science Council of Taiwan [NSC 97-2314-B-182 A-078-MY2]; Chang
   Gung Medical Foundation of Taiwan [CMRP670361]
FX This research was supported by grants (NSC 97-2314-B-182 A-078-MY2) from
   the National Science Council of Taiwan and by grant (CMRP670361) from
   Chang Gung Medical Foundation of Taiwan.
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NR 30
TC 22
Z9 22
U1 0
U2 11
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1464-4096
EI 1464-410X
J9 BJU INT
JI BJU Int.
PD JUN
PY 2011
VL 107
IS 11
BP 1839
EP 1843
DI 10.1111/j.1464-410X.2010.09597.x
PG 5
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 766GW
UT WOS:000290770000021
PM 20875092
DA 2025-06-11
ER

PT J
AU Grillo, CA
   Piroli, GG
   Kaigler, KF
   Wilson, SP
   Wilson, MA
   Reagan, LP
AF Grillo, Claudia A.
   Piroli, Gerardo G.
   Kaigler, Kris F.
   Wilson, Steven P.
   Wilson, Marlene A.
   Reagan, Lawrence P.
TI Downregulation of hypothalamic insulin receptor expression elicits
   depressive-like behaviors in rats
SO BEHAVIOURAL BRAIN RESEARCH
LA English
DT Article
DE Obesity; Leptin; Brain-derived neurotrophic factor; Forced swim test;
   Elevated plus maze; Anhedonia
ID LONG-TERM POTENTIATION; BLOOD-BRAIN-BARRIER; MOOD DISORDERS; SYNAPTIC
   PLASTICITY; PROTEIN EXPRESSION; OPIOID-RECEPTORS; MESSENGER-RNA;
   ANIMAL-MODEL; LEPTIN; OBESITY
AB Ongoing epidemiological studies estimate that greater than 60% of the adult US population may be categorized as either overweight or obese. There is a growing appreciation that the complications of obesity extend to the central nervous system (CNS) and may result in increased risk for neurological comorbidities like depressive illness. One potential mechanistic mediator linking obesity and depressive illness is the adipocyte derived hormone leptin. We previously demonstrated that lentivirus-mediated downregulation of hypothalamic insulin receptors increases body weight, adiposity and plasma leptin levels, which is consistent with features of the metabolic syndrome. Using this novel model of obesity, we examined performance in the forced swim test (FST), the sucrose preference test and the elevated plus maze (EPM), approaches that are often used as measures of depressive-like and anxiety-like behaviors, in rats that received third ventricular injections of either an insulin receptor antisense lentivirus (hypo-IRAS) or a control lentivirus (hypo-Con). Hypo-IRAS rats exhibited significant increases in immobility time and corresponding decreases in active behaviors in the FST and exhibited anhedonia as measured by decreased sucrose intake compared to hypo-Con rats. Hypo-IRAS rats also exhibited increases in anxiety-like behaviors in the EPM. Plasma, hippocampal and amygdalar brain-derived neurotrophic factor (BDNF) levels were reduced in hypo-IRAS rats, suggesting that the obesity/hyperleptinemic phenotype may elicit this behavioral phenotype through modulation of neurotrophic factor expression. Collectively, these data support the hypothesis for an increased risk for mood disorders in obesity, which may be related to decreased expression of hippocampal and amygdalar BDNF. (C) 2011 Elsevier B.V. All rights reserved.
C1 [Grillo, Claudia A.; Piroli, Gerardo G.; Kaigler, Kris F.; Wilson, Steven P.; Wilson, Marlene A.; Reagan, Lawrence P.] Univ S Carolina, Sch Med, Dept Pharmacol Physiol & Neurosci, Columbia, SC 29208 USA.
C3 University of South Carolina System; University of South Carolina
   Columbia
RP Reagan, LP (corresponding author), Univ S Carolina, Sch Med, Dept Pharmacol Physiol & Neurosci, 6439 Garners Ferry Rd,D40, Columbia, SC 29208 USA.
EM lpreagan@uscmed.sc.edu
RI A Wilson, Marlene/JRW-2264-2023; Grillo, Claudia/J-6373-2012
OI Wilson, Marlene/0000-0003-4770-9669; Grillo, Claudia/0000-0001-9599-7234
FU NIH [NS047728, DK017844, MH086067, MH063344]; University of South
   Carolina Research Foundation
FX Supported by NIH grant numbers NS047728 (LPR), DK017844 (LPR), MH086067
   (LPR), MH063344 (MAW), and the University of South Carolina Research
   Foundation.
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NR 65
TC 89
Z9 95
U1 1
U2 13
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0166-4328
EI 1872-7549
J9 BEHAV BRAIN RES
JI Behav. Brain Res.
PD SEP 12
PY 2011
VL 222
IS 1
BP 230
EP 235
DI 10.1016/j.bbr.2011.03.052
PG 6
WC Behavioral Sciences; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Behavioral Sciences; Neurosciences & Neurology
GA 774WV
UT WOS:000291418400029
PM 21458499
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Rebollo-Hernanz, M
   Zhang, QZ
   Aguilera, Y
   Martín-Cabrejas, MA
   de Mejia, EG
AF Rebollo-Hernanz, Miguel
   Zhang, Qiaozhi
   Aguilera, Yolanda
   Martin-Cabrejas, Maria A.
   de Mejia, Elvira Gonzalez
TI Relationship of the Phytochemicals from Coffee and Cocoa By-Products
   with their Potential to Modulate Biomarkers of Metabolic Syndrome In
   Vitro
SO ANTIOXIDANTS
LA English
DT Article
DE phytochemicals; inflammation; oxidative stress; adipogenesis; insulin
   resistance; coffee by-products; cocoa by-products
ID BROWN ADIPOSE-TISSUE; MITOCHONDRIAL DYSFUNCTION; PROTOCATECHUIC ACID;
   INSULIN SENSITIVITY; OXIDATIVE STRESS; NITRIC-OXIDE; INFLAMMATION;
   ADIPOCYTES; BIOAVAILABILITY; POLYPHENOLS
AB This study aimed to compare the phytochemicals from coffee and cocoa by-products and their relationship with the potential for reducing markers of inflammation, oxidative stress, adipogenesis, and insulin resistance in vitro. We characterized the phytochemical profile of extracts from coffee husk, coffee silverskin, and cocoa shell and evaluated their in vitro biological activity in RAW264.7 macrophages and 3T3-L1 adipocytes. Pearson correlations and principal component regressions were performed to find the contribution of phytochemicals and underlying mechanisms of action. Coffee husk and silverskin extracts were mainly composed of caffeine and chlorogenic acid. Major components in cocoa shell included theobromine and protocatechuic acid. Both coffee and cocoa by-product extracts effectively reduced inflammatory markers in macrophages and adipocytes (NO, PGE(2), TNF-alpha, MCP-1, and IL-6) and the production of reactive oxygen species (21.5-66.4%). Protocatechuic and chlorogenic acids, together with caffeine, were suggested as main contributors against inflammation and oxidative stress. Furthermore, extracts reduced lipid accumulation (4.1-49.1%) in adipocytes by regulating lipolysis and inducing adipocyte browning. Gallic and chlorogenic acids were associated with reduced adipogenesis, and caffeine with adipocyte browning. Extracts from coffee and cocoa by-products also modulated the phosphorylation of insulin receptor signaling pathway and stimulated GLUT-4 translocation (52.4-72.9%), increasing glucose uptake. The insulin-sensitizing potential of the extracts was mainly associated with protocatechuic acid. For the first time, we identified the phytochemicals from coffee and cocoa by-products and offered new insights into their associations with biomarkers of inflammation, oxidative stress, adipogenesis, and insulin resistance in vitro.
C1 [Rebollo-Hernanz, Miguel; Aguilera, Yolanda; Martin-Cabrejas, Maria A.] UAM, CSIC, CIAL, Inst Food Sci Res, Madrid 28049, Spain.
   [Rebollo-Hernanz, Miguel; Aguilera, Yolanda; Martin-Cabrejas, Maria A.] Univ Autonoma Madrid, Dept Agr Chem & Food Sci, E-28049 Madrid, Spain.
   [Rebollo-Hernanz, Miguel; Zhang, Qiaozhi; de Mejia, Elvira Gonzalez] Univ Illinois, Dept Food Sci & Human Nutr, Urbana, IL 61801 USA.
   [Zhang, Qiaozhi] Zhejiang Gongshang Univ, Coll Food Sci & Biotechnol, Hangzhou 310000, Zhejiang, Peoples R China.
C3 Autonomous University of Madrid; Consejo Superior de Investigaciones
   Cientificas (CSIC); CSIC-UAM - Instituto de Investigacion en Ciencias de
   la Alimentacion (CIAL); Autonomous University of Madrid; University of
   Illinois System; University of Illinois Urbana-Champaign; Zhejiang
   Gongshang University
RP de Mejia, EG (corresponding author), Univ Illinois, Dept Food Sci & Human Nutr, Urbana, IL 61801 USA.
EM edemejia@illinois.edu
RI Martín-Cabrejas, María/L-6433-2014; GONZALEZ DE mEJIA,
   ELVIRA/IYI-9309-2023; Zhang, Qiaozhi/AAB-2540-2020; Rebollo-Hernanz,
   Miguel/S-6539-2019; aguilera, yolanda/B-6021-2012
OI Zhang, Qiaozhi/0000-0002-0578-4778; aguilera,
   yolanda/0000-0002-8724-6796; DE MEJIA, ELVIRA/0000-0001-7426-9035;
   Rebollo-Hernanz, Miguel/0000-0003-1034-1290
FU USDA-NIFA-HATCH project [1014457]; UAM-Santander [2017/EEUU/01]; FPU
   program of the Ministry of Science, Innovation, and Universities
   [FPU15/04238]; University of Illinois, Urbana-Champaign [EST17/00823,
   EST18/0064]
FX This research was founded by the USDA-NIFA-HATCH project to E.G.D.M.
   (1014457) and UAM-Santander (2017/EEUU/01). M. Rebollo-Hernanz received
   funding from the FPU program of the Ministry of Science, Innovation, and
   Universities for his predoctoral fellowship (FPU15/04238) and the
   support for the international research stays at the University of
   Illinois, Urbana-Champaign (EST17/00823, EST18/0064).
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NR 83
TC 49
Z9 50
U1 2
U2 31
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD AUG
PY 2019
VL 8
IS 8
AR 279
DI 10.3390/antiox8080279
PG 23
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA IT6CX
UT WOS:000482958900042
PM 31387271
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Van der Zwan, LP
   Scheffer, PG
   Dekker, JM
   Stehouwer, CDA
   Heine, RJ
   Teerlink, T
AF Van der Zwan, Leonard P.
   Scheffer, Peter G.
   Dekker, Jacqueline M.
   Stehouwer, Coen D. A.
   Heine, Robert J.
   Teerlink, Tom
TI Hyperglycemia and Oxidative Stress Strengthen the Association Between
   Myeloperoxidase and Blood Pressure
SO HYPERTENSION
LA English
DT Article
DE hypertension; diabetes; inflammation; nitric oxide; oxidized LDL
ID C-REACTIVE PROTEIN; NITRIC-OXIDE; SERUM MYELOPEROXIDASE;
   DIABETES-MELLITUS; NAD(P)H OXIDASE; RISK; POPULATION; PREDICT;
   DETERMINANTS; INFLAMMATION
AB Scavenging of the vasodilator nitric oxide by myeloperoxidase activity in the vasculature may contribute to hypertension. Because hydrogen peroxide is a cosubstrate of myeloperoxidase, hyperglycemia- induced oxidative stress may strengthen the relationship between myeloperoxidase and blood pressure. We investigated this relationship and its modification by hyperglycemia and oxidative stress in a population-based cohort of elderly subjects with normal glucose metabolism (n=267), impaired glucose metabolism (n=189), and type 2 diabetes (n=290). In an age- and sex-adjusted linear regression model, plasma myeloperoxidase was positively associated with systolic blood pressure (2.10 mm Hg per 1 SD increment of myeloperoxidase [95% CI: 0.66 to 3.54]), and this association was stronger at higher levels of fasting glucose (0.61 [-1.70 to 2.93], 1.33 [-1.43 to 4.10], and 3.42 [1.01 to 5.82] for increasing tertiles of glucose) and higher plasma levels of oxidized low-density lipoprotein (0.92[-1.31 to 3.14], 2.00 [-0.71 to 4.70], and 3.58 [0.98 to 6.19] for increasing tertiles of oxidized low-density lipoprotein). Likewise, the relationship between myeloperoxidase and blood pressure was strongest under conditions associated with oxidative stress, like obesity, low high-density lipoprotein cholesterol, metabolic syndrome, and type 2 diabetes. The strength of these associations was only marginally attenuated by adjustment for other cardiovascular risk factors. Our data demonstrate that myeloperoxidase is positively and independently associated with blood pressure, and this association is strongest in subjects with (hyperglycemiainduced) oxidative stress. These observations, together with emerging evidence that myeloperoxidase-derived oxidants contribute to the initiation and propagation of cardiovascular disease, identify myeloperoxidase as a promising target for drug development. (Hypertension. 2010;55:1366-1372.)
C1 [Van der Zwan, Leonard P.; Scheffer, Peter G.; Teerlink, Tom] Vrije Univ Amsterdam, Med Ctr, Dept Clin Chem, Metab Lab, NL-1007 MB Amsterdam, Netherlands.
   [Dekker, Jacqueline M.] Vrije Univ Amsterdam, Med Ctr, EMGO Inst, NL-1007 MB Amsterdam, Netherlands.
   [Heine, Robert J.] Vrije Univ Amsterdam, Med Ctr, Dept Endocrinol, NL-1007 MB Amsterdam, Netherlands.
   [Stehouwer, Coen D. A.] Maastricht Univ, Med Ctr, Dept Internal Med, Maastricht, Netherlands.
   [Stehouwer, Coen D. A.] Maastricht Univ, Med Ctr, Cardiovasc Res Inst Maastricht, Maastricht, Netherlands.
C3 Vrije Universiteit Amsterdam; Vrije Universiteit Amsterdam; Vrije
   Universiteit Amsterdam; Maastricht University; Maastricht University
RP Teerlink, T (corresponding author), Vrije Univ Amsterdam, Med Ctr, Dept Clin Chem, Metab Lab, Boelelaan 1117,POB 7057, NL-1007 MB Amsterdam, Netherlands.
EM t.teerlink@vumc.nl
RI Stehouwer, Coen/AAB-3435-2021
OI van der Zwan, Leonard Peter/0009-0001-2855-5900; Stehouwer,
   Coen/0000-0001-8752-3223
FU The Netherlands Organization for Health Research and Development; The
   Netherlands Heart Foundation; Dutch Diabetes Research Foundation
FX Throughout the years, the Hoorn Study was supported by research grants
   from The Netherlands Organization for Health Research and Development,
   The Netherlands Heart Foundation, and the Dutch Diabetes Research
   Foundation.
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NR 34
TC 51
Z9 55
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0194-911X
EI 1524-4563
J9 HYPERTENSION
JI Hypertension
PD JUN
PY 2010
VL 55
IS 6
BP 1366
EP 1372
DI 10.1161/HYPERTENSIONAHA.109.147231
PG 7
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 598OR
UT WOS:000277848100017
PM 20385972
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Rosa, FT
   Fatel, ECD
   Alfieri, DF
   Flauzino, T
   Scavuzzi, BM
   Lozovoy, MAB
   Iriyoda, TMV
   Simao, ANC
   Dichi, I
AF Rosa, Flavia Troncon
   Fatel, Elis Carolina de Souza
   Alfieri, Daniela Frizon
   Flauzino, Tamires
   Scavuzzi, Bruna Miglioranza
   Lozovoy, Marcell Alysson Batisti
   Iriyoda, Tatiana Mayumi Veiga
   Simao, Andrea Name Colado
   Dichi, Isaias
TI Cranberry juice decreases oxidative stress and improves glucose
   metabolism in patients with rheumatoid arthritis supplemented with fish
   oil
SO PHARMANUTRITION
LA English
DT Article
DE Rheumatoid arthritis; N-3 polyunsaturated fatty acids; Polyphenols;
   Carbohydrate metabolism; Lipid oxidation; Protein oxidation
ID PLASMA ANTIOXIDANT CAPACITY; POLYUNSATURATED FATTY-ACIDS; TRIGLYCERIDE
   TRANSFER PROTEIN; DOCOSAHEXAENOIC ACIDS; SERUM-LIPIDS;
   INSULIN-RESISTANCE; BLOOD-PRESSURE; DISEASE RISK; OMEGA-3-FATTY-ACIDS;
   CONSUMPTION
AB Background: Beneficial effects of fish oil n-3 polyunsaturated fatty acids (PUFAs) have been reported in rheu-matoid arthritis (RA), however, high doses of n-3 fatty acids have been associated with increased total and LDL cholesterol and impaired glucose metabolism. Cranberry products have been reported to improve markers of oxidative stress, inflammation, and the metabolic profile in patients with type 2 diabetes mellitus and with metabolic syndrome. We hypothesized that including low-energy cranberry juice on a regimen of fish oil sup-plementation could improve oxidative stress and attenuate the undesirable effects of fish oil in lipid and glucose metabolism in patients with RA.Methods: A 90-days randomized controlled trial was conducted. Patients (n = 70) were assigned to one of three groups: control (C); fish oil (FO) received 3 g of fish oil PUFAs supplementation/day; and fish oil and cranberry (FOCR) received 3 g of fish oil PUFAs and 500 mL of cranberry juice/day.Results: There was no difference in parameters between FO and the C. FOCR group showed decreased glucose (p = 0.0225), lipid (p = 0.0079), protein (p = 0.0063) oxidation, and Oxidative Stress Index (p = 0.0375) values compared to FO. FOCR reduced glucose values (p = 0.0104), triacylglycerol (p = 0.0065), protein oxidation (p = 0.0042) and Oxidative Stress Index (OSI) (p = 0.0053) compared to the C. Compared to baseline, FO group decreased triacylglycerol (p = 0.0374) and increased glucose (p 0.0001), whereas FOCR group decreased tri-acylglycerol (p = 0.0398) values.Conclusion: 500 mL/day of reduced-calorie cranberry juice in patients with RA using fish oil supplementation decreased lipid, protein oxidation and OSI.
C1 [Rosa, Flavia Troncon; Simao, Andrea Name Colado] Univ Londrina, Dept Pathol Clin Anal & Toxicol, Londrina, Parana, Brazil.
   [Fatel, Elis Carolina de Souza] Fed Univ South Border, Dept Nutr, Realeza, Parana, Brazil.
   [Alfieri, Daniela Frizon; Flauzino, Tamires; Scavuzzi, Bruna Miglioranza; Lozovoy, Marcell Alysson Batisti] Univ Estadual Londrina, Hlth Sci Ctr, Postgrad Program, Londrina, Parana, Brazil.
   [Iriyoda, Tatiana Mayumi Veiga] Londrina Univ Hosp, Londrina, Parana, Brazil.
   [Dichi, Isaias] Univ Londrina, Dept Internal Med, Londrina, Parana, Brazil.
   [Dichi, Isaias] Univ Londrina, Dept Internal Med, Rua Robert Koch 60 Bairro Cervejaria, Londrina, Parana, Brazil.
C3 Universidade Federal da Fronteira Sul; Universidade Estadual de Londrina
RP Dichi, I (corresponding author), Univ Londrina, Dept Internal Med, Rua Robert Koch 60 Bairro Cervejaria, Londrina, Parana, Brazil.
EM dichi@sercomtel.com.br
RI Rosa, Flávia/D-5263-2013; Simão, Andrea/AAM-4892-2021; Scavuzzi,
   Bruna/AAK-7916-2020; Alfieri, Daniela/LSI-6403-2024; Lozovoy,
   Marcell/AAM-4897-2021
OI Alfieri, Daniela/0000-0002-0217-9329
FU Brazilian National Council of Scientific and Technological Development
   (CNPq) [4768742013]
FX This research was funded by The Brazilian National Council of Scientific
   and Technological Development (CNPq) , grant number: 4768742013. The
   Juxx Company supplied the cranberry juice and had no role in the design,
   analysis or writing of this article.
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NR 59
TC 0
Z9 0
U1 1
U2 2
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2213-4344
J9 PHARMANUTRITION
JI PharmaNutrition
PD JUN
PY 2023
VL 24
AR 100341
DI 10.1016/j.phanu.2023.100341
EA MAR 2023
PG 8
WC Chemistry, Medicinal; Geriatrics & Gerontology; Gerontology; Nutrition &
   Dietetics; Pharmacology & Pharmacy
WE Emerging Sources Citation Index (ESCI)
SC Pharmacology & Pharmacy; Geriatrics & Gerontology; Nutrition & Dietetics
GA E2JB1
UT WOS:000973850300001
DA 2025-06-11
ER

PT J
AU Lastra, G
   Manrique, C
   Jia, G
   Aroor, AR
   Hayden, MR
   Barron, BJ
   Niles, B
   Padilla, J
   Sowers, JR
AF Lastra, Guido
   Manrique, Camila
   Jia, Guanghong
   Aroor, Annayya R.
   Hayden, Melvin R.
   Barron, Brady J.
   Niles, Brett
   Padilla, Jaume
   Sowers, James R.
TI Xanthine oxidase inhibition protects against Western diet-induced aortic
   stiffness and impaired vasorelaxation in female mice
SO AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE
   PHYSIOLOGY
LA English
DT Article
DE Western diet; vascular stiffness; females; oxidative stress; allopurinol
ID SERUM URIC-ACID; VASCULAR OXIDATIVE STRESS; ARTERIAL STIFFNESS;
   DIASTOLIC DYSFUNCTION; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   ENDOTHELIAL FUNCTION; CARDIOVASCULAR-DISEASE; SWEETENED BEVERAGES;
   POTENTIAL ROLE
AB Consumption of a high-fat, high-fructose diet [Western diet (WD)] promotes vascular stiffness, a critical factor in the development of cardiovascular disease (CVD). Obese and diabetic women exhibit greater arterial stiffness than men, which contributes to the increased incidence of CVD in these women. Furthermore, high-fructose diets result in elevated plasma concentrations of uric acid via xanthine oxidase (XO) activation, and uric acid elevation is also associated with increased vascular stiffness. However, the mechanisms by which increased xanthine oxidase activity and uric acid contribute to vascular stiffness in obese females remain to be fully uncovered. Accordingly, we examined the impact of XO inhibition on endothelial function and vascular stiffness in female C57BL/6J mice fed a WD or regular chow for 16 wk. WD feeding resulted in increased arterial stiffness, measured by atomic force microscopy in aortic explants (16.19 +/- 1.72 vs. 5.21 +/- 0.54 kPa, P < 0.05), as well as abnormal aortic endothelium-dependent and-independent vasorelaxation. XO inhibition with allopurinol (widely utilized in the clinical setting) substantially improved vascular relaxation and attenuated stiffness (16.9 +/- 0.50 vs. 3.44 +/- 0.50 kPa, P < 0.05) while simultaneously lowering serum uric acid levels (0.55 +/- 0.98 vs. 0.21 +/- 0.04 mg/dL, P < 0.05). In addition, allopurinol improved WD-induced markers of fibrosis and oxidative stress in aortic tissue, as analyzed by immunohistochemistry and transmission electronic microscopy. Collectively, these results demonstrate that XO inhibition protects against WD-induced vascular oxidative stress, fibrosis, impaired vasorelaxation, and aortic stiffness in females. Furthermore, excessive oxidative stress resulting from XO activation appears to play a key role in mediating vascular dysfunction induced by chronic exposure to WD consumption in females.
C1 [Lastra, Guido; Manrique, Camila; Jia, Guanghong; Aroor, Annayya R.; Hayden, Melvin R.; Barron, Brady J.; Niles, Brett; Sowers, James R.] Univ Missouri, Dept Med, Div Endocrinol, Columbia, MO USA.
   [Lastra, Guido; Manrique, Camila; Jia, Guanghong; Aroor, Annayya R.; Hayden, Melvin R.; Barron, Brady J.; Niles, Brett; Sowers, James R.] Univ Missouri, MU Diabet & Cardiovasc Res Ctr, Columbia, MO USA.
   [Lastra, Guido; Manrique, Camila; Jia, Guanghong; Aroor, Annayya R.; Hayden, Melvin R.; Barron, Brady J.; Niles, Brett; Sowers, James R.] Univ Missouri, Harry S Truman Mem Vet Hosp, Sch Med, Res Serv, Columbia, MO USA.
   [Padilla, Jaume] Univ Missouri, Dalton Cardiovasc Res Ctr, Columbia, MO USA.
   [Padilla, Jaume] Univ Missouri, Dept Nutr & Exercise Physiol, Columbia, MO USA.
   [Padilla, Jaume] Univ Missouri, Dept Child Hlth, Columbia, MO 65201 USA.
   [Sowers, James R.] Univ Missouri, Dept Med Pharmacol & Physiol, Columbia, MO USA.
C3 University of Missouri System; University of Missouri Columbia;
   University of Missouri System; University of Missouri Columbia; US
   Department of Veterans Affairs; Veterans Health Administration (VHA);
   Harry S. Truman Memorial Veterans' Hospital; University of Missouri
   System; University of Missouri Columbia; University of Missouri System;
   University of Missouri Columbia; University of Missouri System;
   University of Missouri Columbia; University of Missouri System;
   University of Missouri Columbia; University of Missouri System;
   University of Missouri Columbia
RP Lastra, G (corresponding author), Harry S Truman Mem Vet Hosp, MU Diabet & Cardiovasc Res Ctr, Dept Med, Div Endocrinol, One Hosp Dr, Columbia, MO 65212 USA.
EM lastrag@health.missouri.edu
OI Barron, Brady/0000-0002-6938-3789; lastra, guido/0000-0001-9205-1021
FU National Institutes of Health [1-K08-HL-132012-01A1, 1-K08-HL-129074-01,
   K01-HL-125503, R21-DK-105368, R01-HL-073101, R01-HL-107910]; Department
   of Veterans Affairs Merit Award [1BX001981]
FX This work was supported by the National Institutes of Health
   (1-K08-HL-132012-01A1 to G. Lastra, 1-K08-HL-129074-01 to C. Manrique,
   K01-HL-125503 and R21-DK-105368 to J. Padilla, and R01-HL-073101 and
   R01-HL-107910 to J. R. Sowers) and a Department of Veterans Affairs
   Merit Award (1BX001981 to J. R. Sowers).
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NR 77
TC 23
Z9 24
U1 0
U2 5
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0363-6119
EI 1522-1490
J9 AM J PHYSIOL-REG I
JI Am. J. Physiol.-Regul. Integr. Comp. Physiol.
PD AUG
PY 2017
VL 313
IS 2
BP R67
EP R77
DI 10.1152/ajpregu.00483.2016
PG 11
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA FD4KJ
UT WOS:000407499700002
PM 28539355
OA Green Published
DA 2025-06-11
ER

PT J
AU Kaplowitz, ET
   Savenkova, M
   Karatsoreos, IN
   Romeo, RD
AF Kaplowitz, E. T.
   Savenkova, M.
   Karatsoreos, I. N.
   Romeo, R. D.
TI Somatic and Neuroendocrine Changes in Response to Chronic Corticosterone
   Exposure During Adolescence in Male and Female Rats
SO JOURNAL OF NEUROENDOCRINOLOGY
LA English
DT Article
DE adolescent; puberty; maturation; oral corticosterone
ID DIETARY-INDUCED OBESITY; METABOLIC SYNDROME; FOOD-INTAKE; STRESS;
   GLUCOCORTICOIDS; RESPONSIVENESS; RESTRAINT; NICOTINE; BRAIN; MODEL
AB Prolonged stress and repeated activation of the hypothalamic-pituitary-adrenal axis can result in many sex-dependent behavioural and metabolic changes in rats, including alterations in feeding behaviour and reduced body weight. In adults, these effects of stress can be mimicked by corticosterone, a major output of the hypothalamic-pituitary-adrenal axis, and recapitulate the stress-induced sex difference, such that corticosterone-treated males show greater weight loss than females. Similar to adults, chronic stress during adolescence leads to reduced weight gain, particularly in males. However, it is currently unknown whether corticosterone mediates this somatic change and whether additional measures of neuroendocrine function are affected by chronic corticosterone exposure during adolescence in a sex-dependent manner. Therefore, we examined the effects of non-invasively administered corticosterone (150 or 300g/ml) in the drinking water of male and female rats throughout adolescent development (30-58days of age). We found that adolescent animals exposed to chronic corticosterone gain significantly less weight than controls, which may be partly mediated by the effects of corticosterone on food consumption, fluid intake and gonadal hormone function. Our data further show that, despite similar circulating corticosterone levels, males demonstrate a greater sensitivity to these changes than females. We also found that Npy1 and Npy5 receptor mRNA expression, genes implicated in appetite regulation, was significantly reduced in the ventral medial hypothalamus of corticosterone-treated males and females compared to controls. Finally, parameters of gonadal function, such as plasma sex steroid concentrations and weight of reproductive tissues, were reduced by adolescent corticosterone treatment, although only in males. The data obtained in the present study indicate that chronic corticosterone exposure throughout adolescent development results in significant and sex-dependent somatic and neuroendocrine changes, and the results also provide an experimental framework for further investigating the impact of corticosterone on metabolic and neuroendocrine function during adolescence.
C1 [Kaplowitz, E. T.; Romeo, R. D.] Columbia Univ, Barnard Coll, Dept Psychol, New York, NY 10027 USA.
   [Kaplowitz, E. T.; Romeo, R. D.] Columbia Univ, Barnard Coll, Neurosci & Behav Program, New York, NY 10027 USA.
   [Savenkova, M.; Karatsoreos, I. N.] Washington State Univ, Dept Integrat Physiol & Neurosci, Pullman, WA 99164 USA.
C3 Columbia University; Barnard College; Barnard College; Columbia
   University; Washington State University
RP Romeo, RD (corresponding author), Columbia Univ, Barnard Coll, Dept Psychol, New York, NY 10027 USA.; Romeo, RD (corresponding author), Columbia Univ, Barnard Coll, Neurosci & Behav Program, New York, NY 10027 USA.
EM rromeo@barnard.edu
RI Karatsoreos, Ilia/AAR-8774-2020; Savenkova, Marina/AAN-9927-2021
OI Kaplowitz, Elianna/0000-0002-2769-209X
CR Almeida SA, 2000, ANDROLOGIA, V32, P7
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NR 29
TC 17
Z9 17
U1 0
U2 13
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0953-8194
EI 1365-2826
J9 J NEUROENDOCRINOL
JI J. Neuroendocrinol.
PD FEB
PY 2016
VL 28
IS 2
DI 10.1111/jne.12336
PG 8
WC Endocrinology & Metabolism; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology
GA DF5ZS
UT WOS:000371434100001
PM 26568535
DA 2025-06-11
ER

PT J
AU Veilleux, A
   Grenier, É
   Marceau, P
   Carpentier, AC
   Richard, D
   Levy, E
AF Veilleux, Alain
   Grenier, Emilie
   Marceau, Picard
   Carpentier, Andre C.
   Richard, Denis
   Levy, Emile
TI Intestinal Lipid Handling Evidence and Implication of Insulin Signaling
   Abnormalities in Human Obese Subjects
SO ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
LA English
DT Article
DE diabetes mellitus; type 2; dyslipidemias; inflammation; intestines;
   oxidative stress
ID NF-KAPPA-B; LIPOPROTEIN OVERPRODUCTION; DIABETES-MELLITUS;
   ENDOTHELIAL-CELLS; REMNANT LIPOPROTEINS; APOLIPOPROTEIN B-48;
   PSAMMOMYS-OBESUS; OXIDATIVE STRESS; GASTRIC BYPASS; ANIMAL-MODEL
AB Objective Animal models have evidenced the role of intestinal triglyceride-rich lipoprotein overproduction in dyslipidemia. However, few studies have confronted this issue in humans and disclosed the intrinsic mechanisms. This work aimed to establish whether intestinal insulin resistance modifies lipid and lipoprotein homeostasis in the intestine of obese subjects.
   Approach and Results Duodenal specimens obtained from 20 obese subjects undergoing bariatric surgery were paired for age, sex, and body mass index with or without insulin resistance, as defined by the homeostasis model assessment of insulin resistance. Insulin signaling, biomarkers of inflammation and oxidative stress, and lipoprotein assembly were assessed. The intestine of insulin-resistant subjects showed defects in insulin signaling as demonstrated by reduced protein kinase B phosphorylation and increased p38 mitogen-activated protein kinase phosphorylation, likely as the result of high oxidative stress (evidenced by malondialdehyde and conjugated dienes) and inflammation (highlighted by nuclear factor-B, tumor necrosis factor-, interleukin-6, intercellular adhesion molecule-1, and cyclooxygenase-2). Enhanced de novo lipogenesis rate and apolipoprotein B-48 biogenesis along with exaggerated triglyceride-rich lipoprotein production were observed, concomitantly with the high expression levels of liver and intestinal fatty acid-binding proteins and microsomal transfer protein. The presence of an aberrant intracellular cholesterol transport/metabolism was also suggested by the reduced expression of ATP-binding cassette A1 transporter and proprotein convertase subtilisin/kexin type 9.
   Conclusions According to the present data, the small intestine may be classified as an insulin-sensitive tissue. Dysregulation of intestinal insulin signaling, possibly triggered by oxidative stress and inflammation, was associated with exaggerated lipogenesis and lipoprotein synthesis, which may represent a key mechanism for atherogenic dyslipidemia in patients with metabolic syndrome.
C1 [Veilleux, Alain; Grenier, Emilie; Levy, Emile] Univ Montreal, Dept Nutr, Res Ctr, CHU St Justine, Montreal, PQ H3C 3J7, Canada.
   [Marceau, Picard] Univ Laval, Dept Surg, Quebec City, PQ, Canada.
   [Carpentier, Andre C.] Univ Sherbrooke, Dept Med, CHU Sherbrooke, Sherbrooke, PQ J1K 2R1, Canada.
   [Richard, Denis] Inst Univ Cardiol & Pneumol Quebec, Ctr Rech, Quebec City, PQ, Canada.
   [Levy, Emile] Hop St Justine, Lab Lipidol Metab & Nutr, Montreal, PQ H3T 1C5, Canada.
C3 Universite de Montreal; Centre Hospitalier Universitaire Sainte-Justine;
   Laval University; University of Sherbrooke; Laval University; Laval
   University Hospital; Universite de Montreal
RP Levy, E (corresponding author), Hop St Justine, Lab Lipidol Metab & Nutr, 3175 Cote Ste Catherine Rd, Montreal, PQ H3T 1C5, Canada.
EM emile.levy@recherche-ste-justine.qc.ca
RI Veilleux, Alain/I-5028-2019
OI Veilleux, Alain/0000-0003-4078-1908
FU Canadian Institutes of Health Research [MOP 10584, MOP 49433]; J.A. de
   Seve Research Chair in Nutrition; Canadian Institutes of Health
   Research; Canadian Diabetes Association
FX The study was supported by operating funds from the Canadian Institutes
   of Health Research (MOP 10584 and MOP 49433) and J.A. de Seve Research
   Chair in Nutrition ( to E. L.). A. V. was supported by a postdoctoral
   studentship from the Canadian Institutes of Health Research and the
   Canadian Diabetes Association.
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NR 57
TC 60
Z9 71
U1 0
U2 8
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1079-5642
EI 1524-4636
J9 ARTERIOSCL THROM VAS
JI Arterioscler. Thromb. Vasc. Biol.
PD MAR
PY 2014
VL 34
IS 3
BP 644
EP 653
DI 10.1161/ATVBAHA.113.302993
PG 10
WC Hematology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Hematology; Cardiovascular System & Cardiology
GA AD1LX
UT WOS:000332996600022
PM 24407032
OA Bronze
DA 2025-06-11
ER

PT J
AU Kazemi, A
   Ramezanzadeh, F
   Nasr-Esfahani, MH
   Yaraghi, AAS
   Ahmadi, M
AF Kazemi, Ashraf
   Ramezanzadeh, Fatemeh
   Nasr-Esfahani, Mohammad Hosein
   Yaraghi, Ali Akbar Saboor
   Ahmadi, Mehdi
TI Does dietary fat intake influence oocyte competence and embryo quality
   by inducing oxidative stress in follicular fluid?
SO IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE
LA English
DT Article
DE Dietary Fat; Oxidative stress; Follicular fluid; Oocyte competence;
   Embryo Quality; Malon-de-aldeid; Total antioxidant capacity
ID IN-VITRO FERTILIZATION; INDUCED METABOLIC SYNDROME; ANTIOXIDANT ENZYMES;
   HIGH-CARBOHYDRATE; POTENTIAL ROLE; FREE-RADICALS; GLUTATHIONE;
   MATURATION; INSULIN; SERUM
AB Background: Fat-rich diet may alter oocyte development and maturation and embryonic development by inducing oxidative stress (OS) in follicular environment.
   Objective: To investigate the relationship between fat intake and oxidative stress with oocyte competence and embryo quality.
   Materials and Methods: In observational study follicular fluid was collected from 236 women undergoing assisted reproduction program. Malon-di-aldehyde (MDA) levels and total antioxidant capacity (TAC) levels of follicular fluid were assessed as oxidative stress biomarkers. In assisted reproduction treatment cycle fat consumption and its component were assessed. A percentage of metaphase.. stage oocytes, fertilization rate were considered as markers of oocyte competence and non-fragmented embryo rate, mean of blastomer and good cleavage (embryos with more than 5 cells on 3 days post insemination) rate were considered as markers of embryo quality.
   Results: The MDA level in follicular fluid was positively related to polyunsaturated fatty acids intake level (p=0.02) and negatively associated with good cleavage rate (p=0.045). Also good cleavage rate (p=0.005) and mean of blastomer (p=0.006) was negatively associated with polyunsaturated fatty acids intake levels. The percentage of metaphase.. stage oocyte was positively related to the TAC levels in follicular fluid (p=0.046). The relationship between the OS biomarkers in FF and the fertilization rate was not significant.
   Conclusion: These findings revealed that fat rich diet may induce the OS in oocyte environment and negatively influence embryonic development. This effect can partially be accounted by polyunsaturated fatty acids uptake while oocyte maturation is related to TAC and oocytes with low total antioxidant capacity have lower chance for fertilization and further development.
C1 [Kazemi, Ashraf] Isfahan Univ Med Sci, Fac Nursing & Midwifery, Nursing & Midwifery Care Res Ctr, Esfahan 817473461, Iran.
   [Ramezanzadeh, Fatemeh] Univ Tehran Med Sci, Vali E Asr Reprod Hlth Res Ctr, Tehran, Iran.
   [Nasr-Esfahani, Mohammad Hosein] ACECR, Royan Inst Anim Biotechnol, Dept Reprod & Dev, Reprod Biomed Ctr, Esfahan, Iran.
   [Yaraghi, Ali Akbar Saboor] Univ Tehran Med Sci, Sch Publ Hlth, Dept Biochem & Nutr, Tehran, Iran.
   [Ahmadi, Mehdi] Isfahan Fertil & Infertil Ctr, Esfahan, Iran.
C3 Isfahan University of Medical Sciences; Tehran University of Medical
   Sciences; Academic Center for Education, Culture & Research (ACECR);
   Tehran University of Medical Sciences
RP Kazemi, A (corresponding author), Isfahan Univ Med Sci, Hezarjeri St, Esfahan 817473461, Iran.
EM Kazemi@nm.mui.ac.ir
RI Najafabadi, Mehdi/AAA-5426-2021; Nasr-Esfahani, Mohammad/AAN-2577-2020;
   Kazemi, Ashraf/E-6495-2012
FU Tehran University of Medical Sciences [10603280289]
FX The authors appreciate Tehran University of Medical Sciences for funding
   the survey (Grant No. 10603280289).
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NR 50
TC 26
Z9 27
U1 0
U2 4
PU SHAHID SADOUGHI UNIV MEDICAL SCIENCES YAZD, IRAN
PI YAZD
PA HEMATOLOGY & ONCOLOGY RES CTR, 1ST FLR, BAGHAIEE POUR CLINIC, SHAHID
   SADOUGHI HOSP, EBNE SINA AVE, YAZD, SAFAIEEH 8915887857, IRAN
SN 1680-6433
EI 2008-2177
J9 IRAN J REPROD MED
JI Iran. J. Reprod. Med.
PD DEC
PY 2013
VL 11
IS 12
BP 1005
EP 1012
PG 8
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA 297WH
UT WOS:000330285300007
PM 24639727
DA 2025-06-11
ER

PT J
AU Jorgensen, JM
   Yang, ZY
   Lönnerdal, B
   Chantry, CJ
   Dewey, KG
AF Jorgensen, Josh M.
   Yang, Zhenyu
   Lonnerdal, Bo
   Chantry, Caroline J.
   Dewey, Kathryn G.
TI Effect of iron supplementation during lactation on maternal iron status
   and oxidative stress: A randomized controlled trial
SO MATERNAL AND CHILD NUTRITION
LA English
DT Article
DE breastfeeding; inflammation; iron; lactation; oxidative stress;
   postpartum
ID LOW-DENSITY-LIPOPROTEIN; DNA-DAMAGE; LIPID-PEROXIDATION; ANTIOXIDANT
   STATUS; METABOLIC SYNDROME; SERUM FERRITIN; BODY IRON; IN-VIVO;
   MULTIVITAMIN/MULTIMINERAL SUPPLEMENTS; OXIDIZED CHOLESTEROL
AB We examined the effect of iron-containing prenatal vitamin-mineral supplements taken postpartum on biomarkers of iron status and oxidative stress. Lactating women (n = 114) were randomly assigned to consume daily one iron-free prenatal vitamin-mineral supplement plus either 27 mg of iron or placebo for approximately 3.5 months. The placebo group took the tablets between meals, while those given iron took the tablets either with (Fe-W) or between meals (Fe-B). Blood and urine samples were collected before and after the supplementation period to analyze hemoglobin (Hb), ferritin, hepcidin, transferrin saturation (TfSat), total plasma iron, and biomarkers of oxidative stress (isoprostane and 8-hydroxy-2-deoxyguanosine (8-OHdG)) and inflammation (Creactive protein (CRP) and alpha-1-acid glycoprotein (AGP)). There was a trend toward a greater change in Hb among women in the Fe-B group compared to placebo (+ 2.5 vs. -3.7 g/L, respectively, p = 0.063). When the iron groups were combined, there was a greater change in Hb (+ 1.4 g/L) compared to placebo (p = 0.010). There were trends toward greater changes in TfSat (p = 0.087) and total plasma iron (p = 0.065) in the iron groups compared to placebo, yet no significant differences between the three groups in change in hepcidin (p = 0.291), isoprostane (p = 0.319), or 8-OHdG (p = 0.659), nor in change in ferritin among those with elevated CRP at baseline (60% of women; p = 0.946); among those without elevated CRP (40% of women), ferritin increased more in the iron groups compared to placebo (p = 0.001). Iron consumption during lactation moderately increased iron status, particularly among women without elevated CRP, and increased Hb, but did not significantly increase oxidative stress.
C1 [Jorgensen, Josh M.; Lonnerdal, Bo; Dewey, Kathryn G.] Univ Calif Davis, Dept Nutr, One Shields Ave, Davis, CA 95616 USA.
   [Yang, Zhenyu] Chinese Ctr Dis Control & Prevent, Natl Inst Nutr & Hlth, Beijing, Peoples R China.
   [Yang, Zhenyu] Minist Hlth China, Key Lab Trace Element Nutr, Beijing, Peoples R China.
   [Chantry, Caroline J.] Univ Calif Davis, Med Ctr, Dept Pediat, Sacramento, CA 95817 USA.
C3 University of California System; University of California Davis; Chinese
   Center for Disease Control & Prevention; University of California
   System; University of California Davis
RP Dewey, KG (corresponding author), Univ Calif Davis, Dept Nutr, One Shields Ave, Davis, CA 95616 USA.
EM kgdewey@ucdavis.edu
RI Chantry, Caroline/AAY-4011-2021
FU Center for Health and Nutrition Research at UC Davis
FX Funding was provided by the Center for Health and Nutrition Research at
   UC Davis.
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NR 75
TC 8
Z9 8
U1 0
U2 11
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1740-8695
EI 1740-8709
J9 MATERN CHILD NUTR
JI Matern. Child Nutr.
PD OCT
PY 2017
VL 13
IS 4
AR e12394
DI 10.1111/mcn.12394
PG 11
WC Nutrition & Dietetics; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics; Pediatrics
GA FI1TX
UT WOS:000411718600015
PM 27896921
OA Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Tian, T
   Liu, XR
   Li, TT
   Nie, ZC
   Li, SJ
   Tang, Y
   Gu, CW
   Xu, WD
   Jia, H
AF Tian, Tian
   Liu, Xi-run
   Li, Ting-ting
   Nie, Zhi-chao
   Li, Shuang-jing
   Tang, Yan
   Gu, Cong-wei
   Xu, Wang-dong
   Jia, Hong
TI Detrimental effects of long-term elevated serum uric acid on cognitive
   function in rats
SO SCIENTIFIC REPORTS
LA English
DT Article
ID ALZHEIMERS-DISEASE; OXIDATIVE STRESS; HIPPOCAMPAL INFLAMMATION;
   METABOLIC SYNDROME; IN-VITRO; ASSOCIATION; IMPAIRMENT; RISK;
   NEUROINFLAMMATION; DYSFUNCTION
AB Uric acid is a powerful antioxidant. However, its elevated levels in association with cardiovascular diseases predispose individuals to cognitive impairment. Uric acid's effects on cognition may be related to its concentration and exposure period. We aimed to explore the effects of long-term elevated serum uric acid on cognitive function and hippocampus. Rats were randomly divided into four groups: NC, M1, M2 and M3 groups. Hyperuricemia was established in rats at week 6 and maintained until week 48 in groups M1, M2 and M3. The rats' spatial learning and memory abilities were assessed by the Morris Water Maze test at weeks 0, 6, 16, 32, and 48. After week 48, we observed pathological changes in right hippocampal CA1 and CA3 regions, and measured levels of oxidative stress, inflammatory cytokines, and beta -amyloid peptide of left hippocampus. Starting from week 6, the serum uric acid level of M3 group >M2 group, the serum uric acid level of M2 group >M1 group, and the serum uric acid level of M1 group >NC group. The rats in M3 and M2 groups had longer escape latencies, longer mean distances to the platform, more extensive pathological damage, stronger inflammation response, higher oxidative stress and beta -amyloid peptide levels than those in NC group. No significant differences were observed between M1 and NC groups. In addition, we also found that oxidative stress significantly correlated with tumour necrosis factor-alpha and beta -amyloid peptide. Long-term elevated serum uric acid was significantly associated with cognitive impairment risk. Oxidative stress, tumour necrosis factor-alpha and beta -amyloid peptide may mediate the pathogenesis of the cognitive impairment induced by uric acid. The detrimental effect of elevated serum uric acid on cognitive function was probably expressed when the serum uric acid concentration reached a certain level.
C1 [Tian, Tian; Li, Ting-ting; Nie, Zhi-chao; Li, Shuang-jing; Tang, Yan; Xu, Wang-dong; Jia, Hong] Southwest Med Univ, Sch Publ Hlth, Luzhou 646000, Peoples R China.
   [Liu, Xi-run] Southwest Med Univ, Affiliated Hosp, Clin Drug Trial Inst, Luzhou 646000, Peoples R China.
   [Gu, Cong-wei] Southwest Med Univ, Lab Anim Ctr, Luzhou 646000, Peoples R China.
   [Jia, Hong] Minist Educ, Key Lab Med Electrophysiol, Collaborat Innovat Ctr Prevent Cardiovasc Res Sic, Luzhou 646000, Peoples R China.
C3 Southwest Medical University; Southwest Medical University; Southwest
   Medical University; Ministry of Education - China
RP Jia, H (corresponding author), Southwest Med Univ, Sch Publ Hlth, Luzhou 646000, Peoples R China.; Jia, H (corresponding author), Minist Educ, Key Lab Med Electrophysiol, Collaborat Innovat Ctr Prevent Cardiovasc Res Sic, Luzhou 646000, Peoples R China.
EM jhong_lz@163.com
RI Li, Tingting/GPK-7292-2022; , Hong/C-8795-2011
OI , Hong/0000-0001-7617-1146
FU Department of Science and Technology of the Sichuan Province
   [2015JY0063]
FX This work received a Grant from the Department of Science and Technology
   of the Sichuan Province [Grant number 2015JY0063]. Also, the authors
   wish to thank Ms Jia for her excellent editorial assistance in
   manuscript preparation.
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NR 51
TC 22
Z9 22
U1 1
U2 8
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD MAR 24
PY 2021
VL 11
IS 1
AR 6732
DI 10.1038/s41598-021-86279-y
PG 9
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA RF6RN
UT WOS:000634969500021
PM 33762656
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Elmas, B
   Karacan, M
   Dervisoglu, P
   Kösecik, M
   Isgüven, SP
   Bal, C
AF Elmas, Bahri
   Karacan, Mehmet
   Dervisoglu, Pinar
   Kosecik, Mustafa
   Isguven, Sukriye Pinar
   Bal, Ceylan
TI Dynamic thiol/disulphide homeostasis as a novel indicator of oxidative
   stress in obese children and its relationship with
   inflammatory-cardiovascular markers
SO ANATOLIAN JOURNAL OF CARDIOLOGY
LA English
DT Article
DE cardiovascular risk; children; inflammation; obesity; oxidative stress;
   thiol/disulphide homeostasis
ID THIOL-DISULFIDE HOMEOSTASIS; REDUCED ANTIOXIDANT CAPACITY;
   LEFT-VENTRICULAR MASS; METABOLIC SYNDROME; CHILDHOOD OBESITY;
   RISK-FACTORS; DISEASE; ASSOCIATION; ADOLESCENTS; OVERWEIGHT
AB Objective: Childhood obesity is an important cause of cardiovascular risk with chronic inflammation. Oxidative stress may contribute to the pathogenesis of obesity-related cardiovascular pathologies. We aimed to evaluate thiol/disulphide homeostasis as a novel and sensitive marker of oxidative stress and to evaluate its relationship with some inflammatory and cardiovascular markers in obese children.
   Methods: In this case-controlled study, 65 children with exogenous obesity and 64 healthy children, as a control group, were included. In both groups, thiol/disulphide homeostasis parameters and inflammatory (white blood cells, platelets, mean corpuscular volume, neutrophil/lymphocyte ratio, and high-sensitivity C-reactive protein) and cardiovascular (epicardial adipose tissue thickness and left ventricular mass index) markers were studied. Correlation analyses of thiol/disulphide homeostasis parameters with body mass index standard deviation scores (BMI SDS) and inflammatory and cardiovascular markers were performed. Receiver-operating characteristic analysis was performed to determine the sensitivity, specificity, and optimal cut-off values of thiol/disulphide homeostasis parameters.
   Results: Native thiol, total thiol, and native thiol/total thiol ratios (antioxidant parameters) were lower (p<0.05) and disulphide/native thiol and disulphide/total thiol ratios (oxidant parameters) were higher in the obese group than in the control group (p<0.01). A positive correlation of oxidant parameters with BMI SDS and inflammatory markers was found. However, a negative correlation of antioxidant parameters with BMI SDS and inflammatory markers was found. The specificities of disulphide/native thiol and disulphide/total thiol ratios were higher in the obese group.
   Conclusion: The impairment in thiol/disulphide homeostasis, which is indicative of oxidative stress, is associated with inflammation in obesity. In addition, cardiovascular involvement may also contribute to this impairment.
C1 [Elmas, Bahri] Sakarya Univ, Fac Med, Dept Pediat, Sakarya, Turkey.
   [Dervisoglu, Pinar; Kosecik, Mustafa] Sakarya Univ, Fac Med, Dept Pediat Cardiol, Sakarya, Turkey.
   [Isguven, Sukriye Pinar] Sakarya Univ, Fac Med, Dept Pediat Endocrinol, Sakarya, Turkey.
   [Karacan, Mehmet] Medipol Univ, Fac Med, Dept Pediat Cardiol, Istanbul, Turkey.
   [Bal, Ceylan] Yildirim Beyazit Univ, Fac Med, Dept Biochem, Ankara, Turkey.
C3 Sakarya University; Sakarya University; Sakarya University; Istanbul
   Medipol University; Ankara Yildirim Beyazit University
RP Elmas, B (corresponding author), Sakarya Univ, Fac Med, Dept Pediat, Sakarya, Turkey.
EM bahrielmas@gmail.com
RI elmas, bahri/ABB-7465-2020; Bal, Ceylan/AAC-4414-2020; Dervişoğlu
   Çavdaroğlu, Pınar/AAC-5971-2020
OI Bal, Ceylan/0000-0002-1678-1281
CR Altiparmak IH, 2016, KARDIOL POL, V74, P1346, DOI 10.5603/KP.a2016.0085
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NR 39
TC 32
Z9 33
U1 0
U2 11
PU TURKISH SOC CARDIOLOGY
PI BAHCELIEVLER
PA COBANCESME SANAYI CAD NO 11, NISH ISTANBUL A BLOK KAT 8 NO 47-48,
   YENIBOSNA, BAHCELIEVLER, ISTANBUL 34196, TURKEY
SN 2149-2263
EI 2149-2271
J9 ANATOL J CARDIOL
JI Anat. J. Cardiol.
PD NOV
PY 2017
VL 18
IS 5
BP 361
EP 369
DI 10.14744/AnatolJCardiol.2017.7740
PG 9
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA FP8FI
UT WOS:000417875700012
PM 28761018
OA Green Submitted, gold, Green Published
DA 2025-06-11
ER

PT J
AU Bartoli, F
   Crocamo, C
   Alamia, A
   Amidani, F
   Paggi, E
   Pini, E
   Clerici, M
   Carrà, G
AF Bartoli, Francesco
   Crocamo, Cristina
   Alamia, Alberto
   Amidani, Francesca
   Paggi, Elisabetta
   Pini, Elena
   Clerici, Massimo
   Carra, Giuseppe
TI Posttraumatic Stress Disorder and Risk of Obesity: Systematic Review and
   Meta-Analysis
SO JOURNAL OF CLINICAL PSYCHIATRY
LA English
DT Article
DE Posttraumatic Stress Disorder; Weight
ID PERSISTENT MENTAL-ILLNESS; METABOLIC SYNDROME; BIPOLAR DISORDER;
   PHYSICAL ILLNESS; TRAUMATIC STRESS; DSM-IV; PREVALENCE; PTSD;
   ASSOCIATION; PEOPLE
AB Objective: To examine the association between posttraumatic stress disorder (PTSD) and obesity in the literature to date.
   Data Sources: We systematically searched PubMed, Embase, Scopus, Web of Science, and ProQuest from database inception until September 2013. Search phrases combining the terms Obesity and Post-Traumatic Stress Disorder were used.
   Study Selection: We selected observational studies estimating obesity prevalence in samples of people with PTSD, as well as in comparison groups without PTSD.
   Data Extraction: Obesity rates as well as demographic, clinical, and methodological variables were extracted from each publication or obtained directly from its authors.
   Results: A total of 113, 395, 59, 115, and 400 records were generated from PubMed, Embase, Scopus, Web of Science, and ProQuest, respectively. Thirteen studies were eligible according to inclusion criteria. The pooled crude odds ratio (OR) and 95% confidence interval (CI) for obesity among people with PTSD, based on 589,781 subjects, was 1.55 (1.32-1.82). A large heterogeneity was found (I-2 = 90%), and risk of publication bias was statistically significant (P = .002). However, subgroup and sensitivity analyses including only studies with most accurate methods to assess obesity (OR = 1.35; 95% CI, 1.05-1.74; I-2 = 47%) and PTSD (OR = 1.82; 95% CI, 1.33-2.50; I-2 = 75%) also confirmed the association between PTSD and obesity.
   Conclusions: Despite some limitations, individuals suffering from PTSD seem more likely, relative to controls, to suffer from obesity. As such, individuals with this comorbidity should be targeted for intensive prevention and treatment focused on both disorders. Future research is needed to identify the role of unknown factors and mediators that might clarify the nature of this association. (C) Copyright 2015 Physicians Postgraduate Press, Inc.
C1 [Bartoli, Francesco; Crocamo, Cristina; Alamia, Alberto; Amidani, Francesca; Paggi, Elisabetta; Pini, Elena; Clerici, Massimo] Univ Milano Bicocca, Dept Surg & Translat Med, Milan, Italy.
   [Carra, Giuseppe] UCL, Fac Brain Sci, Div Psychiat, London, England.
C3 University of Milano-Bicocca; University of London; University College
   London
RP Clerici, M (corresponding author), Univ Milano Bicocca, Dept Surg & Interdisciplinary Med, Via Cadore 48, I-20900 Monza, MB, Italy.
EM massimo.clerici@unimib.it
RI Crocamo, Cristina/I-4355-2019; Alamia, Alberto/MFK-2198-2025; Clerici,
   Massimo/U-3074-2019; Pini, Elena/G-3829-2017; Bartoli,
   Francesco/K-5755-2016; Crocamo, Cristina/B-5404-2014; Carra,
   Giuseppe/C-6091-2012
OI Bartoli, Francesco/0000-0003-2612-4119; Crocamo,
   Cristina/0000-0002-2979-2107; Clerici, Massimo/0000-0001-8769-6474;
   Carra, Giuseppe/0000-0002-6877-6169
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NR 81
TC 57
Z9 61
U1 0
U2 18
PU PHYSICIANS POSTGRADUATE PRESS
PI MEMPHIS
PA P O BOX 752870, MEMPHIS, TN 38175-2870 USA
SN 0160-6689
EI 1555-2101
J9 J CLIN PSYCHIAT
JI J. Clin. Psychiatry
PD OCT
PY 2015
VL 76
IS 10
BP E1253
EP +
DI 10.4088/JCP.14r09199
PG 13
WC Psychology, Clinical; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA DB2OC
UT WOS:000368347900001
PM 26528647
DA 2025-06-11
ER

PT J
AU Yurtdas, G
   Akbulut, G
   Baran, M
   Yilmaz, C
AF Yurtdas, Gamze
   Akbulut, Gamze
   Baran, Masallah
   Yilmaz, Canan
TI The effects of Mediterranean diet on hepatic steatosis, oxidative
   stress, and inflammation in adolescents with non-alcoholic fatty liver
   disease: A randomized controlled trial
SO PEDIATRIC OBESITY
LA English
DT Article
DE adolescent; inflammation; insulin resistance; Mediterranean diet;
   non-alcoholic fatty liver disease; oxidative stress
ID WEIGHT-LOSS; METABOLIC SYNDROME; EXPERT COMMITTEE; DIAGNOSIS; CHILDREN;
   SUPPLEMENTATION; RECOMMENDATIONS; SEVERITY; PATTERN; OBESITY
AB Background Non-alcoholic fatty liver disease (NAFLD) has become the most common liver disease in children and adolescents. The optimal dietary strategy to improve hepatic stetatosis and reduce oxidative stress and inflammation in adolescents is unknown. Objective This study was conducted to evaluate the effect of Mediterranean diet (MD) versus low-fat diet (LFD) on hepatic steatosis, inflammation, and oxidative stress in adolescents with obesity and NAFLD. Methods Adolescents diagnosed with NAFLD between the ages of 11-18 years were randomized to either a MD or conventional LFD (control diet) for 12 weeks. Dietary status, anthropometry, body composition, and biochemical parameters were evaluated. Hepatic steatosis was determined by ultrasonography. Results A total of 44 participants completed the study. At the end of the study, severity of hepatic steatosis, serum transaminase levels, and insulin resistance decreased significantly in both groups with no significant differences between groups except for aspartate aminotransferase (AST). The amount of decrease in AST levels in the MD group was greater than the LFD group (p < 0.05). In the MD group, serum total antioxidant capacity, paraoxanase-1, and glutathione peroxidase levels increased (p < 0.05); it did not change in the LFD group compared to baseline (p > 0.05). C-Reactive Protein (CRP) levels decreased only in the MD group (p = 0.008), interleukine-6 decreased only in the LFD group (p = 0.031). Conclusion Consumption of MD and LFD for 12 weeks in adolescents with obesity and NAFLD reduced BMI, fat mass, hepatic steatosis, and insulin resistance, improved high transaminase levels, and had positive effects on inflammation and oxidative stress. Registered under Identifier no. NCT04845373.
C1 [Yurtdas, Gamze] Izmir Katip Celebi Univ, Fac Hlth Sci, Dept Nutr & Dietet, Izmir, Turkey.
   [Akbulut, Gamze] Gazi Univ, Fac Hlth Sci, Dept Nutr & Dietet, Ankara, Turkey.
   [Baran, Masallah] Izmir Katip Celebi Univ, Fac Med, Dept Pediat Gastroenterol Hepatol & Nutr, Izmir, Turkey.
   [Yilmaz, Canan] Gazi Univ, Fac Med, Dept Biochem, Ankara, Turkey.
C3 Izmir Katip Celebi University; Gazi University; Izmir Katip Celebi
   University; Gazi University
RP Yurtdas, G (corresponding author), Izmir Katip Celebi Univ, Fac Hlth Sci, Dept Nutr & Dietet, Cigli Ana Yerleskesi Merkezi Ofisler, TR-35620 Cigli Izmir, Turkey.
EM gmzyurtdas@hotmail.com
RI Baran, Masallah/ACJ-1208-2022; Yurtdaş, Gamze/ACA-1910-2022; Yılmaz,
   Canan/AAT-7788-2020
OI Baran, Masallah/0000-0003-3827-2039; YILMAZ, CANAN/0000-0002-6799-6522;
   Yurtdas Depboylu, Gamze/0000-0001-5410-7231
FU Gazi University Scientific Research Projects (BAP) unit [47/2020-05]
FX This study was supported by Gazi University Scientific Research Projects
   (BAP) unit (project code: 47/2020-05).
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NR 48
TC 38
Z9 40
U1 3
U2 23
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2047-6302
EI 2047-6310
J9 PEDIATR OBES
JI Pediatr. Obes.
PD APR
PY 2022
VL 17
IS 4
AR e12872
DI 10.1111/ijpo.12872
EA DEC 2021
PG 12
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA ZS1CG
UT WOS:000728740900001
PM 34881510
DA 2025-06-11
ER

PT J
AU Meroño, T
   Dauteuille, C
   Tetzlaff, W
   Martín, M
   Botta, E
   Lhomme, M
   Saez, MS
   Sorroche, P
   Boero, L
   Arbelbide, J
   Chapman, MJ
   Kontush, A
   Brites, F
AF Merono, Tomas
   Dauteuille, Carolane
   Tetzlaff, Walter
   Martin, Maximiliano
   Botta, Eliana
   Lhomme, Marie
   Soledad Saez, Maria
   Sorroche, Patricia
   Boero, Laura
   Arbelbide, Jorge
   Chapman, M. John
   Kontush, Anatol
   Brites, Fernando
TI Oxidative stress, HDL functionality and effects. of intravenous iron
   administration in women with iron deficiency anemia
SO CLINICAL NUTRITION
LA English
DT Article
DE Iron deficiency anemia; HDL; Oxidative stress; Iron; Lipoproteins;
   Paraoxonase
ID FOAM CELL-FORMATION; CHOLESTEROL EFFLUX; CARDIOVASCULAR-DISEASE;
   METABOLIC SYNDROME; RISK-FACTOR; PARTICLES; ATHEROSCLEROSIS;
   HEMODIALYSIS; EXPRESSION; SUCROSE
AB Background and aims: Iron deficiency anemia (IDA) affects around 20-30% of adults worldwide. An association between IDA and cardiovascular disease (CVD) has been reported. Oxidative stress, inflammation and low concentration of high-density lipoproteins (HDL) were implicated on endothelial dysfunction and CVD in IDA. We studied the effects of iron deficiency and of an intravenous iron administration on oxidative stress and HDL characteristics in IDA women.
   Methods: Two studies in IDA women are presented: a case-control study, including 18 patients and 18 age-matched healthy women, and a follow-up study 72hr after the administration of intravenous iron (n = 16). Lipids, malondialdehyde, cholesteryl ester transfer protein (CETP), paraoxonase-1 (PON-1) and HDL chemical composition and functionality (cholesterol efflux and antioxidative activity) were measured. Cell cholesterol efflux from iron-deficient macrophages to a reference HDL was also evaluated.
   Results: IDA patients showed higher triglycerides and CETP activity and lower HDL-C than controls (all p < 0.001). HDL particles from IDA patients showed higher triglyceride content (+30%,p < 0.05) and lower antioxidative capacity (-23%,p < 0.05). Although HDL-mediated cholesterol efflux was similar between the patients and controls, iron deficiency provoked a significant reduction in macrophage cholesterol efflux (-25%,p < 0.05). Arylesterase activity of PON-1 was significantly lower in IDA patients than controls (-16%,p < 0.05). The intravenous administration of iron was associated with a decrease in malondialdehyde levels and an increase in arylesterase activity of PON-1 (-22% and +18%, respectively, p < 0.05).
   Conclusion: IDA is associated with oxidative stress and functionally deficient HDL particles. It remains to be determined if such alterations suffice to impair endothelial function in IDA. (C) 2016 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.
C1 [Merono, Tomas; Tetzlaff, Walter; Martin, Maximiliano; Botta, Eliana; Boero, Laura; Brites, Fernando] Univ Buenos Aires, CONICET, Lab Lipids & Atherosclerosis, Sch Pharm & Biochem,INFIBIOC, Junin 956, RA-1113 Buenos Aires, DF, Argentina.
   [Dauteuille, Carolane; Lhomme, Marie; Chapman, M. John; Kontush, Anatol] Univ Pierre & Marie Curie Paris 6, Grp Hosp Pitie Salpetriere, AP HP, Natl Inst Hlth & Med Res INSERM,UMR ICAN 1166, F-75013 Paris, France.
   [Soledad Saez, Maria; Sorroche, Patricia] Italian Hosp Buenos Aires, Cent Lab, Buenos Aires, DF, Argentina.
   [Arbelbide, Jorge] Italian Hosp Buenos Aires, Hematol Div, Buenos Aires, DF, Argentina.
C3 University of Buenos Aires; Consejo Nacional de Investigaciones
   Cientificas y Tecnicas (CONICET); Sorbonne Universite; Assistance
   Publique Hopitaux Paris (APHP); Hopital Universitaire Pitie-Salpetriere
   - APHP; Institut National de la Sante et de la Recherche Medicale
   (Inserm); Hospital Italiano de Buenos Aires; University of Buenos Aires;
   University of Buenos Aires Hospital; University of Buenos Aires;
   University of Buenos Aires Hospital; Hospital Italiano de Buenos Aires
RP Meroño, T (corresponding author), Univ Buenos Aires, CONICET, Lab Lipids & Atherosclerosis, Sch Pharm & Biochem,INFIBIOC, Junin 956, RA-1113 Buenos Aires, DF, Argentina.
EM tomasmero@yahoo.com.ar
RI chapman, john/Y-2742-2019; Kontush, Anatol/J-2198-2016; Evelson,
   Pablo/J-1245-2014; Merono, Tomas/T-4060-2017
OI Kontush, Anatol/0000-0002-9008-7335; Merono, Tomas/0000-0002-2673-3494;
   LHOMME, MARIE/0000-0002-6335-4506; Martin,
   Maximiliano/0000-0002-8555-9174
FU University of Buenos Aires [UBACyT CB23]; Consejo Nacional de
   Investigaciones Cientificas y Tecnicas [CONICET PIP 516]; Agencia
   Nacional de Promocion Cientifica y Tecnologica [ANPCyT 0418]; Comision
   Salud Investiga, Ministerio de Salud de la Republica Argentina [NRU
   1242]; CONICET; National Institute for Health and Medical Research
   (INSERM, Paris, France); ANR (CARINA Project); CODDIM Ile-de-France;
   University of Pierre and Marie Curie (UPMC)
FX The authors acknowledge the support of grants from the University of
   Buenos Aires (UBACyT CB23), the Consejo Nacional de Investigaciones
   Cientificas y Tecnicas (CONICET PIP 516) and the Agencia Nacional de
   Promocion Cientifica y Tecnologica (ANPCyT 0418). TM has received
   additional support from an scholarship granted by the Comision Salud
   Investiga, Ministerio de Salud de la Republica Argentina (NRU 1242). We
   gratefully acknowledge further support from a collaborative grant
   between CONICET and National Institute for Health and Medical Research
   (INSERM, Paris, France), as well as, the support from the ANR (CARINA
   Project), CODDIM Ile-de-France and University of Pierre and Marie Curie
   (UPMC).
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NR 31
TC 18
Z9 21
U1 0
U2 12
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0261-5614
EI 1532-1983
J9 CLIN NUTR
JI Clin. Nutr.
PD APR
PY 2017
VL 36
IS 2
BP 552
EP 558
DI 10.1016/j.clnu.2016.02.003
PG 7
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA ES5ZG
UT WOS:000399624700029
PM 26926576
OA Green Published
DA 2025-06-11
ER

PT J
AU Bruno, RM
   Ghiadoni, L
AF Bruno, Rosa Maria
   Ghiadoni, Lorenzo
TI Polyphenols, Antioxidants and the Sympathetic Nervous System
SO CURRENT PHARMACEUTICAL DESIGN
LA English
DT Review
DE Polyphenols; antioxidants; oxidative stress; sympathetic nervous system;
   microneurography; blood pressure
ID SPONTANEOUSLY HYPERTENSIVE-RATS; OBSTRUCTIVE SLEEP-APNEA;
   ENDOTHELIUM-DEPENDENT VASODILATION; HEART-RATE-VARIABILITY; NITRIC-OXIDE
   SYNTHASE; CHRONIC-RENAL-FAILURE; OXIDATIVE STRESS; BLOOD-PRESSURE;
   CARDIOVASCULAR-DISEASE; VITAMIN-C
AB Background: A high dietary intake of polyphenols has been associated with a reduced cardiovascular mortality, due to their antioxidant properties. However, growing evidence suggests that counteracting oxidative stress in cardiovascular disease might also reduce sympathetic nervous system overactivity.
   Methods: This article reviews the most commonly used techniques to measure sympathetic activity in humans; the role of sympathetic activation in the pathophysiology of cardiovascular diseases; current evidence demonstrating that oxidative stress is involved in the regulation of sympathetic activity and how antioxidants and polyphenols might counteract sympathetic overactivity, particularly focusing on preliminary data from human studies.
   Results: The main mechanisms by which polyphenols are cardioprotective are related to the improvement of vascular function and their anti-atherogenic effect. Furthermore, a blood pressure-lowering effect was consistently demonstrated in randomized controlled trials in humans, when the effect of flavonoid-rich foods, such as tea and chocolate, was tested. More recent studies suggest that inhibition of sympathetic overactivity might be one of the mechanisms by which these substances exert their cardioprotective effects. Indeed, an increased adrenergic traffic to the vasculature is a major mechanism of disease in a number of cardiovascular and extra-cardiac diseases, including hypertension, obesity, metabolic syndrome and heart failure. A considerable body of evidence, mostly from experimental studies, support the hypothesis that reactive oxygen species might exert sympatho-excitatory effects both at the central and at the peripheral level. Accordingly, supplementation with antioxidants might reduce adrenergic overdrive to the vasculature and blunt cardiovascular reactivity to stress.
   Conclusions: While supplementation with "classical" antioxidants such as ROS-scavengers has many limitations, increasing the intake of polyphenol-rich foods seems to be a promising novel therapeutic strategy to reduce the deleterious effects of increased adrenergic tone, particularly in essential hypertension.
C1 [Bruno, Rosa Maria; Ghiadoni, Lorenzo] Univ Pisa, Dept Clin & Expt Med, Via Roma 67, I-56125 Pisa, Italy.
C3 University of Pisa
RP Ghiadoni, L (corresponding author), Univ Pisa, Dept Clin & Expt Med, Via Roma 67, I-56125 Pisa, Italy.
EM lorenzo.ghiadoni@med.unipi.it
RI Ghiadoni, Lorenzo/AAC-5176-2022; Bruno, Rosa Maria/C-3594-2015
OI Ghiadoni, Lorenzo/0000-0002-7399-2720; Bruno, Rosa
   Maria/0000-0002-6107-3356
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NR 130
TC 22
Z9 23
U1 1
U2 20
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1381-6128
EI 1873-4286
J9 CURR PHARM DESIGN
JI Curr. Pharm. Design
PY 2018
VL 24
IS 2
BP 130
EP 139
DI 10.2174/1381612823666171114170642
PG 10
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA GB5RZ
UT WOS:000429125100004
PM 29141540
DA 2025-06-11
ER

PT J
AU Nakagawa, Y
   Kishida, K
   Kihara, S
   Yoshida, R
   Funahashi, T
   Shimomura, I
AF Nakagawa, Yasuhiko
   Kishida, Ken
   Kihara, Shinji
   Yoshida, Ryoko
   Funahashi, Tohru
   Shimomura, Iichiro
TI Nocturnal Falls of Adiponectin Levels in Sleep Apnea with Abdominal
   Obesity and Impact of Hypoxia-Induced Dysregulated Adiponectin
   Production in Obese Murine Mesenteric Adipose Tissue
SO JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
LA English
DT Article
DE Nocturnal falls of adiponectin; Body fat distribution; Waist-hip ratio;
   Mesenteric fat tissues; Obstructive sleep apnea-hypopnea syndrome
ID VISCERAL FAT ACCUMULATION; HYPOPNEA SYNDROME; INSULIN-RESISTANCE;
   METABOLIC SYNDROME; OXIDATIVE STRESS; CARDIOVASCULAR RISK; LEPTIN;
   PLASMA; EXPRESSION
AB Aim: Obstructive sleep apnea-hypopnea syndrome (OSAS) is associated with atherosclerotic cardiovascular disease. We reported recently daytime hypoadiponectinemia and nocturnal falls in circulating adiponectin concentrations (Delta adiponectin) in OSAS patients, in part due to hypoxic stress. The present study investigated the association between Delta adiponectin and fat distribution in OSAS males, and the effect of hypoxic stress on adiponectin production in obese yellow-KKAy mice.
   Methods: The participants in this study were 43 Japanese males who visited the clinic and were newly diagnosed with OSAS. Venous blood samples were collected before sleep and after wakingup. We investigated the effect of hypoxia on adiponectin expression in mesenteric and subcutaneous fat tissues of obese yellow-KKAy mice. We measured adiponectin secretion into media under hypoxic conditions in an ex-vivo model of yellow-KKAy mice.
   Results: In OSAS males with a relatively higher body mass index (BMI), Delta adiponectin correlated inversely with the waist-hip ratio, but not with BMI, waist circumference or hip circumference. In obese yellow-KKAy mice, exposure to hypoxia for 2 days suppressed plasma adiponectin levels, with no apparent change in mesenteric and subcutaneous fat tissue adiponectin mRNA expression. In an ex-vivo study of obese yellow-KKAy mice, hypoxic stress reduced adiponectin in the supernatant of mesenteric fat tissues, but not subcutaneous fat tissues.
   Conclusions: These findings suggest that abdominal obesity, representing abundant mesenteric fat tissue susceptible to hypoxic stress, partly explains Delta adiponectin in OSAS patients, and that reduction of visceral fat accumulation may combat OSAS-related atherosclerotic cardiovascular diseases in abdominal obesity.
C1 [Nakagawa, Yasuhiko; Kishida, Ken; Kihara, Shinji; Funahashi, Tohru; Shimomura, Iichiro] Osaka Univ, Dept Metab Med, Grad Sch Med, Suita, Osaka 5650871, Japan.
   [Yoshida, Ryoko] Yoshida Suimin Kokyu Clin, Osaka, Japan.
C3 The University of Osaka
RP Kishida, K (corresponding author), Osaka Univ, Dept Metab Med, Grad Sch Med, 2-2 B-5 Yamada Oka, Suita, Osaka 5650871, Japan.
EM kkishida@imed2.med.osaka-u.ac.jp
RI Kihara, Shinji/AAW-2015-2021
FU  [21591177]
FX We are grateful to Mrs. Misato Nakano for help with apnomonitor scoring.
   We thank the staff of Yoshida Suimin-kokyu Clinic for the helpful
   technical assistance. We also thank all members of the Third Laboratory
   (Funahashi Adiposcience Laboratory) for helpful discussions on this
   project. This research was supported in part by a Grant-in-Aid for
   Scientific Research No. (C) 21591177 (to K. K.).
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NR 32
TC 30
Z9 33
U1 0
U2 3
PU JAPAN ATHEROSCLEROSIS SOC
PI TOKYO
PA NICHINAI-KAIKAN B1, 3-28-8 HONGO BUNKYO-KU, TOKYO, 113-0033, JAPAN
SN 1340-3478
EI 1880-3873
J9 J ATHEROSCLER THROMB
JI J. Atheroscler. Thromb.
PY 2011
VL 18
IS 3
BP 240
EP 247
DI 10.5551/jat.6593
PG 8
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 750FJ
UT WOS:000289530600009
PM 21139317
OA hybrid
DA 2025-06-11
ER

PT J
AU Moon, KM
   Lee, B
   Jeong, JW
   Kim, DH
   Park, YJ
   Kim, HR
   Park, JY
   Kim, MJ
   An, HJ
   Lee, EK
   Ha, YM
   Im, E
   Chun, P
   Ma, JY
   Cho, WK
   Moon, HR
   Chung, HY
AF Moon, Kyoung Mi
   Lee, Bonggi
   Jeong, Ji Won
   Kim, Dae Hyun
   Park, Yun Jung
   Kim, Hye Rim
   Park, Ji Young
   Kim, Min Jo
   An, Hye Jin
   Lee, Eun Kyeong
   Ha, Young Mi
   Im, Eunok
   Chun, Pusoon
   Ma, Jin Yeul
   Cho, Won-Kyung
   Moon, Hyung Ryong
   Chung, Hae Young
TI Thio-barbiturate-derived compounds are novel antioxidants to prevent
   LPS-induced inflammation in the liver
SO ONCOTARGET
LA English
DT Article
DE oxidative stress; antioxidant; compound 2d; compound 2l; inflammation
ID NF-KAPPA-B; HEPATIC MACROPHAGES; INACTIVATION; MECHANISMS; EXPRESSION;
   FIBROSIS; CANCER; ROLES; CELLS; PTEN
AB Liver inflammation is closely associated with metabolic syndrome. Oxidative stress plays a synergistic role in inflammation by activating nuclear factor kappa B (NF-kappa B) signaling in the liver. Therefore, substantial efforts have been made to develop compounds that inhibit the generation of oxidative stress and activation of NF-kappa B. We synthesized twenty-six novel 5-(substituted benzyl)-2-oxo-and 5-(substituted benzyl)-2-thioxo-dihydropyrimidine-4,6(1H, 5H)-dione derivatives for the development of potential antioxidants and examined their biological activities in vitro and in vivo. Thio-barbiturate-derived compounds 5-[4-hydroxy-3methoxybenzy]- 2-thioxodihydropyrimidine-4,6[1H, 5H]-dione (2d) and 5-[4-hydroxy3,5- methoxybenzy]-2-thioxodihydropyrimidine-4,6[1H, 5H]-dione (2l) had the strongest inhibitory effect on reactive oxygen species and peroxynitrite generation in vitro. Furthermore, oral administration of compounds 2d and 2l in mice notably suppressed lipopolysaccharide (LPS)-induced oxidative stress and NF-kappa B activation in the liver. Because macrophages play an essential role in liver inflammation, we investigated the effects of these compounds on inflammatory signaling in LPS-induced RAW264.7 macrophages. LPS-induced NF-kappa B activation and protein expression of cyclooxygenase 2 and inducible nitric oxide synthase were inhibited by pretreatment of these compounds in macrophages. In parallel with this finding, the phosphatase and tensin homolog deleted on chromosome 10 (PTEN) and AKT signalings, which are upstream activators of p65, were decreased by these compounds in macrophages. Our study suggests that compounds 2d and 2l inhibit oxidative stress and NF-kappa Bmediated inflammation, at least partially, through suppressing PTEN/AKT signaling. Therefore, these compounds may be useful as therapeutic agents for the amelioration of inflammatory diseases.
C1 [Moon, Kyoung Mi; Lee, Bonggi; Jeong, Ji Won; Kim, Dae Hyun; Kim, Min Jo; An, Hye Jin; Lee, Eun Kyeong; Im, Eunok; Chung, Hae Young] Pusan Natl Univ, Coll Pharm, Mol Inflammat Res Ctr Aging Intervent, Busan, South Korea.
   [Park, Yun Jung; Kim, Hye Rim; Park, Ji Young; Moon, Hyung Ryong] Pusan Natl Univ, Coll Pharm, Lab Med Chem, Busan, South Korea.
   [Ha, Young Mi] Dong A Univ, Dept Chem, Busan, South Korea.
   [Chun, Pusoon] Inje Univ, Coll Pharm, Inje Ro, Gyeongnam, South Korea.
   [Moon, Kyoung Mi; Lee, Bonggi; Ma, Jin Yeul; Cho, Won-Kyung] Korea Inst Oriental Med, Korean Med Applicat Ctr, Daegu, South Korea.
C3 Pusan National University; Pusan National University; Dong A University;
   Inje University; Korea Institute of Oriental Medicine (KIOM)
RP Chung, HY (corresponding author), Pusan Natl Univ, Coll Pharm, Mol Inflammat Res Ctr Aging Intervent, Busan, South Korea.; Moon, HR (corresponding author), Pusan Natl Univ, Coll Pharm, Lab Med Chem, Busan, South Korea.
EM mhr108@pusan.ac.kr; hyjung@pusan.ac.kr
RI Jung, SeungHyun/HTS-1049-2023
FU National Research Foundation of Korea (NRF) grant - Korea government
   (MSIP) [2009-0083538]; Korea Institute of Oriental Medicine, Ministry of
   Education, Science and Technology (MEST), Republic of Korea [K17281]
FX This work was supported by the National Research Foundation of Korea
   (NRF) grant funded by the Korea government (MSIP) (No. 2009-0083538).
   This work was also supported by Grant K17281 from the Korea Institute of
   Oriental Medicine, Ministry of Education, Science and Technology (MEST),
   Republic of Korea. We also thank the Korea Aging Tissue Bank for
   providing research materials.
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NR 25
TC 10
Z9 10
U1 0
U2 3
PU IMPACT JOURNALS LLC
PI ORCHARD PARK
PA 6666 E QUAKER ST, STE 1, ORCHARD PARK, NY 14127 USA
EI 1949-2553
J9 ONCOTARGET
JI Oncotarget
PD OCT 31
PY 2017
VL 8
IS 53
BP 91662
EP 91673
DI 10.18632/oncotarget.21714
PG 12
WC Oncology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Cell Biology
GA FL4CX
UT WOS:000414175500099
PM 29207675
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Bankoglu, EE
   Tschopp, O
   Schmitt, J
   Burkard, P
   Jahn, D
   Geier, A
   Stopper, H
AF Bankoglu, Ezgi Eyluel
   Tschopp, Oliver
   Schmitt, Johannes
   Burkard, Philipp
   Jahn, Daniel
   Geier, Andreas
   Stopper, Helga
TI Role of PTEN in Oxidative Stress and DNA Damage in the Liver of
   Whole-Body Pten Haplodeficient Mice
SO PLOS ONE
LA English
DT Article
ID HIGH-FAT DIET; INSULIN-RESISTANCE; METABOLIC SYNDROME; HEME OXYGENASE-1;
   SKELETAL-MUSCLE; KIDNEY-CELLS; LIFE-STYLE; OBESITY; GROWTH; CANCER
AB Type 2 diabetes (T2DM) and obesity are frequently associated with non-alcoholic fatty liver disease (NAFLD) and with an elevated cancer incidence. The molecular mechanisms of carcinogenesis in this context are only partially understood. High blood insulin levels are typical in early T2DM and excessive insulin can cause elevated reactive oxygen species (ROS) production and genomic instability. ROS are important for various cellular functions in signaling and host defense. However, elevated ROS formation is thought to be involved in cancer induction. In the molecular events from insulin receptor binding to genomic damage, some signaling steps have been identified, pointing at the PI3K/AKT pathway. For further elucidation Phosphatase and Tensin homolog (Pten), a tumour suppressor phosphatase that plays a role in insulin signaling by negative regulation of PI3K/AKT and its downstream targets, was investigated here. Dihydroethidium (DHE) staining was used to detect ROS formation in immortalized human hepatocytes. Comet assay and micronucleus test were performed to investigate genomic damage in vitro. In liver samples, DHE staining and western blot detection of HSP70 and HO-1 were performed to evaluate oxidative stress response. DNA double strand breaks (DSBs) were detected by immunohistostaining. Inhibition of PTEN with the pharmacologic inhibitor VO-OHpic resulted in increased ROS production and genomic damage in a liver cell line. Knockdown of Pten in a mouse model yielded increased oxidative stress levels, detected by ROS levels and expression of the two stress-proteins HSP70 and HO-1 and elevated genomic damage in the liver, which was significant in mice fed with a high fat diet. We conclude that PTEN is involved in oxidative stress and genomic damage induction in vitro and that this may also explain the in vivo observations. This further supports the hypothesis that the PI3K/AKT pathway is responsible for damaging effects of high levels of insulin.
C1 [Bankoglu, Ezgi Eyluel; Burkard, Philipp; Stopper, Helga] Univ Wurzburg, Inst Pharmacol & Toxicol, Wurzburg, Germany.
   [Tschopp, Oliver; Geier, Andreas] Univ Zurich Hosp, Clin Endocrinol & Diabetol, Zurich, Switzerland.
   [Schmitt, Johannes; Jahn, Daniel; Geier, Andreas] Univ Hosp Wuerzburg, Dept Med 2, Div Hepatol, Wurzburg, Germany.
C3 University of Wurzburg; University of Zurich; University Zurich
   Hospital; University of Wurzburg
RP Stopper, H (corresponding author), Univ Wurzburg, Inst Pharmacol & Toxicol, Wurzburg, Germany.
EM stopper@toxi.uni-wuerzburg.de
RI Tschopp, Oliver/H-7545-2018; Bankoglu, Ezgi Eyluel/ABA-2543-2021
OI Bankoglu, Ezgi Eylul/0000-0001-7488-6228; Tschopp,
   Oliver/0000-0002-7733-7934; Burkard, Philipp/0000-0001-9748-7967
FU European Foundation for the Study of Diabetes in the frame of the
   "Research Program in Diabetes and Cancer"; Open Access Publication Fund
   of the University of Wuerzburg
FX This work was supported by the European Foundation for the Study of
   Diabetes in the frame of the "Research Program in Diabetes and Cancer"
   to AG and OT. This publication was supported by the Open Access
   Publication Fund of the University of Wuerzburg.
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NR 42
TC 27
Z9 28
U1 0
U2 7
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD NOV 28
PY 2016
VL 11
IS 11
AR e0166956
DI 10.1371/journal.pone.0166956
PG 20
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA EE3FE
UT WOS:000389472400062
PM 27893783
OA Green Submitted, gold, Green Published
DA 2025-06-11
ER

PT J
AU Hernández-Guerrero, C
   Romo-Palafox, I
   Díaz-Gutiérrez, MC
   Iturbe-García, M
   Texcahua-Salazar, A
   Pérez-Lizaur, AB
AF Hernandez-Guerrero, Cesar
   Romo-Palafox, Ines
   Carmen Diaz-Gutierrez, Mary
   Iturbe-Garcia, Mariana
   Texcahua-Salazar, Alejandra
   Bertha Perez-Lizaur, Ana
TI PREVALENCIA DEL POLIMORFISMO C677T DE LA METILENTETRAIDDROFOLATO
   REDUCTASA, CONSUMO DE LAS VITAMINAS B6, B9, B12 Y DETERMINACION DE
   HIDROPEROXIDOS LIPIDICOS EN POBLACION MEXICANA OBESA Y CON PESO NORMAL
SO NUTRICION HOSPITALARIA
LA English
DT Article
DE Obesity; MTHFR-C677T polymorphism; Vitamins; Lipid hydroperoxide;
   Oxidative stress
ID HOMOCYSTEINE LEVELS; METABOLIC SYNDROME; OXIDANT STRESS; SERUM FOLATE;
   BODY-MASS; POLYMORPHISM; GENE; OVERWEIGHT/OBESITY; ADULTS; WOMEN
AB Introduction: Oxidative stress is a key factor in the development of the principal comorbidities of obesity. Methylenetetrahydrofolate reductase enzyme (MTHFR) participates in the metabolism of folate with the action of vitamins B6 and B12. The gene of MTHFR may present a single nucleotide polymorphism (SNP) at position 677 (C677T), which can promote homocysteinemia associated to the production of free radicals.
   Objective: To determine the frequency of SNP C677T of the MTHFR, evaluate the consumption of vitamins B6, B9, B12 and determine the concentration of plasma lipid hydroperoxides (LOOH) in obese and control groups.
   Methods: 128 Mexican mestizo according to their body mass index were classified as normal weight (Nw; n = 75) and obesity (ObeI-III; n = 53). Identification of SNP C677T of MTHFR was performed by PCR-RFLP technic. The consumption of vitamins B6, B9 and B12 was assessed by a validate survey. LOOH was determined as an indicator of peripheral oxidative stress.
   Results: There was no statistical difference in the frequency of the C677T polymorphism between the TT homozygous genotype in Nw (0.19) and ObeI-III (0.25). The frequency of T allele in Nw was 0.45 and 0.51 in ObI-III group. There were no statistical differences in the consumption of vitamins B6, B9 and B12 between Nw and ObI-III groups. The LOOH showed statistical difference (p < 0.05) between Nw and ObI-III group.
   Discussion: Oxidative stress is present in all grades of obesity although there were no differences in the vitamin consumption and the SNP C677T between Nw and ObeI III groups.
C1 [Hernandez-Guerrero, Cesar; Carmen Diaz-Gutierrez, Mary; Bertha Perez-Lizaur, Ana] Univ Iberoamer Ciudad Mexico, Dept Salud, Mexico City 01219, DF, Mexico.
   [Romo-Palafox, Ines; Iturbe-Garcia, Mariana; Texcahua-Salazar, Alejandra] Univ Iberoamer Ciudad Mexico, Mexico City 01219, DF, Mexico.
C3 Universidad Iberoamericana Ciudad de Mexico; Universidad Iberoamericana
   Ciudad de Mexico
RP Hernández-Guerrero, C (corresponding author), Univ Iberoamer Ciudad Mexico, Dept Salud, Prolongac Paseo Reforma 880, Mexico City 01219, DF, Mexico.
EM cesar.hernandez@uia.mx
FU Universidad Iberoamericana Ciudad de Mexico who through the Research
   Direction
FX To the Universidad Iberoamericana Ciudad de Mexico who through the
   Research Direction funded the project at the "5<SUP>a</SUP> Convocatoria
   Para Financiamiento de Proyectos de Investigacion". To the team of the
   Nutrition Clinic and Laboratory of Research of the Health Department of
   the University, by their enthusiastic participation. To all the
   participants included in the study for their valuable collaboration.
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NR 30
TC 9
Z9 10
U1 0
U2 12
PU ARAN EDICIONES, S L
PI MADRID
PA C/ CASTELLO, 128, 1O, MADRID, 28006, SPAIN
SN 0212-1611
EI 1699-5198
J9 NUTR HOSP
JI Nutr. Hosp.
PD NOV-DEC
PY 2013
VL 28
IS 6
BP 2142
EP 2150
DI 10.3305/nh.2013.28.6.6902
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 304NC
UT WOS:000330752600046
PM 24506394
DA 2025-06-11
ER

PT J
AU Taguchi, K
   Okada, A
   Yasui, T
   Kobayashi, T
   Ando, R
   Tozawa, K
   Kohri, K
AF Taguchi, Kazumi
   Okada, Atsushi
   Yasui, Takahiro
   Kobayashi, Takahiro
   Ando, Ryosuke
   Tozawa, Keiichi
   Kohri, Kenjiro
TI Pioglitazone, a Peroxisome Proliferator Activated Receptor γ Agonist,
   Decreases Renal Crystal Deposition, Oxidative Stress and Inflammation in
   Hyperoxaluric Rats
SO JOURNAL OF UROLOGY
LA English
DT Article
DE kidney; kidney calculi; inflammation; pioglitazone; oxidative stress
ID CALCIUM-OXALATE NEPHROLITHIASIS; PPAR-GAMMA; EPITHELIAL-CELLS;
   KIDNEY-STONES; INJURY; ROSIGLITAZONE; MACROPHAGES; EXPRESSION;
   INDUCTION; APOPTOSIS
AB Purpose: Kidney stone disease has characteristics similar to those of metabolic syndrome, including inflammation and oxidative stress. The peroxisome proliferator activated receptor gamma agonist pioglitazone (AK Scientific, Union, California) is used to treat type 2 diabetes mellitus with an adjunctive effect that improves glycemic control and has anti-inflammatory and antioxidative effects. We investigated the preventive effects of pioglitazone for stone formation in a hyperoxaluric rat model.
   Materials and Methods: We divided Sprague-Dawley (R) rats into a control group, a 1% ethylene glycol group and a 1% ethylene glycol plus 10 mg/kg pioglitazone group. Blood and 24-hour urine samples, and kidney sections were collected on days 7, 14 and 28. We examined crystal formation using Pizzolato staining and polarized light optical microscopy. We also evaluated cell injury, apoptosis and oxidative stress with N-acetyl-beta-glucosaminidase, 8- hydroxydeoxyguanosine and TUNEL assay. Expression of crystal and inflammation related genes was examined by immunohistochemistry and quantitative reverse transcriptase-polymerase chain reaction.
   Results: Kidney crystal formation was significantly less in the ethylene glycol plus pioglitazone group than in the ethylene glycol group. Cell injury, apoptosis and oxidative stress markedly decreased after pioglitazone administration. Expression of osteopontin and ED1 for proinflammatory macrophages was lower in the ethylene glycol plus pioglitazone group than in the ethylene glycol group while that of ED2 for anti-inflammatory macrophages was the same in the 2 groups. Linear regression analysis showed a significant change in the correlation coefficient with pioglitazone treatment between Spp1 and Sod1 expression, and the amount of crystals.
   Conclusions: Pioglitazone suppressed kidney crystal formation through renal tubular cell protection, and antioxidative and anti-inflammatory effects in hyperoxaluric rats.
C1 [Okada, Atsushi] Nagoya City Univ, Dept Nephrol, Grad Sch Med Sci, Mizuho Ku, Nagoya, Aichi 4678601, Japan.
C3 Nagoya City University
RP Okada, A (corresponding author), Nagoya City Univ, Dept Nephrol, Grad Sch Med Sci, Mizuho Ku, 1 Kawasumi,Mizuho Cho, Nagoya, Aichi 4678601, Japan.
EM a-okada@med.nagoya-cu.ac.jp
RI YASUI, Takahiro/E-6401-2018; Taguchi, Kazumi/AFU-4486-2022
OI Okada, Atsushi/0000-0003-2080-3794; Taguchi, Kazumi/0000-0002-3092-5114;
   Yasui, Takahiro/0000-0003-2197-2477
FU Grants-in-Aid for Scientific Research [24659716, 23249074, 23592375]
   Funding Source: KAKEN
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NR 28
TC 36
Z9 42
U1 1
U2 7
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0022-5347
J9 J UROLOGY
JI J. Urol.
PD SEP
PY 2012
VL 188
IS 3
BP 1002
EP 1011
DI 10.1016/j.juro.2012.04.103
PG 10
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 989HP
UT WOS:000307551200111
PM 22819112
DA 2025-06-11
ER

PT J
AU Gjerde, PB
   Simonsen, CE
   Lagerberg, TV
   Steen, NE
   Andreassen, OA
   Steen, VM
   Melle, I
AF Gjerde, Priyanthi B.
   Simonsen, Carmen E.
   Lagerberg, Trine, V
   Steen, Nils Eiel
   Andreassen, Ole A.
   Steen, Vidar M.
   Melle, Ingrid
TI Sex-Specific Effect of Serum Lipids and Body Mass Index on Psychotic
   Symptoms, a Cross-Sectional Study of First-Episode Psychosis Patients
SO FRONTIERS IN PSYCHIATRY
LA English
DT Article
DE schizophrenia; psychosis; gender; serum lipids; BMI; clinical outcome
ID NEGATIVE SYNDROME SCALE; GENDER-DIFFERENCES; SCHIZOPHRENIA-PATIENTS;
   WEIGHT-GAIN; DEPRESSIVE SYMPTOMS; DRUG-NAIVE; 2ND-GENERATION
   ANTIPSYCHOTICS; METABOLIC DYSREGULATION; CARDIOVASCULAR-DISEASE;
   CARDIOMETABOLIC RISK
AB Background: Schizophrenia is a disorder with considerable heterogeneity in course and outcomes, which is in part related to the patients' sex. Studies report a link between serum lipids, body mass index (BMI), and therapeutic response. However, the role of sex in these relationships is poorly understood. In a cross-sectional sample of first-episode psychosis (FEP) patients, we investigated if the relationship between serum lipid levels (total cholesterol, HDL-C, LDL-C, and triglycerides), BMI, and symptoms differs between the sexes.
   Methods: We included 435 FEP patients (males: N = 283, 65%) from the ongoing Thematically Organized Psychosis (TOP) study. Data on clinical status, antipsychotics, lifestyle, serum lipid levels, and BMI were obtained. The Positive and Negative Syndrome Scale (PANSS) and the Calgary Depression Scale for Schizophrenia (CDSS) were used to assess psychotic and depressive symptoms. General linear models were employed to examine the relationship between metabolic variables and symptomatology.
   Results: We observed a female-specific association between serum HDL-C levels and negative symptoms (B = -2.24, p = 0.03) and between triglycerides levels (B = 1.48, p = 0.04) and BMI (B = 0.27, p = 0.001) with depressive symptoms. When controlling for BMI, only the association between serum HDL-C levels and negative symptoms remained significant. Moreover, the HDL-C and BMI associations remained significant after controlling for demography, lifestyle, and illness-related factors.
   Conclusion: We found a relationship between metabolic factors and psychiatric symptoms in FEP patients that was sex-dependent.
C1 [Gjerde, Priyanthi B.; Steen, Vidar M.] Univ Bergen, Norwegian Ctr Mental Disorders Res, Dept Clin Sci, Bergen, Norway.
   [Gjerde, Priyanthi B.; Steen, Vidar M.] Haukeland Hosp, Dept Med Genet, Dr Einar Martens Res Grp Biol Psychiat, Bergen, Norway.
   [Gjerde, Priyanthi B.] NORCE Norwegian Res Ctr, Res Unit Gen Practice, Bergen, Norway.
   [Simonsen, Carmen E.; Lagerberg, Trine, V; Steen, Nils Eiel; Andreassen, Ole A.; Melle, Ingrid] Oslo Univ Hosp, Norwegian Ctr Mental Disorders Res, Oslo, Norway.
   [Simonsen, Carmen E.; Steen, Nils Eiel; Andreassen, Ole A.; Melle, Ingrid] Univ Oslo, Inst Clin Med, Oslo, Norway.
C3 University of Bergen; University of Bergen; Haukeland University
   Hospital; Norwegian Research Centre (NORCE); University of Oslo;
   University of Oslo
RP Gjerde, PB (corresponding author), Univ Bergen, Norwegian Ctr Mental Disorders Res, Dept Clin Sci, Bergen, Norway.; Gjerde, PB (corresponding author), Haukeland Hosp, Dept Med Genet, Dr Einar Martens Res Grp Biol Psychiat, Bergen, Norway.; Gjerde, PB (corresponding author), NORCE Norwegian Res Ctr, Res Unit Gen Practice, Bergen, Norway.
EM prig@norceresearch.no
RI Simonsen, Carmen/LFV-3057-2024; Steen, Nils Eiel/GRO-6284-2022; Melle,
   Ingrid/B-4858-2011; Lagerberg, Trine/L-1766-2017; Andreassen,
   Ole/AAY-7531-2020
FU Research Council of Norway; Centre of Excellence funding scheme
   [SKGJ-MED-008]; Centre of Stiftelsen Kristian Gerhard Jebsen
FX This study was supported by grants from the Research Council of Norway
   to NORMENT CoE (Grant No. 223273/F50, under the Centres of Excellence
   funding scheme) and Stiftelsen Kristian Gerhard Jebsen (SKGJ-MED-008).
   The funding bodies had no role in the analyses or writing of the
   manuscript or the decision to submit this work for publication.
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NR 86
TC 5
Z9 5
U1 0
U2 5
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-0640
J9 FRONT PSYCHIATRY
JI Front. Psychiatry
PD OCT 21
PY 2021
VL 12
AR 723158
DI 10.3389/fpsyt.2021.723158
PG 10
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA WU6DX
UT WOS:000716635200001
PM 34744818
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Duggan, C
   Tapsoba, JD
   Wang, CY
   Campbell, KL
   Foster-Schubert, K
   Gross, MD
   McTiernan, A
AF Duggan, Catherine
   Tapsoba, Jean de Dieu
   Wang, Ching-Yun
   Campbell, Kristin L.
   Foster-Schubert, Karen
   Gross, Myron D.
   McTiernan, Anne
TI Dietary Weight Loss, Exercise, and Oxidative Stress in Postmenopausal
   Women: A Randomized Controlled Trial
SO CANCER PREVENTION RESEARCH
LA English
DT Article
ID LOW-DENSITY-LIPOPROTEIN; BREAST-CANCER RISK; METABOLIC SYNDROME; URINARY
   ISOPROSTANE; PHYSICAL-ACTIVITY; INFLAMMATION; OBESITY; BIOMARKERS;
   MECHANISMS; PRODUCTS
AB Oxidative stress, a potential mechanism linking obesity and cancer, results from an imbalance between activation/inactivation of reactive oxygen species, byproducts of cellular metabolism. In a randomized controlled trial, we investigated effects of diet and/or exercise on biomarkers of oxidative stress. A total of 439 overweight/obese [body mass index (BMI) > 25 kg/m(2)] postmenopausal women, ages 50 of 75 years, were randomized to 12 months of (i) reduced-calorie weight loss diet ("diet"; n = 118); (ii) moderate-to-vigorous intensity aerobic exercise ("exercise"; n = 117); (iii) combined diet and exercise intervention ("diet + exercise"; n = 117); or (iv) control (n = 87). Outcomes were circulating markers of oxidative stress, including fluorescent oxidation products (FOP), F-2-isoprostanes, and oxidized low-density lipoprotein (LDL). On average, participants were 57.9 years, with a BMI of 30.9 kg/m(2). F-2-isprostanes were significantly reduced in the diet (-22.7%, P < 0.0002) and diet + exercise (-23.5%, P < 0.0001) arms versus controls (-2.99%) and nonsignificantly reduced in the exercise arm (-14.5%, P = 0.01). Participants randomized to the diet and diet + exercise arms had significant increases in levels of FOP [control -5.81%; diet +14.77% (P = 0.0001); diet + exercise +17.45%, (P = 0.0001)]. In secondary analyses, increasing weight loss was statistically significantly associated with linear trends of greater reductions in oxidized LDL and in F-2-isoprostanes and increases in FOP. Compared with controls, exercise participants whose maximal oxygen consumption increased had significant decreases in levels of F-2-isoprostanes and in oxidized LDL and increases in FOP. Dietary weight loss, with or without exercise, significantly reduced some markers of oxidative stress in postmenopausal women. (C) 2016 AACR.
C1 [Duggan, Catherine; Tapsoba, Jean de Dieu; Wang, Ching-Yun; McTiernan, Anne] Fred Hutchinson Canc Res Ctr, Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA.
   [Wang, Ching-Yun; McTiernan, Anne] Univ Washington, Sch Publ Hlth, Seattle, WA 98195 USA.
   [Campbell, Kristin L.] Univ British Columbia, Fac Med, Vancouver, BC, Canada.
   [Foster-Schubert, Karen] Univ Washington, Sch Med, Seattle, WA USA.
   [Gross, Myron D.] Univ Minnesota, Minneapolis, MN USA.
C3 Fred Hutchinson Cancer Center; University of Washington; University of
   Washington Seattle; University of British Columbia; University of
   Washington; University of Washington Seattle; University of Minnesota
   System; University of Minnesota Twin Cities
RP Duggan, C (corresponding author), Fred Hutchinson Canc Res Ctr, 1100 Fairview Ave N, Seattle, WA 98109 USA.
EM cduggan@fhcrc.org
RI Duggan, Catherine/AAE-9777-2020; Campbell, Kristin/A-5947-2009; Duggan,
   Catherine/F-9414-2015
OI Duggan, Catherine/0000-0001-7369-4021
FU NCI at the NIH [R01 CA105204-01A1, U54-CA116847, R01 CA161131-01A1];
   Breast Cancer Research Foundation
FX This work was supported by grants from the NCI at the NIH (R01
   CA105204-01A1 and U54-CA116847 AMcT; to C. Duggan, C.-Y Wang, K.L.
   Campbell, and K. Foster-Schubert; R01 CA161131-01A1; to A. McTiernan, C.
   Duggan, C.-Y. Wang, and M.D. Gross) and grants from the Breast Cancer
   Research Foundation (to A. McTiernan, C. Duggan, C.-Y. Wang, and J. de
   Dieu Tapsoba,).
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NR 50
TC 32
Z9 33
U1 0
U2 12
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 1940-6207
EI 1940-6215
J9 CANCER PREV RES
JI Cancer Prev. Res.
PD NOV
PY 2016
VL 9
IS 11
BP 835
EP 843
DI 10.1158/1940-6207.CAPR-16-0163
PG 9
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA EB8ZZ
UT WOS:000387682200003
PM 27803047
OA Green Submitted, Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Farrokhian, A
   Raygan, F
   Soltani, A
   Tajabadi-Ebrahimi, M
   Esfahani, MS
   Karami, AA
   Asemi, Z
AF Farrokhian, Alireza
   Raygan, Fariba
   Soltani, Ali
   Tajabadi-Ebrahimi, Maryam
   Esfahani, Mehran Sharifi
   Karami, Ali Akbar
   Asemi, Zatollah
TI The Effects of Synbiotic Supplementation on Carotid Intima-Media
   Thickness, Biomarkers of Inflammation, and Oxidative Stress in People
   with Overweight, Diabetes, and Coronary Heart Disease: a Randomized,
   Double-Blind, Placebo-Controlled Trial (Publication with Expression of
   Concern)
SO PROBIOTICS AND ANTIMICROBIAL PROTEINS
LA English
DT Article; Publication with Expression of Concern
DE Synbiotic supplementation; Carotid intima-media thickness; Inflammation;
   Oxidative stress; Type 2 diabetes mellitus; Coronary heart disease
ID METABOLIC SYNDROME; LIPID PROFILE; PROBIOTICS; MILK; MALONDIALDEHYDE;
   ACTIVATION; MORTALITY; MARKERS; HEALTH
AB Synbiotics are known to exert multiple beneficial effects, including anti-inflammatory and antioxidant actions. The aim of this study was to evaluate the effects of synbiotic supplementation on carotid intima-media thickness (CIMT), biomarkers of inflammation, and oxidative stress in people with overweight, diabetes, and coronary heart disease (CHD). This randomized, double-blind, placebo-controlled trial was conducted and involved 60 people with overweight, diabetes, and CHD, aged 50-85years old. Participants were randomly allocated into two groups to take either synbiotic supplements containing three probiotic bacteria spices Lactobacillus acidophilus strain T16 (IBRC-M10785), Lactobacillus casei strain T2 (IBRC-M10783), and Bifidobacterium bifidum strain T1 (IBRC-M10771) (2x10(9)CFU/g each) plus 800mg inulin or placebo (n=30 each group) for 12weeks. Fasting blood samples were taken at baseline and after the 12-week intervention period to determine metabolic variables. After the 12-week intervention, compared with the placebo, synbiotic supplementation significantly reduced serum high-sensitivity C-reactive protein (hs-CRP) (-3101.7 +/- 5109.1 vs. -6.2 +/- 3163.6ng/mL, P=0.02), plasma malondialdehyde (MDA) (-0.6 +/- 1.0 vs. -0.1 +/- 0.3mol/L, P=0.01), and significantly increased nitric oxide (NO) levels (+7.8 +/- 10.3 vs. -3.6 +/- 6.9mol/L, P<0.001). We did not observe any significant changes of synbiotic supplementation on other biomarkers of oxidative stress and CIMT levels. Overall, synbiotic supplementation for 12weeks among people with overweight, diabetes, and CHD had beneficial effects on serum hs-CRP, plasma NO, and MDA levels; however, it did not have any effect on other biomarkers of oxidative stress and CIMT levels.
C1 [Farrokhian, Alireza; Raygan, Fariba] Kashan Univ Med Sci, Sch Med, Dept Cardiol, Kashan, Iran.
   [Soltani, Ali; Asemi, Zatollah] Kashan Univ Med Sci, Res Ctr Biochem & Nutr Metab Dis, Kashan, Iran.
   [Tajabadi-Ebrahimi, Maryam] Islamic Azad Univ, Sci Dept, Sci Fac, Tehran Cent Branch, Tehran, Iran.
   [Esfahani, Mehran Sharifi] Kashan Univ Med Sci, Sch Med, Dept Oncol, Kashan, Iran.
   [Karami, Ali Akbar] Qazvin Univ Med Sci, Sch Med, Dept Urol, Qazvin, Iran.
C3 Islamic Azad University; Qazvin University of Medical Sciences (QUMS)
RP Asemi, Z (corresponding author), Kashan Univ Med Sci, Res Ctr Biochem & Nutr Metab Dis, Kashan, Iran.
EM asemi_r@yahoo.com
RI Raygan, Fariba/GYU-8723-2022; Soltani, Ali/AFL-8549-2022; Farrokhian,
   Alireza/G-8864-2017; Asemi, Zatollah/G-7393-2017; Soltani,
   Ali/P-2651-2018
OI Soltani, Ali/0000-0001-8042-410X; Raygan, Fariba/0000-0003-3789-5584;
   Sharifi, Mehran/0000-0003-2772-620X
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NR 53
TC 43
Z9 44
U1 1
U2 20
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1867-1306
EI 1867-1314
J9 PROBIOTICS ANTIMICRO
JI Probiotics Antimicrob. Proteins
PD MAR
PY 2019
VL 11
IS 1
BP 133
EP 142
DI 10.1007/s12602-017-9343-1
PG 10
WC Biotechnology & Applied Microbiology; Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Microbiology
GA IC5YH
UT WOS:000471045000014
PM 29079990
DA 2025-06-11
ER

PT J
AU Stephan, D
   Taege, N
   Dore, R
   Folberth, J
   Jöhren, O
   Schwaninger, M
   Lehnert, H
   Schulz, C
AF Stephan, Daniel
   Taege, Natalie
   Dore, Riccardo
   Folberth, Julica
   Joehren, Olaf
   Schwaninger, Markus
   Lehnert, Hendrik
   Schulz, Carla
TI Knockdown of Endogenous Nucb2/Nesfatin-1 in the PVN Leads to Obese-Like
   Phenotype and Abolishes the Metformin- and Stress-Induced Thermogenic
   Response in Rats
SO HORMONE AND METABOLIC RESEARCH
LA English
DT Article
DE energy homeostasis; obesity; metabolic syndrome; oral antidiabetic
   drugs; OAD; diabetes; hypothalamus; NTS; brown adipose tissue
ID NERVOUS-SYSTEM OUTFLOW; PARAVENTRICULAR NUCB2/NESFATIN-1;
   ADIPOSE-TISSUE; NESFATIN-1; NEURONS; LEPTIN; IDENTIFICATION;
   VASOPRESSIN; INHIBITION; OXYTOCIN
AB Nesfatin-1, the cleavage product of nucleobindin-2, is an anorexigenic peptide and major regulator of energy homeostasis. Beyond reducing food intake and increasing energy expenditure, it is also involved in regulating the stress response. Interaction of nucleobindin-2/nesfatin-1 and glucose homeostasis has been observed and recent findings suggest a link between the action of the antidiabetic drug metformin and the nesfatinergic system. Hence, this study aimed to clarify the role of nucleobindin-2/nesfatin-1 in the paraventricular nucleus of the hypothalamus in energy homeostasis as well as its involvement in stress- and metformin-mediated changes in energy expenditure. Knockdown of nucleobindin-2/nesfatin-1 in male Wistar rats led to significantly increased food intake, body weight, and reduced energy expenditure compared to controls. Nucleobindin-2/nesfatin-1 knockdown animals developed an obese-like phenotype represented by significantly increased fat mass and overall increase of circulating lipids. Concomitantly, expression of nucleobindin-2 and melanocortin receptor type 3 and 4 mRNA in the paraventricular nucleus was decreased indicating successful knockdown and impairment at the level of the melanocortin system. Additionally, stress induced activation of interscapular brown adipose tissue was significantly decreased in nucleobindin-2/nesfatin-1 knockdown animals and accompanied by lower adrenal weight. Finally, intracerebroventricular administration of metformin significantly increased energy expenditure in controls and this effect was absent in nucleobindin-2/nesfatin-1 knockdown animals. Overall, we clarified the crucial role of nucleobindin-2/nesfatin-1 in the paraventricular nucleus of the hypothalamus in the regulation of energy homeostasis. The nesfatinergic system was further identified as important mediator in stress- and metformin-induced thermogenesis.
C1 [Stephan, Daniel; Taege, Natalie; Dore, Riccardo; Lehnert, Hendrik; Schulz, Carla] Univ Lubeck, Dept Internal Med 1, Lubeck, Germany.
   [Stephan, Daniel] Johannes Gutenberg Univ Mainz, Dept Oral & Maxillofacial Surg, Univ Med Ctr, Mainz, Germany.
   [Stephan, Daniel; Dore, Riccardo; Folberth, Julica; Joehren, Olaf; Schulz, Carla] Univ Lubeck, Ctr Brain Behav & Metab CBBM, Ratzeburger Allee 160, D-23562 Lubeck, Germany.
   [Taege, Natalie] Univ Lubeck, Inst Human Genet, Sect Epigenet & Metab, Lubeck, Germany.
   [Dore, Riccardo] Univ Lubeck, Inst Endocrinol & Diabet, Lubeck, Germany.
   [Folberth, Julica; Schwaninger, Markus] Univ Lubeck, Inst Expt & Clin Pharmacol & Toxicol, Lubeck, Germany.
   [Lehnert, Hendrik] Paris Lodron Univ Salzburg, Rektorat, Salzburg, Austria.
C3 University of Lubeck; Johannes Gutenberg University of Mainz; University
   of Lubeck; University of Lubeck; University of Lubeck; University of
   Lubeck; Salzburg University
RP Schulz, C (corresponding author), Univ Lubeck, Ctr Brain Behav & Metab CBBM, Ratzeburger Allee 160, D-23562 Lubeck, Germany.
EM carla.schulz@uksh.de
RI Jöhren, Olaf/G-6967-2011; Schwaninger, Markus/JWP-5801-2024
OI Dore, Riccardo/0000-0001-5988-9885; Inderhees,
   Julica/0000-0003-4523-3652; Taege, Natalie/0000-0003-1243-1572;
   Schwaninger, Markus/0000-0002-4510-9718; Johren,
   Olaf/0000-0002-0532-5133
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NR 52
TC 2
Z9 2
U1 0
U2 1
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0018-5043
EI 1439-4286
J9 HORM METAB RES
JI Horm. Metab. Res.
PD NOV
PY 2022
VL 54
IS 11
BP 768
EP 779
DI 10.1055/a-1926-7280
EA OCT 2022
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 6F9MA
UT WOS:000863753000001
PM 36195118
DA 2025-06-11
ER

PT J
AU Berdja, S
   Boudarene, L
   Smail, L
   Neggazi, S
   Boumaza, S
   Sahraoui, A
   Haffaf, E
   Kacimi, G
   Bouguerra, SA
AF Berdja, Sihem
   Boudarene, Lynda
   Smail, Leila
   Neggazi, Samia
   Boumaza, Saliha
   Sahraoui, Abdelhamid
   Haffaf, El-mehdi
   Kacimi, Ghouti
   Aouichat Bouguerra, Souhila
TI Scolymus hispanicus (Golden Thistle) Ameliorates Hepatic
   Steatosis and Metabolic Syndrome by Reducing Lipid Accumulation,
   Oxidative Stress, and Inflammation in Rats under Hyperfatty Diet
SO EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Article
ID FATTY LIVER-DISEASE; GLUCOSE-TOLERANCE; SUCROSE DIET; OBESITY;
   ANTIOXIDANT; SILYMARIN; MOUSE; LIPOTOXICITY; PATHOGENESIS; CHOLESTEROL
AB Background. Lipotoxicity is characterized by a metabolic disturbance leading to the development of nonalcoholic fatty liver disease (NAFLD). Some medicinal plant extracts exert hepatoprotective activity by modulating oxidative stress, inflammation, and metabolic disorders. Scolymus hispanicus or the golden thistle can be considered an important natural source of antioxidants. In traditional medicine, the consumption of this plant is recommended for diseases of the liver and intestines. Objective. In this study, we aimed to determine the effects of Scolymus hispanicus on a hyperfatty diet- (HFD-) induced metabolic disorders, oxidative stress, and inflammation. Materials and Methods. Our experiment focused on the administration of an HFD (40%) in Rattus norvegicus for 2 months and treatment with the aqueous extract of Scolymus hispanicus at a rate of 100 mg/kg during the last eight days of experimentation. In this context, several aspects were studied: the evaluation of blood biochemical parameters, liver function such as lipids and glycogen, markers of oxidative stress (TBARS, carbonyl proteins, advanced oxidation proteins, catalase, and SOD) and inflammation (NO and NFkB), morphological study of hepatocytes in primary culture, and histological study of the liver. Results. Lipotoxicity induced metabolic disorders, both serum and tissue. HFD induced an increase in the total lipids and a decrease in glycogen reserve and an alteration in the oxidant-antioxidant balance. HFD induced an increase in markers of liver damage, which resulted in NAFLD, confirmed by histological study and hepatocytes cell culture. Scolymus appears to have lipid-lowering, hypoglycemic, anti-inflammatory and antioxidant properties. It improved glucose tolerance and the condition of fatty liver disease. Conclusion. Golden thistle improves glucose tolerance and hyperlipidemia and ameliorates hepatic steatosis by reducing oxidative stress, inflammation, and lipid accumulation. Its incorporation into a dietary program or as an aliment supplement would prevent hepatic complications associated with an HFD.
C1 [Berdja, Sihem; Smail, Leila; Neggazi, Samia; Boumaza, Saliha; Sahraoui, Abdelhamid; Aouichat Bouguerra, Souhila] Univ Sci & Technol Houari Boumed, Fac Biol Sci, Lab Cellular & Mol Physiopathol, BP 32 DZ-16011, Algiers, Algeria.
   [Boudarene, Lynda] USTHB, Fac Chem, Lab Organ & Funct Anal, Algiers, Algeria.
   [Haffaf, El-mehdi] Cent Hosp Army, Lab Nucl Med, Algiers, Algeria.
   [Kacimi, Ghouti] Cent Hosp Army, Lab Biochem, Algiers, Algeria.
C3 University Science & Technology Houari Boumediene; University Science &
   Technology Houari Boumediene
RP Berdja, S (corresponding author), Univ Sci & Technol Houari Boumed, Fac Biol Sci, Lab Cellular & Mol Physiopathol, BP 32 DZ-16011, Algiers, Algeria.
EM berdja.sihem@gmail.com; lboudarene@gmail.com; leila84.smail@gmail.com;
   samia.neggazi@gmail.com; boumazasaliha@live.fr; sahraouihamid@yahoo.fr;
   mehdihaffa@gmail.com; ghoutikaci@gmail.com; souhila.aouichat@hotmail.fr
RI Aouichat, Souhila/HKF-7084-2023
OI berdja, sihem/0000-0001-6780-7165
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NR 70
TC 4
Z9 7
U1 0
U2 6
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1741-427X
EI 1741-4288
J9 EVID-BASED COMPL ALT
JI Evid.-based Complement Altern. Med.
PD JUL 12
PY 2021
VL 2021
AR 5588382
DI 10.1155/2021/5588382
PG 14
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA TT7KH
UT WOS:000680523000003
PM 34335826
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Zhang, H
   Shi, L
   Tian, N
   Zhu, M
   Liu, CC
   Hou, TT
   Du, YF
AF Zhang, Heng
   Shi, Lin
   Tian, Na
   Zhu, Min
   Liu, Cuicui
   Hou, Tingting
   Du, Yifeng
TI Association of the atherogenic index of plasma with cognitive function
   and oxidative stress: A population-based study
SO JOURNAL OF ALZHEIMERS DISEASE
LA English
DT Article; Early Access
DE Alzheimer's disease; atherogenic index of plasma; atherosclerosis;
   cognitive impairment; oxidative stress
ID CAROTID ATHEROSCLEROSIS; ALZHEIMERS-DISEASE; METABOLIC SYNDROME;
   LIPID-LEVELS; VITAMIN-D; IMPAIRMENT; CHOLESTEROL; DEMENTIA; DECLINE;
   MEMORY
AB Background: Atherosclerosis contributes to cognitive dysfunction and Alzheimer's disease-related pathologies. Atherogenic index of plasma (AIP) is a novel and composite biomarker can predict atherosclerosis. Objective: This study aims to (1) examine the association between the AIP and cognitive performance, and (2) explore the mediating role of oxidative stress biomarkers in this relationship. Methods 1466 participants over the age of 60 were included from 2011-2014 NHANES. AIP was calculated through log-transformed triglyceride to high-density lipoprotein cholesterol ratios. The assessment of cognition was conducted using the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) test. Weighted linear regression model and restricted cubic spline were carried out to determine the associations between AIP and CERAD scores. The mediation analyses were conducted to assess whether oxidative stress mediates the association. Results: Higher AIP levels were associated with lower CERAD learning scores. The highest quartile of AIP showed a 0.67-fold decrease (95%CI: -1.30, -0.03; p = 0.041) on the CERAD total score than that in the lowest quartile. Each 1-unit increase in AIP corresponded to reductions in CERAD total and delayed recall scores of approximately 1.09 and 0.54 points, respectively, in the sub-population under 70 years. Moreover, 25(OH)D, an oxidative stress indicator, partially mediated 24% of the association between AIP and the CERAD total score. Conclusions: AIP has the potential to indicate the risk of cognitive aging, especially that for young-old or female older adults. The supplementation of 25(OH)D may reduce atherosclerosis-related cognitive decline, which could provide some strategies for the prevention of dementia.
C1 [Zhang, Heng; Shi, Lin; Tian, Na; Zhu, Min; Liu, Cuicui; Hou, Tingting; Du, Yifeng] Shandong First Med Univ, Dept Neurol, Shandong Prov Hosp Affiliated, Jinan, Shandong, Peoples R China.
   [Zhang, Heng; Tian, Na; Zhu, Min; Liu, Cuicui; Hou, Tingting; Du, Yifeng] Shandong Prov Clin Res Ctr Neurol Dis, Jinan, Shandong, Peoples R China.
   [Hou, Tingting; Du, Yifeng] Shandong Univ, Shandong Prov Hosp, Dept Neurol, Jinan, Shandong, Peoples R China.
   [Du, Yifeng] Shandong First Med Univ, Inst Brain Sci & Brain Inspired Res, Jinan, Shandong, Peoples R China.
   [Du, Yifeng] Shandong Acad Med Sci, Jinan, Shandong, Peoples R China.
C3 Shandong First Medical University & Shandong Academy of Medical
   Sciences; Shandong University; Shandong First Medical University &
   Shandong Academy of Medical Sciences; Shandong First Medical University
   & Shandong Academy of Medical Sciences; University of Jinan; Shandong
   First Medical University & Shandong Academy of Medical Sciences
RP Hou, TT; Du, YF (corresponding author), Shandong First Med Univ, Dept Neurol, Shandong Prov Hosp Affiliated, Jinan, Shandong, Peoples R China.
EM httl-001@163.com; duyifeng2013@163.com
RI Hou, Tingting/LMN-6758-2024; Du, Yifeng/IST-9657-2023
FU National Key R&D Program of China [2022YFC3501404]; Brain Science and
   Brain-Like Intelligence Technology Research Projects of China
   [2021ZD0201801, 2021ZD0201808]; Natural Science Foundation of Shandong
   Province [ZR2023QH019, ZR2021MH392, ZR2021QH240]; Shandong Provincial
   Key Research and Development Program [2021LCZX03]; Shandong Provincial
   Hospital Research Incubation Fund [2022FY112]
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: This work
   was supported in part by grants from the National Key R&D Program of
   China (grant no.: 2022YFC3501404), the Brain Science and Brain-Like
   Intelligence Technology Research Projects of China (grant no.:
   2021ZD0201801 and 2021ZD0201808), the Natural Science Foundation of
   Shandong Province (grant no.: ZR2023QH019, ZR2021MH392 and ZR2021QH240),
   the Shandong Provincial Key Research and Development Program (grant no.:
   2021LCZX03), and the Shandong Provincial Hospital Research Incubation
   Fund (grant no.: 2022FY112).
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NR 53
TC 0
Z9 0
U1 1
U2 1
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1387-2877
EI 1875-8908
J9 J ALZHEIMERS DIS
JI J. Alzheimers Dis.
PD 2025 MAY 7
PY 2025
DI 10.1177/13872877251334826
EA MAY 2025
PG 12
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 2IX8P
UT WOS:001483748100001
PM 40336259
DA 2025-06-11
ER

PT J
AU Zhao, F
   Pang, WT
   Zhang, ZY
   Zhao, JL
   Wang, X
   Liu, Y
   Wang, X
   Feng, ZH
   Zhang, Y
   Sun, WY
   Liu, JK
AF Zhao, Fei
   Pang, Wentao
   Zhang, Ziyi
   Zhao, Jialong
   Wang, Xin
   Liu, Ye
   Wang, Xun
   Feng, Zhihui
   Zhang, Yong
   Sun, Wenyan
   Liu, Jiankang
TI Pomegranate extract and exercise provide additive benefits on
   improvement of immune function by inhibiting inflammation and oxidative
   stress in high-fat-diet-induced obesity in rats
SO JOURNAL OF NUTRITIONAL BIOCHEMISTRY
LA English
DT Article
DE Pomegranate extract; Exercise; Immune function; Inflammation; Oxidative
   stress; Obesity
ID INSULIN-RESISTANCE; TISSUE MACROPHAGES; METABOLIC SYNDROME;
   ADIPOSE-TISSUE; T-LYMPHOPENIA; LIVER-DISEASE; SEED OIL; MICE; RESPONSES;
   DYSFUNCTION
AB Background: Obesity, is reported to be associated with immune dysfunction and a state of low-grade, chronic inflammation. Either pomegranate extract (PomE) or exercise (Ex) has been shown to have antiobesity, anti-inflammatory and antioxidant effects. Nevertheless, no study has addressed the additive benefits of PomE and Ex on the restoration of obesity-induced immune defects.
   Objective: The present work aims to study the effect of PomE and Ex as a combined intervention on immune function and the underlying mechanism involved in inflammation and oxidative stress in rats with high-fat-diet (HFD)-induced obesity.
   Results: Our results demonstrate that the combination of PomE and Ex showed additive benefits on inhibition of HFD-induced body weight increase and improvement of HFD-induced immune dysfunction, including (a) attenuating the abnormality of histomorphology of the spleen, (b) increasing the ratio of the CD4 +:CD8 + T cell subpopulations in splenocytes and peripheral blood mononuclear cells (PBMC), (c) inhibition of apoptosis in splenocytes and PBMC, (d) normalizing peritoneal macrophage phenotypes and (e) restoring immunomodulating factors in serum. We also find that immune dysfunction in HFD-fed rats was associated with increased inflammatory cytokine secretion and oxidative stress biomarkers, and that the combination of PornE and Ex effectively inhibited the inflammatory response and decreased oxidative damage.
   Conclusions: The effect of PomE and Ex as a combined intervention is greater than the effect of either PomE or Ex alone, showing that PomE and Ex may be additively effective in improving immune function in HFD-fed rats by inhibiting inflammation and decreasing oxidative stress. (C) 2016 Elsevier Inc. All rights reserved.
C1 [Zhao, Fei; Pang, Wentao; Zhang, Ziyi; Zhao, Jialong; Zhang, Yong; Liu, Jiankang] Tianjin Univ Sport, Tianjin Key Lab Exercise Physiol & Sports Med, Tianjin 300381, Peoples R China.
   [Liu, Ye; Wang, Xun; Feng, Zhihui; Zhang, Yong; Liu, Jiankang] Xi An Jiao Tong Univ, Sch Life Sci & Technol, Ctr Mitochondrial Biol & Med, Key Lab Biomed Informat Engn,Minist Educ, Xian 710049, Peoples R China.
   [Liu, Ye; Wang, Xun; Feng, Zhihui; Zhang, Yong; Liu, Jiankang] Xi An Jiao Tong Univ, Frontier Inst Sci & Technol, Xian 710049, Peoples R China.
   [Wang, Xin] Shaanxi Prov Peoples Hosp, Dept Cent Lab, Xian 710068, Peoples R China.
   [Sun, Wenyan] Xi An Jiao Tong Univ, Sch Publ Hlth, Dept Nutr & Food Secur, 76 Yanta West Rd, Xian 710061, Peoples R China.
C3 Tianjin University of Sport; Ministry of Education - China; Xi'an
   Jiaotong University; Xi'an Jiaotong University; Xi'an Medical
   University; Xi'an Jiaotong University
RP Sun, WY; Liu, JK (corresponding author), Xi An Jiao Tong Univ, Sch Publ Hlth, Dept Nutr & Food Secur, 76 Yanta West Rd, Xian 710061, Peoples R China.
EM wenyan2014@mail.xjtu.edu.cn; j.liu@mail.xjtu.edu.cn
RI Liu, Jiankang/A-1610-2011; Feng, Zhihui/E-7408-2011
OI Sun, Wenyan/0000-0002-3186-5002; Feng, Zhihui/0000-0002-2448-6565; Wang,
   Xun/0000-0001-5172-0305
FU Tianjin Science and Technology Planning Major Project [12JCZDJC34400];
   Tianjin Education Committee Sci-Tech Development Major Project
   [20112D05]; Tianjin Key Labs and Tech-Platform Project [10SYSYJC28400];
   Tianjin Science and Technology Planning [09JCYBJC12000]; 973 Plan
   Project of the Ministry of Science and Technology of China
   [2015CB553602]
FX This work was supported by the Tianjin Science and Technology Planning
   Major Project (12JCZDJC34400), the Tianjin Education Committee Sci-Tech
   Development Major Project (20112D05), the Tianjin Key Labs and
   Tech-Platform Project (10SYSYJC28400), the Tianjin Science and
   Technology Planning (09JCYBJC12000) and the 973 Plan Project of the
   Ministry of Science and Technology of China (2015CB553602).
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NR 28
TC 29
Z9 31
U1 0
U2 29
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0955-2863
EI 1873-4847
J9 J NUTR BIOCHEM
JI J. Nutr. Biochem.
PD JUN
PY 2016
VL 32
BP 20
EP 28
DI 10.1016/j.jnutbio.2016.02.003
PG 9
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA DO2TZ
UT WOS:000377634300002
PM 27142733
DA 2025-06-11
ER

PT J
AU Watterson, TL
   Hamilton, B
   Martin, R
   Coulombe, RA
AF Watterson, Todd L.
   Hamilton, Brett
   Martin, Randy
   Coulombe, Roger A., Jr.
TI Urban Particulate Matter Causes ER Stress and the Unfolded Protein
   Response in Human Lung Cells
SO TOXICOLOGICAL SCIENCES
LA English
DT Article
DE unfolded protein response; calpain; PERK; C-reactive protein;
   particulate air pollution; PM2.5; PM10; Hsp70; Hsp90; Hsp27; caspase-3;
   caspase-9; lipopolysaccharide
ID ENDOPLASMIC-RETICULUM STRESS; C-REACTIVE PROTEIN; SYSTEMIC INFLAMMATORY
   RESPONSE; AIR-POLLUTION PARTICLES; TOLL-LIKE RECEPTOR-2; LONG-TERM
   EXPOSURE; EPITHELIAL-CELLS; CACHE VALLEY; METABOLIC SYNDROME; SIGNALING
   PATHWAY
AB Because of its presumed adverse health effects, particulate air pollution (PM) has received growing attention, but the cellular mechanisms by which PM exerts toxicity are not well elucidated. PM has been associated with early mortality from illnesses that share endoplasmic reticulum (ER) stress as a mechanism of pathogenesis. In this study, we examined whether PM would induce the unfolded protein response (UPR) which is a cellular response to ER stress. Coarse (PM10) and fine (PM2.5) PM was collected from a single location in Northern Utah's Cache Valley during atmospheric inversions occurring in January 2002 and January 2003. Extracts of PM samples were added (12.5 and 25 mu g/ml) to cultured human bronchial epithelial (BEAS-2B) cells for 24 h. At these concentrations neither PM nor LPS exhibited demonstrable cytotoxicity by the neutral red assay. However, PM elicited significant increases of unfolded protein response (UPR)-related post-translational modifications, such as S6 ribosomal protein, heat-shock protein (Hsp)27, and protein kinase related protein phosphorylation and cleavage of activating transcription factor (ATF)-6. PM exposure also resulted in significant increases in the UPR-associated proteins ATF-4, Hsp70, Hsp90, and binding immunoglobulin protein. PM also interfered with the export of Hsp70 from the cells in a concentration-dependent manner and resulted in release of C-reactive protein. Calpain was upregulated and activated in PM-treated cultures, though these events were not proapoptotic. This study demonstrates that PM is capable of inducing ER stress and the UPR in vitro and may be a mechanism by which PM exerts toxicity.
C1 [Watterson, Todd L.; Hamilton, Brett; Coulombe, Roger A., Jr.] Utah State Univ, Grad Program Toxicol, Logan, UT 84322 USA.
   [Watterson, Todd L.; Hamilton, Brett; Coulombe, Roger A., Jr.] Utah State Univ, Dept Vet Sci, Logan, UT 84322 USA.
   [Martin, Randy] Utah State Univ, Dept Civil & Environm Engn, Logan, UT 84322 USA.
C3 Utah System of Higher Education; Utah State University; Utah System of
   Higher Education; Utah State University; Utah System of Higher
   Education; Utah State University
RP Coulombe, RA (corresponding author), Utah State Univ, Grad Program Toxicol, 4620 Old Main Hill, Logan, UT 84322 USA.
EM roger@usu.edu
RI Coulombe, Roger/G-7523-2012
FU Marriner S. Eccles Foundation; Utah State University
FX Marriner S. Eccles Foundation; a National Children's Study pilot project
   grant from Utah State University; Utah Agricultural Experiment Station,
   where this is published as paper number 8125.
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NR 84
TC 55
Z9 66
U1 0
U2 30
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1096-6080
EI 1096-0929
J9 TOXICOL SCI
JI Toxicol. Sci.
PD NOV
PY 2009
VL 112
IS 1
BP 111
EP 122
DI 10.1093/toxsci/kfp186
PG 12
WC Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Toxicology
GA 514IO
UT WOS:000271387900011
PM 19675143
DA 2025-06-11
ER

PT J
AU Koloverou, E
   Panagiotakos, DB
   Pitsavos, C
   Chrysohoou, C
   Georgousopoulou, EN
   Grekas, A
   Christou, A
   Chatzigeorgiou, M
   Skoumas, I
   Tousoulis, D
   Stefanadisa, C
AF Koloverou, E.
   Panagiotakos, D. B.
   Pitsavos, C.
   Chrysohoou, C.
   Georgousopoulou, E. N.
   Grekas, A.
   Christou, A.
   Chatzigeorgiou, M.
   Skoumas, I.
   Tousoulis, D.
   Stefanadisa, C.
CA ATTICA Study Grp
TI Adherence to Mediterranean diet and 10-year incidence (2002-2012) of
   diabetes: correlations with inflammatory and oxidative stress biomarkers
   in the ATTICA cohort study
SO DIABETES-METABOLISM RESEARCH AND REVIEWS
LA English
DT Article
DE cohort study; Mediterranean diet; risk; type 2 diabetes; oxidative
   stress; inflammation
ID INSULIN-RESISTANCE; HEALTHY-ADULTS; WEIGHT-LOSS; ANTIOXIDANT CAPACITY;
   METABOLIC SYNDROME; MARKERS; MELLITUS; OBESITY; RISK; FAT
AB BackgroundThe purpose of this work was to investigate the links between oxidative stress, inflammation and coagulation and their effect on Mediterranean diet-diabetes relationship.
   MethodsIn 2001-2002, a random sample of 1514 men (18-87years old) and 1528 women (18-89years old) was selected to participate in the ATTICA study, where Athens is the major metropolis. A validated questionnaire was used to assess lifestyle and dietary factors. Adherence to Mediterranean diet was recorded using MedDietScore. Among others, oxidative stress and inflammatory biomarkers were recorded. During 2011-2012, the 10-year follow-up was performed. Diabetes incidence was defined according to the American Diabetes Association criteria.
   ResultsA total of 191 incident cases of diabetes were documented, yielding an incidence of 12.9% (13.4% in men and 12.4% in women). Medium and high adherence was found to decrease diabetes risk by 49% (95% CI: 0.30, 0.88) and 62% (95% CI: 0.16, 0.88), respectively, compared with low adherence. A logarithmic trend between Mediterranean diet and diabetes incidence was also revealed (p for trend=0.042). Individuals with abnormal waist circumference (>94 for men, >80 for women) were benefited the most. Wholegrain cereals, fruits and legumes had the greatest predictive ability. The anti-diabetic effect of Mediterranean diet correlated with measurements of tumour necrosis factor-, homocysteine and total antioxidant capacity.
   ConclusionsThe reported results support the role of Mediterranean diet as a promising dietary tool for the primary prevention of diabetes, by attenuating inflammation and fostering total antioxidant capacity. This dietary pattern may have therapeutic potential for many cardiometabolic disorders associated with inflammation and/or oxidative stress. Copyright (c) 2015 John Wiley & Sons, Ltd.
C1 [Koloverou, E.; Panagiotakos, D. B.; Georgousopoulou, E. N.; Grekas, A.; Christou, A.; Chatzigeorgiou, M.] Harokopio Univ, Sch Hlth Sci & Educ, Dept Nutr & Dietet, Athens 16674, Attica, Greece.
   [Pitsavos, C.; Chrysohoou, C.; Skoumas, I.; Tousoulis, D.; Stefanadisa, C.] Univ Athens, Sch Med, Cardiol Clin 1, GR-10679 Athens, Greece.
C3 Harokopio University Athens; Athens Medical School; National &
   Kapodistrian University of Athens
RP Panagiotakos, DB (corresponding author), Harokopio Univ, Sch Hlth Sci & Educ, Dept Nutr & Dietet, 46 Paleon Polemiston St Glyfada, Athens 16674, Attica, Greece.
EM d.b.panagiotakos@usa.net
RI Panagiotakos, Demosthenes/K-8294-2019; Georgousopoulou,
   Ekavi/AAC-2563-2019; Stefanadis, Christodoulos/ABH-2232-2020;
   papadimitriou, lampros/I-3316-2013
OI Stefanadis, Christodoulos/0000-0001-5974-6454; papadimitriou,
   lampros/0000-0003-3356-0963; Chrysohoou, Christina/0000-0002-6340-3996
FU Coca-Cola SA [10.9.2013]
FX The authors would like to thank the ATTICA study group of investigators:
   Yannis Skoumas, Natassa Katinioti, Labros Papadimitriou, Constantina
   Masoura, Spiros Vellas, Yannis Lentzas, Manolis Kambaxis, Konstadina
   Palliou, Vassiliki Metaxa, Agathi Ntzouvani, Dimitris Mpougatsas,
   Nikolaos Skourlis, Christina Papanikolaou, Georgia-Maria Kouli, Aimilia
   Christou, Adella Zana, Maria Ntertimani, Aikaterini Kalogeropoulou,
   Evangelia Pitaraki, Alexandros Laskaris, Mihail Hatzigeorgiou and
   Athanasios Grekas for their assistance in the initial physical
   examination and follow-up evaluation, Efi Tsetsekou for her assistance
   in psychological evaluation as well as the laboratory team: Carmen
   Vassiliadou and George Dedoussis (genetic analysis), Marina
   Toutouza-Giotsa, Constadina Tselika and Sia Poulopoulou (biochemical
   analysis) and Maria Toutouza for the database management. Demosthenes
   Panagiotakos and Ekavi Georgousopoulou received research grants from
   Coca-Cola SA (10.9.2013).
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NR 40
TC 99
Z9 101
U1 0
U2 26
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1520-7552
EI 1520-7560
J9 DIABETES-METAB RES
JI Diabetes-Metab. Res. Rev.
PD JAN
PY 2016
VL 32
IS 1
BP 73
EP 81
DI 10.1002/dmrr.2672
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA DA7VE
UT WOS:000368012000008
PM 26104243
DA 2025-06-11
ER

PT J
AU von Bibra, H
   Sutton, MS
   Schuster, T
   Ceriello, A
   Siegmund, T
   Schumm-Draeger, PM
AF von Bibra, H.
   Sutton, M. St John
   Schuster, T.
   Ceriello, A.
   Siegmund, T.
   Schumm-Draeger, P. -M.
TI Oxidative Stress after a Carbohydrate Meal Contributes to the
   Deterioration of Diastolic Cardiac Function in Nonhypertensive
   Insulin-treated Patients with Moderately Well Controlled Type 2 Diabetes
SO HORMONE AND METABOLIC RESEARCH
LA English
DT Article
DE diastolic function; type 2 diabetes; oxidative stress; postmeal
   hyperglycemia; tissue Doppler
ID METABOLIC SYNDROME; HEART; GLUCOSE; HYPERGLYCEMIA; PATHOGENESIS;
   DYSFUNCTION; PREVENTION; RESISTANCE; STIFFNESS; PERFUSION
AB The prevalence and prognostic importance of diastolic dysfunction in type 2 diabetes has only recently been appreciated. We tested the hypothesis that in insulin treated type 2 diabetes (D), carbohydrate consumption induces oxidative stress resulting in further impairment of diastolic function beyond structural myocardial stiffness. The effects of a pure carbohydrate breakfast (48 g) on oxidative stress and cardiac function were studied in the fasting and postmeal states in subjects without hypertension or overt cardiac disease (moderately well controlled D, n = 21 and controls without D, n = 20). Studied variables included systolic and early diastolic (E') myocardial velocities, traditional metabolic and hemo-dynamic parameters, serum nitrotyrosine, and sVCAM-1. In D compared to control subjects, the postmeal increase (Delta) in glucose (1.44 +/- 2.78 vs. 0.11 +/- 0.72 mmol/l, p = 0.04) and. nitrotyrosine (0.34 +/- 0.37 vs. -0.23 +/- 0.47 nM/l, p < 0.001) were significantly higher. sVCAM-1 was higher in fasting and postmeal (p = 0.02). E' was significantly lower in postmeal (7.3 +/- 1.3 vs. 9.6 +/- 1.3 cm/s, p < 0.001) and fasting (p < 0.001) whereas the rate pressure product was significantly higher (9 420 +/- 1 118 vs. 7 705 +/- 1 871 mm Hg/min, p < 0.001). Multivariable regression models of the pooled data demonstrated that independent predictors for postmeal E' were Delta nitrotyrosine and septal thickness (R-2 0.466) and for fasting E' age, Delta nitrotyrosine, and septal thickness (R-2 0.400). In insulin requiring type 2 diabetes, carbohydrate consumption may induce oxidative stress that is associated with worsening diastolic function, indicating that this metabolic factor is an important determinant of diastolic dysfunction in the diabetic heart beyond the increase in structural myocardial stiffness.
C1 [von Bibra, H.; Siegmund, T.; Schumm-Draeger, P. -M.] Tech Univ Munich, Teaching Hosp Munchen Bogenhausen, Dept Endocrinol Diabet & Vasc Med, D-80290 Munich, Germany.
   [Sutton, M. St John] Univ Penn, Sch Med, Dept Med, Div Cardiovasc, Philadelphia, PA 19104 USA.
   [Schuster, T.] Tech Univ Munich, Inst Stat & Epidemiol Med, D-80290 Munich, Germany.
   [Ceriello, A.] Inst Invest Biomed August Pi & Sunyer IDIBAPS, Barcelona, Spain.
   [Ceriello, A.] Ctr Invest Biomed Red Diabet & Enfermedades Metab, Barcelona, Spain.
C3 Technical University of Munich; University of Pennsylvania; Technical
   University of Munich; University of Barcelona; Hospital Clinic de
   Barcelona; IDIBAPS; CIBER - Centro de Investigacion Biomedica en Red;
   CIBERDEM
RP von Bibra, H (corresponding author), Stadt Klinikum Munchen GmbH, Klinikum Bogenhausen, Englschalkingerstr 77, D-81925 Munich, Germany.
EM vonbibra@gmx.de
RI Ceriello, Antonio/J-9575-2016; Schuster, Tibor/LQJ-4546-2024
OI Ceriello, Antonio/0000-0001-8122-3203
CR [Anonymous], 2012, NAT REV ENDOCRINOL
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NR 33
TC 14
Z9 14
U1 0
U2 2
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0018-5043
EI 1439-4286
J9 HORM METAB RES
JI Horm. Metab. Res.
PD JUN
PY 2013
VL 45
IS 6
BP 449
EP 455
DI 10.1055/s-0033-1333752
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 180BX
UT WOS:000321569000008
PM 23426860
DA 2025-06-11
ER

PT J
AU Katsuki, A
   Suematsu, M
   Gabazza, EC
   Murashima, S
   Nakatani, K
   Togashi, K
   Yano, Y
   Adachi, Y
   Sumida, Y
AF Katsuki, Akira
   Suematsu, Mina
   Gabazza, Esteban C.
   Murashima, Shuichi
   Nakatani, Kaname
   Togashi, Kenji
   Yano, Yutaka
   Adachi, Yukihiko
   Sumida, Yasuhiro
TI Increased oxidative stress is associated with decreased circulating
   levels of adiponectin in Japanese metabolically obese, normal-weight men
   with normal glucose tolerance
SO DIABETES RESEARCH AND CLINICAL PRACTICE
LA English
DT Article
DE oxidative stress; adiponectin; metabolical obesity; metabolic syndrome;
   Japanese men
ID INSULIN-RESISTANCE; SERUM-LEVELS; TRIGLYCERIDE; FAT
AB To investigate the relationship between oxidative stress and circulating levels of adiponectin in Japanese metabolically obese, normal-weight [MONW; BMI < 25 and visceral fat area; VFA >= 100 cm 2 by abdominal computed tomography (CT) scanning] men with normal glucose tolerance (NGT), we measured the plasma levels of free 8-epi-prostaglandin F2 alpha (8-epi-PGF2 alpha) and adiponectin in 28 MONW and 23 normal men. The plasma levels of free 8-epi-PGF2 alpha were measured using a commercially available enzyme immunoassay (EIA) kit (Cayman Chemical, Ann Arbor, MI). The plasma levels of adiponectin were measured using a radioimmunoassay kit (LINCO Research, St. Charles, MO). Plasma levels of 8-epi-PGF2 alpha in MONW subjects (30.4 +/- 4.0 pg/ml; P < 0.01) were significantly increased compared to controls (8.1 +/- 1.3 pg/ml). The plasma levels of adiponectin were significantly decreased in MONW subjects (8.6 +/- 0.9 mu g/ml; P < 0.01) as compared to normal subjects (11.6 +/- 0.6 mu g/ml). The plasma levels of 8-epi-PGF2 alpha and adiponectin were significantly correlated in MONW (r = -0.617, P < 0.01) and in all (MONW + normal) (r = -0.620, P < 0.01) subjects. The plasma levels of 8-epi-PGF2 alpha and adiponectin were significantly correlated after adjustment for VFA in MONW subjects (F = 11.042, P < 0.01). The present study showed that systemic increase in oxidative stress correlates with decreased circulating levels of adiponectin in Japanese MONW men with NGT. Although correlation does not prove causation, this observation suggests that increased oxidative stress may decrease the production of adiponectin in Japanese MONW men with NGT. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
C1 Mie Univ, Sch Med, Dept Internal Med, Div Diabetol & Endocrinol, Tsu, Mie 5148507, Japan.
   Mie Univ, Sch Med, Div Pulm & Crit Care Med, Dept Internal Med, Tsu, Mie, Japan.
   Mie Univ, Sch Med, Dept Radiol, Tsu, Mie, Japan.
   Mie Univ, Sch Med, Dept Lab Med, Tsu, Mie, Japan.
   Mie Univ, Sch Educ, Dept Hlth & Phys Educ, Tsu, Mie, Japan.
C3 Mie University; Mie University; Mie University; Mie University; Mie
   University
RP Sumida, Y (corresponding author), Mie Univ, Sch Med, Dept Internal Med, Div Diabetol & Endocrinol, 2-174 Edobashi, Tsu, Mie 5148507, Japan.
EM sumidaya@clin.medic.mie-u.ac.jp
RI Suematsu, Mina/R-1046-2019; Gabazza, Esteban/HTO-2503-2023; Suematsu,
   Makoto/I-8135-2013
OI Nakatani, Kaname/0000-0001-6709-541X; Suematsu,
   Makoto/0000-0002-7165-6336; Suematsu, Mina/0000-0003-1874-0018; Gabazza,
   Esteban/0000-0001-5748-1499
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NR 27
TC 45
Z9 50
U1 0
U2 5
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0168-8227
EI 1872-8227
J9 DIABETES RES CLIN PR
JI Diabetes Res. Clin. Pract.
PD SEP
PY 2006
VL 73
IS 3
BP 310
EP 314
DI 10.1016/j.diabres.2006.02.014
PG 5
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 074ZT
UT WOS:000239852100012
PM 16631275
DA 2025-06-11
ER

PT J
AU Bovi, APD
   Marciano, F
   Mandato, C
   Siano, MA
   Savoia, M
   Vajro, P
AF Bovi, Anna Pia Delli
   Marciano, Francesca
   Mandato, Claudia
   Siano, Maria Anna
   Savoia, Marcella
   Vajro, Pietro
TI Oxidative Stress in Non-alcoholic Fatty Liver Disease. An Updated Mini
   Review
SO FRONTIERS IN MEDICINE
LA English
DT Review
DE non-alcoholic fatty liver disease; oxidative stress; antioxidants;
   obstructive sleep apnea syndrome; gut microbiota; obesity; metabolic
   syndrome
ID ENDOPLASMIC-RETICULUM STRESS; OBSTRUCTIVE SLEEP-APNEA; VITAMIN-E; GUT
   MICROBIOTA; REACTIVE OXYGEN; INSULIN-RESISTANCE; MITOCHONDRIAL
   DYSFUNCTION; NONDIABETIC PATIENTS; CYTOCHROME-P450 2E1; HEPATIC
   STEATOSIS
AB Non-alcoholic fatty liver disease (NAFLD) is a challenging disease caused by multiple factors, which may partly explain why it remains still orphan of an adequate therapeutic strategy. Herein we focus on the interplay between oxidative stress (OS) and the other causal pathogenetic factors. Different reactive oxygen species (ROS) generators contribute to NAFLD inflammatory and fibrotic progression, which is quite strictly linked to the lipotoxic liver injury from fatty acids and/or a wide variety of their biologically active metabolites in the context of either a two-hit or a (more recent) multiple parallel hits theory. An antioxidant defense system is usually able to protect hepatic cells from damaging effects caused by ROS, including those produced into the gastrointestinal tract, i.e., by-products generated by usual cellular metabolic processes, normal or dysbiotic microbiota, and/or diet through an enhanced gut-liver axis. Oxidative stress originating from the imbalance between ROS generation and antioxidant defenses is under the influence of individual genetic and epigenetic factors as well. Healthy diet and physical activity have been shown to be effective on NAFLD also with antioxidant mechanisms, but compliance to these lifestyles is very low. Among several considered antioxidants, vitamin E has been particularly studied; however, data are still contradictory. Some studies with natural polyphenols proposed for NAFLD prevention and treatment are encouraging. Probiotics, prebiotics, diet, or fecal microbiota transplantation represent new therapeutic approaches targeting the gut microbiota dysbiosis. In the near future, precision medicine taking into consideration genetic or environmental epigenetic risk factors will likely assist in further selecting the treatment that could work best for a specific patient.
C1 [Bovi, Anna Pia Delli; Marciano, Francesca; Siano, Maria Anna; Vajro, Pietro] Univ Salerno, Pediat Sect, Scuola Med Salernitana, Dept Med & Surg, Baronissi, Italy.
   [Marciano, Francesca; Savoia, Marcella] Univ Naples Federico II, Dept Mol Med & Med Biotechnol, Naples, Italy.
   [Mandato, Claudia] Santobono Pausilipon Childrens Hosp, Dept Pediat, Naples, Italy.
C3 University of Salerno; University of Naples Federico II
RP Mandato, C (corresponding author), Santobono Pausilipon Childrens Hosp, Dept Pediat, Naples, Italy.
EM cla.mandato@gmail.com
RI Mandato, Claudia/G-6367-2018; siano, maria anna/GQH-7630-2022; Vajro,
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OI siano, maria anna/0000-0001-8991-8261; Savoia,
   Marcella/0000-0003-2283-093X
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NR 163
TC 194
Z9 196
U1 3
U2 89
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 2296-858X
J9 FRONT MED-LAUSANNE
JI Front. Med.
PD FEB 26
PY 2021
VL 8
AR 595371
DI 10.3389/fmed.2021.595371
PG 14
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA QV2CZ
UT WOS:000627785800001
PM 33718398
OA Green Published, gold
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Deng, JL
   Wang, M
   Guo, YK
   Fischer, H
   Yu, XC
   Kem, D
   Li, HL
AF Deng, Jielin
   Wang, Meng
   Guo, Yankai
   Fischer, Hayley
   Yu, Xichun
   Kem, David
   Li, Hongliang
TI Activation of α7nAChR via vagus nerve prevents obesity-induced insulin
   resistance via suppressing endoplasmic reticulum stress-induced
   inflammation in Kupffer cells
SO MEDICAL HYPOTHESES
LA English
DT Article
ID NICOTINIC ACETYLCHOLINE-RECEPTORS; UNFOLDED PROTEIN RESPONSE; HEPATIC
   LIPID-ACCUMULATION; ADIPOSE-TISSUE; WEIGHT-LOSS; REPERFUSION INJURY; ER
   STRESS; KAPPA-B; STIMULATION; METABOLISM
AB Obesity is a major risk factor for type 2 diabetes mellitus and insulin resistance (IR). In the state of obesity, excess fat accumulates in the liver, a key organ in systemic metabolism, altering the inflammatory and metabolic signals contributing substantially to the development of hepatic IR. Current therapies for these metabolic disorders have not been able to reverse their rapidly rising prevalence. One of the reasons is that the effects of existing drugs are predominantly non-lasting [1,2]. The vagus nerve (VN) is known to play an essential role in maintaining metabolic homeostasis while decreased VN activity has been suggested to contribute to obesity associated metabolic syndrome [3,4]. Several studies have reported that activation of alpha 7 nicotinic acetylcholine receptor (alpha 7nAChR) cholinergic signaling with or without VN intervention has protective effects against obesity-related inflammation and other metabolic complications [5]. However, the molecular mechanisms are still not elucidated. Exaggerated endoplasmic reticulum (ER) stress and consequent dysregulated inflammation has been implicated in the development of lipid accumulation and IR [6]. Whether targeting alpha 7nAChR can regulate IR through these pathways is rarely reported. Accordingly, the present proposal posits that activation of the alpha 7nAChR by VNS attenuates ER stress induced inflammation, thus ameliorating hepatic IR in Kupffer cell. We will focus on the specific interaction between vagal cholinergic activity and the modulation of ER stress induced inflammation via the alpha 7nAChR associated pathway during IR development. Recently, the Endocrine Society has emphasized the absence of specific evidence from basic science, clinical, and epidemiological literature to assess current knowledge regarding underlying mechanisms of obesity [7]. In this proposal, we assign a significant role to alpha 7nAChR in obesity-induced hepatic IR, and suggest a possible therapeutic strategy with VNS intervention.
C1 [Deng, Jielin; Guo, Yankai; Fischer, Hayley; Yu, Xichun; Kem, David; Li, Hongliang] Univ Oklahoma, Hlth Sci Ctr, Dept Med, Oklahoma City, OK USA.
   [Deng, Jielin; Wang, Meng] Wuhan Univ, Renmin Hosp, Dept Cardiol, Wuhan, Peoples R China.
   [Guo, Yankai] Xinjiang Med Univ, Affiliated Hosp 1, Cardiac Pacing & Electrophysiol Dept, Urumqi, Peoples R China.
C3 University of Oklahoma System; University of Oklahoma Health Sciences
   Center; Wuhan University; Xinjiang Medical University
RP Li, HL (corresponding author), 1122 NE 13th St,ORB 329, Oklahoma City, OK 73117 USA.
EM hongliang-li@ouhsc.edu
RI Li, Hongliang/AAV-1697-2020
OI Deng, Jielin/0000-0002-9384-0687
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NR 65
TC 7
Z9 7
U1 0
U2 8
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0306-9877
EI 1532-2777
J9 MED HYPOTHESES
JI Med. Hypotheses
PD JUL
PY 2020
VL 140
AR 109671
DI 10.1016/j.mehy.2020.109671
PG 5
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA LY7PY
UT WOS:000540720800002
PM 32182560
DA 2025-06-11
ER

PT J
AU Habeos, GI
   Filippopoulou, F
   Habeos, EE
   Kalaitzopoulou, E
   Skipitari, M
   Papadea, P
   Lagoumintzis, G
   Niarchos, A
   Georgiou, CD
   Chartoumpekis, DV
AF Habeos, George I.
   Filippopoulou, Fotini
   Habeos, Evagelia E.
   Kalaitzopoulou, Electra
   Skipitari, Marianna
   Papadea, Polyxeni
   Lagoumintzis, George
   Niarchos, Athanasios
   Georgiou, Christos D.
   Chartoumpekis, Dionysios V.
TI Maternal Calorie Restriction Induces a Transcriptional Cytoprotective
   Response in Embryonic Liver Partially Dependent on Nrf2
SO ANTIOXIDANTS
LA English
DT Article
DE Keap1; Nfe2l2; reactive oxygen species; oxidative stress;
   gluconeogenesis; lipogenesis; integrative stress response; embryo
ID GLUTATHIONE S-TRANSFERASES; OXIDATIVE STRESS; IN-UTERO;
   DIABETES-MELLITUS; PRENATAL EXPOSURE; KEAP1-NRF2 SYSTEM; GROWTH; MOUSE;
   EXPRESSION; MECHANISM
AB Background: Calorie restriction is known to enhance Nrf2 signaling and longevity in adult mice, partially by reducing reactive oxygen species, but calorie restriction during pregnancy leads to intrauterine growth retardation. The latter is associated with fetal reprogramming leading to increased incidence of obesity, metabolic syndrome and diabetes in adult life. Transcription factor Nrf2 is a central regulator of the antioxidant response and its crosstalk with metabolic pathways is emerging. We hypothesized that the Nrf2 pathway is induced in embryos during calorie restriction in pregnant mothers. Methods: From gestational day 10 up to day 16, 50% of the necessary mouse diet was provided to Nrf2 heterozygous pregnant females with fathers being of the same genotype. Embryos were harvested at the end of gestational day 16 and fetal liver was used for qRT-PCR and assessment of oxidative stress (OS). Results: Intrauterine calorie restriction led to upregulation of mRNA expression of antioxidant genes (Nqo1, Gsta1, Gsta4) and of genes related to integrated stress response (Chac1, Ddit3) in WT embryos. The expression of a key gluconeogenic (G6pase) and two lipogenic genes (Acacb, Fasn) was repressed in calorie-restricted embryos. In Nrf2 knockout embryos, the induction of Nqo1 and Gsta1 genes was abrogated while that of Gsta4 was preserved, indicating an at least partially Nrf2-dependent induction of antioxidant genes after in utero calorie restriction. Measures of OS showed no difference (superoxide radical and malondialdehyde) or a small decrease (thiobarbituric reactive substances) in calorie-restricted WT embryos. Conclusions: Calorie restriction during pregnancy elicits the transcriptional induction of cytoprotective/antioxidant genes in the fetal liver, which is at least partially Nrf2-dependent, with a physiological significance that warrants further investigation.
C1 [Habeos, George I.; Filippopoulou, Fotini; Habeos, Evagelia E.; Lagoumintzis, George; Niarchos, Athanasios; Chartoumpekis, Dionysios V.] Univ Patras, Sch Med, Dept Internal Med, Div Endocrinol, Patras 26504, Greece.
   [Kalaitzopoulou, Electra; Skipitari, Marianna; Papadea, Polyxeni; Georgiou, Christos D.] Univ Patras, Dept Biol, Sect Genet Cell Biol & Dev, Patras 26504, Greece.
   [Lagoumintzis, George] Univ Patras, Dept Pharm, Patras 26504, Greece.
C3 University of Patras; University of Patras; University of Patras
RP Chartoumpekis, DV (corresponding author), Univ Patras, Sch Med, Dept Internal Med, Div Endocrinol, Patras 26504, Greece.
EM dchart@upatras.gr
RI Lagoumintzis, George/B-1913-2010; Skipitari, Marianna/GZG-7980-2022;
   Chartoumpekis, Dionysios/L-8071-2017; Georgiou, Christos/B-8354-2013
OI Habeos, George I/0000-0003-1232-3192; Kalaitzopoulou,
   Electra/0000-0002-7486-910X; Papadea, Polyxeni/0000-0002-5131-8196;
   Chartoumpekis, Dionysios/0000-0002-6139-6067; Lagoumintzis,
   George/0000-0002-0441-9023; Georgiou, Christos/0000-0001-9707-0109;
   Skipitari, Marianna/0000-0001-5077-1418
FU University of Patras; IKY (State Scholarships Foundation, Greece)
   Fellowship of excellence
FX This work was supported by internal funding managed by the University of
   Patras. A.N. was supported by an IKY (State Scholarships Foundation,
   Greece) Fellowship of excellence.
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   Zimmet P, 2018, NAT REV ENDOCRINOL, V14, P738, DOI 10.1038/s41574-018-0106-1
   Zisimopoulos DN, 2022, ARCH BIOCHEM BIOPHYS, V716, DOI 10.1016/j.abb.2021.109110
NR 67
TC 4
Z9 4
U1 1
U2 3
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD NOV
PY 2022
VL 11
IS 11
AR 2274
DI 10.3390/antiox11112274
PG 15
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA 6U9JX
UT WOS:000894677700001
PM 36421460
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Parikh, NI
   Gerschenson, M
   Bennett, K
   Gangcuangco, LMM
   Lopez, MS
   Mehta, NN
   Playford, MP
   Nakamoto, BK
   Seto, TB
   Chow, DC
   Shikuma, CM
AF Parikh, Nisha I.
   Gerschenson, Mariana
   Bennett, Kara
   Gangcuangco, Louie Mar M.
   Lopez, Mary S.
   Mehta, Nehal N.
   Playford, Martin P.
   Nakamoto, Beau K.
   Seto, Todd B.
   Chow, Dominic C.
   Shikuma, Cecilia M.
TI Lipoprotein concentration, particle number, size and cholesterol efflux
   capacity are associated with mitochondrial oxidative stress and function
   in an HIV positive cohort
SO ATHEROSCLEROSIS
LA English
DT Article
DE Atherosclerosis; Cardiovascular disease; Lipids; NMR spectroscopy;
   Oxidative phosphorylation; Cholesterol efflux capacity; HDL
ID HIGH-DENSITY-LIPOPROTEIN; INFLAMMATORY MARKERS; METABOLIC SYNDROME;
   DISEASE; HYPERCHOLESTEROLEMIA; PROFILES; RISK
AB Background: Association of lipoprotein particle size/number and HDL function with mitochondrial oxidative stress and function may underlie the excess cardiovascular (CVD) risk in HIV.
   Methods and results: Among HIV infected individuals on stable highly active antiretroviral therapy, we related standard and novel lipid measures [plasma total cholesterol, triglycerides, HDL-C, LDL-C, lipoprotein particle (-P) subclass size and number and HDL function (via cholesterol-efflux capacity)] with oxidative stress [peripheral blood mononuclear cell's mitochondrial-specific 8-oxo-deoxyguanine (8-oxo-dG)] and function markers [oxidative phosphorylation (OXPHOS) NADH dehydrogenase (Complex I) and cytochrome c oxidase (Complex IV) enzyme activities]. Multivariable-adjusted logistic and linear regression analyses were employed adjusting for age, gender, CD4 nadir, viral load, smoking, diabetes, HOMA-IR, hypertension and lipid medications. Among 150 HIV-infected persons (mean age 52 years, 12% women, median CD4 count 524 cell/mm3), low HDL-C and high total cholesterol/HDL-C ratio were related to PBMC 8-oxo-deoxyguanine (p = 0.01 and 0.02 respectively). Large HDL-P and HDL-P size were inversely related to PBMC 8-oxo-deoxyguanine (p = 0.04). Small LDL-P (p = 0.01) and total LDL-P (p = 0.01) were related to decreased OXPHOS Complex I activity. LDL-P was related to decreased OXPHOS Complex IV activity (p = 0.02). Cholesterol efflux capacity was associated with increased OXPHOS Complex IV activity.
   Conclusions: HDL concentration and particle size and number are related to decreased PBMC mitochondrial oxidative stress whereas HDL function is positively related to mitochondrial oxidative function. The association we find between atherogenic lipoprotein profile and increased oxidative stress and function suggests these pathways may be important in the pathogenesis of cardiometabolic disease in HIV disease. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
C1 [Parikh, Nisha I.; Bennett, Kara; Gangcuangco, Louie Mar M.; Nakamoto, Beau K.; Chow, Dominic C.; Shikuma, Cecilia M.] Univ Hawaii, John A Burns Sch Med, Dept Med, Hawaii Ctr AIDS, Honolulu, HI 96822 USA.
   [Parikh, Nisha I.] Univ Calif San Francisco, Div Cardiovasc, Dept Med, San Francisco, CA 94143 USA.
   [Gerschenson, Mariana; Lopez, Mary S.] Univ Hawaii, John A Burns Sch Med, Dept Cell & Mol Biol, Honolulu, HI 96822 USA.
   [Mehta, Nehal N.; Playford, Martin P.] NHLBI, Sect Inflammat & Cardiometabol Dis, NIH, Bethesda, MD 20892 USA.
   [Seto, Todd B.] Queens Med Ctr, Div Cardiovasc, Honolulu, HI USA.
   [Nakamoto, Beau K.] Straub Clin & Hosp, Dept Neurol, Honolulu, HI USA.
C3 University of Hawaii System; University of California System; University
   of California San Francisco; University of Hawaii System; National
   Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood
   Institute (NHLBI); The Queen's Medical Center
RP Parikh, NI (corresponding author), Univ Calif San Francisco, Div Cardiovasc, Dept Med, San Francisco, CA 94143 USA.
EM nparikh@medicine.uscf.edu
RI Gangcuangco, Louie/P-9579-2019; Lopez, Mary/U-6172-2019; Mehta,
   Nehal/W-4669-2019
OI Gangcuangco, Louie Mar/0000-0002-6714-9294; Chow,
   Dominic/0000-0001-7395-038X; Gerschenson, Mariana/0000-0002-8615-5964
FU NIH [U54RR026136, U54MD007584, R01HL095135, K23 HL088981, P20MD000173,
   G12MD007601, P30103341]
FX This work was supported by NIH grants U54RR026136, U54MD007584,
   R01HL095135 (CMS), K23 HL088981 (DC), P20MD000173, G12MD007601,
   P30103341 (MG).
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NR 23
TC 20
Z9 24
U1 0
U2 12
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0021-9150
EI 1879-1484
J9 ATHEROSCLEROSIS
JI Atherosclerosis
PD MAR
PY 2015
VL 239
IS 1
BP 50
EP 54
DI 10.1016/j.atherosclerosis.2014.12.005
PG 5
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA CB6RH
UT WOS:000349753800008
PM 25574857
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Kotani, K
   Yamada, T
AF Kotani, Kazuhiko
   Yamada, Toshiyuki
TI Association between urinary 8-OHdG and pulse wave velocity in
   hypertensive patients with type 2 diabetes mellitus
SO SINGAPORE MEDICAL JOURNAL
LA English
DT Article
DE arterial stiffness; atherosclerosis; DNA damage; oxidative stress; pulse
   wave velocity
ID OXIDATIVE DNA-DAMAGE; ANKLE VASCULAR INDEX; CARDIOVASCULAR RISK-FACTORS;
   CALCIUM-CHANNEL BLOCKER; ARTERIAL STIFFNESS; METABOLIC SYNDROME;
   BLOOD-PRESSURE; STRESS; IMPACT; ATHEROSCLEROSIS
AB INTRODUCTION Oxidative stress, assessed using 8-hydroxy-2'-deoxyguanosine (8-OHdG), can be associated with arterial stiffness in patients with type 2 diabetes mellitus (T2DM) and/or hypertension (HT). We investigated the correlation between urinary 8-OHdG and pulse wave velocity (PWV) in hypertensive and non-hypertensive T2DM patients with fair glycaemic control to determine the clinical significance of HT as a comorbidity in the diabetic state.
   METHODS Clinical data, including traditional cardiovascular risk factors, diabetic complications, prescribed agents, urinary 8-OHdG level and brachial-ankle PWV, was collected from T2DM patients with and without HT.
   RESULTS There were 76 patients (45 men, 31 women; mean age 61 years; mean haemoglobin A1c level 6.5%) in the study cohort. T2DM patients with HT had significantly higher mean PWV than patients without HT (1,597 cm/s vs 1,442 cm/s; p < 0.05). Patients with HT showed no significant difference in 8-OHdG levels relative to those without HT (median 7.9 ng/mg creatinine vs 8.8 ng/mg creatinine; p > 0.05). Simple linear correlation and stepwise multiple linear regression analyses revealed that 8-OHdG levels correlated independently, significantly and positively with PWV among T2DM patients with HT (r = 0.33, p < 0.05; beta = 0.23, p < 0.05). No significant correlation was observed between 8-OHdG levels and PWV among T2DM patients without HT.
   CONCLUSION In the hypertensive state, oxidative stress can be responsible for the development of arterial stiffness, even in patients with fairly well controlled T2DM. Oxidative stress management may be necessary for the prevention of cardiovascular disease in this population.
C1 [Kotani, Kazuhiko; Yamada, Toshiyuki] Jichi Med Univ, Dept Clin Lab Med, Shimotsuke, Tochigi 3290498, Japan.
C3 Jichi Medical University
RP Kotani, K (corresponding author), Jichi Med Univ, Dept Clin Lab Med, 3311-1 Yakushiji, Shimotsuke, Tochigi 3290498, Japan.
EM kazukotani@jichi.ac.jp
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NR 50
TC 13
Z9 15
U1 0
U2 1
PU SINGAPORE MEDICAL ASSOC
PI SINGAPORE
PA 2985 JALAN BUKIT MERAH, #02-2C, SMF BUILDING, SINGAPORE, SINGAPORE
SN 0037-5675
J9 SINGAP MED J
JI Singap. Med. J.
PD APR
PY 2014
VL 55
IS 4
BP 202
EP 208
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA AF2WX
UT WOS:000334574300011
PM 24763836
DA 2025-06-11
ER

PT J
AU Park, SH
   Seo, W
   Xu, MJ
   Mackowiak, B
   Lin, YH
   He, Y
   Fu, YJ
   Hwang, S
   Kim, SJ
   Guan, YK
   Feng, DC
   Yu, LQ
   Lehner, R
   Liangpunsakul, S
   Gao, B
AF Park, Seol Hee
   Seo, Wonhyo
   Xu, Ming-Jiang
   Mackowiak, Bryan
   Lin, Yuhong
   He, Yong
   Fu, Yaojie
   Hwang, Seonghwan
   Kim, Seung-Jin
   Guan, Yukun
   Feng, Dechun
   Yu, Liqing
   Lehner, Richard
   Liangpunsakul, Suthat
   Gao, Bin
TI Ethanol and its Nonoxidative Metabolites Promote Acute Liver Injury by
   Inducing ER Stress, Adipocyte Death, and Lipolysis
SO CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
LA English
DT Article
DE Binge; ADH; ALDH; FAEE; Carboxylesterase 1d
ID ACID ETHYL-ESTERS; ADIPOSE-TISSUE; BINGE DRINKING; ALCOHOL INTAKE;
   DISEASE; MICE; RISK; PATHWAYS; FIBROSIS; SYNTHASE
AB BACKGROUND & AIMS: Binge drinking in patients with metabolic syndrome accelerates the development of alcohol-associated liver disease. However, the underlying mechanisms remain elusive. We investigated if oxidative and nonoxidative alcohol metabolism pathways, diet-induced obesity, and adi-pose tissues influenced the development of acute liver injury in a single ethanol binge model. METHODS: A single ethanol binge was administered to chow-fed or high-fat diet (HFD)-fed wild-type and genetically modified mice.RESULTS: Oral administration of a single dose of ethanol induced acute liver injury and hepatic endoplasmic reticu-lum (ER) stress in chow-or HFD-fed mice. Disruption of the Adh1 gene increased blood ethanol concentration and exacerbated acute ethanol-induced ER stress and liver injury in both chow-fed and HFD-fed mice, while disruption of the Aldh2 gene did not affect such hepatic injury despite high blood acetaldehyde levels. Mechanistic studies showed that alcohol, not acetaldehyde, promoted hepatic ER stress, fatty acid synthesis, and increased adipocyte death and lipolysis, contributing to acute liver injury. Increased serum fatty acid ethyl esters (FAEEs), which are formed by an enzyme-mediated esterification of ethanol with fatty acids, were detected in mice after ethanol gavage, with higher levels in Adh1 knockout mice than in wild-type mice. Deletion of the Ces1d gene in mice markedly reduced the acute ethanol-induced increase of blood FAEE levels with a slight but significant reduction of serum aminotransferase levels.CONCLUSIONS: Ethanol and its nonoxidative metabolites, FAEEs, not acetaldehyde, promoted acute alcohol-induced liver injury by inducing ER stress, adipocyte death, and lipolysis. (Cell Mol Gastroenterol Hepatol 2023;15:281-306; https:// doi.org/10.1016/j.jcmgh.2022.10.002)
C1 [Park, Seol Hee; Seo, Wonhyo; Xu, Ming-Jiang; Mackowiak, Bryan; Lin, Yuhong; He, Yong; Fu, Yaojie; Hwang, Seonghwan; Kim, Seung-Jin; Guan, Yukun; Feng, Dechun; Gao, Bin] NIAAA, Lab Liver Dis, NIH, Bethesda, MD USA.
   [Seo, Wonhyo] Ewha Womans Univ, Coll Pharm, Lab Hepatotox, Seoul, South Korea.
   [Yu, Liqing] Univ Maryland, Dept Med, Sch Med, Baltimore, MD USA.
   [Lehner, Richard] Univ Alberta, Dept Cell Biol, Grp Mol & Cell Biol Lipids, Edmonton, AB, Canada.
   [Lehner, Richard] Univ Alberta, Dept Pediat, Grp Mol & Cell Biol Lipids, Edmonton, AB, Canada.
   [Liangpunsakul, Suthat] Indiana Univ Sch Med, Dept Med, Div Gastroenterol & Hepatol, Indianapolis, IN USA.
   [Liangpunsakul, Suthat] Indiana Univ Sch Med, Dept Biochem & Mol Biol, Indianapolis, IN USA.
   [Liangpunsakul, Suthat] Richard L Roudebush Vet Adm Med Ctr, Indianapolis, IN USA.
   [Gao, Bin] Univ Alberta, Dept Pediat, Grp Mol & Cell Biol Lipids, Edmonton, AB, Canada.
C3 National Institutes of Health (NIH) - USA; NIH National Institute on
   Alcohol Abuse & Alcoholism (NIAAA); Ewha Womans University; University
   System of Maryland; University of Maryland Baltimore; University of
   Alberta; University of Alberta; Indiana University System; Indiana
   University Bloomington; Indiana University System; Indiana University
   Bloomington; US Department of Veterans Affairs; Veterans Health
   Administration (VHA); Richard L. Roudebush VA Medical Center; University
   of Alberta
RP Gao, B (corresponding author), Univ Alberta, Dept Pediat, Grp Mol & Cell Biol Lipids, Edmonton, AB, Canada.
EM bgao@mail.nih.gov
RI Feng, Dechun/Q-5962-2016; Wang, Xiaolin/ADQ-6971-2022; Yin,
   Shi/GPX-3723-2022; Mackowiak, Bryan/GQA-5323-2022; gao,
   bin/JYW-5418-2024
OI He, Yong/0009-0006-8681-5287
FU National Institute on Alcohol Abuse and Alcoholism, National Institutes
   of Health; National Research Foundation of Korea [2018R1A5A2025286,
   2022R1C1C1008912]
FX This work was supported by the intramural program of the National
   Institute on Alcohol Abuse and Alcoholism, National Institutes of Health
   (B.G.) . Seol Hee Park and Wonhyo Seo were supported in part by the
   National Research Foundation of Korea fellowships (2018R1A5A2025286 and
   2022R1C1C1008912) when they were at the National Institute on Alcohol
   Abuse and Alcoholism.
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NR 48
TC 43
Z9 44
U1 10
U2 30
PU ELSEVIER INC
PI SAN DIEGO
PA 525 B STREET, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 2352-345X
J9 CELL MOL GASTROENTER
JI Cell. Mol. Gastroenterol. Hepatol.
PY 2023
VL 15
IS 2
BP 281
EP 306
DI 10.1016/j.jcmgh.2022.10.002
EA DEC 2022
PG 26
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 7M0HM
UT WOS:000906338100001
PM 36243320
OA Green Published
DA 2025-06-11
ER

PT J
AU Salazar, AM
   Sordo, M
   Navarrete-Monroy, E
   Pánico, P
   Díaz-Villaseñor, A
   Montúfar-Chaveznava, R
   Caldelas, I
   Ostrosky-Wegman, P
AF Salazar, Ana Maria
   Sordo, Monserrat
   Navarrete-Monroy, Erika
   Panico, Pablo
   Diaz-Villasenor, Andrea
   Montufar-Chaveznava, Rodrigo
   Caldelas, Ivette
   Ostrosky-Wegman, Patricia
TI Maternal overnutrition before and during pregnancy induces DNA damage in
   male offspring: A rabbit model
SO MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
LA English
DT Article
DE Offspring; High-fat diet; DNA damage; Micronuclei; Oxidative stress
ID METABOLIC SYNDROME; PERIPHERAL-BLOOD; BONE-MARROW; FREQUENCY; MICE;
   ERYTHROCYTES; EXPOSURE; OBESITY; RISK; AGE
AB Using a rabbit model, we investigated whether maternal intake of a high-fat and high-carbohydrate diet (HFCD) before and during pregnancy induces an increase in micronuclei frequency and oxidative stress in offspring during adulthood. Female rabbits received a standard diet (SD) or HFCD for two months before mating and during gestation. The offspring from both groups were nursed by foster mothers fed SD until postnatal day 35. After weaning, all the animals received SD until postnatal day 440. At postnatal day 370, the frequency of micronuclei in peripheral blood reticulocytes (MN-RETs) increased in the male offspring from HFCD-fed mothers compared with the male offspring from SD-fed mothers. Additionally, fasting serum glucose increased in the offspring from HFCD-fed mothers compared with the offspring from SD-fed mothers. At postnatal day 440, the offspring rabbits were challenged with HFCD or continued with SD for 30 days. There was an increase in MN-RET frequency in the male rabbits from HFCD-fed mothers, independent of the type of challenging diet consumed during adulthood. The challenge induced changes in serum cholesterol, LDL and HDL that were influenced by the maternal diet and offspring sex. We measured malondialdehyde in the liver of rabbits as an oxidative stress marker after diet challenge. Oxidative stress in the liver only increased in the female offspring from HFCD-fed mothers who were also challenged with this same diet. The data indicate that maternal overnutrition before and during pregnancy is able to promote different effects depending on the sex of the animals, with chromosomal instability in male offspring and oxidative stress and hypercholesterolemia in female offspring. Our data might be important in the understanding of chronic diseases that develop in adulthood due to in utero exposure to maternal diet.
C1 [Salazar, Ana Maria; Sordo, Monserrat; Panico, Pablo; Diaz-Villasenor, Andrea; Ostrosky-Wegman, Patricia] Univ Nacl Autonoma Mexico, Inst Invest Biomed, Dept Med Genom & Toxicol Ambiental, Mexico City 04510, DF, Mexico.
   [Navarrete-Monroy, Erika; Caldelas, Ivette] Univ Nacl Autonoma Mexico, Inst Invest Biomed, Dept Fisiol & Biol Celular, Mexico City, DF, Mexico.
   [Montufar-Chaveznava, Rodrigo] Univ Nacl Autonoma Mexico, Fac Ingn, Mexico City, DF, Mexico.
C3 Universidad Nacional Autonoma de Mexico; Universidad Nacional Autonoma
   de Mexico; Universidad Nacional Autonoma de Mexico
RP Ostrosky-Wegman, P (corresponding author), Univ Nacl Autonoma Mexico, Inst Invest Biomed, Dept Med Genom & Toxicol Ambiental, Mexico City 04510, DF, Mexico.
EM ostrosky@biomedicas.unam.mx
RI Montufar-Chaveznava, Rodrigo/A-5076-2015
OI Montufar-Chaveznava, Rodrigo/0000-0001-7630-6207; Diaz-Villasenor,
   Andrea/0000-0003-1222-2615; Panico, Pablo/0000-0002-9669-4224
FU PAPIIT-UNAM [IN201914, IN212516]; Programa Institucional de Estrategias
   de Prevencion en Obesidad y Diabetes del Instituto de Investigaciones
   Biomedicas-UNAM; CONACYT Fronteras de la Ciencia [398]
FX This work was supported by PAPIIT-UNAM (grants IN201914 and IN212516),
   Programa Institucional de Estrategias de Prevencion en Obesidad y
   Diabetes del Instituto de Investigaciones Biomedicas-UNAM and CONACYT
   Fronteras de la Ciencia (grant 398). We acknowledge the technical
   assistance of Georgina Diaz-Herrera, Pamela E. Vega-Ruiz and Yosette
   Barb.
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NR 33
TC 6
Z9 6
U1 0
U2 8
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1383-5718
EI 1879-3592
J9 MUTAT RES-GEN TOX EN
JI Mutat. Res. Genet. Toxicol. Environ. Mutagen.
PD MAY
PY 2021
VL 865
AR 503324
DI 10.1016/j.mrgentox.2021.503324
EA FEB 2021
PG 8
WC Biotechnology & Applied Microbiology; Genetics & Heredity; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Genetics & Heredity; Toxicology
GA RO9ZP
UT WOS:000641397400002
PM 33865538
DA 2025-06-11
ER

PT J
AU Khound, P
   Gurumayum, N
   Barge, SR
   Sarma, PP
   Devi, R
AF Khound, Puspanjali
   Gurumayum, Nonibala
   Barge, Sagar Ramrao
   Sarma, Partha Pratim
   Devi, Rajlakshmi
TI Phenylethanoid glycoside-enriched fraction of Clerodendrum
   glandulosum ameliorates oxidative stress and mitochondrial
   dysfunction via PGC1α/TFAM upregulation
SO 3 BIOTECH
LA English
DT Article
DE Clerodendrum glandulosum; Glycolysis; Mitochondrial
   dysfunction; Oxidative stress; Verbascoside
ID ANTIOXIDANT ACTIVITY; COLEBROOKIANUM WALP; IN-VITRO; CONSTITUENTS;
   VERBASCOSIDE; PALMITATE; EXTRACTS; LEAVES; CELLS
AB Clerodendrum glandulosum is utilized as a soup or vegetable in Northeast India and has been reported to exhibit a range of medicinal and pharmacological properties. Its use in traditional cuisine and medicine highlights its potential importance in both dietary and therapeutic applications. This study focuses on the bioactive potential of the ethyl acetate fraction (EAF) derived from the hydro-alcoholic extract of C. glandulosum leaves against palmitate-induced oxidative stress and mitochondrial dysfunction. The EAF exhibited significant radical scavenging activities, with IC50 values of 29.56 mu g/mL (ABTS inhibition) and 36.61 mu g/mL (DPPH inhibition). Additionally, EAF demonstrated strong anti-glycation properties, effectively reducing fructosamine levels and protein carbonylation while increasing total thiol content. Phytochemical analysis revealed the presence of several bioactive compounds--namely verbascoside, isoverbascoside, and ferulic acid--associated with potential biological activities. Chromatographic analysis showed that verbascoside is the primary compound, with a concentration of 240.41 +/- 8.62 mu g/mg. Furthermore, EAF pretreatment significantly lowered the levels of reactive oxygen species, DNA damage, and lactate dehydrogenase release in palmitate-induced cells. During extracellular flux analysis for mitochondrial and glycolysis stress tests, EAF treatment demonstrated effective recovery of mitochondrial respiration and ATP production in palmitate-induced cells. EAF also upregulated essential mitochondrial markers, including peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1 alpha) and mitochondrial transcription factor A (TFAM), which enhanced mitochondrial biogenesis and function. Overall, our study underscores the potential of the EAF from Clerodendrum glandulosum as a therapeutic agent to mitigate oxidative stress and mitochondrial dysfunction. This study suggests the efficacy of the active compounds for further development of phytopharmaceutical interventions for metabolic syndrome and related disorders.
C1 [Khound, Puspanjali; Gurumayum, Nonibala; Barge, Sagar Ramrao; Sarma, Partha Pratim; Devi, Rajlakshmi] Inst Adv Study Sci & Technol, Life Sci Div, Gauhati 781035, India.
   [Khound, Puspanjali; Gurumayum, Nonibala; Devi, Rajlakshmi] Gauhati Univ, Dept Zool, Gauhati 781014, India.
   [Barge, Sagar Ramrao] Beth Israel Deaconess Med Ctr, Dept Med, Boston, MA 02215 USA.
   [Barge, Sagar Ramrao] Harvard Med Sch, Boston, MA 02215 USA.
C3 Department of Science & Technology (India); Institute of Advanced Study
   in Science & Technology (IASST); Gauhati University; Harvard University;
   Harvard University Medical Affiliates; Beth Israel Deaconess Medical
   Center; Harvard University; Harvard Medical School
RP Devi, R (corresponding author), Inst Adv Study Sci & Technol, Life Sci Div, Gauhati 781035, India.; Devi, R (corresponding author), Gauhati Univ, Dept Zool, Gauhati 781014, India.
EM rajiasst@gmail.com
RI Barge, Sagar/ABB-9617-2021; Sarma, Partha/HKV-4592-2023
FU In-house Project IASST [IASST/R&D/ICP/IHP-19/2023-24/1301-1310];
   Institute of Advanced Study in Science and Technology
   [45/04/2022/TRM/BMS]; Indian Council of Medical Research; Department of
   Science and Technology, Government of India
FX This work has been supported by the In-house core-funded research
   project (No. IASST/R&D/ICP/IHP-19/2023-24/1301-1310) of the Institute of
   Advanced Study in Science and Technology. The authors sincerely
   acknowledge the Indian Council of Medical Research for the ICMR-SRF
   Fellowship granted to Ms. Puspanjali Khound (No. 45/04/2022/TRM/BMS),
   Sophisticated Analytical Instrument Centre, IASST, and the Department of
   Science and Technology, Government of India, for providing the necessary
   support.
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NR 40
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 2190-572X
EI 2190-5738
J9 3 BIOTECH
JI 3 Biotech
PD APR
PY 2025
VL 15
IS 4
AR 85
DI 10.1007/s13205-025-04235-3
PG 15
WC Biotechnology & Applied Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology
GA Z9B6Z
UT WOS:001441777600001
PM 40084243
DA 2025-06-11
ER

PT J
AU Bansal, P
   Bhandari, U
   Ahmad, S
AF Bansal, Priyanka
   Bhandari, Uma
   Ahmad, Sayeed
TI Embelin from Embelia ribes Ameliorates Oxidative Stress and
   Inflammation in High-Fat Diet-Fed Obese C57BL/6 Mice
SO PHARMACOGNOSY MAGAZINE
LA English
DT Article
DE Embelin; high-fat diet; nuclear factor erythroid 2-related factor;
   nuclear factor kappa-B; obesity; oxidative stress
ID METABOLIC SYNDROME; ANTIOXIDANT; ASSOCIATION; ACTIVATION; EXTRACT; NRF2
AB Background: A safe, efficacious, and economical drug for the treatment of obesity is the need of the time. Literature published in previous years referred to embelin as a potential investigational therapeutic agent to manage obesity. Objectives: This study was designed to isolate and characterize embelin from Embelia ribes and further to assess its role in alleviating oxidative stress and chronic inflammation in the high-fat diet (HFD) fed obese C57BL/6 mice. Materials and Methods: Embelin extracted from berries of E. ribes with n-hexane by soxhlet extraction was characterized using high-performance thin-layer chromatography, infrared and liquid chromatography-mass spectrometry analyses. The obesity was induced by feeding of HFD for 8 weeks. Embelin (50 mg/kg/day, p.o.) was administered from 5th to 8th weeks along with HFD. After 8 weeks, the body weight gain and body mass index were calculated. Then, animals were sacrificed; serum and tissues were collected to further assess the various biomarkers of oxidative stress and inflammation. Results: The presence of embelin was confirmed using the above-mentioned analytical techniques. Treatment with Embelin showed amelioration of obesity biomarkers along with the substantial decline in levels of protein expression of nuclear factor erythroid 2-related factor and nuclear factor kappa-B in liver tissue. Treatment with embelin also normalizes the liver tissue levels of thiobarbituric acid reactive substances, glutathione, superoxide dismutase, and catalase. The histopathological analysis of liver tissue showed significant prevention of necrotic and inflammatory changes in embelin treated HFD fed mice. Conclusion: The results of the study clearly indicated the potential of embelin in ameliorating obesity by alleviating oxidative stress and inflammation induced by HFD in C57BL/6 mice.
C1 [Bansal, Priyanka; Bhandari, Uma] Jamia Hamdard, Sch Pharmaceut Educ & Res, Dept Pharmacol, New Delhi, India.
   [Ahmad, Sayeed] Jamia Hamdard, Sch Pharmaceut Educ & Res, Dept Pharmacognosy & Phytochem, New Delhi, India.
C3 Jamia Hamdard University; Jamia Hamdard University
RP Bhandari, U (corresponding author), Jamia Hamdard, Sch Pharmaceut Educ & Res, Dept Pharmacol, New Delhi, India.
EM uma_bora@hotmail.com
RI Bhandari, Uma/GPX-1103-2022; Ahmad, Sayeed/N-1359-2013; bansal,
   priyanka/LIG-2903-2024
FU Indian Council of Medical Research (ICMR) [45/28/2019-PHA/BMS]
FX This research work has been financially supported by a grant from the
   Indian Council of Medical Research (ICMR) (No. 45/28/2019-PHA/BMS).
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NR 36
TC 4
Z9 4
U1 0
U2 4
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, Maharashtra, INDIA
SN 0973-1296
EI 0976-4062
J9 PHARMACOGN MAG
JI Pharmacogn. Mag.
PD JUL-SEP
PY 2020
VL 16
IS 5
SU 3
BP S443
EP S449
DI 10.4103/pm.pm_77_20
PG 7
WC Chemistry, Medicinal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA QI2NR
UT WOS:000618812000001
DA 2025-06-11
ER

PT J
AU Padbury, JF
   Do, BT
   Bann, CM
   Marsit, C
   Hintz, SR
   Vohr, BR
   Lowe, J
   Newman, JE
   Granger, DA
   Payne, A
   Watterberg, K
AF Padbury, James F.
   Do, Barbara T.
   Bann, Carla M.
   Marsit, Carmen
   Hintz, Susan R.
   Vohr, Betty R.
   Lowe, Jean
   Newman, Jamie E.
   Granger, Douglas A.
   Payne, Allison
   Watterberg, Kristi
CA Eunice Kennedy Shriver Natl Inst
TI DNA methylation in former extremely low birth weight newborns:
   association with cardiovascular and endocrine function
SO PEDIATRIC RESEARCH
LA English
DT Article
ID LONG-TERM CONSEQUENCES; MATERNAL DEPRESSION; INFANT GROWTH; FETAL;
   NR3C1; PLACENTA
AB Background There is increased risk of cardiovascular, metabolic, and hypertensive disorders in later life in the preterm population. We studied school-age children who had been born extremely premature who had undergone endocrine, cardiovascular, and anthropometric evaluations. Methods School age measurements of salivary cortisol, adrenal androgens, blood pressure, and anthropometric markers were correlated with DNA methylation of 11-betahydroxysteroid dehydrogenase type 2 (11BHSD2), leptin, and the LINE1 repetitive DNA element. Results We observed a modest correlation between log AUC for salivary cortisol and methylation of leptin in preterm infants and a negative correlation between methylation of region 1 of the glucocorticoid receptor (GR in term-born infants. There was an association between LINE1 methylation and cortisol response to awakening and a negative correlation between LINE1 and systolic blood pressure at 6-7 years. Methylation of the GR promoter region showed a positive association with systolic blood pressure at 6-7 years of age. Conclusions These results show that extremely preterm birth, followed by complex patterns of endocrine, cardiovascular, and metabolic exposures during early postnatal life, is associated with lasting changes in DNA methylation patterns in genes involved in hypothalamic pituitary adrenal axis function, adrenal hormonal regulation, and cardiometabolic risk. Impact
   Preterm infants have significant environmental and physiological exposures during early life that may have lasting impact on later function. Alterations in hypothalamic pituitary adrenal axis (HPA) function have been associated with these exposures. We examined the associated changes in DNA methylation of important genes involved in HPA function, metabolism, and global DNA methylation. The changes we saw in DNA methylation may help to explain associated cardiovascular, metabolic, and growth disturbance in these children in later life.
C1 [Padbury, James F.; Vohr, Betty R.] Brown Univ, Women & Infants Hosp, Dept Pediat, Providence, RI 02908 USA.
   [Do, Barbara T.; Bann, Carla M.; Newman, Jamie E.] RTI Int, Social Stat & Environm Sci Unit, Res Triangle Pk, NC USA.
   [Marsit, Carmen] Emory Univ, Rollins Sch Publ Hlth, Dept Environm Hlth, Atlanta, GA 30322 USA.
   [Hintz, Susan R.] Stanford Univ, Sch Med, Dept Pediat, Div Neonatal & Dev Med, Palo Alto, CA 94304 USA.
   [Hintz, Susan R.] Lucile Packard Childrens Hosp, Palo Alto, CA USA.
   [Lowe, Jean; Watterberg, Kristi] Univ New Mexico, Hlth Sci Ctr, Albuquerque, NM 87131 USA.
   [Granger, Douglas A.] Univ Calif Irvine, Inst Interdisciplinary Salivary Biosci Res, Irvine, CA USA.
   [Granger, Douglas A.] Johns Hopkins Univ, Sch Med, Bloomberg Sch Publ Hlth, Baltimore, MD USA.
   [Granger, Douglas A.] Johns Hopkins Univ, Sch Nursing, Baltimore, MD USA.
   Case Western Reserve Univ, Rainbow Babies & Childrens Hosp, Dept Pediat, Cleveland, OH 44106 USA.
C3 Brown University; Women & Infants Hospital Rhode Island; Research
   Triangle Institute; Emory University; Rollins School Public Health;
   Stanford University; Lucile Packard Children's Hospital (LPCH);
   University of New Mexico's Health Sciences Center; University of New
   Mexico; University of California System; University of California
   Irvine; Johns Hopkins University; Johns Hopkins Bloomberg School of
   Public Health; Johns Hopkins University; University System of Ohio; Case
   Western Reserve University; Case Western Reserve University Hospital;
   University Hospitals of Cleveland; Rainbow Babies & Children's Hospital
RP Padbury, JF (corresponding author), Brown Univ, Women & Infants Hosp, Dept Pediat, Providence, RI 02908 USA.
EM james_padbury@brown.edu
OI Marsit, Carmen/0000-0003-4566-150X; Bann, Carla/0000-0001-9305-8305;
   Hintz, Susan/0000-0001-7023-4433; Payne, Allison/0000-0003-0216-6269;
   Bell, Edward/0000-0002-5568-0889; Ambalavanan,
   Namasivayam/0000-0003-0731-9092; Newman, Jamie/0000-0001-8880-8132; Do,
   Barbara T./0000-0002-6012-1168
FU National Institutes of Health; Eunice Kennedy Shriver National Institute
   of Child Health and Human Development (NICHD); National Heart, Lung, and
   Blood Institute (NHLBI); NHLBI [R01HL117764]; National Institutes of
   Health Institute for General Medical Sciences [P30GM114750, P20RR18728,
   P30GM103410]; Eunice Kennedy Shriver National Institute of Child Health
   and Human Development [UG1HD087229] Funding Source: NIH RePORTER;
   National Institute of Neurological Disorders and Stroke; Eunice Kennedy
   Shriver National Institute of Child Health and Human Development
   [U24HD095254] Funding Source: NIH RePORTER
FX The National Institutes of Health, the Eunice Kennedy Shriver National
   Institute of Child Health and Human Development (NICHD), and the
   National Heart, Lung, and Blood Institute (NHLBI) provided grant support
   for the Neonatal Research Network's Extended Follow-up at School Age for
   the SUPPORT Neuroimaging and Neurodevelopmental Outcomes (NEURO) Cohort
   through cooperative agreements. NHLBI provided support for this study
   (R01HL117764). Analytical work on pyrosequencing was carried out in the
   core research facilities supported by awards from the National
   Institutes of Health Institute for General Medical Sciences awards
   P30GM114750, P20RR18728, and P30GM103410. While NICHD staff had input
   into the study design, conduct, analysis, and manuscript drafting, the
   comments and views of the authors do not necessarily represent the views
   of the NICHD.
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NR 34
TC 6
Z9 7
U1 0
U2 4
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0031-3998
EI 1530-0447
J9 PEDIATR RES
JI Pediatr. Res.
PD MAY
PY 2022
VL 91
IS 6
BP 1469
EP 1477
DI 10.1038/s41390-021-01531-5
EA MAY 2021
PG 9
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA 3Q1BU
UT WOS:000647497900001
PM 33953357
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Huang, YT
   Steptoe, A
   Zaninotto, P
AF Huang, Yun-Ting
   Steptoe, Andrew
   Zaninotto, Paola
TI Prevalence of Undiagnosed Diabetes in 2004 and 2012: Evidence From the
   English Longitudinal Study of Aging
SO JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL
   SCIENCES
LA English
DT Article
DE Diabetes unawareness; England; Prevalence; Risk factor
ID OLDER-ADULTS; MELLITUS; HEALTH; DEPRESSION; RISK; STATES
AB Background: In light of recent publicity campaigns to raise awareness of diabetes, we investigated changes in the prevalence of diabetes and undiagnosed diabetes in adults age 50 and older in England between 2004 and 2012, and explored risk factors for undiagnosed diabetes.
   Method: In total, 7666 and 7729 individuals were from Wave 2 (2004-2005, mean age 66.6) and Wave 6 (2012-2013, mean age 67.6) of the English Longitudinal Study of Ageing. Diagnosed diabetes was defined as either self-reported diabetes or taking diabetic medications. Undiagnosed diabetes was defined as not self-reporting diabetes and not taking diabetic medications, but having a glycated hemoglobin measurement >= 48 mmol/mol (6.5%).
   Results: There were increases in both diagnosed diabetes (7.7%-11.5%) and undiagnosed diabetes (2.4%-3.4%) between 2004 and 2012. However, a small decrease in the proportion of people with diabetes who were unaware of this condition (24.5%-23.1%, p < .05) was observed. Only men aged 50-74 showed a stable prevalence of undiagnosed diabetes, with better recognition of diabetes. Age, non-white ethnicity, manual social class, higher diastolic blood pressure, and cholesterol level were factors associated with higher risks of undiagnosed diabetes, whereas greater depressive symptoms were related to lower risks.
   Conclusion: This study suggests that the greater awareness of diabetes in the population of England has not resulted in a decline in undiagnosed cases between 2004 and 2012. A greater focus on people from lower socioeconomic groups and those with cardiometabolic risk factors may help early diagnosis of diabetes for older adults.
C1 [Huang, Yun-Ting; Zaninotto, Paola] UCL, Dept Epidemiol & Publ Hlth, 1-19 Torrington Pl, London WC1E 7HB, England.
   [Steptoe, Andrew] UCL, Dept Behav Sci & Hlth, London, England.
C3 University of London; University College London; University of London;
   University College London
RP Huang, YT (corresponding author), UCL, Dept Epidemiol & Publ Hlth, 1-19 Torrington Pl, London WC1E 7HB, England.
EM yun-ting.huang@ucl.ac.uk
RI Steptoe, Andrew/Y-2440-2019
OI Huang, Yun-Ting/0000-0001-7017-9198; Zaninotto,
   Paola/0000-0003-3036-0499
FU National Institute of Aging [R01AG017644]
FX Funding is provided by National Institute of Aging (R01AG017644) and by
   a consortium of UK government departments coordinated by the National
   Institute for Health Research. The funders had no role in the analysis
   or interpretation of data, the writing of this article, or the decision
   to submit the article for publication.
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NR 42
TC 8
Z9 8
U1 1
U2 3
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1079-5006
EI 1758-535X
J9 J GERONTOL A-BIOL
JI J. Gerontol. Ser. A-Biol. Sci. Med. Sci.
PD MAY
PY 2021
VL 76
IS 5
BP 922
EP 928
DI 10.1093/gerona/glaa179
PG 7
WC Geriatrics & Gerontology; Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA SK4XZ
UT WOS:000656221600023
PM 32674123
OA Green Published
DA 2025-06-11
ER

PT J
AU Puglisi, S
   Perini, AME
   Botto, C
   Oliva, F
   Terzolo, M
AF Puglisi, Soraya
   Perini, Anna Maria Elena
   Botto, Cristina
   Oliva, Francesco
   Terzolo, Massimo
TI Long-Term Consequences of Cushing Syndrome: A Systematic Literature
   Review
SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Review
DE hypercortisolism; comorbidities; hypertension; diabetes; osteoporosis;
   myopathy; thromboembolism; depression; cognitive impairment; mortality
ID QUALITY-OF-LIFE; COGNITIVE IMPAIRMENTS; INCREASED PREVALENCE;
   PERSONALITY-TRAITS; BONE MASS; FOLLOW-UP; DISEASE; REMISSION; MORTALITY;
   CURE
AB It is held that the condition of endogenous chronic hypersecretion of cortisol (Cushing syndrome, CS), causes several comorbidities, including cardiovascular and metabolic disorders, musculoskeletal alterations, as well as cognitive and mood impairment. Therefore, CS has an adverse impact on the quality of life and life expectancy of affected patients. What remains unclear is whether disease remission may induce a normalization of the associated comorbid conditions. In order to retrieve updated information on this issue, we conducted a systematic search using the Pubmed and Embase databases to identify scientific papers published from January 1, 2000, to December 31, 2022. The initial search identified 1907 potentially eligible records. Papers were screened for eligibility and a total of 79 were included and classified by the main topic (cardiometabolic risk, thromboembolic disease, bone impairment, muscle damage, mood disturbances and quality of life, cognitive impairment, and mortality).
   Although the limited patient numbers in many studies preclude definitive conclusions, most recent evidence supports the persistence of increased morbidity and mortality even after long-term remission. It is conceivable that the degree of normalization of the associated comorbid conditions depends on individual factors and characteristics of the conditions. These findings highlight the need for early recognition and effective management of patients with CS, which should include active treatment of the related comorbid conditions. In addition, it is important to maintain a surveillance strategy in all patients with CS, even many years after disease remission, and to actively pursue specific treatment of comorbid conditions beyond cortisol normalization.
C1 [Puglisi, Soraya; Perini, Anna Maria Elena; Botto, Cristina; Terzolo, Massimo] Univ Turin, San Luigi Hosp, Dept Clin & Biol Sci, Internal Med, Regione Gonzole 10, I-10043 Orbassano, Italy.
   [Oliva, Francesco] Univ Turin, Univ Hosp Citta Salute & Sci Torino, Dept Clin & Biol Sci, Clin Psychol Unit, I-10126 Turin, Italy.
C3 University of Turin; A.O.U. Citta della Salute e della Scienza di
   Torino; University of Turin
RP Terzolo, M (corresponding author), Univ Turin, San Luigi Hosp, Dept Clin & Biol Sci, Internal Med, Regione Gonzole 10, I-10043 Orbassano, Italy.
EM massimo.terzolo@unito.it
RI Puglisi, Soraya/AAB-9961-2019; Perini, Anna Maria Elena/HHT-1221-2022;
   Terzolo, Massimo/D-5051-2015
OI Terzolo, Massimo/0000-0002-4171-2851; Puglisi,
   Soraya/0000-0002-2883-6139; Perini, Anna Maria Elena/0000-0002-6097-4750
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NR 97
TC 11
Z9 11
U1 2
U2 9
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0021-972X
EI 1945-7197
J9 J CLIN ENDOCR METAB
JI J. Clin. Endocrinol. Metab.
PD FEB 20
PY 2024
VL 109
IS 3
BP E901
EP E919
DI 10.1210/clinem/dgad453
PG 19
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA LF8O1
UT WOS:001185460100001
PM 37536275
DA 2025-06-11
ER

PT J
AU Mapanga, W
   Norris, SA
   Craig, A
   Pumpalova, Y
   Ayeni, OA
   Chen, WC
   Jacobson, JS
   Neugut, AI
   Muchengeti, M
   Pentz, A
   Doherty, S
   Minkowitz, S
   Haffejee, M
   Rebbeck, T
   Joffe, M
AF Mapanga, Witness
   Norris, Shane A.
   Craig, Ashleigh
   Pumpalova, Yoanna
   Ayeni, Oluwatosin A.
   Chen, Wenlong Carl
   Jacobson, Judith S.
   Neugut, Alfred I.
   Muchengeti, Mazvita
   Pentz, Audrey
   Doherty, Sean
   Minkowitz, Shauli
   Haffejee, Mohammed
   Rebbeck, Tim
   Joffe, Maureen
TI Prevalence of multimorbidity in men of African descent with and without
   prostate cancer in Soweto, South Africa
SO PLOS ONE
LA English
DT Article
ID METABOLIC SYNDROME; RISK-FACTORS; COMORBIDITIES; ASSOCIATIONS;
   GUIDELINE; MORTALITY; STRESS; COHORT; BREAST
AB Objective
   With increases in chronic disease, men with prostate cancer are likely to have at least one other chronic health condition. The burden and complexity of each additional chronic disease may complicate prostate cancer treatment and reduce survival. In this paper, we describe the frequency of multimorbid chronic diseases, HIV and depression among men in Soweto, South Africa (SA) with and without prostate cancer and determine whether the presence of multimorbid diseases is associated with metastatic and high-risk, non-metastatic prostate cancer.
   Methods
   A population-based case-control study on prostate cancer was conducted among black men in Soweto. All participants completed a baseline survey on sociodemographics, lifestyle, and comorbid medical conditions. All participants completed a depression screening survey and HIV testing at enrolment. Blood pressure measurements and blood testing for fasting glucose, total cholesterol, and high-density lipoprotein were performed on a subset of randomly selected cases and controls. For men with prostate cancer, clinical T staging was assessed with the digital rectal examination, the diagnosis was confirmed with a biopsy and PSA levels were assessed at presentation. The metastatic staging was assessed by bone scans, and this was confirmed with PSMA PET scans, CT scans and X-rays, standard for our resource-constrained setting. Normal PSA scores were used as an inclusion criterion for controls.
   Results
   Of the 2136 men (1095 with prostate cancer and 1041 controls) included in the analysis, 43.0% reported at least one chronic metabolic disease; 24.1% reported two metabolic diseases; 5.3% reported three metabolic diseases; and 0.3% reported four metabolic diseases. Men with prostate cancer were more likely to report a multimorbid chronic metabolic disease compared to controls (p<0.001) and more likely to test positive for HIV (p = 0.05). The majority of men (66.2%) reported at least one metabolic disease, tested negative for HIV and had a negative depression screen. The clinical characteristics of men with prostate cancer, were as follows: 396 (36.2%) had a Gleason score of 8 and above; 552 (51.3%) had a PSA score of >20ng/ml; 233 (21.7%) had confirmed metastatic prostate cancer at diagnosis. Older age was associated with metastatic prostate cancer (OR = 1.043 95% CI:1.02-1.07) and NCCN defined high-risk non-metastatic prostate cancer (OR = 1.03 95% CI:1.01-1.05), whilst being hypertensive was protective (OR = 0.63 95% CI:0.47-0.84 and OR = 0.55 95% CI:0.37-0.83) respectively for metastatic and high-risk, non-metastatic prostate cancer.
   Conclusion
   The high prevalence of multimorbid metabolic diseases and HIV among men with prostate cancer represents a public health concern in South Africa. There is a need to effectively address multiple chronic diseases among men with prostate cancer by incorporating coordinated care models.
C1 [Mapanga, Witness; Norris, Shane A.; Ayeni, Oluwatosin A.; Chen, Wenlong Carl; Pentz, Audrey; Joffe, Maureen] Wits Hlth Consortium Pty Ltd, Noncommunicable Dis Res Div, Johannesburg, South Africa.
   [Mapanga, Witness; Norris, Shane A.; Joffe, Maureen] Univ Witwatersrand, Dept Paediat, Fac Hlth Sci, SAMRC Wits Dev Pathways Hlth Res Unit, Johannesburg, South Africa.
   [Mapanga, Witness; Norris, Shane A.; Joffe, Maureen] SAMRC Common Epithelial Canc Res Ctr, Cape Town, South Africa.
   [Mapanga, Witness; Craig, Ashleigh; Ayeni, Oluwatosin A.] Univ Witwatersrand, Sch Clin Med, Div Med Oncol, Dept Med, Johannesburg, South Africa.
   [Norris, Shane A.] Univ Southampton, Global Hlth Res Inst, Sch Human Dev & Hlth, Southampton, Hants, England.
   [Pumpalova, Yoanna; Neugut, Alfred I.] Columbia Univ, Dept Med, Vagelos Coll Phys & Surg, New York, NY USA.
   [Chen, Wenlong Carl; Muchengeti, Mazvita] Natl Hlth Lab Serv, Natl Canc Registry, Johannesburg, South Africa.
   [Chen, Wenlong Carl] Univ Witwatersrand, Sydney Brenner Inst Mol Biosci, Fac Hlth Sci, Johannesburg, South Africa.
   [Jacobson, Judith S.; Neugut, Alfred I.] Columbia Univ, Vagelos Coll Phys & Surg, Herbert Irving Comprehens Canc Ctr, New York, NY USA.
   [Jacobson, Judith S.; Neugut, Alfred I.] Columbia Univ, Mailman Sch Publ Hlth, Dept Epidemiol, New York, NY USA.
   [Doherty, Sean; Minkowitz, Shauli; Haffejee, Mohammed] Univ Witwatersrand, Div Urol, Dept Surg, Fac Hlth Sci, Johannesburg, South Africa.
   [Rebbeck, Tim] Dana Farber Canc Inst, Boston, MA USA.
   [Rebbeck, Tim] Harvard TH Chan Sch Publ Hlth, Boston, MA USA.
C3 University of Witwatersrand; University of Witwatersrand; University of
   Southampton; Columbia University; National Health Laboratory Service;
   University of Witwatersrand; Columbia University; Columbia University;
   University of Witwatersrand; Harvard University; Harvard University
   Medical Affiliates; Dana-Farber Cancer Institute; Harvard University;
   Harvard T.H. Chan School of Public Health
RP Mapanga, W (corresponding author), Wits Hlth Consortium Pty Ltd, Noncommunicable Dis Res Div, Johannesburg, South Africa.; Mapanga, W (corresponding author), Univ Witwatersrand, Dept Paediat, Fac Hlth Sci, SAMRC Wits Dev Pathways Hlth Res Unit, Johannesburg, South Africa.; Mapanga, W (corresponding author), SAMRC Common Epithelial Canc Res Ctr, Cape Town, South Africa.; Mapanga, W (corresponding author), Univ Witwatersrand, Sch Clin Med, Div Med Oncol, Dept Med, Johannesburg, South Africa.
EM wmapanga@witshealth.co.za
RI Norris, Shane/C-4664-2014; Craig, Ashleigh/AAV-7868-2021; Chen,
   Wenlong/ABA-6218-2020; /AHA-6196-2022; Mapanga, Witness/J-1617-2019
OI Joffe, Maureen/0000-0001-8616-9672; Doherty, Sean/0000-0001-5451-892X;
   Ayeni, Oluwatosin/0000-0002-1132-2860; Craig,
   Ashleigh/0000-0002-7641-5953; Chen, Wenlong/0000-0002-3248-4906;
   /0000-0002-1955-923X; Mapanga, Witness/0000-0001-8719-3084
FU NCI [U01CA184374]; DSI-NRF Centre of Excellence in Human Development at
   the University of the Witwatersrand, Johannesburg, South Africa
FX This study was funded by an NCI grant U01CA184374 to TR entitled
   Genetics of Prostate Cancer in Africa. AuthorsWM and SAN are supported
   by the DSI-NRF Centre of Excellence in Human Development at the
   University of the Witwatersrand, Johannesburg, South Africa. The funders
   had no role in study design, data collection and analysis, decision to
   publish, or preparation of the manuscript.
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NR 44
TC 3
Z9 3
U1 0
U2 1
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD OCT 18
PY 2022
VL 17
IS 10
AR e0276050
DI 10.1371/journal.pone.0276050
PG 14
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 7H8CW
UT WOS:000903426100021
PM 36256648
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Cassar, A
   Chareonthaitawee, P
   Rihal, CS
   Prasad, A
   Lennon, RJ
   Lerman, LO
   Lerman, A
AF Cassar, Andrew
   Chareonthaitawee, Panithaya
   Rihal, Charanjit S.
   Prasad, Abhiram
   Lennon, Ryan J.
   Lerman, Lilach O.
   Lerman, Amir
TI Lack of Correlation Between Noninvasive Stress Tests and Invasive
   Coronary Vasomotor Dysfunction in Patients With Nonobstructive Coronary
   Artery Disease
SO CIRCULATION-CARDIOVASCULAR INTERVENTIONS
LA English
DT Article
DE vasomotor dysfunction; coronary artery disease; microcirculation;
   endothelium; stress test
ID CARDIOVASCULAR MAGNETIC-RESONANCE; EMISSION COMPUTED-TOMOGRAPHY;
   MYOCARDIAL-PERFUSION DEFECTS; CARDIAC SYNDROME-X; CHEST-PAIN;
   ENDOTHELIAL DYSFUNCTION; FLOW RESERVE; MICROVASCULAR DYSFUNCTION;
   DOPPLER-ECHOCARDIOGRAPHY; CLINICAL-APPLICATIONS
AB Background - Despite a nonobstructive coronary angiogram, many patients may still have an abnormal coronary vasomotor response to provocation and to myocardial demand during stress. The ability of noninvasive stress tests to predict coronary vasomotor dysfunction in patients with nonobstructive coronary artery disease is unknown.
   Methods and Results - All patients with nonobstructive coronary artery disease who had invasive coronary vasomotor assessment and a noninvasive stress test (exercise ECG, stress echocardiography, or stress nuclear imaging) within 6 months of the cardiac catheterization with provocation at our institution were identified (n = 376). Coronary vasomotor dysfunction was defined as a percentage increase in coronary blood flow of <= 50% to intracoronary acetylcholine (endothelium-dependent dysfunction) and/or a coronary flow reserve ratio of <= 2.5 to intracoronary adenosine (endothelium-independent dysfunction). We determined the sensitivity and specificity of various noninvasive stress tests to predict coronary vasomotor dysfunction in these patients. On invasive testing, 233 patients (63%) had coronary vasomotor dysfunction, of which 187 patients (51%) had endothelium-dependent dysfunction, 109 patients (29%) had endothelium-independent dysfunction, and 63 patients (17%) had both. On noninvasive stress testing, 157 (42%) had a positive imaging study and 56 (15%) a positive ECG stress test. The noninvasive stress tests had limited diagnostic accuracy for predicting coronary vasomotor dysfunction (41% sensitivity [95% CI, 34 to 47] and 57% specificity [95% CI, 49 to 66]), endothelium-dependent dysfunction (41% sensitivity [95% CI, 34 to 49] and 58% specificity [95% CI, 50 to 65]), or endothelium-independent dysfunction (46% sensitivity [95% CI, 37 to 56] and 61% specificity [95% CI, 54 to 67]). The exercise ECG test was more specific but less sensitive than the imaging tests.
   Conclusion - This study suggests that a negative noninvasive stress test does not rule out coronary vasomotor dysfunction in symptomatic patients with nonobstructive coronary artery disease. This underscores the need for invasive assessment or novel more sensitive noninvasive imaging for these patients. (Circ Cardiovasc Intervent. 2009;2:237-244.)
C1 [Chareonthaitawee, Panithaya; Rihal, Charanjit S.; Prasad, Abhiram; Lerman, Lilach O.; Lerman, Amir] Mayo Coll Med, Div Cardiovasc Dis, Rochester, MN 55905 USA.
   [Cassar, Andrew] Mayo Coll Med, Dept Internal Med, Rochester, MN 55905 USA.
   [Lennon, Ryan J.] Mayo Coll Med, Div Biomed Stat & Informat, Rochester, MN 55905 USA.
   [Lerman, Lilach O.] Mayo Coll Med, Div Nephrol & Hypertens, Rochester, MN 55905 USA.
C3 Mayo Clinic; Mayo Clinic; Mayo Clinic; Mayo Clinic
RP Lerman, A (corresponding author), Mayo Coll Med, Div Cardiovasc Dis, 200 1st St SW, Rochester, MN 55905 USA.
EM lerman.amir@mayo.edu
RI Lerman, Lilach/M-4962-2017
OI Prasad, Abhiram/0000-0001-9252-5602
FU National Institutes of Health [R01 HL63911, R01 HL77131, R01 DK73608,
   P01 HL85307]; Mayo Foundation
FX The study was supported by National Institutes of Health grants R01
   HL63911, R01 HL77131, R01 DK73608, and P01 HL85307 and the Mayo
   Foundation. Dr Lerman is an Established Investigator of the American
   Heart Association.
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NR 50
TC 75
Z9 77
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1941-7640
EI 1941-7632
J9 CIRC-CARDIOVASC INTE
JI Circ.-Cardiovasc. Interv.
PD JUN
PY 2009
VL 2
IS 3
BP 237
EP 244
DI 10.1161/CIRCINTERVENTIONS.108.841056
PG 8
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 575LF
UT WOS:000276067800012
PM 20031721
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Fabre, O
   Bailly, S
   Mithieux, G
   Legrand, R
   Costentin, C
   Astrup, A
   Pepin, JL
AF Fabre, Odile
   Bailly, Sebastien
   Mithieux, Gilles
   Legrand, Remy
   Costentin, Charlotte
   Astrup, Arne
   Pepin, Jean-Louis
TI Long-term trajectories of weight loss and health outcomes: protocol of
   the SCOOP-RNPC nationwide observational study
SO BMJ OPEN
LA English
DT Article
DE Obesity; NUTRITION & DIETETICS; Observational Study
ID BODY-MASS INDEX; OBESITY; QUESTIONNAIRE; VALIDATION; DEPRESSION;
   STATEMENT; PRESSURE; LIFE
AB Introduction Behavioural weight loss programmes are generally accepted as being beneficial in reducing cardiometabolic risk and improving patient-reported outcomes. However, prospective data from large real-world cohorts are scarce concerning the mid-term and long-term impact of such interventions. The objective of this large prospective cohort study (n>10 000 participants) is to demonstrate the effectiveness of the standardised Nutritional and Psycho-Behavioural Rehabilitation programme (RNPC Programme) in reducing the percentage of subjects requiring insulin and/or other diabetes drug therapy, antihypertensive drugs, lipid-lowering therapies and continuous positive airway pressure therapy for obstructive sleep apnoea after the end of the intervention. The rate of remission of hypertension, type 2 diabetes and sleep apnoea will also be prospectively assessed. Methods This is a prospective multicentre observational study carried out in 92 RNPC centres in France. Participants will follow the standardised RNPC Programme. The prospective dataset will include clinical, anthropometric and biochemical data, comorbidities, medications, body composition, patient-reported outcome questionnaire responses, sleep study data with objective measurements of sleep apnoea severity and surrogate markers of cardiovascular risk (ie, blood pressure and arterial stiffness). About 10 000 overweight or obese participants will be included over 2 years with a follow-up duration of up to 5 years. Ethics and dissemination Ethical approval for this study has been granted by the Ethics Committee (Comit & eacute; de protection des personnes Sud-Est I) of Saint-Etienne University Hospital, France (SI number: 23.00174.000237). Results will be submitted for publication in peer-review journals, presented at conferences and inform the design of a future randomised controlled trial in the specific population identified as good responders to the RNPC Programme.
C1 [Fabre, Odile; Legrand, Remy] SARL Grp Eth & Sante, Marseille, Provence Alpes, France.
   [Bailly, Sebastien; Pepin, Jean-Louis] Univ Grenoble Alpes, Grenoble, France.
   [Bailly, Sebastien; Pepin, Jean-Louis] Grenoble Alpes Univ Hosp, Grenoble, France.
   [Mithieux, Gilles] Univ Claude Bernard Lyon 1, Lyon, France.
   [Costentin, Charlotte] Univ Grenoble Alpes, INSERM U1209, CNRS UMR 5309, Grenoble, France.
   [Costentin, Charlotte] Grenoble Alpes Univ Hosp, Univ Clin Hepatogastroenterol, Grenoble, France.
   [Astrup, Arne] Novo Nordisk Fdn, Dept Obes & Nutr Sci, Hellerup, Denmark.
C3 Communaute Universite Grenoble Alpes; Universite Grenoble Alpes (UGA);
   Communaute Universite Grenoble Alpes; Universite Grenoble Alpes (UGA);
   CHU Grenoble Alpes; Universite Claude Bernard Lyon 1; Institut National
   de la Sante et de la Recherche Medicale (Inserm); Centre National de la
   Recherche Scientifique (CNRS); CNRS - National Institute for Biology
   (INSB); Communaute Universite Grenoble Alpes; Universite Grenoble Alpes
   (UGA); CHU Grenoble Alpes; Communaute Universite Grenoble Alpes;
   Universite Grenoble Alpes (UGA); Novo Nordisk Foundation
RP Fabre, O (corresponding author), SARL Grp Eth & Sante, Marseille, Provence Alpes, France.
EM odile.fabre@groupethiquetsante.com; sbailly@chu-grenoble.fr;
   gilles.mithieux@inserm.fr; remy.legrand@groupethiquetsante.com;
   costentin@chu-grenoble.fr; ARA@novo.dk; JPepin@chu-grenoble.fr
RI Astrup, Arne/HZL-1679-2023; BAILLY, Sébastien/H-4648-2013
FU Groupe Ethique et Sante (Aubagne, near Marseille, France)
FX This study is funded by the Groupe Ethique et Sante (Aubagne, near
   Marseille, France) and the non- profit organization (law of 1901) 'Union
   Francaise pour la Sante Cardio- Vasculaire et Articulaire (UFSCVA)'.
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NR 42
TC 1
Z9 1
U1 0
U2 0
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2044-6055
J9 BMJ OPEN
JI BMJ Open
PD JUL 10
PY 2024
VL 14
IS 7
BP 1
EP 12
DI 10.1136/bmjopen-2023-082575
PG 12
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA E9T0V
UT WOS:001306342000001
PM 38991672
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Martínez-Velilla, N
   Valenzuela, PL
   de Asteasu, MLS
   Zambom-Ferraresi, F
   Ramírez-Vélez, R
   García-Hermoso, A
   Librero-López, J
   Gorricho, J
   Pérez, FE
   Lucia, A
   Izquierdo, M
AF Martinez-Velilla, Nicolas
   Valenzuela, Pedro L.
   de Asteasu, Mikel L. Saez
   Zambom-Ferraresi, Fabricio
   Ramirez-Velez, Robinson
   Garcia-Hermoso, Antonio
   Librero-Lopez, Julian
   Gorricho, Javier
   Perez, Federico Esparza
   Lucia, Alejandro
   Izquierdo, Mikel
TI Effects of a Tailored Exercise Intervention in Acutely Hospitalized
   Oldest Old Diabetic Adults: An Ancillary Analysis
SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Article
DE multicomponent physical exercise intervention; functional decline;
   cognitive impairment; cardiometabolic risk factors; Vivifrail
ID POSITION STATEMENT; MOBILITY; ASSOCIATION; DISABILITY; SARCOPENIA;
   IMPACT; CARE
AB Objective To analyze the effects of a tailored exercise intervention in acutely hospitalized elderly diabetic patients.
   Research Design and Methods This is an ancillary analysis of a randomized controlled trial (RCT). A total of 103 acutely hospitalized elderly adults (mean age similar to 87 years) with type II diabetes were randomized to an intervention (exercise, n = 54) or control group (usual care, n = 49). The primary endpoint was change in functional status from baseline to hospital discharge as assessed with the Barthel Index and the Short Physical Performance Battery (SPPB). Secondary endpoints comprised cognitive function and mood status, quality of life (QoL), incidence of delirium, and handgrip strength. Exercise-related side effects, length of hospital stay, and incidence of falls during hospitalization were also assessed, as well as transfer to nursing homes, hospital readmission, and mortality during a 3-month follow-up.
   Results The median length of stay was 8 days (interquartile range, 4) for both groups. The intervention was safe and provided significant benefits over usual care on SPPB (2.7 [95% confidence interval (CI) 1.8, 3.5]) and Barthel Index (8.5 [95% CI: 3.9, 13.1]), as well as on other secondary endpoints such as cognitive status, depression, QoL, and handgrip strength (all P < 0.05). No significant between-group differences were found for the remainder of secondary endpoints.
   Conclusions An in-hospital individualized multicomponent exercise intervention was safe and effective for the prevention of functional and cognitive decline in acutely hospitalized elderly diabetic patients, although it had no influence on other endpoints assessed during hospitalization or at the 3-month follow-up after discharge.
C1 [Martinez-Velilla, Nicolas; de Asteasu, Mikel L. Saez; Zambom-Ferraresi, Fabricio; Ramirez-Velez, Robinson; Garcia-Hermoso, Antonio; Librero-Lopez, Julian; Izquierdo, Mikel] Univ Publ Navarra, Inst Hlth Res Navarre IdiSNA, Navarrabiomed, Complejo Hosp Navarra, Pamplona 31008, Spain.
   [Martinez-Velilla, Nicolas; de Asteasu, Mikel L. Saez; Zambom-Ferraresi, Fabricio; Ramirez-Velez, Robinson; Garcia-Hermoso, Antonio; Lucia, Alejandro; Izquierdo, Mikel] Inst Salud Carlos III, Networking Biomed Res Ctr CIBER Frailty & Hlth Ag, Madrid 28029, Spain.
   [Valenzuela, Pedro L.] Univ Alcala, Dept Syst Biol, Madrid 28805, Spain.
   [Garcia-Hermoso, Antonio] Univ Santiago Chile, Fac Ciencias Med, USACH, Lab Ciencias Actividad Fis Deporte & Salud, Santiago, Chile.
   [Gorricho, Javier; Perez, Federico Esparza] Govt Navarra, Dept Hlth, Pamplona 31002, Spain.
   [Lucia, Alejandro] Univ Europea Madrid, Fac Sport Sci, Madrid 28670, Spain.
   [Lucia, Alejandro] Res Inst Hosp 12 Octubre, Madrid 28670, Spain.
C3 Servicio Navarro de Salud - Osasunbidea; Navarrabiomed; Universidad
   Publica de Navarra; Instituto de Salud Carlos III; Universidad de
   Alcala; Universidad de Santiago de Chile; European University of Madrid;
   Hospital Universitario 12 de Octubre
RP Izquierdo, M (corresponding author), Inst Salud Carlos III, Networking Biomed Res Ctr CIBER Frailty & Hlth Ag, Madrid 28029, Spain.; Izquierdo, M (corresponding author), Univ Publ Navarra, Dept Hlth Sci, Av Baranain S-N, Navarra 31008, Spain.
EM mikel.izquierdo@gmail.com
RI Asteasu, Mikel/A-8973-2017; Valenzuela, Pedro/O-7601-2019;
   García-Hermoso, Antonio/ADU-2591-2022; Gorricho, Javier/H-2065-2015;
   Ramirez-Velez, Robinson/D-5311-2016; Izquierdo, Mikel/A-4894-2010;
   Garcia-Hermoso, Antonio/P-1857-2017; Librero, Julian/F-4947-2017;
   Zambom-Ferraresi, Fabricio/M-1906-2018; Martinez-Velilla,
   Nicolas/A-6942-2017
OI Gorricho, Javier/0000-0003-3609-9922; Ramirez-Velez,
   Robinson/0000-0003-3075-6960; Izquierdo, Mikel/0000-0002-1506-4272;
   Garcia-Hermoso, Antonio/0000-0002-1397-7182; Librero,
   Julian/0000-0002-4859-9054; Zambom-Ferraresi,
   Fabricio/0000-0002-8377-9827; Saez de Asteasu, Mikel
   Lopez/0000-0002-4111-5045; Martinez-Velilla, Nicolas/0000-0001-9576-9960
FU Gobierno de Navarra [2186/2014]; Ministerio de Economia, Industria y
   Competitividad (ISCIII, FEDER) [PI17/01814]; Fondos FEDER [PI15/00558];
   ISCIII
FX N.M.V. was funded by a Gobierno de Navarra project Resolucion grant
   2186/2014 and was acknowledged with the "Beca Ortiz de Landazuri" for
   the best research clinical project in 2014, as well as Fundacion Caja
   Navarra and Fundacion La Caixa. M.I. was funded by research grant
   PI17/01814 of the Ministerio de Economia, Industria y Competitividad
   (ISCIII, FEDER). A.L. was funded by ISCIII and Fondos FEDER
   (PI15/00558).
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NR 36
TC 18
Z9 19
U1 1
U2 39
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0021-972X
EI 1945-7197
J9 J CLIN ENDOCR METAB
JI J. Clin. Endocrinol. Metab.
PD JAN 23
PY 2021
VL 106
IS 2
BP E899
EP E906
DI 10.1210/clinem/dgaa809
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA ZE8GF
UT WOS:000759115900070
PM 33150389
DA 2025-06-11
ER

PT J
AU Ojo, SO
   Bailey, DP
   Chater, AM
   Hewson, DJ
AF Ojo, Samson O.
   Bailey, Daniel P.
   Chater, Angel M.
   Hewson, David J.
TI Workplace Intervention for Reducing Sitting Time in Sedentary Workers:
   Protocol for a Pilot Study Using the Behavior Change Wheel
SO FRONTIERS IN PUBLIC HEALTH
LA English
DT Article
DE sedentary behavior; Behavior Change Wheel; intervention; desk-based
   employees; office workers; pilot study; protocol
ID ECOLOGICAL MOMENTARY ASSESSMENT; PHYSICAL-ACTIVITY; NEGATIVE AFFECT;
   HEALTH; OFFICE; ASSOCIATIONS; VALIDATION; VALIDITY; ADULTS; TRIAL
AB The workplace is a major contributor to excessive sitting in office workers. There are a wide array of adverse effects of high volumes of sitting time, including an increased risk of type 2 diabetes and depression. Active workstations can be used in effective interventions to decrease workplace sitting. However, there are a lack of interventions that have been developed using a systematic process that is informed by participant needs and a framework for identifying the most appropriate content for the intervention. Applying these methods could increase adherence and potential effectiveness of the intervention. Therefore, the purpose of this pilot study is to examine the feasibility, acceptability, and efficacy of a tailored workplace intervention to reduce and break up sitting in office workers that has been developed using the Behavior Change Wheel and the APEASE (Acceptability, Practicability, Effectiveness/cost-effectiveness, Affordability, Safety/side-effects, Equity) criteria. This article reports the protocol for this study that is currently ongoing. Participants will be cluster-randomized (by offices) to control and intervention groups. The evaluation of the intervention includes determining feasibility by assessing participant recruitment, retention and data completion rates. Adherence to the intervention will be assessed based on daily sitting and standing time relative to guidelines provided to participants as part of the intervention. Outcome measures also include productivity measured using Ecological Momentary Assessment, absenteeism, presenteeism, cardiometabolic risk markers, and wellbeing. The findings of this study will inform the effective design and implementation of interventions for reducing and breaking up sitting in office workers.
C1 [Ojo, Samson O.; Hewson, David J.] Univ Bedfordshire, Inst Hlth Res, Luton, Beds, England.
   [Ojo, Samson O.] Northampton Gen Hosp NHS Trust, Qual Improvement, Northampton, England.
   [Bailey, Daniel P.; Chater, Angel M.] Univ Bedfordshire, Ctr Hlth Wellbeing & Behav Change, Inst Sport & Phys Act Res, Bedford, England.
   [Bailey, Daniel P.] Brunel Univ London, Dept Life Sci, Div Spat Hlth & Exercise Sci, Uxbridge, Middx, England.
   [Bailey, Daniel P.] Brunel Univ London, Ctr Phys Act Hlth & Dis, Uxbridge, Middx, England.
   [Chater, Angel M.] UCL, Ctr Behav Change, London, England.
C3 University of Bedfordshire; University of Bedfordshire; Brunel
   University; Brunel University; University of London; University College
   London
RP Bailey, DP; Chater, AM (corresponding author), Univ Bedfordshire, Ctr Hlth Wellbeing & Behav Change, Inst Sport & Phys Act Res, Bedford, England.; Bailey, DP (corresponding author), Brunel Univ London, Dept Life Sci, Div Spat Hlth & Exercise Sci, Uxbridge, Middx, England.; Bailey, DP (corresponding author), Brunel Univ London, Ctr Phys Act Hlth & Dis, Uxbridge, Middx, England.; Chater, AM (corresponding author), UCL, Ctr Behav Change, London, England.
EM daniel.bailey@brunel.ac.uk; angel.chater@beds.ac.uk
RI Bailey, Daniel/HDL-7697-2022
OI Bailey, Daniel/0000-0003-3772-630X; Chater, Angel
   Marie/0000-0002-9043-2565
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NR 66
TC 2
Z9 2
U1 5
U2 33
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 2296-2565
J9 FRONT PUBLIC HEALTH
JI Front. Public Health
PD APR 12
PY 2022
VL 10
AR 832374
DI 10.3389/fpubh.2022.832374
PG 13
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA 0U6DG
UT WOS:000787739100001
PM 35493386
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Hsueh, LRT
   Iturralde, E
   Slama, NE
   Spalding, SR
   Sterling, SA
AF Hsueh, Loretta
   Iturralde, Esti
   Slama, Natalie E.
   Spalding, Scott R.
   Sterling, Stacy A.
TI Cardiometabolic Monitoring and Sociodemographic and Clinical
   Characteristics of Youths Prescribed Antipsychotic Medications
SO PSYCHIATRIC SERVICES
LA English
DT Article
ID SEVERE MENTAL-ILLNESS; 2ND-GENERATION ANTIPSYCHOTICS; SUBSTANCE USE;
   CHILDREN; METAANALYSIS; ADULTS; RISK; ADOLESCENTS; DEPRESSION; DISEASE
AB Objective: This study examined time trends and patient characteristics related to guideline-recommended cardiometabolic risk factor monitoring among youths treated with antipsychotic medications.Methods: This observational study assessed participant sociodemographic and clinical characteristics and year of antipsychotic medication initiation, with receipt of glycemic and lipid testing within 2 years of initiation as the primary outcome. Electronic health records and pharmacy data from Kaiser Permanente Northern California for 4,568 youths (ages 10-21 years) who began antipsychotic medication treatment during 2013-2017 were included.Results: Mean +/- SD age of the sample was 17.0 +/- 3.0 years, 52% were male, and 50% were Asian American, Native Hawaiian, or Pacific Islander; Black; Latino; or another or unknown race-ethnicity. Overall, 54% of the sample completed glycemic and lipid monitoring within 2 years of medication initiation (41% within 1 year). With each study year, monitoring rates increased by 5% in this cohort, after the analyses were adjusted for participant factors (p=0.001). In the fully adjusted analysis, youths with a psychotic disorder were 23% more likely to receive cardiometabolic monitoring than those without a psychotic disorder or bipolar disorder (p<0.001). Monitoring was also more common among younger versus older adolescents and among those with risperidone (vs. quetiapine) medication, obesity, or more frequent use of outpatient health care. Youths with (vs. without) substance use disorder were 19% less likely to complete monitoring (p<0.001).Conclusions: Cardiometabolic monitoring increased modestly over time, but close to half of the studied youths did not receive glycemic or lipid testing. Additional clinical strategies may be needed to increase monitoring overall and among harder-to-reach youth subgroups
C1 [Hsueh, Loretta; Iturralde, Esti; Slama, Natalie E.; Spalding, Scott R.; Sterling, Stacy A.] Kaiser Permanente Northern Calif, Kaiser Permanente Northern Calif Div Res, Oakland, CA 94611 USA.
   [Spalding, Scott R.] PermanenteMed Grp Flanagan, Oakland, ON, Canada.
C3 Kaiser Permanente
RP Iturralde, E (corresponding author), Kaiser Permanente Northern Calif, Kaiser Permanente Northern Calif Div Res, Oakland, CA 94611 USA.
EM estibaliz.m.iturralde@kp.org
OI Slama, Natalie/0000-0002-4930-1061
FU Kaiser Permanente Northern California Division of Research
FX This study was supported by a grant from the Kaiser Permanente Northern
   California Division of Research, Behavioral Health, Aging, and
   Infectious Diseases Section. Dr. Hsueh received funding from the
   Permanente Medical Group's Delivery Science Fellowship Program and the
   National Institute of Diabetes and Digestive and Kidney Diseases
   (T32-DK-11668401) . Dr. Iturralde was supported by the NIMH (K23-MH-
   126078) .
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NR 41
TC 6
Z9 6
U1 1
U2 2
PU AMER PSYCHIATRIC PUBLISHING, INC
PI WASHINGTON
PA 800 MAINE AVE SW, SUITE 900, WASHINGTON, DC 20024 USA
SN 1075-2730
EI 1557-9700
J9 PSYCHIAT SERV
JI Psychiatr. Serv.
PD AUG
PY 2023
VL 74
IS 8
BP 801
EP 808
DI 10.1176/appi.ps.20220151
PG 8
WC Health Policy & Services; Public, Environmental & Occupational Health;
   Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services; Public, Environmental & Occupational
   Health; Psychiatry
GA T7OF0
UT WOS:001079832100003
PM 37016828
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Luszczki, E
   Wyszynska, J
   Dymek, A
   Drozdz, D
   Gonzalez-Ramos, L
   Hartgring, I
   García-Carbonell, N
   Mazur, A
   Erdine, S
   Parnarauskiene, J
   Alvarez-Pitti, J
   eprObes Consortium
AF Luszczki, Edyta
   Wyszynska, Justyna
   Dymek, Agnieszka
   Drozdz, Dorota
   Gonzalez-Ramos, Laura
   Hartgring, Isa
   Garcia-Carbonell, Nuria
   Mazur, Artur
   Erdine, Serap
   Parnarauskiene, Juste
   Alvarez-Pitti, Julio
   eprObes Consortium
TI The Effect of Maternal Diet and Lifestyle on the Risk of Childhood
   Obesity
SO METABOLITES
LA English
DT Review
DE childhood obesity; fetal programming; epigenetics; maternal lifestyle;
   maternal diet; gut microbiota; gestational diabetes; obesogenes
ID OFFSPRING BODY-COMPOSITION; GUT MICROBIOME; NONCODING RNAS;
   DEVELOPMENTAL ORIGINS; CARDIOMETABOLIC RISK; DNA METHYLATION; GLYCEMIC
   INDEX; PREGNANCY; HEALTH; ASSOCIATIONS
AB Background/Objectives: Childhood obesity is a global health problem that affects at least 41 million children under the age of five. Increased BMI in children is associated with serious long-term health consequences, such as type 2 diabetes, cardiovascular disease, and psychological problems, including depression and low self-esteem. Although the etiology of obesity is complex, research suggests that the diet and lifestyle of pregnant women play a key role in shaping metabolic and epigenetic changes that can increase the risk of obesity in their children. Excessive gestational weight gain, unhealthy dietary patterns (including the Western diet), and pregnancy complications (such as gestational diabetes) are some of the modifiable factors that contribute to childhood obesity. The purpose of this narrative review is to summarize the most important and recent information on the impact of the diet and lifestyle of pregnant women on the risk of childhood obesity. Methods: This article is a narrative review that aims to summarize the available literature on the impact of pregnant women's diet and lifestyle on the risk of obesity in their offspring, with a focus on metabolic and epigenetic mechanisms. Results/Conclusions: Current evidence suggests that a pregnant woman's lifestyle and diet can significantly contribute to lowering the risk of obesity in their offspring. However, further high-quality research is needed to understand better the metabolic and epigenetic relationships concerning maternal factors that predispose offspring to obesity.
C1 [Luszczki, Edyta; Wyszynska, Justyna; Dymek, Agnieszka] Rzeszow Univ, Inst Hlth Sci, Med Coll, PL-35959 Rzeszow, Poland.
   [Drozdz, Dorota] Jagiellonian Univ, Pediat Inst, Med Coll, Dept Pediat Nephrol & Hypertens, PL-31007 Krakow, Poland.
   [Gonzalez-Ramos, Laura; Hartgring, Isa; Garcia-Carbonell, Nuria; Alvarez-Pitti, Julio] Univ Valencia, Consorcio Hosp Gen, Fdn Invest, Innovat Paediat & Technol iPEDITEC Res Grp, Valencia 46010, Spain.
   [Garcia-Carbonell, Nuria; Alvarez-Pitti, Julio] Univ Valencia, Consorcio Hosp Gen, Pediat Dept, Valencia 46014, Spain.
   [Mazur, Artur] Rzeszow Univ, Inst Med Sci, Med Coll, PL-35959 Rzeszow, Poland.
   [Erdine, Serap] Istanbul Univ Cerrahpasa, Cerrahpasa Fac Med, Dept Cardiol, TR-34320 Istanbul, Turkiye.
   [Parnarauskiene, Juste] Vilnius Univ Hosp St Klin, Pediat Dept, LT-08661 Vilnius, Lithuania.
   [Alvarez-Pitti, Julio] Inst Salud Carlos III, CIBER Fisiopatol Obes & Nutr CIBERObn, Madrid 28029, Spain.
C3 University of Rzeszow; Jagiellonian University; Collegium Medicum
   Jagiellonian University; University of Valencia; University of Valencia;
   University of Rzeszow; Istanbul University - Cerrahpasa; CIBER - Centro
   de Investigacion Biomedica en Red; CIBEROBN; Instituto de Salud Carlos
   III
RP Luszczki, E (corresponding author), Rzeszow Univ, Inst Hlth Sci, Med Coll, PL-35959 Rzeszow, Poland.
EM eluszczki@ur.edu.pl; jwyszynska@ur.edu.pl; adymek@ur.edu.pl;
   dorota.drozdz@uj.edu.pl; lauragonzalezramos99@gmail.com;
   isahartgring@gmail.com; nuria.garcia-carbonell@uv.es;
   drmazur@poczta.onet.pl; serap.erdine@gmail.com;
   juste.parnarauskiene@santa.lt; japnago@gmail.com
RI Dymek, Agnieszka/NJR-9036-2025; Łuszczki, Edyta/AAP-1883-2020; mazur,
   andre/ABC-8971-2021; Wyszynska, Justyna/L-5315-2016; Alvarez Pitti,
   Julio/M-2552-2018
OI Wyszynska, Justyna/0000-0002-5786-6214; Drozdz,
   Dorota/0000-0002-1281-1164; Parnarauskiene, Juste/0009-0002-5654-6021;
   Alvarez Pitti, Julio/0000-0003-0452-7822; Mazur,
   Artur/0000-0001-5393-3515; Luszczki, Edyta/0000-0002-4619-7705
FU European Union [GA 101080219]; European Union through the Horizon Europe
   Framework Programme
FX This article is based upon work from the eprObes project (GA 101080219),
   funded by the European Union through the Horizon Europe Framework
   Programme.
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   ,, 2012, EFSA Journal, V10, P2832
NR 155
TC 0
Z9 0
U1 8
U2 8
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2218-1989
J9 METABOLITES
JI Metabolites
PD DEC
PY 2024
VL 14
IS 12
AR 655
DI 10.3390/metabo14120655
PG 20
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA Q4T8S
UT WOS:001384634000001
PM 39728436
OA gold
DA 2025-06-11
ER

PT J
AU Mariolis, A
   Foscolou, A
   Tyrovolas, S
   Piscopo, S
   Valacchi, G
   Tsakountakis, N
   Zeimbekis, A
   Bountziouka, V
   Gotsis, E
   Metallinos, G
   Tyrovola, D
   Tur, JA
   Matalas, AL
   Lionis, C
   Polychronopoulos, E
   Panagiotakos, D
AF Mariolis, Anargiros
   Foscolou, Alexandra
   Tyrovolas, Stefanos
   Piscopo, Suzanne
   Valacchi, Giuseppe
   Tsakountakis, Nikos
   Zeimbekis, Akis
   Bountziouka, Vassiliki
   Gotsis, Efthimios
   Metallinos, George
   Tyrovola, Dimitra
   Tur, Josep-Antoni
   Matalas, Antonia-Leda
   Lionis, Christos
   Polychronopoulos, Evangelos
   Panagiotakos, Demosthenes
CA MEDIS Study Grp
TI Successful Aging among Elders Living in the Mani Continental Region vs.
   Insular Areas of the Mediterranean: the MEDIS Study
SO AGING AND DISEASE
LA English
DT Article
DE successful aging; longevity; Mani region; Mediterranean islands;
   cardiometabolic risk; lifestyle
ID HEALTH-STATUS; OLDER-ADULTS; RISK-FACTORS; DIET; ALCOHOL; INDIVIDUALS;
   DEPRESSION; VALIDATION; COMPONENTS; FRAILTY
AB To evaluate the role of geography i.e., continental vs. insular Mediterranean, on successful aging among older inhabitants. During 2005-2014, 2693 elderly (aged 65 to 100 years) individuals from 21 Mediterranean islands in Greece, Italy and Spain as well as Cyprus, Malta, and the rural region of Mani (southeast continental region of Greece keeping old-time traditions), were voluntarily recruited. Successful aging was evaluated using a validated index composed of 10 health-related socio-lifestyle and clinical characteristics. After accounting for age, sex, body mass index (BMI), physical activity, smoking habits, MedDietScore and access to health care services, the older inhabitants of islands were found to have a higher level of the successful aging index when compared to their counterparts in Mani (Beta=0.174, p<0.001); moreover, islanders exhibited slightly more years of "good" health (68.7 vs 68.4 years for Mani residents (p=0.99)). However, compared to the residents of Mani, islanders had 1.64 times higher odds (95% CI, 1.08-2.48) for having hypertension, 2.4-times higher odds (95% CI, 1.34-4.21) for having diabetes and 1.52 times higher odds (95% CI, 0.97-2.38) for having hypercholesterolemia. Engaging in physical activities and healthy dietary habits were the major determinants of healthy aging, among islanders as compared to their counterparts of continental Mani region. Elder residents of the continental Mani area enjoyed a better health status, whereas elder islanders had a higher level of successful aging; a finding which could be attributed to differences in lifestyle among elders.
C1 [Mariolis, Anargiros] Gen Hosp Sparta, Hlth Ctr Areopolis, Areopolis, Greece.
   [Foscolou, Alexandra; Tyrovolas, Stefanos; Bountziouka, Vassiliki; Gotsis, Efthimios; Metallinos, George; Tyrovola, Dimitra; Matalas, Antonia-Leda; Polychronopoulos, Evangelos; Panagiotakos, Demosthenes] Harokopio Univ, Dept Nutr & Dietet, Sch Hlth Sci & Educ, Athens, Greece.
   [Tyrovolas, Stefanos] Univ Barcelona, Fundacio Sant Joan Deu, CIBERSAM, Parc Sanitari Sant Joan Deu, Barcelona, Spain.
   [Piscopo, Suzanne] Univ Malta, Nutr Family & Consumer Studies Off, Msida, Malta.
   [Valacchi, Giuseppe] Univ Ferrara, Dept Life Sci & Biotechnol, Ferrara, Italy.
   [Tsakountakis, Nikos; Lionis, Christos] Univ Crete, Clin Social & Family Med, Sch Med, Iraklion, Greece.
   [Zeimbekis, Akis] Gen Hosp Mitilini, Hlth Ctr Kalloni, Mitilini, Greece.
   [Tur, Josep-Antoni] Univ Illes Balears, Res Grp Community Nutr & Oxidat Stress, E-07122 Palma De Mallorca, Spain.
   [Tur, Josep-Antoni] CIBERobn, E-07122 Palma De Mallorca, Spain.
C3 Harokopio University Athens; CIBER - Centro de Investigacion Biomedica
   en Red; CIBERSAM; University of Barcelona; University of Malta;
   University of Ferrara; University of Crete; Universitat de les Illes
   Balears; CIBER - Centro de Investigacion Biomedica en Red; CIBEROBN
RP Panagiotakos, D (corresponding author), 46 Paleon Polemiston St, Glifadha 16674, Attica, Greece.
EM dbpanag@hua.gr
RI Tyrovolas, Stefanos/M-2758-2014; Matalas, Antonia/AAM-3933-2021;
   Foscolou, Alexandra/AAZ-1288-2020; Panagiotakos,
   Demosthenes/K-8294-2019; Lionis, Christos/MBV-1499-2025; Tur,
   Josep/AAE-5748-2020; Bountziouka, Vasiliki/I-6297-2018
OI Bountziouka, Vasiliki/0000-0003-2522-1582; Matalas,
   Antonia/0000-0003-0750-7923; Foscolou, Alexandra/0000-0002-8068-577X;
   GKOTSIS, EFTHYMIOS/0000-0001-5949-7523; PISCOPO,
   SUZANNE/0000-0002-5852-7708
FU Hellenic Heart Foundation; Graduate program of the Department of
   Nutrition and Dietetics, Harokopio University in Athens, Greece;
   Foundation for Education and European Culture (IPEP);  [PI11/01791]; 
   [CIBERobn CB12/03/30038];  [CAIB/EU 35/2001]
FX The study has been funded by the Hellenic Heart Foundation and the
   Graduate program of the Department of Nutrition and Dietetics, Harokopio
   University in Athens, Greece. Stefano Tyrovolas' work was funded through
   a scholarship from the Foundation for Education and European Culture
   (IPEP). Josep A. Tur was funded by grants PI11/01791, CIBERobn
   CB12/03/30038, and CAIB/EU 35/2001.
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NR 36
TC 10
Z9 10
U1 0
U2 11
PU INT SOC AGING & DISEASE
PI FORT WORTH
PA EDITORIAL OFF, 3400 CAMP BOWIE BLVD, FORT WORTH, TX 76106 USA
SN 2152-5250
J9 AGING DIS
JI Aging Dis.
PD JUN
PY 2016
VL 7
IS 3
BP 285
EP 294
DI 10.14336/AD.2015.1002
PG 10
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA DY1FJ
UT WOS:000384840000010
PM 27330843
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Feter, N
   Feter, JS
   Borelli, WV
   Rombaldi, AJ
   Castilhos, RM
AF Feter, Natan
   Feter, Jayne S.
   Borelli, Wyllians V.
   Rombaldi, Airton J.
   Castilhos, Raphael M.
TI Potentially modifiable risk factors for dementia in six low-income and
   middle-income countries: A multinational, population-based survey
SO MATURITAS
LA English
DT Article
DE Dementia; Population attributable fraction; Risk factors
AB Objectives: We aimed to determine the proportion of dementia cases potentially preventable in six low-income and middle -income countries. Study design: We analyzed data from 19,278 adults aged 50 years or more from China, South Africa, Ghana, India, Russia, and Mexico included in the WHO's Study on global AGEing and adult health. Main outcome measures: We calculated the population attributable fraction for ten potentially modifiable risk factors: less education, hearing loss, hypertension, diabetes, depression, heavy drinking, obesity, smoking, physical inactivity, and social isolation. Weighted attributable fraction was calculated considering communality among risk factors. Results: We estimated that 37.6 % of the burden of dementia might be attributable to these risk factors. The highest and lowest overall weighted attributable fractions were 38.3 % and 22.9 % in China and Ghana, respectively. Less education (8.3 %), smoking (6.3 %), and physical inactivity (5.7 %) showed the highest attributable fraction for dementia. The overall attributable fraction was higher in the poorest (38.1 %) than in the richest (30.9 %) income quintile. The burden of obesity, diabetes, and hypertension was 61 % higher in the wealthiest than in the poorest population. A total of 7.2 million cases of dementia in these six low- and middleincome countries are potentially caused by these ten potentially modifiable risk factors. Conclusions: Overall, 38 % of cases of dementia in China, South Africa, Ghana, India, Russia, and Mexico can be attributable to ten potentially modifiable risk factors. Cardiometabolic risk factors account for a more significant burden of dementia in the wealthiest population. Less education had the highest population attributable fraction independent of living area and income.
C1 [Feter, Natan] Univ Fed Rio Grande Do Sul, Postgrad Program Epidemiol, Av Protasio Alves 211, Porto Alegre, RS, Brazil.
   [Feter, Jayne S.] Univ Fed Rio Grande Do Sul, Postgrad Program Hlth Sci, Rua Ramiro Barcelos 2400, BR-90035007 Porto Alegre, RS, Brazil.
   [Borelli, Wyllians V.; Castilhos, Raphael M.] Hosp Clin Porto Alegre, Ctr Neurol Cognit & Comportamento, Serv Neurol, Rua Ramiro Barcelos 2350, BR-9003590 Porto Alegre, RS, Brazil.
   [Rombaldi, Airton J.] Univ Fed Pelotas, Postgrad Program Phys Educ, Rua Luiz Camoes 625, BR-96055630 Pelotas, RS, Brazil.
   [Feter, Natan] Hosp Clin Porto Alegre, Clin Res Ctr, Av Protasio Alves 211, BR-90035903 Porto Alegre, RS, Brazil.
C3 Universidade Federal do Rio Grande do Sul; Universidade Federal do Rio
   Grande do Sul; Hospital de Clinicas de Porto Alegre; Universidade
   Federal de Pelotas; Hospital de Clinicas de Porto Alegre
RP Feter, N (corresponding author), Hosp Clin Porto Alegre, Clin Res Ctr, Av Protasio Alves 211, BR-90035903 Porto Alegre, RS, Brazil.
EM natanfeter@hotmail.com; wborelli@hcpa.edu.br; rcastilhos@hcpa.edu.br
RI Castilhos, Raphael/V-9098-2019; Feter, Natan/AAD-7863-2022; Vendramini
   Borelli, Wyllians/F-5585-2016; Rombaldi, Airton/AAM-6492-2021
OI Castilhos, Raphael/0000-0002-1905-2084; Vendramini Borelli,
   Wyllians/0000-0001-9282-0601; Rombaldi, Airton/0000-0002-6707-814X
FU National Council for Scientific and Technological Development (CNPq)
   [307147/2022-3]; Fundacao de Amparo a Pesquisa do Estado do Rio Grande
   do Sul (FAPERGS) [21/2551-0002071-7]; Alzheimer's Association [AARG-D
   21-846545, AACSFD-22-928689]; Coordenacao de Aperfeicoamento de Pessoal
   de Nivel Superior-Brasil [001]
FX NF and AJR are supported by the National Council for Scientific and
   Technological Development (CNPq) (307147/2022-3) and the Fundacao de
   Amparo a Pesquisa do Estado do Rio Grande do Sul (FAPERGS)
   (21/2551-0002071-7) . RMC has received funding from the Alzheimer's
   Association (AARG-D 21-846545) . WVB has received funding from the
   Alzheimer's Association (AACSFD-22-928689) . JSF is supported in part by
   the Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior-Brasil
   (CAPES) -Finance Code 001.
CR Ahmadi-Abhari S, 2017, BMJ-BRIT MED J, V358, DOI 10.1136/bmj.j2856
   [Anonymous], 2018, Dementia: A Public Health Priority
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   Collaborators GBD 2019 DF, 2022, Lancet Public Health
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NR 23
TC 0
Z9 0
U1 0
U2 1
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0378-5122
EI 1873-4111
J9 MATURITAS
JI Maturitas
PD MAY
PY 2024
VL 183
AR 107968
DI 10.1016/j.maturitas.2024.107968
EA MAR 2024
PG 6
WC Geriatrics & Gerontology; Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology; Obstetrics & Gynecology
GA OB9Q7
UT WOS:001204921800001
PM 38484600
DA 2025-06-11
ER

PT J
AU Paz-Barba, M
   Garcia, AM
   de Winter, TJJ
   de Graaf, N
   van Agen, M
   van der Sar, E
   Lambregtse, F
   Daleman, L
   van der Slik, A
   Zaldumbide, A
   de Koning, EJP
   Carlotti, F
AF Paz-Barba, Miriam
   Munoz Garcia, Amadeo
   de Winter, Twan J. J.
   de Graaf, Natascha
   van Agen, Maarten
   van der Sar, Elisa
   Lambregtse, Ferdy
   Daleman, Lizanne
   van der Slik, Arno
   Zaldumbide, Arnaud
   de Koning, Eelco J. P.
   Carlotti, Francoise
TI Apolipoprotein L genes are novel mediators of inflammation in beta cells
SO DIABETOLOGIA
LA English
DT Article
DE Apolipoprotein L; Beta cells; Human islets; Inflammation
ID ENDOPLASMIC-RETICULUM STRESS; LIPID-BINDING PROTEIN; PLASMA
   TRIGLYCERIDES; APOPTOSIS; APOL1; IDENTIFICATION; HYPERGLYCEMIA;
   CYTOTOXICITY; ANTAGONIST; PANCREAS
AB Aims/hypothesisInflammation induces beta cell dysfunction and demise but underlying molecular mechanisms remain unclear. The apolipoprotein L (APOL) family of genes has been associated with innate immunity and apoptosis in non-pancreatic cell types, but also with metabolic syndrome and type 2 diabetes mellitus. Here, we hypothesised that APOL genes play a role in inflammation-induced beta cell damage.MethodsWe used single-cell transcriptomics datasets of primary human pancreatic islet cells to study the expression of APOL genes upon specific stress conditions. Validation of the findings was carried out in EndoC-beta H1 cells and primary human islets. Finally, we performed loss- and gain-of-function experiments to investigate the role of APOL genes in beta cells.ResultsAPOL genes are expressed in primary human beta cells and APOL1, 2 and 6 are strongly upregulated upon inflammation via the Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway. APOL1 overexpression increases endoplasmic reticulum stress while APOL1 knockdown prevents cytokine-induced beta cell death and interferon-associated response. Furthermore, we found that APOL genes are upregulated in beta cells from donors with type 2 diabetes compared with donors without diabetes mellitus.Conclusions/interpretationAPOLs are novel regulators of islet inflammation and may contribute to beta cell damage during the development of diabetes.Data availabilityscRNAseq data generated by our laboratory and used in this study are available in the Gene Expression Omnibus (GEO; www.ncbi.nlm.nih.gov/geo/), accession number GSE218316.
C1 [Paz-Barba, Miriam; Munoz Garcia, Amadeo; de Winter, Twan J. J.; de Graaf, Natascha; van Agen, Maarten; van der Sar, Elisa; Lambregtse, Ferdy; Daleman, Lizanne; de Koning, Eelco J. P.; Carlotti, Francoise] Leiden Univ Med Ctr, Dept Internal Med, Leiden, Netherlands.
   [van der Slik, Arno; Zaldumbide, Arnaud] Leiden Univ Med Ctr, Dept Cell & Chem Biol, Leiden, Netherlands.
C3 Leiden University; Leiden University Medical Center (LUMC); Leiden
   University; Leiden University Medical Center (LUMC)
RP Carlotti, F (corresponding author), Leiden Univ Med Ctr, Dept Internal Med, Leiden, Netherlands.
EM f.carlotti@lumc.nl
RI Zaldumbide, Arnaud/MTF-9065-2025; de Koning, Eelco/H-6030-2011;
   Carlotti, Françoise/H-1060-2014
OI de Winter, Twan/0000-0001-7230-3674; van der Slik,
   Arno/0000-0002-8920-0118
FU DON Foundation; Dutch Diabetes Research Foundation, JDRF; Bontius
   Foundation; Novo Nordisk Foundation Center for Stem Cell Medicine reNEW
   [NNF21CC0073729]
FX FC and EJPdK have received funding from the DON Foundation, the Dutch
   Diabetes Research Foundation, JDRF, the Bontius Foundation and the Novo
   Nordisk Foundation Center for Stem Cell Medicine reNEW (NNF21CC0073729).
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NR 47
TC 4
Z9 4
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0012-186X
EI 1432-0428
J9 DIABETOLOGIA
JI Diabetologia
PD JAN
PY 2024
VL 67
IS 1
BP 124
EP 136
DI 10.1007/s00125-023-06033-z
EA NOV 2023
PG 13
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA GC4Z5
UT WOS:001095787000001
PM 37924378
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Watanabe, Y
   Nessa, N
   Toba, H
   Kobara, M
   Nakata, T
AF Watanabe, Yusuke
   Nessa, Naseratun
   Toba, Hiroe
   Kobara, Miyuki
   Nakata, Tetsuo
TI Angelica acutiloba Exerts Antihypertensive Effect and Improves
   Insulin Resistance in Spontaneously Hypertensive Rats Fed with a
   High-Fat Diet
SO PHARMACOLOGY
LA English
DT Article
DE Angelica acutiloba; Spontaneously hypertensive rat; High-fat diet;
   Insulin resistance; Stress tolerance
ID CALCIUM-CHANNEL; FERULIC ACID; IN-VITRO; LIGUSTILIDE; DYSFUNCTION;
   SYSTEM; BUTYLIDENEPHTHALIDE; POLYACETYLENES; TELMISARTAN; ACTIVATION
AB Introduction: Angelica acutiloba is one of the crude drugs used in Chinese herbal medicine, and its intake is expected to improve metabolic syndrome-associated disorders. Here, we examined the effects of A. acutiloba extract (AAE) on hypertension and insulin resistance induced by the treatment of high-fat diet (HFD) to spontaneously hypertensive rats (SHRs). Then, we investigated the mechanisms associated with the effects of AAE. Methods: AAE was administered to HFD-fed SHRs. Systolic blood pressure (SBP), sympathetic nerve activity, hypothalamic angiotensin-converting enzyme (ACE) activity, blood glucose level, plasma insulin concentration, visceral fat mass, and gene expression of tumor necrosis factor-alpha (TNF-alpha) in the visceral fat were evaluated. Results: AAE reduced the increases in SBP and hypothalamic ACE activity observed in the HFD-fed SHRs, whereas the suppressive effect on sympathetic nerve activity was slight. Environmental stress-induced pressure and sympathetic overactivity were suppressed by the treatment of AAE. It also decreased the increase in the blood glucose level, plasma insulin concentration, homeostasis model assessment for the insulin resistance, and TNF-alpha gene expression in the visceral fat, but not the increase in the visceral fat mass. Conclusion: AAE has an antihypertensive effect, suppresses stress-induced hypertension, and improves insulin resistance in HFD-fed SHRs. The suppression of brain ACE activity, sympathetic nerve activity, and inflammation are partly involved in the effects of AAE.
C1 [Watanabe, Yusuke; Nessa, Naseratun; Toba, Hiroe; Kobara, Miyuki; Nakata, Tetsuo] Kyoto Pharmaceut Univ, Div Pathol Sci, Dept Clin Pharmacol, Kyoto, Japan.
C3 Kyoto Pharmaceutical University
RP Nakata, T (corresponding author), Kyoto Pharmaceut Univ, Div Pathol Sci, Dept Clin Pharmacol, Kyoto, Japan.
EM nakata@mb.kyoto-phu.ac.jp
FU Grants-in-Aid for Scientific Research [20K07300, 21K06606] Funding
   Source: KAKEN
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NR 42
TC 6
Z9 8
U1 3
U2 12
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0031-7012
EI 1423-0313
J9 PHARMACOLOGY
JI Pharmacology
PD MAR
PY 2022
VL 107
IS 3-4
BP 188
EP 196
DI 10.1159/000520982
EA JAN 2022
PG 9
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 9A5BB
UT WOS:000757379300001
PM 35038707
DA 2025-06-11
ER

PT J
AU Virtuoso, A
   Tveden-Nyborg, P
   Schou-Pedersen, AMV
   Lykkesfeldt, J
   Mueller, HK
   Elfving, B
   Sorensen, DB
AF Virtuoso, Alessandro
   Tveden-Nyborg, Pernille
   Schou-Pedersen, Anne Marie Voigt
   Lykkesfeldt, Jens
   Mueller, Heidi Kaastrup
   Elfving, Betina
   Sorensen, Dorte Bratbo
TI A Long-Term Energy-Rich Diet Increases Prefrontal BDNF in Sprague-Dawley
   Rats
SO NUTRIENTS
LA English
DT Article
DE BDNF; Cafeteria Diet; diet-induced obesity; experimental animal models
ID HIGH-FAT DIET; PERFORMANCE LIQUID-CHROMATOGRAPHY; OBJECT RECOGNITION
   MEMORY; PALATABLE CAFETERIA DIET; CHRONIC VARIABLE STRESS; OXIDATIVE
   STRESS; ENVIRONMENTAL ENRICHMENT; DEHYDROASCORBIC ACID; INDUCED OBESITY;
   NEURONAL PLASTICITY
AB Findings of the effect of high-fat feeding including "Cafeteria Diets" (CAF) on brain-derived neurotrophic factor (BDNF) in the hippocampus (HIP) and prefrontal cortex (PFC) in rodents are conflicting. CAF is a non-standardized, highly palatable energy-rich diet composed by everyday food items for human consumption and is known to induce metabolic syndrome and obesity in rats. However, the highly palatable nature of CAF may counteract a negative effect of chronic stress on anticipatory behavior and synaptic plasticity in the hippocampus, hence represent a confounding factor (e.g., when evaluating functional effects on the brain). This study investigated the effects of a chronic, restricted access to CAF on BDNF, monoamine neurotransmitters, and redox imbalance in HIP and PFC in male rats. Our results show that CAF induced BDNF and its receptor TrkB in PFC compared to the controls (p < 0.0005). No differences in monoamine neurotransmitters were detected in either PFC or HIP. CAF increased dehydroascorbic acid and decreased malondialdehyde in PFC (p < 0.05), suggesting an early redox imbalance insufficient to induce lipid peroxidation. This study supports that a chronic CAF on a restricted schedule increases BDNF levels in the PFC of rats, highlighting that this may be a suboptimal feeding regime when investigating the effects of diet-induced obesity in the brain and emphasizing this as a point of attention when comparing the findings.
C1 [Virtuoso, Alessandro; Tveden-Nyborg, Pernille; Schou-Pedersen, Anne Marie Voigt; Lykkesfeldt, Jens; Sorensen, Dorte Bratbo] Univ Copenhagen, Fac Hlth & Med Sci, Dept Vet & Anim Sci, DK-1870 Frederiksberg, Denmark.
   [Mueller, Heidi Kaastrup; Elfving, Betina] Aarhus Univ, Dept Clin Med, Translat Neuropsychiat Unit, DK-8000 Aarhus, Denmark.
C3 University of Copenhagen; Aarhus University
RP Sorensen, DB (corresponding author), Univ Copenhagen, Fac Hlth & Med Sci, Dept Vet & Anim Sci, DK-1870 Frederiksberg, Denmark.
EM a.virtuoso@hotmail.com; ptn@sund.ku.dk; amvoigt@gmail.com;
   jopl@sund.ku.dk; heidi.muller@clin.au.dk; betina.elfving@clin.au.dk;
   brat@sund.ku.dk
RI Elfving, Betina/H-2814-2019; Lykkesfeldt, Jens/A-1072-2011
OI Elfving, Betina/0000-0001-6939-5088; Tveden-Nyborg,
   Pernille/0000-0002-5574-5742; Kaastrup Muller,
   Heidi/0000-0002-9842-8114; Lykkesfeldt, Jens/0000-0002-6514-8407;
   Sorensen, Dorte Bratbo/0000-0002-6144-1710; Schou-Pedersen, Anne
   Marie/0000-0001-6375-8394
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NR 74
TC 7
Z9 7
U1 0
U2 6
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JAN
PY 2022
VL 14
IS 1
AR 126
DI 10.3390/nu14010126
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA YE5AS
UT WOS:000741138900001
PM 35011001
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Ajith, TA
AF Ajith, Thekkuttuparambil Ananthanarayanan
TI Role of mitochondria and mitochondria-targeted agents in non-alcoholic
   fatty liver disease
SO CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
LA English
DT Review
DE electron transport chain; mitochondrial DNA; mitochondrion;
   non-alcoholic fatty liver disease; non-alcoholic steatohepatitis;
   oxidative phosphorylation
ID TUMOR-NECROSIS-FACTOR; OXIDATIVE STRESS; VITAMIN-E; INSULIN-RESISTANCE;
   RESPIRATORY-CHAIN; NITRIC-OXIDE; METABOLIC SYNDROME; MOUSE HEPATOCYTES;
   TREATMENT OPTIONS; REACTIVE OXYGEN
AB Mitochondria play a pivotal role in the fatty acid oxidation and have been found to be affected early during the macrovesicular fat accumulation in the hepatocytes. The fatty infiltration is the primary cause of oxidative stress and inflammation in the non-alcoholic fatty liver disease (NAFLD), which can lead to the peroxidation of phospholipids, such as cardiolipin. Oxidative stress-induced damage to mitochondrial DNA can result in the impairment of oxidative phosphorylation and further increases the generation of reactive oxygen species. The mitochondrial damage may eventually lead to apoptotic death of hepatocytes. The apoptosis along with the generated cytokines from the stellate and Kupffer cells further augment the fibrotic changes to advance the disease. Hence, alleviation of the mitochondrial impairment, particularly in the early stages of NAFLD, may prevent the progression of the disease. Among the various experimentally studied mitochondrial-targeted agents, triphenylphosphonium cation ligated ubiquinone Q10 and vitamin E, Szeto-Scheller peptides, and superoxide dismutase mimetic-salen manganese complexes (EUK-8 and EUK-134) have been found to be most promising. In addition to these mitochondrial-targeted agents, a novel area of therapy called mitotherapy have also emerged. However, clinical studies conducted so far are still fragmentary to validate their efficacy. This review article discusses the mitochondria-targeted molecules and their potential role in the treatment of NAFLD.
C1 [Ajith, Thekkuttuparambil Ananthanarayanan] Amala Inst Med Sci, Dept Biochem, Trichur, Kerala, India.
RP Ajith, TA (corresponding author), Amala Inst Med Sci, Dept Biochem, Trichur, Kerala, India.
EM taajith@rediffmail.com
RI TA, Ajith/GZK-6147-2022
OI TA, Dr Ajith/0000-0002-9915-846X
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NR 107
TC 47
Z9 56
U1 2
U2 32
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0305-1870
EI 1440-1681
J9 CLIN EXP PHARMACOL P
JI Clin. Exp. Pharmacol. Physiol.
PD MAY
PY 2018
VL 45
IS 5
BP 413
EP 421
DI 10.1111/1440-1681.12886
PG 9
WC Pharmacology & Pharmacy; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Physiology
GA GC3TJ
UT WOS:000429706300001
PM 29112771
OA Bronze
DA 2025-06-11
ER

PT J
AU Broyles, ST
   Staiano, AE
   Drazba, KT
   Gupta, AK
   Sothern, M
   Katzmarzyk, PT
AF Broyles, Stephanie T.
   Staiano, Amanda E.
   Drazba, Kathryn T.
   Gupta, Alok K.
   Sothern, Melinda
   Katzmarzyk, Peter T.
TI Elevated C-Reactive Protein in Children from Risky Neighborhoods:
   Evidence for a Stress Pathway Linking Neighborhoods and Inflammation in
   Children
SO PLOS ONE
LA English
DT Article
ID ADULT SOCIOECONOMIC-STATUS; NUTRITION EXAMINATION SURVEY;
   CORONARY-HEART-DISEASE; BODY-MASS INDEX; CARDIOVASCULAR-DISEASE;
   METABOLIC SYNDROME; OLDER-ADULTS; PHYSICAL-ACTIVITY; HEALTH BEHAVIORS;
   NATIONAL-HEALTH
AB Background: Childhood socioeconomic status is linked to adult cardiovascular disease and disease risk. One proposed pathway involves inflammation due to exposure to a stress-inducing neighborhood environment. Whether CRP, a marker of systemic inflammation, is associated with stressful neighborhood conditions among children is unknown.
   Methods and Results: The sample included 385 children 5-18 years of age from 255 households and 101 census tracts. Multilevel logistic regression analyses compared children and adolescents with CRP levels >3 mg/L to those with levels <= 3 mg/L across neighborhood environments. Among children living in neighborhoods (census tracts) in the upper tertile of poverty or crime, 18.6% had elevated CRP levels, in contrast to 7.9% of children living in neighborhoods with lower levels of poverty and crime. Children from neighborhoods with the highest levels of either crime or poverty had 2.7 (95% CI: 1.2-6.2) times the odds of having elevated CRP levels when compared to children from other neighborhoods, independent of adiposity, demographic and behavioral differences.
   Conclusions: Children living in neighborhoods with high levels of poverty or crime had elevated CRP levels compared to children from other neighborhoods. This result is consistent with a psychosocial pathway favoring early development of cardiovascular risk that involves chronic stress from exposure to socially- and physically-disordered neighborhoods characteristic of poverty.
C1 [Broyles, Stephanie T.; Staiano, Amanda E.; Drazba, Kathryn T.; Gupta, Alok K.; Katzmarzyk, Peter T.] Louisiana State Univ Syst, Pennington Biomed Res Ctr, Baton Rouge, LA USA.
   [Sothern, Melinda] Louisiana State Univ, Hlth Sci Ctr, Sch Publ Hlth, New Orleans, LA USA.
C3 Louisiana State University System; Louisiana State University;
   Pennington Biomedical Research Center; Louisiana State University
   System; Louisiana State University Health Sciences Center New Orleans
RP Broyles, ST (corresponding author), Louisiana State Univ Syst, Pennington Biomed Res Ctr, Baton Rouge, LA USA.
EM stephanie.broyles@pbrc.edu
RI Broyles, Stephanie/C-8647-2011; Katzmarzyk, Peter/N-1974-2017; Staiano,
   Amanda/H-3956-2017
OI Gupta, Alok/0000-0002-0102-7155; Katzmarzyk, Peter/0000-0002-9280-6022;
   Staiano, Amanda/0000-0001-7846-046X
FU National Institutes of Health [RC1 DK086881]; American Heart Association
   [11GRNT7750027]; American Heart Association (AHA) [11GRNT7750027]
   Funding Source: American Heart Association (AHA)
FX This work was supported by National Institutes of Health grant RC1
   DK086881 (PTK) and American Heart Association grant 11GRNT7750027 (STB).
   The funders had no role in study design, data collection and analysis,
   decision to publish, or preparation of the manuscript.
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NR 90
TC 83
Z9 93
U1 1
U2 34
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD SEP 25
PY 2012
VL 7
IS 9
AR e45419
DI 10.1371/journal.pone.0045419
PG 8
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 016YP
UT WOS:000309556100047
PM 23049799
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Oliva, ME
   Cian, RE
   Ferreira, MD
   Garzon, AG
   Drago, SR
   D'Alessandro, ME
AF Oliva, Maria E.
   Cian, Raul E.
   Ferreira, Maria del Rosario
   Garzon, Antonela G. G.
   Drago, Silvina R. R.
   D'Alessandro, Maria E.
TI In vivo and in silico study of antioxidant and
   anti-inflammatory effects on the liver-spleen axis of microencapsulated
   brewers' spent grain peptides
SO FOOD & FUNCTION
LA English
DT Article
ID NONALCOHOLIC FATTY LIVER; ADIPOSE-TISSUE DYSFUNCTION; NF-KAPPA-B;
   OXIDATIVE STRESS; INFLAMMATORY CYTOKINES; PROTEIN; PATHOGENESIS;
   HYDROLYSATE; MECHANISMS; BALANCE
AB Metabolic syndrome (MS) is a cluster of risk factors for the development of cardiovascular disease and type 2 diabetes mellitus. Some dietary bioactive compounds such as peptides can exert dual antioxidant and anti-inflammatory effects. The aim of this study was to analyze the effects of microencapsulated brewers' spent grain peptides (BSG-P-MC) on hepatic injury, lipid peroxidation, oxidative stress and inflammation in the liver-spleen axis in Wistar rats fed with a sucrose-rich diet (SRD). Male rats received for 100 days a reference diet (RD), SRD or RD and SRD containing 700 mg per kg body weight per day of BSG-P-MC. The results demonstrated that BSG-P-MC reversed injury, lipid peroxidation, and oxidative stress in the liver. For the spleen, BSG-P-MC decreased the levels of lipid peroxidation, CAT activity, NF kappa B, PAI-1 and F4/80 protein mass levels with respect to the SRD-fed rats. Three peptides identified by LC-MS/MS from BSG-P-MC after in vitro gastrointestinal digestion showed high in silico free radical scavenging activity (LPRDPYVDPMAPLPR, ANLPRDPYVDPMAPLPRSGPE and ANLPRDPYVDPMAPLPR). Moreover, two identified peptides presented high in silico anti-inflammatory properties (LTIGDTVPNLELDSTHGKIR and VDPDEKDAQGQLPSRT). This study is the first report of antioxidant and anti-inflammatory properties of microencapsulated BSG-peptides exerted in the liver-spleen axis in a MS rodent model.
C1 [Oliva, Maria E.; Ferreira, Maria del Rosario; D'Alessandro, Maria E.] Univ Nacl Litoral, Fac Bioquim & Ciencias Biol, Lab Estudio Enfermedades Metab relacionadas con Nu, Santa Fe, Argentina.
   [Cian, Raul E.; Garzon, Antonela G. G.; Drago, Silvina R. R.] Univ Nacl Litoral, Fac Ingn Quim, Inst Tecnol Alimentos, Santa Fe, Argentina.
   [Oliva, Maria E.; Cian, Raul E.; Ferreira, Maria del Rosario; Garzon, Antonela G. G.; Drago, Silvina R. R.; D'Alessandro, Maria E.] Consejo Nacl Invest Cient & Tecn CONICET, Buenos Aires, Argentina.
C3 National University of the Littoral; National University of the
   Littoral; Consejo Nacional de Investigaciones Cientificas y Tecnicas
   (CONICET)
RP D'Alessandro, ME (corresponding author), Univ Nacl Litoral, Fac Bioquim & Ciencias Biol, Lab Estudio Enfermedades Metab relacionadas con Nu, Santa Fe, Argentina.; D'Alessandro, ME (corresponding author), Consejo Nacl Invest Cient & Tecn CONICET, Buenos Aires, Argentina.
EM medaless@fbcb.unl.edu.ar
RI Drago, Silvina/ABA-7446-2021; Oliva, Maria/IUM-4089-2023
OI Ferreira, Maria del Rosario/0000-0003-0760-9495; Drago,
   Silvina/0000-0002-9103-5991; D' Alessandro, Maria
   Eugenia/0000-0001-6008-5614; Oliva, Maria Eugenia/0000-0002-4368-4102
FU Agencia Santafesina de Ciencia, Tecnologia e Innovacion from Argentine
   [IO-2018-00046]
FX This work was supported by Agencia Santafesina de Ciencia, Tecnologia e
   Innovacion from Argentine (Project IO-2018-00046). The authors thank Bsc
   M.B. Vega Joubert for their technical assistance.
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NR 66
TC 4
Z9 4
U1 6
U2 27
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PD JUN 6
PY 2023
VL 14
IS 11
BP 5290
EP 5300
DI 10.1039/d2fo04104a
EA MAY 2023
PG 11
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA I1VW8
UT WOS:000988791300001
PM 37195630
DA 2025-06-11
ER

PT J
AU Cabus, U
   Kabukcu, C
   Fenkci, S
   Caner, V
   Oztekin, O
   Fenkci, V
   Enli, Y
AF Cabus, Umit
   Kabukcu, Cihan
   Fenkci, Semin
   Caner, Vildan
   Oztekin, Ozer
   Fenkci, Veysel
   Enli, Yasar
TI Serum Caspase-1 levels in women with polycystic ovary syndrome
SO TAIWANESE JOURNAL OF OBSTETRICS & GYNECOLOGY
LA English
DT Article
DE Caspase-1; IL-10; PCOS; Insulin resistance; Oxidative stress
ID INSULIN-RESISTANCE; OXIDATIVE STRESS; CHRONIC INFLAMMATION; METABOLIC
   SYNDROME; INTERLEUKIN-10; MEDIATORS; MECHANISM; GLUCOSE; RISK
AB Objective: Caspase-1 is implicated in several important inflammatory diseases and controls adipocyte differentiation and insulin sensitivity. Interleukin-10 (IL-10) is an anti-inflammatory cytokine and plays an important role in chronic inflammatory conditions. This study was planned to determine if there is any relationship between Caspase-1 and IL-10 levels in women with PCOS.
   Materials and methods: Forty-two women with PCOS and thirty-seven healthy controls were evaluated in this controlled clinical study. Caspase-1 and IL-10 levels, serum lipid sub-fractions, fasting glucose, fasting insulin and other hormones (gonadotropins, androgens), malondialdehyde (MDA) and glutathione (GSH) levels were measured. Homeostasis model assessment (HOMA-IR) was used to estimate insulin resistance.
   Results: Free androgen index (FAI), HOMA-IR, MDA and Caspase-1 levels were significantly higher in subjects with PCOS. However, the women with PCOS had considerably lower GSH concentration levels than healthy subjects. Serum IL-10 levels were higher in study subjects than in controls, though it was statistically insignificant. Caspase-1 was positively associated with IL-10.
   Conclusion: These outcomes propose that Caspase-1 may have a role in triggering the processes leading to chronic low-grade inflammation in women with PCOS, independent of insulin resistance, androgen excess and oxidative stress. Nevertheless, the precise role of Caspase-1 in the pathogenesis of the disease remains to be elucidated. (C) 2020 Taiwan Association of Obstetrics & Gynecology. Publishing services by Elsevier B.V.
C1 [Cabus, Umit; Kabukcu, Cihan; Oztekin, Ozer; Fenkci, Veysel] Pamukkale Univ, Sch Med, Dept Obstet & Gynecol, Denizli, Turkey.
   [Fenkci, Semin] Pamukkale Univ, Sch Med, Dept Internal Med, Div Endocrinol & Metab, Denizli, Turkey.
   [Caner, Vildan] Pamukkale Univ, Sch Med, Dept Med Genet, Denizli, Turkey.
   [Enli, Yasar] Pamukkale Univ, Sch Med, Dept Biochem, Denizli, Turkey.
C3 Pamukkale University; Pamukkale University; Pamukkale University;
   Pamukkale University
RP Oztekin, O (corresponding author), Yenisehir Mah,41-2 Sok Altinportakal Konutlari 4E, TR-20125 Denizli, Turkey.
EM ozeroztekin@gmail.com
RI Caner, Vildan/ABI-5029-2020; Kabukcu, Cihan/ADO-0931-2022; Enli,
   Yaşar/AAB-9154-2020
CR [Anonymous], POLYCYSTIC OVARY SYN
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NR 29
TC 12
Z9 12
U1 0
U2 6
PU ELSEVIER TAIWAN
PI TAIPEI
PA RM N-412, 4F, CHIA HSIN BUILDING 11, NO 96, ZHONG SHAN N ROAD SEC 2,
   TAIPEI, 10449, TAIWAN
SN 1028-4559
J9 TAIWAN J OBSTET GYNE
JI Taiwan. J. Obstet. Gynecol.
PD MAR
PY 2020
VL 59
IS 2
BP 207
EP 210
DI 10.1016/j.tjog.2020.01.007
PG 4
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA KS6BT
UT WOS:000518392900006
PM 32127139
OA gold
DA 2025-06-11
ER

PT J
AU Sagud, M
   Jaksic, N
   Vuksan-Cusa, B
   Loncar, M
   Loncar, I
   Peles, AM
   Milicic, D
   Jakovljevic, M
AF Sagud, Marina
   Jaksic, Nenad
   Vuksan-Cusa, Bjanka
   Loncar, Mladen
   Loncar, Ivana
   Peles, Alma Mihaljevic
   Milicic, Davor
   Jakovljevic, Miro
TI CARDIOVASCULAR DISEASE RISK FACTORS IN PATIENTS WITH POSTTRAUMATIC
   STRESS DISORDER (PTSD): A NARRATIVE REVIEW
SO PSYCHIATRIA DANUBINA
LA English
DT Review
DE PTSD; cardiovascular disease (CVD); CVD risk factors; personality;
   type-D personality-resilience; resilience enhancing strategies
ID CORONARY-HEART-DISEASE; NEUROTROPHIC FACTOR; WAR VETERANS;
   PERSONALITY-TRAITS; SOCIAL INHIBITION; PHYSICAL-ACTIVITY;
   MENTAL-DISORDERS; PLASMA-LEVELS; RESILIENCE; SYMPTOMS
AB Posttraumatic stress disorder (PTSD) is a chronic condition related to severe stress and trauma. There is a mounting evidence about increased prevalence and mortality from cardiovascular diseases (CVD) in patients with PTSD. This review summarizes the current data on possible relations between PTSD and increased risks of CVD, including biological, psychological and behavioral factors. Biological factors refer to increased prevalence of metabolic syndrome (MetS), hypertension, elevation of pro-inflammatory cytokines and homocysteine levels. Peripheral Brain-derived neurotropic factor (BDNF), serum N-terminal pro-brain natriuretic peptide (NT-proBNP) and quantitative electroencephalogram (qEEG) are promising surrogate markers of increased cardiovascular risk. Among psychological factors, some personality traits, such as neuroticism and trait impulsivity/hostility, contribute to the development of PTSD, and are associated with general cardiovascular distress. Recently, type-D (distressed) personality is usually investigated in relation to cardiovascular morbidity, but in populations other than PTSD patients. Behavioral factors refer to unhealthy life-styles, encompassing high smoking rate, drug substances abuse and addiction, physical inactivity and unhealthy diet. The relationships among all these factors are complex and yet incompletely taken into consideration. Because of a high prevalence of CVD in patients with PTSD, there is a strong need for a more intensive focus on this vulnerable population in both primary and secondary cardiovascular prevention as well as in effective treatment possibilities.
C1 [Sagud, Marina; Vuksan-Cusa, Bjanka; Loncar, Mladen; Peles, Alma Mihaljevic; Jakovljevic, Miro] Univ Zagreb, Univ Hosp Ctr Zagreb, Sch Med, Dept Psychiat, Zagreb, Croatia.
   [Jaksic, Nenad; Loncar, Ivana] Univ Hosp Ctr Zagreb, Dept Psychiat, Natl Ctr Psychotrauma, Kispaticeva 12, Zagreb 10000, Croatia.
   [Vuksan-Cusa, Bjanka] Univ Osijek, Sch Med, Osijek, Croatia.
   [Milicic, Davor] Univ Zagreb, Univ Hosp Ctr Zagreb, Sch Med, Dept Cardiovasc Dis, Zagreb, Croatia.
C3 University of Zagreb; UNIVERSITY ZAGREB HOSPITAL; University of Zagreb;
   UNIVERSITY ZAGREB HOSPITAL; University of JJ Strossmayer Osijek;
   University of Zagreb; UNIVERSITY ZAGREB HOSPITAL
RP Jaksic, N (corresponding author), Univ Hosp Ctr Zagreb, Dept Psychiat, Natl Ctr Psychotrauma, Kispaticeva 12, Zagreb 10000, Croatia.
EM nenad_jaksic@yahoo.com
RI Milicic, Davor/U-4225-2019; Jaksic, Nenad/JQI-6576-2023; Sagud,
   Marina/G-1265-2015
OI Jaksic, Nenad/0000-0002-5286-720X; Sagud, Marina/0000-0001-9620-2181
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NR 109
TC 23
Z9 25
U1 0
U2 23
PU MEDICINSKA NAKLADA
PI ZAGREB
PA VLASKA 69, HR-10000 ZAGREB, CROATIA
SN 0353-5053
J9 PSYCHIAT DANUB
JI Psychiatr. Danub.
PY 2017
VL 29
IS 4
BP 421
EP 430
DI 10.24869/psyd.2017.421
PG 10
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA FP9WI
UT WOS:000417999500004
PM 29197198
OA Green Published
DA 2025-06-11
ER

PT J
AU Sharma, V
   Mehdi, MM
AF Sharma, Vinita
   Mehdi, Mohammad Murtaza
TI Oxidative stress, inflammation and hormesis: The role of dietary and
   lifestyle modifications on aging
SO NEUROCHEMISTRY INTERNATIONAL
LA English
DT Article
DE Aging; Oxidative stress and free radicals; Age -related diseases and
   inflammaging; Hormesis; Calorie restriction; Physical activity and
   nutrition
ID GLYCATION END-PRODUCTS; FREE-RADICAL THEORY; CALORIC RESTRICTION;
   LIPID-PEROXIDATION; PROTEIN OXIDATION; NITRIC-OXIDE; DNA-DAMAGE;
   MEDITERRANEAN DIET; METABOLIC SYNDROME; HEAT-SHOCK
AB Oxidative stress (OS) is primarily caused by the formation of free radicals and reactive oxygen species; it is considered as one of the prominent factors in slowing down and degrading cellular machinery of an individual, and it eventually leads to aging and age-related diseases by its continuous higher state. The relation between molecular damage and OS should be particularized to understand the beginning of destruction at the cellular levels, extending outwards to affect tissues, organs, and ultimately to the organism. Several OS biomarkers, which are established at the biomolecular level, are useful in investigating the disease susceptibility during aging. Slowing down the aging process is a matter of reducing the rate of oxidative damage to the cellular machinery over time. The breakdown of homeostasis, the mild overcompensation, the reestablishment of ho-meostasis, and the adaptive nature of the process are the essential features of hormesis, which incorporates several factors, including calorie restriction, nutrition and lifestyle modifications that play an important role in reducing the OS. In the current review, along with the concept and theories of aging (with emphasis on free radical theory), various manifestations of OS with special attention on mitochondrial dysfunction and age-related diseases have been discussed. To alleviate the OS, hormetic approaches including caloric restriction, exercise, and nutrition have also been discussed.
C1 [Sharma, Vinita; Mehdi, Mohammad Murtaza] Lovely Profess Univ, Sch Bioengn & Biosci, Phagwara 144401, Punjab, India.
   [Mehdi, Mohammad Murtaza] Lovely Profess Univ, Lovely Fac Technol & Sci, Sch Bioengn & Biosci, Dept Biochem, Phagwara 144401, Punjab, India.
C3 Lovely Professional University; Lovely Professional University
RP Mehdi, MM (corresponding author), Lovely Profess Univ, Lovely Fac Technol & Sci, Sch Bioengn & Biosci, Dept Biochem, Phagwara 144401, Punjab, India.
EM mehdibiochem@gmail.com
OI Mehdi, Mohammad/0000-0002-0988-0425
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NR 277
TC 46
Z9 50
U1 23
U2 74
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0197-0186
EI 1872-9754
J9 NEUROCHEM INT
JI Neurochem. Int.
PD MAR
PY 2023
VL 164
AR 105490
DI 10.1016/j.neuint.2023.105490
EA JAN 2023
PG 21
WC Biochemistry & Molecular Biology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Neurosciences & Neurology
GA 8Q9AE
UT WOS:000927490200001
PM 36702401
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Trnovska, J
   Svoboda, P
   Pelantova, H
   Kuzma, M
   Kratochvilova, H
   Kasperova, BJ
   Dvorakova, I
   Rosolova, K
   Malinska, H
   Huttl, M
   Markova, I
   Oliyarnyk, O
   Melcova, M
   Skop, V
   Mraz, M
   Stemberkova-Hubackova, S
   Haluzik, M
AF Trnovska, Jaroslava
   Svoboda, Petr
   Pelantova, Helena
   Kuzma, Marek
   Kratochvilova, Helena
   Kasperova, Barbora Judita
   Dvorakova, Iveta
   Rosolova, Katerina
   Malinska, Hana
   Huttl, Martina
   Markova, Irena
   Oliyarnyk, Olena
   Melcova, Magdalena
   Skop, Vojtech
   Mraz, Milos
   Stemberkova-Hubackova, Sona
   Haluzik, Martin
TI Complex Positive Effects of SGLT-2 Inhibitor Empagliflozin in the Liver,
   Kidney and Adipose Tissue of Hereditary Hypertriglyceridemic Rats:
   Possible Contribution of Attenuation of Cell Senescence and Oxidative
   Stress
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE empagliflozin; metabolic syndrome; hypertriglyceridemia; insulin
   sensitivity; cell senescence; hereditary hypertriglyceridemic rat model
ID COTRANSPORTER 2 INHIBITOR; GLUCOSE-HOMEOSTASIS; INSULIN-RESISTANCE; HEME
   OXYGENASE-1; GENE-EXPRESSION; IMPROVES; INFLAMMATION; DIFFERENTIATION;
   HYPERGLYCEMIA; MACROPHAGES
AB (1) Background: empagliflozin, sodium-glucose co-transporter 2 (SGLT-2) inhibitor, is an effective antidiabetic agent with strong cardio- and nephroprotective properties. The mechanisms behind its cardio- and nephroprotection are still not fully clarified. (2) Methods: we used male hereditary hypertriglyceridemic (hHTG) rats, a non-obese model of dyslipidaemia, insulin resistance, and endothelial dysfunction fed standard diet with or without empagliflozin for six weeks to explore the molecular mechanisms of empagliflozin effects. Nuclear magnetic resonance (NMR)-based metabolomics; quantitative PCR of relevant genes involved in lipid and glucose metabolism, or senescence; glucose and palmitic acid oxidation in isolated tissues and cell lines of adipocytes and hepatocytes were used. (3) Results: empagliflozin inhibited weight gain and decreased adipose tissue weight, fasting blood glucose, and triglycerides and increased HDL-cholesterol. It also improved insulin sensitivity in white fat. NMR spectroscopy identified higher plasma concentrations of ketone bodies, ketogenic amino acid leucine and decreased levels of pyruvate and alanine. In the liver, adipose tissue and kidney, empagliflozin up-regulated expression of genes involved in gluconeogenesis and down-regulated expression of genes involved in lipogenesis along with reduction of markers of inflammation, oxidative stress and cell senescence. (4) Conclusion: multiple positive effects of empagliflozin, including reduced cell senescence and oxidative stress, could contribute to its long-term cardio- and nephroprotective actions.
C1 [Trnovska, Jaroslava; Svoboda, Petr; Kratochvilova, Helena; Dvorakova, Iveta; Malinska, Hana; Huttl, Martina; Markova, Irena; Oliyarnyk, Olena; Skop, Vojtech] Inst Clin & Expt Med, Ctr Med Expt, Cardiometabol Res Div, Prague 14021, Czech Republic.
   [Svoboda, Petr; Rosolova, Katerina; Melcova, Magdalena; Skop, Vojtech] Univ Chem Technol, Dept Biochem & Microbiol, Lab Anim Biochem, Prague 16628, Czech Republic.
   [Kuzma, Marek] Czech Acad Sci, Inst Microbiol, Lab Mol Struct Characterizat, Prague 14220, Czech Republic.
   [Kuzma, Marek] Palacky Univ Olomouc, Fac Sci, Dept Analyt Chem, Olomouc 77900, Czech Republic.
   [Kasperova, Barbora Judita; Rosolova, Katerina; Mraz, Milos; Haluzik, Martin] Inst Clin & Expt Med, Ctr Diabet, Prague 14021, Czech Republic.
   [Stemberkova-Hubackova, Sona] Czech Acad Sci, Inst Biotechnol, Lab Mol Therapy, Prague 25250, Czech Republic.
   [Haluzik, Martin] Charles Univ Prague, Fac Med 1, Inst Med Biochem & Lab Diagnost, Prague 12808, Czech Republic.
   [Haluzik, Martin] Gen Univ Hosp, Prague 12808, Czech Republic.
C3 Institute for Clinical & Experimental Medicine (IKEM); University of
   Chemistry & Technology, Prague; Czech Academy of Sciences; Institute of
   Microbiology of the Czech Academy of Sciences; Palacky University
   Olomouc; Institute for Clinical & Experimental Medicine (IKEM); Czech
   Academy of Sciences; Institute of Biotechnology of the Czech Academy of
   Sciences; Charles University Prague; General University Hospital Prague
RP Trnovska, J (corresponding author), Inst Clin & Expt Med, Ctr Med Expt, Cardiometabol Res Div, Prague 14021, Czech Republic.; Haluzik, M (corresponding author), Inst Clin & Expt Med, Ctr Diabet, Prague 14021, Czech Republic.; Haluzik, M (corresponding author), Charles Univ Prague, Fac Med 1, Inst Med Biochem & Lab Diagnost, Prague 12808, Czech Republic.; Haluzik, M (corresponding author), Gen Univ Hosp, Prague 12808, Czech Republic.
EM jaroslava.trnovska@ikem.cz; svobodae@vscht.cz; pelantova@biomed.cas.cz;
   kuzma@biomed.cas.cz; helena.kratochvilova@ikem.cz;
   barbora.judita.kasperova@ikem.cz; iveta.dvorakova@ikem.cz;
   katerina.rosolova@ikem.cz; hana.malinska@ikem.cz; martina.huttl@ikem.cz;
   irena.markova@ikem.cz; ooliyarnyk@yahoo.com; melcovam@vscht.cz;
   vojtech.skop@nih.gov; milos.mraz@ikem.cz; stemberkova@ibt.cas.cz;
   martin.haluzik@ikem.cz
RI Mraz, Milos/S-5243-2016; Pelantová, Helena/R-4974-2017; Kuzma,
   Marek/F-5468-2015; Oliyarnyk, Olena/Q-6380-2019; Haluzik,
   Martin/I-8190-2017; Dvorakova, Iveta/H-7061-2017; Svoboda,
   Petr/B-7865-2014; Kratochvilova, Helena/I-3450-2017; Skop,
   Vojtech/LBI-2231-2024
OI Markova, Irena/0000-0002-4331-7636; Dvorakova,
   Iveta/0000-0002-6894-1558; Svoboda, Petr/0000-0001-7297-4208;
   Kratochvilova, Helena/0000-0001-8264-3883; Skop,
   Vojtech/0000-0002-4685-4429
FU Czech Science Foundation [GA19-06199S]; CZDRO (Institute for Clinical
   and Experimental MedicineIKEM) [00023001]; RVO VFN [64165]
FX This study was supported by grants from the Czech Science Foundation
   (GA19-06199S), by CZDRO (Institute for Clinical and Experimental
   MedicineIKEM, IN 00023001) and by RVO VFN 64165 to M.H. (Martin
   Haluzik).
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NR 84
TC 19
Z9 19
U1 2
U2 26
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD OCT
PY 2021
VL 22
IS 19
AR 10606
DI 10.3390/ijms221910606
PG 23
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA WI0EZ
UT WOS:000708042200001
PM 34638943
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Hou, C
   Wang, YY
   Zhu, EK
   Yan, CH
   Zhao, L
   Wang, XJ
   Qiu, YF
   Shen, H
   Sun, XJ
   Feng, ZH
   Liu, JK
   Long, JG
AF Hou, Chen
   Wang, Yongyao
   Zhu, Erkang
   Yan, Chunhong
   Zhao, Lin
   Wang, Xiaojie
   Qiu, Yingfeng
   Shen, Hui
   Sun, Xuejun
   Feng, Zhihui
   Liu, Jiankang
   Long, Jiangang
TI Coral calcium hydride prevents hepatic steatosis in high fat
   diet-induced obese rats: A potent mitochondrial nutrient and phase II
   enzyme inducer
SO BIOCHEMICAL PHARMACOLOGY
LA English
DT Article
DE Coral calcium hydride; HFD; Mitochondria; Nonalcoholic fatty liver
   disease; Phase II enzyme
ID PIGMENT EPITHELIAL-CELLS; ISCHEMIA-REPERFUSION INJURY; GOTO-KAKIZAKI
   RATS; LIVER-DISEASE; OXIDATIVE STRESS; NONALCOHOLIC STEATOHEPATITIS;
   INSULIN-RESISTANCE; GLUCOSE-METABOLISM; MOLECULAR-HYDROGEN;
   SKELETAL-MUSCLE
AB Diet-induced nonalcoholic fatty liver disease (NAFLD) is characterized by profound lipid accumulation and associated with an inflammatory response, oxidative stress and hepatic mitochondrial dysfunction. We previously demonstrated that some mitochondrial nutrients effectively ameliorated high fat diet (HFD)-induced hepatic steatosis and metabolic disorders. Molecular hydrogen in hydrogen-rich liquid or inhaling gas, which has been confirmed in scavenging reactive oxygen species and preventing mitochondrial decay, improved metabolic syndrome in patients and animal models. Coral calcium hydride (CCH) is a new solid molecular hydrogen carrier made of coral calcium. However, whether and how CCH impacts HFD-induced hepatic steatosis remains uninvestigated. In the present study, we applied CCH to a HFD-induced NAFLD rat model for 13 weeks. We found that CCH durably generated hydrogen in vivo and in vitro. CCH treatment significantly reduced body weight gain, improved glucose and lipid metabolism and attenuated hepatic steatosis in HFD-induced obese rats with no influence on food and water intake. Moreover, CCH effectively improved HFD-induced hepatic mitochondrial dysfunction, reduced oxidative stress, and activated phase II enzymes. Our results suggest that CCH is an efficient hydrogen-rich agent, which could prevent HFD-induced NAFLD via activating phase II enzymes and improving mitochondrial function. (C) 2016 Elsevier Inc. All rights reserved.
C1 [Hou, Chen; Wang, Yongyao; Zhu, Erkang; Yan, Chunhong; Zhao, Lin; Wang, Xiaojie; Qiu, Yingfeng; Feng, Zhihui; Liu, Jiankang; Long, Jiangang] Xi An Jiao Tong Univ, Ctr Mitochondrial Biol & Med, Xian 710049, Peoples R China.
   [Hou, Chen; Wang, Yongyao; Zhu, Erkang; Yan, Chunhong; Zhao, Lin; Wang, Xiaojie; Qiu, Yingfeng; Feng, Zhihui; Liu, Jiankang; Long, Jiangang] Xi An Jiao Tong Univ, Sch Life Sci & Technol, Minist Educ, Key Lab Biomed Informat Engn, Xian 710049, Peoples R China.
   [Hou, Chen; Wang, Yongyao; Zhu, Erkang; Yan, Chunhong; Zhao, Lin; Wang, Xiaojie; Qiu, Yingfeng; Feng, Zhihui; Liu, Jiankang; Long, Jiangang] Xi An Jiao Tong Univ, Frontier Inst Sci & Technol, Xian 710049, Peoples R China.
   [Shen, Hui] Second Mil Med Univ, Dept Mil Hyg, Shanghai 200433, Peoples R China.
   [Sun, Xuejun] Second Mil Med Univ, Dept Aeromed, Shanghai 200433, Peoples R China.
C3 Xi'an Jiaotong University; Ministry of Education - China; Xi'an Jiaotong
   University; Xi'an Jiaotong University; Naval Medical University; Naval
   Medical University
RP Liu, JK; Long, JG (corresponding author), Xi An Jiao Tong Univ, Ctr Mitochondrial Biol & Med, Sch Life Sci & Technol, Xian 710049, Peoples R China.
EM j.liu@mail.xjtu.edu.cn; jglong@mail.xjtu.edu.cn
RI Wang, Hongfeng/H-1807-2016; Long, Jiangang/A-7835-2015; sun,
   xuejun/A-5561-2010; HOU, CHEN/IQT-3648-2023; Wang, Yongyao/Q-2269-2016;
   Zhao, Lin/AHD-2506-2022; Liu, Jiankang/A-1610-2011; Feng,
   Zhihui/E-7408-2011
OI Feng, Zhihui/0000-0002-2448-6565; , Lin Zhao/0000-0002-6056-8787; Sun,
   Xuejun/0000-0003-2387-5531; Jiangang, Long/0000-0001-8074-957X
FU 973 Program [2015CB856302, 2015CB553602]; Fundamental Research Funds for
   the Central Universities [08143008, 08143101]
FX This work was supported by the 973 Program (2015CB856302, 2015CB553602)
   and the Fundamental Research Funds for the Central Universities
   (08143008, 08143101). We thank that CC and CCH were provided by The
   Institute for Creative Biotechnology, Sendai, Japan and Shanghai Quanren
   Bioscience and Technology Co, Ltd, Shanghai, China.
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NR 52
TC 29
Z9 35
U1 0
U2 38
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0006-2952
EI 1873-2968
J9 BIOCHEM PHARMACOL
JI Biochem. Pharmacol.
PD MAR 1
PY 2016
VL 103
BP 85
EP 97
DI 10.1016/j.bcp.2015.12.020
PG 13
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA DH5UW
UT WOS:000372858600008
PM 26774456
DA 2025-06-11
ER

PT J
AU Mukai, Y
   Norikura, T
   Fujita, S
   Mikame, K
   Funaoka, M
   Sato, S
AF Mukai, Yuuka
   Norikura, Toshio
   Fujita, Shuzo
   Mikame, Keigo
   Funaoka, Masamitsu
   Sato, Shin
TI Effect of lignin-derived lignophenols on vascular oxidative stress and
   inflammation in streptozotocin-induced diabetic rats
SO MOLECULAR AND CELLULAR BIOCHEMISTRY
LA English
DT Article
DE Lignophenols; Superoxide production; NAD(P)H oxidase; Monocyte
   chemoattractant protein-1; Diabetic rats
ID MONOCYTE CHEMOATTRACTANT PROTEIN-1; NAD(P)H OXIDASE; NADPH OXIDASE;
   ENDOTHELIAL DYSFUNCTION; METABOLIC SYNDROME; ACTIVATION; CELLS;
   COMPLICATIONS; NEPHROPATHY; EXPRESSION
AB Lignophenols (LP) are the derivatives of native lignin, which is an abundant organic polymer in the plant kingdom. This study investigated whether LP can attenuate vascular oxidative stress and inflammation in streptozotocin (STZ)-induced diabetic rats. The diabetic rats induced by a single intravenous injection of STZ were randomly divided into two groups fed either 0 or 1.0% LP-containing diet. After 5 weeks of treatment, the superoxide (O-2 (-)) production, mRNA expression levels of nicotinamide adenine dinucleotide (phosphate) (NAD(P)H) oxidase subunits, monocyte chemoattractant protein-1 (MCP-1) and its receptor C-C chemokine receptor 2 (CCR2), and protein expression level of inducible nitric oxide synthase (iNOS) were examined in the aorta of vehicle-injected control and diabetic rats treated with or without LP. The increased O-2 (-) production and mRNA expression levels of NAD(P)H oxidase subunits Nox4 and p47phox were found to be significantly reduced in the aorta of diabetic rats treated with LP. The mRNA expression of MCP-1 and CCR2, and the protein expression of iNOS were found to be increased in the aorta of untreated diabetic rats, whereas these levels were significantly lower in the LP-treated group. These findings suggest that LP could attenuate vascular oxidative stress and/or inflammation via inhibition of NAD(P)H oxidase. This may lead to an improvement in the vascular impairment of diabetes.
C1 [Mukai, Yuuka; Norikura, Toshio; Fujita, Shuzo; Sato, Shin] Aomori Univ Hlth & Welf, Fac Hlth Sci, Dept Nutr, Aomori 0308505, Japan.
   [Mikame, Keigo; Funaoka, Masamitsu] Mie Univ, Grad Sch Bioresources, Tsu, Mie 5148507, Japan.
C3 Aomori University of Health & Welfare; Mie University
RP Sato, S (corresponding author), Aomori Univ Hlth & Welf, Fac Hlth Sci, Dept Nutr, Mase 58-1, Aomori 0308505, Japan.
EM s_sato3@auhw.ac.jp
FU Grants-in-Aid for Scientific Research [23500960, 21700760] Funding
   Source: KAKEN
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NR 37
TC 17
Z9 17
U1 0
U2 16
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0300-8177
EI 1573-4919
J9 MOL CELL BIOCHEM
JI Mol. Cell. Biochem.
PD FEB
PY 2011
VL 348
IS 1-2
BP 117
EP 124
DI 10.1007/s11010-010-0645-9
PG 8
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA 703JC
UT WOS:000285973200013
PM 21063899
DA 2025-06-11
ER

PT J
AU Tolan, NV
   Genes, LI
   Subasinghe, W
   Raththagala, M
   Spence, DM
AF Tolan, Nicole V.
   Genes, Luiza I.
   Subasinghe, Wasanthi
   Raththagala, Madushi
   Spence, Dana M.
TI Personalized Metabolic Assessment of Erythrocytes Using Microfluidic
   Delivery to an Array of Luminescent Wells
SO ANALYTICAL CHEMISTRY
LA English
DT Article
ID RED-BLOOD-CELLS; DEPENDENT DIABETES-MELLITUS; ATP RELEASE; GLUTATHIONE;
   POLY(DIMETHYLSILOXANE); PATHWAY; SYSTEMS;
   GLUCOSE-6-PHOSPHATE-DEHYDROGENASE; MICROFABRICATION; ELECTROPHORESIS
AB The metabolic syndrome is often described as a group of risk factors associated with diabetes. These risk factors include, but are not limited to, such conditions as insulin resistance, obesity, high blood pressure, and oxidant stress. Here, we report on a tool that may provide some clarity on the relationship between some of these associated risk factors, especially oxidant stress and hypertension. Specifically, we describe the ability to simultaneously monitor nicotinamide dinucleotide phosphate (NADPH), reduced glutathione (GSH), and shear-induced adenosine triphosphate (ATP) release from erythrocytes using luminescence detection on a microfabricated device. The measurements are performed by delivering erythrocyte lysate (for the NADPH and GSH measurements, two analytes indicative of oxidative stress) or whole red blood cells (RBCs) (for the determination of ATP release from the cells) to an array of wells that contain the necessary reagents to generate a luminescence emission that is proportional to analyte concentration. A fluorescence macrostereomicroscope enables whole-chip imaging of the resultant emission. The concentrations of each NADPH and GSH contained within a 0.7% erythrocyte solution were determined to be 31.06 +/- 4.12 and 22.55 +/- 2.47 mu M, respectively, and the average ATP released from a nonlysed 7% erythrocyte solution was determined to be 0.54 +/- 0.04 mu M. Collectively, the device represents a precursor to subsequent merging of microfluidics and microtiter-plate technology for high-throughput assessment of metabolite profiles in the diabetic erythrocyte.
C1 [Tolan, Nicole V.; Genes, Luiza I.; Subasinghe, Wasanthi; Raththagala, Madushi; Spence, Dana M.] Michigan State Univ, Dept Chem, E Lansing, MI 48824 USA.
C3 Michigan State University
RP Spence, DM (corresponding author), Michigan State Univ, Dept Chem, E Lansing, MI 48824 USA.
EM dspence@chemistry.msu.edu
RI Raththagala, Madushi/AAU-5254-2020
OI Subasinghe, Wasanthi/0000-0003-3847-0852; Tolan,
   Nicole/0000-0002-7239-1843
FU National Institutes of Health [R01 DK071888-01A2]; Michigan State
   University
FX This work was funded by the National Institutes of Health (NIDDK R01
   DK071888-01A2) and Michigan State University.
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NR 34
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U1 0
U2 23
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0003-2700
EI 1520-6882
J9 ANAL CHEM
JI Anal. Chem.
PD APR 15
PY 2009
VL 81
IS 8
BP 3102
EP 3108
DI 10.1021/ac900084g
PG 7
WC Chemistry, Analytical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry
GA 432UD
UT WOS:000265158800036
PM 19301907
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Vergès, B
AF Verges, Bruno
TI Cardiovascular disease in type 1 diabetes, an underestimated danger:
   Epidemiological and pathophysiological data
SO ATHEROSCLEROSIS
LA English
DT Review
DE Cardiovascular disease; Type 1 diabetes; Atherosclerosis; Hyperglycemia;
   Lipid
ID CORONARY-ARTERY CALCIFICATION; GLYCATION END-PRODUCTS; ALL-CAUSE
   MORTALITY; PROTEIN-KINASE-C; CHOLESTERYL ESTER TRANSFER; OXIDATIVE
   STRESS; COMPLICATIONS-TRIAL/EPIDEMIOLOGY; PITTSBURGH EPIDEMIOLOGY;
   GLYCEMIC VARIABILITY; METABOLIC SYNDROME
AB Cardiovascular disease (CV) is a common complication of type 1 diabetes (T1D) and a leading cause of death. T1D patients are more likely to develop CV disease (CVD) early in life and show a reduction of life expectancy of at least 11 years. Patients with a young age of T1D onset have a substantially higher CV risk. The reasons for increased atherosclerosis in T1D patients are not entirely explained. In addition to the typical CV risk factors, long-term hyperglycemia has a significant impact by inducing oxidative stress, vascular inflammation, monocyte adhesion, arterial wall thickening and endothelial dysfunction. Additionally, CVD in T1D is also associated with nephropathy. However, CVD risk is still significantly increased in T1D patients, in good glycemic control without additional CV risk factors, indicating the involvement of supplementary potential factors. By increasing oxidative stress, vascular inflammation, and endothelial dysfunction, hypoglycemia and glucose variability may exacerbate CVD. Moreover, significant qualitative and functional abnormalities of lipoproteins are present in even wellcontrolled T1D patients and are likely to play a role in the development of atherosclerosis and the promotion of CVD. According to recent research, immune system dysfunction, which is typical of auto -immune T1D, may also promote CVD, likely via inflammatory pathways. In addition, T1D patients who are overweight or obese exhibit an additional CV risk due to pathophysiological mechanisms that are similar to those seen in T2D.
C1 [Verges, Bruno] Dijon Univ Hosp, Endocrinol Diabetol Dept, Dijon, France.
   [Verges, Bruno] Med Univ, INSERM LNC UMR1231, F-21000 Dijon, France.
   [Verges, Bruno] CHU Dijon, Serv Endocrinol Diabetol & Malad Metab, 14 Rue Gaffarel, F-21000 Dijon, France.
C3 Universite Bourgogne Europe; CHU Dijon Bourgogne; Institut National de
   la Sante et de la Recherche Medicale (Inserm); Universite Bourgogne
   Europe; Institut Agro; AgroSup Dijon; Universite Bourgogne Europe; CHU
   Dijon Bourgogne
RP Vergès, B (corresponding author), Dijon Univ Hosp, Endocrinol Diabetol Dept, Dijon, France.; Vergès, B (corresponding author), Med Univ, INSERM LNC UMR1231, F-21000 Dijon, France.; Vergès, B (corresponding author), CHU Dijon, Serv Endocrinol Diabetol & Malad Metab, 14 Rue Gaffarel, F-21000 Dijon, France.
EM bruno.verges@chu-dijon.fr
RI Vergès, Bruno/G-9466-2012
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NR 124
TC 24
Z9 25
U1 9
U2 13
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0021-9150
EI 1879-1484
J9 ATHEROSCLEROSIS
JI Atherosclerosis
PD JUL
PY 2024
VL 394
AR 117158
DI 10.1016/j.atherosclerosis.2023.06.005
EA JUN 2024
PG 10
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA WG5M4
UT WOS:001253729800001
PM 37369617
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Morera, P
   Basiricò, L
   Hosoda, K
   Bernabucci, U
AF Morera, Patrizia
   Basirico, Loredana
   Hosoda, Kenji
   Bernabucci, Umberto
TI Chronic heat stress up-regulates leptin and adiponectin secretion and
   expression and improves leptin, adiponectin and insulin sensitivity in
   mice
SO JOURNAL OF MOLECULAR ENDOCRINOLOGY
LA English
DT Article
ID CALORIC RESTRICTION; GENE-EXPRESSION; ADIPOSE-TISSUE; METABOLIC
   SYNDROME; HYPERTHERMIA; ADIPOKINES; RESISTANCE; MUSCLE; EXPOSURE;
   GLUCOSE
AB Heat stress (HS) induces adaptive responses that are responsible for alterations of carbohydrate and lipid metabolism. This study aimed to evaluate the effects of chronic heat treatment on the expression and secretion of leptin and adiponectin, important regulators of energy homeostasis, food intake and insulin action. C57BL/6 mice were subdivided into three groups (24 mice each). The first group was kept under control conditions (C: 22 +/- 2 degrees C). The second group was exposed to HS (35 +/- 1 degrees C). The third group was kept under control conditions and was food restricted (FR). The HS group had higher rectal temperature than the C and FR groups and lower food intake than the C group. Hspa1 (Hspa1a) gene expression in adipose tissue, muscle and liver was higher under HS than FR and C. Heat treatment resulted in decreased blood glucose and non-esterified fatty acids; increased leptin, adiponectin and insulin secretion; and greater glucose disposal. Leptin, adiponectin, leptin and adiponectin receptors, insulin receptor substrate-1 and glucose transporter mRNAs were up-regulated in HS mice. This study provides evidence that HS improves leptin and adiponectin signalling in adipose tissue, muscle and liver. Heat stress was responsible for improving insulin sensitivity and glucose uptake in peripheral tissues, probably mediated by adipokines. Changes in the adipokine levels and sensitivity to them may be considered as an adaptive response to heat. Journal of Molecular Endocrinology (2012) 48, 129-138
C1 [Morera, Patrizia; Basirico, Loredana; Bernabucci, Umberto] Univ Tuscia, Dept Agr Forestry Nat & Energy, SNC, I-01100 Viterbo, Italy.
C3 Tuscia University
RP Bernabucci, U (corresponding author), Univ Tuscia, Dept Agr Forestry Nat & Energy, SNC, Via San Camillo De Lellis, I-01100 Viterbo, Italy.
EM bernab@unitus.it
RI Bernabucci, Umberto/C-7746-2011
OI Bernabucci, Umberto/0000-0002-8126-3042; BASIRICO',
   Loredana/0000-0002-4738-3622
FU Italian Government - Ministry of University and Research
FX This work was supported by funding from Italian Government - Ministry of
   University and Research (PRIN-2007).
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U1 3
U2 30
PU BIOSCIENTIFICA LTD
PI BRISTOL
PA EURO HOUSE, 22 APEX COURT WOODLANDS, BRADLEY STOKE, BRISTOL BS32 4JT,
   ENGLAND
SN 0952-5041
J9 J MOL ENDOCRINOL
JI J. Mol. Endocrinol.
PD APR
PY 2012
VL 48
IS 2
BP 129
EP 138
DI 10.1530/JME-11-0054
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 938VS
UT WOS:000303762100005
PM 22279186
OA Bronze
DA 2025-06-11
ER

PT J
AU Lockyer, S
   de la Hunty, AE
   Steenson, S
   Spiro, A
   Stanner, SA
AF Lockyer, Stacey
   de la Hunty, Anne E.
   Steenson, Simon
   Spiro, Ayela
   Stanner, Sara A.
TI Walnut consumption and health outcomes with public health relevance-a
   systematic review of cohort studies and randomized controlled trials
   published from 2017 to present
SO NUTRITION REVIEWS
LA English
DT Review
DE cardiovascular disease; public health; systematic review; walnuts
ID CARDIOVASCULAR RISK-FACTORS; METABOLIC SYNDROME STATUS; TREE NUT
   CONSUMPTION; ALL-CAUSE MORTALITY; GUT MICROBIOTA; BLOOD-LIPIDS;
   COGNITIVE FUNCTION; NUTRIENT INTAKE; HYPERCHOLESTEROLEMIC MEN;
   DIFFERENTIALLY AFFECT
AB Context Considering the accumulation of recent studies investigating the health effects of walnut consumption, both including and beyond cardiovascular health effects, a systematic review of this literature to investigate the strength of the evidence is warranted. Objective To investigate associations between walnut consumption and outcomes with public health relevance (specifically all-cause mortality, type 2 diabetes, CVD, metabolic syndrome, obesity, cancer, neurological and mental health, musculoskeletal, gastrointestinal, and maternal disorders) and the effect on associated disease risk markers, reported in studies published from 2017 to present. Data Sources MEDLINE, FSTA, CENTRAL, and Scopus were searched from 1 January 2017 to 5 May 2021. Data Extraction Human studies (cohort studies and RCTs) >= 3 weeks in duration comparing consumption of walnuts (whole, pieces, or 100% butter) to a control and measuring associations with relevant public health outcomes and disease risk markers were assessed. Key study characteristics were extracted independently by 2 investigators using a standardized table. The quality of the studies was assessed using the Cochrane Risk-of-Bias tool 2.0 and the Newcastle-Ottawa Scale. Data Analysis Only 1 RCT was considered to be at low risk of bias for any of its outcomes. The cohort studies were considered to be of moderate or high quality. The results were synthesized using vote counting, based on the direction of effect. Thirty-three articles, 23 describing RCTs (walnut dose similar to 10-99 g/day, 1,948 subjects) and 10 describing cohort studies (similar to 675,928 subjects), were included. Vote counting could be performed for the blood lipids, cardiovascular function, inflammation- and hemostatic-related factors, markers of glucose metabolism, and body weight and composition outcome groupings. The results are presented in effect direction plots. With respect to blood lipids, results from 8/8 RCTs favoured walnuts, in accordance with associations with a reduced risk of CVD suggested by cohort studies; results from 6/6 RCTs favoured control with respect to body weight and composition, although most of these effects were small. This was contrary to cohort study results suggesting small benefits of walnut consumption on body weight. There was no overall consistent direction of effect for cardiovascular function, markers of glucose metabolism, or inflammation- and hemostatic-related factors. Conclusions Evidence published since 2017 is consistent with previous research suggesting that walnut consumption improves lipid profiles and is associated with reduced CVD risk. Evidence is accumulating in other areas, such as cognitive health, although more research is needed to draw firm conclusions. Systematic Review Registration PROSPERO registration no. CRD4202122.
C1 [Lockyer, Stacey; de la Hunty, Anne E.; Steenson, Simon; Spiro, Ayela; Stanner, Sara A.] British Nutr Fdn, New Derwent House,69-73 Theobalds Rd, London WC1X 8TA, England.
RP Lockyer, S (corresponding author), British Nutr Fdn, New Derwent House,69-73 Theobalds Rd, London WC1X 8TA, England.
EM s.lockyer@nutrition.org.uk
OI de la Hunty, Anne/0000-0003-1403-5434; Steenson,
   Simon/0000-0003-3086-5163
FU California Walnut Commission
FX This review was funded by the California Walnut Commission. The funding
   body did not have input into the final design or conduct of the review
   or the drafting of the manuscript.
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NR 206
TC 11
Z9 11
U1 1
U2 13
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0029-6643
EI 1753-4887
J9 NUTR REV
JI Nutr. Rev.
PD DEC 6
PY 2022
VL 81
IS 1
BP 26
EP 54
DI 10.1093/nutrit/nuac040
EA AUG 2022
PG 29
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 6Y4TM
UT WOS:000834151500001
PM 35912883
OA hybrid, Green Published
DA 2025-06-11
ER

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   Ge, Hua
   Tao, Ning
   Jiang, Yu
   Zhang, YanXia
   Ning, Li
   Xiao, Jing
   Liu, Jiwen
TI Effect of Changing Work Stressors and Coping Resources on the Risk of
   Type 2 Diabetes: The OHSPIW Cohort Study
SO DIABETES CARE
LA English
DT Article
ID MONICA/KORA AUGSBURG COHORT; METABOLIC SYNDROME; MELLITUS FINDINGS;
   SOCIAL SUPPORT; BLOOD-PRESSURE; JOB STRAIN; WOMEN; MEN; METAANALYSIS;
   ASSOCIATION
AB OBJECTIVE
   Little is known about the relationship between changing psychosocial work conditions and type 2 diabetes. We determined whether changing work stressors and coping resources affect the risk of type 2 diabetes.
   RESEARCH DESIGN AND METHODS
   In this prospective cohort (2003-2014) of 3,740 workers without diabetes (OHSPIW [Occupational Health Study of PetroleumIndustryWorkers]), participants completed an evaluation of work-related stress and coping resources and type 2 diabetes diagnosis at baseline and 12 years follow-up (two waves). The changes in work stressors and coping resources were measured with the Occupation Stress Inventory-Revised and the Instrument for Stress-Related Job Analysis (Version 6.0). Type 2 diabetes was diagnosed on the basis of an oral glucose tolerance test supplemented by physician report.
   RESULTS
   Increased task stressors (relative risk [RR] 1.57 [95% CI 1.03-2.63]) and decreased coping resources (RR 1.68 [95% CI 1.02-2.83]) were associated with risk of type 2 diabetes. The main risk factors were increased role overload, increased role insufficiency, increased physical environment stressors, decreased self-care, and decreased rational coping. Increased coping resources also had a buffering effect on increased task stressors and type 2 diabetes.
   CONCLUSIONS
   Changes in work stressors and coping resources have an influence on the risk for type 2 diabetes, highlighting the importance of preventive measures against adverse psychosocial work conditions and reduced coping resources for diabetes prevention in the workplace.
C1 [Lian, Yulong; Sun, Qing; Xiao, Jing] Nantong Univ, Coll Publ Hlth, Div Occupat & Environm Hlth, Nantong, Jiangsu, Peoples R China.
   [Lian, Yulong; Guan, Suzhen; Ge, Hua; Tao, Ning; Jiang, Yu; Zhang, YanXia; Ning, Li; Liu, Jiwen] Xinjiang Med Univ, Coll Publ Hlth, Div Occupat & Environm Hlth, Urumqi, Xinjiang, Peoples R China.
C3 Nantong University; Xinjiang Medical University
RP Lian, YL (corresponding author), Nantong Univ, Coll Publ Hlth, Div Occupat & Environm Hlth, Nantong, Jiangsu, Peoples R China.; Lian, YL (corresponding author), Xinjiang Med Univ, Coll Publ Hlth, Div Occupat & Environm Hlth, Urumqi, Xinjiang, Peoples R China.
EM lianyulong444@163.com
RI ning, li/KJM-0865-2024; guan, suzhen/GWD-0465-2022
FU National Natural Science Foundation of China [81260424, 81460489,
   81260425]; Natural Science Foundation of Jiangsu Province, China
   [BK20171256]; Science and Technology Program of Nantong, China
   [12015111]
FX This work was supported by the National Natural Science Foundation of
   China (grant numbers 81260424, 81460489, and 81260425); Natural Science
   Foundation of Jiangsu Province, China (grant number BK20171256); and
   Science and Technology Program of Nantong, China (grant number
   12015111).
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NR 40
TC 11
Z9 15
U1 0
U2 27
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0149-5992
EI 1935-5548
J9 DIABETES CARE
JI Diabetes Care
PD MAR
PY 2018
VL 41
IS 3
BP 453
EP 460
DI 10.2337/dc17-0749
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism
GA GD4EI
UT WOS:000430455900023
PM 29255061
DA 2025-06-11
ER

PT J
AU Chou, IP
   Chiu, YP
   Ding, ST
   Liu, BH
   Lin, YY
   Chen, CY
AF Chou, I-Pin
   Chiu, Yao-Pang
   Ding, Shih-Torng
   Liu, Bing-Hsien
   Lin, Yuan Yu
   Chen, Ching-Yi
TI Adiponectin receptor 1 overexpression reduces lipid accumulation and
   hypertrophy in the heart of diet-induced obese mice - possible
   involvement of oxidative stress and autophagy
SO ENDOCRINE RESEARCH
LA English
DT Article
DE Adiponectin receptor 1; autophagy; diet-induced obesity; hypertrophic
   heart; lipid accumulation; oxidative stress
ID METABOLIC SYNDROME; INSULIN-RESISTANCE; MESSENGER-RNA; EXPRESSION;
   PROTECTS; GLUCOSE; MODEL
AB Background: Studies show that adiponectin and its receptors (AdipoR1 and 2) play important roles in regulating glucose and lipid metabolism in mice. Obesity, type II diabetes and cardiovascular disease are highly correlated with downregulated adiponectin signaling; however, research has not clarified the functions of AdipoR1 in vivo. Methods: In this study, mice were induced to overexpress the AdipoR1 transgene so that its functions could be studied in relation to hypertrophic cardiomyopathy. Wild-type and AdipoR1-transgenic male mice were fed ad libitum with a standard chow diet or else a high-fat/sucrose diet (HFSD) for 24 weeks, beginning at 6-7 weeks of age. Results: After receiving the 24-week HFSD, AdipoR1-transgenic mice did not become obese, nor did they develop heart hypertrophy. The AdipoR1 transgene decreased the elevating cardiac troponin I expression caused by the HFSD. While the HFSD induced mRNA expression of CD36 and CPTI, AdipoR1 reversed it. Suppression of cardiac SOD mRNA expression by the HFSD was improved by the AdipoR1 transgene. The HFSD caused a higher autophagic gene expression of Beclin 1 and Lamp 2 A in the heart, whereas the AdipoR1 transgene ameliorated them. Conclusions: The AdipoR1 transgene enabled mice to resist diet-induced obesity while decreasing lipid accumulation, oxidative stress and autophagic damage. These effects might contribute to the improvement of heart functions in diet-induced obese mice.
C1 [Chou, I-Pin; Chiu, Yao-Pang; Ding, Shih-Torng; Liu, Bing-Hsien; Lin, Yuan Yu; Chen, Ching-Yi] Natl Taiwan Univ, Dept Anim Sci & Technol, Taipei 112, Taiwan.
   [Ding, Shih-Torng] Natl Taiwan Univ, Inst Biotechnol, Taipei 112, Taiwan.
C3 National Taiwan University; National Taiwan University
RP Chen, CY (corresponding author), Natl Taiwan Univ, Dept Anim Sci & Technol, 50,Lane 155,Sec 3,Keelung Rd, Taipei 112, Taiwan.
EM ronichen@ntu.edu.tw
RI Lin, Yuan-Yu/AAD-5190-2021
OI Lin, Yuan-Yu/0000-0002-3397-3218; Chen, Ching-Yi/0000-0002-5776-084X;
   Ding, Shih-Torng/0000-0002-9866-1776
FU National Taiwan University [10R70615-3, 102R7615-3]; National Science
   Council in Taiwan [NTU-CESRP 10R70615-3, NTU-CESRP 102R7615-3]
FX All the authors state that they have no conflicts of interest. This
   study was supported in part by grants (10R70615-3 and 102R7615-3) from
   National Taiwan University and (NTU-CESRP 10R70615-3 and NTU-CESRP
   102R7615-3) from the National Science Council in Taiwan.
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NR 36
TC 27
Z9 29
U1 0
U2 6
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 0743-5800
EI 1532-4206
J9 ENDOCR RES
JI Endocr. Res.
PY 2014
VL 39
IS 4
BP 173
EP 179
DI 10.3109/07435800.2013.879165
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA AR6DM
UT WOS:000343673500007
PM 24679155
DA 2025-06-11
ER

PT J
AU Soltani, R
   Hakimi, M
   Asgary, S
   Ghanadian, SM
   Keshvari, M
   Sarrafzadegan, N
AF Soltani, Rasool
   Hakimi, Mustafa
   Asgary, Sedigheh
   Ghanadian, Syed Mustafa
   Keshvari, Mahtab
   Sarrafzadegan, Nizal
TI Evaluation of the Effects of Vaccinium arctostaphylos L.
   Fruit Extract on Serum Lipids and hs-CRP Levels and Oxidative Stress in
   Adult Patients with Hyperlipidemia: A Randomized, Double-Blind,
   Placebo-Controlled Clinical Trial
SO EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Article
ID C-REACTIVE PROTEIN; ATHEROSCLEROTIC PLAQUE-FORMATION;
   CORONARY-HEART-DISEASE; METABOLIC SYNDROME; ANTHOCYANINS; INFLAMMATION;
   ANTIOXIDANT; WOMEN; OBESE; RISK
AB Background. Dyslipidemia produces atherosclerosis, which in turn results in coronary artery disease (CAD). Atherosclerosis is being considered as an inflammatory disease. Vaccinium arctostaphylos L. is a plant with fruits rich in anthocyanins. The aim of this study was to evaluate the effects of fruit extract of this plant on serum levels of lipids, hs-CRP, and malondialdehyde (MDA) as a marker of oxidative stress, in hyperlipidemic adult patients. Methods. In this randomized, double-blind, placebo-controlled clinical trial, 50 hyperlipidemic adult patients were randomly and equally assigned to receive either medicinal (V. arctostaphylos fruit extract) or placebo capsules twice daily for 4 weeks. Each medicinal capsule contained 45 +/- 2 mg of anthocyanins. Fasting serum levels of total cholesterol, TG, LDL-C, HDL-C, hs-CRP, and MDA were obtained before and after the intervention and compared. Results. V. arctostaphylos fruit extract significantly reduced total cholesterol (P < 0.001), LDL-C (P = 0.004), TG (P < 0.001), and MDA (P = 0.013) compared to placebo but did not have any significant effect on HDL-C (P = 0.631) and hs-CRP (P = 0.190). Conclusion. Fruit extract of Vaccinium arctostaphylos has beneficial effects on serum lipid profile and oxidative stress in hyperlipidemic adult patients. Therefore, it could be considered as a supplement for treatment of dyslipidemia and prevention of atherosclerosis development.
C1 [Soltani, Rasool; Hakimi, Mustafa] Isfahan Univ Med Sci, Fac Pharm & Pharmaceut Sci, Dept Clin Pharm & Pharm Practice, Esfahan, Iran.
   [Asgary, Sedigheh; Keshvari, Mahtab; Sarrafzadegan, Nizal] Isfahan Univ Med Sci, Isfahan Cardiovasc Res Inst, Isfahan Cardiovasc Res Ctr, Esfahan, Iran.
   [Ghanadian, Syed Mustafa] Isfahan Univ Med Sci, Fac Pharm & Pharmaceut Sci, Dept Pharmacognosy, Esfahan, Iran.
C3 Isfahan University of Medical Sciences; Isfahan University of Medical
   Sciences; Isfahan University of Medical Sciences
RP Asgary, S (corresponding author), Isfahan Univ Med Sci, Isfahan Cardiovasc Res Inst, Isfahan Cardiovasc Res Ctr, Esfahan, Iran.
EM sasgary@yahoo.com
RI Soltani, Rasoul/V-8497-2017; keshvari, mahtab/ABD-4038-2020;
   Sarrafzadegan, Nizal/V-5826-2017; Ghanadian, Mustafa/H-4702-2011
OI Sarrafzadegan, Nizal/0000-0002-8352-0540; Ghanadian,
   Mustafa/0000-0001-6446-4734; Soltani, Rasoul/0000-0001-5967-3347;
   keshvari, mahtab/0000-0003-0919-4406
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NR 37
TC 56
Z9 56
U1 0
U2 23
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1741-427X
EI 1741-4288
J9 EVID-BASED COMPL ALT
JI Evid.-based Complement Altern. Med.
PY 2014
VL 2014
AR 217451
DI 10.1155/2014/217451
PG 6
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA 303LG
UT WOS:000330675100001
PM 24587807
OA Green Submitted, Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Park, HJ
   Han, JM
   Kim, HG
   Choi, MK
   Lee, JS
   Lee, HW
   Son, CG
AF Park, H-J
   Han, J-M
   Kim, H-G
   Choi, M-K
   Lee, J-S
   Lee, H-W
   Son, C-G
TI Chunggan extract (CGX), methionine-and choline-deficient (MCD)
   diet-induced hepatosteatosis and oxidative stress in C57BL/6 mice
SO HUMAN & EXPERIMENTAL TOXICOLOGY
LA English
DT Article
DE CGX; hepatosteatosis; nonalcoholic fatty liver disease; methionine and
   choline-deficient diet; oxidative stress
ID NONALCOHOLIC FATTY LIVER; METABOLIC SYNDROME; HERBAL MEDICINE;
   STEATOHEPATITIS; DISEASE; ASSAY; FEATURES; FORMULA; TISSUES; SYSTEM
AB In the present study, we aimed to evaluate the hepatoprotective and antioxidant effects of Chunggan extract (CGX) in an animal model of hepatosteatosis. The C57BL/6N mice were fed either methionine- and choline-sufficient (MCS) diet (n=10) or a methionine- and choline-deficient (MCD) diet (n=50) for 4weeks, and then they were treated orally with CGX (100 or 200mg/kg), ursodeoxycholic acid (80mg/kg, as a positive control), or distilled water (DW, MCS diet group, and MCD diet group) for the final 2weeks (once per day). The MCD diet induced severe hepatic injury with the typical features of hepatosteatosis in both serum and hepatic tissues. CGX treatment significantly attenuated these alterations in the serum levels including triglyceride (TG), aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, and total bilirubin. Moreover, CGX also efficiently prevented from the hepatic TG accumulation in the hepatic tissue, evidenced by histopathological findings, compared with the MCD diet. In addition, CGX treatment significantly ameliorated the excessive oxidative stress and antioxidant markers in the serum as well as the hepatic levels of reactive oxygen species, the levels of malondialdehyde, the protein carbonyl, and total antioxidant capacity, and the activities of superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase. In conclusion, our results indicate the experimental relevance of CGX for potential clinical application in patients with hepatosteatotic disorders and a possible mechanism related to its antioxidant properties.
C1 [Park, H-J; Han, J-M; Kim, H-G; Choi, M-K; Lee, J-S; Son, C-G] Daejeon Univ, Daejeon Oriental Hosp, Dept Liver, Taejon 301704, South Korea.
   [Park, H-J; Han, J-M; Kim, H-G; Choi, M-K; Lee, J-S; Son, C-G] Daejeon Univ, Daejeon Oriental Hosp, Immunol Res Ctr, Taejon 301704, South Korea.
   [Lee, H-W] Korea Inst Oriental Med, TKM Based Herbal Drug Res Grp, Taejon, South Korea.
C3 Daejeon University; Daejeon University; Korea Institute of Oriental
   Medicine (KIOM)
RP Son, CG (corresponding author), Daejeon Univ, Daejeon Oriental Hosp, Dept Liver, 22-5 Daeheung Dong, Taejon 301704, South Korea.
EM ckson@dju.ac.kr
RI son, chang gue/ABC-2215-2021; Lee, Hye Won/D-9081-2016
OI Lee, Hye Won/0000-0003-4248-1482; Son, Chang-Gue/0000-0003-4876-0167
FU Ministry of Health and Welfare, Republic of Korea [B120047]
FX This research was supported by the Oriental Medicine Research and
   Development Project, Ministry of Health and Welfare, Republic of Korea
   (No. B120047).
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NR 51
TC 11
Z9 12
U1 1
U2 10
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0960-3271
EI 1477-0903
J9 HUM EXP TOXICOL
JI Hum. Exp. Toxicol.
PD DEC
PY 2013
VL 32
IS 12
BP 1258
EP 1269
DI 10.1177/0960327113485253
PG 12
WC Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Toxicology
GA 258OJ
UT WOS:000327468300003
PM 23970447
OA Bronze
DA 2025-06-11
ER

PT J
AU Watany, MM
   Abd-Ellatif, RN
   Abdeldayem, ME
   El-Horany, HE
AF Watany, Mona M.
   Abd-Ellatif, Rania Nagi
   Abdeldayem, Mohamed Ezzelregal
   El-Horany, Hemat El-sayed
TI Association between genetic variations of mitochondrial isocitrate
   dehydrogenase (IDH2) and acute myocardial infarction
SO GENE
LA English
DT Article
DE IDH2 enzyme; Oxidative stress; Malondialdehyde; Oxidized low density
   lipoproteins; Mutations
ID CIRCULATING OXIDIZED LDL; LOW-DENSITY-LIPOPROTEIN; OXIDATIVE STRESS;
   METABOLIC SYNDROME; CORONARY; MARKER; RISK; DISEASE
AB Purpose: Mitochondrial isocitrate dehydrogenase (IDH2) is a major contributor to cellular redox control. The aim of this study was to preliminary link IDH2 genetic variations to redox imbalance, atherogenesis and risk of acute myocardial infarction (AMI). Methods: This case-control study included 120 AMI patients and 120 healthy controls. IDH2 genetic variations were tested using direct sequencing. IDH2 enzyme activity was measured spectrophotometrically. Malondialdehyde (MDA) and Oxidized low density lipoproteins (ox-LDL) concentrations, as biomarkers of oxidative stress, were quantitated using ELISA. Results: Four missense heterozygous mutations were detected within IDH2 gene. The variant forms of the enzyme showed a markedly reduced enzymatic activity (2.22 +/- 0.56 mU/mL in wild type compared to 0.65 +/- 0.35 mU/ mL in mutant enzyme). IDH2 enzyme activity correlated negatively with MDA and ox-LDL concentrations (r =-80.875 and-0.891 respectively). There was a strong association between IDH2 mutations and elevated MDA and ox-LDL (r(pb) = 0.764 and 0.652, both p < 0.001). After adjustment of other risk factors, IDH2 genetic variations showed to be an independent risk factor for AMI (ss=1.792, p = 0.019). Conclusions: The study proved that IDH2 genetic variations lead to impaired enzyme activity, redox imbalance, accumulation of lipid-peroxides and coronary atherogenesis. However, because such gene association has not been studied before, further studies are recommended.
C1 [Watany, Mona M.] Tanta Univ, Fac Med, Clin Pathol Dept, Tanta, Egypt.
   [Abd-Ellatif, Rania Nagi; El-Horany, Hemat El-sayed] Tanta Univ, Fac Med, Med Biochem Dept, Tanta, Egypt.
   [Abdeldayem, Mohamed Ezzelregal] Tanta Univ, Fac Med, Cardiol Dept, Tanta, Egypt.
   [El-Horany, Hemat El-sayed] Hail Univ, Coll Med, Biochem Dept, Hail, Saudi Arabia.
   [Watany, Mona M.] Tanta Univ Hosp, Clin Pathol Dept, El Geish St, Tanta 31527, Egypt.
C3 Egyptian Knowledge Bank (EKB); Tanta University; Egyptian Knowledge Bank
   (EKB); Tanta University; Egyptian Knowledge Bank (EKB); Tanta
   University; University Ha'il; Egyptian Knowledge Bank (EKB); Tanta
   University
RP Watany, MM (corresponding author), Tanta Univ Hosp, Clin Pathol Dept, El Geish St, Tanta 31527, Egypt.
EM mona.watany@med.tanta.edu.eg
RI watany, mona/AAZ-2190-2020; Elhorany, Hemat/ABF-9705-2021; Abd-ellatif,
   rania/JKJ-4807-2023
OI El-Horany, Hemat/0000-0001-7790-7530
CR Ahmadinejad F, 2017, ANTIOXIDANTS-BASEL, V6, DOI 10.3390/antiox6030051
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NR 32
TC 4
Z9 4
U1 0
U2 1
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0378-1119
EI 1879-0038
J9 GENE
JI Gene
PD JUN 30
PY 2022
VL 829
AR 146497
DI 10.1016/j.gene.2022.146497
EA APR 2022
PG 6
WC Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Genetics & Heredity
GA 1I4DH
UT WOS:000797180000004
PM 35447240
DA 2025-06-11
ER

PT S
AU Takahashi-Niki, K
   Niki, T
   Iguchi-Ariga, SMM
   Ariga, H
AF Takahashi-Niki, Kazuko
   Niki, Takeshi
   Iguchi-Ariga, Sanae M. M.
   Ariga, Hiroyoshi
BE Ariga, H
   IguchiAriga, SMM
TI Transcriptional Regulation of DJ-1
SO DJ-1/PARK7 PROTEIN: PARKINSON'S DISEASE, CANCER AND OXIDATIVE
   STRESS-INDUCED DISEASES
SE Advances in Experimental Medicine and Biology
LA English
DT Article; Book Chapter
DE DJ-1; Transcription; Oxidative stress; Parkinson's disease; Cancer
ID ANDROGEN RECEPTOR; DIRECT BINDING; OXIDATIVE STRESS; P53; PROTEIN;
   ACTIVATION; EXPRESSION; COACTIVATOR; LEGUMAIN; ALPHA
AB DJ-1 is an oncogene and also a causative gene for familial Parkinson's disease. DJ-1 has various functions, and the oxidative status of a cysteine residue at position 106 (C106) is crucial for determination of the activation level of DJ-1.
   DJ-1 binds to many proteins, including various transcription factors, and acts as a coactivator or corepressor for regulating their target genes without direct binding to DNA, thereby affecting various cell functions. DJ-1-regulating transcription factors and their modified proteins are the androgen receptor and its regulatory proteins, p53; polypyrimidine tract-binding protein-associated splicing factor (PSF); Keap1, an inhibitor for nuclear factor erythroid2-related factor 2 (Nrf2); sterol regulatory element-binding protein (SREBP); Ras-responsive element-binding protein (RREB1); signal transducer and activator of transcription 1 (STAT1); and Nurr1. Considering oxidative stress response and dopamine synthesis, the regulation of Nrf2, p53, and PSF by DJ-1 is especially important. In addition, SREBP1 and RREB1 functions that are positively regulated by DJ-1 may participate in the onset and pathogenesis of metabolic syndrome.
   DJ-1 is expressed ubiquitously with high levels in the testis and brain and moderate levels in other tissues. Furthermore, DJ-1 is translocated from the cytoplasm to nucleus during the cell cycle after mitogen stimulation, suggesting that DJ-1 has a growth-related function. In this review, we describe how DJ-1 regulates cell growth/death and dopamine synthesis by targeting various transcription factors.
C1 [Takahashi-Niki, Kazuko; Ariga, Hiroyoshi] Hokkaido Univ, Fac Pharmaceut Sci, Kita Ku, Kita 12,Nishi 6, Sapporo, Hokkaido 0600812, Japan.
   [Niki, Takeshi; Iguchi-Ariga, Sanae M. M.] Hokkaido Univ, Fac Agr, Kita Ku, Kita 9,Nishi 9, Sapporo, Hokkaido 0608589, Japan.
C3 Hokkaido University; Hokkaido University
RP Takahashi-Niki, K (corresponding author), Hokkaido Univ, Fac Pharmaceut Sci, Kita Ku, Kita 12,Nishi 6, Sapporo, Hokkaido 0600812, Japan.
EM nkazu@pharm.hokudai.ac.jp; takeshi.niki@cira.kyoto-u.ac.jp;
   myan@res.agr.hokudai.ac.jp; hiro@pharm.hokudai.ac.jp
RI Ariga, Sanae/H-9647-2013
CR Clements CM, 2006, P NATL ACAD SCI USA, V103, P15091, DOI 10.1073/pnas.0607260103
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   Zhou WB, 2005, J BIOL CHEM, V280, P43150, DOI 10.1074/jbc.M507124200
NR 25
TC 29
Z9 31
U1 0
U2 7
PU SPRINGER INTERNATIONAL PUBLISHING AG
PI CHAM
PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND
SN 0065-2598
EI 2214-8019
BN 978-981-10-6583-5; 978-981-10-6582-8
J9 ADV EXP MED BIOL
JI Adv.Exp.Med.Biol.
PY 2017
VL 1037
BP 89
EP 95
DI 10.1007/978-981-10-6583-5_7
D2 10.1007/978-981-10-6583-5
PG 7
WC Biology; Genetics & Heredity; Medicine, Research & Experimental
WE Book Citation Index – Science (BKCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics; Genetics & Heredity;
   Research & Experimental Medicine
GA BS6YQ
UT WOS:000755033000008
PM 29147905
DA 2025-06-11
ER

PT J
AU Sato, E
   Mori, T
   Satoh, M
   Fujiwara, M
   Nakamichi, Y
   Oba, I
   Ogawa, S
   Kinouchi, Y
   Sato, H
   Ito, S
   Hida, W
AF Sato, Emiko
   Mori, Takefumi
   Satoh, Michihiro
   Fujiwara, Mutsuko
   Nakamichi, Yoshimi
   Oba, Ikuko
   Ogawa, Susumu
   Kinouchi, Yoshitaka
   Sato, Hiroshi
   Ito, Sadayoshi
   Hida, Wataru
TI Urinary angiotensinogen excretion is associated with blood pressure in
   obese young adults
SO CLINICAL AND EXPERIMENTAL HYPERTENSION
LA English
DT Article
DE obese young adults; Angiotensinogen; intrarenal renin-angiotensin
   system; blood pressure; urinary biomarker
ID OXIDATIVE STRESS; METABOLIC SYNDROME; DIABETES-MELLITUS; RENAL-FAILURE;
   VISCERAL FAT; HYPERTENSION; DISEASE; INJURY; RISK
AB Intrarenal RAS has been suggested to be involved in the pathogenesis of hypertension. It was recently reported that urinary angiotensinogen excretion levels are associated with intrarenal RAS. However, few markers predicting intrarenal RAS have been investigated in obese young subjects. The present study evaluated the association between blood pressure and intrarenal RAS activity, inflammation and oxidative stress in obese young adults. Urinary angiotensinogen excretion and urinary monocyte chemotactic protein (MCP)-1, and urinary thiobarbituric acid reaction substance (TBARS) as markers of intrarenal RAS activity, inflammation, and oxidative stress, respectively, were determined from morning urine of 111 young male adults. Participants were divided into two groups based on the body mass index (BMI). Natural log-transformed urinary angiotensinogen excretion level was significantly associated with blood pressure, MCP-1 excretion, and TBARS excretion elevation in the obese group (BMI >= 25 kg/m(2)). Multivariable analyses showed that every 1 standard deviation increase in natural-log transformed urinary angiotensinogen and MCP-1 excretion, but not TBARS excretion level was associated with elevated blood pressure in the obese group. These results indicate that urinary angiotensinogen and MCP-1 excretion were associated with blood pressure elevation in this population of obese young adults. It suggested that inappropriate RAS activity and inflammation precedes hypertension in obese young subjects and urinary angiotensinogen could be a screening maker for hypertension in young obese subjects.
C1 [Sato, Emiko; Mori, Takefumi; Fujiwara, Mutsuko; Nakamichi, Yoshimi; Oba, Ikuko; Ogawa, Susumu; Sato, Hiroshi; Ito, Sadayoshi] Tohoku Univ, Grad Sch Med, Div Nephrol Endocrinol & Vasc Med, Sendai, Miyagi 9808574, Japan.
   [Sato, Emiko; Sato, Hiroshi] Tohoku Univ, Grad Sch Pharmaceut Sci, Dept Clin Pharmacol & Therapeut, Sendai, Miyagi 9808574, Japan.
   [Mori, Takefumi; Ogawa, Susumu; Kinouchi, Yoshitaka; Hida, Wataru] Tohoku Univ, Hlth Adm Ctr, Sendai, Miyagi 9808574, Japan.
   [Mori, Takefumi; Ito, Sadayoshi] Tohoku Univ, Grad Sch Med, Div Integrat Renal Replacement Therapy, Sendai, Miyagi 9808574, Japan.
   [Satoh, Michihiro] Tohoku Univ Hosp, Dept Pharm, Sendai, Miyagi, Japan.
C3 Tohoku University; Tohoku University; Tohoku University; Tohoku
   University; Tohoku University
RP Mori, T (corresponding author), Tohoku Univ, Grad Sch Med, Div Nephrol Endocrinol & Vasc Med, Aoba Ku, 1-1 Seiryo Cho, Sendai, Miyagi 9808574, Japan.
EM tmori@med.tohoku.ac.jp
RI Ito, Sadayoshi/A-3933-2015
OI Satoh, Michihiro/0000-0003-1688-1239; Ito, Sadayoshi/0000-0002-5092-3626
FU Japan Society for the Promotion of Science [2330024, 24790832];
   Grants-in-Aid for Scientific Research [24790832, 25293193] Funding
   Source: KAKEN
FX This study was supported in part by Grants for Scientific Research (Nos.
   2330024 and 24790832) from the Japan Society for the Promotion of
   Science.
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NR 26
TC 6
Z9 6
U1 0
U2 0
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1064-1963
EI 1525-6006
J9 CLIN EXP HYPERTENS
JI Clin. Exp. Hypertens.
PD FEB 17
PY 2016
VL 38
IS 2
BP 203
EP 208
DI 10.3109/10641963.2015.1081219
PG 6
WC Pharmacology & Pharmacy; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Cardiovascular System & Cardiology
GA DF3MU
UT WOS:000371249200013
PM 26825581
DA 2025-06-11
ER

PT J
AU Xin, HG
   Zhang, BB
   Wu, ZQ
   Hang, XF
   Xu, WS
   Ni, W
   Zhang, RQ
   Miao, XH
AF Xin, Hai-Guang
   Zhang, Bei-Bei
   Wu, Zhi-Qin
   Hang, Xiao-Feng
   Xu, Wen-Sheng
   Ni, Wu
   Zhang, Rui-Qi
   Miao, Xiao-Hui
TI Treatment with baicalein attenuates methionine-choline deficient
   diet-induced non-alcoholic steatohepatitis in rats
SO EUROPEAN JOURNAL OF PHARMACOLOGY
LA English
DT Article
DE Baicalein; Nonalcoholic steatohepatitis; Methionine-choline-deficient
   diet; Oxidative stress; Inflammation
ID MITOCHONDRIAL OXIDATIVE STRESS; SCUTELLARIAE RADIX; HEME OXYGENASE-1;
   LIVER-INJURY; KAPPA-B; SUPEROXIDE-DISMUTASE; FLAVONE GLUCURONIDE;
   METABOLIC SYNDROME; HEPATIC STEATOSIS; RESPIRATORY-CHAIN
AB Baicalein, a naturally occurring flavone, has been proved as a promising chemopreventive compound for many chronic human diseases. The aim of this work was to investigate whether treatment with baicalein prevented nonalcoholic steatohepatitis (NASH) induced by methionine choline-deficient (MCD) diet. Rats were divided into four experimental groups and fed for 8 weeks as follows: (1) control rats; (2) control rats treated with baicalein (intraperitoneal injection of 10 mg/kg); (3) MCD-diet-fed rats; (4) MCD-diet-fed rats treated with baicalein. Treatment with baicalein prevented MCD-diet-induced NASH, as evidenced by reduced histological scores, apoptosis, activities of ALT and AST, and hepatic fat accumulation in rats. Treatment with baicalein abated MCD-diet-induced oxidative stress through enhancing Nrf2/HO-1 pathway and activities of SOD and catalase in livers. Treatment with baicalein preserved hepatic mitochondrial function in MCD-diet fed rats. Treatment with baicalein reduced hepatic NO formation through suppressing MCD-diet-induced iNOS activation, and suppressed MCD-diet-induced inflammation through suppressing NFKI3 activation and reducing IL -6 and TNF alpha expressions in livers. Treatment of MCD-diet fed rats with baicalcin had a beneficial modulation on expression profiles of fatty acid metabolism genes in livers. The results support the investigation of baicalein as a therapeutic candidate for NASH induced by MCD diet in rats. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Xin, Hai-Guang; Zhang, Bei-Bei; Wu, Zhi-Qin; Hang, Xiao-Feng; Xu, Wen-Sheng; Ni, Wu; Zhang, Rui-Qi; Miao, Xiao-Hui] Second Mil Med Univ, Changzheng Hosp, Dept Infect Dis, Shanghai 200003, Peoples R China.
C3 Naval Medical University
RP Ni, W (corresponding author), Second Mil Med Univ, Changzheng Hosp, Dept Infect Dis, 415 Fengyang Rd, Shanghai 200003, Peoples R China.
EM miaoxh2013@hotmail.com
RI ni, wu/R-9211-2019; Zhang, Ruiqi/JRY-0376-2023
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NR 54
TC 37
Z9 43
U1 0
U2 32
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0014-2999
EI 1879-0712
J9 EUR J PHARMACOL
JI Eur. J. Pharmacol.
PD SEP 5
PY 2014
VL 738
BP 310
EP 318
DI 10.1016/j.ejphar.2014.06.006
PG 9
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA AM6TM
UT WOS:000339998000039
PM 24937020
DA 2025-06-11
ER

PT J
AU Khanal, P
   Duttaroy, AK
AF Khanal, Prabhat
   Duttaroy, Asim K. K.
TI Prospect of potential intrauterine programming impacts associated with
   COVID-19
SO FRONTIERS IN PUBLIC HEALTH
LA English
DT Review
DE COVID-19; fetal progamming; metabolic disease; nutrition; placenta
ID MATERNAL STRESS; GLUCOSE-TOLERANCE; PRENATAL EXPOSURE; LATE-GESTATION;
   DUTCH FAMINE; GROWTH; FETAL; HEALTH; RESTRICTION; RISK
AB The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) - 2019 (COVID-19) has led to a worldwide public health concern. In addition to immediate impacts on human health and well-being, COVID-19 can result in unfortunate and long-term health consequences for future generations. In particular, pregnant women and developing fetuses in low-income settings could be prone to a higher risk of undernutrition, often due to an inadequate supply of food and nutrition during a pandemic outbreak like COVID-19. Such situations can subsequently lead to an increased risk of undesirable health consequences, such as non-communicable diseases, including obesity, metabolic syndrome, hypertension, and type 2 diabetes, in individuals born to exposed mothers via fetal programming. Moreover, COVID-19 infection or related stress during pregnancy can induce long-term programming outcomes on neuroendocrinological systems in offspring after birth. However, the long-lasting consequences of the transplacental transmission of COVID-19 in offspring are currently unknown. Here we hypothesize that a COVID-19 pandemic triggers intrauterine programming outcomes in offspring due to multiple maternal factors (e.g., nutrition deficiency, stress, infection, inflammation) during pregnancy. Thus, it is crucial to establish an integrated lifetime health information system for individuals born in or around the COVID-19 pandemic to identify those at risk of adverse pre-and postnatal nutritional programming. This approach will assist in designing specific dietary or other nutritional interventions to minimize the potential undesirable outcomes in those nutritionally programmed individuals.
C1 [Khanal, Prabhat] Nord Univ, Fac Biosci & Aquaculture, Bodo, Norway.
   [Duttaroy, Asim K. K.] Univ Oslo, Inst Basic Med Sci, Fac Med, Dept Nutr, Oslo, Norway.
C3 Nord University; University of Oslo
RP Khanal, P (corresponding author), Nord Univ, Fac Biosci & Aquaculture, Bodo, Norway.
EM prabhat.khanal@nord.no
RI Khanal, Prabhat/AAZ-4444-2021; Duttaroy, Asim/J-9499-2016
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TC 1
Z9 1
U1 0
U2 7
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 2296-2565
J9 FRONT PUBLIC HEALTH
JI Front. Public Health
PD AUG 24
PY 2022
VL 10
AR 986162
DI 10.3389/fpubh.2022.986162
PG 6
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA 5A3NC
UT WOS:000862795500001
PM 36091565
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Gal-Ben-Ari, S
   Barrera, I
   Ehrlich, M
   Rosenblum, K
AF Gal-Ben-Ari, Shunit
   Barrera, Iliana
   Ehrlich, Marcelo
   Rosenblum, Kobi
TI PKR: A Kinase to Remember
SO FRONTIERS IN MOLECULAR NEUROSCIENCE
LA English
DT Review
DE PKR; protein synthesis; learning and memory; signal transduction;
   metabolic stress; aging; cancer; Alzheimer's disease
ID DOUBLE-STRANDED-RNA; DEPENDENT PROTEIN-KINASE; NF-KAPPA-B;
   TUMOR-SUPPRESSOR FUNCTION; SMALL-MOLECULE INHIBITORS; EIF2-ALPHA
   PHOSPHORYLATION; SIGNALING PATHWAY; NONCODING RNA; ALZHEIMERS-DISEASE;
   OXIDATIVE STRESS
AB Aging is a major risk factor for many diseases including metabolic syndrome, cancer, inflammation, and neurodegeneration. Identifying mechanistic common denominators underlying the impact of aging is essential for our fundamental understanding of age-related diseases and the possibility to propose new ways to fight them. One can define aging biochemically as prolonged metabolic stress, the innate cellular and molecular programs responding to it, and the new stable or unstable state of equilibrium between the two. A candidate to play a role in the process is protein kinase R (PKR), first identified as a cellular protector against viral infection and today known as a major regulator of central cellular processes including mRNA translation, transcriptional control, regulation of apoptosis, and cell proliferation. Prolonged imbalance in PKR activation is both affected by biochemical and metabolic parameters and affects them in turn to create a feedforward loop. Here, we portray the central role of PKR in transferring metabolic information and regulating cellular function with a focus on cancer, inflammation, and brain function. Later, we integrate information from open data sources and discuss current knowledge and gaps in the literature about the signaling cascades upstream and downstream of PKR in different cell types and function. Finally, we summarize current major points and biological means to manipulate PKR expression and/or activation and propose PKR as a therapeutic target to shift age/metabolic-dependent undesired steady states.
C1 [Gal-Ben-Ari, Shunit; Barrera, Iliana; Rosenblum, Kobi] Univ Haifa, Sagol Dept Neurobiol, Lab Mol & Cellular Mech Underlying Learning & Mem, Haifa, Israel.
   [Ehrlich, Marcelo] Tel Aviv Univ, George S Wise Fac Life Sci, Sch Mol Cell Biol & Biotechnol, Lab Intracellular Trafficking & Signaling, Tel Aviv, Israel.
   [Rosenblum, Kobi] Univ Haifa, Ctr Gene Manipulat Brain, Haifa, Israel.
C3 University of Haifa; Tel Aviv University; University of Haifa
RP Rosenblum, K (corresponding author), Univ Haifa, Sagol Dept Neurobiol, Lab Mol & Cellular Mech Underlying Learning & Mem, Haifa, Israel.; Rosenblum, K (corresponding author), Univ Haifa, Ctr Gene Manipulat Brain, Haifa, Israel.
EM kobir@psy.haifa.ac.il
RI Barrera, Iliana/AAM-1992-2021
OI Ehrlich, Marcelo/0000-0002-2352-1808
FU Canadian Institutes of Health Research (CIHR); International Development
   Research Centre (IDRC); Israel Science Foundation (ISF); Azrieli
   Foundation [ISF-IDRC 2395/2015]; ISF [946/17, 1966/18]; Israeli Ministry
   of Science, Technology, and Space [MOST 3-12080, MOST 3-14761];
   TransNeuro ERANET JPND - Israel Ministry of Health [3-14616]
FX This work was supported by a grant from the Canadian Institutes of
   Health Research (CIHR), the International Development Research Centre
   (IDRC), the Israel Science Foundation (ISF) and the Azrieli Foundation
   (ISF-IDRC 2395/2015 to KR); ISF 946/17 to KR, Israeli Ministry of
   Science, Technology, and Space (MOST 3-12080 and MOST 3-14761 to KR);
   TransNeuro ERANET JPND supported by the Israel Ministry of Health grant
   3-14616 to KR; and ISF grant 1966/18 to ME.
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NR 185
TC 193
Z9 232
U1 4
U2 24
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1662-5099
J9 FRONT MOL NEUROSCI
JI Front. Molec. Neurosci.
PD JAN 9
PY 2019
VL 11
AR 480
DI 10.3389/fnmol.2018.00480
PG 20
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA HG9ON
UT WOS:000455338300001
PM 30686999
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Prigent-Tessier, A
   Quirié, A
   Maguin-Gaté, K
   Szostak, J
   Mossiat, C
   Nappey, M
   Devaux, S
   Marie, C
   Demougeot, C
AF Prigent-Tessier, Anne
   Quirie, Aurore
   Maguin-Gate, Katy
   Szostak, Justyna
   Mossiat, Claude
   Nappey, Maude
   Devaux, Sylvie
   Marie, Christine
   Demougeot, Celine
TI Physical training and hypertension have opposite effects on endothelial
   brain-derived neurotrophic factor expression
SO CARDIOVASCULAR RESEARCH
LA English
DT Article
DE BDNF; Endothelium; Hypertension; Physical training; Shear stress
ID FACTOR BDNF; METABOLIC SYNDROME; MESSENGER-RNAS; ACUTE EXERCISE;
   MUSCLE-CELLS; NGF; ACTIVATION; RECEPTOR; TRKB; DYSFUNCTION
AB Changes in circulating brain-derived neurotrophic factor (BDNF) levels were reported in patients with or at risk for cardiovascular diseases associated with endothelial dysfunction, suggesting a link between BDNF and endothelial functionality. However, little is known on cardiovascular BDNF. Our aim was to investigate levels/localization, function, and relevance of cardiovascular BDNF.
   BDNF levels (western blotting) and localization (immunostaining) were assessed in the heart and aorta from rats with impaired (spontaneously hypertensive rats [SHR]), normal (Wistar Kyoto rats [WKY]), and improved (SHR and WKY subjected to physical training) endothelial function. BDNF levels were also measured in cultured endothelial cells (CECs) subjected to low and high shear stress. The cardiovascular effects of BDNF were investigated in isolated aortic rings and hearts. The results showed high BDNF levels in the heart and aorta, the expression being prominent in endothelial cells as compared with other cell types. Exogenous BDNF vasodilated aortic rings but changed neither coronary flow nor cardiac contractility. Hypertension was associated with decreased expression of BDNF in the endothelium, whereas physical training led to endothelial BDNF up-regulation not only in WKY but also in SHR. Exposure of CECs to high shear stress stimulated BDNF production and secretion.
   Cardiovascular BDNF is mainly localized within endothelial cells in which its expression is dependent on endothelial function. These results open new perspectives on the role of endothelial BDNF in cardiovascular health.
C1 [Prigent-Tessier, Anne; Quirie, Aurore; Mossiat, Claude; Marie, Christine] Univ Bourgogne, INSERM, Cognit Act & Plasticite Sensorimotrice U1093, Dijon, France.
   [Quirie, Aurore; Maguin-Gate, Katy; Szostak, Justyna; Nappey, Maude; Devaux, Sylvie; Demougeot, Celine] UFR Sci Med & Pharmaceut, EA Fonct & Dysfonct Epitheliales 4267, F-25030 Besancon, France.
   [Szostak, Justyna] CHU Vaudois, Dept Med Interne, Serv Med Vasc, CH-1011 Lausanne, Switzerland.
C3 Universite Bourgogne Europe; Institut National de la Sante et de la
   Recherche Medicale (Inserm); University of Lausanne; Centre Hospitalier
   Universitaire Vaudois (CHUV)
RP Demougeot, C (corresponding author), UFR Sci Med & Pharmaceut, EA Fonct & Dysfonct Epitheliales 4267, 19 Rue Ambroise Pare,Batiment S, F-25030 Besancon, France.
EM cdemouge@univ-fcomte.fr
RI QUIRIE, Aurore/AAZ-4875-2021
OI Demougeot, Celine/0000-0003-0639-9756; marie,
   christine/0000-0003-3724-0713; tessier, anne/0000-0001-6655-5074;
   QUIRIE, Aurore/0000-0002-8926-1834; DEVAUX, Sylvie/0000-0003-4206-7580
FU Institut National de la Sante et de la Recherche Medicale (INSERM);
   Region of Burgundy (France) [9201CPER0004S02192]; Pole de Recherche et
   d'Enseignement Superieur Bourgogne-Franche Comte (France) [PRES 2010 23]
FX This work was supported by a financial support from the Institut
   National de la Sante et de la Recherche Medicale (INSERM), from the
   Region of Burgundy (France), (grant number 9201CPER0004S02192) and from
   Pole de Recherche et d'Enseignement Superieur Bourgogne-Franche Comte
   (France) (grant number PRES 2010 23).
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NR 47
TC 67
Z9 70
U1 1
U2 8
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0008-6363
EI 1755-3245
J9 CARDIOVASC RES
JI Cardiovasc. Res.
PD DEC 1
PY 2013
VL 100
IS 3
BP 374
EP 382
DI 10.1093/cvr/cvt219
PG 9
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 257PU
UT WOS:000327398400006
PM 24092446
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Wilson, RB
   Liang, YC
   Kaushal, D
   Carr, A
AF Wilson, Robert Beaumont
   Liang, Yicong
   Kaushal, Devesh
   Carr, Anitra
TI Molecular Pharmacology of Vitamin C and Relevance to Health and
   Obesity-A Narrative Review
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE ascorbate; auxotrophs; GLUT; lipid peroxidation; obesity; oxidative
   stress; SVCT; vitamin C; Western diet
ID METABOLIC SYNDROME; PLASMA; SUPPLEMENTATION; RISK; NORFOLK; WOMEN;
   INFLAMMATION; METAANALYSIS; POPULATION; DISEASE
AB The role of food constituents as pharmacological agents is an important consideration in health and obesity. Vitamin C acts as a small molecule antioxidant but is also a co-factor for numerous transition metal-dependent enzymes involved in healthy weight and energy metabolism. Vitamin C cannot be manufactured by humans and is mainly obtained from the dietary intake of fresh fruit and vegetables. There is great variability between different nutritional guidelines in the recommended daily allowance of vitamin C. Vitamin C deficiency results from an inadequate intake of vitamin C-containing foods and also increased utilization by oxidative and carbonyl stress. Risk factors for vitamin C deficiency include cigarette smoking, malnutrition, obesity, type 2 diabetes mellitus, age, race, sex, social isolation, major surgery, and Western-type diets. Despite the common belief that vitamin C deficiency is rare in affluent countries, surveys of large populations and specific patient groups suggest otherwise. Patients with obesity typically consume highly processed, energy-dense foods which contain inadequate micronutrients. As obesity increases, larger amounts of oral vitamin C are required to achieve adequate plasma and tissue concentrations, as compared to persons with a healthy weight. This is important in the control of oxidative stress and the maintenance of homeostasis and organ function. In this narrative review, the dosage, absorption, distribution, excretion, and catabolism of vitamin C are reviewed, together with the latest findings on vitamin C pharmacology in patients with obesity.
C1 [Wilson, Robert Beaumont] Univ New South Wales Sydney, Sch Clin Med, Elizabeth St, Liverpool, NSW 2170, Australia.
   [Liang, Yicong] Univ New South Wales Sydney, Bankstown Hosp, Bankstown, NSW 2200, Australia.
   [Kaushal, Devesh] Western Sydney Univ, Campbelltown Hosp, Sydney, NSW 2560, Australia.
   [Carr, Anitra] Univ Otago, Dept Pathol & Biomed Sci, Nutr Med Res Grp, Christchurch 8140, New Zealand.
C3 University of New South Wales Sydney; University of New South Wales
   Sydney; NSW Health; Bankstown Lidcombe Hospital; Western Sydney
   University; NSW Health; Campbelltown Hospital; University of Otago
RP Wilson, RB (corresponding author), Univ New South Wales Sydney, Sch Clin Med, Elizabeth St, Liverpool, NSW 2170, Australia.
EM robert.wilson@unsw.edu.au; z5083614@zmail.unsw.edu.au;
   d.kaushal@westernsydney.edu.au; anitra.carr@otago.ac.nz
OI Liang, Yicong/0000-0001-7458-2371; , Anitra/0000-0002-5890-2977; Wilson,
   Robert/0000-0002-7408-4695
FU Ethicon; Fisher and Paykel
FX R.B.W. declares funding support for teaching, education and research
   from Ethicon and Fisher and Paykel. The other co-authors declare no
   conflict of interest
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NR 91
TC 2
Z9 2
U1 0
U2 4
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD JUL
PY 2024
VL 25
IS 14
AR 7523
DI 10.3390/ijms25147523
PG 15
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA ZS7L1
UT WOS:001277345100001
PM 39062764
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Münzel, T
   Gori, T
   Bruno, RM
   Taddei, S
AF Muenzel, Thomas
   Gori, Tommaso
   Bruno, Rosa Maria
   Taddei, Stefano
TI Is oxidative stress a therapeutic target in cardiovascular disease?
SO EUROPEAN HEART JOURNAL
LA English
DT Review
DE Oxidative stress; Myocardial ischaemia; Endothelial function
ID ENDOTHELIUM-DEPENDENT VASODILATION; RANDOMIZED CONTROLLED-TRIALS;
   CORONARY-HEART-DISEASE; NITRIC-OXIDE SYNTHASE; GTP-CYCLOHYDROLASE-I;
   VITAMIN-E; SUPEROXIDE-PRODUCTION; HUMAN ATHEROSCLEROSIS; ANTIOXIDANT
   VITAMINS; DIABETES-MELLITUS
AB An abnormal production of reactive oxygen species (ROS) and the subsequent decrease in vascular bioavailability of nitric oxide (NO) have long been proposed to be the common pathogenetic mechanism of the endothelial dysfunction, resulting from diverse cardiovascular risk factors such as hypercholesterolaemia, diabetes mellitus, chronic smoking, metabolic syndrome, and hypertension. Superoxide produced by the nicotinamide dinucleotide phosphate (NADPH) oxidase, mitochondrial sources, or the xanthine oxidase may react with NO, thereby resulting in excessive formation of peroxynitrite, a reactive nitrogen species that has been demonstrated to accelerate the atherosclerotic process by causing direct structural damage and by causing further ROS production. Despite this sound biological rationale and a number of pre-clinical and clinical lines of evidence, studies testing the effects of classical antioxidants such as vitamin C, vitamin E, or folic acid in combination with vitamin E have been disappointing. Rather, substances such as statins, angiotensin-converting enzyme inhibitors, or AT1-receptor blockers, which possess indirect antioxidant properties mediated by the stimulation of NO production and simultaneous inhibition of superoxide production (e.g. from the NADPH oxidase), have been shown to improve vascular function in pre-clinical and clinical studies and to reduce the incidence of cardiovascular events in patients with cardiovascular disease. Today, oxidative stress remains an attractive target for cardiovascular prevention and therapy. However, a deeper understanding of its source, and of its role in vascular pathology, is necessary before new trials are attempted.
C1 [Muenzel, Thomas; Gori, Tommaso] Johannes Gutenberg Univ Mainz, Univ Med Ctr, Med Klin Kardiol Angiol 2, D-55131 Mainz, Germany.
   [Bruno, Rosa Maria; Taddei, Stefano] Univ Pisa, Dept Internal Med, Pisa, Italy.
C3 Johannes Gutenberg University of Mainz; University of Pisa
RP Münzel, T (corresponding author), Johannes Gutenberg Univ Mainz, Univ Med Ctr, Med Klin Kardiol Angiol 2, Langenbeckstr 1, D-55131 Mainz, Germany.
EM tmuenzel@uni-mainz.de
RI Gori, Tommaso/F-1575-2012; Taddei, Stefano/AAB-2828-2019; Muenzel,
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NR 53
TC 361
Z9 389
U1 0
U2 56
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0195-668X
J9 EUR HEART J
JI Eur. Heart J.
PD NOV
PY 2010
VL 31
IS 22
BP 2741
EP 2748A
DI 10.1093/eurheartj/ehq396
PG 9
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 683FK
UT WOS:000284456900010
PM 20974801
OA Bronze
DA 2025-06-11
ER

PT J
AU Ma, N
   Zhang, YJ
   Liu, BB
   Jia, XJ
   Wang, R
   Lu, Q
AF Ma, Ning
   Zhang, Yujian
   Liu, Binbin
   Jia, Xiaojiao
   Wang, Rui
   Lu, Qiang
TI Associations of plasma 8-iso-prostaglandin F2α levels with
   fasting blood glucose (FBG) and intra-abdominal fat (IAF) area in
   various Glycometabolism populations
SO BMC ENDOCRINE DISORDERS
LA English
DT Article
DE Oxidative stress; 8 iso prostaglandin F-2 alpha; Abdominal fat area;
   Glycometabolism; Diabetes mellitus
ID OXIDATIVE STRESS; CARDIOMETABOLIC RISK; DIABETES-MELLITUS; BETA-CELL;
   PREDICTORS; ADIPOSITY; APOPTOSIS; TOXICITY; DISEASE; MARKER
AB Background: This study aimed to investigate the differences in oxidative stress (OS) levels represented by 8-isoprostaglandin F-2(alpha) (8-iso-PGF(2)(alpha)) and analyze its correlation with the intra-abdominal fat (IAF) area and the glycolipid index.
   Methods: We recruited a total of 160 eligible subjects. According to the blood glucose levels and the T2DM duration, subjects were divided into three groups: Type 2 Diabetes (T2DM) group, Prediabetic group, and Normal glucose-tolerance (NC) group, containing 66, 41, 53 patients, respectively. T2DM groups were additionally divided into a new-onset T2DM group including 29 patients and a non-new-onset T2DM group including 37 patients. General clinical data and biochemical indicators were collected. Intra-abdominal fat (IAF) was measured by MRI. 8-iso-PGF(2 alpha) was measured by ELISA.
   Results: Compared with the NC group, levels of systolic blood pressure (SBP), waist-to-hip ratio (WHR), FBG, 2 h postprandial glycemia(2hPG), 2 h insulin (2 h INS), IAF area, HOMA-IR, and 8-iso-PGF(2 alpha) increased, and high-density lipoprotein cholesterol (HDL-C) decreased in T2DM groups and Prediabetic group (P < 0.05). The 2 h INS level was the highest in the Prediabetic group; 2hPG, and IAF area were the highest in the new-onset T2DM group; WHR, FBG, HOMA-IR and 8-iso-PGF(2 alpha) were the highest in the non-new-onset T2DM group. Multiple stepwise regression analysis identified IAF area and FBG as the strongest and independent determinant of 8-iso-PGF(2 alpha) (P < 0.01).
   Conclusions: In various glycometabolism populations, 8-iso-PGF2 alpha is significantly correlated with FBG and IAF, this suggests that high blood glucose and abdominal obesity can increase the damage related to the OS in vivo.
C1 [Ma, Ning; Jia, Xiaojiao; Wang, Rui; Lu, Qiang] First Hosp Qinhuangdao, Dept Endocrinol, 258 Wenhua Rd, Qinhuangdao 066000, Hebei, Peoples R China.
   [Zhang, Yujian] First Hosp Qinhuangdao, Dept Orthoped, Qinhuangdao 066000, Hebei, Peoples R China.
   [Liu, Binbin] First Hosp Qinhuangdao, Dept Funct Examinat Dept, Qinhuangdao 066000, Hebei, Peoples R China.
RP Lu, Q (corresponding author), First Hosp Qinhuangdao, Dept Endocrinol, 258 Wenhua Rd, Qinhuangdao 066000, Hebei, Peoples R China.
EM luq_2021@126.com
OI Lu, Qiang/0009-0001-9287-8333
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NR 26
TC 4
Z9 5
U1 0
U2 3
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1472-6823
J9 BMC ENDOCR DISORD
JI BMC Endocr. Disord.
PD OCT 28
PY 2021
VL 21
IS 1
AR 215
DI 10.1186/s12902-021-00879-3
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA WO3TT
UT WOS:000712381400001
PM 34711211
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Soria, M
   Anson, M
   Escanero, JF
AF Soria, Marisol
   Anson, Miguel
   Escanero, Jesus F.
TI Correlation Analysis of Exercise-Induced Changes in Plasma Trace Element
   and Hormone Levels During Incremental Exercise in Well-Trained Athletes
SO BIOLOGICAL TRACE ELEMENT RESEARCH
LA English
DT Article
DE Plasma trace element; Exercise intensity; Hormone variations
ID CALCIUM-REGULATING HORMONES; TYPE-2 DIABETES-MELLITUS; THYROID-HORMONES;
   PARATHYROID-HORMONE; PHYSICAL-EXERCISE; OXIDATIVE STRESS; ZINC STATUS;
   SERUM ZINC; METABOLIC SYNDROME; GLYCEMIC CONTROL
AB This study analyzes the relationship between hormonal changes induced by exercise and variations in trace elements associated with oxidative stress during incremental exercise. Nineteen well-trained endurance athletes performed a cycle ergometer test: after a warm-up of 10 min at 2.0 W kg(-1), workload increased by 0.5 W kg(-1) every 10 min until exhaustion. The analysis was controlled for prior diet and activity patterns, levels of exercise training, and time of day (circadian rhythms). Whole blood lactate concentration and plasma concentrations of ions (Zn, Se, Mn, and Co), insulin, glucagon, aldosterone, thyroid stimulating hormone (TSH), calcitonin, and parathyroid hormone (PTH) were measured at rest; at the end of each stage; and 3, 5, and 7 min post-exercise. The statistical analysis involved paired non-parametric tests and correlation coefficients. No significant differences were found in Mn or Co levels as a function of exercise intensity. Zn and Se levels at the end of the exercise protocol and over the recovery time were significantly different to baseline. Further, Zn levels were significantly correlated with aldosterone, calcitonin, and PTH levels, while Se levels were associated with aldosterone, calcitonin, and TSH levels. Our results indicate several different patterns of association between acute changes in hormone concentrations and variations in trace element concentrations related to oxidative stress during submaximal exercise.
C1 [Soria, Marisol; Anson, Miguel; Escanero, Jesus F.] Univ Zaragoza, Sch Med, Dept Physiol & Pharmacol, C Domingo Miral S-N, E-50009 Zaragoza, Spain.
C3 University of Zaragoza
RP Soria, M (corresponding author), Univ Zaragoza, Sch Med, Dept Physiol & Pharmacol, C Domingo Miral S-N, E-50009 Zaragoza, Spain.
EM msoria@unizar.es; escanero@unizar.es
OI Anson-Manso, Miguel-Angel/0000-0002-1539-8424
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NR 89
TC 26
Z9 27
U1 2
U2 23
PU HUMANA PRESS INC
PI TOTOWA
PA 999 RIVERVIEW DRIVE SUITE 208, TOTOWA, NJ 07512 USA
SN 0163-4984
EI 1559-0720
J9 BIOL TRACE ELEM RES
JI Biol. Trace Elem. Res.
PD MAR
PY 2016
VL 170
IS 1
BP 55
EP 64
DI 10.1007/s12011-015-0466-5
PG 10
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA DD5CZ
UT WOS:000369941500007
PM 26271307
DA 2025-06-11
ER

PT J
AU Pizarro, M
   Solís, N
   Quintero, P
   Barrera, F
   Cabrera, D
   Rojas-de Santiago, P
   Arab, JP
   Padilla, O
   Roa, JC
   Moshage, H
   Wree, A
   Inzaugarat, E
   Feldstein, AE
   Fardella, CE
   Baudrand, R
   Riquelme, A
   Arrese, M
AF Pizarro, Margarita
   Solis, Nancy
   Quintero, Pablo
   Barrera, Francisco
   Cabrera, Daniel
   Rojas-de Santiago, Pamela
   Arab, Juan P.
   Padilla, Oslando
   Roa, Juan C.
   Moshage, Han
   Wree, Alexander
   Inzaugarat, Eugenia
   Feldstein, Ariel E.
   Fardella, Carlos E.
   Baudrand, Rene
   Riquelme, Arnoldo
   Arrese, Marco
TI Beneficial effects of mineralocorticoid receptor blockade in
   experimental non-alcoholic steatohepatitis
SO LIVER INTERNATIONAL
LA English
DT Article
DE fatty liver; fibrosis; inflammation; NASH; steatohepatitis
ID FATTY LIVER-DISEASE; ADIPOCYTE DYSFUNCTION; METABOLIC SYNDROME;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; HEPATIC-FIBROSIS; CARDIAC
   FIBROSIS; OBESE-PATIENTS; MICE; EPLERENONE
AB BackgroundTherapeutic options to treat Non-alcoholic steatohepatitis (NASH) are limited. Mineralocorticoid receptor (MR) activation could play a role in hepatic fibrogenesis and its modulation could be beneficial for NASH.
   AimTo investigate whether eplerenone, a specific MR antagonist, ameliorates liver damage in experimental NASH.
   MethodsC57bl6 mice were fed a choline-deficient and amino acid-defined (CDAA) diet for 22weeks with or without eplerenone supplementation. Serum levels of aminotransferases and aldosterone were measured and hepatic steatosis, inflammation and fibrosis scored histologically. Hepatic triglyceride content (HTC) and hepatic mRNA levels of pro-inflammatory pro-fibrotic, oxidative stress-associated genes and of MR were also assessed.
   ResultsCDAA diet effectively induced fibrotic NASH, and increased the hepatic expression of pro-inflammatory, pro-fibrotic and oxidative stress-associated genes. Hepatic MR mRNA levels significantly correlated with the expression of pro-inflammatory and pro-fibrotic genes and were significantly increased in hepatic stellate cells obtained from CDAA-fed animals. Eplerenone administration was associated to a reduction in histological steatosis and attenuation of liver fibrosis development, which was associated to a significant decrease in the expression of collagen-1, collagen type III, alpha 1 and Matrix metalloproteinase-2.
   ConclusionThe expression of MR correlates with inflammation and fibrosis development in experimental NASH. Specific MR blockade with eplerenone has hepatic anti-steatotic and anti-fibrotic effects. These data identify eplerenone as a potential novel therapy for NASH. Considering its safety and FDA-approved status, human studies are warranted.
C1 [Pizarro, Margarita; Solis, Nancy; Quintero, Pablo; Barrera, Francisco; Cabrera, Daniel; Rojas-de Santiago, Pamela; Arab, Juan P.; Riquelme, Arnoldo; Arrese, Marco] Pontificia Univ Catolica Chile, Dept Gastroenterol, Escuela Med, Santiago 8330024, Chile.
   [Cabrera, Daniel] Univ Bernardo O Higgins, Dept Ciencias Quim Biol, Santiago, Chile.
   [Padilla, Oslando] Pontificia Univ Catolica Chile, Dept Salud Publ, Escuela Med, Santiago 8330024, Chile.
   [Arab, Juan P.] Pontificia Univ Catolica Chile, Dept Patol, Escuela Med, Santiago 8330024, Chile.
   [Moshage, Han] Univ Groningen, Univ Med Ctr Groningen, Dept Gastroenterol & Hepatol, Groningen, Netherlands.
   [Wree, Alexander; Inzaugarat, Eugenia; Feldstein, Ariel E.] Univ Calif San Diego, Dept Pediat, San Diego, CA 92103 USA.
   [Fardella, Carlos E.; Baudrand, Rene] Pontificia Univ Catolica Chile, Dept Endocrinol, Escuela Med, Santiago 8330024, Chile.
C3 Pontificia Universidad Catolica de Chile; Universidad  Bernardo
   O'Higgins; Pontificia Universidad Catolica de Chile; Pontificia
   Universidad Catolica de Chile; University of Groningen; University of
   California System; University of California San Diego; Pontificia
   Universidad Catolica de Chile
RP Arrese, M (corresponding author), Pontificia Univ Catolica Chile, Dept Gastroenterol, Escuela Med, Marcoleta 367, Santiago 8330024, Chile.
EM marrese@med.puc.cl
RI Arab, Juan Pablo/J-5674-2019; ARRESE, MARCO/ABB-9061-2021; Wree,
   Alexander/HKW-8000-2023; CABRERA, DANIEL/AAR-5027-2020; Roa,
   Juan/K-4749-2014
OI Baudrand, Rene/0000-0002-8655-4957; Roa, Juan
   Carlos/0000-0001-8313-8774; R. de Santiago, Pamela/0000-0002-0360-1026;
   Riquelme, Arnoldo/0000-0002-8259-8960; Moshage, Han/0000-0002-4764-0246;
   Wree, Alexander/0000-0002-2968-1335; Barrera,
   Francisco/0000-0001-5334-1528
FU Fondo Nacional de Desarrollo Cientifico y Tecnologico from the
   Government of Chile [FONDECYT 1110455]; Comision Nacional de
   Investigacion Cientifica y Tecnologica (Basal Centre for Excellence in
   Science and Technology) from the Government of Chile [PFB 12/2007]; 
   [R01 DK082451]
FX Financial support: This study was partially funded by grants from the
   Fondo Nacional de Desarrollo Cientifico y Tecnologico (FONDECYT 1110455
   to M.A.) and the Comision Nacional de Investigacion Cientifica y
   Tecnologica (grant PFB 12/2007, Basal Centre for Excellence in Science
   and Technology, M.A.) both from the Government of Chile and R01 DK082451
   (to AEF).
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NR 41
TC 51
Z9 55
U1 0
U2 8
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1478-3223
EI 1478-3231
J9 LIVER INT
JI Liver Int.
PD SEP
PY 2015
VL 35
IS 9
BP 2129
EP 2138
DI 10.1111/liv.12794
PG 10
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA CP2KI
UT WOS:000359705500010
PM 25646700
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Poloczek, J
   Kazura, W
   Chelmecka, E
   Michalczyk, K
   Jochem, J
   Gumprecht, J
   Stygar, D
AF Poloczek, Jakub
   Kazura, Wojciech
   Chelmecka, Elzbieta
   Michalczyk, Katarzyna
   Jochem, Jerzy
   Gumprecht, Janusz
   Stygar, Dominika
TI Duodenojejunal Omega Switch Surgery Reduces Oxidative Stress Induced by
   Cafeteria Diet in Sprague-Dawley Rats
SO NUTRIENTS
LA English
DT Article
DE antioxidants; bariatric surgery; cafeteria diet; duodenojejunal omega
   switch (DJOS); high-fat diet; high-sugar diet; lipid peroxidation;
   obesity; oxidative stress
ID TOTAL ANTIOXIDANT CAPACITY; METABOLIC SYNDROME; OBESITY; INFLAMMATION;
   COPPER; WEIGHT; ASSAY
AB Over-nutrition with cafeteria diet leads to glycemic control failure and subsequent obesity. Bariatric surgery remains the ultimate treatment option, and when complemented with specific dietary protocol, it may mitigate the effects of oxidative stress induced by a cafeteria diet. The study measured antioxidant marker activity: superoxidase dismutase (SOD) and ceruloplasmin (CER), total antioxidant capacity (TAC), and lipid peroxidation marker concentrations: lipofuscin (LS) and malondialdehyde (MDA), in the plasma of 56 Sprague-Dawley rats fed with a cafeteria (HFS) or a control (CD) diet and subjected to duodenojejunal omega switch (DJOS) or control (SHAM) surgery. The diet change after the surgery (CD/HFS or HFS/CD) strongly influenced SOD activity in DJOS- and SHAM-operated rats, but SOD activity was always higher in SHAM-operated rats. Every dietary protocol used in the study increased CER activity, except for the CD/CD combination. Cafeteria diet consumed before or after either of surgeries led to decrease in TAC levels. DJOS and no change in diet reduced MDA levels. DJOS reduced LS levels, but its beneficial effect was deteriorated by selected dietary protocols. The cafeteria diet negatively affected the positive impact of DJOS surgery, but SOD, CER, MDA, and LS were significantly lower in rats that underwent DJOS, suggesting that eight weeks of dietary treatment before and after the surgery did not totally dilapidate the effects of the bariatric treatment.
C1 [Poloczek, Jakub] 3rd Specialist Hosp Rybnik, Dept Rehabil, Energetykow 46 St, PL-44200 Rybnik, Poland.
   [Poloczek, Jakub; Gumprecht, Janusz] Med Univ Silesia, Fac Med Sci Zabrze, Dept Internal Med Diabetol & Nephrol, Poniatowskiego 15 St, PL-40055 Katowice, Poland.
   [Kazura, Wojciech; Michalczyk, Katarzyna; Jochem, Jerzy; Stygar, Dominika] Med Univ Silesia, Fac Med Sci Zabrze, Dept Physiol, Jordana St 19, PL-40055 Katowice, Poland.
   [Chelmecka, Elzbieta] Med Univ Silesia, Fac Pharmaceut Sci Sosnowiec, Dept Stat, Dept Instrumental Anal, Poniatowskiego 15 St, PL-40055 Katowice, Poland.
C3 Medical University of Silesia; Medical University of Silesia; Medical
   University of Silesia
RP Stygar, D (corresponding author), Med Univ Silesia, Fac Med Sci Zabrze, Dept Physiol, Jordana St 19, PL-40055 Katowice, Poland.
EM dstygar@sum.edu.pl
RI Stygar, Dominika/ABG-6437-2021; Stygar, Dominika/T-4634-2018; Chelmecka,
   Elzbieta/O-5223-2015
OI Gumprecht, Janusz/0000-0001-7091-2118; Stygar,
   Dominika/0000-0001-8509-7507; Jochem, Jerzy/0000-0001-7403-2177;
   Michalczyk, Katarzyna/0000-0003-1809-9531; Jakub,
   Poloczek/0000-0003-1429-4815; Chelmecka, Elzbieta/0000-0002-0111-438X;
   Kazura, Wojciech/0000-0002-9397-1089
FU Medical University of Silesia in Katowice [PCN-1111/N/0/O]
FX This research was funded by Medical University of Silesia in Katowice
   (grant no. PCN-1111/N/0/O).
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NR 44
TC 3
Z9 3
U1 0
U2 2
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD OCT
PY 2022
VL 14
IS 19
AR 4097
DI 10.3390/nu14194097
PG 15
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 5G3JA
UT WOS:000866897300001
PM 36235749
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Gillessen, A
   Angelico, F
   Chen, J
   Lu, LE
   Lucena, MI
   Fu, QC
   Xie, Q
   Andrade, RJ
   Xie, W
   Xu, XY
   Yu, YY
   Mao, YM
   Nan, YM
AF Gillessen, Anton
   Angelico, Francesco
   Chen, Jun
   Lu, Lungen
   Lucena, Maria Isabel
   Fu, Qingchun
   Xie, Qing
   Andrade, Raul J.
   Xie, Wen
   Xu, Xiaoyuan
   Yu, Yanyan
   Mao, Yi-min
   Nan, Yuemin
TI Silymarin for Treating Toxic Liver Disease: International Consensus
   Recommendations
SO GASTRO HEP ADVANCES
LA English
DT Article
DE Alcoholic Fatty Liver Disease; Nonalcoholic Associ- ated Fatty Liver
   Disease; Metabolic Dysfunction-Associated Fatty Liver Disease;
   Drug-Induced Liver Injury; Silymarin
ID NONALCOHOLIC FATTY LIVER; STELLATE CELL ACTIVATION; OXIDATIVE STRESS;
   LIPID-PEROXIDATION; METABOLIC SYNDROME; CONTROLLED TRIAL; DOUBLE-BLIND;
   RAT MODEL; FIBROSIS; STEATOHEPATITIS
AB Chronic liver disease (CLD) is a leading health problem impacting the quality of life globally. China shares a major global burden of CLD-including alcoholic liver disease, nonalcoholic fatty liver disease/metabolic dysfunction- associated fatty liver disease, and drug-induced liver injury, except for chronic viral hepatitis. Several exogenous toxins or endogenous metabolic insults trigger hepatic pathology toward steatosis, inflammation, and fi brosis, which, if left untreated, may culminate in liver cirrhosis. Oxidative stress is a common pathomechanism underlying all phenotypes of toxic liver injury; thus, these may be brought under a unified entity, viz. toxic liver disease (TLD). Therefore, a common strategy to treat TLD is to use antioxidants as hepatoprotective agents. The cornerstone for treating fatty liver disease is lifestyle modification, diet, exercise, and behavioral therapy, along with the limited use of pharmacological agents. Available preclinical and clinical evidence indicates that silymarin is a hepatoprotective agent with established antioxidant, anti-inflammatory, antifibrotic effects. An international expert panel of clinicians was convened to discuss combining alcoholic liver disease, nonalcoholic fatty liver disease/metabolic dysfunction-associated fatty liver disease, drug-induced liver injury, and liver cirrhosis under the single definition of TLD, based on the shared pathologic mechanism of oxidative stress. The panel highlighted the significance of silymarin as an antioxidant treatment for TLD.
C1 [Gillessen, Anton; Xu, Xiaoyuan; Yu, Yanyan; Mao, Yi-min; Nan, Yuemin] Herz Jesu Hosp, Dept Internal Med, Munster, Germany.
   [Angelico, Francesco; Mao, Yi-min] Sapienza Univ, Dept Publ Hlth & Infect Dis, Sch Med, Rome, Italy.
   [Chen, Jun; Nan, Yuemin] Shenzhen Third Peoples Hosp, Dept Liver Dis, Dept Liver Dis 4, Shenzhen, Peoples R China.
   [Lu, Lungen] Shanghai Gen Hosp, Dept Gastroenterol, Shanghai, Peoples R China.
   [Lucena, Maria Isabel] Univ Malaga, Sch Med, Dept Pharmacol, Malaga, Spain.
   [Fu, Qingchun] Fudan Univ, Liver Dis Ctr, Shanghai Publ Hlth Clin Ctr, Shanghai 201508, Peoples R China.
   [Xie, Qing] Ruijin Hosp, Dept Infect Dis, Shanghai, Peoples R China.
   [Andrade, Raul J.] Univ Malaga, Univ Hosp, Dept Mental Hlth, Serv Gastroenterol & Clin Pharmacol,IBIMA, Malaga, Spain.
   [Xie, Wen] Capital Med Univ, Liver Dis Ctr, Beijing Ditan Hosp, Beijing, Peoples R China.
   [Xu, Xiaoyuan] Peking Univ, Hlth Sci Ctr, Ctr Infect Dis, Beijing 100191, Peoples R China.
   [Yu, Yanyan] Peking Univ First Hosp, Dept Infect Dis, Beijing, Peoples R China.
   [Mao, Yi-min] Renji Hosp, Dept Gastroenterol, Shanghai, Peoples R China.
   [Nan, Yuemin] Third Hosp Hebei Med Univ, Dept Joint Surg, Shijiazhuang, Peoples R China.
C3 Sapienza University Rome; The Third People's Hospital of Shenzhen;
   Universidad de Malaga; Fudan University; Shanghai Jiao Tong University;
   Instituto de Investigacion Biomedica de Malaga y Plataforma en
   Nanomedicina (IBIMA); Universidad de Malaga; Capital Medical University;
   Peking University; Peking University
RP Gillessen, A; Xu, XY (corresponding author), Herz Jesu Hosp, Dept Internal Med, Munster, Germany.; Xu, XY (corresponding author), Peking Univ, Hlth Sci Ctr, Ctr Infect Dis, Beijing 100191, Peoples R China.
EM anton.gillessen@rub.de; xiaoyuanxu6@163.com
RI Mao, Yimin/AAC-9226-2021
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NR 123
TC 3
Z9 3
U1 0
U2 1
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
EI 2772-5723
J9 GASTRO HEP ADV
JI Gastro Hep Adv.
PY 2022
VL 1
IS 5
BP 882
EP 893
DI 10.1016/j.gastha.2022.05.006
PG 12
WC Gastroenterology & Hepatology
WE Emerging Sources Citation Index (ESCI)
SC Gastroenterology & Hepatology
GA U7E1Z
UT WOS:001413372500030
PM 39131840
OA Green Published
DA 2025-06-11
ER

PT J
AU Lu, QB
   Du, Q
   Wang, HP
   Tang, ZH
   Wang, YB
   Sun, HJ
AF Lu, Qing-Bo
   Du, Qiong
   Wang, Hui-Ping
   Tang, Zi-Han
   Wang, Yuan-Ben
   Sun, Hai-Jian
TI Salusin-β mediates tubular cell apoptosis in acute kidney injury:
   Involvement of the PKC/ROS signaling pathway
SO REDOX BIOLOGY
LA English
DT Article
DE Apoptosis; Oxidative stress; DNA damage; Salusin; LPS; Cisplatin
ID RENAL ISCHEMIA-REPERFUSION; DNA-DAMAGE RESPONSE; PARAVENTRICULAR
   NUCLEUS; VASCULAR INFLAMMATION; OXIDANT STRESS; NADPH OXIDASE; ALPHA;
   HYPERTENSION; ACTIVATION; NEPHROTOXICITY
AB Salusin-beta is abundantly expressed in many organs and tissues including heart, blood vessels, brain and kidneys. Recent studies have identified salusin-beta as a bioactive peptide that contributes to various diseases, such as atherosclerosis, hypertension, diabetes and metabolic syndrome. However, the role of salusin-beta in the pathogenesis of acute kidney injury (AKI) is largely unclear. In the present study, we investigated the roles of salusin-beta in cisplatin or lipopolysaccharide (LPS)-induced renal injury. Herein, we found that salusin-beta expression was upregulated in both renal tubular cells and kidney tissues induced by both cisplatin and LPS. In vitro, silencing of salusin-beta diminished, whereas overexpression of salusin-beta exaggerated the increased PKC phosphorylation, oxidative stress, histone gamma H2AX expression, p53 activation and apoptosis in either cisplatin or LPS-challenged renal tubular cells. More importantly, salusin-beta overexpression-induced tubular cell apoptosis were abolished by using the PKC inhibitor Go 6976, reactive oxygen species (ROS) scavenger NAC, nicotinamide adenine dinucleotide phosphate (NADPH) oxidase inhibitor apocynin (Apo) or p53 inhibitor Pifithrin-alpha. In animals, blockade of salusin-beta alleviated PKC phosphorylation, ROS accumulation, DNA damage, and p53 activation as well as renal dysfunction in mice after administration of cisplatin or LPS. Taken together, these results suggest that overexpressed salusin-beta is deleterious in AKI by activation of the PKC/ROS signaling pathway, thereby priming renal tubular cells for apoptosis and death.
C1 [Lu, Qing-Bo] Southeast Univ, Affiliated ZhongDa Hosp, Sch Med, Dept Neurol, Nanjing 210009, Jiangsu, Peoples R China.
   [Du, Qiong; Wang, Hui-Ping; Tang, Zi-Han; Wang, Yuan-Ben; Sun, Hai-Jian] Jiangnan Univ, Wuxi Sch Med, Dept Basic Med, 1800 Lihu Ave, Wuxi 214122, Jiangsu, Peoples R China.
   [Sun, Hai-Jian] Natl Univ Singapore, Yong Loo Lin Sch Med, Singapore 117597, Singapore.
C3 Southeast University - China; Jiangnan University; National University
   of Singapore
RP Sun, HJ (corresponding author), Jiangnan Univ, Wuxi Sch Med, Dept Basic Med, 1800 Lihu Ave, Wuxi 214122, Jiangsu, Peoples R China.
EM phcsunh@nus.edu.sg
RI Sun, Haijian/JJC-4020-2023
OI Sun, Hai-Jian/0000-0002-7791-5335; Lu, Qing-Bo/0009-0003-9682-0061
FU Fund of the National Natural Science Foundation of China [81700364];
   Jiangsu Natural Science Foundation [BK20170179]; China Postdoctoral
   Science Foundation [2017M611688]; Jiangsu Postdoctoral Science
   Foundation [1701062C]
FX This work was supported by grants from the Fund of the National Natural
   Science Foundation of China (81700364), Jiangsu Natural Science
   Foundation (BK20170179), Project funded by China Postdoctoral Science
   Foundation (2017M611688) and Project funded by Jiangsu Postdoctoral
   Science Foundation (1701062C).
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NR 91
TC 50
Z9 51
U1 0
U2 24
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2213-2317
J9 REDOX BIOL
JI Redox Biol.
PD FEB
PY 2020
VL 30
AR 101411
DI 10.1016/j.redox.2019.101411
PG 17
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA KM1PL
UT WOS:000513891900023
PM 31884071
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Kim, MJ
   Park, CH
   Kim, DH
   Park, MH
   Park, KC
   Hyun, MK
   Lee, AK
   Moon, HR
   Chung, HY
AF Kim, Min Jo
   Park, Chan Hum
   Kim, Dae Hyun
   Park, Min Hi
   Park, Kyung Chul
   Hyun, Min Kyung
   Lee, A. Kyoung
   Moon, Hyung Ryong
   Chung, Hae Young
TI Hepatoprotective Effects of MHY3200 on High-Fat, Diet-Induced,
   Non-Alcoholic Fatty Liver Disease in Rats
SO MOLECULES
LA English
DT Article
DE 2-(4-(5-chlorobenzo[d]thiazol-2-yl)phenoxy)-2; 2-difluoroacetic acid
   (MHY3200); PPAR agonist; lipid accumulation; ER stress; insulin
   signaling; inflammation
ID ENDOPLASMIC-RETICULUM STRESS; NF-KAPPA-B; INSULIN-RESISTANCE; METABOLIC
   SYNDROME; PEROXISOME PROLIFERATOR; SIGNAL-TRANSDUCTION;
   LIPID-METABOLISM; PPAR; INFLAMMATION; OBESITY
AB This study investigated the effects of 2-(4-(5-chlorobenzo[d]thiazol-2-yl)phenoxy)-2,2-difluoroacetic acid (MHY3200) on high-fat diet (HFD)-induced hepatic lipid accumulation and inflammation. The measurement of peroxisome proliferator-activated receptor (PPAR) activity by using a luciferase assay indicated that MHY3200 was more potent than a known PPAR agonist, WY14643, in AC2F cells. Six-month-old male SD rats were fed chow or HFD for 1 month, and after, with or without added MHY3200 (1 or 2 mg/kg/day) for 4 weeks. The oral administration of MHY3200 caused a significant decrease in serum triglyceride (TG), glucose, alanine aminotransferase, and insulin, as well as a slight decrease in the level of free fatty acid and aspartate transaminase. No weight gain was detected when compared with HFD rats, and hepatic TG content was also attenuated by the administration of MHY3200. Furthermore, phosphorylation of the ER stress marker, inositol-requiring kinase 1 and its downstream gene, c-Jun N-terminal kinase, in addition to serine phosphorylation of insulin receptor substrate 1 were suppressed by MHY3200. Consistent with these results, MHY3200 administration reduced the levels of activation of protein-1, cyclooxygenase-2, and inducible nitric oxide synthase. Our results suggested that MHY3200 ameliorated HFD-induced hepatic lipid accumulation and inflammation, and improved insulin resistance through PPAR activation.
C1 [Kim, Min Jo; Kim, Dae Hyun; Park, Kyung Chul; Hyun, Min Kyung; Lee, A. Kyoung; Moon, Hyung Ryong; Chung, Hae Young] Pusan Natl Univ, Coll Pharm, Mol Inflammat Res Ctr Aging Intervent MRCA, Busan 609735, South Korea.
   [Park, Chan Hum] Rural Dev Adm, Natl Inst Hort & Herbal Sci, Dept Med Crop Res, Eumseong 27709, South Korea.
   [Park, Min Hi] Texas A&M Hlth Sci Ctr, Irma Lerma Rangel Coll Pharm, Dept Pharmaceut Sci, College Stn, TX 77843 USA.
C3 Pusan National University; National Institute of Horticultural & Herbal
   Science (NIHHS), Republic of Korea; Rural Development Administration
   (RDA), Republic of Korea; Texas A&M University System; Texas A&M
   University College Station; Texas A&M Health Science Center
RP Moon, HR; Chung, HY (corresponding author), Pusan Natl Univ, Coll Pharm, Mol Inflammat Res Ctr Aging Intervent MRCA, Busan 609735, South Korea.
EM kiki10304@gmail.com; ptman123@naver.com; bioimmune@hanmail.net;
   minhipark@tamhsc.edu; bb36509@naver.com; mminn94@naver.com;
   lak000@naver.com; mhr108@pusan.ac.kr; hyjung@pusan.ac.kr
RI LEE, Keon-Joo/AAO-4206-2020; Park, Min/AAL-9880-2020
OI Moon, Hyung Ryong/0000-0003-1119-7112; Park, Chan
   Hum/0000-0003-1183-7159
FU Pusan National University
FX This work was supported by a 2-Year Research Grant of Pusan National
   University.
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NR 29
TC 6
Z9 7
U1 0
U2 4
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1420-3049
J9 MOLECULES
JI Molecules
PD AUG
PY 2018
VL 23
IS 8
AR 2057
DI 10.3390/molecules23082057
PG 12
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA GU5AA
UT WOS:000445295500222
PM 30115876
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Martínez-García, C
   Izquierdo-Lahuerta, A
   Vivas, Y
   Velasco, I
   Yeo, TK
   Chen, S
   Medina-Gomez, G
AF Martinez-Garcia, Cristina
   Izquierdo-Lahuerta, Adriana
   Vivas, Yurena
   Velasco, Ismael
   Yeo, Tet-Kin
   Chen, Sheldon
   Medina-Gomez, Gema
TI Renal Lipotoxicity-Associated Inflammation and Insulin Resistance
   Affects Actin Cytoskeleton Organization in Podocytes
SO PLOS ONE
LA English
DT Article
ID NECROSIS-FACTOR-ALPHA; TGF-BETA; FILAMENT ORGANIZATION; FOOT PROCESSES;
   ER-STRESS; CELLS; PROTEIN; INJURY; SENSITIVITY; INHIBITION
AB In the last few decades a change in lifestyle has led to an alarming increase in the prevalence of obesity and obesity-associated complications. Obese patients are at increased risk of developing hypertension, heart disease, insulin resistance (IR), dyslipidemia, type 2 diabetes and renal disease. The excess calories are stored as triglycerides in adipose tissue, but also may accumulate ectopically in other organs, including the kidney, which contributes to the damage through a toxic process named lipotoxicity. Recently, the evidence suggests that renal lipid accumulation leads to glomerular damage and, more specifically, produces dysfunction in podocytes, key cells that compose and maintain the glomerular filtration barrier. Our aim was to analyze the early mechanisms underlying the development of renal disease associated with the process of lipotoxicity in podocytes. Our results show that treatment of podocytes with palmitic acid produced intracellular accumulation of lipid droplets and abnormal glucose and lipid metabolism. This was accompanied by the development of inflammation, oxidative stress and endoplasmic reticulum stress and insulin resistance. We found specific rearrangements of the actin cytoskeleton and slit diaphragm proteins (Nephrin, P-Cadherin, Vimentin) associated with this insulin resistance in palmitic-treated podocytes. We conclude that lipotoxicity accelerates glomerular disease through lipid accumulation and inflammation. Moreover, saturated fatty acids specifically promote insulin resistance by disturbing the cytoarchitecture of podocytes. These data suggest that renal lipid metabolism and cytoskeleton rearrangements may serve as a target for specific therapies aimed at slowing the progression of podocyte failure during metabolic syndrome.
C1 [Martinez-Garcia, Cristina; Izquierdo-Lahuerta, Adriana; Vivas, Yurena; Velasco, Ismael; Medina-Gomez, Gema] Univ Rey Juan Carlos, Dept Ciencias Basicas Salud, Area Bioquim & Genet Mol, Madrid, Spain.
   [Yeo, Tet-Kin; Chen, Sheldon] Northwestern Univ, Div Nephrol Hypertens, Chicago, IL 60611 USA.
C3 Universidad Rey Juan Carlos; Northwestern University
RP Medina-Gomez, G (corresponding author), Univ Rey Juan Carlos, Dept Ciencias Basicas Salud, Area Bioquim & Genet Mol, Avda Atenas S-N, Madrid, Spain.
EM gema.medina@urjc.es
RI Vivas, yurena/MCY-1498-2025; Medina-Gomez, Gema/F-5667-2016
OI Vivas-Garcia, Yurena/0000-0002-0230-4521; Medina-Gomez,
   Gema/0000-0001-8169-681X; Chen, Sheldon/0000-0002-5427-4969; Martinez
   Garcia/0009-0009-7055-482X
FU Programa de Ramon y Cajal, Ministerio de Ciencia e Innovacion
   [RYC-2008-02068]; Ministerio de economia y competitividad [BFU2012-
   33594, BFU2013-47384-R]; Comunidad de Madrid [S2010/BMD-2423]; Ayudas a
   la Movilidad, Universidad Rey Juan Carlos
FX This work was supported by RYC-2008-02068, Programa de Ramon y Cajal,
   Ministerio de Ciencia e Innovacion,
   http://www.idi.mineco.gob.es/portal/site/MICINN/, GMG; BFU2012- 33594,
   Ministerio de economia y competitividad,
   http://www.mineco.gob.es/portal/site/mineco/idi, GMG; BFU2013-47384-R,
   Ministerio de economia y competitividad,
   http://www.mineco.gob.es/portal/site/mineco/idi, GMG; S2010/BMD-2423,
   Comunidad de Madrid, http://www.madrid.org/cs/Satellite?
   pagename=ComunidadMadrid/Home, GMG; Ayudas a la Movilidad 2012,
   Universidad Rey Juan Carlos, http://www.urjc.es, CMG.
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NR 67
TC 80
Z9 86
U1 0
U2 10
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD NOV 6
PY 2015
VL 10
IS 11
AR e0142291
DI 10.1371/journal.pone.0142291
PG 23
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA CV6RT
UT WOS:000364398700107
PM 26545114
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Wahyuni, I
   Aulifa, DL
   Rosdianto, AM
   Levita, J
AF Wahyuni, Ika
   Aulifa, Diah Lia
   Rosdianto, Aziiz Mardanarian
   Levita, Jutti
TI The pharmacology activities of Angelica keiskei Koidzumi
   and its efficacy and safety in humans
SO HELIYON
LA English
DT Review
DE Antioxidants; 4-Hydroxyderricin; Japanese celery; Quality of life;
   Xanthoangelol
ID ACUTE-RENAL-FAILURE; OXIDATIVE STRESS; INDUCED NEPHROTOXICITY;
   CELL-LINE; INFLAMMATORY RESPONSES; INDUCED HEPATOTOXICITY; ETHANOL
   EXTRACT; EXPRESSION; LIVER; CHALCONES
AB Chronic exposure to elevated levels of pro -oxidant factors may cause structural failings at the mitochondrial DNA level and alteration of antioxidant enzymes (glutathione peroxidase, catalase, and superoxide dismutase). Oxidative stress is an imbalance between the capacity of endogenous non -enzymatic antioxidants (glutathione, alpha-lipoic acid, uric acid, ferritin, metallothionein, melatonin, and bilirubin) and the occurrence of pro -oxidant factors which may lead to the pathogenesis of various diseases that affects the kidneys, pancreas, central nervous system, and cardiovascular system. Therefore, the utilization of medicinal plants with antioxidant activity, e. g., Angelica keiskei Koidzumi which contains chalcones, is interesting to be explored. Chalcones exhibit direct and indirect antioxidant activity and prevent oxidative stress by decreasing ROS, RNS, and superoxide production. In this review, we discuss the pharmacology activities of A. keiskei Koidzumi and its efficacy in humans. The articles were explored on PubMed and Google Scholar databases and based on the titles and abstracts related to the topic of interest, and 55 articles were selected. Two main chalcones of this plant, 4-hydroxyderricin and xanthoangelol, have been reported for their various pharmacology activities. The efficacy of A. keiskei was confirmed in anti -obesity, hepatoprotective, anti -diabetes mellitus, and increasing plasma antioxidants in patients with metabolic syndrome. A keiskei is safe as proven by only mild or no adverse events reported, thus it is prospective to be further developed as an antioxidant nutraceutical.
C1 [Wahyuni, Ika] Univ Padjadjaran, Fac Pharm, Master Program Pharm, Sumedang 45363, West Java, Indonesia.
   [Wahyuni, Ika] Univ Nahdlatul Ulama, Fac Hlth, Mataram, West Nusa Tengg, Indonesia.
   [Aulifa, Diah Lia] Univ Padjadjaran, Fac Pharm, Dept Pharmaceut Anal & Med Chem, Sumedang 45363, Indonesia.
   [Rosdianto, Aziiz Mardanarian] Univ Padjadjaran, Fac Med, Dept Biomed Sci, Bandung, Indonesia.
   [Rosdianto, Aziiz Mardanarian] Univ Padjadjaran, Fac Med, Vet Med Study Program, Sumedang 45363, Indonesia.
   [Levita, Jutti] Univ Padjadjaran, Fac Pharm, Dept Pharmacol & Clin Pharm, Sumedang 45363, Indonesia.
C3 Universitas Padjadjaran; Universitas Padjadjaran; Universitas
   Padjadjaran; Universitas Padjadjaran; Universitas Padjadjaran
RP Aulifa, DL (corresponding author), Univ Padjadjaran, Fac Pharm, Dept Pharmaceut Anal & Med Chem, Sumedang 45363, Indonesia.
EM ikawahyuni006@gmail.com; diah.lia@unpad.ac.id;
   a.m.rosdianto@unpad.ac.id; jutti.levita@unpad.ac.id
RI Levita, Jutti/I-8060-2018; Aulifa, Diah/AAD-8353-2021
OI Aulifa, Diah Lia/0000-0001-8779-8972; Wahyuni, Ika/0009-0008-9584-1502
FU Rector of Universitas Padjadjaran via the Directorate of Research and
   Community Engagement Engagement [1549/UN6.3.1/PT.00/2023]
FX The authors thank the Rector of Universitas Padjadjaran via the
   Directorate of Research and Community Engagement for facilitating this
   study and funding the article processing charge (ALG Grant No.
   1549/UN6.3.1/PT.00/2023 to Prof. Jutti Levita)
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NR 130
TC 3
Z9 3
U1 2
U2 5
PU CELL PRESS
PI CAMBRIDGE
PA 50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA
EI 2405-8440
J9 HELIYON
JI Heliyon
PD JAN 30
PY 2024
VL 10
IS 2
AR e24119
DI 10.1016/j.heliyon.2024.e24119
EA JAN 2024
PG 12
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA IK9P4
UT WOS:001166339800001
PM 38357325
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Silva, EP
   Borges, LS
   Mendes-da-Silva, C
   Hirabara, SM
   Lambertucci, RH
AF Silva, E. P., Jr.
   Borges, L. S.
   Mendes-da-Silva, C.
   Hirabara, S. M.
   Lambertucci, R. H.
TI L-Arginine supplementation improves rats' antioxidant system and
   exercise performance
SO FREE RADICAL RESEARCH
LA English
DT Article
DE Sports; antioxidant; exercise and reactive species
ID INDUCED OXIDATIVE STRESS; SKELETAL-MUSCLE; METABOLIC SYNDROME;
   FREE-RADICALS; GLUTATHIONE; EXPRESSION; CAPACITY; DEFENSES; OXIDANT;
   BIOLOGY
AB Reactive species have great importance in sports performance, once they can directly regulate energy production, muscular contraction, inflammation, and fatigue. Therefore, the redox control is essential for athletes' performance. Studies demonstrated that l-arginine has an important role in the synthesis of urea, cell growth and production of nitric oxide, moreover, there are indications that it is also able to induce benefits to muscle antioxidant system through the upregulation of some antioxidant enzymes, and by inhibiting some pathways of reactive species production. Therefore, the aim of this study was to evaluate the effects of l-arginine supplementation on performance and oxidative stress of male rats (trained or not), submitted to a single session of high intensity exercise. Forty male Wistar rats were divided into four groups, control (C), control+l-arginine (C + A), trained (T), and trained+l-arginine (T + A). The aerobic training was conducted for 8 weeks. Data of maximum speed and time from tests were used as indicators of performance. Variables related to oxidative stress and antioxidant system were also evaluated. Aerobic training was capable to induce enhancements on animals' exercise performance and on their redox state. Additionally, supplementation improved rats' physical performance on both groups, control and trained. Different improvements between groups on the antioxidant capacity were observed. Nevertheless, considering the ergogenic effect of l-arginine and the lack of all positive adaptations promoted by the exercise training, untrained animals may be more exposed to oxidative damages after the practice of intense exercises.
C1 [Silva, E. P., Jr.; Borges, L. S.; Hirabara, S. M.] Cruzeiro do Sul Univ, Inst Phys Exercise Sci & Sports, Sao Paulo, Brazil.
   [Mendes-da-Silva, C.] Univ Fed Sao Paulo, Dept Biosci, Lab Neurosci & Nutr, Santos, Brazil.
   [Lambertucci, R. H.] Univ Fed Sao Paulo, Dept Biosci, Rua Silva Jardim 136, BR-11015020 Santos, SP, Brazil.
C3 Universidade Federal de Sao Paulo (UNIFESP); Universidade Federal de Sao
   Paulo (UNIFESP)
RP Lambertucci, RH (corresponding author), Univ Fed Sao Paulo, Dept Biosci, Rua Silva Jardim 136, BR-11015020 Santos, SP, Brazil.
EM rhlamber@yahoo.com.br
RI Cristiano Mendes-da-Silva, C./F-6656-2014; Lambertucci,
   Rafael/C-6975-2012; Junior, Edenilson/KHU-4746-2024; Hirabara, Sandro
   Massao/C-4014-2012; Borges, Leandro/B-6257-2015
OI Hirabara, Sandro Massao/0000-0002-7392-0444; Borges,
   Leandro/0000-0002-9755-2535
FU CAPES; CNPq; FAPESP
FX This work was supported by CAPES, CNPq, and FAPESP.
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NR 67
TC 16
Z9 17
U1 0
U2 15
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1071-5762
EI 1029-2470
J9 FREE RADICAL RES
JI Free Radic. Res.
PD MAR
PY 2017
VL 51
IS 3
BP 281
EP 293
DI 10.1080/10715762.2017.1301664
PG 13
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA ES7NM
UT WOS:000399736900004
PM 28277983
DA 2025-06-11
ER

PT J
AU Li, Y
   Zhao, S
   Zhang, W
   Zhao, P
   He, B
   Wu, N
   Han, P
AF Li, Yan
   Zhao, Sheng
   Zhang, Wei
   Zhao, Peng
   He, Bing
   Wu, Na
   Han, Ping
TI Epigallocatechin-3-O-gallate (EGCG) attenuates FFAs-induced peripheral
   insulin resistance through AMPK pathway and insulin signaling pathway in
   vivo
SO DIABETES RESEARCH AND CLINICAL PRACTICE
LA English
DT Article
DE Free fatty acids; Insulin resistance; Epigallocatechin-3-O-gallate;
   AMP-activated protein kinase; Insulin receptor substrate-1
ID FREE FATTY-ACIDS; HEPATIC GLUCOSE-PRODUCTION; GREEN TEA POLYPHENOL;
   SKELETAL-MUSCLE; OXIDATIVE STRESS; METABOLIC SYNDROME; ACTIVATION;
   KINASE; SENSITIVITY; ELEVATION
AB We aimed to investigate the effects and possible mechanisms of Epigallocatechin-3-O-gallate (EGCG) on free fatty acids (FFAs)-induced peripheral insulin resistance in vivo. Overnight-fasted Wistar rats were subjected to 48-h intravenous infusion of either saline or Intralipid plus heparin (IH) with or without different doses of EGCG co-injection. Hyperinsulinemic-euglycemic clamp was performed in awake rats to assess peripheral insulin sensitivity. Co-injection with EGCG significantly prevented FFAs-induced peripheral insulin resistance, decreased plasma markers of oxidative stress: malondialdehyde (MDA) and 8-isoprostaglandin, and increased antioxidant enzymes: superoxide dismutases (SOD) and Glutathione peroxidase (GPx). Furthermore, EGCG treatment reversed IH-induced: (1) decrease in Thr172 phosphorylation of AMP activated protein kinase (AMPK); (2) increase in protein kinase C theta(PKC theta) membrane translocation and Ser307 phosphorylation of insulin receptor substrate-1 (IRS-1); (3) decrease in Ser473 phosphorylation of Akt and Glucose transporter 4 (GLUT4) translocation in skeletal muscle and adipose tissue. Our data suggest that EGCG treatment ameliorated FFAs-induced peripheral insulin resistance in vivo, and this might be through decreasing oxidative stress and PKC theta membrane translocation, activating the AMPK pathway and improving insulin signaling pathway in vivo. This study suggests the therapeutic value of EGCG in protecting from insulin resistance caused by elevated FFAs. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
C1 [Li, Yan; Zhao, Sheng; He, Bing; Wu, Na; Han, Ping] China Med Univ, Shengjing Hosp, Dept Endocrinol, Shenyang 110004, Peoples R China.
   [Zhang, Wei] China Med Univ, Affiliated Hosp 4, Dept Endocrinol, Shenyang 110004, Peoples R China.
   [Zhao, Peng] China Med Univ, Hosp 1, Dept Med Record, Shenyang 110004, Peoples R China.
C3 China Medical University; China Medical University; China Medical
   University
RP Han, P (corresponding author), China Med Univ, Shengjing Hosp, Dept Endocrinol, Shenyang 110004, Peoples R China.
EM measme@126.com; Zhaosheng@126.com; happy2000-3000@163.com;
   Zopey_li@126.com; hb3h@hotmail.com; zgsysj@hotmail.com;
   hpdoctor@hotmail.com
RI Zhang, Wei/HOF-7252-2023; He, Bing/AAW-4869-2020
FU Bureau of Education of Liaoning Province, China [20060999]
FX This study was supported by Research Fund from the Bureau of Education
   of Liaoning Province, China (Grant No. 20060999). We are grateful to
   Miss Hui Gu for her outstanding assistance.
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NR 50
TC 82
Z9 92
U1 2
U2 39
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0168-8227
EI 1872-8227
J9 DIABETES RES CLIN PR
JI Diabetes Res. Clin. Pract.
PD AUG
PY 2011
VL 93
IS 2
BP 205
EP 214
DI 10.1016/j.diabres.2011.03.036
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 806QQ
UT WOS:000293825400021
PM 21514684
DA 2025-06-11
ER

PT J
AU Pausova, Z
AF Pausova, Z
TI From big fat cells to high blood pressure: a pathway to
   obesity-associated hypertension
SO CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION
LA English
DT Review
DE adipocyte size; hypertension; obesity
ID SELECTIVE LEPTIN RESISTANCE; NECROSIS-FACTOR-ALPHA; DIET-INDUCED
   OBESITY; INSULIN-RESISTANCE; METABOLIC SYNDROME; OXIDATIVE STRESS;
   GENE-EXPRESSION; ADIPOSE-TISSUE; LIPID-PEROXIDATION; ADIPOCYTE SIZE
AB Purpose of review The environment created by modern industrialized societies has caused an unprecedented rise in the prevalence of obesity and obesity-related disorders, including hypertension. Mechanisms that underlie the development of hypertension in obese individuals are not very well understood; they are thought to involve activation of the sympathetic nervous system, the renin-angiotensin-aldosterone system, and oxidative stress.
   Recent findings Recent research suggests that obesity-associated hypertension may be causally related to the accumulation of 'dysfunctional' adipose tissue characterized by the presence of 'large' lipid-laden adipocytes.
   Summary Excess energy-intake leads to an expansion of adipose tissue, a hallmark of obesity. But morphology of the expanded adipose tissue differs across individuals, including the size of adipocytes. The presence of 'large' rather than 'small' adipocytes is associated with functional and structural abnormalities of adipose tissue. These include increased production of bioactive molecules, such as leptin, angiotensinogen, pro-inflammatory cytokines, and reactive oxygen species; insufficient capacity to accommodate excess energy-intake leading to ectopic fat storage in tissues and in turn insulin resistance and hyperinsulinemia; and augmented macrophage infiltration enhancing the production of pro-inflammatory cytokines and reactive oxygen species. Such a 'dysfunctional' adipose tissue may, in turn, induce activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system and oxidative stress and, hence, promote the development of obesity-associated hypertension.
C1 Univ Nottingham, Brain & Body Ctr, Nottingham NG7 2RD, England.
   Univ Montreal, Ctr Hosp, Res Ctr, Montreal, PQ, Canada.
C3 University of Nottingham; Universite de Montreal
RP Univ Nottingham, Brain & Body Ctr, Univ Pk, Nottingham NG7 2RD, England.
EM zdenka.pausova@nottingham.ac.uk
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U2 9
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1062-4821
EI 1473-6543
J9 CURR OPIN NEPHROL HY
JI Curr. Opin. Nephrol. Hypertens.
PD MAR
PY 2006
VL 15
IS 2
BP 173
EP 178
DI 10.1097/01.mnh.0000214775.42103.a5
PG 6
WC Urology & Nephrology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology; Cardiovascular System & Cardiology
GA 027GO
UT WOS:000236403100013
PM 16481885
DA 2025-06-11
ER

PT J
AU Monserrat-Mesquida, M
   Bouzas, C
   García, S
   Quetglas-Llabrés, MM
   Mateos, D
   Ugarriza, L
   Gómez, C
   Sureda, A
   Tur, JA
AF Monserrat-Mesquida, Margalida
   Bouzas, Cristina
   Garcia, Silvia
   Quetglas-Llabres, Maria Magdalena
   Mateos, David
   Ugarriza, Lucia
   Gomez, Cristina
   Sureda, Antoni
   Tur, Josep A.
TI Carbon Dioxide (CO2) Dietary Emissions Are Related to
   Oxidative and Inflammatory Status in Adult Population
SO NUTRIENTS
LA English
DT Article
DE greenhouse gas emissions; oxidative stress; inflammation; biomarkers
ID PROINFLAMMATORY CYTOKINES; TNF-ALPHA; STRESS; OBESITY; BLOOD; RISK; FAT
AB Background: Carbon dioxide (CO2) is a primary greenhouse gas (GHG) causing global temperature to rise. Unsustainable diets induce an increment in the risk of obesity and noncommunicable diseases but also contribute to the global GSG burden. Objective: To assess whether CO2 dietary emissions influence the inflammatory and oxidative status of subjects with metabolic syndrome (MetS). Methods: As part of the PREDIMED-Plus study, 100 adults (55-75 years old) from the Balearic Islands, Spain, were recruited and classified according to their dietary CO2 emissions. Anthropometric parameters were determined, fasting blood samples were collected and plasma, neutrophils, and peripheral blood mononuclear cells (PBMCs) were obtained. Dietary inflammatory index (DII), adherence to a Mediterranean diet (ADM), fatty liver index (FLI), and estimated glomerular filtration (eGFR) were calculated. Clinical biochemical parameters, blood count, and oxidative stress and inflammatory biomarker levels were also determined. Results: DII was higher in participants with high dietary CO2 emissions. Adherence to the MedDiet was inversely associated with CO2 emissions. Malondialdehyde (MDA) levels were higher in urine and plasma samples from subjects with high dietary CO2 emissions. Reactive oxygen species (ROS) production by PBMCs was greater in participants with high CO2 emissions. Interleukin-15, resistin, and leptin plasma levels were increased in participants with high dietary CO2 emissions. Conclusion: Dietary CO2 emissions influence oxidative status and inflammation in relation to the increased prooxidative and proinflammatory status in PBMCs and plasma. These biomarkers were useful for monitoring diet sustainability and health.
C1 [Monserrat-Mesquida, Margalida; Bouzas, Cristina; Garcia, Silvia; Quetglas-Llabres, Maria Magdalena; Mateos, David; Ugarriza, Lucia; Gomez, Cristina; Sureda, Antoni; Tur, Josep A.] Univ Balearic Isl IUNICS, Res Grp Community Nutr & Oxidat Stress, Palma De Mallorca 07122, Spain.
   [Monserrat-Mesquida, Margalida; Bouzas, Cristina; Garcia, Silvia; Quetglas-Llabres, Maria Magdalena; Mateos, David; Ugarriza, Lucia; Sureda, Antoni; Tur, Josep A.] Inst Salud Carlos III, CIBEROBN Physiopathol Obes & Nutr, Madrid 28029, Spain.
   [Monserrat-Mesquida, Margalida; Bouzas, Cristina; Garcia, Silvia; Quetglas-Llabres, Maria Magdalena; Mateos, David; Ugarriza, Lucia; Gomez, Cristina; Sureda, Antoni; Tur, Josep A.] Hlth Res Inst Balearic Isl IdISBa, Palma De Mallorca 07120, Spain.
   [Ugarriza, Lucia] IBSalut, CS Camp Redo, Palma De Mallorca 07010, Spain.
   [Gomez, Cristina] Univ Hosp Son Espases, Clin Anal Serv, Palma De Mallorca 07198, Spain.
C3 CIBER - Centro de Investigacion Biomedica en Red; CIBEROBN; Instituto de
   Salud Carlos III; Institut Investigacio Sanitaria Illes Balears
   (IdISBa); Hospital Universitari Son Espases
RP Tur, JA (corresponding author), Univ Balearic Isl IUNICS, Res Grp Community Nutr & Oxidat Stress, Palma De Mallorca 07122, Spain.; Tur, JA (corresponding author), Inst Salud Carlos III, CIBEROBN Physiopathol Obes & Nutr, Madrid 28029, Spain.; Tur, JA (corresponding author), Hlth Res Inst Balearic Isl IdISBa, Palma De Mallorca 07120, Spain.
EM margalida.monserrat@uib.es; pep.tur@uib.es
RI Sureda, Antoni/N-9588-2019; Bouzas, Cristina/AAE-2069-2019; Mateos,
   David/N-7366-2018; Tur, Josep/AAE-5748-2020; Mesquida,
   Margalida/AAB-4773-2019; Quetglas Llabrés, Maria/AAA-4412-2019; Tur,
   Josep/F-5576-2014
OI Quetglas Llabres, Maria Magdalena/0000-0003-4155-7780; Bouzas Velasco,
   Cristina/0000-0002-1407-8461; Garcia, Silvia/0000-0003-3534-1588;
   Monserrat Mesquida, Margalida/0000-0002-8856-135X; ,
   Antoni/0000-0001-8656-6838; Tur, Josep/0000-0002-6940-0761; GOMEZ COBO,
   CRISTINA/0000-0002-9776-4730
FU Fundaci La Marat TV3; CIBEROBN is an initiative of Instituto de Salud
   Carlos III, Spain
FX The authors especially thank the participants for their enthusiastic
   collaboration and the personnel for their outstanding support and
   exceptional efforts. CIBEROBN is an initiative of Instituto de Salud
   Carlos III, Spain.
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NR 57
TC 1
Z9 1
U1 0
U2 6
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD DEC
PY 2023
VL 15
IS 24
AR 5050
DI 10.3390/nu15245050
PG 14
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA DK6N2
UT WOS:001131974800001
PM 38140309
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Roughead, EE
   Pratt, NL
   Ellett, LMK
   Ramsay, EN
   MClinEpi
   Barratt, JD
   Morris, P
   Killer, G
AF Roughead, Elizabeth E.
   Pratt, Nicole L.
   Ellett, Lisa M. Kalisch
   Ramsay, Emmae N.
   MClinEpi
   Barratt, John D.
   Morris, Philip
   Killer, Graeme
TI Posttraumatic Stress Disorder, Antipsychotic Use and Risk of Dementia in
   Veterans
SO JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
LA English
DT Article
DE posttraumatic stress disorder; antipsychotic; dementia
ID ALZHEIMERS-DISEASE; METABOLIC SYNDROME; OLDER VETERANS; METAANALYSIS;
   SCHIZOPHRENIA; CHOICE; COHORT; WAR
AB OBJECTIVES: To examine the risk of dementia associated with posttraumatic stress disorder (PTSD) and the contribution of antipsychotic use to this risk.
   DESIGN: Retrospective cohort study
   SETTING: Australia. Administrative claims data from the Australian Government Department of Veterans' Affairs were used.
   PARTICIPANTS: Male Vietnam veterans aged 55 to 65 at baseline (2001-02) with no preexisting dementia diagnosis (N = 15,612).
   MEASUREMENTS: The association between PTSD and dementia was assessed over 12 years of follow-up. Dementia was identified as a hospital diagnosis, dementia record in service disability data, or dispensing of medicines for dementia. Cox-proportional hazards models were used, with age as the time-scale. Results were stratified according to baseline antipsychotic use.
   RESULTS: No greater risk of dementia was observed with PTSD. In veterans who received antipsychotics, dementia risk was significantly higher than in those who did not (hazard ratio (HR) = 2.1, 95% confidence interval (CI) = 1.4-3.3). Dementia risk was significantly greater in veterans hospitalized for PTSD who received antipsychotics (HR = 2.2, 95% CI = 1.1-4.6) and veterans without PTSD who received antipsychotics (HR = 4.3, 95% CI = 2.1-8.6) than in those without PTSD with no antipsychotic use.
   CONCLUSION: Antipsychotic use may be a contributor to dementia risk. These findings should be interpreted with caution because the study design was observational. Further research using prospective study designs in settings where diagnostic data, cognitive function, and disease severity are available are required.
C1 [Roughead, Elizabeth E.; Pratt, Nicole L.; Ellett, Lisa M. Kalisch; Ramsay, Emmae N.; MClinEpi; Barratt, John D.] Univ South Australia, Sansom Inst, Sch Pharm & Med Sci, Qual Use Med & Pharm Res Ctr, Adelaide, SA, Australia.
   [Morris, Philip] Australian & New Zealand Mental Hlth Assoc, Gold Coast, Australia.
   [Morris, Philip] Bond Univ, Gold Coast, Australia.
   [Killer, Graeme] Dept Vet Affairs, Canberra, ACT, Australia.
C3 University of South Australia; Bond University; Department of Veterans'
   Affairs Australia
RP Ellett, LMK (corresponding author), Univ South Australia, Qual Use Med & Pharm Res Ctr, GPO Box 2471, Adelaide, SA 5001, Australia.; Ellett, LMK (corresponding author), Univ South Australia, Sansom Inst, Sch Pharm & Med Sci, GPO Box 2471, Adelaide, SA 5001, Australia.
EM lisa.kalisch@unisa.edu.au
RI Ramsay, Emmae/F-4494-2013; Ellett, Lisa/A-3043-2011; Barratt,
   John/A-1211-2011; Roughead, Libby/G-4431-2010; Pratt, Nicole/A-1348-2011
OI Roughead, Libby/0000-0002-6811-8991; Kalisch Ellett,
   Lisa/0000-0001-5063-6128; Pratt, Nicole/0000-0001-8730-8910
FU Australian Government Department of Veterans' Affairs (DVA)
FX The research was funded by the Australian Government Department of
   Veterans' Affairs (DVA) as part of the delivery of the Veterans'
   Medicines Advice and Therapeutics Education Services project.
CR [Anonymous], 2013, AUSTR GUID TREATM AC
   Australian Government Department of Health and Ageing, 2008, SCHED PHARM BEN
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NR 21
TC 19
Z9 21
U1 0
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0002-8614
EI 1532-5415
J9 J AM GERIATR SOC
JI J. Am. Geriatr. Soc.
PD JUL
PY 2017
VL 65
IS 7
BP 1521
EP 1526
DI 10.1111/jgs.14837
PG 6
WC Geriatrics & Gerontology; Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA FB0YM
UT WOS:000405870900023
PM 28306156
DA 2025-06-11
ER

PT J
AU Bournival, J
   Francoeur, MA
   Renaud, J
   Martinoli, MG
AF Bournival, Julie
   Francoeur, Marc-Andre
   Renaud, Justine
   Martinoli, Maria-Grazia
TI Quercetin and Sesamin Protect Neuronal PC12 Cells from
   High-Glucose-Induced Oxidation, Nitrosative Stress, and Apoptosis
SO REJUVENATION RESEARCH
LA English
DT Article
ID NITRIC-OXIDE SYNTHASE; DIABETIC-NEUROPATHY; PARKINSONS-DISEASE;
   MITOCHONDRIAL DYSFUNCTION; METABOLIC SYNDROME; ENDOTHELIAL-CELLS;
   GENE-EXPRESSION; KAPPA-B; DEATH; ACTIVATION
AB Complications of diabetes are now well-known to affect sensory, motor, and autonomic nerves. Diabetes is also thought to be involved in neurodegenerative processes characteristic of several neurodegenerative diseases. Indeed, it has been acknowledged recently that hyperglycemia-induced oxidative stress contributes to numerous cellular reactions typical of central nervous system deterioration. The goal of the present study was to evaluate the effects of the polyphenol quercetin and the lignan sesamin on high-glucose (HG)-induced oxidative damage in an in vitro model of dopaminergic neurons, neuronal PC12 cells. When incubated with HG (13.5 mg/mL), neuronal PC12 cells showed a significant increase of cellular death. Our results revealed that quercetin and sesamin defend neuronal PC12 cells from HG-induced cellular demise. An elevated level of reactive oxygen and nitrogen species is a consequence of improved oxidative stress after HG administration, and we demonstrated that this production diminishes with quercetin and sesamin treatment. We also found that quercetin and sesamin elicited an increment of superoxide dismutase activity. DNA fragmentation, Bax/Bcl-2 ratio, nuclear translocation of apoptosis-inducing factor, as well as poly(adenosine diphosphate [ADP]-ribose) polymerase cleavage were significantly reduced by quercetin and sesamin administration, affirming their antiapoptotic features. Also, HG treatment impacted caspase-3 cleavage, supporting caspase-3-dependent pathways as mechanisms of apoptotic death. Our results indicate a powerful role for these natural dietary compounds and emphasize preventive or complementary nutritional strategies for diabetes control.
C1 [Bournival, Julie; Francoeur, Marc-Andre; Renaud, Justine; Martinoli, Maria-Grazia] Univ Quebec Trois Rivieres, Dept Biochem, Trois Rivieres, PQ G9A 5H7, Canada.
   [Martinoli, Maria-Grazia] Univ Laval, Ctr Rech, Neurosci Res Unit, Ste Foy, PQ, Canada.
C3 University of Quebec; University of Quebec Trois Rivieres; Laval
   University
RP Martinoli, MG (corresponding author), Univ Quebec Trois Rivieres, Dept Biochem, Trois Rivieres, PQ G9A 5H7, Canada.
EM maria-grazia.martinoli@uqtr.ca
OI Martinoli, Maria-Grazia/0000-0003-2551-1950; Renaud,
   Justine/0000-0002-9213-7981
FU Natural Sciences and Engineering Research Council (Canada)
FX This work was funded by a Natural Sciences and Engineering Research
   Council (Canada) grant to MGM. We thank F. Longpre for her technical
   assistance and O. Da Silva for editing the manuscript.
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U2 17
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1549-1684
EI 1557-8577
J9 REJUV RES
JI Rejuv. Res.
PD JUN
PY 2012
VL 15
IS 3
BP 322
EP 333
DI 10.1089/rej.2011.1242
PG 12
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA 970AY
UT WOS:000306101700010
PM 22524206
DA 2025-06-11
ER

PT J
AU Crane, TE
   Kubota, C
   West, JL
   Krogge, MA
   Wertheim, BC
   Thomson, CA
AF Crane, Tracy E.
   Kubota, Chieri
   West, Julie L.
   Krogge, Mark A.
   Wertheim, Betsy C.
   Thomson, Cynthia A.
TI Increasing the Vegetable Intake Dose Is Associated with a Rise in Plasma
   Carotenoids without Modifying Oxidative Stress or Inflammation in
   Overweight or Obese Postmenopausal Women
SO JOURNAL OF NUTRITION
LA English
DT Article
ID C-REACTIVE PROTEIN; DIETARY PATTERNS; ANTIOXIDANT CAPACITY; METABOLIC
   SYNDROME; OXIDIZED LDL; MIXED FRUIT; DNA-DAMAGE; MARKERS; HEALTHY;
   BIOMARKERS
AB The optimal amount of vegetable consumption required to reduce chronic disease risk is widely debated. Intervention trials evaluating biological activity of vegetables at various doses are limited. We conducted a 3-dose, crossover feeding trial to test the hypothesis that vegetable intake is associated in a dose-dependent manner with increased plasma carotenoids and subsequently reduced oxidative stress and inflammation in 49 overweight, postmenopausal women. Participants were assigned in random order to 2 (130 g), 5 1287 g), and 10 (614 g) daily servings of fresh, greenhouse-grown vegetables for 3-wk intervals with a 4-wk washout period between treatments. Plasma total carotenoids significantly increased from 1.63 to 2.07 mu mol/L with a dose of 2 vegetable servings, from 1.49 to 2.84 mu mol/L with a dose of 5 vegetable servings, and from 1.40 to 4.42 mu mol/L with a dose of 10 vegetable servings (pre-post paired t tests, all P < 0.001). The change during each feeding period increased with each dose level (P < 0.001). Urine concentrations of 8-isoprostane F2 alpha, hexanoyl lysine, and serum high sensitivity C-reactive protein were not affected by any administered vegetable dose. In this variable-dose vegetable study, a dose-response for plasma carotenoids was demonstrated without significant change in oxidative stress and inflammation in overweight, postmenopausal women. J. Nutr. 141: 1827 1833, 2011.
C1 [Crane, Tracy E.; West, Julie L.; Krogge, Mark A.; Thomson, Cynthia A.] Univ Arizona, Dept Nutr Sci, Tucson, AZ 85721 USA.
   [Kubota, Chieri] Univ Arizona, Sch Plant Sci, Tucson, AZ USA.
   [Wertheim, Betsy C.; Thomson, Cynthia A.] Univ Arizona, Arizona Canc Ctr, Tucson, AZ USA.
C3 University of Arizona; University of Arizona; University of Arizona;
   Arizona Center Cancer Care
RP Thomson, CA (corresponding author), Univ Arizona, Dept Nutr Sci, Tucson, AZ 85721 USA.
EM cthomson@email.arizona.edu
OI Crane, Tracy/0000-0002-4288-134X
FU USDA [2008-35200-18723]; NCI Cancer Center [NIH-CCSG-CA 023074]
FX Supported by the USDA (grant no. 2008-35200-18723) as well as by a NCI
   Cancer Center Support grant (NIH-CCSG-CA 023074). Tomato crop and
   participant reimbursements provided in-kind by Euro Fresh Farms, Inc.;
   the One-A-Day Essential was a multivitamin provided by Bayer Healthcare.
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NR 60
TC 14
Z9 14
U1 0
U2 9
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0022-3166
EI 1541-6100
J9 J NUTR
JI J. Nutr.
PD OCT
PY 2011
VL 141
IS 10
BP 1827
EP 1833
DI 10.3945/jn.111.139659
PG 7
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 824HM
UT WOS:000295193000010
PM 21865569
OA Green Published, Bronze, Green Accepted
DA 2025-06-11
ER

PT J
AU Zhang, HA
   Zhou, WQ
   Wang, X
   Men, H
   Wang, JQ
   Xu, JX
   Zhou, SS
   Liu, Q
   Cai, L
AF Zhang, Haina
   Zhou, Wenqian
   Wang, Xiang
   Men, Hongbo
   Wang, Jiqun
   Xu, Jianxiang
   Zhou, Shanshan
   Liu, Quan
   Cai, Lu
TI Exacerbation by knocking-out metallothionein gene of obesity-induced
   cardiac remodeling is associated with the activation of CARD9 signaling
SO INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
LA English
DT Article
DE Obesity cardiomyopathy; Cardiac remodeling; Metallothionein; CARD9;
   Inflammation
ID OXIDATIVE STRESS; SERUM ZINC; CARDIOMYOPATHY; PREVENTION; SULFORAPHANE;
   COPPER; IRON; PATHOPHYSIOLOGY; INFLAMMATION; HYPERTROPHY
AB Obesity increases the risk of metabolic syndrome including insulin resistance, dyslipidemia, and cardiovascular disease. We demonstrated insulin resistance, cardiac hypertrophy, and cardiac inflammation in an obese mouse model induced by a high-fat diet (HFD). Caspase recruitment domain-containing protein 9 (CARD9) and B-cell lymphoma/leukemia 10 (BCL10) were upregulated, and p38 MAPK was activated in these mice. Zinc supplementation prevented these changes with upregulation of metallothionein (MT). Deletion of MT exacerbated palmitate-triggered expression of BCL10 and p38 MAPK activation and eliminated the protective benefits of zinc in palmitate-treated cardiomyocytes. Here we further investigated the mechanisms by which endogenous MT expression affects HFD-induced cardiac remodeling and the CARD9/BCL10/p38 MAPK pathway. Male MT knockout and 129S wild-type mice were assigned to receive either a normal diet or a HFD from 8-week-age for 18 weeks. MT knockout (KO) aggravated HFD-induced obesity and systemic metabolic disorder, reflected by increased body weight, perirenal white adipose tissue, and plasma cholesterol, and cardiac hypertrophy and fibrosis. Obese MT-KO mice had abundant cardiac macrophages, upregulated cardiac proinflammatory cytokines, chemokines, adhesion molecules, CARD9, and BCL10 and activated NF-kappa B. MT-KO exacerbated HFD-induced trace metal dyshomeostasis and oxidative stress. MT-KO combined with HFD-induced obesity synergistically promotes cardiac remodeling, possibly via trace metal dyshomeostasis-induced oxidative stress to trigger CARD9/BCL10-mediated NF-kappa B activation.
C1 [Zhang, Haina; Zhou, Wenqian; Wang, Xiang; Men, Hongbo; Wang, Jiqun; Xu, Jianxiang; Zhou, Shanshan; Liu, Quan; Cai, Lu] Univ Louisville, Pediat Res Inst, Dept Pediat, Louisville, KY 40202 USA.
   [Zhang, Haina] Second Hosp Jilin Univ, Jilin Univ, Dept Cardiol, Changchun 130041, Peoples R China.
   [Zhou, Wenqian; Wang, Xiang; Men, Hongbo; Wang, Jiqun; Zhou, Shanshan; Liu, Quan] First Hosp Jilin Univ, Jilin Univ, Dept Cardiovasc Dis, Changchun 130021, Peoples R China.
   [Cai, Lu] Univ Louisville, Dept Radiat Oncol, Louisville, KY 40202 USA.
   [Cai, Lu] Univ Louisville, Dept Pharmacol, Louisville, KY 40202 USA.
   [Cai, Lu] Univ Louisville, Dept Toxicol, Louisville, KY 40202 USA.
C3 University of Louisville; Jilin University; Jilin University; University
   of Louisville; University of Louisville; University of Louisville
RP Cai, L (corresponding author), Univ Louisville, Pediat Res Inst, Dept Pediat, Louisville, KY 40202 USA.
EM lu.cai@louisville.edu
FU China-U.S. University of Louisville Pediatric Research Training Exchange
   Program; National Institute Environmental Health Science [P30E5030283]
FX This work was supported in part by the China-U.S. University of
   Louisville Pediatric Research Training Exchange Program (to LC
   2014-2021, & pcy;& ocy; salary support) and National Institute
   Environmental Health Science (P30E5030283 to LC) . All personal expenses
   for HZ, WZ, XW, HM, and JW and partial research-related expenses when
   they worked in the Louisville during 2017-2021 were provided by the
   First Hospital of Jilin University, Changchun, China, under the
   agreement of the U.S.-China Pediatric Research Exchange Training
   Program.
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NR 53
TC 0
Z9 0
U1 1
U2 1
PU IVYSPRING INT PUBL
PI LAKE HAVEN
PA PO BOX 4546, LAKE HAVEN, NSW 2263, AUSTRALIA
SN 1449-2288
J9 INT J BIOL SCI
JI Int. J. Biol. Sci.
PY 2025
VL 21
IS 3
BP 1032
EP 1046
DI 10.7150/ijbs.105513
PG 15
WC Biochemistry & Molecular Biology; Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics
GA U7X2G
UT WOS:001413868500009
PM 39897024
OA Green Accepted, gold
DA 2025-06-11
ER

PT J
AU He, AX
   Zhang, YY
   Yang, YX
   Li, LJ
   Feng, XQ
   Wei, B
   Zhu, D
   Liu, YP
   Wu, L
   Zhang, LB
   Xu, ZC
   Sun, M
AF He, Axin
   Zhang, Yingying
   Yang, Yuxian
   Li, Lingjun
   Feng, Xueqin
   Wei, Bin
   Zhu, Di
   Liu, Yanping
   Wu, Lei
   Zhang, Lubo
   Xu, Zhice
   Sun, Miao
TI Prenatal high sucrose intake affected learning and memory of aged rat
   offspring with abnormal oxidative stress and NMDARs/Wnt signaling in the
   hippocampus
SO BRAIN RESEARCH
LA English
DT Article
DE Aged offspring; Prenatal high sucrose diets; Spatial cognition;
   Oxidative stress; NMDARs; Wnt/beta-catenin
ID LONG-TERM POTENTIATION; CENTRAL-NERVOUS-SYSTEM; COGNITIVE DECLINE;
   ALZHEIMERS-DISEASE; METABOLIC SYNDROME; NMDA RECEPTORS; SPATIAL MEMORY;
   WNT PATHWAY; ACTIVATION; DICKKOPF-1
AB Maternal over-nutrition may predispose offspring to obesity, type 2 diabetes and other adult diseases. The present study investigated long-term impact of prenatal high sucrose (HS) diets on cognitive capabilities in aged rat offspring. The fasting plasma glucose concentration did not differ between the control and HS groups. However, the fasting plasma insulin and insulin resistance index values were significantly increased in HS offspring that showed abnormal glucose tolerance test. HS offspring exhibited increased escape latency and swimming path length to the platform, and reduced time in the target quadrant and the number of crossing the platform, as compared with the control group. The expression of Grin2b/NR2B, Wnt2, Wnt3a and active form of beta-catenin protein were decreased, and Dickkopf-related protein 1 was increased in the HS group. In addition, the levels of lipid peroxidation biomarker thiobarbituricacid reactive substance, nicotinamide adenine dinucleotide phosphate oxidases 2 and superoxide dismutase I were significantly increased, and the activity of catalase was decreased in the hippocampus in the HS group. The results demonstrate that prenatal HS-induced metabolic changes cause cognitive deficits in aged rat offspring, probably due to altered N-methyl-D-aspartate receptors/Wnt signaling and oxidative stress in the hippocampus. (C) 2017 Elsevier B.V. All rights reserved.
C1 [He, Axin; Zhang, Yingying; Yang, Yuxian; Li, Lingjun; Feng, Xueqin; Wei, Bin; Zhu, Di; Liu, Yanping; Wu, Lei; Zhang, Lubo; Xu, Zhice; Sun, Miao] Soochow Univ, Hosp 1, Inst Fetol, Suzhou 215006, Peoples R China.
   [Zhang, Lubo; Xu, Zhice] Loma Linda Univ, Ctr Perinatal Biol, Loma Linda, CA 92350 USA.
C3 Soochow University - China; Loma Linda University
RP Xu, ZC; Sun, M (corresponding author), Soochow Univ, Hosp 1, Inst Fetol, Suzhou 215006, Peoples R China.
EM xuzhice@suda.edu.cn; miaosunsuda@163.com
RI He, Axin/JYQ-6393-2024; liu, 园园/HJI-4438-2023; miao, sun/E-2834-2018;
   lin, qing/JTU-4293-2023
OI He, Axin/0009-0003-6147-2757; Zhang, Lubo/0000-0002-9386-8938; Liu,
   Yanping/0009-0009-9729-2890; Zhang, Yingying/0000-0002-1759-0372
FU Ministry of Science and Technology of China [2013CB945400, 2012CB947600,
   2013BA104B05]; National Natural Science Foundation of China
   [81320108006, 81570960]; Jiangsu Province's Key Discipline/Laboratory of
   Fetal Medicine
FX This work is supported by Ministry of Science and Technology of China
   (2013CB945400), (2012CB947600) and (2013BA104B05); National Natural
   Science Foundation of China (81320108006) and (81570960); Jiangsu
   Province's Key Discipline/Laboratory of Fetal Medicine.
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NR 50
TC 26
Z9 27
U1 1
U2 13
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0006-8993
EI 1872-6240
J9 BRAIN RES
JI Brain Res.
PD AUG 15
PY 2017
VL 1669
BP 114
EP 121
DI 10.1016/j.brainres.2017.05.022
PG 8
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA FC3HM
UT WOS:000406729700013
PM 28532855
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Zanetti, M
   Cappellari, GG
   Graziani, A
   Barazzoni, R
AF Zanetti, Michela
   Cappellari, Gianluca Gortan
   Graziani, Andrea
   Barazzoni, Rocco
TI Unacylated Ghrelin Improves Vascular Dysfunction and Attenuates
   Atherosclerosis during High-Fat Diet Consumption in Rodents
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE endothelial dysfunction; obesity; ghrelin; nitric oxide; superoxide
ID DES-ACYL GHRELIN; NITROGLYCERINE-INDUCED VASODILATION; MICROVASCULAR
   ENDOTHELIAL-CELLS; OIL RED-O; OXIDATIVE STRESS; QUANTIFICATION;
   RESISTANCE; ARTERY; AORTA; COMBINATION
AB Unacylated ghrelin (UnGhr) exerts several beneficial actions on vascular function. The aim of this study was to assess the effects of UnGhr on high-fat induced endothelial dysfunction and its underlying mechanisms. Thoracic aortas from transgenic mice, which were overexpressing UnGhr and being control fed either a standard control diet (CD) or a high-fat diet (HFD) for 16 weeks, were harvested and used for the assessment of vascular reactivity, endothelial nitric oxide synthase (eNOS) expression and activity, thiobarbituric acid reactive substances (TBARS) and glutathione levels, and aortic lipid accumulation by Oil Red O staining. Relaxations due to acetylcholine and to DEA-NONOate were reduced (p < 0.05) in the HFD control aortas compared to vessels from the CD animals. Overexpression of UnGhr prevented HFD-induced vascular dysfunction, while eNOS expression and activity were similar in all vessels. HFD-induced vascular oxidative stress was demonstrated by increased (p < 0.05) aortic TBARS and glutathione in wild type (Wt) mice; however, this was not seen in UnGhr mice. Moreover, increased (p < 0.05) HFD-induced lipid accumulation in vessels from Wt mice was prevented by UnGhr overexpression. In conclusion, chronic UnGhr overexpression results in improved vascular function and reduced plaque formation through decreased vascular oxidative stress, without affecting the eNOS pathway. This research may provide new insight into the mechanisms underlying the beneficial effects of UnGhr on the vascular dysfunction associated with obesity and the metabolic syndrome.
C1 [Zanetti, Michela; Cappellari, Gianluca Gortan; Barazzoni, Rocco] Univ Trieste, Dept Med Sci, I-34127 Trieste, Italy.
   [Graziani, Andrea] Univ Piemonte Orientale Amedeo Avogadro, Dept Translat Med, Via Solaroli 17, I-28100 Novara, Italy.
   [Graziani, Andrea] Univ Vita Salute San Raffaele, Sch Med, Via Olgettina 58, I-20132 Milan, Italy.
C3 University of Trieste; University of Eastern Piedmont Amedeo Avogadro;
   Vita-Salute San Raffaele University
RP Zanetti, M (corresponding author), Univ Trieste, Dept Med Sci, I-34127 Trieste, Italy.
EM zanetti@units.it; gigici2@iol.it; andrea.graziani@med.unipmn.it;
   barazzon@units.it
RI Graziani, Andrea/AAB-6301-2022; Cappellari, Gianluca/B-7132-2013
OI Gortan Cappellari, Gianluca/0000-0002-0438-5003; ZANETTI,
   MICHELA/0000-0002-2634-6363
FU CARIPLO [2016-1042, IG-178014]
FX This study was funded by grants CARIPLO, 2016-1042 to A.G. and to R.B.
   and A.I.R.C., IG-178014 to A.G.
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NR 53
TC 19
Z9 20
U1 0
U2 2
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD FEB 1
PY 2019
VL 20
IS 3
AR 499
DI 10.3390/ijms20030499
PG 10
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA HQ4WR
UT WOS:000462412500043
PM 30682769
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Mohseni, R
   Sadeghabadi, ZA
   Goodarzi, MT
   Teimouri, M
   Nourbakhsh, M
   Azar, MR
AF Mohseni, Roohollah
   Sadeghabadi, Zahra Arab
   Goodarzi, Mohammad Taghi
   Teimouri, Maryam
   Nourbakhsh, Mitra
   Azar, Maryam Razzaghy
TI Evaluation of Mn-superoxide dismutase and catalase gene expression in
   childhood obesity: its association with insulin resistance
SO JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
LA English
DT Article
DE catalase; obesity; peripheral blood mononuclear cells (PBMCs);
   superoxide dismutase
ID BODY-MASS INDEX; OXIDATIVE STRESS; METABOLIC SYNDROME; CHILDREN;
   INFLAMMATION; DISEASE; MICE
AB Background: Obesity is associated with oxidative stress. Superoxide dismutase (SOD) is the first line of defense against reactive oxygen species (ROS), eliminating the strong superoxide radical and producing H2O2, which can then be degraded by catalase (CAT). The main objective of this study was to evaluate the gene expression antioxidant enzymes (Mn-SOD and CAT) in peripheral blood mononuclear cells (PBMCs) of obese and normal-weight children, and its association with anthropometric and biochemical parameters.
   Methods: Thirty obese and 30 control subjects between the ages of 8 and 16 years were enrolled in this study. Serum insulin levels were measured using enzyme-linked immunosorbent assay (ELISA), and insulin resistance was calculated using the homeostasis model assessment of insulin resistance (HOMA-IR). Biochemical parameters were also measured. PBMCs of the subjects were separated and Mn-SOD and CAT gene expression was measured using real-time polymerase chain reaction (PCR).
   Results: Mn-SOD and CAT gene expression was significantly lower in the obese group compared with the control group (p < 0.01). Also, a positive correlation was observed between the gene expression of Mn-SOD and CAT and body mass index (BMI), fasting blood sugar, insulin resistance, low density lipoprotein-cholesterol (LDL-C) cholesterol, triglycerides (TG) and systolic blood pressure (SBP).
   Conclusions: Induction of antioxidants, especially Mn-SOD and CAT, can lead to reduction of oxidative stress and prevent the complications of obesity in children.
C1 [Goodarzi, Mohammad Taghi] Hamadan Univ Med Sci, Res Ctr Mol Med, Hamadan, Iran.
   [Mohseni, Roohollah; Sadeghabadi, Zahra Arab] Hamadan Univ Med Sci, Dept Clin Biochem, Fac Med, Hamadan, Iran.
   [Teimouri, Maryam] Univ Tehran Med Sci, Dept Clin Biochem, Fac Med, Tehran, Iran.
   [Nourbakhsh, Mitra] Iran Univ Med Sci, Dept Clin Biochem, Fac Med, Tehran, Iran.
   [Azar, Maryam Razzaghy] Univ Tehran Med Sci, Endocrinol & Metab Mol Cellular Sci Inst, Metab Disorders Res Ctr, Tehran, Iran.
   [Azar, Maryam Razzaghy] Iran Univ Med Sci, H Aliasghar Childrens Hosp, Tehran, Iran.
C3 Hamadan University of Medical Sciences; Hamadan University of Medical
   Sciences; Tehran University of Medical Sciences; Iran University of
   Medical Sciences; Tehran University of Medical Sciences; Iran University
   of Medical Sciences
RP Goodarzi, MT (corresponding author), Hamadan Univ Med Sci, Res Ctr Mol Med, Hamadan, Iran.
EM mtgoodarzi@yahoo.com
RI Nourbakhsh, Mitra/D-5214-2018; Mohseni, Rooholla/AAX-2500-2020;
   Razzaghy-Azar, Maryam/E-4968-2011; Goodarzi, Mohammad/AAC-8798-2019;
   teimouri, maryam/AAO-9967-2021
OI Teimouri, Maryam/0000-0002-3904-3951; Goodarzi, Mohammad
   Taghi/0000-0002-5546-5812
FU Hamadan University of Medical Science, Iran
FX This work was supported by an operating grant from Hamadan University of
   Medical Science, Iran.
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NR 31
TC 27
Z9 28
U1 1
U2 7
PU WALTER DE GRUYTER GMBH
PI BERLIN
PA GENTHINER STRASSE 13, D-10785 BERLIN, GERMANY
SN 0334-018X
EI 2191-0251
J9 J PEDIATR ENDOCR MET
JI J. Pediatr. Endocrinol. Metab.
PD JUL
PY 2018
VL 31
IS 7
BP 727
EP 732
DI 10.1515/jpem-2017-0322
PG 6
WC Endocrinology & Metabolism; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Pediatrics
GA GM2ZA
UT WOS:000437963500004
PM 29953407
DA 2025-06-11
ER

PT J
AU Whaley-Connell, A
   Sowers, JR
AF Whaley-Connell, Adam
   Sowers, James R.
TI Oxidative Stress in the Cardiorenal Metabolic Syndrome
SO CURRENT HYPERTENSION REPORTS
LA English
DT Article
DE Hypertension; Cardiorenal syndrome; Oxidative stress; Aldosterone;
   Obesity; Insulin resistance; Renin-angiotensin-aldosterone system; Redox
   control
ID ANGIOTENSIN-ALDOSTERONE SYSTEM; CORONARY-HEART-DISEASE;
   INSULIN-RESISTANCE; CARDIOVASCULAR-DISEASE; RENIN INHIBITION; NAD(P)H
   OXIDASE; CLINICAL-IMPLICATIONS; INDUCED HYPERTENSION; NADPH OXIDASES;
   BLOOD-PRESSURE
AB Excess visceral adiposity contributes to inappropriate activation of the renin-angiotensin-aldosterone system despite a state of volume expansion and of salt retention that contributes to subclinical elevations of pro-oxidant mechanisms. These adverse effects are mediated by excess generation of reactive oxygen species (ROS) and diminished antioxidant defense mechanisms. Excess tissue (i.e., skeletal muscle, liver, heart) free oxygen radicals contribute to impairments in the insulin-dependent metabolic signaling pathways that regulate glucose utilization/disposal and systemic insulin sensitivity. The generation of ROS is required for normal cell signaling and physiological responses. It is a loss of redox homeostasis that results in a proinflammatory/profibrotic milieu that promotes impairments in insulin metabolic signaling, reduced endothelial-mediated vasorelaxation, and associated cardiovascular and renal structural and functional abnormalities. These maladaptive processes are increasingly recognized as important in the progression of hypertension in the cardiorenal metabolic phenotype. There is increasing evidence to support a critical role for Ang II signaling through the AT(1)R and aldosterone actions through the MR in conjunction with an altered redox-mediating impaired endothelial, cardiac and renal function in this metabolic phenotype. There are emerging clinical data that indicate that therapies that target the renin angiotensin-aldosterone system (RAAS) also attenuate oxidative stress, and improve endothelial, cardiac and renal functions, which collectively contribute to reductions in hypertension.
C1 [Whaley-Connell, Adam] Harry S Truman VA Med Ctr, Div Nephrol & Hypertens, Columbia, MO 65213 USA.
   [Whaley-Connell, Adam; Sowers, James R.] Univ Missouri, Sch Med, Columbia, MO 65213 USA.
   [Whaley-Connell, Adam; Sowers, James R.] Harry S Truman VA Med Ctr, Diabet & Cardiovasc Ctr, Columbia, MO 65213 USA.
C3 US Department of Veterans Affairs; Veterans Health Administration (VHA);
   Harry S. Truman Memorial Veterans' Hospital; University of Missouri
   System; University of Missouri Columbia; US Department of Veterans
   Affairs; Veterans Health Administration (VHA); Harry S. Truman Memorial
   Veterans' Hospital; University of Missouri System; University of
   Missouri Columbia
RP Whaley-Connell, A (corresponding author), Harry S Truman VA Med Ctr, Div Nephrol & Hypertens, CE427,DC043-0,5 Hosp Dr, Columbia, MO 65213 USA.
EM whaleyconnella@health.missouri.edu
OI Whaley-Connell, Adam/0000-0001-8955-5560
FU National Institutes of Health (NIH)
FX Dr. Sowers has received research support from National Institutes of
   Health (NIH).
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NR 49
TC 46
Z9 55
U1 1
U2 9
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1522-6417
EI 1534-3111
J9 CURR HYPERTENS REP
JI Curr. Hypertens. Rep.
PD AUG
PY 2012
VL 14
IS 4
BP 360
EP 365
DI 10.1007/s11906-012-0279-2
PG 6
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 968BY
UT WOS:000305953200012
PM 22581415
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Othman, EM
   Hintzsche, H
   Stopper, H
AF Othman, Eman Maher
   Hintzsche, Henning
   Stopper, Helga
TI Signaling steps in the induction of genomic damage by insulin in colon
   and kidney cells
SO FREE RADICAL BIOLOGY AND MEDICINE
LA English
DT Article
DE Diabetes; Insulin; Genotoxicity; Mitochondria; NADPH oxidase; Free
   radicals
ID OXIDATIVE STRESS; DNA-DAMAGE; METABOLIC SYNDROME; CANCER CELLS; IN-VIVO;
   ACTIVATION; MITOCHONDRIA; GENERATION; RECEPTOR; KINASE
AB Diabetes mellitus (DM), a disease with almost 350 million people affected worldwide, will be the seventh leading cause of death by 2030. Diabetic patients develop various types of complications, among them an increased rate of malignancies. Studies reported the strong correlation between DM and several cancer types, of which colon and kidney cancers are the most common. Hyperinsulinemia, the high insulin blood level characteristic of early diabetes type 2, was identified as a risk factor for cancer development. In previous studies, we showed that an elevated insulin level can induce oxidative stress, resulting in DNA damage in colon cells in vitro and in kidney cells in vitro and in vivo. In the present study, we elucidate the signaling pathway of insulin-mediated genotoxicity, which is effective through oxidative stress induction in colon and kidney. The signaling mechanism is starting by phosphorylation of the insulin and insulin-like growth factor-1 receptors, followed by activation of phosphatidylinositide 3-kinase (PI3K), which in turn activates AKT. Subsequently, mitochondria and nicotinamide adenine dinucleotide phosphate oxidase (NADPH) isoforms (Noxl and Nox4 in colon and kidney, respectively) are activated for reactive oxygen species (ROS) production, and the resulting excess ROS can attack the DNA, causing DNA oxidation. We conclude that hyperinsulinemia represents an important risk factor for cancer initiation or progression as well as a target for cancer prevention in diabetic patients. (C) 2013 Elsevier Inc. All rights reserved.
C1 [Othman, Eman Maher; Hintzsche, Henning; Stopper, Helga] Univ Wurzburg, Inst Pharmacol & Toxicol, D-97078 Wurzburg, Germany.
   [Othman, Eman Maher] Univ El Minia, Fac Pharm, Dept Analyt Chem, El Minia 61519, Egypt.
C3 University of Wurzburg; Egyptian Knowledge Bank (EKB); Minia University
RP Stopper, H (corresponding author), Univ Wurzburg, Inst Pharmacol & Toxicol, D-97078 Wurzburg, Germany.
EM stopper@toxi.uni-wuerzburg.de
RI Othman, Eman/LBI-5240-2024
OI Hintzsche, Henning/0000-0002-0332-2967; Othman, Eman
   M./0000-0003-4781-9745
FU DAAD STIBET Doktoranden Program; Frauenburo, University of Wurzburg,
   Wurzburg, Germany
FX We thank Christin Thiel for her expert technical assistance. E. Maher
   was supported by the DAAD STIBET Doktoranden Program and a postdoctoral
   fellowship from the Frauenburo, University of Wurzburg, Wurzburg,
   Germany.
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NR 47
TC 24
Z9 26
U1 0
U2 10
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0891-5849
EI 1873-4596
J9 FREE RADICAL BIO MED
JI Free Radic. Biol. Med.
PD MAR
PY 2014
VL 68
BP 247
EP 257
DI 10.1016/j.freeradbiomed.2013.12.010
PG 11
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA AC3OA
UT WOS:000332429900024
PM 24355212
DA 2025-06-11
ER

PT J
AU Dilixiati, D
   Waili, A
   Tuerxunmaimaiti, A
   Tao, LW
   Zebibula, A
   Rexiati, M
AF Dilixiati, Diliyaer
   Waili, Alapati
   Tuerxunmaimaiti, Aizihaier
   Tao, Liwen
   Zebibula, Abudureheman
   Rexiati, Mulati
TI Risk factors for erectile dysfunction in diabetes mellitus: a systematic
   review and meta-analysis
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Article
DE diabetes mellitus; erectile dysfunction; risk factors; meta-analysis;
   sexual dysfuction
ID JAPANESE PATIENTS; SEXUAL DYSFUNCTION; CARDIOVASCULAR RISK; CHINESE MEN;
   CARE CENTER; PREVALENCE; ASSOCIATION; TYPE-1; HEALTH; PREDICTORS
AB Background Previous studies have established that diabetes mellitus (DM) markedly raises the risk of developing erectile dysfunction (ED). Despite extensive investigations, the risk factors associated with ED in diabetic men have yet to be unequivocally determined, owing to incongruent and inconclusive results reported in various studies.Objective The objective of this systematic review and meta-analysis was to assess the risk factors for ED in men with DM.Methods A comprehensive systematic review was conducted, encompassing studies published in the PubMed, Scopus and Embase databases up to August 24th, 2023. All studies examining the risk factors of ED in patients with DM were included in the analysis. To identify significant variations among the risk factors, odds ratios (ORs) and their corresponding 95% confidence intervals (CIs) were employed. The risk of bias was evaluated using the Newcastle-Ottawa Scale(NOS) for longitudinal studies and the Agency for Healthcare Research and Quality Scale(AHRQ) for cross-sectional studies.Results A total of 58 studies, including a substantial participant pool of 66,925 individuals diagnosed with DM, both with or without ED, were included in the meta-analysis. Mean age (OR: 1.31, 95% CI=1.24-1.37), smoking status (OR: 1.32, 95% CI=1.18-1.47), HbA1C (OR: 1.44, 95% CI=1.28-1.62), duration of DM (OR: 1.39, 95% CI=1.29-1.50), diabetic neuropathy (OR: 3.47, 95% CI=2.16-5.56), diabetic retinopathy (OR: 3.01, 95% CI=2.02-4.48), diabetic foot (OR: 3.96, 95% CI=2.87-5.47), cardiovascular disease (OR: 1.92, 95% CI=1.71-2.16), hypertension (OR: 1.74, 95% CI=1.52-2.00), microvascular disease (OR: 2.14, 95% CI=1.61-2.85), vascular disease (OR: 2.75, 95% CI=2.35-3.21), nephropathy (OR: 2.67, 95% CI=2.06-3.46), depression (OR: 1.82, 95% CI=1.04-3.20), metabolic syndrome (OR: 2.22, 95% CI=1.98-2.49), and diuretic treatment (OR: 2.42, 95% CI=1.38-4.22) were associated with increased risk factors of ED in men with DM.Conclusion Our study indicates that in men with DM, several risk factors for ED have been identified, including mean age, HbA1C, duration of DM, diabetic neuropathy, diabetic retinopathy, diabetic foot, cardiovascular disease, hypertension, microvascular disease, vascular disease, nephropathy, depression, metabolic syndrome, and diuretic treatment. By clarifying the connection between these risk factors and ED, clinicians and scientific experts can intervene and address these risk factors, ultimately reducing the occurrence of ED and improving patient management.
C1 [Dilixiati, Diliyaer; Zebibula, Abudureheman; Rexiati, Mulati] Xinjiang Med Univ, Affiliated Hosp 1, Dept Urol, Urumqi, Peoples R China.
   [Waili, Alapati; Tao, Liwen] Xinjiang Med Univ, Affiliated Hosp 1, Dept Pancreat Surg, Urumqi, Peoples R China.
   [Tuerxunmaimaiti, Aizihaier] Xinjiang Med Univ, Affiliated Hosp 1, Dept Cardiac Surg, Urumqi, Peoples R China.
C3 Xinjiang Medical University; Xinjiang Medical University; Xinjiang
   Medical University
RP Zebibula, A; Rexiati, M (corresponding author), Xinjiang Med Univ, Affiliated Hosp 1, Dept Urol, Urumqi, Peoples R China.
EM 11618010@zju.edu.cn; muratrixat@126.com
RI Dilixiati, Diliyaer/LQK-2906-2024
OI Waili, Alapati/0009-0005-8469-4912
FU Xinjiang Uygur Autonomous Region Regional Collaborative Innovation
   Special Science and Technology Assistance Program FOUNDATION
   [2022E02129]; National Natural Science Foundation of China [NSFC
   82260139]
FX The author(s) declare financial support was received for the research,
   authorship, and/or publication of this article. This research was
   supported by Xinjiang Uygur Autonomous Region Regional Collaborative
   Innovation Special Science and Technology Assistance Program
   FOUNDATION(No.2022E02129); National Natural Science Foundation of China
   (NSFC 82260139).
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NR 103
TC 17
Z9 17
U1 1
U2 13
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD APR 4
PY 2024
VL 15
AR 1368079
DI 10.3389/fendo.2024.1368079
PG 20
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA OA8M9
UT WOS:001204630800001
PM 38638136
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Ferrantelli, V
   Vasto, S
   Alongi, A
   Sabatino, L
   Baldassano, D
   Caldarella, R
   Gagliano, R
   Di Rosa, L
   Consentino, BB
   Vultaggio, L
   Baldassano, S
AF Ferrantelli, Vincenzo
   Vasto, Sonya
   Alongi, Angelina
   Sabatino, Leo
   Baldassano, Davide
   Caldarella, Rosalia
   Gagliano, Rosaria
   Di Rosa, Luigi
   Consentino, Beppe Benedetto
   Vultaggio, Lorena
   Baldassano, Sara
TI Boosting plant food polyphenol concentration by saline eustress as
   supplement strategies for the prevention of metabolic syndrome: an
   example of randomized interventional trial in the adult population
SO FRONTIERS IN NUTRITION
LA English
DT Article
DE MetS; diet; body homeostasis; functional food; lettuce; phytochemicals;
   nutritional intervention
ID LIVER-DISEASE; CAFFEIC ACID; BONE; QUALITY; HEALTH; RUTIN
AB IntroductionPhenolic compounds in lettuce can increase by the application of positive stress (eustress) such as moderate saline stress. Phenolic compounds possess antioxidant capacity that is a key factor in the detoxification of excess reactive oxygen species. A double-blinded randomized interventional and placebo- controlled study design was carried out to compare the effect of daily dietary eustress lettuce ingestion in hepatic, lipid, bone, glucose, and iron metabolism.MethodsForty-two healthy volunteers, 19 female and 23 male participants, were divided into two groups. Participants were randomized into a polyphenol-enriched treatment (PET) arm or control arm. Each arm consumed 100 g/day of control or eustress (polyphenols enriched treatment = PET) lettuce for 12 days. Primary study outcomes were serological analysis for assessing hepatic, lipid, bone, iron, and glucose markers at baseline and after 12 days. Secondary outcomes assessed body composition.ResultsSalinity stress reduced plant yield but increased caffeic acid (+467%), chlorogenic acid (+320%), quercetin (+538%), and rutin (+1,095%) concentrations. The intake of PET lettuce reduced PTH, low-density lipoprotein (LDL), cholesterol, alanine transaminase (ALT), and aspartate transaminase (AST) enzyme levels and increased vitamin D and phosphate levels, while iron and glucose metabolism were unaffected.DiscussionSupplementation with eustress lettuce by increasing polyphenols concentration ameliorates hepatic, lipid, and bone homeostasis. Body composition was not affected.Clinical trial registrationhttps://classic.clinicaltrials.gov/ct2/show/NCT06002672, identifier: NCT06002672.
C1 [Ferrantelli, Vincenzo; Alongi, Angelina; Gagliano, Rosaria] Expt Zooprophylact Inst Sicily, Palermo, Italy.
   [Vasto, Sonya] Euro Mediterranean Inst Sci & Technol IEMEST, Palermo, Italy.
   [Vasto, Sonya; Di Rosa, Luigi; Baldassano, Sara] Univ Palermo, Dept Biol Chem & Pharmaceut Sci & Technol, Palermo, Italy.
   [Sabatino, Leo; Consentino, Beppe Benedetto; Vultaggio, Lorena] Univ Palermo, Dipartimento Sci Agr Alimentari & Forestali, Palermo, Italy.
   [Baldassano, Davide] Univ Palermo, Dept Promoting Hlth Maternal Infant Excellence & I, Palermo, Italy.
   [Caldarella, Rosalia] P Giaccone Univ Hosp, Dept Lab Med, Palermo, Italy.
C3 IZS Sicilia; University of Palermo; University of Palermo; University of
   Palermo
RP Baldassano, S (corresponding author), Univ Palermo, Dept Biol Chem & Pharmaceut Sci & Technol, Palermo, Italy.
EM sara.baldassano@unipa.it
RI Di Rosa, Luigi/X-2034-2019; Sabatino, Leo/S-2488-2019; Vasto,
   Sonya/I-4771-2013; Ferrantelli, Vincenzo/P-2827-2015
OI CONSENTINO, Beppe Benedetto/0000-0001-5539-2230; Vasto,
   Sonya/0000-0002-6033-4745; Ferrantelli, Vincenzo/0000-0002-4911-5074; Di
   rosa, Luigi/0000-0002-9954-6817
FU Experimental Zooprophylactic Institute; FFR [2022]
FX The author(s) declare financial support was received for the research,
   authorship, and/or publication of this article. This work was supported
   by Experimental Zooprophylactic Institute and FFR 2022 Grant to SB.
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NR 55
TC 4
Z9 4
U1 1
U2 4
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD DEC 22
PY 2023
VL 10
AR 1288064
DI 10.3389/fnut.2023.1288064
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA EB1X1
UT WOS:001136366100001
PM 38196756
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Behr-Roussel, D
   Oudot, A
   Caisey, S
   Coz, OLE
   Gorny, D
   Bernabé, J
   Wayman, C
   Alexandre, L
   Giuliano, FA
AF Behr-Roussel, Delphine
   Oudot, Alexandra
   Caisey, Stephanie
   Coz, Olivier L. E.
   Gorny, Diane
   Bernabe, Jacques
   Wayman, Chris
   Alexandre, Laurent
   Giuliano, Francois A.
TI Daily treatment with sildenafil reverses endothelial dysfunction and
   oxidative stress in an animal model of insulin resistance
SO EUROPEAN UROLOGY
LA English
DT Article
ID NITRIC-OXIDE SYNTHASE; PHOSPHODIESTERASE TYPE-5 INHIBITORS; ERECTILE
   DYSFUNCTION; METABOLIC SYNDROME; HYPERTENSIVE-RATS; FRUCTOSE; MARKERS;
   NITRATE; ASSOCIATION; ACTIVATION
AB Objectives: Patients with insulin resistance exhibit endothelial dysfunction with decreased nitric oxide (NO) production and increased oxidative stress. We postulated that daily sildenafil improved endothelial function in fructose-fed rats.
   Methods and results: Wistar rats were fed a standard or fructose-enriched diet (FFR) for 9 wk. From weeks 6-8, sildenafil was administered twice daily (sc, 20 m g/kg), followed by a 1-wk washout. Concentration-response curves (CRCs) to endothelium-dependent (acetylcholine [Ach] and A23187) and -independent (sodium nitroprusside [SNP]) relaxing agents were performed on isolated precontracted aortas and superior mesenteric arteries (SMAs). Vascular cyclic guanosine monophosphate (cGMP) content, urinary excretion of nitrates/ nitrites (NOx) and 8-isoprostanes (IPT), and plasma levels of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) were evaluated. Relaxations to ACh were significantly reduced in aortas and SMAs of FFR. Sildenafil restored ACh-induced relaxations in aortas and provoked a significant leftward shift of the CRC to ACh in SMAs, whereas it did not modify the enhanced relaxations to SNP in FFR. IL-6, TNF-alpha, vascular cGMP, and urinary NOx levels were not modified by the fructose or sildenafil treatment. Urinary IPT levels were significantly elevated in FFR and normalized by sildenafil.
   Conclusions: Endothelial dysfunction and oxidative stress associated with insulin resistance can be reversed by daily sildenafil, even 1 wk after treatment cessation. (c) 2008 European Association of Urology. Published by Elsevier B.V. All rights reserved.
C1 [Giuliano, Francois A.] Hop Raymond Poincare, Dept Phys Med & Rehabil, Neurouroandrol Unit, F-92380 Garches, France.
   [Behr-Roussel, Delphine; Oudot, Alexandra; Caisey, Stephanie; Coz, Olivier L. E.; Gorny, Diane; Bernabe, Jacques; Alexandre, Laurent] Pelvipharm, Domaine CNRS, F-91190 Gif Sur Yvette, France.
   [Wayman, Chris] Pfizer Global Res & Dev, Sandwich CT13 9NJ, Kent, England.
C3 Assistance Publique Hopitaux Paris (APHP); Hopital Universitaire
   Raymond-Poincare - APHP; Centre National de la Recherche Scientifique
   (CNRS); Pfizer; Pfizer United Kingdom
RP Giuliano, FA (corresponding author), Hop Raymond Poincare, Dept Phys Med & Rehabil, Neurouroandrol Unit, 104 Bd Raymond Poincare, F-92380 Garches, France.
EM giuliano@cyber-sante.org
RI Behr-Roussel, Delphine/AAT-3626-2020
OI OUDOT, Alexandra/0000-0002-1267-0293
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NR 40
TC 38
Z9 42
U1 0
U2 6
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0302-2838
EI 1873-7560
J9 EUR UROL
JI Eur. Urol.
PD JUN
PY 2008
VL 53
IS 6
BP 1272
EP 1281
DI 10.1016/j.eururo.2007.11.018
PG 10
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 312ZC
UT WOS:000256709900028
PM 18036727
DA 2025-06-11
ER

PT J
AU Coehoorn, CJ
   Danzy, J
   Bouchereau-Lal, N
   Adams, A
AF Coehoorn, Cory J.
   Danzy, Jillian
   Bouchereau-Lal, Naina
   Adams, Aaron
TI Rapid heat stress causes increased delta spectral power 24 h
   post-exposure and altered reaction time in firefighters by its dynamic
   ability to generate heat storage
SO FIRE SAFETY JOURNAL
LA English
DT Article
DE Heat stress; Firefighting; Electroencephalography; Hyperthermia; Neural
   function; Neurocognitive
ID SHORT-TERM-MEMORY; HYPERTHERMIA IMPAIRS; METABOLIC SYNDROME;
   DECISION-MAKING; METAANALYSIS; PERFORMANCE; ATTENTION; FITNESS; INDEX
AB This experiment determined the duration that rapid heat stress (RHS) impacts neural function and reaction time. Previous research has discovered that RHS results in neural function changes immediately post-exposure. No studies have evaluated the duration that these variables are impacted. Additionally, research has not assessed the impact of RHS on reaction time. We hypothesized that RHS would lead to sustained electroencephalography (EEG) spectral power and reaction time changes. Twenty participants performed a treadmill protocol in an environmental chamber (35 degrees C; 45% humidity) in firefighter personal protective equipment until reaching a core temperature of 39 degrees C. The subjects performed a Go/No-Go (response inhibition) task (pre-, post-, 24, and 48 h post-RHS) while EEG and reaction time were recorded. Results from the Go/No-Go task revealed a difference between pre-RHS and post-RHS delta spectral power. These differences support previous literature. The first novel finding of this study is that delta power is still perturbed 24 h post-RHS exposure. The second novel finding is that reaction time is altered post-RHS, 24 h, and 48 h post-RHS. These cognitive changes could result in compounded consequences if two bouts of RHS occur in 24 h (e.g., two fires or other hyperthermic events), which could jeopardize critical life-saving missions.
C1 [Coehoorn, Cory J.; Danzy, Jillian; Bouchereau-Lal, Naina] Louisiana State Univ Hlth Shreveport, Shreveport, LA USA.
   [Adams, Aaron] Louisiana State Univ Shreveport, Shreveport, LA USA.
   [Coehoorn, Cory J.] 1501 Kings Highway, Shreveport, LA 71115 USA.
C3 Louisiana State University System; Louisiana State University Health
   Sciences Center at Shreveport; Louisiana State University System;
   Louisiana State University Shreveport
RP Coehoorn, CJ (corresponding author), 1501 Kings Highway, Shreveport, LA 71115 USA.
EM cory.coehoorn@lsuhs.edu
RI Coehoorn, Cory/ABA-3497-2021
OI Coehoorn, Cory/0000-0002-5026-9548
FU Louisiana Biomedical Research Network (LBRN) Pilot Program;
   Institutional Development Award (IDeA) from the National Institute of
   General Medical Sciences of the National Institutes of Health [P2O
   GM103424-2]
FX We want to acknowledge research funding from the Louisiana Biomedical
   Research Network (LBRN) Pilot Program, supported by an Institutional
   Development Award (IDeA) from the National Institute of General Medical
   Sciences of the National Institutes of Health under grant number P2O
   GM103424-2. We would also like to thank all par-ticipants for
   volunteering for this research.
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NR 40
TC 2
Z9 2
U1 1
U2 2
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 0379-7112
EI 1873-7226
J9 FIRE SAFETY J
JI Fire Saf. J.
PD JUN
PY 2024
VL 146
AR 104126
DI 10.1016/j.firesaf.2024.104126
EA FEB 2024
PG 7
WC Engineering, Civil; Materials Science, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering; Materials Science
GA ON4C7
UT WOS:001207931100001
DA 2025-06-11
ER

PT J
AU Angelico, F
   Francioso, S
   Del Ben, M
   Feole, K
   Carbone, M
   Pignatelli, P
   Violi, F
   Angelico, M
AF Angelico, F.
   Francioso, S.
   Del Ben, M.
   Feole, K.
   Carbone, M.
   Pignatelli, P.
   Violi, F.
   Angelico, M.
TI Clinical trial: low plasma cholesterol and oxidative stress predict
   rapid virological response to standard therapy with peginterferon and
   ribavirin in HCV patients
SO ALIMENTARY PHARMACOLOGY & THERAPEUTICS
LA English
DT Article
ID CHRONIC HEPATITIS-C; INTERFERON-ALPHA-2B PLUS RIBAVIRIN;
   DENSITY-LIPOPROTEIN CHOLESTEROL; INSULIN-RESISTANCE; COMBINATION
   THERAPY; VIRUS GENOTYPE-2; ALPHA-2A; INFECTION; REPLICATION; STEATOSIS
AB P>Background
   Rapid virological response (RVR) is the best predictor of sustained response to standard HCV treatment.
   Aim
   To evaluate predictive factors of RVR.
   Methods
   Sixty-five patients (mean age 52.6 +/- 13.8; 37 genotype-1, and 28 genotypes-2/3) were consecutively treated with pegIFN-alpha2a or 2b once weekly plus daily ribavirin based on body weight for 24 or 48 weeks, according to genotype. RVR was defined as undetectable HCV-RNA at week 4.
   Results
   Twenty-seven percent of patients achieved RVR in genotypes 1 and 60.7% in genotypes 2/3 (P < 0.01). Rapid responders had higher mean serum baseline total and LDL-cholesterol levels (P < 0.01). RVR was 20.0% in the bottom tertile of total cholesterol and 63.6% in the top tertile (P < 0.01). HCV-RNA levels at week 4 were positively correlated with baseline serum insulin (P < 0.01), HOMA-IR (P < 0.01), body mass index (P < 0.05) and number of components of metabolic syndrome (P < 0.01) and negatively correlated with cholesterol levels (P < 0.05). At multivariate analysis, age, LDL-cholesterol, HCV genotype and serum 8-iso-PGF2alpha, a marker of oxidative stress, were independent predictors of RVR.
   Conclusions
   Our prospective study supports a role of low serum total and LDL-cholesterol and of oxidative stress as positive independent predictive factors of poor RVR in HCV patients.
C1 [Angelico, F.; Del Ben, M.; Feole, K.; Pignatelli, P.; Violi, F.] Sapienza Univ, Dept Expt Med, Div Internal Med C, I-00161 Rome, Italy.
   [Francioso, S.; Carbone, M.; Angelico, M.] Univ Roma Tor Vergata, Hepatol Unit, Rome, Italy.
C3 Sapienza University Rome; University of Rome Tor Vergata
RP Angelico, F (corresponding author), Sapienza Univ, Dept Expt Med, Div Internal Med C, Policlin Umberto 1,155 Viale Policlin, I-00161 Rome, Italy.
EM Francesco.angelico@uniroma1.it
RI Del Ben, Maria/AAE-7603-2020; Angelico, Francesco/AAB-6585-2020;
   Maurano, Francesco/H-6487-2013; pignatelli, pasquale/K-2116-2016; Violi,
   Francesco/K-1509-2016
OI CARBONE, MARCO/0000-0003-1445-0443; pignatelli,
   pasquale/0000-0002-2265-7455; ANGELICO, Mario/0000-0003-2883-9206;
   Violi, Francesco/0000-0002-6610-7068
CR Akuta N, 2007, J MED VIROL, V79, P1686, DOI 10.1002/jmv.20979
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NR 42
TC 13
Z9 13
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0269-2813
EI 1365-2036
J9 ALIMENT PHARM THER
JI Aliment. Pharmacol. Ther.
PD SEP 1
PY 2009
VL 30
IS 5
BP 444
EP 451
DI 10.1111/j.1365-2036.2009.04055.x
PG 8
WC Gastroenterology & Hepatology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Pharmacology & Pharmacy
GA 479IZ
UT WOS:000268654200003
PM 19493257
OA Bronze
DA 2025-06-11
ER

PT J
AU Zhang, JY
   Shen, YF
   Li, GS
   Zhang, F
   Yang, AL
   Li, JJ
   Pu, SY
   Huang, QQ
   Zhuang, BJ
   Yu, XJ
AF Zhang, Jingyi
   Shen, Yifeng
   Li, Guangsen
   Zhang, Feng
   Yang, Aili
   Li, Junjun
   Pu, Shiyun
   Huang, Qingqing
   Zhuang, Baojun
   Yu, Xujun
TI Bibliometrics and visualization analysis of literature on male
   hypogonadism from 2000 to 2023: research focus and frontiers
SO INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH
LA English
DT Review
ID OXIDATIVE STRESS; TESTOSTERONE; MEN; OBESITY; SECONDARY
AB Male hypogonadism can seriously affect male health and fertility, yet comprehensive bibliometric and visualization analyses of research in this area have been lacking. This study aimed to examine the distribution of literature, identify research hotspots, and discern development trends in male hypogonadism by analyzing 4026 English documents published between 2000 and 2023 using bibliometric and visual analyses. The results indicated a significant increase in publications and citations related to male hypogonadism over the past two decades, with the United States, the University of Florence, Maggi M, and the Journal of Clinical Endocrinology & Metabolism recognized as the most productive and highly cited country, institution, author, and journal, respectively. The article titled "The GPR54 gene as a regulator of puberty" received the highest number of citations. The keywords were categorized into four distinct clusters, including the etiology and pathogenesis of male hypogonadism, symptoms of late-onset hypogonadism, testosterone replacement therapy and its contraindications, the correlation between male hypogonadism and metabolic syndrome (MetS), obesity, and the epidemiology of male hypogonadism. The most frequently co-occurring keywords were "hypogonadism", "testosterone", and "men", while "oxidative stress" was the most prominent burst keyword. The analysis also identified "male infertility" and "oxidative stress" as the primary burst keywords in the last five years, indicating their emerging high-interest topics. Overall, this study provides a comprehensive overview of male hypogonadism research, offering valuable insights for researchers interested in this area, including potential collaborators, current research hotspots, and future research directions.
C1 [Zhang, Jingyi; Shen, Yifeng; Li, Guangsen; Zhang, Feng; Yang, Aili; Huang, Qingqing; Zhuang, Baojun; Yu, Xujun] Hosp Chengdu Univ Tradit Chinese Med, TCM Regulating Metab Dis Key Lab Sichuan Prov, Chengdu 610075, Peoples R China.
   [Li, Junjun; Pu, Shiyun] Chengdu Univ Tradit Chinese Med, Chengdu Peoples Hosp 5, Affiliated Peoples Hosp 5, Chengdu 611137, Peoples R China.
   [Yu, Xujun] Chengdu Univ Tradit Chinese Med, Sch Med & Life Sci, Chengdu 611137, Peoples R China.
C3 Chengdu University of Traditional Chinese Medicine; Chengdu University
   of Traditional Chinese Medicine; Chengdu University of Traditional
   Chinese Medicine
RP Yu, XJ (corresponding author), Hosp Chengdu Univ Tradit Chinese Med, TCM Regulating Metab Dis Key Lab Sichuan Prov, Chengdu 610075, Peoples R China.; Yu, XJ (corresponding author), Chengdu Univ Tradit Chinese Med, Sch Med & Life Sci, Chengdu 611137, Peoples R China.
EM 20639179@qq.com
RI 杨, 爱利/GRR-1840-2022; Zhuang, BaoJun/KRQ-1547-2024; Li,
   Jun/HTN-0647-2023; Pu, Shiyun/ISU-9896-2023
OI Li, Junjun/0000-0002-2956-9079; Zhuang, BaoJun/0000-0002-3094-282X;
   Zhang, Jingyi/0000-0002-7977-0336; yu, xujun/0000-0002-5620-6783
FU National Natural Science Foundation of China [82274325]; Special Project
   of Sichuan Provincial Administration of Traditional Chinese Medicine for
   Scientific Research of Traditional Chinese Medicine [2021MS474]
FX This study was supported by the National Natural Science Foundation of
   China (Award Number: 82274325, Recipient: Xujun Yu) and Special Project
   of Sichuan Provincial Administration of Traditional Chinese Medicine for
   Scientific Research of Traditional Chinese Medicine (Award Number:
   2021MS474, Recipient: Guangsen Li).
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NR 42
TC 2
Z9 2
U1 3
U2 18
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0955-9930
EI 1476-5489
J9 INT J IMPOT RES
JI Int. J. Impot. Res.
PD JUN
PY 2024
VL 36
IS 4
BP 312
EP 323
DI 10.1038/s41443-023-00803-4
EA DEC 2023
PG 12
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA SG7Y9
UT WOS:001114306700001
PM 38052978
DA 2025-06-11
ER

PT J
AU Costa-Urrutia, P
   Flores-Buendía, AM
   Ascencio-Montiel, I
   Solares-Tlapechco, J
   Medina-Campos, ON
   Pedraza-Chaverri, J
   Granados, J
   Jiménez-Osorio, AS
   Rodríguez-Arellano, ME
AF Costa-Urrutia, Paula
   Mariana Flores-Buendia, Aline
   Ascencio-Montiel, Ivan
   Solares-Tlapechco, Jacqueline
   Noel Medina-Campos, Omar
   Pedraza-Chaverri, Jose
   Granados, Julio
   Sarai Jimenez-Osorio, Angelica
   Eunice Rodriguez-Arellano, Martha
TI Antioxidant Enzymes Haplotypes and Polymorphisms Associated with Obesity
   in Mexican Children
SO ANTIOXIDANTS
LA English
DT Article
DE antioxidant enzymes; polymorphisms; children obesity
ID OXIDATIVE STRESS; PARAOXONASE ACTIVITY; METABOLIC SYNDROME; CHILDHOOD
   OBESITY; RISK; DYSFUNCTION
AB Obesity is a major health problem worldwide and constitutes a sanitary emergency in Mexico, especially childhood obesity. Several studies have proved the relationship between obesity and oxidative stress and the influence of genetic predisposition. This work was aimed to analyze the association of antioxidant enzyme polymorphisms with overweight and obesity in Mexican children and adolescents. A case-control study was performed in 585 children and adolescents aged 3 to 17 years, using two criteria to classify obesity: body mass index (BMI) and body fat percentage (BFP). Anthropometric and biochemical measurements were carried out, and malondialdehyde serum levels were determined. Genotyping was done with the Axiom Genome-Wide LAT microarray, including 68 single nucleotide polymorphisms (SNPs) of the glutathione peroxidase (GPX) and paraoxonase (PON) families. We found six haplotypes associated with obesity-two of them (one in GPX3 and the other in GPX5 and GPX6) in a protective direction when obesity was classified by BMI. The other four haplotypes were associated with obesity when classification was based on BFP-one of them in GPX3 in a protective direction and the others in PON genes conferring obesity risk. In addition, two SNPs, GPX3 rs922429 and GPX4 rs2074451 showed protection against obesity classified by BFP. This study showed genetic susceptibility to oxidative stress in relation to obesity in Mexican children and opens up the possibility that some genetic loci related to obesity are not identified when weight classification is based on BMI.
C1 [Costa-Urrutia, Paula; Mariana Flores-Buendia, Aline; Solares-Tlapechco, Jacqueline; Sarai Jimenez-Osorio, Angelica; Eunice Rodriguez-Arellano, Martha] Hosp Reg Lic Adolfo Lopez Mateos, Lab Med Genom, ISSSTE, Ciudad De Mexico 01030, Mexico.
   [Mariana Flores-Buendia, Aline; Noel Medina-Campos, Omar; Pedraza-Chaverri, Jose] Univ Nacl Autonoma Mexico, Fac Quim, Dept Biol, Ciudad De Mexico 04510, Mexico.
   [Ascencio-Montiel, Ivan] Inst Mexicano Seguro Social, Coordinac Vigilancia Epidemiol, 120 Mier & Pesado St, Ciudad De Mexico 03100, Mexico.
   [Granados, Julio] Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Trasplantes, Div Inmunogenet, Ciudad De Mexico 14080, Mexico.
C3 Universidad Nacional Autonoma de Mexico; Instituto Mexicano del Seguro
   Social; Instituto Nacional de Ciencias Medicas y Nutricion Salvador
   Zubiran - Mexico
RP Jiménez-Osorio, AS; Rodríguez-Arellano, ME (corresponding author), Hosp Reg Lic Adolfo Lopez Mateos, Lab Med Genom, ISSSTE, Ciudad De Mexico 01030, Mexico.
EM paula.costa.urrutia@gmail.com; alinefloresbuendia@gmail.com;
   ivan-ascencio@hotmail.com; jsoltlapechco@gmail.com;
   omarnoelmedina@gmail.com; pedraza@unam.mx; julgrate@yahoo.com;
   jimenez.osorio.as@gmail.com; marthaeunicer@gmail.com
RI de Jesús Ascencio-Montiel, Iván/K-1582-2019; Jiménez-Osorio,
   Angélica/X-7119-2019; RODRIGUEZ ARELLANO, MARTHA EUNICE/G-3974-2017
OI Costa-Urrutia, Paula/0000-0002-6747-5380; Medina-Campos, Omar
   Noel/0000-0001-8264-0412; Ascencio-Montiel, Ivan de
   Jesus/0000-0001-7034-0586; RODRIGUEZ ARELLANO, MARTHA
   EUNICE/0000-0002-2135-6175; Jimenez-Osorio, Angelica
   Sarai/0000-0001-5108-0205
FU  [ISSSTE-E015];  [247.2012]
FX This research was funded by ISSSTE-E015, grant number 247.2012.
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NR 37
TC 9
Z9 10
U1 0
U2 11
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD AUG
PY 2020
VL 9
IS 8
AR 684
DI 10.3390/antiox9080684
PG 10
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA NH5AS
UT WOS:000564683200001
PM 32752212
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Spahis, S
   Delvin, E
   Borys, JM
   Levy, E
AF Spahis, Schohraya
   Delvin, Edgard
   Borys, Jean-Michel
   Levy, Emile
TI Oxidative Stress as a Critical Factor in Nonalcoholic Fatty Liver
   Disease Pathogenesis
SO ANTIOXIDANTS & REDOX SIGNALING
LA English
DT Review
DE liver steatosis; cardiometabolic disorders; mitochondria; antioxidants;
   treatment; reactive oxygen species
ID ENDOPLASMIC-RETICULUM STRESS; SENESCENCE MARKER PROTEIN-30; ATTENUATES
   HEPATIC STEATOSIS; OXYGEN SPECIES GENERATION; LOW-DENSITY-LIPOPROTEIN;
   VITAMIN-D DEFICIENCY; KAPPA-B ACTIVATION; INSULIN-RESISTANCE;
   MITOCHONDRIAL DYSFUNCTION; METABOLIC SYNDROME
AB Significance: Nonalcoholic fatty liver disease (NAFLD), characterized by liver triacylglycerol build-up, has been growing in the global world in concert with the raised prevalence of cardiometabolic disorders, including obesity, diabetes, and hyperlipemia. Redox imbalance has been suggested to be highly relevant to NAFLD pathogenesis.
   Recent Advances: As a major health problem, NAFLD progresses to the more severe nonalcoholic steatohepatitis (NASH) condition and predisposes susceptible individuals to liver and cardiovascular disease. Although NAFLD represents the predominant cause of chronic liver disorders, the mechanisms of its development and progression remain incompletely understood, even if various scientific groups ascribed them to the occurrence of insulin resistance, dyslipidemia, inflammation, and apoptosis. Nevertheless, oxidative stress (OxS) more and more appears as the most important pathological event during NAFLD development and the hallmark between simple steatosis and NASH manifestation.
   Critical Issues: The purpose of this article is to summarize recent developments in the understanding of NAFLD, essentially focusing onOxS as amajor pathogenetic mechanism. Various attempts to translate reactive oxygen species (ROS) scavenging by antioxidants into experimental and clinical studies have yielded mostly encouraging results.
   Future Directions: Although augmented concentrations of ROS and faulty antioxidant defense have been associated to NAFLD and related complications, mechanisms of action and proofs of principle should be highlighted to support the causative role of OxS and to translate its concept into the clinic.
C1 [Spahis, Schohraya; Delvin, Edgard; Levy, Emile] Univ Montreal, CHU Ste Justine, Res Ctr, GI Nutr Unit, 3175 Cote Ste Catherine, Montreal, PQ H3T 1C5, Canada.
   [Spahis, Schohraya; Levy, Emile] Univ Montreal, Dept Nutr, Montreal, PQ, Canada.
   [Delvin, Edgard] Univ Montreal, Dept Biochem, Montreal, PQ, Canada.
   [Borys, Jean-Michel; Levy, Emile] EPODE Int Network, Paris, France.
C3 Universite de Montreal; Universite de Montreal; Universite de Montreal
RP Levy, E (corresponding author), Univ Montreal, CHU Ste Justine, Res Ctr, GI Nutr Unit, 3175 Cote Ste Catherine, Montreal, PQ H3T 1C5, Canada.
EM emile.levy@recherche-ste-justine.qc.ca
FU JA deSeve Research Chair in nutrition; FRQS doctoral Scholarship Award
FX The current work was supported by research grants from the JA deSeve
   Research Chair in nutrition (E.L.) and the FRQS doctoral Scholarship
   Award (S.S.).
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NR 256
TC 300
Z9 317
U1 3
U2 150
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1523-0864
EI 1557-7716
J9 ANTIOXID REDOX SIGN
JI Antioxid. Redox Signal.
PD APR
PY 2017
VL 26
IS 10
BP 519
EP +
DI 10.1089/ars.2016.6776
PG 24
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA EP7PX
UT WOS:000397570800003
PM 27452109
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Favre, GA
   Esnault, VLM
   Van Obberghen, E
AF Favre, Guillaume A.
   Esnault, Vincent L. M.
   Van Obberghen, Emmanuel
TI Modulation of glucose metabolism by the renin-angiotensin-aldosterone
   system
SO AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
LA English
DT Review
DE renin-angiotensin-aldosterone system; insulin resistance; insulin target
   tissues; white adipose tissue; obesity
ID INDUCED INSULIN-RESISTANCE; WHITE ADIPOSE-TISSUE; II TYPE-1 RECEPTOR;
   CONVERTING-ENZYME-INHIBITION; BODY-WEIGHT GAIN; INCREASED
   ENERGY-EXPENDITURE; DIET-INDUCED OBESITY; FATTY LIVER-DISEASE;
   SKELETAL-MUSCLE; OXIDATIVE STRESS
AB The renin-angiotensin-aldosterone system (RAAS) is an enzymatic cascade functioning in a paracrine and autocrine fashion. In animals and humans, RAAS intrinsic to tissues modulates food intake, metabolic rate, adiposity, insulin sensitivity, and insulin secretion. A large array of observations shows that dysregulation of RAAS in the metabolic syndrome favors type 2 diabetes. Remarkably, angiotensin-converting enzyme inhibitors, suppressing the synthesis of angiotensin II (ANG II), and angiotensin receptor blockers, targeting the ANG II type 1 receptor, prevent diabetes in patients with hypertensive or ischemic cardiopathy. These drugs interrupt the negative feedback loop of ANG II on the RAAS cascade, which results in increased production of angiotensins. In addition, they change the tissue expression of RAAS components. Therefore, the concept of a dual axis of RAAS regarding glucose homeostasis has emerged. The RAAS deleterious axis increases the production of inflammatory cytokines and raises oxidative stress, exacerbating the insulin resistance and decreasing insulin secretion. The beneficial axis promotes adipogenesis, blocks the production of inflammatory cytokines, and lowers oxidative stress, thereby improving insulin sensitivity and secretion. Currently, drugs targeting RAAS are not given for the purpose of preventing diabetes in humans. However, we anticipate that in the near future the discovery of novel means to modulate the RAAS beneficial axis will result in a decisive therapeutic breakthrough.
C1 [Favre, Guillaume A.; Esnault, Vincent L. M.; Van Obberghen, Emmanuel] IRCAN, INSERM, U1081, Aging & Diabet Team, F-06107 Nice 2, France.
   [Favre, Guillaume A.; Esnault, Vincent L. M.; Van Obberghen, Emmanuel] IRCAN, CNRS, UMR7284, F-06107 Nice 2, France.
   [Favre, Guillaume A.; Esnault, Vincent L. M.; Van Obberghen, Emmanuel] Univ Nice Sophia Antipolis, F-06189 Nice, France.
   [Favre, Guillaume A.; Esnault, Vincent L. M.] Univ Hosp, Dept Nephrol, Nice, France.
   [Van Obberghen, Emmanuel] Univ Hosp, Clin Chem Lab, Nice, France.
C3 Universite Cote d'Azur; Institut National de la Sante et de la Recherche
   Medicale (Inserm); Institut National de la Sante et de la Recherche
   Medicale (Inserm); Universite Cote d'Azur; Centre National de la
   Recherche Scientifique (CNRS); CNRS - National Institute for Biology
   (INSB); Universite Cote d'Azur; CHU Nice; CHU Nice
RP Favre, GA (corresponding author), IRCAN, 28 Ave Valombrose, F-06107 Nice 2, France.
EM favre@unice.fr
OI Esnault, Vincent, Louis, Marie/0000-0002-7418-5672
FU INSERM; Universite de Nice Sophia Antipolis; Conseil Regional PACA;
   Conseil General des Alpes-Maritimes; European Foundation for the Study
   of Diabetes (EFSD/Lilly); Fresenius Medical Care and
   Aviesan/AstraZeneca; Diabetes and Vessel Wall Injury Program; Agence
   Nationale de la Recherche (ANR) [RPV12004AAA]
FX Our research was supported by INSERM, Universite de Nice Sophia
   Antipolis, Conseil Regional PACA, and Conseil General des
   Alpes-Maritimes, by the European Foundation for the Study of Diabetes
   (EFSD/Lilly; European Diabetes Research Programme, 2011), by Fresenius
   Medical Care and Aviesan/AstraZeneca, by the Diabetes and Vessel Wall
   Injury Program, and by the Agence Nationale de la Recherche (ANR blanc
   no. RPV12004AAA).
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NR 197
TC 86
Z9 90
U1 0
U2 17
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0193-1849
EI 1522-1555
J9 AM J PHYSIOL-ENDOC M
JI Am. J. Physiol.-Endocrinol. Metab.
PD MAR 15
PY 2015
VL 308
IS 6
BP E435
EP E449
DI 10.1152/ajpendo.00391.2014
PG 15
WC Endocrinology & Metabolism; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Physiology
GA CD4OI
UT WOS:000351062500001
PM 25564475
DA 2025-06-11
ER

PT J
AU Meichtry, LB
   Sotelo, MB
   Musachio, EAS
   Janner, DE
   Dahleh, MMM
   Fernandes, EJ
   Bortolotto, VC
   Guerra, GP
   Prigol, M
AF Meichtry, Luana Barreto
   Sotelo, Magna Barrientos
   Musachio, Elize Aparecida Santos
   Janner, Dieniffer Espinosa
   Dahleh, Mustafa Munir Mustafa
   Fernandes, Eliana Jardim
   Bortolotto, Vandreza Cardoso
   Guerra, Gustavo Petri
   Prigol, Marina
TI Early exposure to trans fat causes cognitive impairment by modulating
   the expression of proteins associated with oxidative stress and synaptic
   plasticity in Drosophila melanogaster
SO COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
LA English
DT Article
DE Trans fatty acid; Oxidative stress; Cognitive impairment; Neuronal
   membranes; Permeability; Signaling
ID METABOLIC SYNDROME; MEMORY; GLUTATHIONE; DIET; ALTERS; HIPPOCAMPUS;
   ASSAY; ACIDS; NRF2
AB Evidence has shown that consuming trans fatty acids (TFA) during development leads to their incorporation into the nervous tissue, resulting in neurological changes in flies. In this study, Drosophila melanogaster was exposed to different concentrations of hydrogenated vegetable fat (HVF) during development: substitute hydrogenated vegetable fat (SHVF), HVF 10 %, and HVF 20 %. The objective was to evaluate the effects of early trans fat exposure on cognition and associated pathways in flies. The results showed that early TFA exposure provoked a cerebral redox imbalance, as confirmed by increased reactive species (HVF 10 and 20 %) and lipid peroxidation (SHVF, HVF 10, and 20 %), reduced nuclear factor erythroid 2 -related factor 2 immunoreactivity (HVF 10 and 20 %), and increased heat shock protein 70 (HVF 20 %), which was possibly responsible for decreasing superoxide dismutase (SHVF, HVF 10, and 20 %) and catalase (HVF 20 %) activities. Furthermore, the presence of TFA in nervous tissue impaired learning (HVF 10 and 20 %) and memory at 6 and 24 h (SHVF, HVF 10, and 20 %). These cognitive impairments may be linked to reduced Shank levels (HVF 20 %) and increased acetylcholinesterase activity (SHVF, HVF 10 and 20 %) observed. Our findings demonstrate that early exposure to trans fat leads to cerebral redox imbalance, altering proteins associated with stress, synaptic plasticity, and the cholinergic system, consequently leading to cognitive impairment in flies.
C1 [Meichtry, Luana Barreto; Musachio, Elize Aparecida Santos; Janner, Dieniffer Espinosa; Dahleh, Mustafa Munir Mustafa; Fernandes, Eliana Jardim; Bortolotto, Vandreza Cardoso; Guerra, Gustavo Petri; Prigol, Marina] Fed Univ Pampa, Lab Pharmacol & Toxicol Evaluat Appl Bioact Mol La, Campus Itaqui, BR-97650000 Itaqui, RS, Brazil.
   [Sotelo, Magna Barrientos] Univ Fed Rio Grande do Sul, Inst Food Sci & Technol, BR-91501970 Porto Alegre, RS, Brazil.
   [Prigol, Marina] Univ Fed Pampa, Campus Itaqui,Rua Luiz Joaquim de Sa Britto S-N, BR-97650000 Itaqui, RS, Brazil.
C3 Universidade Federal do Pampa; Universidade Federal do Rio Grande do
   Sul; Universidade Federal do Pampa
RP Prigol, M (corresponding author), Univ Fed Pampa, Campus Itaqui,Rua Luiz Joaquim de Sa Britto S-N, BR-97650000 Itaqui, RS, Brazil.
EM marinaprigol@gmail.com
RI Petri Guerra, Gustavo/AGQ-7865-2022; Dahleh, Mustafa/AAG-1793-2021;
   Janner, Dieniffer/LUY-1156-2024; Prigol, Marina/E-9316-2015
OI Espinosa Janner, Dieniffer/0000-0003-1219-5063
FU Higher Education Personnel Improvement Coordination (CAPES) [001];
   National Council for Scientific and Technological Development (CNPq) [PQ
   308120/2020-5]; Research Support Foundation of the State of Rio Grande
   do Sul (FAPERGS) [PQG19/2551-0001913-0]
FX This work was supported by grants from the Higher Education Personnel
   Improvement Coordination (CAPES) (001) , the National Council for
   Scientific and Technological Development (CNPq) (PQ 308120/2020-5) , and
   the Research Support Foundation of the State of Rio Grande do Sul
   (FAPERGS) (PQG19/2551-0001913-0) .
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NR 60
TC 3
Z9 3
U1 1
U2 2
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1532-0456
EI 1878-1659
J9 COMP BIOCHEM PHYS C
JI Comp. Biochem. Physiol. C-Toxicol. Pharmacol.
PD MAY
PY 2024
VL 279
AR 109858
DI 10.1016/j.cbpc.2024.109858
EA FEB 2024
PG 10
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism;
   Toxicology; Zoology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism;
   Toxicology; Zoology
GA NT7T6
UT WOS:001202778900001
PM 38369039
DA 2025-06-11
ER

PT J
AU Caudet, J
   Trelis, M
   Cifre, S
   Tapia, G
   Soriano, JM
   Rodrigo, R
   Merino-Torres, JF
AF Caudet, Jana
   Trelis, Maria
   Cifre, Susana
   Tapia, Gabriela
   Soriano, Jose M.
   Rodrigo, Regina
   Merino-Torres, Juan F.
TI Do Intestinal Unicellular Parasites Have a Role in the Inflammatory and
   Redox Status among the Severely Obese?
SO ANTIOXIDANTS
LA English
DT Article
DE obesity; lipoinflammation; oxidative stress; antioxidant defense;
   Blastocystis; Giardia intestinalis; Dientamoeba fragilis; food
   antioxidants
ID INCREASED OXIDATIVE STRESS; SECRETORY IMMUNE-RESPONSE;
   NECROSIS-FACTOR-ALPHA; INSULIN-RESISTANCE; LIPID-PEROXIDATION; METABOLIC
   SYNDROME; PROTEIN; ASSOCIATION; EXPRESSION; BIOMARKERS
AB The diagnosis of obesity comprises subjects with totally different phenotypes and metabolic profiles. Systemic inflammation and oxidative stress derived from the white adipose tissue are suggested as the link between this disease and the development of insulin resistance and metabolic comorbidities. The presence of unicellular eukaryotic parasites colonizing the human gut ecosystem is a common circumstance, and yet their influence on the inflammatory and redox status of the obese host has not been assessed. Herein, a set of inflammatory and redox biomarkers were assessed together with a parasitological analysis of 97 severely obese subjects. Information was also collected on insulin resistance and on the antioxidant composition of the diet. The global prevalence of intestinal unicellular parasites was 49.5%, with Blastocystis sp. the most prevalent protozoan found (42.3%). Colonized subjects displayed a higher total antioxidant capacity and a trend towards higher extracellular superoxide dismutase activity, regardless of their insulin resistance status, along with lower reduced glutathione/oxidized glutathione (GSH/GSSG) ratios in plasma in the insulin-resistant subgroup. No changes in malondialdehyde levels, or in inflammatory cytokines in plasma, were found in regard to the colonization status. In conclusion, enteric eukaryotic unicellular parasites may play an important role in modulating the antioxidant defenses of an obese host, thus could have beneficial effects with respect to the development of systemic metabolic disorders.
C1 [Caudet, Jana; Merino-Torres, Juan F.] Univ & Polytech Hosp La Fe, Dept Endocrinol & Nutr, Valencia 46026, Spain.
   [Caudet, Jana; Trelis, Maria; Cifre, Susana; Soriano, Jose M.; Rodrigo, Regina; Merino-Torres, Juan F.] Univ Valencia, Joint Res Unit Endocrinol Nutr & Clin Dietet, Hlth Res Inst Hosp La Fe, Valencia 46026, Spain.
   [Trelis, Maria; Tapia, Gabriela] Univ Valencia, Parasite & Hlth Res Grp, Area Parasitol, Dept Pharm & Pharmaceut Technol & Parasitol, Valencia 46010, Spain.
   [Soriano, Jose M.] Univ Valencia, Food & Hlth Lab, Inst Mat Sci, Valencia 46980, Spain.
   [Rodrigo, Regina] Principe Felipe Res Ctr CIPF, Pathophysiol & Therapies Vis Disorders, Valencia 46012, Spain.
   [Rodrigo, Regina] CIPF Hlth Res Inst Hosp La Fe, Joint Res Unit Rare Dis, Valencia 46012, Spain.
   [Rodrigo, Regina] Inst Salud Carlos III, Ctr Biomed Res Rare Dis CIBERER, Madrid 28029, Spain.
   [Rodrigo, Regina] Univ Valencia, Dept Physiol, Valencia 46010, Spain.
   [Merino-Torres, Juan F.] Univ Valencia, Dept Med, Fac Med, Valencia 46010, Spain.
C3 University of Valencia; University of Valencia; University of Valencia;
   Prince Felipe Research Center; CIBER - Centro de Investigacion Biomedica
   en Red; CIBERER; Instituto de Salud Carlos III; University of Valencia;
   University of Valencia
RP Caudet, J (corresponding author), Univ & Polytech Hosp La Fe, Dept Endocrinol & Nutr, Valencia 46026, Spain.; Caudet, J; Trelis, M (corresponding author), Univ Valencia, Joint Res Unit Endocrinol Nutr & Clin Dietet, Hlth Res Inst Hosp La Fe, Valencia 46026, Spain.; Trelis, M (corresponding author), Univ Valencia, Parasite & Hlth Res Grp, Area Parasitol, Dept Pharm & Pharmaceut Technol & Parasitol, Valencia 46010, Spain.
EM janacaudet@gmail.com; maria.trelis@uv.es
RI Soriano, Jose/AAA-4158-2019; Tapia, Gabriela/LPQ-1641-2024; Rodrigo,
   Regina/I-1868-2015; Merino-Torres, Juan Francisco/T-8698-2018; TRELIS,
   MARIA/K-6021-2014
OI Rodrigo, Regina/0000-0001-5875-986X; Soriano, Jose/0000-0003-2846-1311;
   Tapia Veloz, Gabriela Elizabeth/0000-0002-3170-1008; Caudet,
   Jana/0000-0002-0124-1100; Merino-Torres, Juan
   Francisco/0000-0002-0191-4504; TRELIS, MARIA/0000-0002-5977-3337; Cifre,
   Susana/0000-0003-1975-5828
FU La Fe Health Research Institute [2014/0396, 2015/0359]
FX This study was supported by La Fe Health Research Institute (research
   grants: 2014/0396 and 2015/0359).
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NR 89
TC 3
Z9 3
U1 1
U2 5
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD NOV
PY 2022
VL 11
IS 11
AR 2090
DI 10.3390/antiox11112090
PG 18
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA 6A5IK
UT WOS:000880689000001
PM 36358463
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Mirmiranpour, H
   Mousavizadeh, M
   Noshad, S
   Ghavami, M
   Ebadi, M
   Ghasemiesfe, M
   Nakhjavani, M
   Esteghamati, A
AF Mirmiranpour, Hossein
   Mousavizadeh, Mostafa
   Noshad, Sina
   Ghavami, Mojgan
   Ebadi, Maryam
   Ghasemiesfe, Mehrnaz
   Nakhjavani, Manouchehr
   Esteghamati, Alireza
TI Comparative effects of pioglitazone and metformin on oxidative stress
   markers in newly diagnosed type 2 diabetes patients: A randomized
   clinical trial
SO JOURNAL OF DIABETES AND ITS COMPLICATIONS
LA English
DT Article
DE Metformin; Pioglitazone; Oxidative stress markers; Antioxidants
ID LIPOPROTEIN-LIPASE MASS; ACTIVATED RECEPTOR-GAMMA; PREHEPARIN SERUM;
   LIPID-PEROXIDATION; METABOLIC SYNDROME; ANTIOXIDANT; COMPLICATIONS;
   GENERATION; MELLITUS; LEUKOCYTES
AB Aims: Recent studies have suggested that pioglitazone exerts anti-oxidant properties which may countervail oxidative stress (OS). We aimed to elucidate the effects of pioglitazone on OS modulation and to compare its effects with metformin.
   Methods: Data from the randomized clinical trial (registration no.NCT01521624) were used. Newly diagnosed type 2 diabetes patients were assigned to pioglitazone 30 mg daily (n = 30), metformin 1000 mg daily (n = 50), or no medication (n = 49). Recommendations for exercise and dietary modifications were provided for three groups. Serum concentrations of advanced oxidation protein products(AOPP), advanced glycation end products(AGE), ferritin reducing ability of plasma(FRAP), and enzymatic activities of paraoxonase(PON), lecithin-cholesterol asyltransferase(LCAT), and lipoprotein lipase(LPL) were measured at baseline and after three months.
   Results: In comparison with no medication, pioglitazone proved to be superior in OS amelioration (p < 0.05 in all analyses). Compared with metformin, both medications were equally effective in decrement of AOPP and AGE, along with increment of PON (p = 0.688, 0.140, and 0.273, respectively). FRAP concentrations increased significantly with metformin (p = 0.012). On the other hand, pioglitazone yielded better efficacy in restoration of LCAT and LPL enzymatic activities (p = 0.037, and <0.001, respectively).
   Conclusions: Similar to metformin, three months treatment with Pioglitazone is beneficial in terms of OS alleviation and anti-oxidant capacity restoration. (C) 2013 Elsevier Inc. All rights reserved.
C1 [Mirmiranpour, Hossein; Mousavizadeh, Mostafa; Noshad, Sina; Ghavami, Mojgan; Ebadi, Maryam; Ghasemiesfe, Mehrnaz; Nakhjavani, Manouchehr; Esteghamati, Alireza] Univ Tehran Med Sci, Vali Asr Hosp, Sch Med, EMRC, Tehran, Iran.
C3 Tehran University of Medical Sciences
RP Esteghamati, A (corresponding author), Univ Tehran Med Sci, Vali Asr Hosp, EMRC, POB 13145-784, Tehran, Iran.
EM h_mirmiranpoor@yahoo.com; s.m.mousavizadeh@gmail.com;
   sina.noshad@gmail.com; mojgan.sa.ghavami@gmail.com;
   ebadi.mary@yahoo.com; m-ghasemi@razi.tums.ac.ir; nakhjavanim@tums.ac.ir;
   esteghamati@tums.ac.ir
RI Nakhjavani, Manouchehr/J-3704-2019; Mousavizadeh, Mostafa/IYJ-3801-2023;
   Ghavami, Mojgan/KIC-7136-2024; Mirmiranpour, Hossein/U-6611-2017
OI Mirmiranpour, Hossein/0000-0001-7666-0900; Mousavizadeh,
   Mostafa/0000-0002-1914-697X; Ghavami, Mojgan/0000-0003-1292-3374;
   mousavizadeh, kazem/0000-0002-4213-5523
FU Tehran University of Medical Sciences
FX This study was funded by Tehran University of Medical Sciences
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NR 29
TC 43
Z9 45
U1 0
U2 8
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1056-8727
EI 1873-460X
J9 J DIABETES COMPLICAT
JI J. Diabetes Complications
PD SEP-OCT
PY 2013
VL 27
IS 5
BP 501
EP 507
DI 10.1016/j.jdiacomp.2013.05.006
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 229WX
UT WOS:000325299700016
PM 23891275
DA 2025-06-11
ER

PT J
AU Erceg, S
   Munjas, J
   Sopic, M
   Tomasevic, R
   Mitrovic, M
   Kotur-Stevuljevic, J
   Mamic, M
   Vujcic, S
   Klisic, A
   Ninic, A
AF Erceg, Sanja
   Munjas, Jelena
   Sopic, Miron
   Tomasevic, Ratko
   Mitrovic, Milos
   Kotur-Stevuljevic, Jelena
   Mamic, Milica
   Vujcic, Sanja
   Klisic, Aleksandra
   Ninic, Ana
TI Expression Analysis of Circulating miR-21, miR-34a and miR-122 and Redox
   Status Markers in Metabolic Dysfunction-Associated Steatotic Liver
   Disease Patients with and Without Type 2 Diabetes
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE MASLD; circulating miRNA; oxidative stress; redox status; type 2
   diabetes
ID ISCHEMIA-MODIFIED ALBUMIN; HEPATIC STELLATE CELLS; FATTY; MICRORNAS;
   SERUM; MECHANISMS; OBESITY; STRESS; CANCER
AB Metabolic dysfunction-associated steatotic liver disease (MASLD), a hepatic form of metabolic syndrome, often co-occurs with type 2 diabetes (T2D) and now affects approximately 30% of the global population. MASLD encompasses conditions from simple steatosis to metabolic dysfunction-associated steatohepatitis, with oxidative stress (OS) driving progression through inflammation. This study analyzes the expression levels of circulating miRNAs and redox status markers in MASLD patients with and without T2D, exploring their potential as disease biomarkers. The expressions of miR-21, miR-34a, and miR-122 were analyzed in the platelet-poor plasma of 147 participants, divided into three groups: MASLD + T2D (48), MASLD (50), and a control group (49). Total oxidant status (TOS), total antioxidant status (TAS), ischemia-modified albumin (IMA), and superoxide anion radical (O2 center dot-) were measured in serum and plasma. Logistic regression showed that miR-21, miR-34a, TOS, TAS, O2 center dot-, and IMA were positive predictors of MASLD, while miR-21 and TAS were negative predictors of T2D in MASLD. Although miR-122 did not show a significant association with either condition, in combination with miR-34a and other markers such as lipid status and liver enzymes, a new significant predictor of MASLD was identified. Circulating miRNAs in combination with redox status markers, lipid status and liver enzymes show potential as MASLD biomarkers.
C1 [Erceg, Sanja; Munjas, Jelena; Sopic, Miron; Kotur-Stevuljevic, Jelena; Vujcic, Sanja; Ninic, Ana] Univ Belgrade, Fac Pharm, Dept Med Biochem, Belgrade 11221, Serbia.
   [Tomasevic, Ratko] Univ Belgrade, Fac Med, Belgrade 11000, Serbia.
   [Tomasevic, Ratko] Clin Hosp Ctr Zemun, Dept Gastroenterol & Hepatol, Clin Internal Med, Belgrade 11080, Serbia.
   [Mitrovic, Milos] Univ Med Ctr Zvezdara, Clin Dept Gastroenterol & Hepatol, Belgrade 11120, Serbia.
   [Mamic, Milica] Clin Hosp Ctr Zemun, Dept Lab Diagnost, Belgrade 11080, Serbia.
   [Klisic, Aleksandra] Univ Montenegro, Fac Med, Podgorica 81000, Montenegro.
   [Klisic, Aleksandra] Primary Hlth Care Ctr, Ctr Lab Diagnost, Podgorica 81000, Montenegro.
C3 University of Belgrade; University of Belgrade; University of Montenegro
RP Ninic, A (corresponding author), Univ Belgrade, Fac Pharm, Dept Med Biochem, Belgrade 11221, Serbia.
EM sanja.erceg@pharmacy.bg.ac.rs; jelenaj@pharmacy.bg.ac.rs;
   miron.sopic@pharmacy.bg.ac.rs; ratko.tomasevic@med.bg.ac.rs;
   dr.milosh.mitrovic@gmail.com; jelena.kotur@pharmacy.bg.ac.rs;
   mamicmilics8@gmail.com; sanjavujcic@icloud.com;
   aleksandranklisic@gmail.com; ana.ninic@pharmacy.bg.ac.rs
RI Klisic, Aleksandra/ABC-9219-2020; Munjas, Jelena/AAQ-1753-2020
OI Erceg, Sanja/0000-0002-7229-9406
FU Ministry of Science, Technological Development and Innovation, Republic
   of Serbia;  [451-03-65/2024-03/200161]
FX This research was funded by the Ministry of Science, Technological
   Development and Innovation, Republic of Serbia (Grant Agreement with
   University of Belgrade-Faculty of Pharmacy No:
   451-03-65/2024-03/200161).
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NR 63
TC 0
Z9 0
U1 0
U2 0
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD MAR 7
PY 2025
VL 26
IS 6
AR 2392
DI 10.3390/ijms26062392
PG 19
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 0OU0A
UT WOS:001452438900001
PM 40141039
OA gold
DA 2025-06-11
ER

PT J
AU Jin, YX
   Hu, HQ
   Zhang, JC
   Xin, XY
   Zhu, YT
   Zhang, HL
   Fan, RW
   Ye, Y
   Li, D
AF Jin, Yu-Xin
   Hu, Hang-Qi
   Zhang, Jia-Cheng
   Xin, Xi-Yan
   Zhu, Yu-Tian
   Zhang, Hao-Lin
   Fan, Rui-Wen
   Ye, Yang
   Li, Dong
TI Research status of polycystic ovary syndrome treatment: a mini review
   and a bibliometric analysis from 2010 to 2023
SO GYNECOLOGICAL ENDOCRINOLOGY
LA English
DT Review
DE Polycystic ovary syndrome; treatment; bibliometric analysis; VOSviewer;
   CiteSpace
ID CHINESE HERBAL MEDICINE; IN-VITRO FERTILIZATION; INSULIN-RESISTANCE;
   METABOLIC SYNDROME; OXIDATIVE STRESS; ANDROGEN EXCESS; WOMEN; RISK;
   PCOS; MANAGEMENT
AB BackgroundPolycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder in premenopausal women, often linked to abdominal obesity, insulin resistance, and metabolic issues. With its heterogeneous nature, PCOS treatment should be tailored to individual symptoms and patient preferences. This study examines collaboration networks among countries, institutions, authors, references, and journals related to PCOS treatment.MethodsWeb of Science data was analyzed using VOSviewer and CiteSpace for bibliometric visualization. Chinese and Western medicine treatments for PCOS were reviewed, emphasizing symptom-targeted solutions.ResultsData from 4682 records authored by 400 individuals from 515 institutes in 62 countries revealed China as the leading contributor. Notable authors include Monash University and Richard S. Legro. Common research themes include adipocytes, inflammation, insulin sensitivity, oxidative stress, and the gut microbiome. Tailoring treatment to individual needs is essential, focusing on hyperandrogenism, ovulation, and insulin resistance, with lifestyle counseling to address obesity.ConclusionThis bibliometric analysis provides valuable insights into the research status of PCOS treatment. China has made significant contributions, and complementary and alternative therapies, such as traditional Chinese medicine and acupuncture, have also shown beneficial effects recently. The research on inflammation, oxidative stress, and the gut microbiome may provide new targets and strategies for the treatment of PCOS. The recognition of the metabolic problems in PCOS patients facilitates the formulation of more personalized treatment plans to improve the prognosis of patients.
C1 [Jin, Yu-Xin; Hu, Hang-Qi; Zhang, Jia-Cheng; Xin, Xi-Yan; Zhu, Yu-Tian; Zhang, Hao-Lin; Fan, Rui-Wen; Ye, Yang; Li, Dong] Peking Univ Third Hosp, Dept Tradit Chinese Med, Beijing, Peoples R China.
C3 Peking University
RP Ye, Y; Li, D (corresponding author), Peking Univ Third Hosp, Dept Tradit Chinese Med, Beijing, Peoples R China.
EM yeyang89@126.com; lidong6512@sina.com
RI Zhu, Yutian/AGO-6789-2022; Zhang, Haolin/AAV-6440-2021; Zhang,
   Jiacheng/IZE-5121-2023; Ye, Yang/GXM-4085-2022
OI Ye, Yang/0000-0003-2314-4579
FU National Natural Science Foundation of China [82174151, 82074193];
   Capital's Funds for Health Improvement and Research [2024-2-4098,
   2020-2-40912, 2022-2-4097]; Cohort Construction Project of Peking
   University Third Hospital [BYSYDL2022013]
FX This study was funded by the National Natural Science Foundation of
   China [No. 82074193 and 82174151], Capital's Funds for Health
   Improvement and Research [No. 2024-2-4098, 2020-2-40912 and
   2022-2-4097], Cohort Construction Project of Peking University Third
   Hospital [No. BYSYDL2022013].
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NR 80
TC 0
Z9 0
U1 15
U2 42
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0951-3590
EI 1473-0766
J9 GYNECOL ENDOCRINOL
JI Gynecol. Endocrinol.
PD DEC 31
PY 2024
VL 40
IS 1
AR 2405098
DI 10.1080/09513590.2024.2405098
PG 13
WC Endocrinology & Metabolism; Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Obstetrics & Gynecology
GA G4C1E
UT WOS:001316128400001
PM 39297784
OA gold
DA 2025-06-11
ER

PT J
AU Wang, X
   He, B
AF Wang, Xia
   He, Ben
TI Endothelial dysfunction: molecular mechanisms and clinical implications
SO MEDCOMM
LA English
DT Review
DE cardiovascular disease; endothelial dysfunction; inflammation; nitric
   oxide; oxidative stress
ID CHRONIC KIDNEY-DISEASE; GLYCATION END-PRODUCTS; BLOOD-BRAIN-BARRIER;
   NITRIC-OXIDE; CARDIOVASCULAR-DISEASE; OXIDATIVE STRESS; VASCULAR
   INFLAMMATION; EXTRACELLULAR VESICLES; ADHESION MOLECULES; MEDITERRANEAN
   DIET
AB Cardiovascular disease (CVD) and its complications are a leading cause of death worldwide. Endothelial dysfunction plays a crucial role in the initiation and progression of CVD, serving as a pivotal factor in the pathogenesis of cardiovascular, metabolic, and other related diseases. The regulation of endothelial dysfunction is influenced by various risk factors and intricate signaling pathways, which vary depending on the specific disease context. Despite numerous research efforts aimed at elucidating the mechanisms underlying endothelial dysfunction, the precise molecular pathways involved remain incompletely understood. This review elucidates recent research findings on the pathophysiological mechanisms involved in endothelial dysfunction, including nitric oxide availability, oxidative stress, and inflammation-mediated pathways. We also discuss the impact of endothelial dysfunction on various pathological conditions, including atherosclerosis, heart failure, diabetes, hypertension, chronic kidney disease, and neurodegenerative diseases. Furthermore, we summarize the traditional and novel potential biomarkers of endothelial dysfunction as well as pharmacological and nonpharmacological therapeutic strategies for endothelial protection and treatment for CVD and related complications. Consequently, this review is to improve understanding of emerging biomarkers and therapeutic approaches aimed at reducing the risk of developing CVD and associated complications, as well as mitigating endothelial dysfunction.
   Endothelial dysfunction is commonly linked to various disease states resulting from an imbalance in the production of vasodilators and vasoconstrictors, among other factors. Human diseases associated with endothelial dysfunction include atherosclerosis, diabetes, metabolic syndrome, neurodegenerative diseases, chronic kidney disease, hypertension, heart failure, and stroke. image
C1 [Wang, Xia; He, Ben] Shanghai Jiao Tong Univ, Shanghai Chest Hosp, Sch Med, Dept Cardiol, Shanghai, Peoples R China.
C3 Shanghai Jiao Tong University
RP He, B (corresponding author), Shanghai Jiao Tong Univ, Shanghai Chest Hosp, Sch Med, Dept Cardiol, Shanghai, Peoples R China.
EM heben241@126.com
FU National Natural Science Foundation of China [82130012, 81830010];
   SINO-German Mobility Programme [M-0526]; Shanghai Arrhythmia Research
   Center Project [2022ZZ01008]; Clinical Research Plan of SHDC
   [SHDC2020CR1039B]; Clinical Research Plan of SHDC
FX National Natural Science Foundation of China, Grant/Award Numbers:
   82130012, 81830010; SINO-German Mobility Programme, Grant/Award Number:
   M-0526; Shanghai Arrhythmia Research Center Project, Grant/Award Number:
   2022ZZ01008; Clinical Research Plan of SHDC, Grant/Award Number:
   SHDC2020CR1039B
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NR 287
TC 30
Z9 30
U1 10
U2 19
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
EI 2688-2663
J9 MEDCOMM
JI MedComm
PD AUG
PY 2024
VL 5
IS 8
AR e651
DI 10.1002/mco2.651
PG 27
WC Medicine, Research & Experimental
WE Emerging Sources Citation Index (ESCI)
SC Research & Experimental Medicine
GA ZD7F8
UT WOS:001273415400001
PM 39040847
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Mayer, A
   Mizdrak, M
   Babic, M
   Mastelic, T
   Glavina, T
   Bozic, J
   Kurir, TT
AF Mayer, Ante
   Mizdrak, Maja
   Babic, Marija
   Mastelic, Tonci
   Glavina, Trpimir
   Bozic, Josko
   Kurir, inovic
TI Knowledge, Attitudes, and Screening for Obstructive Sleep Apnea and
   Diabetes Mellitus among War Veterans Seeking Treatment of Posttraumatic
   Stress Disorder
SO HEALTHCARE
LA English
DT Article
DE obstructive sleep apnea; STOP-Bang questionnaire; posttraumatic stress
   disorder; diabetes mellitus; prediabetes; war veterans; screening;
   cardiometabolic continuum; prevention; education
ID METABOLIC SYNDROME; CARDIOVASCULAR RISK; PREVALENCE; POPULATION;
   NIGHTMARES; MECHANISMS; SURVIVORS; SYMPTOMS; INSOMNIA; DISEASE
AB Posttraumatic stress disorder (PTSD) is one of the most common psychiatric disorders. However, we should not neglect the somatic aspects of PTSD. Associations with cardiovascular diseases (CVD) are particularly concerning because PTSD was associated with an even 53% higher risk for CVD. This study aimed to analyze the prevalence of several CVD risk factors, especially diabetes mellitus among PTSD patients divided into three groups according to obstructive sleep apnea (OSA) risk stratification (low, intermediate, and high). This cross-sectional study included one hundred male PTSD veterans. The mean age was 53 (40-67) years. The estimated OSA risk was 95% for the whole cohort, and 53% were in the high-risk group. Median HbA1c was 5.6 (4.6-10)%. The hemoglobin A1c (HbA1c) levels showed that 34 patients were in the prediabetes group, and 20 of them fulfilled the criteria for diabetes. However, only 13 of them were aware of their previous diagnosis of diabetes mellitus. In testing knowledge about diabetes, 62% and only 23% of patients knew the correct definition of HbA1c and level of fasting plasma glucose, respectively. Diabetic patients had insufficient knowledge about diabetic complications and treatment. A higher level of PTSD symptoms in veterans was associated with a higher prevalence of OSA. The results strongly support further research and education into early detection of CVD risk factors associated with PTSD.
C1 [Mayer, Ante] Hlth Ctr Split Dalmatia Cty, Split 21000, Croatia.
   [Mizdrak, Maja; Babic, Marija] Univ Hosp Split, Dept Nephrol & Hemodialysis, Split 21000, Croatia.
   [Mizdrak, Maja; Bozic, Josko; Kurir, inovic] Univ Split, Dept Pathophysiol, Sch Med, Split 21000, Croatia.
   [Mastelic, Tonci; Glavina, Trpimir] Univ Hosp Split, Dept Psychiat, Split 21000, Croatia.
   [Kurir, inovic] Univ Hosp Split, Dept Endocrinol Diabet & Metab Disorders, Split 21000, Croatia.
C3 University of Split; University of Split; University of Split;
   University of Split
RP Mizdrak, M (corresponding author), Univ Hosp Split, Dept Nephrol & Hemodialysis, Split 21000, Croatia.; Mizdrak, M (corresponding author), Univ Split, Dept Pathophysiol, Sch Med, Split 21000, Croatia.
EM mayerante@gmail.com; mmizdrak@mefst.hr; marija-babic92@hotmail.com;
   toncimastelic@hotmail.com; tglavina0@gmail.com; josko.bozic@mefst.hr;
   tticinov@mefst.hr
RI Babić Leko, Mirjana/C-3514-2018; Ticinovic Kurir, Tina/LZF-6766-2025;
   Bozic, Josko/E-1866-2017
OI Ticinovic Kurir, Tina/0009-0001-1179-2029; Bozic,
   Josko/0000-0003-1634-0635; Mizdrak, Maja/0000-0002-2112-004X
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NR 38
TC 3
Z9 3
U1 1
U2 3
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2227-9032
J9 HEALTHCARE-BASEL
JI Healthcare
PD DEC
PY 2021
VL 9
IS 12
AR 1698
DI 10.3390/healthcare9121698
PG 10
WC Health Care Sciences & Services; Health Policy & Services
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services
GA XY8BM
UT WOS:000737191100001
PM 34946424
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Hux, VJ
   Catov, JM
   Roberts, JM
AF Hux, Vanessa J.
   Catov, Janet M.
   Roberts, James M.
TI Allostatic Load in Women with a History of Low Birth Weight Infants: The
   National Health and Nutrition Examination Survey
SO JOURNAL OF WOMENS HEALTH
LA English
DT Article
ID CARDIOVASCULAR-DISEASE RISK; GESTATIONAL-AGE; PSYCHOSOCIAL STRESS;
   METABOLIC SYNDROME; PRETERM DELIVERY; UNITED-STATES; PREGNANCY;
   OUTCOMES; DISPARITIES; MACARTHUR
AB Background: The purpose of our study was to determine whether women of reproductive age with history of low birth weight (LBW) deliveries have higher allostatic load (AL), a measure of the cumulative toll of chronic stress, than those with normal-weight deliveries.
   Methods: We used data from women ages 17-35 who responded to the National Health and Nutrition Examination Survey (NHANES) reproductive-health questionnaire, 1999-2006. Women reported history of LBW infants and those who were preterm. We classified preterm-LBW and term-LBW as surrogates for preterm birth (PTB) and small for gestational age (SGA), respectively. Normal weight included those without LBW infant history. We utilized nine biomarkers measured in NHANES to determine AL and used linear regression to compare unadjusted and adjusted means.
   Results: We identified 877 women divided among SGA (2%), PTB (10%), and normal groups (88%). The SGA group had higher unadjusted and adjusted AL scores than did the normal group (2.82 +/- 0.35 vs. 1.92 +/- 0.07, p=0.011); women in the PTB group had higher AL scores than did the referent in adjusted analyses (2.58 +/- 0.21 vs. 1.92 +/- 0.07, p=0.001).
   Conclusions: Women with history of SGA or PTB had higher AL than did those with normal birth weight outcomes. This suggests a link between adverse pregnancy outcomes, chronic stress, and subclinical disease.
C1 [Hux, Vanessa J.] Vanderbilt Univ, Sch Med, Nashville, TN 37212 USA.
   [Hux, Vanessa J.; Catov, Janet M.; Roberts, James M.] Univ Pittsburgh, Magee Womens Res Inst, Dept Obstet Gynecol & Reprod Sci, Pittsburgh, PA USA.
   [Hux, Vanessa J.] Ohio State Univ, Coll Med, Dept Obstet & Gynecol, Columbus, OH 43210 USA.
   [Catov, Janet M.; Roberts, James M.] Univ Pittsburgh, Grad Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA USA.
   [Roberts, James M.] Univ Pittsburgh, Clin & Translat Res Inst, Pittsburgh, PA USA.
C3 Vanderbilt University; Pennsylvania Commonwealth System of Higher
   Education (PCSHE); University of Pittsburgh; Magee-Womens Research
   Institute; University System of Ohio; Ohio State University;
   Pennsylvania Commonwealth System of Higher Education (PCSHE); University
   of Pittsburgh; Pennsylvania Commonwealth System of Higher Education
   (PCSHE); University of Pittsburgh
RP Hux, VJ (corresponding author), Magee Womens Res Inst, 204 Craft Ave,A334, Pittsburgh, PA 15213 USA.
EM Vanessa.hux@osumc.edu
RI Roberts, James/AAI-3283-2020
FU Doris Duke Charitable Foundation; NIMH Research Education Grant [5R25
   MH054318]; Preeclampsia Program Project [NICHD P01 HD030377]
FX This work was supported by a grant from the Doris Duke Charitable
   Foundation to the University of Pittsburgh to fund Vanessa J. Hux as a
   Doris Duke Clinical Research Fellow; an NIMH Research Education Grant
   (5R25 MH054318) to Gretchen Haas, PhD; and the Preeclampsia Program
   Project (NICHD P01 HD030377). We also gratefully acknowledge Jia Xu for
   her guidance in NHANES statistical methods.
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NR 34
TC 43
Z9 56
U1 0
U2 11
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-9996
EI 1931-843X
J9 J WOMENS HEALTH
JI J. Womens Health
PD DEC 1
PY 2014
VL 23
IS 12
BP 1039
EP 1045
DI 10.1089/jwh.2013.4572
PG 7
WC Public, Environmental & Occupational Health; Medicine, General &
   Internal; Obstetrics & Gynecology; Women's Studies
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; General & Internal
   Medicine; Obstetrics & Gynecology; Women's Studies
GA AW1SM
UT WOS:000346070200009
PM 25495368
OA Green Published
DA 2025-06-11
ER

PT J
AU Tsarouhas, K
   Tsitsimpikou, C
   Haliassos, A
   Georgoulias, P
   Koutsioras, I
   Kouretas, D
   Kogias, J
   Liosis, I
   Rentoukas, E
   Kyriakides, Z
AF Tsarouhas, Konstantinos
   Tsitsimpikou, Christina
   Haliassos, Alexander
   Georgoulias, Panagiotis
   Koutsioras, Ioannis
   Kouretas, Demetrios
   Kogias, John
   Liosis, Ioannis
   Rentoukas, Elias
   Kyriakides, Zenon
TI Study of Insulin Resistance, TNF-α, Total Antioxidant Capacity and Lipid
   Profile in Patients with Chronic Heart Failure under Exercise
SO IN VIVO
LA English
DT Article
DE TNF-alpha; total antioxidant capacity; lipids; insulin resistance;
   chronic heart failure
ID DENSITY-LIPOPROTEIN CHOLESTEROL; XANTHINE-OXIDASE INHIBITION; OXIDATIVE
   STRESS; PHYSICAL-EXERCISE; RISK; PERFORMANCE; HYPERURICEMIA; SEDENTARY;
   DISEASE; MARKERS
AB Gluco-metabolic syndrome, oxidative stress and inflammation are common in chronic heart failure (CHF). Exercise training programmes are known to improve oxidative status, insulin sensitivity and endothelial function. In this study, the effects of walking on improving lipid and glucose metabolism in CHF patients, under statin treatment, were investigated. Fasting glucose, serum insulin, tumor necrosis factor-alpha (TNF-alpha), total antioxidant capacity (TAC), uric acid (UA), total cholesterol, triglycerides, high-density lipoproteins (HDL), direct low-density lipoproteins (LDL-dir), apolipoprotein-B, apolipoprotein-A1, and lipoprotein-a (Lp(a)) were monitored. Insulin resistance was depicted by fasting insulin resistance index (FIRI >= 2.94 +/- 1.41). HDL significantly increased with walking and was positively correlated with the non-significant triglyceride decrease and significant Lp(a) decrease. Significant correlations were found in all CHF patients at baseline between FIRI and New York Heart Association (NYHA) functional class, ejection fraction, HDL, triglycerides and TNF-alpha. All non-diabetic CHF patients were characterized by insulin resistance. Serum insulin and fasting glucose significantly decreased with walking, while decrease in FIRI was positively associated with patients' adherence to the walking program. Elevated uric acid and TNF-alpha levels also significantly decreased. In conclusion, the present study demonstrated that moderate, unsupervised, everyday physical activity was able to ameliorate the lipid and glycemic profile of CHF patients, with simultaneous attenuation of inflammation and oxidative stress.
C1 [Tsarouhas, Konstantinos; Kogias, John] Gen Hosp Karditsa, Div Cardiol, Terma Tavropou 43100, Karditsa, Greece.
   [Tsitsimpikou, Christina] Gen Chem State Lab Greece, Athens, Greece.
   [Haliassos, Alexander] ESEAP & Diamed SA, Athens, Greece.
   [Georgoulias, Panagiotis] Univ Thessaly, Sch Med, Dept Nucl Med, Mezourlo Area, Larisa, Greece.
   [Koutsioras, Ioannis; Kouretas, Demetrios] Univ Thessaly, Dept Biochem & Biotechnol, Larisa, Greece.
   [Koutsioras, Ioannis] Red Cross Gen Hosp, Dept Biochem & Microbiol, Athens, Greece.
   [Kyriakides, Zenon] Red Cross Gen Hosp, Cardiol Dept 2, Athens, Greece.
   [Rentoukas, Elias] Amalia Fleming Gen Hosp, Cardiol Dept 2, Athens, Greece.
C3 University of Thessaly; University of Thessaly
RP Tsarouhas, K (corresponding author), Gen Hosp Karditsa, Div Cardiol, Terma Tavropou 43100, Karditsa, Greece.
EM ktsarouhas14@yahoo.gr
RI Haliassos, Alexander/GYJ-3828-2022; KOURETAS, DEMETRIOS/ABE-8519-2020;
   Tsarouhas, Konstantinos/H-5793-2019
OI Tsarouhas, Konstantinos/0000-0003-2651-3579; Georgoulias,
   Panagiotis/0000-0002-6493-705X
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NR 43
TC 21
Z9 27
U1 0
U2 6
PU INT INST ANTICANCER RESEARCH
PI ATHENS
PA EDITORIAL OFFICE 1ST KM KAPANDRITIOU-KALAMOU RD KAPANDRITI, PO BOX 22,
   ATHENS 19014, GREECE
SN 0258-851X
EI 1791-7549
J9 IN VIVO
JI In Vivo
PD NOV-DEC
PY 2011
VL 25
IS 6
BP 1031
EP 1037
PG 7
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 838QH
UT WOS:000296306800022
PM 22021702
DA 2025-06-11
ER

PT J
AU Dominguez, LJ
   Veronese, N
   Guerrero-Romero, F
   Barbagallo, M
AF Dominguez, Ligia J.
   Veronese, Nicola
   Guerrero-Romero, Fernando
   Barbagallo, Mario
TI Magnesium in Infectious Diseases in Older People
SO NUTRIENTS
LA English
DT Review
DE magnesium; oxidative stress; inflammation; aging; infectious diseases;
   vitamin D; COVID-19
ID C-REACTIVE PROTEIN; VITAMIN-D RESISTANCE; INFLAMMATORY RESPONSE;
   OXIDATIVE STRESS; DIETARY MAGNESIUM; RAT-HEART; ENDOTHELIAL DYSFUNCTION;
   COVID-19 MORTALITY; METABOLIC SYNDROME; MG2+ HOMEOSTASIS
AB Reduced magnesium (Mg) intake is a frequent cause of deficiency with age together with reduced absorption, renal wasting, and polypharmacotherapy. Chronic Mg deficiency may result in increased oxidative stress and low-grade inflammation, which may be linked to several age-related diseases, including higher predisposition to infectious diseases. Mg might play a role in the immune response being a cofactor for immunoglobulin synthesis and other processes strictly associated with the function of T and B cells. Mg is necessary for the biosynthesis, transport, and activation of vitamin D, another key factor in the pathogenesis of infectious diseases. The regulation of cytosolic free Mg in immune cells involves Mg transport systems, such as the melastatin-like transient receptor potential 7 channel, the solute carrier family, and the magnesium transporter 1 (MAGT1). The functional importance of Mg transport in immunity was unknown until the description of the primary immunodeficiency XMEN (X-linked immunodeficiency with Mg defect, Epstein-Barr virus infection, and neoplasia) due to a genetic deficiency of MAGT1 characterized by chronic Epstein-Barr virus infection. This and other research reporting associations of Mg deficit with viral and bacterial infections indicate a possible role of Mg deficit in the recent coronavirus disease 2019 (COVID-19) and its complications. In this review, we will discuss the importance of Mg for the immune system and for infectious diseases, including the recent pandemic of COVID-19.
C1 [Dominguez, Ligia J.; Veronese, Nicola; Barbagallo, Mario] Univ Palermo, Dept Internal Med & Geriatr, Geriatr Unit, I-90100 Palermo, Italy.
   [Guerrero-Romero, Fernando] Mexican Inst Social Secur IMSS, Biomed Res Unit, Durango 34067, Mexico.
C3 University of Palermo; Instituto Mexicano del Seguro Social
RP Veronese, N (corresponding author), Univ Palermo, Dept Internal Med & Geriatr, Geriatr Unit, I-90100 Palermo, Italy.
EM ligia.dominguez@unipa.it; nicola.veronese@unipa.it;
   guerrero.romero@gmail.com; mario.barbagallo@unipa.it
RI Veronese, Nicola/K-4343-2018; BARBAGALLO, MARIO/K-4794-2017
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NR 186
TC 58
Z9 60
U1 0
U2 16
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JAN
PY 2021
VL 13
IS 1
AR 180
DI 10.3390/nu13010180
PG 23
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nutrition & Dietetics
GA PW4VR
UT WOS:000610669100001
PM 33435521
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Sieminska, E
   Sobczak, P
   Skibinska, N
   Sikora, J
AF Sieminska, Emilia
   Sobczak, Przemyslaw
   Skibinska, Natalia
   Sikora, Joanna
TI The differential role of uric acid - The purpose or cause of
   cardiovascular diseases?
SO MEDICAL HYPOTHESES
LA English
DT Article
DE Uric acid; Cardiovascular disease; Prooxidant; Antioxidant;
   Epidemiological studies; Uric acid-lowering therapy
ID CORONARY-HEART-DISEASE; ALL-CAUSE MORTALITY; C-REACTIVE PROTEIN;
   XANTHINE-OXIDASE INHIBITION; ACUTE MYOCARDIAL-INFARCTION; VASCULAR
   OXIDATIVE STRESS; HIGH-DOSE ALLOPURINOL; RISK-FACTOR; INDEPENDENT
   PREDICTOR; ENDOTHELIAL FUNCTION
AB For 40 years many studies have been conducted to verify the connection between serum uric acid concentration and cardiovascular diseases, such as myocardial infarction. Unfortunately, it remains unclear which form of uric acid - prooxidant or antioxidant - could be a predictive marker of cardiovascular disease, especially in patients after myocardial infarction. It is well-known that uric acid is an organic compound and the water-soluble final product of purine catabolism, which is catalysed by xanthine oxidoreductase and excreted by kidneys. An increased concentration of UA in human plasma leads to diseases like tumours, renal disorders, atherosclerosis, hypertension, diabetes, metabolic syndrome, polycythaemia vera, haemolytic anaemias, ischemia, oxidative stress, and rare genetic disorders connected with UA degradation. Epidemiological studies have shown that UA might be a marker of oxidative stress, progression of inflammation, or renal disease. A fortiori, it is possible that could also be a predictor for short/long-term survival of patients with CVD. Evidence provided by multiple studies is controversial and mutually exclusive. Among 71 studies the most of them found an independent association between SUA and CVD risk. Some of those studies confirm that CVD risk is higher in women who had elevated SUA levels. On the other hand, many studies reached the opposite conclusion and did not find any relationship between SUA and CVD mortality and morbidity.
C1 [Sieminska, Emilia; Sikora, Joanna] Coll Med Bydgoszcz, Dept Transplantol & Gen Surg, PL-85092 Bydgoszcz, Poland.
   [Sobczak, Przemyslaw; Skibinska, Natalia] Coll Med Bydgoszcz, Dept Cardiol & Internal Med, PL-85092 Bydgoszcz, Poland.
C3 Nicolaus Copernicus University; Nicolaus Copernicus University
RP Sieminska, E (corresponding author), Coll Med Bydgoszcz, Dept Transplantol & Gen Surg, PL-85092 Bydgoszcz, Poland.
EM e.m.sieminska@gmail.com
RI Sobczak, Przemysław/AAI-7009-2021; Sikora, Joanna/P-1826-2015
OI Sikora, Joanna/0000-0003-1095-3844
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NR 145
TC 15
Z9 16
U1 0
U2 8
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0306-9877
EI 1532-2777
J9 MED HYPOTHESES
JI Med. Hypotheses
PD SEP
PY 2020
VL 142
AR 109791
DI 10.1016/j.mehy.2020.109791
PG 11
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA NI2OU
UT WOS:000565195600029
PM 32434129
DA 2025-06-11
ER

PT J
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   Murphy, E. Angela
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SO PLOS ONE
LA English
DT Article
ID ENDOPLASMIC-RETICULUM STRESS; FATTY-LIVER-DISEASE; BODY-MASS INDEX;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; SATURATED FAT; C57BL/6J MICE;
   RATS; INFLAMMATION; CANCER
AB The purpose of this study was to examine the effect of a 40% high-fat diet (HFD) supplemented with a dietary attainable level of quercetin (0.02%) on body composition, adipose tissue (AT) inflammation, Non-Alcoholic Fatty-Liver Disease (NAFLD), and metabolic outcomes. Diets were administered for 16 weeks to C57BL/6J mice (n = 10/group) beginning at 4 weeks of age. Body composition and fasting blood glucose, insulin, and total cholesterol concentrations were examined intermittently. AT and liver mRNA expression (RT-PCR) of inflammatory mediators (F4/80, CD206 (AT only), CD11c (AT only) TLR-2 (AT only), TLR-4 (AT only), MCP-1, TNF-alpha, IL-6 (AT only), and IL-10 (AT only)) were measured along with activation of NF kappa B-p65, and JNK (western blot). Hepatic lipid accumulation, gene expression (RT-PCR) of hepatic metabolic markers (ACAC1, SREBP-1, PPAR-gamma), protein content of Endoplasmic Reticulum (ER) Stress markers (BiP, phosphorylated and total EIF2 alpha, phosphorylated and total IRE1 alpha, CHOP), and hepatic oxidative capacity were assessed (western blot). Quercetin administration had no effect at mitigating increases in visceral AT, AT inflammation, hepatic steatosis, ER Stress, decrements in hepatic oxidative capacity, or the development of insulin resistance and hypercholesterolemia. In conclusion, 0.02% quercetin supplementation is not an effective therapy for attenuating HFD-induced obesity development. It is likely that a higher dose of quercetin supplementation is needed to elicit favorable outcomes in obesity.
C1 [Enos, Reilly T.; Velazquez, Kandy T.; Carson, Meredith S.; McClellan, Jamie L.; Nagarkatti, Prakash; Nagarkatti, Mitzi; Murphy, E. Angela] Univ South Carolina, Sch Med, Dept Pathol Microbiol & Immunol, Columbia, SC 29208 USA.
   [Davis, J. Mark] Univ South Carolina, Dept Exercise Sci, Columbia, SC 29208 USA.
C3 University of South Carolina System; University of South Carolina
   Columbia; University of South Carolina System; University of South
   Carolina Columbia
RP Murphy, EA (corresponding author), Univ South Carolina, Sch Med, Dept Pathol Microbiol & Immunol, Columbia, SC 29208 USA.
EM Angela.Murphy@uscmed.sc.edu
RI davis, mark/AAD-9575-2021; Enos, Reilly/AFO-4814-2022
OI Nagarkatti, Prakash/0000-0003-2663-0759
FU NIH/NCI [R21CA175636]; NIH/NCCIH [K01AT007824]
FX This work was supported by grants R21CA175636 (NIH/NCI) and K01AT007824
   (NIH/NCCIH) to EAM. The funders had no role in study design, data
   collection, and analysis, decision to publish, or preparation of the
   manuscript.
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NR 47
TC 22
Z9 26
U1 1
U2 6
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD DEC 13
PY 2016
VL 11
IS 12
AR e0167979
DI 10.1371/journal.pone.0167979
PG 21
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA EI8JY
UT WOS:000392753900029
PM 27959936
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Cakmak, E
   Yardim-Akaydin, S
   Caliskan-Can, E
   Firat, H
   Ardic, S
AF Cakmak, E.
   Yardim-Akaydin, S.
   Caliskan-Can, E.
   Firat, H.
   Ardic, S.
TI SERUM NITROTYROSINE AND NITRIC OXIDE MEASUREMENTS IN OBSTRUCTIVE SLEEP
   APNEA SYNDROME
SO OXIDATION COMMUNICATIONS
LA English
DT Article
DE nitrotyrosine; nitric oxide; obstructive sleep apnea syndrome; metabolic
   syndrome
ID IMPROVES ENDOTHELIAL FUNCTION; APOLIPOPROTEIN-A-I; OXIDATIVE STRESS;
   PEROXYNITRITE; PLASMA; MECHANISMS; NITRATION; OVERWEIGHT; KINETICS
AB The recurrent episodes of hypoxia-reoxygenation (H/R) appear to be partly responsible for the increased oxidative stress in obstructive sleep apnea syndrome (OSAS). Peroxynitrite (ONOO-) is a product of the reaction of superoxide radical (O-2(-)) and nitric oxide (NO) and affects mitochondrial function and leads to cell death through oxidation and nitration reactions. The attacks of ONOO- on the proteins result in the nitration of tyrosine and lead to the formation of 3-nitrotyrosine (3-NT). The purpose of this study was to investigate the levels of total NO and 3-NT in OSAS. 3-NT was detected by competitive Elisa method and total NO was detected by modified Griess method in serum samples of patients with OSAS (n = 109) and healthy controls (n = 24). Compared to healthy controls, there was slightly increase in 3-nitrotyrosine levels and decreases in total NO levels in patients (p > 0.05). We observed effects of age, gender, and smoking on total NO. In OSAS group, statistically significant correlations were observed between 3-NT and triglyceride values in positive manner (r = 0.435, p = 0.0001) and between 3-NT and HDL levels in negative manner (r = 0,238, p = 0.033). Considering that proteins are much more resistant to oxidative damage than other biomolecules, even slightly elevated 3-NT values due to oxidative stress in patients with OSAS could be indicator of protein damage.
C1 [Cakmak, E.; Yardim-Akaydin, S.; Caliskan-Can, E.] Gazi Univ, Fac Pharm, Dept Biochem, TR-06330 Ankara, Turkey.
   [Firat, H.; Ardic, S.] Diskapi Yildirim Beyazit Training & Res Hosp, Minist Hlth, Dept Chest Dis, TR-06110 Ankara, Turkey.
C3 Gazi University; Ministry of Health - Turkey; Diskapi Yildirim Beyazit
   Training & Research Hospital
RP Yardim-Akaydin, S (corresponding author), Gazi Univ, Fac Pharm, Dept Biochem, TR-06330 Ankara, Turkey.
EM sevgiy@gazi.edu.tr
RI AKAYDIN, Sevgi/AHB-3268-2022; FIRAT, Hikmet/E-3047-2017
OI FIRAT, Hikmet/0000-0003-2594-4887
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NR 44
TC 3
Z9 3
U1 0
U2 8
PU SCIBULCOM LTD
PI SOFIA
PA PO BOX 249, 1113 SOFIA, BULGARIA
SN 0209-4541
J9 OXID COMMUN
JI Oxid. Commun.
PY 2015
VL 38
IS 4A
SI SI
BP 2064
EP 2075
PG 12
WC Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry
GA DI1IR
UT WOS:000373250300009
DA 2025-06-11
ER

PT J
AU Chatziharalambous, D
   Papagianni, O
   Potsaki, P
   Almpounioti, K
   Koutelidakis, AE
AF Chatziharalambous, Despina
   Papagianni, Olga
   Potsaki, Panagiota
   Almpounioti, Kalliopi
   Koutelidakis, Antonios E.
TI Effect of Acute Consumption of Crackers Enriched with Grape Seed Flour
   or Barley Flour with Added β-Glucan on Biomarkers of Postprandial
   Glycemia, Lipidemia, and Oxidative Stress: A Crossover Study
SO APPLIED SCIENCES-BASEL
LA English
DT Article
DE grape seed flour; barley flour; crackers; glycemia; oxidative stress;
   lipidemia
ID DIETARY FIBER; QUALITY CHARACTERISTICS; CONSUMER ACCEPTANCE; INSULIN
   RESPONSES; GLUCOSE RESPONSE; LDL-CHOLESTEROL; PLASMA-GLUCOSE; RED WINE;
   POLYPHENOLS; HEALTH
AB Background: Grape seed polyphenol bioactivity is linked to reduced risk of metabolic syndrome, type 2 diabetes, obesity, and coronary heart disease development. Furthermore, regular consumption of beta-glucan is associated with decreased lipidemic and glycemic profiles. The aim was to investigate the acute effect of crackers enriched with either 10% grape seed flour or 40% barley flour with added beta-glucan along with a high-fat and high-carbohydrate meal on biomarkers of postprandial glycemia, lipidemia, and oxidative stress. Methods: In a randomized, three-arm crossover design study, 12 healthy subjects were assigned to consume breakfast consisting of bread, butter, and 250 mL water along with crackers containing either (a) wheat flour, (b) 10% grape seed flour, or (c) 40% barley flour enriched with beta-glucan. Blood samples were drawn immediately before and 30, 90, and 180 min after the meal. Total antioxidant capacity was measured in plasma with the FRAP method. Total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglycerides, glucose, and uric acid were measured in serum. Results: Tested markers did not differ between the intervention groups at baseline, 30, 90, and 180 min (p >= 0.05) post-prandially. Conclusions: Enriched cracker consumption did not significantly affect the selected markers at the postprandial state, although better serum glucose and lipid levels, similar to baseline values, were maintained.
C1 [Chatziharalambous, Despina; Papagianni, Olga; Potsaki, Panagiota; Almpounioti, Kalliopi; Koutelidakis, Antonios E.] Univ Aegean, Unit Human Nutr, Lab Nutr & Publ Hlth, Dept Food Sci & Nutr, Leoforos Dimokratias 66, Myrina 81400, Lemnos, Greece.
RP Koutelidakis, AE (corresponding author), Univ Aegean, Unit Human Nutr, Lab Nutr & Publ Hlth, Dept Food Sci & Nutr, Leoforos Dimokratias 66, Myrina 81400, Lemnos, Greece.
EM fnsd21007@fns.aegean.gr; olga3_pap@yahoo.gr; potsaki.giota@gmail.com;
   k.almpounioti@gmail.com; akoutel@aegean.gr
RI Papagianni, Olga/KIE-3020-2024
FU European Regional Development Fund of the European Union and Greek
   national funds
FX We would like to thank all the volunteers who participated in this
   study.
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NR 70
TC 1
Z9 1
U1 3
U2 6
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3417
J9 APPL SCI-BASEL
JI Appl. Sci.-Basel
PD JUN
PY 2024
VL 14
IS 11
AR 4591
DI 10.3390/app14114591
PG 18
WC Chemistry, Multidisciplinary; Engineering, Multidisciplinary; Materials
   Science, Multidisciplinary; Physics, Applied
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Engineering; Materials Science; Physics
GA UB8X0
UT WOS:001245703800001
OA gold
DA 2025-06-11
ER

PT J
AU Syed, I
   Szulc, ZM
   Ogretmen, B
   Kowluru, A
AF Syed, Ismail
   Szulc, Zdzislaw M.
   Ogretmen, Besim
   Kowluru, Anjaneyulu
TI L-threo-C6-pyridinium-ceramide Bromide, a Novel
   Cationic Ceramide, Induces NADPH Oxidase Activation, Mitochondrial
   Dysfunction and Loss in Cell Viability in INS 832/13 β-cells
SO CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
LA English
DT Article
DE Ceramide; Cationic ceramide; NADPH oxidase; Islet beta-cell;
   Mitochondrial dysfunction
ID RAT PANCREATIC-ISLETS; OXIDATIVE STRESS; METABOLIC SYNDROME; SIGNALING
   PATHWAY; NAD(P)H OXIDASE; APOPTOSIS; GLUCOSE; RAC1; LINE
AB Background: Emerging evidence indicates that exposure of isolated pancreatic beta-cells to elevated glucose [glucotoxicity] or saturated fatty acids such as palmitate [lipotoxicity] or both [glucolipotoxicity] results in excessive intracellular oxidative stress mediated by phagocyte-like NADPH oxidase [Nox2]. Pharmacological evidence also implicates the intracellular generation of ceramide [CER] as one of the mediators of palmitate-induced cytotoxicity of the islet beta-cell. Herein, we investigated the effects of L-threo-C6-pyridinium-ceramide bromide, a novel water soluble cationic ceramide [Ws-CER], on mitochondrial function and cell viability in insulin-secreting INS 832/13 cells. Methods: Ws-CER, was synthesized as we reported earlier. Rac1 activation was quantitated by pull-down assay. Mitochondrial membrane potential was quantitated by JC-1 staining. Nox2 subunit expression and caspase-3 activity were determined by Western blotting. Results: Our findings suggested a marked increase in the Nox2 activation [i.e., ROS generation and subunit expression and activation] in cells exposed to Ws-CER. We also noticed a significant reduction in mitochondrial membrane potential, increased in caspase-3 activity and associated loss in cell viability in Ws-CER-treated cells. Conclusion: Based on these data we conclude that ceramide-induced Nox2-mediated oxidative stress couples mitochondrial dysfunction to loss in cell viability in the pancreatic beta-cell. Copyright (C) 2012 S. Karger AG, Basel
C1 [Syed, Ismail; Kowluru, Anjaneyulu] Wayne State Univ, John D Dingell VA Med Ctr, Res Serv, Beta Cell Biochem Lab, Detroit, MI 48201 USA.
   [Szulc, Zdzislaw M.; Ogretmen, Besim] Med Univ S Carolina, Dept Biochem, Charleston, SC 29425 USA.
   [Szulc, Zdzislaw M.; Ogretmen, Besim] Med Univ S Carolina, Dept Mol Biol, Charleston, SC 29425 USA.
   [Syed, Ismail] Beth Israel Deaconess Med Ctr, Dept Med, Div Endocrinol Diabet & Metab, Boston, MA 02215 USA.
   [Syed, Ismail] Harvard Univ, Sch Med, Boston, MA USA.
C3 Wayne State University; Medical University of South Carolina; Medical
   University of South Carolina; Harvard University; Harvard University
   Medical Affiliates; Beth Israel Deaconess Medical Center; Harvard
   University; Harvard Medical School
RP Kowluru, A (corresponding author), Wayne State Univ, John D Dingell VA Med Ctr, Res Serv, Beta Cell Biochem Lab, B4237,4646 John R, Detroit, MI 48201 USA.
EM akowluru@med.wayne.edu
OI Kowluru, Anjaneyulu/0000-0003-1700-0077; SYED,
   ISMAIL/0000-0002-1941-5957
FU Department of Veterans Affairs, Veterans Health Administration, Office
   of Research and Development [Biomedical Laboratory Research and
   Development] [1BX000469]; NIH [DK74921, CA97165]; Department of VA; NCI
   [IP01CA097132, P30 CA 138313]; NIH/NCRR SC COBRE [P20 RR017677]; NIH of
   the National Center for Research Resources [C06 RR018823]
FX This research was supported in part by a Merit Review award [to AK;
   1BX000469] from the Department of Veterans Affairs, Veterans Health
   Administration, Office of Research and Development [Biomedical
   Laboratory Research and Development], and by the NIH [DK74921 to AK, and
   CA97165 to BO]. AK is also the recipient of a Senior Research Career
   Scientist Award from the Department of VA. The authors would like to
   thank Prof. Chris Newgard for INS 832/13 cells. The synthesis of Ws-CER
   was performed by Lipidomics Shared Resource (Medical University of South
   Carolina), supported by NCI Grants: IP01CA097132 and P30 CA 138313 and
   NIH/NCRR SC COBRE Grant P20 RR017677. Laboratory space for Lipidomics
   Shared Resource was supported by the NIH, Grant C06 RR018823 from the
   Extramural Research Facilities Program of the National Center for
   Research Resources.
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NR 21
TC 12
Z9 13
U1 0
U2 3
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1015-8987
J9 CELL PHYSIOL BIOCHEM
JI Cell. Physiol. Biochem.
PY 2012
VL 30
IS 4
BP 1051
EP 1058
DI 10.1159/000341481
PG 8
WC Cell Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Physiology
GA 022RO
UT WOS:000309979900022
PM 23052231
OA gold
DA 2025-06-11
ER

PT J
AU Hayden, MR
   Tyagi, SC
AF Hayden, Melvin R.
   Tyagi, Suresh C.
TI Is type 2 diabetes mellitus a vascular disease (atheroscleropathy) with
   hyperglycemia a late manifestation? The role of NOS, NO, and redox
   stress
SO CARDIOVASCULAR DIABETOLOGY
LA English
DT Article
ID NITRIC-OXIDE SYNTHASE; CORONARY-ARTERY-DISEASE; INSULIN-RESISTANCE;
   FOLIC-ACID; CARDIOVASCULAR-DISEASE; GLU298ASP POLYMORPHISM; PLASMA
   HOMOCYSTEINE; COMMON VARIANT; ASSOCIATION; GENE
AB Background: Cardiovascular disease accounts for at least 85 percent of deaths for those patients with type 2 diabetes mellitus (T2DM). Additionally, 75 percent of these deaths are due to ischemic heart disease.
   Hypothesis: Is type 2 diabetes mellitus a vascular disease (atheroscleropathy) with hyperglycemia a late manifestation? The role of NOS, NO, and redox stress.
   Testing of the hypothesis: The vulnerable three arms of the eNOS reaction responsible for the generation of eNO is discussed in relation to the hypothesis: (1). The L-arginine substrate. (2). The eNOS enzyme. (3). The BH4 cofactor.
   Implications of the hypothesis: If we view T2DM as a vascular disease initially with a later manifestation of hyperglycemia, we may be able to better understand and modify the multiple toxicities associated with insulin resistance, metabolic syndrome, prediabetes, overt T2DM, and accelerated atherosclerosis (atheroscleropathy). The importance of endothelial nitric oxide synthase, endothelial nitric oxide, tetrahydrobiopterin (BH4), L-arginine, and redox stress are discussed in relation to endothelial cell dysfunction and the development and progression of atheroscleropathy and T2DM. In addition to the standard therapies to restore endothelial cell dysfunction and stabilization of vulnerable atherosclerotic plaques, this article will discuss the importance of folic acid (5MTHF) supplementation in this complex devastating disease process.
   Atheroscleropathy and hyperglycemia could be early and late manifestations, respectively, in the natural progressive history of T2DM.
C1 [Hayden, Melvin R.] Univ Missouri Columbia, Dept Family & Community Med, Camdenton, MO 65020 USA.
   [Tyagi, Suresh C.] Univ Mississippi, Med Ctr, Dept Physiol & Biophys, Jackson, MS 39216 USA.
C3 University of Missouri System; University of Missouri Columbia;
   University of Mississippi Medical Center; University of Mississippi
RP Hayden, MR (corresponding author), Univ Missouri Columbia, Dept Family & Community Med, POB 1140,Lk Rd 5-87, Camdenton, MO 65020 USA.
EM mrh29@usmo.com; styagi@physiology.umsmed.edu
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NR 46
TC 69
Z9 82
U1 0
U2 6
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1475-2840
J9 CARDIOVASC DIABETOL
JI Cardiovasc. Diabetol.
PY 2003
VL 2
AR 2
DI 10.1186/1475-2840-2-2
PG 10
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism
GA V23DB
UT WOS:000208322400002
PM 12628022
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Putsa, B
   Jalayondeja, W
   Mekhora, K
   Bhuanantanondh, P
   Jalayondeja, C
AF Putsa, Bukhari
   Jalayondeja, Wattana
   Mekhora, Keerin
   Bhuanantanondh, Petcharatana
   Jalayondeja, Chutima
TI Factors associated with reduced risk of musculoskeletal disorders among
   office workers: a cross-sectional study 2017 to 2020
SO BMC PUBLIC HEALTH
LA English
DT Article
DE Musculoskeletal disorders; Physical activity; Physical fitness;
   Sedentary behavior; Sitting; Stress; Office workers
ID PHYSICAL-ACTIVITY; LOW-BACK; MUSCLE ENDURANCE; NECK PAIN; PREVALENCE;
   DISCOMFORT; STRENGTH; PERFORMANCE; SYMPTOMS; FITNESS
AB Background Prolonged sitting at work should be avoided to reduce the risks of either noncommunicable diseases (NCDs) or musculoskeletal disorders (MSDs) among office workers. A short duration of breaks in sitting every hour can reduce cardiometabolic risk factors contributing to NCDs. However, the recommendation for a break from sitting at work to reduce the risks of MSDs has not been identified. Therefore, this study aimed to determine whether breaking by changing position at work, physical activity, physical fitness, stress and sleep were associated with MSDs among office workers. Methods A cross-sectional study was conducted from 2017 to 2020. Participants aged 20-59 years and using a computer at work >= 4 days/week were recruited. Data were collected using an online self-reporting questionnaire for computer users and 5 domains of physical fitness tests. Odds ratio (OR) with 95% confidence interval (CI) and multivariate logistic regression were used for statistical analysis. Results Prevalence of MSDs was 37.9% (n = 207/545) and the most area of complaint were the neck, shoulders and back. A nonsignificant association between physical fitness and MSDs among office workers was obtained. After adjusting for age, sex, body mass index, and comorbidity, moderate-to-vigorous intensity physical activity (MVPA) >= 150 min/week and sitting at work >= 4 h/day were MSDs risk factors (OR = 1.57, 95%CI = 1.04-2.37). Frequently changing positions from sitting to standing or walking at work every hour could reduce the risks of MSDs by more than 30%. The risks of MSDs increased among office workers who commuted by staff shuttle bus and personal car and had high to severe stress and slept < 6 h/day (1.6 to 2.4 times). Conclusion Our findings indicated MVPA and prolonged sitting were MSD risk factors. We recommend office workers change position from sitting to standing or walking during work every hour and sleep >= 6 h/day to reduce risks of MSDs.
C1 [Putsa, Bukhari; Jalayondeja, Wattana; Mekhora, Keerin; Bhuanantanondh, Petcharatana; Jalayondeja, Chutima] Mahidol Univ, Fac Phys Therapy, Salaya, Nakhon Pathom, Thailand.
C3 Mahidol University
RP Jalayondeja, C (corresponding author), Mahidol Univ, Fac Phys Therapy, Salaya, Nakhon Pathom, Thailand.
EM chutima.jal@mahidol.ac.th
FU National Research Council of Thailand (NRCT) [PHD/0065/2561]; Thai
   Health Promotion Foundation (ThaiHealth) [2016_01, 2018_02]
FX This study was supported by the National Research Council of Thailand
   (NRCT) under the Royal Golden Jubilee PhD (RGJ.PHD and grant No.
   PHD/0065/2561.) and Thai Health Promotion Foundation (ThaiHealth and
   grant No 2016_01 and 2018_02).
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NR 53
TC 27
Z9 28
U1 1
U2 23
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2458
J9 BMC PUBLIC HEALTH
JI BMC Public Health
PD AUG 6
PY 2022
VL 22
IS 1
AR 1503
DI 10.1186/s12889-022-13940-0
PG 11
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA 3O1ME
UT WOS:000836603200002
PM 35932005
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Kuchay, MS
   Choudhary, NS
   Ramos-Molina, B
AF Kuchay, Mohammad Shafi
   Choudhary, Narendra Singh
   Ramos-Molina, Bruno
TI Pathophysiological underpinnings of metabolic dysfunction-associated
   steatotic liver disease
SO AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
LA English
DT Review
DE advanced fibrosis; hepatic stellate cell activation; immune
   dysregulation; lipotoxicity; metabolic dysfunction-associated steatotic
   liver disease
ID HIGH-FAT DIET; INFLAMMATORY EXTRACELLULAR VESICLES;
   ENDOPLASMIC-RETICULUM STRESS; INDUCED INSULIN-RESISTANCE; HEPATIC
   STELLATE CELLS; NECROSIS-FACTOR-ALPHA; NONALCOHOLIC STEATOHEPATITIS;
   NLRP3 INFLAMMASOME; OXIDATIVE STRESS; NUCLEAR RECEPTOR
AB Metabolic dysfunction-associated steatotic liver disease (MASLD) is emerging as the leading cause of chronic liver disease worldwide, reflecting the global epidemics of obesity, metabolic syndrome, and type 2 diabetes. Beyond its strong association with excess adiposity, MASLD encompasses a heterogeneous population that includes individuals with normal body weight ("lean MASLD") highlighting the complexity of its pathogenesis. This disease results from a complex interplay between genetic susceptibility, epigenetic modifications, and environmental factors, which converge to disrupt metabolic homeostasis. Adipose tissue dysfunction and insulin resistance trigger an overflow of lipids to the liver, leading to mitochondrial dysfunction, oxidative stress, and hepatocellular injury. These processes promote hepatic inflammation and fibrogenesis, driven by cross talk among hepatocytes, immune cells, and hepatic stellate cells, with key contributions from gut-liver axis perturbations. Recent advances have unraveled pivotal molecular pathways, such as transforming growth factor-beta signaling, Notch-induced osteopontin, and sphingosine kinase 1-mediated responses, that orchestrate fibrogenic activation. Understanding these interconnected mechanisms is crucial for developing targeted therapies. This review integrates current knowledge on the pathophysiology of MASLD, emphasizing emerging concepts such as lean metabolic dysfunction-associated steatohepatitis (MASH), epigenetic alterations, hepatic extracellular vesicles, and the relevance of extrahepatic signals. It also discusses novel therapeutic strategies under investigation, aiming to provide a comprehensive and structured overview of the evolving MASLD landscape for both basic scientists and clinicians.
C1 [Kuchay, Mohammad Shafi] Medanta, Div Endocrinol & Metab, Gurugram, India.
   [Choudhary, Narendra Singh] Medanta, Inst Digest & Hepatobiliary Sci, Gurugram, India.
   [Ramos-Molina, Bruno] Biomed Res Inst Murcia IMIB, Grp Obes Diabet & Metab, Murcia, Spain.
RP Kuchay, MS (corresponding author), Medanta, Div Endocrinol & Metab, Gurugram, India.; Ramos-Molina, B (corresponding author), Biomed Res Inst Murcia IMIB, Grp Obes Diabet & Metab, Murcia, Spain.
EM drshafikuchay@gmail.com; brunoramosmolina@gmail.com
RI Kuchay, M/IZQ-0398-2023; Ramos-Molina, Bruno/K-8303-2019; Ramos-Molina,
   Bruno/A-4574-2017
OI Ramos-Molina, Bruno/0000-0001-6804-5449
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NR 309
TC 0
Z9 0
U1 1
U2 1
PU AMER PHYSIOLOGICAL SOC
PI Rockville
PA 6120 Executive Blvd, Suite 600, Rockville, MD, UNITED STATES
SN 0363-6143
EI 1522-1563
J9 AM J PHYSIOL-CELL PH
JI Am. J. Physiol.-Cell Physiol.
PD MAY 17
PY 2025
VL 328
IS 5
BP C1637
EP C1666
DI 10.1152/ajpcell.00951.2024
PG 30
WC Cell Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Physiology
GA 2JK0N
UT WOS:001484068600004
PM 40244183
DA 2025-06-11
ER

PT J
AU Ros, E
   Singh, A
   O'Keefe, JH
AF Ros, Emilio
   Singh, Annapoorna
   O'Keefe, James H.
TI Nuts: Natural Pleiotropic Nutraceuticals
SO NUTRIENTS
LA English
DT Review
DE tree nuts; peanuts; fatty acids; prospective studies; randomized
   clinical trials; cardiovascular risk; type-2 diabetes; cancer;
   hypertension; cognitive function; mortality; body weight; blood lipids;
   inflammation; PREDIMED
ID CARDIOMETABOLIC RISK-FACTORS; CORONARY-HEART-DISEASE; MEDITERRANEAN
   DIET; BLOOD-PRESSURE; TREE NUTS; FOOD GROUPS; CARDIOVASCULAR MORTALITY;
   NETWORK METAANALYSIS; ENDOTHELIAL FUNCTION; WALNUT CONSUMPTION
AB Common nuts (tree nuts and peanuts) are energy-dense foods that nature has gifted with a complex matrix of beneficial nutrients and bioactives, including monounsaturated and polyunsaturated fatty acids, high-quality protein, fiber, non-sodium minerals, tocopherols, phytosterols, and antioxidant phenolics. These nut components synergize to favorably influence metabolic and vascular physiology pathways, ameliorate cardiovascular risk factors and improve cardiovascular prognosis. There is increasing evidence that nuts positively impact myriad other health outcomes as well. Nut consumption is correlated with lower cancer incidence and cancer mortality, and decreased all-cause mortality. Favorable effects on cognitive function and depression have also been reported. Randomized controlled trials consistently show nuts have a cholesterol-lowering effect. Nut consumption also confers modest improvements on glycemic control, blood pressure (BP), endothelial function, and inflammation. Although nuts are energy-dense foods, they do not predispose to obesity, and in fact may even help in weight loss. Tree nuts and peanuts, but not peanut butter, generally produce similar positive effects on outcomes. First level evidence from the PREDIMED trial shows that, in the context of a Mediterranean diet, consumption of 30 g/d of nuts (walnuts, almonds, and hazelnuts) significantly lowered the risk of a composite endpoint of major adverse cardiovascular events (myocardial infarction, stroke, and death from cardiovascular disease) by approximate to 30% after intervention for 5 y. Impressively, the nut-supplemented diet reduced stroke risk by 45%. As they are rich in salutary bioactive compounds and beneficially impact various health outcomes, nuts can be considered natural pleiotropic nutraceuticals.
C1 [Ros, Emilio] Univ Barcelona, Lipid Clin, Endocrinol & Nutr Serv, Inst Invest Biomed August Pi Sunyer,Hosp Clin, Barcelona 08036, Spain.
   [Ros, Emilio] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr CIBEROBN, Madrid 28029, Spain.
   [Singh, Annapoorna; O'Keefe, James H.] Univ Missouri Kansas City, St Lukes Mid Amer Heart Inst, Kansas City, MO 64110 USA.
C3 University of Barcelona; Hospital Clinic de Barcelona; IDIBAPS;
   Instituto de Salud Carlos III; CIBER - Centro de Investigacion Biomedica
   en Red; CIBEROBN; University of Missouri System; University of Missouri
   Kansas City; Saint Luke's Mid America Heart Institute
RP Ros, E (corresponding author), Univ Barcelona, Lipid Clin, Endocrinol & Nutr Serv, Inst Invest Biomed August Pi Sunyer,Hosp Clin, Barcelona 08036, Spain.; Ros, E (corresponding author), Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr CIBEROBN, Madrid 28029, Spain.
EM eros@clinic.cat; singhann@umkc.edu; jokeefe@saintlukeskc.org
RI Singh, Annapoorna/AAY-5685-2021
OI Ros, Emilio/0000-0002-2573-1294
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NR 126
TC 72
Z9 74
U1 4
U2 63
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD SEP
PY 2021
VL 13
IS 9
AR 3269
DI 10.3390/nu13093269
PG 28
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA UW4SR
UT WOS:000700148200001
PM 34579146
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Mitra, S
   Mitra, M
   Nandi, P
   Pandey, M
   Chakrabarty, M
   Saha, M
   Nandi, DK
AF Mitra, Sudeep
   Mitra, Mousumi
   Nandi, Purna
   Pandey, Madhumita
   Chakrabarty, Mousumi
   Saha, Mantu
   Nandi, Dilip Kumar
TI Efficacy of Yoga for COVID-19 Stress Prophylaxis
SO JOURNAL OF PHYSICAL ACTIVITY & HEALTH
LA English
DT Article
DE COVID-19 pandemic; psychophysiological stress; heart rate variability
ID DEPRESSIVE SYMPTOMS; IMMUNE-RESPONSE; EXERCISE; OUTBREAK; INSULIN;
   DISEASE; IMPACT; SAMPLE; ADULTS; POWER
AB Background: The global COVID-19 lockdown restricted daily routines due to the psychological fear of infection, which imposed an unknown universal threat on female college students, affecting physiological health and well-being. However, scant information concerning the efficacy of yogic practice on female college students during the stressful COVID-19 pandemic situation is available. Methods: In a randomized controlled trial (n = 74, age = 21.65 [4.05] y), a study was conducted with a well-conceptualized yogic module for 5 days/week for 3 months (40 min daily in the morning) among yogic volunteers. Pre-post analysis of anthropometric, physiological, and biochemical indices in pandemic-stressed female college students was done for the control and yoga groups. Results: After 3 months of yogic practice, significant reduction (P <.05) in heart rate (d = 0.64, mean(diff) = 5.43), systolic blood pressure (d = 0.59, mean(diff) = 5.32), cortisol (d = 0.59, mean(diff) = 6.354), and triglycerides (P <.01, d = 0.45, mean(diff) = 13.95) was observed. After yogic follow-up significant improvement (P <.01) in high-frequency (d = 0.56, mean(diff) = -7.3), total power (d = 0.46, mean(diff) = -1150) and time domain parameters of heart rate variability led to ameliorate the stress index. Superoxide dismutase (P <.01, d = 0.78, mean(diff) = 0.69), catalase (P <.05, d = 0.48, mean(diff) = -7.37), glutathione (P <.001, d = 0.83, mean(diff) = -4.15), high-density lipoprotein (P <.05, d = 0.48, mean(diff) = -11.07), and dopamine (P <.001, d = 0.97, mean(diff) = -135.4) values along with inflammatory markers (P <.001) significantly improved among yogic volunteers after regular practice. Conclusions: Our findings suggest that a 3-month well-conceptualized yogic intervention during COVID-19 may be considered as a prophylactic tool to improve female college students' universal psychophysiological health by ameliorating autonomic functions, cardiometabolic risk factors, and immune metabolisms in an economical and environment-friendly manner.
C1 [Mitra, Sudeep; Mitra, Mousumi; Nandi, Purna; Pandey, Madhumita; Chakrabarty, Mousumi; Nandi, Dilip Kumar] Raja Narendra Lal Khan Womens Coll Autonomous, PG Dept Human Physiol & BMLT, Lab Human Performance, Midnapore, India.
   [Saha, Mantu] Def Res & Dev Org DRDO, Def Inst Physiol & Allied Sci DIPAS, Work Physiol & Yoga Lab, Delhi, India.
C3 Defence Research & Development Organisation (DRDO); Defence Institute of
   Physiology & Allied Sciences (DIPAS)
RP Nandi, DK (corresponding author), Raja Narendra Lal Khan Womens Coll Autonomous, PG Dept Human Physiol & BMLT, Lab Human Performance, Midnapore, India.
EM dilipnandi2004@yahoo.co.in
RI Mitra, Dr. Mousumi/AHE-9076-2022; Nandi, Dilip/AAS-4886-2021
OI MITRA, SUDEEP/0000-0001-7891-5946
FU LSRB, DRDO-DIPAS, Ministry of Defence, India [O/o
   DG(TM)/81/48222/LSRB-349/PEE BS/2019]
FX The authors express their sincere regard and heartfelt gratitude to the
   honorable director Dr. Rajeev Varshney, concerned scientists of Defence
   Institute of Physiology and Allied Sciences and Life Sciences Research
   Board members of Defence Research and Development Organisation for their
   immense amount of suggestions, feedback, and guidance during the entire
   study period. Finally, the authors would like to acknowledge all the
   volunteers, support staff, and yoga trainers who were engaged in the
   study. The authors also acknowledge the Department of Science &
   Technology Fund for Improvement of S&T Infrastructure for certain
   instrumental support. This study was funded by LSRB, DRDO-DIPAS,
   Ministry of Defence, India; sanction no.: O/o
   DG(TM)/81/48222/LSRB-349/PEE& BS/2019. The data used to support the
   findings of this study are included within this article.
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NR 64
TC 4
Z9 4
U1 0
U2 8
PU HUMAN KINETICS PUBL INC
PI CHAMPAIGN
PA 1607 N MARKET ST, PO BOX 5076, CHAMPAIGN, IL 61820-2200 USA
SN 1543-3080
EI 1543-5474
J9 J PHYS ACT HEALTH
JI J. Phys. Act. Health
PD NOV
PY 2023
VL 20
IS 11
BP 1034
EP 1042
DI 10.1123/jpah.2023-0035
EA AUG 2023
PG 9
WC Public, Environmental & Occupational Health
WE Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA Y2UM2
UT WOS:001061693700001
PM 37625797
DA 2025-06-11
ER

PT J
AU Alnandi, A
   John, A
   Raza, H
AF Alnandi, Arwa
   John, Annie
   Raza, Haider
TI Mitigation of Glucolipotoxicity-Induced Apoptosis, Mitochondrial
   Dysfunction, and Metabolic Stress by N-Acetyl Cysteine in
   Pancreatic β-Cells
SO BIOMOLECULES
LA English
DT Article
DE glucolipotoxicity; palmitic acid; Rin-5F cells; mitochondrial
   dysfunction; autophagy; apoptosis
ID INCREASED OXIDATIVE STRESS; FATTY-ACIDS; INSULIN-RESISTANCE; AUTOPHAGY;
   GLUCOSE; LIPOTOXICITY; GLUCOTOXICITY; PERMEABILITY; TOXICITY; OBESITY
AB Glucolipotoxicity caused by hyperglycemia and hyperlipidemia are the common features of diabetes-induced complications. Metabolic adaptation, particularly in energy metabolism; mitochondrial dysfunction; and increased inflammatory and oxidative stress responses are considered to be the main characteristics of diabetes and metabolic syndrome. However, due to various fluctuating endogenous and exogenous stimuli, the precise role of these factors under in vivo conditions is not clearly understood. In the present study, we used pancreatic beta-cells, Rin-5F, to elucidate the molecular and metabolic changes in glucolipotoxicity. Cells treated with high glucose (25 mM) and high palmitic acid (up to 0.3 mM) for 24 h exhibited increased caspase/poly-ADP ribose polymerase (PARP)-dependent apoptosis followed by DNA fragmentation, alterations in mitochondrial membrane permeability, and bioenergetics, accompanied by alterations in glycolytic and mitochondrial energy metabolism. Our results also demonstrated alterations in the expression of mammalian target of rapamycin (mTOR)/5 ' adenosine monophosphate-activated protein kinase (AMPK)-dependent apoptotic and autophagy markers. Furthermore, pre-treatment of cells with 10 mM N-acetyl cysteine attenuated the deleterious effects of high glucose and high palmitic acid with improved cellular functions and survival. These results suggest that the presence of high energy metabolites enhance mitochondrial dysfunction and apoptosis by suppressing autophagy and adapting energy metabolism, mediated, at least in part, via enhanced oxidative DNA damage and mTOR/AMPK-dependent cell signaling.
C1 [Alnandi, Arwa; John, Annie; Raza, Haider] United Arab Emirates Univ, Coll Med & Hlth Sci, Dept Biochem, POB 17666, Al Ain, U Arab Emirates.
   [Alnandi, Arwa] Minist Hlth & Prevent, POB 4724, Ras Al Khaymah, U Arab Emirates.
C3 United Arab Emirates University
RP Raza, H (corresponding author), United Arab Emirates Univ, Coll Med & Hlth Sci, Dept Biochem, POB 17666, Al Ain, U Arab Emirates.
EM 200770005@uaeu.ac.ae; anniej@uaeu.ac.ae; h.raza@uaeu.ac.ae
FU Sheikh Hamdan Medical Research Award [MRG-18/2013-2014]; Research
   Committee, College of Medicine and Health Sciences, UAE University, Al
   Ain, UAE [HR-31M377]
FX This research was funded by the Sheikh Hamdan Medical Research Award
   (MRG-18/2013-2014) and the Research Committee, College of Medicine and
   Health Sciences, UAE University, Al Ain, UAE (HR-31M377).
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NR 53
TC 11
Z9 11
U1 0
U2 4
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2218-273X
J9 BIOMOLECULES
JI Biomolecules
PD FEB
PY 2020
VL 10
IS 2
AR 239
DI 10.3390/biom10020239
PG 18
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA KX8QD
UT WOS:000522138500183
PM 32033264
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Molina, MN
   Ferder, L
   Manucha, W
AF Nile Molina, Marisa
   Ferder, Leon
   Manucha, Walter
TI Emerging Role of Nitric Oxide and Heat Shock Proteins in Insulin
   Resistance
SO CURRENT HYPERTENSION REPORTS
LA English
DT Review
DE Insulin resistance; Nitric oxide; Heat shock protein 70; Type-2 diabetes
   mellitus; Oxidative stress; Vitamin D
ID DIET-INDUCED OBESITY; TYPE-2 DIABETES-MELLITUS; FREE FATTY-ACIDS;
   VITAMIN-D; OXIDATIVE STRESS; SKELETAL-MUSCLE; ANGIOTENSIN-II; SIGNALING
   PATHWAYS; HEAT-SHOCK-PROTEIN-70 HSP70; MITOCHONDRIAL DYSFUNCTION
AB Insulin resistance (IR) is present in pathologies such as diabetes, obesity, metabolic syndrome, impaired glucose tolerance, hypertension, inflammation, cardiac disease, and dyslipidemias. Population studies show that IR is multifactorial and has genetic components, such as defects in the insulin-signaling pathway (as serine phosphorylation on insulin substrate or decreased activation of signaling molecules) and RAS/MAPK-dependent pathways. IR is connected to mitochondrial dysfunction, overproduction of oxidants, accumulation of fat, and an over-activation of the renin-angiotensin system linked to the NADPH oxidase activity. In addition, nitric oxide (NO), synthesized by nitric oxide synthases (endothelial and inducible), is also associated with IR when both impaired release and reduced bioavailability of all which lead to inflammation and hypertension. However, increased NO may promote vasculoprotection. Moreover, reduced NO release induces heat shock protein 70 kDa (HSP70) expression in IR and diabetes, mediating beneficial effects against oxidative stress injury, inflammation and apoptosis. HSP70 may be used as biomarker of the chronicity of diabetes. Hsp72 (inducible protein) is linked to vascular complications with a high-fat diet by blocking inflammation signaling (cytoprotective and anti-cytotoxicity intracellular role). Elucidating the IR signaling pathways and the roles of NO and HSPs is relevant to the application of new treatments, such as heat shock and thermal therapy, nitrosylated drugs, chemical chaperones or exercise training.
C1 [Nile Molina, Marisa] Univ Juan Agustin Maza, Fac Farm & Bioquim, Catedra Quim Organ 2, Mendoza, Argentina.
   [Ferder, Leon] Univ Puerto Rico, Sch Med, Dept Physiol & Pharmacol, San Juan, PR 00936 USA.
   [Manucha, Walter] Univ Nacl Cuyo, Ctr Univ, Fac Ciencias Med, Area Farmacol,Dept Patol, RA-5500 Mendoza, Argentina.
   [Manucha, Walter] IMBECU CONICET Natl Council Sci & Tech Res Argent, Mendoza, Argentina.
C3 University of Puerto Rico; University of Puerto Rico Medical Sciences
   Campus; University Nacional Cuyo Mendoza; Consejo Nacional de
   Investigaciones Cientificas y Tecnicas (CONICET)
RP Manucha, W (corresponding author), Univ Nacl Cuyo, Ctr Univ, Fac Ciencias Med, Area Farmacol,Dept Patol, RA-5500 Mendoza, Argentina.; Manucha, W (corresponding author), IMBECU CONICET Natl Council Sci & Tech Res Argent, Mendoza, Argentina.
EM wmanucha@yahoo.com.ar
OI Manucha, Walter/0000-0002-2279-7626
FU Research and Technology Council of Cuyo University (SECyT), Mendoza,
   Argentina; National Council of Scientific and Technical Research
   (CONICET) PIP;  [PICT 2012-0234];  [BID 2777 OC/AR]
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: This work
   was supported by grants from the Research and Technology Council of Cuyo
   University (SECyT), Mendoza, Argentina, and from the National Council of
   Scientific and Technical Research (CONICET) PIP 2010-2012, both of which
   were awarded to Walter Manucha. Grant no. PICT 2012-0234, BID 2777
   OC/AR.
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NR 153
TC 87
Z9 90
U1 0
U2 15
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1522-6417
EI 1534-3111
J9 CURR HYPERTENS REP
JI Curr. Hypertens. Rep.
PD JAN
PY 2016
VL 18
IS 1
AR 1
DI 10.1007/s11906-015-0615-4
PG 13
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA DC5JS
UT WOS:000369257900008
PM 26694820
DA 2025-06-11
ER

PT J
AU Ross, AP
   Darling, JN
   Parent, MB
AF Ross, Amy P.
   Darling, Jenna N.
   Parent, Manse B.
TI Excess intake of fat and sugar potentiates epinephrine-induced
   hyperglycemia in male rats
SO JOURNAL OF DIABETES AND ITS COMPLICATIONS
LA English
DT Article
DE Non-alcoholic fatty liver; Obesity; Insulin resistance; Cafeteria-style
   diet; Steatosis
ID BLOOD-GLUCOSE LEVELS; HIPPOCAMPAL-DEPENDENT MEMORY; INDUCED
   INSULIN-RESISTANCE; BODY-MASS INDEX; METABOLIC SYNDROME; LIVER-DISEASE;
   CARDIOVASCULAR RISK; DIABETES-MELLITUS; ABDOMINAL OBESITY;
   BETA-ENDORPHIN
AB Aims: Over the past five decades, per capita caloric intake has increased significantly, and diet- and stress-related diseases are more prevalent. The stress hormone epinephrine stimulates hepatic glucose release during a stress response. The present experiment tested the hypothesis that excess caloric intake alters this ability of epinephrine to increase blood glucose.
   Methods: Sprague-Dawley rats were fed a high-energy cafeteria-style diet (HED). Weight gain during the first 5 days on the diet was used to divide the rats into an HED-lean group and HED-obese group. After 9 weeks, the rats were injected with epinephrine, and blood glucose was measured.
   Results: HED-obese rats gained body and fat mass, and developed insulin resistance (IR) and hepatic steatosis. HED-lean and control rats did not differ. Epinephrine produced larger increases in blood glucose in the HED-obese rats than in the HED-lean and control rats. Removing the high-energy components of the diet for 4 weeks reversed the potentiated effects of epinephrine on glucose and corrected the IR but not the steatosis or obesity.
   Conclusions: Consumption of a high-energy cafeteria diet potentiates epinephrine-induced hyperglycemia. This effect is associated with insulin resistance but not adiposity or steatosis and is reversed by 4 weeks of standard chow. (C) 2015 Elsevier Inc. All rights reserved.
C1 [Ross, Amy P.; Darling, Jenna N.; Parent, Manse B.] Georgia State Univ, Inst Neurosci, Atlanta, GA 30302 USA.
C3 University System of Georgia; Georgia State University
RP Parent, MB (corresponding author), Georgia State Univ, Inst Neurosci, POB 5030, Atlanta, GA 30302 USA.
EM mbparent@gsu.edu
FU National Science Foundation [MCB-1121886]; STC Program of the National
   Science Foundation [IBN-9876754]; Direct For Biological Sciences;
   Division Of Integrative Organismal Systems [1121886] Funding Source:
   National Science Foundation
FX This research was supported by the National Science Foundation
   (MCB-1121886), and the STC Program of the National Science Foundation
   (IBN-9876754). These funding sources were not involved in the design,
   data collection, analysis or interpretation, or in writing this
   manuscript. We would like to thank Jenine Ampudia, Lalita Balakrishnan,
   Grace Igbinigie, Saima Masud, and Christopher Mylenbusch for their
   technical assistance. We would also like to thank the Honeycutt family
   for their generous financial support to APR. All three authors were
   involved in the conception and design of the experiments, the
   collection, analysis and interpretation of data, and the drafting and
   revising of the manuscript.
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NR 73
TC 7
Z9 10
U1 0
U2 10
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1056-8727
EI 1873-460X
J9 J DIABETES COMPLICAT
JI J. Diabetes Complications
PD APR
PY 2015
VL 29
IS 3
BP 329
EP 337
DI 10.1016/j.jdiacomp.2014.12.017
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA CE8TN
UT WOS:000352117100003
PM 25716573
DA 2025-06-11
ER

PT J
AU Aydin, O
   Ellidag, HY
   Eren, E
   Ay, N
   Yalcinkaya, S
   Yilmaz, N
AF Aydin, Ozgur
   Ellidag, Hamit Yasar
   Eren, Esin
   Ay, Nurullah
   Yalcinkaya, Soner
   Yilmaz, Necat
TI INCREASED ANTIOXIDANT QUALITY VERSUS LOWER QUANTITY OF HIGH DENSITY
   LIPOPROTEIN IN BENIGN PROSTATIC HYPERPLASIA
SO JOURNAL OF MEDICAL BIOCHEMISTRY
LA English
DT Article
DE oxidative stress; total antioxidant status; total oxidant status;
   adjusted paraoxonase and arylesterase; HDL functionality; metabolic
   syndrome
ID SERUM PARAOXONASE ARYLESTERASE; OXIDATIVE STRESS; CANCER
AB Background: Oxidative stress may be involved in the pathogenesis of every human disease. To understand its possible role in benign prostatic hyperplasia (BPH), we measured the overall oxidative status of patients with BPH and the serum activity of the high density lipoprotein (HDL)-related antioxidant enzymes paraoxonase 1 (PON1) and arylesterase (ARE).
   Methods: Fifty-six urology outpatient clinic patients with BPH (mean age 64 +/- 8.6 years) were prospectively included in the study. Forty volunteer healthy controls from the laboratory staff (mean age 62 +/- 10 years) were enrolled for comparison. Serum total antioxidant status (TAS), total oxidant status (TOS), PON1, ARE, and HDL levels were measured by commercially available, ready-to-use kits.
   Results: Serum TAS and HDL levels were significantly lower in the BPH group than in the control group (P=0.004 and P=0.02, respectively). No significant between-group differences were observed for TOS levels or PON1 and ARE enzyme activities (P=0.30, P=0.89, and P=0.74, respectively). In the BPH group, the calculated parameters PON1/HDL and ARE/HDL were significantly higher (P=0.02 and P=0.04, respectively).
   Conclusions: Our findings agree with the previous reports of impaired oxidant/antioxidant balance in BPH patients. The activities of HDL-related enzymes between groups with significantly different HDL levels may be deceptive; adjusted values may help to reach more accurate conclusions.
C1 [Aydin, Ozgur] Batman Matern & Childrens Hosp, Clin Biochem, Minist Hlth, TR-72000 Batman, Turkey.
   [Ellidag, Hamit Yasar; Yilmaz, Necat] Antalya Educ & Res Hosp Minist Hlth, Cent Labs, Antalya, Turkey.
   [Eren, Esin] Minist Hlth, Antalya Publ Hlth Ctr, Clin Biochem, Antalya, Turkey.
   [Ay, Nurullah] Tatvan Mil Hosp, Clin Biochem, Bitlis, Turkey.
   [Yalcinkaya, Soner] Antalya Educ & Res Hosp, Urol Clin, Minist Hlth, Antalya, Turkey.
C3 Batman Maternity & Child Health Hospital; Ministry of Health - Turkey;
   Antalya Training & Research Hospital; Ministry of Health - Turkey;
   Antalya Ataturk State Hospital; Ministry of Health - Turkey; Tatvan
   Military Hospital; Ministry of Health - Turkey; Antalya Ataturk State
   Hospital; Antalya Training & Research Hospital
RP Aydin, O (corresponding author), Batman Matern & Childrens Hosp, Ziya Gokalp Mah SSK Cad, TR-72000 Batman, Turkey.
EM ozgurchem@yahoo.com
RI aydin, ozgur/C-1191-2013; ellidag, hamit yasar/I-1335-2014
OI aydin, ozgur/0000-0002-6123-6186; ellidag, hamit
   yasar/0000-0002-7511-2547; Ay, Nurullah/0000-0002-0122-5725
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NR 18
TC 0
Z9 0
U1 0
U2 2
PU SCIENDO
PI WARSAW
PA DE GRUYTER POLAND SP Z O O, BOGUMILA ZUGA 32A STR, 01-811 WARSAW, POLAND
SN 1452-8258
EI 1452-8266
J9 J MED BIOCHEM
JI J. Med. Biochem.
PD OCT-DEC
PY 2015
VL 34
IS 4
BP 455
EP 459
DI 10.2478/jomb-2014-0053
PG 5
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA CT7OC
UT WOS:000363003400009
PM 28356855
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Semlitsch, M
   Shackelford, RE
   Zirkl, S
   Sattler, W
   Malle, E
AF Semlitsch, Michaela
   Shackelford, Rodney E.
   Zirkl, Sandra
   Sattler, Wolfgang
   Malle, Ernst
TI ATM protects against oxidative stress induced by oxidized low-density
   lipoprotein
SO DNA REPAIR
LA English
DT Article
DE ROS; Modified LDL; DNA-double-strand breaks; Atherosclerosis; p21;
   Colony forming efficiency assay; EA.hy926 cells; Hydrogen peroxide
ID DNA-DAMAGE RESPONSE; TELANGIECTASIA GENE-PRODUCT; ATAXIA-TELANGIECTASIA;
   DEFICIENT MICE; HISTONE H2AX; PYRROLIDINE DITHIOCARBAMATE; MITOCHONDRIAL
   DYSFUNCTION; METABOLIC SYNDROME; FREE-RADICALS; MODIFIED LDL
AB Chronic oxidative stress is involved in the pathogenesis of multiple inflammatory diseases, including cardiovascular disease and atherosclerosis. The rare autosomal recessive disorder Ataxia-telangiectasia (A-T) is characterized by progressive cerebellar ataxia secondary to Purkinje cell death, immunodeficiency, and increased cancer incidence. ATM, the protein mutated in A-T, plays a key role in cellular DNA-damage responses. A-T cells show poor cellular anti-oxidant defences and increased oxidant sensitivity compared to normal cells, and ATM functions, in part, as an oxidative stress sensor. The oxidation of low-density lipoprotein (oxLDL) and its uptake by macrophages is an initiating step in the development of atherosclerosis. We demonstrate that oxLDL activates ATM and downstream p21 expression in normal fibroblasts and endothelial cells. In ATM-deficient fibroblasts oxLDL induces DNA double-strand breaks, micronuclei formation and causes chromosome breaks. Furthermore, oxLDL decreases cell viability and inhibits colony formation in A-T fibroblasts more effectively as compared to normal controls. Formation of oxLDL-induced reactive oxygen species is significantly higher in A-T, than normal fibroblasts. Last, pre-treatment of cells with ammonium pyrrolidine dithiocarbamate, a potent antioxidant and inhibitor of transcription factor nuclear factor KB, reduces oxLDL-induced reactive oxygen species formation. Our data indicates that ATM functions in the defence against oxLDL-mediated cytotoxicity. (C) 2011 Elsevier B.V. All rights reserved.
C1 [Semlitsch, Michaela; Zirkl, Sandra; Sattler, Wolfgang; Malle, Ernst] Med Univ Graz, Ctr Mol Med, Inst Mol Biol & Biochem, A-8010 Graz, Austria.
   [Shackelford, Rodney E.] Tulane Univ Hlth Sci, Dept Pathol & Lab Med, New Orleans, LA USA.
C3 Medical University of Graz; Tulane University; Tulane University
   Hospital
RP Malle, E (corresponding author), Med Univ Graz, Ctr Mol Med, Inst Mol Biol & Biochem, Harrachgasse 21, A-8010 Graz, Austria.
EM ernst.malle@medunigraz.at
RI Malle, Ernst/D-3071-2013
FU The Austrian Science Fund (FWF) [P19074-B05, F3007]; Bank Austria
FX AT22 cells were kindly provided by Dr. Yosef Shiloh (Sackler School of
   Medicine, Tel Aviv University, Tel Aviv, Israel). The Austrian Science
   Fund (FWF) provided financial support (P19074-B05 and F3007). R.S. was
   supported by a Bank Austria Visiting Scientists Program provided to the
   Medical University of Graz, Austria. The authors are grateful to Drs. M.
   Vadon and S. Sipurzynski (Medical University of Graz) for providing
   human plasma.
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PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1568-7864
J9 DNA REPAIR
JI DNA Repair
PD AUG 15
PY 2011
VL 10
IS 8
BP 848
EP 860
DI 10.1016/j.dnarep.2011.05.004
PG 13
WC Genetics & Heredity; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Genetics & Heredity; Toxicology
GA 809EE
UT WOS:000294033800007
PM 21669554
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Tudor, L
   Konjevod, M
   Erjavec, GN
   Perkovic, MN
   Uzun, S
   Kozumplik, O
   Zoldos, V
   Lauc, G
   Strac, DS
   Pivac, N
AF Tudor, Lucija
   Konjevod, Marcela
   Erjavec, Gordana Nedic
   Perkovic, Matea Nikolac
   Uzun, Suzana
   Kozumplik, Oliver
   Zoldos, Vlatka
   Lauc, Gordan
   Strac, Dubravka Svob
   Pivac, Nela
TI Genetic and Epigenetic Association of Hepatocyte Nuclear Factor-1α with
   Glycosylation in Post-Traumatic Stress Disorder
SO GENES
LA English
DT Article
DE post-traumatic stress disorder; HNF1A; glycomics; N-glycans;
   polymorphism; methylation; inflammation
ID C-REACTIVE PROTEIN; HNF1A GENE; METABOLIC-SYNDROME; N-GLYCOSYLATION;
   ALPHA-GENE; PLASMA; POPULATION; SUSCEPTIBILITY; POLYMORPHISMS; VARIANTS
AB Post-traumatic stress disorder (PTSD) is a complex trauma-related disorder, the etiology and underlying molecular mechanisms of which are still unclear and probably involve different (epi)genetic and environmental factors. Protein N-glycosylation is a common post-translational modification that has been associated with several pathophysiological states, including inflammation and PTSD. Hepatocyte nuclear factor-1 alpha (HNF1A) is a transcriptional regulator of many genes involved in the inflammatory processes, and it has been identified as master regulator of plasma protein glycosylation. The aim of this study was to determine the association between N-glycan levels in plasma and immunoglobulin G, methylation at four CpG positions in the HNF1A gene, HNF1A antisense RNA 1 (HNF1A-AS1), rs7953249 and HNF1A rs735396 polymorphisms in a total of 555 PTSD and control subjects. We found significant association of rs7953249 and rs735396 polymorphisms, as well as HNF1A gene methylation at the CpG3 site, with highly branched, galactosylated and sialyated plasma N-glycans, mostly in patients with PTSD. HNF1A-AS1 rs7953249 polymorphism was also associated with PTSD; however, none of the polymorphisms were associated with HNF1A gene methylation. These results indicate a possible regulatory role of the investigated HNF1A polymorphisms with respect to the abundance of complex plasma N-glycans previously associated with proinflammatory response, which could contribute to the clinical manifestation of PTSD and its comorbidities.
C1 [Tudor, Lucija; Konjevod, Marcela; Erjavec, Gordana Nedic; Perkovic, Matea Nikolac; Strac, Dubravka Svob; Pivac, Nela] Rudjer Boskovic Inst, Div Mol Med, Lab Mol Neuropsychiat, Zagreb 10000, Croatia.
   [Uzun, Suzana; Kozumplik, Oliver] Univ Hosp Vrapce, Dept Biol Psychiat & Psychogeriatr, Zagreb 10000, Croatia.
   [Uzun, Suzana] Univ Zagreb, Sch Med, Zagreb 10000, Croatia.
   [Uzun, Suzana; Kozumplik, Oliver] Univ Zagreb, Fac Educ & Rehabil Sci, Zagreb 10000, Croatia.
   [Zoldos, Vlatka] Univ Zagreb, Fac Sci, Dept Biol, Div Mol Biol, Zagreb 10000, Croatia.
   [Lauc, Gordan] Genos Ltd, Glycobiol Lab, Zagreb 10000, Croatia.
C3 Rudjer Boskovic Institute; University of Zagreb; University of Zagreb;
   University of Zagreb
RP Pivac, N (corresponding author), Rudjer Boskovic Inst, Div Mol Med, Lab Mol Neuropsychiat, Zagreb 10000, Croatia.
EM lucija.tudor@irb.hr; marcela.konjevod@irb.hr;
   gordana.nedic.erjavec@irb.hr; matea.nikolac.perkovic@irb.hr;
   suzana.uzun@gmail.com; okozumplik@hotmail.com; vzoldos@biol.pmf.hr;
   glauc@genos.hr; dsvob@irb.hr; npivac@irb.hr
RI Nedic Erjavec, Gordana/C-5149-2013; Konjevod, Marcela/AAU-8840-2020;
   Nikolac Perkovic, Matea/E-7943-2013; Lauc, Gordan/K-5864-2012
OI Svob Strac, Dubravka/0000-0001-6200-2405; Tudor,
   Lucija/0000-0002-9125-406X; Nedic Erjavec, Gordana/0000-0002-0787-9340;
   Nikolac Perkovic, Matea/0000-0002-3113-0778; Lauc,
   Gordan/0000-0003-1840-9560
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NR 69
TC 2
Z9 2
U1 0
U2 4
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2073-4425
J9 GENES-BASEL
JI Genes
PD JUN
PY 2022
VL 13
IS 6
AR 1063
DI 10.3390/genes13061063
PG 20
WC Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Genetics & Heredity
GA 8V1EG
UT WOS:000930381400001
PM 35741825
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Son, HK
   Xiang, H
   Park, S
   Lee, J
   Lee, JJ
   Jung, S
   Ha, JH
AF Son, Hee-Kyoung
   Xiang, Huo
   Park, Seohyun
   Lee, Jisu
   Lee, Jae-Joon
   Jung, Sunyoon
   Ha, Jung-Heun
TI Partial Replacement of Dietary Fat with Polyunsaturated Fatty Acids
   Attenuates the Lipopolysaccharide-Induced Hepatic Inflammation in
   Sprague-Dawley Rats Fed a High-Fat Diet
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Article
DE high-fat diet; lipopolysaccharide; polyunsaturated fatty acids; perilla
   oil; corn oil; inflammation
ID ENDOPLASMIC-RETICULUM STRESS; INSULIN-RESISTANCE; LIVER-DISEASE;
   METABOLIC SYNDROME; DOSE ENDOTOXIN; TNF-ALPHA; VITAMIN-E; OBESITY;
   ACCUMULATION; DYSLIPIDEMIA
AB In this study, we investigated whether the partial replacement of dietary fat with polyunsaturated fatty acids (PUFAs) ameliorated the lipopolysaccharide (LPS)-induced hepatic inflammation in rats fed a high-fat diet. Male Sprague-Dawley rats were divided into three groups and provided each of the following diets: (1) high-fat diet (HFD), (2) HFD with perilla oil (PO), and (3) HFD with corn oil (CO). After 12 weeks of dietary intervention, the rats were intraperitoneally injected with LPS (5 mg/kg) from Escherichia coli O55:B5 or phosphate-buffered saline (PBS). Following LPS stimulation, serum insulin levels were increased, while PO and CO lowered the serum levels of glucose and insulin. In the liver, LPS increased the triglyceride levels, while PO and CO alleviated the LPS-induced hepatic triglyceride accumulation. In the LPS injected rats, the mRNA expression of genes related to inflammation and endoplasmic reticulum (ER) stress was attenuated by PO and CO in the liver. Furthermore, hepatic levels of proteins involved in the nuclear factor kappa-light-chain-enhancer of activated B cells/mitogen-activated protein kinase pathways, antioxidant response, and ER stress were lowered by PO- and CO-replacement. Therefore, the partial replacement of dietary fat with PUFAs alleviates LPS-induced hepatic inflammation during HFD consumption, which may decrease metabolic abnormalities.</p>
C1 [Son, Hee-Kyoung; Xiang, Huo; Park, Seohyun; Lee, Jisu; Jung, Sunyoon; Ha, Jung-Heun] Dankook Univ, Res Ctr Industralizat Nat Neutralizat, Cheonan 31116, South Korea.
   [Xiang, Huo; Park, Seohyun; Lee, Jisu; Jung, Sunyoon; Ha, Jung-Heun] Dankook Univ, Dept Food Sci & Nutr, Cheonan 31116, South Korea.
   [Lee, Jae-Joon] Chosun Univ, Dept Food & Nutr, Gwangju 61452, South Korea.
C3 Dankook University; Dankook University; Chosun University
RP Jung, S; Ha, JH (corresponding author), Dankook Univ, Res Ctr Industralizat Nat Neutralizat, Cheonan 31116, South Korea.; Jung, S; Ha, JH (corresponding author), Dankook Univ, Dept Food Sci & Nutr, Cheonan 31116, South Korea.
EM kyoung1033@dankook.ac.kr; waitfor0126@naver.com; sb5590@naver.com;
   dlwltn970811@naver.com; leejj80@chosun.ac.kr; syjung583@dankook.ac.kr;
   ha@dankook.ac.kr
RI Lee, Joo-Hyun/ISA-7761-2023; Jung, Sunyoon/AAL-1217-2021
OI Lee, Jae-Joon/0000-0001-5737-612X; Lee, JiSu/0000-0002-3327-1945; HA,
   JUNG-HEUN/0000-0001-5282-531X; Jung, Sunyoon/0000-0001-9217-5649
FU Korea Institute of Planning and Evaluation for Technology in Food,
   Agriculture and Forestry (IPET) through Innovative Food Product and
   Natural Food Materials Development Program - Ministry of Agriculture,
   Food and Rural Affairs (MAFRA) [319045-3]
FX FundingThis work was supported by Korea Institute of Planning and
   Evaluation for Technology in Food, Agriculture and Forestry (IPET)
   through Innovative Food Product and Natural Food Materials Development
   Program, funded by Ministry of Agriculture, Food and Rural Affairs
   (MAFRA) (319045-3).
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NR 91
TC 11
Z9 11
U1 0
U2 7
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD OCT
PY 2021
VL 18
IS 20
AR 10986
DI 10.3390/ijerph182010986
PG 26
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA WQ4PX
UT WOS:000713801400001
PM 34682732
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Wikan, N
   Tocharus, J
   Sivasinprasasn, S
   Kongkaew, A
   Chaichompoo, W
   Suksamrarn, A
   Tocharus, C
AF Wikan, Naruemon
   Tocharus, Jiraporn
   Sivasinprasasn, Sivanan
   Kongkaew, Aphisek
   Chaichompoo, Waraluck
   Suksamrarn, Apichart
   Tocharus, Chainarong
TI Capsaicinoid nonivamide improves nonalcoholic fatty liver disease in
   rats fed a high-fat diet
SO JOURNAL OF PHARMACOLOGICAL SCIENCES
LA English
DT Article
DE Nonivamide; NAFLD; High-fat diet; Hepatic injury; Lipid accumulation
ID INSULIN-RESISTANCE; OXIDATIVE STRESS; ENERGY-METABOLISM; HEPATIC
   STEATOSIS; EXPRESSION; CURCUMIN; OBESITY; INFLAMMATION; EXTRACTION;
   APOPTOSIS
AB Nonalcoholic fatty liver disease (NAFLD) is a chronic disease that causes morbidity associated with metabolic syndrome. NAFLD is a worldwide problem and represents a major cause of liver injury, which can lead to liver cell death. We investigated the effects of nonivamide (pelargonic acid vanillylamide, PAVA; 1 mg/kg) and rosuvastatin (RSV; 10 mg/kg) on hepatic steatosis induced by a high-fat diet (HFD). Male SpragueeDawley rats were fed a HFD for 16 weeks then received PAVA or RSV for 4 additional weeks. We examined the metabolic parameters, function, fat content, histological alterations, reactive oxygen species production, and apoptotic cell death of the liver, in addition to the expression of the following important molecules: transient receptor potential cation channel subfamily V member 1 (TRPV1) phosphorylation of sterol regulatory element binding protein (pSREBP-1c/SREBP-1c), total and membrane glucose transporter 2 (GLUT2), 4-hydroxynonenal (4-HNE), and cleaved caspase-3. HFD-induced hepatic steatosis was associated with significantly increased morphological disorganization, injury markers, oxidative stress, lipid peroxidation, and apoptosis. However, metabolic dysfunction and hepatic injury were reduced by RSV and PAVA treatment. PAVA regulated lipid deposition, improved insulin resistance, and decreased oxidative stress and apoptotic cell death. Therefore, PAVA represents a promising therapeutic approach for treating metabolic disorders in patients with NAFLD. (C) 2020 The Authors. Production and hosting by Elsevier B.V. on behalf of Japanese Pharmacological Society.
C1 [Wikan, Naruemon; Sivasinprasasn, Sivanan; Tocharus, Chainarong] Chiang Mai Univ, Fac Med, Dept Anat, Chiang Mai 50200, Thailand.
   [Tocharus, Jiraporn] Chiang Mai Univ, Fac Med, Dept Physiol, Chiang Mai, Thailand.
   [Kongkaew, Aphisek] Chiang Mai Univ, Fac Med, Res Adm Sect, Chiang Mai, Thailand.
   [Chaichompoo, Waraluck; Suksamrarn, Apichart] Ramkhamhang Univ, Fac Sci, Dept Chem, Bangkok, Thailand.
   [Chaichompoo, Waraluck; Suksamrarn, Apichart] Ramkhamhang Univ, Fac Sci, Ctr Excellence Innovat Chem, Bangkok, Thailand.
C3 Chiang Mai University; Chiang Mai University; Chiang Mai University;
   Ramkhamhaeng University; Ramkhamhaeng University
RP Tocharus, C (corresponding author), Chiang Mai Univ, Fac Med, Dept Anat, Chiang Mai 50200, Thailand.
EM chainarongt@hotmail.com
RI Tocharus, Jiraporn/AFL-8828-2022; Suksamrarn, Apichart/R-8782-2019;
   Chaichompoo, Waraluck/GZA-3308-2022
FU Chiang Mai University; Functional Food Research Center for Well-being,
   Chiang Mai University; Thailand Research Fund [DBG6180030]; Graduate
   School and Faculty of Medicine, Chiang Mai University, Thailand; Center
   of Excellence for Innovation in Chemistry, Chiang Mai University; Office
   of the Higher Education Commission, Chiang Mai University; Faculty of
   Medicine, Chiang Mai University
FX This study was supported by Chiang Mai University and the Functional
   Food Research Center for Well-being, Chiang Mai University. Support from
   a Directed Basic Research Grant (DBG6180030) from the Thailand Research
   Fund and Center of Excellence for Innovation in Chemistry, Office of the
   Higher Education Commission and Faculty of Medicine, Chiang Mai
   University, is gratefully acknowledged. Naruemon Wikan acknowledges
   financial support from the Graduate School and Faculty of Medicine,
   Chiang Mai University, Thailand.
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NR 55
TC 13
Z9 14
U1 3
U2 22
PU JAPANESE PHARMACOLOGICAL SOC
PI KYOTO
PA EDITORIAL OFF, KANTOHYA BLDG GOKOMACHI-EBISUGAWA NAKAGYO-KU, KYOTO, 604,
   JAPAN
SN 1347-8613
EI 1347-8648
J9 J PHARMACOL SCI
JI J. Pharmacol. Sci.
PD JUL
PY 2020
VL 143
IS 3
BP 188
EP 198
DI 10.1016/j.jphs.2020.03.008
PG 11
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA LW0PJ
UT WOS:000538848400008
PM 32414691
OA gold
DA 2025-06-11
ER

PT J
AU Platzer, M
   Fellendorf, FT
   Bengesser, SA
   Birner, A
   Dalkner, N
   Hamm, C
   Hartleb, R
   Queissner, R
   Pilz, R
   Rieger, A
   Maget, A
   Mangge, H
   Zelzer, S
   Reininghaus, B
   Kapfhammer, HP
   Reininghaus, EZ
AF Platzer, Martina
   Fellendorf, Frederike T.
   Bengesser, Susanne A.
   Birner, Armin
   Dalkner, Nina
   Hamm, Carlo
   Hartleb, Riccarda
   Queissner, Robert
   Pilz, Rene
   Rieger, Alexandra
   Maget, Alexander
   Mangge, Harald
   Zelzer, Sieglinde
   Reininghaus, Bernd
   Kapfhammer, Hans-Peter
   Reininghaus, Eva Z.
TI Adiponectin is decreased in bipolar depression
SO WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
LA English
DT Article
DE Bipolar disorder; adipokines; adiponectin; leptin; obesity
ID INSULIN-RESISTANCE; METABOLIC SYNDROME; CHOLESTEROL LEVELS; LEPTIN;
   DISORDER; ADIPOKINES; OBESITY; BRAIN; COMORBIDITIES; HOMEOSTASIS
AB Objectives: Bipolar disorder (BD) is often accompanied by medical comorbidities, which affect illness course and prognosis. Adipokines may not only be involved in the aetiopathogenetic mechanisms of these comorbidities; there might be an association between adipokines and the neuropsychiatric core features of BD such as mood disturbances and cognitive deficits. Methods: In this investigation, fasting blood samples from 120 individuals with BD (75 euthymic and 45 with mild depressive symptoms) and 68 control subjects were taken and adiponectin and leptin concentrations were analysed. Results: We found that, in female participants, adiponectin levels differed significantly between patients and controls indicating lower levels in individuals with BD, even after controlling for BMI (F(1,92) = 4.65, P = 0.034, partial eta(2) = 0.05). After stratification by mood status we found a significant difference in adiponectin between controls, euthymic and depressive patients (F(2, 180) = 4.90, P = 0.008, partial eta(2) = 0.05). Conclusions: This investigation confirms previous findings of an association between low adiponectin levels and depressive state in individuals with BD. Beyond its immediate effect on central nervous system function, adiponectin might interfere with pathophysiological mechanisms of BD and its somatic comorbidities via involvement in metabolic and inflammatory processes.
C1 [Platzer, Martina; Fellendorf, Frederike T.; Bengesser, Susanne A.; Birner, Armin; Dalkner, Nina; Hamm, Carlo; Hartleb, Riccarda; Queissner, Robert; Pilz, Rene; Rieger, Alexandra; Maget, Alexander; Reininghaus, Bernd; Kapfhammer, Hans-Peter; Reininghaus, Eva Z.] Med Univ Graz, Dept Psychiat, Psychotherapy, Graz, Austria.
   [Mangge, Harald; Zelzer, Sieglinde] Med Univ Graz, Clin Inst Med,Res Unit Lifestyle, Chem Lab Diagnost,Inflammat, associated Risk Biomarkers, Graz, Austria.
   [Fellendorf, Frederike T.] Med Univ Graz, Dept Psychiat,CONTACT Frederike T,Fellendorf, Psychotherapeut Med,Auenbruggerplatz 31, Graz, Austria.
C3 Medical University of Graz; Medical University of Graz; Medical
   University of Graz
RP Fellendorf, FT (corresponding author), Med Univ Graz, Dept Psychiat, Psychotherapy, Graz, Austria.; Fellendorf, FT (corresponding author), Med Univ Graz, Dept Psychiat,CONTACT Frederike T,Fellendorf, Psychotherapeut Med,Auenbruggerplatz 31, Graz, Austria.
EM frederike.fellendorf@medunigraz.at
OI Fellendorf, Frederike/0000-0001-7215-3848; Reininghaus,
   Eva/0000-0001-5964-4087; Mangge, Harald/0000-0003-4067-247X
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NR 52
TC 25
Z9 26
U1 0
U2 5
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1562-2975
EI 1814-1412
J9 WORLD J BIOL PSYCHIA
JI World J. Biol. Psychiatry
PD NOV 26
PY 2019
VL 20
IS 10
BP 813
EP 820
DI 10.1080/15622975.2018.1500033
PG 8
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA KL3DL
UT WOS:000513307400007
PM 30047831
DA 2025-06-11
ER

PT J
AU Corfitsen, HT
   Drago, A
AF Corfitsen, Henrik Thyge
   Drago, Antonio
TI Insight gained from genome-wide interaction and enrichment analysis on
   weight gain during citalopram treatment
SO NEUROSCIENCE LETTERS
LA English
DT Article
DE Citalopram; Weight gain; GWAS; Molecular pathway
ID SEQUENCED TREATMENT ALTERNATIVES; GENE-EXPRESSION; METABOLIC SYNDROME;
   PATHWAY ANALYSIS; BODY-WEIGHT; DEPRESSION; ANTIDEPRESSANTS; ADIPONECTIN;
   MEDICATION; RATIONALE
AB Weight gain is a possible side effect of the pharmacological antidepressant treatments. Defining antidepressant prescriptions based on personal genetic makeups would decrease the risk of weight gain and increase the quality of the current antidepressant pharmacological treatments. 643 depressed, citalopram treated individuals with available clinical and genome-wide genetic information were investigated to identify the molecular pathways associated with weight gain. 111 individuals experienced weight gain during citalopram treatment. The axon guidance (p.adjust = 0.005) and the developmental biology pathway (p.adjust = 0.01) were enriched in variations associated with weight gain. The developmental biology pathway includes molecular cascades involved in the regulation of beta-cell development, and the transcriptional regulation of white adipocyte differentiation. A number of variations were harbored by genes whose products are involved in the synthesis of collagen (COL4A3, COL5A1 and ITGA1), activity of the thyroid-hormones (NCOR1 and NCOR2), energy metabolism (AD1POQ, PPARGCIA) and myogenic differentiation (CDON). A molecular pathway analysis conducted in a sample of depressed patients identified new candidate genes whose future investigation may provide insights in the molecular events that drive weight gain during antidepressant treatment. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
C1 [Corfitsen, Henrik Thyge; Drago, Antonio] Aarhus Univ, Dept Clin Med, Psykiatrisk Forskningsenhed Vest, GI Landevej 49,1, DK-7400 Herning, Denmark.
C3 Aarhus University
RP Drago, A (corresponding author), Aarhus Univ, Dept Clin Med, Psykiatrisk Forskningsenhed Vest, GI Landevej 49,1, DK-7400 Herning, Denmark.
EM antonio.drago76@gmail.com
RI Corfitsen, Henrik/AAT-8077-2020; Drago, Antonio/O-5763-2018
OI Corfitsen, Henrik/0000-0002-7823-4427; Drago,
   Antonio/0000-0002-2529-7256
FU STAR*D Genetics project [NIMH R01-MH072802]
FX We thank researchers involved in the initial STAR*D clinical trial (NIMH
   N01-MH90003), led by director A John Rush, MD, the STAR*D Genetics
   project (NIMH R01-MH072802), led by Steven P Hamilton, MD PhD and STAR*D
   participants.
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NR 49
TC 12
Z9 13
U1 0
U2 12
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0304-3940
EI 1872-7972
J9 NEUROSCI LETT
JI Neurosci. Lett.
PD JAN 10
PY 2017
VL 637
BP 38
EP 43
DI 10.1016/j.neulet.2016.11.056
PG 6
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA EI8XA
UT WOS:000392790300007
PM 27899308
DA 2025-06-11
ER

PT J
AU Semanik, PA
   Lee, J
   Song, J
   Chang, RW
   Sohn, MW
   Ehrlich-Jones, LS
   Ainsworth, BE
   Nevitt, MM
   Kwoh, CK
   Dunlop, DD
AF Semanik, Pamela A.
   Lee, Jungwha
   Song, Jing
   Chang, Rowland W.
   Sohn, Min-Woong
   Ehrlich-Jones, Linda S.
   Ainsworth, Barbara E.
   Nevitt, Michael M.
   Kwoh, C. Kent
   Dunlop, Dorothy D.
TI Accelerometer-Monitored Sedentary Behavior and Observed Physical
   Function Loss
SO AMERICAN JOURNAL OF PUBLIC HEALTH
LA English
DT Article
ID ENERGY-EXPENDITURE; OSTEOPOROTIC FRACTURES; KNEE OSTEOARTHRITIS;
   METABOLIC SYNDROME; UNITED-STATES; RECOMMENDATIONS; TIME; DISEASE;
   HEALTH; RISK
AB Objectives. We examined whether objectively measured sedentary behavior is related to subsequent functional loss among community-dwelling adults with or at high risk for knee osteoarthritis.
   Methods. We analyzed longitudinal data (2008-2012) from 1659 Osteoarthritis Initiative participants aged 49 to 83 years in 4 cities. Baseline sedentary time was assessed by accelerometer monitoring. Functional loss (gait speed and chair stand testing) was regressed on baseline sedentary time and covariates (baseline function; socioeconomics [age, gender, race/ethnicity, income, education], health factors [obesity, depression, comorbidities, knee symptoms, knee osteoarthritis severity, prior knee injury, other lower extremity pain, smoking], and moderate-to-vigorous activity).
   Results. This cohort spent almost two thirds of their waking hours (average = 9.8 h) in sedentary behaviors. Sedentary time was significantly positively associated with subsequent functional loss in both gait speed (-1.66 ft/min decrease per 10% increment sedentary percentage waking hours) and chair stand rate (-0.75 repetitions/min decrease), controlling for covariates.
   Conclusions. Being less sedentary was related to less future decline in function, independent of time spent in moderate-to-vigorous activity. Both limiting sedentary activities and promoting physical activity in adults with knee osteoarthritis may be important in maintaining function.
C1 [Semanik, Pamela A.] Rush Univ, Coll Nursing, Chicago, IL 60612 USA.
   [Ainsworth, Barbara E.] Coll Hlth Solut, Sch Nutr & Hlth Promot, Phoenix, AZ USA.
   [Lee, Jungwha; Song, Jing; Chang, Rowland W.; Dunlop, Dorothy D.] Northwestern Univ, Feinberg Sch Med, Chicago, IL 60611 USA.
   [Sohn, Min-Woong] Univ Virginia, Sch Med, Charlottesville, VA 22908 USA.
   [Ehrlich-Jones, Linda S.] Rehabil Inst Chicago, Ctr Rehabil Outcome Res, Chicago, IL USA.
   [Nevitt, Michael M.] Univ Calif San Francisco, Coordinating Ctr, San Francisco, CA 94143 USA.
   [Kwoh, C. Kent] Univ Arizona, Med Ctr, Tucson, AZ USA.
C3 Rush University; Northwestern University; Feinberg School of Medicine;
   University of Virginia; Shirley Ryan AbilityLab; University of
   California System; University of California San Francisco; California
   Pacific Medical Center; California Pacific Medical Center Research
   Institute; University of Arizona
RP Dunlop, DD (corresponding author), Northwestern Univ, Inst Publ Hlth & Med, Ctr Healthcare Studies, Feinberg Sch Med, 633 St Clair St,20th Floor, Chicago, IL 60611 USA.
EM ddunlop@northwestern.edu
RI Ainsworth, Barbara/B-3775-2010; Sohn, Min-Woong/C-3560-2015
OI Lee, Jungwha/0000-0002-0806-0847; Chang, Rowland/0000-0001-6513-6855
FU National Institute for Arthritis and Musculoskeletal Diseases
   [R01-AR054155, R21-AR059412, P60-AR064464]; Falk Medical Trust; National
   Institutes of Health, a branch of the US Department of Health and Human
   Services [N01-AR-2-2258, N01-AR-2-2259, N01-AR-2-2260, N01-AR-2-2261,
   N01-AR-2-2262]; Merck Research Laboratories; Novartis Pharmaceuticals
   Corporation; GlaxoSmithKline; Pfizer, Inc.; Foundation for the National
   Institutes of Health
FX This study was funded in part by the National Institute for Arthritis
   and Musculoskeletal Diseases (R01-AR054155, R21-AR059412, P60-AR064464)
   and by the Falk Medical Trust. The publicly released Osteoarthritis
   Initiative data were funded through a public-private partnership
   consisting of 5 contracts (N01-AR-2-2258, N01-AR-2-2259, N01-AR-2-2260,
   N01-AR-2-2261, N01-AR-2-2262) awarded by the National Institutes of
   Health, a branch of the US Department of Health and Human Services.
   Private funding partners include Merck Research Laboratories, Novartis
   Pharmaceuticals Corporation, GlaxoSmithKline, and Pfizer, Inc. Private
   sector funding for the Osteoarthritis Initiative is managed by the
   Foundation for the National Institutes of Health. This study analyzes
   public data from the Osteoarthritis Initiative.
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NR 39
TC 63
Z9 69
U1 0
U2 16
PU AMER PUBLIC HEALTH ASSOC INC
PI WASHINGTON
PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA
SN 0090-0036
EI 1541-0048
J9 AM J PUBLIC HEALTH
JI Am. J. Public Health
PD MAR
PY 2015
VL 105
IS 3
BP 560
EP 566
DI 10.2105/AJPH.2014.302270
PG 7
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA CH5DP
UT WOS:000354055100040
PM 25602883
OA Green Published
DA 2025-06-11
ER

PT J
AU Shomaker, LB
   Gulley, LD
   Clark, ELM
   Hilkin, AM
   Pivarunas, B
   Tanofsky-Kraff, M
   Nadeau, KJ
   Barbour, LA
   Scott, SM
   Sheeder, JL
AF Shomaker, Lauren B.
   Gulley, Lauren D.
   Clark, Emma L. M.
   Hilkin, Allison M.
   Pivarunas, Bernadette
   Tanofsky-Kraff, Marian
   Nadeau, Kristen J.
   Barbour, Linda A.
   Scott, Stephen M.
   Sheeder, Jeanelle L.
TI Protocol for a pilot randomized controlled feasibility study of brief
   interpersonal psychotherapy for addressing social-emotional needs and
   preventing excess gestational weight gain in adolescents
SO PILOT AND FEASIBILITY STUDIES
LA English
DT Article
DE Interpersonal psychotherapy; Depression; Obesity; Pregnancy; Adolescence
ID BODY-MASS INDEX; PARENTING EDUCATION-PROGRAM; EATING-DISORDER
   EXAMINATION; GLUCOSE-TOLERANCE TEST; DEPRESSIVE SYMPTOMS;
   PHYSICAL-ACTIVITY; INSULIN SENSITIVITY; VISCERAL ADIPOSITY; METABOLIC
   SYNDROME; ADULT PREGNANCIES
AB BackgroundExcess gestational weight gain (GWG) in pregnant adolescents is a major public health concern. Excess GWG increases risk of pregnancy complications as well as postpartum and offspring obesity and cardiometabolic disease. Prevention interventions for pregnant adults that target lifestyle modification (i.e., healthy eating/physical activity) show insufficient effectiveness. Pregnant adolescents have distinct social-emotional needs, which may contribute to excess GWG. From an interpersonal theoretical framework, conflict and low social support increase negative emotions, which in turn promote excess GWG through mechanisms such as overeating and physical inactivity.MethodsThe current manuscript describes the design of a pilot randomized controlled feasibility trial of adolescent interpersonal psychotherapy (IPT) to address social-emotional needs and prevent excess GWG. Up to 50 pregnant, healthy adolescents 13-19y, 12-18weeks gestation are recruited from an interdisciplinary adolescent maternity hospital clinic and randomized to IPT + usual care or usual care alone. IPT involves 6 individual 60-minute sessions delivered by a trained behavioral health clinician during 12-30weeks gestation. Sessions include relationship psychoeducation, emotion identification and expression, and teaching/role-playing communication skills. Between sessions, adolescents are instructed to complete a daily journal and to have conversations to work on relationship goals. Outcomes are assessed at baseline, mid-program, post-program, and 3-months postpartum. Primary outcomes are feasibility and acceptability based upon rate of recruitment, session attendance, program acceptability ratings, and follow-up retention. Secondary outcomes are perinatal social functioning, stress, depression, and eating behaviors assessed with validated surveys and interviews; perinatal physical activity and sleep measured via accelerometer; GWG from measured weights; and at 3-months postpartum only, maternal adiposity by dual energy x-ray absorptiometry, maternal insulin sensitivity derived from 2-hour oral glucose tolerance testing, and infant adiposity by air displacement plethysmography.DiscussionThis pilot trial will address a key gap in extant understanding of excess GWG prevention for a high-risk population of adolescents. If feasible and acceptable, brief psychotherapy to address social-emotional needs should be tested for its effectiveness to address excess GWG and postpartum maternal/infant health. If effective, such an approach has potential to interrupt an adverse, intergenerational cycle of social-emotional distress, obesity, and cardiometabolic disease among young mothers and their offspring.Trial registrationClinicalTrials.gov NCT03086161, retrospectively registered
C1 [Shomaker, Lauren B.; Gulley, Lauren D.; Clark, Emma L. M.; Pivarunas, Bernadette] Colorado State Univ, Dept Human Dev & Family Studies, 1570 Campus Delivery, Ft Collins, CO 80523 USA.
   [Shomaker, Lauren B.] Colorado Sch Publ Hlth, Dept Community & Behav Hlth, Aurora, CO 80045 USA.
   [Shomaker, Lauren B.; Gulley, Lauren D.; Clark, Emma L. M.; Hilkin, Allison M.; Nadeau, Kristen J.; Scott, Stephen M.; Sheeder, Jeanelle L.] Univ Colorado, Dept Pediat, Sch Med, Aurora, CO 80045 USA.
   [Shomaker, Lauren B.; Gulley, Lauren D.; Clark, Emma L. M.; Hilkin, Allison M.; Nadeau, Kristen J.; Scott, Stephen M.; Sheeder, Jeanelle L.] Childrens Hosp Colorado, Aurora, CO 80045 USA.
   [Tanofsky-Kraff, Marian] Uniformed Serv Univ Hlth Sci, Dept Med & Clin Psychol, Bethesda, MD 20814 USA.
   [Tanofsky-Kraff, Marian] Uniformed Serv Univ Hlth Sci, Dept Med, Bethesda, MD 20814 USA.
   [Barbour, Linda A.] Univ Colorado, Dept Med, Sch Med, Aurora, CO USA.
   [Barbour, Linda A.; Scott, Stephen M.; Sheeder, Jeanelle L.] Univ Colorado, Dept Obstet & Gynecol, Sch Med, Aurora, CO USA.
C3 Colorado State University System; Colorado State University Fort
   Collins; Colorado School of Public Health; University of Colorado
   System; University of Colorado Anschutz Medical Campus; Children's
   Hospital Colorado; Uniformed Services University of the Health Sciences
   - USA; Uniformed Services University of the Health Sciences - USA;
   University of Colorado System; University of Colorado Anschutz Medical
   Campus; University of Colorado System; University of Colorado Anschutz
   Medical Campus
RP Shomaker, LB (corresponding author), Colorado State Univ, Dept Human Dev & Family Studies, 1570 Campus Delivery, Ft Collins, CO 80523 USA.; Shomaker, LB (corresponding author), Colorado Sch Publ Hlth, Dept Community & Behav Hlth, Aurora, CO 80045 USA.; Shomaker, LB (corresponding author), Univ Colorado, Dept Pediat, Sch Med, Aurora, CO 80045 USA.; Shomaker, LB (corresponding author), Childrens Hosp Colorado, Aurora, CO 80045 USA.
EM lauren.shomaker@colostate.edu
RI Sheeder, Jeanelle/D-4960-2013
OI Sheeder, Jeanelle/0000-0002-4463-3569
FU mini-grant program of the College of Health and Human Sciences at
   Colorado State University; Colorado School of Public Health; Prevention
   Research Center at Colorado State University; Colorado Clinical and
   Translational Sciences Institute - NIH/NCATS Colorado CTSA grant [UL1
   TR002535]
FX Support for this study was provided by the mini-grant program of the
   College of Health and Human Sciences at Colorado State University, a
   faculty seed grant from the Colorado School of Public Health, an
   interdisciplinary pilot grant from the Prevention Research Center at
   Colorado State University, and microgrant funding from the Colorado
   Clinical and Translational Sciences Institute (supported by NIH/NCATS
   Colorado CTSA grant UL1 TR002535). Contents are the authors' sole
   responsibility and do not necessarily represent official NIH views.
   Funders did not and will not direct the design of the study, data
   collection, analysis, or interpretation of data.
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NR 99
TC 2
Z9 2
U1 2
U2 8
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 2055-5784
J9 PILOT FEASIBILITY ST
JI Pilot Feasibility Stud.
PY 2020
VL 6
IS 1
AR 39
DI 10.1186/s40814-020-00578-1
PG 14
WC Medicine, Research & Experimental
WE Emerging Sources Citation Index (ESCI)
SC Research & Experimental Medicine
GA XN0XQ
UT WOS:000729238200039
PM 32206334
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Bae, JP
   Nelson, DR
   Boye, KS
   Mather, KJ
AF Bae, Jay P.
   Nelson, David R.
   Boye, Kristina S.
   Mather, Kieren J.
TI Prevalence of complications and comorbidities associated with obesity: a
   health insurance claims analysis
SO BMC PUBLIC HEALTH
LA English
DT Article
DE Obesity; Comorbidities; Hypertension; Dyslipidemia; Cardiovascular
   diseases
ID ADULTS; OVERWEIGHT; COHORT; RISK; TRENDS
AB BackgroundDespite the substantial burden of obesity in the United States (US), data on the comprehensive range of comorbidities in different age groups is limited. This study assessed the prevalence of various comorbidities among people diagnosed with obesity (as per ICD-10 diagnosis code) across age cohorts and compared how they differ from people without obesity.MethodsThis cross-sectional study analyzed individuals from all four regions (Midwest, Northeast, South, and West) of the US who had continuous insurance coverage from 2018 to 2020, using a large health insurance claims database (Merative (TM) MarketScan (R)). Identification of disorders relied on ICD-10 diagnosis code in patient claims and their prevalence was calculated.ResultsOf 6,935,911 individuals, people with a diagnosis of obesity accounted for 22.0%, 33.6%, and 34.4% in the 18-39 years, 40-64 years, and >= 65 years age groups, respectively. Within age strata, the mean age of people with obesity was comparable with those without obesity. Comorbidity burden was significantly higher among people with obesity, but increased with age in both obesity and non-obesity groups. Comorbidities with highest prevalence in people with obesity included: (i) hypertension (18-39 years: 29.0%, 40-64 years: 66.2%, >= 65 years: 89.4%), (ii) dyslipidemia (18-39 years: 28.1%, 40-64 years: 65.4%, >= 65 years: 88.0%), (iii) depression or anxiety (18-39 years: 44.1%, 40-64 years: 39.0%, >= 65 years: 38.9%), and (iv) prediabetes (18-39 years: 17.1%, 40-64 years: 32.2%, >= 65 years: 35.3%). Notably, increased prevalence of cardiometabolic risk factors such as hypertension and dyslipidemia began at an earlier age in people with obesity as compared with those without obesity. Ratio of prevalence between obesity and non-obesity groups was highest for the 18-39 years age group, as compared to older groups. Disorders such as obstructive sleep apnea, osteoarthritis, type 2 diabetes, metabolic dysfunction-associated steatotic liver disease, coronary heart diseases (CHD), and chronic kidney diseases also exhibited substantial burden among those with obesity.ConclusionsIn this claims study, hypertension and dyslipidemia were the leading comorbidities in people with obesity, with an increasing prevalence with age. The burden of cardiometabolic comorbidities among the younger age group suggested potential risk for early onset of CHD in later life. Understanding the range of obesity-related comorbidities seen in this claims data may encourage healthcare professionals and healthcare systems to systematically diagnose and better manage these disorders. Further research using additional data sources can offer a more accurate view of the prevalence of obesity and its impact.
C1 [Bae, Jay P.; Nelson, David R.; Boye, Kristina S.; Mather, Kieren J.] Eli Lilly & Co, Indianapolis, IN 46285 USA.
C3 Eli Lilly
RP Bae, JP (corresponding author), Eli Lilly & Co, Indianapolis, IN 46285 USA.
EM bae_jay@lilly.com
RI Mather, Kieren/ABE-4117-2020
FU Eli Lilly and Company
FX The authors would like to acknowledge Piyalee Pal and Era Seth,
   employees of Eli Lilly Services India Pvt. Ltd., for providing medical
   writing support.
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NR 38
TC 1
Z9 1
U1 4
U2 4
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2458
J9 BMC PUBLIC HEALTH
JI BMC Public Health
PD JAN 22
PY 2025
VL 25
IS 1
AR 273
DI 10.1186/s12889-024-21061-z
PG 8
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA T4M2X
UT WOS:001404761200001
PM 39844122
OA gold
DA 2025-06-11
ER

PT J
AU Cherix, A
   Poitry-Yamate, C
   Lanz, B
   Zanoletti, O
   Grosse, J
   Sandi, C
   Gruetter, R
   Cardinaux, JR
AF Cherix, Antoine
   Poitry-Yamate, Carole
   Lanz, Bernard
   Zanoletti, Olivia
   Grosse, Jocelyn
   Sandi, Carmen
   Gruetter, Rolf
   Cardinaux, Jean-Rene
TI Deletion of Crtc1 leads to hippocampal neuroenergetic impairments
   associated with depressive-like behavior
SO MOLECULAR PSYCHIATRY
LA English
DT Article
ID ANTERIOR CINGULATE CORTEX; OPEN-FIELD TEST; IN-VIVO; SOCIAL-ISOLATION;
   IMAGING BIOMARKERS; GLUCOSE-METABOLISM; INSULIN-RESISTANCE; PREFRONTAL
   CORTEX; BIPOLAR DISORDER; MR SPECTROSCOPY
AB Mood disorders (MD) are a major burden on society as their biology remains poorly understood, challenging both diagnosis and therapy. Among many observed biological dysfunctions, homeostatic dysregulation, such as metabolic syndrome (MeS), shows considerable comorbidity with MD. Recently, CREB-regulated transcription coactivator 1 (CRTC1), a regulator of brain metabolism, was proposed as a promising factor to understand this relationship. Searching for imaging biomarkers and associating them with pathophysiological mechanisms using preclinical models can provide significant insight into these complex psychiatric diseases and help the development of personalized healthcare. Here, we used neuroimaging technologies to show that deletion of Crtc1 in mice leads to an imaging fingerprint of hippocampal metabolic impairment related to depressive-like behavior. By identifying a deficiency in hippocampal glucose metabolism as the underlying molecular/physiological origin of the markers, we could assign an energy-boosting mood-stabilizing treatment, ebselen, which rescued behavior and neuroimaging markers. Finally, our results point toward the GABAergic system as a potential therapeutic target for behavioral dysfunctions related to metabolic disorders. This study provides new insights on Crtc1's and MeS's relationship to MD and establishes depression-related markers with clinical potential.
C1 [Cherix, Antoine; Lanz, Bernard; Gruetter, Rolf] Ecole Polytech Fed Lausanne EPFL, Lab Funct & Metab Imaging LIFMET, Lausanne, Switzerland.
   [Cherix, Antoine; Cardinaux, Jean-Rene] Lausanne Univ Hosp, Dept Psychiat, Ctr Psychiat Neurosci, Prilly, Switzerland.
   [Cherix, Antoine; Cardinaux, Jean-Rene] Lausanne Univ Hosp, Dept Psychiat, Serv Child & Adolescent Psychiat, Prilly, Switzerland.
   [Cherix, Antoine; Cardinaux, Jean-Rene] Univ Lausanne, Prilly, Switzerland.
   [Poitry-Yamate, Carole] Ecole Polytech Fed Lausanne EPFL, Ctr Biomed Imaging CIBM, Anim Imaging & Technol AIT, Lausanne, Switzerland.
   [Zanoletti, Olivia; Grosse, Jocelyn; Sandi, Carmen] Ecole Polytech Fed Lausanne EPFL, Brain & Mind Inst, Lab Behav Genet, Sch Life Sci, Lausanne, Switzerland.
C3 Swiss Federal Institutes of Technology Domain; Ecole Polytechnique
   Federale de Lausanne; University of Lausanne; Swiss Federal Institutes
   of Technology Domain; Ecole Polytechnique Federale de Lausanne; Swiss
   Federal Institutes of Technology Domain; Ecole Polytechnique Federale de
   Lausanne; Swiss School of Public Health (SSPH+)
RP Cherix, A (corresponding author), Ecole Polytech Fed Lausanne EPFL, Lab Funct & Metab Imaging LIFMET, Lausanne, Switzerland.; Cherix, A; Cardinaux, JR (corresponding author), Lausanne Univ Hosp, Dept Psychiat, Ctr Psychiat Neurosci, Prilly, Switzerland.; Cherix, A; Cardinaux, JR (corresponding author), Univ Lausanne, Prilly, Switzerland.
EM antoine.cherix@ndcn.ox.ac.uk; jean-rene.cardinaux@chuv.ch
RI Cardinaux, Jean-René/G-5391-2012
OI Cardinaux, Jean-Rene/0000-0001-6423-0014; Lanz,
   Bernard/0000-0001-5136-075X; Cherix, Antoine/0000-0002-4168-8273; Sandi,
   Carmen/0000-0001-7713-8321
FU University of Lausanne
FX Open access funding provided by University of Lausanne.
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J9 MOL PSYCHIATR
JI Mol. Psychiatr.
PD NOV
PY 2022
VL 27
IS 11
BP 4485
EP 4501
DI 10.1038/s41380-022-01791-5
EA OCT 2022
PG 17
WC Biochemistry & Molecular Biology; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Neurosciences & Neurology; Psychiatry
GA 9B2MM
UT WOS:000866309900006
PM 36224260
OA Green Submitted, hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Vrentzos, GE
   Paraskevas, KI
   Mikhailidis, DP
AF Vrentzos, G. E.
   Paraskevas, K. I.
   Mikhailidis, D. P.
TI Dyslipidemia as a risk factor for erectile dysfunction
SO CURRENT MEDICINAL CHEMISTRY
LA English
DT Review
DE erectile dysfunction; hyperlipidemia; statins; fibrates;
   phosphodiesterase type 5 inhibitors
ID COA REDUCTASE INHIBITOR; CORONARY-HEART-DISEASE; UNDIAGNOSED
   DIABETES-MELLITUS; 2ND PRINCETON CONSENSUS; URINARY-TRACT SYMPTOMS;
   NITRIC-OXIDE SYNTHASE; SEXUAL DYSFUNCTION; METABOLIC SYNDROME; CORPUS
   CAVERNOSUM; EXPERIMENTAL HYPERCHOLESTEROLEMIA
AB Erectile dysfunction (ED) is a common condition with a significant effect on quality of life. The prevalence of ED increases with age and other risk factors (hypertension, diabetes, smoking, coronary heart disease, dyslipidemia and depression). Nitric oxide (NO) activity is adversely affected, in penile and vascular tissue, by these risk factors. Endothelial dysfunction and a reduced generation or bioavailability of NO have emerged as major pathophysiological mechanisms in ED.
   Hyperlipidemia may impair erectile function by affecting endothelial and smooth muscle cells of the penis. Oxidized low-density lipoprotein is a causative factor for the impaired relaxation response of the corpus cavernosum. Elevated serum cholesterol and reduced high density, lipoprotein cholesterol levels are associated with an increased risk of ED. It follows that treating dyslipidemia could have a beneficial effect on ED.
   Phosphodiesterase type 5 inhibitors are now considered as first line treatment for ED. There is evidence that statins improve responses to these drugs.
   ED is considered as a warning sign of silent or early vascular disease. The use of statins may be beneficial in these patients.
C1 UCL Royal Free Hosp, Royal Free Univ Coll, Sch Med, Dept Clin Biochem, London NW3 2QG, England.
C3 University of London; University College London; UCL Medical School
RP Mikhailidis, DP (corresponding author), UCL Royal Free Hosp, Royal Free Univ Coll, Sch Med, Dept Clin Biochem, Pond St, London NW3 2QG, England.
EM mikhailidis@aol.com
RI Mikhailidis, Dimitri/A-1869-2013
OI Paraskevas, Kosmas I./0000-0001-6865-2919
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   EMIRATES
SN 0929-8673
EI 1875-533X
J9 CURR MED CHEM
JI Curr. Med. Chem.
PY 2007
VL 14
IS 16
BP 1765
EP 1770
PG 6
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Pharmacology &
   Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
GA 181BT
UT WOS:000247412500007
PM 17627514
DA 2025-06-11
ER

PT J
AU Ileri, I
   Borazan, FY
   Cavusoglu, C
   Göker, B
AF Ileri, Ibrahim
   Borazan, Funda Yildirim
   Cavusoglu, Cagatay
   Goker, Berna
TI The relationship between the severity of insomnia and falls in the
   elderly
SO PSYCHOGERIATRICS
LA English
DT Article
DE elderly; falls; insomnia; severity
ID RISK-FACTORS; SLEEP DISTURBANCES; OLDER-PEOPLE; ADULTS; INDEX;
   POPULATION; GO; ASSOCIATION; VALIDATION; SYMPTOMS
AB Background Insomnia is associated with depression, cognitive impairment, hypertension, myocardial infarction, stroke, metabolic syndrome and prostate cancer in the elderly. The aim of this study is to investigate the relationship between severity of insomnia and falls. Methods This cross-sectional study was conducted in a single geriatric outpatient clinic at a university teaching hospital. Patients with active infection, who could not complete insomnia severity index (ISI) test because of cognitive impairment and who could not perform handgrip strength and timed up and go (TUG) tests were excluded from the study. Results A total of 215 patients were included in this study. Logistic regression analysis showed that there is significant relationship between poorer TUG performance, mild insomnia, moderate insomnia, severe insomnia and falls in the elderly (odds ratio (OR) = 1.04, CI: 1.00-1.09, P = 0.041, OR = 2.43, CI: 1.22-4.85, P = 0.011, OR = 3.84, CI:1.35-10.94, P = 0.012, OR = 5.81, CI:1.00-33.72, P = 0.050). Conclusions In this study we showed that there is a relationship between the severity of insomnia and falls.
C1 [Ileri, Ibrahim; Borazan, Funda Yildirim; Cavusoglu, Cagatay; Goker, Berna] Gazi Univ, Dept Internal Med, Div Geriatr Med, Sch Med, Ankara, Turkey.
C3 Gazi University
RP Ileri, I (corresponding author), Gazi Univ Hosp Internal Med, Geriatr Med Dept, TR-06500 Ankara, Turkey.
EM ibrahimileri60@hotmail.com
RI Yıldırım Borazan, Funda/HGD-6076-2022; cavusoglu, cagatay/GSN-8505-2022
OI ileri, ibrahim/0000-0002-7237-5261
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NR 47
TC 6
Z9 7
U1 0
U2 19
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1346-3500
EI 1479-8301
J9 PSYCHOGERIATRICS
JI Psychogeriatrics
PD JAN
PY 2022
VL 22
IS 1
BP 22
EP 28
DI 10.1111/psyg.12767
EA OCT 2021
PG 7
WC Geriatrics & Gerontology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology; Psychiatry
GA XY5SQ
UT WOS:000703333500001
PM 34608721
DA 2025-06-11
ER

PT J
AU Gomes-Da-Costa, S
   Marx, W
   Corponi, F
   Anmella, G
   Murru, A
   Pons-Cabrera, MT
   Giménez-Palomo, A
   Gutiérrez-Arango, F
   Llach, CD
   Fico, G
   Kotzalidis, GD
   Verdolini, N
   Valentí, M
   Berk, M
   Vieta, E
   Pacchiarotti, I
AF Gomes-da-Costa, Susana
   Marx, Wolfgang
   Corponi, Filippo
   Anmella, Gerard
   Murru, Andrea
   Teresa Pons-Cabrera, Maria
   Gimenez-Palomo, Anna
   Gutierrez-Arango, Felipe
   Daniel Llach, Cristian
   Fico, Giovanna
   Kotzalidis, Georgios D.
   Verdolini, Norma
   Valenti, Marc
   Berk, Michael
   Vieta, Eduard
   Pacchiarotti, Isabella
TI Lithium therapy and weight change in people with bipolar disorder: A
   systematic review and meta-analysis
SO NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
LA English
DT Review
DE Lithium; Bipolar disorder; Weight gain; Mood stabilizers; Depression;
   Mania; Mood disorders; Psychiatry; Neurosciences
ID MAJOR DEPRESSIVE DISORDER; CONTROLLED 18-MONTH TRIAL; SHORT-TERM
   VENLAFAXINE; DOUBLE-BLIND; MAINTENANCE TREATMENT; I DISORDER;
   BODY-WEIGHT; METABOLIC SYNDROME; LAMOTRIGINE; MONOTHERAPY
AB Lithium remains the gold standard maintenance treatment for Bipolar Disorder (BD). However, weight gain is a side effect of increasing relevance due to its metabolic implications. We conducted a systematic review and meta-analysis aimed at summarizing evidence on the use of lithium and weight change in BD. We followed the PRISMA methodology, searching Pubmed, Scopus and Web of Science. From 1003 screened references, 20 studies were included in the systematic review and 9 included in the meta-analysis. In line with the studies included in the systematic review, the meta-analysis revealed that weight gain with lithium was not significant, noting a weight increase of 0.462 Kg (p = 0158). A shorter duration of treatment was significantly associated with more weight gain. Compared to placebo, there were no significant differences in weight gain. Weight gain was significantly lower with lithium than with active comparators. This work reveals a low impact of lithium on weight change, especially compared to some of the most widely used active comparators. Our results could impact clinical decisions.
C1 [Gomes-da-Costa, Susana; Anmella, Gerard; Murru, Andrea; Teresa Pons-Cabrera, Maria; Gimenez-Palomo, Anna; Gutierrez-Arango, Felipe; Daniel Llach, Cristian; Fico, Giovanna; Verdolini, Norma; Valenti, Marc; Vieta, Eduard; Pacchiarotti, Isabella] Univ Barcelona, Hosp Clin, Inst Neurosci, Bipolar & Depress Disorders Unit,IDIBAPS,CIBERSAM, 170 Villarroel St,12-0, Barcelona 08036, Spain.
   [Marx, Wolfgang; Berk, Michael] Deakin Univ, Sch Med, IMPACT Inst Mental & Phys Hlth & Clin Translat, Barwon Hlth, Geelong, Vic, Australia.
   [Corponi, Filippo] Univ Edinburgh, Sch Informat, Edinburgh, Midlothian, Scotland.
   [Kotzalidis, Georgios D.] Sapienza Univ Rome, St Andrea Univ Hosp, Sch Med & Psychol, Dept Neurosci Mental Hlth & Sensory Organs NESMOS, Via Grottarossa 1035-1039, I-00189 Rome, Italy.
C3 CIBER - Centro de Investigacion Biomedica en Red; CIBERSAM; University
   of Barcelona; Hospital Clinic de Barcelona; IDIBAPS; Barwon Health;
   Deakin University; University of Edinburgh; Sapienza University Rome;
   Azienda Ospedaliera Sant'Andrea
RP Vieta, E (corresponding author), Univ Barcelona, Hosp Clin, Inst Neurosci, Bipolar & Depress Disorders Unit,IDIBAPS,CIBERSAM, 170 Villarroel St,12-0, Barcelona 08036, Spain.
EM EVIETA@clinic.cat
RI Vieta, Eduard/Y-2919-2019; Verdolini, Norma/AAJ-1114-2020; Kotzalidis,
   Georgios/ABN-4996-2022; Diaz, Gerard/AAB-7311-2021; Marx,
   Wolfgang/AFO-7355-2022; Berk, Michael/AGH-9427-2022; Berk,
   Michael/M-7891-2013; Vieta, Eduard/I-6330-2013
OI Gomes da Costa, Susana/0000-0003-0383-0555; Llach Lopez,
   Cristian-Daniel/0000-0002-8630-7139; Pons-Cabrera, Maria
   Teresa/0000-0001-9063-0396; Berk, Michael/0000-0002-5554-6946; Vieta,
   Eduard/0000-0002-0548-0053; /0000-0002-2205-1189; Fico,
   Giovanna/0000-0003-1785-7126; Marx, Wolfgang/0000-0002-8556-8230; Murru,
   Andrea/0000-0001-6320-4420; Anmella, Gerard/0000-0002-6798-4054
FU Spanish Ministry of Science and Innovation [PI15/00283, PI18/00805];
   ISCIII-Subdireccion General de Evaluacion; Fondo Europeo de Desarrollo
   Regional (FEDER); Instituto de Salud Carlos III; CIBER of Mental Health
   (CIBERSAM); Secretaria d'Universitats i Recerca del Departament
   d'Economia i Coneixement [2017 SGR 1365]; CERCA Programme; Departament
   de Salut de la Generalitat de Catalunya [SLT006/17/00357]; European
   Union [754907, 945151]; Pons Bartran 2020 grant [PI046549]; NHMRC
   [1156072]; NIH; Simons Autism Foundation; Cancer Council of Victoria;
   Stanley Medical Research Foundation; Medical Benefits Fund; National
   Health and Medical Research Council; Medical Research Futures Fund;
   Beyond Blue; Rotary Health; A2 milk company; Meat and Livestock Board;
   Woolworths; Avant; Harry Windsor Foundation; H2020 Societal Challenges
   Programme [754907] Funding Source: H2020 Societal Challenges Programme
FX EV thanks the support of the Spanish Ministry of Science and Inno-vation
   (PI15/00283, PI18/00805) integrated into the Plan Nacional de I + D+I
   and co-financed by the ISCIII-Subdireccion General de Eval-uacion and
   the Fondo Europeo de Desarrollo Regional (FEDER) ; the Instituto de
   Salud Carlos III; the CIBER of Mental Health (CIBERSAM) ; the Secretaria
   d'Universitats i Recerca del Departament d'Economia i Coneixement (2017
   SGR 1365) , the CERCA Programme, and the Departament de Salut de la
   Generalitat de Catalunya for the PERIS grant SLT006/17/00357. Thanks the
   support of the European Union Horizon 2020 research and innovation
   program (EU.3.1.1. Understanding health, wellbeing and disease: Grant No
   754907 and EU.3.1.3. Treating and managing disease: Grant No 945151) .
   GA's research is supported by a Pons Bartran 2020 grant (PI046549) . MB
   is supported by a NHMRC Senior Principal Research Fellowship (1156072) ,
   and has received Grant/Research Support from the NIH, Cooperative
   Research Centre, Simons Autism Foundation, Cancer Council of Victoria,
   Stanley Medical Research Foundation, Medical Benefits Fund, National
   Health and Medical Research Council, Medical Research Futures Fund,
   Beyond Blue, Rotary Health, A2 milk company, Meat and Livestock Board,
   Woolworths, Avant and the Harry Windsor Foundation.
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NR 79
TC 31
Z9 31
U1 0
U2 10
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0149-7634
EI 1873-7528
J9 NEUROSCI BIOBEHAV R
JI Neurosci. Biobehav. Rev.
PD MAR
PY 2022
VL 134
AR 104266
DI 10.1016/j.neubiorev.2021.07.011
EA FEB 2022
PG 13
WC Behavioral Sciences; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Behavioral Sciences; Neurosciences & Neurology
GA ZJ0LM
UT WOS:000762004800009
PM 34265322
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Sun, FC
AF Sun, Fucheng
TI Frontiers and hotspots of high-intensity interval exercise in children
   and adolescents: text mining and knowledge domain visualization
SO FRONTIERS IN PHYSIOLOGY
LA English
DT Review
DE interval training; child health; CiteSpace; collaboration network
   analysis; spatial clustering; bibliometric analysis; visualization
   mapping
ID PHYSICAL-ACTIVITY; RISK-FACTORS; TRAINING INTERVENTIONS; METABOLIC
   ADAPTATIONS; INSULIN SENSITIVITY; POSTPRANDIAL HEALTH; PART I;
   OVERWEIGHT; COCITATION; CHILDHOOD
AB Background: During the past two decades, research on high-intensity interval exercise (HIIE) in children and adolescents has steadily accumulated, especially on the subthemes of improving cardiometabolic and cardiovascular health. However, there is still little scientific understanding of using scientometric analysis to establish knowledge maps. Exploring the relationship between known and new emerging ideas and their potential value has theoretical and practical implications in the context of a researcher's limited ability to read, analyze, and synthesize all published works.Objective: First, this study aims to provide extensive information on HIIE research in children and adolescents, including authors, institutions, countries, journals, and references. Second, the objective is to use co-occurrence, burst, and co-citation analyses based on hybrid node types to reveal hotspots and forecast frontiers for HIIE research in children and adolescents.Methods: Using the bibliographic data of the Web of Science Core Collection (WoSCC) as the data source, publications, authors, and journals were analyzed with the help of bibliometric methods and visualization tools such as CiteSpace, VOSviewer, Pajek, and Bibliometrix R package. Authorial, institutional, and national collaboration networks were plotted, along with research hotspots and research frontiers based on keyword bursts and document co-citations.Results: This study found that executive function, high-intensity interval training, heart rate variability, and insulin resistance are emerging research topics; high-intensity training, mental health, exercise intensity, and cardiometabolic risk factors are continual frontier research areas in the subthemes.Conclusion: Our study has three novel contributions. First, it explicitly and directly reflects the research history and current situation of the HIIE intervention strategy in children and adolescents. This approach makes it clear and easy to trace the origin and development of this strategy in specific groups of children and adolescents. Second, it analyzes the research hotspots of HIIE in the field and predicts the research frontiers and development trends, which will help researchers get a deeper understanding of HIIE and pediatric health research. Third, the findings will enable researchers to pinpoint the most influential scholars, institutions, journals, and references in the field, increasing the possibility of future collaborations between authors, institutions, and countries.
C1 [Sun, Fucheng] Nanjing Agr Univ, Fac Social Sci, Dept Phys Educ, Nanjing, Peoples R China.
C3 Nanjing Agricultural University
RP Sun, FC (corresponding author), Nanjing Agr Univ, Fac Social Sci, Dept Phys Educ, Nanjing, Peoples R China.
EM fucheng.sun@hotmail.com
RI SUN, FUCHENG/KIG-3372-2024
FU Jiangsu Province Social Science Foundation [21TYD003]; Jiangsu Province
   "14th Five-Year Plan" Key Project [T-a/2021/09]
FX The author(s) declare that financial support was received for the
   research, authorship, and/or publication of this article. This study was
   supported by the Jiangsu Province Social Science Foundation (21TYD003)
   and Jiangsu Province "14th Five-Year Plan" Key Project (T-a/2021/09).
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NR 100
TC 1
Z9 1
U1 5
U2 25
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1664-042X
J9 FRONT PHYSIOL
JI Front. Physiol.
PD MAR 6
PY 2024
VL 15
AR 1330578
DI 10.3389/fphys.2024.1330578
PG 21
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA LO0W4
UT WOS:001187636100001
PM 38510943
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Steenblock, C
   Hassanein, M
   Khan, EG
   Yaman, M
   Kamel, M
   Barbir, M
   Lorke, DE
   Rock, JA
   Everett, D
   Bejtullah, S
   Heimerer, A
   Tahirukaj, E
   Beqiri, P
   Bornstein, SR
AF Steenblock, Charlotte
   Hassanein, Mohamed
   Khan, Emran G.
   Yaman, Mohamad
   Kamel, Margrit
   Barbir, Mahmoud
   Lorke, Dietrich E.
   Rock, John A.
   Everett, Dean
   Bejtullah, Saqipi
   Heimerer, Adrian
   Tahirukaj, Ermal
   Beqiri, Petrit
   Bornstein, Stefan R.
TI Diabetes and COVID-19: Short- and Long-Term Consequences
SO HORMONE AND METABOLIC RESEARCH
LA English
DT Review
DE diabetes mellitus type 1; diabetes mellitus type 2; COVID-19; metabolic
   syndrome; long-COVID
ID RISK; MUCORMYCOSIS; EPIDEMIOLOGY; PATHOGENESIS; DEPRESSION
AB When the corona pandemic commenced more than two years ago, it was quickly recognized that people with metabolic diseases show an augmented risk of severe COVID-19 and an increased mortality compared to people without these comorbidities. Furthermore, an infection with SARS-CoV-2 has been shown to lead to an aggravation of metabolic diseases and in single cases to new-onset metabolic disorders. In addition to the increased risk for people with diabetes in the acute phase of COVID-19, this patient group also seems to be more often affected by long-COVID and to experience more long-term consequences than people without diabetes. The mechanisms behind these discrepancies between people with and without diabetes in relation to COVID-19 are not completely understood yet and will require further research and follow-up studies during the following years. In the current review, we discuss why patients with diabetes have this higher risk of developing severe COVID-19 symptoms not only in the acute phase of the disease but also in relation to long-COVID, vaccine breakthrough infections and re-infections. Furthermore, we discuss the effects of lockdown on glycemic control.
C1 [Steenblock, Charlotte; Kamel, Margrit; Tahirukaj, Ermal; Bornstein, Stefan R.] Tech Univ Dresden, Univ Hosp Carl Gustav Carus, Dept Med 3, Fetscherstr 74, D-01307 Dresden, Germany.
   [Hassanein, Mohamed] Dubai Hosp, Dept Diabet & Endocrinol, Dubai, U Arab Emirates.
   [Khan, Emran G.] Kings Coll Hosp London, Endocrinol & Diabetol, Dubai, U Arab Emirates.
   [Yaman, Mohamad] Nesmah Technol, Bldg 6, Dubai, U Arab Emirates.
   [Barbir, Mahmoud] Harefield Hosp, Dept Cardiol, Harefield, Middx, England.
   [Lorke, Dietrich E.] Khalifa Univ, Dept Anat & Cellular Biol, Abu Dhabi, U Arab Emirates.
   [Rock, John A.] Khalifa Univ, Coll Med & Hlth Sci, Abu Dhabi, U Arab Emirates.
   [Everett, Dean] Khalifa Univ, Dept Pathol & Infect Dis, Abu Dhabi, U Arab Emirates.
   [Bejtullah, Saqipi; Beqiri, Petrit] Coll Heimerer, Res Unit, Prishtina, Kosovo.
   [Heimerer, Adrian; Bornstein, Stefan R.] Kings Coll London, Fac Life Sci & Med, Sch Cardiovasc & Metab Med & Sci, London, England.
C3 Technische Universitat Dresden; Carl Gustav Carus University Hospital;
   Dubai Hospital; Royal Brompton & Harefield NHS Foundation Trust;
   Harefield Hospital; Khalifa University of Science & Technology; Khalifa
   University of Science & Technology; Khalifa University of Science &
   Technology; Heimerer Colleges; University of London; King's College
   London
RP Steenblock, C (corresponding author), Tech Univ Dresden, Univ Hosp Carl Gustav Carus, Dept Med 3, Fetscherstr 74, D-01307 Dresden, Germany.
EM Charlotte.Steenblock@uniklinikum-dresden.de
RI Steenblock, Charlotte/C-9038-2018
OI Steenblock, Charlotte/0000-0002-9635-4860
FU GWT, the Deutsche Forschungsgemeinschaft (DFG, German Research
   foundation) [314061271, TRR 205/2, 288034826, IRTG 2251]
FX We thank Martina Talke, Nitzan Bornstein, Gregor Muller and Aline
   Gunther for their contribution. The study was supported by GWT, the
   Deutsche Forschungsgemeinschaft (DFG, German Research foundation)
   project no. 314061271, TRR 205/2: "The Adrenal: Central Relay in Health
   and Disease" and project no. 288034826, IRTG 2251: "Immunological and
   Cellular Strategies in Metabolic Disease".
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NR 95
TC 37
Z9 38
U1 0
U2 8
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0018-5043
EI 1439-4286
J9 HORM METAB RES
JI Horm. Metab. Res.
PD AUG
PY 2022
VL 54
IS 08
BP 503
EP 509
DI 10.1055/a-1878-9566
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 3P8NC
UT WOS:000837790500003
PM 35724689
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Moreira, VC
   Silva, CMS
   Welker, AF
   da Silva, ICR
AF Moreira, Vanessa C.
   Silva, Calliandra M. S.
   Welker, Alexis F.
   da Silva, Izabel C. R.
TI Visceral Adipose Tissue Influence on Health Problem Development and Its
   Relationship with Serum Biochemical Parameters in Middle-Aged and Older
   Adults: A Literature Review
SO JOURNAL OF AGING RESEARCH
LA English
DT Review
ID FATTY LIVER-DISEASE; COMPUTED-TOMOGRAPHY; SKELETAL-MUSCLE; ABDOMINAL
   FAT; SARCOPENIC OBESITY; INSULIN-RESISTANCE; RISK-FACTORS;
   CARDIOVASCULAR-DISEASE; DEPRESSIVE SYMPTOMS; METABOLIC SYNDROME
AB Background. The amount of visceral adipose tissue (VAT) tends to increase with age and is associated with several health problems, such as cardiometabolic diseases, increased infections, and overall mortality. Objectives. This review provides a general assessment of how visceral adiposity correlates with the development of health problems and changes in serum biochemical parameters in middle-aged and older adults. Methods. We searched specific terms in the Virtual Health Library (VHL) databases for VAT articles published in the English language between 2009 and 2019 related to older adults. Results. The search found twenty-three publications in this period, of which nine were excluded. The publications had a population aged between 42 and 83 years and correlated the VAT area ratio with several comorbidities (such as pancreatitis, depression, cancer, and coronary heart disease) and serum biochemical parameters. Conclusion. Further research on the association between visceral obesity and the emergence of health problems and the relationship between VAT and changes in serum biochemical parameters in older individuals should deepen the understanding of this connection and develop preventive actions.
C1 [Moreira, Vanessa C.; Silva, Calliandra M. S.; Welker, Alexis F.; da Silva, Izabel C. R.] Univ Brasilia, Hlth Sci & Technol, BR-72220275 Brasilia, DF, Brazil.
C3 Universidade de Brasilia
RP Moreira, VC (corresponding author), Univ Brasilia, Hlth Sci & Technol, BR-72220275 Brasilia, DF, Brazil.
EM vanessa.moreira@ceub.edu.br; calli.de.souza@gmail.com;
   welker.af@gmail.com; belbiomedica@gmail.com
RI Welker, Alexis/B-3632-2015; moreira, vanessa/GQO-7744-2022; RODRIGUES DA
   SILVA, IZABEL CRISTINA/HLV-7294-2023
OI Silva, Izabel/0000-0002-6836-3583
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NR 71
TC 3
Z9 3
U1 0
U2 1
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2090-2204
EI 2090-2212
J9 J AGING RES
JI J. Aging Res.
PD APR 19
PY 2022
VL 2022
AR 8350527
DI 10.1155/2022/8350527
PG 13
WC Geriatrics & Gerontology
WE Emerging Sources Citation Index (ESCI)
SC Geriatrics & Gerontology
GA 1C8NM
UT WOS:000793369700001
PM 35492380
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Li, J
   Cao, DH
   Huang, Y
   Chen, ZY
   Wang, RY
   Dong, Q
   Wei, Q
   Liu, LR
AF Li, Jin
   Cao, Dehong
   Huang, Yin
   Chen, Zeyu
   Wang, Ruyi
   Dong, Qiang
   Wei, Qiang
   Liu, Liangren
TI Sleep duration and health outcomes: an umbrella review
SO SLEEP AND BREATHING
LA English
DT Review
DE Short sleep duration; Long sleep duration; Reference sleep duration;
   Appropriate sleep duration; Meta-analysis
ID BLOOD-PRESSURE; COGNITIVE DECLINE; STROKE MORTALITY; METAANALYSIS; RISK;
   CANCER; DISEASE; MELATONIN; QUALITY; ASSOCIATION
AB Purpose To collect existing evidence on the relationship between sleep duration and health outcomes. Methods A thorough search was conducted in PubMed, Web of Science, Embase, and the Cochrane Database of Systematic Reviews from inception to January, 2021. Meta-analyses of observational and interventional studies were eligible if they examined the associations between sleep duration and human health. Results In total, this umbrella review identified 69 meta-analyses with 11 outcomes for cancers and 30 outcomes for non-cancer conditions. Inappropriate sleep durations may significantly elevate the risk for cardiovascular disease (CVD), cognitive decline, coronary heart disease (CHD), depression, falls, frailty, lung cancer, metabolic syndrome (MS), and stroke. Dose-response analysis revealed that a 1-h reduction per 24 hours is associated with an increased risk by 3-11% of all-cause mortality, CHD, osteoporosis, stroke, and T2DM among short sleepers. Conversely, a 1-h increment in long sleepers is associated with a 7-17% higher risk of stroke mortality, CHD, stroke, and T2DM in adults. Conclusion Inappropriate sleep duration is a risk factor for developing non-cancer conditions. Decreasing and increasing sleep hours towards extreme sleep durations are associated with poor health outcomes.
C1 [Li, Jin; Cao, Dehong; Huang, Yin; Chen, Zeyu; Wang, Ruyi; Dong, Qiang; Wei, Qiang; Liu, Liangren] Sichuan Univ, West China Hosp, Inst Urol, Dept Urol, 37 Guoxue Alley, Chengdu 610041, Sichuan, Peoples R China.
C3 Sichuan University
RP Wei, Q; Liu, LR (corresponding author), Sichuan Univ, West China Hosp, Inst Urol, Dept Urol, 37 Guoxue Alley, Chengdu 610041, Sichuan, Peoples R China.
EM weiqiang933@126.com; liuliangren@scu.edu.cn
RI Huang, Yin/IQX-1427-2023; Wang, Ruyi/AAK-1304-2021; Chen,
   Zeyu/HGF-2358-2022
FU National Natural Science Foundation of China [81974098, 81770756];
   Program from Department of Science and Technology of Sichuan Province
   [2020YJ0054]; West China Hospital, Sichuan University [2019HXBH089];
   Health Commission of Sichuan province [20PJ036]
FX This study was funded by the National Natural Science Foundation of
   China (Grant Numbers 81974098, 81770756) and Program from Department of
   Science and Technology of Sichuan Province (Grant Number 2020YJ0054),
   Post-Doctor Research Project, West China Hospital, Sichuan University
   (Grant Number 2019HXBH089), and Health Commission of Sichuan province
   (20PJ036).
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NR 99
TC 92
Z9 92
U1 9
U2 77
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1520-9512
EI 1522-1709
J9 SLEEP BREATH
JI Sleep Breath.
PD SEP
PY 2022
VL 26
IS 3
BP 1479
EP 1501
DI 10.1007/s11325-021-02458-1
EA AUG 2021
PG 23
WC Clinical Neurology; Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Respiratory System
GA 4A4BT
UT WOS:000688386000001
PM 34435311
DA 2025-06-11
ER

PT J
AU Walker, WH
   Borniger, JC
AF Walker, William H., II
   Borniger, Jeremy C.
TI Molecular Mechanisms of Cancer-Induced Sleep Disruption
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE breast cancer; sleep; IL-6; hypocretin; orexin; leptin; EEG; autonomic
   nervous system
ID TUMOR-NECROSIS-FACTOR; INTERLEUKIN-1 RECEPTOR ANTAGONIST; DORSAL RAPHE
   NUCLEUS; BLOOD-BRAIN-BARRIER; SLOW-WAVE SLEEP; VENTROLATERAL PREOPTIC
   NUCLEUS; INHIBITS SPONTANEOUS SLEEP; LOCUS-COERULEUS NEURONS; VENTRAL
   TEGMENTAL AREA; EYE-MOVEMENT SLEEP
AB Sleep is essential for health. Indeed, poor sleep is consistently linked to the development of systemic disease, including depression, metabolic syndrome, and cognitive impairments. Further evidence has accumulated suggesting the role of sleep in cancer initiation and progression (primarily breast cancer). Indeed, patients with cancer and cancer survivors frequently experience poor sleep, manifesting as insomnia, circadian misalignment, hypersomnia, somnolence syndrome, hot flushes, and nightmares. These problems are associated with a reduction in the patients' quality of life and increased mortality. Due to the heterogeneity among cancers, treatment regimens, patient populations and lifestyle factors, the etiology of cancer-induced sleep disruption is largely unknown. Here, we discuss recent advances in understanding the pathways linking cancer and the brain and how this leads to altered sleep patterns. We describe a conceptual framework where tumors disrupt normal homeostatic processes, resulting in aberrant changes in physiology and behavior that are detrimental to health. Finally, we discuss how this knowledge can be leveraged to develop novel therapeutic approaches for cancer-associated sleep disruption, with special emphasis on host-tumor interactions.
C1 [Walker, William H., II] West Virginia Univ, Dept Neurosci, Morgantown, WV 26506 USA.
   [Borniger, Jeremy C.] Stanford Univ, Dept Psychiat & Behav Sci, Sch Med, Stanford, CA 94305 USA.
C3 West Virginia University; Stanford University
RP Borniger, JC (corresponding author), Stanford Univ, Dept Psychiat & Behav Sci, Sch Med, Stanford, CA 94305 USA.
EM William.Walker2@hsc.wvu.edu; jcbornig@stanford.edu
RI Borniger, Jeremy/AAQ-5049-2020
OI Walker II, William/0000-0001-6209-5015
FU NIMH BRAIN Initiative NRSA [F32MH115431]; NIGMS [5U54GM104942-03]; NCI
   [R01CA194024]
FX NIMH BRAIN Initiative NRSA (F32MH115431) to JCB and salary support NIGMS
   5U54GM104942-03 and NCI R01CA194024 to WHWII.
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NR 275
TC 86
Z9 91
U1 4
U2 17
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD JUN 1
PY 2019
VL 20
IS 11
AR 2780
DI 10.3390/ijms20112780
PG 32
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA IE8OX
UT WOS:000472634100174
PM 31174326
OA Green Accepted, gold, Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Smith, J
   Cline, A
   Feldman, SR
AF Smith, Jaclyn
   Cline, Abigail
   Feldman, Steven R.
TI Advances in Psoriasis
SO SOUTHERN MEDICAL JOURNAL
LA English
DT Review
DE biologics; management; new treatments; systemic medications; treatment
ID DOUBLE-BLIND; PATIENT OUTCOMES; PLAQUE PSORIASIS; BIOLOGIC AGENTS;
   TOPICAL THERAPY; UNITED-STATES; PART 1; ARTHRITIS; EFFICACY; SAFETY
AB Psoriasis treatments range from topical treatments and phototherapy to oral systemic medications and injections. Despite good control of the disease when applying appropriate treatments (according to disease severity, insurance parameters, patient preference, and patients' ability to adhere), continued advancements will allow even better symptomatic control, reduced adverse effects, and patient satisfaction. This review aims to assess traditional and new psoriasis treatments and how to apply them in clinical practice. A literature review on psoriasis treatments and clinical applications was performed using PubMed. Mild-to-moderate psoriasis treatments include topicals, localized phototherapy, and newer therapies combining two types of topicals, phototherapy with topicals, and easy-to-use foam and spray vehicles. Moderate-to-severe psoriasis therapies include monotherapy or various combinations of generalized phototherapy, oral treatments, and biologic agents, with new oral and biologic agents on the horizon. Dermatologists and primary care providers share roles in screening for associated comorbidities (including cardiovascular disorders, chronic kidney disease, Crohn disease, dyslipidemia, diabetes mellitus/insulin resistance, depression, metabolic syndrome, obesity, and psoriatic arthritis), managing patients' treatments, and reevaluating treatment needs as new therapies are approved. Continued advancements in psoriasis treatment and improvement in coordinated care will allow better overall care of patients with psoriasis.
C1 [Smith, Jaclyn; Cline, Abigail; Feldman, Steven R.] Wake Forest Sch Med, Dept Dermatol, Ctr Dermatol Res, Med Ctr Blvd, Winston Salem, NC 27157 USA.
C3 Wake Forest University
RP Smith, J (corresponding author), Wake Forest Sch Med, Dept Dermatol, Med Ctr Blvd, Winston Salem, NC 27157 USA.
EM jaclsmit@wakehealth.edu
RI Feldman, Steven/AAH-6971-2021
OI Cline, Abigail/0000-0002-4464-4727
FU Galderma Laboratories LP; 3 M; Abbott Laboratories; Abbvie; Advance
   Medical; Almirall; Amgen; Anacor; Astellas; Aventis Pharmaceuticals;
   Basilea; Baxter; BiogenIdec; Boeringer Ingelheim; Bristol-Myers Squibb;
   Caremark; Celgene; Coria/Valeant; Cosmederm; Galderma; Genentech; HanAll
   Pharmaceuticals; Informa; Janssen; Leo Pharma; Lilly; Medicis; Merck;
   Merz; Mylan; National Biological Corporation; National Psoriasis
   Foundation; Novartis; Ortho Pharmaceuticals; Pfizer; Pharmaderm;
   Photomedex; Qurient; Roche Dermatology; Stiefel/GlaxoSmithKline; Suncare
   Research; UpToDate; Valeant; Warner Chilcott
FX The Center for Dermatology Research is supported by an unrestricted
   educational grant from Galderma Laboratories LP.S.R.F. is or has been a
   consultant to, speaker for, has ongoing financial relationships with,
   and/or received research funding/stock options from 3 M, Abbott
   Laboratories, Abbvie, Advance Medical, Almirall, Amgen, Anacor,
   Astellas, Aventis Pharmaceuticals, Basilea, Baxter, BiogenIdec,
   Boeringer Ingelheim, Bristol-Myers Squibb, Caremark, Celgene,
   Coria/Valeant, Cosmederm, Galderma, Genentech, HanAll Pharmaceuticals,
   Informa, Janssen, Leo Pharma, Lilly, Medicis, Merck, Merz, Mylan,
   National Biological Corporation, National Psoriasis Foundation,
   Novartis, Ortho Pharmaceuticals, Pfizer, Pharmaderm, Photomedex,
   Qurient, Roche Dermatology, Stiefel/GlaxoSmithKline, Suncare Research,
   UpToDate, Valeant, and Warner Chilcott. He is the founder and holds
   stock in Causa Research and is the founder of and majority owner in
   www.DrScore.com. The remaining authors report no financial relationships
   or conflicts of interest.
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NR 62
TC 8
Z9 9
U1 1
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0038-4348
EI 1541-8243
J9 SOUTH MED J
JI South.Med.J.
PD JAN
PY 2017
VL 110
IS 1
BP 65
EP 75
DI 10.14423/SMJ.0000000000000596
PG 11
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA EL1KS
UT WOS:000394379900016
PM 28052180
DA 2025-06-11
ER

PT J
AU Zha, WB
   Ho, HTB
   Hu, T
   Hebert, MF
   Wang, J
AF Zha, Weibin
   Ho, Horace T. B.
   Hu, Tao
   Hebert, Mary F.
   Wang, Joanne
TI Serotonin transporter deficiency drives estrogen-dependent obesity and
   glucose intolerance
SO SCIENTIFIC REPORTS
LA English
DT Article
ID BROWN ADIPOSE-TISSUE; LONG-TERM USE; INSULIN-RESISTANCE; REUPTAKE
   INHIBITORS; METABOLIC SYNDROME; RECEPTOR-ALPHA; BODY-WEIGHT; RISK; MICE;
   ANTIDEPRESSANTS
AB Depression and use of antidepressant medications are both associated with increased risk of obesity, potentially attributed to a reduced serotonin transporter (SERT) function. However, how SERT deficiency promotes obesity is unknown. Here, we demonstrated that SERT-/- mice display abnormal fat accumulation in both white and brown adipose tissues, glucose intolerance and insulin resistance while exhibiting suppressed aromatase (Cyp19a1) expression and reduced circulating 17 beta-estradiol levels. 17 beta-estradiol replacement in SERT-/- mice reversed the obesity and glucose intolerance, supporting a role for estrogen in SERT deficiency-associated obesity and glucose intolerance. Treatment of wild type mice with paroxetine, a chemical inhibitor of SERT, also resulted in Cyp19a1 suppression, decreased circulating 17 beta-estradiol levels, abnormal fat accumulation, and glucose intolerance. Such effects were not observed in paroxetine-treated SERT-/- mice. Conversely, pregnant SERT-/- mice displayed normalized estrogen levels, markedly reduced fat accumulation, and improved glucose tolerance, which can be eliminated by an antagonist of estrogen receptor alpha (ER alpha). Together, these findings support that estrogen suppression is involved in SERT deficiency-induced obesity and glucose intolerance, and suggest approaches to restore 17 beta-estradiol levels as a novel treatment option for SERT deficiency associated obesity and metabolic abnormalities.
C1 [Zha, Weibin; Ho, Horace T. B.; Hu, Tao; Wang, Joanne] Univ Washington, Dept Pharmaceut, Seattle, WA 98195 USA.
   [Hebert, Mary F.] Univ Washington, Dept Pharm, Seattle, WA 98195 USA.
   [Hebert, Mary F.] Univ Washington, Dept Obstet & Gynecol, Seattle, WA 98195 USA.
   [Wang, Joanne] Univ Washington, Nutr Obes Res Ctr, Seattle, WA 98195 USA.
C3 University of Washington; University of Washington Seattle; University
   of Washington; University of Washington Seattle; University of
   Washington; University of Washington Seattle; University of Washington;
   University of Washington Seattle
RP Wang, J (corresponding author), Univ Washington, Dept Pharmaceut, Seattle, WA 98195 USA.; Wang, J (corresponding author), Univ Washington, Nutr Obes Res Ctr, Seattle, WA 98195 USA.
EM jowang@u.washington.edu
RI Hu, Tao/O-2570-2014
OI Hebert, Mary/0000-0002-2530-8189; Hu, Tao/0000-0002-0601-3078
FU NIH [R01 GM066233, U10 HD047892]; Elmer M. Plein Endowment Research
   Fund;  [P30 DK035816]
FX This work was supported in part by NIH grants R01 GM066233 (to J.W.),
   U10 HD047892 (to M.F.H.), and funding from the Elmer M. Plein Endowment
   Research Fund (to W.Z.). We thank Dr. Haichuan Duan, Dr. Nora Lee, and
   David Wagner (Department of Pharmaceutics, University of Washington) for
   their help in animal experiments. We are grateful to Dr. Phillip Hylemon
   (Department of Microbiology and Immunology, Virginia Commonwealth
   University) for his critical comments and helpful suggestions. We also
   thank the University of Washington Nutrition Obesity Research Center
   (supported by P30 DK035816), Pathology Histology Laboratory, and
   Pathology Digital Imaging Core Facility.
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NR 69
TC 45
Z9 51
U1 0
U2 9
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD APR 25
PY 2017
VL 7
AR 1137
DI 10.1038/s41598-017-01291-5
PG 14
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA ET2LL
UT WOS:000400104200026
PM 28442777
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Siddiqui, M
   Cooper, LA
   Appel, LJ
   Yu, AR
   Charleston, J
   Gennusa, J
   Dickerson, F
   Daumit, GL
AF Siddiqui, Mona
   Cooper, Lisa A.
   Appel, Lawrence J.
   Yu, Airong
   Charleston, Jeanne
   Gennusa, Joseph
   Dickerson, Faith
   Daumit, Gail L.
TI RECRUITMENT AND ENROLLMENT OF AFRICAN AMERICANS AND CAUCASIANS IN A
   HEALTH PROMOTION TRIAL FOR PERSONS WITH SERIOUS MENTAL ILLNESS
SO ETHNICITY & DISEASE
LA English
DT Article
DE Recruitment; African Americans; Serious Mental Illness; Cardiovascular
   Disease; Clinical Trial
ID WEIGHT-LOSS; PRIMARY-CARE; RANDOMIZED-TRIAL; CLINICAL-TRIALS; DEPRESSION
   TREATMENT; RACIAL-DISPARITIES; MINORITY PATIENTS; BLOOD-PRESSURE;
   INTERVENTIONS; HYPERTENSION
AB African Americans with serious mental illness (SMI) continue to experience inadequate representation in clinical trials. Persons with SMI, regardless of race, have an increased burden of all cardiovascular disease (CVD) risk factors including obesity, hypertension, diabetes mellitus, dyslipidemia, metabolic syndrome and tobacco smoking. Having SMI and being African American, however, is each associated with an increased risk of CVD mortality compared to the general population. There is a critical need, therefore, to adapt health promotion interventions for African Americans with SMI. We sought to examine overall recruitment into a randomized clinical trial of CVD prevention among persons with SMI, and to examine racial differences in interest, enrollment, and potential barriers to participation. Although similar levels of interest in participation were seen between African Americans and Caucasians in signing screening consent, 9.6% fewer African Americans enrolled due to inability to complete initial data collection. Further work is needed to better understand the nature of the barriers encountered by African Americans with SMI who otherwise may be interested in participating within clinical trials.
C1 [Siddiqui, Mona; Cooper, Lisa A.; Appel, Lawrence J.; Yu, Airong; Gennusa, Joseph; Daumit, Gail L.] Johns Hopkins Univ, Sch Med, Dept Gen Internal Med, Baltimore, MD 21218 USA.
   [Cooper, Lisa A.; Appel, Lawrence J.; Charleston, Jeanne; Daumit, Gail L.] Johns Hopkins Univ, Welch Ctr Prevent Epidemiol & Clin Res, Baltimore, MD 21218 USA.
   [Appel, Lawrence J.; Daumit, Gail L.] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD 21205 USA.
   [Daumit, Gail L.] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Hlth Policy & Management, Baltimore, MD 21205 USA.
   [Daumit, Gail L.] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Mental Hlth, Baltimore, MD 21205 USA.
   [Daumit, Gail L.] Johns Hopkins Univ, Sch Med, Dept Psychiat, Baltimore, MD 21218 USA.
   [Dickerson, Faith] Sheppard Pratt Hlth Syst, Towson, MD 21204 USA.
C3 Johns Hopkins University; Johns Hopkins University; Johns Hopkins
   University; Johns Hopkins Bloomberg School of Public Health; Johns
   Hopkins University; Johns Hopkins Bloomberg School of Public Health;
   Johns Hopkins University; Johns Hopkins Bloomberg School of Public
   Health; Johns Hopkins University
RP Siddiqui, M (corresponding author), Hampton House,Room 626,624 North Broadway, Baltimore, MD 21205 USA.
EM msiddiq2@jhmi.edu
RI Appel, Larry/GLT-2608-2022; Dickerson, Faith/C-8311-2019
FU National Institute of Mental Health [R01MH080964]; AHRQ NRSA Comparative
   Effectiveness Development Training Award [1T32HS019488-02]; National
   Heart, Lung, and Blood Institute [K24 HL083113, P50 HL0105187]
FX This study was funded by a grant from The National Institute of Mental
   Health (R01MH080964). Dr. Siddiqui's salary was supported by an AHRQ
   NRSA Comparative Effectiveness Development Training Award
   (1T32HS019488-02). Dr. Cooper is supported by grants from the National
   Heart, Lung, and Blood Institute (K24 HL083113 and P50 HL0105187). We
   are very appreciative of the participants and staff at the study sites
   who made this study possible.
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NR 45
TC 4
Z9 4
U1 0
U2 12
PU INT SOC HYPERTENSION BLACKS-ISHIB
PI ATLANTA
PA 100 AUBURN AVE NE STE 401, ATLANTA, GA 30303-2527 USA
SN 1049-510X
EI 1945-0826
J9 ETHNIC DIS
JI Ethn. Dis.
PD WIN
PY 2015
VL 25
IS 1
BP 72
EP 77
PG 6
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA CU7KV
UT WOS:000363717600013
PM 25812255
DA 2025-06-11
ER

PT J
AU Laraia, B
   Brownell, K
   Friebur, R
   Perera, R
   Brown, E
   Mayer, SE
   Feng, IR
   Clermont, S
   Ritchie, LD
   Epel, E
AF Laraia, Barbara
   Brownell, Kristy
   Friebur, Robin
   Perera, Rachel
   Brown, Erika
   Mayer, Stefanie E.
   Feng, Ingrid
   Clermont, Sabrina
   Ritchie, Lorrene D.
   Epel, Elissa
TI Cohort profile: the longitudinal National Growth and Health Study (NGHS)
   of black and white girls from Northern California tracking how
   behavioural and psychosocial risk factors predict cardiovascular risk
   and biological ageing in midlife and in offspring
SO BMJ OPEN
LA English
DT Article
DE EPIDEMIOLOGIC STUDIES; Health Equity; PUBLIC HEALTH; Risk Factors
ID FOLLOW-UP; FOOD INSECURITY; NHLBI GROWTH; VALIDATION; RETENTION;
   DISPARITIES; THINNESS; FACEBOOK; OBESITY; STRESS
AB PurposeThe National Heart, Lung and Blood Institute Growth and Health Study (NGHS) prospectively collected anthropometric, biospecimens, clinical, health behaviour and psychosocial measures associated with cardiovascular disease from childhood to young adulthood. The aim of the current study was to assess the impact of stress, dysregulated eating and social genomic biomarkers on cardiometabolic risk factors among the original participants now in midlife and their children.ParticipantsBeginning in 1987-1988, NGHS recruited black and white girls (age 9-10 years) from socioeconomically diverse backgrounds from from three sites: Cincinnati, Ohio; Washington, DC; and Western Contra Costa County, California (N=2379) and followed them for 10 years. The study maintained an 89% retention rate. The current study is 30 years after the start of the original study and focused on the participants of California (n=887) and their children aged 2-17 years. We re-enrolled 624 of 852 eligible participants (73%): 49.2% black and 50.8% white. The mean age was 39.5 years. Among the 645 eligible biological children, 553 were enrolled; 49% black and 51% white, with 51.5% girls and 48.5% boys. The mean age was 9.3 years.Findings to dateLongitudinal analysis of adolescent drive for thinness predicted higher scores for drive for thinness during midlife, which was indirectly associated with greater adult body mass index through adult drive for thinness. Latent trajectory modelling of adolescent growth over 10 years found that women with persistently high weight trajectory had twice the odds of having children who met the definition for obesity compared with the persistently normal group, adjusting for adult weight.Future plansNew studies on neighbourhood socioeconomic status, food insecurity and additional biomarkers of chronic stress, microbiome and accelerated ageing (ie, telomere length and epigenetic clock) are underway. We are developing a 10-year follow-up to understand changes in ageing biomarkers of the participants and their children.Trial registration numberNCT00005132.
C1 [Laraia, Barbara; Perera, Rachel] Univ Calif Berkeley, Berkeley Publ Hlth, Berkeley, CA 94720 USA.
   [Brownell, Kristy] Kaiser Permanente, Div Res, Oakland, CA USA.
   [Friebur, Robin] Outside In, Sch Based Hlth Ctr, Portland, OR USA.
   [Brown, Erika] Univ Calif Berkeley, Calif Policy Lab, Berkeley, CA USA.
   [Mayer, Stefanie E.; Epel, Elissa] Univ Calif San Francisco, Dept Psychiat, San Francisco, CA USA.
   [Feng, Ingrid] Touro Univ, Coll Osteopath Med, Vallejo, CA USA.
   [Clermont, Sabrina] Icahn Sch Med Mt Sinai, New York, NY USA.
   [Ritchie, Lorrene D.] Univ Calif Oakland, Nutr Policy Inst, Off President, Oakland, CA USA.
C3 University of California System; University of California Berkeley;
   Kaiser Permanente; University of California System; University of
   California Berkeley; University of California System; University of
   California San Francisco; Touro University California; Icahn School of
   Medicine at Mount Sinai; University of California System
RP Laraia, B (corresponding author), Univ Calif Berkeley, Berkeley Publ Hlth, Berkeley, CA 94720 USA.
EM blaraia@berkeley.edu
RI Laraia, Barbara/GXG-1829-2022; Epel, Elissa/ABI-6703-2022
FU We thank the Nutrition Policy Institute which provided consultation and
   support with historical study data. Most of all, we thank our incredible
   and devoted study participants.; National Institute on Aging
   [R01AG059677] Funding Source: NIH RePORTER
FX We thank the Nutrition Policy Institute which provided consultation and
   support with historical study data. Most of all, we thank our incredible
   and devoted study participants.
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NR 45
TC 4
Z9 4
U1 1
U2 2
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2044-6055
J9 BMJ OPEN
JI BMJ Open
PD NOV
PY 2023
VL 13
IS 11
AR e072957
DI 10.1136/bmjopen-2023-072957
PG 10
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA Y0ZU1
UT WOS:001102645200005
PM 37931968
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Lara-Guzmán, OJ
   Rivera, DA
   Corrales-Agudelo, V
   Salazar-Jaramillo, L
   Gil-Izquierdo, A
   Medina, S
   Oger, C
   Durand, T
   Galano, JM
   Escobar, JS
   Muñoz-Durango, K
   Sierra, JA
AF Lara-Guzman, Oscar J.
   Rivera, Diego A.
   Corrales-Agudelo, Vanessa
   Salazar-Jaramillo, Laura
   Gil-Izquierdo, Angel
   Medina, Sonia
   Oger, Camille
   Durand, Thierry
   Galano, Jean-Marie
   Escobar, Juan S.
   Munoz-Durango, Katalina
   Sierra, Jelver A.
TI Dietary antioxidant intake is inversely associated with 2,3-dinor
   oxylipin metabolites, the major excreted oxylipins in overweight and
   obese subjects
SO FREE RADICAL BIOLOGY AND MEDICINE
LA English
DT Article
DE Oxylipins; Dietary antioxidants; Biomarkers; Obesity; Oxidative stress;
   Inflammation
ID OXIDATIVE STRESS; CARDIOMETABOLIC RISK; GUT MICROBIOTA; ADIPOSE-TISSUE;
   FATTY-ACIDS; HUMAN URINE; POLYPHENOLS; ISOPROSTANES; MARKERS; FOOD
AB Cardiometabolic disease risk factors, including obesity, insulin resistance, high blood pressure, and dyslipidemia, are associated with elevated oxidative stress biomarkers like oxylipins. Increased adiposity by itself induces various isomers of this oxidized lipid family, while dietary polyphenols show benefits in its regulation. Previously, we showed that specific co-abundant microorganisms characterized the gut microbiota of Colombians and associated differentially with diet, lifestyle, obesity, and cardiometabolic health status, which led us to hypothesize that urinary oxylipins would reflect the intensity of oxidative metabolism linked to gut microbiota dysbiosis. Thus, we selected a convenience sample of 105 participants (age: 40.2 +/- 11.9 years, 47.6% women), grouped according to microbiota, cardiometabolic health status, and body mass index (BMI); and evaluated 33 urinary oxylipins by HPLC-QqQ-MS/MS (e.g., isoprostanes, prostaglandins, and metabolites), paired with anthropometry and blood chemistry information and dietary antioxidants estimated from a 24-h food recall. In general, oxylipins did not show differences among individuals who differed in gut microbiota. While the un-metabolized oxylipin levels were not associated with BMI, the total content of oxylipin metabolites was highest in obese and cardiometabolically abnormal subjects (e.g., insulin resistant), mainly by prostaglandin-D (2,3-dinor-11 beta-PGF(2 alpha)) and 15-F-2t-IsoPs (2,3-dinor-15-F-2t-IsoP and 2,3-dinor-15-epi-15-F-2t-IsoP) metabolites. The total polyphenol intake in this cohort was 1070 +/- 627 mg/day. After adjusting for body weight, the polyphenol intake was significantly higher in lean than overweight and showed an inverse association with dinor-oxylipin levels in principal component analysis. These results suggest that the 2,3-dinor-oxylipins could be more specific bio-markers associated with BMI than their parent oxylipins and that are sensitive to be regulated by dietary antioxidants.
C1 [Lara-Guzman, Oscar J.; Rivera, Diego A.; Corrales-Agudelo, Vanessa; Salazar-Jaramillo, Laura; Escobar, Juan S.; Munoz-Durango, Katalina; Sierra, Jelver A.] Vidarium Nutr Hlth & Wellness Res Ctr, Grp Empresarial Nutresa, Calle 8 Sur 50-67, Medellin, Colombia.
   [Gil-Izquierdo, Angel; Medina, Sonia] CEBAS CSIC, Dept Food Sci & Technol, Res Grp Qual Safety & Bioact Plant Foods, POB 164,Campus Univ Espinardo, Murcia 30100, Spain.
   [Oger, Camille; Durand, Thierry; Galano, Jean-Marie] Univ Montpellier, ENSCM, CNRS,UMR 5247, Inst Biomol Max Mousseron IBMM,Pole Chimi Balard, 1919 Route Mende, F-34093 Montpellier, France.
C3 University of Murcia; Consejo Superior de Investigaciones Cientificas
   (CSIC); CSIC - Centro de Edafologia y Biologia Aplicada del Segura
   (CEBAS); Universite de Montpellier; Ecole nationale superieure de chimie
   de Montpellier; Centre National de la Recherche Scientifique (CNRS);
   CNRS - Institute of Chemistry (INC)
RP Muñoz-Durango, K; Sierra, JA (corresponding author), Vidarium Nutr Hlth & Wellness Res Ctr, Calle 8 Sur 50-67, Medellin, Colombia.
EM jsierra@serviciosnutresa.com
RI Corrales Agudelo, Vanessa/JWA-6727-2024; Escobar, Juan/F-7234-2013;
   Lara-Guzman, Oscar Javier/A-5029-2018; Camille, OGER/JED-5281-2023;
   Sierra Restrepo, Jelver Alexander/F-4970-2013; Medina,
   Sonia/M-2479-2014; Gil-Izquierdo, Angel/B-5563-2008
OI Salazar Jaramillo, Laura/0000-0002-8490-9515; Corrales-Agudelo,
   Vanessa/0000-0002-3351-3932; Lara-Guzman, Oscar
   Javier/0000-0003-2434-6228; Camille, OGER/0000-0002-5177-5792; Sierra
   Restrepo, Jelver Alexander/0000-0001-8541-1535; Medina,
   Sonia/0000-0002-7231-6480; Gil-Izquierdo, Angel/0000-0001-7646-0386;
   Rivera, Diego/0009-0000-3051-5345
FU Colombian Ministry of science, technology, and innovation (Minciencias);
   Grupo Empresarial Nutresa;  [832-2018]
FX This work was funded by the Colombian Ministry of science, technology,
   and innovation (Minciencias) and Grupo Empresarial Nutresa with grant
   number 832-2018. The funders have not had any role in designing or
   conducting the study; in the collection, management, analysis, or
   interpretation of the data; in the preparation, review, or approval of
   the manuscript; or in the decision to submit the manuscript for
   publication.
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NR 102
TC 5
Z9 5
U1 0
U2 11
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0891-5849
EI 1873-4596
J9 FREE RADICAL BIO MED
JI Free Radic. Biol. Med.
PD SEP
PY 2022
VL 190
BP 42
EP 54
DI 10.1016/j.freeradbiomed.2022.07.023
EA AUG 2022
PG 13
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 4X2VM
UT WOS:000860705500001
PM 35933054
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Brown, RL
   Alegria, KE
   Hamlat, E
   Tomiyama, AJ
   Laraia, B
   Crimmins, EM
   Moffitt, TE
   Epel, ES
AF Brown, Ryan L.
   Alegria, Katie E.
   Hamlat, Elissa
   Tomiyama, A. Janet
   Laraia, Barbara
   Crimmins, Eileen M.
   Moffitt, Terrie E.
   Epel, Elissa S.
TI Psychosocial Disadvantage During Childhood and Midlife Health: NIMHD
   Social Epigenomics Program
SO JAMA NETWORK OPEN
LA English
DT Article
ID TO-HEIGHT RATIO; SOCIOECONOMIC-STATUS; INSULIN-RESISTANCE;
   CARDIOVASCULAR-DISEASE; CARDIOMETABOLIC RISK; WAIST CIRCUMFERENCE;
   STRESS; DISPARITIES; SUSCEPTIBILITY; ADVERSITY
AB Importance Low childhood socioeconomic status (SES) is a social hallmark of aging that contributes to adult health disparities and earlier morbidity and mortality. Childhood perceptions of stress are associated with child health outcomes and may contribute to premature biological aging into adulthood. Objective To describe the association of childhood SES and perceived stress with midlife insulin resistance and epigenetic age and to explore whether late adolescent adiposity mediates the observed associations. Design, Setting, and Participants The longitudinal cohort National Heart, Lung, and Blood Institute Growth and Health Study enrolled girls aged 10 years from January 1987 to May 1988, and followed them up to 19 years of age. Participants from Richmond, California, were recruited again at midlife in 2016 to assess insulin resistance and epigenetic age. Analyses were conducted from August 2, 2023, to March 18, 2024. A total of 433 participants were eligible and included in the analyses (specific sample sizes ranged across analyses from 303 to 391). Exposures Childhood levels of SES at 10 years of age (parental educational level and income) and perceived stress at 11 years of age. Main Outcomes and Measures The hypotheses tested were formulated after data collection. Outcomes included the homeostatic model assessment of insulin resistance (HOMA-IR) and the GrimAge and DunedinPACE epigenetic clocks. Waist circumference in late adolescence was tested as a mediator. Results Among the 433 participants, the mean (SD) age was 39.4 (1.2) years; 218 (50.3%) were Black and 215 (49.7%) were White; and 135 (31.2%) had parents with a college degree or higher. Higher parental educational level was associated with lower HOMA-IR (B = -0.22 [95% CI, -0.41 to -0.02]; P = .03), lower midlife GrimAge (B = -1.76 [95% CI, -2.85 to -0.66] years; P = .002), and slower midlife DunedinPACE (B = -0.03 [95% CI, -6.29 to -0.002]; P = .04). Childhood perceived stress was indirectly associated through late adolescent adiposity with midlife HOMA-IR (B = 0.01 [95% CI, 0.001-0.01]; P = .02) and midlife GrimAge (B = 0.02 [95% CI, 0.003-0.04] years; P = .01). Conclusions and Relevance In this longitudinal cohort study of midlife health and aging, childhood social hallmarks of aging were associated with midlife insulin resistance and epigenetic age (GrimAge and DunedinPACE). Future studies should identify malleable factors that may slow the impact of social hallmarks of aging.
C1 [Brown, Ryan L.; Alegria, Katie E.; Hamlat, Elissa; Epel, Elissa S.] Univ Calif San Francisco, Ctr Hlth & Community, 675 18th St 94107, San Francisco, CA 94115 USA.
   [Tomiyama, A. Janet] Univ Calif Los Angeles, Dept Psychol, Los Angeles, CA USA.
   [Laraia, Barbara] Univ Calif Berkeley, Sch Publ Hlth, Berkeley, CA USA.
   [Crimmins, Eileen M.] Univ Southern Calif, Leonard Davis Sch Gerontol, Los Angeles, CA USA.
   [Moffitt, Terrie E.] Duke Univ, Dept Psychol & Neurosci, Durham, NC USA.
C3 University of California System; University of California San Francisco;
   University of California System; University of California Los Angeles;
   University of California System; University of California Berkeley;
   University of Southern California; Duke University
RP Brown, RL (corresponding author), Univ Calif San Francisco, Ctr Hlth & Community, 675 18th St 94107, San Francisco, CA 94115 USA.
EM ryan.l.brown@ttu.edu
RI Epel, Elissa/ABI-6703-2022; Moffitt, Terrie/D-5295-2011; Laraia,
   Barbara/GXG-1829-2022; Brown, Ryan/GYQ-6068-2022
OI Brown, Ryan/0000-0003-2844-5928
FU Eunice Kennedy Shriver National Institute of Child Health and Human
   Development [R01HD073568]; National Heart, Lung, and Blood Institute
   [R56HL141878]; National Institute on Aging [R56AG059677, R01AG059677];
   National Institutes of Health (NIH) [R01DK128575, R01HL158555]; National
   Science Foundation [BCS2220295]; Bakar Aging Research Institute at
   University of California, San Francisco; NIH [3R24AG048024-10S1]; Lisa
   Stone Pritzker Foundation
FX This study was supported by grant R01HD073568 (Race, Stress and
   Dysregulated Eating: Maternal to Child Transmission of Obesity) from the
   Eunice Kennedy Shriver National Institute of Child Health and Human
   Development; grant R56HL141878 (Neighborhood Environments and
   Intergenerational Transmission of Cardiovascular Health) from the
   National Heart, Lung, and Blood Institute; grants R56AG059677 and
   R01AG059677 (Early Life Adversity, Cumulative Life Stress, Race, and
   Cellular Aging in Midlife Women and Offspring) from the National
   Institute on Aging, grants R01DK128575 and R01HL158555 from the National
   Institutes of Health (NIH) (Dr Tomiyama); grant BCS2220295 from the
   National Science Foundation (Dr Tomiyama); the Bakar Aging Research
   Institute at University of California, San Francisco (Dr Brown); and
   grant 3R24AG048024-10S1 from the NIH (Dr Alegria); and the Lisa Stone
   Pritzker Foundation.
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NR 52
TC 5
Z9 5
U1 2
U2 3
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 2574-3805
J9 JAMA NETW OPEN
JI JAMA Netw. Open
PD JUL 29
PY 2024
VL 7
IS 7
AR e2421841
DI 10.1001/jamanetworkopen.2024.21841
PG 12
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA A5P9W
UT WOS:001283060200010
PM 39073819
OA gold
DA 2025-06-11
ER

PT J
AU He, F
   Hua, L
   Gao, LJ
AF He, Fan
   Hua, Lu
   Gao, Lijian
TI EFFECTS OF POROSITY IN A SEEPAGE MODEL ON HEMODYNAMICS
SO JOURNAL OF MECHANICS IN MEDICINE AND BIOLOGY
LA English
DT Article; Proceedings Paper
CT International Workshop on Biological Mechanics
CY OCT 17-20, 2017
CL Guangzhou, PEOPLES R CHINA
DE Seepage; porosity; hemodynamics; outlet boundary condition
ID PULSATILE BLOOD-FLOW; BOUNDARY-CONDITION; MECHANISMS
AB In this paper, we numerically investigate the effects of porosity on hemodynamics using a seepage outlet boundary condition. The results with the porosities phi = 0: 5 and phi = 0: 6 are compared. The comparison of the results shows that there are identical pressure, velocity and wall shear stress distributions in the artery zone; however, the velocities and wall shear stresses in the microcirculation zone with phi = 0: 6 are almost as twice as those with phi = 0: 5. This work suggests that the porosity changes do not provoke variations in the artery zone, but they lead to the differences of the velocities and wall shear stresses in the microcirculation zone. The results may be the explanation of syndrome X.
C1 [He, Fan] Beijing Univ Civil Engn & Architecture, Dept Mech, Sch Sci, Beijing 100044, Peoples R China.
   [He, Fan] Beijing Univ Civil Engn & Architecture, Beijing Key Lab Funct Mat Bldg Struct & Environm, Beijing 100044, Peoples R China.
   [Hua, Lu; Gao, Lijian] Chinese Acad Med Sci, Natl Ctr Cardiovasc Dis, Key Lab Clin Trial Res Cardiovasc Drugs, Fuwai Hosp,Minist Hlth, Beijing 100037, Peoples R China.
   [Hua, Lu; Gao, Lijian] Peking Union Med Coll, Beijing 100037, Peoples R China.
C3 Beijing University of Civil Engineering & Architecture; Beijing
   University of Civil Engineering & Architecture; Chinese Academy of
   Medical Sciences - Peking Union Medical College; Fu Wai Hospital - CAMS;
   Chinese Academy of Medical Sciences - Peking Union Medical College;
   Peking Union Medical College
RP He, F (corresponding author), Beijing Univ Civil Engn & Architecture, Dept Mech, Sch Sci, Beijing 100044, Peoples R China.; He, F (corresponding author), Beijing Univ Civil Engn & Architecture, Beijing Key Lab Funct Mat Bldg Struct & Environm, Beijing 100044, Peoples R China.
EM hefan@bucea.edu.cn
FU National Natural Science Foundation of China [81401492]; Science and
   Technology Project of Beijing Municipal Commission of Education
   [KM201510016012]; Foundation of Research and Innovation Team
   [21147515602]; Academic Innovation Team of Beijing University of Civil
   Engineering and Architecture [21221214111]
FX We thank National Natural Science Foundation of China (81401492) and the
   Science and Technology Project of Beijing Municipal Commission of
   Education (KM201510016012) for financially supporting this research. The
   work is also supported by the Foundation of Research and Innovation Team
   (21147515602) and the Academic Innovation Team of Beijing University of
   Civil Engineering and Architecture (21221214111).
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NR 26
TC 2
Z9 2
U1 0
U2 11
PU WORLD SCIENTIFIC PUBL CO PTE LTD
PI SINGAPORE
PA 5 TOH TUCK LINK, SINGAPORE 596224, SINGAPORE
SN 0219-5194
EI 1793-6810
J9 J MECH MED BIOL
JI J. Mech. Med. Biol.
PD NOV
PY 2017
VL 17
IS 7
AR 1740017
DI 10.1142/S0219519417400176
PG 11
WC Biophysics; Engineering, Biomedical
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Biophysics; Engineering
GA FO3HF
UT WOS:000416714700019
DA 2025-06-11
ER

PT J
AU Barone, B
   Napolitano, L
   Abate, M
   Cirillo, L
   Reccia, P
   Passaro, F
   Turco, C
   Morra, S
   Mastrangelo, F
   Scarpato, A
   Amicuzi, U
   Morgera, V
   Romano, L
   Calace, FP
   Pandolfo, SD
   De Luca, L
   Aveta, A
   Sicignano, E
   Trivellato, M
   Spena, G
   D'Alterio, C
   Fusco, GM
   Vitale, R
   Arcaniolo, D
   Crocetto, F
AF Barone, Biagio
   Napolitano, Luigi
   Abate, Marco
   Cirillo, Luigi
   Reccia, Pasquale
   Passaro, Francesco
   Turco, Carmine
   Morra, Simone
   Mastrangelo, Francesco
   Scarpato, Antonio
   Amicuzi, Ugo
   Morgera, Vincenzo
   Romano, Lorenzo
   Calace, Francesco Paolo
   Pandolfo, Savio Domenico
   De Luca, Luigi
   Aveta, Achille
   Sicignano, Enrico
   Trivellato, Massimiliano
   Spena, Gianluca
   D'Alterio, Carlo
   Fusco, Giovanni Maria
   Vitale, Raffaele
   Arcaniolo, Davide
   Crocetto, Felice
TI The Role of Testosterone in the Elderly: What Do We Know?
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE testosterone; aging; replacement therapy; erectile dysfunction;
   metabolic syndrome; depression; hypogonadism; bone density
ID LATE-ONSET HYPOGONADISM; QUALITY-OF-LIFE; BONE-MINERAL DENSITY;
   MIDDLE-AGED MEN; URINARY-TRACT SYMPTOMS; REPLACEMENT THERAPY; OLDER MEN;
   PROSTATE-CANCER; SKELETAL-MUSCLE; SEXUAL FUNCTION
AB Testosterone is the most important hormone in male health. Aging is characterized by testosterone deficiency due to decreasing testosterone levels associated with low testicular production, genetic factors, adiposity, and illness. Low testosterone levels in men are associated with sexual dysfunction (low sexual desire, erectile dysfunction), reduced skeletal muscle mass and strength, decreased bone mineral density, increased cardiovascular risk and alterations of the glycometabolic profile. Testosterone replacement therapy (TRT) shows several therapeutic effects while maintaining a good safety profile in hypogonadal men. TRT restores normal levels of serum testosterone in men, increasing libido and energy level and producing beneficial effects on bone density, strength and muscle as well as yielding cardioprotective effects. Nevertheless, TRT could be contraindicated in men with untreated prostate cancer, although poor findings are reported in the literature. In addition, different potential side effects, such as polycythemia, cardiac events and obstructive sleep apnea, should be monitored. The aim of our review is to provide an updated background regarding the pros and cons of TRT, evaluating its role and its clinical applicability in different domains.
C1 [Barone, Biagio; Napolitano, Luigi; Abate, Marco; Cirillo, Luigi; Reccia, Pasquale; Passaro, Francesco; Turco, Carmine; Morra, Simone; Mastrangelo, Francesco; Scarpato, Antonio; Amicuzi, Ugo; Morgera, Vincenzo; Romano, Lorenzo; Calace, Francesco Paolo; Pandolfo, Savio Domenico; De Luca, Luigi; Aveta, Achille; Sicignano, Enrico; Trivellato, Massimiliano; Spena, Gianluca; D'Alterio, Carlo; Fusco, Giovanni Maria; Crocetto, Felice] Univ Naples Federico II, Dept Neurosci Sci Reprod & Odontostomatol, I-80131 Naples, Italy.
   [Vitale, Raffaele] AORN San Giuseppe Moscati, Div Urol, I-83100 Avellino, Italy.
   [Arcaniolo, Davide] Univ Campania Luigi Vanvitelli, Dept Woman Child & Gen & Specialized Surg, Urol Unit, I-80131 Naples, Italy.
C3 University of Naples Federico II; San Giuseppe Moscati Hospital;
   Universita della Campania Vanvitelli
RP Napolitano, L (corresponding author), Univ Naples Federico II, Dept Neurosci Sci Reprod & Odontostomatol, I-80131 Naples, Italy.
EM biagio193@gmail.com; nluigi89@libero.it; marcoabate5@gmail.com;
   cirilloluigi22@gmail.com; reccia.pasquale1@gmail.com;
   francescopassaro1996@gmail.com; car.turco87@gmail.com;
   simonemorra@outlook.com; f.mastrangelo91@gmail.com;
   antonioscarpato1992@gmail.com; u.amicuzi@gmail.com;
   vincemorgera87@gmail.com; loryromano@hotmail.it; fra.calace@outlook.it;
   pandolfosavio@gmail.com; luigideluca86@gmail.com;
   achille-aveta@hotmail.it; enrisici90@gmail.com;
   massimiliano.trivellato@gmail.com; spena.dr@gmail.com;
   cdalterio95@gmail.com; giom.fusco@gmail.com; r.vitale0210@gmail.com;
   davide.arcaniolo@gmail.com; felice.crocetto@unina.it
RI Pandolfo, Savio/ACO-5547-2022; Morra, Simone/HJB-1560-2022; Spena,
   Gianluca/HJH-2212-2023; Aveta, Achille/GLQ-9848-2022; Romano,
   Lorenzo/LQK-0514-2024; Napolitano, Luigi/GLU-7753-2022; Barone,
   Biagio/AAY-2704-2020
OI Napolitano, Luigi/0000-0003-2036-0356; Spena,
   Gianluca/0000-0002-6714-9315; Pandolfo, Savio
   Domenico/0000-0001-9621-3059; Cirillo, Luigi/0000-0002-1677-6765; Morra,
   Simone/0000-0001-5340-8569; Sicignano, Enrico/0000-0003-2725-8530;
   Arcaniolo, Davide/0000-0002-5282-2335; Crocetto,
   Felice/0000-0002-4315-7660
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NR 182
TC 61
Z9 64
U1 0
U2 13
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD APR
PY 2022
VL 23
IS 7
AR 3535
DI 10.3390/ijms23073535
PG 21
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Biochemistry & Molecular Biology; Chemistry
GA 0N9CQ
UT WOS:000783127900001
PM 35408895
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Fyfe, JJ
   Hamilton, DL
   Daly, RM
AF Fyfe, Jackson J.
   Hamilton, D. Lee
   Daly, Robin M.
TI Minimal-Dose Resistance Training for Improving Muscle Mass, Strength,
   and Function: A Narrative Review of Current Evidence and Practical
   Considerations
SO SPORTS MEDICINE
LA English
DT Review
ID BONE-MINERAL DENSITY; HIGH-IMPACT EXERCISE; PHYSICAL-ACTIVITY;
   OLDER-ADULTS; SKELETAL-MUSCLE; CONCURRENT STRENGTH; BLOOD-PRESSURE;
   LIGHT WALKING; BRIEF BOUTS; SARCOPENIA
AB Resistance training (RT) is the only non-pharmacological intervention known to consistently improve, and therefore offset age-related declines in, skeletal muscle mass, strength, and power. RT is also associated with various health benefits that are underappreciated compared with the perceived benefits of aerobic-based exercise. For example, RT participation is associated with reduced all-cause and cancer-related mortality and reduced incidence of cardiovascular disease, hypertension, and symptoms of both anxiety and depression. Despite these benefits, participation in RT remains low, likely due to numerous factors including time constraints, a high-perceived difficulty, and limited access to facilities and equipment. Identification of RT strategies that limit barriers to participation may increase engagement in RT and subsequently improve population health outcomes. Across the lifespan, declines in strength and power occur up to eight times faster than the loss of muscle mass, and are more strongly associated with functional impairments and risks of morbidity and mortality. Strategies to maximise healthspan should therefore arguably focus more on improving or maintaining muscle strength and power than on increasing muscle mass per se. Accumulating evidence suggests that minimal doses of RT, characterised by lower session volumes than in traditional RT guidelines, together with either (1) higher training intensities/loads performed at lower frequencies (i.e. low-volume, high-load RT) or (2) lower training intensities/loads performed at higher frequencies and with minimal-to-no equipment (i.e. resistance 'exercise snacking'), can improve strength and functional ability in younger and older adults. Such minimal-dose approaches to RT have the potential to minimise various barriers to participation, and may have positive implications for the feasibility and scalability of RT. In addition, brief but frequent minimal-dose RT approaches (i.e. resistance 'exercise snacking') may provide additional benefits for interrupting sedentary behaviour patterns associated with increased cardiometabolic risk. Compared to traditional approaches, minimal-dose RT may also limit negative affective responses, such as increased discomfort and lowered enjoyment, both of which are associated with higher training volumes and may negatively influence exercise adherence. A number of practical factors, including the selection of exercises that target major muscle groups and challenge both balance and the stabilising musculature, may influence the effectiveness of minimal-dose RT on outcomes such as improved independence and quality-of-life in older adults. This narrative review aims to summarise the evidence for minimal-dose RT as a strategy for preserving muscle strength and functional ability across the lifespan, and to discuss practical models and considerations for the application of minimal-dose RT approaches.
C1 [Fyfe, Jackson J.; Hamilton, D. Lee; Daly, Robin M.] Deakin Univ, Sch Exercise & Nutr Sci, Inst Phys Act & Nutr IPAN, Geelong, Vic, Australia.
C3 Deakin University
RP Fyfe, JJ (corresponding author), Deakin Univ, Sch Exercise & Nutr Sci, Inst Phys Act & Nutr IPAN, Geelong, Vic, Australia.
EM jackson.fyfe@deakin.edu.au
RI Daly, Robin/AAN-2353-2020; Fyfe, Jackson/J-1061-2019
OI Fyfe, Jackson/0000-0002-9541-2336
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NR 108
TC 96
Z9 100
U1 12
U2 64
PU ADIS INT LTD
PI NORTHCOTE
PA 5 THE WAREHOUSE WAY, NORTHCOTE 0627, AUCKLAND, NEW ZEALAND
SN 0112-1642
EI 1179-2035
J9 SPORTS MED
JI Sports Med.
PD MAR
PY 2022
VL 52
IS 3
BP 463
EP 479
DI 10.1007/s40279-021-01605-8
EA NOV 2021
PG 17
WC Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Sport Sciences
GA ZL1GF
UT WOS:000722473700002
PM 34822137
DA 2025-06-11
ER

PT J
AU Santoro, N
AF Santoro, Nanette
TI Understanding the menopause journey
SO CLIMACTERIC
LA English
DT Review; Early Access
DE Menopause; menopausal transition; perimenopause; hormone therapy;
   vasomotor symptoms; cardiovascular health
ID FINAL MENSTRUAL PERIOD; WOMENS HEALTH; METABOLIC-SYNDROME; MIDLIFE
   WOMEN; MULTIETHNIC COHORT; VASOMOTOR SYMPTOMS; TRANSITION; DEPRESSION;
   DURATION; HORMONES
AB The menopause experience is unique to people with ovaries who attain an age at which functioning follicles are depleted. Unlike male reproductive aging, menopause is accompanied by a definable reproductive milestone in that menstrual periods cease and the failure of follicle growth results in a large drop in circulating estrogen and no further ovarian production of progesterone. While the focus on menopause has largely been centered on this absence of hormone production, the most dynamic changes in symptoms and health markers begin before the final menstrual period, and merit attention. Vasomotor symptoms, the most common symptom of menopause and the primary symptom that drives women to seek treatment, peak in frequency and prevalence in the late menopause transition, when women are still having menstrual periods. Body composition and adverse lipoprotein and lipid changes also worsen most acutely in the late transition, and then assume a slower, age-related trajectory of change. Multiple processes that worsen across the transition restabilize after it is over. The notion that the menopause transition is an adaptive process for women has scientific merit and suggests that facilitating this adaptation and recognizing its implications may represent the next phase of progress in the field.
C1 [Santoro, Nanette] Univ Colorado, Sch Med, Dept Obstet & Gynecol, Aurora, CO 80045 USA.
C3 University of Colorado System; University of Colorado Anschutz Medical
   Campus
RP Santoro, N (corresponding author), Univ Colorado, Sch Med, Dept Obstet & Gynecol, Aurora, CO 80045 USA.
EM nanette.santoro@cuanschutz.edu
OI Santoro, Nanette/0000-0001-9096-7490; Stute, Petra/0000-0002-5591-1552
FU National Institute of Nursing Research (NINR); National Institutes of
   Health (NIH) Office of Research on Women's Health (ORWH) or NIH
FX The content of this article is solely the responsibility of the author
   and does not necessarily represent the official views of the National
   Institute on Aging (NIA), National Institute of Nursing Research (NINR),
   National Institutes of Health (NIH) Office of Research on Women's Health
   (ORWH) or NIH.
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NR 46
TC 2
Z9 2
U1 4
U2 4
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1369-7137
EI 1473-0804
J9 CLIMACTERIC
JI Climacteric
PD 2025 FEB 1
PY 2025
DI 10.1080/13697137.2024.2445303
EA FEB 2025
PG 5
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA U6P3T
UT WOS:001412985500001
PM 40044127
DA 2025-06-11
ER

PT J
AU Markova-Car, EP
   Jurisic, D
   Ilic, N
   Pavelic, SK
AF Markova-Car, Elitza P.
   Jurisic, Davor
   Ilic, Nataa
   Pavelic, Sandra Kraljevic
TI Running for time: circadian rhythms and melanoma
SO TUMOR BIOLOGY
LA English
DT Review
DE Clock genes; Circadian rhythm; Melatonin; Cancer; Melanoma
ID CLOCK GENES; DNA-DAMAGE; TUMOR-SUPPRESSOR; DEREGULATED EXPRESSION;
   EXCISION-REPAIR; DOWN-REGULATION; MESSENGER-RNA; E-BOX; SKIN; CANCER
AB Circadian timing system includes an input pathway transmitting environmental signals to a core oscillator that generates circadian signals responsible for the peripheral physiological or behavioural events. Circadian 24-h rhythms regulate diverse physiologic processes. Deregulation of these rhythms is associated with a number of pathogenic conditions including depression, diabetes, metabolic syndrome and cancer. Melanoma is a less common type of skin cancer yet more aggressive often with a lethal ending. However, little is known about circadian control in melanoma and exact functional associations between core clock genes and development of melanoma skin cancer. This paper, therefore, comprehensively analyses current literature data on the involvement of circadian clock components in melanoma development. In particular, the role of circadian rhythm deregulation is discussed in the context of DNA repair mechanisms and influence of UV radiation and artificial light exposure on cancer development. The role of arylalkylamine N-acetyltransferase (AANAT) enzyme and impact of melatonin, as a major output factor of circadian rhythm, and its protective role in melanoma are discussed in details. We hypothesise that further understanding of clock genes' involvement and circadian regulation might foster discoveries in the field of melanoma diagnostics and treatment.
C1 [Markova-Car, Elitza P.; Ilic, Nataa; Pavelic, Sandra Kraljevic] Univ Rijeka, Dept Biotechnol, Rijeka 51000, Croatia.
   [Jurisic, Davor] Univ Hosp Ctr Rijeka, Dept Plast & Reconstruct Surg, Surg Clin, Rijeka 51000, Croatia.
C3 University of Rijeka; University of Rijeka
RP Markova-Car, EP (corresponding author), Univ Rijeka, Dept Biotechnol, Radmile Matejcic 2, Rijeka 51000, Croatia.
EM elitza@biotech.uniri.hr; davor_jurisic@inet.hr; natasha_ilich@yahoo.com;
   sandrakp@biotech.uniri.hr
RI Ilic, Natasa/AAR-2491-2021; Kraljevic Pavelic, Sandra/J-3864-2012;
   Markova-Car, Elitza/R-6810-2018; Jurisic, M.D. FEBOPRAS, Ass.Prof.Ph.D.
   Davor/R-9986-2018
OI Kraljevic Pavelic, Sandra/0000-0003-0491-673X; Ilic,
   Natasa/0000-0001-5987-2805; Markova-Car, Elitza/0000-0001-6979-0731;
   Jurisic, M.D. FEBOPRAS, Ass.Prof.Ph.D. Davor/0000-0003-1948-6963
FU Croatian Ministry of Science, Education and Sports [335-0000000-3532]
FX This work was supported by the Croatian Ministry of Science, Education
   and Sports grant (335-0000000-3532).
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NR 104
TC 14
Z9 16
U1 0
U2 12
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1010-4283
EI 1423-0380
J9 TUMOR BIOL
JI Tumor Biol.
PD SEP
PY 2014
VL 35
IS 9
BP 8359
EP 8368
DI 10.1007/s13277-014-1904-2
PG 10
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA AR5ZQ
UT WOS:000343662000004
PM 24729125
DA 2025-06-11
ER

PT J
AU Sebastian, D
   Lucía, B
   Gastón, B
   Fabian, M
   Luciana, MY
   Pilar, AM
   Raquel, PN
AF Sebastian, Del Rosso
   Lucia, Baraquet
   Gaston, Bergero
   Fabian, Munoz
   Luciana, Mazzocco Yanina
   Pilar, Aoki Maria
   Raquel, Perovic Nilda
TI Associations between objectively measured physical activity, sedentary
   time, and cardiorespiratory fitness with inflammatory and oxidative
   stress markers and heart rate variability
SO JOURNAL OF PUBLIC HEALTH RESEARCH
LA English
DT Article
DE Sedentary lifestyles; cytokines; autonomic control; cardiorespiratory
   fitness; cardiometabolic risk
ID PREVENTION; INACTIVITY; OBESITY
AB Background: To assess the associations between physical activity (PA) and sedentary time (SEDT) with inflammatory and oxidative stress markers, heart rate variability (HRV) and post-exercise recovery (HRR) controlling for cardiorespiratory fitness (CRF) and potential confounders.
   Design and methods: The following data was collected from 44 participants during 2019 (age = 49.5 +/- 6.4 years, 66% women): Plasma levels of C-reactive protein (CRP) and cytokines (IL-1 beta, INF-gamma, TNF-alpha, MCP-1, IL-6, IL-8, IL-10, IL-18, IL-23); catalase (CAT) and glutathione peroxidase (GPX) activities; resting heart (HR) rate for HRV analysis, anthropometric measures, a submaximal cycling test to evaluate CRF with active recovery to assess and HRR (absolute and Delta HR), and 7-day accelerometry.
   Results: Women spent significantly more SEDT (p = 0.035), had higher inflammatory markers (IL-6 and TNF) and lower HRV indices [SDNN, LF/HF, SD2 (p > 0.05)]. Significant associations were found between SEDT and markers of inflammation [CRP, B = 0.006, p = 0.001; MCP-1, B = 0.003, p = 0.038]. HRV indices were significantly associated with inflammatory/oxidative stress markers [IL-10 (p = 0.04), GPX (p = 0.014), ln-IL 23 (p = 0.036), CAT (p = 0.026)] while HRR was positively associated with light PA [Delta 3 (B = 0.051, p = 0.043), Delta 4 (B = 0.062, p = 0.021)] and inversely related to catalase [Delta 3 (B = -54.7, p = 0.042), Delta 4 (B = -54.1, p = 0.021] and CRP [Delta 5 (B = -19.8, p = 0.033)]. Higher CRF showed lower values for TNF-alpha (p = 0.02) and IL-10 (p = 0.003) and better HRV/HRR indices [RMSSD, PNS, SampEn, SD1 (p < 0.05)].
   Conclusions: SEDT had a higher impact on inflammation and autonomic balance, independently of PA levels with differences by sex and CRF. PA appears to be more important for a better HRR. Lower HRV and HRR could be indicative of inflammatory status.
C1 [Sebastian, Del Rosso; Lucia, Baraquet; Raquel, Perovic Nilda] Univ Nacl Cordoba, Fac Ciencias Med, Ctr Invest Nutr Humana, Escuela Nutr, Edificio Escuelas 2 Piso Blvd Reforma S-N, RA-5000 Cordoba, Argentina.
   [Gaston, Bergero; Luciana, Mazzocco Yanina; Pilar, Aoki Maria] Consejo Nacl Invest Cient & Tecn, Ctr Invest Bioquim Clin & Inmunol CIBIC, Cordoba, Argentina.
   [Gaston, Bergero; Luciana, Mazzocco Yanina; Pilar, Aoki Maria] Univ Nacl Cordoba, Fac Ciencias Quim, Dept Bioquim Clin, Cordoba, Argentina.
   [Fabian, Munoz] Consejo Nacl Invest Cient & Tecn, Inst Invest Ciencias Salud INICSA, Cordoba, Argentina.
C3 National University of Cordoba; Consejo Nacional de Investigaciones
   Cientificas y Tecnicas (CONICET); National University of Cordoba;
   Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET)
RP Sebastian, D (corresponding author), Univ Nacl Cordoba, Fac Ciencias Med, Ctr Invest Nutr Humana, Escuela Nutr, Edificio Escuelas 2 Piso Blvd Reforma S-N, RA-5000 Cordoba, Argentina.
EM delrossosebastian@gmail.com
RI Aoki, Maria Pilar/JAX-6186-2023; Del Rosso, Sebastian/J-5738-2019
OI Del Rosso, Sebastian/0000-0003-2572-5887
FU Secretaria de Ciencia y Tecnologia, Universidad Nacional de Cordoba
   [45518]; Agencia Nacional de Promocion Cientifica y Tecnologica (ANPCyT)
   Fondo para la Investigacion Cientifica y Tecnologica [PICT 2015-1130];
   Consejo Nacional de Investigaciones Cientificas y Tecnicas de la
   Republica Argentina (CONICET, Argentina)
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: The
   present study was funded by Secretaria de Ciencia y Tecnologia,
   Universidad Nacional de Cordoba (grant No. 45518. PI: NRP), Agencia
   Nacional de Promocion Cientifica y Tecnologica (ANPCyT) Fondo para la
   Investigacion Cientifica y Tecnologica (PICT 2015-1130. PI: MPA). SDR
   and LB thank the Consejo Nacional de Investigaciones Cientificas y
   Tecnicas de la Republica Argentina (CONICET, Argentina) for the
   fellowships granted. MPA is a member of the scientific career from
   CONICET.
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NR 39
TC 4
Z9 4
U1 3
U2 10
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 2279-9028
EI 2279-9036
J9 J PUBLIC HEALTH RES
JI J. Public Health Res.
PD APR
PY 2022
VL 11
IS 2
AR 22799036221106580
DI 10.1177/22799036221106580
PG 12
WC Public, Environmental & Occupational Health
WE Emerging Sources Citation Index (ESCI)
SC Public, Environmental & Occupational Health
GA 3X0WP
UT WOS:000842766700001
PM 38606291
OA Green Accepted, gold
DA 2025-06-11
ER

PT J
AU Ruiz-Tovar, J
   Gonzalez, G
   Bolanos, MD
   Lopez-Torre, EM
   Fernández-Contreras, ME
   Muñoz, J
   Llavero, C
AF Ruiz-Tovar, Jaime
   Gonzalez, Gilberto
   Bolanos, Maria-de-Lourdes
   Lopez-Torre, Eva-Maria
   Fernandez-Contreras, Maria-Encarnacion
   Munoz, Jesus
   Llavero, Carolina
TI Changes in Sexual Functioning in Women with Severe Obesity After
   Bariatric Surgery: Impact of Postoperative Adherence to Mediterranean
   Diet
SO NUTRIENTS
LA English
DT Article
DE severe obesity; bariatric surgery; female sexual function index;
   Mediterranean diet; adherence; lubrication; orgasm; satisfaction; type 2
   diabetes mellitus; metabolic syndrome
ID QUALITY-OF-LIFE; PHYSICAL INACTIVITY; EXTREME OBESITY; DYSFUNCTION;
   WEIGHT; INFLAMMATION; DEPRESSION; RESOLUTION; DISORDERS; IMPROVES
AB Background: This study analyzes the effects of bariatric surgery on female sexual function, assessed using the Female Sexual Function Index (FSFI), and explores the impact of adherence to the Mediterranean diet during the postoperative period. Patients and methods: A retrospective observational study was conducted using a prospectively collected database, including heterosexual women with morbid obesity undergoing bariatric procedures. The FSFI questionnaire was applied before the intervention and 24 months after surgery. Adherence to the Mediterranean diet was evaluated using the PREDIMED questionnaire. Results: Among the 240 participants, 70.8% presented preoperative sexual dysfunction, which decreased to 20.5% two years post-surgery. Significant improvements were observed in all FSFI domains except for pain. Good adherence to the Mediterranean diet was associated with higher scores in the lubrication, orgasm, and satisfaction domains. Conclusions: Bariatric surgery significantly improves female sexual function, with the Mediterranean diet enhancing these benefits during the postoperative period. Future studies must investigate additional variables such as psychological factors, physical activity, and other lifestyle changes that may also influence sexual function.
C1 [Ruiz-Tovar, Jaime; Lopez-Torre, Eva-Maria; Munoz, Jesus] San Juan Dios Fdn, Madrid 28036, Spain.
   [Ruiz-Tovar, Jaime; Lopez-Torre, Eva-Maria; Munoz, Jesus] Comillas Pontifical Univ, San Juan Dios Sch Nursing & Phys Therapy, Hlth Sci Dept, Madrid 28036, Spain.
   [Gonzalez, Gilberto] Hosp Real San Jose, Guadalajara 19001, Mexico.
   [Bolanos, Maria-de-Lourdes] Univ Guadalajara, Ctr Univ Ciencias Biol Agr CUCBA, Neurosci Inst, Guadalajara 44600, Mexico.
   [Fernandez-Contreras, Maria-Encarnacion] Alfonso X Univ, Hlth Sci Dept, Madrid 28691, Spain.
   [Llavero, Carolina] Hosp Univ Henares, Day Hosp Unit, Madrid 28822, Spain.
C3 Comillas Pontifical University; Universidad de Guadalajara
RP Ruiz-Tovar, J (corresponding author), San Juan Dios Fdn, Madrid 28036, Spain.; Ruiz-Tovar, J (corresponding author), Comillas Pontifical Univ, San Juan Dios Sch Nursing & Phys Therapy, Hlth Sci Dept, Madrid 28036, Spain.
EM jruiztovar@gmail.com; gilpchmd@yahoo.com.mx;
   mariad.bolanosm@academicos.udg.mx; elopezt@comillas.edu;
   marifeco@externos.uax.es; jmunozm@comillas.edu;
   carolinallavero@gmail.com
OI Munoz Munoz, Jesus/0000-0002-3872-0930
CR Assimakopoulos K, 2011, OBES SURG, V21, P362, DOI 10.1007/s11695-010-0303-z
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NR 44
TC 0
Z9 0
U1 1
U2 1
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD FEB
PY 2025
VL 17
IS 4
AR 605
DI 10.3390/nu17040605
PG 13
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA Y1P5K
UT WOS:001429933400001
PM 40004934
OA gold
DA 2025-06-11
ER

PT J
AU Huang, ZR
   Shi, JY
   Liu, WH
   Wei, SS
   Zhang, ZF
AF Huang, Zheren
   Shi, Junyu
   Liu, Wenhua
   Wei, Shuangshuang
   Zhang, Zhifen
TI The influence of educational level in peri-menopause syndrome and
   quality of life among Chinese women
SO GYNECOLOGICAL ENDOCRINOLOGY
LA English
DT Article
DE Menopause; estrogens; ovary
ID METABOLIC SYNDROME; RATING-SCALE; SYMPTOMS; HEALTH; OSTEOPOROSIS;
   MENARCHE; RISK; AGE
AB Objective:To investigate the influence of education level in the peri-menopausal symptoms and quality of life (QoL) among Chinese women. Methods:We carried out a cross-sectional study of 1632 peri-menopausal women (age 40-60 y) who visited Hangzhou Women's Hospital from November 2018 to November 2019. The menopausal symptoms were evaluated by modified Kupperman index (KI). World Health Organization Quality of Life (WHOQOL-BREF) questionnaire was used to evaluate the QoL. Result:In total, 1501 women were included in the analysis. The mean age of natural menopause was 49.63 years in China. The five most frequent symptoms in menopausal women were Hot flash (75.53%), sexual problems (72.62%), insomnia (67.29%), fatigue (65.56%), and irritability (61.89%). Natural menopausal age, parity, BMI, bone mineral density, depression, skin formication, total score of KI, and the score of WHOQOL-BREF questionnaire were different in different educational background women (p < .05). Conclusions:The results of the study suggest that education level is associated with the age of natural menopause and menopausal symptoms. A high educational level is correlated with a better score of WHOQOL-BREF in peri-menopause women.
C1 [Huang, Zheren] Soochow Univ, Dept Obstet & Gynecol, Affiliated Hosp 3, Changzhou, Peoples R China.
   [Shi, Junyu] First Peoples Hosp Changzhou, Dept Obstet & Gynecol, Changzhou, Peoples R China.
   [Liu, Wenhua] Hangzhou Matern & Child Hlth Care Hosp, Dept Obstet & Gynecol, Hangzhou, Peoples R China.
   [Wei, Shuangshuang; Zhang, Zhifen] Hangzhou Womens Hosp, Dept Obstet & Gynecol, Hangzhou, Peoples R China.
C3 Soochow University - China
RP Liu, WH (corresponding author), Hangzhou Matern & Child Hlth Care Hosp, Dept Obstet & Gynecol, Hangzhou, Peoples R China.; Zhang, ZF (corresponding author), Hangzhou Womens Hosp, Dept Obstet & Gynecol, Hangzhou, Peoples R China.
EM 945368820@qq.com; zhangzf@zju.edu.cn
OI liu, wen hua/0000-0002-1531-2299
CR Banaczek Zbigniew, 2016, Wiad Lek, V69, P174
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NR 35
TC 11
Z9 13
U1 0
U2 19
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0951-3590
EI 1473-0766
J9 GYNECOL ENDOCRINOL
JI Gynecol. Endocrinol.
PD NOV 1
PY 2020
VL 36
IS 11
BP 991
EP 996
DI 10.1080/09513590.2020.1781081
EA JUN 2020
PG 6
WC Endocrinology & Metabolism; Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Obstetrics & Gynecology
GA OM9RU
UT WOS:000547329300001
PM 32573286
DA 2025-06-11
ER

PT J
AU Hansen, KF
   Sakamoto, K
   Obrietan, K
AF Hansen, Katelin F.
   Sakamoto, Kensuke
   Obrietan, Karl
TI MicroRNAs: a potential interface between the circadian clock and human
   health
SO GENOME MEDICINE
LA English
DT Review
ID SUPRACHIASMATIC NUCLEUS; TRANSCRIPTION FACTOR; METABOLIC SYNDROME;
   GENETIC-VARIANTS; BREAST-CANCER; SMALL RNAS; LONG-TERM; IN-VIVO;
   EXPRESSION; PERIOD
AB The biochemical activity of a stunning diversity of cell types and organ systems is shaped by a 24-hour (circadian) clock. This rhythmic drive to a good deal of the transcriptome (up to 15% of all coding genes) imparts circadian modulation over a wide range of physiological and behavioral processes (from cell division to cognition). Further, dysregulation of the clock has been implicated in the pathogenesis of a large and diverse array of disorders, such as hypertension, cancer and depression. Indeed, the possibility of utilizing therapeutic approaches that target clock physiology (that is, chronotherapy) has gained broad interest. However, a deeper understanding of the underlying molecular mechanisms that modulate the clock, and give rise to organ-specific clock transcriptomes, will be required to fully realize the power of chronotherapies. Recently, microRNAs have emerged as significant players in circadian clock timing, thus raising the possibility that clock-controlled microRNAs could contribute to disorders of the human circadian timing system. Here, we highlight recent work revealing a key role for microRNAs in clock physiology, and discuss potential approaches to unlocking their utility as effectors of circadian physiology and pathophysiology.
C1 [Hansen, Katelin F.; Sakamoto, Kensuke; Obrietan, Karl] Ohio State Univ, Dept Neurosci, Columbus, OH 43210 USA.
C3 University System of Ohio; Ohio State University
RP Obrietan, K (corresponding author), Ohio State Univ, Dept Neurosci, Columbus, OH 43210 USA.
EM obrietan.1@osu.edu
RI Hansen, Katelin/H-3447-2013
FU National Institutes of Health [MH62335, NS066345, NS067409]
FX This work was supported by grants MH62335, NS066345 and NS067409 from
   the National Institutes of Health.
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NR 87
TC 38
Z9 50
U1 0
U2 5
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1756-994X
J9 GENOME MED
JI Genome Med.
PY 2011
VL 3
AR 10
DI 10.1186/gm224
PG 8
WC Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Genetics & Heredity
GA V27QJ
UT WOS:000208627400010
PM 21345247
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Diflorio, A
   Jones, I
AF Diflorio, Arianna
   Jones, Ian
TI Is sex important? Gender differences in bipolar disorder
SO INTERNATIONAL REVIEW OF PSYCHIATRY
LA English
DT Article
ID AFFECTIVE PUERPERAL PSYCHOSIS; NATIONAL EPIDEMIOLOGIC SURVEY; METABOLIC
   SYNDROME; FOLLOW-UP; PSYCHIATRIC-DISORDERS; GENERAL-POPULATION; LITHIUM
   TREATMENT; MENSTRUAL-CYCLE; UNITED-STATES; I DISORDER
AB t Sex is clearly important in unipolar mood disorder with compelling evidence that depression is approximately twice as common in women than in men. In the case of bipolar disorder, however, it is widely perceived that the reported equal rate of illness in men and women reflects no important gender distinctions. In this paper we review the literature on gender differences in bipolar illness and attempt to summarize what is known and what requires further study. Despite the uncertainties that remain some conclusions can be drawn. Most studies, but not all, report an almost equal gender ratio in the prevalence of bipolar disorder but the majority of studies do report an increased risk in women of bipolar II/hypomania, rapid cycling and mixed episodes. Important gender distinctions are also found in patterns of co-morbidity. No consistent gender differences have been found in a number of variables including rates of depressive episodes, age and polarity of onset, symptoms, severity of the illness, response to treatment and suicidal behaviour. Unsurprisingly, however, perhaps the major distinction between men and women with bipolar disorder is the impact that reproductive life events, particularly childbirth, have on women with this diagnosis.</.
C1 [Diflorio, Arianna; Jones, Ian] Cardiff Univ, MRC Ctr Neuropsychiat Genet & Genom, Dept Psychol Med & Neurol, Cardiff CF14 4XN, S Glam, Wales.
C3 Cardiff University
RP Diflorio, A (corresponding author), Cardiff Univ, MRC Ctr Neuropsychiat Genet & Genom, Dept Psychol Med & Neurol, Henry Wellcome Bldg Biomed Res Wales,Acad Ave,Hea, Cardiff CF14 4XN, S Glam, Wales.
EM JonesIR1@cf.ac.uk
RI Jones, Ian/B-4925-2009
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NR 106
TC 221
Z9 252
U1 0
U2 31
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0954-0261
EI 1369-1627
J9 INT REV PSYCHIATR
JI Int. Rev. Psych.
PY 2010
VL 22
IS 5
BP 437
EP 452
DI 10.3109/09540261.2010.514601
PG 16
WC Psychiatry
WE Social Science Citation Index (SSCI)
SC Psychiatry
GA 675AM
UT WOS:000283795700004
PM 21047158
DA 2025-06-11
ER

PT J
AU Baig, S
   Rizi, EP
   Chia, C
   Shabeer, M
   Aung, N
   Loh, TP
   Magkos, F
   Vidal-Puig, A
   Seet, RCS
   Khoo, CM
   Toh, SA
AF Baig, Sonia
   Rizi, Ehsan Parvaresh
   Chia, Chelsea
   Shabeer, Muhammad
   Aung, Nweni
   Loh, Tze Ping
   Magkos, Faidon
   Vidal-Puig, Antonio
   Seet, Raymond C. S.
   Khoo, Chin Meng
   Toh, Sue-Anne
TI Genes Involved in Oxidative Stress Pathways Are Differentially Expressed
   in Circulating Mononuclear Cells Derived From Obese Insulin-Resistant
   and Lean Insulin-Sensitive Individuals Following a Single Mixed-Meal
   Challenge
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Article
DE obesity; mononuclear cells; oxidative stress; gene expression;
   macronutrients
ID ACTIVATED SIGNALING PATHWAYS; FACTOR-KAPPA-B; ADIPOSE-TISSUE; HIGH-FAT;
   GENERATION
AB Background: Oxidative stress induced by nutritional overload has been linked to the pathogenesis of insulin resistance, which is associated with metabolic syndrome, obesity, type 2 diabetes and diabetic vascular complications. Postprandial changes in expression of oxidative stress pathway genes in obese vs. lean individuals, following intake of different types of meals varying in macronutrient composition have not been characterized to date. Here we aimed to test whether/how oxidative stress responses in obese vs. lean individuals are modulated by meal composition.
   Methods: High-carbohydrate (HC), high-fat (HF), or high-protein (HP) liquid mixed meals were administered to study subjects (lean insulin-sensitive, n = 9 and obese insulin-resistant, n = 9). Plasma levels of glucose and insulin, lipid profile, urinary F-2-isoprostanes (F-2-lsoP), and expression levels of genes of oxidative stress pathways were assessed in mononuclear cells (MNC) derived from fresh peripheral blood, at baseline and up to 6-h postprandial states. Differences in these parameters were compared between insulin-sensitive/resistant groups undergoing aforementioned meal challenges.
   Results: Obese individuals exhibited increased pro-oxidant (i.e., CYBB and CYBA) and anti-oxidant (i.e., TXN RD1) gene expression in the postprandial state, compared with lean subjects, regardless of meal type (P interaction for group x time < 0.05). By contrast, lean subjects had higher expression of NCF-4 gene (pro-oxidant) after HC meal and SOD1 gene (anti-oxidant) after HC and HF meals (P interaction for group x meal < 0.05). There was an increase in postprandial level of urinary F-2-lsoP in the obese (P < 0.05) but not lean group.
   Conclusions: These findings may represent an adaptive oxidative response to mitigate increased stress induced by acute nutritional excess. Further, the results suggest an increased predisposition of obese subjects to oxidative stress. Chronic nutritional excess resulting in increases in body weight and adiposity might lead to decompensation leading to worsening insulin resistance and its sequel. Insights from this study could impact on nutritional recommendations for obese subjects at high-risk of cardiovascular diseases.
C1 [Baig, Sonia; Rizi, Ehsan Parvaresh; Shabeer, Muhammad; Aung, Nweni; Seet, Raymond C. S.; Khoo, Chin Meng; Toh, Sue-Anne] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Med, Singapore, Singapore.
   [Rizi, Ehsan Parvaresh; Seet, Raymond C. S.; Khoo, Chin Meng; Toh, Sue-Anne] Natl Univ Hlth Syst, Dept Med, Singapore, Singapore.
   [Chia, Chelsea] Univ Dublin, Trinity Coll Dublin, Dublin, Ireland.
   [Loh, Tze Ping] Natl Univ Hlth Syst, Dept Lab Med, Singapore, Singapore.
   [Magkos, Faidon] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Physiol, Singapore, Singapore.
   [Magkos, Faidon] ASTAR, SICS, Singapore, Singapore.
   [Vidal-Puig, Antonio] Univ Cambridge, Metab Res Labs, MRC MDU, Cambridge, England.
   [Toh, Sue-Anne] Duke Natl Univ Singapore, Grad Med Sch, Programme Cardiovasc & Metab Disorders, Singapore, Singapore.
   [Toh, Sue-Anne] Univ Penn, Perelman Sch Med, Philadelphia, PA 19104 USA.
   [Magkos, Faidon] Univ Copenhagen, Dept Nutr Exercise & Sports, Sect Obes Res, Copenhagen, Denmark.
C3 National University of Singapore; National University of Singapore;
   Trinity College Dublin; National University of Singapore; National
   University of Singapore; Agency for Science Technology & Research
   (A*STAR); A*STAR - Singapore Institute for Clinical Sciences (SICS);
   University of Cambridge; National University of Singapore; University of
   Pennsylvania; University of Copenhagen
RP Toh, SA (corresponding author), Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Med, Singapore, Singapore.; Toh, SA (corresponding author), Natl Univ Hlth Syst, Dept Med, Singapore, Singapore.; Toh, SA (corresponding author), Duke Natl Univ Singapore, Grad Med Sch, Programme Cardiovasc & Metab Disorders, Singapore, Singapore.; Toh, SA (corresponding author), Univ Penn, Perelman Sch Med, Philadelphia, PA 19104 USA.
EM mdcsates@nus.edu.sg
RI Seet, Raymond/KUD-7248-2024; Magkos, Faidon/CAA-9939-2022; Khoo, Chin
   Meng/AAD-8790-2022; Magkos, Faidon/B-4384-2010; Parvaresh Rizi,
   Ehsan/A-8189-2016
OI Magkos, Faidon/0000-0002-1312-7364; Seet, Raymond/0000-0001-8946-3578;
   Loh, Tze Ping/0000-0002-4272-0001; Parvaresh Rizi,
   Ehsan/0000-0002-2513-8829
FU Singapore Ministry of Health's National Medical Research Council under
   its NUHS-CG Metabolic Phenotyping Core Seed Funding [NMRC/CG/013/2013];
   NUHS-CG Metabolic in-vitro Models Core Seed Funding [NMRC/CG/013/2013];
   Clinician Scientist Award Grant [NMRC/CSA/034]; Cambridge-NUHS Seed Fund
   [NUHSRO/2012/067/Cambridge/03]; British Heart Foundation; MRC [G0600717]
   Funding Source: UKRI
FX Funding for this research is attributed to the Singapore Ministry of
   Health's National Medical Research Council under its NUHS-CG Metabolic
   Phenotyping Core Seed Funding (NMRC/CG/013/2013), NUHS-CG Metabolic
   in-vitro Models Core Seed Funding (NMRC/CG/013/2013), Clinician
   Scientist Award Grant (NMRC/CSA/034/2012), and Cambridge-NUHS Seed Fund
   (NUHSRO/2012/067/Cambridge/03). AV-P is funded by British Heart
   Foundation.
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NR 36
TC 6
Z9 6
U1 1
U2 4
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD APR 24
PY 2019
VL 10
AR 256
DI 10.3389/fendo.2019.00256
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA HU9TH
UT WOS:000465636300002
PM 31068904
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Malinská, H
   Oliyarnyk, O
   Skop, V
   Silhavy, J
   Landa, V
   Zídek, V
   Mlejnek, P
   Simáková, M
   Strnad, H
   Kazdová, L
   Pravenec, M
AF Malinska, Hana
   Oliyarnyk, Olena
   Skop, Vojtech
   Silhavy, Jan
   Landa, Vladimir
   Zidek, Vaclav
   Mlejnek, Petr
   Simakova, Miroslava
   Strnad, Hynek
   Kazdova, Ludmila
   Pravenec, Michal
TI Effects of Metformin on Tissue Oxidative and Dicarbonyl Stress in
   Transgenic Spontaneously Hypertensive Rats Expressing Human C-Reactive
   Protein
SO PLOS ONE
LA English
DT Article
ID FALSE DISCOVERY RATE; METHYLGLYOXAL; GLYCATION; INFLAMMATION; METABOLISM
AB Inflammation and oxidative and dicarbonyl stress play important roles in the pathogenesis of type 2 diabetes. Metformin is the first-line drug of choice for the treatment of type 2 diabetes because it effectively suppresses gluconeogenesis in the liver. However, its "pleiotropic" effects remain controversial. In the current study, we tested the effects of metformin on inflammation, oxidative and dicarbonyl stress in an animal model of inflammation and metabolic syndrome, using spontaneously hypertensive rats that transgenically express human C-reactive protein (SHR-CRP). We treated 8-month-old male transgenic SHR-CRP rats with metformin (5 mg/kg/day) mixed as part of a standard diet for 4 weeks. A corresponding untreated control group of male transgenic SHR-CRP rats were fed a standard diet without metformin. In a similar fashion, we studied a group of nontransgenic SHR treated with metformin and an untreated group of nontransgenic SHR controls. In each group, we studied 6 animals. Parameters of glucose and lipid metabolism and oxidative and dicarbonyl stress were measured using standard methods. Gene expression profiles were determined using Affymetrix GeneChip Arrays. Statistical significance was evaluated by two-way ANOVA. In the SHR-CRP transgenic strain, we found that metformin treatment decreased circulating levels of inflammatory response marker IL-6, TNF alpha and MCP-1 while levels of human CRP remained unchanged. Metformin significantly reduced oxidative stress (levels of conjugated dienes and TBARS) and dicarbonyl stress (levels of methylglyoxal) in left ventricles, but not in kidneys. No significant effects of metformin on oxidative and dicarbonyl stress were observed in SHR controls. In addition, metformin treatment reduced adipose tissue lipolysis associated with human CRP. Possible molecular mechanisms of metformin action-studied by gene expression profiling in the liver-revealed deregulated genes from inflammatory and insulin signaling, AMP-activated protein kinase (AMPK) signaling and gluconeogenesis pathways. It can be concluded that in the presence of high levels of human CRP, metformin protects against inflammation and oxidative and dicarbonyl stress in the heart, but not in the kidney. Accordingly, these cardioprotective effects of metformin might be especially effective in diabetic patients with high levels of CRP.
C1 [Malinska, Hana; Oliyarnyk, Olena; Skop, Vojtech; Kazdova, Ludmila] Inst Clin & Expt Med, Ctr Med Expt, Prague, Czech Republic.
   [Silhavy, Jan; Landa, Vladimir; Zidek, Vaclav; Mlejnek, Petr; Simakova, Miroslava; Pravenec, Michal] Acad Sci Czech Republ, Inst Physiol, Prague, Czech Republic.
   [Strnad, Hynek] Acad Sci Czech Republ, Inst Mol Genet, Prague, Czech Republic.
C3 Institute for Clinical & Experimental Medicine (IKEM); Czech Academy of
   Sciences; Institute of Physiology of the Czech Academy of Sciences;
   Czech Academy of Sciences; Institute of Molecular Genetics of the Czech
   Academy of Sciences
RP Pravenec, M (corresponding author), Acad Sci Czech Republ, Inst Physiol, Prague, Czech Republic.
EM pravenec@biomed.cas.cz
RI Simakova, Miroslava/R-5367-2019; Strnad, Hynek/B-7361-2008; Oliyarnyk,
   Olena/Q-6380-2019; Silhavy, Jan/B-5292-2014; Mlejnek, Petr/C-2305-2012;
   Pravenec, Michal/B-1666-2012; Skop, Vojtech/LBI-2231-2024
OI Mlejnek, Petr/0000-0002-4218-8983; Pravenec, Michal/0000-0001-9197-5871;
   Simakova, Miroslava/0000-0003-1468-5832; Oliyarnyk,
   Olena/0000-0002-4912-6187; Skop, Vojtech/0000-0002-4685-4429
FU Czech Science Foundation [14-36804G]; Ministry of Education, Youth and
   Sports of the Czech Republic within the ERC CZ program [LL1204];
   Ministry of Health of the Czech Republic [NT 14325-3/2013]; European
   Regional Development Fund (ERDF), Operational Program Prague -
   Competitiveness (OPPC) Biomodels [CZ.2.16/3.1.00/24017]; MH CZ-DRO
   ("Institute for Clinical and Experimental Medicine-IKEM") [IN 00023001]
FX This work was supported by grants 14-36804G from the Czech Science
   Foundation, LL1204 (within the ERC CZ program) from the Ministry of
   Education, Youth and Sports of the Czech Republic and grant NT
   14325-3/2013 from the Ministry of Health of the Czech Republic and
   supported by the European Regional Development Fund (ERDF), Operational
   Program Prague - Competitiveness (OPPC) Biomodels CZ.2.16/3.1.00/24017
   project for MP. LK was supported by MH CZ-DRO ("Institute for Clinical
   and Experimental Medicine-IKEM, IN 00023001"). The funders had no role
   in study design, data collection and analysis, decision to publish, or
   preparation of the manuscript.
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NR 27
TC 20
Z9 20
U1 0
U2 8
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAR 10
PY 2016
VL 11
IS 3
AR e0150924
DI 10.1371/journal.pone.0150924
PG 14
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA DG3TL
UT WOS:000371993000080
PM 26963617
OA gold, Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Sedzikowska, A
   Szablewski, L
AF Sedzikowska, Aleksandra
   Szablewski, Leszek
TI Human Gut Microbiota in Health and Selected Cancers
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE gut microbiota; modulators of gut microbiota; dysbiosis; cancers;
   anticancer therapy
ID CHAIN FATTY-ACIDS; INTESTINAL MICROBIOTA; FUSOBACTERIUM-NUCLEATUM;
   PANCREATIC-CANCER; LUNG-CANCER; HELICOBACTER-PYLORI; CANDIDA-ALBICANS;
   ORAL MICROBIOME; INTRAEPITHELIAL NEOPLASIA; HEPATOCELLULAR-CARCINOMA
AB The majority of the epithelial surfaces of our body, and the digestive tract, respiratory and urogenital systems, are colonized by a vast number of bacteria, archaea, fungi, protozoans, and viruses. These microbiota, particularly those of the intestines, play an important, beneficial role in digestion, metabolism, and the synthesis of vitamins. Their metabolites stimulate cytokine production by the human host, which are used against potential pathogens. The composition of the microbiota is influenced by several internal and external factors, including diet, age, disease, and lifestyle. Such changes, called dysbiosis, may be involved in the development of various conditions, such as metabolic diseases, including metabolic syndrome, type 2 diabetes mellitus, Hashimoto's thyroidis and Graves' disease; they can also play a role in nervous system disturbances, such as multiple sclerosis, Alzheimer's disease, Parkinson's disease, and depression. An association has also been found between gut microbiota dysbiosis and cancer. Our health is closely associated with the state of our microbiota, and their homeostasis. The aim of this review is to describe the associations between human gut microbiota and cancer, and examine the potential role of gut microbiota in anticancer therapy.
C1 [Sedzikowska, Aleksandra; Szablewski, Leszek] Med Univ Warsaw, Chair & Dept Gen Biol & Parasitol, Ul Chalubinskiego 5, PL-02004 Warsaw, Poland.
C3 Medical University of Warsaw
RP Szablewski, L (corresponding author), Med Univ Warsaw, Chair & Dept Gen Biol & Parasitol, Ul Chalubinskiego 5, PL-02004 Warsaw, Poland.
EM aleksandra.sedzikowska@wum.edu.pl; leszek.szablewski@wum.edu.pl
RI Sędzikowska, Aleksandra/M-7749-2018
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NR 408
TC 35
Z9 38
U1 5
U2 53
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD DEC
PY 2021
VL 22
IS 24
AR 13440
DI 10.3390/ijms222413440
PG 40
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA YB5BF
UT WOS:000739027000001
PM 34948234
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Sung-Chan, P
   Sung, YW
   Zhao, X
   Brownson, RC
AF Sung-Chan, P.
   Sung, Y. W.
   Zhao, X.
   Brownson, R. C.
TI Family-based models for childhood-obesity intervention: a systematic
   review of randomized controlled trials
SO OBESITY REVIEWS
LA English
DT Review
DE Behavioural therapy; diet; family therapy; family-based intervention;
   obesity; overweight; physical activity; youth
ID WEIGHT-LOSS PROGRAM; OVERWEIGHT CHILDREN; METABOLIC SYNDROME; EXCLUSIVE
   AGENTS; YOUNG ADULTHOOD; PARENTS; HEALTH; MANAGEMENT; PREVENTION;
   DEPRESSION
AB Effective interventions are needed to address the growing epidemic of childhood obesity. In the past 35 years, family-based approach has gradually developed as a preferred intervention. This review aimed to examine the methodological rigour and treatment effectiveness of family-based interventions according to intervention types and theoretical orientations. A total of 15 randomized controlled trials (RCTs) of family-based lifestyle interventions for children and adolescents aged 219 years were included. The adapted Methodological Quality Rating Scales (MQRS) and a four-grade qualitative scoring scheme were adopted to evaluate the methodological rigour and the effectiveness of treatment, respectively. The average MQRS score was 7.93 out of 14 points. Ten of the 15 RCTs had well aligned their research questions with appropriate research methods. The overall short-term outcome of the15 RCTs were satisfactory with an average score of 3.1. Family-based interventions rooted in behaviour theory achieved better results than those theoretically connected to family systems theory in terms of treatment effectiveness. Results suggest future studies to improve the methodological design and continue to explore the potential of the family systems approach.
C1 [Sung-Chan, P.] Hong Kong Polytech Univ, Dept Appl Social Sci, Kowloon, Hong Kong, Peoples R China.
   [Sung, Y. W.] Chinese Univ Hong Kong, Hong Kong Inst Asian Pacific Studies, Shatin, Hong Kong, Peoples R China.
   [Zhao, X.] Tongji Univ, Tongji Med Sch, Shanghai 200092, Peoples R China.
   [Brownson, R. C.] Washington Univ, George Warren Brown Sch Social Work, Prevent Res Ctr St Louis, Univ Sch Med,Dept Surg, St Louis, MO 63130 USA.
   [Brownson, R. C.] Washington Univ, George Warren Brown Sch Social Work, Prevent Res Ctr St Louis, Univ Sch Med,Alvin J Siteman Canc Ctr, St Louis, MO 63130 USA.
C3 Hong Kong Polytechnic University; Chinese University of Hong Kong;
   Tongji University; Washington University (WUSTL); Siteman Cancer Center;
   Washington University (WUSTL)
RP Sung-Chan, P (corresponding author), Hong Kong Polytech Univ, Dept Appl Social Sci, Kowloon, Hong Kong, Peoples R China.
EM Pauline.Sung@inet.polyu.edu.hk
RI Brownson, Ross/AEA-4811-2022
FU Hong Kong Research Grant Council [PolyU 5454/08H]; Fulbright Research
   Grant
FX This review was supported in part by PolyU 5454/08H from the Hong Kong
   Research Grant Council and the Fulbright Research Grant (2011-12). The
   authors are grateful to the institutional support from Dean Eddie
   Lawlor, Brown School of Social Work, Washington University in St Louis;
   constructive comments on the manuscript from Angel Lai and Ernest
   Gonzales; and research assistance from Wei Chang and Xiao-xiao Hao.
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NR 48
TC 121
Z9 151
U1 1
U2 100
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1467-7881
EI 1467-789X
J9 OBES REV
JI Obes. Rev.
PD APR
PY 2013
VL 14
IS 4
BP 265
EP 278
DI 10.1111/obr.12000
PG 14
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism
GA 108DH
UT WOS:000316271200001
PM 23136914
DA 2025-06-11
ER

PT J
AU Widaman, AM
   Witbracht, MG
   Forester, SM
   Laugero, KD
   Keim, NL
AF Widaman, Adrianne M.
   Witbracht, Megan G.
   Forester, Shavawn M.
   Laugero, Kevin D.
   Keim, Nancy L.
TI Chronic Stress Is Associated with Indicators of Diet Quality in Habitual
   Breakfast Skippers
SO JOURNAL OF THE ACADEMY OF NUTRITION AND DIETETICS
LA English
DT Article
DE Breakfast skipping; Stress; Healthy Eating Index; Food intake;
   Night-time eating
ID ENERGY-BALANCE; FOOD-INTAKE; METABOLIC SYNDROME; AMERICAN ADULTS;
   YOUNG-ADULTS; HEALTH; CONSUMPTION; ADEQUACY; INSULIN; INDEX
AB Background Previous studies suggest skipping breakfast is associated with lower diet quality, but possible reasons underlying this relationship are not clear.
   Objective Our aim was to determine the relationship between chronic stress and variations in diet quality in the context of breakfast eating or breakfast skipping.
   Design Based on morning eating habits, 40 breakfast eaters and 35 breakfast skippers participated in a cross-sectional study. Diet assessment was based on unannounced 24-hour recalls.
   Participants/setting Women, ages 18 to 45 years; with a body mass index (calculated as kg/m(2)) <40 were recruited in the greater Sacramento, CA, area between 2009 and 2013. Only women who consistently ate or skipped breakfast were enrolled.
   Main outcome measures Compliance with the 2010 Dietary Guidelines for Americans was measured using the Healthy Eating Index 2010 (HEI-2010). Stress and executive function were evaluated with validated questionnaires and a computer-based task, respectively.
   Statistical analyses performed Diet characteristics of breakfast eating and breakfast skipping were evaluated as nutrient densities (amounts per 1,000 kcal) and compared using a one-way analysis of covariance, with body mass index as covariate. Diet and stress variable associations were assessed using Pearson correlations.
   Results Despite no observed differences in daily energy intake between breakfast skipping and breakfast eating, overall diet quality (P=0.001), whole grains (P=0.002), fruit (P=0.002), empty calories (P=0.050), fiber (P=0.001), calcium (P=0.001), potassium (P=0.033), and folate (P=0.013) intakes were higher in breakfast eating. In the evening, breakfast skipping consumed more added sugars (P=0.012) and saturated fat (P=0.006). In breakfast skipping, reported stress was associated with empty calories (r=-0.39; P=0.027) and evening intake of added sugars (r=0.501: P=0.005). These relationships were not observed in breakfast eating.
   Conclusions Breakfast skippers were less likely to meet the Dietary Guidelines for Americans and consumed more empty calories at night. Chronic stress was related to evening eating choices and overall empty calories in the diet of breakfast skippers, whereas breakfast eaters' dietary intake did not appear to be affected by chronic stress.
C1 [Widaman, Adrianne M.] Univ Calif Davis, Dept Nutr, Davis, CA 95616 USA.
   [Widaman, Adrianne M.; Witbracht, Megan G.] Univ Calif Davis, Davis, CA 95616 USA.
   [Witbracht, Megan G.] Univ Calif Irvine, Mind Res Unit, Irvine, CA USA.
   [Forester, Shavawn M.] Tahoe Forest Hosp, Truckee, CA USA.
   [Laugero, Kevin D.; Keim, Nancy L.] ARS, USDA, Western Human Nutr Res Ctr, 430 W Hlth Sci Dr, Davis, CA 95616 USA.
C3 University of California System; University of California Davis;
   University of California System; University of California Davis;
   University of California System; University of California Irvine; United
   States Department of Agriculture (USDA)
RP Keim, NL (corresponding author), ARS, USDA, Western Human Nutr Res Ctr, 430 W Hlth Sci Dr, Davis, CA 95616 USA.
EM nancy.keim@ars.usda.gov
OI Widaman, Adrianne/0000-0003-2586-8888; Forester,
   Shavawn/0000-0002-7411-4882
FU ARS CRIS Projects [5306-51530-019-00D, 2032-51530-002-00D]; National
   Research Initiative Grant from the US Department of Agriculture's
   National Institute of Food and Agriculture, Human Nutrition and Obesity
   Program-31.5 [2009-35215-05364]
FX Project supported by the National Research Initiative Grant
   #2009-35215-05364 from the US Department of Agriculture's National
   Institute of Food and Agriculture, Human Nutrition and Obesity
   Program-31.5 and ARS CRIS Projects 5306-51530-019-00D and
   2032-51530-002-00D. The US Department of Agriculture is an equal
   opportunity provider and employer.
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NR 48
TC 21
Z9 24
U1 1
U2 21
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 2212-2672
EI 2212-2680
J9 J ACAD NUTR DIET
JI J. Acad. Nutr. Diet.
PD NOV
PY 2016
VL 116
IS 11
BP 1776
EP 1784
DI 10.1016/j.jand.2016.03.016
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA EB2OZ
UT WOS:000387203000007
PM 27161025
DA 2025-06-11
ER

PT J
AU Martins, LB
   Tibaes, JRB
   Berk, M
   Teixeira, AL
AF Martins, Lais Bhering
   Braga Tibaes, Jenneffer Rayane
   Berk, Michael
   Teixeira, Antonio Lucio
TI Diabetes and mood disorders: shared mechanisms and therapeutic
   opportunities
SO INTERNATIONAL JOURNAL OF PSYCHIATRY IN CLINICAL PRACTICE
LA English
DT Review
DE Diabetes mellitus; mood disorders; major depression; bipolar disorder;
   antidepressants; hypoglycemic agents
ID PIOGLITAZONE ADJUNCTIVE THERAPY; MAJOR DEPRESSIVE DISORDER; BRAIN
   INSULIN-RESISTANCE; DOUBLE-BLIND; BIPOLAR DISORDER; INTRANASAL INSULIN;
   GLYCEMIC CONTROL; CONTROLLED-TRIAL; ANTIDEPRESSANT MEDICATION; METABOLIC
   SYNDROME
AB Objective The objective of this manuscript is to provide a comprehensive and critical overview of the current evidence on the association between Diabetes mellitus (DM) and mood disorders [i.e., Major depressive disorder (MDD) and bipolar disorder (BD)], and therapeutic opportunities. Methods We searched in MEDLINE (via Ovid) for placebo-controlled clinical trials published in the last 20 years that assessed drug repurposing approaches for the treatment of DM or mood disorders. Results We found seven studies that aimed to verify the effects of antidepressants in patients diagnosed with DM, and eight studies that tested the effect of antidiabetic drugs in patients diagnosed with MDD or BD. Most studies published in the last two decades did not report a positive effect of antidepressants on glycemic control in patients with DM. On the other hand, antidiabetic drugs seem to have a positive effect on the treatment of MDD and BD. Conclusions While effect of antidepressants on glycemic control in patients with DM is still controversial, the use of antidiabetic drugs may be a promising strategy for patients with MDD or BD. Prospective studies are still needed.
C1 [Martins, Lais Bhering; Teixeira, Antonio Lucio] Univ Texas Hlth Sci Ctr Houston, Dept Psychiat & Behav Sci, Houston, TX 77030 USA.
   [Martins, Lais Bhering; Braga Tibaes, Jenneffer Rayane] Univ Fed Minas Gerais, Escola Enfermagem, Dept Nutr, Belo Horizonte, MG, Brazil.
   [Braga Tibaes, Jenneffer Rayane] Univ Alberta, Div Human Nutr, Dept Agr Food & Nutr Sci, Edmonton, AB, Canada.
   [Berk, Michael] Deakin Univ, IMPACT Inst Mental & Phys Hlth & Clin Translat, Geelong, Vic, Australia.
   [Berk, Michael] Florey Inst Neurosci & Mental Hlth, Ctr Youth Mental Hlth, Natl Ctr Excellence Youth Mental Hlth, Orygen, Parkville, Vic, Australia.
   [Berk, Michael] Univ Melbourne, Dept Psychiat, Melbourne, Vic, Australia.
   [Teixeira, Antonio Lucio] Inst Ensino & Pesquisa, Belo Horizonte, MG, Brazil.
C3 University of Texas System; University of Texas Health Science Center
   Houston; Baylor College of Medicine; Baylor College Medical Hospital;
   Universidade Federal de Minas Gerais; University of Alberta; Deakin
   University; Florey Institute of Neuroscience & Mental Health; Orygen,
   The National Centre of Excellence in Youth Mental Health; University of
   Melbourne
RP Martins, LB (corresponding author), UT Hlth Houston, Dept Psychiat & Behav Sci, 1941 East Rd, Houston, TX 77054 USA.
EM Lais.BheringMartins@uth.tmc.edu
RI Teixeira, Antonio/N-3315-2014; Braga Tibaes, Jenneffer
   Rayane/GYR-2855-2022; Berk, Michael/AGH-9427-2022; Berk,
   Michael/M-7891-2013
OI Teixeira, Antonio Lucio/0000-0002-9621-5422; Bhering Martins,
   Lais/0000-0002-9814-8649; Berk, Michael/0000-0002-5554-6946; Braga
   Tibaes, Jenneffer Rayane/0000-0002-4032-2560
FU UTHealth Houston Department of Psychiatry and Behavioral Sciences; CNPq;
   UTHealth; TARCC; NHMRC Senior Principal Research Fellowship [1156072];
   Alberta Diabetes Institute Graduate Studentship
FX The Neuropsychiatry Program is partly funded by the UTHealth Houston
   Department of Psychiatry and Behavioral Sciences. ALT is funded by CNPq,
   UTHealth and TARCC. MB is supported by a NHMRC Senior Principal Research
   Fellowship [1156072]. JRBT is supported by the Alberta Diabetes
   Institute Graduate Studentship.
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   Zhao ZX, 2016, J AFFECT DISORDERS, V202, P120, DOI 10.1016/j.jad.2016.05.059
NR 109
TC 16
Z9 16
U1 0
U2 1
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1365-1501
EI 1471-1788
J9 INT J PSYCHIAT CLIN
JI Int. J. Psychiat. Clin.
PD JUN 1
PY 2022
VL 26
IS 2
BP 183
EP 195
DI 10.1080/13651501.2021.1957117
EA JUL 2021
PG 13
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychiatry
GA 4D6HQ
UT WOS:000681119400001
PM 34348557
DA 2025-06-11
ER

PT J
AU Weghuber, D
   Barrientos-Pérez, M
   Kovarenko, M
AF Weghuber, Daniel
   Barrientos-Perez, Margarita
   Kovarenko, Margarita
TI Youth-Onset Type 2 Diabetes Manifestations in other Specialties: Its
   Many Disguises
SO ANNALS OF NUTRITION AND METABOLISM
LA English
DT Review
DE Youth-onset type 2 diabetes; Pediatrics; Dermatology; Gynecology;
   Hepatology
ID EPITHELIUM-DERIVED FACTOR; QUALITY-OF-LIFE; OBESE ADOLESCENTS;
   ACANTHOSIS NIGRICANS; YOUNG-ADULTS; CHILDREN; MELLITUS; RISK; CHILDHOOD;
   ASSOCIATION
AB Background: Youth-onset type 2 diabetes (T2D) is increasing in many countries, creating large personal and societal burdens. While many primary health-care professionals (HCPs) are aware of the classic symptoms of T2D, there are several other manifestations that could indicate its presence. Summary: This narrative review summarizes information on these symptoms and indicators, focusing on those less well known. The classic symptoms and comorbidities include frequent urination, excessive thirst, metabolic syndrome, and obesity. In addition to these, the presence of dermatological (e.g., acanthosis nigricans, granuloma annulare, necrobiosis lipoidica diabeticorum, and scleredema), gynecological (e.g., polycystic ovary syndrome, oligomenorrhea, and vulvovaginitis), hepatological (e.g., nonalcoholic fatty liver disease), and psychiatric diseases (e.g., psychosis, depression, and autism) could indicate that a patient has T2D or is at increased risk of T2D. Other less well-known indicators include abnormal blood tests (e.g., oxidized lipids, inflammation markers, hepatokines, and adipokines), prescriptions for antipsychotic medications or statins, and disrupted sleep patterns. Key Message: Due to the diversity of T2D manifestations in young people, primary HCPs need to remain alert to its possible presence. (c) 2019 S. Karger AG, Basel
C1 [Weghuber, Daniel] Paracelsus Med Sch, Dept Pediat, Strubergasse 22, AT-5020 Salzburg, Austria.
   [Barrientos-Perez, Margarita] Angeles Hosp Puebla, Serv Endocrinol Pediat, Puebla, Mexico.
   [Kovarenko, Margarita] Novosibirsk Med Univ, Dept Pediat, Novosibirsk, Russia.
RP Weghuber, D (corresponding author), Paracelsus Med Sch, Dept Pediat, Strubergasse 22, AT-5020 Salzburg, Austria.
EM d.weghuber@salk.at
RI Kovarenko, Margarita/ABD-6475-2020; Weghuber, Daniel/AAN-1422-2020;
   barrientos, margarita/Q-9342-2019
OI Barrientos Perez, Margarita/0000-0002-7089-7576; Kovarenko,
   Margarita/0000-0002-5012-0364
FU Novo Nordisk
FX Novo Nordisk funded the medical writing support for this review but,
   other than reviewing for medical accuracy, had no input into this
   manuscript.
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NR 69
TC 5
Z9 5
U1 0
U2 4
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0250-6807
EI 1421-9697
J9 ANN NUTR METAB
JI Ann. Nutr. Metab.
PY 2019
VL 74
IS 4
BP 339
EP 347
DI 10.1159/000500234
PG 9
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA IC3GM
UT WOS:000470847600009
PM 31096219
OA Bronze
DA 2025-06-11
ER

PT J
AU Vogel-Claussen, J
   Skrok, J
   Dombroski, D
   Shea, SM
   Shapiro, EP
   Bohlman, M
   Lorenz, CH
   Lima, JAC
   Bluemke, DA
AF Vogel-Claussen, Jens
   Skrok, Jan
   Dombroski, David
   Shea, Steven M.
   Shapiro, Edward P.
   Bohlman, Mark
   Lorenz, Christine H.
   Lima, Joao A. C.
   Bluemke, David A.
TI Comprehensive Adenosine Stress Perfusion MRI Defines the Etiology of
   Chest Pain in the Emergency Room: Comparison With Nuclear Stress Test
SO JOURNAL OF MAGNETIC RESONANCE IMAGING
LA English
DT Article
DE adenosine stress perfusion cardiac MRI; emergency room; chest pain;
   microvascular disease
ID CORONARY-ARTERY-DISEASE; CARDIAC MAGNETIC-RESONANCE;
   EMISSION-COMPUTED-TOMOGRAPHY; CONTRAST-ENHANCED MRI; SMALL VESSEL
   DISEASE; MYOCARDIAL-PERFUSION; PROGNOSTIC VALUE; MICROVASCULAR
   DYSFUNCTION; SYNDROME-X; ANGIOGRAPHY
AB Purpose: To compare standard of care nuclear SPECT imaging with cardiac magnetic resonance imaging (MRI) for emergency room (ER) patients with chest pain and intermediate probability for coronary artery disease.
   Materials and Methods: Thirty-one patients with chest pain, negative electrocardiogram (ECG), and negative cardiac enzymes who underwent cardiac single photon emission tomography (SPECT) within 24 h of ER admission were enrolled. Patients underwent a comprehensive cardiac MRI exam including gated cine imaging, adenosine stress and rest perfusion imaging and delayed enhancement imaging. Patients were followed for 14 +/- 4.7 months.
   Results: Of 27 patients, 8 (30%) showed subendocardial hypoperfusion on MRI that was not detected on SPECT. These patients had a higher rate of diabetes (P = 0.01) and hypertension (P = 0.01) and a lower global myocardial perfusion reserve (P = 0.01) compared with patients with a normal cardiac MRI (n = 10). Patients with subendocardial hypoperfusion had more risk factors for cardiovascular disease (mean 4.4) compared with patients with a normal MRI (mean 2.5; P = 0.005). During the follow-up period. patients with subendocardial hypoperfusion on stress MRI were more likely to return to the ER with chest pain compared with patients who had a normal cardiac MRI (P = 0.02). Four patients did not finish the MR exam due to claustrophobia.
   Conclusion: In patients with chest pain, diabetes and hypertension, cardiac stress perfusion MRI identified diffuse subendocardial hypoperfusion defects in the ER setting not seen on cardiac SPECT, which is suspected to reflect microvascular disease.
C1 [Vogel-Claussen, Jens; Skrok, Jan; Dombroski, David; Bohlman, Mark; Lima, Joao A. C.; Bluemke, David A.] Johns Hopkins Univ, Russell H Morgan Dept Radiol & Radiol Sci, Sch Med, Baltimore, MD 21287 USA.
   [Shapiro, Edward P.; Lima, Joao A. C.] Johns Hopkins Univ, Dept Cardiol, Sch Med, Baltimore, MD 21287 USA.
   [Shea, Steven M.; Lorenz, Christine H.] Siemens Corp Res Inc, Imaging & Visualizat, Princeton, NJ USA.
   [Bluemke, David A.] NIH, Dept Radiol & Imaging Sci, Bethesda, MD 20892 USA.
C3 Johns Hopkins University; Johns Hopkins University; Siemens AG; Siemens
   USA; National Institutes of Health (NIH) - USA
RP Vogel-Claussen, J (corresponding author), Johns Hopkins Univ, Dept Radiol, Nelson Basement MRI 143,600 N Wolfe St, Baltimore, MD 21287 USA.
EM jclauss1@jhmi.edu
RI Vogel-Claussen, Jens/Q-3374-2019; Shapiro, Edward/AAG-1611-2020;
   Bluemke, David/GYU-8169-2022
OI Vogel-Claussen, Jens/0000-0001-5595-6948; Shea,
   Steven/0000-0002-0360-4884; Bluemke, David/0000-0002-8323-8086
FU Siemens Medical Solutions. Inc. [JHU-2006-MR-27-01]
FX Contract grant sponsor: Siemens Medical Solutions. Inc.; Contract grant
   number: numbers; Contract grant number: JHU-2006-MR-27-01.
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NR 32
TC 20
Z9 22
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1053-1807
EI 1522-2586
J9 J MAGN RESON IMAGING
JI J. Magn. Reson. Imaging
PD OCT
PY 2009
VL 30
IS 4
BP 753
EP 762
DI 10.1002/jmri.21899
PG 10
WC Radiology, Nuclear Medicine & Medical Imaging
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Radiology, Nuclear Medicine & Medical Imaging
GA 503GY
UT WOS:000270522900008
PM 19787721
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Cook, SH
   Wood, EP
   Rodrigues, M
   Caldas, JJ
   Delorme, M
AF Cook, Stephanie H.
   Wood, Erica P.
   Rodrigues, Mariana
   Caldas, Janice Jachero
   Delorme, Maxline
TI Assessment of a Daily Diary Study Including Biospecimen Collections in a
   Sample of Sexual and Gender Minority Young Adults: Feasibility and
   Acceptability Study
SO JMIR FORMATIVE RESEARCH
LA English
DT Article
DE study protocol; young sexual minority men; YSSM; cardiovascular disease
   risk; health behaviors
ID C-REACTIVE PROTEIN; CORONARY-HEART-DISEASE; CARDIOVASCULAR-DISEASE;
   SUBSTANCE USE; ALCOHOL; WOMEN; RISK; DISCRIMINATION; HEALTH; MEN
AB Background: Young sexual minority men (YSMM) engage in cardiometabolic risk behaviors (eg, substance use) at high errates than their heterosexual counterparts. Theory and previous research suggest that these risk behaviors may stem, in part, from exposure to minority stress (ie, discrimination based on sexual identity and other identities such as race).Objective: This pilot study examined the feasibility and acceptability of a virtual 2-day daily diary study that examined daily experiences with discrimination, cardiometabolic risk behaviors (ie, sleep, physical activity, and substance use behaviors), and patterns of physiological stress and inflammation among YSMM aged 18 to 35 years. Methods: Participants (n=20) were recruited from the greater New York metropolitan area and engaged in a 2-day daily diary protocol wherein they provided web-based consent, took a web-based baseline survey, and then, starting the next day, provided3 saliva samples a day for 2 consecutive days to measure salivary cortisol, engaged in 3 daily diaries per day, and provided 1blood spot sample via the finger prick method to measure high-sensitivity C-reactive protein. At follow-up, participants were interviewed via videoconferencing to ascertain their experiences and feelings related to the study protocol. Qualitative analyses explored the feasibility and acceptability of the study protocol, and exploratory quantitative analyses explored the descriptive statistics and Pearson correlations among the main study variables of interest. Results: The retention rate was high (19/20, 95%) in our study sample. Qualitative analyses demonstrated that participants were willing to engage in similar, longer-term studies (eg, studies that include both week and weekend days) in the future and suggested the feasibility and acceptability of our study protocol among YSMM. However, participants noted several areas for improvement(eg, redundancy of survey items and difficulty pricking one's finger) that should be considered in future research. Preliminary quantitative analyses revealed a moderate negative correlation between everyday discrimination and mean cortisol levels (r=-0.51;P=.03). Furthermore, descriptive analyses suggest that that daily cortisol curves differ across races or ethnicities among YSMM. White and other-identified YSMM experienced the highest cortisol awakening response (mean 0.39, SD 0.21 mu g/dL for White participants; mean 0.34, SD 0.34 mu g/dL for others) with the steepest decline around bedtime (mean 0.05, SD 0.04 mu g/dL for White participants; mean 0.09, SD 0.13 mu g/dL for others) followed by a lower cortisol awakening response (mean 0.31, SD 0.11 mu g/dLfor Hispanic participants; mean 0.23, SD 0.15 mu g/dL for Black participants) and a slower decline around bedtime (mean 0.10,SD 0.09 mu g/dL for Hispanic participants; mean 0.03, SD 0.02 mu g/dL for Black participants) among Hispanic and Black YSMM. Conclusions: Overall, the results suggest that similar study protocols are feasible and acceptable among YSMM. Future research should highlight the pathways through which cardiovascular disease risk may arise among YSMM using longer-term study designs and more diverse study samples.
C1 [Cook, Stephanie H.; Wood, Erica P.; Rodrigues, Mariana; Caldas, Janice Jachero; Delorme, Maxline] NYU, Sch Global Publ Hlth, Dept Social & Behav Sci, 708 Broadway Room 757, New York, NY 10003 USA.
   [Cook, Stephanie H.] NYU, Sch Global Publ Hlth, Dept Biostat, New York, NY USA.
C3 New York University; New York University
RP Cook, SH (corresponding author), NYU, Sch Global Publ Hlth, Dept Social & Behav Sci, 708 Broadway Room 757, New York, NY 10003 USA.
EM sc5810@nyu.edu
RI Cook, Stephanie/AGF-6997-2022; Rodrigues, Mariana/KHY-5896-2024
OI Jachero Caldas, Janice/0009-0000-2102-4245; Rodrigues,
   Mariana/0000-0001-9428-4005; Wood, Erica/0000-0002-0795-6158; Cook,
   Stephanie/0000-0003-4505-0813
FU National Heart, Lung, and Blood Institute [5R25HL105446-11]
FX Acknowledgments This work was supported by the National Heart, Lung, and
   Blood Institute (5R25HL105446-11; principal investigator, Mohamed
   Boutjdir) .
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NR 53
TC 1
Z9 1
U1 1
U2 6
PU JMIR PUBLICATIONS, INC
PI TORONTO
PA 130 QUEENS QUAY East, Unit 1100, TORONTO, ON M5A 0P6, CANADA
EI 2561-326X
J9 JMIR FORM RES
JI JMIR Form. Res.
PY 2024
VL 8
AR e52195
DI 10.2196/52195
PG 17
WC Health Care Sciences & Services; Medical Informatics
WE Emerging Sources Citation Index (ESCI)
SC Health Care Sciences & Services; Medical Informatics
GA LB8C5
UT WOS:001184400000002
PM 38373036
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Kerns, SL
   Fung, C
   Monahan, PO
   Ardeshir-Rouhani-Fard, S
   Abu Zaid, MI
   Williams, AM
   Stump, TE
   Sesso, HD
   Feldman, DR
   Hamilton, RJ
   Vaughn, DJ
   Beard, C
   Huddart, RA
   Kim, J
   Kollmannsberger, C
   Sahasrabudhe, DM
   Cook, R
   Fossa, SD
   Einhorn, LH
   Travis, LB
AF Kerns, Sarah L.
   Fung, Chunkit
   Monahan, Patrick O.
   Ardeshir-Rouhani-Fard, Shirin
   Abu Zaid, Mohammad I.
   Williams, AnnaLynn M.
   Stump, Timothy E.
   Sesso, Howard D.
   Feldman, Darren R.
   Hamilton, Robert J.
   Vaughn, David J.
   Beard, Clair
   Huddart, Robert A.
   Kim, Jeri
   Kollmannsberger, Christian
   Sahasrabudhe, Deepak M.
   Cook, Ryan
   Fossa, Sophie D.
   Einhorn, Lawrence H.
   Travis, Lois B.
CA Platinum Study Grp
TI Cumulative Burden of Morbidity Among Testicular Cancer Survivors After
   Standard Cisplatin-Based Chemotherapy: A Multi-Institutional Study
SO JOURNAL OF CLINICAL ONCOLOGY
LA English
DT Article
ID LONG-TERM SURVIVORS; INDUCED PERIPHERAL NEUROPATHY; ADVERSE HEALTH
   OUTCOMES; GERM-CELL TUMORS; QUALITY-OF-LIFE; ERECTILE DYSFUNCTION;
   METABOLIC SYNDROME; CARDIOVASCULAR-DISEASE; THYROID-DISORDERS; SYMPTOM
   CLUSTERS
AB PurposeIn this multicenter study, we evaluated the cumulative burden of morbidity (CBM) among > 1,200 testicular cancer survivors and applied factor analysis to determine the co-occurrence of adverse health outcomes (AHOs).Patients and MethodsParticipants were 55 years of age at diagnosis, finished first-line chemotherapy 1 year previously, completed a comprehensive questionnaire, and underwent physical examination. Treatment data were abstracted from medical records. A CBM score encompassed the number and severity of AHOs, with ordinal logistic regression used to assess associations with exposures. Nonlinear factor analysis and the nonparametric dimensionality evaluation to enumerate contributing traits procedure determined which AHOs co-occurred.ResultsAmong 1,214 participants, approximately 20% had a high (15%) or very high/severe (4.1%) CBM score, whereas approximately 80% scored medium (30%) or low/very low (47%). Increased risks of higher scores were associated with four cycles of either ifosfamide, etoposide, and cisplatin (odds ratio [OR], 1.96; 95% CI, 1.04 to 3.71) or bleomycin, etoposide, and cisplatin (OR, 1.44; 95% CI, 1.04 to 1.98), older attained age (OR, 1.18; 95% CI, 1.10 to 1.26), current disability leave (OR, 3.53; 95% CI, 1.57 to 7.95), less than a college education (OR, 1.44; 95% CI, 1.11 to 1.87), and current or former smoking (OR, 1.28; 95% CI, 1.02 to 1.63). CBM score did not differ after either chemotherapy regimen (P = .36). Asian race (OR, 0.41; 95% CI, 0.23 to 0.72) and vigorous exercise (OR, 0.68; 95% CI, 0.52 to 0.89) were protective. Variable clustering analyses identified six significant AHO clusters (P-2 < .001): hearing loss/damage, tinnitus (OR, 16.3); hyperlipidemia, hypertension, diabetes (OR, 9.8); neuropathy, pain, Raynaud phenomenon (OR, 5.5); cardiovascular and related conditions (OR, 5.0); thyroid disease, erectile dysfunction (OR, 4.2); and depression/anxiety, hypogonadism (OR, 2.8).ConclusionFactors associated with higher CBM may identify testicular cancer survivors in need of closer monitoring. If confirmed, identified AHO clusters could guide the development of survivorship care strategies.
C1 [Kerns, Sarah L.; Fung, Chunkit; Williams, AnnaLynn M.; Sahasrabudhe, Deepak M.] Univ Rochester, Med Ctr, Rochester, NY 14642 USA.
   [Feldman, Darren R.] Mem Sloan Kettering Canc Ctr, 1275 York Ave, New York, NY 10021 USA.
   [Monahan, Patrick O.; Ardeshir-Rouhani-Fard, Shirin; Abu Zaid, Mohammad I.; Stump, Timothy E.; Cook, Ryan; Einhorn, Lawrence H.; Travis, Lois B.] Indiana Univ, Indianapolis, IN 46204 USA.
   [Sesso, Howard D.] Brigham & Womens Hosp, Boston, MA 02115 USA.
   [Beard, Clair] Dana Farber Canc Inst, Boston, MA 02115 USA.
   [Hamilton, Robert J.] Princess Margaret Canc Ctr, Toronto, ON, Canada.
   [Kollmannsberger, Christian] Univ British Columbia, Vancouver, BC V5Z 1M9, Canada.
   [Vaughn, David J.] Univ Penn, Philadelphia, PA 19104 USA.
   [Huddart, Robert A.] Royal Marsden Hosp, London, England.
   [Kim, Jeri] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA.
   [Fossa, Sophie D.] Oslo Univ Hosp, Oslo, Norway.
C3 University of Rochester; Memorial Sloan Kettering Cancer Center; Indiana
   University System; Indiana University Indianapolis; Harvard University;
   Harvard University Medical Affiliates; Brigham & Women's Hospital;
   Harvard University; Harvard University Medical Affiliates; Dana-Farber
   Cancer Institute; University of Toronto; University Health Network
   Toronto; Princess Margaret Cancer Centre; University of British
   Columbia; University of Pennsylvania; Royal Marsden NHS Foundation
   Trust; University of Texas System; UTMD Anderson Cancer Center;
   University of Oslo
RP Einhorn, LH (corresponding author), Indiana Univ, Melvin & Bren Simon Canc Ctr, Dept Med Oncol, 535 Barnhill Dr,RT432, Indianapolis, IN 46202 USA.
EM leinhorn@iupui.edu
RI Abu Zaid, Mohammad/AFO-3625-2022
OI huddart, robert/0000-0003-3604-1990; Feldman,
   Darren/0000-0003-2424-4635; Williams, AnnaLynn/0000-0002-7042-5851;
   Silber, Deborah/0000-0002-0610-8712
FU National Cancer Institute [1R01 CA157823, K07 CA187546]
FX Supported by the National Cancer Institute (1R01 CA157823 to L.B.T. and
   K07 CA187546 to S.L.K.).
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NR 72
TC 88
Z9 91
U1 1
U2 6
PU AMER SOC CLINICAL ONCOLOGY
PI ALEXANDRIA
PA 2318 MILL ROAD, STE 800, ALEXANDRIA, VA 22314 USA
SN 0732-183X
EI 1527-7755
J9 J CLIN ONCOL
JI J. Clin. Oncol.
PD MAY 20
PY 2018
VL 36
IS 15
BP 1505
EP +
DI 10.1200/JCO.2017.77.0735
PG 17
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Oncology
GA GH7NI
UT WOS:000433635100008
PM 29617189
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Uwah, EA
   Cicalese, O
   Davis, B
   Neelapu, M
   Steinberg, G
   Handa, A
   Johnson, TJ
   Mindell, JA
   Njoroge, WFM
   Stefanovski, D
   Tapia, IE
   Waller, R
   Williamson, AA
AF Uwah, Eberechukwu A.
   Cicalese, Olivia
   Davis, Brizhay
   Neelapu, Megha
   Steinberg, Gabriel
   Handa, Arun
   Johnson, Tiffani J.
   Mindell, Jodi A.
   Njoroge, Wanjiku F. M.
   Stefanovski, Darko
   Tapia, Ignacio E.
   Waller, Rebecca
   Williamson, Ariel A.
TI Socioecological factors linked to co-occurring early childhood sleep
   health disparities and developmental outcomes: protocol for the sleep in
   preschoolers cross-sectional study
SO BMJ OPEN
LA English
DT Article
DE SLEEP MEDICINE; PAEDIATRICS; Behavior; Cross-Sectional Studies
ID EXECUTIVE FUNCTION; MENTAL-HEALTH; RISK-FACTORS; ENVIRONMENTAL
   EXPOSURES; CARDIOMETABOLIC RISK; SOCIOECONOMIC-STATUS; AGED CHILDREN;
   IMPLICIT BIAS; INFANT SLEEP; RACIAL BIAS
AB Introduction Sleep deficiencies, such as sleep disordered breathing (SDB) and insufficient sleep, are linked to adverse health outcomes. These sleep deficiencies are more common in racial and ethnic minoritised children and have significant negative impacts on neurobehavioural and social-emotional development. Non-Latine Black/African American children are 4-6 times more likely than non-Latine White children to experience both SDB and short sleep duration. Although SDB and insufficient sleep often co-occur in young children, there is a paucity of research considering the potential unique and additive impacts of SDB and insufficient sleep on child outcomes, as well as racial disparities in these outcomes, thus hindering comprehensive interventions. Our study objectives are to (1) examine racial disparities in the neurobehavioural and social-emotional impacts of early childhood SDB and/or insufficient sleep and (2) identify proximal and distal socioecological factors linked to these sleep disparities and outcomes.Methods and analysis A cross-sectional observational study comparing neurobehavioural (executive functioning, attention, vigilance) and social-emotional functioning (social skills, emotion regulation) in 400 dyads consisting of caregivers and their otherwise healthy Black and White 3-5 year-old children and divided into four groups: (A) preschoolers with SDB; (B) preschoolers with insufficient sleep; (C) preschoolers with both SDB and insufficient sleep and (D) matched controls. Child SDB, insufficient sleep, neurobehavioural skills and social-emotional functioning are measured using validated objective and subjective assessment tools, with a subset of caregivers completing qualitative interviews. Primary outcomes include individual differences in neurobehavioural and social-emotional functioning in these groups of Black and White preschoolers, and multilevel socioecological factors associated with variation in outcomes. Quantitative data will be analysed using descriptive analyses, linear regression and comparison of model coefficients. Qualitative data will be coded using thematic analysis and a joint display to stratify qualitative themes by child race and sleep deficiencies.Ethics and dissemination The study protocol has been approved by the institutional review board of the Children's Hospital of Philadelphia and the University of Oregon. Results will be disseminated through peer-reviewed publications and conferences.
C1 [Uwah, Eberechukwu A.; Cicalese, Olivia; Davis, Brizhay; Neelapu, Megha; Handa, Arun; Mindell, Jodi A.; Tapia, Ignacio E.; Williamson, Ariel A.] Childrens Hosp Philadelphia, Philadelphia, PA 19104 USA.
   [Davis, Brizhay; Williamson, Ariel A.] Univ Oregon, Ballmer Inst Childrens Behav Hlth, Portland, OR 97209 USA.
   [Steinberg, Gabriel] Univ Penn, Dept Biol, Philadelphia, PA USA.
   [Handa, Arun; Njoroge, Wanjiku F. M.] Univ Penn, Perelman Sch Med, Philadelphia, PA USA.
   [Johnson, Tiffani J.] Univ Calif Davis, Sch Med, Dept Emergency Med, Sacramento, CA USA.
   [Johnson, Tiffani J.] Univ Calif Davis, Dept Pediat, Sch Med, Sacramento, CA USA.
   [Mindell, Jodi A.] St Josephs Univ, Dept Psychol, Philadelphia, PA USA.
   [Njoroge, Wanjiku F. M.] Childrens Hosp Philadelphia, Dept Child & Adolescent Psychiat & Behav Sci, Philadelphia, PA USA.
   [Stefanovski, Darko] Univ Penn, Sch Vet Med, Philadelphia, PA USA.
   [Tapia, Ignacio E.] Univ Miami, Miller Sch Med, Miami, FL USA.
   [Waller, Rebecca] Univ Penn, Dept Psychol, Philadelphia, PA USA.
C3 University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of
   Philadelphia; University of Oregon; University of Pennsylvania;
   University of Pennsylvania; University of California System; University
   of California Davis; University of California System; University of
   California Davis; Saint Joseph's University; University of Pennsylvania;
   Pennsylvania Medicine; Childrens Hospital of Philadelphia; University of
   Pennsylvania; University of Miami; University of Pennsylvania
RP Williamson, AA (corresponding author), Childrens Hosp Philadelphia, Philadelphia, PA 19104 USA.; Williamson, AA (corresponding author), Univ Oregon, Ballmer Inst Childrens Behav Hlth, Portland, OR 97209 USA.
EM uwahe@chop.edu; CICALESEO@chop.edu; davisb12@chop.edu;
   mneelapu@sas.upenn.edu; gabriel4@upenn.edu; HANDAA@chop.edu;
   tjo@ucdavis.edu; jmindell@sju.edu; NJOROGEW@chop.edu;
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   arielaw@uoregon.edu
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FX We thank the Research Family Partners Program and the network of primary
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   this project and clinical research facilities through the Pediatric
   Research Consortium at the Children's Hospital of Philadelphia.
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NR 152
TC 0
Z9 0
U1 1
U2 1
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2044-6055
J9 BMJ OPEN
JI BMJ Open
PD MAR 19
PY 2025
VL 15
IS 3
AR e100956
DI 10.1136/bmjopen-2025-100956
PG 18
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 0NZ8L
UT WOS:001451914800001
PM 40118487
OA gold
DA 2025-06-11
ER

PT J
AU Anthony, DC
   Probert, F
   Gorlova, A
   Hebert, J
   Radford-Smith, D
   Nefedova, Z
   Umriukhin, A
   Nedorubov, A
   Cespuglio, R
   Shulgin, B
   Lyundup, A
   Lesch, KP
   Strekalova, T
AF Anthony, Daniel C.
   Probert, Fay
   Gorlova, Anna
   Hebert, Jenna
   Radford-Smith, Daniel
   Nefedova, Zlata
   Umriukhin, Aleksei
   Nedorubov, Andrey
   Cespuglio, Raymond
   Shulgin, Boris
   Lyundup, Aleksey
   Lesch, Klaus Peter
   Strekalova, Tatyana
TI Impact of Serotonin Transporter Absence on Brain Insulin Receptor
   Expression, Plasma Metabolome Changes, and ADHD-like Behavior in Mice
   fed a Western Diet
SO BIOMOLECULES
LA English
DT Article
DE serotonin transporter; Sert-deficient mice; western diet; metabolomics;
   glucose tolerance; insulin receptors; ADHD; aging
ID TLR4 UP-REGULATION; DEPRESSION; OBESITY; GENE; KNOCKOUT; RISK;
   HIPPOCAMPUS; SENSITIVITY; GENDER; MODEL
AB The impaired function of the serotonin transporter (SERT) in humans has been linked to a higher risk of obesity and type 2 diabetes, especially as people age. Consuming a "Western diet" (WD), which is high in saturated fats, cholesterol, and sugars, can induce metabolic syndrome. Previous research indicated that mice carrying a targeted inactivation of the Sert gene (knockout, KO) and fed a WD display significant metabolic disturbances and behaviors reminiscent of ADHD. These abnormalities might be mediated via a dysfunction in insulin receptor (IR) signaling, which is also associated with adult ADHD. However, the impact of Sert deficiency on IR signaling and systemic metabolic changes has not been thoroughly explored. In this study, we conducted a detailed analysis of locomotor behavior in wild-type (WT) and KO mice fed a WD or control diet. We investigated changes in the blood metabolome and examined, via PCR, the expression of insulin receptor A and B isoforms and key regulators of their function in the brain. Twelve-month-old KO mice and their WT littermates were fed a WD for three weeks. Nuclear magnetic resonance spectroscopy analysis of plasma samples showed that KO mice on a WD had higher levels of lipids and lipoproteins and lower levels of glucose, lactate, alanine, valine, and isoleucine compared to other groups. SERT-KO mice on the control diet exhibited increased brain levels of both IR A and B isoforms, accompanied by a modest increase in the negative regulator ENPP. The KO mice also displayed anxiety-like behavior and reduced exploratory activity in an open field test. However, when the KO animals were fed a WD, the aberrant expression levels of IR isoforms in the KO mice and locomotor behavior were ameliorated indicating a complex interaction between genetic and dietary factors that might contribute to ADHD-like symptoms. Overall, our findings suggest that the lack of Sert leads to a unique metabolic phenotype in aged mice, characterized by dysregulated IR-related pathways. These changes are exacerbated by WD in the blood metabolome and are associated with behavioral abnormalities.
C1 [Anthony, Daniel C.; Probert, Fay; Hebert, Jenna; Radford-Smith, Daniel; Strekalova, Tatyana] Univ Oxford, Dept Pharmacol, Oxford OX1 3QT, England.
   [Probert, Fay] Univ Oxford, Dept Chem, Oxford OX1 2JD, England.
   [Gorlova, Anna; Cespuglio, Raymond; Lyundup, Aleksey] Peoples Friendship Univ Russia, RUDN Univ, Res & Educ Resource Ctr, Moscow 117198, Russia.
   [Nefedova, Zlata; Umriukhin, Aleksei; Nedorubov, Andrey] Sechenov First Moscow State Med Univ, Dept Normal Physiol, Moscow 119991, Russia.
   [Shulgin, Boris] Korkyt Ata Kyzylorda Univ, Lab Engn Profile Phys & Chem Methods Anal, Kyzylorda 120014, Kazakhstan.
   [Lyundup, Aleksey] Endocrinol Res Ctr, Dmitry Ulyanov Str 19, Moscow 117036, Russia.
   [Lesch, Klaus Peter] Univ Hosp Wurzburg, Ctr Mental Hlth, Div Mol Psychiat, D-97080 Wurzburg, Germany.
   [Lesch, Klaus Peter] Univ Hosp Wurzburg, Dept Child & Adolescent Psychiat Psychosomat & Psy, Ctr Mental Hlth, D-97080 Wurzburg, Germany.
C3 University of Oxford; University of Oxford; Peoples Friendship
   University of Russia; Sechenov First Moscow State Medical University;
   Russian Academy of Medical Sciences; Endocrinology Research Centre;
   University of Wurzburg; University of Wurzburg
RP Strekalova, T (corresponding author), Univ Oxford, Dept Pharmacol, Oxford OX1 3QT, England.
EM daniel.anthony@pharm.ox.ac.uk; fay.probert@chem.ox.ac.uk;
   anna.gorlova204@gmail.com; hebertjcr@gmail.com;
   daniel.radford-smith@some.ox.ac.uk; zlanefedova@gmail.com;
   alum1@yandex.ru; nedorubov.ras@gmail.com; raymond.cespuglio@sfr.fr;
   bshulgin83@gmail.com; lyundup2020@gmail.com;
   kplesch@mail.uni-wuerzburg.de; tatyana.strekalova@pharm.ox.ac.uk
RI Lesch, Klaus-Peter/J-4906-2013; Недорубов, Андрей
   Анатольевич/AIF-4441-2022; Radford-Smith, Daniel/IUQ-7645-2023; Anthony,
   Daniel/ITT-4206-2023
OI Anthony, Daniel/0000-0003-1380-6655; Nedorubov, Andrei
   Anatol'evic/0000-0002-5915-7999
FU European Union's HORIZON-MSCA-SE-2021 research and innovation program
   under the Marie Sklstrok;odowvska-Curie [2021-2025]; Aqua-Synapse EU
   [101007642]; European Union [RF 075-15-2022-310, UKRI EP/Y000420/1];
   Ministry of Research and Higher Education
FX This study was supported by Aqua-Synapse EU framework (to DA and TS) and
   PhytoAPP EU framework (2021-2025, to TS, and DA). The AquaSynapse
   project has received funding from the European Union's
   HORIZON-MSCA-SE-2021 research and innovation program under the Marie Sk
   & lstrok;odowvska-Curie grant agreement 101086453. The PhytoAPP project
   has received funding from the European Union's HORIZON 2020 research and
   innovation program under the Marie Sk & lstrok;odowvska-Curie grant
   agreement 101007642. This study was also supported by the Ministry of
   Research and Higher Education RF 075-15-2022-310 and UKRI EP/Y000420/1.
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NR 89
TC 2
Z9 2
U1 2
U2 4
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2218-273X
J9 BIOMOLECULES
JI Biomolecules
PD AUG
PY 2024
VL 14
IS 8
AR 884
DI 10.3390/biom14080884
PG 20
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA F0M4V
UT WOS:001306847600001
PM 39199273
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Liu, XE
   Tian, X
   Wang, LA
   Zhang, XY
AF Liu, Xiaoen
   Tian, Xue
   Wang, Lina
   Zhang, Xiangyang
TI Prevalence and associated factors of obesity in patients with major
   depressive disorder at different ages of onset
SO EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
LA English
DT Article; Early Access
DE Major depressive disorder; Different ages of onset; Obesity; Overweight
ID METABOLIC SYNDROME; POOLED ANALYSIS; WOMEN; ANTIDEPRESSANTS;
   COMORBIDITY; WEIGHT
AB Major depressive disorder (MDD) and obesity are two serious public health problems. Although there have been some research on both, there have few studies on differences in obesity among MDD patients at different ages of onset. The study aims to evaluate the prevalence and factors associated with obesity in MDD patients at different ages of onset. This study totally recruited 1718 first-episode drug-naive MDD patients aged from 18 to 60 years. All subjects were divided into two subgroups: early adulthood onset (EAO, 18-45 years) and mid-adulthood onset (MAO, 45-60 years). Clinical symptoms of patients were evaluated using the 17-item Hamilton Depression Rating Scale (HAMD-17), Hamilton Anxiety Scale (HAMA), and Positive and Negative Syndrome Scale (PANSS) positive subscale. Baseline parameters including body mass index (BMI), blood pressure, and hematological biochemical parameters were assessed to investigate the association between these parameters and weight gain risk. The percentages of overweight and obesity patients with MDD in EAO group were 54.4% and 4.1%, respectively, and the percentages of overweight and obesity patients with MDD in MAO group were 60.4% and 2.8%, respectively. MDD patients in the MAO group had a longer duration of illness and higher scores in HAMD, HAMA, and PANSS positive subscale. They also had higher levels of thyroid stimulating hormone (TSH), anti-thyroglobulin (TgAb), fasting blood glucose (FBG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), systolic and diastolic blood pressures (SBP and DBP) levels. BMI did not differ significantly between the two groups. In the EAO group, statistically significant differences were found among normal weight, overweight and obese group in duration of illness, age of onset, TSH, TgAb, thyroid peroxidase antibody (TPOAb), free thyroxine (FT4), TC, triglycerides (TG), SBP and DBP. The TSH, TgTb and SBP were identified as risk factors for weight gain. In the MAO group, statistically significant differences were found among normal weight, overweight and obese group in TSH and FBG. The two indicators were identified as risk factors for weight gain. There were no significant differences in the weight of MDD patients at different ages of onset, while the factors that could potentially lead to obesity did show some differences.
C1 [Liu, Xiaoen; Tian, Xue; Wang, Lina] Tianjin Anding Hosp, Inst Mental Hlth, Tianjin, Peoples R China.
   [Zhang, Xiangyang] Chinese Acad Sci, Univ Chinese Acad Sci, Inst Psychol, Dept Psychol, Beijing, Peoples R China.
C3 Chinese Academy of Sciences; University of Chinese Academy of Sciences,
   CAS
RP Zhang, XY (corresponding author), Chinese Acad Sci, Univ Chinese Acad Sci, Inst Psychol, Dept Psychol, Beijing, Peoples R China.
EM zhangxy@psych.ac.cn
RI Zhang, Xiangyang/ABC-7380-2022
OI Zhang, Xiangyang/0000-0003-3326-382X; Xue, Tian/0000-0003-0671-0356
FU Tianjin Key Medical Discipline (Specialty) Construction Project
FX We are grateful to all the clinical physicians and nurses that
   participated in our current study and also to those research staff that
   contributed to the clinical assessments.
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NR 77
TC 0
Z9 0
U1 2
U2 3
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0940-1334
EI 1433-8491
J9 EUR ARCH PSY CLIN N
JI Eur. Arch. Psych. Clin. Neurosci.
PD 2024 MAR 15
PY 2024
DI 10.1007/s00406-024-01766-3
EA MAR 2024
PG 10
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Psychiatry
GA KX5Q5
UT WOS:001183282300001
PM 38485814
DA 2025-06-11
ER

PT J
AU Burkard, T
   Vallejo-Yagüe, E
   Hügle, T
   Finckh, A
   Burden, AM
AF Burkard, Theresa
   Vallejo-Yague, Enriqueta
   Huegle, Thomas
   Finckh, Axel
   Burden, Andrea Michelle
TI Interruptions of biological and targeted synthetic disease-modifying
   antirheumatic drugs in rheumatoid arthritis: a descriptive cohort study
   assessing trends in patient characteristics in Switzerland
SO BMJ OPEN
LA English
DT Article
DE rheumatology; epidemiology; public health
ID DISCONTINUATION; THERAPY; LEFLUNOMIDE; DEPRESSION; MANAGEMENT; ANXIETY;
   RATES; RISK
AB Objectives To identify differing patient characteristics at the time of stop and restart of biological or targeted synthetic disease-modifying antirheumatic drugs (b/tsDMARDs) in rheumatoid arthritis (RA), stratified by stop reason. Design Explorative descriptive cohort study. Setting Swiss Clinical Quality Management in Rheumatic Diseases (1999-2018). Participants Patients with RA who stopped their first b/tsDMARD. Outcome measures We assessed patient characteristics at b/tsDMARD stop and restart, stratified by stop reason (non-response, adverse event, remission, other). Results Among 2526 eligible patients, most patients (38%) stopped their b/tsDMARD due to non-response. At treatment stop, most characteristics did not differ by stop reason, yet some differed significantly (p<0.0001, those stopping due to remission had lowest median Health Assessment Questionnaire measurements (0.1) and were least likely to use leflunomide combination therapy (3.9%) and to have fibromyalgia (6.7%)). The majority of patients restarted b/tsDMARDs without changes in patient characteristics at restart. However, among the 48% of patients who restarted a b/tsDMARD after having previously stopped due to remission or other reasons, disease activity measurements were significantly worse compared with treatment stop date (mean disease activity score-erythrocyte sedimentation rate score of 2.0 at b/tsDMARD restart vs 3.5 at treatment stop (p<0.0001)). Furthermore, we observed non-significant trends in several patient characteristics (eg, higher proportion of women (75% at b/tsDMARD restart vs 70% at treatment stop, p=0.38), patients with seropositivity (anti-citrullinated protein antibody positive 67% vs 58%, p=0.25), with family history of rheumatic diseases (24% vs 20%, p=0.15), osteoarthritis/arthroplasty (25% vs 20%, p=0.34) and the metabolic syndrome (11% vs 6%, p=0.15). Conclusion Differences among patient characteristics across b/tsDMARD cessation strata were few. However, differences between stop and restart may have identified an RA phenotype that is challenging to treat. Further research on identifying the patient characteristics predictive of successful drug holidays and the optimal time to initiate and stop a drug holiday is warranted.
C1 [Burkard, Theresa; Vallejo-Yague, Enriqueta; Burden, Andrea Michelle] Swiss Fed Inst Technol, Dept Chem & Appl Biosci, Inst Pharmaceut Sci, Zurich, Switzerland.
   [Huegle, Thomas] Univ Lusanne, Lusanne Univ Hosp, Dept Rheumatol, Lausanne, Switzerland.
   [Finckh, Axel] HUG, Div Rheumatol, Geneva, Switzerland.
C3 Swiss Federal Institutes of Technology Domain; ETH Zurich; University of
   Geneva
RP Burden, AM (corresponding author), Swiss Fed Inst Technol, Dept Chem & Appl Biosci, Inst Pharmaceut Sci, Zurich, Switzerland.
EM andrea.burden@pharma.ethz.ch
RI Vallejo-Yagüe, Enriqueta/KCX-8887-2024; Finckh, Axel/AFN-1169-2022;
   Burden, Andrea/B-3004-2016
OI Hugle, Thomas/0000-0002-3276-9581; Vallejo-Yague,
   Enriqueta/0000-0002-5911-2037; Burden, Andrea/0000-0001-7082-8530
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NR 28
TC 1
Z9 1
U1 0
U2 2
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2044-6055
J9 BMJ OPEN
JI BMJ Open
PD MAR
PY 2022
VL 12
IS 3
AR e056352
DI 10.1136/bmjopen-2021-056352
PG 11
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA ZV1UN
UT WOS:000770320300001
PM 35292498
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Karppanen, T
   Kaartokallio, T
   Klemetti, MM
   Heinonen, S
   Kajantie, E
   Kere, J
   Kivinen, K
   Pouta, A
   Staff, AC
   Laivuori, H
AF Karppanen, Tiina
   Kaartokallio, Tea
   Klemetti, Miira M.
   Heinonen, Seppo
   Kajantie, Eero
   Kere, Juha
   Kivinen, Katja
   Pouta, Anneli
   Staff, Anne Cathrine
   Laivuori, Hannele
TI An RGS2 3′UTR polymorphism is associated with preeclampsia in
   overweight women
SO BMC GENETICS
LA English
DT Article
DE Preeclampsia; Pregnancy; Regulator of G-protein signaling 2; Candidate
   gene study
ID BLOOD-PRESSURE; CARDIOVASCULAR-DISEASE; C1114G POLYMORPHISM; METABOLIC
   SYNDROME; RISK-FACTORS; ANXIETY; OBESITY; HYPERTENSION; REGULATOR;
   PREGNANCY
AB Background: Preeclampsia is a common and heterogeneous vascular syndrome of pregnancy. Its genetic risk profile is yet unknown and may vary between individuals and populations. The rs4606 3'UTR polymorphism of the Regulator of G-protein signaling 2 gene (RGS2) in the mother has been implicated in preeclampsia as well as in the development of chronic hypertension after preeclampsia. The RGS2 protein acts as an inhibitor of physiological vasoconstrictive pathways, and a low RGS2 level is associated with hypertension and obesity, two conditions that predispose to preeclampsia. We genotyped the rs4606 polymorphism in 1339 preeclamptic patients and in 697 controls from the Finnish Genetics of Preeclampsia Consortium (FINNPEC) cohort to study the association of the variant with preeclampsia.
   Results: No association between rs4606 and preeclampsia was detected in the analysis including all women. However, the polymorphism was associated with preeclampsia in a subgroup of overweight women (body mass index >= 25 kg/m(2), and < 30 kg/m(2)) (dominant model; odds ratio, 1.64; 95 % confidence interval, 1.10-2.42).
   Conclusions: Our results suggest that RGS2 might be involved in the pathogenesis of preeclampsia particularly in overweight women and contribute to their increased risk for hypertension and other types of cardiovascular disease later in life.
C1 [Karppanen, Tiina; Kaartokallio, Tea; Klemetti, Miira M.; Kere, Juha; Laivuori, Hannele] Univ Helsinki, Med & Clin Genet, Helsinki, Finland.
   [Karppanen, Tiina; Kaartokallio, Tea; Klemetti, Miira M.; Heinonen, Seppo; Kere, Juha; Laivuori, Hannele] Helsinki Univ Hosp, Helsinki, Finland.
   [Klemetti, Miira M.; Heinonen, Seppo; Laivuori, Hannele] Univ Helsinki, Obstet & Gynecol, Helsinki, Finland.
   [Klemetti, Miira M.] South Karelia Cent Hosp, Dept Obstet & Gynecol, Lappeenranta, Finland.
   [Kajantie, Eero] Natl Inst Hlth & Welf, Chron Dis Prevent Unit, Helsinki, Finland.
   [Kajantie, Eero] Univ Helsinki, Cent Hosp, Childrens Hosp, Helsinki, Finland.
   [Kajantie, Eero] Univ Helsinki, Helsinki, Finland.
   [Kajantie, Eero; Pouta, Anneli] Oulu Univ Hosp, MRC Oulu, PEDEGO Res Unit, Oulu, Finland.
   [Kajantie, Eero; Pouta, Anneli] Univ Oulu, Oulu, Finland.
   [Kere, Juha] Karolinska Inst, Dept Biosci & Nutr, Stockholm, Sweden.
   [Kere, Juha] Karolinska Inst, Sci Life Lab, Stockholm, Sweden.
   [Kere, Juha] Folkhalsan Inst Genet, Helsinki, Finland.
   [Kivinen, Katja] Univ Cambridge, Div Cardiovasc Med, Cambridge, England.
   [Pouta, Anneli] Natl Inst Hlth & Welf, Dept Govt Serv, Helsinki, Finland.
   [Staff, Anne Cathrine] Univ Oulu, Fac Med, Oslo, Norway.
   [Staff, Anne Cathrine] Oslo Univ Hosp, Dept Obstet & Gynecol, Oslo, Norway.
   [Laivuori, Hannele] Univ Helsinki, Inst Mol Med Finland, Helsinki, Finland.
C3 University of Helsinki; University of Helsinki; Helsinki University
   Central Hospital; University of Helsinki; Finland National Institute for
   Health & Welfare; University of Helsinki; Helsinki University Central
   Hospital; University of Helsinki; University of Oulu; University of
   Oulu; Karolinska Institutet; Karolinska Institutet; University of
   Cambridge; Finland National Institute for Health & Welfare; University
   of Oslo; University of Helsinki
RP Karppanen, T (corresponding author), Univ Helsinki, Med & Clin Genet, Helsinki, Finland.; Karppanen, T (corresponding author), Helsinki Univ Hosp, Helsinki, Finland.
EM tiina.karppanen@helsinki.fi
RI Hanhineva, Kati/AAH-1699-2019; Klemetti, Miira/NIV-0774-2025; Kere,
   Juha/A-9179-2008; Laivuori, Hannele/F-2953-2011
OI Kere, Juha/0000-0003-1974-0271; Kivinen, Katja/0000-0002-1135-7625;
   Laivuori, Hannele/0000-0003-3212-7826; Klemetti,
   Miira/0000-0001-9038-130X
FU Jane and Aatos Erkko Foundation; Paivikki and Sakari Sohlberg
   Foundation; Academy of Finland; University of Helsinki; Government
   special state subsidy for health sciences (Erityisvaltionosuus funding)
   at the Hospital District of Helsinki and Uusimaa; Novo Nordisk
   Foundation; Finnish Foundation for Pediatric Research; Emil Aaltonen
   Foundation; Sigrid Juselius Foundation; Doctoral Programme in
   Biomedicine; Clinical Graduate Program; Research Foundation of the
   University of Helsinki; Biomedicum Helsinki Foundation; National
   Graduate School of Clinical Investigation; Paulo Foundation
FX The Finnish Genetics of Pre-eclampsia Consortium (FINNPEC) study was
   supported by Jane and Aatos Erkko Foundation, Paivikki and Sakari
   Sohlberg Foundation, Academy of Finland, Research Funds of the
   University of Helsinki, Government special state subsidy for health
   sciences (Erityisvaltionosuus funding) at the Hospital District of
   Helsinki and Uusimaa, Novo Nordisk Foundation, Finnish Foundation for
   Pediatric Research, Emil Aaltonen Foundation, and Sigrid Juselius
   Foundation. T. Kaartokallio was supported by Doctoral Programme in
   Biomedicine, Clinical Graduate Program, Research Foundation of the
   University of Helsinki and Biomedicum Helsinki Foundation. M.M. Klemetti
   was supported by the Research Foundation of the University of Helsinki,
   Paulo Foundation, and the National Graduate School of Clinical
   Investigation.
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NR 48
TC 15
Z9 21
U1 0
U2 5
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1471-2156
J9 BMC GENET
JI BMC Genet.
PD AUG 24
PY 2016
VL 17
AR 121
DI 10.1186/s12863-016-0428-8
PG 7
WC Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Genetics & Heredity
GA DU4VN
UT WOS:000382210900001
PM 27558088
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Lee, JW
   Park, KD
   Im, JA
   Kim, MY
   Lee, DC
AF Lee, Ji-Won
   Park, Ki Deok
   Im, Jee-Aee
   Kim, Moo Young
   Lee, Duk-Chul
TI Mitochondrial DNA copy number in peripheral blood is associated with
   cognitive function in apparently healthy elderly women
SO CLINICA CHIMICA ACTA
LA English
DT Article
DE Mitochondrial function; Cognition; Elderly
ID ALZHEIMERS-DISEASE; OXIDATIVE STRESS; NEURODEGENERATIVE DISORDERS;
   INSULIN-RESISTANCE; QUANTITATIVE PCR; SKELETAL-MUSCLE; GAIT SPEED;
   DYSFUNCTION; AGE; ABNORMALITIES
AB Background: The identification of early markers of dementia is of increasing clinical importance. Recently, impaired mitochondrial function has emerged as a potential marker for age-related diseases and the maintenance of mtDNA copy number is essential for the preservation of mitochondrial function. We investigated the association between mtDNA copy number and cognitive function in elderly women.
   Methods: A total of 107 apparently healthy elderly women were included. Cognitive abilities were assessed using the Mini-Mental State Examination (MMSE). We measured mtDNA copy number in peripheral leukocytes using real-time polymerase chain reaction (PCR) methods. Additionally, cardiometabolic risk factors and physical function were measured.
   Results: MMSE scores were negatively correlated with the homeostasis model of insulin resistance (HOMA-IR) scores and positively correlated with gait speed as well as mtDNA copy number. After adjusting for age and level of education, the mean values of MMSE scores gradually increased with mtDNA copy number when divided into quartiles. Using step-wise multiple regression analysis, gait speed, mtDNA copy number, and age were determined to be the strongest predictors of MMSE score.
   Conclusions: These data suggest that reduced mtDNA content may be a possible early marker of dementia, and this finding warrants further study in large, prospective investigations. (C) 2010 Published by Elsevier B.V.
C1 [Lee, Ji-Won; Kim, Moo Young; Lee, Duk-Chul] Yonsei Univ, Coll Med, Dept Family Med, Severance Hosp, Seoul, South Korea.
   [Park, Ki Deok] Gachon Univ Med & Sci, Dept Rehabil Med, Inchon, South Korea.
   [Im, Jee-Aee] INTOTO Inc, Sports & Med Res Ctr, Seoul, South Korea.
C3 Yonsei University; Yonsei University Health System; Gachon University
RP Lee, DC (corresponding author), Yonsei Univ, Coll Med, Dept Family Med, Severance Hosp, Seoul, South Korea.
EM faith@yuhs.ac
RI LEE, Ji/C-2295-2009
OI LEE, JI WON/0000-0002-2666-4249; Lee, Duk Chul/0000-0001-9166-1813
FU Yonsei University College of Medicine
FX This study was supported by a faculty research grant from the Yonsei
   University College of Medicine in 2008. We greatly appreciate the staffs
   of the public health centers in Yangpyung and Ilsan for their efforts in
   recruiting participants. We thank Jae Sung Park and Jeong Ah Hong for
   conducting assessments of cognitive and physical function. We also
   express our appreciation to the research volunteers who participated in
   this study.
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NR 31
TC 62
Z9 72
U1 0
U2 6
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0009-8981
EI 1873-3492
J9 CLIN CHIM ACTA
JI Clin. Chim. Acta
PD APR 2
PY 2010
VL 411
IS 7-8
BP 592
EP 596
DI 10.1016/j.cca.2010.01.024
PG 5
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA 572CB
UT WOS:000275803000023
PM 20114042
DA 2025-06-11
ER

PT J
AU Goldberg, JF
AF Goldberg, Joseph F.
TI PRACTICAL MANAGEMENT STRATEGIES FOR ACUMANIA AND MIXED EPISODES OF
   BIPOLAR DISORDER
SO CNS SPECTRUMS
LA English
DT Article
AB Bipolar disorder is a lifelong condition, which is diagnosed according to corroborative features such as family history, chronobiological sensitivities, treatment outcomes, longitudinal course, and patterns of recurrence. Each illness state is also classified as involving pure mania, hypomania, a mixed episode, a depressed phase, or euthymia. Mixed states are thought to comprise an important subgroup of syndromically ill individuals with bipolar disorder. Several dimensions of psychopathology, including thought-language problems, behavioral disturbances, mood symptoms, and chronobiological changes demand careful evaluation when considering the presentation of a patient with bipolar disorder. Once a comprehensive diagnostic assessment for acute or mixed mania has been completed, it is important to look at an evidence-based data set to guide treatment selection for mood stabilization. Pharmacotherapy is essential to its long-term management of bipolar disorder. Combination therapy, including at least one mood stabilizer, may be necessary to treat acute depression and mania and to further prevent both depressive and manic recurrences. The goal is to minimize frequency, duration, and severity of depressive and manic symptoms with a treatment regimen that is positioned to maximize treatment adherence and minimize side effects. Prevention of mania and maintenance treatment in bipolar disorder is largely routed in the decision to use monotherapy or combination therapy in the treatment regimen. Treatment must also include consideration of comorbidities such as anxiety, substance abuse, cardiovascular disease, and metabolic syndrome, which are pervasive in the bipolar disorder population.
   In this Expert Review Supplement, four experts utilize case presentations to provide insight into the abovementioned topics. Joseph F. Goldberg, MD, addresses diagnostic concepts that may help clinicians accurately identify mixed episodes in patients with bipolar I disorder. Next, Mark A. Frye, MD, reviews treatment guidelines for acute manic and mixed episodes associated with bipolar I disorder as well as the impact of alcohol as an example of drugs of abuse. Charles L. Bowden, MD, reviews prevention of mania and maintenance treatment in bipolar disorder, specifically addressing the ability to weigh efficacy against adverse effects. Finally, Martha Sajatovic, MD, focuses on medical comorbidity and recovery in individuals with bipolar disorder, with particular focus on the medical burden of mania, aging and bipolar disorder, and treatment approaches that promote functional recovery.
C1 Mt Sinai Sch Med, New York, NY 10029 USA.
C3 Icahn School of Medicine at Mount Sinai
RP Goldberg, JF (corresponding author), Mt Sinai Sch Med, New York, NY 10029 USA.
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NR 9
TC 0
Z9 0
U1 0
U2 2
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
SN 1092-8529
EI 2165-6509
J9 CNS SPECTRUMS
JI CNS Spectr.
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PY 2009
VL 14
IS 12
SU 15
BP 4
EP 7
DI 10.1017/S1092852900004016
PG 4
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Psychiatry
GA 547AC
UT WOS:000273856100001
DA 2025-06-11
ER

PT J
AU Abdel-Lateef, MA
   Albalawi, MA
   Al-Ghamdi, SN
   Mahdi, WA
   Alshehri, S
   El Hamd, MA
AF Abdel-Lateef, Mohamed A.
   Albalawi, Marzough Aziz
   Al-Ghamdi, Sameera N.
   Mahdi, Wael A.
   Alshehri, Sultan
   El Hamd, Mohamed A.
TI Determination of metanil yellow dye in turmeric powder using a unique
   fluorescence Europium doped carbon dots
SO SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
LA English
DT Article
DE Curcumin; Carbon dots; Europium; Fluorescence quenching
ID FLUOROMETRIC DETECTION; GREEN SYNTHESIS; AU3+ IONS; CURCUMIN;
   ANTIOXIDANT; CAPSAICIN; FACILE
AB Turmeric, a spice known for its therapeutic benefits, is a major source of curcumin which is a polyphenol with anti-inflammatory properties. It aids in treating arthritis, anxiety, metabolic syndrome, liver disease, hyperlip-idemia, and inflammatory diseases. In this study, a novel fluorescence probe was designed to detect the adul-teration of curcumin by metanil yellow (a harmful artificial dye). The probe was synthesized from the carbonization and conversion of the Tannic acid-Eu3+ complex to bright fluorescence Eu-carbon dots in the presence of orthophosphoric acid. The size, morphological, and optical features of the formed Eu-carbon dots were characterized by UV, SEM, TEM, and FTIR techniques. Furthermore, the formed Eu-carbon dots possess unique fluorescence excitation and emission features at 307.5 nm and 340.6 nm, respectively. These fluorescence features can be successfully quenched upon the addition of metanil yellow dye. The value of quenching in the fluorescence intensity of the Eu-C-dots was directly proportional to the dye's concentration. The LOD value for the proposed method was 0.390 mu g/mL with a linear range of 1.0-15.0 mu g/mL. Furthermore, the methodology exhibited good recovery values for determining the studied dye without any interference from the presence of curcumin.
C1 [Abdel-Lateef, Mohamed A.] Al Azhar Univ, Fac Pharm, Dept Pharmaceut Analyt Chem, Assiut Branch, Assiut 71524, Egypt.
   [Albalawi, Marzough Aziz] Univ Tabuk, Alwajh Coll, Dept Chem, Tabuk 71491, Saudi Arabia.
   [Al-Ghamdi, Sameera N.] Al Baha Univ, Fac Sci, Dept Chem, Al Baha 1988, Saudi Arabia.
   [Mahdi, Wael A.; Alshehri, Sultan] King Saud Univ, Coll Pharm, Dept Pharmaceut, Riyadh 11451, Saudi Arabia.
   [El Hamd, Mohamed A.] Shaqra Univ, Coll Pharm, Dept Pharmaceut Sci, Shaqra 11961, Saudi Arabia.
   [El Hamd, Mohamed A.] South Valley Univ, Fac Pharm, Dept Pharmaceut Analyt Chem, Qena 83523, Egypt.
C3 Egyptian Knowledge Bank (EKB); Al Azhar University; University of Tabuk;
   Al Baha University; King Saud University; Shaqra University; Egyptian
   Knowledge Bank (EKB); South Valley University Egypt
RP Abdel-Lateef, MA (corresponding author), Al Azhar Univ, Fac Pharm, Dept Pharmaceut Analyt Chem, Assiut Branch, Assiut 71524, Egypt.; El Hamd, MA (corresponding author), Shaqra Univ, Coll Pharm, Dept Pharmaceut Sci, Shaqra 11961, Saudi Arabia.
EM mohamed_abdellateef@azhar.edu.eg; maalbalawi@ut.edu.sa;
   snasser@bu.edu.sa; wmahdi@ksu.edu.sa; salshehri1@ksu.edu.sa;
   aboelhamdmohamed@su.edu.sa
RI Alanazi, Saleh/HKN-9388-2023; Abdel-Lateef, mohamed/AEJ-1830-2022; A. El
   Hamd, Mohamed/AAJ-9949-2021; MAHDI, WAEL/ABD-1707-2020; Aziz Albalawi,
   Prof. Marzough/HSF-1320-2023
OI MAHDI, WAEL/0000-0002-7083-1753; Abdel-Lateef,
   mohamed/0000-0002-3020-4966; Aziz Albalawi, Prof.
   Marzough/0000-0003-4579-0045; A. El Hamd, Mohamed/0009-0009-0253-6427
FU King Saud University, Riyadh, Saudi Arabia; Deanship of Scientific
   Research at Shaqra University;  [RSP2022R516]
FX Acknowledgements The authors are thankful to the Researchers Supporting
   Project (number RSP2022R516) at King Saud University, Riyadh, Saudi
   Arabia. The authors would like to thank the Deanship of Scientific
   Research at Shaqra University for supporting this work.
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NR 40
TC 23
Z9 24
U1 5
U2 62
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 1386-1425
EI 1873-3557
J9 SPECTROCHIM ACTA A
JI Spectroc. Acta Pt. A-Molec. Biomolec. Spectr.
PD FEB 15
PY 2023
VL 287
AR 122124
DI 10.1016/j.saa.2022.122124
EA NOV 2022
PN 1
PG 8
WC Spectroscopy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Spectroscopy
GA 7E4NK
UT WOS:000901146700004
PM 36427404
DA 2025-06-11
ER

PT J
AU Espinoza, WPG
   Llanos, AMG
   Ocampo, KKE
   Villareal, JMP
   Cárdenas, VJP
   Zamora, LC
   Flores, MAV
   Arita, AKD
   Gastélum, MA
   Gómez, JAM
AF Espinoza, Wendy P. Gastelum
   Llanos, Alma M. Guadron
   Ocampo, Kenia K. Esparza
   Villareal, Jesus M. Perez
   Cardenas, Veronica J. Picos
   Zamora, Loranda Calderon
   Flores, Marco A. Valdes
   Arita, Alberto K. De la Herran
   Gastelum, Mayra Arias
   Gomez, Javier A. Magana
TI Increased AGEs/sRAGE ratio and dyslipidemia risk in Down syndrome
   youths: a cross-sectional study
SO PEDIATRIC RESEARCH
LA English
DT Article; Early Access
ID GLYCATION END-PRODUCTS; OXIDATIVE/NITROSATIVE STRESS; CARDIOMETABOLIC
   RISK; URINARY BIOMARKERS; SOLUBLE RECEPTORS; CHILDREN; DISEASE; RAGE;
   AGE; ADOLESCENTS
AB BACKGROUND: Down syndrome (DS) is associated with a higher risk of diseases linked to advanced glycation end products (AGEs) accumulation. OBJECTIVE: To evaluate serum AGEs and their soluble receptor (sRAGE) levels in children and adolescents with DS and explore associations with anthropometric and biochemical variables. METHODS: A cross-sectional study compared 51 DS participants (ages 3-18) with an age-matched control group (n = 51). Anthropometric measurements, blood chemistry, and lipid profiles were assessed. AGEs and sRAGE concentrations were determined by fluorescence and ELISA, respectively. RESULTS: DS individuals showed an unfavorable lipid profile, with higher triglycerides and lower HDL-C than controls. AGEs concentrations were significantly elevated in DS compared to controls (2.01 +/- 0.48 vs. 1.33 +/- 0.26 FAU/mu g/mL; p < 0.001), while sRAGE levels were reduced (761.3 +/- 433.7 vs. 1,196 +/- 411.5 pg/mL; p < 0.001). The AGEs/sRAGE ratio was three times higher in the DS group than in controls (3.5 +/- 1.9 vs. 1.2 +/- 0.4; p < 0.001). Regression analysis identified HbA1c as a strong predictor of increased AGEs in both groups. CONCLUSION: Individuals with DS have an increased risk of dyslipidemia. Additionally, the elevated AGEs/sRAGE ratio associated with this genetic condition may reduce the protective effect of sRAGE against inflammatory processes.
C1 [Espinoza, Wendy P. Gastelum; Ocampo, Kenia K. Esparza; Villareal, Jesus M. Perez] Univ Autonoma Sinaloa, Fac Ciencias Quim Biol, Posgrad Ciencias Biomed, Culiacan, Sinaloa, Mexico.
   [Espinoza, Wendy P. Gastelum; Ocampo, Kenia K. Esparza] Univ Autonoma Occidente, Programa Nutr, Culiacan, Sinaloa, Mexico.
   [Llanos, Alma M. Guadron; Cardenas, Veronica J. Picos; Flores, Marco A. Valdes; Arita, Alberto K. De la Herran] Univ Autonoma Sinaloa, Fac Med, Culiacan, Sinaloa, Mexico.
   [Zamora, Loranda Calderon] Univ Autonoma Sinaloa, Fac Biol, Posgrad Ciencias Biol, Culiacan, Sinaloa, Mexico.
   [Gastelum, Mayra Arias; Gomez, Javier A. Magana] Univ Autonoma Sinaloa, Fac Ciencias Nutr & Gastron, Culiacan, Sinaloa, Mexico.
C3 Universidad Autonoma de Sinaloa; Universidad Autonoma de Sinaloa;
   Universidad Autonoma de Sinaloa; Universidad Autonoma de Sinaloa
RP Gómez, JAM (corresponding author), Univ Autonoma Sinaloa, Fac Ciencias Nutr & Gastron, Culiacan, Sinaloa, Mexico.
EM jmagana@uas.edu.mx
RI Arias-Gastelum, Mayra/AAW-2638-2020; DE LA HERRAN,
   ALBERTO/AAU-5975-2020; Mathios Flores, Marco/HPC-6763-2023; Magana
   Gomez, Javier/M-3493-2019
OI Magana Gomez, Javier/0000-0003-1081-6997; DE LA HERRAN-ARITA, ALBERTO
   KOUSUKE/0000-0002-2307-0648; Arias-Gastelum, Mayra/0000-0003-4190-2935;
   Gastelum Espinoza, Wendy P./0000-0002-1946-2550
FU National Council for Humanities, Science, and Technology (CONAHCYT);
   Programa de Fomento y Apoyo a Proyectos de Investigacion (PROFAPI 2022)
   as part of the project titled "Effect of a Health Education Program for
   Individuals with Down syndrome on Their Dietary Quality and Blood
   Metabolic Profile" [PRO_A3_020]
FX The author expresses gratitude to the National Council for Humanities,
   Science, and Technology (CONAHCYT) for the support provided through the
   postgraduate scholarship, which was essential for completing the
   master's degree. Additionally, a heartfelt acknowledgment is extended to
   Dr. Carla Angulo Rojo, whose guidance, wisdom, and generosity were an
   invaluable source of inspiration for this work. This work was funded by
   the Programa de Fomento y Apoyo a Proyectos de Investigacion (PROFAPI
   2022) as part of the project titled "Effect of a Health Education
   Program for Individuals with Down syndrome on Their Dietary Quality and
   Blood Metabolic Profile" (Project Code PRO_A3_020).
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NR 53
TC 0
Z9 0
U1 0
U2 0
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0031-3998
EI 1530-0447
J9 PEDIATR RES
JI Pediatr. Res.
PD 2025 FEB 10
PY 2025
DI 10.1038/s41390-025-03912-6
EA FEB 2025
PG 9
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA W3M6L
UT WOS:001417663500001
PM 39930250
DA 2025-06-11
ER

PT J
AU LeBlanc, AJ
   Hoying, JB
AF LeBlanc, Amanda J.
   Hoying, James B.
TI Adaptation of the Coronary Microcirculation in Aging
SO MICROCIRCULATION
LA English
DT Review
DE plasticity; flow reserve; aging; coronary; vasoreactivity
ID ENDOTHELIUM-DEPENDENT DILATION; NITRIC-OXIDE SYNTHASE; FLOW-INDUCED
   DILATION; CARDIOVASCULAR-DISEASE ENTERPRISES; ACUTE
   MYOCARDIAL-INFARCTION; MUSCLE FEED ARTERIES; CARDIAC SYNDROME-X; CALORIC
   RESTRICTION; OXIDATIVE STRESS; SHEAR-STRESS
AB Advancing age will affect every individual and its impact on health deserves significant attention particularly as we address therapeutic possibilities to pathological conditions. The changes that occur in the coronary vasculature as a result of aging-related senescence set the stage upon which CVD and ischemia can escalate. Because of its importance in health, the consequences of aging on vasculature adaptation must be considered as we identify molecular targets and cell therapies for older patients. To understand the complex relationships between the coronary vasculature and the myocardium, it is important to characterize the unique aged cardiac environment in both locales independent of overlying disease. Therefore, the overall theme of this review is to highlight the biology of aging coronary vasculature and how this promotes a decreased plasticity, exacerbating insults such as ischemia. We will identify potential age-related mechanisms that may contribute to this overall loss of adaptation and regeneration and review potential therapeutic strategies to ameliorate this dysfunction.
C1 [LeBlanc, Amanda J.; Hoying, James B.] Univ Louisville, Dept Physiol, Cardiovasc Innovat Inst, Louisville, KY 40292 USA.
   Cardiovasc Innovat Inst, Louisville, KY 40202 USA.
C3 University of Louisville
RP LeBlanc, AJ (corresponding author), Cardiovasc Innovat Inst, 302 E Muhammad Ali Blvd, Louisville, KY 40202 USA.
EM amanda.leblanc@louisville.edu
OI LeBlanc, Amanda/0000-0003-2507-1203
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NR 136
TC 17
Z9 18
U1 0
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1073-9688
EI 1549-8719
J9 MICROCIRCULATION
JI Microcirculation
PD FEB
PY 2016
VL 23
IS 2
SI SI
BP 157
EP 167
DI 10.1111/micc.12264
PG 11
WC Hematology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Hematology; Cardiovascular System & Cardiology
GA DD6IR
UT WOS:000370028400006
PM 26661273
OA Bronze
DA 2025-06-11
ER

PT J
AU Pacher, P
   Steffens, S
   Haskó, G
   Schindler, TH
   Kunos, G
AF Pacher, Pal
   Steffens, Sabine
   Hasko, Gyorgy
   Schindler, Thomas H.
   Kunos, George
TI Cardiovascular effects of marijuana and synthetic cannabinoids: the
   good, the bad, and the ugly
SO NATURE REVIEWS CARDIOLOGY
LA English
DT Review
ID CARDIOMETABOLIC RISK-FACTORS; CB2 RECEPTOR ACTIVATION;
   TREATMENT-RESISTANT EPILEPSY; ISCHEMIA-REPERFUSION INJURY; ACUTE
   MYOCARDIAL-INFARCTION; MUSCLE-CELL PROLIFERATION;
   CORONARY-ARTERY-DISEASE; ENDOCANNABINOID SYSTEM; CARDIAC DYSFUNCTION;
   OXIDATIVE STRESS
AB Dysregulation of the endogenous lipid mediators endocannabinoids and their G-protein-coupled cannabinoid receptors 1 and 2 (CB1R and CB2R) has been implicated in a variety of cardiovascular pathologies. Activation of CB1R facilitates the development of cardiometabolic disease, whereas activation of CB2R (expressed primarily in immune cells) exerts anti-inflammatory effects. The psychoactive constituent of marijuana,Delta(9)-tetrahydrocannabinol (THC), is an agonist of both CB1R and CB2R, and exerts its psychoactive and adverse cardiovascular effects through the activation of CB1R in the central nervous and cardiovascular systems. The past decade has seen a nearly tenfold increase in the THC content of marijuana as well as the increased availability of highly potent synthetic cannabinoids for recreational use. These changes have been accompanied by the emergence of serious adverse cardiovascular events, including myocardial infarction, cardiomyopathy, arrhythmias, stroke, and cardiac arrest. In this Review, we summarize the role of the endocannabinoid system in cardiovascular disease, and critically discuss the cardiovascular consequences of marijuana and synthetic cannabinoid use. With the legalization of marijuana for medicinal purposes and/or recreational use in many countries, physicians should be alert to the possibility that the use of marijuana or its potent synthetic analogues might be the underlying cause of severe cardiovascular events and pathologies.
C1 [Pacher, Pal] NIAAA, Lab Cardiovasc Physiol & Tissue Injury, NIH, 5625 Fishers Lane, Bethesda, MD 20892 USA.
   [Steffens, Sabine] Ludwig Maximilians Univ Munchen, Inst Cardiovasc Prevent, Pettenkoferstr 8a & 9b, D-80336 Munich, Germany.
   [Steffens, Sabine] German Ctr Cardiovasc Res DZHK, Partner Site Munich Heart Alliance, Pettenkoferstr 8a & 9b, D-80336 Munich, Germany.
   [Hasko, Gyorgy] Rutgers New Jersey Med Sch, Dept Surg, 185 South Orange Ave, Newark, NJ 07103 USA.
   [Schindler, Thomas H.] Johns Hopkins Univ, Dept Radiol, 601 North Caroline St, Baltimore, MD 21287 USA.
   [Kunos, George] NIAAA, Lab Physiol Studies, NIH, 5625 Fishers Lane, Bethesda, MD 20892 USA.
C3 National Institutes of Health (NIH) - USA; NIH National Institute on
   Alcohol Abuse & Alcoholism (NIAAA); University of Munich; German Centre
   for Cardiovascular Research; Munich Heart Alliance; Rutgers University
   System; Rutgers University New Brunswick; Rutgers University Biomedical
   & Health Sciences; Johns Hopkins University; National Institutes of
   Health (NIH) - USA; NIH National Institute on Alcohol Abuse & Alcoholism
   (NIAAA)
RP Pacher, P (corresponding author), NIAAA, Lab Cardiovasc Physiol & Tissue Injury, NIH, 5625 Fishers Lane, Bethesda, MD 20892 USA.
EM pacher@mail.nih.gov
RI Steffens, Sabine/AAV-4551-2020; Pacher, Pal/B-6378-2008
OI Schindler, Thomas Hellmut/0000-0002-2141-7716; Steffens,
   Sabine/0000-0002-6892-9751; Pacher, Pal/0000-0001-7036-8108
FU NIAAA/NIH
FX The authors are supported by the Intramural Program of the NIAAA/NIH.
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NR 242
TC 286
Z9 299
U1 4
U2 146
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 1759-5002
EI 1759-5010
J9 NAT REV CARDIOL
JI Nat. Rev. Cardiol.
PD MAR
PY 2018
VL 15
IS 3
BP 151
EP 166
DI 10.1038/nrcardio.2017.130
PG 16
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Cardiovascular System & Cardiology
GA FW0IF
UT WOS:000424976700011
PM 28905873
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Zalihic, A
   Markotic, V
   Zalihic, D
   Mabic, M
AF Zalihic, Amra
   Markotic, Vedran
   Zalihic, Dino
   Mabic, Mirela
TI GENDER AND QUALITY OF LIFE AFTER CEREBRAL STROKE
SO BOSNIAN JOURNAL OF BASIC MEDICAL SCIENCES
LA English
DT Article
DE gender; cerebral stroke; quality of life
ID SEX-DIFFERENCES; CLINICAL PRESENTATION; MANAGEMENT; REGISTRY; SCALE
AB The aim of this work is to investigate the influence of gender on recovery after cerebral stroke. It is believed that functional outcome of cerebral stroke (CS) depends on gender. Female gender is mildly negative prognostic factor in after stroke results. Two hundred and two patients who had first ischemic cerebral stroke were questioned with help of, H ADS and WHOQOL-Bref questionnaires, looking for differences in recovery depending on gender.
   Average patients' age was 72 +/- 13 (ME +/- IR) years. The youngest patient had 40 years, and the oldest 92 years, and medium range was 52 years. There were 1 12 males and 90 females. Quality of life was equally graded by both male and female after CS (p=0,208). Male patients had significantly better results in physical (p=0,035) and psychological (p=0,020) domain of life quality. After CS, male patients had better results only in memory dimension (p=0,003). Anxiety was statistically more frequent among female patients (p=0,009). Gender did not influence frequency of metabolic syndrome in patients with CS.
   Quality of life after CS was better in male patients, and statistically significant difference has been shown in physical, psychological domain and memory dimension. Female patients were more anxious then male after CS.
C1 [Zalihic, Amra; Markotic, Vedran] Hlth Care Ctr Mostar, Dept Family Med, Mostar 88000, Bosnia & Herceg.
   [Zalihic, Dino] Univ Mostar, Fac Med, Mostar 88000, Bosnia & Herceg.
   [Mabic, Mirela] Univ Mostar, Fac Econ, Mostar 88000, Bosnia & Herceg.
C3 University of Mostar; University of Mostar; University of Mostar
RP Zalihic, A (corresponding author), Hlth Care Ctr Mostar, Dept Family Med, Hrvatskih Branitelja Bb, Mostar 88000, Bosnia & Herceg.
RI Mabic, Mirela/N-8720-2018
OI Mabic, Mirela/0000-0002-1529-7797; Zalihic, Amra/0000-0003-1838-1465
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NR 22
TC 17
Z9 20
U1 2
U2 10
PU ASSOC BASIC MEDICAL SCI FEDERATION BOSNIA & HERZEGOVINA SARAJEVO
PI CEKALUSA
PA UNIV SARAJEVO, MEDICAL FAC, CEKALUSA, SARAJEVO 90, BOSNIA & HERCEG
SN 1512-8601
J9 BOSNIAN J BASIC MED
JI Bosnian J. Basic Med. Sci.
PD MAY
PY 2010
VL 10
IS 2
BP 94
EP 99
DI 10.17305/bjbms.2010.2701
PG 6
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 616HA
UT WOS:000279198500005
PM 20507287
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Sampogna, G
   Luciano, M
   Di Vincenzo, M
   Andriola, I
   D'Ambrosio, E
   Amore, M
   Serafini, G
   Rossi, A
   Carmassi, C
   Dell'Osso, L
   Di Lorenzo, G
   Siracusano, A
   Rossi, R
   Fiorillo, A
   Working Grp LIFESTYLE
AF Sampogna, Gaia
   Luciano, Mario
   Di Vincenzo, Matteo
   Andriola, Ileana
   D'Ambrosio, Enrico
   Amore, Mario
   Serafini, Gianluca
   Rossi, Alessandro
   Carmassi, Claudia
   Dell'Osso, Liliana
   Di Lorenzo, Giorgio
   Siracusano, Alberto
   Rossi, Rodolfo
   Fiorillo, Andrea
   Working Grp LIFESTYLE
TI The Complex Interplay Between Physical Activity and Recovery Styles in
   Patients With Severe Mental Disorders in a Real-World Multicentric Study
SO FRONTIERS IN PSYCHIATRY
LA English
DT Article
DE lifestyle; physical activity; sedentary behaviors; mortality; severe
   mental disorders
ID QUALITY-OF-LIFE; CONSENSUS COGNITIVE BATTERY; BIPOLAR DISORDER; CLINICAL
   CHARACTERIZATION; SCHIZOAFFECTIVE DISORDER; ANTIPSYCHOTIC TREATMENT;
   ACTIVITY PARTICIPATION; NICOTINE DEPENDENCE; SMOKING-CESSATION; EXCESS
   MORTALITY
AB Compared with the general population, people with severe mental disorders have significantly worse physical health and a higher mortality rate, which is partially due to the adoption of unhealthy lifestyle behaviors, such as heavy smoking, use of alcohol or illicit drugs, unbalanced diet, and physical inactivity. These unhealthy behaviors may also play a significant role in the personal and functional recovery of patients with severe mental disorders, although this relationship has been rarely investigated in methodologically robust studies. In this paper, we aim to: a) describe the levels of physical activity and recovery style in a sample of patients with severe mental disorders; b) identify the clinical, social, and illness-related factors that predict the likelihood of patients performing physical activity. The global sample consists of 401 patients, with a main psychiatric diagnosis of bipolar disorder (43.4%, N = 174), psychosis spectrum disorder (29.7%; N = 119), or major depression (26.9%; N = 118). 29.4% (N = 119) of patients reported performing physical activity regularly, most frequently walking (52.1%, N = 62), going to the gym (21.8%, N = 26), and running (10.9%, N = 13). Only 15 patients (3.7%) performed at least 75 min of vigorous physical activity per week. 46.8% of patients adopted sealing over as a recovery style and 37.9% used a mixed style toward integration. Recovery style is influenced by gender (p < 0.05) and age (p < 0.05). The probability to practice regular physical activity is higher in patients with metabolic syndrome (Odds Ratio - OR: 2.1; Confidence Interval - CI 95%: 1.2-3.5; p < 0.050), and significantly lower in those with higher levels of anxiety/depressive symptoms (OR: 0.877; CI 95%: 0.771-0.998; p < 0.01). Globally, patients with severe mental disorders report low levels of physical activities, which are associated with poor recovery styles. Psychoeducational interventions aimed at increasing patients' motivation to adopt healthy lifestyle behaviors and modifying recovery styles may improve the physical health of people with severe mental disorders thus reducing the mortality rates.
C1 [Sampogna, Gaia; Luciano, Mario; Di Vincenzo, Matteo; Fiorillo, Andrea] Univ Campania L Vanvitelli, Dept Psychiat, Naples, Italy.
   [Andriola, Ileana; D'Ambrosio, Enrico] Univ Bari Aldo Moro, Dept Basic Med Sci, Neurosci, Sense Organs, Bari, Italy.
   [Amore, Mario; Serafini, Gianluca] Univ Genoa, Dept Neurosci, Sect Psychiat, Rehabil,Ophthalmology,Genet,Maternal & Child Hlth, Genoa, Italy.
   [Rossi, Alessandro; Rossi, Rodolfo] Univ Aquila, Dept Biotechnol & Appl Clin Sci DISCAB, Laquila, Italy.
   [Carmassi, Claudia; Dell'Osso, Liliana] Univ Pisa, Dept Clin & Expt Med, Psychiat Unit, AOUP, Pisa, Italy.
   [Di Lorenzo, Giorgio; Siracusano, Alberto; Rossi, Rodolfo] Univ Roma Tor Vergata, Dept Syst Med, Rome, Italy.
C3 Universita della Campania Vanvitelli; Universita degli Studi di Bari
   Aldo Moro; University of Genoa; University of L'Aquila; University of
   Pisa; Azienda Ospedaliero Universitaria Pisana; University of Rome Tor
   Vergata
RP Sampogna, G (corresponding author), Univ Campania L Vanvitelli, Dept Psychiat, Naples, Italy.
EM gaia.sampogna@gmail.com
RI Serafini, Gianluca/K-6603-2016; Sampogna, Gaia/AHH-4608-2022; Rodolico,
   Alessandro/GQQ-5888-2022; D'Ambrosio, Enrico/JFJ-8825-2023; Rossi,
   Rodolfo/P-9228-2019; Di Lorenzo, Giorgio/B-1308-2013
OI Selvaggi, Pierluigi/0000-0001-9069-0700; NIOLU,
   CINZIA/0000-0001-6173-2684; Di Vincenzo, Matteo/0009-0008-3517-8905; Di
   Lorenzo, Giorgio/0000-0002-0576-4064; Luciano,
   Mario/0000-0002-4338-1371; Tavella, Angelantonio/0009-0009-8920-5646
FU Italian Ministry of Education, Universities and Research within the
   framework of the Progetti di Rilevante Interesse Nazionale (PRIN)
   [2015C7374S]
FX Funding This work was supported by the Italian Ministry of Education,
   Universities and Research within the framework of the Progetti di
   Rilevante Interesse Nazionale (PRIN) - year 2015 (Grant Number:
   2015C7374S).
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NR 92
TC 6
Z9 6
U1 0
U2 6
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-0640
J9 FRONT PSYCHIATRY
JI Front. Psychiatry
PD JUL 11
PY 2022
VL 13
AR 945650
DI 10.3389/fpsyt.2022.945650
PG 11
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 6J6MY
UT WOS:000886937800001
PM 35898630
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Inglis, A
   Shibin, S
   Ubungen, R
   Farooq, S
   Mata, P
   Thiam, J
   Al-Mohanna, FA
   Collison, KS
AF Inglis, Angela
   Shibin, Sherin
   Ubungen, Rosario
   Farooq, Sarah
   Mata, Princess
   Thiam, Jennifer
   Al-Mohanna, Futwan A.
   Collison, Kate S.
TI Strain and sex-based glucocentric & behavioral differences between
   KK/HlJ and C57BL/6J mice
SO PHYSIOLOGY & BEHAVIOR
LA English
DT Article
DE Physiology; Behavior; Cognition; Insulin tolerance test; C57BL/6J;
   KK/HlJ; KK/AY; Sex-dependent; Social recognition
ID INBRED MOUSE STRAINS; ALZHEIMERS-DISEASE; ANIMAL-MODELS;
   INDIVIDUAL-DIFFERENCES; DIABETIC-NEPHROPATHY; INSULIN SENSITIVITY;
   GENDER-DIFFERENCES; GLUCOSE; RISK; KK
AB Introduction: Small-animal models are the most widely used preclinical model for studying the etiology, pathology and treatment of diabetes, prediabetes and diabetic comorbidities. Diabetic patients are burdened with higher rates of depression, anxiety and cognitive decline due to inadequate control of blood glucose levels, vascular damage and aberrant CNS insulin signaling. The C57BL/6J model is amongst the most widely used mouse model due to its susceptibility to diet-induced obesity (DIO). This strain has also been well-characterized in behavioral research studies. However the C57BL/6J model has a number of limitations: [1] overt fasting hyperglycemia can only be induced by dietary manipulation and/or chemical ablation of the pancreatic beta cells. [2] There is heterogeneity in the obesogenic response to hypercaloric feeding as well as sex-dependent differences, with males being more responsive. The KK inbred strain has been used to study aspects of the metabolic syndrome and prediabetes due to inherent glucose intolerance, hyperinsulinemia and insulin resistance. However KK/HlJ mice are less well-characterized and there have been fewer behavioral studies reported. The aim of this study was to examine differences in male and female glucocentric parameters between KK/HlJ and C57BL/6J mice, and to compare their performance in a variety of standard behavioral tests relating to general, anxiogenic and cognitive paradigms.
   Methods: Strain differences in male and female KK/HlJ and C57BL/6J mouse adiposity, glucose and insulin parameters were studied together with group differences in standard Open Field, Object Recognition, Elevated Plus Maze, Light-Dark Transition, Porsolt test, Marble Burying, Social Recognition and Morris Water Maze tests. Correlations between behavioral variables were analyzed.
   Results and conclusion: In addition to being uniformly larger, hyperinsulinemic and more insulin intolerant than C57BL/6J mice, we observed marked strain and sex-differences in KK/HlJ behavior. KK/HlJ mice exhibited less locomotor and vertical exploratory behavior in comparison to C57BL/6J, whereas object exploration and novel object discrimination were superior in KK/HlJ mice. Female KK/HlJ mice were faster swimmers, whereas the males exhibited greater spatial cognition and place-learning during the MWM test.
C1 [Inglis, Angela; Shibin, Sherin; Ubungen, Rosario; Farooq, Sarah; Mata, Princess; Thiam, Jennifer; Al-Mohanna, Futwan A.; Collison, Kate S.] King Faisal Specialist Hosp & Res Ctr, Dept Cell Biol, POB 3354, Riyadh 11211, Saudi Arabia.
C3 King Faisal Specialist Hospital & Research Center
RP Collison, KS (corresponding author), King Faisal Specialist Hosp & Res Ctr, Dept Cell Biol, POB 3354, Riyadh 11211, Saudi Arabia.
EM kate@kfshrc.edu.sa
RI Inglis, Angela/IXN-5890-2023
OI Inglis, Angela/0009-0008-0756-2707
FU King Faisal Specialist Hospital & Research Centre, Saudi Arabia [2150
   023]
FX We are indebted to Drs. Abdullah Assiri and Falah Almohanna from the
   Comparative Medicine Department, KFSH&RC for their invaluable advice and
   cooperation in conducting the animal experiments. This work was
   supported by .RAC#2150 023, King Faisal Specialist Hospital & Research
   Centre, Saudi Arabia.
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NR 76
TC 6
Z9 6
U1 0
U2 15
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0031-9384
EI 1873-507X
J9 PHYSIOL BEHAV
JI Physiol. Behav.
PD OCT 15
PY 2019
VL 210
AR 112646
DI 10.1016/j.physbeh.2019.112646
PG 16
WC Psychology, Biological; Behavioral Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Behavioral Sciences
GA JB6DN
UT WOS:000488654900016
PM 31400379
DA 2025-06-11
ER

PT J
AU Limketkai, BN
   Hendler, S
   Ting, PS
   Parian, AM
AF Limketkai, Berkeley N.
   Hendler, Steven
   Ting, Peng-sheng
   Parian, Alyssa M.
TI Fecal Microbiota Transplantation for the Critically Ill Patient
SO NUTRITION IN CLINICAL PRACTICE
LA English
DT Review
DE critical illness; diarrhea; fecal microbiota transplantation;
   gastrointestinal microbiome; microbiota
ID CLOSTRIDIUM-DIFFICILE INFECTION; MULTIPLE ORGAN DYSFUNCTION; INTESTINAL
   MICROBIOTA; GUT-MICROBIOME; DIARRHEA; ENTEROCOLITIS; GUIDELINES;
   COLECTOMY; INFUSION; DISEASE
AB The gut microbiome has been implicated in a diversity of diseases, such as irritable bowel syndrome, inflammatory bowel disease, hepatic steatosis, metabolic syndrome, obesity, and anxiety. Current research also suggests the presence of a bidirectional relationship between the composition of the gut microbiome and critical illness. In the critical care setting, multiple factors (eg, use of antibiotics, aberrant nutrition, bloodstream infections, bowel ischemia, and abnormal bowel motility) strongly contribute to intestinal dysbiosis. Conversely, early studies have associated intestinal dysbiosis with worse clinical outcomes in the intensive care unit (ICU), such as infection, organ failure, and mortality. The possibility of intestinal dysbiosis influencing these clinical outcomes has prompted the question of whether microbiome manipulation strategies, such as fecal microbiota transplantation (FMT), may have a role in the management of critical illness. After a literature search of FMT used in the ICU for indications other than Clostridium difficile infections, we found 4 case reports that describe the use of FMT in 5 critically ill patients with systemic inflammatory responses and no clear source of infection. This review discusses the relationship between the gut microbiome and critical illness, early data on the use of FMT in critical care, and safety considerations of FMT in the critically ill and immunocompromised populations.
C1 [Limketkai, Berkeley N.; Hendler, Steven] Stanford Univ, Sch Med, Div Gastroenterol & Hepatol, Stanford, CA 94305 USA.
   [Ting, Peng-sheng; Parian, Alyssa M.] Johns Hopkins Univ, Sch Med, Div Gastroenterol & Hepatol, Baltimore, MD USA.
C3 Stanford University; Johns Hopkins University
RP Limketkai, BN (corresponding author), Stanford Univ, Sch Med, 430 Broadway St,Pavil C,3rd Floor, Redwood City, CA 94063 USA.
EM berkeley.limketkai@gmail.com
OI Parian, Alyssa/0000-0001-9995-7942; Hendler, Steven/0000-0002-7884-5885;
   Ting, Peng-sheng/0000-0003-1581-2354
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NR 47
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Z9 31
U1 2
U2 15
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0884-5336
EI 1941-2452
J9 NUTR CLIN PRACT
JI Nutr. Clin. Pract.
PD FEB
PY 2019
VL 34
IS 1
BP 73
EP 79
DI 10.1002/ncp.10228
PG 7
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA HM6WX
UT WOS:000459619900008
PM 30561131
DA 2025-06-11
ER

PT J
AU Dhingra, R
   He, F
   Saunders, EFH
   Waschbusch, DA
   Pearl, AM
   Bixler, EO
   Greaney, JL
   Swigart, AR
   Al-Shaar, L
   Chinchilli, VM
   Yanosky, JD
   Liao, DP
AF Dhingra, Radha
   He, Fan
   Saunders, Erika F. H.
   Waschbusch, Daniel A.
   Pearl, Amanda M.
   Bixler, Edward O.
   Greaney, Jody L.
   Swigart, Alison R.
   Al-Shaar, Laila
   Chinchilli, Vernon M.
   Yanosky, Jeff D.
   Liao, Duanping
TI Cardiovascular Disease Burden in Persons with Mental Illness: Comparison
   between a U.S. Psychiatry Outpatient Sample and a U.S. General
   Population Sample
SO MENTAL ILLNESS
LA English
DT Article
ID MAJOR DEPRESSIVE DISORDER; BLOOD-PRESSURE; RISK-FACTOR; METABOLIC
   SYNDROME; HEART-DISEASE; ASSOCIATION; ANXIETY; PREVALENCE; CARE;
   HYPERTENSION
AB Background. Cardiovascular disease (CVD) and depression are the leading causes of disability in the U.S. Using electronic health record data, we describe the CVD burden among persons with mental illness enrolled in the Penn State Psychiatry Clinical Assessment and Rating Evaluation System (PCARES) Registry between 2015 and 2020. Methods. CVD burden assessment included prevalence of CVD conditions (any major CVD or individual CVD risk factors), indicated medication prescriptions for CVD risk factors, and mean levels of body mass index (BMI, kg/m(2)), glycosylated hemoglobin (HbA1C, %), glucose (mg/dl), and lipids (mg/dl). We compared the CVD burden between the PCARES sample to a representative sample of adults from the U.S. general population (NHANES 2013-2016) using one-sample chi-square/t-tests for proportions/means. The CVD burden in NHANES participants was adjusted to PCARES age, race, and sex statistics. Results. The PCARES sample (N=3556) had a mean (SE) age of 42.4 (0.3) years and comprised 63.0% women, 85.0% non-Hispanic Caucasians, and 41.0% with major depressive disorder. CVD burden was higher in the PCARES sample compared to NHANES participants for any major CVD (8.6% vs. 4.6%), diabetes (18.4% vs. 10.4%), BMI (30.3 vs. 28.3), HbA1C (6.1 vs. 5.6), cholesterol (185.6 vs. 181.7), triglycerides (153.3 vs. 136.1), and indicated antihypertensive (94.3% vs. 76.9%) and cholesterol-lowering (49.5% vs. 36.7%) medications (Bonferroni-corrected p=0.03 for each outcome). The CVD burden was lower in the PCARES sample compared to NHANES participants for hypertension (45.9% vs. 50.4%), dyslipidemia (43.2% vs. 61.9%), HDL-C (48.4 vs. 41.4), and LDL-C (107.9 vs. 112.0) (Bonferroni-corrected p=0.03 for each outcome). Glucose levels (110.9 vs. 111.9) and indicated antidiabetic medications (87.4% vs. 86.6%) were similar in the two samples (p>0.05). Conclusions. The CVD burden was higher in persons with mental illness compared to the U.S. general population. Integrated mental and physical healthcare services could reduce long-term disability among persons with mental illness.
C1 [Dhingra, Radha; He, Fan; Al-Shaar, Laila; Chinchilli, Vernon M.; Yanosky, Jeff D.; Liao, Duanping] Penn State Coll Med, Penn State Milton S Hershey Med Ctr, Dept Publ Hlth Sci, Hershey, PA 17033 USA.
   [Saunders, Erika F. H.; Waschbusch, Daniel A.; Pearl, Amanda M.; Bixler, Edward O.; Swigart, Alison R.] Penn State Coll Med, Penn State Milton S Hershey Med Ctr, Dept Psychiat & Behav Hlth, Hershey, PA USA.
   [Greaney, Jody L.] Univ Delaware, Dept Hlth Behav & Nutr Sci, Newark, DE 19716 USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE);
   Pennsylvania State University; Penn State Health; Pennsylvania
   Commonwealth System of Higher Education (PCSHE); Pennsylvania State
   University; Penn State Health; University of Delaware
RP Liao, DP (corresponding author), Penn State Coll Med, Penn State Milton S Hershey Med Ctr, Dept Publ Hlth Sci, Hershey, PA 17033 USA.
EM radha.dhingra@duke.edu; fanhe@psu.edu;
   esaunders@pennstatehealth.psu.edu; dwaschbusch@pennstatehealth.psu.edu;
   amadapearlphd@gmail.com; ebixler@pennstatehealth.psu.edu;
   jgreaney@udel.edu; aswigart@pennstatehealth.psu.edu; lshaar83@gmail.com;
   vchinchilli@pennstatehealth.psu.edu; jyanosky@pennstatehealth.psu.edu;
   dliao@psu.edu
RI Waschbusch, Dan/AAQ-9570-2020; Saunders, Erika/J-4964-2013; Waschbusch,
   Daniel/B-6433-2013
OI Dhingra, Radha/0000-0003-1921-9136; Greaney, Jody/0000-0002-9855-3978;
   Saunders, Erika/0000-0001-7222-0828; Waschbusch,
   Daniel/0000-0002-8115-1286
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NR 90
TC 0
Z9 0
U1 0
U2 1
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2036-7457
EI 2036-7465
J9 MENT ILLN
JI Ment. Illn.
PD MAR 28
PY 2024
VL 2024
AR 1689172
DI 10.1155/2024/1689172
PG 11
WC Psychiatry
WE Emerging Sources Citation Index (ESCI)
SC Psychiatry
GA NB5R9
UT WOS:001198000500001
OA gold
DA 2025-06-11
ER

PT J
AU Hanczyk, E
   Piecuch, D
   Kopcial, S
   Jonska-Gmyrek, J
AF Hanczyk, Edyta
   Piecuch, Dawid
   Kopcial, Szymon
   Jonska-Gmyrek, Joanna
TI Factors Affecting the Effectiveness of DIBH (Deep Inspiratory Breath
   Hold) in Patients with Left Breast Cancer: A Narrative Review
SO APPLIED SCIENCES-BASEL
LA English
DT Review
DE Deep Inspiratory Breath Hold (DIBH); left breast cancer radiotherapy;
   organ sparing methods
ID LEFT-SIDED BREAST; RADIOTHERAPY; THERAPY
AB Deep Inspiratory Breath Hold (DIBH) has become a valuable technique in left-breast cancer radiotherapy, offering the possibility to reduce radiation exposure to organs at risks (OARs) and minimize the risk of cardiac complications. This treatment method involves stopping the breathing of patients during irradiation in order to temporarily distance the heart from the radiation field, which reduces potential cardiac risks and other complications. To identify factors that may affect the effectiveness of DIBH treatment, we analyzed the most important 5-year studies published in the PubMed database. Research shows that DIBH reduces the radiation dose to the heart and lungs. However, the effectiveness of DIBH is determined by a variety of factors, including the patient's training, cooperation, anatomical features, age, and choice of radiotherapy technique. Additionally, cardiovascular risk factors, such as diabetes, smoking, and hypertension, can be impactful to the effectiveness and potential complications of DIBH. Moreover, if a patient has a substantial level of depression or anxiety, then they may be potentially disqualified from the DIBH treatment method. In addition to this, a lack of consent and/or fear may also disqualify a patient from DIBH treatment. Careful patient selection, comprehensive training, and optimization of treatment parameters are essential to maximize the benefits of DIBH whilst minimizing any potential side effects. DIBH enhancement techniques, such as IMRT and VMAT, also have an important role to play. The purpose of this narrative review article is to summarize the factors affecting the efficacy and side effects of DIBH in radiation therapy for left-breast cancer, with the aim of optimizing its clinical application while minimizing side effects. Patients who are likely to benefit most from DIBH are young women in good medical condition, able to cooperate with the procedure, and with smaller breasts. The increase in the estimated 10-year patient survival is significantly influenced by cardiovascular problems, so patients without diabetes and metabolic syndrome, and non-smokers, will benefit the most. An estimated 50-70% of breast cancer patients are likely to benefit from DIBH, and in the best case, it can result in a 50% reduction in the risk of cardiac problems after photodynamic therapy (PDT).
C1 [Hanczyk, Edyta; Piecuch, Dawid; Kopcial, Szymon] Univ Radom, Fac Med, PL-26600 Radom, Poland.
   [Jonska-Gmyrek, Joanna] Univ Radom, Fac Med & Hlth Sci, PL-26600 Radom, Poland.
C3 Kazimierz Pulaski University of Technology & Humanities in Radom;
   Kazimierz Pulaski University of Technology & Humanities in Radom
RP Jonska-Gmyrek, J (corresponding author), Univ Radom, Fac Med & Hlth Sci, PL-26600 Radom, Poland.
EM edyta.hanczyk25@gmail.com; dawsid1999@gmail.com;
   szymon.kopcial@gmail.com; jonska@wp.pl
OI Piecuch, Dawid/0009-0006-8074-0122; Kopcial, Szymon/0009-0008-6647-247X;
   Hanczyk, Edyta/0009-0003-2769-943X
FX This research received no external funding.
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NR 43
TC 0
Z9 0
U1 7
U2 7
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3417
J9 APPL SCI-BASEL
JI Appl. Sci.-Basel
PD AUG
PY 2024
VL 14
IS 16
AR 7287
DI 10.3390/app14167287
PG 14
WC Chemistry, Multidisciplinary; Engineering, Multidisciplinary; Materials
   Science, Multidisciplinary; Physics, Applied
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Engineering; Materials Science; Physics
GA E7X2N
UT WOS:001305089800001
OA gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Hung, CF
   Breen, G
   Czamara, D
   Corre, T
   Wolf, C
   Kloiber, S
   Bergmann, S
   Craddock, N
   Gill, M
   Holsboer, F
   Jones, L
   Jones, I
   Korszun, A
   Kutalik, Z
   Lucae, S
   Maier, W
   Mors, O
   Owen, MJ
   Rice, J
   Rietschel, M
   Uher, R
   Vollenweider, P
   Waeber, G
   Craig, IW
   Farmer, AE
   Lewis, CM
   Müller-Myhsok, B
   Preisig, M
   McGuffin, P
   Rivera, M
AF Hung, Chi-Fa
   Breen, Gerome
   Czamara, Darina
   Corre, Tanguy
   Wolf, Christiane
   Kloiber, Stefan
   Bergmann, Sven
   Craddock, Nick
   Gill, Michael
   Holsboer, Florian
   Jones, Lisa
   Jones, Ian
   Korszun, Ania
   Kutalik, Zoltan
   Lucae, Susanne
   Maier, Wolfgang
   Mors, Ole
   Owen, Michael J.
   Rice, John
   Rietschel, Marcella
   Uher, Rudolf
   Vollenweider, Peter
   Waeber, Gerard
   Craig, Ian W.
   Farmer, Anne E.
   Lewis, Cathryn M.
   Mueller-Myhsok, Bertram
   Preisig, Martin
   McGuffin, Peter
   Rivera, Margarita
TI A genetic risk score combining 32 SNPs is associated with body mass
   index and improves obesity prediction in people with major depressive
   disorder
SO BMC MEDICINE
LA English
DT Article
DE Body mass index; Genetic risk score; Major depressive disorder; Obesity
ID GENOME-WIDE ASSOCIATION; RECURRENT DEPRESSION; METABOLIC SYNDROME; US
   ADULTS; POPULATION; METHODOLOGY; HEALTH; TRENDS; UK
AB Background: Obesity is strongly associated with major depressive disorder (MDD) and various other diseases. Genome-wide association studies have identified multiple risk loci robustly associated with body mass index (BMI). In this study, we aimed to investigate whether a genetic risk score (GRS) combining multiple BMI risk loci might have utility in prediction of obesity in patients with MDD.
   Methods: Linear and logistic regression models were conducted to predict BMI and obesity, respectively, in three independent large case-control studies of major depression (Radiant, GSK-Munich, PsyCoLaus). The analyses were first performed in the whole sample and then separately in depressed cases and controls. An unweighted GRS was calculated by summation of the number of risk alleles. A weighted GRS was calculated as the sum of risk alleles at each locus multiplied by their effect sizes. Receiver operating characteristic (ROC) analysis was used to compare the discriminatory ability of predictors of obesity.
   Results: In the discovery phase, a total of 2,521 participants (1,895 depressed patients and 626 controls) were included from the Radiant study. Both unweighted and weighted GRS were highly associated with BMI (P < 0.001) but explained only a modest amount of variance. Adding 'traditional' risk factors to GRS significantly improved the predictive ability with the area under the curve (AUC) in the ROC analysis, increasing from 0.58 to 0.66 (95% CI, 0.62-0.68; chi(2) = 27.68; P < 0.0001). Although there was no formal evidence of interaction between depression status and GRS, there was further improvement in AUC in the ROC analysis when depression status was added to the model (AUC = 0.71; 95% CI, 0.68-0.73; chi(2) = 28.64; P < 0.0001). We further found that the GRS accounted for more variance of BMI in depressed patients than in healthy controls. Again, GRS discriminated obesity better in depressed patients compared to healthy controls. We later replicated these analyses in two independent samples (GSK-Munich and PsyCoLaus) and found similar results.
   Conclusions: A GRS proved to be a highly significant predictor of obesity in people with MDD but accounted for only modest amount of variance. Nevertheless, as more risk loci are identified, combining a GRS approach with information on non-genetic risk factors could become a useful strategy in identifying MDD patients at higher risk of developing obesity.
C1 [Hung, Chi-Fa; Breen, Gerome; Uher, Rudolf; Craig, Ian W.; Farmer, Anne E.; Lewis, Cathryn M.; McGuffin, Peter; Rivera, Margarita] Kings Coll London, MRC SGDP Ctr, Inst Psychiat Psychol & Neurosci, Box PO82,De Crespigny Pk,Denmark Hill, London SE5 8AF, England.
   [Hung, Chi-Fa] Kaohsiung Chang Gung Mem Hosp, Dept Psychiat, Kaohsiung 833, Taiwan.
   [Hung, Chi-Fa] Chang Gung Univ, Univ Coll Med, Kaohsiung 833, Taiwan.
   [Breen, Gerome; Rivera, Margarita] Kings Coll London, Biomed Res Ctr Mental Hlth Maudsley, Natl Inst Hlth Res, London SE5 8AF, England.
   [Breen, Gerome; Rivera, Margarita] Kings Coll London, Inst Psychiat, London SE5 8AF, England.
   [Czamara, Darina; Wolf, Christiane; Kloiber, Stefan; Holsboer, Florian; Lucae, Susanne; Mueller-Myhsok, Bertram] Max Planck Inst Psychiat, D-80804 Munich, Germany.
   [Corre, Tanguy; Bergmann, Sven; Kutalik, Zoltan] Univ Vaudois, Ctr Hosp, Inst Social & Prevent Med IUMSP, CH-1010 Lausanne, Switzerland.
   [Corre, Tanguy; Bergmann, Sven; Kutalik, Zoltan] Swiss Inst Bioinformat, CH-1015 Lausanne, Switzerland.
   [Craddock, Nick; Jones, Ian] Cardiff Univ, MRC Ctr Neuropsychiat Genet & Genom, Cardiff CF24 4HQ, S Glam, Wales.
   [Gill, Michael] Trinity Ctr Hlth Sci, Dept Psychiat, Dublin 8, Ireland.
   [Jones, Lisa] Univ Birmingham, Sch Clin & Expt Med, Dept Psychiat, Birmingham B15 2TT, W Midlands, England.
   [Korszun, Ania] Queen Marys Univ London, Barts & London Sch Med & Dent, London E1 2AD, England.
   [Maier, Wolfgang] Univ Bonn, Dept Psychiat, D-53127 Bonn, Germany.
   [Mors, Ole] Aarhus Univ Hosp, Res Dept P, iPSYCH, DK-8240 Risskov, Denmark.
   [Owen, Michael J.] Cardiff Univ, MRC Ctr Neuropsychiat Genet & Gen, Sch Med, Dept Psychol Med & Neurol, Cardiff CF14 4XN, S Glam, Wales.
   [Rice, John] Washington Univ, Sch Med, Dept Psychiat, St Louis, MO 63130 USA.
   [Rietschel, Marcella] Cent Inst Mental Hlth, D-68159 Mannheim, Germany.
   [Uher, Rudolf] Dalhousie Univ, Dept Psychiat, Halifax, NS B3H 3J5, Canada.
   [Vollenweider, Peter; Waeber, Gerard] CHU Vaudois, Div Internal Med, CH-1011 Lausanne, Switzerland.
   [Lewis, Cathryn M.] Kings Coll London, Guys Hosp, Sch Med, Dept Med & Mol Genet, London SE1 9RT, England.
   [Preisig, Martin] Univ Lausanne Hosp, Dept Psychiat, CH-1008 Prilly, Switzerland.
   [Rivera, Margarita] Univ Granada, CIBERSAM, Armilla Granada 18100, Spain.
   [Rivera, Margarita] Univ Granada, Ctr Invest Biomed, Inst Neurosci Federico Oloriz, Armilla Granada 18100, Spain.
   [Rivera, Margarita] Univ Granada, Hosp Univ Granada, Inst Invest Biosanit Ibs GRANAD, Granada 18012, Spain.
C3 University of London; King's College London; Chang Gung Memorial
   Hospital; Chang Gung University; University of London; King's College
   London; University of London; King's College London; Max Planck Society;
   Swiss Institute of Bioinformatics; Cardiff University; Trinity College
   Dublin; University of Birmingham; University of London; Queen Mary
   University London; University of Bonn; Lundbeck Foundation Initiative
   for Integrative Psychiatric Research (iPSYCH); Aarhus University;
   Cardiff University; Washington University (WUSTL); Central Institute of
   Mental Health; Dalhousie University; University of Lausanne; Centre
   Hospitalier Universitaire Vaudois (CHUV); Guy's & St Thomas' NHS
   Foundation Trust; University of London; King's College London;
   University of Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV);
   CIBER - Centro de Investigacion Biomedica en Red; CIBERSAM; University
   of Granada; University of Granada; University of Granada
RP Rivera, M (corresponding author), Kings Coll London, MRC SGDP Ctr, Inst Psychiat Psychol & Neurosci, Box PO82,De Crespigny Pk,Denmark Hill, London SE5 8AF, England.
EM margarita.rivera_sanchez@kcl.ac.uk
RI Kloiber, Stefan/AAW-8786-2021; Craig, Ian/AAF-9167-2019; Müller-Myhsok,
   Bertram/A-3289-2013; Kutalik, Zoltan/HHZ-5697-2022; Preisig,
   Martin/H-3441-2016; Lewis, Cathryn/M-8766-2019; McGuffin,
   Peter/A-1565-2012; Maier, Wolfgang/AAB-7317-2021; Jones,
   Ian/B-4925-2009; Lewis, Cathryn/A-5225-2010; Breen, Gerome/A-5540-2010;
   Rivera, Margarita/J-3017-2017; Vollenweider, Peter/Q-4603-2016; Uher,
   Rudolf/A-5477-2008
OI Kloiber, Stefan/0000-0002-6838-4114; Gill, Michael/0000-0003-0206-5337;
   Lewis, Cathryn/0000-0002-8249-8476; Breen, Gerome/0000-0003-2053-1792;
   Rivera, Margarita/0000-0003-4717-1045; Waeber,
   Gerard/0000-0003-4193-788X; Vollenweider, Peter/0000-0002-0765-896X;
   Mors, Ole/0000-0002-5660-0393; Bergmann, Sven/0000-0002-6785-9034; Uher,
   Rudolf/0000-0002-2998-0546; Preisig, Martin/0000-0001-5689-4259;
   Kutalik, Zoltan/0000-0001-8285-7523; Jones, Lisa/0000-0002-5122-8334
FU Pfizer; Eli Lilly; Lundbeck; Medical Research Council, UK [G0701420];
   Medical Research Centre; European Commission; EC [LSHB-CT-2003-503428];
   National Institute for Health Research (NIHR) Biomedical Research Centre
   at South London; Maudsley NHS Foundation Trust; King's College London;
   Swiss National Science Foundation [32003B-105993, 32003B-118308,
   33CSC0-122661, 139468]; Faculty of Biology and Medicine of Lausanne;
   GlaxoSmithKline Clinical Genetics; MRC [G0701420] Funding Source: UKRI;
   Swiss National Science Foundation (SNF) [33CSC0-122661] Funding Source:
   Swiss National Science Foundation (SNF)
FX AEF and PM have received consultancy fees and honoraria for
   participating in expert panels for pharmaceutical companies including
   GlaxoSmithKline. PM has received speaker's fees from Pfizer. FH is
   cofounder of the biotech company HolsboerMaschmeyerNeuroChemie GmbH
   (HMNC GmbH) in Germany. WM is member of the Advisory Board or has
   received speaker fees from Eli Lilly and Lundbeck. MP is part of the
   advisory boards for Eli Lilly and Lundbeck. All other authors declare no
   competing interests. This study was funded by the Medical Research
   Council, UK GlaxoSmithKline (G0701420) funded the DeNT study and were
   co-funders with the Medical Research Centre for the GWAS of the whole
   sample. The GENDEP study was funded by a European Commission Framework 6
   grant, EC Contract Ref.: LSHB-CT-2003-503428. This study presents
   independent research [part-] funded by the National Institute for Health
   Research (NIHR) Biomedical Research Centre at South London and Maudsley
   NHS Foundation Trust and King's College London. The views expressed are
   those of the author(s) and not necessarily those of the NHS, the NIHR,
   or the Department of Health. The CoLaus/PsyCoLaus was funded by four
   grants from the Swiss National Science Foundation (#32003B-105993,
   #32003B-118308, #33CSC0-122661, and #139468), the Faculty of Biology and
   Medicine of Lausanne, and two grants from GlaxoSmithKline Clinical
   Genetics.
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NR 29
TC 53
Z9 60
U1 0
U2 14
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1741-7015
J9 BMC MED
JI BMC Med.
PD APR 17
PY 2015
VL 13
AR 86
DI 10.1186/s12916-015-0334-3
PG 10
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA CG4LR
UT WOS:000353257600001
PM 25903154
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Tommasi, S
   Besaratinia, A
AF Tommasi, Stella
   Besaratinia, Ahmad
TI DNA Hydroxymethylation at the Interface of the Environment and
   Nonalcoholic Fatty Liver Disease
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Review
DE epigenetics; xenobiotics; NAFLD; steatosis; oxidative stress
ID METHYLATION PATTERNS; OXIDATIVE STRESS; GUT MICROBIOTA; TET PROTEINS;
   5-HYDROXYMETHYLCYTOSINE; 5-METHYLCYTOSINE; MECHANISMS; ASSOCIATION;
   METHYLOME; GENOME
AB Non-alcoholic fatty liver disease (NAFLD) is one of the most prevalent forms of chronic liver disorders among adults, children, and adolescents, and a growing epidemic, worldwide. Notwithstanding the known susceptibility factors for NAFLD, i.e., obesity and metabolic syndrome, the exact cause(s) of this disease and the underlying mechanisms of its initiation and progression are not fully elucidated. NAFLD is a multi-faceted disease with metabolic, genetic, epigenetic, and environmental determinants. Accumulating evidence shows that exposure to environmental toxicants contributes to the development of NAFLD by promoting mitochondrial dysfunction and generating reactive oxygen species in the liver. Imbalances in the redox state of the cells are known to cause alterations in the patterns of 5-hydroxymethylcytosine (5hmC), the oxidative product of 5-methylcytosine (5mC), thereby influencing gene regulation. The 5hmC-mediated deregulation of genes involved in hepatic metabolism is an emerging area of research in NAFLD. This review summarizes our current knowledge on the interactive role of xenobiotic exposure and DNA hydroxymethylation in the pathogenesis of fatty liver disease. Increasing the mechanistic knowledge of NAFLD initiation and progression is crucial for the development of new and effective strategies for prevention and treatment of this disease.
C1 [Tommasi, Stella; Besaratinia, Ahmad] Univ Southern Calif, Keck Sch Med, Dept Prevent Med, M-C 9603, Los Angeles, CA 90033 USA.
C3 University of Southern California
RP Tommasi, S (corresponding author), Univ Southern Calif, Keck Sch Med, Dept Prevent Med, M-C 9603, Los Angeles, CA 90033 USA.
EM tommasi@med.usc.edu
RI Tommasi, Stella/NDR-9208-2025
OI Tommasi, Stella/0000-0001-6897-4985; Besaratinia,
   Ahmad/0000-0001-7231-228X
FU National Institute of Dental and Craniofacial Research of the National
   Institutes of Health [1R01DE026043]; University of California
   Tobacco-Related Disease Research Program [TRDRP-25IP-0001,
   TRDRP-26IP-0051, TRDRP-28IR-0058]
FX Work of the authors is supported by grants from the National Institute
   of Dental and Craniofacial Research of the National Institutes of Health
   (1R01DE026043 to AB) and the University of California Tobacco-Related
   Disease Research Program (TRDRP-25IP-0001 and TRDRP-26IP-0051 to ST and
   TRDRP-28IR-0058 to AB).
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NR 95
TC 10
Z9 10
U1 0
U2 14
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-7827
EI 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD AUG 1
PY 2019
VL 16
IS 15
AR 2791
DI 10.3390/ijerph16152791
PG 12
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA IS4MU
UT WOS:000482128400160
PM 31387232
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Aguilar, EC
   da Silva, JF
   Navia-Pelaez, JM
   Leonel, AJ
   Lopes, LG
   Menezes-Garcia, Z
   Ferreira, AVM
   Capettini, LDA
   Teixeira, LG
   Lemos, VS
   Alvarez-Leite, JI
AF Aguilar, Edenil Costa
   da Silva, Josiane Fernandes
   Navia-Pelaez, Juliana Maria
   Leonel, Alda Jusceline
   Lopes, Lorrayne Goncalves
   Menezes-Garcia, Zelia
   Matos Ferreira, Adaliene Versiani
   Aggum Capettini, Luciano dos Santos
   Teixeira, Lilian G.
   Lemos, Virginia Soares
   Alvarez-Leite, Jacqueline I.
TI Sodium butyrate modulates adipocyte expansion, adipogenesis, and insulin
   receptor signaling by upregulation of PPAR-γ in obese Apo E knockout
   mice
SO NUTRITION
LA English
DT Article
DE Sodium butyrate; Obesity; Insulin signaling; Adipokines; Glucose
   homeostasis; Angiogenesis
ID CHAIN FATTY-ACIDS; OXIDATIVE STRESS; EPITHELIAL-CELLS; RESISTANCE;
   INFLAMMATION; INVOLVEMENT; MICROBIOTA; INHIBITOR; SUBSTRATE; MMP-2
AB Objectives: Studies suggest that sodium butyrate reduces obesity-associated inflammation and insulin resistance in in vitro and in vivo models. Apo E-/- mice have high basal oxidative stress and naturally develop dyslipidemia and atherosclerosis. Because these disorders are present in obesity, the aim of this study was to determine whether Apo E-/- mice could be a more realistic model for studying obesity and insulin resistance.
   Methods: We evaluated the action of orally administered sodium butyrate on adipose tissue expansion and insulin resistance using diet-induced obese Apo E-/- mice.
   Results: Findings from the present study demonstrated that obese mice fed a sodium butyrate supplemented diet presented a modest reduction of weight gain associated with reduction of adipocyte expansion, induction of adipogenesis and angiogenesis, and adiponectin production. Sodium butyrate also improved insulin sensitivity, by increasing insulin receptor expression associated with activation of Akt signaling pathway. These results were associated with increased peroxisome proliferator-activated receptor-gamma expression and nuclear factor-kappa B downregulation.
   Conclusion: These results suggested that oral supplementation of butyrate could be useful as an adjuvant in the treatment of obesity, metabolic syndrome, and insulin resistance. (C) 2017 Elsevier Inc. All rights reserved.
C1 [Aguilar, Edenil Costa; Leonel, Alda Jusceline; Lopes, Lorrayne Goncalves; Teixeira, Lilian G.; Alvarez-Leite, Jacqueline I.] Univ Fed Minas Gerais, Dept Bioquim & Imunol, Belo Horizonte, MG, Brazil.
   [Aguilar, Edenil Costa; da Silva, Josiane Fernandes; Menezes-Garcia, Zelia; Lemos, Virginia Soares] Univ Fed Minas Gerais, Dept Fisiol, Belo Horizonte, MG, Brazil.
   [Navia-Pelaez, Juliana Maria; Aggum Capettini, Luciano dos Santos] Univ Fed Minas Gerais, Dept Farmacol, Belo Horizonte, MG, Brazil.
   [Matos Ferreira, Adaliene Versiani] Univ Fed Minas Gerais, Dept Nutr, Belo Horizonte, MG, Brazil.
C3 Universidade Federal de Minas Gerais; Universidade Federal de Minas
   Gerais; Universidade Federal de Minas Gerais; Universidade Federal de
   Minas Gerais
RP Alvarez-Leite, JI (corresponding author), Univ Fed Minas Gerais, Dept Bioquim & Imunol, Belo Horizonte, MG, Brazil.
EM Jalvarezleite@gmail.com
RI Silva, Josiane/AAM-9261-2020; Navia-Pelaez, Juliana/AAD-6973-2022;
   Teixeira, Lílian/CAI-1620-2022; Lemos, Virginia/B-7305-2018; Ferreira,
   adaliene/G-8523-2011; ALVAREZ-LEITE, JACQUELINE/C-9175-2014
OI Capettini, Luciano/0000-0002-6487-9558; Menezes-Garcia,
   Zelia/0000-0002-1600-0289; Silva, Josiane/0000-0002-6623-7946;
   Navia-Pelaez, Juliana M/0000-0001-5709-339X; Ferreira,
   adaliene/0000-0003-2256-8652; ALVAREZ-LEITE,
   JACQUELINE/0000-0001-6601-9853
FU CNPq (Conselho Nacional de Desenvolvimento Cientifico e Tecnologico);
   Pro-reitoria de Pesquisa (PRPq) of Universidade Federal de Minas
   Gerais); FAPEMIG (Fundacao de Amparo a Pesquisa de Minas Gerais); CAPES
   (Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior)
FX This work was supported by CNPq (Conselho Nacional de Desenvolvimento
   Cientifico e Tecnologico), Pro-reitoria de Pesquisa (PRPq) of
   Universidade Federal de Minas Gerais), FAPEMIG (Fundacao de Amparo a
   Pesquisa de Minas Gerais), and CAPES (Coordenacao de Aperfeicoamento de
   Pessoal de Nivel Superior). The authors have no conflicts of interest to
   declare.
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NR 42
TC 49
Z9 55
U1 2
U2 11
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0899-9007
EI 1873-1244
J9 NUTRITION
JI Nutrition
PD MAR
PY 2018
VL 47
BP 75
EP 82
DI 10.1016/j.nut.2017.10.007
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA FX6WQ
UT WOS:000426228400013
PM 29429540
DA 2025-06-11
ER

PT J
AU Cao, K
   Xu, J
   Pu, WJ
   Dong, ZZ
   Sun, L
   Zang, WJ
   Gao, F
   Zhang, Y
   Feng, ZH
   Liu, JK
AF Cao, Ke
   Xu, Jie
   Pu, Wenjun
   Dong, Zhizhong
   Sun, Lei
   Zang, Weijin
   Gao, Feng
   Zhang, Yong
   Feng, Zhihui
   Liu, Jiankang
TI Punicalagin, an active component in pomegranate, ameliorates cardiac
   mitochondrial impairment in obese rats via AMPK activation
SO SCIENTIFIC REPORTS
LA English
DT Article
ID OXIDATIVE STRESS; PROTEIN-KINASE; SKELETAL-MUSCLE; HEART; DIET;
   BIOGENESIS; EXPRESSION; FIBROSIS; JUICE; HYPERGLYCEMIA
AB Obesity is associated with an increasing prevalence of cardiovascular diseases and metabolic syndrome. It is of paramount importance to reduce obesity-associated cardiac dysfunction and impaired energy metabolism. In this study, the activation of the AMP-activated protein kinase (AMPK) pathway by punicalagin (PU), a major ellagitannin in pomegranate was investigated in the heart of a rat obesity model. In male SD rats, eight-week administration of 150 mg/kg pomegranate extract (PE) containing 40% punicalagin sufficiently prevented high-fat diet (HFD)-induced obesity associated accumulation of cardiac triglyceride and cholesterol as well as myocardial damage. Concomitantly, the AMPK pathway was activated, which may account for prevention of mitochondrial loss via upregulating mitochondrial biogenesis and amelioration of oxidative stress via enhancing phase II enzymes in the hearts of HFD rats. Together with the normalized expression of uncoupling proteins and mitochondrial dynamic regulators, PE significantly prevented HFD-induced cardiac ATP loss. Through in vitro cultures, we showed that punicalagin was the predominant component that activated AMPK by quickly decreasing the cellular ATP/ADP ratio specifically in cardiomyocytes. Our findings demonstrated that punicalagin, the major active component in PE, could modulate mitochondria and phase II enzymes through AMPK pathway to prevent HFD-induced cardiac metabolic disorders.
C1 [Cao, Ke; Xu, Jie; Pu, Wenjun; Zhang, Yong; Feng, Zhihui; Liu, Jiankang] Xi An Jiao Tong Univ, Frontier Inst Sci & Technol, Ctr Mitochondrial Biol & Med, Xian 710049, Peoples R China.
   [Cao, Ke; Xu, Jie; Pu, Wenjun; Zhang, Yong; Feng, Zhihui; Liu, Jiankang] Xi An Jiao Tong Univ, Sch Life Sci & Technol, Minist Educ, Key Lab Biomed Informat Engn, Xian 710049, Peoples R China.
   [Dong, Zhizhong] Nestle Res Ctr Beijing, Beijing 100095, Peoples R China.
   [Sun, Lei; Zang, Weijin] Xi An Jiao Tong Univ, Sch Med, Dept Pharmacol, Xian 710049, Peoples R China.
   [Gao, Feng] Fourth Mil Med Univ, Dept Aerosp Med, Xian 710032, Peoples R China.
   [Zhang, Yong; Liu, Jiankang] Tianjin Univ Sport, Tianjin Key Lab Exercise Physiol & Sports Med, Tianjin 300381, Peoples R China.
C3 Xi'an Jiaotong University; Xi'an Jiaotong University; Ministry of
   Education - China; Xi'an Jiaotong University; Air Force Medical
   University; Tianjin University of Sport
RP Feng, ZH (corresponding author), Xi An Jiao Tong Univ, Frontier Inst Sci & Technol, Ctr Mitochondrial Biol & Med, Xian 710049, Peoples R China.
EM zhfeng@mail.xjtu.edu.cn; j.liu@mail.xjtu.edu.cn
RI lei, sun/HGE-2755-2022; Liu, Jiankang/A-1610-2011; Gao,
   Feng/X-4385-2019; Xu, Jie/MNP-4744-2025; Pu, Wenjun/AAI-2207-2019; Feng,
   Zhihui/E-7408-2011
OI Gao, Feng/0000-0001-6555-1717; Feng, Zhihui/0000-0002-2448-6565
FU National Basic Research Program [2015CB553602, 2014CB548200]; Tianjin
   Science and Technology Planning Major Project [12JCZDJC34400]; Tianjin
   Education committee Sci-Tech Development Major Project [20112D05];
   Tianjin Key Labs and Tech-Platform Project [10SYSYJC28400]; National
   Natural Science Foundation of China [81201023]
FX This study was supported by the National Basic Research Program (No.
   2015CB553602, No. 2014CB548200), Tianjin Science and Technology Planning
   Major Project (12JCZDJC34400), Tianjin Education committee Sci-Tech
   Development Major Project (20112D05), Tianjin Key Labs and Tech-Platform
   Project (10SYSYJC28400), and the National Natural Science Foundation of
   China (81201023).
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NR 48
TC 80
Z9 84
U1 0
U2 42
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD SEP 15
PY 2015
VL 5
AR 14014
DI 10.1038/srep14014
PG 12
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA CR2QK
UT WOS:000361175200001
PM 26369619
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Payne, GA
   Kohr, MC
   Tune, JD
AF Payne, Gregory A.
   Kohr, Meredith C.
   Tune, Johnathan D.
TI Epicardial perivascular adipose tissue as a therapeutic target in
   obesity-related coronary artery disease
SO BRITISH JOURNAL OF PHARMACOLOGY
LA English
DT Review
DE perivascular adipose tissue; epicardial adipose tissue; endothelial
   dysfunction; leptin; adiponectin; adipokines; coronary artery disease;
   coronary circulation; inflammation; obesity
ID VISCERAL ABDOMINAL FAT; C-REACTIVE PROTEIN; ENDOTHELIAL DYSFUNCTION;
   NITRIC-OXIDE; VASCULAR FUNCTION; PERICARDIAL FAT; OXIDATIVE STRESS;
   PERIADVENTITIAL FAT; METABOLIC SYNDROME; GENE-EXPRESSION
AB Adipose tissue is an active endocrine and paracrine organ that may influence the development of atherosclerosis and vascular disease. In the setting of obesity, adipose tissue produces a variety of inflammatory cytokines (or adipokines) that are known to modulate key mechanisms of atherogenesis. In particular, adipose tissue located on the surface of the heart surrounding large coronary arteries (i.e. epicardial perivascular adipose tissue) has been implicated in the pathogenesis of coronary artery disease. The present review outlines our current understanding of the cellular and molecular links between perivascular adipose tissue and atherosclerosis with a focus on potential mechanisms by which epicardial perivascular adipose tissue contributes to obesity-related coronary disease. The pathophysiology of perivascular adipose tissue in obesity and its influence on oxidative stress, inflammation, endothelial dysfunction and vascular reactivity is addressed. In addition, the contribution of specific epicardial perivascular adipose-derived adipokines (e.g. leptin, adiponectin) to the initiation and expansion of coronary disease is also highlighted. Finally, future investigative goals are discussed with an emphasis on indentifying novel therapeutic targets and disease markers within perivascular adipose tissue.
C1 [Payne, Gregory A.; Kohr, Meredith C.; Tune, Johnathan D.] Indiana Univ, Sch Med, Dept Cellular & Integrat Physiol, Indianapolis, IN 46202 USA.
C3 Indiana University System; Indiana University Indianapolis
RP Tune, JD (corresponding author), Indiana Univ, Sch Med, Dept Cellular & Integrat Physiol, 635 Barnhill Dr, Indianapolis, IN 46202 USA.
EM jtune@iupui.edu
OI Payne, Gregory/0000-0002-8525-8603; Tune, Johnathan/0000-0003-2959-0801
FU NIH [R01 HL092245, F31 HL095362]
FX This work was supported by NIH grants R01 HL092245 ( JDT) and F31
   HL095362 (GAP).
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NR 115
TC 93
Z9 103
U1 0
U2 18
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0007-1188
EI 1476-5381
J9 BRIT J PHARMACOL
JI Br. J. Pharmacol.
PD FEB
PY 2012
VL 165
IS 3
SI SI
BP 659
EP 669
DI 10.1111/j.1476-5381.2011.01370.x
PG 11
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 874JS
UT WOS:000298953100010
PM 21545577
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Ye, J
AF Ye, J.
TI Emerging role of adipose tissue hypoxia in obesity and insulin
   resistance
SO INTERNATIONAL JOURNAL OF OBESITY
LA English
DT Review
DE adipose tissue; insulin resistance; hypoxia; inflammation; angiogenesis
ID NF-KAPPA-B; INDUCIBLE FACTOR-I; MIGRATION INHIBITORY FACTOR;
   NECROSIS-FACTOR-ALPHA; ENDOTHELIAL GROWTH-FACTOR; ENDOPLASMIC-RETICULUM
   STRESS; ADIPONECTIN GENE-EXPRESSION; ACTIVATED PROTEIN-KINASE;
   RENIN-ANGIOTENSIN SYSTEM; MULTIPLE SERINE KINASES
AB Recent studies consistently support a hypoxia response in the adipose tissue in obese animals. The observations have led to the formation of an exciting concept, adipose tissue hypoxia (ATH), in the understanding of major disorders associated with obesity. ATH may provide cellular mechanisms for chronic inflammation, macrophage infiltration, adiponectin reduction, leptin elevation, adipocyte death, endoplasmic reticulum stress and mitochondrial dysfunction in white adipose tissue in obesity. The concept suggests that inhibition of adipogenesis and triglyceride synthesis by hypoxia may be a new mechanism for elevated free fatty acids in the circulation in obesity. ATH may represent a unified cellular mechanism for a variety of metabolic disorders and insulin resistance in patients with metabolic syndrome. It suggests a new mechanism of pathogenesis of insulin resistance and inflammation in obstructive sleep apnea. In addition, it may help us to understand the beneficial effects of caloric restriction, physical exercise and angiotensin II inhibitors in the improvement of insulin sensitivity. In this review article, literatures are reviewed to summarize the evidence and possible cellular mechanisms of ATH. The directions and road blocks in the future studies are analyzed.
C1 Louisiana State Univ Syst, Pennington Biomed Res Ctr, Gene Regulat Lab, Baton Rouge, LA 70808 USA.
C3 Louisiana State University System; Louisiana State University;
   Pennington Biomedical Research Center
RP Ye, J (corresponding author), Louisiana State Univ Syst, Pennington Biomed Res Ctr, Gene Regulat Lab, 6400 Perkins Rd,Room L1019, Baton Rouge, LA 70808 USA.
EM jianping.ye@pbrc.edu
RI Ye, Jianping/N-1998-2017
OI Ye, Jianping/0000-0003-3875-365X
FU NIH [DK68036]; ADA [7-07-RA-189]
FX This paper was prepared with support by NIH fund (DK68036) and ADA
   research award (7-07-RA-189) to J Ye.
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NR 209
TC 391
Z9 459
U1 1
U2 48
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0307-0565
EI 1476-5497
J9 INT J OBESITY
JI Int. J. Obes.
PD JAN
PY 2009
VL 33
IS 1
BP 54
EP 66
DI 10.1038/ijo.2008.229
PG 13
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 393ML
UT WOS:000262377300010
PM 19050672
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Mirmiran, P
   Amirhamidi, Z
   Ejtahed, HS
   Bahadoran, Z
   Azizi, F
AF Mirmiran, Parvin
   Amirhamidi, Zeynab
   Ejtahed, Hanieh-Sadat
   Bahadoran, Zahra
   Azizi, Fereidoun
TI Relationship between Diet and Non-alcoholic Fatty Liver Disease: A
   Review Article
SO IRANIAN JOURNAL OF PUBLIC HEALTH
LA English
DT Review
DE Non-alcoholic fatty liver disease; Food groups; Dietary patterns
ID ENDOPLASMIC-RETICULUM STRESS; MEDITERRANEAN DIET; INSULIN-RESISTANCE;
   METABOLIC SYNDROME; HEPATIC STEATOSIS; OXIDATIVE STRESS; OBESITY;
   CARBOHYDRATE; RISK; INFLAMMATION
AB Background: Diet plays a key role in the development of non-alcoholic fatty liver disease (NAFLD). The aim of this study was to review systematically observational studies available regarding the relationship between food intakes and NAFLD.
   Methods: We searched Scopus, PubMed, and Cochrane Library databases to identify English observational studies on food groups, dietary patterns, and NAFLD. Cross-sectional, case-control and cohort studies were selected and then duplication, topic, type of study, study population, variables examined and quality of data reporting of the articles were evaluated.
   Results: We identified 2128 studies in the initial search, of which 33 were reviewed in full text and 7 articles were included in this systematic review. Intakes of red meat, fats, and sweets were high whereas consumption of whole grains, fruits and vegetables were less in NAFLD patients. Moreover, there was a positive association between the Western dietary pattern and the risk of NAFLD, while adherence to the Mediterranean diet was significantly associated with the severity of hepatic steatosis.
   Conclusion: Generally, different food group intakes and dietary patterns are associated with the progression of NAFLD and its risk factors. Because of the many limitations of available studies reviewed on this topic, more prospective studies are suggested.
C1 [Mirmiran, Parvin; Amirhamidi, Zeynab; Ejtahed, Hanieh-Sadat; Bahadoran, Zahra] Shahid Beheshti Univ Med Sci, Res Inst Endocrine Sci, Nutr & Endocrine Res Ctr, Tehran, Iran.
   [Azizi, Fereidoun] Shahid Beheshti Univ Med Sci, Res Inst Endocrine Sci, Endocrine Res Ctr, Tehran, Iran.
C3 Shahid Beheshti University Medical Sciences; Shahid Beheshti University
   Medical Sciences
RP Bahadoran, Z (corresponding author), Shahid Beheshti Univ Med Sci, Res Inst Endocrine Sci, Nutr & Endocrine Res Ctr, Tehran, Iran.
EM z.bahadoran@endocrine.ac.ir
RI ejtahed, hanieh/AAH-4921-2021; Bahadoran, Zahra/V-2003-2019; Mirmiran,
   Parvin/V-1433-2019; Azizi, Fereidoun/ABD-4136-2021
OI Azizi, Fereidoun/0000-0002-6470-2517; Ejtahed,
   Hanieh-Sadat/0000-0002-6395-4915; Mirmiran, Parvin/0000-0003-2391-4924
FU Research Institute of Endocrine Sciences, Shahid Beheshti University of
   Medical Sciences, Tehran, Iran
FX This study was funded by the Research Institute of Endocrine Sciences,
   Shahid Beheshti University of Medical Sciences, Tehran, Iran. The
   authors express to acknowledge the assistance given by Ms. Niloofar
   Shiva for critical editing of English grammar and syntax.
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NR 57
TC 72
Z9 74
U1 0
U2 19
PU IRANIAN SCIENTIFIC SOCIETY MEDICAL ENTOMOLOGY
PI TEHRAN
PA SCHOOL PUBLIC HEALTH & INST HEALTH RESEARCH, TEHRAN UNIV MEDICAL
   SCIENCES, P O BOX  6446-14155, TEHRAN, 00000, IRAN
SN 2251-6085
EI 2251-6093
J9 IRAN J PUBLIC HEALTH
JI Iran J. Public Health
PD AUG
PY 2017
VL 46
IS 8
BP 1007
EP 1017
PG 11
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA FB7FN
UT WOS:000406306600001
PM 28894701
DA 2025-06-11
ER

PT J
AU Ohno, K
   Ito, M
   Ichihara, M
   Ito, M
AF Ohno, Kinji
   Ito, Mikako
   Ichihara, Masatoshi
   Ito, Masafumi
TI Molecular Hydrogen as an Emerging Therapeutic Medical Gas for
   Neurodegenerative and Other Diseases
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Review
ID RICH SALINE PROTECTS; ELECTROLYZED REDUCED WATER; CISPLATIN-INDUCED
   NEPHROTOXICITY; OXIDATIVE STRESS; ISCHEMIA/REPERFUSION INJURY;
   ISCHEMIA-REPERFUSION; RAT MODEL; LUNG INJURY; INTESTINAL
   ISCHEMIA/REPERFUSION; CEREBRAL-ISCHEMIA
AB Effects of molecular hydrogen on various diseases have been documented for 63 disease models and human diseases in the past four and a half years. Most studies have been performed on rodents including two models of Parkinson's disease and three models of Alzheimer's disease. Prominent effects are observed especially in oxidative stress-mediated diseases including neonatal cerebral hypoxia; Parkinson's disease; ischemia/reperfusion of spinal cord, heart, lung, liver, kidney, and intestine; transplantation of lung, heart, kidney, and intestine. Six human diseases have been studied to date: diabetes mellitus type 2, metabolic syndrome, hemodialysis, inflammatory and mitochondrial myopathies, brain stem infarction, and radiation-induced adverse effects. Two enigmas, however, remain to be solved. First, no dose-response effect is observed. Rodents and humans are able to take a small amount of hydrogen by drinking hydrogen-rich water, but marked effects are observed. Second, intestinal bacteria in humans and rodents produce a large amount of hydrogen, but an addition of a small amount of hydrogen exhibits marked effects. Further studies are required to elucidate molecular bases of prominent hydrogen effects and to determine the optimal frequency, amount, and method of hydrogen administration for each human disease.
C1 [Ohno, Kinji; Ito, Mikako] Nagoya Univ, Grad Sch Med, Ctr Neurol Dis & Canc, Div Neurogenet,Showa Ku, Nagoya, Aichi 4668550, Japan.
   [Ichihara, Masatoshi] Chubu Univ, Dept Biomed Sci, Coll Life & Hlth Sci, Aichi 4878501, Japan.
   [Ito, Masafumi] Tokyo Metropolitan Inst Gerontol, Res Team Mech Aging, Tokyo 1730015, Japan.
C3 Nagoya University; Chubu University; Tokyo Metropolitan Institute of
   Gerontology
RP Ohno, K (corresponding author), Nagoya Univ, Grad Sch Med, Ctr Neurol Dis & Canc, Div Neurogenet,Showa Ku, 65 Tsurumai, Nagoya, Aichi 4668550, Japan.
EM ohnok@med.nagoya-u.ac.jp
RI Ohno, Kinji/ABD-5787-2020; Ito, Mikako/I-1941-2012; Ohno,
   Kinji/H-4020-2012
OI Ohno, Kinji/0000-0002-1529-2750
FU MEXT of Japan; MHLW of Japan; Priority Research Project of Aichi;
   Grants-in-Aid for Scientific Research [22300244, 24590768] Funding
   Source: KAKEN
FX Works performed in the authors' laboratories were supported by
   Grants-in-Aid from the MEXT and MHLW of Japan and from the Priority
   Research Project of Aichi.
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NR 105
TC 134
Z9 146
U1 5
U2 56
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PY 2012
VL 2012
AR 353152
DI 10.1155/2012/353152
PG 11
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA 968WZ
UT WOS:000306017500001
PM 22720117
OA Green Published, Green Submitted, hybrid
DA 2025-06-11
ER

PT J
AU Roussel, AM
   Hininger, I
   Benaraba, R
   Ziegenfuss, TN
   Anderson, RA
AF Roussel, Anne-Marie
   Hininger, Isabelle
   Benaraba, Rachida
   Ziegenfuss, Tim N.
   Anderson, Richard A.
TI Antioxidant Effects of a Cinnamon Extract in People with Impaired
   Fasting Glucose That Are Overweight or Obese
SO JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION
LA English
DT Article; Proceedings Paper
CT 47th Annual Meeting of the American-College-of-Nutrition
CY OCT 05-08, 2006
CL Reno, NV
SP Amer Coll Nutr
DE cinnamon; antioxidants; glucose; diabetes; insulin
ID OXIDATIVE STRESS; DIABETES-MELLITUS; INSULIN-RESISTANCE; METABOLIC
   SYNDROME; OXIDANT STRESS; POLYPHENOLS; MECHANISMS; PLASMA;
   HYPERGLYCEMIA; LIPIDS
AB Objective: To determine the effects of a dried aqueous extract of cinnamon on antioxidant status of people with impaired fasting glucose that are overweight or obese.
   Methods: Twenty-two subjects, with impaired fasting blood glucose with BMI ranging from 25 to 45, were enrolled in a double-blind placebo-controlled trial. Subjects were given capsules containing either a placebo or 250 mg of an aqueous extract of cinnamon (Cinnulin PF) two times per day for 12 weeks. Plasma malondialdehyde (NIDA) concentrations were assessed using high performance liquid chromatography and plasma antioxidant status was evaluated using ferric reducing antioxidant power (FRAP) assay. Erythrocyte Cu-Zn superoxide (Cu-Zn SOD) activity was measured after hemoglobin precipitation by monitoring the auto-oxidation of pyrogallol and erythrocyte glutathione peroxidase (GPx) activity by established methods.
   Results: FRAP and plasma thiol (SH) groups increased, while plasma MDA levels decreased in subjects receiving the cinnamon extract. Effects were larger after 12 than 6 weeks. There was also a positive correlation (r = 0.74; p = 0.014) between MDA and plasma glucose.
   Conclusion: This study supports the hypothesis that the inclusion of water soluble cinnamon compounds in the diet could reduce risk factors associated with diabetes and cardiovascular disease.
C1 [Anderson, Richard A.] ARS, USDA, BHNRC, DGIL, Beltsville, MD 20705 USA.
   [Roussel, Anne-Marie; Hininger, Isabelle; Benaraba, Rachida] Univ Grenoble 1, INSERM, U884, Grenoble, France.
   [Roussel, Anne-Marie; Hininger, Isabelle; Benaraba, Rachida] Univ Grenoble 1, LBFA, Grenoble, France.
   [Ziegenfuss, Tim N.] Ohio Res Grp, Wadsworth, OH USA.
C3 United States Department of Agriculture (USDA); Institut National de la
   Sante et de la Recherche Medicale (Inserm); Communaute Universite
   Grenoble Alpes; Universite Grenoble Alpes (UGA); Communaute Universite
   Grenoble Alpes; Universite Grenoble Alpes (UGA)
RP Anderson, RA (corresponding author), ARS, USDA, BHNRC, DGIL, Bldg 307C,Rm 222, Beltsville, MD 20705 USA.
EM Richard.Anderson@ars.usda.gov
OI hininger-favier, isabelle/0000-0001-6726-7533
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NR 39
TC 127
Z9 145
U1 1
U2 23
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 0731-5724
EI 1541-1087
J9 J AM COLL NUTR
JI J. Am. Coll. Nutr.
PD FEB
PY 2009
VL 28
IS 1
BP 16
EP 21
DI 10.1080/07315724.2009.10719756
PG 6
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Nutrition & Dietetics
GA 471FJ
UT WOS:000268041000003
PM 19571155
DA 2025-06-11
ER

PT J
AU Cong, WN
   Wang, R
   Cai, H
   Daimon, CM
   Scheibye-Knudsen, M
   Bohr, VA
   Turkin, R
   Wood, WH
   Becker, KG
   Moaddel, R
   Maudsley, S
   Martin, B
AF Cong, Wei-na
   Wang, Rui
   Cai, Huan
   Daimon, Caitlin M.
   Scheibye-Knudsen, Morten
   Bohr, Vilhelm A.
   Turkin, Rebecca
   Wood, William H., III
   Becker, Kevin G.
   Moaddel, Ruin
   Maudsley, Stuart
   Martin, Bronwen
TI Long-Term Artificial Sweetener Acesulfame Potassium Treatment Alters
   Neurometabolic Functions in C57BL/6J Mice
SO PLOS ONE
LA English
DT Article
ID BODY-SURFACE AREA; SYNAPTIC PLASTICITY; ALZHEIMERS-DISEASE; METABOLIC
   SYNDROME; CREATINE-KINASE; MAMMALIAN SWEET; SH-SY5Y CELLS;
   UP-REGULATION; P-ERK; TASTE
AB With the prevalence of obesity, artificial, non-nutritive sweeteners have been widely used as dietary supplements that provide sweet taste without excessive caloric load. In order to better understand the overall actions of artificial sweeteners, especially when they are chronically used, we investigated the peripheral and central nervous system effects of protracted exposure to a widely used artificial sweetener, acesulfame K (ACK). We found that extended ACK exposure (40 weeks) in normal C57BL/6J mice demonstrated a moderate and limited influence on metabolic homeostasis, including altering fasting insulin and leptin levels, pancreatic islet size and lipid levels, without affecting insulin sensitivity and bodyweight. Interestingly, impaired cognitive memory functions (evaluated by Morris Water Maze and Novel Objective Preference tests) were found in ACK-treated C57BL/6J mice, while no differences in motor function and anxiety levels were detected. The generation of an ACK-induced neurological phenotype was associated with metabolic dysregulation (glycolysis inhibition and functional ATP depletion) and neurosynaptic abnormalities (dysregulation of TrkB-mediated BDNF and Akt/Erk-mediated cell growth/survival pathway) in hippocampal neurons. Our data suggest that chronic use of ACK could affect cognitive functions, potentially via altering neuro-metabolic functions in male C57BL/6J mice.
C1 [Cong, Wei-na; Wang, Rui; Cai, Huan; Daimon, Caitlin M.; Turkin, Rebecca; Martin, Bronwen] NIA, Metab Unit, Clin Invest Lab, Baltimore, MD 21224 USA.
   [Scheibye-Knudsen, Morten; Bohr, Vilhelm A.] NIA, Sect DNA Repair, Lab Mol Gerontol, Baltimore, MD 21224 USA.
   [Wood, William H., III; Becker, Kevin G.] NIA, Gene Express & Genom Unit, Genet Lab, Baltimore, MD 21224 USA.
   [Maudsley, Stuart] NIA, Receptor Pharmacol Unit, Neurosci Lab, Baltimore, MD 21224 USA.
   [Moaddel, Ruin] NIA, Bioanalyt Chem & Drug Discovery Sect, Clin Invest Lab, Baltimore, MD 21224 USA.
C3 National Institutes of Health (NIH) - USA; NIH National Institute on
   Aging (NIA); National Institutes of Health (NIH) - USA; NIH National
   Institute on Aging (NIA); National Institutes of Health (NIH) - USA; NIH
   National Institute on Aging (NIA); National Institutes of Health (NIH) -
   USA; NIH National Institute on Aging (NIA); National Institutes of
   Health (NIH) - USA; NIH National Institute on Aging (NIA)
RP Martin, B (corresponding author), NIA, Metab Unit, Clin Invest Lab, Baltimore, MD 21224 USA.
EM martinbro@mail.nih.gov
RI Bohr, Vilhelm/AAP-5931-2020; Maudsley, Stuart/Q-4782-2019; Moaddel,
   Ruin/AAE-3378-2020; Wang, Rui/I-5643-2019; Cai, Huan/B-6578-2016;
   Maudsley, Stuart/O-7565-2015
OI Moaddel, Ruin/0000-0002-6812-0127; Cai, Huan/0000-0001-7731-8891;
   Becker, Kevin/0000-0002-6794-6656; Martin, Bronwen/0000-0002-9185-6925;
   Wang, Rui/0000-0001-7015-0272; Scheibye-Knudsen,
   Morten/0000-0002-6637-1280; Maudsley, Stuart/0000-0002-1868-184X
FU Intramural Research Program of the National Institute on Aging at the
   National Institutes of Health
FX This work was carried out with the support of the Intramural Research
   Program of the National Institute on Aging at the National Institutes of
   Health. The funders had no role in study design, data collection and
   analysis, decision to publish, or preparation of the manuscript.
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NR 89
TC 49
Z9 52
U1 3
U2 74
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD AUG 7
PY 2013
VL 8
IS 8
AR e70257
DI 10.1371/journal.pone.0070257
PG 18
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 200ZE
UT WOS:000323109700025
PM 23950916
OA gold, Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Yadav, RK
   Magan, D
   Mehta, N
   Sharma, R
   Mahapatra, SC
AF Yadav, Raj Kumar
   Magan, Dipti
   Mehta, Nalin
   Sharma, Ratna
   Mahapatra, Sushil Chandra
TI Efficacy of a Short-Term Yoga-Based Lifestyle Intervention in Reducing
   Stress and Inflammation: Preliminary Results
SO JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE
LA English
DT Article
ID SELF-MANAGEMENT PROGRAM; PROSTATE-CANCER OUTPATIENTS; RANDOMIZED
   CONTROLLED-TRIAL; TUMOR-NECROSIS-FACTOR; BETA-ENDORPHIN; METABOLIC
   SYNDROME; TNF-ALPHA; GLUCOSE-METABOLISM; INSULIN-RESISTANCE; CHRONIC
   DISEASE
AB Objectives: Previously it was shown that a brief yoga-based lifestyle intervention was efficacious in reducing oxidative stress and risk of chronic diseases even in a short duration. The objective of this study was to assess the efficacy of this intervention in reducing stress and inflammation in patients with chronic inflammatory diseases.
   Design: This study reports preliminary results from a nonrandomized prospective ongoing study with pre-post design.
   Setting/location: The study was conducted at the Integral Health Clinic, an outpatient facility conducting these yoga-based lifestyle intervention programs for prevention and management of chronic diseases.
   Subjects: Patients with chronic inflammatory diseases and overweight/obese subjects were included while physically challenged, and those on other interventions were excluded from the study.
   Intervention: A pretested intervention program included asanas (postures), pranayama (breathing exercises), stress management, group discussions, lectures, and individualized advice.
   Outcome measures: There was a reduction in stress (plasma cortisol and beta-endorphin) and inflammation (interleukin [IL]-6 and tumor necrosis factor [TNF]-alpha) at day 0 versus day 10.
   Results: Eighty-six (86) patients (44 female, 42 male, 40.07 +/- 13.91 years) attended this program. Overall, the mean level of cortisol decreased from baseline to day 10 (149.95 +/- 46.07, 129.07 +/- 33.30 ng/mL; p = 0.001) while beta-endorphins increased from baseline to day 10 (3.53 +/- 0.88, 4.06 +/- 0.79 ng/mL; p = 0.024). Also, there was reduction from baseline to day 10 in mean levels of IL-6 (2.16 +/- 0.42, 1.94 +/- 0.10 pg/mL, p = 0.036) and TNF-alpha (2.85 +/- 0.59, 1.95 +/- 0.32 pg/mL, p = 0.002).
   Conclusions: This brief yoga-based lifestyle intervention reduced the markers of stress and inflammation as early as 10 days in patients with chronic diseases; however, complete results of this study will confirm whether this program has utility as complementary and alternative therapy.
C1 [Yadav, Raj Kumar; Magan, Dipti; Mehta, Nalin; Sharma, Ratna; Mahapatra, Sushil Chandra] All India Inst Med Sci, Dept Physiol, Integral Hlth Clin, New Delhi 110029, India.
C3 All India Institute of Medical Sciences (AIIMS) New Delhi
RP Yadav, RK (corresponding author), All India Inst Med Sci, Dept Physiol, Integral Hlth Clin, New Delhi 110029, India.
EM raj3kr@gmail.com
RI Yadav, Raj Kumar/AFT-0686-2022
OI Yadav, Raj Kumar/0000-0002-5066-7028; Mahapatra, Sushil
   Chandra/0000-0001-6983-7528; Sharma, Ratna/0000-0001-6810-3514
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NR 58
TC 117
Z9 134
U1 0
U2 55
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1075-5535
EI 1557-7708
J9 J ALTERN COMPLEM MED
JI J. Altern. Complement Med.
PD JUL
PY 2012
VL 18
IS 7
BP 662
EP 667
DI 10.1089/acm.2011.0265
PG 6
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Integrative & Complementary Medicine
GA 979JE
UT WOS:000306812500006
PM 22830969
DA 2025-06-11
ER

PT J
AU Xiao, X
   Wu, FH
   Wang, B
   Cai, ZP
   Wang, LY
   Zhang, YF
   Yu, XD
   Luo, YP
AF Xiao, Xian
   Wu, Fanhua
   Wang, Bing
   Cai, Zeping
   Wang, Lanying
   Zhang, Yunfei
   Yu, Xudong
   Luo, Yanping
TI Clerodendranthus spicatus (Thunb.) Water Extracts Reduce Lipid
   Accumulation and Oxidative Stress in the Caenorhabditis elegans
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE Caenorhabditis elegans; Clerodendranthus spicatus; kidney tea;
   anti-ageing; antioxidant; resistance
ID ORTHOSIPHON-STAMINEUS BENTH.; METABOLIC SYNDROME; INHIBITION; RISK
AB Clerodendranthus spicatus (Thunb.) (Kidney tea) is a very distinctive ethnic herbal medicine in China. Its leaves are widely used as a healthy tea. Many previous studies have demonstrated its various longevity-promoting effects; however, the safety and specific health-promoting effects of Clerodendranthus spicatus (C. spicatus) as a dietary supplement remain unclear. In order to understand the effect of C. spicatus on the longevity of Caenorhabditis elegans (C. elegans), we evaluated its role in C. elegans; C. spicatus water extracts (CSw) were analyzed for the major components and the effects on C. elegans were investigated from physiological and biochemical to molecular levels; CSw contain significant phenolic components (primarily rosmarinic acid and eugenolinic acid) and flavonoids (primarily quercetin and isorhamnetin) and can increase the lifespan of C. elegans. Further investigations showed that CSw modulate stress resistance and lipid metabolism through influencing DAF-16/FoxO (DAF-16), Heat shock factor 1 (HSF-1), and Nuclear Hormone Receptor-49 (NHR-49) signalling pathways; CSw can improve the antioxidant and hypolipidemic activity of C. elegans and prolong the lifespan of C. elegans (with the best effect at low concentrations). Therefore, the recommended daily use of C. spicatus should be considered when consuming it as a healthy tea on a daily basis.
C1 [Xiao, Xian; Wang, Bing; Cai, Zeping; Wang, Lanying; Zhang, Yunfei; Yu, Xudong; Luo, Yanping] Hainan Univ, Sch Trop Agr & Forestry, Haikou 570228, Peoples R China.
   [Wu, Fanhua] Hainan Univ, Sch Life Sci, Haikou 570228, Peoples R China.
C3 Hainan University; Hainan University
RP Yu, XD; Luo, YP (corresponding author), Hainan Univ, Sch Trop Agr & Forestry, Haikou 570228, Peoples R China.
EM ynxiaoxian@163.com; wrwfh@163.com; wang0307bing@163.com;
   992995@hainanu.edu.cn; daivemuwly@126.com; diyfzhang@163.com;
   yuxd@hainanu.edu.cn; yanpluo2012@hainanu.edu.cn
RI wang, bing/MZQ-4419-2025
OI Cai, Zeping/0000-0002-2097-0077; , yanping luo/0000-0002-2184-4291
FU Natural Science Foundation of Hainan Province; Natural Science
   Foundation of Hainan Province, China [321MS010]; Hainan Province Science
   and Technology Species Fund [ZDKJ2021041];  [324RC454]
FX This study was supported by the Natural Science Foundation of Hainan
   Province, China (321MS010), Hainan Province Science and Technology
   Species Fund (ZDKJ2021041) and the Natural Science Foundation of Hainan
   Province (324RC454).
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NR 48
TC 3
Z9 3
U1 14
U2 30
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD SEP
PY 2024
VL 25
IS 17
AR 9655
DI 10.3390/ijms25179655
PG 17
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA F7R5N
UT WOS:001311747300001
PM 39273603
OA gold
DA 2025-06-11
ER

PT J
AU Wang, KP
   Cao, P
   Wang, HX
   Tang, ZH
   Wang, N
   Wang, JL
   Zhang, Y
AF Wang, Kaiping
   Cao, Peng
   Wang, Hanxiang
   Tang, Zhuohong
   Wang, Na
   Wang, Jinglin
   Zhang, Yu
TI Chronic administration of Angelica sinensis polysaccharide
   effectively improves fatty liver and glucose homeostasis in high-fat
   diet-fed mice
SO SCIENTIFIC REPORTS
LA English
DT Article
ID INSULIN-RESISTANCE; OXIDATIVE STRESS; INDUCED OBESITY; METABOLISM;
   INHIBITION; C57BL/6J; RATS; STEATOHEPATITIS; ADIPONECTIN; STEATOSIS
AB This study aimed to investigate the therapeutic effects of Angelica sinensis polysaccharide (ASP), an active component derived from a water extract of Angelica sinensis, in high-fat diet (HFD)-fed BALB/c mice. The potential mechanisms underlying the activity of this compound were also considered. Specifically, serum and hepatic biochemical parameters were evaluated, and key proteins involved in the lipid/glucose metabolism were analyzed. Long-term feeding with a HFD induced severe fatty liver and hyperglycemia. Histological examination clearly showed that ASP reduced lipid accumulation in the liver and attenuated hepatic steatosis in HFD-fed mice. In addition, ASP markedly alleviated serum and liver lipid disorders and fatty liver via the upregulation of PPAR gamma expression and the activation of adiponectin-SIRT1-AMPK signaling. Furthermore, ASP also significantly relieved severe oxidative stress, demonstrating that ASP might attenuate nonalcoholic fatty liver disease via a "two-hit" mechanism. In addition, ASP reduced blood glucose levels and ameliorated insulin resistance via the regulation of related metabolic enzymes and by activating the PI3K/Akt pathway in HFD-fed mice. Our findings revealed that ASP might be used as an alternative dietary supplement or health care product to ameliorate metabolic syndrome in populations that consistently consume HFDs.
C1 [Wang, Kaiping; Cao, Peng; Wang, Hanxiang; Tang, Zhuohong] Huazhong Univ Sci & Technol, Tongji Med Coll, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Peoples R China.
   [Wang, Na] Wuhan Univ, Renmin Hosp, Dept Pharm, 99 Zhangzhidong Rd, Wuhan 430060, Peoples R China.
   [Wang, Jinglin; Zhang, Yu] Huazhong Univ Sci & Technol, Dept Pharm, Union Hosp, 1227 Jiefang Rd, Wuhan 430030, Peoples R China.
C3 Huazhong University of Science & Technology; Wuhan University; Huazhong
   University of Science & Technology
RP Zhang, Y (corresponding author), Huazhong Univ Sci & Technol, Dept Pharm, Union Hosp, 1227 Jiefang Rd, Wuhan 430030, Peoples R China.
EM zhangwkp@163.com
RI YUXIN, ZHANG/GNH-2283-2022
OI Wang, Kai-Ping/0000-0001-6572-3435; Cao, Peng/0000-0001-7228-3511
FU National Natural Science Foundation of China [81274151, 81403205]
FX We appreciate the staff from the Analysis and Testing Center of Huazhong
   University of Science and Technology for their technical assistance. The
   present research was supported by grants from the National Natural
   Science Foundation of China (Grant No. 81274151 and 81403205).
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U1 3
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PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD MAY 18
PY 2016
VL 6
AR 26229
DI 10.1038/srep26229
PG 11
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA DL9WW
UT WOS:000375995100001
PM 27189109
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Mock, ED
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AF Mock, Elliot D.
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   van der Stelt, Mario
TI Anandamide and other N-acylethanolamines: A class of signaling lipids
   with therapeutic opportunities
SO PROGRESS IN LIPID RESEARCH
LA English
DT Review
ID FATTY-ACID-AMIDE; ENDOGENOUS CANNABINOID SYSTEM; SOLUBLE EPOXIDE
   HYDROLASE; SUBCUTANEOUS ADIPOSE-TISSUE; SELECTIVE COX-2 INHIBITION;
   PHOSPHOLIPASE-D; ENDOCANNABINOID SYSTEM; MOLECULAR CHARACTERIZATION; CB1
   RECEPTOR; FOOD-INTAKE
AB N-acylethanolamines (NAEs), including N-palmitoylethanolamine (PEA), N-oleoylethanolamine (OEA), N-arachidonoylethanolamine (AEA, anandamide), N-doco-sahexaenoylethanolamine (DHEA, synaptamide) and their oxygenated metabolites are a lipid messenger family with numerous functions in health and disease, including inflammation, anxiety and energy metabolism. The NAEs exert their signaling role through activation of various G protein-coupled receptors (cannabinoid CB1 and CB2 receptors, GPR55, GPR110, GPR119), ion channels (TRPV1) and nuclear receptors (PPAR-alpha and PPAR-gamma) in the brain and periphery. The biological role of the oxygenated NAEs, such as prostamides, hydroxylated anandamide and DHEA derivatives, are less studied. Evidence is accumulating that NAEs and their oxidative metabolites may be aberrantly regulated or are associated with disease severity in obesity, metabolic syndrome, cancer, neuroinflammation and liver cirrhosis. Here, we comprehensively review NAE biosynthesis and degradation, their metabolism by lipoxygenases, cyclooxygenases and cytochrome P450s and the biological functions of these signaling lipids. We discuss the latest findings and therapeutic potential of modulating endogenous NAE levels by inhibition of their degradation, which is currently under clinical evaluation for neuropsychiatric disorders. We also highlight NAE biosynthesis inhibition as an emerging topic with therapeutic opportunities in endocannabinoid and NAE signaling.
C1 [van der Stelt, Mario] Leiden Univ, Leiden Inst Chem, Dept Mol Physiol, Einsteinweg 55, NL-2333 CC Leiden, Netherlands.
   [van der Stelt, Mario] Oncode Inst, Einsteinweg 55, NL-2333 CC Leiden, Netherlands.
   [Mock, Elliot D.] Univ Oxford, Dept Physiol Anat & Genet, Sherrington Rd, Oxford OX1 3QU, England.
C3 Leiden University; Leiden University - Excl LUMC; University of Oxford
RP van der Stelt, M (corresponding author), Leiden Univ, Leiden Inst Chem, Dept Mol Physiol, Einsteinweg 55, NL-2333 CC Leiden, Netherlands.; van der Stelt, M (corresponding author), Oncode Inst, Einsteinweg 55, NL-2333 CC Leiden, Netherlands.
EM m.van.der.stelt@chem.leidenuniv.nl
RI Mock, Elliot/HGU-3426-2022
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NR 430
TC 69
Z9 75
U1 10
U2 54
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0163-7827
EI 1873-2194
J9 PROG LIPID RES
JI Prog. Lipid Res.
PD JAN
PY 2023
VL 89
AR 101194
DI 10.1016/j.plipres.2022.101194
EA JAN 2023
PG 24
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA 9Z3CH
UT WOS:000951021200001
PM 36150527
OA hybrid, Green Published
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Francomano, D
   Aversa, A
AF Francomano, Davide
   Aversa, Antonio
TI ACUTE EFFECT OF POLYPHENOLS AND MYO-INOSITOL ON ENDOTHELIAL FUNCTION: A
   PILOT STUDY
SO CURRENT TOPICS IN NUTRACEUTICAL RESEARCH
LA English
DT Article
DE Atherosclerosis; Cardiovascular risk; Endothelial dysfunction;
   Prevention.
ID FLAVANOL-RICH COCOA; NITRIC-OXIDE; RISK-FACTORS; VASCULAR FUNCTION;
   DYSFUNCTION; ATHEROSCLEROSIS; ACTIVATION; DISEASE; SMOKERS; ADULTS
AB Oxidative stress is involved in the pathogenesis of cardiovascular (CV) risk and endothelial dysfunction represents the predictor of atherosclerosis starting early in the life. The assessment of endothelial function is able to detect cardiovascular disease in asymptomatic patients. Polyphenol-rich nutrients are known to reduce oxidative stress and increasing nitric oxide generation. The effect of a cocoa derived polyphenols+myo-inositol on endothelial function has never been investigated. We studied in a series of volunteers (20 healthy subjects-CTR and 10 subjects affected by metabolic syndrome-MS) the acute vascular effects of a single assumption of a fix dose of polyphenols and myo-inositol by using Endopat2000. The administration induced a significant improvement of endothelial function in the MS population (+37% vs. baseline, p<0.01); also, when a subgroup of CTR according to the presence of endothelial dysfunction (LnRHI <0.51 - n=10 subject) or normal endothelial function (LnRHI >0.51 - n=10 subject)] was investigated we found a significant improvement in subjects affected by endothelial dysfunction only (+ 69%, p< 0.01). These preliminary results suggest that acute assumption of cocoa-derived polyphenols+myo-inositol is able to improve vascular reactivity in MS and also in young subjects affected by endothelial dysfunction.
C1 [Francomano, Davide] Sapienza Univ Rome, Dept Expt Med Med Pathophysiol Food & Sci, Viale Regina Elena 324, I-00161 Rome, Italy.
   [Francomano, Davide] Sapienza Univ Rome, Endocrinol Sect, Viale Regina Elena 324, I-00161 Rome, Italy.
   [Francomano, Davide; Aversa, Antonio] Magna Graecia Univ Catanzaro, Dept Clin & Expt Med, Catanzaro, Italy.
C3 Sapienza University Rome; Sapienza University Rome; Magna Graecia
   University of Catanzaro
RP Francomano, D (corresponding author), Viale Regina Elena 324, I-00161 Rome, Italy.
EM davide.francomano@uniroma1.it
RI Aversa, Antonio/O-3151-2019
CR Anderson TJ, 2015, PROG CARDIOVASC DIS, V57, P497, DOI 10.1016/j.pcad.2014.11.005
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NR 27
TC 0
Z9 0
U1 0
U2 1
PU NEW CENTURY HEALTH PUBLISHERS, LLC
PI COPPELL
PA PO BOX 175, COPPELL, TX 75019 USA
SN 1540-7535
J9 CURR TOP NUTRACEUT R
JI Curr. Top. Nutraceutical Res.
PD AUG
PY 2016
VL 14
IS 3
BP 235
EP 240
PG 6
WC Nutrition & Dietetics; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics; Pharmacology & Pharmacy
GA DY2SS
UT WOS:000384942900008
DA 2025-06-11
ER

PT J
AU Palagini, L
   Bruno, RM
   Gemignani, A
   Baglioni, C
   Ghiadoni, L
   Riemann, D
AF Palagini, Laura
   Bruno, Rosa Maria
   Gemignani, Angelo
   Baglioni, Chiara
   Ghiadoni, Lorenzo
   Riemann, Dieter
TI Sleep Loss and Hypertension: A Systematic Review
SO CURRENT PHARMACEUTICAL DESIGN
LA English
DT Review
DE Sleep deprivation; short sleep duration; insomnia and hypertension
ID NUTRITION EXAMINATION SURVEY; JAPANESE MALE WORKERS; BLOOD-PRESSURE;
   METABOLIC SYNDROME; NATIONAL-HEALTH; INCIDENT HYPERTENSION; NORMOTENSIVE
   SUBJECTS; INSUFFICIENT SLEEP; CIRCADIAN-RHYTHM; CHRONIC INSOMNIA
AB Hypertension and insomnia are very common and often coexist. There is evidence to suggest that the increasing prevalence of arterial hypertension in the past decade might be related both to an increased prevalence of insomnia and to the decline of sleep duration due to modern lifestyle. The aim of this paper is to reconsider both the clinical evidence of the relationship between conditions of sleep loss and of perceived impairment in sleep quality with hypertension and the potential pathophysiological mechanisms underlying the biological plausibility of their relationship. Through a systematic search from MEDLINE, EMBASE, PsychINFO we selected articles, which reported experimental sleep deprivation designs, or studied sleep duration or insomnia and their relationship with blood pressure or hypertension in participants over 18 years. This analysis shows that experimental sleep deprivation, short sleep duration, and persistent insomnia are associated with increased blood pressure and increased risk of hypertension, even after controlling for other risk factors. Pathophysiological mechanisms underlying this association might be related to inappropriate arousal ("hyperarousal") due to an overactivation of stress system functions. According this hypothesis, prolonged sleep loss or alterations of sleep quality might act as a neurobiological and physiologic stressor that impair brain functions and contribute to allostatic load, compromising stress resilience and somatic health.
C1 [Palagini, Laura] Univ Pisa, Dept Psychiat Neurobiol Pharmacol & Biotechnol, I-56126 Pisa, Italy.
   [Bruno, Rosa Maria; Ghiadoni, Lorenzo] Univ Pisa, Dept Internal Med, I-56126 Pisa, Italy.
   [Bruno, Rosa Maria; Gemignani, Angelo] CNR, Inst Clin Physiol, Pisa, Italy.
   [Gemignani, Angelo] Univ Pisa, Dept Physiol Sci, I-56126 Pisa, Italy.
   [Gemignani, Angelo] Scuola Super Sant Anna, Extreme Ctr, Pisa, Italy.
   [Baglioni, Chiara; Riemann, Dieter] Univ Freiburg, Med Ctr, Dept Psychiat & Psychotherapy, Freiburg, Germany.
C3 University of Pisa; University of Pisa; Consiglio Nazionale delle
   Ricerche (CNR); Istituto di Fisiologia Clinica (IFC-CNR); University of
   Pisa; Scuola Superiore Sant'Anna; University of Freiburg
RP Palagini, L (corresponding author), Univ Pisa, Sch Med, Dept Psychiat Neurobiol Pharmacol & Biotechnol, Via Roma 67, I-56126 Pisa, Italy.
EM lpalagini@tiscali.it
RI Baglioni, Chiara/AAC-2605-2019; Palagini, Laura/AAC-6108-2022; Riemann,
   Dieter/R-4013-2019; Ghiadoni, Lorenzo/AAC-5176-2022; Gemignani,
   Angelo/AAC-3308-2022; Bruno, Rosa Maria/C-3594-2015
OI Bruno, Rosa Maria/0000-0002-6107-3356; Ghiadoni,
   Lorenzo/0000-0002-7399-2720; Riemann, Dieter/0000-0002-1968-6220;
   gemignani, angelo/0000-0001-7249-874X; Palagini,
   Laura/0000-0003-1676-629X
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NR 78
TC 200
Z9 217
U1 1
U2 78
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1381-6128
J9 CURR PHARM DESIGN
JI Curr. Pharm. Design
PD APR
PY 2013
VL 19
IS 13
BP 2409
EP 2419
DI 10.2174/1381612811319130009
PG 11
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Pharmacology & Pharmacy
GA 110QI
UT WOS:000316459700009
PM 23173590
DA 2025-06-11
ER

PT J
AU Nartea, A
   Orhotohwo, OL
   Fanesi, B
   Lucci, P
   Loizzo, MR
   Tundis, R
   Aquilanti, L
   Casavecchia, S
   Quattrini, G
   Pacetti, D
AF Nartea, Ancuta
   Orhotohwo, Oghenetega Lois
   Fanesi, Benedetta
   Lucci, Paolo
   Loizzo, Monica Rosa
   Tundis, Rosa
   Aquilanti, Lucia
   Casavecchia, Simona
   Quattrini, Giacomo
   Pacetti, Deborah
TI Sea fennel (Crithmum maritimum L.) leaves and flowers:
   Bioactive compounds, antioxidant activity and hypoglycaemic potential
SO FOOD BIOSCIENCE
LA English
DT Article
DE alpha-amylase; alpha-glucosidase; Carotenoids; Tocopherols; Lipase;
   Vitamin A; Vitamin E; Halophytes
ID METABOLIC SYNDROME; OXIDATIVE STRESS; FOOD
AB Sea fennel (Crithmum maritimum L.) leaves and flowers from Italian wild and cultivated populations were herein investigated for their content of carotenoids and tocopherols using ultra-high-performance liquid chromatography coupled with the photodiode array and fluorimeter detectors to assess their functional value. Moreover, aqueous extracts were prepared to explore in vitro bioactivities never tested in this halophyte herb. Thus, chlorogenic acid-enriched sea fennel extracts were evaluated for their major bioactive compounds, antioxidant potential, pancreatic lipase, and carbohydrate hydrolase inhibitors. Neoxanthin, violaxanthin, lutein, zeaxanthin, 13-carotene, and alpha- and gamma-tocopherols were identified. C. maritimum can be considered a high source of lutein, vitamin A, and vitamin E up to 19.1, 1.85 and 52.81 mg/100 g of dried leaves, respectively. Despite a low TPC content, a promising ABTS+. radical scavenging activity (CON-L-WT, IC50 value of 3.83 mu g/mL) and the highest FRAP value were observed in the wild leaves extract of Conero Park of Marche Region. The water extract from the wild Sicilian leaves was the most active against pancreatic lipase. The evidence herein suggests that sea fennel extract might be potentially used in the formulation of nutraceuticals for the prevention of diseases associated with oxidative stress and hyperglycemic conditions.
C1 [Nartea, Ancuta; Orhotohwo, Oghenetega Lois; Fanesi, Benedetta; Lucci, Paolo; Aquilanti, Lucia; Casavecchia, Simona; Quattrini, Giacomo; Pacetti, Deborah] Univ Politecn Marche, Dept Agr Food & Environm Sci, Ancona, Italy.
   [Loizzo, Monica Rosa; Tundis, Rosa] Univ Calabria, Dept Pharm Hlth & Nutr Sci, I-87036 Arcavacata Di Rende, CS, Italy.
C3 Marche Polytechnic University; University of Calabria
RP Pacetti, D (corresponding author), Univ Politecn Marche, Dept Agr Food & Environm Sci, Ancona, Italy.
EM d.pacetti@univpm.it
RI Simona, Casavecchia/ABH-2478-2020
OI Fanesi, Benedetta/0000-0002-7654-0973; Pacetti,
   Deborah/0000-0002-7223-4119
FU Italian Ministry of University and Research" (MUR); European Union
FX "This work was funded by the Italian Ministry of University and
   Research" (MUR) and part of the PRIMA programme supported by the
   European Union. Project title: "Innovative sustainable organic sea
   fennel (Crithmum maritimum L.) -based cropping systems to boost
   agro-biodiversity, profitability, circularity, and resilience to climate
   changes in Mediterranean small farms" (acronym: SEAFENNEL4MED,
   https://seafennel4med.com /) ".
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NR 54
TC 8
Z9 8
U1 2
U2 11
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2212-4292
EI 2212-4306
J9 FOOD BIOSCI
JI Food Biosci.
PD DEC
PY 2023
VL 56
AR 103417
DI 10.1016/j.fbio.2023.103417
EA DEC 2023
PG 10
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA DW2T6
UT WOS:001135060300001
OA hybrid
DA 2025-06-11
ER

PT J
AU Lopez-Santamarina, A
   Mondragon, AD
   Cardelle-Cobas, A
   Santos, EM
   Porto-Arias, JJ
   Cepeda, A
   Miranda, JM
AF Lopez-Santamarina, Aroa
   Mondragon, Alicia del Carmen
   Cardelle-Cobas, Alejandra
   Santos, Eva Maria
   Porto-Arias, Jose Julio
   Cepeda, Alberto
   Miranda, Jose Manuel
TI Effects of Unconventional Work and Shift Work on the Human Gut
   Microbiota and the Potential of Probiotics to Restore Dysbiosis
SO NUTRIENTS
LA English
DT Review
DE workers; gut microbiota; military; seafarers; healthcare; farmers;
   probiotics
ID IRRITABLE-BOWEL-SYNDROME; HEALTH-CARE WORKERS; SLEEP-DEPRIVATION; STRESS
   SYMPTOMS; IMPACT; ASSOCIATION; METABOLISM; DYNAMICS; CHILDREN; BACTERIA
AB The work environment is a factor that can significantly influence the composition and functionality of the gut microbiota of workers, in many cases leading to gut dysbiosis that will result in serious health problems. The aim of this paper was to provide a compilation of the different studies that have examined the influence of jobs with unconventional work schedules and environments on the gut microbiota of workers performing such work. As a possible solution, probiotic supplements, via modulation of the gut microbiota, can moderate the effects of sleep disturbance on the immune system, as well as restore the dysbiosis produced. Rotating shift work has been found to be associated with an increase in the risk of various metabolic diseases, such as obesity, metabolic syndrome, and type 2 diabetes. Sleep disturbance or lack of sleep due to night work is also associated with metabolic diseases. In addition, sleep disturbance induces a stress response, both physiologically and psychologically, and disrupts the healthy functioning of the gut microbiota, thus triggering an inflammatory state. Other workers, including military, healthcare, or metallurgy workers, as well as livestock farmers or long-travel seamen, work in environments and schedules that can significantly affect their gut microbiota.
C1 [Lopez-Santamarina, Aroa; Mondragon, Alicia del Carmen; Cardelle-Cobas, Alejandra; Porto-Arias, Jose Julio; Cepeda, Alberto; Miranda, Jose Manuel] Univ Santiago de Compostela, Dept Quim Analit Nutr & Bromatol, Lab Higiene Inspecc & Control Alimentos, Lugo 27002, Spain.
   [Santos, Eva Maria] Univ Autonoma Estado Hidalgo, Area Acad Quim, Carretera Pachuca-Tulancingo km 4-5, Pachuca 42076, Hidalgo, Mexico.
C3 Universidade de Santiago de Compostela; Universidad Autonoma del Estado
   de Hidalgo
RP Cepeda, A (corresponding author), Univ Santiago de Compostela, Dept Quim Analit Nutr & Bromatol, Lab Higiene Inspecc & Control Alimentos, Lugo 27002, Spain.
EM aroa.lopez.santamarina@usc.es; alicia.mondragon@usc.es;
   alejandra.cardelle@usc.es; emsantos@uaeh.edu.mx;
   josejulio.porto@usc.gal; alberto.cepeda@usc.es;
   josemanuel.miranda@usc.es
RI Miranda, Jose/I-2040-2019; Santos, Eva M/C-7219-2015; Cepeda,
   Alberto/M-4595-2018; Cardelle Cobas, Alejandra/K-7183-2017
OI miranda, jose/0000-0001-7992-1491; Lopez Santamarina,
   Aroa/0000-0002-2159-1474; Santos, Eva M/0000-0002-3803-2820; Cepeda,
   Alberto/0000-0002-9324-1342; Cardelle Cobas,
   Alejandra/0000-0002-1271-513X; Mondragon Portocarrero, Alicia del
   Carmen/0000-0003-1274-5539
FU European Regional Development Funds (FEDER) [ED431C 2018/05]
FX The authors thank the Xunta de Galicia and European Regional Development
   Funds (FEDER), grant ED431C 2018/05, for covering the cost of this
   study.
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NR 102
TC 9
Z9 9
U1 3
U2 8
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JUL
PY 2023
VL 15
IS 13
AR 3070
DI 10.3390/nu15133070
PG 19
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA M2CX9
UT WOS:001028324400001
PM 37447396
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Tang, C
   Cao, G
   Zhao, W
   Bie, XM
   Lu, FX
   Lu, ZX
   Lu, YJ
AF Tang, Chao
   Cao, Gang
   Zhao, Wen
   Bie, Xiaomei
   Lu, Fengxia
   Lu, Zhaoxin
   Lu, Yingjian
TI Lactobacillus acidophilus NX2-6 Improved High-Fat Diet-Induced
   Glucose Metabolism Disorder Independent of Promotion of Insulin
   Secretion in Mice
SO JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
LA English
DT Article
DE Lactobacillus acidophilus NX2-6; insulin resistance; inflammatory
   cascades; energy metabolism; intestinal gluconeogenesis; glucose uptake
ID GROWTH-FACTOR 21; LIVER; INFLAMMATION; SENSITIVITY; EXPRESSION;
   RESISTANCE; MICROBIOTA; STRESS
AB High-fat diet (HFD) contributes to metabolic inflammation and glucose metabolism disorder, thereby resulting in the pathogenesis of metabolic syndrome. Accumulating evidence has revealed that some probiotics could improve HFD-induced metabolic inflammation and glucose metabolism disorder. Our previous study has discovered that Lactobacillus acidophilus NX2-6 exhibited in vitro lipid-lowering, antioxidative, and anti-inflammatory activities. This study mainly investigated whether L. acidophilus NX2-6 improved HFD-induced glucose metabolism disorder. The results exhibited that L. acidophilus NX2-6 effectively reduced blood glucose levels and improved glucose tolerance by activating the insulin signaling pathway, promoting glucose uptake, glycolysis, and intestinal gluconeogenesis and suppressing hepatic gluconeogenesis, independent of regulation of glycogen synthesis in the liver and muscle. Enhanced insulin sensitivity was associated with L. acidophilus NX2-6-mediated suppression of inflammatory cascades in the target organs. Meanwhile, L. acidophilus NX2-6 also improved hepatic energy metabolism via the FGF21/AMPK alpha/PGC-1 alpha/NRF1 pathway. However, L. acidophilus NX2-6 did not affect apoptosis, pyroptosis, inflammation, and endoplasmic reticulum stress in the pancreas of HFD-fed mice. In conclusion, our results indicated that L. acidophilus NX2-6 improved glucose metabolism disorder through enhancing insulin sensitivity, suppressing metabolic inflammation, and promoting energy expenditure.
C1 [Tang, Chao; Cao, Gang; Zhao, Wen; Bie, Xiaomei; Lu, Fengxia; Lu, Zhaoxin] Nanjing Agr Univ, Coll Food Sci & Technol, Nanjing 210095, Jiangsu, Peoples R China.
   [Lu, Yingjian] Nanjing Univ Finance & Econ, Coll Food Sci & Engn, Nanjing 210023, Jiangsu, Peoples R China.
C3 Nanjing Agricultural University; Nanjing University of Finance &
   Economics
RP Lu, ZX (corresponding author), Nanjing Agr Univ, Coll Food Sci & Technol, Nanjing 210095, Jiangsu, Peoples R China.; Lu, YJ (corresponding author), Nanjing Univ Finance & Econ, Coll Food Sci & Engn, Nanjing 210023, Jiangsu, Peoples R China.
EM fmb@njau.edu.cn; yingjianlu@nufe.edu.cn
RI Lu, Yingjian/O-9008-2014
OI Lu, Yingjian/0000-0001-6425-2774; Tang, Chao/0000-0002-7216-1917
FU National Natural Science Foundation of China [32072182]
FX The authors acknowledge the financial support for this work provided by
   the National Natural Science Foundation of China (no. 32072182).
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NR 52
TC 18
Z9 20
U1 5
U2 47
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0021-8561
EI 1520-5118
J9 J AGR FOOD CHEM
JI J. Agric. Food Chem.
PD DEC 29
PY 2021
VL 69
IS 51
BP 15598
EP 15610
DI 10.1021/acs.jafc.1c05948
PG 13
WC Agriculture, Multidisciplinary; Chemistry, Applied; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture; Chemistry; Food Science & Technology
GA YS7XW
UT WOS:000750887700016
PM 34788040
DA 2025-06-11
ER

PT J
AU Yang, RJ
   Yu, J
AF Yang, Ruijin
   Yu, Jun
TI Evaluation of the Associations between Vascular Endothelial Function and
   Coronary Artery Stenosis in Patients with Elevated Blood Pressure during
   Coronary Angiography
SO HEART SURGERY FORUM
LA English
DT Article; Proceedings Paper
CT 2nd Scientific Congress of Heart Surgery Forum
CY MAY 14-17, 2014
CL Split, CROATIA
ID ESSENTIAL-HYPERTENSION; METABOLIC SYNDROME; NITRIC-OXIDE; IN-VIVO;
   DISEASE; ATHEROSCLEROSIS; RELAXATIONS; DYSFUNCTION; OBESITY
AB Objectives: The aim of the present study is to explore the correlation between vascular endothelial function and coronary artery stenosis in non-hypertensive patients with elevated blood pressure under stress.
   Methods: This study included 1141 patients suspected of having coronary artery disease (CAD) without hypertension. Coronary arteriography and ultrasonic detection were used to measure the flow-mediated dilatation (FMD) function in the brachial artery. Patients were divided into 2 groups according to coronary angiography: experiment group, patients with blood pressure >= 140/90 mm Hg; control group, patients with blood pressure < 140/90 mm Hg. The correlation between vascular endothelial function and coronary artery stenosis was observed.
   Results: The majority of the patients in the control group were found to have either normal coronary arteries or stenosis < 50%. Patients in the experiment group (those with invasive blood pressure [IBP] > 140/90) were more likely to have some degree of coronary artery stenosis. Specifically, there were significantly more patients with > 50% stenosis in the experiment when compared with the control group (P < .05). The FMD in the experiment group was significantly lower than that in the control group (P < .05).
   Conclusion: The non-hypertensive patients with elevated blood pressure under stress had coronary artery stenosis, which was associated with vascular endothelial dysfunction.
C1 [Yang, Ruijin; Yu, Jun] Chinese Peoples Liberat Army, Hosp 3, Dept Cardiol, Baoji 721004, Peoples R China.
RP Yu, J (corresponding author), Chinese Peoples Liberat Army, Hosp 3, Dept Cardiol, Baoji 721004, Peoples R China.
EM yujun197@163.com
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NR 21
TC 1
Z9 1
U1 0
U2 2
PU FORUM MULTIMEDIA PUBLISHING, LLC
PI CHARLOTTESVILLE
PA 375 GREENBRIER DR, CHARLOTTESVILLE, VA 22901 USA
SN 1098-3511
EI 1522-6662
J9 HEART SURG FORUM
JI Heart Surg. Forum
PD JUN
PY 2014
VL 17
IS 3
BP E150
EP E153
DI 10.1532/HSF98.2013265
PG 4
WC Cardiac & Cardiovascular Systems; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Cardiovascular System & Cardiology; Surgery
GA AL2VN
UT WOS:000338983800007
PM 25002391
DA 2025-06-11
ER

PT J
AU Azizi, B
   Mohseni, S
   Tabatabaei-Malazy, O
   Esmaeili, F
   Khodaeian, M
   Qorbani, M
   Nazeri, E
   Nouhi, Z
AF Azizi, Bayan
   Mohseni, Shahrzad
   Tabatabaei-Malazy, Ozra
   Esmaeili, Fataneh
   Khodaeian, Mehrnoosh
   Qorbani, Mostafa
   Nazeri, Elahe
   Nouhi, Zahra
TI Meta-analysis of the anti-oxidative and anti-inflammatory effects of
   hypoglycaemic plant-derived medicines
SO INFLAMMOPHARMACOLOGY
LA English
DT Article
DE Type 2 diabetes mellitus; Inflammation; Oxidative stress; Plant-derived;
   Clinical trial; Systematic review
ID TYPE-2 DIABETES-MELLITUS; OXIDATIVE STRESS BIOMARKERS; DOUBLE-BLIND;
   ENDOTHELIAL DYSFUNCTION; EXTRACT SUPPLEMENTATION; CARDIOVASCULAR RISK;
   DIETARY POLYPHENOLS; PHYLLANTHUS-EMBLICA; METABOLIC-RESPONSE; GLYCEMIC
   CONTROL
AB BackgroundThe pivotal role of oxidative stress and inflammation in the pathophysiology of type 2 diabetes mellitus (T2DM) has been firmly established. However, the evidence concerning hypoglycaemic medicinal plants' antioxidant and anti-inflammatory effects remains inconclusive due to inconsistencies in prior studies. To address this gap, our study aims to perform a comprehensive systematic review and meta-analysis of randomized controlled trials (RCTs) to consolidate previous research findings in this field.MethodsWe conducted a comprehensive search in the PubMed, Web of Science, Embase, Cochrane Library, and Scopus databases to identify relevant English randomized controlled trials (RCTs). Our study adhered to the Preferred Reporting Items for Systematic Review and Meta-analysis (PRISMA) guidelines. All eligible studies that evaluated concurrently the antioxidative and anti-inflammatory effects of hypoglycaemic plant-derived supplements on type 2 diabetes mellitus (T2DM) were included in the meta-analysis. The meta-analysis itself was carried out using both fixed and random effects models to synthesize the findings from the selected studies.ResultsOur study included 47 trials with a total of 2636 participants, both male and female, aged between 20 and 79 years, diagnosed with prediabetes, type 2 diabetes mellitus (T2DM), or metabolic syndrome. The meta-analysis revealed that plant-derived treatments, compared to placebos or other medicines, significantly improved oxidative stress (SMD = - 0.36, 95% CI - 0.64 to - 0.09), inflammation (SMD = - 0.47, 95% CI - 0.63 to - 0.31), total antioxidant capacity (SMD = 0.46, 95% CI 0.16-0.75), and antioxidant enzyme activity (SMD = 1.80, 95% CI 1.26-2.33). The meta-regression analysis showed that treatment duration exceeding 8 weeks significantly impacted the heterogeneity of the oxidative stress data.ConclusionsSeveral hypoglycaemic plant-based treatments appear to positively affect T2DM patients by concurrently lowering oxidative stress and inflammatory indicators and boosting antioxidant enzyme activity.Clinical Trail RegistryPROSPERO ID: CRD42021226147.
C1 [Azizi, Bayan] Univ Tehran Med Sci, Endocrinol & Metab Clin Sci Inst, Diabet Res Ctr, Tehran 1411413137, Iran.
   [Azizi, Bayan] Univ Tehran Med Sci, Cardiovasc Dis Res Inst, Cardiac Primary Prevent Res Ctr CPPRC, Tehran, Iran.
   [Mohseni, Shahrzad; Khodaeian, Mehrnoosh; Nazeri, Elahe; Nouhi, Zahra] Univ Tehran Med Sci, Endocrinol & Metab Clin Sci Inst, Endocrinol & Metab Res Ctr, Tehran, Iran.
   [Tabatabaei-Malazy, Ozra] Univ Tehran Med Sci, Endocrinol & Metab Populat Sci Inst, Noncommunicable Dis Res Ctr, Tehran, Iran.
   [Esmaeili, Fataneh] Univ Tehran Med Sci, Fac Med, Dept Clin Biochem, Tehran, Iran.
   [Esmaeili, Fataneh] Univ Tehran Med Sci, Student Sci Res Ctr, Tehran, Iran.
   [Qorbani, Mostafa] Alborz Univ Med Sci, Noncommunicable Dis Res Ctr, Karaj, Iran.
C3 Tehran University of Medical Sciences; Tehran University of Medical
   Sciences; Tehran University of Medical Sciences; Tehran University of
   Medical Sciences; Tehran University of Medical Sciences; Tehran
   University of Medical Sciences; Alborz University of Medical Sciences
RP Tabatabaei-Malazy, O (corresponding author), Univ Tehran Med Sci, Endocrinol & Metab Populat Sci Inst, Noncommunicable Dis Res Ctr, Tehran, Iran.
EM bayan.azizi@ymail.com; shmohseni58@gmail.com;
   tabatabaeiml@sina.tums.ac.ir; fatanehesmaeili69@gmail.com;
   mehrnoosh657@gmail.com; mqorbani1379@yahoo.com; nazeri_elahe@yahoo.com;
   zahra_nouhi@yahoo.com
RI Tabatabaei-Malazy, ozra/T-5561-2017; Nazeri, Elahe/GZM-5620-2022;
   Khodaeian, Mehrnoosh/AAR-1751-2021; Qorbani, Mostafa/M-8171-2017;
   Tabatabaei, ozra/E-3634-2013
OI Khodaeian, Mehrnoosh/0000-0001-6064-018X; mohseni,
   shahrzad/0000-0002-0694-7495; Tabatabaei, ozra/0000-0003-0188-9721;
   Esmaeili, Fataneh/0000-0003-0047-4321; nazeri, elahe/0000-0003-0956-8375
FU All authors thank Endocrinology and Metabolism Clinical Sciences
   Institute for its financial support. It should be noted that the
   institute had no role in any part of the study, writing of the
   manuscript, or the decision to submit.; Endocrinology and Metabolism
   Clinical Sciences Institute
FX All authors thank Endocrinology and Metabolism Clinical Sciences
   Institute for its financial support. It should be noted that the
   institute had no role in any part of the study, writing of the
   manuscript, or the decision to submit.
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NR 73
TC 0
Z9 0
U1 1
U2 2
PU SPRINGER BASEL AG
PI BASEL
PA PICASSOPLATZ 4, BASEL, 4052, SWITZERLAND
SN 0925-4692
EI 1568-5608
J9 INFLAMMOPHARMACOLOGY
JI Inflammopharmacology
PD OCT
PY 2023
VL 31
IS 5
BP 2521
EP 2539
DI 10.1007/s10787-023-01315-9
EA SEP 2023
PG 19
WC Immunology; Pharmacology & Pharmacy; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Pharmacology & Pharmacy; Toxicology
GA S8JK9
UT WOS:001057085500001
PM 37658968
DA 2025-06-11
ER

PT J
AU Zhao, LL
   Wu, T
   Li, JY
   Cai, CY
   Yao, QQ
   Zhu, YS
AF Zhao, Lulu
   Wu, Tong
   Li, Jiayi
   Cai, Chunyan
   Yao, Qingqiang
   Zhu, Yi-Shen
TI Data-independent acquisition-based proteomics analysis correlating type
   2 diabetes mellitus with osteoarthritis in total knee arthroplasty
   patients
SO MEDICINE
LA English
DT Article
DE chronic inflammation; diabetes mellitus; osteoarthritis; oxidative
   stress; proteomics
ID METABOLIC SYNDROME; SIGNALING PATHWAY; INFLAMMATION; HYPOXIA; CELLS
AB Background: To explore the effects of type 2 diabetes mellitus (T2DM) on osteoarthritis (OA), 12 bone tissue samples were obtained surgically from the human total knee arthroplasty patients and analyzed by quantitative proteomics. Methods: Based on patient clinical histories, patient samples were assigned to diabetes mellitus osteoarthritis (DMOA) and OA groups. A data-independent acquisition method for data collection was used with proteomic data analysis to assess intergroup proteomic differences. Gene Ontology (GO) functional analysis and Kyoto Encyclopedia of Genes and Genome pathway enrichment analysis were used to further find the correlation between T2DM and OA. Results: GO functional analysis found 153 differentially expressed proteins between DMOA and OA groups, of which 92 differentially expressed proteins were significantly up-regulated and 61 were significantly down-regulated. Kyoto Encyclopedia of Genes and Genome pathway analysis found 180 pathways, including 9 pathways significantly enriched. Further data analysis revealed that 6 signaling pathways were closely associated with T2DM and OA. Conclusion: OA and DMOA onset and progression were closely related to synthesis and metabolism of extracellular matrix components (e.g., fibronectin, decorin, etc.). The effects of T2DM on OA occur though 2 major ways of oxidative stress and low-grade chronic inflammation, involving in 2 inhibited signaling pathways and 4 activated signaling pathways.
C1 [Zhao, Lulu; Cai, Chunyan] Nanjing Tech Univ, Sch Pharmaceut Sci, Nanjing, Jiangsu, Peoples R China.
   [Wu, Tong; Zhu, Yi-Shen] Nanjing Tech Univ, Coll Biotechnol & Pharmaceut Engn, 30 Pu Zhu South Rd, Nanjing 211816, Jiangsu, Peoples R China.
   [Li, Jiayi; Yao, Qingqiang] Nanjing Med Univ, Dept Orthoped Surg, Nanjing Hosp 1, Nanjing, Jiangsu, Peoples R China.
   [Yao, Qingqiang] Nanjing Med Univ, Inst Digital Med, Key Lab Addit Mfg Technol, Nanjing, Jiangsu, Peoples R China.
C3 Nanjing Tech University; Nanjing Tech University; Nanjing Medical
   University; Nanjing Medical University
RP Zhu, YS (corresponding author), Nanjing Tech Univ, Coll Biotechnol & Pharmaceut Engn, 30 Pu Zhu South Rd, Nanjing 211816, Jiangsu, Peoples R China.
EM zhuyish@njtech.edu.cn
RI Zhu, yishen/AAB-3864-2020
OI Zhu, Yi-Shen/0000-0002-2616-8501
FU Key Project of Social Development of Jiangsu Province [BE2019736];
   National Natural Science Foundation of China [82072400]; Natural Science
   Foundation of Jiangsu Province [BK20200001]; Natural Science Foundation
   of Hunan Province [BK20200144]
FX This work was supported by grants from the Key Project of Social
   Development of Jiangsu Province (BE2019736), the National Natural
   Science Foundation of China (82072400), Natural Science Foundation of
   Jiangsu Province (BK20200001) and Natural Science Foundation of Hunan
   Province (BK20200144).
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NR 36
TC 2
Z9 2
U1 1
U2 14
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD FEB 4
PY 2022
VL 101
IS 5
AR e28738
DI 10.1097/MD.0000000000028738
PG 9
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA YS9LF
UT WOS:000750992000031
PM 35119024
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Shin, MS
   Shin, HS
   Ahn, YB
   Kim, HD
AF Shin, Myung-Seop
   Shin, Hye-Sun
   Ahn, Yoo-Been
   Kim, Hyun-Duck
TI Association between periodontitis and salivary 8-hydroxydeoxyguanosine
   among Korean rural adults
SO COMMUNITY DENTISTRY AND ORAL EPIDEMIOLOGY
LA English
DT Article
DE 8-OHdG; epidemiology; oxidative stress; periodontitis; saliva
ID GINGIVAL CREVICULAR FLUID; OXIDATIVE DNA-DAMAGE; METABOLIC SYNDROME;
   REACTIVE OXYGEN; NITRIC-OXIDE; STRESS; RISK; BIOMARKERS; DISEASE; STROKE
AB ObjectivesThis study aimed to evaluate the association between salivary 8-hydroxydeoxyguanosine (8-OHdG) and periodontitis among community-dwelling Korean adults.
   MethodsA total of 211 adults (80 men and 131 women) were cross-sectionally surveyed from the Sunchang Longevity Cohort. Periodontitis was defined as having at least 30% of teeth with proximal attachment loss 5 mm. The salivary 8-OHdG level was categorized into tertiles: low (<0.916 ng/ml), medium (0.916 to <2.675 ng/ml) and high (2.675 ng/ml). Sociodemographic, habitual and systemic health-related factors were controlled for. Logistic regression analysis was performed for the outcome of severe periodontitis. Analysis of covariance in general linear model was performed for the outcome of 8-OHdG.
   ResultsThe high 8-OHdG level showed a significant association with periodontitis. The odds ratio (95% confidence interval) was 2.40 (1.05-5.51), and it was highlighted by adding the interaction term with drinking and smoking. The adjusted mean log-transformed value of 8-OHdG was significantly higher in the severe periodontitis group (1.40 ng/ml) than in the control group (1.02 ng/ml) (ancova, P = 0.028).
   Conclusions8-OHdG was associated with periodontitis. Thus, salivary 8-OHdG could be a useful marker for periodontitis.
C1 [Shin, Myung-Seop; Shin, Hye-Sun; Ahn, Yoo-Been; Kim, Hyun-Duck] Seoul Natl Univ, Sch Dent, Dept Prevent & Social Dent, 101 Daehak Ro, Seoul 110749, South Korea.
   [Kim, Hyun-Duck] Seoul Natl Univ, Sch Dent, Dent Res Inst, Seoul, South Korea.
C3 Seoul National University (SNU); Seoul National University (SNU)
RP Kim, HD (corresponding author), Seoul Natl Univ, Sch Dent, Dept Prevent & Social Dent, 101 Daehak Ro, Seoul 110749, South Korea.
EM hyundkim@snu.ac.kr
RI Shin, Hye-Sun/GXV-1170-2022
FU National Research Foundation of Korea through the Oromaxillofacial
   Dysfunction Research Center for the Elderly at Seoul National University
   in Korea [2014-050477]; National Research Foundation of Korea (NRF) -
   Ministry of Education, Science and Technology [2013-062881]; Brain Korea
   21 at Seoul National University School of Dentistry in Korea
FX The authors declared that there are no conflicts of interest in this
   study. This research was supported by the National Research Foundation
   of Korea, through the Oromaxillofacial Dysfunction Research Center for
   the Elderly (#2014-050477) at Seoul National University in Korea and
   Basic Science Research Program through the National Research Foundation
   of Korea (NRF) funded by the Ministry of Education, Science and
   Technology (#2013-062881). Ms. Shin and Dr. Ahn were supported by the
   grants from Brain Korea 21 at Seoul National University School of
   Dentistry in Korea.
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NR 37
TC 8
Z9 9
U1 0
U2 10
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0301-5661
EI 1600-0528
J9 COMMUNITY DENT ORAL
JI Community Dentist. Oral Epidemiol.
PD AUG
PY 2016
VL 44
IS 4
BP 381
EP 389
DI 10.1111/cdoe.12225
PG 9
WC Dentistry, Oral Surgery & Medicine; Public, Environmental & Occupational
   Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dentistry, Oral Surgery & Medicine; Public, Environmental & Occupational
   Health
GA DR4WE
UT WOS:000379903000008
PM 26919660
DA 2025-06-11
ER

PT J
AU Berisha, H
   Hattab, R
   Comi, L
   Giglione, C
   Migliaccio, S
   Magni, P
AF Berisha, Hygerta
   Hattab, Reham
   Comi, Laura
   Giglione, Claudia
   Migliaccio, Silvia
   Magni, Paolo
TI Nutrition and Lifestyle Interventions in Managing Dyslipidemia and
   Cardiometabolic Risk
SO NUTRIENTS
LA English
DT Review
DE nutritional management; dyslipidemia; cardiovascular risk; metabolic
   risk; cholesterol; triglycerides; lifestyle interventions
ID MEDITERRANEAN DIET; CARDIOVASCULAR RISK; HEALTH; ATHEROSCLEROSIS;
   RECOMMENDATIONS; PATHWAYS; DISEASE
AB Dyslipidemia, characterized by abnormal blood lipid levels, is a major public health concern due to its association with atherosclerotic cardiovascular disease (ASCVD) and other cardiometabolic disorders. In this context, appropriate nutrition patterns are pivotal as they represent the basic approach for providing a wide range of substantial advantages. The best evidence for dyslipidemia management is offered by the Mediterranean Diet, the Plant-Based Diet, the High-Fiber Diet and the Anti-inflammatory Diet, while the DASH Diet and the Ketogenic Diet have also been shown to target additional pathological features like hypertension and other comorbidities. The bioactive compounds that are enriched in these nutrition patterns and able to manage dyslipidemia include monounsaturated fatty acids such as omega-3, polyphenols such as oleuropein, resveratrol, flavonoids, and catechins, carotenoids, phytosterols and soluble and unsoluble fibers. Diets rich in these compounds can improve lipid profile by mitigating oxidative stress, reducing low-grade chronic inflammation, modulating macronutrient absorption and other mechanisms, thereby supporting cardiovascular health. Additionally, lifestyle interventions such as regular physical activity, weight loss, reduced alcohol consumption and smoking cessation further ameliorate lipid metabolism and manage circulated lipid profile. Furthermore, emerging insights from nutrigenomics underscore the potential for proper diet to address genetic factors and optimize treatment outcomes. The pivotal role of nutrition interventions in the context of dyslipidemia and its cardiometabolic implications is discussed in this review, emphasizing evidence-based and personalized approaches.
C1 [Berisha, Hygerta; Hattab, Reham; Comi, Laura; Giglione, Claudia; Magni, Paolo] Univ Milan, Dipartimento Sci Farmacolog & Biomolecolari, I-20133 Milan, Italy.
   [Migliaccio, Silvia] Sapienza Univ Roma, Dipartimento Med Sperimentale, I-00185 Rome, Italy.
   [Magni, Paolo] IRCCS Multimed, I-20099 Milan, Italy.
C3 University of Milan; Sapienza University Rome; IRCCS Multimedica
RP Magni, P (corresponding author), Univ Milan, Dipartimento Sci Farmacolog & Biomolecolari, I-20133 Milan, Italy.; Magni, P (corresponding author), IRCCS Multimed, I-20099 Milan, Italy.
EM hygerta.berisha@unimi.it; reham.hattab@unimi.it; laura.comi1@unimi.it;
   claudia.giglione@unimi.it; silvia.migliaccio@uniroma1.it;
   paolo.magni@unimi.it
OI MAGNI, PAOLO/0000-0002-2254-8881
FU European Union; Italian Space Agency (ASI) [2023-7-HH.0 CUP
   F13C23000050005 MicroFunExpo]; Italian Ministry of Health
   [PNRR-MCNT2-2023-12377808, PNRR: M6/C2_CALL 2023]; Italian Ministry of
   University and Research;  [CardioSCOPE
   10108639-HORIZON-MSCA-2021-SE-01-01];  [CA21153]
FX The work of P.M. is supported in part by the European Union (CardioSCOPE
   10108639-HORIZON-MSCA-2021-SE-01-01 MSCA Staff Exchanges 2021, AtheroNET
   COST Action CA21153), the Italian Space Agency (ASI; N. 2023-7-HH.0 CUP
   F13C23000050005 MicroFunExpo) and the Italian Ministry of Health
   (project PNRR-MCNT2-2023-12377808, PNRR: M6/C2_CALL 2023). H.B., R.H.,
   L.C. and C.G. are supported in part by the Italian Ministry of
   University and Research.
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NR 98
TC 2
Z9 2
U1 5
U2 5
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD MAR
PY 2025
VL 17
IS 5
AR 776
DI 10.3390/nu17050776
PG 13
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA Z9Z4B
UT WOS:001442396700001
PM 40077646
OA gold
DA 2025-06-11
ER

PT J
AU Citriniti, EL
   Rocca, R
   Costa, G
   Renzi, G
   Carta, F
   Supuran, CT
   Alcaro, S
   Ortuso, F
AF Citriniti, Emanuele Liborio
   Rocca, Roberta
   Costa, Giosue
   Renzi, Gioele
   Carta, Fabrizio
   Supuran, Claudiu T.
   Alcaro, Stefano
   Ortuso, Francesco
TI Dual inhibition of carbonic anhydrases VA and VII by silychristin and
   isosilybin A from Silybum marianum: A potential antiobesity
   strategy
SO ARCHIV DER PHARMAZIE
LA English
DT Article
DE docking; dual inhibition; hCAs; milk thistle; obesity
ID IN-VITRO; SILYMARIN; OBESITY; TOOLS
AB Obesity is a global health crisis linked to chronic diseases like cardiovascular disease and type 2 diabetes. Its prevalence, even in low-income countries, highlights the failure of traditional interventions. Safer pharmacological treatments are urgently needed, as many existing antiobesity drugs have been withdrawn due to severe side effects, leaving a critical therapeutic gap. A promising target in this context is human carbonic anhydrase V (hCA V), a mitochondrial enzyme that plays a key role in glucose homeostasis. Inhibiting hCA V has been shown to reduce lipogenesis and improve metabolic conditions. Natural plant extracts, such as silymarin from milk thistle, have demonstrated potential in managing obesity-related metabolic syndromes by lowering triglycerides, reducing cholesterol levels, and improving liver function. Our computational studies have identified active compounds in silymarin that effectively inhibit hCA V, shedding light on a potential mechanism for its antiobesity effects. Building on these findings, our research further reveals that these compounds also inhibit carbonic anhydrase VII (hCA VII), enhancing their therapeutic potential. This dual inhibitory action addresses both metabolic dysregulation and oxidative stress. Notably, the antioxidant properties of hCA VII provide additional protection against obesity-related complications by mitigating oxidative stress, a key contributor to the development of metabolic syndrome.
C1 [Citriniti, Emanuele Liborio; Rocca, Roberta; Costa, Giosue; Alcaro, Stefano; Ortuso, Francesco] Magna Graecia Univ Catanzaro, Dipartimento Sci Salute, Viale Europa, I-88100 Catanzaro, Italy.
   [Rocca, Roberta; Costa, Giosue; Alcaro, Stefano; Ortuso, Francesco] Magna Graecia Univ Catanzaro, Net4Science Srl, Catanzaro, Italy.
   [Rocca, Roberta; Alcaro, Stefano] Assoc CRISEA Ctr Ric & Serv Avanzati Innovaz Rural, Catanzaro, Italy.
   [Renzi, Gioele; Carta, Fabrizio; Supuran, Claudiu T.] Univ Florence, NEUROFARBA Dept, Sez Sci Farmaceut, Florence, Italy.
C3 Magna Graecia University of Catanzaro; Magna Graecia University of
   Catanzaro; University of Florence
RP Rocca, R (corresponding author), Magna Graecia Univ Catanzaro, Dipartimento Sci Salute, Viale Europa, I-88100 Catanzaro, Italy.
EM rocca@unicz.it
RI Rocca, Roberta/L-7431-2016; Supuran, Claudiu/A-5151-2008; carta,
   fabrizio/Y-2333-2019; Costa, Giosue/K-8461-2016
OI carta, fabrizio/0000-0002-1141-6146; Costa, Giosue/0000-0003-0947-9479;
   Supuran, Claudiu/0000-0003-4262-0323; ALCARO,
   Stefano/0000-0002-0437-358X; Rocca, Roberta/0000-0002-0680-7097
FU PON "Ricerca e Innovazione" 2014-2020 [26, DOT13C5773-4]
FX PON "Ricerca e Innovazione" 2014-2020, grant number No. 26" code
   DOT13C5773-4
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NR 60
TC 0
Z9 0
U1 2
U2 2
PU WILEY-V C H VERLAG GMBH
PI WEINHEIM
PA POSTFACH 101161, 69451 WEINHEIM, GERMANY
SN 0365-6233
EI 1521-4184
J9 ARCH PHARM
JI Arch. Pharm.
PD MAR
PY 2025
VL 358
IS 3
AR e2400966
DI 10.1002/ardp.202400966
PG 10
WC Chemistry, Medicinal; Chemistry, Multidisciplinary; Pharmacology &
   Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Chemistry
GA 0LJ2H
UT WOS:001450121300001
PM 40123420
OA hybrid
DA 2025-06-11
ER

PT J
AU Chitimus, DM
   Popescu, MR
   Voiculescu, SE
   Panaitescu, AM
   Pavel, B
   Zagrean, L
   Zagrean, AM
AF Chitimus, Diana Maria
   Popescu, Mihaela Roxana
   Voiculescu, Suzana Elena
   Panaitescu, Anca Maria
   Pavel, Bogdan
   Zagrean, Leon
   Zagrean, Ana-Maria
TI Melatonin's Impact on Antioxidative and Anti-Inflammatory Reprogramming
   in Homeostasis and Disease
SO BIOMOLECULES
LA English
DT Review
DE melatonin; antioxidant; homeostasis; allostasis; maternal-fetal
   signaling; COVID 19; cardiovascular; neurodegenerative
ID ISCHEMIA-REPERFUSION INJURY; OXIDATIVE STRESS; MYOCARDIAL-ISCHEMIA; DNA
   METHYLATION; ENDOTHELIAL DYSFUNCTION; NEUROPROTECTIVE ROLE;
   ALZHEIMERS-DISEASE; PERINATAL ASPHYXIA; MATERNAL MELATONIN;
   BLOOD-PRESSURE
AB There is a growing consensus that the antioxidant and anti-inflammatory properties of melatonin are of great importance in preserving the body functions and homeostasis, with great impact in the peripartum period and adult life. Melatonin promotes adaptation through allostasis and stands out as an endogenous, dietary, and therapeutic molecule with important health benefits. The anti-inflammatory and antioxidant effects of melatonin are intertwined and are exerted throughout pregnancy and later during development and aging. Melatonin supplementation during pregnancy can reduce ischemia-induced oxidative damage in the fetal brain, increase offspring survival in inflammatory states, and reduce blood pressure in the adult offspring. In adulthood, disturbances in melatonin production negatively impact the progression of cardiovascular risk factors and promote cardiovascular and neurodegenerative diseases. The most studied cardiovascular effects of melatonin are linked to hypertension and myocardial ischemia/reperfusion injury, while the most promising ones are linked to regaining control of metabolic syndrome components. In addition, there might be an emerging role for melatonin as an adjuvant in treating coronavirus disease 2019 (COVID 19). The present review summarizes and comments on important data regarding the roles exerted by melatonin in homeostasis and oxidative stress and inflammation related pathologies.
C1 [Chitimus, Diana Maria; Voiculescu, Suzana Elena; Pavel, Bogdan; Zagrean, Leon; Zagrean, Ana-Maria] Carol Davila Univ Med & Pharm, Dept Funct Sci, Div Physiol & Neurosci, Bucharest 010164, Romania.
   [Popescu, Mihaela Roxana] Carol Davila Univ Med & Pharm, Elias Univ Hosp, Dept Cardiol, Bucharest 010164, Romania.
   [Panaitescu, Anca Maria] Carol Davila Univ Med & Pharm, Dept Obstet & Gynecol, Filantropia Clin Hosp, Bucharest 010164, Romania.
C3 Carol Davila University of Medicine & Pharmacy; Carol Davila University
   of Medicine & Pharmacy; Carol Davila University of Medicine & Pharmacy
RP Zagrean, AM (corresponding author), Carol Davila Univ Med & Pharm, Dept Funct Sci, Div Physiol & Neurosci, Bucharest 010164, Romania.
EM diana.chitimus@rez.umfcd.ro; roxana.popescu@umfcd.ro;
   suzana.voiculescu@umfcd.ro; anca.panaitescu@umfcd.ro;
   bogdan.pavel@umfcd.ro; leon.zagrean@umfcd.ro; ana-maria.zagrean@umfcd.ro
RI Panaitescu, Anca/Y-7332-2018; Chitimus, Diana/AAM-5904-2020; Pavel,
   Bogdan/ADQ-5483-2022; Popescu, Mihaela/AAD-6433-2019; Zagrean,
   Ana-Maria/M-5628-2015
OI Popescu, Mihaela/0000-0002-4539-5259; Pavel, Bogdan/0000-0002-7238-9946;
   Zagrean, Ana-Maria/0000-0002-4302-629X; Chitimus,
   Diana/0000-0003-3241-2782
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NR 220
TC 203
Z9 215
U1 1
U2 31
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2218-273X
J9 BIOMOLECULES
JI Biomolecules
PD SEP
PY 2020
VL 10
IS 9
AR 1211
DI 10.3390/biom10091211
PG 28
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA OD8EG
UT WOS:000580079400001
PM 32825327
OA Green Published, gold
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Yan, Y
   Wang, SQ
   Gu, JP
   Min, ZH
   Wang, RZ
AF Yan, Yan
   Wang, Shiqing
   Gu, Jinping
   Min, Zhihong
   Wang, Ruizhi
TI Effect of Nano-Oleanolic Acid Combined With Lipid-Lowering Ketones on
   Insulin Resistance in Rats with Gestational Diabetes
SO JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
LA English
DT Article
DE T2DM; Nano-Oleanolic Acid; Lipid-Lowering Ketone; Insulin Resistance
AB Diabetes is a widespread metabolic syndrome, an important complication during pregnancy. Most cases are type 2 diabetes, which has attracted the attention of the World Health Organization. The typical feature of T2DM is insulin resistance (IR). Its mechanism remains unclear, but it mainly manifests through parameters like insulin sensitivity, blood glucose level, and liver stability. Oxidative stress and insulin transduction play an important role in IR. This study simulates the disease situation, establishes a high-fat and high-fructose-induced model induced by tert-butyl hydroperoxide (tBHP), and adopts nano-sized oleanolic acid combined with lipid-lowering ketones to explore improvement in the IR mechanism. We found combining nano-sized oleanolic acid and lipid-lowering ketones can slow down the weight gain process in rats, reduce fasting blood glucose levels,increase the insulin sensitivity index, reduce the serum MDA, NO, and triglyceride IP: 18275 48 10 On Mon 02 May 2022 14:30 50 content, and increase SOD, CAT activity.In summary, our results show that the combined use of nano-sized oleanolic Copyright: American Scientific Pub shers acid and lipid-lowering ketone in pregnant rats with double height can reduce glucose metabolism, delay lipid production, Delivered by Ingenta and reduce oxidative stress, which is useful for further treatment and interpretation of T2DM The mechanism provides a theoretical basis.
C1 [Yan, Yan; Gu, Jinping; Min, Zhihong] Tongji Univ, Shanghai Matern & Infant Hosp 1, Shanghai Key Lab Maternal Fetal Med, Dept Obstet,Sch Med, Shanghai 200092, Peoples R China.
   [Wang, Shiqing; Wang, Ruizhi] Fudan Univ, Huadong Hosp, Dept Radiol, Shanghai 200040, Peoples R China.
C3 Tongji University; Fudan University
RP Yan, Y (corresponding author), Tongji Univ, Shanghai Matern & Infant Hosp 1, Shanghai Key Lab Maternal Fetal Med, Dept Obstet,Sch Med, Shanghai 200092, Peoples R China.; Wang, RZ (corresponding author), Fudan Univ, Huadong Hosp, Dept Radiol, Shanghai 200040, Peoples R China.
EM wang_editor2013@163.com; wangruizhi.doc@163.com
OI GU, JIN PING/0009-0002-6143-8957
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NR 22
TC 4
Z9 4
U1 0
U2 9
PU AMER SCIENTIFIC PUBLISHERS
PI VALENCIA
PA 26650 THE OLD RD, STE 208, VALENCIA, CA 91381-0751 USA
SN 1550-7033
EI 1550-7041
J9 J BIOMED NANOTECHNOL
JI J. Biomed. Nanotechnol.
PD FEB
PY 2022
VL 18
IS 2
BP 474
EP 480
DI 10.1166/jbn.2022.3262
PG 7
WC Nanoscience & Nanotechnology; Materials Science, Biomaterials
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics; Materials Science
GA 1F9AD
UT WOS:000795451600002
PM 35484734
DA 2025-06-11
ER

PT J
AU Devi, A
   Dwibedi, V
   Khan, ZA
AF Devi, Arti
   Dwibedi, Vagish
   Khan, Zaved Ahmed
TI Natural Antioxidants in New Age-Related Diseases
SO REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY
LA English
DT Review
DE Mitochondrial dysfunction; Oxidative stress; Phytochemicals; Reactive
   oxygen species; Anti-inflammatory
ID OXIDATIVE STRESS; ALZHEIMERS-DISEASE; L-CARNITINE; IN-VITRO; ACID;
   CURCUMINOIDS; PREVENTION; THERAPY; INJURY; RATS
AB The high prevalence of age-related diseases among the population explosion of senior citizens has gained significance in the pursuit of therapeutic agents capable of slowing the progression of degenerative disorders and preventing premature aging. Since our societies' rising longevity is correlated with an increase in morbidity, preserving health in old age has become the main objective for biomedicine. Natural antioxidants are increasingly used as healthy ingredients in the nutrition, cosmetics, and pharmaceutical industries. Some synthetic drugs used as health supplements are enzyme inhibitors mediating several disease processes. However, due to concerns regarding their toxicity and adverse effects, several newly discovered heterogeneous phenolic and biphenolic structures have sparked a search for novel, safe, and effective agents, especially from natural sources. Natural antioxidants are one of the most well-studied natural product groups due to the wide range of biological effects they have. This review summarizes current knowledge on the various antioxidants and their action against age-related diseases like rheumatoid arthritis, skin aging, eye degeneration, metabolic syndrome, and neuroinflammation. According to our study, a wide variety of antioxidants have been examined, and although some potential therapeutic molecules have been identified based on their antioxidant action, further in vivo studies and evaluation are needed before a possible therapeutic implementation as drug candidates.
C1 [Devi, Arti; Dwibedi, Vagish] Chandigarh Univ, Univ Inst Biotechnol, Mohali, Punjab, India.
   [Khan, Zaved Ahmed] Chandigarh Univ, Univ Inst Biotechnol, Dept Biotechnol Engn, Mohali, Punjab, India.
C3 Chandigarh University; Chandigarh University
RP Khan, ZA (corresponding author), Chandigarh Univ, Univ Inst Biotechnol, Dept Biotechnol Engn, Mohali, Punjab, India.
EM hod.uie.biotech@cumail.in
RI Dwibedi, Vagish/AAP-6419-2021
OI Devi, Arti/0000-0003-4878-4919; DWIBEDI, VAGISH/0000-0002-5288-7788;
   Khan, Zaved Ahmed/0000-0003-1984-0774
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NR 100
TC 27
Z9 30
U1 1
U2 12
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0102-695X
EI 1981-528X
J9 REV BRAS FARMACOGN
JI Rev. Bras. Farmacogn.-Braz. J. Pharmacogn.
PD AUG
PY 2021
VL 31
IS 4
BP 387
EP 407
DI 10.1007/s43450-021-00175-0
EA SEP 2021
PG 21
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA WN0IP
UT WOS:000698866800001
DA 2025-06-11
ER

PT J
AU Tadros, FJ
   Andrade, JM
AF Tadros, Farah J.
   Andrade, Jeanette Mary
TI Impact of hesperidin in 100% orange juice on chronic disease biomarkers:
   A narrative systematic review and gap analysis
SO CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
LA English
DT Review
DE Adults; hesperidin; non-communicable diseases and chronic conditions;
   orange juice
ID ENDOTHELIAL FUNCTION; LIPID-PEROXIDATION; ANTIOXIDANT STATUS; METABOLIC
   SYNDROME; OXIDATIVE STRESS; CONTROLLED-TRIAL; DOUBLE-BLIND; CONSUMPTION;
   HUMANS; BIOAVAILABILITY
AB Hesperidin in orange juice may affect chronic disease biomarkers. This narrative systematic review aimed to determine appropriate recommendations toward the dose and frequency of hesperidin consumption from 100% orange juice and conduct a gap analysis. The Preferred Reporting Items for Systematic Review and Meta-analysis was conducted to identify articles through September 2020, utilizing four databases: Pub-Med Central, Agricola, Embase, and MEDLINE. Twenty articles met the inclusion criteria. Results showed that overall effect sizes from the studies were considerably weak. Although higher frequencies, doses, and concentration of hesperidin in 100% orange juice had an impact on global cognitive function, cardiac, insulin, inflammatory, antioxidant/phenolic, and oxidative stress outcomes compared to lower frequencies, doses, and concentration of hesperidin. global cognitive function improved in 1 out of 2 studies over the intervention period. A gap analysis demonstrated there was a variability in dose and frequency of OJ and hesperidin, diet, genetics, and evaluation measures, which made the role of hesperidin in 100% OJ on chronic diseases unclear. This review revealed a trend toward improving chronic disease biomarkers following consumption of hesperidin in 100% orange juice. Steps can be taken in future research to improve the consistency of clinical study designs, methodology and outcomes.
C1 [Tadros, Farah J.; Andrade, Jeanette Mary] Univ Florida, Food Sci & Human Nutr Dept, 572 Newell Dr, Gainesville, FL 32611 USA.
C3 State University System of Florida; University of Florida
RP Andrade, JM (corresponding author), Univ Florida, Food Sci & Human Nutr Dept, 572 Newell Dr, Gainesville, FL 32611 USA.
EM jandrade1@ufl.edu
RI Andrade, Jeanette/V-5611-2019
OI Andrade, Jeanette/0000-0003-4452-4546; Tadros, Farah/0000-0002-1277-683X
FU Florida Department of Citrus, an executive agency of the state of
   Florida, USA [19-02]
FX This work was supported by the Florida Department of Citrus, an
   executive agency of the state of Florida, USA, under grant [#19-02]
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U2 22
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1040-8398
EI 1549-7852
J9 CRIT REV FOOD SCI
JI Crit. Rev. Food Sci. Nutr.
PD NOV 7
PY 2022
VL 62
IS 30
BP 8335
EP 8354
DI 10.1080/10408398.2021.1927976
EA MAY 2021
PG 20
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA 5X8MC
UT WOS:000652399100001
PM 34014143
OA Green Submitted, hybrid
DA 2025-06-11
ER

PT J
AU Britton, LJ
   Subramaniam, VN
   Crawford, DHG
AF Britton, Laurence J.
   Subramaniam, V. Nathan
   Crawford, Darrell H. G.
TI Iron and non-alcoholic fatty liver disease
SO WORLD JOURNAL OF GASTROENTEROLOGY
LA English
DT Review
DE Iron; Fatty liver; Liver steatosis; Insulin resistance; Steatohepatitis;
   Diabetes mellitus; Adipose tissue
ID ENDOPLASMIC-RETICULUM STRESS; GESTATIONAL DIABETES-MELLITUS;
   ADIPOSE-TISSUE INFLAMMATION; SERUM FERRITIN LEVELS; HEART-STUDY COHORT;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; HEPATIC IRON; METABOLIC SYNDROME;
   HEREDITARY HEMOCHROMATOSIS
AB The mechanisms that promote liver injury in non-alcoholic fatty liver disease (NAFLD) are yet to be thoroughly elucidated. As such, effective treatment strategies are lacking and novel therapeutic targets are required. Iron has been widely implicated in the pathogenesis of NAFLD and represents a potential target for treatment. Relationships between serum ferritin concentration and NAFLD are noted in a majority of studies, although serum ferritin is an imprecise measure of iron loading. Numerous mechanisms for a pathogenic role of hepatic iron in NAFLD have been demonstrated in animal and cell culture models. However, the human data linking hepatic iron to liver injury in NAFLD is less clear, with seemingly conflicting evidence, supporting either an effect of iron in hepatocytes or within reticulo-endothelial cells. Adipose tissue has emerged as a key site at which iron may have a pathogenic role in NAFLD. Evidence for this comes indirectly from studies that have evaluated the role of adipose tissue iron with respect to insulin resistance. Adding further complexity, multiple strands of evidence support an effect of NAFLD itself on iron metabolism. In this review, we summarise the human and basic science data that has evaluated the role of iron in NAFLD pathogenesis.
C1 [Britton, Laurence J.; Crawford, Darrell H. G.] Univ Queensland, Gallipoli Med Res Inst, Greenslopes Private Hosp, Newdegate St, Brisbane, Qld 4120, Australia.
   [Britton, Laurence J.] Princess Alexandra Hosp, Brisbane, Qld 4120, Australia.
   [Subramaniam, V. Nathan] QIMR Berghofer Med Res Inst, Brisbane, Qld 4120, Australia.
C3 Greenslopes Private Hospital; University of Queensland; Princess
   Alexandra Hospital; QIMR Berghofer Medical Research Institute
RP Britton, LJ (corresponding author), Univ Queensland, Gallipoli Med Res Inst, Greenslopes Private Hosp, Newdegate St, Brisbane, Qld 4120, Australia.
EM l.britton@uq.edu.au
RI Crawford, Darrell/F-2157-2010; Britton, Laurence/M-1355-2013;
   Subramaniam, V. Nathan/A-1901-2010
OI Crawford, Darrell/0000-0001-8480-5954; Subramaniam, V.
   Nathan/0000-0002-4583-7790; Britton, Laurence/0000-0003-1687-9366
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NR 105
TC 102
Z9 108
U1 0
U2 28
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 8226 REGENCY DR, PLEASANTON, CA 94588 USA
SN 1007-9327
EI 2219-2840
J9 WORLD J GASTROENTERO
JI World J. Gastroenterol.
PD SEP 28
PY 2016
VL 22
IS 36
BP 8112
EP 8122
DI 10.3748/wjg.v22.i36.8112
PG 11
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA DW9LY
UT WOS:000383982700006
PM 27688653
OA hybrid, Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Olivier-Van Stichelen, S
   Hanover, JA
AF Olivier-Van Stichelen, Stephanie
   Hanover, John A.
TI You are what you eat: O-linked N-acetylglucosamine in disease,
   development and epigenetics
SO CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE
LA English
DT Review
DE development; epigenetics; intrauterine environment; metabolic syndrome;
   O-linked N-acetylglucosamine
ID GLCNAC TRANSFERASE OGT; EMBRYONIC STEM-CELLS; GENE-EXPRESSION;
   X-INACTIVATION; DIABETIC COMPLICATIONS; GLCNACYLATION; DIFFERENTIATION;
   METABOLISM; CHROMATIN; STRESS
AB Purpose of review
   The O-linked N-acetylglucosamine (O-GlcNAc) modification is both responsive to nutrient availability and capable of altering intracellular cellular signalling. We summarize data defining a role for O-GlcNAcylation in metabolic homeostasis and epigenetic regulation of development in the intrauterine environment.
   Recent findings
   O-GlcNAc transferase (OGT) catalyzes nutrient-driven O-GlcNAc addition and is subject to random X-inactivation. OGT plays key roles in growth factor signalling, stem cell biology, epigenetics and possibly imprinting. The O-GlcNAcase, which removes O-GlcNAc, is subject to tight regulation by higher order chromatin structure. O-GlcNAc cycling plays an important role in the intrauterine environment wherein OGT expression is an important biomarker of placental stress.
   Summary
   Regulation of O-GlcNAc cycling by X-inactivation, epigenetic regulation and nutrient-driven processes makes it an ideal candidate for a nutrient-dependent epigenetic regulator of human disease. In addition, O-GlcNAc cycling influences chromatin modifiers critical to the regulation and timing of normal development including the polycomb repression complex and the ten-eleven translocation proteins mediating DNA methyl cytosine demethylation. The pathway also impacts the hypothalamic-pituitary-adrenal axis critical to intrauterine programming influencing disease susceptibility in later life.
C1 [Olivier-Van Stichelen, Stephanie; Hanover, John A.] NIDDK, NIH, Bethesda, MD USA.
C3 National Institutes of Health (NIH) - USA; NIH National Institute of
   Diabetes & Digestive & Kidney Diseases (NIDDK)
RP Hanover, JA (corresponding author), NIDDK, NIH, Bethesda, MD USA.
EM jah@helix.nih.gov
RI Olivier-Van Stichelen, Stephanie/AAH-9328-2021
OI Olivier-Van Stichelen, Stephanie/0000-0002-2033-5241
FU Intramural Program of the National Institutes of Diabetes, Digestive and
   Kidney Diseases (NIDDK), National Institutes of Health; Rotary
   Foundation Ambassadorial Scholarship from the Rotary Foundation
FX This work was supported by the Intramural Program of the National
   Institutes of Diabetes, Digestive and Kidney Diseases (NIDDK), National
   Institutes of Health. Dr Stephanie Olivier-Van Stichelen received
   support from the Rotary Foundation Ambassadorial Scholarship from the
   Rotary Foundation.
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NR 53
TC 40
Z9 48
U1 0
U2 20
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1363-1950
EI 1473-6519
J9 CURR OPIN CLIN NUTR
JI Curr. Opin. Clin. Nutr. Metab. Care
PD JUL
PY 2015
VL 18
IS 4
BP 339
EP 345
DI 10.1097/MCO.0000000000000188
PG 7
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA DD0QX
UT WOS:000369625600005
PM 26049631
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Chung, KF
   Adcock, IM
AF Chung, K. F.
   Adcock, I. M.
TI Multifaceted mechanisms in COPD: inflammation, immunity, and tissue
   repair and destruction
SO EUROPEAN RESPIRATORY JOURNAL
LA English
DT Review
DE autoimmunity; chronic obstructive pulmonary disease; macrophages;
   neutrophil; oxidative stress; senescence
ID OBSTRUCTIVE PULMONARY-DISEASE; AIRWAY SMOOTH-MUSCLE; NF-KAPPA-B;
   TUMOR-NECROSIS-FACTOR; SMOKE-INDUCED EMPHYSEMA; GROWTH-FACTOR RECEPTOR;
   NONTYPABLE HAEMOPHILUS-INFLUENZAE; PROINFLAMMATORY CYTOKINE RELEASE;
   ENHANCED BRONCHIAL EXPRESSION; BRONCHOALVEOLAR LAVAGE FLUID
AB Chronic obstructive pulmonary disease is a leading global cause of morbidity and mortality that is characterised by inexorable deterioration of small airways obstruction with emphysema associated with cellular inflammation and structural remodelling. Other features include apoptosis as well as proliferation of cells, and both tissue repair and lack of tissue repair.
   Metalloprotease release, together with that of apoptotic factors, may underlie the emphysema, and, conversely, fibrosis of the small airways may be accounted for by the effects of growth factor activation. In advanced disease, influential factors include the development of autoimmunity, with activation of dendritic cells and T-helper cells of both type 1 and 2, and the senescence response.
   An inability of macrophages to ingest apoptosed cells and bacteria may exacerbate inflammatory responses. Systemic inflammation with concomitant cardiovascular disease and metabolic syndrome may reflect the effect of cigarette smoke on nonpulmonary cells. Corticosteroid resistance may be secondary to oxidative stress mechanisms, such as inactivation of histone deacetylases.
   The mechanisms of chronic obstructive pulmonary disease may be heterogeneous, according to severity, and clinical phenotypes need to be correlated with cellular and pathological processes. Treatments may be targeted to patients with specific mechanisms.
C1 [Chung, K. F.] Imperial Coll London, Natl Heart & Lung Inst, Sect Airways Dis, London SW3 6LY, England.
C3 Imperial College London
RP Chung, KF (corresponding author), Imperial Coll London, Natl Heart & Lung Inst, Sect Airways Dis, Dovehouse St, London SW3 6LY, England.
EM f.chung@imperial.ac.uk
RI Adcock, Ian/L-3217-2019; Chung, Kian Fan/B-1872-2012
OI Adcock, Ian/0000-0003-2101-8843; Chung, Kian Fan/0000-0001-7101-1426
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NR 295
TC 462
Z9 507
U1 1
U2 96
PU EUROPEAN RESPIRATORY SOC JOURNALS LTD
PI SHEFFIELD
PA 442 GLOSSOP RD, SHEFFIELD S10 2PX, ENGLAND
SN 0903-1936
EI 1399-3003
J9 EUR RESPIR J
JI Eur. Resp. J.
PD JUN
PY 2008
VL 31
IS 6
BP 1334
EP 1356
DI 10.1183/09031936.00018908
PG 23
WC Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Respiratory System
GA 312XM
UT WOS:000256705700029
PM 18515558
OA Bronze
DA 2025-06-11
ER

PT J
AU Danciu, SC
   Krause, SW
   Wagner, C
   Gonzalez, J
   Brenchley, J
   Clark, C
   Herrera, CJ
AF Danciu, Sorin C.
   Krause, Steven W.
   Wagner, Chris
   Gonzalez, Joaquin
   Brenchley, Jackie
   Clark, Clifton
   Herrera, Cesar J.
TI VO2 max and anaerobic threshold in hypertension:: A tissue
   Doppler study
SO ECHOCARDIOGRAPHY-A JOURNAL OF CARDIOVASCULAR ULTRASOUND AND ALLIED
   TECHNIQUES
LA English
DT Article
DE tissue Doppler imaging; hypertension; VO2 Max; anaerobic threshold
ID LEFT-VENTRICULAR HYPERTROPHY; DIASTOLIC FUNCTION; EXERCISE CAPACITY;
   ECHOCARDIOGRAPHY; VELOCITY; INDEXES; IMPACT; PERFORMANCE; PATTERNS;
   INSIGHTS
AB Background: Hypertension can impair left ventricular (LV) relaxation causing shortness of breath and reduced exercise capacity, which may affect the clinical evaluation of the symptomatic hypertensive patient. In this study we used tissue Doppler imaging (TDI) to identify correlates of anaerobic threshold (AT) and maximum oxygen uptake (VO2 Max). Our goal was to assess the feasibility of TDI as a surrogate of functional capacity in hypertensive individuals. Methods: We studied subjects without metabolic syndrome and with normal LV function (ejection fraction (EF) > 50%). Traditional echocardiographic variables were obtained before and after a cardiopulmonary exercise test. Systolic (S) and diastolic (E' and A') myocardial velocities were measured at the basal septal (bs) and posterior (bp) walls. Results: After multivariate analysis, resting E'bp (r = 0.56, P < 0.002) and isovolumic relaxation time (IVRT) (r = -0.49, I < 0.03) correlated with VO2 Max, while A Valsalva correlated with AT (r = -0.46, P < 0.03). Peak stress E'/A' bp correlated with age and gender corrected METs (r = -0.63, P < 0.0004) and VO2 Max (r = -0.39, P < 0.04). Conclusions: Resting E'bp and peak stress E'/A' bp correlate with VO2 Max in hypertensive patients. TDI may be an important tool when assessing symptoms in this population.
C1 [Danciu, Sorin C.; Krause, Steven W.; Wagner, Chris; Gonzalez, Joaquin; Herrera, Cesar J.] Advocate Illinois Masonic Med Ctr, Dept Internal Med, Cardiol Sect, Chicago, IL 60657 USA.
   [Brenchley, Jackie; Clark, Clifton] Advocate Illinois Masonic Med Ctr, Sect Pulm Med, Chicago, IL 60657 USA.
RP Danciu, SC (corresponding author), Advocate Illinois Masonic Med Ctr, Dept Internal Med, Cardiol Sect, 836 W Wellington Ave,Cardiol Adm Room 1247, Chicago, IL 60657 USA.
EM sorin.danciu-md@advocatehealth.com
RI Herrera R, César/ISV-2438-2023
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NR 24
TC 10
Z9 11
U1 1
U2 21
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0742-2822
EI 1540-8175
J9 ECHOCARDIOGR-J CARD
JI Echocardiography-J. Cardiovasc. Ultrasound Allied Tech.
PD FEB
PY 2008
VL 25
IS 2
BP 156
EP 161
DI 10.1111/j.1540-8175.2007.00577.x
PG 6
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 258VL
UT WOS:000252897500006
PM 18269560
DA 2025-06-11
ER

PT J
AU Jo, SL
   Yang, H
   Lee, SR
   Heo, JH
   Lee, HW
   Hong, EJ
AF Jo, Seong-Lae
   Yang, Hyun
   Lee, Sang R.
   Heo, Jun H.
   Lee, Hye-Won
   Hong, Eui-Ju
TI Curcumae Radix Decreases Neurodegenerative Markers through Glycolysis
   Decrease and TCA Cycle Activation
SO NUTRIENTS
LA English
DT Article
DE Curcumae radix; Alzheimer's disease; neurodegenerative disease;
   glycolysis; TCA cycle
ID ENDOPLASMIC-RETICULUM STRESS; PENTOSE-PHOSPHATE PATHWAY;
   GENE-EXPRESSION; TRANSGENIC MICE; HUMAN BRAIN; APOPTOSIS;
   OVEREXPRESSION; MITOCHONDRIA; METABOLISM; GENERATION
AB Neurodegenerative diseases (ND) are being increasingly studied owing to the increasing proportion of the aging population. Several potential compounds are examined to prevent neurodegenerative diseases, including Curcumae radix, which is known to be beneficial for inflammatory conditions, metabolic syndrome, and various types of pain. However, it is not well studied, and its influence on energy metabolism in ND is unclear. We focused on the relationship between ND and energy metabolism using Curcumae radix extract (CRE) in cells and animal models. We monitored neurodegenerative markers and metabolic indicators using Western blotting and qRT-PCR and then assessed cellular glycolysis and metabolic flux assays. The levels of Alzheimer's disease-related markers in mouse brains were reduced after treatment with the CRE. We confirmed that neurodegenerative markers decreased in the cerebrum and brain tumor cells following low endoplasmic reticulum (ER) stress markers. Furthermore, glycolysis related genes and the extracellular acidification rate decreased after treatment with the CRE. Interestingly, we found that the CRE exposed mouse brain and cells had increased mitochondrial Tricarboxylic acid (TCA) cycle and Oxidative phosphorylation (OXPHOS) related genes in the CRE group. Curcumae radix may act as a metabolic modulator of brain health and help treat and prevent ND involving mitochondrial dysfunction.
C1 [Jo, Seong-Lae; Lee, Sang R.; Heo, Jun H.; Hong, Eui-Ju] Chungnam Natl Univ, Coll Vet Med, Daejeon 34134, South Korea.
   [Yang, Hyun; Lee, Hye-Won] Korea Inst Oriental Med, KM Convergence Res Div, Daejeon 34054, South Korea.
C3 Chungnam National University; Korea Institute of Oriental Medicine
   (KIOM)
RP Hong, EJ (corresponding author), Chungnam Natl Univ, Coll Vet Med, Daejeon 34134, South Korea.; Lee, HW (corresponding author), Korea Inst Oriental Med, KM Convergence Res Div, Daejeon 34054, South Korea.
EM jsr7093@nate.com; hyunyang@kiom.re.kr; srlee5@naver.com;
   heojh0624@naver.com; anywon1975@gmail.com; ejhong@cnu.ac.kr
RI ; Lee, Hye Won/D-9081-2016
OI Hong, Eui-Ju/0000-0001-9640-8841; Lee, Sangryeol/0000-0002-5809-9854;
   Lee, Hye Won/0000-0003-4248-1482
FU Basic Science Research Program through the National Research Foundation
   of Korea (NRF) - Ministry of Education [2021R1I1A2042991]; National
   Research Foundation of Korea (NRF) - Korean government (MSIT)
   [2021R1C1C1010484]
FX This research was supported by the Basic Science Research Program
   through the National Research Foundation of Korea (NRF), funded by the
   Ministry of Education (2021R1I1A2042991). This work was supported by the
   National Research Foundation of Korea (NRF) grant funded by the Korean
   government (MSIT) (2021R1C1C1010484).
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Z9 14
U1 2
U2 19
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD APR
PY 2022
VL 14
IS 8
AR 1587
DI 10.3390/nu14081587
PG 15
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 0R2OR
UT WOS:000785441700001
PM 35458149
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Chen, XC
   Zhao, C
   Xu, YT
   Huang, KL
   Wang, YL
   Wang, XY
   Zhou, XG
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   Yang, GS
   Yu, TY
AF Chen, Xiaochang
   Zhao, Chen
   Xu, Yanting
   Huang, Kuilong
   Wang, Yulong
   Wang, Xiaoyu
   Zhou, Xiaoge
   Pang, Weijun
   Yang, Gongshe
   Yu, Taiyong
TI Adipose-specific BMP and activin membrane-bound inhibitor (BAMBI)
   deletion promotes adipogenesis by accelerating ROS production
SO JOURNAL OF BIOLOGICAL CHEMISTRY
LA English
DT Article
ID ADIPOCYTE DIFFERENTIATION; STEM-CELL; BETA; OBESITY; INSIGHTS; STRESS
AB With the improvement of people's living standards, the number of obese patients has also grown rapidly. It is reported that the level of oxidative stress in obese patients has significantly increased, mainly caused by the increase in reactive oxygen species (ROS) levels in adipose tissue. Studies have shown that the use of siRNA to interfere with bone morphogenetic protein and activin membrane-bound inhibitor (BAMBI) expression could promote adipocyte differentiation, and under hypoxic conditions, BAMBI could act as a regulator of HIF1a to regulate the polarity damage of epithelial cells. In view of these results, we speculated that BAMBI may regulate adipogenesis by regulating the level of ROS. In this study, we generated adipose-specific BAMBI knockout mice (BAMBI AKO) and found that compared with control mice, BAMBI AKO mice showed obesity when fed with high-fat diet, accompanied by insulin resistance, glucose intolerance, hypercholesterolemia, and increased inflammation in adipose tissue. Interestingly, adipose-specific deficiency of BAMBI could cause an increase in the expression level of Nox4, thereby promoting ROS production in cytoplasm and mitochondria and the DNA-binding activity of C/EBP beta and ultimately promoting adipogenesis. Consistently, our findings indicated that BAMBI may be a reactive oxygen regulator to affect adipogenesis, thereby controlling obesity and metabolic syndrome.
C1 [Chen, Xiaochang; Zhao, Chen; Xu, Yanting; Huang, Kuilong; Wang, Yulong; Wang, Xiaoyu; Zhou, Xiaoge; Pang, Weijun; Yang, Gongshe; Yu, Taiyong] Northwest A&F Univ, Coll Anim Sci & Technol, Key Lab Anim Genet Breeding & Reprod Shaanxi Prov, Lab Anim Fat Deposit & Muscle Dev, Yangling, Shaanxi, Peoples R China.
C3 Northwest A&F University - China
RP Yu, TY (corresponding author), Northwest A&F Univ, Coll Anim Sci & Technol, Key Lab Anim Genet Breeding & Reprod Shaanxi Prov, Lab Anim Fat Deposit & Muscle Dev, Yangling, Shaanxi, Peoples R China.
EM yutaiyong310@nwsuaf.edu.cn
OI Yu, Taiyong/0000-0001-6951-9968; Wang, Yulong/0009-0002-0055-388X; Wang,
   Xiaoyu/0000-0002-0861-0204
FU Key R&D Program of Shaanxi [2018ZDCXL-NY-02-05]; National Science and
   Technology Major Project of China [2016ZX08006003]; National Key R&D
   Program of China [2017YFD0502003]
FX This work was supported by Key R&D Program of Shaanxi (2017ZDXM-NY-077),
   National Science and Technology Major Project of China (2016ZX08006003),
   Key R&D Program of Shaanxi (2018ZDCXL-NY-02-05), and National Key R&D
   Program of China (2017YFD0502003).
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NR 35
TC 20
Z9 23
U1 1
U2 12
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
EI 1083-351X
J9 J BIOL CHEM
JI J. Biol. Chem.
PD JAN-JUN
PY 2021
VL 296
AR 100037
DI 10.1074/jbc.RA120.014793
PG 13
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA TI5TQ
UT WOS:000672866400021
PM 33158991
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Salekzamani, S
   Ebrahimi-Mameghani, M
   Rezazadeh, K
AF Salekzamani, Shabnam
   Ebrahimi-Mameghani, Mehrangiz
   Rezazadeh, Khatereh
TI The antioxidant activity of artichoke (Cynara scolymus): A
   systematic review and meta-analysis of animal studies
SO PHYTOTHERAPY RESEARCH
LA English
DT Review
DE antioxidant; artichoke; Cynara scolymus; oxidative stress; reactive
   oxygen species
ID INDUCED OXIDATIVE STRESS; LEAF EXTRACT SUPPLEMENTATION; IN-VITRO;
   FREE-RADICALS; PROTECTIVE PROPERTIES; METABOLIC SYNDROME; L. EXTRACT;
   POLYPHENOLS; HEADS; LIPOPROTEIN
AB Current evidence has shown antioxidant activity of artichoke as a potent source of antioxidant compounds. However, it seems that the antioxidant activity of artichoke has not yet been reviewed. Therefore, the present study was designed to perform a systematic review of human studies, animal models, and in vitro systems and to conduct a meta-analysis of animal studies on the antioxidant effects of artichoke. We searched four electronic databases till April 2018 using relevant keywords. All English language articles were assessed. For animal studies, standardized mean difference was pooled using a random effects model. The included studies were evaluated for eligibility and risk of bias. Thirty-nine articles (two human, 23 animal, and 14 in vitro studies) were reviewed. The results of in vitro systems supported the antioxidant effect of artichoke, whereas limited clinical trials indicated no change or a slight improvement of antioxidant status. Finding of animal studies indicated that artichoke extract supplementation increased superoxide dismutase, catalase, glutathione, and glutathione peroxidase level in liver, as well as, decreased malondialdehyde level in liver and plasma of animals with induced disease significantly compared with comparison group. This meta-analysis provided convincing evidence for antioxidant activity of artichoke in animals.
C1 [Salekzamani, Shabnam; Ebrahimi-Mameghani, Mehrangiz; Rezazadeh, Khatereh] Tabriz Univ Med Sci, Sch Nutr & Food Sci, Nutr Res Ctr, Attar Neyshaboori Av,Golghasht St, Tabriz, Iran.
C3 Tabriz University of Medical Science
RP Rezazadeh, K (corresponding author), Tabriz Univ Med Sci, Sch Nutr & Food Sci, Nutr Res Ctr, Attar Neyshaboori Av,Golghasht St, Tabriz, Iran.
EM rezazadekhatere@gmail.com
RI Salekzamani, Shabnam/AHD-8916-2022; Rezazadeh, Khatereh/N-2488-2019;
   Ebrahimi-Mameghani, Mehrangiz/G-6461-2017
OI Ebrahimi-Mameghani, Mehrangiz/0000-0002-0311-1289; rezazadeh,
   khatereh/0000-0002-9270-7788; Salekzamani, Shabnam/0000-0002-1303-8935
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NR 78
TC 49
Z9 51
U1 1
U2 50
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0951-418X
EI 1099-1573
J9 PHYTOTHER RES
JI Phytother. Res.
PD JAN
PY 2019
VL 33
IS 1
BP 55
EP 71
DI 10.1002/ptr.6213
PG 17
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA HG6AS
UT WOS:000455064000004
PM 30345589
DA 2025-06-11
ER

PT J
AU de Figueiredo, ASP
   Salmon, AB
   Bruno, F
   Jimenez, F
   Martinez, HG
   Halade, GV
   Ahuja, SS
   Clark, RA
   DeFronzo, RA
   Abboud, HE
   El Jamali, A
AF de Figueiredo, Alvaro Souto Padron
   Salmon, Adam B.
   Bruno, Francesca
   Jimenez, Fabio
   Martinez, Herman G.
   Halade, Ganesh V.
   Ahuja, Seema S.
   Clark, Robert A.
   DeFronzo, Ralph A.
   Abboud, Hanna E.
   El Jamali, Amina
TI Nox2 Mediates Skeletal Muscle Insulin Resistance Induced by a High Fat
   Diet
SO JOURNAL OF BIOLOGICAL CHEMISTRY
LA English
DT Article
ID NADPH OXIDASE ACTIVITY; ELECTRON-TRANSPORT; DIABETES-MELLITUS; OXIDATIVE
   STRESS; PLASMA-MEMBRANE; NAD(P)H OXIDASE; L6 MYOTUBES; GLUCOSE; GLUT4;
   DYSFUNCTION
AB Inflammation and oxidative stress through the production of reactive oxygen species (ROS) are consistently associated with metabolic syndrome/type 2 diabetes. Although the role of Nox2, a major ROS-generating enzyme, is well described in host defense and inflammation, little is known about its potential role in insulin resistance in skeletal muscle. Insulin resistance induced by a high fat diet was mitigated in Nox2-null mice compared with wild-type mice after 3 or 9 months on the diet. High fat feeding increased Nox2 expression, superoxide production, and impaired insulin signaling in skeletal muscle tissue of wild-type mice but not in Nox2-null mice. Exposure of C2C12 cultured myotubes to either high glucose concentration, palmitate, or H2O2 decreases insulin-induced Akt phosphorylation and glucose uptake. Pretreatment with catalase abrogated these effects, indicating a key role for H2O2 in mediating insulin resistance. Down-regulation of Nox2 in C2C12 cells by shRNA prevented insulin resistance induced by high glucose or palmitate but not H2O2. These data indicate that increased production of ROS in insulin resistance induced by high glucose in skeletal muscle cells is a consequence of Nox2 activation. This is the first report to show that Nox2 is a key mediator of insulin resistance in skeletal muscle.
C1 [de Figueiredo, Alvaro Souto Padron; Bruno, Francesca; Jimenez, Fabio; Martinez, Herman G.; Halade, Ganesh V.; Ahuja, Seema S.; Clark, Robert A.; DeFronzo, Ralph A.; Abboud, Hanna E.; El Jamali, Amina] Univ Texas Hlth Sci Ctr San Antonio, Dept Med, San Antonio, TX 78229 USA.
   [Salmon, Adam B.] Sam & Ann Barshop Inst Longev & Aging Studies, San Antonio, TX 78245 USA.
   [Salmon, Adam B.; Ahuja, Seema S.; Clark, Robert A.; DeFronzo, Ralph A.; Abboud, Hanna E.] South Texas Vet Hlth Care Syst, Audie L Murphy Hosp, San Antonio, TX 78229 USA.
C3 University of Texas System; University of Texas Health Science Center at
   San Antonio; US Department of Veterans Affairs; Veterans Health
   Administration (VHA); Audie L. Murphy Memorial Veterans Hospital
RP El Jamali, A (corresponding author), Univ Texas Hlth Sci Ctr San Antonio, Dept Med, 7703 Floyd Curl Dr, San Antonio, TX 78229 USA.
EM AkoulouzeBik@uthscsa.edu
RI Clark, Robert/Q-6764-2019
OI Clark, Robert/0000-0002-4892-3619
FU National Institutes of Health [P30 CA054174, P30 AG013319, P01 AG019316]
FX The confocal microscopy studies were performed in the Institutional
   Optical Imaging Facility of the University of Texas Health Science
   Center at San Antonio, which is supported by National Institutes of
   Health Grants P30 CA054174 (Cancer Therapy and Research Center), P30
   AG013319 (Nathan Shock Center), and P01 AG019316 (Aging, Oxidative
   Stress, and Cell Death). We thank Drs. Alain Virion for helpful
   discussions, Dr. John Cornell for insightful advice on statistical
   analysis, Dr. James Lechleiter for expert guidance on the confocal
   microscope image acquisition and analysis, and Yimin Wu, Maria Gamez,
   and Jacob Crandall for expert technical assistance.
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NR 48
TC 70
Z9 80
U1 0
U2 8
PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3996 USA
EI 1083-351X
J9 J BIOL CHEM
JI J. Biol. Chem.
PD MAY 22
PY 2015
VL 290
IS 21
BP 13427
EP 13439
DI 10.1074/jbc.M114.626077
PG 13
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA CI7WL
UT WOS:000354975700038
PM 25825489
OA Green Published
DA 2025-06-11
ER

PT J
AU Philouze, C
   Obert, P
   Nottin, S
   Benamor, A
   Barthez, O
   Aboukhoudir, F
AF Philouze, Clothilde
   Obert, Philippe
   Nottin, Stephane
   Benamor, Asma
   Barthez, Olivier
   Aboukhoudir, Falah
TI Dobutamine Stress Echocardiography Unmasks Early Left Ventricular
   Dysfunction in Asymptomatic Patients with Uncomplicated Type 2 Diabetes:
   A Comprehensive Two-Dimensional Speckle-Tracking Imaging Study
SO JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY
LA English
DT Article
DE Uncomplicated type 2 diabetes; Asymptomatic patients; Dobutamine stress
   echocardiography; Speckle-tracking imaging; Regional myocardial
   function; Epicardial adipose tissue
ID EPICARDIAL ADIPOSE-TISSUE; CORONARY-ARTERY-DISEASE; METABOLIC SYNDROME;
   FLOW RESERVE; STRAIN-RATE; MYOCARDIAL-FUNCTION; HEART-FAILURE; MELLITUS;
   MECHANICS; EXERCISE
AB Background: Discrepancies are present in the literature on resting myocardial mechanics in patients with uncomplicated type 2 diabetes mellitus (T2DM). Data are noticeably sparse regarding circumferential function and torsional mechanics. Resting deformation imaging may not be sensitive enough to detect subtle dysfunctions. The aim of this study was thus to comprehensively evaluate myocardial mechanics in patients with T2DM at rest and to investigate whether dobutamine stress echocardiography could unmask functional alterations that would remain otherwise subtle at rest.
   Methods: Forty-four patients with T2DM and 35 healthy control subjects of similar age and sex were prospectively recruited. After conventional echocardiography, myocardial mechanics was evaluated at rest and during low-dose dobutamine stress echocardiography (target heart rate, 110 beats/min).
   Results: Patients with T2DM presented with altered global diastolic function but preserved systolic function. Deformation imaging indexes were similar between groups at rest, but significant differences were noticed under dobutamine infusion for longitudinal strain (-21.2 +/- 2.4% vs -24.2 +/- 2.5%, P < .001), circumferential strain (apex, -32.3 +/- 5.3% vs -36.3 +/- 5.3%, P = .002; papillary muscle, -25.6 +/- 3.2% vs -28.0 +/- 3.6%, P = .001; base, -23.2 +/- 3.6% vs -25.3 +/- 3.8%, P = .03), apical (11.2 +/- 4.4 degrees vs 14.1 +/- 6.3 degrees, P = .020) and basal (-12.2 +/- 3.3 degrees vs -14.3 +/- 3.9 degrees, P = .021) rotation, and twist (21.9 +/- 5.9 degrees vs 26.8 +/- 8.3 degrees, P = .007). Multivariate analysis identified epicardial fat, dyslipidemia, and fasting glycaemia as significant contributors to the changes from rest to dobutamine.
   Conclusions: These findings demonstrate the usefulness of dobutamine stress echocardiography in establishing impairments in myocardial mechanics in patients with uncomplicated T2DM. Systemic metabolic disturbances and epicardial fat act as the main contributors to the blunted response to dobutamine stress in these patients.
C1 [Philouze, Clothilde; Obert, Philippe; Nottin, Stephane; Benamor, Asma; Aboukhoudir, Falah] Avignon Univ, Lab Cardiovasc Pharm Ecol, LaPEC EA4278, Avignon, France.
   [Barthez, Olivier; Aboukhoudir, Falah] Duffaut Hosp Ctr, Dept Cardiol, Avignon, France.
C3 Avignon Universite
RP Aboukhoudir, F (corresponding author), Univ Avignon, Fac Sci, 301 Rue Baruch Spinoza, F-84916 Avignon 9, France.
EM faboukhoudir@ch-avignon.fr
OI Philouze, Clothilde/0000-0002-0669-0263; Nottin,
   Stephane/0000-0001-7797-1137
FU French Society of Cardiology
FX This study was funded by a grant from the French Society of Cardiology.
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NR 49
TC 23
Z9 28
U1 0
U2 9
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0894-7317
J9 J AM SOC ECHOCARDIOG
JI J. Am. Soc. Echocardiogr.
PD MAY
PY 2018
VL 31
IS 5
BP 587
EP 597
DI 10.1016/j.echo.2017.12.006
PG 11
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA GF7SF
UT WOS:000432167800008
PM 29526563
DA 2025-06-11
ER

PT J
AU Lala, SV
   Sajatovic, M
AF Lala, Sonali V.
   Sajatovic, Martha
TI Medical and Psychiatric Comorbidities Among Elderly Individuals With
   Bipolar Disorder: A Literature Review
SO JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY
LA English
DT Review
DE bipolar disorder; elderly; geriatric; comorbidity; mania
ID OLDER-ADULTS; PREVALENCE; DEMENTIA; AGE; LITHIUM; HEALTH; RISK;
   SCHIZOPHRENIA; INPATIENTS; DISEASE
AB Introduction: The common comorbid conditions that accompany late-life bipolar disorder (BD) have not been well studied. This is a literature review on psychiatric and medical comorbidities among elderly individuals with BD. Methods: A focused literature review searched PubMed. Inclusion criteria were original research reports, in English, until June 2009, specifically focused on medical and psychiatric comorbidities in BD individuals over the age of 50. Results: A limited number of studies were identified. Most involved small samples (n < 100). Metabolic syndrome, respiratory and cardiovascular conditions, and endocrine abnormalities are common, with patients having an average of 3 to 4 medical comorbid conditions. Approximately 4.5% to 19% of elderly individuals with BD have dementia. Rates of psychiatric comorbidity appear lower than in younger BD populations, with the most common concurrent psychiatric illnesses being anxiety and substance use disorders. Rates of comorbid medical conditions appear similar to rates among geriatric patients without BD. Conclusions: Elderly individuals with BD are burdened by multiple concomitant medical disorders. In contrast to the elevated rates of medical comorbidity, rates of psychiatric comorbidity appear lower in elderly individuals with BD than in younger populations with BD. Greater awareness of concurrent medical conditions might help inform coordinated care that considers both mental and physical health among geriatric patients with BD.
C1 [Lala, Sonali V.; Sajatovic, Martha] Case Western Reserve Univ, Sch Med, Cleveland, OH USA.
   [Sajatovic, Martha] Case Western Reserve Univ, Dept Psychiat, Univ Hosp Case Med Ctr, Cleveland, OH 44106 USA.
   [Sajatovic, Martha] Case Western Reserve Univ, Dept Neurol, Univ Hosp Case Med Ctr, Cleveland, OH 44106 USA.
   [Sajatovic, Martha] Neurol Outcomes Ctr, Cleveland, OH USA.
C3 University System of Ohio; Case Western Reserve University; University
   System of Ohio; Case Western Reserve University; Case Western Reserve
   University Hospital; University System of Ohio; Case Western Reserve
   University; Case Western Reserve University Hospital
RP Sajatovic, M (corresponding author), Univ Hosp Cleveland, Dept Psychiat, 11100 Euclid Ave, Cleveland, OH 44106 USA.
EM martha.sajatovic@uhhs.com
RI Sajatovic, Martha/I-8001-2014
FU AstraZeneca; Pfizer; Merck; Ortho-McNeil Janssen
FX Martha Sajatovic received research grants from AstraZeneca, Pfizer,
   Merck, and Ortho-McNeil Janssen; is a consultant for Cognition Group and
   United BioSource Corporation (Bracket); and receives royalties from
   Springer Press, Johns Hopkins University Press, and Oxford Press.
CR Cassidy F, 2001, BIPOLAR DISORD, V3, P181, DOI 10.1034/j.1399-5618.2001.30403.x
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NR 27
TC 78
Z9 81
U1 0
U2 19
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0891-9887
J9 J GERIATR PSYCH NEUR
JI J. Geriatr. Psychiatry Neurol.
PD MAR
PY 2012
VL 25
IS 1
SI SI
BP 20
EP 25
DI 10.1177/0891988712436683
PG 6
WC Geriatrics & Gerontology; Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Neurosciences & Neurology; Psychiatry
GA 923NM
UT WOS:000302626000004
PM 22467842
DA 2025-06-11
ER

PT J
AU Ghoussaini, R
   Tamim, H
   Elbejjani, M
   Makki, M
   Nasreddine, L
   Ismaeel, H
   Nasrallah, MP
   Zgheib, NK
AF Ghoussaini, Racha
   Tamim, Hani
   Elbejjani, Martine
   Makki, Maha
   Nasreddine, Lara
   Ismaeel, Hussain
   Nasrallah, Mona P. P.
   Zgheib, Nathalie K. K.
TI C-peptide is a predictor of telomere shortening: A five-year
   longitudinal study
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Article
DE telomere length; C-peptide; aging; metabolic; insulin resistance;
   predictor; telomere shortening
ID GREATER BEIRUT AREA; OXIDATIVE STRESS; INSULIN-RESISTANCE; LENGTH;
   HYPERTENSION; ASSOCIATION; PREVALENCE; SENESCENCE; MARKER; SLEEP
AB AimRelative telomere length (RTL) predicts the development of many age-related diseases. Yet, few studies have evaluated their longitudinal effect on RTL. We investigated longitudinally the association between cardiometabolic risk factors and RTL. MethodsThis was a longitudinal study with a 5-year follow-up period, based on data collected in 2014 and 2019. Of 478 participants in 2014, 198 consented to be followed-up in 2019. The associations between RTL and risk factors were analyzed using t-test, ANOVA or simple linear regression as applicable. ResultsRTL was significantly shortened after 5 years (P<0.001). Older age (P=0.018) and gender (P=0.05) were significantly associated with shorter RTL at follow-up. Higher baseline C-peptide correlated with shorter RTL (P=0.04) and shortening of RTL (P=0.03) after 5 years. Multivariate linear regression including both age and gender revealed a significant trend for C-peptide and change in RTL after 5 years (P=0.04). Interestingly, there was a trend of shorter RTL at follow-up with diabetes, though the findings were not statistically significant. ConclusionsHigher C-peptide level contributes to telomere shortening over time, suggesting that metabolic dysregulation may play a role in early aging. Further understanding of this relationship and addressing high C-peptide levels can be important to prevent premature aging.
C1 [Ghoussaini, Racha] Amer Univ Beirut, Fac Med, Sch Med, Med Ctr, Beirut, Lebanon.
   [Tamim, Hani; Elbejjani, Martine; Makki, Maha] Amer Univ Beirut, Clin Res Inst, Fac Med, Med Ctr, Beirut, Lebanon.
   [Tamim, Hani; Elbejjani, Martine] Amer Univ Beirut, Fac Med, Dept Internal Med, Med Ctr, Beirut, Lebanon.
   [Tamim, Hani] Alfaisal Univ, Coll Med, Riyadh, Saudi Arabia.
   [Nasreddine, Lara] Amer Univ Beirut, Fac Agr & Food Sci, Dept Nutr & Food Sci, Beirut, Lebanon.
   [Nasreddine, Lara; Ismaeel, Hussain; Nasrallah, Mona P. P.; Zgheib, Nathalie K. K.] Amer Univ Beirut, Vasc Med Program, Beirut, Lebanon.
   [Ismaeel, Hussain] Amer Univ Beirut, Fac Med, Dept Internal Med, Div Cardiol, Beirut, Lebanon.
   [Nasrallah, Mona P. P.] Amer Univ Beirut, Fac Med, Dept Internal Med, Div Endocrinol,Med Ctr, Beirut, Lebanon.
   [Zgheib, Nathalie K. K.] Amer Univ Beirut, Fac Med, Dept Pharmacol & Toxicol, Beirut, Lebanon.
C3 American University of Beirut; American University of Beirut; American
   University of Beirut; Alfaisal University; American University of
   Beirut; American University of Beirut; American University of Beirut;
   American University of Beirut; American University of Beirut
RP Nasrallah, MP; Zgheib, NK (corresponding author), Amer Univ Beirut, Vasc Med Program, Beirut, Lebanon.; Nasrallah, MP (corresponding author), Amer Univ Beirut, Fac Med, Dept Internal Med, Div Endocrinol,Med Ctr, Beirut, Lebanon.; Zgheib, NK (corresponding author), Amer Univ Beirut, Fac Med, Dept Pharmacol & Toxicol, Beirut, Lebanon.
EM mn36@aub.edu.lb; nk16@aub.edu.lb
RI Tamim, Hani/MXK-8650-2025
OI Tamim, Hani/0000-0002-2019-4362; Ismaeel, Hussain/0009-0009-5385-8370
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NR 51
TC 9
Z9 10
U1 0
U2 1
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD AUG 18
PY 2022
VL 13
AR 978747
DI 10.3389/fendo.2022.978747
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 4O8ZB
UT WOS:000854981400001
PM 36060975
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Tain, YL
   Hsu, CN
AF Tain, You-Lin
   Hsu, Chien-Ning
TI Does maternal consumption of nutritive and non-nutritive sweeteners
   result in offspring hypertension?
SO FRONTIERS IN NUTRITION
LA English
DT Review
DE developmental origins of health and disease; pregnancy; sweetener;
   hypertension; fructose; sugar; sugar-sweetened beverage
ID PROGRAMMED HYPERTENSION; BLOOD-PRESSURE; OXIDATIVE STRESS;
   SEX-DIFFERENCES; TRANSCRIPTOME ANALYSIS; RENAL TRANSCRIPTOME;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; SODIUM SACCHARIN; FRUCTOSE
AB The consumption of nutritive and non-nutritive sweeteners (NNS) has increased significantly in recent decades. The nutritional status of pregnant women plays a crucial role in determining the likelihood of their offspring developing hypertension in adulthood. While NNSs provide a sweet taste without adding to sugar intake, emerging evidence suggests that maternal consumption of not only nutritive sweeteners (such as fructose) but also NNS may lead to adverse outcomes in offspring, including hypertension. This review provides an overview of the latest research connecting maternal intake of sweeteners to the long-term risk of hypertension in offspring. We examine proposed mechanisms underlying the programming of offspring hypertension by sweeteners, encompassing oxidative stress, dysregulated nutrient sensing signals, abnormal renin-angiotensin system, transcriptome changes, and dysbiotic gut microbiota. Additionally, we outline preventive strategies that can help alleviate offspring hypertension programmed by maternal diets high in sweeteners. Recent advancements in understanding the mechanisms through which maternal consumption of nutritive and non-nutritive sweeteners contributes to offspring hypertension offer promise for addressing this widespread health concern at its developmental roots. Nonetheless, further research is needed to educate the public about the safety of sweetener consumption during pregnancy and lactation.
C1 [Tain, You-Lin] Kaohsiung Chang Gung Mem Hosp, Div Pediat Nephrol, Kaohsiung, Taiwan.
   [Tain, You-Lin] Kaohsiung Chang Gung Mem Hosp, Inst Translat Res Biomed, Kaohsiung, Taiwan.
   [Tain, You-Lin] Chang Gung Univ, Coll Med, Taoyuan, Taiwan.
   [Hsu, Chien-Ning] Kaohsiung Chang Gung Mem Hosp, Dept Pharm, Kaohsiung, Taiwan.
   [Hsu, Chien-Ning] Kaohsiung Med Univ, Sch Pharm, Kaohsiung, Taiwan.
C3 Chang Gung Memorial Hospital; Chang Gung Memorial Hospital; Chang Gung
   University; Chang Gung Memorial Hospital; Kaohsiung Medical University
RP Hsu, CN (corresponding author), Kaohsiung Chang Gung Mem Hosp, Dept Pharm, Kaohsiung, Taiwan.; Hsu, CN (corresponding author), Kaohsiung Med Univ, Sch Pharm, Kaohsiung, Taiwan.
EM chien_ning_hsu@hotmail.com
RI Hsu, Chien-Ning/GLS-4014-2022; Tain, You-Lin/H-2827-2019
FU Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan [CORPG8P0533,
   CMRPG8M0721, CMRPG8M0722, CMRPG8M0751, CMRPG8M0752, CORPG8P0563]
FX The author(s) declare that financial support was received for the
   research, authorship, and/or publication of this article. This work was
   supported by Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan,
   under grants nos. CORPG8P0533, CMRPG8M0721, CMRPG8M0722, CMRPG8M0751,
   CMRPG8M0752, and CORPG8P0563.
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NR 136
TC 0
Z9 0
U1 1
U2 1
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD JAN 22
PY 2025
VL 12
AR 1464269
DI 10.3389/fnut.2025.1464269
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA U6B2V
UT WOS:001412618200001
PM 39911806
OA gold
DA 2025-06-11
ER

PT J
AU Aussem, A
   Ludwig, K
AF Aussem, Andrew
   Ludwig, Kirsten
TI The Potential for Reducing Lynch Syndrome Cancer Risk with Nutritional
   Nrf2 Activators
SO NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
LA English
DT Article
ID DNA MISMATCH REPAIR; GREEN TEA EXTRACT; I CLINICAL-TRIAL;
   COLORECTAL-CANCER; OXIDATIVE STRESS; DIALLYL TRISULFIDE;
   MOLECULAR-MECHANISMS; ANTIOXIDANT ACTIVITY; METABOLIC SYNDROME;
   PANCREATIC-CANCER
AB Lynch syndrome (LS), is an autosomal dominant disorder predisposing patients to multiple cancers, predominantly colorectal (CRC) and endometrial, and is implicated in 2-4% of all CRC cases. LS is characterized by mutations of four mismatch repair (MMR) genes which code for proteins responsible for recognizing and repairing DNA lesions occurring through multiple mechanisms including oxidative stress (OS). Increased OS can cause DNA mutations and is considered carcinogenic. Due to reduced MMR activity, LS patients have an increased risk of cancer as a result of a decreased ability to recognize and repair DNA lesions caused by OS. Due to its carcinogenic properties, reducing the level of OS may reduce the risk of cancer. Nutritional Nrf2 activators have been shown to reduce the risk of carcinogenesis in the general population through activation of the endogenous antioxidant system. Common nutritional Nrf2 activators include sulforaphane, curcumin, DATS, quercetin, resveratrol, and EGCG. Since LS patients are more susceptible to carcinogenesis caused by OS, it is hypothesized that nutritional Nrf2 activators may have the potential to reduce the risk of cancer in those with LS by modulating OS and inflammation. The purpose of this paper is to review the available evidence in support of this statement.
C1 [Aussem, Andrew; Ludwig, Kirsten] Hawthorn Univ, Whitethorn, CA 95589 USA.
   [Aussem, Andrew] McMaster Univ, Hamilton, ON, Canada.
   [Ludwig, Kirsten] Univ Calif Los Angeles, Semel Inst Neurosci & Behav, Los Angeles, CA USA.
C3 McMaster University; University of California System; University of
   California Los Angeles
RP Aussem, A (corresponding author), Hawthorn Univ, Whitethorn, CA 95589 USA.; Aussem, A (corresponding author), McMaster Univ, Hamilton, ON, Canada.
EM Andrewaussem@gmail.com
RI Ludwig, Kirsten/LXB-2452-2024
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NR 139
TC 3
Z9 3
U1 0
U2 3
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 0163-5581
EI 1532-7914
J9 NUTR CANCER
JI Nutr. Cancer
PD MAR 16
PY 2021
VL 73
IS 3
BP 404
EP 419
DI 10.1080/01635581.2020.1751215
EA APR 2020
PG 16
WC Oncology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Nutrition & Dietetics
GA QI0XD
UT WOS:000558840500001
PM 32281399
DA 2025-06-11
ER

PT J
AU Chang, JC
   Yen, AMF
   Chen, HH
   Chen, SLS
   Chiu, SYH
   Fann, JCY
   Lee, CS
AF Chang, Jung-Chen
   Yen, Amy Ming-Fang
   Chen, Hsiu-Hsi
   Chen, Sam Li-Sheng
   Chiu, Sherry Yueh-Hsia
   Fann, Jean Ching-Yuan
   Lee, Chau-Shoun
TI Comorbid diseases as risk factors for incident posttraumatic stress
   disorder (PTSD) in a large community cohort (KCIS no. PSY4)
SO SCIENTIFIC REPORTS
LA English
DT Article
ID MOTOR-VEHICLE ACCIDENTS; DSM-IV DISORDERS; METABOLIC SYNDROME;
   PREDICTORS; SYMPTOMS; ADULTS; PREVALENCE; TRAUMA; HEALTH; US
AB Nature disasters and terrorist attacks have occurred globally in recent years. Posttraumatic stress disorder (PTSD) has gained increasing attention, but its incidence and comorbidities in the general population are different from those inside the disaster areas. The present study estimated incident PTSD and comorbid diseases for over a decade in a cohort from a community-based integrated screening program. Factors associated with the incidence of PTSD were analyzed using Cox regression models. PTSD incidence was estimated as 81 per 105 person-years. Incidence was higher in females than in males and one-year increments in age lowered the risk for PTSD by 3%. Adjusting for other factors, cardiovascular heart disease (adjusted hazard ratio (aHR) = 1.45, 95% confidence interval (CI): 1.03-2.04), bipolar disorder (aHR = 1.86, 95% CI: 1.07-3.24) and major depressive disorder (aHR = 7.03, 95% CI: 5.02-9.85) all significantly increased 45%, 86% and 603%, respectively, the risk of developing PTSD. The low rate of people with incident PTSD receiving treatment in this community health screening population implies there is room for improvement in terms of early detection and intervention. Clinical preventive efforts may be made for patients seeking general medical help, especially those with cardiovascular disorders or mood disorders.
C1 [Chang, Jung-Chen] Natl Taiwan Univ, Coll Med, Sch Nursing, Taipei, Taiwan.
   [Chang, Jung-Chen] Natl Taiwan Univ Hosp, Taipei, Taiwan.
   [Yen, Amy Ming-Fang; Chen, Sam Li-Sheng] Taipei Med Univ, Coll Oral Med, Sch Oral Hyg, Taipei, Taiwan.
   [Chen, Hsiu-Hsi] Natl Taiwan Univ, Coll Publ Hlth, Grad Inst Epidemiol & Prevent Med, Div Biostat, Taipei, Taiwan.
   [Chiu, Sherry Yueh-Hsia] Chang Gung Univ, Coll Management, Dept Hlth Care Management, Taoyuan, Taiwan.
   [Fann, Jean Ching-Yuan] Kainan Univ, Coll Healthcare Management, Dept Hlth Ind Management, Taoyuan, Taoyuan County, Taiwan.
   [Lee, Chau-Shoun] Mackay Med Coll, Dept Med, New Taipei, Taiwan.
   [Lee, Chau-Shoun] Mackay Mem Hosp, Dept Psychiat, Taipei, Taiwan.
C3 National Taiwan University; National Taiwan University; National Taiwan
   University Hospital; Taipei Medical University; National Taiwan
   University; Chang Gung University; Nan Kai University Technology; Mackay
   Medical College; Mackay Memorial Hospital
RP Lee, CS (corresponding author), Mackay Med Coll, Dept Med, New Taipei, Taiwan.; Lee, CS (corresponding author), Mackay Mem Hosp, Dept Psychiat, Taipei, Taiwan.
EM csleepsyc@gmail.com
RI Chen, Jung-Chien/W-1862-2019; Hsu, Chien-Ning/GLS-4014-2022
OI CHANG, JUNG-CHEN/0000-0001-8651-2602; Chen, Tony
   Hsiu-Hsi/0000-0002-5799-6705; Chiu, Sherry Yueh-Hsia/0000-0002-7207-7088
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NR 59
TC 9
Z9 10
U1 0
U2 10
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD JAN 27
PY 2017
VL 7
AR 41276
DI 10.1038/srep41276
PG 8
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Science & Technology - Other Topics
GA EI9AK
UT WOS:000392799300001
PM 28128220
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Roskoden, FC
   Krüger, J
   Vogt, LJ
   Gärtner, S
   Hannich, HJ
   Steveling, A
   Lerch, MM
   Aghdassi, AA
AF Roskoden, Frederick Charles
   Krueger, Janine
   Vogt, Lena Johanna
   Gaertner, Simone
   Hannich, Hans Joachim
   Steveling, Antje
   Lerch, Markus M.
   Aghdassi, Ali A.
TI Physical Activity, Energy Expenditure, Nutritional Habits, Quality of
   Sleep and Stress Levels in Shift-Working Health Care Personnel
SO PLOS ONE
LA English
DT Article
ID METABOLIC SYNDROME; DIETARY PATTERNS; CHRONIC DISEASE; ACCELEROMETER;
   RISK; PEDOMETER; OBESITY; ASSOCIATION; BIOMARKERS; DISORDERS
AB Background
   Among health care personnel working regular hours or rotating shifts can affect parameters of general health and nutrition. We have investigated physical activity, sleep quality, metabolic activity and stress levels in health care workers from both groups.
   Methods
   We prospectively recruited 46 volunteer participants from the workforce of a University Medical Department of which 23 worked in rotating shifts (all nursing) and 21 non-shift regular hours (10 nursing, 13 clerical staff). All were investigated over 7 days by multisensory accelerometer (SenseWear Bodymedia (R) armband) and kept a detailed food diary. Physical activity and resting energy expenditure (REE) were measured in metabolic equivalents of task (METs). Quality of sleep was assessed as Pittsburgh Sleeping Quality Index and stress load using the Trier Inventory for Chronic Stress questionnaire (TICS).
   Results
   No significant differences were found for overall physical activity, steps per minute, time of exceeding the 3 METs level or sleep quality. A significant difference for physical activity during working hours was found between shift-workers vs. non-shift-workers (p<0.01) and for shift-working nurses (median = 2.1 METs SE = 0.1) vs. non-shift-working clerical personnel (median = 1.5 METs SE = 0.07, p<0.05). Non-shift-working nurses had a significantly lower REE than the other groups (p<0.05). The proportion of fat in the diet was significantly higher (p<0.05) in the office worker group (median = 42% SE = 1.2) whereas shift-working nurses consumed significantly more carbohydrates (median = 46% SE = 1.4) than clerical staff (median = 41% SE = 1.7). Stress assessment by TICS confirmed a significantly higher level of social overload in the shift working group (p<0.05).
   Conclusion
   In this prospective cohort study shift-working had no influence on overall physical activity. Lower physical activity during working hours appears to be compensated for during off-hours. Differences in nutritional habits and stress load warrant larger scale trials to determine the effect on implicit health-associated conditions.
C1 [Roskoden, Frederick Charles; Krueger, Janine; Vogt, Lena Johanna; Gaertner, Simone; Steveling, Antje; Lerch, Markus M.; Aghdassi, Ali A.] Univ Med Greifswald, Dept Med A, Greifswald, Germany.
   [Hannich, Hans Joachim] Univ Med Greifswald, Inst Med Psychol, Greifswald, Germany.
C3 Universitat Greifswald; Greifswald Medical School; Universitat
   Greifswald; Greifswald Medical School
RP Lerch, MM (corresponding author), Univ Med Greifswald, Dept Med A, Greifswald, Germany.
EM lerch@uni-greifswald.de
RI Aghdassi, Ali/X-5836-2019; Lerch, Markus M./E-2206-2016
OI Lerch, Markus M./0000-0002-9643-8263; Aghdassi, Ali/0000-0002-0569-7316
FU Baxter; Nutricia
FX The authors received no specific or direct funding for this work. No
   direct grants were given. JK, LJV and SG were supported by unrestricted
   grants for the Domagk scholarship provided through donations from Baxter
   and Nutricia. This study was approved by the local ethics committee and
   supported by unrestricted grants for the Domagk scholarship of J.K,
   L.J.V. and S.G. provided through donations from Baxter and Nutricia.
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NR 47
TC 62
Z9 66
U1 1
U2 46
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JAN 12
PY 2017
VL 12
IS 1
AR e0169983
DI 10.1371/journal.pone.0169983
PG 21
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA EH7JQ
UT WOS:000391949500113
PM 28081231
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Clark, CCA
   Holder, P
   Boardman, FK
   Moody, L
   Cowlard, J
   Allen, L
   Walter, C
   Bonham, JR
   Chudleigh, J
AF Clark, Corinna C. A.
   Holder, Pru
   Boardman, Felicity K.
   Moody, Louise
   Cowlard, Jacqui
   Allen, Lorna
   Walter, Claire
   Bonham, James R.
   Chudleigh, Jane
TI International Perspectives of Extended Genetic Sequencing When Used as
   Part of Newborn Screening to Identify Cystic Fibrosis
SO INTERNATIONAL JOURNAL OF NEONATAL SCREENING
LA English
DT Article
DE cystic fibrosis; next-generation sequencing; genomics; CRMS/CFSPID
ID INCONCLUSIVE DIAGNOSIS; PERFORMANCE; EXPERIENCE; OUTCOMES
AB There is increasing interest in using extended genetic sequencing (EGS) in newborn screening (NBS) for cystic fibrosis (CF). How this is implemented will change the number of children being given an uncertain outcome of CRMS/CFSPID (cystic fibrosis transmembrane conductance regulator (CFTR)-related metabolic syndrome/CF Screen Positive Inconclusive Diagnosis), probable carrier results, and the number of missed CF diagnoses. An international survey of CF health professionals was used to gather views on two approaches to EGS-specific (may reduce detection of CRMS/CFSID but miss some CF cases) versus sensitive (may increase detection of CRMS/CFSPID but avoid missing more CF cases). Health professionals acknowledged the anxiety caused to parents (and health professionals) from the uncertainty surrounding the prognosis and management of CRMS/CFSPID. However, most preferred the sensitive approach, as overall, identifying more cases of CRMS/CFSPID was viewed as less physically and psychologically damaging than a missed case of CF. The importance of early diagnosis and treatment for CF to ensure better health outcomes and reducing diagnostic odysseys for parents were highlighted. A potential benefit to identifying more children with CRMS/CFSPID included increasing knowledge to obtain a better understanding of how these children should best be managed in the future.
C1 [Clark, Corinna C. A.; Boardman, Felicity K.] Univ Warwick, Warwick Med Sch, Coventry CV4 7AL, England.
   [Holder, Pru; Chudleigh, Jane] Kings Coll London, Florence Nightingale Fac Nursing Midwifery & Palli, London SE5 9PJ, England.
   [Moody, Louise] Coventry Univ, Ctr Arts Memory & Communities, Coventry CV1 5FB, England.
   [Cowlard, Jacqui] Royal London Childrens Hosp, Paediat Resp Med, London E1 1FR, England.
   [Allen, Lorna; Walter, Claire] Cyst Fibrosis Trust, London EC3N 1RE, England.
   [Bonham, James R.] Sheffield Childrens NHS Fdn Trust, Pharm Diagnost & Genet, Sheffield S10 2TH, England.
C3 University of Warwick; University of London; King's College London;
   Coventry University; Sheffield Children's NHS Foundation Trust
RP Clark, CCA (corresponding author), Univ Warwick, Warwick Med Sch, Coventry CV4 7AL, England.
EM corinna.clark@warwick.ac.uk; pru.holder@kcl.ac.uk;
   felicity.boardman@warwick.ac.uk; l.moody@coventry.ac.uk;
   j.bonham@nhs.net; jane.2.chudleigh@kcl.ac.uk
RI ; Moody, Louise/Q-5133-2017
OI Holder, Pru/0000-0002-1036-978X; Bonham, James/0009-0004-9485-6754;
   Clark, Corinna/0000-0002-1077-9383; Moody, Louise/0000-0003-2326-4124;
   Boardman, Felicity/0000-0002-3268-6276
FU NHS England/Department of Health and Social Care
FX This research was funded by NHS England/Department of Health and Social
   Care, grantnumber CFNGS. The article processing charge was funded by NHS
   England/Department of Health and Social Care.
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NR 33
TC 1
Z9 1
U1 0
U2 0
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2409-515X
J9 INT J NEONAT SCREEN
JI Int. J. Neonatal Screen.
PD JUN
PY 2024
VL 10
IS 2
AR 31
DI 10.3390/ijns10020031
PG 15
WC Genetics & Heredity; Pediatrics
WE Emerging Sources Citation Index (ESCI)
SC Genetics & Heredity; Pediatrics
GA WO6I7
UT WOS:001255853100001
PM 38651396
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Maymone, AC
   Baillargeon, JP
   Ménard, J
   Ardilouze, JL
AF Maymone, Ana Cristina
   Baillargeon, Jean-Patrice
   Menard, Julie
   Ardilouze, Jean-Luc
TI Oral hypoglycemic agents for gestational diabetes mellitus?
SO EXPERT OPINION ON DRUG SAFETY
LA English
DT Review
DE gestational diabetes mellitus; glibenclamide; glyburide; insulin;
   metformin; oral hypoglycemic agents
ID POLYCYSTIC-OVARY-SYNDROME; METFORMIN THERAPY; CONGENITAL-MALFORMATIONS;
   METABOLIC SYNDROME; PREGNANCY; WOMEN; GLYBURIDE; INSULIN; MANAGEMENT;
   OBESITY
AB Introduction: Gestational diabetes mellitus (GDM), the most frequent medical complication of pregnancy, is associated with several adverse outcomes over the short-and long-term for both mother and offspring. Standard treatment for GDM consists of insulin injections. Oral hypoglycemic agents (OHAs), on the other hand, are still the subject of controversy. Although OHAs are seemingly as efficient as insulin and may provide better quality of life, congenital malformations and unknown long-term effects are still feared.
   Areas covered: Recent data on the pharmacokinetics of two OHAs (glyburide and metformin) and their clinical use for GDM are reviewed, with a focus on clinical trials and observational studies comparing insulin with glyburide or metformin (1960 - 2010). The review will provide a comprehensive overview of the pros and cons of OHA usage, an appreciation of OHAs' efficiency for the purpose of controlling glycemia and embryogenetic basics relating to congenital malformations.
   Expert opinion: While insulin treatment is an effective therapy for controlling maternal glycemia, it nevertheless requires sufficient education and skills on the part of the patient to manage properly and may cause hypoglycemia, fear and anxiety. Oral treatment as a more user-friendly alternative may thus facilitate the control of GDM in some patients.
C1 [Maymone, Ana Cristina; Baillargeon, Jean-Patrice; Menard, Julie; Ardilouze, Jean-Luc] CHU Sherbrooke, Dept Med, Div Endocrinol, Sherbrooke, PQ J1H 5N4, Canada.
C3 University of Sherbrooke
RP Ardilouze, JL (corresponding author), Univ Sherbrooke, Div Endocrinol, Dept Med, Sherbrooke, PQ J1K 2R1, Canada.
EM Jean-Luc.Ardilouze@USherbrooke.ca
RI BAILLARGEON, JEAN-PATRICE/HNQ-9030-2023
OI Baillargeon, Jean-Patrice/0000-0002-1336-081X
FU Canadian Institutes of Health Research (CIHR)
FX The authors declare no conflict of interest. J-L Ardilouze is supported
   by a Canadian Institutes of Health Research (CIHR) New Investigator
   Award (scholarship).
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NR 100
TC 28
Z9 32
U1 0
U2 5
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1474-0338
EI 1744-764X
J9 EXPERT OPIN DRUG SAF
JI Expert Opin. Drug Saf.
PD MAR
PY 2011
VL 10
IS 2
BP 227
EP 238
DI 10.1517/14740338.2011.521740
PG 12
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 726SG
UT WOS:000287745800007
PM 21210750
DA 2025-06-11
ER

PT J
AU Kilinç, S
   Sevgili, AM
AF Kilinc, Sevtap
   Sevgili, Ayse Meltem
TI Nonalcoholic Fatty Liver Disease and Topiramate as an Antiobesity Drug
SO GAZI MEDICAL JOURNAL
LA English
DT Review
DE Nonalcoholic fatty liver disease; hepatic steatosis; oxidative stress;
   obesity; vitamin E; topiramate
ID CONTROLLED-RELEASE PHENTERMINE/TOPIRAMATE; PLACEBO-CONTROLLED TRIAL;
   WEIGHT-LOSS; OBESE ADULTS; VITAMIN-E; STEATOHEPATITIS; DIAGNOSIS;
   PREVALENCE; OVERWEIGHT; PIOGLITAZONE
AB Nonalcoholic fatty liver disease (NAFLD) affects approximately one out of every 4 people and is the most common chronic liver disease worldwide. There are some risks factor such as obesity, type 2 diabetes mellitus, dyslipidemia and metabolic syndrome for the fatty liver. NAFLD can be presented as simple steatosis or steatohepatitis and can progress to liver cirrhosis. There is an important role of oxidative stress in etiopathogenesis of NAFLD so it is possible that antioxidant agents may have a positive effect on NAFLD. Although there is currently no approved pharmacological agent for the treatment of NAFLD, treatment guidelines for this desease include the use of vitamin E for its antioxidant activity. There are yet many advances to be made in the pharmacotherapy of NAFLD. Topiramate (TPM) is primarily used for epilepsy but it is also known for its weight loss, neuroprotective and antioxidant effects and many studies regarding these effects are available in the literature. In this sense, considering that TPM has both weight loss and antioxidant effects, it may be an option for the treatment of NAFLD. In this review, we aimed to focus on NAFLD and the properties and potential effects of TPM.
C1 [Kilinc, Sevtap; Sevgili, Ayse Meltem] Gazi Univ, Dept Physiol, Fac Med, Ankara, Turkey.
C3 Gazi University
RP Kilinç, S (corresponding author), Gazi Univ, Dept Physiol, Fac Med, Ankara, Turkey.
EM sevtap.kilinc@gazi.edu.tr
RI Sevgili, Ayse/J-3448-2014; Kılınç, Sevtap/ISP-2968-2023
OI Kilinc, Sevtap/0000-0002-4162-1554
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TC 0
Z9 0
U1 0
U2 10
PU GAZI UNIV, FAC MED
PI ANKARA
PA GAZI UNIV, FAC MED, ANKARA, 06500, TURKEY
SN 2147-2092
J9 GAZI MED J
JI Gazi Med. J.
PY 2022
VL 33
IS 1
BP 108
EP 113
DI 10.12996/gmj.2022.27
PG 6
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA XT0QX
UT WOS:000733303100026
OA gold
DA 2025-06-11
ER

PT J
AU Galmés, S
   Serra, F
   Palou, A
AF Galmes, Sebastia
   Serra, Francisca
   Palou, Andreu
TI Vitamin E Metabolic Effects and Genetic Variants: A Challenge for
   Precision Nutrition in Obesity and Associated Disturbances
SO NUTRIENTS
LA English
DT Review
DE genetic variant; tocopherol; nutrigenetics; metabolic syndrome; obesity;
   vitamin E
ID HIGH-DENSITY-LIPOPROTEIN; TOCOPHEROL TRANSFER PROTEIN; GENOME-WIDE
   ASSOCIATION; FAT-SOLUBLE VITAMINS; SCAVENGER RECEPTOR EXPRESSION;
   OMEGA-HYDROXYLASE PATHWAY; APOLIPOPROTEIN-E GENOTYPE; ALPHA-TOCOPHEROL;
   SR-BI; INTESTINAL-ABSORPTION
AB Vitamin E (VE) has a recognized leading role as a contributor to the protection of cell constituents from oxidative damage. However, evidence suggests that the health benefits of VE go far beyond that of an antioxidant acting in lipophilic environments. In humans, VE is channeled toward pathways dealing with lipoproteins and cholesterol, underlining its relevance in lipid handling and metabolism. In this context, both VE intake and status may be relevant in physiopathological conditions associated with disturbances in lipid metabolism or concomitant with oxidative stress, such as obesity. However, dietary reference values for VE in obese populations have not yet been defined, and VE supplementation trials show contradictory results. Therefore, a better understanding of the role of genetic variants in genes involved in VE metabolism may be crucial to exert dietary recommendations with a higher degree of precision. In particular, genetic variability should be taken into account in targets concerning VE bioavailability per se or concomitant with impaired lipoprotein transport. Genetic variants associated with impaired VE liver balance, and the handling/resolution of oxidative stress might also be relevant, but the core information that exists at present is insufficient to deliver precise recommendations.
C1 [Galmes, Sebastia; Serra, Francisca; Palou, Andreu] Univ Illes Balears, NUO Grp, Lab Mol Biol Nutr & Biotechnol, Palma De Mallorca 07122, Spain.
   [Galmes, Sebastia; Serra, Francisca; Palou, Andreu] CIBER Fisiopatol Obesidad & Nutr CIBEROBN, Madrid 28029, Spain.
   [Galmes, Sebastia; Serra, Francisca; Palou, Andreu] Inst Invest Sanitaria Illes Balears IdISBa, Palma De Mallorca 07120, Spain.
C3 Universitat de les Illes Balears; CIBER - Centro de Investigacion
   Biomedica en Red; CIBEROBN; Institut Investigacio Sanitaria Illes
   Balears (IdISBa)
RP Serra, F (corresponding author), Univ Illes Balears, NUO Grp, Lab Mol Biol Nutr & Biotechnol, Palma De Mallorca 07122, Spain.; Serra, F (corresponding author), CIBER Fisiopatol Obesidad & Nutr CIBEROBN, Madrid 28029, Spain.; Serra, F (corresponding author), Inst Invest Sanitaria Illes Balears IdISBa, Palma De Mallorca 07120, Spain.
EM s.galmes@uib.cat; francisca.serra@uib.es; andreu.palou@uib.es
RI Galmés, Sebastià/ABB-1742-2020; Palou, Andreu/K-9881-2014; Serra,
   Francisca/B-8641-2008
OI Galmes Monroig, Sebastia/0000-0002-4243-9527; Palou,
   Andreu/0000-0002-0295-4452; Serra, Francisca/0000-0002-8307-9732
FU Spanish Government (MINECO/FEDER) [AGL2015-67019-P]
FX This work was supported by project AGL2015-67019-P financed by the
   Spanish Government (MINECO/FEDER, UE).
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NR 162
TC 59
Z9 62
U1 1
U2 18
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 2072-6643
J9 NUTRIENTS
JI Nutrients
PD DEC
PY 2018
VL 10
IS 12
AR 1919
DI 10.3390/nu10121919
PG 20
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA HG6EG
UT WOS:000455073200100
PM 30518135
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Nickelson, KJ
   Stromsdorfer, KL
   Pickering, RT
   Liu, TW
   Ortinau, LC
   Keating, AF
   Perfield, J
AF Nickelson, Karen J.
   Stromsdorfer, Kelly L.
   Pickering, R. Taylor
   Liu, Tzu-Wen
   Ortinau, Laura C.
   Keating, Aileen F.
   Perfield, JamesW., II
TI A Comparison of Inflammatory and Oxidative Stress Markers in Adipose
   Tissue from Weight-Matched Obese Male and Female Mice
SO EXPERIMENTAL DIABETES RESEARCH
LA English
DT Article
ID DIET-INDUCED OBESITY; INSULIN-RESISTANCE; METABOLIC SYNDROME; ADIPOCYTE
   DEATH; FAT; SENSITIVITY; POLARIZATION; DYSFUNCTION; DISEASE; PROTEIN
AB Expansion of intra-abdominal adipose tissue and the accompanying inflammatory response has been put forward as a unifying link between obesity and the development of chronic diseases. However, an apparent sexual dimorphism exists between obesity and chronic disease risk due to differences in the distribution and abundance of adipose tissue. A range of experimental protocols have been employed to demonstrate the role of estrogen in regulating health benefits; however, most studies are confounded by significant differences in body weight and adiposity. Therefore, the purpose of this study was to compare weight-matched obese male and female mice to determine if the sex-dependent health benefits remain when body weight is similar. The development of obesity in female mice receiving a high-fat diet was delayed; however, subsequent comparisons of weight-matched obese mice revealed greater adiposity in obese female mice. Despite excess adiposity and enlarged adipocyte size, obese females remained more glucose tolerant than weight-matched male mice, and this benefit was associated with increased expression of adiponectin and reductions in immune cell infiltration and oxidative stress in adipose tissue. Therefore, the protective benefits of estrogen persist in the obese state and appear to improve the metabolic phenotype of adipose tissue and the individual.
C1 [Nickelson, Karen J.; Stromsdorfer, Kelly L.; Pickering, R. Taylor; Liu, Tzu-Wen; Ortinau, Laura C.; Perfield, JamesW., II] Univ Missouri, Dept Nutr & Exercise Physiol, Columbia, MO 65211 USA.
   [Keating, Aileen F.] Iowa State Univ, Dept Anim Sci, Ames, IA 50011 USA.
   [Perfield, JamesW., II] Univ Missouri, Dept Food Sci, Columbia, MO 65211 USA.
C3 University of Missouri System; University of Missouri Columbia; Iowa
   State University; University of Missouri System; University of Missouri
   Columbia
RP Perfield, J (corresponding author), Univ Missouri, Dept Nutr & Exercise Physiol, 256 William Stringer Wing, Columbia, MO 65211 USA.
EM perfieldj@missouri.edu
RI Pickering, Richard/KIC-9473-2024
OI Pickering, Richard/0000-0002-5243-4068; Moseley,
   Brian/0000-0001-8573-7340; Cross, Tzu-Wen/0000-0002-8856-8578
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NR 35
TC 73
Z9 85
U1 0
U2 3
PU HINDAWI PUBLISHING CORPORATION
PI NEW YORK
PA 410 PARK AVENUE, 15TH FLOOR, #287 PMB, NEW YORK, NY 10022 USA
SN 1687-5214
J9 EXP DIABETES RES
JI Exp. Diabetes Res.
PY 2012
AR 859395
DI 10.1155/2012/859395
PG 8
WC Endocrinology & Metabolism; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Research & Experimental Medicine
GA 963MI
UT WOS:000305624400001
PM 22957247
OA Green Published, Green Submitted, hybrid
DA 2025-06-11
ER

PT J
AU Zhu, YY
   Yang, HX
   Deng, JJ
   Fan, DD
AF Zhu, Yanyan
   Yang, Haixia
   Deng, Jianjun
   Fan, Daidi
TI Ginsenoside Rg5 Improves Insulin Resistance and Mitochondrial Biogenesis
   of Liver via Regulation of the Sirt1/PGC-1α Signaling Pathway in db/db
   Mice
SO JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
LA English
DT Article
DE ginsenoside Rg5; T2DM; insulin sensitivity; mitochondrial dysfunction;
   Sirt1
ID NF-KAPPA-B; DYSFUNCTION; DISEASE; METABOLISM; STRESS; PATHOGENESIS;
   INFLAMMATION; SENSITIVITY; INHIBITION; FISSION
AB Type 2 diabetes mellitus (T2DM) is a common metabolic syndrome that decreases insulin sensitivity and mitochondrial biogenesis in the liver. Our previous study demonstrated that ginsenoside Rg5 (Rg5) could attenuate renal injury in diabetic mice but its underlying mechanism in mitochondrial biogenesis and insulin sensitivity remains poorly understood. In this study, we found that Rg5 intervention significantly inhibited blood glucose increases in db/db mice, improved liver function damage and hepatocyte apoptosis, and activated the IRS-1/phosphatidylinositol 3-kinase/AKT insulin metabolism signaling pathway. Rg5 treatment also increased the level of glycogen synthesis and activated sirtuin1 (Sirt1) to increase glucose uptake and insulin sensitivity in insulin-resistant HepG2 (IR-HepG2) cells. Rg5 intervention also effectively improved liver oxidative stress and inflammation in db/db mice and increased mitochondrial biogenesis caused by T2DM. Additionally, the Rg5 treatment increased the mitochondrial mass in IR-HepG2 cells and activated Sirt1 to regulate the Sirt1/PGC-1 alpha/mitofusin-2 mitochondrial biosynthesis pathway. Our findings demonstrated that Rg5 enhanced liver mitochondrial biogenesis and insulin sensitivity in db/db mice by activating the Sirt1/PGC-1 alpha signaling pathway, suggesting the potential of Rg5 as a natural product for T2DM interventions.
C1 [Zhu, Yanyan; Deng, Jianjun; Fan, Daidi] Northwest Univ, Sch Chem Engn, Shaanxi Key Lab Degradable Biomed Mat, Xian 710069, Peoples R China.
   [Zhu, Yanyan; Deng, Jianjun; Fan, Daidi] Northwest Univ, Shaanxi R&D Ctr Biomat & Fermentat Engn, Sch Chem Engn, Xian 710069, Peoples R China.
   [Zhu, Yanyan; Deng, Jianjun; Fan, Daidi] Northwest Univ, Biotechnol & Biomed Res Inst, Xian 710069, Peoples R China.
   [Yang, Haixia] Harvard Med Sch, Beth Israel Deaconess Med Ctr, Ctr Vasc Biol Res, Boston, MA 02215 USA.
C3 Northwest University Xi'an; Northwest University Xi'an; Northwest
   University Xi'an; Harvard University; Harvard Medical School; Harvard
   University Medical Affiliates; Beth Israel Deaconess Medical Center
RP Deng, JJ; Fan, DD (corresponding author), Northwest Univ, Sch Chem Engn, Shaanxi Key Lab Degradable Biomed Mat, Xian 710069, Peoples R China.; Deng, JJ; Fan, DD (corresponding author), Northwest Univ, Shaanxi R&D Ctr Biomat & Fermentat Engn, Sch Chem Engn, Xian 710069, Peoples R China.; Deng, JJ; Fan, DD (corresponding author), Northwest Univ, Biotechnol & Biomed Res Inst, Xian 710069, Peoples R China.
EM dengjianjun@nwu.edu.cn; fandaidi@nwu.edu.cn
RI Jianjun, Deng/U-5306-2019; Yang, Haixia/AAH-3819-2020; Fan,
   daidi/J-1128-2017
OI Deng, Jianjun/0000-0002-3057-6997; Daidi, Fan/0000-0001-9798-1674
FU National Natural Science Foundation of China [21776228, 21978236,
   21978229]; Key Research and Development Program of Shaanxi
   [2019ZDLSF03-01-02]
FX This work was financially supported by the National Natural Science
   Foundation of China (21776228, 21978236, and 21978229) and the Key
   Research and Development Program of Shaanxi (2019ZDLSF03-01-02).
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NR 44
TC 26
Z9 29
U1 6
U2 70
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0021-8561
EI 1520-5118
J9 J AGR FOOD CHEM
JI J. Agric. Food Chem.
PD AUG 4
PY 2021
VL 69
IS 30
BP 8428
EP 8439
DI 10.1021/acs.jafc.1c02476
EA JUL 2021
PG 12
WC Agriculture, Multidisciplinary; Chemistry, Applied; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture; Chemistry; Food Science & Technology
GA TY4AZ
UT WOS:000683727500010
PM 34309383
DA 2025-06-11
ER

PT J
AU Zhang, XH
   Cui, L
   Chen, B
   Xiong, QZ
   Zhan, YQ
   Ye, JH
   Yin, QL
AF Zhang, Xuehong
   Cui, Liang
   Chen, Bin
   Xiong, Qinzhi
   Zhan, Yanqin
   Ye, Jinhua
   Yin, Qiulin
TI Effect of chromium supplementation on hs-CRP, TNF-α and IL-6 as risk
   factor for cardiovascular diseases: A meta-analysis of
   randomized-controlled trials
SO COMPLEMENTARY THERAPIES IN CLINICAL PRACTICE
LA English
DT Article
DE Chromium; Cardiovascular diseases; Myocardial infarction; Inflammation;
   Meta-analysis
ID POLYCYSTIC-OVARY-SYNDROME; OXIDATIVE STRESS; INSULIN-RESISTANCE;
   METABOLIC SYNDROME; DOUBLE-BLIND; LIPID PROFILE; INFLAMMATION;
   INTERLEUKIN-6; PICOLINATE; SECRETION
AB Background: The objective of this systematic review is to assess the relationship between chromium supplementation and inflammatory biomarkers levels (hs-CRP, TNF-alpha, IL-6) as risk factor for cardiovascular diseases. Recent studies raise questions regarding the potential of chromium supplementation to decrease the blood-levels of inflammatory markers, lowering cellular oxidative stress as markers of myocardial infarction; however, the results of the researches are inconclusive.
   Methods: The following databases including PubMed, Scopus, Cochran Library and Embase databases were systematically searched until April 2020. Analysis was performed using random-effect model.
   Results: The pooled findings for biomarkers of inflammation showed that chromium supplementation significantly reduced serum high-sensitivity C-reactive protein (hs-CRP) (WMD:-0.87 mg/dL, 95% CI:-1.49,-0.26), and tumor necrosis factor-alpha (TNF-alpha) (WMD:-0.97 pg/ml; 95% CI:-1.92,-0.01) and chromium insignificantly reduced interleukin-6 (IL-6) (WMD:-0.45 pg/ml, 95% CI:-1.18, 0.29).
   Conclusion: Overall, the results of this systematic review and meta-analysis imply that chromium supplementation may help to improve biomarkers of inflammation as markers of myocardial infarction.
C1 [Zhang, Xuehong; Yin, Qiulin] Nanchang Univ, Jiangxi Prov Peoples Hosp, Dept Cardiovasc Med, Affiliated Peoples Hosp, 92 Aiguo Rd, Nanchang 330006, Jiangxi, Peoples R China.
   [Cui, Liang] Nanchang Univ, Jiangxi Prov Peoples Hosp, Ultrasound, Affiliated Peoples Hosp, 92 Aiguo Rd, Nanchang 330006, Jiangxi, Peoples R China.
   [Chen, Bin] Wannian Cty Peoples Hosp, Internal Med, 6 Zhengda West St, Shangrao 335500, Jiangxi, Peoples R China.
   [Xiong, Qinzhi] Yifeng Cty Peoples Hosp, Internal Med, 30 Nanmen Rd, Yichun City 336300, Jiangxi, Peoples R China.
   [Zhan, Yanqin] First Peoples Hosp Linchuan Dist, Internal Med, 109 Longjin Rd, Fuzhou 344100, Jiangxi, Peoples R China.
   [Ye, Jinhua] Zhangshu City Peoples Hosp, Internal Med, 13 Yaodu Rd, Yichun City 331200, Jiangxi, Peoples R China.
C3 Nanchang University; Nanchang University
RP Yin, QL (corresponding author), Nanchang Univ, Jiangxi Prov Peoples Hosp, Dept Cardiovasc Med, Affiliated Peoples Hosp, 92 Aiguo Rd, Nanchang 330006, Jiangxi, Peoples R China.
EM yinqiulin_1972@sina.com
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NR 52
TC 25
Z9 26
U1 1
U2 7
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1744-3881
EI 1873-6947
J9 COMPLEMENT THER CLIN
JI Complement. Ther. Clin. Pract.
PD FEB
PY 2021
VL 42
AR 101291
DI 10.1016/j.ctcp.2020.101291
PG 8
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA QB9ZQ
UT WOS:000614494000015
PM 33321447
OA hybrid
DA 2025-06-11
ER

PT J
AU Alli, AA
   Brewer, EM
   Montgomery, DS
   Ghant, MS
   Eaton, DC
   Brown, LA
   Helms, MN
AF Alli, Abdel A.
   Brewer, Elizabeth M.
   Montgomery, Darrice S.
   Ghant, Marcus S.
   Eaton, Douglas C.
   Brown, Lou Ann
   Helms, My N.
TI Chronic ethanol exposure alters the lung proteome and leads to
   mitochondrial dysfunction in alveolar type 2 cells
SO AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
LA English
DT Article
DE mitochondrial stress; chronic alcohol ingestion; ENaC; gene chip array;
   mass spectrometry
ID EPITHELIAL SODIUM-CHANNEL; CHRONIC ALCOHOL-ABUSE; OXIDATIVE STRESS;
   ALDEHYDE DEHYDROGENASE; METABOLIC SYNDROME; TRANSPORT; ENAC;
   CONSUMPTION; AMILORIDE; HYPOXIA
AB The lungs can undergo irreversible damage from chronic alcohol consumption. Herein, we developed an animal model predisposed for edematous lung injury following chronic ingestion of alcohol to better understand the etiology of alcohol-related disorders. Using animal modeling, alongside high-throughput proteomic and microarray assays, we identified changes in lung protein and transcript in mice and rats, respectively, following chronic alcohol ingestion or a caloric control diet. Liquid chromatography-mass spectrometry identified several mitochondrial-related proteins in which the expression was upregulated following long-term alcohol ingestion in mice. Consistent with these observations, rat gene chip microarray analysis of alveolar cells obtained from animals maintained on a Lieber-DeCarli liquid alcohol diet confirmed significant changes in mitochondrial-related transcripts in the alcohol lung. Transmission electron microscopy revealed significant changes in the mitochondrial architecture in alcohol mice, particularly following lipopolysaccharide exposure. Chronic alcohol ingestion was also shown to worsen mitochondrial respiration, mitochondrial membrane polarization, and NAD(+) -to-NADH ratios in alveolar type 2 cells. In summary, our studies show causal connection between chronic alcohol ingestion and mitochondrial dysfunction, albeit the specific role of each of the mitochondrial-related proteins and transcripts identified in our study requires additional study.
C1 [Alli, Abdel A.; Eaton, Douglas C.; Helms, My N.] Emory Univ, Sch Med, Dept Physiol, Atlanta, GA USA.
   [Brewer, Elizabeth M.; Eaton, Douglas C.; Brown, Lou Ann; Helms, My N.] Emory Univ, Sch Med, Dept Pediat, Atlanta, GA USA.
   [Montgomery, Darrice S.; Ghant, Marcus S.] Clark Atlanta Univ, Dept Biol Sci, Atlanta, GA 30314 USA.
C3 Emory University; Emory University; Clark Atlanta University
RP Helms, MN (corresponding author), Dept Pediat, 2015 Uppergate Dr,Suite 314, Atlanta, GA 30030 USA.
EM mhelms@emory.edu
OI Eaton, Douglas/0000-0002-2686-6692; Montgomery,
   Darrice/0000-0003-2481-8432
FU Children's Healthcare of Atlanta [NIAAA P50 AA 135757, F32 KD093255-01,
   R37 DK037963]
FX Support for this research was provided by grants from Children's
   Healthcare of Atlanta (to M. N. Helms and L. A. Brown); NIAAA P50 AA
   135757 pilot award to M. N. Helms, F32 KD093255-01 to A. A. Alli; and
   R37 DK037963 to D. C. Eaton.
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NR 56
TC 10
Z9 13
U1 1
U2 9
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 1040-0605
EI 1522-1504
J9 AM J PHYSIOL-LUNG C
JI Am. J. Physiol.-Lung Cell. Mol. Physiol.
PD JUN
PY 2014
VL 306
IS 11
BP L1026
EP L1035
DI 10.1152/ajplung.00287.2013
PG 10
WC Physiology; Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology; Respiratory System
GA AJ7SE
UT WOS:000337896600008
PM 24682449
OA Green Published
DA 2025-06-11
ER

PT J
AU Obara, A
   Kamiya, T
   Izumi, M
   Hara, H
   Yamada, H
   Adachi, T
AF Obara, Aya
   Kamiya, Tetsuro
   Izumi, Misato
   Hara, Hirokazu
   Yamada, Harutaka
   Adachi, Tetsuo
TI Extracellular-Superoxide Dismutase Expression in COS7 Cells Exposed to
   Cadmium Chloride
SO BIOLOGICAL & PHARMACEUTICAL BULLETIN
LA English
DT Article
DE extracellular-superoxide dismutase; cadmium chloride; reactive oxygen
   species; p38-mitogen-activated protein kinase
ID UNFOLDED PROTEIN RESPONSE; OXIDATIVE STRESS; EC-SOD;
   ENDOPLASMIC-RETICULUM; METABOLIC SYNDROME; INDUCED APOPTOSIS; COBALT
   CHLORIDE; KRUPPEL-LIKE; DEATH; PATHWAYS
AB Cadmium (Cd), an industrial and environmental pollutant, preferentially accumulates in the kidney, a major target for Cd-related toxicity. It has been reported that Cd exposure produces reactive oxygen species (ROS) and induces cytotoxicity. Extracellular-superoxide dismutase (EC-SOD) is an antioxidant enzyme that protects the cells from damaging effects of ROS; however, the effect of Cd on the expression of EC-SOD in COS7 cells remains unclear. In this study, exposure to cadmium chloride (CdCl2) enhanced intracellular ROS generation and induced COS7 cell death. Moreover, exposure to Cd decreased the expression of EC-SOD at mRNA and protein levels, but not of other SOD isozymes, copper-and zinc-containing SOD and manganese-containing SOD. The reduction of EC-SOD and cell viability was partially attenuated by pretreatment with an antioxidant, N-acetylcysteine. Further, we determined the involvement of p38-mitogen-activated protein kinase (p38-MAPK) in the reduction of EC-SOD. From these observations, p38-MAPK signaling cascades activated by ROS play a pivotal role in the reduction of EC-SOD, and it is concluded that the reduction of EC-SOD leads to a decrease in the resistance to oxidative stress of Cd-exposed COS7 cells.
C1 [Obara, Aya; Kamiya, Tetsuro; Izumi, Misato; Hara, Hirokazu; Adachi, Tetsuo] Gifu Pharmaceut Univ, Lab Clin Pharmaceut, Gifu 5011196, Japan.
   [Yamada, Harutaka] Aichi Med Univ, Nephrol & Rheumatol Div Internal Med, Aichi 4801195, Japan.
C3 Gifu Pharmaceutical University; Aichi Medical University
RP Kamiya, T (corresponding author), Gifu Pharmaceut Univ, Lab Clin Pharmaceut, 1-25-4 Daigaku Nishi, Gifu 5011196, Japan.
EM tekamiya@gifu-pu.ac.jp
RI Kamiya, Tetsuro/AAY-7093-2021
FU Japan Society for the Promotion for Science [21790153, 21590169];
   Grants-in-Aid for Scientific Research [21790153, 21590169] Funding
   Source: KAKEN
FX This study was supported in part by a Grant-in-Aid for Scientific
   Research from the Japan Society for the Promotion for Science (to TK,
   No. 21790153 and TA, No. 21590169).
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TC 5
Z9 6
U1 0
U2 6
PU PHARMACEUTICAL SOC JAPAN
PI TOKYO
PA 2-12-15 SHIBUYA, SHIBUYA-KU, TOKYO, 150-0002, JAPAN
SN 0918-6158
J9 BIOL PHARM BULL
JI Biol. Pharm. Bull.
PD SEP
PY 2011
VL 34
IS 9
BP 1443
EP 1447
DI 10.1248/bpb.34.1443
PG 5
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 813SI
UT WOS:000294388500016
PM 21881231
OA Bronze
DA 2025-06-11
ER

PT J
AU Sicari, R
   Palinkas, A
   Pasanisi, EG
   Venneri, L
   Picano, E
AF Sicari, R
   Palinkas, A
   Pasanisi, EG
   Venneri, L
   Picano, E
TI Long-term survival of patients with chest pain syndrome and
   angiographically normal or near-normal coronary arteries: the additional
   prognostic value of dipyridamole echocardiography test (DET)
SO EUROPEAN HEART JOURNAL
LA English
DT Article
DE dipyridamole echocardio-graphy test (DET); prognosis; normal coronary
   artery
ID LEFT-VENTRICULAR HYPERTROPHY; CARDIAC SYNDROME-X; FOLLOW-UP; STRESS
   ECHOCARDIOGRAPHY; MYOCARDIAL-ISCHEMIA; DOBUTAMINE-STRESS; CLINICAL
   COURSE; ANGINAL SYNDROME; NATURAL-HISTORY; ARTERIOGRAMS
AB Aims Patients with normal coronary arteries have a heterogeneous prognosis. Aim of this study was to assess whether dipyridamole stress echocardiography positivity identifies a prognostically less benign subset.
   Methods and results We selected 457 patients (245 males; 56 +/- 10 years) who underwent stress high-dose dipyridamole echocardiography and had angiographically non-significant (< 50% visually assessed) stenosis in any major vessel and preserved left ventricular function. All patients were followed up for a median of 7.1 years (first quartile 5 and third quartile 10.5). Dipyridamole echocardiography test (DET) positivity for regional dysfunction occurred in 43(9%) patients. Kaplan-Meier survival estimates showed a significant better outcome for those patients with negative dipyridamole echocardiography test compared with those with a positive test (90 vs. 75.7%, at 140 months of follow-up, P=0.0018). At multivariable analysis, mild or moderate irregularity on coronary arteriogram (HR=3.3, CI 95%=1.7-6.2), diabetes (HR=3.5, CI 95%=1.4-9.2), and wall motion score index at peak stress (HR=6.7, CI 95%=2.5-17.8) were independent predictors of all-cause death.
   Conclusion DET adds incremental value to the prognostic stratification achieved with clinical and angiographic data in the subset of patients with normal or near-normal coronary arteries.
C1 CNR, Inst Clin Physiol, I-56123 Pisa, Italy.
   Elisabeth Hosp, Dept Internal Med, Hodmezovasarhely, Hungary.
C3 Consiglio Nazionale delle Ricerche (CNR); Istituto di Fisiologia Clinica
   (IFC-CNR)
RP CNR, Inst Clin Physiol, Via G Moruzzi 1, I-56123 Pisa, Italy.
EM rosas@ifc.cnr.it
RI Picano, E/G-2261-2014; Pasanisi, Emilio/AAB-3635-2019
OI pasanisi, emilio/0000-0001-8067-1178; Palinkas,
   Attila/0000-0003-4839-7150
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NR 47
TC 42
Z9 44
U1 0
U2 1
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0195-668X
EI 1522-9645
J9 EUR HEART J
JI Eur. Heart J.
PD OCT
PY 2005
VL 26
IS 20
BP 2136
EP 2141
DI 10.1093/eurheartj/ehi408
PG 6
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 970AV
UT WOS:000232278500013
PM 16014645
OA Bronze
DA 2025-06-11
ER

PT J
AU Sarapultsev, PA
   Sarapultsev, AP
AF Sarapultsev, Petr A.
   Sarapultsev, Alexey P.
TI Stress cardiomyopathy: Is it limited to Takotsubo syndrome? Problems of
   definition
SO INTERNATIONAL JOURNAL OF CARDIOLOGY
LA English
DT Review
DE Takotsubo; Stress cardiomyopathy; Variant angina; Microvascular angina;
   Pathophysiological mechanisms
ID CORONARY-ARTERY SPASM; APICAL BALLOONING SYNDROME; TAKO-TSUBO
   CARDIOMYOPATHY; CELL DISTRIBUTION WIDTH; CARDIAC SYNDROME-X;
   ENDOTHELIUM-DEPENDENT VASODILATION; OUTFLOW TRACT OBSTRUCTION; OXIDE
   SYNTHASE GENE; C-REACTIVE PROTEIN; ADRENERGIC-RECEPTOR POLYMORPHISMS
AB In 2006, Takotsubo syndrome (TTC) was described as a distinct type of stress-induced cardiomyopathy (stress cardiomyopathy). However, when thinking about Takotsubo cardiomyopathy from the viewpoints of the AHA and ESC classifications, 2 possible problems may arise.
   The first potential problem is that a forecast of disease outcome is lacking in the ESC classification, whereas the AHA only states that 'outcome is favorable with appropriate medical therapy'. However, based on the literature data, one can make a general conclusion that occurrence of myocardial lesions in TTC (i.e., myocardial fibrosis and contraction-band necrosis) causes the same effects as in other diseases with similar levels of myocardial damage and should not be considered to have a lesser impact on mortality. To summarise, TTC can cause not only severe complications such as pulmonary oedema, cardiogenic shock, and dangerous ventricular arrhythmias, but also damage to the myocardium, which can result in the development of potentially fatal conditions even after the disappearance of LV apical ballooning.
   The second potential problem arises from the definition of TTC as a stress cardiomyopathy in the AHA classification. In fact, the main factors leading to TTC are stress and microvascular anginas, since, as has been already discussed, coronary spasm can cause myocardium stunning, resulting in persistent apical ballooning. Thus, based on this review, 3 distinct types of stress cardiomyopathies exist (variant angina, microvascular angina, and TTC), with poor prognosis. Adding these diseases to the classification of cardiomyopathies will facilitate diagnosis and preventive prolonged treatment, which should include intensive anti-stress therapy. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
C1 [Sarapultsev, Alexey P.] Ural Fed Univ, Fed State Autonomous Educ Inst Higher Profess Edu, Ekaterinburg, Sverdlovsk Obla, Russia.
   RAS, Ural Branch, Inst Immunol & Physiol, Moscow, Russia.
C3 Ural Federal University; Russian Academy of Sciences; Institute of
   Immunology & Physiology UB RAS
RP Sarapultsev, AP (corresponding author), Ural Fed Univ, Fed State Autonomous Educ Inst Higher Profess Edu, Ekaterinburg, Sverdlovsk Obla, Russia.
EM a.sarapultsev@gmail.com
RI Sarapultsev, Alexey/K-7220-2012; Sarapultsev, Petr/M-8942-2019
OI Sarapultsev, Alexey/0000-0003-3101-9655
FU Ural Branch of RAS [16-15-3-4-27]; Act 211 of the Government of Russian
   Federation [02.A03.21.0006]
FX The authors declare no conflict of interest. The study was supported by
   Ural Branch of RAS, research project No. 16-15-3-4-27.Partly the study
   was supported by the Act 211 of the Government of Russian Federation,
   contract No 02.A03.21.0006.
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NR 347
TC 6
Z9 6
U1 0
U2 14
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
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SN 0167-5273
EI 1874-1754
J9 INT J CARDIOL
JI Int. J. Cardiol.
PD OCT 15
PY 2016
VL 221
BP 698
EP 718
DI 10.1016/j.ijcard.2016.07.030
PG 21
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA DX9DA
UT WOS:000384692600136
PM 27424315
DA 2025-06-11
ER

PT J
AU Polito, L
   Bortolotti, M
   Battelli, MG
   Bolognesi, A
AF Polito, Letizia
   Bortolotti, Massimo
   Battelli, Maria Giulia
   Bolognesi, Andrea
TI Chronic kidney disease: Which role for xanthine oxidoreductase activity
   and products?
SO PHARMACOLOGICAL RESEARCH
LA English
DT Review
DE Chronic kidney disease; Hypertension; Hyperuricemia; Nitric oxide;
   Reactive oxygen species; Xanthine oxidoreductase
ID SERUM URIC-ACID; OXIDATIVE STRESS; VASCULAR STIFFNESS; BLOOD-PRESSURE;
   HEART-FAILURE; HYPERURICEMIA; OXIDASE; CANCER; OXYGEN; HYPERTENSION
AB The present review explores the role of xanthine oxidoreductase (XOR) in the development and progression of chronic kidney disease (CKD). Human XOR is a multi-level regulated enzyme, which has many physiological functions, but that is also implicated in several pathological processes. The main XOR activities are the purine catabolism, which generates uric acid, and the regulation of cell redox state and cell signaling, through the production of reactive oxygen species. XOR dysregulation may lead to hyperuricemia and oxidative stress, which could have a pathogenic role in the initial phases of CKD, by promoting cell injury, hypertension, chronic inflammation and metabolic derangements. Hypertension is common in CKD patients and many mechanisms inducing it (upregulation of renin-angiotensin-aldosterone system, endothelial dysfunction and atherosclerosis) may be influenced by XOR products. High XOR activity and hyperuricemia are also risk factors for obesity, insulin resistance, type 2 diabetes and metabolic syndrome that are frequent CKD causes. Moreover, CKD is common in patients with gout, which is characterized by hyperuricemia, and in patients with cardiovascular diseases, which are associated with hypertension, endothelial dysfunction and atherosclerosis. Although hyperuricemia is undoubtedly related to CKD, controversial findings have been hitherto reported in patients treated with urate-lowering therapies.
C1 [Polito, Letizia; Bortolotti, Massimo; Battelli, Maria Giulia; Bolognesi, Andrea] Univ Bologna, Dept Expt Diagnost & Specialty Med DIMES, Alma Mater Studiorum, Via San Giacomo 14, I-40126 Bologna, Italy.
C3 University of Bologna
RP Polito, L; Bolognesi, A (corresponding author), Univ Bologna, Dept Expt Diagnost & Specialty Med DIMES, Alma Mater Studiorum, Via San Giacomo 14, I-40126 Bologna, Italy.
EM letizia.polito@unibo.it; andrea.bolognesi@unibo.it
RI Bolognesi, Andrea/Q-6526-2017; Battelli, Maria Giulia/G-2711-2015;
   BORTOLOTTI, MASSIMO/E-1822-2011; Polito, Letizia/H-2877-2019
OI Battelli, Maria Giulia/0000-0001-6048-0454; BORTOLOTTI,
   MASSIMO/0000-0001-9030-2237; Bolognesi, Andrea/0000-0001-7497-4586;
   Polito, Letizia/0000-0001-8051-4981
FU Alma Mater Studiorum -University of Bologna; Pallotti Legacies for
   Cancer Research
FX [This work was supported by funds for selected research topics from the
   Alma Mater Studiorum -University of Bologna and by the Pallotti Legacies
   for Cancer Research.
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NR 88
TC 29
Z9 31
U1 4
U2 19
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 1043-6618
EI 1096-1186
J9 PHARMACOL RES
JI Pharmacol. Res.
PD OCT
PY 2022
VL 184
AR 106407
DI 10.1016/j.phrs.2022.106407
EA AUG 2022
PG 9
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 6E1UP
UT WOS:000883169600005
PM 35995347
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Arjunan, A
   Sah, DK
   Jung, YD
   Song, J
AF Arjunan, Archana
   Sah, Dhiraj Kumar
   Jung, Young Do
   Song, Juhyun
TI Hepatic Encephalopathy and Melatonin
SO ANTIOXIDANTS
LA English
DT Review
DE melatonin; hepatic encephalopathy; hyperammonemia; neurotransmitter;
   neuroinflammation; cognitive impairment
ID POSTSYNAPTIC DENSITY-95 PSD-95; BRAIN-BARRIER PERMEABILITY; HUMAN
   CEREBRAL-CORTEX; OXIDATIVE STRESS; GLUTAMATE EXCITOTOXICITY;
   BENZODIAZEPINE-RECEPTORS; SIGNALING PATHWAY; BASAL GANGLIA; IN-VIVO; TAU
   HYPERPHOSPHORYLATION
AB Hepatic encephalopathy (HE) is a severe metabolic syndrome linked with acute/chronic hepatic disorders. HE is also a pernicious neuropsychiatric complication associated with cognitive decline, coma, and death. Limited therapies are available to treat HE, which is formidable to oversee in the clinic. Thus, determining a novel therapeutic approach is essential. The pathogenesis of HE has not been well established. According to various scientific reports, neuropathological symptoms arise due to excessive accumulation of ammonia, which is transported to the brain via the blood-brain barrier (BBB), triggering oxidative stress and inflammation, and disturbing neuronal-glial functions. The treatment of HE involves eliminating hyperammonemia by enhancing the ammonia scavenging mechanism in systemic blood circulation. Melatonin is the sole endogenous hormone linked with HE. Melatonin as a neurohormone is a potent antioxidant that is primarily synthesized and released by the brain's pineal gland. Several HE and liver cirrhosis clinical studies have demonstrated impaired synthesis, secretion of melatonin, and circadian patterns. Melatonin can cross the BBB and is involved in various neuroprotective actions on the HE brain. Hence, we aim to elucidate how HE impairs brain functions, and elucidate the precise molecular mechanism of melatonin that reverses the HE effects on the central nervous system.
C1 [Arjunan, Archana; Song, Juhyun] Chonnam Natl Univ, Dept Anat, Med Sch, Hwasun 58128, South Korea.
   [Sah, Dhiraj Kumar; Jung, Young Do] Chonnam Natl Univ, Dept Biochem, Med Sch, Hwasun 58128, South Korea.
   [Song, Juhyun] Chonnam Natl Univ, BioMed Sci Grad Program BMSGP, 264 Seoyangro, Hwasun 58128, South Korea.
C3 Chonnam National University; Chonnam National University; Chonnam
   National University
RP Song, J (corresponding author), Chonnam Natl Univ, Dept Anat, Med Sch, Hwasun 58128, South Korea.; Jung, YD (corresponding author), Chonnam Natl Univ, Dept Biochem, Med Sch, Hwasun 58128, South Korea.; Song, J (corresponding author), Chonnam Natl Univ, BioMed Sci Grad Program BMSGP, 264 Seoyangro, Hwasun 58128, South Korea.
EM archanaibms@gmail.com; 197784@chonnam.edu; ydjung@chonnam.ac.kr;
   juhyunsong@chonnam.ac.kr
RI Song, Juhyun/AAH-3162-2020
OI ARJUNAN, ARCHANA/0000-0001-7947-2614; SAH, DHIRAJ
   KUMAR/0000-0003-1857-6887; Song, Juhyun/0000-0002-9165-8507
FU National Research Foundation of Korea (NRF), Republic of Korea
   [2022R1A2C1006125]; Basic Science Research Program grant through the
   National Research Foundation of Korea - Ministry of Education, Science,
   and Technology [2018R1D1A1B07049918]
FX This study was supported and funded by the grant 2022R1A2C1006125
   (Juhyun Song) from the National Research Foundation of Korea (NRF),
   Republic of Korea. Moreover, this study was supported by the Basic
   Science Research Program grant through the National Research Foundation
   of Korea funded by the Ministry of Education, Science, and Technology
   grant 2018R1D1A1B07049918 (Young Do Jung).
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NR 205
TC 8
Z9 8
U1 0
U2 10
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD MAY
PY 2022
VL 11
IS 5
AR 837
DI 10.3390/antiox11050837
PG 20
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA 1R4CT
UT WOS:000803319500001
PM 35624703
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Ahmed, H
   Umar, MI
   Imran, S
   Javaid, F
   Syed, SK
   Riaz, R
   Hassan, W
AF Ahmed, Hammad
   Umar, Muhammad Ihtisham
   Imran, Salman
   Javaid, Faraza
   Syed, Shahzada Khurram
   Riaz, Romana
   Hassan, Waseem
TI TGF-β1 signaling can worsen NAFLD with liver fibrosis backdrop
SO EXPERIMENTAL AND MOLECULAR PATHOLOGY
LA English
DT Review
DE Non-alcoholic fatty liver disease; Oxidative stress; Pathogenesis;
   Reactive oxygen species; Treatment
ID GROWTH-FACTOR-BETA; STELLATE CELL ACTIVATION; TGF-BETA; METABOLIC
   SYNDROME; NONALCOHOLIC STEATOHEPATITIS; THERAPEUTIC TARGET; HEPATIC
   EXPRESSION; RAT MODEL; DISEASE; OBESITY
AB Non-Alcoholic Fatty Liver Disease (NAFLD) is characterized by the accumulation of fats in the liver. Relatively benign NAFLD often progresses to fibrosis, cirrhosis, and liver malignancies. Although NAFLD precedes fibrosis, continuous lipid overload keeps fueling fibrosis and the process of disease progression remains unhindered. It is well known that TGF-beta 1 plays its part in liver fibrosis, yet its effects on liver lipid overload remain unknown. As TGF-beta 1 signaling has been increasingly attempted to manage liver fibrosis, its actions on the primary suspect (NAFLD) are easily ignored. The complex interaction of inflammatory stress and lipid accumulation aided by mediators scuh as pro-inflammatory interleukins and TGF-beta 1 forms the basis of NAFLD progression. Anticipatorily, the inhibition of TGF-beta 1 signaling during anti-fibrotic treatment should reverse the NAFLD though the data remain scattered on this subject to date. TGF-beta 1 signaling pathway is an important drug target in liver fibrosis and abundant literature is available on it, but its direct effects on NAFLD are rarely studied. This review aims to cover the pathogenesis of NAFLD focusing on the role of the TGF-beta 1 in the disease progression, especially in the backdrop of liver fibrosis.
C1 [Ahmed, Hammad; Imran, Salman] Sialkot Med Coll, Dept Pharmacol, Sialkot, Pakistan.
   [Ahmed, Hammad; Imran, Salman] Imran Idrees Coll Pharm, Sialkot, Pakistan.
   [Umar, Muhammad Ihtisham; Hassan, Waseem] COMSATS Univ Islamabad, Dept Pharm, Lahore Campus, Lahore 54000, Pakistan.
   [Javaid, Faraza] Islamia Univ Bahawalpur, Dept Pharmacol, Bahawalpur, Pakistan.
   [Syed, Shahzada Khurram] Univ Management & Technol, Sch Hlth Sci, Dept Basic Med Sci, Lahore, Pakistan.
   [Riaz, Romana] Bakhtawar Amin Coll Pharmaceut Sci, Dept Pharmaceut, Multan, Pakistan.
   [Riaz, Romana] Bahauddin Zakariya Univ, Fac Pharm, Dept Pharmaceut, Multan, Pakistan.
C3 COMSATS University Islamabad (CUI); Islamia University of Bahawalpur;
   University of Management & Technology (UMT); Bahauddin Zakariya
   University
RP Hassan, W (corresponding author), COMSATS Univ Islamabad, Dept Pharm, Lahore Campus, Lahore 54000, Pakistan.
EM waseemhassan2010@yahoo.com
RI Ahmed, Hammad/AAW-8989-2020; Syed, ShahzadaKhurram/KII-4623-2024;
   Hassan, Waseem/AAD-1170-2019; Iqbal, Prof Dr Muhammad
   Shahid/AIB-1390-2022
OI Syed, shahzada Khurram/0000-0002-9412-9897; Ahmed,
   Hammad/0000-0001-5433-9155; Hassan, Waseem/0000-0002-0197-1736
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TC 32
Z9 34
U1 1
U2 28
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0014-4800
EI 1096-0945
J9 EXP MOL PATHOL
JI Exp. Mol. Pathol.
PD FEB
PY 2022
VL 124
AR 104733
DI 10.1016/j.yexmp.2021.104733
EA DEC 2021
PG 6
WC Pathology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pathology
GA YD7LK
UT WOS:000740619100005
PM 34914973
DA 2025-06-11
ER

PT J
AU Azirak, S
   Bilgic, S
   Korkmaz, DT
   Guvenc, AN
   Kocaman, N
   Ozer, MK
AF Azirak, Sebile
   Bilgic, Sedat
   Korkmaz, Deniz Tastemir
   Guvenc, Ayse N.
   Kocaman, Nevin
   Ozer, Mehmet K.
TI The protective effect of resveratrol against risperidone-induced liver
   damage through an action on FAS gene expression
SO GENERAL PHYSIOLOGY AND BIOPHYSICS
LA English
DT Article
DE Risperidone; Resveratrol; Fatty acid synthase; Liver; Apoptosis
ID FATTY-ACID SYNTHASE; INDUCED WEIGHT-GAIN; ANTIPSYCHOTIC TREATMENT;
   METABOLIC SYNDROME; OXIDATIVE STRESS; MICE; LIPOGENESIS; STEATOSIS;
   INCREASE; IMPROVES
AB The purpose of the study is to examine the protective effect of resveratrol on the fatty acid synthase gene expression against the side-effects of risperidone in an experimental model in rat liver. In this study, thirty-five female Spraque-Dawley rats were divided into five groups (n = 7): Control, RIS (2 mg/kg risperidone daily), RSV1 (2 mg/kg risperidone + 20 mg/kg resveratrol), RSV2 (2 mg/kg risperidone + 40 mg/kg resveratrol), and RSV3 group (2 mg/kg risperidone + 80 mg/kg resveratrol). On treatment day 15, liver tissue was taken for analysis. The resveratrol treatment significantly reduced weight gain as opposed to the risperidone administration. Moreover, the fatty acid synthase gene expression level increased significantly in RSV1 group (p = 0.011). In addition, resveratrol enhanced the total antioxidant status, high-density lipoprotein cholesterol levels and decreased alanine aminotransferase, aspartate aminotransferase, total cholesterol, gamma glutamyl transpeptidase, low density lipoprotein cholesterol, oxidative stress index, triglycerides, and total oxidant status levels significantly (p < 0.05). In conclusion, this study revealed that treatment with resveratrol might protect liver tissue against the side-effects of risperidone over fatty acid synthase gene expression. Resveratrol could be an effective course of therapy for enhancing therapeutic efficacy.
C1 [Azirak, Sebile; Bilgic, Sedat; Korkmaz, Deniz Tastemir; Guvenc, Ayse N.] Adiyaman Univ, Vocat Sch Hlth Serv, Adiyaman, Turkey.
   [Kocaman, Nevin] Firat Univ, Fac Med, Dept Histol, Elazig, Turkey.
   [Ozer, Mehmet K.] Adiyaman Univ, Fac Med, Dept Pharmacol, Adiyaman, Turkey.
C3 Adiyaman University; Firat University; Adiyaman University
RP Azirak, S (corresponding author), Adiyaman Univ, Vocat Sch Hlth Serv, Adiyaman, Turkey.
EM sazirak@adiyaman.edu.tr
RI Taştemir Korkmaz, Deniz/AAG-6736-2019; bilgiç, sedat/JVN-5459-2024;
   KOCAMAN, NEVIN/V-9730-2018; AZIRAK, Sebile/HPC-1239-2023
OI Bilgic, Sedat/0000-0001-8410-2685
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NR 40
TC 10
Z9 10
U1 0
U2 8
PU GENERAL PHYSIOL AND BIOPHYSICS
PI BRATISLAVA
PA INST OF MOLEC PHYSIOL GENETICS SLOVAK ACAD OF SCI VLARSKA 5, 83334
   BRATISLAVA, SLOVAKIA
SN 0231-5882
EI 1338-4325
J9 GEN PHYSIOL BIOPHYS
JI Gen. Physiol. Biophys.
PY 2019
VL 38
IS 3
BP 215
EP 225
DI 10.4149/gpb_2018045
PG 11
WC Biochemistry & Molecular Biology; Biophysics; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Physiology
GA IC7NN
UT WOS:000471161600003
PM 31184308
OA gold
DA 2025-06-11
ER

PT J
AU Jia, YF
   Feng, Q
   Ge, ZY
   Guo, Y
   Zhou, F
   Zhang, KS
   Wang, XW
   Lu, WH
   Liang, XW
   Gu, YQ
AF Jia, Yan-Fei
   Feng, Qian
   Ge, Zheng-Yan
   Guo, Ying
   Zhou, Fang
   Zhang, Kai-Shu
   Wang, Xiao-Wei
   Lu, Wen-Hong
   Liang, Xiao-Wei
   Gu, Yi-Qun
TI Obesity impairs male fertility through long- term effects on
   spermatogenesis
SO BMC UROLOGY
LA English
DT Article
DE Obesity; Spermatogenesis; Sex hormone-binding globulin; Testosterone
ID BODY-MASS INDEX; TESTICULAR FUNCTION; INSULIN-RESISTANCE; METABOLIC
   SYNDROME; MALE-INFERTILITY; INCREASED RISK; SEMEN QUALITY; STRESS; MEN;
   TESTOSTERONE
AB Objective: This study aimed to investigate the effect and possible underlying mechanisms of high fat diet induced obesity on spermatogenesis in male rats.
   Methods: A total of 45 male rats were randomly divided into control (n = 15, normal diet) and obesity groups (n = 30, high fat diet) and were fed for 16 weeks Body weight and organ indexes were determined after sacrifice indicators of reproductive function, including sperm count, sperm motility, apoptosis of spermatogenic cells, and oxidative stress levels, were measured Serum metabolic parameters and reproductive hormones were also assayed.
   Results: Compared with the control group, epididymal sperm motility in the obese rats was significantly decreased (P< 0. 01) Morphological analysis of the obesity group showed vacuolar changes in seminiferous tubules, spermatogenic ceil dysfunction, and increased apoptosis of spermatogenic cells in testicular tissue (P< 0.05) The calculated free testosterone (cFT) concentration in serum was decreased (P< 0.05), whereas the serum sex hormone binding globulin (SHBG) level was significantly increased (P < 0.01) The superoxide dismutase (SOD) concentration decreased and the malondialdehyde (MDA) concentration increased in testis tissues, however, neither changes were statistically significant (P >0.05).
   Results: Nutritional obesity can damage spermatogenesis in male rats due to long term effects on spermatogenesis.
C1 [Jia, Yan-Fei; Feng, Qian] Lanzhou Univ, Hosp 2, Lanzhou 730020, Gansu, Peoples R China.
   [Ge, Zheng-Yan] Xiyuan Hosp, China Acad Tradit Chinese Med, Beijing 100091, Peoples R China.
   [Guo, Ying; Zhou, Fang; Zhang, Kai-Shu; Gu, Yi-Qun] Peking Union Med Coll, Grad Sch, 9 Dongdansantiao, Beijing 100730, Peoples R China.
   [Guo, Ying; Zhou, Fang; Zhang, Kai-Shu; Wang, Xiao-Wei; Lu, Wen-Hong; Liang, Xiao-Wei; Gu, Yi-Qun] Natl Res Inst Family Planning, Dept Male Clin Res, Natl Hlth & Family Planning Key Lab Male Reprod H, Beijing 100081, Peoples R China.
C3 Lanzhou University; China Academy of Chinese Medical Sciences; Xiyuan
   Hospital, CACMS; Chinese Academy of Medical Sciences - Peking Union
   Medical College; Peking Union Medical College; National Research
   Institute for Family Planning - China
RP Gu, YQ (corresponding author), Peking Union Med Coll, Grad Sch, 9 Dongdansantiao, Beijing 100730, Peoples R China.; Gu, YQ (corresponding author), Natl Res Inst Family Planning, Dept Male Clin Res, Natl Hlth & Family Planning Key Lab Male Reprod H, Beijing 100081, Peoples R China.
EM yqgu90@126.com
RI Wang, Xiaowei/JDC-4332-2023
FU  [2012BAI32B03]
FX This work was financed by the National "Twelfth Five-Year" Plan for
   Science and Technology Support (2012BAI32B03 for purchasing most of the
   experimental reagents and materials, as well as the labor costs for the
   researchers and the fee for some antibodies).
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NR 40
TC 66
Z9 72
U1 0
U2 21
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1471-2490
J9 BMC UROL
JI BMC Urol.
PD MAY 16
PY 2018
VL 18
AR 42
DI 10.1186/s12894-018-0360-5
PG 8
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA GG8JM
UT WOS:000432943600001
PM 29769123
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Braakhuis, AJ
   Nagulan, R
   Somerville, V
AF Braakhuis, Andrea J.
   Nagulan, Rohith
   Somerville, Vaughan
TI The Effect of MitoQ on Aging-Related Biomarkers: A Systematic Review and
   Meta-Analysis
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Review
ID MITOCHONDRIA-TARGETED ANTIOXIDANT; DIET-FED RATS; OXIDATIVE STRESS;
   METABOLIC SYNDROME; SKELETAL-MUSCLE; MOUSE MODEL; LIFE-SPAN; IN-VIVO;
   DISEASE; DYSFUNCTION
AB Mitochondria are metabolically active organelles that produce significant reactive oxygen species, linked with aging and degenerative diseases. In recent years, particular focus has been put on mitochondria-targeted antioxidants, to decrease the concentration of reactive oxygen species and help alleviate the accumulation of oxidative damage and associated aging. MitoQ is a mitochondria-targeted antioxidant of which is reported to support healthy aging. The aim of this systematic review is to investigate the effects of MitoQ on oxidative outcomes related to the aging process. A predeveloped search strategy was run against MEDLINE (Ovid), EMBASE (Ovid), and CINAHL databases, which identified 10,255 articles of interest, with 27 of these finalised for use after screening. Three outcomes had sufficient data to meta-analyse nitrotyrosine concentration (190 animals, SMD -0.67, 95% CI (-1.30, -0.05), p = 0 04), membrane potential (63 animals, MD 11.44, 95% CI (1.28-21.60), p = 0 03), and protein carbonyl concentration (182 animals, SMD -0.13, 95% CI (-0.44, 0.18), p = 0 41). MitoQ intervention produced a statistically significant reduction in nitrotyrosine concentration and increased membrane potential. MitoQ may be of some benefit in alleviating oxidative stress related to aging.
C1 [Braakhuis, Andrea J.; Nagulan, Rohith; Somerville, Vaughan] Univ Auckland, Fac Med & Hlth Sci, Discipline Nutr, Private Bag 92019, Auckland, New Zealand.
C3 University of Auckland
RP Braakhuis, AJ (corresponding author), Univ Auckland, Fac Med & Hlth Sci, Discipline Nutr, Private Bag 92019, Auckland, New Zealand.
EM a.braakhuis@auckland.ac.nz
RI Braakhuis, Andrea/AEW-9971-2022
OI Somerville, Vaughan/0000-0002-1980-4135; Braakhuis,
   Andrea/0000-0002-6055-0595
FU University of Auckland Faculty of Medical and Health Science; Antipodean
   Pharmaceuticals [36462.001]
FX This work was supported by The University of Auckland Faculty of Medical
   and Health Science summer research grant and uniservices commercial
   grant, supported by the Antipodean Pharmaceuticals (Grant no.
   36462.001). Contractually, the authors were supported to publish the
   outcomes regardless of the findings.
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NR 46
TC 31
Z9 31
U1 0
U2 2
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PY 2018
VL 2018
AR 8575263
DI 10.1155/2018/8575263
PG 12
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA GO2IP
UT WOS:000439793600001
PM 30116495
OA Green Published, hybrid, Green Submitted
DA 2025-06-11
ER

PT J
AU Ludtmann, MHR
   Angelova, PR
   Zhang, Y
   Abramov, AY
   Dinkova-Kostova, AT
AF Ludtmann, Marthe H. R.
   Angelova, Plamena R.
   Zhang, Ying
   Abramov, Andrey Y.
   Dinkova-Kostova, Albena T.
TI Nrf2 affects the efficiency of mitochondrial fatty acid oxidation
SO BIOCHEMICAL JOURNAL
LA English
DT Article
DE ATP; FAD; fatty acid oxidation; Kelch-like ECH-associated protein 1
   (Keap1); live-cell imaging; tissue slice
ID TRANSCRIPTION FACTOR NRF2; ANTIOXIDANT RESPONSE; GENE-EXPRESSION;
   OLIGONUCLEOTIDE MICROARRAY; CELLULAR DEFENSE; LIPID-METABOLISM; MICE;
   INDUCTION; CANCER; STRESS
AB Transcription factor Nrf2 (NF-E2 p45-related factor 2) regulates the cellular redox homoeostasis and cytoprotective responses, allowing adaptation and survival under conditions of stress. The significance of Nrf2 in intermediary metabolism is also beginning to be recognized. Thus this transcription factor negatively affects fatty acid synthesis. However, the effect of Nrf2 on fatty acid oxidation is currently unknown. In the present paper, we report that the mitochondrial oxidation of long-chain (palmitic) and short-chain (hexanoic) fatty acids is depressed in the absence of Nrf2 and accelerated when Nrf2 is constitutively active. Addition of fatty acids stimulates respiration in heart and liver mitochondria isolated from wild-type mice. This effect is significantly weaker when Nrf2 is deleted, whereas it is stronger when Nrf2 activity is constitutively high. In the absence of glucose, addition of fatty acids differentially affects the production of ATP in mouse embryonic fibroblasts from wild-type, Nrf2-knockout and Keap1 (Kelch-like ECH-associated protein 1)-knockout mice. In acute tissue slices, the rate of regeneration of FADH(2) is reduced when Nrf2 is absent. This metabolic role of Nrf2 on fatty acid oxidation has implications for chronic disease conditions including cancer, metabolic syndrome and neurodegeneration.
C1 [Ludtmann, Marthe H. R.; Angelova, Plamena R.; Abramov, Andrey Y.] UCL, Inst Neurol, Dept Mol Neurosci, London WC1N 3BG, England.
   [Zhang, Ying; Dinkova-Kostova, Albena T.] Univ Dundee, Div Canc Res, Jacqui Wood Canc Ctr, Med Res Inst, Dundee DD1 9SY, Scotland.
   [Dinkova-Kostova, Albena T.] Johns Hopkins Univ, Sch Med, Dept Pharmacol & Mol Sci, Baltimore, MD 21205 USA.
C3 University of London; University College London; University of Dundee;
   Johns Hopkins University
RP Abramov, AY (corresponding author), UCL, Inst Neurol, Dept Mol Neurosci, London WC1N 3BG, England.
EM a.abramov@ucl.ac.uk; a.dinkovakostova@dundee.ac.uk
RI Angelova, Plamena/K-4444-2013; Dinkova-Kostova, Albena/AEB-8168-2022;
   Abramov, Andrey/H-9053-2012; Ludtmann, Marthe/A-1446-2013
OI Abramov, Andrey/0000-0002-7646-7235; Ludtmann,
   Marthe/0000-0003-1051-6425; Dinkova-Kostova, Albena/0000-0003-0316-9859
FU Cancer Research UK [C20953/A10270]; Wellcome Trust/MRC Parkinson's
   Consortium Grant; MRC [MC_G1000735] Funding Source: UKRI
FX This work was supported by Cancer Research UK [grant number
   C20953/A10270] and the Wellcome Trust/MRC Parkinson's Consortium Grant.
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NR 41
TC 190
Z9 212
U1 3
U2 38
PU PORTLAND PRESS LTD
PI LONDON
PA THIRD FLOOR, EAGLE HOUSE, 16 PROCTER STREET, LONDON WC1V 6 NX, ENGLAND
SN 0264-6021
EI 1470-8728
J9 BIOCHEM J
JI Biochem. J.
PD FEB 1
PY 2014
VL 457
BP 415
EP 424
DI 10.1042/BJ20130863
PN 3
PG 10
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA AE1GP
UT WOS:000333718100005
PM 24206218
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Maher, JJ
AF Maher, Jacquelyn J.
TI New Insights from Rodent Models of Fatty Liver Disease
SO ANTIOXIDANTS & REDOX SIGNALING
LA English
DT Review
ID CHOLINE-DEFICIENT DIET; ENDOPLASMIC-RETICULUM STRESS; INDUCED HEPATIC
   STEATOSIS; NONALCOHOLIC STEATOHEPATITIS MODEL; CONSTITUTIVE ANDROSTANE
   RECEPTOR; SERUM ALANINE AMINOTRANSFERASE; ADIPONECTIN KNOCKOUT MICE;
   DE-NOVO LIPOGENESIS; PPAR-ALPHA AGONIST; INSULIN-RESISTANCE
AB Rodent models of fatty liver disease are essential research tools that provide a window into disease pathogenesis and a testing ground for prevention and treatment. Models come in many varieties involving dietary and genetic manipulations, and sometimes both. High-energy diets that induce obesity do not uniformly cause fatty liver disease; this has prompted close scrutiny of specific macronutrients and nutrient combinations to determine which have the greatest potential for hepatotoxicity. At the same time, diets that do not cause obesity or the metabolic syndrome but do cause severe steatohepatitis have been exploited to study factors important to progressive liver injury, including cell death, oxidative stress, and immune activation. Rodents with a genetic predisposition to overeating offer yet another model in which to explore the evolution of fatty liver disease. In some animals that overeat, steatohepatitis can develop even without resorting to a high-energy diet. Importantly, these models and others have been used to document that aerobic exercise can prevent or reduce fatty liver disease. This review focuses primarily on lessons learned about steatohepatitis from manipulations of diet and eating behavior. Numerous additional insights about hepatic lipid metabolism, which have been gained from genetically engineered mice, are also mentioned. Antioxid. Redox Signal. 15, 535-550.
C1 [Maher, Jacquelyn J.] Univ Calif San Francisco, Ctr Liver, San Francisco, CA 94143 USA.
   [Maher, Jacquelyn J.] Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA.
C3 University of California System; University of California San Francisco;
   University of California System; University of California San Francisco
RP Maher, JJ (corresponding author), San Francisco Gen Hosp, Liver Ctr Lab, 1001 Potrero Ave,Bldg 40,Room 4102, San Francisco, CA 94110 USA.
EM jmaher@medsfgh.ucsf.edu
FU NIH [R01 DK068450, P30 DK026743]; National Institute of Diabetes and
   Digestive and Kidney Diseases [P30DK026743] Funding Source: NIH RePORTER
FX This work was supported by NIH grants R01 DK068450 and P30 DK026743.
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NR 142
TC 40
Z9 46
U1 0
U2 8
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1523-0864
EI 1557-7716
J9 ANTIOXID REDOX SIGN
JI Antioxid. Redox Signal.
PD JUL 15
PY 2011
VL 15
IS 2
BP 535
EP 550
DI 10.1089/ars.2010.3749
PG 16
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 787FC
UT WOS:000292361000019
PM 21126212
OA Green Published, Green Accepted
DA 2025-06-11
ER

PT J
AU Braga, GD
   Simoes, JLB
   dos Santos, YJT
   Menta, JC
   Bagatini, MD
AF Braga, Georgia de Carvalho
   Simoes, Julia Lea Batista
   dos Santos, Yara Juarez Teixeira
   Menta Filho, Joa Carlos
   Bagatini, Margarete Dulce
TI The impacts of obesity in rheumatoid arthritis and insights into
   therapeutic purinergic modulation
SO INTERNATIONAL IMMUNOPHARMACOLOGY
LA English
DT Article
DE Rheumatoid arthritis; Obesity; Purinergic; Therapy
ID CHAIN FATTY-ACIDS; LOW-GRADE INFLAMMATION; GUT MICROBIOTA; OXIDATIVE
   STRESS; METABOLIC SYNDROME; LARGE-INTESTINE; ADIPOSE-TISSUE; DIETARY
   FIBER; P2X7 RECEPTOR; BODY-WEIGHT
AB Rheumatoid Arthritis (RA) is an autoimmune condition responsible for the impairment of synovia and joints, endangering the functionality of individuals and contributing to mortality. Currently, obesity is increasing worldwide, and recent studies have suggested an association between such condition and RA. In this sense, obese individuals present a lower capacity for achieving remission and present more intense symptoms of the disease, demonstrating a link between both disorders. Different studies aim to understand the possible connection between the conditions; however, few is known in this sense. Therefore, knowing that obesity can alter the activity of multiple body systems, this work 's objective is to evaluate the main modifications caused by obesity, which can be linked to the pathophysiology of RA, highlighting as relevant topics obesity 's negative impact triggering systemic inflammation, intestinal dysbiosis, endocrine disbalances. Furthermore, the relationship between oxidative stress and obesity also deserves to be highlighted, considering the influence of reactive oxygen species (ROS) accumulation in RA exacerbation. Additionally, many of those characteristics influenced by obesity, along with the classic peculiarities of RA pathophysiology, can also be associated with purinergic signaling. Hence, this work suggests possible connections between the purinergic system and RA, proposing potential therapeutic targets against RA to be studied.
C1 [Braga, Georgia de Carvalho; Simoes, Julia Lea Batista; dos Santos, Yara Juarez Teixeira; Menta Filho, Joa Carlos] Fed Univ Fronteira, Med Sch, Chapeco, SC, Brazil.
   [Bagatini, Margarete Dulce] Fed Univ Fronteira Sul, Grad Program Med Sci, Chapeco, SC, Brazil.
C3 Universidade Federal da Fronteira Sul
RP Bagatini, MD (corresponding author), Fed Univ Fronteira Sul, Grad Program Med Sci, Chapeco, SC, Brazil.
EM margaretebagatini@yahoo.com.br
RI ; Bagatini, Margarete/K-3756-2016
OI de Carvalho Braga, Georgia/0000-0003-0384-9934; Bagatini,
   Margarete/0000-0001-9263-4980; Simoes, Julia/0000-0002-1652-9692
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NR 189
TC 3
Z9 3
U1 0
U2 0
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1567-5769
EI 1878-1705
J9 INT IMMUNOPHARMACOL
JI Int. Immunopharmacol.
PD JUL 30
PY 2024
VL 136
AR 112357
DI 10.1016/j.intimp.2024.112357
EA MAY 2024
PG 13
WC Immunology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Pharmacology & Pharmacy
GA UG9R1
UT WOS:001247027000001
PM 38810303
DA 2025-06-11
ER

PT J
AU Rezvanfar, MA
   Saadi, HAS
   Gooshe, M
   Abdolghaffari, AH
   Baeeri, M
   Abdollahi, M
AF Rezvanfar, Mohammad Amin
   Saadi, Habib A. Shojaei
   Gooshe, Maziar
   Abdolghaffari, Amir Hosein
   Baeeri, Maryam
   Abdollahi, Mohammad
TI Ovarian Aging-Like Phenotype in the Hyperandrogenism-Induced Murine
   Model of Polycystic Ovary
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Article
ID GLYCATION END-PRODUCTS; OXIDATIVE STRESS; METABOLIC SYNDROME;
   GRANULOSA-CELLS; SYNDROME PCOS; MECHANISMS; SENESCENCE; EXPRESSION;
   PROTECTION; FOLLICLES
AB There are prominently similar symptoms, effectors, and commonalities in the majority of characteristics between ovarian aging and polycystic ovarian syndrome (PCOS). Despite the approved role of oxidative stress in the pathogenesis of PCOS and aging, to our knowledge, the link between the PCO(S) and aging has not been investigated yet. In this study we investigated the possible exhibition of ovarian aging phenotype in murine model of PCO induced by daily oral administration of letrozole (1 mg/kg body weight) for 21 consecutive days in the female Wistar rats. Hyperandrogenization showed irregular cycles and histopathological characteristics of PCO which was associated with a significant increase in lipid peroxidation (LPO) and reactive oxygen species (ROS) and decrease in total antioxidant capacity (TAC) in serum and ovary. Moreover, serum testosterone, insulin and tumor necrosis factor-alpha (TNF-alpha) levels, and ovarian matrix metalloproteinase-2 (MMP-2) were increased in PCO rats compared with healthy controls, while estradiol and progesterone diminished. Almost all of these findings are interestingly found to be common with the characteristics identified with (ovarian) aging showing that hyperandrogenism-induced PCO in rat is associated with ovarian aging-like phenotypes. To our knowledge, this is the first report that provides evidence regarding the phenomenon of aging in PCO.
C1 [Rezvanfar, Mohammad Amin; Abdollahi, Mohammad] Univ Tehran Med Sci, Dept Pharmacol & Toxicol, Fac Pharm, Tehran 1417614411, Iran.
   [Rezvanfar, Mohammad Amin; Baeeri, Maryam; Abdollahi, Mohammad] Univ Tehran Med Sci, Pharmaceut Sci Res Ctr, Tehran 1417614411, Iran.
   [Saadi, Habib A. Shojaei] Univ Laval, Ctr Rech Biol Reprod, Quebec City, PQ G1V 0A6, Canada.
   [Gooshe, Maziar] Univ Tehran Med Sci, Fac Med, Tehran 1417614411, Iran.
   [Abdolghaffari, Amir Hosein] Inst Med Plants, Pharmacol & Appl Med Dept, Med Plants Res Ctr, ACECR, Karaj 141554364, Alborz, Iran.
   [Abdolghaffari, Amir Hosein] Tehran Univ Med Sci ICTUMS, Tehran 1417653861, Iran.
C3 Tehran University of Medical Sciences; Tehran University of Medical
   Sciences; Laval University; Tehran University of Medical Sciences;
   Academic Center for Education, Culture & Research (ACECR)
RP Abdollahi, M (corresponding author), Univ Tehran Med Sci, Dept Pharmacol & Toxicol, Fac Pharm, Tehran 1417614411, Iran.
EM mohammad@tums.ac.ir
RI Abdolghaffari, Amir/AAQ-1161-2021; Saadi, Habib/U-6878-2019;
   /B-9232-2008; Rezvanfar, Mohammad Amin/Q-4912-2016; Shojaei Saadi, Habib
   A./H-2325-2013
OI Abdolghaffari, Amir Hossein/0000-0001-9961-9097; Baeeri,
   Maryam/0000-0002-5018-7438; /0000-0003-0123-1209; Rezvanfar, Mohammad
   Amin/0000-0001-9694-3457; Shojaei Saadi, Habib A./0000-0001-8043-4391
FU TUMS
FX The authors acknowledge partial support from TUMS.
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NR 51
TC 35
Z9 38
U1 1
U2 10
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PY 2014
VL 2014
AR 948951
DI 10.1155/2014/948951
PG 10
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA AC4PX
UT WOS:000332504300001
PM 24693338
OA gold, Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Anderson, JM
   Arnold, WD
   Huang, W
   Ray, A
   Owendoff, G
   Cao, L
AF Anderson, Jacqueline M.
   Arnold, W. David
   Huang, Wei
   Ray, Alissa
   Owendoff, Gregory
   Cao, Lei
TI Long-term effects of a fat-directed FGF21 gene therapy in aged female
   mice
SO GENE THERAPY
LA English
DT Article
ID ENERGY-EXPENDITURE; METABOLIC SYNDROME; ADIPOSE; GLUCOSE; MUSCLE;
   INFLAMMATION; HOMEOSTASIS; DELIVERY; ANXIETY; OBESITY
AB Fibroblast growth factor 21 (FGF21) has been developed as a potential therapeutic agent for metabolic syndromes. Moreover, FGF21 is considered a pro-longevity hormone because transgenic mice overexpressing FGF21 display extended lifespan, raising the possibility of using FGF21 to promote healthy aging. We recently showed that visceral fat directed FGF21 gene therapy improves metabolic and immune health in insulin resistant BTBR mice. Here, we used a fat directed rAAV-FGF21 vector in 17-month-old female mice to investigate whether long-term FGF21 gene transfer could mitigate aging-related functional decline. Animals with FGF21 treatment displayed a steady, significant lower body weight over 7-month of the study compared to age-matched control mice. FGF21 treatment reduced adiposity and increased relative lean mass and energy expenditure associated with almost 100 folds higher serum level of FGF21. However, those changes were not translated into benefits on muscle function and did not affect metabolic function of liver. Overall, we have demonstrated that a single dose of fat-directed AAV-FGF21 treatment can provide a sustainable, high serum level of FGF21 over long period of time, and mostly influences adipose tissue homeostasis and energy expenditure. High levels of FGF21 alone in aged mice is not sufficient to improve liver or muscle functions.
C1 [Anderson, Jacqueline M.; Huang, Wei; Cao, Lei] Ohio State Univ, Dept Canc Biol & Genet, Columbus, OH 43210 USA.
   [Anderson, Jacqueline M.; Huang, Wei; Cao, Lei] Ohio State Univ, Comprehens Canc Ctr, Columbus, OH 43210 USA.
   [Arnold, W. David] Univ Missouri, NextGen Precis Hlth, Columbia, MO USA.
   [Arnold, W. David] Univ Missouri, Dept Phys Med & Rehabil, Columbia, MO USA.
   [Ray, Alissa; Owendoff, Gregory] Ohio State Univ, Coll Med, Dept Neurol, Columbus, OH USA.
C3 University System of Ohio; Ohio State University; James Cancer Hospital
   & Solove Research Institute; University System of Ohio; Ohio State
   University; University of Missouri System; University of Missouri
   Columbia; University of Missouri System; University of Missouri
   Columbia; University System of Ohio; Ohio State University
RP Cao, L (corresponding author), Ohio State Univ, Dept Canc Biol & Genet, Columbus, OH 43210 USA.; Cao, L (corresponding author), Ohio State Univ, Comprehens Canc Ctr, Columbus, OH 43210 USA.
EM Lei.Cao@osumc.edu
RI Arnold, W./AAM-5649-2020; Cao, Lei/B-3254-2012
OI Owendoff, Gregory/0000-0003-4213-0367; wang, haoyu/0009-0001-2467-5331
FU NIH [AG041250, CA166590, CA163640]; Ohio State University Comprehensive
   Cancer Center
FX We thank the Comparative Pathology & Mouse Phenotyping Shared Resource
   at the Ohio State University's College of Veterinary Medicine and the
   Small Animal Imaging Core of The Dorothy M. Davis Heart & Lung Research
   Institute, The Ohio State University for their technical assistance.
   This work was supported by NIH grants AG041250, CA166590, and CA163640,
   as well as internal funding from The Ohio State University Comprehensive
   Cancer Center.
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NR 66
TC 2
Z9 2
U1 3
U2 18
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0969-7128
EI 1476-5462
J9 GENE THER
JI Gene Ther.
PD MAR
PY 2024
VL 31
IS 3-4
BP 95
EP 104
DI 10.1038/s41434-023-00422-0
EA SEP 2023
PG 10
WC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
   Genetics & Heredity; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
   Genetics & Heredity; Research & Experimental Medicine
GA KY4W4
UT WOS:001064518900001
PM 37699965
DA 2025-06-11
ER

PT J
AU Santamarina, AB
   Calder, PC
   Estadella, D
   Pisani, LP
AF Santamarina, Aline B.
   Calder, Philip C.
   Estadella, Debora
   Pisani, Luciana P.
TI Anthocyanins ameliorate obesity-associated metainflammation: Preclinical
   and clinical evidence
SO NUTRITION RESEARCH
LA English
DT Review
DE Bioactive compounds; Obesity; Oxidative stress; Polyphenols; Insulin
   resistance; TLR4; NF eB pathway; Gut microbiota
ID HIGH-FAT-DIET; ADIPOSE-TISSUE DYSFUNCTION; LOW-GRADE INFLAMMATION;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; GUT MICROBIOTA; METABOLIC
   SYNDROME; LIVER-DISEASE; WESTERN DIET; ACID
AB The growing rates of obesity worldwide call for intervention strategies to help control the pathophysiological consequences of weight gain. The use of natural foods and bioactive compounds has been suggested as such a strategy because of their recognized antioxidant and anti-inflammatory properties. For example, polyphenols, especially anthocyanins, are candidates for managing obesity and its related metabolic disorders. Obesity is well known for the presence of metainflammation, which has been labeled as an inflammatory acti-vation that leads to a variety of metabolic disorders, usually related to increased oxidative stress. Considering this, anthocyanins may be promising natural compounds able to mod-ulate several intracellular mechanisms, mitigating oxidative stress and metainflammation. A wide variety of foods and extracts rich in anthocyanins have become the focus of re-search in the field of obesity. Here, we bring together the current knowledge regarding the use of anthocyanins as an intervention tested in vitro, in vivo, and in clinical trials to mod-ulate metainflammation. Most recent research applies a wide variety of extracts and natu-ral sources of anthocyanins, in diverse experimental models, which represents a limitation of the research field. However, the literature is sufficiently consistent to establish that the in-depth molecular analysis of gut microbiota, insulin signaling, TLR4-triggered inflamma-tion, and oxidative stress pathways reveals their modulation by anthocyanins. These targets are interconnected at the cellular level and interact with one another, leading to obesity - associated metainflammation. Thus, the positive findings with anthocyanins observed in preclinical models might directly relate to the positive outcomes in clinical studies. In sum-mary and based on the entirety of the relevant literature, anthocyanins can mitigate obesity -related perturbations in gut microbiota, insulin resistance, oxidative stress and inflamma-tion and therefore may contribute as a therapeutic tool in people living with obesity. (c) 2023 Elsevier Inc. All rights reserved.
C1 [Santamarina, Aline B.; Estadella, Debora; Pisani, Luciana P.] Univ Fed Sao Paulo, Inst Hlth & Soc, Biosci Dept, Campus Baixada Santista UNIFESP, Santos, SP, Brazil.
   [Calder, Philip C.] Univ Southampton, Fac Med, Sch Human Dev & Hlth, Southampton, England.
   [Calder, Philip C.] Univ Hosp Southampton NHS Fdn Trust, NIHR Southampton Biomed Res Ctr, Southampton, England.
   [Calder, Philip C.] Univ Southampton, NIHR Southampton Biomed Res Ctr, Southampton, England.
   [Pisani, Luciana P.] Rua Silva Jardim 136, BR-11020015 Santos, SP, Brazil.
C3 Universidade Federal de Sao Paulo (UNIFESP); University of Southampton;
   University of Southampton; University Hospital Southampton NHS
   Foundation Trust; University of Southampton
RP Pisani, LP (corresponding author), Rua Silva Jardim 136, BR-11020015 Santos, SP, Brazil.
EM pisani@unifesp.br
RI Santamarina, Aline/AAI-7639-2020; Estadella, Debora/G-5817-2012; Pisani,
   Luciana/B-3038-2015; Calder, Philip/E-9739-2013
OI Calder, Philip/0000-0002-6038-710X; Pisani, Luciana/0000-0001-6579-6167
FU "Fundacao de Amparo a Pesquisa do Estado de Sao Paulo " (FAPESP)
   [2020/04448-0]; CNPq-Conselho Nacional de Desenvolvimento Cientifico e
   Tecnologico fellowship [305725/2020-3]
FX This work was supported by "Fundacao de Amparo a Pesquisa do Estado de
   Sao Paulo " (FAPESP 2020/04448-0) . L.P.P. receives a CNPq-Conselho
   Nacional de Desenvolvimento Cientifico e Tecnologico fellowship
   (305725/2020-3) .
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NR 164
TC 19
Z9 20
U1 3
U2 19
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0271-5317
EI 1879-0739
J9 NUTR RES
JI Nutr. Res.
PD JUN
PY 2023
VL 114
BP 50
EP 70
DI 10.1016/j.nutres.2023.04.004
EA MAY 2023
PG 21
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA I3RS9
UT WOS:001001990800001
PM 37201432
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Malakul, W
   Seenak, P
   Jumroon, N
   Arikit, S
   Kumphune, S
   Nernpermpisooth, N
AF Malakul, Wachirawadee
   Seenak, Porrnthanate
   Jumroon, Noppadon
   Arikit, Siwaret
   Kumphune, Sarawut
   Nernpermpisooth, Nitirut
TI Novel Coconut Vinegar Attenuates Hepatic and Vascular Oxidative Stress
   in Rats Fed a High-Cholesterol Diet
SO FRONTIERS IN NUTRITION
LA English
DT Article
DE coconut vinegar; dyslipidemia; hepatic oxidative stress; vascular
   oxidative stress; lipid peroxidation
ID FATTY LIVER-DISEASE; MEDICINE FOOD HOMOLOGY; SUBCLINICAL
   ATHEROSCLEROSIS; METABOLIC SYNDROME; PATHOGENESIS; OBESITY; WATER;
   FERMENTATION; ANTIOXIDANT; HEALTH
AB BackgroundHypercholesterolemia is an independent modifiable risk factor that accelerates the development of both non-alcoholic fatty liver and atherosclerosis. Coconut water contains a variety of phytochemicals that make it appealing for producing vinegar. Coconut vinegar is rapidly gaining popularity for health benefits in Southeast Asia. The purpose of this study is to evaluate the effect of daily supplementation of coconut vinegar on hepatic and vascular oxidative stress in rats fed a high-cholesterol diet (HCD). MethodsMature coconut water was fermented with coconut sap sugar using Saccharomyces cerevisiae and Acetobacter aceti vat Europeans, respectively. Bioactive compounds and antioxidant capacity of coconut vinegar were examined in vitro. Adult male Sprague-Dawley rats were randomly divided into four groups; the control group fed a standard diet (S), a group that received HCD (SC), a group that received HCD supplemented with coconut vinegar at a dose of 1 mL/kg/day (SCV), and a group that received HCD with atorvastatin at a dose of 30 mg/kg/day (SCA). After 8 weeks, serum metabolic profiles, fatty liver, hepatic, and vascular oxidative stress were determined. ResultsIn in vitro studies, coconut vinegar was rich in phenolic compounds and organic acids. The antioxidant capacity of 30 mu L of coconut vinegar was 181.55 +/- 8.15 mu M Trolox equivalent antioxidant capacity (TEAC). In the HCD fed rats, daily supplementation of coconut vinegar reduced weight gain, serum triglycerides, and fasting blood sugar levels without renal or liver toxicity. In the liver, coconut vinegar reduced the accumulation of both hepatic cholesterol and hepatic triglyceride, and it also reduced hepatic 4-hydroxynonenal (4-HNE) lipid peroxidation. In the aortic tissues, coconut vinegar increased nitric oxide bioavailability and reduced aortic 4-HNE lipid peroxidation. ConclusionNovel coconut vinegar is the source of antioxidants, and daily supplementation of coconut vinegar was found to attenuate dyslipidemia-induced hepatic and vascular oxidative stress by protective against cellular lipid peroxidation.
C1 [Malakul, Wachirawadee] Naresuan Univ, Dept Physiol, Fac Med Sci, Phitsanulok, Thailand.
   [Seenak, Porrnthanate; Jumroon, Noppadon; Kumphune, Sarawut; Nernpermpisooth, Nitirut] Naresuan Univ, Fac Allied Hlth Sci, Integrat Biomed Res Unit IBRU, Phitsanulok, Thailand.
   [Seenak, Porrnthanate; Nernpermpisooth, Nitirut] Naresuan Univ, Fac Allied Hlth Sci, Dept Cardiothorac Technol, Phitsanulok, Thailand.
   [Jumroon, Noppadon] Naresuan Univ, Fac Allied Hlth Sci, Dept Med Technol, Phitsanulok, Thailand.
   [Arikit, Siwaret] Kasetsart Univ, Fac Agr Kamphaeng Saen, Dept Agron, Kamphaeng Saen Campus, Kamphaeng Saen, Nakhon Pathom, Thailand.
   [Kumphune, Sarawut] Chiang Mai Univ, Biomed Engn Inst BMEI, Chiang Mai, Thailand.
C3 Naresuan University; Naresuan University; Naresuan University; Naresuan
   University; Kasetsart University; Chiang Mai University
RP Nernpermpisooth, N (corresponding author), Naresuan Univ, Fac Allied Hlth Sci, Integrat Biomed Res Unit IBRU, Phitsanulok, Thailand.; Nernpermpisooth, N (corresponding author), Naresuan Univ, Fac Allied Hlth Sci, Dept Cardiothorac Technol, Phitsanulok, Thailand.
EM nitirutn@nu.ac.th
RI Malakul, Wachirawadee/GQQ-6452-2022; KUMPHUNE, SARAWUT/AAA-9278-2021
OI Malakul, Wachirawadee/0000-0002-1677-2086; Seenak,
   Porrnthanate/0000-0001-8662-8779
FU Biodiversity-Based Economy Development Office (Public Organization);
   National Research Council of Thailand [BEDO-NRCT 48/2562]
FX This work was supported by Biodiversity-Based Economy Development Office
   (Public Organization) and National Research Council of Thailand, grant
   number BEDO-NRCT 48/2562.
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NR 52
TC 6
Z9 7
U1 2
U2 15
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD MAR 9
PY 2022
VL 9
AR 835278
DI 10.3389/fnut.2022.835278
PG 13
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 0G2KF
UT WOS:000777878600001
PM 35356733
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Abbasihormozi, S
   Babapour, V
   Kouhkan, A
   Naslji, AN
   Afraz, K
   Zolfaghary, Z
   Shahverdi, A
AF Abbasihormozi, Shima
   Babapour, Vahab
   Kouhkan, Azam
   Naslji, Amir Niasari
   Afraz, Kaveh
   Zolfaghary, Zahra
   Shahverdi, Abdolhossein
TI Stress Hormone and Oxidative Stress Biomarkers Link Obesity and Diabetes
   with Reduced Fertility Potential
SO CELL JOURNAL
LA English
DT Article
DE Antioxidants; Diabetes; Male Infertility; Obesity; Reactive Oxygen
   Species
ID MALE-INFERTILITY; SEMEN QUALITY; DNA-DAMAGE; REPRODUCTIVE HORMONES;
   METABOLIC SYNDROME; ASSOCIATION; ROS; PARAMETERS; OXIDANTS; MEN
AB Objective: Tilting the balance in favor of antioxidant agents could increase infertility problems in obese and diabetic individuals. The aim of this study was to evaluate oxidative stress status in semen of men with type 2 diabetes and obesity to investigate whether excessive amounts of oxidative stress, as a result of diabetes and obesity, influence infertility potential.
   Materials and Methods: A case-control study was conducted in men (n=150) attending the Infertility Center of Royan Institute between December 2016 and February 2017. Participants were categorized into four groups; normal weight (BMI <25 kg/m(2)) and non-type-2 diabetic (control=40), obese and non-type-2 diabetic (obese=40), non-obese and type-2 diabetic (Nob-DM=35), and obese and type-2 diabetic (Ob-DM=35). The semen analysis was performed according to the World Health Organization criteria. Oxidative stress, DNA fragmentation, sperm apoptosis, and total antioxidant capacity (TAC) were evaluated in semen samples of men. Serum glucose, HbA1c, cortisol, and testosterone levels were determined using the enzyme-linked immunosorbent assay (ELISA) method.
   Results: Compared with the control group, sperm motility, progressive motility, and normal morphology were significantly decreased in the obese, Nob-DM, and Ob-DM groups (P<0.01). The obese, Nob-DM, and Ob-DM groups showed significantly lower levels of TAC and higher amounts of oxidative stress, early apoptotic sperm, and the percentage of DNA fragmentation as compared with the control group (P<0.05). Testosterone concentration was decreased in the obese, Nob-DM, and Ob-DM groups when compared with healthy individuals (P<0.05), whereas the cortisol level was significantly increased in the Nob-DM and Ob-DM groups in comparison to the obese and control group (P<0.01).
   Conclusion: Increased amount of reactive oxygen species (ROS) levels and DNA fragmentation in men affected by either diabetes or obesity could be considered prognostic factors in sub-fertile patients, alerting physicians to an early screen of male patients to avoid the development of infertility in prone patients.
C1 [Abbasihormozi, Shima; Babapour, Vahab] Univ Tehran, Fac Vet Med, Dept Basic Sci, Tehran, Iran.
   [Abbasihormozi, Shima; Shahverdi, Abdolhossein] ACECR, Royan Inst Reprod Biomed, Reprod Biomed Res Ctr, Dept Embryol, Tehran, Iran.
   [Kouhkan, Azam; Zolfaghary, Zahra; Shahverdi, Abdolhossein] ACECR, Royan Inst Reprod Biomed, Reprod Epidemiol Res Ctr, POB 16635-148, Tehran, Iran.
   [Kouhkan, Azam] ACECR, Royan Inst Reprod Biomed, Cell Sci Res Ctr, Dept Regenerat Biomed, Tehran, Iran.
   [Naslji, Amir Niasari] Univ Tehran, Fac Vet Med, Dept Midwifery & Reprod Dis, Tehran, Iran.
   [Afraz, Kaveh] ACECR, Royan Inst Reprod Biomed, Reprod Biomed Res Ctr, Dept Androl, Tehran, Iran.
C3 University of Tehran; Academic Center for Education, Culture & Research
   (ACECR); Academic Center for Education, Culture & Research (ACECR);
   Academic Center for Education, Culture & Research (ACECR); University of
   Tehran; Academic Center for Education, Culture & Research (ACECR)
RP Shahverdi, A (corresponding author), ACECR, Royan Inst Reprod Biomed, Reprod Epidemiol Res Ctr, POB 16635-148, Tehran, Iran.
EM shahverdi@royaninstitute.org
FU Royan Institute
FX We thank Dr. Zahednasab for the proof-reading and edition of the
   manuscript. This study was financially supported by Royan Institute. The
   authors declare no conflict of interests.
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NR 40
TC 42
Z9 44
U1 0
U2 7
PU ROYAN INST
PI TEHRAN
PA PO BOX 19395-4644, TEHRAN, 00000, IRAN
SN 2228-5806
EI 2228-5814
J9 CELL J
JI Cell J.
PD FAL
PY 2019
VL 21
IS 3
BP 307
EP 313
DI 10.22074/cellj.2019.6339
PG 7
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA IE0OW
UT WOS:000472087700011
PM 31210437
DA 2025-06-11
ER

PT J
AU Lee, SJ
   Han, JM
   Lee, JS
   Son, CG
   Im, HJ
   Jo, HK
   Yoo, HR
   Kim, YS
   Seol, IC
AF Lee, Seong-Jong
   Han, Jong-Min
   Lee, Jin-Seok
   Son, Chang-Gue
   Im, Hwi-Jin
   Jo, Hyun-Kyung
   Yoo, Ho-Ryong
   Kim, Yoon-Sik
   Seol, In-Chan
TI ACE Reduces Metabolic Abnormalities in a High-Fat Diet Mouse Model
SO EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Article
ID TRADITIONAL CHINESE MEDICINE; LIPID-METABOLISM; OBESITY; LIVER;
   CHOLESTEROL; CURCUMIN; RECEPTOR; EXTRACT; ASSAYS
AB The medicinal plants Artemisia iwayomogi (A. iwayomogi) and Curcuma longa (C. longa) radix have been used to treat metabolic abnormalities in traditional Korean medicine and traditional Chinese medicine (TKM and TCM). In this study we evaluated the effect of the water extract of a mixture of A. iwayomogi and C. longa (ACE) on high-fat diet-induced metabolic syndrome in a mouse model. Four groups of C57BL/6N male mice (except for the naive group) were fed a high-fat diet freely for 10 weeks. Among these, three groups (except the control group) were administered a high-fat diet supplemented with ACE (100 or 200 mg/kg) or curcumin (50 mg/kg). Body weight, accumulation of adipose tissues in abdomen and size of adipocytes, serum lipid profiles, hepatic steatosis, and oxidative stress markers were analyzed. ACE significantly reduced the body and peritoneal adipose tissue weights, serum lipid profiles (total cholesterol and triglycerides), glucose levels, hepatic lipid accumulation, and oxidative stress markers. ACE normalized lipid synthesis-associated gene expressions (peroxisome proliferator-activated receptor gamma, PPAR gamma; fatty acid synthase, FAS; sterol regulatory element-binding transcription factor-1c, SREBP-1c; and peroxisome proliferator-activated receptor alpha, PPAR alpha). The results from this study suggest that ACE has the pharmaceutical potential reducing the metabolic abnormalities in an animal model.
C1 [Lee, Seong-Jong; Jo, Hyun-Kyung; Yoo, Ho-Ryong; Kim, Yoon-Sik; Seol, In-Chan] Daejeon Univ, Daejeon Oriental Hosp, Internal Med Cardiac Vasc Syst, Daejeon 302869, South Korea.
   [Han, Jong-Min; Lee, Jin-Seok; Son, Chang-Gue; Im, Hwi-Jin] Daejeon Univ, Daejeon Oriental Hosp, Liver & Immunol Res Ctr, Daejeon 301724, South Korea.
C3 Daejeon University; Daejeon University
RP Kim, YS (corresponding author), Daejeon Univ, Daejeon Oriental Hosp, Internal Med Cardiac Vasc Syst, 176-75 Daedeok Daero, Daejeon 302869, South Korea.
EM yoonsik@dju.kr; seolinch@dju.kr
RI Kim, Donghee/C-4288-2013; son, chang gue/ABC-2215-2021
OI Son, Chang-Gue/0000-0003-4876-0167
FU Traditional Korean Medicine R&D Project, Ministry of Health & Welfare,
   Republic of Korea [HI12C-1920-010014]
FX This study was supported by a grant from the Traditional Korean Medicine
   R&D Project, Ministry of Health & Welfare, Republic of Korea
   (HI12C-1920-010014).
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NR 29
TC 6
Z9 6
U1 0
U2 8
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1741-427X
EI 1741-4288
J9 EVID-BASED COMPL ALT
JI Evid.-based Complement Altern. Med.
PY 2015
VL 2015
AR 352647
DI 10.1155/2015/352647
PG 8
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA CT9HV
UT WOS:000363128700001
PM 26508977
OA Green Published, hybrid, Green Submitted
DA 2025-06-11
ER

PT J
AU Tenekecioglu, E
   Yilmaz, M
   Demir, S
   Bekler, A
   Ozluk, OA
   Aydin, U
   Goncu, T
   Yontar, OC
AF Tenekecioglu, E.
   Yilmaz, M.
   Demir, S.
   Bekler, A.
   Ozluk, O. A.
   Aydin, U.
   Goncu, T.
   Yontar, O. C.
TI HDL-cholesterol is associated with systemic inflammation in cardiac
   syndrome X
SO MINERVA MEDICA
LA English
DT Article
DE Microvascular angina; Inflammation; Dyslipidemias
ID HIGH-DENSITY-LIPOPROTEIN; NORMAL CORONARY ARTERIOGRAMS; LONG-TERM
   MORTALITY; APOLIPOPROTEIN-A-I; C-REACTIVE PROTEIN; LYMPHOCYTE RATIO;
   CHEST-PAIN; CARDIOVASCULAR-DISEASE; ARTERY-DISEASE; HEART-DISEASE
AB Aim. Microvascular inflammation is associated with cardiac syndrome X (CSX). High-density lipoprotein cholesterol (HDL-C) reveals antiatherogenic features with stimulating endothelial NO production, inhibiting oxidative stress and vascular inflammation. We investigated relationship between HDL-C and inflammatory markers in CSX.
   Methods. Hundred patients with CSX and control group of 80 subjects were evaluated. Hematologic indices, lipid levels and C-reactive protein (CRP) levels were studied in patients underwent coronary angiography.
   Results. CRP levels were higher in CSX group than control group (4.59 +/- 3.82 mg/dL vs. 2.48 +/- 1.32 mg/dL, P<0.001). HDL-C was significantly lower in CSX group compared to control group (36.5 +/- 4.0 mg/dL vs. 47.5 +/- 12.7 mg/dL, P=0.008). White blood cell (WBC) count was higher in CSX group than in control group. Neutrophil-lymphocyte ratio (NLR) was found significantly increased in CSX group as compared to control group. On multivariate linear regression, lower HDL-C was found to be a significant predictor of higher NLR in patients with CSX independent from other clinical and biochemical variables.
   Conclusion. Lower HDL-C is associated with systemic inflammation in CSX. In patients with typical angina and normal epicardial coronaries,HDL-C and inflammatory markers should be investigated; one of the goals of treatment should be raising HDL-C.
C1 [Tenekecioglu, E.; Yilmaz, M.; Yontar, O. C.] Bursa Yuksek Ihtisas Educ & Res Hosp, Dept Cardiol, TR-16100 Yildirim Bursa, Bursa, Turkey.
   [Demir, S.] Adana Publ Hosp, Dept Cardiol, Adana, Turkey.
   [Bekler, A.] Canakkale Onsekiz Mart Univ, Sch Med, Canakkale, Turkey.
   [Ozluk, O. A.; Aydin, U.; Goncu, T.] Bursa Yuksek Ihtisas Educ & Res Hosp, Bursa, Turkey.
C3 Yuksek Ihtisas Training & Research Hospital; Adana State Hospital;
   Canakkale Onsekiz Mart University; Yuksek Ihtisas Training & Research
   Hospital
RP Tenekecioglu, E (corresponding author), Bursa Yuksek Ihtisas Educ & Res Hosp, Dept Cardiol, Ankara Yolu, TR-16100 Yildirim Bursa, Bursa, Turkey.
EM erhantenekecioglu@yahoo.com
RI TENEKECIOGLU, ERHAN/M-2810-2019; Goncu, Tugrul/AAI-1612-2019; Aydin,
   Ufuk/GRK-0110-2022; Yontar, Osman Can/Z-1452-2018
OI TENEKECIOGLU, ERHAN/0000-0003-4376-2833; Aydin,
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NR 52
TC 9
Z9 10
U1 0
U2 4
PU EDIZIONI MINERVA MEDICA
PI TURIN
PA CORSO BRAMANTE 83-85 INT JOURNALS DEPT., 10126 TURIN, ITALY
SN 0026-4806
EI 1827-1669
J9 MINERVA MED
JI Minerva Med.
PD JUN
PY 2015
VL 106
IS 3
BP 133
EP 141
PG 9
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA CP9AT
UT WOS:000360186800002
PM 25028863
DA 2025-06-11
ER

PT J
AU Androutsakos, T
   Nasiri-Ansari, N
   Bakasis, AD
   Kyrou, I
   Efstathopoulos, E
   Randeva, HS
   Kassi, E
AF Androutsakos, Theodoros
   Nasiri-Ansari, Narjes
   Bakasis, Athanasios-Dimitrios
   Kyrou, Ioannis
   Efstathopoulos, Efstathios
   Randeva, Harpal S.
   Kassi, Eva
TI SGLT-2 Inhibitors in NAFLD: Expanding Their Role beyond Diabetes and
   Cardioprotection
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE non-alcoholic fatty liver disease; NAFLD; MAFLD; SGLT-2; sodium-glucose
   co-transporter type-2 inhibitors; metabolic syndrome
ID FATTY LIVER-DISEASE; COTRANSPORTER 2 INHIBITOR; ENDOPLASMIC-RETICULUM
   STRESS; HEPATIC STEATOSIS; NONALCOHOLIC STEATOHEPATITIS; SELECTIVE
   INHIBITOR; INSULIN-RESISTANCE; ADIPOSE-TISSUE; DIACYLGLYCEROL
   ACYLTRANSFERASE; EMPAGLIFLOZIN IMPROVES
AB Non-alcoholic fatty liver disease (NAFLD) is an 'umbrella' term, comprising a spectrum ranging from benign, liver steatosis to non-alcoholic steatohepatitis, liver fibrosis and eventually cirrhosis and hepatocellular carcinoma. NAFLD has evolved as a major health problem in recent years. Discovering ways to prevent or delay the progression of NAFLD has become a global focus. Lifestyle modifications remain the cornerstone of NAFLD treatment, even though various pharmaceutical interventions are currently under clinical trial. Among them, sodium-glucose co-transporter type-2 inhibitors (SGLT-2i) are emerging as promising agents. Processes regulated by SGLT-2i, such as endoplasmic reticulum (ER) and oxidative stress, low-grade inflammation, autophagy and apoptosis are all implicated in NAFLD pathogenesis. In this review, we summarize the current understanding of the NAFLD pathophysiology, and specifically focus on the potential impact of SGLT-2i in NAFLD development and progression, providing current evidence from in vitro, animal and human studies. Given this evidence, further mechanistic studies would advance our understanding of the exact mechanisms underlying the pathogenesis of NAFLD and the potential beneficial actions of SGLT-2i in the context of NAFLD treatment.
C1 [Androutsakos, Theodoros; Bakasis, Athanasios-Dimitrios] Natl & Kapodistrian Univ Athens, Med Sch, Dept Pathophysiol, Athens 11527, Greece.
   [Nasiri-Ansari, Narjes; Kassi, Eva] Natl & Kapodistrian Univ Athens, Med Sch, Dept Biol Chem, Unit Mol Endocrinol, Athens 11527, Greece.
   [Kyrou, Ioannis; Randeva, Harpal S.] Univ Hosp Coventry & Warwickshire NHS Trust, Warwickshire Inst Study Diabet Endocrinol & Metab, Coventry CV2 2DX, W Midlands, England.
   [Kyrou, Ioannis; Randeva, Harpal S.] Univ Warwick, Warwick Med Sch, Coventry CV4 7AL, W Midlands, England.
   [Kyrou, Ioannis] Agr Univ Athens, Sch Food & Nutr Sci, Dept Food Sci & Human Nutr, Lab Dietet & Qual Life, Athens 11855, Greece.
   [Kyrou, Ioannis] Coventry Univ, Ctr Sport Exercise & Life Sci, Res Inst Hlth & Wellbeing, Coventry CV1 5FB, W Midlands, England.
   [Kyrou, Ioannis] Aston Univ, Coll Hlth & Life Sci, Aston Med Sch, Birmingham B4 7ET, W Midlands, England.
   [Efstathopoulos, Efstathios] Natl & Kapodistrian Univ Athens, Med Sch, Dept Radiol 2, Athens 11527, Greece.
   [Kassi, Eva] Natl & Kapodistrian Univ Athens, Laiko Hosp, Dept Propaedeut Internal Med 1, Endocrine Oncol Unit, Athens 11527, Greece.
C3 National & Kapodistrian University of Athens; National & Kapodistrian
   University of Athens; University of Warwick; University of Warwick;
   Agricultural University of Athens; Coventry University; Aston
   University; National & Kapodistrian University of Athens; Laiko General
   Hospital; National & Kapodistrian University of Athens
RP Kassi, E (corresponding author), Natl & Kapodistrian Univ Athens, Med Sch, Dept Biol Chem, Unit Mol Endocrinol, Athens 11527, Greece.; Randeva, HS (corresponding author), Univ Hosp Coventry & Warwickshire NHS Trust, Warwickshire Inst Study Diabet Endocrinol & Metab, Coventry CV2 2DX, W Midlands, England.; Randeva, HS (corresponding author), Univ Warwick, Warwick Med Sch, Coventry CV4 7AL, W Midlands, England.; Kassi, E (corresponding author), Natl & Kapodistrian Univ Athens, Laiko Hosp, Dept Propaedeut Internal Med 1, Endocrine Oncol Unit, Athens 11527, Greece.
EM t_androutsakos@yahoo.gr; nnasiri@med.uoa.gr; th.bacasis@gmail.com;
   kyrouj@gmail.com; stathise@med.uoa.gr; harpal.randeva@uhcw.nhs.uk;
   ekassi@med.uoa.gr
RI Bakasis, Athanasios Dimitrios/AAA-6487-2022; Androutsakos,
   Theodoros/AAF-5209-2020
OI Androutsakos, Theodoros/0000-0003-2556-6230; Efstathopoulos,
   Efstathios/0000-0003-2747-3353; Bakasis,
   Athanasios-Dimitrios/0000-0001-9465-2162
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NR 184
TC 88
Z9 92
U1 1
U2 19
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD MAR
PY 2022
VL 23
IS 6
AR 3107
DI 10.3390/ijms23063107
PG 32
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 0C5RQ
UT WOS:000775370600001
PM 35328527
OA Green Published, gold, Green Accepted
DA 2025-06-11
ER

PT J
AU Mohammad, K
   Dakik, P
   Medkour, Y
   McAuley, M
   Mitrofanova, D
   Titorenko, VI
AF Mohammad, Karamat
   Dakik, Pamela
   Medkour, Younes
   McAuley, Melissa
   Mitrofanova, Darya
   Titorenko, Vladimir I.
TI Yeast Cells Exposed to Exogenous Palmitoleic Acid Either Adapt to Stress
   and Survive or Commit to Regulated Liponecrosis and Die
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Review
ID CHRONOLOGICAL LIFE-SPAN; SYSTEMS LEVEL STRATEGY;
   SACCHAROMYCES-CEREVISIAE; PLASMA-MEMBRANE; LITHOCHOLIC ACID;
   LIPID-METABOLISM; SPHINGOLIPID METABOLISM; NEUTRAL LIPIDS; RIM101
   PATHWAY; CONTACT SITES
AB A disturbed homeostasis of cellular lipids and the resulting lipotoxicity are considered to be key contributors to many human pathologies, including obesity, metabolic syndrome, type 2 diabetes, cardiovascular diseases, and cancer. The yeast Saccharomyces cerevisiae has been successfully used for uncovering molecular mechanisms through which impaired lipid metabolism causes lipotoxicity and elicits different forms of regulated cell death. Here, we discuss mechanisms of the "liponecrotic" mode of regulated cell death in S. cerevisiae. This mode of regulated cell death can be initiated in response to a brief treatment of yeast with exogenous palmitoleic acid. Such treatment prompts the incorporation of exogenously added palmitoleic acid into phospholipids and neutral lipids. This orchestrates a global remodeling of lipid metabolism and transfer in the endoplasmic reticulum, mitochondria, lipid droplets, and the plasma membrane. Certain features of such remodeling play essential roles either in committing yeast to liponecrosis or in executing this mode of regulated cell death. We also outline four processes through which yeast cells actively resist liponecrosis by adapting to the cellular stress imposed by palmitoleic acid and maintaining viability. These prosurvival cellular processes are confined in the endoplasmic reticulum, lipid droplets, peroxisomes, autophagosomes, vacuoles, and the cytosol.
C1 [Mohammad, Karamat; Dakik, Pamela; Medkour, Younes; McAuley, Melissa; Mitrofanova, Darya; Titorenko, Vladimir I.] Concordia Univ, Dept Biol, Montreal, PQ H4B 1R6, Canada.
C3 Concordia University - Canada
RP Titorenko, VI (corresponding author), Concordia Univ, Dept Biol, Montreal, PQ H4B 1R6, Canada.
EM vladimir.titorenko@concordia.ca
RI Medkour, Younes/AAO-5428-2020
OI Dakik, Pamela/0000-0003-0789-6324
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NR 127
TC 7
Z9 7
U1 5
U2 15
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PY 2018
VL 2018
AR 3074769
DI 10.1155/2018/3074769
PG 11
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA FV8BY
UT WOS:000424811100001
PM 29636840
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Han, GM
   Liu, P
AF Han, Guang-Ming
   Liu, Ping
TI Higher serum lycopene is associated with reduced prevalence of
   hypertension in overweight or obese adults
SO EUROPEAN JOURNAL OF INTEGRATIVE MEDICINE
LA English
DT Article
DE Hypertension; Lycopene; Uric acid; Overweight; Obesity
ID ANGIOTENSIN-ALDOSTERONE SYSTEM; NEW-ONSET HYPERTENSION; OXIDATIVE
   STRESS; BLOOD-PRESSURE; URIC-ACID; CAROTENOID CONCENTRATIONS; METABOLIC
   SYNDROME; NATIONAL-HEALTH; UNITED-STATES; DNA-DAMAGE
AB Introduction: Epidemiologic studies suggest an association between overweight/obesity and hypertension. As a middle mediator between overweight/obesity and hypertension, serum uric acid plays an important role in the renin-angiotensin-aldosterone system. As a natural antioxidant, lycopene can effectively inhibit the angiotensinconverting enzyme activity and attenuate oxidative stress induced by angiotensin-II. Therefore, the objective of this study was to determine whether lycopene could have an association with lower levels of hypertension in individuals who are overweight and obese.
   Methods: A total of 8556 adult participants with BMI >= 25 from the National Health and Nutrition Examination Survey 2001-2006 were used to examine the associations among serum uric acid, serum lycopene and hypertension in this study.
   Results: It was found that there was a significant positive association between serum uric acid and hypertension while there was a significant inverse association between serum lycopene and hypertension. Furthermore, there was a significant association between the ratio of serum lycopene to serum uric acid and hypertension in adults who are overweight/obese.
   Conclusions: Therefore, lycopene has a significant association with lower levels of hypertension in individuals who are overweight and obese.
C1 [Han, Guang-Ming; Liu, Ping] Third Peoples Hosp Bengbu, Dept Rheumatol, Bengbu, Anhui, Peoples R China.
   [Han, Guang-Ming] Univ Nebraska Med Ctr, Dept Epidemiol, Omaha, NE 68198 USA.
   [Liu, Ping] Univ Nebraska, Dept Sociol, Lincoln, NE 68509 USA.
C3 University of Nebraska System; University of Nebraska Medical Center;
   University of Nebraska System; University of Nebraska Lincoln
RP Han, GM (corresponding author), Third Peoples Hosp Bengbu, Dept Rheumatol, Bengbu, Anhui, Peoples R China.; Liu, P (corresponding author), Univ Nebraska, Dept Sociol, Lincoln, NE 68509 USA.
EM ghan54321@gmail.com; pl999999999@gmail.com
RI Han, Guangming/C-6500-2017
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NR 54
TC 19
Z9 20
U1 2
U2 11
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1876-3820
EI 1876-3839
J9 EUR J INTEGR MED
JI Eur. J. Integr. Med.
PD AUG
PY 2017
VL 13
BP 34
EP 40
DI 10.1016/j.eujim.2017.07.002
PG 7
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA FL4VS
UT WOS:000414230200004
DA 2025-06-11
ER

PT J
AU Kola, B
   Wittman, G
   Bodnár, I
   Amin, F
   Lim, CT
   Oláh, M
   Christ-Crain, M
   Lolli, F
   van Thuijl, H
   Leontiou, CA
   Füzesi, T
   Dalino, P
   Isidori, AM
   Harvey-White, J
   Kunos, G
   Nagy, GM
   Grossman, AB
   Fekete, C
   Korbonits, M
AF Kola, Blerina
   Wittman, Gabor
   Bodnar, Ibolya
   Amin, Faisal
   Lim, Chung Thong
   Olah, Mark
   Christ-Crain, Mirjam
   Lolli, Francesca
   van Thuijl, Hinke
   Leontiou, Chrysanthia A.
   Fuezesi, Tamas
   Dalino, Paolo
   Isidori, Andrea M.
   Harvey-White, Judith
   Kunos, George
   Nagy, Gyoergy M.
   Grossman, Ashley B.
   Fekete, Csaba
   Korbonits, Marta
TI The CB1 receptor mediates the peripheral effects of ghrelin on AMPK
   activity but not on growth hormone release
SO FASEB JOURNAL
LA English
DT Article
DE cannabinoids; rimonabant; CB1 knockout
ID ACTIVATED PROTEIN-KINASE; MESSENGER-RNA EXPRESSION; FOOD-INTAKE;
   ENDOCANNABINOID SYSTEM; CARDIOMETABOLIC RISK; CARDIAC DYSFUNCTION;
   OXIDATIVE STRESS; ADIPOSE-TISSUE; RIMONABANT; OBESITY
AB This study aimed to investigate whether the growth hormone release and metabolic effects of ghrelin on AMPK activity of peripheral tissues are mediated by cannabinoid receptor type 1 (CB1) and the central nervous system. CB1-knockout (KO) and/or wild-type mice were injected peripherally or intracerebroventricularly with ghrelin and CB1 antagonist rimonabant to study tissue AMPK activity and gene expression (transcription factors SREBP1c, transmembrane protein FAS, enzyme PEPCK, and protein HSL). Growth hormone levels were studied both in vivo and in vitro. Peripherally administered ghrelin in liver, heart, and adipose tissue AMPK activity cannot be observed in CB1-KO or CB1 antagonist-treated mice. Intracerebroventricular ghrelin treatment can influence peripheral AMPK activity. This effect is abolished in CB1-KO mice and by intracerebroventricular rimonabant treatment, suggesting that central CB1 receptors also participate in the signaling pathway that mediates the effects of ghrelin on peripheral tissues. Interestingly, in vivo or in vitro growth hormone release is intact in response to ghrelin in CB1-KO animals. Our data suggest that the metabolic effects of ghrelin on AMPK in peripheral tissues are abolished by the lack of functional CB1 receptor via direct peripheral effect and partially through the central nervous system, thus supporting the existence of a possible ghrelin-cannabinoid-CB1-AMPK pathway.
C1 [Kola, Blerina; Amin, Faisal; Lim, Chung Thong; Christ-Crain, Mirjam; Lolli, Francesca; van Thuijl, Hinke; Leontiou, Chrysanthia A.; Dalino, Paolo; Grossman, Ashley B.; Korbonits, Marta] Queen Mary Univ London, Barts & London Med Sch, Ctr Endocrinol, London, England.
   [Wittman, Gabor; Fuezesi, Tamas; Fekete, Csaba] Hungarian Acad Sci, Inst Expt Med, Dept Endocrine Neurobiol, Budapest, Hungary.
   [Wittman, Gabor; Fekete, Csaba] Tufts Med Ctr, Div Endocrinol Diabet Metab & Mol Med, Dept Med, Boston, MA USA.
   [Bodnar, Ibolya; Olah, Mark; Nagy, Gyoergy M.] Semmelweis Univ, Fac Med, Dept Human Morphol & Dev Biol, H-1085 Budapest, Hungary.
   [Dalino, Paolo] Osped Niguarda Ca Granda, Endocrinol Unit, Milan, Italy.
   [Isidori, Andrea M.] Univ Roma La Sapienza, Dept Med Pathophysiol, I-00185 Rome, Italy.
   [Harvey-White, Judith; Kunos, George] NIAAA, Lab Physiol Studies, NIH, Bethesda, MD USA.
   [Grossman, Ashley B.] Univ Oxford, Oxford Ctr Diabet Endocrinol & Metab, Oxford, England.
C3 University of London; Queen Mary University London; Hungarian Academy of
   Sciences; HUN-REN; HUN-REN Institute of Experimental Medicine; Tufts
   Medical Center; Semmelweis University; IRCCS Ca Granda Ospedale Maggiore
   Policlinico; Ospedale Niguarda Ca' Granda; Sapienza University Rome;
   National Institutes of Health (NIH) - USA; NIH National Institute on
   Alcohol Abuse & Alcoholism (NIAAA); University of Oxford
RP Korbonits, M (corresponding author), Barts & London Queen Marys Sch Med & Dent, Dept Endocrinol, Charterhouse Sq, London EC1M 6BQ, England.
EM m.korbonits@qmul.ac.uk
RI Isidori, Andrea/F-3062-2010; MÃ¼ller, Christoph/JAN-8694-2023;
   Korbonits, Marta/AFV-9501-2022
OI Korbonits, Marta/0000-0002-4101-9432; Isidori,
   Andrea/0000-0002-9037-5417; Fekete, Csaba/0000-0002-8206-562X;
   Christ-Crain, Mirjam/0000-0002-6336-0965
FU Wellcome Trust Project Grant; Seventh EU Research Framework Program
   [Health-F2-2010-259772]; Lendulet Award of the Hungarian Academy of
   Sciences
FX The study was supported by a Wellcome Trust Project Grant, the Seventh
   EU Research Framework Program (Health-F2-2010-259772), and a Lendulet
   Award of the Hungarian Academy of Sciences.
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NR 56
TC 23
Z9 26
U1 0
U2 10
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
EI 1530-6860
J9 FASEB J
JI Faseb J.
PD DEC
PY 2013
VL 27
IS 12
BP 5112
EP 5121
DI 10.1096/fj.13-232918
PG 10
WC Biochemistry & Molecular Biology; Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 293UK
UT WOS:000329999000043
PM 23982145
OA Green Published
DA 2025-06-11
ER

PT J
AU Yokota, T
   Kinugawa, S
   Hirabayashi, K
   Matsushima, S
   Inoue, N
   Ohta, Y
   Hamaguchi, S
   Sobirin, MA
   Ono, T
   Suga, T
   Kuroda, S
   Tanaka, S
   Terasaki, F
   Okita, K
   Tsutsui, H
AF Yokota, Takashi
   Kinugawa, Shintaro
   Hirabayashi, Kagami
   Matsushima, Shouji
   Inoue, Naoki
   Ohta, Yukihiro
   Hamaguchi, Sanae
   Sobirin, Mochamad A.
   Ono, Taisuke
   Suga, Tadashi
   Kuroda, Satoshi
   Tanaka, Shinya
   Terasaki, Fumio
   Okita, Koichi
   Tsutsui, Hiroyuki
TI Oxidative stress in skeletal muscle impairs mitochondrial respiration
   and limits exercise capacity in type 2 diabetic mice
SO AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
LA English
DT Article
DE exercise intolerance; insulin resistance; mitochondrial function; oxygen
   uptake; superoxide
ID DIET-INDUCED OBESITY; NAD(P)H OXIDASE; INSULIN-RESISTANCE; METABOLIC
   SYNDROME; HEART-FAILURE; NADPH OXIDASE; KNOCKOUT MICE; NITRIC-OXIDE;
   DYSFUNCTION; RATS
AB Yokota T, Kinugawa S, Hirabayashi K, Matsushima S, Inoue N, Ohta Y, Hamaguchi S, Sobirin MA, Ono T, Suga T, Kuroda S, Tanaka S, Terasaki F, Okita K, Tsutsui H. Oxidative stress in skeletal muscle impairs mitochondrial respiration and limits exercise capacity in type 2 diabetic mice. Am J Physiol Heart Circ Physiol 297: H1069-H1077, 2009. First published July 17, 2009; doi: 10.1152/ajpheart.00267.2009.-Insulin resistance or diabetes is associated with limited exercise capacity, which can be caused by the abnormal energy metabolism in skeletal muscle. Oxidative stress is involved in mitochondrial dysfunction in diabetes. We hypothesized that increased oxidative stress could cause mitochondrial dysfunction in skeletal muscle and make contribution to exercise intolerance in diabetes. C57/BL6J mice were fed on normal diet or high fat diet (HFD) for 8 wk to induce obesity with insulin resistance and diabetes. Treadmill tests with expired gas analysis were performed to determine the exercise capacity and whole body oxygen uptake ((V) over dotO(2))). The work (vertical distance x body weight) to exhaustion was reduced in the HFD mice by 36%, accompanied by a 16% decrease of peak (V) over dotO(2). Mitochondrial ADP-stimulated respiration, electron transport chain complex I and III activities, and mitochondrial content in skeletal muscle were decreased in the HFD mice. Furthermore, superoxide production and NAD(P)H oxidase activity in skeletal muscle were significantly increased in the HFD mice. Intriguingly, the treatment of HFD-fed mice with apocynin [10 mmol/l; an inhibitor of NAD(P)H oxidase activation] improved exercise intolerance and mitochondrial dysfunction in skeletal muscle without affecting glucose metabolism itself. The exercise capacity and mitochondrial function in skeletal muscle were impaired in type 2 diabetes, which might be due to enhanced oxidative stress. Therapies designed to regulate oxidative stress and maintain mitochondrial function could be beneficial to improve the exercise capacity in type 2 diabetes.
C1 [Kinugawa, Shintaro] Hokkaido Univ, Dept Cardiovasc Med, Grad Sch Med, Kita Ku, Sapporo, Hokkaido 0608638, Japan.
   [Kuroda, Satoshi] Hokkaido Univ, Dept Neurosurg, Grad Sch Med, Sapporo, Hokkaido 0608638, Japan.
   [Tanaka, Shinya] Hokkaido Univ, Lab Mol & Cellular Pathol, Grad Sch Med, Sapporo, Hokkaido 0608638, Japan.
   [Terasaki, Fumio] Hokusho Univ, Osaka Med Coll, Dept Internal Med 3, Ebetsu, Hokkaido, Japan.
   [Okita, Koichi] Hokusho Univ, Grad Sch, Program Lifelong Learning Studies, Ebetsu, Hokkaido, Japan.
C3 Hokkaido University; Hokkaido University; Hokkaido University
RP Kinugawa, S (corresponding author), Hokkaido Univ, Dept Cardiovasc Med, Grad Sch Med, Kita Ku, Kita 15,Nishi 7, Sapporo, Hokkaido 0608638, Japan.
EM tuckahoe@med.hokudai.ac.jp
RI matsushima, shouji/IUO-9529-2023; Kinugawa, Shintaro/E-1268-2012;
   Tanaka, Shinya/D-3586-2011; Inoue, Naoki/AAG-5171-2019; Tsutsui,
   Hiroyuki/A-4070-2012
OI sobirin, mochamad ali/0000-0001-9558-4966
FU Ministry of Education, Science, and Culture [18790487, 17390223,
   20590854]; Japan Heart Foundation/Novartis; Grants-in-Aid for Scientific
   Research [20590854, 18790487, 17390223] Funding Source: KAKEN
FX This work was supported in part by grants from the Ministry of
   Education, Science, and Culture (18790487, 17390223, and 20590854) and
   Japan Heart Foundation/Novartis Grant for Research Award on Molecular
   and Cellular Cardiology.
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NR 35
TC 106
Z9 124
U1 0
U2 16
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0363-6135
EI 1522-1539
J9 AM J PHYSIOL-HEART C
JI Am. J. Physiol.-Heart Circul. Physiol.
PD SEP
PY 2009
VL 297
IS 3
BP H1069
EP H1077
DI 10.1152/ajpheart.00267.2009
PG 9
WC Cardiac & Cardiovascular Systems; Physiology; Peripheral Vascular
   Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Physiology
GA 487WP
UT WOS:000269308900020
PM 19617406
DA 2025-06-11
ER

PT J
AU Sharma, A
   Lee, HJ
AF Sharma, Anshul
   Lee, Hae-Jeung
TI A Review on the Protecting Effects and Molecular Mechanisms of Berries
   Against a Silent Public Health Concern: Non-Alcoholic Fatty Liver
   Disease
SO ANTIOXIDANTS
LA English
DT Review
DE berries; oxidative stress; steatosis; gut microbiota; reactive oxygen
   species; inflammation
ID PHYLLANTHUS-EMBLICA L.; AMELANCHIER-ALNIFOLIA NUTT.; GUT MICROBIOTA;
   BIOACTIVE CONSTITUENTS; ARONIA-MELANOCARPA; METABOLIC SYNDROME; HEPATIC
   STEATOSIS; LIPID-METABOLISM; RIBES-NIGRUM; HEPG2 CELLS
AB Non-alcoholic fatty liver disease (NAFLD) poses a silent threat to human health, with prevalence rising at an alarming rate. The treatment and prevention of NAFLD depend on novel approaches as no effective treatment options are currently available. Berries are unique sources of phenolic compounds that have proven roles in disease prevention and health promotion. However, a comprehensive review of the effects of different berries on NAFLD and related pathologies is lacking. Thus, the present review aims to summarize the effects of berry extracts, plant parts, and bioactive compounds from twenty-one different berries on NAFLD. The molecular mechanisms involved include the regulation of lipid homeostasis, modulation of oxidative stress and inflammation markers, and activation of different signaling pathways in different in vitro and in vivo NAFLD models. Furthermore, their modulatory effects on the gut microbiota have also been highlighted. Clinical intervention research on the benefits of berries in NAFLD is limited; nonetheless, this paper discusses clinical studies demonstrating the effects of different berries in people with NAFLD. Future research should focus on long-term clinical studies to compare the therapeutic potentials of different berries against NAFLD.
C1 [Sharma, Anshul; Lee, Hae-Jeung] Gachon Univ, Coll Bio Nano Technol, Dept Food & Nutr, Seongnam Si 13120, Gyeonggi Do, South Korea.
   [Sharma, Anshul; Lee, Hae-Jeung] Gachon Univ, Inst Aging & Clin Nutr Res, Seongnam Si 13120, Gyeonggi Do, South Korea.
   [Lee, Hae-Jeung] Gachon Univ, GAIHST, Dept Hlth Sci & Technol, Incheon 21999, South Korea.
C3 Gachon University; Gachon University; Gachon University
RP Lee, HJ (corresponding author), Gachon Univ, Coll Bio Nano Technol, Dept Food & Nutr, Seongnam Si 13120, Gyeonggi Do, South Korea.; Lee, HJ (corresponding author), Gachon Univ, Inst Aging & Clin Nutr Res, Seongnam Si 13120, Gyeonggi Do, South Korea.; Lee, HJ (corresponding author), Gachon Univ, GAIHST, Dept Hlth Sci & Technol, Incheon 21999, South Korea.
EM anshulsharma@gachon.ac.kr; skysea@gachon.ac.kr
FU Korea Forest Service (Korea Forestry Promotion Institute); R&D Program
   for Forest Science Technology [RS-2024-00404250]
FX This study was supported by the R&D Program for Forest Science
   Technology (Project No. RS-2024-00404250), provided by the Korea Forest
   Service (Korea Forestry Promotion Institute).
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NR 177
TC 0
Z9 0
U1 2
U2 2
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD NOV
PY 2024
VL 13
IS 11
AR 1389
DI 10.3390/antiox13111389
PG 38
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA N3Q1N
UT WOS:001363515500001
PM 39594531
OA gold
DA 2025-06-11
ER

PT J
AU Bagul, PK
   Banerjee, SK
AF Bagul, P. K.
   Banerjee, S. K.
TI Application of Resveratrol in Diabetes: Rationale, Strategies and
   Challenges
SO CURRENT MOLECULAR MEDICINE
LA English
DT Article
DE Clinical studies; insulin resistance; molecular mechanism; resveratrol;
   diabetes; sirtuins
ID ACTIVATED PROTEIN-KINASE; PANCREATIC BETA-CELL; INDUCED
   INSULIN-RESISTANCE; TRANS-RESVERATROL; HIGH-FAT; OXIDATIVE STRESS; RED
   WINE; ADIPOSE-TISSUE; HEALTHY-VOLUNTEERS; METABOLIC SYNDROME
AB The increasing prevalence, involvement of several signaling pathways, variable pathogenesis, progressive natural history and complications of type 2 diabetes emphasize an urgent need for a molecule with multiple actions. Resveratrol (3,5,4'-trihydroxy-trans-stilbene) is a polyphenolic antioxidant present in red wine gaining a worldwide interest because of its multi-target effect against diabetes and other life-threatening diseases. Improving insulin sensitivity, enhancing GLUT4 translocation, reducing oxidative stress, regulating carbohydrate metabolizing enzymes, activating SIRT1 and AMPK, and decreasing adipogenic genes are some promising mechanisms established until now for resveratrol. Apart from these, resveratrol attenuates the end organ damage and reduced diabetic complications. Resveratrol exerts its beneficial antidiabetic action as evidenced from the in vitro, preclinical and clinical studies. Considering all the benefits of resveratrol in diabetes, resveratrol based different nutraceutical products have been developed commercially to use in humans. However, this compound is still under investigation because of some limitations. Resveratrol can be taken in to account in the treatment of diabetes after overcoming all hurdles and difficulties. This article examines the basic scientific evidences, animal experiments, and human/clinical data supporting the antidiabetic action of resveratrol and describes the strategies and challenges to recommend resveratrol from preclinical to clinical use.
C1 [Bagul, P. K.; Banerjee, S. K.] Drug Discovery Res Ctr, Translat Hlth Sci & Technol Inst, Faridabad 120001, India.
C3 Department of Biotechnology (DBT) India; Translational Health Science &
   Technology Institute (THSTI)
RP Banerjee, SK (corresponding author), Drug Discovery Res Ctr, Translat Hlth Sci & Technol Inst, Faridabad 120001, India.
EM skbanerjee@thsti.res.in
RI Dr. Pankaj K. Bagul, M.S/I-3867-2012
OI Banerjee, Sanjay k/0000-0002-0044-0984; Banerjee,
   Sanjay/0000-0002-0008-0480
FU DBT [BT/PR6143/FNS/20/637/2012]; Council of Scientific and Industrial
   Research (CSIR) (EpiHead), Govt. of India; Council of Scientific and
   Industrial Research (CSIR), Govt. of India
FX SKB has grant support from DBT (BT/PR6143/FNS/20/637/2012) and Council
   of Scientific and Industrial Research (CSIR) (EpiHead), Govt. of India;
   and PKB is a Senior Research Fellow from Council of Scientific and
   Industrial Research (CSIR), Govt. of India.
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NR 165
TC 44
Z9 48
U1 0
U2 38
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1566-5240
EI 1875-5666
J9 CURR MOL MED
JI Curr. Mol. Med.
PY 2015
VL 15
IS 4
BP 312
EP 330
DI 10.2174/1566524015666150505155702
PG 19
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA CJ6DX
UT WOS:000355584900003
PM 25941821
DA 2025-06-11
ER

PT J
AU Elzinga, SE
   Guo, K
   Turfah, A
   Henn, RE
   Webber-Davis, IF
   Hayes, JM
   Pacut, CM
   Teener, SJ
   Carter, AD
   Rigan, DM
   Allouch, AM
   Jang, DG
   Parent, R
   Glass, E
   Murphy, GG
   Lentz, SI
   Chen, KS
   Zhao, LL
   Hur, J
   Feldman, EL
AF Elzinga, Sarah E.
   Guo, Kai
   Turfah, Ali
   Henn, Rosemary E.
   Webber-Davis, Ian F.
   Hayes, John M.
   Pacut, Crystal M.
   Teener, Samuel J.
   Carter, Andrew D.
   Rigan, Diana M.
   Allouch, Adam M.
   Jang, Dae-Gyu
   Parent, Rachel
   Glass, Emily
   Murphy, Geoffrey G.
   Lentz, Stephen I.
   Chen, Kevin S.
   Zhao, Lili
   Hur, Junguk
   Feldman, Eva L.
TI Metabolic stress and age drive inflammation and cognitive decline in
   mice and humans
SO ALZHEIMERS & DEMENTIA
LA English
DT Article
DE cognitive impairment; hippocampus; human; inflammation; microglia;
   mouse; obesity; prediabetes; type 2 diabetes
ID UNITED-STATES; KAPPA-B; OBESITY; OSTEOPONTIN; ACTIVATION; EXPRESSION;
   MICROGLIA; NEURODEGENERATION; ALZHEIMERS; MIDLIFE
AB INTRODUCTIONMetabolic stressors (obesity, metabolic syndrome, prediabetes, and type 2 diabetes [T2D]) increase the risk of cognitive impairment (CI), including Alzheimer's disease (AD). Immune system dysregulation and inflammation, particularly microglial mediated, may underlie this risk, but mechanisms remain unclear.METHODSUsing a high-fat diet-fed (HFD) model, we assessed longitudinal metabolism and cognition, and terminal inflammation and brain spatial transcriptomics. Additionally, we performed hippocampal spatial transcriptomics and single-cell RNA sequencing of post mortem tissue from AD and T2D human subjects versus controls.RESULTSHFD induced progressive metabolic and CI with terminal inflammatory changes, and dysmetabolic, neurodegenerative, and inflammatory gene expression profiles, particularly in microglia. AD and T2D human subjects had similar gene expression changes, including in secreted phosphoprotein 1 (SPP1), a pro-inflammatory gene associated with AD.DISCUSSIONThese data show that metabolic stressors cause early and progressive CI, with inflammatory changes that promote disease. They also indicate a role for microglia, particularly microglial SPP1, in CI.Highlights Metabolic stress causes persistent metabolic and cognitive impairments in mice. Murine and human brain spatial transcriptomics align and indicate a pro-inflammatory milieu. Transcriptomic data indicate a role for microglial-mediated inflammatory mechanisms. Secreted phosphoprotein 1 emerged as a potential target of interest in metabolically driven cognitive impairment.
C1 [Elzinga, Sarah E.; Guo, Kai; Henn, Rosemary E.; Webber-Davis, Ian F.; Hayes, John M.; Pacut, Crystal M.; Teener, Samuel J.; Carter, Andrew D.; Rigan, Diana M.; Allouch, Adam M.; Jang, Dae-Gyu; Chen, Kevin S.; Feldman, Eva L.] Univ Michigan, Dept Neurol, Ann Arbor, MI USA.
   [Turfah, Ali; Zhao, Lili] Univ Michigan, Sch Publ Hlth, Dept Biostat, Ann Arbor, MI USA.
   [Parent, Rachel] Univ Michigan, Dept Internal Med, Gen Med, Ann Arbor, MI USA.
   [Glass, Emily; Murphy, Geoffrey G.] Univ Michigan, Dept Mol & Integrat Physiol, Div Cardiovasc Med, Ann Arbor, MI USA.
   [Lentz, Stephen I.] Univ Michigan, Dept Internal Med, Div Metab Endocrinol & Diabet, Ann Arbor, MI USA.
   [Chen, Kevin S.] Univ Michigan, Dept Neurosurg, Ann Arbor, MI USA.
   [Hur, Junguk] Univ North Dakota, Dept Biomed Sci, Grand Forks, ND USA.
   [Elzinga, Sarah E.] Michigan State Univ, Dept Physiol, 2201 Biomed & Phys Sci,567 Wilson Rd, E Lansing, MI 48824 USA.
C3 University of Michigan System; University of Michigan; University of
   Michigan System; University of Michigan; University of Michigan System;
   University of Michigan; University of Michigan System; University of
   Michigan; University of Michigan System; University of Michigan;
   University of Michigan System; University of Michigan; University of
   North Dakota Grand Forks; Michigan State University
RP Elzinga, SE (corresponding author), Michigan State Univ, Dept Physiol, 2201 Biomed & Phys Sci,567 Wilson Rd, E Lansing, MI 48824 USA.
EM seelzing@med.umich.edu
RI Jang, Dae-Gyu/MYQ-8578-2025; Zhao, Lili/KHC-5603-2024
OI Zhao, Lili/0000-0002-6366-8206
FU Cure PSP (AD Knowledge Portal); Advanced Genomics Core at the University
   of Michigan [P30CA046592]; National Cancer Institutes of Health
   [P30AG053760/P30AG072931]; University of Michigan Alzheimer's Disease
   Core Center [P30AG10161, P30AG72975, R01AG15819, R01AG17917,
   R01AG036836, U01AG46152, U01AG61356, U01AG046139, P50 AG016574, R01
   AG032990, R01AG018023, U01AG006576, U01AG006786, R01AG025711,
   R01AG017216, R01AG003949, R01NS080820, U24NS072026, P30AG19610,
   U01AG046170, RF1AG057440, U24AG061340]; NIH; Cure PSP; Arizona
   Department of Health Services; Arizona Biomedical Research Commission;
   Sun Health Research Institute Brain and Body Donation Program; Mayo
   Clinic Brain Bank [P30CA046592, P30AG053760/P30AG072931, K99AG071667,
   R01 DK130913, P30EY007003, P30DK020572]; National Institutes of Health
   [AACSF-22-970586]; Alzheimer's Association; Program for Alzheimer's
   Research; Andrea and Lawrence A. Wolfe Brain Health Initiative; Frank L.
   and Helen Gofrank Foundation Research Program in Alzheimer's Disease and
   Brain Health; Kiriluk Family Fund for Brain Health Research; Robert and
   Katherine Jacobs Environmental Health Initiative; Sinai Medical Staff
   Foundation Research on Studying Diet and Brain Health Fund; Kenneth and
   Frances Eisenberg Emerging Scholar Fund; Edith S. Briskin/SKS Foundation
   NeuroNetwork Emerging Scholar Fund; Handleman Emerging Scholar Fund;
   Tauber Family Student Internship Program; Taubman Foundation;
   NeuroNetwork for Emerging Therapies
FX Library prep and next-generation sequencing was carried out by the
   Advanced Genomics Core at the University of Michigan. Research reported
   in this publication was supported by the National Cancer Institutes of
   Health under Award Number P30CA046592 by the use of the following Cancer
   Center Shared Resource: Single Cell and Spatial Analysis Shared
   Resource. Human samples were obtained from the Michigan Brain Bank, a
   University of Michigan Alzheimer's Disease Core Center
   (P30AG053760/P30AG072931), a University of Michigan Alzheimer's Disease
   Core Center, and in collaboration with the Michigan Alzheimer's Disease
   Research Center. Authors would like to acknowledge Dr. Bhumsoo Kim for
   his technical assistance, Dr. Stacey Sakowski Jacoby for her assistance
   in applying for AD Knowledge Portal data, and Dr. Emily Koubek for her
   assistance in formatting and submitting the manuscript. The results
   published here are in part based on data obtained from the AD Knowledge
   Portal (). Data generation was supported by the following NIH grants:
   P30AG10161, P30AG72975, R01AG15819, R01AG17917, R01AG036836, U01AG46152,
   U01AG61356, U01AG046139, P50 AG016574, R01 AG032990, U01AG046139,
   R01AG018023, U01AG006576, U01AG006786, R01AG025711, R01AG017216,
   R01AG003949, R01NS080820, U24NS072026, P30AG19610, U01AG046170,
   RF1AG057440, and U24AG061340, and the Cure PSP, Mayo and Michael J Fox
   foundations, Arizona Department of Health Services and the Arizona
   Biomedical Research Commission. The authors thank the participants of
   the Religious Order Study and Memory and Aging Project for the generous
   donation, the Sun Health Research Institute Brain and Body Donation
   Program, the Mayo Clinic Brain Bank, and the Mount Sinai/JJ Peters VA
   Medical Center NIH Brain and Tissue Repository. Data and analysis
   contributing investigators include Nilufer Ertekin-Taner, Steven Younkin
   (Mayo Clinic, Jacksonville, FL), Todd Golde (University of Florida),
   Nathan Price (Institute for Systems Biology), David Bennett, Christopher
   Gaiteri (Rush University), Philip De Jager (Columbia University), Bin
   Zhang, Eric Schadt, Michelle Ehrlich, Vahram Haroutunian, Sam Gandy
   (Icahn School of Medicine at Mount Sinai), Koichi Iijima (National
   Center for Geriatrics and Gerontology, Japan), Scott Noggle (New York
   Stem Cell Foundation), Lara Mangravite (Sage Bionetworks). This work was
   supported by the National Institutes of Health (K99AG071667 to Sarah E.
   Elzinga, R01 DK130913 to Eva L. Feldman and Junguk Hur, P30EY007003 to
   Vision Research Center - SIL, P30DK020572 to Michigan Diabetes Research
   Center - SIL, P30AG053760/P30AG072931 to Michigan Brain Bank, University
   of Michigan Alzheimer's Disease Core Center, S10OD28612-01-A1 to SIL,
   P30CA046592 to Advanced Genomics Core); the Alzheimer's Association
   (AACSF-22-970586 to KSC); the Robert E. Nederlander Sr. Program for
   Alzheimer's Research (to Eva L. Feldman); the Andrea and Lawrence A.
   Wolfe Brain Health Initiative (to Eva L. Feldman); the Frank L. and
   Helen Gofrank Foundation Research Program in Alzheimer's Disease and
   Brain Health (to Eva L. Feldman); the Kiriluk Family Fund for Brain
   Health Research (to Eva L. Feldman); the Robert and Katherine Jacobs
   Environmental Health Initiative (to Eva L. Feldman); the Sinai Medical
   Staff Foundation Research on Studying Diet and Brain Health Fund (to Eva
   L. Feldman); the Kenneth and Frances Eisenberg Emerging Scholar Fund (to
   Kevin S. Chen); the Edith S. Briskin/SKS Foundation NeuroNetwork
   Emerging Scholar Fund (to Sarah E. Elzinga); the Handleman Emerging
   Scholar Fund (to Kevin S. Chen); the Tauber Family Student Internship
   Program (to Adam M. Allouch); the Taubman Foundation (to Eva L.
   Feldman); and the NeuroNetwork for Emerging Therapies (to Eva L.
   Feldman). Funding sources were not involved in the study design,
   collection, analysis, and interpretation of data, in the writing of the
   report, or in the decision to submit the article for publication. All
   living participants completed a donation pre-registration consent form.
   A verbal consent for autopsy from the participant's next of kin was
   obtained through our Michigan Medicine autopsy consent line.
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NR 77
TC 0
Z9 0
U1 2
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1552-5260
EI 1552-5279
J9 ALZHEIMERS DEMENT
JI Alzheimers. Dement.
PD MAR
PY 2025
VL 21
IS 3
AR e70060
DI 10.1002/alz.70060
PG 20
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 0JE6J
UT WOS:001448646200001
PM 40110679
OA hybrid
DA 2025-06-11
ER

PT J
AU Lee, JH
   Friso, S
   Choi, SW
AF Lee, Joo Ho
   Friso, Simonetta
   Choi, Sang-Woon
TI Epigenetic Mechanisms Underlying the Link between Non-Alcoholic Fatty
   Liver Diseases and Nutrition
SO NUTRIENTS
LA English
DT Review
DE epigenetics; non-alcoholic fatty liver disease (NAFLD); non-alcoholic
   steatohepatitis (NASH); one-carbon metabolism; nutrition
ID ENDOPLASMIC-RETICULUM STRESS; ACTIVATED RECEPTOR-GAMMA; DNA METHYLATION;
   HEPATOCELLULAR-CARCINOMA; INSULIN-RESISTANCE; HEPATIC STEATOSIS;
   CHOLINE-DEFICIENT; RISK-FACTORS; S-ADENOSYLMETHIONINE;
   HISTONE-MODIFICATION
AB Non-alcoholic fatty liver disease (NAFLD) is defined as a pathologic accumulation of fat in the form of triglycerides (TG) in the liver (steatosis) that is not caused by alcohol. A subgroup of NAFLD patients shows liver cell injury and inflammation coupled with the excessive fat accumulation (steatohepatitis), which is referred to as non-alcoholic steatohepatitis (NASH). Patients with NASH may develop cirrhosis and hepatocellular carcinoma (HCC). NAFLD shares the key features of metabolic syndrome including obesity, hyperlipidemia, hypertension, and insulin resistance. The pathogenesis of NAFLD is multi-factorial, however the oxidative stress seems to plays a major role in the development and progression of the disease. The emerging field of epigenetics provides a new perspective on the pathogenesis of NAFLD. Epigenetics is an inheritable but reversible phenomenon that affects gene expression without altering the DNA sequence and refers to DNA methylation, histone modifications and microRNAs. Epigenetic manipulation through metabolic pathways such as one-carbon metabolism has been proposed as a promising approach to retard the progression of NAFLD. Investigating the epigenetic modifiers in NAFLD may also lead to the development of preventive or therapeutic strategies for NASH-associated complications.
C1 [Friso, Simonetta] CHA Univ Sch Med, Bundang CHA Hosp, Dept Gastroenterol, Seoul 463712, South Korea.
   [Friso, Simonetta] Univ Verona Sch Med, Dept Med, I-37134 Verona, Italy.
   [Choi, Sang-Woon] CHA Univ Sch Med, Chaum Life Ctr, Clin Genom Ctr, Seoul 135948, South Korea.
RP Choi, SW (corresponding author), CHA Univ Sch Med, Chaum Life Ctr, Clin Genom Ctr, Seoul 135948, South Korea.
EM piolee2000@naver.com; simonetta.friso@gmail.com; sang.choi@cha.ac.kr
RI Lee, Joo/AAS-2614-2021; Friso, Simonetta/K-4715-2016
FU Ministry of Science, ICT and Future Planning through the National
   Research Foundation [NRF-2012M3A9C4048735]
FX This work was supported by the Bio-Synergy Research Project
   (NRF-2012M3A9C4048735) of the Ministry of Science, ICT and Future
   Planning through the National Research Foundation (S.W.C.).
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NR 150
TC 97
Z9 102
U1 0
U2 36
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 2072-6643
J9 NUTRIENTS
JI Nutrients
PD AUG
PY 2014
VL 6
IS 8
BP 3303
EP 3325
DI 10.3390/nu6083303
PG 23
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA AO3AB
UT WOS:000341199100021
PM 25195642
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Dasgupta, B
   Ju, JS
   Sasaki, Y
   Liu, XN
   Jung, SR
   Higashida, K
   Lindquist, D
   Milbrandt, J
AF Dasgupta, Biplab
   Ju, Jeong Sun
   Sasaki, Yo
   Liu, Xiaona
   Jung, Su-Ryun
   Higashida, Kazuhiko
   Lindquist, Diana
   Milbrandt, Jeffrey
TI The AMPK β2 Subunit Is Required for Energy Homeostasis during Metabolic
   Stress
SO MOLECULAR AND CELLULAR BIOLOGY
LA English
DT Article
ID ACTIVATED PROTEIN-KINASE; MOUSE SKELETAL-MUSCLE; GLUCOSE-TRANSPORT;
   INSULIN-RESISTANCE; GLYCOGEN-SYNTHASE; DIRECT PHOSPHORYLATION; CATALYTIC
   SUBUNIT; LIPID-METABOLISM; EXERCISE; METFORMIN
AB AMP activated protein kinase (AMPK) plays a key role in the regulatory network responsible for maintaining systemic energy homeostasis during exercise or nutrient deprivation. To understand the function of the regulatory beta 2 subunit of AMPK in systemic energy metabolism, we characterized beta 2 subunit-deficient mice. Using these mutant mice, we demonstrated that the beta 2 subunit plays an important role in regulating glucose, glycogen, and lipid metabolism during metabolic stress. The beta 2 mutant animals failed to maintain euglycemia and muscle ATP levels during fasting. In addition, beta 2-deficient animals showed classic symptoms of metabolic syndrome, including hyperglycemia, glucose intolerance, and insulin resistance when maintained on a high-fat diet (HFD), and were unable to maintain muscle ATP levels during exercise. Cell surface-associated glucose transporter levels were reduced in skeletal muscle from beta 2 mutant animals on an HFD. In addition, they displayed poor exercise performance and impaired muscle glycogen metabolism. These mutant mice had decreased activation of AMPK and deficits in PGC1 alpha-mediated transcription in skeletal muscle. Our results highlight specific roles of AMPK complexes containing the beta 2 subunit and suggest the potential utility of AMPK isoform-specific pharmacological modulators for treatment of metabolic, cardiac, and neurological disorders.
C1 [Dasgupta, Biplab; Liu, Xiaona] Cincinnati Childrens Hosp Med Ctr, Dept Pediat, Div Hematol & Oncol, Cincinnati, OH USA.
   [Lindquist, Diana] Cincinnati Childrens Hosp Med Ctr, Imaging Res Ctr, Dept Radiol, Cincinnati, OH USA.
   [Ju, Jeong Sun] Washington Univ, Sch Med, Dept Neurol, St Louis, MO 63110 USA.
   [Jung, Su-Ryun; Higashida, Kazuhiko] Washington Univ, Sch Med, Dept Internal Med, St Louis, MO 63110 USA.
   [Sasaki, Yo; Milbrandt, Jeffrey] Washington Univ, Sch Med, Dept Genet, St Louis, MO 63110 USA.
   [Sasaki, Yo; Milbrandt, Jeffrey] Washington Univ, Sch Med, HOPE Ctr Neurol Disorders, St Louis, MO USA.
C3 Cincinnati Children's Hospital Medical Center; Cincinnati Children's
   Hospital Medical Center; Washington University (WUSTL); Washington
   University (WUSTL); Washington University (WUSTL); Washington University
   (WUSTL)
RP Dasgupta, B (corresponding author), Cincinnati Childrens Hosp Med Ctr, Dept Pediat, Div Hematol & Oncol, Cincinnati, OH USA.
EM biplab.dasgupta@cchmc.org; jmilbrandt@wustl.edu
RI liu, xiaona/G-5834-2013
OI Milbrandt, Jeffrey/0000-0002-5477-7689; Ju,
   Jeong-sun/0000-0001-7276-9941
FU National Institutes of Health (NIH) [NS057105, P30 DK56341, AG13730,
   NS040745]; HOPE Center for Neurological Disorders; Division of
   Hematology and Oncology, Cincinnati Children's Hospital Medical Center
FX This work was supported by National Institutes of Health (NIH)
   Neuroscience Blueprint Core Grant NS057105 (to Washington University),
   NIH grant P30 DK56341 to the CNRU, the HOPE Center for Neurological
   Disorders, and NIH grants AG13730 and NS040745 (to J.M.) and by the
   Division of Hematology and Oncology, Cincinnati Children's Hospital
   Medical Center (to B.D.).
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NR 57
TC 51
Z9 61
U1 1
U2 16
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0270-7306
J9 MOL CELL BIOL
JI Mol. Cell. Biol.
PD JUL
PY 2012
VL 32
IS 14
BP 2837
EP 2848
DI 10.1128/MCB.05853-11
PG 12
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA 972AR
UT WOS:000306249400017
PM 22586267
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Núñez-Córdoba, JM
   Martínez-González, MA
AF Nunez-Cordoba, Jorge M.
   Martinez-Gonzalez, Miguel A.
TI Antioxidant Vitamins and Cardiovascular Disease
SO CURRENT TOPICS IN MEDICINAL CHEMISTRY
LA English
DT Review
DE Natural antioxidants; vitamin E; vitamin C; ascorbic acid;
   beta-carotene; cardiovascular disease; coronary heart disease;
   myocardial infarction; ischeamic heart disease; stroke; cerebrovascular
   disease
ID CORONARY-HEART-DISEASE; MEDITERRANEAN-STYLE DIET; BETA-CAROTENE;
   VEGETABLE CONSUMPTION; BLOOD-PRESSURE; RISK-FACTORS; FOLLOW-UP;
   MYOCARDIAL-INFARCTION; NUTRITIONAL FACTORS; METABOLIC SYNDROME
AB Cardiovascular disease represents an unparalleled proportion of the global burden of disease and will remain the main cause of mortality for the near future. Fortunately, most premature cardiovascular deaths are preventable. Therefore, prevention becomes vital and diet has shown beneficial effects to protect from CVD (CVD). Fruits and vegetables are dietary sources of natural antioxidants and it is generally accepted that antioxidants in these foods are key in explaining the inverse association between fruits and vegetables intake and the risk of developing a cardiovascular event or having elevated levels of cardiovascular risk factors. Available evidence supports the central role of oxidative stress in the atherosclerosis process and the correlation between increased oxidative stress and vascular disease. Theoretically, antioxidants in fruits and vegetables are important in inhibiting oxidative mechanisms that lead to various degenerative diseases including CVD. However, results from many interventional trials using antioxidants given as supplements have not been concordant with previous positive findings from observational epidemiologic cohort studies. The present manuscript gives a brief overview of the relationship between natural antioxidants (specially vitamin C, vitamin E and beta-carotene) intake and the risk of CVD.
C1 [Nunez-Cordoba, Jorge M.] Univ Navarra Clin, Prevent Med Unit, Pamplona 31008, Spain.
   [Nunez-Cordoba, Jorge M.; Martinez-Gonzalez, Miguel A.] Univ Navarra Clin, Sch Med, Dept Prevent Med & Publ Hlth, Pamplona 31008, Spain.
C3 University of Navarra; University of Navarra
RP Núñez-Córdoba, JM (corresponding author), Univ Navarra Clin, Prevent Med Unit, Avda Pio XII 36, Pamplona 31008, Spain.
EM jorge.nun@gmail.com
RI Martinez-Gonzalez, Miguel/AAE-7669-2019
OI Martinez-Gonzalez, Miguel A./0000-0002-3917-9808
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NR 105
TC 44
Z9 52
U1 0
U2 34
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1568-0266
EI 1873-5294
J9 CURR TOP MED CHEM
JI Curr. Top. Med. Chem.
PD JUL
PY 2011
VL 11
IS 14
BP 1861
EP 1869
PG 9
WC Chemistry, Medicinal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 792PO
UT WOS:000292759700010
PM 21506930
DA 2025-06-11
ER

PT J
AU Shin, MJ
   Park, E
AF Shin, Min-Jeong
   Park, Eunju
TI Plasma levels of leptin are associated with the plasma levels of LDL
   conjugated dienes in children
SO ANNALS OF NUTRITION AND METABOLISM
LA English
DT Article
DE leptin; conjugated diene; LDL oxidation; antioxidant vitamins
ID BODY-FAT DISTRIBUTION; INSULIN-RESISTANCE; METABOLIC SYNDROME; OXIDATIVE
   STRESS; OXIDIZED LDL; ENDOTHELIAL-CELLS; ALPHA-TOCOPHEROL; OBESE
   CHILDREN; PROTEIN-KINASE; BETA-CAROTENE
AB Background: Plasma leptin has been suggested to be involved in the proatherogenic process by increasing oxidative stress. We investigated the relationship between leptin and plasma conjugated diene formation, a measure of LDL oxidation in vivo in schoolchildren. Methods: We measured blood lipid profiles, plasma antioxidant vitamins, leptin and diene conjugation in LDL of 118 Korean children (35 overweight-obese vs. 83 normal weight children). Results: The overweight-obese children showed significantly higher levels of leptin (p < 0.0001), conjugated dienes (p = 0.02), total cholesterol (p < 0.05), triglyceride (p < 0.005) and LDL cholesterol (p < 0.01) and a significantly lower level of plasma lycopene (p < 0.0001) compared with the normal weight children. When all the subjects were classified into the three groups by tertiles of leptin levels, significant differences in circulating conjugated dienes (p < 0.05), lipid-corrected lycopene (p < 0.05), total cholesterol (p < 0.05), triglyceride (p < 0.05) and LDL cholesterol (p < 0.05) were found among the three groups. Conclusion: Our results showed that leptin was positively associated with the LDL conjugated diene formation, which might be related to the proatherogenic process in schoolchildren.
C1 Kyungnam Univ, Dept Food & Nutr, Masan 631701, South Korea.
   Yonsei Univ, Coll Med, Yonsei Cardiovasc Res Inst, Seoul 120749, South Korea.
C3 Kyungnam University; Yonsei University; Yonsei University Health System
RP Park, E (corresponding author), Kyungnam Univ, Dept Food & Nutr, Masan 631701, South Korea.
EM pej@kyungnam.ac.kr
RI Park, Eunju/AAF-9669-2021; Shin, Minjeong/HTT-0324-2023
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NR 41
TC 6
Z9 6
U1 0
U2 1
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0250-6807
EI 1421-9697
J9 ANN NUTR METAB
JI Ann. Nutr. Metab.
PY 2007
VL 51
IS 1
BP 1
EP 6
DI 10.1159/000099010
PG 6
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 163PR
UT WOS:000246173700001
PM 17259698
DA 2025-06-11
ER

PT J
AU Gu, WY
   Zhao, JJ
   Xu, Y
AF Gu, Wenyi
   Zhao, Jiajing
   Xu, Yu
TI Hyperuricemia-induced complications: dysfunctional macrophages serve as
   a potential bridge
SO FRONTIERS IN IMMUNOLOGY
LA English
DT Review
DE hyperuricemia; inflammation; macrophage; treatment; oxidative stress
ID SERUM URIC-ACID; CRYSTAL-INDUCED INFLAMMATION; ASYMPTOMATIC
   HYPERURICEMIA; NLRP3 INFLAMMASOME; XANTHINE-OXIDASE; GOUTY-ARTHRITIS;
   DASH DIET; URATE; ACTIVATION; CELLS
AB With the changes in modern life, hyperuricemia (HUA) has become a serious universal health issue, leading to rising morbidity and mortality. Characterized by elevated levels of UA, HUA has become an independent risk factor for gout, chronic kidney disease, insulin resistance, cardiovascular disease, nonalcoholic fatty liver disease, etc. As HUA is a metabolic syndrome, the immune response is likely to play an active role throughout the whole process. Moreover, macrophages, as an indispensable component of the immune system, may serve as a promising target for addressing hyperuricemia-induced inflammation. Along with their precursor cells, monocytes, macrophages play a key role in the pathogenesis of HUA, primarily through three specific aspects, all of which are associated with inflammatory cytokines. The first mechanism involves direct action on urate transporters, such as URAT1 and ABCG2. The second mechanism is the modulation of inflammation, including targeting toll-like receptors (TLRs) and the NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome. The third mechanism pertains to the effects on oxidative stress mediators. In this review, we summarize the underlying mechanisms of hyperuricemia, focusing on the effects of macrophages, therapeutic approaches, and clinical trials addressing hyperuricemia-caused dysfunction. Additionally, we highlight directions for future development, aiming to support future theoretical studies.
C1 [Gu, Wenyi; Zhao, Jiajing; Xu, Yu] Shanghai Putuo Hosp Tradit Chinese Med, Dept Tradit Chinese Med, Shanghai, Peoples R China.
   [Gu, Wenyi; Xu, Yu] Shanghai Univ Tradit Chinese Med, Sch Pharm, Shanghai, Peoples R China.
   [Xu, Yu] Shanghai Univ Tradit Chinese Med, Engn Res Ctr, Shanghai Coll Tradit Chinese Med New Drug Discover, Shanghai, Peoples R China.
C3 Shanghai University of Traditional Chinese Medicine; Shanghai University
   of Traditional Chinese Medicine
RP Zhao, JJ; Xu, Y (corresponding author), Shanghai Putuo Hosp Tradit Chinese Med, Dept Tradit Chinese Med, Shanghai, Peoples R China.; Xu, Y (corresponding author), Shanghai Univ Tradit Chinese Med, Sch Pharm, Shanghai, Peoples R China.; Xu, Y (corresponding author), Shanghai Univ Tradit Chinese Med, Engn Res Ctr, Shanghai Coll Tradit Chinese Med New Drug Discover, Shanghai, Peoples R China.
EM zhaojiajingrose@163.com; xyzjh2021@shutcm.edu.cn
RI Zhao, Jiajing/HZI-1969-2023
FU Shanghai Putuo District Health System Technology Innovation Project
   [ptkwws202401]; Launch Fee for Talent Introduction and Research at
   Shanghai University of Traditional Chinese Medicine [A1U23205020411]
FX The author(s) declare financial support was received for the research,
   authorship, and/or publication of this article. This work was supported
   by the Shanghai Putuo District Health System Technology Innovation
   Project (ptkwws202401) and the Launch Fee for Talent Introduction and
   Research at Shanghai University of Traditional Chinese Medicine
   (A1U23205020411).
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NR 209
TC 0
Z9 0
U1 14
U2 14
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-3224
J9 FRONT IMMUNOL
JI Front. Immunol.
PD JAN 28
PY 2025
VL 16
AR 1512093
DI 10.3389/fimmu.2025.1512093
PG 22
WC Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology
GA W2V8F
UT WOS:001417224500001
PM 39935474
OA gold
DA 2025-06-11
ER

PT J
AU Rogers, SC
   Zhang, XM
   Azhar, G
   Luo, SK
   Wei, JY
AF Rogers, Steven C.
   Zhang, Xiaomin
   Azhar, Gohar
   Luo, Shaoke
   Wei, Jeanne Y.
TI Exposure to High or Low Glucose Levels Accelerates the Appearance of
   Markers of Endothelial Cell Senescence and Induces Dysregulation of
   Nitric Oxide Synthase
SO JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL
   SCIENCES
LA English
DT Article
DE Endothelial cell senescence; Low glucose; High glucose
ID OXIDATIVE STRESS; DEPENDENT VASODILATION; ACUTE HYPERGLYCEMIA; METABOLIC
   SYNDROME; DIABETES-MELLITUS; GLYCEMIC CONTROL; DYSFUNCTION;
   HYPOGLYCEMIA; DISEASE; HEART
AB To test the hypothesis that aging impairs endothelial cell response to glucose stress, we utilized a human umbilical vein endothelial cell in vitro model in which clinically relevant concentrations of normal (5.5mM), high (25mM), and low (1.5mM) glucose were tested. With advancing population doubling, exposure to normal glucose gradually decreased endothelial nitric oxide synthase expression and activity, resulting in slow, progressive development of markers of cell senescence (by population doubling level [PDL] 44). High or low glucose treatment accelerated the appearance of markers of senescence (by similar to PDL 35) along with declines in endothelial nitric oxide synthase expression and activity. Human umbilical vein endothelial cells exposed to alternating low and high glucose gave even more rapid acceleration in the appearance of markers of senescence (by similar to PDL 18) and reduction in endothelial nitric oxide synthase levels. Thus, exposure to low and high glucose induces earlier appearance of markers of endothelial cell senescence and dysregulation of the nitric oxide synthase gene and protein expression and function. These findings will help to elucidate endothelial dysfunction associated with glucose intolerance and improve future therapy for diabetic seniors.
C1 [Wei, Jeanne Y.] Univ Arkansas Med Sci, GRECC, CAVHS, Donald W Reynolds Inst Aging, Little Rock, AR 72205 USA.
   Univ Arkansas Med Sci, GRECC, CAVHS, Dept Geriatr, Little Rock, AR 72205 USA.
C3 Geriatric Research Education & Clinical Center; University of Arkansas
   System; University of Arkansas Medical Sciences; Geriatric Research
   Education & Clinical Center; University of Arkansas System; University
   of Arkansas Medical Sciences
RP Wei, JY (corresponding author), Univ Arkansas Med Sci, Reynolds Inst Aging, 629 Jack Stephens Dr, Little Rock, AR 72205 USA.
EM weijeanne@uams.edu
RI zhang, xiaomin/IQX-1078-2023
OI Zhang, Xiaomin/0000-0002-5660-5303
FU National Institutes of Health [AG028718]; GRECC; CAVHS; UAMS
FX This study was supported in part by National Institutes of Health
   (AG028718), GRECC, CAVHS, and UAMS.
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NR 60
TC 50
Z9 56
U1 4
U2 23
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1079-5006
EI 1758-535X
J9 J GERONTOL A-BIOL
JI J. Gerontol. Ser. A-Biol. Sci. Med. Sci.
PD DEC
PY 2013
VL 68
IS 12
BP 1469
EP 1481
DI 10.1093/gerona/glt033
PG 13
WC Geriatrics & Gerontology; Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA 248DX
UT WOS:000326675000003
PM 23585419
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Tessema, B
   Riemer, J
   Sack, U
   König, B
AF Tessema, Belay
   Riemer, Janine
   Sack, Ulrich
   Koenig, Brigitte
TI Cellular Stress Assay in Peripheral Blood Mononuclear Cells: Factors
   Influencing Its Results
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE cellular stress assay; peripheral blood mononuclear cells; mitochondrial
   function
ID OXIDATIVE STRESS; MITOCHONDRIAL DYSFUNCTION; METABOLIC SYNDROME;
   MONOCYTES
AB Cellular stress is central to the understanding of pathological mechanisms and the development of new therapeutic strategies and serves as a biomarker for disease progression in neurodegeneration, diabetes, cancer, cardiovascular and other chronic diseases. The common cellular stress assay (CSA) based on Seahorse technology in peripheral blood mononuclear cells (PBMCs) shows inconsistent results, which prevents its use as a biomarker for the progression of chronic diseases. Therefore, the aim of this study was to investigate potential factors that affect the CSA in PBMCs. We measured the CSA parameters in PBMCs from study participants and compared the results according to the potential factors, namely, the PBMC isolation method, age, seasonal variation and the gender of the study participants. PBMCs were isolated by OptiPrep (R) and Robosep (TM)-S methods. PBMCs isolated with the OptiPrep method showed much higher extracellular acidification and higher respiration compared to Robosep-isolated cells. Moreover, OptiPrep-isolated cells showed a higher number of outliers for the proton production rate (PPR) and a high respiratory quotient, indicating impurities with other cells, such as platelets, and technical inconsistencies. PBMCs from older individuals showed higher maximal respiration, spare capacity and extracellular acidification than younger participants. Additionally, in winter, maximal respiration and spare capacity decreased. From spring until early autumn, spare capacity and maximal respiration continuously increased. Elderly males also showed higher basal respiration, spare capacity and extracellular acidification than females. In conclusion, the findings of this study clearly demonstrate that the results of CSA parameters measured in PBMCs are influenced by the PBMC isolation method, age, seasonal variation and gender. Therefore, we recommend that researchers and physicians properly interpret the results of CSA parameters in PBMCs by considering these factors. It is important to use separate CSA evaluation standards based on the isolation method, age, gender and season-dependent factors. To assess the cellular stress situation in PBMCs, both extracellular acidification and mitochondrial respiration should be taken into account. Further study of additional factors, such as mitochondrial mass, should be conducted to improve the measurement of CSA parameters for the assessment of the real mitochondrial fitness.
C1 [Tessema, Belay; Sack, Ulrich] Univ Leipzig, Fac Med, Inst Clin Immunol, D-04103 Leipzig, Germany.
   [Tessema, Belay] Univ Gondar, Coll Med & Hlth Sci, Dept Med Microbiol, Gondar 196, Ethiopia.
   [Riemer, Janine; Koenig, Brigitte] Magdeburg Mol Detect GmbH & Co KG, D-39104 Magdeburg, Germany.
   [Koenig, Brigitte] Univ Leipzig, Fac Med, Inst Med Microbiol & Virol, D-04103 Leipzig, Germany.
C3 Leipzig University; University of Gondar; Leipzig University
RP Tessema, B (corresponding author), Univ Leipzig, Fac Med, Inst Clin Immunol, D-04103 Leipzig, Germany.; Tessema, B (corresponding author), Univ Gondar, Coll Med & Hlth Sci, Dept Med Microbiol, Gondar 196, Ethiopia.
EM bt1488@yahoo.com
RI Tes, Bel/L-3858-2019; Sack, Ulrich/J-6301-2015
OI Tessema, Belay/0000-0003-1475-7357; Konig, Brigitte/0000-0002-5073-3849
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NR 44
TC 6
Z9 6
U1 2
U2 6
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD NOV
PY 2022
VL 23
IS 21
AR 13118
DI 10.3390/ijms232113118
PG 20
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 6B2XH
UT WOS:000881201800001
PM 36361904
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Ge, WH
   Sun, Q
   Yang, YX
   Ding, Z
   Liu, JH
   Zhang, JF
AF Ge, Wenhao
   Sun, Qi
   Yang, Yunxia
   Ding, Zhao
   Liu, Junhao
   Zhang, Jianfa
TI Circadian PER1 controls daily fat absorption with the regulation of
   PER1-PKA on phosphorylation of bile acid synthetase
SO JOURNAL OF LIPID RESEARCH
LA English
DT Article
ID CHOLESTEROL 7-ALPHA-HYDROXYLASE; METABOLIC SYNDROME; DIURNAL-VARIATION;
   IN-VIVO; CLOCK; GENE; PROTEIN; OBESITY; LIVER; EXPRESSION
AB Several epidemiological studies suggest a correlation between eating time and obesity. Night eating syndrome characterized by a time-delayed eating pattern is positively associated with obesity in humans as well as in experimental animals. Here, we show that oil intake at night significantly makes more fat than that at day in wild-type mice, and circadian Period 1 (Per1) contributes to this day-night difference. Per1-knockout mice are protected from high-fat diet-induced obesity, which is accompanied by a reduction in the size of the bile acid pool, and the oral administration of bile acids restores fat absorption and accumulation. We identify that PER1 directly binds to the major hepatic enzymes involved in bile acid synthesis such as cholesterol 7alpha-hydroxylase and sterol 12alpha-hydroxylase. A biosynthesis rhythm of bile acids is accompanied by the activity and instability of bile acid synthases with PER1/PKA-mediated phosphorylation pathways. Both fasting and high fat stress enhance Per1expression, increasing the fat absorption and accumulation. Our findings reveal that Per1is an energy regulator and controls daily fat absorption and accumulation. Circadian Per1controls daily fat absorption and accumulation, suggesting Per1 is a potential candidate of a key regulator in stress response and the relevant obesity risk.
C1 [Ge, Wenhao; Yang, Yunxia; Ding, Zhao; Liu, Junhao; Zhang, Jianfa] Nanjing Univ Sci & Technol, Ctr Mol Metab, Nanjing, Peoples R China.
   [Sun, Qi] Bengbu Med Coll, Key Lab Cardiovasc & Cerebrovasc Dis, Bengbu, Peoples R China.
C3 Nanjing University of Science & Technology; Bengbu Medical University
RP Zhang, JF (corresponding author), Nanjing Univ Sci & Technol, Ctr Mol Metab, Nanjing, Peoples R China.
EM jfzhang@mail.njust.edu.cn
RI Ding, Zhao/AAB-7187-2019
OI Sun, Qi/0009-0009-0572-9822; Liu, Junhao/0000-0002-5797-4469
FU National Natural Science Foundation of China [31871178, 32000822]; China
   Postdoctoral Science Foundation [2022M721632]
FX Funding and additional information This work was supported by the grant
   from the National Natural Science Foundation of China (numbers 31871178,
   32000822) ; China Postdoctoral Science Foundation (numbers 2022M721632)
   . J. F. Z. is the guarantor of this work and, as such, had full access
   to all the data in the study and takes responsibility for the integrity
   of the data and the accuracy of the data analysis.
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NR 67
TC 6
Z9 7
U1 1
U2 15
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0022-2275
EI 1539-7262
J9 J LIPID RES
JI J. Lipid Res.
PD JUN
PY 2023
VL 64
IS 6
AR 100390
DI 10.1016/j.jlr.2023.100390
EA JUN 2023
PG 14
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA L7QV9
UT WOS:001025178500001
PM 37209828
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Zhang, JQ
   Yan, EF
   Zhang, LL
   Wang, T
   Wang, C
AF Zhang, Jiaqi
   Yan, Enfa
   Zhang, Lili
   Wang, Tian
   Wang, Chao
TI Curcumin reduces oxidative stress and fat deposition in longissimus
   dorsi muscle of intrauterine growth-retarded finishing pigs
SO ANIMAL SCIENCE JOURNAL
LA English
DT Article
DE curcumin; finishing pigs; intrauterine growth retardation; longissimus
   dorsi muscle
ID MEAT QUALITY; ANTIOXIDANT CAPACITY; METABOLIC SYNDROME; BIRTH-WEIGHT;
   GENE; RETARDATION; PERFORMANCE; EXPRESSION; PIGLETS; PATHWAY
AB Dietary curcumin possessing multiple biological activities may be an effective way to alleviate oxidative damage and fat deposition in intrauterine growth retardation (IUGR) finishing pigs. Therefore, this study was conducted to evaluate effects of dietary curcumin on meat quality, antioxidant capacity, and fat deposition of longissimus dorsi muscle in IUGR finishing pigs. Twelve normal birth weight (NBW) and 24 IUGR female piglets at 26 days of age were divided into 3 dietary groups: NBW (basal diet), IUGR (basal diet), and IUGR + Cur (basal diet supplemented with 200 mg/kg curcumin). The trial lasted for 169 days. Results showed that IUGR increased concentrations of malondialdehyde (MDA) and protein carbonyls (PC) and fat deposition in longissimus dorsi muscle. However, curcumin decreased the intramuscular fat content and the levels of MDA and PC and improved meat quality in IUGR pigs. Furthermore, curcumin inhibited the decrease of nuclear factor erythroid 2-related factor 2 (Nrf2) protein expression and decreased peroxisome pro liferator-activated receptors gamma (PPAR gamma) expression in IUGR pigs. These findings suggested that dietary addition of 200 mg/kg curcumin could improve meat quality, alleviate oxidative stress through activating Nrf2 signaling pathway, and reduce fat deposition via inhibiting PPAR gamma expression in longissimus dorsi muscle of IUGR finishing pigs.
C1 [Zhang, Jiaqi; Yan, Enfa; Zhang, Lili; Wang, Tian; Wang, Chao] Nanjing Agr Univ, Coll Anim Sci & Technol, Natl Expt Teaching Demonstrat Ctr Anim Sci, Nanjing 210095, Peoples R China.
C3 Nanjing Agricultural University
RP Wang, C (corresponding author), Nanjing Agr Univ, Coll Anim Sci & Technol, Natl Expt Teaching Demonstrat Ctr Anim Sci, Nanjing 210095, Peoples R China.
EM wangchao121@njau.edu.cn
RI jiaqi, zhang/AAH-2609-2021
FU National Natural Science Foundation of China [31601948, 31972598,
   31772634]
FX This work was financially supported by the National Natural Science
   Foundation of China (No. 31601948, No. 31972598, and No. 31772634). The
   authors thank all co-workers for their help and cooperation in this
   trial.
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NR 71
TC 8
Z9 10
U1 5
U2 18
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1344-3941
EI 1740-0929
J9 ANIM SCI J
JI Anim. Sci. J.
PD JAN
PY 2022
VL 93
IS 1
AR e13741
DI 10.1111/asj.13741
PG 13
WC Agriculture, Dairy & Animal Science
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture
GA 2E5RH
UT WOS:000812284600001
PM 35707899
DA 2025-06-11
ER

PT J
AU Ross, MM
   Piorczynski, TB
   Harvey, J
   Burnham, TS
   Francis, M
   Larsen, MW
   Roe, K
   Hansen, JM
   Stark, MR
AF Ross, Micah M.
   Piorczynski, Ted B.
   Harvey, Jamison
   Burnham, Tyson S.
   Francis, Morgan
   Larsen, Madison W.
   Roe, Kyle
   Hansen, Jason M.
   Stark, Michael R.
TI Ceramide: a novel inducer for neural tube defects
SO DEVELOPMENTAL DYNAMICS
LA English
DT Article
DE birth defects; ceramide; maternal obesity; neural tube defects;
   oxidative stress; teratogen
ID OXIDATIVE STRESS; LIPID RAFTS; FOLIC-ACID; INSULIN SENSITIVITY; DIABETIC
   PREGNANCY; METABOLIC SYNDROME; MATERNAL OBESITY; GENE-EXPRESSION; CELL
   APOPTOSIS; PRIMARY CILIA
AB Background Circulating plasma ceramides, a class of bioactive sphingolipids, are elevated in metabolic disorders, including obesity. Infants of women with these disorders are at 2- to 3-fold greater risk for developing a neural tube defect (NTD). This study aimed to test the effects of embryonic exposure to C2-ceramides (C2) during neural tube closure. Preliminary data shows an increase in NTDs in chick embryos after C2 exposure, and addresses potential mechanisms. Results Cell and embryo models were used to examine redox shifts after ceramide exposure. While undifferentiated P19 cells were resistant to ceramide exposure, neuronally differentiated P19 cells exhibited an oxidizing shift. Consistent with these observations, GSH E-h curves revealed a shift to a more oxidized state in C2 treated embryos without increasing apoptosis or changing Pax3 expression, however cell proliferation was lower. Neural tube defects were observed in 45% of chick embryos exposed to C2, compared to 12% in control embryos. Conclusions C2 exposure during critical developmental stages increased the frequency of NTDs in the avian model. Increased ROS generation in cell culture, along with the more oxidative GSH E-h profiles of C2 exposed cells and embryos, support a model wherein ceramide affects neural tube closure via altered tissue redox environments.
C1 [Ross, Micah M.; Piorczynski, Ted B.; Harvey, Jamison; Burnham, Tyson S.; Francis, Morgan; Larsen, Madison W.; Roe, Kyle; Hansen, Jason M.; Stark, Michael R.] Brigham Young Univ, Coll Life Sci, Dept Physiol & Dev Biol, Provo, UT 84602 USA.
C3 Brigham Young University
RP Stark, MR (corresponding author), Brigham Young Univ, 3066 LSB, Provo, UT 84001 USA.
EM michael_stark@byu.edu
RI Roe, Kyle/KWU-5431-2024
OI Piorczynski, Ted/0000-0002-8494-9277; Larsen,
   Madison/0000-0001-9184-0889
FU Brigham Young University
FX The authors thank Ben Bikman for his expertise on ceramide, Julie Goudy
   for early work on the project, several undergraduate students, including
   Emarie Covey and Yeram Park, for their work on various experiments, and
   Brigham Young University for graciously funding this project.
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NR 89
TC 6
Z9 8
U1 0
U2 9
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1058-8388
EI 1097-0177
J9 DEV DYNAM
JI Dev. Dyn.
PD OCT
PY 2019
VL 248
IS 10
BP 979
EP 996
DI 10.1002/dvdy.93
EA AUG 2019
PG 18
WC Anatomy & Morphology; Developmental Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Anatomy & Morphology; Developmental Biology
GA JB8FV
UT WOS:000483981100001
PM 31390103
OA Bronze
DA 2025-06-11
ER

PT J
AU Zheng, T
   Yang, XY
   Li, WJ
   Wang, QB
   Chen, L
   Wu, D
   Bian, F
   Xing, SS
   Jin, S
AF Zheng, Tao
   Yang, Xiaoyan
   Li, Wenjin
   Wang, Qibin
   Chen, Li
   Wu, Dan
   Bian, Fang
   Xing, Shasha
   Jin, Si
TI Salidroside Attenuates High-Fat Diet-Induced Nonalcoholic Fatty Liver
   Disease via AMPK-Dependent TXNIP/NLRP3 Pathway
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Article
ID THIOREDOXIN-INTERACTING PROTEIN; NLRP3 INFLAMMASOME ACTIVATION;
   ELEMENT-BINDING PROTEIN; INSULIN-RESISTANCE; METABOLIC SYNDROME; RAT
   MODEL; GLUCOSE; EXPRESSION; MECHANISM; NAFLD
AB Our previous studies suggested that salidroside could alleviate hepatic steatosis in type 2 diabetic C57BLKS/Lepr(db) (db/db) mice. The aim of the present study was to evaluate the therapeutic effect of salidroside on high-fat diet- (HFD-) induced nonalcoholic fatty liver disease (NAFLD) by investigating underlying mechanisms. Mice were fed with HFD or regular diet, randomly divided into two groups, and treated with salidroside or vehicle for 8 weeks. Then, biochemical analyses and histopathological examinations were conducted in vivo and in vitro. Salidroside administration attenuated HFD-induced obesity, blood glucose variability, and hepatic lipid deposition, markedly increasing insulin sensitivity in HFD mice. In addition, salidroside suppressed oxidative stress, thioredoxin-interacting protein (TXNIP) expression, and NLRP3 inflammasome activation in the liver. In cultured hepatocytes, salidroside dose dependently regulated lipid accumulation, reactive oxygen species (ROS) generation, and NLRP3 inflammasome activation as well as improved AMP-activated protein kinase (AMPK) activity and insulin sensitivity. The inhibition of AMPK activation by inhibitor or short interfering RNA (siRNA) resulted in the suppression of the beneficial effects of salidroside in hepatocytes. Our findings demonstrated that salidroside protects against NAFLD by improving hepatic lipid metabolism and NLRP3 inflammasome activation, and these actions are related to the regulation of the oxidative stress and AMPK-dependent TXNIP/NLRP3 pathways.
C1 [Zheng, Tao; Li, Wenjin; Wu, Dan; Bian, Fang; Xing, Shasha; Jin, Si] Huazhong Univ Sci & Technol, Tongji Med Coll, Liyuan Hosp, Inst Geriatr Med, Wuhan, Hubei, Peoples R China.
   [Zheng, Tao; Wang, Qibin; Chen, Li] Hubei Univ Med, Taihe Hosp, Dept Pharm, Shiyan, Hubei, Peoples R China.
   [Zheng, Tao; Yang, Xiaoyan; Li, Wenjin; Wu, Dan; Bian, Fang; Xing, Shasha; Jin, Si] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Basic Med,Dept Pharmacol, Hubei Key Lab Drug Target Res & Pharmacodynam Eva, Wuhan, Hubei, Peoples R China.
   [Zheng, Tao; Wang, Qibin; Chen, Li] Xi An Jiao Tong Univ, Sch Med, Taihe Hosp, Shiyan, Hubei, Peoples R China.
   [Jin, Si] Huazhong Univ Sci & Technol, Tongji Med Coll, Liyuan Hosp, Dept Endocrinol, Wuhan, Hubei, Peoples R China.
C3 Huazhong University of Science & Technology; Hubei University of
   Medicine; Huazhong University of Science & Technology; Xi'an Jiaotong
   University; Huazhong University of Science & Technology
RP Jin, S (corresponding author), Huazhong Univ Sci & Technol, Tongji Med Coll, Liyuan Hosp, Inst Geriatr Med, Wuhan, Hubei, Peoples R China.; Jin, S (corresponding author), Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Basic Med,Dept Pharmacol, Hubei Key Lab Drug Target Res & Pharmacodynam Eva, Wuhan, Hubei, Peoples R China.; Jin, S (corresponding author), Huazhong Univ Sci & Technol, Tongji Med Coll, Liyuan Hosp, Dept Endocrinol, Wuhan, Hubei, Peoples R China.
EM jinsi@hust.edu.cn
RI xing, shasha/JFB-2393-2023; Jin, Si/KGK-5977-2024; Yang,
   Xiaoyan/P-9080-2014; Zheng, Tao/JOZ-1467-2023
OI Zheng, Tao/0000-0003-1742-1357
FU National Natural Science Foundation of China [81573432, 81703582,
   81470458, 81373413]; Ministry of Education of China [NCET-10-0409];
   Hubei Provincial Natural Science Foundation of China [2016CFB153]
FX This work was supported by grants from the National Natural Science
   Foundation of China (81573432, 81703582, 81470458, and 81373413),
   Ministry of Education of China (NCET-10-0409), and Hubei Provincial
   Natural Science Foundation of China (2016CFB153).
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NR 55
TC 105
Z9 111
U1 0
U2 47
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PY 2018
VL 2018
AR 8597897
DI 10.1155/2018/8597897
PG 17
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA GP5JM
UT WOS:000440909700001
PM 30140371
OA Green Published, hybrid, Green Submitted
DA 2025-06-11
ER

PT J
AU Huang, CZ
   Tung, YT
   Hsia, SM
   Wu, CH
   Yen, GC
AF Huang, Cheng-Ze
   Tung, Yu-Tang
   Hsia, Shih-Min
   Wu, Chi-Hao
   Yen, Gow-Chin
TI The hepatoprotective effect of Phyllanthus emblica L. fruit on
   high fat diet-induced non-alcoholic fatty liver disease (NAFLD) in SD
   rats
SO FOOD & FUNCTION
LA English
DT Article
ID OXIDATIVE STRESS; OFFICINALIS GAERTN.; HEPATIC STEATOSIS; ACID;
   EXPRESSION; ALPHA; LIPOGENESIS; METABOLISM; NECROSIS; ENZYMES
AB Non-alcoholic fatty liver disease (NAFLD), the most common chronic liver disease, is closely associated with metabolic syndrome and refers to the accumulation of hepatic steatosis not due to excess alcohol consumption. Phyllanthus emblica L. is a rich source of gallic acid and many known medicinally phytochemicals such as tannins, lignans, flavonoids, alkaloids, vitamin C, mucic acid, and ellagic acid. Our previous study has revealed that P. emblica exhibits inhibitory effects on hepatic steatosis and liver fibrosis in vitro, as well as gallic acid improves high fat diet (HFD)-induced dyslipidaemia, hepatosteatosis, and oxidative stress in vivo. Therefore, the aim of this study was to investigate the hepatoprotective effect of the water extract of P. emblica L. fruit (WEPE) on NAFLD in an animal model. The results showed that WEPE could significantly decrease body weight, peritoneal fat and epididymal fat, enhance the antioxidant enzyme activities, and improve steatosis through elevating adiponectin in adipocytes and PPAR-alpha in the liver as well as lowering SREBP-1c in the liver of rats fed with a high fat diet (HFD). This might be an explanation for the hepatic fat deposition-lowering effect of WEPE. These results demonstrate that WEPE could be beneficial for the amelioration of HFD-induced steatosis.
C1 [Huang, Cheng-Ze; Tung, Yu-Tang; Yen, Gow-Chin] Natl Chung Hsing Univ, Dept Food Sci & Biotechnol, Taichung 40227, Taiwan.
   [Tung, Yu-Tang; Hsia, Shih-Min; Wu, Chi-Hao] Taipei Med Univ, Sch Nutr & Hlth Sci, 250 Wu Hsing St, Taipei 110, Taiwan.
C3 National Chung Hsing University; Taipei Medical University
RP Yen, GC (corresponding author), Natl Chung Hsing Univ, Dept Food Sci & Biotechnol, Taichung 40227, Taiwan.
EM gcyen@nchu.edu.tw
RI Hsia, Shih-Min/AAL-2026-2020; Yen, Gow-Chin/B-7886-2009; Wu,
   chihao/G-3512-2011
OI Hsia, Shih-Min/0000-0003-2888-2618; Tung, Yu-Tang/0000-0002-4780-6496;
   Yen, Gow-Chin/0000-0001-9538-4219; Wu, ChiHao/0000-0001-7243-3436
FU Council of Agriculture, Taiwan [101AS-3.1.3-FD-Z1(1)]; Ministry of
   Science and Technology, Taiwan [MOST103-2313-B-038-003-MY3]
FX This research work was supported in part by the Council of Agriculture,
   Taiwan, under grant 101AS-3.1.3-FD-Z1(1), and in part by the grant
   MOST103-2313-B-038-003-MY3 from the Ministry of Science and Technology,
   Taiwan. The authors thank Dr. J. W. Liao of the Graduate Institute of
   Veterinary Pathobiology for his technical assistance on histological
   examination.
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TC 70
Z9 77
U1 3
U2 61
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PD FEB 1
PY 2017
VL 8
IS 2
BP 842
EP 850
DI 10.1039/c6fo01585a
PG 9
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA EN2YE
UT WOS:000395875400038
PM 28128372
DA 2025-06-11
ER

PT J
AU Villagarcía, HG
   Sabugo, V
   Castro, MC
   Schinella, G
   Castrogiovanni, D
   Spinedi, E
   Massa, ML
   Francini, F
AF Gonzalo Villagarcia, Hernan
   Sabugo, Vanesa
   Cecilia Castro, Maria
   Schinella, Guillermo
   Castrogiovanni, Daniel
   Spinedi, Eduardo
   Laura Massa, Maria
   Francini, Flavio
TI Chronic Glucocorticoid-Rich Milieu and Liver Dysfunction
SO INTERNATIONAL JOURNAL OF ENDOCRINOLOGY
LA English
DT Article
ID MONOSODIUM L-GLUTAMATE; OXIDATIVE STRESS; MITOCHONDRIAL-FUNCTION;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; ARCUATE NUCLEUS; ADIPOSE-TISSUE;
   URIC-ACID; GLUCOSE; RATS
AB We investigated the impact of chronic hypercorticosteronemia (due to neonatal monosodium L-glutamate, MSG, and treatment) on liver oxidative stress (OS), inflammation, and carbohydrate/lipid metabolism in adult male rats. We evaluated the peripheral concentrations of several metabolic and OS markers and insulin resistance indexes. In liver we assessed (a) OS (GSH and protein carbonyl groups) and inflammatory (IL-1b, TNFa, and PAI-1) biomarkers and (b) carbohydrate and lipid metabolisms. MSG rats displayed degenerated optic nerves, hypophagia, low body and liver weights, and enlarged adipose tissue mass; higher peripheral levels of glucose, triglycerides, insulin, uric acid, leptin, corticosterone, transaminases and TBARS, and peripheral and liver insulin resistance; elevated liver OS, inflammation markers, and glucokinase (mRNA/activity) and fructokinase (mRNA). Additionally, MSG liver phosphofructokinase-2, glucose-6-phosphatase (mRNA and activity) and glucose-6-phosphate dehydrogenase, Chrebp, Srebp1c, fatty acid synthase, and glycerol-3-phosphate (mRNAs) were increased. In conclusion adult MSG rats developed an insulin-resistant state and increased OS and serious hepatic dysfunction characterized by inflammation and metabolic signs suggesting increased lipogenesis. These features, shared by both metabolic and Cushing's syndrome human phenotypes, support that a chronic glucocorticoid-rich endogenous environment mainly impacts on hepatic glucose cycle, displacing local metabolism to lipogenesis. Whether correcting the glucocorticoid-rich environment ameliorates such dysfunctions requires further investigation.
C1 [Gonzalo Villagarcia, Hernan; Sabugo, Vanesa; Cecilia Castro, Maria; Spinedi, Eduardo; Laura Massa, Maria; Francini, Flavio] Univ Nacl La Plata, CONICET, FCM, Ctr Endocrinol Expt & Aplicada CENEXA, RA-1900 La Plata, Buenos Aires, Argentina.
   [Schinella, Guillermo] Univ Nacl La Plata, Fac Ciencias Med, Catedra Farmacol Basica, RA-1900 La Plata, Buenos Aires, Argentina.
   [Schinella, Guillermo] CICPBA, RA-1900 La Plata, Buenos Aires, Argentina.
   [Castrogiovanni, Daniel] Univ Nacl La Plata, CONICET, CICPBA, Inst Multidisciplinario Biol Celular IMBICE, RA-1900 La Plata, Buenos Aires, Argentina.
C3 National University of La Plata; Consejo Nacional de Investigaciones
   Cientificas y Tecnicas (CONICET); National University of La Plata;
   National University of La Plata; Consejo Nacional de Investigaciones
   Cientificas y Tecnicas (CONICET)
RP Francini, F (corresponding author), Univ Nacl La Plata, CONICET, FCM, Ctr Endocrinol Expt & Aplicada CENEXA, RA-1900 La Plata, Buenos Aires, Argentina.
EM f_francini@yahoo.com
RI ; Schinella, Guillermo/V-9937-2018
OI CASTRO, MARIA CECILIA/0000-0003-0831-4111; Castrogiovanni, Daniel
   Cayetano/0000-0001-8080-8509; Schinella, Guillermo/0000-0001-9541-9688
FU National Research Council of Argentina (CONICET); CONICET
   [PIP-0371-2012]; Swiss Foundation for Studies on Endocrinology,
   Diabetology and Metabolism [FPREDM 062013]
FX The authors are grateful to Mrs. S. H. Rogers and Rebecca Doyle for
   careful paper edition/correction. Eduardo Spinedi, Maria Laura Massa,
   and Flavio Francini are Research Career Awardees from National Research
   Council of Argentina (CONICET). This work was partially supported by
   grants from CONICET (PIP-0371-2012) and the Swiss Foundation for Studies
   on Endocrinology, Diabetology and Metabolism (FPREDM 062013).
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NR 61
TC 8
Z9 9
U1 0
U2 6
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1687-8337
EI 1687-8345
J9 INT J ENDOCRINOL
JI Int. J. Endocrinol.
PY 2016
VL 2016
AR 7838290
DI 10.1155/2016/7838290
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA DU2YL
UT WOS:000382077400001
PM 27597864
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Brummett, BH
   Siegler, IC
   Rohe, WM
   Barefoot, JC
   Vitaliano, PP
   Surwit, RS
   Feinglos, MN
   Williams, RB
AF Brummett, BH
   Siegler, IC
   Rohe, WM
   Barefoot, JC
   Vitaliano, PP
   Surwit, RS
   Feinglos, MN
   Williams, RB
TI Neighborhood characteristics moderate effects of caregiving on glucose
   functioning
SO PSYCHOSOMATIC MEDICINE
LA English
DT Article
DE caregiving; glucose; neighborhood characteristics
ID CORONARY-HEART-DISEASE; OLDER-ADULTS; PSYCHOSOCIAL FACTORS; SOCIAL
   SUPPORT; GLYCOSYLATED HEMOGLOBIN; METABOLIC SYNDROME; DIABETES-MELLITUS;
   GLYCEMIC CONTROL; CARDIAC PATIENTS; CHRONIC STRESS
AB Objective: Adverse neighborhood environments and caregiving for a relative with dementia are both stressors that have been associated with poor health. The present study examined the extent to which three self-report measures of neighborhood characteristics interact with caregiving status (caregiver versus noncaregiver) to modify an important stress related health outcome: plasma glucose. Methods: The study sample consisted of 147 community recruited caregivers and 147 participants who did not have caregiving responsibilities. We hypothesized that negative neighborhood characteristics would magnify effects of caregiving on plasma glucose levels. Regression analyses were conducted to examine the interaction of three neighborhood characteristic measures with caregiving status in predicting fasting plasma glucose (FPG) and glycosylated hemoglobin concentration (HbA1c), with control for age, race, gender, relation to care recipient (spouse or relative), body mass index, income, and education. Results: Of the three neighborhood measures, the one reflecting crime concerns significantly moderated the effect of caregiving on FPG (p < .002) and HbA1c (p < .001). For participants with better neighborhood characteristics, caregivers and noncaregivers were similar with respect to indicators of glucose metabolism; however, for participants with worse neighborhood characteristics, caregivers had higher levels of FPG and HbA1c, as compared with noncaregivers. Conclusions: Poor health outcomes, such as impaired glucose control, may be found among caregivers who fear neighborhood crime.
C1 Duke Univ, Med Ctr, Dept Psychiat & Behav Med, Durham, NC 27710 USA.
   Univ N Carolina, Ctr Urban & Reg Studies, Chapel Hill, NC 27515 USA.
   Univ Washington, Dept Psychiat & Behav Sci, Seattle, WA 98195 USA.
C3 Duke University; University of North Carolina; University of North
   Carolina Chapel Hill; University of Washington; University of Washington
   Seattle
RP Brummett, BH (corresponding author), Duke Univ, Med Ctr, Dept Psychiat & Behav Med, Box 2969, Durham, NC 27710 USA.
EM brummett@duke.edu
RI Rohe, William/I-1940-2013; Vitaliano, Peter/K-2014-2019
OI Vitaliano, peter P./0000-0003-1598-0868
FU NCRR NIH HHS [M01RR30] Funding Source: Medline; NHLBI NIH HHS [P01
   HL036587] Funding Source: Medline; NIA NIH HHS [R01AG19605] Funding
   Source: Medline; NIMH NIH HHS [R01MH57663] Funding Source: Medline
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NR 45
TC 21
Z9 25
U1 0
U2 9
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3261 USA
SN 0033-3174
J9 PSYCHOSOM MED
JI Psychosom. Med.
PD SEP-OCT
PY 2005
VL 67
IS 5
BP 752
EP 758
DI 10.1097/01.psy.0000174171.24930.11
PG 7
WC Psychiatry; Psychology; Psychology, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry; Psychology
GA 970GT
UT WOS:000232294000012
PM 16204434
DA 2025-06-11
ER

PT J
AU Khan, DA
   Qayyum, S
   Saleem, S
   Khan, FA
AF Khan, D. A.
   Qayyum, S.
   Saleem, S.
   Khan, F. A.
TI Lead-induced oxidative stress adversely affects health of the
   occupational workers
SO TOXICOLOGY AND INDUSTRIAL HEALTH
LA English
DT Article
DE creatinine; CRP; industrial workers; Lead; LFT; MDA; oxidative stress
ID GAMMA-GLUTAMYL-TRANSFERASE; C-REACTIVE PROTEIN; BLOOD LEAD; CATALYTIC
   CONCENTRATION; CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; FUNCTION
   TESTS; URIC-ACID; SERUM; INHIBITION
AB Lead is a persistent toxic metal and associated with impairment of various body functions in occupational workers. The main objective was to determine the lead-induced oxidative stress and adverse health effects by biochemical markers in industrial workers. One hundred and forty-eight males consisting of 87 lead-exposed industrial workers and 61 controls were included. Blood lead level (BLL) was determined on a 3010B ESA lead analyzer. Blood complete counts were done on a hematology analyzer. Biochemical markers including serum uric acid, urea, creatinine, phosphate, alanine aminotransferase (ALT), and gamma glutamyltransferase (GGT) were measured on a Selectra E auto analyzer. Serum malondialdellyde (MDA) was measured spectrophotometrically and C-reactive protein (CRP) on Immulite-1000. Results revealed that lead-exposed workers had significantly high BLLs, median (range), 29.1 (9.0-61.1) mu g/dL compared with controls, 8.3 (1.0-21.7) mu g/dL. Oxidative stress (MDA, GGT) and inflammatory markers (high-sensitivity CRP) were significantly increased (P <= 0.05). Blood pressure was raised, whereas hemoglobin was decreased in exposed group (P <= 0.002). Serum urea, uric acid, phosphate, and ALT were significantly raised in lead-exposed workers (P <= 0.001). Serum albumin, total proteins, and glomerular filtration rate (GFR) were decreased. Blood lead showed a significant positive correlation with serum GGT (r = 0.63), MDA (r = 0.71), CRP (r = 0.75), urea (r = 0.34), creatinine (r = 0.51), and uric acid (r = 0.29) (P <= 0.01). It is concluded that lead exposure increases oxidative stress that correlates with adverse changes in hematological, renal, and hepatic function in the occupational workers. Elevated blood lead has positive correlation with oxidative stress, inflammatory and biochemical markers that might be used to detect impairment in the body function in lead exposed workers. Toxicology and Industrial Health 2008; 24: 611-618.
C1 [Khan, D. A.; Qayyum, S.; Khan, F. A.] Natl Univ Sci & Technol, Dept Pathol, Army Med Coll, Rawalpindi, Pakistan.
   [Saleem, S.] POF Hosp, Wah Cantt, Pakistan.
C3 National University of Sciences & Technology - Pakistan
RP Khan, DA (corresponding author), Natl Univ Sci & Technol, Dept Pathol, Army Med Coll, Abid Majeed Rd, Rawalpindi, Pakistan.
EM dilshad56@yahoo.com
FU Estimation of Lead Burden and its Toxic Effects on Occupational Exposed
   Workers [20-732/RD/06/2231]; Higher Education Commission (HEC) Pakistan
FX This study was a part of the Project No. 20-732/R&D/06/2231 entitled
   "Estimation of Lead Burden and its Toxic Effects on Occupational Exposed
   Workers" supported by Higher Education Commission (HEC) Pakistan.
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NR 51
TC 81
Z9 91
U1 0
U2 12
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0748-2337
EI 1477-0393
J9 TOXICOL IND HEALTH
JI Toxicol. Ind. Health
PD OCT
PY 2008
VL 24
IS 9
BP 611
EP 618
DI 10.1177/0748233708098127
PG 8
WC Public, Environmental & Occupational Health; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health; Toxicology
GA 395TD
UT WOS:000262545500007
PM 19106128
DA 2025-06-11
ER

PT J
AU Scalcon, MRR
   Waclawovsky, AJ
   Schuch, FB
   Speeckaert, MM
   Moresco, RN
AF Scalcon, Marcia Regina R.
   Waclawovsky, Aline J.
   Schuch, Felipe B.
   Speeckaert, Marijn M.
   Moresco, Rafael N.
TI Proteomic biomarkers in psoriatic arthritis
SO CLINICA CHIMICA ACTA
LA English
DT Review
DE Biomarkers; Chromatographic methods; Diagnosis; Proteomics; Psoriatic
   arthritis
ID MASS-SPECTROMETRY; METABOLIC SYNDROME; OXIDATIVE STRESS; SYNOVIAL-FLUID;
   EXPRESSION; PATHOGENESIS; PREVALENCE; INFLAMMATION; PROGRESSION;
   DIAGNOSIS
AB Psoriasis (PsO) is a chronic inflammatory skin disease that affects 2-3% of the adult population worldwide. Psoriatic arthritis (PsA) is a chronic inflammatory arthropathy that occurs in 20-30% of PsO patients. PsA is characterized by a heterogeneous clinical phenotype that makes diagnosis and treatment challenging. Currently, diagnosis is predominantly based on clinical findings, highlighting the need for reliable biomarkers to improve diagnostic precision, refine prognostic evaluations, and guide personalized therapeutic strategies. Recent advances in proteomic methodologies have provided novel insights into the pathophysiology and diagnosis of PsA. This review synthesizes the current evidence on protein biomarkers associated with PsA, focusing on nontargeted chromatographic proteomic approaches. These methodologies can enable comprehensive analysis of diverse biological specimens, facilitating the identification of candidate proteins that could be incorporated into targeted enzymatic and immunological panels for routine clinical practice in the future. Our review identified 72 isolated proteins and one protein combination with potential diagnostic utility for PsA, with particular emphasis on biomarkers such as NAD-dependent sirtuin-2 deacetylase (SIRT2), stress-induced phosphoprotein 1 (STIP1), and thymosin beta 4 (TMSB4X). Despite the growing interest in proteomic approaches for PsA, additional investigations with larger, well-stratified patient cohorts are necessary to validate these findings, establish robust diagnostic biomarkers, and facilitate their clinical implementation.
C1 [Scalcon, Marcia Regina R.] Univ Fed Santa Maria, Sch Med, Dept Clin Med, Santa Maria, Brazil.
   [Waclawovsky, Aline J.; Schuch, Felipe B.] Univ Fed Rio de Janeiro, Inst Psychiat, Rio De Janeiro, Brazil.
   [Schuch, Felipe B.] Univ Fed Santa Maria, Dept Sports Methods & Tech, Santa Maria, Brazil.
   [Speeckaert, Marijn M.] Ghent Univ Hosp, Dept Nephrol, Ghent, Belgium.
   [Moresco, Rafael N.] Univ Fed Santa Maria, Dept Clin & Toxicol Anal, Santa Maria, Brazil.
   [Schuch, Felipe B.] Univ Autonoma Chile, Fac Hlth Scientes, Providencia, Chile.
C3 Universidade Federal de Santa Maria (UFSM); Universidade Federal do Rio
   de Janeiro; Universidade Federal de Santa Maria (UFSM); Ghent
   University; Ghent University Hospital; Universidade Federal de Santa
   Maria (UFSM); Universidad Autonoma de Chile
RP Moresco, RN (corresponding author), Univ Fed Santa Maria, Ctr Ciencias Saude, Dept Anal Clin & Toxicol, Ave Roraima 1000,Predio 26,Sala 1216, BR-97105900 Santa Maria, RS, Brazil.
EM rnmoresco@ufsm.br
RI Schuch, Felipe/AAF-5028-2019; Speeckaert, Marijn/HPB-8611-2023; Moresco,
   Rafael/K-6118-2017
FU National Council for Scientific and Technological Development (CNPq,
   Brazil) [313379/2021-1]
FX RNM received a research productivity scholarship from the National
   Council for Scientific and Technological Development (CNPq, Brazil,
   number 313379/2021-1) .
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NR 57
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0009-8981
EI 1873-3492
J9 CLIN CHIM ACTA
JI Clin. Chim. Acta
PD MAY 15
PY 2025
VL 572
AR 120244
DI 10.1016/j.cca.2025.120244
EA MAR 2025
PG 7
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA 0SY7X
UT WOS:001455281800001
PM 40096904
DA 2025-06-11
ER

PT J
AU Meiliana, A
   Dewi, NM
   Defi, IR
   Rosdianto, AM
   Qiantori, AA
   Wijaya, A
AF Meiliana, Anna
   Dewi, Nurrani Mustika
   Defi, Irma Ruslina
   Rosdianto, Aziiz Mardanarian
   Qiantori, Adziqa Ammara
   Wijaya, Andi
TI Sarcopenic Obesity: The Underlying Molecular Pathophysiology and
   Prospect Therapies
SO INDONESIAN BIOMEDICAL JOURNAL
LA English
DT Review
DE aging; body composition; obesity; sarcopenia; skeletal muscle; metabolic
   syndrome
ID HUMAN SKELETAL-MUSCLE; CHAIN FATTY-ACIDS; GUT MICROBIOTA;
   INSULIN-RESISTANCE; ADIPOSE-TISSUE; OLDER-ADULTS; PHYSICAL FUNCTION;
   DIETARY-PROTEIN; GENE-EXPRESSION; FOOD-INTAKE
AB BACKGROUND: Age contributes to body composition alteration, rises a common disorder in elderly known as sarcopenic obesity (SO), which is characterized by the combination of obesity (excess fat mass) and sarcopenia (reduced skeletal muscle mass) clinical form and function. CONTENT: The primary cause of SO is insulin resistance. Glucose transporter 4 (GLUT4) dysfunction results in impaired fatty acids oxidation. Decreased muscle mass results in lower mitochondria number and volume. Both will increase oxidative stress. Together with altered myokines in SO, oxidative stress was promoted and lead to higher M1 macrophages and failure in autophagy. The pro-inflammatory condition and dysbiosis links SO to a variety of cardiometabolic conditions, including non-alcoholic fatty liver disease, type 2 diabetes, and cardiovascular disease. The mortality, comorbidities, cardiometabolic diseases, and disability or impairment of SO is higher compare to obesity or sarcopenia alone. Some treatments have been developed for SO including adequate dietary intake, vitamin D and antioxidant supplementation, and exercises. SUMMARY: SO is more prevalent among the elderly and has a significant negative impact on their quality of life. Therefore, maintaining muscle mass and strength as well as preventing obesity should be the key goals of initiatives to support healthy aging.
C1 [Meiliana, Anna] Univ Padjajaran, Fac Pharm, Dept Pharmacol & Clin Pharm, Sumedang Km 21, Jatinangor 45363, Indonesia.
   [Meiliana, Anna; Wijaya, Andi] Prodia Clin Lab, Jl Supratman 43, Bandung 40114, Indonesia.
   [Dewi, Nurrani Mustika; Wijaya, Andi] Prodia Educ & Res Inst, Jl Kramat Raya 150, Jakarta 10430, Indonesia.
   [Dewi, Nurrani Mustika] Univ Padjadjaran, Fac Pharm, Doctoral Program Pharm, Sumedang KM 21, Jatinangor 45363, Indonesia.
   [Defi, Irma Ruslina] Univ Padjadjaran, Hasan Sadikin Gen Hosp, Fac Med, Dept Phys Med & Rehabil, Jl Pasteur 38, Bandung 40161, Indonesia.
   [Rosdianto, Aziiz Mardanarian] Univ Padjadjaran, Fac Med, Dept Biomed Sci, Cell Commun Pillar, Sumedang KM 21, Jatinangor 45363, Indonesia.
   [Qiantori, Adziqa Ammara] Univ Padjadjaran, Fac Med, Sumedang Km 21, Jatinangor 45363, Indonesia.
C3 Universitas Padjadjaran; Clinical Laboratory Prodia; Universitas
   Padjadjaran; Universitas Padjadjaran; Dr Hasan Sadikin General Hospital;
   Universitas Padjadjaran; Universitas Padjadjaran
RP Meiliana, A (corresponding author), Univ Padjajaran, Fac Pharm, Dept Pharmacol & Clin Pharm, Sumedang Km 21, Jatinangor 45363, Indonesia.; Meiliana, A (corresponding author), Prodia Clin Lab, Jl Supratman 43, Bandung 40114, Indonesia.
EM anna.meiliana@unpad.ac.id
RI Defi, Irma/ADB-2780-2022; Meiliana, Anna/ABC-9368-2020
FU Layanan Direktorat Riset, Teknologi, dan Pengabdian Kepada Masyarakat
   [3824/UN6.3.1/PT.00/2024]
FX This work was supported by Layanan Direktorat Riset, Teknologi, dan
   Pengabdian Kepada Masyarakat [Grant No. 3824/UN6.3.1/PT.00/2024].
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NR 198
TC 1
Z9 1
U1 2
U2 4
PU PRODIA EDUCATION & RESEARCH INST
PI JAKARTA
PA PRODIA TOWER 8TH FLR, JL KRAMAT RAYA NO 150, JAKARTA, 00000, INDONESIA
SN 2355-9179
J9 INDONES BIOMED J
JI Indones. Biomed. J.
PD AUG
PY 2024
VL 16
IS 4
BP 292
EP 308
DI 10.18585/inabj.v16i4.3176
PG 17
WC Medicine, Research & Experimental
WE Emerging Sources Citation Index (ESCI)
SC Research & Experimental Medicine
GA F4P1M
UT WOS:001309645000001
OA gold
DA 2025-06-11
ER

PT J
AU Zeng, CF
   Chen, MK
AF Zeng, Chuanfei
   Chen, Mingkai
TI Progress in Nonalcoholic Fatty Liver Disease: SIRT Family Regulates
   Mitochondrial Biogenesis
SO BIOMOLECULES
LA English
DT Review
DE SIRT family; mitochondria; nonalcoholic fatty liver disease; research
   progress
ID FOXO TRANSCRIPTION FACTORS; DIET-INDUCED OBESITY; OXIDATIVE STRESS; ACID
   OXIDATION; THERAPEUTIC TARGET; ADIPOCYTE DIFFERENTIATION; CALORIE
   RESTRICTION; INSULIN-RESISTANCE; METABOLIC SYNDROME; DEACETYLASE SIRT3
AB Nonalcoholic fatty liver disease (NAFLD) is characterized by hepatic steatosis, insulin resistance, mitochondrial dysfunction, inflammation, and oxidative stress. As a group of NAD+-dependent III deacetylases, the sirtuin (SIRT1-7) family plays a very important role in regulating mitochondrial biogenesis and participates in the progress of NAFLD. SIRT family members are distributed in the nucleus, cytoplasm, and mitochondria; regulate hepatic fatty acid oxidation metabolism through different metabolic pathways and mechanisms; and participate in the regulation of mitochondrial energy metabolism. SIRT1 may improve NAFLD by regulating ROS, PGC-1 alpha, SREBP-1c, FoxO1/3, STAT3, and AMPK to restore mitochondrial function and reduce steatosis of the liver. Other SIRT family members also play a role in regulating mitochondrial biogenesis, fatty acid oxidative metabolism, inflammation, and insulin resistance. Therefore, this paper comprehensively introduces the role of SIRT family in regulating mitochondrial biogenesis in the liver in NAFLD, aiming to further explain the importance of SIRT family in regulating mitochondrial function in the occurrence and development of NAFLD, and to provide ideas for the research and development of targeted drugs. Relatively speaking, the role of some SIRT family members in NAFLD is still insufficiently clear, and further research is needed.
C1 [Zeng, Chuanfei; Chen, Mingkai] Wuhan Univ, Dept Gastroenterol, Renmin Hosp, 99 Zhang Zhidong Rd, Wuhan 430060, Peoples R China.
C3 Wuhan University
RP Chen, MK (corresponding author), Wuhan Univ, Dept Gastroenterol, Renmin Hosp, 99 Zhang Zhidong Rd, Wuhan 430060, Peoples R China.
EM chenmingkai@whu.edu.cn
OI Chen, Mingkai/0000-0001-6771-0523
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NR 175
TC 53
Z9 54
U1 4
U2 50
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2218-273X
J9 BIOMOLECULES
JI Biomolecules
PD AUG
PY 2022
VL 12
IS 8
AR 1079
DI 10.3390/biom12081079
PG 15
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 4C2XJ
UT WOS:000846322800001
PM 36008973
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Chauveau, P
   Koppe, L
   Combe, C
   Lasseur, C
   Trolonge, S
   Aparicio, M
AF Chauveau, Philippe
   Koppe, Laetitia
   Combe, Christian
   Lasseur, Catherine
   Trolonge, Stanislas
   Aparicio, Michel
TI Vegetarian diets and chronic kidney disease
SO NEPHROLOGY DIALYSIS TRANSPLANTATION
LA English
DT Review
DE kidney disease; nutrition; vegetarianism
ID ALL-CAUSE MORTALITY; LOW-PROTEIN-DIET; BLOOD-PRESSURE; OXIDATIVE STRESS;
   INSULIN-RESISTANCE; FIBER INTAKE; ADVENTIST HEALTH; GUT MICROBIOTA; ACID
   LOAD; INDOXYL SULFATE
AB While dietary restriction of protein intake has long been proposed as a possible kidney-protective treatment, the effects of changes in the quality of ingested proteins on the prevalence and risk of progression of chronic kidney disease (CKD) have been scarcely studied; these two aspects are reviewed in the present article. The prevalence of hypertension, type 2 diabetes and metabolic syndrome, which are the main causes of CKD in Western countries, is lower in vegetarian populations. Moreover, there is a negative relationship between several components of plant-based diets and numerous factors related to CKD progression such as uraemic toxins, inflammation, oxidative stress, metabolic acidosis, phosphate load and insulin resistance. In fact, results from different studies seem to confirm a kidney-protective effect of plant-based diets in the primary prevention of CKD and the secondary prevention of CKD progression. Various studies have determined the nutritional safety of plant-based diets in CKD patients, despite the combination of a more or less severe dietary protein restriction. As observed in the healthy population, this dietary pattern is associated with a reduced risk of all-cause mortality in CKD patients. We propose that plant-based diets should be included as part of the clinical recommendations for both the prevention and management of CKD.
C1 [Chauveau, Philippe; Combe, Christian; Lasseur, Catherine; Trolonge, Stanislas] Aurad Aquitaine, Serv Hemodialyse, Gradignan, France.
   [Chauveau, Philippe; Combe, Christian; Lasseur, Catherine; Aparicio, Michel] CHU Bordeaux, Hop Pellegrin, Serv Nephrol Transplantat Dialyse, Bordeaux, France.
   [Koppe, Laetitia] Ctr Hosp Lyon Sud, Hosp Civils Lyon, Dept Nephrol, Pierre Benite, France.
   [Koppe, Laetitia] Univ Claude Bernard Lyon 1, Univ Lyon, CarMeN Lab, INSERM U1060,INRA U1397,INSA Lyon, Villeurbanne, France.
   [Combe, Christian] Univ Bordeaux, Unite INSERM 1026, Bordeaux, France.
C3 CHU Bordeaux; Universite de Bordeaux; CHU Lyon; INRAE; Institut National
   de la Sante et de la Recherche Medicale (Inserm); Institut National des
   Sciences Appliquees de Lyon - INSA Lyon; Universite Claude Bernard Lyon
   1; Institut National de la Sante et de la Recherche Medicale (Inserm);
   Universite de Bordeaux
RP Chauveau, P (corresponding author), Aurad Aquitaine, Serv Hemodialyse, Gradignan, France.; Chauveau, P (corresponding author), CHU Bordeaux, Hop Pellegrin, Serv Nephrol Transplantat Dialyse, Bordeaux, France.
EM ph.chauveau@gmail.com
RI Laetitia, KOPPE/I-5978-2015; Pagnoux, Christian/C-4612-2015
OI Lab, Carmen/0000-0002-5935-3236; Chauveau, Philippe/0000-0002-7072-195X;
   Carmen, Team1/0000-0003-4234-1746
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NR 80
TC 53
Z9 56
U1 2
U2 52
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0931-0509
EI 1460-2385
J9 NEPHROL DIAL TRANSPL
JI Nephrol. Dial. Transplant.
PD FEB
PY 2019
VL 34
IS 2
BP 199
EP 207
DI 10.1093/ndt/gfy164
PG 10
WC Transplantation; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Transplantation; Urology & Nephrology
GA HM2TG
UT WOS:000459322000005
PM 29982610
OA Bronze
DA 2025-06-11
ER

PT J
AU Taniguchi, CM
   Aleman, JO
   Ueki, K
   Luo, J
   Asano, T
   Kaneto, H
   Stephanopoulos, G
   Cantley, LC
   Kahn, CR
AF Taniguchi, Cullen M.
   Aleman, Jose O.
   Ueki, Kohjiro
   Luo, Ji
   Asano, Tomoichiro
   Kaneto, Hideaki
   Stephanopoulos, Gregory
   Cantley, Lewis C.
   Kahn, C. Ronald
TI The p85α regulatory subunit of phosphoinositide 3-kinase potentiates
   c-Jun N-terminal kinase-mediated insulin resistance
SO MOLECULAR AND CELLULAR BIOLOGY
LA English
DT Article
ID ACTIVATED PROTEIN-KINASE; RHO-FAMILY GTPASES; PHOSPHATIDYLINOSITOL
   3-KINASE; MICE LACKING; SIGNALING PATHWAYS; P85; GLUCOSE; OBESITY;
   ALPHA; GENE
AB Insulin resistance is a defining feature of type 2 diabetes and the metabolic syndrome. While the molecular mechanisms of insulin resistance are multiple, recent evidence suggests that attenuation of insulin signaling by c-Jun N-terminal kinase (JNK) may be a central part of the pathobiology of insulin resistance. Here we demonstrate that the p85 alpha regulatory subunit of phosphoinositide 3-kinase (PI3K), a key mediator of insulin's metabolic actions, is also required for the activation of JNK in states of insulin resistance, including high-fat diet-induced obesity and JNK1 overexpression. The requirement of the p85a regulatory subunit for JNK occurs independently of its role as a component of the PI3K heterodimer and occurs only in response to specific stimuli, namely, insulin and tunicamycin, a chemical that induces endoplasmic reticulum stress. We further show that insulin and p85 activate JNK by via cdc42 and MKK4. The activation of this cdc42/JNK pathway requires both an intact N terminus and functional SH2 domains within the C terminus of the p85 alpha regulatory subunit. Thus, p85 alpha plays a dual role in regulating insulin sensitivity and may mediate cross talk between the PI3K and stress kinase pathways.
C1 Harvard Univ, Joslin Diabet Ctr, Sch Med, Boston, MA 02215 USA.
   MIT, Dept Chem Engn, Cambridge, MA 02139 USA.
   Univ Tokyo, Grad Sch Med, Dept Metab Dis, Tokyo, Japan.
   Harvard Univ, Sch Med, Dept Syst Biol, Boston, MA 02215 USA.
   Beth Israel Deaconess Med Ctr, Div Signal Transduct, Boston, MA 02115 USA.
   Univ Tokyo, Fac Med, Dept Internal Med 3, Tokyo 113, Japan.
   Osaka Univ, Grad Sch Med, Dept Internal Med & Therapeut A8, Suita, Osaka, Japan.
C3 Harvard University; Harvard University Medical Affiliates; Joslin
   Diabetes Center, Inc.; Harvard Medical School; Massachusetts Institute
   of Technology (MIT); University of Tokyo; Harvard University; Harvard
   Medical School; Harvard University; Harvard University Medical
   Affiliates; Beth Israel Deaconess Medical Center; University of Tokyo;
   The University of Osaka
RP Kahn, CR (corresponding author), Harvard Univ, Joslin Diabet Ctr, Sch Med, 1 Joslin Pl, Boston, MA 02215 USA.
EM c.ronald.kahn@joslin.harvard.edu
RI Ueki, Kohjiro/MGU-5108-2025; Kahn, Ronald/AAY-2435-2021; Luo,
   Ji/G-5693-2017; Cantley, Lewis/D-1800-2014
OI Aleman, Jose/0000-0003-3753-6717; Cantley, Lewis/0000-0002-1298-7653;
   Taniguchi, Cullen/0000-0002-8052-3316
FU NCI NIH HHS [CA089021, P01 CA089021] Funding Source: Medline; NIDDK NIH
   HHS [DK33201, DK55545, DK34834, R01 DK055545, R01 DK033201] Funding
   Source: Medline; NIGMS NIH HHS [GM41890, R01 GM041890, R37 GM041890]
   Funding Source: Medline
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NR 55
TC 66
Z9 76
U1 0
U2 5
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0270-7306
J9 MOL CELL BIOL
JI Mol. Cell. Biol.
PD APR
PY 2007
VL 27
IS 8
BP 2830
EP 2840
DI 10.1128/MCB.00079-07
PG 11
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA 155DP
UT WOS:000245558300005
PM 17283057
OA Green Published
DA 2025-06-11
ER

PT J
AU Di Carli, MF
   Hachamovitch, R
AF Di Carli, MF
   Hachamovitch, R
TI Should we screen for occult coronary artery disease among asymptomatic
   patients with diabetes?
SO JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
LA English
DT Article
ID EMISSION COMPUTED-TOMOGRAPHY; INCREMENTAL PROGNOSTIC VALUE;
   SILENT-MYOCARDIAL-ISCHEMIA; METABOLIC SYNDROME; HEART-DISEASE; RISK;
   ATHEROSCLEROSIS; IMPACT; MORTALITY; SYMPTOMS
AB Diabetes mellitus predisposes people to premature atherosclerotic coronary artery disease (CAD). The risk of a myocardial infarction in diabetics without overt evidence of obstructive CAD matches that of patients without diabetes who have had a previous myocardial infarction. The available data suggest that occult CAD is a common finding among asymptomatic diabetics, ranging from 20% to >50%. The diagnostic accuracy of myocardial perfusion single-photon emission computed tomography (SPECT) in diabetics appears to be comparable to that observed in nondiabetic individuals. As shown in other patient groups, the ischemic burden assessed by stress SPECT in subjects with diabetes is also linked to their increased risk of adverse cardiovascular events. Among patients with normal stress SPECT, however, those with diabetes are at significantly greater risk than non-diabetics. Testing diabetics with an abnormal resting electrocardiogram or with evidence of peripheral or carotid occlusive arterial disease appears to result in an excellent yield of abnormal SPECT findings, as does testing in the setting of dyspnea. However, recent evidence suggests that achieving an adequate yield in asymptomatic diabetics without overt evidence of CAD is a greater challenge. Further investigation of sequential testing strategies is needed in order to identify an efficient means for screening asymptomatic patients with diabetes. (C) 2005 by the American College of Cardiology Foundation.
C1 Brigham & Womens Hosp, Div Nucl Med, Dept Radiol, Boston, MA 02115 USA.
   Harvard Univ, Sch Med, Boston, MA USA.
   Univ So Calif, Dept Med, Div Cardiol, Los Angeles, CA 90089 USA.
C3 Harvard University; Harvard University Medical Affiliates; Brigham &
   Women's Hospital; Harvard University; Harvard Medical School; University
   of Southern California
RP Brigham & Womens Hosp, Div Nucl Med, Dept Radiol, 75 Francis St, Boston, MA 02115 USA.
EM mdicarli@partners.org
CR *AM DIAB ASS, 2004, NATL DIAB FACT SHEET
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NR 37
TC 55
Z9 57
U1 0
U2 3
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0735-1097
EI 1558-3597
J9 J AM COLL CARDIOL
JI J. Am. Coll. Cardiol.
PD JAN 4
PY 2005
VL 45
IS 1
BP 50
EP 53
DI 10.1016/j.jacc.2004.09.055
PG 4
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 883LF
UT WOS:000226012600009
PM 15629372
OA Bronze
DA 2025-06-11
ER

PT J
AU Sinha, S
   Haque, M
AF Sinha, Susmita
   Haque, Mainul
TI Obesity, Diabetes Mellitus, and Vascular Impediment as Consequences of
   Excess Processed Food Consumption
SO CUREUS JOURNAL OF MEDICAL SCIENCE
LA English
DT Article
DE blood vessels; phosphate; preservatives; food additives; freshly; oven
   to table; precooked food; prepackaged food; unhealthy food; junk food
ID CHRONIC KIDNEY-DISEASE; MITOCHONDRIAL OXIDATIVE STRESS;
   NECROSIS-FACTOR-ALPHA; SMOOTH-MUSCLE-CELLS; BODY-MASS INDEX;
   METABOLIC-SYNDROME; ADIPOSE-TISSUE; MONOSODIUM GLUTAMATE; DIETARY
   PHOSPHORUS; PHOSPHATE TOXICITY
AB Regular intake of ready-to-eat meals is related to obesity and several noninfectious illnesses, such as cardiovascular diseases, hypertension, diabetes mellitus (DM), and tumors. Processed foods contain high calories and are often enhanced with excess refined sugar, saturated and trans fat, Na+ and phosphatecontaining taste enhancers, and preservatives. Studies showed that monosodium glutamate (MSG) induces raised echelons of oxidative stress, and excessive hepatic lipogenesis is concomitant to obesity and type 2 diabetes mellitus (T2DM). Likewise, more than standard salt intake adversely affects the cardiovascular system, renal system, and central nervous system (CNS), especially the brain. Globally, excessive utilization of phosphate-containing preservatives and additives contributes unswervingly to excessive phosphate intake through food. In addition, communities and even health experts, including medical doctors, are not well-informed about the adverse effects of phosphate preservatives on human health. Dietary phosphate excess often leads to phosphate toxicity, ultimately potentiating kidney disease development. The mechanisms involved in phosphate-related adverse effects are not explainable. Study reports suggested that high blood level of phosphate causes vascular ossification through the deposition of Ca2+ and substantially alters fibroblast growth factor-23 (FGF23) and calcitriol.
C1 [Sinha, Susmita] Khulna City Med Coll & Hosp, Physiol, Khulna, Bangladesh.
   [Haque, Mainul] Natl Def Univ Malaysia, Pharmacol & Therapeut, Kuala Lumpur, Malaysia.
C3 Universiti Pertahanan Nasional Malaysia
RP Haque, M (corresponding author), Natl Def Univ Malaysia, Pharmacol & Therapeut, Kuala Lumpur, Malaysia.
EM runurono@gmail.com
RI Sinha, Susmita/HGC-1750-2022; Haque, Mainul/ABG-2866-2020
OI Sinha, Susmita/0000-0002-3591-1109
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NR 244
TC 4
Z9 4
U1 0
U2 20
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
EI 2168-8184
J9 CUREUS J MED SCIENCE
JI Cureus J Med Sci
PD SEP 4
PY 2022
VL 14
IS 9
AR e28762
DI 10.7759/cureus.28762
PG 24
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA 5A7UW
UT WOS:000863089300008
PM 36105908
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Elshareif, N
   Gavini, CK
   Mansuy-Aubert, V
AF Elshareif, Nadia
   Gavini, Chaitanya K.
   Mansuy-Aubert, Virginie
TI LXR agonist modifies neuronal lipid homeostasis and decreases PGD2 in
   the dorsal root ganglia in western diet-fed mice
SO SCIENTIFIC REPORTS
LA English
DT Article
ID ENDOPLASMIC-RETICULUM STRESS; LIVER X RECEPTORS; GENE-EXPRESSION;
   METABOLIC SYNDROME; OXIDATIVE STRESS; MURINE MODEL; FATTY-ACIDS;
   NEUROPATHY; DYSFUNCTION; PAIN
AB The prevalence of peripheral neuropathy is high in diabetic and overweight populations. Chronic neuropathic pain, a symptom of peripheral neuropathy, is a major disabling symptom that leads to a poor quality of life. Glucose management for diabetic and prediabetic individuals often fail to reduce or improve pain symptoms, therefore, exploring other mechanisms is necessary to identify effective treatments. A large body of evidence suggest that lipid signaling may be a viable target for management of peripheral neuropathy in obese individuals. The nuclear transcription factors, Liver X Receptors (LXR), are known regulators of lipid homeostasis, phospholipid remodeling, and inflammation. Notably, the activation of LXR using the synthetic agonist GW3965, delayed western diet (WD)-induced allodynia in rodents. To further understand the neurobiology underlying the effect of LXR, we used translating ribosome affinity purification and evaluated translatomic changes in the sensory neurons of WD-fed mice treated with the LXR agonist GW3965. We also observed that GW3965 decreased prostaglandin levels and decreased free fatty acid content, while increasing lysophosphatidylcholine, phosphatidylcholine, and cholesterol ester species in the sensory neurons of the dorsal root ganglia (DRG). These data suggest novel downstream interplaying mechanisms that modifies DRG neuronal lipid following GW3965 treatment.
C1 [Elshareif, Nadia; Gavini, Chaitanya K.; Mansuy-Aubert, Virginie] Loyola Univ, Stritch Sch Med, Cell & Mol Physiol, Maywood, IL 60153 USA.
C3 Loyola University Chicago
RP Mansuy-Aubert, V (corresponding author), Loyola Univ, Stritch Sch Med, Cell & Mol Physiol, Maywood, IL 60153 USA.
EM vmansuyaubert@luc.edu
OI Elshareif, Nadia/0000-0002-3819-3958; Mansuy-Aubert,
   Virginie/0000-0002-9976-446X
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NR 57
TC 4
Z9 4
U1 0
U2 3
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD JUN 24
PY 2022
VL 12
IS 1
AR 10754
DI 10.1038/s41598-022-14604-0
PG 10
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 2J3BY
UT WOS:000815538100010
PM 35750708
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Vamanu, E
   Dinu, LD
   Pelinescu, DR
   Gatea, F
AF Vamanu, Emanuel
   Dinu, Laura Dorina
   Pelinescu, Diana Roxana
   Gatea, Florentina
TI Therapeutic Properties of Edible Mushrooms and Herbal Teas in Gut
   Microbiota Modulation
SO MICROORGANISMS
LA English
DT Review
DE pattern; miRNAs; antioxidant; SCFAs; polyphenols
ID POTENTIAL HEALTH-BENEFITS; DIETARY FIBER FRACTIONS; IN-VITRO
   FERMENTATION; EDODES BERK. PEGLER; ANTITUMOR-ACTIVITY; NATURAL-PRODUCTS;
   INTESTINAL MICROBIOTA; METABOLIC SYNDROME; GREEN TEA; MICRORNAS
AB Edible mushrooms are functional foods and valuable but less exploited sources of biologically active compounds. Herbal teas are a range of products widely used due to the therapeutic properties that have been demonstrated by traditional medicine and a supplement in conventional therapies. Their interaction with the human microbiota is an aspect that must be researched, the therapeutic properties depending on the interaction with the microbiota and the consequent fermentative activity. Modulation processes result from the activity of, for example, phenolic acids, which are a major component and which have already demonstrated activity in combating oxidative stress. The aim of this mini-review is to highlight the essential aspects of modulating the microbiota using edible mushrooms and herbal teas. Although the phenolic pattern is different for edible mushrooms and herbal teas, certain non-phenolic compounds (polysaccharides and/or caffeine) are important in alleviating chronic diseases. These specific functional compounds have modulatory properties against oxidative stress, demonstrating health-beneficial effects in vitro and/or In vivo. Moreover, recent advances in improving human health via gut microbiota are presented. Plant-derived miRNAs from mushrooms and herbal teas were highlighted as a potential strategy for new therapeutic effects.
C1 [Vamanu, Emanuel; Dinu, Laura Dorina] Univ Agron Sci & Vet Med, Fac Biotechnol, 59 Marasti Blvd,1 Dist, Bucharest 011464, Romania.
   [Pelinescu, Diana Roxana] Univ Bucharest, Dept Genet, 36-46 Bd M Kogalniceanu,5th Dist, Bucharest 050107, Romania.
   [Gatea, Florentina] Natl Inst Biol Sci, Ctr Bioanal, 296 Spl Independentei, Bucharest 060031, Romania.
C3 University of Agronomic Science & Veterinary Medicine - Bucharest;
   University of Bucharest; National Institute of Gerontology & Geriatrics
   "Ana Aslan"; National Research Institute for Biological Sciences
RP Vamanu, E (corresponding author), Univ Agron Sci & Vet Med, Fac Biotechnol, 59 Marasti Blvd,1 Dist, Bucharest 011464, Romania.
EM email@emanuelvamanu.ro; laura.dinu@biotehnologii.usamv.ro;
   diana.pelinescu@bio.unibuc.ro; florentina.gatea@incdsb.ro
RI Dinu, Laura-Dorina/C-5066-2011; Florentina, Gatea/F-9078-2011; Vamanu,
   Emanuel/E-9084-2012; Pelinescu, Diana/Y-3869-2019
OI Florentina, Gatea/0000-0002-6617-9811; Vamanu,
   Emanuel/0000-0002-3376-2058; Dinu, Laura-Dorina/0000-0001-7946-5158;
   Pelinescu, Diana/0000-0003-0685-4659
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NR 120
TC 15
Z9 15
U1 0
U2 34
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-2607
J9 MICROORGANISMS
JI Microorganisms
PD JUN
PY 2021
VL 9
IS 6
AR 1262
DI 10.3390/microorganisms9061262
PG 18
WC Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Microbiology
GA SZ3VG
UT WOS:000666496400001
PM 34200833
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Calzada, M
   López, N
   Noguera, JA
   Mendiola, J
   Torres, AM
AF Calzada, M.
   Lopez, N.
   Noguera, J. A.
   Mendiola, J.
   Torres, A. M.
TI Elevation of isoprostanes in polycystic ovary syndrome and its
   relationship with cardiovascular risk factors
SO JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
LA English
DT Article
DE Polycystic ovary syndrome; Insulin resistance; Oxidative stress;
   8-Isoprostanes; Infertility
ID C-REACTIVE PROTEIN; INCREASED OXIDATIVE STRESS; INSULIN-RESISTANCE;
   METABOLIC SYNDROME; ANDROGEN EXCESS; WOMEN; HOMOCYSTEINE;
   F-2-ISOPROSTANES; 8-ISOPROSTANE; PREVALENCE
AB PurposeTo evaluate the plasma level of 8-isoprostanes in women with polycystic ovary syndrome. To also investigate whether there is a relationship between 8-isoprostanes and several cardiovascular risk factors.MethodsA total of 125 women with polycystic ovary syndrome and 169 healthy women were enrolled in this case-control study. 8-Isoprostanes and different parameters were measured in all subjects. Patients were evaluated for the presence of polycystic ovary syndrome according to the Rotterdam Consensus Conference criteria.Results8-Isoprostanes levels were significantly higher in patients with polycystic ovary syndrome (138.4104.1pg/mL) compared with control group (68.6 +/- 34.3pg/mL) (p<0.001). The mean of triglycerides, lipid accumulation product, C-reactive protein, homocysteine, insulin, and homeostatic model assessment for insulin resistance were significantly higher in polycystic ovary syndrome patients with high 8-isoprostanes than those with normal 8-isoprostanes (p<0.05). The Pearson correlation analyses showed that 8-isoprostanes levels in polycystic ovary syndrome group had a positive correlation with waist circumference, triglycerides, low-density lipoprotein cholesterol, apolipoprotein B, homocysteine, insulin, homeostatic model assessment for insulin resistance.Conclusions Patients with polycystic ovary syndrome have higher 8-isoprostanes levels and it is associated with several cardiovascular risk factors.
C1 [Calzada, M.; Lopez, N.; Noguera, J. A.] Hosp Univ Virgen Arrixaca, Clin Anal Serv, Ctra Madrid Cartagena S-N, Murcia 30120, Spain.
   [Mendiola, J.; Torres, A. M.] Univ Murcia, Div Prevent Med & Publ Hlth, Dept Hlth & Social Sci, Murcia, Spain.
C3 Hospital Clinico Universitario Virgen de la Arrixaca; University of
   Murcia
RP Calzada, M (corresponding author), Hosp Univ Virgen Arrixaca, Clin Anal Serv, Ctra Madrid Cartagena S-N, Murcia 30120, Spain.
EM mireyacalzada9@gmail.com
RI Noguera-Velasco, José/AAB-2494-2019; López, Natividad/ABH-1323-2020;
   Mendiola, Jaime/G-7829-2018; Torres-Cantero, Alberto/F-1087-2017
OI Lopez, Natividad/0000-0003-0423-4616; Noguera Velasco, Jose
   Antonio/0000-0001-6786-4864; Mendiola, Jaime/0000-0002-0657-9346;
   Torres-Cantero, Alberto M./0000-0001-5402-1016
FU Institute of Health Carlos III (ISCIII) [PI13/01237]
FX This work was supported by a grant from the Institute of Health Carlos
   III (ISCIII) (no PI13/01237).
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NR 57
TC 3
Z9 3
U1 0
U2 5
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0391-4097
EI 1720-8386
J9 J ENDOCRINOL INVEST
JI J. Endocrinol. Invest.
PD JAN
PY 2019
VL 42
IS 1
BP 75
EP 83
DI 10.1007/s40618-018-0888-y
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA HF5KE
UT WOS:000454270400009
PM 29687417
DA 2025-06-11
ER

EF﻿FN Clarivate Analytics Web of Science
VR 1.0
PT J
AU Korkmaz, ÖA
   Sadi, G
   Kocabas, A
   Yildirim, OG
   Sumlu, E
   Koca, HB
   Nalbantoglu, B
   Pektas, MB
   Akar, F
AF Korkmaz, Omer Adil
   Sadi, Gokhan
   Kocabas, Aytac
   Yildirim, Onur Gokhan
   Sumlu, Esra
   Koca, Halit Bugra
   Nalbantoglu, Barbaros
   Pektas, Mehmet Bilgehan
   Akar, Fatma
TI Lactobacillus helveticus and Lactobacillus plantarum
   modulate renal antioxidant status in a rat model of fructose-induced
   metabolic syndrome
SO ARCHIVES OF BIOLOGICAL SCIENCES
LA English
DT Article
DE dietary fructose; renal antioxidant status; antioxidant enzymes;
   Lactobacillus helveticus; Lactobacillus plantarum
ID OXIDATIVE STRESS; INSULIN-RESISTANCE; PROBIOTIC STRAINS;
   LIPID-METABOLISM; CURVATUS HY7601; L-CARNITINE; URIC-ACID; INFLAMMATION;
   DYSFUNCTION; KIDNEY
AB High dietary fructose intake causes a metabolic disorder and augments the risk of chronic kidney disease most likely due to oxidative stress. Probiotics could have antioxidant, antiinflammatory and immunoregulatory properties. The present study examined the influence of Lactobacillus helveticus and Lactobacillus plantarum supplementation on dietary fructose-induced metabolic changes and renal antioxidant/oxidant status of rats. Male Wistar rats were divided into four groups as follows: control; fructose; fructose plus L. helveticus; fructose plus L. plantarum. Fructose was given to the rats as a 20% solution in drinking water for 15 weeks. The probiotic supplementation was applied by gastric gavage once a day for six weeks. Several metabolic parameters in the plasma, gene and protein expressions of the main antioxidant enzymes in renal tissues of rats were measured. Dietary fructose-induced elevations in plasma insulin, triglyceride, VLDL, creatinine as well as renal urea levels were alleviated after treatment with L. helveticus and L. plantarum. Moreover, L. helveticus and L. plantarum supplementation recovered the changes in renal protein expression level of SOD1, SOD2 and CAT. In conclusion, supplementation with L. helveticus and L. plantarum has an improving effect on specific metabolic parameters and renal antioxidative enzymes in a fructose-induced metabolic disorder.
C1 [Korkmaz, Omer Adil; Nalbantoglu, Barbaros] Yildiz Tech Univ, Fac Sci, Dept Chem, TR-34220 Istanbul, Turkey.
   [Sadi, Gokhan; Kocabas, Aytac] Karamanoglu Mehmetbey Univ, KO Sci Fac, Dept Biol, TR-70100 Karaman, Turkey.
   [Yildirim, Onur Gokhan] Artvin Coruh Univ, Hlth Serv Vocat Sch, Dept Pharm Serv, TR-08100 Artvin, Turkey.
   [Sumlu, Esra; Akar, Fatma] Gazi Univ, Fac Pharm, Dept Pharmacol, TR-06330 Ankara, Turkey.
   [Koca, Halit Bugra] Afyonkarahisar Hlth Sci Univ, Fac Med, Dept Med Biochem, TR-03200 Afyon, Turkey.
   [Pektas, Mehmet Bilgehan] Afyonkarahisar Hlth Sci Univ, Fac Med, Dept Med Pharmacol, TR-03200 Afyon, Turkey.
C3 Yildiz Technical University; Karamanoglu Mehmetbey University; Artvin
   Coruh University; Gazi University; Afyonkarahisar Health Sciences
   University; Afyonkarahisar Health Sciences University
RP Pektas, MB (corresponding author), Afyonkarahisar Hlth Sci Univ, Fac Med, Dept Med Pharmacol, TR-03200 Afyon, Turkey.
EM mbpektas@hotmail.com
RI KORKMAZ, Ömer/ISA-3636-2023; YILDIRIM, Onur Gokhan/AAA-9156-2022;
   Kocabas, Aytac/F-5933-2013; PEKTAŞ, MEHMET/V-7886-2017; SUMLU,
   Esra/T-7660-2019; Nalbantoğlu, Barbaros/AAZ-8908-2020; Sadi,
   Gökhan/AAK-5468-2021; Akar, Fatma/D-1650-2018
OI Sumlu, Esra/0000-0002-5004-5958; Akar, Fatma/0000-0002-5432-0304;
   YILDIRIM, ONUR GOKHAN/0000-0003-0090-7369; Pektas, Bilgehan
   Mehmet/0000-0003-0055-7688; Sadi, Gokhan/0000-0002-6422-1203
FU Karamanoglu Mehmetbey University Research Fund [29-M-15]; Yildiz
   Technical University Research Fund [FDK-2018-3392]
FX This study was supported by grants from the Karamanoglu Mehmetbey
   University Research Fund (29-M-15) and Yildiz Technical University
   Research Fund (FDK-2018-3392).
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NR 54
TC 11
Z9 11
U1 1
U2 34
PU INST BIOLOSKA ISTRAZIVANJA SINISA STANKOVIC
PI BEOGRAD
PA 29 NOVEMBRA 142, BEOGRAD, 11060, SERBIA
SN 0354-4664
EI 1821-4339
J9 ARCH BIOL SCI
JI Arch. Biol. Sci.
PY 2019
VL 71
IS 2
BP 265
EP 273
DI 10.2298/ABS190123008K
PG 9
WC Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics
GA IC6GM
UT WOS:000471069700008
OA gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Lang, E
   Lang, F
AF Lang, Elisabeth
   Lang, Florian
TI Triggers, Inhibitors, Mechanisms, and Significance of Eryptosis: The
   Suicidal Erythrocyte Death
SO BIOMED RESEARCH INTERNATIONAL
LA English
DT Review
ID RED-BLOOD-CELLS; CHRONIC KIDNEY-DISEASE; INDUCED PHOSPHATIDYLSERINE
   TRANSLOCATION; MEMBRANE PHOSPHOLIPID ORGANIZATION; NITRIC-OXIDE;
   PLASMODIUM-FALCIPARUM; OXIDATIVE STRESS; CATION CHANNELS;
   S-NITROSYLATION; IN-VITRO
AB Suicidal erythrocyte death or eryptosis is characterized by erythrocyte shrinkage, cell membrane blebbing, and cell membrane scrambling with phosphatidylserine translocation to the erythrocyte surface. Triggers of eryptosis include Ca2+ entry, ceramide formation, stimulation of caspases, calpain activation, energy depletion, oxidative stress, and dysregulation of several kinases. Eryptosis is triggered by a wide variety of xenobiotics. It is inhibited by several xenobiotics and endogenous molecules including NO and erythropoietin. The susceptibility of erythrocytes to eryptosis increases with erythrocyte age. Phosphatidylserine exposing erythrocytes adhere to the vascular wall by binding to endothelial CXC-Motiv-Chemokin-16/Scavenger-receptor for phosphatidylserine and oxidized low density lipoprotein (CXCL16). Phosphatidylserine exposing erythrocytes are further engulfed by phagocytosing cells and are thus rapidly cleared from circulating blood. Eryptosis eliminates infected or defective erythrocytes thus counteracting parasitemia in malaria and preventing detrimental hemolysis of defective cells. Excessive eryptosis, however, may lead to anemia and may interfere with microcirculation. Enhanced eryptosis contributes to the pathophysiology of several clinical disorders including metabolic syndrome and diabetes, malignancy, cardiac and renal insufficiency, hemolytic uremic syndrome, sepsis, mycoplasma infection, malaria, iron deficiency, sickle cell anemia, thalassemia, glucose 6-phosphate dehydrogenase deficiency, and Wilson's disease. Facilitating or inhibiting eryptosis may be a therapeutic option in those disorders.
C1 [Lang, Elisabeth; Lang, Florian] Univ Tubingen, Dept Physiol, D-72076 Tubingen, Germany.
C3 Eberhard Karls University of Tubingen
RP Lang, F (corresponding author), Univ Tubingen, Dept Physiol, Gmelinstr 5, D-72076 Tubingen, Germany.
EM florian.lang@uni-tuebingen.de
FU Deutsche Forschungsgemeinschaft
FX The authors acknowledge the meticulous preparation of the paper by Tanja
   Loch. Research in the authors' laboratory was supported by the Deutsche
   Forschungsgemeinschaft.
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NR 305
TC 119
Z9 128
U1 0
U2 16
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2314-6133
EI 2314-6141
J9 BIOMED RES INT
JI Biomed Res. Int.
PY 2015
VL 2015
AR 513518
DI 10.1155/2015/513518
PG 16
WC Biotechnology & Applied Microbiology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Research & Experimental Medicine
GA CD8VL
UT WOS:000351374400001
PM 25821808
OA Green Published, Green Submitted, hybrid
DA 2025-06-11
ER

PT J
AU Sismanopoulos, N
   Delivanis, DA
   Mavrommati, D
   Hatziagelaki, E
   Conti, P
   Theoharides, TC
AF Sismanopoulos, N.
   Delivanis, D. -A.
   Mavrommati, D.
   Hatziagelaki, E.
   Conti, P.
   Theoharides, T. C.
TI Do mast cells link obesity and asthma?
SO ALLERGY
LA English
DT Review
DE adipocytokines; asthma; cytokines; inflammation; obesity; treatment
ID CORTICOTROPIN-RELEASING HORMONE; AIRWAY SMOOTH-MUSCLE; ALLERGIC-ASTHMA;
   ADIPOSE-TISSUE; BODY-MASS; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   IMMUNOGLOBULIN-E; VASCULAR-PERMEABILITY; OXIDATIVE STRESS
AB Asthma is a chronic inflammatory disease of the lungs. Both the number of cases and severity of asthma have been increasing without a clear explanation. Recent evidence suggests that obesity, which has also been increasing alarmingly, may worsen or precipitate asthma, but there is little evidence of how obesity may contribute to lung inflammation. We propose that mast cells are involved in both asthma and obesity by being the target and source of adipocytokines, alarmins such as interleukin-9 (IL-9) and interleukin-33 (IL-33), and stress molecules including corticotropin-releasing hormone (CRH) and neurotensin (NT), secreted in response to the metabolic burden. In particular, CRH and NT have synergistic effects on mast cell secretion of vascular endothelial growth factor (VEGF). IL-33 augments VEGF release induced by substance P (SP) and tumor necrosis factor (TNF) release induced by NT. Both IL-9 and IL-33 also promote lung mast cell infiltration and augment allergic inflammation. These molecules are also expressed in human mast cells leading to autocrine effects. Obese patients are also less sensitive to glucocorticoids and bronchodilators. Development of effective mast cell inhibitors may be a novel approach for the management of both asthma and obesity. Certain flavonoid combinations may be a promising new treatment approach.
C1 [Sismanopoulos, N.; Delivanis, D. -A.; Mavrommati, D.; Theoharides, T. C.] Tufts Univ, Sch Med, Dept Mol Physiol & Pharmacol, Lab Mol Immunopharmacol & Drug Discovery, Boston, MA 02111 USA.
   [Hatziagelaki, E.] Univ Athens, Sch Med, Dept Internal Med 2, Attikon Gen Hosp, GR-11527 Athens, Greece.
   [Conti, P.] Univ G dAnnunzio, Dept Oncol & Expt Med, Chieti, Italy.
   [Theoharides, T. C.] Tufts Univ, Sch Med, Dept Biochem, Boston, MA 02111 USA.
   [Theoharides, T. C.] Tufts Univ, Sch Med, Dept Internal Med, Boston, MA 02111 USA.
   [Theoharides, T. C.] Tufts Med Ctr, Boston, MA USA.
C3 Tufts University; National & Kapodistrian University of Athens; Athens
   Medical School; University Hospital Attikon; G d'Annunzio University of
   Chieti-Pescara; Tufts University; Tufts University; Tufts Medical Center
RP Theoharides, TC (corresponding author), Tufts Univ, Sch Med, Dept Mol Physiol & Pharmacol, Lab Mol Immunopharmacol & Drug Discovery, 136 Harrison Ave,Suite J304, Boston, MA 02111 USA.
EM theoharis.theoharides@tufts.edu
RI Theoharides, Theoharis/E-5596-2010
FU US National Institutes of Health (NIH) [AR 47652, NS 66205, NS 71361]
FX Aspects of our work discussed here were supported in part by US National
   Institutes of Health (NIH) grants: AR 47652; NS 66205; and NS 71361 to
   TCT. Thanks are due to Smaro Panagiotidou for help with the word
   processing and Alexandra Miniati for help with the light micrograph.
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NR 123
TC 46
Z9 51
U1 1
U2 30
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0105-4538
EI 1398-9995
J9 ALLERGY
JI Allergy
PD JAN
PY 2013
VL 68
IS 1
BP 8
EP 15
DI 10.1111/all.12043
PG 8
WC Allergy; Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Allergy; Immunology
GA 049HX
UT WOS:000311974500002
PM 23066905
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Garbarino, J
   Padamsee, M
   Wilcox, L
   Oelkers, PM
   D'Ambrosio, D
   Ruggles, KV
   Ramsey, N
   Jabado, O
   Turkish, A
   Sturley, SL
AF Garbarino, Jeanne
   Padamsee, Mahajabeen
   Wilcox, Lisa
   Oelkers, Peter M.
   D'Ambrosio, Diana
   Ruggles, Kelly V.
   Ramsey, Nicole
   Jabado, Omar
   Turkish, Aaron
   Sturley, Stephen L.
TI Sterol and Diacylglycerol Acyltransferase Deficiency Triggers Fatty
   Acid-mediated Cell Death
SO JOURNAL OF BIOLOGICAL CHEMISTRY
LA English
DT Article
ID YEAST SACCHAROMYCES-CEREVISIAE; INDUCED INSULIN-RESISTANCE; GRAPHICAL
   USER-INTERFACE; GENE-EXPRESSION DATA; LIPID PARTICLES;
   TRIGLYCERIDE-METABOLISM; ENDOPLASMIC-RETICULUM; INDUCED APOPTOSIS;
   MICROARRAY DATA; ACYL-COENZYME
AB Deletion of the acyltransferases responsible for triglyceride and steryl ester synthesis in Saccharomyces cerevisiae serves as a genetic model of diseases where lipid overload is a component. The yeast mutants lack detectable neutral lipids and cytoplasmic lipid droplets and are strikingly sensitive to unsaturated fatty acids. Expression of human diacylglycerol acyltransferase 2 in the yeast mutants was sufficient to reverse these phenotypes. Similar to mammalian cells, fatty acid-mediated death in yeast is apoptotic and presaged by transcriptional induction of stress-response pathways, elevated oxidative stress, and activation of the unfolded protein response. To identify pathways that protect cells from lipid excess, we performed genetic interaction and transcriptional profiling screens with the yeast acyltransferase mutants. We thus identified diacylglycerol kinase-mediated phosphatidic acid biosynthesis and production of phosphatidylcholine via methylation of phosphatidylethanolamine as modifiers of lipotoxicity. Accordingly, the combined ablation of phospholipid and triglyceride biosynthesis increased sensitivity to saturated fatty acids. Similarly, normal sphingolipid biosynthesis and vesicular transport were required for optimal growth upon denudation of triglyceride biosynthesis and also mediated resistance to exogenous fatty acids. In metazoans, many of these processes are implicated in insulin secretion thus linking lipotoxicity with early aspects of pancreatic beta-cell dysfunction, diabetes, and the metabolic syndrome.
C1 [D'Ambrosio, Diana; Turkish, Aaron; Sturley, Stephen L.] Columbia Univ, Dept Pediat, Med Ctr, New York, NY 10032 USA.
   [Jabado, Omar] Columbia Univ, Dept Epidemiol, Med Ctr, New York, NY 10032 USA.
   [Ruggles, Kelly V.; Ramsey, Nicole; Sturley, Stephen L.] Columbia Univ, Inst Human Nutr, Med Ctr, New York, NY 10032 USA.
C3 Columbia University; Columbia University; Columbia University
RP Sturley, SL (corresponding author), Columbia Univ, Dept Pediat, Med Ctr, 630 W 168th St, New York, NY 10032 USA.
EM sls37@columbia.edu
RI Vasaikar, Suhas/AAJ-5885-2020
OI Ruggles, Kelly/0000-0002-0152-0863; Wilcox, Lisa/0009-0001-2642-4827;
   Padamsee, Mahajabeen/0000-0002-0741-3014
FU National Institutes of Health [DK54320, T32 HL007343, K12HD043389];
   NIDDK [2P30-DK63608-07]; American Diabetes Association; American Heart
   Association; Heart and Stroke Foundation of Canada; American Liver
   Foundation; Children's Digestive Health and Nutrition Foundation
FX This work was supported, in whole or in part, by National Institutes of
   Health Grant DK54320 (to S. L. S.) and Grant 2P30-DK63608-07 from NIDDK
   (pilot award from Diabetes and Endocrinology Research Center to Columbia
   University). This work was also supported by the American Diabetes
   Association and the American Heart Association.Supported by the Heart
   and Stroke Foundation of Canada.Supported in part by National Institutes
   of Health Grant T32 HL007343 (fellowship in arteriosclerosis
   research).Supported in part by National Institutes of Health Child
   Health Research Career Development Award K12HD043389, the American Liver
   Foundation, American Association for the Study of Liver Diseases Sheila
   Sherlock Award, and the Young Investigator Development Award of the
   Children's Digestive Health and Nutrition Foundation.
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NR 64
TC 126
Z9 144
U1 2
U2 25
PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3996 USA
EI 1083-351X
J9 J BIOL CHEM
JI J. Biol. Chem.
PD NOV 6
PY 2009
VL 284
IS 45
BP 30994
EP 31005
DI 10.1074/jbc.M109.050443
PG 12
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 514EZ
UT WOS:000271378400029
PM 19690167
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Yeudall, S
   Upchurch, CM
   Leitinger, N
AF Yeudall, Scott
   Upchurch, Clint M.
   Leitinger, Norbert
TI The clinical relevance of heme detoxification by the macrophage heme
   oxygenase system
SO FRONTIERS IN IMMUNOLOGY
LA English
DT Review
DE heme; oxidative stress; inflammation; ferroptosis; cardiometabolic
   disease; hemoglobin; iron; hemolysis
ID CARBON-MONOXIDE; MOUSE MODEL; TRANSCRIPTION FACTOR; PROMOTER
   POLYMORPHISM; IN-VIVO; SPI-C; IRON; INFLAMMATION; HEMOGLOBIN; HEMOLYSIS
AB Heme degradation by the heme oxygenase (HMOX) family of enzymes is critical for maintaining homeostasis and limiting heme-induced tissue damage. Macrophages express HMOX1 and 2 and are critical sites of heme degradation in healthy and diseased states. Here we review the functions of the macrophage heme oxygenase system and its clinical relevance in discrete groups of pathologies where heme has been demonstrated to play a driving role. HMOX1 function in macrophages is essential for limiting oxidative tissue damage in both acute and chronic hemolytic disorders. By degrading pro-inflammatory heme and releasing anti-inflammatory molecules such as carbon monoxide, HMOX1 fine-tunes the acute inflammatory response with consequences for disorders of hyperinflammation such as sepsis. We then discuss divergent beneficial and pathological roles for HMOX1 in disorders such as atherosclerosis and metabolic syndrome, where activation of the HMOX system sits at the crossroads of chronic low-grade inflammation and oxidative stress. Finally, we highlight the emerging role for HMOX1 in regulating macrophage cell death via the iron- and oxidation-dependent form of cell death, ferroptosis. In summary, the importance of heme clearance by macrophages is an active area of investigation with relevance for therapeutic intervention in a diverse array of human diseases.
C1 [Yeudall, Scott; Leitinger, Norbert] Univ Virginia, Sch Med, Dept Pharmacol, Charlottesville, VA 22903 USA.
   [Yeudall, Scott] Univ Virginia, Sch Med, Med Scientist Training Program, Charlottesville, VA USA.
   [Upchurch, Clint M.] Univ Virginia, Sch Med, Ctr Brain Immunol & Glia BIG, Dept Neurosci, Charlottesville, VA USA.
   [Leitinger, Norbert] Univ Virginia, Sch Med, Robert M Berne Cardiovasc Res Ctr, Charlottesville, VA 22903 USA.
C3 University of Virginia; University of Virginia; University of Virginia;
   University of Virginia
RP Leitinger, N (corresponding author), Univ Virginia, Sch Med, Dept Pharmacol, Charlottesville, VA 22903 USA.; Leitinger, N (corresponding author), Univ Virginia, Sch Med, Robert M Berne Cardiovasc Res Ctr, Charlottesville, VA 22903 USA.
EM nl2q@virginia.edu
FU NIH/NHLBI [F30 HL154554, R56 HL158886]; NIH/NIGMS [T32 GM007267, T32
   GM148379]
FX The author(s) declare financial support was received for the research,
   authorship, and/or publication of this article. SY was supported by F30
   HL154554 (from NIH/NHLBI), T32 GM007267 (from NIH/NIGMS), and T32
   GM148379 (from NIH/NIGMS). Work in the laboratory of NL is supported by
   R56 HL158886 (from NIH/NHLBI).
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NR 136
TC 4
Z9 4
U1 2
U2 6
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-3224
J9 FRONT IMMUNOL
JI Front. Immunol.
PD MAR 22
PY 2024
VL 15
AR 1379967
DI 10.3389/fimmu.2024.1379967
PG 11
WC Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology
GA MX3M9
UT WOS:001196896600001
PM 38585264
OA gold
DA 2025-06-11
ER

PT J
AU Hernández-Vázquez, E
   Salgado-Barrera, S
   Ramírez-Espinosa, JJ
   Estrada-Soto, S
   Hernández-Luis, F
AF Hernandez-Vazquez, Eduardo
   Salgado-Barrera, Sandybel
   Jose Ramirez-Espinosa, Juan
   Estrada-Soto, Samuel
   Hernandez-Luis, Francisco
TI Synthesis and molecular docking of
   N′-arylidene-5-(4-chlorophenyl)-1-(3,4-dichlorophenyl)-4-methyl-1
   H-pyrazole-3-carbohydrazides as novel hypoglycemic and
   antioxidant dual agents
SO BIOORGANIC & MEDICINAL CHEMISTRY
LA English
DT Article
DE Diarylpyrazole hybrids; Cannabinoid receptor 1; Antioxidant capacity;
   Antidiabetic effect; Molecular docking
ID CANNABINOID RECEPTOR 1; OXIDATIVE STRESS; CB1 RECEPTOR; ANALOGS;
   ANTAGONISTS; RIMONABANT; IRON; TARGET; MECHANISMS; BINDING
AB Herein, the design and synthesis of 10 novel N'-arylidene pyrazole-3-carbohydrazides are described. Compounds were pretended to act as dual agents against diabetes and oxidative stress, two correlated pathologies involved in metabolic syndrome development and progression. The antioxidant capacity was evaluated by means of DPPH and FRAP in vitro assays. It was found that compounds bearing a hydroxyl group at 4-position of the hydrazone moiety are potent antioxidant entities, being compound 3g (a syringaldehyde derivative) the most active compound. In addition, the in vivo hypoglycemic effect of the analogues was determined. With regard to the above, the cinnamaldehyde derivatives showed a scarce biological activity, while the 4-hydroxy analogues showed the higher glycemia reduction at 7 h after administration. Interestingly, the most potent antioxidants 3b and 3g also were of the most active compounds in reducing the plasma glucose, reaching 80% of reduction in the case of 3g. Molecular docking binding poses conducted to a plausible interpretation of the biological outcomes and a possible interaction between a hydroxy group and Asn287 of CB1R was proposed as an important feature for enhancing the observed activity. (C) 2016 Elsevier Ltd. All rights reserved.
C1 [Hernandez-Vazquez, Eduardo; Salgado-Barrera, Sandybel; Hernandez-Luis, Francisco] Univ Nacl Autonoma Mexico, Dept Farm, Fac Quim, Mexico City 04510, DF, Mexico.
   [Jose Ramirez-Espinosa, Juan; Estrada-Soto, Samuel] Univ Autonoma Estado Morelos, Fac Farm, Cuernavaca 62209, Morelos, Mexico.
C3 Universidad Nacional Autonoma de Mexico; Universidad Autonoma del Estado
   de Morelos
RP Hernández-Vázquez, E (corresponding author), Univ Nacl Autonoma Mexico, Dept Farm, Fac Quim, Mexico City 04510, DF, Mexico.
EM eduardo.hervaz@gmail.com
RI Hernández-Vázquez, Eduardo/AAV-5377-2021; Hernández-Luis,
   Francisco/AAU-9356-2021; Estrada-Soto, Samuel/AFQ-6053-2022;
   Hernandez-Luis, Francisco/O-8608-2014
OI Hernandez-Vazquez, Eduardo/0000-0002-0463-9448; Hernandez-Luis,
   Francisco/0000-0002-8724-9495; Estrada-Soto, Samuel/0000-0003-1860-0744;
   Ramirez-Espinosa, Juan Jose/0000-0003-2892-1955
FU Instituto de Ciencia y Tecnologia del Distrito Federal [ICYTDF235/2010];
    [216082]
FX Financial support from the Instituto de Ciencia y Tecnologia del
   Distrito Federal (ICYTDF235/2010) is acknowledged. Eduardo
   Hernandez-Vazquez is granted to the CONACYT for his fellowship (number
   216082). We also thank to Rosa Isela del Villar, Georgina Duarte,
   Margarita Guzman and Marisela Gutierrez for the analytical support.
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NR 51
TC 27
Z9 27
U1 0
U2 19
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0968-0896
EI 1464-3391
J9 BIOORGAN MED CHEM
JI Bioorg. Med. Chem.
PD MAY 15
PY 2016
VL 24
IS 10
BP 2298
EP 2306
DI 10.1016/j.bmc.2016.04.007
PG 9
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Chemistry,
   Organic
WE Science Citation Index Expanded (SCI-EXPANDED); Index Chemicus (IC)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Chemistry
GA DJ6OJ
UT WOS:000374332500013
PM 27079123
DA 2025-06-11
ER

PT J
AU McAninch, EA
   Fonseca, TL
   Poggioli, R
   Panos, AL
   Salerno, TA
   Deng, YP
   Li, Y
   Bianco, AC
   Iacobellis, G
AF McAninch, Elizabeth A.
   Fonseca, Tatiana L.
   Poggioli, Raffaella
   Panos, Anthony L.
   Salerno, Tomas A.
   Deng, Youping
   Li, Yan
   Bianco, Antonio C.
   Iacobellis, Gianluca
TI Epicardial adipose tissue has a unique transcriptome modified in severe
   coronary artery disease
SO OBESITY
LA English
DT Article
ID METABOLIC SYNDROME; IN-VIVO; INSULIN; FAT; EXPRESSION; GENE;
   ADIPOCYTOKINES; RESISTANCE; MEDIATORS; ADIPOKINE
AB ObjectiveTo explore the transcriptome of epicardial adipose tissue (EAT) as compared to subcutaneous adipose tissue (SAT) and its modifications in a small number of patients with coronary artery disease (CAD) versus valvulopathy.
   MethodsSAT and EAT samples were obtained during elective cardiothoracic surgeries. The transcriptome of EAT was evaluated, as compared to SAT, using an unbiased, whole-genome approach in subjects with CAD (n = 6) and without CAD (n = 5), where the patients without CAD had cardiac valvulopathy.
   ResultsRelative to SAT, EAT is a highly inflammatory tissue enriched with genes involved in endothelial function, coagulation, immune signaling, potassium transport, and apoptosis. EAT is lacking in expression of genes involved in protein metabolism, tranforming growth factor-beta (TGF-beta) signaling, and oxidative stress. Although underpowered, in subjects with severe CAD, there is an expression trend suggesting widespread downregulation of EAT encompassing a diverse group of gene sets related to intracellular trafficking, proliferation/transcription regulation, protein catabolism, innate immunity/lectin pathway, and ER stress.
   ConclusionsThe EAT transcriptome is unique when compared to SAT. In the setting of CAD versus valvulopathy, there is possible alteration of the EAT transcriptome with gene suppression. This pilot study explores the transcriptome of EAT in CAD and valvulopathy, providing new insight into its physiologic and pathophysiologic roles.
C1 [McAninch, Elizabeth A.; Fonseca, Tatiana L.; Bianco, Antonio C.] Rush Univ, Med Ctr, Div Endocrinol & Metab, Dept Med, Chicago, IL 60612 USA.
   [Poggioli, Raffaella; Iacobellis, Gianluca] Univ Miami, Miller Sch Med, Div Endocrinol Diabet & Metab, Dept Med, Miami, FL 33136 USA.
   [Panos, Anthony L.; Salerno, Tomas A.] Univ Miami, Miller Sch Med, Dept Surg, Div Thorac & Cardiac Surg, Miami, FL 33136 USA.
   [Deng, Youping; Li, Yan] Rush Univ, Med Ctr, Dept Med, Chicago, IL 60612 USA.
C3 Rush University; University of Miami; University of Miami; Rush
   University
RP Iacobellis, G (corresponding author), Univ Miami, Miller Sch Med, Div Endocrinol Diabet & Metab, Dept Med, Miami, FL 33136 USA.
EM giacobellis@med.miami.edu
RI McAninch, Elizabeth/AAF-6701-2020; Bianco, Antonio/AAK-6336-2020;
   Bianco, Antonio/A-4965-2008
OI Deng, Youping/0000-0002-5951-8213; McAninch,
   Elizabeth/0000-0003-3993-4663; Bianco, Antonio/0000-0001-7737-6813;
   Panos, Anthony/0000-0002-4208-1908
FU NIDDK NIH HHS [R01 DK065055, R01 DK077148] Funding Source: Medline
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NR 36
TC 96
Z9 98
U1 0
U2 6
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1930-7381
EI 1930-739X
J9 OBESITY
JI Obesity
PD JUN
PY 2015
VL 23
IS 6
BP 1267
EP 1278
DI 10.1002/oby.21059
PG 12
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA CJ0FG
UT WOS:000355150300020
PM 25959145
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Day, CP
AF Day, C. P.
TI Genes or environment to determine alcoholic liver disease and
   non-alcoholic fatty liver disease
SO LIVER INTERNATIONAL
LA English
DT Review
DE alcoholic liver disease; fatty liver disease; genes; NASH; polymorphisms
ID PROLIFERATOR-ACTIVATED RECEPTOR; NECROSIS-FACTOR-ALPHA;
   INSULIN-RESISTANCE; PROMOTER POLYMORPHISM; SUPEROXIDE-DISMUTASE; HEPATIC
   STEATOSIS; OXIDATIVE STRESS; RISK; STEATOHEPATITIS; ASSOCIATION
AB While the vast majority of heavy drinkers and individuals with obesity, insulin resistance, and the metabolic syndrome will have steatosis, only a minority will ever develop steatohepatitis, fibrosis, and cirrhosis. Genetic and environmental risk factors for advanced alcoholic liver disease (ALD) and non-alcoholic fatty liver disease (NAFLD) seem likely to include factors that influence the severity of steatosis and oxidative stress, the cytokine milieu, the magnitude of the immune response, and/or the severity of fibrosis. For ALD, the dose and pattern of alcohol intake, along with obesity are the most important environmental factors determining disease risk. For NAFLD, dietary saturated fat and antioxidant intake and small bowel bacterial overgrowth may play a role. Family studies and interethnic variations in susceptibility suggest that genetic factors are important in determining disease risk. For ALD, functional polymorphisms in the alcohol dehydrogenases and aldehyde dehydrogenase alcohol metabolising genes play a role in determining susceptibility in Oriental populations. No genetic associations with advanced NAFLD have been replicated in large studies. Preliminary data suggest that polymorphisms in the genes encoding microsomal triglyceride transfer protein, superoxide dismutase 2, the CD14 endotoxin receptor, TNF-alpha, transforming growth factor-beta, and angiotensinogen may be associated with steatohepatitis and/or fibrosis.
C1 Univ Newcastle, Inst Cellular Med, Sch Med, Liver Grp, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England.
C3 Newcastle University - UK
RP Day, CP (corresponding author), Univ Newcastle, Inst Cellular Med, Sch Med, Liver Grp, Floor 4 William Leech Bldg,Framlington Pl, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England.
EM c.p.day@ncl.ac.uk
RI Day, Christopher/Z-3305-2019
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NR 62
TC 132
Z9 148
U1 2
U2 21
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1478-3223
EI 1478-3231
J9 LIVER INT
JI Liver Int.
PD NOV
PY 2006
VL 26
IS 9
BP 1021
EP 1028
DI 10.1111/j.1478-3231.2006.01323.x
PG 8
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 093HA
UT WOS:000241157700001
PM 17032401
OA Bronze
DA 2025-06-11
ER

PT J
AU Girard, A
   Madani, S
   Boukortt, F
   Cherkaoui-Malki, M
   Belleville, J
   Prost, J
AF Girard, Aurelie
   Madani, Sihem
   Boukortt, Farida
   Cherkaoui-Malki, Mustapha
   Belleville, Jacques
   Prost, Josiane
TI Fructose-enriched diet modifies antioxidant status and lipid metabolism
   in spontaneously hypertensive rats
SO NUTRITION
LA English
DT Article
DE hypertension; fructose; antioxidant status; insulin resistance; syndrome
   X
ID PERFORMANCE LIQUID-CHROMATOGRAPHY; INSULIN-RESISTANCE; VITAMIN-E;
   DEFENSE SYSTEM; ENDOTHELIAL DYSFUNCTION; OXIDATIVE STRESS; INACTIVATION;
   GLUTATHIONE; CATALASE; COMPLICATIONS
AB Objective: High-fructose consumption in industrial countries has been shown to induce metabolic abnormalities or syndrome X. Changes in antioxidant defense are unknown in hypertension associated with metabolic disorders induced by high-fructose feeding.
   Methods: Twenty spontaneously hypertensive rats were assigned to one of two groups; one received a fructose-enriched diet (60% fructose) and the other a starch diet. After a 13-wk diet period, total antioxidant status was assessed in the blood and,liver by monitoring the rate of free radical-induced red blood cell hemolysis. Antioxidants (enzymes and vitamins) were determined in blood and liver. Gene expression of antioxidant enzymes (copper/zinc superoxide dismutase and glutathione peroxidase) were also investigated in hepatic tissue.
   Results: Fructose-fed rats showed blood pressure values similar to that of control rats but had increased glycemia and insulinemia. The antioxidant capacity in the blood of the fructose-fed group represented by copper/zinc superoxide dismutase and glutathione peroxidase activities and ascorbic acid was lower. However, the fructose diet enhanced the total antioxidant capacity of liver correlated with increased antioxidant enzyme activities and retinol concentrations. Gutathione peroxidase mRNA expression was decreased in livers of spontaneously hypertensive rats fed the fructose diet.
   Conclusion: Fructose feeding negatively affects antioxidant capacity in the blood of hypertensive rats but improves this capacity in the liver. (C) 2006 Elsevier Inc. All rights reserved.
C1 Univ Bourgogne, Fac Sci Gabriel, UPRES Lipides Nutr, Dijon, France.
   Univ Oran Es Senia, Fac Sci, Lab Nutr Clin & Metab, Oran, Algeria.
   Univ Bourgogne, Fac Sci Gabriel, Biol Cellulaire & Mol Lab, Dijon, France.
C3 Universite Bourgogne Europe; Universite d'Oran; Universite Bourgogne
   Europe
RP Girard, A (corresponding author), Univ Bourgogne, Fac Sci Gabriel, UPRES Lipides Nutr, EA 2422, Dijon, France.
EM aurelie.girard@u-bourgogne.fr
RI Boukortt, Farida/AAE-7707-2019; Cherkaoui-Malki, Mustapha/B-2412-2012
OI Boukortt, Farida/0000-0003-2654-800X; Cherkaoui-Malki,
   Mustapha/0000-0001-5010-739X
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NR 46
TC 80
Z9 85
U1 0
U2 3
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0899-9007
EI 1873-1244
J9 NUTRITION
JI Nutrition
PD JUL-AUG
PY 2006
VL 22
IS 7-8
BP 758
EP 766
DI 10.1016/j.nut.2006.05.006
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 064OM
UT WOS:000239099000009
PM 16815490
DA 2025-06-11
ER

PT J
AU Li, L
   Ren, FY
   Qi, C
   Xu, LQ
   Fang, YS
   Liang, ML
   Feng, J
   Chen, BY
   Ning, W
   Cao, J
AF Li, Lian
   Ren, Fangyuan
   Qi, Chao
   Xu, Leiqian
   Fang, Yinshan
   Liang, Maoli
   Feng, Jing
   Chen, Baoyuan
   Ning, Wen
   Cao, Jie
TI Intermittent hypoxia promotes melanoma lung metastasis via oxidative
   stress and inflammation responses in a mouse model of obstructive sleep
   apnea
SO RESPIRATORY RESEARCH
LA English
DT Article
DE Obstructive sleep apnea; Intermittent hypoxia; Lung metastasis;
   Oxidative stress; Inflammation; Antioxidant tempol
ID CANCER-RELATED INFLAMMATION; NF-KAPPA-B; METABOLIC SYNDROME;
   GENE-EXPRESSION; NADPH OXIDASE; CELLS; TEMPOL; PROGRESSION; PROTEIN;
   COHORT
AB Background: Recently, increased tumor incidence and cancer-related mortality have been reported among patients with obstructive sleep apnea (OSA). Intermittent hypoxia (IH), the hallmark feature of OSA, contributes to the metastasis of tumors. However, the molecular mechanisms by which tumor metastasis is accelerated by OSA-like IH remain to be elucidated.
   Methods: C57BL/6 J male mice were subjected to intravenous injection of B16F10 melanoma cells before receiving IH treatment. Then, the animals were randomly distributed into three groups (n = 8 each): normoxia (N) group, IH group, and antioxidant tempol group (IHT, exposed to IH after treatment with tempol). After the mice were sacrificed, the number and weight of lung metastatic colonies were assessed. The lung tissues with tumor metastasis were analyzed for markers of oxidative stress and inflammation and for HIF-1 alpha using western blotting and real-time PCR (qRT-PCR). The level of reactive oxygen species (ROS) in B16F10 cell was also assessed after N, IH and IH with tempol treatments.
   Results: Compared with normoxia, IH significantly increased the number and weight of mouse lung metastatic colonies. Treatment of B16F10 cells with IH significantly enhanced ROS generation. Lung tissues with tumor metastasis provided evidence of increased oxidative stress, as assessed by p22(phox) and SOD mRNA levels and the NRF2 protein level, as well as increased inflammation, as assessed by TNF-alpha and IL-6 mRNA levels and the NF-kappa BP 65 protein level. HIF-1 alpha protein levels were increased in response to IH treatment. Tempol, an important antioxidant, ameliorated IH-induced melanoma lung metastasis in mice and reduced oxidative stress and inflammation responses.
   Conclusions: These results support the hypothesis that oxidative stress and inflammation responses play an important role in the pathogenesis of OSA-like IH-induced melanoma lung metastasis in mice. Antioxidant intervention provides a novel strategy for the prevention and treatment of cancer in OSA populations.
C1 [Qi, Chao; Fang, Yinshan; Ning, Wen] Nankai Univ, Coll Life Sci, State Key Lab Med Chem Biol, Tianjin, Peoples R China.
   [Li, Lian; Ren, Fangyuan; Xu, Leiqian; Liang, Maoli; Feng, Jing; Chen, Baoyuan; Cao, Jie] Tianjin Med Univ Gen Hosp, Resp Dept, Tianjin, Peoples R China.
C3 Nankai University; Tianjin Medical University
RP Ning, W (corresponding author), Nankai Univ, Coll Life Sci, State Key Lab Med Chem Biol, Tianjin, Peoples R China.; Cao, J (corresponding author), Tianjin Med Univ Gen Hosp, Resp Dept, Tianjin, Peoples R China.
EM ningwen108@nankai.edu; tjcaojie123@163.com
RI li, lianling/LVS-4194-2024; Cao, jie/JXR-6551-2024; Chen,
   Luzeng/AAW-4390-2021; Fang, Yinshan/AAU-4250-2021
FU National Natural Science Foundation of China [81500070, 81670084];
   Tianjin Medical University General Hospital for Young Scholars
   [ZYYFY2014011]
FX This study was supported by the grants from the National Natural Science
   Foundation of China (No. 81500070 and 81670084), and grants from Tianjin
   Medical University General Hospital for Young Scholars (ZYYFY2014011).
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NR 55
TC 75
Z9 82
U1 0
U2 15
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1465-993X
EI 1465-9921
J9 RESP RES
JI Respir. Res.
PD FEB 12
PY 2018
VL 19
AR 28
DI 10.1186/s12931-018-0727-x
PG 9
WC Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Respiratory System
GA FV7OI
UT WOS:000424773700001
PM 29433520
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Warda, M
   Tekin, S
   Gamal, M
   Khafaga, N
   Çelebi, F
   Tarantino, G
AF Warda, Mohamad
   Tekin, Samet
   Gamal, Mahmoud
   Khafaga, Nagwa
   Celebi, Fikret
   Tarantino, Giovanni
TI Lipid rafts: novel therapeutic targets for metabolic, neurodegenerative,
   oncological, and cardiovascular diseases
SO LIPIDS IN HEALTH AND DISEASE
LA English
DT Review
DE Lipid rafts; Cellular crosstalk; Metabolic syndrome; Neurodegenerative
   disorders; Cardiovascular disease; Therapeutic targets
ID MEMBRANE; ASSOCIATION; PROTEIN; HEAT-SHOCK-PROTEIN-70; CAVEOLAE;
   BIOLOGY; MYSTERY; IMMUNE; GROWTH; ROLES
AB Lipid rafts are specialized microdomains within cellular membranes enriched with cholesterol and sphingolipids that play key roles in cellular organization, signaling, and homeostasis. This review highlights their involvement in protein clustering, energy metabolism, oxidative stress responses, inflammation, autophagy, and apoptosis. These findings clarify their influence on signaling, trafficking, and adhesion while interacting with the extracellular matrix, cytoskeleton, and ion channels, making them pivotal in the progression of various diseases. This review further addresses their contributions to immune responses, including autoimmune diseases, chronic inflammation, and cytokine storms. Additionally, their role as entry points for pathogens has been demonstrated, with raft-associated receptors being exploited by viruses and bacteria to increase infectivity and evade immune defenses. Disruptions in lipid raft dynamics are linked to oxidative stress and cellular signaling defects, which contribute to metabolic, neurodegenerative, and cardiovascular diseases. This review underscores their potential as therapeutic targets, discussing innovations such as engineered lipid raft transplantation. Advances in analytical techniques such as mass spectrometry have expanded our understanding of lipid raft composition and dynamics, opening new directions for research. By consolidating the current insights, we highlight the therapeutic potential of lipid rafts and highlight the need for further exploration of their molecular mechanisms.
C1 [Warda, Mohamad; Tekin, Samet; Celebi, Fikret] Ataturk Univ, Fac Vet Med, Dept Physiol, Erzurum, Turkiye.
   [Warda, Mohamad; Gamal, Mahmoud] Cairo Univ, Fac Vet Med, Dept Biochem, Giza, Egypt.
   [Khafaga, Nagwa] Agr Res Ctr ARC, Anim Hlth Res Inst AHRI, Food Hyg Dept, Dokki, Egypt.
   [Tarantino, Giovanni] Federico II Univ Med Sch Naples, Dept Clin Med & Surg, Naples, Italy.
C3 Ataturk University; Egyptian Knowledge Bank (EKB); Cairo University;
   Animal Health Research Institute (AHRI); University of Naples Federico
   II
RP Warda, M (corresponding author), Ataturk Univ, Fac Vet Med, Dept Physiol, Erzurum, Turkiye.; Warda, M (corresponding author), Cairo Univ, Fac Vet Med, Dept Biochem, Giza, Egypt.; Tarantino, G (corresponding author), Federico II Univ Med Sch Naples, Dept Clin Med & Surg, Naples, Italy.
EM mohamad.warda@atauni.edu.tr; tarantin@unina.it
RI TEKIN, Samet/AHH-9196-2022; Çelebi, Fikret/AAG-6943-2019
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NR 168
TC 1
Z9 1
U1 2
U2 2
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1476-511X
J9 LIPIDS HEALTH DIS
JI Lipids Health Dis.
PD APR 17
PY 2025
VL 24
IS 1
AR 147
DI 10.1186/s12944-025-02563-0
PG 23
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA 1NO7P
UT WOS:001469272100001
PM 40247292
DA 2025-06-11
ER

PT J
AU Lanaspa, MA
   Ishimoto, T
   Cicerchi, C
   Tamura, Y
   Roncal-Jimenez, CA
   Chen, W
   Tanabe, K
   Andres-Hernando, A
   Orlicky, DJ
   Finol, E
   Inaba, S
   Li, NX
   Rivard, CJ
   Kosugi, T
   Sanchez-Lozada, LG
   Petrash, JM
   Sautin, YY
   Ejaz, AA
   Kitagawa, W
   Garcia, GE
   Bonthron, DT
   Asipu, A
   Diggle, CP
   Rodriguez-Iturbe, B
   Nakagawa, T
   Johnson, RJ
AF Lanaspa, Miguel A.
   Ishimoto, Takuji
   Cicerchi, Christina
   Tamura, Yoshifuru
   Roncal-Jimenez, Carlos A.
   Chen, Wei
   Tanabe, Katsuyuki
   Andres-Hernando, Ana
   Orlicky, David J.
   Finol, Esteban
   Inaba, Shinichiro
   Li, Nanxing
   Rivard, Christopher J.
   Kosugi, Tomoki
   Sanchez-Lozada, Laura G.
   Petrash, J. Mark
   Sautin, Yuri Y.
   Ejaz, A. Ahsan
   Kitagawa, Wataru
   Garcia, Gabriela E.
   Bonthron, David T.
   Asipu, Aruna
   Diggle, Christine P.
   Rodriguez-Iturbe, Bernardo
   Nakagawa, Takahiko
   Johnson, Richard J.
TI Endogenous Fructose Production and Fructokinase Activation Mediate Renal
   Injury in Diabetic Nephropathy
SO JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
LA English
DT Article
ID INDUCED METABOLIC SYNDROME; PROXIMAL TUBULAR CELLS; URIC-ACID;
   GLOMERULAR HYPERTENSION; ALDOSE REDUCTASE; OXIDATIVE STRESS; KAPPA-B;
   TUBULOINTERSTITIAL INJURY; KIDNEY-DISEASE; DB/DB MICE
AB Diabetes is associated with activation of the polyol pathway, in which glucose is converted to sorbitol by aldose reductase. Previous studies focused on the role of sorbitol in mediating diabetic complications. However, in the proximal tubule, sorbitol can be converted to fructose, which is then metabolized largely by fructokinase, also known as ketohexokinase, leading to ATP depletion, proinflammatory cytokine expression, and oxidative stress. We and others recently identified a potential deleterious role of dietary fructose in the generation of tubulointerstitial injury and the acceleration of CKD. In this study, we investigated the potential role of endogenous fructose production, as opposed to dietary fructose, and its metabolism through fructokinase in the development of diabetic nephropathy. Wild-type mice with streptozotocin-induced diabetes developed proteinuria, reduced GFR, and renal glomerular and proximal tubular injury. Increased renal expression of aldose reductase; elevated levels of renal sorbitol, fructose, and uric acid; and low levels of ATP confirmed activation of the fructokinase pathway. Furthermore, renal expression of inflammatory cytokines with macrophage infiltration was prominent. In contrast, diabetic fructokinase-deficient mice demonstrated significantly less proteinuria, renal dysfunction, renal injury, and inflammation. These studies identify fructokinase as a novel mediator of diabetic nephropathy and document a novel role for endogenous fructose production, or fructoneogenesis, in driving renal disease.
C1 [Lanaspa, Miguel A.; Ishimoto, Takuji; Cicerchi, Christina; Tamura, Yoshifuru; Roncal-Jimenez, Carlos A.; Chen, Wei; Tanabe, Katsuyuki; Andres-Hernando, Ana; Orlicky, David J.; Finol, Esteban; Inaba, Shinichiro; Li, Nanxing; Rivard, Christopher J.; Sanchez-Lozada, Laura G.; Petrash, J. Mark; Kitagawa, Wataru; Garcia, Gabriela E.; Nakagawa, Takahiko; Johnson, Richard J.] Univ Colorado, Dept Med, Div Renal Dis & Hypertens, Denver, CO USA.
   [Finol, Esteban; Rodriguez-Iturbe, Bernardo] Venezuelan Sci Res Inst, Maracaibo, Venezuela.
   [Finol, Esteban; Rodriguez-Iturbe, Bernardo] Univ Hosp Zulia, Maracaibo, Venezuela.
   [Kosugi, Tomoki] Nagoya Univ, Grad Sch Med, Dept Nephrol, Nagoya, Aichi 4648601, Japan.
   [Sanchez-Lozada, Laura G.] INC Ignacio Chavez, Lab Renal Physiopathol, Mexico City, DF, Mexico.
   [Sanchez-Lozada, Laura G.] INC Ignacio Chavez, Dept Nephrol, Mexico City, DF, Mexico.
   [Sautin, Yuri Y.] Univ Florida, Div Nephrol & Hypertens, Gainesville, FL USA.
   [Ejaz, A. Ahsan] Univ Florida, Div Nephrol Hypertens & Transplantat, Gainesville, FL USA.
   [Bonthron, David T.; Asipu, Aruna; Diggle, Christine P.] Univ Leeds, Leeds Inst Biomed & Clin Sci, Leeds, W Yorkshire, England.
   [Nakagawa, Takahiko] Kyoto Univ, Grad Sch Med, TMK Project, Kyoto, Japan.
C3 University of Colorado System; University of Colorado Anschutz Medical
   Campus; University of Colorado Denver; Nagoya University; State
   University System of Florida; University of Florida; State University
   System of Florida; University of Florida; University of Leeds; Kyoto
   University
RP Lanaspa, MA (corresponding author), 12700 East 19th Ave,C-281, Aurora, CO 80045 USA.
EM Miguel.lanaspagarcia@ucdenver.edu
RI Rodriguez-Iturbe, Bernardo/KFX-2910-2024; Tanabe, Katsuyuki/J-1341-2019;
   Lanaspa, Miguel/AAO-4971-2020; Sanchez-Lozada, Laura/AAS-2104-2021;
   Finol Berrueta, Esteban Andres/ABA-5146-2020; Ishimoto,
   Takuji/M-4873-2014
OI Sanchez-Lozada, Laura-Gabriela/0000-0003-0348-9617; Finol Berrueta,
   Esteban Andres/0000-0002-9830-439X; Bonthron, David/0000-0001-8132-8179;
   Ishimoto, Takuji/0000-0002-9861-5331; Andres-Hernando,
   Ana/0000-0002-0676-0188
FU National Institutes of Health [HL-68607, RC4-DK090859-01,
   1K01-DK095930-01, RO1-DK082509]; University of Colorado; Diabetes UK
   (UK);  [RD04/0002833]
FX This work was supported by grants HL-68607 and RC4-DK090859-01 (to
   R.J.J.), grant 1K01-DK095930-01 (to M.A.L.), and grant RO1-DK082509 (to
   G.G.) from the National Institutes of Health, Diabetes UK (UK), grant
   RD04/0002833, and startup funds from the University of Colorado.
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NR 46
TC 121
Z9 131
U1 2
U2 25
PU AMER SOC NEPHROLOGY
PI WASHINGTON
PA 1725 I ST, NW STE 510, WASHINGTON, DC 20006 USA
SN 1046-6673
EI 1533-3450
J9 J AM SOC NEPHROL
JI J. Am. Soc. Nephrol.
PD NOV
PY 2014
VL 25
IS 11
BP 2526
EP 2538
DI 10.1681/ASN.2013080901
PG 13
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA AS1KO
UT WOS:000344040300016
PM 24876114
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Miller, AA
   Spencer, SJ
AF Miller, Alyson A.
   Spencer, Sarah J.
TI Obesity and neuroinflammation: A pathway to cognitive impairment
SO BRAIN BEHAVIOR AND IMMUNITY
LA English
DT Article
DE Cognition; High fat diet; Hypothalamus; Inflammation; Obesity
ID BODY-MASS INDEX; ENDOPLASMIC-RETICULUM STRESS; HIGH-FAT DIET; INDUCED
   INSULIN-RESISTANCE; PITUITARY-ADRENAL AXIS; NECROSIS-FACTOR-ALPHA;
   LATE-LIFE OBESITY; OXIDATIVE STRESS; SYSTEMIC INFLAMMATION; METABOLIC
   SYNDROME
AB Obesity is a growing problem worldwide and is associated with a range of comorbidities, including cognitive dysfunction. In this review we will address the evidence that obesity and high fat feeding can lead to cognitive dysfunction. We will also examine the idea that obesity-associated systemic inflammation leads to inflammation within the brain, particularly the hypothalamus, and that this is partially responsible for these negative cognitive outcomes. Thus, obesity, and high fat feeding, lead to systemic inflammation and excess circulating free fatty acids. Circulating cytokines, free fatty acids and immune cells reach the brain at the level of the hypothalamus and initiate local inflammation, including microglial proliferation. This local inflammation likely causes synaptic remodeling and neurodegeneration within the hypothalamus, altering internal hypothalamic circuitry and hypothalamic outputs to other brain regions. The result is disruption to cognitive function mediated by regions such as hippocampus, amygdala, and reward-processing centers. Central inflammation is also likely to affect these regions directly. Thus, central inflammation in obesity leads not just to disruption of hypothalamic satiety signals and perpetuation of overeating, but also to negative outcomes on cognition. (C) 2014 Elsevier Inc. All rights reserved.
C1 [Miller, Alyson A.] RMIT Univ, Sch Med Sci, Melbourne, Vic 3083, Australia.
   [Miller, Alyson A.; Spencer, Sarah J.] RMIT Univ, Hlth Innovat Res Inst, Melbourne, Vic 3083, Australia.
   [Spencer, Sarah J.] RMIT Univ, Sch Hlth Sci, Melbourne, Vic 3083, Australia.
C3 Royal Melbourne Institute of Technology (RMIT); Royal Melbourne
   Institute of Technology (RMIT); Royal Melbourne Institute of Technology
   (RMIT)
RP Spencer, SJ (corresponding author), RMIT Univ, Sch Hlth Sci, Melbourne, Vic 3083, Australia.
EM Sarah.Spencer@rmit.edu.au
RI Spencer, Sarah/D-5777-2018
OI Spencer, Sarah/0000-0001-8832-4824
FU Australian Research Council (ARC) [DP130100508]; National Health and
   Medical Research Council (NHMRC) [APP1068442]
FX This work was supported by a Discovery Project Grant from the Australian
   Research Council (ARC) to SJS (DP130100508), and a Project Grant from
   the National Health and Medical Research Council (NHMRC) to AAM and SJS
   (APP1068442). SJS is an ARC Future Fellow (FT110100084) and an RMIT
   University VC Senior Research Fellow. AAM is an RMIT University VC
   Senior Research Fellow.
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NR 203
TC 551
Z9 603
U1 13
U2 165
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0889-1591
EI 1090-2139
J9 BRAIN BEHAV IMMUN
JI Brain Behav. Immun.
PD NOV
PY 2014
VL 42
BP 10
EP 21
DI 10.1016/j.bbi.2014.04.001
PG 12
WC Immunology; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Immunology; Neurosciences & Neurology; Psychiatry
GA AS7IK
UT WOS:000344429900003
PM 24727365
DA 2025-06-11
ER

PT J
AU Sánchez-de-la-Torre, M
   Campos-Rodriguez, F
   Barbé, F
AF Sanchez-de-la-Torre, Manuel
   Campos-Rodriguez, Francisco
   Barbe, Ferran
TI Obstructive sleep apnoea and cardiovascular disease
SO LANCET RESPIRATORY MEDICINE
LA English
DT Review
ID POSITIVE AIRWAY PRESSURE; CORONARY-ARTERY-DISEASE; CHRONIC
   HEART-FAILURE; ALL-CAUSE MORTALITY; BLOOD-PRESSURE; OXIDATIVE STRESS;
   NOCTURNAL ARRHYTHMIAS; METABOLIC SYNDROME; CONTROLLED-TRIAL; RISK-FACTOR
AB Obstructive sleep apnoea (OSA) is a common health concern caused by repeated episodes of collapse of the upper airway during sleep. The events associated with OSA lead to brain arousal, intrathoracic pressure changes, and intermittent episodes of hypoxaemia and reoxygenation. These events activate pathways such as oxidative stress, sympathetic activation, inflammation, hypercoagulability, endothelial dysfunction, and metabolic dysregulation that predispose patients with OSA to hypertension and atherosclerosis. OSA is a common cause of systemic hypertension and should be suspected in hypertensive individuals, especially those with resistant hypertension. In patients with OSA, continuous positive airway pressure (CPAP) treatment reduces blood pressure, and its effects are related to compliance and baseline blood pressure. Evidence suggests that OSA is a risk factor for stroke and heart failure. An association between coronary heart disease and OSA seem to be limited to middle-aged men (30-70 years): Cardiac rhythm disorders Occur in about half of patients with OSA, but their clinical relevance is still unknown. The association of OSA with cardiovascular risk is mainly based on studies in men, and an association has yet,to be established in women. Data on older patients is similarly scarce. Currently, there is not enough evidence to support treatment with CPAP for primary or secondary prevention of cardiovascular disease.
C1 [Sanchez-de-la-Torre, Manuel; Barbe, Ferran] Hosp Univ Arnau Vilanova Santa Maria, IRB Lleida, Resp Dept, Lleida, Catalonia, Spain.
   [Sanchez-de-la-Torre, Manuel; Barbe, Ferran] Ctr Invest Biomed Red Enfermedades Resp CIBERES, Madrid, Spain.
   [Campos-Rodriguez, Francisco] Valme Univ Hosp, Resp Dept, Sleep Disordered Breathing Unit, Seville, Spain.
C3 University Hospital Arnau de Vilanova; Institut de Recerca Biomedica -
   IRB Lleida; CIBER - Centro de Investigacion Biomedica en Red; CIBERES;
   Hospital Valme
RP Barbé, F (corresponding author), Univ Lleida, IRB Lleida, Hosp Univ Arnau Vilanova Santa Maria, Resp Dept, Lleida 25198, Spain.
EM fbarbe@arnau.scs.es
RI Sanchez-de-la-Torre, Manuel/AAP-2663-2020; Sanchez-de-la-Torre,
   Manuel/B-5578-2009; Barbe, Ferran/A-5988-2010
OI Campos-Rodriguez, Francisco/0000-0002-2632-3073; Sanchez-de-la-Torre,
   Manuel/0000-0002-5695-348X; Barbe, Ferran/0000-0002-2340-8928
FU ResMed Inc, Australia; Health Research Fund, Spanish Ministry of Health
FX FB has received a research grant from ResMed Inc, Australia, a company
   that develops products related to sleep apnoea, and support from the
   Health Research Fund, Spanish Ministry of Health, to develop clinical
   trials. All other authors declare that they have no conflicts of
   interest.
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NR 113
TC 381
Z9 399
U1 1
U2 56
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 2213-2600
J9 LANCET RESP MED
JI Lancet Resp. Med.
PD MAR
PY 2013
VL 1
IS 1
BP 61
EP 72
DI 10.1016/S2213-2600(12)70051-6
PG 12
WC Critical Care Medicine; Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Respiratory System
GA AE1XU
UT WOS:000333767900019
PM 24321805
DA 2025-06-11
ER

PT J
AU Bechtold, AG
   Vernon, K
   Hines, T
   Scheuer, DA
AF Bechtold, Andrea G.
   Vernon, Kathy
   Hines, Tina
   Scheuer, Deborah A.
TI Genetic predisposition to hypertension sensitizes borderline
   hypertensive rats to the hypertensive effects of prenatal glucocorticoid
   exposure
SO JOURNAL OF PHYSIOLOGY-LONDON
LA English
DT Article
ID SYSTOLIC BLOOD-PRESSURE; LOW-BIRTH-WEIGHT; CATCH-UP GROWTH; FETAL
   ORIGINS; IN-UTERO; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   NEUROPEPTIDE-Y; LAST WEEK; STRESS
AB An adverse intrauterine environment can increase the incidence of hypertension and other cardiovascular disease risk factors. However, in clinical and experimental studies the magnitude of the effect is variable. Possibly, the relative influence of the prenatal environment on cardiovascular disease is determined in part by genetic factors that predispose individuals to the development of environmentally induced hypertension. We tested this hypothesis by comparing the effects of prenatal dexamethasone treatment (Dex, 300 mu g kg(-1) I.P. on days 15 and 16 of gestation) in borderline hypertensive rats (BHR) and control Wistar-Kyoto (WKY) rats. Blood pressure, heart rate and plasma corticosterone values were measured at rest during the middle of the day, and during I h of restraint stress in the adult offspring using indwelling arterial catheters implanted at least 4 days prior to data collection. Compared with the saline (vehicle) control treatment, prenatal dexamethasone significantly (P < 0.05) increased baseline mean arterial pressure in male (123 +/- 2 versus 131 +/- 3 mmHg, saline versus Dex) and female (121 +/- 2 versus 130 +/- 2 mmHg, saline versus Dex) BHR, but not in male (108 +/- 3 versus 113 +/- 2 mmHg, saline versus Dex) or female (112 +/- 2 versus 110 +/- 2 mmHg, saline versus Dex) WKY rats. Relative to saline treatment, prenatal Dex also significantly increased baseline heart rate (328 +/- 6 versus 356 +/- 5 beats min(-1), saline versus Dex) and plasma corticosterone (5 +/- 2 versus 24 +/- 4 mu g dl(-1), saline versus Dex), and prolonged the corticosterone response to acute stress, selectively in female BHR. However, prenatal Dex significantly enhanced the arterial pressure response to acute stress only in female WKY, while Dex augmented the elevation in heart rate during stress only in male rats. We conclude that prenatal dexamethasone increased baseline arterial pressure selectively in BHR, and plasma corticosterone only in female BHR. In contrast, prenatal Dex enhanced cardiovascular reactivity to stress in both BHR and WKY rats.
C1 [Bechtold, Andrea G.] Univ Calif Davis, Dept Med Pharmacol, Davis, CA 95616 USA.
   [Vernon, Kathy] Univ Missouri, Sch Med, Kansas City, MO 64108 USA.
   [Hines, Tina] Univ Missouri, Sch Nursing, Kansas City, MO 64108 USA.
   [Scheuer, Deborah A.] Univ Florida, Dept Physiol & Funct Genom, Gainesville, FL 32610 USA.
C3 University of California System; University of California Davis;
   University of Missouri System; University of Missouri Kansas City;
   University of Missouri System; University of Missouri Kansas City; State
   University System of Florida; University of Florida
RP Bechtold, AG (corresponding author), Univ Calif Davis, Dept Med Pharmacol, Davis, CA 95616 USA.
FU NHLBI NIH HHS [R01 HL 076807, R01 HL076807] Funding Source: Medline
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NR 57
TC 5
Z9 6
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-3751
EI 1469-7793
J9 J PHYSIOL-LONDON
JI J. Physiol.-London
PD JAN 15
PY 2008
VL 586
IS 2
BP 673
EP 684
DI 10.1113/jphysiol.2007.141580
PG 12
WC Neurosciences; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Physiology
GA 255SX
UT WOS:000252678800029
PM 18006585
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Guan, XN
   Chen, YP
   Wang, X
   Xiu, MH
   Wu, FC
   Zhang, XY
AF Guan, Xiaoni
   Chen, Yuping
   Wang, Xin
   Xiu, Meihong
   Wu, Fengchun
   Zhang, Xiangyang
TI Total antioxidant capacity, obesity and clinical correlates in
   first-episode and drug-naïve patients with schizophrenia
SO SCHIZOPHRENIA RESEARCH
LA English
DT Article
DE Schizophrenia; Overweight/obesity; Negative symptom; Antioxidants; Total
   antioxidant status
ID OXIDATIVE STRESS; SUPEROXIDE-DISMUTASE; METABOLIC SYNDROME; COGNITIVE
   IMPAIRMENTS; REDOX DYSREGULATION; NEGATIVE SYNDROME; WEIGHT-GAIN;
   ASSOCIATION; PREVALENCE; MECHANISMS
AB Background: Overweight/obesity is a growing concern in schizophrenia (SZ). A few studies have shown that excessive oxidative stress and abnormal antioxidants were associated with pathogenesis and psychiatric symptoms in first episode antipsychotics naive (FEAN) patients with SZ. However, there is no study has explored the interrelationships between total antioxidant status (TAS) and the severity of psychiatric symptoms in the early stage of SZ. This study aimed to evaluate the impact of overweight/obesity on psychiatric symptoms in FEAN patients with SZ.Methods: A total of 241 patients with FEAN SZ and 119 healthy controls were recruited and symptoms were evaluated by the Positive and Negative Syndrome Scale (PANSS). TAS levels were also measured in patients and healthy controls.Results: We found a significant negative association between body mass index (BMI) and TAS in FEAN patients, but not in controls. In addition, BMI and TAS were negatively associated with psychiatric symptoms. Interestingly, further regression analysis revealed that the interaction between BMI and TAS was associated with the negative symptoms in the early stage of SZ.Conclusions: Our study indicates that abnormal TAS levels interacting with overweight/obesity may be involved in the pathophysiology of SZ, in particular negative symptoms.
C1 [Guan, Xiaoni; Xiu, Meihong] Peking Univ, Beijing Huilongguan Hosp, HuiLongGuan Clin Med Sch, Beijing, Peoples R China.
   [Chen, Yuping; Wang, Xin] Qingdao Mental Hlth Ctr, Qingdao, Peoples R China.
   [Wu, Fengchun; Zhang, Xiangyang] Guangzhou Med Univ, Dept Psychiat, Affiliated Brain Hosp, Guangzhou, Peoples R China.
   [Wu, Fengchun] Guangdong Engn Technol Res Ctr Translat Med Mental, Guangzhou, Peoples R China.
   [Wu, Fengchun] Guangzhou Med Univ, Dept Biomed Engn, Guangzhou, Peoples R China.
   [Zhang, Xiangyang] Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China.
   [Wu, Fengchun] Liwan Dist, Guangzhou 510370, Peoples R China.
   [Zhang, Xiangyang] 16 Lincui Rd,Chaoyang Dist, Beijing 100101, Peoples R China.
C3 Peking University; Guangzhou Medical University; Guangzhou Medical
   University
RP Wu, FC (corresponding author), Liwan Dist, Guangzhou 510370, Peoples R China.; Zhang, XY (corresponding author), 16 Lincui Rd,Chaoyang Dist, Beijing 100101, Peoples R China.
EM 13580380071@163.com; zhangxy9@gmail.com
RI Zhang, Xiangyang/ABC-7380-2022; Wu, Fengchun/JBR-9982-2023
OI Zhang, Xiangyang/0000-0003-3326-382X; Wu, Fengchun/0000-0003-2817-2341
FU National Natural Science Foundation of China [82301688]; Science and
   Technology Program of Guangzhou [202206060005, 202201010093,
   2023A03J0856, 2023A03J0839]; Guangdong Basic and Applied Basic Research
   Foundation Outstanding Youth Project [2021B1515020064]; Medical Science
   and Technology Research Foundation of Guangdong [A2023224]; Health
   Science and Technology Program of Guangzhou [20231A010036]; Natural
   Science Foundation Program of Guangdong [2023A1515011383]
FX This study was supported by the the National Natural Science Foundation
   of China (82301688) , Science and Technology Program of Guangzhou
   (202206060005, 202201010093, 2023A03J0856, 2023A03J0839) , and Guangdong
   Basic and Applied Basic Research Foundation Outstanding Youth Project
   (2021B1515020064) , Medical Science and Technology Research Foundation
   of Guangdong (A2023224) , the Health Science and Technology Program of
   Guangzhou (20231A010036) , and the Natural Science Foundation Program of
   Guangdong (2023A1515011383) . The funder had no role in the design and
   conduct of the study; collection, management, analysis, and
   inter-pretation of the data; preparation, review, or approval of the
   manu-script; and decision to submit the manuscript for publication.
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NR 72
TC 4
Z9 4
U1 3
U2 12
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0920-9964
EI 1573-2509
J9 SCHIZOPHR RES
JI Schizophr. Res.
PD FEB
PY 2024
VL 264
BP 81
EP 86
DI 10.1016/j.schres.2023.12.004
EA DEC 2023
PG 6
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA FF1Y4
UT WOS:001144268800001
PM 38113675
DA 2025-06-11
ER

PT J
AU Serwotka-Suszczak, AM
   Marcinkowska, KA
   Smieszek, A
   Michalak, IM
   Grzebyk, M
   Wisniewski, M
   Marycz, KM
AF Serwotka-Suszczak, Anna M.
   Marcinkowska, Klaudia A.
   Smieszek, Agnieszka
   Michalak, Izabela M.
   Grzebyk, Michal
   Wisniewski, Maciej
   Marycz, Krzysztof M.
TI The Haematococcus pluvialis extract enriched by bioaccumulation
   process with Mg(II) ions improves insulin resistance in equine
   adipose-derived stromal cells (EqASCs)
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Article
DE Equine ASCs; Haematococcus pluvialis; Insulin resistance
ID OXIDATIVE STRESS; SENSITIVITY; OBESITY; MAGNESIUM; WEIGHT; HORSES;
   PONIES; BLOOD; ALGAE
AB Insulin resistance (IR) is one of the characteristic features of equine metabolic syndrome (EMS). Presently, the only therapies of choice are caloric restrictions combined with mineral supplementation, which might improve insulin sensitivity. In this study we investigated the effect of Haematococcus pluvialis algae water extract enriched in bioaccumulation process in magnesium ions (Hp_Mg(II)) on equine adipose derived mesenchymal stromal stem cells, in which insulin resistance was induced by palmitic acid (IR-EqASCs). For this purpose, chemical characterization of H. pluvialis was performed with special emphasis on the analysis of minerals composition, total phenolic and carotenoids contents, as well as scavenging activity. To examine the influence of H. pluvialis extract on IR-EqASCs, various methods of molecular biology and microscopic observations (i.e., immunofluorescence staining, SEM, gene expression by RT-qPCR, proliferative and metabolic cells activity analysis) were applied to investigate in vitro viability, oxidative stress markers and apoptosis-related factor accumulation, along with insulin resistance-related genes expression. Obtained results show, that Hp_Mg(II) significantly improves proliferative and metabolic activity of IR-EqASCs, shortens their population doubling time, improves their clonogenic potential and reduces expression of apoptosis related genes. Moreover, anti-oxidative effect of extract was presented.
C1 [Serwotka-Suszczak, Anna M.; Marcinkowska, Klaudia A.; Smieszek, Agnieszka; Marycz, Krzysztof M.] Wroclaw Univ Environm & Life Sci, Dept Expt Biol, Norwida 27B, PL-50375 Wroclaw, Poland.
   [Michalak, Izabela M.] Wroclaw Univ Sci & Technol, Fac Chem, Dept Adv Mat Technol, Smoluchowskiego 25, PL-50372 Wroclaw, Poland.
   [Grzebyk, Michal; Wisniewski, Maciej] AlgaeLabs Fdn, Dunska 9, PL-54427 Wroclaw, Poland.
C3 Wroclaw University of Environmental & Life Sciences; Wroclaw University
   of Science & Technology
RP Marycz, KM (corresponding author), Wroclaw Univ Environm & Life Sci, Dept Expt Biol, Norwida 27B, PL-50375 Wroclaw, Poland.
EM anna.serwotka-suszczak@upwr.edu.pl; klaudia.marcinkowska@upwr.edu.pl;
   agnieszka.smieszek@upwr.edu.pl; izabela.michalak@pwr.edu.pl;
   m.grzebyk@algaelabs.pl; m.wisniewski@algaelabs.pl;
   krzysztof.marycz@upwr.edu.pl
RI Serwotka-Suszczak, Anna/L-7188-2019; Michalak, Izabela/P-3770-2015;
   Smieszek, Agnieszka/A-4887-2017
OI Grzebyk, Michal/0000-0002-7642-741X; Michalak,
   Izabela/0000-0001-8084-9642; Smieszek, Agnieszka/0000-0002-7314-9821
FU National Science Centre in Poland [2015/18/E/NZ9/00607]
FX This project is financed in the framework of grant entitled "The effect
   of bioactive algae enriched by biosorption on the certain minerals such
   as Cr(III), Mg(II) and Mn(II) on the status of glucose in the course of
   metabolic syndrome horses. Evaluation in vitro and in vivo"
   (2015/18/E/NZ9/00607) attributed by The National Science Centre in
   Poland.
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NR 51
TC 5
Z9 5
U1 1
U2 15
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD AUG
PY 2019
VL 116
AR 108972
DI 10.1016/j.biopha.2019.108972
PG 12
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA ID3QV
UT WOS:000471592900072
PM 31103825
OA gold
DA 2025-06-11
ER

PT J
AU Vrabcova, M
   Mikuska, L
   Zeman, M
   Mravec, B
AF Vrabcova, Michaela
   Mikuska, Livia
   Zeman, M.
   Mravec, B.
TI EXAGGERATED ACTIVITY OF HPA AXIS IN OBESE RATS FED NORMOCALORIC LIQUID
   NUTRITION
SO ACTA BIOLOGICA HUNGARICA
LA English
DT Article
DE Corticosterone; Fresubin; liquid nutrition; obesity; rats
ID HIGH-FAT DIET; CHRONIC STRESS; METABOLIC SYNDROME; RESISTANT RATS;
   ZUCKER RATS; BODY-WEIGHT; GLUCOCORTICOIDS; TESTOSTERONE; FEEDBACK;
   TISSUE
AB Experimental and clinical studies have shown alterations in activity of systems responsible for neuroendocrine stress response in obese individuals. Therefore we investigated the effect of palatable normocaloric liquid nutrition (Fresubin) on alterations in activity of the hypothalamic-pituitary-adrenal (HPA) axis in male Wistar rats of different developmental stages. Control rats (CON) received standard pellet chow all the time from weaning (21st day of age) to 150 days. Fresubin was administered throughout the experiment (LN), only in juvenility (from 21st to 90th day of age; LNJ) or only in adulthood (from 90th to 150th day of age; LNA). Body weight and energy intake were periodically monitored. Adrenal gland and fat tissue weight and plasma corticosterone levels (CORT) was determined after sacrification. Fresubin intake induced obesity in LN and LNA rats. In LN and LNA rats were observed elevated serum CORT levels, but only in LN rats with significant twofold increase compared to LNJ rats. However, the weight of adrenal glands did not differ between LN, LNJ and LNA experimental groups. Based on our results, we suggest, that obesity induced by Fresubin in LN and LNA rats is accompanied by increased HPA activity represented by elevated plasma CORT levels in these rats.
C1 [Vrabcova, Michaela] Comenius Univ, Inst Histol & Embryol, Fac Med, Bratislava 81108, Slovakia.
   [Mikuska, Livia; Mravec, B.] Slovak Acad Sci, Inst Expt Endocrinol, Bratislava 84215, Slovakia.
   [Zeman, M.] Comenius Univ, Fac Nat Sci, Dept Anim Physiol & Ethol, Bratislava 84215, Slovakia.
   [Mravec, B.] Comenius Univ, Inst Physiol, Fac Med, Bratislava 81108, Slovakia.
C3 Comenius University Bratislava; Slovak Academy of Sciences; Institute of
   Experimental Endocrinology, SAS; Comenius University Bratislava;
   Comenius University Bratislava; Slovak Academy of Sciences
RP Mravec, B (corresponding author), Slovak Acad Sci, Inst Expt Endocrinol, Vlarska 3, Bratislava 84215, Slovakia.
EM boris.mravec@fmed.uniba.sk
RI Zeman, Michal/L-2392-2019
OI Mravec, Boris/0000-0002-3177-6819; Zeman, Michal/0000-0002-2712-6805
FU Comenius University [UK/119/2013]; European Regional Development Fund
   Research and Development Grant [ITMS 26240120015]
FX This work was supported by a grant of Comenius University (UK/119/2013)
   and a European Regional Development Fund Research and Development Grant
   (ITMS 26240120015).
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NR 26
TC 1
Z9 1
U1 0
U2 2
PU AKADEMIAI KIADO RT
PI BUDAPEST
PA PRIELLE K U 19, PO BOX 245,, H-1117 BUDAPEST, HUNGARY
SN 0236-5383
EI 1588-256X
J9 ACTA BIOL HUNG
JI Acta Biol. Hung.
PD SEP
PY 2014
VL 65
IS 3
BP 285
EP 293
DI 10.1556/ABiol.65.2014.3.5
PG 9
WC Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics
GA CA1DA
UT WOS:000348652000005
PM 25194732
DA 2025-06-11
ER

PT J
AU Rocha, M
   Apostolova, N
   Herance, JR
   Rovira-Llopis, S
   Hernandez-Mijares, A
   Victor, VM
AF Rocha, Milagros
   Apostolova, Nadezda
   Herance, Jose Raul
   Rovira-Llopis, Susana
   Hernandez-Mijares, Antonio
   Victor, Victor M.
TI Perspectives and Potential Applications of Mitochondria-Targeted
   Antioxidants in Cardiometabolic Diseases and Type 2 Diabetes
SO MEDICINAL RESEARCH REVIEWS
LA English
DT Review
DE cardiometabolic disease; diabetes; insulin resistance; mitochondria;
   oxidative stress
ID INDUCED INSULIN-RESISTANCE; ACTIVATED PROTEIN-KINASE; HIGH-FAT DIET;
   PHOSPHATIDYLINOSITOL 3-KINASE ACTIVITY; RECEPTOR-GAMMA COACTIVATOR-1;
   HUMAN UNCOUPLING PROTEIN-3; OXYGEN SPECIES PRODUCTION; OVARY-SYNDROME
   PATIENTS; HUMAN SKELETAL-MUSCLE; OXIDATIVE STRESS
AB There is abundant evidence to suggest that mitochondrial dysfunction is a main cause of insulin resistance and related cardiometabolic comorbidities. On the other hand, insulin resistance is one of the main characteristics of type 2 diabetes, obesity, and metabolic syndrome. Lipid and glucose metabolism require mitochondria to generate energy, and when O-2 consumption is low due to inefficient nutrient oxidation, there is an increase in reactive oxygen species, which can impair different types of molecules, including DNA, lipids, proteins, and carbohydrates, thereby inducing proinflammatory processes. Factors which contribute to mitochondrial dysfunction, such as mitochondrial biogenesis and genetics, can also lead to insulin resistance in different insulin-target tissues, and its association with mitochondrial dysfunction can culminate in the development of cardiovascular diseases. In this context, therapies that improve mitochondrial function may also improve insulin resistance. This review explains mechanisms of mitochondrial function related to the pathological effects of insulin resistance in different tissues. The pathogenesis of cardiometabolic diseases will be explained from a mitochondrial perspective and the potential beneficial effects of mitochondria-targeted antioxidants as a therapy for modulating mitochondrial function in cardiometabolic diseases, especially diabetes, will also be considered.
C1 [Rocha, Milagros; Rovira-Llopis, Susana; Hernandez-Mijares, Antonio; Victor, Victor M.] Fdn Invest Sanitaria & Biomed Comunidad Valencian, Valencia, Spain.
   [Rocha, Milagros; Rovira-Llopis, Susana; Hernandez-Mijares, Antonio; Victor, Victor M.] Univ Hosp Doctor Peset, Serv Endocrinol, Valencia, Spain.
   [Rocha, Milagros; Hernandez-Mijares, Antonio; Victor, Victor M.] INCLIVA Fdn, Valencia, Spain.
   [Apostolova, Nadezda; Victor, Victor M.] Univ Valencia, Dept Pharmacol, Valencia, Spain.
   [Apostolova, Nadezda; Victor, Victor M.] Univ Valencia, CIBER Hepat & Digest Dis, CIBER Res Grp CB06 04 0071, Valencia, Spain.
   [Herance, Jose Raul] Parc Recerca Biomed Barcelona PRBB, CRC Ctr Imatge Mol CRC CIM, Barcelona, Spain.
   [Hernandez-Mijares, Antonio] Univ Valencia, Dept Med, Valencia, Spain.
   [Victor, Victor M.] Univ Valencia, Dept Physiol, Valencia, Spain.
C3 University of Valencia; University of Valencia; CIBER - Centro de
   Investigacion Biomedica en Red; CIBEREHD; Pompeu Fabra University;
   Barcelona Biomedical Research Park; University of Valencia; University
   of Valencia
RP Victor, VM (corresponding author), Fdn Invest Sanitaria & Biomed Comunidad Valencian, Valencia, Spain.
EM victor.victor@uv.es
RI victor, victor/Q-4843-2019; Camacho, José/Q-3416-2016; Rocha,
   Milagros/I-4987-2015; Hernandez Mijares, Antonio/D-3411-2011;
   Apostolova, Nadezda/K-5930-2017; Rovira-Llopis, Susana/AAX-8666-2021
OI Rocha, Milagros/0000-0003-2923-6546; Hernandez Mijares,
   Antonio/0000-0003-4099-1905; Herance, Jose Raul/0000-0001-7178-3290;
   VICTOR, VICTOR/0000-0002-3027-3945; Apostolova,
   Nadezda/0000-0002-4487-2471; Rovira-Llopis, Susana/0000-0002-8476-5128
FU European Regional Development Fund (ERDF);  [PI10/1195];  [PI 12/1984]; 
   [CIBERehd CB06/04/0071];  [PROMETEO 2010/060];  [ACOMP/2012/042]; 
   [ACOMP/2012/045];  [ACOMP2013/061]
FX Contract grant sponsor: PI10/1195; Contract grant sponsor: PI 12/1984;
   Contract grant sponsor: CIBERehd CB06/04/0071; Contract grant sponsor:
   PROMETEO 2010/060; Contract grant sponsor: ACOMP/2012/042; Contract
   grant sponsor: ACOMP/2012/045; Contract grant sponsor: ACOMP2013/061;
   Contract grant sponsor: European Regional Development Fund (ERDF).
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NR 182
TC 50
Z9 53
U1 0
U2 39
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0198-6325
EI 1098-1128
J9 MED RES REV
JI Med. Res. Rev.
PD JAN
PY 2014
VL 34
IS 1
BP 160
EP 189
DI 10.1002/med.21285
PG 30
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 260MG
UT WOS:000327598400006
PM 23650093
OA Green Published
DA 2025-06-11
ER

PT J
AU Alzamendi, A
   Giovambattista, A
   García, ME
   Rebolledo, OR
   Gagliardino, JJ
   Spinedi, E
AF Alzamendi, Ana
   Giovambattista, Andres
   Garcia, Maria E.
   Rebolledo, Oscar R.
   Gagliardino, Juan J.
   Spinedi, Eduardo
TI Effect of Pioglitazone on the Fructose-Induced Abdominal Adipose Tissue
   Dysfunction
SO PPAR RESEARCH
LA English
DT Article
ID INDUCED INSULIN-RESISTANCE; METABOLIC-SYNDROME; OXIDATIVE STRESS;
   SWEETENED BEVERAGES; GENE-EXPRESSION; RICH DIET; GLUCOSE; IMPROVES;
   RATS; CONSUMPTION
AB Aim. To test the potential role of PPAR gamma in the endocrine abdominal tissue dysfunction induced by feeding normal rats with a fructose rich diet (FRD) during three weeks. Methodology. Adult normal male rats received a standard commercial diet (CD) or FRD, (10% in drinking water) without or with pioglitazone (PIO) (i.p. 0.25 mg/Kg BW/day; CD-PIO and FRD-PIO). Thereafter, we measured circulating metabolic, endocrine, and oxidative stress (OS) markers, abdominal adipose tissue (AAT) mass, leptin (LEP) and plasminogen activator inhibitor-1 (PAI-1) tissue content/expression, and leptin release by isolated adipocytes incubated with different concentrations of insulin. Results. Plasma glucose, insulin, triglyceride, TBARS, LEP, and PAI-1 levels were higher in FRD rats; PIO coadministration fully prevented all these increments. AAT adipocytes from FRD rats were larger, secreted a higher amount of LEP, and displayed decreased sensitivity to insulin stimulation; these effects were significantly ameliorated by PIO. Whereas AAT LEP and PAI-1 (mRNA) concentrations increased significantly in FRD rats, those of insulin-receptor-substrate-(IRS-) 1 and IRS-2 were reduced. PIO coadministration prevented FRD effects on LEP, PAI-1, and IRS-2 (fully) and IRS-1 (partially) mRNAs in AAT. Conclusion. PPAR gamma would play a relevant role in the development of the FRD-induced metabolic-endocrine dysfunction.
C1 [Alzamendi, Ana; Giovambattista, Andres; Spinedi, Eduardo] CICPBA, Neuroendocrine Unit IMBICE, RA-1900 La Plata, Argentina.
   [Alzamendi, Ana; Giovambattista, Andres; Garcia, Maria E.; Rebolledo, Oscar R.; Gagliardino, Juan J.; Spinedi, Eduardo] Consejo Nacl Invest Cient & Tecn, RA-1900 La Plata, Argentina.
   [Garcia, Maria E.; Rebolledo, Oscar R.; Gagliardino, Juan J.] UNLP, CENEXA, RA-1900 La Plata, Argentina.
   [Garcia, Maria E.; Rebolledo, Oscar R.; Gagliardino, Juan J.] PAHO WHO Collaborating Ctr, RA-1900 La Plata, Argentina.
C3 Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET);
   National University of La Plata; Consejo Nacional de Investigaciones
   Cientificas y Tecnicas (CONICET)
RP Spinedi, E (corresponding author), CICPBA, Neuroendocrine Unit IMBICE, POB 403, RA-1900 La Plata, Argentina.
EM espinedi@gmail.com
RI Spinedi, Eduardo/F-2455-2016
OI Alzamendi, Ana/0000-0003-4126-1103
FU CONICET [PIPs 2009-0704, PIPs 2009-5020]; Fondation pour la Recherche en
   Endocrinologie, Diabetologie et Metabolisme (FPREDM); FONCyT [PICT
   2001-1051]
FX This study was supported by grants from CONICET (PIPs 2009-0704 to E.
   Spinedi, and -5020 to J. J. Gagliardino), Fondation pour la Recherche en
   Endocrinologie, Diabetologie et Metabolisme (FPREDM 2011/2012 to E.
   Spinedi), and FONCyT (PICT 2001-1051). A. Giovambattista, J. J.
   Gagliardino, and E. Spinedi are members of the Research Career of
   CONICET (Argentina). The authors gratefully thank D. Castrogiovanni and
   A. Diaz for their excellent technical assistance and A. Di Maggio and S.
   H. Rogers for paper edition and correction, respectively. This work was
   written in the memory of Professor Dr. Rolf C. Gaillard (Division of
   Endocrinology, Diabetology, and Metabolism, University Hospital, CHUV,
   Lausanne, Switzerland), a coauthor deceased on November 17, 2011.
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NR 50
TC 19
Z9 19
U1 0
U2 1
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1687-4757
EI 1687-4765
J9 PPAR RES
JI PPAR Res.
PY 2012
VL 2012
AR 259093
DI 10.1155/2012/259093
PG 9
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 020AE
UT WOS:000309779900001
PM 23091482
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Kaser, S
   Ebenbichler, CF
   Tilg, H
AF Kaser, S.
   Ebenbichler, C. F.
   Tilg, H.
TI Pharmacological and non-pharmacological treatment of non-alcoholic fatty
   liver disease
SO INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
LA English
DT Review
ID PROLIFERATOR-ACTIVATED-RECEPTOR; ENDOPLASMIC-RETICULUM STRESS; MODERATE
   WEIGHT-REDUCTION; GASTRIC BYPASS IMPROVES; ACETYL-COA CARBOXYLASE;
   NECROSIS-FACTOR-ALPHA; INSULIN-RESISTANCE; HEPATIC STEATOSIS;
   PROTEIN-KINASE; LIFE-STYLE
AB Non-alcoholic fatty liver disease (NAFLD) comprises a disease spectrum ranging from simple steatosis and steatohepatitis to cirrhosis. Based on its strongest risk factors namely visceral obesity and insulin resistance, NAFLD is thought to be the hepatic manifestation of the metabolic syndrome and is considered to be the most common liver disorder in Western countries. Pathophysiological mechanisms include an enlarged pool of fatty acids, subclinical inflammation, oxidative stress and imbalances of various adipocytokines such as adiponectin. Accordingly, targets for therapeutic interventions are miscellaneous: amelioration of obesity by pharmacological, surgical or lifestyle intervention has been evaluated with success in numerous, but not all studies. Some efficacy was reported for metformin and short-term glitazone treatment. In a large recently reported trial, vitamin E supplementation improved biochemical and histological markers in subjects with nonalcoholic steatohepatitis. Blockade of the endocannabinoid system has been proposed to be a promising target in NAFLD; however, very recently the cannabinoid receptor blocker rimonabant has been withdrawn because of central nervous system toxicity. Cytoprotective therapies and statins have been mainly ineffective in NAFLD. New but so far insufficiently studied therapeutic approaches include inhibitors of the renin-angiotensin system as well as incretin mimetics respectively.
C1 [Kaser, S.; Ebenbichler, C. F.] Med Univ Innsbruck, Fac Med 1, A-6020 Innsbruck, Austria.
   [Tilg, H.] Med Univ Innsbruck, Div Gastroenterol & Hepatol, Christian Doppler Res Lab Gut Inflammat, A-6020 Innsbruck, Austria.
C3 Medical University of Innsbruck; Medical University of Innsbruck
RP Ebenbichler, CF (corresponding author), Med Univ Innsbruck, Fac Med 1, Anichstr 35, A-6020 Innsbruck, Austria.
EM christoph.ebenbichler@i-med.ac.at
RI Kaser, Susanne/JEO-6334-2023; Tilg, Herbert/AEO-9569-2022
OI Ebenbichler, Christoph/0000-0001-5025-7929; Kaser,
   Susanne/0000-0003-2524-5218
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NR 174
TC 33
Z9 36
U1 0
U2 10
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1368-5031
EI 1742-1241
J9 INT J CLIN PRACT
JI Int. J. Clin. Pract.
PD JUN
PY 2010
VL 64
IS 7
BP 968
EP 983
DI 10.1111/j.1742-1241.2009.02327.x
PG 16
WC Medicine, General & Internal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Pharmacology & Pharmacy
GA 597UX
UT WOS:000277788700020
PM 20584230
OA gold
DA 2025-06-11
ER

PT J
AU Czyz-Szypenbejl, K
   Medrzycka-Dabrowska, W
AF Czyz-Szypenbejl, Katarzyna
   Medrzycka-Dabrowska, Wioletta
TI The Impact of Night Work on the Sleep and Health of Medical Staff-A
   Review of the Latest Scientific Reports
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Review
DE nurse; healthcare workers; night work; sleep; sleep disorders; health
ID QUALITY-OF-LIFE; SHIFT WORK; CARE EMPLOYEES; BLOOD-PRESSURE; NURSES;
   ASSOCIATIONS; DISORDERS; DISEASE; STRESS
AB Introduction: Employees working in shifts are exposed to many threats affecting their health, quality of life and safety at work. Those who perform their work only at night are particularly vulnerable. The purpose of the review is to identify risks to the health, quality of life and sleep of shift health workers. Method: A systematic review (SR) was used in the analysis. Electronic databases were searched. The search was limited to the latest studies published in the last five years: 2019-2023. Results: Finally, 36 articles were included in the review. Most authors have shown a link between sleep disturbance or its quality and shift work/night work. Moreover, a three-shift schedule was the most significant factor for poorer subjective sleep quality when compared to other work schedules. Furthermore, many authors have shown a link between shift/night work and health problems, which include cardiometabolic risk, glucose intolerance, breast cancer and immune vulnerability. Conclusions: The research results clearly show a significant impact of night work on the increased risk of sleep disorders and health disturbance. Healthcare workers should be aware of the risks associated with night work in order to take measures preventing sleep/health problems. Shift/night workers should have the opportunity to be screened for disorders linked with their work.
C1 [Czyz-Szypenbejl, Katarzyna; Medrzycka-Dabrowska, Wioletta] Med Univ Gdansk, Fac Hlth Sci, Dept Anaesthesiol Nursing & Inte & Intens Care, PL-80211 Gdansk, Poland.
C3 Fahrenheit Universities; Medical University Gdansk
RP Medrzycka-Dabrowska, W (corresponding author), Med Univ Gdansk, Fac Hlth Sci, Dept Anaesthesiol Nursing & Inte & Intens Care, PL-80211 Gdansk, Poland.
EM katarzyna.czyz-szypenbejl@gumed.edu.pl; wioletta.medrzycka@gumed.edu.pl
RI MEDRZYCKA-DABROWSKA, WIOLETTA ANNA/AAH-3759-2020
OI MEDRZYCKA-DABROWSKA, WIOLETTA ANNA/0000-0001-8377-4893
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NR 88
TC 4
Z9 4
U1 5
U2 10
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD AUG
PY 2024
VL 13
IS 15
AR 4505
DI 10.3390/jcm13154505
PG 14
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA C1G7I
UT WOS:001286921800001
PM 39124771
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU de la Cuesta-zuluaga, J
   Huus, KE
   Youngblut, ND
   Escobar, JS
   Ley, RE
AF de la Cuesta-zuluaga, Jacobo
   Huus, Kelsey E.
   Youngblut, Nicholas D.
   Escobar, Juan S.
   Ley, Ruth E.
TI Obesity is the main driver of altered gut microbiome functions in the
   metabolically unhealthy
SO GUT MICROBES
LA English
DT Article
DE Obesity; cardiometabolic disease; gut microbiome; fecal metagenomes;
   functional potential; microbiome diversity
ID TRIMETHYLAMINE N-OXIDE; CARDIOMETABOLIC RISK; R-PACKAGE; ASSOCIATION;
   WEIGHT; METAGENOME; OVERWEIGHT; EXPRESSION; PHENOTYPES; PHYSIOLOGY
AB Obesity (OB) and cardiometabolic disease are major public health issues linked to changes in the gut microbiome. OB and poor cardiometabolic health status (CHS) are often comorbid, which hinders efforts to identify components of the microbiome uniquely linked to either one. Here, we used a deeply phenotyped cohort of 408 adults from Colombia, including subjects with OB, unhealthy CHS, or both, to validate previously reported features of gut microbiome function and diversity independently correlated with OB or CHS using fecal metagenomes. OB was defined by body mass index, waist circumference, and body fat; CHS as healthy or unhealthy according to blood biochemistry and anthropometric data. We found that OB, more so than metabolic status, drove associations with gut microbiome structure and functions. The microbiome of obese individuals with and without co-existing unhealthy CHS was characterized by reduced metagenomic diversity, reduced fermentative potential and elevated capacity to respond to oxidative stress and produce bacterial antigens. Disease-linked features were correlated with increased host blood pressure and inflammatory markers, and were mainly contributed by members of the family Enterobacteriaceae. Our results link OB with a microbiome able to tolerate an inflammatory and oxygenated gut state, and suggest that OB is the main driver of microbiome functional differences when poor CHS is a comorbidity.
C1 [de la Cuesta-zuluaga, Jacobo; Huus, Kelsey E.; Youngblut, Nicholas D.; Ley, Ruth E.] Max Planck Inst Biol Tubingen, Dept Microbiome Sci, Tubingen, Germany.
   [Escobar, Juan S.] Vidarium Nutr Hlth & Wellness Res Ctr, Grp Empresarial Nutresa, Medellin, Colombia.
   [Ley, Ruth E.] Univ Tubingen, Cluster Excellence EXC 2124 Controlling Microbes F, Tubingen, Germany.
   [de la Cuesta-zuluaga, Jacobo] Interfac Inst Microbiol & Infect Med, D-72076 Tubingen, Germany.
C3 Eberhard Karls University of Tubingen
RP Ley, RE (corresponding author), Max Planck Inst Biol Tubingen, Dept Microbiome Sci, Tubingen, Germany.
EM rley@tuebingen.mpg.de
RI Huus, Kelsey/LOU-0260-2024; Ley, Ruth/M-8542-2014; Escobar, Juan
   S/F-7234-2013
OI Huus, Kelsey Elizabeth/0000-0002-7580-1924; Ley,
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   Cuesta-Zuluaga, Juan Jacobo/0000-0002-7369-992X; Escobar, Juan
   S/0000-0001-7304-917X
FU Max Planck Society; Vidarium-Nutrition, Health and Wellness Research
   Center
FX This work was supported by the Max Planck Society (J.d.l.C- Z., K.H.,
   N.D.Y., R.E.L.) and Vidarium-Nutrition, Health and Wellness Research
   Center (J.S.E.).
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NR 83
TC 5
Z9 5
U1 3
U2 20
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1949-0976
EI 1949-0984
J9 GUT MICROBES
JI Gut Microbes
PD DEC 18
PY 2023
VL 15
IS 2
AR 2246634
DI 10.1080/19490976.2023.2246634
PG 22
WC Gastroenterology & Hepatology; Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Microbiology
GA Q9QE2
UT WOS:001060781800001
PM 37680093
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Pinos, H
   Carrillo, B
   Merchán, A
   Biosca-Brull, J
   Pérez-Fernandez, C
   Colomina, MT
   Sánchez-Santed, F
   Martín-Sánchez, F
   Collado, P
   Arias, JL
   Conejo, NM
AF Pinos, Helena
   Carrillo, Beatriz
   Merchan, Ana
   Biosca-Brull, Judit
   Perez-Fernandez, Cristian
   Colomina, Maria Teresa
   Sanchez-Santed, Fernando
   Martin-Sanchez, Fernando
   Collado, Paloma
   Arias, Jorge L.
   Conejo, Nelida M.
TI Relationship between Prenatal or Postnatal Exposure to Pesticides and
   Obesity: A Systematic Review
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Review
DE obesity; pesticides; organophosphate; organochlorine; chlorpyrifos;
   carbamates; pyrethroids; neonicotinoids
ID PERSISTENT ORGANIC POLLUTANTS; RAPID WEIGHT-GAIN; HIGH-FAT DIET;
   DEVELOPMENTAL EXPOSURE; OXIDATIVE STRESS; ENVIRONMENTAL CONTAMINANTS;
   DISRUPTING CHEMICALS; CARDIOMETABOLIC RISK; SEX-DIFFERENCES;
   ADIPOSE-TISSUE
AB In recent years, the worldwide prevalence of overweight and obesity among adults and children has dramatically increased. The conventional model regarding the onset of obesity is based on an imbalance between energy intake and expenditure. However, other possible environmental factors involved, such as the exposure to chemicals like pesticides, cannot be discarded. These compounds could act as endocrine-disrupting chemicals (EDC) that may interfere with hormone activity related to several mechanisms involved in body weight control. The main objective of this study was to systematically review the data provided in the scientific literature for a possible association between prenatal and postnatal exposure to pesticides and obesity in offspring. A total of 25 human and 9 animal studies were analyzed. The prenatal, perinatal, and postnatal exposure to organophosphate, organochlorine, pyrethroid, neonicotinoid, and carbamate, as well as a combined pesticide exposure was reviewed. This systematic review reveals that the effects of pesticide exposure on body weight are mostly inconclusive, finding conflicting results in both humans and experimental animals. The outcomes reviewed are dependent on many factors, including dosage and route of administration, species, sex, and treatment duration. More research is needed to effectively evaluate the impact of the combined effects of different pesticides on human health.
C1 [Pinos, Helena; Carrillo, Beatriz; Collado, Paloma] Natl Distance Educ Univ UNED, Fac Psychol, Dept Psychobiol, Madrid 28040, Spain.
   [Pinos, Helena; Carrillo, Beatriz; Martin-Sanchez, Fernando; Collado, Paloma] Joint Res Inst UNED Inst Salud Carlos III IMIENS, Madrid 28029, Spain.
   [Merchan, Ana; Perez-Fernandez, Cristian; Sanchez-Santed, Fernando] Almeria Univ, Dept Psychol, Almeria 04120, Spain.
   [Merchan, Ana; Perez-Fernandez, Cristian; Sanchez-Santed, Fernando] Almeria Univ, Hlth Res Ctr CEINSA, Almeria 04120, Spain.
   [Biosca-Brull, Judit; Colomina, Maria Teresa] Univ Rovira & Virgili, Res Neurobehav & Hlth NEUROLAB, Tarragona 43007, Spain.
   [Biosca-Brull, Judit; Colomina, Maria Teresa] Univ Rovira & Virgili, Dept Psychol, Tarragona 43007, Spain.
   [Biosca-Brull, Judit; Colomina, Maria Teresa] Univ Rovira & Virgili, Res Ctr Behav Assessment CRAMC, Tarragona 43007, Spain.
   [Martin-Sanchez, Fernando] Inst Hlth Carlos III, Univ Inst Res UNED Inst Hlth Carlos III IMIENS, Natl Sch Publ Hlth, Madrid 28029, Spain.
   [Arias, Jorge L.; Conejo, Nelida M.] Univ Oviedo, Inst Neurociencias Principado Asturias INEUROPA, Dept Psychol, Lab Neurosci, Oviedo 33003, Spain.
   [Arias, Jorge L.; Conejo, Nelida M.] Inst Invest Sanit Principado Asturias ISPA, Oviedo 33006, Spain.
C3 Universidad Nacional de Educacion a Distancia (UNED); Universidad de
   Almeria; Universidad de Almeria; Universitat Rovira i Virgili;
   Universitat Rovira i Virgili; Universitat Rovira i Virgili; University
   of Oviedo
RP Pinos, H (corresponding author), Natl Distance Educ Univ UNED, Fac Psychol, Dept Psychobiol, Madrid 28040, Spain.; Pinos, H (corresponding author), Joint Res Inst UNED Inst Salud Carlos III IMIENS, Madrid 28029, Spain.; Conejo, NM (corresponding author), Univ Oviedo, Inst Neurociencias Principado Asturias INEUROPA, Dept Psychol, Lab Neurosci, Oviedo 33003, Spain.; Conejo, NM (corresponding author), Inst Invest Sanit Principado Asturias ISPA, Oviedo 33006, Spain.
EM hpinos@psi.uned.es; bcarrillo@psi.uned.es; anamercar@gmail.com;
   judit.biosca@urv.cat; cpf603@ual.es; mariateresa.colomina@urv.cat;
   fsanchez@ual.es; fmartin@isciii.es; pcollado@psi.uned.es;
   jarias@uniovi.es; conejonelida@uniovi.es
RI CONEJO, NÉLIDA/N-3693-2014; Sanchez-Santed, Fernando/A-3855-2008; Pinos,
   Helena/AAA-8709-2020; Carrillo, Ana/S-3566-2019; Collado,
   Paloma/M-6834-2015; Pinos, Helena/M-7376-2015; Perez-Fernandez,
   Cristian/ABG-6514-2021; Carrillo, Beatriz/M-7440-2015; Colomina, Maria
   Teresa/A-5919-2011
OI Biosca Brull, Judit/0000-0001-7386-8271; Collado,
   Paloma/0000-0002-2925-6806; Pinos, Helena/0000-0002-5323-6602;
   Perez-Fernandez, Cristian/0000-0001-6675-2086; CONEJO, NELIDA
   MARIA/0000-0003-4749-5453; Carrillo, Beatriz/0000-0002-7393-3675;
   Colomina, Maria Teresa/0000-0002-5619-4874; Merchan Carrillo, Ana
   Maria/0000-0001-6832-9281; /0000-0003-0983-8654
FU Spanish Government (Ministerio de Economia y Competitividad); Instituto
   Mixto de Investigacion-Escuela Nacional de Sanidad (IMIENS); Fondo
   Europeo de Desarrollo Regional (MINECO-FEDER) [PSI2017-90806-REDT,
   PSI2017-83038-P, PSI2017-83893-R, PSI2017-86396-P,
   PSI2017-86847-C2-2-R]; IMIENS [PIC-IMIENS-2018-003]
FX This study was supported by grants from the Spanish Government
   (Ministerio de Economia y Competitividad and Instituto Mixto de
   Investigacion-Escuela Nacional de Sanidad (IMIENS)) and the Fondo
   Europeo de Desarrollo Regional (MINECO-FEDER) Grant numbers:
   PSI2017-90806-REDT, PSI2017-83038-P, PSI2017-83893-R, PSI2017-86396-P,
   PSI2017-86847-C2-2-R MINECO-FEDER, and IMIENS: PIC-IMIENS-2018-003.
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NR 121
TC 22
Z9 22
U1 8
U2 72
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD JUL
PY 2021
VL 18
IS 13
AR 7170
DI 10.3390/ijerph18137170
PG 24
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA TH2UF
UT WOS:000671949100001
PM 34281107
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Gertsch, J
AF Gertsch, Jurg
TI Cannabimimetic phytochemicals in the diet - an evolutionary link to food
   selection and metabolic stress adaptation?
SO BRITISH JOURNAL OF PHARMACOLOGY
LA English
DT Review
ID CANNABINOID CB2 RECEPTOR; ACID AMIDE HYDROLASE; POLYUNSATURATED
   FATTY-ACIDS; GAMMA PPAR-GAMMA; ENDOCANNABINOID SYSTEM;
   BETA-CARYOPHYLLENE; ARACHIDONIC-ACID; NATURAL-PRODUCTS; CONCISE GUIDE;
   INSULIN-RESISTANCE
AB The endocannabinoid system (ECS) is a major lipid signalling network that plays important pro-homeostatic (allostatic) roles not only in the nervous system but also in peripheral organs. There is increasing evidence that there is a dietary component in the modulation of the ECS. Cannabinoid receptors in hominids co-evolved with diet, and the ECS constitutes a feedback loop for food selection and energy metabolism. Here, it is postulated that the mismatch of ancient lipid genes of hunter-gatherers and pastoralists with the high-carbohydrate diet introduced by agriculture could be compensated for via dietary modulation of the ECS. In addition to the fatty acid precursors of endocannabinoids, the potential role of dietary cannabimimetic phytochemicals in agriculturist nutrition is discussed. Dietary secondary metabolites from vegetables and spices able to enhance the activity of cannabinoid-type 2 (CB2) receptors may provide adaptive metabolic advantages and counteract inflammation. In contrast, chronic CB1 receptor activation in hedonic obese individuals may enhance pathophysiological processes related to hyperlipidaemia, diabetes, hepatorenal inflammation and cardiometabolic risk. Food able tomodulate the CB1/CB2 receptor activation ratio may thus play a role in the nutrition transition of Western high-calorie diets. In this review, the interplay between diet and the ECS is highlighted from an evolutionary perspective. The emerging potential of cannabimimetic food as a nutraceutical strategy is critically discussed.
C1 [Gertsch, Jurg] Univ Bern, NCCR TransCure, Inst Biochem & Mol Med, Buhlstr 28, CH-3012 Bern, Switzerland.
C3 University of Bern
RP Gertsch, J (corresponding author), Univ Bern, NCCR TransCure, Inst Biochem & Mol Med, Buhlstr 28, CH-3012 Bern, Switzerland.
EM gertsch@ibmm.unibe.ch
RI Gertsch, Jürg/ITV-6704-2023
OI Andrew, Ruth/0000-0002-6916-2994; Gertsch, Jurg/0000-0003-0978-1555
FU EU MedPlant, a Marie Curie Initial Training Network (ITN)
FX The EU MedPlant, a Marie Curie Initial Training Network (ITN), is
   acknowledged for financial support.
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NR 245
TC 26
Z9 29
U1 0
U2 14
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0007-1188
EI 1476-5381
J9 BRIT J PHARMACOL
JI Br. J. Pharmacol.
PD JUN
PY 2017
VL 174
IS 11
BP 1464
EP 1483
DI 10.1111/bph.13676
PG 20
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA EU7SY
UT WOS:000401236200016
PM 27891602
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU de Freitas, JA
   Santamarina, AB
   Otoch, JP
   Pessoa, AFM
AF de Freitas, Jessica Alves
   Santamarina, Aline Boveto
   Otoch, Jose Pinhata
   Pessoa, Ana Flavia Marcal
TI Silymarin: A Natural Compound for Obesity Management
SO OBESITIES
LA English
DT Review
DE Silybum marianum (L.) gaertn; silymarin; obesity; metabolic diseases;
   phytotherapy; herbal medicine; lipid metabolism; insulin resistance;
   inflammation; antioxidants
ID FATTY LIVER-DISEASE; THISTLE SILYBUM-MARIANUM; ADIPOSE-TISSUE
   DYSFUNCTION; MILK THISTLE; OXIDATIVE STRESS; INSULIN-RESISTANCE;
   METABOLIC SYNDROME; DIABETES-MELLITUS; DRUG INTERACTIONS; SILIBININ
AB Silybum marianum (L.) Gaertn, commonly known as milk thistle, is an herbal medicine rich in silymarin, a bioflavonoid complex. Historically, silymarin was used for treating liver diseases, but recent studies highlight silymarin's potential for obesity management. This narrative review aims to provide an in-depth examination of the existing knowledge of Silybum marianum (L.) and its secondary compounds concerning obesity and associated comorbidities, summarizing data from in vitro, preclinical, and clinical studies. Obesity is a significant public health issue, exacerbated during the COVID-19 pandemic, as a major risk factor for mortality. It contributes to metabolic dysfunction, including oxidative stress, metainflammation, cardiovascular diseases, and type 2 diabetes development. Silymarin has demonstrated benefits on insulin signaling and lipid metabolism, as well as antioxidant and anti-inflammatory properties at the molecular level. Innovative studies also suggest silymarin's potential as a prebiotic, positively influencing gut microbiota composition, a key factor affected by obesity. These promising findings support the potential anti-obesity action of silymarin in clinical practice. Looking forward, using silymarin as an innovative complementary therapy could offer substantial benefits for natural health promotion and obesity management. Nevertheless, further research into optimal doses and cellular mechanisms is still needed.
C1 [de Freitas, Jessica Alves; Santamarina, Aline Boveto; Pessoa, Ana Flavia Marcal] Univ Sao Paulo, HCXFMUSP, Curso Especializacao Fitoterapia & Plantas Medicin, Fac Med, BR-05403010 Sao Paulo, Brazil.
   [de Freitas, Jessica Alves; Santamarina, Aline Boveto; Otoch, Jose Pinhata; Pessoa, Ana Flavia Marcal] Univ Sao Paulo, Dept Cirurgia, Lab Prod & Derivados Nat LIM 26, Fac Med, BR-01246903 Sao Paulo, Brazil.
   [Pessoa, Ana Flavia Marcal] Botanio Pesquisa & Desenvolvimento Ltd, BR-05545010 Sao Paulo, Brazil.
   [Pessoa, Ana Flavia Marcal] Univ Sao Paulo, Dept Doencas Infecciosas & Parasitarias, Lab Parasitol Med LIM 46, Inst Med Trop Sao Paulo, BR-05403000 Sao Paulo, Brazil.
C3 Universidade de Sao Paulo; Universidade de Sao Paulo; Universidade de
   Sao Paulo
RP Pessoa, AFM (corresponding author), Univ Sao Paulo, HCXFMUSP, Curso Especializacao Fitoterapia & Plantas Medicin, Fac Med, BR-05403010 Sao Paulo, Brazil.; Pessoa, AFM (corresponding author), Univ Sao Paulo, Dept Cirurgia, Lab Prod & Derivados Nat LIM 26, Fac Med, BR-01246903 Sao Paulo, Brazil.; Pessoa, AFM (corresponding author), Botanio Pesquisa & Desenvolvimento Ltd, BR-05545010 Sao Paulo, Brazil.; Pessoa, AFM (corresponding author), Univ Sao Paulo, Dept Doencas Infecciosas & Parasitarias, Lab Parasitol Med LIM 46, Inst Med Trop Sao Paulo, BR-05403000 Sao Paulo, Brazil.
EM jessicaalvesdefreitas@alumni.usp.br; alinesantamarina@gmail.com;
   ana.pessoa@fm.usp.br
RI Flavia Marcal Pessoa, Ana/P-7501-2018
OI Flavia Marcal Pessoa, Ana/0000-0003-3979-1607; Santamarina,
   Aline/0009-0004-3109-3745; ALVES DE FREITAS, JESSICA/0000-0002-9457-4587
FX This research received no external funding.
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NR 152
TC 4
Z9 4
U1 1
U2 1
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2673-4168
J9 OBESITIES-BASEL
JI Obesities
PD SEP
PY 2024
VL 4
IS 3
BP 292
EP 313
DI 10.3390/obesities4030024
PG 22
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA H9I0J
UT WOS:001326485300001
OA gold
DA 2025-06-11
ER

PT J
AU da Silva, IF
   Bragante, WR
   Moretti, RCM Jr
   Laurindo, LF
   Guiguer, EL
   Araújo, AC
   Fiorini, AMR
   Nicolau, CCT
   Oshiiwa, M
   de Lima, EP
   Barbalho, SM
   Silva, LR
AF da Silva, Isabela Frazao
   Bragante, Wesley Rossi
   Moretti Junior, Renato Cesar
   Laurindo, Lucas Fornari
   Guiguer, Elen Landgraf
   Araujo, Adriano Cressoni
   Fiorini, Adriana M. R.
   Nicolau, Claudia C. T.
   Oshiiwa, Marie
   de Lima, Enzo Pereira
   Barbalho, Sandra Maria
   Silva, Luis R.
TI Effects of Smallanthus sonchifolius Flour on Metabolic
   Parameters: A Systematic Review
SO PHARMACEUTICALS
LA English
DT Review
DE yacon flour; Smallanthus sonchifolius; glycemia; lipids; metabolic
   syndrome; oxidative stress; inflammation
ID YACON FLOUR; SESQUITERPENE LACTONE; OXIDATIVE STRESS; DIABETIC-RATS;
   DOUBLE-BLIND; LEAVES; ROOTS; INFLAMMATION; ANTIOXIDANT; CONSUMPTION
AB Smallanthus sonchifolius, popularly known as yacon, is a member of the Asteraceae family. Due to its medicinal and edible value, yacon is consumed by different populations. Yacon is unique due to its high fructo-oligosaccharide and inulin content, as well as flavonoids, sesquiterpene lactones, and phenolic acids. Roots can be used to produce flour, which is less perishable and can be applied in various industrial products. This systematic review focuses on the effects of yacon flour on metabolic parameters. PubMed, Cochrane, Embase, Science Direct, Scopus, Web of Science, and Google Scholar databases were consulted, and PRISMA guidelines were followed in the selection of the studies. In total, 526 articles were found in the databases, and of these, only 28 full texts were eligible for inclusion. After applying the inclusion and exclusion criteria, seven studies were finally included. The results showed that the use of yacon flour can reduce glycemia, HbA1c, advanced glycation ends, plasma lipids, body fat mass, body weight, and waist circumference and improve intestinal microbiota and the antioxidant status. Further exploration of the effects of yacon flour is warranted, and additional clinical trials are necessary to determine the optimal daily consumption levels required to assist in improving metabolic parameters.
C1 [da Silva, Isabela Frazao; Bragante, Wesley Rossi; Guiguer, Elen Landgraf; Fiorini, Adriana M. R.; Nicolau, Claudia C. T.; Oshiiwa, Marie; Barbalho, Sandra Maria] Sch Food & Technol Marilia FATEC, Dept Biochem & Nutr, BR-17500000 Sao Paulo, Brazil.
   [Moretti Junior, Renato Cesar; Guiguer, Elen Landgraf; de Lima, Enzo Pereira; Barbalho, Sandra Maria] Univ Marilia UNIMAR, Sch Med, Dept Biochem & Pharmacol, BR-17525902 Sao Paulo, Brazil.
   [Laurindo, Lucas Fornari] Fac Med Marilia FAMEMA, Sch Med, Dept Biochem & Pharmacol, BR-17519030 Sao Paulo, Brazil.
   [Guiguer, Elen Landgraf; Araujo, Adriano Cressoni; Barbalho, Sandra Maria] Univ Marilia UNIMAR, Sch Med, Postgrad Program Struct & Funct Interact Rehabil, BR-17525902 Sao Paulo, Brazil.
   [Barbalho, Sandra Maria] Univ Marilia UNIMAR, UNIMAR Charitable Hosp, BR-17525902 Sao Paulo, Brazil.
   [Silva, Luis R.] Univ Beira Interior, Hlth Sci Res Ctr, CICS UBI, P-6201001 Covilha, Portugal.
   [Silva, Luis R.] Inst Politecn Guarda, SPRINT Sport Phys Act & Hlth Res & Innovat Ctr, P-6300559 Guarda, Portugal.
   [Silva, Luis R.] Univ Coimbra, Dept Chem Engn, CERES, P-3030790 Coimbra, Portugal.
C3 Universidade de Marilia; Faculdade de Medicina de Marilia; Universidade
   de Marilia; Universidade de Marilia; Universidade da Beira Interior;
   Instituto Politecnico da Guarda; Universidade de Coimbra
RP Barbalho, SM (corresponding author), Sch Food & Technol Marilia FATEC, Dept Biochem & Nutr, BR-17500000 Sao Paulo, Brazil.; Barbalho, SM (corresponding author), Univ Marilia UNIMAR, Sch Med, Dept Biochem & Pharmacol, BR-17525902 Sao Paulo, Brazil.; Barbalho, SM (corresponding author), Univ Marilia UNIMAR, Sch Med, Postgrad Program Struct & Funct Interact Rehabil, BR-17525902 Sao Paulo, Brazil.; Barbalho, SM (corresponding author), Univ Marilia UNIMAR, UNIMAR Charitable Hosp, BR-17525902 Sao Paulo, Brazil.; Silva, LR (corresponding author), Univ Beira Interior, Hlth Sci Res Ctr, CICS UBI, P-6201001 Covilha, Portugal.; Silva, LR (corresponding author), Inst Politecn Guarda, SPRINT Sport Phys Act & Hlth Res & Innovat Ctr, P-6300559 Guarda, Portugal.; Silva, LR (corresponding author), Univ Coimbra, Dept Chem Engn, CERES, P-3030790 Coimbra, Portugal.
EM smbarbalho@gmail.com; luisfarmacognosia@gmail.com
RI Araujo, Adriano/AAN-1823-2020; FORNARI LAURINDO, LUCAS/AAC-8677-2022;
   Silva, Luis Rodrigues da/D-5485-2013; barbalho, sandra/Z-3515-2019;
   Guiguer, Elen/AAN-1883-2020
OI FORNARI LAURINDO, LUCAS/0000-0003-3159-0982; Silva, Luis Rodrigues
   da/0000-0001-5264-3516; barbalho, sandra/0000-0002-5035-876X; Pereira de
   Lima, Enzo/0009-0004-4651-3140; Guiguer, Elen/0000-0002-9930-9694
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NR 79
TC 5
Z9 5
U1 6
U2 12
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1424-8247
J9 PHARMACEUTICALS-BASE
JI Pharmaceuticals
PD MAY
PY 2024
VL 17
IS 5
AR 658
DI 10.3390/ph17050658
PG 15
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA SH7V6
UT WOS:001233639000001
PM 38794228
OA gold
DA 2025-06-11
ER

PT J
AU Klandorf, H
   Dartigue, V
AF Klandorf, Hillar
   Dartigue, Vincent
TI Oxidative stress and plasma ceramides in broiler chickens
SO FRONTIERS IN PHYSIOLOGY
LA English
DT Article
DE sphingolipid ceramides; oxidative stress; lipidomic approach; broiler
   chickens; allopurinol
ID PROTEIN-SYNTHESIS; URIC-ACID; XANTHINE OXIDOREDUCTASE; LIVER; GLUCOSE;
   INFLAMMATION; ALLOPURINOL; EXPRESSION; LIPOLYSIS; KINASE
AB The selection for rapid growth in chickens has rendered meat-type (broiler) chickens susceptible to develop metabolic syndrome and thus inflammation. The sphingolipid ceramide has been linked as a marker of oxidative stress in mammals, however, the relationship between sphingolipid ceramide supply and oxidative stress in broiler chickens has not been investigated. Therefore, we employed a lipidomic approach to investigate the changes in circulating sphingolipid ceramides in context of allopurinol-induced oxidative stress in birds. Day zero hatched chicks (n = 60) were equally divided into six groups; an unsupplemented control, an allopurinol group (25 mg/kg body weight), a conjugated linoleic acid (CLA) group where half of the oil used in the control diet was substituted for a CLA oil mixture, a CLA and an allopurinol group utilizing the same dose of CLA and allopurinol, a berberine (BRB) group consisting of berberine supplementation (200 mg/kg feed), and a BRB and allopurinol group, utilizing the same dose of BRB and allopurinol. Conjugated linoleic acid and berberine were utilized to potentially enhance antioxidant activity and suppress the oxidative stress induced by allopurinol treatment. Body weight, plasma uric acid, nonesterified fatty acids (NEFA) and sphingolipid ceramides were quantified. Allopurinol induced an inflammatory state as measured by a significant reduction in plasma uric acid - an antioxidant in birds as well as a metabolic waste product. Results showed that both total and saturated sphingolipid ceramides declined (p < 0.05) with age in unsupplemented chicks, although plasma ceramides C16:0 and 18:0 increased in concentration over the study period. Simple total and saturated sphingolipid ceremide's were further decreased (p < 0.05) with allopurinol supplementation, however, this may be an indirect consequence of inducing an inflammatory state. Neither CLA or BRB were able to significantly attenuate the decline. The administration of allopurinol specifically targets the liver which in birds, is the primary organ for fatty acids synthesis. For this reason, sphingolipid ceramide production might have been unwittingly affected by the addition of allopurinol.
C1 [Klandorf, Hillar; Dartigue, Vincent] West Virginia Univ, Div Anim & Nutr Sci, Morgantown, WV 26505 USA.
C3 West Virginia University
RP Klandorf, H (corresponding author), West Virginia Univ, Div Anim & Nutr Sci, Morgantown, WV 26505 USA.
EM hillar.klandorf@mail.wvu.edu
FU Hatch Grant [WVA00678]
FX Scientific Article No: 3473 of the West Virginia Agricultural and
   Forestry Experiment Station, Morgantown. Our thanks are given to Zach
   Phipps, Elizabeth Falkenstein and Dr. Eduardo Rico for help with
   collecting the research data and for the support of the West Virginia
   University farm crew. We are grateful for a grant from the Davis College
   to pay for the ceramide analyses in the McFadden lab and to Dr. Jesse
   Kraus (Dept. of Biology, University of Reno, NV) for his careful review
   of the manuscript.
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NR 36
TC 0
Z9 0
U1 0
U2 1
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1664-042X
J9 FRONT PHYSIOL
JI Front. Physiol.
PD JUL 15
PY 2024
VL 15
AR 1411332
DI 10.3389/fphys.2024.1411332
PG 8
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA A0L9A
UT WOS:001279551300001
PM 39077757
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Portero-Otin, M
   de la Maza, MP
   Uribarri, J
AF Portero-Otin, Manuel
   de la Maza, M. Pia
   Uribarri, Jaime
TI Dietary Advanced Glycation End Products: Their Role in the Insulin
   Resistance of Aging
SO CELLS
LA English
DT Review
DE insulin resistance; glycation; oxidative stress; inflammation;
   ultraprocessed foods
ID METABOLIC SYNDROME; GUT MICROBIOTA; DIABETES-MELLITUS; OXIDATIVE STRESS;
   AGE RESTRICTION; SENSITIVITY; RECEPTOR; INFLAMMATION; GLUCOSE; OBESITY
AB Insulin resistance (IR) is commonly observed during aging and is at the root of many of the chronic nontransmissible diseases experienced as people grow older. Many factors may play a role in causing IR, but diet is undoubtedly an important one. Whether it is total caloric intake or specific components of the diet, the factors responsible remain to be confirmed. Of the many dietary influences that may play a role in aging-related decreased insulin sensitivity, advanced glycation end products (AGEs) appear particularly important. Herein, we have reviewed in detail in vitro, animal, and human evidence linking dietary AGEs contributing to the bodily burden of AGEs with the development of IR. We conclude that numerous small clinical trials assessing the effect of dietary AGE intake in combination with strong evidence in many animal studies strongly suggest that reducing dietary AGE intake is associated with improved IR in a variety of disease conditions. Reducing AGE content of common foods by simple changes in culinary techniques is a feasible, safe, and easily applicable intervention in both health and disease. Large-scale clinical trials are still needed to provide broader evidence for the deleterious role of dietary AGEs in chronic disease.
C1 [Portero-Otin, Manuel] Univ Lleida, Fac Med, Dept Med Expt, Lleida 25196, Spain.
   [de la Maza, M. Pia] Univ Desarrollo, Dept Med, Clin Alemana, Ctr Nutr & Diabet, Santiago 7610658, Chile.
   [Uribarri, Jaime] Icahn Sch Med Mt Sinai, Dept Med, New York, NY 10021 USA.
C3 Universitat de Lleida; Clinica Alemana; Universidad del Desarrollo;
   Icahn School of Medicine at Mount Sinai
RP Uribarri, J (corresponding author), Icahn Sch Med Mt Sinai, Dept Med, New York, NY 10021 USA.
EM manuel.portero@mex.udl.cat; mariapiadelamaza@gmail.com;
   jaime.uribarri@mountsinai.org
RI Portero-Otin, Manuel/B-7122-2009; Uribarri, Jaime/ADX-7655-2022
OI Portero-Otin, Manuel/0000-0002-1823-0299; uribarri,
   jaime/0000-0001-9826-1134
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NR 84
TC 15
Z9 15
U1 2
U2 11
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2073-4409
J9 CELLS-BASEL
JI Cells
PD JUL
PY 2023
VL 12
IS 13
AR 1684
DI 10.3390/cells12131684
PG 13
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA M2OT9
UT WOS:001028633400001
PM 37443718
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Chen, ZF
   Liang, S
   Bai, YL
   Lin, JL
   Li, ML
   Mo, ZN
   Xie, SS
   Huang, SS
   Long, JX
AF Chen, Zefeng
   Liang, Shuang
   Bai, Yulan
   Lin, Jiali
   Li, Mingli
   Mo, Zengnan
   Xie, Sisi
   Huang, ShiShan
   Long, Jianxiong
TI Serum uric acid is not associated with major depressive disorder in
   European and South American populations: a meta-analysis and two-sample
   bidirectional Mendelian Randomization study
SO EUROPEAN JOURNAL OF CLINICAL NUTRITION
LA English
DT Article
ID TERM ANTIDEPRESSANT TREATMENT; OXIDATIVE STRESS PARAMETERS; BIPOLAR
   DISORDER; NITROSATIVE STRESS; METABOLIC SYNDROME; MOOD; RISK; MORTALITY;
   SYMPTOMS; PATHWAYS
AB Objective Although previous epidemiological studies have demonstrated that serum uric acid (SUA) is associated with major depressive disorder (MDD), these analyses are prone to biases. Here, we applied the Mendelian Randomization approach to determine whether SUA is causally associated with MDD. Methods We conducted a meta-analysis to evaluate the relationship between SUA and MDD, then applied summary data from the Global Urate Genetics Consortium and the Psychiatric Genomics Consortium to estimate their causal effect using a two-sample bidirectional Mendelian Randomization (MR) analysis. Thereafter, the causal effect was further researched using genetic risk scores (GRS) as instrumental variables (IVs). Results Results of a meta-analysis of articles comprising 6975 and 13,589 MDD patients and controls, respectively, revealed that SUA was associated with MDD (SMD = -0.690, 95% CI: -0.930 to -0.440, I-2 = 97.4%, P < 0.001). In addition, the five MR methods revealed no causal relationship existed between SUA and MDD, which corroborated the results obtained via the GRS approach. Conclusion This paper found little evidence that this association between SUA and MDD is casual. Genetically, there was no significant causal association between SUA and MDD.
C1 [Chen, Zefeng; Huang, ShiShan] Guangxi Acad Med Sci, Peoples Hosp Guangxi Zhuang Autonomous Reg, Sci Res Dept, 6 Taoyuan Rd, Nanning 530021, Peoples R China.
   [Liang, Shuang; Bai, Yulan; Lin, Jiali; Li, Mingli; Mo, Zengnan] Guangxi Med Univ, Ctr Genom & Personalized Med, Nanning 530021, Guangxi, Peoples R China.
   [Liang, Shuang; Bai, Yulan; Lin, Jiali; Li, Mingli; Mo, Zengnan] Guangxi Key Lab Genom & Personalized Med, Nanning 530021, Guangxi, Peoples R China.
   [Liang, Shuang; Bai, Yulan; Lin, Jiali; Li, Mingli; Mo, Zengnan; Long, Jianxiong] Guangxi Med Univ, Sch Publ Hlth, Nanning 530021, Guangxi, Peoples R China.
   [Mo, Zengnan] Guangxi Med Univ, Affiliated Hosp 1, Inst Urol & Nephrol, Nanning 530021, Guangxi, Peoples R China.
   [Xie, Sisi] Guangxi Med Univ, Affiliated Hosp 1, Dept Radiol, Nanning 530021, Guangxi, Peoples R China.
C3 Guangxi Medical University; Guangxi Medical University; Guangxi Medical
   University; Guangxi Medical University
RP Chen, ZF (corresponding author), Guangxi Acad Med Sci, Peoples Hosp Guangxi Zhuang Autonomous Reg, Sci Res Dept, 6 Taoyuan Rd, Nanning 530021, Peoples R China.; Long, JX (corresponding author), Guangxi Med Univ, Sch Publ Hlth, Nanning 530021, Guangxi, Peoples R China.
EM 1273812311@qq.com; 583839475@qq.com
RI liang, shuang/JOK-5869-2023
FU Major Project of Guangxi Innovation Driven [AA18118016]; National Key
   Research and Development Program of China [2017YFC0908000]; Scientific
   Research and Technology Development Program of Guangxi [15277004]
FX We would like to acknowledge the Global Urate Genetics Consortium (GUGC)
   and the Psychiatric Genomics Consortium (PGC) for supplying the summary
   data. This study was funded by the Major Project of Guangxi Innovation
   Driven (AA18118016), National Key Research and Development Program of
   China (2017YFC0908000), Scientific Research and Technology Development
   Program of Guangxi (15277004).
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NR 61
TC 2
Z9 2
U1 3
U2 8
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0954-3007
EI 1476-5640
J9 EUR J CLIN NUTR
JI Eur. J. Clin. Nutr.
PD DEC
PY 2022
VL 76
IS 12
BP 1665
EP 1674
DI 10.1038/s41430-022-01165-8
EA MAY 2022
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 6O6GH
UT WOS:000801969100001
PM 35614209
DA 2025-06-11
ER

PT J
AU Hsu, CN
   Hou, CY
   Tain, YL
AF Hsu, Chien-Ning
   Hou, Chih-Yao
   Tain, You-Lin
TI Preventive Aspects of Early Resveratrol Supplementation in
   Cardiovascular and Kidney Disease of Developmental Origins
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE resveratrol; oxidative stress; chronic kidney disease; cardiovascular
   disease; hypertension; developmental origins of health and disease
   (DOHaD); gut microbiota; nitric oxide
ID HIGH-FAT DIET; PROLIFERATOR-ACTIVATED RECEPTORS; INDUCED PROGRAMMED
   HYPERTENSION; OXIDATIVE STRESS; METABOLIC SYNDROME; TRANS-RESVERATROL;
   BLOOD-PRESSURE; MATERNAL NUTRITION; AGENT RESVERATROL; PRENATAL HYPOXIA
AB The increase in the incidence of cardiovascular diseases (CVDs) and kidney disease has stimulated research for strategies that could prevent, rather than just treat, both interconnected disorders. Resveratrol, a polyphenolic compound with pleiotropic biofunctions, has shown health benefits. Emerging epidemiological data supports that early life environmental insults are regarded as increased risks of developing CVDs and kidney disease in adulthood. Conversely, both disorders could be reversed or postponed by shifting interventions from adulthood to earlier stage by so-called reprogramming. The purpose of this review is first to highlight current epidemiological studies linking cardiovascular and renal programming to resulting CVD and kidney disease of developmental origins. This will be followed by a summary of how resveratrol could exert a positive influence on CVDs and kidney disease. This review also presents an overview of the evidence documenting resveratrol as a reprogramming agent to protect against CVD and kidney disease of developmental origins from animal studies and to outline the advances in understanding the underlying molecular mechanisms. Overall, this review reveals the need for future research to further clarify the reprogramming effects of resveratrol before clinical translation.
C1 [Hsu, Chien-Ning] Kaohsiung Chang Gung Mem Hosp, Dept Pharm, Kaohsiung 833, Taiwan.
   [Hsu, Chien-Ning] Kaohsiung Med Univ, Sch Pharm, Kaohsiung 807, Taiwan.
   [Hou, Chih-Yao] Natl Kaohsiung Univ Sci & Technol, Dept Seafood Sci, Kaohsiung 811, Taiwan.
   [Tain, You-Lin] Kaohsiung Chang Gung Mem Hosp, Dept Pediat, Kaohsiung 833, Taiwan.
   [Tain, You-Lin] Chang Gung Univ, Coll Med, Kaohsiung 833, Taiwan.
   [Tain, You-Lin] Kaohsiung Chang Gung Mem Hosp, Inst Translat Res Biomed, Kaohsiung 833, Taiwan.
C3 Chang Gung Memorial Hospital; Kaohsiung Medical University; National
   Kaohsiung University of Science & Technology; Chang Gung Memorial
   Hospital; Chang Gung University; Chang Gung Memorial Hospital
RP Tain, YL (corresponding author), Kaohsiung Chang Gung Mem Hosp, Dept Pediat, Kaohsiung 833, Taiwan.; Tain, YL (corresponding author), Chang Gung Univ, Coll Med, Kaohsiung 833, Taiwan.; Tain, YL (corresponding author), Kaohsiung Chang Gung Mem Hosp, Inst Translat Res Biomed, Kaohsiung 833, Taiwan.
EM cnhsu@cgmh.org.tw; chihyaohou@webmail.nkmu.edu.tw; tainyl@cgmh.org.tw
RI Tain, You-Lin/H-2827-2019; Hsu, Chien-Ning/GLS-4014-2022; HOU,
   CHIH/S-4983-2018
OI Hsu, Chien-Ning/0000-0001-7470-528X; Hou, Chih-Yao/0000-0002-8007-6077;
   Tain, You-Lin/0000-0002-7059-6407
FU Chang Gung Memorial Hospital, Kaohsiung, Taiwan [CORPG8L0301,
   CMRPG8J0252, CMRPG8J0892]
FX This research was funded by Chang Gung Memorial Hospital, Kaohsiung,
   Taiwan, grants CORPG8L0301, CMRPG8J0252, and CMRPG8J0892.
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NR 156
TC 29
Z9 30
U1 0
U2 7
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD APR
PY 2021
VL 22
IS 8
AR 4210
DI 10.3390/ijms22084210
PG 18
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA RT3JG
UT WOS:000644357900001
PM 33921641
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Mitsunari, K
   Miyata, Y
   Matsuo, T
   Mukae, Y
   Otsubo, A
   Harada, J
   Kondo, T
   Matsuda, T
   Ohba, K
   Sakai, H
AF Mitsunari, Kensuke
   Miyata, Yasuyoshi
   Matsuo, Tomohiro
   Mukae, Yuta
   Otsubo, Asato
   Harada, Junki
   Kondo, Tsubasa
   Matsuda, Tsuyoshi
   Ohba, Kojiro
   Sakai, Hideki
TI Pharmacological Effects and Potential Clinical Usefulness of Polyphenols
   in Benign Prostatic Hyperplasia
SO MOLECULES
LA English
DT Review
DE polyphenols; flavonoids; pharmacological effect; benign prostatic
   hyperplasia
ID URINARY-TRACT SYMPTOMS; GREEN TEA POLYPHENOL; OXIDATIVE STRESS;
   METABOLIC SYNDROME; DIETARY ISOFLAVONES; ANDROGEN RECEPTOR; SOY
   ISOFLAVONES; LNCAP CELLS; TESTOSTERONE; CANCER
AB Benign prostatic hyperplasia (BPH) is arguably the most common benign disease among men. This disease is often associated with lower urinary tract symptoms (LUTS) in men and significantly decreases the quality of life. Polyphenol consumption reportedly plays an important role in the prevention of many diseases, including BPH. In recent years, in addition to disease prevention, many studies have reported the efficacy and safety of polyphenol treatment against various pathological conditions in vivo and in vitro. Furthermore, numerous studies have also revealed the molecular mechanisms of the antioxidant and anti-inflammatory effects of polyphenols. We believe that an improved understanding of the detailed pharmacological roles of polyphenol-induced activities at a molecular level is important for the prevention and treatment of BPH. Polyphenols are composed of many members, and their biological roles differ. In this review, we first provide information regarding the pathological roles of oxidative stress and inflammation in BPH. Next, the antioxidant and anti-inflammatory effects of polyphenols, including those of flavonoids and non-flavonoids, are discussed. Finally, we talk about the results and limitations of previous clinical trials that have used polyphenols in BPH, with particular focus on their molecular mechanisms of action.
C1 [Mitsunari, Kensuke; Miyata, Yasuyoshi; Matsuo, Tomohiro; Mukae, Yuta; Otsubo, Asato; Harada, Junki; Kondo, Tsubasa; Matsuda, Tsuyoshi; Ohba, Kojiro; Sakai, Hideki] Nagasaki Univ, Dept Urol, Grad Sch Biomed Sci, Nagasaki 8528501, Japan.
C3 Nagasaki University
RP Miyata, Y (corresponding author), Nagasaki Univ, Dept Urol, Grad Sch Biomed Sci, Nagasaki 8528501, Japan.
EM ken.mitsunari@gmail.com; yasu-myt@nagasaki-u.ac.jp;
   tomozo1228@hotmail.com; ytmk_n2@yahoo.co.jp; a.06131dpsc@gmail.com;
   harada_junki_19881027@yahoo.co.jp; t-udonko@nagasaki-u.ac.jp;
   matsudatsuyoshi9251@gmail.com; ohba-k@nagasaki-u.ac.jp;
   hsakai@nagasaki-u.ac.jp
RI mitsunari, kensuke/ABI-1916-2020
OI mitsunari, kensuke/0000-0002-6963-5632; Miyata,
   Yasuyoshi/0000-0001-6272-6657; Matsuo, Tomohiro/0000-0002-9508-0319;
   ohba, kojiro/0000-0003-2841-1998
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NR 134
TC 24
Z9 24
U1 1
U2 26
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1420-3049
J9 MOLECULES
JI Molecules
PD JAN
PY 2021
VL 26
IS 2
AR 450
DI 10.3390/molecules26020450
PG 20
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA PX6OM
UT WOS:000611473600001
PM 33467066
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Gulum, M
   Gumus, K
   Yeni, E
   Dogantekin, E
   Ciftci, H
   Akin, Y
   Savas, M
   Altunkol, A
AF Gulum, M.
   Gumus, K.
   Yeni, E.
   Dogantekin, E.
   Ciftci, H.
   Akin, Y.
   Savas, M.
   Altunkol, A.
TI Blood and semen paraoxonase-arylesterase activities in normozoospermic
   and azoospermic men
SO ANDROLOGIA
LA English
DT Article
DE arylesterase; azoospermic; normozoospermic; paraoxonase; semen
ID TADALAFIL 5 MG; BENIGN PROSTATIC HYPERPLASIA; LEYDIG-CELL
   STEROIDOGENESIS; URINARY-TRACT SYMPTOMS; ERECTILE DYSFUNCTION; METABOLIC
   SYNDROME; RISK-FACTORS; SILDENAFIL CITRATE; TESTOSTERONE LEVELS; SEXUAL
   DYSFUNCTION
AB Paraoxonase and arylesterase enzymes are corner stones of antioxidant defence. We aimed to compare azoospermic infertile men and normozoospermic individuals with respect to total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), paraoxonase and arylesterase levels in the blood and seminal plasma. Two-hundred consecutive infertility patients and voluntarily participated were included. In the normozoospermic group, TAS, PON, arylesterase values were statistically significantly higher when compared with those in the azoospermic group, while lower TOS and OSI levels were observed in the blood and seminal plasma of azoospermic group. In the semen analyses of normozoospermic group, the correlation between semen volume, sperm concentration, sperm motility and morphology and TAS, TOS, OSI, PON and arylesterase values was examined. A negative correlation was determined between semen volume and OSI. Levels of serum oxidative parameters were higher in the azoospermic group relative to normozoospermic group, but antioxidant parameters were lower than those of the normozoospermic group. Oxidative stress performs an essential role in the aetiology of male infertility by negatively influencing sperm quality and function. Assessment of blood and seminal plasma oxidative profiles might be an important tool to better evaluation of sperm reproductive capacity and functional competence.
C1 [Gulum, M.; Dogantekin, E.] Hacettepe Univ, Fac Med, Dept Urol, Ankara, Turkey.
   [Gumus, K.] Balikligol Hosp, Dept Urol, Sanliurfa, Turkey.
   [Yeni, E.; Ciftci, H.; Akin, Y.] Harran Univ, Fac Med, Dept Urol, Sanliurfa, Turkey.
   [Savas, M.] Antalya Training & Res Hosp, Dept Urol, Antalya, Turkey.
   [Altunkol, A.] Adana Training & Res Hosp, Dept Urol, Adana, Turkey.
C3 Hacettepe University; Sanliurfa Balikligol State Hospital; Harran
   University; Antalya Training & Research Hospital; Adana Numune Training
   & Research Hospital
RP Gulum, M (corresponding author), Hacettepe Univ, Fac Med, Dept Urol, Ankara, Turkey.
EM mehmetgulum@hotmail.com
RI AKIN, Yigit/AAD-5481-2019; ciftci, Halil/ABF-3298-2020; Savas,
   Murat/AAD-5570-2019; Gumus, Kemal/GXG-7654-2022; savas,
   murat/V-1548-2017
OI Gumus, Kemal/0000-0001-9805-7387; savas, murat/0000-0002-3068-4699;
   Gulum, Mehmet/0000-0003-4926-0252
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NR 36
TC 10
Z9 10
U1 0
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0303-4569
EI 1439-0272
J9 ANDROLOGIA
JI Andrologia
PD NOV
PY 2017
VL 49
IS 9
AR e12752
DI 10.1111/and.12752
PG 5
WC Andrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA FJ6BI
UT WOS:000412838200011
PM 28000956
DA 2025-06-11
ER

PT J
AU Karakurt, Ö
   Cagirci, G
   Eryasar, NE
AF Karakurt, Ozlem
   Cagirci, Goksel
   Eryasar, Neslihan Ebru
TI Gamma-glutamyl transferase activity increases in prehypertensive
   patients
SO TURKISH JOURNAL OF MEDICAL SCIENCES
LA English
DT Article
DE GGT; prehypertension; cardiovascular
ID CARDIOVASCULAR-DISEASE; HEART-DISEASE; RISK-FACTOR; ASSOCIATION;
   TRANSPEPTIDASE; MORTALITY; GLUTAMYLTRANSFERASE; DETERMINANTS; PRESSURE;
   ENZYME
AB Aim: To investigate the association between serum gamma-glutamyl transferase (gamma-glutamyl transpeptidase, GGT) levels and prehypertension in a nationally representative sample of Turkish adults. GGT is an enzyme present in serum and most cell surfaces. It is used as an oxidative stress marker. Increased serum GGT levels are implicated in increased blood pressure and the progression of hypertension. GGT may also have a role in the pathogenesis of cardiovascular disease, diabetes mellitus, obstructive sleep apnea syndrome, and metabolic syndrome.
   Materials and methods: Prehypertension was identified as systolic blood pressure ranging from 120 to 139 mmHg or diastolic blood pressure ranging from 80 to 89 mmHg. Enrolled in this study were 23 female and 45 male patients in the prehypertensive group (Group 1; mean age of 44.6 +/- 11.2 years) and 25 female and 43 male patients in the normotensive group (Group 2; mean age of 43.3 +/- 7.0 years). The serum GGT activity of these patients was measured.
   Results: The mean GGT activities were significantly higher in the prehypertension group than in the control group (24.33 and 18.85 U/L, respectively; P < 0.001).
   Conclusion: Elevated GGT levels in prehypertensive individuals support the idea that these patients are under increased oxidative stress. Even in the prehypertensive stage, it is essential to manage strict cardiovascular risk factor modifications.
C1 [Karakurt, Ozlem] Balikesir Govt Hosp, Dept Cardiol, Balikesir, Turkey.
   [Cagirci, Goksel; Eryasar, Neslihan Ebru] Diskapi Yildirim Beyazit Educ & Res Hosp, Minist Hlth, Dept Cardiol Clin, Ankara, Turkey.
C3 Balikesir Ataturk State Hospital; Ministry of Health - Turkey; Diskapi
   Yildirim Beyazit Training & Research Hospital
RP Karakurt, Ö (corresponding author), Balikesir Govt Hosp, Dept Cardiol, Balikesir, Turkey.
EM ozlemkarakurt55@yahoo.com
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NR 24
TC 2
Z9 2
U1 0
U2 0
PU Tubitak Scientific & Technological Research Council Turkey
PI ANKARA
PA ATATURK BULVARI NO 221, KAVAKLIDERE, TR-06100 ANKARA, TURKIYE
SN 1300-0144
EI 1303-6165
J9 TURK J MED SCI
JI Turk. J. Med. Sci.
PD DEC
PY 2011
VL 41
IS 6
BP 975
EP 980
DI 10.3906/sag-1006-865
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 863VZ
UT WOS:000298197700004
OA Bronze
DA 2025-06-11
ER

PT J
AU Erkonen, GE
   Hermann, GM
   Miller, RL
   Thedens, DL
   Nopoulos, PC
   Wemmie, JA
   Roghair, RD
AF Erkonen, Gwen E.
   Hermann, Gregory M.
   Miller, Rachel L.
   Thedens, Daniel L.
   Nopoulos, Peg C.
   Wemmie, John A.
   Roghair, Robert D.
TI Neonatal Leptin Administration Alters Regional Brain Volumes and Blocks
   Neonatal Growth Restriction-Induced Behavioral and Cardiovascular
   Dysfunction in Male Mice
SO PEDIATRIC RESEARCH
LA English
DT Article
ID POSTTRAUMATIC-STRESS-DISORDER; BIRTH-WEIGHT; ADULT RATS; BASOLATERAL
   AMYGDALA; CHILDHOOD GROWTH; PRETERM CHILDREN; GESTATIONAL-AGE; CATCH-UP;
   AUTISM; HYPERTENSION
AB Premature delivery is often complicated by neonatal growth restriction (GR) and neurodevelopmental impairment. Because global overnutrition increases the risk of adult metabolic syndrome, we sought a targeted intervention. Premature delivery and perinatal GR decrease circulating levels of the neurotrophic hormone leptin. We hypothesized that leptin supplementation would normalize the outcomes of mice with incipient neonatal GR. Pups were fostered into litters of 6 or 12 to elicit divergent growth patterns. Pups in each litter received injections of saline or leptin from d 4 to 14. At 4 mo, mice underwent tail cuff blood pressure measurement, behavioral testing, and MRI. Mice fostered in litters of 12 had decreased weanling weights and leptin levels. Neonatal leptin administration normalized plasma leptin levels without influencing neonatal growth. Leptin replacement also normalized the hypertension, stress-linked immobility, conditioned fear, and amygdala enlargement seen in neonatal growth restricted male mice. In control males, neonatal leptin administration led to hypothalamic enlargement, without overt neurocardiovascular alterations. Female mice were less susceptible to the effects of neonatal GR or leptin supplementation. In conclusion, the effects of neonatal leptin administration are modulated by concurrent growth and gender. In growth restricted male mice, physiologic leptin replacement improves adult neurocardiovascular outcomes. (Pediatr Res 69: 406-412, 2011)
C1 [Erkonen, Gwen E.; Hermann, Gregory M.; Miller, Rachel L.; Roghair, Robert D.] Univ Iowa, Coll Med, Dept Pediat, Iowa City, IA 52242 USA.
   [Thedens, Daniel L.] Univ Iowa, Coll Med, Dept Radiol, Iowa City, IA 52242 USA.
   [Nopoulos, Peg C.; Wemmie, John A.] Univ Iowa, Coll Med, Dept Psychiat, Iowa City, IA 52242 USA.
   [Wemmie, John A.] Vet Affairs Med Ctr, Iowa City, IA 52246 USA.
C3 University of Iowa; University of Iowa; University of Iowa; US
   Department of Veterans Affairs; Veterans Health Administration (VHA);
   Iowa City VA Health Care System
RP Roghair, RD (corresponding author), Univ Iowa, Coll Med, Dept Pediat, 1270 CBRB, Iowa City, IA 52242 USA.
EM robert-roghair@uiowa.edu
RI Miller, Rachel/Q-9066-2017; Roghair, Robert/MAH-5050-2025
OI Nopoulos, Peggy/0000-0001-8810-1903; Roghair,
   Robert/0000-0002-0321-582X; Wemmie, John/0000-0001-7531-9065
FU Children's Miracle Network; National Institutes of Health [HL102659]
FX Supported by grants from the Children's Miracle Network and the National
   Institutes of Health (HL102659).
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NR 40
TC 21
Z9 21
U1 0
U2 7
PU INT PEDIATRIC RESEARCH FOUNDATION, INC
PI BALTIMORE
PA 351 W CAMDEN ST, BALTIMORE, MD 21201-2436 USA
SN 0031-3998
J9 PEDIATR RES
JI Pediatr. Res.
PD MAY
PY 2011
VL 69
IS 5
BP 406
EP 412
DI 10.1203/PDR.0b013e3182110c7d
PN 1
PG 7
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA 753WN
UT WOS:000289811000007
PM 21258265
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Chen, T
   Ren, Y
   Liu, YY
   Long, Y
   Zhang, XX
   Yu, HL
   Xu, J
   Yu, T
   Tian, HM
AF Chen, Tao
   Ren, Yan
   Liu, Yuanyuan
   Long, Yang
   Zhang, Xiangxun
   Yu, Hongling
   Xu, Jin
   Yu, Ting
   Tian, Haoming
TI Serum gamma-glutamyl transferase, ferritin and the risk of type 2
   diabetes in women from a Chinese minority
SO DIABETES RESEARCH AND CLINICAL PRACTICE
LA English
DT Article
DE Gamma-glutamyl transferase; Ferritin; Type 2 diabetes; Oxidative stress
ID METABOLIC SYNDROME; IRON INTAKE; MEAT INTAKE; MEN; POPULATION; ADULTS;
   ASSOCIATION; FAT
AB Aims: This study was to investigate the relationship of gamma-glutamyl transferase to ferritin, and their interaction on the risk of type 2 diabetes.
   Subjects and methods: A total of 436 men and 588 women were recruited. According to levels of GGT and ferritin, they were divided into three groups in each gender of each geological location (Urban or Rural), that is, Group 1 (both GGT and ferritin < median values), Group 2 (only GGT or ferritin >= median values), and group 3 (both GGT and ferritin >= median values). Odds ratios for T2D in group 2-3 compared with group 1 were analyzed by multiple logistic regressions.
   Results: (1) The prevalence of glucose abnormalities increased across the three groups of female subjects. Correspondingly, MDA levels were also higher in group 3 than other groups. (2) GGT and ferritin were correlated with each other after controlling for BMI. (3) T2D risk was higher in group 3 than that in group 1 in female subjects, which was independent of age, BMI, and T2D family history.
   Conclusions: GGT and ferritin were correlated with each other, and had synergetic effect on the risk of T2D in women. The mechanism might be involved in enhanced oxidative stress. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
C1 [Chen, Tao; Ren, Yan; Liu, Yuanyuan; Tian, Haoming] Sichuan Univ, W China Hosp, Dept Endocrinol & Metab, Chengdu 610041, Peoples R China.
   [Liu, Yuanyuan] Chengdu Univ, Affiliated Hosp 3, Tradit Chinese Med Diabet Mellitus Prevent & Cure, Chengdu 610041, Sichuan Prov, Peoples R China.
   [Long, Yang; Zhang, Xiangxun; Yu, Hongling; Tian, Haoming] Sichuan Univ, W China Hosp, Lab Endocrinol & Metab, Chengdu 610041, Peoples R China.
   [Xu, Jin; Yu, Ting] Sichuan Univ, W China Hosp, Dept Lab Med, Chengdu 610041, Peoples R China.
C3 Sichuan University; Chengdu University; Sichuan University; Sichuan
   University
RP Tian, HM (corresponding author), Sichuan Univ, W China Hosp, Dept Endocrinol & Metab, 37 GuoXue St, Chengdu 610041, Peoples R China.
EM hmtian999@yahoo.com.cn
RI yu, ting/KBD-0922-2024
OI Chen, Tao/0000-0002-8371-779X; Tian, Haoming/0000-0002-1921-4733; Chen,
   Tao/0000-0003-4888-1292
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NR 20
TC 11
Z9 11
U1 0
U2 8
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0168-8227
EI 1872-8227
J9 DIABETES RES CLIN PR
JI Diabetes Res. Clin. Pract.
PD DEC
PY 2010
VL 90
IS 3
BP 352
EP 357
DI 10.1016/j.diabres.2010.09.017
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 698XU
UT WOS:000285629300031
PM 20970869
DA 2025-06-11
ER

PT J
AU Priyanka, DN
   Prashanth, KVH
AF Priyanka, D. N.
   Prashanth, K. V. Harish
TI Low molecular weight chitosan (∼20 kDa) exhibits in vivo
   anti-hyperglycemic effects through AKT/PI3K/FOXO pathway
SO CARBOHYDRATE POLYMER TECHNOLOGIES AND APPLICATIONS
LA English
DT Article
DE Low molecular weight chitosan; Water soluble; Hyperglycemia;
   Antidiabetic supplement; Dyslipidemia; T1DM
ID DIABETES-MELLITUS; OXIDATIVE STRESS; AQUEOUS EXTRACT; BLOOD-GLUCOSE;
   TYPE-1; OLIGOSACCHARIDES; POLYSACCHARIDE; ASSOCIATION; RETINOPATHY;
   ABSORPTION
AB Diabetes, a metabolic syndrome, is a leading global cause of morbidity and mortality. Dietary polysaccharide intervention besides medication, helps in diabetes through managing blood glucose levels. The present study elucidates the anti-hyperglycemic mechanism of water-soluble LMWC (similar to 20 kDa), the chitosan derivative, in type-1 diabetic (T1DM) male Wistar rats induced by streptozotocin (STZ, 36 mg/kg b.w.). LMWC1 (100 mg/kg b. w.) and LMWC2 (250 mg/kg b.w.) were administered orally on alternative days for 4 weeks. LMWC lowered fasting blood glucose levels and improved symptoms like polyphagia, polydipsia, polyuria, and serum insulin levels in a dose-dependent manner. It also ameliorated hyperglycemia & dyslipidemia by mitigating the levels of pro-inflammatory factors and oxidative stress levels in the pancreas and liver. Additionally, LMWC increased the activity of key proteins involved in insulin signaling in these organs through the AKT/PI3K/FOXO pathway, enhancing insulin secretion and improving glucose metabolism in T1DM rats. This contributed to improved hepatic glycogen synthesis and suppression of gluconeogenesis in T1DM rats. In summary, LMWC could be an effective antidiabetic supplement, offering insights into dietary treatment for diabetes management.
C1 [Priyanka, D. N.; Prashanth, K. V. Harish] CSIR Cent Food Technol Res Inst, Dept Biochem, Funct Biopolymer Lab, Mysuru 570020, Karnataka, India.
C3 Council of Scientific & Industrial Research (CSIR) - India; CSIR -
   Central Food Technological Research Institute (CFTRI)
RP Prashanth, KVH (corresponding author), CSIR Cent Food Technol Res Inst, Dept Biochem, Funct Biopolymer Lab, Mysuru 570020, Karnataka, India.
EM harish@cftri.res.in
RI Prashanth, Harish/C-1706-2010
FU Council of Scientific and Industrial Research (CSIR) , New Delhi
   [31/005(0578)/2019-EMR-I]
FX Author Ms. D.N. Priyanka greatly acknowledges the Council of Scientific
   and Industrial Research (CSIR) , New Delhi for Junior/Senior Research
   Fellowship (31/005(0578)/2019-EMR-I) . The authors wish to thank the
   Director, CSIR-CFTRI for the interest and encouragement.
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NR 67
TC 1
Z9 1
U1 1
U2 2
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2666-8939
J9 CARBOHYDR POLYM TECH
JI Carbohydr. Polym. Technol. Appl.
PD DEC
PY 2024
VL 8
AR 100534
DI 10.1016/j.carpta.2024.100534
EA JUN 2024
PG 14
WC Chemistry, Applied; Polymer Science
WE Emerging Sources Citation Index (ESCI)
SC Chemistry; Polymer Science
GA L9F0S
UT WOS:001353695700001
OA gold
DA 2025-06-11
ER

PT J
AU La Colla, A
   Cámara, CA
   Campisano, S
   Chisari, AN
AF La Colla, Anabela
   Anahi Camara, Carolina
   Campisano, Sabrina
   Nancy Chisari, Andrea
TI Mitochondrial dysfunction and epigenetics underlying the link between
   early-life nutrition and non-alcoholic fatty liver disease
SO NUTRITION RESEARCH REVIEWS
LA English
DT Review
DE Early-life nutrition; Epigenetics; Mitochondria; Developmental
   programming; NAFLD
ID PROLIFERATOR-ACTIVATED RECEPTOR; MATERNAL PROTEIN RESTRICTION;
   DYNAMIN-RELATED PROTEIN; INSULIN-RESISTANCE; GENE-EXPRESSION;
   DEVELOPMENTAL ORIGINS; METABOLIC-SYNDROME; OXIDATIVE STRESS;
   TRANSCRIPTIONAL CONTROL; HEPATIC STEATOSIS
AB Early-life malnutrition plays a critical role in foetal development and predisposes to metabolic diseases later in life, according to the concept of 'developmental programming'. Different types of early nutritional imbalance, including undernutrition, overnutrition and micronutrient deficiency, have been related to long-term metabolic disorders. Accumulating evidence has demonstrated that disturbances in nutrition during the period of preconception, pregnancy and primary infancy can affect mitochondrial function and epigenetic mechanisms. Moreover, even though multiple mechanisms underlying non-alcoholic fatty liver disease (NAFLD) have been described, in the past years, special attention has been given to mitochondrial dysfunction and epigenetic alterations. Mitochondria play a key role in cellular metabolic functions. Dysfunctional mitochondria contribute to oxidative stress, insulin resistance and inflammation. Epigenetic mechanisms have been related to alterations in genes involved in lipid metabolism, fibrogenesis, inflammation and tumorigenesis. In accordance, studies have reported that mitochondrial dysfunction and epigenetics linked to early-life nutrition can be important contributing factors in the pathogenesis of NAFLD. In this review, we summarise the current understanding of the interplay between mitochondrial dysfunction, epigenetics and nutrition during early life, which is relevant to developmental programming of NAFLD.
C1 [La Colla, Anabela; Anahi Camara, Carolina; Campisano, Sabrina; Nancy Chisari, Andrea] Univ Nacl Mar del Plata, Fac Ciencias Exactas & Nat, Dept Quim & Bioquim, RA-7600 Mar Del Plata, Argentina.
C3 National University of Mar del Plata
RP La Colla, A; Chisari, AN (corresponding author), Univ Nacl Mar del Plata, Fac Ciencias Exactas & Nat, Dept Quim & Bioquim, RA-7600 Mar Del Plata, Argentina.
EM achisari@mdp.edu.ar; analacolla@mdp.edu.ar
OI Chisari, Andrea/0000-0001-9351-0138
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NR 135
TC 8
Z9 8
U1 3
U2 13
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0954-4224
EI 1475-2700
J9 NUTR RES REV
JI Nutr. Res. Rev.
PD DEC
PY 2023
VL 36
IS 2
BP 281
EP 294
AR PII S0954422422000038
DI 10.1017/S0954422422000038
EA JAN 2022
PG 14
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA JH8H6
UT WOS:000950350800001
PM 35067233
DA 2025-06-11
ER

PT J
AU Kramer, BL
   Himmelstein, MS
   Springer, KW
AF Kramer, Brandon L.
   Himmelstein, Mary S.
   Springer, Kristen W.
TI Getting to the Heart of Masculinity Stressors: Masculinity Threats
   Induce Pronounced Vagal Withdrawal During a Speaking Task
SO ANNALS OF BEHAVIORAL MEDICINE
LA English
DT Article
DE Stress; Masculinity; Men's health; Heart rate variability; Vagal
   withdrawal
ID METABOLIC SYNDROME; RATE-VARIABILITY; SEX-DIFFERENCES; CARDIOVASCULAR
   REACTIVITY; PHYSIOLOGICAL-RESPONSES; ALLOSTATIC LOAD; UNITED-STATES;
   GENDER; INTEGRATION; MECHANISMS
AB Previous work has found that traditional masculinity ideals and behaviors play a crucial role in higher rates of morbidity and mortality for men. Some studies also suggest that threatening men's masculinity can be stressful. Over time, this stress can weigh on men's cardiovascular and metabolic systems, which may contribute to men's higher rates of cardiometabolic health issues.
   The purpose of this study is to explore how masculinity threats affect men's heart rate and heart rate variability reactivity (i.e., vagal withdrawal) to masculinity feedback on a social speaking task.
   Two hundred and eighty-five undergraduate males were randomly assigned to one of six conditions during a laboratory-based speech task. They received one of two feedback types (masculinity or control) and one of three feedback levels (low, high, or dropping) in order to assess whether masculinity threats influence heart rate reactivity and vagal withdrawal patterns during the speech task.
   Men who receive low masculinity feedback during the speech task experienced more pronounced vagal withdrawal relative to those who received the control.
   Masculinity threats can induce vagal withdrawal that may accumulate over the life course to contribute to men's relatively worse cardiometabolic health.
C1 [Kramer, Brandon L.; Springer, Kristen W.] Rutgers State Univ, Dept Sociol, New Brunswick, NJ 08901 USA.
   [Kramer, Brandon L.; Himmelstein, Mary S.; Springer, Kristen W.] Rutgers State Univ, Inst Hlth Hlth Care Policy & Aging Res, New Brunswick, NJ 08901 USA.
   [Himmelstein, Mary S.] Rutgers State Univ, Dept Psychol, New Brunswick, NJ USA.
   [Himmelstein, Mary S.] Univ Connecticut, Rudd Ctr Food Policy & Obes, Hartford, CT 06112 USA.
C3 Rutgers University System; Rutgers University New Brunswick; Rutgers
   University System; Rutgers University New Brunswick; Rutgers University
   System; Rutgers University New Brunswick; University of Connecticut
RP Springer, KW (corresponding author), Rutgers State Univ, Dept Sociol, New Brunswick, NJ 08901 USA.; Springer, KW (corresponding author), Rutgers State Univ, Inst Hlth Hlth Care Policy & Aging Res, New Brunswick, NJ 08901 USA.
EM kspringe@rci.rutgers.edu
OI Kramer, Brandon/0000-0002-3233-5310; Himmelstein,
   Mary/0000-0002-3173-1901
FU Rutgers University
FX This study was partly supported by a Rutgers University Busch Biomedical
   Grant to Kristen W. Springer. We thank our undergraduate research team
   for their assistance in collecting the data and preparing the data set.
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NR 48
TC 9
Z9 14
U1 0
U2 6
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0883-6612
EI 1532-4796
J9 ANN BEHAV MED
JI Ann. Behav. Med.
PD DEC
PY 2017
VL 51
IS 6
BP 846
EP 855
DI 10.1007/s12160-017-9907-z
PG 10
WC Psychology, Multidisciplinary
WE Social Science Citation Index (SSCI)
SC Psychology
GA FJ4SY
UT WOS:000412733700006
PM 28401414
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Briones, AM
   Aras-López, R
   Alonso, MJ
   Salaices, M
AF Briones, Ana M.
   Aras-Lopez, Rosa
   Alonso, Maria J.
   Salaices, Mercedes
TI Small Artery Remodeling in Obesity and Insulin Resistance
SO CURRENT VASCULAR PHARMACOLOGY
LA English
DT Article
DE Obesity; insulin resistance; remodeling; small arteries; stiffness
ID RENIN-ANGIOTENSIN SYSTEM; PERIVASCULAR ADIPOSE-TISSUE; SUBCUTANEOUS
   SMALL ARTERIES; CARDIOVASCULAR RISK-FACTORS; TYPE-2 DIABETES-MELLITUS;
   METABOLIC SYNDROME; BLOOD-PRESSURE; WEIGHT-LOSS; OXIDATIVE STRESS;
   MICROVASCULAR DYSFUNCTION
AB Microvascular abnormalities, both in function and structure, lead to impaired tissue perfusion that may affect multiple tissues and organs and seem to be involved in target-organ damage and complications observed in obesity and insulin resistance. In general, vascular remodeling of small arteries associated to cardiometabolic diseases seems to be hypertrophic and it is associated to increased extracellular matrix deposition, although specific vascular beds might show different structural patterns. The mechanisms by which obesity, insulin resistance and/or hyperinsulimemia determine vascular disease are not clear yet but might include hemodynamic factors such as hypertension, activation of the sympathetic nervous and the renin-angiotensin-aldosterone systems, metabolic factors such as insulin and advanced glycation end products and other factors such as adipokines, inflammation or oxidative stress. Exercise and weight loss as well as blockade of the renin-angiotensin system seem to be efficient actions to correct vascular alterations in patients. This review aims to examine the existing literature on structural alterations in small vessels associated to insulin resistance and obesity. A description about the underlying mechanisms possibly responsible of the vascular alterations is also provided. Moreover, effects of pharmacological and non pharmacological strategies that could modify these vascular alterations are summarized.
C1 [Briones, Ana M.; Aras-Lopez, Rosa; Alonso, Maria J.; Salaices, Mercedes] Univ Autonoma Madrid, Fac Med, Dept Farmacol, Inst Invest Hosp Univ La Paz IdiPAZ, E-28029 Madrid, Spain.
C3 Autonomous University of Madrid; Hospital Universitario La Paz
RP Briones, AM (corresponding author), Univ Autonoma Madrid, Fac Med, Dept Farmacol, Arzobispo Morcillo 4, E-28029 Madrid, Spain.
EM ana.briones@uam.es; mercedes.salaices@uam.es
RI Alonso, María/AAB-4309-2019
OI Salaices Sanchez, Mercedes/0000-0003-3323-1692; Alonso, Maria
   Jesus/0000-0003-4912-1121; Aras, Rosa Maria/0000-0001-9000-1821;
   Briones, Ana/0000-0001-8218-5579
FU Ministerio de Economia y Competitividad [SAF2009-07201, SAF2012-36400];
   Instituto de Salud Carlos III [RD06/0014/0011, RD12/0042/0024]; Ramon y
   Cajal Program [RYC-2010-06473]; Juan de la Cierva Program
   [JCI-2010-08020]; Fundacion Mutua Madrilena; Fundacion Mapfre
FX Studies performed by the authors were supported by grants from
   Ministerio de Economia y Competitividad (SAF2009-07201, SAF2012-36400),
   Instituto de Salud Carlos III (Red RECAVA, RD06/0014/0011, Retic
   Enfermedades Cardiovasculares RD12/0042/0024), Fundacion Mutua Madrilena
   and Fundacion Mapfre. AMB is supported through the Ramon y Cajal Program
   (RYC-2010-06473) and RAL by the Juan de la Cierva Program
   (JCI-2010-08020).
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NR 144
TC 24
Z9 27
U1 0
U2 17
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1570-1611
EI 1875-6212
J9 CURR VASC PHARMACOL
JI Current Vascular Pharmacology
PY 2014
VL 12
IS 3
BP 427
EP 437
DI 10.2174/1570161112666140423221319
PG 11
WC Pharmacology & Pharmacy; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Cardiovascular System & Cardiology
GA AW4UI
UT WOS:000346275400010
PM 24846232
DA 2025-06-11
ER

PT J
AU Eng, QY
   Thanikachalam, PV
   Ramamurthy, S
AF Eng, Qian Yi
   Thanikachalam, Punniyakoti Veeraveedu
   Ramamurthy, Srinivasan
TI Molecular understanding of Epigallocatechin gallate (EGCG) in
   cardiovascular and metabolic diseases
SO JOURNAL OF ETHNOPHARMACOLOGY
LA English
DT Review
DE EGCG; Diabetes; Atherosclerosis; Antioxidant; Heart failure;
   Anti-inflammatory
ID GREEN-TEA POLYPHENOL; CARDIOMETABOLIC RISK-FACTORS; (-)-EPIGALLOCATECHIN
   GALLATE; ANTIOXIDANT ACTIVITY; IN-VITRO; DIETARY SUPPLEMENTATION;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; ADIPOSE-TISSUE; UP-REGULATION
AB Ethnopharmacological relevance: The compound epigallocatechin-3-gallate (EGCG), the major polyphenolic compound present in green tea [Camellia sinensis (Theaceae], has shown numerous cardiovascular health promoting activity through modulating various pathways. However, molecular understanding of the cardiovascular protective role of EGCG has not been reported.
   Aim of the review: This review aims to compile the preclinical and clinical studies that had been done on EGCG to investigate its protective effect on cardiovascular and metabolic diseases in order to provide a systematic guidance for future research.
   Materials and methods: Research papers related to EGCG were obtained from the major scientific databases, for example, Science direct, PubMed, NCBI, Springer and Google scholar, from 1995 to 2017.
   Results: EGCG was found to exhibit a wide range of therapeutic properties including anti-atherosclerosis, anti cardiac hypertrophy, anti-myocardial infarction, anti-diabetes, anti-inflammatory and antioxidant. These therapeutic effects are mainly associated with the inhibition of LDL cholesterol (anti-atherosclerosis), inhibition of NE-kappa B (anti-cardiac hypertrophy), inhibition of MPO activity (anti-myocardial infarction), reduction in plasma glucose and glycated haemoglobin level (anti-diabetes), reduction of inflammatory markers (anti-inflammatory) and the inhibition of ROS generation (antioxidant).
   Conclusion: EGCG shows different biological activities and in this review, a compilation of how this bioactive molecule plays its role in treating cardiovascular and metabolic diseases was discussed.
C1 [Eng, Qian Yi; Thanikachalam, Punniyakoti Veeraveedu; Ramamurthy, Srinivasan] Int Med Univ, Sch Pharm, Dept Pharmaceut Chem, Bukit Jalil 57000, Malaysia.
C3 International Medical University Malaysia
RP Ramamurthy, S (corresponding author), Int Med Univ, Sch Pharm, Dept Pharmaceut Chem, Bukit Jalil 57000, Malaysia.
EM srinivasan_ramamurthy@imu.edu.my
RI THANIKACHALAM, PUNNIYAKOTI/JFS-2157-2023
OI Ramamurthy, Srinivasan/0000-0002-8434-151X
FU BSc. (Hons) Pharmaceutical chemistry programme, School of Pharmacy,
   International medical university, Malaysia
FX This work was supported by BSc. (Hons) Pharmaceutical chemistry
   programme, School of Pharmacy, International medical university,
   Malaysia.
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NR 125
TC 208
Z9 217
U1 20
U2 218
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0378-8741
EI 1872-7573
J9 J ETHNOPHARMACOL
JI J. Ethnopharmacol.
PD JAN 10
PY 2018
VL 210
BP 296
EP 310
DI 10.1016/j.jep.2017.08.035
PG 15
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA FO5FN
UT WOS:000416879000027
PM 28864169
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Liang, YQ
   Lang, AL
   Zhang, J
   Chen, J
   Wang, K
   Chen, LY
   Beier, J
   Qian, Y
   Cai, L
AF Liang, Yaqin
   Lang, Anna L.
   Zhang, Jian
   Chen, Jing
   Wang, Kai
   Chen, Liya
   Beier, Juliane, I
   Qian, Yan
   Cai, Lu
TI Exposure to Vinyl Chloride and Its Influence on Western Diet-Induced
   Cardiac Remodeling
SO CHEMICAL RESEARCH IN TOXICOLOGY
LA English
DT Article
ID PLASMINOGEN-ACTIVATOR INHIBITOR-1; GROWTH-FACTOR-BETA; NF-KAPPA-B;
   OXIDATIVE STRESS; HIGH-FAT; METABOLIC SYNDROME; LIVER-INJURY; OBESITY;
   HEART; DYSFUNCTION
AB Obesity, usually caused by high fat diets (HFD), is a major public health issue worldwide, causing obesity associated cardiomyopathy. Moreover, the environmental toxicant vinyl chloride (VC) can exacerbate HFD-induced fatty liver disease. However, whether VC serves to enhance obesity-associated cardiomyopathy remains unclear. This study aims to investigate the interaction of western diet (WD) containing relatively low fat (42%) with VC on cardiac remodeling and its underling mechanisms. Adult male C57BL/6J mice were exposed to WD coinhalation of low-dose VC (<1 ppm/d) for 12 weeks. Results showed that WD feeding for 12 weeks caused slight cardiac systolic dysfunction without significant hypertrophy or fibrosis, even with VC. Nevertheless, WD upregulated NF-kappa B function and expression of IL-1 beta and PAI-1, while VC showed no significant impact on these effects. In contrast, WD together with VC significantly increased the expression of CHOP and TGF-beta 1, key markers for endoplasmic reticulum stress and profibrotic cytokine, respectively. In summary, exposure to low-dose of environmental toxicant VC while a WD is consumed for a relatively short time does not have significant impact on cardiac remodeling except for a mild systolic dysfunction of the heart.
C1 [Liang, Yaqin; Wang, Kai; Qian, Yan] Wenzhou Med Univ, Affiliated Hosp 1, Dept Pediat, Wenzhou 325000, Peoples R China.
   [Liang, Yaqin; Zhang, Jian; Chen, Jing; Wang, Kai; Cai, Lu] Univ Louisville, Alcohol Res Ctr, Dept Pediat, Pediat Res Inst, Louisville, KY 40292 USA.
   [Lang, Anna L.; Chen, Liya; Beier, Juliane, I; Cai, Lu] Univ Louisville, Alcohol Res Ctr, Dept Pharmacol & Toxicol, Louisville, KY 40292 USA.
   [Lang, Anna L.; Chen, Liya; Beier, Juliane, I] Univ Louisville, Alcohol Res Ctr, Hepatobiol & Toxicol Program, Louisville, KY 40292 USA.
   [Zhang, Jian; Cai, Lu] Jilin Univ, Hosp 1, Ctr Cardiovasc Disorders, Changchun 130021, Jilin, Peoples R China.
C3 Wenzhou Medical University; University of Louisville; University of
   Louisville; University of Louisville; Jilin University
RP Qian, Y (corresponding author), Wenzhou Med Univ, Affiliated Hosp 1, Dept Pediat, Wenzhou 325000, Peoples R China.; Beier, J (corresponding author), Univ Louisville, Alcohol Res Ctr, Dept Pharmacol & Toxicol, Louisville, KY 40292 USA.; Beier, J (corresponding author), Univ Louisville, Alcohol Res Ctr, Hepatobiol & Toxicol Program, Louisville, KY 40292 USA.
EM qianyan11@126.com
RI Cai, Lu/AAG-9920-2019
OI Liang, Yaqin/0000-0002-3714-7351
FU National Institutes of Health [K01 DK096042, R03 DK107912]; National
   Institute of General Medical Sciences of the National Institutes of
   Health [P20GM113226, P20 GM10349]; National Institute on Alcohol Abuse
   and Alcoholism of the National Institutes of Health [P50AA024337];
   National Institute of Environmental Health Sciences [P42 ES023716]
FX National Institutes of Health: K01 DK096042, R03 DK107912 to J.I.B.
   J.I.B. was also supported by Institutional Development Awards (IDeA)
   from the National Institute of General Medical Sciences of the National
   Institutes of Health under Grant No. P20GM113226, P20 GM10349, the
   National Institute on Alcohol Abuse and Alcoholism of the National
   Institutes of Health under Award No. P50AA024337, and the National
   Institute of Environmental Health Sciences under Award No. P42 ES023716.
   The content is solely the responsibility of the authors and does not
   necessarily represent the official views of the National Institutes of
   Health.
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NR 47
TC 12
Z9 12
U1 1
U2 8
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0893-228X
EI 1520-5010
J9 CHEM RES TOXICOL
JI Chem. Res. Toxicol.
PD JUN
PY 2018
VL 31
IS 6
BP 482
EP 493
DI 10.1021/acs.chemrestox.8b00043
PG 12
WC Chemistry, Medicinal; Chemistry, Multidisciplinary; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Chemistry; Toxicology
GA GK3GJ
UT WOS:000436030100009
PM 29727174
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Pruimboom, L
   Raison, CL
   Muskiet, FAJ
AF Pruimboom, Leo
   Raison, Charles L.
   Muskiet, Frits A. J.
TI Physical Activity Protects the Human Brain against Metabolic Stress
   Induced by a Postprandial and Chronic Inflammation
SO BEHAVIOURAL NEUROLOGY
LA English
DT Review
ID LOW-GRADE INFLAMMATION; ENDOGENOUS MORPHINE; IMMUNE-SYSTEM; LIFE-STYLE;
   ECCENTRIC EXERCISE; GLUCOSE-METABOLISM; OXIDATIVE STRESS;
   SKELETAL-MUSCLE; BODY-SIZE; EVOLUTION
AB In recent years, it has become clear that chronic systemic low-grade inflammation is at the root of many, if not all, typically Western diseases associated with the metabolic syndrome. While much focus has been given to sedentary lifestyle as a cause of chronic inflammation, it is less often appreciated that chronic inflammation may also promote a sedentary lifestyle, which in turn causes chronic inflammation. Given that even minor increases in chronic inflammation reduce brain volume in otherwise healthy individuals, the bidirectional relationship between inflammation and sedentary behaviour may explain why humans have lost brain volume in the last 30,000 years and also intelligence in the last 30 years. We review evidence that lack of physical activity induces chronic low-grade inflammation and, consequently, an energy conflict between the selfish immune system and the selfish brain. Although the notion that increased physical activity would improve health in the modern world is widespread, here we provide a novel perspective on this truism by providing evidence that recovery of normal human behaviour, such as spontaneous physical activity, would calm proinflammatory activity, thereby allocating more energy to the brain and other organs, and by doing so would improve human health.
C1 [Pruimboom, Leo] Nat Fdn, NL-3281 NC Numansdorp, Netherlands.
   [Pruimboom, Leo; Muskiet, Frits A. J.] Univ Groningen, Univ Med Ctr Groningen, Dept Lab Med, NL-9700 RB Groningen, Netherlands.
   [Raison, Charles L.] Univ Arizona, Coll Med, Dept Psychiat, Tucson, AZ USA.
   [Raison, Charles L.] Univ Arizona, Coll Agr & Life Sci, Norton Sch Family & Consumer Sci, Tucson, AZ USA.
C3 University of Groningen; University of Arizona; University of Arizona
RP Pruimboom, L (corresponding author), Nat Fdn, Edisonstr 66, NL-3281 NC Numansdorp, Netherlands.
EM cpni.pruimboom@icloud.com
RI Raison, Charles/N-6972-2018
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NR 130
TC 21
Z9 23
U1 0
U2 16
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 0953-4180
EI 1875-8584
J9 BEHAV NEUROL
JI Behav. Neurol.
PY 2015
VL 2015
AR 569869
DI 10.1155/2015/569869
PG 11
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA CI4EP
UT WOS:000354700200001
PM 26074674
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU O'Keefe, JH
   Gheewala, NM
   O'Keefe, JO
AF O'Keefe, James H.
   Gheewala, Neil M.
   O'Keefe, Joan O.
TI Dietary strategies for improving post-prandial glucose, lipids,
   inflammation, and cardiovascular health
SO JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
LA English
DT Article
ID C-REACTIVE PROTEIN; METABOLIC SYNDROME; DIABETES-MELLITUS; OXIDATIVE
   STRESS; BLOOD-GLUCOSE; US POPULATION; RISK-FACTOR; WOMEN; DISEASE;
   TOLERANCE
AB The highly processed, calorie-dense, nutrient-depleted diet favored in the current American culture frequently leads to exaggerated supraphysiological post-prandial spikes in blood glucose and lipids. This state, called postprandial dysmetabolism, induces immediate oxidant stress, which increases in direct proportion to the increases in glucose and triglycericles after a meal. The transient increase in free radicals acutely triggers atherogenic changes including inflammation, endothelial dysfunction, hypercoagulability, and sympathetic hyperactivity. Post-prandial dysmetabolism is an independent predictor of future cardiovascular events even in nondiabetic individuals. Improvements in diet exert profound and immediate favorable changes in the post-prandial dysmetabolism. Specifically, a diet high in minimally processed, high-fiber, plant-based foods such as vegetables and fruits, whole grains, legumes, and nuts will markedly blunt the post-meal increase in glucose, triglycerides, and inflammation. Additionally, lean protein, vinegar, fish oil, tea, cinnamon, calorie restriction, weight loss, exercise, and low-dose to moderate-dose alcohol each positively impact post-prandial dysmetabolism. Experimental and epidemiological studies indicate that eating patterns, such as the traditional Mediterranean or Okinawan diets, that incorporate these types of foods and beverages reduce inflammation and cardiovascular risk. This anti-inflammatory diet should be considered for the primary and secondary prevention of coronary artery disease and diabetes.
C1 [O'Keefe, James H.; Gheewala, Neil M.; O'Keefe, Joan O.] St Lukes Hosp, Mid Amer Heart Inst, Kansas City, MO 64111 USA.
   [O'Keefe, James H.; Gheewala, Neil M.; O'Keefe, Joan O.] Univ Missouri, Kansas City, MO 64110 USA.
C3 Saint Luke's Hospital - Missouri; Saint Luke's Mid America Heart
   Institute; University of Missouri System; University of Missouri Kansas
   City
RP O'Keefe, JH (corresponding author), 4330 Wornall Rd,Suite 2000, Kansas City, MO 64111 USA.
EM jhokeefe@cc-pc.com
OI O'Keefe, James/0000-0002-3376-5822
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NR 41
TC 370
Z9 404
U1 0
U2 69
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0735-1097
EI 1558-3597
J9 J AM COLL CARDIOL
JI J. Am. Coll. Cardiol.
PD JAN 22
PY 2008
VL 51
IS 3
BP 249
EP 255
DI 10.1016/j.jacc.2007.10.016
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 254DD
UT WOS:000252565700001
PM 18206731
OA Bronze
DA 2025-06-11
ER

PT J
AU Altamura, S
   Pietropaoli, D
   Lombardi, F
   Del Pinto, R
   Ferri, C
AF Altamura, Serena
   Pietropaoli, Davide
   Lombardi, Francesca
   Del Pinto, Rita
   Ferri, Claudio
TI An Overview of Chronic Kidney Disease Pathophysiology: The Impact of Gut
   Dysbiosis and Oral Disease
SO BIOMEDICINES
LA English
DT Review
DE chronic kidney disease; inflammation; uremic toxins; gut dysbiosis; oral
   disease; microbiota; probiotics
ID TRIMETHYLAMINE-N-OXIDE; STAGE RENAL-DISEASE; NONSURGICAL PERIODONTAL
   THERAPY; P-CRESYL SULFATE; BODY-MASS INDEX; OXIDATIVE STRESS;
   CARDIOVASCULAR RISK; METABOLIC-ACIDOSIS; INNATE IMMUNITY; UREMIC TOXINS
AB Chronic kidney disease (CKD) is a severe condition and a significant public health issue worldwide, carrying the burden of an increased risk of cardiovascular events and mortality. The traditional factors that promote the onset and progression of CKD are cardiometabolic risk factors like hypertension and diabetes, but non-traditional contributors are escalating. Moreover, gut dysbiosis, inflammation, and an impaired immune response are emerging as crucial mechanisms in the disease pathology. The gut microbiome and kidney disease exert a reciprocal influence commonly referred to as "the gut-kidney axis" through the induction of metabolic, immunological, and endocrine alterations. Periodontal diseases are strictly involved in the gut-kidney axis for their impact on the gut microbiota composition and for the metabolic and immunological alterations occurring in and reciprocally affecting both conditions. This review aims to provide an overview of the dynamic biological interconnections between oral health status, gut, and renal pathophysiology, spotlighting the dynamic oral-gut-kidney axis and raising whether periodontal diseases and gut microbiota can be disease modifiers in CKD. By doing so, we try to offer new insights into therapeutic strategies that may enhance the clinical trajectory of CKD patients, ultimately advancing our quest for improved patient outcomes and well-being.
C1 [Altamura, Serena; Pietropaoli, Davide; Del Pinto, Rita; Ferri, Claudio] Univ Aquila, Dept Life Hlth & Environm Sci, I-67100 Laquila, Italy.
   [Altamura, Serena] Ctr Oral Dis Prevent & Translat Res Dent Clin, PhD Sch Med & Publ Hlth, I-67100 Laquila, Italy.
   [Altamura, Serena; Pietropaoli, Davide; Del Pinto, Rita; Ferri, Claudio] Oral Dis & Syst Interact Study Grp, ODISSY Grp, I-67100 Laquila, Italy.
   [Pietropaoli, Davide] Ctr Oral Dis Prevent & Translat Res Dent Clin, I-67100 Laquila, Italy.
   [Lombardi, Francesca] Univ LAquila, Dept Life Hlth & Environm Sci, Lab Immunol & Immunopathol, I-67100 Laquila, Italy.
   [Del Pinto, Rita; Ferri, Claudio] San Salvatore Hosp, Ctr Hypertens & Cardiovasc Prevent, Unit Internal Med & Nephrol, I-67100 Laquila, Italy.
C3 University of L'Aquila; University of L'Aquila
RP Del Pinto, R (corresponding author), Univ Aquila, Dept Life Hlth & Environm Sci, I-67100 Laquila, Italy.; Del Pinto, R (corresponding author), Oral Dis & Syst Interact Study Grp, ODISSY Grp, I-67100 Laquila, Italy.; Del Pinto, R (corresponding author), San Salvatore Hosp, Ctr Hypertens & Cardiovasc Prevent, Unit Internal Med & Nephrol, I-67100 Laquila, Italy.
EM serena.altamura@graduate.univaq.it; davide.pietropaoli@univaq.it;
   rancesca.lombardi@univaq.it; rita.delpinto@univaq.it;
   claudio.ferri@univaq.it
RI Altamura, Serena/MDT-6066-2025; Pietropaoli, Davide/V-6668-2019
OI Altamura, Serena/0000-0001-7146-3852; Pietropaoli,
   Davide/0000-0001-9585-1809; Ferri, Claudio/0000-0002-3594-2503
FU National Institutes of Health
FX No Statement Available
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NR 286
TC 16
Z9 17
U1 4
U2 13
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2227-9059
J9 BIOMEDICINES
JI Biomedicines
PD NOV
PY 2023
VL 11
IS 11
AR 3033
DI 10.3390/biomedicines11113033
PG 29
WC Biochemistry & Molecular Biology; Medicine, Research & Experimental;
   Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Research & Experimental Medicine;
   Pharmacology & Pharmacy
GA Z9PR8
UT WOS:001115332600001
PM 38002033
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Graf, S
   Khorsand, A
   Gwechenberger, M
   Schütz, M
   Kletter, K
   Sochor, H
   Dudczak, R
   Maurer, G
   Pirich, C
   Porenta, G
   Zehetgruber, M
AF Graf, S
   Khorsand, A
   Gwechenberger, M
   Schütz, M
   Kletter, K
   Sochor, H
   Dudczak, R
   Maurer, G
   Pirich, C
   Porenta, G
   Zehetgruber, M
TI Myocardial perfusion in patients with typical chest pain and normal
   angiogram
SO EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
LA English
DT Article
DE coronary flow reserve; microvascular disease; positron emission
   tomography
ID CORONARY FLOW RESERVE; POSITRON EMISSION TOMOGRAPHY; CONVERTING
   ENZYME-INHIBITION; ST SEGMENT DEPRESSION; SYNDROME-X; BLOOD-FLOW;
   ENDOTHELIAL DYSFUNCTION; ANGINA-PECTORIS; N-13 AMMONIA; ARTERY DISEASE
AB Background Approximately 10-30% of patients with typical chest pain present normal epicardial coronaries. In a proportion of these patients, angina is attributed to microvascular dysfunction. Previous studies investigating whether angina is the result of abnormal resting or stress perfusion are controversial but limited by varying inclusion criteria. Therefore, we investigated whether microvascular dysfunction in these patients is associated with perfusion abnormalities at rest or at stress.
   Patients and methods In 58 patients (39 female, 19 male, mean age 58 +/- 10 years) with angina and normal angiogram as well as 10 control patients with atypical chest pain and normal coronaries (six female, four male, mean age 53 +/- 11 years) myocardial blood flow (MBF) was measured at rest and under dipyridamole using N-13-ammonia PET. Resting MBF and coronary flow reserve (CFR) as the ratio of hyperaemic to resting MBF were corrected for rate - pressure - product (RPP): normalized resting MBF (MBFn) = MBF x 10 000/RPP and CFRn = CFR x RPP/10 000.
   Results Sixteen/58 patients had a normal CFRn (= 2.5; group I; CFRn: 3.1 +/- 0.88); the same as the controls (CFRn: 3.3 +/- 0.74). Forty-two/58 patients presented a reduced CFRn (group II; CFRn: 1.78 +/- 0.57). Group II had both a higher MBFn (group II: 1.30 +/- 0.33 vs. Group I: 1.03 +/- 0.26; P < 0.05 and vs. controls: 1.07 +/- 0.19; P < 0.01) and a lower hyperaemic MBF (group II: 2.25 +/- 0.76 mL g(-1) min(-1) vs. Group I: 3.07 +/- 0.78 mL g(-1) min(-1); P < 0.001 and vs. controls: 3.41 +/- 0.94 mL g(-1) min(-1); P < 0.0001).
   Conclusion Impaired CFRn in patients with typical angina and normal angiogram is owing to both an increased resting and reduced hyperaemic MBF. Therefore, PET represents a prerequisite for further studies to optimize treatment in individuals with anginal pain and normal coronary angiogram.
C1 Med Univ Vienna, Dept Cardiol, A-1090 Vienna, Austria.
   Med Univ Vienna, Dept Nucl Med, A-1090 Vienna, Austria.
   Private Med Univ Salzburg, Dept Nucl Med, Salzburg, Austria.
   Dept Nucl Med, Vienna, Austria.
C3 Medical University of Vienna; Medical University of Vienna
RP Graf, S (corresponding author), Med Univ Vienna, Dept Cardiol, Waehringer Guertel 18-20, A-1090 Vienna, Austria.
EM senta.graf@meduniwien.ac.at
RI Pirich, Christian/AAS-6035-2020
OI Pirich, Christian/0000-0002-4502-0609; Maurer,
   Gerald/0000-0002-9043-7657
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NR 45
TC 19
Z9 19
U1 0
U2 5
PU BLACKWELL PUBLISHING
PI OXFORD
PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND
SN 0014-2972
J9 EUR J CLIN INVEST
JI Eur. J. Clin. Invest.
PD MAY
PY 2006
VL 36
IS 5
BP 326
EP 332
DI 10.1111/j.1365-2362.2006.01635.x
PG 7
WC Medicine, General & Internal; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Research & Experimental Medicine
GA 032HZ
UT WOS:000236766800005
PM 16634836
DA 2025-06-11
ER

PT J
AU Jiménez, MDFF
AF Jimenez, Mariana del Carmen Fernandez-Figares
TI Plant foods, healthy plant-based diets, and type 2 diabetes: a review of
   the evidence
SO NUTRITION REVIEWS
LA English
DT Review
DE healthy plant-based diet; plant-based diet; plant protein; type 2
   diabetes; vegan diet
ID GLYCATION END-PRODUCTS; MUSCLE INSULIN-RESISTANCE; CHAIN AMINO-ACIDS;
   HIGH-FAT DIET; CARDIOMETABOLIC RISK-FACTORS; RED MEAT CONSUMPTION;
   BRANCHED-CHAIN; LIFE-STYLE; OXIDATIVE STRESS; ADVENTIST-HEALTH
AB Type 2 diabetes (T2D) is a metabolic chronic disease in which insulin resistance and insufficient insulin production lead to elevated blood glucose levels. The prevalence of T2D is growing worldwide, mainly due to obesity and the adoption of Western diets. Replacing animal foods with healthy plant foods is associated with a lower risk of T2D in prospective studies. In randomized controlled trials, the consumption of healthy plant foods in place of animal foods led to cardiometabolic improvements in patients with T2D or who were at high risk of the disease. Dietary patterns that limit or exclude animal foods and focus on healthy plant foods (eg, fruits, vegetables, whole grains, nuts, legumes), known as healthy, plant-based diets, are consistently associated with a lower risk of T2D in cohort studies. The aim of this review is to examine the differential effects of plant foods and animal foods on T2D risk and to describe the existing literature about the role of healthy, plant-based diets, particularly healthy vegan diets, in T2D prevention and management. The evidence from cohort studies and randomized controlled trials will be reported, in addition to the potential biological mechanisms that seem to be involved.
C1 [Jimenez, Mariana del Carmen Fernandez-Figares] Univ Granada, Sch Med, Granada, Spain.
   [Jimenez, Mariana del Carmen Fernandez-Figares] Univ Granada, Fac Med, Granada 18071, Spain.
C3 University of Granada; University of Granada
RP Jiménez, MDFF (corresponding author), Univ Granada, Fac Med, Granada 18071, Spain.
EM mariana2002.ffj@gmail.com
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NR 233
TC 5
Z9 5
U1 4
U2 32
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0029-6643
EI 1753-4887
J9 NUTR REV
JI Nutr. Rev.
PD AUG 7
PY 2023
VL 82
IS 7
BP 929
EP 948
DI 10.1093/nutrit/nuad099
EA AUG 2023
PG 20
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA TN0X9
UT WOS:001042301900001
PM 37550262
DA 2025-06-11
ER

PT J
AU Frisbee, JC
AF Frisbee, JC
TI Remodeling of the skeletal muscle microcirculation increases resistance
   to perfusion in obese Zucker rats
SO AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
LA English
DT Article
DE microvessel rarefaction; vascular wall mechanics; passive vascular
   mechanics; models of syndrome X; obesity; diabetes mellitus
ID MICROVASCULAR RAREFACTION; STRUCTURAL-CHANGES; HYPERTENSION; GENE;
   ARTERIOLES; ACTIVATION; DILATION; MODEL
AB Whereas previous studies have demonstrated that the development of syndrome X in obese Zucker rats (OZR) is associated with impaired arteriolar reactivity to vasoactive stimuli, additional results from these studies indicate that the passive diameter of skeletal muscle arterioles is reduced in OZR versus lean Zucker rats (LZR). On the basis of these prior observations, the present study evaluated structural alterations to the skeletal muscle microcirculation as potential contributors to an elevated vascular resistance. Isolated skeletal muscle resistance arterioles exhibited a reduced passive diameter at all levels of intralumenal pressure and a left-shifted stress-strain curve in OZR versus LZR, indicative of structural remodeling of individual arterioles. Histological analyses using Griffonia simplicifolia I lectin-stained sections of skeletal muscle demonstrated reduced microvessel density (rarefaction) in OZR versus LZR, suggesting remodeling of entire microvascular networks. Finally, under maximally dilated conditions, constant flow-perfused skeletal muscle of OZR exhibited significant elevations in perfusion pressure versus LZR, indicative of an increased resistance to perfusion within the microcirculation. These data suggest that developing structural alterations to the skeletal muscle microcirculation in OZR result in elevated vascular resistance, which may, acting in concert with impaired arteriolar reactivity, contribute to blunted active hyperemic responses and compromised performance of in situ skeletal muscle with elevated metabolic demand.
C1 Med Coll Wisconsin, Dept Physiol, Milwaukee, WI 53226 USA.
C3 Medical College of Wisconsin
RP Frisbee, JC (corresponding author), Med Coll Wisconsin, Dept Physiol, 8701 Watertown Plank Rd, Milwaukee, WI 53226 USA.
OI Frisbee, Jefferson/0000-0003-2751-0599
FU NHLBI NIH HHS [HL-29587, HL-65289] Funding Source: Medline
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NR 31
TC 77
Z9 87
U1 0
U2 1
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0363-6135
J9 AM J PHYSIOL-HEART C
JI Am. J. Physiol.-Heart Circul. Physiol.
PD JUL
PY 2003
VL 285
IS 1
BP H104
EP H111
DI 10.1152/ajpheart.00118.2003
PG 8
WC Cardiac & Cardiovascular Systems; Physiology; Peripheral Vascular
   Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Physiology
GA 687AX
UT WOS:000183354600013
PM 12649071
DA 2025-06-11
ER

PT J
AU Herr, RM
   Almer, C
   Bosle, C
   Fischer, JE
AF Herr, Raphael M.
   Almer, Christian
   Bosle, Catherin
   Fischer, Joachim E.
TI Associations of Changes in Organizational Justice with Job Attitudes and
   Health-Findings from a Prospective Study Using a Matching-Based
   Difference-in-Difference Approach
SO INTERNATIONAL JOURNAL OF BEHAVIORAL MEDICINE
LA English
DT Article
DE Organizational justice; Health; Matching; Personality;
   Difference-in-difference; White and blue collar
ID CORONARY-HEART-DISEASE; MENTAL-HEALTH; INDIVIDUAL-DIFFERENCES;
   UNDERPAYMENT INEQUITY; METABOLIC SYNDROME; SOCIAL-EXCHANGE; WORK;
   PERSONALITY; INJUSTICE; SENSITIVITY
AB Background Ample evidence indicates that unfairness at the workplace (organizational injustice) is associated with both job attitudes and health of employees. Several factors that influence these associations have been identified: e.g., personality traits, such as the Big Five traits, justice sensitivity, type of occupation (e.g., white-collar), and unobserved time-invariant factors. Previous studies only addressed parts of these issues, and the ideal research design to mitigate biases-an experiment with random assignment to a treatment and control group-is not feasible. This study therefore mimics a randomized experiment using two statistical techniques. Methods First, matching was implemented to balance the treatment and control group in confounding factors (demographics and personality) in two prospective waves (2012-2014) of observational data (4522 white-collar, 2984 blue-collar) taken from the Linked Personnel Panel, which is an employee survey representative for German private sector companies with more than 50 employees. Second, a difference-in-difference approach excludes unobserved time-invariant factors by estimating associations of changes in organizational justice (distributive, procedural, interactional) with job attitudes (job satisfaction, turnover intention) and health (general and mental) in these groups, separate for white- and blue-collar employees. Results A decrease in perceived justice was associated with lower job attitudes (less job satisfaction and higher turnover intentions), while an increase was associated with higher values. This pattern was found for white- and blue-collar workers and also for health indicators, with the latter, however, being less pronounced. Conclusions Increased fairness at the workplace is related to better job attitudes and health for white- and blue-collar employees, independent of personality traits and unobserved time-invariant factors.
C1 [Herr, Raphael M.; Almer, Christian; Bosle, Catherin; Fischer, Joachim E.] Heidelberg Univ, Mannheim Inst Publ Hlth Social & Prevent Med, Med Fac Mannheim, Mannheim, Germany.
C3 Ruprecht Karls University Heidelberg
RP Herr, RM (corresponding author), Heidelberg Univ, Mannheim Inst Publ Hlth Social & Prevent Med, Med Fac Mannheim, Mannheim, Germany.
EM raphael.herr@medma.uni-heidelberg.de
RI Herr, Raphael/GYU-5115-2022
FU Federal Ministry of Labor and Social Affairs
FX This work was supported by a grant from the Federal Ministry of Labor
   and Social Affairs. The funders had no role in the analyses, decision to
   publish, or preparation of the manuscript.
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NR 67
TC 10
Z9 10
U1 0
U2 10
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1070-5503
EI 1532-7558
J9 INT J BEHAV MED
JI Int. J. Behav. Med.
PD FEB
PY 2020
VL 27
IS 1
BP 119
EP 135
DI 10.1007/s12529-019-09841-z
EA DEC 2019
PG 17
WC Psychology, Clinical
WE Social Science Citation Index (SSCI)
SC Psychology
GA KS7KS
UT WOS:000504488400001
PM 31879857
DA 2025-06-11
ER

PT J
AU Weber, M
   Wyne, K
AF Weber, M
   Wyne, K
TI A cognitive/behavioral group intervention for weight loss in patients
   treated with atypical antipsychotics
SO SCHIZOPHRENIA RESEARCH
LA English
DT Article
DE cognitive/behavioral intervention; weight loss; atypical antipsychotics;
   schizophrenia
ID GAIN; SCHIZOPHRENIA; OLANZAPINE; BEHAVIOR; THERAPY; PROGRAM; OBESITY;
   ADULTS; DRUGS
AB Obesity and diabetes have caused problems for individuals with schizophrenia long before atypical antipsychotic agents. The prevalence of obesity, insulin resistance, impaired glucose tolerance, type 2 diabetes mellitus, dyslipidemia, and the Metabolic Syndrome has increased in people with schizophrenia as compared to the general population. Risk reduction studies for persons with obesity, diabetes, and cardiovascular disease indicate that cognitive/behavioral interventions that promote motivation and provide strategies to overcome the barriers in adherence to diet and activity modification are effective interventions for weight management and risk reduction. In the landmark multi-center randomized-controlled trial study, the Diabetes Prevention Project (DPP), a cognitive/behavioral intervention, was more successful in producing weight loss and preventing diabetes than the drugs metformin, troglitazone or placebo. This pilot study examined the effectiveness of a cognitive/behavioral group intervention, modified after the DPP program, in individuals with schizophrenia or schizoaffective disorder taking atypical antipsychotics in a large urban public mental health system. Outcome measures included body weight, body mass index, waist-hip ratios, and fasting glucose levels. Both groups demonstrated elevated fasting glucose levels and were obese with a mean BMI of 33. The group that received the cognitive/behavioral group intervention lost more weight than the treatment as usual group. The CB group participants lost an average of 5.41b or 2.9% of body weight, and those in the control group lost 1.3 lb or 0.6% body weight. The range of weight loss for the treatment group was from I to 20 lb. This pilot study has demonstrated that weight loss is possible with cognitive/behavioral interventions in a population with a psychotic disorder. (c) 2006 Elsevier B.V. All rights reserved.
C1 Univ Texas, Sch Nursing, Arlington, TX 76019 USA.
   Univ Texas, SW Med Ctr, Dept Internal Med, Div Endocrinol & Metab, Dallas, TX USA.
C3 University of Texas System; University of Texas Arlington; University of
   Texas System; University of Texas Southwestern Medical Center Dallas;
   University of Texas Dallas
RP Weber, M (corresponding author), Univ Texas, Sch Nursing, 411 S Nedderman Dr,Box 19407, Arlington, TX 76019 USA.
EM mweber@uta.edu
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NR 27
TC 100
Z9 110
U1 0
U2 18
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0920-9964
J9 SCHIZOPHR RES
JI Schizophr. Res.
PD MAR
PY 2006
VL 83
IS 1
BP 95
EP 101
DI 10.1016/j.schres.2006.01.008
PG 7
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 032QI
UT WOS:000236789000010
PM 16507343
DA 2025-06-11
ER

PT J
AU Goudarzi, MA
   Sohrabi, Z
   Hashempur, MH
   Nosratabadi, S
   Namkhah, Z
   Clark, CCT
   Haghighat, N
AF Goudarzi, Mohammad Ali
   Sohrabi, Zahra
   Hashempur, Mohammad Hashem
   Nosratabadi, Saeed
   Namkhah, Zahra
   Clark, Cain C. T.
   Haghighat, Neda
TI Does the Grape Products Intake has an Effect on Body Weight in Adults: A
   Systematic Review and Meta-analysis of Randomized Controlled Trials
SO CURRENT DRUG TARGETS
LA English
DT Review
DE Grape; anthropometry; grape seed; raisins; functional food, phytotherapy
ID ANTIOXIDANT STATUS; SEED EXTRACT; ENDOTHELIAL FUNCTION; OXIDATIVE
   STRESS; BLOOD-PRESSURE; DOUBLE-BLIND; FOOD-INTAKE; RED-WINE;
   SUPPLEMENTATION; JUICE
AB Introduction: There is a growing interest in the considerable benefits of grape products intake, as some studies have indicated that they may improve cardiometabolic risk factors. However, the widespread impact of grape products on the anthropometric indices is not fully resolved.Methods: The purpose of this systematic review and meta-analysis was to examine the effects of grape products intake on anthropometric indices in adults. Randomized controlled trials (RCT) examining the effects of grape products intake on anthropometric indices, published up to December 2021, were identified through PubMed, SCOPUS, and ISI Web of Science databases. 30 studies with 35 effect sizes, including 1284 participants (708 cases and 576 controls), were included and analyzed using a random-effects model to calculate weighted mean differences (WMDs) with 95% confidence interval (CI).Results: The outcomes have revealed grape products intake to significantly decrease body weight (p = 0.001) and body mass index (p = 0.004) in obese participants, and also, a greater effect was observed when grape seed extract was used.Conclusion: Our study suggests that grape products intake may help to decrease body weight in obese participants. Future large RCTs with longer duration and obese populations are needed to expand our findings.
C1 [Goudarzi, Mohammad Ali] Islamic Azad Univ, Dept Nutr, Shahrekord, Iran.
   [Sohrabi, Zahra] Shiraz Univ Med Sci, Student Res Comm, Sch Nutr & Food Sci, Dept Community Nutr, Shiraz 0098, Iran.
   [Hashempur, Mohammad Hashem] Shiraz Univ Med Sci, Res Ctr Tradit Med & Hist Med, Sch Med, Dept Persian Med, Shiraz, Iran.
   [Nosratabadi, Saeed] Islamic Azad Univ, Elect Hlth & Stat Surveillance Res Ctr, Dept Nutr, Sci & Res Branch, Tehran, Iran.
   [Namkhah, Zahra] Mashhad Univ Med Sci, Fac Med, Dept Nutr, Mashhad, Iran.
   [Clark, Cain C. T.] Coventry Univ, Ctr Intelligent Healthcare, Coventry CV1 5FB, England.
   [Haghighat, Neda] Shiraz Univ Med Sci, Laparoscopy Res Ctr, Shiraz, Iran.
C3 Islamic Azad University; Shiraz University of Medical Science; Shiraz
   University of Medical Science; Islamic Azad University; Mashhad
   University of Medical Sciences; Coventry University; Shiraz University
   of Medical Science
RP Haghighat, N (corresponding author), Shiraz Univ Med Sci, Laparoscopy Res Ctr, Shiraz, Iran.
EM neda.hag@gmail.com
RI nosratabadi, saeed/JAC-5290-2023; Sohrabi, Zahra/R-4948-2017; Clark,
   Cain/I-4480-2019; Haghighat, Neda/AAB-1595-2021; Hashempur,
   Mohammad/M-8736-2017
OI Hashempur, Mohammad Hashem/0000-0002-6700-9304; Clark, Dr.
   Cain/0000-0002-6610-4617; namkhah, zahra/0000-0002-6485-9071; haghighat,
   neda/0000-0003-2749-4306
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NR 60
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PU BENTHAM SCIENCE PUBL LTD
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PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1389-4501
EI 1873-5592
J9 CURR DRUG TARGETS
JI Curr. Drug Targets
PY 2024
VL 25
IS 2
BP 121
EP 134
DI 10.2174/0113894501272740231219072525
PG 14
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA LM1Y6
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DA 2025-06-11
ER

PT J
AU Ruskovska, T
   Budic-Leto, I
   Corral-Jara, KF
   Ajdzanovic, V
   Arola-Arnal, A
   Bravo, FI
   Deligiannidou, GE
   Havlik, J
   Janeva, M
   Kistanova, E
   Kontogiorgis, C
   Krga, I
   Massaro, M
   Miler, M
   Milosevic, V
   Morand, C
   Scoditti, E
   Suárez, M
   Vauzour, D
   Milenkovic, D
AF Ruskovska, Tatjana
   Budic-Leto, Irena
   Corral-Jara, Karla Fabiola
   Ajdzanovic, Vladimir
   Arola-Arnal, Anna
   Bravo, Francisca Isabel
   Deligiannidou, Georgia-Eirini
   Havlik, Jaroslav
   Janeva, Milkica
   Kistanova, Elena
   Kontogiorgis, Christos
   Krga, Irena
   Massaro, Marika
   Miler, Marko
   Milosevic, Verica
   Morand, Christine
   Scoditti, Egeria
   Suarez, Manuel
   Vauzour, David
   Milenkovic, Dragan
TI Systematic Bioinformatic Analyses of Nutrigenomic Modifications by
   Polyphenols Associated with Cardiometabolic Health in Humans-Evidence
   from Targeted Nutrigenomic Studies
SO NUTRIENTS
LA English
DT Article
DE systematic literature search; nutrigenomics; integrative bioinformatics;
   polyphenols; cardiometabolic health; human
ID BLOOD MONONUCLEAR-CELLS; OLIVE OIL POLYPHENOLS; INSULIN-RESISTANCE;
   OXIDATIVE STRESS; ENDOTHELIAL-CELLS; ADIPOSE-TISSUE; DIETARY-INTAKE;
   IN-VIVO; EXPRESSION; GENES
AB Cardiometabolic disorders are among the leading causes of mortality in the human population. Dietary polyphenols exert beneficial effects on cardiometabolic health in humans. Molecular mechanisms, however, are not completely understood. Aiming to conduct in-depth integrative bioinformatic analyses to elucidate molecular mechanisms underlying the protective effects of polyphenols on cardiometabolic health, we first conducted a systematic literature search to identify human intervention studies with polyphenols that demonstrate improvement of cardiometabolic risk factors in parallel with significant nutrigenomic effects. Applying the predefined inclusion criteria, we identified 58 differentially expressed genes at mRNA level and 5 miRNAs, analyzed in peripheral blood cells with RT-PCR methods. Subsequent integrative bioinformatic analyses demonstrated that polyphenols modulate genes that are mainly involved in the processes such as inflammation, lipid metabolism, and endothelial function. We also identified 37 transcription factors that are involved in the regulation of polyphenol modulated genes, including RELA/NFKB1, STAT1, JUN, or SIRT1. Integrative bioinformatic analysis of mRNA and miRNA-target pathways demonstrated several common enriched pathways that include MAPK signaling pathway, TNF signaling pathway, PI3K-Akt signaling pathway, focal adhesion, or PPAR signaling pathway. These bioinformatic analyses represent a valuable source of information for the identification of molecular mechanisms underlying the beneficial health effects of polyphenols and potential target genes for future nutrigenetic studies.
C1 [Ruskovska, Tatjana; Janeva, Milkica] Goce Delcev Univ, Fac Med Sci, Stip 2000, North Macedonia.
   [Budic-Leto, Irena] Inst Adriat Crops & Karst Reclamat, Split 21000, Croatia.
   [Corral-Jara, Karla Fabiola; Krga, Irena; Morand, Christine; Milenkovic, Dragan] Univ Clermont Auvergne, Inst Natl Rech Agr Alimentat & Environm INRAE, Unite Nutr Humaine UNH, Fac Med, F-63000 Clermont Ferrand, France.
   [Ajdzanovic, Vladimir; Miler, Marko; Milosevic, Verica] Univ Belgrade, Natl Inst Republ Serbia, Inst Biol Res Sinisa Stankovic, Belgrade 11060, Serbia.
   [Arola-Arnal, Anna; Bravo, Francisca Isabel; Suarez, Manuel] Univ Rovira & Virgili, Dept Bioquim & Biotecnol, Nutrigen Res Grp, E-43007 Tarragona, Spain.
   [Deligiannidou, Georgia-Eirini; Kontogiorgis, Christos] Democritus Univ Thrace, Dept Med, Dragana 68100, Alexandroupolis, Greece.
   [Havlik, Jaroslav] Czech Univ Life Sci, Dept Food Sci, Prague 16521, Czech Republic.
   [Kistanova, Elena] Bulgarian Acad Sci, Inst Biol & Immunol Reprod, Sofia 1113, Bulgaria.
   [Krga, Irena] Univ Belgrade, Ctr Res Excellence Nutr & Metab, Inst Med Res, Natl Inst Republ Serbia, Belgrade 11060, Serbia.
   [Massaro, Marika; Scoditti, Egeria] Natl Res Council CNR, Inst Clin Physiol IFC, I-73100 Lecce, Italy.
   [Vauzour, David] Univ East Anglia, Norwich Med Sch, Norwich NR4 7TJ, Norfolk, England.
   [Milenkovic, Dragan] Univ Calif Davis, Sch Med, Dept Internal Med, Div Cardiovasc Med, Davis, CA 95616 USA.
C3 Goce Delcev University of Stip; Institute for Adriatic Crops and Karst
   Reclamation Split; Universite Clermont Auvergne (UCA); INRAE; University
   of Belgrade; Universitat Rovira i Virgili; Democritus University of
   Thrace; Czech University of Life Sciences Prague; Bulgarian Academy of
   Sciences; University of Belgrade; Consiglio Nazionale delle Ricerche
   (CNR); Istituto di Fisiologia Clinica (IFC-CNR); University of East
   Anglia; University of California System; University of California Davis
RP Milenkovic, D (corresponding author), Univ Clermont Auvergne, Inst Natl Rech Agr Alimentat & Environm INRAE, Unite Nutr Humaine UNH, Fac Med, F-63000 Clermont Ferrand, France.; Milenkovic, D (corresponding author), Univ Calif Davis, Sch Med, Dept Internal Med, Div Cardiovasc Med, Davis, CA 95616 USA.
EM tatjana.ruskovska@ugd.edu.mk; irena.budic-leto@krs.hr;
   karla-fabiola.corral-jara@inrae.fr; avlada@ibiss.bg.ac.rs;
   anna.arola@urv.cat; franciscaisabel.bravo@urv.cat; edeligia@med.duth.gr;
   jaroslay.havlik@gmail.com; milkica.janeva@ugd.edu.mk;
   kistanova@gmail.com; ckontogi@med.duth.gr; irenakrga@yahoo.com;
   marika@ifc.cnr.it; marko.miler@ibiss.bg.ac.rs;
   verica.milosevic@gmail.com; christine.morand@inra.fr;
   egeria.scoditti@ifc.cnr.it; manuel.suarez@urv.cat; d.vauzour@uea.ac.uk;
   dragan.milenkovic@inrae.fr
RI Bravo, Francisca/L-4409-2019; Deligiannidou,
   Georgia-Eirini/AAL-6908-2021; Miler, Marko/AAC-8346-2019; Massaro,
   Marika/HNI-1375-2023; Krga, Irena/AAC-4879-2020; Ruskovska,
   Tatjana/V-4885-2019; VAUZOUR, David/C-2245-2008; Suarez Recio,
   Manuel/F-5039-2016; Arola-Arnal, Anna/C-2087-2015; Kistanova,
   Elena/J-3532-2016; SCODITTI, EGERIA/J-8609-2016; Arsova,
   Milkica/JIH-1445-2023; Havlik, Jaroslav/F-3371-2011
OI VAUZOUR, David/0000-0001-5952-8756; Deligiannidou, Georgia
   -Eirini/0000-0003-3976-4473; Suarez Recio, Manuel/0000-0003-0122-8253;
   Milenkovic, Dragan/0000-0001-6353-0912; Arola-Arnal,
   Anna/0000-0001-6529-1345; Kistanova, Elena/0000-0002-5239-1715; Miler,
   Marko/0000-0002-8366-3138; SCODITTI, EGERIA/0000-0003-2753-8487; Arsova,
   Milkica/0000-0002-1694-3818; Krga, Irena/0000-0002-2073-2896; Ruskovska,
   Tatjana/0000-0002-4300-4891; Havlik, Jaroslav/0000-0003-1900-0951;
   Budic-Leto, Irena/0000-0002-7697-8967; Bravo, Francisca
   Isabel/0000-0002-6468-3088; Massaro, Marika/0000-0001-6124-5077;
   Kontogiorgis, Christos/0000-0001-7835-8246
FU COST Action FA1403-European Cooperation in Science and Technology
FX This study was funded by COST Action FA1403-European Cooperation in
   Science and Technology (www.cost.eu).
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   Zhou YY, 2019, NAT COMMUN, V10, DOI 10.1038/s41467-019-09234-6
NR 95
TC 16
Z9 16
U1 0
U2 16
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JUL
PY 2021
VL 13
IS 7
AR 2326
DI 10.3390/nu13072326
PG 28
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA TN5XW
UT WOS:000676308300001
PM 34371836
OA Green Published, Green Submitted, gold, Green Accepted
DA 2025-06-11
ER

PT J
AU Dahlui, M
   Jahan, NK
   Majid, HA
   Jalaludin, MY
   Murray, L
   Cantwell, M
   Su, TT
   Al-Sadat, N
AF Dahlui, M.
   Jahan, N. K.
   Majid, H. A.
   Jalaludin, M. Y.
   Murray, L.
   Cantwell, M.
   Su, T. T.
   Al-Sadat, N.
CA MyHeARTs Grp
TI Risk and Protective Factors for Cigarette Use in Young Adolescents in a
   School Setting: What Could Be Done Better?
SO PLOS ONE
LA English
DT Article
ID SMOKING INITIATION; METABOLIC SYNDROME; PARENTAL SMOKING; PEER
   INFLUENCE; MALAYSIA; PREVALENCE; STUDENTS; HEALTH; CESSATION; DISTRICT
AB Smoking among Malaysian adolescents remains a public health concern despite concerted efforts in tobacco control. The aims of this study were to examine the prevalence and determinants of current-smoking status in young adolescents. This cross sectional study used the first round of the Malaysian Health and Adolescents Research Team's prospective cohort study. It was conducted in three States of the Central and Northern regions of Peninsular Malaysia between March and May 2012. The study used the multistage stratified sampling design. A total of 1,342 adolescents of both sexes, aged 12-13 years, were sampled from randomly selected urban and rural national schools. Information on current smoking status and associated factors were collected by a self-administered, pre-tested, validated, structured questionnaire. Seven percent of the samples were current-smokers; the majority (62%) of them started smoking at the age of 11 years or below. The prevalence of current smoking was significantly higher in males (odds ratio [OR] = 2.37; 95% CI: 1.46, 3.84), those who were influenced by smoker friends (OR = 8.35; 95% CI: 4.90, 14.25), who were unaware of the health risks of smoking (OR = 1.85; 95% CI: 1.02, 3.36) and who reported a lack of satisfaction about their overall life (OR = 3.26; 95% CI: 1.73, 6.12). The study findings provide valuable information to strengthen the existing school-based smoking prevention program through integration of social competence and social influence curricula. The program should empower the young adolescents to refuse tobacco offers, to overcome social influences and to resist peer pressure to avoid starting smoking. Particular focuses to include mental health service to prevent both emotional and behavioural problems are needed.
C1 [Dahlui, M.; Majid, H. A.; Su, T. T.; Al-Sadat, N.] Univ Malaya, Fac Med, Ctr Populat Hlth CePH, Kuala Lumpur, Malaysia.
   [Dahlui, M.; Majid, H. A.; Su, T. T.; Al-Sadat, N.] Univ Malaya, Dept Social & Prevent Med, Fac Med, Kuala Lumpur, Malaysia.
   [Jahan, N. K.] Monash Univ Malaysia, SEACO, Segamat, Malaysia.
   [Jahan, N. K.] Monash Univ Malaysia, Sch Med & Hlth Sci, Segamat, Malaysia.
   [Jalaludin, M. Y.] Univ Malaya, Fac Med, Dept Paediat, Kuala Lumpur, Malaysia.
   [Murray, L.; Cantwell, M.] Queens Univ Belfast, Ctr Publ Hlth, Belfast, Antrim, North Ireland.
C3 Universiti Malaya; Universiti Malaya; Universiti Malaya; Queens
   University Belfast
RP Dahlui, M (corresponding author), Univ Malaya, Fac Med, Ctr Populat Hlth CePH, Kuala Lumpur, Malaysia.
EM maznahd@ummc.edu.my
RI SU, TIN/B-9968-2010; Dahlui, Maznah/F-9665-2010; Jalaludin,
   Muhammad/B-9172-2010; Dahlui, Maznah/B-8976-2010; Abdul Majid,
   Hazreen/B-8619-2010; Sutan, Rosnah/F-4732-2017
OI Su, Tin Tin/0000-0003-0387-6406; Dahlui, Maznah/0000-0003-4923-9410;
   Abdul Majid, Hazreen/0000-0002-2718-8424; Jahan, Nowrozy
   Kamar/0000-0001-6584-5010; Sutan, Rosnah/0000-0001-9956-4727
FU University of Malaya [RG299-11HTM, UMQUB3D-2011]
FX This project was sponsored by a University of Malaya Research Grant
   (RG299-11HTM) and Vice Chancellor Research Grant (UMQUB3D-2011).
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NR 45
TC 11
Z9 14
U1 0
U2 8
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JUN 11
PY 2015
VL 10
IS 6
AR e0129628
DI 10.1371/journal.pone.0129628
PG 12
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Science & Technology - Other Topics
GA CK3FB
UT WOS:000356100900064
PM 26068668
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Ganeshalingam, AA
   Uhrenholt, NG
   Arnfred, S
   Gaede, PH
   Bilenberg, N
   Frystyk, J
AF Ganeshalingam, Ashok Ainkaran
   Uhrenholt, Nicolai Gundtoft
   Arnfred, Sidse
   Gaede, Peter Haulund
   Bilenberg, Niels
   Frystyk, Jan
TI Home-based Intervention with Semaglutide Treatment of
   Neuroleptic-Related Prediabetes (HISTORI): protocol describing a
   prospective, randomised, placebo controlled and double-blinded
   multicentre trial
SO BMJ OPEN
LA English
DT Article
DE PREVENTIVE MEDICINE; General diabetes; Schizophrenia & psychotic
   disorders; Primary Prevention; Obesity
ID QUALITY-OF-LIFE; BODY-MASS INDEX; WEIGHT-GAIN; ANTIPSYCHOTIC-DRUGS;
   SCHIZOPHRENIA; RISK; IMPACT; DISORDER; OBESITY; PEOPLE
AB Introduction Subjects with schizophrenia have a 2-3 fold higher mortality rate than the general population and a reduced life expectancy of 10-20 years. Approximately one-third of this excess mortality has been attributed to obesity-related type 2 diabetes (T2D) and to cardiovascular disease. Glucagon-like peptide-1 (GLP-1) analogues increase satiety and delay gastric emptying, thereby reducing food intake and weight. GLP-1 analogues also exert beneficial effects on cardiovascular outcomes in high-risk patients with T2D. Our aim is to investigate whether 30 weeks add-on treatment with the GLP-1 analogue semaglutide can reduce HbA1c sufficiently to reverse pre-diabetes and the metabolic syndrome in overweight schizophrenic patients. Methods and analysis We will perform a 30 week, two-armed, multicentre, superiority, double-blinded, randomised trial investigating the effect of weekly injections of semaglutide versus placebo in mental health facilities in Region of Southern Denmark and Region of Zealand, Denmark. In total, 154 adults with schizophrenia spectrum disease, aged 18-60 years treated with second generation antipsychotic treatment, HbA1c 39-47 mmol/mol and body mass index >27 kg/m(2) will be randomised to injections of 1.0 mg semaglutide or placebo. The primary outcome is changes in HbA1c. Secondary outcomes encompass metabolic measures, psychotic symptoms and quality of life. Exploratory outcomes encompass insulin sensitivity, cardiovascular risk profile, medication adherence, general well-being and physical activity. Ethics and dissemination This study will be carried out in accordance with the Declaration of Helsinki and Good Clinical Practice guidelines. This research has obtained approval from both the Danish Medicines Agency and The Regional Committees on Health Research Ethics for Southern Denmark.
C1 [Ganeshalingam, Ashok Ainkaran; Frystyk, Jan] Odense Univ Hosp, Dept Endocrinol, Endocrine Res Unit, Odense, Denmark.
   [Ganeshalingam, Ashok Ainkaran; Frystyk, Jan] Odense Univ Hosp, Fac Hlth, Dept Clin Res, Odense, Denmark.
   [Ganeshalingam, Ashok Ainkaran] Univ Hosp Southern Denmark, Lillebaelt Hosp, Dept Internal Med, Kolding, Denmark.
   [Ganeshalingam, Ashok Ainkaran] Odense Univ Hosp, Dept Endocrinol, Odense, Denmark.
   [Uhrenholt, Nicolai Gundtoft] Reg Zealand, Res Unit West, Psychiat West, Slagelse, Denmark.
   [Uhrenholt, Nicolai Gundtoft; Bilenberg, Niels] Univ Southern Denmark, Dept Child & Adolescent Mental Hlth Odense, Mental Hlth Serv Reg Southern Denmark, Odense, Denmark.
   [Arnfred, Sidse] Univ Copenhagen, Copenhagen, Denmark.
   [Gaede, Peter Haulund] Slagelse Hosp, Dept Cardiol & Endocrinol, Slagelse, Denmark.
   [Bilenberg, Niels] Univ Southern Denmark, Fac Hlth Sci, Dept Clin Res, Odense, Denmark.
C3 University of Southern Denmark; Odense University Hospital; University
   of Southern Denmark; Odense University Hospital; University of Southern
   Denmark; Lillebaelt Hospital; University of Southern Denmark; Odense
   University Hospital; University of Southern Denmark; University of
   Copenhagen; University of Southern Denmark
RP Ganeshalingam, AA (corresponding author), Odense Univ Hosp, Dept Endocrinol, Endocrine Res Unit, Odense, Denmark.; Ganeshalingam, AA (corresponding author), Odense Univ Hosp, Fac Hlth, Dept Clin Res, Odense, Denmark.; Ganeshalingam, AA (corresponding author), Univ Hosp Southern Denmark, Lillebaelt Hosp, Dept Internal Med, Kolding, Denmark.; Ganeshalingam, AA (corresponding author), Odense Univ Hosp, Dept Endocrinol, Odense, Denmark.
EM ashok.ganeshalingam@rsyd.dk
RI Frystyk, Jan/HKP-1836-2023; Arnfred, Sidse/AAV-8519-2021; Bilenberg,
   Niels/I-6027-2014
OI Ganeshalingam, Ashok Ainkaran/0000-0003-2218-5045; Bilenberg,
   Niels/0000-0002-5838-556X; Uhrenholt, Nicolai/0000-0002-6973-4585;
   Gaede, Peter/0000-0002-1457-2742
FU Novo Nordisk Foundation [DKK8 584 959]; Steno Diabetes Center Zealand,
   Denmark [DKK660 000]; Steno Diabetes Center Odense, Denmark [DKK578
   000]; Annum (Region Zealand) [DDK20 000]; Slagelse Puljen 2020: The
   Region of Zealand, Denmark [DKK240 000]; Slagelse Puljen 2022 [DKK150
   000 DKK]; Region Sjaellands Sundhedsvidenskabelige Forskningsfond 2022
   [DKK252 631]
FX Novo Nordisk Foundation: DKK8 584 959 (salary and tuition fee PHD
   Students and study- nurses, running expenses, biochemical and laboratory
   procedures, TAP personal, mileage allowance). Research Grant from Steno
   Diabetes Center Zealand, Denmark: DKK660 000. Research Grant from Steno
   Diabetes Center Odense, Denmark: DKK578 000. Annum (Region Zealand) to
   PhD- student Nicolai Uhrenholt: DDK20 000 per year for 3 years (DKK60
   000 in total). Slagelse Puljen 2020: The Region of Zealand, Denmark:
   DKK240 000. Slagelse Puljen 2022: DKK150 000 DKK. Region Sjaellands
   Sundhedsvidenskabelige Forskningsfond 2022: DKK252 631. Furthermore,
   Novo Nordisk A/S will provide investigational drug and placebo free of
   charge for sponsor, but is otherwise not involved in the study. The
   scientists involved will conduct the experiment out of general
   scientific interest without personal financial gain. None of the
   investigators involved have financial interests (including shares,
   direct employment, members of advisory boards) in the drug company that
   produces the active drug used in the study. None of the participants in
   the study will receive any provision for participation. Participants
   will receive mileage allowances. Any harm as a result of study
   participation will be covered by the Danish Patient Compensation.
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NR 52
TC 2
Z9 2
U1 2
U2 5
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2044-6055
J9 BMJ OPEN
JI BMJ Open
PD MAR
PY 2024
VL 14
IS 3
AR e077173
DI 10.1136/bmjopen-2023-077173
PG 9
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA UU5N1
UT WOS:001250588600074
PM 38503415
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Younossi, I
   Stepanova, M
   Walters, M
   Golabi, P
   Srishord, M
   Younossi, ZM
AF Younossi, Issah
   Stepanova, Maria
   Walters, Mercedes
   Golabi, Pegah
   Srishord, Manirath
   Younossi, Zobair M.
TI Health-Related Quality of Life and Health Care Resource Utilization in
   Patients With Chronic Liver Disease and Primary Liver Cancer in the
   United States: Analysis of Medical Expenditure Panel Survey
SO JOURNAL OF CLINICAL AND EXPERIMENTAL HEPATOLOGY
LA English
DT Article
DE national survey; disease burden; patient-reported outcomes; metabolic
   syndrome; outcomes
ID HEPATOCELLULAR-CARCINOMA
AB Background: Worldwide, liver cancer (LC) is the fifth and third most common type of cancer and cancer-related mortality, respectively. Our aim was to assess health-related quality of life (HRQL) and resource utilization in chronic liver disease (CLD) patients with LC. Methods: We used the Medical Expenditure Panel Survey 2004-2013. All patients had HRQL (Short Form-12, Patient Health Questionnaire-2, Kessler Psychological Distress Scale) and resource utilization data. We used patients with CLD without LC and colon cancer (CC) as controls. Results: A total of 1882 CLD patients (53 +/- 14 years, 45% male, 53% white, 15% black, 23% Hispanic, 6% Asian, 42% employed, 48% private insurance, and 11% uninsured) were included. Of the cohort, 102 (5.4%) patients had LC. LC patients were older, more likely to be male and white, less employed but less likely uninsured than CLD patients without LC (all P < 0.05). In comparison to both non-LC CLD and CC controls, LC had worse health: 40% vs. 27% vs. 25% reported fair health and 29% vs. 20% vs. 16% poor health status (P < 0.05). Furthermore, LC patients more frequently reported physical limitations: 51% vs. 35% vs. 35%, respectively (P = 0.01). Physical HRQL scores were lower in LC patients compared with both CLD and CC controls. Although mental health scores in LC were similar to non-LC CLD controls, they were lower than in CC. In addition, most aspects of healthcare resource utilization were higher for LC patients compared with both non-LC CLD and CC controls. Conclusion: While having CLD causes impairment of patients' HRQL, LC further adds to this impairment and also contributes to a substantial resource utilization.
C1 [Younossi, Issah; Stepanova, Maria; Golabi, Pegah; Srishord, Manirath; Younossi, Zobair M.] Inova Hlth Syst, Betty & Guy Beatty Ctr Integrated Res, Falls Church, VA USA.
   [Younossi, Issah; Stepanova, Maria; Walters, Mercedes] Ctr Outcomes Res Liver Dis, Washington, DC USA.
   [Golabi, Pegah; Srishord, Manirath; Younossi, Zobair M.] Inova Fairfax Med Campus, Dept Med, Ctr Liver Dis, Falls Church, VA USA.
   [Golabi, Pegah; Younossi, Zobair M.] Inova Hlth Syst, Inova Med, Falls Church, VA USA.
C3 Inova Health System; Inova Fairfax Hospital; Inova Health System
RP Younossi, ZM (corresponding author), Betty & Guy Beatty Ctr Integrated Res, Claude Moore Hlth Educ & Res Bldg,3300 Gallows Rd, Falls Church, VA 22042 USA.
EM zobair.younossi@inova.org
RI Stepanova, Maria/V-5513-2019; Younossi, Zobair M./JRY-9916-2023
OI Golabi, Pegah/0000-0001-9818-0983
CR Balogh J, 2016, J HEPATOCELL CARCINO, V3, P41, DOI 10.2147/JHC.S61146
   Cancer, 2018, World Health Organization
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   Massarweh NN, 2017, CANCER CONTROL, V24, DOI 10.1177/1073274817729245
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NR 8
TC 3
Z9 3
U1 0
U2 3
PU ELSEVIER - DIVISION REED ELSEVIER INDIA PVT LTD
PI NEW DELHI
PA 17-A/1 MAIN RING ROAD, LAJPAT NAGAR IV, NEW DELHI, 110024, INDIA
SN 0973-6883
EI 2213-3453
J9 J CLIN EXP HEPATOL
JI J. Clin. Exp. Hepatol.
PD MAR-APR
PY 2022
VL 12
IS 2
BP 272
EP 277
DI 10.1016/j.jceh.2021.12.012
EA MAR 2022
PG 6
WC Gastroenterology & Hepatology
WE Emerging Sources Citation Index (ESCI)
SC Gastroenterology & Hepatology
GA ZW4RK
UT WOS:000771202000003
PM 35535094
OA Green Published
DA 2025-06-11
ER

PT J
AU Kong, MW
   Pei, ZY
   Xie, YY
   Gao, Y
   Li, J
   He, GX
AF Kong, Mowei
   Pei, Zhenying
   Xie, Yuyu
   Gao, Yu
   Li, Jun
   He, Guoxiang
TI Prognostic factors of MINOCA and their possible mechanisms
SO PREVENTIVE MEDICINE REPORTS
LA English
DT Article
DE Myocardial infarction with non -obstructive; coronary arteries;
   Cardiovascular outcomes; Metabolic disorders; Risk factors; Biological
   landmark
ID CORONARY-ARTERY-DISEASE; ELEVATION MYOCARDIAL-INFARCTION;
   SEX-DIFFERENCES; CYSTATIN-C; OUTCOMES; ACTIVATION; MORTALITY; THERAPY;
   STRESS; TRENDS
AB Objective: Despite not showing substantial stenosis of coronary arteries, Myocardial Infarction with NonObstructive Coronary Arteries (MINOCA) presents with myocardial ischemia injury, thus having a grave prognosis and a high risk of long-term complications. This necessitates increased clinical attention and exploration of its root causes to prevent a similar crisis. Methods: Research on MINOCA is limited, especially in terms of its clinical attributes, long-term outlook, risk stratification, and prognosis -linked cardiometabolic risk factors. This review aims to fill these gaps, providing an extensive overview of clinical trials and studies on MINOCA to separate the issue from the presence of nonobstructive coronary arteries in cardiac patients. Results: It has been found that MINOCA patients still face a high risk of long-term adverse events. Due to social and physiological factors, the hospital mortality rate is higher among women, and they are also more susceptible to MINOCA. Cardiac metabolic risk factors, including disorder of glucose and lipid metabolism, as well as changes in serum CysC levels, have significant impacts on the occurrence and prognosis of MINOCA. Conclusions: Further research is still needed to fully understand the complex biological mechanisms underlying the prognostic factors of MINOCA. A profound understanding of these factors could reveal potential targets for improving prognosis, thereby indicating new strategies for managing this cardiovascular condition.
C1 [Kong, Mowei; Pei, Zhenying; Li, Jun; He, Guoxiang] Guiqian Int Gen Hosp, Dept Cardiol, Guiyang 550018, Guizhou, Peoples R China.
   [Xie, Yuyu] Chengdu Fifth Peoples Hosp, Dept Dermatol, Chengdu 610000, Sichuan, Peoples R China.
   [Gao, Yu] Chengde Med Univ, Dept Endocrinol, Affiliated Hosp, Chengde 067000, Hebei, Peoples R China.
C3 Chengde Medical University
RP Pei, ZY; He, GX (corresponding author), Guiqian Int Gen Hosp, Dept Cardiol, Guiyang 550018, Guizhou, Peoples R China.
EM 786889175@qq.com; heguoxiangsw@aliyun.com
RI Kong, Mowei/AEW-6157-2022
OI Kong, Mowei/0000-0002-1214-164X
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NR 90
TC 2
Z9 2
U1 0
U2 1
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
EI 2211-3355
J9 PREV MED REP
JI Prev. Med. Rep.
PD MAR
PY 2024
VL 39
AR 102643
DI 10.1016/j.pmedr.2024.102643
EA FEB 2024
PG 9
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA OM0Y5
UT WOS:001207584500001
PM 38426041
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Tavakoli-Rouzbehani, OM
   Abbasnezhad, M
   Kheirouri, S
   Alizadeh, M
AF Tavakoli-Rouzbehani, Omid Mohammad
   Abbasnezhad, Mohsen
   Kheirouri, Sorayya
   Alizadeh, Mohammad
TI Efficacy of nigella sativa oil on endothelial function and atherogenic
   indices in patients with coronary artery diseases: A randomized,
   double-blind, placebo-control clinical trial
SO PHYTOTHERAPY RESEARCH
LA English
DT Article
DE Atherogenic indices; Cardiometabolic risk factors; coronary artery
   disease; Endothelial dysfunction; nigella sativa
ID OXIDATIVE STRESS; ADHESION MOLECULES; CELL-ADHESION;
   RHEUMATOID-ARTHRITIS; DYSFUNCTION; THYMOQUINONE; INFLAMMATION;
   ATTENUATION; MECHANISMS; RECEPTOR
AB A therapeutic compound with antioxidant and anti-inflammatory effects might be a practical approach in endothelial dysfunction caused by oxidation and inflammation associated with atherosclerosis. Therefore, we aim to examine the efficacy of Nigella sativa (NS) oil supplementation on endothelial function and atherogenic indices in coronary artery disease (CAD) patients. Sixty individuals aged between 35 to 65 years old were recruited and divided into two groups, receiving either 2 g/daily of NS oil or sunflower oil as the placebo for 8 weeks. Serum levels of adhesion molecules, oxidative markers, and atherogenic parameters were evaluated at the starting point and the end of supplementation. Serum levels of vascular cell adhesion protein 1 (sVCAM-1) [-264.44 95% C, (156.83, 372.04)], intercellular adhesion molecule 1 (sICAM-1) [-132.38 95% C, (40.64, 224.1)], and malondialdehyde (MDA) [-0.21 95% C, (0.03, 0.40)] declined significantly following NS supplementation, while total antioxidant capacity increased [0.03 95% C, (0.03, 0.16)]. NS oil supplementation demonstrated a potential beneficial effect on endothelial function by reducing ICAM-1, VCAM-1 levels and affecting oxidative markers. However, further studies are necessary to elucidate NS oil as a therapeutic agent and complementary therapy in patients with stable CAD.
C1 [Tavakoli-Rouzbehani, Omid Mohammad] Tabriz Univ Med Sci, Student Res Comm, Tabriz, Iran.
   [Tavakoli-Rouzbehani, Omid Mohammad; Alizadeh, Mohammad] Tabriz Univ Med Sci, Nutr Res Ctr, Fac Nutr & Food Sci, Tabriz, Iran.
   [Abbasnezhad, Mohsen] Tabriz Univ Med Sci, Cardiovasc Res Ctr, Tabriz, Iran.
   [Kheirouri, Sorayya] Tabriz Univ Med Sci, Fac Nutr & Food Sci, Dept Clin Nutr, Tabriz, Iran.
C3 Tabriz University of Medical Science; Tabriz University of Medical
   Science; Tabriz University of Medical Science; Tabriz University of
   Medical Science
RP Tavakoli-Rouzbehani, OM; Alizadeh, M (corresponding author), Tabriz Univ Med Sci, Fac Nutr & Food Sci, Dept Clin Nutr, Tabriz, Iran.
EM omidmtr@gmail.com; mdalizadeh@tbzmed.ac.ir
RI Alizadeh, Mohammad/M-4703-2017
FU Vice-chancellor for Research and Student Research Committee of Tabriz
   University of Medical Sciences, Tabriz, Iran [63092]
FX Vice-chancellor for Research and Student Research Committee of Tabriz
   University of Medical Sciences, Tabriz, Iran, Grant/Award Number: 63092
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NR 44
TC 7
Z9 7
U1 1
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0951-418X
EI 1099-1573
J9 PHYTOTHER RES
JI Phytother. Res.
PD DEC
PY 2022
VL 36
IS 12
BP 4516
EP 4526
DI 10.1002/ptr.7568
EA JUL 2022
PG 11
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 6W1BK
UT WOS:000829266200001
PM 35871718
DA 2025-06-11
ER

PT J
AU Sebeková, K
   Sebeková, KB
AF Sebekova, Katarina
   Sebekova, Katarina Brouder
TI Glycated proteins in nutrition: Friend or foe?
SO EXPERIMENTAL GERONTOLOGY
LA English
DT Review
DE Dietary advanced glycation end products; Skin autofluorescence;
   Beneficial health effects; Negative health effects; Cardiometabolic risk
ID N-EPSILON-CARBOXYMETHYLLYSINE; MAILLARD REACTION-PRODUCTS; GESTATIONAL
   DIABETES-MELLITUS; CACO-2 CELL MONOLAYERS; END-PRODUCTS; SKIN
   AUTOFLUORESCENCE; OXIDATIVE STRESS; LIQUID-CHROMATOGRAPHY;
   INSULIN-RESISTANCE; DAIRY-PRODUCTS
AB Advanced glycation end products (AGEs) are formed in in vivo, and accumulate in tissues and body fluids during ageing. Endogenous AGE-modified proteins show altered structure and function, and may interact with receptor for AGEs (RAGE) resulting in production of reactive oxygen species, inflammatory, atherogenic and diabetogenic responses. AGEs are also formed in thermally processed foods. Studies in rodents document that dietary AGEs are partially absorbed into circulation, and accumulate in different tissues. Knowledge on the health effects of high dietary intake of AGEs is incomplete and contradictory. In this overview we discuss the data from experimental and clinical studies, either those supporting the assumption that restriction of dietary AGEs associated with health benefits, or data suggesting that dietary intake of AGEs associates with positive health outcomes. We polemicize whether the effects of exaggerated intake or restriction of highly thermally processed foods might be straightforward interpreted as the effects of AGEs-rich vs. AGEs-restricted diets. We also underline the lack of studies, and thus a poor knowledge, on the effects of different single chemically defined AGEs administration, concurrent intake of different dietary AGEs, of load with dietary AGEs corresponding to the habitual diet in humans, and on those of dietary AGEs in vulnerable populations, such as infants and particularly elderly.
C1 [Sebekova, Katarina] Comenius Univ, Inst Mol Biomed, Med Fac, Sasinkova 4, Bratislava 81105, Slovakia.
   [Sebekova, Katarina Brouder] John Radcliffe Hosp, Intens Care Unit, Oxford, England.
C3 Comenius University Bratislava; University of Oxford
RP Sebeková, K (corresponding author), Comenius Univ, Inst Mol Biomed, Med Fac, Sasinkova 4, Bratislava 81105, Slovakia.
EM kata.sebekova@gmail.com
RI Sebekova, Katarina/GSD-7056-2022; Sebekova, Katarina/H-4906-2016
OI Sebekova, Katarina/0000-0002-9641-9265
FU Ministry of Education, Science, Research and Sport of the Slovak
   Republic [VEGA 1/0062/2016]
FX This review was elaborated in frames of the project supported by the
   grant from Ministry of Education, Science, Research and Sport of the
   Slovak Republic (VEGA 1/0062/2016).
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NR 198
TC 19
Z9 20
U1 0
U2 59
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0531-5565
EI 1873-6815
J9 EXP GERONTOL
JI Exp. Gerontol.
PD MAR
PY 2019
VL 117
SI SI
BP 76
EP 90
DI 10.1016/j.exger.2018.11.012
PG 15
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA HK7AF
UT WOS:000458137300011
PM 30458224
DA 2025-06-11
ER

PT J
AU Zinellu, A
   Mangoni, AA
AF Zinellu, Angelo
   Mangoni, Arduino A.
TI Effect of statin treatment on homocysteine concentrations: an updated
   systematic review and meta-analysis with meta-regression
SO EXPERT REVIEW OF CLINICAL PHARMACOLOGY
LA English
DT Review
DE statins; homocysteine; atherosclerosis
ID ENHANCES ENDOTHELIAL FUNCTION; ENDOPLASMIC-RETICULUM STRESS;
   CARDIOMETABOLIC RISK-FACTORS; INTIMA-MEDIA THICKNESS; FOLIC-ACID;
   ASYMMETRIC DIMETHYLARGININE; CARDIOVASCULAR-DISEASE; PLASMA
   HOMOCYSTEINE; CAROTID ATHEROSCLEROSIS; COMBINED HYPERLIPIDEMIA
AB Background and aims Statins might exert atheroprotective effects through lowering the pro-atherogenic amino acid homocysteine. We conducted an updated systematic review and meta-analysis of the effect of statins on circulating homocysteine. Methods A systematic literature search was conducted in PubMed, Web of Science, and Scopus, from inception to July 2021. The risk of bias was assessed using the Joanna Briggs Institute Critical Appraisal Checklist for analytical studies. Certainty of evidence was assessed using GRADE. Results In 61 treatment arms in 2,218 patients (mean age 55 years, 52% males), statins significantly reduced homocysteine concentrations (weighted mean difference, WMD = -2.46 mu mol/L, 95% CI -3.17 to -1.75 mu mol/L, p < 0.001; high certainty of evidence). Similar results were observed in a subgroup of 10 randomized placebo-controlled studies (WMD = -2.45 mu mol/L, 95% CI -4.43 to -0.47 mu mol/L, p = 0.015). The extreme heterogeneity observed was virtually removed in a subgroup of 10 studies using fluorescence polarization immunoassay for homocysteine measurement. There was no publication bias. In sensitivity analysis, the pooled WMD values were not modified when individual studies were sequentially removed. In meta-regression, the WMD was significantly associated with proportion of males and publication year. Conclusions Statins significantly lower homocysteine concentrations.
C1 [Zinellu, Angelo] Univ Sassari, Dept Biomed Sci, Sassari, Italy.
   [Mangoni, Arduino A.] Flinders Univ S Australia, Coll Med & Publ Hlth, Discipline Clin Pharmacol, Adelaide, SA, Australia.
   [Mangoni, Arduino A.] Southern Adelaide Local Hlth Network, Dept Clin Pharmacol, Flinders Med Ctr, Adelaide, SA, Australia.
C3 University of Sassari; Flinders University South Australia; Flinders
   Medical Centre
RP Mangoni, AA (corresponding author), Flinders Univ S Australia, Coll Med & Publ Hlth, Dept Clin Pharmacol, Bedford Pk, SA 5042, Australia.; Mangoni, AA (corresponding author), Flinders Med Ctr, Bedford Pk, SA 5042, Australia.
EM arduino.mangoni@flinders.edu.au
RI Mangoni, Arduino/F-8000-2010
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NR 99
TC 2
Z9 3
U1 0
U2 7
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1751-2433
EI 1751-2441
J9 EXPERT REV CLIN PHAR
JI Expert Rev. Clin. Pharmacol.
PD APR 3
PY 2022
VL 15
IS 4
BP 443
EP 459
DI 10.1080/17512433.2022.2072293
EA MAY 2022
PG 17
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 3P4AL
UT WOS:000791848600001
PM 35482022
DA 2025-06-11
ER

PT J
AU Das, A
AF Das, Aniruddha
TI Loneliness does (not) have cardiometabolic effects: A longitudinal study
   of older adults in two countries
SO SOCIAL SCIENCE & MEDICINE
LA English
DT Article
DE Loneliness; Blood pressure; HbA1c; Older adults; HRS; ELSA
ID CROSS-LAGGED ANALYSES; SOCIAL-ISOLATION; HEALTH BEHAVIOR; TELOMERE
   LENGTH; COHORT PROFILE; SELECTION BIAS; RISK-FACTORS; LIFE-SPAN; STRESS;
   AGE
AB Objectives: Mass media increasingly report a "loneliness epidemic." A growing academic literature claims downstream effects of this experience on surrogate markers of cardiometabolic risk. Evidence on such influences is based on flawed samples and methodologies, rendering inferences questionable. The current study tested these claims.
   Methods: Analysis was based on three-wave data on older adults from two national probability samples-the U.S. Health and Retirement Study (HRS) and the English Longitudinal Study of Ageing (ELSA). Models were gender-differentiated. Cardiovascular states were indexed by systolic and diastolic blood pressure, and metabolic condition by hemoglobin A1c. Fixed effects models were used for initial investigation, and subsequent triangulation was through a first-differencing approach with instrumental variables.
   Results: Loneliness had no linkage with any of the three outcomes. Nor were prevalences indicative of an epidemic of this affective state. Both gender and cross-national variations emerged: women were lonelier than men in each sample, while ELSA participants of both genders were less so than their HRS counterparts.
   Discussion: Contra previous literature, loneliness may not have cardiometabolic implications. Such nonreplications are increasingly common in the emerging "biosocial science" literature. Potential sources are discussed. More rigorous methods are available and urgently need incorporation to root out flawed inferences and conceptual models.
C1 [Das, Aniruddha] McGill Univ, Dept Sociol, Room 712,Leacock Bldg,855 Sherbrooke St West, Montreal, PQ H3A 2T7, Canada.
C3 McGill University
RP Das, A (corresponding author), McGill Univ, Dept Sociol, Room 712,Leacock Bldg,855 Sherbrooke St West, Montreal, PQ H3A 2T7, Canada.
EM aniruddha.das@mcgill.ca
FU National Institute on Aging [NIA U01AG009740]; National Institute on
   Aging [U01AG009740] Funding Source: NIH RePORTER
FX The HRS is sponsored by the National Institute on Aging (grant number
   NIA U01AG009740) and is conducted by the University of Michigan. The
   author thanks the editor and two anonymous reviewers for their thorough
   and insightful comments.
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NR 80
TC 23
Z9 27
U1 0
U2 17
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0277-9536
EI 1873-5347
J9 SOC SCI MED
JI Soc. Sci. Med.
PD FEB
PY 2019
VL 223
BP 104
EP 112
DI 10.1016/j.socscimed.2018.10.021
PG 9
WC Public, Environmental & Occupational Health; Social Sciences, Biomedical
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; Biomedical Social Sciences
GA HO2BD
UT WOS:000460715500013
PM 30487051
DA 2025-06-11
ER

PT J
AU Benjamin, D
   Swartz, M
   Forman, L
AF Benjamin, Dinesh
   Swartz, Marvin
   Forman, Leslie
TI The Impact of Evidence-Based Education on Prescribing in a Psychiatry
   Residency
SO JOURNAL OF PSYCHIATRIC PRACTICE
LA English
DT Article
DE prescribing patterns; psychotropic medications; antipsychotics; generic
   medications; psychiatric residents; residency training
ID RANDOMIZED CONTROLLED-TRIAL; 2ND-GENERATION ANTIPSYCHOTICS;
   CHRONIC-SCHIZOPHRENIA; COST-EFFECTIVENESS; DRUGS; MEDICATIONS; POLICY
AB Objective. Recent clinical trials comparing the effectiveness of antipsychotics have found no advantage for second-generation antipsychotics over older first-generation agents. However, the former are much more commonly used despite their significantly higher cost and potential for contributing to the metabolic syndrome. To date, educational interventions have been unsuccessful in influencing this pattern. The Duke University Medical Center Department of Psychiatry began a program based on principles of academic detailing designed to educate psychiatry residents about generic psychotropics. To encourage residents to gain experience with these medications, samples of selected generic drugs were provided. To assess the initiative's impact, the authors measured the prescribing patterns of residents. Methods. We measured the amount of generic drug use 6 months after the program began and compared it with data from a 6-month control period. The data were analyzed based on overall psychotropic use, class of medication, site, and diagnosis. Results. We found a consistent increase in generic use across analyses. There was an increase in overall generic prescribing from 55.8% to 58.6% (chi(2) = 10.37, odds ratio [OR] = 1.12, p = 0.0013) and a particularly large increase in prescribing of generic antipsychotic medications from 39.5% to 47.7% (chi(2) = 36.12, OR = 1.39, p < 0.0001). Conclusion. The implementation of this educational program was correlated with increasing use of generic medications and brought antipsychotic prescribing into concordance with the new evidence. This is the first such study in a psychiatry residency program and has implications for promoting cost-effective care while preserving patient choice in the mental health system. The findings from this study also suggest potential techniques for expanding residents' prescribing skills across specialties. (Journal of Psychiatric Practice 2011; 17: 110-117)
C1 [Benjamin, Dinesh; Swartz, Marvin; Forman, Leslie] Duke Univ, Med Ctr, Durham, NC USA.
C3 Duke University
RP Benjamin, D (corresponding author), 4404 Dula St, Durham, NC 27705 USA.
EM dineshbenjamin@gmail.com
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NR 19
TC 9
Z9 9
U1 0
U2 10
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1527-4160
EI 1538-1145
J9 J PSYCHIATR PRACT
JI J. Psychiatr. Pract.
PD MAR
PY 2011
VL 17
IS 2
BP 110
EP 117
DI 10.1097/01.pra.0000396062.12893.5b
PG 8
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 739TO
UT WOS:000288741200005
PM 21430489
OA Bronze
DA 2025-06-11
ER

PT J
AU Mangurian, C
   Newcomer, JW
   Modlin, C
   Schillinger, D
AF Mangurian, Christina
   Newcomer, John W.
   Modlin, Chelsea
   Schillinger, Dean
TI Diabetes and Cardiovascular Care Among People with Severe Mental
   Illness: A Literature Review
SO JOURNAL OF GENERAL INTERNAL MEDICINE
LA English
DT Review
DE mental illness; diabetes; integration of care
ID RANDOMIZED CONTROLLED-TRIAL; CATIE SCHIZOPHRENIA TRIAL; METABOLIC
   SYNDROME; ANTIPSYCHOTIC MEDICATIONS; NATIONAL-HEALTH; DISEASE RISK;
   WEIGHT-LOSS; FOLLOW-UP; PREVALENCE; US
AB Close to 19 million US adults have severe mental illnesses (SMI), and they die, on average, 25 years earlier than the general population, most often from cardiovascular disease (CVD). Many of the antipsychotic medications used to treat SMI contribute to CVD risk by increasing risk for obesity, type 2 diabetes, dyslipidemia, and hypertension. Based on compelling evidence, the American Diabetes Association and the American Psychiatric Association developed guidelines for metabolic screening and monitoring during use of these medications.
   In this manuscript, we have reviewed the evidence on diabetes and other CVD risk screening, prevalence, and management among populations with SMI. We also review differences in screening among subpopulations with SMI (e.g., racial/ethnic minorities, women, and children). We found that despite national guidelines for screening for diabetes and other cardiovascular risk factors, up to 70 % of people taking antipsychotics remain unscreened and untreated. Based on estimates that 20 % of the 19 million US adults with SMI have diabetes and 70 % of them are not screened; it is likely that over 2 million Americans with SMI have unidentified diabetes. Given that undiagnosed diabetes costs over $4,000 per person, this failure to identify diabetes among people with SMI represents a missed opportunity to prevent morbidity and translates to over $8 billion in annual preventable costs to our healthcare system.
   Given the high burden of disease and significant evidence of suboptimal medical care received by people with SMI, we propose several clinical and policy recommendations to improve diabetes and other CVD risk screening and care for this highly vulnerable population. These recommendations include reducing antipsychotic medication dose or switching antipsychotic medications, enhancing smoking cessation efforts, sharing electronic health records between physical and mental health care systems, and promoting integration of care.
C1 [Mangurian, Christina] Univ Calif San Francisco, Dept Psychiat, San Francisco, CA USA.
   [Mangurian, Christina; Schillinger, Dean] UCSF Ctr Vulnerable Populat ZSFG, San Francisco, CA USA.
   [Mangurian, Christina; Schillinger, Dean] Zuckerberg San Francisco Gen, San Francisco, CA 94110 USA.
   [Newcomer, John W.] Florida Atlantic Univ, Boca Raton, FL 33431 USA.
   [Modlin, Chelsea] Dartmouth Coll, Geisel Sch Med, Hanover, NH USA.
   [Schillinger, Dean] UCSF Dept Med, San Francisco, CA USA.
C3 University of California System; University of California San Francisco;
   State University System of Florida; Florida Atlantic University;
   Dartmouth College
RP Mangurian, C (corresponding author), Zuckerberg San Francisco Gen, San Francisco, CA 94110 USA.
EM christina.mangurian@ucsf.edu
OI Modlin, Chelsea/0000-0001-9005-9812; Newcomer, John/0000-0003-2153-9382
FU National Institutes of Mental Health [1K23MH093689]; UCSF Hellman
   Fellows Award for Early-Career Faculty; National Center for Research
   Resources; National Center for Advancing Translational Sciences; Office
   of the Director, National Institutes of Health, through UCSF-CTSI [KL2
   RR024130]; National Institutes of Health; Otsuka America Pharmaceutical
   Inc.; Foundation2Recovery; Reviva Pharmaceuticals; NIH Center [P30
   DK092924-01]; NIH Center Grant from the National Institute of Diabetes
   and Digestive and Kidney Diseases for The Health Delivery Systems-Center
   for Diabetes Translational Research (CDTR) [P30DK092924]; NIH/National
   Institute of Minority Health and Health Disparities (NIMHD)
   Comprehensive Center of Excellence for Health and Risk in Minority Youth
   and Young Adults [P60MD006902]; National Institute of Diabetes and
   Digestive and Kidney Diseases [P30DK098722] Funding Source: NIH RePORTER
FX Dr. Mangurian was supported by the National Institutes of Mental Health
   (1K23MH093689), the UCSF Hellman Fellows Award for Early-Career Faculty,
   and the National Center for Research Resources, the National Center for
   Advancing Translational Sciences, and the Office of the Director,
   National Institutes of Health, through UCSF-CTSI Grant Number KL2
   RR024130. Dr. Newcomer has received grant support from the National
   Institutes of Health, Otsuka America Pharmaceutical Inc. and
   Foundation2Recovery, consulting fees from Reviva Pharmaceuticals, and he
   serves on a Data Safety Monitoring Board for Amgen, outside the
   submitted work. Dr. Schillinger was supported by NIH Center grants P30
   DK092924-01. Dr. Schillinger was supported by the NIH Center Grant from
   the National Institute of Diabetes and Digestive and Kidney Diseases for
   The Health Delivery Systems-Center for Diabetes Translational Research
   (CDTR) (P30DK092924) and the NIH/National Institute of Minority Health
   and Health Disparities (NIMHD) Comprehensive Center of Excellence for
   Health and Risk in Minority Youth and Young Adults (P60MD006902). Its
   contents are solely the responsibility of the authors and do not
   necessarily represent the official views of NIH.
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NR 113
TC 66
Z9 75
U1 2
U2 25
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0884-8734
EI 1525-1497
J9 J GEN INTERN MED
JI J. Gen. Intern. Med.
PD SEP
PY 2016
VL 31
IS 9
BP 1083
EP 1091
DI 10.1007/s11606-016-3712-4
PG 9
WC Health Care Sciences & Services; Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services; General & Internal Medicine
GA DT6NJ
UT WOS:000381600700023
PM 27149967
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Zou, CF
   Sun, HM
   Lu, CY
   Chen, WQ
   Guo, VY
AF Zou, Chenfeng
   Sun, Huimin
   Lu, Ciyong
   Chen, Weiqing
   Guo, Vivian Yawei
TI Nighttime sleep duration, restlessness and risk of multimorbidity-A
   longitudinal study among middle-aged and older adults in China
SO ARCHIVES OF GERONTOLOGY AND GERIATRICS
LA English
DT Article
DE Sleep duration; Restlessness; Multimorbidity; Chinese; Longitudinal
   study
ID C-REACTIVE PROTEIN; CHRONIC DISEASES; METABOLIC SYNDROME; MENTAL-HEALTH;
   LIFE-STYLE; HPA AXIS; ASSOCIATION; QUALITY; INTERLEUKIN-6; INFLAMMATION
AB Purpose: To assess the associations of nighttime sleep duration and restlessness with the risk of multimorbidity in Chinese middle-aged and older adults. Methods: We used the 2011 and 2015 surveys of the China Health and Retirement Longitudinal Study (CHARLS). Sleep duration was grouped into 5, (5-6], (6-8], (8-9], and 9 h/night. Restlessness days in the past week were categorized into < 1, 1-2, 3-4, and 5-7 days/week. Multimorbidity was defined as the co-existence of two or more of 14 chronic conditions (hypertension, dyslipidemia, diabetes mellitus, cancer, chronic lung disease, liver disease, heart problems, stroke, kidney disease, digestive disease, psychiatric problems, memory-related disease, arthritis, and asthma). Log-binomial regression models were used to estimate the associations. Results: A total of 6,037 participants free of multimorbidity at baseline were included. During four-years of follow-up, 2,203 (36.5%) participants developed multimorbidity. Compared to participants who slept 6-8 h/ night, those with short sleep duration < 5 h/night and 5-6 h/night were associated with 33.3% (95% CI: 14.8%54.7%) and 24.2% (95% CI: 5.9%-45.6%) increased risk of multimorbidity, respectively. Long sleep duration was not significantly associated with incident multimorbidity. Compared to those who rarely or never had a restless sleep in the past week, participants with 5-7 days of restless sleep had increased risk of multimorbidity (RR: 1.750, 95% CI: 1.476-2.076). Similar findings were confirmed in subgroups by age, gender, and baseline chronic condition status. Conclusions: Short nighttime sleep duration and restlessness were associated with increased risk of multimorbidity in China.
C1 [Zou, Chenfeng; Sun, Huimin; Lu, Ciyong; Chen, Weiqing; Guo, Vivian Yawei] Sun Yat Sen Univ, Sch Publ Hlth, Dept Epidemiol, 74 Zhongshan Second Rd, Guangzhou 510080, Guangdong, Peoples R China.
C3 Sun Yat Sen University
RP Guo, VY (corresponding author), Sun Yat Sen Univ, Sch Publ Hlth, Dept Epidemiol, 74 Zhongshan Second Rd, Guangzhou 510080, Guangdong, Peoples R China.
EM guoyw23@mail.sysu.edu.cn
RI Guo, Vivian/ABB-5803-2022; Zou, Chenfeng/HPD-8411-2023
OI Guo, Vivian Yawei/0000-0001-9399-1808; Zou, Chenfeng/0000-0001-7146-9605
FU Sun Yat-sen University [51000-18841211]; Guangdong Basic and Applied
   Basic Research Foundation [2019A1515110571, 2021A1515010906]
FX This research was funded by the start-up fund from the Sun Yat-sen
   University [grant number 51000-18841211]; the Guangdong Basic and
   Applied Basic Research Foundation [grant number 2019A1515110571 and
   2021A1515010906].
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NR 48
TC 19
Z9 20
U1 2
U2 26
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0167-4943
EI 1872-6976
J9 ARCH GERONTOL GERIAT
JI Arch. Gerontol. Geriatr.
PD JAN-FEB
PY 2022
VL 98
AR 104580
DI 10.1016/j.archger.2021.104580
EA NOV 2021
PG 7
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA XM0YK
UT WOS:000728562500004
PM 34837791
DA 2025-06-11
ER

PT J
AU Wagner, S
   Addington, KS
   Varming, A
   Hempler, NF
AF Wagner, Sabina
   Addington, Kristine Stoltenberg
   Varming, Annemarie
   Hempler, Nana Folmann
TI Caught between good intentions and rigid structures: A qualitative
   description of professionals' experiences with health promotion in
   mental health services
SO SCANDINAVIAN JOURNAL OF CARING SCIENCES
LA English
DT Article
DE collaborative care; health promotion; integrated care; mental illness;
   organisational health literacy; professional philosophies
ID LIFE-STYLE INTERVENTIONS; PATIENT EMPOWERMENT; METABOLIC SYNDROME;
   PEOPLE; ILLNESS; SCHIZOPHRENIA; INTERVIEWS; CHALLENGE; DISORDERS;
   EDUCATION
AB Background and aim Compared with the general population, people with mental illness are at higher risk of developing type 2 diabetes due to poor diet, medication and inactive lifestyle. People with mental illness and members of the general population are equally interested in health behaviour change, but those with mental illness experience communication barriers with professionals. The study aimed to explore philosophies that social care and healthcare professionals apply to health promotion activities targeting people with mental illness and challenges they face in applying these philosophies across multiple settings. Methods Qualitative interviews were conducted with 18 social and healthcare professionals in a range of settings in 2016-2019. Descriptive qualitative analysis was applied to interview data. Results Interviewees faced many structural challenges in the organisation of their work, which did not coincide with their philosophy or intentions in relation to health promotion. Three philosophical categories were identified: (a) health promotion approach, (b) elements of care and (c) social relations. Many interviewees intended to apply philosophies of broadly defined health, dialogue-based health education, and incremental approaches to health behaviour change. They wanted to provide holistic and flexible care and they valued peer-to-peer activities, family and friend involvement in care and a trusting relationship between the professional and the person with mental illness. However, rigid structures determining the organisation of health promotion challenged professionals' ability to follow their philosophical intentions. Conclusion Interviewees aspired to a collaborative, empowering and person-centred approach, but practical and structural factors made this difficult to achieve in practice. Major changes are required at the organisational level, implemented with the active involvement of professionals and people with mental illness.
C1 [Wagner, Sabina; Addington, Kristine Stoltenberg; Varming, Annemarie; Hempler, Nana Folmann] Steno Diabet Ctr Copenhagen, Hlth Promot Res, Gentofte, Denmark.
C3 Steno Diabetes Center
RP Addington, KS (corresponding author), Steno Diabet Ctr Copenhagen, Niels Steensens Vej 6, DK-2820 Gentofte, Denmark.
EM kristine.stoltenberg.addington@regionh.dk
RI varming, annemarie/JSL-3522-2023
OI Hempler, Nana Folmann/0009-0001-9968-3598; Wagner,
   Sabina/0000-0001-6147-2181; Addington, Kristine
   Stoltenberg/0000-0003-4352-3445; Varming, Annemarie/0000-0003-2642-7603
CR Ahmad N., 2014, Person-centred care: From ideas to action
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NR 36
TC 1
Z9 1
U1 0
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0283-9318
EI 1471-6712
J9 SCAND J CARING SCI
JI Scand. J. Caring Sci.
PD SEP
PY 2022
VL 36
IS 3
BP 663
EP 672
DI 10.1111/scs.13023
EA AUG 2021
PG 10
WC Nursing
WE Social Science Citation Index (SSCI)
SC Nursing
GA 4C9FC
UT WOS:000681475900001
PM 34355422
DA 2025-06-11
ER

PT J
AU Hsieh, MH
   Tang, CH
   Hsieh, MH
   Lee, IH
   Lai, TJ
   Lin, YJ
   Yang, YK
AF Hsieh, Ming Hong
   Tang, Chao-Hsiun
   Hsieh, Ming H.
   Lee, I. Hui
   Lai, Te Jen
   Lin, Yung-Jung
   Yang, Yen Kuang
TI Medical costs and vasculometabolic comorbidities among patients with
   bipolar disorder in Taiwan - A population-based and matched-control
   study
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Bipolar disorder; Non-psychiatric medical cost; Total medical cost;
   Vasculometabolic comorbidity
ID HEALTH-CARE UTILIZATION; METABOLIC SYNDROME; ATYPICAL ANTIPSYCHOTICS;
   RESOURCE UTILIZATION; DIABETES-MELLITUS; INCREASED RISK; MENTAL-HEALTH;
   PREVALENCE; MOOD; BURDEN
AB Background: Bipolar disorder (BD) is a costly disease with a high rate of vasculometabolic comorbidities. The aims of this study were to explore the 1-year treatment cost, including total medical and non-psychiatric services, and the prevalence of vasculometabolic comorbidities in individuals with BD.
   Methods: A nationwide population-based dataset, covering the years 2006 and 2007, was obtained from the Taiwan National Health Insurance claims database. The study sample comprised patients discharged from hospitals between 1 January 2006 and 31 December 2007. Annual non-psychiatric and total medical costs and vasculometabolic comorbidities were examined. Generalized linear models were used to examine the medical costs, and conditional logistic regression analyses were carried out to test the prevalence of vasculometabolic comorbidities in people with BD and to compare this with that found in matched controls.
   Results: The total medical cost was 11-fold higher (New Taiwan [NT] $227,040 vs. NT$20,461), and the non-psychiatric medical cost was 1.7-fold higher (NT$33,173 vs. NT$19,406) with regard to the individuals with BD vs. the matched controls. The prevalence of vasculometabolic comorbidities was significantly higher in the individuals with BD than in the controls (ratio ranging from 1.86 to 4.06).
   Conclusions: Both the non-psychiatric healthcare utilization and the prevalence of vasculometabolic comorbidities are higher with regard to individuals with BD vs. their matched controls. Therefore, treatment of BD should integrate medical and psychiatric care to decrease the impact of medical comorbidities, which may also decrease the overall medical cost. (C) 2012 Elsevier B. V. All rights reserved.
C1 [Lai, Te Jen] Chung Shan Med Univ Hosp, Inst Med, Dept Psychiat, Taichung 402, Taiwan.
   [Hsieh, Ming Hong; Lai, Te Jen] Chung Shan Med Univ, Inst Med, Taichung, Taiwan.
   [Lee, I. Hui; Yang, Yen Kuang] Natl Cheng Kung Univ Hosp, Dept Psychiat, Tainan 70428, Taiwan.
   [Tang, Chao-Hsiun] Taipei Med Univ, Sch Hlth Care Adm, Taipei, Taiwan.
   [Tang, Chao-Hsiun] Taipei Med Univ Hosp, Gynecol Res Ctr, Taipei, Taiwan.
   [Hsieh, Ming H.] Natl Taiwan Univ Hosp, Dept Psychiat, Taipei, Taiwan.
   [Lee, I. Hui; Yang, Yen Kuang] Natl Cheng Kung Univ, Coll Med, Dept Psychiat, Tainan 70101, Taiwan.
   [Lee, I. Hui; Yang, Yen Kuang] Natl Cheng Kung Univ, Addict Res Ctr, Tainan 70101, Taiwan.
   [Lin, Yung-Jung] Janssen Cilag Taiwan, Div Corp Commun & Govt Affairs, Taipei, Taiwan.
C3 Chung Shan Medical University; Chung Shan Medical University Hospital;
   Chung Shan Medical University; National Cheng Kung University; National
   Cheng Kung University Hospital; Taipei Medical University; Taipei
   Medical University Hospital; Taipei Medical University; National Taiwan
   University; National Taiwan University Hospital; National Cheng Kung
   University; National Cheng Kung University; Johnson & Johnson; Johnson &
   Johnson Taiwan
RP Lai, TJ (corresponding author), Chung Shan Med Univ Hosp, Inst Med, Dept Psychiat, 110,Sec 1,Jianguo N Rd, Taichung 402, Taiwan.
EM tejenlai@hotmail.com; ykyang@mail.ncku.edu.tw
RI Chen, Hsing-yu/C-3979-2011; Hsieh, Ming H./B-2970-2010
OI Hsieh, Ming H./0000-0002-3585-7843
FU Janssen-Cilag (Taiwan) [Teh-Tzer B1001010]
FX The authors extend their sincere appreciation to Janssen-Cilag (Taiwan)
   for funding this research.The authors wish to thank Chien Ting Lin and
   Sheng-Tzu Hung for their administrative support. The financial support
   provided for this research by Janssen-Cilag (Taiwan), Teh-Tzer B1001010,
   is gratefully acknowledged. It should be emphasized that the authors
   retained total independence in the preparation of this manuscript.
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NR 53
TC 12
Z9 12
U1 0
U2 7
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD DEC 10
PY 2012
VL 141
IS 2-3
BP 449
EP 456
DI 10.1016/j.jad.2012.02.038
PG 8
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA 039IF
UT WOS:000311237700042
PM 22460055
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Goodrich, DE
   Kilbourne, AM
   Lai, ZS
   Post, EP
   Bowersox, NW
   Mezuk, B
   Schumacher, K
   Bramlet, M
   Welsh, DE
   Bauer, MS
AF Goodrich, David E.
   Kilbourne, Amy M.
   Lai, Zongshan
   Post, Edward P.
   Bowersox, Nicholas W.
   Mezuk, Briana
   Schumacher, Karen
   Bramlet, Margretta
   Welsh, Deborah E.
   Bauer, Mark S.
TI Design and rationale of a randomized controlled trial to reduce
   cardiovascular disease risk for patients with bipolar disorder
SO CONTEMPORARY CLINICAL TRIALS
LA English
DT Article
DE Bipolar disorder; Cardiovascular disease; Collaborative care; Physical
   activity; Nutrition; Serious mental illness
ID GENERAL-MEDICAL CONDITIONS; SERIOUS MENTAL-ILLNESS; LONG-TERM
   EFFECTIVENESS; CORONARY-HEART-DISEASE; QUALITY-OF-LIFE; COLLABORATIVE
   CARE; ATHEROSCLEROSIS RISK; PSYCHIATRIC OUTCOMES; ANTIPSYCHOTIC-DRUGS;
   METABOLIC SYNDROME
AB Background: Persons with bipolar disorder (BD) experience a disproportionate burden of medical comorbidity, notably cardiovascular disease (CVD), contributing to decreased function and premature mortality. We describe the design, rationale, and baseline findings for the Self-Management Addressing Heart Risk Trial (SMAHRT), a randomized controlled effectiveness trial of an intervention (Life Goals Collaborative Care; LGCC) designed to reduce CVD risk factors and improve physical and mental health outcomes in patients with BD.
   Methods: Patients with BD and at least one CVD risk factor were recruited from a VA healthcare system and randomized to either LGCC or usual care (UC). LGCC participants attended four weekly, group-based self-management sessions followed by monthly individual contacts supportive of health behavior change and ongoing medical care management. In contrast, UC participants received monthly wellness newsletters. Physiological and questionnaire assessments measured changes in CVD outcomes and quality of life (QOL) over 24 months.
   Results: Out of the 180 eligible patients. 134 patients were enrolled (74%) and 118 started the study protocols. At baseline (mean age = 54, 17% female, 5% African American) participants had a high burden of clinical risk with nearly 70% reporting at least three CVD risk factors including, smoking (41%) and physical inactivity (57%). Mean mental and physical HRQOL scores were 1.5 SD below SF-12 population averages.
   Conclusion: SMAHRT participants experienced substantial CVD morbidity and risk factors, poor symptom control, and decreased QOL LGCC is the first integrated intervention for BD designed to mitigate suboptimal health outcomes by combining behavioral medicine and care management strategies. Published by Elsevier Inc.
C1 [Goodrich, David E.; Kilbourne, Amy M.; Lai, Zongshan; Post, Edward P.; Bowersox, Nicholas W.; Schumacher, Karen; Bramlet, Margretta; Welsh, Deborah E.] VA Ann Arbor Ctr Clin Management Res, Ann Arbor, MI 48105 USA.
   [Goodrich, David E.; Kilbourne, Amy M.; Lai, Zongshan] Univ Michigan, Sch Med, Dept Psychiat, Ann Arbor, MI 48109 USA.
   [Post, Edward P.] Univ Michigan, Sch Med, Dept Internal Med, Taubman Ctr 3110,SPC 5368, Ann Arbor, MI 48109 USA.
   [Mezuk, Briana] Virginia Commonwealth Univ, Dept Epidemiol & Community Hlth, Richmond, VA 23298 USA.
   [Bauer, Mark S.] VA Boston Healthcare Syst 152M, Ctr Org Leadership & Management Res, Boston, MA 02130 USA.
   [Bauer, Mark S.] Harvard Univ, Sch Med, Dept Psychiat, Boston, MA 02215 USA.
C3 University of Michigan System; University of Michigan; University of
   Michigan System; University of Michigan; Virginia Commonwealth
   University; Harvard University; Harvard Medical School
RP Kilbourne, AM (corresponding author), VA Ann Arbor Ctr Clin Management Res, 2215 Fuller Rd,Mail Stop 152, Ann Arbor, MI 48105 USA.
EM David.Goodrich2@va.gov; amykilbo@umich.edu; Zongshan.Lai@va.gov;
   Edward.Post@va.gov; Nicholas.Bowersox@va.gov; bmezuk@vcu.edu;
   Karen.Schumacher@va.gov; Margretta.Bramlet@va.gov; Deborah.Welsh@va.gov;
   Mark.Bauer@va.gov
RI Mezuk, Briana/AAY-5321-2020
OI Goodrich, David/0000-0003-3232-2189; Bowersox,
   Nicholas/0000-0001-9867-4326; Post, Edward/0000-0002-5782-8736; Mezuk,
   Briana/0000-0003-1798-2285
FU Department of Veterans Affairs, Veterans Health Administration, Clinical
   Sciences Research and Development [CSRD S06]; VA Health Services
   Research and Development Center for Organization, Leadership, and
   Management Research (COLMR); National Institute of Mental Health
   [R34MH74509]
FX This work was supported by the Department of Veterans Affairs, Veterans
   Health Administration, Clinical Sciences Research and Development [CSRD
   S06], the VA Health Services Research and Development Center for
   Organization, Leadership, and Management Research (COLMR), and the
   National Institute of Mental Health [R34MH74509]. The views expressed in
   this article are those of the authors and do not necessarily represent
   the views of the Department of Veterans Affairs.
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NR 83
TC 15
Z9 17
U1 0
U2 9
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1551-7144
EI 1559-2030
J9 CONTEMP CLIN TRIALS
JI Contemp. Clin. Trials
PD JUL
PY 2012
VL 33
IS 4
BP 666
EP 678
DI 10.1016/j.cct.2012.02.010
PG 13
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA 964QL
UT WOS:000305711700017
PM 22386799
DA 2025-06-11
ER

PT J
AU Kerba, J
   Demers, C
   Bélanger, V
   Napartuk, M
   Bouchard, I
   Meloche, C
   Morel, S
   Prud'homme, N
   Gélinas, I
   Higgins, J
   Curnier, D
   Sultan, S
   Laverdière, C
   Sinnett, D
   Marcil, V
AF Kerba, Johanne
   Demers, Catherine
   Belanger, Veronique
   Napartuk, Melanie
   Bouchard, Isabelle
   Meloche, Caroline
   Morel, Sophia
   Prud'homme, Nicolas
   Gelinas, Isabelle
   Higgins, Johanne
   Curnier, Daniel
   Sultan, Serge
   Laverdiere, Caroline
   Sinnett, Daniel
   Marcil, Valerie
TI Needs, Barriers and Facilitators of Adolescents Participating in a
   Lifestyle Promotion Program in Oncology: Stakeholders, Adolescents and
   Parents' Perspective
SO CHILDREN-BASEL
LA English
DT Article
DE adolescent; cancer; health promotion intervention; nutrition; physical
   activity; mental health; needs; barriers; facilitators; lifestyle
ID ACUTE LYMPHOBLASTIC-LEUKEMIA; YOUNG-ADULT CANCER; CHILDHOOD-CANCER;
   HEALTH-CARE; METABOLIC SYNDROME; DIETARY-INTAKE; DELPHI PANEL;
   SURVIVORS; CHILDREN; SERVICES
AB Treatments for adolescent cancer can cause debilitating side effects in the short- and long-term such as nausea and malnutrition but also cardiometabolic disturbances. Although the risk for cardiometabolic complications is greater for adolescents with cancer than younger ones, adolescents typically respond poorly to family-oriented health promotion programs. This study aims to assess the needs, barriers and facilitators to healthy lifestyle promotion interventions for adolescents with cancer and how to best adapt these interventions for them. Interviews were held with adolescents treated for cancer (n = 9) and parents (n = 6), focus groups were conducted with stakeholders working in oncology (n = 12) and self-report questionnaires were sent to stakeholders involved in a health promotion intervention (n = 6). At the time of interview, mean age of adolescent participants (40% female) was 17.0 +/- 1.9 years (mean age at diagnosis: 14.6 +/- 1.6 years). Verbatim and responses to questionnaires were coded and analyzed using qualitative methods. Stakeholder stated that adolescents with cancer need to access activities adapted to their age, to communicate with peers going through a similar experience, and to preserve their schooling and friendships. Barriers to intervention reported by adolescents, parents and stakeholders include lack of motivation, schedule conflicts, fatigue and treatment side effects. Some of the barriers mentioned by adolescents and parents include pain, post-surgery problems, school, physical deconditioning, and lack of time. Facilitators mentioned by adolescents and parents comprise trust in stakeholders' expertise, personalized approaches, scheduling flexibility. Stakeholders recommended to build trust in the relationship, favoring non-moralizing teachings, adapt interventions to adolescents' limited attention span and avoiding the use of long-term health benefits as a motivator.
C1 [Kerba, Johanne; Demers, Catherine; Belanger, Veronique; Napartuk, Melanie; Bouchard, Isabelle; Meloche, Caroline; Morel, Sophia; Curnier, Daniel; Sultan, Serge; Laverdiere, Caroline; Sinnett, Daniel; Marcil, Valerie] CHU St Justine, Res Ctr, Montreal, PQ H3T 1C5, Canada.
   [Kerba, Johanne; Belanger, Veronique; Napartuk, Melanie; Morel, Sophia; Marcil, Valerie] Univ Montreal, Dept Nutr, Montreal, PQ H3T 1A8, Canada.
   [Kerba, Johanne; Belanger, Veronique; Napartuk, Melanie; Morel, Sophia; Marcil, Valerie] Cardiometab Hlth Diabet & Obes Res Network CMDO, Montreal, PQ J1H 5N4, Canada.
   [Demers, Catherine; Gelinas, Isabelle] McGill Univ, Sch Phys & Occupat Therapy, Montreal, PQ H3G 1Y5, Canada.
   [Belanger, Veronique; Napartuk, Melanie; Morel, Sophia; Marcil, Valerie] Inst Nutr & Funct Food, Quebec City, PQ G1V 0A6, Canada.
   [Prud'homme, Nicolas] CHU St Justine, Div Hematol Oncol, Montreal, PQ H3T 1C5, Canada.
   [Higgins, Johanne] Univ Montreal, Sch Rehabil, Montreal, PQ H3N 1X7, Canada.
   [Curnier, Daniel] Univ Montreal, Sch Kinesiol & Phys Act Sci, Montreal, PQ H3T 1J4, Canada.
   [Sultan, Serge] Univ Montreal, Dept Psychol, Montreal, PQ H3C 3J7, Canada.
   [Laverdiere, Caroline; Sinnett, Daniel] Univ Montreal, Dept Pediat, Montreal, PQ H3T 1C5, Canada.
C3 Universite de Montreal; Centre Hospitalier Universitaire Sainte-Justine;
   Universite de Montreal; McGill University; Universite de Montreal;
   Centre Hospitalier Universitaire Sainte-Justine; Universite de Montreal;
   Universite de Montreal; Universite de Montreal; Universite de Montreal
RP Marcil, V (corresponding author), CHU St Justine, Res Ctr, Montreal, PQ H3T 1C5, Canada.; Marcil, V (corresponding author), Univ Montreal, Dept Nutr, Montreal, PQ H3T 1A8, Canada.; Marcil, V (corresponding author), Cardiometab Hlth Diabet & Obes Res Network CMDO, Montreal, PQ J1H 5N4, Canada.; Marcil, V (corresponding author), Inst Nutr & Funct Food, Quebec City, PQ G1V 0A6, Canada.
EM valerie.marcil@umontreal.ca
RI Higgins, Johanne/AAF-3672-2019; Sinnett, Daniel/S-4589-2017
OI Sinnett, Daniel/0000-0003-3625-6676; Sultan, Serge/0000-0002-7520-1734;
   Kerba, Marc/0000-0002-2615-3019; Curnier, Daniel/0000-0001-9717-192X
FU Fondation Charles-Bruneau; Fonds de Recherche Quebec en Sante; Fondation
   CHU Sainte-Justine
FX This research was funded by the Fondation Charles-Bruneau, the Fonds de
   Recherche Quebec en Sante and the Fondation CHU Sainte-Justine.
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NR 93
TC 3
Z9 3
U1 2
U2 10
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2227-9067
J9 CHILDREN-BASEL
JI Children-Basel
PD SEP
PY 2022
VL 9
IS 9
AR 1340
DI 10.3390/children9091340
PG 22
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA 4U1EH
UT WOS:000858545500001
PM 36138649
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Vancampfort, D
   Rosenbaum, S
   Schuch, F
   Ward, PB
   Richards, J
   Mugisha, J
   Probst, M
   Stubbs, B
AF Vancampfort, Davy
   Rosenbaum, Simon
   Schuch, Felipe
   Ward, Philip B.
   Richards, Justin
   Mugisha, James
   Probst, Michel
   Stubbs, Brendon
TI Cardiorespiratory Fitness in Severe Mental Illness: A Systematic Review
   and Meta-analysis
SO SPORTS MEDICINE
LA English
DT Review
ID ALL-CAUSE MORTALITY; BODY-MASS INDEX; PHYSICAL-ACTIVITY; METABOLIC
   SYNDROME; AEROBIC EXERCISE; PSYCHOTIC DISORDERS; BIPOLAR DISORDER;
   FOLLOW-UP; SCHIZOPHRENIA; PEOPLE
AB Background Cardiorespiratory fitness (CRF) among people with severe mental illness (SMI) (i.e., schizophrenia, bipolar disorder, and major depressive disorder) is a critical clinical risk factor given its relationship to cardiovascular disease and premature mortality.
   Objectives This study aimed to: (1) investigate the mean CRF in people with SMI versus healthy controls; (2) explore moderators of CRF; and (3) investigate whether CRF improved with exercise interventions and establish if fitness improves more than body mass index following exercise interventions.
   Methods Major electronic databases were searched systematically. A meta-analysis calculating Hedges' g statistic was undertaken.
   Results Across 23 eligible studies, pooled mean CRF was 28.7 mL/kg/min [95 % confidence interval (CI) 27.3 to 30.0 mL/kg/min, p < 0.001, n = 980]. People with SMI had significantly lower CRF compared with controls (n = 310) (Hedges' g = -1.01, 95 % CI -1.18 to -0.85, p < 0.001). There were no differences between diagnostic subgroups. In a multivariate regression, first-episode (beta = 6.6, 95 % CI 0.6-12.6) and inpatient (beta = 5.3, 95 % CI 1.6-9.0) status were significant predictors of higher CRF. Exercise improved CRF (Hedges' g = 0.33, 95 % CI = 0.21-0.45, p = 0.001), but did not reduce body mass index. Higher CRF improvements were observed following interventions at high intensity, with higher frequency (at least three times per week) and supervised by qualified personnel (i.e., physiotherapists and exercise physiologists).
   Conclusion The multidisciplinary treatment of people with SMI should include a focus on improving fitness to reduce all-cause mortality. Qualified healthcare professionals supporting people with SMI in maintaining an active lifestyle should be included as part of multidisciplinary teams in mental health treatment.
C1 [Vancampfort, Davy; Probst, Michel] KU Leuven Univ Leuven, Dept Rehabil Sci, Leuven, Belgium.
   [Vancampfort, Davy] KU Leuven Univ Leuven, Univ Psychiat Ctr, 517 Leuvensesteenweg, B-3070 Kortenberg, Belgium.
   [Rosenbaum, Simon; Ward, Philip B.] Univ New South Wales, Sch Psychiat, Sydney, NSW, Australia.
   [Schuch, Felipe] Hosp Clin Porto Alegre, Porto Alegre, RS, Brazil.
   [Schuch, Felipe] Univ Fed Rio Grande do Sul, Programa Pos Grad Ciencias Med Psiquiatria, Porto Alegre, RS, Brazil.
   [Richards, Justin] Univ Sydney, Sch Publ Hlth, Sydney, NSW, Australia.
   [Richards, Justin] Univ Sydney, Charles Perkins Ctr, Sydney, NSW, Australia.
   [Mugisha, James] Butabika Natl Referral & Mental Hlth Hosp, Kampala, Uganda.
   [Stubbs, Brendon] South London & Maudsley NHS Fdn Trust, Physiotherapy Dept, London, England.
   [Stubbs, Brendon] Kings Coll London, Hlth Serv & Populat Res Dept, Inst Psychiat Psychol & Neurosci, London, England.
C3 KU Leuven; KU Leuven; University of New South Wales Sydney; Hospital de
   Clinicas de Porto Alegre; Universidade Federal do Rio Grande do Sul;
   University of Sydney; University of Sydney; South London & Maudsley NHS
   Trust; University of London; King's College London
RP Vancampfort, D (corresponding author), KU Leuven Univ Leuven, Dept Rehabil Sci, Leuven, Belgium.; Vancampfort, D (corresponding author), KU Leuven Univ Leuven, Univ Psychiat Ctr, 517 Leuvensesteenweg, B-3070 Kortenberg, Belgium.
EM davy.vancampfort@uc-kortenberg.be
RI Vancampfort, Davy/AAD-1987-2019; Probst, Michel/ABE-6137-2020; Stubbs,
   Brendon/X-1904-2018; Schuch, Felipe/AAF-5028-2019; Rosenbaum,
   Simon/Y-3241-2019; Schuch, Felipe/L-4620-2016; Stubbs,
   Brendon/C-5696-2015; Ward, Philip/JCE-6293-2023
OI Schuch, Felipe/0000-0002-5190-4515; Stubbs, Brendon/0000-0001-7387-3791;
   Mugisha, James/0000-0003-2084-8693; Ward, Philip/0000-0002-5779-7722;
   Richards, Justin/0000-0003-4584-8614; Rosenbaum,
   Simon/0000-0002-8984-4941
FU Research Foundation-Flanders (FWOVlaanderen); Collaboration for
   Leadership in Applied Health Research and Care South London
FX Davy Vancampfort has support from the Research Foundation-Flanders
   (FWOVlaanderen). Brendon Stubbs was supported by the Collaboration for
   Leadership in Applied Health Research and Care South London for this
   article. No other sources of funding were used to assist in the
   preparation of this article.
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NR 68
TC 147
Z9 151
U1 1
U2 31
PU ADIS INT LTD
PI NORTHCOTE
PA 5 THE WAREHOUSE WAY, NORTHCOTE 0627, AUCKLAND, NEW ZEALAND
SN 0112-1642
EI 1179-2035
J9 SPORTS MED
JI Sports Med.
PD FEB
PY 2017
VL 47
IS 2
BP 343
EP 352
DI 10.1007/s40279-016-0574-1
PG 10
WC Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Sport Sciences
GA EJ6LY
UT WOS:000393332100010
PM 27299747
DA 2025-06-11
ER

PT J
AU Dalwood, P
   Marshall, S
   Burrows, TL
   McIntosh, A
   Collins, CE
AF Dalwood, Phoebe
   Marshall, Skye
   Burrows, Tracy L.
   McIntosh, Ashleigh
   Collins, Clare E.
TI Diet quality indices and their associations with health-related outcomes
   in children and adolescents: an updated systematic review
SO NUTRITION JOURNAL
LA English
DT Review
DE Diet quality; diet index; pediatrics; Child; Infant; Adolescent;
   Nutrition assessment; Child development; Non-communicable diseases;
   Systematic review
ID EATING INDEX; MEDITERRANEAN DIET; LIFE-STYLE; YOUNG-CHILDREN;
   PRESCHOOL-CHILDREN; FEEDING PRACTICES; FOOD-INTAKE;
   CARDIOVASCULAR-DISEASE; AMERICAN PRESCHOOLERS; EUROPEAN ADOLESCENTS
AB Background: To describe a-priori diet quality indices used in children and adolescents, appraise the validity and reliability of these indices, and synthesise evidence on the relationship between diet quality and physical and mental health, and growth-related outcomes.
   Methods: Five electronic databases were searched until January 2019. An a-priori diet quality index was included if it applied a scoring structure to rate child or adolescent (aged 0-18-years) dietary intakes relative to dietary or nutrient guidelines. Diagnostic accuracy studies and prospective cohort studies reporting health outcomes were appraised using the Academy of Nutrition and Dietetics Quality Criteria Checklist.
   Results: From 15,577 records screened, 128 unique paediatric diet quality indices were identified from 33 countries. Half of the indices' scores rated both food and nutrient intakes (n = 65 indices). Some indices were age specific: infant (< 24-months; n = 8 indices), child (2-12-years; n = 16), adolescent (13-18 years; n = 8), and child/adolescent (n = 14). Thirty-seven indices evaluated for validity and/or reliability. Eleven of the 15 indices which investigated associations with prospective health outcomes reported significant results, such as improved IQ, quality of life, blood pressure, body composition, and prevalence of metabolic syndrome.
   Conclusions: Research utilising diet quality indices in paediatric populations is rapidly expanding internationally. However, few indices have been evaluated for validity, reliability, or association with health outcomes. Further research is needed to determine the validity, reliability, and association with health of frequently utilised diet quality indices to ensure data generated by an index is useful, applicable, and relevant.
   Registration PROSPERO number: CRD42018107630.
C1 [Dalwood, Phoebe; Marshall, Skye; McIntosh, Ashleigh] Bond Univ, Nutr & Dietet Res Grp, Fac Hlth Sci & Med, Robina, Qld 4226, Australia.
   [Marshall, Skye] Nutr Res Australia, Sydney, NSW, Australia.
   [Burrows, Tracy L.; Collins, Clare E.] Univ Newcastle, Fac Hlth & Med, Sch Hlth Sci, Callaghan, NSW 2308, Australia.
   [Burrows, Tracy L.; Collins, Clare E.] Univ Newcastle, Prior Res Ctr Phys Act & Nutr, Callaghan, NSW 2308, Australia.
C3 Bond University; University of Newcastle; University of Newcastle
RP Marshall, S (corresponding author), Bond Univ, Nutr & Dietet Res Grp, Fac Hlth Sci & Med, Robina, Qld 4226, Australia.; Marshall, S (corresponding author), Nutr Res Australia, Sydney, NSW, Australia.
EM skye_marshall@bond.edu.au
RI COLLINS, CLARE/AAO-9933-2020; Burrows, Tracy/G-7802-2013; Marshall,
   Skye/D-2435-2016
OI Burrows, Tracy/0000-0002-1431-7864; Marshall, Skye/0000-0001-8953-5068;
   McIntosh, Ashleigh/0000-0003-2648-0324
FU Australian National Health and Medical Research Council (NHMRC) of
   Australia; University of Newcastle, Faculty of Health and Medicine,
   Gladys M Brawn Senior Research Fellowship; NHMRC investigator grant;
   Commonwealth of Australia Innovations Connections Grant
FX This study received no specific funding. CC is supported by an
   Australian National Health and Medical Research Council (NHMRC) of
   Australia Senior Research Fellowship and a University of Newcastle,
   Faculty of Health and Medicine, Gladys M Brawn Senior Research
   Fellowship. TB is supported by a NHMRC investigator grant. SM is
   partially supported by a Commonwealth of Australia Innovations
   Connections Grant.
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NR 274
TC 89
Z9 96
U1 1
U2 37
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1475-2891
J9 NUTR J
JI Nutr. J.
PD OCT 24
PY 2020
VL 19
IS 1
AR 118
DI 10.1186/s12937-020-00632-x
PG 43
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nutrition & Dietetics
GA OH1JC
UT WOS:000582326900001
PM 33099309
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Bond, DJ
   Kunz, M
   Torres, IJ
   Lam, RW
   Yatham, LN
AF Bond, David J.
   Kunz, Mauricio
   Torres, Ivan J.
   Lam, Raymond W.
   Yatham, Lakshmi N.
TI The association of weight gain with mood symptoms and functional
   outcomes following a first manic episode: prospective 12-month data from
   the Systematic Treatment Optimization Program for Early Mania (STOP-EM)
SO BIPOLAR DISORDERS
LA English
DT Article
DE bipolar disorder; obesity; overweight; psychosocial functioning;
   recurrence; weight gain
ID BIPOLAR-I-DISORDER; BODY-MASS INDEX; QUALITY-OF-LIFE; MULTIDIMENSIONAL
   SCALE; METABOLIC SYNDROME; DIABETES-MELLITUS; MIXED EPISODE;
   RATING-SCALE; OBESITY; PREVALENCE
AB Objectives:
   Up to 75% of patients with bipolar I disorder (BD-I) are overweight or obese. Obesity is associated with an increased liability for mood episodes in patients with established BD-I, but data from early in the illness are lacking. Obesity in the general population is also consistently associated with functional impairment, but the relationship between weight gain and functional outcomes in BD-I has received little attention.
   Methods:
   We measured rates of clinically significant weight gain (CSWG), defined as gaining >= 7% of baseline weight, over 12 months in 46 patients with BD-I who recently recovered from their first manic episode. We compared patients with and without CSWG for (i) the amount of time spent with mood symptoms, assessed using standard clinical rating scales and National Institute of Mental Health Life Charts, and (ii) functioning at 12 months, measured using the Multidimensional Scale of Independent Functioning (MSIF).
   Results:
   A total of 41% of patients (n = 19) experienced CSWG by 12 months. We did not detect an association between CSWG and the number of days with mood symptoms. Patients with CSWG had significantly poorer 12-month global functioning than those without CSWG [MSIF score = 2.26 (SD = 1.24) versus 1.74 (0.98); p = 0.011]. Functional impairment was independent of recent or current mood symptoms, which were entered as covariates in our analyses.
   Conclusions:
   Weight gain may be an overlooked, but potentially modifiable, cause of functional impairment in BD-I. Clinicians should consider the possibility of weight gain when making the earliest treatment decisions in BD-I.
C1 [Bond, David J.; Kunz, Mauricio; Torres, Ivan J.; Lam, Raymond W.; Yatham, Lakshmi N.] Univ British Columbia, Dept Psychiat, Mood Disorders Ctr, Vancouver, BC V6T 2A1, Canada.
C3 University of British Columbia
RP Yatham, LN (corresponding author), Univ British Columbia, Dept Psychiat, UBC Hosp, 2255 Wesbrook Mall,Room 2C7, Vancouver, BC V6T 2A1, Canada.
EM yatham@exchange.ubc.ca
RI Kunz, Mauricio/J-3136-2012; Yatham, Lakshmi N/HCH-4139-2022; Lam,
   Raymond W./D-2529-2013
OI Torres, Ivan/0000-0001-5107-3339; Yatham, Lakshmi N/0000-0002-7405-0954;
   Kunz, Mauricio/0000-0003-3074-1910; Lam, Raymond W./0000-0001-7142-4669;
   Bond, David/0000-0002-8713-7311
FU Canadian Institutes of Health Research Funding Source: Medline
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NR 55
TC 30
Z9 30
U1 0
U2 2
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1398-5647
J9 BIPOLAR DISORD
JI Bipolar Disord.
PD SEP
PY 2010
VL 12
IS 6
BP 616
EP 626
DI 10.1111/j.1399-5618.2010.00855.x
PG 11
WC Clinical Neurology; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA 655DE
UT WOS:000282222300004
PM 20868460
DA 2025-06-11
ER

PT J
AU Saha, S
   Chant, D
   McGrath, J
AF Saha, Sukanta
   Chant, David
   McGrath, John
TI A systematic review of mortality in schizophrenia - Is the differential
   mortality gap worsening over time?
SO ARCHIVES OF GENERAL PSYCHIATRY
LA English
DT Review
ID NEW-GENERATION ANTIPSYCHOTICS; INDUCED WEIGHT-GAIN; QUALITY-OF-LIFE;
   EXCESS MORTALITY; GLOBAL BURDEN; PSYCHIATRIC-PATIENTS; FOLLOW-UP;
   METABOLIC SYNDROME; STOCKHOLM COUNTY; PHYSICAL HEALTH
AB Context: Despite improvements in mental health services in recent decades, it is unclear whether the risk of mortality in schizophrenia has changed over time.
   Objective: To explore the distribution of standardized mortality ratios ( SMRs) for people with schizophrenia.
   Data Sources: Broad search terms were used in MEDLINE, PsychINFO, Web of Science, and Google Scholar to identify all studies that investigated mortality in schizophrenia, published between January 1, 1980, and January 31, 2006. References were also identified from review articles, reference lists, and communication with authors.
   Study Selection: Population- based studies that reported primary data on deaths in people with schizophrenia.
   Data Extraction: Operationalized criteria were used to extract key study features and mortality data.
   Data Synthesis: We examined the distribution of SMRs and pooled selected estimates using random- effects meta- analysis. We identified 37 articles drawn from 25 different nations. The median SMR for all persons for all- cause mortality was 2.58 ( 10%- 90% quantile, 1.185.76), with a corresponding random- effects pooled SMR of 2.50 ( 95% confidence interval, 2.18- 2.43). No sex difference was detected. Suicide was associated with the highest SMR ( 12.86); however, most of the major causes- ofdeath categories were found to be elevated in people with schizophrenia. The SMRs for all- cause mortality have increased during recent decades ( P=. 03).
   Conclusions: With respect to mortality, a substantial gap exists between the health of people with schizophrenia and the general community. This differential mortality gap has worsened in recent decades. In light of the potential for second- generation antipsychotic medications to further adversely influence mortality rates in the decades to come, optimizing the general health of people with schizophrenia warrants urgent attention.
C1 Queensland Ctr Mental Hlth Res, Pk Ctr Mental Hlth, Wacol Q4076, Australia.
   Univ Queensland, Dept Psychiat, St Lucia, Qld, Australia.
C3 Queensland Centre for Mental Health Research; University of Queensland
RP Saha, S (corresponding author), Queensland Ctr Mental Hlth Res, Pk Ctr Mental Hlth, Wacol Q4076, Australia.
EM john_mcgrath@qcmhr.uq.edu.au
RI Saha, Sukanta/K-3774-2012; McGrath, John/G-5493-2010
OI McGrath, John/0000-0002-4792-6068
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NR 100
TC 1557
Z9 1753
U1 0
U2 152
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 0003-990X
EI 1538-3636
J9 ARCH GEN PSYCHIAT
JI Arch. Gen. Psychiatry
PD OCT
PY 2007
VL 64
IS 10
BP 1123
EP 1131
DI 10.1001/archpsyc.64.10.1123
PG 9
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 215YI
UT WOS:000249844500003
PM 17909124
DA 2025-06-11
ER

PT J
AU Chung, GKK
   Yu, RHY
   Woo, J
   Lai, FTT
   Chung, RY
   Yeoh, EK
   Ho, SC
AF Chung, Gary K. K.
   Yu, Ruby H. Y.
   Woo, Jean
   Lai, Francisco T. T.
   Chung, Roger Y.
   Yeoh, Eng-Kiong
   Ho, Suzanne C.
TI Accelerated progression of waist-to-hip ratio but not body mass index
   associated with lower socioeconomic position: a cohort study of nonobese
   early postmenopausal Chinese women
SO MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY
LA English
DT Article
DE Body mass index; Chinese; Cohort studies; Postmenopausal; Socioeconomic
   position; Waist-to-hip ratio; Women
ID SOCIAL INEQUALITIES; METABOLIC SYNDROME; ABDOMINAL OBESITY; HONG-KONG;
   HEALTH; PREVALENCE; ADIPOSITY; MENOPAUSE; MIDLIFE; PERIOD
AB Objective: Menopausal changes are linked to increase in body fat mass and central fat distribution; nonetheless, the impact of socioeconomic position on such changes has rarely been examined. This cohort study assessed the temporal associations of socioeconomic position with changes in body mass index (BMI) and waist-to-hip ratio (WHR) among early postmenopausal women. Methods: Between 2002 and 2004, 518 Hong Kong Chinese women aged 50 to 64 and within 10 years since menopause were recruited and followed up at 3 and 5 years. Weight, height, and waist and hip circumferences were measured by trained interviewers at baseline and follow-up interviews. Socioeconomic positions including educational attainment, economic activity status and household income level, and other baseline demographic characteristics, lifestyle behaviors, and mental health status were collected based on a structured questionnaire. In total, 287 and 267 women with no general and abdominal obesity, respectively, at baseline were included in multiple regression analyses. Results: Mean intrapersonal increases in BMI and WHR between baseline and 5-year interview were 0.46 kg/m(2)and 2.80%, respectively. Women with no secondary education were 75% more likely to have a greater than-mean WHR increase than their more educated counterparts (P = 0.039). Also, having no secondary education (P = 0.041) and being a homemaker (P = 0.034) had accelerated surge in WHR. Nonetheless, baseline socioeconomic positions were not significantly associated with BMI changes. Conclusions: Socioeconomic patterning was observed for the progression of WHR among nonobese Chinese women soon after menopause. Early postmenopausal stage may be a critical window for prevention of abdominal obesity among women with a lower educational attainment.
C1 [Chung, Gary K. K.; Lai, Francisco T. T.; Chung, Roger Y.; Yeoh, Eng-Kiong; Ho, Suzanne C.] Chinese Univ Hong Kong, Fac Med, Jockey Club Sch Publ Hlth & Primary Care, Sha Tin, Hong Kong, Peoples R China.
   [Yu, Ruby H. Y.; Woo, Jean] Chinese Univ Hong Kong, Fac Med, Dept Med & Therapeut, Sha Tin, Hong Kong, Peoples R China.
C3 Chinese University of Hong Kong; Chinese University of Hong Kong
RP Ho, SC (corresponding author), Chinese Univ Hong Kong, Fac Med, Jockey Club Sch Publ Hlth & Primary Care, Div Epidemiol,Sha Tin, Hong Kong, Peoples R China.
EM suzanneho@cuhk.edu.hk
RI Yu, Ruby/N-5006-2015; Chung, Roger/B-7288-2016; Lai,
   Francisco/F-3842-2019; Chung, Gary Ka-Ki/ABA-1266-2021; Woo,
   Jean/K-2625-2014
OI Lai, Francisco/0000-0002-9121-1959; Chung, Gary
   Ka-Ki/0000-0002-8652-212X; Woo, Jean/0000-0001-7593-3081
FU Research Grants Council of Hong Kong [CUHK465807/07]
FX This work was supported by a grant from the Research Grants Council of
   Hong Kong (CUHK465807/07).
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NR 43
TC 6
Z9 7
U1 0
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1072-3714
EI 1530-0374
J9 MENOPAUSE
JI Menopause-J. N. Am. Menopause Soc.
PD MAY
PY 2020
VL 27
IS 5
BP 550
EP 558
DI 10.1097/GME.0000000000001503
PG 9
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Obstetrics & Gynecology
GA NC6YU
UT WOS:000561363700010
PM 32068683
DA 2025-06-11
ER

PT J
AU Ross, E
   Barnett, R
   Tudhope, R
   Vasudev, K
AF Ross, Elyse
   Barnett, Rebecca
   Tudhope, Rebecca
   Vasudev, Kamini
TI Can We Improve Physical Health Monitoring for Patients Taking
   Antipsychotics on a Mental Health Inpatient Unit?
SO JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
LA English
DT Article
DE antipsychotic; physical health monitoring; metabolic side effects;
   quality improvement; inpatient psychiatry
ID METABOLIC RISK; FOLLOW-UP; SCHIZOPHRENIA; INTERVENTION; METAANALYSIS;
   ILLNESS; PEOPLE; MEDICATION; DISORDERS; BARRIERS
AB Background Patients with severe mental illness are at risk of medical complications, including cardiovascular disease, metabolic syndrome, and diabetes. Given this vulnerability, combined with metabolic risks of antipsychotics, physical health monitoring is critical. Inpatient admission is an opportunity to screen for medical comorbidities. Our objective was to improve the rates of physical health monitoring on an inpatient psychiatry unit through implementation of an electronic standardized order set.
   Methods Using a clinical audit tool, we completed a baseline retrospective audit (96 eligible charts) of patients aged 18 to 100 years, discharged between January and March 2012, prescribed an antipsychotic for 3 or more days. We then developed and implemented a standard electronic admission order set and provided training to inpatient clinical staff. We completed a second chart audit of patients discharged between January and March 2016 (190 eligible charts) to measure improvement in physical health monitoring and intervention rates for abnormal results.
   Results In the 2012 audit, thyroid-stimulating hormone (TSH), blood pressure, blood glucose, fasting lipids, electrocardiogram (ECG), and height/weight were measured in 71%, 92%, 31%, 36%, 51%, and 75% of patients, respectively. In the 2016 audit, TSH, blood pressure, blood glucose, fasting lipids, ECG, and height/weight were measured in 86%, 96%, 96%, 64%, 87%, and 71% of patients, respectively. There were statistically significant improvements (P < 0.05) in monitoring rates for blood glucose, lipids, ECG, and TSH. Intervention rates for abnormal blood glucose and/or lipids (feedback to family doctor and/or patient, consultation to hospitalist, endocrinology, and/or dietician) did not change between 2012 and 2016.
   Conclusions Electronic standardized order set can be used as a tool to improve screening for physical health comorbidity in patients with severe mental illness receiving antipsychotic medications.
C1 [Ross, Elyse; Barnett, Rebecca; Vasudev, Kamini] Western Univ, London Hlth Sci Ctr, Dept Psychiat, London, ON, Canada.
   [Tudhope, Rebecca] Strathroy Middlesex Gen Hosp, Dept Psychiat, Strathroy, ON, Canada.
C3 Western University (University of Western Ontario); London Health
   Sciences Centre
RP Ross, E (corresponding author), Victoria Hosp, London Hlth Sci Ctr, Dept Psychiat, 800 Commissioners Rd E, London, ON N6A 5W9, Canada.
EM elyse.ross@lhsc.on.ca
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NR 56
TC 6
Z9 7
U1 0
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0271-0749
EI 1533-712X
J9 J CLIN PSYCHOPHARM
JI J. Clin. Psychopharmacol.
PD OCT
PY 2018
VL 38
IS 5
BP 447
EP 453
DI 10.1097/JCP.0000000000000931
PG 7
WC Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Pharmacology & Pharmacy; Psychiatry
GA GT1OR
UT WOS:000444241500007
PM 30113352
DA 2025-06-11
ER

PT J
AU Strassnig, M
   Kotov, R
   Cornaccio, D
   Fochtmann, L
   Harvey, PD
   Bromet, EJ
AF Strassnig, Martin
   Kotov, Roman
   Cornaccio, Danielle
   Fochtmann, Laura
   Harvey, Philip D.
   Bromet, Evelyn J.
TI Twenty-year progression of body mass index in a county-wide cohort of
   people with schizophrenia and bipolar disorder identified at their first
   episode of psychosis
SO BIPOLAR DISORDERS
LA English
DT Article
DE body mass index; epidemiology; first episode; obesity; psychosis; weight
   gain
ID SERIOUS MENTAL-ILLNESS; ALL-CAUSE MORTALITY; METABOLIC SYNDROME;
   CARDIOVASCULAR-DISEASE; WEIGHT-GAIN; MEDICAL CONDITIONS; LIFE
   EXPECTANCY; UNITED-STATES; FOLLOW-UP; OBESITY
AB Objective: There is an increased prevalence of obesity in schizophrenia and bipolar disorder, leading to a disproportionate risk of adverse health conditions. Prospective, long-term weight gain data, however, are scarce.
   Methods: We analyzed data from the Suffolk County Mental Health Project cohort of consecutive first admissions with psychosis recruited from September 1989 to December 1995 and subsequently followed for 20 years, focusing on people with schizophrenia (n=146) and bipolar disorder (n=87). The time course of weight gain was examined using a 2 (group) x5 (time) mixed-model repeated measures ANOVA, and body mass index (BMI) scores at the first (6 months) and second (2 years) assessments were compared to examine whether early overweight predicted later obesity.
   Results: There was a statistically significant effect of time (F(1,210)=68.06, P<. 001) and diagnosis (F(1,210)=29.18, P<. 001) on BMI, but not the interaction of timexdiagnosis (F(1,210)=0.88, P=.48). Most participants had normal BMIs at the first two assessments. Early overweight was a predictor of eventual obesity for both groups. At the 20-year follow-ups, approximately 50% of the bipolar and 62% of the schizophrenia sample were obese, with a greater prevalence of obesity in schizophrenia at each assessment (all P<. 02), except for years 4 (P=.12) and 20 (P=.27).
   Conclusions: Nearly two-thirds of the participants with schizophrenia and over half of those with bipolar disorder were obese 20 years after first hospitalization for psychosis, considerably higher than the rate for adults in New York State (27%). Early intervention may be required to prevent long-term consequences of obesity-related morbidity and mortality.
C1 [Strassnig, Martin] Florida Atlantic Univ, Dept Integrated Med Sci, Charles Schmidt Coll Med, Boca Raton, FL 33431 USA.
   [Kotov, Roman; Fochtmann, Laura; Bromet, Evelyn J.] SUNY Stony Brook, Dept Psychiat, Stony Brook, NY 11794 USA.
   [Cornaccio, Danielle] Florida Int Univ, Sch Integrated Sci & Humanity, Miami, FL 33199 USA.
   [Harvey, Philip D.] Univ Miami, Miller Sch Med, Dept Psychiat, Miami, FL 33136 USA.
C3 State University System of Florida; Florida Atlantic University; State
   University of New York (SUNY) System; Stony Brook University; State
   University System of Florida; Florida International University;
   University of Miami
RP Strassnig, M (corresponding author), Florida Atlantic Univ, Dept Integrated Med Sci, Charles Schmidt Coll Med, Boca Raton, FL 33431 USA.
EM mstrassnig@health.fau.edu
RI Kotov, Roman/KZV-1103-2024; Harvey, Philip/D-2455-2012
OI Harvey, Philip/0000-0002-9501-9366; Fochtmann, Laura/0000-0001-5080-921X
FU National Institutes of Health [MH44801, MH094398]; Eli Lilly
   Corporation; Stanley Medical Research Institute; Stony Brook
   University's Clinical Research Scholar Award
FX National Institutes of Health, Grant/Award Number: MH44801 and MH094398;
   Eli Lilly Corporation; The Stanley Medical Research Institute; Stony
   Brook University's Clinical Research Scholar Award
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NR 49
TC 49
Z9 49
U1 0
U2 12
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1398-5647
EI 1399-5618
J9 BIPOLAR DISORD
JI Bipolar Disord.
PD AUG
PY 2017
VL 19
IS 5
BP 336
EP 343
DI 10.1111/bdi.12505
PG 8
WC Clinical Neurology; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA FE4VM
UT WOS:000408211400003
PM 28574189
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Bake, S
   Gardner, R
   Tingling, JD
   Miranda, RC
   Sohrabji, F
AF Bake, Shameena
   Gardner, Rachel
   Tingling, Joseph D.
   Miranda, Rajesh C.
   Sohrabji, Farida
TI Fetal Alcohol Exposure Alters Blood Flow and Neurological Responses to
   Transient Cerebral Ischemia in Adult Mice
SO ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
LA English
DT Article
DE Blood Flow; Cerebral Ischemia; Poststroke Recovery; Prenatal Alcohol
ID PRENATAL ETHANOL EXPOSURE; PITUITARY-ADRENAL AXIS; SPECTRUM DISORDERS;
   METABOLIC SYNDROME; INDUCED INFLAMMATION; INSULIN-RESISTANCE; MATERNAL
   NUTRITION; NEPHRON NUMBER; STROKE; CHILDREN
AB Background: Prenatal alcohol exposure (PAE) can result in physical and neurocognitive deficits that are collectively termed "fetal alcohol spectrum disorders" (FASD). Although FASD is associated with lifelong intellectual disability, the mechanisms mediating the emergence of secondary mental health and physical disabilities are poorly understood. Based on our previous data showing that maternal ethanol (EtOH) exposure in mice resulted in an immediate reduction in cranially directed fetal blood flow, we hypothesized that such exposure would also result in persistent alterations in cranially directed blood flow in the prenatally alcohol-exposed (PAE) adult. We also hypothesized that PAE adults exposed to an acute cerebrovascular insult would exhibit more brain damage and neurobehavioral impairment compared to non-PAE adult controls.
   Methods: Pregnant C57BL/6 mice were exposed to EtOH, 3 g/kg, or water by intragastric gavage. Blood flow in carotid, renal, and femoral arteries was assessed by ultrasound imaging in PAE and control adults at 3, 6, and 12 months of age. To mimic ischemic stroke in young adult populations, 3-month-old PAE and control animals were subject to transient middle cerebral artery occlusion (MCAo) and subsequently assessed for behavioral recovery, stroke infarct volume, and brain cytokine profiles.
   Results: PAE resulted in a significant age-related decrease in blood acceleration in adult mice, specifically in the carotid artery. A unilateral transient MCAo resulted in equivalent cortico-striatal damage in both PAE and control adults. However, PAE adult mice exhibited significantly decreased poststroke behavioral recovery compared to controls.
   Conclusions: Our data collectively show that PAE adult mice exhibit a persistent, long-term loss of cranially directed blood flow, and decreased capacity to compensate for brain trauma due to acuteonset adult diseases like ischemic stroke.
C1 [Bake, Shameena; Gardner, Rachel; Tingling, Joseph D.; Miranda, Rajesh C.; Sohrabji, Farida] Texas A&M Univ, Hlth Sci Ctr, Coll Med, Womens Hlth Neurosci Program,Dept Neurosci & Expt, Bryan, TX USA.
C3 Texas A&M University System; Texas A&M University College Station; Texas
   A&M Health Science Center
RP Bake, S (corresponding author), Texas A&M Univ, Hlth Sci Ctr, Dept Neurosci & Expt Therapeut, 4110 MREB,8447 St Hwy 47, Bryan, TX USA.
EM sbake@medicine.tamhsc.edu
OI Sohrabji, Farida/0000-0002-6960-3411; Miranda,
   Rajesh/0000-0002-8359-892X
FU Texas A&M George Chiou Pilot Grant Award;  [R01AG042189]; 
   [R01NS074895];  [R01AA013440];  [R01AA024659];  [R01HD086765]
FX Authors would like to thank Gipshu Dave, Tiffany Heard, and Jeremy
   Rawlings for their assistance at different stages of this study. This
   study was supported by R01AG042189 and R01NS074895 (FS), R01AA013440,
   R01AA024659, and R01HD086765 (RCM), and the Texas A&M George Chiou Pilot
   Grant Award (SB). The authors have declared that no competing conflicts
   of interest exist.
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NR 72
TC 24
Z9 27
U1 0
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0145-6008
EI 1530-0277
J9 ALCOHOL CLIN EXP RES
JI Alcoholism (NY)
PD JAN
PY 2017
VL 41
IS 1
BP 117
EP 127
DI 10.1111/acer.13277
PG 11
WC Substance Abuse
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Substance Abuse
GA EK4IQ
UT WOS:000393890700013
PM 27987329
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Douzenis, A
   Seretis, D
   Nika, S
   Nikolaidou, P
   Papadopoulou, A
   Rizos, EN
   Christodoulou, C
   Tsopelas, C
   Mitchell, D
   Lykouras, L
AF Douzenis, Athanassios
   Seretis, Dionysios
   Nika, Stella
   Nikolaidou, Paraskevi
   Papadopoulou, Athanassia
   Rizos, Emmanouil N.
   Christodoulou, Christos
   Tsopelas, Christos
   Mitchell, Dominic
   Lykouras, Lefteris
TI Factors affecting hospital stay in psychiatric patients: the role of
   active comorbidity
SO BMC HEALTH SERVICES RESEARCH
LA English
DT Article
DE Bipolar; Schizophrenia; Referral; Hospital stay; Physical comorbidity
ID LENGTH-OF-STAY; MEDICAL COMORBIDITY; RATING-SCALE; METABOLIC SYNDROME;
   GLOBAL ASSESSMENT; AUTOIMMUNE-THYROIDITIS; BIPOLAR DISORDER; PHYSICAL
   ILLNESS; RISK-FACTORS; HEALTH
AB Background: Research on length of stay (LOS) of psychiatric inpatients is an under-investigated issue. In this naturalistic study factors which affect LOS of two groups of patients were investigated, focusing on the impact on LOS of medical comorbidity severe enough to require referral.
   Methods: Active medical comorbidity was quantified using referral as the criterion. The study sample consisted of 200 inpatients with the diagnosis of schizophrenia and 228 inpatients suffering from bipolar disorder (type I or II). Jonckheere and Mann-Whitney tests were used to estimate the influence of referrals on LOS, and regression analyses isolated variables associated with LOS separately for each group.
   Results: Half of the patients needed one or more referrals for a non-psychiatric problem. The most common medical condition of patients with bipolar disorder was arterial hypertension. Inpatients with schizophrenia suffered mostly from an endocrine/metabolic disease - 12% of referrals were for Hashimoto's thyroiditis. A positive linear trend was found between LOS and number of referrals; the effect was greater for schizophrenia patients. The effect of referrals on LOS was verified by regression in both groups. Overall, referred patients showed greater improvement in GAF compared to controls.
   Conclusions: To our knowledge this was the first study to investigate physical comorbidity in psychiatric inpatients using the criterion of referral to medical subspecialties. Comorbidity severe enough to warrant referral is a significant determinant of hospital stay. This insight may prove useful in health care planning. The results show lack of effective community care in the case of schizophrenia and negative symptoms may be the cause of this. Our findings call for more attention to be paid to the general medical needs of inpatients with severe mental health and concurrent severe medical comorbidity.
C1 [Douzenis, Athanassios; Nika, Stella; Nikolaidou, Paraskevi; Papadopoulou, Athanassia; Rizos, Emmanouil N.; Christodoulou, Christos; Lykouras, Lefteris] Univ Athens, Sch Med, Dept Psychiat 2, Attikon Gen Hosp, Athens 12462, Greece.
   [Seretis, Dionysios] Univ Bath, Dept Psychol, Bath BA2 7AY, Avon, England.
   [Tsopelas, Christos] Psychiat Hosp Attica, Athens 12462, Greece.
   [Mitchell, Dominic] Univ Bath, Dept Comp Sci, Bath BA2 7AY, Avon, England.
C3 University Hospital Attikon; Athens Medical School; National &
   Kapodistrian University of Athens; University of Bath; University of
   Bath
RP Douzenis, A (corresponding author), Univ Athens, Sch Med, Dept Psychiat 2, Attikon Gen Hosp, 1 Rimini St, Athens 12462, Greece.
EM thandouz@med.uoa.gr
RI Douzenis, Athanasios/AGG-3433-2022; Papadopoulou, Anna/K-5492-2014
OI Seretis, Dionysis/0000-0002-1116-4305; , Douzenis/0000-0002-5321-7276
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NR 48
TC 21
Z9 24
U1 0
U2 1
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1472-6963
J9 BMC HEALTH SERV RES
JI BMC Health Serv. Res.
PD JUN 19
PY 2012
VL 12
AR 166
DI 10.1186/1472-6963-12-166
PG 9
WC Health Care Sciences & Services
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services
GA 022BY
UT WOS:000309931300001
PM 22713232
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Liao, CH
   Chang, CS
   Wei, WC
   Chang, SN
   Liao, CC
   Lane, HY
   Sung, FC
AF Liao, Chun-Hui
   Chang, Chen-Shu
   Wei, Wan-Ching
   Chang, Shih-Ni
   Liao, Chien-Chang
   Lane, Hsien-Yuan
   Sung, Fung-Chang
TI Schizophrenia patients at higher risk of diabetes, hypertension and
   hyperlipidemia: A population-based study
SO SCHIZOPHRENIA RESEARCH
LA English
DT Article
DE Antipsychotics; Retrospective cohort study; Metabolic abnormality;
   Schizophrenia
ID METABOLIC SYNDROME; 2ND-GENERATION ANTIPSYCHOTICS;
   CARDIOVASCULAR-DISEASE; MENTAL-HEALTH; PREVALENCE; MORTALITY; OBESITY;
   COHORT; METAANALYSIS; ASSOCIATION
AB Objective: This study investigates risks of developing diabetes mellitus (DM), hypertension, and hyperlipidemia in treating schizophrenia with first- and second-generation antipsychotics (FGA and SGA, respectively).
   Methods: We established two study sets, each consisting of patients with schizophrenia and without schizophrenia, from the insurance claims from 1997 to 2000. Study set I had 1631 patients taking FGA and 6524 non-schizophrenia controls; the other had 1224 patients taking SGA and 4896 controls. Controls were selected frequency matched with sex, age and the index year. All subjects were free of the studied metabolic disorders at the baseline. We measured incidences of these disorders developed by the end of 2008 in each cohort and their respective hazard ratios (HRs) for these disorders.
   Results: Schizophrenic patients taking FGA were older than those taking SGA. In the Cox models, significance adjusted HRs associated with SGA were 1.82 (95% confidence interval (Cl) 1.30-2.55) for DM and 1.41 (95% Cl 1.09-1.83) for hyperlipidemia. For those on the FGA, the risk was only significant in developing DM (HR 1.32, 95% Cl 1.01-1.75). The age-specific antipsychotics-associated risks for metabolic disorders were higher in young patients than in older patients particularly for hypertension; the HRs in 10-19 years of age were 4.52 (95% Cl 1.76-11.6) associated with FGA and 3.92 (95% Cl 1.83-8.39) associated with SGA.
   Conclusions: Patients with schizophrenia on SGA have higher risk of developing metabolic disorders than those on FGA. It is likely that older patients have already gone through the age of developing these side-effects and were free of them at the baseline. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Liao, Chun-Hui; Lane, Hsien-Yuan] China Med Univ & Hosp, Dept Psychiat, Taichung 404, Taiwan.
   [Liao, Chun-Hui; Wei, Wan-Ching; Chang, Shih-Ni; Liao, Chien-Chang; Sung, Fung-Chang] China Med Univ & Hosp, Dept Publ Hlth, Taichung 404, Taiwan.
   [Chang, Chen-Shu] Changhua Christian Hosp, Dept Neurol, Changhua 500, Taiwan.
   [Chang, Shih-Ni; Liao, Chien-Chang; Sung, Fung-Chang] China Med Univ & Hosp, Management Off Hlth Data, Taichung 404, Taiwan.
C3 China Medical University Taiwan; China Medical University Hospital -
   Taiwan; China Medical University Taiwan; China Medical University
   Hospital - Taiwan; Changhua Christian Hospital; China Medical University
   Taiwan; China Medical University Hospital - Taiwan
RP Sung, FC (corresponding author), China Med Univ, Coll Publ Hlth, 91 Hsueh Shih Rd, Taichung 404, Taiwan.
EM fcsung@mail.cmu.edu.tw
RI Liao, ChunHou/B-8194-2012; Chang, Chun-Hung/AAT-1641-2021; Huang,
   HuiChun/O-9201-2015
FU National Science Council, Executive Yuan, Taiwan, Republic of China [NSC
   97-2625-M-039-003]; China Medical University Hospital [1MS1, DMR-98-067,
   DMR-98-091]; Taiwan Department of Health Clinical Trial and Research
   Center for Excellence [DOH99-TD-B-111-004]; Cancer Research Center of
   Excellence [DOH99-TD-C-111-005]; National Health Research Institute
   (NHRI) of Taiwan
FX This study was supported partly by the National Science Council,
   Executive Yuan, Taiwan, Republic of China (NSC 97-2625-M-039-003), China
   Medical University Hospital (1MS1, DMR-98-067 and DMR-98-091) and Taiwan
   Department of Health Clinical Trial and Research Center for Excellence
   (DOH99-TD-B-111-004) and Cancer Research Center of Excellence
   (DOH99-TD-C-111-005).The database was provided by the National Health
   Research Institute (NHRI) of Taiwan. The interpretation and conclusions
   contained in this article do not represent those of the NHRI.
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NR 39
TC 61
Z9 63
U1 0
U2 10
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0920-9964
EI 1573-2509
J9 SCHIZOPHR RES
JI Schizophr. Res.
PD MAR
PY 2011
VL 126
IS 1-3
BP 110
EP 116
DI 10.1016/j.schres.2010.12.007
PG 7
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 743NS
UT WOS:000289025700016
PM 21216567
DA 2025-06-11
ER

PT J
AU Gil, TE
   Gil, JL
AF Gil, Tomas Escobar
   Gil, Juanita Laverde
TI Artificially Sweetened Beverages Beyond the Metabolic Risks: A
   Systematic Review of the Literature
SO CUREUS JOURNAL OF MEDICAL SCIENCE
LA English
DT Review
DE psychiatry; nutrition; endocrinology; artificial sweetener; diet soda
ID LOW-CALORIE SWEETENERS; DIET SODA INTAKE; CONSUMPTION; SUGAR; HEALTH;
   ASSOCIATION; WEIGHT; ADULTS; MEN
AB We carried out a review of the available literature on the effects that artificially sweetened beverages (ASBs) such as diet soda (DS) have on health, particularly those not related to incident diabetes mellitus, obesity, and metabolic syndrome. A search of scientific articles was carried out using 11 different databases: PubMed, Cochrane, LILACS, MEDLINE Ovid, JAMA Network, IBECS, Cumed, Scopus, SciELO, MEDLINE-EBSCO, and Taylor & Francis Online. Articles published in the last 10 years were considered, considering cross-sectional studies, retrospective or prospective cohort studies, case-control studies, and randomized controlled clinical trials. Only articles in Spanish or English were considered using the MeSH (Medical Subject Heading) and DeCS (Descriptores en Ciencias de la Salud) terms, including "Diet soda," "Health," "Artificial sweetener," "Gaseosa sin azucar," "Refresco sin azucar," and "Salud." Additionally, Boolean operators "AND" and "Y" were used. A total of 1,323 articles were obtained in the initial search, of which 21 main ones were selected for review, which included the topic of DS consumption and explored the health consequences that it poses on different organs. The question of whether ASBs such as DS are a preferred substitute is becoming more and more important in terms of public policy due to mounting evidence of the potential negative health effects of their excessive consumption. This systematic review, the first of its kind to our knowledge, sheds light on how excessive DS consumption can affect multiple organ systems, and associations have been made to mental health burden, delays in child neurodevelopment, cardiac remodeling, worsening retinopathy in diabetics, incidental end -stage renal disease, non-Hodgkin's lymphoma and multiple myeloma in men, rheumatoid arthritis in women, hip fractures, dental erosion, increases in breath alcohol concentration when used in alcoholic beverages, and accelerated cell aging. Further studies should delve further to understand the pathophysiologic mechanisms of these associations.
C1 [Gil, Tomas Escobar] Univ CES, Med, COL, Medellin, Colombia.
   [Gil, Juanita Laverde] Univ CES, Med, COL, Medellin, Colombia.
C3 Universidad CES; Universidad CES
RP Gil, TE (corresponding author), Univ CES, Med, COL, Medellin, Colombia.
EM tescobarg@gmail.com
OI Escobar Gil, Tomas/0000-0001-6761-1170
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NR 40
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SC General & Internal Medicine
GA 8J2VJ
UT WOS:000922278700035
PM 36741610
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Ranjan, P
   Vikram, NK
   Choranur, A
   Pradeep, Y
   Ahuja, M
   Meeta
   Puri, M
   Malhotra, A
   Kumari, A
   Chopra, S
   Batra, A
   Balsalkar, G
   Goswami, D
   Guleria, K
   Sarkar, S
   Kachhawa, G
   Verma, A
   Kumari, MK
   Madan, J
   Dabral, A
   Kamath, S
   Rathore, AM
   Kumar, R
   Venkataraman, S
   Kaloiya, G
   Bhatla, N
   Kumari, SS
   Baitha, U
   Prakash, A
   Tiwaskar, M
   Tewary, K
   Misra, A
   Guleria, R
AF Ranjan, Piyush
   Vikram, Naval K.
   Choranur, Ambuja
   Pradeep, Yashodhara
   Ahuja, Maninder
   Meeta
   Puri, Manju
   Malhotra, Anita
   Kumari, Archana
   Chopra, Sakshi
   Batra, Achla
   Balsalkar, Geetha
   Goswami, Deepti
   Guleria, Kiran
   Sarkar, Siddharth
   Kachhawa, Garima
   Verma, Aditi
   Kumari, M. Krishna
   Madan, Jagmeet
   Dabral, Anjali
   Kamath, Sandhya
   Rathore, Asmita Muthal
   Kumar, Raman
   Venkataraman, Srikumar
   Kaloiya, Gaurishankar
   Bhatla, Neerja
   Kumari, S. Shantha
   Baitha, Upendra
   Prakash, Anupam
   Tiwaskar, Mangesh
   Tewary, Kamlesh
   Misra, Anoop
   Guleria, Randeep
TI Executive summary of evidence and consensus-based Clinical Practice
   Guidelines for management of obesity and overweight in midlife women: An
   AIIMS-DST initiative
SO DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS
LA English
DT Article
DE Midlife; Menopausal transition; Diet; Exercise; Behavioural
   modification; Weight
ID WEIGHT-LOSS; POSTMENOPAUSAL WOMEN; AMERICAN-COLLEGE;
   CARDIOVASCULAR-DISEASE; PERCEIVED BARRIERS; METABOLIC SYNDROME;
   PHYSICAL-ACTIVITY; MENOPAUSAL WOMEN; BODY-COMPOSITION; DIET
AB Background and aims: Weight gain is an independent risk factor for decline in cardiometabolic and overall health-related quality of life in midlife women. The AIIMS-DST initiative aims to develop and validate stepwise recommendations specific for weight management in midlife women.
   Methods: The key clinical questions specific to weight management in midlife women were finalised with the help of a multidisciplinary team of experts in the guideline development group (GDG). Phase I included a systematic and/or narrative review to gather evidence, grading of evidence and expert opinion was sought to develop clinical practice recommendations for each clinical question. Phase II focused on validation of clinical practice recommendations using the peer-review, Delphi method and GRADE approach.
   Results: -The guidelines provide clinical practice points to address challenges encountered by midlife women in their attempts to manage obesity via lifestyle modification techniques. The initiation of discussion would help the healthcare provider to identify the weight management needs of the women, educate women on different modalities of weight management, and empower them to incorporate corrective lifestyle behaviours. Before initiating the management, a comprehensive assessment of clinical and lifestylerelated parameters should be completed. A personalised behavioural lifestyle modification program addressing the midlife specific barriers for optimal metabolic, musculoskeletal, and mental health should be planned. A consistent follow-up is required for maintenance of corrective eating and activity habits by addressing midlife specific barriers for sustenance of healthy weight.
   Conclusion: These recommendations will be useful in opportunistic screening and management of obesity in midlife women across healthcare settings. (C) 2022 Diabetes India and Journal of Mid-Life Health. Published by Elsevier Ltd. All rights reserved.
C1 [Ranjan, Piyush; Vikram, Naval K.; Baitha, Upendra] All India Inst Med Sci, Dept Med, New Delhi 110029, India.
   [Choranur, Ambuja] Osmania Med Coll & Hosp, Indian Menopause Soc, Hyderabad, India.
   [Choranur, Ambuja] Osmania Med Coll & Hosp, Dept Obstet & Gynaecol, Hyderabad, India.
   [Pradeep, Yashodhara] Era Med Coll & Univ, Lucknow, Uttar Pradesh, India.
   [Pradeep, Yashodhara] KGMU, Dept Obstet & Gynaecol, RML Inst Med Sci, Lucknow, Uttar Pradesh, India.
   [Pradeep, Yashodhara] FOGSI, Mumbai, Maharashtra, India.
   [Pradeep, Yashodhara] IMS, Mumbai, Maharashtra, India.
   [Ahuja, Maninder] Soc Meaningful Life Management, Haryana, India.
   [Meeta] Indian Menopause Soc, Hyderabad, India.
   [Puri, Manju] LHMC & SSK Hosp, Dept Obstet & Gynaecol, New Delhi, India.
   [Malhotra, Anita] Univ Delhi, Lakshmibai Coll, Dept Home Sci, Food & Nutr, New Delhi, India.
   [Kumari, Archana; Kachhawa, Garima; Bhatla, Neerja] All India Inst Med Sci, Dept Obstet & Gynaecol, New Delhi, India.
   [Chopra, Sakshi; Verma, Aditi] Univ Delhi, Dept Home Sci, New Delhi, India.
   [Batra, Achla] VMMC & Safdarjung Hosp, Assoc Obstetricians & Gynaecologists Delhi AOGD, New Delhi, India.
   [Batra, Achla; Dabral, Anjali] VMMC & Safdarjung Hosp, Dept Obstet & Gynaecol, New Delhi, India.
   [Balsalkar, Geetha] Seth GS Med Coll, Dept Obstet & Gynaecol, Mumbai, Maharashtra, India.
   [Goswami, Deepti; Rathore, Asmita Muthal] Maulana Azad Med Coll, Dept Obstet & Gynaecol, New Delhi, India.
   [Guleria, Kiran] Univ Coll Med Sci, Dept Obstet & Gynaecol, New Delhi, India.
   [Sarkar, Siddharth] All India Inst Med Sci, Dept Psychiat, New Delhi, India.
   [Sarkar, Siddharth] All India Inst Med Sci, NDDTC, New Delhi, India.
   [Kumari, M. Krishna] Apollo Med Coll, Hyderabad, India.
   [Madan, Jagmeet] Indian Dietet Assoc, Kolkata, India.
   [Kamath, Sandhya] Seth GS Med Coll & KEM Hosp, Mumbai, Maharashtra, India.
   [Kamath, Sandhya] LT Municipal Med Coll & Gen Hosp, Mumbai, Maharashtra, India.
   [Kumar, Raman] Acad Family Phys India, New Delhi, India.
   [Venkataraman, Srikumar] All India Inst Med Sci, Dept Phys Med & Rehabil, New Delhi, India.
   [Kaloiya, Gaurishankar] All India Inst Med Sci, Dept Psychiat, Clin Psychol, New Delhi, India.
   [Kumari, S. Shantha] Federat Obstet & Gynaecol Soc India, Chennai, Tamil Nadu, India.
   [Prakash, Anupam] LHMC & SSK Hosp, Dept Med, New Delhi, India.
   [Tiwaskar, Mangesh; Tewary, Kamlesh] Assoc Phys India, Mumbai, Maharashtra, India.
   [Misra, Anoop] Fortis C DOC Ctr Excellence Diabet Metab Dis & En, New Delhi, India.
   [Misra, Anoop] Natl Diabet Obes & Cholesterol Fdn N DOC, New Delhi, India.
   [Misra, Anoop] Diabet Fdn India, New Delhi, India.
   [Guleria, Randeep] All India Inst Med Sci, New Delhi, India.
C3 All India Institute of Medical Sciences (AIIMS) New Delhi; King George's
   Medical University; Lady Hardinge Medical College & Hospital; University
   of Delhi; All India Institute of Medical Sciences (AIIMS) New Delhi;
   University of Delhi; Vardhman Mahavir Medical College & Safdarjung
   Hospital; Vardhman Mahavir Medical College & Safdarjung Hospital; Seth
   Gordhandas Sunderdas Medical College & King Edward Memorial Hospital;
   Maulana Azad Medical College; University of Delhi; University College of
   Medical Sciences; All India Institute of Medical Sciences (AIIMS) New
   Delhi; All India Institute of Medical Sciences (AIIMS) New Delhi;
   National Drug Dependence Treatment Centre (NDDTC); Seth Gordhandas
   Sunderdas Medical College & King Edward Memorial Hospital; All India
   Institute of Medical Sciences (AIIMS) New Delhi; All India Institute of
   Medical Sciences (AIIMS) New Delhi; Lady Hardinge Medical College &
   Hospital; All India Institute of Medical Sciences (AIIMS) New Delhi
RP Ranjan, P; Vikram, NK (corresponding author), All India Inst Med Sci, Dept Med, New Delhi 110029, India.
EM drpiyushdost@gmail.com; navalvikram@gmail.com
RI Malhotra, Anita/AAJ-8926-2020; Venkataraman, Srikumar/JQV-8304-2023;
   Tiwaskar, Mangesh/AAE-6002-2020
OI Malhotra, Anita/0000-0001-5177-4514; Venkataraman,
   Srikumar/0000-0002-5367-6288; Tiwaskar, Mangesh/0000-0003-4024-0095;
   RANJAN, PIYUSH/0000-0002-1754-1167
FU SEED division, Department of Science and Technology, Government of India
   [SEED/WS/2019/526 (G)]
FX The study was financially supported by the SEED division, Department of
   Science and Technology, Government of India (Grant
   number-SEED/WS/2019/526 (G)).
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NR 102
TC 8
Z9 9
U1 0
U2 2
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 1871-4021
EI 1878-0334
J9 DIAB MET SYND CLIN R
JI DIABET. METAB. SYNDR. CLIN. RES. REV.
PD MAR
PY 2022
VL 16
IS 3
AR 102426
DI 10.1016/j.dsx.2022.102426
EA MAR 2022
PG 12
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA 2Q6KM
UT WOS:000820529400003
PM 35248973
DA 2025-06-11
ER

PT J
AU Kamioka, H
   Nakamura, Y
   Okada, S
   Kitayuguchi, J
   Kamada, M
   Honda, T
   Matsui, Y
   Mutoh, Y
AF Kamioka, Hiroharu
   Nakamura, Yosikazu
   Okada, Shinpei
   Kitayuguchi, Jun
   Kamada, Masamitsu
   Honda, Takuya
   Matsui, Yuzuru
   Mutoh, Yoshiteru
TI Effectiveness of Comprehensive Health Education Combining Lifestyle
   Education and Hot Spa Bathing for Male White-Collar Employees: A
   Randomized Controlled Trial with 1-Year Follow-Up
SO JOURNAL OF EPIDEMIOLOGY
LA English
DT Article
DE male; white-collar-employees; randomized controlled trial; lifestyle
   education; hot spa; exercise
ID QUALITY-OF-LIFE; PHYSICAL-ACTIVITY; WATER IMMERSION; OBESITY; ARTHRITIS;
   THERAPY; RESORT; WORK
AB Background: Physical activity is known to prevent obesity and metabolic syndrome in middle-aged and elderly people; however, the effectiveness of a comprehensive health education program for male white-collar employees is uncertain.
   Methods: Forty-three men volunteered to participate in this study and were randomly assigned into 2 groups. The intervention group participated in a 2-hour program comprising comprehensive health education and hot spa bathing, offered once every 2 weeks, in addition to individualized programs once a week, for 24 weeks. The control group received only general health guidance. We compared their lifestyle characteristics and physical and mental health criteria at baseline, immediately after the intervention, and I year after the end of the intervention.
   Results: Rates of adherence to individualized programs were 60.0 +/- 27.2% and 30.5 +/- 29.6% at the end of the intervention and at I year after the end of the intervention, respectively. Significant (P < 0.05) interaction of criteria was observed for cluster of differentiation 4+ (CD4+) cells and the ratio of cluster of differentiation 4+ to 8+ (CD4/8) cells, which were used to represent the participants' immunological function. We divided the intervention group into 2 Subgroups on the basis of their attendance. Among the resulting 3 groups, significant interaction of criteria was observed for CD4+ and CD4/8 cells. In addition, the high attendance group had the highest CD4+ Count and CD4/8 ratio.
   Conclusions: Participants who attended classes and/or performed the Supplementary individualized programs tended to maintain their immunological function and to experience a decrease in body fat percentage. However, few effects were noted in participants with poor adherence, even in the intervention group.
C1 [Kamioka, Hiroharu] Tokyo Univ Agr, Fac Reg Environm Sci, Setagaya Ku, Tokyo 1568502, Japan.
   [Nakamura, Yosikazu] Jichi Med Univ, Dept Publ Hlth, Shimotsuke, Tochigi, Japan.
   [Okada, Shinpei] Phys Educ & Med Res Fdn, Nagano, Japan.
   [Kitayuguchi, Jun; Kamada, Masamitsu] Phys Educ & Med Res Ctr Unnan, Unnan, Shimane, Japan.
   [Honda, Takuya; Mutoh, Yoshiteru] Univ Tokyo, Dept Phys & Hlth Educ, Grad Sch Educ, Tokyo, Japan.
   [Matsui, Yuzuru] Unnan Hosp, Dept Orthoped, Unnan, Shimane, Japan.
C3 Tokyo University of Agriculture; Jichi Medical University; University of
   Tokyo
RP Kamioka, H (corresponding author), Tokyo Univ Agr, Fac Reg Environm Sci, Setagaya Ku, Sakuragaoka 1-1-1, Tokyo 1568502, Japan.
EM h1kamiok@nodai.ac.jp
RI ; Kamada, Masamitsu/H-4411-2011
OI Okada, Shimpei/0000-0002-5093-2506; Kamada,
   Masamitsu/0000-0003-1703-076X
FU Japanese Ministry of Health, Labour and Welfare in Japan
FX This study was supported by Health and Labor Sciences Research Grants
   (Research on Cancer Prevention and Health Services) from the Japanese
   Ministry of Health, Labour and Welfare in Japan in 2006, 2007, and 2008.
CR Bender T, 2005, RHEUMATOL INT, V25, P220, DOI 10.1007/s00296-004-0487-4
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NR 37
TC 17
Z9 17
U1 0
U2 4
PU JAPAN EPIDEMIOLOGICAL ASSOC
PI FUKUOKA
PA FUKUOKA INST HEALTH & ENVIRONMENTAL SCIENCES, MUKAIZANO 39, DAZAIFU,
   FUKUOKA, 818-0135, JAPAN
SN 0917-5040
J9 J EPIDEMIOL
JI J. Epidemiol.
PD SEP
PY 2009
VL 19
IS 5
BP 219
EP 230
DI 10.2188/jea.JE20081020
PG 12
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA 493YM
UT WOS:000269775700002
PM 19687610
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Appuhamy, KK
   Podmore, D
   Mitchell, A
   Ahmed, HU
   Ashworth, M
   Boehnke, JR
   Chongtham, V
   Chowdhury, AH
   Garcia, OP
   Holt, RIG
   Huque, R
   Muliyala, KP
   Onstenk, EK
   Rajan, S
   Shiers, D
   Siddiqi, N
   Manjunatha, S
   Zavala, GA
AF Appuhamy, Koralagamage Kavindu
   Podmore, Danielle
   Mitchell, Alex
   Ahmed, Helal Uddin
   Ashworth, Mark
   Boehnke, Jan R.
   Chongtham, Virtu
   Chowdhury, Asiful Haidar
   Garcia, Olga P.
   Holt, Richard I. G.
   Huque, Rumana
   Muliyala, Krishna Prasad
   Onstenk, Eline Klein
   Rajan, Sukanya
   Shiers, David
   Siddiqi, Najma
   Manjunatha, S.
   Zavala, Gerardo A.
TI Risk factors associated with overweight and obesity in people with
   severe mental illness in South Asia: cross-sectional study in
   Bangladesh, India, and Pakistan
SO JOURNAL OF NUTRITIONAL SCIENCE
LA English
DT Article
DE Obesity; Overweight; Severe mental illness; South Asia
ID CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; BIPOLAR DISORDER; STATEMENT;
   SCHIZOPHRENIA; DISPARITIES; PREVALENCE; COUNTRIES; BURDEN; HEALTH
AB Obesity is one of the major contributors to the excess mortality seen in people with severe mental illness (SMI) and in low- and middle-income countries people with SMI may be at an even greater risk. In this study, we aimed to determine the prevalence of obesity and overweight in people with SMI and investigate the association of obesity and overweight with sociodemographic variables, other physical comorbidities, and health-risk behaviours. This was a multi-country cross-sectional survey study where data were collected from 3989 adults with SMI from three specialist mental health institutions in Bangladesh, India, and Pakistan. The prevalence of overweight and obesity was estimated using Asian BMI thresholds. Multinomial regression models were then used to explore associations between overweight and obesity with various potential determinants. There was a high prevalence of overweight (17 center dot 3 %) and obesity (46 center dot 2 %). The relative risk of having obesity (compared to normal weight) was double in women (RRR = 2 center dot 04) compared with men. Participants who met the WHO recommendations for fruit and vegetable intake had 2 center dot 53 (95 % CI: 1 center dot 65-3 center dot 88) times greater risk of having obesity compared to those not meeting them. Also, the relative risk of having obesity in people with hypertension is 69 % higher than in people without hypertension (RRR = 1 center dot 69). In conclusion, obesity is highly prevalent in SMI and associated with chronic disease. The complex relationship between diet and risk of obesity was also highlighted. People with SMI and obesity could benefit from screening for non-communicable diseases, better nutritional education, and context-appropriate lifestyle interventions.
C1 [Appuhamy, Koralagamage Kavindu; Podmore, Danielle; Mitchell, Alex; Boehnke, Jan R.; Siddiqi, Najma; Zavala, Gerardo A.] Univ York, Dept Biol, York, England.
   [Ahmed, Helal Uddin] Natl Inst Mental Hlth & Hosp, Dhaka, Bangladesh.
   [Ashworth, Mark] Kings Coll London, Sch Lifecourse & Populat Sci, London, England.
   [Boehnke, Jan R.] Univ Dundee, Sch Hlth Sci, Dundee, Scotland.
   [Chongtham, Virtu] Govt Med Coll & Hosp, Dept Psychiat, Chandigarh, India.
   [Chowdhury, Asiful Haidar; Huque, Rumana] ARK Fdn, Dhaka, Bangladesh.
   [Garcia, Olga P.] Univ Autonoma Queretaro, Fac Ciencias Nat, Santiago De Queretaro, Mexico.
   [Holt, Richard I. G.] Univ Southampton, Fac Med, Human Dev & Hlth, Southampton, England.
   [Holt, Richard I. G.] Univ Hosp Southampton, Southampton Natl Inst Hlth Res, Biomed Res Ctr, Southampton, England.
   [Muliyala, Krishna Prasad; Rajan, Sukanya; Manjunatha, S.] Natl Inst Mental Hlth & Neurosci, Bangalore, India.
   [Onstenk, Eline Klein] Vrije Univ Amsterdam, Amsterdam, Netherlands.
   [Shiers, David] Greater Manchester Mental Hlth NHS Trust, Psychosis Res Unit, Manchester, England.
   [Shiers, David] Univ Manchester, Div Psychol & Mental Hlth, Manchester, England.
   [Shiers, David] Keele Univ, Sch Med, Keele, England.
   [Siddiqi, Najma] Hull York Med Sch, York, England.
   [Siddiqi, Najma] Bradford Dist Care NHS Fdn Trust, Bradford, England.
C3 University of York - UK; University of London; King's College London;
   University of Dundee; Universidad Autonoma de Queretaro; University of
   Southampton; National Institute of Mental Health & Neurosciences -
   India; Vrije Universiteit Amsterdam; University of Manchester; Keele
   University; University of York - UK; University of Hull
RP Appuhamy, KK (corresponding author), Univ York, Dept Biol, York, England.
EM kka505@york.ac.uk
RI Siddiqi, Najma/X-6298-2019; Rajan, Sukanya/LGZ-8227-2024; Boehnke,
   Jan/H-3468-2019; Zavala, Gerardo/J-4525-2019; García, Olga/GPT-0624-2022
OI Shivarudraiah, Dr. Manjunatha/0000-0002-0055-165X; Podmore,
   Danielle/0000-0001-9365-7850; Garcia, Olga P/0000-0003-4040-8345;
   Appuhamy, Koralagamage/0000-0002-0195-6608; Boehnke, Jan
   R./0000-0003-0249-1870; shiers, david/0000-0003-2531-5837
FU National Institute for Health and Care Research; National Institute for
   Health Research (NIHR) from UK Government [GHRG 17/63/130]; COVID
   [MR/V033433/1] Funding Source: UKRI
FX The authors would like to acknowledge Abu Musa Robin, Anjuman Jum Tithi,
   Tanvir Arafat, Lipon Saha, Tasmia Rahman, Dr. Khaleda Islam, Dr. Mamun,
   Dr. Bappi, from the team in Bangladesh, Archith Krishna, Sathish Kumar,
   Neeta P.S, Venkatalakshmi, Bhuvneshwari L, Manjunatha S, Sobin George,
   Krishna Jayanthi from the team in India and Rubab Ayesha, Nida Afsheen,
   Najma Hayat, Zaheen Amin, and Aniqa Maryam from the team in Pakistan for
   conducting all the interviews and physical measurements, providing
   technical and managerial support. The authors also would like to thank
   all the participants who consented and provided their time to complete
   the interview.N. S. and J. B. conceived the study. K. A., D. P., A. M.,
   and G. Z. designed the study, K. A., D. P., A. M., V. C., A. C.,R. H.,
   K. P. M., and S. R. were involved in data curation. D. P., A. M., V. C.,
   A. C., R. H., K. P. M., S. R., and G. Z. were all involved in data
   analysis. K. A., D. P.,A. M., and G. Z. contributed to the original
   draft and all authors revised and approved the final manuscript.This
   research was funded by the National Institute for Health Research (NIHR)
   (Grant: GHRG 17/63/130:) using UK aid from the UK Government to support
   global health research. The views expressed in this publication are
   those of the author(s) and not necessarily those of the NIHR or the UK
   Department of Health and Social Care.D. S. is an expert advisor to the
   NICE Centre for Guidelines; the views expressed are the authors' and not
   those of NICE.This study was conducted according to the guidelines laid
   down in the Declaration of Helsinki and all procedures involving
   research study participants were approved by the ethics committees of
   the Department of Health Sciences, University of York, UK (HSRGC-3/17);
   the Centre for Injury Prevention and Research, Bangladesh (CIPRB/ERC/2OI
   8/003); the Institute Ethics Committee, National Institute of Mental
   Health and Neurosciences, India(BEH.SC.DIV 20/19); the Health Ministry
   Screening Committee, India (HMSC12/18); and the National Bioethics
   Committee, Pakistan (4-18/NBC-413/19). Written informed consent was
   obtained from all patients.
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NR 49
TC 0
Z9 0
U1 0
U2 1
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 2048-6790
J9 J NUTR SCI
JI J. Nutr. Sci.
PD NOV 21
PY 2023
VL 12
AR e116
DI 10.1017/jns.2023.100
PG 14
WC Nutrition & Dietetics
WE Emerging Sources Citation Index (ESCI)
SC Nutrition & Dietetics
GA Y8MD3
UT WOS:001107737200001
PM 38033510
OA Green Accepted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Charlton, R
   Gravenor, MB
   Rees, A
   Knox, G
   Hill, R
   Rahman, MA
   Jones, K
   Christian, D
   Baker, JS
   Stratton, G
   Brophy, S
AF Charlton, Richard
   Gravenor, Michael B.
   Rees, Anwen
   Knox, Gareth
   Hill, Rebecca
   Rahman, Muhammad A.
   Jones, Kerina
   Christian, Danielle
   Baker, Julien S.
   Stratton, Gareth
   Brophy, Sinead
TI Factors associated with low fitness in adolescents - A mixed methods
   study
SO BMC PUBLIC HEALTH
LA English
DT Article
DE Eduation and health; Risk factors; Diabetes; Heart disease; Physical
   activity
ID SHUTTLE RUN TEST; PHYSICAL-ACTIVITY; METABOLIC SYNDROME;
   ACADEMIC-ACHIEVEMENT; SECULAR TRENDS; RISK-FACTORS; CHILDREN;
   PERFORMANCE; OBESITY; SCHOOL
AB Background: Fitness and physical activity are important for cardiovascular and mental health but activity and fitness levels are declining especially in adolescents and among girls. This study examines clustering of factors associated with low fitness in adolescents in order to best target public health interventions for young people.
   Methods: 1147 children were assessed for fitness, had blood samples, anthropometric measures and all data were linked with routine electronic data to examine educational achievement, deprivation and health service usage. Factors associated with fitness were examined using logistic regression, conditional trees and data mining cluster analysis. Focus groups were conducted with children in a deprived school to examine barriers and facilitators to activity for children in a deprived community.
   Results: Unfit adolescents are more likely to be deprived, female, have obesity in the family and not achieve in education. There were 3 main clusters for risk of future heart disease/diabetes (high cholesterol/insulin); children at low risk (not obese, fit, achieving in education), children 'visibly at risk' (overweight, unfit, many hospital/GP visits) and 'invisibly at risk' (unfit but not overweight, failing in academic achievement). Qualitative findings show barriers to physical activity include cost, poor access to activity, lack of core physical literacy skills and limited family support.
   Conclusions: Low fitness in the non-obese child can reveal a hidden group who have high risk factors for heart disease and diabetes but may not be identified as they are normal weight. In deprived communities low fitness is associated with non-achievement in education but in non-deprived communities low fitness is associated with female gender. Interventions need to target deprived families and schools in deprived areas with community wide campaigns.
C1 [Charlton, Richard; Gravenor, Michael B.; Hill, Rebecca; Rahman, Muhammad A.; Jones, Kerina; Brophy, Sinead] Swansea Univ, Coll Med, Swansea SA2 8PP, W Glam, Wales.
   [Rees, Anwen] Univ Wales Coll Cardiff, Sch Sport, Inst Cardiff, Cardiff CF23 6XD, S Glam, Wales.
   [Knox, Gareth] Univ W England, Hartpury Coll, Appl Sport Sci, Gloucester, England.
   [Christian, Danielle] Swansea Univ, Coll Hlth & Human Sci, Swansea SA2 9PP, W Glam, Wales.
   [Baker, Julien S.] Univ W Scotland, Sch Sci, Inst Clin Exercise & Hlth Sci, Hamilton, Lanark, Scotland.
   [Stratton, Gareth] Swansea Univ, Coll Engn, Swansea SA2 8PP, W Glam, Wales.
C3 Swansea University; Cardiff University; University of West England;
   Swansea University; University of West Scotland; Swansea University
RP Brophy, S (corresponding author), Swansea Univ, Coll Med, Swansea SA2 8PP, W Glam, Wales.
EM s.brophy@swansea.ac.uk
RI stratton, Gareth/Z-5471-2019; Rahman, Muhammad/GLR-8606-2022; Stratton,
   Gareth/Q-2746-2017
OI Brophy, Sinead/0000-0001-7417-2858; Stratton,
   Gareth/0000-0001-5618-0803; Christian, Danielle/0000-0003-1117-6127;
   Jones, Kerina/0000-0001-8164-3718
FU Economic and Social Research Council; Welsh Assembly Government
   [H7-3-016]; MRC [MR/K023233/1, MR/K006525/1] Funding Source: UKRI
FX This study was funded by a studentship from the Economic and Social
   Research Council and from grant funding from the Welsh Assembly
   Government (H7-3-016). The funder had no role in study design,
   interpretation of data, writing of the report, or decision to submit. We
   would like to thank the schools and pupils who gave their time to help
   with this research.
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NR 38
TC 38
Z9 44
U1 1
U2 38
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2458
J9 BMC PUBLIC HEALTH
JI BMC Public Health
PD JUL 29
PY 2014
VL 14
AR 764
DI 10.1186/1471-2458-14-764
PG 10
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA AN7RA
UT WOS:000340796800001
PM 25074589
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Driesen, K
   Jansen, NWH
   Kant, I
   Mohren, DCL
   van Amelsvoort, LGPM
AF Driesen, Karolien
   Jansen, Nicole W. H.
   Kant, IJmert
   Mohren, Danielle C. L.
   van Amelsvoort, Ludovic G. P. M.
TI DEPRESSED MOOD IN THE WORKING POPULATION: ASSOCIATIONS WITH WORK
   SCHEDULES AND WORKING HOURS
SO CHRONOBIOLOGY INTERNATIONAL
LA English
DT Article; Proceedings Paper
CT 19th International Symposium on Shiftwork and Working Time
CY AUG 02-06, 2009
CL Venice, ITALY
DE Depressed mood; Epidemiology; Mental health; Shiftwork; Working time
   arrangements
ID TERM SICKNESS ABSENCE; SHIFT-WORK; METABOLIC SYNDROME;
   SLEEP-DEPRIVATION; MENTAL-DISORDERS; HEALTH; PREVALENCE; FATIGUE;
   ANXIETY; PREDICTOR
AB The impact of working time arrangements (WTA) on health has been studied extensively. Still, little is known about the interrelation between work schedules, working hours, and depressed mood. For work schedules, the underlying assumptions regarding depressed mood refer to a disturbance of social and biological rhythms, whereas for working hours, the assumptions relate to workload and work capacity. Conversely, depressed mood may urge an employee to adjust his/her work schedule and/or number of working hours/week (h/wk). The aim of this study was to assess the association between work schedule and working hours with depressed mood. Using baseline data from the Maastricht Cohort Study, depressed mood in day work was compared with depressed mood in different shiftwork schedules (n = 8843). Within day work, several categories of working h/wk were studied in association with depressed mood (n = 7217). The association between depressed mood and several aspects of overtime was assessed separately. Depressed mood was measured with a dichotomous item: "Did you feel down every day over the last two weeks?" Separate logistic regression analyses were conducted for men and women, with adjustments for potential confounders. The odds ratio (OR) for depressed mood was greater for men involved in shiftwork than for men only involved in day work (three-shift OR = 2.05 [95% confidence interval, CI 1.52-2.77]; five-shift OR = 1.34 [95% CI 1.00-1.80]; irregular-shift OR = 1.79 [95% CI 1.27-2.53]). In female employees, five-shift work was associated with a higher prevalence of depressed mood (OR = 5.96 [95% CI 2.83-12.56]). Regarding the number of working h/wk, men working <26 h/wk had a higher prevalence of depressed mood than men working 36-40 h/wk (OR = 2.73 [95% CI 1.35-5.52]). After conducting trend analyses, a significant decreasing trend was found in men, whereas an increasing trend was found in women working a high number of hours. Furthermore, a dose-response relationship was present in men regarding the number of overtime h/wk. This study showed that different work schedules and working hours are associated with depressed mood. Shiftwork was related to a higher prevalence of depressed mood than day work. The association was more pronounced for male employees. Regarding the number of working h/wk, male and female employees showed an opposite trend in depressed mood. Because of the possibility of a healthy worker effect and the possibility of a reciprocal relationship between WTA and depressed mood, the reported relation might be underestimated. This study has illustrated that occupational physicians, who deal with depressed mood among workers, should carefully consider the impact of WTA. (Author coorespondence: Karolien.Driesen@epid.unimaas.nl)
C1 [Driesen, Karolien; Jansen, Nicole W. H.; Kant, IJmert; Mohren, Danielle C. L.; van Amelsvoort, Ludovic G. P. M.] Maastricht Univ, Dept Epidemiol, Fac Hlth Med & Life Sci, CAPHRI Sch Publ Hlth & Primary Care, NL-6200 MD Maastricht, Netherlands.
C3 Maastricht University
RP Driesen, K (corresponding author), Maastricht Univ, Dept Epidemiol, Fac Hlth Med & Life Sci, CAPHRI Sch Publ Hlth & Primary Care, POB 616, NL-6200 MD Maastricht, Netherlands.
EM Karolien.Driesen@epid.unimaas.nl
RI van Amelsvoort, Ludovic/A-3689-2008
OI van Amelsvoort, Ludovic/0000-0003-0120-1552
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NR 62
TC 87
Z9 98
U1 1
U2 34
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 0742-0528
EI 1525-6073
J9 CHRONOBIOL INT
JI Chronobiol. Int.
PY 2010
VL 27
IS 5
BP 1062
EP 1079
DI 10.3109/07420528.2010.489877
PG 18
WC Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI); Conference Proceedings Citation Index - Science (CPCI-S)
SC Life Sciences & Biomedicine - Other Topics; Physiology
GA 652SI
UT WOS:000282029800014
PM 20636216
DA 2025-06-11
ER

PT J
AU Zieff, G
   Bancks, MP
   Gabriel, KP
   Gibbs, BB
   Moore, JB
   Reis, JP
   Stone, K
   Stoner, L
AF Zieff, Gabriel
   Bancks, Michael P.
   Gabriel, Kelley Pettee
   Gibbs, Bethany Barone
   Moore, Justin B.
   Reis, Jared P.
   Stone, Keeron
   Stoner, Lee
TI Associations of nonoccupational sedentary behaviors with cardiometabolic
   outcomes: coronary artery risk development in young adults (CARDIA)
SO ANNALS OF BEHAVIORAL MEDICINE
LA English
DT Article
DE sedentary behavior; hypertension; diabetes; cardiometabolic risk;
   observational cohort
ID MEASURED PHYSICAL-ACTIVITY; TYPE-2 DIABETES-MELLITUS;
   CARDIOVASCULAR-DISEASE; BLOOD-PRESSURE; TIME; HEALTH; RELIABILITY;
   VALIDITY; QUESTIONNAIRE; DEPRESSION
AB Background The association between sedentary behavior (SB) and cardiometabolic risk may differ by SB domain and context. Nonoccupational SB is particularly important because it is discretionary and more amenable to change. This study estimated associations of nonoccupational SB contexts with hypertension (HTN) and diabetes mellitus (DM).Methods A total of 3370 middle-aged adults (50.1 +/- 3.6 years; 56% F) from the Coronary Artery Risk Development in Young Adults (CARDIA) study were included. Cross-sectional and 5-year prospective associations between self-report total SB and 6 context-specific SBs (television-TV, computer, transportation, phone, music, and paperwork) with HTN and DM were tested using logistic regression. Fully adjusted models controlled for sociodemographic variables, body mass index, and self-report moderate-vigorous intensity physical activity.Results Prevalences of HTN and DM at baseline were 48% (1618 cases) and 10% (320 cases), respectively. Each hour per day of total-SB was cross-sectionally associated with HTN (OR: 1.03, 95% CI, 1.01-1.05) but not DM, with nonsignificant prospective associations for HTN and DM. Of the context-specific SBs, only TV-SB was significantly associated with HTN or DM. Each hour of TV-SB was cross-sectionally associated with HTN (OR: 1.09, 95% CI, 1.03-1.15) and DM (OR: 1.18, 95% CI, 1.09-1.29), and prospectively with HTN (OR: 1.14, 95% CI, 1.04-1.26) but not DM.Conclusion When comparing total-SB and the 6 context-specific SBs, TV-SB was most robustly associated with HTN. The findings were less clear for DM. Behavior change strategies that target TV-SB reduction may be effective at reducing HTN risk in middle-aged adults.
   The link between sedentary behavior (SB) and health risks may differ by the type (context) of SB. Nonwork-related SB is important because it is discretionary and can more easily be changed. This study looked at associations of nonwork-related SB contexts with high blood pressure (BP) and diabetes in 3370 middle-aged adults from the Coronary Artery Risk Development in Young Adults (CARDIA) study. Cross-sectional and 5-year prospective associations between total SB and 6 context-specific SBs (television-TV, computer, transportation, phone, music, and paperwork) with high BP and diabetes were tested. Our analyses controlled for sociodemographic variables, body mass index, and physical activity.At baseline, 48% of participants had high BP and 10% had diabetes. At baseline, each hour per day of total-SB was associated with high BP. Additionally, each hour of TV-SB was associated with high BP and diabetes. TV-SB also predicted high BP 5 years later. When comparing total-SB and the 6 context-specific SBs, TV-SB was most strongly associated with high BP. The findings were less clear for diabetes. Behavior change strategies that target TV-SB reduction may be effective at reducing high BP risk in middle-aged adults.
C1 [Zieff, Gabriel; Stoner, Lee] Univ North Carolina, Dept Exercise & Sport Sci, Chapel Hill, NC 27514 USA.
   [Zieff, Gabriel] Univ British Columbia, Sch Kinesiol, Vancouver, BC V6T 1Z1, Canada.
   [Bancks, Michael P.; Moore, Justin B.] Wake Forest Univ, Bowman Gray Sch Med, Dept Epidemiol & Prevent, Winston Salem, NC 27101 USA.
   [Gabriel, Kelley Pettee] Univ Alabama Birmingham, Dept Epidemiol, Birmingham, AL 35233 USA.
   [Gibbs, Bethany Barone] West virginia Univ, Sch Publ Hlth, Dept epidemiol & Biostat, Morgantown, WV 26505 USA.
   [Moore, Justin B.] Wake Forest Univ, Bowman Gray Sch Med, Dept Implementat Sci, Div Publ Hlth Sci, Winston Salem, NC 27101 USA.
   [Reis, Jared P.] NHLBI, Epidemiol Branch, Bethesda, MD 20817 USA.
   [Stone, Keeron] Cardiff Metropolitan Univ, Ctr Cardiovasc Hlth & Ageing, Cardiff Sch Sport & Hlth Sci, Cardiff CF5 2YB, Wales.
   [Stone, Keeron] Natl Cardiovasc Res Network, Cardiff, Wales.
   [Stoner, Lee] Univ North Carolina, Gillings Sch Publ Hlth, Dept Epidemiol, Chapel Hill, NC 27599 USA.
   [Stoner, Lee] Univ North Carolina, Ctr Hlth Promot & Dis Prevent, Chapel Hill, NC 27599 USA.
C3 University of North Carolina; University of North Carolina Chapel Hill;
   University of British Columbia; Wake Forest University; Wake Forest
   Baptist Medical Center; University of Alabama System; University of
   Alabama Birmingham; West Virginia University; Wake Forest University;
   Wake Forest Baptist Medical Center; National Institutes of Health (NIH)
   - USA; NIH National Heart Lung & Blood Institute (NHLBI); Cardiff
   Metropolitan University; University of North Carolina; University of
   North Carolina Chapel Hill; University of North Carolina; University of
   North Carolina Chapel Hill
RP Zieff, G (corresponding author), Univ British Columbia, Sch Kinesiol, Vancouver, BC V6T 1Z1, Canada.
EM gabriel.zieff@ubc.ca
RI Stoner, Lee/C-8504-2011; Zieff, Gabriel/NFS-1809-2025; Moore,
   Justin/B-9357-2012
OI Stone, Keeron/0000-0001-6572-7874; Bancks, Michael/0000-0003-3694-6060;
   Moore, Justin/0000-0003-4059-0538
FU National Heart, Lung, and Blood Institute (NHLBI); University of Alabama
   at Birmingham [75N92023D00002, 75N92023D00005]; Northwestern University
   [75N92023D00004]; University of Minnesota [75N92023D00006]; Kaiser
   Foundation Research Institute [75N92023D00003]; Health and Care Research
   Wales
FX The Coronary Artery Risk Development in Young Adults Study (CARDIA) is
   conducted and supported by the National Heart, Lung, and Blood Institute
   (NHLBI) in collaboration with the University of Alabama at Birmingham
   (75N92023D00002 & 75N92023D00005), Northwestern University
   (75N92023D00004), University of Minnesota (75N92023D00006), and Kaiser
   Foundation Research Institute (75N92023D00003). This manuscript has been
   reviewed by CARDIA for scientific content. Dr Keeron Stone is supported
   by the Health and Care Research Wales funded National Cardiovascular
   Research Network, Wales.
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NR 90
TC 0
Z9 0
U1 0
U2 0
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0883-6612
EI 1532-4796
J9 ANN BEHAV MED
JI Ann. Behav. Med.
PD DEC 13
PY 2024
VL 59
IS 1
DI 10.1093/abm/kaae074
EA DEC 2024
PG 13
WC Psychology, Multidisciplinary
WE Social Science Citation Index (SSCI)
SC Psychology
GA T4W3T
UT WOS:001376316100001
PM 39671511
OA hybrid
DA 2025-06-11
ER

PT J
AU Banach, W
   Nitschke, K
   Krajewska, N
   Mongiallo, W
   Matuszak, O
   Muszynski, J
   Skrypnik, D
AF Banach, Weronika
   Nitschke, Karolina
   Krajewska, Natalia
   Mongiallo, Wojciech
   Matuszak, Oskar
   Muszynski, Jozef
   Skrypnik, Damian
TI The Association between Excess Body Mass and Disturbances in Somatic
   Mineral Levels
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE obesity; excess body mass; body mass index; minerals; elements
ID OXIDATIVE STRESS; ZINC SUPPLEMENTATION; OBESE CHILDREN; IRON OVERLOAD;
   OVERWEIGHT; CHROMIUM; MAGNESIUM; METABOLISM; INSULIN; GLUCOSE
AB Background: Obesity and excess body weight are significant epidemiological issues, not only because they are costly to treat, but also because they are among the leading causes of death worldwide. In 2016, an estimated 40% of the global population was overweight, reflecting the importance of the issue. Obesity is linked to metabolism malfunction and concomitantly with altered mineral levels in the body. In this paper, we review alterations in somatic levels of iron, calcium, magnesium, copper, iodine, chromium, selenium, and zinc in relation to excess body mass. Methodology: An electronic literature search was performed using PubMed. Our search covered original English research articles published over the past five years, culminating in 63 papers included for study. Results: The reviewed papers presented correlation between obesity and hypomagnesemia and hypozincemia. They also indicated that patients with excess body mass present increased body copper levels. Studies have similarly indicated that obesity appears to be associated with lower selenium levels in both blood and urine, which may be correlated with the decline and weakening of defenses against oxidative stress. It has been found that decreased level of chromium is connected with metabolic syndrome. Chromium supplementation influences body mass, but the effect of the supplementation depends on the chemical form of the chromium. It is hypothesized that obesity poses a risk of iodine deficiency and iodine absorption may be disrupted by increased fat intake in obese women. A range of studies have suggested that obesity is correlated with iron deficiency. On the other hand, some reports have indicated that excess body mass may coexist with iron excess. The relation between obesity and body iron level requires further investigation. Calcium signaling seems to be disturbed in obesity, due to the increased production of reactive oxygen species and low level of fast troponin isoform responsible for mediating calcium sensitivity of muscle relaxation. Correlation between excess body mass and calcium levels needs further research. Conclusions: Excess body mass is associated with alterations in mineral levels in the body, in particular hypomagnesemia and decreased selenium (Se) and zinc (Zn) levels. Chromium (Cr) deficiency is associated with metabolic syndrome. Obese patients are at risk of iodine deficiency. Excess body mass is associated with elevated levels of copper (Cu). Data on the association between obesity and iron (Fe) levels are contradictory. Obesity coexists with disturbed calcium (Ca) signaling pathways. The association between obesity and body Ca levels has not been investigated in detail.
C1 [Banach, Weronika; Nitschke, Karolina; Krajewska, Natalia; Mongiallo, Wojciech; Matuszak, Oskar; Muszynski, Jozef] Poznan Univ Med Sci, Fac Med, Fredry St 10, PL-61701 Poznan, Poland.
   [Skrypnik, Damian] Poznan Univ Med Sci, Dept Treatment Obes Metab Disorders & Clin Dietet, Szamarzewskiego St 82-84, PL-60569 Poznan, Poland.
C3 Poznan University of Medical Sciences; Poznan University of Medical
   Sciences
RP Skrypnik, D (corresponding author), Poznan Univ Med Sci, Dept Treatment Obes Metab Disorders & Clin Dietet, Szamarzewskiego St 82-84, PL-60569 Poznan, Poland.
EM weronika.wb98@gmail.com; karolinanitschke@wp.pl; krajnat@gmail.com;
   wojmzl@gmail.com; oskar.piotr.matuszak@gmail.com;
   joozef.muszynski@gmail.com; damian.skrypnik@gmail.com
RI Skrypnik, Damian/AAZ-9602-2021
OI Skrypnik, Damian/0000-0001-5643-6899; Muszynski,
   Jozef/0009-0000-7229-4747
FU ProScience Young Scientists grant from Pozna [502-14-21191730-11315,
   4089]
FX This study was funded by a ProScience Young Scientists grant from Poznan
   University of Medical Sciences, no. 502-14-21191730-11315; ID: 4089,
   awarded to Damian Skrypnik. The funding source had no role in the design
   of the study, the collection of the data, the analysis or interpretation
   of the data, the writing of the manuscript, or the decision to publish
   the results.
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NR 62
TC 31
Z9 31
U1 1
U2 12
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD OCT
PY 2020
VL 21
IS 19
AR 7306
DI 10.3390/ijms21197306
PG 14
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA ON5EN
UT WOS:000586724200001
PM 33022938
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Abudigin, WI
   Bajaber, A
   Subash-Babu, P
AF Abudigin, Weaam I.
   Bajaber, Adnan
   Subash-Babu, Pandurangan
TI Impact of various dietary lipids on amelioration of biomarkers linked to
   metabolic syndrome in both healthy and diabetic Wistar rats
SO BMC NUTRITION
LA English
DT Article
DE Dietary lipids; Saturated fats; Oxidative stress; Inflammation;
   Cardiovascular diseases
ID UNSATURATED FATTY-ACIDS; LIPOPROTEIN-LIPASE; GLUCOSE; OBESITY;
   STREPTOZOTOCIN; ABCA1
AB BackgroundThe present study was designed to investigate the influence of different dietary lipids (sheep's fat, olive oil, coconut oil, and corn oil) on specific biomarkers associated with metabolic syndrome in both healthy and diabetic rats.MethodsThe study designed for 45 days, utilized a male diabetic wistar rat (body weight, 180-220 g) model induced by streptozotocin (45 mg/kg bw). The rats were divided into two sections: five non-diabetic and five diabetic groups, each containing six rats. The first group in each section serving as the control, received a standard diet. Both non-diabetic or diabetic groups, were provided with a standard diet enriched with 15% sheep fat, 15% coconut oil, 15% olive oil, and 15% corn oil, respectively for a duration of 45 days.ResultsPost-supplementation, both healthy and diabetic control rats exhibited a higher food intake compared to rats supplemented with lipid diet; notably food intake was higher in diabetic control than healthy control. However, rats fed with coconut oil, olive oil and sheep fat showed weight gain at the end of the experiment, in both healthy and diabetic groups. Coconut oil supplementation significantly (p <= 0.05) increased HDL-C and total cholesterol level in diabetic groups compared to healthy group, it was confirmed by an increased PPAR-alpha and ABCA-1 protein level. Olive oil significantly decreased triglyceride, total cholesterol, and LDL-C levels in diabetic rats when compared to sheep fat or coconut oil. Corn oil significantly decreased fasting glucose, total cholesterol and LDL-C levels compared to all other groups. Corn and olive oil supplemented normal groups, found with significant increase in hepatic glucose-lipid oxidative metabolism associated protein, like FGF-21, MSH, ABCA-1, PPAR-gamma and decreased lipogenesis proteins like, SREBP and PPAR-alpha levels. In contrast, sheep grease and coconut oil increased SREBP and PPAR-alpha expression in both normal and diabetic groups. Most notably, normal and diabetic groups pretreated with sheep grease resulted in increased inflammatory (MCP-1, IL-1 beta, TLR-4, TNF-alpha), and oxidative stress markers (LPO, GSH, GPx, SOD and CAT) linked with metabolic complications.ConclusionThe combination or alternative use of olive oil and corn oil in daily diet may play a significant role in preventing proinflammatory condition associated with insulin resistance and cardiovascular diseases.
C1 [Abudigin, Weaam I.; Bajaber, Adnan; Subash-Babu, Pandurangan] King Saud Univ, Coll Food & Agr Sci, Dept Food Sci & Nutr, POB 22452, Riyadh 11459, Saudi Arabia.
C3 King Saud University
RP Abudigin, WI (corresponding author), King Saud Univ, Coll Food & Agr Sci, Dept Food Sci & Nutr, POB 22452, Riyadh 11459, Saudi Arabia.
EM 435203120@student.ksu.edu.sa
OI Pandurangan, Subash-Babu/0000-0003-3938-071X
FU King Abdul Aziz city for science and technology, Riyadh, Saudi Arabia
   [1-18-04-001-0010]
FX This work was funded through the Researchers Supporting Project [no.
   1-18-04-001-0010], King Abdul Aziz city for science and technology,
   Riyadh, Saudi Arabia.
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NR 53
TC 2
Z9 2
U1 1
U2 2
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 2055-0928
J9 BMC NUTR
JI BMC Nutr.
PD MAY 16
PY 2024
VL 10
IS 1
AR 75
DI 10.1186/s40795-024-00881-7
PG 12
WC Nutrition & Dietetics
WE Emerging Sources Citation Index (ESCI)
SC Nutrition & Dietetics
GA WN1X4
UT WOS:001255473100001
PM 38755663
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Lotti, F
   Corona, G
   Degli Innocenti, S
   Filimberti, E
   Scognamiglio, V
   Vignozzi, L
   Forti, G
   Maggi, M
AF Lotti, F.
   Corona, G.
   Degli Innocenti, S.
   Filimberti, E.
   Scognamiglio, V.
   Vignozzi, L.
   Forti, G.
   Maggi, M.
TI Seminal, ultrasound and psychobiological parameters correlate with
   metabolic syndrome in male members of infertile couples
SO ANDROLOGY
LA English
DT Article
ID PENILE DOPPLER ULTRASOUND; PEAK SYSTOLIC VELOCITY; BODY-MASS INDEX;
   ERECTILE DYSFUNCTION; PREMATURE EJACULATION; FEMALE FERTILITY; FLACCID
   STATE; MEN; OBESITY; HYPOGONADISM
AB Metabolic syndrome (MetS) is a diagnostic category which identifies subjects at high risk for diabetes and cardiovascular diseases, erectile dysfunction (ED) and male hypogonadism. However, MetS impact on male infertility has been poorly studied. We systematically evaluated possible associations between MetS and clinical characteristics in men with couple infertility. Out of 367 consecutive subjects, 351 men without genetic abnormalities were studied. MetS was defined according to the International Diabetes Federation&American Heart Association/National Heart, Lung, and Blood Institute classification. All men underwent physical, hormonal, seminal and scrotal ultrasound evaluation. Erectile and ejaculatory functions were assessed by International Index of Erectile Function-15 erectile function domain (IIEF-15-EFD) and Premature Ejaculation Diagnostic Tool (PEDT), respectively, while psychological symptoms by Middlesex Hospital Questionnaire. Out of 351 patients, 27 (7.7%) fulfilled MetS criteria. Among ultrasound features, in an age-adjusted logistic model, only testis inhomogeneity was significantly associated with increasing MetS factors (HR = 1.36 [1.09-1.70]; p < 0.01). In an age-adjusted model, MetS was associated with a stepwise decline in total testosterone (TT) (B = -1.25 +/- 0.33; p < 0.0001), without a concomitant rise in gonadotropins. At univariate analysis, progressive motility and normal morphology were negatively related to the number of MetS components (both p < 0.0001), but when age and TT were introduced in a multivariate model, only sperm morphology retained a significant association (B = -1.418 +/- 0.42; p = 0.001). The risk of ED (IIEF-15-EFD score <26) increased as a function of the number of MetS factors, even after adjusting for age and TT (HR = 1.45[1.08-1.95]; p < 0.02). No association between PEDT score and MetS was observed. Finally, after adjusting for age and TT, somatization and depressive symptoms were associated with increasing MetS components (B = 0.66 +/- 0.03, p < 0.05; B = 0.69 +/- 0.03, p < 0.02; respectively). In conclusion, in men with couple infertility, MetS is associated with hypogonadism, poor sperm morphology, testis ultrasound inhomogeneity, ED, somatization and depression. Recognizing MetS could help patients to improve not only fertility but also sexual and overall health.
C1 [Lotti, F.; Corona, G.; Degli Innocenti, S.; Filimberti, E.; Scognamiglio, V.; Vignozzi, L.; Forti, G.; Maggi, M.] Univ Florence, Sexual Med & Androl Unit, Dept Clin Physiopathol, I-50139 Florence, Italy.
   [Corona, G.] Maggiore Bellaria Hosp, Endocrinol Unit, Bologna, Italy.
C3 University of Florence; AUSL di Bologna
RP Maggi, M (corresponding author), Univ Florence, Sexual Med & Androl Unit, Dept Clin Physiopathol, Viale Pieraccini 6, I-50139 Florence, Italy.
EM m.maggi@dfc.unifi.it
RI Lotti, Francesco/AAC-3186-2019; Maggi, Mario/AAB-8284-2019; LOTTI,
   Francesco/K-1801-2018
OI LOTTI, Francesco/0000-0001-8343-1807; Vignozzi,
   Linda/0000-0003-0907-0630; MAGGI, Mario/0000-0003-3267-4221
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NR 76
TC 81
Z9 84
U1 0
U2 11
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2047-2919
EI 2047-2927
J9 ANDROLOGY-US
JI Andrology
PD MAR
PY 2013
VL 1
IS 2
BP 229
EP 239
DI 10.1111/j.2047-2927.2012.00031.x
PG 11
WC Andrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 097GW
UT WOS:000315463000007
PM 23315971
DA 2025-06-11
ER

PT J
AU Nikrad, N
   Shakarami, A
   Tousi, AZ
   Farhangi, MA
   Ardekani, AM
   Jafarzadeh, F
AF Nikrad, Negin
   Shakarami, Amir
   Tousi, Ayda Zahiri
   Farhangi, Mahdieh Abbasalizad
   Ardekani, Abnoos Mokhtari
   Jafarzadeh, Faria
TI Dietary Antioxidant Quality Score (DAQS), serum lipids, markers of
   glucose homeostasis, blood pressure and anthropometric features among
   apparently metabolically healthy obese adults in two metropolises of
   Iran (Tabriz and Tehran): a cross-sectional study
SO BMC ENDOCRINE DISORDERS
LA English
DT Article
DE Dietary antioxidant quality score; Cardio-metabolic diseases; Obesity;
   Overweight; Blood pressure; Metabolic profile; Glycemic markers;
   Metabolic syndrome
ID VITAMIN-C SUPPLEMENTATION; PHYSICAL-ACTIVITY; OXIDATIVE STRESS;
   NITRIC-OXIDE; RISK-FACTORS; ASSOCIATION; HYPERTENSION; METAANALYSIS;
   POPULATION; CHILDREN
AB BackgroundOxidative stress (OS) is associated with a variety of non-communicable diseases, including MetS, diabetes mellitus, metabolic syndrome, and cardiovascular disease through increased production of reactive oxygen species (ROS) and impairment of antioxidant defense mechanisms. Antioxidants can protect cells against free radical damage, so it seems important to determine the relationship between the quality of dietary antioxidants intake and chronic diseases. The Dietary Antioxidant Quality Score (DAQS) is obtained by adding the daily intake of known dietary vitamins and minerals, including selenium, zinc, vitamin A, vitamin C, and vitamin E, compared to the recommended daily intake (RDI). Therefore, this study aims to determine the relationship between DAQS, serum lipids, markers of glucose homeostasis, blood pressure and anthropometric features among obese adults.MethodsIn the present cross-sectional study, 338 individuals who were obese (BMI & GE; 30 kg/m(2)) aged 20-50 years were recruited from Tabriz and Tehran, Iran. A validated semi-quantitative Food Frequency Questionnaire (FFQ) with 168 food items was used to quantify dietary consumption; accordingly, DAQS was computed. Blood biomarkers were measured using enzyme-linked immunosorbent assay (ELISA) kits. A standard mercury sphygmomanometer was used to assess blood pressure, and bioelectrical impedance analysis (BIA) was performed to determine body composition. The association between the DAQS tertiles and biochemical variables was investigated using multinomial logistic regression.ResultsParticipants in the highest tertile of DAQS have a lower diastolic blood pressure (DBP) values in all of the adjusted models [odds ratio (OR) = 0.920; confidence interval (CI)= 0.852-0.993, P-value = 0.03] in the analysis of co-variance (ANCOVA) model. Similarly, subjects at the second tertile of DAQS had lower DBP compared with the first tertile in age and sex-adjusted model [OR= 0.937; CI= 0.882-0.997]. There was no statistically significant difference for other metabolic parameters in different DAQS tertiles.ConclusionAccording to our findings, higher DAQS was associated with lower DBP among obese adults with obesity in two major cities of Iran (Tehran and Tabriz). Other studies with interventional design are needed to better elucidate these associations and underlying mechanisms.
C1 [Nikrad, Negin; Farhangi, Mahdieh Abbasalizad] Tabriz Univ Med Sci, Tabriz Hlth Serv Management Res Ctr, Tabriz, Iran.
   [Shakarami, Amir] Lorestan Univ Med Sci, Dept Cardiovasc Med, Cardiol, Khorramabad, Iran.
   [Tousi, Ayda Zahiri] Imam Reza Int Univ, Razavi Hosp, Razavi Canc Res Ctr, Mashhad, Iran.
   [Farhangi, Mahdieh Abbasalizad] Tabriz Univ Med Sci, Fac Nutr, Dept Nutr Commun, Tabriz, Iran.
   [Ardekani, Abnoos Mokhtari] Kerman Univ Med Sci, Inst Basic & Clin Physiol Sci, Endocrinol & Metab Res Ctr, Kerman, Iran.
   [Ardekani, Abnoos Mokhtari] Kerman Univ Med Sci, Physiol Res Ctr, Kerman, Iran.
   [Jafarzadeh, Faria] North Khorasan Univ Med Sci, Sch Med, Dept Internal Med, Endocrinol & Metab, Bojnourd, Iran.
C3 Tabriz University of Medical Science; Lorestan University of Medical
   Sciences; Tabriz University of Medical Science; Kerman University of
   Medical Sciences; Kerman University of Medical Sciences; North Khorasan
   University of Medical Sciences
RP Ardekani, AM (corresponding author), Kerman Univ Med Sci, Inst Basic & Clin Physiol Sci, Endocrinol & Metab Res Ctr, Kerman, Iran.; Ardekani, AM (corresponding author), Kerman Univ Med Sci, Physiol Res Ctr, Kerman, Iran.; Jafarzadeh, F (corresponding author), North Khorasan Univ Med Sci, Sch Med, Dept Internal Med, Endocrinol & Metab, Bojnourd, Iran.
EM ardekaniabnoos@gmail.com; f.jafarzadeh@nkums.ac.ir
RI Shakarami, Amir/KVA-6459-2024; Farhangi, Mahdieh/AAC-6758-2019;
   jafarzadeh, faria/E-1413-2018; Mokhtari, Abnoos/GYV-5829-2022; Nikrad,
   Negin/JZD-3883-2024
OI JAFARZADEH, FARIA/0009-0003-5883-098X
FU Tabriz University of Medical Sciences [IR.TBZMED.REC.1401.647, 72135]
FX <STRONG>& nbsp;</STRONG>The present study was financially supported by a
   grant from Tabriz University of Medical Sciences. (Code:
   IR.TBZMED.REC.1401.647 and grant number:& nbsp;72135).The funders had no
   role in hypothesis generation, recruiting and designing the study.
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NR 70
TC 6
Z9 6
U1 2
U2 7
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1472-6823
J9 BMC ENDOCR DISORD
JI BMC Endocr. Disord.
PD JUL 21
PY 2023
VL 23
IS 1
AR 157
DI 10.1186/s12902-023-01392-5
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA N0WN7
UT WOS:001034322200001
PM 37479979
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Handa, NID
   Murwani, R
   Juniarto, AZ
AF Handa, Nur I. D.
   Murwani, Retno
   Juniarto, Achmad Zulfa
TI Etlingera elatior (Jack) R.M, Sm Containing Diet Normalizes Some
   Metabolic Syndrome Markers due to High-fat High-fructose Diet in Wistar
   Rats
SO CURRENT NUTRITION & FOOD SCIENCE
LA English
DT Article
DE Bunga kecombrang; my plate; piringku; dyslipidemia; obesity;
   phytonutrients; vegetables
ID SERUM-LIPID PROFILE; OXIDATIVE STRESS; OBESE
AB Background: Etlingera elatior (Ee) contains phytochemical compounds that are rich in antioxidants, which may reduce several biochemical markers of metabolic syndrome (MetS).
   Objective: We aimed to study the effect of fresh Etlingera elatior (FEe) and steamed Etlingera elatior (SEe) as a part of rat diet on body weight, serum lipid, and malondialdehyde (MDA) level in Wistar rats with MetS induced by a high-fat, high-fructose diet.
   Methods: Our research was a true experimental randomized control group design with pre- and post-test. A total of 24 male Wistar rats were divided randomly into the following four groups: 1) Control, fed standard rat diet during the whole duration of the study, 2) HFFr-Sd, fed high-fat high-fructose(HFFr) diet for 29 days, followed by 29 days of the standard diet, 3) HFFr-FEe, fed HFFr diet for 29 days, followed by 29 days of a standard diet containing 33.3% FEe, and 4) HFFr-SEe, fed HFFr diet for 29 days, followed by 29 days of a standard diet containing 33.3% SEe. The HFFr diet was given at 15 g/day along with fructose drink (20% pure fructose) at 100 ml/day. The diets in each group after the MetS induction period are referred to as intervention diets. Data at the end of HFFr (pre) and intervention diets (post) were analyzed by paired t-test. The data among groups were analyzed by one-way analysis of variance followed by post hoc test.
   Results: HFFr diet for 29 days induced MetS in Wistar rats fulfilling the criteria of obesity (Lee Index), hypertriglyceridemia, and decreased high-density lipoprotein cholesterol (HDL-C). Also, there was a significant increase in serum total cholesterol, low-density lipoprotein cholesterol (LDL-C), and MDA level (p < 0.05). Feeding a diet containing FEe or SEe can significantly reduce body weight, serum triglyceride, total cholesterol, LDL-C, and MDA, and increase HDL-C levels (p < 0.05). The effect of FEe was more pronounced in ameliorating body weight and lipid profile than SEe.
   Conclusion: Fresh Ee and Steamed Ee can ameliorate obesity, dyslipidemia, and oxidative stress in MetS Wistar rats induced by a high-fat, high-fructose diet. It suggests that dietary Ee accounting for one-third of daily standard diet can assist in normalizing some MetS markers in rats.
C1 [Handa, Nur I. D.; Murwani, Retno] Univ Diponegoro, Fac Med, Dept Nutr, Masters Program Nutr Sci, Semarang 50275, Indonesia.
   [Murwani, Retno] Univ Diponegoro, Fac Anim & Agr Sci, Lab Physiol & Biochem, Semarang 50275, Indonesia.
   [Juniarto, Achmad Zulfa] Univ Diponegoro FMDU, Div Human Genet, Ctr Biomed Res, Fac Med, Semarang 50275, Indonesia.
   [Murwani, Retno] Univ Diponegoro, Nat Prod Lab, Integrated Lab Res & Serv Lab Terpadu, Semarang 50275, Indonesia.
C3 Diponegoro University; Diponegoro University; Diponegoro University
RP Murwani, R (corresponding author), Univ Diponegoro, Fac Med, Dept Nutr, Masters Program Nutr Sci, Semarang 50275, Indonesia.
EM rmurwani.undip@gmail.com
RI Murwani, Retno/AAB-3647-2020; Juniarto, Achmad Zulfa/HZM-2392-2023
OI Juniarto, Achmad Zulfa/0000-0002-5466-7690; Murwani,
   Retno/0000-0002-6237-8354; Hanifah, Nur/0000-0002-1088-2807
FU LPPM (Institute of Research and Community Service) Diponegoro University
FX We thank LPPM (Institute of Research and Community Service) Diponegoro
   University for proof reading funding of this article.
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NR 35
TC 1
Z9 1
U1 0
U2 2
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1573-4013
EI 2212-3881
J9 CURR NUTR FOOD SCI
JI Curr. Nutr. Food Sci.
PY 2021
VL 17
IS 7
BP 727
EP 736
DI 10.2174/1573401316666201208101359
PG 10
WC Nutrition & Dietetics
WE Emerging Sources Citation Index (ESCI)
SC Nutrition & Dietetics
GA UA2QP
UT WOS:000685009000009
OA hybrid
DA 2025-06-11
ER

PT J
AU Berge, RK
   Cacabelos, D
   Señarís, R
   Nordrehaug, JE
   Nygård, O
   Skorve, J
   Bjorndal, B
AF Berge, Rolf K.
   Cacabelos, Daniel
   Senaris, Rosa
   Nordrehaug, Jan Erik
   Nygard, Ottar
   Skorve, Jon
   Bjorndal, Bodil
TI Hepatic steatosis induced in C57BL/6 mice by a non-ss oxidizable fatty
   acid analogue is associated with reduced plasma kynurenine metabolites
   and a modified hepatic NAD<SUP>+</SUP>/NADH ratio
SO LIPIDS IN HEALTH AND DISEASE
LA English
DT Article
DE Non-alcoholic fatty liver; Kynurenine metabolites; Hepatic NAD
   metabolism; Mouse model
ID LIVER-DISEASE; TRYPTOPHAN SUPPLEMENTATION; OXIDATION; LOCALIZATION;
   TRIGLYCERIDE; INFLAMMATION; CATABOLISM; BIOMARKERS; INCREASES; DIET
AB Background Non-alcoholic fatty liver disease is often associated with obesity, insulin resistance, dyslipidemia, and the metabolic syndrome in addition to mitochondrial dysfunction and nicotinamide adenine dinucleotide (NAD(+)) deficiency. The aim of this study was to investigate how inhibition of mitochondrial fatty acid oxidation using the compound tetradecylthiopropionic acid (TTP) would affect hepatic triacylglycerol level and plasma levels of kynurenine (Kyn) metabolites and nicotinamide. Methods 12 C57BL/6 mice were fed a control diet, or an intervention diet supplemented with 0.9% (w/w) tetradecylthiopropionic acid for 14 days. Blood and liver samples were collected, enzyme activities and gene expression were analyzed in liver, in addition to fatty acid composition. Metabolites in the tryptophan/kynurenine pathway and total antioxidant status were measured in plasma. Results Dietary treatment with tetradecylthiopropionic acid for 2 weeks induced fatty liver accompanied by decreased mitochondrial fatty acid oxidation. The liver content of the oxidized form of NAD(+) was increased, as well as the ratio of NAD(+)/NADH, and these changes were associated by increased hepatic mRNA levels of NAD synthetase and nicotinamide mononucleotide adenyltransferase-3. The downstream metabolites of kynurenine were reduced in plasma whereas the plasma nicotinamide content was increased. Some effects on inflammation and oxidative stress was observed in the liver, while the plasma antioxidant capacity was increased. This was accompanied by a reduced plasma ratio of kynurenine/tryptophan. In addition, a significant decrease in the inflammation-related arachidonic fatty acid in liver was observed. Conclusion Fatty liver induced by short-time treatment with tetradecylthiopropionic acid decreased the levels of kynurenine metabolites but increased the plasma levels of NAD(+) and nicotinamide. These changes are most likely not associated with increased inflammation and oxidative stress. Most probably the increase of NAD(+) and nicotinamide are generated through the Preiss Handler pathway and/or salvage pathway and not through the de novo pathway. The take home message is that non-alcoholic fatty liver disease is associated with the metabolic syndrome in addition to mitochondrial dysfunction and nicotinamide adenine dinucleotide (NAD(+)) deficiency. Inducing fatty liver in mice by inhibition of fatty acid oxidation resulted in a concomitant change in kynurenine metabolites increasing the plasma levels of nicotinamides and the hepatic NAD(+)/NADH ratio, probably without affecting the de novo pathway of kynurenines.
C1 [Berge, Rolf K.; Cacabelos, Daniel; Nordrehaug, Jan Erik; Nygard, Ottar; Skorve, Jon; Bjorndal, Bodil] Univ Bergen, Dept Clin Sci, Bergen, Norway.
   [Berge, Rolf K.; Nygard, Ottar] Haukeland Hosp, Dept Heart Dis, Bergen, Norway.
   [Cacabelos, Daniel; Senaris, Rosa] Univ Santiago de Compostela, Dept Physiol, CIMUS, Inst Invest Sanitaria, Santiago De Compostela, Spain.
   [Nordrehaug, Jan Erik] Stavanger Univ Hosp, Dept Heart Dis, Stavanger, Norway.
   [Nygard, Ottar] Univ Bergen, KG Jebsen Ctr Diabet Res, Bergen, Norway.
C3 University of Bergen; University of Bergen; Haukeland University
   Hospital; Universidade de Santiago de Compostela; Stavanger University
   Hospital; University of Bergen
RP Berge, RK (corresponding author), Univ Bergen, Dept Clin Sci, Bergen, Norway.; Berge, RK (corresponding author), Haukeland Hosp, Dept Heart Dis, Bergen, Norway.
EM rolf.berge@uib.no
RI Barral, Daniel/C-3951-2011; Bjorndal, Bodil/H-6143-2017
OI Senaris, Rosa/0000-0002-4536-2609; Bjorndal, Bodil/0000-0001-9718-5117
FU Bergen Research Foundation [18113]; Western Norway Regional Health
   Authority [911945]
FX The Bergen Research Foundation (grant number 18113) and The Western
   Norway Regional Health Authority (grant number 911945) funded this
   study. The founding sources had no involvement in the study design; in
   the collection, analysis and interpretation of data; in the writing of
   the report; and in the decision to submit the article for publication.
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NR 36
TC 9
Z9 9
U1 0
U2 13
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1476-511X
J9 LIPIDS HEALTH DIS
JI Lipids Health Dis.
PD MAY 14
PY 2020
VL 19
IS 1
AR 94
DI 10.1186/s12944-020-01271-1
PG 10
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA LS1XQ
UT WOS:000536184900003
PM 32410680
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Zaki, SM
   Fattah, SA
   Hassan, DS
AF Zaki, S. M.
   Fattah, S. A.
   Hassan, D. S.
TI The differential effects of high-fat and high-fructose diets on the
   liver of male albino rat and the proposed underlying mechanisms
SO FOLIA MORPHOLOGICA
LA English
DT Article
DE high-fat diet; high-fructose diet; high fructose high-fat diet; liver
ID HEPATIC STEATOSIS; OXIDATIVE STRESS; NONALCOHOLIC STEATOHEPATITIS;
   HEPATOCYTE APOPTOSIS; INDUCED OBESITY; PATHOGENESIS; ACTIVATION;
   EXPRESSION; WEIGHT; FAMILY
AB Background: The Western-style diet is characterised by the high intake of energy-dense foods. Consumption of either high-fructose diet or saturated fat resulted in the development of metabolic syndrome. Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of the metabolic syndrome. Many researchers studied the effect of high-fat diet (HFD), high-fructose diet (HFruD) and high-fructose high-fat diet (HFHF) on the liver. The missing data are the comparison effect of these groups i.e. are effects of the HFHF diet on the liver more pronounced? So, this study was designed to compare the metabolic and histopathological effect of the HFD, HFruD, and HFHF on the liver. The proposed underlying mechanisms involved in these changes were also studied.
   Materials and methods: Twenty four rats were divided into four groups: control, HFD, HFruD, and HFHF. Food was offered for 6 weeks. Biochemical, light microscopic immunohistochemical (Inducible nitric oxide synthase [iNOS] and alpha-smooth muscle actin la-SMAD, real-time polymerase chain reaction (gene expression of TNF-alpha, interleukin-6, Bax, BCL-2, and caspase 3), histomorphometric analysis and oxidative/antioxidative markers (thiobarbituric acid reactive substances [TBARS]malondialdehyde [MDA]/glutathione [GSH] and superoxide dismutase [SOD]) were done.
   Results: The HFD, HFruD and HFHF groups developed a cluster of liver disorders; steatosis, necrosis, inflammation, apoptosis, ballooning degeneration and cytoplasmic vacuolations. Internal metabolic impairments include elevated serum levels of glucose, triglycerides, low density lipoprotein and decreased serum levels of high density lipoprotein and albumin. The immunoreaction of the alpha-SMA and iNOS was strong in these groups. The oxidant markers (MDA and TBARS) were elevated, while the antioxidant markers (SOD and GSH) were decreased. The area per cent of collagen, inflammatory markers, caspase 3 and Bax were elevated, while the BCL-2/Bax ratio was decreased. The decrease in PAS, antioxidant markers and the elevation of the alpha-SMA, iNOS, inflammatory and oxidant markers were obvious in the HFHF when compared to that of the other groups.
   Conclusions: High-fat diet, HFruD, and HFHF developed morphologic hepatic changes ranging from steatosis to necrosis and inflammation, besides the development of internal metabolic impairments. The chief factors of hepatic injury were fat accumulation in the hepatocytes, oxidative stress and highly elevated iNOS. Compared to the other groups, HFHF's effect was more prominent.
C1 [Zaki, S. M.; Fattah, S. A.; Hassan, D. S.] Cairo Univ, Fac Med, Dept Anat & Embryol, Cairo, Egypt.
   [Zaki, S. M.] Fakeeh Coll Med Sci, Jeddah, Saudi Arabia.
C3 Egyptian Knowledge Bank (EKB); Cairo University; Fakeeh College for
   Medical Sciences
RP Zaki, SM (corresponding author), Fakeeh Coll Med Sci, Jeddah, Saudi Arabia.
EM zakysherif1@gmail.com
RI abdelfattah, shereen/AAS-7591-2020; zaki, Sherif/J-5094-2012
OI Abdel Fattah, Shereen/0000-0002-7375-5645; Zaki,
   Sherif/0000-0003-4773-7379
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NR 41
TC 22
Z9 22
U1 0
U2 9
PU VIA MEDICA
PI GDANSK
PA UL SWIETOKRZYSKA 73, 80-180 GDANSK, POLAND
SN 0015-5659
EI 1644-3284
J9 FOLIA MORPHOL
JI Folia Morphol.
PY 2019
VL 78
IS 1
BP 124
EP 136
AR PMID 30009361
DI 10.5603/FM.a2018.0063
PG 13
WC Anatomy & Morphology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Anatomy & Morphology
GA HN2PH
UT WOS:000460026600016
PM 30009361
OA gold
DA 2025-06-11
ER

PT J
AU Schuff, KG
AF Schuff, KG
TI Issues in the diagnosis of Cushing's syndrome for the primary care
   physician
SO PRIMARY CARE
LA English
DT Article
ID CORTICOTROPIN-RELEASING HORMONE; DIFFERENTIAL-DIAGNOSIS; PETROSAL SINUS;
   EPIDEMIOLOGY; DISTINGUISH; STATES
AB The diagnosis of Cushing's syndrome is one of the most difficult and potentially one of the most important made by the primary care physician. Although traditionally considered to be a rare disease (ranging from 1.4 to 10 per million population [1], one small study suggests it may have a prevalence of up to 3% to 4% in the obese, uncontrolled diabetic population [2]. This makes it an important diagnosis to consider as the consequences to the patient are obviously profound, with significant improvements in obesity, diabetes control, hypertension, and neuropsychiatric function observed with surgical cure of the disease and clear excess mortality if left untreated [3].
   The dilemma that faces the primary care physician is how to make this diagnosis in the setting of nonspecific symptoms and physical examination findings, and laboratory tests with fairly good, but not perfect, operating characteristics. The clinical presentation classically described (moon facies, purple striae, central obesity) is uncommonly seen. More often, the clinical presentation of patients proven to have Cushing's syndrome resembles that of much more commonly seen entities, specifically, insulin resistance syndrome, depression, and polycystic ovary syndrome. Thus, the first challenge is to consider the diagnosis. Given the nonspecificity of the clinical presentation and the profound consequences of the disease, it could be argued that screening programs should be instituted. Unfortunately, despite fairly good screening tests, the number of false positives generated from nonselective screening would greatly outnumber the true number of patients with Cushing's syndrome [4]. Rather than screening programs, it is recommended that clinicians have a low threshold for evaluating a patient for Cushing's. However, it must be recognized that the great majority of screened patients will not have the disorder. This article reviews the signs and symptoms of Cushing's syndrome with recommendations on likely candidates for screening and then describes a stepwise approach to follow while making the diagnosis as well as common pitfalls encountered during the diagnostic course.
C1 Oregon Hlth Sci Univ, Div Endocrinol, Portland, OR 97201 USA.
C3 Oregon Health & Science University
RP Schuff, KG (corresponding author), Oregon Hlth Sci Univ, Div Endocrinol, 3181 SW Sam Jackson Pk Rd, Portland, OR 97201 USA.
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NR 20
TC 12
Z9 12
U1 0
U2 2
PU W B SAUNDERS CO
PI PHILADELPHIA
PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA
   19106-3399 USA
SN 0095-4543
J9 PRIMARY CARE
JI Primary Care
PD DEC
PY 2003
VL 30
IS 4
BP 791
EP +
DI 10.1016/S0095-4543(03)00088-5
PG 10
WC Primary Health Care; Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 757GM
UT WOS:000187554700009
PM 15024896
DA 2025-06-11
ER

PT J
AU Thomson, LEJ
   Wei, J
   Agarwal, M
   Haft-Baradaran, A
   Shufelt, C
   Mehta, PK
   Gill, EB
   Johnson, BD
   Kenkre, T
   Handberg, EM
   Li, DB
   Sharif, B
   Berman, DS
   Petersen, JW
   Pepine, CJ
   Merz, CNB
AF Thomson, Louise E. J.
   Wei, Janet
   Agarwal, Megha
   Haft-Baradaran, Afsaneh
   Shufelt, Chrisandra
   Mehta, Puja K.
   Gill, Edward B.
   Johnson, B. Delia
   Kenkre, Tanya
   Handberg, Eileen M.
   Li, Debiao
   Sharif, Behzad
   Berman, Daniel S.
   Petersen, John W.
   Pepine, Carl J.
   Merz, C. Noel Bairey
TI Cardiac Magnetic Resonance Myocardial Perfusion Reserve Index Is Reduced
   in Women With Coronary Microvascular Dysfunction A National Heart, Lung,
   and Blood Institute-Sponsored Study From the Women's Ischemia Syndrome
   Evaluation
SO Circulation-Cardiovascular Imaging
LA English
DT Article
DE magnetic resonance imaging; microvascular angina; myocardial perfusion;
   women
ID SYNDROME EVALUATION WISE; ARTERY-DISEASE; SYNDROME-X; CHEST-PAIN;
   ABSENCE; STRESS; CARDIOMYOPATHY; REACTIVITY; DEFECTS; HUMANS
AB Background-Women with signs and symptoms of ischemia and no obstructive coronary artery disease often have coronary microvascular dysfunction (CMD), diagnosed by invasive coronary reactivity testing (CRT). Although traditional noninvasive stress imaging is often normal in CMD, cardiac MRI may be able to detect CMD in this population.
   Methods and Results-Vasodilator stress cardiac MRI was performed in 118 women with suspected CMD who had undergone CRT and 21 asymptomatic reference subjects. Semi-quantitative evaluation of the first-pass perfusion images was completed to determine myocardial perfusion reserve index (MPRI). The relationship between CRT findings and MPRI was examined by Pearson correlations, logistic regression, and sensitivity/specificity. Symptomatic women had lower mean pharmacological stress MPRI compared with reference subjects (1.71 +/- 0.43 versus 2.23 +/- 0.37; P<0.0001). Lower MPRI was predictive of >= 1 abnormal CRT variables (odds ratio = 0.78 [0.70, 0.88], P<0.0001, c-statistic 0.78 [0.68, 0.88]). An MPRI threshold of 1.84 predicted CRT abnormality with sensitivity 73% and specificity 74%.
   Conclusions-Noninvasive cardiac MRI MPRI can detect CMD defined by invasive CRT. Further work is aimed to optimize the noninvasive identification and management of CMD patients.
C1 [Thomson, Louise E. J.; Wei, Janet; Agarwal, Megha; Haft-Baradaran, Afsaneh; Shufelt, Chrisandra; Mehta, Puja K.; Gill, Edward B.; Berman, Daniel S.; Merz, C. Noel Bairey] Cedars Sinai Med Ctr, Cedars Sinai Heart Inst, Barbra Streisand Womens Heart Ctr, Los Angeles, CA 90048 USA.
   [Johnson, B. Delia; Kenkre, Tanya] Univ Pittsburgh, Sch Publ Hlth, Pittsburgh, PA 15260 USA.
   [Handberg, Eileen M.; Petersen, John W.; Pepine, Carl J.] Univ Florida, Div Cardiol, Gainesville, FL USA.
   [Li, Debiao; Sharif, Behzad] Cedars Sinai Med Ctr, Biomed Imaging Res Inst, Los Angeles, CA 90048 USA.
C3 Cedars Sinai Medical Center; Pennsylvania Commonwealth System of Higher
   Education (PCSHE); University of Pittsburgh; State University System of
   Florida; University of Florida; Cedars Sinai Medical Center
RP Thomson, LEJ (corresponding author), Cedars Sinai Heart Inst, Imaging Ctr, S Mark Taper Fdn, Los Angeles, CA 90048 USA.
EM Louise.Thomson@cshs.org
RI berman, daniel/ABF-0670-2022; Li, Debiao/B-7622-2009
OI Petersen, John/0000-0003-0401-5421; Handberg,
   Eileen/0000-0002-7805-9577; Sharif, Behzad/0000-0002-8945-8178; Shufelt,
   Chrisandra/0000-0001-6886-9210; Pepine, Carl/0000-0002-6011-681X; mehta,
   Puja/0000-0001-9459-9306
FU National Heart, Lung and Blood Institutes from the National Institute on
   Aging [N01-HV-68161, N01-HV-68162, N01-HV-68163, N01-HV-68164,
   K23HL105787, U0164829, U01 HL649141, U01 HL649241, T32HL69751,
   T32HL116273, R01 HL090957, 1R03AG032631]; General Clinical Research
   Center from the National Center for Research Resources [MO1-RR00425];
   Gustavus and Louis Pfeiffer Research Foundation, Danville, NJ
   [UL1TR000124, UL1TR000064]; Women's Guild of Cedars-Sinai Medical
   Center, Los Angeles, CA; Ladies Hospital Aid Society of Western
   Pennsylvania, Pittsburgh, PA; QMED, Inc., Laurence Harbor, NJ;
   Cedars-Sinai Medical Center, Los Angeles, California; Barbra Streisand
   Women's Cardiovascular Research and Education Program, Cedars-Sinai
   Medical Center, Los Angeles; Society for Women's Health Research (SWHR),
   Washington, DC; Linda Joy Pollin Women's Heart Health Program; Erika
   Glazer Women's Heart Health Project, Cedars-Sinai Medical Center, Los
   Angeles
FX This work was supported by contracts from the National Heart, Lung and
   Blood Institutes, nos. N01-HV-68161, N01-HV-68162, N01-HV-68163,
   N01-HV-68164, K23HL105787; grants U0164829, U01 HL649141, U01 HL649241,
   T32HL69751, T32HL116273, R01 HL090957, 1R03AG032631 from the National
   Institute on Aging; General Clinical Research Center grant MO1-RR00425
   from the National Center for Research Resources, UL1TR000124 and
   UL1TR000064, grants from the Gustavus and Louis Pfeiffer Research
   Foundation, Danville, NJ; The Women's Guild of Cedars-Sinai Medical
   Center, Los Angeles, CA; The Ladies Hospital Aid Society of Western
   Pennsylvania, Pittsburgh, PA; and QMED, Inc., Laurence Harbor, NJ; the
   Edythe L. Broad and the Constance Austin Women's Heart Research
   Fellowships, Cedars-Sinai Medical Center, Los Angeles, California; the
   Barbra Streisand Women's Cardiovascular Research and Education Program,
   Cedars-Sinai Medical Center, Los Angeles; The Society for Women's Health
   Research (SWHR), Washington, DC; The Linda Joy Pollin Women's Heart
   Health Program, and the Erika Glazer Women's Heart Health Project,
   Cedars-Sinai Medical Center, Los Angeles.
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NR 26
TC 195
Z9 200
U1 5
U2 14
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1941-9651
EI 1942-0080
J9 CIRC-CARDIOVASC IMAG
JI Circ.-Cardiovasc. Imaging
PD APR
PY 2015
VL 8
IS 4
AR e002481
DI 10.1161/CIRCIMAGING.114.002481
PG 8
WC Cardiac & Cardiovascular Systems; Radiology, Nuclear Medicine & Medical
   Imaging
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Radiology, Nuclear Medicine &
   Medical Imaging
GA CG5CX
UT WOS:000353309800003
PM 25801710
OA Bronze, Green Accepted
DA 2025-06-11
ER

PT J
AU Zhang, MM
   Yang, AM
AF Zhang, Mengmeng
   Yang, Aiming
TI Association between oxidative balance score and gallstone disease: a
   population-based study from NHANES
SO FRONTIERS IN NUTRITION
LA English
DT Article
DE oxidative balance score; diet; lifestyle; gallstones; NHANES
ID CARDIOMETABOLIC RISK-FACTORS; STRESS; CHOLELITHIASIS; INFLAMMATION;
   MECHANISMS; MAGNESIUM
AB Background Oxidative stress has been reported to participant in the pathogenesis of gallstones. Oxidative balance score (OBS) represents pro-oxidant and antioxidant exposures to diet and lifestyle, closely associated with multiple metabolic disorders. However, the relationship between OBS and gallstones remains unclear.Methods This study analyzed cross-sectional data from the National Health and Nutrition Examination Survey (NHANES) 2017-2020. OBS was calculated based on the 24-h recall interviews or questionnaires. We used weighted logistic regression, restricted cubic splines (RCS), weighted quantile sum (WQS) regression and the Bayesian kernel machine regression (BKMR) model to identify the relationship between OBS and gallstones. Subgroup analysis and sensitivity analysis were used to explore potential heterogeneity and stability of the results. Mediation analysis was performed to assess the mediating effects of serum lipid in the association between OBS and gallstones.Results A total of 7,618 participants were finally included in this study. Weighted logistics regression showed that total OBS was associated with gallstones risk (OR = 0.98, p = 0.03), particularly in individuals who were under 60 years old, Hispanic, educated below high school, non-smokers, had hypertension or malignancy. Dietary and lifestyle OBS independently contribute to the protection against gallstones. RCS analysis indicated a non-linear relationship between OBS and gallstones (p = 0.03). WQS and BKMR model identified that BMI, vitamin E, vitamin B6, magnesium and carotene played relatively important role among 20 components. Mediation analysis showed serum TG and HDL as mediators of the association between OBS and gallstones.Conclusion Higher OBS or increased oxidative balance are positively associated with reduction of gallstone risk. This findings provide valuable insights for surveillance and interventions targeting for antioxidant-rich diet and lifestyle for gallstone disease.
C1 [Zhang, Mengmeng; Yang, Aiming] Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Gastroenterol, Beijing, Peoples R China.
C3 Chinese Academy of Medical Sciences - Peking Union Medical College;
   Peking Union Medical College Hospital; Peking Union Medical College
RP Yang, AM (corresponding author), Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Gastroenterol, Beijing, Peoples R China.
EM yangam2020@126.com
FU National Key Research and Development Program of China [2022YFC3602103];
   National High-Level Hospital Clinical Research Funding
   [2022-PUMCH-B-024]; National Key Clinical Specialty Construction Project
   [ZK108000]; Peking Union Medical College Hospital Research Funding for
   Postdoc [KYFYJJ202406]
FX The author(s) declare that financial support was received for the
   research, authorship, and/or publication of this article. This study was
   supported by National Key Research and Development Program of China
   (2022YFC3602103), National High-Level Hospital Clinical Research Funding
   (2022-PUMCH-B-024), National Key Clinical Specialty Construction Project
   (ZK108000), and Peking Union Medical College Hospital Research Funding
   for Postdoc (KYFYJJ202406).
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NR 60
TC 1
Z9 1
U1 5
U2 5
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD JAN 22
PY 2025
VL 12
AR 1539969
DI 10.3389/fnut.2025.1539969
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA U7B1G
UT WOS:001413292200001
PM 39911802
OA gold
DA 2025-06-11
ER

PT J
AU LeCroy, MN
   Strizich, GM
   Gallo, LC
   Perreira, KP
   Ayala, GX
   Carnethon, MR
   Delamater, AM
   Gonzalez, JS
   Arredondo, EM
   Pulgaron, ER
   Isasi, CR
AF LeCroy, Madison N.
   Strizich, Garrett M.
   Gallo, Linda C.
   Perreira, Krista P.
   Ayala, Guadalupe X.
   Carnethon, Mercedes R.
   Delamater, Alan M.
   Gonzalez, Jeffrey S.
   Arredondo, Elva M.
   Pulgaron, Elizabeth R.
   Isasi, Carmen R.
TI The Association of the Parent Child Language Acculturation Gap with
   Obesity and Cardiometabolic Risk in Hispanic/Latino Youth: Results from
   the Hispanic Community Children's Health Study/Study of Latino Youth
   (SOL Youth)
SO ANNALS OF BEHAVIORAL MEDICINE
LA English
DT Article
DE Hispanics; Parent-child relations; Acculturation; Child; Youth; Language
ID UNITED-STATES; CARDIOVASCULAR-DISEASE; AMERICANS; STRESS; DESIGN;
   HISPANICS/LATINOS; OPPORTUNITIES; RELIABILITY; CONSUMPTION; ADJUSTMENT
AB Background Hispanic/Latino youth are disproportionately burdened by obesity and have a high prevalence of prediabetes and dyslipidemia. Differences in parent and child acculturation related to language use and preference (i.e., language acculturation) are associated with adverse cardiometabolic health behaviors, but no study has examined associations with cardiometabolic markers.
   Purpose To determine whether discordance in parent-child language acculturation (parent-child acculturation gap) was associated with poor youth cardiometabolic health.
   Methods Hispanic/Latino 8-16-year-olds (n = 1,466) and parents from the Hispanic Community Children's Health Study/Study of Latino Youth (SOL Youth) were examined. Mean scores for the Brief ARSMA-II's Anglo (AOS) and Latino (LOS) Orientation Scales represented language acculturation. Cardiometabolic markers included youth body mass index (BMI) percentile, blood pressure percentiles, and dysglycemia and hyperlipidemia measures. Missing data were imputed. Survey-weighted multivariable linear regression examined the association of youth, parent, and youth x parent (the acculturation gap) AOS and LOS scores separately with each cardiometabolic marker.
   Results Youth reported greater English and lower Spanish use than parents. Greater discordance in AOS scores was associated with elevated BMI percentile only (p-for-interaction < .01). The LOS acculturation gap was not associated with any outcome. Adjustment for acculturative stress, family functioning and closeness, parenting style, and youth's diet and physical activity did not alter findings. Removal of nonsignificant acculturation gaps did not indicate an association between individual youth or parent AOS or LOS scores and any cardiometabolic marker.
   Conclusions Discordance in Hispanic/Latino parent-child dyads' English use may relate to increased risk for childhood obesity. Future studies should identify mediators of this association.
C1 [LeCroy, Madison N.; Gonzalez, Jeffrey S.; Isasi, Carmen R.] Albert Einstein Coll Med, Dept Epidemiol & Populat Hlth, 1300 Morris Pk Ave, Bronx, NY 10461 USA.
   [Strizich, Garrett M.] Univ Washington, Sch Med, 1959 NE Pacific St, Seattle, WA 98195 USA.
   [Gallo, Linda C.] San Diego State Univ, Dept Psychol, 5500 Campanile Dr, San Diego, CA 92182 USA.
   [Perreira, Krista P.] Univ N Carolina, Dept Social Med, Sch Med, 333 South Columbia St,CB 7240, Chapel Hill, NC 27599 USA.
   [Ayala, Guadalupe X.; Arredondo, Elva M.] San Diego State Univ, Sch Publ Hlth, Div Hlth Promot & Behav Sci, 5500 Campanile Dr, San Diego, CA 92182 USA.
   [Carnethon, Mercedes R.] Northwestern Univ, Dept Prevent Med, 680 N Lake Shore Dr, Chicago, IL 60611 USA.
   [Delamater, Alan M.; Pulgaron, Elizabeth R.] Univ Miami, Mailman Ctr Child Dev, Miller Sch Med, Dept Pediat, 1601 NW 12th Ave, Miami, FL 33136 USA.
   [Gonzalez, Jeffrey S.] Albert Einstein Coll Med, Dept Med, 1300 Morris Pk Ave, Bronx, NY 10461 USA.
   [Gonzalez, Jeffrey S.] Yeshiva Univ, Ferkauf Grad Sch Psychol, 1165 Morris Pk Ave, Bronx, NY 10461 USA.
C3 Montefiore Medical Center; Albert Einstein College of Medicine; Yeshiva
   University; University of Washington; University of Washington Seattle;
   California State University System; San Diego State University;
   University of North Carolina; University of North Carolina Chapel Hill;
   University of North Carolina School of Medicine; California State
   University System; San Diego State University; Northwestern University;
   University of Miami; Yeshiva University; Montefiore Medical Center;
   Albert Einstein College of Medicine; Yeshiva University
RP LeCroy, MN (corresponding author), Albert Einstein Coll Med, Dept Epidemiol & Populat Hlth, 1300 Morris Pk Ave, Bronx, NY 10461 USA.
EM madison.lecroy@einsteinmed.org
OI Gallo, Linda C./0000-0002-3678-5888; Perreira,
   Krista/0000-0003-2906-0261; LeCroy, Madison/0000-0001-7121-4207
FU National Heart, Lung, and Blood Institute (NHLBI) [R01HL102130]; NHLBI
   [N01-HC65233, N01-HC65234, N01-HC65235, N01-HC65236, N01-HC65237];
   National Center on Minority Health and Health Disparities; National
   Institute of Deafness and Other Communications Disorders; National
   Institute of Dental and Craniofacial Research; National Institute of
   Diabetes and Digestive and Kidney Diseases; National Institute of
   Neurologic Disorders and Stroke; Office of Dietary Supplements; Life
   Course Methodology Core (LCMC) at Albert Einstein College of Medicine;
   New York Regional Center for Diabetes Translation Research through funds
   from the National Institute of Diabetes and Digestive and Kidney
   Diseases [P30 DK111022-8786, P30 DK111022]; NHLBI training grant
   [T32HL144456]
FX SOL Youth was supported by grant R01HL102130 from the National Heart,
   Lung, and Blood Institute (NHLBI). The children in SOL Youth are drawn
   from the study of adults, The Hispanic Community Health Study/Study of
   Latinos, which was supported by contracts from the NHLBI to the
   University of North Carolina (N01-HC65233), University of Miami
   (N01-HC65234), Albert Einstein College of Medicine (N01-HC65235),
   Northwestern University (N01-HC65236), and San Diego State University
   (N01-HC65237). The following Institutes/Centers/Offices contributed to
   the HCHS/SOL through a transfer of funds to NHLBI: National Center on
   Minority Health and Health Disparities, the National Institute of
   Deafness and Other Communications Disorders, the National Institute of
   Dental and Craniofacial Research, the National Institute of Diabetes and
   Digestive and Kidney Diseases, the National Institute of Neurologic
   Disorders and Stroke, and the Office of Dietary Supplements. Additional
   support was provided by the Life Course Methodology Core (LCMC) at
   Albert Einstein College of Medicine and the New York Regional Center for
   Diabetes Translation Research (P30 DK111022-8786 and P30 DK111022)
   through funds from the National Institute of Diabetes and Digestive and
   Kidney Diseases. Support for the lead author was provided by an NHLBI
   training grant (T32HL144456). The content is solely the responsibility
   of the authors and does not necessarily represent the official views of
   the NHLBI or the National Institutes of Health.
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NR 71
TC 8
Z9 9
U1 1
U2 1
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0883-6612
EI 1532-4796
J9 ANN BEHAV MED
JI Ann. Behav. Med.
PD AUG
PY 2021
VL 55
IS 8
BP 734
EP 745
DI 10.1093/abm/kaaa114
EA JAN 2021
PG 12
WC Psychology, Multidisciplinary
WE Social Science Citation Index (SSCI)
SC Psychology
GA XT8KW
UT WOS:000733831000004
PM 33449084
OA Green Published
DA 2025-06-11
ER

PT J
AU Abu Dabrh, A
   Haga, CB
   Conrad, J
   Perlman, AI
   Allyse, MA
   Albertie, ML
   Martinez-Heath, M
   Ball, CT
   Willis, FB
AF Abu Dabrh, Abd Moain
   Haga, Claire B.
   Conrad, Jarik
   Perlman, Adam I.
   Allyse, Megan A.
   Albertie, Monica L.
   Martinez-Heath, Maia
   Ball, Colleen T.
   Willis, Floyd B.
TI Nutrition and Emotional Health Education: The Use of Emotional
   Intelligence and a Plant-Based Diet to Reduce Cardiometabolic Risk
SO GLOBAL ADVANCES IN INTEGRATIVE MEDICINE AND HEALTH
LA English
DT Article
DE cardiometabolic; emotional intelligence; nutritional intervention;
   coaching; plant-based nutrition
ID WEIGHT-LOSS; INCREMENTAL VALIDITY; STRESS; INTERVENTION; METAANALYSIS;
   PERFORMANCE; IMPACT
AB Background: For individuals living with chronic conditions like diabetes mellitus and obesity, there is a need for sustainable behavioral strategies and physiologic tools. These tools support identifying and addressing barriers to healthy eating, reducing body mass index (BMI), and building increased physical resilience in real time. Objective: To evaluate whether a 12-week learning management system designed to combine nutritional intervention with education and coaching on improving emotional intelligence (EI) could alter cardiometabolic outcomes. MethodsThis pre-post prospective study enrolled 37 adult volunteers with BMI greater than 25 to participate in a 12-week learning management system. Primary (BMI, systolic blood pressure, diastolic blood pressure, low-density lipoprotein [LDL], high-density lipoprotein, and fasting glucose levels) and secondary self-reported outcomes were assessed at baseline, 12 weeks, and 6 months after enrollment using Short Form-36, Emotional Quotient Inventory (EQi), and Whole Health Index (WHI). Linear mixed-effects regression models with random effect were used to estimate changes in primary and secondary outcomes. We adjusted for multiple testing using Holm step-down method. Results: BMI and LDL were the only primary endpoints lower at program completion and 6-month follow-up compared to baseline levels (-1.63 and -17.77 mg/dL, respectively; P < .001). Secondary outcomes showing statistically significant improvement from baseline to 6-month follow-up included energy/fatigue (Short Form-36), self-regard (EQi), decision-making (EQi), impulse control (EQi), stress management (EQi), Whole Brain - Form A (WHI), Whole Food - Form C (WHI), and Whole Body - Form D (WHI). Conclusion: This study provides preliminary evidence that lifestyle programs combining nutritional interventions and EI can have a significant impact on BMI and LDL. Our study highlights the potential importance of both nutrition and EI in programs targeting diet and lifestyle modification.
C1 [Abu Dabrh, Abd Moain; Perlman, Adam I.] Mayo Clin, Div Gen Internal Med, 4500 San Pablo Rd, Jacksonville, FL 32224 USA.
   [Haga, Claire B.; Martinez-Heath, Maia; Willis, Floyd B.] Mayo Clin, Dept Family Med, Jacksonville, FL 32224 USA.
   [Conrad, Jarik; Allyse, Megan A.; Ball, Colleen T.] Mayo Clin, Dept Quantitat Hlth Sci, Jacksonville, FL 32224 USA.
   [Albertie, Monica L.] Mayo Clin, Dept Res, Community Outreach & Engagement, Jacksonville, FL 32224 USA.
C3 Mayo Clinic; Mayo Clinic; Mayo Clinic; Mayo Clinic
RP Abu Dabrh, A (corresponding author), Mayo Clin, Div Gen Internal Med, 4500 San Pablo Rd, Jacksonville, FL 32224 USA.
EM AbuDabrh.AbdMoain@mayo.edu
RI Allyse, Megan/H-7207-2019; Abu Dabrh, Abd Moain/J-1749-2014
FX The Scientific Publications staff at Mayo Clinic provided copyediting,
   proofreading, administrative, and clerical support.
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NR 52
TC 1
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PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
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J9 GLOB ADV INTEGR MED
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PD NOV
PY 2023
VL 12
AR 27536130231215014
DI 10.1177/27536130231215014
PG 10
WC Integrative & Complementary Medicine
WE Emerging Sources Citation Index (ESCI)
SC Integrative & Complementary Medicine
GA F9C0S
UT WOS:001312698100003
PM 38026440
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Weiss, EP
   Fontana, L
AF Weiss, Edward P.
   Fontana, Luigi
TI Caloric restriction: powerful protection for the aging heart and
   vasculature
SO AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
LA English
DT Review
DE cardiovascular disease; inflammation; oxidative stress; arterial
   stiffness; cardiovascular aging
ID NF-KAPPA-B; RANDOMIZED CONTROLLED-TRIAL; AGE-RELATED-CHANGES; MONKEYS
   MACACA-FASCICULARIS; CORONARY-ARTERY-DISEASE; LOW-DENSITY-LIPOPROTEIN;
   NITRIC-OXIDE SYNTHASE; INCIDENT CARDIOVASCULAR EVENTS;
   ENDOTHELIUM-DEPENDENT DILATION; BLOOD-PRESSURE VARIABILITY
AB Weiss EP, Fontana L. Caloric restriction: powerful protection for the aging heart and vasculature. Am J Physiol Heart Circ Physiol 301: H1205-H1219, 2011. First published August 12, 2011; doi: 10.1152/ajpheart.00685.2011.-Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in the United States. Research has shown that the majority of the cardiometabolic alterations associated with an increased risk of CVD (e.g., insulin resistance/type 2 diabetes, abdominal obesity, dyslipidemia, hypertension, and inflammation) can be prevented, and even reversed, with the implementation of healthier diets and regular exercise. Data from animal and human studies indicate that more drastic interventions, i.e., calorie restriction with adequate nutrition (CR), may have additional beneficial effects on several metabolic and molecular factors that are modulating cardiovascular aging itself (e.g., cardiac and arterial stiffness and heart rate variability). The purpose of this article is to review the current knowledge on the effects of CR on the aging of the cardiovascular system and CVD risk in rodents, monkeys, and humans. Taken together, research shows that CR has numerous beneficial effects on the aging cardiovascular system, some of which are likely related to reductions in inflammation and oxidative stress. In the vasculature, CR appears to protect against endothelial dysfunction and arterial stiffness and attenuates atherogenesis by improving several cardiometabolic risk factors. In the heart, CR attenuates age-related changes in the myocardium (i.e., CR protects against fibrosis, reduces cardiomyocyte apoptosis, prevents myosin isoform shifts, etc.) and preserves or improves left ventricular diastolic function. These effects, in combination with other benefits of CR, such as protection against obesity, diabetes, hypertension, and cancer, suggest that CR may have a major beneficial effect on health span, life span, and quality of life in humans.
C1 [Weiss, Edward P.] St Louis Univ, Dept Nutr & Dietet, St Louis, MO 63104 USA.
   [Weiss, Edward P.; Fontana, Luigi] Washington Univ, Sch Med, Dept Med, Div Geriatr & Nutr Sci, St Louis, MO 63110 USA.
   [Fontana, Luigi] Ist Super Sanita, Div Nutr & Aging, I-00161 Rome, Italy.
C3 Saint Louis University; Washington University (WUSTL); Istituto
   Superiore di Sanita (ISS)
RP Weiss, EP (corresponding author), St Louis Univ, Doisy Coll Hlth Sci, Dept Nutr & Diabet, St Louis, MO 63104 USA.
EM eweiss4@slu.edu
RI Weiss, Edward/P-1682-2017; Fontana, Luigi/K-4773-2013
OI Fontana, Luigi/0000-0001-8500-5537
FU National Institutes of Health [UL1-RR-024992, P30-DK-056341,
   K01-DK-080886]; Istituto Superiore di Sanita/National Institutes of
   Health; Ministero della Salute; Longer Life Foundation; Bakewell
   Foundation; Scott and Annie Appleby Charitable Trust
FX This study was supported by National Institutes of Health Grants
   UL1-RR-024992, P30-DK-056341, and K01-DK-080886; by grants from Istituto
   Superiore di Sanita/National Institutes of Health Collaboration Program,
   Ministero della Salute, the Longer Life Foundation (an RGA/Washington
   University Partnership), and the Bakewell Foundation; and by a donation
   from the Scott and Annie Appleby Charitable Trust. The funding agencies
   provided financial support to the authors for their time in writing this
   manuscript and for their research on the effects of calorie restriction
   on the cardiovascular system but had no role in the analysis or
   interpretation of data or in the writing of this review article.
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NR 217
TC 138
Z9 156
U1 1
U2 28
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0363-6135
EI 1522-1539
J9 AM J PHYSIOL-HEART C
JI Am. J. Physiol.-Heart Circul. Physiol.
PD OCT
PY 2011
VL 301
IS 4
BP H1205
EP H1219
DI 10.1152/ajpheart.00685.2011
PG 15
WC Cardiac & Cardiovascular Systems; Physiology; Peripheral Vascular
   Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Physiology
GA 826NE
UT WOS:000295360100002
PM 21841020
OA Green Published
DA 2025-06-11
ER

PT J
AU Aker, A
   Saliba, W
   Bahouth, F
   Naoum, I
   Zafrir, B
AF Aker, Amir
   Saliba, Walid
   Bahouth, Fadel
   Naoum, Ibrahim
   Zafrir, Barak
TI Cardiorespiratory Fitness and Risk of Cardiovascular Events and
   Mortality in Middle Age Patients without Known Cardiovascular Disease
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Article
DE exercise stress testing; fitness; cardiovascular disease; outcome;
   prognosis
ID ALL-CAUSE MORTALITY; EXERCISE CAPACITY; HEALTHY-MEN
AB Background: Low cardiorespiratory fitness is an established risk predictor for chronic non-communicable diseases. We aimed to investigate the prognostic significance of fitness level on the risk of major adverse cardiac events (MACE, the composite of myocardial infarction, stroke, or all-cause death), in a contemporary cohort of middle-aged subjects without cardiovascular disease. Methods: Retrospective analysis of patients aged 40-60 years without a history of cardiovascular disease. Degree of fitness was determined according to a graded, maximal treadmill exercise stress testing (EST) time achieved, classified into age- and sex-specific quintiles (Q), and categorized as low (Q1), moderate (Q2-Q4) or high (Q5) fitness groups. A multivariable Cox proportional hazard regression model was used to assess the association of fitness level with the risk of MACE. Results: A total of 6836 patients were included, of which 44.5% were women, and the mean age was 52 years. Overall, 289 MACE events occurred during a median follow-up of 7 years. Level of fitness was inversely associated with the presence of cardiovascular risk factors. The multivariable adjusted hazard ratio (95% confidence interval) for MACE was 1.65 (1.12-2.44) and 2.17 (1.40-3.38) in those at moderate and low fitness levels, compared to the high-fitness group (reference), respectively. For each decrease of one metabolic equivalent (MET) unit achieved at peak exercise, the relative risk for MACE increased by 18%. The association between low fitness and MACE was not modified by other risk factors (P-for-interaction non-significant). Conclusions: Low fitness level, as captured by a maximal treadmill EST, is an independent risk predictor for MACE among middle-age individuals without known cardiovascular disease. The association of low fitness with high burden of cardiometabolic risk factors highlight the importance of lifestyle intervention in this patient population.
C1 [Aker, Amir; Naoum, Ibrahim; Zafrir, Barak] Lady Davis Carmel Med Ctr, Dept Cardiol, IL-3436212 Haifa, Israel.
   [Saliba, Walid] Lady Davis Carmel Med Ctr, Dept Community Med & Epidemiol, IL-3436212 Haifa, Israel.
   [Saliba, Walid; Zafrir, Barak] Technion Israel Inst Technol, Fac Med, IL-3525433 Haifa, Israel.
   [Bahouth, Fadel] EMMS Nazareth Hosp, Dept Cardiol, IL-16100 Nazareth, Israel.
C3 Clalit Health Services; Carmel Medical Center; Clalit Health Services;
   Carmel Medical Center; Technion Israel Institute of Technology
RP Zafrir, B (corresponding author), Lady Davis Carmel Med Ctr, Dept Cardiol, IL-3436212 Haifa, Israel.; Zafrir, B (corresponding author), Technion Israel Inst Technol, Fac Med, IL-3525433 Haifa, Israel.
EM barakzmd@gmail.com
RI Zafrir, Barak/AAF-3423-2020; Aker, Amir/LXW-7070-2024
OI Zafrir, Barak/0000-0002-2391-8397; Aker, Amir/0000-0002-3724-6691;
   Naoum, Ibrahim/0009-0007-2929-4873; Bahouth, Fadel/0000-0003-4353-9703
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NR 22
TC 5
Z9 6
U1 0
U2 2
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD NOV
PY 2023
VL 12
IS 22
AR 7011
DI 10.3390/jcm12227011
PG 10
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA Z9QT0
UT WOS:001115359800001
PM 38002625
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Lendvai, D
   Whittemore, R
   Womack, JA
   Fortier, CB
   Milberg, WP
   Fonda, JR
AF Lendvai, Dora
   Whittemore, Robin
   Womack, Julie A.
   Fortier, Catherine B.
   Milberg, William P.
   Fonda, Jennifer R.
TI The Impact of Blast Exposure-With or Without Traumatic Brain Injury-on
   Metabolic Abnormalities in Post-9/11 Veterans
SO JOURNAL OF HEAD TRAUMA REHABILITATION
LA English
DT Article
DE blast injuries; cardiometabolic risk factors; glucose metabolism
   disorders; obesity; secondary prevention; September 11 terrorist
   attacks; traumatic brain injuries; veterans' health
ID POSTTRAUMATIC-STRESS-DISORDER; BODY-MASS INDEX; PTSD; ASSOCIATIONS;
   PERSONALITY; INTERVIEW; EXERCISE; RISK
AB Objective: The primary aim included explorations of: (1) the associations between the history of blast exposure (BE), close blast exposure (CBE), and blast-related traumatic brain injury (bTBI) and metabolic abnormality; and (2) the potential mediating effect of comorbid psychological and somatic conditions on these associations. The secondary aim explored the association of dose-response impact of BE, CBE, and bTBI and metabolic abnormality. Setting: Data were collected by the Translational Research Center for TBI and Stress Disorders (TRACTS). Participants: Post-9/11 veterans from the TRACTS baseline sample who had conflict-zone deployment experience (N = 734). Design: Cross-sectional secondary data analysis. We computed relative risks (RRs) and 95% CI using modified Poisson regression. We quantified the impact of co-occurring psychological and somatic conditions on this association using mediation analyses. Main Measures: Exposures included BE (<100 m), CBE (<10 m), and bTBI. Metabolic abnormality outcomes included (1) overweight/obesity (defined by abnormal waist-hip ratio [WHR] and abnormal waist circumference [WC]); (2) glucose dysregulation; and (3) meeting criteria for cardiometabolic syndrome (defined by guidelines). Results: The sample was majority male (91%) and White (68%), with a mean age of 34.6 years (SD = 8.99). Most participants had 1 or more BE (83%); 48% experienced 1 or more CBE. Overweight/obesity was highly prevalent in the sample (51% had abnormal WHR and 60% abnormal WC). There was no significant direct or indirect association between BE, CBE, and bTBI and metabolic abnormalities (RRs: 0.70-1.51; P's >.05). Conclusion: Future research is needed to investigate the association of BE with metabolic abnormalities with larger, more targeted sample selection, and longer follow-up. Effective and sustainable weight management and metabolic health prevention interventions for this veteran cohort are needed.
C1 [Lendvai, Dora; Womack, Julie A.] VA Connecticut Healthcare Syst, West Haven, CT USA.
   [Lendvai, Dora; Whittemore, Robin; Womack, Julie A.] Yale Univ, Sch Nursing, Orange, CT USA.
   [Fortier, Catherine B.; Milberg, William P.; Fonda, Jennifer R.] VA Boston Healthcare Syst, Translat Res Ctr TBI & Stress Disorders & Geriatr, Educ & Clin Ctr, Boston, MA USA.
   [Fonda, Jennifer R.] Boston Univ, Sch Med, Dept Psychiat, Boston, MA USA.
   [Fortier, Catherine B.; Milberg, William P.; Fonda, Jennifer R.] Harvard Med Sch, Dept Psychiat, Boston, MA USA.
   [Lendvai, Dora] VA Connecticut Healthcare Syst, West Haven, CT 06516 USA.
C3 US Department of Veterans Affairs; Veterans Health Administration (VHA);
   VA Connecticut Healthcare System; Yale University; Harvard University;
   Harvard University Medical Affiliates; US Department of Veterans
   Affairs; Veterans Health Administration (VHA); VA Boston Healthcare
   System; Boston University; Harvard University; Harvard Medical School;
   US Department of Veterans Affairs; Veterans Health Administration (VHA);
   VA Connecticut Healthcare System
RP Lendvai, D (corresponding author), VA Connecticut Healthcare Syst, West Haven, CT 06516 USA.
EM dora.lendvai@va.gov; robin.whittemore@yale.edu; julie.womack@yale.edu;
   Catherine_Fortier@hms.harvard.edu; william_milberg@hms.harvard.edu;
   jennifer.fonda@va.gov
RI Fonda, Jennifer/ABG-2890-2021; Fortier, Catherine/AAS-2163-2021
OI Lendvai, Dora/0000-0002-5712-6638; Fonda, Jennifer/0000-0001-9482-2918
FU United States Department of Veterans Affairs (VA), through the
   Translational Research Center for Traumatic Brain Injury and Stress
   Disorders (TRACTS); VA Rehabilitation Research and Development Traumatic
   Brain Injury National Research Center [B3001-C]; National Institute of
   Health/National Institute of Nursing Research under the Ruth L.
   Kirschstein National Research Service Award [F31-NR019934-01]; National
   Institute of Arthritis and Musculoskeletal and Skin Diseases [R01
   AR078715]; Department of VA Clinical Science Research amp; Development
   Career Development Award [IK2CX002192-01A2]; VA Rehabilitation Research
   amp; Development Research Merit Award [RX-0029 07]
FX This research was supported by the United States Department of Veterans
   Affairs (VA), through the Translational Research Center for Traumatic
   Brain Injury and Stress Disorders (TRACTS), the VA Rehabilitation
   Research and Development Traumatic Brain Injury National Research Center
   (B3001-C). Dora Lendvai received funding from the National Institute of
   Health/National Institute of Nursing Research under the Ruth L.
   Kirschstein & nbsp;National Research Service Award (F31-NR019934-01).
   Julie A. Womack received funding from the National Institute of
   Arthritis and Musculoskeletal and Skin Diseases (R01 AR078715). Jennifer
   R. Fonda received funding from the Department of VA Clinical Science
   Research & Development Career Development Award (IK2CX002192-01A2).
   Catherine B. Fortier received funding from the VA Rehabilitation
   Research & Development Research Merit Award (RX-0029 07). Note: these
   funding agencies have public and open access policies that we are
   required to fulfill.
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NR 49
TC 1
Z9 1
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0885-9701
EI 1550-509X
J9 J HEAD TRAUMA REHAB
JI J. Head Trauma Rehabil.
PD SEP-OCT
PY 2023
VL 38
IS 5
SI SI
BP 380
EP 390
DI 10.1097/HTR.0000000000000874
PG 11
WC Clinical Neurology; Rehabilitation
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Rehabilitation
GA R3OK1
UT WOS:001063476500003
PM 36951458
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Axelrod, CL
   Dantas, WS
   Kirwan, JP
AF Axelrod, Christopher L.
   Dantas, Wagner S.
   Kirwan, John P.
TI Sarcopenic obesity: emerging mechanisms and therapeutic potential
SO METABOLISM-CLINICAL AND EXPERIMENTAL
LA English
DT Review
DE Sarcopenia; Obesity; Sarcopenic obesity; Aging; Muscle mass; Muscle
   function; Mitochondrial quality control
ID FATTY-ACID OXIDATION; WHOLE-BODY ELECTROMYOSTIMULATION; SKELETAL-MUSCLE
   HYPERTROPHY; ANABOLIC RESISTANCE; INSULIN-RESISTANCE; OLDER-ADULTS;
   KAPPA-B; METABOLIC SYNDROME; LIPID-CONTENT; FIBER TYPE
AB Sarcopenic obesity, or the loss of muscle mass and function associated with excess adiposity, is a largely untreatable medical condition associated with diminished quality of life and increased risk of mortality. To date, it remains somewhat paradoxical and mechanistically undefined as to why a subset of adults with obesity develop muscular decline, an anabolic stimulus generally associated with retention of lean mass. Here, we review evidence surrounding the definition, etiology, and treatment of sarcopenic obesity with an emphasis on emerging regulatory nodes with therapeutic potential. We review the available clinical evidence largely focused on diet, lifestyle, and behavioral interventions to improve quality of life in patients with sarcopenic obesity. Based upon available evidence, relieving consequences of energy burden, such as oxidative stress, myosteatosis, and/or mitochondrial dysfunction, is a promising area for therapeutic development in the treatment and management of sarcopenic obesity.
C1 [Axelrod, Christopher L.; Dantas, Wagner S.; Kirwan, John P.] Pennington Biomed Res Ctr, Integrated Physiol & Mol Med Lab, Baton Rouge, LA USA.
   [Kirwan, John P.] Pennington Biomed Res Ctr, Integrated Physiol & Mol Med Lab, 6400 Perkins Rd, Baton Rouge, LA 70808 USA.
C3 Louisiana State University System; Louisiana State University;
   Pennington Biomedical Research Center; Louisiana State University
   System; Louisiana State University; Pennington Biomedical Research
   Center
RP Kirwan, JP (corresponding author), Pennington Biomed Res Ctr, Integrated Physiol & Mol Med Lab, 6400 Perkins Rd, Baton Rouge, LA 70808 USA.
EM john.kirwan@pbrc.edu
RI Dantas, Wagner/AEQ-8169-2022; Kirwan, John/G-6942-2012
FU National Institute of Health [R01 DK108089, U54 GM104940]
FX <B>Funding</B> This research was supported by National Institute of
   Health grants R01 DK108089 (JPK) and U54 GM104940 (JPK) .
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NR 153
TC 52
Z9 53
U1 4
U2 16
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0026-0495
EI 1532-8600
J9 METABOLISM
JI Metab.-Clin. Exp.
PD SEP
PY 2023
VL 146
AR 155639
DI 10.1016/j.metabol.2023.155639
EA JUN 2023
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA EW0F7
UT WOS:001141844700001
PM 37380015
OA hybrid
DA 2025-06-11
ER

PT J
AU Wang, XF
   Qi, Y
   Zheng, H
AF Wang, Xiaofei
   Qi, Yue
   Zheng, Hao
TI Dietary Polyphenol, Gut Microbiota, and Health Benefits
SO ANTIOXIDANTS
LA English
DT Review
DE dietary polyphenols; host health; gut microbiota; biotransformation
ID RED WINE POLYPHENOLS; CHAIN FATTY-ACIDS; FECAL MICROBIOTA; INTESTINAL
   MICROBIOTA; INSULIN-RESISTANCE; METABOLIC SYNDROME; OXIDATIVE STRESS;
   INDUCED OBESITY; BLACK TEA; RESVERATROL
AB Polyphenols, which are probably the most important secondary metabolites produced by plants, have attracted tremendous attention due to their health-promoting effects, including their antioxidant, anti-inflammatory, antibacterial, anti-adipogenic, and neuro-protective activities, as well as health properties. However, due to their complicated structures and high molecular weights, a large proportion of dietary polyphenols remain unabsorbed along the gastrointestinal tract, while in the large intestine they are biotransformed into bioactive, low-molecular-weight phenolic metabolites through the residing gut microbiota. Dietary polyphenols can modulate the composition of intestinal microbes, and in turn, gut microbes catabolize polyphenols to release bioactive metabolites. To better investigate the health benefits of dietary polyphenols, this review provides a summary of their modulation through in vitro and in vivo evidence (animal models and humans), as well as their possible actions through intestinal barrier function and gut microbes. This review aims to provide a basis for better understanding the relationship between dietary polyphenols, gut microbiota, and host health.
C1 [Wang, Xiaofei; Qi, Yue; Zheng, Hao] China Agr Univ, Coll Food Sci & Nutr Engn,Beijing Key Lab Food No, Natl Engn Technol Res Ctr Fruit & Vegetable Proc, Key Open Lab Fruit & Vegetable Proc,Minist Agr &, Beijing 100083, Peoples R China.
C3 Ministry of Agriculture & Rural Affairs; China Agricultural University
RP Zheng, H (corresponding author), China Agr Univ, Coll Food Sci & Nutr Engn,Beijing Key Lab Food No, Natl Engn Technol Res Ctr Fruit & Vegetable Proc, Key Open Lab Fruit & Vegetable Proc,Minist Agr &, Beijing 100083, Peoples R China.
EM xiaofei.wang@cau.edu.cn; qiyue@cau.edu.cn; hao.zheng@cau.edu.cn
RI qi, yue/KLE-0386-2024; Wang, Xiaofei/IQT-2863-2023; Zheng,
   Hao/ABA-8266-2021
OI Zheng, Hao/0000-0003-3313-1675; Wang, Xiaofei/0000-0003-3074-3860
FU Chinese Universities Scientific Fund [2022TC072]
FX This research was funded by Chinese Universities Scientific Fund, grant
   number 2022TC072.
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NR 138
TC 183
Z9 190
U1 49
U2 340
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD JUN
PY 2022
VL 11
IS 6
AR 1212
DI 10.3390/antiox11061212
PG 18
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA 2J8FG
UT WOS:000815885100001
PM 35740109
OA gold, Green Published
HC Y
HP N
DA 2025-06-11
ER

PT S
AU Granato, D
   Barba, FJ
   Kovacevic, DB
   Lorenzo, JM
   Cruz, AG
   Putnik, P
AF Granato, Daniel
   Barba, Francisco J.
   Kovacevic, Danijela Bursac
   Lorenzo, Jose M.
   Cruz, Adriano G.
   Putnik, Predrag
BE Doyle, MP
   McClements, DJ
TI Functional Foods: Product Development, Technological Trends, Efficacy
   Testing, and Safety
SO ANNUAL REVIEW OF FOOD SCIENCE AND TECHNOLOGY, VOL 11
SE Annual Review of Food Science and Technology
LA English
DT Review; Book Chapter
DE nutraceuticals; probiotics; health-promoting foods; metabolic syndrome;
   oxidative stress; food innovation
ID INTERNATIONAL SCIENTIFIC ASSOCIATION; POTENTIAL HEALTH-BENEFITS;
   ALPHA-LINOLENIC ACID; CHAIN FATTY-ACIDS; ANTIOXIDANT ACTIVITY; IN-VITRO;
   OXIDATIVE STABILITY; PLANT STEROL; DOUBLE-BLIND; ANTIHYPERTENSIVE
   PEPTIDES
AB Functional foods is a very popular term in the social and scientific media; consequently, food producers have invested resources in the development of processed foods that may provide added functional benefits to consumers' well-being. Because of intrinsic regulation and end-of-use purposes in different countries, worldwide meanings and definitions of this term are still unclear. Hence, here we standardize this definition and propose a guideline to attest that some ingredients or foods truly deserve this special designation. Furthermore, focus is directed at the most recent studies and practical guidelines that can be used to develop and test the efficacy of potentially functional foods and ingredients. The most widespread functional ingredients, such as polyunsaturated fatty acids (PUFAs), probiotics/prebiotics/synbiotics, and antioxidants, and their technological means of delivery in food products are described. The review discusses the steps that food companies should take to ensure that their developed food product is truly functional.
C1 [Granato, Daniel] Nat Resources Inst Finland Luke, Innovat Food Syst, Prod Syst Unit, FI-0250 Espoo, Finland.
   [Barba, Francisco J.] Univ Valencia, Nutr & Food Sci Area, Prevent Med & Publ Hlth, Food Sci Toxicol & Forens Med Dept,Fac Pharm, E-46100 Valencia, Spain.
   [Kovacevic, Danijela Bursac; Putnik, Predrag] Univ Zagreb, Fac Food Technol & Biotechnol, Zagreb 10000, Croatia.
   [Lorenzo, Jose M.] Parque Tecnol Galicia, Ctr Tecnol Carne Galicia, San Cibrao Das Vinas 32900, Ourense, Spain.
   [Cruz, Adriano G.] Fed Inst Sci Educ & Technol Rio de Janeiro IFRJ, Dept Food, BR-20260100 Rio De Janeiro, Brazil.
C3 Natural Resources Institute Finland (Luke); University of Valencia;
   University of Zagreb
RP Granato, D (corresponding author), Nat Resources Inst Finland Luke, Innovat Food Syst, Prod Syst Unit, FI-0250 Espoo, Finland.
EM daniel.granato@luke.fi
RI CRUZ, ADRIANO/W-1485-2017; Bursać Kovačević, Danijela/I-2099-2019;
   Granato, Daniel/AAC-6151-2019; Lorenzo Rodriguez, Jose
   Manuel/K-6375-2014; , Predrag/B-6495-2016; Barba, Francisco
   Jose/L-6596-2014; Bursac Kovacevic, Danijela/C-6995-2016
OI Lorenzo Rodriguez, Jose Manuel/0000-0002-7725-9294; ,
   Predrag/0000-0003-0342-6114; Barba, Francisco Jose/0000-0002-5630-3989;
   Bursac Kovacevic, Danijela/0000-0002-6829-6472
FU Croatian Science Foundation [IP-2019-04-2105]
FX P. Putnik and D. Bursac Kovacevic wish to thank the Croatian Science
   Foundation for support through the funding of project number
   IP-2019-04-2105.
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NR 203
TC 402
Z9 426
U1 26
U2 451
PU ANNUAL REVIEWS
PI PALO ALTO
PA 4139 EL CAMINO WAY, PO BOX 10139, PALO ALTO, CA 94303-0897 USA
SN 1941-1413
EI 1941-1421
J9 ANNU REV FOOD SCI T
JI Annu. Rev. Food Sci. Technol.
PY 2020
VL 11
BP 93
EP 118
DI 10.1146/annurev-food-032519-051708
PG 26
WC Food Science & Technology
WE Book Citation Index – Science (BKCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA BO7EX
UT WOS:000523954500005
PM 31905019
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Morigi, M
   Perico, L
   Benigni, A
AF Morigi, Marina
   Perico, Luca
   Benigni, Ariela
TI Sirtuins in Renal Health and Disease
SO JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
LA English
DT Review
ID ACUTE KIDNEY INJURY; FATTY-ACID OXIDATION; CALORIE RESTRICTION;
   MITOCHONDRIAL DYNAMICS; SIRT3 DEACETYLATES; IMPROVES HEALTH; EMERGING
   ROLE; LIFE-SPAN; ACTIVATION; LONGEVITY
AB Sirtuins belong to an evolutionarily conserved family of NAD(+)-dependent deacetylases that share multiple cellular functions related to proliferation, DNA repair, mitochondrial energy homeostasis, and antioxidant activity. Mammalians express seven sirtuins (SIRT1-7) that are localized in different subcellular compartments. Changes in sirtuin expression are critical in several diseases, including metabolic syndrome, diabetes, cancer, and aging. In the kidney, the most widely studied sirtuin is SIRT1, which exerts cytoprotective effects by inhibiting cell apoptosis, inflammation, and fibrosis together with SIRT3, a crucial metabolic sensor that regulates ATP generation and mitochondrial adaptive response to stress. Here, we provide an overview of the biologic effects of sirtuins and the molecular targets thereof regulating renal physiology. This review also details progress made in understanding the effect of sirtuins in the pathophysiology of chronic and acute kidney diseases, highlighting the key role of SIRT1, SIRT3, and now SIRT6 as potential therapeutic targets. In this context, the current pharmacologic approaches to enhancing the activity of SIRT1 and SIRT3 will be discussed.
C1 [Morigi, Marina; Perico, Luca; Benigni, Ariela] IRCCS, Ctr Anna Maria Astori, Ist Ric Farmacol Mario Negri, Sci & Technol Pk Kilometro Rosso,Via Stezzano 87, I-24126 Bergamo, Italy.
C3 Istituto di Ricerche Farmacologiche Mario Negri IRCCS
RP Morigi, M (corresponding author), IRCCS, Ctr Anna Maria Astori, Ist Ric Farmacol Mario Negri, Sci & Technol Pk Kilometro Rosso,Via Stezzano 87, I-24126 Bergamo, Italy.
EM marina.morigi@marionegri.it
RI Morigi, Marina/ABH-3131-2020; Ariela, Benigni/ABH-3492-2020; Perico,
   Luca/ABH-3224-2020
OI Perico, Luca/0000-0003-3470-1721; Benigni, Ariela/0000-0002-4721-5485;
   Morigi, Marina/0000-0001-8029-7382
FU Fondazione Aiuti per la Ricerca sulle Malattie Rare, Bergamo, Italy
FX L.P. is the recipient of a fellowship from Fondazione Aiuti per la
   Ricerca sulle Malattie Rare, Bergamo, Italy.
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NR 128
TC 275
Z9 285
U1 3
U2 80
PU AMER SOC NEPHROLOGY
PI WASHINGTON
PA 1725 I ST, NW STE 510, WASHINGTON, DC 20006 USA
SN 1046-6673
EI 1533-3450
J9 J AM SOC NEPHROL
JI J. Am. Soc. Nephrol.
PD JUL
PY 2018
VL 29
IS 7
BP 1799
EP 1809
DI 10.1681/ASN.2017111218
PG 11
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA GM2GQ
UT WOS:000437901600006
PM 29712732
OA Green Published
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Onishi, S
   Kitazawa, H
   Meguro, S
   Tokimitsu, I
AF Onishi, Shintaro
   Kitazawa, Hidefumi
   Meguro, Shinichi
   Tokimitsu, Ichiro
TI Green tea extracts reduce leukocyte cell-Derived chemotaxin 2 and
   selenoprotein P levels in the livers of C57BL/6J mice fed a high-fat
   diet
SO BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
LA English
DT Article
DE Green tea extract; high-fat; leukocyte cell-derived chemotaxin 2;
   selenoprotein P
ID ENDOPLASMIC-RETICULUM STRESS; MUSCLE INSULIN-RESISTANCE; METABOLIC
   SYNDROME; PROTEIN-KINASE; EPIGALLOCATECHIN GALLATE; LINKS OBESITY;
   RISK-FACTORS; BODY-FAT; FETUIN-A; CATECHINS
AB Epidemiological studies suggest that green tea extracts (GTEs), including catechins such as epigallocatechin gallate and epicatechin gallate, have a beneficial effect on obesity, hyperglycemia, insulin resistance, endothelial dysfunction, and inflammation. Although several studies have shown that catechins directly modulate the cellular and molecular alterations in the liver tissue, the contributions of indirect mechanisms underlying these systemic effects of catechins remain unclear. In this study, we report that, in the C57BL/6J mouse liver, GTEs reduce high-fat diet-induced increases in the levels of hepatokines, liver-derived secretary proteins such as leukocyte cell-derived chemotaxin 2 and selenoprotein P production, which have been shown to induce systemic adverse effects, including several metabolic diseases. These findings suggest that the systemic effects of GTEs involve the regulation of hepatokine production as an indirect mechanism.
C1 [Onishi, Shintaro; Kitazawa, Hidefumi; Meguro, Shinichi] Kao Corp, Biol Sci Res, Ichikai, Tochigi, Japan.
   [Onishi, Shintaro; Kitazawa, Hidefumi; Meguro, Shinichi; Tokimitsu, Ichiro] Univ Shizuoka, Ind Acad Collaborat Res Lab, Shizuoka, Japan.
   [Onishi, Shintaro; Kitazawa, Hidefumi; Meguro, Shinichi; Tokimitsu, Ichiro] Univ Shizuoka, Kao Corp, Shizuoka, Japan.
   [Tokimitsu, Ichiro] Univ Human Arts & Sci, Dept Hlth & Food Sci, Iwatsuki Ku, Saitama, Saitama, Japan.
C3 KAO Corporation; University of Shizuoka; University of Shizuoka; KAO
   Corporation
RP Meguro, S (corresponding author), Kao Corp, Biol Sci Res, Ichikai, Tochigi, Japan.; Meguro, S (corresponding author), Univ Shizuoka, Ind Acad Collaborat Res Lab, Shizuoka, Japan.; Meguro, S (corresponding author), Univ Shizuoka, Kao Corp, Shizuoka, Japan.
EM meguro.shinichi@kao.com
OI Meguro, Shinichi/0000-0002-3072-2632
FU University of Shizuoka; Kao Corporation
FX This work was supported by industry-academia collaboration between the
   University of Shizuoka and Kao Corporation; Industry-academia
   collaboration between the University of Shizuoka and Kao Corporation.
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NR 43
TC 3
Z9 3
U1 0
U2 10
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0916-8451
EI 1347-6947
J9 BIOSCI BIOTECH BIOCH
JI Biosci. Biotechnol. Biochem.
PY 2018
VL 82
IS 9
BP 1568
EP 1575
DI 10.1080/09168451.2018.1480349
PG 8
WC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
   Chemistry, Applied; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
   Chemistry; Food Science & Technology
GA GS6XX
UT WOS:000443844500017
PM 29848194
OA Bronze
DA 2025-06-11
ER

PT J
AU Gläser, S
   Krüger, S
   Merkel, M
   Bramlage, P
   Herth, FJF
AF Glaeser, Sven
   Krueger, Stefan
   Merkel, Martin
   Bramlage, Peter
   Herth, Felix J. F.
TI Chronic Obstructive Pulmonary Disease and Diabetes Mellitus: A
   Systematic Review of the Literature
SO RESPIRATION
LA English
DT Review
DE Chronic obstructive pulmonary disease; Type-2 diabetes;
   Pathophysiological relationship; Inflammation
ID REDUCED LUNG-FUNCTION; C-REACTIVE PROTEIN; INSULIN-RESISTANCE; METABOLIC
   SYNDROME; INHALED CORTICOSTEROIDS; MYOCARDIAL-INFARCTION;
   ATHEROSCLEROSIS RISK; ACUTE EXACERBATIONS; CARDIOVASCULAR-DISEASE;
   STRESS HYPERGLYCEMIA
AB The objective of this systematic review was to discuss our current understanding of the complex relationship between chronic obstructive pulmonary disease (COPD) and type-2 diabetes mellitus (T2DM). We performed a systematic search of the literature related to both COPD and diabetes using PubMed. Relevant data connecting both diseases were compiled and discussed. Recent evidence suggests that diabetes can worsen the progression and prognosis of COPD; this may result from the direct effects of hyperglycemia on lung physiology, inflammation or susceptibility to bacterial infection. Conversely, it has also been suggested that COPD increases the risk of developing T2DM as a consequence of inflammatory processes and/or therapeutic side effects related to the use of high-dose corticosteroids. In conclusion, although there is evidence to support a connection between COPD and diabetes, additional research is needed to better understand these relationships and their possible implications. (C) 2015 S. Karger AG, Basel
C1 [Glaeser, Sven] Ernst Moritz Arndt Univ Greifswald, Dept Internal Med Cardiol Intens Care Pulm Med &, DE-17475 Greifswald, Germany.
   [Glaeser, Sven] Ernst Moritz Arndt Univ Greifswald, Sci Div Pneumol Res & Pneumol Epidemiol, DE-17475 Greifswald, Germany.
   [Krueger, Stefan] Florence Nightingale Hosp, Dept Pneumol Allergol Sleep & Respirat Med, Dusseldorf, Germany.
   [Merkel, Martin] Asklepios Clin St Georg, Dept Internal Med Gastroenterol Endocrinol Diabet, Hamburg, Germany.
   [Bramlage, Peter] Inst Pharmakol & Pravent Med, Mahlow, Germany.
   [Herth, Felix J. F.] Heidelberg Univ, Dept Pneumol & Crit Care Med, Thoraxklin, Heidelberg, Germany.
   [Herth, Felix J. F.] Translat Lung Res Ctr, Heidelberg, Germany.
C3 Universitat Greifswald; Universitat Greifswald; Asklepios Klinik St.
   Georg; Ruprecht Karls University Heidelberg
RP Gläser, S (corresponding author), Ernst Moritz Arndt Univ Greifswald, Dept Internal Med Cardiol Intens Care Pulm Med &, Fleischmannstr 42-44, DE-17475 Greifswald, Germany.
EM sven.glaeser@uni-greifswald.de
RI Herth, Felix/IZE-1794-2023
OI Merkel, Martin/0000-0002-2850-5110; Bramlage, Peter/0000-0003-4970-2110;
   Herth, Felix/0000-0002-7638-2506
FU Novartis Pharma GmbH, Nurnberg, Germany
FX All authors have received research grants and/or consultancy fees from
   Novartis Pharma GmbH, Nurnberg, Germany.
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NR 95
TC 107
Z9 117
U1 2
U2 24
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0025-7931
EI 1423-0356
J9 RESPIRATION
JI Respiration
PY 2015
VL 89
IS 3
BP 253
EP 264
DI 10.1159/000369863
PG 12
WC Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Respiratory System
GA CD8OP
UT WOS:000351355200014
PM 25677307
OA Bronze
DA 2025-06-11
ER

PT J
AU Svegliati-Baroni, G
   Candelaresi, C
   Saccomanno, S
   Ferretti, G
   Bachetti, T
   Marzioni, M
   De Minicis, S
   Nobili, L
   Salzano, R
   Omenetti, A
   Pacetti, D
   Sigmund, S
   Benedetti, A
   Casini, A
AF Svegliati-Baroni, Gianluca
   Candelaresi, Cinzia
   Saccomanno, Stefania
   Ferretti, Gianna
   Bachetti, Tiziana
   Marzioni, Marco
   De Minicis, Sarnuele
   Nobili, Liliana
   Salzano, Renata
   Omenetti, Alessia
   Pacetti, Deborah
   Sigmund, Soeren
   Benedetti, Antonio
   Casini, Alessandro
TI A model of insulin resistance and nonalcoholic steatohepatitis in rats
   -: Role of peroxisome proliferator-activated receptor-α and n-3
   polyunsaturated fatty acid treatment on liver injury
SO AMERICAN JOURNAL OF PATHOLOGY
LA English
DT Article
ID HEPATIC STEATOSIS; PPAR-ALPHA; METABOLIC SYNDROME; LIPID-METABOLISM;
   ANIMAL-TISSUES; IKK-BETA; KAPPA-B; DISEASE; MICE; ADIPONECTIN
AB Insulin resistance induces nonalcoholic fatty liver disease and nonalcoholic steatoliepatitis (NASH). We used a high-fat, high-calorie solid diet (HID) to create a model of insulin resistance and NASH in nongenetically modified rats and to study the relationship between visceral adipose tissue and liver. Obesity and insulin resistance occurred in HID rats, accompanied by a progressive increase in visceral adipose tissue tumor necrosis factor (TNF)-alpha mRNA and in circulating free fatty acids. HFD also decreased adiponectin mRNA and peroxisome proliferator-activated receptor (PPAR)-alpha expression in the visceral adipose tissue and the liver, respectively, and induced hepatic insulin resistance through TNF-alpha-mediated c-Jun N-terminal kinase (JNK)-dependent insulin receptor sub-strate-1(Ser307) phosphorylation. These modifications lead to hepatic steatosis accompanied by oxidative stress phenomena, necroinflammation, and hepatocyte apoptosis at 4 weeks and by pericentral fibrosis
C1 Univ Politecn Marche, Gastroenterol Clin, Dept Gastroenterol, I-60020 Ancona, Italy.
   Univ Politecn Marche, Inst Biochem, Ancona, Italy.
   Univ Politecn Marche, Dept Food Sci, Ancona, Italy.
   Nerviano Med Sci, Clin Pathol Lab, Preclin Dev, Nerviano, Italy.
   Univ Florence, Dept Clin Pathophysiol, Nutr Ctr, Florence, Italy.
   Univ Florence, Dept Clin Pathophysiol, GI Unit, Florence, Italy.
   Columbia Univ, Coll Phys & Surg, Med Ctr, Dept Med, New York, NY USA.
   Multidisciplinary Ctr Res Food Sci, Florence, Italy.
C3 Marche Polytechnic University; Marche Polytechnic University; Marche
   Polytechnic University; Nerviano Medical Sciences S.r.l; University of
   Florence; University of Florence; Columbia University
RP Svegliati-Baroni, G (corresponding author), Univ Politecn Marche, Gastroenterol Clin, Dept Gastroenterol, Via Tronto, I-60020 Ancona, Italy.
EM g.svegliati@univpm.it
RI Gabbi, Chiara/AAB-9677-2022; Marzioni, Marco/A-8153-2011; Omenetti,
   Alessia/K-5975-2016; Benedetti, Antonio/A-8189-2011
OI Marzioni, Marco/0000-0001-6014-6165; Omenetti,
   Alessia/0000-0002-8220-0385; Ferretti, Gianna/0000-0001-7879-7935;
   Benedetti, Antonio/0000-0003-0280-4574; svegliati-baroni,
   gianluca/0000-0003-4399-3359
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U1 0
U2 24
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0002-9440
EI 1525-2191
J9 AM J PATHOL
JI Am. J. Pathol.
PD SEP
PY 2006
VL 169
IS 3
BP 846
EP 860
DI 10.2353/ajpath.2006.050953
PG 15
WC Pathology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pathology
GA 077RY
UT WOS:000240048900013
PM 16936261
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Mehdi, SF
   Pusapati, S
   Anwar, MS
   Lohana, D
   Kumar, P
   Nandula, SA
   Nawaz, FK
   Tracey, K
   Yang, H
   LeRoith, D
   Brownstein, MJ
   Roth, J
AF Mehdi, Syed Faizan
   Pusapati, Suma
   Anwar, Muhammad Saad
   Lohana, Durga
   Kumar, Parkash
   Nandula, Savitri Aninditha
   Nawaz, Fatima Kausar
   Tracey, Kevin
   Yang, Huan
   LeRoith, Derek
   Brownstein, Michael J.
   Roth, Jesse
TI Glucagon-like peptide-1: a multi-faceted anti-inflammatory agent
SO FRONTIERS IN IMMUNOLOGY
LA English
DT Review
DE GLP-1; glucagon-like peptide-1; incretin; GLP-1 agonists; hormone;
   inflammation; anti-inflammation
ID BETA-CELL PROLIFERATION; TRANSGENIC MOUSE MODELS; FATTY LIVER-DISEASE;
   PARKINSONS-DISEASE; GLP-1 RECEPTOR; OXIDATIVE STRESS; WOUND FLUID;
   KAPPA-B; INFLAMMATION; EXPRESSION
AB Inflammation contributes to many chronic conditions. It is often associated with circulating pro-inflammatory cytokines and immune cells. GLP-1 levels correlate with disease severity. They are often elevated and can serve as markers of inflammation. Previous studies have shown that oxytocin, hCG, ghrelin, alpha-MSH and ACTH have receptor-mediated anti-inflammatory properties that can rescue cells from damage and death. These peptides have been studied well in the past century. In contrast, GLP-1 and its anti-inflammatory properties have been recognized only recently. GLP-1 has been proven to be a useful adjuvant therapy in type-2 diabetes mellitus, metabolic syndrome, and hyperglycemia. It also lowers HbA1C and protects cells of the cardiovascular and nervous systems by reducing inflammation and apoptosis. In this review we have explored the link between GLP-1, inflammation, and sepsis.
C1 [Mehdi, Syed Faizan; Pusapati, Suma; Anwar, Muhammad Saad; Lohana, Durga; Kumar, Parkash; Nandula, Savitri Aninditha; Nawaz, Fatima Kausar; Tracey, Kevin; Yang, Huan; Roth, Jesse] Feinstein Inst Med Res, Northwell Hlth, Manhasset, NY 11030 USA.
   [LeRoith, Derek] Icahn Sch Med Mt Sinai, Div Endocrinol Diabet & Bone Dis, New York, NY USA.
   [Brownstein, Michael J.] Azevan Pharmaceut, Bethlehem, PA USA.
C3 Northwell Health; Icahn School of Medicine at Mount Sinai
RP Roth, J (corresponding author), Feinstein Inst Med Res, Northwell Hlth, Manhasset, NY 11030 USA.
EM jroth2@northwell.edu
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NR 211
TC 91
Z9 94
U1 21
U2 59
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-3224
J9 FRONT IMMUNOL
JI Front. Immunol.
PD MAY 17
PY 2023
VL 14
AR 1148209
DI 10.3389/fimmu.2023.1148209
PG 20
WC Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology
GA H7HT2
UT WOS:000997637300001
PM 37266425
OA Green Published, gold
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Liu, JY
   Wu, AD
   Cai, JJ
   She, ZG
   Li, HL
AF Liu, Jiayi
   Wu, Anding
   Cai, Jingjing
   She, Zhi-Gang
   Li, Hongliang
TI The contribution of the gut-liver axis to the immune signaling pathway
   of NAFLD
SO FRONTIERS IN IMMUNOLOGY
LA English
DT Review
DE NAFLD (nonalcoholic fatty liver disease); intestinal flora; gut-liver
   axis; Inflammation; lipid metabolism; insulin resistance
ID CHAIN AMINO-ACIDS; INTESTINAL BACTERIAL OVERGROWTH; DIET-INDUCED
   STEATOHEPATITIS; LOW-GRADE INFLAMMATION; NONALCOHOLIC STEATOHEPATITIS;
   BILE-ACID; DOUBLE-BLIND; FATTY-ACIDS; MICROBIOTA DYSBIOSIS; HEPATIC
   STEATOSIS
AB Nonalcoholic fatty liver disease (NAFLD) is the liver manifestation of metabolic syndrome and is the most common chronic liver disease in the world. The pathogenesis of NAFLD has not been fully clarified; it involves metabolic disturbances, inflammation, oxidative stress, and various forms of cell death. The "intestinal-liver axis" theory, developed in recent years, holds that there is a certain relationship between liver disease and the intestinal tract, and changes in intestinal flora are closely involved in the development of NAFLD. Many studies have found that the intestinal flora regulates the pathogenesis of NAFLD by affecting energy metabolism, inducing endotoxemia, producing endogenous ethanol, and regulating bile acid and choline metabolism. In this review, we highlighted the updated discoveries in intestinal flora dysregulation and their link to the pathogenesis mechanism of NAFLD and summarized potential treatments of NAFLD related to the gut microbiome.
C1 [Liu, Jiayi; She, Zhi-Gang; Li, Hongliang] Wuhan Univ, Dept Cardiol, Renmin Hosp, Wuhan, Peoples R China.
   [Liu, Jiayi; She, Zhi-Gang; Li, Hongliang] Wuhan Univ, Inst Model Anim, Wuhan, Peoples R China.
   [Wu, Anding] Huanggang Cent Hosp, Dept Gen Surg, Huanggang, Peoples R China.
   [Wu, Anding] Huanggang Inst Translat Med, Huanggang, Peoples R China.
   [Cai, Jingjing] Cent South Univ, Xiangya Hosp 3, Dept Cardiol, Changsha, Peoples R China.
   [Li, Hongliang] Wuhan Univ, Med Sci Res Ctr, Zhongnan Hosp, Wuhan, Peoples R China.
   [Li, Hongliang] Wuhan Univ, Sch Basic Med Sci, Wuhan, Peoples R China.
C3 Wuhan University; Wuhan University; Central South University; Wuhan
   University; Wuhan University
RP She, ZG; Li, HL (corresponding author), Wuhan Univ, Dept Cardiol, Renmin Hosp, Wuhan, Peoples R China.; She, ZG; Li, HL (corresponding author), Wuhan Univ, Inst Model Anim, Wuhan, Peoples R China.; Li, HL (corresponding author), Wuhan Univ, Med Sci Res Ctr, Zhongnan Hosp, Wuhan, Peoples R China.; Li, HL (corresponding author), Wuhan Univ, Sch Basic Med Sci, Wuhan, Peoples R China.
EM zgshe@whu.edu.cn; lihl@whu.edu.cn
RI Cai, Jingjing/JXN-8391-2024; jiayi, liu/JMQ-9878-2023; She,
   Zhi-Gang/AFP-9194-2022
OI She, Zhi-Gang/0000-0001-9402-4166
FU National Science Foundation of China; Hubei Province Innovation Platform
   Construction Project;  [81770053];  [81970364];  [81870171]; 
   [82170436];  [20204201117303072238]
FX Funding This work was supported by the National Science Foundation of
   China (81770053, 81970364 to Z-GS, 81870171, 82170436 to JC) and grants
   from the Hubei Province Innovation Platform Construction Project
   (20204201117303072238 to HL)
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NR 173
TC 26
Z9 27
U1 4
U2 54
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-3224
J9 FRONT IMMUNOL
JI Front. Immunol.
PD AUG 31
PY 2022
VL 13
AR 968799
DI 10.3389/fimmu.2022.968799
PG 15
WC Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology
GA 6P6SK
UT WOS:000891058500001
PM 36119048
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Paganoni, R
   Lechel, A
   Spasic, MV
AF Paganoni, Rossana
   Lechel, Andre
   Vujic Spasic, Maja
TI Iron at the Interface of Hepatocellular Carcinoma
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE iron; hepcidin; ROS; hepatocellular carcinoma; hemochromatosis; HFE;
   NAFLD; metabolic syndrome
ID FATTY LIVER-DISEASE; POPULATION-ATTRIBUTABLE FRACTIONS; GLOBAL CANCER
   STATISTICS; CHRONIC HEPATITIS-C; HFE GENE; NONALCOHOLIC STEATOHEPATITIS;
   DIABETES-MELLITUS; HEREDITARY HEMOCHROMATOSIS; TRANSFERRIN RECEPTOR;
   OXIDATIVE STRESS
AB Cancer incidence and mortality are rapidly growing, with liver cancer being the sixth most diagnosed cancer worldwide and the third leading cause of cancer death in 2020. A number of risk factors have been identified that trigger the progression to hepatocellular carcinoma. In this review, we focus on iron as a potential risk factor for liver carcinogenesis. Molecules involved in the regulation of iron metabolism are often upregulated in cancer cells, in order to provide a supply of this essential trace element for all stages of tumor development, survival, proliferation, and metastasis. Thus, cellular and systemic iron levels must be tightly regulated to prevent or delay liver cancer progression. Disorders associated with dysregulated iron metabolism are characterized with increased susceptibility to hepatocellular carcinoma. This review discusses the association of iron with metabolic disorders such as hereditary hemochromatosis, non-alcoholic fatty liver disease, obesity, and type 2 diabetes, in the background of hepatocellular carcinoma.
C1 [Paganoni, Rossana; Vujic Spasic, Maja] Ulm Univ, Inst Comparat Mol Endocrinol, D-89081 Ulm, Germany.
   [Lechel, Andre] Univ Hosp Ulm, Dept Internal Med 1, D-89081 Ulm, Germany.
C3 Ulm University; Ulm University
RP Spasic, MV (corresponding author), Ulm Univ, Inst Comparat Mol Endocrinol, D-89081 Ulm, Germany.
EM rossana.paganoni@uni-ulm.de; andre.lechel@uni-ulm.de;
   maja.vujic@uni-ulm.de
RI Lechel, André/AAQ-2041-2021
OI Lechel, Andre/0000-0003-0221-6959
FU DFG [VU 75/4-1]
FX Funded by the DFG, grant number VU 75/4-1 (to M.V.S.).
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NR 170
TC 36
Z9 36
U1 1
U2 14
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD APR
PY 2021
VL 22
IS 8
AR 4097
DI 10.3390/ijms22084097
PG 15
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA RT3OI
UT WOS:000644371100001
PM 33921027
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Warner, J
   Hardesty, J
   Zirnheld, K
   McClain, C
   Warner, D
   Kirpich, I
AF Warner, Jeffrey
   Hardesty, Josiah
   Zirnheld, Kara
   McClain, Craig
   Warner, Dennis
   Kirpich, Irina
TI Soluble Epoxide Hydrolase Inhibition in Liver Diseases: A Review of
   Current Research and Knowledge Gaps
SO BIOLOGY-BASEL
LA English
DT Review
DE non-alcoholic liver disease; metabolic syndrome; fibrosis; portal
   hypertension; soluble epoxide hydrolase; eicosanoids
ID ENDOPLASMIC-RETICULUM STRESS; HIGH-FAT DIET; THERAPEUTIC TARGET;
   PPAR-GAMMA; EPOXYEICOSATRIENOIC ACIDS; ENDOTHELIAL DYSFUNCTION;
   CARBON-TETRACHLORIDE; HEPATIC STEATOSIS; NITRIC-OXIDE; FIBROSIS
AB Emerging evidence suggests that soluble epoxide hydrolase (sEH) inhibition is a valuable therapeutic strategy for the treatment of numerous diseases, including those of the liver. sEH rapidly degrades cytochrome P450-produced epoxygenated lipids (epoxy-fatty acids), which are synthesized from omega-3 and omega-6 polyunsaturated fatty acids, that generally exert beneficial effects on several cellular processes. sEH hydrolysis of epoxy-fatty acids produces dihydroxy-fatty acids which are typically less biologically active than their parent epoxide. Efforts to develop sEH inhibitors have made available numerous compounds that show therapeutic efficacy and a wide margin of safety in a variety of different diseases, including non-alcoholic fatty liver disease, liver fibrosis, portal hypertension, and others. This review summarizes research efforts which characterize the applications, underlying effects, and molecular mechanisms of sEH inhibitors in these liver diseases and identifies gaps in knowledge for future research.
C1 [Warner, Jeffrey; Hardesty, Josiah; Zirnheld, Kara; McClain, Craig; Warner, Dennis; Kirpich, Irina] Univ Louisville, Dept Med, Div Gastroenterol Hepatol & Nutr, Louisville, KY 40292 USA.
   [Warner, Jeffrey; Hardesty, Josiah; McClain, Craig; Kirpich, Irina] Univ Louisville, Sch Med, Dept Pharmacol & Toxicol, Louisville, KY 40202 USA.
   [McClain, Craig; Kirpich, Irina] Univ Louisville, Sch Med, Dept Med, Alcohol Res Ctr, Louisville, KY 40202 USA.
   [McClain, Craig; Kirpich, Irina] Univ Louisville, Sch Med, Hepatobiol & Toxicol Ctr, Louisville, KY 40202 USA.
   [McClain, Craig] Robley Rex Vet Med Ctr, Louisville, KY 40206 USA.
C3 University of Louisville; University of Louisville; University of
   Louisville; University of Louisville
RP Kirpich, I (corresponding author), Univ Louisville, Dept Med, Div Gastroenterol Hepatol & Nutr, Louisville, KY 40292 USA.; Kirpich, I (corresponding author), Univ Louisville, Sch Med, Dept Pharmacol & Toxicol, Louisville, KY 40202 USA.; Kirpich, I (corresponding author), Univ Louisville, Sch Med, Dept Med, Alcohol Res Ctr, Louisville, KY 40202 USA.; Kirpich, I (corresponding author), Univ Louisville, Sch Med, Hepatobiol & Toxicol Ctr, Louisville, KY 40202 USA.
EM jbwarn01@louisville.edu; josiah.hardesty@louisville.edu;
   kara.zirnheld@louisville.edu; craig.mcclain@louisville.edu;
   dennis.warner@louisville.edu; irina.kirpich@louisville.edu
OI McClain, Craig/0000-0002-7219-8939; Warner, Jeffrey/0000-0003-2022-7854
FU National Institutes of Health [R01 AA024102-01A1, T32ES011564,
   F32AA027950-01A1, U01AA026934, 1U01AA026926-01, 1U01AA026980-01,
   R01AA023681]; Department of Veterans A ffairs [I01BX002996];
   Institutional Development Award (IDeA) from the National Institute of
   General Medical Sciences of the National Institutes of Health
   [P20GM113226]; National Institute on Alcohol Abuse and Alcoholism of the
   National Institutes of Health [P50AA024337]
FX This research was funded by National Institutes of Health grants R01
   AA024102-01A1 (IAK), T32ES011564 (JEH), F32AA027950-01A1 (JEH),
   U01AA026934 (CJM), 1U01AA026926-01 (CJM), 1U01AA026980-01 (CJM), and
   R01AA023681 (CJM), and the Department of Veterans A ffairs I01BX002996
   (CJM). This work was also supported by an Institutional Development
   Award (IDeA) from the National Institute of General Medical Sciences of
   the National Institutes of Health under grant number P20GM113226 (CJM),
   and the National Institute on Alcohol Abuse and Alcoholism of the
   National Institutes of Health under Award Number P50AA024337 (CJM).The
   content is solely the responsibility of the authors and does not
   necessarily represent the official views of the National Institutes of
   Health.
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NR 100
TC 18
Z9 19
U1 0
U2 10
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2079-7737
J9 BIOLOGY-BASEL
JI Biology-Basel
PD JUN
PY 2020
VL 9
IS 6
AR 124
DI 10.3390/biology9060124
PG 18
WC Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics
GA MN9WI
UT WOS:000551189400005
PM 32545637
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Batista, AG
   da Silva-Maia, JK
   Mendonça, MCP
   Soares, ES
   Lima, GC
   Bogusz, S
   da Cruz-Höfling, MA
   Marostica, MR
AF Batista, Angela Giovana
   da Silva-Maia, Juliana Kelly
   Mendonca, Monique Culturato P.
   Soares, Edilene Siqueira
   Lima, Glaucia Carielo
   Bogusz Junior, Stanislau
   da Cruz-Hofling, Maria Alice
   Marostica Junior, Mario Roberto
TI Jaboticaba berry peel intake increases short chain fatty acids
   production and prevent hepatic steatosis in mice fed high-fat diet
SO JOURNAL OF FUNCTIONAL FOODS
LA English
DT Article
DE Jabuticaba; Myrtacea; Obesity; Metabolic syndrome; Polyphenols
ID INSULIN-RESISTANCE; INDUCED OBESITY; GUT MICROBIOTA; OXIDATIVE STRESS;
   LIPID PROFILE; RATS; CHOLESTEROL; INFLAMMATION; ASSOCIATION; POLYPHENOLS
AB In this study, a preventive model was proposed to check whether the intake of Myrciaria jaboticaba berry peel (MJP) could avoid harmful effects caused by a high-fat diet. The intake of the high-fat diet supplemented with MJP (HM mice) down-regulated pro-inflammatory cytokines in adipose tissue and prevented adipose tissue growth and accumulation. In addition, the intake of the high-fat diet supplemented with MJP prevented weight gain, increased the excretion of triglycerides, reduced hepatic steatosis area and stimulated the production of short chain fatty acids (SCFA) by the large intestinal microbiota. Furthermore, hepatic mRNA PPAR-alpha level was lowered in non-fasted animals of the HM mice, indicating lower oxidation of both fatty acids and lipotoxic metabolites by the liver. In conclusion, MJP intake induces higher production of the gut SCFA, compounds known to counteract obesity markers, as shown by the lowering of adipose tissue inflammation, weight gain, dyslipidemia and hepatic steatosis.
C1 [Batista, Angela Giovana; da Silva-Maia, Juliana Kelly; Lima, Glaucia Carielo; Marostica Junior, Mario Roberto] Univ Campinas Unicamp, Dept Food & Nutr, Fac Food Engn, Campinas, SP, Brazil.
   [Batista, Angela Giovana] Fed Univ Santa Maria UFSM, Dept Food & Nutr, Palmeira Das Missoes, RS, Brazil.
   [Mendonca, Monique Culturato P.; Soares, Edilene Siqueira; da Cruz-Hofling, Maria Alice] Univ Campinas Unicamp, Dept Biochem & Tissue Biol, Inst Biol, Campinas, SP, Brazil.
   [Bogusz Junior, Stanislau] Univ Sao Paulo, Sao Carlos Inst Chem IQSC, Sao Carlos, SP, Brazil.
C3 Universidade Estadual de Campinas; Universidade Estadual de Campinas;
   Universidade de Sao Paulo; Universidade de Sao Paulo
RP Marostica, MR (corresponding author), Dept Alimentos & Nutr, Rua Monteiro Lobato 80,Cidade Univ, BR-13083862 Campinas, SP, Brazil.
EM mario@fea.unicamp.br
RI SOARES, EDILENE/AAF-1216-2021; Mendonça, Monique/O-6836-2015; Bogusz,
   Stanislau/M-5320-2013; Batista, Angela/H-8728-2012; Marostica Junior,
   Mario Roberto/P-5936-2018
OI Siqueira Soares, Edilene/0000-0002-8838-2570; Batista,
   Angela/0000-0002-1650-6589; Mendonca, Monique/0000-0002-8129-2150;
   Bogusz Junior, Stanislau/0000-0002-4382-5745; Marostica Junior, Mario
   Roberto/0000-0001-8877-3160
FU CNPq [301108/2016-1, 403328/2016-0, 2015/50333-1, 305099/2011-6]; FAPESP
   [301108/2016-1, 403328/2016-0, 2015/50333-1, 305099/2011-6]; CAPES;
   Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
   [15/50333-1] Funding Source: FAPESP
FX This study was supported by the CNPq and FAPESP (MRMJ for CNPq
   #301108/2016-1 and 403328/2016-0, FAPESP #2015/50333-1 and MACH for CNPq
   #305099/2011-6) and CAPES. PRP-PRGP/UNICAMP provided laboratory
   infrastructure renewal.
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NR 34
TC 32
Z9 33
U1 1
U2 35
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1756-4646
J9 J FUNCT FOODS
JI J. Funct. Food.
PD SEP
PY 2018
VL 48
BP 266
EP 274
DI 10.1016/j.jff.2018.07.020
PG 9
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA GX2TS
UT WOS:000447573600029
DA 2025-06-11
ER

PT J
AU Molinar-Toribio, E
   Pérez-Jiménez, J
   Ramos-Romero, S
   Gómez, L
   Taltavull, N
   Rosa Nogués, M
   Adeva, A
   Jáuregui, O
   Joglar, J
   Clapés, P
   Lluís Torres, J
AF Molinar-Toribio, Eunice
   Perez-Jimenez, Jara
   Ramos-Romero, Sara
   Gomez, Livia
   Taltavull, Nuria
   Rosa Nogues, Maria
   Adeva, Alberto
   Jauregui, Olga
   Joglar, Jesus
   Clapes, Pere
   Lluis Torres, Josep
TI D-Fagomine attenuates metabolic alterations induced by a
   high-energy-dense diet in rats
SO FOOD & FUNCTION
LA English
DT Article
ID HIGH-FAT; INSULIN-RESISTANCE; OXIDATIVE STRESS; INDUCED OBESITY; GUT
   MICROBIOTA; GHRELIN; SUCROSE; LEPTIN; FOOD; F-2-ISOPROSTANES
AB D-Fagomine is a natural iminosugar that counteracts the short-term effects of a high-energy-dense diet on body weight, fasting blood glucose levels and the proportion of gut Enterobacteriales. This suggests that supplementation with D-fagomine for longer periods may delay the onset of other factors related to metabolic syndrome. Here we evaluate the effects of D-fagomine dietary supplementation on relevant metabolic hormones and lipid peroxidation. Adult Sprague-Dawley rats were fed a high-fat high-sucrose diet supplemented or not with D-fagomine (0.065% w/w) for 9 weeks. Weight gain, plasma triglycerides, glucose, insulin, glucagon, ghrelin, leptin, and urine F2-isoprostanes were evaluated. D-Fagomine attenuated the changes induced by the high-energy-dense diet in triglycerides and all the hormones tested. These results suggest that D-fagomine may help to avert the complications associated with unhealthy eating by counteracting the effects of high-energy-dense diets during the early stages of the development of metabolic disorders.
C1 [Molinar-Toribio, Eunice; Perez-Jimenez, Jara; Ramos-Romero, Sara; Joglar, Jesus; Clapes, Pere; Lluis Torres, Josep] CSIC, Inst Adv Chem Catalonia IQAC, Barcelona, Spain.
   [Ramos-Romero, Sara] Biomed Res Networking Ctr Bioengn Biomat & Nanome, Zaragoza, Spain.
   [Gomez, Livia] Bioglane SLNE, Barcelona, Spain.
   [Taltavull, Nuria; Rosa Nogues, Maria] Univ Rovira & Virgili, Fac Med & Hlth Sci, Unit Pharmacol, E-43201 Reus, Spain.
   [Adeva, Alberto; Jauregui, Olga] Univ Barcelona CCiT UB, Ctr Sci, Barcelona, Spain.
   [Adeva, Alberto; Jauregui, Olga] Univ Barcelona CCiT UB, Ctr Technol, Barcelona, Spain.
C3 Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Centro de
   Investigacion y Desarrollo Pascual Vila (CID-CSIC); CSIC - Instituto de
   Quimica Avanzada de Cataluna (IQAC); CIBER - Centro de Investigacion
   Biomedica en Red; CIBERBBN; Universitat Rovira i Virgili; University of
   Barcelona; University of Barcelona
RP Molinar-Toribio, E (corresponding author), CSIC, Inst Adv Chem Catalonia IQAC, Barcelona, Spain.
EM sara.ramos@iqac.csic.es
RI Clapes, Pere/D-8938-2015; Perez-Jimenez, Jara/B-3989-2009; Ramos-Romero,
   Sara/AAH-6209-2020; Joglar, Jesus/F-5188-2015; Torres,
   Josep/N-7256-2013; Ramos-Romero, Sara/K-8301-2017
OI Joglar, Jesus/0000-0002-3391-1682; Torres, Josep/0000-0002-5072-8265;
   Taltavull, Nuria/0000-0002-3340-2650; Gomez, Livia/0000-0002-0135-2978;
   Molinar-Toribio, Eunice/0000-0001-8870-6849; Perez-Jimenez,
   Jara/0000-0002-2811-4558; Adeva, Alberto/0000-0003-3749-3796;
   Ramos-Romero, Sara/0000-0002-9293-4454; Jauregui,
   Olga/0000-0002-5834-3829
FU Spanish Ministry of Science and Innovation [CDTI-NEOTEC 20080474,
   IPT-2011-0828-900000, AGL2009-12374-C03-03/ALI, AGL2013-49079-C2-1,
   2-R]; Catalan regional government (Generalitat de Catalunya)
   [2014SGR1017]; Panamanian government; Bioglane SLNE
FX Support is appreciated from the Spanish Ministry of Science and
   Innovation (grants CDTI-NEOTEC 20080474, IPT-2011-0828-900000,
   AGL2009-12374-C03-03/ALI and AGL2013-49079-C2-1,2-R); the Catalan
   regional government (Generalitat de Catalunya, grant 2014SGR1017 and a
   pre-doctoral fellowship to LG); and the Panamanian government (grant
   SENACYT/IFARHU and a pre-doctoral fellowship to EM-T). This work was
   partially funded by Bioglane SLNE. The authors thank Dr Isidre Casals of
   the Scientific and Technological Centers of the Universitat de Barcelona
   for technical assistance and advice. Language revision by Christopher
   Evans is appreciated.
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NR 35
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Z9 20
U1 0
U2 22
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PY 2015
VL 6
IS 8
BP 2614
EP 2619
DI 10.1039/c5fo00591d
PG 6
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA CO4KD
UT WOS:000359128700019
PM 26130374
DA 2025-06-11
ER

PT J
AU Prasath, GS
   Subramanian, SP
AF Prasath, Gopalan Sriram
   Subramanian, Sorimuthu Pillai
TI Antihyperlipidemic Effect of Fisetin, a Bioflavonoid of Strawberries,
   Studied in Streptozotocin-Induced Diabetic Rats
SO JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
LA English
DT Article
DE Fisetin; Streptozotocin; Diabetes; Antihyperlipidemic Property
ID SPRAGUE-DAWLEY RATS; FREE FATTY-ACIDS; DIETARY-FAT; METABOLIC SYNDROME;
   GLUCOSE-TOLERANCE; OXIDATIVE STRESS; HYPERGLYCEMIA; TISSUES; WOMEN;
   SERUM
AB Chronic hyperglycemia in diabetes is associated with profound changes in lipid and lipoprotein metabolism, with resultant alterations in particle distribution within lipoprotein classes. In the present study, an attempt has been made to explore the antihyperlipidemic effect of fisetin in streptozotocin-induced experimental diabetes in rats. Upon fisetin treatment to diabetic rats, the levels of blood glucose were significantly reduced with an improvement in plasma insulin. The increased levels of lipid contents in serum, hepatic, and renal tissues observed in diabetic rats were normalized upon fisetin administration. Also, the decreased levels of high-density lipoprotein cholesterol, and increased levels of low-density lipoprotein (LDL) and very LDL (VLDL) cholesterol in serum of diabetic rats were normalized. Oil Red O staining established a large number of intracellular lipid droplets accumulation in the diabetic rats. Fisetin treatment exacerbated the degree of lipid accumulation. The results of the present study exemplify the antihyperlipidemic property of the fisetin.
C1 [Prasath, Gopalan Sriram; Subramanian, Sorimuthu Pillai] Univ Madras, Dept Biochem, Madras 600025, Tamil Nadu, India.
C3 University of Madras
RP Subramanian, SP (corresponding author), Univ Madras, Dept Biochem, Guindy Campus, Madras 600025, Tamil Nadu, India.
EM subbus2020@yahoo.co.in
RI GOPALAN, SRIRAM PRASATH/HHY-8253-2022
OI GOPALAN, SRIRAM PRASATH/0000-0001-7351-1504
FU University Grant Commission (UGC), New Delhi, India
FX The Research Fellowship of the University Grant Commission (UGC), New
   Delhi, India, to the Mr. G. Sriram Prasath in the form of UGC-BSR is
   gratefully acknowledged. The authors declare that they have no conflict
   of interest.
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NR 46
TC 40
Z9 40
U1 3
U2 14
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1095-6670
EI 1099-0461
J9 J BIOCHEM MOL TOXIC
JI J. Biochem. Mol. Toxicol.
PD OCT
PY 2014
VL 28
IS 10
BP 442
EP 449
DI 10.1002/jbt.21583
PG 8
WC Biochemistry & Molecular Biology; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Toxicology
GA AQ4UA
UT WOS:000342794000002
PM 24939606
DA 2025-06-11
ER

PT J
AU Simone, BA
   Champ, CE
   Rosenberg, AL
   Berger, AC
   Monti, DA
   Dicker, AP
   Simone, NL
AF Simone, Brittany A.
   Champ, Colin E.
   Rosenberg, Anne L.
   Berger, Adam C.
   Monti, Daniel A.
   Dicker, Adam P.
   Simone, Nicole L.
TI Selectively starving cancer cells through dietary manipulation: methods
   and clinical implications
SO FUTURE ONCOLOGY
LA English
DT Review
DE caloric restriction; cancer; diet; intermittent fasting; ketosis
ID CHRONIC CALORIC RESTRICTION; LOW-CARBOHYDRATE DIET; ENERGY RESTRICTION;
   MEDITERRANEAN DIET; OXIDATIVE STRESS; LONG-TERM; PROSTATE-CANCER;
   MAMMARY-TUMORS; KETOGENIC DIET; INSULIN SENSITIVITY
AB As the link between obesity and metabolic syndrome and cancer becomes clearer, the need to determine the optimal way to incorporate dietary manipulation in the treatment of cancer patients becomes increasingly important. Metabolic-based therapies, such as caloric restriction, intermittent fasting and a ketogenic diet, have the ability to decrease the incidence of spontaneous tumors and slow the growth of primary tumors, and may have an effect on distant metastases in animal models. Despite the abundance of preclinical data demonstrating the benefit of dietary modification for cancer, to date there are few clinical trials targeting diet as an intervention for cancer patients. We hypothesize that this may be due, in part, to the fact that several different types of diet modification exist with no clear recommendations regarding the optimal method. This article will delineate three commonly used methods of dietary manipulation to assess the potential of each as a regimen for cancer therapy.
C1 [Simone, Brittany A.; Champ, Colin E.; Dicker, Adam P.; Simone, Nicole L.] Thomas Jefferson Univ, Dept Radiat Oncol, Kimmel Canc Ctr, Philadelphia, PA 19107 USA.
   [Simone, Brittany A.; Champ, Colin E.; Rosenberg, Anne L.; Berger, Adam C.; Dicker, Adam P.; Simone, Nicole L.] Thomas Jefferson Univ, Jefferson Med Coll, Philadelphia, PA 19107 USA.
   [Rosenberg, Anne L.; Berger, Adam C.] Thomas Jefferson Univ, Dept Surg, Kimmel Canc Ctr, Philadelphia, PA 19107 USA.
   [Monti, Daniel A.] Thomas Jefferson Univ Hosp, Myrna Brind Ctr Integrat Med, Philadelphia, PA 19107 USA.
C3 Thomas Jefferson University; Thomas Jefferson University; Thomas
   Jefferson University; Thomas Jefferson University
RP Simone, NL (corresponding author), Thomas Jefferson Univ, Dept Radiat Oncol, Kimmel Canc Ctr, Philadelphia, PA 19107 USA.
EM nicole.simone@jeffersonhospital.org
RI Monti, Daniela/G-9556-2012; Champ, Colin/AAA-6842-2019
OI Champ, Colin/0000-0002-1879-7463; Dicker, Adam/0000-0003-0733-3337;
   Simone, Brittany/0000-0001-9585-7370; Simone, Nicole/0000-0002-7662-7470
FU Kimmel Cancer Center's National Cancer Institute Cancer Center Support
   Grant [P30 CA56036]
FX This article was supported in part by the Kimmel Cancer Center's
   National Cancer Institute Cancer Center Support Grant P30 CA56036. The
   authors have no other relevant affiliations or financial involvement
   with any organization or entity with a financial interest in or
   financial conflict with the subject matter or materials discussed in the
   manuscript apart from those disclosed.
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NR 120
TC 47
Z9 60
U1 0
U2 42
PU FUTURE MEDICINE LTD
PI LONDON
PA UNITEC HOUSE, 3RD FLOOR, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON, N3
   1QB, ENGLAND
SN 1479-6694
EI 1744-8301
J9 FUTURE ONCOL
JI Future Oncol.
PD JUL
PY 2013
VL 9
IS 7
BP 959
EP 976
DI 10.2217/FON.13.31
PG 18
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA 292XA
UT WOS:000329934800012
PM 23837760
DA 2025-06-11
ER

PT J
AU Ladopoulou, E
   Matralis, AN
   Kourounakis, AP
AF Ladopoulou, Eleni
   Matralis, Alexios N.
   Kourounakis, Angeliki P.
TI New Multifunctional
   Di-tert-butylphenoloctahydro(pyrido/benz)oxazine Derivatives with
   Antioxidant, Antihyperlipidemic, and Antidiabetic Action
SO JOURNAL OF MEDICINAL CHEMISTRY
LA English
DT Article
ID SQUALENE SYNTHASE INHIBITORS; HIGH-FAT DIET; LIPID-PEROXIDATION; DOSE
   STREPTOZOTOCIN; SUCCINOBUCOL; ACTIVATION; MECHANISMS; LOVASTATIN;
   PROTECTS; LIGANDS
AB Oxidative stress, inflammation, and hyperlipidemia are common factors involved in the pathophysiology, a atherosclerosis and type 2 diabetes. We have previously developed multifunctional antidyslipidemic derivatives with antioxidant and antiatherogenic properties. We now:report,the design, synthesis, and evaluation of two such novel derivatives that incorporate a structural moiety of the antidiabetic agent succinobucol. The new compounds a much improved in vitro antioxidant and squalene synthase inhibitory activity (at lower micromolar concentrations) as well as a significant antihyperlipidemic effect, reducing plasma total cholesterol, triglycerides, and MDA by 65-90%. Compound 2 also indicated a good anti-inflammatory activity, decreasing edema by 44%, while it was further evaluated for its antidiabetic activity using a type 2 diabetes experimental mouse model. After 7 weeks of administration, it produced a significant antihyperglycemic and antihyperlipidemic activity. In conclusion, rational drug design le to a compound combining improved antioxidant antidyslipidemic and antidiabetic action that may serve as a potential therapeutic. strategy in metabolic syndrome disorders.
C1 [Ladopoulou, Eleni; Matralis, Alexios N.; Kourounakis, Angeliki P.] Univ Athens, Sch Pharm, Dept Med Chem, GR-15771 Athens, Greece.
C3 National & Kapodistrian University of Athens
RP Kourounakis, AP (corresponding author), Univ Athens, Sch Pharm, Dept Med Chem, GR-15771 Athens, Greece.
EM angeliki@pharm.uoa.gr
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NR 42
TC 21
Z9 21
U1 0
U2 29
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0022-2623
EI 1520-4804
J9 J MED CHEM
JI J. Med. Chem.
PD APR 25
PY 2013
VL 56
IS 8
BP 3330
EP 3338
DI 10.1021/jm400101e
PG 9
WC Chemistry, Medicinal
WE Science Citation Index Expanded (SCI-EXPANDED); Index Chemicus (IC)
SC Pharmacology & Pharmacy
GA 134LG
UT WOS:000318211100017
PM 23581491
DA 2025-06-11
ER

PT J
AU Won, JU
   Hong, OS
   Hwang, WJ
AF Won, Jong Uk
   Hong, Oi Saeng
   Hwang, Won Ju
TI Actual Cardiovascular Disease Risk and Related Factors A Cross-sectional
   Study of Korean Blue Collar Workers Employed by Small Businesses
SO WORKPLACE HEALTH & SAFETY
LA English
DT Article
ID CORONARY-HEART-DISEASE; EFFORT-REWARD IMBALANCE; BODY-MASS INDEX; TO-HIP
   RATIO; BLOOD-PRESSURE; WAIST CIRCUMFERENCE; METABOLIC SYNDROME;
   MYOCARDIAL-INFARCTION; HEALTH-PROMOTION; JOB STRAIN
AB Actual cardiovascular disease (CVD) risk and related factors among blue collar workers employed by small businesses were investigated. This cross-sectional study of 238 Korean blue collar workers used surveys, anthropometric and blood pressure measurements, and blood sampling for lipid and glucose levels to answer the research questions. Multiple regression techniques were used to analyze study data. The prevalence of actual CVD risk among blue collar workers was 32 cases per 100 workers. A multiple regression model showed that a combination of individual, psychosocial, and work-related factors explained 34% of the variance in actual CVD risk. The significant predictors of actual CVD risk included knowledge of CVD risk, risk perception, job stress, and waist-to-hip ratio. It is important for clinicians to consider all of these significant predictors of actual CVD risk when designing an intervention program to reduce CVD among Korean blue collar workers.
C1 [Won, Jong Uk] Yonsei Univ, Dept Prevent Med & Publ Hlth, Seoul 120749, South Korea.
   [Won, Jong Uk] Yonsei Univ, Inst Occupat Hlth, Seoul 120749, South Korea.
   [Hong, Oi Saeng] Univ Calif San Francisco, Sch Nursing, Dept Community Hlth Syst, San Francisco, CA 94143 USA.
   [Hwang, Won Ju] Kyung Hee Univ, Coll Nursing Sci, Seoul 130701, South Korea.
C3 Yonsei University; Yonsei University; University of California System;
   University of California San Francisco; Kyung Hee University
RP Hwang, WJ (corresponding author), Kyung Hee Univ, Coll Nursing Sci, 26 Kyunghee Daero, Seoul 130701, South Korea.
EM hwangwj@khu.ac.kr
OI Won, Jong-Uk/0000-0002-9200-3297; Hwang, Won Ju/0000-0002-0498-6183
FU Kyung Hee University [KHU-20120488]; Pacific Rim Research Program
   Advanced Graduate Fellowship Program, University of California
FX This study was supported by a grant from Kyung Hee University in 2012
   (KHU-20120488). This study was also supported by the Pacific Rim
   Research Program Advanced Graduate Fellowship Program, University of
   California.
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NR 62
TC 6
Z9 7
U1 0
U2 9
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 2165-0799
EI 2165-0969
J9 WORKPLACE HEALTH SAF
JI Workplace Health Saf.
PD APR
PY 2013
VL 61
IS 4
BP 163
EP 171
DI 10.3928/21650799-20130327-17
PG 9
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA 173TW
UT WOS:000321103800004
PM 23557345
DA 2025-06-11
ER

PT S
AU Sun, SY
   Ji, YW
   Kersten, S
   Qi, L
AF Sun, Shengyi
   Ji, Yewei
   Kersten, Sander
   Qi, Ling
BE Cousins, RJ
TI Mechanisms of Inflammatory Responses in Obese Adipose Tissue
SO ANNUAL REVIEW OF NUTRITION, VOL 32
SE Annual Review of Nutrition
LA English
DT Review; Book Chapter
DE immunity; inflammation; obesity; diabetes; lipids; cytokines; adipocytes
ID DIET-INDUCED OBESITY; HIGH-FAT-DIET; INDUCED INSULIN-RESISTANCE;
   INTERLEUKIN-1 RECEPTOR ANTAGONIST; ALTERNATIVELY ACTIVATED MACROPHAGES;
   REGULATORY T-CELLS; ENDOPLASMIC-RETICULUM STRESS; NECROSIS-FACTOR-ALPHA;
   INVARIANT NKT CELLS; NF-KAPPA-B
AB The fields of immunology and metabolism are rapidly converging on adipose tissue. During obesity, many immune cells infiltrate or populate in adipose tissue and promote a low-grade chronic inflammation. Studies to date have suggested that perturbation of inflammation is critically linked to nutrient metabolic pathways and to obesity-associated complications such as insulin resistance and type 2 diabetes. Despite these advances, however, many open questions remain including how inflammatory responses are initiated and maintained, how nutrients impact the function of various immune populations, and how inflammatory responses affect systemic insulin sensitivity. Here we review recent studies on the roles of various immune cells at different phases of obesity and discuss molecular mechanisms underlying obesity-associated inflammation. Better understanding of the events occurring in adipose tissue will provide insights into the pathophysiological role of inflammation in obesity and shed light on the pathogenesis of obesity-associated metabolic syndrome.
C1 [Sun, Shengyi; Qi, Ling] Cornell Univ, Grad Program Biochem Mol & Cell Biol, Ithaca, NY 14853 USA.
   [Ji, Yewei; Kersten, Sander; Qi, Ling] Cornell Univ, Div Nutr Sci, Ithaca, NY 14853 USA.
   [Kersten, Sander] Wageningen Univ, Nutr Metab & Genom Grp, Div Human Nutr, NL-6700 EV Wageningen, Netherlands.
C3 Cornell University; Cornell University; Wageningen University & Research
RP Sun, SY (corresponding author), Cornell Univ, Grad Program Biochem Mol & Cell Biol, Ithaca, NY 14853 USA.
EM lq35@cornell.edu
RI Qi, Ling/KHE-3068-2024; , Yewei/F-5040-2014; Kersten, Sander/A-1116-2011
OI Sun, Shengyi/0000-0002-1734-3902; , Yewei/0000-0002-4249-6812; Kersten,
   Sander/0000-0003-4488-7734; Qi, Ling/0000-0001-8229-0184
FU NIAAA NIH HHS [R21 AA020351, R21AA020351] Funding Source: Medline; NIDDK
   NIH HHS [R01 DK082582, R01DK082582] Funding Source: Medline
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NR 166
TC 231
Z9 275
U1 0
U2 79
PU ANNUAL REVIEWS
PI PALO ALTO
PA 4139 EL CAMINO WAY, PO BOX 10139, PALO ALTO, CA 94303-0897 USA
SN 0199-9885
BN 978-0-8243-2832-0
J9 ANNU REV NUTR
JI Annu. Rev. Nutr.
PY 2012
VL 32
BP 261
EP +
DI 10.1146/annurev-nutr-071811-150623
PG 30
WC Nutrition & Dietetics
WE Book Citation Index – Science (BKCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA BBR29
UT WOS:000307963100014
PM 22404118
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Kim, JA
   Choi, KM
AF Kim, Jung A.
   Choi, Kyung Mook
TI Newly Discovered Adipokines: Pathophysiological Link Between Obesity and
   Cardiometabolic Disorders
SO FRONTIERS IN PHYSIOLOGY
LA English
DT Review
DE adipokine; pathophysiology; cardiometabolic disorders; adipocyte;
   obesity
ID GELATINASE-ASSOCIATED LIPOCALIN; ADIPOSE-TISSUE; ANTIINFLAMMATORY
   ADIPOKINE; INSULIN-RESISTANCE; LIVER-DISEASE; SERUM-LEVELS; OMENTIN-1;
   EXPRESSION; SFRP5; ASPROSIN
AB With the increasing prevalence of obesity, obesity-related problems such as cardiometabolic disorders (CMD), are also rapidly increasing. To prevent and alleviate the progressive course of CMD, it is important to discover the pathophysiological mechanisms between obesity and CMD. Adipose tissue is now recognized as an active endocrine organ that releases adipokines. Adipokines play a pivotal role in chronic low-grade inflammation, oxidative stress, and impaired insulin signaling, contributing to metabolic derangement and leading to CMD. Recent studies have provided substantial evidence supporting the association between adipokines and CMD. In this review, we highlight the pathophysiological action of adipokines in CMD that includes metabolic syndrome, type 2 diabetes, non-alcoholic fatty liver disease, and cardiovascular diseases. We focused on translational and clinical research of novel adipokines associated with metabolic and cardiovascular regulation. Exploration of the role of these adipokines connecting obesity and CMD may provide a perspective on adipokine-based therapeutic implications for CMD.
C1 [Kim, Jung A.; Choi, Kyung Mook] Korea Univ, Div Endocrinol & Metab, Dept Internal Med, Coll Med, Seoul, South Korea.
C3 Korea University; Korea University Medicine (KU Medicine)
RP Choi, KM (corresponding author), Korea Univ, Div Endocrinol & Metab, Dept Internal Med, Coll Med, Seoul, South Korea.
EM medica7@gmail.com
RI Kim, Jung/JAO-0332-2023; Choi, Kyung/C-4195-2018
OI Choi, Kyung Mook/0000-0001-6175-0225; Kim, Jung A/0000-0002-6595-6551
FU Korea University Research Funds [B1901301, K1809301, K2004951,
   A920197507]
FX KC was funded by the Korea University Research Funds (B1901301,
   K1809301, K2004951, and A920197507).
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NR 66
TC 20
Z9 20
U1 0
U2 11
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-042X
J9 FRONT PHYSIOL
JI Front. Physiol.
PD SEP 2
PY 2020
VL 11
AR 568800
DI 10.3389/fphys.2020.568800
PG 8
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA NS4SX
UT WOS:000572254300001
PM 32982804
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU van de Klashorst, D
   van den Elzen, A
   Weeteling, J
   Roberts, M
   Desai, T
   Bottoms, L
   Hughes, S
AF van de Klashorst, David
   van den Elzen, Amber
   Weeteling, Jasper
   Roberts, Michael
   Desai, Terun
   Bottoms, Lindsay
   Hughes, Samantha
TI Montmorency tart cherry (Prunus cerasus L.) acts as a calorie
   restriction mimetic that increases intestinal fat and lifespan in
   Caenorhabditis elegans
SO JOURNAL OF FUNCTIONAL FOODS
LA English
DT Article
DE Healthy aging; Pharyngeal pumping; Metabolic Syndrome; Lifespan;
   Polyphenol; Anthocyanins
ID VASCULAR FUNCTION; OXIDATIVE STRESS; C-ELEGANS; ANTHOCYANINS;
   CONSUMPTION; EXERCISE; SUPPLEMENTATION; INFLAMMATION; GENETICS; JUICE
AB Montmorency Tart Cherries, MTC, (Prunus cerasus L.) possess a high anthocyanin content as well as one of the highest oxygen radical absorbance capacities of fruits at common habitual portion sizes. MTC have been shown to contribute to reducing plasma lipids, plasma glucose and fat mass in rats and strikingly, similar effects are observed in humans. However, there is a paucity of research examining the molecular mechanisms by which such MTC effects are induced. Here, we show that when exposed to MTC, Caenorhabditis elegans display an extension of lifespan, with a corresponding increase in fat content and increase in neuromuscular function. Using RNA interference, we have confirmed that MTC is likely to function via the Peroxisome Proliferator-Activated Receptor (PPAR) signalling pathway. Further, consumption of MTC alters the pharyngeal pumping rate of worms which provides encouraging evidence that MTC may be operating as a calorie restriction mimetic via metabolic pathways.
C1 [van de Klashorst, David; van den Elzen, Amber; Weeteling, Jasper; Hughes, Samantha] HAN Univ Appl Sci, HAN BioCtr, Nijmegen, Netherlands.
   [Roberts, Michael; Desai, Terun; Bottoms, Lindsay] Univ Hertfordshire, Ctr Res Psychol & Sports Sci, Hatfield, Herts, England.
C3 University of Hertfordshire
RP Hughes, S (corresponding author), HAN Univ Appl Sci, HAN BioCtr, Nijmegen, Netherlands.
EM samantha.hughes@han.nl
RI Desai, Terun/AAD-2234-2022
OI Bottoms, Lindsay/0000-0003-4632-3764; Desai, Terun/0000-0001-8606-0458;
   Hughes, Samantha/0000-0001-8447-2563
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NR 76
TC 10
Z9 11
U1 1
U2 19
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1756-4646
EI 2214-9414
J9 J FUNCT FOODS
JI J. Funct. Food.
PD MAY
PY 2020
VL 68
AR 103890
DI 10.1016/j.jff.2020.103890
PG 10
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA LI9XT
UT WOS:000529829800007
OA gold
DA 2025-06-11
ER

PT J
AU Ramos-Romero, S
   Hereu, M
   Atienza, L
   Amézqueta, S
   Casas, J
   Muñoz, S
   Medina, I
   Miralles-Pérez, B
   Romeu, M
   Torres, JL
AF Ramos-Romero, Sara
   Hereu, Merce
   Atienza, Lidia
   Amezqueta, Susana
   Casas, Josefina
   Munoz, Silvia
   Medina, Isabel
   Miralles-Perez, Bernat
   Romeu, Marta
   Torres, Josep L.
TI The Buckwheat Iminosugar d-Fagomine Attenuates Sucrose-Induced Steatosis
   and Hypertension in Rats
SO MOLECULAR NUTRITION & FOOD RESEARCH
LA English
DT Article
DE blood pressure; d-fagomine; diabetes; fructose; metabolic syndrome
ID OBESITY; DIET; FRUCTOSE; LEPTIN; METABOLISM; RESISTANCE; FOOD
AB Scope This study examines the long-term functional effects of d-fagomine on sucrose-induced factors of metabolic dysfunctions and explores possible molecular mechanisms behind its action. Methods and results Wistar Kyoto rats are fed a 35% sucrose solution with d-fagomine (or not, for comparison) or mineral water (controls) for 24 weeks. The following are recorded: body weight; energy intake; glucose tolerance; plasma leptin concentration and lipid profile; populations of Bacteroidetes, Firmicutes, bacteroidales, clostridiales, enterobacteriales, and Escherichia coli in feces; blood pressure; urine uric acid and F-2t isoprostanes (F-2-IsoPs); perigonadal fat deposition; and hepatic histology and diacylglycerols (DAGs) in liver and adipose tissue. d-Fagomine reduces sucrose-induced hypertension, urine uric acid and F-2-IsoPs (markers of oxidative stress), steatosis, and liver DAGs, without significantly affecting perigonadal fat deposition, and impaired glucose tolerance. It also promotes excretion of enterobacteriales generated by the dietary intervention. Conclusion d-fagomine counteracts sucrose-induced steatosis and hypertension, presumably by reducing the postprandial levels of fructose in the liver.
C1 [Ramos-Romero, Sara; Hereu, Merce; Torres, Josep L.] CSIC, Inst Adv Chem Catalonia IQAC, ES-08034 Barcelona, Spain.
   [Ramos-Romero, Sara] Univ Barcelona, Fac Biol, Dept Cell Biol Physiol & Immunol, E-08028 Barcelona, Spain.
   [Atienza, Lidia] Puerta del Mar Univ Hosp, Dept Pathol, Cadiz 11009, Spain.
   [Amezqueta, Susana] Univ Barcelona, Dept Engn Quim & Quim Analit, E-08028 Barcelona, Spain.
   [Amezqueta, Susana] Univ Barcelona, Inst Biomed IBUB, E-08028 Barcelona, Spain.
   [Casas, Josefina] CSIC, Inst Adv Chem Catalonia IQAC, Dept Biol Chem, Res Unit Bioact Mol RUBAM, ES-08034 Barcelona, Spain.
   [Casas, Josefina] ISCIII, Ctr Biomed Res Hepat & Digest Dis CIBEREHD, Madrid 28029, Spain.
   [Munoz, Silvia; Medina, Isabel] CSIC, IIM, Vigo 36208, Spain.
   [Miralles-Perez, Bernat; Romeu, Marta] Univ Rovira & Virgili, Fac Med & Ciencies Salut, Reus 43201, Spain.
C3 Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Centro de
   Investigacion y Desarrollo Pascual Vila (CID-CSIC); CSIC - Instituto de
   Quimica Avanzada de Cataluna (IQAC); University of Barcelona;
   Universidad de Cadiz; Hospital Universitario Puerta del Mar; University
   of Barcelona; University of Barcelona; Consejo Superior de
   Investigaciones Cientificas (CSIC); CSIC - Centro de Investigacion y
   Desarrollo Pascual Vila (CID-CSIC); CSIC - Instituto de Quimica Avanzada
   de Cataluna (IQAC); CIBER - Centro de Investigacion Biomedica en Red;
   CIBEREHD; Instituto de Salud Carlos III; Consejo Superior de
   Investigaciones Cientificas (CSIC); CSIC - Instituto de Investigaciones
   Marinas (IIM); Universitat Rovira i Virgili
RP Ramos-Romero, S (corresponding author), CSIC, Inst Adv Chem Catalonia IQAC, ES-08034 Barcelona, Spain.; Ramos-Romero, S (corresponding author), Univ Barcelona, Fac Biol, Dept Cell Biol Physiol & Immunol, E-08028 Barcelona, Spain.
EM sara.ramos@iqac.csic.es
RI Torres, Josep/N-7256-2013; Casas, Josefina/L-7934-2014; ROMEU,
   MARTA/O-7129-2019; Ramos-Romero, Sara/AAH-6209-2020; Miralles-Pérez,
   Bernat/ABI-2034-2020; MEDINA, ISABEL/AAL-4012-2021; Ramos-Romero,
   Sara/K-8301-2017; ROMEU, MARTA/A-8468-2014
OI Casas, Josefina/0000-0002-7926-5209; MEDINA, ISABEL/0000-0002-1854-3359;
   Ramos-Romero, Sara/0000-0002-9293-4454; Miralles-Perez,
   Bernat/0000-0003-1294-7069; ROMEU, MARTA/0000-0002-2131-1858
FU Spanish Ministry of Economy, Industry and Competitiveness
   [AGL2013-49079-C2-1, 2-R, AGL2017-83599-R, BES2014-068592]
FX This work was supported by the Spanish Ministry of Economy, Industry and
   Competitiveness (grant numbers AGL2013-49079-C2-1, 2-R and
   AGL2017-83599-R, and graduate fellowship BES2014-068592 to M.H.). The
   authors thank Eva Dalmau for the DAG analysis. English language revision
   by Christopher Evans is also appreciated.
CR Amézqueta S, 2017, J AGR FOOD CHEM, V65, P4414, DOI 10.1021/acs.jafc.7b01026
   Amézqueta S, 2013, FOOD CHEM, V136, P1316, DOI 10.1016/j.foodchem.2012.09.038
   Blüher S, 2009, AM J CLIN NUTR, V89, p991S, DOI 10.3945/ajcn.2008.26788E
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NR 37
TC 10
Z9 10
U1 0
U2 21
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1613-4125
EI 1613-4133
J9 MOL NUTR FOOD RES
JI Mol. Nutr. Food Res.
PD JAN
PY 2020
VL 64
IS 1
AR 1900564
DI 10.1002/mnfr.201900564
EA NOV 2019
PG 10
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA KA4DG
UT WOS:000497895400001
PM 31657510
OA Green Submitted, Green Accepted
DA 2025-06-11
ER

PT J
AU Motaharinia, J
   Panahi, Y
   Barreto, GE
   Beiraghdar, F
   Sahebkar, A
AF Motaharinia, Javad
   Panahi, Yunes
   Barreto, George E.
   Beiraghdar, Fatemeh
   Sahebkar, Amirhossein
TI Efficacy of curcumin on prevention of drug-induced nephrotoxicity: A
   review of animal studies
SO BIOFACTORS
LA English
DT Review
DE acute kidney injury; Curcuma longa; Curcumin; nephroprotection;
   nephrotoxicity
ID GENTAMICIN-INDUCED NEPHROTOXICITY; CISPLATIN-INDUCED NEPHROTOXICITY;
   FATTY LIVER-DISEASE; NF-KAPPA-B; OXIDATIVE STRESS; PIPERINE COMBINATION;
   DIFLUORINATED CURCUMIN; PHYTOSOMAL CURCUMIN; LIPOSOMAL CURCUMIN;
   METABOLIC SYNDROME
AB Drug-induced nephrotoxicity is a frequent serious adverse effect, contributing to morbidity and increased healthcare utilization. Prevention or reversal is key. Curcumin has useful biological features that include antioxidant, anti-inflammatory, and anticancer properties. This review covers aspects of curcumin in relation to prevention of drug-induced nephrotoxicity: dosage and schedule, effect on kidney biomarkers and histological changes, and mechanisms of curcumin's protective effects. Despite success in some animal models, human studies and clinical administration of curcumin for nephroprotection remains limited due to difficulty in achieving therapeutic levels following oral administration and in determining the optimal dosing schedule. Lack of sufficient evidence from animal studies, coupled with low systemic bioavailability, continues to limit the utilization of curcumin in addressing and controlling drug-induced nephrotoxicity. Therefore, human studies are required to fully assess and validate the therapeutic potential of curcumin.
C1 [Motaharinia, Javad; Panahi, Yunes] Baqiyatallah Univ Med Sci, Syst Biol & Poisonings Inst, Chem Injuries Res Ctr, Tehran, Iran.
   [Panahi, Yunes] Baqiyatallah Univ Med Sci, Fac Pharm, Clin Pharm Dept, Tehran, Iran.
   [Barreto, George E.] Pontificia Univ Javeriana, Fac Ciencias, Dept Nutr & Bioquim, Bogota, Colombia.
   [Barreto, George E.] Univ Autonoma Chile, Inst Ciencias Biomed, Santiago, Chile.
   [Beiraghdar, Fatemeh] Baqiyatallah Univ Med Sci, Nephrol & Urol Res Ctr, Tehran, Iran.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Neurogen Inflammat Res Ctr, Mashhad, Razavi Khorasan, Iran.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Biotechnol Res Ctr, Mashhad 9177948564, Razavi Khorasan, Iran.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Sch Pharm, Mashhad, Razavi Khorasan, Iran.
C3 Baqiyatallah University of Medical Sciences (BMSU); Baqiyatallah
   University of Medical Sciences (BMSU); Pontificia Universidad Javeriana;
   Universidad Autonoma de Chile; Baqiyatallah University of Medical
   Sciences (BMSU); Mashhad University of Medical Sciences; Mashhad
   University of Medical Sciences; Mashhad University of Medical Sciences
RP Sahebkar, A (corresponding author), Mashhad Univ Med Sci, Pharmaceut Technol Inst, Biotechnol Res Ctr, Mashhad 9177948564, Razavi Khorasan, Iran.
EM sahebkara@mums.ac.ir
RI Motaharinia, Javad/U-4050-2019; Sahebkar, Amirhossein/B-5124-2018;
   Barreto, George E./LQJ-8882-2024
OI Motaharinia, Javad/0000-0003-2577-5067; Panahi,
   Yunes/0000-0002-2504-8356; Barreto, George E./0000-0002-6644-1971
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NR 87
TC 7
Z9 7
U1 2
U2 20
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0951-6433
EI 1872-8081
J9 BIOFACTORS
JI Biofactors
PD SEP
PY 2019
VL 45
IS 5
BP 690
EP 702
DI 10.1002/biof.1538
PG 13
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA JD6CP
UT WOS:000490069000005
PM 31246346
DA 2025-06-11
ER

PT J
AU Wang, RR
   Xiao, MC
   Zhang, YJ
   Ho, CT
   Wan, XC
   Li, DX
   Xie, ZW
AF Wang, Ruru
   Xiao, Menchao
   Zhang, Yujing
   Ho, Chi-Tang
   Wan, Xiaochun
   Li, Daxiang
   Xie, Zhongwen
TI RNA-Sequencing Analysis Reveals L-Theanine Regulating Transcriptional
   Rhythm Alteration in Vascular Smooth Muscle Cells Induced by
   Dexamethasone
SO JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
LA English
DT Article; Proceedings Paper
CT International Symposium on Chemistry, Flavor, and Health Effects of Tea
   held at the 256th American-Chemical-Society (ACS) Meeting
CY AUG 19-23, 2018
CL Boston, MA
SP Amer Chem Soc, Amer Chem Soc, Div Agr & Food Chem, Anhui Agr Univ, Int Joint Lab Tea Chem & Hlth Effects
DE L-theanine; biological rhythms; RNA-seq; circadian genes; VSMCs
ID CIRCADIAN GENE-EXPRESSION; TEA CAMELLIA-SINENSIS; METABOLIC SYNDROME;
   BLOOD-PRESSURE; CLOCK; CULTURE
AB L-Theanine, a unique amino acid in tea leaves, is known to have beneficial effects on stress relief, tumor suppression, and prevention of hypertension and cardiovascular diseases (CADs). The disruption of the circadian rhythm has been implied in the pathogenesis of CADs. However, it is unknown whether L-theanine has a modulatory effect on the vascular circadian rhythm. In this research, we have established a circadian gene expression model in rat vascular smooth muscle cells by dexamethasone induction. L-Theanine treatment enhanced the expression amplitude of clock genes, including Bmal1, Cry1, Reverb alpha, and Per2. Moreover, pairwise comparisons of the RNA-sequencing data showed that L-theanine is able to upregulate a ray of the rhythm genes and differentially expressed genes that are involved in vasoconstriction and actin cytoskeleton regulation pathways. Our data suggest that L-theanine changes the circadian gene rhythm involving in the process of vascular smooth muscle restructure.
C1 [Wang, Ruru; Xiao, Menchao; Zhang, Yujing; Wan, Xiaochun; Li, Daxiang; Xie, Zhongwen] Anhui Agr Univ, Sch Tea & Food Sci & Technol, State Key Lab Tea Plant Biol & Utilizat, Hefei 230036, Anhui, Peoples R China.
   [Wang, Ruru; Xiao, Menchao; Zhang, Yujing; Ho, Chi-Tang; Wan, Xiaochun; Li, Daxiang; Xie, Zhongwen] Anhui Agr Univ, Minist Educ, Int Joint Lab Tea Chem & Hlth Effects, Hefei 230036, Anhui, Peoples R China.
   [Ho, Chi-Tang] Rutgers State Univ, Dept Food Sci, 65 Dudley Rd, New Brunswick, NJ 08901 USA.
C3 Anhui Agricultural University; Anhui Agricultural University; Ministry
   of Education - China; Rutgers University System; Rutgers University New
   Brunswick
RP Li, DX; Xie, ZW (corresponding author), Anhui Agr Univ, Sch Tea & Food Sci & Technol, State Key Lab Tea Plant Biol & Utilizat, Hefei 230036, Anhui, Peoples R China.; Li, DX; Xie, ZW (corresponding author), Anhui Agr Univ, Minist Educ, Int Joint Lab Tea Chem & Hlth Effects, Hefei 230036, Anhui, Peoples R China.
EM dxli@ahau.edu.cn; zhongwenxie@ahau.edu.cn
RI Xie, Zhongwen/I-7705-2019; li, daxiang/H-6815-2017; Ho,
   Chi-Tang/B-5629-2012
OI Xie, Zhongwen/0000-0002-3080-4881; RURU, WANG/0000-0002-7743-2296
FU National Sciences Foundation of China [31571207]; Department of Sciences
   and Technology of Anhui Province [17030701017, 2016-188]; Anhui Province
   Talent Team Program
FX This research was funded by the National Sciences Foundation of China to
   Zhongwen Xie (Grant 31571207), a key grant from the Department of
   Sciences and Technology of Anhui Province to Zhongwen Xie (Grant
   17030701017), a grant for Nutrition and Quality & Safety of Agricultural
   Products from the Anhui Province Talent Team Program to Zhongwen Xie, a
   grant for Anhui Featured Agricultural Development Project (Grant
   2016-188), and a grant for supporting animal core facility in Anhui
   Agricultural University from the Department of Sciences and Technology
   of Anhui Province.
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NR 47
TC 16
Z9 17
U1 2
U2 30
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0021-8561
EI 1520-5118
J9 J AGR FOOD CHEM
JI J. Agric. Food Chem.
PD MAY 15
PY 2019
VL 67
IS 19
BP 5413
EP 5422
DI 10.1021/acs.jafc.8b05057
PG 10
WC Agriculture, Multidisciplinary; Chemistry, Applied; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Agriculture; Chemistry; Food Science & Technology
GA HY8DO
UT WOS:000468367800011
PM 30685977
DA 2025-06-11
ER

PT J
AU Williamson, G
   Sheedy, K
AF Williamson, Gary
   Sheedy, Katherine
TI Effects of Polyphenols on Insulin Resistance
SO NUTRIENTS
LA English
DT Review
DE polyphenol; starch digestion; glucose; postprandial; GLUT4; akt;
   diabetes
ID BETA-CELL LINE; TYPE-2 DIABETES-MELLITUS; HOMEOSTASIS MODEL ASSESSMENT;
   CARDIOVASCULAR RISK-FACTORS; GREEN TEA; HIGH-FAT; METABOLIC-SYNDROME;
   GLYCEMIC CONTROL; OXIDATIVE STRESS; GLUCOSE-TRANSPORTER
AB Insulin resistance (IR) is apparent when tissues responsible for clearing glucose from the blood, such as adipose and muscle, do not respond properly to appropriate signals. IR is estimated based on fasting blood glucose and insulin, but some measures also incorporate an oral glucose challenge. Certain (poly)phenols, as supplements or in foods, can improve insulin resistance by several mechanisms including lowering postprandial glucose, modulating glucose transport, affecting insulin signalling pathways, and by protecting against damage to insulin-secreting pancreatic beta-cells. As shown by intervention studies on volunteers, the most promising candidates for improving insulin resistance are (-)-epicatechin, (-)-epicatechin-containing foods and anthocyanins. It is possible that quercetin and phenolic acids may also be active, but data from intervention studies are mixed. Longer term and especially dose-response studies on mildly insulin resistant participants are required to establish the extent to which (poly)phenols and (poly)phenol-rich foods may improve insulin resistance in compromised groups.
C1 [Williamson, Gary; Sheedy, Katherine] Monash Univ, Fac Med Nursing & Hlth Sci, Monash Hlth, Dept Nutr Dietet & Food,Sch Clin Sci,BASE Facil, 264 Ferntree Gully Rd, Notting Hill, Vic 3168, Australia.
C3 Monash University
RP Williamson, G (corresponding author), Monash Univ, Fac Med Nursing & Hlth Sci, Monash Hlth, Dept Nutr Dietet & Food,Sch Clin Sci,BASE Facil, 264 Ferntree Gully Rd, Notting Hill, Vic 3168, Australia.
EM gary.williamson1@monash.edu; katherine-s@live.com.au
RI Williamson, Gary/AAE-9665-2019
OI Williamson, Gary/0000-0002-5624-6267
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NR 172
TC 73
Z9 78
U1 4
U2 48
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD OCT
PY 2020
VL 12
IS 10
AR 3135
DI 10.3390/nu12103135
PG 18
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA OM7YQ
UT WOS:000586235500001
PM 33066504
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Fan, NG
   Zhang, LJ
   Xia, ZH
   Peng, L
   Wang, YF
   Peng, YD
AF Fan, Nengguang
   Zhang, Lijuan
   Xia, Zhenhua
   Peng, Liang
   Wang, Yufan
   Peng, Yongde
TI Sex-Specific Association between Serum Uric Acid and Nonalcoholic Fatty
   Liver Disease in Type 2 Diabetic Patients
SO JOURNAL OF DIABETES RESEARCH
LA English
DT Article
ID HEPATIC STEATOSIS; METABOLIC SYNDROME; METAANALYSIS; GENERATION; STRESS;
   LEVEL; RISK
AB Across-sectional study was performed in 541 type 2 diabetic patients to determine the relationship between serum uric acid (SUA) and NAFLD in type 2 diabetic patients. Clinical parameters including SUA were determined and NAFLD was diagnosed by ultrasonography. SUA was significantly higher in type 2 diabetic subjects with NAFLD than in those without NAFLD in men, but not in women. Furthermore, the prevalence rate of NAFLD increased progressively across the sex-specific SUA tertiles only in men (37.9%, 58.6%, and 72.6%, resp., P for trend < 0.001). After adjusting for confounding factors, the odd ratios (95% CI) for NAFLD were 1 (reference), 2.93 (95% CI 1.25-6.88), and 3.93 (95% CI 1.55-9.98), respectively, across the tertiles of SUA in men. Contrastingly, SUA levels in women were not independently associated with the risk of NAFLD. Our data suggests that SUA is specifically associated with NAFLD in male type 2 diabetic subjects, independent of insulin resistance and other metabolic factors.
C1 [Fan, Nengguang; Wang, Yufan; Peng, Yongde] Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 1, Dept Endocrinol & Metab, Shanghai 200080, Peoples R China.
   [Zhang, Lijuan; Xia, Zhenhua] Shanghai Songjiang Ctr Hosp, Dept Endocrinol, Shanghai 201600, Peoples R China.
   [Peng, Liang] Shanghai Songjiang Ctr Hosp, Dept Lab Med, Shanghai 201600, Peoples R China.
C3 Shanghai Jiao Tong University
RP Peng, YD (corresponding author), Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 1, Dept Endocrinol & Metab, Shanghai 200080, Peoples R China.
EM yongdepeng0908@126.com
FU National Natural Science Foundation of China [81400785]
FX This work was supported by grant from the National Natural Science
   Foundation of China (81400785).
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NR 28
TC 38
Z9 40
U1 0
U2 4
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2314-6745
EI 2314-6753
J9 J DIABETES RES
JI J. Diabetes Res.
PY 2016
VL 2016
AR 3805372
DI 10.1155/2016/3805372
PG 6
WC Endocrinology & Metabolism; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Research & Experimental Medicine
GA DP8KS
UT WOS:000378747600001
PM 27382573
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Kouidrat, Y
   Amad, A
   De Hert, M
AF Kouidrat, Youssef
   Amad, Ali
   De Hert, Marc
TI Emerging Drugs and Indications for Cardio-Metabolic Disorders in People
   with Severe Mental Illness
SO CURRENT PHARMACEUTICAL DESIGN
LA English
DT Article
DE Antipsychotic-induced weight gain; bipolar disorder; cardiovascular
   risk; metformin; metabolic syndrome; off-label use; schizophrenia;
   severe mental illness
ID INDUCED WEIGHT-GAIN; GLUCAGON-LIKE PEPTIDE-1; END-PRODUCTS AGES;
   CARDIOVASCULAR RISK-FACTORS; DOUBLE-BLIND; OXIDATIVE STRESS; BIPOLAR
   DISORDER; SCHIZOAFFECTIVE PATIENTS; ADVANCED GLYCOXIDATION;
   SCHIZOPHRENIA-PATIENTS
AB Patients with severe mental illnesses, such as schizophrenia and bipolar disorder, are at increased risk of developing metabolic disorders including obesity, diabetes, and dyslipidemia. All of these comorbidities increase the risk of cardiovascular disease and mortality. Different approaches, including diet and lifestyle modifications, behavioral therapy and switching antipsychotic agents, have been proposed to manage these metabolic abnormalities. However, these interventions may be insufficient, impractical or fail to counteract the metabolic dysregulation. Consequently, a variety of pharmacological agents such as antidiabetic drugs, have been studied in an attempt to reverse the weight gain and metabolic abnormalities evident in these patients. Despite a significant effect, many of these treatments are used off-label. This qualitative review focuses on pharmacological agents that could offer significant benefits in the management of cardio-metabolic disorders associated with serious mental illness.
C1 [Kouidrat, Youssef] Hop Maritime, AP HP, Dept Nutr, F-62600 Berck Sur Mer, France.
   [Amad, Ali] Kings Coll London, Inst Psychiat Psychol & Neurosci, London, England.
   [De Hert, Marc] KU Leuven Univ Leuven, Dept Neurosci, B-3000 Leuven, Belgium.
   [De Hert, Marc] Zorg KU Leuven, Univ Psychiat Ctr, Louvain, Belgium.
C3 Assistance Publique Hopitaux Paris (APHP); Hopital Universitaire
   Maritime de Berck - APHP; University of London; King's College London;
   KU Leuven
RP De Hert, M (corresponding author), Catholic Univ Louvain, Univ Psychiat Ctr, Leuvensesteenweg 517, B-3070 Kortenberg, Belgium.
EM marc.de.hert@uc-kortenberg.be
RI De Hert, Marc/AAH-6090-2021
OI Amad, Ali/0000-0002-9029-2910; De Hert, Marc/0000-0003-4255-5920
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NR 85
TC 10
Z9 10
U1 0
U2 14
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1381-6128
EI 1873-4286
J9 CURR PHARM DESIGN
JI Curr. Pharm. Design
PY 2015
VL 21
IS 23
BP 3317
EP 3324
DI 10.2174/1381612821666150619093128
PG 8
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA CN9DA
UT WOS:000358745400007
PM 26088113
DA 2025-06-11
ER

PT J
AU Kuller, LH
AF Kuller, Lewis H.
TI Metformin Use Among Individuals at Risk for Type 2 Diabetes
SO CURRENT DIABETES REPORTS
LA English
DT Article
DE Metformin; Type 2 diabetes; Coronary heart disease; Insulin; Cancer,
   prevention; Obesity; Screening
ID INCIDENT CARDIOVASCULAR-DISEASE; FASTING PLASMA-GLUCOSE;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; HEPATIC STEATOSIS; PROGNOSTIC
   VALUE; FATTY LIVER; LIFE-STYLE; ALL-CAUSE; HEALTH
AB Excess total and cardiovascular morbidity and mortality remain very high among those with type 2 diabetes versus those without diabetes. Clinical trials to lower blood glucose have been disappointing probably because the participants were too late in the natural history of diabetes and already had extensive vascular disease. Insulin resistance measured simply by elevated fasting blood insulin is an early marker of beta-cell stress and peripheral insulin resistance. Metformin will prevent development of diabetes among patients with impaired fasting glucose but only for the short term. Metformin reduces risk of coronary heart disease. The drug is safe, low cost, and may also prevent cancer. The combination of diet and exercise followed by metformin in the early phase of "insulin resistance" may reduce or delay both atherosclerosis and arteriosclerosis complications associated with diabetes. Preventive therapy must begin much earlier than before clinical diagnosis of diabetes and aim to initially lower blood insulin levels or insulin resistance.
C1 Univ Pittsburgh, Grad Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA 15261 USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE); University
   of Pittsburgh
RP Kuller, LH (corresponding author), Univ Pittsburgh, Grad Sch Publ Hlth, Dept Epidemiol, 550 Bellefield Profess Bldg,130 N Bellefield Ave, Pittsburgh, PA 15261 USA.
EM kullerl@edc.pitt.edu
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NR 94
TC 4
Z9 4
U1 0
U2 4
PU CURRENT MEDICINE GROUP
PI PHILADELPHIA
PA 400 MARKET STREET, STE 700, PHILADELPHIA, PA 19106 USA
SN 1534-4827
EI 1539-0829
J9 CURR DIABETES REP
JI Curr. Diabetes Rep.
PD JUN
PY 2012
VL 12
IS 3
BP 265
EP 273
DI 10.1007/s11892-012-0263-x
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 935JQ
UT WOS:000303515400008
PM 22399368
DA 2025-06-11
ER

PT J
AU Katsiki, N
   Nikolic, D
   Montalto, G
   Banach, M
   Mikhailidis, DP
   Rizzo, M
AF Katsiki, Niki
   Nikolic, Dragana
   Montalto, Giuseppe
   Banach, Maciej
   Mikhailidis, Dimitri P.
   Rizzo, Manfredi
TI The Role of Fibrate Treatment in Dyslipidemia: An Overview
SO CURRENT PHARMACEUTICAL DESIGN
LA English
DT Article
DE Fibrates; dyslipidemia; cardiovascular risk; diabetes
ID LOW-DENSITY-LIPOPROTEIN; CORONARY-ARTERY-DISEASE; PROLIFERATOR-ACTIVATED
   RECEPTOR; TYPE-2 DIABETES-MELLITUS; CHOLESTERYL ESTER TRANSFER; TERM
   FENOFIBRATE THERAPY; LIPID-LOWERING DRUGS; APOLIPOPROTEIN-A-I; HIGH-RISK
   PATIENTS; COMBINATION THERAPY
AB Dyslipidemia, and especially atherogenic dyslipidemia, a combination of small low-density lipoproteins cholesterol (LDL-C), decreased high-density lipoprotein cholesterol (HDL-C) and increased triglyceride (TG) concentrations, represents a major cardiovascular (CV) risk factor. Nuclear receptor peroxisome proliferator-activated receptors (PPARs) are involved in the regulation of lipid metabolism; PPAR ligands are used to treat dyslipidemias.
   Fibrates have a major impact on TG metabolism as well as on modulating LDL size and subclasses. Fibrates target atherogenic dyslipidemia by increasing plasma HDL-C concentrations and decreasing small dense LDL (sdLDL) particles and TGs, thus contributing to dyslipidemia management, particularly in patients with diabetes (DM) or the metabolic syndrome (MetS). Furthermore, fibrates exert beneficial effects on adipokines, inflammation and oxidative stress as well as neuroprotective properties. However, further studies are needed to define the role of fibrates in the prevention of CV events. We review the effects of fibrates on atherogenic dyslipidemia and CV risk reduction.
C1 [Katsiki, Niki] Aristotle Univ Thessaloniki, Hippokrat Hosp, Sch Med, Propedeut Dept Internal Med 2, GR-54006 Thessaloniki, Greece.
   [Nikolic, Dragana; Montalto, Giuseppe; Rizzo, Manfredi] Univ Palermo, Dept Internal Med & Med Specialties, I-90133 Palermo, Italy.
   [Banach, Maciej] Med Univ Lodz, Dept Hypertens, Lodz, Poland.
   [Mikhailidis, Dimitri P.] UCL, Sch Med, Dept Clin Biochem, Vasc Dis Prevent Clin, London NW3 2QG, England.
C3 Aristotle University of Thessaloniki; University of Palermo; Medical
   University Lodz; University of London; University College London; UCL
   Medical School
RP Mikhailidis, DP (corresponding author), UCL, Sch Med, Dept Clin Biochem, Vasc Dis Prevent Clin, Royal Free Hosp Campus,Pond St, London NW3 2QG, England.
EM MIKHAILIDIS@aol.com
RI Mikhailidis, Dimitri/A-1869-2013; RIZZO, MANFREDI/GZL-0551-2022; Banach,
   Maciej/A-1271-2009; KATSIKI, NIKI/ADE-7999-2022
OI Nikolic, Dragana/0000-0001-9572-9651; MONTALTO,
   Giuseppe/0000-0002-8731-8577; Banach, Maciej/0000-0001-6690-6874;
   KATSIKI, NIKI/0000-0003-0894-2644; RIZZO, Manfredi/0000-0002-9549-8504
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BP 3124
EP 3131
PG 8
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 119DH
UT WOS:000317077100020
PM 23317397
DA 2025-06-11
ER

PT J
AU Canal, MP
   Nini, KA
   Baez, MV
AF Canal, Maria Pilar
   Nini, Karen Agustina
   Baez, Maria Veronica
TI Impaired fasting glucose, oxidative distress, and cognitive impairment.
   Is this the starting point on DBT cognitive decline?
SO FRONTIERS IN AGING NEUROSCIENCE
LA English
DT Review
DE impaired fasting glucose; redox imbalance; cognitive decline;
   cross-sectional studies; DBT2
ID ALZHEIMERS-DISEASE; DIABETES-MELLITUS; STRESS; RISK; NEURODEGENERATION;
   INFLAMMATION; PERFORMANCE; IMPACT
AB Different studies performed in human patients, animal models, and in vitro cell cultures, show a correlation between type 2 diabetes (DBT2) and certain neurodegenerative pathologies. Also, it was proposed that increased inflammation and- or oxidative distress are a possible cause of DBT2-accelerated cognitive decline. The onset of DBT2 is characterized by an increase in blood glucose levels due to (an inability of the body's cells to use insulin properly) called impaired fasting glucose (IFG). Genetic and/or molecular causes of IFG have not yet been established, but metabolic syndrome, obesity, unbalanced diets, and sedentary lifestyle would be responsible, at least in part, for the multiplication in the number of this disease. It has been proposed that hyperglycemia itself causes an imbalance in the redox state and could compromise blood-brain barrier (BBB) causing neurodegeneration. For this reason, we propose, in this review, to evaluate the available data about redox state and neurocognitive studies during the IFG period.
C1 [Canal, Maria Pilar; Nini, Karen Agustina; Baez, Maria Veronica] CONICET UBA, Inst Biol Celular & Neurociencia, Buenos Aires, Argentina.
   [Baez, Maria Veronica] Univ Buenos Aires, Fac Med, UA Histol Embriol Biol Celular & Genet 1, Buenos Aires, Argentina.
C3 Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET);
   University of Buenos Aires; CONICET UBA; University of Buenos Aires
RP Baez, MV (corresponding author), CONICET UBA, Inst Biol Celular & Neurociencia, Buenos Aires, Argentina.; Baez, MV (corresponding author), Univ Buenos Aires, Fac Med, UA Histol Embriol Biol Celular & Genet 1, Buenos Aires, Argentina.
EM mbaez@fmed.uba.ar
RI Baez, Veronica/ABF-9940-2021
OI Baez, Maria Veronica/0000-0001-5105-2888
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NR 38
TC 2
Z9 2
U1 0
U2 5
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1663-4365
J9 FRONT AGING NEUROSCI
JI Front. Aging Neurosci.
PD JUL 26
PY 2022
VL 14
AR 911331
DI 10.3389/fnagi.2022.911331
PG 6
WC Geriatrics & Gerontology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology; Neurosciences & Neurology
GA 3Q4OT
UT WOS:000838213300001
PM 35959297
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Tundis, R
   Tenuta, MC
   Loizzo, MR
   Bonesi, M
   Finetti, F
   Trabalzini, L
   Deguin, B
AF Tundis, Rosa
   Tenuta, Maria C.
   Loizzo, Monica R.
   Bonesi, Marco
   Finetti, Federica
   Trabalzini, Lorenza
   Deguin, Brigitte
TI Vaccinium Species (Ericaceae): From Chemical Composition to
   Bio-Functional Activities
SO APPLIED SCIENCES-BASEL
LA English
DT Review
DE Vaccinium species; phytochemicals; berry; leaf; anti-inflammatory
   pathways; endothelial dysfunction
ID PERIPHERAL ARTERIAL DYSFUNCTION; ORGANIC-ACID COMPOSITION;
   PHENOLIC-COMPOUNDS; BLUEBERRY ANTHOCYANINS; ANTIOXIDANT CAPACITY;
   ENDOTHELIAL DYSFUNCTION; BIOACTIVE CONSTITUENTS; CRANBERRY PRODUCTS;
   METABOLIC SYNDROME; OXIDATIVE STRESS
AB The genus Vaccinium L. (Ericaceae) includes more than 450 species, which mainly grow in cooler areas of the northern hemisphere. Vaccinium species have been used in traditional medicine of different cultures and the berries are widely consumed as food. Indeed, Vaccinium supplement-based herbal medicine and functional food, mainly from V. myrtillus and V. macrocarpon, are used in Europe and North America. Biological studies support traditional uses since, for many Vaccinium components, important biological functions have been described, including antioxidant, antitumor, anti-inflammatory, antidiabetic and endothelium protective activities. Vaccinium components, such as polyphenols, anthocyanins and flavonoids, are widely recognized as modulators of cellular pathways involved in pathological conditions, thus indicating that Vaccinium may be an important source of bioactive molecules. This review aims to better describe the bioactivity of Vaccinium species, focusing on anti-inflammatory and endothelial protective cellular pathways, modulated by their components, to better understand their importance for public health.
C1 [Tundis, Rosa; Tenuta, Maria C.; Loizzo, Monica R.; Bonesi, Marco] Univ Calabria, Dept Pharm Hlth & Nutr Sci, I-87036 Arcavacata Di Rende, Italy.
   [Tenuta, Maria C.; Deguin, Brigitte] Univ Paris, UFR Pharm Paris, UMR 8038, CiTCoM,CNRS, F-75006 Paris, France.
   [Finetti, Federica; Trabalzini, Lorenza] Univ Siena, Dept Biotechnol Chem & Pharm, I-53100 Siena, Italy.
C3 University of Calabria; Universite Paris Cite; Centre National de la
   Recherche Scientifique (CNRS); University of Siena
RP Tundis, R (corresponding author), Univ Calabria, Dept Pharm Hlth & Nutr Sci, I-87036 Arcavacata Di Rende, Italy.
EM rosa.tundis@unical.it; mary.tn2006@hotmail.it;
   monica_rosa.loizzo@unical.it; marco.bonesi@unical.it; finetti2@unisi.it;
   lorenza.trabalzini@unisi.it; brigitte.deguin@parisdescartes.fr
RI Finetti, Federica/J-9089-2016
OI Loizzo, Monica Rosa/0000-0002-6050-9357; Tundis,
   Rosa/0000-0002-3713-4403; Tenuta, Maria Concetta/0000-0001-9642-8092;
   Trabalzini, Lorenza/0000-0002-0850-7186
FU MIUR (Progetto Dipartimento di Eccellenza) [2018-2022]
FX This work was supported by MIUR (Progetto Dipartimento di Eccellenza
   2018-2022) to L.T. and F.F.
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NR 140
TC 32
Z9 33
U1 2
U2 50
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3417
J9 APPL SCI-BASEL
JI Appl. Sci.-Basel
PD JUN
PY 2021
VL 11
IS 12
AR 5655
DI 10.3390/app11125655
PG 19
WC Chemistry, Multidisciplinary; Engineering, Multidisciplinary; Materials
   Science, Multidisciplinary; Physics, Applied
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Engineering; Materials Science; Physics
GA SY5WO
UT WOS:000665958100001
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Quiñones, M
   Ferno, J
   Al-Massadi, O
AF Quinones, Mar
   Ferno, Johan
   Al-Massadi, Omar
TI Ghrelin and liver disease
SO REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
LA English
DT Article
DE Ghrelin; NAFLD; NASH; Hepatic fibrosis; Lipid metabolism; Obesity
ID DES-ACYL GHRELIN; BINDING PROTEIN-BETA; CIRCADIAN CLOCK; FOOD-INTAKE;
   SERUM BUTYRYLCHOLINESTERASE; HEPATOCELLULAR INJURY; OXIDATIVE STRESS;
   LIPID-METABOLISM; CB1 RECEPTOR; GROWTH
AB Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are two of the most common liver diseases associated with obesity, type 2 diabetes and metabolic syndrome. The prevalence of these conditions are increasingly rising and presently there is not a pharmacological option available in the market. Elucidation of the mechanism of action and the molecular underpinnings behind liver disease could help to better understand the pathophysiology of these illnesses. In this sense, in the last years modulation of the ghrelin system in preclinical animal models emerge as a promising therapeutic tool. In this review, we compile the latest knowledge of the modulation of ghrelin system and its intracellular pathways that regulates lipid metabolism, hepatic inflammation and liver fibrosis. We also describe novel processes implicated in the regulation of liver disease by ghrelin, such as autophagy or dysregulated circadian rhythms. In conclusion, the information displayed in this review support that the ghrelin system could be an appealing strategy for the treatment of liver disease.
C1 [Quinones, Mar] Univ Santiago de Compostela, Inst Invest Sanitaria, CIMUS, Dept Physiol, Santiago De Compostela 15782, Spain.
   [Quinones, Mar] CIBER Fisiopatol Obesidad & Nutr CIBERobn, Santiago De Compostela 15706, Spain.
   [Ferno, Johan] Haukeland Hosp, Hormone Lab, Bergen, Norway.
   [Al-Massadi, Omar] INSERM, UMR S1270, F-75005 Paris, France.
   [Al-Massadi, Omar] Sorbonne Univ, Fac Sci & Ingn, F-75005 Paris, France.
   [Al-Massadi, Omar] Inst Fer Moulin, INSERM, 17 Rue Fer Moulin, F-75005 Paris, France.
C3 Universidade de Santiago de Compostela; CIBER - Centro de Investigacion
   Biomedica en Red; CIBEROBN; University of Bergen; Haukeland University
   Hospital; Institut National de la Sante et de la Recherche Medicale
   (Inserm); Sorbonne Universite; Institut National de la Sante et de la
   Recherche Medicale (Inserm); Sorbonne Universite
RP Al-Massadi, O (corresponding author), INSERM, UMR S1270, F-75005 Paris, France.; Al-Massadi, O (corresponding author), Sorbonne Univ, Fac Sci & Ingn, F-75005 Paris, France.; Al-Massadi, O (corresponding author), Inst Fer Moulin, INSERM, 17 Rue Fer Moulin, F-75005 Paris, France.
EM omar.al-massadi@inserm.fr
RI Quiñones, Mar/AAA-9225-2020; Al-Massadi, Omar/C-1526-2017
OI Al-Massadi, Omar/0000-0003-0645-6159; Quinones, Mar/0000-0003-0180-2147
FU FEDER funds; Galician Government (Xunta de Galicia) [ED481B2018/004]; 
   [2018-PG013]
FX This work is supported by grants of Xunta (MQ: 2018-PG013). Centro de
   Investigacion Biomedica en Red (CIBER) de Fisiopatologia de la Obesidad
   y Nutricion (CIBERobn). Western Norway Regional Health Authority (Helse
   Vest RHF), CIBERobn is an initiative of the Instituto de Salud Carlos
   III (ISCIII) of Spain which is supported by FEDER funds. M.Q. is a
   recipient of a Postdoctoral contract from Galician Government (Xunta de
   Galicia ED481B2018/004). The figures were generated by using materials
   from Servier Medical Art (Servier) under consideration of a Creative
   Commons Attribution 3.0 Unported License.
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NR 119
TC 35
Z9 38
U1 0
U2 18
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1389-9155
EI 1573-2606
J9 REV ENDOCR METAB DIS
JI Rev. Endocr. Metab. Disord.
PD MAR
PY 2020
VL 21
IS 1
BP 45
EP 56
DI 10.1007/s11154-019-09528-6
EA NOV 2019
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA LB9LJ
UT WOS:000498741000001
PM 31758299
DA 2025-06-11
ER

PT J
AU Lee, C
   Coe, CL
   Ryff, CD
AF Lee, Chioun
   Coe, Christopher L.
   Ryff, Carol D.
TI Social Disadvantage, Severe Child Abuse, and Biological Profiles in
   Adulthood
SO JOURNAL OF HEALTH AND SOCIAL BEHAVIOR
LA English
DT Article
DE biomarkers; childhood abuse; gender; health; life course; social class
ID EARLY-LIFE ADVERSITY; ARTERY RISK DEVELOPMENT; SOCIOECONOMIC-STATUS;
   METABOLIC SYNDROME; ALLOSTATIC LOAD; PHYSICAL ABUSE; RETROSPECTIVE
   REPORTS; GENDER-DIFFERENCES; CORTISOL-LEVELS; UNITED-STATES
AB Guided by the stress process model and the life course perspective, we hypothesize: (1) that childhood abuse is concentrated, in terms of type and intensity, among socially disadvantaged individuals, and (2) that experiencing serious abuse contributes to poor biological profiles in multiple body systems in adulthood. Data came from the Biomarker subsample of Midlife in the United States (2004-2006). We used latent class analysis to identify distinct profiles of childhood abuse, each reflecting a combination of type and severity. Results indicate that disadvantaged groups, women, and those from disadvantaged families are at greater risk of experiencing more severe and multiple types of abuse. Those with more severe and multifaceted childhood abuse show greater physiological dysregulation. Childhood abuse experiences partially accounted for the social status differences in physiological profiles. Our findings underscore that differential exposure to serious childhood stressors plays a significant role in gender and class inequalities in adult health.
C1 [Lee, Chioun; Ryff, Carol D.] Univ Wisconsin Madison, Inst Aging, Madison, WI USA.
   [Coe, Christopher L.] Univ Wisconsin Madison, Harlow Ctr Biol Psychol, Madison, WI USA.
   [Ryff, Carol D.] Univ Wisconsin Madison, Psychol, Madison, WI USA.
C3 University of Wisconsin System; University of Wisconsin Madison;
   University of Wisconsin System; University of Wisconsin Madison;
   University of Wisconsin System; University of Wisconsin Madison
RP Lee, C (corresponding author), Univ Wisconsin Madison, RM 2435 Med Sci Ctr,1300 Univ Ave, Madison, WI 53706 USA.
EM clee365@wisc.edu
OI Lee, Chioun/0000-0002-6886-8397
FU NIA K99 [K99AG052458]; National Institute of Child Health and Human
   Development [T32HD049302]; Clinical and Translational Science Award
   (CTSA) program, through the NIH National Center for Advancing
   Translational Sciences (NCATS) [UL1TR000427]; National Institute on
   Aging [P01AG020166]; John D. and Catherine T. MacArthur Foundation
   Research Network on Successful Midlife Development; General Clinical
   Research Centers Program [M01RR023942, M01RR00865]
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: Chioun Lee
   is currently funded by a NIA K99 (K99AG052458). She was also supported
   by a training grant from the National Institute of Child Health and
   Human Development (T32HD049302) and by the Clinical and Translational
   Science Award (CTSA) program, through the NIH National Center for
   Advancing Translational Sciences (NCATS), grant UL1TR000427. The work
   was also supported by the National Institute on Aging (P01AG020166) to
   conduct a longitudinal follow-up of the MIDUS investigation. The
   original study was supported by the John D. and Catherine T. MacArthur
   Foundation Research Network on Successful Midlife Development. Support
   also came from M01RR023942 (Georgetown) and M01RR00865 (UCLA) from the
   General Clinical Research Centers Program. The content is solely the
   responsibility of the authors and does not necessarily represent the
   official views of the NIH.
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NR 76
TC 27
Z9 32
U1 1
U2 41
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0022-1465
EI 2150-6000
J9 J HEALTH SOC BEHAV
JI J. Health Soc. Behav.
PD SEP
PY 2017
VL 58
IS 3
BP 371
EP 386
DI 10.1177/0022146516685370
PG 16
WC Public, Environmental & Occupational Health; Psychology, Social; Social
   Sciences, Biomedical; Sociology
WE Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; Psychology; Biomedical
   Social Sciences; Sociology
GA FE4ZX
UT WOS:000408222900007
PM 29353512
OA Green Accepted, Green Submitted
DA 2025-06-11
ER

PT J
AU Park, MH
   Jin, HK
   Min, WK
   Lee, WW
   Lee, JE
   Akiyama, H
   Herzog, H
   Enikolopov, GN
   Schuchman, EH
   Bae, JS
AF Park, Min Hee
   Jin, Hee Kyung
   Min, Woo-Kie
   Lee, Won Woo
   Lee, Jeong Eun
   Akiyama, Haruhiko
   Herzog, Herbert
   Enikolopov, Grigori N.
   Schuchman, Edward H.
   Bae, Jae-sung
TI Neuropeptide Y regulates the hematopoietic stem cell microenvironment
   and prevents nerve injury in the bone marrow
SO EMBO JOURNAL
LA English
DT Article
DE bone marrow microenvironment; hematopoietic stem cell; neuropeptide Y;
   regeneration; sympathetic nervous system
ID METABOLIC SYNDROME; TGF-BETA; NICHE; MACROPHAGES; GROWTH; STRESS; MICE;
   NEUROTOXICITY; REPOPULATION; REGENERATION
AB Many reports have revealed the importance of the sympathetic nervous system (SNS) in the control of the bone marrow environment. However, the specific role of neuropeptide Y (NPY) in this process has not been systematically studied. Here we show that NPY-deficient mice have significantly reduced hematopoietic stem cell (HSC) numbers and impaired regeneration in bone marrow due to apoptotic destruction of SNS fibers and/or endothelial cells. Furthermore, pharmacological elevation of NPY prevented bone marrow impairments in a mouse model of chemotherapy-induced SNS injury, while NPY injection into conditional knockout mice lacking the Y1 receptor in macrophages did not relieve bone marrow dysfunction. These results indicate that NPY promotes neuroprotection and restores bone marrow dysfunction from chemotherapy-induced SNS injury through the Y1 receptor in macrophages. They also reveal a new role of NPY as a regulator of the bone marrow microenvironment and highlight the potential therapeutic value of this neuropeptide.
C1 [Park, Min Hee; Jin, Hee Kyung; Bae, Jae-sung] Kyungpook Natl Univ, Stem Cell Neuroplast Res Grp, Daegu, South Korea.
   [Park, Min Hee; Bae, Jae-sung] Kyungpook Natl Univ, Sch Med, Cell & Matrix Res Inst, Dept Physiol, Daegu, South Korea.
   [Park, Min Hee; Bae, Jae-sung] Kyungpook Natl Univ, Dept Biomed Sci, Plus KNU Biomed Convergence Program BK21, Daegu, South Korea.
   [Jin, Hee Kyung] Kyungpook Natl Univ, Coll Vet Med, Dept Lab Anim Med, Daegu, South Korea.
   [Min, Woo-Kie] Kyungpook Natl Univ Hosp, Dept Orthopaed Surg, Daegu, South Korea.
   [Lee, Won Woo] Seoul Natl Univ, Coll Med, Dept Microbiol & Immunol, Seoul, South Korea.
   [Lee, Jeong Eun] Kyungpook Natl Univ Hosp, Dept Radiat Oncol, Daegu, South Korea.
   [Akiyama, Haruhiko] Kyoto Univ, Dept Orthopaed, Kyoto, Japan.
   [Herzog, Herbert] Garvan Inst Med Res, Neurosci Res Program, Sydney, NSW, Australia.
   [Enikolopov, Grigori N.] Cold Spring Harbor Lab, Cold Spring Harbor, NY 11724 USA.
   [Schuchman, Edward H.] Icahn Sch Med Mt Sinai, Dept Genet & Genom Sci, New York, NY 10029 USA.
C3 Kyungpook National University (KNU); Kyungpook National University
   (KNU); Kyungpook National University (KNU); Kyungpook National
   University (KNU); Kyungpook National University (KNU); Kyungpook
   National University Hospital (KNUH); Seoul National University (SNU);
   Kyungpook National University (KNU); Kyungpook National University
   Hospital (KNUH); Kyoto University; Garvan Institute of Medical Research;
   Cold Spring Harbor Laboratory; Icahn School of Medicine at Mount Sinai
RP Bae, JS (corresponding author), Kyungpook Natl Univ, Stem Cell Neuroplast Res Grp, Daegu, South Korea.
EM jsbae@knu.ac.kr
RI Herzog, Herbert/B-8294-2008; Lee, Won-Woo/J-5588-2012; Bae,
   Jae-sung/AAM-8663-2021; Kim, Young/T-8521-2019; Enikolopov,
   Grigori/B-7771-2009
OI Herzog, Herbert/0000-0002-1713-1029; Lee, Won-Woo/0000-0002-5347-9591;
   Min, Woo-Kie/0000-0003-2079-5085; Enikolopov,
   Grigori/0000-0001-8178-8917
FU Bio & Medical Technology Development Program [2012M3A9C6049913]; Basic
   Science Research Program of the National Research Foundation of Korea
   (NRF) - Ministry of Science, ICT & Future Planning, Republic of Korea
   [2014R1A2A1A10051107]; Korea Health Technology R&D Project through the
   Korea Health Industry Development Institute (KHIDI) - Ministry of Health
   & Welfare, Republic of Korea [HI14C1636]
FX This work was supported by the Bio & Medical Technology Development
   Program (2012M3A9C6049913) and Basic Science Research Program
   (2014R1A2A1A10051107) of the National Research Foundation of Korea (NRF)
   funded by the Ministry of Science, ICT & Future Planning, Republic of
   Korea. This research was also supported by a grant of the Korea Health
   Technology R&D Project through the Korea Health Industry Development
   Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic
   of Korea (HI14C1636).
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NR 46
TC 50
Z9 60
U1 0
U2 16
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0261-4189
EI 1460-2075
J9 EMBO J
JI Embo J.
PD JUN 12
PY 2015
VL 34
IS 12
BP 1648
EP 1660
DI 10.15252/embj.201490174
PG 13
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA CK4DN
UT WOS:000356171300007
PM 25916827
OA Green Published
DA 2025-06-11
ER

PT J
AU Sindhu, S
   Leung, YH
   Arefanian, H
   Madiraju, SRM
   Al-Mulla, F
   Ahmad, R
   Prentki, M
AF Sindhu, Sardar
   Leung, Yat Hei
   Arefanian, Hossein
   Madiraju, S. R. Murthy
   Al-Mulla, Fahd
   Ahmad, Rasheed
   Prentki, Marc
TI Neutral sphingomyelinase-2 and cardiometabolic diseases
SO OBESITY REVIEWS
LA English
DT Article
DE cardiometabolic diseases; ceramide; nSMase2; sphingolipid
ID NECROSIS-FACTOR-ALPHA; PROTEIN-KINASE-B; LOW-DENSITY LIPOPROTEIN;
   BETA-CELL FAILURE; SPHINGOLIPID METABOLISM; INSULIN-RESISTANCE;
   OXIDATIVE STRESS; SKELETAL-MUSCLE; CARDIOVASCULAR TISSUES; CERAMIDE
   METABOLISM
AB Sphingolipids, in particular ceramides, play vital role in pathophysiological processes linked to metabolic syndrome, with implications in the development of insulin resistance, pancreatic ss-cell dysfunction, type 2 diabetes, atherosclerosis, inflammation, nonalcoholic steatohepatitis, and cancer. Ceramides are produced by the hydrolysis of sphingomyelin, catalyzed by different sphingomyelinases, including neutral sphingomyelinase 2 (nSMase2), whose dysregulation appears to underlie many of the inflammation-related pathologies. In this review, we discuss the current knowledge on the biochemistry of nSMase2 and ceramide production and its regulation by inflammatory cytokines, with particular reference to cardiometabolic diseases. nSMase2 contribution to pathogenic processes appears to involve cyclical feed-forward interaction with proinflammatory cytokines, such as TNF-alpha and IL-1ss, which activate nSMase2 and the production of ceramides, that in turn triggers the synthesis and release of inflammatory cytokines. We elaborate these pathogenic interactions at the molecular level and discuss the potential therapeutic benefits of inhibiting nSMase2 against inflammation-driven cardiometabolic diseases.
C1 [Sindhu, Sardar] Dasman Diabet Inst, Anim & Imaging Core Facil, Dasman, Kuwait.
   [Leung, Yat Hei; Madiraju, S. R. Murthy; Prentki, Marc] Univ Montreal, Dept Nutr, Montreal, PQ, Canada.
   [Leung, Yat Hei; Madiraju, S. R. Murthy; Prentki, Marc] Univ Montreal, Dept Biochem & Mol Med, Montreal, PQ, Canada.
   [Leung, Yat Hei; Madiraju, S. R. Murthy; Prentki, Marc] Ctr Rech Ctr Hosp Univ Montreal CRCHUM, Montreal Diabet Res Ctr, Montreal, PQ, Canada.
   [Arefanian, Hossein; Ahmad, Rasheed] Dasman Diabet Inst, Immunol & Microbiol Dept, Dasman 15462, Kuwait.
   [Al-Mulla, Fahd] Dasman Diabet Inst, Dept Genet & Bioinformat, Dasman, Kuwait.
C3 Dasman Diabetes Institute (DDI); Universite de Montreal; Universite de
   Montreal; Universite de Montreal; Dasman Diabetes Institute (DDI);
   Dasman Diabetes Institute (DDI)
RP Ahmad, R (corresponding author), Dasman Diabet Inst, Immunol & Microbiol Dept, Dasman 15462, Kuwait.; Prentki, M (corresponding author), Univ Montreal, Nutr Biochem & Mol Med, Room R08-412,900 Rue St Denis, Montreal, PQ H2X 0A9, Canada.; Prentki, M (corresponding author), CRCHUM, Montreal Diabet Res Ctr, Room R08-412,900 Rue St Denis, Montreal, PQ H2X 0A9, Canada.
EM rasheed.ahmad@dasmaninstitute.org; marc.prentki@umontreal.ca
RI sindhu, sardar/ABE-3565-2021; Ahmad, Rasheed/LMP-1937-2024; Arefanian,
   Hossein/K-2422-2019; Prentki, Marc/LBI-2401-2024; Al-Mulla,
   Fahd/E-2068-2015
OI Al-Mulla, Fahd/0000-0001-5409-3829; Arefanian,
   Hossein/0000-0001-6414-0916
FU Canadian Institutes of Health Research; Montreal Medical
   International/Dasman Diabetes Institute
FX Canadian Institutes of Health Research; Montreal Medical
   International/Dasman Diabetes Institute
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NR 226
TC 22
Z9 24
U1 0
U2 17
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1467-7881
EI 1467-789X
J9 OBES REV
JI Obes. Rev.
PD AUG
PY 2021
VL 22
IS 8
AR e13248
DI 10.1111/obr.13248
EA MAR 2021
PG 16
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA TH1KO
UT WOS:000630372600001
PM 33738905
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Zendedel, E
   Butler, AE
   Atkin, SL
   Sahebkar, A
AF Zendedel, Elham
   Butler, Alexandra E.
   Atkin, Stephen L.
   Sahebkar, Amirhossein
TI Impact of curcumin on sirtuins: A review
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Article
DE cancer; curcumin; sirtuin-1 (SIRT1); sirtuin
ID SYSTEMIC OXIDATIVE STRESS; REGULATOR 1 PROTECTS; FATTY LIVER-DISEASE;
   NF-KAPPA-B; MITOCHONDRIAL DYSFUNCTION; PIPERINE COMBINATION;
   CLINICAL-PRACTICE; GLUCOSE-HOMEOSTASIS; HISTONE DEACETYLASE; METABOLIC
   SYNDROME
AB Curcumin is a bioactive phytochemical that modulates several physiological and cellular processes leading to therapeutic effects against different diseases. Sirtuins are highly conserved nicotine adenine dinucleotide-dependent proteins that regulate the activity of target enzymes and transcription factors by deacetylation. Curcumin possesses both antioxidant and anti-inflammatory properties and has been shown to increase sirtuin-1 (SIRT1) by activating small molecules. Upregulation of SIRT1 by curcumin has been reported to confer protective effects against a range of neurological disorders including glutamate excitotoxicity, beta-amyloid-induced cell death in cortical neurons, cerebral ischemic damage, and stroke. Activation of AMPK and SIRT1 by curcumin has also been noted to mediate the protective effects of curcumin against ischemia/reperfusion injury, cardiac fibrosis, diabetes, and lipid metabolism abnormalities. These protective effects of SIRT1 activation are partly mediated by the deacetylation of p53 and reduction of apoptosis. In this review, we summarize the role of SIRT1 in mediating the pharmacological effects of curcumin in several diseases.
C1 [Zendedel, Elham] Islamic Azad Univ, Dept Biol, Fac Sci, Mashhad Branch, Mashhad, Iran.
   [Butler, Alexandra E.] Antidoping Lab Qatar, Life Sci Res Div, Doha, Qatar.
   [Atkin, Stephen L.] Weill Cornell Med Qatar, Doha, Qatar.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Neurogen Inflammat Res Ctr, Mashhad, Iran.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Biotechnol Res Ctr, Pharmaceut Technol Inst, Mashhad, Iran.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Sch Pharm, Mashhad, Iran.
C3 Islamic Azad University; Anti Doping Laboratory (Qatar); Qatar
   Foundation (QF); Weill Cornell Medical College Qatar; Mashhad University
   of Medical Sciences; Mashhad University of Medical Sciences; Mashhad
   University of Medical Sciences
RP Sahebkar, A (corresponding author), Mashhad Univ Med Sci, Biotechnol Res Ctr, Mashhad 9177948564, Iran.
EM sahebkara@mums.ac.ir
RI Sahebkar, Amirhossein/B-5124-2018; Atkin, stephen/ABE-7047-2020;
   Zendedel, Elham/AAB-4369-2020
OI Butler, Alexandra/0000-0002-5762-3917
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NR 116
TC 42
Z9 49
U1 0
U2 25
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0730-2312
EI 1097-4644
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PD DEC
PY 2018
VL 119
IS 12
BP 10291
EP 10300
DI 10.1002/jcb.27371
PG 10
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA HA3DO
UT WOS:000450130500063
PM 30145851
DA 2025-06-11
ER

PT J
AU Montgomery, MK
   Turner, N
AF Montgomery, Magdalene K.
   Turner, Nigel
TI Mitochondrial dysfunction and insulin resistance: an update
SO ENDOCRINE CONNECTIONS
LA English
DT Review
DE mitochondrial function; insulin resistance; lipid accumulation;
   oxidative stress; mitophagy; mitochondrial dynamics
ID HUMAN SKELETAL-MUSCLE; ACTIVATED PROTEIN-KINASE; FATTY-ACID OXIDATION;
   OXYGEN SPECIES PRODUCTION; ACETYL-COA CARBOXYLASE-2; RESPIRATORY
   COMPLEX-I; WEIGHT-LOSS; ENERGY-EXPENDITURE; METABOLIC SYNDROME;
   NONDIABETIC SUBJECTS
AB Mitochondrial dysfunction has been implicated in the development of insulin resistance (IR); however, a large variety of association and intervention studies as well as genetic manipulations in rodents have reported contrasting results. Indeed, even 39 years after the first publication describing a relationship between IR and diminished mitochondrial function, it is still unclear whether a direct relationship exists, and more importantly if changes in mitochondrial capacity are a cause or consequence of IR. This review will take a journey through the past and summarise the debate about the occurrence of mitochondrial dysfunction and its possible role in causing decreased insulin action in obesity and type 2 diabetes. Evidence is presented from studies in various human populations, as well as rodents with genetic manipulations of pathways known to affect mitochondrial function and insulin action. Finally, we have discussed whether mitochondria are a potential target for the treatment of IR.
C1 [Montgomery, Magdalene K.; Turner, Nigel] Univ New South Wales, Sch Med Sci, UNSW Med, Dept Pharmacol, Sydney, NSW 2052, Australia.
C3 University of New South Wales Sydney
RP Montgomery, MK (corresponding author), Univ New South Wales, Sch Med Sci, UNSW Med, Dept Pharmacol, Sydney, NSW 2052, Australia.
EM m.montgomery@unsw.edu.au
RI ; Turner, Nigel/H-7176-2013
OI Montgomery, Magdalene/0000-0003-2551-4174; Turner,
   Nigel/0000-0002-0119-9328
FU National Health and Medical Research Council of Australia (NHMRC); NHMRC
   [APP1071143]; Australian Research Council [FT120100371]; Australian
   Research Council [FT120100371] Funding Source: Australian Research
   Council
FX Work in the laboratory of the authors is supported by the National
   Health and Medical Research Council of Australia (NHMRC). M K Montgomery
   is supported by a NHMRC Early Career Fellowship (APP1071143) and N
   Turner by an Australian Research Council Future Fellowship
   (FT120100371).
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NR 139
TC 397
Z9 448
U1 4
U2 56
PU BIOSCIENTIFICA LTD
PI BRISTOL
PA EURO HOUSE, 22 APEX COURT WOODLANDS, BRADLEY STOKE, BRISTOL BS32 4JT,
   ENGLAND
EI 2049-3614
J9 ENDOCR CONNECT
JI Endocr. Connect.
PD MAR 1
PY 2015
VL 4
IS 1
DI 10.1530/EC-14-0092
PG 15
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA DV9LD
UT WOS:000383261100001
PM 25385852
OA Green Published, Green Submitted
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Grouzmann, E
   Lamine, F
AF Grouzmann, Eric
   Lamine, Faiza
TI Determination of catecholamines in plasma and urine
SO BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Article
DE catecholamines; norepinephrine; epinephrine; dopamine; metanephrines;
   pheochromocytoma; neuroblastoma
ID SYMPATHETIC NERVOUS ACTIVITY; TANDEM MASS-SPECTROMETRY;
   LIQUID-CHROMATOGRAPHY; ELECTROCHEMICAL DETECTION; BIOCHEMICAL-DIAGNOSIS;
   FRACTIONATED METANEPHRINES; METABOLIC SYNDROME; BLOOD-PRESSURE;
   PHEOCHROMOCYTOMA; DOPAMINE
AB For more than 20 years, measurement of catecholamines in plasma and urine in clinical chemistry laboratories has been the cornerstone of the diagnosis of neuroendocrine tumors deriving from the neural crest such as pheochromocytoma (PHEO) and neuroblastoma (NB), and is still used to assess sympathetic stress function in man and, animals. Although assay of catecholamines in urine are still considered the biochemical standard for the diagnosis of NB, they have been progressively abandoned for excluding/confirming PHEOs to the advantage of metanephrines (MNs). Nevertheless, catecholamine determinations are still of interest to improve the biochemical diagnosis of PHEO in difficult cases that usually require a clonidine-suppression test, or to establish whether a patient with PHEO secretes high concentrations of catecholamines in addition to metanephrines.
   The aim of this chapter is to provide an update about the catecholamine assays in plasma and urine and to show the most common pre-analytical and analytical pitfalls associated with their determination. (C) 2013 Elsevier Ltd. All rights reserved.
C1 [Grouzmann, Eric] Univ Lausanne Hosp, Serv Biomed, Lab Catecholamines & Peptides, CH-1011 Lausanne, Switzerland.
   [Lamine, Faiza] La Rabta Univ Hosp, Dept Endocrinol & Diabet, Tunis, Tunisia.
C3 University of Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV);
   Universite de Tunis-El-Manar; Hopital La Rabta
RP Grouzmann, E (corresponding author), Lausanne Univ Hosp CHUV Lausanne, Serv Biomed, CH-1011 Lausanne, Switzerland.
EM Eric.grouzmann@chuv.ch
CR [Anonymous], 1999, NIH PUBLICATION
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NR 87
TC 61
Z9 66
U1 2
U2 81
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1521-690X
EI 1532-1908
J9 BEST PRACT RES CL EN
JI Best Pract. Res. Clin. Endoc. Metab.
PD OCT
PY 2013
VL 27
IS 5
BP 713
EP 723
DI 10.1016/j.beem.2013.06.004
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 243KE
UT WOS:000326314500008
PM 24094641
DA 2025-06-11
ER

PT J
AU Batitucci, G
   Abud, GF
   Ortiz, GU
   Belisário, LF
   Travieso, SG
   Viliod, MCD
   Venturini, ACR
   de Freitas, EC
AF Batitucci, Gabriela
   Abud, Gabriela Ferreira
   Ortiz, Gabriela Ueta
   Belisario, Lucas Fernandes
   Travieso, Sofia Germano
   Viliod, Marcela Coffacci de Lima
   Venturini, Ana Claudia Rossini
   de Freitas, Ellen Cristini
TI Sarcobesity: New paradigms for healthy aging related to taurine
   supplementation, gut microbiota and exercise
SO AGEING RESEARCH REVIEWS
LA English
DT Article
DE Sarcobesity; Aging; Taurine; Gut microbiota; Physical exercise;
   Therapeutic targets
ID SARCOPENIC OBESITY; ADIPOSE-TISSUE; SKELETAL-MUSCLE; BODY-COMPOSITION;
   OLDER-ADULTS; RESISTANCE EXERCISE; DIETARY-SUPPLEMENTS; METABOLIC
   SYNDROME; MUSCULAR STRENGTH; TELOMERE LENGTH
AB Enigmatic sarcopenic obesity is still a challenge for science and adds to the global public health burden. The progressive accumulation of body fat combined with a dysfunctional skeletal muscle structure and composition, oxidative stress, mitochondrial dysfunction, and anabolic resistance, among other aggravating factors, together represent the seriousness and complexity of treating the metabolic disorder of sarcobesity in aging. For this reason, further studies are needed that encourage the support of therapeutic management. It is along these lines that we direct the reader to therapeutic approaches that demonstrate important, but still obscure, outcomes in the physiological conditions of sarcobesity, such as the role of taurine in modulating inflammatory and antioxidant mechanisms in muscle and adipose tissue, as well as the management of gut microbiota, able to systemically re-establish the structure and function of the gut-muscle axis, in addition to the merits of physical exercise as an instrument to improve muscular health and lifestyle quality.
C1 [Batitucci, Gabriela] Univ Estadual Campinas, UNICAMP, Obes & Comorbid Res Ctr, Sch Med Sci, Campinas, SP, Brazil.
   [Abud, Gabriela Ferreira; Ortiz, Gabriela Ueta; Travieso, Sofia Germano; de Freitas, Ellen Cristini] Univ Sao Paulo, USP, FMRP, Ribeirao Preto Med Sch,Dept Hlth Sci, Ribeirao Preto, SP, Brazil.
   [Belisario, Lucas Fernandes; Viliod, Marcela Coffacci de Lima; Venturini, Ana Claudia Rossini; de Freitas, Ellen Cristini] Univ Sao Paulo, Sch Phys Educ & Sports Ribeirao Preto, Lab Exercise Physiol & Metab, EEFERP,USP, Ribeirao Preto, Brazil.
C3 Universidade Estadual de Campinas; Universidade de Sao Paulo;
   Universidade de Sao Paulo
RP de Freitas, EC (corresponding author), Univ Sao Paulo, USP, EEFERP, Sch Phys Educ & Sports Ribeirao Preto, Bandeirantes Ave 3900, Ribeirao Preto, SP, Brazil.
EM ellenfreitas@usp.br
RI Ortiz, Gabriela/ABF-5173-2021; Rossini-Venturini, Ana
   Claudia/HMP-2328-2023; Freitas, Ellen/C-4497-2012; Abud,
   Gabriela/AAB-6197-2022
FU Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (Fapesp)
   [2019/17947-7, 2019/11820-5, 2022/15078-4, 2022/00221-6, 2022/06638-6,
   2023/09554-0, 2023/01611-5, 2024/01271-2]; National Council for
   Scientific and Technological Development, CNPq [303766/2022-0]
FX This research was funded by Fundacao de Amparo a Pesquisa do Estado de
   Sao Paulo (Fapesp), grant numbers 2019/17947-7, 2019/11820-5,
   2022/15078-4, 2022/00221-6, 2022/06638-6, 2023/09554-0, 2023/01611-5,
   2024/01271-2 and National Council for Scientific and Technological
   Development, CNPq number 303766/2022-0.
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NR 182
TC 1
Z9 1
U1 17
U2 23
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 1568-1637
EI 1872-9649
J9 AGEING RES REV
JI Ageing Res. Rev.
PD NOV
PY 2024
VL 101
AR 102460
DI 10.1016/j.arr.2024.102460
EA SEP 2024
PG 16
WC Cell Biology; Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Geriatrics & Gerontology
GA G9L8P
UT WOS:001319777800001
PM 39173917
DA 2025-06-11
ER

PT J
AU Lesmana, R
   Tandean, S
   Christoper, A
   Suwantika, AA
   Wathoni, N
   Abdulah, R
   Fearnley, J
   Bankova, V
   Zulhendri, F
AF Lesmana, R.
   Tandean, S.
   Christoper, A.
   Suwantika, A. A.
   Wathoni, N.
   Abdulah, R.
   Fearnley, J.
   Bankova, V.
   Zulhendri, F.
TI Propolis as an autophagy modulator in relation to its roles in redox
   balance and inflammation regulation
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Review
DE Propolis; Functional food; Nutraceutical; Autophagy; Antioxidant;
   Pro-oxidant; Anti-inflammatory
ID OXIDATIVE STRESS; PROOXIDANT ACTIVITY; UP-REGULATION; DNA-DAMAGE;
   ACTIVATION; NRF2; DEGRADATION; POLYPHENOLS; INHIBITION; APOPTOSIS
AB Autophagy is a degradation process that is evolutionarily conserved and is essential in maintaining cellular and physiological homeostasis through lysosomal removal and elimination of damaged peptides, proteins and cellular organelles. The dysregulation of autophagy is implicated in various diseases and disorders, including cancers, infection-related, and metabolic syndrome-related diseases. Propolis has been demonstrated in various studies including many human clinical trials to have antimicrobial, antioxidant, anti-inflammatory, immunemodulator, neuro-protective, and anti -cancer. Nevertheless, the autophagy modulation properties of propolis have not been extensively studied and explored. The role of propolis and its bioactive compounds in modulating cellular autophagy is possibly due to their dual role in redox balance and inflammation. The present review attempts to discuss the activities of propolis as an autophagy modulator in biological models in relation to various diseases/disorders which has implications in the development of propolis-based nutraceuticals, functional foods, and complementary therapies.
C1 [Lesmana, R.] Univ Padjadjaran, Fac Med, Dept Biomed Sci, Physiol Div, Bandung, Indonesia.
   [Lesmana, R.] Univ Padjadjaran, Biol Act Div, Cent Lab, Bandung, Indonesia.
   [Tandean, S.] Univ Sumatera Utara, Fac Med, Dept Neurosurg, Medan 20222, Sumatera Utara, Indonesia.
   [Christoper, A.] Univ Padjadjaran, Fac Med, Postgrad Program Med Sci, Bandung 45363, Indonesia.
   [Suwantika, A. A.; Abdulah, R.] Univ Padjadjaran, Ctr Excellence Higher Educ Pharmaceut Care Innovat, Bandung 45363, Indonesia.
   [Suwantika, A. A.; Abdulah, R.] Univ Padjadjaran, Fac Pharm, Dept Pharmacol & Clin Pharm, Bandung 45363, Indonesia.
   [Wathoni, N.] Univ Padjadjaran, Fac Pharm, Dept Pharmaceut & Pharmaceut Technol, Sumedang 45363, Indonesia.
   [Wathoni, N.] Res Ctr Biopolymers Drug & Cosmet Delivery, Bandung 45363, Indonesia.
   [Fearnley, J.] Apiceut Res Ctr, Unit 3b Enterprise Way, Whitby YO18 7NA, N Yorkshire, England.
   [Bankova, V.] Bulgarian Acad Sci, Inst Organ Chem, Ctr Phytochem, Acad G Bonchev str,Bl 9, Sofia 1113, Bulgaria.
   [Zulhendri, F.] Kebun Efi, Kabanjahe 22171, North Sumatra, Indonesia.
   [Zulhendri, F.] Univ Padjadjaran, Ctr Excellence Higher Educ Pharmaceut Care Innovat, Bandung, Indonesia.
C3 Universitas Padjadjaran; Universitas Padjadjaran; University of North
   Sumatra; Universitas Padjadjaran; Universitas Padjadjaran; Universitas
   Padjadjaran; Universitas Padjadjaran; Bulgarian Academy of Sciences;
   Universitas Padjadjaran
RP Zulhendri, F (corresponding author), Kebun Efi, Kabanjahe 22171, North Sumatra, Indonesia.
EM ronny@unpad.ac.id; steven.tandean@usu.ac.id;
   andreas21008@mail.unpad.ac.id; auliya@unpad.ac.id; nasrul@unpad.ac.id;
   r.abdulah@unpad.ac.id; james.fearnley@beearc.com; Bankova@orgchm.bas.bg;
   felix.zulhendri@kebunefi.com
RI Suwantika, Auliya/ABF-5700-2020; Bankova, Vassya/A-8972-2010; Tandean,
   Steven/AAZ-9237-2021; Wathoni, Nasrul/F-6372-2012
OI Christoper, Andreas/0000-0001-7300-4262
FU Universitas Padjajaran
FX This research received no external funding. Universitas Padjajaran
   funded the APC.
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NR 123
TC 6
Z9 6
U1 2
U2 5
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD JUN
PY 2024
VL 175
AR 116745
DI 10.1016/j.biopha.2024.116745
EA MAY 2024
PG 12
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA TS7V9
UT WOS:001243323400001
PM 38761422
OA gold
DA 2025-06-11
ER

PT J
AU Capece, U
   Moffa, S
   Improta, I
   Di Giuseppe, G
   Nista, EC
   Cefalo, CMA
   Cinti, F
   Pontecorvi, A
   Gasbarrini, A
   Giaccari, A
   Mezza, T
AF Capece, Umberto
   Moffa, Simona
   Improta, Ilaria
   Di Giuseppe, Gianfranco
   Nista, Enrico Celestino
   Cefalo, Chiara M. A.
   Cinti, Francesca
   Pontecorvi, Alfredo
   Gasbarrini, Antonio
   Giaccari, Andrea
   Mezza, Teresa
TI Alpha-Lipoic Acid and Glucose Metabolism: A Comprehensive Update on
   Biochemical and Therapeutic Features
SO NUTRIENTS
LA English
DT Review
DE alpha-lipoic; glucose metabolism; diabetes prevention; complications
ID INSULIN-AUTOIMMUNE-SYNDROME; POLYCYSTIC-OVARY-SYNDROME; ACTIVATED
   PROTEIN-KINASE; TYPE-2 DIABETES-MELLITUS; SYNDROME HIRATA-DISEASE;
   D-CHIRO-INOSITOL; OXIDATIVE STRESS; AUTONOMIC NEUROPATHY; HEPATIC
   INFLAMMATION; SKELETAL-MUSCLE
AB Alpha-lipoic acid (ALA) is a natural compound with antioxidant and pro-oxidant properties which has effects on the regulation of insulin sensitivity and insulin secretion. ALA is widely prescribed in patients with diabetic polyneuropathy due to its positive effects on nerve conduction and alleviation of symptoms. It is, moreover, also prescribed in other insulin resistance conditions such as metabolic syndrome (SM), polycystic ovary syndrome (PCOS) and obesity. However, several cases of Insulin Autoimmune Syndrome (IAS) have been reported in subjects taking ALA. The aim of the present review is to describe the main chemical and biological functions of ALA in glucose metabolism, focusing on its antioxidant activity, its role in modulating insulin sensitivity and secretion and in symptomatic peripheral diabetic polyneuropathy. We also provide a potential explanation for increased risk for the development of IAS.
C1 [Capece, Umberto; Moffa, Simona; Improta, Ilaria; Di Giuseppe, Gianfranco; Cefalo, Chiara M. A.; Cinti, Francesca; Pontecorvi, Alfredo; Giaccari, Andrea] Fdn Policlin Univ Agostino Gemelli IRCCS, Endocrinol & Diabetol Unit, I-00168 Rome, Italy.
   [Capece, Umberto; Moffa, Simona; Improta, Ilaria; Di Giuseppe, Gianfranco; Nista, Enrico Celestino; Cefalo, Chiara M. A.; Cinti, Francesca; Pontecorvi, Alfredo; Gasbarrini, Antonio; Giaccari, Andrea; Mezza, Teresa] Univ Cattolica Sacro Cuore, Dept Translat Med & Surg, I-00168 Rome, Italy.
   [Nista, Enrico Celestino; Gasbarrini, Antonio; Mezza, Teresa] Fdn Policlin Univ Agostino Gemelli IRCCS, Digest Dis Ctr, I-00168 Rome, Italy.
C3 Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli;
   Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli;
   Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli
RP Giaccari, A (corresponding author), Fdn Policlin Univ Agostino Gemelli IRCCS, Endocrinol & Diabetol Unit, I-00168 Rome, Italy.; Giaccari, A (corresponding author), Univ Cattolica Sacro Cuore, Dept Translat Med & Surg, I-00168 Rome, Italy.
EM andrea.giaccari@unicatt.it
RI Gasbarrini, Antonio/AAB-8487-2019; Di Giuseppe,
   Gianfranco/LGY-8829-2024; Giaccari, Andrea/ACI-3719-2022; Cefalo, Chiara
   Maria Assunta/AAA-3429-2022; mezza, teresa/B-1856-2014; Pontecorvi,
   Alfredo/K-5146-2016; Cinti, Francesca/AAY-5534-2021
OI Capece, Umberto/0000-0001-8048-8664; Cinti,
   Francesca/0000-0001-5170-7055; Cefalo, Chiara Maria
   Assunta/0000-0002-8665-8406; Di Giuseppe,
   Gianfranco/0000-0003-4506-5193; PONTECORVI, Alfredo/0000-0003-0570-6865;
   Gasbarrini, Antonio/0000-0002-6230-1779
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NR 137
TC 36
Z9 38
U1 3
U2 23
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JAN
PY 2023
VL 15
IS 1
AR 18
DI 10.3390/nu15010018
PG 19
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 7P6KS
UT WOS:000908812500001
PM 36615676
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Che, WS
   Zhao, M
   Li, XQ
   Li, CL
   Cho, WC
   Yu, S
AF Che, Wensheng
   Zhao, Ming
   Li, Xiaoqing
   Li, Chunlong
   Cho, William C.
   Yu, Shan
TI Current insights in molecular characterization of non-alcoholic fatty
   liver disease and treatment
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Review
DE non-alcoholic fatty liver disease (NAFLD); non-alcoholic steatohepatitis
   (NASH); gut microbiota; metabolic diseases; adenosine
   monophosphate-activated protein kinase
ID ACTIVATED PROTEIN-KINASE; GUT MICROBIOTA; INSULIN-RESISTANCE; HEPATIC
   STEATOSIS; OXIDATIVE STRESS; CONTROLLED-TRIAL; GENE-EXPRESSION; ENERGY
   SENSOR; AMPK ACTIVITY; STEATOHEPATITIS
AB There is a continuously rising incidence of non-alcoholic fatty liver disease (NAFLD) around the world, which parallels the increasing incidence of metabolic diseases. NAFLD is a range of liver conditions that contains simple non-alcoholic fatty liver and advanced non-alcoholic steatohepatitis. In serious cases, NAFLD may develop into cirrhosis or even liver cancer. NAFLD has an intense relationship with metabolic syndrome, type 2 diabetes mellitus. It is known that gut microbiota, and functional molecules such as adenosine monophosphate-activated protein kinase JNK, and peroxisome proliferator-activated receptors (PPARs) in progressing and treating NAFLD. Traditionally, the conventional and effective therapeutic strategy is lifestyle intervention. Nowadays, new medicines targeting specific molecules, such as farnesoid X receptor, PPARs, and GLP-1 receptor, have been discovered and shown beneficial effects on patients with NAFLD. In this article, we focus on the molecular mechanisms and therapeutic approaches to NAFLD.
C1 [Che, Wensheng; Li, Chunlong] Harbin Med Univ, Affiliated Hosp 2, Dept Gen Surg, Harbin, Peoples R China.
   [Zhao, Ming] Chengdu Med Coll, Chengdu, Peoples R China.
   [Zhao, Ming] Chengdu Med Coll, Affiliated Hosp 1, Dept Gastroenterol, Chengdu, Peoples R China.
   [Li, Xiaoqing; Yu, Shan] Harbin Med Univ, Affiliated Hosp 2, Dept Pathol, Harbin, Peoples R China.
   [Cho, William C.] Queen Elizabeth Hosp, Dept Clin Oncol, Kowloon, Hong Kong, Peoples R China.
C3 Harbin Medical University; Chengdu Medical College; Chengdu Medical
   College; Harbin Medical University
RP Li, CL (corresponding author), Harbin Med Univ, Affiliated Hosp 2, Dept Gen Surg, Harbin, Peoples R China.; Yu, S (corresponding author), Harbin Med Univ, Affiliated Hosp 2, Dept Pathol, Harbin, Peoples R China.; Cho, WC (corresponding author), Queen Elizabeth Hosp, Dept Clin Oncol, Kowloon, Hong Kong, Peoples R China.
EM chunlong81@163.com; williamcscho@gmail.com; yushan@hrbmu.edu.cn
RI Chunlong, Li/AAM-8644-2021; Cho, William/H-7429-2019
FU Postdoctoral Scientific Research Developmental Fund;  [LBH-Q20112]
FX Funding Funding was provided by the Postdoctoral Scientific Research
   Developmental Fund (No. LBH-Q20112) of Heilongjiang.
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NR 155
TC 3
Z9 3
U1 5
U2 15
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD NOV 29
PY 2022
VL 13
AR 1002916
DI 10.3389/fendo.2022.1002916
PG 16
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 6Y0IK
UT WOS:000896788300001
PM 36523601
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Sobhani, Z
   Mohtashami, L
   Amiri, MS
   Ramezani, M
   Emami, SA
   Simal-Gandara, J
AF Sobhani, Zahra
   Mohtashami, Leila
   Amiri, Mohammad Sadegh
   Ramezani, Mahin
   Emami, Seyed Ahmad
   Simal-Gandara, Jesus
TI Ethnobotanical and phytochemical aspects of the edible herb
   Coriandrum sativum L.
SO JOURNAL OF FOOD SCIENCE
LA English
DT Review
DE Apiaceae; coriander; Coriandrum sativum; functional foods; traditional
   medicine
ID ESSENTIAL OIL COMPOSITION; PENTYLENETETRAZOLE-INDUCED SEIZURES;
   OXIDATIVE STRESS; MEDICINAL-PLANTS; IN-VITRO; NEURODEGENERATIVE
   DISEASES; HYDROALCOHOLIC EXTRACT; ANTIOXIDANT ACTIVITIES;
   CHEMICAL-COMPOSITION; ANTIBIOFILM ACTIVITY
AB Coriandrum sativum (coriander) is an edible herb in the family Apiaceae. The leaves, fruits, and stems of C. sativum have long been used as culinary spice due to their favorable odor. Traditional practitioners used this plant for treating different diseases like blepharitis, scabies, aphthous stomatitis, laryngitis, headache, and palpitation. In modern researches, coriander has demonstrated anxiolytic, anticonvulsant, antimigraine, neuroprotective, analgesic, diuretic, hypoglycemic, hypolipidemic, hypotensive, anticancer, and antioxidant activities. Coriander contains a wide range of bioactive phytochemicals among which phenylpropenes, terpenoids, isocoumarins, phytosterols, and fatty acids are the most important. This review provides information about the botanical and ethnobotanical aspects, chemical profile, therapeutic uses in Islamic traditional medicine (ITM), and recent pharmacological studies of coriander effects. The results have shown that coriander and its monoterpenoid compound, linalool, can be considered as potential drug candidates for treating metabolic syndrome and different inflammatory conditions especially neural and CNS diseases.
C1 [Sobhani, Zahra; Emami, Seyed Ahmad] Mashhad Univ Med Sci, Sch Pharm, Dept Tradit Pharm, Mashhad, Iran.
   [Mohtashami, Leila] Mashhad Univ Med Sci, Sch Pharm, Dept Pharmacognosy, Mashhad, Razavi Khorasan, Iran.
   [Amiri, Mohammad Sadegh] Payame Noor Univ, Dept Biol, Tehran, Iran.
   [Ramezani, Mahin] Mashhad Univ Med Sci, Nanotechnol Res Ctr, Mashhad, Razavi Khorasan, Iran.
   [Ramezani, Mahin] Mashhad Univ Med Sci, Pharmaceut Res Ctr, Mashhad, Razavi Khorasan, Iran.
   [Simal-Gandara, Jesus] Univ Vigo, Dept Analyt Chem & Food Sci, Nutr & Bromatol Grp, Fac Food Sci & Technol, Ourense Campus, E-32004 Orense, Spain.
C3 Mashhad University of Medical Sciences; Mashhad University of Medical
   Sciences; Payame Noor University; Mashhad University of Medical
   Sciences; Mashhad University of Medical Sciences; Universidade de Vigo
RP Emami, SA (corresponding author), Mashhad Univ Med Sci, Sch Pharm, Dept Tradit Pharm, Mashhad, Iran.; Simal-Gandara, J (corresponding author), Univ Vigo, Dept Analyt Chem & Food Sci, Nutr & Bromatol Grp, Fac Food Sci & Technol, Ourense Campus, E-32004 Orense, Spain.
EM emamia@mums.ac.ir; jsimal@uvigo.es
RI Emami, Seyed Ahmad/IZE-9039-2023; Amiri, Mohammad Sadegh/AAA-1558-2022;
   Mohtashami, Leila/AAF-2841-2019; Simal-Gandara, Jesus/A-9533-2009
OI Mohtashami, Leila/0000-0001-5628-6253; Simal-Gandara,
   Jesus/0000-0001-9215-9737; Amiri, Mohammad Sadegh/0000-0003-2892-4523;
   Emami, Seyed Ahmad/0000-0003-4298-3132; Sobhani,
   Zahra/0000-0003-3696-4242
FU Mashhad University of Medical Sciences Research Council
FX The authors would like to acknowledge Mashhad University of Medical
   Sciences Research Council for supporting this study. Funding for open
   access charge: Universidade de Vigo/CISUG.
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NR 179
TC 16
Z9 18
U1 0
U2 29
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-1147
EI 1750-3841
J9 J FOOD SCI
JI J. Food Sci.
PD APR
PY 2022
VL 87
IS 4
BP 1386
EP 1422
DI 10.1111/1750-3841.16085
EA MAR 2022
PG 37
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA 0K8UZ
UT WOS:000767955500001
PM 35279837
OA Green Published
DA 2025-06-11
ER

PT J
AU Sun, HL
   Wu, YW
   Bian, HG
   Yang, H
   Wang, H
   Meng, XM
   Jin, J
AF Sun, Hao-lu
   Wu, Yi-wan
   Bian, He-ge
   Yang, Hui
   Wang, Heng
   Meng, Xiao-ming
   Jin, Juan
TI Function of Uric Acid Transporters and Their Inhibitors in
   Hyperuricaemia
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Article
DE uric acid; transporters; gene; hyperuricaemia; inhibitor
ID GENOME-WIDE ASSOCIATION; URATE-ANION EXCHANGER; BRUSH-BORDER MEMBRANE;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; XANTHINE-OXIDASE; MISSENSE
   VARIANT; RECURRENT GOUT; SERUM LEPTIN; DOSE ASPIRIN
AB Disorders of uric acid metabolism may be associated with pathological processes in many diseases, including diabetes mellitus, cardiovascular disease, and kidney disease. These diseases can further promote uric acid accumulation in the body, leading to a vicious cycle. Preliminary studies have proven many mechanisms such as oxidative stress, lipid metabolism disorders, and rennin angiotensin axis involving in the progression of hyperuricaemia-related diseases. However, there is still lack of effective clinical treatment for hyperuricaemia. According to previous research results, NPT1, NPT4, OAT1, OAT2, OAT3, OAT4, URAT1, GLUT9, ABCG2, PDZK1, these urate transports are closely related to serum uric acid level. Targeting at urate transporters and urate-lowering drugs can enhance our understanding of hyperuricaemia and hyperuricaemia-related diseases. This review may put forward essential references or cross references to be contributed to further elucidate traditional and novel urate-lowering drugs benefits as well as provides theoretical support for the scientific research on hyperuricemia and related diseases.
C1 [Sun, Hao-lu; Wu, Yi-wan; Bian, He-ge; Yang, Hui; Jin, Juan] Anhui Med Univ, Dept Pharmacol, Hefei, Peoples R China.
   [Wang, Heng; Meng, Xiao-ming] Anhui Med Univ, Sch Pharm, Anhui Inst Innovat Drugs, Inflammat & Immune Mediated Dis Lab Anhui Prov, Hefei, Peoples R China.
C3 Anhui Medical University; Anhui Medical University
RP Jin, J (corresponding author), Anhui Med Univ, Dept Pharmacol, Hefei, Peoples R China.; Meng, XM (corresponding author), Anhui Med Univ, Sch Pharm, Anhui Inst Innovat Drugs, Inflammat & Immune Mediated Dis Lab Anhui Prov, Hefei, Peoples R China.
EM mengxiaoming@ahmu.edu.cn; jinjuan@ahmu.edu.cn
RI Jiang, Jun/ABC-3959-2020
FU National Natural Science Foundation of China [81570623, 8197058];
   Science and Technological Fund of Anhui Province for Outstanding Youth
   of China [1608085J07]; Research Foundation Project of the Anhui
   Institute of Translational Medicine [2017zhyx01]; Promotion plan of
   basic and clinical cooperative research in Anhui Medical University
   [2019xkjT014, 2020xkjT016]
FX This work is supported by the National Natural Science Foundation of
   China (grant number 81570623 and 8197058; the Science and Technological
   Fund of Anhui Province for Outstanding Youth of China (grant number
   1608085J07); and the Research Foundation Project of the Anhui Institute
   of Translational Medicine (grant number 2017zhyx01). Promotion plan of
   basic and clinical cooperative research in Anhui Medical University
   (No.2019xkjT014; No.2020xkjT016)
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NR 179
TC 58
Z9 68
U1 9
U2 76
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD JUL 14
PY 2021
VL 12
AR 667753
DI 10.3389/fphar.2021.667753
PG 15
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA TT9UN
UT WOS:000680688700001
PM 34335246
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Simmen, FA
   Alhallak, I
   Simmen, RCM
AF Simmen, Frank A.
   Alhallak, Iad
   Simmen, Rosalia C. M.
TI Malic enzyme 1 (ME1) in the biology of cancer: it is not just
   intermediary metabolism
SO JOURNAL OF MOLECULAR ENDOCRINOLOGY
LA English
DT Review
DE malic enzyme; glutathione; thioredoxin; NADPH; hyperinsulinemia; cancer
ID EPITHELIAL-MESENCHYMAL TRANSITION; PENTOSE-PHOSPHATE PATHWAY; CELLS;
   EXPRESSION; INSULIN; COLON; SURVIVAL; PROLIFERATION; ACCUMULATION;
   GROWTH
AB Malic enzyme 1 (ME1) is a cytosolic protein that catalyzes the conversion of malate to pyruvate while concomitantly generating NADPH from NADP. Early studies identified ME1 as a mediator of intermediary metabolism primarily through its participatory roles in lipid and cholesterol biosynthesis. ME1 was one of the first identified insulin-regulated genes in liver and adipose and is a transcriptional target of thyroxine. Multiple studies have since documented that ME1 is pro-oncogenic in numerous epithelial cancers. In tumor cells, the reduction of ME1 gene expression or the inhibition of its activity resulted in decreases in proliferation, epithelial-to-mesenchymal transition and in vitro migration, and conversely, in promotion of oxidative stress, apoptosis and/or cellular senescence. Here, we integrate recent findings to highlight ME1's role in oncogenesis, provide a rationale for its nexus with metabolic syndrome and diabetes, and raise the prospects of targeting the cytosolic NADPH network to improve therapeutic approaches against multiple cancers.
C1 [Simmen, Frank A.; Alhallak, Iad; Simmen, Rosalia C. M.] Univ Arkansas Med Sci, Dept Physiol & Biophys, Little Rock, AR 72205 USA.
   [Simmen, Frank A.; Simmen, Rosalia C. M.] Univ Arkansas Med Sci, Winthrop P Rockefeller Canc Inst, Little Rock, AR 72205 USA.
C3 University of Arkansas System; University of Arkansas Medical Sciences;
   University of Arkansas System; University of Arkansas Medical Sciences
RP Simmen, FA (corresponding author), Univ Arkansas Med Sci, Dept Physiol & Biophys, Little Rock, AR 72205 USA.; Simmen, FA (corresponding author), Univ Arkansas Med Sci, Winthrop P Rockefeller Canc Inst, Little Rock, AR 72205 USA.
EM simmenfranka@uams.edu
RI Simmen, Frank/J-9464-2012
OI Alhallak, Iad/0000-0001-9200-9587
FU National Institutes of Health [R01CA136493]; National Institutes of
   Health (Translational Research Institute) [U54 TR001629]; UAMS
   intramural grant program (Medical Research Endowment); UAMS intramural
   grant program (Winthrop P. Rockefeller Cancer Institute Cancer
   Prevention and Population Science Program); UAMS intramural grant
   program (Chancellor's Research Development Award)
FX Research from our laboratories was supported by the National Institutes
   of Health (R01CA136493; Translational Research Institute grant U54
   TR001629) and UAMS intramural grant programs (Medical Research
   Endowment; Winthrop P. Rockefeller Cancer Institute Cancer Prevention
   and Population Science Program; Chancellor's Research Development
   Award). The content is solely the responsibility of the authors.
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NR 80
TC 47
Z9 52
U1 3
U2 26
PU BIOSCIENTIFICA LTD
PI BRISTOL
PA STARLING HOUSE, 1600 BRISTOL PARKWAY N, BRISTOL, ENGLAND
SN 0952-5041
EI 1479-6813
J9 J MOL ENDOCRINOL
JI J. Mol. Endocrinol.
PD NOV
PY 2020
VL 65
IS 4
BP R77
EP R90
DI 10.1530/JME-20-0176
PG 14
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA OE5DU
UT WOS:000580551600007
PM 33064660
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Guvenc, M
   Guvenc, AN
   Yilmaz, Ö
   Tuzcu, M
AF Guvenc, Mehmet
   Guvenc, Ayse Nilay
   Yilmaz, Okkes
   Tuzcu, Mehmet
TI Effect of Resveratrol on Fatty Acid Compositions and Lipophilic Vitamins
   of Fructose Induced Nonalcoholic Fatty Liver
SO PAKISTAN JOURNAL OF ZOOLOGY
LA English
DT Article
DE Resveratroll; Fructose; Fatty acids; Alfa-tocoferoll; Vitamin D3;
   Cholesterol; Retinol
ID INDUCED OXIDATIVE STRESS; ALPHA-TOCOPHEROL; METABOLIC SYNDROME; SERUM
   RETINOL; GREEN TEA; DISEASE; CHOLESTEROL; RECEPTOR; PROTECTS; OBESITY
AB in this study, the effect of resveratrol on the liver of rats induced by fructose was investigated. Adult male Winstar rats were randomly divided into four groups; control, resveratrol, fructose, and resveratrol plus fructose. Resveratrol was administered 30 mg/kg intraperitoneally. Fructose (10% w/v) was administered with drinking water for 56 days every alternate day. Fructose administration increased the hepatic omega-6/omega-3 and 16:1 n7 / 16:0 ratios (p<0.001, p<0.001), but decreased the retinol and alfa tocoferol levels (p<0.01) compared with control group. Resveratrol administration to fructose treated rats decreased the retinol and cholesterol levels (p<0.01, p<0.05), and increased alfa tocoferol and vitamin d(3) levels (p<0.01) in the liver. Our results suggest that resveratrol act as a bioregulator for some biochemical parameters in fructose induced non-alcoholic fatty liver.
C1 [Guvenc, Mehmet] Adiyaman Univ, Fac Sci, Dept Biol, TR-02100 Adiyaman, Turkey.
   [Yilmaz, Okkes; Tuzcu, Mehmet] Firat Univ, Fac Sci, Dept Biol, TR-23119 Elazig, Turkey.
   [Guvenc, Ayse Nilay] Adiyaman Univ, Vocat Sch Hlth Serv, Adiyaman, Turkey.
C3 Adiyaman University; Firat University; Adiyaman University
RP Guvenc, M (corresponding author), Adiyaman Univ, Fac Sci, Dept Biol, TR-02100 Adiyaman, Turkey.
EM mguvenc764@gmail.com
RI YILMAZ, OKKES/W-2478-2018; GUVENC, MEHMET/A-7516-2018; Tuzcu,
   Mehmet/H-2953-2018
OI GUVENC, MEHMET/0000-0001-9383-7077; Tuzcu, Mehmet/0000-0002-1329-3143
FU Department of Scientific Research Project Management of Adiyaman
   University (ADYUBAP) [2009-0017]
FX The authors thank the Department of Scientific Research Project
   Management of Adiyaman University (ADYUBAP) for the financial support of
   the project FEFBAP (2009-0017).
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NR 73
TC 1
Z9 1
U1 0
U2 4
PU ZOOLOGICAL SOC PAKISTAN
PI LAHORE
PA UNIV PUNJAB, NEW CAMPUS, C/O DEPT ZOOLOGY, LAHORE, PAKISTAN
SN 0030-9923
J9 PAK J ZOOL
JI Pak. J. Zool.
PD DEC
PY 2017
VL 49
IS 6
BP 2103
EP 2111
DI 10.17582/journal.pjz/2017.49.6.2103.2111
PG 9
WC Zoology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Zoology
GA FW0EQ
UT WOS:000424964600021
OA hybrid
DA 2025-06-11
ER

PT J
AU Corella, D
   Ordovás, JM
AF Corella, Dolores
   Ordovas, Jose M.
TI How does the Mediterranean diet promote cardiovascular health? Current
   progress toward molecular mechanisms
SO BIOESSAYS
LA English
DT Article
DE cardiovascular; epigenomics; Mediterranean diet; microRNAs;
   nutrigenetics; nutrigenomics; stroke
ID RISK-FACTORS; FATTY-ACIDS; DNA METHYLATION; GLYCEMIC LOAD; STYLE DIET;
   ENDOTHELIAL DYSFUNCTION; INFLAMMATORY MARKERS; INSULIN-RESISTANCE;
   METABOLIC SYNDROME; OXIDATIVE STRESS
AB Epidemiological evidence supports a health-promoting effect of the Mediterranean Diet (MedDiet), especially in the prevention of cardiovascular diseases. These cardiovascular benefits have been attributed to a number of components of the MedDiet such as monounsaturated fatty acids, antioxidant vitamins and phytochemicals. However, the underlying mechanisms remain unknown. Likewise, little is known about the genes that define inter-individual variation in response to the MedDiet, although the TCF7L2 gene is emerging as an illustrative candidate for determining relative risk of cardiovascular events in response to the MedDiet. Moreover, omics technologies are providing evidence supporting potential mechanisms, some of them implicating epigenetics (i.e. microRNAs, methylation), and certain data suggest that some traditional foods could contribute via microRNAs possibly acting as exogenous regulators of gene expression. Future research should aim at increasing and consolidating the nutrigenetic and nutrigenomic knowledge of the MedDiet in order to provide sound, personalized and optimized nutritional recommendations.
C1 [Corella, Dolores] Univ Valencia, Sch Med, Dept Prevent Med & Publ Hlth, Valencia, Spain.
   [Corella, Dolores] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr, Madrid, Spain.
   [Ordovas, Jose M.] CNIC, Dept Cardiovasc Epidemiol & Populat Genet, Madrid, Spain.
   [Ordovas, Jose M.] IMDEA Alimentac, Madrid, Spain.
   [Ordovas, Jose M.] Tufts Univ, Nutr & Genom Lab, JM USDA Human Nutr Res Ctr Aging, Boston, MA 02111 USA.
C3 University of Valencia; Instituto de Salud Carlos III; CIBER - Centro de
   Investigacion Biomedica en Red; CIBEROBN; Centro Nacional de
   Investigaciones Cardiovasculares (CNIC); United States Department of
   Agriculture (USDA); Tufts University
RP Corella, D (corresponding author), Univ Valencia, Sch Med, Dept Prevent Med & Publ Hlth, Valencia, Spain.
EM dolores.corella@uv.es
RI Corella, Dolores/L-9888-2014; Ordovas, Jose/B-8727-2013
OI Ordovas, Jose/0000-0002-7581-5680
FU Spanish Ministry of Health (Instituto de Salud Carlos III); Ministry of
   Economy and Innovation, Spain; Fondo Europeo de Desarrollo Regional
   [CIBER 06/03, CNIC-06, PI11/02505, AGL2010-22319-C03-03]; Generalitat
   Valenciana, Spain [ACOMP/2013/165, ACOMP/2013/159]; U.S. Department of
   Agriculture [58-1950-0-014]
FX This study has been supported by The Spanish Ministry of Health
   (Instituto de Salud Carlos III) and the Ministry of Economy and
   Innovation, Spain and Fondo Europeo de Desarrollo Regional (projects
   CIBER 06/03, CNIC-06, PI11/02505, AGL2010-22319-C03-03) and by the
   Generalitat Valenciana, Spain (ACOMP/2013/165 and ACOMP/2013/159). This
   material is based upon work supported by the U.S. Department of
   Agriculture, under agreement No. 58-1950-0-014. Any opinions, findings,
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NR 118
TC 35
Z9 36
U1 1
U2 45
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0265-9247
EI 1521-1878
J9 BIOESSAYS
JI Bioessays
PD MAY
PY 2014
VL 36
IS 5
BP 526
EP 537
DI 10.1002/bies.201300180
PG 12
WC Biochemistry & Molecular Biology; Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics
GA AE5RR
UT WOS:000334047000014
PM 24706458
OA Bronze
DA 2025-06-11
ER

PT J
AU Rajwani, A
   Cubbon, RM
   Wheatcroft, SB
AF Rajwani, A.
   Cubbon, R. M.
   Wheatcroft, S. B.
TI Cell-specific insulin resistance: implications for atherosclerosis
SO DIABETES-METABOLISM RESEARCH AND REVIEWS
LA English
DT Review
DE insulin resistance; atherosclerosis; endothelial; vascular
ID ENDOTHELIAL PROGENITOR CELLS; CORONARY-HEART-DISEASE; NITRIC-OXIDE;
   NEOINTIMA FORMATION; PPAR-GAMMA; ADVENTITIAL FIBROBLASTS; IMPAIRED
   PROLIFERATION; CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; MACROPHAGE
AB Insulin resistance is increasingly acknowledged as an independent risk factor for cardiovascular disease. Despite this, our understanding of the cellular and molecular mechanisms that might account for this relationship remain incompletely understood. A key challenge has been in distinguishing between a whole-body milieu of inflammation and oxidative stress from the ramifications of cell-specific resistance to insulin. Transgenic models have now begun to explore the cellular influences of insulin resistance on vascular biology, with novel implications for atherosclerosis across a range of cells including endothelial cells, endothelial progenitor cells, vascular smooth muscle cells, macrophages and fibroblasts. Emerging data from these models have also begun to challenge conventional dogma. In particular, the findings across various cell types are disparate with some even implying a protective influence on vascular biology. We now review these data, highlighting recent advances in our understanding of cellular resistance to insulin as well as those areas where there remains a paucity of data. Copyright (C) 2012 John Wiley & Sons, Ltd.
C1 [Wheatcroft, S. B.] Univ Leeds, Leeds Inst Genet Heath & Therapeut, Div Cardiovasc & Diabet Res, Leeds LS2 9JT, W Yorkshire, England.
   Univ Leeds, Multidisciplinary Cardiovasc Res Ctr, Leeds LS2 9JT, W Yorkshire, England.
C3 University of Leeds; University of Leeds
RP Wheatcroft, SB (corresponding author), Univ Leeds, Leeds Inst Genet Heath & Therapeut, Div Cardiovasc & Diabet Res, Clarendon Way, Leeds LS2 9JT, W Yorkshire, England.
EM s.b.wheatcroft@leeds.ac.uk
OI Rajwani, Adil/0000-0002-9228-4156; Rajwani, Adil/0000-0002-4196-7205
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NR 87
TC 18
Z9 19
U1 0
U2 15
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1520-7552
EI 1520-7560
J9 DIABETES-METAB RES
JI Diabetes-Metab. Res. Rev.
PD NOV
PY 2012
VL 28
IS 8
BP 627
EP 634
DI 10.1002/dmrr.2336
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 032QB
UT WOS:000310732900001
PM 22987644
DA 2025-06-11
ER

PT J
AU Fiorino, P
   Evangelista, FS
   Santos, F
   Magri, FMM
   Delorenzi, JCMOB
   Ginoza, M
   Farah, V
AF Fiorino, Patricia
   Evangelista, Fabiana Sant'Anna
   Santos, Fernando
   Motter Magri, Fatima Maria
   Delorenzi, Jan Carlo Morais O. B.
   Ginoza, Milton
   Farah, Vera
TI The Effects of Green Tea Consumption on Cardiometabolic Alterations
   Induced by Experimental Diabetes
SO EXPERIMENTAL DIABETES RESEARCH
LA English
DT Article
ID HEART-RATE-VARIABILITY; SPECTRAL-ANALYSIS; BLOOD-PRESSURE; OXIDATIVE
   STRESS; AUTONOMIC NEUROPATHY; METABOLIC SYNDROME; STREPTOZOTOCIN;
   HYPERTENSION; CATECHINS; POLYPHENOLS
AB We evaluated cardiac autonomic modulation by heart rate (HRV), and arterial pressure variability (APV), and metabolic response in streptozotocin diabetic rats treated with green tea. Male Wistar rats were separated in groups: control, drinking tap water (C), green tea-treated (GT) group, diabetic, drinking tap water (D), and diabetic, treated with green tea (DGT). Kidney mass was greater in D and DGT than in C and GT, but reduced in DGT compared to D. Green tea prevented the increase in creatinine clearance and reduced hyperglycemia in DGT compared to D. Arterial pressure was increased in GT and decreased in D compared to C. HRV was reduced in D compared with all groups. APV was decreased in D compared to C and recovery in DGT. Sympathetic modulation of APV was decreased in D compared with all groups. Green tea reduced hyperglycemia, prevented renal injury and autonomic dysfunction, suggesting reduced cardiovascular risk and target organ damage in diabetes.
C1 [Fiorino, Patricia; Santos, Fernando; Motter Magri, Fatima Maria; Delorenzi, Jan Carlo Morais O. B.; Ginoza, Milton; Farah, Vera] Univ Prebiteriana Mackenzie, Renal Cardiovasc & Metab Physiopharmacol Lab, Hlth & Biol Sci Ctr, BR-01302907 Sao Paulo, Brazil.
   [Evangelista, Fabiana Sant'Anna] Univ Prebiteriana Mackenzie, Sch Arts Sci & Humanities, BR-01302907 Sao Paulo, Brazil.
RP Farah, V (corresponding author), Univ Prebiteriana Mackenzie, Renal Cardiovasc & Metab Physiopharmacol Lab, Hlth & Biol Sci Ctr, BR-01302907 Sao Paulo, Brazil.
EM verafarah@mackenzie.br
RI Delorenzi, JanCarlo/L-9832-2016; dos'Santos, Fernando/LUY-1291-2024;
   Farah, Vera/ABA-1171-2021; Evangelista, Fabiana/A-5298-2013
OI Evangelista, Fabiana/0000-0002-8103-6923; dos Santos,
   Fernando/0000-0002-9147-5137; Delorenzi, Jan Carlo/0000-0003-0100-6482;
   Farah, Vera/0000-0002-5439-3079
FU PF Fundo Mackenzie de Pesquisa do Instituto Presbiteriano Mackenzie
   [059/2011]; FSE Fundacao de Amparo a Pesquisa do Estado de Sao Paulo
   [2011/02126-6]; VF Fundacao de Amparo a Pesquisa do Estado de Sao Paulo
   [2009/52556-7]; Vinnova [2011-02126] Funding Source: Vinnova
FX This paper received financial support from PF Fundo Mackenzie de
   Pesquisa do Instituto Presbiteriano Mackenzie 059/2011, FSE Fundacao de
   Amparo a Pesquisa do Estado de Sao Paulo 2011/02126-6, and VF Fundacao
   de Amparo a Pesquisa do Estado de Sao Paulo 2009/52556-7. The authors
   acknowledge Nicole Paradella Calassi and Patricia Gisele Araujo Dudas
   for technical assistance, also acknowledge Dr. Stephen L. Hurst for
   reviewing the paper and providing helpful comments.
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NR 54
TC 13
Z9 14
U1 1
U2 18
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1687-5214
EI 1687-5303
J9 EXP DIABETES RES
JI Exp. Diabetes Res.
PY 2012
AR 309231
DI 10.1155/2012/309231
PG 7
WC Endocrinology & Metabolism; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Research & Experimental Medicine
GA 906MX
UT WOS:000301350600001
PM 22474420
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Sarigianni, M
   Bekiari, E
   Tsapas, A
   Konstantinidis, D
   Kaloyianni, M
   Koliakos, G
   Paletas, K
AF Sarigianni, Maria
   Bekiari, Eleni
   Tsapas, Apostolos
   Konstantinidis, Diamantis
   Kaloyianni, Martha
   Koliakos, George
   Paletas, Konstantinos
TI Effect of Epinephrine and Insulin Resistance on Human Monocytes Obtained
   From Lean and Obese Healthy Participants: A Pilot Study
SO ANGIOLOGY
LA English
DT Article
DE atherosclerosis; obesity; insulin resistance; epinephrine; monocytes
ID SYMPATHETIC-NERVOUS-SYSTEM; TUMOR-NECROSIS-FACTOR; ADRENERGIC
   MODULATION; SCAVENGER RECEPTORS; METABOLIC SYNDROME; NA+/H+-EXCHANGER;
   BETA-BLOCKER; ACTIVATION; ADRENALINE; STRESS
AB We assessed the effect of epinephrine on human monocytes. Monocytes were isolated from 16 healthy obese and 10 lean healthy subjects. Insulin sensitivity was assessed by euglycemic hyperinsulinemic clamp. Obese subjects were subdivided into 2 sub-groups, insulin sensitive (IS) and insulin resistant (IR). Monocyte properties [attachment to laminin 1, migration through laminin 1, oxidized-low density lipoprotein (oxLDL) phagocytosis] were assessed pre- and post-stimulation in vitro with epinephrine. Experiments were repeated after incubation with a Na+/H (+) exchanger-1 inhibitor (NHE-1) (cariporide). Epinephrine increased monocyte attachment to laminin in lean and obese IR subjects through involvement of NHE-1, PKC, NO synthase, NADPH oxidase and actin polymerization. In contrast, epinephrine did not affect monocyte migration. Epinephrine increased oxLDL phagocytosis in all groups studied. Incubation with cariporide attenuated oxLDL phagocytosis. Epinephrine induces monocyte dysfunction which may be atherogenic.
C1 [Sarigianni, Maria; Bekiari, Eleni; Tsapas, Apostolos; Paletas, Konstantinos] Aristotle Univ Thessaloniki, Metab Dis Unit, Dept Internal Med 2, Sch Med, Thessaloniki, Greece.
   Harris Manchester Med Acad, Oxford, England.
   [Konstantinidis, Diamantis; Kaloyianni, Martha] Aristotle Univ Thessaloniki, Physiol Anim Lab, Dept Zool, Sch Biol, Thessaloniki, Greece.
   [Koliakos, George] Aristotle Univ Thessaloniki, Dept Biol Chem, Sch Med, Thessaloniki, Greece.
C3 Aristotle University of Thessaloniki; University of Oxford; Aristotle
   University of Thessaloniki; Aristotle University of Thessaloniki
RP Paletas, K (corresponding author), 15 Ag Sofias Str, Thessaloniki 54623, Greece.
EM paletas@med.auth.gr
RI Koliakos, George/AAC-8888-2021; Tsapas, Apostolos/B-7881-2010
OI Koliakos, George/0000-0003-4350-9061; Sarigianni,
   Maria/0000-0003-4946-0799; Tsapas, Apostolos/0000-0003-0221-4072;
   Bekiari, Eleni/0000-0001-9975-3835
FU "Reinforcement Programme of Human Research Manpower" (PENED) [03ED29];
   Greek Ministry of Development-General Secretariat of Research and
   Technology; EU
FX The author(s) disclosed receipt of the following financial support for
   the research and/or authorship of this article: This article is part of
   the 03ED29 research project, implemented within the framework of the
   "Reinforcement Programme of Human Research Manpower" (PENED) and
   co-financed by National and European Community Funds (25% from the Greek
   Ministry of Development-General Secretariat of Research and Technology
   and 75% from EU-European Social Fund).
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NR 58
TC 3
Z9 3
U1 1
U2 5
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0003-3197
EI 1940-1574
J9 ANGIOLOGY
JI Angiology
PD JAN
PY 2011
VL 62
IS 1
BP 38
EP 45
DI 10.1177/0003319710371616
PG 8
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 690KU
UT WOS:000285004500007
PM 20682615
DA 2025-06-11
ER

PT J
AU Mitsuishi, M
   Miyashita, K
   Itoh, H
AF Mitsuishi, Masanori
   Miyashita, Kazutoshi
   Itoh, Hiroshi
TI cGMP rescues mitochondrial dysfunction induced by glucose and insulin in
   myocytes
SO BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
LA English
DT Article
DE cGMP-1 mitochondria; diabetes; insulin resistance; skeletal muscle;
   mitochondrial biogenesis; reactive oxygen species; calorie restriction;
   PGC1
ID HUMAN SKELETAL-MUSCLE; OXIDATIVE STRESS; BIOGENESIS; METABOLISM
AB Mitochondrial dysfunction in the skeletal muscle has been implicated in a wide variety of pathological processes including insulin resistance in type 2 diabetes. A recent report indicates that calorie restriction can modulate mitochondrial function through the nitric oxide/cGMP-dependent pathway. Following up on these findings, we examined whether cGMP could rescue mitochondrial dysfunction in C2C12 myotubular cells induced by conditions of high-glucose and high-insulin. Treatment of the cells with cGMP promoted mitochondrial biogenesis and ATP synthesis without enhancing production of reactive oxygen species (ROS) in association with up-regulation of the genes involved in oxidative phosphorylation and ROS reduction. The increased mitochondria were revealed to have lower membrane potential, which is similar to the effect of calorie restriction, and reversed mitochondrial dysfunction caused by high-glucose and high-insulin. These results indicated that augmented cGMP-dependent cascades in the skeletal muscle may attenuate insulin resistance observed in patients with type 2 diabetes and metabolic syndrome. (c) 2008 Elsevier Inc. All rights reserved.
C1 [Mitsuishi, Masanori; Miyashita, Kazutoshi; Itoh, Hiroshi] Keio Univ, Sch Med, Dept Internal Med, Tokyo 1608582, Japan.
C3 Keio University
RP Miyashita, K (corresponding author), Keio Univ, Sch Med, Dept Internal Med, 35 Shinano Machi,Res Pk 5N8, Tokyo 1608582, Japan.
EM miyakaz@sc.itc.keio.ac.jp
OI Miyashita, Kazutoshi/0000-0003-3757-4334
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NR 20
TC 36
Z9 38
U1 0
U2 4
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0006-291X
EI 1090-2104
J9 BIOCHEM BIOPH RES CO
JI Biochem. Biophys. Res. Commun.
PD MAR 21
PY 2008
VL 367
IS 4
BP 840
EP 845
DI 10.1016/j.bbrc.2008.01.017
PG 6
WC Biochemistry & Molecular Biology; Biophysics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics
GA 263XA
UT WOS:000253248600021
PM 18194668
DA 2025-06-11
ER

PT J
AU An, JR
   Wang, QF
   Sun, GY
   Su, JN
   Liu, JT
   Zhang, C
   Wang, L
   Teng, D
   Yang, YF
   Shi, Y
AF An, Ji-Ren
   Wang, Qing-Feng
   Sun, Gui-Yan
   Su, Jia-Nan
   Liu, Jun-Tong
   Zhang, Chi
   Wang, Li
   Teng, Dan
   Yang, Yu-Feng
   Shi, Yan
TI The Role of Iron Overload in Diabetic Cognitive Impairment: A Review
SO DIABETES METABOLIC SYNDROME AND OBESITY
LA English
DT Review
DE diabetic cognitive impairment; type 1 diabetes mellitus; type 2 diabetes
   mellitus; iron overload; iron transport; iron homeostasis
ID OXIDATIVE STRESS; INSULIN-RESISTANCE; PARKINSONS-DISEASE;
   ALZHEIMERS-DISEASE; METABOLIC SYNDROME; SERUM FERRITIN; ANIMAL-MODEL;
   BRAIN; HEPCIDIN; MELLITUS
AB It is well documented that diabetes mellitus (DM) is strongly associated with cognitive decline and structural damage to the brain. Cognitive deficits appear early in DM and continue to worsen as the disease progresses, possibly due to different underlying mechanisms. Normal iron metabolism is necessary to maintain normal physiological functions of the brain, but iron deposition is one of the causes of some neurodegenerative diseases. Increasing evidence shows that iron overload not only increases the risk of DM, but also contributes to the development of cognitive impairment. The current review highlights the role of iron overload in diabetic cognitive impairment (DCI), including the specific location and regulation mechanism of iron deposition in the diabetic brain, the factors that trigger iron deposition, and the consequences of iron deposition. Finally, we also discuss possible therapies to improve DCI and brain iron deposition.
C1 [An, Ji-Ren; Wang, Qing-Feng; Sun, Gui-Yan; Su, Jia-Nan; Liu, Jun-Tong; Zhang, Chi; Wang, Li; Yang, Yu-Feng; Shi, Yan] Liaoning Univ Tradit Chinese Med, Liaoning Key Lab Chinese Med Combining Dis & Syndr, Shenyang 110847, Peoples R China.
   [An, Ji-Ren] Hebei Univ Chinese Med, Coll Integrat Chinese & Western Med, Shijiazhuang 050200, Peoples R China.
   [Teng, Dan] He Univ, Shenyang 110163, Peoples R China.
   [Yang, Yu-Feng; Shi, Yan] Liaoning Univ Tradit Chinese Med, Liaoning Key Lab Chinese Med Combining Dis & Syndr, 79 Mt Chong East Rd, Shenyang 110847, Peoples R China.
C3 Liaoning University of Traditional Chinese Medicine; Hebei University of
   Chinese Medicine; Liaoning University of Traditional Chinese Medicine
RP Yang, YF; Shi, Y (corresponding author), Liaoning Univ Tradit Chinese Med, Liaoning Key Lab Chinese Med Combining Dis & Syndr, 79 Mt Chong East Rd, Shenyang 110847, Peoples R China.
EM lntcmyyf@126.com; lntcmshiyan@163.com
RI Su, Jianan/JVE-3172-2024; An, Ji-Ren/ISB-8366-2023
OI Su, Jia-Nan/0009-0003-2487-7923; An, Ji-Ren/0000-0001-5274-8289; Sun,
   Gui-Yan/0000-0002-1964-0257
FU General project of Education Department of Liaoning Province [L202027];
   Applied Basic Research Program of Liaoning Province [2022JH2/101300108,
   2023JH2/101300050]; Project of Liaoning Provincial Department of
   Education [LJKMZ20221980]
FX Funding This research was supported by the General project of Education
   Department of Liaoning Province (No: L202027) ; Applied Basic Research
   Program of Liaoning Province (No: 2022JH2/101300108, 2023JH2/101300050)
   ; Project of Liaoning Provincial Department of Education (No:
   LJKMZ20221980) .
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NR 153
TC 2
Z9 3
U1 2
U2 9
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-7007
J9 DIABET METAB SYND OB
JI Diabetes Metab. Syndr. Obes.
PY 2023
VL 16
BP 3235
EP 3247
DI 10.2147/DMSO.S432858
PG 13
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA U8CV5
UT WOS:001087036100001
PM 37872972
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Zhang, Y
   Balasooriya, H
   Sirisena, S
   Ng, K
AF Zhang, Yi
   Balasooriya, Himali
   Sirisena, Sameera
   Ng, Ken
TI The effectiveness of dietary polyphenols in obesity management: A
   systematic review and meta-analysis of human clinical trials
SO FOOD CHEMISTRY
LA English
DT Review
DE Polyphenols; Obesity; Body weight; Body mass index; Waist circumference;
   Body fat percentage
ID FATTY LIVER-DISEASE; IMPROVES INSULIN-RESISTANCE; DOUBLE-BLIND;
   WEIGHT-LOSS; METABOLIC SYNDROME; OXIDATIVE STRESS; NATURAL-PRODUCTS;
   BODY-COMPOSITION; SOY ISOFLAVONES; ADIPOSE-TISSUE
AB Dietary polyphenols have been postulated to be effective in preventing obesity through various multitargeted mechanisms of weight loss. A meta-analysis of recent clinical trials was carried out to evaluate the effectiveness of polyphenols in obesity management in adults through assessing obesity-related anthropometric measures. Fortyfour articles with 40 randomised clinical trials published between 2010 and 2021 met the eligibility trial criteria. Pooled results showed that polyphenols had a statistically significant reduction in body weight, body mass index and waist circumference. No significant lowering effect on body fat percentage was reported. Subgroup analysis suggested that polyphenol intake significantly changed anthropometric parameters in subjects aged < 50 years, in Asian populations, in patients with obesity-related health issues, for periods of >= 3 months, and at dosages of < 220 mg d(-1). Overall, dietary polyphenols show promise in the prevention and management of obesity for certain adults.
C1 [Zhang, Yi; Balasooriya, Himali; Ng, Ken] Univ Melbourne, Fac Vet & Agr Sci, Sch Agr & Food, Parkville, Vic 3010, Australia.
   [Sirisena, Sameera] Univ Melbourne, Fac Engn & Informat Technol, Dept Chem Engn, Parkville, Vic 3010, Australia.
C3 University of Melbourne; University of Melbourne
RP Ng, K (corresponding author), Univ Melbourne, Fac Vet & Agr Sci, Sch Agr & Food, Parkville, Vic 3010, Australia.
EM ngkf@unimelb.edu.au
RI ; Sirisena, Sameera/M-9873-2015; Ng, Ken/L-5370-2015
OI Balasooriya Lekamalage, Himali Nayomika Balasooriya/0000-0003-4937-7530;
   Sirisena, Sameera/0000-0003-4924-9926; Ng, Ken/0000-0002-1843-0506
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NR 112
TC 33
Z9 35
U1 10
U2 89
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 0308-8146
EI 1873-7072
J9 FOOD CHEM
JI Food Chem.
PD MAR 15
PY 2023
VL 404
AR 134668
DI 10.1016/j.foodchem.2022.134668
EA OCT 2022
PN B
PG 16
WC Chemistry, Applied; Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Food Science & Technology; Nutrition & Dietetics
GA 6A6YQ
UT WOS:000880799000011
PM 36323021
DA 2025-06-11
ER

PT J
AU Krause, N
   Wegner, A
AF Krause, Nils
   Wegner, Andre
TI Fructose Metabolism in Cancer
SO CELLS
LA English
DT Review
DE fructose metabolism; cancer metabolism; polyol pathway; pentose
   phosphate pathway; lipogenesis; KHK; SORD; HFCS
ID FATTY-ACID SYNTHASE; ALDOSE REDUCTASE; POLYOL PATHWAY; CORN SYRUP;
   GLUCOSE TRANSPORTERS; OXIDATIVE STRESS; LIPID-METABOLISM; TRANSKETOLASE;
   EXPRESSION; TRIGLYCERIDES
AB The interest in fructose metabolism is based on the observation that an increased dietary fructose consumption leads to an increased risk of obesity and metabolic syndrome. In particular, obesity is a known risk factor to develop many types of cancer and there is clinical and experimental evidence that an increased fructose intake promotes cancer growth. The precise mechanism, however, in which fructose induces tumor growth is still not fully understood. In this article, we present an overview of the metabolic pathways that utilize fructose and how fructose metabolism can sustain cancer cell proliferation. Although the degradation of fructose shares many of the enzymes and metabolic intermediates with glucose metabolism through glycolysis, glucose and fructose are metabolized differently. We describe the different metabolic fates of fructose carbons and how they are connected to lipogenesis and nucleotide synthesis. In addition, we discuss how the endogenous production of fructose from glucose via the polyol pathway can be beneficial for cancer cells.
C1 [Krause, Nils; Wegner, Andre] Tech Univ Carolo Wilhelmina Braunschweig, Dept Bioinformat & Biochem, BRICS, D-38106 Braunschweig, Germany.
C3 Braunschweig University of Technology
RP Wegner, A (corresponding author), Tech Univ Carolo Wilhelmina Braunschweig, Dept Bioinformat & Biochem, BRICS, D-38106 Braunschweig, Germany.
EM nils.krause@tu-braunschweig.de; a.wegner@tu-bs.de
FU Ministry of Science and Culture (MWK) of Lower Saxony; Federal Ministry
   of Education and Research [PeriNAA-01ZX1916B]; German Research
   Foundation; Open Access Publication Funds of Technische Universitat
   Braunschweig
FX The authors acknowledge funding by the Ministry of Science and Culture
   (MWK) of Lower Saxony: (1) SMART BIOTECS alliance between the Technische
   Universitat Braunschweig and the Leibnitz Universitat Hannover and (2)
   Research cooperation Lower Saxony-Israel; the Federal Ministry of
   Education and Research: PeriNAA-01ZX1916B, and the German Research
   Foundation and the Open Access Publication Funds of Technische
   Universitat Braunschweig.
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NR 102
TC 56
Z9 60
U1 10
U2 63
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2073-4409
J9 CELLS-BASEL
JI Cells
PD DEC
PY 2020
VL 9
IS 12
AR 2635
DI 10.3390/cells9122635
PG 17
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA PJ4VR
UT WOS:000601767900001
PM 33302403
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Charles, LE
   Gu, JK
   Ma, CC
   Grady, LM
   Mnatsakanova, A
   Andrew, ME
   Fekedulegn, D
   Violanti, JM
   Klein, R
AF Charles, Luenda E.
   Gu, Ja K.
   Ma, Claudia C.
   Grady, Lisa M.
   Mnatsakanova, Anna
   Andrew, Michael E.
   Fekedulegn, Desta
   Violanti, John M.
   Klein, Ronald
TI Shiftwork and the Retinal Vasculature Diameters Among Police Officers
SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
LA English
DT Article
ID INTIMA-MEDIA THICKNESS; METABOLIC SYNDROME; MICROVASCULAR ABNORMALITIES;
   CARDIOVASCULAR-DISEASE; ENDOTHELIAL FUNCTION; ATHEROSCLEROSIS RISK;
   JAPANESE POPULATION; VESSEL DIAMETERS; OXIDATIVE STRESS; HEART-DISEASE
AB Objective: To investigate associations of central retinal arteriolar equivalent (CRAE), a measure of retinal arteriolar width, and central retinal venular equivalents (CRVE), a measure of retinal venular width, with shiftwork in 199 police officers (72.9% men). Methods: Shiftwork (day, afternoon, night) was assessed using electronic payroll records. Four digital retinal images per officer were taken. Mean diameters of the retinal vasculature were compared across shifts using analysis of variance (ANOVA)/analysis of covariance (ANCOVA). Results: Among all officers (mean age = 46.6 +/- 6.8 years), shiftwork was not significantly associated with CRAE or CRVE. However, among current and former smokers, night-shift officers had a wider mean (+/- standard error [SE]) CRVE (230.0 +/- 4.5 mu m) compared with day shift officers (215.1 +/- 3.5 mu m); adjusted P = 0.014. Conclusions: Night shift schedule in current and former smokers is associated with wider retinal venules. Reasons for this association are not known. Longitudinal studies are warranted.
C1 [Charles, Luenda E.; Gu, Ja K.; Ma, Claudia C.; Mnatsakanova, Anna; Andrew, Michael E.; Fekedulegn, Desta] Ctr Dis Control & Prevent, Biostat & Epidemiol Branch, Hlth Effects Lab Div, NIOSH, MS L-4050,1095 Willowdale Rd, Morgantown, WV 26505 USA.
   [Grady, Lisa M.; Klein, Ronald] Univ Wisconsin, Dept Ophthalmol & Visual Sci, Madison, WI USA.
   [Violanti, John M.] SUNY Buffalo, Dept Epidemiol & Environm Hlth, Sch Publ Hlth & Hlth Profess, Buffalo, NY USA.
C3 Centers for Disease Control & Prevention - USA; National Institute for
   Occupational Safety & Health (NIOSH); University of Wisconsin System;
   University of Wisconsin Madison; State University of New York (SUNY)
   System; University at Buffalo, SUNY
RP Charles, LE (corresponding author), Ctr Dis Control & Prevent, Biostat & Epidemiol Branch, Hlth Effects Lab Div, NIOSH, MS L-4050,1095 Willowdale Rd, Morgantown, WV 26505 USA.
EM lcharles@cdc.gov
RI Charles, Luenda/H-6008-2011
OI /0000-0002-0245-5899; Grady, Lisa/0000-0002-7529-4926; Ma, Claudia
   C./0000-0001-5639-5978
FU National Institute for Occupational Safety and Health (NIOSH)
   [200-2003-01580, 1R01OH 009640-01A1]
FX This work was supported by the National Institute for Occupational
   Safety and Health (NIOSH), contract no. 200-2003-01580 and grant no.
   (1R01OH 009640-01A1).
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NR 45
TC 3
Z9 3
U1 0
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1076-2752
EI 1536-5948
J9 J OCCUP ENVIRON MED
JI J. Occup. Environ. Med.
PD OCT
PY 2017
VL 59
IS 10
BP E172
EP E179
DI 10.1097/JOM.0000000000001136
PG 8
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA FJ2FM
UT WOS:000412539800003
PM 28820862
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Hannon, DB
   Thompson, JT
   Khoo, C
   Juturu, V
   Vanden Heuvel, JP
AF Hannon, Daniel B.
   Thompson, Jerry T.
   Khoo, Christina
   Juturu, Vijaya
   Vanden Heuvel, John P.
TI Effects of cranberry extracts on gene expression in THP-1 cells
SO FOOD SCIENCE & NUTRITION
LA English
DT Article
DE Gene expression; macrophage; nutrigenomics; proanthocyanidins; reactive
   oxygen species
ID OXIDATIVE STRESS; VACCINIUM-MACROCARPON; METABOLIC SYNDROME; JUICE
   CONSUMPTION; BLOOD-PRESSURE; COMMON FOODS; CANCER CELLS; HUMAN HEALTH;
   ANTIOXIDANT; PATHWAYS
AB Cranberry contains high levels of nutrients and bioactive molecules that have health-promoting properties. The purpose of the present studies was to determine if cranberry extracts (CEs) contain phytochemicals that exert anti-inflammatory effects. The human monocytic cell line THP-1 was treated with two CEs (CE and 90MX) and subsequently challenged with Lipopolysaccharides (LPS). Tumor necrosis factor alpha (TNF alpha) expression was decreased in the -CE-treated cells, indicative of an anti-inflammatory effect. Gene expression microarrays identified several immune-related genes that were responsive to CEs including interferon-induced protein with tetratricopeptide repeats 1 and 3 (IFIT 1 and 3), macrophage scavenger receptor 1 (MSR1) and colony-stimulating factor 2 (CSF2). In addition, in the CE-treated cells, metallothionein 1F and other metal-responsive genes were induced. Taken together, this data indicates that CEs contain bioactive components that have anti-inflammatory effects and may protect cells from oxidative damage.
C1 [Hannon, Daniel B.; Thompson, Jerry T.; Vanden Heuvel, John P.] Penn State Univ, Dept Vet & Biomed Sci, 325 Life Sci Bldg, University Pk, PA 16802 USA.
   [Hannon, Daniel B.; Thompson, Jerry T.; Vanden Heuvel, John P.] Penn State Univ, Ctr Mol Toxicol & Carcinogenesis, 325 Life Sci Bldg, University Pk, PA 16802 USA.
   [Khoo, Christina] Ocean Spray Cranberries Inc, One Ocean Spray Dr, Lakeville Middleboro, MA 02349 USA.
   [Juturu, Vijaya] UnitedBiomed Inc, 102 Hunters Run, Dobbs Ferry, NY 10502 USA.
   [Vanden Heuvel, John P.] INDIGO Biosci Inc, 1981 Pine Hall Rd, State Coll, PA 16801 USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE);
   Pennsylvania State University; Penn State Behrend; Pennsylvania State
   University - University Park; Pennsylvania Commonwealth System of Higher
   Education (PCSHE); Pennsylvania State University; Pennsylvania State
   University - University Park; Penn State Behrend
RP Vanden Heuvel, JP (corresponding author), Penn State Univ, 325 Life Sci Bldg, University Pk, PA 16802 USA.
EM jpv2@psu.edu
RI Vanden Heuvel, Jack/HPF-4030-2023
OI Juturu, Vijaya/0000-0002-8598-9027
FU Indigo Biosciences Inc.
FX JVH is an employee of Penn State University and has a financial stake
   with Indigo Biosciences Inc., which may constitute a conflict of
   interest.
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NR 47
TC 13
Z9 15
U1 0
U2 10
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2048-7177
J9 FOOD SCI NUTR
JI Food Sci. Nutr.
PD JAN
PY 2017
VL 5
IS 1
BP 148
EP 159
DI 10.1002/fsn3.374
PG 12
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA EO0EL
UT WOS:000396371000016
PM 28070326
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Huang, SC
   Lin, JJ
   Lee, MF
   Liu, YC
   Pan, BS
AF Huang, Sheng Chia
   Lin, Jing Jen
   Lee, Mong Fong
   Liu, Yeuk Chuen
   Pan, Bonnie Sun
TI Freshwater clam extracts alleviate dyslipidaemia of tilapia fed a
   high-fat diet as an animal model
SO JOURNAL OF FUNCTIONAL FOODS
LA English
DT Article
DE Tilapia; Freshwater clam; High-fat diet; Fatty streak; Dyslipidaemia;
   Hypocholesterolaemia
ID HIGH-CHOLESTEROL DIET; CORBICULA-FLUMINEA; HYPERCHOLESTEROLEMIC RATS;
   LIPOPROTEIN OXIDATION; ATLANTIC SALMON; LDL-OXIDATION; LIPID LEVEL;
   ATHEROSCLEROSIS; PROTEIN; HYDROLYSATE
AB Tilapia were used as an alternative animal model for evaluating metabolic syndrome, e.g., hyperlipidaemia and hypercholesterolaemia. Vascular lipid accumulation and inflammation of tilapia were induced by a high-fat diet (HFD) given for two weeks. The HFD triggered lipid peroxidation, high concentrations of total cholesterol and low-density lipoprotein (LDL) cholesterol in plasma, leading to hyperlipidaemia, fatty liver, and lipid accumulation in aorta intima. Tilapia fed an HFD supplemented with freshwater clam extracts (FCEs) showed improved plasma lipid profiles, reduction of liver size and decreased lipid accumulation in the liver. FCEs also enhanced plasma antioxidant status and alleviated vascular lesions in the tilapia fed an HFD. In vivo experimental results proved the atherosclerosis-preventive properties of FCEs against oxidative stress on lipid metabolism. Consequently, FCEs may serve as a potential nutraceutical ingredient to reduce the risk factors of cardiovascular diseases. (C) 2016 Elsevier Ltd. All rights reserved.
C1 [Huang, Sheng Chia; Lin, Jing Jen; Liu, Yeuk Chuen; Pan, Bonnie Sun] Natl Taiwan Ocean Univ, Dept Food Sci, Keelung 202, Taiwan.
   [Lee, Mong Fong] Natl Penghu Univ Sci & Technol, Dept Aquaculture, Magong 880, Penghu, Taiwan.
C3 National Taiwan Ocean University; National Penghu University of Science
   & Technology
RP Pan, BS (corresponding author), Natl Taiwan Ocean Univ, Dept Food Sci, Keelung 202, Taiwan.
EM bonnie@ntou.edu.tw
FU Ministry of Science and Technology of Taiwan
   [NSC-102-2324-B-019-005-CC2]
FX This study was funded by the Ministry of Science and Technology of
   Taiwan under Project Number NSC-102-2324-B-019-005-CC2.
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NR 31
TC 15
Z9 17
U1 1
U2 39
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1756-4646
J9 J FUNCT FOODS
JI J. Funct. Food.
PD AUG
PY 2016
VL 25
BP 559
EP 567
DI 10.1016/j.jff.2016.06.017
PG 9
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA DT1IF
UT WOS:000381234200049
DA 2025-06-11
ER

PT J
AU Sandor, R
   Leucuta, D
   Dronca, E
   Niculae, A
   Cret, V
   Silaghi, C
   Suciu, S
AF Sandor, Raluca
   Leucuta, Daniel
   Dronca, Eleonora
   Niculae, Alexandru
   Cret, Victoria
   Silaghi, Ciprian
   Suciu, Soimita
TI Low Serum Paraoxonase-1 Lactonase and Arylesterase Activities in Obese
   Children and Adolescents
SO REVISTA ROMANA DE MEDICINA DE LABORATOR
LA English
DT Article
DE paraoxonase; lactonase; arylesterase; childhood obesity; low density
   lipoproteins; malondialdehyde
ID HIGH-DENSITY-LIPOPROTEINS; FATTY LIVER-DISEASE; INSULIN-RESISTANCE;
   OXIDATIVE STRESS; METABOLIC SYNDROME; CHILDHOOD OBESITY;
   ENZYME-ACTIVITY; ASSOCIATION; STABILITY; LEPTIN
AB Serum paraoxonase-1 (PON1) binds mainly to high density lipoproteins (HDLs) and protects low density lipoproteins (LDLs) against oxidation. While paraoxonase and arylesterase activities are traditionally assayed, lactonase activity, accounting for protection against LDL oxidation, was less investigated in obese children and adolescents. Therefore, we aimed to measure lactonase, paraoxonase and arylesterase activities, oxidized LDL (ox-LDL) and malondialdehyde (MDA) levels in obese children and adolescents.
   Study population included 68 children (35 obese and 33 normal-weight). Arylesterase and paraoxonase activities were assayed spectrophotometrically. Lactonase activity, ox-LDL and MDA levels were measured using a pH-sensitive colorimetric assay, an ELISA technique and a fluorimetric method, respectively. The lipid profile was assessed by common methods.
   Lactonase and arylesterase activities were decreased in the presence of obesity. MDA, but not ox-LDL levels, showed significant differences between groups. Multiple regression analysis identified a reciprocal relationship and a possible association between lactonase and arylesterase activities and obesity.
C1 [Sandor, Raluca; Niculae, Alexandru] Iuliu Hatieganu Univ Med & Pharm, Fac Med, Cluj Napoca, Romania.
   [Leucuta, Daniel] Iuliu Hatieganu Univ Med & Pharm, Dept Med Informat & Biostat, Cluj Napoca, Romania.
   [Dronca, Eleonora] Iuliu Hatieganu Univ Med & Pharm, Dept Med Genet, Cluj Napoca, Romania.
   [Cret, Victoria] Paediat Emergency Cty Hosp, Paediat Clin 1, Cluj Napoca, Romania.
   [Silaghi, Ciprian] Iuliu Hatieganu Univ Med & Pharm, Dept Med Biochem, Cluj Napoca, Romania.
   [Suciu, Soimita] Iuliu Hatieganu Univ Med & Pharm, Dept Physiol, Cluj Napoca, Romania.
C3 Iuliu Hatieganu University of Medicine & Pharmacy; Iuliu Hatieganu
   University of Medicine & Pharmacy; Iuliu Hatieganu University of
   Medicine & Pharmacy; Iuliu Hatieganu University of Medicine & Pharmacy;
   Iuliu Hatieganu University of Medicine & Pharmacy
RP Dronca, E (corresponding author), Iuliu Hatieganu Univ Med & Pharm, Cluj Napoca, Romania.
EM eleonora.dronca@umfcluj.ro
RI Niculae, Alexandru/GXV-1439-2022; Dronca, Eleonora/C-3192-2011; Suciu,
   Şoimiţa/S-8470-2017; Leucuta, Daniel/E-3625-2014; Silaghi, Ciprian
   Nicolae/F-7787-2011
OI Niculae, Alexandru-Stefan/0000-0002-2771-2302; Leucuta,
   Daniel/0000-0003-4218-8622; Silaghi, Ciprian Nicolae/0000-0003-0212-726X
FU Iuliu Hatieganu University of Medicine and Pharmacy
   [22714/8/06.10.2011]; POSDRU grant [159/1.5/S/138776]
FX This study was funded by Iuliu Hatieganu University of Medicine and
   Pharmacy, grant no. 22714/8/06.10.2011. Dr. Dronca E is a fellow of
   POSDRU grant no. 159/1.5/S/138776 with title: "Model colaborativ
   institutional pentru translatarea cercetarii stiintifice biomedicale in
   practica clinica - TRANSCENT".
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NR 40
TC 5
Z9 5
U1 0
U2 22
PU SCIENDO
PI WARSAW
PA BOGUMILA ZUGA 32A, WARSAW, MAZOVIA, POLAND
SN 1841-6624
EI 2284-5623
J9 REV ROMANA MED LAB
JI Rev. Romana Med. Lab.
PD DEC
PY 2015
VL 23
IS 4
BP 385
EP 395
DI 10.1515/rrlm-2015-0038
PG 11
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA DA0EU
UT WOS:000367470600002
OA gold
DA 2025-06-11
ER

PT J
AU Silhavy, J
   Zídek, V
   Landa, V
   Simáková, M
   Mlejnek, P
   Oliyarnyk, O
   Malínská, H
   Kazdová, L
   Mancini, M
   Pravenec, M
AF Silhavy, J.
   Zidek, V.
   Landa, V.
   Simakova, M.
   Mlejnek, P.
   Oliyarnyk, O.
   Malinska, H.
   Kazdova, L.
   Mancini, M.
   Pravenec, M.
TI Rosuvastatin Ameliorates Inflammation, Renal Fat Accumulation, and
   Kidney Injury in Transgenic Spontaneously Hypertensive Rats Expressing
   Human C-Reactive Protein
SO PHYSIOLOGICAL RESEARCH
LA English
DT Article
DE Rosuvastatin; Kidney damage; CRP; Transgenic; Spontaneously hypertensive
   rat
ID DIABETIC-NEPHROPATHY; DISEASE; OUTCOMES; THERAPY; STATINS
AB Recently, we derived "humanized" spontaneously hypertensive rats (SHR-CRP) in which transgenic expression of human CRP induces inflammation, oxidative stress, several features of metabolic syndrome and target organ injury. In addition, we found that rosuvastatin treatment of SHR-CRP transgenic rats can protect against pro-inflammatory effects of human CRP and also reduce cardiac inflammation and oxidative damage. In the current study, we tested the effects of rosuvastatin (5 mg/kg) on kidney injury in SHR-CRP males versus untreated SHR-CRP and SHR controls. All rats were fed a high sucrose diet. In SHR-CRP transgenic rats, treatment with rosuvastatin for 10 weeks, compared to untreated transgenic rats and SHR controls, was associated with significantly reduced systemic inflammation which was accompanied with activation of antioxidative enzymes in the kidney, lower renal fat accumulation, and with amelioration of histopathological changes in the kidney. These findings provide evidence that, in the presence of high CRP levels, rosuvastatin exhibits significant anti-inflammatory, anti-oxidative, and renoprotective effects.
C1 [Silhavy, J.; Zidek, V.; Landa, V.; Simakova, M.; Mlejnek, P.; Pravenec, M.] Czech Acad Sci, Inst Physiol, Videnska 1083, Prague 14220 4, Czech Republic.
   [Oliyarnyk, O.; Malinska, H.; Kazdova, L.] Inst Clin & Expt Med, Ctr Med Expt, Prague, Czech Republic.
   [Mancini, M.] Univ Roma La Sapienza, Dept Radiol Oncol & Pathol, I-00185 Rome, Italy.
C3 Czech Academy of Sciences; Institute of Physiology of the Czech Academy
   of Sciences; Institute for Clinical & Experimental Medicine (IKEM);
   Sapienza University Rome
RP Pravenec, M (corresponding author), Czech Acad Sci, Inst Physiol, Videnska 1083, Prague 14220 4, Czech Republic.
EM pravenec@biomed.cas.cz
RI MANCINI, MASSIMILIANO/AAC-1583-2022; Simakova, Miroslava/R-5367-2019;
   Silhavy, Jan/B-5292-2014; Oliyarnyk, Olena/Q-6380-2019; Zidek,
   Vaclav/C-6685-2012; Pravenec, Michal/B-1666-2012; Mlejnek,
   Petr/C-2305-2012
OI Pravenec, Michal/0000-0001-9197-5871; Mlejnek, Petr/0000-0002-4218-8983;
   Oliyarnyk, Olena/0000-0002-4912-6187; Simakova,
   Miroslava/0000-0003-1468-5832; MANCINI, MASSIMILIANO/0000-0001-7465-2229
FU Ministry of Education, Youth and Sports of the Czech Republic [LH11049,
   LL1204]; Ministry of Health of the Czech Republic [NT/14325]; MH CZ-DRO
   ("Institute for Clinical and Experimental Medicine - IKEM") [IN
   0002301]; Czech Science Foundation [14-36804G]
FX This work was supported by grant LH11049 to VZ and LL1204 (within the
   ERC CZ program) to MP from the Ministry of Education, Youth and Sports
   of the Czech Republic, grant NT/14325 to MP from the Ministry of Health
   of the Czech Republic, grant MH CZ-DRO ("Institute for Clinical and
   Experimental Medicine - IKEM, IN 0002301") to LK, grant 14-36804G from
   the Czech Science Foundation to MP.
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NR 25
TC 5
Z9 5
U1 0
U2 4
PU ACAD SCIENCES CZECH REPUBLIC, INST PHYSIOLOGY
PI PRAGUE 4
PA VIDENSKA 1083, PRAGUE 4 142 20, CZECH REPUBLIC
SN 0862-8408
EI 1802-9973
J9 PHYSIOL RES
JI Physiol. Res.
PY 2015
VL 64
IS 3
BP 295
EP 301
DI 10.33549/physiolres.932797
PG 7
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA CM1AE
UT WOS:000357411100002
PM 25536316
OA gold
DA 2025-06-11
ER

PT J
AU Fleming, I
AF Fleming, Ingrid
TI The Pharmacology of the Cytochrome P450 Epoxygenase/Soluble Epoxide
   Hydrolase Axis in the Vasculature and Cardiovascular Disease
SO PHARMACOLOGICAL REVIEWS
LA English
DT Review
ID POLYUNSATURATED FATTY-ACIDS; HYPOXIC PULMONARY VASOCONSTRICTION; GAP
   JUNCTIONAL COMMUNICATION; ACTIVATED RECEPTOR-ALPHA;
   ENDOTHELIUM-DEPENDENT HYPERPOLARIZATION; POSTOPERATIVE
   ATRIAL-FIBRILLATION; INDUCED MITOCHONDRIAL DYSFUNCTION; CARDIAC-SPECIFIC
   OVEREXPRESSION; ENDOPLASMIC-RETICULUM STRESS; ISCHEMIA-REPERFUSION
   INJURY
AB Over the last 20 years, it has become clear that cytochrome P450 (P450) enzymes generate a spectrum of bioactive lipid mediators from endogenous substrates. However, studies focused on the determining biologic activity of the P450 system have focused largely on the metabolites generated by one substrate (i.e., arachidonic acid). However, epoxides and diols derived from other endogenous substrates, such as linoleic acid, eicosapentaenoic acid, and docosahexaenoic acid, may be generated in higher concentrations and may potentially be of more physiologic relevance. Recent studies that used a combination of phenotyping and lipid array analyses revealed that rather than being inactive products, fatty acid diols play important roles in a number of biologic processes including inflammation, angiogenesis, and metabolic regulation. Moreover, inhibitors of the soluble epoxide hydrolase that increase epoxide but decrease diol levels have potential for the treatment of the metabolic syndrome.
C1 Goethe Univ, Ctr Mol Med, Inst Vasc Signalling, D-60596 Frankfurt, Germany.
C3 Goethe University Frankfurt
RP Fleming, I (corresponding author), Goethe Univ, Ctr Mol Med, Inst Vasc Signalling, Theodor Stern Kai 7, D-60596 Frankfurt, Germany.
EM fleming@em.uni-frankfurt.de
RI Fleming, Ingrid/L-1225-2014
OI Fleming, Ingrid/0000-0003-1881-3635
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NR 433
TC 113
Z9 116
U1 1
U2 22
PU AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3995 USA
SN 0031-6997
EI 1521-0081
J9 PHARMACOL REV
JI Pharmacol. Rev.
PD OCT
PY 2014
VL 66
IS 4
BP 1106
EP 1140
DI 10.1124/pr.113.007781
PG 35
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA AT2HI
UT WOS:000344754100004
PM 25244930
DA 2025-06-11
ER

PT J
AU Saadat, YR
   Abbasi, A
   Hejazian, SS
   Hekmatshoar, Y
   Ardalan, M
   Farnood, F
   Vahed, SZ
AF Saadat, Yalda Rahbar
   Abbasi, Amin
   Hejazian, Seyyed Sina
   Hekmatshoar, Yalda
   Ardalan, Mohammadreza
   Farnood, Farahnoosh
   Vahed, Sepideh Zununi
TI Combating chronic kidney disease-associated cachexia: A literature
   review of recent therapeutic approaches
SO BMC NEPHROLOGY
LA English
DT Review
DE Cachexia; Chronic kidney disease; End-stage renal disease; Nutrition;
   Wasting
ID SKELETAL-MUSCLE ATROPHY; STAGE RENAL-DISEASE; CELLULAR SENESCENCE;
   MOLECULAR-MECHANISMS; INSULIN-RESISTANCE; ENERGY HOMEOSTASIS; AEROBIC
   EXERCISE; OXIDATIVE STRESS; BODY-COMPOSITION; IN-VIVO
AB In 2008, the Society on Sarcopenia, Cachexia, and Wasting Disorders introduced a generic definition for all types of cachexia: "a complex metabolic syndrome associated with the underlying illness characterized by a loss of muscle, with or without fat loss". It is well-known that the presence of inflammatory burden in end-stage renal disease (ESRD) patients may lead to the evolution of cachexia. Since the etiology of cachexia in chronic kidney disease (CKD) is multifactorial, thus the successful treatment must involve several concomitant measures (nutritional interventions, appetite stimulants, and anti-inflammatory pharmacologic agents) to provide integrated effective therapeutic modalities to combat causative factors and alleviate the outcomes of patients. Given the high mortality rate associated with cachexia, developing new therapeutic modalities are prerequisite for ameliorating patients with CKD worldwide. The present review aims to discuss some therapeutic strategies and provide an update on advances in nutritional approaches to counteract cachexia.
C1 [Saadat, Yalda Rahbar; Ardalan, Mohammadreza; Farnood, Farahnoosh; Vahed, Sepideh Zununi] Tabriz Univ Med Sci, Kidney Res Ctr, Tabriz, Iran.
   [Abbasi, Amin] Shahid Beheshti Univ Med Sci, Student Res Comm, Natl Nutr & Food Technol Res Inst, Fac Nutr Sci & Food Technol,Dept Food Sci & Techno, Tehran, Iran.
   [Hejazian, Seyyed Sina] Tabriz Univ Med Sci, Immunol Res Ctr, Tabriz, Iran.
   [Hejazian, Seyyed Sina] Tabriz Univ Med Sci, Neurosci Res Ctr, Tabriz, Iran.
   [Hekmatshoar, Yalda] Altinbas Univ, Sch Med, Dept Med Biol, Istanbul, Turkiye.
C3 Tabriz University of Medical Science; Shahid Beheshti University Medical
   Sciences; Tabriz University of Medical Science; Tabriz University of
   Medical Science; Altinbas University
RP Farnood, F; Vahed, SZ (corresponding author), Tabriz Univ Med Sci, Kidney Res Ctr, Tabriz, Iran.
EM farnoodkidney@gmail.com; sepide.zununi@gmail.com
RI Hekmatshoar, Yalda/GOK-2107-2022; Farnood, Farahnoosh/GNH-2593-2022;
   Abbasi, Amin/ACB-8198-2022; Vahed, Sepideh/W-2737-2017; Rahbar Saadat,
   Yalda/O-8109-2017
OI Hejazian, Seyyed Sina/0000-0002-8448-1539; Rahbar Saadat,
   Yalda/0000-0002-3295-404X
FU Kidney Research Center, Tabriz University of Medical Sciences, Tabriz,
   Iran
FX All authors gratefully acknowledge Kidney Research Center, Tabriz
   University of Medical Sciences, Tabriz, Iran. The authors acknowledge
   English editing by Dr. Fatemeh Zununi Vahed.
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NR 208
TC 1
Z9 1
U1 1
U2 1
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2369
J9 BMC NEPHROL
JI BMC Nephrol.
PD MAR 11
PY 2025
VL 26
IS 1
AR 133
DI 10.1186/s12882-025-04057-8
PG 23
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA Z9B2R
UT WOS:001441766300002
PM 40069669
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Zhang, SH
   Tang, SS
   Liu, YL
   Xue, BH
   Xie, QY
   Zhao, LY
   Yuan, HJ
AF Zhang, Shihan
   Tang, Shasha
   Liu, Yalei
   Xue, Binghua
   Xie, Qinyuan
   Zhao, Lingyun
   Yuan, Huijuan
TI Protein-bound uremic toxins as therapeutic targets for cardiovascular,
   kidney, and metabolic disorders
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Review
DE protein-bound uremic toxins; gut microbiota;
   cardiovascular-kidney-metabolic syndrome; metabolic diseases; management
ID TRIMETHYLAMINE-N-OXIDE; P-CRESYL SULFATE; INDOXYL SULFATE; GUT
   MICROBIOTA; INTESTINAL MICROBIOTA; HEART-FAILURE; RENAL-FAILURE; EATING
   FREQUENCY; OXIDATIVE STRESS; BLOOD-PRESSURE
AB Cardiovascular-kidney-metabolic (CKM) syndrome is a systemic clinical condition characterized by pathological and physiological interactions among metabolic abnormalities, chronic kidney disease, and cardiovascular diseases, leading to multi-organ dysfunction and a higher incidence of cardiovascular endpoints. Traditional approaches to managing CKM syndrome risk are inadequate in these patients, necessitating strategies targeting specific CKM syndrome risk factors. Increasing evidence suggests that addressing uremic toxins and/or pathways induced by uremic toxins may reduce CKM syndrome risk and treat the disease. This review explores the interactions among heart, kidney, and metabolic pathways in the context of uremic toxins and underscores the significant role of uremic toxins as potential therapeutic targets in the pathophysiology of these diseases. Strategies aimed at regulating these uremic toxins offer potential avenues for reversing and managing CKM syndrome, providing new insights for its clinical diagnosis and treatment.
C1 [Zhang, Shihan; Tang, Shasha; Liu, Yalei; Xue, Binghua; Xie, Qinyuan; Zhao, Lingyun; Yuan, Huijuan] Zhengzhou Univ, Henan Prov Peoples Hosp, Dept Endocrinol, Henan Prov Key Med Lab Intestinal Microecol & Diab, Zhengzhou, Peoples R China.
C3 Zhengzhou University
RP Yuan, HJ (corresponding author), Zhengzhou Univ, Henan Prov Peoples Hosp, Dept Endocrinol, Henan Prov Key Med Lab Intestinal Microecol & Diab, Zhengzhou, Peoples R China.
EM hjyuan@zzu.edu.cn
RI 凌云, 赵/GVS-6482-2022; Yuan, Huijuan/ABD-1037-2021; Liu,
   Yalei/GSD-8630-2022
FU National Natural Science Foundation of China [82270865]; Henan
   provincial key research and development projects [231111313200]; Henan
   provincial medical science and technology research program-the
   provincial and ministerial major projects [SBGJ202301002]
FX The author(s) declare that financial support was received for the
   research, authorship, and/or publication of this article. This study was
   supported by National Natural Science Foundation of China, No. 82270865;
   Henan provincial key research and development projects, No.
   231111313200; Henan provincial medical science and technology research
   program-the provincial and ministerial major projects, No.
   SBGJ202301002.
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NR 153
TC 0
Z9 0
U1 0
U2 0
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD JAN 27
PY 2025
VL 16
AR 1500336
DI 10.3389/fendo.2025.1500336
PG 13
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA W1J5K
UT WOS:001416224300001
PM 39931238
OA gold
DA 2025-06-11
ER

PT J
AU Tain, YL
   Hsu, CN
AF Tain, You-Lin
   Hsu, Chien-Ning
TI Maternal Polyphenols and Offspring Cardiovascular-Kidney-Metabolic
   Health
SO NUTRIENTS
LA English
DT Review
DE polyphenols; cardiovascular disease; gut microbiota; resveratrol;
   developmental origins of health and disease (DOHaD); hypertension;
   kidney disease; metabolic syndrome
ID HIGH-FAT-DIET; ARYL-HYDROCARBON RECEPTOR; OXIDATIVE STRESS; RESVERATROL
   SUPPLEMENTATION; GUT MICROBIOTA; FOOD SOURCES; DISEASE; HYPERTENSION;
   PREGNANCY; PREVENTS
AB Background: The convergence of cardiovascular, kidney, and metabolic disorders at the pathophysiological level has led to the recognition of cardiovascular-kidney-metabolic (CKM) syndrome, which represents a significant global health challenge. Polyphenols, a group of phytochemicals, have demonstrated potential health-promoting effects. Methods: This review highlights the impact of maternal polyphenol supplementation on the CKM health of offspring. Results: Initially, we summarize the interconnections between polyphenols and each aspect of CKM syndrome. We then discuss in vivo studies that have investigated the use of polyphenols during pregnancy and breastfeeding, focusing on their role in preventing CKM syndrome in offspring. Additionally, we explore the common mechanisms underlying the protective effects of maternal polyphenol supplementation. Conclusions: Overall, this review underscores the potential of early-life polyphenol interventions in safeguarding against CKM syndrome in offspring. It emphasizes the importance of continued research to advance our understanding and facilitate the clinical translation of these interventions.
C1 [Tain, You-Lin] Kaohsiung Chang Gung Mem Hosp, Div Pediat Nephrol, Kaohsiung 833, Taiwan.
   [Tain, You-Lin] Kaohsiung Chang Gung Mem Hosp, Inst Translat Res Biomed, Kaohsiung 833, Taiwan.
   [Tain, You-Lin] Chang Gung Univ, Coll Med, Taoyuan 333, Taiwan.
   [Hsu, Chien-Ning] Kaohsiung Chang Gung Mem Hosp, Dept Pharm, Kaohsiung 833, Taiwan.
   [Hsu, Chien-Ning] Kaohsiung Med Univ, Sch Pharm, Kaohsiung 807, Taiwan.
C3 Chang Gung Memorial Hospital; Chang Gung Memorial Hospital; Chang Gung
   University; Chang Gung Memorial Hospital; Kaohsiung Medical University
RP Hsu, CN (corresponding author), Kaohsiung Chang Gung Mem Hosp, Dept Pharm, Kaohsiung 833, Taiwan.; Hsu, CN (corresponding author), Kaohsiung Med Univ, Sch Pharm, Kaohsiung 807, Taiwan.
EM tainyl@cgmh.org.tw; cnhsu@cgmh.org.tw
RI Tain, You-Lin/H-2827-2019; Hsu, Chien-Ning/GLS-4014-2022
OI Hsu, Chien-Ning/0000-0001-7470-528X; Tain, You-Lin/0000-0002-7059-6407
FU Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan; 
   [CFRPG8K0011];  [CMRPG8M0381];  [CMRPG8N0171];  [CMRPG8M0721]; 
   [CORPG8L0551];  [CORPG8P0031]
FX Work reported herein is carried out with financial support from
   Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan, under grants
   CFRPG8K0011, CMRPG8M0381, CMRPG8N0171, CMRPG8M0721, CORPG8L0551 and
   CORPG8P0031.
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NR 170
TC 5
Z9 5
U1 6
U2 7
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD SEP
PY 2024
VL 16
IS 18
AR 3168
DI 10.3390/nu16183168
PG 22
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA H5C1R
UT WOS:001323609600001
PM 39339768
OA gold
DA 2025-06-11
ER

PT J
AU Bhowmick, S
   Singh, V
   Jash, S
   Lal, M
   Roy, SS
AF Bhowmick, Snigdha
   Singh, Vandana
   Jash, Sandipan
   Lal, Megha
   Roy, Soumya Sinha
TI Mitochondrial metabolism and calcium homeostasis in the development of
   NAFLD leading to hepatocellular carcinoma
SO MITOCHONDRION
LA English
DT Article
DE Hepatocytes; Mitochondria; Mitochondrial calcium; NAFLD; HCC
ID NONALCOHOLIC FATTY LIVER; ENDOPLASMIC-RETICULUM; OXIDATIVE STRESS;
   ESSENTIAL COMPONENT; HEPATIC STEATOSIS; REACTIVE OXYGEN; DYSFUNCTION;
   EXPRESSION; MEMBRANE; GLUCOSE
AB Non-alcoholic fatty liver disease (NAFLD) is a metabolic syndrome characterized by excessive accumulation of hepatic lipid droplets. The disease progresses with steatosis as the premise for hepatocytic damage and tissue scarring, often culminating in hepatocellular carcinoma (HCC). Perturbations in mitochondrial metabolism and energetics were found to be associated with, and often instrumental in various stages of this progression. Functional impairment of the mitochondria affects all aspects of cellular functioning and a particularly important one is calcium signalling. Changes in mitochondrial calcium specifically in hepatocytes of a fatty liver, is reflected by alterations in calcium signalling as well as calcium transporter activities. This deranged Ca2+ homeostasis aids in even more uptake of lipids into the mitochondria and a shift in equilibrium, both metabolically as well as in terms of energy production, leading to completely altered cellular states. These alterations have been reviewed as a perspective to understand the disease progression through NAFLD leading to HCC.
C1 [Bhowmick, Snigdha; Singh, Vandana; Jash, Sandipan; Lal, Megha; Roy, Soumya Sinha] CSIR Inst Genom & Integrat Biol, Mathura Rd, New Delhi 110020, India.
   Acad Sci & Innovat Res, Ghaziabad 201002, India.
C3 Council of Scientific & Industrial Research (CSIR) - India; CSIR -
   Institute of Genomics & Integrative Biology (IGIB); Academy of
   Scientific & Innovative Research (AcSIR)
RP Bhowmick, S; Roy, SS (corresponding author), CSIR Inst Genom & Integrat Biol, Mathura Rd, New Delhi 110020, India.
EM snigdha.b@igib.in; soumya.roy@igib.res.in
RI Lal, Megha/ABG-6800-2021; Singh, Vandana/IQV-5543-2023
OI Bhowmick, Snigdha/0000-0002-6691-3916; Lal, Megha/0000-0002-9235-7255;
   Singh, Vandana/0000-0002-0353-6498; Sinha Roy,
   Soumya/0000-0002-4135-0141
FU Council of Scientific and Industrial Research (CSIR) , India [MLP138];
   Department of Biotechnology (DBT) , India; University Grants Commission
   (UGC) , India
FX This work was supported by the Council of Scientific and Industrial
   Research (CSIR) , India through grant (MLP138) . VS and SJ are supported
   by the fellowship from the Department of Biotechnology (DBT) , India and
   the University Grants Commission (UGC) , India respectively.
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NR 141
TC 13
Z9 13
U1 2
U2 12
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 1567-7249
EI 1872-8278
J9 MITOCHONDRION
JI Mitochondrion
PD MAY
PY 2021
VL 58
BP 24
EP 37
DI 10.1016/j.mito.2021.01.007
EA FEB 2021
PG 14
WC Cell Biology; Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Genetics & Heredity
GA RY1IU
UT WOS:000647670900003
PM 33581332
DA 2025-06-11
ER

PT J
AU Moghaddam, RH
   Samimi, Z
   Moradi, SZ
   Little, PJ
   Xu, SW
   Farzaei, MH
AF Moghaddam, Reza Heidary
   Samimi, Zeinab
   Moradi, Seyed Zachariah
   Little, Peter J.
   Xu, Suowen
   Farzaei, Mohammad Hosein
TI Naringenin and naringin in cardiovascular disease prevention: A
   preclinical review
SO EUROPEAN JOURNAL OF PHARMACOLOGY
LA English
DT Review
DE Cardiovascular disease; Vasculature; Natural phytochemicals; Naringin;
   Naringenin; Anti-Oxidative
ID ISCHEMIA-REPERFUSION INJURY; ENDOTHELIAL DYSFUNCTION; CITRUS FLAVONOIDS;
   NITRIC-OXIDE; IN-VITRO; MYOCARDIAL-INFARCTION; GRAPEFRUIT JUICE;
   OXIDATIVE STRESS; PATHWAY; ATHEROSCLEROSIS
AB Cardiovascular disease is an important cause for morbidity and mortality worldwide. Flavonoids, such as naringin, and naringenin are important natural phytochemicals in the treatment or prevention of various disorders such as obesity, cardiac diseases, diabetes, and metabolic syndrome. Naringin and naringenin have significant therapeutic potential in several diseases through anti-oxidative, anti-inflammatory, and anti-apoptotic actions; these flavonoids play a protective role in human pathophysiology. In this review, based on the latest evidence, we present a summary of the impact of naringin, and naringenin on cardiovascular disease, and analyze and discuss the basic roles of naringin and naringenin and their mechanisms of actions in cardiovascular disease and other vascular dysfunction. The data collected in this review may serve as a comprehensive reference for the effects of naringin, and naringenin in cardiovascular disease, which may be beneficial for further research and for the design of naringin and naringenin analogs as new therapeutic options for cardiovascular diseases.
C1 [Moghaddam, Reza Heidary] Kermanshah Univ Med Sci, Clin Res Dev Ctr, Imam Ali & Taleghani Hosp, Kermanshah, Iran.
   [Samimi, Zeinab; Moradi, Seyed Zachariah; Farzaei, Mohammad Hosein] Kermanshah Univ Med Sci, Hlth Inst, Pharmaceut Sci Res Ctr, Kermanshah 6734667149, Iran.
   [Moradi, Seyed Zachariah; Farzaei, Mohammad Hosein] Kermanshah Univ Med Sci, Med Biol Res Ctr, Hlth Technol Inst, Kermanshah 6734667149, Iran.
   [Little, Peter J.] Sun Yat Sen Univ, Dept Pharm, Xinhua Coll, Guangzhou 510520, Peoples R China.
   [Little, Peter J.] Univ Queensland, Sch Pharm, Pharm Australia Ctr Excellence, Woollsiana, Qld 4102, Australia.
   [Xu, Suowen] Univ Sci & Technol China, Dept Endocrinol & Metab, Affiliated Hosp 1, USTC,Div Life Sci & Med, Hefei 230037, Peoples R China.
C3 Kermanshah University of Medical Sciences; Kermanshah University of
   Medical Sciences; Kermanshah University of Medical Sciences; Sun Yat Sen
   University; University of Queensland; Chinese Academy of Sciences;
   University of Science & Technology of China, CAS
RP Farzaei, MH (corresponding author), Kermanshah Univ Med Sci, Hlth Inst, Pharmaceut Sci Res Ctr, Kermanshah 6734667149, Iran.; Xu, SW (corresponding author), Univ Sci & Technol China, Dept Endocrinol & Metab, Affiliated Hosp 1, USTC,Div Life Sci & Med, Hefei 230037, Peoples R China.
EM sxu1984@ustc.edu.cn; mh.farzaei@gmail.com
RI Farzaei, Mohammad/M-5779-2017; Little, Peter/F-9865-2015; Xu,
   Suowen/H-8697-2019; Moradi, Seyed Zachariah/ABA-9171-2020
OI Xu, Suowen/0000-0002-5488-5217; Reis, AlessanRSS/0000-0001-8486-7469;
   Moradi, Seyed Zachariah/0000-0003-0579-3495; Samimi,
   Zeinab/0000-0003-4398-9288
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NR 91
TC 157
Z9 159
U1 4
U2 82
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0014-2999
EI 1879-0712
J9 EUR J PHARMACOL
JI Eur. J. Pharmacol.
PD NOV 15
PY 2020
VL 887
AR 173535
DI 10.1016/j.ejphar.2020.173535
PG 9
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA OH6SG
UT WOS:000582725000019
PM 32910944
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Asif, H
   Alamgeer
   Bukhari, IA
   Vohra, F
   Afzal, S
   Khan, SW
   Niazig, ZR
AF Asif, Hira
   Alamgeer
   Bukhari, Ishfaq Ali
   Vohra, Fahim
   Afzal, Sibtain
   Khan, Sher Wali
   Niazig, Zahid Rasul
TI Phytochemical analysis of crude extract of Delphinium brunonianum
   and its effect on hypertension and metabolic perturbations in fructose
   fed rats
SO NATURAL PRODUCT RESEARCH
LA English
DT Article
DE Delphinium brunonianum; hypertension; metabolic syndrome; oxidative
   stress; LC-MS analysis
ID ASCORBIC-ACID; ANTIOXIDANT; WEIGHT
AB The present study aims at phytochemical profiling and valuating the effect of crude extract of Delphinium brunonianum on fructose mediated rise in blood pressure and metabolic abnormalities in rats. Therefore, rats were fed on fructose (10%w/v) for 6 weeks. Rats in treatment groups received amlodipine 250, 500 and 1000 mg/kg of DB-Cr separately in concurrent to fructose. Various parameters of metabolic perturbations were assessed at the end of study. Further, DB-Cr was analyzed using LC-MS technique. DB-Cr exerted remarkable antihypertensive effect whereas, sympathetic hyperactivity and hyperinsulinemia in these rats was significantly blunted, further, endothelium functionality was successfully restored. LC-MS analysis of DB-Cr revealed the presence of a variety of chemical constituents (41) including quinic acid, scopolin, gingerol, Robinetin 3-rutinoside, KAPA and maleic acid. In conclusion, D. brunonianum possess the potential to combat the fructose mediated hypertension and metabolic perturbations, which may partially be due to its chemical constituents.
C1 [Asif, Hira; Alamgeer] Univ Sargodha, Coll Pharm, Dept Pharmacol, Lab Cardiovasc Res & Integrat Pharmacol, Sargodha, Pakistan.
   [Asif, Hira] Univ Lahore, Dept Pharm, Gujrat Campus, Gujranwala, Punjab, Pakistan.
   [Bukhari, Ishfaq Ali] King Saud Univ, Coll Med, Dept Pharmacol, Riyadh, Saudi Arabia.
   [Vohra, Fahim] King Saud Univ, Coll Dent, Dept Prosthet Dent Sci, Riyadh, Saudi Arabia.
   [Afzal, Sibtain] King Saud Univ, Coll Med, Immunol Res Ctr, Riyadh, Saudi Arabia.
   [Khan, Sher Wali] Karakoram Int Univ, Dept Biol Sci, Gilgit, Gilgit Baltista, Pakistan.
   [Niazig, Zahid Rasul] Gomal Univ DI Khan, Fac Pharm, Dept Basic Med Sci, Dera Ismail Khan, Pakistan.
C3 University of Sargodha; King Saud University; King Saud University; King
   Saud University; Karakoram International University; Gomal University
RP Alamgeer (corresponding author), Univ Sargodha, Coll Pharm, Dept Pharmacol, Lab Cardiovasc Res & Integrat Pharmacol, Sargodha, Pakistan.
EM alam_yuchi@yahoo.com
RI Alamgeer/K-8284-2019; Asif, Dr. Hira/J-7340-2016; Vohra,
   Fahim/E-6506-2017
OI bukhari, ishfaq/0000-0002-5671-2395; Rasul, Zahid/0000-0001-8527-3857;
   AFZAL, SIBTAIN/0000-0002-9174-6590; Asif, Dr. Hira/0000-0002-3027-4518;
   -, Dr Alamgeer/0000-0003-4775-7337
FU Deanship of Scientific Research at King Saud University [RG-1439-002]
FX The authors extend their appreciation to the Deanship of Scientific
   Research at King Saud University for funding this work through research
   group NO (RG-1439-002).
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NR 21
TC 5
Z9 5
U1 1
U2 19
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1478-6419
EI 1478-6427
J9 NAT PROD RES
JI Nat. Prod. Res.
PD AUG 19
PY 2021
VL 35
IS 17
BP 2982
EP 2986
DI 10.1080/14786419.2019.1679134
EA OCT 2019
PG 5
WC Chemistry, Applied; Chemistry, Medicinal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Pharmacology & Pharmacy
GA UK2TM
UT WOS:000493599600001
PM 31674843
DA 2025-06-11
ER

PT J
AU Chen, C
   Liu, Q
   Liu, L
   Hu, YY
   Feng, Q
AF Chen, Cheng
   Liu, Qian
   Liu, Lin
   Hu, Yi-yang
   Feng, Qin
TI Potential Biological Effects of (-)-Epigallocatechin-3-gallate on the
   Treatment of Nonalcoholic Fatty Liver Disease
SO MOLECULAR NUTRITION & FOOD RESEARCH
LA English
DT Review
DE (-)-epigallocatechin-3-gallate; catechins; fatty liver; nonalcoholic
   fatty liver disease(NAFLD); nonalcoholic steatohepatitis (NASH)
ID GREEN TEA POLYPHENOL; CONTROLLED CLINICAL-TRIAL; ACTIVATED
   PROTEIN-KINASE; RECEPTOR-DEFICIENT MICE; DIET-INDUCED OBESITY;
   EPIGALLOCATECHIN GALLATE; METABOLIC SYNDROME; INSULIN-RESISTANCE;
   HEPATIC STEATOSIS; OXIDATIVE STRESS
AB Nonalcoholic fatty liver disease (NAFLD) is a major health issue throughout the world. However, no validated treatments for NAFLD are currently available. In-depth studies have demonstrated the efficacy of (-)-epigallocatechin-3-gallate (EGCG), a main bioactive chemical extracted from green tea, in treating NAFLD. EGCG exhibits multi-pronged preventive and therapeutic activities, including promoting lipid and glucose metabolism, anti-lipid peroxidation and anti-inflammation activities, anti-fibrosis, and anti-NAFLD related tumor, thus contributing to the mitigation of NAFLD occurrence and progression. The objectives of this paper are to review and discuss the currently known targets, signaling pathways and roles of EGCG that interfere with NAFLD pathogenesis, then providing additional experimental evidence and the foundation for the further studies and clinical applications of EGCG in the prevention and treatment of NAFLD.
C1 [Chen, Cheng; Liu, Qian; Liu, Lin; Hu, Yi-yang; Feng, Qin] Shanghai Univ Tradit Chinese Med, Shuguang Hosp, Inst Liver Dis, Shanghai, Peoples R China.
   [Hu, Yi-yang] Shanghai Key Lab Tradit Chinese Clin Med, Shanghai, Peoples R China.
   [Hu, Yi-yang] E Inst Shanghai Municipal Educ Comm, Shanghai, Peoples R China.
C3 Shanghai University of Traditional Chinese Medicine; Shanghai Municipal
   Education Commission (SHMEC)
RP Hu, YY; Feng, Q (corresponding author), Shanghai Univ Tradit Chinese Med, Shuguang Hosp, Inst Liver Dis, Shanghai, Peoples R China.; Hu, YY (corresponding author), Shanghai Key Lab Tradit Chinese Clin Med, Shanghai, Peoples R China.; Hu, YY (corresponding author), E Inst Shanghai Municipal Educ Comm, Shanghai, Peoples R China.
EM yyhuliver@163.com; fengqin1227@163.com
OI Chen, Cheng/0000-0001-8024-5128
FU National Natural Science Foundation of China [81573668, 81374031,
   81673765]
FX This work was supported by the National Natural Science Foundation of
   China (No. 81573668, No. 81374031, to Q. F.; No. 81673765, to Y.H.)
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NR 85
TC 56
Z9 60
U1 4
U2 56
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1613-4125
EI 1613-4133
J9 MOL NUTR FOOD RES
JI Mol. Nutr. Food Res.
PD JAN
PY 2018
VL 62
IS 1
AR 1700483
DI 10.1002/mnfr.201700483
PG 11
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA FS4AI
UT WOS:000419727500009
PM 28799714
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Lucas-Herald, AK
   Alves-Lopes, R
   Montezano, AC
   Ahmed, SF
   Touyz, RM
AF Lucas-Herald, Angela K.
   Alves-Lopes, Rheure
   Montezano, Augusto C.
   Ahmed, S. Faisal
   Touyz, Rhian M.
TI Genomic and non-genomic effects of androgens in the cardiovascular
   system: clinical implications
SO CLINICAL SCIENCE
LA English
DT Review
ID VASCULAR SMOOTH-MUSCLE; LOW TESTOSTERONE LEVELS; HYDROGEN-SULFIDE;
   OXIDATIVE STRESS; ENDOTHELIAL DYSFUNCTION; CAROTID ATHEROSCLEROSIS;
   HORMONAL-REGULATION; METABOLIC SYNDROME; PENILE ERECTION;
   SEX-DIFFERENCES
AB The principle steroidal androgens are testosterone and its metabolite 5 alpha-dihydrotestosterone (DHT), which is converted from testosterone by the enzyme 5 alpha-reductase. Through the classic pathway with androgens crossing the plasma membrane and binding to the androgen receptor (AR) or via mechanisms independent of the ligand-dependent transactivation function of nuclear receptors, testosterone induces genomic and non-genomic effects respectively. AR is widely distributed in several tissues, including vascular endothelial and smooth muscle cells. Androgens are essential for many developmental and physiological processes, especially in male reproductive tissues. It is now clear that androgens have multiple actions besides sex differentiation and sexual maturation and that many physiological systems are influenced by androgens, including regulation of cardiovascular function [nitric oxide (NO) release, Ca2+ mobilization, vascular apoptosis, hypertrophy, calcification, senescence and reactive oxygen species (ROS) generation]. This review focuses on evidence indicating that interplay between genomic and non-genomic actions of testosterone may influence cardiovascular function.
C1 [Lucas-Herald, Angela K.; Ahmed, S. Faisal] Queen Elizabeth Univ, Dev Endocrinol Res Grp, Hosp Campus,1345 Govan Rd, Glasgow G51 4TF, Lanark, Scotland.
   [Lucas-Herald, Angela K.; Alves-Lopes, Rheure; Montezano, Augusto C.; Touyz, Rhian M.] Univ Glasgow, British Heart Fdn Glasgow Cardiovasc Res Ctr, Inst Cardiovasc & Med Sci, 126 Univ Pl, Glasgow G12 8TA, Lanark, Scotland.
C3 University of Glasgow
RP Touyz, RM (corresponding author), Univ Glasgow, British Heart Fdn Glasgow Cardiovasc Res Ctr, Inst Cardiovasc & Med Sci, 126 Univ Pl, Glasgow G12 8TA, Lanark, Scotland.
EM Rhian.touyz@glasgow.ac.uk
RI Lucas-Herald, Angela/HLH-7405-2023; Touyz, Rhian/AAM-3564-2020;
   Alves-Lopes, Rheure/U-7347-2018
OI Alves-Lopes, Rheure/0000-0002-4885-6647; Lucas-Herald,
   Angela/0000-0003-2662-1684
FU British Heart Foundation (BHF) [RE/13/5/30177]; BHF Chair
   [CH/12/4/29762]; MRC [MR/N003403/1] Funding Source: UKRI
FX This work was supported by the British Heart Foundation (BHF) [grant
   number RE/13/5/30177 (to A.K.L.H., R.A.-L., A.C.M. and R.M.T.)]; and a
   BHF Chair [grant number CH/12/4/29762 (to R.M.T.)].
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   Rech CMZ, 2016, EUR J ENDOCRINOL, V174, P297, DOI 10.1530/EJE-15-0878
NR 126
TC 85
Z9 95
U1 1
U2 10
PU PORTLAND PRESS LTD
PI LONDON
PA CHARLES DARWIN HOUSE, 12 ROGER STREET, LONDON WC1N 2JU, ENGLAND
SN 0143-5221
EI 1470-8736
J9 CLIN SCI
JI Clin. Sci.
PD JUL 1
PY 2017
VL 131
IS 13
BP 1405
EP 1418
DI 10.1042/CS20170090
PG 14
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA FB2QS
UT WOS:000405988900003
PM 28645930
OA hybrid, Green Accepted, Green Published
DA 2025-06-11
ER

PT J
AU Reimann, M
   Schutte, AE
   Schwarz, PEH
AF Reimann, M.
   Schutte, A. E.
   Schwarz, P. E. H.
TI Insulin resistance - The role of ethnicity: Evidence from Caucasian and
   African cohorts
SO HORMONE AND METABOLIC RESEARCH
LA English
DT Review
DE insulin resistance; ethnicity; African population; obesity; urbanization
ID METABOLIC SYNDROME; DIABETES PREVENTION; SOUTH-AFRICA; RISK-FACTORS;
   ADIPOQ GENE; OBESITY; HEALTH; URBANIZATION; DISEASE; STRESS
AB The risk for insulin resistance and subsequent type 2 diabetes varies between different ethnic populations due to differences in the genetic and environmental background. However, obesity and unhealthy lifestyle, crucial determinants of insulin resistance, are on the rise throughout all population groups though the susceptibility towards those factors may differ. Up to the present day it is not clear whether insulin resistance is based on metabolic changes due to lifestyle modifications or rather an ethnic and thus genetic grounded phenomenon. Genetic variations in secretion products of the active fat tissue (adipokines), a different pathophysiology of changes in glucose metabolism and the deep impact of urbanization (environmental factors) are discussed as primary determinants for differences in manifestation of insulin resistance between Caucasian and African populations. These factors may be influenced or modified by a central theme: visceral obesity. This mini review will elaborate on these issues illustrated by observations from Caucasian and African cohorts.
C1 [Reimann, M.; Schwarz, P. E. H.] Tech Univ Dresden, Med Fac Carl Gustav Carus, Clin Endocrinol Diabet & Metab, Dept Internal Med 3, D-01307 Dresden, Germany.
   [Schutte, A. E.] NW Univ Potchefstroom Campus, Sch Physiol Nutr & Consumer Sci, Potchefstroom, South Africa.
C3 Technische Universitat Dresden; Carl Gustav Carus University Hospital;
   North West University - South Africa
RP Schwarz, PEH (corresponding author), Tech Univ Dresden, Med Fac Carl Gustav Carus, Dept Med 3, Div Endocrinol, D-01307 Dresden, Germany.
EM peter.schwarz@uniklinikum-dresden.de
RI Schutte, Aletta/E-5126-2018
OI Schutte, Aletta/0000-0001-9217-4937
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NR 64
TC 23
Z9 26
U1 0
U2 3
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0018-5043
EI 1439-4286
J9 HORM METAB RES
JI Horm. Metab. Res.
PD DEC
PY 2007
VL 39
IS 12
BP 853
EP 857
DI 10.1055/s-2007-993152
PG 5
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 251GL
UT WOS:000252360500001
PM 18075967
DA 2025-06-11
ER

PT J
AU Aziz, N
   Wal, P
   Sinha, R
   Shirode, PR
   Chakraborthy, G
   Sharma, MC
   Kumar, P
AF Aziz, Namra
   Wal, Pranay
   Sinha, Rishika
   Shirode, Prashant Ramesh
   Chakraborthy, Gunosindhu
   Sharma, Mukesh Chandra
   Kumar, Pankaj
TI A Comprehensive Review on the Significance of Cysteine in Various
   Metabolic Disorders; Particularly CVD, Diabetes, Renal Dysfunction, and
   Ischemic Stroke
SO CURRENT PROTEIN & PEPTIDE SCIENCE
LA English
DT Review
DE Cysteine; metabolic disorders; diabetes mellitus; renal dysfunction;
   ischemic stroke; reactive oxygen species; cardiovascular disorders
ID ORAL N-ACETYLCYSTEINE; OXIDATIVE STRESS; ENDOTHELIAL DYSFUNCTION;
   MYOCARDIAL-INFARCTION; REACTIVE OXYGEN; CARDIAC-SURGERY; DOUBLE-BLIND;
   AMINO-ACIDS; ANTIOXIDANT; KIDNEY
AB Metabolic disorders have long been a challenge for medical professionals and are a leading cause of mortality in adults. Diabetes, cardiovascular disorders (CVD), renal dysfunction, and ischemic stroke are the most prevalent ailments contributing to a high mortality rate worldwide. Reactive oxygen species are one of the leading factors that act as a fundamental root cause of metabolic syndrome. All of these disorders have their respective treatments, which, to some degree, sabotage the pathological worsening of the disease and an inevitable death. However, they pose a perilous health hazard to humankind. Cysteine, a functional amino acid shows promise for the prevention and treatment of metabolic disorders, such as CVD, Diabetes mellitus, renal dysfunction, and ischemic stroke. In this review, we explored whether cysteine can eradicate reactive oxygen species and subsequently prevent and treat these diseases.
C1 [Aziz, Namra; Wal, Pranay; Sinha, Rishika] PSIT Pranveer Singh Inst Technol Pharm, NH-19, Kanpur 209305, Uttar Pradesh, India.
   [Shirode, Prashant Ramesh] KK Wagh Coll Pharm, KK Wagh Educ Soc, Nasik 422003, India.
   [Chakraborthy, Gunosindhu] Parul Univ, Parul Inst Pharm & Res, Vadodara, India.
   [Sharma, Mukesh Chandra] Devi Ahilya Vishwavidalaya, Sch Pharm, Indore 452001, India.
   [Kumar, Pankaj] Adesh 6 Univ, Adesh Inst Pharm & Biomed Sci, Dept Pharmacol, NH-7, Barnala Rd, Bathinda 151001, India.
C3 Parul University; Parul Institute of Pharmacy & Research; Devi Ahilya
   University
RP Kumar, P (corresponding author), Adesh 6 Univ, Adesh Inst Pharm & Biomed Sci, Dept Pharmacol, NH-7, Barnala Rd, Bathinda 151001, India.
EM drprankaj321@gmail.com
RI Wal, Dr Pranay/ABA-7278-2021; Chakraborthy, Guno/R-9455-2019; Sharma, Dr
   Mukesh/I-3946-2019; Kumar, Pankaj/AAD-2135-2019
OI Aziz, Namra/0000-0003-1774-1043; Sinha, Rishika/0009-0007-1222-0042
FX We would like to thank Dr. A. K. Rai, Director, PSIT (Pharmacy) for his
   motivation and support.
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NR 139
TC 0
Z9 0
U1 2
U2 2
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1389-2037
EI 1875-5550
J9 CURR PROTEIN PEPT SC
JI Curr. Protein Pept. Sci.
PY 2024
VL 25
IS 9
BP 682
EP 707
DI 10.2174/0113892037287215240424090908
PG 26
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA D2G1Z
UT WOS:001294413900003
PM 38766817
DA 2025-06-11
ER

PT J
AU Pinheiro-Machado, E
   Gurgul-Convey, E
   Marzec, MT
AF Pinheiro-Machado, Erika
   Gurgul-Convey, Ewa
   Marzec, Michal T.
TI Immunometabolism in type 2 diabetes mellitus: tissue-specific
   interactions
SO ARCHIVES OF MEDICAL SCIENCE
LA English
DT Article
DE immunity; metabolism; tissue-specific; diabetes
ID ENDOPLASMIC-RETICULUM STRESS; HIGH-FAT-DIET; INDUCED INSULIN-RESISTANCE;
   INNATE LYMPHOID-CELLS; PRORESOLVING LIPID MEDIATORS; ADIPOSE-TISSUE;
   SKELETAL-MUSCLE; T-CELLS; GUT MICROBIOTA; METABOLIC SYNDROME
AB The immune system is frequently described in the context of its protective function against infections and its role in the development of autoimmunity. For more than a decade, the interactions between the immune system and metabolic processes have been reported, in effect creating a new research field, termed immunometabolism. Accumulating evidence supports the hypo thesis that the development of metabolic diseases may be linked to inflammation, and reflects, in some cases, the activation of immune responses. As such, immunometabolism is defined by 1) inflammation as a driver of disease development and/or 2) metabolic processes stimulating cellular differentiation of the immune components. In this review, the main factors capable of altering the immuno-metabolic communication leading to the development and establishment of obesity and diabetes are comprehensively presented. Tissue-specific immune responses suggested to impair metabolic processes are described, with an emphasis on the adipose tissue, gut, muscle, liver, and pancreas.
C1 [Pinheiro-Machado, Erika; Marzec, Michal T.] Univ Med Ctr Groningen, Dept Pathol & Med Biol, Groningen, Netherlands.
   [Gurgul-Convey, Ewa; Marzec, Michal T.] Hannover Med Sch, Inst Clin Biochem, Hannover, Germany.
   [Marzec, Michal T.] Univ Copenhagen, Dept Biomed Sci, Copenhagen, Denmark.
   [Marzec, Michal T.] Univ Copenhagen, Panum Inst, Dept Biomed Sci, Room 12-6-10,Blegdamsvej 3, DK-2200 Copenhagen N, Denmark.
C3 University of Groningen; Hannover Medical School; University of
   Copenhagen; University of Copenhagen
RP Marzec, MT (corresponding author), Univ Copenhagen, Panum Inst, Dept Biomed Sci, Room 12-6-10,Blegdamsvej 3, DK-2200 Copenhagen N, Denmark.
EM Michal@sund.ku.dk
RI Marzec, Michal/O-6387-2016
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NR 278
TC 9
Z9 9
U1 1
U2 7
PU TERMEDIA PUBLISHING HOUSE LTD
PI POZNAN
PA KLEEBERGA 2, POZNAN, 61-615, POLAND
SN 1734-1922
EI 1896-9151
J9 ARCH MED SCI
JI Arch. Med. Sci.
PY 2023
VL 19
IS 4
BP 895
EP 911
DI 10.5114/aoms.2020.92674
PG 17
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA M9UI7
UT WOS:001033588000004
PM 37560741
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Wang, WW
   Pan, Y
   Zhou, H
   Wang, L
   Chen, X
   Song, G
   Liu, JX
   Li, AK
AF Wang, Weiwei
   Pan, Yiou
   Zhou, Hang
   Wang, Li
   Chen, Xi
   Song, Ge
   Liu, Jianxue
   Li, Aike
TI Ferulic acid suppresses obesity and obesity-related metabolic syndromes
   in high fat diet-induced obese C57BL/6J mice
SO FOOD AND AGRICULTURAL IMMUNOLOGY
LA English
DT Article
DE Ferulic acid; high-fat diet; metabolic syndrome; mice; obesity
ID OXIDATIVE STRESS; LIVER; RATS; ORYZANOL; DISEASE; BETA
AB This study aimed to determine whether mice fed ferulic acid (FA) would alleviate high-fat diet-induced obesity and obesity-related metabolic syndromes. Mice were divided into the following four groups and fed for 6 wk (n = 8): control diet (NC), high-fat diet (HF; 60% energy from fat), NC and HF supplemented with 0.5% (w/w) FA respectively. Mice fed HF-FA diet consumed same amount of energy, but had lower daily weight gain, white adipose tissue weight, body fat accumulation, blood glucose and had suppressed hepatic lipid accumulation and inflammatory cytokines (IL-6 and TNF-alpha) release (P<0.05), compared with those in HF-fed mice. In conclusion, our findings indicate that dietary FA supplementation suppress body weight gain, body and hepatic fat accumulation, blood glucose elevation and inflammation in high fat diet-induced obese mice, suggesting that FA could be effective in lowering the risk of high fat-diet induced obesity and obesity-related metabolic syndromes.
C1 [Wang, Weiwei; Pan, Yiou; Zhou, Hang; Wang, Li; Chen, Xi; Song, Ge; Li, Aike] Acad State Adm Grain, Beijing 100037, Peoples R China.
   [Pan, Yiou; Liu, Jianxue] Henan Univ Sci & Technol, Luoyang, Peoples R China.
C3 Henan University of Science & Technology
RP Li, AK (corresponding author), Acad State Adm Grain, Beijing 100037, Peoples R China.
EM lak@chinagrain.org
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NR 28
TC 29
Z9 32
U1 0
U2 50
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0954-0105
EI 1465-3443
J9 FOOD AGR IMMUNOL
JI Food Agric. Immunol.
PY 2018
VL 29
IS 1
BP 1116
EP 1125
DI 10.1080/09540105.2018.1516739
PG 10
WC Chemistry, Applied; Food Science & Technology; Immunology; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Food Science & Technology; Immunology; Toxicology
GA GW9UO
UT WOS:000447350500004
OA gold
DA 2025-06-11
ER

PT J
AU Gluchowski, NL
   Becuwe, M
   Walther, TC
   Farese, RV
AF Gluchowski, Nina L.
   Becuwe, Michel
   Walther, Tobias C.
   Farese, Robert V., Jr.
TI Lipid droplets and liver disease: from basic biology to clinical
   implications
SO NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
LA English
DT Review
ID HEPATITIS-C VIRUS; ADIPOSE TRIGLYCERIDE LIPASE; DIACYLGLYCEROL
   ACYLTRANSFERASE 1; HORMONE-SENSITIVE LIPASE; COA-CHOLESTEROL
   ACYLTRANSFERASE; ENDOPLASMIC-RETICULUM STRESS; INDUCED
   INSULIN-RESISTANCE; LOW-DENSITY LIPOPROTEINS; GENOME-WIDE ASSOCIATION;
   FATTY-ACID TRAFFICKING
AB Lipid droplets are dynamic organelles that store neutral lipids during times of energy excess and serve as an energy reservoir during deprivation. Many prevalent metabolic diseases, such as the metabolic syndrome or obesity, often result in abnormal lipid accumulation in lipid droplets in the liver, also called hepatic steatosis. Obesity-related steatosis, or NAFLD in particular, is a major public health concern worldwide and is frequently associated with insulin resistance and type 2 diabetes mellitus. Here, we review the latest insights into the biology of lipid droplets and their role in maintaining lipid homeostasis in the liver. We also offer a perspective of liver diseases that feature lipid accumulation in these lipid storage organelles, which include NAFLD and viral hepatitis. Although clinical applications of this knowledge are just beginning, we highlight new opportunities for identifying molecular targets for treating hepatic steatosis and steatohepatitis.
C1 [Gluchowski, Nina L.; Becuwe, Michel; Walther, Tobias C.; Farese, Robert V., Jr.] Harvard TH Chan Sch Publ Hlth, Dept Genet & Complex Dis, 655 Huntington Ave, Boston, MA 02115 USA.
   [Gluchowski, Nina L.] Boston Childrens Hosp, Dept Gastroenterol Hepatol & Nutr, 300 Longwood Ave, Boston, MA 02115 USA.
   [Walther, Tobias C.; Farese, Robert V., Jr.] Harvard Med Sch, Dept Cell Biol, 240 Longwood Ave, Boston, MA 02115 USA.
   [Walther, Tobias C.; Farese, Robert V., Jr.] Harvard Med Sch, Dept Genet, 77 Ave Louis Pasteur, Boston, MA 02115 USA.
   [Walther, Tobias C.] Harvard TH Chan Sch Publ Hlth, Dept Genet & Complex Dis, Howard Hughes Med Inst, 655 Huntington Ave, Boston, MA 02115 USA.
C3 Harvard University; Harvard T.H. Chan School of Public Health; Harvard
   University; Harvard University Medical Affiliates; Boston Children's
   Hospital; Harvard University; Harvard Medical School; Harvard
   University; Harvard Medical School; Harvard University; Harvard T.H.
   Chan School of Public Health; Howard Hughes Medical Institute
RP Walther, TC; Farese, RV (corresponding author), Harvard TH Chan Sch Publ Hlth, Dept Genet & Complex Dis, 655 Huntington Ave, Boston, MA 02115 USA.
EM robert@hsph.harvard.edu; twalther@hsph.harvard.ed
RI Farese, Robert/B-3605-2015
OI Walther, Tobias/0000-0003-1442-1327
FU NIH National Institute of General Medical Sciences [R01 GM099844, R01
   GM097194]; NIH National Institute of Diabetes and Digestive and Kidney
   Diseases [R01 DK056084, R01 DK101579]; Jane Coffin Childs Foundation
FX We thank S. Alexandrescu for the pathology images in Figure 2, and G.
   Howard for editorial assistance. R.V.F. acknowledges support from NIH
   National Institute of General Medical Sciences R01 GM099844, NIH
   National Institute of Diabetes and Digestive and Kidney Diseases R01
   DK056084 and R01 DK101579. T.C.W. acknowledges support from NIH National
   Institute of General Medical Sciences R01 GM097194. T.C.W. is an
   investigator of the Howard Hughes Medical Institute. M.B. is supported
   by a fellowship from the Jane Coffin Childs Foundation.
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NR 201
TC 493
Z9 547
U1 16
U2 225
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 1759-5045
EI 1759-5053
J9 NAT REV GASTRO HEPAT
JI Nat. Rev. Gastroenterol. Hepatol.
PD JUN
PY 2017
VL 14
IS 6
BP 343
EP 355
DI 10.1038/nrgastro.2017.32
PG 13
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA EV9OV
UT WOS:000402116200006
PM 28428634
OA Green Accepted
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Gotoh, K
   Fujiwara, K
   Anai, M
   Okamoto, M
   Masaki, T
   Kakuma, T
   Shibata, H
AF Gotoh, Koro
   Fujiwara, Kansuke
   Anai, Manabu
   Okamoto, Mitsuhiro
   Masaki, Takayuki
   Kakuma, Tetsuya
   Shibata, Hirotaka
TI Role of spleen-derived IL-10 in prevention of systemic low-grade
   inflammation by obesity
SO ENDOCRINE JOURNAL
LA English
DT Review
DE Obesity; Spleen; IL-10; Inflammation
ID INDUCED INSULIN-RESISTANCE; ANTIINFLAMMATORY ROLE; METABOLIC SYNDROME;
   INTERLEUKIN-10; LIVER; DIET; EXPRESSION; RATS; STEATOSIS; CYTOKINES
AB Obesity can be associated with systemic low-grade inflammation that leads to obesity-related metabolic disorders. Recent studies raise the possibility that the inflammation in hypothalamus, liver and white adipose tissue (WAT) contributes to the pathogenesis of diet-induced obesity. We focus on the role of interleukin (IL)-10, an anti-inflammatory cytokine produced from spleen in obesity because it is indicated that obesity decreases the expression of pro-inflammatory cytokines in spleen. Obesity results in decrease of IL-10 synthesis from spleen, probably due to reduction of B-cells expression by promoting oxidative stress and apoptosis in spleen. Splenectomy (SPX) aggravates the inflammatory response in hypothalamus, liver and WAT. These SPX-induced alterations are inhibited by systemic administration of IL 10. Moreover, in IL-10 deficiency, SPX had little effect on the inflammatory responses in these multiple organs. We show the role of spleen-derived IL-10 on inflammatory responses in obesity.
C1 [Gotoh, Koro; Fujiwara, Kansuke; Anai, Manabu; Okamoto, Mitsuhiro; Masaki, Takayuki; Kakuma, Tetsuya; Shibata, Hirotaka] Oita Univ, Dept Endocrinol Metab Rheumatol & Nephrol, Fac Med, 1-1 Idaigaoka, Yufu City, Oita 8795593, Japan.
C3 Oita University
RP Gotoh, K (corresponding author), Oita Univ, Dept Endocrinol Metab Rheumatol & Nephrol, Fac Med, 1-1 Idaigaoka, Yufu City, Oita 8795593, Japan.
EM gotokoro@oita-u.ac.jp
RI Masaki, Takayuki/AAJ-6684-2020
OI Masaki, Takayuki/0000-0002-2378-849X
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NR 26
TC 28
Z9 39
U1 4
U2 16
PU JAPAN ENDOCRINE SOC
PI KYOTO
PA 75  YANAGINOBANBA NISHIIRU-MASUYA-CHO, SANJOU-DORI, NAKAGYOU-KU, KYOTO,
   604-8111, JAPAN
SN 0918-8959
EI 1348-4540
J9 ENDOCR J
JI Endocr. J.
PD APR
PY 2017
VL 64
IS 4
BP 375
EP 378
DI 10.1507/endocrj.EJ17-0060
PG 4
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA EV3UP
UT WOS:000401684900001
PM 28321033
OA gold
DA 2025-06-11
ER

PT J
AU Jadhav, PA
   Thomas, AB
   Chopada, VM
   Bokaria, PV
   Deokate, SB
   Chougule, PS
   Chavan, PN
   Chitlange, SS
AF Jadhav, Pranali A.
   Thomas, Asha B.
   Chopada, Vinay M.
   Bokaria, Prajay V.
   Deokate, Shivam B.
   Chougule, Pankaj S.
   Chavan, Pruthviraj N.
   Chitlange, Sohan S.
TI Correlation of non-alcoholic fatty liver disease and neurodegenerative
   disorders
SO EGYPTIAN LIVER JOURNAL
LA English
DT Review
DE NAFLD; Neurodegenerative disorders; Inflammation; Dyslipidaemia;
   Dysbiosis; Dementia
AB Non-alcoholic fatty liver disease and neurodegenerative disorders represent significant health challenges worldwide, with shared pathophysiological mechanisms. Evolving data indicates a bidirectional relationship between NAFLD and neurodegenerative disorders, with common risk factors, such as metabolic syndrome, inflammation, oxidative stress, and genetic predisposition, contributing to both conditions. Mechanistic links connecting NAFLD and neurodegeneration include systemic inflammation, dysregulation of the gut-liver-brain axis, and vascular dysfunction. This comprehensive review explores the intricate relationship between NAFLD and neurodegenerative disorders, focusing on shared pathophysiological mechanisms, common risk factors, and emerging therapeutic strategies. Furthermore, it presents evidence of the association between NAFLD and neurodegenerative disorders from clinical studies, underscoring the importance of understanding and addressing these interconnected conditions. A broad understanding of the complex linking between NAFLD and neurodegenerative disorders is essential for the advancement of future therapeutic strategies that can effectively lessen the load of these devastating conditions. By unveiling the shared pathophysiological mechanisms, common risk factors, and interconnected pathways linking NAFLD and neurodegeneration, researchers can identify novel therapeutic targets and interventions aimed at halting disease progression and preserving patient health.
C1 [Jadhav, Pranali A.; Thomas, Asha B.; Chitlange, Sohan S.] Dr DY Patil Inst Pharmaceut Sci & Res, Dept Pharmaceut Chem, Pune 411018, Maharashtra, India.
   [Chopada, Vinay M.; Bokaria, Prajay V.; Deokate, Shivam B.; Chougule, Pankaj S.; Chavan, Pruthviraj N.] Dr DY Patil Inst Pharmaceut Sci & Res, Dept Pharmaceut Sci, Pune 411018, Maharashtra, India.
RP Thomas, AB (corresponding author), Dr DY Patil Inst Pharmaceut Sci & Res, Dept Pharmaceut Chem, Pune 411018, Maharashtra, India.
EM asha.thomas@dypvp.edu.in
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NR 85
TC 0
Z9 0
U1 0
U2 0
PU SPRINGEROPEN
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, GWENT N1 9XW, ENGLAND
SN 2090-6218
EI 2090-6226
J9 EGYPT LIVER J
JI Egypt. Liver J.
PD NOV 4
PY 2024
VL 14
IS 1
AR 79
DI 10.1186/s43066-024-00386-9
PG 10
WC Gastroenterology & Hepatology
WE Emerging Sources Citation Index (ESCI)
SC Gastroenterology & Hepatology
GA L1M7X
UT WOS:001348440200001
OA gold
DA 2025-06-11
ER

PT J
AU Lin, QZ
   Zuo, WY
   Liu, YZ
   Wu, KK
   Liu, QM
AF Lin, Qiuzhen
   Zuo, Wanyun
   Liu, Yaozhong
   Wu, Keke
   Liu, Qiming
TI NAD<SUP>+</SUP> and cardiovascular diseases
SO CLINICA CHIMICA ACTA
LA English
DT Review
DE NAD(+); NADH; SIRTs; Biological processes; Cardiovascular disease
ID CARDIAC SODIUM-CHANNEL; ADENINE-DINUCLEOTIDE PHOSPHATE; GATED K+
   CHANNELS; NICOTINAMIDE RIBOSIDE; OXIDATIVE-METABOLISM; BRAIN-DAMAGE;
   CELL-DEATH; MITOCHONDRIAL; SIRT1; PROTECTS
AB Nicotinamide adenine dinucleotide (NAD) plays pivotal roles in controlling many biochemical processes. 'NAD' refers to the chemical backbone irrespective of charge, whereas 'NAD(+)' and 'NADH' refers to oxidized and reduced forms, respectively. NAD(+)/NADH ratio is essential for maintaining cellular reduction-oxidation (redox) homeostasis and for modulating energy metabolism. As a sensing or consuming enzyme of the poly (ADP-ribose) polymerase 1 (PARP1), the cyclic ADP-ribose (cADPR) synthases (CD38 and CD157), and sirtuin protein deacetylases (sirtuins, SIRTs), NAD(+) participates in several key processes in cardiovascular disease. For example, NAD(+) protects against metabolic syndrome, heart failure, ischemia-reperfusion (IR) injury, arrhythmia and hypertension. Accordingly, the subsequent loss of NAD(+) in aging or during stress results in altered metabolic status and potentially increased disease susceptibility. Therefore, it is essential to maintain NAD(+) or reduce loss in the heart. This review focuses on the involvement of NAD(+) in the pathogenesis of cardiovascular disease and explores the effects of NAD(+) boosting strategies in cardiovascular health.
C1 Cent South Univ, Xiangya Hosp 2, Dept Cardiovasc Med, Changsha, Peoples R China.
   Cent South Univ, Res Inst Blood Lipid & Atherosclerosis, Changsha, Peoples R China.
   Modern Cardiovasc Dis Clin Technol Res Ctr Hunan, Changsha, Peoples R China.
   Cardiovasc Dis Res Ctr Hunan Prov, Changsha 410011, Hunan, Peoples R China.
C3 Central South University; Central South University
RP Liu, QM (corresponding author), 139 Middle Renmin Rd, Changsha 410011, Hunan, Peoples R China.
EM qimingliu@csu.edu.cn
FU National Natural Science Foundation of China [81770337]; Fundamental
   Research Funds for the Central Universities of Central South University
   [2020zzts289]
FX This project was supported by National Natural Science Foundation of
   China [no.81770337] and the Fundamental Research Funds for the Central
   Universities of Central South University [no.2020zzts289].
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NR 103
TC 31
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U1 7
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PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
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J9 CLIN CHIM ACTA
JI Clin. Chim. Acta
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DI 10.1016/j.cca.2021.01.012
EA JAN 2021
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WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA QP5PR
UT WOS:000623889300016
PM 33485900
DA 2025-06-11
ER

PT J
AU Kim, JM
   Jang, HJ
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   Ryu, SH
   Suh, PG
AF Kim, Jung-Min
   Jang, Hyun-Jun
   Choi, Soo Youn
   Park, Soo-Ah
   Kim, Il Shin
   Yang, Yong Ryoul
   Lee, Yong Hwa
   Ryu, Sung Ho
   Suh, Pann-Ghill
TI DJ-1 contributes to adipogenesis and obesity-induced inflammation
SO SCIENTIFIC REPORTS
LA English
DT Article
ID DJ-1-DEFICIENT MICE; INSULIN-RESISTANCE; ANDROGEN RECEPTOR;
   ADIPOSE-TISSUE; FAT; CELL; DIFFERENTIATION; INTERLEUKIN-6; HOMEOSTASIS;
   METABOLISM
AB Adipose tissue functions as an endocrine organ, and the development of systemic inflammation in adipose tissue is closely associated with metabolic diseases, such as obesity and insulin resistance. Accordingly, the fine regulation of the inflammatory response caused by obesity has therapeutic potential for the treatment of metabolic syndrome. In this study, we analyzed the role of DJ-1 (PARK7) in adipogenesis and inflammation related to obesity in vitro and in vivo. Many intracellular functions of DJ-1, including oxidative stress regulation, are known. However, the possibility of DJ-1 involvement in metabolic disease is largely unknown. Our results suggest that DJ-1 deficiency results in reduced adipogenesis and the down-regulation of pro-inflammatory cytokines in vitro. Furthermore, DJ-1- deficient mice show a low- level inflammatory response in the high-fat diet-induced obesity model. These results indicate previously unknown functions of DJ-1 in metabolism and therefore suggest that precise regulation of DJ-1 in adipose tissue might have a therapeutic advantage for metabolic disease treatment.
C1 [Kim, Jung-Min; Jang, Hyun-Jun; Choi, Soo Youn; Park, Soo-Ah; Kim, Il Shin; Yang, Yong Ryoul; Lee, Yong Hwa; Suh, Pann-Ghill] Ulsan Natl Inst Sci & Technol, Sch Nanobiosci & Chem Engn, Ulsan, South Korea.
   [Jang, Hyun-Jun; Ryu, Sung Ho] Pohang Univ Sci & Technol, Div Mol & Life Sci, Pohang, South Korea.
C3 Ulsan National Institute of Science & Technology (UNIST); Pohang
   University of Science & Technology (POSTECH)
RP Suh, PG (corresponding author), Ulsan Natl Inst Sci & Technol, Sch Nanobiosci & Chem Engn, Ulsan, South Korea.
EM pgsuh@unist.ac.kr
RI Suh, Pann-Ghill/F-3610-2010; Lee, Sun-Ho/AAD-6712-2022; Kim,
   Jung-Min/JDW-1037-2023
OI Jang, Hyun-Jun/0000-0002-2261-0067; Kim, Jung-Min/0000-0002-9072-4293;
   Ryu, Sung Ho/0000-0003-0913-3048
FU National Research Foundation of Korea - Korean Government [2012-000891]
FX This work was supported by the National Research Foundation of Korea
   Grant funded by the Korean Government (2012-000891). The authors have no
   conflict of interest to declare.
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NR 43
TC 28
Z9 31
U1 0
U2 10
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD JUN 13
PY 2014
VL 4
AR 4805
DI 10.1038/srep04805
PG 8
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA AJ0KJ
UT WOS:000337339400001
PM 24925581
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Zhang, SL
   Jin, S
   Zhang, C
   Hu, SM
   Li, HJ
AF Zhang, Silu
   Jin, Shuo
   Zhang, Cui
   Hu, Shumin
   Li, Huajun
TI Beer-gut microbiome alliance: a discussion of beer-mediated
   immunomodulation via the gut microbiome
SO FRONTIERS IN NUTRITION
LA English
DT Review
DE beer; nutrition; gut microbiome; food immunomodulatory; mucosal barrier;
   antioxidant
ID MODERATE ALCOHOL-CONSUMPTION; DIET-INDUCED OBESITY;
   CARDIOVASCULAR-DISEASE; INSULIN-RESISTANCE; OXIDATIVE STRESS;
   IMMUNE-SYSTEM; POLYPHENOLS; WINE; INFLAMMATION; ASSOCIATION
AB As a long-established fermented beverage, beer is rich in many essential amino acids, vitamins, trace elements, and bioactive substances that are involved in the regulation of many human physiological functions. The polyphenols in the malt and hops of beer are also important active compounds that interact in both directions with the gut microbiome. This review summarizes the mechanisms by which polyphenols, fiber, and other beneficial components of beer are fermentatively broken down by the intestinal microbiome to initiate the mucosal immune barrier and thus participate in immune regulation. Beer degradation products have anti-inflammatory, anticoagulant, antioxidant, and glucolipid metabolism-modulating potential. We have categorized and summarized reported data on changes in disease indicators and in vivo gut microbiota abundance following alcoholic and non-alcoholic beer consumption. The positive effects of bioactive substances in beer in cancer prevention, reduction of cardiovascular events, and modulation of metabolic syndrome make it one of the candidates for microecological modulators.
C1 [Zhang, Silu; Jin, Shuo; Li, Huajun] Dalian Med Univ, Dept Microecol, Dalian, Peoples R China.
   [Zhang, Cui; Hu, Shumin] Tsingtao Brewery Co Ltd, State Key Lab Biol Fermentat Engn Beer, Qingdao, Peoples R China.
C3 Dalian Medical University
RP Li, HJ (corresponding author), Dalian Med Univ, Dept Microecol, Dalian, Peoples R China.
EM lhjcmu@hotmail.com
RI 李, 华军/ABG-6228-2022; Zhang, Silu/AAB-4875-2019
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NR 92
TC 3
Z9 3
U1 4
U2 33
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD JUL 25
PY 2023
VL 10
AR 1186927
DI 10.3389/fnut.2023.1186927
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA O3PC4
UT WOS:001042960300001
PM 37560062
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Tsai, JP
   Hsu, BG
AF Tsai, Jett-Pi
   Hsu, Bang-Gee
TI Arterial stiffness: A brief review
SO TZU CHI MEDICAL JOURNAL
LA English
DT Review
DE Arterial stiffness; Cardiovascular disease; Chronic kidney disease;
   Pulse wave velocity
ID CHRONIC KIDNEY-DISEASE; PULSE-WAVE VELOCITY; ALL-CAUSE MORTALITY;
   INTIMA-MEDIA THICKNESS; STAGE RENAL-DISEASE; AORTIC STIFFNESS;
   BLOOD-PRESSURE; METABOLIC SYNDROME; ENDOTHELIAL DYSFUNCTION;
   CARDIOVASCULAR EVENTS
AB Apart from the result of multiple diseases as well as aging, arterial stiffness (AS) predicts cardiovascular disease (CVD), especially in patients with chronic kidney disease (CKI)). Patients with CKD have high CVD prevalence, and an extraordinarily high risk for CVD might be related to nontraditional risk factors, including AS. The mechanism of AS development could be attributed to oxidative stress, inflammation, uremic milieu (e.g., uremic toxins), vascular calcification, and cumulative effects of traditional cardiovascular risk factors on arteries such as diabetes mellitus or hypertension. There were a variety of non-invasive techniques to measure AS. One of these techniques is carotid-femoral pulse wave velocity, which is the reference measurement of AS and is related to long-term CVD outcomes. AS progression has corresponding medical treatments with modest beneficial results. This review briefly discusses the risk factors, measurements, and treatments associated with AS.
C1 [Tsai, Jett-Pi; Hsu, Bang-Gee] Tzu Chi Univ, Sch Med, Hualien, Taiwan.
   [Tsai, Jett-Pi] Dalin Tzu Chi Hosp, Buddhist Tzu Chi Med Fdn, Dept Internal Med, Div Nephrol, Chiayi, Taiwan.
   [Hsu, Bang-Gee] Hualien Tzu Chi Hosp, Buddhist Tzu Chi Med Fdn, Div Nephrol, 707,Sect 3,Chung Yang Rd, Hualien, Taiwan.
C3 Tzu Chi University; Buddhist Tzu Chi General Hospital; Dalin Tzu Chi
   Hospital; Buddhist Tzu Chi General Hospital; Hualien Tzu Chi Hospital
RP Hsu, BG (corresponding author), Hualien Tzu Chi Hosp, Buddhist Tzu Chi Med Fdn, Div Nephrol, 707,Sect 3,Chung Yang Rd, Hualien, Taiwan.
EM geelily@tzuchi.com.tw
RI Hsu, Bang-Gee/AAV-5287-2020
FU Ministry of Science and Technology, Taiwan
   [MOST-106-2314-B-303-019-MY3]; Buddhist Tzu Chi Medical Foundation,
   Taiwan [TCMF-MP 107-01-01]
FX This study was supported by a grant from the Ministry of Science and
   Technology, Taiwan (MOST-106-2314-B-303-019-MY3), and Buddhist Tzu Chi
   Medical Foundation, Taiwan (TCMF-MP 107-01-01).
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NR 87
TC 32
Z9 33
U1 0
U2 0
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, Maharashtra, INDIA
SN 1016-3190
EI 2223-8956
J9 TZU CHI MED J
JI Tzu Chi Med. J.
PD APR-JUN
PY 2021
VL 33
IS 2
BP 115
EP 121
DI 10.4103/tcmj.tcmj_44_20
PG 7
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA RI1WO
UT WOS:000636701900003
PM 33912407
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Pintana, H
   Chattipakorn, N
   Chattipakorn, S
AF Pintana, Hiranya
   Chattipakorn, Nipon
   Chattipakorn, Siriporn
TI Testosterone deficiency, insulin-resistant obesity and cognitive
   function
SO METABOLIC BRAIN DISEASE
LA English
DT Review
DE Obesity; Insulin resistance; Testosterone deprivation; Neuroprotective
   effect; Cognitive function
ID HORMONE-BINDING GLOBULIN; ADULT MALE RATS; HIPPOCAMPAL SYNAPTIC
   PLASTICITY; PITUITARY-ADRENAL AXIS; DIET-INDUCED OBESITY; MIDDLE-AGED
   MEN; GROWTH-FACTOR-I; HIGH-FAT DIETS; ALZHEIMERS-DISEASE; METABOLIC
   SYNDROME
AB Testosterone is an androgenic steroid hormone, which plays an important role in the regulation of male reproduction and behaviors, as well as in the maintenance of insulin sensitivity. Several studies showed that testosterone exerted beneficial effects in brain function, including preventing neuronal cell death, balancing brain oxidative stress and antioxidant activity, improving synaptic plasticity and involving cognitive formation. Although previous studies showed that testosterone deficiency is positively correlated with cognitive impairment and insulin-resistant obesity, several studies demonstrated contradictory findings. Thus, this review comprehensively summarizes the current evidence from in vitro, in vivo and clinical studies of the relationship between testosterone deficiency and insulin-resistant obesity as well as the correlation between either insulin-resistant obesity or testosterone deficiency and cognitive impairment. Controversial reports and the mechanistic insights regarding the roles of testosterone in insulin-resistant obesity and cognitive function are also presented and discussed.
C1 [Pintana, Hiranya; Chattipakorn, Nipon; Chattipakorn, Siriporn] Chiang Mai Univ, Fac Med, Neurophysiol Unit, Cardiac Electrophysiol Res & Training Ctr, Chiang Mai 50000, Thailand.
   [Pintana, Hiranya; Chattipakorn, Nipon] Chiang Mai Univ, Dept Physiol, Fac Med, Chiang Mai 50000, Thailand.
   [Chattipakorn, Siriporn] Chiang Mai Univ, Fac Dent, Dept Oral Biol & Diagnost Sci, Chiang Mai 50200, Thailand.
C3 Chiang Mai University; Chiang Mai University; Chiang Mai University
RP Chattipakorn, S (corresponding author), Chiang Mai Univ, Fac Med, Neurophysiol Unit, Cardiac Electrophysiol Res & Training Ctr, Chiang Mai 50000, Thailand.
EM scchattipakorn@gmail.com
RI Chattipakorn, Nipon/AAJ-4049-2021
OI Chattipakorn, Nipon/0000-0003-3026-718X; Chattipakorn,
   Siriporn/0000-0003-1677-7052
FU Thailand Research Fund [TRF-BRG5780016]; Royal Golden Jubilee PhD
   program [PHD/0025/2555 HPSC]; National Research Council of Thailand;
   NSTDA Research Chair Grant from the National Science and Technology
   Development Agency; Chiang Mai University Excellent Center Award
FX This work was supported by grants from the Thailand Research Fund
   TRF-BRG5780016 (SC), the Royal Golden Jubilee PhD program (PHD/0025/2555
   HP&SC), National Research Council of Thailand (SC), a NSTDA Research
   Chair Grant from the National Science and Technology Development Agency
   (NC) and Chiang Mai University Excellent Center Award (NC).
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NR 181
TC 24
Z9 28
U1 0
U2 19
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0885-7490
EI 1573-7365
J9 METAB BRAIN DIS
JI Metab. Brain Dis.
PD AUG
PY 2015
VL 30
IS 4
BP 853
EP 876
DI 10.1007/s11011-015-9655-3
PG 24
WC Endocrinology & Metabolism; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology
GA CM1VT
UT WOS:000357469300002
PM 25703239
DA 2025-06-11
ER

PT J
AU Eguchi, K
   Manabe, I
   Oishi-Tanaka, Y
   Ohsugi, M
   Kono, N
   Ogata, F
   Yagi, N
   Ohto, U
   Kimoto, M
   Miyake, K
   Tobe, K
   Arai, H
   Kadowaki, T
   Nagai, R
AF Eguchi, Kosei
   Manabe, Ichiro
   Oishi-Tanaka, Yumiko
   Ohsugi, Mitsuru
   Kono, Nozomu
   Ogata, Fusa
   Yagi, Nobuhiro
   Ohto, Umeharu
   Kimoto, Masao
   Miyake, Kensuke
   Tobe, Kazuyuki
   Arai, Hiroyuki
   Kadowaki, Takashi
   Nagai, Ryozo
TI Saturated Fatty Acid and TLR Signaling Link β Cell Dysfunction and Islet
   Inflammation
SO CELL METABOLISM
LA English
DT Article
ID ENDOPLASMIC-RETICULUM STRESS; TYPE-2 DIABETES-MELLITUS; TOLL-LIKE
   RECEPTOR-4; INSULIN SENSITIVITY; METABOLIC SYNDROME; GLUCOSE-TOLERANCE;
   PANCREATIC-ISLETS; ADIPOSE-TISSUE; MACROPHAGES; PLASMA
AB Consumption of foods high in saturated fatty acids (FAs) as well as elevated levels of circulating free FAs are known to be associated with T2D. Though previous studies showed inflammation is crucially involved in the development of insulin resistance, how inflammation contributes to beta cell dysfunction has remained unclear. We report here the saturated FA palmitate induces beta cell dysfunction in vivo by activating inflammatory processes within islets. Through a combination of in vivo and in vitro studies, we show beta cells respond to palmitate via the TLR4/MyD88 pathway and produce chemokines that recruit CD11b(+)Ly-6C(+) M1-type proinflammatory monocytes/macrophages to the islets. Depletion of M1-type cells protected mice from palmitate-induced beta cell dysfunction. Islet inflammation also plays an essential role in beta cell dysfunction in T2D mouse models. Collectively, these results demonstrate a clear mechanistic link between beta cell dysfunction and inflammation mediated at least in part via the FFA-TLR4/MyD88 pathway.
C1 [Eguchi, Kosei; Manabe, Ichiro; Oishi-Tanaka, Yumiko; Ogata, Fusa; Nagai, Ryozo] Univ Tokyo, Grad Sch Med, Dept Cardiovasc Med, Bunkyo Ku, Tokyo 1138655, Japan.
   [Manabe, Ichiro; Kadowaki, Takashi; Nagai, Ryozo] Univ Tokyo, Grad Sch Med, Global Ctr Educ & Res Chem Biol Dis, Bunkyo Ku, Tokyo 1138655, Japan.
   [Oishi-Tanaka, Yumiko; Kadowaki, Takashi; Nagai, Ryozo] Univ Tokyo, Grad Sch Med, Translat Syst Biol & Med Initiat, Bunkyo Ku, Tokyo 1138655, Japan.
   [Ohsugi, Mitsuru; Kadowaki, Takashi] Univ Tokyo, Grad Sch Med, Dept Metab Dis, Bunkyo Ku, Tokyo 1138655, Japan.
   [Kono, Nozomu; Ohto, Umeharu; Arai, Hiroyuki] Univ Tokyo, Grad Sch Pharmaceut Sci, Bunkyo Ku, Tokyo 1130033, Japan.
   [Yagi, Nobuhiro] Kyowa Hakko Kirin Co Ltd, Med Chem Res Labs, Nagaizumi, Shizuoka 4118731, Japan.
   [Kimoto, Masao] Saga Univ, Fac Med, Dept Biomol Sci, Div Immunol, Saga 8498501, Japan.
   [Miyake, Kensuke] Univ Tokyo, Inst Med Sci, Div Infect Genet, Minato Ku, Tokyo 1088639, Japan.
   [Tobe, Kazuyuki] Toyama Univ, Fac Med, Dept Internal Med 1, Toyama 9300194, Japan.
   [Nagai, Ryozo] Tokyo Univ Hosp, Translat Res Ctr, Bunkyo Ku, Tokyo 1138655, Japan.
C3 University of Tokyo; University of Tokyo; University of Tokyo;
   University of Tokyo; University of Tokyo; Kyowa Kirin Ltd; Saga
   University; University of Tokyo; University of Toyama; University of
   Tokyo
RP Manabe, I (corresponding author), Univ Tokyo, Grad Sch Med, Dept Cardiovasc Med, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1138655, Japan.
EM manabe-tky@umin.ac.jp; nagai-tky@umin.ac.jp
RI Manabe, Ichiro/AAE-5105-2021; KONO, nozomu/AAM-3178-2020; Arai,
   Hiroyuki/HGU-8005-2022; Kadowaki, Takashi/JDM-5007-2023
FU JSPS; JST; MEXT, Japan; Japan Science and Technology Institute; Sumitomo
   Foundation; Takeda Science Foundation; SENSHIN medical research
   foundation; Mochida Memorial Foundation for Medical and Pharmaceutical
   Research; Grants-in-Aid for Scientific Research [23121510, 21117002,
   22117504, 22229006, 24117703, 23770106, 23227004, 22790691] Funding
   Source: KAKEN
FX We thank A. Ono, Y. Xiao, N. Yamanaka, Y. Tani, M. Takahashi, and M.
   Hayashi for their excellent technical assistance. We would like to thank
   Takashi Miki (Chiba University) and Satoshi limuro (University of Tokyo)
   for valuable discussion. This study was supported by "Funding Program
   for World-Leading Innovative R&D on Science and Technology (FIRST
   Program)" initiated by the Council for Science and Technology Policy
   (CSTP) from JSPS (to R.N.) and Grant-in-Aid for Scientific Research (S)
   and (B) from JSPS (to R.N. and I.M.); a grant for Translational Systems
   Biology and Medicine Initiative (to R.N.) from JST; Grant-in-Aid for
   Scientific Research on Innovative. Areas "Homeostatic Inflammation" (to
   I.M.) from MEXT, Japan; and research grants from the Japan Science and
   Technology Institute, Sumitomo Foundation, Takeda Science Foundation,
   SENSHIN medical research foundation, and Mochida Memorial Foundation for
   Medical and Pharmaceutical Research (to I.M.).
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NR 53
TC 424
Z9 470
U1 0
U2 41
PU CELL PRESS
PI CAMBRIDGE
PA 50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA
SN 1550-4131
EI 1932-7420
J9 CELL METAB
JI Cell Metab.
PD APR 4
PY 2012
VL 15
IS 4
BP 518
EP 533
DI 10.1016/j.cmet.2012.01.023
PG 16
WC Cell Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Endocrinology & Metabolism
GA 922CC
UT WOS:000302523400013
PM 22465073
OA Bronze
DA 2025-06-11
ER

PT J
AU A-Kader, HH
AF A-Kader, H. Hesham
TI Nonalcoholic fatty liver disease in children living in the obeseogenic
   society
SO WORLD JOURNAL OF PEDIATRICS
LA English
DT Review
DE fatty liver; nonalcoholic fatty liver disease; obesity; pediatric liver
   disease
ID VITAMIN-E TREATMENT; Y GASTRIC BYPASS; 3RD NATIONAL-HEALTH;
   INSULIN-RESISTANCE; URSODEOXYCHOLIC ACID; BIOCHEMICAL MARKERS;
   HEPATIC-FIBROSIS; MAGNETIC-RESONANCE; METABOLIC SYNDROME; OXIDATIVE
   STRESS
AB The problem of obesity in children has grown considerably in recent years in the United States as well as the rest of the world. This has resulted in a marked increase in the prevalence of nonalcoholic liver disease in the pediatric age group. Nonalcoholic fatty liver disease (NAFLD) is currently the most common hepatic disorder seen in pediatric hepatology practice.
   We have reviewed the most recent literature regarding the prevalence, pathogenesis as well as the most recent advances in the diagnostic and therapeutic modalities of NAFLD in children.
   NAFLD affects a substantial portion of the population including children.
   The rising incidence of NAFLD, nonalcoholic steatohepatitis (NASH) and cirrhosis emphasizes the need for effective treatment options. The lack of complete understanding of the pathogenesis of NAFLD still limits our ability to develop novel therapeutic modalities that can target the metabolic derangements implicated in the development of the disorder.
C1 Univ Arizona, Dept Pediat, Div Gastroenterol Hepatol & Nutr, Tucson, AZ 85724 USA.
C3 University of Arizona
RP A-Kader, HH (corresponding author), Univ Arizona, Dept Pediat, Div Gastroenterol Hepatol & Nutr, 1501 N Campbell Ave,POB 245073, Tucson, AZ 85724 USA.
EM Hassan@peds.arizona.edu
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NR 120
TC 23
Z9 25
U1 0
U2 9
PU ZHEJIANG UNIV SCH MEDICINE
PI HANGZHOU
PA CHILDRENS HOSPITAL, 57 ZHUGAN XIANG, HANGZHOU, 310003, PEOPLES R CHINA
SN 1708-8569
EI 1867-0687
J9 WORLD J PEDIATR
JI World Journal of Pediatrics
PD NOV
PY 2009
VL 5
IS 4
BP 245
EP 254
DI 10.1007/s12519-009-0048-8
PG 10
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA 520AK
UT WOS:000271811900001
PM 19911138
DA 2025-06-11
ER

PT J
AU Zhang, JN
   Tu, ML
   Liu, ZH
   Zhang, GD
AF Zhang, Jianan
   Tu, Maolin
   Liu, Zhenhua
   Zhang, Guodong
TI Soluble epoxide hydrolase as a therapeutic target for obesity-induced
   disorders: roles of gut barrier function involved
SO PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
LA English
DT Review
DE Soluble epoxide hydrolase; Obesity; Gut microbiota; Intestinal barrier
   function
ID HIGH-FAT-DIET; BODY-MASS INDEX; INTESTINAL BARRIER; METABOLIC
   ENDOTOXEMIA; EPOXYEICOSATRIENOIC ACIDS; INSULIN-RESISTANCE;
   COLORECTAL-CANCER; LIVER-DISEASE; INHIBITION; MICE
AB Emerging research supports that soluble epoxide hydrolase (sEH), an enzyme involved in eicosanoid metabolism, could be a promising target for obesity-associated disorders. The sEH enzyme is overexpressed in many tissues of obese animals. Genetic ablation or pharmacological inhibition of sEH attenuates the development of a wide range of obesity-induced disorders, including endoplasmic reticulum stress, metabolic syndrome, kidney diseases, insulin resistance, fatty liver, hepatic steatosis, inflammation, and endothelial dysfunction. Furthermore, our recent research showed that genetic ablation or inhibition of sEH attenuated obesity-induced intestinal barrier dysfunction and its resulted bacterial translocation, which is widely regarded to be a central mechanism for the pathogenesis of various obesity-induced disorders. Together, these results support that targeting sEH could be a promising strategy to reduce risks of obesity-induced disorders, at least in part through blocking obesity-induced leaky gut syndrome.
C1 [Zhang, Jianan; Tu, Maolin; Zhang, Guodong] Univ Massachusetts, Dept Food Sci, Amherst, MA 01003 USA.
   [Tu, Maolin] Dalian Polytech Univ, Natl Engn Res Ctr Seafood, Collaborat Innovat Ctr Seafood Deep Proc, Dept Food Sci & Technol, Dalian, Peoples R China.
   [Liu, Zhenhua] Univ Massachusetts, Sch Publ Hlth & Hlth Sci, Nutr & Canc Prevent Lab, Amherst, MA 01003 USA.
   [Liu, Zhenhua] Tufts Univ, Vitamins & Carcinogenesis Lab, Jean Mayer USDA Human Nutr Res Ctr Aging, Boston, MA 02111 USA.
   [Liu, Zhenhua; Zhang, Guodong] Univ Massachusetts, Mol & Cellular Biol Grad Program, Amherst, MA 01003 USA.
C3 University of Massachusetts System; University of Massachusetts Amherst;
   Dalian Polytechnic University; University of Massachusetts System;
   University of Massachusetts Amherst; United States Department of
   Agriculture (USDA); Tufts University; University of Massachusetts
   System; University of Massachusetts Amherst
RP Zhang, GD (corresponding author), Univ Massachusetts, Dept Food Sci, Amherst, MA 01003 USA.; Zhang, GD (corresponding author), Univ Massachusetts, Mol & Cellular Biol Grad Program, Amherst, MA 01003 USA.
EM guodongezhang@umass.edu
RI Tu, Maolin/LSJ-4008-2024; Zhang, Jianan/AAE-5344-2022
OI Zhang, Guodong/0000-0001-7780-5470; Zhang, Jianan/0000-0001-9801-2779
FU USDA NIFA [2020-67017-30844, 2019-67017-29248, 2016-67017-24423];
   USDA/Hatch [MAS00556]; NIH/NCI [R03CA237795, R03CA218520]
FX Our research is supported by funding support from USDA NIFA
   2020-67017-30844, 2019-67017-29248, and 2016-67017-24423, USDA/Hatch
   MAS00556, NIH/NCI R03CA237795 and R03CA218520 (to G. Zhang).
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NR 99
TC 9
Z9 10
U1 0
U2 20
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0952-3278
EI 1532-2823
J9 PROSTAG LEUKOTR ESS
JI Prostaglandins Leukot. Essent. Fatty Acids
PD NOV
PY 2020
VL 162
AR 102180
DI 10.1016/j.plefa.2020.102180
PG 7
WC Biochemistry & Molecular Biology; Cell Biology; Endocrinology &
   Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology; Endocrinology &
   Metabolism
GA OU6WU
UT WOS:000591667900003
PM 33038829
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Wang, SJ
   Chen, YS
   Li, XY
   Zhang, WH
   Liu, ZJ
   Wu, M
   Pan, QJ
   Liu, HF
AF Wang, Shujun
   Chen, Yanse
   Li, Xiaoyu
   Zhang, Weihuang
   Liu, Zejian
   Wu, Man
   Pan, Qingjun
   Liu, Huafeng
TI Emerging role of transcription factor EB in mitochondrial quality
   control
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Review
DE Transcription factor EB; Mitochondrial quality control; Mitophagy;
   Reactive oxygen species; Therapeutic measures
ID LYSOSOMAL BIOGENESIS; OXIDATIVE STRESS; PRO-SURVIVAL; CELL-DEATH; TFEB;
   AUTOPHAGY; ACTIVATION; MITOPHAGY; PARKIN; EXPRESSION
AB Mitochondria are energy producers that play a vital role in cell survival. Mitochondrial dysfunction is involved in many diseases, including metabolic syndrome, neurodegenerative disorders, cardiomyopathies, cancer, obesity, and diabetic kidney disease, and challenges still remain in terms of treatments for these diseases. Mitochondrial quality control (MQC), which is defined as the maintenance of the quantity, morphology, and function of mitochondria, plays a pivotal role in maintaining cellular metabolic homeostasis and cell survival. Recently, growing evidence suggests that the transcription factor EB (TFEB) plays a pivotal role in MQC. Here, we systemically investigate the potential role and mechanisms of TFEB in MQC, which include the activation of mitophagy, regulation of mitochondrial biogenesis, reactive oxygen species (ROS) clearance, and the balance of mitochondria fission-fusion cycle. Importantly, we further discuss the therapeutic measures and effects aimed at TFEB on mitochondrial dysfunction-related diseases. Taken together, targeting TFEB to regulate MQC may represent an appealing therapeutic strategy for mitochondrial dysfunction related-diseases.
C1 [Wang, Shujun; Chen, Yanse; Li, Xiaoyu; Zhang, Weihuang; Liu, Zejian; Wu, Man; Pan, Qingjun; Liu, Huafeng] Guangdong Med Univ, Inst Nephrol, Key Lab Prevent & Management Chron Kidney Dis Zha, Affiliated Hosp, Zhanjiang 524001, Guangdong, Peoples R China.
C3 Guangdong Medical University
RP Pan, QJ; Liu, HF (corresponding author), 57 South Peoples Ave, Zhanjiang 524001, Guangdong, Peoples R China.
EM pqj@gdmu.edu.cn; hf-liu@263.net
RI Li, Xiaoyu/JEF-0569-2023
FU National Natural Science Foundation of China [81670654, 81974095];
   Medical Science and Technology Research Fund Project of Guangdong
   Province, China [A2018473]; Chinese Medicine Research Project of Chinese
   Medicine Bureau of Guangdong Province, China [20202096]
FX The work was supported by the National Natural Science Foundation of
   China (grant number 81670654, 81974095), Medical Science and Technology
   Research Fund Project of Guangdong Province, China (grant number
   A2018473), Chinese Medicine Research Project of Chinese Medicine Bureau
   of Guangdong Province, China (grant number 20202096).
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NR 114
TC 45
Z9 47
U1 3
U2 16
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD AUG
PY 2020
VL 128
AR 110272
DI 10.1016/j.biopha.2020.110272
PG 10
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA NE9VN
UT WOS:000562952100002
PM 32447212
OA gold
DA 2025-06-11
ER

PT J
AU Eun, Y
   Han, KD
   Kim, DH
   Kim, IY
   Park, EJ
   Lee, S
   Cha, HS
   Koh, EM
   Lee, J
   Kim, H
AF Eun, Yeonghee
   Han, Kyung-Do
   Kim, Da Hye
   Kim, In Young
   Park, Eun-Jung
   Lee, Seulkee
   Cha, Hoon-Suk
   Koh, Eun-Mi
   Lee, Jaejoon
   Kim, Hyungjin
TI Association between anemia and hyperuricemia: results from the Korean
   National Health and Nutrition Examination Survey
SO SCIENTIFIC REPORTS
LA English
DT Article
ID CHRONIC KIDNEY-DISEASE; US GENERAL-POPULATION; URIC-ACID; OXIDATIVE
   STRESS; METABOLIC SYNDROME; RISK-FACTOR; PREVALENCE; INFLAMMATION;
   OBESITY; GOUT
AB Hyperuricemia and anemia share several comorbidities, but the association between the two conditions remains unclear. The purpose of this study was to investigate the association between hyperuricemia and anemia. Data of 10794 subjects from the Korean National Health and Nutrition Examination Survey conducted in 2016-2017 were analyzed using multivariate logistic regression analyses. An association between anemia and hyperuricemia was not evident in subjects without chronic kidney disease (CKD). In patients with CKD, anemia increased the risk of hyperuricemia by 2-fold. This association remained significant when adjusting for the glomerular filtration rate. In subgroup analyses, the association of anemia with hyperuricemia was significant in subjects aged >= 65 years, and in those with diabetes or hypertension. Subgroup analyses of CKD patients showed similar results. In the current study using data from Korean representative samples, anemia in subjects with CKD was associated with a 2-fold increase in the risk of hyperuricemia, which remained significant even after adjustment for renal function.
C1 [Eun, Yeonghee; Lee, Seulkee; Cha, Hoon-Suk; Koh, Eun-Mi; Lee, Jaejoon; Kim, Hyungjin] Sungkyunkwan Univ, Dept Med, Samsung Med Ctr, Sch Med, Seoul, South Korea.
   [Han, Kyung-Do; Kim, Da Hye] Catholic Univ Korea, Coll Med, Dept Biostat, Seoul, South Korea.
   [Kim, In Young] Natl Police Hosp, Dept Med, Seoul, South Korea.
   [Park, Eun-Jung] Natl Med Ctr, Dept Med, Seoul, South Korea.
C3 Sungkyunkwan University (SKKU); Samsung Medical Center; Catholic
   University of Korea; National Medical Center - Korea
RP Lee, J; Kim, H (corresponding author), Sungkyunkwan Univ, Dept Med, Samsung Med Ctr, Sch Med, Seoul, South Korea.
EM jaejoonlee.lee@samsung.com; passiondoc@gmail.com
RI Park, Eun/W-1340-2019; Han, Kyungdo/JKH-7628-2023; Kim,
   Hyungjin/JED-7172-2023
OI lee, seulkee/0000-0002-5551-4178
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NR 55
TC 14
Z9 14
U1 0
U2 3
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD DEC 13
PY 2019
VL 9
AR 19067
DI 10.1038/s41598-019-55514-y
PG 8
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA JW5DJ
UT WOS:000503071900001
PM 31836793
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Sottero, B
   Rossin, D
   Staurenghi, E
   Gamba, P
   Poli, G
   Testa, G
AF Sottero, Barbara
   Rossin, Daniela
   Staurenghi, Erica
   Gamba, Paola
   Poli, Giuseppe
   Testa, Gabriella
TI Omics analysis of oxysterols to better understand their
   pathophysiological role
SO FREE RADICAL BIOLOGY AND MEDICINE
LA English
DT Review
DE Oxysterols; Cholesterol; Lipidomics; Liquid- and
   gas-chromatography/mass-spectrometry; Cardiovascular diseases;
   Neurological diseases; Metabolic diseases; Cancer; Inflammation;
   Oxidative stress
ID CHROMATOGRAPHY-MASS SPECTROMETRY; CHOLESTEROL OXIDATION-PRODUCTS; HUMAN
   PLASMA; SIMULTANEOUS QUANTIFICATION; CEREBROSPINAL-FLUID; HEPATIC
   OXYSTEROLS; METABOLIC SYNDROME; DISEASE; BRAIN; PREECLAMPSIA
AB High amounts of cholesterol have been definitely associated with the pathogenesis of several diseases, including metabolic and neurodegenerative disorders, cardiovascular diseases, and cancer. In all these pathologies the exacerbation of pro-oxidant and inflammatory responses is a consistent feature. In this scenario, species derived from enzymatic and non-enzymatic cholesterol oxidation, namely oxysterols, are strongly suspected to play a primary role. The consideration of these bioactive lipids is therefore helpful in investigating pathological mechanisms and may also acquire clinical value for the diagnosis and treatment of diseases. For this purpose and considering that a great number of oxysterols may be present together in the body, the employment of lipidomics technology certainly represents a powerful strategy for the simultaneous detection and characterization of these compounds in biological specimens. In this review, we will discuss the applicability of the lipidomics approach in the study of the association between oxysterols and diseases.
C1 [Sottero, Barbara; Rossin, Daniela; Staurenghi, Erica; Gamba, Paola; Poli, Giuseppe; Testa, Gabriella] Univ Torino, San Luigi Hosp, Dept Clin & Biol Sci, Reg Gonzole 10, I-10043 Turin, Italy.
C3 University of Turin
RP Sottero, B (corresponding author), Univ Torino, San Luigi Hosp, Dept Clin & Biol Sci, Reg Gonzole 10, I-10043 Turin, Italy.
EM barbara.sottero@unito.it
RI Rossin, Daniela/AAD-4829-2022; Staurenghi, Erica/AAC-3383-2022; Gamba,
   Paola/AAA-6585-2019; Testa, Gabriella/IAQ-4907-2023
OI ROSSIN, DANIELA/0000-0001-5741-5774; Testa,
   Gabriella/0000-0002-2835-2804; STAURENGHI, ERICA/0000-0001-5035-7401
FU Compagnia di San Paolo [CSTO167048]; University of Torino [RILO2016,
   RILO2017]
FX The work was supported by the Compagnia di San Paolo (CSTO167048) and
   the University of Torino (RILO2016 and RILO2017).
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NR 102
TC 27
Z9 27
U1 1
U2 18
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0891-5849
EI 1873-4596
J9 FREE RADICAL BIO MED
JI Free Radic. Biol. Med.
PD NOV 20
PY 2019
VL 144
SI SI
BP 55
EP 71
DI 10.1016/j.freeradbiomed.2019.05.026
PG 17
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA JJ1TG
UT WOS:000493943700005
PM 31141713
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Katsiki, N
   Mikhailidis, DP
   Mantzoros, CS
AF Katsiki, Niki
   Mikhailidis, Dimitri P.
   Mantzoros, Christos S.
TI Non-alcoholic fatty liver disease and dyslipidemia: An update
SO METABOLISM-CLINICAL AND EXPERIMENTAL
LA English
DT Article
DE Non-alcoholic fatty liver disease; Dyslipidemia; Statins; Ezetimibe;
   Antidiabetic drugs
ID OBSTRUCTIVE SLEEP-APNEA; HIGH-DENSITY-LIPOPROTEIN;
   CORONARY-HEART-DISEASE; CARDIOVASCULAR RISK-ASSESSMENT;
   RENIN-ANGIOTENSIN SYSTEM; INTIMA-MEDIA THICKNESS; CHRONIC
   KIDNEY-DISEASE; ALL-CAUSE MORTALITY; METABOLIC SYNDROME; HEPATIC
   STEATOSIS
AB Non-alcoholic fatty liver (NAFLD) is the most common liver disease worldwide, progressing from simple steatosis to necroinflammation and fibrosis (leading to non-alcoholic steatohepatitis, NASH), and in some cases to cirrhosis and hepatocellular carcinoma. Inflammation, oxidative stress and insulin resistance are involved in NAFLD development and progression. NAFLD has been associated with several cardiovascular (CV) risk factors including obesity, dyslipidemia, hyperglycemia, hypertension and smoking. NAFLD is also characterized by atherogenic dyslipidemia, postprandial lipemia and high-density lipoprotein (HDL) dysfunction. Most importantly, NAFLD patients have an increased risk for both liver and CV disease (CVD) morbidity and mortality.
   In this narrative review, the associations between NAFLD, dyslipidemia and vascular disease in NAFLD patients are discussed. NAFLD treatment is also reviewed with a focus on lipid-lowering drugs. Finally, future perspectives in terms of both NAFLD diagnostic biomarkers and therapeutic targets are considered. (C) 2016 Elsevier Inc. All rights reserved.
C1 [Katsiki, Niki] Aristotle Univ Thessaloniki, Sch Med, Hippocrat Hosp, Propedeut Dept Internal Med 2, Thessaloniki, Greece.
   [Mikhailidis, Dimitri P.] UCL, Sch Med, Royal Free Hosp Campus, Dept Clin Biochem,Vasc Dis Prevent Clin, Pond St, London NW3 2QG, England.
   [Mantzoros, Christos S.] Harvard Med Sch, Div Endocrinol Diabet & Metab, Dept Internal Med, Beth Israel Deaconess Med Ctr, Boston, MA USA.
C3 Aristotle University of Thessaloniki; University of London; University
   College London; UCL Medical School; Royal Free London NHS Foundation
   Trust; Harvard University; Harvard Medical School; Harvard University
   Medical Affiliates; Beth Israel Deaconess Medical Center
RP Mikhailidis, DP (corresponding author), UCL, Sch Med, Royal Free Hosp Campus, Dept Clin Biochem,Vasc Dis Prevent Clin, Pond St, London NW3 2QG, England.
EM MIKHAILIDIS@aol.com
RI Mantzoros, Christos/Y-2902-2019; Mikhailidis, Dimitri/A-1869-2013;
   KATSIKI, NIKI/ADE-7999-2022
OI KATSIKI, NIKI/0000-0003-0894-2644
FU MSD; AstraZeneca; Novartis; Amgen; Sanofi; Novo Nordisk; Libytec
FX This publication was not sponsored. Niki Katsiki has given talks,
   attended conferences and participated in trials sponsored by MSD,
   AstraZeneca, Novartis, Amgen, Sanofi, Novo Nordisk and Libytec. Dimitri
   P Mikhailidis has given talks and attended conferences sponsored by MSD,
   AstraZeneca and Libytec. Christos S Mantzoros has no conflicts related
   to NAFLD/NASH or hyperlipidemia.
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NR 295
TC 449
Z9 471
U1 11
U2 284
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0026-0495
EI 1532-8600
J9 METABOLISM
JI Metab.-Clin. Exp.
PD AUG
PY 2016
VL 65
IS 8
BP 1109
EP 1123
DI 10.1016/j.metabol.2016.05.003
PG 15
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA DR4RH
UT WOS:000379889400010
PM 27237577
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Yan, JQ
   Zhao, Y
   Zhao, BL
AF Yan JingQi
   Zhao Yan
   Zhao BaoLu
TI Green tea catechins prevent obesity through modulation of peroxisome
   proliferator-activated receptors
SO SCIENCE CHINA-LIFE SCIENCES
LA English
DT Article
DE obesity; green tea catechins; peroxisome proliferator
   activated-receptors (PPARs); hyperlipidemia; metabolic syndrome
ID OXIDATIVE STRESS; BODY-FAT; LIPID-METABOLISM; GENE-EXPRESSION;
   PPAR-GAMMA; BLACK TEA; POLYPHENOLS; RATS; DIFFERENTIATION; THERMOGENESIS
AB Epidemiological evidence and experimental studies suggest that drinking green tea is associated with a lower risk of obesity and related diseases. However, the mechanisms of these effects are not clear. In the present study, we investigated the anti-obesity mechanisms of green tea catechins (GTCs) through modulation of peroxisome proliferator activated-receptor (PPAR) pathways in high-fat diet-induced obesity in rats. GTC supplementation significantly attenuated the increased body and liver weights and the elevated serum and liver triglyceride levels. Meanwhile, GTCs increased the PPAR gamma levels in subcutaneous white adipose tissue (SWAT) and decreased the PPAR gamma levels in visceral white adipose tissue (VWAT). In addition, GTC treatment up-regulated the levels of PPAR delta in SWAT, VWAT, and brown adipose tissue and increased the expression of genes involved in fatty acid oxidation in brown adipose tissue. Our results suggest that GTCs exert their anti-obesity mechanism in part by modulating PPAR signaling pathways.
C1 [Yan JingQi; Zhao BaoLu] Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing 100101, Peoples R China.
   [Zhao Yan] Harbin Inst Technol Weihai, Dept Food Sci & Technol, Weihai 264209, Peoples R China.
C3 Chinese Academy of Sciences; Institute of Biophysics, CAS; Harbin
   Institute of Technology
RP Zhao, BL (corresponding author), Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing 100101, Peoples R China.
EM zhaobl@sun5.ibp.ac.cn
OI yan, Jingqi/0000-0002-7024-6423
FU National Natural Science Foundation of China [30170239, 30930036]
FX We thank Ms. Xiang Shi for her excellent technical assistance and help
   with animal care and administration. This work was supported by the
   National Natural Science Foundation of China (30170239, 30930036).
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NR 35
TC 49
Z9 57
U1 2
U2 59
PU SCIENCE PRESS
PI BEIJING
PA 16 DONGHUANGCHENGGEN NORTH ST, BEIJING 100717, PEOPLES R CHINA
SN 1674-7305
EI 1869-1889
J9 SCI CHINA LIFE SCI
JI Sci. China-Life Sci.
PD SEP
PY 2013
VL 56
IS 9
BP 804
EP 810
DI 10.1007/s11427-013-4512-2
PG 7
WC Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics
GA 208HT
UT WOS:000323669300005
PM 23864528
OA hybrid
DA 2025-06-11
ER

PT J
AU Litwin, M
   Michalkiewicz, J
   Gackowska, L
AF Litwin, Mieczyslaw
   Michalkiewicz, Jacek
   Gackowska, Lidia
TI Primary Hypertension in Children and Adolescents is an Immuno-Metabolic
   Disease with Hemodynamic Consequences
SO CURRENT HYPERTENSION REPORTS
LA English
DT Article
DE Primary hypertension; PH; Children; Adolescents; Immune activity;
   Cytokines; T regulatory cells; Metabolic syndrome; Visceral obesity;
   Blood pressure; BP; Cardiovascular disease; CVD; Target organ damage;
   TOD; Treatment
ID RENIN-ANGIOTENSIN SYSTEM; LEFT-VENTRICULAR MASS; AMBULATORY
   BLOOD-PRESSURE; ALTERED GENE-EXPRESSION; II-INDUCED HYPERTENSION;
   SCHOOL-AGED CHILDREN; INSULIN-RESISTANCE; CARDIOVASCULAR RISK; OXIDATIVE
   STRESS; TISSUE INHIBITOR
AB With the rise in obesity epidemic primary hypertension (PH) is now one of the most common chronic diseases in adolescence. In contrast to hypertensive adults, hypertensive children usually are not exposed to other comorbidities such as diabetes, chronic kidney disease and atherosclerosis. Thus, PH in children and adolescents can be treated as the early stage of development of cardiovascular disease. There is increasing amount of data indicating that PH is not only hemodynamic phenomenon but a complex syndrome involving disturbed activity of sympathetic nervous system, metabolic abnormalities and activation of innate and adaptive immune system. We discuss results of the studies on clinical, metabolic and immunological phenotype of hypertensive children, associations between metabolic and immunological abnormalities with target organ damage and results of antihypertensive treatment.
C1 [Litwin, Mieczyslaw] Childrens Mem Hlth Inst, Dept Nephrol & Arterial Hypertens, Warsaw, Poland.
   [Michalkiewicz, Jacek] Childrens Mem Hlth Inst, Dept Microbiol & Immunol, Warsaw, Poland.
   [Michalkiewicz, Jacek; Gackowska, Lidia] Nicolaus Copernicus Univ, Coll Med, Chair Immunol, Torun, Poland.
C3 Children's Memorial Health Institute; Children's Memorial Health
   Institute; Nicolaus Copernicus University
RP Litwin, M (corresponding author), Childrens Mem Hlth Inst, Dept Nephrol & Arterial Hypertens, Warsaw, Poland.
EM m.litwin@czd.pl
RI Michałkiewicz, Jacek/I-1135-2014; Litwin, Mieczyslaw/L-4648-2017;
   Gackowska, Lidia/G-8885-2014
OI Litwin, Mieczyslaw/0000-0002-5241-2483; Michalkiewicz,
   Jacek/0000-0001-7773-1766; Gackowska, Lidia/0000-0001-7666-504X
FU Polish Scientific Committee [855/B/P01/2008/34, 4552/B/P01/2009/37,
   5412/B/P01/2010/39]; National Science Center [2011/01/B/NZ6/02661]
FX This study was supported by grants from the Polish Scientific Committee
   (855/B/P01/2008/34, 4552/B/P01/2009/37, 5412/B/P01/2010/39) and National
   Science Center (2011/01/B/NZ6/02661).
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NR 62
TC 22
Z9 26
U1 0
U2 17
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1522-6417
EI 1534-3111
J9 CURR HYPERTENS REP
JI Curr. Hypertens. Rep.
PD AUG
PY 2013
VL 15
IS 4
BP 331
EP 339
DI 10.1007/s11906-013-0360-5
PG 9
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 184BN
UT WOS:000321861400008
PM 23737217
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Widimsky, J
   Strauch, B
   Petrák, O
   Rosa, J
   Somloova, Z
   Zelinka, T
   Holaj, R
AF Widimsky, J., Jr.
   Strauch, B.
   Petrak, O.
   Rosa, J.
   Somloova, Z.
   Zelinka, T.
   Holaj, R.
TI Vascular Disturbances in Primary Aldosteronism: Clinical Evidence
SO KIDNEY & BLOOD PRESSURE RESEARCH
LA English
DT Review
DE Primary aldosteronism; Blood vessels; Abnormalities
ID INTIMA-MEDIA THICKNESS; PRIMARY HYPERALDOSTERONISM;
   ESSENTIAL-HYPERTENSION; METABOLIC SYNDROME; RESISTANT HYPERTENSION;
   ARTERIAL STIFFNESS; CAROTID-ARTERY; RENIN RATIO; PREVALENCE;
   ADRENALECTOMY
AB Primary aldosteronism (PA) is a common form of arterial hypertension with a high prevalence of cardiovascular complications. In patients with PA, complex mechanisms may lead to functional and/or structural abnormalities of the blood vessel wall. Clinical evidence indicates that patients with PA may have immune cell activation, increased oxidative stress, impaired endothelial function and vascular remodeling. Activation of fibroproliferation has been found in resistant arteries of patients with PA. Subjects with PA compared to essential hypertensives with similar blood pressure levels have increased intima-media thickness and arterial stiffness as measured by pulse wave velocity. These functional and morphological changes can be modified by an increased sodium intake. Vascular remodeling in PA may indicate a poor response to specific therapy with lower probability of cure and/or normalization of blood pressure. Early diagnosis of PA before blood vessel wall disturbances develop is of utmost importance. Copyright (C) 2012 S. Karger AG, Basel
C1 [Widimsky, J., Jr.; Strauch, B.; Petrak, O.; Rosa, J.; Somloova, Z.; Zelinka, T.; Holaj, R.] Charles Univ Prague, Ctr Hypertens, Dept Internal Med 3, Prague, Czech Republic.
C3 Charles University Prague
RP Widimsky, J (corresponding author), Gen Fac Hosp, Ctr Hypertens, Dept Internal Med 3, Nemocnice 1, CZ-12808 Prague, Czech Republic.
EM jwidi@lf1.cuni.cz
RI Kratka, Zuzana/Q-6488-2017; Rosa, Jan/M-1857-2017; Widimsky,
   Jiri/H-8647-2017; Petrak, Ondrej/A-5839-2017; Holaj, Robert/D-4241-2017;
   Zelinka, Tomas/D-4276-2017; Strauch, Branislav/D-4274-2017
OI Kratka, Zuzana/0000-0001-5107-2926; Rosa, Jan/0000-0001-7807-7751;
   Widimsky, Jiri/0000-0001-8242-9705; Petrak, Ondrej/0000-0001-8992-3562;
   Holaj, Robert/0000-0002-9488-9706; Zelinka, Tomas/0000-0003-3395-8373;
   Strauch, Branislav/0000-0001-5137-7017
FU Ministry of Education, Youth and Sports of the Czech Republic [MSM
   0021620807, MSM 0021620817];  [P35/LF1/5]
FX This study was supported with the following grants: MSM 0021620807 and
   MSM 0021620817 from the Ministry of Education, Youth and Sports of the
   Czech Republic and grant P35/LF1/5.
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NR 41
TC 24
Z9 24
U1 0
U2 4
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1420-4096
J9 KIDNEY BLOOD PRESS R
JI Kidney Blood Pressure Res.
PY 2012
VL 35
IS 6
BP 529
EP 533
DI 10.1159/000340031
PG 5
WC Physiology; Urology & Nephrology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology; Urology & Nephrology; Cardiovascular System & Cardiology
GA 083KB
UT WOS:000314461100018
PM 22890049
OA Bronze
DA 2025-06-11
ER

PT J
AU Chrigui, S
   Mbarek, S
   Taieb, SH
   Haouas, Z
   Feki, M
   Benlarbi, M
   Zemmel, A
   Chigr, F
   Boudhrioua, N
   Ben Chaouacha-Chekir, R
AF Chrigui, Souhaieb
   Mbarek, Sihem
   Taieb, Sameh Hadj
   Haouas, Zohra
   Feki, Monssef
   Benlarbi, Maha
   Zemmel, Ayachi
   Chigr, Fatiha
   Boudhrioua, Nourhene
   Ben Chaouacha-Chekir, Rafika
TI Behaviour of Tunisian Psammomys obesus fed high-calorie diets:
   biochemical disturbance and histopathological alterations
SO ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
LA English
DT Article
DE High calorie diet; Psammomys obesus; obesity; dyslipidemia; type 2
   diabetes; histological analysis
ID HIGH-FAT-DIET; METABOLIC SYNDROME; OXIDATIVE STRESS; ANIMAL-MODEL;
   OBESITY; PARAMETERS
AB This work investigated the biochemical disturbances and histological alteration in Psammomys obesus animal model fed different high calorie diets (HCDs) during three months. Four diets were used: a low-calorie natural diet, Chenopodiaceae halophyte plant used as control (LCD), a high standard carbohydrate diet rich in protein, HCD 0, a high carbohydrate diet rich in two concentrations of fat, HCD 1 and HCD 2. All animals having received HCDs developed dyslipidemia after one month of experiment with distinction of different sub-groups developing or not obesity and diabetes. HCDs induced a remarkable increasing in blood cholesterol, LDL-cholesterol and triglyceride levels indicating a fast induction of dyslipidemia and a significant increase of aminotransaminases activities revealing a pronounced hepatotoxicity. Animal developing diabetes showed a severe hepatic injury, a degeneration of the adipose tissue and a significant reduction of retinal thickness. P. obesus seems to be an excellent animal model to investigate nutritional metabolic diseases.
C1 [Chrigui, Souhaieb; Mbarek, Sihem; Benlarbi, Maha; Boudhrioua, Nourhene; Ben Chaouacha-Chekir, Rafika] Higher Inst Biotechnol Sidi Thabet, Lab Physiopathol Food & Biomol, LR17ES03, Ariana, Tunisia.
   [Taieb, Sameh Hadj; Feki, Monssef] Univ Tunis Manar, Rabta Hosp, Fac Med Tunis, Lab Clin Biochem, LR99ES11, Tunis, Tunisia.
   [Haouas, Zohra] Univ Monastir, Fac Med Monastir, Lab Histol & Cytogenet, LR18ES40, Monastir, Tunisia.
   [Zemmel, Ayachi] Herbes Tunisie, Siliana, Tunisia.
   [Chigr, Fatiha] Sultan Moulay Slimane Univ, Fac Sci & Tech, Biol Engn Lab, Beni Mellal, Morocco.
C3 Universite de la Manouba; Universite de Tunis-El-Manar; Hopital La
   Rabta; Faculte de Medecine de Tunis (FMT); Universite de Monastir;
   Sultan Moulay Slimane University of Beni Mellal
RP Boudhrioua, N; Ben Chaouacha-Chekir, R (corresponding author), Higher Inst Biotechnol Sidi Thabet, Lab Physiopathol Food & Biomol, Biotech Pole Sidi Thabet, LR17ES03, Ariana 2020, Tunisia.
EM nourhene.boudhrioua@isbst.uma.tn; rafika.chekir@isbst.uma.tn
RI ; Feki, Moncef/AAG-8543-2021
OI hadj taieb, sameh/0000-0002-6066-6758; Feki, Moncef/0000-0003-1585-4052;
   BOUDHRIOUA, Nourhene/0000-0001-9862-9744
FU Ministry of Higher Education and Scientific Research; Ministry of Higher
   Education and Scientific Research, National Research Promotion Agency
   (ANPR)
FX Authors are grateful to the Ministry of Higher Education and Scientific
   Research, National Research Promotion Agency (ANPR) for supporting PRIMA
   ARTISANEFOOD project and PAQ Collabora project: Ani-Biobank: Tunisian
   rodents used for testing biomolecules of economic interest, 2020-2024.
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NR 49
TC 1
Z9 1
U1 3
U2 3
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1381-3455
EI 1744-4160
J9 ARCH PHYSIOL BIOCHEM
JI Arch. Physiol. Biochem.
PD NOV 1
PY 2024
VL 130
IS 6
BP 934
EP 950
DI 10.1080/13813455.2024.2375983
EA JUL 2024
PG 17
WC Biochemistry & Molecular Biology; Biophysics; Endocrinology &
   Metabolism; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Endocrinology &
   Metabolism; Physiology
GA O5V8G
UT WOS:001269433000001
PM 38982878
DA 2025-06-11
ER

PT J
AU Lei, RB
   Chen, SY
   Li, WH
AF Lei, Ruobing
   Chen, Shuyi
   Li, Weihong
TI Advances in the study of the correlation between insulin resistance and
   infertility
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Review
DE insulin resistance; infertility; assisted reproductive technology;
   adverse pregnancy outcomes; offspring health
ID POLYCYSTIC-OVARY-SYNDROME; METABOLIC SYNDROME; WOMEN; PREVALENCE;
   MYOINOSITOL; RISK; HOMOCYSTEINE; ASSOCIATIONS; CRITERIA; PATHWAY
AB This is a narrative review of the progress of research on the correlation between insulin resistance and infertility. Insulin resistance (IR) is not only involved in the development of various metabolic diseases, but also affects female reproductive function, and to some extent is closely related to female infertility. IR may increase the risk of female infertility by activating oxidative stress, interfering with energy metabolism, affecting oocyte development, embryo quality and endometrial tolerance, affecting hormone secretion and embryo implantation, as well as affecting assisted conception outcomes in infertile populations and reducing the success rate of assisted reproductive technology treatment in infertile populations. In addition, IR is closely associated with spontaneous abortion, gestational diabetes and other adverse pregnancies, and if not corrected in time, may increase the risk of obesity and metabolic diseases in the offspring in the long term. This article provides a review of the relationship between IR and infertility to provide new ideas for the treatment of infertility.
C1 [Lei, Ruobing; Chen, Shuyi; Li, Weihong] Chongqing Med Univ, Affiliated Hosp 1, Reprod Med Ctr, Chongqing, Peoples R China.
C3 Chongqing Medical University
RP Li, WH (corresponding author), Chongqing Med Univ, Affiliated Hosp 1, Reprod Med Ctr, Chongqing, Peoples R China.
EM liweihong1211@163.com
FU National Natural Science Foundation of China [81501335]; General Program
   of Chongqing Natural Science Foundation [CSTB2022NSCQ-MSX0086]; Joint
   Program of the Chongqing Science and Technology Bureau; Chongqing Health
   Commission [2021MSXM141]
FX The author(s) declare financial support was received for the research,
   authorship, and/or publication of this article. This study was supported
   by grants from the National Natural Science Foundation of China (No.
   81501335), the General Program of Chongqing Natural Science Foundation
   (CSTB2022NSCQ-MSX0086) and the Joint Program of the Chongqing Science
   and Technology Bureau and the Chongqing Health Commission (No.
   2021MSXM141).
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NR 114
TC 13
Z9 13
U1 19
U2 28
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD JAN 26
PY 2024
VL 15
AR 1288326
DI 10.3389/fendo.2024.1288326
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA HN6C0
UT WOS:001160211500001
PM 38348417
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Nedyalkova, M
   Romanova, J
   Naneva, L
   Simeonov, V
AF Nedyalkova, Miroslava
   Romanova, Julia
   Naneva, Ludmila
   Simeonov, Vasil
TI Developing a questionnaire for diabetes mellitus type 2 risk effects and
   precondition factors - multivariate statistical paths
SO PHYSICAL SCIENCES REVIEWS
LA English
DT Article; Early Access
DE data treatment; diabetes mellitus type 2; multivariate statistics;
   questionnaire; survey
ID SELF-MANAGEMENT
AB The primary purpose of the present study is to summarize and explain the results of a questionnaire about diabetes mellitus type 2 (DMT2) endangered individuals. The 275 participants (age between 21 and 76 years) answered 18 questions related to the possible danger of DMT2 disorder. Multivariate statistical methods - cluster analysis, factor and principal components analysis applied for the survey analysis. The final goal was to detect similarity patterns between the variables of interest (questions), to reveal hidden factors regulating the data structure and susceptibility to DMT2 among the participants or between them, to elucidate the health status of the different groups and the similarities within the groups. It was found that five hidden factors regulate the data structure, which are conditionally named "declined general health status"; "metabolic syndrome factor"; "smoking, alcohol abuse and stress factor"; "heredity and sex impact"; "healthy food" impact. The participants could be divided into four similarity patterns, each with probably different susceptibility to DMT2. Thus, the results of the questionnaire could be of use for prophylactic purposes.
C1 [Nedyalkova, Miroslava] Univ Fribourg, Dept Chem, Chemin Musee 9, CH-1700 Fribourg, Switzerland.
   [Nedyalkova, Miroslava; Romanova, Julia; Naneva, Ludmila; Simeonov, Vasil] Univ Sofia St Kl Okhridski, Fac Chem & Pharm, J Bourchier Blvd 1, Sofia 1164, Bulgaria.
C3 University of Fribourg; University of Sofia
RP Nedyalkova, M (corresponding author), Univ Fribourg, Dept Chem, Chemin Musee 9, CH-1700 Fribourg, Switzerland.; Nedyalkova, M (corresponding author), Univ Sofia St Kl Okhridski, Fac Chem & Pharm, J Bourchier Blvd 1, Sofia 1164, Bulgaria.
EM miroslava.nedyalkova@unifr.ch; jromanova@chem.uni-sofia.bg;
   Ludmila.Naneva@mu-varna.bg; vsimeonov@chem.uni-sofia.bg
RI Nedyalkova, Miroslava/AAU-1615-2020; Naneva, lYUDMILA/IUN-8703-2023
OI Naneva, Lyudmila/0000-0001-8064-8525; Nedyalkova,
   Miroslava/0000-0003-0793-3340
FU Bulgarian National Science Fund [KP06/DzD R 03-14-2018]
FX This work was funded by Bulgarian National Science Fund (no. KP06/DzD R
   03-14-2018).
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NR 23
TC 1
Z9 1
U1 1
U2 3
PU WALTER DE GRUYTER GMBH
PI BERLIN
PA GENTHINER STRASSE 13, D-10785 BERLIN, GERMANY
SN 2365-6581
EI 2365-659X
J9 PHYS SCI REV
JI Phys. Sci. Rev.
PD 2022 APR 6
PY 2022
DI 10.1515/psr-2021-0158
EA APR 2022
PG 13
WC Multidisciplinary Sciences
WE Emerging Sources Citation Index (ESCI)
SC Science & Technology - Other Topics
GA 0G8WO
UT WOS:000778320400001
DA 2025-06-11
ER

PT J
AU Kuka, J
   Makrecka-Kuka, M
   Vilks, K
   Korzh, S
   Cirule, H
   Sevostjanovs, E
   Grinberga, S
   Dambrova, M
   Liepinsh, E
AF Kuka, Janis
   Makrecka-Kuka, Marina
   Vilks, Karlis
   Korzh, Stanislava
   Cirule, Helena
   Sevostjanovs, Eduards
   Grinberga, Solveiga
   Dambrova, Maija
   Liepinsh, Edgars
TI Inhibition of Fatty Acid Metabolism Increases EPA and DHA Levels and
   Protects against Myocardial Ischaemia-Reperfusion Injury in Zucker Rats
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Article
ID INSULIN SENSITIVITY; CONTENT DETERMINES; L-CARNITINE; FISH-OIL;
   OXIDATION; CARDIOPROTECTION; ACYLCARNITINES; RESISTANCE; ANIMALS; STRESS
AB Long-chain omega-3 polyunsaturated fatty acids (PUFAs) are known to induce cardiometabolic benefits, but the metabolic pathways of their biosynthesis ensuring sufficient bioavailability require further investigation. Here, we show that a pharmacological decrease in overall fatty acid utilization promotes an increase in the levels of PUFAs and attenuates cardiometabolic disturbances in a Zucker rat metabolic syndrome model. Metabolome analysis showed that inhibition of fatty acid utilization by methyl-GBB increased the concentration of PUFAs but not the total fatty acid levels in plasma. Insulin sensitivity was improved, and the plasma insulin concentration was decreased. Overall, pharmacological modulation of fatty acid handling preserved cardiac glucose and pyruvate oxidation, protected mitochondrial functionality by decreasing long-chain acylcarnitine levels, and decreased myocardial infarct size twofold. Our work shows that partial pharmacological inhibition of fatty acid oxidation is a novel approach to selectively increase the levels of PUFAs and modulate lipid handling to prevent cardiometabolic disturbances.
C1 [Kuka, Janis; Makrecka-Kuka, Marina; Vilks, Karlis; Korzh, Stanislava; Cirule, Helena; Sevostjanovs, Eduards; Grinberga, Solveiga; Dambrova, Maija; Liepinsh, Edgars] Latvian Inst Organ Synth, Lab Pharmaceut Pharmacol, Riga, Latvia.
   [Vilks, Karlis] Univ Latvia, Fac Biol, Riga, Latvia.
   [Dambrova, Maija] Riga Stradins Univ, Fac Pharm, Riga, Latvia.
C3 Latvian Institute of Organic Synthesis; University of Latvia; Riga
   Stradins University
RP Kuka, J (corresponding author), Latvian Inst Organ Synth, Lab Pharmaceut Pharmacol, Riga, Latvia.
RI Dambrova, Maija/V-6303-2019
OI Liepins, Edgars/0000-0003-2213-8337; Grinberga,
   Solveiga/0000-0002-7009-4220; Vilks, Karlis/0000-0002-4203-2129; Kuka,
   Janis/0000-0002-0411-0229; Dambrova, Maija/0000-0002-1739-0928
FU European Regional Development Fund [1.1.1.1/20/A/009]; European Union
   [857394]
FX The study was supported by the European Regional Development Fund
   project "Long-chain acylcarnitines in cardiovascular diseases: novel
   drug targets and diagnostic tools" (Nr. 1.1.1.1/20/A/009), and the
   authors were supported by the European Union's Horizon 2020 Research and
   Innovation Programme under grant agreement No. 857394. The methyl-GBB
   substance for this study was provided by JSC Grindeks.
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NR 51
TC 5
Z9 5
U1 1
U2 6
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PD JUL 29
PY 2021
VL 2021
AR 7493190
DI 10.1155/2021/7493190
PG 13
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA UA0HF
UT WOS:000684845900001
PM 34367467
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Pérez-Ramírez, IF
   de Diego, EH
   Riomoros-Arranz, M
   Reynoso-Camacho, R
   Saura-Calixto, F
   Pérez-Jiménez, J
AF Perez-Ramirez, Iza F.
   Hernandez de Diego, Elena
   Riomoros-Arranz, Marta
   Reynoso-Camacho, Rosalia
   Saura-Calixto, Fulgencio
   Perez-Jimenez, Jara
TI Effects of acute intake of grape/pomegranate pomace dietary supplement
   on glucose metabolism and oxidative stress in adults with abdominal
   obesity
SO INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION
LA English
DT Article
DE Grape; pomegranate; pomace; metabolic syndrome; abdominal obesity;
   polyphenols
ID NON-EXTRACTABLE POLYPHENOLS; TIME-OF-FLIGHT; ANTIOXIDANT ACTIVITY;
   PHENOLIC-COMPOUNDS; INSULIN-SECRETION; POMEGRANATE JUICE; FOOD;
   CINNAMON; FIBER; RISK
AB A controlled acute, cross-over clinical study (NCT02710461) was performed in order to evaluate the effects on glucose metabolism of a grape/pomegranate pomace dietary supplement in subjects with abdominal obesity (aged 40-60, n = 20). A standard 75 g oral glucose tolerance test (OGTT) was administered alone, together with or 10 h after the consumption of 10 g of the dietary supplement, rich in both extractable (0.4 g) and non-extractable (1.4 g) polyphenols. The dietary supplement did not ameliorate glucose or insulin at any sampling time. No improvement in antioxidant capacity was observed in plasma or urine, concordant with no increased urine polyphenol excretion. A tendency towards improved insulin sensitivity was observed when the product was consumed 10 h before glucose solution. These results suggest that a single realistic dose of grape/pomegranate pomace is not able to clearly improve glucose metabolism; chronic intake remains to be evaluated.
C1 [Perez-Ramirez, Iza F.; Reynoso-Camacho, Rosalia] Univ Autonoma Queretaro, Fac Quim, Res & Grad Studies Food Sci, Queretaro, Mexico.
   [Perez-Ramirez, Iza F.; Hernandez de Diego, Elena; Riomoros-Arranz, Marta; Saura-Calixto, Fulgencio; Perez-Jimenez, Jara] Inst Food Sci Technol & Nutr ICTAN CSIC, Dept Metab & Nutr, Jose Antonio Novais 10, Madrid 28040, Spain.
   [Hernandez de Diego, Elena] Univ Copenhagen, Dept Nutr Exercise & Sport, Copenhagen, Denmark.
C3 Universidad Autonoma de Queretaro; Consejo Superior de Investigaciones
   Cientificas (CSIC); CSIC - Instituto de Ciencia y Tecnologia de
   Alimentos y Nutricion (ICTAN); University of Copenhagen
RP Pérez-Jiménez, J (corresponding author), Inst Food Sci Technol & Nutr ICTAN CSIC, Dept Metab & Nutr, Jose Antonio Novais 10, Madrid 28040, Spain.
EM jara.perez@ictan.csic.es
RI Perez-Jimenez, Jara/B-3989-2009; Perez-Ramirez, Iza/G-9275-2019
OI Reynoso-Camacho, Rosalia/0000-0002-7223-0062; Perez-Ramirez,
   Iza/0000-0001-7606-0892
FU Spanish Ministry of Science and Innovation (MINECO-FEDER)
   [AGL2014-55102-JIN]; Consejo Nacional de Ciencia y Tecnologia (CONACyT)
FX This work was supported by the Spanish Ministry of Science and
   Innovation (MINECO-FEDER) under grant AGL2014-55102-JIN and by Consejo
   Nacional de Ciencia y Tecnologia (CONACyT) (international scholarship,
   I.F.P.-R.).
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NR 58
TC 19
Z9 20
U1 0
U2 37
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0963-7486
EI 1465-3478
J9 INT J FOOD SCI NUTR
JI Int. J. Food Sci. Nutr.
PD JAN 2
PY 2020
VL 71
IS 1
BP 94
EP 105
DI 10.1080/09637486.2019.1607831
EA MAY 2019
PG 12
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA JZ7KN
UT WOS:000471429600001
PM 31062633
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Lai, HM
   Liu, MSY
   Lin, TJ
   Tsai, YL
   Chien, EJ
AF Lai, Hung-Min
   Liu, Mark Shui-Yu
   Lin, Ting-Ju
   Tsai, Ying-Lan
   Chien, Eileen Jea
TI Higher DHEAS Levels Associated with Long-Term Practicing of Tai Chi
SO CHINESE JOURNAL OF PHYSIOLOGY
LA English
DT Article
DE aged; cortisol; exercise; meditation; quality of life; sex steroids
ID RANDOMIZED CONTROLLED-TRIAL; SALIVARY CORTISOL; RESISTANCE EXERCISE;
   METABOLIC SYNDROME; HORMONE RESPONSES; CANCER SURVIVORS; MEN; STRESS;
   ADULTS; ADAPTATIONS
AB Tai Chi has many benefits for middle-aged/older individuals including improvements to muscle strength and various body lipid components. DHEAS and testosterone have anti-obesity/anti-aging characteristics and also improve libido, vitality and immunity levels. Thus, the aim of the present study was to investigate the differences between middle-aged Tai Chi practitioners (n = 17) and sedentary individuals (n = 17) in terms of leg strength, blood levels of cholesterol, triglyceride, HDL, as well as DHEAS, testosterone and cortisol. Unpaired t-tests were used to identify significant differences between the two groups. There were no significant differences in body composition, leg strength, blood lipid components and testosterone. However, the Tai Chi practitioners had higher levels of DHEAS (P < 0.01) and lower levels of cortisol (P < 0.05). Thus, Tai Chi practitioners have a higher ratio of DHEAS to cortisol, which might have potential benefits in terms of improving an individual's health-related quality of life during the aging.
C1 [Liu, Mark Shui-Yu; Chien, Eileen Jea] Natl Yang Ming Univ, Inst Physiol, Sch Med, 155,Sec 2,Li Nong St, Taipei 11221, Taiwan.
   [Chien, Eileen Jea] China Med Univ, Grad Inst Biomed Sci, Coll Med, Taichung 40402, Taiwan.
   [Chien, Eileen Jea] Asia Univ, Dept Healthcare Adm, Taichung 41354, Taiwan.
   [Lai, Hung-Min; Lin, Ting-Ju; Tsai, Ying-Lan; Chien, Eileen Jea] Natl Taiwan Sports Univ, Grad Inst Athletic Training & Hlth, 250 Wenhua 1st Rd, Taoyuan 33301, Taiwan.
C3 National Yang Ming Chiao Tung University; China Medical University
   Taiwan; Asia University Taiwan; National Taiwan Sport University
RP Chien, EJ (corresponding author), Natl Yang Ming Univ, Inst Physiol, Sch Med, 155,Sec 2,Li Nong St, Taipei 11221, Taiwan.; Tsai, YL (corresponding author), Natl Taiwan Sports Univ, Grad Inst Athletic Training & Hlth, 250 Wenhua 1st Rd, Taoyuan 33301, Taiwan.
EM tsai@ntsu.edu.tw; eileen@ym.edu.tw
FU Ministry of Education, Aiming for the Top University Plan [104AC-P619];
   Cheng Hsin General Hospital, Taiwan, Republic of China [CY10524]
FX This research was supported by grants from Ministry of Education, Aiming
   for the Top University Plan (104AC-P619), and Cheng Hsin General
   Hospital (CY10524), Taiwan, Republic of China. We would also like to
   thank Dr. Ralph Kirby for his kind assistance during the preparation of
   the manuscript.
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NR 30
TC 8
Z9 9
U1 2
U2 19
PU CHINESE PHYSIOLOGICAL SOC
PI TAIPEI
PA CHINA MEDICAL UNIVERSITY HOSPITAL, UNIV MEDICAL CENTER OF AGING
   RESEARCH, TAIPEI, TAICHUNG 40402, TAIWAN
SN 0304-4920
J9 CHINESE J PHYSIOL
JI Chin. J. Physiol.
PD APR 30
PY 2017
VL 60
IS 2
BP 124
EP 130
DI 10.4077/CJP.2017.BAF454
PG 7
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Physiology
GA ET6RP
UT WOS:000400419800006
PM 28468030
DA 2025-06-11
ER

PT J
AU Marketou, M
   Gupta, Y
   Jain, S
   Vardas, P
AF Marketou, Maria
   Gupta, Yashaswi
   Jain, Shashank
   Vardas, Panos
TI Differential Metabolic Effects of Beta-Blockers: an Updated Systematic
   Review of Nebivolol
SO CURRENT HYPERTENSION REPORTS
LA English
DT Review
DE Hypertension; Insulin sensitivity; Lipid metabolism; Nebivolol; Obesity
ID TYPE-2 DIABETES-MELLITUS; INSULIN-RESISTANCE; BLOOD-PRESSURE;
   HYPERTENSIVE PATIENTS; NITRIC-OXIDE; ENDOTHELIAL DYSFUNCTION;
   CARDIOVASCULAR-DISEASE; ANTIHYPERTENSIVE DRUGS; ARTERIAL STIFFNESS;
   OXIDATIVE STRESS
AB Blood pressure management in hypertensive patients with metabolic abnormalities is challenging, since many of the antihypertensive drugs adversely affect metabolism. Besides effective control of blood pressure in patients with hypertension, third-generation beta-blockers such as nebivolol offer additional benefits for central hemodynamics and neutral or beneficial effects on metabolism. Emerging clinical data suggest that nebivolol also has similar effects on metabolism in obese hypertensive and hypertensive diabetic patients. The present article will provide a systematic analysis of the pathophysiological links among hypertension, insulin resistance, and metabolic syndrome. We will also summarize the available clinical evidence regarding the metabolic effects of betablockers in hypertensive patients, with an emphasis on nebivolol. Nebivolol exerts neutral or beneficial effects on insulin sensitivity and lipid metabolism in hypertensive patients, owing to its nitric oxide-mediated vasodilatory and antioxidative properties. Thus, nebivolol could be a favorable therapeutic option for the treatment of hypertension in patients with impaired glucose and lipid metabolism.
C1 [Marketou, Maria; Vardas, Panos] Heraklion Univ Hosp, Dept Cardiol, P O Box 1352, Iraklion, Greece.
   [Gupta, Yashaswi; Jain, Shashank] SPRIM Asia Pacif Pvt Ltd, Singapore, Singapore.
C3 University Hospital of Heraklion
RP Vardas, P (corresponding author), Heraklion Univ Hosp, Dept Cardiol, P O Box 1352, Iraklion, Greece.
EM cardio@med.uoc.gr
RI Marketou, Maria/AAW-1820-2021; vardas, panos/ABF-7144-2020
OI Marketou, Maria/0000-0003-1888-3430
FU A. Menarini
FX Editorial support for the preparation of this manuscript was provided by
   the SPRIM Company, Singapore, through an unrestricted educational grant
   by A. Menarini.
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NR 84
TC 30
Z9 32
U1 0
U2 6
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1522-6417
EI 1534-3111
J9 CURR HYPERTENS REP
JI Curr. Hypertens. Rep.
PD MAR
PY 2017
VL 19
IS 3
AR 22
DI 10.1007/s11906-017-0716-3
PG 10
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA EP4DW
UT WOS:000397331900005
PM 28283926
DA 2025-06-11
ER

PT J
AU Alegría-Torres, JA
   Velázquez-Villafaña, M
   López-Gutiérrez, JM
   Chagoyán-Martínez, MM
   Rocha-Amador, DO
   Costilla-Salazar, R
   García-Torres, L
AF Alejandro Alegria-Torres, Jorge
   Velazquez-Villafana, Marion
   Manuel Lopez-Gutierrez, Juan
   Chagoyan-Martinez, Marcela M.
   Rocha-Amador, Diana O.
   Costilla-Salazar, Rogelio
   Garcia-Torres, Lizeth
TI Association of Leukocyte Telomere Length and Mitochondrial DNA Copy
   Number in Children from Salamanca, Mexico
SO GENETIC TESTING AND MOLECULAR BIOMARKERS
LA English
DT Article
DE Mexican children; telomere length; mitochondrial DNA copy number
ID INSULIN-RESISTANCE; METABOLIC SYNDROME; OXIDATIVE STRESS; CANCER RISK;
   PARTICULATE MATTER; EXPOSURE; OBESITY; HEALTH; DAMAGE; HYDROCARBONS
AB Aim: The purpose of this study was to determine if there is a correlation between telomere length (TL) and mitochondrial DNA copy number (mtDNAcn) in children. Methods: Leukocyte TL and mtDNAcn were measured by real-time PCR in 98 Mexican children 6-12 years of age from Salamanca, Mexico. Results: A positive association was found between TL and mtDNAcn after a natural log transformation (Pearson correlation r = 0.72; p < 0.0001). No correlation between age and body mass index (BMI) biomarkers was found, and no differences according to sex were observed. After adjustment for these variables, a linear regression model showed an association between TL and mtDNAcn (beta = 0.739, 95% confidence interval 0.594; 0.885, p < 0.0001). Conclusions: A strong positive correlation between TL and mtDNAcn was found in the study population; age, sex, and BMI seemed to have no effect on this correlation.
C1 [Alejandro Alegria-Torres, Jorge; Velazquez-Villafana, Marion; Rocha-Amador, Diana O.] Univ Guanajuato, Dept Farm, Div Ciencias Nat & Exactas, Campus Guanajuato,Noria Alta S-N, Guanajuato 36050, Mexico.
   [Alejandro Alegria-Torres, Jorge; Garcia-Torres, Lizeth] Univ Centro Mexico UCEM, LIMON, Lab Invest Mol Nutr, San Luis Potosi, Mexico.
   [Manuel Lopez-Gutierrez, Juan; Costilla-Salazar, Rogelio] Univ Guanajuato, Dept Ciencias Ambientales, Div Ciencias Vida, Guanajuato, Mexico.
   [Chagoyan-Martinez, Marcela M.] Inst Politecn Nacl, Unidad Interdisciplinaria Ingn, Campus Guanajuato, Guanajuato, Mexico.
C3 Universidad de Guanajuato; Universidad de Guanajuato; Instituto
   Politecnico Nacional - Mexico
RP Alegría-Torres, JA (corresponding author), Univ Guanajuato, Dept Farm, Div Ciencias Nat & Exactas, Campus Guanajuato,Noria Alta S-N, Guanajuato 36050, Mexico.
EM ja.alegriatorres@ugto.mx
FU Mexican institution: CONCYTEG; Mexican institution: PRODEP; Mexican
   institution: CONACYT [269709]
FX This work was funded by the following Mexican institutions: CONCYTEG,
   PRODEP, and CONACYT (project 269709).
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NR 52
TC 11
Z9 11
U1 0
U2 9
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1945-0265
EI 1945-0257
J9 GENET TEST MOL BIOMA
JI Genet. Test. Mol. Biomark.
PD NOV
PY 2016
VL 20
IS 11
BP 654
EP 659
DI 10.1089/gtmb.2016.0176
PG 6
WC Biochemistry & Molecular Biology; Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Genetics & Heredity
GA EC4KI
UT WOS:000388097500003
PM 27622310
DA 2025-06-11
ER

PT J
AU Ma, XR
   Xu, LY
   Alberobello, AT
   Gavrilova, O
   Bagattin, A
   Skarulis, M
   Liu, J
   Finkel, T
   Mueller, E
AF Ma, Xinran
   Xu, Lingyan
   Alberobello, Anna Teresa
   Gavrilova, Oksana
   Bagattin, Alessia
   Skarulis, Monica
   Liu, Jie
   Finkel, Toren
   Mueller, Elisabetta
TI Celastrol Protects against Obesity and Metabolic Dysfunction through
   Activation of a HSF1-PGC1α Transcriptional Axis
SO CELL METABOLISM
LA English
DT Article
ID BROWN ADIPOSE-TISSUE; TRANSGENIC MOUSE MODEL; DIET-INDUCED OBESITY;
   HEAT-SHOCK RESPONSE; MOLECULAR CHAPERONES; ENERGY-EXPENDITURE; BEIGE
   ADIPOCYTES; SKELETAL-MUSCLE; STRESS-RESPONSE; GOD VINE
AB Altering the balance between energy intake and expenditure is a potential strategy for treating obesity and metabolic syndrome. Nonetheless, despite years of progress in identifying diverse molecular targets, biological-based therapies are limited. Here we demonstrate that heat shock factor 1 (HSF1) regulates energy expenditure through activation of a PGC1 alpha-dependent metabolic program in adipose tissues and muscle. Genetic modulation of HSF1 levels altered white fat remodeling and thermogenesis, and pharmacological activation of HSF1 via celastrol was associated with enhanced energy expenditure, increased mitochondrial function in fat and muscle and protection against obesity, insulin resistance, and hepatic steatosis during high-fat diet regimens. The beneficial metabolic changes elicited by celastrol were abrogated in HSF1 knockout mice. Overall, our findings identify the temperature sensor HSF1 as a regulator of energy metabolism and demonstrate that augmenting HSF1 via celastrol represents a possible therapeutic strategy to treat obesity and its myriad metabolic consequences.
C1 [Ma, Xinran; Xu, Lingyan; Alberobello, Anna Teresa; Bagattin, Alessia; Mueller, Elisabetta] NIDDK, Genet Dev & Dis Branch, NIH, Bethesda, MD 20892 USA.
   [Gavrilova, Oksana] NIDDK, Mouse Metab Core, NIH, Bethesda, MD 20892 USA.
   [Skarulis, Monica] NIDDK, Clin Endocrine Sect, NIH, Bethesda, MD 20892 USA.
   [Liu, Jie; Finkel, Toren] NHLBI, Ctr Mol Med, NIH, Bethesda, MD 20892 USA.
C3 National Institutes of Health (NIH) - USA; NIH National Institute of
   Diabetes & Digestive & Kidney Diseases (NIDDK); National Institutes of
   Health (NIH) - USA; NIH National Institute of Diabetes & Digestive &
   Kidney Diseases (NIDDK); National Institutes of Health (NIH) - USA; NIH
   National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK);
   National Institutes of Health (NIH) - USA; NIH National Heart Lung &
   Blood Institute (NHLBI)
RP Mueller, E (corresponding author), NIDDK, Genet Dev & Dis Branch, NIH, Bethesda, MD 20892 USA.
EM elisabettam@niddk.nih.gov
RI Xu, Lingyan/NIU-3150-2025
OI Bagattin, Alessia/0000-0002-8781-8301
FU NIDDK Intramural Research Program of the NIH
FX We are thankful to Richard Proia and Marc Reitman for reading the
   manuscript; to Pasha Sarraf for discussions throughout the project; and
   to Tatyana Chanturiya, Rachel Perron, and Ulrich Baxa for technical
   assistance. We also thank Jeffrey Kopp, Hidefumi Wakashin, and Shashi
   Shivrastav for kindly sharing their Seahorse Instrument; and Danielle
   Springer, Michele Allen, and Audrey Noguchi from the NHLBI murine core
   facility for technical support in metabolic phenotyping. This research
   was supported by funds of the NIDDK Intramural Research Program of the
   NIH.
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NR 52
TC 264
Z9 296
U1 3
U2 67
PU CELL PRESS
PI CAMBRIDGE
PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA
SN 1550-4131
EI 1932-7420
J9 CELL METAB
JI Cell Metab.
PD OCT 6
PY 2015
VL 22
IS 4
BP 695
EP 708
DI 10.1016/j.cmet.2015.08.005
PG 14
WC Cell Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Endocrinology & Metabolism
GA CW7PW
UT WOS:000365192600018
PM 26344102
OA Bronze
DA 2025-06-11
ER

PT J
AU Ryter, SW
   Koo, JK
   Choi, AMK
AF Ryter, Stefan W.
   Koo, Ja Kun
   Choi, Augustine M. K.
TI Molecular regulation of autophagy and its implications for metabolic
   diseases
SO CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE
LA English
DT Review
DE autophagy; diabetes; metabolic disease; metabolism; mitophagy; myopathy;
   obesity
ID ENDOPLASMIC-RETICULUM STRESS; CARDIAC AUTOPHAGY; THERAPEUTIC TARGET;
   PAGETS-DISEASE; POMPE DISEASE; MUSCLE; PROTEINS; COMPLEX; ENERGY;
   PATHOGENESIS
AB Purpose of review
   Autophagy is an evolutionarily conserved cellular programme for the turnover of organelles, proteins, and other macromolecules, involving the lysosomal degradation pathway. Emerging evidence suggests that autophagy can play a central role in human metabolism as well as impact diverse cellular processes including organelle homeostasis, cell death and proliferation, lipid and glycogen metabolism, and the regulation of inflammation and immune responses. The purpose of this review is to examine recent evidence for the role of autophagy in cellular metabolism, and its relevance to select human diseases that involve disorders of metabolism.
   Recent findings
   Recent studies suggest that autophagy may play multiple roles in metabolic diseases, including diabetes and its complications, metabolic syndrome and obesity, myopathies and other inborn errors of metabolism, as well as other diseases that may involve altered mitochondrial function.
   Summary
   Strategies aimed at modulating autophagy may lead to therapies for diseases in which altered cellular and tissue metabolism play a key role.
C1 [Ryter, Stefan W.; Koo, Ja Kun; Choi, Augustine M. K.] Weill Cornell Med Coll, Joan & Sanford I Weill Dept Med, New York, NY 10065 USA.
C3 Cornell University; Weill Cornell Medicine
RP Ryter, SW (corresponding author), Weill Cornell Med Coll, 525 East 68th St,Room M-522,Box 130, New York, NY 10065 USA.
EM str2020@med.cornell.edu
FU NIH [P01 HL108801, RO1 HL060234, R01 HL079904]
FX This work was supported by NIH grants P01 HL108801, RO1 HL060234 and R01
   HL079904.
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NR 88
TC 49
Z9 54
U1 0
U2 30
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1363-1950
EI 1473-6519
J9 CURR OPIN CLIN NUTR
JI Curr. Opin. Clin. Nutr. Metab. Care
PD JUL
PY 2014
VL 17
IS 4
BP 329
EP 337
DI 10.1097/MCO.0000000000000068
PG 9
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA AI9TV
UT WOS:000337282500006
PM 24848530
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Muoio, DM
   Noland, RC
   Kovalik, JP
   Seiler, SE
   Davies, MN
   DeBalsi, KL
   Ilkayeva, OR
   Stevens, RD
   Kheterpal, I
   Zhang, JY
   Covington, JD
   Bajpeyi, S
   Ravussin, E
   Kraus, W
   Koves, TR
   Mynatt, RL
AF Muoio, Deborah M.
   Noland, Robert C.
   Kovalik, Jean-Paul
   Seiler, Sarah E.
   Davies, Michael N.
   DeBalsi, Karen L.
   Ilkayeva, Olga R.
   Stevens, Robert D.
   Kheterpal, Indu
   Zhang, Jingying
   Covington, Jeffrey D.
   Bajpeyi, Sudip
   Ravussin, Eric
   Kraus, William
   Koves, Timothy R.
   Mynatt, Randall L.
TI Muscle-Specific Deletion of Carnitine Acetyltransferase Compromises
   Glucose Tolerance and Metabolic Flexibility
SO CELL METABOLISM
LA English
DT Article
ID HUMAN SKELETAL-MUSCLE; ACETYL-L-CARNITINE; PYRUVATE-DEHYDROGENASE
   COMPLEX; TYPE-2 DIABETIC-PATIENTS; INSULIN-RESISTANCE; MALONYL-COA;
   AS160 PHOSPHORYLATION; OBESE; OXIDATION; DISPOSAL
AB The concept of "metabolic inflexibility" was first introduced to describe the failure of insulin-resistant human subjects to appropriately adjust mitochondrial fuel selection in response to nutritional cues. This phenomenon has since gained increasing recognition as a core component of the metabolic syndrome, but the underlying mechanisms have remained elusive. Here, we identify an essential role for the mitochondrial matrix enzyme, carnitine acetyltransferase (CrAT), in regulating substrate switching and glucose tolerance. By converting acetyl-CoA to its membrane permeant acetylcarnitine ester, CrAT regulates mitochondrial and intracellular carbon trafficking. Studies in muscle-specific Crat knockout mice, primary human skeletal myocytes, and human subjects undergoing L-carnitine supplementation support a model wherein CrAT combats nutrient stress, promotes metabolic flexibility, and enhances insulin action by permitting mitochondrial efflux of excess acetyl moieties that otherwise inhibit key regulatory enzymes such as pyruvate dehydrogenase. These findings offer therapeutically relevant insights into the molecular basis of metabolic inflexibility.
C1 [Muoio, Deborah M.; Noland, Robert C.; Kovalik, Jean-Paul; Seiler, Sarah E.; Davies, Michael N.; DeBalsi, Karen L.; Ilkayeva, Olga R.; Stevens, Robert D.; Kraus, William; Koves, Timothy R.] Duke Univ, Dept Med, Sarah W Stedman Nutr & Metab Ctr, Durham, NC 27704 USA.
   [Muoio, Deborah M.; Noland, Robert C.; Kovalik, Jean-Paul; Seiler, Sarah E.; Davies, Michael N.; DeBalsi, Karen L.; Ilkayeva, Olga R.; Stevens, Robert D.; Kraus, William; Koves, Timothy R.] Duke Univ, Dept Pharmacol & Canc Biol, Sarah W Stedman Nutr & Metab Ctr, Durham, NC 27704 USA.
   [Kheterpal, Indu; Zhang, Jingying; Covington, Jeffrey D.; Bajpeyi, Sudip; Ravussin, Eric; Mynatt, Randall L.] Pennington Biomed Res Ctr, Baton Rouge, LA 70808 USA.
C3 Duke University; Duke University; Louisiana State University System;
   Louisiana State University; Pennington Biomedical Research Center
RP Muoio, DM (corresponding author), Duke Univ, Dept Med, Sarah W Stedman Nutr & Metab Ctr, Durham, NC 27704 USA.
EM muoio@duke.edu; randall.mynatt@pbrc.edu
RI Mynatt, Randall/N-1980-2017; Kraus, William/J-1411-2012; zhang,
   jingying/R-4262-2018; Koves, Tim/I-4806-2012; Noland,
   Robert/N-1982-2017; Muoio, Debbie/E-1147-2012; Ravussin,
   Eric/N-1985-2017
OI Bajpeyi, Sudip/0000-0002-5336-8330; Muoio, Deborah/0000-0003-3760-9277;
   Noland, Robert/0000-0001-5543-3450; Kraus, William
   E/0000-0003-1930-9684; Koves, Timothy/0000-0001-8763-5866; Ravussin,
   Eric/0000-0003-2129-547X
FU NIDDK [1F32DK080609, 1R01DK089312, 1R01AG028930]; American Diabetes
   Association; Claude Pepper Older Americans Center [AG028716]; NORC
   Center [1P30 DK072476]
FX This work was supported by funding from the NIDDK; 1F32DK080609 (R.N.),
   1R01DK089312 (D.M.M.), 1R01AG028930 (D.M.M. and W.E.K.), and the
   American Diabetes Association (D.M.M. and R.L.M.), a Claude Pepper Older
   Americans Center grant AG028716 (D.M.M. and T.R.K.), and by a NORC
   Center Grant # 1P30 DK072476 (R.L.M. and E.R.). We thank the dedicated
   staff of the Sarah W. Stedman Center Metabolomics and Biomarkers Core
   Facility; as well as Fausto Hegardt for providing the CrAT antibody. We
   also thank Dorothy Slentz, Steven Bond, Dieyun Ding, and Estrellita
   Bermudez for technical assistance.
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NR 46
TC 290
Z9 321
U1 0
U2 42
PU CELL PRESS
PI CAMBRIDGE
PA 50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA
SN 1550-4131
EI 1932-7420
J9 CELL METAB
JI Cell Metab.
PD MAY 2
PY 2012
VL 15
IS 5
BP 764
EP 777
DI 10.1016/j.cmet.2012.04.005
PG 14
WC Cell Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Endocrinology & Metabolism
GA 937WL
UT WOS:000303694100023
PM 22560225
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Perler, BK
   Friedman, ES
   Wu, GD
AF Perler, Bryce K.
   Friedman, Elliot S.
   Wu, Gary D.
TI The Role of the Gut Microbiota in the Relationship Between Diet and
   Human Health
SO ANNUAL REVIEW OF PHYSIOLOGY
LA English
DT Review
ID TRIMETHYLAMINE-N-OXIDE; INULIN-TYPE FRUCTANS; MEDITERRANEAN DIET;
   CARDIOVASCULAR-DISEASE; CALORIE RESTRICTION; INTESTINAL MICROBIOTA;
   METABOLIC DISEASE; CARBOHYDRATE-DIET; OXIDATIVE STRESS; RANDOMIZED-TRIAL
AB The interplay between diet, the gut microbiome, and host health is complex. Diets associated with health have many similarities: high fiber, unsaturated fatty acids, and polyphenols while being low in saturated fats, sodium, and refined carbohydrates. Over the past several decades, dietary patterns have changed significantly in Westernized nations with the increased consumption of calorically dense ultraprocessed foods low in fiber and high in saturated fats, salt, and refined carbohydrates, leading to numerous negative health consequences including obesity, metabolic syndrome, and cardiovascular disease. The gut microbiota is an environmental factor that interacts with diet and may also have an impact on health outcomes, many of which involve metabolites produced by the microbiota from dietary components that can impact the host. This review focuses on our current understanding of the complex relationship between diet, the gut microbiota, and host health, with examples of how diet can support health, increase an individual's risk for disease, and be used as a therapy for specific diseases.
C1 [Perler, Bryce K.; Friedman, Elliot S.; Wu, Gary D.] Univ Penn, Div Gastroenterol & Eleiratol, Perelman Sch Med, Philadelphia, PA 19104 USA.
C3 University of Pennsylvania
RP Wu, GD (corresponding author), Univ Penn, Div Gastroenterol & Eleiratol, Perelman Sch Med, Philadelphia, PA 19104 USA.
EM gdwu@pennmedicine.upenn.edu
RI Friedman, Elliot/A-9999-2018
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NR 147
TC 146
Z9 151
U1 58
U2 189
PU ANNUAL REVIEWS
PI PALO ALTO
PA 4139 EL CAMINO WAY, PO BOX 10139, PALO ALTO, CA 94303-0139 USA
SN 0066-4278
EI 1545-1585
J9 ANNU REV PHYSIOL
JI Annu. Rev. Physiol.
PY 2023
VL 85
BP 449
EP 468
DI 10.1146/annurev-physiol-031522-092054
PG 20
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA 9B8YI
UT WOS:000935017000019
PM 36375468
OA hybrid
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Pan, JS
   Zhou, WJ
   Xu, RH
   Xing, LJ
   Ji, G
   Dang, YQ
AF Pan, Jiashu
   Zhou, Wenjun
   Xu, Ruohui
   Xing, Lianjun
   Ji, Guang
   Dang, Yanqi
TI Natural PPARs agonists for the treatment of nonalcoholic fatty liver
   disease
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Review
DE Nonalcoholic fatty liver disease; Peroxisome proliferator activated
   receptors; Natural products; Agonists
ID ACTIVATED RECEPTOR-ALPHA; HEPATIC STEATOSIS; OXIDATIVE STRESS;
   LIPID-METABOLISM; GENE-EXPRESSION; MACROPHAGE POLARIZATION; INFLAMMASOME
   ACTIVATION; NUCLEAR RECEPTORS; SKELETAL-MUSCLE; DUAL AGONIST
AB Nonalcoholic fatty liver disease (NAFLD) is a general term for a series of liver diseases including simple steatosis, non-alcoholic steatohepatitis, liver fibrosis, which is closely related to metabolic syndrome. The pathogenesis of NAFLD is relatively complex, which has gradually changed from the previous 'two-hit' hypothesis to the current "multiple hits" hypothesis. However, there is currently no approved treatment for NAFLD in clinic, highlighting the urgent need for drug development. Peroxisome proliferator activated receptors (PPARs) are members of the nuclear receptor superfamily, whose different subtypes have been proved to regulate different stages of NAFLD, thus becoming promising drug targets for NAFLD. As important sources of drug development, natural products have been proven to treat NAFLD through multiple pathways and multiple targets. In this paper, we outline the regulatory role of PPARs in NAFLD, and summarize some natural products that target PPARs to ameliorate NAFLD, in order to provide reference for drug development of NAFLD.
C1 [Pan, Jiashu; Zhou, Wenjun; Xu, Ruohui; Ji, Guang; Dang, Yanqi] Shanghai Univ Tradit Chinese Med, Longhua Hosp, Inst Digest Dis, China Canada Ctr Res Digest Dis ccCRDD, Shanghai 200032, Peoples R China.
   [Pan, Jiashu; Xing, Lianjun] Shanghai Univ Tradit Chinese Med, Longhua Hosp, Dept Digest Dis, Shanghai 200032, Peoples R China.
C3 Shanghai University of Traditional Chinese Medicine; Shanghai University
   of Traditional Chinese Medicine
RP Ji, G; Dang, YQ (corresponding author), Shanghai Univ Tradit Chinese Med, Longhua Hosp, Inst Digest Dis, China Canada Ctr Res Digest Dis ccCRDD, Shanghai 200032, Peoples R China.
EM jiliver@vip.sina.com; Dangyanqi9022@126.com
RI Zhou, Wenjun/G-1382-2011
OI dang, yanqi/0000-0002-0316-7880
FU Shanghai Rising-Star Program [21QA1409000]; Shanghai Frontier Research
   Base of Disease and Syndrome Biology of Inflammatory cancer
   transformation [2021KJ03-12]
FX Funding This work was supported by the Shanghai Rising-Star Program
   (21QA1409000) , and the Shanghai Frontier Research Base of Disease and
   Syndrome Biology of Inflammatory cancer transformation (2021KJ03-12) .
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NR 111
TC 26
Z9 27
U1 4
U2 57
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD JUL
PY 2022
VL 151
AR 113127
DI 10.1016/j.biopha.2022.113127
EA MAY 2022
PG 7
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA 1S2OR
UT WOS:000803896200010
PM 35598367
OA gold
DA 2025-06-11
ER

PT J
AU Williams, R
   Periasamy, M
AF Williams, Rachel
   Periasamy, Muthu
TI Genetic and Environmental Factors Contributing to Visceral Adiposity in
   Asian Populations
SO ENDOCRINOLOGY AND METABOLISM
LA English
DT Review
DE Intra-abdominal fat; Adiposity; Asian
ID ABDOMINAL FAT DISTRIBUTION; PHYSICAL-ACTIVITY LEVELS; METABOLIC
   SYNDROME; BODY-FAT; GENDER-DIFFERENCES; DIABETES-MELLITUS; CENTRAL
   OBESITY; SOUTH ASIANS; OLDER-ADULTS; EXERCISE
AB Obesity-associated metabolic illnesses are increasing at an alarming rate in Asian countries. A common feature observed in the Asian population is a higher incidence of abdominal obesity-the "skinny-fat" Asian syndrome. In this review, we critically evaluate the relative roles of genetics and environmental factors on fat distribution in Asian populations. While there is an upward trend in obesity among most Asian countries, it appears particularly conspicuous in Malaysia. We propose a novel theory, the Malaysian gene-environment multiplier hypothesis, which explains how ancestral variations in feast-and-famine cycles contribute to inherited genetic predispositions that, when acted on by modern-day stressors-most notably, urbanization, westernization, lifestyle changes, dietary transitions, cultural pressures, and stress-contribute to increased visceral adiposity in Asian populations. At present, the major determinants contributing to visceral adiposity in Asians are far from conclusive, but we seek to highlight critical areas for further research.
C1 [Williams, Rachel; Periasamy, Muthu] Univ Cent Florida, Dept Internal Med, Coll Med, Burnett Sch Biomed Sci, Room 541,6900 Lake Nona Blvd, Orlando, FL 32827 USA.
C3 State University System of Florida; University of Central Florida
RP Periasamy, M (corresponding author), Univ Cent Florida, Dept Internal Med, Coll Med, Burnett Sch Biomed Sci, Room 541,6900 Lake Nona Blvd, Orlando, FL 32827 USA.
EM muthu.periasamy@ucf.edu
OI Periasamy, Muthu/0000-0001-8834-5975; Williams,
   Rachel/0000-0002-0539-3857
FU National Institutes of Health [R01 DK098240-01]; UCF College of Medicine
FX This work was supported in part, by National Institutes of Health Grants
   R01 DK098240-01 and funding from UCF College of Medicine. We would like
   to thank several colleagues, Drs Naresh Bal, Meghna Pant, Shang-Shang
   Gao, Wencai Zhang, and Hung Nguyen, for feedback and critical reading of
   the manuscript. We thank Doque Williams for the artwork included in the
   manuscript.
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NR 82
TC 40
Z9 42
U1 1
U2 9
PU KOREAN ENDOCRINE SOC
PI SEOUL
PA 101-2503, 109 MAPO-DAERO, MAPO-GU, SEOUL, 04146, SOUTH KOREA
SN 2093-596X
EI 2093-5978
J9 ENDOCRINOL METAB
JI Endocrinol. Metab.
PD DEC
PY 2020
VL 35
IS 4
BP 681
EP 695
DI 10.3803/EnM.2020.772
PG 15
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA PR2UO
UT WOS:000607096500002
PM 33397033
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Giampieri, F
   Forbes-Hernandez, TY
   Gasparrini, M
   Afrin, S
   Cianciosi, D
   Reboredo-Rodriguez, P
   Varela-Lopez, A
   Quiles, JL
   Mezzetti, B
   Battino, M
AF Giampieri, Francesca
   Forbes-Hernandez, Tamara Y.
   Gasparrini, Massimiliano
   Afrin, Sadia
   Cianciosi, Danila
   Reboredo-Rodriguez, Patricia
   Varela-Lopez, Alfonso
   Quiles, Jose L.
   Mezzetti, Bruno
   Battino, Maurizio
TI The healthy effects of strawberry bioactive compounds on molecular
   pathways related to chronic diseases
SO ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
LA English
DT Review
DE cancer; cardiovascular diseases; inflammation; metabolism; strawberry
   phenolic compounds
ID PLASMA ANTIOXIDANT STATUS; ANTIINFLAMMATORY ACTIVITY; FLAVONOID FISETIN;
   OXIDATIVE STRESS; INDUCED TOXICITY; HEART-DISEASE; ELLAGIC ACID; CANCER;
   EXTRACT; ANTHOCYANIN
AB It is generally accepted that a fruit and vegetable-enriched diet is favorable for human health. The consumption of strawberries, in particular, has been related to the maintenance of well-being and the prevention of several chronic diseases, owing to the high contents of antioxidants and phytochemicals present in the fruit. Several biological effects have been explained through the total antioxidant capacity exerted by these bioactive compounds, but recentlymore intricate mechanisms have begun to be examined. In this context, it has been reported that strawberry phenolics are able to exert anti-inflammatory, anticarcinogenic, antiproliferative, and antiatherosclerotic activities, acting on specific molecular pathways related to antioxidant defenses, metabolism, survival, and proliferation. The overall aim of this work is to discuss and update the cellular and molecular mechanisms recently proposed to clarify the effects of strawberry phenolics on human health, with particular attention to the most common chronic diseases, such as metabolic syndrome, cardiovascular disease, and cancer.
C1 [Giampieri, Francesca; Forbes-Hernandez, Tamara Y.; Gasparrini, Massimiliano; Afrin, Sadia; Cianciosi, Danila; Reboredo-Rodriguez, Patricia; Varela-Lopez, Alfonso; Battino, Maurizio] Univ Politecn Marche, Dipartimento Sci Clin Specialist & Odontostomatol, Sez Biochim, Fac Med, Via Ranieri 65, I-60131 Ancona, Italy.
   [Forbes-Hernandez, Tamara Y.] Univ Int Iberoamer UNINI, Area Nutr & Salud, Campeche, Mexico.
   [Reboredo-Rodriguez, Patricia] Univ Vigo, Dept Quim Analit & Alimentaria, Grp Nutr & Bromatol, Orense, Spain.
   [Quiles, Jose L.] Univ Granada, Inst Nutr & Food Technol Jose Mataix, Dept Physiol, Biomed Res Ctr, Granada, Spain.
   [Mezzetti, Bruno] Univ Politecn Marche, Dipartimento Sci Agr Alimentari & Ambientali, Ancona, Italy.
   [Battino, Maurizio] UEA, Ctr Nutr & Hlth, Santander, Spain.
C3 Marche Polytechnic University; Universidade de Vigo; University of
   Granada; Marche Polytechnic University
RP Battino, M (corresponding author), Univ Politecn Marche, Dipartimento Sci Clin Specialist & Odontostomatol, Sez Biochim, Fac Med, Via Ranieri 65, I-60131 Ancona, Italy.
EM m.a.battino@univpm.it
RI Battino, Maurizio/E-6103-2012; Afrin, Sadia/AAQ-5030-2020;
   Reboredo-Rodríguez, Patricia/AAH-2388-2019; Mezzetti,
   Bruno/AAB-8500-2019; Cianciosi, Danila/H-7405-2019; Varela-Lopez,
   Alfonso/F-8055-2016; Forbes Hernandez, Tamara/AAB-1872-2021; Giampieri,
   Francesca/I-1911-2015; Quiles, Jose L./C-6911-2013
OI Varela-Lopez, Alfonso/0000-0002-0504-5086; Afrin,
   Sadia/0000-0001-5063-9900; Forbes Hernandez, Tamara/0000-0001-7021-9276;
   Reboredo Rodriguez, Patricia/0000-0001-8440-6347; Giampieri,
   Francesca/0000-0002-8151-9132; Cianciosi, Danila/0000-0002-8781-3535;
   Quiles, Jose L./0000-0002-9048-9086; , IIS Galicia
   Sur/0000-0003-3812-7413; Mezzetti, Bruno/0000-0001-9307-812X
FU Alfonso Martin Escudero Foundation; Xunta de Galicia
FX The authors are indebted to Ms. M. Glebocki for extensive editing of the
   manuscript. Alfonso Varela-Lopez is supported by a fellowship from the
   Alfonso Martin Escudero Foundation. Patricia Reboredo-Rodriguez
   acknowledges Xunta de Galicia for her postdoctoral contract.
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NR 75
TC 52
Z9 54
U1 4
U2 48
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0077-8923
EI 1749-6632
J9 ANN NY ACAD SCI
JI Ann. N.Y. Acad. Sci.
PD JUN
PY 2017
VL 1398
IS 1
SI SI
BP 62
EP 71
DI 10.1111/nyas.13373
PG 10
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA FA5BM
UT WOS:000405457600006
PM 28618011
DA 2025-06-11
ER

PT J
AU Pisano, G
   Lombardi, R
   Fracanzani, AL
AF Pisano, Giuseppina
   Lombardi, Rosa
   Fracanzani, Anna Ludovica
TI Vascular Damage in Patients with Nonalcoholic Fatty Liver Disease:
   Possible Role of Iron and Ferritin
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE NAFLD; ferritin; iron; cardiovascular disease; metabolic syndrome
ID INTESTINAL MICROBIOTA METABOLISM; SERUM FERRITIN; INSULIN-RESISTANCE;
   BODY IRON; CARDIOVASCULAR-DISEASE; BLOOD-DONATION;
   HEPATOCELLULAR-CARCINOMA; INCREASED SUSCEPTIBILITY; ATHEROSCLEROTIC
   PLAQUES; CAROTID ATHEROSCLEROSIS
AB Non Alcoholic Fatty Liver Disease (NAFLD) is the most common chronic liver disease in Western countries. Recent data indicated that NAFLD is a risk factor by itself contributing to the development of cardiovascular disease independently of classical known risk factors. Hyperferritinemia and mild increased iron stores are frequently observed in patients with NAFLD and several mechanisms have been proposed to explain the role of iron, through oxidative stress and interaction with insulin metabolism, in the development of vascular damage. Moreover, iron depletion has been shown to decrease atherogenesis in experimental models and in humans. This review presents the recent evidence on epidemiology, pathogenesis, and the possible explanation of the role of iron and ferritin in the development of cardiovascular damage in patients with NAFLD, and discusses the possible interplay between metabolic disorders associated with NAFLD and iron in the development of cardiovascular disease.
C1 [Pisano, Giuseppina; Lombardi, Rosa; Fracanzani, Anna Ludovica] Univ Milan, Ctr Study Metab & Liver Dis, Ca Granda IRCCS Fdn Policlin Hosp, Dept Pathophysiol & Transplantat, Via Francesco Sforza 35, I-20122 Milan, Italy.
C3 University of Milan
RP Fracanzani, AL (corresponding author), Univ Milan, Ctr Study Metab & Liver Dis, Ca Granda IRCCS Fdn Policlin Hosp, Dept Pathophysiol & Transplantat, Via Francesco Sforza 35, I-20122 Milan, Italy.
EM pinaz81@hotmail.com; rosalombardi@hotmail.it; anna.fracanzani@unimi.it
RI Lombardi, Rosa/AAB-8031-2019; Pisano, Giuseppina/AAB-9234-2019;
   Fracanzani, Anna Ludovica/J-8986-2018
OI Pisano, Giuseppina/0000-0002-7723-3801; Fracanzani, Anna
   Ludovica/0000-0001-5918-0171; Lombardi, Rosa/0000-0001-6958-927X
FU Associazione Malattie Metaboliche Fegato O.N.L.U.S.
FX The authors wish to thank Associazione Malattie Metaboliche Fegato
   O.N.L.U.S. for all the needed support.
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NR 90
TC 13
Z9 14
U1 0
U2 14
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD MAY
PY 2016
VL 17
IS 5
AR 675
DI 10.3390/ijms17050675
PG 12
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA DP9BJ
UT WOS:000378791400069
PM 27164079
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Mahmood, DFD
   Abderrazak, A
   El Hadri, K
   Simmet, T
   Rouis, M
AF Mahmood, Dler Faieeq Darweesh
   Abderrazak, Amna
   El Hadri, Khadija
   Simmet, Thomas
   Rouis, Mustapha
TI The Thioredoxin System as a Therapeutic Target in Human Health and
   Disease
SO ANTIOXIDANTS & REDOX SIGNALING
LA English
DT Review
ID INTERACTING-PROTEIN TXNIP; UP-REGULATED PROTEIN-1; BLOOD
   MONONUCLEAR-CELLS; LEUKEMIA-DERIVED FACTOR; NF-KAPPA-B; HUMAN
   MITOCHONDRIAL THIOREDOXIN; RECOMBINANT HUMAN THIOREDOXIN;
   ISCHEMIA-REPERFUSION INJURY; PROMOTES OXIDATIVE STRESS; EARLY EMBRYONIC
   LETHALITY
AB The thioredoxin (Trx) system comprises Trx, truncated Trx (Trx-80), Trx reductase, and NADPH, besides a natural Trx inhibitor, the thioredoxin-interacting protein (TXNIP). This system is essential for maintaining the balance of the cellular redox status, and it is involved in the regulation of redox signaling. It is also pivotal for growth promotion, neuroprotection, inflammatory modulation, antiapoptosis, immune function, and atherosclerosis. As an ubiquitous and multifunctional protein, Trx is expressed in all forms of life, executing its function through its antioxidative, protein-reducing, and signal-transducing activities. In this review, the biological properties of the Trx system are highlighted, and its implications in several human diseases are discussed, including cardiovascular diseases, heart failure, stroke, inflammation, metabolic syndrome, neurodegenerative diseases, arthritis, and cancer. The last chapter addresses the emerging therapeutic approaches targeting the Trx system in human diseases. Antioxid. Redox Signal. 19, 1266-1303.
C1 [Mahmood, Dler Faieeq Darweesh; Abderrazak, Amna; El Hadri, Khadija; Rouis, Mustapha] Univ Paris 06, UR Aging Stress & Inflammat 04, F-75252 Paris 5, France.
   [Simmet, Thomas] Univ Ulm, Inst Pharmacol Nat Prod & Clin Pharmacol, D-89069 Ulm, Germany.
C3 Sorbonne Universite; Ulm University
RP Rouis, M (corresponding author), Univ Paris 06, Unite Rech, UR Vieillissement Stress & Inflammat 04, Bat A 5Eme Etage Case Courrier 256,7 Quai St Bern, F-75252 Paris 5, France.
EM mustapha.rouis@snv.jussieu.fr
RI Mahmood, Dler/V-5278-2017; de Assis Silveira, Wilian/AAJ-8298-2020;
   Rouis, Mustapha/E-4993-2016; Mahmood, Dler/G-9107-2015
OI Rouis, Mustapha/0000-0003-4197-6555; EL HADRI,
   KHADIJA/0000-0002-1275-9861; Syrovets, Tatiana/0000-0002-6751-2233;
   Mahmood, Dler/0000-0002-6536-1427
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NR 478
TC 241
Z9 272
U1 1
U2 80
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1523-0864
EI 1557-7716
J9 ANTIOXID REDOX SIGN
JI Antioxid. Redox Signal.
PD OCT 10
PY 2013
VL 19
IS 11
BP 1266
EP 1303
DI 10.1089/ars.2012.4757
PG 38
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 224MO
UT WOS:000324891000012
PM 23244617
DA 2025-06-11
ER

PT J
AU Tabaton, M
   Odetti, P
   Cammarata, S
   Borghi, R
   Monacelli, F
   Caltagirone, C
   Bossù, P
   Buscema, M
   Grossi, E
AF Tabaton, Massimo
   Odetti, Patrizio
   Cammarata, Sergio
   Borghi, Roberta
   Monacelli, Fiammetta
   Caltagirone, Carlo
   Bossu, Paola
   Buscema, Massimo
   Grossi, Enzo
TI Artificial Neural Networks Identify the Predictive Values of Risk
   Factors on the Conversion of Amnestic Mild Cognitive Impairment
SO JOURNAL OF ALZHEIMERS DISEASE
LA English
DT Article
DE Alzheimer's disease; artificial neural networks; biological markers;
   mild cognitive impairment
ID ALZHEIMERS-DISEASE; INSULIN-RESISTANCE; METABOLIC SYNDROME; OXIDATIVE
   STRESS; PLASMA; DEMENTIA; PENTOSIDINE; TESTS; MODEL
AB The search for markers that are able to predict the conversion of amnestic mild cognitive impairment (aMCI) to Alzheimer's disease (AD) is crucial for early mechanistic therapies. Using artificial neural networks (ANNs), 22 variables that are known risk factors of AD were analyzed in 80 patients with aMCI, for a period spanning at least 2 years. The cases were chosen from 195 aMCI subjects recruited by four Italian Alzheimer's disease units. The parameters of glucose metabolism disorder, female gender, and apolipoprotein E epsilon 3/epsilon 4 genotype were found to be the biological variables with high relevance for predicting the conversion of aMCI. The scores of attention and short term memory tests also were predictors. Surprisingly, the plasma concentration of amyloid-beta(42) had a low predictive value. The results support the utility of ANN analysis as a new tool in the interpretation of data from heterogeneous and distinct sources.
C1 [Tabaton, Massimo; Odetti, Patrizio; Borghi, Roberta; Monacelli, Fiammetta] Univ Genoa, Dept Internal Med & Med Specialties, I-16132 Genoa, Italy.
   [Cammarata, Sergio] Galliera Hosp, Dept Neurol, Genoa, Italy.
   [Caltagirone, Carlo; Bossu, Paola] IRCCS Santa Lucia Fdn, Dept Clin & Behav Neurol, Rome, Italy.
   [Buscema, Massimo] Semeion Res Ctr, Rome, Italy.
   [Grossi, Enzo] Bracco Med Dept, Milan, Italy.
C3 University of Genoa; Ente Ospedaliero Ospedali Galliera; University of
   Genoa; IRCCS Santa Lucia; Bracco
RP Tabaton, M (corresponding author), Univ Genoa, Dept Internal Med & Med Specialties, I-16132 Genoa, Italy.
EM mtabaton@neurologia.unige.it
RI Caltagirone, Carlo/B-4930-2013; Grossi, Enzo/AAF-7765-2020; MONACELLI,
   FIAMMETTA/K-4198-2016; /E-4832-2014; NACMIAS, Benedetta/J-5084-2018
OI MONACELLI, FIAMMETTA/0000-0003-4303-7252; /0000-0002-1432-0078; ODETTI,
   PATRIZIO/0000-0001-9559-7273; Buscema, Paolo
   Massimo/0000-0003-4356-0510; NACMIAS, Benedetta/0000-0001-9338-9040
FU Bracco Pharma Italy; Italian Minister of Health; Fondazione CARIGE;
   Fondazione CARIPLO
FX The study was supported by Bracco Pharma Italy, Italian Minister of
   Health, Fondazione CARIGE (M.T.) and Fondazione CARIPLO (S.C.).
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NR 33
TC 19
Z9 20
U1 0
U2 5
PU IOS PRESS
PI AMSTERDAM
PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS
SN 1387-2877
EI 1875-8908
J9 J ALZHEIMERS DIS
JI J. Alzheimers Dis.
PY 2010
VL 19
IS 3
BP 1035
EP 1040
DI 10.3233/JAD-2010-1300
PG 6
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 582RU
UT WOS:000276617100023
PM 20157257
DA 2025-06-11
ER

PT J
AU Bhandarkar, NS
   Shetty, K
   Narendra, P
   Kiran, A
   Shetty, R
   Shetty, KB
AF Bhandarkar, Nikhil S.
   Shetty, Keerthy
   Narendra, P.
   Kiran, Anupama
   Shetty, Rohit
   Shetty, K. Bhujang
TI Nutrition and diet for dry eye disease: Insights toward holistic
   management
SO INDIAN JOURNAL OF OPHTHALMOLOGY
LA English
DT Review
DE Diet; dry eye disease; metabolic syndrome
ID RED GINSENG SUPPLEMENTATION; VITAMIN-A-DEFICIENCY; OCULAR SURFACE;
   CALORIE RESTRICTION; OXIDATIVE STRESS; GREEN TEA; FATTY-ACIDS;
   ANTIOXIDANT; INTERVENTION; CATECHINS
AB Dry eye disease (DED) is one of the most common eye problems in the aging population. Hyperosmolarity triggers the immune response in DED and consequently activates the self-perpetuating immune cycle, leading to chronic damage of the ocular surface. This event causes symptoms such as a burning sensation, irritation, redness, photophobia, and blurred vision in DED patients. Subsequently, the quality of life gets significantly affected. The rising demand for DED management and treatment solutions, and the desirable outcomes from innovative therapies that draw global interest provide evidence to demonstrate the role of diet and nutrition in DED. Nutritional deficiency and a Westernized diet contribute to the chronic systemic progression of DED symptoms. It has been revealed in several published studies that the use of nutrients and dietary supplements improves the ocular surface and acts as a protective factor against DED. - We reviewed nutrition and dietary aspects in managing DED and its associated consequences, based on published studies, and reached an evidence-based conclusion.
C1 [Bhandarkar, Nikhil S.] Narayana Nethralaya Eye Hosp, Narayana Nethralaya Fdn, GROW Res Lab, Bangalore, Karnataka, India.
   [Shetty, Keerthy; Narendra, P.; Kiran, Anupama; Shetty, Rohit; Shetty, K. Bhujang] Narayana Nethralaya, Bengaluru, Karnataka, India.
RP Bhandarkar, NS (corresponding author), Narayana Nethralaya, Narayana Nethralaya Fdn, Genes Repair & Regenerat Ophthalm Workstat, Narayana Hlth City,GROW Lab, 3rd Floor,Hosur Rd, Bangalore 560099, Karnataka, India.
EM nikhil.bhandarkar@narayananethralaya.com
RI Bhandarkar, Nikhil/AAV-4263-2020
OI Bhandarkar, Nikhil/0000-0001-8790-8940
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NR 65
TC 1
Z9 1
U1 5
U2 6
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, Maharashtra, INDIA
SN 0301-4738
EI 1998-3689
J9 INDIAN J OPHTHALMOL
JI Indian J. Ophthalmol.
PD OCT
PY 2024
VL 72
IS 10
BP 1412
EP 1423
DI 10.4103/IJO.IJO_2899_22
PG 12
WC Ophthalmology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Ophthalmology
GA J9M2R
UT WOS:001340225400001
PM 39331431
OA gold
DA 2025-06-11
ER

PT J
AU Torres-Benitez, A
   Ortega-Valencia, JE
   Jara-Pinuer, N
   Sanchez, M
   Vargas-Arana, G
   Gómez-Serranillos, MP
   Simirgiotis, MJ
AF Torres-Benitez, Alfredo
   Ortega-Valencia, Jose Erick
   Jara-Pinuer, Nicolas
   Sanchez, Marta
   Vargas-Arana, Gabriel
   Gomez-Serranillos, Maria Pilar
   Simirgiotis, Mario J.
TI Antioxidant and antidiabetic activity and phytoconstituents of lichen
   extracts with temperate and polar distribution
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Article
DE Ochrolechia; Placopsis; Umbilicaria; bioactive compounds; antioxidant;
   enzyme inhibition; Antarctic lichens
ID USNIC ACID; IN-VITRO; SECONDARY METABOLITE; ATRANORIN; DAMAGE
AB The objective of this research was to characterize the chemical composition of ethanolic extracts of the lichen species Placopsis contortuplicata, Ochrolechia frigida, and Umbilicaria antarctica, their antioxidant activity, and enzymatic inhibition through in vitro and molecular docking analysis. In total phenol content, FRAP, ORAC, and DPPH assays, the extracts showed significant antioxidant activity, and in in vitro assays for the inhibition of pancreatic lipase, alpha-glucosidase, and alpha-amylase enzymes, together with in silico studies for the prediction of pharmacokinetic properties, toxicity risks, and intermolecular interactions of compounds, the extracts evidenced inhibitory potential. A total of 13 compounds were identified by UHPLC-ESI-QTOF-MS in P. contortuplicata, 18 compounds in O. frigida, and 12 compounds in U. antarctica. This study contributes to the knowledge of the pool of bioactive compounds present in lichens of temperate and polar distribution and biological characteristics that increase interest in the discovery of natural products that offer alternatives for treatment studies of diseases related to oxidative stress and metabolic syndrome.
C1 [Torres-Benitez, Alfredo; Jara-Pinuer, Nicolas; Simirgiotis, Mario J.] Univ Austral Chile, Fac Ciencias, Inst Farm, Valdivia, Chile.
   [Ortega-Valencia, Jose Erick] Tecnol Nacl Mexico, Inst Tecnol Tlalnepantla, Tlalnepantla Baz, Mexico.
   [Sanchez, Marta; Gomez-Serranillos, Maria Pilar] Univ Complutense Madrid, Fac Farm, Dept Farmacol Farmacognosia & Bot, Madrid, Spain.
   [Vargas-Arana, Gabriel] Inst Invest Amazonia Peruana, Lab Quim Prod Nat, Ave Abelardo Quinones, Iquitos, Peru.
   [Vargas-Arana, Gabriel] Univ Nacl Amazonia Peruana, Fac Ind Alimentarias, Iquitos, Peru.
C3 Universidad Austral de Chile; Complutense University of Madrid;
   Universidad Nacional de la Amazonia Peruana
RP Simirgiotis, MJ (corresponding author), Univ Austral Chile, Fac Ciencias, Inst Farm, Valdivia, Chile.
EM mario.simirgiotis@uach.cl
RI Simirgiotis, Mario/P-3871-2017; Vargas-Arana, Gabriel/ACS-4051-2022;
   Vargas-Arana, Gabriel/F-5270-2017
OI Vargas-Arana, Gabriel/0000-0002-0808-4283
FU This work was supported by the Instituto Antrtico Chileno (grant INACH
   RT 16-17) (MJS), the Spanish Ministry of Science, Innovation, and
   Universities (PID 2019-105312GB-100) (MG-S), and ANID PFCHA/Beca
   Doctorado Nacional/1741/2022 (AT-B). [INACH RT 16-17]; Spanish Ministry
   of Science, Innovation [PID 2019-105312GB-100]
FX This work was supported by the Instituto Antartico Chileno (grant INACH
   RT 16-17) (MJS), the Spanish Ministry of Science, Innovation, and
   Universities (PID 2019-105312GB-100) (MG-S), and ANID PFCHA/Beca
   Doctorado Nacional/1741/2022 (AT-B).r This work was supported by the
   Instituto Antartico Chileno (grant INACH RT 16-17) (MJS), the Spanish
   Ministry of Science, Innovation, and Universities (PID
   2019-105312GB-100) (MG-S), and ANID PFCHA/Beca Doctorado
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NR 72
TC 6
Z9 6
U1 0
U2 8
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD NOV 1
PY 2023
VL 14
AR 1251856
DI 10.3389/fphar.2023.1251856
PG 19
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA Y3ZA3
UT WOS:001104669100001
PM 38026927
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Scuteri, A
   Morrell, CH
   Alghatrif, M
   Orru, M
   Fiorillo, E
   Marongiu, M
   Schlessinger, D
   Cucca, F
   Lakatta, EG
AF Scuteri, Angelo
   Morrell, Christopher H.
   Alghatrif, Majd
   Orru, Marco
   Fiorillo, Edoardo
   Marongiu, Michele
   Schlessinger, David
   Cucca, Francesco
   Lakatta, Edward G.
TI Glucose-6-phosphate dehydrogenase deficiency accelerates arterial aging
   in diabetes
SO ACTA DIABETOLOGICA
LA English
DT Article
DE Aging; Arterial stiffness; Diabetes; Glucose 5 phosphate dehydrogenase;
   Interleukin 6; Pulse wave velocity
ID METABOLIC SYNDROME; CARDIOVASCULAR EVENTS; OXIDATIVE STRESS; STIFFNESS;
   BODY; INHIBITION; MORTALITY; ADIPOSE; MEN
AB AimsHigh glucose levels and Glucose-6-Phosphate Dehydrogenase deficiency (G6PDd) have both tissue inflammatory effects. Here we determined whether G6PDd accelerates arterial aging (information linked stiffening) in diabetes.MethodsPlasma glucose, interleukin 6 (IL6), and arterial stiffness (indexed as carotid-femoral Pulse Wave Velocity, PWV) and red blood cell G6PD activity were assessed in a large (4448) Sardinian population.ResultsAlthough high plasma glucose in diabetics, did not differ by G6DP status (178.2 +/- 55.1 vs 169.0 +/- 50.1 mg/dl) in G6DPd versus non-G6PDd subjects, respectively, IL6, and PWV (adjusted for age and glucose) were significantly increased in G6PDd vs non-G6PDd subjects (PWV, 8.0 +/- 0.4 vs 7.2 +/- 0.2 m/sec) and (IL6, 6.9 +/- 5.0 vs 4.2 +/- 3.0 pg/ml). In non-diabetics, neither fasting plasma glucose, nor IL6, nor PWV were impacted by G6PDd.ConclusionG6PDd in diabetics is associated with increased inflammatory markers and accelerated arterial aging.
C1 [Scuteri, Angelo] Univ Cagliari, Dipartimento Sci Med & Sanita Pubbl, Cagliari, Italy.
   [Scuteri, Angelo] Policlin Univ Monserrato, Internal Med Unit, AOU Cagliari, Cagliari, Italy.
   [Morrell, Christopher H.; Alghatrif, Majd; Lakatta, Edward G.] Natl Inst Aging, Lab Cardiovasc Sci, Intramural Res Program, NIH, Baltimore, MD USA.
   [Alghatrif, Majd] Johns Hopkins Sch Med, Dept Med, Div Cardiol, Baltimore, MD USA.
   [Orru, Marco; Fiorillo, Edoardo; Marongiu, Michele] Consiglio Nazl Ric CNR, Ist Ric Genet & Biomed IRGB, Lanusei, NU, Italy.
   [Schlessinger, David] Natl Inst Aging Intramural Res Program, Lab Genet, NIH, Baltimore, MD USA.
   [Cucca, Francesco] Consiglio Nazl Ric CNR, Ist Ric Genet & Biomed IRGB, Cagliari, Italy.
C3 University of Cagliari; University of Cagliari; Monserrato Polyclinic;
   National Institutes of Health (NIH) - USA; NIH National Institute on
   Aging (NIA); Johns Hopkins University; Johns Hopkins Medicine; Consiglio
   Nazionale delle Ricerche (CNR); Istituto di Ricerca Genetica e Biomedica
   (IRGB-CNR); National Institutes of Health (NIH) - USA; NIH National
   Institute on Aging (NIA); Consiglio Nazionale delle Ricerche (CNR);
   Istituto di Ricerca Genetica e Biomedica (IRGB-CNR)
RP Scuteri, A (corresponding author), Univ Cagliari, Dipartimento Sci Med & Sanita Pubbl, Cagliari, Italy.; Scuteri, A (corresponding author), Policlin Univ Monserrato, Internal Med Unit, AOU Cagliari, Cagliari, Italy.
EM angelo.scuteri@unica.it
RI Lakatta, Edward/AAL-1447-2020; Morrell, Christopher/AAN-3267-2021;
   fiorillo, edoardo/AAY-3804-2020
OI SCUTERI, ANGELO/0000-0003-4784-5441; Marongiu,
   Michele/0000-0002-7289-9815
FU AS: contributed to study conceptualization and to planning of the
   SardiNIA Study; drafted the manuscript. CHM: contributed to data
   analysis. MAG: contributed to study implementation. EF: contributed to
   the recruitment of study participants. MM: contributed
FX AS: contributed to study conceptualization and to planning of the
   SardiNIA Study; drafted the manuscript. CHM: contributed to data
   analysis. MAG: contributed to study implementation. EF: contributed to
   the recruitment of study participants. MM: contributed to data
   collection and cleaning. DS: contributed to Study Funding and to
   planning of the SardiNIA Study. FC: contributed to Study Funding and to
   planning of the SardiNIA Study. EGL: contributed to study
   conceptualization, to Study Funding, and to planning of the SardiNIA:
   Study. All Authors critically reviewed and edited the manuscript and
   subsequently approved the submitted version to be published
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NR 28
TC 2
Z9 2
U1 0
U2 2
PU SPRINGER-VERLAG ITALIA SRL
PI MILAN
PA VIA DECEMBRIO, 28, MILAN, 20137, ITALY
SN 0940-5429
EI 1432-5233
J9 ACTA DIABETOL
JI Acta Diabetol.
PD JAN
PY 2024
VL 61
IS 1
BP 127
EP 130
DI 10.1007/s00592-023-02118-8
EA SEP 2023
PG 4
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA HB1H7
UT WOS:001093111400001
PM 37741911
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU You, JS
   Zhao, MY
   Chen, SM
   Jiang, LH
   Gao, SH
   Yin, H
   Zhao, LM
AF You, Jiangshan
   Zhao, Mengyao
   Chen, Shumin
   Jiang, Lihua
   Gao, Shuhong
   Yin, Hao
   Zhao, Liming
TI Effect of chitooligosaccharides with a specific degree of polymerization
   on multiple targets in T2DM mice
SO BIORESOURCES AND BIOPROCESSING
LA English
DT Article
DE Chitooligosaccharides; Diabetes mellitus; Insulin resistance;
   Hypoglycemic effect
ID CHITOSAN OLIGOSACCHARIDE GO2KA1; ENDOPLASMIC-RETICULUM STRESS;
   PANCREATIC BETA-CELLS; INSULIN-RESISTANCE; SKELETAL-MUSCLE; OBESITY;
   MECHANISMS; ETIOLOGY
AB Chitooligosaccharides (COS) are found naturally in the ocean and present a variety of physiological activities, of which hypoglycemic action has attracted considerable research attention. This study aimed to assess the therapeutic effect of COS on mice suffering from type 2 diabetes mellitus (T2DM). COS effectively reduced blood glucose and blood lipid levels and improved glucose tolerance. Furthermore, COS revealed strong inhibitory activity against alpha-glucosidase, reducing postprandial blood glucose levels. Molecular docking data showed that COS might interact with surrounding amino acids to form a complex and decrease alpha-glucosidase activity. Additionally, COS enhanced insulin signal transduction and glycogen synthesis while restricting gluconeogenesis in the liver and muscles, reducing insulin resistance (IR) as a result. Moreover, COS effectively protected and restored islet cell function to increase insulin secretion. These results indicated that COS exhibited a significant hypoglycemic effect with multi-target participation. Therefore, COS may serve as a new preventive or therapeutic drug for diabetes to alleviate metabolic syndrome.
C1 [You, Jiangshan; Zhao, Mengyao; Chen, Shumin; Jiang, Lihua; Gao, Shuhong; Zhao, Liming] East China Univ Sci & Technol, Sch Biotechnol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China.
   [Yin, Hao] Shanghai Changzheng Hosp, Organ Transplant Ctr, Shanghai 200003, Peoples R China.
   [Zhao, Mengyao; Jiang, Lihua; Zhao, Liming] Shanghai Collaborat Innovat Ctr Biomfg Technol SC, Shanghai 200237, Peoples R China.
C3 East China University of Science & Technology; Naval Medical University
RP Zhao, LM (corresponding author), East China Univ Sci & Technol, Sch Biotechnol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China.; Yin, H (corresponding author), Shanghai Changzheng Hosp, Organ Transplant Ctr, Shanghai 200003, Peoples R China.
EM yinhaoshanghai@163.com; zhaoliming@ecust.edu.cn
RI 赵, 黎明/AHA-1223-2022
OI Zhao, Liming/0000-0002-8523-103X
FU National Key R&D Program of China [2019YFD0901805, 2019YFD090180302];
   National Natural Science Foundation for Young Scientists of China
   [31801668]; Open Project Funding of the State Key Laboratory of
   Bioreactor Engineering, ECUST [ZDXM2019]; Fundamental Research Funds for
   the Central Universities [22221818014]; 111 Project [B18022]
FX This study was endorsed by the National Key R&D Program of China (Grant
   number 2019YFD0901805, 2019YFD090180302), the National Natural Science
   Foundation for Young Scientists of China (No. 31801668), the Open
   Project Funding of the State Key Laboratory of Bioreactor Engineering,
   ECUST (ZDXM2019), the Fundamental Research Funds for the Central
   Universities [Grant number 22221818014], and the 111 Project B18022).
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NR 53
TC 5
Z9 5
U1 9
U2 40
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
EI 2197-4365
J9 BIORESOUR BIOPROCESS
JI Bioresour. Bioprocess.
PD SEP 5
PY 2022
VL 9
IS 1
AR 94
DI 10.1186/s40643-022-00579-3
PG 20
WC Biotechnology & Applied Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology
GA 4H1PQ
UT WOS:000849655000001
PM 38647883
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Zhou, X
   Hu, SS
   Zhang, Y
   Du, GN
   Li, Y
AF Zhou, Xueer
   Hu, Shoushan
   Zhang, Yunan
   Du, Guannan
   Li, Yi
TI The mechanism by which noncoding RNAs regulate muscle wasting in cancer
   cachexia
SO PRECISION CLINICAL MEDICINE
LA English
DT Review
DE cancer cachexia; ncRNA; extracellular vesicles; muscle wasting;
   endoplasmic reticulum stress
ID SKELETAL-MUSCLE; EXTRACELLULAR VESICLES; CELL-PROLIFERATION;
   GENE-EXPRESSION; MICRORNA; EXOSOMES; TARGETS; DIFFERENTIATION;
   TRANSCRIPTION; ATROPHY
AB Cancer cachexia (CC) is a complex metabolic syndrome that accelerates muscle wasting and affects up to 80% of patients with cancer; however, timely diagnostic methods and effective cures are lacking. Although a considerable number of studies have focused on the mechanism of CC-induced muscle atrophy, few novel therapies have been applied in the last decade. In recent years, noncoding RNAs (ncRNAs) have attracted great attention as many differentially expressed ncRNAs in cancer cachectic muscles have been reported to participate in the inhibition of myogenesis and activation of proteolysis. In addition, extracellular vesicles (EVs), which function as ncRNA carriers in intercellular communication, are closely involved in changing ncRNA expression profiles in muscle and promoting the development of muscle wasting; thus, EV-related ncRNAs may represent potential therapeutic targets. This review comprehensively describes the process of ncRNA transmission through EVs and summarizes the pathways and targets of ncRNAs that lead to CC-induced muscle atrophy.
C1 [Li, Yi] Sichuan Univ, West China Hosp Stomatol, State Key Lab Oral Dis, Chengdu 610041, Peoples R China.
   Sichuan Univ, West China Hosp Stomatol, Natl Clin Res Ctr Oral Dis, Chengdu 610041, Peoples R China.
   Sichuan Univ, West China Hosp Stomatol, Dept Head & Neck Oncol, Chengdu 610041, Peoples R China.
C3 Sichuan University; Sichuan University; Sichuan University
RP Li, Y (corresponding author), Sichuan Univ, West China Hosp Stomatol, State Key Lab Oral Dis, Chengdu 610041, Peoples R China.
EM liyi1012@163.com
RI Li, Yi/GWQ-3140-2022
OI Du, Guannan/0000-0002-2755-6311
FU National Natural Science Foundation of China [81972546]; National
   Training Programs of Innovation and Entrepreneurship for Undergraduates
   of China [201910611653]
FX We gratefully acknowledge the financial support from the National
   Natural Science Foundation of China (Grant No. 81972546) and the
   National Training Programs of Innovation and Entrepreneurship for
   Undergraduates of China (Grant No. 201910611653).
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NR 97
TC 6
Z9 6
U1 0
U2 8
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 2096-5303
EI 2516-1571
J9 PRECIS CLIN MED
JI Precis. Clin. Med.
PD JUN
PY 2021
VL 4
IS 2
BP 136
EP 147
DI 10.1093/pcmedi/pbab008
EA APR 2021
PG 12
WC Medicine, Research & Experimental
WE Emerging Sources Citation Index (ESCI)
SC Research & Experimental Medicine
GA WG6QN
UT WOS:000707119200008
PM 35694153
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Chen, MM
   Meng, LH
AF Chen, Man-Man
   Meng, Ling-Hua
TI The double faced role of xanthine oxidoreductase in cancer
SO ACTA PHARMACOLOGICA SINICA
LA English
DT Review
DE xanthine oxidoreductase (XOR); ROS; uric acid; cancer therapy
ID TUMOR LYSIS SYNDROME; SERUM URIC-ACID; OXIDATIVE STRESS; OXIDASE
   INHIBITORS; PROSTATE-CANCER; MAMMARY-GLAND; BREAST-CANCER;
   SUPEROXIDE-DISMUTASE; RAT MODEL; CELL
AB Xanthine oxidoreductase (XOR) is a critical, rate-limiting enzyme that controls the last two steps of purine catabolism by converting hypoxanthine to xanthine and xanthine to uric acid. It also produces reactive oxygen species (ROS) during the catalytic process. The enzyme is generally recognized as a drug target for the therapy of gout and hyperuricemia. The catalytic products uric acid and ROS act as antioxidants or oxidants, respectively, and are involved in pro/anti-inflammatory actions, which are associated with various disease manifestations, including metabolic syndrome, ischemia reperfusion injury, cardiovascular disorders, and cancer. Recently, extensive efforts have been devoted to understanding the paradoxical roles of XOR in tumor promotion. Here, we summarize the expression of XOR in different types of cancer and decipher the dual roles of XOR in cancer by its enzymatic or nonenzymatic activity to provide an updated understanding of the mechanistic function of XOR in cancer. We also discuss the potential to modulate XOR in cancer therapy.
C1 [Chen, Man-Man; Meng, Ling-Hua] Chinese Acad Sci, Shanghai Inst Mat Med, Div Antitumor Pharmacol, Shanghai 201203, Peoples R China.
   [Chen, Man-Man; Meng, Ling-Hua] Univ Chinese Acad Sci, Beijing 100049, Peoples R China.
C3 Chinese Academy of Sciences; Shanghai Institute of Materia Medica, CAS;
   Chinese Academy of Sciences; University of Chinese Academy of Sciences,
   CAS
RP Meng, LH (corresponding author), Chinese Acad Sci, Shanghai Inst Mat Med, Div Antitumor Pharmacol, Shanghai 201203, Peoples R China.; Meng, LH (corresponding author), Univ Chinese Acad Sci, Beijing 100049, Peoples R China.
EM lhmeng@simm.ac.cn
RI Zhou, Shungui/B-3581-2012; meng, linghua/Y-8110-2019
OI Chen, Man/0009-0006-4599-7328
FU National Natural Science Foundation of China [81773760, 81973345]
FX This work was supported by National Natural Science Foundation of China
   [81773760 & 81973345].
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NR 136
TC 24
Z9 27
U1 5
U2 38
PU NATURE PUBL GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1671-4083
EI 1745-7254
J9 ACTA PHARMACOL SIN
JI Acta Pharmacol. Sin.
PD JUL
PY 2022
VL 43
IS 7
BP 1623
EP 1632
DI 10.1038/s41401-021-00800-7
EA NOV 2021
PG 10
WC Chemistry, Multidisciplinary; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Pharmacology & Pharmacy
GA 2Q9OQ
UT WOS:000721428700004
PM 34811515
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Mozos, I
   Flangea, C
   Vlad, DC
   Gug, C
   Mozos, C
   Stoian, D
   Luca, CT
   Horbanczuk, JO
   Horbanczuk, OK
   Atanasov, AG
AF Mozos, Ioana
   Flangea, Corina
   Vlad, Daliborca C.
   Gug, Cristina
   Mozos, Costin
   Stoian, Dana
   Luca, Constantin T.
   Horbanczuk, Jaroslaw O.
   Horbanczuk, Olaf K.
   Atanasov, Atanas G.
TI Effects of Anthocyanins on Vascular Health
SO BIOMOLECULES
LA English
DT Review
DE anthocyanins; arterial stiffness; endothelial function; cardiovascular
   risk; berries; antioxidants
ID CRANBERRY JUICE CONSUMPTION; POPULAR DIETARY-SUPPLEMENT; INTIMA-MEDIA
   THICKNESS; BLOOD ORANGE JUICE; ARTERIAL STIFFNESS; METABOLIC SYNDROME;
   DOUBLE-BLIND; CHOLESTEROL TRANSPORT; POSTMENOPAUSAL WOMEN; ENDOTHELIAL
   FUNCTION
AB Cardiovascular disorders are leading mortality causes worldwide, often with a latent evolution. Vascular health depends on endothelial function, arterial stiffness, and the presence of atherosclerotic plaques. Preventive medicine deserves special attention, focusing on modifiable cardiovascular risk factors, including diet. A diet rich in fruits and vegetables has well-known health benefits, especially due to its polyphenolic components. Anthocyanins, water-soluble flavonoid species, responsible for the red-blue color in plants and commonly found in berries, exert favorable effects on the endothelial function, oxidative stress, inhibit COX-1, and COX-2 enzymes, exert antiatherogenic, antihypertensive, antiglycation, antithrombotic, and anti-inflammatory activity, ameliorate dyslipidemia and arterial stiffness. The present review aims to give a current overview of the mechanisms involved in the vascular protective effect of anthocyanins from the human diet, considering epidemiological data, in vitro and in vivo preclinical research, clinical observational, retrospective, intervention and randomized studies, dietary and biomarker studies, and discussing preventive benefits of anthocyanins and future research directions.
C1 [Mozos, Ioana] Victor Babes Univ Med & Pharm, Ctr Translat Res & Syst Med, Dept Funct Sci Pathophysiol, Timisoara 300173, Romania.
   [Flangea, Corina; Vlad, Daliborca C.] Victor Babes Univ Med & Pharm, Dept Pharmacol & Biochem Pharmacol, Timisoara 300041, Romania.
   [Flangea, Corina; Vlad, Daliborca C.] Timis Cty Emergency Clin Hosp, Timisoara 300723, Romania.
   [Gug, Cristina] Victor Babes Univ Med & Pharm, Dept Microscop Morphol Genet, Timisoara 300041, Romania.
   [Mozos, Costin] Victor Babes Univ Med & Pharm, Fac Med, Timisoara 300042, Romania.
   [Stoian, Dana] Victor Babes Univ Med & Pharm, Dept Internal Med Endocrinol 2, Timisoara 300723, Romania.
   [Luca, Constantin T.] Victor Babes Univ Med & Pharm, Dept Cardiol Cardiol 2, Timisoara 300310, Romania.
   [Luca, Constantin T.] Inst Cardiovasc Dis, Timisoara 300310, Romania.
   [Horbanczuk, Jaroslaw O.; Atanasov, Atanas G.] Polish Acad Sci, Inst Genet & Anim Biotechnol, PL-05552 Jastrzebiec, Magdalenka, Poland.
   [Horbanczuk, Olaf K.] Warsaw Univ Life Sci, Fac Human Nutr, Nowoursynowska 159 C, PL-02776 Warsaw, Poland.
   [Atanasov, Atanas G.] Med Univ Vienna, Ludwig Boltzmann Inst Digital Hlth & Patient Safe, Spitalgasse 23, A-1090 Vienna, Austria.
   [Atanasov, Atanas G.] Univ Vienna, Dept Pharmacognosy, Althanstr 14, A-1090 Vienna, Austria.
C3 Victor Babes University of Medicine & Pharmacy, Timisoara; Victor Babes
   University of Medicine & Pharmacy, Timisoara; Victor Babes University of
   Medicine & Pharmacy, Timisoara; Victor Babes University of Medicine &
   Pharmacy, Timisoara; Victor Babes University of Medicine & Pharmacy,
   Timisoara; Victor Babes University of Medicine & Pharmacy, Timisoara;
   Polish Academy of Sciences; Institute of Genetics & Animal
   Biotechnology, Polish Academy of Sciences; Warsaw University of Life
   Sciences; Medical University of Vienna; University of Vienna
RP Mozos, I (corresponding author), Victor Babes Univ Med & Pharm, Ctr Translat Res & Syst Med, Dept Funct Sci Pathophysiol, Timisoara 300173, Romania.; Luca, CT (corresponding author), Victor Babes Univ Med & Pharm, Dept Cardiol Cardiol 2, Timisoara 300310, Romania.; Luca, CT (corresponding author), Inst Cardiovasc Dis, Timisoara 300310, Romania.; Atanasov, AG (corresponding author), Polish Acad Sci, Inst Genet & Anim Biotechnol, PL-05552 Jastrzebiec, Magdalenka, Poland.; Atanasov, AG (corresponding author), Med Univ Vienna, Ludwig Boltzmann Inst Digital Hlth & Patient Safe, Spitalgasse 23, A-1090 Vienna, Austria.; Atanasov, AG (corresponding author), Univ Vienna, Dept Pharmacognosy, Althanstr 14, A-1090 Vienna, Austria.
EM ioana_mozos@yahoo.com; flangeacorina@yahoo.com; dalivlad@yahoo.com;
   dr.cristina.gug@gmail.com; mozoscostin@gmail.com; stoian.dana@umft.ro;
   costiluca67@yahoo.ro; olav@rocketmail.com; olaf_horbanczuk@sggw.edu.pl;
   Atanas.Atanasov@dhps.lbg.ac.at
RI Mozos, Ioana/AAB-4874-2020; Vlad, Daliborca/KIA-2056-2024; Luca,
   Constantin/LVS-4258-2024; Flangea, Corina/B-8011-2011; Horbanczuk,
   Jaroslaw/ABD-8389-2021; Stoian, Dana/W-4777-2019; Gug,
   Cristina/ABF-4924-2020; Atanasov, Atanas/C-5535-2013
OI Horbanczuk, Olaf/0000-0002-1746-9134; Gug, Cristina/0000-0003-0111-6606;
   Mozos, Ioana/0000-0001-6353-7698; Stoian, Dana/0000-0003-3826-4362;
   Atanasov, Atanas/0000-0003-2545-0967; STOIAN, DANA/0000-0002-0926-9511
FU National Centre for Research and Development (NCBR) of Poland
   [POIR.01.01.01-00-0593/18]
FX Authors Jaroslaw O. Horba ' nczuk and Atanas G. Atanasov acknowledge the
   financial support from: The National Centre for Research and Development
   (NCBR) of Poland (project number POIR.01.01.01-00-0593/18).
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NR 136
TC 64
Z9 65
U1 3
U2 51
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2218-273X
J9 BIOMOLECULES
JI Biomolecules
PD JUN
PY 2021
VL 11
IS 6
AR 811
DI 10.3390/biom11060811
PG 22
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA SX7GO
UT WOS:000665368800001
PM 34070757
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Giammanco, M
   Mazzola, M
   Giammanco, MM
   Tomasello, G
   Carini, F
AF Giammanco, Marco
   Mazzola, Margherita
   Giammanco, Manfredi Marco
   Tomasello, Giovanni
   Carini, Francesco
TI Omega-3 PUFAs and gut microbiota: A preventive approach for colorectal
   cancer
SO JOURNAL OF BIOLOGICAL RESEARCH-BOLLETTINO DELLA SOCIETA ITALIANA DI
   BIOLOGIA SPERIMENTALE
LA English
DT Review
DE omega-3 PUFAs; colorectal cancer; prevention; gut microbiota; Mucosal
   Associated Lymphatic Tissue (MALT)
ID POLYUNSATURATED FATTY-ACIDS; INFLAMMATORY-BOWEL-DISEASE;
   EICOSAPENTAENOIC ACID; METABOLIC SYNDROME; OXIDATIVE STRESS; RESOLVIN
   D2; MARESIN 1; DIET; RISK; BACTERIAL
AB The influence of diet on the composition of the intestinal microbiota and related pathologies has been known for some time. Some classes of nutrients, such as fatty acids belonging to the omega 3 series, have particular effects on the bacteria that make up the intestinal microbiota. omega-3 PUFAs affect the gut microbiota in three different ways: by modulating the type and abundance of intestinal bacteria, by regulate SCFAs levels, and by alter the levels of proinflammatory mediators. Through these modalities, omega-3 PUFAs could be useful for the prevention of intestinal diseases such as Colorectal Cancer (CRC). The ability of omega-3 PUFAs to modulate the intestinal inflammatory response, to preserve the integrity of the intestinal mucosa and to modulate the bacterial composition of the intestine, could be useful as a preventive strategic approach to hinder the development of CRC.
C1 [Giammanco, Marco] Univ Hosp Policlin Paolo Giaccone Palermo, Dept Surg Oncologic & Stomatol Sci DiChirOnS, Palermo, Italy.
   [Mazzola, Margherita; Tomasello, Giovanni; Carini, Francesco] Univ Hosp Policlin Paolo Giaccone Palermo, Inst Human Anat & Histol, Dept Biomed Neurosci & Adv Diagnost, BIND, Via Vespro 137, I-90127 Palermo, Italy.
   [Giammanco, Manfredi Marco] Univ Messina, Med Sch, Dept Human Pathol Adulthood & Childhood G Barresi, Messina, Italy.
C3 University of Messina
RP Mazzola, M (corresponding author), Univ Hosp Policlin Paolo Giaccone Palermo, Inst Human Anat & Histol, Dept Biomed Neurosci & Adv Diagnost, BIND, Via Vespro 137, I-90127 Palermo, Italy.
EM margheritamazzola@hotmail.it
RI Giammanco, Manfredi/LSJ-8637-2024; Giammanco, Marco/M-8876-2016
OI TOMASELLO, GIOVANNI/0000-0002-3071-822X; , Manfredi Marco
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NR 58
TC 1
Z9 1
U1 0
U2 8
PU PAGEPRESS PUBL
PI PAVIA
PA MEDITGROUP, VIA G BELLI, 4, PAVIA, 27100, ITALY
SN 1826-8838
EI 2284-0230
J9 J BIOL RES-BOLL SOC
JI J. Biol. Res.-Boll. Soc. Biol. Sper.
PY 2021
VL 94
IS 2
AR 9954
DI 10.4081/jbr.2021.9954
PG 6
WC Biology
WE Emerging Sources Citation Index (ESCI)
SC Life Sciences & Biomedicine - Other Topics
GA ZU2PV
UT WOS:000769687700010
OA gold
DA 2025-06-11
ER

PT J
AU Brody, GH
   Yu, TY
   Chen, E
   Ehrlich, KB
   Miller, GE
AF Brody, Gene H.
   Yu, Tianyi
   Chen, Edith
   Ehrlich, Katherine B.
   Miller, Gregory E.
TI Racial Discrimination, Body Mass Index, and Insulin Resistance: A
   Longitudinal Analysis
SO HEALTH PSYCHOLOGY
LA English
DT Article
DE African Americans; body mass index; insulin resistance; racism; rural
   population
ID SELF-REPORTED EXPERIENCES; PERCEIVED DISCRIMINATION; METABOLIC SYNDROME;
   HEALTH DISPARITIES; WAIST CIRCUMFERENCE; CARDIOVASCULAR RISK; ALLOSTATIC
   LOAD; ASSOCIATION; OBESITY; STRESS
AB Objective: To examine prospective relations of perceived racial discrimination at ages 16-18 with body mass index (BMI) at ages 19-21 and insulin resistance (IR) at ages 25 and 27 among Black youth in the rural South, and to determine whether BMI connected discrimination to IR as a mediator. Method: Participants were 315 African American adolescents in rural counties in Georgia who provided data on their perceptions of discrimination during adolescence. BMI was measured during a yearly home visit, and a certified phlebotomist drew a fasting blood sample from which IR was measured. Results: The data analysis, with all confounding variables controlled, revealed that, over time, (a) discrimination was associated positively with both BMI and IR; (b) BMI was associated positively with IR; and (c) BMI acted as a mediator connecting discrimination with IR. Conclusions: The findings are consistent with the hypothesis that exposure to discrimination presages IR through its effects on BMI.
C1 [Brody, Gene H.; Yu, Tianyi; Ehrlich, Katherine B.] Univ Georgia, Ctr Family Res, 1095 Coll Stn Rd, Athens, GA 30602 USA.
   [Chen, Edith; Miller, Gregory E.] Northwestern Univ, Dept Psychol, Evanston, IL 60208 USA.
   [Chen, Edith; Miller, Gregory E.] Northwestern Univ, Inst Policy Res, Evanston, IL 60208 USA.
   [Ehrlich, Katherine B.] Univ Georgia, Dept Psychol, Athens, GA 30602 USA.
C3 University System of Georgia; University of Georgia; Northwestern
   University; Northwestern University; University System of Georgia;
   University of Georgia
RP Brody, GH (corresponding author), Univ Georgia, Ctr Family Res, 1095 Coll Stn Rd, Athens, GA 30602 USA.
EM gbrody@uga.edu
RI Ehrlich, Katherine/AAF-4687-2020
OI Yu, Tianyi/0000-0003-3087-1504; Miller, Gregory/0000-0002-7217-1082
FU National Institute of Child Health and Human Development [R01 HD030588];
   National Institute on Drug Abuse [P30 DA027827]
FX This work was supported by award number R01 HD030588 from the National
   Institute of Child Health and Human Development and award number P30
   DA027827 from the National Institute on Drug Abuse. The content is
   solely the responsibility of the authors and does not necessarily
   represent the official views of the National Institutes of Health.
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NR 52
TC 26
Z9 28
U1 0
U2 21
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 0278-6133
EI 1930-7810
J9 HEALTH PSYCHOL
JI Health Psychol.
PD DEC
PY 2018
VL 37
IS 12
BP 1107
EP 1114
DI 10.1037/hea0000674
PG 8
WC Psychology, Clinical; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology
GA HB4OT
UT WOS:000451034200004
PM 30307274
OA Green Accepted, hybrid
DA 2025-06-11
ER

PT J
AU Lundberg, JO
   Carlström, M
   Weitzberg, E
AF Lundberg, Jon O.
   Carlstrom, Mattias
   Weitzberg, Eddie
TI Metabolic Effects of Dietary Nitrate in Health and Disease
SO CELL METABOLISM
LA English
DT Review
ID METFORMIN IMPROVES HYPERGLYCEMIA; MITOCHONDRIAL RESPIRATORY-CHAIN;
   PROTEIN-KINASE ACTIVATION; CHRONIC KIDNEY-DISEASE; NITRIC-OXIDE BIOLOGY;
   INORGANIC NITRATE; BLOOD-PRESSURE; NADPH OXIDASE;
   PULMONARY-HYPERTENSION; INSULIN-RESISTANCE
AB Nitric oxide (NO), generated from L-arginine and oxygen by NO synthases, is a pleiotropic signaling molecule involved in cardiovascular and metabolic regulation. More recently, an alternative pathway for the formation of this free radical has been explored. The inorganic anions nitrate (NO3-) and nitrite (NO2-), originating from dietary and endogenous sources, generate NO bioactivity in a process involving seemingly symbiotic oral bacteria and host enzymes in blood and tissues. The described cardio-metabolic effects of dietary nitrate from experimental and clinical studies include lowering of blood pressure, improved endothelial function, increased exercise performance, and reversal of metabolic syndrome, as well as antidiabetic effects. The mechanisms underlying the salutary metabolic effects of nitrate are being revealed and include interaction with mitochondrial respiration, activation of key metabolic regulatory pathways, and reduction of oxidative stress. Here we review the recent advances in the nitrate-nitrite-NO pathway, focusing on metabolic effects in health and disease.
C1 [Lundberg, Jon O.; Carlstrom, Mattias; Weitzberg, Eddie] Karolinska Inst, Dept Physiol & Pharmacol, S-17177 Stockholm, Sweden.
C3 Karolinska Institutet
RP Lundberg, JO; Carlström, M; Weitzberg, E (corresponding author), Karolinska Inst, Dept Physiol & Pharmacol, S-17177 Stockholm, Sweden.
EM jon.lundberg@ki.se; mattias.carlstrom@ki.se; eddie.weitzberg@ki.se
RI Carlstrom, Mattias/E-7350-2015
OI Carlstrom, Mattias/0000-0001-9923-8729; Lundberg,
   Jon/0000-0002-0174-5210
FU Swedish Heart and Lung Foundation [20170489, 20170124]; Swedish Research
   Council [2015-02880, 2016-01381]; Stockholm City Council, ALF [LS
   2016-1376]; Karolinska Institutet [2-560/2015]; Swedish Research Council
   [2015-02880] Funding Source: Swedish Research Council
FX The authors are supported by grants from the Swedish Heart and Lung
   Foundation (20170489 to J.O.L. and E.W., 20170124 to M.C.) and the
   Swedish Research Council (2015-02880 to E.W., 2016-01381 to M.C.),
   Stockholm City Council, ALF (LS 2016-1376 to E.W.), and Research Funds
   from the Karolinska Institutet (2-560/2015 to M.C.).
CR [Anonymous], ACTA PHYSL OXF
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NR 151
TC 266
Z9 281
U1 3
U2 54
PU CELL PRESS
PI CAMBRIDGE
PA 50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA
SN 1550-4131
EI 1932-7420
J9 CELL METAB
JI Cell Metab.
PD JUL 3
PY 2018
VL 28
IS 1
BP 9
EP 22
DI 10.1016/j.cmet.2018.06.007
PG 14
WC Cell Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Endocrinology & Metabolism
GA GM1SD
UT WOS:000437850800005
PM 29972800
OA Bronze
DA 2025-06-11
ER

PT J
AU Xu, CF
AF Xu, Chengfu
TI Hyperuricemia and nonalcoholic fatty liver disease: from bedside to
   bench and back
SO HEPATOLOGY INTERNATIONAL
LA English
DT Review
DE Non-alcoholic fatty liver disease; Uric acid; Xanthine oxidoreductase
ID SERUM URIC-ACID; NUTRITION EXAMINATION SURVEY; METABOLIC SYNDROME;
   XANTHINE-OXIDASE; HEPATIC STEATOSIS; OXIDATIVE STRESS; POSTMENOPAUSAL
   WOMEN; CHINESE POPULATION; INSULIN-RESISTANCE; NATIONAL-HEALTH
AB Uric acid is the end product of dietary or endogenous purines degradation, and hyperuricemia is one of the most common metabolic disorders. It has been widely accepted that hyperuricemia increases risks of gout, cardiovascular diseases, and type 2 diabetes. A growing body of evidence, comprising a great deal of cross-sectional studies and several prospective ones, also indicates that hyperuricemia is associated with increased prevalence, incidence and disease severity of non-alcoholic fatty liver disease (NAFLD). On the contrary, NAFLD can predict hyperuricemia as well. However, no causal relationship can be drawn from this point. With a well-established relationship between uric acid and NAFLD prevalence as well as disease severity in addition to the role of potential therapeutic target, the prognostic role of uric acid is also worth investigating. Further studies should focus on the prospective role of uric acid on NAFLD progression and its underlying mechanisms, as well as its clinical implications.
C1 [Xu, Chengfu] Zhejiang Univ, Affiliated Hosp 1, Coll Med, Dept Gastroenterol, 79 Qingchun Rd, Hangzhou 310003, Zhejiang, Peoples R China.
C3 Zhejiang University
RP Xu, CF (corresponding author), Zhejiang Univ, Affiliated Hosp 1, Coll Med, Dept Gastroenterol, 79 Qingchun Rd, Hangzhou 310003, Zhejiang, Peoples R China.
EM xiaofu@zju.edu.cn
RI Xu, Chengfu/HTL-9950-2023
OI Xu, Chengfu/0000-0002-6172-1253
FU Zhejiang Provincial Natural Science Foundation of China [LR15H030001];
   National Natural Science Foundation of China [81100278, 81470838];
   International Science and Technology Cooperation Projects of Zhejiang
   Province [2013C24010]; Science Foundation of Health Bureau of Zhejiang
   Province [2012RCA026]
FX This work was supported by the Zhejiang Provincial Natural Science
   Foundation of China (No. LR15H030001), the National Natural Science
   Foundation of China (Nos. 81100278 and 81470838), the International
   Science and Technology Cooperation Projects of Zhejiang Province (No.
   2013C24010), and the Science Foundation of Health Bureau of Zhejiang
   Province (No. 2012RCA026). The funders did not play any role in the
   study design, data collection and analysis, decisions regarding data
   release or manuscript preparation.
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NR 74
TC 39
Z9 41
U1 2
U2 31
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1936-0533
EI 1936-0541
J9 HEPATOL INT
JI Hepatol. Int.
PD MAR
PY 2016
VL 10
IS 2
BP 286
EP 293
DI 10.1007/s12072-015-9682-5
PG 8
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA DG0YM
UT WOS:000371792100007
PM 26671825
DA 2025-06-11
ER

PT J
AU de Oliveira, MR
   Nabavi, SF
   Daglia, M
   Rastrelli, L
   Nabavi, SM
AF de Oliveira, Marcos Roberto
   Nabavi, Seyed Fazel
   Daglia, Maria
   Rastrelli, Luca
   Nabavi, Seyed Mohammad
TI Epigallocatechin gallate and mitochondria-A story of life and death
SO PHARMACOLOGICAL RESEARCH
LA English
DT Review
DE Epigallocatechin gallate; Mitochondria; Polyphenol; Natural compounds
ID GREEN TEA POLYPHENOLS; NF-KAPPA-B; GLYCOGEN-SYNTHASE KINASE-3;
   MESOTHELIOMA CELL-DEATH; OXIDATIVE STRESS; (-)-EPIGALLOCATECHIN GALLATE;
   IN-VITRO; MYOCARDIAL DYSFUNCTION; DEPENDENT APOPTOSIS; SIGNALING
   PATHWAYS
AB Epigallocatechin gallate (EGCG) is a flavonoid belonging to the chemical class of falvan-3-ols (catechins) esterified with gallic acid. It is the main catechin found in green tea (Camellia sinensis L.) accounting for about 50% of its total polyphenols. Extensive research performed in recent years has revealed that green tea demonstrates a wide range of positive biological activities against serious chronic diseases such as cardiovascular and neurodegenerative pathologies, cancer, metabolic syndrome and type 2 diabetes. These protective properties can be traced back to the potent antioxidant and anti-inflammatory activities of EGCG. Recent studies have suggested that it may exert its beneficial effects by modulating mitochondrial functions impacting mitochondrial biogenesis, bioenergetic control (ATP production and anabolism), alteration of the cell cycle, and mitochondria-related apoptosis. This review evaluates recent evidence on the ability of EGCG to exert critical influence on the above mentioned pathways. (C) 2015 Elsevier Ltd. All rights reserved.
C1 [de Oliveira, Marcos Roberto] Fed Univ Mato Grosso UFMT, ICET, Dept Chem, Av Fernando Correa da Costa 2367, BR-78060900 Cuiaba, MT, Brazil.
   [Nabavi, Seyed Fazel; Nabavi, Seyed Mohammad] Baqiyatallah Univ Med Sci, Appl Biotechnol Res Ctr, Tehran, Iran.
   [Daglia, Maria] Univ Pavia, Dept Drug Sci, Med Chem & Pharmaceut Technol Sect, I-27100 Pavia, Italy.
   [Rastrelli, Luca] Univ Salerno, Dipartimento Farm, Via Giovanni Paolo II, I-84084 Fisciano, Italy.
C3 Universidade Federal de Mato Grosso; Universidade Federal de Mato Grosso
   do Sul; Baqiyatallah University of Medical Sciences (BMSU); University
   of Pavia; University of Salerno
RP de Oliveira, MR (corresponding author), Fed Univ Mato Grosso UFMT, ICET, Dept Chem, Av Fernando Correa da Costa 2367, BR-78060900 Cuiaba, MT, Brazil.
EM mrobioq@yahoo.com.br
RI nabavi, seyed fazel/A-2223-2010; Nabavi, Seyed Mohammad/G-5335-2010;
   Daglia, Maria/AAC-9498-2019; Rastrelli, Luca/A-4159-2011; De Oliveira,
   Marcos Roberto/D-7470-2015
OI Daglia, Maria/0000-0002-4870-7713; Rastrelli, Luca/0000-0003-0718-5450;
   De Oliveira, Marcos Roberto/0000-0003-2414-6605
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NR 166
TC 130
Z9 138
U1 2
U2 80
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 1043-6618
EI 1096-1186
J9 PHARMACOL RES
JI Pharmacol. Res.
PD FEB
PY 2016
VL 104
BP 70
EP 85
DI 10.1016/j.phrs.2015.12.027
PG 16
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA DG1QE
UT WOS:000371841800008
PM 26731017
DA 2025-06-11
ER

PT J
AU Watanabe, K
   Oba, K
   Suzuki, T
   Okuyama, Y
   Ouchi, M
   Suzuki, K
   Ohnishi, T
   Hashimoto, M
   Igari, Y
   Nakano, H
AF Watanabe, Kentaro
   Oba, Kenzo
   Suzuki, Tatsuya
   Okuyama, Yuu
   Ouchi, Motoshi
   Suzuki, Kazunari
   Ohnishi, Tetsuro
   Hashimoto, Masao
   Igari, Yoshimasa
   Nakano, Hiroshi
TI Glucose levels during oral glucose tolerance tests and gamma-glutamyl
   transpeptidase are predictors of change from normal to impaired glucose
   tolerance in healthy middle-aged Japanese men
SO ACTA DIABETOLOGICA
LA English
DT Article
DE OGTT; GGT; Impaired glucose tolerance
ID NONALCOHOLIC FATTY LIVER; INSULIN SECRETORY DYSFUNCTION; METABOLIC
   SYNDROME; CARDIOVASCULAR-DISEASE; DIABETES-MELLITUS; OXIDATIVE STRESS;
   FASTING GLUCOSE; RISK; RESISTANCE; ASSOCIATION
AB We evaluated the predictors of the development from normal to impaired glucose tolerance (IGT) in healthy middle-aged Japanese men. Forty male subjects who showed normal glucose tolerance (NGT) levels based on WHO criteria and who had undergone 75-g OGTT annually for 10 years were selected in the database of medical checkups retrospectively, and divided into two groups: those retaining NGT and those that developed IGT. Gamma-glutamyl transpeptidase (GGT) and the glucose levels at 30 and 60 min were significantly associated with the development of IGT in the Cox proportional hazard model. However, other clinical characteristics and the glucose levels at pre-load and at 120 min were not significantly associated with the development of IGT. GGT and the glucose levels at 30 and 60 min after the 75-g glucose load were predictors of development from NGT to IGT in healthy middle-aged Japanese men.
C1 [Watanabe, Kentaro; Oba, Kenzo; Suzuki, Tatsuya; Okuyama, Yuu; Ouchi, Motoshi; Suzuki, Kazunari; Ohnishi, Tetsuro; Hashimoto, Masao; Igari, Yoshimasa; Nakano, Hiroshi] Nippon Med Sch, Dept Internal Med, Div Cardiol, Bunkyo Ku, Tokyo 1138603, Japan.
   [Watanabe, Kentaro; Oba, Kenzo; Suzuki, Tatsuya; Okuyama, Yuu; Ouchi, Motoshi; Suzuki, Kazunari; Ohnishi, Tetsuro; Hashimoto, Masao; Igari, Yoshimasa; Nakano, Hiroshi] Nippon Med Sch, Div Hepatol, Dept Internal Med, Bunkyo Ku, Tokyo 1138603, Japan.
   [Watanabe, Kentaro; Oba, Kenzo; Suzuki, Tatsuya; Okuyama, Yuu; Ouchi, Motoshi; Suzuki, Kazunari; Ohnishi, Tetsuro; Hashimoto, Masao; Igari, Yoshimasa; Nakano, Hiroshi] Nippon Med Sch, Div Geriatr, Dept Internal Med, Bunkyo Ku, Tokyo 1138603, Japan.
   [Watanabe, Kentaro; Oba, Kenzo; Suzuki, Tatsuya; Okuyama, Yuu; Ouchi, Motoshi; Suzuki, Kazunari; Ohnishi, Tetsuro; Hashimoto, Masao; Igari, Yoshimasa; Nakano, Hiroshi] Nippon Med Sch, Div Integrated Med, Dept Internal Med, Bunkyo Ku, Tokyo 1138603, Japan.
C3 Nippon Medical School; Nippon Medical School; Nippon Medical School;
   Nippon Medical School
RP Watanabe, K (corresponding author), Nippon Med Sch, Dept Internal Med, Div Cardiol, Bunkyo Ku, 1-1-5 Sendagi, Tokyo 1138603, Japan.
EM kentaro@nms.ac.jp
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   World Health Organization, 1985, WHO TECH REP SER, V727
NR 28
TC 2
Z9 2
U1 0
U2 2
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0940-5429
J9 ACTA DIABETOL
JI Acta Diabetol.
PD SEP
PY 2010
VL 47
IS 3
BP 225
EP 230
DI 10.1007/s00592-009-0122-7
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 631TS
UT WOS:000280372600006
PM 19390773
DA 2025-06-11
ER

PT J
AU Stankov, MV
   Behrens, GMN
AF Stankov, Metodi V.
   Behrens, Georg M. N.
TI Contribution of Inflammation to Fat Redistribution and Metabolic
   Disturbances in HIV-1 Infected Patients
SO CURRENT PHARMACEUTICAL DESIGN
LA English
DT Review
DE Antiretroviral therapy; HIV-1; fat redistribution; metabolic syndrome;
   chronic inflammation
ID TUMOR-NECROSIS-FACTOR; C-REACTIVE PROTEIN; ACTIVE ANTIRETROVIRAL
   THERAPY; INDUCED INSULIN-RESISTANCE; ENDOPLASMIC-RETICULUM STRESS;
   IMMUNODEFICIENCY-VIRUS INFECTION; REVERSE-TRANSCRIPTASE INHIBITORS;
   SUBCUTANEOUS ADIPOCYTE APOPTOSIS; HIV-LIPODYSTROPHY SYNDROME;
   ADIPOSE-TISSUE
AB Antiretroviral therapy (ART) has significantly reduced the morbidity and mortality of patients infected with the human immunodeficiency virus 1 (HIV-1). In a significant number of patients, ART is associated with fat redistribution and metabolic alterations such as dyslipidemia, insulin resistance (IR) and type 2 diabetes, summarized under the term HIV-associated lipodystrophy syndrome (HIV-LS). The pathogenesis of HIV-LS is complex and involves a number of factors including ART, HIV-1, abnormal fat redistribution, metabolic abnormalities and chronic inflammation. In view of a novel understanding on how chronic inflammation contributes to the pathogenesis of HIV-1 infection, this review focuses on the interaction of the immune system and metabolic pathways and the potential consequences for the HIV-LS. Based on the current literature, we suggest a central role of systemic inflammation in triggering and deteriorating various components of the HIV-LS.
C1 [Stankov, Metodi V.; Behrens, Georg M. N.] Hannover Med Sch, Clin Immunol & Rheumatol, D-30625 Hannover, Germany.
C3 Hannover Medical School
RP Behrens, GMN (corresponding author), Hannover Med Sch, Clin Immunol & Rheumatol, Carl Neuberg Str 1, D-30625 Hannover, Germany.
EM behrens.georg@mh-hannover.de
RI Behrens, Georg/Q-4486-2016
OI Stankov, Metodi/0000-0003-3001-2478
FU German Research Foundation [EXC 62/1]; Minister for Education and
   Research (Competence Network HIV/AIDS); H.W. & J. Hector Foundation;
   German AIDS-Society; Bristol Myers Squibb; Abbott
FX Prof. Behrens has received grant support by the German Research
   Foundation (EXC 62/1), the Minister for Education and Research
   (Competence Network HIV/AIDS), the H.W. & J. Hector Foundation, the
   German AIDS-Society, Bristol Myers Squibb and Abbott. He received
   honoraria as speaker and/or advisor from Abbott, Boehringer-Ingelheim,
   Bristol-Myers Squibb, Gilead Sciences, GlaxoSmithKline, Merck, Pfizer,
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NR 142
TC 11
Z9 11
U1 0
U2 3
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1381-6128
EI 1873-4286
J9 CURR PHARM DESIGN
JI Curr. Pharm. Design
PY 2010
VL 16
IS 30
BP 3361
EP 3371
PG 11
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 688BP
UT WOS:000284824500004
PM 20687889
DA 2025-06-11
ER

PT J
AU Cárdenas, G
   Torres, JC
   Zamora, J
   Pérez, I
   Baños, G
AF Cárdenas, G
   Torres, JC
   Zamora, J
   Pérez, I
   Baños, G
TI Isolated heart function after ischemia and reperfusion in sucrose-fed
   rats:: Influence of gender and treatment
SO CLINICAL AND EXPERIMENTAL HYPERTENSION
LA English
DT Article
DE experimental hypertension; rat heart ischemia-reperfusion; sucrose-fed
   rats
ID IMPROVED LIPOLYTIC EFFICIENCY; HYPERTENSIVE-RATS; VASCULAR REACTIVITY;
   ENZYMATIC DETERMINATION; ENDOTHELIAL FUNCTION; CREATINE-KINASE;
   SEX-HORMONES; IN-VIVO; SERUM; FEMALE
AB Sucrose-fed rats (HTG) develop hypertension, hypertriglyceridemia, and other features of the metabolic syndrome. This condition, nowadays a world epidemic, is more prevalent in males and increases the risk of cardiovascular diseases. Weanling male and female rats were given either tap water in control (C) or 30% sucrose solution in HTG groups and commercial rat chow for 3, 5, or 8 months. We studied possible variations in cardiac function, due to gender and length of treatment, in isolated heart after ischemia-reperfusion, since an impaired performance may be more easily detected under stress. Together, sucrose treatment and age affected all cardiac variables. Gender had significant effect on coronary vascular resistance and postischemic levels of the enzyme CK-MB; the percentages of retained cardiac enzymes after ischemia were higher in C and HTG females. C and HTG males had a higher incidence of arrhythmias than females, but only HTG males suffered lethal ventricular fibrillation.
C1 Inst Nacl Cardiol Ignacio Chavez, Dept Biochem, Mexico City 14080, DF, Mexico.
   Inst Nacl Cardiol Ignacio Chavez, Dept Pharmacol, Mexico City 14080, DF, Mexico.
   Inst Nacl Cardiol Ignacio Chavez, Dept Endocrinol, Mexico City 14080, DF, Mexico.
   Inst Nacl Cardiol Ignacio Chavez, Dept Pathol, Mexico City 14080, DF, Mexico.
C3 National Institute of Cardiology - Mexico; National Institute of
   Cardiology - Mexico; National Institute of Cardiology - Mexico; National
   Institute of Cardiology - Mexico
RP Inst Nacl Cardiol Ignacio Chavez, Dept Biochem, Juan Badiano 1, Mexico City 14080, DF, Mexico.
EM gbanos@yahoo.com
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NR 48
TC 9
Z9 10
U1 0
U2 5
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1064-1963
EI 1525-6006
J9 CLIN EXP HYPERTENS
JI Clin. Exp. Hypertens.
PD FEB
PY 2006
VL 28
IS 2
BP 85
EP 107
DI 10.1080/10641960500468235
PG 23
WC Pharmacology & Pharmacy; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Cardiovascular System & Cardiology
GA 013LQ
UT WOS:000235411200002
PM 16546836
DA 2025-06-11
ER

PT J
AU Johnson, RJ
   Sánchez-Lozada, LG
   Nakagawa, T
   Rodriguez-Iturbe, B
   Tolan, D
   Gaucher, EA
   Andrews, P
   Lanaspa, MA
AF Johnson, Richard J.
   Sanchez-Lozada, Laura G.
   Nakagawa, Takahiko
   Rodriguez-Iturbe, Bernardo
   Tolan, Dean
   Gaucher, Eric A.
   Andrews, Peter
   Lanaspa, Miguel A.
TI Do thrifty genes exist? Revisiting uricase
SO OBESITY
LA English
DT Review
ID OXIDATIVE STRESS; BLOOD-PRESSURE; ASYMPTOMATIC HYPERURICEMIA; METABOLIC
   SYNDROME; URATE OXIDASE; BREEDER RATS; ALL-CAUSE; ACID; FRUCTOSE;
   ALLOPURINOL
AB Sixty years ago, the geneticist James Neel proposed that the epidemics of obesity and diabetes today may have evolutionary roots. Specifically, he suggested that our ancestors may have accumulated mutations during periods of famine that provided a survival advantage at that time. However, the presence of this "thrifty genotype" in today's world, where food is plentiful, would predispose us to obesity and diabetes. The "thrifty gene" hypothesis, attractive to some, has been challenged over the years. The authors have previously postulated that the loss of the uricase gene, resulting in a rise in serum and intracellular uric acid levels, satisfies the criteria of a thrifty genotype mutation. This paper reviews and brings up-to-date the evidence supporting the hypothesis and discusses the current arguments that challenge this hypothesis. Although further studies are needed to test the hypothesis, the evidence supporting a loss of uricase as a thrifty gene is substantial and supports a role for evolutionary biology in the pathogenesis of the current obesity and diabetes epidemics.
C1 [Johnson, Richard J.; Lanaspa, Miguel A.] Univ Colorado, Div Renal Dis & Hypertens, Anschutz Med Campus,12700 East 19th Ave, Aurora, CO 80045 USA.
   [Sanchez-Lozada, Laura G.] Natl Inst Cardiol Ignacio Chavez, Dept Cardiorenal Physiopathol, Mexico City, DF, Mexico.
   [Nakagawa, Takahiko] Rakuwakai Otowa Hosp, Div Nephrol, Kyoto, Japan.
   [Rodriguez-Iturbe, Bernardo] Salvador Zubiran Natl Inst Hlth Sci & Nutr, Mexico City, DF, Mexico.
   [Rodriguez-Iturbe, Bernardo] Natl Inst Cardiol Ignacio Chavez, Mexico City, DF, Mexico.
   [Tolan, Dean] Boston Univ, Biol Dept, Boston, MA 02215 USA.
   [Gaucher, Eric A.] Georgia State Univ, Dept Biol, Atlanta, GA USA.
   [Andrews, Peter] Nat Hist Museum, Dept Earth Sci, London, England.
   [Lanaspa, Miguel A.] Oregon Hlth & Sci Univ, Div Nephrol, Portland, OR 97201 USA.
C3 University of Colorado System; University of Colorado Anschutz Medical
   Campus; National Institute of Cardiology - Mexico; National Institute of
   Cardiology - Mexico; Boston University; University System of Georgia;
   Georgia State University; Natural History Museum London; Oregon Health &
   Science University
RP Johnson, RJ (corresponding author), Univ Colorado, Div Renal Dis & Hypertens, Anschutz Med Campus,12700 East 19th Ave, Aurora, CO 80045 USA.
EM richard.johnson@cuanschutz.edu
RI Sanchez-Lozada, Laura/AAS-2104-2021; Rodriguez-Iturbe,
   Bernardo/KFX-2910-2024; Lanaspa, Miguel/AAO-4971-2020
OI Johnson, Richard/0000-0003-3312-8193; Tolan, Dean/0000-0002-0598-7241
FU National Institute of Diabetes and Digestive and Kidney Diseases
   [DK121496]; National Institute of Diabetes and Digestive and Kidney
   Diseases [R01DK121496] Funding Source: NIH RePORTER
FX National Institute of Diabetes and Digestive and Kidney Diseases,
   Grant/Award Number: DK121496
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NR 107
TC 14
Z9 17
U1 1
U2 24
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1930-7381
EI 1930-739X
J9 OBESITY
JI Obesity
PD OCT
PY 2022
VL 30
IS 10
BP 1917
EP 1926
DI 10.1002/oby.23540
PG 10
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 4U9SZ
UT WOS:000859126800003
PM 36150210
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Forrester, SN
   Leoutsakos, JM
   Gallo, JJ
   Thorpe, RJ
   Seeman, TE
AF Forrester, Sarah N.
   Leoutsakos, Jeannie-Marie
   Gallo, Joseph J.
   Thorpe, Roland J.
   Seeman, Teresa E.
TI Association between allostatic load and health behaviours: a latent
   class approach
SO JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH
LA English
DT Article
ID NUTRITION EXAMINATION SURVEY; METABOLIC SYNDROME; PHYSICAL-ACTIVITY;
   NATIONAL-HEALTH; ALCOHOL-CONSUMPTION; PATTERNS; WOMEN; DYSREGULATION;
   INFLAMMATION; STRESS
AB Background Allostatic load (AL) has been characterised in many ways throughout the literature; however, its relationship to health behaviours has only been studied in limited populations. We aimed to uncover qualitative patterns of biological indicators in AL and determine if those patterns were associated with certain health behaviours.
   Methods We conducted latent class analysis using biological indicators from a multiethnic population. We fit latent class regression of class on health behaviours (smoking, poor diet, physical activity and alcohol use) to measure the association between each latent class of AL and each health behaviour.
   Results Four classes, ' Metabolic+ Cholesterol, ' Blood Pressure', ' Metabolic+ Blood Pressure' and ' Low', were found in the sample. Latent class regression showed that physical activity and alcohol use were significantly associated with the ' Metabolic+ Blood Pressure' class.
   Conclusion Less physical activity was required to improve AL than was previously found. Low to moderate alcohol use was beneficial for lower AL. Implications of the amount of physical activity necessary to lower AL is discussed.
C1 [Forrester, Sarah N.] Univ Massachusetts, Med Sch, Quantitat Hlth Sci, Worcester, MA USA.
   [Leoutsakos, Jeannie-Marie] Johns Hopkins Univ, Sch Med, Dept Neuropsychiat, Baltimore, MD USA.
   [Gallo, Joseph J.] Johns Hopkins Univ, Dept Mental Hlth, Bloomberg Sch Publ Hlth, Baltimore, MD USA.
   [Thorpe, Roland J.] Johns Hopkins Bloomberg Sch Publ Hlth, Hlth Behav & Soc, Baltimore, MD USA.
   [Seeman, Teresa E.] Univ Calif Los Angeles, Los Angeles Geffen Sch Med, Los Angeles, CA USA.
C3 University of Massachusetts System; University of Massachusetts
   Worcester; Johns Hopkins University; Johns Hopkins University; Johns
   Hopkins Bloomberg School of Public Health; Johns Hopkins University;
   Johns Hopkins Bloomberg School of Public Health; University of
   California System; University of California Los Angeles; University of
   California Los Angeles Medical Center; David Geffen School of Medicine
   at UCLA
RP Forrester, SN (corresponding author), Univ Massachusetts, Sch Med, Quantitat Hlth Sci Dept, Worcester, MA 01605 USA.
EM sarah.forrester@umassmed.edu
RI Forrester, Sarah/AEP-2280-2022
OI Forrester, Sarah/0000-0002-3865-4400; Leoutsakos,
   Jeannie-Marie/0000-0002-1010-1046
FU National Institutes of Health [5TL1TR001454-03]
FX This work was supported by National Institutes of Health (grant number
   5TL1TR001454-03).
CR Ainsworth BE, 1999, J WOMEN HEALTH GEN-B, V8, P805, DOI 10.1089/152460999319129
   [Anonymous], 2008, PHYS ACT GUID AM
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   [Anonymous], 2013, STATA STAT SOFTW REL
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NR 33
TC 32
Z9 38
U1 1
U2 9
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 0143-005X
EI 1470-2738
J9 J EPIDEMIOL COMMUN H
JI J. Epidemiol. Community Health
PD APR
PY 2019
VL 73
IS 4
BP 340
EP 345
DI 10.1136/jech-2018-211289
PG 6
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA ID7FR
UT WOS:000471848000009
PM 30700494
DA 2025-06-11
ER

PT J
AU Quijano, C
   Trujillo, M
   Castro, L
   Trostchansky, A
AF Quijano, Celia
   Trujillo, Madia
   Castro, Laura
   Trostchansky, Andres
TI Interplay between oxidant species and energy metabolism
SO REDOX BIOLOGY
LA English
DT Article
DE Reactive oxygen species; Energy metabolism; Mitochondria; Reactive
   nitrogen species
ID ALPHA-KETOGLUTARATE DEHYDROGENASE; MANGANESE SUPEROXIDE-DISMUTASE;
   HYDROGEN-PEROXIDE GENERATION; ACYL-COA OXIDASE; MITOCHONDRIAL
   ELECTRON-TRANSPORT; PENTOSE-PHOSPHATE PATHWAY; NITRIC-OXIDE; OXIDATIVE
   STRESS; CYTOCHROME-C; XANTHINE-OXIDASE
AB It has long been recognized that energy metabolism is linked to the production of reactive oxygen species (ROS) and critical enzymes allied to metabolic pathways can be affected by redox reactions. This interplay between energy metabolism and ROS becomes most apparent during the aging process and in the onset and progression of many age-related diseases (i.e. diabetes, metabolic syndrome, atherosclerosis, neurodegenerative diseases). As such, the capacity to identify metabolic pathways involved in ROS formation, as well as specific targets and oxidative modifications is crucial to our understanding of the molecular basis of age-related diseases and for the design of novel therapeutic strategies. Herein we review oxidant formation associated with the cell's energetic metabolism, key antioxidants involved in ROS detoxification, and the principal targets of oxidant species in metabolic routes and discuss their relevance in cell signaling and age-related diseases. (C) 2015 The Authors. Published by Elsevier B.V.
C1 [Quijano, Celia; Trostchansky, Andres] Univ Republica, Dept Bioquim, Fac Med, Ave Gen Flores 2125, Montevideo 11800, Uruguay.
   Univ Republica, Ctr Free Rad & Biomed Res, Fac Med, Ave Gen Flores 2125, Montevideo 11800, Uruguay.
C3 Universidad de la Republica, Uruguay; Universidad de la Republica,
   Uruguay
RP Quijano, C; Trostchansky, A (corresponding author), Univ Republica, Dept Bioquim, Fac Med, Ave Gen Flores 2125, Montevideo 11800, Uruguay.
EM celiq@fmed.edu.uy; trocha@fmed.edu.uy
RI Trujillo, Madia/HPE-7504-2023; Trostchansky, Andres/I-5624-2019
OI Trujillo, Madia/0000-0003-2087-017X; Trostchansky,
   Andres/0000-0002-9721-7577
FU Fondo Clemente Estable-ANII [FCE_6353, FCE_6381]; CSIC grupos I + D
   [536, 767]; CSIC I + D [47]; Espacio Interdisciplinario - Centros,
   UDELAR
FX This work was supported by Grants from Fondo Clemente Estable-ANII
   (FCE_6353) and CSIC grupos I + D 2014 (536) to AT; Fondo Clemente
   Estable-ANII (FCE_6381) and CSIC I + D 2012 (ID 47) to CQ; CSIC grupos I
   + D 2014 (767) to MT and LC; and Espacio Interdisciplinario - Centros,
   UDELAR 2015 to CQ MT, LC and AT.
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NR 265
TC 234
Z9 263
U1 2
U2 64
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 2213-2317
J9 REDOX BIOL
JI Redox Biol.
PD AUG
PY 2016
VL 8
BP 28
EP 42
DI 10.1016/j.redox.2015.11.010
PG 15
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA DN9UU
UT WOS:000377427000005
PM 26741399
OA gold, Green Published
DA 2025-06-11
ER

PT S
AU Weglicki, WB
AF Weglicki, William B.
BE Cousins, RJ
TI Hypomagnesemia and Inflammation: Clinical and Basic Aspects
SO ANNUAL REVIEW OF NUTRITION, VOL 32
SE Annual Review of Nutrition
LA English
DT Review; Book Chapter
DE C reactive protein; cytokines; neuropeptides; diabetes; oxidative
   stress; antioxidants
ID C-REACTIVE PROTEIN; IMPROVES INSULIN SENSITIVITY; ACUTE
   MAGNESIUM-DEFICIENCY; BLOOD-CELL GLUTATHIONE; SUBSTANCE-P; DIETARY
   MAGNESIUM; DIABETES-MELLITUS; SERUM MAGNESIUM; MG-DEFICIENCY; NEUROGENIC
   INFLAMMATION
AB In recent years, increasing awareness of hypomagnesemia has resulted in clinical trials that associate this mineral deficiency with diabetes, metabolic syndrome, and drug therapies for cancer and cardiovascular diseases. However, diagnostic testing for tissue deficiency of magnesium still presents a challenge. Investigations of animal and cellular responses to magnesium deficiency have found evidence of complex proinflammatory pathways that may lead to greater understanding of mediators of the pathobiology in neuronal, cardiovascular, intestinal, renal, and hematological tissues. The roles of free radicals, cytokines, neuropeptides, endotoxin, endogenous antioxidants, and vascular permeability, and interventions to limit the inflammatory response associated with these parameters, are outlined in basic studies of magnesium deficiency. It is hoped that this limited review of inflammation associated with some diseases complicated by magnesium deficiency will prompt greater awareness by clinicians and other health providers and in turn increase efforts to prevent and treat this disorder.
C1 George Washington Univ, Sch Med & Hlth Sci, Dept Biochem & Mol Biol, Div Expt Med, Washington, DC 20037 USA.
C3 George Washington University
RP Weglicki, WB (corresponding author), George Washington Univ, Sch Med & Hlth Sci, Dept Biochem & Mol Biol, Div Expt Med, Washington, DC 20037 USA.
EM phywbw@gwumc.edu
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NR 156
TC 68
Z9 79
U1 0
U2 23
PU ANNUAL REVIEWS
PI PALO ALTO
PA 4139 EL CAMINO WAY, PO BOX 10139, PALO ALTO, CA 94303-0897 USA
SN 0199-9885
EI 1545-4312
BN 978-0-8243-2832-0
J9 ANNU REV NUTR
JI Annu. Rev. Nutr.
PY 2012
VL 32
BP 55
EP +
DI 10.1146/annurev-nutr-071811-150656
PG 19
WC Nutrition & Dietetics
WE Book Citation Index – Science (BKCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA BBR29
UT WOS:000307963100004
PM 22404119
DA 2025-06-11
ER

PT J
AU James, RW
AF James, Richard W.
TI A long and winding road: defining the biological role and clinical
   importance of paraoxonases
SO CLINICAL CHEMISTRY AND LABORATORY MEDICINE
LA English
DT Review
DE high-density lipoproteins; innate immunity; lactonase; oxidative stress;
   quorum quenching; toxicology; vascular disease
ID HIGH-DENSITY-LIPOPROTEIN; SERUM PARAOXONASE; OXIDATIVE MODIFICATION;
   DIABETES-MELLITUS; FAMILIAL HYPERCHOLESTEROLEMIA;
   CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; MOLECULAR-BASIS; MOUSE
   MODEL; A-ESTERASE
AB Paraoxonase- 1 (PON1) is an enzyme belonging to a three-member gene family, each of which is highly conserved in mammalian evolution. Whilst there is consensus that the paraoxonase family members have a general protective influence, their precise biological role has remained elusive. A toxicological role, protecting from environmental poisoning by organophosphate derivatives, drove much of the earlier work on the enzymes. More recently, clinical interest has focused on a protective role in vascular disease via a hypothesised impact on lipoprotein lipid oxidation. Recent confirmation that the primary activity of the paraoxonases is that of a lactonase considerably expands the potential sources of biological substrates for the enzyme. Studies on such substrates may shed further light on different mechanisms by which paraoxonases beneficially influence atherosclerosis, as well as defining possible roles in limiting bacterial infection and in innate immunity.
C1 Univ Hosp Geneva, Serv Endocrinol Diabet & Nutr, Clin Diabet Unit, CH-1211 Geneva 14, Switzerland.
C3 University of Geneva
RP James, RW (corresponding author), Univ Hosp Geneva, Serv Endocrinol Diabet & Nutr, Clin Diabet Unit, 24 Rue Micheli Du Crest, CH-1211 Geneva 14, Switzerland.
EM richard.james@hcuge.ch
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NR 86
TC 76
Z9 84
U1 1
U2 4
PU WALTER DE GRUYTER GMBH
PI BERLIN
PA GENTHINER STRASSE 13, D-10785 BERLIN, GERMANY
SN 1434-6621
EI 1437-4331
J9 CLIN CHEM LAB MED
JI Clin. Chem. Lab. Med.
PD SEP
PY 2006
VL 44
IS 9
BP 1052
EP 1059
DI 10.1515/CCLM.2006.207
PG 8
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA 093TT
UT WOS:000241193800002
PM 16958594
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Barsom, SH
   Glasstetter, LM
   Siddiqi, S
   Rajagopalan, KS
   Eirin, A
   Lerman, LO
AF Barsom, Samer H.
   Glasstetter, Logan M.
   Siddiqi, Sarosh
   Rajagopalan, Kamalnath Sankaran
   Eirin, Alfonso
   Lerman, Lilach O.
TI Emergent players in renovascular disease
SO CLINICAL SCIENCE
LA English
DT Review
ID RENAL-ARTERY STENOSIS; MESENCHYMAL STEM-CELLS; KIDNEY INJURY MOLECULE-1;
   MAGNETIC-RESONANCE ELASTOGRAPHY; ENDOTHELIAL PROGENITOR CELLS;
   SHEAR-WAVE ELASTOGRAPHY; ENERGY SHOCK-WAVE; GROWTH-FACTOR; OXIDATIVE
   STRESS; THERAPEUTIC ANGIOGENESIS
AB Renovascular disease (RVD) remains a common etiology of secondary hypertension. Recent clinical trials revealed unsatisfactory therapeutic outcomes of renal revascularization, leading to extensive investigation to unravel key pathophysiological mechanisms underlying irreversible functional loss and structural damage in the chronically ischemic kidney. Research studies identified complex interactions among various players, including inflammation, fibrosis, mitochondrial injury, cellular senescence, and microvascular remodeling. This interplay resulted in a shift of our understanding of RVD from a mere hemodynamic disorder to a pro-inflammatory and pro-fibrotic pathology strongly influenced by systemic diseases like metabolic syndrome (MetS), hypertension, diabetes mellitus, and hyperlipidemia. Novel diagnostic approaches have been tested for early detection and follow-up of RVD progression, using new imaging techniques and biochemical markers of renal injury and dysfunction. Therapies targeting some of the pathological pathways governing the development of RVD have shown promising results in animal models, and a few have moved from bench to clinical research. This review summarizes evolving understanding in chronic ischemic kidney injury.
C1 [Barsom, Samer H.; Glasstetter, Logan M.; Siddiqi, Sarosh; Rajagopalan, Kamalnath Sankaran; Eirin, Alfonso; Lerman, Lilach O.] Mayo Clin, Div Nephrol & Hypertens, 200 First St SW, Rochester, MN 55905 USA.
C3 Mayo Clinic
RP Lerman, LO (corresponding author), Mayo Clin, Div Nephrol & Hypertens, 200 First St SW, Rochester, MN 55905 USA.
EM lerman.lilach@mayo.edu
RI Lerman, Lilach/M-4962-2017; Eirin, Alfonso/N-9873-2013
OI Eirin, Alfonso/0000-0002-3864-9644
FU National Institutes of Health [DK122734, DK120292, AG062104]
FX This work was partly supported by the National Institutes of Health
   [grant numbers DK122734, DK120292, AG062104].
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NR 203
TC 5
Z9 5
U1 0
U2 5
PU PORTLAND PRESS LTD
PI LONDON
PA 1ST FLR, 10 QUEEN STREET PLACE, LONDON, ENGLAND
SN 0143-5221
EI 1470-8736
J9 CLIN SCI
JI Clin. Sci.
PD FEB
PY 2022
VL 136
IS 3
BP 239
EP 256
DI 10.1042/CS20210509
PG 18
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 0N5VC
UT WOS:000782904300002
PM 35129198
DA 2025-06-11
ER

PT J
AU Ikuta, T
   Saito, S
   Tani, H
   Tatefuji, T
   Hashimoto, K
AF Ikuta, Tomoki
   Saito, Shinichiro
   Tani, Hiroko
   Tatefuji, Tomoki
   Hashimoto, Ken
TI Resveratrol derivative-rich melinjo (Gnetum gnemon L.) seed
   extract improves obesity and survival of C57BL/6 mice fed a high-fat
   diet
SO BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
LA English
DT Article
DE melinjo seed extract; resveratrol derivatives; obesity; longevity;
   high-fat diet-fed mice
ID EXTEND LIFE-SPAN; CALORIE RESTRICTION; OXIDATIVE-STRESS; HEALTH;
   ACTIVATORS; PROTECTS; SIRTUINS; DISEASE; GLUCOSE; HUMANS
AB Melinjo (Gnetum gnemon L.) seed extracts (MSEs) are rich in resveratrol dimers (gnemonoside A, C, D, gnetin C), trans-resveratrol, and other resveratrol derivatives. trans-Resveratrol is a widely studied caloric restriction mimetic. In mice fed a high-fat diet (HFD), trans-resveratrol protects against obesity, type 2 diabetes, and premature death. Here, treatment of HFD-fed mice with 2.0% MSE significantly reduced body weight gain (p<0.001), blood insulin (p<0.01), and HOMA-IR (p<0.05) after 8weeks compared with untreated HFD-fed mice. Additionally, 0.2% MSE treatment of HFD-fed mice significantly improved physiological activity (p<0.05) at 18months of age and reduced risk of death due to HFD by 25% (hazard ratio=0.75, p=0.036). These data show that MSE can improve several aspects of metabolic syndrome and survival in mice and may have health benefits as a dietary supplement.
C1 [Ikuta, Tomoki; Saito, Shinichiro; Tani, Hiroko; Tatefuji, Tomoki; Hashimoto, Ken] Yamada Bee Co Inc, Inst Bee Prod & Hlth Sci, Kagamino 7080393, Japan.
RP Saito, S (corresponding author), Yamada Bee Co Inc, Inst Bee Prod & Hlth Sci, 194 Ichiba, Kagamino 7080393, Japan.
EM ss1254@yamada-bee.com
OI Ikuta, Tomoki/0000-0002-4601-2213
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NR 32
TC 22
Z9 24
U1 1
U2 33
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 0916-8451
EI 1347-6947
J9 BIOSCI BIOTECH BIOCH
JI Biosci. Biotechnol. Biochem.
PD DEC 2
PY 2015
VL 79
IS 12
BP 2044
EP 2049
DI 10.1080/09168451.2015.1056510
PG 6
WC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
   Chemistry, Applied; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
   Chemistry; Food Science & Technology
GA CV4FZ
UT WOS:000364223700018
PM 26103448
OA Bronze
DA 2025-06-11
ER

PT J
AU Zhang, S
   Rattanatray, L
   Morrison, JL
   Nicholas, LM
   Lie, S
   McMillen, IC
AF Zhang, Song
   Rattanatray, Leewen
   Morrison, Janna L.
   Nicholas, Lisa M.
   Lie, Shervi
   McMillen, I. Caroline
TI Maternal Obesity and the Early Origins of Childhood Obesity: Weighing Up
   the Benefits and Costs of Maternal Weight Loss in the Periconceptional
   Period for the Offspring
SO EXPERIMENTAL DIABETES RESEARCH
LA English
DT Review
ID GESTATIONAL DIABETES-MELLITUS; ACTIVATED-RECEPTOR-GAMMA; DIET-INDUCED
   OBESITY; BODY-MASS INDEX; METABOLIC SYNDROME; DEVELOPMENTAL ORIGINS;
   EXPERIMENTAL-MODELS; GLUCOSE-TOLERANCE; ADRENAL GROWTH; BIRTH-WEIGHT
AB There is a need to understand the separate or interdependent contributions of maternal prepregnancy BMI, gestational weight gain, glycaemic control, and macronutrient intake on the metabolic outcomes for the offspring. Experimental studies highlight that there may be separate influences of maternal obesity during the periconceptional period and late gestation on the adiposity of the offspring. While a period of dietary restriction in obese mothers may ablate the programming of obesity, it is associated with an activation of the stress axis in the offspring. Thus, maternal obesity may result in epigenetic changes which predict the need for efficient fat storage in postnatal life, while maternal weight loss may lead to epigenetic changes which predict later adversity. Thus, development of dietary interventions for obese mothers during the periconceptional period requires a greater evidence base which allows the effective weighing up of the metabolic benefits and costs for the offspring.
C1 [Zhang, Song; Rattanatray, Leewen; Morrison, Janna L.; Nicholas, Lisa M.; Lie, Shervi; McMillen, I. Caroline] Univ S Australia, Sansom Inst Hlth Res, Sch Pharm & Med Sci, Adelaide, SA 5001, Australia.
C3 University of South Australia
RP McMillen, IC (corresponding author), Univ S Australia, Sansom Inst Hlth Res, Sch Pharm & Med Sci, Adelaide, SA 5001, Australia.
EM caroline.mcmillen@unisa.edu.au
RI McMillen, Isabella/N-5540-2019; Morrison, Janna/B-8308-2009
OI Nicholas, Lisa/0000-0003-1976-1953; Morrison, Janna/0000-0002-8602-8519
FU National Health and Medical Research Council of Australia; Brailsford
   RobertsonTrust; South Australian Cardiovascular Research Network
FX The work reported from this laboratory in this paper was supported by
   funding awarded by the National Health and Medical Research Council of
   Australia (I. C. McMillen, J. L. Morrison) and the Brailsford
   RobertsonTrust (I. C. McMillen). J. L. Morrison is supported by the
   South Australian Cardiovascular Research Network. S. Zhang and L.
   Rattanatray contributed equally to the paper.
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NR 56
TC 56
Z9 64
U1 0
U2 1
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1687-5214
EI 1687-5303
J9 EXP DIABETES RES
JI Exp. Diabetes Res.
PY 2011
AR 585749
DI 10.1155/2011/585749
PG 10
WC Endocrinology & Metabolism; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Research & Experimental Medicine
GA 870PN
UT WOS:000298681500001
PM 22203829
OA Green Published, hybrid, Green Submitted
DA 2025-06-11
ER

PT J
AU Marder, M
   Remmert, C
   Perschel, JA
   Otgonbayar, M
   von Toerne, C
   Hauck, S
   Bushe, J
   Feuchtinger, A
   Sheikh, B
   Moussus, M
   Meier, M
AF Marder, Maren
   Remmert, Caroline
   Perschel, Julius A.
   Otgonbayar, Munkhtur
   von Toerne, Christine
   Hauck, Stefanie
   Bushe, Judith
   Feuchtinger, Annette
   Sheikh, Bilal
   Moussus, Michel
   Meier, Matthias
TI Stem cell-derived vessels-on-chip for cardiovascular disease modeling
SO CELL REPORTS
LA English
DT Article
ID NITRIC-OXIDE SYNTHASE; SHEAR-STRESS; ENRICHMENT ANALYSIS;
   ENDOTHELIAL-CELLS; WEB SERVER; VITRONECTIN; EXPRESSION; GENERATION;
   PLATFORM
AB The metabolic syndrome is accompanied by vascular complications. Human in vitro disease models are hence required to better understand vascular dysfunctions and guide clinical therapies. Here, we engineered an open microfluidic vessel -on -chip platform that integrates human pluripotent stem cell -derived endothelial cells (SC-ECs). The open microfluidic design enables seamless integration with state-of-the-art analytical technologies, including single -cell RNA sequencing, proteomics by mass spectrometry, and high -resolution imaging. Beyond previous systems, we report SC -EC maturation by means of barrier formation, arterial toning, and high nitric oxide synthesis levels under gravity -driven flow. Functionally, we corroborate the hallmarks of early -onset atherosclerosis with low sample volumes and cell numbers under flow conditions by determining proteome and secretome changes in SC-ECs stimulated with oxidized low -density lipoprotein and free fatty acids. More broadly, our organ -on -chip platform enables the modeling of patient -specific human endothelial tissue and has the potential to become a general tool for animal -free vascular research.
C1 [Marder, Maren; Remmert, Caroline; Perschel, Julius A.; Otgonbayar, Munkhtur; Moussus, Michel; Meier, Matthias] Helmholtz Zentrum Munchen, Helmholtz Pioneer Campus, Munich, Germany.
   [von Toerne, Christine; Hauck, Stefanie] Helmholtz Zentrum Munchen, Metabol & Prote Core, Munich, Germany.
   [Bushe, Judith; Feuchtinger, Annette] Helmholtz Munich, Core Facil Pathol & Tissue Analyt, D-85764 Neuherberg, Germany.
   [Sheikh, Bilal] Obes & Vasc Res HI MAG Helmholtz Ctr Munich, Helmholtz Inst Metab, Leipzig, Germany.
   [Sheikh, Bilal] Univ Leipzig, Med Fac, Leipzig, Germany.
   [Meier, Matthias] Univ Leipzig, Ctr Biotechnol & Biomed, Leipzig, Germany.
C3 Helmholtz Association; Helmholtz-Center Munich - German Research Center
   for Environmental Health; Helmholtz Association; Helmholtz-Center Munich
   - German Research Center for Environmental Health; Leipzig University;
   Leipzig University
RP Meier, M (corresponding author), Helmholtz Zentrum Munchen, Helmholtz Pioneer Campus, Munich, Germany.; Meier, M (corresponding author), Univ Leipzig, Ctr Biotechnol & Biomed, Leipzig, Germany.
EM matthias.meier@helmholtz-munich.de
RI Hauck, Stefanie/B-3300-2013; Feuchtinger, Annette/O-4569-2014; von
   Toerne, Christine/B-2233-2013
OI Perschel, Julius A./0009-0004-5756-5958; Sheikh,
   Bilal/0000-0002-1970-6236
FU Helmholtz Pioneer Campus; EIslet project of the BMBF [031L0251]; ERC
   Consolidator Grant [772646]
FX This work was supported by the Helmholtz Pioneer Campus, the eIslet
   project of the BMBF (grant number 031L0251) , and ERC Consolidator Grant
   (number 772646) . We thank Daniel Kokotek, Ioannis Deligiannis, Celia
   Martinez, Inti I.A. de la Rosa Velazquez and G. Eckstein for helping
   with the sample preparation and performing the NovaSeq sequencing. We
   thank Stefan Veit, Revanth Coimbatore Varadarajan, and Che-Wei Chang for
   manufacturing of the chips. Further we thank Thomas Schwarz-Romond for
   critically reading the manuscript.
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NR 73
TC 4
Z9 4
U1 6
U2 16
PU CELL PRESS
PI CAMBRIDGE
PA 50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA
SN 2211-1247
J9 CELL REP
JI Cell Reports
PD APR 23
PY 2024
VL 43
IS 4
AR 114008
DI 10.1016/j.celrep.2024.114008
EA MAR 2024
PG 22
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA PQ0X4
UT WOS:001215439700001
PM 38536819
OA gold
DA 2025-06-11
ER

PT J
AU Wang, XJ
   Xu, MH
   Li, Y
AF Wang, Xiujuan
   Xu, Meihong
   Li, Yong
TI Adipose Tissue Aging and Metabolic Disorder, and the Impact of
   Nutritional Interventions
SO NUTRIENTS
LA English
DT Review
DE adipose tissue; aging; caloric restriction; vitamin; resveratrol
ID VITAMIN-A SUPPLEMENTATION; OXIDATIVE STRESS; VISCERAL FAT; CALORIC
   RESTRICTION; SECRETORY PHENOTYPE; INSULIN-RESISTANCE; BODY-COMPOSITION;
   SKELETAL-MUSCLE; BROWN; OBESITY
AB Adipose tissue is the largest and most active endocrine organ, involved in regulating energy balance, glucose and lipid homeostasis and immune function. Adipose tissue aging processes are associated with brown adipose tissue whitening, white adipose tissue redistribution and ectopic deposition, resulting in an increase in age-related inflammatory factors, which then trigger a variety of metabolic syndromes, including diabetes and hyperlipidemia. Metabolic syndrome, in turn, is associated with increased inflammatory factors, all-cause mortality and cognitive impairment. There is a growing interest in the role of nutritional interventions in adipose tissue aging. Nowadays, research has confirmed that nutritional interventions, involving caloric restriction and the use of vitamins, resveratrol and other active substances, are effective in managing adipose tissue aging's adverse effects, such as obesity. In this review we summarized age-related physiological characteristics of adipose tissue, and focused on what nutritional interventions can do in improving the retrogradation and how they do this.
C1 [Wang, Xiujuan; Xu, Meihong; Li, Yong] Peking Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Beijing 100191, Peoples R China.
C3 Peking University
RP Li, Y (corresponding author), Peking Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Beijing 100191, Peoples R China.
EM 1510306116@pku.edu.cn; xumeihong@bjmu.edu.cn; liyongbmu@163.com
OI Li, Yong/0000-0003-3914-5840; Xu, Meihong/0000-0001-7201-6982
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NR 123
TC 27
Z9 29
U1 1
U2 14
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD AUG
PY 2022
VL 14
IS 15
AR 3134
DI 10.3390/nu14153134
PG 18
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 3S8ID
UT WOS:000839832400001
PM 35956309
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Feraco, A
   Gorini, S
   Armani, A
   Camajani, E
   Rizzo, M
   Caprio, M
AF Feraco, Alessandra
   Gorini, Stefania
   Armani, Andrea
   Camajani, Elisabetta
   Rizzo, Manfredi
   Caprio, Massimiliano
TI Exploring the Role of Skeletal Muscle in Insulin Resistance: Lessons
   from Cultured Cells to Animal Models
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE myofibers; adipose tissue; glucose metabolism; free fatty acids;
   glycemia
ID MYOGENIC REGULATORY FACTORS; SIGNALING PATHWAYS; METABOLIC SYNDROME;
   PROTEIN-DEGRADATION; LIPOPROTEIN-LIPASE; MYOSTATIN KNOCKOUT;
   PHYSICAL-EXERCISE; OXIDATIVE STRESS; ADIPOSE-TISSUE; GLUCOSE-UPTAKE
AB Skeletal muscle is essential to maintain vital functions such as movement, breathing, and thermogenesis, and it is now recognized as an endocrine organ. Muscles release factors named myokines, which can regulate several physiological processes. Moreover, skeletal muscle is particularly important in maintaining body homeostasis, since it is responsible for more than 75% of all insulin-mediated glucose disposal. Alterations of skeletal muscle differentiation and function, with subsequent dysfunctional expression and secretion of myokines, play a key role in the pathogenesis of obesity, type 2 diabetes, and other metabolic diseases, finally leading to cardiometabolic complications. Hence, a deeper understanding of the molecular mechanisms regulating skeletal muscle function related to energy metabolism is critical for novel strategies to treat and prevent insulin resistance and its cardiometabolic complications. This review will be focused on both cellular and animal models currently available for exploring skeletal muscle metabolism and endocrine function.
C1 [Feraco, Alessandra; Gorini, Stefania; Armani, Andrea; Caprio, Massimiliano] IRCCS San Raffaele Roma, Lab Cardiovasc Endocrinol, I-00166 Rome, Italy.
   [Feraco, Alessandra; Armani, Andrea; Camajani, Elisabetta; Caprio, Massimiliano] San Raffaele Roma Open Univ, Dept Human Sci & Promot Qual Life, I-00166 Rome, Italy.
   [Camajani, Elisabetta] Univ Roma La Sapienza, Dept Expt Med, PhD Programme Endocrinol Sci, I-00161 Rome, Italy.
   [Rizzo, Manfredi] Univ Palermo, Sch Med, Promise Dept, I-90127 Palermo, Italy.
C3 IRCCS San Raffaele Pisana; Sapienza University Rome; University of
   Palermo
RP Caprio, M (corresponding author), IRCCS San Raffaele Roma, Lab Cardiovasc Endocrinol, I-00166 Rome, Italy.; Caprio, M (corresponding author), San Raffaele Roma Open Univ, Dept Human Sci & Promot Qual Life, I-00166 Rome, Italy.
EM alessandra.feraco@sanraffaele.it; stefania.gorini@sanraffaele.it;
   andrea.armani@sanraffaele.it; elisabetta.camajani@uniroma1.it;
   manfredi.rizzo@unipa.it; massimiliano.caprio@sanraffaele.it
RI Armani, Andrea/AAC-2071-2022; Camajani, Elisabetta/LRU-6576-2024; RIZZO,
   MANFREDI/GZL-0551-2022; Feraco, Alessandra/K-5920-2016; Caprio,
   Massimiliano/J-3020-2012
OI ARMANI, Andrea/0000-0002-2130-1596; Feraco,
   Alessandra/0000-0002-7074-0480; RIZZO, Manfredi/0000-0002-9549-8504; ,
   Elisabetta Camajani/0000-0002-1866-8223; Caprio,
   Massimiliano/0000-0003-0722-7163
FU Italian Ministry of Health; MIUR (Progetti di Ricerca di Interesse
   Nazionale 2017) [2017A5TXC3]
FX This study was supported by the Italian Ministry of Health (Ricerca
   Corrente), and by MIUR (Progetti di Ricerca di Interesse Nazionale
   2017-project code 2017A5TXC3-to MC, Work Package Leader). Figures
   generation has been performed by using BioRender program.
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PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD SEP
PY 2021
VL 22
IS 17
AR 9327
DI 10.3390/ijms22179327
PG 17
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA UO0UW
UT WOS:000694420400001
PM 34502235
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Matacchione, G
   Gurau, F
   Baldoni, S
   Prattichizzo, F
   Silvestrini, A
   Giuliani, A
   Pugnaloni, A
   Espinosa, E
   Amenta, F
   Bonafè, M
   Procopio, AD
   Rippo, MR
   Olivieri, F
   Sabbatinelli, J
AF Matacchione, Giulia
   Gurau, Felicia
   Baldoni, Simone
   Prattichizzo, Francesco
   Silvestrini, Andrea
   Giuliani, Angelica
   Pugnaloni, Armanda
   Espinosa, Emma
   Amenta, Francesco
   Bonafe, Massimiliano
   Procopio, Antonio Domenico
   Rippo, Maria Rita
   Olivieri, Fabiola
   Sabbatinelli, Jacopo
TI Pleiotropic effects of polyphenols on glucose and lipid metabolism:
   Focus on clinical trials
SO AGEING RESEARCH REVIEWS
LA English
DT Review
DE Polyphenols; Type 2 diabetes; Dyslipidemia; Metabolic syndrome;
   Nutraceutical
ID DIET-INDUCED OBESITY; GUT MICROBIOTA COMPOSITION;
   LOW-DENSITY-LIPOPROTEIN; GREEN TEA; INSULIN SENSITIVITY; IN-VITRO;
   OXIDATIVE STRESS; AMELIORATES HYPERGLYCEMIA; HEPATIC GLUCONEOGENESIS;
   CHOLESTEROL EFFLUX
AB Epidemiological evidence from observational studies suggests that dietary polyphenols (PPs) - phytochemicals found in a variety of plant-based foods - can reduce the risk of developing type 2 diabetes mellitus (T2DM). Clinical trials have also indicated that PPs may help manage the two key features of T2DM, hyperglycemia and dyslipidemia. Since the incidence of T2DM is dramatically increasing worldwide, identifying food-based approaches that can reduce the risk of developing it and help manage its main risk factors in early-stage disease has clinical and socioeconomic relevance.
   After a brief overview of current epidemiological data on the incidence of T2DM in individuals consuming PP-rich diets, we review the evidence from clinical trials investigating PP-enriched foods and/or PP-based nutraceutical compounds, report their main results, and highlight the knowledge gaps that should be bridged to enhance our understanding of the role of PPs in T2DM development and management.
C1 [Matacchione, Giulia; Gurau, Felicia; Silvestrini, Andrea; Giuliani, Angelica; Pugnaloni, Armanda; Espinosa, Emma; Procopio, Antonio Domenico; Rippo, Maria Rita; Olivieri, Fabiola; Sabbatinelli, Jacopo] Univ Politecn Marche, DISCLIMO, Dept Clin & Mol Sci, Ancona, Italy.
   [Baldoni, Simone; Amenta, Francesco] Univ Camerino, Sch Med & Hlth Prod Sci, Camerino, Italy.
   [Prattichizzo, Francesco] IRCCS MultiMed, Milan, Italy.
   [Bonafe, Massimiliano] Univ Bologna, Dept Expt Diagnost & Specialty Med, Alma Mater Studiorum, Bologna, Italy.
   [Procopio, Antonio Domenico; Olivieri, Fabiola] IRCCS, INRCA, Ctr Clin Pathol & Innovat Therapy, Ancona, Italy.
C3 Marche Polytechnic University; University of Camerino; IRCCS
   Multimedica; University of Bologna; IRCCS INRCA
RP Olivieri, F (corresponding author), Univ Politecn Marche, Dept Clin & Mol Sci, Via Tronto 10-A, I-60126 Ancona, Italy.
EM f.olivieri@univpm.it
RI Giuliani, Angelica/AAB-9024-2019; Procopio, Antonio/AAB-2451-2021;
   Bonafe, Massimiliano/K-5416-2016; Matacchione, Giulia/AAC-2682-2019;
   Prattichizzo, Francesco/J-3046-2018; Sabbatinelli, Jacopo/U-1851-2018;
   Olivieri, Fabiola/K-6465-2016
OI RIPPO, Maria Rita/0000-0003-3024-3495; Prattichizzo,
   Francesco/0000-0002-2959-2658; Sabbatinelli, Jacopo/0000-0001-9947-6778;
   Silvestrini, Andrea/0000-0002-3586-6635; Olivieri,
   Fabiola/0000-0002-9606-1144; Procopio, Antonio/0000-0001-6897-8724;
   Giuliani, Angelica/0000-0002-8477-8519
FU UNIVPM; Regione Marche (POR MARCHE FESR 2014-2020) [10439]; EUREKA grant
   - Regione Marche; University of Camerino; Namirial SpA; Italian Ministry
   of Health
FX This study was supported by grants from UNIVPM to FO and from Regione
   Marche (POR MARCHE FESR 2014-2020, project PrInTAGE 10439) to FO and
   MRR. Dr. Simone Baldoni is the recipient of a EUREKA grant supported by
   Regione Marche, the University of Camerino and Namirial SpA. This work
   has been also supported by the Italian Ministry of Health (Ricerca
   Corrente to IRCCS MultiMedica).
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NR 112
TC 36
Z9 36
U1 2
U2 42
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 1568-1637
EI 1872-9649
J9 AGEING RES REV
JI Ageing Res. Rev.
PD AUG
PY 2020
VL 61
AR 101074
DI 10.1016/j.arr.2020.101074
PG 11
WC Cell Biology; Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Geriatrics & Gerontology
GA LY7MX
UT WOS:000540712600007
PM 32335301
DA 2025-06-11
ER

PT J
AU Meydanli, EG
   Gumusel, A
   Ozkan, S
   Tanriverdi, G
   Balci, MBC
   Is, SD
   Hazar, AI
   Uysal, M
   Bekpinar, S
AF Meydanli, Elif Guzel
   Gumusel, Asli
   Ozkan, Serbay
   Tanriverdi, Gamze
   Balci, M. B. Can
   Is, Seval Develi
   Hazar, A. Ismet
   Uysal, Mujdat
   Bekpinar, Seldag
TI Effects of resveratrol on high-fructose-induced testis injury in rats
SO ULTRASTRUCTURAL PATHOLOGY
LA English
DT Article
DE Apoptosis; electron microscopy; high-fructose diet; resveratrol; testis
ID INHIBIN-B LEVELS; METABOLIC SYNDROME; OXIDATIVE STRESS;
   INSULIN-RESISTANCE; SERTOLI-CELLS; HIGH-CALORIE; MEN; OBESITY; MICE;
   SPERMATOGENESIS
AB This study investigated whether a high-fructose (HFr) diet changes the morphology of seminiferous tubules (ST) in rats and resveratrol (RES) has a possible restoring effect in this sense. Fructose (30%; w/v) was administered to rats alone or together with RES (50 mg/L) in drinking water for 8 weeks. In the HFr group, destruction of the germinal epithelium led to the detection of immature germ cells in the lumen. HFr diet gave rise to a decrease in the ST diameters (p < 0.05), Johnsen's tubular biopsy score values (p < 0.001), and an increase in the apoptotic index (p < 0.05). Ultrastructurally, HFr feeding increased lipid accumulation (p < 0.01), mitochondrial damage, and acrosomal abnormalities in spermatogenic cells. Treatment of HFr-fed rats with RES improved the reduced ST diameters and overall general histological and ultrastructural abnormalities of the STs, but did not change the increased apoptotic index.
C1 [Meydanli, Elif Guzel; Gumusel, Asli; Ozkan, Serbay; Tanriverdi, Gamze] Istanbul Univ, Cerrahpasa Med Fac, Dept Histol & Embryol, TR-34098 Istanbul, Turkey.
   [Balci, M. B. Can; Hazar, A. Ismet] GOP Taksim Training & Res Hosp, Dept Urol, Istanbul, Turkey.
   [Is, Seval Develi; Uysal, Mujdat; Bekpinar, Seldag] Istanbul Univ, Istanbul Fac Med, Dept Biochem, Istanbul, Turkey.
C3 Istanbul University - Cerrahpasa; Istanbul University; Istanbul
   Gaziosmanpasa Taksim Training & Research Hospital; Istanbul University
RP Meydanli, EG (corresponding author), Istanbul Univ, Cerrahpasa Med Fac, Dept Histol & Embryol, TR-34098 Istanbul, Turkey.
EM elifguzelctf@yahoo.com
RI Bekpinar, Seldag/AAD-9066-2020; Özkan, Serbay/D-6812-2019; Tanriverdi,
   Gamze/Q-2476-2015; BALCI, Mustafa Bahadir Can/V-7913-2019; Guzel
   Meydanli, Emine Elif/D-6668-2019
OI Ozkan, Serbay/0000-0001-7854-4735; Tanriverdi,
   Gamze/0000-0002-8646-0336; BALCI, Mustafa Bahadir
   Can/0000-0003-0395-1154; Guzel Meydanli, Emine Elif/0000-0001-9072-3322
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Z9 22
U1 0
U2 5
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 0191-3123
EI 1521-0758
J9 ULTRASTRUCT PATHOL
JI Ultrastruct. Pathol.
PY 2018
VL 42
IS 1
BP 65
EP 73
DI 10.1080/01913123.2017.1397075
PG 9
WC Microscopy; Pathology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Microscopy; Pathology
GA GB7OF
UT WOS:000429263200009
PM 29192848
DA 2025-06-11
ER

PT J
AU Angelopoulou, R
   Lavranos, G
   Manolakou, P
   Katsiki, E
AF Angelopoulou, Roxani
   Lavranos, Giagkos
   Manolakou, Panagiota
   Katsiki, Evangelia
TI Fertility in the Aging Male: Molecular Pathways in the Anthropology of
   Aging
SO COLLEGIUM ANTROPOLOGICUM
LA English
DT Review
DE androgens; aging; reproduction; infertility; male; sex
ID LATE-ONSET HYPOGONADISM; SPERM DNA-DAMAGE; MIDDLE-AGED MEN; TESTOSTERONE
   UNDECANOATE; OXIDATIVE STRESS; SEXUAL DYSFUNCTION; METABOLIC SYNDROME;
   Y-CHROMOSOME; ELDERLY-MEN; APOPTOSIS
AB The aging process is a normal stage in development characterized by the gradual deterioration of all life functions. As far as reproduction is concerned, aging is characterized by a significant limitation of fertility in both sexes. This process is, at least partially, attributed to the action (or loss of action) of sex steroids, coinciding with low activity of the pituitary-gonad axis. From an anthropological point of view, the study of reproductive aging is a unique opportunity to investigate various environmental and endogenous factors influencing sexual behavior and, thus, playing a significant role in human biology. Various techniques are now widely available to allow the detailed examination of reproductive hazards using only minor samples of genetic material. These methods are highly sensitive and specific and allow the characterization of distortions at subcellular and even molecular level. This short review briefly summarizes the current understanding of reproductive aging, as well as its potential clinical and anthropological impact.
C1 [Angelopoulou, Roxani; Lavranos, Giagkos; Manolakou, Panagiota; Katsiki, Evangelia] Univ Athens, Sch Med, Dept Histol & Embryol, Athens 11527, Greece.
C3 National & Kapodistrian University of Athens; Athens Medical School
RP Lavranos, G (corresponding author), Univ Athens, Sch Med, Dept Histol & Embryol, 75 M Assias St, Athens 11527, Greece.
EM glavran@med.uoa.gr
OI Manolakou, Panagiota/0000-0002-1125-8758
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NR 61
TC 4
Z9 4
U1 0
U2 4
PU COLLEGIUM ANTROPOLOGICUM
PI ZAGREB
PA INST ANTHROPOLOGICAL RESEARCH, GAJEVA 32, PO BOX 290, HR-10000 ZAGREB,
   CROATIA
SN 0350-6134
J9 COLLEGIUM ANTROPOL
JI Coll. Anthropol.
PD JUN
PY 2013
VL 37
IS 2
BP 657
EP 661
PG 5
WC Anthropology
WE Social Science Citation Index (SSCI)
SC Anthropology
GA 196TW
UT WOS:000322801300051
PM 23941021
DA 2025-06-11
ER

PT J
AU Zhu, CS
   Xiong, ZJ
   Zheng, ZD
   Chen, YM
   Qian, XX
   Chen, XH
AF Zhu, Cansheng
   Xiong, Zhaojun
   Zheng, Zhenda
   Chen, Yanming
   Qian, Xiaoxian
   Chen, Xiaohong
TI Association of Serum Gamma-Glutamyltransferase With Arterial Stiffness
   in Established Coronary Artery Disease
SO ANGIOLOGY
LA English
DT Article
DE brachial-ankle pulse wave velocity; arterial stiffness; coronary artery
   disease; gamma-glutamyltransferase
ID PULSE-WAVE VELOCITY; METABOLIC SYNDROME; CARDIOVASCULAR-DISEASE;
   RISK-FACTOR; HYPERTENSIVE PATIENTS; CLINICAL RELEVANCE; OXIDATIVE
   STRESS; ATHEROSCLEROSIS; TRANSPEPTIDASE; HEART
AB Serum gamma-glutamyltransferase (GGT) has been reported to predict vascular risk. We enrolled 978 patients (507 men and 471 women) with established coronary artery disease (CAD). The GGT, brachial-ankle pulse wave velocity ([baPWV] to assess arterial stiffness), and conventional risk factors were evaluated. The means of baPWV tend to increase in both genders according to GGT tertiles. Body mass index, GGT, logarithmical (systolic blood pressure [LnSBP]), uric acid (UA), total bilirubin, Ln (cholinesterase), and Ln (total cholesterol) were correlated with baPWV in men in a multivariate model. However, only GGT, LnSBP, UA, and Ln (high-density lipoprotein cholesterol) were correlated with baPWV in women. The GGT was a significant determinant for increased baPWV both in men (beta - 0.017; P < .001) and in women (beta - 0.015; P < .001). In conclusion, GGT was independently associated with increased arterial stiffness both in men and in women with established CAD.
C1 [Zhu, Cansheng; Chen, Xiaohong] Sun Yat Sen Univ, Affiliated Hosp 3, Dept Neurol, Guangzhou 510630, Guangdong, Peoples R China.
   [Xiong, Zhaojun; Zheng, Zhenda; Qian, Xiaoxian] Sun Yat Sen Univ, Affiliated Hosp 3, Dept Cardiovasc Dis, Guangzhou 510630, Guangdong, Peoples R China.
   [Chen, Yanming] Sun Yat Sen Univ, Affiliated Hosp 3, Dept Endocrinol & Metab, Guangzhou 510630, Guangdong, Peoples R China.
C3 Sun Yat Sen University; Sun Yat Sen University; Sun Yat Sen University
RP Chen, XH (corresponding author), Sun Yat Sen Univ, Affiliated Hosp 3, Dept Neurol, Guangzhou 510630, Guangdong, Peoples R China.
EM xhongchen@yahoo.cn
RI zheng, ziwen/LFR-7449-2024; Wu, Zhenhua/M-9894-2017
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NR 35
TC 15
Z9 16
U1 0
U2 6
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0003-3197
J9 ANGIOLOGY
JI Angiology
PD JAN
PY 2013
VL 64
IS 1
BP 15
EP 20
DI 10.1177/0003319712459799
PG 6
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 049TU
UT WOS:000312007100003
PM 23000601
DA 2025-06-11
ER

PT J
AU Vigueras-Villaseñor, RM
   Rojas-Castañeda, JC
   Chávez-Saldaña, M
   Gutiérrez-Pérez, O
   García-Cruz, ME
   Cuevas-Alpuche, O
   Reyes-Romero, MM
   Zambrano, E
AF Maria Vigueras-Villasenor, Rosa
   Cesar Rojas-Castaneda, Julio
   Chavez-Saldana, Margarita
   Gutierrez-Perez, Oscar
   Edna Garcia-Cruz, Mercedes
   Cuevas-Alpuche, Osvaldo
   Manuel Reyes-Romero, Marcos
   Zambrano, Elena
TI Alterations in the spermatic function generated by obesity in rats
SO ACTA HISTOCHEMICA
LA English
DT Article
DE Obesity; Fertility; Epididymis; Rat; Oxidative stress; Testis
ID HORMONE-BINDING-GLOBULIN; BODY-MASS INDEX; ERECTILE DYSFUNCTION;
   INSULIN-RESISTANCE; TOTAL TESTOSTERONE; METABOLIC SYNDROME;
   ENDOTHELIAL-CELLS; MALE-INFERTILITY; SEMEN QUALITY; MEN
AB In order to assess the effect of obesity on epididymal and germinal epithelia in control rats and obese rats induced by a high fat diet, we evaluated the epididymal and testicular morphologies, lipid peroxidation in the epididymis, leptin serum levels, steroid hormones, insulin, cholesterol, triglycerides, glycemia and some spermatobioscopic parameters. No significant difference was observed in the levels of insulin, glucose, cholesterol and triglycerides between the two groups. Nonetheless, in the obese rats, circulating leptin and estradiol levels showed a significant increase and there was a decline in the testosterone levels. The same group showed an increase in the lipid peroxidation of the epididymis and reduced spermatobioscopic parameters. The heads of the epididymis showed morphological differences in obese rats. No significant difference was observed between the testes of both groups. There is a clear evidence of an effect on sperm in obese rats and this seems to occur in the epididymis. (C) 2010 Elsevier GmbH. All rights reserved.
C1 [Maria Vigueras-Villasenor, Rosa; Cesar Rojas-Castaneda, Julio; Chavez-Saldana, Margarita; Gutierrez-Perez, Oscar; Edna Garcia-Cruz, Mercedes; Cuevas-Alpuche, Osvaldo; Manuel Reyes-Romero, Marcos] Inst Nacl Pediat, Subdirecc Med Expt, Mexico City 04530, DF, Mexico.
   [Maria Vigueras-Villasenor, Rosa] Univ Nacl Autonoma Mexico, Fac Med Vet & Zootecnia, Mexico City, DF, Mexico.
   [Zambrano, Elena] Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Mexico City, DF, Mexico.
C3 Universidad Nacional Autonoma de Mexico; Instituto Nacional de Ciencias
   Medicas y Nutricion Salvador Zubiran - Mexico
RP Vigueras-Villaseñor, RM (corresponding author), Inst Nacl Pediat, Subdirecc Med Expt, Av Insurgentes Sur 3700-C, Mexico City 04530, DF, Mexico.
EM marcoviv@servidor.unam.mx; rocajc1@yahoo.com.mx;
   mchavez_s2003@yahoo.com.mx; koala630816@yahoo.com.mx;
   ednagcmeg@gmail.com; cuevasuro@yahoo.com.mx; marcosreyes.rom@gmail.com;
   zamgon@servidor.unam.mx
RI Chávez, Margarita/AAT-5804-2021; Gutiérrez-Pérez, Oscar/B-7663-2012
OI GARCIA, EDNA/0000-0002-8708-4184; Gutierrez-Perez,
   Oscar/0000-0002-4971-9142; Zambrano, Elena/0000-0002-0362-9117
FU CONACyT [53057]
FX We are grateful to Pedro Medina Granados. Edgar Daniel Cervantes Arias
   and Octavio Alberto Ferreyra Cruz for technical assistance. This work
   was supported by 53057 CONACyT grants.
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NR 59
TC 65
Z9 69
U1 1
U2 19
PU ELSEVIER GMBH, URBAN & FISCHER VERLAG
PI JENA
PA OFFICE JENA, P O BOX 100537, 07705 JENA, GERMANY
SN 0065-1281
EI 1618-0372
J9 ACTA HISTOCHEM
JI Acta Histochem.
PY 2011
VL 113
IS 2
BP 214
EP 220
DI 10.1016/j.acthis.2009.10.004
PG 7
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA 741TW
UT WOS:000288888900018
PM 20149418
DA 2025-06-11
ER

PT J
AU Malak, A
   Aslan, E
AF Malak, Arzu
   Aslan, Ergul
TI Lower Urinary Tract Symptoms and Quality of Life in Obese Women: A
   Qualitative Study
SO INTERNATIONAL JOURNAL OF UROLOGICAL NURSING
LA English
DT Article
DE lower urinary tract symptoms; obesity; qualitative; quality of life;
   women
ID PELVIC FLOOR DISORDERS; OVERACTIVE BLADDER; METABOLIC SYNDROME; SEXUAL
   FUNCTION; RISK-FACTORS; INCONTINENCE; PREVALENCE; STRESS; INTERVENTIONS;
   ASSOCIATION
AB This study was conducted to determine lower urinary tract symptoms (LUTS) and their impact on the quality of life in obese women with LUTS. This study was conducted using a qualitative method at a university hospital. In-depth interviews were conducted with 30 obese women who had LUTS and no chronic illnesses using a semi-structured interview form. The interviews were evaluated through content analysis, and themes were identified and findings were interpreted. Qualitative analysis revealed that LUTS significantly affected women's lives, with complaints increasing as the degree of obesity increased. Most women reported searching for a restroom when going out, being unable to perform religious practices such as prayer, and experiencing negative effects on their sexual lives. Most women indicated that the causes of urinary tract symptoms were pregnancy/birth, excess weight and ageing. In conclusion, it was observed that obesity causes LUTS in women and negatively affects their quality of life.
C1 [Malak, Arzu] Tekirdag Namik Kemal Univ, Fac Hlth Sci, Nursing Dept, Tekirdag, Turkiye.
   [Aslan, Ergul] Istanbul Univ Cerrahpasa, Florence Nightingale Nursing Fac, Istanbul, Turkiye.
C3 Namik Kemal University; Istanbul University - Cerrahpasa
RP Malak, A (corresponding author), Tekirdag Namik Kemal Univ, Fac Hlth Sci, Nursing Dept, Tekirdag, Turkiye.
EM amalak@nku.edu.tr
RI ASLAN, ERGUL/W-3538-2017; malak, arzu/ABA-1600-2020
CR A Healthy Lifestyle, 2010, WHO Recommendations. Body Mass Index
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NR 36
TC 0
Z9 0
U1 1
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1749-7701
EI 1749-771X
J9 INT J UROL NURS
JI Int. J. Urol. Nurs.
PD MAR
PY 2025
VL 19
IS 1
AR e70003
DI 10.1111/ijun.70003
PG 9
WC Nursing; Urology & Nephrology
WE Emerging Sources Citation Index (ESCI)
SC Nursing; Urology & Nephrology
GA W5G0L
UT WOS:001418844900001
OA hybrid
DA 2025-06-11
ER

PT J
AU Isola, G
   Santonocito, S
   Lupi, SM
   Polizzi, A
   Sclafani, R
   Patini, R
   Marchetti, E
AF Isola, Gaetano
   Santonocito, Simona
   Lupi, Saturnino Marco
   Polizzi, Alessandro
   Sclafani, Rossana
   Patini, Romeo
   Marchetti, Enrico
TI Periodontal Health and Disease in the Context of Systemic Diseases
SO MEDIATORS OF INFLAMMATION
LA English
DT Review
ID C-REACTIVE PROTEIN; ORAL-CANCER; FUSOBACTERIUM-NUCLEATUM;
   CARDIOVASCULAR-DISEASE; ALZHEIMERS-DISEASE; METABOLIC SYNDROME;
   OXIDATIVE STRESS; BREAST-CANCER; DIABETIC-PATIENTS; GLYCEMIC CONTROL
AB During recent years, considerable progress has been made in understanding the etiopathogenesis of periodontitis in its various forms and their interactions with the host. Furthermore, a number of reports have highlighted the importance of oral health and disease in systemic conditions, especially cardiovascular diseases and diabetes. In this regard, research has attempted to explain the role of periodontitis in promoting alteration in distant sites and organs. Recently, DNA sequencing studies have revealed how oral infections can occur in distant sites such as the colon, reproductive tissues, metabolic diseases, and atheromas. The objective of this review is to describe and update the emerging evidence and knowledge regarding the association between periodontitis and systemic disease and to analyse the evidence that has reported periodontitis as a risk factor for the development of various forms of systemic diseases in order to provide a better understanding of the possible shared etiopathogenetic pathways between periodontitis and the different forms of systemic diseases.
C1 [Isola, Gaetano; Santonocito, Simona; Polizzi, Alessandro; Sclafani, Rossana] Univ Catania, Sch Dent, Dept Gen Surg & Surg Med Specialties, Catania, Italy.
   [Lupi, Saturnino Marco] Univ Pavia, Dept Clin Surg Diagnost & Paediat Sci, Pavia, Italy.
   [Patini, Romeo] Univ Cattolica Sacro Cuore, Fdn Policlin Univ Agostino Gemelli, Inst Dent & Maxillofacial Surg, Rome, Italy.
   [Marchetti, Enrico] Univ Aquila, Dept Life Hlth & Environm Sci, Laquila, Italy.
C3 University of Catania; University of Pavia; Catholic University of the
   Sacred Heart; IRCCS Policlinico Gemelli; University of L'Aquila
RP Isola, G (corresponding author), Univ Catania, Sch Dent, Dept Gen Surg & Surg Med Specialties, Catania, Italy.
EM gaetano.isola@unict.it; simona.santonocito93@gmail.com;
   saturninomarco.lupi@unipv.it; alexpoli345@gmail.com;
   sclafanirossana@yahoo.it; romeo.patini@unicatt.it;
   enrico.marchetti@univaq.it
RI Patini, Romeo/AFU-5391-2022; MARCHETTI, ENRICO/AAG-7883-2019; Lupi,
   Saturnino Marco/ABE-7215-2021; Santonocito, Simona/ISB-1049-2023; Isola,
   Gaetano/H-2878-2019; Polizzi, Alessandro/AAE-3790-2021
OI Isola, Gaetano/0000-0003-4267-6992; Patini, Romeo/0000-0001-7358-8763;
   MARCHETTI, ENRICO/0000-0001-6461-7876; Santonocito,
   Simona/0000-0003-1020-4341; Polizzi, Alessandro/0000-0001-6717-8899
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NR 171
TC 47
Z9 48
U1 0
U2 15
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0962-9351
EI 1466-1861
J9 MEDIAT INFLAMM
JI Mediat. Inflamm.
PD MAY 13
PY 2023
VL 2023
AR 9720947
DI 10.1155/2023/9720947
PG 19
WC Cell Biology; Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Immunology
GA G6RH6
UT WOS:000990402200001
PM 37214190
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Torres-Fuentes, C
   Suárez, M
   Aragonès, G
   Mulero, M
   Avila-Román, J
   Arola-Arnal, A
   Salvadó, MJ
   Arola, L
   Bravo, FI
   Muguerza, B
AF Torres-Fuentes, Cristina
   Suarez, Manuel
   Aragones, Gerard
   Mulero, Miquel
   Avila-Roman, Javier
   Arola-Arnal, Anna
   Josepa Salvado, Maria
   Arola, Lluis
   Isabel Bravo, Francisca
   Muguerza, Begona
TI Cardioprotective Properties of Phenolic Compounds: A Role for Biological
   Rhythms
SO MOLECULAR NUTRITION & FOOD RESEARCH
LA English
DT Review
DE cardiovascular diseases; circadian rhythms; endothelial function;
   oxidative stress; polyphenols
ID NITRIC-OXIDE SYNTHASE; GRAPE SEED PROANTHOCYANIDINS; OXIDATION-SENSITIVE
   GENES; POMEGRANATE FRUIT EXTRACT; HIGH-FAT DIET; CIRCADIAN CLOCK;
   BLOOD-PRESSURE; RED WINE; INSULIN-RESISTANCE; METABOLIC SYNDROME
AB Cardiovascular diseases (CVD) are the leading cause of deaths worldwide and their prevalence is continuously increasing. Available treatments may present several side effects and therefore the development of new safer therapeutics is of interest. Phenolic compounds have shown several cardioprotective properties helpful in reducing different CVD risk factors such as inflammation, elevated blood pressure, hyperlipidemia, or endothelial dysfunction. These factors are significantly influenced by biological rhythms which are in fact emerging as key modulators of important metabolic and physiological processes. Thus, increased events of CVD have been observed under circadian rhythm disruption or in winter versus other seasons. These rhythms can also affect the functionality of phenolic compounds. Indeed, different effects have been observed depending on the administration time or under different photoperiods. Therefore, in this review the focus will be on the potential of phenolic compounds as therapeutics to prevent CVD via biological rhythm modulation.
C1 [Torres-Fuentes, Cristina; Suarez, Manuel; Aragones, Gerard; Mulero, Miquel; Avila-Roman, Javier; Arola-Arnal, Anna; Josepa Salvado, Maria; Arola, Lluis; Isabel Bravo, Francisca; Muguerza, Begona] Univ Rovira & Virgili, Dept Bioquim & Biotecnol, Nutrigen Res Grp, Tarragona 43007, Spain.
C3 Universitat Rovira i Virgili
RP Bravo, FI (corresponding author), Univ Rovira & Virgili, Dept Bioquim & Biotecnol, Nutrigen Res Grp, Tarragona 43007, Spain.
EM franciscaisabel.bravo@urv.cat
RI Muguerza, Begoña/AAT-3544-2021; Bravo, Francisca/L-4409-2019;
   Torres-Fuentes, Cristina/J-5551-2019; Muguerza, Begona/C-6704-2015;
   SALVADO, JOSEPA/B-6062-2015; Arola, Lluis/C-6074-2011; Mulero,
   Miquel/L-4672-2014; Arola-Arnal, Anna/C-2087-2015; Aragones,
   Gerard/F-9673-2016; Suarez Recio, Manuel/F-5039-2016
OI Muguerza, Begona/0000-0001-7384-8588; SALVADO,
   JOSEPA/0000-0003-3883-3326; Arola, Lluis/0000-0003-2767-1974; Mulero,
   Miquel/0000-0003-2545-2065; Arola-Arnal, Anna/0000-0001-6529-1345;
   Aragones, Gerard/0000-0001-8657-5726; Bravo, Francisca
   Isabel/0000-0002-6468-3088; Suarez Recio, Manuel/0000-0003-0122-8253;
   TORRES-FUENTES, CRISTINA/0000-0002-2917-6910
FU Ministerio de Economia y Competitividad [RETOS COLABORACION:
   RTC-2017-6044-2]; European Regional Development Fund (FEDER); Ministerio
   de Ciencia e Innovacion [PID2020-113739RB-I00]; Agencia Estatal de
   Investigacion(AEI); FEDER
FX C.T.-F. and M.S. contributed equally to this work. G.A, M.M, A.A-A, and
   F.I.B are Serra Hunter Fellows. This work has been supported by Grant
   numbers: RETOS COLABORACION: RTC-2017-6044-2 from Ministerio de Economia
   y Competitividad and European Regional Development Fund (FEDER) and
   PID2020-113739RB-I00 from the Ministerio de Ciencia e Innovacion, the
   Agencia Estatal de Investigacion(AEI) and FEDER.
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NR 186
TC 21
Z9 21
U1 3
U2 28
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1613-4125
EI 1613-4133
J9 MOL NUTR FOOD RES
JI Mol. Nutr. Food Res.
PD NOV
PY 2022
VL 66
IS 21
SI SI
AR 2100990
DI 10.1002/mnfr.202100990
EA MAR 2022
PG 11
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA 5X5UO
UT WOS:000773566300001
PM 35279936
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Xie, YY
   Liu, L
AF Xie, Yingying
   Liu, Ling
TI Role of Chemerin/ChemR23 axis as an emerging therapeutic perspective on
   obesity-related vascular dysfunction
SO JOURNAL OF TRANSLATIONAL MEDICINE
LA English
DT Review
DE Chemerin; ChemR23; White adipose tissue; Adipokine; Obesity; Vascular
   dysfunction
ID SMOOTH-MUSCLE-CELL; AORTIC-ANEURYSM FORMATION; ADIPOSE-TISSUE; OXIDATIVE
   STRESS; SERUM CHEMERIN; RESOLVIN E1; ENDOTHELIAL DYSFUNCTION;
   CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; PULMONARY-ARTERY
AB Sufficient epidemiological investigations demonstrate that there is a close correlation between obesity and vascular dysfunction. Nevertheless, specific mechanisms underlying this link remain currently unclear. Given the crucial and decisive role of vascular dysfunction in multitudinous diseases, various hypotheses had been proposed and numerous experiments were being carried out. One recognized view is that increased adipokine secretion following the expanded mass of white adipose tissue due to obesity contributes to the regulation of vascular function. Chemerin, as a neo-adipokine, whose systemic level is elevated in obesity, is believed as a regulator of adipogenesis, inflammation, and vascular dysfunction via binding its cell surface receptor, chemR23. Hence, this review aims to focus on the up-to-date proof on chemerin/chemR23 axis-relevant signaling pathways, emphasize the multifarious impacts of chemerin/chemR23 axis on vascular function regulation, raise certain unsettled questions to inspire further investigations, and explore the therapeutic possibilities targeting chemerin/chemR23.
C1 [Xie, Yingying; Liu, Ling] Cent South Univ, Xiangya Hosp 2, Dept Cardiovasc Med, Changsha, Peoples R China.
   [Xie, Yingying; Liu, Ling] Cent South Univ, Res Inst Blood Lipid & Atherosclerosis, Changsha, Peoples R China.
   [Xie, Yingying; Liu, Ling] Modern Cardiovasc Dis Clin Technol Res Ctr Hunan, Changsha, Peoples R China.
   [Xie, Yingying; Liu, Ling] Cardiovasc Dis Res Ctr Hunan Prov, Changsha, Peoples R China.
C3 Central South University; Central South University
RP Liu, L (corresponding author), Cent South Univ, Xiangya Hosp 2, Dept Cardiovasc Med, Changsha, Peoples R China.
EM feliuling@csu.edu.cn
FU project of Health Commission of Hunan [202203012938]
FX This study was supported by the project of Health Commission of Hunan,
   NO. 202203012938.
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NR 151
TC 20
Z9 21
U1 2
U2 14
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
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J9 J TRANSL MED
JI J. Transl. Med.
PD MAR 22
PY 2022
VL 20
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PG 15
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA ZX9GK
UT WOS:000772201100003
PM 35317838
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Zhang, X
   Xin, YP
   Chen, ZG
   Xia, YZ
   Xun, LY
   Liu, HW
AF Zhang, Xi
   Xin, Yuping
   Chen, Zhigang
   Xia, Yongzhen
   Xun, Luying
   Liu, Huaiwei
TI Sulfide-quinone oxidoreductase is required for cysteine synthesis and
   indispensable to mitochondrial health
SO REDOX BIOLOGY
LA English
DT Article
DE Mitochondria health; Reactive sulfur species; Sqr; Cysteine
   biosynthesis; Hydrogen sulfide; Schizosaccharomyces pombe
ID S-SULFOCYSTEINE SYNTHASE; HYDROGEN-SULFIDE; CHEMICAL BIOLOGY;
   SCHIZOSACCHAROMYCES-POMBE; SULFUR; PERSULFIDES; CHEMISTRY; OXIDATION;
   STRESS; MODEL
AB Mitochondrial dysfunction is related to common age-related disorders, including neurodegenerative diseases, metabolic syndrome, and carcinogenesis. Therefore, maintaining the functionality and integrity of mitochondria is important for human health. Herein, we found that sulfide:quinone oxidoreductase (Sqr), which oxidizes hydrogen sulfide to reactive sulfur species (RSS), was indispensable to mitochondria health in the eukaryotic model microorganism Schizosaccharomyces pombe. Sqr knock-out led to morphological changes and functional deficiencies of mitochondria and apoptosis in S. pombe. The Sqr knock-out strain displayed the same phenotypes as the cysteine-synthesis-deficient strain, and cysteine addition complemented the effects caused by Sqr knockout. In S. pombe, Sqr was the main RSS producer in mitochondria, and RSS instead of H2S was used by cysteine synthase to synthesize cysteine. This finding rewrites the cysteine biosynthesis route in S. pombe and may also in other eukaryotes and prokaryotes, and highlights the importance of cysteine and RSS in maintaining mitochondrial health.
C1 [Zhang, Xi; Xin, Yuping; Chen, Zhigang; Xia, Yongzhen; Xun, Luying; Liu, Huaiwei] Shandong Univ, State Key Lab Microbial Technol, Qingdao 266237, Peoples R China.
   [Xun, Luying] Washington State Univ, Sch Mol Biosci, Dept Chem, Pullman, WA 99164 USA.
C3 Shandong University; Washington State University
RP Liu, HW (corresponding author), 72 Binhai Rd, Qingdao 266237, Peoples R China.; Xun, LY (corresponding author), Washington State Univ, Smith Ctr 519, Pullman, WA 99164 USA.
EM luying_xun@vetmed.wsu.edu; liuhuaiwei@sdu.edu.cn
RI Liu, Huaiwei/GOG-9430-2022
OI Xia, Yongzhen/0000-0001-9950-1910
FU National Key R&D Program of China [2018YFA0901200]; National Natural
   Science Foundation of China [91951202]; State Key Laboratory of
   Microbial Technology, Shandong University
FX The work was financially supported by grants from the National Key R&D
   Program of China (2018YFA0901200) , and the National Natural Science
   Foundation of China (91951202) . The authors also thank the support from
   State Key Laboratory of Microbial Technology, Shandong University.
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NR 48
TC 18
Z9 20
U1 4
U2 30
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2213-2317
J9 REDOX BIOL
JI Redox Biol.
PD NOV
PY 2021
VL 47
AR 102169
DI 10.1016/j.redox.2021.102169
EA OCT 2021
PG 13
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA XA1OC
UT WOS:000720424500002
PM 34688157
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Roohbakhsh, A
   Karimi, G
   Iranshahi, M
AF Roohbakhsh, Ali
   Karimi, Gholamreza
   Iranshahi, Mehrdad
TI Carotenoids in the treatment of diabetes mellitus and its complications:
   A mechanistic review
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Review
DE Lycopene; beta-Carotene; Astaxanthin; Nephropathy; Diabetes mellitus;
   Retinopathy
ID WHITE ADIPOSE-TISSUE; OXIDATIVE STRESS; SERUM CAROTENOIDS;
   BETA-CAROTENE; INSULIN-RESISTANCE; METABOLIC SYNDROME; ALPHA-TOCOPHEROL;
   PLASMA-CONCENTRATIONS; CATARACT-EXTRACTION; MEMORY IMPAIRMENTS
AB Carotenoids are a large class of natural antioxidants that occur in many vegetables, foods and other natural sources. To date, a large number of biological properties have been reported from carotenoids, particularly protective effects against diabetes mellitus (DM), cancer, and neurodegenerative, metabolic and cardiovascular diseases. However, recent studies including clinical evidences, have shown that carotenoids play a role in the treatment of diabetes via enhancing insulin sensitivity. They are also able to protect the body from long-term consequences of diabetes including infectious diseases, nephropathy, neuronal and eye abnormalities. In this review, we try to discuss the mechanisms behind the biological effects of carotenoids for the prevention and treatment of DM and its complications. The authors believe that carotenoids will have a prominent place in the treatment of DM and its complications in the future. (C) 2017 Elsevier Masson SAS. All rights reserved.
C1 [Roohbakhsh, Ali; Karimi, Gholamreza] Mashhad Univ Med Sci, Sch Pharm, Pharmaceut Res Ctr, Mashhad, Iran.
   [Iranshahi, Mehrdad] Mashhad Univ Med Sci, Sch Pharm, Biotechnol Res Ctr, Mashhad, Iran.
C3 Mashhad University of Medical Sciences; Mashhad University of Medical
   Sciences
RP Iranshahi, M (corresponding author), Mashhad Univ Med Sci, Sch Pharm, Biotechnol Res Ctr, Mashhad, Iran.
EM Iranshahim@mums.ac.ir
RI Karimi, Gholamreza/AAD-6369-2019; Iranshahi, Mehrdad/E-3664-2014;
   Roohbakhsh, Ali/H-4060-2017
OI Roohbakhsh, Ali/0000-0001-5032-4263
FU Mashhad University of Medical Sciences Research Council
FX This study was partially supported by the Mashhad University of Medical
   Sciences Research Council.
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NR 120
TC 97
Z9 103
U1 4
U2 53
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD JUL
PY 2017
VL 91
BP 31
EP 42
DI 10.1016/j.biopha.2017.04.057
PG 12
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA FB8PB
UT WOS:000406399900004
PM 28445831
DA 2025-06-11
ER

PT J
AU O'Brien, PD
   Hinder, LM
   Callaghan, BC
   Feldman, EL
AF O'Brien, Phillipe D.
   Hinder, Lucy M.
   Callaghan, Brian C.
   Feldman, Eva L.
TI Neurological consequences of obesity
SO LANCET NEUROLOGY
LA English
DT Review
ID BODY-MASS INDEX; HIGH-FAT DIET; ENDOPLASMIC-RETICULUM STRESS;
   NERVOUS-SYSTEM ACTIVITY; INTENTIONAL WEIGHT-LOSS; WHITE ADIPOSE-TISSUE;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; CALORIC RESTRICTION; BARIATRIC
   SURGERY
AB The high prevalence of obesity is associated with an enormous medical, social, and economic burden. The metabolic dysfunction, dyslipidaemia, and inflammation caused by obesity contribute to the development of a wide variety of disorders and effects on the nervous system. In the CNS, mild cognitive impairment can be attributed to obesity-induced alterations in hippocampal structure and function in some patients. Likewise, compromised hypothalamic function and subsequent defects in maintaining whole-body energy balance might be early events that contribute to weight gain and obesity development. In the peripheral nervous system, obesity-driven alterations in the autonomic nervous system prompt imbalances in sympathetic-parasympathetic activity, while alterations in the sensory-somatic nervous system underlie peripheral polyneuropathy, a common complication of diabetes. Pharmacotherapy and bariatric surgery are promising interventions for people with obesity that can improve neurological function. However, lifestyle interventions via dietary changes and exercise are the preferred approach to combat obesity and reduce its associated health risks.
C1 [O'Brien, Phillipe D.; Hinder, Lucy M.; Callaghan, Brian C.; Feldman, Eva L.] Univ Michigan, Dept Neurol, Ann Arbor, MI 48109 USA.
C3 University of Michigan System; University of Michigan
RP Feldman, EL (corresponding author), Univ Michigan, Dept Neurol, Ann Arbor, MI 48109 USA.
EM efeldman@umich.edu
RI O'Brien, Phillipe/W-4268-2019
OI Feldman, Eva/0000-0002-9162-2694; Hinder, Lucy/0000-0002-5206-8010
FU National Institutes of Health [R24 DK082841, R01 DK107956, K23
   NS079417]; Novo Nordisk Foundation [NNF14SA0006]; Program for Neurology
   Research Discovery; A Alfred Taubman Medical Research Institute;
   National Institute of Diabetes and Digestive and Kidney Diseases
   [P30DK020572] Funding Source: NIH RePORTER
FX ELF and BCC received funding support from the National Institutes of
   Health (R24 DK082841 and R01 DK107956 to ELF; K23 NS079417 to BCC), the
   Novo Nordisk Foundation (NNF14SA0006), the Program for Neurology
   Research & Discovery, and the A Alfred Taubman Medical Research
   Institute.
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NR 130
TC 352
Z9 375
U1 6
U2 107
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1474-4422
EI 1474-4465
J9 LANCET NEUROL
JI Lancet Neurol.
PD JUN
PY 2017
VL 16
IS 6
BP 465
EP 477
DI 10.1016/S1474-4422(17)30084-4
PG 13
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA EU1WD
UT WOS:000400815800013
PM 28504110
OA Green Accepted
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Bartke, A
   Sun, L
   Fang, Y
   Hill, C
AF Bartke, A.
   Sun, L.
   Fang, Y.
   Hill, C.
TI Growth hormone actions during development influence adult phenotype and
   longevity
SO EXPERIMENTAL GERONTOLOGY
LA English
DT Article
DE Aging; Growth hormone; Nutrition; Developmental origin of disease; Ames
   dwarf mice; Developmental programming; Litter crowding
ID AMES DWARF MICE; LIFE-SPAN EXTENSION; CALORIE RESTRICTION; METABOLIC
   SYNDROME; TRANSGENIC MICE; MUTANT MICE; INSULIN; AGE; DISEASE; OBESITY
AB There is considerable evidence that exposure to undernutrition, overnutrition, stress or endocrine disruptors during fetal development can increase the probability of obesity, hypertension, cardiovascular disease and other problems in adult life. In contrast to these findings, reducing early postnatal growth by altering maternal diet or number of pups in a litter can increase longevity. In hypopituitary Ames dwarf mice, which are remarkably long lived, a brief period of growth hormone therapy starting at 1 or 2 weeks of age reduces longevity and normalizes ("rescues") multiple aging-related traits. Collectively, these findings indicate that nutritional and hormonal signals during development can have profound impact on the trajectory of aging. We suspect that altered "programming" of aging during development may represent one of the mechanisms of the Developmental Origins of Health and Disease (DOHaD) and the detrimental effects of "catch-up" growth. (C) 2016 Elsevier Inc. All rights reserved.
C1 [Bartke, A.; Sun, L.; Fang, Y.; Hill, C.] Southern Illinois Univ, Dept Internal Med, Sch Med, Springfield, IL USA.
C3 Southern Illinois University System; Southern Illinois University
RP Bartke, A (corresponding author), SIU Sch Med, 801 N Rutledge,POB 9628, Springfield, IL 62794 USA.
EM abartke@siumed.edu
RI Hill, Cristal M./AFY-8900-2022; Bartke, Andrzej/D-6640-2017
OI Bartke, Andrzej/0000-0002-2569-557X; Hill, Cristal
   M./0000-0002-0722-9049
FU NIH [P01AG031736, R01AG019899]
FX Work described in this article was supported by the NIH P01AG031736 and
   R01AG019899. We thank Dr. O. Arum, A. Spong and other members of our
   laboratory who were importantly involved in various stages of this
   research and we apologize to those whose work is pertinent to the
   discussed issues that we have failed to mention or cite.
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NR 68
TC 11
Z9 12
U1 0
U2 15
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0531-5565
EI 1873-6815
J9 EXP GERONTOL
JI Exp. Gerontol.
PD DEC
PY 2016
VL 86
SI SI
BP 22
EP 27
DI 10.1016/j.exger.2015.12.011
PG 6
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA EG1WU
UT WOS:000390825600004
PM 26752217
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Zambrano, E
   Ibáñez, C
   Martínez-Samayoa, PM
   Lomas-Soria, C
   Durand-Carbajal, M
   Rodríguez-González, GL
AF Zambrano, Elena
   Ibanez, Carlos
   Martinez-Samayoa, Paola M.
   Lomas-Soria, Consuelo
   Durand-Carbajal, Marta
   Rodriguez-Gonzalez, Guadalupe L.
TI Maternal Obesity: Lifelong Metabolic Outcomes for Offspring from Poor
   Developmental Trajectories During the Perinatal Period
SO ARCHIVES OF MEDICAL RESEARCH
LA English
DT Review
DE Developmental programming; Dietary intervention; Fetal programming;
   Maternal obesity; Metabolic syndrome; Offspring phenotype
ID GESTATIONAL WEIGHT-GAIN; BODY-MASS INDEX; JUNK FOOD DIET;
   LIPID-METABOLISM; PHYSICAL-ACTIVITY; PREGNANT-WOMEN; ADIPOSE-TISSUE;
   FETAL-GROWTH; FATTY-ACIDS; INSULIN-RESISTANCE
AB The prevalence of obesity in women of reproductive age is increasing in developed and developing countries around the world. Human and animal studies indicate that maternal obesity adversely impacts both maternal health and offspring phenotype, predisposing them to chronic diseases later in life including obesity, dyslipidemia, type 2 diabetes mellitus, and hypertension. Several mechanisms act together to produce these adverse health effects including programming of hypothalamic appetite-regulating centers, increasing maternal, fetal and offspring glucocorticoid production, changes in maternal metabolism and increasing maternal oxidative stress. Effective interventions during human pregnancy are needed to prevent both maternal and offspring metabolic dysfunction due to maternal obesity. This review addresses the relationship between maternal obesity and its negative impact on offspring development and presents some maternal intervention studies that propose strategies to prevent adverse offspring metabolic outcomes. (C) 2016 IMSS. Published by Elsevier Inc.
C1 [Zambrano, Elena; Ibanez, Carlos; Martinez-Samayoa, Paola M.; Lomas-Soria, Consuelo; Durand-Carbajal, Marta; Rodriguez-Gonzalez, Guadalupe L.] Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Reprod Biol, Mexico City, DF, Mexico.
C3 Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran -
   Mexico
RP Zambrano, E (corresponding author), Vasco de Quiroga 15,Belisario Dominguez Secc 16, Mexico City 14080, DF, Mexico.
EM zamgon@unam.mx
RI Rodríguez-González, Guadalupe/AAB-1291-2021; Ibanez Chavez, Carlos
   Alberto/AAG-2398-2020
OI Ibanez Chavez, Carlos Alberto/0000-0002-3435-497X; Zambrano,
   Elena/0000-0002-0362-9117; Lomas, Consuelo/0000-0003-0390-7305;
   Rodriguez Gonzalez, Guadalupe Leticia/0000-0002-3267-4793; Durand
   Carbajal, Marta Margarita/0009-0007-5354-692X
FU CONACyT (Consejo Nacional de Ciencia y Tecnologia) Grant [155166]
FX This work was supported by CONACyT (Consejo Nacional de Ciencia y
   Tecnologia) Grant #155166.
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NR 138
TC 76
Z9 83
U1 2
U2 38
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0188-4409
EI 1873-5487
J9 ARCH MED RES
JI Arch. Med. Res.
PD JAN
PY 2016
VL 47
IS 1
BP 1
EP 12
DI 10.1016/j.arcmed.2016.01.004
PG 12
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA DI8LF
UT WOS:000373751800001
PM 26827819
DA 2025-06-11
ER

PT J
AU Gang, L
   Wei-Hua, L
   Rong, A
   Jian-Hong, Y
   Zi-Hua, Z
   Zhong-Zhi, T
AF Gang, Li
   Wei-Hua, Lu
   Rong, Ai
   Jian-Hong, Yang
   Zi-Hua, Zhou
   Zhong-Zhi, Tang
TI Serum Gamma-glutamyltransferase Levels Predict the Progression of
   Coronary Artery Calcification in Adults With Type 2 Diabetes Mellitus
SO ANGIOLOGY
LA English
DT Article
DE diabetes; coronary artery calcification; gamma-glutamyltransferase;
   computed tomography; progression
ID ALL-CAUSE MORTALITY; MIDDLE-AGED MEN; METABOLIC SYNDROME;
   CARDIOVASCULAR-DISEASE; INSULIN-RESISTANCE; OXIDATIVE STRESS; PROGNOSTIC
   VALUE; LIVER-ENZYMES; ASSOCIATION; RISK
AB Progression of coronary artery calcification (CAC) may be more predictive of future coronary heart disease events than a baseline CAC score. We determined whether serum gamma-glutamyltransferase (GGT) activity can independently predict the progression of CAC in adults with type 2 diabetes mellitus (T2DM). Patients (n = 326) without symptomatic cardiovascular (CV) disease were evaluated by CAC imaging. The CAC scores were assessed at baseline and after 20 +/- 4 months. Serum GGT activities were significantly higher in progressors compared with nonprogressors (39 +/- 16 vs 27 +/- 11 U/L, P < .001). Multivariable analyses demonstrated that GGT activity retained a strong association with CAC progression after adjustment for CV risk factors. Additionally, there was a graded association between GGT activity quartile and annualized CAC progression. In asymptomatic patients with T2DM, we prospectively found that serum GGT activity may be an independent predictor of CAC progression but not a predictor of CAC incidence.
C1 [Gang, Li; Wei-Hua, Lu; Jian-Hong, Yang; Zhong-Zhi, Tang] Guangzhou Mil Command, Wuhan Gen Hosp, Emergency Dept, Wuhan 430064, Peoples R China.
   [Rong, Ai] Huazhong Agr Univ, Coll Foreign Language, Wuhan, Peoples R China.
   [Zi-Hua, Zhou] Huazhong Univ Sci & Technol, Tongji Med Coll, Union Hosp, Inst Cardiol, Wuhan 430074, Peoples R China.
C3 Huazhong Agricultural University; Huazhong University of Science &
   Technology
RP Gang, L (corresponding author), Guangzhou Mil Command, Wuhan Gen Hosp, Emergency Dept, Wuhan 430064, Peoples R China.
EM marty007@163.com; zhongzt2007@yahoo.com.cn
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NR 46
TC 3
Z9 3
U1 0
U2 4
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0003-3197
EI 1940-1574
J9 ANGIOLOGY
JI Angiology
PD AUG
PY 2015
VL 66
IS 7
BP 667
EP 674
DI 10.1177/0003319714548566
PG 8
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA CN6XK
UT WOS:000358577600012
PM 25163771
DA 2025-06-11
ER

PT J
AU Gorman, S
   Black, LJ
   Feelisch, M
   Hart, PH
   Weller, R
AF Gorman, Shelley
   Black, Lucinda J.
   Feelisch, Martin
   Hart, Prue H.
   Weller, Richard
TI Can Skin Exposure to Sunlight Prevent Liver Inflammation?
SO NUTRIENTS
LA English
DT Review
ID NONALCOHOLIC FATTY LIVER; VITAMIN-D DEFICIENCY; 25-HYDROXYVITAMIN D
   LEVEL; NITRIC-OXIDE; INSULIN-RESISTANCE; OXIDATIVE STRESS; HEME
   OXYGENASE-1; METABOLIC SYNDROME; NUCLEAR RECEPTOR; UVA IRRADIATION
AB Liver inflammation contributes towards the pathology of non-alcoholic fatty liver disease (NAFLD). Here we discuss how skin exposure to sunlight may suppress liver inflammation and the severity of NAFLD. Following exposure to sunlight-derived ultraviolet radiation (UVR), the skin releases anti-inflammatory mediators such as vitamin D and nitric oxide. Animal modeling studies suggest that exposure to UVR can prevent the development of NAFLD. Association studies also support a negative link between circulating 25-hydroxyvitamin D and NAFLD incidence or severity. Clinical trials are in their infancy and are yet to demonstrate a clear beneficial effect of vitamin D supplementation. There are a number of potentially interdependent mechanisms whereby vitamin D could dampen liver inflammation, by inhibiting hepatocyte apoptosis and liver fibrosis, modulating the gut microbiome and through altered production and transport of bile acids. While there has been a focus on vitamin D, other mediators induced by sun exposure, such as nitric oxide may also play important roles in curtailing liver inflammation.
C1 [Gorman, Shelley; Black, Lucinda J.; Hart, Prue H.] Univ Western Australia, Telethon Kids Inst, Subiaco, WA 6008, Australia.
   [Feelisch, Martin] Univ Southampton, Southampton Gen Hosp, Clin & Expt Sci, Fac Med, Southampton SO16 6YD, Hants, England.
   [Weller, Richard] Univ Edinburgh, MRC Ctr Inflammat Res, Edinburgh EH16 4TJ, Midlothian, Scotland.
C3 The Kids Research Institute Australia; University of Western Australia;
   University of Southampton; University of Edinburgh
RP Gorman, S (corresponding author), Univ Western Australia, Telethon Kids Inst, 100 Roberts Rd, Subiaco, WA 6008, Australia.
EM shelley.gorman@telethonkids.org.au; lucinda.black@telethonkids.org.au;
   M.Feelisch@soton.ac.uk; prue.hart@telethonkids.org.au;
   richard.weller@ed.ac.uk
RI Black, Lucinda/C-1930-2015; Gorman, Shelley/R-9953-2017; Weller,
   Richard/B-4954-2010; Hart, Prue/AFL-0919-2022; Feelisch,
   Martin/C-3042-2008
OI Gorman, Shelley/0000-0002-7111-6735; Black, Lucinda/0000-0003-4727-4773;
   Weller, Richard/0000-0003-2550-9586; Hart, Prue/0000-0001-7207-6467;
   Feelisch, Martin/0000-0003-2320-1158
FU BrightSpark Foundation; University of Western Australia; Telethon Kids
   Institute; UK Medical Research Council; National Health and Medical
   Research Council (Australia); MRC [G1001536] Funding Source: UKRI
FX We acknowledge funding from the BrightSpark Foundation, the University
   of Western Australia, the Telethon Kids Institute, the UK Medical
   Research Council, and the National Health and Medical Research Council
   (Australia).
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NR 103
TC 17
Z9 17
U1 0
U2 15
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD MAY
PY 2015
VL 7
IS 5
BP 3219
EP 3239
DI 10.3390/nu7053219
PG 21
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA CK5CT
UT WOS:000356240500010
PM 25951129
OA Green Accepted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Walker, AK
   Jacobs, RL
   Watts, JL
   Rottiers, V
   Jiang, K
   Finnegan, DM
   Shioda, T
   Hansen, M
   Yang, F
   Niebergall, LJ
   Vance, DE
   Tzoneva, M
   Hart, AC
   Näär, AM
AF Walker, Amy K.
   Jacobs, Rene L.
   Watts, Jennifer L.
   Rottiers, Veerle
   Jiang, Karen
   Finnegan, Deirdre M.
   Shioda, Toshi
   Hansen, Malene
   Yang, Fajun
   Niebergall, Lorissa J.
   Vance, Dennis E.
   Tzoneva, Monika
   Hart, Anne C.
   Naeaer, Anders M.
TI A Conserved SREBP-1/Phosphatidylcholine Feedback Circuit Regulates
   Lipogenesis in Metazoans
SO CELL
LA English
DT Article
ID PHOSPHATIDYLETHANOLAMINE-N-METHYLTRANSFERASE; PHOSPHOCHOLINE
   CYTIDYLYLTRANSFERASE-ALPHA; ENDOPLASMIC-RETICULUM STRESS;
   NUCLEOTIDE-EXCHANGE PROTEIN; FATTY-ACID SYNTHESIS; PLASMA HIGH-DENSITY;
   CAENORHABDITIS-ELEGANS; HEPATIC STEATOSIS; LIVER-DISEASE; BREFELDIN-A
AB Sterol regulatory element-binding proteins (SREBPs) activate genes involved in the synthesis and trafficking of cholesterol and other lipids and are critical for maintaining lipid homeostasis. Aberrant SREBP activity, however, can contribute to obesity, fatty liver disease, and insulin resistance, hallmarks of metabolic syndrome. Our studies identify a conserved regulatory circuit in which SREBP-1 controls genes in the one-carbon cycle, which produces the methyl donor S-adenosylmethionine (SAMe). Methylation is critical for the synthesis of phosphatidylcholine (PC), a major membrane component, and we find that blocking SAMe or PC synthesis in C. elegans, mouse liver, and human cells causes elevated SREBP-1-dependent transcription and lipid droplet accumulation. Distinct from negative regulation of SREBP-2 by cholesterol, our data suggest a feedback mechanism whereby maturation of nuclear, transcriptionally active SREBP-1 is controlled by levels of PC. Thus, nutritional or genetic conditions limiting SAMe or PC production may activate SREBP-1, contributing to human metabolic disorders.
C1 [Walker, Amy K.; Jiang, Karen; Finnegan, Deirdre M.; Shioda, Toshi; Yang, Fajun; Hart, Anne C.; Naeaer, Anders M.] Massachusetts Gen Hosp, Ctr Canc, Charlestown, MA 02129 USA.
   [Rottiers, Veerle; Yang, Fajun; Naeaer, Anders M.] Harvard Univ, Dept Cell Biol, Sch Med, Boston, MA 02115 USA.
   [Jacobs, Rene L.] Univ Alberta, Dept Agr Food & Nutr Sci, Ag Ctr D 1 32, Edmonton, AB T6G 2M7, Canada.
   [Watts, Jennifer L.; Tzoneva, Monika] Washington State Univ, Sch Mol Biosci, Pullman, WA 99164 USA.
   [Hansen, Malene] Sanford Burnham Inst Med Res, La Jolla, CA 92037 USA.
   [Niebergall, Lorissa J.; Vance, Dennis E.] Univ Alberta, Dept Biochem, Edmonton, AB T6G 2M7, Canada.
C3 Harvard University; Harvard University Medical Affiliates; Massachusetts
   General Hospital; Harvard University; Harvard Medical School; University
   of Alberta; Washington State University; Sanford Burnham Prebys Medical
   Discovery Institute; University of Alberta
RP Walker, AK (corresponding author), Massachusetts Gen Hosp, Ctr Canc, Bldg 149,13th St, Charlestown, MA 02129 USA.
EM amy_walker@mac.com; naar@helix.mgh.harvard.edu
RI Watts, Jennifer/AAC-7425-2020
OI Jacobs, Rene/0000-0002-5525-1355; Watts, Jennifer/0000-0003-4349-0639
FU Claflin Distinguished Scholar Award [R01DK084352]; The Paul F. Glenn
   Laboratories for the Biological Mechanisms of Aging at Harvard Medical
   School; NIH [R01DK078332, R01GM071449, R01DK074114]; Canadian Institutes
   of Health Research [MOP 5182, 4487]
FX We thank T. Keith Blackwell for advice on examining ER stress in C.
   elegans as well as members of the Naar lab and Drs. Nick Dyson,
   Johnathan Whetstine, Andrew Gladden, and Tom Rapoport for helpful
   discussions. We express our gratitude to Drs. Stefan Taubert and Raul
   Mostoslavsky for critical reading of the manuscript. We thank Dr.
   Michael Brown for the SRD13A, SCAP-deficient cells and Dr. Joachim
   Seemann for advice on S1P staining. We thank the Caenorhabditis Genetics
   Center for strains. Funding for A. K. W. was provided by the Claflin
   Distinguished Scholar Award and R01DK084352. Funding for A.M.N. was
   provided by The Paul F. Glenn Laboratories for the Biological Mechanisms
   of Aging at Harvard Medical School and the following grants from NIH:
   R01DK078332 and R01GM071449. Funding for J.L.W. was provided by NIH
   grant R01DK074114. Funding for research in the D.E.V. and R.L.J. labs
   was from the Canadian Institutes of Health Research (MOP 5182 and 4487).
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NR 55
TC 330
Z9 387
U1 0
U2 60
PU CELL PRESS
PI CAMBRIDGE
PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA
SN 0092-8674
J9 CELL
JI Cell
PD NOV 11
PY 2011
VL 147
IS 4
BP 840
EP 852
DI 10.1016/j.cell.2011.09.045
PG 13
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA 846LM
UT WOS:000296902300017
PM 22035958
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Hao, ZH
   Zhao, YL
   Zhu, QX
   Ge, YH
   Liu, ZB
   Chen, YX
   Jiao, LJ
   Zhao, X
   Wang, X
   Wang, J
   Zhou, J
   Hao, HY
   Hao, YM
   Zhou, H
   Wang, M
   Zhang, LH
AF Hao, Zhihua
   Zhao, Yuliang
   Zhu, Qiuxiao
   Ge, Yanhong
   Liu, Zibo
   Chen, Yanxia
   Jiao, Lijing
   Zhao, Xin
   Wang, Xing
   Wang, Jing
   Zhou, Jing
   Hao, Huiyao
   Hao, Yongmei
   Zhou, Hong
   Wang, Mian
   Zhang, Lihui
TI Empagliflozin combined with short-term intensive insulin therapy
   improves glycemic variability and 1,5-anhydroglucitol in patients with
   type 2 diabetes: a randomized clinical trial
SO INTERNATIONAL JOURNAL OF DIABETES IN DEVELOPING COUNTRIES
LA English
DT Article
DE Type 2 diabetes mellitus; Glycemic control; Glycemic variability; Flash
   glucose monitoring; Empagliflozin; 1,5-Anhydroglucitol
ID PREMIXED INSULIN; OXIDATIVE STRESS
AB Objective We aimed to compare glycemic variability (GV) parameters using both a flash glucose monitoring (FGM) system and cardiometabolic risk parameters in hospitalized patients with type 2 diabetes mellitus (T2DM) between cohorts receiving short-term intensive insulin infusion (STII) plus empagliflozin (EMPA) combination therapy vs. STII therapy alone.Methods In a 2-week, open-label, randomized, parallel-group clinical trial, newly diagnosed patients with T2DM [fasting plasma glucose (FPG) > 11.1 mmol/L or hemoglobin A(1c) (HbA(1c)) > 9.0%] or patients with poor glycemic control (HbA(1c) > 7.0%) on oral antidiabetic drugs (OAD) received either STII+EMPA therapy (n = 30) or STII therapy alone (n = 30). FGM was carried over 14 days, and the data were used to calculate time in range (TIR [3.9-10 mmol/L]) and compare GV parameters. 1,5-Anhydroglucitol (1,5-AG) and cardiometabolic indicators of oxidative stress, inflammation, and vascular endothelial function were also compared.Results After treatment, the TIR percentage was significantly higher (p < 0.05), and the time below range (TBR; < 3.9 mmol/L) was significantly lower (p < 0.05) in the STII+EMPA group than that in the STII group. The various measured glycemic parameters were significantly lower, and the average daily dose of insulin was also significantly lower in patients with STII+EMPA treatment (all p < 0.05). Plasma 1,5-AG levels were significantly higher (p < 0.05) in the STII+EMPA group than that in the control group.Conclusions Newly diagnosed patients with T2DM or with poor glycemic control on OAD attained greater benefit and lower GV from STII+EMPA treatment than that for STII treatment alone. The 1,5-AG marker is a good indicator of the effects of short-term glycemic control.
C1 [Hao, Zhihua; Zhao, Yuliang; Zhu, Qiuxiao; Ge, Yanhong; Liu, Zibo; Chen, Yanxia; Jiao, Lijing; Zhao, Xin; Wang, Xing; Wang, Jing; Zhou, Jing; Hao, Huiyao; Hao, Yongmei; Zhou, Hong; Wang, Mian; Zhang, Lihui] Hebei Med Univ, Hosp 2, Dept Endocrinol, Shijiazhuang 050000, Hebei, Peoples R China.
   [Hao, Zhihua; Zhao, Yuliang] Hebei Med Univ, Hosp 2, Off Acad Res, Shijiazhuang 050000, Hebei, Peoples R China.
C3 Hebei Medical University; Hebei Medical University
RP Zhang, LH (corresponding author), Hebei Med Univ, Hosp 2, Dept Endocrinol, Shijiazhuang 050000, Hebei, Peoples R China.
EM haozhihua@hb2h.com; 624602085@qq.com; 583644953@qq.com;
   gyhong2011@126.com; 814314999@qq.com; chenbs2013@163.com;
   jiaolijing163@163.com; beginning246@163.com; wangxingnfm@163.com;
   412034469@qq.com; zhoujing195@163.com; haohuiyao2013@aliyun.com;
   hym8601@126.com; zhoubs2013@163.com; wangmian66@sina.com;
   zhanglihui10510@163.com
RI Zhou, Hongru/ADZ-1438-2022; Zhao, Yuliang/LTZ-5867-2024; chen,
   Yanxia/HCI-8515-2022; Lai, Xiaoyang/L-5445-2019
FU We thank all the participants of this study and the medical care
   professionals for their valuable contributions. We would like to thank
   Editage (www.editage.cn) for English language editing.
FX We thank all the participants of this study and the medical care
   professionals for their valuable contributions. We would like to thank
   Editage (www.editage.cn) for English language editing.
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NR 28
TC 0
Z9 0
U1 1
U2 6
PU SPRINGER INDIA
PI NEW DELHI
PA 7TH FLOOR, VIJAYA BUILDING, 17, BARAKHAMBA ROAD, NEW DELHI, 110 001,
   INDIA
SN 0973-3930
EI 1998-3832
J9 INT J DIABETES DEV C
JI Int. Diabetes Dev. Ctries.
PD SEP
PY 2024
VL 44
IS 3
BP 486
EP 495
DI 10.1007/s13410-023-01271-8
EA OCT 2023
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA C0T0D
UT WOS:001098061500002
DA 2025-06-11
ER

PT J
AU Luis, C
   Soares, R
   Baylina, P
   Fernandes, R
AF Luis, Carla
   Soares, Raquel
   Baylina, Pilar
   Fernandes, Ruben
TI Underestimated Prediabetic Biomarkers: Are We Blind to Their Strategy?
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Review
DE diabetes; biomarkers; early diagnosis; galectin-3; ophthalmate;
   fetuin-A; prediabetes
ID FATTY LIVER-DISEASE; FETUIN-A LEVELS; INSULIN-RESISTANCE; OXIDATIVE
   STRESS; OPHTHALMIC ACID; METABOLIC SYNDROME; GALECTIN-3; OBESITY;
   INFLAMMATION; PATHOGENESIS
AB Type 2 Diabetes (T2D) is currently one of the fastest growing health challenging, a non-communicable disease result of the XXI century lifestyle. Given its growing incidence and prevalence, it became increasingly imperative to develop new technologies and implement new biomarkers for early diagnosis in order to promote lifestyle changes and thus cause a setback of the disease. Promising biomarkers have been identified as predictive of T2D development; however, none of them have yet been implemented in clinical practice routine. Moreover, many prediabetic biomarkers can also represent potential therapeutical targets in disease management. Previous studies have identified the most popular biomarkers, which are being thoroughly investigated. However, there are some biomarkers with promising preliminary results with limited associated studies; hence there is still much to be understood about its mechanisms and associations in T2D pathophysiology. This work identifies and discusses the promising results of Galectin-3, Ophthalmate and Fetuin-A.
C1 [Luis, Carla; Baylina, Pilar; Fernandes, Ruben] Technol & Innovat Ctr PORT, Lab Med & Ind Biotechnol LABMI, Porto Res, Porto, Portugal.
   [Luis, Carla; Soares, Raquel] Fac Med Univ Porto, Dept Biomed, Porto, Portugal.
   [Luis, Carla; Soares, Raquel; Baylina, Pilar; Fernandes, Ruben] Univ Porto, Inst Invest, Inovacao Saude i3S, Porto, Portugal.
   [Baylina, Pilar; Fernandes, Ruben] Inst Politecn Porto, ESS IPP, Escola Super Saude, Porto, Portugal.
C3 Instituto Politecnico do Porto; Universidade do Porto; Universidade do
   Porto; i3S - Instituto de Investigacao e Inovacao em Saude, Universidade
   do Porto; Instituto Politecnico do Porto
RP Luis, C; Fernandes, R (corresponding author), Technol & Innovat Ctr PORT, Lab Med & Ind Biotechnol LABMI, Porto Res, Porto, Portugal.; Luis, C (corresponding author), Fac Med Univ Porto, Dept Biomed, Porto, Portugal.; Luis, C; Fernandes, R (corresponding author), Univ Porto, Inst Invest, Inovacao Saude i3S, Porto, Portugal.; Fernandes, R (corresponding author), Inst Politecn Porto, ESS IPP, Escola Super Saude, Porto, Portugal.
EM rfernandes@ess.ipp.pt; rfernandes@ess.ipp.pt
RI Fernandes, Ruben/AFK-8036-2022; Soares, Raquel/L-2349-2013; Luís,
   Carla/AAY-5181-2020; BAYLINA MACHADO, PILAR/B-5134-2010
OI Luis, Carla/0000-0002-5292-6337; Fernandes, Ruben/0000-0001-8933-3984;
   BAYLINA MACHADO, PILAR/0000-0002-3740-862X
FU FCT Fundacao para a Ciencia e Tecnologia [REF UID/BIM/04293/2013,
   SAICT2016/FEDER/BIO4DIA/BTI, SFRH/BD/146489/2019]; Fundação para a
   Ciência e a Tecnologia [SFRH/BD/146489/2019] Funding Source: FCT
FX This work was supported by FCT Fundacao para a Ciencia e Tecnologia (REF
   UID/BIM/04293/2013) and by the following scholarships: (Ref.
   SAICT2016/FEDER/BIO4DIA/BTI) and (SFRH/BD/146489/2019).
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NR 59
TC 2
Z9 2
U1 0
U2 10
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD MAR 7
PY 2022
VL 13
AR 805837
DI 10.3389/fendo.2022.805837
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA ZZ9TH
UT WOS:000773605400001
PM 35321333
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Turkmen, K
   Ozer, H
   Kusztal, M
AF Turkmen, Kultigin
   Ozer, Hakan
   Kusztal, Mariusz
TI The Relationship of Epicardial Adipose Tissue and Cardiovascular Disease
   in Chronic Kidney Disease and Hemodialysis Patients
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Article
DE epicardial adipose tissue; cardiovascular morbidity and mortality;
   hemodialysis
ID CORONARY-ARTERY-DISEASE; STAGE RENAL-DISEASE; FATTY LIVER-DISEASE;
   TO-LYMPHOCYTE RATIO; OXIDATIVE STRESS; ATHEROSCLEROSIS/CALCIFICATION
   SYNDROME; INFLAMMATORY PROFILE; METABOLIC SYNDROME; THICKNESS;
   CALCIFICATION
AB Cardiovascular diseases remain the most common cause of morbidity and mortality in chronic kidney disease patients undergoing hemodialysis. Epicardial adipose tissue (EAT), visceral fat depot of the heart, was found to be associated with coronary artery disease in cardiac and non-cardiac patients. Additionally, EAT has been proposed as a novel cardiovascular risk in the general population and in end-stage renal disease patients. It has also been shown that EAT, more than other subcutaneous adipose tissue deposits, acts as a highly active organ producing several bioactive adipokines, and proinflammatory and proatherogenic cytokines. Therefore, increased visceral adiposity is associated with proinflammatory activity, impaired insulin sensitivity, increased risk of atherosclerosis, and high morbidity and mortality in hemodialysis patients. In the present review, we aimed to demonstrate the role of EAT in the pathophysiological mechanisms of increased cardiovascular morbidity and mortality in hemodialysis patients.
C1 [Turkmen, Kultigin; Ozer, Hakan] Necmettin Erbakan Univ, Meram Med Fac, Dept Internal Med, Div Nephrol, TR-42090 Konya, Turkey.
   [Kusztal, Mariusz] Wroclaw Med Univ, Dept Nephrol & Transplantat Med, PL-50367 Wroclaw, Poland.
C3 Necmettin Erbakan University; Wroclaw Medical University
RP Turkmen, K (corresponding author), Necmettin Erbakan Univ, Meram Med Fac, Dept Internal Med, Div Nephrol, TR-42090 Konya, Turkey.
EM ucmdkt@gmail.com; hakanozer724@gmail.com; mariusz.kusztal@umed.wroc.pl
RI Kusztal, Mariusz/AAY-5669-2020; Turkmen, Kultigin/AFR-4244-2022; Özer,
   Hakan/HKN-9433-2023
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NR 91
TC 8
Z9 8
U1 0
U2 12
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD MAR
PY 2022
VL 11
IS 5
AR 1308
DI 10.3390/jcm11051308
PG 14
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA ZT1LC
UT WOS:000768916000001
PM 35268399
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Liu, L
   Li, YM
   Chen, Q
AF Liu, Lei
   Li, Yimei
   Chen, Quan
TI The Emerging Role of FUNDC1-Mediated Mitophagy in Cardiovascular
   Diseases
SO FRONTIERS IN PHYSIOLOGY
LA English
DT Review
DE mitochondria; mitochondria quality; dynamics; mitophagy; FUNDC1;
   cardiovascular diseases
ID MITOCHONDRIA-ASSOCIATED MEMBRANES; ENDOPLASMIC-RETICULUM; MEDIATED
   MITOPHAGY; FUNDC1; RECEPTOR; DYSFUNCTION; MECHANISMS; AUTOPHAGY;
   DYNAMICS; APOPTOSIS
AB Mitochondria are highly dynamic organelles and play essential role in ATP synthase, ROS production, innate immunity, and apoptosis. Mitochondria quality control is critical for maintaining the cellular function in response to cellular stress, growth, and differentiation Signals. Damaged or unwanted mitochondria are selectively removed by mitophagy, which is a crucial determinant of cell viability. Mitochondria-associated Endoplasmic Reticulum Membranes (MAMs) are the cellular structures that connect the ER and mitochondria and are involved in calcium signaling, lipid transfer, mitochondrial dynamic, and mitophagy. Abnormal mitochondrial quality induced by mitophagy impairment and MAMs dysfunction is associated with many diseases, including cardiovascular diseases (CVDs), metabolic syndrome, and neurodegenerative diseases. As a mitophagy receptor, FUNDC1 plays pivotal role in mitochondrial quality control through regulation of mitophagy and MAMs and is closely related to the occurrence of several types of CVDs. This review covers the regulation mechanism of FUNDC1-mediated mitophagy and MAMs formation, with a particular focus on its role in CVDs.
C1 [Liu, Lei; Li, Yimei] Chinese Acad Sci, Inst Zool, State Key Lab Membrane Biol, Beijing, Peoples R China.
   [Liu, Lei; Li, Yimei] Univ Chinese Acad Sci, Coll Life Sci, Beijing, Peoples R China.
   [Liu, Lei; Li, Yimei] Beijing Inst Stem Cell & Regenerat Med, Beijing, Peoples R China.
   [Chen, Quan] Nankai Univ, Coll Life Sci, State Key Lab Med Chem Biol, Interdisciplinary Ctr Cell Response, Tianjin, Peoples R China.
C3 Chinese Academy of Sciences; Institute of Zoology, CAS; Chinese Academy
   of Sciences; University of Chinese Academy of Sciences, CAS; Beijing
   Institute for Stem Cell & Regenerative Medicine; Nankai University
RP Chen, Q (corresponding author), Nankai Univ, Coll Life Sci, State Key Lab Med Chem Biol, Interdisciplinary Ctr Cell Response, Tianjin, Peoples R China.
EM chenq@nankai.edu.cn
FU Ministry of Science and Technology of China [2020YFA0803702,
   2019YFA0508601];  [91849201];  [31790404];  [91854105];  [31970716]
FX Funding This work was supported by Grants 2020YFA0803702 and
   2019YFA0508601 from the Ministry of Science and Technology of China and
   the National Natural Science Foundation of China (91849201, 31790404,
   91854105, and 31970716).
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NR 82
TC 23
Z9 25
U1 4
U2 35
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1664-042X
J9 FRONT PHYSIOL
JI Front. Physiol.
PD DEC 17
PY 2021
VL 12
AR 807654
DI 10.3389/fphys.2021.807654
PG 8
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA YA5RH
UT WOS:000738389600001
PM 34975548
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Bag, S
   Mondal, A
   Majumder, A
   Banik, A
AF Bag, Sagar
   Mondal, Anupam
   Majumder, Anusha
   Banik, Avishek
TI Tea and its phytochemicals: Hidden health benefits & modulation of
   signaling cascade by phytochemicals
SO FOOD CHEMISTRY
LA English
DT Article
DE Tea; Phytochemicals; Phytochemicals Bioactive compounds; Antioxidant
   activities; Signal transduction; Health benefits
ID GREEN TEA; OXIDATIVE STRESS; ANTIOXIDANT ACTIVITY; EXTRACT
   SUPPLEMENTATION; METABOLIC SYNDROME; PHENOLIC-COMPOUNDS;
   CAMELLIA-SINENSIS; POLYPHENOLS; CATECHINS; CONSUMPTION
AB Tea, one of the most widely consumed beverages, is prepared from the leaves of the Camellia sinensis. The promising health recompenses of tea have been linked to its different phenolic components, which have diverse biological characteristics. Tea also contains several flavonoids, alkaloids, phenolic, theanine, etc., which are associated with anti-oxidant characteristics and a variety of health benefits. It can also lower the pervasiveness of neurological disorders as well as prevent different types of cancer, metabolic syndromes, cardiovascular diseases, urinary stone, obesity, type 2 diabetes. Keeping in mind that tea helps to improve health and prevents many diseases, its consumption has been regarded as a "health-promoting habit" and current medical investigators have established the scientific basis for this concept over time. The current review provides new updated information and perspectives on the tea phytochemicals and their overall health benefits based on molecular processes, experimental studies, and clinical trials.
C1 [Bag, Sagar; Mondal, Anupam; Majumder, Anusha; Banik, Avishek] Presidency Univ, Sch Biotechnol, Lab Microbial Interact, Kolkata, W Bengal, India.
C3 Presidency University, Kolkata
RP Banik, A (corresponding author), Presidency Univ, Sch Biotechnol, Canal Bank Rd,DG Block Newtown,Act Area 1D, Kolkata 700156, W Bengal, India.
EM avishek.dbs@presiuniv.ac.in
RI Mondal, Anupam/NDS-7145-2025; BAG, SAGAR/ABK-9777-2022; Banik,
   Avishek/H-5072-2012
OI Bag, Sagar/0000-0002-9298-4697; , ANUPAM MONDAL/0009-0001-1056-2715;
   Majumder, Anusha/0000-0002-9719-3245; Banik, Avishek/0000-0001-5029-2708
FU Science and Engineering Research Board (SERB) [SRG/2020/000586];
   Department of Science and Technology, Government of India
FX Science and Engineering Research Board (SERB) (Project File No.
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NR 114
TC 100
Z9 104
U1 11
U2 161
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0308-8146
EI 1873-7072
J9 FOOD CHEM
JI Food Chem.
PD MAR 1
PY 2022
VL 371
AR 131098
DI 10.1016/j.foodchem.2021.131098
EA OCT 2021
PG 13
WC Chemistry, Applied; Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Food Science & Technology; Nutrition & Dietetics
GA WF5UX
UT WOS:000706370000002
PM 34634647
DA 2025-06-11
ER

PT J
AU Saidi, H
   Bounihi, A
   Bouazza, A
   Hichami, A
   Koceir, EA
   Khan, NA
AF Saidi, Hamza
   Bounihi, Abdenour
   Bouazza, Asma
   Hichami, Aziz
   Koceir, El Hadj Ahmed
   Khan, Naim Akhtar
TI Spirulina reduces diet-induced obesity through downregulation of
   lipogenic genes expression in Psammomys obesus
SO ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
LA English
DT Article
DE Spirulina; Psammomys obesus; lipogenesis; obesity; insulin-resistance
ID OXIDATIVE STRESS; C-PHYCOCYANIN; TRANSCRIPTION FACTOR;
   INSULIN-RESISTANCE; STEROL REGULATION; LIVER; INFLAMMATION; PLATENSIS;
   ADIPOSE; GLUCOSE
AB The present study evaluates the protective effect of spirulina against diet-induced obesity and metabolic disorders in Psammomys obesus, an animal model of metabolic syndrome. Psammomys obesus lives on a low-energy diet, in order to remain healthy. However, under a standard laboratory chow diet (SLCD), this animal exhibits insulin resistance, which occurs as a result of obesity. Psammomys obesus was maintained on SLCD, in order to evaluate the effect of spirulina on obesity development with a particular focus on glucose and lipid metabolism, as well as the mRNA expression of some pro-inflammatory cytokines. After 12 weeks of treatment with spirulina, there was a significant reduction in body weight gain, plasma glucose, insulin and triglyceride levels. There was also a significant reduction in the mRNA expression of genes involved in lipogenesis and inflammation. Spirulina improved insulin sensitivity, glucose and lipid metabolism. These findings highlight the positive effect of spirulina on weight maintenance.
C1 [Saidi, Hamza; Bounihi, Abdenour; Bouazza, Asma; Koceir, El Hadj Ahmed] Univ Sci & Technol Houari Boumediene, Bioenerget & Intermediary Metab Team, Lab Biol & Organism Physiol, Algiers, Algeria.
   [Hichami, Aziz; Khan, Naim Akhtar] Univ Burgundy Franche Comte, INSERM, U1231, Dijon, France.
C3 University Science & Technology Houari Boumediene; Institut Agro;
   AgroSup Dijon; Institut National de la Sante et de la Recherche Medicale
   (Inserm); Universite Bourgogne Europe
RP Saidi, H (corresponding author), Univ Sci & Technol Houari Boumediene, Bioenerget & Intermediary Metab Team, Lab Biol & Organism Physiol, Algiers, Algeria.
EM saidi.hamza.dz@gmail.com
RI Bounihi, Abdenour/ABF-7589-2021; SAIDI, Hamza/GLS-8192-2022; Hichami,
   Aziz/MCJ-2247-2025
OI SAIDI, Hamza/0000-0001-8340-995X; Khan, Naim Akhtar/0000-0002-8930-9332;
   BOUNIHI, Abdenour/0000-0001-7794-418X
FU Algerian Ministry of Higher Education AMP; Scientific Research programme
   [F 0022014 0100]
FX This work was supported by the Algerian Ministry of Higher Education &
   Scientific Research programme under grant [F 0022014 0100].
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NR 57
TC 6
Z9 6
U1 2
U2 12
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1381-3455
EI 1744-4160
J9 ARCH PHYSIOL BIOCHEM
JI Arch. Physiol. Biochem.
PD JUL 4
PY 2022
VL 128
IS 4
BP 1001
EP 1009
DI 10.1080/13813455.2020.1743724
EA MAR 2020
PG 9
WC Biochemistry & Molecular Biology; Biophysics; Endocrinology &
   Metabolism; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Endocrinology &
   Metabolism; Physiology
GA 3L5FL
UT WOS:000524070300001
PM 32207345
DA 2025-06-11
ER

PT J
AU Das, A
AF Das, Aniruddha
TI Chronic Ongoing Stressors and C-Reactive Protein: A Within-Person Study
SO JOURNAL OF AGING AND HEALTH
LA English
DT Article
DE stress process; cardiometabolic; inflammation; older adults; HRS
ID CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; SEX-DIFFERENCES;
   INFLAMMATORY BIOMARKERS; MODERATING ROLE; SELECTION BIAS; OLDER-ADULTS;
   ALL-CAUSE; HEALTH; RISK
AB Objectives: Literature suggests C-reactive protein (CRP)-as a marker of low-grade systemic inflammation-may mediate the linkage between chronic stressors and cardiometabolic conditions. Previous population-based reports are based on weak methodologies and may have yielded incorrect inferences. The current study examined linkages of within-person CRP variation with corresponding variation in stressor burdens. Method: Data were from the 2006, 2010, and 2014 waves of the U.S. Health and Retirement Study. Analysis was through unit fixed effects and first-difference estimators. Both gender-combined and gender-specific models were run. Results: In none of the analyses was CRP positively associated with chronic stressors. This was true among both genders, and in models of linear as well as nonlinear change. Results held in a series of separate robustness checks. Discussion: CRP may not mediate the social etiology of degenerative diseases. Population representative evidence of inflammation's role in these processes remains absent.
C1 [Das, Aniruddha] McGill Univ, Montreal, PQ, Canada.
C3 McGill University
RP Das, A (corresponding author), McGill Univ, Dept Sociol, Room 712,Leacock Bldg,855 Sherbrooke St West, Montreal, PQ H3A 2T7, Canada.
EM aniruddha.das@mcgill.ca
FU National Institute on Aging [NIA U01AG009740]; National Institute on
   Aging [U01AG009740] Funding Source: NIH RePORTER
FX The author thanks the editor and three anonymous reviewers for their
   thorough and insightful comments. The HRS (Health and Retirement Study)
   is sponsored by the National Institute on Aging (grant number NIA
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NR 83
TC 2
Z9 2
U1 0
U2 1
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0898-2643
EI 1552-6887
J9 J AGING HEALTH
JI J. Aging Health
PD AUG
PY 2020
VL 32
IS 7-8
BP 892
EP 903
AR UNSP 0898264319862419
DI 10.1177/0898264319862419
EA JUL 2019
PG 12
WC Gerontology; Health Policy & Services
WE Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Health Care Sciences & Services
GA OC8YF
UT WOS:000477382700001
PM 31315485
DA 2025-06-11
ER

PT J
AU Simmen, T
   Herrera-Cruz, MS
AF Simmen, Thomas
   Herrera-Cruz, Maria Sol
TI Plastic mitochondria-endoplasmic reticulum (ER) contacts use chaperones
   and tethers to mould their structure and signaling
SO CURRENT OPINION IN CELL BIOLOGY
LA English
DT Review
ID INOSITOL 1,4,5-TRISPHOSPHATE RECEPTORS; RAT-LIVER; PHOSPHOLIPID
   TRANSFER; ALZHEIMERS-DISEASE; MEMBRANE-FRACTION; LIPID-SYNTHESIS;
   QUALITY-CONTROL; CALCIUM; APOPTOSIS; PROTEIN
AB Mitochondria-endoplasmic reticulum (ER) contacts (MERCs), biochemically isolated as the mitochondria-associated membrane (MAM), were discovered on electron micrographs in the early 1950s. Since the 1990s, we know that the two organelles exchange lipids and Ca2+ ions at these membrane contacts. Already in the very first publication on this intracellular structure, the extreme plasticity of the structure was obvious. Recent progress has now confirmed that ER and mitochondria move closer to deepen physical contacts under conditions of ER stress, hypoxia, or short-term nutrient deprivation, while nutrient over-supply is one situation that lessens contacts. Signaling associated with these intracellular events moulds the contact site ultrastructure, in particular during autophagy, apoptosis and alterations of mitochondria metabolism. Tethering complexes, as well as key MAM proteins including chaperones of the ER and mitochondriacontrol the plasticity of MERC structures. It has become evident that altered MAM composition and changes in MAM plasticity are critical factors for the development of cancer, neurodegeneration and the metabolic syndrome.
C1 [Simmen, Thomas; Herrera-Cruz, Maria Sol] Univ Alberta, Fac Med & Dent, Dept Cell Biol, Edmonton, AB, Canada.
C3 University of Alberta
RP Simmen, T (corresponding author), Univ Alberta, Fac Med & Dent, Dept Cell Biol, Edmonton, AB, Canada.
EM Thomas.Simmen@ualberta.ca
OI Simmen, Thomas/0000-0002-2350-2965
FU NSERC [RGPIN-2015-04105]
FX Research in the Simmen lab on the topic at hand was funded by NSERC
   grant RGPIN-2015-04105.
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NR 103
TC 65
Z9 69
U1 1
U2 32
PU CURRENT BIOLOGY LTD
PI LONDON
PA 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND
SN 0955-0674
EI 1879-0410
J9 CURR OPIN CELL BIOL
JI Curr. Opin. Cell Biol.
PD AUG
PY 2018
VL 53
BP 61
EP 69
DI 10.1016/j.ceb.2018.04.014
PG 9
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA GS6RT
UT WOS:000443826800010
PM 29870872
DA 2025-06-11
ER

PT J
AU Abenavoli, L
   Milic, N
   Peta, V
   Alfieri, F
   De Lorenzo, A
   Bellentani, S
AF Abenavoli, Ludovico
   Milic, Natasa
   Peta, Valentina
   Alfieri, Francesco
   De Lorenzo, Antonino
   Bellentani, Stefano
TI Alimentary regimen in non-alcoholic fatty liver disease: Mediterranean
   diet
SO WORLD JOURNAL OF GASTROENTEROLOGY
LA English
DT Article
DE Non-alcoholic fatty liver disease; Non-alcoholic steatohepatitis;
   Insulin resistance; Nutrition; Mediterranean diet
ID HEPATIC INSULIN-RESISTANCE; LIFE-STYLE INTERVENTION; METABOLIC SYNDROME;
   RISK-FACTORS; WEIGHT-LOSS; CARDIOVASCULAR-DISEASE; OXIDATIVE-STRESS;
   CONTROLLED-TRIAL; IRON STORES; STEATOHEPATITIS
AB Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide. The mechanisms of the underlying disease development and progression are awaiting clarification. Insulin resistance and obesity-related inflammation status, among other possible genetic, dietary, and lifestyle factors, are thought to play the key role. There is no consensus concerning the pharmacological treatment. However, the dietary nutritional management to achieve weight loss is an essential component of any treatment strategy. On the basis of its components, the literature reports on the effectiveness of the Mediterranean diet in reducing cardio-vascular risk and in preventing major chronic diseases, including obesity and diabetes. New evidence supports the idea that the Mediterranean diet, associated with physical activity and cognitive behaviour therapy, may have an important role in the prevention and the treatment of NAFLD. (C) 2014 Baishideng Publishing Group Inc. All rights reserved.
C1 [Abenavoli, Ludovico; Peta, Valentina] Magna Graecia Univ Catanzaro, Dept Hlth Sci, I-88100 Catanzaro, Italy.
   [Milic, Natasa] Univ Novi Sad, Dept Pharm, Novi Sad 21000, Serbia.
   [Alfieri, Francesco] Univ MEIER, I-20124 Baranzate Di Bollate, MI, Italy.
   [De Lorenzo, Antonino] Univ Roma Tor Vergata, Dept Biomed & Prevent, Div Clin Nutr & Nutrigen, I-00133 Rome, Italy.
   [Bellentani, Stefano] Azienda USL Modena, Ramazzini Hosp, I-42100 Carpi, Modena, Italy.
C3 Magna Graecia University of Catanzaro; University of Novi Sad;
   University of Rome Tor Vergata
RP Abenavoli, L (corresponding author), Magna Graecia Univ Catanzaro, Dept Hlth Sci, Campus Germaneto,Viale Europa, I-88100 Catanzaro, Italy.
EM l.abenavoli@unicz.it
RI Bellentani, Stefano/L-3600-2019; Abenavoli, Ludovico/J-4394-2019
OI De Lorenzo, Antonino/0000-0001-6524-4493; Bellentani,
   Stefano/0000-0003-2836-8870; Milic, Natasa/0000-0002-8595-6065;
   MONTEBIANCO ABENAVOLI, Ludovico/0000-0002-5922-1524
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NR 82
TC 80
Z9 92
U1 2
U2 25
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 8226 REGENCY DR, PLEASANTON, CA 94588 USA
SN 1007-9327
EI 2219-2840
J9 WORLD J GASTROENTERO
JI World J. Gastroenterol.
PD DEC 7
PY 2014
VL 20
IS 45
BP 16831
EP 16840
DI 10.3748/wjg.v20.i45.16831
PG 10
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA AW1LK
UT WOS:000346050700004
PM 25492997
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Costa, ADSD
   Oliveira, ASDS
   Brito, AKD
   Lopes, LAR
   Primo, MGS
   Sales, ALDC
   dos Santos, MAP
   Barros, NVD
   de Moura, OF
   da Silva, JKM
   Moura, EID
   Lucarini, M
   Durazzo, A
   Arcanjo, DDR
   Martins, MDDE
AF Costa, Antonio Daniel Saraiva da
   Oliveira, Amanda Suellenn da Silva Santos
   Brito, Ana Karolinne da Silva
   Lopes, Lays Arnaud Rosal
   Primo, Maisa Guimaraes Silva
   Sales, Ana Lina de Carvalho Cunha
   dos Santos, Marcos Antonio Pereira
   Barros, Nara Vanessa dos Anjos
   de Moura-Filho, Oseas Florencio
   da Silva, Jaynara Keylla Moreira
   Moura, Edwiges Ita de Miranda
   Lucarini, Massimo
   Durazzo, Alessandra
   Arcanjo, Daniel Dias Rufino
   Martins, Maria do Carmo de Carvalho e
TI Cryolipolysis on More than One Body Area Increases Lipid Peroxidation
   without Changing Lipid Profile and Inflammatory Markers
SO BIOLOGY-BASEL
LA English
DT Article
DE cryolipolysis; oxidative stress; inflammation; body composition;
   subcutaneous fat; adipose tissue
ID NONINVASIVE FAT REDUCTION; VISCERAL ADIPOSE-TISSUE; OBESITY; PLASMA;
   QUANTIFICATION; MECHANISMS; EXERCISE; DENSITY
AB Simple Summary Cryolipolysis is a technique based on reduction of skin temperature, leading to local or systemic exposure of subcutaneous adipose tissue to active cooling, which are able to cause possible inflammatory and oxidative stress repercussions. In the present study, cyolipolysis in adult women did not change body composition, lipid profile or inflammatory markers; when applied on the abdomen and flanks, this procedure led to an isolated increase in lipid peroxidation markers. Besides no cardiometabolic risk using this procedure was observed. In the present study, the effects of cryolipolysis on one and multiple body areas, assessing body composition, lipid profile and peroxidation and inflammatory markers were investigated. Twenty-four women aged between 20 and 59 years were randomly assigned to three groups: (1) control, (2) cryolipolysis on the abdomen and (3) cryolipolysis on the abdomen + flanks. Anthropometric measurements, bioimpedance and ultrasound were performed, as well serum lipid profile, lipid peroxidation markers (malondialdehyde and myeloperoxidase) and inflammatory markers (C-reactive protein and Interleukin-1 beta) were determined. In addition, food consumption and physical activity level were evaluated. Data were obtained at 0, 10 and 30 days (t0, t10 and t30) after cryolipolysis. Cryolipolysis did not change anthropometric measurements, body composition or lipid profile. Interestingly, the abdomen + flanks group had significantly increased plasma myeloperoxidase activity at t0, t10 and t30, and increased malondialdehyde levels at t0 and t10 when compared to the other groups. Furthermore, there were no differences between macronutrient intake and total energy value, physical activity level, malondialdehyde and interleukin-1 beta at t30. Cryolipolysis did not change body composition, lipid profile or inflammatory markers investigated. On the other hand, when used on the abdomen and flanks, it produced an increase in lipid peroxidation markers, malondialdehyde and myeloperoxidase.
C1 [Costa, Antonio Daniel Saraiva da; Oliveira, Amanda Suellenn da Silva Santos; Lopes, Lays Arnaud Rosal; Primo, Maisa Guimaraes Silva; Sales, Ana Lina de Carvalho Cunha] Univ Fed Piaui, Postgrad Program Food & Nutr, BR-64049550 Teresina, Brazil.
   [Brito, Ana Karolinne da Silva; dos Santos, Marcos Antonio Pereira; da Silva, Jaynara Keylla Moreira; Arcanjo, Daniel Dias Rufino; Martins, Maria do Carmo de Carvalho e] Univ Fed Piaui, Dept Biophys & Physiol, BR-64049550 Teresina, Brazil.
   [Barros, Nara Vanessa dos Anjos] Univ Fed Piaui, Campus Helvidio Nunes Barros CSHNB, BR-64607670 Picos, Brazil.
   [de Moura-Filho, Oseas Florencio] Inst Teaching & Res Clin Physiotherapy, BR-64049550 Teresina, Brazil.
   [Moura, Edwiges Ita de Miranda] GMI, MedImagem Grp, BR-64049550 Teresina, Brazil.
   [Lucarini, Massimo; Durazzo, Alessandra] CREA Res Ctr Food & Nutr, Via Ardeatina 546, I-00178 Rome, Italy.
C3 Universidade Federal do Piaui; Universidade Federal do Piaui;
   Universidade Federal do Piaui; Consiglio per la Ricerca in Agricoltura e
   L'analisi Dell'economia Agraria (CREA)
RP Martins, MDDE (corresponding author), Univ Fed Piaui, Dept Biophys & Physiol, BR-64049550 Teresina, Brazil.
EM carminhamartins@ufpi.edu.br
RI Durazzo, Alessandra/AAN-4182-2020; Martins, MARIA DO CARMO DE CARVALHO
   E/AAK-9854-2020; Brito, Ana/LKK-0208-2024; Oliveira,
   Amanda/KQV-4706-2024; Lucarini, Massimo/AAL-9254-2020; dos santos,
   marcos antonio/J-5016-2016; Arcanjo, Daniel/D-8851-2012
OI Martins, Maria do Carmo de Carvalho e/0000-0002-9107-2485; Arcanjo,
   Daniel/0000-0001-7021-2744; Santos, Marcos Antonio Pereira
   dos/0000-0002-0755-6138; Oliveira, Amanda Livia/0009-0008-2075-9985;
   Durazzo, Alessandra/0000-0002-7747-9107; da Silva Brito, Ana
   Karolinne/0000-0002-9575-2103; Arnaud Rosal Lopes Rodrigues,
   Lays/0000-0002-6329-8380
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NR 71
TC 1
Z9 1
U1 0
U2 2
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2079-7737
J9 BIOLOGY-BASEL
JI Biology-Basel
PD DEC
PY 2022
VL 11
IS 12
AR 1690
DI 10.3390/biology11121690
PG 14
WC Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics
GA 7G1VN
UT WOS:000902321200001
PM 36552200
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Connolly, BJ
   Saxton, SN
AF Connolly, Benjamin J.
   Saxton, Sophie N.
TI Recent updates on the influence of iron and magnesium on vascular,
   renal, and adipose inflammation and possible consequences for
   hypertension
SO JOURNAL OF HYPERTENSION
LA English
DT Article
DE adipose; hypertension; inflammation; iron; kidney; magnesium;
   micronutrient; obesity; renal; vascular
ID FATTY LIVER-DISEASE; INSULIN-RESISTANCE; OXIDATIVE STRESS;
   BLOOD-PRESSURE; ENDOTHELIAL FUNCTION; METABOLIC SYNDROME;
   ANTIINFLAMMATORY DRUGS; DENDRITIC CELLS; IMMUNE CELLS; T-CELLS
AB The inflammatory status of the kidneys, vasculature, and perivascular adipose tissue (PVAT) has a significant influence on blood pressure and hypertension. Numerous micronutrients play an influential role in hypertension-driving inflammatory processes, and recent reports have provided bases for potential targeted modulation of these micronutrients to reduce hypertension. Iron overload in adipose tissue macrophages and adipocytes engenders an inflammatory environment and may contribute to impaired anticontractile signalling, and thus a treatment such as chelation therapy may hold a key to reducing blood pressure. Similarly, magnesium intake has proven to greatly influence inflammatory signalling and concurrent hypertension in both healthy animals and in a model for chronic kidney disease, demonstrating its potential clinical utility. These findings highlight the importance of further research to determine the efficacy of micronutrient-targeted treatments for the amelioration of hypertension and their potential translation into clinical application.
C1 [Connolly, Benjamin J.; Saxton, Sophie N.] Univ Manchester, Div Cardiovasc Sci, Manchester, England.
C3 University of Manchester
RP Saxton, SN (corresponding author), Div Cardiovasc Sci, Core Technol Facil, 3rd Floor,46 Grafton St, Manchester M13 9NT, England.
EM sophie.saxton@manchester.ac.uk
FU British Heart Foundation [AA/18/4/342, PG/22/11044]
FX British Heart Foundation AA/18/4/342 and PG/22/11044.
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NR 145
TC 0
Z9 0
U1 2
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0263-6352
EI 1473-5598
J9 J HYPERTENS
JI J. Hypertens.
PD NOV
PY 2024
VL 42
IS 11
BP 1848
EP 1861
DI 10.1097/HJH.0000000000003829
PG 14
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA I2A8G
UT WOS:001328342000004
PM 39258532
DA 2025-06-11
ER

PT J
AU Ramatchandirin, B
   Pearah, A
   He, L
AF Ramatchandirin, Balamurugan
   Pearah, Alexia
   He, Ling
TI Regulation of Liver Glucose and Lipid Metabolism by Transcriptional
   Factors and Coactivators
SO LIFE-BASEL
LA English
DT Review
DE fatty liver; obesity; type 2 diabetes
ID ELEMENT-BINDING PROTEIN; PROLIFERATOR-ACTIVATED RECEPTORS;
   ENDOPLASMIC-RETICULUM STRESS; TYPE-2 DIABETES-MELLITUS; FATTY LIVER;
   INSULIN-RESISTANCE; HEPATIC GLUCONEOGENESIS; PPAR-GAMMA;
   GENE-EXPRESSION; MESSENGER-RNA
AB The prevalence of nonalcoholic fatty liver disease (NAFLD) worldwide is on the rise and NAFLD is becoming the most common cause of chronic liver disease. In the USA, NAFLD affects over 30% of the population, with similar occurrence rates reported from Europe and Asia. This is due to the global increase in obesity and type 2 diabetes mellitus (T2DM) because patients with obesity and T2DM commonly have NAFLD, and patients with NAFLD are often obese and have T2DM with insulin resistance and dyslipidemia as well as hypertriglyceridemia. Excessive accumulation of triglycerides is a hallmark of NAFLD and NAFLD is now recognized as the liver disease component of metabolic syndrome. Liver glucose and lipid metabolisms are intertwined and carbon flux can be used to generate glucose or lipids; therefore, in this review we discuss the important transcription factors and coactivators that regulate glucose and lipid metabolism.
C1 [Ramatchandirin, Balamurugan; Pearah, Alexia; He, Ling] Johns Hopkins Univ, Dept Pediat, Sch Med, Baltimore, MD 21287 USA.
   [He, Ling] Johns Hopkins Univ, Dept Pharmacol & Mol Sci, Sch Med, 600 N Wolfe St, Baltimore, MD 21287 USA.
C3 Johns Hopkins University; Johns Hopkins University
RP He, L (corresponding author), Johns Hopkins Univ, Dept Pediat, Sch Med, Baltimore, MD 21287 USA.; He, L (corresponding author), Johns Hopkins Univ, Dept Pharmacol & Mol Sci, Sch Med, 600 N Wolfe St, Baltimore, MD 21287 USA.
EM heling@jhmi.edu
RI Ramatchandirin, Balamurugan/AAB-7958-2020
OI Ramatchandirin, Dr. Balamurugan/0000-0003-0390-1878
FU National Institute of Diabetes and Digestive and Kidney Diseases
   [R01DK120309, R01DK107641]
FX This work was supported in part by grants from the National Institute of
   Diabetes and Digestive and Kidney Diseases: R01DK120309 and R01DK107641.
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NR 198
TC 6
Z9 8
U1 0
U2 15
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2075-1729
J9 LIFE-BASEL
JI Life-Basel
PD FEB
PY 2023
VL 13
IS 2
AR 515
DI 10.3390/life13020515
PG 23
WC Biology; Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics; Microbiology
GA 9J8GL
UT WOS:000940418100001
PM 36836874
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Wang, MD
   Liang, Y
   Chen, KQ
   Wang, ML
   Long, XH
   Liu, HL
   Sun, Y
   He, B
AF Wang, Mengdi
   Liang, Yan
   Chen, Keqi
   Wang, Maolong
   Long, Xuehua
   Liu, HongLing
   Sun, Yong
   He, Bin
TI The management of diabetes mellitus by mangiferin: advances and
   prospects
SO NANOSCALE
LA English
DT Review
ID NF-KAPPA-B; ENDOPLASMIC-RETICULUM STRESS; BETA-CELL REGENERATION;
   INSULIN-RESISTANCE; NEPHROPATHY PROGRESSION; ORAL DELIVERY; GREEN
   NANOTECHNOLOGY; EUROPEAN ASSOCIATION; AYURVEDIC MEDICINE; METABOLIC
   SYNDROME
AB Diabetes mellitus has become one of the most challenging public health problems today. There are still various deficiencies that remain in existing therapeutic drugs. With increasing prevalence and mortality rates, more effective therapeutic agents are required for treatment clinically. As a kind of polyphenol and as a natural product, mangiferin has numerous pharmacological and excellent effects. In this review, the underlying mechanisms of mangiferin on diabetes mellitus and complications will be summarized. Moreover, mangiferin belongs to the BSC IV class and the clinical application and development of mangiferin are limited due to its poor aqueous solubility and fat solubility as well as low bioavailability. Our review also elaborated on improving the solubility of mangiferin by changing the dosage form and introduced the existing results, which hope to provide useful reference for mangiferin for further treating diabetes. In conclusion, mangiferin might be a potential adjuvant therapy for the treatment of diabetes mellitus and complications in the future.
C1 [Wang, Mengdi; Liang, Yan; Long, Xuehua; Sun, Yong] Qingdao Univ, Sch Pharm, Dept Pharmaceut, Qingdao 266073, Peoples R China.
   [Chen, Keqi] Qingdao Special Servicemen Recuperat Ctr PLA Navy, Dept Clin Lab, Qingdao 266021, Peoples R China.
   [Wang, Maolong] Qingdao Univ, Dept Thorac Surg, Affiliated Hosp, Qingdao 266000, Peoples R China.
   [Liu, HongLing] Qingdao Univ, Dept Pharm, Affiliated Hosp, Qingdao 266000, Peoples R China.
   [He, Bin] Sichuan Univ, Natl Engn Res Ctr Biomat, Chengdu 610064, Peoples R China.
C3 Qingdao University; Qingdao University; Qingdao University; Sichuan
   University
RP Sun, Y (corresponding author), Qingdao Univ, Sch Pharm, Dept Pharmaceut, Qingdao 266073, Peoples R China.; Liu, HL (corresponding author), Qingdao Univ, Dept Pharm, Affiliated Hosp, Qingdao 266000, Peoples R China.
EM lhl3798@126.com; sunyong@qdu.edu.cn
RI chen, keqi/KXR-0711-2024; he, bin/AAV-6319-2021; Liang,
   Yan/KQV-2687-2024; He, Bin/B-3257-2015
OI Sun, Yong/0000-0003-0365-1151; Liang, Yan/0000-0003-1084-6117; He,
   Bin/0000-0002-0939-9869
FU China Postdoctoral Natural Science Foundation [2017M622134, 2018M632612,
   2021TQ0160]; Qingdao Science and Technology Demonstration and Guidance
   Project [21-1-4-rkjk-10-nsh]; Scientific Research Foundation for Youth
   Scholars from Qingdao University [41117010022]
FX The authors thank for the financial support of China Postdoctoral
   Natural Science Foundation (No. 2017M622134, 2018M632612 and
   2021TQ0160), Qingdao Science and Technology Demonstration and Guidance
   Project (21-1-4-rkjk-10-nsh), and Scientific Research Foundation for
   Youth Scholars from Qingdao University (No. 41117010022).
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NR 139
TC 31
Z9 34
U1 5
U2 50
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2040-3364
EI 2040-3372
J9 NANOSCALE
JI Nanoscale
PD FEB 10
PY 2022
VL 14
IS 6
BP 2119
EP 2135
DI 10.1039/d1nr06690k
EA DEC 2021
PG 17
WC Chemistry, Multidisciplinary; Nanoscience & Nanotechnology; Materials
   Science, Multidisciplinary; Physics, Applied
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Science & Technology - Other Topics; Materials Science;
   Physics
GA YW7GL
UT WOS:000750983000001
PM 35088781
DA 2025-06-11
ER

PT J
AU Ozcan, L
   de Souza, JC
   Harari, AA
   Backs, J
   Olson, EN
   Tabas, I
AF Ozcan, Lale
   de Souza, Jane Cristina
   Harari, Alp Avi
   Backs, Johannes
   Olson, Eric N.
   Tabas, Ira
TI Activation of Calcium/Calmodulin- Dependent Protein Kinase II in Obesity
   Mediates Suppression of Hepatic Insulin Signaling
SO CELL METABOLISM
LA English
DT Article
ID ENDOPLASMIC-RETICULUM STRESS; GLUCOSE-PRODUCTION; LIPID-METABOLISM;
   TRIBBLES HOMOLOG; SKELETAL-MUSCLE; TRB3 EXPRESSION; RESISTANCE; LIVER;
   MICE; PHOSPHORYLATION
AB A hallmark of obesity is selective suppression of hepatic insulin signaling ("insulin resistance"), but critical gaps remain in our understanding of the molecular mechanisms. We now report a major role for hepatic CaMKII, a calcium-responsive kinase that is activated in obesity. Genetic targeting of hepatic CaMKII, its downstream mediator p38, or the p38 substrate and stabilizer MK2 enhances insulin-induced p-Akt in palmitate-treated hepatocytes and obese mouse liver, leading to metabolic improvement. The mechanism of improvement begins with induction of ATF6 and the ATF6 target p58 IPK, a chaperone that suppresses the PERK-p-eIF2 alpha-ATF4 branch of the UPR. The result is a decrease in the ATF4 target TRB3, an inhibitor of insulin-induced p-Akt, leading to enhanced activation of Akt and its downstream metabolic mediators. These findings increase our understanding of the molecular mechanisms linking obesity to selective insulin resistance and suggest new therapeutic targets for type 2 diabetes and metabolic syndrome.
C1 [Ozcan, Lale; de Souza, Jane Cristina; Harari, Alp Avi; Tabas, Ira] Columbia Univ, Dept Med, New York, NY 10032 USA.
   [Tabas, Ira] Columbia Univ, Dept Physiol & Cellular Biophys, New York, NY 10032 USA.
   [Tabas, Ira] Columbia Univ, Dept Pathol & Cell Biol, New York, NY 10032 USA.
   [Backs, Johannes] Heidelberg Univ, Dept Cardiol, Lab Cardiac Epigenet, D-69120 Heidelberg, Germany.
   [Backs, Johannes] DZHK German Ctr Cardiovasc Res, D-69120 Heidelberg, Germany.
   [Olson, Eric N.] Univ Texas SW Med Ctr Dallas, Dept Mol Biol, Dallas, TX 75390 USA.
C3 Columbia University; Columbia University; Columbia University; Ruprecht
   Karls University Heidelberg; German Centre for Cardiovascular Research;
   University of Texas System; University of Texas Southwestern Medical
   Center Dallas
RP Ozcan, L (corresponding author), Columbia Univ, Dept Med, New York, NY 10032 USA.
EM lo2192@columbia.edu; iat1@columbia.edu
RI Olson, Eric/B-4391-2013; souza, jane/I-5779-2012
OI Olson, Eric N./0000-0003-1151-8262; Ozcan, Lale/0000-0002-2710-7057;
   Tabas, Ira/0000-0003-3429-1515
FU American Heart Association Scientist Development Grant [11SDG5300022];
   NYONRC Pilot and Feasibility Grant [DK26687]; FAPESP/BEPE
   [2012/21290-4]; DZHK (German Centre for Cardiovascular Research); BMBF
   (German Ministry of Education and Research); DFG (Deutsche
   Forschungsgemeinschaft) [BA 2258/2-1]; European Commission (FP7-Health)
   [MEDIA-261409]; NIH [HL087123, HL075662]; Fundacao de Amparo a Pesquisa
   do Estado de Sao Paulo (FAPESP) [12/21290-4] Funding Source: FAPESP;
   American Heart Association (AHA) [11SDG5300022] Funding Source: American
   Heart Association (AHA)
FX We thank Dr. Harold A. Singer (Albany Medical College) for adeno-LacZ,
   T287D-CaMKII, and K43A-CaMKII; Dr. Marc Montminy (Salk Institute for
   Biological Studies) for adeno-TRB3 and adeno-TRB3 RNAi; Randal J.
   Kaufman (Sanford-Burnham Medical Research Institute) for adeno-ATF4; and
   Dr. Domenico Accili (Columbia University) for adeno-FoxO1-ADA. This work
   was supported by an American Heart Association Scientist Development
   Grant (11SDG5300022) and a NYONRC Pilot and Feasibility Grant (DK26687)
   to L.O.; by FAPESP/BEPE 2012/21290-4 to J. C. S.; by the DZHK (German
   Centre for Cardiovascular Research), BMBF (German Ministry of Education
   and Research), DFG (Deutsche Forschungsgemeinschaft; BA 2258/2-1), and
   the European Commission (FP7-Health-2010; MEDIA-261409) to J. B.; and by
   NIH grants HL087123 and HL075662 to I. T. Authors L.O. and I. T. are in
   the group of cofounders of Tabomedex Biosciences LLC, which is
   developing inhibitors of the pathway described in this report for
   treatment of type 2 diabetes.
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NR 46
TC 112
Z9 127
U1 0
U2 11
PU CELL PRESS
PI CAMBRIDGE
PA 600 TECHNOLOGY SQUARE, 5TH FLOOR, CAMBRIDGE, MA 02139 USA
SN 1550-4131
EI 1932-7420
J9 CELL METAB
JI Cell Metab.
PD DEC 3
PY 2013
VL 18
IS 6
BP 803
EP 815
DI 10.1016/j.cmet.2013.10.011
PG 13
WC Cell Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Endocrinology & Metabolism
GA 265HJ
UT WOS:000327940800007
PM 24268736
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Cowan, AQ
   Cho, DJ
   Rosenson, RS
AF Cowan, Aimee Q.
   Cho, Daniel J.
   Rosenson, Robert S.
TI Importance of Blood Rheology in the Pathophysiology of Atherothrombosis
SO CARDIOVASCULAR DRUGS AND THERAPY
LA English
DT Article
DE Whole blood viscosity; Rheology; Hemorheology; Atherothrombosis
ID HIGH-DENSITY-LIPOPROTEIN; HEMOSTATIC RISK-FACTORS;
   CORONARY-HEART-DISEASE; PLASMA VISCOSITY; EDINBURGH ARTERY;
   CARDIOVASCULAR-DISEASES; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   CIGARETTE-SMOKING; MONICA PROJECT
AB Elevated blood viscosity is an integral component of vascular shear stress that contributes to the site specificity of atherogenesis, rapid growth of atherosclerotic lesions, and increases their propensity to rupture. Ex vivo measurements of whole blood viscosity (WBV) is a predictor of cardiovascular events in apparently healthy individuals and studies of cardiovascular disease patients. The association of an elevated WBV and incident cardiovascular events remains significant in multivariate models that adjust for major cardiovascular risk factors. These prospective data suggest that measurement of WBV may be valuable as part of routine cardiovascular profiling, thereby potentially useful data for risk stratification and therapeutic interventions. The recent development of a high throughput blood viscometer, which is capable of rapidly performing blood viscosity measurements across 10,000 shear rates using a single blood sample, enables the assessment of blood flow characteristics in different regions of the circulatory system and opens new opportunities for detecting and monitoring cardiovascular diseases.
C1 [Cowan, Aimee Q.; Rosenson, Robert S.] Mt Sinai Sch Med, New York, NY 10029 USA.
   [Cho, Daniel J.] Rheovector LLC, Pennsauken, NJ USA.
C3 Icahn School of Medicine at Mount Sinai
RP Rosenson, RS (corresponding author), Mt Sinai Sch Med, Box 1030, New York, NY 10029 USA.
EM robert.rosenson@mssm.edu
RI Rosenson, Robert/MDS-6957-2025
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NR 66
TC 69
Z9 74
U1 4
U2 25
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0920-3206
J9 CARDIOVASC DRUG THER
JI Cardiovasc. Drugs Ther.
PD AUG
PY 2012
VL 26
IS 4
BP 339
EP 348
DI 10.1007/s10557-012-6402-4
PG 10
WC Cardiac & Cardiovascular Systems; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Pharmacology & Pharmacy
GA 985HY
UT WOS:000307255200009
PM 22821616
DA 2025-06-11
ER

PT J
AU Shah, TJ
   Leik, CE
   Walsh, SW
AF Shah, Tanvi J.
   Leik, Courtney E.
   Walsh, Scott W.
TI Neutrophil Infiltration and Systemic Vascular Inflammation in Obese
   Women
SO REPRODUCTIVE SCIENCES
LA English
DT Article
DE Obesity; neutrophils; inflammation; hypertension; cyclooxygenase-2;
   nuclear factor-kappa B
ID C-REACTIVE PROTEIN; OXIDATIVE STRESS; INSULIN-RESISTANCE; METABOLIC
   SYNDROME; RISK; KINASE; MASS; INTERLEUKIN-6; PREECLAMPSIA; HYPERTENSION
AB Obesity has become epidemic worldwide and is especially pronounced in women of reproductive age, which is important because obesity is a major risk factor for preeclampsia and chronic hypertension. We hypothesized that vascular inflammation is critical to the pathophysiology of hypertension in obese individuals because obesity and hypertensive disorders share common features related to inflammation. To study this, we collected subcutaneous fat biopsies from normal weight, overweight, and obese women and stained the tissues for CD66b, a neutrophil marker, and for activated nuclear factor-kappa B (NF-kappa B) and cyclooxygenase-2 (COX-2) as markers of inflammation. We found that the number of neutrophils per vessel and the percentage and intensity Of vessel staining for CD66b, NF-kappa B and COX-2 were greatest in obese women and least in normal weight women, and that neutrophil infiltration and vascular inflammation significantly correlated with body mass index (BMI) and blood pressure. These data may help explain the relationship between obesity and hypertensive disorders.
C1 [Walsh, Scott W.] Virginia Commonwealth Univ, Dept Obstet & Gynecol, Med Ctr, Richmond, VA 23298 USA.
   Virginia Commonwealth Univ, Dept Physiol & Biophys, Richmond, VA 23298 USA.
C3 Virginia Commonwealth University; Virginia Commonwealth University
RP Walsh, SW (corresponding author), Virginia Commonwealth Univ, Dept Obstet & Gynecol, Med Ctr, POB 980034, Richmond, VA 23298 USA.
EM swwalsh@vcu.edu
RI Stefanadis, Christodoulos/ABH-2232-2020
OI Stefanadis, Christodoulos/0000-0001-5974-6454
FU National Institutes of Health [HL069851]
FX Supported by a grant to SWW from the National Institutes of Health
   (HL069851)
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NR 28
TC 69
Z9 82
U1 0
U2 3
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1933-7191
EI 1933-7205
J9 REPROD SCI
JI Reprod. Sci.
PD FEB
PY 2010
VL 17
IS 2
BP 116
EP 124
DI 10.1177/1933719109348252
PG 9
WC Obstetrics & Gynecology; Reproductive Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology; Reproductive Biology
GA 545SL
UT WOS:000273757000003
PM 19820230
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Puddey, IB
   Mori, TA
   Barden, AE
   Beilin, LJ
AF Puddey, Ian B.
   Mori, Trevor A.
   Barden, Anne E.
   Beilin, Lawrence J.
TI Alcohol and Hypertension-New Insights and Lingering Controversies
SO CURRENT HYPERTENSION REPORTS
LA English
DT Review
DE Alcohol; Blood pressure; Hypertension
ID CARDIOVASCULAR RISK-FACTORS; AMBULATORY BLOOD-PRESSURE; MASKED
   HYPERTENSION; METABOLIC SYNDROME; ENDOTHELIAL FUNCTION; BRIEF
   INTERVENTION; CYTOCHROME-P450 EICOSANOIDS; INFLAMMATION RESOLUTION;
   GENERAL-POPULATION; RANDOMIZED-TRIAL
AB Purpose of Review To examine outstanding issues in the relationship of alcohol to hypertension. These include whether the increase in BP with alcohol is causally related, the nature of the relationship in women, the contribution of alcohol-related increases in BP to cardiovascular disease and the aetiology of alcohol-related hypertension. Recent Findings Intervention studies and Mendelian randomisation analyses confirm the alcohol-BP relationship is causal. The concept that low-level alcohol intake reduces BP in women is increasingly unsustainable. Alcohol-related hypertension is in the causal pathway between alcohol use and increased risk for several cardiovascular outcomes. The aetiology of alcohol-related hypertension is multifactorial with recent data highlighting the effects of alcohol on the vasoconstrictor 20-HETE and oxidative stress. The high prevalence of both alcohol use and hypertension mandates a careful alcohol history in every patient with elevated BP. Early intervention for excessive alcohol use offers the promise of lower levels of BP and reduced risk of adverse cardiovascular outcomes.
C1 [Puddey, Ian B.; Mori, Trevor A.; Barden, Anne E.; Beilin, Lawrence J.] Univ Western Australia, Sch Med, Fac Med & Hlth Sci, Royal Perth Hosp Unit, POB X2213, Perth, WA 6847, Australia.
C3 East Metropolitan Health Service; Royal Perth Hospital; University of
   Western Australia
RP Puddey, IB (corresponding author), Univ Western Australia, Sch Med, Fac Med & Hlth Sci, Royal Perth Hosp Unit, POB X2213, Perth, WA 6847, Australia.
EM Ian.Puddey@uwa.edu.au
RI Beilin, L./I-9182-2019; Puddey, Ian/H-5673-2014; Mori,
   Trevor/H-5485-2014
OI Barden, Anne/0000-0001-7631-0767; Mori, Trevor A/0000-0002-5264-9229;
   Beilin, Lawrence/0000-0003-4853-7360
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NR 90
TC 61
Z9 69
U1 4
U2 48
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1522-6417
EI 1534-3111
J9 CURR HYPERTENS REP
JI Curr. Hypertens. Rep.
PD OCT
PY 2019
VL 21
IS 10
AR 79
DI 10.1007/s11906-019-0984-1
PG 10
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Cardiovascular System & Cardiology
GA IV9DA
UT WOS:000484562900001
PM 31494743
DA 2025-06-11
ER

PT J
AU Yamamoto, K
   Kuragano, T
   Kimura, T
   Nanami, M
   Hasuike, Y
   Nakanishi, T
AF Yamamoto, Kiyoko
   Kuragano, Takahiro
   Kimura, Tomoko
   Nanami, Masayoshi
   Hasuike, Yukiko
   Nakanishi, Takeshi
TI Interplay of adipocyte and hepatocyte: Leptin upregulates hepcidin
SO BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
LA English
DT Article
DE Hepcidin; Leptin; Metabolic syndrome; Iron dysregulation
ID SKELETAL-MUSCLE; OBESE CHILDREN; IRON; EXPRESSION; ATHEROSCLEROSIS;
   ASSOCIATION; HOMEOSTASIS; MYONECTIN; INCREASES
AB Conflicting evidence concerning leptin, an adipocyte-derived hormone, in atherogenesis and nonalcoholic fatty liver disease (NAFLD) has been reported. Iron metabolism and iron-mediated oxidative stress should be taken into consideration for the clarification of the pathogenesis of these diseases. In this study, we demonstrate that leptin receptor activation directly affects iron metabolism by the finding that serum levels of hepcidin, the master regulator of iron in the whole body, were significantly lower in leptin-deficient (ob/ob) and leptin receptor-deficient (db/db) mice. The administration of recombinant leptin to ob/ob mice for two weeks showed a significant increase in serum hepcidin and hepatic Hamp mRNA levels. Hamp mRNA levels were significantly correlated with hepatic iron content and BMP6 mRNA levels. Hepatic iron content was associated with the increase in mRNA levels of divalent metal transporter 1 and transferrin receptor. Our data provide evidence that the interplay of these two hormones could help improve the understanding of the pathogenesis of atherosclerosis and NAFLD. (C) 2017 Elsevier Inc. All rights reserved.
C1 [Yamamoto, Kiyoko; Kuragano, Takahiro; Kimura, Tomoko; Nanami, Masayoshi; Hasuike, Yukiko; Nakanishi, Takeshi] Hyogo Coll Med, Div Kidney & Dialysis, Dept Internal Med, 1-1 Mukogawa Cho, Nishinomiya, Hyogo 6638501, Japan.
C3 Hyogo Medical University
RP Kuragano, T (corresponding author), Hyogo Coll Med, Div Kidney & Dialysis, Dept Internal Med, 1-1 Mukogawa Cho, Nishinomiya, Hyogo 6638501, Japan.
EM kuragano@hyo-med.ac.jp
OI Kimura, Tomoko/0000-0001-9887-6649
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NR 28
TC 26
Z9 27
U1 0
U2 5
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0006-291X
EI 1090-2104
J9 BIOCHEM BIOPH RES CO
JI Biochem. Biophys. Res. Commun.
PD JAN 1
PY 2018
VL 495
IS 1
BP 1548
EP 1554
DI 10.1016/j.bbrc.2017.11.103
PG 7
WC Biochemistry & Molecular Biology; Biophysics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics
GA FU5MM
UT WOS:000423897600231
PM 29158088
DA 2025-06-11
ER

PT J
AU Wainwright, P
   Scorletti, E
   Byrne, CD
AF Wainwright, P.
   Scorletti, E.
   Byrne, C. D.
TI Type 2 Diabetes and Hepatocellular Carcinoma: Risk Factors and
   Pathogenesis
SO CURRENT DIABETES REPORTS
LA English
DT Review
DE Diabetes; Obesity; Hepatocellular carcinoma; Risk factors; Pathogenesis;
   Non-alcoholic fatty liver disease
ID FATTY LIVER-DISEASE; LIPID-PEROXIDATION PRODUCT; NONALCOHOLIC
   STEATOHEPATITIS; INSULIN-RESISTANCE; HEPATITIS-C; MITOCHONDRIAL
   DYSFUNCTION; EPIDEMIOLOGIC EVIDENCE; ABDOMINAL OBESITY; UNITED-STATES;
   CANCER
AB Purpose of Review This review aims to assess the epidemiological evidence for a link between type 2 diabetes and hepatocellular carcinoma and to investigate possible pathophysiological mechanisms.
   Recent Findings The presence of type 2 diabetes significantly increases the risk of developing hepatocellular carcinoma, and treatment with metformin may be associated with a lower risk. Treatment with insulin and sulphonylureas may be associated with increased risk. The pathophysiology underlying development of hepatocellular carcinoma in this context is complex and is likely to involve increased proinflammatory mediators, oxidative stress, JNK-1 activation, increased IGF-1 activity, altered gut microbiota and immunomodulation.
   Summary Hepatocellular carcinoma incidence is increasing and this is likely to be linked to the increasing incidence of type 2 diabetes, obesity and the metabolic syndrome. These conditions increase the risk of developing hepatocellular carcinoma, and a greater understanding of the underlying pathophysiology may help with the development of novel treatments.
C1 [Wainwright, P.] Southampton Univ Hosp, Clin Biochem, Southampton, Hants, England.
   [Wainwright, P.] Southampton Univ Hosp, Dept Lab Med, Chem Pathol & Metab Med, D Level Pathol Block, Tremona Rd, Southampton SO16 6YD, Hants, England.
   [Scorletti, E.; Byrne, C. D.] Univ Southampton, Fac Med, Human Dev & Hlth Acad Unit, Southampton, Hants, England.
   [Scorletti, E.; Byrne, C. D.] Univ Southampton, Natl Inst Hlth Res Southampton, Biomed Res Ctr Nutr, Southampton, Hants, England.
   [Scorletti, E.; Byrne, C. D.] Univ Southampton, Natl Inst Hlth Res Southampton, Resp Biomed Res Unit, Southampton, Hants, England.
   [Scorletti, E.; Byrne, C. D.] Southampton Univ Hosp, NHS Fdn Trust, Southampton, Hants, England.
C3 University of Southampton; University of Southampton; University of
   Southampton; University of Southampton; University of Southampton;
   University of Southampton
RP Wainwright, P (corresponding author), Southampton Univ Hosp, Clin Biochem, Southampton, Hants, England.; Wainwright, P (corresponding author), Southampton Univ Hosp, Dept Lab Med, Chem Pathol & Metab Med, D Level Pathol Block, Tremona Rd, Southampton SO16 6YD, Hants, England.
EM patrick.wainwright@uhs.nhs.uk
RI Scorletti, Eleonora/GMX-0079-2022
OI Scorletti, Eleonora/0000-0002-7547-146X; Byrne, Christopher
   D/0000-0001-6322-7753
FU Southampton National Institute for Health Research Biomedical Research
   Centre
FX C. D. Byrne is supported in part by the Southampton National Institute
   for Health Research Biomedical Research Centre.
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NR 77
TC 32
Z9 35
U1 1
U2 21
PU CURRENT MEDICINE GROUP
PI PHILADELPHIA
PA 400 MARKET STREET, STE 700, PHILADELPHIA, PA 19106 USA
SN 1534-4827
EI 1539-0829
J9 CURR DIABETES REP
JI Curr. Diabetes Rep.
PD MAR
PY 2017
VL 17
IS 4
AR 20
DI 10.1007/s11892-017-0851-x
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA EQ2SX
UT WOS:000397922100001
PM 28290049
DA 2025-06-11
ER

PT J
AU Zabetian-Targhi, F
   Mahmoudi, MJ
   Rezaei, N
   Mahmoudi, M
AF Zabetian-Targhi, Fateme
   Mahmoudi, Mohammad J.
   Rezaei, Nima
   Mahmoudi, Maryam
TI Retinol Binding Protein 4 in Relation to Diet, Inflammation, Immunity,
   and Cardiovascular Diseases
SO ADVANCES IN NUTRITION
LA English
DT Review
DE retinol binding protein 4; cardiovascular diseases; inflammation;
   immunity; antioxidants; diet; adipokines
ID CORONARY-ARTERY-DISEASE; VITAMIN-A METABOLISM; TYPE-2 DIABETES-MELLITUS;
   INSULIN-RESISTANCE; SERUM RETINOL; RISK-FACTORS; ENDOTHELIAL-CELLS;
   MEMBRANE-RECEPTOR; CELLULAR UPTAKE; OBESE CHILDREN
AB Retinol binding protein 4 (RBP4), previously called retinol binding protein (RBP), is considered a specific carrier of retinol in the blood. It is also an adipokine that has been implicated in the pathophysiology of insulin resistance. RBP4 seems to be correlated with cardiometabolic markers in inflammatory chronic diseases, including obesity, type 2 diabetes, metabolic syndrome, and cardiovascular diseases (CVDs). It has recently been suggested that inflammation produced by RBP4 induces insulin resistance and CVD. The clinical relevance of this hypothesis is discussed in this review. Knowledge concerning the association of RBP4 with inflammation markers, oxidative stress, and CVDs as well as concerning the role of diet and antioxidants in decreasing RBP4 concentrations are discussed. Special attention is given to methodologies used in previously published studies and covariates that should be controlled when planning new studies on this adipokine.
C1 [Zabetian-Targhi, Fateme; Mahmoudi, Maryam] Univ Tehran Med Sci, Dept Cellular Mol Nutr, Sch Nutr Sci & Dietet, Tehran, Iran.
   [Rezaei, Nima] Univ Tehran Med Sci, Res Ctr Immunodeficiencies, Childrens Med Ctr, Tehran, Iran.
   [Mahmoudi, Mohammad J.] Univ Tehran Med Sci, Div Cardiol, Dept Internal Med, Tehran, Iran.
   [Rezaei, Nima] Univ Tehran Med Sci, Dept Immunol, Sch Med, Tehran, Iran.
   [Rezaei, Nima] USERN, Tehran, Iran.
C3 Tehran University of Medical Sciences; Tehran University of Medical
   Sciences; Tehran University of Medical Sciences; Tehran University of
   Medical Sciences
RP Mahmoudi, M (corresponding author), Univ Tehran Med Sci, Dept Cellular Mol Nutr, Sch Nutr Sci & Dietet, Tehran, Iran.
EM m-mahmoudi@sina.tums.ac.ir
RI Rezaei, Nima/B-4245-2008
OI Rezaei, Nima/0000-0002-3836-1827; Zabetiantarghi,
   Fateme/0000-0003-3429-6682
FU Tehran University of Medical Sciences and Health Services
   [92-03-161-24440]
FX Supported by Tehran University of Medical Sciences and Health Services
   (grant 92-03-161-24440).
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NR 117
TC 105
Z9 116
U1 1
U2 25
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 2161-8313
EI 2156-5376
J9 ADV NUTR
JI Adv. Nutr.
PD NOV
PY 2015
VL 6
IS 6
BP 748
EP 762
DI 10.3945/an.115.008292
PG 15
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA CV8ZQ
UT WOS:000364577400012
PM 26567199
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU de Zoete, MR
   Palm, NW
   Zhu, S
   Flavell, RA
AF de Zoete, Marcel R.
   Palm, Noah W.
   Zhu, Shu
   Flavell, Richard A.
TI Inflammasomes
SO COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY
LA English
DT Article
ID NF-KAPPA-B; NOD-LIKE RECEPTOR; THIOREDOXIN-INTERACTING PROTEIN; ANTHRAX
   LETHAL TOXIN; COLD AUTOINFLAMMATORY SYNDROME;
   SYSTEMIC-LUPUS-ERYTHEMATOSUS; AUTOIMMUNE ADDISONS-DISEASE; INNATE IMMUNE
   RECOGNITION; III SECRETION APPARATUS; APOE-DEFICIENT MICE
AB Inflammasomes are large cytosolic multiprotein complexes that assemble in response to detection of infection-or stress-associated stimuli and lead to the activation of caspase-1-mediated inflammatory responses, including cleavage and unconventional secretion of the leaderless proinflammatory cytokines IL-1 beta and IL-18, and initiation of an inflammatory form of cell death referred to as pyroptosis. Inflammasome activation can be induced by a wide variety of microbial pathogens and generally mediates host defense through activation of rapid inflammatory responses and restriction of pathogen replication. In addition to its role in defense against pathogens, recent studies have suggested that the inflammasome is also a critical regulator of the commensal microbiota in the intestine. Finally, inflammasomes have been widely implicated in the development and progression of various chronic diseases, such as gout, atherosclerosis, and metabolic syndrome. In this perspective, we discuss the role of inflammasomes in infectious and noninfectious inflammation and highlight areas of interest for future studies of inflammasomes in host defense and chronic disease.
C1 [de Zoete, Marcel R.; Palm, Noah W.; Zhu, Shu; Flavell, Richard A.] Yale Univ, Sch Med, Dept Immunobiol, New Haven, CT 06520 USA.
   [Flavell, Richard A.] Yale Univ, Howard Hughes Med Inst, New Haven, CT 06520 USA.
C3 Yale University; Howard Hughes Medical Institute; Yale University
RP Flavell, RA (corresponding author), Yale Univ, Sch Med, Dept Immunobiol, New Haven, CT 06520 USA.
EM richard.flavell@yale.edu
RI de Zoete, Marcel/ABA-7918-2021; Flavell, Richard/ACH-3245-2022; Zhu,
   Shu/P-6163-2018
OI de Zoete, Marcel/0000-0002-6561-5810; Zhu, Shu/0000-0002-8163-0869;
   Palm, Noah/0000-0001-7262-9455; Flavell, Richard/0000-0003-4461-0778
FU Rubicon Fellowship from the Netherlands Organization of Scientific
   Research (NWO); Cancer Research Institute Irvington Fellowship Program;
   Howard Hughes Medical Institute-The Helen Hay Whitney Foundation;
   Department of Defense [W81XWH-11-1-0745]; Howard Hughes Medical
   Institute
FX This work was supported by a Rubicon Fellowship from the Netherlands
   Organization of Scientific Research (NWO) (M.R.d.Z.), the Cancer
   Research Institute Irvington Fellowship Program (N.W.P.), a fellowship
   from Howard Hughes Medical Institute-The Helen Hay Whitney Foundation
   (S.Z.), Department of Defense Grant (W81XWH-11-1-0745) (R.A.F.), and the
   Howard Hughes Medical Institute (R.A.F. and M.R.d.Z.).
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NR 221
TC 298
Z9 315
U1 1
U2 29
PU COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
PI COLD SPRING HARBOR
PA 1 BUNGTOWN RD, COLD SPRING HARBOR, NY 11724 USA
SN 1943-0264
J9 CSH PERSPECT BIOL
JI Cold Spring Harbor Perspect. Biol.
PD DEC
PY 2014
VL 6
IS 12
AR a016287
DI 10.1101/cshperspect.a016287
PG 22
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA AW7MX
UT WOS:000346449100010
PM 25324215
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Wierzbicki, AS
   Oben, J
AF Wierzbicki, Anthony S.
   Oben, Jude
TI Nonalcoholic fatty liver disease and lipids
SO CURRENT OPINION IN LIPIDOLOGY
LA English
DT Review
DE cholesterol; hypoglycaemic; insulin resistance; lipid-lowering;
   nonalcoholic fatty liver; steatohepatitis; triglyceride
ID APOLIPOPROTEIN B-100 KINETICS; HEPATIC INSULIN-RESISTANCE; TYPE-2
   DIABETES-MELLITUS; ACTIVATED RECEPTOR-ALPHA; POPULATION-BASED COHORT;
   CORONARY-HEART-DISEASE; POST-HOC ANALYSIS; METABOLIC SYNDROME;
   CARDIOVASCULAR-DISEASE; OBESE SUBJECTS
AB Purpose of review
   This article reviews the mechanisms leading to the development of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) and the effects of hypoglycaemic and lipid-lowering therapies on NAFLD/NASH.
   Recent findings
   The interaction of lipogenesis, fatty acid oxidation, inflammation, endoplasmic reticulum stress and hepatic insulin resistance contribute to the pathogenesis of NAFLD/NASH. Few large scale clinical trials exist with biopsy or magnetic resonance endpoints as opposed to ultrasonographic and transaminase endpoints. Trial evidence that exists supports the utility of weight loss, metformin, thiazolidinediones, fibrates, niacin, ezetimibe and statins in improving the steatosis component of NAFLD/NASH though with less or minimal effects on the fibrotic component of NASH.
   Summary
   Hypoglycaemic and lipid-lowering therapies may have a role in the treatment of NAFLD/NASH but large scale endpoint trials remain to be performed.
C1 [Wierzbicki, Anthony S.] Guys & St Thomas Hosp, Dept Metab Med Chem Pathologyem Pathol, London, England.
   [Oben, Jude] Guys & St Thomas Hosp, Dept Gastroenterol, London, England.
C3 Guy's & St Thomas' NHS Foundation Trust; Guy's & St Thomas' NHS
   Foundation Trust
RP Wierzbicki, AS (corresponding author), St Thomas Hosp, Dept Chem Pathol, Lambeth Palace Rd, London SE1 7EH, England.
EM Anthony.wierzbicki@kcl.ac.uk
RI Wierzbicki, Anthony/AAP-1735-2020; OBEN, JUDE/K-4331-2013
OI Wierzbicki, Anthony/0000-0003-2756-372X; Oben, Jude
   Augustine/0000-0003-3350-8356
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NR 101
TC 50
Z9 51
U1 0
U2 18
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0957-9672
EI 1473-6535
J9 CURR OPIN LIPIDOL
JI Curr. Opin. Lipidology
PD AUG
PY 2012
VL 23
IS 4
BP 345
EP 352
DI 10.1097/MOL.0b013e3283541cfc
PG 8
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism; Peripheral
   Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism;
   Cardiovascular System & Cardiology
GA 975PH
UT WOS:000306522800010
PM 22617751
DA 2025-06-11
ER

PT J
AU La Merrill, M
   Birnbaum, LS
AF La Merrill, Michele
   Birnbaum, Linda S.
TI Childhood Obesity and Environmental Chemicals
SO MOUNT SINAI JOURNAL OF MEDICINE
LA English
DT Article
DE environmental exposure; growth and development; obesity
ID POLYBROMINATED DIPHENYL ETHERS; PERSISTENT ORGANIC POLLUTANTS; BODY-MASS
   INDEX; ENDOPLASMIC-RETICULUM STRESS; NUTRITION EXAMINATION SURVEY;
   FAT-CELL TURNOVER; BISPHENOL-A; METABOLIC SYNDROME; INSULIN-RESISTANCE;
   WEIGHT-GAIN
AB Childhood and adolescent rates of obesity and overweight are continuing to increase in much of the world. Risk. factors such as diet composition, excess caloric intake, decreased exercise, genetics, and the built environment are active areas of etiologic research. The obesogen hypothesis, which postulates that prenatal and perinatal chemical exposure can contribute to risk of childhood and adolescent obesity, remains relatively underexamined. This review surveys numerous classes of chemicals for which this hypothesis has been explored. We focus on human data where they exist and also discuss the findings of rodent and cell culture studies. Organochlorine chemicals as well as several classes of chemicals that are peroxisome proliferator-activated receptor agonists are identified as possible risk factors for obesity. Recommendations for future epidemiologic and experimental research on the chemical origins of obesity are also given. Mt Sinai J Med 78:22-48, 2011. (C) 2011 Mount Sinai School of Medicine
C1 [La Merrill, Michele] Mt Sinai Sch Med, New York, NY 10029 USA.
   [Birnbaum, Linda S.] NIEHS, NCI, Res Triangle Pk, NC USA.
C3 Icahn School of Medicine at Mount Sinai; National Institutes of Health
   (NIH) - USA; NIH National Institute of Environmental Health Sciences
   (NIEHS); NIH National Cancer Institute (NCI)
RP La Merrill, M (corresponding author), Mt Sinai Sch Med, New York, NY 10029 USA.
EM Michele.LaMerrill@mssm.edu
OI Birnbaum, Linda/0000-0001-5429-5658
FU National Institutes of Health [ML: T32HD049311]
FX This research was funded by the Research Training Program in
   Environmental Pediatrics of the National Institutes of Health (ML:
   T32HD049311).
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NR 189
TC 131
Z9 145
U1 0
U2 40
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0027-2507
EI 1931-7581
J9 MT SINAI J MED
JI Mt. Sinai J. Med.
PD JAN-FEB
PY 2011
VL 78
IS 1
BP 22
EP 48
DI 10.1002/msj.20229
PG 27
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 717BN
UT WOS:000287017300003
PM 21259261
OA Bronze, Green Accepted
DA 2025-06-11
ER

PT J
AU Baldelli, S
   Aiello, G
   Di Martino, EM
   Campaci, D
   Muthanna, FMS
   Lombardo, M
AF Baldelli, Sara
   Aiello, Gilda
   Di Martino, Eliana Mansilla
   Campaci, Diego
   Muthanna, Fares M. S.
   Lombardo, Mauro
TI The Role of Adipose Tissue and Nutrition in the Regulation of
   Adiponectin
SO NUTRIENTS
LA English
DT Review
DE adipose tissue; adiponectin; metabolic homeostasis; insulin sensitivity;
   dietary interventions; metabolic diseases; type 2 diabetes;
   cardiovascular disease; fatty acid metabolism; endocrine function;
   adipokines; nutritional therapy; physical activity
ID HIGH-FAT DIET; ACTIVATED PROTEIN-KINASE; STOP HYPERTENSION DASH; PLASMA
   ADIPONECTIN; INSULIN SENSITIVITY; METABOLIC SYNDROME; OXIDATIVE STRESS;
   LIVER-DISEASE; PROBIOTIC SUPPLEMENTATION; CELLULAR MECHANISMS
AB Adipose tissue (AT), composed mainly of adipocytes, plays a critical role in lipid control, metabolism, and energy storage. Once considered metabolically inert, AT is now recognized as a dynamic endocrine organ that regulates food intake, energy homeostasis, insulin sensitivity, thermoregulation, and immune responses. This review examines the multifaceted role of adiponectin, a predominant adipokine released by AT, in glucose and fatty acid metabolism. We explore the regulatory mechanisms of adiponectin, its physiological effects and its potential as a therapeutic target for metabolic diseases such as type 2 diabetes, cardiovascular disease and fatty liver disease. Furthermore, we analyze the impact of various dietary patterns, specific nutrients, and physical activities on adiponectin levels, highlighting strategies to improve metabolic health. Our comprehensive review provides insights into the critical functions of adiponectin and its importance in maintaining systemic metabolic homeostasis.
C1 [Baldelli, Sara; Aiello, Gilda; Di Martino, Eliana Mansilla; Campaci, Diego; Lombardo, Mauro] San Raffaele Open Univ, Dept Promot Human Sci & Qual Life, Via Val Cannuta, 247, I-00166 Rome, Italy.
   [Baldelli, Sara] IRCCS San Raffaele Roma, I-00166 Rome, Italy.
   [Muthanna, Fares M. S.] Univ Sci & Technol Aden, Fac Med & Hlth Sci, Pharm Dept, Alshaab St, Enmaa City 22003, Yemen.
C3 IRCCS San Raffaele Pisana
RP Lombardo, M (corresponding author), San Raffaele Open Univ, Dept Promot Human Sci & Qual Life, Via Val Cannuta, 247, I-00166 Rome, Italy.
EM elianaayelen.mans@studenti.uniroma5.it; mauro.lombardo@uniroma5.it
RI Aiello, Gilda/KQU-5207-2024; Lombardo, Mauro/F-6133-2019; BALDELLI,
   SARA/G-4318-2015
OI Alabyadh, Mokhtar/0009-0004-2378-7771; Lombardo,
   Mauro/0000-0001-7509-5487; Aiello, Gilda/0000-0003-4327-0521; Campaci,
   Diego/0009-0008-4238-2146; Mothana, Faris M/0000-0002-7722-9466;
   BALDELLI, SARA/0000-0001-7003-3172
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PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD AUG
PY 2024
VL 16
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AR 2436
DI 10.3390/nu16152436
PG 34
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA C1S5K
UT WOS:001287229000001
PM 39125318
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Limpitikul, WB
   Das, S
AF Limpitikul, Worawan B.
   Das, Saumya
TI Obesity-Related Atrial Fibrillation: Cardiac Manifestation of a Systemic
   Disease
SO JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
LA English
DT Review
DE atrial fibrillation; obesity; metabolic syndrome; adiposity; atrial
   myopathy; atrial remodeling
ID HIGH-FAT DIET; BODY-MASS INDEX; ADIPOSE-TISSUE; EXTRACELLULAR VESICLES;
   CARDIOVASCULAR-DISEASE; EPICARDIAL FAT; HEART-FAILURE; WEIGHT-LOSS;
   RISK-FACTOR; ABLATION
AB Atrial fibrillation (AF) is the most common arrhythmia worldwide and is associated with increased morbidity and mortality. The mechanisms underlying AF are complex and multifactorial. Although it is well known that obesity is a strong risk factor for AF, the mechanisms underlying obesity-related AF are not completely understood. Current evidence proposes that in addition to overall hemodynamic changes due to increased body weight, excess adiposity raises systemic inflammation and oxidative stress, which lead to adverse atrial remodeling. This remodeling includes atrial fibrosis, atrial dilation, decreased electrical conduction between atrial myocytes, and altered ionic currents, making atrial tissue more vulnerable to both the initiation and maintenance of AF. However, much remains to be learned about the mechanistic links between obesity and AF. This knowledge will power the development of novel diagnostic tools and treatment options that will help combat the rise of the global AF burden among the obesity epidemic.
C1 [Limpitikul, Worawan B.; Das, Saumya] Harvard Med Sch, Massachusetts Gen Hosp, Cardiovasc Res Ctr, Boston, MA 02114 USA.
   [Das, Saumya] Massachusetts Gen Hosp, Demoulas Family Fdn Ctr Cardiac Arrhythmias, Boston, MA 02114 USA.
C3 Harvard University; Harvard Medical School; Harvard University Medical
   Affiliates; Massachusetts General Hospital; Harvard University; Harvard
   University Medical Affiliates; Massachusetts General Hospital
RP Das, S (corresponding author), Harvard Med Sch, Massachusetts Gen Hosp, Cardiovasc Res Ctr, Boston, MA 02114 USA.; Das, S (corresponding author), Massachusetts Gen Hosp, Demoulas Family Fdn Ctr Cardiac Arrhythmias, Boston, MA 02114 USA.
EM wlimpitikul@mgh.harvard.edu; sdas@mgh.harvard.edu
RI Das, Saumya/R-7644-2019
OI Limpitikul, Worawan/0000-0001-6171-9906
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NR 130
TC 2
Z9 2
U1 2
U2 7
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2308-3425
J9 J CARDIOVASC DEV DIS
JI J. Cardiovasc. Dev. Dis.
PD AUG
PY 2023
VL 10
IS 8
AR 10323
DI 10.3390/jcdd10080323
PG 19
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA Q2GP5
UT WOS:001055755900001
PM 37623336
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Wu, ST
   Wang, XX
   Xing, WB
   Li, FY
   Liang, M
   Li, KS
   He, Y
   Wang, JM
AF Wu, ShuTing
   Wang, XinXin
   Xing, WenBo
   Li, FenYao
   Liang, Ming
   Li, KeShen
   He, Yan
   Wang, JianMing
TI An update on animal models of liver fibrosis
SO FRONTIERS IN MEDICINE
LA English
DT Review
DE liver fibrosis; liver injury; inflammation; in vivo; animal models
ID HIGH-FAT DIET; NONALCOHOLIC STEATOHEPATITIS; HEPATIC-FIBROSIS; OXIDATIVE
   STRESS; HIGH-FRUCTOSE; HEPATOCELLULAR-CARCINOMA; METABOLIC SYNDROME;
   CHOLINE-DEFICIENT; MOUSE MODELS; MURINE MODEL
AB The development of liver fibrosis primarily determines quality of life as well as prognosis. Animal models are often used to model and understand the underlying mechanisms of human disease. Although organoids can be used to simulate organ development and disease, the technology still faces significant challenges. Therefore animal models are still irreplaceable at this stage. Currently, in vivo models of liver fibrosis can be classified into five categories based on etiology: chemical, dietary, surgical, transgenic, and immune. There is a wide variety of animal models of liver fibrosis with varying efficacy, which have different implications for proper understanding of the disease and effective screening of therapeutic agents. There is no high-quality literature recommending the most appropriate animal models. In this paper, we will describe the progress of commonly used animal models of liver fibrosis in terms of their development mechanisms, applications, advantages and disadvantages, and recommend appropriate animal models for different research purposes.
C1 [Wu, ShuTing; Wang, XinXin; Xing, WenBo; Li, FenYao; Liang, Ming; Li, KeShen; He, Yan; Wang, JianMing] Wuhan Univ Sci & Technol, Tianyou Hosp, Inst Regenerat & Translat Med, Wuhan, Peoples R China.
   [Wang, JianMing] Wuhan Univ Sci & Technol, Tianyou Hosp, Dept Hepatobiliary & Pancreat Surg, Wuhan, Peoples R China.
C3 Wuhan University of Science & Technology; Wuhan University of Science &
   Technology
RP He, Y; Wang, JM (corresponding author), Wuhan Univ Sci & Technol, Tianyou Hosp, Inst Regenerat & Translat Med, Wuhan, Peoples R China.; Wang, JM (corresponding author), Wuhan Univ Sci & Technol, Tianyou Hosp, Dept Hepatobiliary & Pancreat Surg, Wuhan, Peoples R China.
EM helen-1101@hotmail.com; wjm18jgm@liyun.com
RI wu, shuting/JQV-8765-2023; xing, wenbo/JKJ-1449-2023
FU Wuhan University of Science and Technology Graduate School Scholarship
   [ZY24001]; Hubei Provincial Health and Health Commission Research
   Project [WJ2023M121]; WUST startup fund (Chu Tian Scholars Program)
FX We acknowledge financial support from the Wuhan University of Science
   and Technology Graduate School Scholarship (No. ZY24001), the Hubei
   Provincial Health and Health Commission Research Project (No.
   WJ2023M121), and the WUST startup fund (Chu Tian Scholars Program).
   Figure 1 was created with BioRender.com.
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NR 167
TC 29
Z9 29
U1 5
U2 34
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 2296-858X
J9 FRONT MED-LAUSANNE
JI Front. Med.
PD MAR 23
PY 2023
VL 10
AR 1160053
DI 10.3389/fmed.2023.1160053
PG 16
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA C6SU4
UT WOS:000963200000001
PM 37035335
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Vettori, A
   Pompucci, G
   Paolini, B
   Del Ciondolo, I
   Bressan, S
   Dundar, M
   Kenanoglu, S
   Unfer, V
   Bertelli, M
AF Vettori, A.
   Pompucci, G.
   Paolini, B.
   Del Ciondolo, I.
   Bressan, S.
   Dundar, M.
   Kenanoglu, S.
   Unfer, V.
   Bertelli, M.
CA Geneob Project
TI Genetic background, nutrition and obesity: a review
SO EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
LA English
DT Review
DE Obesity; miRNA; Genetic Markers; Metabolic disorders
ID BODY-MASS INDEX; MEDITERRANEAN DIET; POLYCYSTIC-OVARY; INFLAMMATORY
   MARKERS; METABOLIC SYNDROME; FAT PREFERENCES; ADIPOSE-TISSUE;
   HIGH-PROTEIN; CD36 LOCUS; RISK
AB OBJECTIVE: To summarize the latest information on the relationship between genes and common forms of obesity, and to review genetic markers (SNPs and miRNA) that play a role in predisposing to common forms of obesity and related disorders.
   MATERIALS AND METHODS: We searched PubMed with the following keywords: (obesity[Title/Abstract]) AND predisposition[Title/Abstract]) AND miRNA[Title/Abstract]) OR polymorphism[Title/Abstract].
   RESULTS: From the search we obtained a total of 44 gene loci and 48 miRNAs associated with common obesity.
   CONCLUSIONS: It is now widely accepted that obesity involves interactions between environmental risk factors (physical inactivity, excessive calorie intake, chronic stress, taste perception) and a genetic background of risk. Analysis of the genetic background of obese subjects is therefore an important way to determine the molecular mechanisms controlling the link between food intake and obesity, enabling a better understanding of how these interactions may differ from person to person.
C1 [Vettori, A.] Univ Verona, Dept Biotechnol, Verona, Italy.
   [Pompucci, G.] Univ Siena, Dept Biotechnol Chem & Pharm, Siena, Italy.
   [Paolini, B.; Del Ciondolo, I.] Azienda Osped Univ Senese, Dept Dietet & Clin Nutr, Policlin Santa Maria Scotte, Siena, Italy.
   [Bressan, S.] MAGIS Lab, Genet Testing Lab, Rovereto, TN, Italy.
   [Dundar, M.; Kenanoglu, S.] Erciyes Univ, Dept Med Genet, Kayseri, Turkey.
   [Unfer, V.] Univ Roma La Sapienza, Fac Med & Psychol, Dept Dev & Social Psychol, Rome, Italy.
   [Bertelli, M.] MAGI Euregio, Nonprofit Genet Testing Lab, Bolzano, Italy.
C3 University of Verona; University of Siena; University of Siena;
   University Hospital of Siena; Erciyes University; Sapienza University
   Rome
RP Vettori, A (corresponding author), Univ Verona, Dept Biotechnol, Verona, Italy.
EM andrea.vettori@univr.it
RI Kenanoglu, Sercan/AAE-6807-2022; unfer, vittorio/AFN-5588-2022; Vettori,
   Andrea/J-3951-2014; Dundar, Munis/B-3150-2011
OI unfer, vittorio/0000-0002-1805-3181; Vettori,
   Andrea/0000-0003-4958-0619; Dundar, Munis/0000-0003-0969-4611;
   Kenanoglu, Sercan/0000-0003-2239-0209
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NR 82
TC 29
Z9 29
U1 0
U2 16
PU VERDUCI PUBLISHER
PI ROME
PA VIA GREGORIO VII, ROME, 186-00165, ITALY
SN 1128-3602
J9 EUR REV MED PHARMACO
JI Eur. Rev. Med. Pharmacol. Sci.
PD FEB
PY 2019
VL 23
IS 4
BP 1751
EP 1761
PG 11
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA HO1GJ
UT WOS:000460653200046
PM 30840300
DA 2025-06-11
ER

PT J
AU Feng, SM
   Gan, L
   Yang, CS
   Liu, AB
   Lu, WY
   Shao, P
   Dai, ZQ
   Sun, PL
   Luo, ZS
AF Feng, Simin
   Gan, Ling
   Yang, Chung S.
   Liu, Anna B.
   Lu, Wenyun
   Shao, Ping
   Dai, Zhuqing
   Sun, Peilong
   Luo, Zisheng
TI Effects of Stigmasterol and β-Sitosterol on Nonalcoholic Fatty Liver
   Disease in a Mouse Model: A Lipidomic Analysis
SO JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
LA English
DT Article
DE stigmasterol; beta-sitosterol; fatty liver; mice; cholesterol;
   lipidomics
ID SACCHARUM-OFFICINARUM L.; WESTERN-STYLE DIET; OXIDATIVE STRESS; PLANT
   STEROLS; HEPATIC INFLAMMATION; LOWERING PROPERTIES; METABOLIC SYNDROME;
   CHOLESTEROL; MICE; PHYTOSTEROLS
AB To study the effects of stigmasterol and beta-sitosterol on high-fat Western diet (HFWD)-induced nonalcoholic fatty liver disease (NAFLD), lipidomic analyses were conducted in liver samples collected after 33 weeks of the treatment. Principal component analysis showed these phytosterols were effective in protecting against HFWD-induced NAFLD. Orthogonal projections to latent structures-discriminate analysis (OPLS-DA) and S-plots showed that triacylglycerols (TGs), phosphatidylcholines, cholesteryl esters, diacylglycerols, and free fatty acids (FFAs) were the major lipid species contributing to these discriminations. The alleviation of NAFLD is mainly associated with decreases in hepatic cholesterol, TGs with polyunsaturated fatty acids, and alterations of free hepatic FFA. In condusion, phytosterols, at a dose comparable to that suggested for humans by the FDA for the reduction of plasma cholesterol levels, are shown to protect against NAFLD in this long-term (33-week) study.
C1 [Feng, Simin; Gan, Ling; Shao, Ping; Sun, Peilong] Zhejiang Univ Technol, Dept Food Sci & Technol, Hangzhou 310014, Zhejiang, Peoples R China.
   [Feng, Simin; Yang, Chung S.; Liu, Anna B.] Rutgers State Univ, Ernest Mario Sch Pharm, Dept Chem Biol, Piscataway, NJ 08854 USA.
   [Feng, Simin; Luo, Zisheng] Zhejiang Univ, Coll Biosyst Engn & Food Sci, Key Lab Agroprod Postharvest Handling, Zhejiang Key Lab Agrifood Proc,Minist Agr, Hangzhou 310058, Zhejiang, Peoples R China.
   [Dai, Zhuqing] Jiangsu Acad Agr Sci, Inst Agroprod Proc, Nanjing 210014, Jiangsu, Peoples R China.
   [Lu, Wenyun] Princeton Univ, Dept Chem, Princeton, NJ 08544 USA.
   [Lu, Wenyun] Princeton Univ, Lewis Sigler Inst Integrat Genom, Princeton, NJ 08544 USA.
C3 Zhejiang University of Technology; Rutgers University System; Rutgers
   University New Brunswick; Ministry of Agriculture & Rural Affairs;
   Zhejiang University; Jiangsu Academy of Agricultural Sciences; Princeton
   University; Princeton University
RP Sun, PL (corresponding author), Zhejiang Univ Technol, Dept Food Sci & Technol, Hangzhou 310014, Zhejiang, Peoples R China.; Luo, ZS (corresponding author), Zhejiang Univ, Coll Biosyst Engn & Food Sci, Key Lab Agroprod Postharvest Handling, Zhejiang Key Lab Agrifood Proc,Minist Agr, Hangzhou 310058, Zhejiang, Peoples R China.
EM sun_pl@zjut.edu.cn; luozisheng@zju.edu.cn
RI Sun, Peilong/G-3151-2011; Dai, Zhuqing/ITT-8124-2023; Luo,
   Zisheng/JQW-5807-2023
OI luo, zisheng/0000-0001-8232-9739; Feng, Simin/0000-0001-8885-5801
FU Key Research and Development Program of Zhejiang Province [2018C02049];
   Hangzhou Science and Technology Development Program [20170432B24]; U.S.
   National Institutes of Health [CA120915, CA211437]; John L. Colaizzi
   Chair Endowment fund; General Financial Grant from China Postdoctoral
   Science Foundation [2017M621970];  [CA72720];  [ES05022]
FX The research was supported by the Key Research and Development Program
   of Zhejiang Province (2018C02049) and Hangzhou Science and Technology
   Development Program (20170432B24). The work in the United States was
   supported by grants from the U.S. National Institutes of Health CA120915
   (to C.S.Y.) and CA211437 (to W.L.) and shared facilities funded by
   CA72720 and ES05022 as well as the John L. Colaizzi Chair Endowment fund
   (to C.S.Y.). This work was also supported by General Financial Grant
   from the China Postdoctoral Science Foundation 2017M621970.
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NR 45
TC 88
Z9 96
U1 0
U2 68
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0021-8561
EI 1520-5118
J9 J AGR FOOD CHEM
JI J. Agric. Food Chem.
PD APR 4
PY 2018
VL 66
IS 13
BP 3417
EP 3425
DI 10.1021/acs.jafc.7b06146
PG 9
WC Agriculture, Multidisciplinary; Chemistry, Applied; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture; Chemistry; Food Science & Technology
GA GC1AG
UT WOS:000429508400019
PM 29583004
DA 2025-06-11
ER

PT J
AU Yang, X
   Sun, L
   Zhao, A
   Hu, X
   Qing, Y
   Jiang, J
   Yang, C
   Xu, T
   Wang, P
   Liu, J
   Zhang, J
   He, L
   Jia, W
   Wan, C
AF Yang, X.
   Sun, L.
   Zhao, A.
   Hu, X.
   Qing, Y.
   Jiang, J.
   Yang, C.
   Xu, T.
   Wang, P.
   Liu, J.
   Zhang, J.
   He, L.
   Jia, W.
   Wan, C.
TI Serum fatty acid patterns in patients with schizophrenia: a targeted
   metabonomics study
SO TRANSLATIONAL PSYCHIATRY
LA English
DT Article
ID COA DESATURASE ACTIVITY; DRUG-NAIVE PATIENTS; OXIDATIVE STRESS;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; GLUCOSE-TOLERANCE; BRAIN;
   HUMANS; TISSUE; 1ST-EPISODE
AB Previous studies have indicated that schizophrenia is linked to abnormal lipid metabolism. Free fatty acids (FFAs) in peripheral blood can reflect the status of lipid metabolism in human body. The purpose of this study was to scan the FFA pattern and elucidate the characteristics of lipid metabolic abnormality in schizophrenia patients. One hundred and ten patients with schizophrenia (SCZs) and 109 healthy controls (HCs) were included in the study and divided into a discovery set and a validation set. Forty-seven serum FFAs were detected by UPLC-QTOF-MS and 39 of them were absolutely quantified by establishing standard curves. Monounsaturated fatty acids (MUFAs) and omega-6 polyunsaturated fatty acids (omega-6 PUFAs) were significantly increased in SCZs compared with HCs. Desaturation from saturated fatty acids to MUFAs and beta-oxidation were enhanced, as estimated by the ratios of products to precursors. These results suggest that lipolysis and beta-oxidation are upregulated in SCZ, presumably resulting from insufficient brain energy supply.
C1 [Yang, X.; Sun, L.; Hu, X.; Qing, Y.; Jiang, J.; Yang, C.; Zhang, J.; He, L.; Wan, C.] Shanghai Jiao Tong Univ, Key Lab Genet Dev & Neuropsychiat Disorders, Key Lab Translat Psychiat, Bio X Inst,Minist Educ,Shanghai Mental Hlth Ctr, Shanghai, Peoples R China.
   [Zhao, A.; Liu, J.; Jia, W.] Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Ctr Translat Med, Shanghai, Peoples R China.
   [Zhao, A.; Liu, J.; Jia, W.] Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Shanghai Key Lab Diabet Mellitus, Shanghai, Peoples R China.
   [Xu, T.] Shanghai Jiao Tong Univ, Collaborat Innovat Ctr Brain Sci, Discipline Neurosci, Dept Anat Histol & Embryol,Sch Med, Shanghai, Peoples R China.
   [Wang, P.] Fourth Peoples Hosp Wuhu, Wuhu, Peoples R China.
   [Wan, C.] Collaborat Innovat Ctr Genet & Dev, Shanghai, Peoples R China.
C3 Ministry of Education - China; Shanghai Jiao Tong University; Shanghai
   Jiao Tong University; Shanghai Jiao Tong University; Shanghai Jiao Tong
   University
RP Jia, W (corresponding author), Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Shanghai 200233, Peoples R China.; Wan, C (corresponding author), Shanghai Jiao Tong Univ, Bio X Inst, 1954 Huashan Rd, Shanghai 200030, Peoples R China.
EM wjia@cc.hawaii.edu; clwan@sjtu.edu.cn
RI Jia, Wei/AAN-5102-2020; Jia, Weiping/B-7483-2012
OI Jia, Wei/0000-0002-3739-8994; Jia, Weiping/0000-0002-6244-2168
FU National Natural Science Foundation of China [81271486, 81421061];
   Ministry of Science and Technology of China [2016YFC1306802,
   2016YFC1306900]; Program for NSFC International (Regional) Cooperation
   and Exchange [81361120389]; Grants of Shanghai Brain-Intelligence
   Project from STCSM [16JC1420500]
FX This work was supported by the National Natural Science Foundation of
   China (81271486, 81421061), Ministry of Science and Technology of China
   (2016YFC1306802, 2016YFC1306900), the Program for NSFC International
   (Regional) Cooperation and Exchange (81361120389), Grants of Shanghai
   Brain-Intelligence Project from STCSM(16JC1420500).
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NR 53
TC 55
Z9 60
U1 1
U2 35
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 2158-3188
J9 TRANSL PSYCHIAT
JI Transl. Psychiatr.
PD JUL 25
PY 2017
VL 7
AR e1176
DI 10.1038/tp.2017.152
PG 9
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA FC3CF
UT WOS:000406715200002
PM 28742081
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Gay, JL
   Salinas, JJ
   Buchner, DM
   Mirza, S
   Kohl, HW
   Fisher-Hoch, SP
   McCormick, JB
AF Gay, Jennifer L.
   Salinas, Jennifer J.
   Buchner, David M.
   Mirza, Shaper
   Kohl, Harold W., III
   Fisher-Hoch, Susan P.
   McCormick, Joseph B.
TI Meeting Physical Activity Guidelines is Associated with Lower Allostatic
   Load and Inflammation in Mexican Americans
SO JOURNAL OF IMMIGRANT AND MINORITY HEALTH
LA English
DT Article
DE Hispanics; Exercise; Chronic disease; Inflammation
ID ACTIVITY QUESTIONNAIRE; LOGISTIC-REGRESSION; METABOLIC SYNDROME;
   UNITED-STATES; SAMPLE-SIZE; STRESS; RISK; DYSREGULATION; POPULATION;
   PREVALENCE
AB Examine the relationship between physical activity (PA) and allostatic load in Mexican-Americans as well as variations by gender. Self-reported PA as well as cardiovascular, metabolic and inflammatory markers were assessed in 330 Mexican-American adults in the Cameron County Hispanic Cohort (Brownsville, TX, USA). Dependent variables included total allostatic load, blood pressure, metabolic, and inflammatory scores. PA participation was categorized as sedentary, low, moderate, high, and by whether activity was sufficient to meet public health guidelines. Logistic regression analyses were conducted using cross-sectional data, and tested interaction effects of gender and PA. High active participants had lower allostatic load and inflammatory risk than sedentary participants. These relationships held for meeting versus not meeting guidelines. Males meeting guidelines were less likely to have high inflammation than other groups. The data did not suggest a dose-response association. These findings indicate that PA may reduce accumulation of allostatic load, highlighting the importance of a physically active lifestyle across the life span.
C1 [Gay, Jennifer L.] Univ Georgia, Dept Hlth Promot & Behav, Coll Publ Hlth, Ramsey Ctr 311, Athens, GA 30602 USA.
   [Salinas, Jennifer J.; Mirza, Shaper; Fisher-Hoch, Susan P.; McCormick, Joseph B.] Univ Texas Brownsville, Sch Publ Hlth, Div Epidemiol Human Genet & Environm Sci, Brownsville, TX 78520 USA.
   [Buchner, David M.] Univ Illinois, Coll Appl Hlth Sci, Dept Kinesiol & Community Hlth, Urbana, IL 61801 USA.
   [Kohl, Harold W., III] Univ Texas Austin, Sch Publ Hlth, Div Epidemiol Human Genet & Environm Sci, Austin, TX 78712 USA.
C3 University System of Georgia; University of Georgia; University of Texas
   System; University of Texas Rio Grande Valley; University of Illinois
   System; University of Illinois Urbana-Champaign; University of Texas
   System; University of Texas Austin
RP Gay, JL (corresponding author), Univ Georgia, Dept Hlth Promot & Behav, Coll Publ Hlth, Ramsey Ctr 311, 330 River Rd, Athens, GA 30602 USA.
EM jlgay@uga.edu
RI ; Stefanadis, Christodoulos/ABH-2232-2020
OI McCormick, Joseph/0000-0002-5844-8102; Stefanadis,
   Christodoulos/0000-0001-5974-6454
FU National Center on Minority Health and Health Disparities [NIH 1 P20
   MD002283-01]; Clinical Translational Science Award from the National
   Center for Research Resources, National Institutes of Health
   [5UL1RR024148]
FX This study was supported by National Center on Minority Health and
   Health Disparities (NIH 1 P20 MD002283-01) and Clinical Translational
   Science Award Grant Number 5UL1RR024148 from the National Center for
   Research Resources, National Institutes of Health.
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NR 33
TC 43
Z9 58
U1 0
U2 14
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1557-1912
EI 1557-1920
J9 J IMMIGR MINOR HEALT
JI J. Immigr. Minor. Health
PD APR
PY 2015
VL 17
IS 2
BP 574
EP 581
DI 10.1007/s10903-013-9950-1
PG 8
WC Public, Environmental & Occupational Health
WE Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA CE0UW
UT WOS:000351524000033
PM 24242155
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Miao, X
   Sun, WX
   Miao, LN
   Fu, YW
   Wang, YG
   Su, GF
   Liu, Q
AF Miao, Xiao
   Sun, Weixia
   Miao, Lining
   Fu, Yaowen
   Wang, Yonggang
   Su, Guanfang
   Liu, Quan
TI Zinc and Diabetic Retinopathy
SO JOURNAL OF DIABETES RESEARCH
LA English
DT Review
ID ENDOTHELIAL GROWTH-FACTOR; INDUCED OXIDATIVE STRESS; NF-KAPPA-B;
   LIPID-PEROXIDATION; MAMMALIAN ZINC; TRANSCRIPTION FACTORS; MACULAR
   DEGENERATION; POSSIBLE PROTECTION; RETINAL METABOLISM; PIGMENT
   EPITHELIUM
AB Zinc (Zn) is an important nutrient that is involved in various physiological metabolisms. Zn dyshomeostasis is often associated with various pathogeneses of chronic diseases, such as metabolic syndrome, diabetes, and related complications. Zn is present in ocular tissue in high concentrations, particularly in the retina and choroid. Zn deficiencies have been shown to affect ocular development, cataracts, age-related macular degeneration, and even diabetic retinopathy. However, the mechanism by which Zn deficiency increases the prevalence of diabetic retinopathy remains unclear. In addition, due to the negative effect of Zn deficiency on the eye, Zn supplementation should prevent diabetic retinopathy; however, limited available data do not always support this notion. Therefore, the goal of this paper was to summarize these pieces of available information regarding Zn prevention of diabetic retinopathy. Current theories and possible mechanisms underlying the role of Zn in the eye-related diseases are discussed. The possible factors that affect the preventive effect of Zn supplementation on diabetic retinopathy were also discussed.
C1 [Miao, Xiao; Miao, Lining; Su, Guanfang] Jilin Univ, Hosp 2, Changchun 130021, Peoples R China.
   [Miao, Xiao; Su, Guanfang] Jilin Univ, Hosp 2, Dept Ophthalmol, Changchun 130041, Peoples R China.
   [Sun, Weixia; Fu, Yaowen; Wang, Yonggang; Liu, Quan] Jilin Univ, Hosp 1, Changchun 130021, Peoples R China.
   [Liu, Quan] Jilin Univ, Hosp 1, Dept Cardiovasc Dis, Changchun 130021, Jilin, Peoples R China.
C3 Jilin University; Jilin University; Jilin University; Jilin University
RP Su, GF (corresponding author), Jilin Univ, Hosp 2, Changchun 130021, Peoples R China.
EM sugf@yahoo.com; quanliu888@163.com
RI Sun, Weixia/HPG-5105-2023
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NR 91
TC 39
Z9 46
U1 0
U2 10
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2314-6745
EI 2314-6753
J9 J DIABETES RES
JI J. Diabetes Res.
PY 2013
VL 2013
AR 425854
DI 10.1155/2013/425854
PG 8
WC Endocrinology & Metabolism; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Research & Experimental Medicine
GA 140CF
UT WOS:000318631200001
PM 23671870
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Jia, XM
   Chang, TJ
   Wilson, TW
   Wu, LY
AF Jia, Xuming
   Chang, Tuanjie
   Wilson, Thomas W.
   Wu, Lingyun
TI Methylglyoxal Mediates Adipocyte Proliferation by Increasing
   Phosphorylation of Akt1
SO PLOS ONE
LA English
DT Article
ID SMOOTH-MUSCLE-CELLS; SPONTANEOUSLY HYPERTENSIVE-RATS; OXIDATIVE STRESS;
   ADIPOSE-TISSUE; DIABETES-MELLITUS; UP-REGULATION; INSULIN; ADIPOGENESIS;
   DIFFERENTIATION; PRODUCT
AB Methylglyoxal (MG) is a highly reactive metabolite physiologically presented in all biological systems. The effects of MG on diabetes and hypertension have been long recognized. In the present study, we investigated the potential role of MG in obesity, one of the most important factors to cause metabolic syndrome. An increased MG accumulation was observed in the adipose tissue of obese Zucker rats. Cell proliferation assay showed that 5-20 mu M of MG stimulated the proliferation of 3T3-L1 cells. Further study suggested that accumulated-MG stimulated the phosphorylation of Akt1 and its targets including p21 and p27. The activated Akt1 then increased the activity of CDK2 and accelerated the cell cycle progression of 3T3-L1 cells. The effects of MG were efficiently reversed by advanced glycation end product (AGE) breaker alagebrium and Akt inhibitor SH-6. In summary, our study revealed a previously unrecognized effect of MG in stimulating adipogenesis by up-regulation of Akt signaling pathway and this mechanism might offer a new approach to explain the development of obesity.
C1 [Jia, Xuming; Chang, Tuanjie; Wu, Lingyun] Univ Saskatchewan, Dept Pharmacol, Collage Med, Saskatoon, SK S7N 0W0, Canada.
   [Wilson, Thomas W.] Univ Saskatchewan, Dept Med, Collage Med, Saskatoon, SK S7N 0W0, Canada.
   [Wu, Lingyun] Lakehead Univ, Dept Hlth Sci, Thunder Bay, ON P7B 5E1, Canada.
   [Wu, Lingyun] Thunder Bay Reg Res Inst, Thunder Bay, ON, Canada.
C3 University of Saskatchewan; University of Saskatchewan; Lakehead
   University
RP Jia, XM (corresponding author), Univ Saskatchewan, Dept Pharmacol, Collage Med, Saskatoon, SK S7N 0W0, Canada.
EM lwu@lakeheadu.ca
RI Wu, Lingyun/HRD-0014-2023
FU Canadian Institutes of Health Research [MOP-68938]; Heart Stroke
   foundation of Saskatchewan; Children's Hospital Foundation of
   Saskatchewan; Heart & Stroke Foundation of Canada
FX This work is supported by operating grants of Canadian Institutes of
   Health Research (MOP-68938) (http://www.cihr-irsc.gc.ca/); Heart Stroke
   foundation of Saskatchewan
   (http://www.heartandstroke.sk.ca/site/c.inKMILNlEmG/b.3657319/k.F889/Hea
   rt_Disease_Stroke_and_Healthy_Living.htm); and Children's Hospital
   Foundation of Saskatchewan to L. Wu
   (http://www.childrenshospitalsask.ca/); X. Jia received a doctoral award
   from Heart & Stroke Foundation of Canada
   (http://www.heartandstroke.com/site/c.ikIQLcMWJtE/b.2796497/k.BF8B/Home.
   htm). The funders had no role in study design, data collection and
   analysis, decision to publish, or preparation of the manuscript.
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NR 48
TC 44
Z9 47
U1 0
U2 10
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAY 14
PY 2012
VL 7
IS 5
AR e36610
DI 10.1371/journal.pone.0036610
PG 9
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 959UF
UT WOS:000305339400025
PM 22606274
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT B
AU Seeman, T
   Epel, E
   Gruenewald, T
   Karlamangla, A
   McEwen, BS
AF Seeman, Teresa
   Epel, Elissa
   Gruenewald, Tara
   Karlamangla, Arun
   McEwen, Bruce S.
BE Adler, NE
   Stewart, J
TI Socio-economic differentials in peripheral biology: Cumulative
   allostatic load
SO BIOLOGY OF DISADVANTAGE: SOCIOECONOMIC STATUS AND HEALTH
SE Annals of the New York Academy of Sciences-Series
LA English
DT Article; Book Chapter
DE SES; allostatic load; peripheral biology
ID C-REACTIVE PROTEIN; ARTERY RISK DEVELOPMENT; CORONARY-HEART-DISEASE;
   BONE-MINERAL DENSITY; 3RD NATIONAL-HEALTH; EARLY-LIFE STRESS;
   CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; BLOOD-PRESSURE; YOUNG-ADULTS
AB This chapter focuses on evidence linking socio-economic status (SES) to "downstream" peripheral biology. Drawing on the concept of allostatic load, we examine evidence linking lower SES with greater cumulative physiological toll on multiple major biological regulatory systems over the life course. We begin by reviewing evidence linking lower SES to poorer trajectories of aging in multiple, individual physiological systems, followed by evidence of the resulting cumulative, overall burdens of physiological dysregulation seen among those of lower SES. The role of cumulative physiological dysregulation in mediating SES gradients in morbidity and mortality is then examined. We conclude with discussion of the question of interactions between SES (and other such environmental factors) and genetic endowment, and their potential consequences for patterns of physiological activity an area of research that appears poised to contribute significantly to our understanding of how social conditions "get under the skin" to affect health and aging.
C1 [Seeman, Teresa; Gruenewald, Tara; Karlamangla, Arun] Univ Calif Los Angeles, David Geffen Sch Med, Div Geriatr, Los Angeles, CA 90095 USA.
   [Epel, Elissa] Univ Calif San Francisco, Dept Psychiat, San Francisco, CA 94143 USA.
   [McEwen, Bruce S.] Rockefeller Univ, Neuroendocrinol Lab, Harold & Margaret Milliken Hatch Lab, New York, NY 10021 USA.
C3 University of California System; University of California Los Angeles;
   University of California Los Angeles Medical Center; David Geffen School
   of Medicine at UCLA; University of California System; University of
   California San Francisco; Rockefeller University
RP Seeman, T (corresponding author), Univ Calif Los Angeles, David Geffen Sch Med, Div Geriatr, 10945 Conte Ave,Suite 2339, Los Angeles, CA 90095 USA.
EM tseeman@mednet.ucla.edu
RI Epel, Elissa/ABI-6703-2022; Gruenewald, Tara/KLE-3300-2024; McEwen,
   Bruce/Z-1630-2019
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NR 201
TC 428
Z9 516
U1 0
U2 60
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER STREET, HOBOKEN, NJ, UNITED STATES
BN 978-1-57331-770-2
J9 ANN NY ACAD SCI
JI Ann.NY Acad.Sci.
PY 2010
VL 1186
BP 223
EP 239
DI 10.1111/j.1749-6632.2009.05341.x
PG 17
WC Public, Environmental & Occupational Health; Multidisciplinary Sciences
WE Book Citation Index – Science (BKCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health; Science & Technology -
   Other Topics
GA BOX21
UT WOS:000277908000012
PM 20201875
OA Bronze
DA 2025-06-11
ER

PT J
AU van Ommen, B
   Keijer, J
   Kleemann, R
   Elliott, R
   Drevon, CA
   McArdle, H
   Gibney, M
   Müller, M
AF van Ommen, Ben
   Keijer, Jaap
   Kleemann, Robert
   Elliott, Ruan
   Drevon, Christian A.
   McArdle, Harry
   Gibney, Mike
   Muller, Michael
TI The challenges for molecular nutrition research 2:: quantification of
   the nutritional phenotype
SO GENES AND NUTRITION
LA English
DT Review
DE nutritional phenotype; homeostasis; perturbation; imaging
ID C-REACTIVE PROTEIN; GENE-EXPRESSION PROFILES; IN-VIVO; DEVELOPMENTAL
   ORIGINS; METABOLIC SYNDROME; SKELETAL-MUSCLE; TRANSGENIC MICE; KAPPA-B;
   OBESITY; ATHEROSCLEROSIS
AB In quantifying the beneficial effect of dietary interventions in healthy subjects, nutrition research meets a number of new challenges. Inter individual variation in biomarker values often is larger than the effect related to the intervention. Healthy subjects have a remarkable capacity to maintain homeostasis, both through direct metabolic regulation, metabolic compensation of altered diets, and effective defence and repair mechanisms in oxidative and inflammatory stress. Processes involved in these regulatory activities essentially different from processes involved in early onset of diet related diseases. So, new concepts and approaches are needed to better quantify the subtle effects possibly achieved by dietary interventions in healthy subjects. Apart from quantification of the genotype and food intake ( these are discussed in separate reviews in this series), four major areas of innovation are discussed: the biomarker profile concept, perturbation of homeostasis combined with omics analysis, imaging, modelling and fluxes. All of these areas contribute to a better understanding and quantification of the nutritional phenotype.
C1 [van Ommen, Ben; Kleemann, Robert] TNO Qual Life, Dept Biosci, Zeist, Netherlands.
   [Keijer, Jaap] RIKILT Inst Food Safety, Wageningen, Netherlands.
   [Keijer, Jaap] Univ Wageningen & Res Ctr, Wageningen, Netherlands.
   [Elliott, Ruan] AFRC, Inst Food Res, Norwich NR4 7UA, Norfolk, England.
   [Drevon, Christian A.] Univ Oslo, Fac Med, Inst Basic Med Sci, Dept Nutr, N-0316 Oslo, Norway.
   [McArdle, Harry] Rowett Res Inst, Aberdeen, Scotland.
   [Gibney, Mike] Univ Coll Dublin, UCD Inst Food & Hlth, Dublin 2, Ireland.
   [Muller, Michael] Univ Wageningen & Res Ctr, Nutr Metab & Genom Grp, Div Human Nutr, NL-6703 HD Wageningen, Netherlands.
C3 Netherlands Organization Applied Science Research; Wageningen University
   & Research; Wageningen University & Research; University of East Anglia;
   UK Research & Innovation (UKRI); Biotechnology and Biological Sciences
   Research Council (BBSRC); John Innes Center; Quadram Institute;
   University of Oslo; University of Aberdeen; University College Dublin;
   Wageningen University & Research
RP van Ommen, B (corresponding author), TNO Qual Life, Dept Biosci, Zeist, Netherlands.
EM ben.vanommen@tno.nl; jaap.keijer@wur.nl; robert.kleemann@tno.nl;
   c.a.drevon@medisin.uio.no; h.mcardle@rowett.ac.uk; mike.gibney@ucd.ie;
   michael.muller@wur.nl
RI Drevon, Christian/F-6012-2010; Muller, Michael/M-5724-2019; Keijer,
   Jaap/J-8089-2013; Muller, Michael/B-5795-2008
OI Elliott, Ruan/0000-0001-5365-4508; Keijer, Jaap/0000-0002-9720-7491;
   Muller, Michael/0000-0002-5930-9905
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NR 71
TC 50
Z9 51
U1 0
U2 14
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1555-8932
EI 1865-3499
J9 GENES NUTR
JI Genes Nutr.
PD JUL
PY 2008
VL 3
IS 2
BP 51
EP 59
DI 10.1007/s12263-008-0084-3
PG 9
WC Genetics & Heredity; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Genetics & Heredity; Nutrition & Dietetics
GA 353YF
UT WOS:000259604600002
PM 18850187
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Chaikin, CA
   Thakkar, A
   Steffeck, AWT
   Pfrender, EM
   Hung, K
   Zhu, P
   Waldeck, NJ
   Nozawa, R
   Song, WM
   Futtner, CR
   Quattrocelli, M
   Bass, J
   Ben-Sahra, I
   Peek, CB
AF Chaikin, Claire A.
   Thakkar, Abhishek, V
   Steffeck, Adam W. T.
   Pfrender, Eric M.
   Hung, Kaitlyn
   Zhu, Pei
   Waldeck, Nathan J.
   Nozawa, Rino
   Song, Weimin
   Futtner, Christopher R.
   Quattrocelli, Mattia
   Bass, Joseph
   Ben-Sahra, Issam
   Peek, Clara B.
TI Control of circadian muscle glucose metabolism through the BMAL1-HIF
   axis in obesity
SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF
   AMERICA
LA English
DT Article
DE circadian rhythm; diet-induced obesity; skeletal muscle; hypoxia
ID SKELETAL-MUSCLE; HYPOXIC RESPONSE; FOOD-INTAKE; SHIFT WORK; CLOCK;
   PFKFB3; GENE; TIME; EXPRESSION; PROTEIN
AB Disruptions of circadian rhythms are widespread in modern society and lead to accelerated and worsened symptoms of metabolic syndrome. In healthy mice, the circadian clock factor BMAL1 is required for skeletal muscle function and metabolism. However, the importance of muscle BMAL1 in the development of metabolic diseases, such as diet- induced obesity (DIO), remains unclear. Here, we demonstrate that skeletal muscle-specific BMAL1- deficient mice exhibit worsened glucose tolerance upon high- fat diet feeding, despite no evidence of increased weight gain. Metabolite profiling from Bmal1- deficient muscles revealed impaired glucose utilization specifically at early steps in glycolysis that dictate the switch between anabolic and catabolic glucose fate. We provide evidence that this is due to abnormal control of the nutrient stress-responsive hypoxia- inducible factor glucose tolerance and expression of 217/736 dysregulated genes during DIO, including glycolytic enzymes. Together, these data indicate that during DIO, skeletal muscle BMAL1 ences the development of high- fat- diet- induced glucose intolerance.
C1 [Chaikin, Claire A.; Thakkar, Abhishek, V; Steffeck, Adam W. T.; Pfrender, Eric M.; Hung, Kaitlyn; Zhu, Pei; Ben-Sahra, Issam; Peek, Clara B.] Northwestern Univ, Feinberg Sch Med, Dept Biochem & Mol Genet, Chicago, IL 60611 USA.
   [Chaikin, Claire A.; Thakkar, Abhishek, V; Steffeck, Adam W. T.; Pfrender, Eric M.; Hung, Kaitlyn; Zhu, Pei; Waldeck, Nathan J.; Nozawa, Rino; Futtner, Christopher R.; Bass, Joseph; Peek, Clara B.] Northwestern Univ, Feinberg Sch Med, Dept Med, Div Endocrinol Metab & Mol Med, Chicago, IL 60611 USA.
   [Song, Weimin; Quattrocelli, Mattia] Cincinnati Childrens Hosp, Heart Inst, Div Mol Cardiovasc Biol, Med Ctr, Cincinnati, OH 45229 USA.
   [Song, Weimin; Quattrocelli, Mattia] Univ Cincinnati, Coll Med, Dept Pediat, Cincinnati, OH 45229 USA.
C3 Northwestern University; Feinberg School of Medicine; Northwestern
   University; Feinberg School of Medicine; Cincinnati Children's Hospital
   Medical Center; University System of Ohio; University of Cincinnati
RP Peek, CB (corresponding author), Northwestern Univ, Feinberg Sch Med, Dept Biochem & Mol Genet, Chicago, IL 60611 USA.; Peek, CB (corresponding author), Northwestern Univ, Feinberg Sch Med, Dept Med, Div Endocrinol Metab & Mol Med, Chicago, IL 60611 USA.
EM c-peek@northwestern.edu
RI Quattrocelli, Mattia/AGK-7124-2022
FU NIH Institute of Diabetes and Digestive and Kidney Diseases
   [R01DK123358]; NIH [R01HL166356, R03DK130908-01A1, R01AG078174];
   Cincinnati Children's Hospital Medical Center Research Innovation/Pilot
   Funding Program, Gap Funding Program, Children's Cancer Research Fund
   Endowed Scholarship; Heart Institute Translational Funds
   [5T32GM00806140, F31DK139621]
FX We thank all members of the Peek, Bass, Barish, Beutler, and Ben-Sahra
   labs for helpful discussion. We thank Dr. Elizabeth Bartom for
   develop-ment of the Ceto pipeline (https://github.com
   /ebartom/NGSbartom) and adaptation along with Dr. Milad Alasady. Several
   figure panels were generated with BioRender. Metabolomics services were
   provided by the Metabolomics Core Facility at Robert H. Lurie
   Comprehensive Cancer Center of Northwestern University. Metabolic
   phenotyp-ing services were provided by the Comprehensive Metabolic Core
   at Northwestern University. This research was supported by the NIH
   Institute of Diabetes and Digestive and Kidney Diseases Grant
   R01DK123358 (C.B.P.) ; NIH Grants R01HL166356, R03DK130908-01A1, and
   R01AG078174, and grants from Cincinnati Children's Hospital Medical
   Center Research Innovation/Pilot Funding Program, Gap Funding Program,
   Children's Cancer Research Fund Endowed Scholarship, and Heart Institute
   Translational Funds (M.Q.) ; 5T32GM00806140 and F31DK139621 (C.C.) .
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NR 82
TC 0
Z9 0
U1 5
U2 5
PU NATL ACAD SCIENCES
PI WASHINGTON
PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA
SN 0027-8424
EI 1091-6490
J9 P NATL ACAD SCI USA
JI Proc. Natl. Acad. Sci. U. S. A.
PD APR 1
PY 2025
VL 122
IS 13
AR e2424046122
DI 10.1073/pnas.2424046122
PG 12
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 1JZ8D
UT WOS:001466846100001
PM 40127275
OA hybrid
DA 2025-06-11
ER

PT J
AU Malloy, CR
   Sherry, AD
   Alger, JR
   Jin, ES
AF Malloy, Craig R.
   Sherry, A. Dean
   Alger, Jeffry R.
   Jin, Eunsook S.
TI Recent progress in analysis of intermediary metabolism by ex vivo
   <SUP>13</SUP>C NMR
SO NMR IN BIOMEDICINE
LA English
DT Review
DE C-13; cancer; glucose; glycerol; metabolic syndrome; NMR; stable isotope
ID TRICARBOXYLIC-ACID-CYCLE; PENTOSE-PHOSPHATE PATHWAY; REAL-TIME
   DETECTION; GLUCOSE-METABOLISM; HEPATIC GLUCONEOGENESIS; HUMAN
   GLIOBLASTOMA; TCA CYCLE; GLYCEROL; SUBSTRATE; LACTATE
AB Advanced imaging technologies, large-scale metabolomics, and the measurement of gene transcripts or enzyme expression all enable investigations of intermediary metabolism in human patients. Complementary information about fluxes in individual metabolic pathways may be obtained by ex vivo C-13 NMR of blood or tissue biopsies. Simple molecules such as C-13-labeled glucose are readily administered to patients prior to surgical biopsies, and C-13-labeled glycerol is easily administered orally to outpatients. Here, we review recent progress in practical applications of C-13 NMR to study cancer biology, the response to oxidative stress, gluconeogenesis, triglyceride synthesis in patients, as well as new insights into compartmentation of metabolism in the cytosol. The technical aspects of obtaining the sample, preparing material for analysis, and acquiring the spectra are relatively simple. This approach enables convenient, valuable, and quantitative insights into intermediary metabolism in patients.
C1 [Malloy, Craig R.; Sherry, A. Dean; Alger, Jeffry R.; Jin, Eunsook S.] Univ Texas Southwestern Med Ctr Dallas, Adv Imaging Res Ctr, 5323 Harry Hines Blvd, Dallas, TX 75390 USA.
   [Malloy, Craig R.; Sherry, A. Dean] Univ Texas Southwestern Med Ctr Dallas, Dept Radiol, Dallas, TX 75390 USA.
   [Malloy, Craig R.; Jin, Eunsook S.] Univ Texas Southwestern Med Ctr Dallas, Dept Internal Med, Dallas, TX 75390 USA.
   [Malloy, Craig R.] Vet Affairs North Texas Healthcare Syst, Dallas, TX USA.
   [Sherry, A. Dean] Univ Texas Dallas, Dept Chem, Richardson, TX 75083 USA.
   [Alger, Jeffry R.] Univ Calif Los Angeles, Dept Neurol, Geffen Sch Med, Los Angeles, CA 90024 USA.
C3 University of Texas System; University of Texas Southwestern Medical
   Center Dallas; University of Texas System; University of Texas
   Southwestern Medical Center Dallas; University of Texas System;
   University of Texas Southwestern Medical Center Dallas; University of
   Texas System; University of Texas Dallas; University of California
   System; University of California Los Angeles; University of California
   Los Angeles Medical Center; David Geffen School of Medicine at UCLA
RP Malloy, CR (corresponding author), Univ Texas Southwestern Med Ctr Dallas, Adv Imaging Res Ctr, 5323 Harry Hines Blvd, Dallas, TX 75390 USA.
EM craig.malloy@utsouthwestern.edu
RI ; Sherry, Dean/P-2348-2018
OI Malloy, Craig/0000-0001-5077-0642; Jin, Eunsook/0000-0003-3892-1000;
   Sherry, Dean/0000-0001-7150-8301
FU National Institutes of Health; NIH [EB015908, DK058398, NIH
   R37-HL034557]
FX National Institutes of Health; NIH, Grant/Award Numbers: EB015908,
   DK058398 and NIH R37-HL034557.
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NR 90
TC 2
Z9 2
U1 2
U2 17
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0952-3480
EI 1099-1492
J9 NMR BIOMED
JI NMR Biomed.
PD APR
PY 2023
VL 36
IS 4
SI SI
AR e4817
DI 10.1002/nbm.4817
EA SEP 2022
PG 14
WC Biophysics; Radiology, Nuclear Medicine & Medical Imaging; Spectroscopy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biophysics; Radiology, Nuclear Medicine & Medical Imaging; Spectroscopy
GA 9O5PT
UT WOS:000859079100001
PM 35997012
DA 2025-06-11
ER

PT J
AU Friedenreich, CM
   Morielli, AR
   Lategan, I
   Ryder-Burbidge, C
   Yang, L
AF Friedenreich, Christine M.
   Morielli, Andria R.
   Lategan, Irizelle
   Ryder-Burbidge, Charlotte
   Yang, Lin
TI Physical Activity and Breast Cancer Survival-Epidemiologic Evidence and
   Potential Biologic Mechanisms
SO CURRENT NUTRITION REPORTS
LA English
DT Article
DE Breast cancer; Physical activity; Biomarkers; Sex hormones; Insulin
   resistance; Inflammation
ID C-REACTIVE PROTEIN; SYSTEMIC INFLAMMATORY RESPONSE; QUALITY-OF-LIFE;
   GROWTH-FACTOR; POSTMENOPAUSAL WOMEN; RESISTANCE EXERCISE;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; OXIDATIVE STRESS;
   BODY-COMPOSITION
AB Purpose of Review To review the biologic mechanisms that may be operative between physical activity and survival after breast cancer. Recent Findings Physical activity decreases risk of mortality from breast cancer by up to 40%. Several biologic mechanisms have been hypothesized to explain this association. Previous cohort studies and randomized trials have examined the primary mechanisms that appear to be operative, which involve a decrease in sex hormone levels, insulin resistance, and inflammation. The evidence is still inconsistent and several limitations in the existing literature exist. Summary Understanding the biologic mechanisms involved in the association of physical activity and breast cancer survival will provide more precision to physical activity guidelines for cancer survival. To achieve this objective, future research should include direct measurements of physical activity, sedentary behaviour, and health-related fitness to provide a more comprehensive assessment of these factors and their association with biomarkers and survival after breast cancer.
C1 [Friedenreich, Christine M.; Morielli, Andria R.; Lategan, Irizelle; Ryder-Burbidge, Charlotte; Yang, Lin] Holy Cross Ctr, Dept Canc Epidemiol & Prevent Res, Alberta Hlth Serv, Canc Care Alberta, 2210-2nd St SW, Calgary, AB T2S 3C3, Canada.
   [Friedenreich, Christine M.; Yang, Lin] Univ Calgary, Cumming Sch Med, Dept Oncol, Calgary, AB, Canada.
   [Friedenreich, Christine M.; Yang, Lin] Univ Calgary, Cumming Sch Med, Dept Community Hlth Sci, Calgary, AB, Canada.
C3 Alberta Health Services (AHS); University of Calgary; University of
   Calgary; University of Calgary
RP Friedenreich, CM (corresponding author), Holy Cross Ctr, Dept Canc Epidemiol & Prevent Res, Alberta Hlth Serv, Canc Care Alberta, 2210-2nd St SW, Calgary, AB T2S 3C3, Canada.; Friedenreich, CM (corresponding author), Univ Calgary, Cumming Sch Med, Dept Oncol, Calgary, AB, Canada.; Friedenreich, CM (corresponding author), Univ Calgary, Cumming Sch Med, Dept Community Hlth Sci, Calgary, AB, Canada.
EM Christine.friedenreich@ahs.ca
RI Yang, Lin/AAE-4979-2020; Friedenreich, Christine/LKJ-4397-2024; Yang,
   Lin/H-2156-2016
OI Yang, Lin/0000-0002-1698-6666; Friedenreich,
   Christine/0000-0002-4783-1966
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NR 106
TC 7
Z9 8
U1 3
U2 13
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
EI 2161-3311
J9 CURR NUTR REP
JI Curr. Nutr. Rep.
PD DEC
PY 2022
VL 11
IS 4
BP 717
EP 741
DI 10.1007/s13668-022-00431-2
EA AUG 2022
PG 25
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 7B5XQ
UT WOS:000839579200001
PM 35953663
DA 2025-06-11
ER

PT J
AU Abenavoli, L
   Milanovic, M
   Procopio, AC
   Spampinato, G
   Maruca, G
   Perrino, EV
   Mannino, GC
   Fagoonee, S
   Luzza, F
   Musarella, CM
AF Abenavoli, Ludovico
   Milanovic, Maja
   Procopio, Anna C.
   Spampinato, Giovanni
   Maruca, Gina
   Perrino, Enrico, V
   Mannino, Gaia C.
   Fagoonee, Sharmila
   Luzza, Francesco
   Musarella, Carmelo M.
TI Ancient wheats: beneficial effects on insulin resistance
SO MINERVA MEDICA
LA English
DT Review
DE Food; Diet; Edible grain; Antioxidants; Non-alcoholic fatty liver
   disease
ID IMPROVES RISK PROFILE; TRITICUM-AESTIVUM; KHORASAN WHEAT; OXIDATIVE
   STRESS; IN-VITRO; OLD; HEALTH; DIET; TAXONOMY; BREAD
AB Non-alcoholic fatty liver disease and type 2 diabetes mellitus are two conditions that commonly co-exist in the context of metabolic syndrome. Several scientific advances in understanding this association have identified insulin resistance as the key point in the pathogenesis of both diseases. The first line treatment suggested in the management of these diseases is represented by lifestyle changes, and in particular, the modification of alimentary regimen, with the transition to a healthy diet. In this context, several studies have focused their attention on the identification of food products with beneficial actions, like ancient wheat (AW). AW is defined as the early cereals that were domesticated in their places of origin in the "Fertile Crescent" of the Middle East, and played a central role as a main source of food for the early civilizations in that region. The present narrative review aims at providing a systematic overview of the state of the art on the effects of AW on insulin resistance.
C1 [Abenavoli, Ludovico; Procopio, Anna C.; Luzza, Francesco] Magna Graecia Univ Catanzaro, Dept Hlth Sci, Viale Europa, I-88100 Catanzaro, Italy.
   [Milanovic, Maja] Univ Novi Sad, Fac Med, Dept Pharm, Novi Sad, Serbia.
   [Spampinato, Giovanni; Musarella, Carmelo M.] Univ Mediterranea, Dept Agr, Reggio Di Calabria, Italy.
   [Maruca, Gina] CNR, Inst Biosci & Bioresources, Bari, Italy.
   [Perrino, Enrico, V] Mediterranean Agron Inst, CIHEAM, Bari, Italy.
   [Mannino, Gaia C.] Magna Graecia Univ Catanzaro, Dept Med & Surg Sci, Catanzaro, Italy.
   [Fagoonee, Sharmila] CNR, Inst Biostruct & Bioimaging, Mol Biotechnol Ctr, Turin, Italy.
C3 Magna Graecia University of Catanzaro; University of Novi Sad;
   Universita Mediterranea di Reggio Calabria; Consiglio Nazionale delle
   Ricerche (CNR); Istituto di Bioscienze e Biorisorse (IBBR-CNR); CIHEAM;
   CIHEAM BARI; Magna Graecia University of Catanzaro; Consiglio Nazionale
   delle Ricerche (CNR); Istituto di Biostrutture e Bioimmagini (IBB-CNR)
RP Abenavoli, L (corresponding author), Magna Graecia Univ Catanzaro, Dept Hlth Sci, Viale Europa, I-88100 Catanzaro, Italy.
EM l.abenavoli@unicz.it
RI Perrino, Enrico/AAI-9096-2020; Milanović, Maja/JXN-5115-2024; Fagoonee,
   Sharmila/L-1940-2019; Procopio, Anna Caterina/IAP-0368-2023; Abenavoli,
   Ludovico/J-4394-2019; Spampinato, Giovanni/L-4660-2017; Musarella,
   Carmelo Maria/G-5728-2018; Mannino, Gaia Chiara/K-1580-2016
OI Spampinato, Giovanni/0000-0002-7700-841X; Musarella, Carmelo
   Maria/0000-0002-0120-190X; Perrino, Enrico Vito/0000-0002-0555-4139;
   Luzza, Francesco/0000-0001-5120-1046; Procopio, Anna
   Caterina/0000-0002-1614-4813; Mannino, Gaia Chiara/0000-0002-6341-4572;
   Milanovic, Maja/0000-0003-4082-5480; FAGOONEE,
   SHARMILA/0000-0001-6070-6716
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NR 81
TC 29
Z9 29
U1 0
U2 12
PU EDIZIONI MINERVA MEDICA
PI TURIN
PA CORSO BRAMANTE 83-85 INT JOURNALS DEPT., 10126 TURIN, ITALY
SN 0026-4806
EI 1827-1669
J9 MINERVA MED
JI Minerva Med.
PD OCT
PY 2021
VL 112
IS 5
BP 641
EP 650
DI 10.23736/S0026-4806.20.06873-1
PG 10
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA XC6YQ
UT WOS:000722156900011
PM 32729704
DA 2025-06-11
ER

PT J
AU Hayakawa, T
   Minemura, T
   Onodera, T
   Shin, J
   Okuno, Y
   Fukuhara, A
   Otsuki, M
   Shimomura, I
AF Hayakawa, Tomoaki
   Minemura, Tomomi
   Onodera, Toshiharu
   Shin, Jihoon
   Okuno, Yosuke
   Fukuhara, Atsunori
   Otsuki, Michio
   Shimomura, Iichiro
TI Impact of MR on mature adipocytes in high-fat/high-sucrose diet-induced
   obesity
SO JOURNAL OF ENDOCRINOLOGY
LA English
DT Article
DE mineralocorticoid receptor; adipocyte; obesity; insulin resistance
ID MINERALOCORTICOID RECEPTOR; ADIPOSE-TISSUE; GLUCOCORTICOID-RECEPTOR;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; DYSFUNCTION; DEFICIENCY;
   ACTIVATION; EXPRESSION; BLOCKADE
AB Active glucocorticoid levels are elevated in the adipose tissue of obesity due to the enzyme 11 beta-hydroxysteroid dehydrogenase type 1. Glucocorticoids can bind and activate both glucocorticoid receptor (GR) and mineralocorticoid receptor (MR), and pharmacological blockades of MR prevent high-fat diet-induced obesity and glucose intolerance. To determine the significance of MR in adipocytes, we generated adipocyte-specific MR-knockout mice (AdipoMR-KO) and fed them high-fat/high-sucrose diet. We found that adipocyte-specific deletion of MR did not affect the body weight, fat weight, glucose tolerance or insulin sensitivity. While liver weight was slightly reduced in AdipoMR-KO, there were no significant differences in the mRNA expression levels of genes associated with lipogenesis, lipolysis, adipocytokines and oxidative stress in adipose tissues between the control and AdipoMR-KO mice. The results indicated that MR in mature adipocytes plays a minor role in the regulation of insulin resistance and inflammation in high-fat/high-sucrose diet-induced obese mice.
C1 [Hayakawa, Tomoaki; Minemura, Tomomi; Onodera, Toshiharu; Shin, Jihoon; Okuno, Yosuke; Fukuhara, Atsunori; Otsuki, Michio; Shimomura, Iichiro] Osaka Univ, Grad Sch Med, Dept Metab Med, Osaka, Japan.
   [Shin, Jihoon] Osaka Univ, Grad Sch Med, Dept Diabet Care Med, Osaka, Japan.
   [Fukuhara, Atsunori] Osaka Univ, Grad Sch Med, Dept Adipose Management, Osaka, Japan.
C3 The University of Osaka; The University of Osaka; The University of
   Osaka
RP Fukuhara, A (corresponding author), Osaka Univ, Grad Sch Med, Dept Metab Med, Osaka, Japan.; Fukuhara, A (corresponding author), Osaka Univ, Grad Sch Med, Dept Adipose Management, Osaka, Japan.
EM fukuhara@endmet.med.osaka-u.ac.jp
RI Onodera, Toshiharu/ABA-1806-2021; Shin, Jihoon/LDF-0118-2024; Fukuhara,
   Atsunori/A-9601-2018
OI Fukuhara, Atsunori/0000-0002-6289-3778; Onodera,
   Toshiharu/0000-0002-4439-0077; Hayakawa, Tomoaki/0000-0002-4429-6558
FU Sanofi-Aventis, Inc.; Astellas Pharma Inc.; Pfizer, Inc.; Tanabe
   Mitsubishi Pharma Ltd.; Teijin Pharma Ltd.
FX This work was supported in part by grants from Sanofi-Aventis, Inc.,
   Tanabe Mitsubishi Pharma Ltd., Astellas Pharma Inc., Teijin Pharma Ltd.
   and Pfizer, Inc.
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NR 29
TC 14
Z9 15
U1 0
U2 3
PU BIOSCIENTIFICA LTD
PI BRISTOL
PA EURO HOUSE, 22 APEX COURT WOODLANDS, BRADLEY STOKE, BRISTOL BS32 4JT,
   ENGLAND
SN 0022-0795
EI 1479-6805
J9 J ENDOCRINOL
JI J. Endocrinol.
PD OCT
PY 2018
VL 239
IS 1
BP 63
EP 71
DI 10.1530/JOE-18-0026
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA HB4RW
UT WOS:000451044200007
PM 30307154
OA Bronze
DA 2025-06-11
ER

PT J
AU Yim, KM
   Armstrong, AW
AF Yim, Kaitlyn M.
   Armstrong, April W.
TI Updates on cardiovascular comorbidities associated with psoriatic
   diseases: epidemiology and mechanisms
SO RHEUMATOLOGY INTERNATIONAL
LA English
DT Review
DE Psoriasis; Comorbidities; Cardiovascular comorbidities; Mechanisms;
   Inflammation
ID MONOCYTE CHEMOATTRACTANT PROTEIN-1; NUTRITION-EXAMINATION-SURVEY;
   CHOLESTEROL EFFLUX CAPACITY; VASCULAR INFLAMMATION; METABOLIC SYNDROME;
   RHEUMATOID-ARTHRITIS; NATIONAL-HEALTH; RISK; PREVALENCE; HYPERTENSION
AB Psoriasis and psoriatic arthritis are associated with a significantly increased risk of cardiovascular risk factors and major adverse cardiovascular events (MACE). Active research is ongoing to elucidate this relationship between psoriatic diseases and cardiovascular comorbidities, as well as their shared pathogenic mechanisms. This review focuses on (1) the epidemiologic association between psoriasis and cardiovascular risk factors, (2) the epidemiologic association between psoriasis and MACE, (3) the epidemiologic association between psoriatic arthritis, cardiovascular risk factors, and MACE, and (4) proposed mechanisms for the contribution of psoriatic diseases to cardiovascular diseases. The proposed mechanisms for shared pathogenesis between psoriatic diseases and cardiovascular diseases are inflammation, insulin resistance, dyslipidemia, angiogenesis, oxidative stress, and endothelial dysfunction. There is complex interplay and overlap among these mechanisms and their contributions to shared pathogenesis. Future translational research is necessary to elucidate the link between psoriatic diseases and cardiovascular diseases. Such findings may be applied clinically to improve the lives of psoriasis patients.
C1 [Yim, Kaitlyn M.; Armstrong, April W.] Univ Southern Calif, Dept Dermatol, 1975 Zonal Ave,KAM 510,MC 9034, Los Angeles, CA 90089 USA.
C3 University of Southern California
RP Armstrong, AW (corresponding author), Univ Southern Calif, Dept Dermatol, 1975 Zonal Ave,KAM 510,MC 9034, Los Angeles, CA 90089 USA.
EM april.armstrong@med.usc.edu
FU Abbvie; Janssen; Lilly
FX Ms. Kaitlyn M. Yim declares that she has no conflict of interest. Dr.
   April W. Armstrong is a consultant for and has received honorariums from
   Abbvie, Amgen, Celgene, Janssen, Merck, Lilly, Novartis, and Pfizer. Dr.
   Armstrong has also received grants from Abbvie, Janssen, and Lilly.
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NR 66
TC 42
Z9 45
U1 0
U2 7
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0172-8172
EI 1437-160X
J9 RHEUMATOL INT
JI Rheumatol. Int.
PD JAN
PY 2017
VL 37
IS 1
BP 97
EP 105
DI 10.1007/s00296-016-3487-2
PG 9
WC Rheumatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Rheumatology
GA EI2PE
UT WOS:000392329100012
PM 27221457
DA 2025-06-11
ER

PT J
AU Li, J
   Tsuprykov, O
   Yang, XP
   Hocher, B
AF Li, Jian
   Tsuprykov, Oleg
   Yang, Xiaoping
   Hocher, Berthold
TI Paternal programming of offspring cardiometabolic diseases in later life
SO JOURNAL OF HYPERTENSION
LA English
DT Review
DE cardiometabolic diseases; epigenetics; offspring; paternal programming;
   spermatogenesis; transgenerational effects
ID HIGH-FAT DIET; EPIGENETIC TRANSGENERATIONAL INHERITANCE; SUBUNIT 825T
   ALLELE; BODY-MASS INDEX; METABOLIC-SYNDROME; GLUCOSE-INTOLERANCE; DNA
   METHYLATION; DEVELOPMENTAL ORIGINS; RADIATION-EXPOSURE; TOBACCO-SMOKE
AB Early - intrauterine - environmental factors are linked to the development of cardiovascular disease in later life. Traditionally, these factors are considered to be maternal factors such as maternal under and overnutrition, exposure to toxins, lack of micronutrients, and stress during pregnancy. However, in the recent years, it became obvious that also paternal environmental factors before conception and during sperm development determine the health of the offspring in later life. We will first describe clinical observational studies providing evidence for paternal programming of adulthood diseases in progeny. Next, we describe key animal studies proving this relationship, followed by a detailed analysis of our current understanding of the underlying molecular mechanisms of paternal programming. Alterations of noncoding sperm micro-RNAs, histone acetylation, and targeted as well as global DNA methylation seem to be in particular involved in paternal programming of offspring's diseases in later life.
C1 [Li, Jian; Hocher, Berthold] Hunan Normal Univ, Coll Med, Dept Basic Med, Changsha, Hunan, Peoples R China.
   [Tsuprykov, Oleg; Hocher, Berthold] Univ Potsdam, Inst Nutr Sci, Potsdam, Germany.
   [Tsuprykov, Oleg; Hocher, Berthold] IFLb GmbH, Inst Lab Med, Berlin, Germany.
   [Yang, Xiaoping] Hunan Normal Univ, Coll Med, Dept Pharm, Changsha, Hunan, Peoples R China.
C3 Hunan Normal University; University of Potsdam; Hunan Normal University
RP Hocher, B (corresponding author), Hunan Normal Univ, Coll Med, Dept Basic Med, Changsha, Hunan, Peoples R China.
EM hocher@uni-potsdam.de
RI Hocher, Berthold/AAC-3510-2020
OI Hocher, Berthold/0000-0001-8143-0579
FU Deutsche Forschungsgemeinschaft; National Natural Science Foundation of
   China [81300557]; Hunan Province Science and Technology Plan
   [2014SK3003]; Program for Excellent Talents of Hunan Normal University
   [ET14106]
FX Cited papers from the authors were partially supported by the Deutsche
   Forschungsgemeinschaft to B.H. and by the National Natural Science
   Foundation of China (Grant No. 81300557), by Hunan Province Science and
   Technology Plan (Grant No. 2014SK3003), and the Program for Excellent
   Talents of Hunan Normal University (Grant No. ET14106)" to J.L.
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NR 129
TC 53
Z9 56
U1 0
U2 20
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0263-6352
EI 1473-5598
J9 J HYPERTENS
JI J. Hypertens.
PD NOV
PY 2016
VL 34
IS 11
BP 2111
EP 2126
DI 10.1097/HJH.0000000000001051
PG 16
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA DZ0NI
UT WOS:000385536600002
PM 27457668
OA Green Published
DA 2025-06-11
ER

PT J
AU Nolan, CJ
   Damm, P
   Prentki, M
AF Nolan, Christopher J.
   Damm, Peter
   Prentki, Marc
TI Type 2 diabetes across generations: from pathophysiology to prevention
   and management
SO LANCET
LA English
DT Article
ID IMPAIRED GLUCOSE-TOLERANCE; GENOME-WIDE ASSOCIATION; PANCREATIC
   BETA-CELL; VISCERAL ADIPOSE-TISSUE; INSULIN-RESISTANCE; METABOLIC
   SYNDROME; LIFE-STYLE; SUSCEPTIBILITY LOCI; MELLITUS; OBESITY
AB Type 2 diabetes is now a pandemic and shows no signs of abatement. In this Seminar we review the pathophysiology of this disorder, with particular attention to epidemiology, genetics, epigenetics, and molecular cell biology. Evidence is emerging that a substantial part of diabetes susceptibility is acquired early in life, probably owing to fetal or neonatal programming via epigenetic phenomena. Maternal and early childhood health might, therefore, be crucial to the development of effective prevention strategies. Diabetes develops because of inadequate islet beta-cell and adipose-tissue responses to chronic fuel excess, which results in so-called nutrient spillover, insulin resistance, and metabolic stress. The latter damages multiple organs. Insulin resistance, while forcing beta cells to work harder, might also have an important defensive role against nutrient-related toxic effects in tissues such as the heart. Reversal of ovemutrition, healing of the beta cells, and lessening of adipose tissue defects should be treatment priorities.
C1 [Nolan, Christopher J.] Canberra Hosp, Dept Endocrinol, Canberra, ACT, Australia.
   [Nolan, Christopher J.] Australian Natl Univ, Sch Med, Canberra, ACT, Australia.
   [Damm, Peter] Univ Copenhagen, Rigshosp, Fac Hlth Sci, Dept Obstet,Ctr Pregnant Women Diabet, DK-2100 Copenhagen, Denmark.
   [Prentki, Marc] Univ Montreal, CRCHUM, Montreal, PQ H3C 3J7, Canada.
   [Prentki, Marc] Univ Montreal, Montreal Diabet Res Ctr, Montreal, PQ H3C 3J7, Canada.
   [Prentki, Marc] Univ Montreal, Dept Nutr, Montreal, PQ H3C 3J7, Canada.
   [Prentki, Marc] Univ Montreal, Dept Biochem, Montreal, PQ H3C 3J7, Canada.
C3 Australian National University; Canberra Hospital; Australian National
   University; Rigshospitalet; University of Copenhagen; Copenhagen
   University Hospital; Universite de Montreal; Universite de Montreal;
   Universite de Montreal; Universite de Montreal
RP Nolan, CJ (corresponding author), Canberrra Hosp, Dept Endocrinol, POB 11, Woden, ACT 2606, Australia.
EM christopher.nolan@anu.edu.au
RI Prentki, Marc/LBI-2401-2024; Nolan, Christopher J/B-2026-2008
OI Nolan, Christopher J/0000-0002-6964-3819; Damm,
   Peter/0000-0002-2067-5246
FU Eli Lilly; GlaxoSmithKline; Merck Sharp Dhome; Norvartis; Servier; Novo
   Nordisk; Novo Nordisk Foundation
FX CJN has received speaker's fees from Eli Lilly, GlaxoSmithKline, Merck
   Sharp Dhome, Norvartis, and Servier, and PD and CJN from Novo Nordisk.
   MP declares that he has no conflicts of interest. We thank Viviane
   Delghingaro and Jee-Hye Kim for initial preparation of figures and
   Sharyn Wragg for her graphic design assistance. PD has received funding
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NR 140
TC 671
Z9 774
U1 1
U2 224
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0140-6736
EI 1474-547X
J9 LANCET
JI Lancet
PD JUL 9
PY 2011
VL 378
IS 9786
BP 169
EP 181
DI 10.1016/S0140-6736(11)60614-4
PG 13
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 795CJ
UT WOS:000292948800034
PM 21705072
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Kuzawa, CW
   Quinn, EA
AF Kuzawa, Christopher W.
   Quinn, Elizabeth A.
TI Developmental Origins of Adult Function and Health: Evolutionary
   Hypotheses
SO ANNUAL REVIEW OF ANTHROPOLOGY
SE Annual Review of Anthropology
LA English
DT Review; Book Chapter
DE developmental plasticity; adaptation; fetal growth; DOHaD; reproduction;
   life history
ID PREDICTIVE ADAPTIVE RESPONSE; BIRTH-WEIGHT; FETAL ORIGINS; LIFE-HISTORY;
   THRIFTY PHENOTYPE; METABOLIC SYNDROME; BLOOD-PRESSURE;
   DIABETES-MELLITUS; PLASTICITY; GROWTH
AB Many biological systems have critical periods that overlap with the age of maternal provisioning via placenta or lactation. As such, they serve as conduits for phenotypic information transfer between generations and link. maternal experience with offspring biology and disease outcomes. This review critically evaluates proposals for an adaptive function of these responses in humans. Although most models assume an adult function for the metabolic responses to nutritional stress, these specific traits have more likely been tailored for effects during fetal life and infancy. Other biological functions are under stronger evolutionary selection later in life, and thus are better candidates for predictive plasticity. Given the long, human life cycle and environmental changes that are impredictable on decadal timescales, plastic responses that evolved to confer benefits in adolescence or adulthood likely rely on cues that integrate matrilineal experiences prior to gestation. We conclude with strategies for test testing the timescale and adaptive significance of developmental responses to early environments.
C1 [Kuzawa, Christopher W.; Quinn, Elizabeth A.] Northwestern Univ, Dept Anthropol, Evanston, IL 60208 USA.
C3 Northwestern University
RP Kuzawa, CW (corresponding author), Northwestern Univ, Dept Anthropol, Evanston, IL 60208 USA.
EM kuzawa@northwestern.edu
OI Quinn, Elizabeth A./0000-0001-7212-8271
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NR 103
TC 173
Z9 220
U1 0
U2 45
PU ANNUAL REVIEWS
PI PALO ALTO
PA 4139 EL CAMINO WAY, PO BOX 10139, PALO ALTO, CA 94303-0139 USA
SN 0084-6570
EI 1545-4290
J9 ANNU REV ANTHROPOL
JI Annu. Rev. Anthropol.
PY 2009
VL 38
BP 131
EP 147
DI 10.1146/annurev-anthro-091908-164350
PG 17
WC Anthropology
WE Book Citation Index – Social Sciences & Humanities (BKCI-SSH); Social Science Citation Index (SSCI)
SC Anthropology
GA 510NO
UT WOS:000271095800010
DA 2025-06-11
ER

PT J
AU Abbasi, A
   Corpeleijn, E
   Gansevoort, RT
   Gans, ROB
   Struck, J
   Schulte, J
   Hillege, HL
   van der Harst, P
   Stolk, RP
   Navis, G
   Bakker, SJL
AF Abbasi, Ali
   Corpeleijn, Eva
   Gansevoort, Ron T.
   Gans, Rijk O. B.
   Struck, Joachim
   Schulte, Janin
   Hillege, Hans L.
   van der Harst, Pim
   Stolk, Ronald P.
   Navis, Gerjan
   Bakker, Stephan J. L.
TI Circulating peroxiredoxin 4 and type 2 diabetes risk: the Prevention of
   Renal and Vascular Endstage Disease (PREVEND) study
SO DIABETOLOGIA
LA English
DT Article
DE Epidemiology; Peroxiredoxin 4; Risk prediction; Sex difference; Type 2
   diabetes
ID INSULIN-RESISTANCE; OXIDATIVE STRESS; CARDIOVASCULAR-DISEASE;
   PREDICTION; BIOMARKERS; GLUCOSE; IV; MORTALITY; PROTECTS; MELLITUS
AB Aims/hypothesis Oxidative stress plays a key role in the development of type 2 diabetes mellitus. We previously showed that the circulating antioxidant peroxiredoxin 4 (Prx4) is associated with cardiometabolic risk factors. We aimed to evaluate the association of Prx4 with type 2 diabetes risk in the general population.
   Methods We analysed data on 7,972 individuals from the Prevention of Renal and Vascular End-stage Disease (PREVEND) study (49% men, aged 28-75 years) with no diabetes at baseline. Logistic regression models adjusted for age, sex, smoking, waist circumference, hypertension and family history of diabetes were used to estimate the ORs for type 2 diabetes.
   Results During a median follow up of 7.7 years, 496 individuals (288 men; 58%) developed type 2 diabetes. The median (Q1-Q3) Prx4 level was 0.84 (0.53-1.40) U/1 in individuals who developed type 2 diabetes and 0.68 (0.43-1.08) U/1 in individuals who did not develop type 2 diabetes. For every doubling of Prx4 levels, the adjusted OR (95% CI) for type 2 diabetes was 1.16 (1.05-1.29) in the whole population; by sex, it was 1.31 (1.14-1.50) for men and 1.03 (0.87-1.21) for women. Further adjustment for other clinical measures did not materially change the results. The addition of Prx4 to a validated diabetes risk score significantly improved the prediction of type 2 diabetes in men (p = 0.002 for reclassification improvement).
   Conclusions/interpretation Our findings suggest that elevated serum Prx4 levels are associated with a higher risk of incident type 2 diabetes. For men, taking Prx4 into consideration can improve type 2 diabetes prediction over a validated diabetes risk score; in contrast, there is no improvement in risk prediction for women.
C1 [Abbasi, Ali] Univ Cambridge, Sch Clin Med, Addenbrookes Hosp, Inst Metab Sci,MRC Epidemiol Unit, Cambridge CB2 0QQ, England.
   [Abbasi, Ali; Corpeleijn, Eva; Hillege, Hans L.; Stolk, Ronald P.] Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, Groningen, Netherlands.
   [Abbasi, Ali; Gansevoort, Ron T.; Gans, Rijk O. B.; Navis, Gerjan; Bakker, Stephan J. L.] Univ Groningen, Univ Med Ctr Groningen, Dept Internal Med, Groningen, Netherlands.
   [Schulte, Janin] BRAHMS GmbH, Dept Res, Hennigsdorf, Germany.
   [van der Harst, Pim] Univ Groningen, Univ Med Ctr Groningen, Dept Cardiol, Groningen, Netherlands.
   [van der Harst, Pim] Univ Groningen, Univ Med Ctr Groningen, Dept Genet, Groningen, Netherlands.
   [van der Harst, Pim] Netherlands Heart Inst, ICIN, Durrer Ctr Cardiogenet Res, Utrecht, Netherlands.
C3 Cambridge University Hospitals NHS Foundation Trust; Addenbrooke's
   Hospital; University of Cambridge; University of Groningen; University
   of Groningen; Thermo Fisher Scientific; Brahms AG; University of
   Groningen; University of Groningen
RP Abbasi, A (corresponding author), Univ Cambridge, Sch Clin Med, Addenbrookes Hosp, Inst Metab Sci,MRC Epidemiol Unit, Cambridge Biomed Campus, Cambridge CB2 0QQ, England.
EM ali.abbasi@mrc-epid.cam.ac.uk
RI Stolk, Ronald/B-2341-2013; van der Harst, Pim/HOH-5622-2023; Bakker,
   Stephan/J-4023-2015
OI Stolk, Ronald/0000-0002-0518-1205; Gans, Reinold/0000-0001-5481-2387;
   van der Harst, Pim/0000-0002-2713-686X; Corpeleijn,
   Eva/0000-0002-2974-3305; Bakker, Stephan/0000-0003-3356-6791
FU Medical Research Council UK [MC-U106179471]; Netherlands Heart
   Foundation; Dutch Diabetes Research Foundation; Dutch Kidney Foundation;
   PREDICCt [01C-104-07]; Netherlands Organization for Scientific Research
   (NWO) [825.13.004]; MRC [MC_UU_12015/1] Funding Source: UKRI
FX This work is supported by the Medical Research Council UK (grant
   reference no. MC-U106179471), the Netherlands Heart Foundation, Dutch
   Diabetes Research Foundation and the Dutch Kidney Foundation. This
   research was performed within the framework of the Center for
   Translational Molecular Medicine (www.ctmm.nl), project PREDICCt (grant
   01C-104-07). A. Abbasi is supported by a Rubicon grant from the
   Netherlands Organization for Scientific Research (NWO project no.
   825.13.004).
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NR 43
TC 24
Z9 26
U1 0
U2 8
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0012-186X
EI 1432-0428
J9 DIABETOLOGIA
JI Diabetologia
PD SEP
PY 2014
VL 57
IS 9
BP 1842
EP 1849
DI 10.1007/s00125-014-3278-9
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA AM7MG
UT WOS:000340050800014
PM 24893865
OA Green Submitted, hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Castañeda, D
   Gabani, M
   Choi, SK
   Nguyen, QM
   Chen, C
   Mapara, A
   Kassan, A
   Gonzalez, AA
   Ait-Aissa, K
   Kassan, M
AF Castaneda, Diana
   Gabani, Mohanad
   Choi, Soo-Kyoung
   Quynh My Nguyen
   Chen, Cheng
   Mapara, Ayesha
   Kassan, Adam
   Gonzalez, Alexis A.
   Ait-Aissa, Karima
   Kassan, Modar
TI Targeting Autophagy in Obesity-Associated Heart Disease
SO OBESITY
LA English
DT Review
ID SUDDEN CARDIAC DEATH; OXIDATIVE STRESS; STIMULATES AUTOPHAGY;
   CARDIOVASCULAR RISK; ATRIAL-FIBRILLATION; METABOLIC SYNDROME; BECLIN 1;
   HYPERTROPHY; FAILURE; SYSTEM
AB Over the past three decades, the increasing rates of obesity have led to an alarming obesity epidemic worldwide. Obesity is associated with an increased risk of cardiovascular diseases; thus, it is essential to define the molecular mechanisms by which obesity affects heart function. Individuals with obesity and overweight have shown changes in cardiac structure and function, leading to cardiomyopathy, hypertrophy, atrial fibrillation, and arrhythmia. Autophagy is a highly conserved recycling mechanism that delivers proteins and damaged organelles to lysosomes for degradation. In the hearts of patients and mouse models with obesity, this process is impaired. Furthermore, it has been shown that autophagy flux restoration in obesity models improves cardiac function. Therefore, autophagy may play an important role in mitigating the adverse effects of obesity on the heart. Throughout this review, we will discuss the benefits of autophagy on the heart in obesity and how regulating autophagy might be a therapeutic tool to reduce the risk of obesity-associated cardiovascular diseases.
C1 [Castaneda, Diana] Calif State Univ Los Angeles, Dept Biol Sci, Los Angeles, CA 90032 USA.
   [Gabani, Mohanad; Ait-Aissa, Karima; Kassan, Modar] Univ Iowa, Carver Coll Med, Abboud Cardiovasc Res Ctr, Cardiovasc Div,Dept Med, Iowa City, IA 52242 USA.
   [Choi, Soo-Kyoung] Yonsei Univ, Dept Physiol, Coll Med, Brain Korea PLUS Project Med Sci 21, Seoul, South Korea.
   [Quynh My Nguyen] Univ Calif San Diego, Skaggs Sch Pharm & Pharmaceut Sci, La Jolla, CA 92093 USA.
   [Chen, Cheng] Shanghai Jiao Tong Univ, Sch Med, Shanghai Gen Hosp, Dept Emergency & Crit Care, Shanghai, Peoples R China.
   [Mapara, Ayesha] NE Illinois Univ, Dept Biol, Chicago, IL 60625 USA.
   [Kassan, Adam] West Coast Univ, Sch Pharm, Los Angeles, CA USA.
   [Gonzalez, Alexis A.] Pontificia Univ Catolica Valparaiso, Inst Quim, Valparaiso, Chile.
C3 California State University System; California State University Los
   Angeles; University of Iowa; Yonsei University; Yonsei University Health
   System; University of California System; University of California San
   Diego; Shanghai Jiao Tong University; Northeastern Illinois University;
   Pontificia Universidad Catolica de Valparaiso
RP Ait-Aissa, K; Kassan, M (corresponding author), Univ Iowa, Carver Coll Med, Abboud Cardiovasc Res Ctr, Cardiovasc Div,Dept Med, Iowa City, IA 52242 USA.
EM karima-ait-aissa@uiowa.edu; modar-kassan@uiowa.edu
RI Choi, Sookyoung/ISA-0668-2023
OI Gonzalez, Alexis A/0000-0003-0323-1448; Ait Aissa,
   Karima/0000-0002-7133-4767; Choi, Soo-Kyoung/0000-0002-7115-6358
FU NIGMS Division of Training, Workforce Development, and Diversity (TWD)
   Rise award [R25 GM061331]; Basic Science Research Program of the
   National Research Foundation of Korea (NRF) [NRF-2018R1D1A1B07041820];
   American Heart Association [18CDA34030155]; American Heart Association
   (AHA) [18CDA34030155] Funding Source: American Heart Association (AHA)
FX DC is supported by the NIGMS Division of Training, Workforce
   Development, and Diversity (TWD) Rise award R25 GM061331, SKC by the
   Basic Science Research Program of the National Research Foundation of
   Korea (NRF) (NRF-2018R1D1A1B07041820), and MK by the American Heart
   Association (18CDA34030155).
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NR 94
TC 23
Z9 25
U1 1
U2 14
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1930-7381
EI 1930-739X
J9 OBESITY
JI Obesity
PD JUL
PY 2019
VL 27
IS 7
BP 1050
EP 1058
DI 10.1002/oby.22455
PG 9
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA IE9BS
UT WOS:000472669700005
PM 30938942
DA 2025-06-11
ER

PT J
AU Park, JH
   Byeon, HK
   Park, KN
   Kim, JW
   Lee, SW
   Han, KD
   Chang, JW
   Kim, WS
   Koh, YW
   Ban, MJ
AF Park, Jae Hong
   Byeon, Hyung Kwon
   Park, Ki Nam
   Kim, Jae Wook
   Lee, Seung Won
   Han, Kyung-do
   Chang, Jae Won
   Kim, Won Shik
   Koh, Yoon Woo
   Ban, Myung Jin
TI Epidemiological association of olfactory dysfunction with hearing loss
   and dysphonia in the Korean population A cross-sectional study
SO MEDICINE
LA English
DT Article
DE hearing; olfaction; surveys and questionnaires; voice
ID NUTRITION EXAMINATION SURVEY; NATIONAL-HEALTH; DISORDERS; HYPOSMIA
AB The aim of the study is to investigate the association between olfactory dysfunction (OD), hearing loss, and dysphonia.
   The cross-sectional data for 17,984 adults who completed the Korea National Health and Nutrition Examination Surveys (2010 - 12) were analyzed. OD, hearing loss, and dysphonia were assessed using self-reporting questionnaires. The association of OD with hearing loss and dysphonia was evaluated.
   Hearing loss and dysphonia were significantly more prevalent in patients with OD than in those without OD (hearing loss, 28.1% vs 11.3%; dysphonia, 11.1% vs 5.9%; both P<.0001). After adjusting for confounders, including mental stress and metabolic syndrome, the risk of OD was significantly associated with hearing loss and dysphonia, and was greater in those with combined hearing loss and dysphonia than in both patients without these dysfunctions and in those with a single dysfunction (odds ratio 3.115, 95% confidence interval 1.973-4.917).
   OD was significantly associated with hearing loss and dysphonia.
C1 [Park, Jae Hong; Ban, Myung Jin] Soonchunhyang Univ, Coll Med, Dept Otorhinolaryngol Head & Neck Surg, Cheonan, South Korea.
   [Byeon, Hyung Kwon; Kim, Won Shik; Koh, Yoon Woo] Yonsei Univ, Coll Med, Dept Otorhinolaryngol, Seoul, South Korea.
   [Park, Ki Nam; Lee, Seung Won] Soonchunhyang Univ, Coll Med, Dept Otorhinolaryngol Head & Neck Surg, Bucheon, South Korea.
   [Kim, Jae Wook] Soonchunhyang Univ, Coll Med, Dept Otorhinolaryngol Head & Neck Surg, Seoul, South Korea.
   [Han, Kyung-do] Catholic Univ Korea, Coll Med, Dept Biostat, Seoul, South Korea.
   [Chang, Jae Won] Chungnam Natl Univ, Coll Med, Dept Otorhinolaryngol, Daejeon, South Korea.
   [Ban, Myung Jin] Yonsei Univ, Dept Med, Grad Sch, Seoul, South Korea.
C3 Soonchunhyang University; Yonsei University; Yonsei University Health
   System; Soonchunhyang University; Soonchunhyang University; Catholic
   University of Korea; Chungnam National University; Yonsei University
RP Ban, MJ (corresponding author), Soonchunhyang Univ, Coll Med, Dept Otorhinolaryngol Head & Neck Surg, 31,Suncheonhyang 6 Gil, Cheonan Si 330721, Chungcheongnam, South Korea.
EM mjbanent@gmail.com
RI Chang, Jae/R-3511-2019; Han, Kyungdo/JKH-7628-2023; Kim,
   Won/E-5403-2016; Ban, Myung Jin/B-4619-2016
OI Ban, Myung Jin/0000-0003-2069-2422
FU Soonchunhyang University Research Fund
FX This work was supported by the Soonchunhyang University Research Fund.
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NR 21
TC 9
Z9 9
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD NOV
PY 2017
VL 96
IS 47
AR e8890
DI 10.1097/MD.0000000000008890
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA FP5FP
UT WOS:000417645700109
PM 29382018
OA Green Published
DA 2025-06-11
ER

PT J
AU De La Brassinne, M
   Failla, V
   Nikkels, AF
AF de la Brassinne, M.
   Failla, V
   Nikkels, A. F.
TI PSORIASIS: STATE OF THE ART 2013 Part I: Clinical, Historical,
   Epidemiological and Genetic aspects, Co-Morbidities and Pathogenesis
SO ACTA CLINICA BELGICA
LA English
DT Review
DE psoriasis; genetics; autoimmunity; inflammation; quality of life
ID CARDIOVASCULAR RISK; SUSCEPTIBILITY; POPULATION; THERAPY
AB Psoriasis affects about 2 to 3% of the caucasian population. It is a chronic inflammatory disease affecting predominantly the skin with the involvement of autoimmune mediated mechanisms. Typical pathogenic features include an increased renewal of epidermal keratinocytes, the enlargement of the germinating compartment, papillomatosis, altered epidermal differentiation, angiogenesis, lymphangiogenesis and inflammatory infiltration. Several types of psoriasis are distinguished and may be present simultaneously in some patients. Up to 20 candidate genes have been evidenced in psoriasis. Genetic variability explains different types of the disease and influences response to therapeutics. Furthermore, psoriasis is triggered or aggravated by infections, traumatisms, medications, stress, tobacco, alcohol and endocrine factors. Severe psoriasis is frequently associated with comorbidities as obesity, diabetes, metabolic syndrome and cardiovascular diseases. For this reason, the similar pathogenic mechanisms of psoriasis and other IMID's (immune Mediated Inflammatory Diseases) and the use of systemic treatments shared with other specialties, an updated vision of psoriasis for the internist is mandatory.
C1 [de la Brassinne, M.; Failla, V; Nikkels, A. F.] Univ Liege, CHU Sart Tilman, Dept Dermatol, B-4000 Liege, Belgium.
C3 University of Liege
EM af.nikkels@chu.ulg.ac.be
OI Nikkels, Arjen/0000-0001-5240-4806
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NR 50
TC 5
Z9 7
U1 1
U2 5
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1784-3286
EI 2295-3337
J9 ACTA CLIN BELG
JI Acta Clin. Belg.
PD NOV-DEC
PY 2013
VL 68
IS 6
BP 427
EP 432
DI 10.2143/ACB.3387
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 301RR
UT WOS:000330550100008
PM 24635330
DA 2025-06-11
ER

PT J
AU Menegazzo, L
   Albiero, M
   Avogaro, A
   Fadini, GP
AF Menegazzo, Lisa
   Albiero, Mattia
   Avogaro, Angelo
   Fadini, Gian Paolo
TI Endothelial progenitor cells in diabetes mellitus
SO BIOFACTORS
LA English
DT Review
DE regeneration; stem cells; bone marrow; cell therapy
ID NITRIC-OXIDE SYNTHASE; VASCULAR COMPLICATIONS; INSULIN-RESISTANCE;
   METABOLIC SYNDROME; OXIDATIVE STRESS; CARDIAC-FUNCTION; NATURAL-HISTORY;
   GROWTH-FACTOR; DYSFUNCTION; STEM
AB Diabetes mellitus is associated with an increased risk of cardiovascular disease due to its negative impact on the vascular endothelium. The damaged endothelium is repaired by resident cells also through the contribution of a population of circulating cells derived from bone marrow. These cells, termed endothelial progenitor cells (EPCs) are involved in maintaining endothelial homeostasis and contributes to the formation of new blood vessels with a process called postnatal vasculogenesis. The mechanisms whereby these cells allow for protection of the cardiovascular system are still unclear; nevertheless, consistent evidences have shown that impairment and reduction of EPCs are hallmark features of type 1 and type 2 diabetes. Therefore, EPC alterations might have a pathogenic role in diabetic complications, thus becoming a potential therapeutic target. In this review, EPC alterations will be examined in the context of macrovascular and microvascular complications of diabetes, highlighting their roles and functions in the progression of the disease. (c) 2012 International Union of Biochemistry and Molecular Biology, Inc.
C1 [Menegazzo, Lisa; Albiero, Mattia; Avogaro, Angelo; Fadini, Gian Paolo] Univ Padua, Dept Med, I-35100 Padua, Italy.
   [Menegazzo, Lisa; Albiero, Mattia; Avogaro, Angelo; Fadini, Gian Paolo] Venetian Inst Mol Med, Lab Expt Diabetol, Padua, Italy.
C3 University of Padua; Veneto Institute Molecular Medicine
RP Fadini, GP (corresponding author), Univ Padua Polyclin, Dipartimento Med, 8 Piano,Via Giustiniani 2, I-35100 Padua, Italy.
EM gianpaolofadini@hotmail.com
RI Fadini, Gian/M-4575-2019; Albiero, Mattia/AAG-4257-2019; Avogaro,
   Angelo/S-3808-2016
OI AVOGARO, ANGELO/0000-0002-1177-0516; FADINI, GIAN
   PAOLO/0000-0002-6510-2097; Albiero, Mattia/0000-0003-4142-9738
FU European Foundation for the Study of Diabetes (EFSD)
FX GPF is supported by a European Foundation for the Study of Diabetes
   (EFSD) grant fellowship.
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NR 97
TC 69
Z9 72
U1 2
U2 22
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0951-6433
EI 1872-8081
J9 BIOFACTORS
JI Biofactors
PD MAY-JUN
PY 2012
VL 38
IS 3
BP 194
EP 202
DI 10.1002/biof.1016
PG 9
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 956YX
UT WOS:000305126600003
PM 22488933
DA 2025-06-11
ER

PT J
AU Balabanova, L
   Bondarev, G
   Seitkalieva, A
   Son, O
   Tekutyeva, L
AF Balabanova, Larissa
   Bondarev, Georgii
   Seitkalieva, Aleksandra
   Son, Oksana
   Tekutyeva, Liudmila
TI Insights into Alkaline Phosphatase Anti-Inflammatory Mechanisms
SO BIOMEDICINES
LA English
DT Review
DE alkaline phosphatase; LPS-induced inflammation; TLR4-NF-kB signaling
   pathways; immune metabolism; pro-inflammatory metabolism; catabolic
   phenotype; mitochondrial biogenesis; oxidative phosphorylation;
   endocytosis; autophagy
ID NADPH OXIDASE; ENDOCYTOSIS; COLITIS; MITOCHONDRIA; MACROPHAGES; CELLS
AB Background: The endogenous ecto-enzyme and exogenously administered alkaline phosphatase (ALP) have been evidenced to significantly attenuate inflammatory conditions, including Toll-like receptor 4 (TLR4)-related signaling and cytokine overexpression, barrier tissue dysfunction and oxidative stress, and metabolic syndrome and insulin resistance, in experimental models of colitis, liver failure, and renal and cardiac ischemia-reperfusion injury. This suggests multiple mechanisms of ALP anti-inflammatory action that remain to be fully elucidated. Methods: Recent studies have contributed to a deeper comprehension of the role played by ALP in immune metabolism. This review outlines the established effects of ALP on lipopolysaccharide (LPS)-induced inflammation, including the neutralization of LPS and the modulation of purinergic signaling. Results: The additional mechanisms of anti-inflammatory activity of ALP observed in different pathologies are proposed. Conclusions: The anti-inflammatory pathways of ALP may include a scavenger receptor (CD36)-mediated activation of beta-oxidation and oxidative phosphorylation, caveolin-dependent endocytosis, and selective autophagy-dependent degradation.
C1 [Balabanova, Larissa; Seitkalieva, Aleksandra] Russian Acad Sci, GB Elyakov Pacific Inst Bioorgan Chem, Far Eastern Branch, Prospect 100 Letya Vladivostoka 152, Vladivostok 690022, Russia.
   [Balabanova, Larissa; Bondarev, Georgii; Seitkalieva, Aleksandra; Son, Oksana; Tekutyeva, Liudmila] Far Eastern Fed Univ, Adv Engn Sch, Inst Biotechnol Bioengn & Food Syst, Youth Res Lab Recombinant DNA Technol, 10 Ajax Bay, Vladivostok 690922, Russky Island, Russia.
C3 Russian Academy of Sciences; Elyakov Pacific Institute of Bioorganic
   Chemistry; Far Eastern Federal University
RP Balabanova, L (corresponding author), Russian Acad Sci, GB Elyakov Pacific Inst Bioorgan Chem, Far Eastern Branch, Prospect 100 Letya Vladivostoka 152, Vladivostok 690022, Russia.; Balabanova, L (corresponding author), Far Eastern Fed Univ, Adv Engn Sch, Inst Biotechnol Bioengn & Food Syst, Youth Res Lab Recombinant DNA Technol, 10 Ajax Bay, Vladivostok 690922, Russky Island, Russia.
EM balaban@piboc.dvo.ru; bondarevgeorgii22@gmail.com; sasha0788@inbox.ru;
   oksana_son@bk.ru; tekuteva.la@dvfu.ru
RI Bondarev, Georgii/LZH-9408-2025; Balabanova, Larissa/AAO-2209-2020;
   Seitkalieva, Alexandra/E-7459-2019
OI Balabanova, Larissa/0000-0001-9131-2496; , Georgii
   Bondarev/0009-0008-4743-1074; Seitkalieva, Alexandra/0000-0002-3431-8055
FU Ministry of Science and Higher Education of the Russian Federation; 
   [FZNS-2022-0015]
FX This research was funded by the Ministry of Science and Higher Education
   of the Russian Federation, FZNS-2022-0015.
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NR 87
TC 7
Z9 7
U1 4
U2 4
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2227-9059
J9 BIOMEDICINES
JI Biomedicines
PD NOV
PY 2024
VL 12
IS 11
AR 2502
DI 10.3390/biomedicines12112502
PG 16
WC Biochemistry & Molecular Biology; Medicine, Research & Experimental;
   Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Research & Experimental Medicine;
   Pharmacology & Pharmacy
GA N8J1W
UT WOS:001366722800001
PM 39595068
OA gold
DA 2025-06-11
ER

PT J
AU Mecacci, F
   Ottanelli, S
   Petraglia, F
AF Mecacci, Federico
   Ottanelli, Serena
   Petraglia, Felice
TI Mothers with HIP - The short term and long-term impact, what is new?
SO DIABETES RESEARCH AND CLINICAL PRACTICE
LA English
DT Review
ID GESTATIONAL DIABETES-MELLITUS; GLUCOSE-TOLERANCE TEST; BETA-CELL
   FUNCTION; INSULIN-RESISTANCE; RISK-FACTOR; METABOLIC SYNDROME;
   CARDIOVASCULAR-DISEASE; PREVIOUS HISTORY; PREGNANT-WOMEN; PREECLAMPSIA
AB Hyperglycemia is one of the most common medical conditions that women encounter during pregnancy and it is due to gestational diabetes (GDM) in the majority of cases (International Diabetes Federation, 2015) [1]. GDM is associated with a higher incidence of maternal morbidity in pregnancy in term of hypertensive disorders/preclampsia and higher rate of cesarean delivery but also with long-term risk of type 2 diabetes and cardiovascular disease. Pregnancy can therefore be considered a stress test; diagnosis of HIP can unmask a preexisting susceptibility and consequently a future risk for type 2 diabetes and can be a useful marker of future cardiovascular risk. Postpartum follow up provides an excellent opportunity to implement healthy lifestyle behaviors to prevent or delay the development of diabetes or cardiovascular disease. The aim of the current review is to focus on short and long term maternal morbidity of HIP. (C) 2018 Elsevier B.V. All rights reserved.
C1 [Mecacci, Federico; Ottanelli, Serena; Petraglia, Felice] Univ Florence, Careggi Univ Hosp, Dept Hlth Sci, Obstet & Gynecol, Florence, Italy.
C3 University of Florence; Azienda Ospedaliero Universitaria Careggi
RP Ottanelli, S (corresponding author), Univ Florence, Careggi Univ Hosp, Dept Hlth Sci, Obstet & Gynecol, Florence, Italy.
EM serenaotta@gmail.com
RI PETRAGLIA, Felice/D-4373-2019
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NR 73
TC 1
Z9 1
U1 0
U2 6
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0168-8227
EI 1872-8227
J9 DIABETES RES CLIN PR
JI Diabetes Res. Clin. Pract.
PD NOV
PY 2018
VL 145
BP 146
EP 154
DI 10.1016/j.diabres.2018.04.039
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA HD4ZE
UT WOS:000452536400019
PM 29730389
DA 2025-06-11
ER

PT J
AU Ramirez, JG
   O'Malley, EJ
   Ho, WSV
AF Ramirez, J. G.
   O'Malley, E. J.
   Ho, W. S. V.
TI Pro-contractile effects of perivascular fat in health and disease
SO BRITISH JOURNAL OF PHARMACOLOGY
LA English
DT Review
ID VASCULAR SMOOTH-MUSCLE; CORONARY ENDOTHELIAL FUNCTION; ADIPOSE-TISSUE
   DYSFUNCTION; NITRIC-OXIDE; PROTEIN-KINASE; CONCISE GUIDE;
   PROINFLAMMATORY PHENOTYPE; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   OXIDATIVE STRESS
AB Perivascular adipose tissue (PVAT) is now recognized as an active player in vascular homeostasis. The expansion of PVAT in obesity and its possible role in vascular dysfunction have attracted much interest. In terms of the regulation of vascular tone and blood pressure, PVAT has been shown to release vasoactive mediators, for instance, angiotensin peptides, reactive oxygen species, chemokines and cytokines. The secretory profile of PVAT is altered by obesity, hypertension and other cardiovascular diseases, leading to an imbalance between its pro-contractile and anti-contractile effects. PVAT adipocytes represent an important source of the mediators, but infiltrating immune cells may become more important under conditions of hypoxia and inflammation. This review describes recent advances in the effects of PVAT on the regulation of vascular tone, highlighting the evidence for a procontractile action in health and disease. The role of the endothelium, vascular smooth muscle, immune cells and probably perivascular nerves in PVAT function is also discussed.
C1 [Ramirez, J. G.; O'Malley, E. J.; Ho, W. S. V.] St Georges Univ London, Vasc Biol Res Ctr, Cranmer Terrace, London SW17 0RE, England.
C3 City St Georges, University of London; St Georges University London
RP Ho, WSV (corresponding author), St Georges Univ London, Vasc Biol Res Ctr, Cranmer Terrace, London SW17 0RE, England.
EM vho@sgul.ac.uk
OI Ho, Wing/0000-0002-6065-6277
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NR 121
TC 44
Z9 49
U1 0
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0007-1188
EI 1476-5381
J9 BRIT J PHARMACOL
JI Br. J. Pharmacol.
PD OCT
PY 2017
VL 174
IS 20
SI SI
BP 3482
EP 3495
DI 10.1111/bph.13767
PG 14
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA FH8WN
UT WOS:000411485800009
PM 28257140
OA Green Published, Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Charar, C
   Gruenbaum, Y
AF Charar, Chayki
   Gruenbaum, Yosef
TI Lamins and metabolism
SO CLINICAL SCIENCE
LA English
DT Review
DE cell cycle; insulin; laminopathies; lamins; metabolism; mTOR; nuclear
   organization
ID A-TYPE LAMINS; GILFORD-PROGERIA-SYNDROME; ACQUIRED PARTIAL
   LIPODYSTROPHY; FAMILIAL PARTIAL LIPODYSTROPHY; CHROMATIN ORGANIZATION;
   NUCLEAR-ENVELOPE; MITOCHONDRIAL DYSFUNCTION; MANDIBULOACRAL DYSPLASIA;
   OXIDATIVE STRESS; MOUSE MODEL
AB Lamins are nuclear intermediate filaments (IFs) with important roles in most nuclear activities, including nuclear organization and cell-cycle progression. Mutations in human lamins cause over 17 different diseases, termed laminopathies. Most of these diseases are autosomal dominant and can be roughly divided into four major groups: muscle diseases, peripheral neuronal diseases, accelerated aging disorders and metabolic diseases including Dunnigan type familial partial lipodystrophy (FLPD), acquired partial lipodystrophy (APL) and autosomal dominant leucodystrophy. Mutations in lamins are also associated with the metabolic syndrome (MS). Cells derived from patients suffering from metabolic laminopathies, as well as cells derived from the corresponding animal models, show a disruption of the mechanistic target of rapamycin (mTOR) pathway, abnormal autophagy, altered proliferative rate and down-regulation of genes that regulate adipogenesis. In addition, treating Hutchinson-Gilford progeria syndrome (HGPS) cells with the mTOR inhibitor rapamycin improves their fate. In this review, we will discuss the ways by which lamin genes are involved in the regulation of cell metabolism.
C1 [Charar, Chayki; Gruenbaum, Yosef] Hebrew Univ Jerusalem, Dept Genet, Alexander Silberman Inst Life Sci, IL-91904 Jerusalem, Israel.
C3 Hebrew University of Jerusalem
RP Charar, C; Gruenbaum, Y (corresponding author), Hebrew Univ Jerusalem, Dept Genet, Alexander Silberman Inst Life Sci, IL-91904 Jerusalem, Israel.
EM chayki18@gmail.com; gru@vms.huji.ac.il
FU Muscular Dystrophy Association [MDA233701]; Niedersachsen-Israeli
   Research Cooperation [ZN 2926]; German Israel Foundation [GIF
   1-223-2014]; Israel Science Foundation [785/15]
FX This work was supported by the Muscular Dystrophy Association [grant
   number MDA233701]; the Niedersachsen-Israeli Research Cooperation [grant
   number ZN 2926]; the German Israel Foundation [grant number GIF
   1-223-2014]; and the Israel Science Foundation [grant number 785/15].
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NR 63
TC 17
Z9 20
U1 0
U2 9
PU PORTLAND PRESS LTD
PI LONDON
PA CHARLES DARWIN HOUSE, 12 ROGER STREET, LONDON WC1N 2JU, ENGLAND
SN 0143-5221
EI 1470-8736
J9 CLIN SCI
JI Clin. Sci.
PD JAN 1
PY 2017
VL 131
IS 2
BP 105
EP 111
DI 10.1042/CS20160488
PG 7
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA EK9KO
UT WOS:000394243500001
PM 27974395
DA 2025-06-11
ER

PT J
AU Liu, M
   Xu, L
   Yin, LH
   Qi, Y
   Xu, YW
   Han, X
   Zhao, YY
   Sun, HJ
   Yao, JH
   Lin, Y
   Liu, KX
   Peng, JY
AF Liu, Min
   Xu, Lina
   Yin, Lianhong
   Qi, Yan
   Xu, Youwei
   Han, Xu
   Zhao, Yanyan
   Sun, Huijun
   Yao, Jihong
   Lin, Yuan
   Liu, Kexin
   Peng, Jinyong
TI Potent effects of dioscin against obesity in mice
SO SCIENTIFIC REPORTS
LA English
DT Article
ID FATTY LIVER-DISEASE; OXIDATIVE STRESS; NONALCOHOLIC STEATOHEPATITIS;
   SIGNALING PATHWAYS; INSULIN-RESISTANCE; METABOLIC SYNDROME; HEME
   OXYGENASE-1; AUTOPHAGY; PATHOGENESIS; ALPHA
AB The mechanisms of the natural product dioscin against non-alcoholic fatty liver disease (NAFLD) are unclear. Thus, the purpose of the present study was to further confirm its effects of prevention and then to elucidate the potential mechanisms underlying its activity in mice. High-fat diet (HFD)-induced C57BL/6J mice and ob/ob mice were used as the experimental models. Serum and hepatic biochemical parameters were determined, and the mRNA and protein expression levels were detected. The results indicated that dioscin alleviated body weight and liver lipid accumulation symptoms, increased oxygen consumption and energy expenditure, and improved the levels of serum and hepatic biochemical parameters. Further investigations revealed that dioscin significantly attenuated oxidative damage, suppressed inflammation, inhibited triglyceride and cholesterol synthesis, promoted fatty acid beta-oxidation, down-regulated MAPK phosphorylation levels, and induced autophagy to alleviate fatty liver conditions. Dioscin prevents diet induced obesity and NAFLD by increasing energy expenditure. This agent should be developed as a new candidate for obesity and NAFLD prevention.
C1 [Liu, Min; Xu, Lina; Yin, Lianhong; Qi, Yan; Xu, Youwei; Han, Xu; Zhao, Yanyan; Sun, Huijun; Yao, Jihong; Lin, Yuan; Liu, Kexin; Peng, Jinyong] Dalian Med Univ, Coll Pharm, Dalian 116044, Peoples R China.
   [Peng, Jinyong] Dalian Med Univ, Res Inst Integrated Tradit & Western Med, Dalian 116044, Peoples R China.
C3 Dalian Medical University; Dalian Medical University
RP Peng, JY (corresponding author), Dalian Med Univ, Coll Pharm, Western 9 Lvshunnan Rd, Dalian 116044, Peoples R China.
EM jinyongpeng2008@126.com
RI qi, Yan/KIC-1612-2024; Liu, Kexin/GQH-0970-2022
FU Doctorate in Higher Education Institutions of Ministry of Education
   [20122105110004]; Program for Liaoning Innovative Research Team in
   University [LT2013019]; Program for New Century Excellent Talents in
   University [NCET-11-1007]
FX This work was supported by the Doctorate in Higher Education
   Institutions of Ministry of Education (No. 20122105110004), the Program
   for Liaoning Innovative Research Team in University (LT2013019) and the
   Program for New Century Excellent Talents in University (NCET-11-1007).
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NR 58
TC 79
Z9 82
U1 0
U2 31
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD JAN 22
PY 2015
VL 5
AR 7973
DI 10.1038/srep07973
PG 10
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA AZ4BB
UT WOS:000348166200002
PM 25609476
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU La Padula, D
   Zavaglia, L
   Hamad, T
   Nocito, MC
   Aquila, S
   Avena, P
   Rago, V
AF La Padula, Davide
   Zavaglia, Lucia
   Hamad, Tarig
   Nocito, Marta C.
   Aquila, Saveria
   Avena, Paola
   Rago, Vittoria
TI Leptin effects: focusing on the relationship between obesity and male
   infertility
SO MINERVA ENDOCRINOLOGY
LA English
DT Review
DE Leptin; Obesity; Infertility; male
ID BODY-MASS INDEX; SIGNALING PATHWAYS; MOLECULAR-MECHANISMS; SPERM
   PARAMETERS; HUMAN PHYSIOLOGY; IN-VITRO; RECEPTOR; EXPRESSION; PROTEIN;
   ADIPOSITY
AB The human male infertility has several causes interconnected to improper lifestyles such as smoking, sedentarism, environmental factors, toxins accumulation and energy imbalances. All these factors contribute to the obesity accompanied metabolic syndrome and hormonal alterations in the leptin-ghrelin axis. The leptin (Lep) has many pleiotropic effects in several biological systems, directly on the peripheral tissues or through the central nervous system. Many studies suggest that Lep is a key player in gonadal functions beside its documented role in reproductive regulation; however, further investigations are still necessary to elucidate all the molecular pathways involved in these mechanisms. Keeping into account that increased Lep levels in obese men are positively correlated with altered sperm parameters and testicular oxidative stress, evidence refers to Lep as a potential link between obesity and male infertility. This review represents an updated version on the concept of the Lep roles in mediating the male reproductive functions in obese patients.
C1 [La Padula, Davide; Zavaglia, Lucia; Hamad, Tarig; Nocito, Marta C.; Aquila, Saveria; Avena, Paola; Rago, Vittoria] Univ Calabria, Dept Pharm Hlth & Nutrit Sci, Arcavacata Di Rende, Cosenza, Italy.
C3 University of Calabria
RP Rago, V (corresponding author), Univ Calabria, Dept Pharm Hlth & Nutrit Sci, Arcavacata Di Rende, Cosenza, Italy.
EM vittoria.rago@unical.it
RI Rago, Vittoria/AAE-5924-2020
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NR 102
TC 2
Z9 2
U1 2
U2 2
PU EDIZIONI MINERVA MEDICA
PI TURIN
PA CORSO BRAMANTE 83-85 INT JOURNALS DEPT., 10126 TURIN, ITALY
SN 2724-6507
EI 2724-6116
J9 MINERVA ENDOCRINOL
JI Minerva Endocrinol.
PD MAR
PY 2024
VL 49
IS 1
BP 100
EP 110
DI 10.23736/S2724-6507.22.03901-X
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA C3M3F
UT WOS:001288423400001
PM 36251021
DA 2025-06-11
ER

PT J
AU Petroff, AB
   Weir, RL
   Yates, CR
   Ng, JD
   Baudry, J
AF Petroff, Anna B.
   Weir, Rebecca L.
   Yates, Charles R.
   Ng, Joseph D.
   Baudry, Jerome
TI Sequential Dynamics of Stearoyl-CoA Desaturase-1(SCD1)/Ligand Binding
   and Unbinding Mechanism: A Computational Study
SO BIOMOLECULES
LA English
DT Article
DE stearoyl-CoA desaturase-1; delta-9 desaturase; membrane protein;
   molecular dynamics; desaturase; molecular modeling
ID SUBSTRATE-SPECIFICITY; FORCE-FIELD; DESATURASE-1; RESIDUES; COENZYME;
   INHIBITORS; MOLECULES; INSIGHTS; ENZYME; LIPIDS
AB Stearoyl-CoA desaturase-1 (SCD1 or delta-9 desaturase, D9D) is a key metabolic protein that modulates cellular inflammation and stress, but overactivity of SCD1 is associated with diseases, including cancer and metabolic syndrome. This transmembrane endoplasmic reticulum protein converts saturated fatty acids into monounsaturated fatty acids, primarily stearoyl-CoA into oleoyl-CoA, which are critical products for energy metabolism and membrane composition. The present computational molecular dynamics study characterizes the molecular dynamics of SCD1 with substrate, product, and as an apoprotein. The modeling of SCD1:fatty acid interactions suggests that: (1) SCD1:CoA moiety interactions open the substrate-binding tunnel, (2) SCD1 stabilizes a substrate conformation favorable for desaturation, and (3) SCD1:product interactions result in an opening of the tunnel, possibly allowing product exit into the surrounding membrane. Together, these results describe a highly dynamic series of SCD1 conformations resulting from the enzyme:cofactor:substrate interplay that inform drug-discovery efforts.</p>
C1 [Petroff, Anna B.; Ng, Joseph D.; Baudry, Jerome] Univ Alabama, Dept Biol Sci, Huntsville, AL 35899 USA.
   [Weir, Rebecca L.] Univ Tennessee, Dept Biochem & Cellular & Mol Biol, Knoxville, TN 37996 USA.
   [Yates, Charles R.] Univ Mississippi, Sch Pharm, Natl Ctr Nat Prod Res, Oxford, MS 38677 USA.
C3 University of Alabama System; University of Alabama Huntsville;
   University of Tennessee System; University of Tennessee Knoxville;
   University of Mississippi
RP Baudry, J (corresponding author), Univ Alabama, Dept Biol Sci, Huntsville, AL 35899 USA.
EM rebeccaweir12@gmail.com; cryates2@olemiss.edu
RI Ng, Joseph/J-5764-2016
OI Weir, Rebecca/0000-0002-4323-7572
FU University of Alabama in Huntsville, Department of Biological Sciences;
   University of Tennessee; University of Mississippi
FX A.B.P., J.D.N. and J.B. are supported by the University of Alabama in
   Huntsville, Department of Biological Sciences. R.L.W. is supported by
   the University of Tennessee. C.R.Y. is supported by the University of
   Mississippi.
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NR 39
TC 2
Z9 2
U1 0
U2 18
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2218-273X
J9 BIOMOLECULES
JI Biomolecules
PD OCT
PY 2021
VL 11
IS 10
AR 1435
DI 10.3390/biom11101435
PG 13
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA WN4AD
UT WOS:000711711700001
PM 34680068
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Wang, Q
   Hu, JY
   Liu, YR
   Li, JJ
   Liu, BB
   Li, MM
   Lou, SJ
AF Wang, Qian
   Hu, Jingyun
   Liu, Yuran
   Li, Jingjing
   Liu, Beibei
   Li, Mingming
   Lou, Shujie
TI Aerobic Exercise Improves Synaptic-Related Proteins of Diabetic Rats by
   Inhibiting FOXO1/NF-κB/NLRP3 Inflammatory Signaling Pathway and
   Ameliorating PI3K/Akt Insulin Signaling Pathway
SO JOURNAL OF MOLECULAR NEUROSCIENCE
LA English
DT Article
DE Aerobic exercise; Synaptic proteins; Diabetes; Prefrontal cortex;
   Inflammation; Insulin signal
ID HIGH-FAT-DIET; ALZHEIMERS-DISEASE; COGNITIVE DEFICITS;
   PHYSICAL-EXERCISE; MAMMALIAN TARGET; OXIDATIVE STRESS; MTOR PATHWAY;
   AMYLOID-BETA; BRAIN; PLASTICITY
AB Diabetes mellitus is metabolic syndrome and a risk factor for cognitive dysfunction-related diseases such as dementia, especially Alzheimer's disease (AD), which is associated with chronic inflammation and abnormal insulin signaling pathway. Exercise, a known potential therapy for diabetes, can also alleviate neurodegeneration. We evaluated the effects of aerobic exercise on inflammation and insulin signaling pathway in the prefrontal cortex of diabetic rats. Male SD rats were fed with a normal diet or a high-fat diet (HFD) for 8 weeks. Then, part of the HFD rats was selected for aerobic exercise training. Our results show that aerobic exercise can improve the expression of synaptic plasticity-related proteins and reduce the phosphorylation of Tau by inhibiting the inflammatory signaling pathway and ameliorating the insulin signaling pathway in diabetic rats.
C1 [Wang, Qian; Hu, Jingyun; Liu, Yuran; Li, Jingjing; Liu, Beibei; Li, Mingming; Lou, Shujie] Shanghai Univ Sport, Minist Educ, Key Lab Exercise & Hlth Sci, 399 Changhai Rd, Shanghai, Peoples R China.
   [Liu, Beibei] Weifang Med Coll, Clin Med Dept, 7166 Baotong West St, Weifang, Shandong, Peoples R China.
C3 Shanghai University of Sport; Ministry of Education - China; Shandong
   Second Medical University
RP Lou, SJ (corresponding author), Shanghai Univ Sport, Minist Educ, Key Lab Exercise & Hlth Sci, 399 Changhai Rd, Shanghai, Peoples R China.
EM shujielou319@163.com
RI hu, jingyun/LBH-0381-2024; sun, xuejun/A-5561-2010; Li,
   Tongyu/GQA-7514-2022; liu, bb/GXA-2527-2022
OI hu, jingyun/0000-0001-8912-7857
FU National Natural Science Foundations of China [81572241]; Shanghai Key
   Laboratory of Human Sports Competence Development and Maintenance
   (Shanghai University of Sport) [11DZ2261100]
FX This project was supported by the National Natural Science Foundations
   of China (No. 81572241) and Shanghai Key Laboratory of Human Sports
   Competence Development and Maintenance (Shanghai University of Sport)
   (No. 11DZ2261100).
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NR 74
TC 35
Z9 46
U1 0
U2 36
PU HUMANA PRESS INC
PI TOTOWA
PA 999 RIVERVIEW DRIVE SUITE 208, TOTOWA, NJ 07512 USA
SN 0895-8696
EI 1559-1166
J9 J MOL NEUROSCI
JI J. Mol. Neurosci.
PD SEP
PY 2019
VL 69
IS 1
BP 28
EP 38
DI 10.1007/s12031-019-01302-2
PG 11
WC Biochemistry & Molecular Biology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Neurosciences & Neurology
GA IQ2JH
UT WOS:000480574300003
PM 31111330
DA 2025-06-11
ER

PT J
AU Wijarnpreecha, K
   Panjawatanan, P
   Mousa, OY
   Cheungpasitporn, W
   Pungpapong, S
   Ungprasert, P
AF Wijarnpreecha, Karn
   Panjawatanan, Panadeekarn
   Mousa, Omar Y.
   Cheungpasitporn, Wisit
   Pungpapong, Surakit
   Ungprasert, Patompong
TI Heavy Coffee Consumption and Risk of Pancreatitis: A Systematic Review
   and Meta-Analysis
SO DIGESTIVE DISEASES AND SCIENCES
LA English
DT Review
DE Pancreatitis; Coffee; Caffeine; Meta-analysis
ID NATIONWIDE EPIDEMIOLOGIC SURVEY; METABOLIC SYNDROME; OXIDATIVE STRESS;
   ASSOCIATION; OBESITY; TOBACCO
AB Background/ObjectivesHeavy consumption of coffee may have a protective effect against pancreatitis although results from previous studies were inconsistent. This meta-analysis was conducted with the aim to summarize all available data.MethodsThis meta-analysis included observational studies that compared the risk of pancreatitis between heavy coffee-drinkers and individuals who were not heavy coffee-drinkers. Pooled risk ratios (RRs) and 95% confidence interval (CI) were calculated using a random-effect, generic inverse variance method.ResultsOut of 219 retrieved articles, four studies with 351,137 participants met the eligibility criteria and were included in the analysis. The risk of pancreatitis among heavy coffee-drinkers was significantly lower than individuals who were not heavy coffee-drinkers with the pooled RR of 0.78 (95% CI 0.67-0.91). The statistical heterogeneity between the studies was insignificant (I-2=0%).ConclusionsThis meta-analysis demonstrated a significantly decreased risk of pancreatitis among heavy coffee-drinkers. However, further investigations are still required to determine causality and potential clinical application.
C1 [Wijarnpreecha, Karn] Bassett Med Ctr, Dept Internal Med, One Atwell Rd, Cooperstown, NY 13326 USA.
   [Panjawatanan, Panadeekarn] Chiang Mai Univ, Fac Med, Dept Biochem, Chiang Mai, Thailand.
   [Wijarnpreecha, Karn; Mousa, Omar Y.; Pungpapong, Surakit] Mayo Clin, Coll Med, Div Gastroenterol & Hepatol, Jacksonville, FL 32224 USA.
   [Cheungpasitporn, Wisit] Univ Mississippi, Med Ctr, Div Nephrol, Dept Med, Jackson, MS 39216 USA.
   [Ungprasert, Patompong] Mahidol Univ, Siriraj Hosp, Fac Med, Dept Res & Dev,Clinical Epidemiol Unit, Bangkok, Thailand.
C3 Chiang Mai University; Mayo Clinic; University of Mississippi;
   University of Mississippi Medical Center; Mahidol University
RP Wijarnpreecha, K (corresponding author), Bassett Med Ctr, Dept Internal Med, One Atwell Rd, Cooperstown, NY 13326 USA.; Wijarnpreecha, K (corresponding author), Mayo Clin, Coll Med, Div Gastroenterol & Hepatol, Jacksonville, FL 32224 USA.
EM dr.karn.wi@gmail.com; p.ungprasert@gmail.com
RI Cheungpasitporn, Wisit/H-8194-2019; Wijarnpreecha, Karn/J-3296-2019;
   Panjawatanan, Panadeekarn/HRA-8711-2023; Mousa, Omar/AAE-6113-2020
OI Pungpapong, Surakit/0000-0001-6455-959X; Wijarnpreecha,
   Karn/0000-0002-6232-6343
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NR 28
TC 5
Z9 5
U1 2
U2 10
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0163-2116
EI 1573-2568
J9 DIGEST DIS SCI
JI Dig. Dis. Sci.
PD NOV
PY 2018
VL 63
IS 11
BP 3134
EP 3140
DI 10.1007/s10620-018-5214-1
PG 7
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA GX7RL
UT WOS:000447972900041
PM 30043284
DA 2025-06-11
ER

PT J
AU Ebenesan, P
   Jainu, M
AF Ebenesan, Priya
   Jainu, Mallika
TI Combined Therapy with Insulin and Vildagliptin causes Cardiac
   Dysfunction in Diabetic Rats
SO INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES
LA English
DT Article
DE Diabetes mellitus; insulin; vildagliptin; cardiac mitochondria;
   antioxidants; incretin
ID INCREASED OXIDATIVE STRESS; METABOLIC SYNDROME; ASSAY; ENZYME; GLP-1
AB There is a strong rationale for using incretin-based therapies with insulin. In particular, hypoglycaemia is the limiting factor in glycemic management of insulin-treated patients of type 2 diabetes mellitus. The present study aimed at gaining greater understanding of the progression of cardiovascular degeneration in diabetes mellitus under combined treatment with vildagliptin and insulin through various analyses on cardiac tissues such as triphenyl tetrazolium chloride dye test. Experimental diabetic rats exhibited significantly lower TCA cycle enzyme and antioxidant defence enzyme activities with a concomitant increase in lipid peroxidation of the heart tissue. Monotherapy with either vildagliptin or insulin prevented these alterations in the oxidative energy metabolism and restored the TCA cycle enzyme activities to near normal in alloxan diabetic rats whereas the combined therapy altered mitochondrial enzyme levels significantly. These findings suggested that the toxic effects of the combinatorial therapy could be attributed to an increased oxidative damage and altered mitochondrial energy production, which might lead to progression of cardiovascular disease.
C1 [Ebenesan, Priya] Bharathiar Univ, Ctr Res & Dev, Dept Biochem, Coimbatore 641046, Tamil Nadu, India.
   [Jainu, Mallika] Sri Siva Subramaniya Nadar Coll Engn, Dept Biomed Engn, Madras 603110, Tamil Nadu, India.
C3 Bharathiar University; SSN College of Engineering
RP Ebenesan, P (corresponding author), Bharathiar Univ, Ctr Res & Dev, Dept Biochem, Coimbatore 641046, Tamil Nadu, India.
EM priya_28122003@yahoo.co.in
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TC 2
Z9 2
U1 0
U2 3
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, 400059, INDIA
SN 0250-474X
EI 1998-3743
J9 INDIAN J PHARM SCI
JI Indian J. Pharm. Sci.
PD MAY-JUN
PY 2018
VL 80
IS 3
BP 575
EP 580
DI 10.4172/pharmaceutical-sciences.1000396
PG 6
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA GP0PG
UT WOS:000440512000025
OA Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Sadler, NC
   Webb-Robertson, BJM
   Clauss, TR
   Pounds, JG
   Corley, R
   Wright, AT
AF Sadler, Natalie C.
   Webb-Robertson, Bobbie-Jo M.
   Clauss, Therese R.
   Pounds, Joel G.
   Corley, Richard
   Wright, Aaron T.
TI High-Fat Diets Alter the Modulatory Effects of Xenobiotics on Cytochrome
   P450 Activities
SO CHEMICAL RESEARCH IN TOXICOLOGY
LA English
DT Article
ID ACTIVITY-BASED PROBES; INDUCED LIVER-INJURY; BILE-ACIDS; METABOLIC
   SYNDROME; PROTEOMICS DATA; GUT MICROBIOTA; QUANTITATIVE-ANALYSIS; NLRP3
   INFLAMMASOME; DRUG-INTERACTIONS; ACCURATE MASS
AB Cytochrome P450 monooxygenase (P450) enzymes metabolize critical endogenous chemicals and oxidize nearly all xenobiotics. Dysregulated P450 activities lead to altered capacity for drug metabolism and cellular stress. The effects of mixed exposures on P450 expression and activity are variable and elusive. A high-fat diet (HFD) is a common exposure that results in obesity and associated pathologies including hepatotoxicity. Herein, we report the effects of cigarette smoke on P450 activities of normal weight and HFD induced obese mice. Activity-based protein profiling results indicate that HFD mice had significantly decreased P450 activity, likely instigated by proinflammatory chemicals, and that P450 enzymes involved in detoxification, xenobiotic metabolism, and bile acid synthesis were effected by HFD and smoke interaction. Smoking increased activity of all lung P450 and coexposure to diet effected P450 2s1. We need to expand our understanding of common exposures coupled to altered P450 metabolism to enhance the safety and efficacy of therapeutic drug dosing.
C1 [Sadler, Natalie C.; Webb-Robertson, Bobbie-Jo M.; Clauss, Therese R.; Pounds, Joel G.; Corley, Richard; Wright, Aaron T.] Pacific Northwest Natl Lab, Chem Biol & Exposure Sci, Biol Sci Div, Richland, WA 99352 USA.
C3 United States Department of Energy (DOE); Pacific Northwest National
   Laboratory
RP Wright, AT (corresponding author), Pacific Northwest Natl Lab, Chem Biol & Exposure Sci, Biol Sci Div, Richland, WA 99352 USA.
EM Aaron.Wright@pnnl.gov
RI Webb-Robertson, Bobbie-Jo/K-8230-2019; Corley, Richard/AAM-3579-2021
OI Webb-Robertson, Bobbie-Jo/0000-0002-4744-2397; Corley,
   Richard/0000-0003-2877-9194; Wright, Aaron/0000-0002-3172-5253
FU US National Institutes of Health, National Institute of Environmental
   Health Sciences [P42 ES016465, U54 ES016015]; National Institute for
   General Medical Sciences [P41 GM103493]; US DOE [DE-AC05-76RL01830]
FX This research was supported by the US National Institutes of Health,
   National Institute of Environmental Health Sciences under Grant Nos. P42
   ES016465 and U54 ES016015. This work also used instrumentation and
   capabilities developed under support from the National Institute for
   General Medical Sciences (P41 GM103493). A portion of the research was
   performed in the Environmental Molecular Sciences Laboratory, a US
   Department of Energy Biological and Environmental Research national
   scientific user facility at Pacific Northwest National Laboratory
   (PNNL). PNNL is a multiprogram laboratory operated by Battelle for the
   US DOE under Contract No. DE-AC05-76RL01830.
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NR 65
TC 28
Z9 31
U1 1
U2 11
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0893-228X
EI 1520-5010
J9 CHEM RES TOXICOL
JI Chem. Res. Toxicol.
PD MAY
PY 2018
VL 31
IS 5
BP 308
EP 318
DI 10.1021/acs.chemrestox.8b00008
PG 11
WC Chemistry, Medicinal; Chemistry, Multidisciplinary; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Chemistry; Toxicology
GA GG9IF
UT WOS:000433013500005
PM 29688711
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Rolseth, V
   Luna, L
   Olsen, AK
   Suganthan, R
   Scheffler, K
   Neurauter, CG
   Esbensen, Y
   Kusnierczyk, A
   Hildrestrand, GA
   Graupner, A
   Andersen, JM
   Slupphaug, G
   Klungland, A
   Nilsen, H
   Bjorås, M
AF Rolseth, Veslemoy
   Luna, Luisa
   Olsen, Ann Karin
   Suganthan, Rajikala
   Scheffler, Katja
   Neurauter, Christine G.
   Esbensen, Ying
   Kusnierczyk, Anna
   Hildrestrand, Gunn A.
   Graupner, Anne
   Andersen, Jill M.
   Slupphaug, Geir
   Klungland, Arne
   Nilsen, Hilde
   Bjoras, Magnar
TI No cancer predisposition or increased spontaneous mutation frequencies
   in NEIL DNA glycosylases-deficient mice
SO SCIENTIFIC REPORTS
LA English
DT Article
ID ONE-ELECTRON OXIDATION; ESCHERICHIA-COLI; EXCISION-REPAIR; GENE
   MUTATION; IN-VITRO; LESIONS SPIROIMINODIHYDANTOIN; METABOLIC SYNDROME;
   GUANINE LESIONS; HUMAN GENOME; STRESS
AB Base excision repair (BER) is a major pathway for removal of DNA base lesions and maintenance of genomic stability, which is essential in cancer prevention. DNA glycosylases recognize and remove specific lesions in the first step of BER. The existence of a number of these enzymes with overlapping substrate specificities has been thought to be the reason why single knock-out models of individual DNA glycosylases are not cancer prone. In this work we have characterized DNA glycosylases NEIL1 and NEIL2 (Neil1(-/-)/Neil2(-/-)) double and NEIL1, NEIL2 and NEIL3 (Neil1(-/-)/Neil2(-/-)/Neil3(-/-)) triple knockout mouse models. Unexpectedly, our results show that these mice are not prone to cancer and have no elevated mutation frequencies under normal physiological conditions. Moreover, telomere length is not affected and there was no accumulation of oxidative DNA damage compared to wild-type mice. These results strengthen the hypothesis that the NEIL enzymes are not simply back-up enzymes for each other but enzymes that have distinct functions beyond canonical repair.
C1 [Rolseth, Veslemoy; Luna, Luisa; Suganthan, Rajikala; Neurauter, Christine G.; Hildrestrand, Gunn A.; Klungland, Arne; Bjoras, Magnar] Univ Oslo, Oslo Univ Hosp, Rikshosp, Dept Microbiol, POB 4950 Nydalen, N-0424 Oslo, Norway.
   [Esbensen, Ying; Nilsen, Hilde] Univ Oslo, Dept Clin Mol Biol, N-1474 Nordbyhagen, Norway.
   [Esbensen, Ying; Nilsen, Hilde] Akershus Univ Hosp, N-1474 Nordbyhagen, Norway.
   [Scheffler, Katja; Kusnierczyk, Anna; Slupphaug, Geir; Bjoras, Magnar] Norwegian Univ Sci & Technol, Inst Canc Res & Mol Med, N-7491 Trondheim, Norway.
   [Kusnierczyk, Anna; Slupphaug, Geir] Norwegian Univ Sci & Technol, Prote & Metabol Core Facil PROMEC, N-7491 Trondheim, Norway.
   [Olsen, Ann Karin; Graupner, Anne; Andersen, Jill M.] Ctr Environm Radioact CERAD CoE, Oslo, Norway.
   [Olsen, Ann Karin; Graupner, Anne; Andersen, Jill M.] Norwegian Inst Publ Hlth, Dept Mol Biol, Oslo, Norway.
C3 University of Oslo; National Hospital Norway; University of Oslo;
   University of Oslo; Norwegian University of Science & Technology (NTNU);
   Norwegian University of Science & Technology (NTNU); Norwegian Institute
   of Public Health (NIPH)
RP Rolseth, V; Luna, L; Bjorås, M (corresponding author), Univ Oslo, Oslo Univ Hosp, Rikshosp, Dept Microbiol, POB 4950 Nydalen, N-0424 Oslo, Norway.; Bjorås, M (corresponding author), Norwegian Univ Sci & Technol, Inst Canc Res & Mol Med, N-7491 Trondheim, Norway.
EM vesrol@ous-hf.no; luisa.luna@rr-research.no
RI Bjørås, Magnar/N-9286-2017; Slupphaug, Geir/AAN-3794-2020; Klungland,
   Arne/X-1233-2019
OI Slupphaug, Geir/0000-0002-7498-3500; Scheffler,
   Katja/0000-0002-1734-7807; Klungland, Arne/0000-0001-7274-3661; Olsen,
   Ann-Karin/0000-0003-3982-5213
FU Research Council of Norway; Centres of Excellence funding scheme
   [223268/F50]; Norwegian Cancer Society; South Eastern Norway Health
   Authority; National Institute of Health/National Institute of
   Environmental Health Sciences (NIEHS) [R44ES018017]
FX This project has been supported by the Research Council of Norway (KS
   and HN), and through its Centres of Excellence funding scheme, project
   number 223268/F50 (AKO, AG, JMA); The Norwegian Cancer Society (VR and
   GAH) and the South Eastern Norway Health Authority (HN, VR). MS analysis
   was performed by the Proteomics and Metabolomics Core Facility (PROMEC),
   NTNU, which is founded by the Faculty of Medicine at NTNU and Central
   Norway Regional Health authority. Costs associated with Prototype
   MutaFlow Kits were defrayed with a grant from the National Institute of
   Health/National Institute of Environmental Health Sciences (NIEHS; grant
   no. R44ES018017). The contents are solely the responsibility of the
   authors, and do not necessarily represent the official views of the
   NIEHS.
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NR 81
TC 35
Z9 40
U1 0
U2 9
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD JUN 29
PY 2017
VL 7
AR 4384
DI 10.1038/s41598-017-04472-4
PG 12
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA EY9QC
UT WOS:000404332100022
PM 28663564
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Wang, H
   Yang, YJ
   Qian, HY
   Zhang, Q
   Xu, H
   Li, JJ
AF Wang, Hong
   Yang, Yue-Jin
   Qian, Hai-Yan
   Zhang, Qian
   Xu, Hui
   Li, Jian-Jun
TI Resveratrol in cardiovascular disease: what is known from current
   research?
SO HEART FAILURE REVIEWS
LA English
DT Article
DE Resveratrol; Antioxidant; Cardiovascular disease; Sirtuin type 1;
   Adenosine monophosphate-activated protein kinase
ID ENDOTHELIAL PROGENITOR CELLS; ACTIVATED PROTEIN-KINASE; VENTRICULAR
   DIASTOLIC DYSFUNCTION; VITAMIN-E SUPPLEMENTATION; CALCIUM-CHANNEL
   BLOCKER; NITRIC-OXIDE PRODUCTION; RED WINE; OXIDATIVE STRESS;
   ESTROGEN-RECEPTOR; STEM-CELLS
AB Resveratrol is a well-known antioxidant that exists in grape skin/seed, red wine, and the root of Polygonum cuspidatum, a traditional Chinese and Japanese medicinal material. Studies have found that resveratrol has many interesting properties, including anti-carcinogenic properties, anti-microbial and antiviral effects, the ability to reverse dyslipidemia and obesity, the ability to attenuate hyperglycemia and hyperinsulinemia, and the ability to protect endothelial function. Heart failure is the final consequence of the majority of cardiovascular diseases, and resveratrol has been shown to directly attenuate heart contraction. The cardiovascular protective capacities of resveratrol are associated with multiple molecular targets and may lead to the development of novel therapeutic strategies for atherosclerosis, ischemia/reperfusion, metabolic syndrome, and heart failure. This article will mainly review recently published basic researches about the protective cardiovascular effects of resveratrol because these results may lead to the development of new clinical therapeutics in patients.
C1 [Wang, Hong; Yang, Yue-Jin; Qian, Hai-Yan; Zhang, Qian; Xu, Hui; Li, Jian-Jun] Chinese Acad Med Sci, Fuwai Hosp, Dept Cardiol, Ctr Coronary Heart Dis, Beijing 100037, Peoples R China.
   [Wang, Hong; Yang, Yue-Jin; Qian, Hai-Yan; Zhang, Qian; Xu, Hui; Li, Jian-Jun] Chinese Acad Med Sci, Cardiovasc Inst, Beijing 100037, Peoples R China.
   [Wang, Hong; Yang, Yue-Jin; Qian, Hai-Yan; Zhang, Qian; Xu, Hui; Li, Jian-Jun] Peking Union Med Coll, Beijing 100037, Peoples R China.
C3 Chinese Academy of Medical Sciences - Peking Union Medical College; Fu
   Wai Hospital - CAMS; Chinese Academy of Medical Sciences - Peking Union
   Medical College; Chinese Academy of Medical Sciences - Peking Union
   Medical College; Peking Union Medical College
RP Yang, YJ (corresponding author), Chinese Acad Med Sci, Fuwai Hosp, Dept Cardiol, Ctr Coronary Heart Dis, Beijing 100037, Peoples R China.
EM yangyjfw@yahoo.com.cn; ahqhy712@yahoo.com.cn
RI Chaozhe, Zhu/AAK-7737-2020
FU National Natural Science Foundation of China [81070169, 81000091]; China
   Health & Medical Development Foundation [2008-zhfj2]; Research Fund of
   Capital Medical Development [2007-2018]; Beijing Novel Program
   [2008B78]; China Post-doctoral Science Foundation [20100470010]
FX Yue-Jin Yang was supported by grants from National Natural Science
   Foundation of China [81070169], China Health & Medical Development
   Foundation [2008-zhfj2], and Research Fund of Capital Medical
   Development [2007-2018]. Hai-Yan Qian was supported by grants from
   National Natural Science Foundation of China [81000091] and Beijing
   Novel Program [2008B78]. Hong Wang was supported by grants from China
   Post-doctoral Science Foundation [20100470010].
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NR 137
TC 76
Z9 81
U1 0
U2 46
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1382-4147
EI 1573-7322
J9 HEART FAIL REV
JI Heart Fail. Rev.
PD MAY
PY 2012
VL 17
IS 3
BP 437
EP 448
DI 10.1007/s10741-011-9260-4
PG 12
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 925FQ
UT WOS:000302746600009
PM 21688187
DA 2025-06-11
ER

PT J
AU Cartwright, MJ
   Schlauch, K
   Lenburg, ME
   Tchkonia, T
   Pirtskhalava, T
   Cartwright, A
   Thomou, T
   Kirkland, JL
AF Cartwright, Mark J.
   Schlauch, Karen
   Lenburg, Marc E.
   Tchkonia, Tamara
   Pirtskhalava, Tamar
   Cartwright, Andrew
   Thomou, Thomas
   Kirkland, James L.
TI Aging, Depot Origin, and Preadipocyte Gene Expression
SO JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL
   SCIENCES
LA English
DT Article
DE Aging; Preadipocyte; Fat cell progenitor
ID FED AD-LIBITUM; ADIPOSE-TISSUE; ANATOMIC SITE; ADIPOCYTE PRECURSORS;
   METABOLIC SYNDROME; PROGENITOR CELLS; BODY-FAT; IN-VITRO; RAT;
   DIFFERENTIATION
AB Fat distribution changes with aging. Inherent changes in fat cell progenitors may contribute because fat cells turn over throughout life. To define mechanisms, gene expression was profiled in preadipocytes cultured from epididymal and perirenal depots of young and old rats. 8.4% of probe sets differed significantly between depots, particularly developmental genes. Only 0.02% differed with aging, despite using less stringent criteria than for comparing depots. Twenty-five genes selected based on fold change with aging were analyzed in preadipocytes from additional young, middle-aged, and old animals by polymerase chain reaction. Thirteen changed significantly with aging, 13 among depots, and 9 with both. Genes involved in inflammation, stress, and differentiation changed with aging, as occurs in fat tissue. Age-related changes were greater in perirenal than epididymal preadipocytes, consistent with larger declines in replication and adipogenesis in perirenal preadipocytes. Thus. age-related changes in preadipocyte gene expression differ among depots, potentially contributing to fat redistribution and dysfunction.
C1 [Tchkonia, Tamara; Pirtskhalava, Tamar; Thomou, Thomas; Kirkland, James L.] Mayo Clin, Robert & Arlene Kogod Ctr Aging, Rochester, MN 55905 USA.
   [Schlauch, Karen] Univ Nevada, Dept Biochem & Mol Biol, Reno, NV 89557 USA.
   [Cartwright, Mark J.; Tchkonia, Tamara; Pirtskhalava, Tamar; Cartwright, Andrew; Thomou, Thomas; Kirkland, James L.] Boston Univ, Dept Med, Boston, MA 02215 USA.
   [Schlauch, Karen; Lenburg, Marc E.] Boston Univ, Dept Genet & Genom, Boston, MA 02215 USA.
   [Lenburg, Marc E.] Boston Univ, Dept Pathol & Lab Med, Boston, MA 02215 USA.
C3 Mayo Clinic; Nevada System of Higher Education (NSHE); University of
   Nevada Reno; Boston University; Boston University; Boston University
RP Kirkland, JL (corresponding author), Mayo Clin, Robert & Arlene Kogod Ctr Aging, Guggenheim 7-42B,200 1st St SW, Rochester, MN 55905 USA.
EM kirkland.james@mayo.edu
RI Kirkland, James/F-9159-2016; Lenburg, Marc/B-8027-2008
OI Tchkonia, Tamar/0000-0003-4623-7145; Lenburg, Marc/0000-0002-5760-4708
FU National Institutes of Health [AG13925]; Noaber Foundation; Robert and
   Arlene Kogod Center on Aging
FX This work was supported by the National Institutes of Health (AG13925 to
   J.L.K.). the Noaber Foundation. and the Robert and Arlene Kogod Center
   on Aging.
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NR 54
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Z9 92
U1 1
U2 7
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1079-5006
EI 1758-535X
J9 J GERONTOL A-BIOL
JI J. Gerontol. Ser. A-Biol. Sci. Med. Sci.
PD MAR
PY 2010
VL 65
IS 3
BP 242
EP 251
DI 10.1093/gerona/glp213
PG 10
WC Geriatrics & Gerontology; Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA 567CV
UT WOS:000275420800005
PM 20106964
OA Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Vinik, AI
   Erbas, T
   Stansberry, KB
   Pittenger, GL
AF Vinik, AI
   Erbas, T
   Stansberry, KB
   Pittenger, GL
TI Small fiber neuropathy and neurovascular disturbances in diabetes
   mellitus
SO EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
LA English
DT Review
DE C-fibers; thermal perception; pain; autonomic; neurovascular dysfunction
ID ALPHA-LIPOIC ACID; LASER-DOPPLER FLOWMETRY; BLOOD-FLOW; PERIPHERAL
   NEUROPATHY; OXYGEN-TENSION; NERVE FUNCTION; HUMAN-SKIN;
   GLUCOSE-METABOLISM; OXIDATIVE STRESS; NITRIC-OXIDE
AB Functional and organic abnormalities in small unmyelinated C fibers are the hallmark of type 2 diabetes. These may be silent clinically or present with burning feet, neurovascular abnormalities, where-in warm, cold, and heat pain thresholds are disturbed in association with impairment in skin blood flow and loss of PGP 9.5 immunostaining nerves in the skin. There is a dysfunctional phase preceding organic structural damage to the neurovascular unit. It coexists with elements of the metabolic syndrome, particularly insulin resistance (IR), elevated systolic blood pressure, and diabetic dyslipidemia i.e. dysfunction of the neurovascular unit may contribute to IR due to compromised blood flow with decreased delivery of fuels to their target tissues. If this proves to be the case, it will become important to re-focus energies on the defective neuropeptidergic regulation of blood flow as an approach to ameliorating diabetes. Because there is a functional phase that precedes structural damage, reversibility of the defect is achievable.
C1 Eastern Virginia Med Sch, Strelitz Diabet Res Inst, Dept Med & Pathol Anat Neurobiol, Norfolk, VA 23510 USA.
C3 Eastern Virginia Medical School
RP Eastern Virginia Med Sch, Strelitz Diabet Inst, 855 W Brambleton Ave, Norfolk, VA 23510 USA.
RI ERBAS, AYSE/I-9256-2013
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PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
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EI 1439-3646
J9 EXP CLIN ENDOCR DIAB
JI Exp. Clin. Endocrinol. Diabet.
PY 2001
VL 109
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EP S473
DI 10.1055/s-2001-18602
PG 23
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 448RR
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PM 11460591
DA 2025-06-11
ER

PT J
AU Golubnitschaja, O
   Polivka, J 
   Potuznik, P
   Pesta, M
   Stetkarova, I
   Mazurakova, A
   Lackova, L
   Kubatka, P
   Kropp, M
   Thumann, G
   Erb, C
   Fröhlich, H
   Wang, W
   Baban, B
   Kapalla, M
   Shapira, N
   Richter, K
   Karabatsiakis, A
   Smokovski, I
   Schmeel, LC
   Gkika, E
   Paul, F
   Parini, P
   Polivka, J
AF Golubnitschaja, Olga
   Polivka, Jiri, Jr.
   Potuznik, Pavel
   Pesta, Martin
   Stetkarova, Ivana
   Mazurakova, Alena
   Lackova, Lenka
   Kubatka, Peter
   Kropp, Martina
   Thumann, Gabriele
   Erb, Carl
   Froehlich, Holger
   Wang, Wei
   Baban, Babak
   Kapalla, Marko
   Shapira, Niva
   Richter, Kneginja
   Karabatsiakis, Alexander
   Smokovski, Ivica
   Schmeel, Leonard Christopher
   Gkika, Eleni
   Paul, Friedemann
   Parini, Paolo
   Polivka, Jiri
TI The paradigm change from reactive medical services to 3PM in ischemic
   stroke: a holistic approach utilising tear fluid multi-omics,
   mitochondria as a vital biosensor and AI-based multi-professional data
   interpretation
SO EPMA JOURNAL
LA English
DT Article
DE Predictive preventive personalised medicine (PPPM; 3PM); Ischemic
   stroke; Sudden cardiac arrest; death; Suboptimal health;
   Health-to-disease transition; Primary and secondary care;
   Patient-friendly non-invasive approach; Tear fluid analysis; Viromics
   and metabolomics; Mitochondrial health; Mitophagy; Inflammation;
   Cytokine storm (COVID-19); Diabetes mellitus; Diabetic retinopathy;
   Flammer syndrome; Health risk assessment; Sleep medicine; Behavioural
   patterns; Individualised patient profile; Artificial intelligence;
   Population screening; Healthcare economy; Health policy; Expert
   recommendations
ID SILENT BRAIN INFARCTION; CEREBRAL INFARCTION; RISK-FACTORS;
   CARDIOVASCULAR-DISEASE; BREAST-CANCER; COGNITIVE IMPAIRMENT; PLASMA
   HOMOCYSTEINE; CLINICAL SYNDROMES; METABOLIC SYNDROME; ALZHEIMER-DISEASE
AB Worldwide stroke is the second leading cause of death and the third leading cause of death and disability combined. The estimated global economic burden by stroke is over US$891 billion per year. Within three decades (1990-2019), the incidence increased by 70%, deaths by 43%, prevalence by 102%, and DALYs by 143%. Of over 100 million people affected by stroke, about 76% are ischemic stroke (IS) patients recorded worldwide. Contextually, ischemic stroke moves into particular focus of multi-professional groups including researchers, healthcare industry, economists, and policy-makers. Risk factors of ischemic stroke demonstrate sufficient space for cost-effective prevention interventions in primary (suboptimal health) and secondary (clinically manifested collateral disorders contributing to stroke risks) care. These risks are interrelated. For example, sedentary lifestyle and toxic environment both cause mitochondrial stress, systemic low-grade inflammation and accelerated ageing; inflammageing is a low-grade inflammation associated with accelerated ageing and poor stroke outcomes. Stress overload, decreased mitochondrial bioenergetics and hypomagnesaemia are associated with systemic vasospasm and ischemic lesions in heart and brain of all age groups including teenagers. Imbalanced dietary patterns poor in folate but rich in red and processed meat, refined grains, and sugary beverages are associated with hyperhomocysteinaemia, systemic inflammation, small vessel disease, and increased IS risks. Ongoing 3PM research towards vulnerable groups in the population promoted by the European Association for Predictive, Preventive and Personalised Medicine (EPMA) demonstrates promising results for the holistic patient-friendly non-invasive approach utilising tear fluid-based health risk assessment, mitochondria as a vital biosensor and AI-based multi-professional data interpretation as reported here by the EPMA expert group. Collected data demonstrate that IS-relevant risks and corresponding molecular pathways are interrelated. For examples, there is an evident overlap between molecular patterns involved in IS and diabetic retinopathy as an early indicator of IS risk in diabetic patients. Just to exemplify some of them such as the 5-aminolevulinic acid/pathway, which are also characteristic for an altered mitophagy patterns, insomnia, stress regulation and modulation of microbiota-gut-brain crosstalk. Further, ceramides are considered mediators of oxidative stress and inflammation in cardiometabolic disease, negatively affecting mitochondrial respiratory chain function and fission/fusion activity, altered sleep-wake behaviour, vascular stiffness and remodelling. Xanthine/pathway regulation is involved in mitochondrial homeostasis and stress-driven anxiety-like behaviour as well as molecular mechanisms of arterial stiffness. In order to assess individual health risks, an application of machine learning (AI tool) is essential for an accurate data interpretation performed by the multiparametric analysis. Aspects presented in the paper include the needs of young populations and elderly, personalised risk assessment in primary and secondary care, cost-efficacy, application of innovative technologies and screening programmes, advanced education measures for professionals and general population-all are essential pillars for the paradigm change from reactive medical services to 3PM in the overall IS management promoted by the EPMA.
C1 [Golubnitschaja, Olga] Rhein Friedrich Wilhelms Univ Bonn, Univ Hosp Bonn, Dept Radiat Oncol, Predict Prevent & Personalised 3P Med, D-53127 Bonn, Germany.
   [Polivka, Jiri, Jr.] Charles Univ Prague, Fac Med Plzen, Dept Histol & Embryol, Prague, Czech Republic.
   [Polivka, Jiri, Jr.] Charles Univ Prague, Fac Med Plzen, Biomed Ctr, Prague, Czech Republic.
   [Potuznik, Pavel; Polivka, Jiri] Charles Univ Prague, Univ Hosp Plzen, Dept Neurol, Prague, Czech Republic.
   [Potuznik, Pavel; Polivka, Jiri] Charles Univ Prague, Fac Med Plzen, Prague, Czech Republic.
   [Pesta, Martin] Charles Univ Prague, Fac Med Plzen, Dept Biol, Prague, Czech Republic.
   [Stetkarova, Ivana] Charles Univ Prague, Univ Hosp Kralovske Vinohrady, Fac Med 3, Dept Neurol, Prague, Czech Republic.
   [Mazurakova, Alena] Comenius Univ, Jessenius Fac Med, Dept Anat, Martin, TN, Slovakia.
   [Lackova, Lenka; Kubatka, Peter] Comenius Univ, Jessenius Fac Med, Dept Histol & Embryol, Martin, TN, Slovakia.
   [Kropp, Martina; Thumann, Gabriele] Univ Geneva, Expt Ophthalmol, CH-1205 Geneva, Switzerland.
   [Kropp, Martina; Thumann, Gabriele] Univ Hosp Geneva, Dept Ophthalmol, CH-1205 Geneva, Switzerland.
   [Erb, Carl] Private Inst Appl Ophthalmol, Berlin, Germany.
   [Froehlich, Holger] Fraunhofer SCAI, Artificial Intelligence & Data Sci Grp, St Augustin, Germany.
   [Froehlich, Holger] Univ Bonn, Bonn Aachen Int Ctr IT B It, D-53115 Bonn, Germany.
   [Wang, Wei] Edith Cowan Univ, Perth, Australia.
   [Wang, Wei] Capital Med Univ, Beijing Municipal Key Lab Clin Epidemiol, Beijing, Peoples R China.
   [Baban, Babak] Augusta Univ, Med Coll Georgia, Dent Coll Georgia, Dept Neurol, Augusta, GA USA.
   [Baban, Babak] Augusta Univ, Med Coll Georgia, Dent Coll Georgia, Dept Surg, Augusta, GA USA.
   [Kapalla, Marko] Negentrop Syst, Ruzomberok, Slovakia.
   [Kapalla, Marko] PPPM Ctr Sro, Ruzomberok, Slovakia.
   [Shapira, Niva] Ashkelon Acad Coll, Sch Hlth Sci, Dept Nutr, Ashqelon, Israel.
   [Richter, Kneginja] CuraMed Tagesklin Nurnberg GmbH, Nurnberg, Germany.
   [Richter, Kneginja] Tech Hsch Nurnberg GSO, Nurnberg, Germany.
   [Richter, Kneginja] Paracelsus Med Univ, Univ Clin Psychiat & Psychotherapy, Nurnberg, Germany.
   [Karabatsiakis, Alexander] Univ Innsbruck, Dept Psychol, Clin Psychol 2, Innsbruck, Austria.
   [Smokovski, Ivica] Univ Goce Delcev, Fac Med Sci, Univ Clin Endocrinol Diabet & Metab Disorders Sko, Stip, North Macedonia.
   [Schmeel, Leonard Christopher; Gkika, Eleni] Rhein Friedrich Wilhelms Univ Bonn, Univ Hosp Bonn, Dept Radiat Oncol, D-53127 Bonn, Germany.
   [Paul, Friedemann] Charite Univ Med Berlin, Berlin, Germany.
   [Parini, Paolo] Karolinska Inst, Dept Med Huddinge, Cardio Metab Unit, Stockholm, Sweden.
   [Parini, Paolo] Karolinska Inst, Dept Lab Med, Stockholm, Sweden.
   Karolinska Univ Hosp, Med Unit Endocrinol Theme Inflammat & Ageing, Stockholm, Sweden.
C3 University of Bonn; Charles University Prague; Charles University
   Prague; University Hospital Plzen; Charles University Prague; Charles
   University Prague; Charles University Prague; University Hospital
   Vinohrady; Charles University Prague; Comenius University Bratislava;
   Comenius University Bratislava; University of Geneva; University of
   Geneva; Fraunhofer Gesellschaft; Fraunhofer Germany; Fraunhofer
   Institute Center Schloss Birlinghoven; University of Bonn; Edith Cowan
   University; Capital Medical University; University System of Georgia;
   Augusta University; University System of Georgia; Augusta University;
   University of Innsbruck; Goce Delcev University of Stip; University of
   Bonn; Berlin Institute of Health; Free University of Berlin; Humboldt
   University of Berlin; Charite Universitatsmedizin Berlin; Karolinska
   Institutet; Karolinska Institutet; Karolinska Institutet; Karolinska
   University Hospital
RP Golubnitschaja, O (corresponding author), Rhein Friedrich Wilhelms Univ Bonn, Univ Hosp Bonn, Dept Radiat Oncol, Predict Prevent & Personalised 3P Med, D-53127 Bonn, Germany.
EM Olga.Golubnitschaja@ukbonn.de
RI Smokovski, Ivica/GQH-0272-2022; Wang, Wei/C-4364-2019; Paul,
   Friedemann/ABF-9415-2020; Erb, Carl/H-7487-2019; Kapalla,
   Marko/AAE-7341-2020; Karabatsiakis, Alexander/AAY-7114-2020; Richter,
   Kneginja/N-3297-2017; Kropp, Martina/H-9260-2018; Frohlich,
   Holger/H-1976-2017
OI Potuznik, Pavel/0000-0001-8241-7798; Richter,
   Kneginja/0000-0003-0396-9530; Kropp, Martina/0000-0001-6861-5851;
   Frohlich, Holger/0000-0002-5328-1243; Parini, Paolo/0000-0002-6541-8542;
   Schmeel, Christopher/0000-0002-3901-4122; Smokovski,
   Ivica/0000-0001-6814-1748; Thumann, Gabriele/0000-0003-3682-9569; paul,
   friedemann/0000-0002-6378-0070
FU Projekt DEAL; European Association for Predictive, Preventive and
   Personalised Medicine, EPMA, Brussels; Cooperation Programme, research
   area MED/DIAG, Charles University; Ministry of Health of the Czech
   Republic - Conceptual Development of Research Organization (University
   Hospital Pilsen-FNPL) [00669806]; LHW Foundation, Liechtenstein
FX Open Access funding enabled and organized by Projekt DEAL. The
   cumulative research paper was supported by the following: The European
   Association for Predictive, Preventive and Personalised Medicine, EPMA,
   Brussels The Cooperation Programme, research area MED/DIAG, Charles
   University and by a grant from the Ministry of Health of the Czech
   Republic - Conceptual Development of Research Organization (University
   Hospital Pilsen-FNPL, 00669806) The LHW Foundation, Liechtenstein.
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NR 188
TC 26
Z9 26
U1 24
U2 49
PU SPRINGER INT PUBL AG
PI CHAM
PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND
SN 1878-5077
EI 1878-5085
J9 EPMA J
JI EPMA J.
PD MAR
PY 2024
VL 15
IS 1
BP 1
EP 23
DI 10.1007/s13167-024-00356-6
EA FEB 2024
PG 23
WC Medicine, General & Internal; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Research & Experimental Medicine
GA 0RF1P
UT WOS:001181836200001
PM 38463624
OA hybrid, Green Published
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Waldman, M
   Singh, SP
   Shen, HH
   Alex, R
   Rezzani, R
   Favero, G
   Hochhauser, E
   Kornowski, R
   Arad, M
   Peterson, SJ
AF Waldman, Maayan
   Singh, Shailendra P.
   Shen, Hsin-Hsueh
   Alex, Ragin
   Rezzani, Rita
   Favero, Gaia
   Hochhauser, Edith
   Kornowski, Ran
   Arad, Michael
   Peterson, Stephen J.
TI Silencing the Adipocytokine NOV: A Novel Approach to Reversing Oxidative
   Stress-Induced Cardiometabolic Dysfunction
SO CELLS
LA English
DT Article
DE oxidative stress; metabolic syndrome; CCN3; NOV; heme oxygenase; PGC-1;
   mitochondria; mitophagy; type 2 diabetes
ID EPICARDIAL ADIPOSE-TISSUE; ACTIVATED PROTEIN-KINASE; HEME OXYGENASE;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; HO-1 EXPRESSION;
   CARBON-MONOXIDE; OBESITY; AUTOPHAGY; LIVER
AB Objective: NOV/CCN3 is an adipocytokine recently linked to obesity, insulin resistance, and cardiometabolic dysfunction. NOV is manufactured and secreted from adipose tissue, with blood levels highly correlated with BMI. NOV levels are increased in obesity and a myriad of inflammatory diseases. Elevated NOV levels cause oxidative stress by increasing free radicals, decreasing antioxidants, and decreasing heme oxygenase (HO-1) levels, resulting in decreased vascular function. Silencing NOV in NOV knockout mice improved insulin sensitivity. We wanted to study how suppressing NOV expression in an obese animal model affected pathways and processes related to obesity, inflammation, and cardiometabolic function. This is the first study to investigate the interaction of adipose tissue-specific NOV/CCN3 and cardiometabolic function. Methods: We constructed a lentivirus containing the adiponectin-promoter-driven shNOV to examine the effect of NOV inhibition (shNOV) in adipose tissue on the heart of mice fed a high-fat diet. Mice were randomly divided into three groups (five per group): (1) lean (normal diet), (2) high-fat diet (HFD)+ sham virus, and (3) HFD + shNOV lentivirus. Blood pressure, tissue inflammation, and oxygen consumption were measured. Metabolic and mitochondrial markers were studied in fat and heart tissues. Results: Mice fed an HFD developed adipocyte hypertrophy, fibrosis, inflammation, and decreased mitochondrial respiration. Inhibiting NOV expression in the adipose tissue of obese mice by shNOV increased mitochondrial markers for biogenesis (PGC-1 alpha, the nuclear co-activator of HO-1) and functional integrity (FIS1) and insulin signaling (AKT). The upregulation of metabolic and mitochondrial markers was also evident in the hearts of the shNOV mice with the activation of mitophagy. Using RNA arrays, we identified a subgroup of genes that highly correlated with increased adipocyte mitochondrial autophagy in shNOV-treated mice. A heat map analysis in obese mice confirmed that the suppression of NOV overrides the genetic susceptibility of adiposity and the associated detrimental metabolic changes and correlates with the restoration of anti-inflammatory, thermogenic, and mitochondrial genes. Conclusion: Our novel findings demonstrate that inhibiting NOV expression improves adipose tissue function in a positive way in cardiometabolic function by inducing mitophagy and improving mitochondrial function by the upregulation of PGC-1 alpha, the insulin sensitivity signaling protein. Inhibiting NOV expression increases PGC-1, a key component of cardiac bioenergetics, as well as key signaling components of metabolic change, resulting in improved glucose tolerance, improved mitochondrial function, and decreased inflammation. These metabolic changes resulted in increased oxygen consumption, decreased adipocyte size, and improved cardiac metabolism and vascular function at the structural level. The crosstalk of the adipose tissue-specific deletion of NOV/CCN3 improved cardiovascular function, representing a novel therapeutic strategy for obesity-related cardiometabolic dysfunction.
C1 [Waldman, Maayan; Hochhauser, Edith] Tel Aviv Univ, Felsenstein Med Res Ctr, Sackler Sch Med, Cardiac Res Lab, IL-699780 Tel Aviv, Israel.
   [Singh, Shailendra P.; Shen, Hsin-Hsueh; Alex, Ragin] New York Med Coll, Dept Pharmacol, Valhalla, NY 10595 USA.
   [Singh, Shailendra P.] Cent Univ Rajasthan, Dept Sports Biosci, Kishangarh 305817, India.
   [Alex, Ragin] New York Med Coll, Dept Med, Valhalla, NY 10595 USA.
   [Rezzani, Rita; Favero, Gaia] Univ Brescia, Dept Clin & Expt Sci, Anat & Physiopathol Div, I-25123 Brescia, Italy.
   [Kornowski, Ran] Rabin Med Ctr, Dept Cardiol, IL-49100 Petah Tiqwa, Israel.
   [Arad, Michael] Sheba Med Ctr, Leviev Heart Ctr, Tel Hashomer, Israel.
   [Arad, Michael] Tel Aviv Univ, Sackler Sch Med, IL-699780 Tel Aviv, Israel.
   [Peterson, Stephen J.] Weill Cornell Med, Dept Med, New York, NY 10021 USA.
   [Peterson, Stephen J.] New York Presbyterian Brooklyn Methodist Hosp, Dept Med, Brooklyn, NY 11215 USA.
C3 Tel Aviv University; Sackler Faculty of Medicine; New York Medical
   College; Central University of Rajasthan (CURAJ); New York Medical
   College; University of Brescia; Rabin Medical Center; Tel Aviv
   University; Chaim Sheba Medical Center; Tel Aviv University; Sackler
   Faculty of Medicine; Cornell University; Weill Cornell Medicine;
   NewYork-Presbyterian Hospital; NewYork-Presbyterian Brooklyn Methodist
   Hospital
RP Peterson, SJ (corresponding author), Weill Cornell Med, Dept Med, New York, NY 10021 USA.; Peterson, SJ (corresponding author), New York Presbyterian Brooklyn Methodist Hosp, Dept Med, Brooklyn, NY 11215 USA.
EM stp9039@med.cornell.edu
RI Waldman, Maayan/G-5369-2015; SINGH, SHAILENDRA PRATAP/R-8524-2018
OI SINGH, SHAILENDRA PRATAP/0000-0003-2996-0374; Rezzani,
   Rita/0000-0002-7515-5846; Favero, Gaia/0000-0001-6895-7106
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NR 56
TC 8
Z9 8
U1 0
U2 5
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2073-4409
J9 CELLS-BASEL
JI Cells
PD OCT
PY 2022
VL 11
IS 19
AR 3060
DI 10.3390/cells11193060
PG 19
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA 5G0CP
UT WOS:000866676400001
PM 36231029
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Coltell, O
   Asensio, EM
   Sorlí, JV
   Barragán, R
   Fernández-Carrión, R
   Portolés, O
   Ortega-Azorín, C
   Martínez-LaCruz, R
   González, JI
   Zanón-Moreno, V
   Gimenez-Alba, I
   Fitó, M
   Ros, E
   Ordovas, JM
   Corella, D
AF Coltell, Oscar
   Asensio, Eva M.
   Sorli, Jose V.
   Barragan, Rocio
   Fernandez-Carrion, Rebeca
   Portoles, Olga
   Ortega-Azorin, Carolina
   Martinez-LaCruz, Raul
   Gonzalez, Jose I.
   Zanon-Moreno, Vicente
   Gimenez-Alba, Ignacio
   Fito, Montserrat
   Ros, Emilio
   Ordovas, Jose M.
   Corella, Dolores
TI Genome-Wide Association Study (GWAS) on Bilirubin Concentrations in
   Subjects with Metabolic Syndrome: Sex-Specific GWAS Analysis and
   Gene-Diet Interactions in a Mediterranean Population
SO NUTRIENTS
LA English
DT Article
DE bilirubin; GWAS; sex-specific; gene-diet interaction; Mediterranean
ID CORONARY-HEART-DISEASE; TOTAL SERUM BILIRUBIN; CIRCULATING BILIRUBIN;
   RISK; LOCUS; METAANALYSIS; UGT1A1; TRAIT
AB Although, for decades, increased serum bilirubin concentrations were considered a threatening sign of underlying liver disease and had been associated with neonatal jaundice, data from recent years show that bilirubin is a powerful antioxidant and suggest that slightly increased serum bilirubin concentrations are protective against oxidative stress-related diseases, such as cardiovascular diseases. Therefore, a better understanding of the gene-diet interactions in determining serum bilirubin concentrations is needed. None of the previous genome-wide association studies (GWAS) on bilirubin concentrations has been stratified by sex. Therefore, considering the increasing interest in incorporating the gender perspective into nutritional genomics, our main aim was to carry out a GWAS on total serum bilirubin concentrations in a Mediterranean population with metabolic syndrome, stratified by sex. Our secondary aim was to explore, as a pilot study, the presence of gene-diet interactions at the GWAS level. We included 430 participants (188 men and 242 women, aged 55-75 years, and with metabolic syndrome) in the PREDIMED Plus-Valencia study. Global and sex-specific GWAS were undertaken to analyze associations and gene-diet interaction on total serum bilirubin. Adherence (low and high) to the Mediterranean diet (MedDiet) was analyzed as the dietary modulator. In the GWAS, we detected more than 55 SNPs associated with serum bilirubin at p < 5 x 10(-8) (GWAS level). The top-ranked were four SNPs (rs4148325 (p = 9.25 x 10(-24)), rs4148324 (p = 9.48 x 10(-24)), rs6742078 (p = 1.29 x 10(-23)), rs887829 (p = 1.39 x 10(-23)), and the rs4148324 (p = 9.48 x 10(-24))) in the UGT1A1 (UDP glucuronosyltransferase family 1 member A1) gene, which replicated previous findings revealing the UGT1A1 as the major locus. In the sex-specific GWAS, the top-ranked SNPs at the GWAS level were similar in men and women (the lead SNP was the rs4148324-UGT1A1 in both men (p = 4.77 x 10(-11)) and women (p = 2.15 x 10(-14)), which shows homogeneous genetic results for the major locus. There was more sex-specific heterogeneity for other minor genes associated at the suggestive level of GWAS significance (p < 1 x 10(-5)). We did not detect any gene-MedDiet interaction at p < 1 x 10(-5) for the major genetic locus, but we detected some gene-MedDiet interactions with other genes at p < 1 x 10(-5), and even at the GWAS level for the IL17B gene (p = 3.14 x 10(-8)). These interaction results, however, should be interpreted with caution due to our small sample size. In conclusion, our study provides new data, with a gender perspective, on genes associated with total serum bilirubin concentrations in men and women, and suggests possible additional modulations by adherence to MedDiet.
C1 [Coltell, Oscar] Univ Jaume 1, Dept Comp Languages & Syst, Castellon de La Plana 12071, Spain.
   [Coltell, Oscar; Asensio, Eva M.; Sorli, Jose V.; Barragan, Rocio; Fernandez-Carrion, Rebeca; Portoles, Olga; Ortega-Azorin, Carolina; Martinez-LaCruz, Raul; Gonzalez, Jose I.; Fito, Montserrat; Ros, Emilio; Corella, Dolores] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr, Madrid 28029, Spain.
   [Asensio, Eva M.; Sorli, Jose V.; Barragan, Rocio; Fernandez-Carrion, Rebeca; Portoles, Olga; Ortega-Azorin, Carolina; Martinez-LaCruz, Raul; Gonzalez, Jose I.; Gimenez-Alba, Ignacio; Corella, Dolores] Univ Valencia, Sch Med, Dept Prevent Med & Publ Hlth, Valencia 46010, Spain.
   [Zanon-Moreno, Vicente] Valencian Int Univ, Area Hlth Sci, Valencia 46002, Spain.
   [Zanon-Moreno, Vicente] Inst Salud Carlos III, Red Temat Invest Cooperat OftaRed, Madrid 28029, Spain.
   [Zanon-Moreno, Vicente] Dr Peset Univ Hosp, Ophthalmol Res Unit Santiago Grisolia, Valencia 46017, Spain.
   [Fito, Montserrat] Inst Hosp Mar Invest Med, Barcelona 08003, Spain.
   [Ros, Emilio] Univ Barcelona, Hosp Clin, IDIBAPS, Lipid Clin,Endocrinol & Nutr Serv, E-08036 Barcelona, Spain.
   [Ordovas, Jose M.] Tufts Univ, Nutr & Genom Lab, JM USDA Human Nutr Res Ctr Aging, Boston, MA 02111 USA.
   [Ordovas, Jose M.] CNIC, Dept Cardiovasc Epidemiol & Populat Genet, Madrid 28029, Spain.
   [Ordovas, Jose M.] IMDEA Alimentac, Madrid 28049, Spain.
C3 Universitat Jaume I; CIBER - Centro de Investigacion Biomedica en Red;
   CIBEROBN; Instituto de Salud Carlos III; University of Valencia;
   Universidad Internacional de Valencia VIU; Instituto de Salud Carlos
   III; University of Barcelona; Hospital Clinic de Barcelona; IDIBAPS;
   Tufts University; United States Department of Agriculture (USDA); Centro
   Nacional de Investigaciones Cardiovasculares (CNIC)
RP Corella, D (corresponding author), Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr, Madrid 28029, Spain.; Corella, D (corresponding author), Univ Valencia, Sch Med, Dept Prevent Med & Publ Hlth, Valencia 46010, Spain.
EM oscar.coltell@uji.es; eva.m.asensio@uv.es; jose.sorli@uv.es;
   rocio.barragan@uv.es; Rebeca.Fernandez@uv.es; Olga.Portoles@uv.es;
   carolina.ortega@uv.es; raulmartinezlacruz@gmail.com;
   Ignacio.Glez-Arraez@uv.es; vczanon@universidadviu.com;
   nachoga16@gmail.com; Mfito@imim.es; EROS@clinic.cat;
   jose.ordovas@tufts.edu; Dolores.corella@uv.es
RI Fernandez-Carrion, Rebeca/AAA-5713-2019; Coltell, Oscar/AAA-9936-2019;
   Alba, Ignacio/ABI-4663-2020; Arraez, Jose/AAA-4830-2019; Sorlí,
   José/L-8758-2014; Asensio, Eva/AAA-5710-2019; Ortega-Azorín,
   Carolina/AAB-2355-2019; Reparaz, Olga/AAB-3243-2019; Zanon-Moreno,
   Vicente/B-8348-2009; Coltell, Oscar/L-8549-2014; Corella,
   Dolores/L-9888-2014; Fito Colomer, Montse/C-1822-2012
OI Zanon-Moreno, Vicente/0000-0003-1179-1592; Coltell,
   Oscar/0000-0002-4518-8495; Corella, Dolores/0000-0002-2366-4104; Fito
   Colomer, Montse/0000-0002-1817-483X; Barragan-Arnal,
   Rocio/0000-0001-8072-3791; Gimenez Alba, Ignacio
   Manuel/0000-0002-6380-8467; Sorli, Jose V/0000-0002-0130-2006
FU Spanish Ministry of Health (Instituto de Salud Carlos III); Ministerio
   de Economia y Competitividad-Fondo Europeo de Desarrollo Regional
   (FEDER) [CIBER 06/03, PRX17/00500, PI16/00366, PI06/1326,
   SAF2016-80532-R]; University Jaume I [P1-1B2013-54, COGRUP/2016/06];
   Fundacio La Marato de TV3 [538/U/2016]; Real Colegio Complutense at
   Harvard University; Fundacion MAPFRE (grant Ignacio Larramendi 2014);
   Rei Jaume I Award for Medical Research 2018; Generalitat Valenciana
   [PROMETEO2017/017, AEST/2018/044]; US Department of Agriculture,
   Agriculture Research Service [8050-51000-098-00D]
FX This study was partially funded by the Spanish Ministry of Health
   (Instituto de Salud Carlos III) and the Ministerio de Economia y
   Competitividad-Fondo Europeo de Desarrollo Regional (FEDER) (grants
   CIBER 06/03, PRX17/00500, PI16/00366, PI06/1326, and SAF2016-80532-R),
   the University Jaume I (grants P1-1B2013-54 and COGRUP/2016/06), the
   Fundacio La Marato de TV3 (grant 538/U/2016), the Real Colegio
   Complutense at Harvard University, the Fundacion MAPFRE (grant Ignacio
   Larramendi 2014), the Rei Jaume I Award for Medical Research 2018, the
   Generalitat Valenciana (grants PROMETEO2017/017, and AEST/2018/044), and
   the US Department of Agriculture, Agriculture Research Service (grant
   8050-51000-098-00D).S
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NR 81
TC 23
Z9 25
U1 1
U2 21
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JAN
PY 2019
VL 11
IS 1
AR 90
DI 10.3390/nu11010090
PG 21
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA HJ8VI
UT WOS:000457477800042
PM 30621171
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Sekgala, MD
   Opperman, M
   Mpahleni, B
   Mchiza, ZJR
AF Sekgala, Machoene Derrick
   Opperman, Maretha
   Mpahleni, Buhle
   Mchiza, Zandile June-Rose
TI Sociodemographic and lifestyle factors and the risk of metabolic
   syndrome in taxi drivers: A focus on street food
SO FRONTIERS IN NUTRITION
LA English
DT Article
DE street food; metabolic syndrome; male taxi drivers; physical activity;
   socio-economic status; South Africa; waist circumference
ID SWEETENED BEVERAGE CONSUMPTION; CARDIOVASCULAR-DISEASE;
   PHYSICAL-ACTIVITY; BLOOD-PRESSURE; ASSOCIATION; HEALTH; HYPERTENSION;
   PATTERNS; FRUIT; RED
AB BackgroundIn South Africa, similar to other populous countries, the taxi industry is an important form of transportation that contributes to the country's development. As a result, minibus taxi driving is an occupation characterized by strenuous activities such as long hours of driving, limited rest, and challenges related to securing passengers, among several others. Consequently, to combat stress, some commercial drivers resort to smoking, overeating unhealthy food sold at transportation interchange areas (i.e., taxi ranks), and participating in sedentary behaviors. Most of these activities are risk factors for metabolic syndrome (MetS). AimTherefore, this study aimed to investigate the sociodemographic and lifestyle factors that predispose South African taxi drivers who work in the Cape Town Metropole area to the risk of developing MetS. MethodsThis cross-sectional study used a convenient sampling method that included 185 male minibus taxi drivers aged 20 years or above. The participants were interviewed using a validated questionnaire to gather information regarding their sociodemographic characteristics and lifestyle practices. They also underwent physical and metabolic assessments, and the International Diabetes Federation (IDF) criteria were used to diagnose people with MetS. ResultsOverall, the mean age and driving experience of the taxi drivers were 40.0 years (SD: 10.7) and 9.1 years (SD: 7.4), respectively, with those with MetS being significantly older and having more driving experience than those without. Older participants were 3 and 2.9 times more likely to be diagnosed with MetS than the younger participants. Most taxi drivers (70%) met the IDF diagnostic criteria for MetS. Smokers, those who spent more than 100 ZAR (USD 5.9) and those who spent less than 1.4 MET-minutes per week on physical activity were 1.96, 2.0, and 13.6 times more likely to suffer from MetS that those who were nonsmokers, those who spent less than 100 ZAR and those who spent <1.4 MET-minutes per week on physical activity. Consumption of alcohol and sugar-sweetened beverages (SSBs), as well as takeaway and fried foods, snacks, and sold by the SF vendors, increased the likelihood of developing MetS, abnormal HDL-C, TG, and hypertension, while avoiding takeaway and fried foods decreased this likelihood. Taxi drivers who also avoided consuming fresh fruits had abnormal HDL-C. ConclusionThese findings have significant public health implications, highlighting the need for South African policymakers to adopt a system-level approach to promote lifestyle changes among taxi drivers within the taxi industry. This can help reduce the health risks faced by these drivers and improve their overall health profile.
C1 [Sekgala, Machoene Derrick; Mchiza, Zandile June-Rose] Univ Western Cape, Sch Publ Hlth, Bellville, South Africa.
   [Sekgala, Machoene Derrick] Human Sci Res Council, Human & Social Capabil, Cape Town, South Africa.
   [Opperman, Maretha; Mpahleni, Buhle] Cape Peninsula Univ Technol, Dept Biotechnol & Consumer Sci, Funct Food Res Unit, Cape Town, South Africa.
   [Mchiza, Zandile June-Rose] South African Med Res Council, Noncommunicable Dis Res Unit, Cape Town, South Africa.
C3 University of the Western Cape; Human Sciences Research Council-South
   Africa; Cape Peninsula University of Technology; South African Medical
   Research Council
RP Sekgala, MD (corresponding author), Univ Western Cape, Sch Publ Hlth, Bellville, South Africa.; Sekgala, MD (corresponding author), Human Sci Res Council, Human & Social Capabil, Cape Town, South Africa.
EM dsekgala@hsrc.ac.za
RI Sekgala, Machoene Derrick/MAI-1673-2025; Opperman, Maretha/AAF-9895-2020
OI Opperman, Maretha/0000-0001-7649-0980; Sekgala, Dr Machoene
   Derrick/0000-0002-0311-8480; Mchiza, Zandile
   June-Rose/0000-0003-2515-9184
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NR 84
TC 2
Z9 2
U1 0
U2 1
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD FEB 23
PY 2023
VL 10
AR 1112975
DI 10.3389/fnut.2023.1112975
PG 15
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 9R4KS
UT WOS:000945624600001
PM 36908907
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Diehl, AM
AF Diehl, AM
TI Lessons from animal models of NASH
SO HEPATOLOGY RESEARCH
LA English
DT Article; Proceedings Paper
CT 3rd JSH Single Topic Conference on Nonalcoholic Steatohepatitis in
   Asia-Oceania
CY 2004
CL Kochi, JAPAN
SP Japan Soc Hepatol, Ajinomoto Pharma Co Ltd, F Hoffmann-La Roch Ltd, GlaxoSmithKline K K, Mitsubishi Pharma Co
DE animal models; tumor necrosis factor alpha; insulin resistance
ID NONALCOHOLIC FATTY LIVER; INDUCED INSULIN-RESISTANCE; TNF-ALPHA;
   UNCOUPLING PROTEIN-2; GENE-EXPRESSION; OBESE MICE; LEPTIN; DISEASE;
   NECROSIS; STEATOHEPATITIS
AB Studies of animals with obesity-related liver disease have taught us much about the mechanisms that mediate this pathology. Our work with genetically obese, insulin-resistant ob/ob mice demonstrates that hepatocytes become steatotic and die at increased rates. Thus, ob/ob mice develop non-alcoholic steatohepatitis (NASH) spontaneously. NASH is intimately related to the insulin resistance (i.e., metabolic) syndrome, a constellation of disorders that result from abnormal production of hormones and cytokines that regulate inflammatory responses. Like humans with the metabolic syndrome, ob/ob mice exhibit increased tumor necrosis factor (TNF) but relatively low levels of adiponectin. Because TNF and adiponectin typically antagonize each other, the combination of increased TNF and decreased adiponectin promotes a state of high TNF activity. Consequently, hepatocytes generate excessive reactive oxygen species (ROS), have altered viability, accumulate lipid and are resistant to insulin. Treatments that inhibit TNF activity or that increase adiponectin improve NASH in ob/ob mice, other mice and humans with NASH. Hence, there is no doubt that cytokine and hormonal imbalances play a key role in the pathogenesis of NASH. However, the fundamental cellular events involved are still poorly understood. Even within very small areas of livers with NASH, most hepatocytes are merely steatotic, while others are ballooned (pre-necrotic), and still others have Succumbed to apoptosis. This observation suggests cell-to-cell variability in the response to chronic inflammatory stress. In NASH, most steatotic hepatocytes survive by inducing adaptive, cytoprotective factors. However, such cells respond to super-imposed toxic and mitogenic stimuli differently than (3)naive(2) (un-adapted) hepatocytes. Fatty hepatocytes tend to be more vulnerable to ATP depletion and less proliferative, perpetuating chronic liver injury while encouraging the expansion of liver progenitor populations that may become neoplastic. Finally, like other causes of chronic injury, NASH increases the risk for cirrhosis. Studies of ob/ob mice demonstrate that progression to cirrhosis is potentiated by leptin. Leptin probably acts at multiple levels to promote hepatic fibrosis, including direct activation of stellate cells via leptin receptors, regulation of pro- and anti-fibrogenic cytokine production by innate immune cells, and modulation of other neuronal factors that regulate stellate cell activation. The latter two mechanisms seem to dominate because stellate cell activation, fibrogenic cytokine production, collagen gene expression and fibrosis can all be induced by manipulating cytokines and neuronal factors in ob/ob mice (that are genetically deficient in leptin). Thus, studies in mice have uncovered several basic mechanisms that explain the dysfunction that occurs in different types of liver cells during the metabolic syndrome. This has important therapeutic implications for human NASH. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
C1 Duke Univ, Dept Med, Durham, NC 27710 USA.
C3 Duke University
RP Duke Univ, Dept Med, Durham, NC 27710 USA.
EM annamae.diehl@duke.edu
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NR 49
TC 126
Z9 139
U1 0
U2 10
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1386-6346
EI 1872-034X
J9 HEPATOL RES
JI Hepatol. Res.
PD OCT
PY 2005
VL 33
IS 2
BP 138
EP 144
DI 10.1016/j.hepres.2005.09.022
PG 7
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Gastroenterology & Hepatology
GA 994PM
UT WOS:000234043700018
PM 16198624
DA 2025-06-11
ER

PT J
AU Abdo, N
   Almasaid, S
   Alhemedi, AJ
   Alghzawi, AA
   Abu Ata, A
   Albojuq, I
AF Abdo, Nour
   Almasaid, Sharifeh
   Alhemedi, Ahlam J.
   Alghzawi, Ahmad Abdalmajeed
   Abu Ata, Albaraa
   Albojuq, Izzaldin
TI A nationwide comparative analysis of the prevalance and determinants of
   non-communicable diseases risk factors between Jordanian and displaced
   Syrian populations
SO BMC PUBLIC HEALTH
LA English
DT Article
DE Noncommunicable diseases; Metabolic syndrome; Hypertension;
   Hyperlipidemia; Diabetes; Jordan; Syria; Refugees; Displacement
ID HYPERTENSION; GUIDELINES
AB Background Focusing on noncommunicable diseases in displaced Syrian populations and comparing it Jordanians can improve health outcomes, reduce suffering, and better integrate displaced individuals into broader public health strategies. Methods A secondary analysis was conducted to STEPs 2019 Survey done in Jordan, the total sample size was 5713 participants, where a multistage stratified clustered sampling was used for both Jordanian and Syrian aged between 18 and 69 years. The Chi-square test was used to compare character variables while T-test was used for continuous variables. A multivariate stepwise logistic regression model was used to identify the risk factors for hypertension (HTN), diabetes (DM), and hyperlipidemia (HLD). Significance was set to 0.05 and was adjusted for multiple comparisons. Results Jordanians exhibit high rates of smoking (35.4%), and high salt intake (30.2%), while Syrians have lower vegetable intake (8%), were more involved in vigorous work-related activity (18.7%), and using active transportation (75.2%). HTN (50.2%), DM (12.3%) and HLD (84.5%) prevalence was higher in Jordanians. However, the HTN prevalence in displaced Syrians (46.6%) in this analysis was much higher than most recent reported numbers in literature prior to the war and DM (7.2%) was lower. HTN, DM, HLD and metabolic syndrome exhibited strong associations with demographic and lifestyle factors, where older age groups were more predisposed (p < 0.00). Both college and school education had lower odds from metabolic syndrome, (odds ratio [OR] = 0.29, 95% CI = 0.17-0.48), and (OR = 0.53, 95% CI = 0.37-0.76) respectively in both populations. Lower education was also associated with higher odds of HTN, DM, and dyslipidemia in Jordanian population only. DM had lower odds in men (vs. women) only in the Syrian population (OR = 0.68, 95% CI = 0.51-0.92). Rural residence had higher odds of HTN in both populations (OR = 1.24, 95% CI = 1.02-1.49). The use of active transportation has lower odds of MS and DM in both populations. Being active in leisure-or-work was positively associated with lower odds of MS in both populations. Jordanians showed higher odds of MS (OR = 1.48, 95%CI 1.15-1.89) and HDL compared to Syrians (OR = 1.29, 95% CI = 1.09-1.52). Conclusion The disease burden in Syrian refugees in Jordan is related to barriers to healthcare access and economic stability, lower awareness when to seek medical attention, and increasing stress levels, which all leads to disruption in the longitudinal care needed for NCD management. This necessitates tailored interventions to ensure accessibility and responsiveness to healthcare needs as the blame is not on displacement by itself given its effect cannot be proven.
C1 [Abdo, Nour; Almasaid, Sharifeh; Alhemedi, Ahlam J.; Alghzawi, Ahmad Abdalmajeed] Jordan Univ Sci & Technol, Fac Med, Dept Publ Hlth, Irbid, Jordan.
   [Almasaid, Sharifeh] SUNY Upstate Med Univ Hosp, Dept Internal Med, Syracuse, NY USA.
   [Abu Ata, Albaraa] Minist Hlth, Amman, Jordan.
   [Albojuq, Izzaldin] Jordan Univ Sci & Technol, Fac Med, Dept Emergency Med, Irbid, Jordan.
C3 Jordan University of Science & Technology; State University of New York
   (SUNY) System; State University of New York (SUNY) Upstate Medical
   Center; Jordan University of Science & Technology
RP Abdo, N (corresponding author), Jordan Univ Sci & Technol, Fac Med, Dept Publ Hlth, Irbid, Jordan.
EM nmabdo@just.edu.jo
RI Alhemedi, Ahlam Jamal/JLL-6657-2023
FU Deanship of Research at Jordan University of Science and Technology
FX The authors would like to thank Deanship of Research at Jordan
   University of Science and Technology.
CR Abboud SamerN., 2015, Syria
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NR 40
TC 0
Z9 0
U1 1
U2 1
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2458
J9 BMC PUBLIC HEALTH
JI BMC Public Health
PD MAY 20
PY 2025
VL 25
IS 1
AR 1862
DI 10.1186/s12889-025-22539-0
PG 13
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA 2VE5C
UT WOS:001492085600011
PM 40394471
DA 2025-06-11
ER

PT J
AU Jia, QL
   Shi, SQ
   Yuan, GZ
   Shi, JJ
   Shi, S
   Wei, Y
   Hu, YH
AF Jia, Qiulei
   Shi, Shuqing
   Yuan, Guozhen
   Shi, Jingjing
   Shi, Shuai
   Wei, Yi
   Hu, Yuanhui
TI The effect of nicorandil in patients with cardiac syndrome X A
   meta-analysis of randomized controlled trials
SO MEDICINE
LA English
DT Review
DE cardiac syndrome X; meta-analysis; nicorandil; randomized controlled
   trials; systematic review
ID CORONARY MICROVASCULAR DYSFUNCTION; ANGINA-PECTORIS; ENDOTHELIAL
   DYSFUNCTION; ARTERY-DISEASE; NITRIC-OXIDE; CHEST-PAIN; FOLLOW-UP;
   ISCHEMIA; ASSOCIATION; ANGIOGRAPHY
AB Background: The prevalence of cardiac syndrome X (CSX) is considerable. Some patients show recurrent angina attacks and have a poor prognosis. However, the knowledge of CSX pathophysiological mechanism is still limited, and the treatment fails to achieve a satisfactory suppression of symptoms. Nicorandil has a beneficial effect on improving coronary microvascular dysfunction (CMD). This study aims to evaluate the clinical effects and safety of nicorandil on CSX patients. Methods: The Cochrane Library, Pubmed, EMBASE, ClinicalTrials.gov and 4 Chinese databases were searched to identify relevant studies. The Cochrane "Risk of bias" tool was used to assess the methodological quality of eligible studies. Meta-analysis was performed by RevMan 5.3 software. The Eggers test and meta-regression were performed by software Stata 14.0. Quality of evidence was assessed using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach. Results: Twenty four randomized controlled trials (RCTs) involving 2323 patients were included. Most of the included studies were classified as having an unclear risk of bias because of poor reported methodology. The main outcomes are angina symptoms improvement, resting electrocardiogram (ECG) improvement, treadmill test result, and endothelial function. Meta-analysis showed that nicorandil had some benefit on improving angina symptoms (RR 1.24, 95% CI 1.19 to 1.29,I-2 = 20%,P < .00001), resting ECG (RR = 1.24, 95% IC: 1.15 to 1.33,I-2 = 0%,P < .00001), and prolonged the time to 1 mm ST-segment depression in treadmill test result (WMD = 38.41, 95% IC: 18.46 to 58.36,I-2 = 0%,P = .0002). Besides nicorandil could reduce the level of endothelin-1 (ET-1) (SMD = -2.22, 95% IC: -2.61 to -1.83,I-2 = 77%,P < .00001) and increase the level of nitric oxide (NO) (WMD = 27.45, 95% IC: 125.65 to 29.24,I-2 = 81%,P < .00001). No serious adverse drug event was reported. The Eggers test showed that significant statistical publication bias was detected (Eggers testP = .000). The quality of evidence ranged from very low to low. Conclusions: Nicorandil shows the potential of improving angina symptoms, ECG, and endothelial dysfunction in patients with CSX. However, there is insufficient evidence for the clinical benefits of nicorandil due to the very low-quality evidence.
C1 [Jia, Qiulei; Shi, Shuqing; Yuan, Guozhen; Shi, Jingjing; Shi, Shuai; Wei, Yi; Hu, Yuanhui] China Acad Chinese Med Sci, Guanganmen Hosp, Dept Cardiovasc, Beijing, Peoples R China.
   [Jia, Qiulei; Shi, Shuqing] Beijing Univ Chinese Med, Grad Sch, Beijing, Peoples R China.
C3 Guang'anmen Hospital, CACMS; China Academy of Chinese Medical Sciences;
   Beijing University of Chinese Medicine
RP Hu, YH (corresponding author), China Acad Chinese Med Sci, Guanganmen Hosp, Dept Cardiovasc, Beijing, Peoples R China.
EM huiyuhui550@sohu.com
RI shi, shuqing/GSO-0662-2022
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NR 70
TC 11
Z9 11
U1 0
U2 7
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD SEP 11
PY 2020
VL 99
IS 37
DI 10.1097/MD.0000000000022167
PG 16
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA OC5EX
UT WOS:000579180600075
PM 32925783
OA Green Published
DA 2025-06-11
ER

PT J
AU Matsumoto, S
   Shimabukuro, M
   Fukuda, D
   Soeki, T
   Yamakawa, K
   Masuzaki, H
   Sata, M
AF Matsumoto, Sachiko
   Shimabukuro, Michio
   Fukuda, Daiju
   Soeki, Takeshi
   Yamakawa, Ken
   Masuzaki, Hiroaki
   Sata, Masataka
TI Azilsartan, an angiotensin II type 1 receptor blocker, restores
   endothelial function by reducing vascular inflammation and by increasing
   the phosphorylation ratio Ser<SUP>1177</SUP>/Thr<SUP>497</SUP> of
   endothelial nitric oxide synthase in diabetic mice
SO CARDIOVASCULAR DIABETOLOGY
LA English
DT Article
ID GLOBAL CARDIOMETABOLIC RISK; OXIDATIVE STRESS; CONVERTING ENZYME; NADPH
   OXIDASES; URIC-ACID; INSULIN; DYSFUNCTION; EXPRESSION; MELLITUS; GLUCOSE
AB Background: Azilsartan, an angiotensin II type 1 (AT1) receptor blocker (ARB), has a higher affinity for and slower dissociation from AT1 receptors and shows stronger inverse agonism compared to other ARBs. Possible benefits of azilsartan in diabetic vascular dysfunction have not been established.
   Methods: We measured vascular reactivity of aortic rings in male KKAy diabetic mice treated with vehicle, 0.005% azilsartan, or 0.005% candesartan cilexetil for 3 weeks. Expression of markers of inflammation and oxidative stress was measured using semiquantitative RT-PCR in the vascular wall, perivascular fat, and skeletal muscle. Phosphorylation of endothelial nitric oxide synthase (eNOS) at Ser(1177) and Thr(495) was measured using Western blotting, and the ratio of phosphorylation at Ser(1177) to phosphorylation at Thr(495) was used as a putative indicator of vascular eNOS activity.
   Results: (1) Vascular endothelium-dependent relaxation with acetylcholine in KKAy mice was improved by azilsartan treatment compared to candesartan cilexetil; (2) the ratio of Ser(1177)/Thr(495) phosphorylation of eNOS was impaired in KKAy and was effectively restored by azilsartan; (3) anomalies in the expression levels of monocyte chemotactic protein 1 (MCP1), F4/80, NAD(P) H oxidase (Nox) 2, and Nox4 of the aortic wall and in the expression of TNF alpha in the perivascular fat were strongly attenuated by azilsartan compared to candesartan cilexetil.
   Conclusions: These results provide evidence that azilsartan prevents endothelial dysfunction in diabetic mice, more potently than does candesartan cilexetil. Azilsartan's higher affinity for and slower dissociation from AT1 receptors may underlie its efficacy in diabetic vascular dysfunction via a dual effect on uncoupled eNOS and on Nox.
C1 [Matsumoto, Sachiko; Soeki, Takeshi; Sata, Masataka] Univ Tokushima, Grad Sch Hlth Biosci, Dept Cardiovasc Med, Tokushima 7708503, Japan.
   [Shimabukuro, Michio; Fukuda, Daiju] Univ Tokushima, Grad Sch Hlth Biosci, Dept Cardiodiabet Med, Tokushima 7708503, Japan.
   [Yamakawa, Ken; Masuzaki, Hiroaki] Univ Ryukyus, Grad Sch Med, Dept Internal Med 2, Div Endocrinol Diabet & Metab, Okinawa, Japan.
C3 Tokushima University; Tokushima University; University of the Ryukyus
RP Shimabukuro, M (corresponding author), Univ Tokushima, Grad Sch Hlth Biosci, Dept Cardiodiabet Med, 3-18-15 Kuramoto, Tokushima 7708503, Japan.
EM mshimabukuro-ur@umin.ac.jp
RI Fukuda, Daiju/AAO-6752-2021; Sata, Masataka/IST-9041-2023
OI Shimabukuro, Michio/0000-0001-7835-7665
FU JSPS KAKENHI [60271144, 25460369, 24659392, 22390159, 25670390,
   25293184]; MEXT KAKENHI [21117007]; Grants-in-Aid for Scientific
   Research [25293184, 23591314, 24659392, 21117007, 24591063, 22390159,
   25460369] Funding Source: KAKEN
FX This work was supported by JSPS KAKENHI Grant Number 60271144 (MiS),
   JSPS KAKENHI Grant Number 25460369 (DF), and MEXT KAKENHI Grant Number
   21117007, JSPS KAKENHI Grant Numbers 24659392, 22390159, 25670390, and
   25293184 (MaS).
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NR 55
TC 41
Z9 45
U1 0
U2 5
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1475-2840
J9 CARDIOVASC DIABETOL
JI Cardiovasc. Diabetol.
PD JAN 31
PY 2014
VL 13
AR 30
DI 10.1186/1475-2840-13-30
PG 10
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism
GA AD0YG
UT WOS:000332959900001
PM 24485356
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Appiakannan, HS
   Kestyus, DR
   Weber, ET
AF Appiakannan, Harish S.
   Kestyus, Daniel R.
   Weber, E. Todd
TI Effects of high fat diet and chronic circadian challenge on
   glucocorticoid regulation in C57BL/6J mice
SO PHYSIOLOGY & BEHAVIOR
LA English
DT Article
ID INSULIN-RESISTANCE; METABOLIC SYNDROME; CORTICOSTERONE; MOUSE;
   DISRUPTION; OBESITY; CONSEQUENCES; RHYTHMS; BRAIN; MODEL
AB Both high-fat diet and chronic circadian disruption have been associated with increased incidence of obesity and type 2 diabetes in humans. Chronically elevated glucocorticoids, which have considerable impacts on physiological processes such as intermediary metabolism, inflammation, and fat metabolism, have also been implicated in insulin resistance associated with obesity and diabetes. In this study, the effects of high-fat diet (HFD) or chronic circadian challenge in C57BL/6J mice on basal and stress-induced corticosterone (CORT) and blood glucose levels were assessed. Baseline and stress-induced levels of CORT, insulin and glucose were measured before and after acute restraint stress at 4 different time points across the light-dark cycle (LD) in male C57BL/6J mice maintained for 8 weeks on HFD or regular chow. After 8 weeks on diet, baseline CORT levels in HFD mice were of similar magnitude but more variable than in mice on low-fat diet, rendering their daily fluctuations arrhythmic according to statistical analysis. Baseline glucose measures were unchanged despite significant 3-fold increases in baseline insulin levels in HFD mice at all time points sampled. Restraint stress yielded considerable decreases in insulin levels and increases in CORT and glucose levels that were significantly exaggerated in the early active period in mice on HFD. These results indicate a circadian influence on stress responses after prolonged consumption of high fat diet. In a separate experiment, C57BL/6J mice were subjected to 6 weeks of an alternating light-dark (LD) cycle comprised of 6 h advances and delays of phase every 5 days to keep the circadian system from establishing consistent circadian entrainment, with a control group of mice under a regular 12:12 LD cycle. While body weights were not significantly affected by chronic circadian challenge, the basal CORT rhythm in alternating-LD mice was significantly dampened. Stress-induced CORT in alternating ID were no different from regular ID group with the exception of ZT 18, at which time the stress response was moderately suppressed compared to controls. These results support that high-fat diet may be contributing to health disorders such as obesity and diabetes in a manner different from any effects of chronic circadian disruption.
C1 [Appiakannan, Harish S.; Kestyus, Daniel R.; Weber, E. Todd] Rider Univ, Dept Biol Behav Neurosci & Hlth Sci, 2083 Lawrenceville Rd, Lawrenceville, NJ 08648 USA.
C3 Rider University
RP Weber, ET (corresponding author), Rider Univ, Dept Biol Behav Neurosci & Hlth Sci, 2083 Lawrenceville Rd, Lawrenceville, NJ 08648 USA.
EM tweber@rider.edu
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NR 31
TC 16
Z9 18
U1 0
U2 15
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0031-9384
J9 PHYSIOL BEHAV
JI Physiol. Behav.
PD MAY 15
PY 2019
VL 204
BP 100
EP 105
DI 10.1016/j.physbeh.2019.01.014
PG 6
WC Psychology, Biological; Behavioral Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Behavioral Sciences
GA HX6JE
UT WOS:000467509100013
PM 30769107
DA 2025-06-11
ER

PT J
AU Battino, M
   Giampieri, F
   Cianciosi, D
   Ansary, J
   Chen, XM
   Zhang, D
   Gil, E
   Forbes-Hernández, T
AF Battino, Maurizio
   Giampieri, Francesca
   Cianciosi, Danila
   Ansary, Johura
   Chen, Xiumin
   Zhang, Di
   Gil, Emilio
   Forbes-Hernandez, Tamara
TI The roles of strawberry and honey phytochemicals on human health: A
   possible clue on the molecular mechanisms involved in the prevention of
   oxidative stress and inflammation
SO PHYTOMEDICINE
LA English
DT Article
DE Honey; Strawberry; Polyphenols; Bioavailability; Oxidative stress;
   Inflammation
ID FREEZE-DRIED STRAWBERRY; PLASMA ANTIOXIDANT STATUS; HUMAN DERMAL
   FIBROBLASTS; GELAM HONEY; DNA-DAMAGE; IRRADIATION DAMAGE;
   URINARY-EXCRETION; ANANASSA EXTRACT; REDOX REGULATION; INDUCED TOXICITY
AB Background: Oxidative stress and inflammation contribute to the etiopathogenesis of several human chronic diseases, such as cancer, diabetes, cardiovascular diseases and metabolic syndrome. Besides classic stimuli, such as reactive oxidant species, endotoxins (i.e., bacteria lipopolysaccharide), cytokines or carcinogens, oxidative stress and inflammation can be triggered by a poor diet and an excess of body fat and energy intake. Strawberry and honey are common rich sources of nutrients and bioactive compounds, widely studied for their roles exerted in health maintenance and disease prevention.
   Purpose: This review aims to summarize and update the effects of strawberry and honey against oxidative stress and inflammation, with emphasis on metabolism and on the main molecular mechanisms involved in these effects.
   Methods: A wide range of literature, published in the last 10 years, elucidating the effects of strawberry and honey in preventing oxidative stress and inflammation both in vitro (whole matrix and digested fractions) and in vivo was collected from online electronic databases (PubMed, Scopus and Web of Science) and reviewed.
   Results: Strawberry and honey polyphenols may potentially prevent the chronic diseases related to oxidative stress and inflammation. Several in vitro and in vivo studies reported the effects of these foods in suppressing the oxidative stress, by decreasing ROS production and oxidative biomarkers, restoring the antioxidant enzyme activities, ameliorating the mitochondrial antioxidant status and functionality, among others, and the inflammatory process, by modulating the mediators of acute and chronic inflammation essential for the onset of several human diseases. These beneficial properties are mediated in part through their ability to target multiple signaling pathways, such as p38 MAPK, AMPK, PI3K/Akt, NF-kappa B and Nrf2.
   Conclusions: Available scientific literature show that strawberry and honey may be effective in preventing oxidative stress and inflammation. The deep evaluation of the factors that affect their metabolism as well as the assessment of the main molecular mechanisms involved are of extreme importance for the possible therapeutic and preventive benefit against the most common human diseases. However, published literature is still scarce so that deeper studies should be performed in order to evaluate the bioavailability of these food matrices and their effects after digestion.
C1 [Battino, Maurizio; Giampieri, Francesca; Gil, Emilio; Forbes-Hernandez, Tamara] Univ Vigo, Dept Analyt & Food Chem, CITACA, Nutr & Food Sci Grp,CACTI, Vigo Campus, Vigo, Spain.
   [Battino, Maurizio; Chen, Xiumin; Zhang, Di] Jiangsu Univ, Int Res Ctr Food Nutr & Safety, Zhenjiang 212013, Jiangsu, Peoples R China.
   [Battino, Maurizio; Giampieri, Francesca; Cianciosi, Danila; Ansary, Johura] Polytech Univ Marche, Fac Med, Dept Clin Sci, Ancona, Italy.
   [Zhang, Di] Jiangsu Hengshun Grp Co Ltd, Zhenjiang 212000, Jiangsu, Peoples R China.
C3 Universidade de Vigo; Jiangsu University; Marche Polytechnic University
RP Forbes-Hernández, T (corresponding author), Univ Vigo, Dept Analyt & Food Chem, CITACA, Nutr & Food Sci Grp,CACTI, Vigo Campus, Vigo, Spain.; Battino, M (corresponding author), Univ Politecn Marche, Fac Med, Sez Biochim, Dipartimento Sci Clin Specialist Odontostomatol D, Via Ranieri 65, I-60131 Ancona, Italy.
EM m.a.battino@univpm.it; tamara.forbe@gmail.com
RI Cianciosi, Danila/H-7405-2019; Ansary, J/AAL-2565-2021; Chen,
   Xiumin/R-2596-2018; Forbes Hernandez, Tamara/AAB-1872-2021; Battino,
   Maurizio/E-6103-2012; Giampieri, Francesca/I-1911-2015
OI Cianciosi, Danila/0000-0002-8781-3535; Forbes Hernandez,
   Tamara/0000-0001-7021-9276; Battino, Maurizio/0000-0002-7250-1782;
   Ansary, Ph.D, Johura/0000-0003-3301-7215; Giampieri,
   Francesca/0000-0002-8151-9132; Chen, Xiumin/0000-0003-2622-1824
FU post-doctoral fund of Jiangsu Province, China [2019K016]; "Juan de la
   Cierva" postdoctoral contract
FX Tamara Forbes Hernandez is supported by a "Juan de la Cierva"
   postdoctoral contract. DZ thanks for financial support by post-doctoral
   fund of Jiangsu Province, China (no. 2019K016).
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NR 175
TC 74
Z9 77
U1 5
U2 130
PU ELSEVIER GMBH
PI MUNICH
PA HACKERBRUCKE 6, 80335 MUNICH, GERMANY
SN 0944-7113
EI 1618-095X
J9 PHYTOMEDICINE
JI Phytomedicine
PD JUN
PY 2021
VL 86
AR 153170
DI 10.1016/j.phymed.2020.153170
EA MAY 2021
PG 18
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA SE4DZ
UT WOS:000652024800005
PM 31980299
DA 2025-06-11
ER

PT J
AU Lin, CY
   Lee, HL
   Hwang, YT
   Su, TC
AF Lin, Chien-Yu
   Lee, Hui-Ling
   Hwang, Yi-Ting
   Su, Ta-Chen
TI The association between total serum isomers of per- and polyfluoroalkyl
   substances, lipid profiles, and the DNA oxidative/nitrative stress
   biomarkers in middle-aged Taiwanese adults
SO ENVIRONMENTAL RESEARCH
LA English
DT Article
DE 8-Hydroxy-2-deoxyguanosine (8-OHdG); 8-Nitroguanine (8-NO2Gua); Per- and
   polyfluoroalkyl substances (PFAS); Perfluorooctanoic acid (PFOA);
   Perfluorooctane sulfonate (PFOS)
ID PERFLUOROOCTANOIC ACID EXPOSURE; INTIMA-MEDIA THICKNESS;
   CORONARY-HEART-DISEASE; SPRAGUE-DAWLEY RATS; C8 HEALTH PROJECT;
   PERFLUORINATED CHEMICALS; OXIDATIVE STRESS; GLUCOSE-HOMEOSTASIS;
   PERFLUOROALKYL ACIDS; METABOLIC SYNDROME
AB Per- and polyfluoroalkyl substances (PFAS) have been widely used in consumer products. In vitro and animal studies have demonstrated that exposure to perfluorooctanoic acid (PFOA) and/or perfluorooctane sulfonate (PFOS) increases oxidative/nitrative stress. Recent studies have also found that isomers of PFOA/PFOS may have unique biological effects on clinical parameters. However, the correlation between PFOA/PFOS isomers and markers of oxidative/nitrative stress has never been investigated in the general population. In the current study, 597 adult subjects (ages between 22 and 63 years old) were enrolled from a control group of a case-control study entitled "Work-related risk factors and coronary heart disease". We investigated the correlation between the serum isomers of PFOA/PFOS, lipid profiles, and the urine compounds 8-hydroxy-2-deoxyguanosine (8-OHdG) and 8-nitroguanine (8-NO2Gua) in these participants. There were 519 men and 78 women with a mean age of 45.8 years. Linear PFOA levels were positively correlated with serum low density lipoprotein cholesterol (L-DLC), small dense LDL, and triglyceride, and linear PFOS levels were positively correlated with LDL-C and HDL-C in multiple linear regression analyses. After controlling for potential confounders, the mean levels of 8-OHdG and 8-NO2Gua significantly increased across the quartiles of linear PFOS in multiple linear regression analyses. When both the 8-OHdG and 8-NO2Gua levels were above the 50th percentile, the odds ratio (OR) of higher levels of LDL-C ( > 75th percentile) with one unit increase in In linear PFOS level was the highest (OR 3.15 (95% CI = 1.45-6.64), P = 0.003) in logistic regression models. In conclusion, serum linear PFOA/PFOS were correlated with lipid profiles, and linear PFOS was associated with urine oxidative/nitrative stress biomarkers. The positive correlation between linear PFOS and LDL-C was more marked when concentrations of urine oxidative/nitrative stress biomarkers were elevated. Further studies are needed to elucidate the causal relationships among PFAS isomers, lipid profiles, and oxidative/nitrative stress.
C1 [Lin, Chien-Yu] En Chu Kong Hosp, Dept Internal Med, New Taipei 237, Taiwan.
   [Lin, Chien-Yu] Fu Jen Catholic Univ, Sch Med, New Taipei 242, Taiwan.
   [Lin, Chien-Yu] Yuanpei Univ Med Technol, Dept Environm Engn & Hlth, Hsinchu 300, Taiwan.
   [Lee, Hui-Ling] Fu Jen Catholic Univ, Dept Chem, New Taipei 242, Taiwan.
   [Hwang, Yi-Ting] Natl Taipei Univ, Dept Stat, New Taipei 237, Taiwan.
   [Su, Ta-Chen] Natl Taiwan Univ Hosp, Dept Environm & Occupat Med, Taipei 100, Taiwan.
   [Su, Ta-Chen] Natl Taiwan Univ Hosp, Dept Internal Med, Taipei 100, Taiwan.
   [Su, Ta-Chen] Natl Taiwan Univ Hosp, Cardiovasc Ctr, Taipei 100, Taiwan.
   [Su, Ta-Chen] Natl Taiwan Univ, Coll Publ Hlth, Inst Environm & Occupat Hlth Sci, Taipei 100, Taiwan.
C3 Fu Jen Catholic University; Fu Jen Catholic University; National Taipei
   University; National Taiwan University; National Taiwan University
   Hospital; National Taiwan University; National Taiwan University
   Hospital; National Taiwan University; National Taiwan University
   Hospital; National Taiwan University
RP Su, TC (corresponding author), Natl Taiwan Univ Hosp, Dept Internal Med, Taipei 10002, Taiwan.; Su, TC (corresponding author), Natl Taiwan Univ Hosp, Cardiovasc Ctr, Taipei 10002, Taiwan.
EM tachensu@gmail.com
RI , shen/GXH-0183-2022
OI SU, TA-CHEN/0000-0001-7523-7166
FU Ministry of Science and Technology of Taiwan [MOST 103-2314-B-385 -002
   -, MOST 106-2314-B-385 -001 -, MOST 107-2314-B-385 -003 -]; National
   Health Institute [NHRI EX979721PC, NHRI EX106-10629PI]
FX We thanks to the all the people helped to establish the cohort. This
   study was supported by grants from the Ministry of Science and
   Technology of Taiwan (MOST 103-2314-B-385 -002 -, MOST 106-2314-B-385
   -001 -and MOST 107-2314-B-385 -003 -). We also would like to thank to
   the grant support from National Health Institute (NHRI EX979721PC and
   NHRI EX106-10629PI).
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NR 57
TC 42
Z9 45
U1 4
U2 79
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0013-9351
EI 1096-0953
J9 ENVIRON RES
JI Environ. Res.
PD MAR
PY 2020
VL 182
AR 109064
DI 10.1016/j.envres.2019.109064
PG 6
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA KP2TP
UT WOS:000516094400057
PM 31884197
DA 2025-06-11
ER

PT J
AU Tan, MY
   Zhang, YJ
   Zhu, SX
   Wu, S
   Zhang, P
   Gao, M
AF Tan, Mo-Yao
   Zhang, Yu-Jun
   Zhu, Si-Xuan
   Wu, Shan
   Zhang, Ping
   Gao, Ming
TI The prognostic significance of stress hyperglycemia ratio in evaluating
   all-cause and cardiovascular mortality risk among individuals across
   stages 0-3 of cardiovascular-kidney-metabolic syndrome: evidence from
   two cohort studies
SO CARDIOVASCULAR DIABETOLOGY
LA English
DT Article
DE Cardiovascular-kidney-metabolic syndrome; Stress hyperglycemia ratio;
   All-cause and cardiovascular mortality; NHANES; CHARLES
ID CORONARY-HEART-DISEASE; ASSOCIATION; EVENTS; UPDATE; IMPACT; INDEX; WELL
AB BackgroundThe American Heart Association (AHA) proposed the concept of cardiovascular-kidney-metabolic (CKM) syndrome, underscoring the interconnectedness of cardiovascular, renal, and metabolic diseases. The stress hyperglycemia ratio (SHR) represents an innovative indicator that quantifies blood glucose fluctuations in patients experiencing acute or subacute stress, correlating with detrimental clinical effects. Nevertheless, the prognostic significance of SHR within individuals diagnosed with CKM syndrome in stages 0 to 3, particularly with respect to all-cause or cardiovascular disease (CVD) mortality risks, has not been fully understood yet.MethodsThe current study analyzed data from 9647 participants with CKM syndrome, covering stages 0 to 3, based on the NHANES (National Health and Nutrition Examination Survey) collected from 2007 to 2018. In this study, the primary exposure variable was the SHR, computed as fasting plasma glucose divided by (1.59 * HbA1c - 2.59). The main endpoints of study were all-cause mortality as well as CVD mortality, with death registration data sourced through December 31, 2019. The CHARLS database (China Health and Retirement Longitudinal Study) was utilized as validation to enhance the reliability of the findings.ResultsThis study included 9647 NHANES participants, who were followed for a median duration of 6.80 years. During this period, 630 all-cause mortality cases and 135 CVD-related deaths in total were recorded. After full adjustment for covariates, our results displayed a robust positive association of SHR with all-cause mortality (Hazard ratio [HR] = 1.09, 95% Confidence interval [CI] 1.04-1.13). However, the SHR exhibited no significant relationship with CVD mortality (HR = 1.00, 95% CI 0.91-1.11). The mediation analysis results suggested that the relationship between SHR and all-cause mortality risk is partially mediated by RDW, albumin, and RAR. Specifically, the mediating effects were - 17.0% (95% CI - 46.7%, - 8.7%), - 10.1% (95% CI - 23.9%, - 4.7%), and - 23.3% (95% CI - 49.0%, - 13.0%), respectively. Additionally, analyses of the CHARLS database indicated a significant positive correlation between SHR and all-cause mortality among individuals diagnosed with CKM across stages 0-3 during the follow-up period from 2011 to 2020.ConclusionsAn increased SHR value is positively associated with an elevated likelihood of all-cause mortality within individuals diagnosed with CKM syndrome across stages 0-3, yet it shows no significant association with CVD mortality. SHR is an important tool for predicting long-term adverse outcomes in this population.Research insights summaryCardiovascular-kidney-metabolic (CKM) syndrome emphasizes the interconnectedness of cardiovascular, kidney, and metabolic diseases. The stress hyperglycemia ratio (SHR) is a novel marker reflecting stress-induced glucose fluctuations, but its prognostic value in individuals with CKM syndrome (stages 0-3) remains uncertain. This study explores the association between SHR and all-cause and cardiovascular disease (CVD) mortality in this population. Our findings indicate that SHR is significantly associated with an increased risk of all-cause mortality (HR = 1.09, 95% CI 1.04-1.13), but not with CVD mortality (HR = 1.00, 95% CI: 0.91-1.11). Mediation analysis results suggested that the relationship between SHR and all-cause mortality risk is partially mediated by RDW, albumin, and RAR. Specifically, the mediating effects were - 17.0% (95% CI - 46.7%, - 8.7%), - 10.1% (95% CI - 23.9%, - 4.7%), and - 23.3% (95% CI - 49.0%, - 13.
   0%), respectively. Validation using the CHARLS database supports these findings. These results suggest that SHR could serve as a prognostic biomarker for long-term mortality risk in CKM patients, offering potential clinical utility in risk stratification and management.
C1 [Tan, Mo-Yao; Zhang, Ping; Gao, Ming] Chengdu Integrated TCM & Western Med Hosp, Dept Cardiol, Chengdu, Sichuan, Peoples R China.
   [Zhang, Yu-Jun] Nanchang Univ, HuanKui Acad, Jiangxi Med Coll, Nanchang 330006, Jiangxi, Peoples R China.
   [Zhu, Si-Xuan; Wu, Shan] Chengdu Univ Tradit Chinese Med, Clin Med Sch, Chengdu, Sichuan, Peoples R China.
C3 Nanchang University; Chengdu University of Traditional Chinese Medicine
RP Gao, M (corresponding author), Chengdu Integrated TCM & Western Med Hosp, Dept Cardiol, Chengdu, Sichuan, Peoples R China.
EM 18224409355@163.com
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NR 76
TC 1
Z9 1
U1 11
U2 11
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1475-2840
J9 CARDIOVASC DIABETOL
JI Cardiovasc. Diabetol.
PD MAR 24
PY 2025
VL 24
IS 1
AR 137
DI 10.1186/s12933-025-02689-6
PG 18
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism
GA 0MK7T
UT WOS:001450842000002
PM 40128747
OA gold
DA 2025-06-11
ER

PT J
AU Micol, V
   Larson, H
   Edeas, B
   Ikeda, T
AF Micol, Vicente
   Larson, Helen
   Edeas, Bejit
   Ikeda, Takuya
TI Watermelon extract stimulates antioxidant enzymes and improves glycemic
   and lipid metabolism
SO AGRO FOOD INDUSTRY HI-TECH
LA English
DT Article
ID OXIDATIVE STRESS; SUPEROXIDE-DISMUTASE
AB Obesity is one of the main causes in the development of metabolic syndrome (MS). A close correlation has been found between increase oxidative stress in accumulated fat and the pathogenic mechanism of obesity-associated MS. This may be the source of several metabolic dysfunctions like inflammation, hypertension, and impair glucose intake in muscle and fat which are highly related to obesity. We propose that improving the antioxidant status and reducing the oxidative stress in the body using antioxidant nutritional supplements may be a therapy for obesity in humans. A dietary ingredient (ActiSOD(R)) has been developed which activates human antioxidant enzymes and reduces oxidative stress. The nanoencapsulated ingredient is composed of an extract from watermelon (Citrullus lanatus) naturally enriched in lycopene, i.e, the best singlet oxygen quencher citrulline, an antioxidant amino acid which detoxifies ammonia through the urea cycle, and potassium which improves water balance through its diuretic action. The nanoencapsulation process is focused to improve the delivery of the watermelon extract antioxidants at intracellular level. The biological properties of the dietary supplement have been supported by a randomised, double-blind and placebo-controlled clinical study carried in healthy human volunteers with 5-25 overweight kilos a high post prandial glycemia. Several biological measurements (Insulinemia, glycemia, HOMA (Homeostasy Model Assessment), cholesterol, LDL, HDL, and triglycerides) were measured at d0 and d30 as well as bio-markers of oxidative stress lipids peroxidation, and LDL oxidation. Levels of antioxidant enzymes, superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX) were measured. Blood glycemia tests were done before and after each breakfast The results show that the group having the watermelon extract showed an important increase of antioxidant enzymes (+18 percent for SOD, 20 percent CAT and 17 percent for GPX). Oxidative stress biomarkers demonstrated a clear improvement, with a concomitant reduction in glycemia (-13.90 percent), insulinemia (8.26 percent), and HOMA index (-12.24 percent) occurring at d30. Finally, a remarkable decrease of BMI (body mass index) of 2.02 points and a weight loss of 3.06 kg were observed at the end of the trial, All these results suggest that antioxidants from watermelon may represent a new alternative to reduce the obesity induced by oxidative stress.
C1 Univ Miguel Hernandez, Inst Mol & Cellular Biol, E-03202 Elche, Alicante, Spain.
   Latria, Ninapharm R&D Ctr, F-74000 Annecy, France.
C3 Universidad Miguel Hernandez de Elche
RP Micol, V (corresponding author), Univ Miguel Hernandez, Inst Mol & Cellular Biol, Avda Ferrocarril S-N, E-03202 Elche, Alicante, Spain.
RI Micol, Vicente/K-6841-2014
OI Micol, Vicente/0000-0001-8089-0696
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NR 16
TC 4
Z9 4
U1 0
U2 23
PU TEKNOSCIENZE PUBL
PI MILANO
PA VIALE BRIANZA 22, 20127 MILANO, ITALY
SN 1722-6996
EI 2035-4606
J9 AGRO FOOD IND HI TEC
JI Agro Food Ind. Hi-Tech
PD JAN-FEB
PY 2007
VL 18
IS 1
BP 22
EP 26
PG 5
WC Biotechnology & Applied Microbiology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Food Science & Technology
GA 159RY
UT WOS:000245885200007
DA 2025-06-11
ER

PT J
AU Mangel, M
AF Mangel, M.
TI Environment, damage and senescence: modelling the life-history
   consequences of variable stress and caloric intake
SO FUNCTIONAL ECOLOGY
LA English
DT Review
DE life-history theory; hormesis; foetal programming; metabolic syndrome;
   damage; foraging
ID CATCH-UP GROWTH; FETAL ORIGINS HYPOTHESIS; DEVELOPMENTAL ORIGINS;
   ANTAGONISTIC PLEIOTROPY; DIETARY RESTRICTION; TRADE-OFFS; HORMESIS;
   LONGEVITY; MORTALITY; SPAN
AB 1. Senescence is intimately connected with physiological state, which is affected by the environment. Two aspects of the environment - stress and caloric intake - are investigated in the context of senescence, particularly in the context of repair of damage caused by endogenous and exogenous stressors.
   2. In a simple life-history model, the organism is characterized by size (affecting reproductive success) and accumulated damage (affecting survival) at age. The modelled organism experiences an imprinting period, at the end of which it estimates the level of food and damaging sources in the environment. From those, an optimal life history is determined, assuming that reproduction is an allometric function of size.
   3. The optimal life history involves a behavioural trait (intensity of foraging) and an allocation process (amount of energy allocated to repair of damage). Subsequent to the imprinting period, the organism lives experiencing levels of stress or caloric intake that differ from those during the imprinting period. The mismatch is such that either the caloric intake is greater post-imprinting than during imprinting or environmental stress is smaller post-imprinting that during imprinting.
   4. Since reproduction is given allometrically and the organism cannot shrink, there is no reproductive senescence. In all cases, mortality increases with age. Senescence is caused by accumulated damage and we focus on the allocation of potential growth to repair and environmental mismatch.
   5. In the case of stress mismatch, the general qualitative result is that both the optimal level of activity and the allocation to repair are greater than their values in the case of no mismatch and they are positively correlated. For caloric mismatch, during the post-imprinting period the intensity of foraging is greater than that predicted if there were no mismatches. However, we predict either a negative correlation between genes characterizing activity and repair (for small mismatch), no correlation (for moderate mismatch) or positive correlation (for large mismatch). Furthermore, caloric mismatch is predicted to lead to a considerable reduction in lifetime reproduction, but stress mismatch is predicted to induce an increase in stress resistance throughout life with little cost to lifetime reproduction.
C1 Univ Calif Santa Cruz, Dept Appl Math & Stat, Santa Cruz, CA 95064 USA.
C3 University of California System; University of California Santa Cruz
RP Mangel, M (corresponding author), Univ Calif Santa Cruz, Dept Appl Math & Stat, Santa Cruz, CA 95064 USA.
EM msmangel@ams.ucsc.edu
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NR 105
TC 34
Z9 38
U1 0
U2 36
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0269-8463
EI 1365-2435
J9 FUNCT ECOL
JI Funct. Ecol.
PD JUN
PY 2008
VL 22
IS 3
BP 422
EP 430
DI 10.1111/j.1365-2435.2008.01410.x
PG 9
WC Ecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology
GA 302BF
UT WOS:000255940400005
DA 2025-06-11
ER

PT J
AU Sugimoto, H
   Okada, K
   Shoda, J
   Warabi, E
   Ishige, K
   Ueda, T
   Taguchi, K
   Yanagawa, T
   Nakahara, A
   Hyodo, I
   Ishii, T
   Yamamoto, M
AF Sugimoto, Hirokazu
   Okada, Kosuke
   Shoda, Junichi
   Warabi, Eiji
   Ishige, Kazunori
   Ueda, Tetsuya
   Taguchi, Keiko
   Yanagawa, Toru
   Nakahara, Akira
   Hyodo, Ichinosuke
   Ishii, Tetsuro
   Yamamoto, Masayuki
TI Deletion of nuclear factor-E2-related factor-2 leads to rapid onset and
   progression of nutritional steatohepatitis in mice
SO AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
LA English
DT Article
DE Nrf2 gene-knockout mouse; transcription factor; methionine- and
   choline-deficient diet; oxidative stress; glutathione
ID NONALCOHOLIC FATTY LIVER; TRANSCRIPTION FACTOR NRF2; HEPATIC
   GENE-EXPRESSION; CHOLINE-DEFICIENT DIET; OXIDATIVE STRESS;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; NATURAL-HISTORY; CELL-SURVIVAL;
   SUBUNIT GENE
AB Sugimoto H, Okada K, Shoda J, Warabi E, Ishige K, Ueda T, Taguchi K, Yanagawa T, Nakahara A, Hyodo I, Ishii T, Yamamoto M. Deletion of nuclear factor-E2-related factor-2 leads to rapid onset and progression of nutritional steatohepatitis in mice. Am J Physiol Gastrointest Liver Physiol 298: G283-G294, 2010. First published November 19, 2009; doi:10.1152/ajpgi.00296.2009.-Oxidative stress is a critical mediator in liver injury of steatohepatitis. The transcription factor Nrf2 serves as a cellular stress sensor and is a key regulator for induction of hepatic detoxification and antioxidative stress systems. The involvement of Nrf2 in defense against the development of steatohepatitis remains unknown. We aimed to investigate the protective roles of Nrf2 in nutritional steatohepatitis using wild-type (WT) and Nrf2 gene-null (Nrf2-null) mice. WT and Nrf2-null mice were fed a methionine- and choline-deficient (MCD) diet for 3 and 6 wk, and the liver tissues were analyzed for pathology and for expression levels of detoxifying enzymes and antioxidative stress genes via the Nrf2 transcriptional pathway. In WT mice fed an MCD diet, Nrf2 was potently activated in the livers, and steatohepatitis did not develop over the observation periods. However, in Nrf2-null mice fed an MCD diet, the pathological state of the steatohepatitis was aggravated in terms of fatty changes, inflammation, fibrosis, and iron accumulation. In the livers of the Nrf2-null mice, oxidative stress was significantly increased compared with that of WT mice based on the increased levels of 4-hydroxy-2-nonenal and malondialdehyde. This change was associated with the decreased levels of glutathione, detoxifying enzymes, catalase, and superoxide dismutase activity. Correlating well with the liver pathology, the mRNA levels of factors involved in fatty acid metabolism, inflammatory cytokines, and fibrogenesis-related genes were significantly increased in the livers of the Nrf2-null mice. These findings demonstrate that Nrf2 deletion in mice leads to rapid onset and progression of nutritional steatohepatitis induced by an MCD diet. Activation of Nrf2 could be a promising target toward developing new options for prevention and treatment of steatohepatitis.
C1 [Shoda, Junichi] Univ Tsukuba, Grad Sch Comprehens Human Sci, Field Basic Sports Med, Tsukuba, Ibaraki 3058574, Japan.
   [Sugimoto, Hirokazu; Okada, Kosuke; Ishige, Kazunori; Nakahara, Akira; Hyodo, Ichinosuke] Univ Tsukuba, Grad Sch Comprehens Human Sci, Dept Gastroenterol, Tsukuba, Ibaraki 3058574, Japan.
   [Warabi, Eiji; Yanagawa, Toru; Ishii, Tetsuro] Univ Tsukuba, Grad Sch Comprehens Human Sci, Dept Mol & Cellular Physiol, Tsukuba, Ibaraki 3058574, Japan.
   [Ueda, Tetsuya] Mitsubishi Chem Medience, Medichem Business Segment, Pharmacodynam Grp, Drug Dev Serv Div,Itabashi Ku, Tokyo, Japan.
   [Taguchi, Keiko; Yamamoto, Masayuki] Tohoku Univ, Grad Sch Med, Dept Med Biochem, Sendai, Miyagi 980, Japan.
C3 University of Tsukuba; University of Tsukuba; University of Tsukuba;
   Tohoku University
RP Shoda, J (corresponding author), Univ Tsukuba, Grad Sch Comprehens Human Sci, Field Basic Sports Med, Tsukuba, Ibaraki 3058574, Japan.
EM shodaj@md.tsukuba.ac.jp
RI Yamamoto, Masayuki/A-4873-2010; Yanagawa, Toru/GYU-6448-2022
OI Yanagawa, Toru/0000-0003-0868-2563; Taguchi, Keiko/0000-0002-5798-0076
FU Ministry of Education, Culture, Sports, Science and Technology, Japan
   [21300275]; Grants-in-Aid for Scientific Research [21300275] Funding
   Source: KAKEN
FX This work was supported in part by Grants-in-Aid for Scientific Research
   from the Ministry of Education, Culture, Sports, Science and Technology,
   Japan (21300275).
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NR 45
TC 133
Z9 145
U1 0
U2 5
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0193-1857
EI 1522-1547
J9 AM J PHYSIOL-GASTR L
JI Am. J. Physiol.-Gastroint. Liver Physiol.
PD FEB
PY 2010
VL 298
IS 2
BP G283
EP G294
DI 10.1152/ajpgi.00296.2009
PG 12
WC Gastroenterology & Hepatology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Physiology
GA 547GW
UT WOS:000273875900017
PM 19926817
DA 2025-06-11
ER

PT J
AU Cardoso, GA
   Ribeiro, MD
   Ferreira, AP
   de Oliveira, Y
   Medeiros, TD
   de Sousa, BR
   Pereira, RD
   de Almeida, AE
   Filho, JM
   Silva, RSB
   Silva, AS
AF Cardoso, Glebia A.
   Ribeiro, Mateus D.
   Ferreira, Ana P.
   de Oliveira, Yohanna
   Medeiros, Thiago de O.
   de Sousa, Bruno R.
   Pereira, Reabias de A.
   de Almeida, Antonio E.
   Filho, Joao M.
   Brito Silva, Raquel S.
   Silva, Alexandre S.
TI Oxidative stress does not influence weight loss induced by aerobic
   training in adults: randomized clinical trials
SO JOURNAL OF SPORTS MEDICINE AND PHYSICAL FITNESS
LA English
DT Article
DE Obesity; Body composition; Free radicals; Physiology; Exercise
ID EXERCISE INTERVENTIONS; ENERGY-EXPENDITURE; METABOLIC SYNDROME;
   PHYSICAL-ACTIVITY; RESISTANCE; WOMEN; MEN
AB BACKGROUND: High levels of oxidative stress promote degradation of the cell membrane impairing cellular function in fat oxidation. However, the influence of oxidative stress on exercise-induced weight-loss has not yet been investigated. Therefore, the aim of this study was to verify the influence of a lipidic peroxidation marker (malondialdehyde, MDA) and antioxidant status (total antioxidant capacity marker, TAC) on the magnitude of weight-loss by aerobic-induced exercise in previously sedentary overweight or obese individuals.
   METHODS: Seventy-five physically inactive adults were randomized into experimental (N.=58) and control (N.=17) groups, who engaged in a 12-week program of aerobic training walking and/or running (3 to 5 days/week) or stretching (1 day/week), respectively. Body composition (DXA), aerobic capacity (ergospirometric) and blood collections for oxidative stress analysis (MDA and TAC) were determined before and after the experimental protocol. Two-way ANOVA for repeated measures or Friedman's test were used to evaluate differences in time/group interaction. Pearson correlation was used to verify the relationship between the variables of oxidative stress and of body composition.
   RESULTS: Significant reduction was found in fat body mass of experimental when compared to control group (-1.3 +/- 1.9 kg versus -0.3 +/- 1.3, P=0.04). Experimental group also altered significantly the total body mass (-1.2 +/- 4.7 kg; effect size 0.44), body mass index - BMI (-0.3 +/- 1.1 effect size 0.37), fat percentage (1.3 +/- 1.6%; effect size 0.50) and lean body mass (0.6 +/- 1.5 kg; effect size 0.32).There was increase in MDA of 2.3 mu mol/L to 2.7 mu mol/L (P=0.00), without changes to TAC (25.6 +/- 13.9% to 28.0 +/- 10.4%). No correlation was found between these variations in body composition with either the initial values of MDA and TAC or delta variation of these indicators of oxidative stress in response to the training program.
   CONCLUSIONS: Indicators of oxidative stress (MDA and TAC) does not influence the magnitude of weight-loss induced by aerobic training.
C1 [Cardoso, Glebia A.; Ribeiro, Mateus D.; Ferreira, Ana P.; Medeiros, Thiago de O.; de Sousa, Bruno R.; Pereira, Reabias de A.; Brito Silva, Raquel S.; Silva, Alexandre S.] Univ Fed Paraiba, Lab Appl Studies Phys Training Performance & Hlth, Dept Phys Educ, Joao Pessoa, PB, Brazil.
   [Cardoso, Glebia A.; Ribeiro, Mateus D.; Ferreira, Ana P.; Pereira, Reabias de A.; Brito Silva, Raquel S.; Silva, Alexandre S.] Univ Fed Paraiba, Dept Phys Educ, Joao Pessoa, PB, Brazil.
   [de Oliveira, Yohanna; de Sousa, Bruno R.; Silva, Alexandre S.] Fed Univ Paraiba PPGCN UFPB, Joao Pessoa, PB, Brazil.
   [de Almeida, Antonio E.; Filho, Joao M.] Fed Univ Paraiba UFPB, Lauro Wanderley Univ Hosp HULW, Joao Pessoa, PB, Brazil.
C3 Universidade Federal da Paraiba; Universidade Federal da Paraiba;
   Universidade Federal da Paraiba
RP Silva, AS (corresponding author), Univ Fed Paraiba, Lab Appl Studies Phys Training Performance & Hlth, Dept Phys Educ, Ctr Ciencias Saude, Campus 1,Cidade Univ, BR-58059900 Joao Pessoa, PB, Brazil.
EM alexandresergiosilva@yahoo.com.br
RI de Andrade Pereira, Reabias/ABC-4652-2020; ribeiro,
   mateus/HZJ-3868-2023; Silva, Alexandre Sergio/N-8883-2014
OI Cardoso, Glebia Alexa/0000-0003-4822-1673; Sousa,
   Bruno/0000-0003-2026-5025; Duarte Ribeiro, Mateus/0000-0003-1071-5264;
   Silva, Alexandre Sergio/0000-0003-3576-9023
CR American Heart Association, 1972, EX TEST TRAIN APP HL
   [Anonymous], J DIABETES METAB DIS
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NR 24
TC 1
Z9 1
U1 0
U2 7
PU EDIZIONI MINERVA MEDICA
PI TURIN
PA CORSO BRAMANTE 83-85 INT JOURNALS DEPT., 10126 TURIN, ITALY
SN 0022-4707
EI 1827-1928
J9 J SPORT MED PHYS FIT
JI J. Sports Med. Phys. Fit.
PD JUN
PY 2020
VL 60
IS 6
BP 875
EP 882
DI 10.23736/S0022-4707.20.10528-0
PG 8
WC Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Sport Sciences
GA LW1WJ
UT WOS:000538936600010
PM 32487982
DA 2025-06-11
ER

PT J
AU Pividori, I
   Peric, T
   Comin, A
   Cotticelli, A
   Corazzin, M
   Prandi, A
   Mascolo, MD
AF Pividori, Isabella
   Peric, Tanja
   Comin, Antonella
   Cotticelli, Alessio
   Corazzin, Mirco
   Prandi, Alberto
   Mascolo, Massimo Domenico
TI Hair Cortisol/DHEA-S Ratios in Healthcare Workers and Their Patients
   During the COVID-19 Pandemic: A Case Study
SO LIFE-BASEL
LA English
DT Article
DE COVID-19; hair cortisol/dehydroepiandrosterone sulfate; hair; healthcare
   workers; neurological degenerative diseases
ID DEHYDROEPIANDROSTERONE-SULFATE; DHEA-S; METABOLIC SYNDROME; CHRONIC
   STRESS; IMPACT; ASSOCIATIONS; ADAPTATION; EXERCISE; HORMONES; HUMANS
AB Background: Unlike psychological distress, which has been extensively studied during the COVID-19 pandemic, the impact of the pandemic on stress hormones has been overlooked. The aim of this study is to examine the hair cortisol/dehydroepiandrosterone sulfate (DHEA-S) ratios as markers of HPA axis dysregulation in healthcare workers and their patients. Methods: A total of 200 healthcare workers and 161 "patients" patients with special healthcare needs due to chronic illness or motor disabilities were included in this study. The hormone concentrations were measured using a radioimmunoassay. Results: Our results show that the patients had significantly higher cortisol/DHEA-S ratios than the workers. A high cortisol/DHEA-S ratio in the patients reflects higher cortisol concentrations (p < 0.001) and lower DHEA-S (p < 0.05) concentrations compared to those of the healthcare workers, suggesting that they may be exposed to a greater degree of stress and a decrease in their ability to cope with their disease. The cut-off value of the hair cortisol/DHEA-S ratio in our study for detecting people with needs that require special consideration and attention was 1.46 (p <= 0.01). Conclusions: Assessing the hair cortisol/DHEA-S ratios in both healthcare workers and the patients allowed us to identify a non-homeostatic condition that could lead to disease and to understand psychophysical well-being during the COVID-19 pandemic. They also play a crucial role in preventive and personalized medicine.
C1 [Pividori, Isabella; Peric, Tanja; Comin, Antonella; Corazzin, Mirco; Prandi, Alberto] Univ Udine, Dept Agr Food Environm & Anim Sci, I-33100 Udine, Italy.
   [Cotticelli, Alessio] Univ Naples Federico II, Dept Vet Med & Anim Prod, I-80137 Naples, Italy.
   [Mascolo, Massimo Domenico] Hosp San Giorgio, Dept Neurol, Via Gemelli 10, I-33170 Pordenone, Italy.
C3 University of Udine; University of Naples Federico II
RP Corazzin, M (corresponding author), Univ Udine, Dept Agr Food Environm & Anim Sci, I-33100 Udine, Italy.
EM isabella.pividori@uniud.it; tanja.peric@uniud.it;
   antonella.comin@uniud.it; alessio.cotticelli@unina.it;
   mirco.corazzin@uniud.it; alberto.prandi@uniud.it;
   neuro@massimomascolo.it
RI Peric, Tanja/AAD-2990-2022
OI Peric, Tanja/0000-0002-5154-4222; Pividori,
   Isabella/0000-0003-2972-7804; CORAZZIN, Mirco/0000-0002-6921-3210
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NR 59
TC 0
Z9 0
U1 1
U2 1
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2075-1729
J9 LIFE-BASEL
JI Life-Basel
PD DEC
PY 2024
VL 14
IS 12
AR 1582
DI 10.3390/life14121582
PG 12
WC Biology; Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics; Microbiology
GA Q8S1E
UT WOS:001387295700001
PM 39768290
OA gold
DA 2025-06-11
ER

PT J
AU Kaneva, AM
   Bojko, ER
AF Kaneva, Anastasiya M.
   Bojko, Evgeny R.
TI Fatty liver index (FLI): more than a marker of hepatic steatosis
SO JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
LA English
DT Review
DE Fatty liver index; Hepatic steatosis; Insulin resistance; Inflammation;
   Oxidative stress
ID SERUM VITAMIN-D; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   NATIONAL-HEALTH; MUSCLE MASS; DISEASE; RISK; ASSOCIATION; POPULATION;
   ATHEROSCLEROSIS
AB Fatty liver index (FLI) was developed as a simple and accurate marker of hepatic steatosis. FLI is derived from an algorithm based on body mass index, waist circumference, and levels of triglycerides and gamma-glutamyltransferase, and it is widely used in clinical and epidemiological studies as a screening tool for discriminating between healthy and nonalcoholic fatty liver disease (NAFLD) subjects. However, a systematic review of the literature regarding FLI revealed that this index has more extensive relationships with biochemical and physiological parameters. FLI is associated with key parameters of lipid, protein and carbohydrate metabolism, hormones, vitamins and markers of inflammation, or oxidative stress. FLI can be a predictor or risk factor for a number of metabolic and nonmetabolic diseases and mortality. FLI is also used as an indicator for determining the effects of health-related prevention interventions, medications, and toxic substances on humans. Although in most cases, the exact mechanisms underlying these associations have not been fully elucidated, they are most often assumed to be mediated by insulin resistance, inflammation, and oxidative stress. Thus, FLI may be a promising marker of metabolic health due to its multiple associations with parameters of physiological and pathological processes. In this context, the present review summarizes the data from currently available literature on the associations between FLI and biochemical variables and physiological functions. We believe that this review will be of interest to researchers working in this area and can provide new perspectives and directions for future studies on FLI.
C1 [Kaneva, Anastasiya M.; Bojko, Evgeny R.] Russian Acad Sci, Inst Physiol, omi Sci Ctr, Ural Branch, 50 Pervomayskaya Str, Syktyvkar 167982, Russia.
C3 Russian Academy of Sciences; Institute of Physiology, Komi Scientific
   Center of the Russian Academy of Sciences
RP Kaneva, AM (corresponding author), Russian Acad Sci, Inst Physiol, omi Sci Ctr, Ural Branch, 50 Pervomayskaya Str, Syktyvkar 167982, Russia.
EM amkaneva@mail.ru
RI Bojko, Evgeny/G-4616-2016; Kaneva, Anastasiya/I-5936-2016
OI Bojko, Evgeny/0000-0002-8027-898X; Kaneva,
   Anastasiya/0000-0002-7789-4300
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NR 184
TC 22
Z9 24
U1 0
U2 7
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1138-7548
EI 1877-8755
J9 J PHYSIOL BIOCHEM
JI J. Physiol. Biochem.
PD FEB
PY 2024
VL 80
IS 1
BP 11
EP 26
DI 10.1007/s13105-023-00991-z
EA OCT 2023
PG 16
WC Biochemistry & Molecular Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Physiology
GA FS1R1
UT WOS:001088184400001
PM 37875710
DA 2025-06-11
ER

PT J
AU Park, J
   Kim, NH
   Yi, HJ
   Rhee, SG
   Woo, HA
AF Park, Jiyoung
   Kim, Nam Hee
   Yi, Ho Jin
   Rhee, Sue Goo
   Woo, Hyun Ae
TI Mitochondrial Peroxiredoxin III Protects against Non-Alcoholic Fatty
   Liver Disease Caused by a Methionine-Choline Deficient Diet
SO ANTIOXIDANTS
LA English
DT Article
DE peroxiredoxin III; reactive oxygen species; non-alcoholic fatty liver
   disease; methionine-choline deficient diet
ID HEPATIC STEATOSIS; OXIDATIVE STRESS; ANIMAL-MODELS; MAMMALIAN
   PEROXIREDOXIN; INSULIN-RESISTANCE; STEATOHEPATITIS; PROGRESSION;
   MECHANISMS; NASH; PATHOGENESIS
AB Non-alcoholic fatty liver disease (NAFLD) is emerging as the most common chronic liver disease worldwide. In addition, NAFLD may increase the risk of cardiovascular and liver-related diseases, and displays features of metabolic syndrome. In NAFLD, oxidative stress is primarily caused by excessive free fatty acids. The oxidation of fatty acids is usually caused by beta-oxidation of mitochondria under normal conditions, resulting in the production of energy. However, when the inflow of fatty acids in NAFLD becomes excessive, the beta-oxidation of mitochondria becomes saturated and the oxidation process increases at sites including peroxisomes and microsomes, thereby increasing production of reactive oxygen species (ROS). Thus, hepatic mitochondrial ROS play an important role in the pathogenesis of NAFLD. Eliminating mitochondrial ROS may improve NAFLD, but the underlying mechanism remains unclear. We examined the effect of mitochondrial ROS on NAFLD by focusing on peroxiredoxin (Prx), an antioxidant protein that can remove hydrogen peroxide. The protective effect and pathological phenomenon of mitochondrial peroxiredoxin in methionine-choline deficient diet (MCD)-induced liver injury was assessed in a mouse model of NAFLD. In these mice, mitochondrial peroxiredoxin deficiency significantly increased hepatic steatosis and fibrosis. In addition, ablation of Prx III enhances susceptibility to MCD diet-induced oxidative stress and exacerbates NAFLD progression by promoting inflammation. The binding assay results also showed that Prx III-deficient mice had more severe liver damage than Prx III-abundant mice in MCD diet liver injury models. The present data suggest that mitochondrial peroxiredoxin III could be a therapeutic target for preventing and suppressing diet-induced NAFLD.
C1 [Park, Jiyoung; Kim, Nam Hee; Woo, Hyun Ae] Ewha Womans Univ, Coll Pharm, Grad Sch Pharmaceut Sci, Seoul 120750, South Korea.
   [Park, Jiyoung] Ewha Womans Univ, Fluorescence Core Imaging Ctr, Dept Life Sci, Seoul 120750, South Korea.
   [Yi, Ho Jin; Woo, Hyun Ae] Ewha Womans Univ, Coll Pharm, Grad Sch Appl Sci & Technol Skin Hlth & Aesthet, Seoul 120750, South Korea.
   [Rhee, Sue Goo] NHLBI, Biochem & Biophys Ctr, NIH, Bethesda, MD 20892 USA.
C3 Ewha Womans University; Ewha Womans University; Ewha Womans University;
   National Institutes of Health (NIH) - USA; NIH National Heart Lung &
   Blood Institute (NHLBI)
RP Woo, HA (corresponding author), Ewha Womans Univ, Coll Pharm, Grad Sch Pharmaceut Sci, Seoul 120750, South Korea.; Woo, HA (corresponding author), Ewha Womans Univ, Coll Pharm, Grad Sch Appl Sci & Technol Skin Hlth & Aesthet, Seoul 120750, South Korea.
EM hawoo@ewha.ac.kr
RI Woo, Hyun/AAT-9586-2021; Juyoung, Park/LMQ-3664-2024
OI park, jiyoung/0000-0003-1846-2652
FU National Research Foundation of Korea [2021R1A2C2095037,
   2021R1C1C2006086 _]; Korea Basic Science Institute - Ministry of
   Education [2021R1A6C103A408, 2019R1A6C1010020]
FX This research was funded by grants from the National Research Foundation
   of Korea (2021R1A2C2095037 H.A.W was supported to Mid-career Research
   Grant and 2021R1C1C2006086 _Sejong Science Fellowship_SSF (J.P was
   supported to SSF)) and the Korea Basic Science Institute (National
   Research Facilities and Equipment Center) funded by the Ministry of
   Education (2021R1A6C103A408, 2019R1A6C1010020).
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NR 42
TC 2
Z9 2
U1 1
U2 16
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD JAN
PY 2023
VL 12
IS 1
AR 9
DI 10.3390/antiox12010009
PG 17
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA 8B0EA
UT WOS:000916604800001
PM 36670871
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Wang, WL
   Hu, L
   Chang, SM
   Ma, LS
   Li, XC
   Yang, Z
   Du, CL
   Qu, XM
   Zhang, CM
   Wang, SL
AF Wang, Weili
   Hu, Liang
   Chang, Shimin
   Ma, Linsha
   Li, Xiangchun
   Yang, Zi
   Du, Conglin
   Qu, Xingmin
   Zhang, Chunmei
   Wang, Songlin
TI Total body irradiation-induced colon damage is prevented by
   nitrate-mediated suppression of oxidative stress and homeostasis of the
   gut microbiome
SO NITRIC OXIDE-BIOLOGY AND CHEMISTRY
LA English
DT Article
DE Nitrate; Total body irradiation; Colonic mucosa; Oxidative stress
   injury; Gut microbiome
ID INFLAMMATORY-BOWEL-DISEASE; STEM-CELL TRANSPLANTATION; NITRIC-OXIDE;
   METABOLIC SYNDROME; FREE-RADICALS; RADIATION; SENESCENCE; EXPRESSION;
   SOCIETY; HEALTH
AB Inorganic dietary nitrate plays vital roles in biological functions via the exogenous NO3(-)/NO2(-)/NO pathway under hypoxia and ischemia. We previously verified the antioxidative effects of inorganic nitrate in a mouse model of total body irradiation (FBI). Accordingly, in this study, we evaluated the effects of inorganic nitrate on prevention of TBI-induced colon injury and dysbiosis of the gut microbiome. Nitrate significantly rescued the abnormal biological indexes (body weight, white blood cell, red blood cell, platelet, hemoglobin level and intestinal canal lengths) induced by TBI. Then, we detected oxidative stress and DNA damage indexes (phosphohistone H2AX and p53 binding protein 1), which were both increased by irradiation (IR) and alleviated by nitrate. IR-induced apoptosis and senescence were ameliorated by inorganic nitrate. The distribution of the gut microbiome differed for mice with TBI and those receiving inorganic nitrate. The average abundance of Lactobacillus significantly increased, and that of Bacteroidales decreased at the genus level in the nitrate group compared with that in the IR alone group. At 30 days after TBI, the abundances of Bacteroides and Faecalibaculum decreased, whereas that of Lactobacillus increased in the IR + nitrate group compared with that in the IR alone group. Inorganic nitrate efficiently prevents TBI-induced colon epithelium injury and maintains the homeostasis of the gut microbiome. Thus, our results showed that inorganic nitrate might be a promising treatment for TBI induced colon injury.
C1 [Wang, Weili; Hu, Liang; Chang, Shimin; Ma, Linsha; Li, Xiangchun; Yang, Zi; Du, Conglin; Qu, Xingmin; Zhang, Chunmei; Wang, Songlin] Capital Med Univ, Salivary Gland Dis Ctr, Sch Stomatol, Tian Tan Xi Li 4, Beijing 100050, Peoples R China.
   [Wang, Weili; Hu, Liang; Chang, Shimin; Ma, Linsha; Li, Xiangchun; Yang, Zi; Du, Conglin; Qu, Xingmin; Zhang, Chunmei; Wang, Songlin] Capital Med Univ, Beijing Key Lab Tooth Regenerat & Funct Reconstru, Sch Stomatol, Tian Tan Xi Li 4, Beijing 100050, Peoples R China.
   [Wang, Weili] Aerosp Ctr Hosp, Dept Stomatol, Beijing, Peoples R China.
   [Hu, Liang] Capital Med Univ, Sch Stomatol, Outpatient Dept Oral & Maxillofacial Surg, Beijing, Peoples R China.
   [Chang, Shimin; Ma, Linsha] Capital Med Univ, Beijing Friendship Hosp, Dept Stomatol, Beijing, Peoples R China.
   [Li, Xiangchun] First Hosp Qinhuangdao, Dept Stomatol, Qinhuangdao, Hebei, Peoples R China.
   [Wang, Songlin] Capital Med Univ, Dept Biochem & Mol Biol, Sch Basic Med, Beijing, Peoples R China.
   [Zhang, Chunmei; Wang, Songlin] Capital Med Univ, Beijing Friendship Hosp, Immunol Res Ctr Oral & Syst Hlth, Beijing, Peoples R China.
C3 Capital Medical University; Capital Medical University; Capital Medical
   University; Capital Medical University; Capital Medical University;
   Capital Medical University
RP Wang, SL (corresponding author), Capital Med Univ, Salivary Gland Dis Ctr, Sch Stomatol, Tian Tan Xi Li 4, Beijing 100050, Peoples R China.; Wang, SL (corresponding author), Capital Med Univ, Beijing Key Lab Tooth Regenerat & Funct Reconstru, Sch Stomatol, Tian Tan Xi Li 4, Beijing 100050, Peoples R China.
EM slwang@ccmu.edu.cn
RI Zhang, Chunmei/AAE-3845-2022; Li, Xiangchun/X-8118-2019
OI hu, liang/0000-0002-3955-7530
FU National Natural Science Foundation of China [91649124]; School
   excellent doctoral thesis advisor support project of Capital Medical
   University [0900-19000202]; Chinese Academy of Medical Sciences Research
   Unit, Capital Medical University [2019RU020]; Beijing Municipal Science
   & Technology Commission [Z181100001718208]; Beijing Municipal Education
   Commission [119207020201]; Beijing Municipality Government (Beijing
   Scholar Program) [PXM2018_014226_000021, PXM2017_014226_000023,
   PXM2018_193312_000006_0028S643_FCG, SML20151401]
FX This study was supported by grants from National Natural Science
   Foundation of China (91649124) and School excellent doctoral thesis
   advisor support project of Capital Medical University (0900-19000202);
   Chinese Academy of Medical Sciences Research Unit (No. 2019RU020),
   Capital Medical University; Beijing Municipal Science & Technology
   Commission No.Z181100001718208; Beijing Municipal Education Commission
   No. 119207020201; and grants from Beijing Municipality Government
   (Beijing Scholar Program-PXM2018_014226_000021, PXM2017_014226_000023,
   PXM2018_193312_000006_0028S643_FCG and SML20151401).
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NR 55
TC 17
Z9 18
U1 0
U2 24
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 1089-8603
EI 1089-8611
J9 NITRIC OXIDE-BIOL CH
JI Nitric Oxide-Biol. Chem.
PD SEP 1
PY 2020
VL 102
BP 1
EP 11
DI 10.1016/j.niox.2020.05.002
PG 11
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA MN9MY
UT WOS:000551165000001
PM 32470598
OA hybrid
DA 2025-06-11
ER

PT J
AU Farkhondeh, T
   Samarghandian, S
   Azimi-Nezhad, M
AF Farkhondeh, Tahereh
   Samarghandian, Saeed
   Azimi-Nezhad, Mohsen
TI The role of arsenic in obesity and diabetes
SO JOURNAL OF CELLULAR PHYSIOLOGY
LA English
DT Review
DE apoptosis; arsenic; diabetes; inflammation; obesity; oxidative stress
ID ADIPOSE-TISSUE DYSFUNCTION; OXIDATIVE STRESS; METABOLIC SYNDROME;
   DRINKING-WATER; LOW-LEVEL; GLUCOSE-INTOLERANCE; INSULIN-RESISTANCE;
   NATIONAL-HEALTH; EXPOSURE; LEAD
AB As many individuals worlwide are exposed to arsenic, it is necessary to unravel the role of arsenic in the risk of obesity and diabetes. Therefore, the present study reviewed the effects of arsenic exposure on the risk and potential etiologic mechanisms of obesity and diabetes. It has been suggested that inflammation, oxidative stress, and apoptosis contribute to the pathogenesis of arsenic-induced diabetes and obesity. Though arsenic is known to cause diabetes through different mechanisms, the role of adipose tissue in diabetes is still unclear. This review exhibited the effects of arsenic on the metabolism and signaling pathways within adipose tissue (such as sirtuin 3 [SIRT3]- forkhead box O3 [FOXO3a], mitogen-activated protein kinase [MAPK], phosphoinositide-dependant kinase-1 [PDK-1], unfolded protein response, and C/EBP homologous protein [CHOP10]). Different types of adipokines involved in arsenic-induced diabetes are yet to be elucidated. Arsenic exerts negative effects on the white adipose tissue by decreasing adipogenesis and enhancing lipolysis. Some epidemiological studies have shown that arsenic can promote obesity. Nevertheless, few studies have indicated that arsenic may induce lipodystrophy. Arsenic multifactorial effects include accelerating birth and postnatal weight gains, elevated body fat content, glucose intolerance, insulin resistance, and increased serum lipid profile. Arsenic also elevated cord blood and placental, as well as postnatal serum leptin levels. The data from human studies indicate an association between inorganic arsenic exposure and the risk of diabetes and obesity. However, the currently available evidence is insufficient to conclude that low-moderate dose arsenic is associated with diabetes or obesity development. Therefore, more investigations are needed to determine biological mechanisms linking arsenic exposure to obesity and diabetes.
C1 [Farkhondeh, Tahereh] Birjand Univ Med Sci, Cardiovasc Dis Res Ctr, Birjand, Iran.
   [Samarghandian, Saeed; Azimi-Nezhad, Mohsen] Neyshabur Univ Med Sci, Dept Basic Med Sci, Neyshabur 1413993186, Iran.
C3 Birjand University of Medical Sciences
RP Samarghandian, S (corresponding author), Neyshabur Univ Med Sci, Dept Basic Med Sci, Neyshabur 1413993186, Iran.
EM samarghandians1@nums.ac.ir
RI Farkhondeh, Tahereh/Y-2083-2018
OI , Saeed/0000-0001-5461-9579; farkhondeh, tahereh/0000-0002-9579-8339
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NR 97
TC 74
Z9 82
U1 1
U2 60
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0021-9541
EI 1097-4652
J9 J CELL PHYSIOL
JI J. Cell. Physiol.
PD AUG
PY 2019
VL 234
IS 8
BP 12516
EP 12529
DI 10.1002/jcp.28112
PG 14
WC Cell Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Physiology
GA HX2SA
UT WOS:000467240800034
PM 30667058
DA 2025-06-11
ER

PT J
AU Petelin, A
   Kenig, S
   Kopinc, R
   Dezelak, M
   Bizjak, MC
   Praznikar, ZJ
AF Petelin, Ana
   Kenig, Sasa
   Kopinc, Rok
   Dezelak, Matjaz
   Bizjak, Masa Cernelic
   Praznikar, Zala Jenko
TI Effects of Royal Jelly Administration on Lipid Profile, Satiety,
   Inflammation, and Antioxidant Capacity in Asymptomatic Overweight Adults
SO EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Article
ID OXIDATIVE STRESS; INSULIN-RESISTANCE; WEIGHT-GAIN; IN-VITRO; OBESITY;
   SUPPLEMENTATION; LEPTIN; IMPROVES; DIETARY; PROTEIN
AB Objectives. Obesity and overweight are chronic disorders of multifactorial origin that are characterized by high oxidative status and by chronic activation of macrophages in peripheral tissues. Effective therapeutic approaches to lower inflammation and oxidative stress are currently of general interest. Royal jelly (RJ) is a functional food with a broad range of pharmacological activities, mainly used by healthy individuals or borderline patients to protect themselves against disease onset. The objective of this randomized, double-blind, placebo-controlled trial was to investigate the effects of RJ supplementation on metabolic profile and oxidative and inflammatory parameters in asymptomatic overweight adults, considered at an early stage of developing metabolic syndrome. Material and Methods. The experimental group (n=30) was given RJ and the control group (n=30) was provided with a placebo for eight weeks. Anthropometric, biochemical parameters, biomarkers of oxidative stress, and inflammation were assessed at baseline, after 4 and 8 weeks of the intervention, and after additional 2 weeks of follow up. Results and Conclusion. Compared with the placebo, RJ supplementation demonstrated a statistically significant decrease in total cholesterol (6.7%; p=0.041) and inflammatory marker C-reactive protein (19%; p=0.027), whereas significant increases were observed in anti-inflammatory marker adiponectin (34%; p=0.011), endogenous antioxidants bilirubin (35%; p=0.002) and uric acid (5%; p=0.018), total antioxidant capacity in serum (54%; p=0.005), and leptin (17%; p=0.025). The present study demonstrated positive effects of RJ administration on lipid profile, satiety, inflammation, and antioxidant capacity in overweight adults. Therefore, our study supports the benefits of RJ supplementation for the improvement of human health.
C1 [Petelin, Ana; Kenig, Sasa; Bizjak, Masa Cernelic; Praznikar, Zala Jenko] Univ Primorska, Fac Hlth Sci, Polje 42, SI-6310 Izola, Slovenia.
   [Kopinc, Rok; Dezelak, Matjaz] Medex Doo, Linhartova 49A, SI-1000 Ljubljana, Slovenia.
C3 University of Primorska
RP Praznikar, ZJ (corresponding author), Univ Primorska, Fac Hlth Sci, Polje 42, SI-6310 Izola, Slovenia.
EM zala.praznikar@upr.si
RI Kenig, Sasa/LDE-6578-2024; Petelin, Ana/GLV-1610-2022; Dezelak,
   Matjaz/H-3935-2011; Jenko Praznikar, Zala/KVX-9901-2024
OI Kenig, Sasa/0000-0003-4272-3058; Cernelic-Bizjak,
   Masa/0000-0002-0537-0196; Petelin, Ana/0000-0002-5557-5974; Dezelak,
   Matjaz/0000-0002-9298-4582; Jenko Praznikar, Zala/0000-0002-5217-8754
FU Republic of Slovenia Ministry of Education, Science, and Sport; European
   Union from European Social Funds; Slovenian Research Agency [P1-0386,
   J3-8209]
FX The authors would like to thank all the subjects for volunteering in
   this study, students, and nurses of the Faculty of Health Sciences. The
   study was funded by the Republic of Slovenia Ministry of Education,
   Science, and Sport and European Union from European Social Funds. This
   work was also supported by the Slovenian Research Agency (Programme
   P1-0386 and Research Project J3-8209).
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NR 53
TC 39
Z9 39
U1 1
U2 5
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1741-427X
EI 1741-4288
J9 EVID-BASED COMPL ALT
JI Evid.-based Complement Altern. Med.
PY 2019
VL 2019
AR 4969720
DI 10.1155/2019/4969720
PG 11
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA IF3RR
UT WOS:000473001100001
PM 31312222
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Ndrepepa, G
AF Ndrepepa, Gjin
TI Uric acid and cardiovascular disease
SO CLINICA CHIMICA ACTA
LA English
DT Review
DE Arterial hypertension; Atrial fibrillation; Coronary heart disease;
   Congestive heart failure; Mortality; Stroke; Uric acid
ID CORONARY-ARTERY-DISEASE; CHRONIC HEART-FAILURE;
   RENIN-ANGIOTENSIN-SYSTEM; ALL-CAUSE MORTALITY; XANTHINE-OXIDASE
   INHIBITION; SMOOTH-MUSCLE-CELLS; NUTRITION EXAMINATION SURVEY; ACTIVATED
   PROTEIN-KINASE; SERUM URATE LEVELS; OXIDATIVE STRESS
AB Uric acid (UA) is an end product of purine metabolism in humans and great apes. UA acts as an antioxidant and it accounts for 50% of the total antioxidant capacity of biological fluids in humans. When present in cytoplasm of the cells or in acidic/hydrophobic milieu in atherosclerotic plaques, UA converts into a pro-oxidant agent and promotes oxidative stress and through this mechanism participates in the pathophysiology of human disease including cardiovascular disease (CVD). Most epidemiological studies but not all of them suggested the existence of an association between elevated serum UA level and CVD, including coronary heart disease (CHD), stroke, congestive heart failure, arterial hypertension and atrial fibrillation as well as an increased risk for mortality due to CVD in general population and subjects with confirmed CHD. Evidence available also suggests an association between elevated UA and traditional cardiovascular risk factors, metabolic syndrome, insulin resistance, obesity, non-alcoholic fatty liver disease and chronic kidney disease. Experimental and clinical studies have evidenced several mechanisms through which elevated UA level exerts deleterious effects on cardiovascular health including increased oxidative stress, reduced availability of nitric oxide and endothelial dysfunction, promotion of local and systemic inflammation, vasoconstriction and proliferation of vascular smooth muscle cells, insulin resistance and metabolic dysregulation. Although the causality in the relationship between UA and CVD remains unproven, UA may be pathogenic and participate in the pathophysiology of CVD by serving as a bridging mechanism mediating (enabling) or potentiating the deleterious effects of cardiovascular risk factors on vascular tissue and myocardium.
C1 [Ndrepepa, Gjin] Tech Univ, Dept Adult Cardiol, Deutsch Herzzentrum Munchen, Munich, Germany.
C3 German Heart Centre Munich; Technical University of Munich
RP Ndrepepa, G (corresponding author), Deutsch Herzzentrum Munich, Lazarettstr 36, D-80636 Munich, Germany.
EM ndrepepa@dhm.mhn.de
OI Ndrepepa, Gjin/0000-0002-8725-055X
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NR 213
TC 354
Z9 377
U1 7
U2 106
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0009-8981
EI 1873-3492
J9 CLIN CHIM ACTA
JI Clin. Chim. Acta
PD SEP
PY 2018
VL 484
BP 150
EP 163
DI 10.1016/j.cca.2018.05.046
PG 14
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA GO6CF
UT WOS:000440121000025
PM 29803897
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Agirbasli, M
   Tanrikulu, A
   Erkus, E
   Azizy, M
   Acar Sevim, B
   Kaya, Z
   Taskin, A
   Aksoy, N
   Demirbag, R
AF Agirbasli, Mehmet
   Tanrikulu, Azra
   Erkus, Emre
   Azizy, Munir
   Acar Sevim, Busra
   Kaya, Zekeriya
   Taskin, Abdullah
   Aksoy, Nurten
   Demirbag, Recep
TI Serum paraoxonase-1 activity in children: the effects of obesity and
   insulin resistance
SO ACTA CARDIOLOGICA
LA English
DT Article
DE Insulin resistance; oxidative stress; HDL-C; paraoxonase; children
ID LOW-DENSITY-LIPOPROTEIN; BODY-MASS INDEX; CARDIOVASCULAR RISK; METABOLIC
   SYNDROME; CHILDHOOD OBESITY; OXIDATIVE STRESS; TURKISH CHILDREN;
   DYSLIPIDEMIA; SENSITIVITY; OVERWEIGHT
AB Oxidative stress (OS) is important in the pathogenesis of atherosclerosis. Paraoxonase-1 (PON1) is an enzyme found in the circulation associated with high density lipoprotein (HDL). HDL-associated enzyme PON1 has an important role in the attenuation of atherogenic low density lipoprotein (LDL) oxidation. The aim of this study was to determine PON1 and arylesterase (AREST) enzyme levels in relation to insulin resistance (IR) or obesity among children and adolescents. The study included healthy school children and adolescents. Blood was drawn for the determination of blood glucose, lipid, PON1 and AREST enzyme levels. Overall, we observed a positive correlation between PON1 enzyme activity and high-density lipoprotein cholesterol (HDL-C) levels (r = 0.189, P = 0.014). The correlation appeared to be more significant in boys (r = 0.271, P = 0.009). For subjects with IR and obesity, PON1 enzyme activity did not correlate with HDL-C levels (r=0.038, P=0.790), instead PON1 levels correlated negatively with BMI (r = 0.309 and P=0.026). Multiple linear regression analysis was performed to find the predictors of log PON1 activity. HDL-C level was the strongest predictor of PON1 activity in the lean control group, while BMI appeared to be the strongest predictor in the subjects with obesity or IR. In conclusion, determinants of PON1 enzyme activity are variable in children and adolescents based on IR and obesity. Future studies will shed light on the underlying mechanisms and biomarkers of OS in children and may reveal possible targets for therapeutic intervention.
C1 [Agirbasli, Mehmet] Marmara Univ, Sch Med, Dept Cardiol, Istanbul, Turkey.
   [Tanrikulu, Azra] Maltepe State Hosp, Dept Cardiol, Istanbul, Turkey.
   [Erkus, Emre; Kaya, Zekeriya; Demirbag, Recep] Harran Univ, Dept Cardiol, Sanliurfa, Turkey.
   [Azizy, Munir; Acar Sevim, Busra] Marmara Univ, Sch Med, Istanbul, Turkey.
   [Taskin, Abdullah; Aksoy, Nurten] Harran Univ, Dept Biochem, Sanliurfa, Turkey.
C3 Marmara University; Maltepe State Hospital; Harran University; Marmara
   University; Harran University
RP Agirbasli, M (corresponding author), Yesilbahar Sok 68-14 Goztepe, TR-34726 Istanbul, Turkey.
EM magirbasli@gmail.com
RI Inan, Nurten/AAA-8197-2021; Erkuş, Emre/ABC-4126-2021; Agirbasli,
   Mehmet/AFP-1794-2022; Celikk, Hakim/ABF-5740-2020; Demirbag,
   Recep/Z-2369-2019
OI Demirbag, Recep/0000-0001-7831-2715
FU Scientific Research and Projects Commission of Marmara University
   (BAPKO)
FX The study was funded by the Scientific Research and Projects Commission
   of Marmara University (BAPKO).
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NR 34
TC 4
Z9 4
U1 0
U2 17
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0001-5385
EI 1784-973X
J9 ACTA CARDIOL
JI Acta Cardiol.
PD DEC
PY 2014
VL 69
IS 6
BP 679
EP 685
DI 10.1080/AC.69.6.1000011
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA AX5GM
UT WOS:000346954700011
PM 25643439
DA 2025-06-11
ER

PT J
AU Taguchi, I
   Toyoda, S
   Takano, K
   Arikawa, T
   Kikuchi, M
   Ogawa, M
   Abe, S
   Node, K
   Inoue, T
AF Taguchi, Isao
   Toyoda, Shigeru
   Takano, Kazuhiko
   Arikawa, Takuo
   Kikuchi, Migaku
   Ogawa, Mikie
   Abe, Shichiro
   Node, Koichi
   Inoue, Teruo
TI Irbesartan, an angiotensin receptor blocker, exhibits metabolic,
   anti-inflammatory and antioxidative effects in patients with high-risk
   hypertension
SO HYPERTENSION RESEARCH
LA English
DT Article
DE angiotensin receptor blocker; inflammation; irbesartan; lipid
   metabolism; oxidative stress
ID TELMISARTAN; NEPHROPATHY; ANTAGONIST; ACTIVATION; MECHANISMS; CYTOKINES;
   BENEFITS; INSULIN; SYSTEM
AB Irbesartan, an angiotensin II receptor blocker (ARB), acts as a selective PPAR-gamma (peroxisome proliferator-activated receptor-c) modulator, and thus may have anti-inflammatory and antioxidative effects, as well as beneficial effects on glucose and lipid metabolism. We enrolled 118 high-risk hypertensive outpatients, defined as those with the presence of at least one complication such as coronary artery disease, cerebrovascular disease or diabetes, and who were receiving any ARB except for irbesartan (67 +/- 10 years, 80% male subjects). After a 4-week control period, all ARBs were switched to an equivalent dose of irbesartan. We evaluated changes in lipid parameters, inflammatory markers and derivatives of reactive oxygen metabolites (d-ROMs) as an oxidative stress index. After 12 weeks of irbesartan, there were significant decreases in triglycerides (138 +/- 73 versus 123 +/- 65mg dl(-1), P<0.05), high-sensitivity C-reactive protein (hs-CRP) (2.80 +/- 0.53 versus 2.66 +/- 0.50, log (ng ml(-1)), P<0.05) and d-ROMs (338 +/- 74 versus 305 +/- 62 U. CARR, P<0.001). There were significant increases in high-density lipoprotein cholesterol (50 +/- 13 versus 52 +/- 14 mg dl(-1), P<0.01) and adiponectin (9.4 +/- 6.2 versus 16.6 +/- 13.4 ng ml(-1), P<0.05). There were no significant changes in systolic and diastolic blood pressure. The change in d-ROMs from baseline to 12 weeks was positively correlated with the change in hs-CRP (R = 0.34, P<0.01). Irbesartan appears to exert beneficial effects on oxidative stress, inflammation, lipid metabolism and metabolic syndrome, indicating that it may be useful in high-risk hypertensive patients.
C1 [Taguchi, Isao; Toyoda, Shigeru; Takano, Kazuhiko; Arikawa, Takuo; Kikuchi, Migaku; Ogawa, Mikie; Abe, Shichiro; Inoue, Teruo] Dokkyo Med Univ, Dept Cardiovasc Med, Mibu, Tochigi 3210293, Japan.
   [Node, Koichi] Saga Univ, Dept Cardiovasc Med, Saga 840, Japan.
C3 Dokkyo Medical University; Saga University
RP Taguchi, I (corresponding author), Dokkyo Med Univ, Dept Cardiovasc Med, 880 Kitakobayashi, Mibu, Tochigi 3210293, Japan.
EM taguchi@dokkyomed.ac.jp
FU Vehicle Racing Commemorative Foundation, Tokyo, Japan
FX This study was supported in part by grants from Vehicle Racing
   Commemorative Foundation, Tokyo, Japan. We acknowledge the technical
   support services of Ken-ichi Inoue, PhD and Ryoichi Sohma, PhD, Research
   Support Center, Dokkyo Medical University, Mibu, Tochigi, Japan.
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NR 35
TC 58
Z9 61
U1 1
U2 12
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0916-9636
EI 1348-4214
J9 HYPERTENS RES
JI Hypertens. Res.
PD JUL
PY 2013
VL 36
IS 7
BP 608
EP 613
DI 10.1038/hr.2013.3
PG 6
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 178EF
UT WOS:000321426300009
PM 23425956
OA Bronze
DA 2025-06-11
ER

PT J
AU Wang, XY
   Gong, LJ
   Wei, C
   Zhao, YA
   Ran, LY
   Li, PJ
   Gu, WY
   Wu, X
   Liang, ZA
   Wang, XY
AF Wang, Xinyu
   Gong, Linjing
   Wei, Chang
   Zhao, Yuean
   Ran, Longyi
   Li, Peijun
   Gu, Wenyu
   Wu, Xu
   Liang, Zongan
   Wang, Xinyuan
TI Inhibition of NSUN6 protects against intermittent hypoxia-induced
   oxidative stress and inflammatory response in adipose tissue through
   suppressing macrophage ferroptosis and M1 polarization
SO LIFE SCIENCES
LA English
DT Article
DE Obstructive sleep apnea; Chronic intermittent hypoxia; NSUN6; Adipose
   tissue inflammation; M1 macrophage polarization; Ferroptosis
ID OBSTRUCTIVE SLEEP-APNEA
AB Aims: Accumulating studies have demonstrated obstructive sleep apnea (OSA) is strongly associated with metabolic syndrome (MetS) and inflammatory response in adipose tissue. Chronic intermittent hypoxia (CIH) has been proved leading to M1 macrophage polarization that contributes to adipose tissue inflammation, but the molecular mechanism remains unclear. Epigenetic regulation of RNA has been found playing crucial roles in incremental diseases. Main methods: Based on mining the GEO database, we constructed an IH (8 weeks) C57/6 J mice model to investigate the changes and interactions of key gene expression, M1 macrophage infiltration, and inflammatory markers in white adipose tissue. We also used an IH-treated (24 h) RAW 264.7 cells to further explore the mechanisms of hypoxia-induced M1 polarization, oxidative stress, and inflammatory response. Key findings: According to the analysis of datasets, CIH increases the level of NSUN6 in adipose tissue and NSUN6 shows good diagnostic value of OSA. In the mice model, CIH exposure is also demonstrated to increases NSUN6 level and M1 macrophage infiltration in adipose tissue, which can be reversed by ferroptosis inhibitor. Studies show that CIH leads to ferroptosis and M1 macrophage polarization by promoting the expression of NSUN6 in vitro, thus resulting in inflammatory response. Significance: Our findings provide a better understanding of the mechanisms of CIH-induced inflammation in adipose tissue. NSUN6 is firstly suggested to participate in macrophages ferroptosis and M1 polarization. Inhibition of NSUN6 in macrophages could protects against CIH-induce oxidative stress and inflammatory response in adipose tissue, thus becoming a potential therapeutic target to OSA-associated MetS.
C1 [Wang, Xinyu; Gong, Linjing; Wei, Chang; Zhao, Yuean; Ran, Longyi; Li, Peijun; Liang, Zongan] Sichuan Univ, West China Hosp, Dept Resp & Crit Care Med, 37 Guoxue Alley, Chengdu 610041, Sichuan, Peoples R China.
   [Wang, Xinyu; Gong, Linjing; Wei, Chang; Zhao, Yuean; Ran, Longyi; Li, Peijun; Liang, Zongan] State Key Lab Resp Hlth & Multimorbid, Beijing, Peoples R China.
   [Gu, Wenyu] Tongji Univ, Shanghai Peoples Hosp 10, Sch Med, Dept Urol, 301 Yanchang Rd, Shanghai 200072, Peoples R China.
   [Wu, Xu] Fudan Univ, Zhongshan Hosp, Dept Pulm Med, Shanghai 200032, Peoples R China.
   [Wang, Xinyuan] Sichuan Univ, West China Hosp, Dept Orthopaed, 37 Guoxue Alley, Chengdu 610041, Sichuan, Peoples R China.
C3 Sichuan University; Tongji University; Fudan University; Sichuan
   University
RP Liang, ZA (corresponding author), Sichuan Univ, West China Hosp, Dept Resp & Crit Care Med, 37 Guoxue Alley, Chengdu 610041, Sichuan, Peoples R China.; Wang, XY (corresponding author), Sichuan Univ, West China Hosp, Dept Orthopaed, 37 Guoxue Alley, Chengdu 610041, Sichuan, Peoples R China.
EM liangza@scu.edu.cn; xywang_fdu@scu.edu.cn
FU National Natural Science Foundation of China [82200102]; Project of
   Sichuan Provincial Department of Science and Technology [2023NSFSC1464,
   2024YFFK0399, 2023NSFSC1468]; West China Hospital Postdoctoral Science
   Foundation [2023HXBH043]; Data Sharing and Emulation of Clinical Trials,
   CCS-DASET [SHDC2024CRI043];  [82202688];  [2023NSFSC1459]
FX The study was financially supported by the National Natural Science
   Foundation of China (Grant no. 82200102 & 82202688) , the Project of
   Sichuan Provincial Department of Science and Technology (2023NSFSC1464 &
   2023NSFSC1459 & 2024YFFK0399 & 2023NSFSC1468) , West China Hospital
   Postdoctoral Science Foundation (2023HXBH043) and Data Sharing and
   Emulation of Clinical Trials, CCS-DASET (SHDC2024CRI043) .
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NR 45
TC 0
Z9 0
U1 11
U2 11
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0024-3205
EI 1879-0631
J9 LIFE SCI
JI Life Sci.
PD MAR 1
PY 2025
VL 364
AR 123433
DI 10.1016/j.lfs.2025.123433
EA JAN 2025
PG 12
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA X4Y2D
UT WOS:001425415600001
PM 39884342
DA 2025-06-11
ER

PT J
AU Liu, XJ
   Lv, XB
   Ji, TC
   Hu, HY
   Chang, L
AF Liu, Xiaojin
   Lv, Xiaobing
   Ji, Tiancheng
   Hu, Haoya
   Chang, Lei
TI Gynostemma pentaphyllum Makino extract induces hair growth and
   exhibits an anti-graying effect via multiple mechanisms
SO JOURNAL OF COSMETIC DERMATOLOGY
LA English
DT Article
DE anti-graying; Gynostemma pentaphyllum Makino; hair growth; in vivo and
   in vitro experiments; mechanism of action
ID MELANOGENESIS; ANAGEN; MELANOCYTES; FOLLICLES; STRESS
AB Background: In traditional Asian medicine, Gynostemma pentaphyllum Makino leaf extract (Gp) is used to treat aging, metabolic syndrome, diabetes, and neurodegenerative diseases. Hair loss and hair-graying are common phenomena that haunt everyone. However, whether Gp activities on inhibition of hair loss and getting gray have been rarely studied.Aim: Study the Gp activity and mechanism by in vivo and in vitro experiments to explore its application on hair health.Methods: In the present study, we determined the effects of Gp on the expression of hair growth-related genes and proliferation of human dermal papilla cells (hDPCs). Furthermore, Gp was topically applied to the hair-shaved skin of male C57BL/6 mice, and the histological profile of the skin was studied. Because emotional stress may lead to melanocyte disappearance, norepinephrine-exposed mice B16 melanocytes were treated with Gp to elucidate the anti-hair graying capacity of Gp in response to this stress type.Results: Gp stimulated the proliferation of hDPCs and the Wnt signaling pathways associated with hair growth; furthermore, the expression of the hair loss-related gene transforming growth factor-beta 1 was suppressed. Gp treatment significantly increased the size of hair follicles in the treated mice and stimulated them. Moreover, Gp not only increased melanin synthesis but also tyrosinase activity in B16 cells. Quantitative real-time polymerase chain reaction revealed that Gp increased melanin synthesis by increasing the expression of tyrosine-related protein-1, tyrosine-related protein-2, tyrosinase, and microphthalmia-associated transcription factor.Conclusion: Our study provides preclinical evidence regarding the potential of Gp as a promising hair growth and anti-graying agent.
C1 [Liu, Xiaojin; Lv, Xiaobing; Ji, Tiancheng; Hu, Haoya; Chang, Lei] Anhui Normal Univ, Coll Life Sci, Anhui Prov Key Lab Mol Enzymol & Mech Major Dis, Wuhu, Peoples R China.
   [Liu, Xiaojin; Lv, Xiaobing; Ji, Tiancheng; Hu, Haoya; Chang, Lei] Anhui Normal Univ, Coll Life Sci, Anhui Prov Key Lab Conservat & Exploitat Biol Reso, Wuhu, Peoples R China.
C3 Anhui Normal University; Anhui Normal University
RP Liu, XJ (corresponding author), Anhui Normal Univ, Coll Life Sci, Anhui Prov Key Lab Mol Enzymol & Mech Major Dis, Wuhu, Peoples R China.
EM 6567323@qq.com
OI LIU, Xiaojin/0000-0002-6574-7856
FU This work was financially supported by the Outstanding Innovative
   Research Team for Molecular Enzymology and Detection in Anhui Provincial
   Universities (2022AH010012). [2022AH010012]; Outstanding Innovative
   Research Team for Molecular Enzymology and Detection in Anhui Provincial
   Universities
FX This work was financially supported by the Outstanding Innovative
   Research Team for Molecular Enzymology and Detection in Anhui Provincial
   Universities (2022AH010012).
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NR 44
TC 4
Z9 4
U1 4
U2 24
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1473-2130
EI 1473-2165
J9 J COSMET DERMATOL-US
JI J. Cosmet. Dermatol.
PD FEB
PY 2024
VL 23
IS 2
BP 648
EP 657
DI 10.1111/jocd.15963
EA AUG 2023
PG 10
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA GQ3J2
UT WOS:001080677400001
PM 37649302
OA hybrid
DA 2025-06-11
ER

PT J
AU Capuzzi, E
   Ossola, P
   Caldiroli, A
   Auxilia, AM
   Buoli, M
AF Capuzzi, Enrico
   Ossola, Paolo
   Caldiroli, Alice
   Auxilia, Anna Maria
   Buoli, Massimiliano
TI Malondialdehyde as a candidate biomarker for bipolar disorder: A
   meta-analysis
SO PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
LA English
DT Article
DE Malondialdehyde; Bipolar disorder; Biomarker; Oxidative stress;
   Meta-analysis
ID OXIDATIVE STRESS PARAMETERS; LIPID-PEROXIDATION; 1ST-EPISODE PSYCHOSIS;
   ANTIOXIDATIVE DEFENSE; METABOLIC SYNDROME; MOOD DISORDERS; PATHWAYS;
   MARKERS; LITHIUM; STAGE
AB Malondialdehyde (MDA) represents one of the final products of lipid peroxidation that is thought to be enhanced and accelerated in patients affected by bipolar disorder (BD). Purpose of the present article is to critically summarize the available data about MDA as a candidate biomarker for BD. First, we carried out a systematic review of the literature selecting those papers that evaluated MDA levels in BD. Then, we performed two separate meta-analyses: one of the studies that compared healthy controls (HC) with unmedicated BD and one with the studies that assessed MDA levels before and after treatment in BD, showing that bipolar patients experience more oxidative stress than healthy subjects and that treatment is effective in reducing MDA levels. In the first set of studies, we also explored through a meta-regression whether age, gender and experiencing an episode specifically influenced the difference between BD and HC in MDA levels. Bipolar patients compared to healthy subjects had higher MDA levels (SMD: 0.94, 95% CI: 0.23-1.64). Age (p < 0.01), gender (p < 0.01) and the presence of a current mood episode (p < 0.01) significantly influenced MDA plasma/serum levels. Specifically, studies that included more female, older subjects and more BD in euthymia were more likely to have higher MDA levels. Finally, patients after treatment had lower levels of MDA compared to baseline (SMD: -0.52, 95% CI: -0.85 -0.19). More studies are needed to draw definitive conclusions.
C1 [Capuzzi, Enrico; Caldiroli, Alice] Azienda Socio Sanit Terr Monza, Psychiat Dept, Via Pergolesi 33, I-20900 Monza, MB, Italy.
   [Ossola, Paolo] Univ Parma, Dept Med & Surg, Parma, Italy.
   [Auxilia, Anna Maria] Univ Milano Bicocca, Dept Med & Surg, Via Cadore 38, I-20900 Monza, MB, Italy.
   [Buoli, Massimiliano] Maggiore Policlin, Dept Neurosci & Mental Hlth, Fdn IRCCS CaGranda Osped, Via F Sforza 35, I-20122 Milan, Italy.
   [Buoli, Massimiliano] Univ Milan, Dept Pathophysiol & Transplantat, Milan, Italy.
C3 University of Parma; University of Milano-Bicocca; University of Milan
RP Capuzzi, E (corresponding author), Azienda Socio Sanit Terr Monza, Psychiat Dept, Via Pergolesi 33, I-20900 Monza, MB, Italy.
EM e.capuzzi1@campus.unimib.it
RI Capuzzi, Enrico/AEX-3621-2022; Caldiroli, Alice/KIY-5948-2024; Auxilia,
   Anna Maria/MEO-2390-2025; Ossola, Paolo/AAK-4765-2020; Buoli,
   Massimiliano/K-8509-2016; Caldiroli, Alice/O-6633-2017
OI Caldiroli, Alice/0000-0002-8493-0779; Auxilia, Anna
   Maria/0000-0002-8887-5818; CAPUZZI, ENRICO/0000-0001-8350-499X
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NR 67
TC 21
Z9 22
U1 0
U2 15
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0278-5846
EI 1878-4216
J9 PROG NEURO-PSYCHOPH
JI Prog. Neuro-Psychopharmacol. Biol. Psychiatry
PD MAR 8
PY 2022
VL 113
AR 110469
DI 10.1016/j.pnpbp.2021.110469
EA NOV 2021
PG 7
WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA WZ3ZO
UT WOS:000719909100002
PM 34740710
DA 2025-06-11
ER

PT J
AU Zyzelewicz, D
   Oracz, J
   Bojczuk, M
   Budryn, G
   Jurgonski, A
   Juskiewicz, J
   Zdunczyk, Z
AF Zyzelewicz, Dorota
   Oracz, Joanna
   Bojczuk, Malgorzata
   Budryn, Grazyna
   Jurgonski, Adam
   Juskiewicz, Jerzy
   Zdunczyk, Zenon
TI Effects of Raw and Roasted Cocoa Bean Extracts Supplementation on
   Intestinal Enzyme Activity, Biochemical Parameters, and Antioxidant
   Status in Rats Fed a High-Fat Diet
SO NUTRIENTS
LA English
DT Article
DE Theobroma cacao L; cocoa beans extracts; intestinal microbiota activity;
   antioxidant parameters; oxidative stress markers; lipid profile;
   metabolic dysfunction
ID THEOBROMA-CACAO L.; METABOLIC SYNDROME; OXIDATIVE STRESS; ENRICHED DIET;
   OBESITY; POLYPHENOLS; FOOD; FERMENTATION; PHENOLICS; PRODUCTS
AB The aim of the study was to analyze the influence of diet containing the polyphenol-rich material on intestinal enzyme activity, oxidative stress markers, lipid metabolism and antioxidant status of laboratory rats. The animals were fed high-fat diet supplemented with freeze-dried water extracts of raw and roasted cocoa beans of Forastero variety. The observed changes indicated the biological activity of polyphenols and other components of the prepared cocoa beans extracts (CBEs). The presence of raw and roasted CBEs in the diets diversified the activity of the enzymes of the cecal microflora of rats. Both CBEs beneficially affect the antioxidant status of the serum, even in relation to the control standard group. The experimental cocoa bean preparations showed no significant effect on the mass of rats' liver, heart, and kidneys, but varied some parameters of the antioxidant status of their organisms. The raw CBE in rats fed with the high-fat diet shows a high ability to inhibit lipid peroxidation in heart and more effectively increases hepatic reduced glutathione (GSH) concentrations compared to the roasted CBE, which did not show any significant effect. Moreover, supplementation with both CBEs significantly affects the volatile fatty acids concentration in the rats' cecum. Results of this study contribute to the evidence that dietary supplementation with raw and roasted CBEs can exert health-promoting effects, however further studies are necessary.
C1 [Zyzelewicz, Dorota; Oracz, Joanna; Bojczuk, Malgorzata; Budryn, Grazyna] Lodz Univ Technol, Inst Food Technol & Anal, Fac Biotechnol & Food Sci, PL-90924 Lodz, Poland.
   [Jurgonski, Adam; Juskiewicz, Jerzy; Zdunczyk, Zenon] Polish Acad Sci, Inst Anim Reprod & Food Res, Dept Biol Funct Food, PL-10748 Olsztyn, Poland.
C3 Lodz University of Technology; Polish Academy of Sciences; Institute of
   Animal Reproduction & Food Research of the Polish Academy of Sciences
RP Zyzelewicz, D (corresponding author), Lodz Univ Technol, Inst Food Technol & Anal, Fac Biotechnol & Food Sci, PL-90924 Lodz, Poland.
EM dorota.zyzelewicz@p.lodz.pl; joanna.oracz@p.lodz.pl;
   malgorzata.bojczuk@gmail.com; grazyna.budryn@p.lodz.pl;
   a.jurgonski@pan.olsztyn.pl; j.juskiewicz@pan.olsztyn.pl;
   z.zdunczyk@pan.olsztyn.pl
RI JUSKIEWICZ, Jerzy/H-7193-2017; Budryn, Grazyna/M-4168-2018; Oracz,
   Joanna/M-3099-2018; Zyzelewicz, Dorota/M-3397-2018; ZDUNCZYK,
   Zenon/H-7272-2017; JURGONSKI, Adam/A-5864-2009
OI JUSKIEWICZ, Jerzy/0000-0003-0068-5970; Budryn,
   Grazyna/0000-0002-8050-3702; Oracz, Joanna/0000-0003-2469-3369;
   Zyzelewicz, Dorota/0000-0003-0989-0671; ZDUNCZYK,
   Zenon/0000-0002-0640-7552; JURGONSKI, Adam/0000-0003-3524-3259
FU Polish National Center for Research and Development
   [WNP-POIG.02.01.00-10-171/09]
FX This research was funded by Polish National Center for Research and
   Development, grant number WNP-POIG.02.01.00-10-171/09.
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NR 73
TC 10
Z9 10
U1 0
U2 10
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD APR
PY 2020
VL 12
IS 4
AR 889
DI 10.3390/nu12040889
PG 17
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA LL8VE
UT WOS:000531831300009
PM 32218245
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Gomaa, AA
   Makboul, RM
   El-Mokhtar, MA
   Abdel-Rahman, EA
   Ahmed, IA
   Nicola, MA
AF Gomaa, Adel A.
   Makboul, Rania M.
   El-Mokhtar, Mohamed A.
   Abdel-Rahman, Engy A.
   Ahmed, Israa A.
   Nicola, Mariam A.
TI Terpenoid-rich Elettaria cardamomum extract prevents
   Alzheimer-like alterations induced in diabetic rats via inhibition of
   GSK3β activity, oxidative stress and pro-inflammatory cytokines
SO CYTOKINE
LA English
DT Article
DE AD-like alterations; Diabetic rats; Cardamom extract; Oxidative stress;
   Cytokines
ID EXPRESSION; MODEL; DISEASE; BRAIN; PCR
AB Purpose: Recent studies suggested that the non-familiar form of Alzheimer's disease (AD) could be consequence of metabolic syndrome and neuroinflammation. Elettaria cardamomum extract (EC) has exhibited antidiabetic, antioxidant and anti-inflammatory properties. This research was conducted to evaluate the effects of EC on AD like alterations in rats induced by high fructose and high fat diet coupled with a single small dose of STZ (25 mg/kg) (T2DM rats).
   Methods: Phytochemical analysis was carried out. Behavioral tests, immunohistochemical examination, biochemical analysis and gene expression determination were performed in treated and controls rats.
   Results: The majority of EC compounds were terpenoids. EC extract administration for 8 weeks attenuated AD like alterations. It reversed a T2DM-induced decline in cognitive functions in passive avoidance task and Morris water maze test. It significantly lowered the elevated hippocampal level of AChE activity and caspase-3 activity, an indicator of degeneration in T2DM rats Also, it reduced the accumulation of A beta and p-tau in the brain of T2DM rats. Furthermore, it elevated the suppressed glutamate receptor expression (AMPA GluR1 subunit and NMDA receptor subunits NR1, NR2A, NR2B). EC treatment reduced hippocampal lipid peroxidation marker malondialdehyde (MDA) and augmented antioxidant defensive system, including superoxide dismutase (SOD) and reduced glutathione (GSH). Meanwhile, it lowered hippocampal TNF alpha, IL beta 1but not IL6 and reduced GSK-3 beta in brainT2D rats.
   Conclusion: EC treatment could ameliorate AD-like alterations in T2DM rats through activation of blunted insulin signal transduction in the brain, attenuation of associated oxidative stress and neuroinflammation.
C1 [Gomaa, Adel A.; Abdel-Rahman, Engy A.; Ahmed, Israa A.; Nicola, Mariam A.] Assiut Univ, Dept Pharmacol, Fac Med, Assiut, Egypt.
   [Makboul, Rania M.] Assiut Univ, Dept Pathol, Fac Med, Assiut, Egypt.
   [El-Mokhtar, Mohamed A.] Assiut Univ, Dept Microbiol & Immun, Fac Med, Assiut, Egypt.
C3 Egyptian Knowledge Bank (EKB); Assiut University; Egyptian Knowledge
   Bank (EKB); Assiut University; Egyptian Knowledge Bank (EKB); Assiut
   University
RP Gomaa, AA (corresponding author), Assiut Univ, Dept Med Pharmacol, Fac Med, Assiut, Egypt.
EM a.gomma@aun.edu.eg
RI El-Mokhtar, Mohamed/AAP-4906-2020; Gomaa, Adel/E-7326-2010; El-Mokhtar,
   Mohamed A./HLQ-5588-2023
OI El-Mokhtar, Mohamed A./0000-0003-1943-8419; Gomaa,
   Adel/0000-0002-6462-0917
FU Scientific & The Technology Development Fund (STDF), (program), Ministry
   of State for Scientific Research, Egypt [6897]
FX This work was supported by The Scientific & The Technology Development
   Fund (STDF), (program), Ministry of State for Scientific Research, Egypt
   (Grant #6897) to purchase materials. We would like also, to acknowledge
   the Medical Research Center, Faculty of Medicine, Assiut University for
   providing the required equipment that are used in carrying out the
   molecular biology experiments. We thank Prof. Makboul Ahmed Makboul,
   professor of Pharmacognosy, Faculty of Pharmacy, Assiut University for
   his specialized assistance in authentication and extraction of the plant
   materials.
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NR 42
TC 34
Z9 35
U1 2
U2 17
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 1043-4666
EI 1096-0023
J9 CYTOKINE
JI Cytokine
PD JAN
PY 2019
VL 113
BP 405
EP 416
DI 10.1016/j.cyto.2018.10.017
PG 12
WC Biochemistry & Molecular Biology; Cell Biology; Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology; Immunology
GA HG1XF
UT WOS:000454753700049
PM 30539783
DA 2025-06-11
ER

PT J
AU Lee, E
   Choi, J
   Lee, HS
AF Lee, Eugene
   Choi, Jin
   Lee, Hyun Soon
TI Palmitate induces mitochondrial superoxide generation and activates AMPK
   in podocytes
SO JOURNAL OF CELLULAR PHYSIOLOGY
LA English
DT Article
DE CD36; diabetic nephropathy; free fatty acids; lipotoxicity; oxidative
   stress
ID CHRONIC KIDNEY-DISEASE; LONGEST-LIVING RODENT; CHAIN FATTY-ACIDS; NAKED
   MOLE-RAT; DIABETIC-NEPHROPATHY; HYDROGEN-PEROXIDE; OXIDATIVE STRESS;
   PROTEIN-KINASE; INSULIN-RESISTANCE; METABOLIC SYNDROME
AB Studies have shown that high levels of serum free fatty acids (FFAs) are associated with lipotoxicity and type 2 diabetes. Palmitic acid (PA) is the predominant circulating saturated FFA, yet its role in the pathogenesis of diabetic nephropathy (DN) is not clear. Recently, one study suggested that mitochondrial superoxide production is related to AMP-activated protein kinase (AMPK) activity in diabetic mice kidneys. To elucidate the link between PA and oxidative stress andAMPK activity in DN, we compared the cultured murine podocytes exposed to PA and oleic acid (OA). Incubation of cells with 250 mu M PA or OA induced a translocation of CD36, a fatty acid transport protein, with intracellular lipid accumulation. PA, but not OA, induced mitochondrial superoxide and hydrogen peroxide (H2O2) generation in podocytes, as shown by enhanced fluorescence of MitoSOX Red and dichlorofluorescein (DCF), respectively. Costimulation of PA-treated cells with the H2O2 scavenger catalase abolished the PA-induced DCF fluorescence. Only PA induced mitochondrial damage as shown by electron microscopy. The AMPK activity was determined by immunoblotting, measuring the ratio of phosphorylated AMPK (p-AMPK) to total AMPK. Only PA significantly increased the p-AMPK levels compared with controls. Addition of catalase to PA-treated cells did not affect the PA-stimulated p-AMPK levels. Collectively, our results indicate that PA induces mitochondrial superoxide and H2O2 generation in cultured podocytes, which may not be directly linked to AMPK activation. Given that, PA seems to play an important role in the pathogenesis of DNthrough lipotoxicity initiated by mitochondrial superoxide overproduction.
C1 [Lee, Eugene; Choi, Jin; Lee, Hyun Soon] Hankook Kidney & Diabet Inst, Renal Pathol Lab, Samhaksa Ro 93, Seoul 05602, South Korea.
RP Lee, HS (corresponding author), Hankook Kidney & Diabet Inst, Renal Pathol Lab, Samhaksa Ro 93, Seoul 05602, South Korea.
EM hyunsoon@plaza.snu.ac.kr
OI Lee, Hyun Soon/0000-0003-0682-3115
FU Hankook Kidney and Diabetes Institute [HRPL 1301]
FX Hankook Kidney and Diabetes Institute, Grant number: HRPL 1301
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NR 52
TC 49
Z9 52
U1 1
U2 77
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0021-9541
EI 1097-4652
J9 J CELL PHYSIOL
JI J. Cell. Physiol.
PD DEC
PY 2017
VL 232
IS 12
BP 3209
EP 3217
DI 10.1002/jcp.25867
PG 9
WC Cell Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Physiology
GA FE3ZV
UT WOS:000408155100001
PM 28214337
DA 2025-06-11
ER

PT J
AU Grummon, AH
   Vaughn, A
   Jones, DJ
   Ward, DS
AF Grummon, Anna H.
   Vaughn, Amber
   Jones, Deborah J.
   Ward, Dianne S.
TI Cumulative Risk Exposure and Waist Circumference in Preschool-Aged
   Children: the Mediating Role of Television and Moderating Role of Sex
SO ANNALS OF BEHAVIORAL MEDICINE
LA English
DT Article
DE Cumulative risk; Stressors; Family stress; Environmental factors;
   Childhood overweight; Childhood obesity; Body weight; Waist
   circumference; Television viewing; Mediation; Moderation; Sex
   differences
ID BODY-MASS INDEX; PHYSICAL-ACTIVITY; CHILDHOOD OBESITY; DIAGNOSTIC
   PERFORMANCE; METABOLIC SYNDROME; IDENTIFY OBESITY; STRESS; HEALTH;
   POVERTY; YOUTH
AB Children exposed to multiple stressors are more likely to be overweight, but little is known about the mechanisms explaining this association.
   This cross-sectional study examined whether children exposed to multiple stressors had higher waist circumference, and whether this association was mediated through children's television time.
   Participants were 319 parent-child dyads. Children were 2-5 years old and had at least one overweight parent (BMI ae<yen> 25 kg/m(2)). Data were collected at baseline of a larger childhood obesity prevention study and included information on psychosocial stressors (e.g., parenting stress), demographic stressors (e.g., low income), children's television time, and children's waist circumference. Two cumulative risk scores were created by summing stressors in each domain (demographic and psychosocial). Mediation and moderated mediation analyses were conducted.
   Indirect effects of both cumulative risk scores on waist circumference through television time were not significant; however, moderated mediation analyses found significant moderation by gender. The indirect effects of both risk scores on waist circumference through television time were significant and positive for girls, but near-zero for boys.
   Reducing television time should be explored as a strategy for buffering against the negative health effects of exposure to multiple stressors among girls. Longitudinal and intervention research is needed to confirm these results and to identify mediating factors between cumulative risk and body weight among boys.
C1 [Grummon, Anna H.] Univ North Carolina Chapel Hill, Gillings Sch Global Publ Hlth, Dept Hlth Behav, Chapel Hill, NC USA.
   [Vaughn, Amber; Ward, Dianne S.] Univ N Carolina, Ctr Hlth Promot & Dis Prevent, 135 Dauer Dr,2200 McGavran Greenberg Hall,CB 7461, Chapel Hill, NC 27599 USA.
   [Jones, Deborah J.] Univ N Carolina, Dept Psychol, Chapel Hill, NC USA.
   [Ward, Dianne S.] Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Nutr, 135 Dauer Dr,2200 McGavran Greenberg Hall,CB 7461, Chapel Hill, NC 27599 USA.
C3 University of North Carolina School of Medicine; University of North
   Carolina; University of North Carolina Chapel Hill; University of North
   Carolina; University of North Carolina Chapel Hill; University of North
   Carolina; University of North Carolina Chapel Hill; University of North
   Carolina; University of North Carolina Chapel Hill
RP Ward, DS (corresponding author), Univ N Carolina, Ctr Hlth Promot & Dis Prevent, 135 Dauer Dr,2200 McGavran Greenberg Hall,CB 7461, Chapel Hill, NC 27599 USA.; Ward, DS (corresponding author), Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Nutr, 135 Dauer Dr,2200 McGavran Greenberg Hall,CB 7461, Chapel Hill, NC 27599 USA.
EM dsward@email.unc.edu
OI Jones, Deborah/0000-0002-5168-9245; Grummon, Anna/0000-0002-8705-038X;
   Ward, Dianne Stanton/0000-0001-6389-0168
FU National Heart, Lung, and Blood Institute [R01 HL 091093]; Center for
   Health Promotion and Disease Prevention, a Prevention Research Center;
   Centers for Disease Control and Prevention [U48-DP005017]
FX This research was supported in part by a grant from the National Heart,
   Lung, and Blood Institute (R01 HL 091093). The project was conducted out
   of the Center for Health Promotion and Disease Prevention, a Prevention
   Research Center funded through a cooperative agreement with the Centers
   for Disease Control and Prevention (U48-DP005017). The findings and
   conclusions in this journal article are those of the authors and do not
   necessarily represent the official position of the Centers for Disease
   Control and Prevention.
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NR 66
TC 5
Z9 5
U1 1
U2 19
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0883-6612
EI 1532-4796
J9 ANN BEHAV MED
JI Ann. Behav. Med.
PD AUG
PY 2017
VL 51
IS 4
BP 489
EP 499
DI 10.1007/s12160-016-9872-y
PG 11
WC Psychology, Multidisciplinary
WE Social Science Citation Index (SSCI)
SC Psychology
GA FF1YF
UT WOS:000408694400002
PM 28097514
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Lin, PY
   Chen, CH
   Wallace, CG
   Chen, KH
   Chang, CL
   Chen, HH
   Sung, PH
   Lin, KC
   Ko, SF
   Sun, CK
   Chang, HW
   Shao, PL
   Lee, MS
   Yip, HK
AF Lin, Pao-Yuan
   Chen, Chih-Hung
   Wallace, Christopher Glenn
   Chen, Kuan-Hung
   Chang, Chia-Lo
   Chen, Hong-Hwa
   Sung, Pei-Hsun
   Lin, Kun-Chen
   Ko, Sheung-Fat
   Sun, Cheuk-Kwan
   Chang, Hsueh-Wen
   Shao, Pei-Lin
   Lee, Mel S.
   Yip, Hon-Kan
TI Therapeutic effect of rosuvastatin and propylthiouracil on ameliorating
   high-cholesterol diet-induced fatty liver disease, fibrosis and
   inflammation in rabbit
SO AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
LA English
DT Article
DE oxidative stress; inflammation; hypercholesterolemia; liver fibrosis;
   fatty liver
ID NONALCOHOLIC STEATOHEPATITIS; HEPATOCELLULAR-CARCINOMA; METABOLIC
   SYNDROME; UNITED-STATES; RISK-FACTORS; HYPERTENSION; SIMVASTATIN;
   STATINS; NAFLD; MICE
AB This study tested the hypothesis that high-cholesterol diet (HCD)-induced fatty liver disease could be ameliorated by rosuvastatin (Ros) and propylthiouracil (PTU) therapy. Thirty-two Zealand rabbits were equally divided into group 1 (sham-control), group 2 (HCD for 8 weeks), group 3 [HCD-Ros (20 mg/kg/day administration after 4-week HFD for 4 weeks)], group 4 [HCD-PTU (0.1% PTU in drinking water) with treatment course as group 3]. Liver weight, fibrosis, collagen deposition area, and serum levels of AST/ALT were highest in group 2, lowest in group 1, and significantly higher in group 4 than group 3 (all p<0.0001). The levels of inflammatory (TNF-alpha/NF-kappa B/IL-1 beta/IL-6/MMP-9/VCAM-1/PAI-1/TLR-4, MyD88/IL-12/IFN-gamma), oxidative stress (NOX-1/NOX-2/oxidized protein), apoptotic (Bax/cleaved-capase-3/PARP), fibrotic (Smad-3/TGF-beta), and mitochondria-damaged (cytosolic-cytochrome-C) proteins showed an identical pattern, whereas antiapoptotic (Bcl-2), mitochondrial-integrity (mitochondrial-cytochromeC) and antioxidative (SIRT1/SIRT3) biomarkers exhibited an opposite pattern to fibrosis among the four groups (all p<0.0001). The cellular expressions of inflammatory (Kupffer/CD14/CD44), alpha-fetoprotein-positively stained biomarkers, apoptotic nuclei and fat cells displayed an identical pattern to fibrosis (all p<0.0001). In conclusion, Ros-PTU therapy attenuated liver fibrosis, inflammatory reaction and generation of oxidative stress and fatty liver after HCD challenge in rabbits.
C1 [Lin, Pao-Yuan] Chang Gung Univ, Kaohsiung Chang Gung Mem Hosp, Coll Med, Dept Plast & Reconstruct Surg, Kaohsiung 83301, Taiwan.
   [Chen, Chih-Hung] Chang Gung Univ, Kaohsiung Chang Gung Mem Hosp, Coll Med, Div Gen Med,Dept Internal Med, Kaohsiung 83301, Taiwan.
   [Chen, Kuan-Hung; Lin, Kun-Chen] Chang Gung Univ, Kaohsiung Chang Gung Mem Hosp, Coll Med, Dept Anesthesiol, Kaohsiung 83301, Taiwan.
   [Chang, Chia-Lo; Chen, Hong-Hwa] Chang Gung Univ, Kaohsiung Chang Gung Mem Hosp, Coll Med, Div Colorectal Surg,Dept Surg, Kaohsiung 83301, Taiwan.
   [Sung, Pei-Hsun; Yip, Hon-Kan] Chang Gung Univ, Kaohsiung Chang Gung Mem Hosp, Coll Med, Div Cardiol,Dept Internal Med, Kaohsiung 83301, Taiwan.
   [Ko, Sheung-Fat] Chang Gung Univ, Kaohsiung Chang Gung Mem Hosp, Coll Med, Dept Radiol, Kaohsiung 83301, Taiwan.
   [Lee, Mel S.] Chang Gung Univ, Kaohsiung Chang Gung Mem Hosp, Coll Med, Dept Orthoped, Kaohsiung 83301, Taiwan.
   [Yip, Hon-Kan] Chang Gung Univ, Kaohsiung Chang Gung Mem Hosp, Coll Med, Inst Translat Res Biomed, Kaohsiung 83301, Taiwan.
   [Yip, Hon-Kan] Chang Gung Univ, Kaohsiung Chang Gung Mem Hosp, Coll Med, Ctr Shockwave Med, Kaohsiung 83301, Taiwan.
   [Yip, Hon-Kan] Chang Gung Univ, Kaohsiung Chang Gung Mem Hosp, Coll Med, Ctr Tissue Engn, Kaohsiung 83301, Taiwan.
   [Wallace, Christopher Glenn] Univ South Manchester Hosp, Dept Plast Surg, Manchester, Lancs, England.
   [Chang, Hsueh-Wen] I Shou Univ, E DA Hosp, Dept Emergency Med, Kaohsiung 82445, Taiwan.
   [Chang, Hsueh-Wen] Natl Sun Yat Sen Univ, Dept Biol Sci, Kaohsiung 80424, Taiwan.
   [Shao, Pei-Lin; Yip, Hon-Kan] Asia Univ, Dept Nursing, Taichung 41354, Taiwan.
   [Yip, Hon-Kan] China Med Univ, China Med Univ Hosp, Dept Med Res, Taichung 40402, Taiwan.
C3 Chang Gung Memorial Hospital; Chang Gung University; Chang Gung Memorial
   Hospital; Chang Gung University; Chang Gung Memorial Hospital; Chang
   Gung University; Chang Gung University; Chang Gung Memorial Hospital;
   Chang Gung Memorial Hospital; Chang Gung University; Chang Gung
   University; Chang Gung Memorial Hospital; Chang Gung University; Chang
   Gung Memorial Hospital; Chang Gung University; Chang Gung Memorial
   Hospital; Chang Gung University; Chang Gung Memorial Hospital; Chang
   Gung Memorial Hospital; Chang Gung University; Wythenshawe Hospital NHS
   Foundation Trust; I Shou University; E-Da Hospital; National Sun Yat Sen
   University; Asia University Taiwan; China Medical University Taiwan;
   China Medical University Hospital - Taiwan
RP Yip, HK (corresponding author), Kaohsiung Chang Gung Mem Hosp, Dept Internal Med, Div Cardiol, 123 Dapi Rd, Kaohsiung 83301, Taiwan.
EM han.gung@msa.hinet.net
RI Chen, Chien-Hung/AFU-7949-2022; Sun, Cheuk-Kwan/K-5723-2012; Chen,
   YuChun/L-1052-2019; Chen, Kuan-Hung/LIC-4398-2024
OI Sung, Pei-Hsun/0000-0002-1989-9752; Chen, Chih-Hung/0000-0003-3718-2373
FU Chang Gung Memorial Hospital, Chang Gung University [CMRPG8C0751,
   CMRPG8C0752]
FX This study was supported by a program grant from Chang Gung Memorial
   Hospital, Chang Gung University (Grant number: CMRPG8C0751 &
   CMRPG8C0752).
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NR 34
TC 6
Z9 6
U1 1
U2 4
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 1943-8141
J9 AM J TRANSL RES
JI Am. J. Transl. Res.
PY 2017
VL 9
IS 8
BP 3827
EP 3841
PG 15
WC Oncology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Research & Experimental Medicine
GA FF0VR
UT WOS:000408619700028
PM 28861173
DA 2025-06-11
ER

PT J
AU Bringhenti, I
   Ornellas, F
   Martins, MA
   Mandarim-de-Lacerda, CA
   Aguila, MB
AF Bringhenti, Isabele
   Ornellas, Fernanda
   Martins, Marcela Anjos
   Mandarim-de-Lacerda, Carlos Alberto
   Aguila, Marcia Barbosa
TI Early hepatic insult in the offspring of obese maternal mice
SO NUTRITION RESEARCH
LA English
DT Article
DE Metabolic programming; Hepatic steatosis; Oxidative stress; Lipogenesis;
   beta-Oxidation; Stereology; Mice
ID FATTY LIVER-DISEASE; OXIDATIVE STRESS; METABOLIC-SYNDROME; DIET;
   PREGNANCY; RESISTANCE; STEATOHEPATITIS; METHYLATION; HOMEOSTASIS;
   DYSFUNCTION
AB We hypothesized that the maternal obesity initiates metabolic disorders associated with oxidative stress in the liver of offspring since early life. Mouse's mothers were assigned into 2 groups according to the diet offered (n = 10 per group): standard chow (SC) or high-fat diet (HF). The results revealed that HP offspring had an increase in body mass at day 10 (+25%, P <.05) and in glucose levels (+25%, P <.0001). Hepatic triacylglycerol was increased in HF offspring at day 1 and day 10 compared with SC offspring (+30%, P <.01 and +40%, P <.01) as was hepatic steatosis (+110%, P <.001; +145%, P <.0001). Fatty acid synthase was increased in HF offspring at day 1 (+450%, P <.01) and peroxisome proliferator activator receptor-gamma was elevated at day 1 and day 10 (+140%, P <.01; +2741%, P <.01). Peroxisome proliferator activator receptor-a was diminished in HF offspring at day 10 compared with SC offspring (-100%, P <.01). Moreover, carnitine palmitoyl-CoA transferase-1 was decreased in HF offspring at day 1 and day 10 (-80%, P <.01; 60%, P <.05). In the HF offspring (compared with the SC offspring), the catalase and the superoxide dismutase were significantly lower in both days 1 and 10 (P <.05). In 10-day-old offspring, glutathione peroxidase 1 and glutathione reductase were lower in HF offspring than in SC offspring (P <.0001). Our findings suggest that the maternal obesity in mice induces an early oxidative dysfunction coupled with hepatic steatosis and might contribute to progressive liver injury later in life. (C) 2015 Elsevier Inc. All rights reserved.
C1 [Bringhenti, Isabele; Ornellas, Fernanda; Martins, Marcela Anjos; Mandarim-de-Lacerda, Carlos Alberto; Aguila, Marcia Barbosa] Univ Estado Rio De Janeiro, Lab Morphometry Metab & Cardiovasc Dis, Biomed Ctr, BR-20551030 Rio De Janeiro, RJ, Brazil.
C3 Universidade do Estado do Rio de Janeiro
RP Mandarim-de-Lacerda, CA (corresponding author), Univ Estado Rio De Janeiro, Lab Morphometry Metab & Cardiovasc Dis, Biomed Ctr, Av 28 Setembro 87 Fds, BR-20551030 Rio De Janeiro, RJ, Brazil.
RI MARTINS, MARCO/HJH-3671-2023; Aguila, Marcia/P-2349-2019;
   Mandarim-de-Lacerda, Carlos/P-2360-2019
OI Barbosa Aguila, Marcia/0000-0003-3994-4589; Mandarim-de-Lacerda,
   Carlos/0000-0003-4134-7978
FU National Council for Scientific Research (CNPq, Brazil); Rio de Janeiro
   Foundation for Research (Faperj); Coordination of Improvement of Higher
   Education Personnel (CAPES)
FX The research was supported by the National Council for Scientific
   Research (CNPq, Brazil), the Rio de Janeiro Foundation for Research
   (Faperj), and the Coordination of Improvement of Higher Education
   Personnel (CAPES). The funding sources had no role in study design; in
   the collection, analysis, and interpretation of data; in the writing of
   the report; and in the decision to submit the manuscript for
   publication.
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NR 44
TC 23
Z9 23
U1 0
U2 4
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0271-5317
EI 1879-0739
J9 NUTR RES
JI Nutr. Res.
PD FEB
PY 2015
VL 35
IS 2
BP 136
EP 145
DI 10.1016/j.nutres.2014.11.006
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA CB9EE
UT WOS:000349934000006
PM 25582085
OA hybrid
DA 2025-06-11
ER

PT J
AU Ordoñez, R
   Carbajo-Pescador, S
   Mauriz, JL
   González-Gallego, J
AF Ordonez, R.
   Carbajo-Pescador, S.
   Mauriz, J. L.
   Gonzalez-Gallego, J.
TI Understanding Nutritional Interventions and Physical Exercise in
   Non-Alcoholic Fatty Liver Disease
SO CURRENT MOLECULAR MEDICINE
LA English
DT Article
DE Exercise; fat; liver; NAFLD; nutritional intervention; steatosis
ID ACTIVATED PROTEIN-KINASE; ACETYL-COA CARBOXYLASE; ACID-BINDING PROTEIN;
   IMPROVES HEPATIC STEATOSIS; NECROSIS-FACTOR-ALPHA; KAPPA-B ACTIVATION;
   X-RECEPTOR LXR; INSULIN-RESISTANCE; OXIDATIVE STRESS; LIPID-ACCUMULATION
AB Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease in adults and its prevalence is rising around the world. This pathology is characterized by accumulation of liver fat, which exceeds 5% of liver weight in absence of alcohol consumption, viral infection or other hepatic etiology. Since NAFLD has been associated with obesity, insulin resistance, diabetes or alteration of lipid profiles, it is considered as the liver manifestation of metabolic syndrome. Pathogenic mechanisms of NAFLD have not been clearly elucidated, but different events such as lipid accumulation, insulin resistance, oxidative and endoplasmic reticulum stress, mitochondrial dysfunction and inflammation are involved. Modifications in lifestyle constitute the first line for the management of NAFLD. Nutritional interventions include low fat and carbohydrate diet with higher polyunsaturated fatty acids ingestion. Moreover, supplementation with antioxidant and cytoprotective agents could be useful to decrease oxidative stress, inflammation and fibrosis. Physical activity enables to reduce the expression of lipogenic genes, fat accumulation, or insulin resistance and improves cardiorespiratory fitness. Benefits have been found following both aerobic exercise and resistance training, and remain even after exercise cessation. However, more studies are required to analyze the molecular and cellular mechanisms involved in nutritional and physical intervention, and to define the volume of activity required and its association with weight loss. In this paper, we offer an updated overview of the mechanisms implicated in the progression of NAFLD, and analyze the beneficial effects of nutritional interventions and physical exercise in the prevention and treatment of this condition.
C1 [Ordonez, R.; Mauriz, J. L.; Gonzalez-Gallego, J.] Univ Leon, Ctr Invest Biomed Red Enfermedades Hepat & Digest, E-24071 Leon, Spain.
   [Ordonez, R.; Mauriz, J. L.; Gonzalez-Gallego, J.] Univ Leon, Inst Biomed IBIOMED, E-24071 Leon, Spain.
   [Carbajo-Pescador, S.] Scripps Res Inst, Dept Cell & Mol Biol, La Jolla, CA 92037 USA.
C3 CIBER - Centro de Investigacion Biomedica en Red; CIBEREHD; Universidad
   de Leon; Universidad de Leon; Scripps Research Institute
RP González-Gallego, J (corresponding author), Inst Biomed IBIOMED, Campus Univ, Leon 24071, Spain.
EM jgonga@unileon.es
RI Gonzalez-Gallego, Javier/D-8219-2012; Ordóñez, Raquel/H-6367-2015;
   Mauriz, Jose L/G-9970-2014
OI Carbajo-Pescador, Sara/0000-0002-6751-4597; Gonzalez-Gallego,
   Javier/0000-0002-4386-9342; Mauriz, Jose L/0000-0003-3160-8599
FU program Formacion del Profesorado Universitario form the Ministry of
   Education (Spain); Instituto de Salud Carlos III, Spain
FX Raquel Ordonez is granted by the program Formacion del Profesorado
   Universitario form the Ministry of Education (Spain). CIBERehd is
   financed by the Instituto de Salud Carlos III, Spain.
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NR 250
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Z9 32
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SN 1566-5240
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J9 CURR MOL MED
JI Curr. Mol. Med.
PY 2015
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BP 3
EP 26
DI 10.2174/1566524015666150114110551
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GA AZ4SX
UT WOS:000348214400002
PM 25601465
DA 2025-06-11
ER

PT J
AU Petrofsky, JS
   Laymon, M
   Lee, H
   Yim, J
   Harnandez, E
   Dequine, D
   Thorsen, L
   Lovell, K
   Andrade, J
AF Petrofsky, Jerrold Scott
   Laymon, Michael
   Lee, Haneul
   Yim, Jong
   Harnandez, Erin
   Dequine, Donny
   Thorsen, Lindsay
   Lovell, Kennith
   Andrade, Joshua
TI CoQ10 and Endothelial Function in Asians from Korea compared to Asians
   born in the United States and US Born Caucasians
SO MEDICAL SCIENCE MONITOR
LA English
DT Article
DE Q10; thrifty gene; endothelial
ID SKIN BLOOD-FLOW; NITRIC-OXIDE; OXIDATIVE STRESS; COENZYME-Q10
   SUPPLEMENTATION; METABOLIC SYNDROME; VITAMIN-E; EXERCISE; HEAT; FAT;
   EXPRESSION
AB Background: The vascular endothelium is the interface between the blood and vascular smooth muscle in arteries. It is easily damaged by oxidative stress. Recent studies show that Asians are more susceptible than Caucasians to impairment of endothelial function. This study examined endothelial function in US-born Caucasians, Asians from Korea, and US-born Asians (almost all Korean decent) and examined the effect of coenzyme Q10 (CoQ10) on endothelial function.
   Material/Methods: Twenty Caucasians and 30 Asians participated (<35 years old, males and females). Endothelial function was assessed by the skin blood flow response to local heat using a thermode for 6 minutes at 44 degrees C and by vascular occlusion for 4 minutes followed by release and measurement of skin blood flow for 2 minutes. In the US-born subjects, the experiments were repeated after 2-week administration of CoQ10 or a placebo.
   Results: When applying 6 minutes of local heat at 44 degrees C, the skin blood flows were significantly higher in Caucasians than both Asian groups Asians. Likewise after vascular occlusion, the blood flow response was greater in Caucasians compared to Asians. Asians born in Asia had the lowest response of the 3 groups of subjects. Administering CoQ10 for 2 weeks eliminated much of the difference between the groups, whereas there was no difference with a placebo.
   Conclusions: These findings suggest that Asians either born in Asia or the US may have lower endothelial function than Caucasians. This may be explained, in part, by genetic variations causing increased oxidative stress from westernized diets in Asians. Co enzyme Q10 administration narrows the difference between the groups.
C1 [Petrofsky, Jerrold Scott; Laymon, Michael; Harnandez, Erin; Dequine, Donny; Thorsen, Lindsay; Lovell, Kennith; Andrade, Joshua] Azusa Pacific Univ, Dept Phys Therapy, Azusa, CA 91702 USA.
   [Petrofsky, Jerrold Scott; Lee, Haneul] Loma Linda Univ, Dept Phys Therapy, Loma Linda, CA 92350 USA.
   [Yim, Jong] Sahmyook Univ, Dept Phys Therapy, Seoul, South Korea.
C3 Azusa Pacific University; Loma Linda University; Sahmyook University
RP Petrofsky, JS (corresponding author), Azusa Pacific Univ, Dept Phys Therapy, Azusa, CA 91702 USA.
EM jpetrofsky@llu.edu
RI Yim, JongEun/AAE-2930-2020
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NR 55
TC 5
Z9 5
U1 0
U2 4
PU INT SCIENTIFIC INFORMATION, INC
PI MELVILLE
PA 150 BROADHOLLOW RD, STE 114, MELVILLE, NY 11747 USA
SN 1643-3750
J9 MED SCI MONITOR
JI Med. Sci. Monitor
PD MAY 6
PY 2013
VL 19
BP 339
EP 346
DI 10.12659/MSM.883902
PG 8
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 159PR
UT WOS:000320058400001
PM 23666274
OA Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Kaltsas, A
   Giannakas, T
   Stavropoulos, M
   Kratiras, Z
   Chrisofos, M
AF Kaltsas, Aris
   Giannakas, Timoleon
   Stavropoulos, Marios
   Kratiras, Zisis
   Chrisofos, Michael
TI Oxidative Stress in Benign Prostatic Hyperplasia: Mechanisms, Clinical
   Relevance and Therapeutic Perspectives
SO DISEASES
LA English
DT Review
DE benign prostatic hyperplasia; oxidative stress; inflammation; reactive
   oxygen species
ID URINARY-TRACT SYMPTOMS; ANTIINFLAMMATORY DRUG-USE;
   ESTROGEN-RECEPTOR-ALPHA; METABOLIC SYNDROME; CHRONIC INFLAMMATION;
   CELL-PROLIFERATION; SCIENTIFIC BASIS; STROMAL CELLS; CANCER; EXPRESSION
AB Background/Objectives: Benign prostatic hyperplasia (BPH) is among the most common conditions affecting men as they age, resulting in lower urinary tract symptoms (LUTS) that can profoundly impact quality of life. While historically attributed primarily to androgenic imbalances, current evidence implicates additional factors-particularly oxidative stress (OS) and chronic inflammation-in BPH pathogenesis. This review aims to synthesize research on the interplay between OS, inflammation, and hormonal regulation in BPH, emphasizing their clinical relevance and potential therapeutic implications. Methods: A comprehensive review of peer-reviewed literature was conducted focusing on mechanistic studies, clinical trials, and observational reports. Searches included data on ROS generation, antioxidant capacity, inflammatory mediators, and their contribution to pathological prostatic overgrowth. Potential interventions targeting OS-such as antioxidant supplementation, anti-inflammatory drugs, vitamin D receptor agonists, and phytotherapeutics-were also evaluated for their efficacy and safety profiles. Results: Chronic inflammation and OS were consistently identified within hyperplastic prostate tissue. Excessive ROS production, diminished antioxidant defense, and sustained cytokine release create a proproliferative and antiapoptotic environment, accelerating disease progression. Metabolic comorbidities (e.g., obesity, insulin resistance) further exacerbate these imbalances. Standard therapies (alpha-blockers and 5-ARIs) effectively relieve symptoms but do not directly address the oxidative-inflammatory axis. Emerging evidence suggests that pharmacological and dietary approaches targeting OS and inflammation may reduce prostate volume expansion and alleviate LUTS. Conclusions: Findings indicate that OS and inflammation are key contributors to BPH progression. Incorporating antioxidant and anti-inflammatory strategies alongside conventional treatments holds promise for improving clinical outcomes and patient quality of life. Future research should focus on validating OS-specific biomarkers and optimizing personalized therapy regimens.
C1 [Kaltsas, Aris; Giannakas, Timoleon; Stavropoulos, Marios; Kratiras, Zisis; Chrisofos, Michael] Natl & Kapodistrian Univ Athens, Attikon Univ Hosp, Sch Med, Dept Urol 3, Athens 12462, Greece.
C3 National & Kapodistrian University of Athens; University Hospital
   Attikon; Athens Medical School
RP Chrisofos, M (corresponding author), Natl & Kapodistrian Univ Athens, Attikon Univ Hosp, Sch Med, Dept Urol 3, Athens 12462, Greece.
EM ares-kaltsas@hotmail.com; tgiannakas@gmail.com; stamarios@yahoo.gr;
   zkratiras@gmail.com; mxchris@yahoo.com
RI Kratiras, Zisis/IUP-1974-2023; Chrisofos, Michael/AAD-7138-2019
OI Kaltsas, Aris/0000-0003-4651-312X
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NR 125
TC 0
Z9 0
U1 4
U2 4
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2079-9721
J9 DISEASES-BASEL
JI Diseases
PD FEB
PY 2025
VL 13
IS 2
AR 53
DI 10.3390/diseases13020053
PG 19
WC Medicine, Research & Experimental
WE Emerging Sources Citation Index (ESCI)
SC Research & Experimental Medicine
GA Y6J1Q
UT WOS:001433152400001
PM 39997060
OA gold
DA 2025-06-11
ER

PT J
AU Mthiyane, FT
   Dludla, PV
   Ziqubu, K
   Mthembu, SXH
   Muvhulawa, N
   Hlengwa, N
   Nkambule, BB
   Mazibuko-Mbeje, SE
AF Mthiyane, Fikile T. T.
   Dludla, Phiwayinkosi V. V.
   Ziqubu, Khanyisani
   Mthembu, Sinenhlanhla X. H.
   Muvhulawa, Ndivhuwo
   Hlengwa, Nokulunga
   Nkambule, Bongani B. B.
   Mazibuko-Mbeje, Sithandiwe E. E.
TI A Review on the Antidiabetic Properties of Moringa oleifera
   Extracts: Focusing on Oxidative Stress and Inflammation as Main
   Therapeutic Targets
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Review
DE diabetes complications; oxidatie stress; inflammation; moringa (Moringa
   oleifera); therapeutic targets
ID MOLECULAR-MECHANISMS; LIPID-PEROXIDATION; INSULIN-RESISTANCE; METABOLIC
   SYNDROME; METFORMIN; LEAVES; ANTIOXIDANTS; NRF2; LEAF; TOXICITY
AB Moringa oleifera is one of the popular plants that have shown significant health benefits. Certainly, preclinical evidence (predominantly from animal models) summarized in the current review supports the beneficial effects of Moringa oleifera leaf extracts in combating the prominent characteristic features of diabetes mellitus. This includes effective control of blood glucose or insulin levels, enhancement of insulin tissue sensitivity, improvement of blood lipid profiles, and protecting against organ damage under sustained conditions of hyperglycemia. Interestingly, as major complications implicated in the progression of diabetes, including organ damage, Moringa oleifera leaf and seed extracts could efficiently block the detrimental effects of oxidative stress and inflammation in these preclinical models. Notably, these extracts (especially leaf extracts) showed enhanced effects in strengthening intracellular antioxidant defences like catalase, superoxide dismutase, and glutathione to lower lipid peroxidation products and reduce prominent pro-inflammatory markers such as tumor necrosis factor-alpha, interleukin (1L)-beta, IL-6, monocyte chemoattractant protein-1 and nitric oxide synthase. From animal models of diabetes, the common and effective dose of leaf extracts of Moringa oleifera was 100-300 mg/kg, within the treatment duration of 2-8 weeks. Whereas supplementation with approximately 20 g leaf powder of Moringa oleifera for at least 2 weeks could improve postprandial blood glucose in subjects with prediabetes or diabetes. Although limited clinical studies have been conducted on the antidiabetic properties of Moringa oleifera, current findings provide an important platform for future research directed at developing this plant as a functional food to manage diabetic complications.
C1 [Mthiyane, Fikile T. T.; Ziqubu, Khanyisani; Mthembu, Sinenhlanhla X. H.; Muvhulawa, Ndivhuwo; Mazibuko-Mbeje, Sithandiwe E. E.] North West Univ, Dept Biochem, Mafikeng, South Africa.
   [Dludla, Phiwayinkosi V. V.; Mthembu, Sinenhlanhla X. H.] South African Med Res Council, Biomed Res & Innovat Platform, Cape Town, South Africa.
   [Hlengwa, Nokulunga] Univ Zululand, Dept Biochem & Microbiol, Kwa Dlangezwa, South Africa.
   [Nkambule, Bongani B. B.] Univ KwaZulu Natal, Sch Lab Med & Med Sci, Durban, South Africa.
C3 North West University - South Africa; South African Medical Research
   Council; University of Zululand; University of Kwazulu Natal
RP Mazibuko-Mbeje, SE (corresponding author), North West Univ, Dept Biochem, Mafikeng, South Africa.
EM 36588296@nwu.ac.za
RI Nkambule, Bongani/ABD-7943-2022; Mazibuko-Mbeje,
   Sithandiwe/HPG-1119-2023
OI Hlengwa, Nokulunga/0000-0002-4658-1619; muvhulawa,
   ndivhuwo/0000-0003-2797-9717; Nkambule, Bongani/0000-0001-8846-1992;
   MTHEMBU, SINENHLANHLA/0000-0003-2747-1841
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NR 153
TC 33
Z9 34
U1 3
U2 16
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD JUL 11
PY 2022
VL 13
AR 940572
DI 10.3389/fphar.2022.940572
PG 17
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 6H9QX
UT WOS:000885766100001
PM 35899107
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Schaffert, A
   Karkossa, I
   Ueberham, E
   Schlichting, R
   Walter, K
   Arnold, J
   Blüher, M
   Heiker, JT
   Lehmann, J
   Wabitsch, M
   Escher, BI
   von Bergen, M
   Schubert, K
AF Schaffert, Alexandra
   Karkossa, Isabel
   Ueberham, Elke
   Schlichting, Rita
   Walter, Katharina
   Arnold, Josi
   Blueher, Matthias
   Heiker, John T.
   Lehmann, Joerg
   Wabitsch, Martin
   Escher, Beate I.
   von Bergen, Martin
   Schubert, Kristin
TI Di-(2-ethylhexyl) phthalate substitutes accelerate human adipogenesis
   through PPARγ activation and cause oxidative stress and impaired
   metabolic homeostasis in mature adipocytes
SO ENVIRONMENT INTERNATIONAL
LA English
DT Article
DE Peroxisome proliferator-activated receptor ?; (PPAR?); Plasticizers;
   Endocrine disruption; Oxidative stress; SGBS; Proteomics
ID ADIPOSE-TISSUE; ENDOCRINE DISRUPTORS; INSULIN-RESISTANCE; SGBS CELLS;
   OBESITY; IMPACT; DIFFERENTIATION; BIOMARKERS; FIBROSIS; UNIQUE
AB The obesity pandemic is presumed to be accelerated by endocrine disruptors such as phthalate-plasticizers, which interfere with adipose tissue function. With the restriction of the plasticizer di-(2-ethylhexyl)-phthalate (DEHP), the search for safe substitutes gained importance. Focusing on the master regulator of adipogenesis and adipose tissue functionality, the peroxisome proliferator-activated receptor gamma (PPAR gamma), we evaluated 20 alternative plasticizers as well as their metabolites for binding to and activation of PPAR gamma and assessed effects on adipocyte lipid accumulation. Among several compounds that showed interaction with PPAR gamma, the metabolites MINCH, MHINP, and OH-MPHP of the plasticizers DINCH, DINP, and DPHP exerted the highest adipogenic potential in human adipocytes. These metabolites and their parent plasticizers were further analyzed in human preadipocytes and mature adipocytes using cellular assays and global proteomics. In preadipocytes, the plasticizer metabolites significantly increased lipid accumulation, enhanced leptin and adipsin secretion, and upregulated adipogenesis-associated markers and pathways, in a similar pattern to the PPAR gamma agonist rosiglitazone. Proteomics of mature adipocytes revealed that both, the plasticizers and their metabolites, induced oxidative stress, disturbed lipid storage, impaired metabolic homeostasis, and led to proinflammatory and insulin resistance promoting adipokine secretion. In conclusion, the plasticizer metabolites enhanced preadipocyte differentiation, at least partly mediated by PPAR gamma activation and, together with their parent plasticizers, affected the functionality of mature adipocytes similar to reported effects of a high-fat diet. This highlights the need to further investigate the currently used plasticizer alternatives for potential associations with obesity and the metabolic syndrome.
C1 [Schaffert, Alexandra; Karkossa, Isabel; Walter, Katharina; Arnold, Josi; von Bergen, Martin; Schubert, Kristin] UFZ, Helmholtz Ctr Environm Res, Dept Mol Syst Biol, Leipzig, Germany.
   [Ueberham, Elke] Fraunhofer Inst Cell Therapy & Immunol, Dept GMP Proc Dev ATMP Design, Leipzig, Germany.
   [Schlichting, Rita; Escher, Beate I.] UFZ, Helmholtz Ctr Environm Res, Dept Cell Toxicol, Leipzig, Germany.
   [Blueher, Matthias; Heiker, John T.] Helmholtz Inst Metab, Obes & Vasc Res HI MAG, Leipzig, Germany.
   [Blueher, Matthias] Univ Leipzig, Fac Med, Dept Endocrinol Nephrol & Rheumatol, Leipzig, Germany.
   [Lehmann, Joerg] Fraunhofer Inst Cell Therapy & Immunol, Dept Preclin Dev & Validat, Leipzig, Germany.
   [Lehmann, Joerg] Fraunhofer Inst Cell Therapy & Immunol, Fraunhofer Cluster Excellence Immune Mediated Dis, Leipzig, Germany.
   [Wabitsch, Martin] Ulm Univ Med Ctr, Div Pediat Endocrinol & Diabet, Ulm, Germany.
   [Escher, Beate I.] Eberhard Karls Univ Tubingen, Ctr Appl Geosci, Environm Toxicol, Tubingen, Germany.
   [von Bergen, Martin] Univ Leipzig, Inst Biochem, Leipzig, Germany.
   [von Bergen, Martin] Ctr Integrat Biodivers Res iDiv Halle Jena Leipzi, Leipzig, Germany.
   [Schubert, Kristin] Helmholtz Ctr Environm Res, Dept Mol Syst Biol, Permoserstr 15, D-04318 Leipzig, Germany.
C3 Helmholtz Association; Helmholtz Center for Environmental Research
   (UFZ); Fraunhofer Gesellschaft; Fraunhofer Germany; Fraunhofer Cell
   Therapy & Immunology; Helmholtz Association; Helmholtz Center for
   Environmental Research (UFZ); Leipzig University; Fraunhofer
   Gesellschaft; Fraunhofer Germany; Fraunhofer Cell Therapy & Immunology;
   Fraunhofer Gesellschaft; Fraunhofer Germany; Fraunhofer Cell Therapy &
   Immunology; Ulm University; Eberhard Karls University of Tubingen;
   Leipzig University; German Research Foundation (DFG); German Centre for
   Integrative Biodiversity Research (iDiv); Helmholtz Association;
   Helmholtz Center for Environmental Research (UFZ)
RP Schubert, K (corresponding author), Helmholtz Ctr Environm Res, Dept Mol Syst Biol, Permoserstr 15, D-04318 Leipzig, Germany.
EM kristin.schubert@ufz.de
RI Schubert, Kristin/AAB-6438-2020; Escher, Beate/ABE-8070-2020; Heiker,
   John/O-9728-2019; Schlichting, Rita/JRX-4227-2023; Karkossa,
   Isabel/AAH-1809-2021; von Bergen, Martin/D-7960-2011
OI Heiker, John/0000-0003-2822-3006; Schaffert,
   Alexandra/0000-0001-8159-1292; von Bergen, Martin/0000-0003-2732-2977
FU German Federal Environmental Foundation (DBU) [SFB 1052/3]; UFZ; German
   Research Foundation (DFG) [SFB 1052/3]; State of Saxony; State of
   Saxony- Anhalt; Helmholtz Association
FX This research was funded by the German Federal Environmental Foundation
   (DBU) as a personal fellowship of Alexandra Schaffert. Furthermore, we
   are grateful for support by the UFZ-funded platform ProMetheus for
   proteome and metabolome analysis. Matthias Blueher, John T. Heiker,
   Martin von Bergen, Katharina Walter, and Josi Arnold are thankful for
   funding by the German Research Foundation (DFG) for the Clinical
   Research Center "Obesity Mechanisms" SFB 1052/3 (B1, C7, Z3). The
   reporter gene experiments were performed using the platform CITEPro
   (Chemicals in the Environment Profiler) funded by the Helmholtz
   Association with co-funding by the States of Saxony and Saxony- Anhalt
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NR 102
TC 47
Z9 51
U1 11
U2 56
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0160-4120
EI 1873-6750
J9 ENVIRON INT
JI Environ. Int.
PD JUN
PY 2022
VL 164
AR 107279
DI 10.1016/j.envint.2022.107279
EA MAY 2022
PG 17
WC Environmental Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology
GA 1V8XA
UT WOS:000806367700010
PM 35567983
OA gold
DA 2025-06-11
ER

PT J
AU Ortiz-Morales, AM
   Alcala-Diaz, JF
   Rangel-Zuñiga, OA
   Corina, A
   Quintana-Navarro, G
   Cardelo, MP
   Yubero-Serrano, E
   Malagon, MM
   Delgado-Lista, J
   Ordovas, JM
   Lopez-Miranda, J
   Perez-Martinez, P
AF Ortiz-Morales, Ana M.
   Alcala-Diaz, Juan F.
   Rangel-Zuniga, Oriol A.
   Corina, Andreea
   Quintana-Navarro, Gracia
   Cardelo, Magdalena P.
   Yubero-Serrano, Elena
   Malagon, Maria M.
   Delgado-Lista, Javier
   Ordovas, Jose M.
   Lopez-Miranda, Jose
   Perez-Martinez, Pablo
TI Biological senescence risk score. A practical tool to predict biological
   senescence status
SO EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
LA English
DT Article
DE ageing; cardiovascular disease; CORDIOPREV study; predictive models
ID LEUKOCYTE TELOMERE LENGTH; CORONARY-HEART-DISEASE; METABOLIC SYNDROME;
   CARDIOVASCULAR-DISEASE; MEDITERRANEAN DIET; OXIDATIVE STRESS;
   ASSOCIATION; PREVENTION; CORDIOPREV; BIOMARKER
AB Background Ageing and biological senescence, both related to cardiovascular disease, are mediated by oxidative stress and inflammation. We aim to develop a predictive tool to evaluate the degree of biological senescence in coronary patients.
   Methods Relative telomere length (RTL) of 1002 coronary patients from the CORDIOPREV study (NCT00924937) was determined at baseline in addition to markers of inflammatory response (hs-C-Reactive Protein, monocyte chemoattractant protein-1, IL-6, IL-1 beta, TNF-alpha, adiponectin, resistin and leptin) and oxidative stress (nitric oxide, lipid peroxidation products, carbonylated proteins, catalase, total glutathione, reduced glutathione, oxidized glutathione, superoxide dismutase and peroxidated glutathione). Biological senescence was defined using the cut-off value defined by the lower quintile of relative telomere length in our population (RTL = 0.7629). We generated and tested different predictive models based on logistic regression analysis to identify biological senescence. Three models were designed to be used with different sets of information.
   Results We selected those patients with all the variables proposed to develop the predictive models (n = 353). Statistically significant differences between both groups (Biological senescence vs. Nonbiological senescence) were found for total cholesterol, catalase, superoxide dismutase, IL-1 beta, resistin and leptin. The area under the curve of receiver-operating characteristic to predict biological senescence for our models was 0.65, 0.75 and 0.72.
   Conclusions These predictive models allow us to calculate the degree of biological senescence in coronary patients, identifying a subgroup of patients at higher risk and who may require more intensive treatment.
C1 [Ortiz-Morales, Ana M.; Alcala-Diaz, Juan F.; Rangel-Zuniga, Oriol A.; Corina, Andreea; Quintana-Navarro, Gracia; Cardelo, Magdalena P.; Yubero-Serrano, Elena; Delgado-Lista, Javier; Lopez-Miranda, Jose; Perez-Martinez, Pablo] Univ Cordoba, Dept Med, Lipids & Atherosclerosis Unit, IMIBIC,Hosp Univ Reina Sofia, Cordoba, Spain.
   [Ortiz-Morales, Ana M.; Alcala-Diaz, Juan F.; Rangel-Zuniga, Oriol A.; Corina, Andreea; Quintana-Navarro, Gracia; Cardelo, Magdalena P.; Yubero-Serrano, Elena; Malagon, Maria M.; Delgado-Lista, Javier; Lopez-Miranda, Jose; Perez-Martinez, Pablo] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr CIBEROBN, Madrid, Spain.
   [Malagon, Maria M.] Univ Cordoba, Dept Cell Biol Physiol & Immunol, Cordoba, Spain.
   [Ordovas, Jose M.] Tufts Univ, JM Us Dept Agr, Nutr & Genom Lab, Human Nutr Res Ctr Aging, Boston, MA 02111 USA.
   [Ordovas, Jose M.] IMDEA Alimentac, Madrid, Spain.
   [Ordovas, Jose M.] CNIC, Madrid, Spain.
C3 Universidad de Cordoba; CIBER - Centro de Investigacion Biomedica en
   Red; CIBEROBN; Instituto de Salud Carlos III; Universidad de Cordoba;
   Tufts University; United States Department of Agriculture (USDA); Centro
   Nacional de Investigaciones Cardiovasculares (CNIC)
RP Perez-Martinez, P (corresponding author), Reina Sofia Univ Hosp, Lipids & Atherosclerosis Res Unit, Avda Menendez Pidal S-N, Cordoba 14004, Spain.
EM pabloperez@uco.es
RI Lopez-Miranda, Jose/Y-8306-2019; YUBERO, ELENA/AFM-2738-2022;
   Delgado-Lista, Javier/KAM-7412-2024; Pc, Maleni/Y-9987-2019;
   Alcala-Diaz, Juan/F-5329-2016; Perez Martinez, Pablo/AEL-6176-2022;
   MALAGON, MARIA M/L-5386-2014
OI Alcala-Diaz, Juan Francisco/0000-0002-4572-3611; QUINTANA-NAVARRO,
   GRACIA MARIA/0000-0003-4413-4062; Yubero-Serrano, Elena
   M/0000-0002-2733-5359; Perez Martinez, Pablo/0000-0001-7716-8117;
   Delgado Lista, Francisco Javier/0000-0002-2982-2716; Rangel-Zuniga,
   Oriol Alberto/0000-0003-3495-5705; Perez Cardelo,
   Magdalena/0000-0002-3541-2190; Ortiz-Morales, Ana
   M./0000-0002-5729-0104; MALAGON, MARIA M/0000-0002-2419-2727;
   Lopez-Miranda, Jose/0000-0002-8844-0718
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NR 42
TC 5
Z9 5
U1 0
U2 16
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0014-2972
EI 1365-2362
J9 EUR J CLIN INVEST
JI Eur. J. Clin. Invest.
PD NOV
PY 2020
VL 50
IS 11
AR e13305
DI 10.1111/eci.13305
PG 9
WC Medicine, General & Internal; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Research & Experimental Medicine
GA ON1XF
UT WOS:000586502200023
PM 32506428
DA 2025-06-11
ER

PT J
AU Baykara, S
   Bozdag, PG
   Baykara, M
   Namli, MN
AF Baykara, Sema
   Bozdag, Pinar Gundogan
   Baykara, Murat
   Namli, Mustafa Nuray
TI Evaluation of arterial stiffness in patients with schizophrenia
SO JOURNAL OF CLINICAL NEUROSCIENCE
LA English
DT Article
DE Vascular stiffness; Schizophrenia; Antipsychotic agents
ID DRUG-NAIVE PATIENTS; METABOLIC SYNDROME; RISK-FACTORS; ATYPICAL
   ANTIPSYCHOTICS; MEDICAL-CARE; CORONARY; CALCIFICATION; METAANALYSIS;
   1ST-EPISODE; HEART
AB The aim of this study was to evaluate arterial stiffness in schizophrenia patients. 28 male patients were included. The intima-media thickness (IMT) of the vessels were taken using high-resolution ultrasonography system. The mean carotid IMT and the mean femoral IMT values of the study group were found to be statistically significantly higher than the values of the control group. As the duration of the disease increased, there was an increase in the carotid IMT, carotid elastic modulus and femoral IMT, whereas there was a decrease in carotid and femoral diastolic wall stress in patients. No statistically significant differences were observed between the groups' carotid and femoral compliance, distensibility and elastic modulus values. The mean systolic arterial blood pressure in the patient group was determined to be lower than that of the control group. The mean diastolic wall stress values in the carotid and femoral arteries were determined to be lower than those of the control group. There was no relationship between antipsychotic dose, blood pressure and arterial stiffness parameters. Schizophrenia patients are more prone to develop arterial stiffness by atherosclerosis either with the effect of the nature of the disease itself or antipsychotic treatment. But evaluation with more parameters (carotid and femoral compliance, distensibility and elastic modulus) did not indicate any difference from the control group in respect of arterial stiffness. Antipsychotic treatment may play a protective role in terms of arterial stiffness by causing a decrease in systolic arterial pressure and carotid and femoral diastolic wall stress. (C) 2020 Elsevier Ltd. All rights reserved.
C1 [Baykara, Sema] Firat Univ, Fac Med, Dept Psychiat, Elazig, Turkey.
   [Bozdag, Pinar Gundogan] Elazig Fethi Sekin City Hosp, Elazig, Turkey.
   [Baykara, Murat] Firat Univ, Fac Med, Dept Radiol, Elazig, Turkey.
   [Namli, Mustafa Nuray] Mental Hlth Hosp, Elazig, Turkey.
C3 Firat University; Firat University; Elazig Mental Health & Diseases
   Hospital
RP Baykara, S (corresponding author), Firat Univ, Fac Med, Dept Psychiat, Elazig, Turkey.
EM sbaykara@firat.edu.tr
RI Namlı, Mustafa/AAP-7758-2021; Baykara, Sema/W-1080-2018; Baykara,
   Murat/V-9081-2018; Gundogan Bozdag, Pinar/ADW-0920-2022
OI Baykara, Murat/0000-0003-2588-9013; Gundogan Bozdag,
   Pinar/0000-0002-7303-5832; namli, mustafa nuray/0000-0001-9778-4216
CR AlGhatrif M, 2013, HYPERTENSION, V62, P934, DOI 10.1161/HYPERTENSIONAHA.113.01445
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NR 32
TC 9
Z9 9
U1 0
U2 6
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0967-5868
EI 1532-2653
J9 J CLIN NEUROSCI
JI J. Clin. Neurosci.
PD SEP
PY 2020
VL 79
BP 149
EP 153
DI 10.1016/j.jocn.2020.07.008
PG 5
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology
GA OG5ML
UT WOS:000581927800030
PM 33070886
DA 2025-06-11
ER

PT J
AU Sola, E
   Vayá, A
   Martínez, M
   Moscardó, A
   Corella, D
   Santaolaria, ML
   España, F
   Hernández-Mijares, A
AF Sola, Eva
   Vaya, Amparo
   Martinez, Marcial
   Moscardo, Antonio
   Corella, Dolores
   Santaolaria, Maria-Luisa
   Espana, Francisco
   Hernandez-Mijares, Antonio
TI Erythrocyte Membrane Phosphatidylserine Exposure in Obesity
SO OBESITY
LA English
DT Article
ID CARDIOVASCULAR RISK-FACTORS; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   WEIGHT-LOSS; HEMORHEOLOGICAL ASPECTS; PHOSPHOLIPID ASYMMETRY;
   LIPID-PEROXIDATION; OXIDATIVE STRESS; PLASMA VISCOSITY; BLOOD RHEOLOGY
AB It has been suggested that increased erythrocyte membrane phosphatidylserine (PS) exposure could contribute to hypercoagulability and hemorheological disturbances in obesity. The aim of our study was to evaluate PS exposure in obese patients and in a control group and to correlate this with hemorheological properties, i.e., erythrocyte aggregability (EA) and deformability, and to evaluate the effect of weight loss on these parameters. An anthropometric and analytical evaluation was performed at baseline and after 3 months on a diet (very low-calorie diet for 4 weeks and low-calorie diet for 2 months) on 49 severe or morbid obese patients (37 women, 12 men) and 55 healthy volunteers (39 women, 16 men). PS exposure on erythrocyte membrane was performed by flow cytometry. Erythrocyte aggregation was measured using the Myrenne MA 1 and the Sefam aggregometer. Erythrocyte deformability was determined in a stress diffractometer. Prothrombin fragment F1+2 (F1+2) was determined as a marker of the hypercoagulable state, and plasma malondialdehyde (MDA) as an indicator of oxidative stress. Obese patients had a higher EA index, higher PS exposure on erythrocyte membranes and higher levels of MDA and F1+2. The differences in erythrocyte aggregation and F1+2 between obese patients and the control group were maintained after adjusting for PS exposure. After 3 months of diet, a significant reduction in PS exposure on erythrocyte membrane was observed. Obese patients show increased PS exposure on erythrocyte membrane, with no effect on rheological properties. Increased PS exposure could contribute to hypercoagulability in these patients. Weight loss obtained with diet treatment reduces PS exposure on erythrocyte membrane.
C1 [Sola, Eva; Hernandez-Mijares, Antonio] Doctor Peset Univ Hosp, Serv Endocrinol, Valencia, Spain.
   [Sola, Eva; Hernandez-Mijares, Antonio] Univ Valencia, Sch Med, Dept Med, Valencia, Spain.
   [Vaya, Amparo; Martinez, Marcial; Santaolaria, Maria-Luisa] La Fe Univ Hosp, Dept Clin Pathol, Hemorheol & Thrombosis Unit, Valencia, Spain.
   [Moscardo, Antonio; Espana, Francisco] La Fe Univ Hosp, Res Ctr, Valencia, Spain.
   [Corella, Dolores] Univ Valencia, Sch Med, Dept Prevent Med, Valencia, Spain.
   [Corella, Dolores] Univ Valencia, Sch Med, CIBER Fisiopatol Obesidad & Nutr, Valencia, Spain.
C3 University of Valencia; University of Valencia; University of Valencia;
   CIBER - Centro de Investigacion Biomedica en Red; CIBEROBN
RP Sola, E (corresponding author), Doctor Peset Univ Hosp, Serv Endocrinol, Valencia, Spain.
EM solaeva@gva.es
RI España, Francisco/A-7286-2008; Corella, Dolores/L-9888-2014; Hernandez
   Mijares, Antonio/D-3411-2011; Hernandez Mijares, Antonio/D-3411-2011
OI Hernandez Mijares, Antonio/0000-0003-4099-1905; Hernandez Mijares,
   Antonio/0000-0003-2197-0607; Espana, Francisco/0000-0001-7829-2021
FU Instituto de Salud Carlos III CIBER [06/03/0035, CB06/02/0045]
FX This work was supported by research grants from Instituto de Salud
   Carlos III CIBER 06/03/0035 and CIBER CB06/02/0045 (CIBER Actions,
   Epidemiology and Public Health). We thank Alicia Ricart for her help in
   English translation and Amparo Romero and Montserrat Martinez for their
   technical assistance.
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NR 35
TC 32
Z9 35
U1 1
U2 9
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1930-7381
EI 1930-739X
J9 OBESITY
JI Obesity
PD FEB
PY 2009
VL 17
IS 2
BP 318
EP 322
DI 10.1038/oby.2008.499
PG 5
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 400VJ
UT WOS:000262897200017
PM 19023282
OA Bronze
DA 2025-06-11
ER

PT J
AU Belsham, DD
   Dalvi, PS
AF Belsham, Denise D.
   Dalvi, Prasad S.
TI Insulin signalling in hypothalamic neurones
SO JOURNAL OF NEUROENDOCRINOLOGY
LA English
DT Review
DE hypothalamus; insulin resistance; insulin signalling; neuropeptides
ID CENTRAL-NERVOUS-SYSTEM; ENDOPLASMIC-RETICULUM STRESS; DIET-INDUCED
   OBESITY; BETA/NF-KAPPA-B; HIGH-FAT DIET; FOOD-INTAKE; ER STRESS; ARCUATE
   NUCLEUS; GENE-EXPRESSION; POMC NEURONS
AB Subsequent to the discovery of insulin by Banting and Best in the Department of Physiology at the University of Toronto 100 years ago, the field of insulin signalling and action has grown at a remarkable pace. Yet, the recognition that insulin action in the brain is critical for whole body homeostasis has only recently been appreciated. The hypothalamus is a key region in the brain that responds to circulating insulin by engaging a complex signalling cascade resulting in the ultimate release of neuropeptides that control hunger and feeding. Disruption of this important feedback system can lead to a phenomenon called cellular insulin resistance, where the neurones cease to sense insulin. The factors contributing to insulin resistance, as well as the resulting detrimental effects, include the induction of neuroinflammation, endoplasmic reticulum stress and alterations in the architecture of the blood-brain barrier that allow transport of insulin into the brain. These manifestations usually change energy balance, causing weight gain, often resulting in obesity and its deadly comorbidities, including type 2 diabetes mellitus, cardiovascular disease and metabolic syndrome. Nonetheless, there is still hope because the signal transduction pathways can be targeted at a number of levels by neurone-specific therapeutics. With the advent of unique cell models for investigating the mechanisms involved in these processes, the discovery of novel targets is increasingly possible. Although we are still looking for a cure for diabetes, Banting and Best would be impressed at how far their discovery has advanced and the contemporary knowledge that has been accumulated based on insulin action.
C1 [Belsham, Denise D.] Univ Toronto, Dept Physiol, Med Sci Bldg 3247A,1 Kings Coll Circle, Toronto, ON M5S 1A8, Canada.
   [Belsham, Denise D.] Univ Toronto, Dept Obstet & Gynaecol, Toronto, ON, Canada.
   [Belsham, Denise D.] Univ Toronto, Dept Med, Toronto, ON, Canada.
   [Dalvi, Prasad S.] Gannon Univ, Morosky Coll Hlth Profess & Sci, Biol Dept, Erie, PA USA.
C3 University of Toronto; University of Toronto; University of Toronto;
   Gannon University
RP Belsham, DD (corresponding author), Univ Toronto, Dept Physiol, Med Sci Bldg 3247A,1 Kings Coll Circle, Toronto, ON M5S 1A8, Canada.
EM d.beisham@utoronto.ca
OI Belsham, Denise/0000-0002-7065-8591
FU Canadian Institutes of Health Research; Natural Sciences and Engineering
   Research Council of Canada
FX Canadian Institutes of Health Research; Natural Sciences and Engineering
   Research Council of Canada
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NR 145
TC 19
Z9 24
U1 2
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0953-8194
EI 1365-2826
J9 J NEUROENDOCRINOL
JI J. Neuroendocrinol.
PD APR
PY 2021
VL 33
IS 4
SI SI
AR e12919
DI 10.1111/jne.12919
EA NOV 2020
PG 14
WC Endocrinology & Metabolism; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology
GA RU2RM
UT WOS:000591441100001
PM 33227171
DA 2025-06-11
ER

PT J
AU Romero, M
   Toral, M
   Robles-Vera, I
   Sánchez, M
   Jiménez, R
   O'Valle, F
   Rodriguez-Nogales, A
   Pérez-Vizcaino, F
   Gálvez, J
   Duarte, J
AF Romero, Miguel
   Toral, Marta
   Robles-Vera, Inaki
   Sanchez, Manuel
   Jimenez, Rosario
   O'Valle, Francisco
   Rodriguez-Nogales, Alba
   Perez-Vizcaino, Francisco
   Galvez, Julio
   Duarte, Juan
TI Activation of Peroxisome Proliferator Activator Receptor / Improves
   Endothelial Dysfunction and Protects Kidney in Murine Lupus
SO HYPERTENSION
LA English
DT Article
DE acetylcholine; blood pressure; hypertension; nephritis; oxidative
   stress; peroxisome; proliferator-activated receptors
ID DECREASES BLOOD-PRESSURE; APOPTOTIC CELLS; MOUSE MODEL; METABOLIC
   SYNDROME; PPAR-BETA/DELTA; CARDIOVASCULAR-DISEASE; AUTOIMMUNE-DISEASE;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; UP-REGULATION
AB Women with systemic lupus erythematosus exhibit a high prevalence of hypertension, endothelial dysfunction, and renal injury. We tested whether GW0742, a peroxisome proliferator activator receptor / (PPAR/) agonist, ameliorates disease activity and cardiovascular complications in a female mouse model of lupus. Thirty-week-old NZBWF1 (lupus) and NZW/LacJ (control) mice were treated with GW0742 or with the PPAR/ antagonist GSK0660 plus GW0742 for 5 weeks. Blood pressure, plasma double-stranded DNA autoantibodies and cytokines, nephritis, hepatic opsonins, spleen lymphocyte populations, endothelial function, and vascular oxidative stress were compared in treated and untreated mice. GW0742 treatment reduced lupus disease activity, blood pressure, cardiac and renal hypertrophy, splenomegaly, albuminuria, and renal injury in lupus mice, but not in control. GW0742 increased hepatic opsonins mRNA levels in lupus mice and reduced the elevated T, B, Treg, and Th1 cells in spleens from lupus mice. GW0742 lowered the higher plasma concentration of proinflammatory cytokines observed in lupus mice. Aortae from lupus mice showed reduced endothelium-dependent vasodilator responses to acetylcholine and increased nicotinamide adenine dinucleotide phosphate oxidase-driven vascular reactive oxygen species production, which were normalized by GW0742 treatment. All these effects of GW0742 were inhibited by PPAR/ blockade with GSK0660. Pharmacological activation of PPAR/ reduced hypertension, endothelial dysfunction, and organ damage in severe lupus mice, which was associated with reduced plasma antidouble-stranded DNA autoantibodies and anti-inflammatory and antioxidant effects in target tissues. Our findings identify PPAR/ as a promising target for an alternative approach in the treatment of systemic lupus erythematosus and its associated vascular damage.
C1 [Romero, Miguel; Toral, Marta; Robles-Vera, Inaki; Sanchez, Manuel; Jimenez, Rosario; Rodriguez-Nogales, Alba; Perez-Vizcaino, Francisco; Galvez, Julio; Duarte, Juan] Univ Granada, Sch Pharm, Dept Pharmacol, E-18071 Granada, Spain.
   [O'Valle, Francisco] Univ Granada, Sch Med, Dept Pathol, Granada, Spain.
   [Galvez, Julio] Univ Granada, Ctr Biomed Res CIBM, CIBER EHD, Granada, Spain.
   [Romero, Miguel; Jimenez, Rosario; O'Valle, Francisco; Galvez, Julio; Duarte, Juan] Ibs GRANADA, Inst Invest Biosanitaria Granada, Granada, Spain.
   [Jimenez, Rosario; Duarte, Juan] CIBER Enfermedades Cardiovasc, Granada, Spain.
   [Perez-Vizcaino, Francisco] Univ Complutense Madrid, Sch Med, Dept Pharmacol, Madrid, Spain.
   [Perez-Vizcaino, Francisco] CIBER Enfermedades Resp, Madrid, Spain.
   [Perez-Vizcaino, Francisco] IiSGM, Madrid, Spain.
C3 University of Granada; University of Granada; CIBER - Centro de
   Investigacion Biomedica en Red; CIBEREHD; University of Granada;
   Instituto de Investigacion Biosanitaria IBS Granada; CIBER - Centro de
   Investigacion Biomedica en Red; CIBERCV; Complutense University of
   Madrid; CIBER - Centro de Investigacion Biomedica en Red; CIBERES
RP Duarte, J (corresponding author), Univ Granada, Sch Pharm, Dept Pharmacol, E-18071 Granada, Spain.
EM jmduarte@ugr.es
RI Duarte, Juan/AAH-1574-2020; Robles-Vera, Iñaki/AAF-8562-2019; O¨Valle,
   Francisco/AAA-9151-2019; Rodríguez-Nogales, Alba/J-2782-2017; Toral,
   Marta/K-6709-2014; Perez-Vizcaino, Francisco/A-9735-2011; Robles Vera,
   Inaki/K-6355-2017; Sanchez, Manuel/C-4401-2008; JIMENEZ,
   ROSARIO/K-9701-2014; Galvez, Julio/K-6875-2014; Duarte,
   Juan/K-6472-2014; Romero, Miguel/K-6053-2014
OI Toral, Marta/0000-0001-5324-8569; Perez-Vizcaino,
   Francisco/0000-0001-6309-7418; Robles Vera, Inaki/0000-0001-6002-9241;
   Sanchez, Manuel/0000-0002-3975-3398; JIMENEZ,
   ROSARIO/0000-0003-3872-2669; Galvez, Julio/0000-0001-6876-3782; Duarte,
   Juan/0000-0002-9153-5857; Romero, Miguel/0000-0003-0578-1099
FU Ministerio de Economia y Competitividad [SAF2010-22066-C02-01,
   SAF2011-28150, SAF2014-55523-R, AGL2015-67995-C3-3-R]; Junta de
   Andalucia (Proyecto de excelencia) [P12-CTS-2722, CTS 164]; European
   Union (Fondo Europeo de Desarrollo Regional FEDER); Instituto de Salud
   Carlos III (Red de Investigacion Cardiovascular [RIC], CIBER-EHD), Spain
   [RD12/0042/0011]
FX This work was supported by Grants from Ministerio de Economia y
   Competitividad (SAF2010-22066-C02-01, SAF2011-28150, SAF2014-55523-R and
   AGL2015-67995-C3-3-R), by Junta de Andalucia (Proyecto de excelencia,
   P12-CTS-2722 and CTS 164) with funds from the European Union (Fondo
   Europeo de Desarrollo Regional FEDER), and by the Instituto de Salud
   Carlos III (Red de Investigacion Cardiovascular [RIC], RD12/0042/0011,
   CIBER-EHD), Spain. M. Romero is a postdoctoral fellow of RIC, M. Sanchez
   is a postdoctoral fellow of Junta de Andalucia, A. Rodriguez-Nogales is
   a postdoctoral fellow, and I. Robles-Vera is a predoctoral fellow of the
   Plan Propio de Investigacion, University of Granada, Spain.
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NR 56
TC 28
Z9 32
U1 0
U2 13
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0194-911X
EI 1524-4563
J9 HYPERTENSION
JI Hypertension
PD APR
PY 2017
VL 69
IS 4
BP 641
EP 650
DI 10.1161/HYPERTENSIONAHA.116.08655
PG 10
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA EN1DN
UT WOS:000395750800021
PM 28242713
DA 2025-06-11
ER

PT J
AU Yuan, F
   Teng, X
   Guo, Z
   Zhou, JJ
   Zhang, Y
   Wang, S
AF Yuan, Fang
   Teng, Xu
   Guo, Zan
   Zhou, Jing-Jing
   Zhang, Yi
   Wang, Sheng
TI Chronic intermittent hypobaric hypoxia ameliorates endoplasmic reticulum
   stress mediated liver damage induced by fructose in rats
SO LIFE SCIENCES
LA English
DT Article
DE Chronic intermittent hypobaric hypoxia; Metabolic syndrome; Hepar;
   Apoptosis; Endoplasmic reticulum stress
ID FATTY LIVER; NONALCOHOLIC STEATOHEPATITIS; INSULIN-RESISTANCE; DISEASE;
   APOPTOSIS; MICE; ACCUMULATION; HEPATOCYTES; DEFICIENCY; MODEL
AB Aim: High-fructose intake induces nonalcoholic fatty liver disease (NAFLD) and chronic intermittent hypobaric hypoxia (CIHH) has beneficial effects on the body. We hypothesized that CIHH has protective effects on the impaired hepar in fructose-fed rats.
   Main methods: Sprague-Dawley rats (male, 160-180 g) were randomly divided into 4 groups: control group (CON), fructose group (FRUC, 10% fructose in drinking water for 6 weeks), CIHH group (simulated 5000 m altitude, 6 h per day for 6 weeks), and CIHH plus fructose groups (CIHH-F). Histopathology of liver, arterial blood pressure, blood biochemicals, hepatocyte apoptosis, and marker proteins of endoplasmic reticulum stress (ERS) were measured.
   Key findings: The arterial blood pressure, body mass index, abdominal fat weight and liver weight were increased in FRUC rats but not in CIHH-F rats. Likewise, the serum glucose, insulin, insulin C peptide, triglyceride (TG) and total cholesterol (TC) were elevated in FRUC rats but not in CIHH-F rats after fasting 12 h. Meanwhile, the hepatic steatosis and hepatocyte apoptosis occurred in FRUC rats but not in CIHH-F rats. Finally the expression of ERS markers including GRP78 (glucose-regulated protein78), CHOP (C/EBP Homologous Protein), and caspase-12 in hepatic tissue were up-regulated in FRUC rats, but such up-regulation was not observed in CIHH-F rats.
   Significance: Our results suggest that CIHH protect hepar against hepatic damage through inhibition of ERS in fructose-fed rats. CIHH might be the new therapy for NAFLD. (c) 2014 Elsevier Inc. All rights reserved.
C1 [Yuan, Fang; Teng, Xu; Guo, Zan; Zhou, Jing-Jing; Zhang, Yi; Wang, Sheng] Hebei Med Univ, Dept Physiol, Shijiazhuang 050017, Peoples R China.
   [Teng, Xu] Hebei Med Univ, Hebei Key Lab Lab Anim, Shijiazhuang 050017, Peoples R China.
   [Yuan, Fang; Zhou, Jing-Jing; Zhang, Yi; Wang, Sheng] Hebei Collaborat Innovat Ctr Cardiocerebrovasc Di, Shijiazhuang, Peoples R China.
C3 Hebei Medical University; Hebei Medical University
RP Zhang, Y (corresponding author), Hebei Med Univ, Dept Physiol, Shijiazhuang 050017, Peoples R China.
EM zhyheruy@hotmail.com; wangsheng@hebmu.edu.cn
RI ZHOU, JINGJING/S-3526-2017; Zhang, Yipu/GXV-8541-2022
OI Teng, Xu/0000-0003-2206-8308; Wang, Sheng/0000-0001-9579-4808
FU National Science Foundation of China [81100229]; Natural Science
   Foundation of Hebei Province [C2012206063]
FX This study was supported by the National Science Foundation of China
   (No. 81100229), and the Natural Science Foundation of Hebei Province
   (No. C2012206063).
CR [Anonymous], POSTGRADUATE MED
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NR 37
TC 22
Z9 25
U1 0
U2 18
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0024-3205
EI 1879-0631
J9 LIFE SCI
JI Life Sci.
PD JAN 15
PY 2015
VL 121
BP 40
EP 45
DI 10.1016/j.lfs.2014.11.019
PG 6
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA CB4IG
UT WOS:000349590800007
PM 25476828
DA 2025-06-11
ER

PT J
AU Uribarri, J
   Cai, WJ
   Ramdas, M
   Goodman, S
   Pyzik, R
   Chen, X
   Zhu, L
   Striker, GE
   Vlassara, H
AF Uribarri, Jaime
   Cai, Weijing
   Ramdas, Maya
   Goodman, Susan
   Pyzik, Renata
   Chen, Xue
   Zhu, Li
   Striker, Gary E.
   Vlassara, Helen
TI Restriction of Advanced Glycation End Products Improves Insulin
   Resistance in Human Type 2 Diabetes Potential role of AGER1 and SIRT1
SO DIABETES CARE
LA English
DT Article
ID METABOLIC SYNDROME; OXIDATIVE STRESS; OXIDANT STRESS; RISK-FACTOR;
   INFLAMMATION; GLYCOTOXINS; SENSITIVITY; EXPRESSION; MEDIATORS; FOODS
AB OBJECTIVE-Increased oxidative stress (OS) and impaired anti-OS defenses are important in the development and persistence of insulin resistance (IR). Several anti-inflammatory and cell-protective mechanisms, including advanced glycation end product (AGE) receptor-1 (AGER1) and sirtuin (silent mating-type information regulation 2 homolog) 1 (SIRT1) are suppressed in diabetes. Because basal OS in type 2 diabetic patients is influenced by the consumption of AGEs, we examined whether AGE consumption also affects IR and whether AGER1 and SIRT1 are involved.
   RESEARCH DESIGN AND METHODS-The study randomly assigned 36 subjects, 18 type 2 diabetic patients (age 61 +/- 4 years) and 118 healthy subjects (age 67 +/- 1.4 years), to a standard diet (>20 AGE equivalents [Eq]/day) or an isocaloric AGE-restricted diet (<10 AGE Eq/day) for 4 months. Circulating metabolic and inflammatory markers were assessed. Expression and activities of AGER1 and SIRT1 were examined in patients' peripheral blood mononuclear cells (PMNC) and in AGE-stimulated, AGER1-transduced (AGER1(+)), or AGER1-silenced human monocyte-like THP-1 cells.
   RESULTS-Insulin and homeostasis model assessment, leptin, tumor necrosis factor-a and nuclear factor-kappa B p65 acetylation, serum AGEs, and 8-isoprostanes decreased in AGE-restricted type 2 diabetic patients, whereas PMNC AGER1 and SIRT1 mRNA, and protein levels normalized and adiponectin markedly increased. AGEs suppressed AGER1, SIRT-1, and NAD(+) levels in THP-1 cells. These effects were inhibited in AGER1(+) but were enhanced in AGER1-silenced cells.
   CONCLUSIONS Food-derived pro-oxidant AGEs may contribute to IR in clinical type 2 diabetes and suppress protective mechanisms, AGER1 and SIRT1. AGE restriction may preserve native defenses and insulin sensitivity by maintaining lower basal OS.
C1 [Cai, Weijing; Ramdas, Maya; Goodman, Susan; Pyzik, Renata; Chen, Xue; Zhu, Li; Striker, Gary E.; Vlassara, Helen] Mt Sinai Sch Med, Dept Geriatr, New York, NY 10029 USA.
   [Uribarri, Jaime; Striker, Gary E.] Mt Sinai Sch Med, Dept Med, New York, NY USA.
C3 Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at
   Mount Sinai
RP Vlassara, H (corresponding author), Mt Sinai Sch Med, Dept Geriatr, New York, NY 10029 USA.
EM helen.vlassara@mssm.edu
RI Uribarri, Jaime/ADX-7655-2022
OI uribarri, jaime/0000-0001-9826-1134
FU MERIT [AG-23188, AG-09453]; National Institutes of Health, National
   Institute of Research Resources [M01-RR-00071]
FX This work was supported by MERIT grants AG-23188 and AG-09453 (to H.V.)
   and from the National Institutes of Health, National Institute of
   Research Resources (Grant M01-RR-00071) to the General Clinical Research
   Center at Mount Sinai School of Medicine for clinical and statistical
   support.
CR Cai WJ, 2008, AM J PATHOL, V173, P327, DOI 10.2353/ajpath.2008.080152
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NR 25
TC 271
Z9 287
U1 3
U2 51
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0149-5992
EI 1935-5548
J9 DIABETES CARE
JI Diabetes Care
PD JUL
PY 2011
VL 34
IS 7
BP 1610
EP 1616
DI 10.2337/dc11-0091
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 799CN
UT WOS:000293261200033
PM 21709297
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Wu, JHY
   Hodgson, JM
   Puddey, IB
   Belski, R
   Burke, V
   Croft, KD
AF Wu, J. H. Y.
   Hodgson, J. M.
   Puddey, I. B.
   Belski, R.
   Burke, V.
   Croft, K. D.
TI Sesame supplementation does not improve cardiovascular disease risk
   markers in overweight men and women
SO NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
LA English
DT Article
DE Cardiovascular disease; Risk factors; Sesame; Lignans
ID SALT HYPERTENSIVE-RATS; FATTY-ACID OXIDATION; NITRIC-OXIDE; ENDOTHELIAL
   DYSFUNCTION; SERUM CONCENTRATIONS; METABOLIC SYNDROME; DIETARY SESAMIN;
   ENTEROLACTONE; STRESS; LIGNAN
AB Background and aims: Pre-clinical studies suggest that sesame and its lignans induce beneficial changes in risk factors related to cardiovascular disease and increase the bioavailability of mammalian lignans. However, only very few intervention trials have investigated the potential bioactivities of sesame in humans. We aimed to investigate the effects of sesame supplementation in humans on blood lipids, blood pressure, systemic oxidative stress, inflammatory biomarkers and mammalian lignan metabolism.
   Methods and results: We conducted a randomized, placebo-controlled cross-over intervention trial at a university research centre. Overweight or obese men and women (n = 33) consumed 25 g/d of sesame (similar to 50 mg/d of sesame lignan) and an iso-caloric placebo matched for macro-nutrient composition for 5 wks each. Each intervention period was preceded by a 4-wk washout period. Blood lipid profiles, day time ambulatory blood pressure, oxidative stress and inflammatory biomarkers and urinary mammalian lignans were measured before and after each intervention. Results are presented as the effect of sesame supplementation relative to placebo. Urinary excretion of the mammalian lignans, enterolactone and enterodiol, increased by approximately 8-fold (P < 0.001). Blood lipids and blood pressure were not altered. In addition, markers of systemic inflammation (C-reactive protein, interleukin-6, tumor necrosis factor-a.) and lipid peroxidation (F-2-isoprostanes) were not affected.
   Conclusion: Supplementation with 25 g/d of sesame can significantly increase the exposure to mammalian lignans. However, this did not cause any improvement in markers of cardiovascular disease risk in overweight or obese men and women. (c) 2009 Elsevier B.V. All rights reserved.
C1 [Wu, J. H. Y.; Hodgson, J. M.; Puddey, I. B.; Belski, R.; Burke, V.; Croft, K. D.] Univ Western Australia, Sch Med & Pharmacol, Perth, WA 6847, Australia.
C3 University of Western Australia
RP Wu, JHY (corresponding author), Univ Western Australia, Sch Med & Pharmacol, POB X2213 GPO, Perth, WA 6847, Australia.
EM jwu@meddent.uwa.edu.au
RI Puddey, Ian/H-5673-2014; Belski, Regina/LNR-3606-2024; Hodgson,
   Jonathan/C-3900-2008; Croft, Kevin/C-4675-2013; Wu, Jason/J-2936-2019
OI Croft, Kevin/0000-0003-1596-4913; Wu, Jason/0000-0003-2073-3562;
   Hodgson, Jonathan/0000-0001-6184-7764; Belski,
   Regina/0000-0002-8836-3417
FU National Health and Medical Research Council (NHMRC) of Australia
   [403957]; University of Western Australia
FX This study was funded by the National Health and Medical Research
   Council (NHMRC) of Australia (project grant 403957). JW acknowledges the
   assistance of a Faculty of Medicine, Dentistry and Health Sciences
   Fellowship from the University of Western Australia.
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NR 30
TC 36
Z9 37
U1 0
U2 9
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0939-4753
EI 1590-3729
J9 NUTR METAB CARDIOVAS
JI Nutr. Metab. Carbiovasc. Dis.
PD DEC
PY 2009
VL 19
IS 11
BP 774
EP 780
DI 10.1016/j.numecd.2009.01.003
PG 7
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism; Nutrition
   & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism;
   Nutrition & Dietetics
GA 544BQ
UT WOS:000273626800004
PM 19346113
DA 2025-06-11
ER

PT J
AU Kume, D
   Nishiwaki, M
   Hotta, N
   Endoh, H
AF Kume, Daisuke
   Nishiwaki, Masato
   Hotta, Norio
   Endoh, Hiroshi
TI Impact of acute mental stress on segmental arterial stiffness
SO EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
LA English
DT Article
DE Pulse wave velocity; Cardio-ankle vascular index; Cardiovascular
   disease; Heart rate; Blood pressure
ID PULSE-WAVE VELOCITY; SYMPATHETIC-NERVE ACTIVITY; ALL-CAUSE MORTALITY;
   BLOOD-PRESSURE; ENDOTHELIAL DYSFUNCTION; CARDIOVASCULAR EVENTS;
   NEUROVASCULAR RESPONSES; AUGMENTATION INDEX; METABOLIC SYNDROME;
   ARITHMETIC STRESS
AB Purpose It has been reported that acute brief episodes of mental stress (MS) result in a prolonged increase in carotid-femoral pulse wave velocity (cfPWV), an index of aortic stiffness. However, whether acute MS also impacts arterial stiffness in other segments is unclear. The present study aimed to examine the impact of acute MS on segmental arterial stiffness. Methods In the main experiment, 17 young male subjects (mean age, 20.1 +/- 0.7 years) performed a 5-min MS and control (CON) task in a random order. Pulse wave velocity (PWV) from the heart to the brachium (hbPWV) and the ankle (haPWV), PWV between the brachial artery and the ankle (baPWV), and the cardio-ankle vascular index (CAVI) were simultaneously measured at baseline and 5, 15, and 30 min after the task. Results Compared to baseline values, hbPWV, baPWV, haPWV, and CAVI significantly increased until 30 min after the MS task, whereas these variables did not significantly change following the CON task. At 5 and 30 min after the MS task, percentage changes from baseline were significantly higher in hbPWV (+ 5.2 +/- 4.4 and 6.6 +/- 4.9%) than in baPWV (+ 2.2 +/- 2.1 and 2.2 +/- 2.0%) or haPWV (+ 3.6 +/- 2.6 and 4.3 +/- 2.9%) and were also significantly lower in baPWV than in haPWV. Conclusion These findings suggest that acute MS elicits an increase in arterial stiffness in various segments and this arterial stiffening is not uniform among the segments.
C1 [Kume, Daisuke] Okinawa Univ, Dept Hlth Sports & Welf, 555 Kokuba, Naha, Okinawa 9028521, Japan.
   [Nishiwaki, Masato] Osaka Inst Technol, Fac Engn, Asahi Ku, 5-16-1 Omiya, Osaka 5358585, Japan.
   [Hotta, Norio] Chubu Univ, Dept Lifelong Sports & Hlth Sci, 1200 Matsumoto Cho, Kasugai, Aichi 4878501, Japan.
   [Endoh, Hiroshi] Univ Ryukyus, Dept Hlth & Phys Educ, 1 Senbaru, Nishihara, Okinawa 9030213, Japan.
C3 Osaka Institute of Technology; Chubu University; University of the
   Ryukyus
RP Kume, D (corresponding author), Okinawa Univ, Dept Hlth Sports & Welf, 555 Kokuba, Naha, Okinawa 9028521, Japan.
EM kome_dai_128@yahoo.co.jp
RI Kume, Daisuke/MCJ-0212-2025
FU Grants-in-Aid for Scientific Research [20K11480] Funding Source: KAKEN
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NR 56
TC 25
Z9 27
U1 0
U2 7
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1439-6319
EI 1439-6327
J9 EUR J APPL PHYSIOL
JI Eur. J. Appl. Physiol.
PD OCT
PY 2020
VL 120
IS 10
BP 2247
EP 2257
DI 10.1007/s00421-020-04448-9
EA JUL 2020
PG 11
WC Physiology; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Physiology; Sport Sciences
GA NQ5BY
UT WOS:000552934000001
PM 32720134
DA 2025-06-11
ER

PT J
AU Pang, KL
   Chin, KY
AF Pang, Kok-Lun
   Chin, Kok-Yong
TI The Role of Tocotrienol in Protecting Against Metabolic Diseases
SO MOLECULES
LA English
DT Review
DE adipose; diabetes; insulin resistance; metabolic syndrome; obesity;
   overweight; vitamin E
ID RICE BRAN OIL; BETA-CAROTENE SUPPLEMENTATION; LONG-CHAIN
   CARBOXYCHROMANOLS; ALPHA-TOCOPHEROL; GAMMA-TOCOTRIENOL; VITAMIN-E;
   OXIDATIVE STRESS; PALM OIL; DIABETES-MELLITUS; DOUBLE-BLIND
AB Obesity is a major risk factor for diabetes, and these two metabolic conditions cause significant healthcare burden worldwide. Chronic inflammation and increased oxidative stress due to exposure of cells to excess nutrients in obesity may trigger insulin resistance and pancreatic beta-cell dysfunction. Tocotrienol, as a functional food component with anti-inflammatory, antioxidant, and cell signaling-mediating effects, may be a potential agent to complement the current management of obesity and diabetes. The review aimed to summarize the current evidence on the anti-obesity and antidiabetic effects of tocotrienol. Previous studies showed that tocotrienol could suppress adipogenesis and, subsequently, reduce body weight and fat mass in animals. This was achieved by regulating pathways of lipid metabolism and fatty acid biosynthesis. It could also reduce the expression of transcription factors regulating adipogenesis and increase apoptosis of adipocytes. In diabetic models, tocotrienol was shown to improve glucose homeostasis. Activation of peroxisome proliferator-activated receptors was suggested to be responsible for these effects. Tocotrienol also prevented multiple systemic complications due to obesity and diabetes in animal models through suppression of inflammation and oxidative stress. Several clinical trials have been conducted to validate the antidiabetic of tocotrienol, but the results were heterogeneous. There is no evidence showing the anti-obesity effects of tocotrienol in humans. Considering the limitations of the current studies, tocotrienol has the potential to be a functional food component to aid in the management of patients with obesity and diabetes.
C1 [Pang, Kok-Lun] Univ Reading Malaysia, Sch Pharm, Iskandar Puteri Johor 79200, Malaysia.
   [Chin, Kok-Yong] Univ Kebangsaan Malaysia, Dept Pharmacol, Fac Med, Kuala Lumpur 56000, Malaysia.
C3 Universiti Kebangsaan Malaysia
RP Chin, KY (corresponding author), Univ Kebangsaan Malaysia, Dept Pharmacol, Fac Med, Kuala Lumpur 56000, Malaysia.
EM k.l.pang@reading.edu.my; chinkokyong@ppukm.ukm.edu.my
RI Pang, Kok/W-2157-2019; Chin, Kok-Yong/B-6309-2015
OI Chin, Kok-Yong/0000-0001-6628-1552; Pang, Kok Lun/0000-0003-2219-6297
FU Universiti KebangsaanMalaysia [GUP-2017-060, FF-2018-405]
FX This project is funded by Universiti KebangsaanMalaysia through grants
   GUP-2017-060 and FF-2018-405.
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NR 129
TC 62
Z9 62
U1 3
U2 25
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 1420-3049
J9 MOLECULES
JI Molecules
PD MAR 1
PY 2019
VL 24
IS 5
AR 923
DI 10.3390/molecules24050923
PG 25
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA HQ8GR
UT WOS:000462662900099
PM 30845769
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU da Silveira, CG
   Di Domenico, M
   Saldiva, PHN
   Rhoden, CR
AF da Silveira, Caroline Gamalho
   Di Domenico, Marlise
   Nascimento Saldiva, Paulo Hilario
   Rhoden, Claudia Ramos
TI Subchronic air pollution exposure increases highly palatable food
   intake, modulates caloric efficiency and induces lipoperoxidation
SO INHALATION TOXICOLOGY
LA English
DT Article
DE Air pollution; particulate matter; ROFA; oxidative stress; antioxidants;
   highly palatable food
ID FINE PARTICULATE MATTER; OXIDATIVE STRESS; LIPID-PEROXIDATION; METABOLIC
   SYNDROME; HDL CHOLESTEROL; FATTY-ACIDS; CHOCOLATE; DIET; OBESITY; HEALTH
AB The investigation of the relationship between air pollution and obesity has captured the interest of researchers. However, the mechanism regarding the association between air pollution exposure and metabolic diseases and obesity still remains unclear. We aimed to investigate the effects of subchronic ROFA exposure on consumption and preference for highly palatable food and its interference on biochemical, lipid and oxidative stress parameters in rats. Male Wistar rats were divided in groups: control, ROFA, chocolate and ROFA+chocolate. Rats were exposed to ROFA during 18weeks and to palatable food in the last 30days. Food consumption, caloric intake and caloric efficiency, body mass gain, abdominal fat deposition, glucose and lipid profile were measured. Thiobarbituric acid reactive substances (TBARS), catalase (CAT) and superoxide dismutase (SOD) activity were assessed in lungs, heart, pancreas and hypothalamus. Chocolate intake was higher in the first and second weeks in rats exposed to ROFA while the standard chow intake was smaller in second and third weeks. The amount of kilocalories derived from chocolate was higher in the animals exposed to ROFA in all weeks. The caloric intake and body mass gain were not different among groups. Triglycerides, total cholesterol and HDL were higher in chocolate exposed rats. The TBARS was higher in lung and heart in ROFA group and in hypothalamus in ROFA+chocolate group. There were no significant differences in glucose, LDL and antioxidant enzymes. These findings indicate that subcronic air pollution exposure can modulate metabolic effects of subacute exposure to chocolate in adulthood.
C1 [da Silveira, Caroline Gamalho; Di Domenico, Marlise; Rhoden, Claudia Ramos] Univ Fed Ciencias Saude Porto Alegre, Lab Poluicao Atmosfer, Porto Alegre, RS, Brazil.
   [Di Domenico, Marlise; Nascimento Saldiva, Paulo Hilario] Univ Sao Paulo, Fac Med, Lab Poluicao Atmosfer Expt, Sao Paulo, Brazil.
C3 Universidade Federal de Ciencias da Saude de Porto Alegre; Universidade
   de Sao Paulo
RP da Silveira, CG (corresponding author), Univ Fed Ciencias Saude Porto Alegre, Lab Poluicao Atmosfer, Porto Alegre, RS, Brazil.
EM carolbrs1990@hotmail.com
RI Saldiva, Paulo/D-7385-2012
FU Universidade Federal de Ciencias da Saude de Porto Alegre, Brazil;
   Conselho Nacional de Desenvolvimento Cientifico e Tecnologico-CNPq
FX This work was supported by Universidade Federal de Ciencias da Saude de
   Porto Alegre, Brazil. Dr. C.R. Rhoden and Dr. P.H.N. Saldiva are
   supported by Conselho Nacional de Desenvolvimento Cientifico e
   Tecnologico-CNPq.
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NR 79
TC 9
Z9 9
U1 0
U2 12
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0895-8378
EI 1091-7691
J9 INHAL TOXICOL
JI Inhal. Toxicol.
PY 2018
VL 30
IS 9-10
BP 370
EP 380
DI 10.1080/08958378.2018.1530317
PG 11
WC Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Toxicology
GA HK2EH
UT WOS:000457721400006
PM 30384793
DA 2025-06-11
ER

PT J
AU Mostafavi, E
   Nargesi, AA
   Asbagh, FA
   Ghazizadeh, Z
   Heidari, B
   Mirmiranpoor, H
   Esteghamati, A
   Vigneron, C
   Nakhjavani, M
AF Mostafavi, Ebrahim
   Nargesi, Arash Aghajani
   Asbagh, Firoozeh Akbari
   Ghazizadeh, Zaniar
   Heidari, Behnam
   Mirmiranpoor, Hossein
   Esteghamati, Alireza
   Vigneron, Claude
   Nakhjavani, Manouchehr
TI Abdominal obesity and gestational diabetes: the interactive role of
   magnesium
SO MAGNESIUM RESEARCH
LA English
DT Article
DE magnesium; abdominal obesity; gestational diabetes mellitus;
   inflammation; oxidative stress
ID C-REACTIVE PROTEIN; INTRACELLULAR MAGNESIUM; METABOLIC SYNDROME;
   INSULIN-RESISTANCE; DIETARY MAGNESIUM; OXIDATIVE STRESS; TYPE-2;
   MELLITUS; METAANALYSIS; SUPPLEMENTATION
AB Aims. Magnesium is a cofactor for numerous metabolic enzymatic reactions. It is required for glucose utilization and insulin signaling. We compared plasma magnesium concentrations in pregnant women with and without abdominal obesity, and investigated the interactive roles of magnesium and obesity in the development of gestational diabetes mellitus (GDM). Methods. Pregnant women with and without abdominal obesity (n = 40 in each group) were followed during gestation. Oral glucose tolerance tests (OGTT) were performed at 24-28 weeks of pregnancy to diagnose GDM. Plasma glucose, insulin, triglycerides, high-sensitive C-reactive protein (hs-CRP), and malondialdehyde (MDA) were measured. The obesity-GDM relationship was investigated prospectively, and the magnesium-GDM relationship was analyzed on a cross-sectional basis. Results. Sixteen patients in the obese group and one in the control developed GDM. There were no differences in plasma magnesium levels between obese and control groups (p-value = 0.14), but significant differences between diabetic and non-diabetic patients (p-value = 0.05). Fourteen out of 17 diabetic patients had magnesium concentrations below the median. Increases in insulin, homeostatic model for insulin resistance, triglycerides, hs-CRP, MDA and second-hour blood glucose were more pronounced in those with both abdominal obesity and low-normal magnesium concentrations. In the Poisson regression model, obesity (relative risk = 20.6, p-value = 0.002), low-normal magnesium level (relative risk = 4.2, p-value = 0.009), and their interaction (p-value<0.001) were significant. Conclusion. Abdominally obese patients with lower plasma magnesium are more likely to show abnormal OGTT results. Insulin resistance, inflammatory response and oxidative stress are exaggerated in these patients.
C1 [Mostafavi, Ebrahim; Asbagh, Firoozeh Akbari] Univ Tehran Med Sci, Mirza Kouchak Khan Womens Hosp, Dept Lab Med, Tehran, Iran.
   [Nargesi, Arash Aghajani; Ghazizadeh, Zaniar; Heidari, Behnam; Mirmiranpoor, Hossein; Esteghamati, Alireza; Nakhjavani, Manouchehr] Univ Tehran Med Sci, Endocrinol & Metab Res Ctr, Vali Asr Hosp, POB 14197-33147, Tehran, Iran.
   [Vigneron, Claude] Univ Lorraine, Cibles Therapeut & Formulat, Nancy, France.
C3 Tehran University of Medical Sciences; Tehran University of Medical
   Sciences; Universite de Lorraine
RP Nakhjavani, M (corresponding author), Univ Tehran Med Sci, Endocrinol & Metab Res Ctr, Vali Asr Hosp, POB 14197-33147, Tehran, Iran.
EM nakhjavanim@tums.ac.ir
RI Mousavi Khaneghah, Amin/A-5925-2012; Nakhjavani, Manouchehr/J-3704-2019;
   Nargesi, Arash/AAM-5298-2020; Mostafavi, Ehsan/A-7627-2011;
   Mirmiranpour, Hossein/U-6611-2017
OI Esteghamati, Alireza/0000-0001-5114-3982; Mostafavi,
   Ehsan/0000-0002-1997-517X; Mirmiranpour, Hossein/0000-0001-7666-0900
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NR 41
TC 12
Z9 13
U1 0
U2 6
PU JOHN LIBBEY EUROTEXT LTD
PI MONTROUGE
PA 127 AVE DE LA REPUBLIQUE, 92120 MONTROUGE, FRANCE
SN 0953-1424
EI 1952-4021
J9 MAGNESIUM RES
JI Magnes. Res.
PD DEC
PY 2015
VL 28
IS 4
BP 116
EP 124
DI 10.1684/mrh.2015.0392
PG 9
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA DD7YO
UT WOS:000370141100001
PM 26878251
DA 2025-06-11
ER

PT J
AU Hong, Y
   Hu, Y
   Sun, YA
   Shi, JQ
   Xu, J
AF Hong, Yin
   Hu, Yue
   Sun, Yong-an
   Shi, Jian-quan
   Xu, Jun
TI High-fat diet caused renal damage in ApoE<SUP>-/-</SUP> mice via the
   activation of RAGE-mediated inflammation
SO TOXICOLOGY RESEARCH
LA English
DT Article
DE high-fat diet; chronic kidney disease; inflammation; apoptosis;
   oxidative stress; RAGE
ID DIABETIC-NEPHROPATHY; INJURY; FRUCTOSE
AB High-fat diet (HFD) is the primary cause of metabolic syndrome associated chronic kidney disease. This study aimed to investigate the pathogenesis of HFD-induced kidney injury. ApoE(-/-) mice were fed with HFD and kidney damage was examined. In addition, HK-2 human renal proximal tubular epithelial cells were treated with fructose and receptor of advanced glycation end products (RAGE) siRNA. The results showed that HFD increased body weight, blood glucose and insulin resistance in ApoE(-/-) mice. The kidney damage was associated with increased oxidative stress and strong staining of RAGE and NF-kappa B in kidney tissues, as well as high serum levels of TNF-alpha, IL-1 beta and IL-6. Western-blot analysis showed that HFD increased the levels of RAGE, p-I kappa B alpha, p-NF-kappa B, bax, caspase-3 and caspase-9 but decreased the levels of Bcl-2 in kidney tissues. In HK-2 cells, fructose promoted the secretion of TNF-alpha, IL-1 beta and IL-6 and increased the levels of RAGE, p-I kappa B alpha, p-NF-kappa B, bax, caspase-3 and caspase-9, but decreased the levels of Bcl-2. Moreover, RAGE siRNA could attenuate increased levels of p-I kappa B alpha, p-NF-kappa B, bax, caspase-3 and caspase-9 while restore decreased levels of Bcl-2 in fructose-treated HK-2 cells. In conclusion, HFD causes kidney injury by promoting oxidative stress, inflammation and apoptosis possibly through the activation of RAGE/NF-kappa B pathway.
C1 [Hong, Yin] Capital Med Univ, Beijing Tian Tan Hosp, Dept Hlth Management, Beijing 100050, Peoples R China.
   [Hu, Yue] Yangzhou Univ, Dept Neurol, Affiliated Hosp, Yangzhou 225001, Jiangsu, Peoples R China.
   [Sun, Yong-an] Peking Univ, Dept Neurol, Hosp 1, Beijing 10068, Peoples R China.
   [Shi, Jian-quan; Xu, Jun] Capital Med Univ, Beijing Tian Tan Hosp, Cognit Ctr, Dept Neurol, Beijing 100070, Peoples R China.
C3 Capital Medical University; Yangzhou University; Peking University;
   Capital Medical University
RP Xu, J (corresponding author), Capital Med Univ, Beijing Tian Tan Hosp, Cognit Ctr, Dept Neurol, Beijing 100070, Peoples R China.
EM xujun@ccmu.edu.cn
RI Xu, Jun/MBV-5097-2025
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   Wyatt CM, 2017, KIDNEY INT, V91, P998, DOI 10.1016/j.kint.2017.03.004
NR 19
TC 5
Z9 5
U1 1
U2 5
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 2045-452X
EI 2045-4538
J9 TOXICOL RES-UK
JI Toxicol. Res.
PD DEC
PY 2021
VL 10
IS 6
BP 1171
EP 1176
DI 10.1093/toxres/tfab102
EA NOV 2021
PG 6
WC Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Toxicology
GA XV0NX
UT WOS:000734651000010
PM 34956620
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Oke, SL
   Lee, K
   Papp, R
   Laviolette, SR
   Hardy, DB
AF Oke, Shelby L.
   Lee, Kendrick
   Papp, Rosemary
   Laviolette, Steven R.
   Hardy, Daniel B.
TI In Utero Exposure to Δ9-Tetrahydrocannabinol Leads to Postnatal Catch-Up
   Growth and Dysmetabolism in the Adult Rat Liver
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE Delta 9-tetrahydrocannabinol; intrauterine growth restriction; liver;
   metabolism; triglycerides; oxidative stress; mitochondria; miR-203a-3p;
   miR-29a/b/c
ID FATTY LIVER; OXIDATIVE STRESS; DELTA(9)-TETRAHYDROCANNABINOL THC;
   MITOCHONDRIAL DYSFUNCTION; METABOLIC SYNDROME; TRIGLYCERIDE SYNTHESIS;
   PROTEIN RESTRICTION; INSULIN-RESISTANCE; HEPATIC STEATOSIS; PROFILING
   REVEALS
AB The rates of gestational cannabis use have increased despite limited evidence for its safety in fetal life. Recent animal studies demonstrate that prenatal exposure to Delta 9-tetrahydrocannabinol (Delta 9-THC, the psychoactive component of cannabis) promotes intrauterine growth restriction (IUGR), culminating in postnatal metabolic deficits. Given IUGR is associated with impaired hepatic function, we hypothesized that Delta 9-THC offspring would exhibit hepatic dyslipidemia. Pregnant Wistar rat dams received daily injections of vehicular control or 3 mg/kg Delta 9-THC i.p. from embryonic day (E) 6.5 through E22. Exposure to Delta 9-THC decreased the liver to body weight ratio at birth, followed by catch-up growth by three weeks of age. At six months, 49-THC-exposed male offspring exhibited increased visceral adiposity and higher hepatic triglycerides. This was instigated by augmented expression of enzymes involved in triglyceride synthesis (ACC alpha, SCD, FABP1, and DGAT2) at three weeks. Furthermore, the expression of hepatic DGAT1/DGAT2 was sustained at six months, concomitant with mitochondrial dysfunction (i.e., elevated p66shc) and oxidative stress. Interestingly, decreases in miR-203a-3p and miR-29a/b/c, both implicated in dyslipidemia, were also observed in these Delta 9-THC-exposed offspring. Collectively, these findings indicate that prenatal Delta 9-THC exposure results in long-term dyslipidemia associated with enhanced hepatic lipogenesis. This is attributed by mitochondrial dysfunction and epigenetic mechanisms.
C1 [Oke, Shelby L.; Lee, Kendrick; Papp, Rosemary; Hardy, Daniel B.] Western Univ, Schulich Sch Med & Dent, Dept Physiol & Pharmacol, 1151 Richmond St, London, ON N6A 5C1, Canada.
   [Oke, Shelby L.; Lee, Kendrick; Hardy, Daniel B.] Lawson Hlth Res Inst, Childrens Hlth Res Inst, London, ON N6A 5C1, Canada.
   [Laviolette, Steven R.; Hardy, Daniel B.] Western Univ, Schulich Sch Med & Dent, Dept Anat & Cell Biol, 1151 Richmond St, London, ON N6A 5C1, Canada.
   [Hardy, Daniel B.] Western Univ, Schulich Sch Med & Dent, Dept Obstet & Gynaecol, 1151 Richmond St, London, ON N6A 5C1, Canada.
C3 Western University (University of Western Ontario); Western University
   (University of Western Ontario); University Western Ontario Hospital;
   Western University (University of Western Ontario); Western University
   (University of Western Ontario)
RP Hardy, DB (corresponding author), Western Univ, Schulich Sch Med & Dent, Dept Physiol & Pharmacol, 1151 Richmond St, London, ON N6A 5C1, Canada.; Hardy, DB (corresponding author), Lawson Hlth Res Inst, Childrens Hlth Res Inst, London, ON N6A 5C1, Canada.; Hardy, DB (corresponding author), Western Univ, Schulich Sch Med & Dent, Dept Anat & Cell Biol, 1151 Richmond St, London, ON N6A 5C1, Canada.; Hardy, DB (corresponding author), Western Univ, Schulich Sch Med & Dent, Dept Obstet & Gynaecol, 1151 Richmond St, London, ON N6A 5C1, Canada.
EM soke2@uwo.ca; klee843@uwo.ca; rosiepapp@gmail.com;
   steven.laviolette@schulich.uwo.ca; daniel.hardy@schulich.uwo.ca
RI Hardy, Daniel/GYU-8976-2022
OI Hardy, Daniel/0000-0001-5445-273X
FU Canadian Institutes of Health Research Catalyst Grant [CRU1126];
   Canadian Heart and Stroke Foundation [G-19-0026343]; NSERC CGS-D
FX This work was supported by a Canadian Institutes of Health Research
   Catalyst Grant (CRU1126) to DBH and a Canadian Heart and Stroke
   Foundation Grant-in-Aid (G-19-0026343) to DBH. An NSERC CGS-D was
   awarded to SLO.
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NR 102
TC 17
Z9 18
U1 0
U2 5
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD JUL
PY 2021
VL 22
IS 14
AR 7502
DI 10.3390/ijms22147502
PG 24
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA TO2KH
UT WOS:000676747000001
PM 34299119
OA gold, Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Ciciliot, S
   Albiero, M
   Campanaro, S
   Poncina, N
   Tedesco, S
   Scattolini, V
   Dalla Costa, F
   Cignarella, A
   Vettore, M
   Di Gangi, IM
   Bogialli, S
   Avogaro, A
   Fadini, GP
AF Ciciliot, Stefano
   Albiero, Mattia
   Campanaro, Stefano
   Poncina, Nicol
   Tedesco, Serena
   Scattolini, Valentina
   Dalla Costa, Francesca
   Cignarella, Andrea
   Vettore, Monica
   Di Gangi, Iole Maria
   Bogialli, Sara
   Avogaro, Angelo
   Fadini, Gian Paolo
TI Interplay between gut microbiota and p66Shc affects
   obesity-associated insulin resistance
SO FASEB JOURNAL
LA English
DT Article
DE oxidative stress; inflammation; gut bacteria; microbiome; metabolic
   syndrome
ID HIGH-FAT DIET; OXIDATIVE STRESS; GLUCOSE-TOLERANCE; LIFE-SPAN; DELETION;
   HOST; MICE; PROMOTES; PROTECTS; GENE
AB The 66 kDa isoform of the mammalian Shc gene promotes adipogenesis, and p66Shc(-/-) mice accumulate less body weight than wild-type (WT) mice. As the metabolic consequences of the leaner phenotype of p66Shc(-/-) mice is debated, we hypothesized that gut microbiota may be involved. We confirmed that p66Shc(-/-) mice gained less weight than WT mice when on a high-fat diet (HFD), but they were not protected from insulin resistance and glucose intolerance. p66Shc deletion significantly modified the composition of gut microbiota and their modification after an HFD. This was associated with changes in gene expression of Il-1b and regenerating islet-derived protein 3 (Reg3g) in the gut and in systemic trimethylamine N-oxide and branched chain amino acid levels, despite there being no difference in intestinal structure and permeability. Depleting gut microbiota at the end of HFD rendered both strains more glucose tolerant but improved insulin sensitivity only in p66Shc(-/-) mice. Microbiota-depleted WT mice cohoused with microbiota-competent p66Shc(-/-) mice became significantly more insulin resistant than WT mice cohoused with WT mice, despite no difference in weight gain. These findings reconcile previous inconsistent observations on the metabolic phenotype of p66Shc(-/-) mice and illustrate the complex microbiome-host-genotype interplay under metabolic stress.Ciciliot, S., Albiero, M., Campanaro, S., Poncina, N., Tedesco, S., Scattolini, V., Dalla Costa, F., Cignarella, A., Vettore, M., Di Gangi, I. M., Bogialli, S., Avogaro, A., Fadini, G. P. Interplay between gut microbiota and p66Shc affects obesity-associated insulin resistance.
C1 [Ciciliot, Stefano; Albiero, Mattia; Poncina, Nicol; Tedesco, Serena; Scattolini, Valentina; Dalla Costa, Francesca; Fadini, Gian Paolo] Venetian Inst Mol Med, Padua, Italy.
   [Campanaro, Stefano] Univ Padua, Dept Biol, Padua, Italy.
   [Scattolini, Valentina; Cignarella, Andrea; Vettore, Monica; Avogaro, Angelo; Fadini, Gian Paolo] Univ Padua, Dept Med, Padua, Italy.
   [Di Gangi, Iole Maria; Bogialli, Sara] Univ Padua, Dept Chem, Padua, Italy.
C3 Veneto Institute Molecular Medicine; University of Padua; University of
   Padua; University of Padua
RP Fadini, GP (corresponding author), Univ Padua, Med Sch, Dept Med, Via Giustiniani 2, I-35128 Padua, Italy.
EM gianpaolo.fadini@unipd.it
RI Fadini, Gian/M-4575-2019; Avogaro, Angelo/S-3808-2016; Ciciliot,
   Stefano/L-3887-2019; Campanaro, Stefano/I-5657-2019; Albiero,
   Mattia/AAG-4257-2019; bogialli, sara/A-8677-2013
OI Cignarella, Andrea/0000-0002-4820-4876; bogialli,
   sara/0000-0002-9152-3602; AVOGARO, ANGELO/0000-0002-1177-0516;
   Scattolini, Valentina/0000-0002-0855-9402; Ciciliot,
   Stefano/0000-0002-5833-6581; Albiero, Mattia/0000-0003-4142-9738
FU Italian Ministry of University [PRIN 2015ZTT5KB]; Oviesse Co.
FX G.P.F. is the guarantor of this work, and as such, has full access to
   all the data in the study, and takes responsibility for the integrity of
   the data and its accuracy of the data analysis. This work was supported
   by grants from the Italian Ministry of University (PRIN 2015ZTT5KB to
   G.P.F.) and from the Oviesse Co. to the Venetian Institute of Molecular
   Medicine. The authors declare no conflicts of interest.
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NR 29
TC 15
Z9 18
U1 0
U2 13
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
EI 1530-6860
J9 FASEB J
JI Faseb J.
PD JUL
PY 2018
VL 32
IS 7
BP 4004
EP 4015
DI 10.1096/fj.201701409R
PG 12
WC Biochemistry & Molecular Biology; Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GJ2MI
UT WOS:000435104500044
PM 29466053
DA 2025-06-11
ER

PT J
AU Boutzios, G
   Livadas, S
   Piperi, C
   Vitoratos, N
   Adamopoulos, C
   Hassiakos, D
   Iavazzo, C
   Diamanti-Kandarakis, E
AF Boutzios, Georgios
   Livadas, Sarantis
   Piperi, Christina
   Vitoratos, Nicolaos
   Adamopoulos, Christos
   Hassiakos, Dimitrios
   Iavazzo, Christos
   Diamanti-Kandarakis, Evanthia
TI Polycystic ovary syndrome offspring display increased oxidative stress
   markers comparable to gestational diabetes offspring
SO FERTILITY AND STERILITY
LA English
DT Article
DE Oxidative stress; polycystic ovary syndrome; gestational diabetes;
   advanced glycation end products; advanced oxidation protein products
ID GLYCATION END-PRODUCTS; GROWTH-FACTOR-I; CORD-BLOOD; INSULIN-RESISTANCE;
   BIRTH-WEIGHT; CARDIOVASCULAR-DISEASE; LIPID-PEROXIDATION; PREGNANCY
   OUTCOMES; METABOLIC SYNDROME; ENDOTHELIAL-CELLS
AB Objective: To study oxidative stress (OS) markers on neonates. The specific aim was to evaluate advanced glycation end products (AGEs) and advanced oxidation protein products (AOPPs) serum levels along with the hormonal/metabolic profile and their possible relationship in a cohort of polycystic ovary syndrome PCOS(N) and gestational diabetes GDM(N) neonates and their mothers PCOS(M) and GDM(M).
   Design: Prospective controlled study.
   Setting: Academic medical center.
   Patient(s): The study population comprised 151 mother/neonate pairs.
   Intervention(s): Diet and/or insulin administration in GDM(M).
   Main Outcome Measure(s): Anthropometric, metabolic, hormonal parameters, and OS markers.
   Result(s): The AGEs and AOPPs were higher in PCOS(M) and GDM(M) compared with controls (M). The same significant difference was observed in the corresponding groups of neonates. A strong relationship between mothers and neonates regarding AGEs (r = 0.605) and AOPPs levels (r = 0.735) was disclosed. Analogous findings were observed regarding androgens and insulin resistance in mothers and neonates, respectively.
   Conclusion(s): The present study demonstrated that in PCOS(N), the OS status was similar to that of GDM(N) and strongly associated with their mothers' oxidative status. These findings may have clinical implications, as exposure of PCOS(N) to high OS levels during pregnancy could affect several health issues of neonates. (Fertil Steril (R) 2013;99:943-50. (C) 2013 by American Society for Reproductive Medicine.)
C1 [Boutzios, Georgios; Livadas, Sarantis; Diamanti-Kandarakis, Evanthia] Univ Athens, Dept Internal Med 3, Endocrine Unit, Sch Med, Athens 11528, Greece.
   [Piperi, Christina; Adamopoulos, Christos] Univ Athens, Sch Med, Dept Biol Chem, GR-11527 Athens, Greece.
   [Vitoratos, Nicolaos; Hassiakos, Dimitrios; Iavazzo, Christos] Univ Athens, Sch Med, Dept Obstet & Gynecol 2, Aretaie Hosp, GR-11527 Athens, Greece.
C3 National & Kapodistrian University of Athens; Athens Medical School;
   National & Kapodistrian University of Athens; Athens Medical School;
   Athens Medical School; National & Kapodistrian University of Athens
RP Diamanti-Kandarakis, E (corresponding author), Univ Athens, Dept Internal Med 3, Endocrine Unit, Sch Med, 152 Mesogeion St, Athens 11528, Greece.
EM e.diamanti.kandarakis@gmail.com
RI Livadas, Sarantis/D-2668-2014; Iavazzo, Christos/AAN-2565-2020;
   Adamopoulos, Christos/JMQ-6589-2023; Piperi, Christina/AAF-2009-2020
OI Livadas, Sarantis/0000-0001-9594-1521; Adamopoulos,
   Christos/0000-0001-6323-4216; Piperi, Christina/0000-0002-2701-0618
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NR 64
TC 32
Z9 35
U1 0
U2 15
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0015-0282
EI 1556-5653
J9 FERTIL STERIL
JI Fertil. Steril.
PD MAR
PY 2013
VL 99
IS 3
BP 943
EP 950
DI 10.1016/j.fertnstert.2012.10.050
PG 8
WC Obstetrics & Gynecology; Reproductive Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology; Reproductive Biology
GA 098ZZ
UT WOS:000315589300052
PM 23200689
OA Bronze
DA 2025-06-11
ER

PT J
AU Panduru, NM
   Cimponeriu, D
   Cruce, M
   Ion, DA
   Mota, E
   Mota, M
   Serafinceanu, C
   Chivu, LI
   Panduru, M
   Chivu, RD
   Covic, AC
AF Panduru, N. M.
   Cimponeriu, D.
   Cruce, M.
   Ion, Daniela Adriana
   Mota, E.
   Mota, Maria
   Serafinceanu, C.
   Chivu, Laura Ioana
   Panduru, Mihaela
   Chivu, R. D.
   Covic, A. C.
TI Association of+35A/C (intron3/exon3) polymorphism in SOD1-gene with
   diabetic nephropathy in type 1 diabetes
SO ROMANIAN JOURNAL OF MORPHOLOGY AND EMBRYOLOGY
LA English
DT Article
DE SOD1; +35A/C polymorphism; diabetic nephropathy; type 1 diabetes;
   rs2234694
ID SUPEROXIDE-DISMUTASE; INSULIN-RESISTANCE; OXIDATIVE STRESS; METABOLIC
   SYNDROME; MESANGIAL CELLS; PITTSBURGH EPIDEMIOLOGY; GLYCEMIC CONTROL;
   KIDNEY-DISEASE; COMPLICATIONS; EXPRESSION
AB Diabetic nephropathy is a major complication of type 1 diabetes whose pathogenesis is insufficiently known, but oxidative stress and genetic susceptibility seem to be involved. The purpose of this study is to assess the possible association of +35A/C (rs2234694) polymorphism in SOD1-gene with advanced stages of diabetic nephropathy in patients with type 1 diabetes in Romania. There have been enrolled 238 unrelated patients, having type 1 diabetes, divided into group A (106 patients) with diabetic nephropathy - macroalbuminuria or ESRD (End Stage Renal Disease) and group B (132 patients) without diabetic nephropathy. The genomic DNA was extracted from the peripheral venous blood and the genotyping of +35A/C (rs2234694) polymorphism has been made using the PCR-RFLP technique. The statistical analysis has been made using De Finetti's program. There has not been a significant deviation from the Hardy-Weinberg equilibrium for any group (p=0.229 and p=0.894, respectively). The data analysis revealed that the presence of a C-allele confers a significant risk (p=0.008) for the advanced diabetes nephropathy (OR=4.940, 95% C.I.=1.341-18.198), and the CA-genotype (p=0.015) confers a little lower risk (OR=4.491, 95% C.I.=1.203-16.766). This study shows the association of a mutant C-allele of rs2234694 polymorphism in SOD1-gene with the advanced stages of diabetic nephropathy in patients with type 1 diabetes in Romania, suggesting the involvement of the defense against oxidative stress, as an important link in the pathogeny of diabetic nephropathy.
C1 [Panduru, N. M.; Serafinceanu, C.] Nicolae C Paulescu Natl Inst Diabet Nutr & Metab, Bucharest 020475, Romania.
   [Cruce, M.; Mota, E.; Mota, Maria] Univ Med & Pharm Craiova, Craiova, Romania.
   [Cimponeriu, D.] Univ Bucharest, Genet Inst, Bucharest, Romania.
   [Cimponeriu, D.] Carol Davila Univ Med & Pharm, Bucharest, Romania.
   [Ion, Daniela Adriana; Chivu, Laura Ioana; Panduru, Mihaela; Chivu, R. D.] Grigore T Popa Univ Med & Pharm, Iasi, Romania.
C3 University of Medicine & Pharmacy of Craiova; University of Bucharest;
   Carol Davila University of Medicine & Pharmacy; Grigore T Popa
   University of Medicine & Pharmacy
RP Panduru, M (corresponding author), Nicolae C Paulescu Natl Inst Diabet Nutr & Metab, 2nd Diabet Clin,5-7 Ion Movila St, Bucharest 020475, Romania.
EM nicoly_pmn@yahoo.com
RI Covic, Adrian/G-5017-2016; CHIVU, Razvan/ISA-6985-2023; Cimponeriu,
   Danut/AAT-4687-2021; panduru, nicolae/AAB-9885-2021
FU CNCSIS-PNCDI II - RU - TD [66/2007]; PNCDI II - RU - ID [1194/2009]
FX This study was supported by CNCSIS-PNCDI II - RU - TD - No. 66/2007 and
   PNCDI II - RU - ID No. 1194/2009 Grants.
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NR 43
TC 28
Z9 30
U1 1
U2 27
PU EDITURA ACAD ROMANE
PI BUCURESTI
PA CALEA 13 SEPTEMBRIE NR 13, SECTOR 5, BUCURESTI 050711, ROMANIA
SN 1220-0522
J9 ROM J MORPHOL EMBRYO
JI Rom. J. Morphol. Embryol.
PY 2010
VL 51
IS 1
BP 37
EP 41
PG 5
WC Developmental Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Developmental Biology
GA 563WH
UT WOS:000275165700005
PM 20191117
DA 2025-06-11
ER

PT J
AU Dai, YF
   Xu, RJ
   Chen, JX
   Fang, JL
   Zhang, H
   Li, HT
   Chen, W
AF Dai, Yufeng
   Xu, Ruijie
   Chen, Jinxiang
   Fang, Jialong
   Zhang, Hao
   Li, Haitao
   Chen, Wei
TI Thromboxane A2/thromboxane A2 receptor axis facilitates hepatic insulin
   resistance and steatosis through endoplasmic reticulum stress in
   non-alcoholic fatty liver disease
SO BRITISH JOURNAL OF PHARMACOLOGY
LA English
DT Article
DE CaMKII gamma; ER stress; hepatic insulin resistance; NAFLD; TXA2
ID CONCISE GUIDE; ACTIVATION; PATHWAY; TRB3
AB Background and Purpose: Defective insulin signalling and dysfunction of the endoplasmic reticulum (ER), driven by excessive lipid accumulation in the liver, is a characteristic feature in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Thromboxane A(2) (TXA(2)), an arachidonic acid metabolite, is significantly elevated in obesity and plays a crucial role in hepatic gluconeogenesis and adipose tissue macrophage polarization. However, the role of liver TXA(2)/TP receptors in insulin resistance and lipid metabolism is largely unknown.Experimental Approach: TP receptor knockout (TP-/-) mice were generated and fed a high-fat diet for 16 weeks. Insulin sensitivity, ER stress responses and hepatic lipid accumulation were assessed. Furthermore, we used primary hepatocytes to dissect the mechanisms by which the TXA(2)/TP receptor axis regulates insulin signalling and hepatocyte lipogenesis.Key Results: TXA(2) was increased in diet-induced obese mice, and depletion of TP receptors in adult mice improved systemic insulin resistance and hepatic steatosis. Mechanistically, we found that the TXA(2)/TP receptor axis disrupts insulin signalling by activating the Ca2+/calcium calmodulin-dependent kinase II gamma (CaMKII gamma)-protein kinase RNA-like endoplasmic reticulum kinase (PERK)-C/EBP homologous protein (Chop)-tribbles-like protein 3 (TRB3) axis in hepatocytes. In addition, our results revealed that the TXA(2)/TP receptor axis directly promoted lipogenesis in primary hepatocytes and contributed to Kupffer cell inflammation.Conclusions and Implications: The TXA2/TP receptor axis facilitates insulin resistance through Ca2+/CaMKII gamma to activate PERK-Chop-TRB3 signalling. Inhibition of hepatocyte TP receptors improved hepatic steatosis and inflammation. The TP receptor is a new therapeutic target for NAFLD and metabolic syndrome.
C1 [Dai, Yufeng; Xu, Ruijie; Chen, Jinxiang; Fang, Jialong; Zhang, Hao; Li, Haitao; Chen, Wei] Jiangnan Univ, State Key Lab Food Sci & Resources, Wuxi, Jiangsu, Peoples R China.
   [Dai, Yufeng; Xu, Ruijie; Chen, Jinxiang; Fang, Jialong; Zhang, Hao; Li, Haitao; Chen, Wei] Jiangnan Univ, Sch Food Sci & Technol, Wuxi, Jiangsu, Peoples R China.
   [Zhang, Hao; Chen, Wei] Jiangnan Univ, Natl Engn Res Ctr Funct Food, Wuxi, Jiangsu, Peoples R China.
   [Li, Haitao] Jiangnan Univ, Sch Food Sci & Technol, Wuxi 214122, Jiangsu, Peoples R China.
C3 Jiangnan University; Jiangnan University; Jiangnan University; Jiangnan
   University
RP Li, HT (corresponding author), Jiangnan Univ, Sch Food Sci & Technol, Wuxi 214122, Jiangsu, Peoples R China.
EM liht@jiangnan.edu.cn
RI Xu, Ruijie/L-1244-2019; Dai, Yufeng/KBX-4156-2024
OI Li, Haitao/0000-0002-1493-8679; Dai, Yufeng/0000-0002-6598-8203
FU This work was supported by the National Natural Science Foundation of
   China (81773064, 31972973 and 32272290), the National Youth 1000 Talents
   Plan, the Jiangsu Specially-Appointed Professor Program, the Jiangsu
   Province Recruitment Plan for High-level, In [81773064, 31972973,
   32272290]; National Natural Science Foundation of China; National Youth
   1000 Talents Plan; Jiangsu Specially-Appointed Professor Program;
   Jiangsu Province Recruitment Plan for High-level, Innovative and
   Entrepreneurial Talents (Innovative Research Team); Collaborative
   Innovation Center of Food Safety and Quality Control in Jiangsu Province
FX This work was supported by the National Natural Science Foundation of
   China (81773064, 31972973 and 32272290), the National Youth 1000 Talents
   Plan, the Jiangsu Specially-Appointed Professor Program, the Jiangsu
   Province Recruitment Plan for High-level, Innovative and Entrepreneurial
   Talents (Innovative Research Team) and the Collaborative Innovation
   Center of Food Safety and Quality Control in Jiangsu Province.
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U2 18
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0007-1188
EI 1476-5381
J9 BRIT J PHARMACOL
JI Br. J. Pharmacol.
PD APR
PY 2024
VL 181
IS 7
BP 967
EP 986
DI 10.1111/bph.16238
EA NOV 2023
PG 20
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA KR5T3
UT WOS:001101498800001
PM 37940413
DA 2025-06-11
ER

PT J
AU Onyango, AN
AF Onyango, Arnold N.
TI Excessive gluconeogenesis causes the hepatic insulin resistance paradox
   and its sequelae
SO HELIYON
LA English
DT Review
DE Polyol pathway; Hexosamine biosynthetic pathway; Reactive oxygen
   species; Endoplasmic reticulum stress; Reductive stress; Reductive
   carboxylation
ID ENDOPLASMIC-RETICULUM STRESS; FATTY LIVER-DISEASE; STELLATE CELL
   ACTIVATION; DE-NOVO LIPOGENESIS; URIC-ACID; REDUCTIVE CARBOXYLATION;
   GLUTAMINE-METABOLISM; SREBP-1C ACTIVATION; GLUCOSE-PRODUCTION;
   SKELETAL-MUSCLE
AB Background: Hepatic insulin signaling suppresses gluconeogenesis but promotes de novo lipid synthesis. Para-doxically, hepatic insulin resistance (HIR) enhances both gluconeogenesis and de novo lipid synthesis. Elucidation of the etiology of this paradox, which participates in the pathogenesis of non-alcoholic fatty liver disease (NAFLD), cardiovascular disease, the metabolic syndrome and hepatocellular carcinoma, has not been fully achieved. Scope of review: This article briefly outlines the previously proposed hypotheses on the etiology of the HIR paradox. It then discusses literature consistent with an alternative hypothesis that excessive gluconeogenesis, the direct effect of HIR, is responsible for the aberrant lipogenesis. The mechanisms involved therein are explained, involving de novo synthesis of fructose and uric acid, promotion of glutamine anaplerosis, and induction of glucagon resistance. Thus, gluconeogenesis via lipogenesis promotes hepatic steatosis, a component of NAFLD, and dyslipidemia. Gluconeogenesis-centred mechanisms for the progression of NAFLD from simple steatosis to non-alcoholic steatohepatitis (NASH) and fibrosis are suggested. That NAFLD often precedes and predicts type 2 diabetes is explained by the ability of lipogenesis to cushion against blood glucose dysregulation in the earlier stages of NAFLD. Major conclusions: HIR-induced excessive gluconeogenesis is a major cause of the HIR paradox and its sequelae. Such involvement of gluconeogenesis in lipid synthesis rationalizes the fact that several types of antidiabetic drugs ameliorate NAFLD. Thus, dietary, lifestyle and pharmacological targeting of HIR and hepatic gluconeo-genesis may be a most viable approach for the prevention and management of the HIR-associated network of diseases.
C1 [Onyango, Arnold N.] Jomo Kenyatta Univ Agr & Technol, Sch Food & Nutr Sci, POB 62000, Nairobi 00200, Kenya.
C3 Jomo Kenyatta University of Agriculture & Technology
RP Onyango, AN (corresponding author), Jomo Kenyatta Univ Agr & Technol, Sch Food & Nutr Sci, POB 62000, Nairobi 00200, Kenya.
EM arnold.onyango@jkuat.ac.ke
OI Onyango, Arnold/0000-0003-2078-6496
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NR 154
TC 32
Z9 33
U1 4
U2 19
PU CELL PRESS
PI CAMBRIDGE
PA 50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA
EI 2405-8440
J9 HELIYON
JI Heliyon
PD DEC
PY 2022
VL 8
IS 12
AR e12294
DI 10.1016/j.heliyon.2022.e12294
EA DEC 2022
PG 13
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 7J9JM
UT WOS:000904901100003
PM 36582692
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Hameed, A
   Galli, M
   Adamska-Patruno, E
   Kretowski, A
   Ciborowski, M
AF Hameed, Ahsan
   Galli, Mauro
   Adamska-Patruno, Edyta
   Kretowski, Adam
   Ciborowski, Michal
TI Select Polyphenol-Rich Berry Consumption to Defer or Deter Diabetes and
   Diabetes-Related Complications
SO NUTRIENTS
LA English
DT Review
DE berries; metabolic syndrome; precision nutrition; hyperglycemia;
   hyperlipidemia; diabetes; omics; metabolomics; genomics
ID HIGH-FAT-DIET; EUTERPE-OLERACEA MART.; VACCINIUM-VITIS-IDAEA; C-REACTIVE
   PROTEIN; INDUCED OXIDATIVE STRESS; GLUCAGON-LIKE PEPTIDE-1; MORUS-ALBA
   L.; EXTRACT AMELIORATES HYPERGLYCEMIA; CRANBERRY JUICE SUPPLEMENTATION;
   POSTPRANDIAL BLOOD-GLUCOSE
AB Berries are considered "promising functional fruits" due to their distinct and ubiquitous therapeutic contents of anthocyanins, proanthocyanidins, phenolic acids, flavonoids, flavanols, alkaloids, polysaccharides, hydroxycinnamic, ellagic acid derivatives, and organic acids. These polyphenols are part of berries and the human diet, and evidence suggests that their intake is associated with a reduced risk or the reversal of metabolic pathophysiologies related to diabetes, obesity, oxidative stress, inflammation, and hypertension. This work reviewed and summarized both clinical and non-clinical findings that the consumption of berries, berry extracts, purified compounds, juices, jams, jellies, and other berry byproducts aided in the prevention and or otherwise management of type 2 diabetes mellitus (T2DM) and related complications. The integration of berries and berries-derived byproducts into high-carbohydrate (HCD) and high-fat (HFD) diets, also reversed/reduced the HCD/HFD-induced alterations in glucose metabolism-related pathways, and markers of oxidative stress, inflammation, and lipid oxidation in healthy/obese/diabetic subjects. The berry polyphenols also modulate the intestinal microflora ecology by opposing the diabetic and obesity rendered symbolic reduction of Bacteroidetes/Firmicutes ratio, intestinal mucosal barrier dysfunction-restoring bacteria, short-chain fatty acids, and organic acid producing microflora. All studies proposed a number of potential mechanisms of action of respective berry bioactive compounds, although further mechanistic and molecular studies are warranted. The metabolic profiling of each berry is also included to provide up-to-date information regarding the potential anti-oxidative/antidiabetic constituents of each berry.
C1 [Hameed, Ahsan; Adamska-Patruno, Edyta; Kretowski, Adam; Ciborowski, Michal] Med Univ Bialystok, Clin Res Ctr, PL-15089 Bialystok, Poland.
   [Galli, Mauro] Med Univ Bialystok, Dept Med Biol, PL-15222 Bialystok, Poland.
   [Kretowski, Adam] Med Univ Bialystok, Dept Endocrinol Diabetol & Internal Med, PL-15089 Bialystok, Poland.
C3 Medical University of Bialystok; Medical University of Bialystok;
   Medical University of Bialystok
RP Ciborowski, M (corresponding author), Med Univ Bialystok, Clin Res Ctr, PL-15089 Bialystok, Poland.
EM ahsan.hameed@umb.edu.pl; mauro.galli@umb.edu.pl;
   edyta.adamska@umb.edu.pl; adamkretowski@wp.pl;
   michal.ciborowski@umb.edu.pl
RI Galli, Mauro/HCH-5669-2022; Hameed, Ahsan/V-1687-2019; Kretowski,
   Adam/U-6299-2018; Ciborowski, Michal/E-6728-2015; Adamska-Patruno,
   Edyta/L-5788-2018
OI Kretowski, Adam/0000-0002-4522-4978; Galli, Mauro/0000-0003-3871-8125;
   Hameed, Ahsan/0000-0002-9858-2525; Ciborowski,
   Michal/0000-0003-3729-0518; Adamska-Patruno, Edyta/0000-0002-8805-0744
FU European Union's Horizon 2020 Research and Innovation Program under the
   Marie Sklodowska-Curie grant [754432]; Polish Ministry of Science and
   Higher Education; Medical University of Bialystok's strategy of
   excellence project [ANZ-0600-SDUB/2/19]; European Union's Horizon 2020
   Research and Innovation Program [SUB/1/DN/20/009/1196]
FX This research received funding from the European Union's Horizon 2020
   Research and Innovation Program under the Marie Sklodowska-Curie grant
   agreement No. 754432 and the Polish Ministry of Science and Higher
   Education from financial resources for science in 2018-2023 granted for
   the implementation of an international co-financed project. The APC was
   funded by European Union's Horizon 2020 Research and Innovation Program
   (Research project number: SUB/1/DN/20/009/1196) and Medical University
   of Bialystok's strategy of excellence project (Research project number:
   ANZ-0600-SDUB/2/19).
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NR 328
TC 47
Z9 48
U1 5
U2 63
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD SEP
PY 2020
VL 12
IS 9
AR 2538
DI 10.3390/nu12092538
PG 69
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA OE1HC
UT WOS:000580289600001
PM 32825710
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Thibodeau, JF
   Simard, JC
   Holterman, CE
   Blais, A
   Cloutier, MP
   Medeiros, T
   Leduc, M
   Grouix, B
   Leblond, FA
   Burger, D
   Hébert, RL
   Kennedy, CRJ
   Gagnon, L
AF Thibodeau, Jean-Francois
   Simard, Jean-Christophe
   Holterman, Chet E.
   Blais, Amelie
   Cloutier, Marie-Pier
   Medeiros, Thalia
   Leduc, Martin
   Grouix, Brigitte
   Leblond, Francois A.
   Burger, Dylan
   Hebert, Richard L.
   Kennedy, Christopher R. J.
   Gagnon, Lyne
TI PBI-4050 via GPR40 activation improves adenine-induced kidney injury in
   mice
SO CLINICAL SCIENCE
LA English
DT Article
ID ENDOPLASMIC-RETICULUM STRESS; RECEPTOR; MECHANISMS; FIBROSIS; ANEMIA;
   CELLS
AB PBI-4050 (3-pentylbenzenacetic acid sodium salt), a novel first-in-class orally active compound that has completed clinical Phases Ib and II in subjects with chronic kidney disease (CKD) and metabolic syndrome respectively, exerts antifibrotic effects in several organs via a novel mechanism of action, partly through activation of the G protein receptor 40 (GPR40) receptor. Here we evaluate the effects of PBI-4050 in both WT and Gpr40(-/-) mice on adenine-induced tubulointerstitial injury, anemia and activation of the unfolded protein response (UPR) pathway. Adenine-induced CKD was achieved in 8-week-old C57BL/6 mice fed a diet supplemented with 0.25% adenine. After 1 week, PBI-4050 or vehicle was administered daily by oral-gavage for 3 weeks. Gpr40(-/-) mice were also subjected to adenine-feeding, with or without PBI-4050 treatment. PBI-4050 improved renal function and urine concentrating ability. Anemia was present in adenine-fed mice, while PBI-4050 blunted these effects and led to significantly higher plasma erythropoietin (EPO) levels. Adenine-induced renal fibrosis, endoplasmic reticulum (ER) stress and apoptosis were significantly decreased by PBI-4050. In parallel, Gpr40(-/-) mice were more susceptible to adenine-induced fibrosis, renal function impairment, anemia and ER stress compared with WT mice. Importantly, PBI-4050 treatment in Gpr40(-/-) mice failed to reduce renal injury in this model. Taken together, PBI-4050 prevented adenine-induced renal injury while these beneficial effects were lost upon Gpr40 deletion. These data reinforce PBI-4050's use as a renoprotective therapy and identify GPR40 as a crucial mediator of its beneficial effects.
C1 [Thibodeau, Jean-Francois; Holterman, Chet E.; Blais, Amelie; Medeiros, Thalia; Burger, Dylan; Hebert, Richard L.; Kennedy, Christopher R. J.] Ottawa Hosp, Res Inst, Kidney Res Ctr, Ottawa, ON, Canada.
   [Burger, Dylan; Hebert, Richard L.; Kennedy, Christopher R. J.] Univ Ottawa, Fac Med, Dept Cellular & Mol Med, Ottawa, ON, Canada.
   [Thibodeau, Jean-Francois; Simard, Jean-Christophe; Cloutier, Marie-Pier; Leduc, Martin; Grouix, Brigitte; Leblond, Francois A.; Gagnon, Lyne] Promet Biosci Inc, Laval, PQ, Canada.
C3 University of Ottawa; Ottawa Hospital Research Institute; University of
   Ottawa
RP Thibodeau, JF (corresponding author), Ottawa Hosp, Res Inst, Kidney Res Ctr, Ottawa, ON, Canada.; Thibodeau, JF (corresponding author), Promet Biosci Inc, Laval, PQ, Canada.
EM j.thibodeau@prometic.com
RI Burger, Dylan/ABD-2727-2020; Thibodeau, Jean-Francois/AAC-6752-2019;
   Medeiros, Thalia/F-4007-2018
OI Thibodeau, Jean-Francois/0000-0002-9322-4868; Medeiros,
   Thalia/0000-0002-5642-4027; Kennedy, Christopher/0000-0001-5241-860X
FU Prometic BioSciences Inc.; Mitacs Elevate scholarship; Canadian
   Foudnation for Innovation [34468]; CAPES Brazil [88881.187904/2018-1];
   Mitacs Accelerate scholarship
FX This work was supported by Prometic BioSciences Inc., a Mitacs
   Accelerate scholarship (to J.-F.T.); a Mitacs Elevate scholarship (to
   J.-C.S.); a Canadian Foudnation for Innovation grant [grant number 34468
   (to D.B.)] and a CAPES Brazil grant [grant number 88881.187904/2018-1
   (to T.M.)].
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NR 36
TC 10
Z9 13
U1 0
U2 18
PU PORTLAND PRESS LTD
PI LONDON
PA 1ST FLR, 10 QUEEN STREET PLACE, LONDON, ENGLAND
SN 0143-5221
EI 1470-8736
J9 CLIN SCI
JI Clin. Sci.
PD JUL 31
PY 2019
VL 133
IS 14
BP 1587
EP 1602
DI 10.1042/CS20190479
PG 16
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA IM0ZJ
UT WOS:000477717900005
PM 31308217
DA 2025-06-11
ER

PT J
AU Tabrizi, R
   Vakili, S
   Akbari, M
   Mirhosseini, N
   Lankarani, KB
   Rahimi, M
   Mobini, M
   Jafarnejad, S
   Vahedpoor, Z
   Asemi, Z
AF Tabrizi, Reza
   Vakili, Sina
   Akbari, Maryam
   Mirhosseini, Naghmeh
   Lankarani, Kamran B.
   Rahimi, Maryam
   Mobini, Moein
   Jafarnejad, Sadegh
   Vahedpoor, Zahra
   Asemi, Zatollah
TI The effects of curcumin-containing supplements on biomarkers of
   inflammation and oxidative stress: A systematic review and meta-analysis
   of randomized controlled trials
SO PHYTOTHERAPY RESEARCH
LA English
DT Review
DE curcumin; inflammation; meta-analysis; oxidative stress
ID TYPE-2 DIABETES-MELLITUS; METABOLIC SYNDROME; DOUBLE-BLIND; ENDOTHELIAL
   DYSFUNCTION; PLACEBO; MARKERS; ANTIOXIDANT; DISEASE; ACTIVATION;
   PREVENTION
AB Besides other benefits, curcumin is getting more recognized for its antioxidant and anti-inflammatory properties, highlighting the importance of curcumin application for chronic disease prevention. This systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted to assess the influence of curcumin-containing supplements on biomarkers of inflammation and oxidative stress. MEDLINE, EMBASE, Web of Science, and Cochrane Central Register of Controlled Trials were searched till January 2018 for eligible studies. The selected studies were evaluated for their quality using the Cochrane risk of bias tool and relevant data were extracted from included studies. Data were pooled using the inverse variance method and expressed as standardized mean difference (SMD) with 95% confidence intervals (95% CI). Fifteen RCTs were included in the final analysis. The meta-analysis indicated that curcumin supplementation significantly decreased interleukin 6 (IL-6) (SMD -2.08; 95% CI [-3.90, -0.25]; p = 0.02), high-sensitivity C-reactive protein (hs-CRP) (SMD -0.65; 95% CI [-1.20, -0.10], p = 0.02), and malondialdehyde (MDA) concentrations (SMD -3.14; 95% CI [-4.76, -1.53], p < 0.001). Though, curcumin supplementation had no significant effect on tumor necrosis factor-alpha (SMD -1.62; 95% CI [-3.60, 0.36]; p = 0.10) and superoxide dismutase levels (SMD 0.34; 95% CI [-1.06, 1.74], p = 0.63). Overall, this meta-analysis suggests that taking curcumin-containing supplements may exert anti-inflammatory and antioxidant properties through a significant reduction in IL-6, hs-CRP, and MDA levels.
C1 [Tabrizi, Reza; Akbari, Maryam] Shiraz Univ Med Sci, Hlth Policy Res Ctr, Shiraz, Iran.
   [Vakili, Sina] Shiraz Univ Med Sci, Dept Biochem, Shiraz, Iran.
   [Mirhosseini, Naghmeh] Univ Saskatchewan, Sch Publ Hlth, Saskatoon, SK, Canada.
   [Lankarani, Kamran B.] Shiraz Univ Med Sci, Hlth Policy Res Ctr, Shiraz, Iran.
   [Rahimi, Maryam] Iran Univ Med Sci, Sch Med, Dept Gynecol & Obstet, Tehran, Iran.
   [Mobini, Moein] Univ Calgary, Kinesiol Dept, Calgary, AB, Canada.
   [Jafarnejad, Sadegh; Asemi, Zatollah] Kashan Univ Med Sci, Res Ctr Biochem & Nutr Metab Dis, Kashan, Iran.
   [Vahedpoor, Zahra] Kashan Univ Med Sci, Sch Med, Dept Gynecol & Obstet, Kashan, Iran.
C3 Shiraz University of Medical Science; Shiraz University of Medical
   Science; University of Saskatchewan; Shiraz University of Medical
   Science; Iran University of Medical Sciences; University of Calgary
RP Asemi, Z (corresponding author), Kashan Univ Med Sci, Res Ctr Biochem & Nutr Metab Dis, Kashan, Iran.
EM asemi_r@yahoo.com
RI Vakili, Sina/AAW-5684-2021; asemi, zatollah/J-2677-2018; Mirhosseini,
   Naghmeh/AAC-7730-2019; Lankarani, Kamran/P-5336-2019; Akbari,
   Ali/G-6044-2016; Vahedpoor, Zahra/J-9761-2017; Asemi,
   Zatollah/G-7393-2017
OI tabrizi, reza/0000-0001-7634-3948; Asemi, Zatollah/0000-0001-5265-4792;
   Vakili, Sina/0000-0002-5472-8350; Jafarnejad, Sadegh/0000-0002-4666-1918
FU Shiraz University of Medical Sciences; Research, Shiraz University of
   Medical Sciences
FX Shiraz University of Medical Sciences, Grant/Award Number: The current
   study was founded by a grant from the; Research, Shiraz University of
   Medical Sciences
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NR 38
TC 109
Z9 112
U1 2
U2 34
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0951-418X
EI 1099-1573
J9 PHYTOTHER RES
JI Phytother. Res.
PD FEB
PY 2019
VL 33
IS 2
BP 253
EP 262
DI 10.1002/ptr.6226
PG 10
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA HK2MK
UT WOS:000457745900002
PM 30402990
DA 2025-06-11
ER

PT J
AU Leonetti, D
   Soleti, R
   Clere, N
   Vergori, L
   Jacques, C
   Duluc, L
   Dourguia, C
   Martínez, MC
   Andriantsitohaina, R
AF Leonetti, Daniela
   Soleti, Raffaella
   Clere, Nicolas
   Vergori, Luisa
   Jacques, Caroline
   Duluc, Lucie
   Dourguia, Catherine
   Martinez, Maria C.
   Andriantsitohaina, Ramaroson
TI Estrogen Receptor α Participates to the Beneficial Effect of Red Wine
   Polyphenols in a Mouse Model of Obesity-Related Disorders
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Article
DE estrogen receptor alpha; metabolic disorders; obesity; polyphenols;
   vascular disorders
ID ENDOTHELIUM-DEPENDENT VASORELAXATION; ANTHOCYANINS; MECHANISMS; RATS
AB Red wine polyphenol extracts (polyphenols) ameliorate cardiovascular and metabolic disorders associated with obesity. Previously, we demonstrated that the alpha isoform of estrogen receptor (ERa) triggers the vascular protection of polyphenols. Here, we investigated the contribution of ERa on the effects of polyphenols on cardiovascular and metabolic alterations associated with obesity. We used ovariectomized wild type or ERa-deficient mice receiving standard (SD) or western (WD) diets, or SD and WD containing polyphenols (SD+polyphenols and WD+polyphenols, respectively) over a 12-week period. Body weight was measured during treatment. Echocardiography examination was performed before sacrifice. Blood and tissues were sampled for biochemical and functional analysis with respect to nitric oxide (NO center dot) and oxidative stress. Vascular reactivity and liver mitochondrial complexes were analyzed. In WD-fed mice, polyphenols reduced adiposity, plasma triglycerides and oxidative stress in aorta, heart, adipose and liver tissues and enhanced NO center dot production in aorta and liver. ERa deletion prevented or reduced the beneficial effects of polyphenols, especially visceral adiposity, aortic and liver oxidative stresses and NO center dot bioavailability. ERa deletion, however, had no effect on polyphenols ability to decrease the fat accumulation and oxidative stress of subcutaneous adipose tissue. Also, ERa deletion did not modify the decrease of ROS levels induced by polyphenols treatment in the visceral adipose tissue and heart from WD-fed mice. Dietary supplementation of polyphenols remarkably attenuates features of metabolic syndrome; these effects are partially mediated by ERa-dependent mechanisms. This study demonstrates the therapeutic potential of this extract in metabolic and cardiovascular alterations linked to excessive energy intake.
C1 [Leonetti, Daniela; Soleti, Raffaella; Clere, Nicolas; Vergori, Luisa; Jacques, Caroline; Duluc, Lucie; Dourguia, Catherine; Martinez, Maria C.; Andriantsitohaina, Ramaroson] Univ Angers, Stress Oxydant & Pathol Metab, INSERM, U1063, Angers, France.
   [Andriantsitohaina, Ramaroson] CHU Angers, Angers, France.
C3 Universite d'Angers; Institut National de la Sante et de la Recherche
   Medicale (Inserm); Universite d'Angers; Centre Hospitalier Universitaire
   d'Angers
RP Andriantsitohaina, R (corresponding author), Univ Angers, Stress Oxydant & Pathol Metab, INSERM, U1063, Angers, France.; Andriantsitohaina, R (corresponding author), CHU Angers, Angers, France.
EM ramaroson.andriantsitohaina@univ-angers.fr
RI ANDRIANTSITOHAINA, Ramaroson/H-5286-2018; Martinez, Maria
   Carmen/LSJ-1622-2024; Clere, Nicolas/K-4414-2015; SOLETI,
   RAFFAELLA/ABB-5455-2020
OI Duluc, Lucie/0000-0002-5952-8008; andriantsitohaina,
   ramaroson/0000-0002-4770-3585; Clere, Nicolas/0000-0002-6008-597X;
   SOLETI, RAFFAELLA/0000-0002-0271-0490; Martinez, M
   Carmen/0000-0003-3897-7397
FU "OSEO" (bpiFrance)
FX This work was supported by grant of "OSEO" (bpiFrance).
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NR 30
TC 13
Z9 13
U1 0
U2 26
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD JAN 10
PY 2017
VL 7
AR 529
DI 10.3389/fphar.2016.00529
PG 12
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA EG9VI
UT WOS:000391407400001
PM 28119607
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Aller, MA
   de las Heras, N
   Nava, MP
   Regadera, J
   Arias, J
   Lahera, V
AF Aller, Maria-Angeles
   de las Heras, Natalia
   Nava, Maria-Paz
   Regadera, Javier
   Arias, Jaime
   Lahera, Vicente
TI Splanchnic-aortic inflammatory axis in experimental portal hypertension
SO WORLD JOURNAL OF GASTROENTEROLOGY
LA English
DT Review
DE Portal hypertension; Inflammation; Aortopathy; Hepatic steatosis
ID BACTERIAL TRANSLOCATION; MAST-CELLS; NITRIC-OXIDE; GUT MICROBIOTA;
   LIVER; ATHEROSCLEROSIS; RATS; INFILTRATION; MECHANISMS; DISEASES
AB Splanchnic and systemic low-grade inflammation has been proposed to be a consequence of long-term prehepatic portal hypertension. This experimental model causes minimal alternations in the liver, thus making a more selective study possible for the pathological changes characteristic of prehepatic portal hypertension. Low-grade splanchnic inflammation after long-term triple partial portal vein ligation could be associated with liver steatosis and portal hypertensive intestinal vasculopathy. In fact, we have previously shown that prehepatic portal hypertension in the rat induces liver steatosis and changes in lipid and carbohydrate metabolism similar to those produced in chronic inflammatory conditions described in metabolic syndrome in humans. Dysbiosis and bacterial translocation in this experimental model suggest the existence of a portal hypertensive intestinal microbiome implicated in both the splanchnic and systemic alterations related to prehepatic portal hypertension. Among the systemic impairments, aortopathy characterized by oxidative stress, increased levels of proinflammatory cytokines and profibrogenic mediators stand out. In this experimental model of long-term triple portal vein ligated-rats, the abdominal aortic proinflammatory response could be attributed to oxidative stress. Thus, the increased aortic reduced-nicotinamide-adenine dinucleotide phosphate [NAD(P)H] oxidase activity could be associated with reactive oxygen species production and promote aortic inflammation. Also, oxidative stress mediated by NAD(P) H oxidase has been associated with risk factors for inflammation and atherosclerosis. The splanchnic and systemic pathology that is produced in the long term after triple partial portal vein ligation in the rat reinforces the validity of this experimental model to study the chronic low-grade inflammatory response induced by prehepatic portal hypertension. (C) 2013 Baishideng Publishing Group Co., Limited. All rights reserved.
C1 [Aller, Maria-Angeles; Arias, Jaime] Univ Complutense Madrid, Sch Med, Dept Surg, E-28040 Madrid, Spain.
   [de las Heras, Natalia; Lahera, Vicente] Univ Complutense Madrid, Sch Med, Dept Physiol, E-28040 Madrid, Spain.
   [Nava, Maria-Paz] Univ Complutense Madrid, Sch Biol, E-28040 Madrid, Spain.
   [Regadera, Javier] Univ Autonoma Madrid, Sch Med, Dept Histol & Neurosci, Madrid 28046, Spain.
C3 Complutense University of Madrid; Complutense University of Madrid;
   Complutense University of Madrid; Autonomous University of Madrid
RP Aller, MA (corresponding author), Univ Complutense Madrid, Sch Med, Dept Surg, Pza Ramon & Cajal Sn, E-28040 Madrid, Spain.
EM maaller@med.ucm.es
RI ; Aller, Maria Angeles/L-2785-2017; Arias Perez, Jaime/L-2773-2017
OI Lahera, Vicente/0000-0002-9688-4503; Aller, Maria
   Angeles/0000-0002-9232-8446; /0000-0003-0983-8654; Arias Perez,
   Jaime/0000-0003-0182-7790; DE LAS HERAS, NATALIA/0000-0002-2960-6175
FU Mutua Madrilena Medical Research Foundation [AP5966-2009]
FX Supported by Grants from Mutua Madrilena Medical Research Foundation,
   No. AP5966-2009
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NR 51
TC 5
Z9 6
U1 0
U2 16
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 8226 REGENCY DR, PLEASANTON, CA 94588 USA
SN 1007-9327
EI 2219-2840
J9 WORLD J GASTROENTERO
JI World J. Gastroenterol.
PD NOV 28
PY 2013
VL 19
IS 44
BP 7992
EP 7999
DI 10.3748/wjg.v19.i44.7992
PG 8
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 259HZ
UT WOS:000327519300018
PM 24307792
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Flaa, A
   Sandvik, L
   Kjeldsen, SE
   Eide, IK
   Rostrup, M
AF Flaa, Arnljot
   Sandvik, Leiv
   Kjeldsen, Sverre E.
   Eide, Ivar K.
   Rostrup, Morten
TI Does sympathoadrenal activity predict changes in body fat? An 18-y
   follow-up study
SO AMERICAN JOURNAL OF CLINICAL NUTRITION
LA English
DT Article
ID BLOOD-PRESSURE ELEVATION; WEIGHT-GAIN; PLASMA NOREPINEPHRINE;
   ESSENTIAL-HYPERTENSION; SYMPATHETIC ACTIVITY; METABOLIC SYNDROME;
   RISK-FACTORS; YOUNG MEN; OBESITY; THERMOGENESIS
AB Background: Whether alterations in the sympathoadrenal system contribute to obesity or, rather, are consequences of it, is an unresolved issue.
   Objective: We hypothesized that the sympathoadrenal system plays a predictive role in the development of body fat.
   Design: At entry, arterial plasma epinephrine and norepinephrine concentrations were measured in 99 healthy men ((x) over bar +/- SD age: 19.3 +/- 0.4 y) at rest and during a mental stress test and a cold pressor test. Body mass index (BMI; in kg/m(2)), waist circumference, and triceps skinfold thickness were measured at entry and after 18 y of follow-up.
   Results: Eighty subjects (81%) were available for follow-up analyses after a mean (+/- SD) of 18.0 +/- 0.9 y. The epinephrine responses to the mental stress test (E-MST) showed a negative relation to changes in BMI (P = 0.01) and waist circumference (P = 0.007). The mean increase in BMI was 6.3 among subjects in the lowest E,IT quartile and 3.7 in the remaining subjects. In multiple regression analyses corrected for level of exercise, BMI, waist circumference, and triceps skinfold thickness at entry, EMST was found to be a consistent negative predictor of future BMI (P = 0.005), waist circumference (P = 0.00 1), and triceps skinfold thickness (P = 0.05).
   Conclusions: We present the first long-term follow-up study in whites showing that the epinephrine response to mental stress is a negative predictor of future BMI, waist circumference, and triceps skinfold thickness after 18 y of follow-up. These findings may provide further insights into the pathophysiology of obesity.
C1 [Flaa, Arnljot; Rostrup, Morten] Ullevaal Univ Hosp, Cardiovasc & Renale Res Ctr, Dept Acute Med, N-0407 Oslo, Norway.
   [Sandvik, Leiv] Ullevaal Univ Hosp, Clin Res Ctr, Dept Stat, N-0407 Oslo, Norway.
   [Kjeldsen, Sverre E.] Ullevaal Univ Hosp, Dept Cardiol, N-0407 Oslo, Norway.
C3 University of Oslo; University of Oslo; University of Oslo
RP Flaa, A (corresponding author), Ullevaal Univ Hosp, Cardiovasc & Renale Res Ctr, Dept Acute Med, N-0407 Oslo, Norway.
EM amljot.flaa@medisin.uio.no
RI Kjeldsen, Sverre/S-1774-2018
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NR 28
TC 42
Z9 44
U1 0
U2 4
PU AMER SOC CLINICAL NUTRITION
PI BETHESDA
PA 9650 ROCKVILLE PIKE, SUBSCRIPTIONS, RM L-3300, BETHESDA, MD 20814-3998
   USA
SN 0002-9165
J9 AM J CLIN NUTR
JI Am. J. Clin. Nutr.
PD JUN
PY 2008
VL 87
IS 6
BP 1596
EP 1601
DI 10.1093/ajcn/87.6.1596
PG 6
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 313ET
UT WOS:000256724600004
PM 18541545
OA Bronze
DA 2025-06-11
ER

PT J
AU Natorska, J
AF Natorska, Joanna
TI Diabetes mellitus as a risk factor for aortic stenosis: from new
   mechanisms to clinical implications
SO KARDIOLOGIA POLSKA
LA English
DT Review
DE aortic stenosis; diabetes; hyperglycemia; inflammation; risk factors
ID TISSUE FACTOR EXPRESSION; VALVE-REPLACEMENT; METABOLIC SYNDROME;
   OXIDATIVE STRESS; KAPPA-B; TRANSCATHETER; ASSOCIATION; PROGRESSION;
   GLYCATION; RAGE
AB Aortic stenosis (AS) is a progressive disease, with no pharmacological treatment. The prevalence of diabetes mellitus (DM) among AS patients is higher than in the general population. DM significantly increases the risk of AS development and the rate of its progression from mild to severe. However, the mechanism of the interaction between AS and DM is not fully understood. Limited data regarding the influence of hyperglycemia on valvular calcification are available while understanding the cross-talk between them is pivotal in designing an effective therapeutic approach to prevent or at least retard AS development and/or progression in DM patients. Analysis of aortic stenotic valves revealed that increased accumulation of advanced glycoxidation end products (AGEs) was associated with enhanced valvular oxidative stress, inflammation, expression of coagulation factors and markers of calcification. Moreover, AGEs valvular expression correlated with AS severity. Interestingly, in diabetic AS patients, valvular inflammation correlated only with long-term glycemic control parameters, i.e. glycated hemoglobin and fructosamine but not with serum glucose levels. It has been demonstrated that transcatheter aortic valve replacement (TAVI) is beneficial for AS patients also with concomitant DM and safer as compared to surgical aortic valve replacement (SAVR). Moreover, new antidiabetic drugs, such as glucagon-like peptide-1 receptor agonists and sodium-glucose cotransporter-2 inhibitors, targeting inhibition of AGEs-mediated oxidative stress, have been proposed to reduce the risk of AS development in DM patients. This review aimed to comprehensively discuss the impact of DM on AS and its potential therapeutic implications.
C1 [Natorska, Joanna] Jagiellonian Univ Med Coll, Inst Cardiol, Dept Expt Cardiac Surg Anesthesiol & Cardiol, Krakow, Poland.
   [Natorska, Joanna] John Paul 2 Hosp, Krakow Ctr Med Res & Technol, Krakow, Poland.
C3 Jagiellonian University; Collegium Medicum Jagiellonian University
RP Natorska, J (corresponding author), Jagiellonian Univ, Inst Cardiol, Sch Med, Pradnicka 80, PL-31707 Krakow, Poland.
EM joanna.natorska@uj.edu.pl
RI Natorska, Joanna/AHA-6096-2022
FU Polish National Science Centre [UMO-2018/29/B/NZ5/02629]
FX This work was supported by the grant from the Polish National Science
   Centre (UMO-2018/29/B/NZ5/02629 to JN).
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NR 80
TC 21
Z9 21
U1 1
U2 5
PU POLISH CARDIAC SOC
PI WARSZAWA
PA UL STAWKI 3 A LOK 1-2, WARSZAWA, POLAND
SN 0022-9032
EI 1897-4279
J9 KARDIOL POL
JI Kardiol. Pol.
PD OCT 29
PY 2021
VL 79
IS 10
BP 1060
EP 1067
DI 10.33963/KP.a2021.0137
PG 8
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA WP1NB
UT WOS:000712905800003
PM 34643267
OA gold
DA 2025-06-11
ER

PT J
AU Campelj, DG
   Debruin, DA
   Timpani, CA
   Hayes, A
   Goodman, CA
   Rybalka, E
AF Campelj, Dean G.
   Debruin, Danielle A.
   Timpani, Cara A.
   Hayes, Alan
   Goodman, Craig A.
   Rybalka, Emma
TI Sodium nitrate co-supplementation does not exacerbate low dose
   metronomic doxorubicin-induced cachexia in healthy mice
SO SCIENTIFIC REPORTS
LA English
DT Article
ID SKELETAL-MUSCLE; NITRIC-OXIDE; DIETARY NITRATE; INORGANIC NITRATE;
   INDUCED CARDIOMYOPATHY; EXERCISE INTOLERANCE; METABOLIC SYNDROME;
   OXIDATIVE STRESS; CHEMOTHERAPY; DYSFUNCTION
AB The purpose of this study was to determine whether (1) sodium nitrate (SN) treatment progressed or alleviated doxorubicin (DOX)-induced cachexia and muscle wasting; and (2) if a more-clinically relevant low-dose metronomic (LDM) DOX treatment regimen compared to the high dosage bolus commonly used in animal research, was sufficient to induce cachexia in mice. Six-week old male Balb/C mice (n = 16) were treated with three intraperitoneal injections of either vehicle (0.9% NaCl; VEH) or DOX (4 mg/kg) over one week. To test the hypothesis that sodium nitrate treatment could protect against DOX-induced symptomology, a group of mice (n = 8) were treated with 1 mM NaNO3 in drinking water during DOX (4 mg/kg) treatment (DOX + SN). Body composition indices were assessed using echoMRI scanning, whilst physical and metabolic activity were assessed via indirect calorimetry, before and after the treatment regimen. Skeletal and cardiac muscles were excised to investigate histological and molecular parameters. LDM DOX treatment induced cachexia with significant impacts on both body and lean mass, and fatigue/malaise (i.e. it reduced voluntary wheel running and energy expenditure) that was associated with oxidative/nitrostative stress sufficient to induce the molecular cytotoxic stress regulator, nuclear factor erythroid-2-related factor 2 (NRF-2). SN co-treatment afforded no therapeutic potential, nor did it promote the wasting of lean tissue. Our data re-affirm a cardioprotective effect for SN against DOX-induced collagen deposition. In our mouse model, SN protected against LDM DOX-induced cardiac fibrosis but had no effect on cachexia at the conclusion of the regimen.
C1 [Campelj, Dean G.; Debruin, Danielle A.; Timpani, Cara A.; Hayes, Alan; Rybalka, Emma] Victoria Univ, Inst Hlth & Sport, Melbourne, Vic, Australia.
   [Campelj, Dean G.; Debruin, Danielle A.; Timpani, Cara A.; Hayes, Alan; Goodman, Craig A.; Rybalka, Emma] Victoria Univ, Australian Inst Musculoskeletal Sci AIMSS, St Albans, Vic, Australia.
   [Hayes, Alan] Univ Melbourne, Melbourne Med Sch, Dept Med Western Hlth, Melbourne, Vic, Australia.
   [Goodman, Craig A.] Univ Melbourne, Ctr Muscle Res CMR, Dept Physiol, Parkville, Vic, Australia.
C3 Victoria University; Australian Institute for Musculoskeletal Science;
   Victoria University; University of Melbourne; University of Melbourne
RP Rybalka, E (corresponding author), Victoria Univ, Inst Hlth & Sport, Melbourne, Vic, Australia.; Rybalka, E (corresponding author), Victoria Univ, Australian Inst Musculoskeletal Sci AIMSS, St Albans, Vic, Australia.
EM emma.rybalka@vu.edu.au
RI Goodman, Craig/H-8085-2019; Hayes, Alan/M-4231-2014
OI Rybalka, Emma/0000-0002-4854-0036; Campelj, Dean/0000-0003-0259-6920;
   Goodman, Craig/0000-0002-5874-7743; Debruin,
   Danielle/0000-0003-1851-896X; Timpani, Cara/0000-0003-4567-4319
FU Victoria University
FX This study was funded by former Institute of Sport, Exercise and Active
   Living, and Centre for Chronic Disease, program grants (both Victoria
   University).
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NR 82
TC 10
Z9 11
U1 0
U2 2
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD SEP 24
PY 2020
VL 10
IS 1
AR 15044
DI 10.1038/s41598-020-71974-z
PG 17
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA QD3EU
UT WOS:000615406800001
PM 32973229
OA Green Published, Green Accepted, gold
DA 2025-06-11
ER

PT J
AU Bennett, JM
   Marino, JS
   Peck, B
   Roos, LG
   Joseph, KM
   Carter, LB
   Smith, CB
   Rohleder, N
   Coffman, MJ
AF Bennett, J. M.
   Marino, J. S.
   Peck, B.
   Roos, L. G.
   Joseph, K. M.
   Carter, L. B.
   Smith, C. B.
   Rohleder, N.
   Coffman, M. J.
TI Smokers Display Reduced Glucocorticoid Sensitivity Prior to Symptomatic
   Chronic Disease Development
SO ANNALS OF BEHAVIORAL MEDICINE
LA English
DT Article
DE Smoking; Chronic stress; Glucocorticoid sensitivity; Immune function
ID C-REACTIVE PROTEIN; CARDIOVASCULAR RISK-FACTORS; CIGARETTE-SMOKING;
   SOCIOECONOMIC-STATUS; HPA AXIS; NICOTINE DEPENDENCE; METABOLIC SYNDROME;
   ACUTE STRESS; LIFE EVENTS; RESISTANCE
AB Background Chronic stress plays a critical role in many of today's diseases and causes of death. Tobacco use reliably increases the likelihood of chronic disease development and premature death. In addition, habitual tobacco use elevates risk of chronic inflammatory diseases, and glucocorticoid therapy is often less effective in smokers compared with nonsmokers. Taken together, smokers may develop glucocorticoid insensitivity, thereby removing the body's greatest anti-inflammatory mechanism.
   Purpose The purpose of this study was to examine glucocorticoid sensitivity among 24 smokers and 24 age-, sex-, and body mass index-matched never smokers who were clinically healthy individuals (i.e., no diagnosis or medication use for chronic diseases and normotensive).
   Method Participants visited the lab after a 12 hr fast, provided a blood sample, and completed a series of psychosocial questionnaires. Smokers continued smoking ad libitum before the lab visit. Group differences in glucocorticoid sensitivity were examined using ANCOVA and repeated with linear mixed model to account for possible dependence among immune outcomes that matching participants on age, sex, and body mass index may have introduced.
   Results Prior to clinical disease onset, smokers' peripheral blood mononuclear cells (PBMCs) exhibited reduced glucocorticoid sensitivity as well as a diminished inflammatory response to lipopolysaccharide compared with never smokers' PBMCs; results were identical regardless of statistical modeling used.
   Conclusions Cigarette smoking, a self-initiated pharmacological chronic stressor, may provide a unique opportunity to examine early wear and tear on physiological functioning that may lead to chronic disease development. Additional research into PBMCs' intracellular changes must be examined as well as repeating this study in a larger, more heterogeneous population.
C1 [Bennett, J. M.; Joseph, K. M.; Carter, L. B.] UNC Charlotte, Dept Psychol Sci, Charlotte, NC 28223 USA.
   [Bennett, J. M.; Roos, L. G.; Coffman, M. J.] UNC Charlotte, Hlth Psychol PhD Program, Charlotte, NC 28223 USA.
   [Marino, J. S.; Peck, B.] UNC Charlotte, Dept Kinesiol, Lab Syst Physiol, Charlotte, NC 28223 USA.
   [Smith, C. B.; Coffman, M. J.] UNC Charlotte, Sch Nursing, Charlotte, NC 28223 USA.
   [Rohleder, N.] Friedrich Alexander Univ Erlangen Nurnberg, Dept Psychol & Sports Sci, Erlangen, Germany.
   [Rohleder, N.] Brandeis Univ, Dept Psychol, Waltham, MA 02453 USA.
C3 University of North Carolina; University of North Carolina Charlotte;
   University of North Carolina; University of North Carolina Charlotte;
   University of North Carolina; University of North Carolina Charlotte;
   University of North Carolina; University of North Carolina Charlotte;
   University of Erlangen Nuremberg; Brandeis University
RP Bennett, JM (corresponding author), UNC Charlotte, Dept Psychol Sci, Charlotte, NC 28223 USA.; Bennett, JM (corresponding author), UNC Charlotte, Hlth Psychol PhD Program, Charlotte, NC 28223 USA.
EM jbenne70@uncc.edu
RI Marino, Joseph/AGH-6058-2022; Rohleder, Nicolas/N-7598-2013
OI Coffman, Maren/0000-0002-1780-7172; Joseph, Kenya/0000-0003-3037-2203;
   Marino, Joseph/0000-0002-6207-5986
FU University of North Carolina at Charlotte; Faculty Research Grants, I/O
   Masters Program, ARCHES; Department of Psychological Science
FX All work was supported by internal funds awarded via competitive
   opportunities within The University of North Carolina at Charlotte,
   including Faculty Research Grants, I/O Masters Program, ARCHES, and
   Department of Psychological Science. We thank the dedicated assistance
   of past and present StressWAVES BRL research assistants who supported
   the data collection for this project.
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NR 75
TC 2
Z9 2
U1 0
U2 6
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0883-6612
EI 1532-4796
J9 ANN BEHAV MED
JI Ann. Behav. Med.
PD OCT
PY 2018
VL 52
IS 10
BP 830
EP 841
DI 10.1093/abm/kax058
PG 12
WC Psychology, Multidisciplinary
WE Social Science Citation Index (SSCI)
SC Psychology
GA GZ0KT
UT WOS:000449052300002
PM 30212844
DA 2025-06-11
ER

PT J
AU Kovacevic, S
   Nestorov, J
   Matic, G
   Elakovic, I
AF Kovacevic, Sanja
   Nestorov, Jelena
   Matic, Gordana
   Elakovic, Ivana
TI Fructose-enriched diet induces inflammation and reduces antioxidative
   defense in visceral adipose tissue of young female rats
SO EUROPEAN JOURNAL OF NUTRITION
LA English
DT Article
DE Fructose diet; Inflammation; NF-kappa B; Visceral adipose tissue;
   Oxidative stress; Female rats
ID NF-KAPPA-B; TUMOR-NECROSIS-FACTOR; INDUCED INSULIN-RESISTANCE; OXIDATIVE
   STRESS; METABOLIC SYNDROME; TNF-ALPHA; GLUCOCORTICOID-RECEPTOR;
   SWEETENED BEVERAGES; INTERLEUKIN (IL)-1; HEPATIC STEATOSIS
AB The consumption of refined, fructose-enriched food continuously increases and has been linked to development of obesity, especially in young population. Low-grade inflammation and increased oxidative stress have been implicated in the pathogenesis of obesity-related disorders including type 2 diabetes. In this study, we examined alterations in inflammation and antioxidative defense system in the visceral adipose tissue (VAT) of fructose-fed young female rats, and related them to changes in adiposity and insulin sensitivity.
   We examined the effects of 9-week fructose-enriched diet applied immediately after weaning on nuclear factor kappa B (NF-kappa B) intracellular distribution, and on the expression of pro-inflammatory cytokines (IL-1 beta and TNF alpha) and key antioxidative enzymes in the VAT of female rats. Insulin signaling in the VAT was evaluated at the level of insulin receptor substrate-1 (IRS-1) protein and its inhibitory phosphorylation on Ser(307).
   Fructose-fed rats had increased VAT mass along with increased NF-kappa B nuclear accumulation and elevated IL-1 beta, but not TNF alpha expression. The protein levels of antioxidative defense enzymes, mitochondrial manganese superoxide dismutase 2, and glutathione peroxidase, were reduced, while the protein content of IRS-1 and its inhibitory phosphorylation were not altered by fructose diet.
   The results suggest that fructose overconsumption-related alterations in pro-inflammatory markers and antioxidative capacity in the VAT of young female rats can be implicated in the development of adiposity, but do not affect inhibitory phosphorylation of IRS-1.
C1 [Kovacevic, Sanja; Nestorov, Jelena; Matic, Gordana; Elakovic, Ivana] Univ Belgrade, Inst Biol Res Sinisa Stankovic, Dept Biochem, 142 Despot Stefan Blvd, Belgrade 11060, Serbia.
C3 University of Belgrade
RP Elakovic, I (corresponding author), Univ Belgrade, Inst Biol Res Sinisa Stankovic, Dept Biochem, 142 Despot Stefan Blvd, Belgrade 11060, Serbia.
EM ivanae@ibiss.bg.ac.rs
RI Brkljacic, Jelena/JQW-4422-2023; Kovacevic, Sanja/JZC-6964-2024; Matić,
   Gordana/N-7134-2014
OI Brkljacic, Jelena/0000-0003-1978-8646; Kovacevic,
   Sanja/0000-0002-9854-1934
FU Ministry of Education, Science and Technological Development of the
   Republic of Serbia [III41009]
FX Ministry of Education, Science and Technological Development of the
   Republic of Serbia, Grant III41009.
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NR 75
TC 25
Z9 30
U1 0
U2 7
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1436-6207
EI 1436-6215
J9 EUR J NUTR
JI Eur. J. Nutr.
PD FEB
PY 2017
VL 56
IS 1
BP 151
EP 160
DI 10.1007/s00394-015-1065-0
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA EK8IW
UT WOS:000394168100013
PM 26433940
DA 2025-06-11
ER

PT J
AU Priyanka, A
   Anusree, SS
   Nisha, VM
   Raghu, KG
AF Priyanka, Ariyapalli
   Anusree, Sasidharan Suseela
   Nisha, Vijayakumar Marykutty
   Raghu, Kozhiparambil Gopalan
TI Curcumin improves hypoxia induced dysfunctions in 3T3-L1 adipocytes by
   protecting mitochondria and down regulating inflammation
SO BIOFACTORS
LA English
DT Article
DE curcumin; hypoxia; oxidative stress; mitochondrial dysfunctions;
   inflammation
ID OXIDATIVE STRESS; INSULIN-RESISTANCE; OBESITY; EXPRESSION; ADIPOKINES;
   GLUCOSE; IMPACT; OXYGEN; MCT1
AB Obesity induced metabolic syndrome is increasing worldwide at an alarming rate. It is characterized by excessive expansion of white adipose tissue which leads to hypoxia and impairs normal metabolism. Recent studies reveal that hypoxia could be one of the factors for inflammation, insulin resistance and other obesity related complications. There is a high demand for antiobese phytoceuticals to control and manage the complications resulting from obesity. In this study, we investigated how hypoxia affect the physiological functions of 3T3-L1 adipocytes emphasizing on oxidative stress, inflammation, and mitochondrial functions. We also evaluated the protective role of various doses of curcumin, a well-known dietary antioxidant, on hypoxia induced alterations. The results revealed that hypoxia significantly altered the vital parameters of adipocyte biology like HIF 1a expression (103.47% up arrow), lactate, and glycerol release (184.34% and 69.1% up arrow, respectively), reactive oxygen species production (432.53% up arrow), lipid and protein oxidation (376.6% and 566.6% up arrow, respectively), reduction in antioxidant enzymes (superoxide dismutase and catalase) status, secretion of inflammatory markers (TNF alpha, IL 6, IL 1 beta, and IFN gamma), and mitochondrial functions (mitochondrial mass, membrane potential, permeability transition pore integrity, and superoxide generation). Curcumin substantially protected adipocytes from toxic effects of hypoxia in a dose dependent manner by protecting mitochondria and down regulating inflammation. Acriflavine is used as a positive control. A detailed investigation is required for the development of curcumin as an effective nutraceutical against obesity. (C) 2014 BioFactors.
C1 [Priyanka, Ariyapalli; Anusree, Sasidharan Suseela; Nisha, Vijayakumar Marykutty; Raghu, Kozhiparambil Gopalan] CSIR NIIST, Agroproc & Nat Prod Div, Thiruvananthapuram 695019, Kerala, India.
C3 Council of Scientific & Industrial Research (CSIR) - India; CSIR -
   National Institute Interdisciplinary Science & Technology (NIIST)
RP Raghu, KG (corresponding author), CSIR NIIST, Agroproc & Nat Prod Div, Thiruvananthapuram 695019, Kerala, India.
EM raghukgopal2009@gmail.com
RI Raghu, K/AAT-8042-2021
FU University Grants Commission (UGC); CSIR 12th five-year plan project
   "NaPAHA" [CSC0130]
FX Priyanka A thanks University Grants Commission (UGC) for financial
   assistance in the form of research fellowship. The financial support
   from CSIR 12th five-year plan project "NaPAHA (CSC0130)" is
   acknowledged. The authors thank the Director, CSIR-NIIST, for providing
   necessary facilities.
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NR 46
TC 29
Z9 36
U1 1
U2 26
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0951-6433
EI 1872-8081
J9 BIOFACTORS
JI Biofactors
PD SEP-OCT
PY 2014
VL 40
IS 5
BP 513
EP 523
DI 10.1002/biof.1175
PG 11
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA AS6SU
UT WOS:000344393400005
PM 25110893
DA 2025-06-11
ER

PT J
AU Winnik, S
   Gaul, DS
   Preitner, F
   Lohmann, C
   Weber, J
   Miranda, MX
   Liu, YL
   van Tits, LJ
   Mateos, JM
   Brokopp, CE
   Auwerx, J
   Thorens, B
   Lüscher, TF
   Matter, CM
AF Winnik, Stephan
   Gaul, Daniel S.
   Preitner, Frederic
   Lohmann, Christine
   Weber, Julien
   Miranda, Melroy X.
   Liu, Yilei
   van Tits, Lambertus J.
   Mateos, Jose Maria
   Brokopp, Chad E.
   Auwerx, Johan
   Thorens, Bernard
   Luescher, Thomas F.
   Matter, Christian M.
TI Deletion of Sirt3 does not affect atherosclerosis but accelerates weight
   gain and impairs rapid metabolic adaptation in LDL receptor knockout
   mice: implications for cardiovascular risk factor development
SO BASIC RESEARCH IN CARDIOLOGY
LA English
DT Article
DE SIRTUIN 3; Atherosclerosis; Metabolism; Oxidative stress
ID CALORIE RESTRICTION; OXIDATIVE STRESS; MITOCHONDRIAL; DEACETYLATES;
   HOMOLOG; DAMAGE; ACTIVATION; SIRTUINS; TRIGGER; GENE
AB Sirt3 is a mitochondrial NAD(+)-dependent deacetylase that governs mitochondrial metabolism and reactive oxygen species homeostasis. Sirt3 deficiency has been reported to accelerate the development of the metabolic syndrome. However, the role of Sirt3 in atherosclerosis remains enigmatic. We aimed to investigate whether Sirt3 deficiency affects atherosclerosis, plaque vulnerability, and metabolic homeostasis. Low-density lipoprotein receptor knockout (LDLR (-/-)) and LDLR/Sirt3 double-knockout (Sirt3 (-/-) LDLR (-/-)) mice were fed a high-cholesterol diet (1.25 % w/w) for 12 weeks. Atherosclerosis was assessed en face in thoraco-abdominal aortae and in cross sections of aortic roots. Sirt3 deletion led to hepatic mitochondrial protein hyperacetylation. Unexpectedly, though plasma malondialdehyde levels were elevated in Sirt3-deficient mice, Sirt3 deletion affected neither plaque burden nor features of plaque vulnerability (i.e., fibrous cap thickness and necrotic core diameter). Likewise, plaque macrophage and T cell infiltration as well as endothelial activation remained unaltered. Electron microscopy of aortic walls revealed no difference in mitochondrial microarchitecture between both groups. Interestingly, loss of Sirt3 was associated with accelerated weight gain and an impaired capacity to cope with rapid changes in nutrient supply as assessed by indirect calorimetry. Serum lipid levels and glucose tolerance were unaffected by Sirt3 deletion in LDLR (-/-) mice. Sirt3 deficiency does not affect atherosclerosis in LDLR (-/-) mice. However, Sirt3 controls systemic levels of oxidative stress, limits expedited weight gain, and allows rapid metabolic adaptation. Thus, Sirt3 may contribute to postponing cardiovascular risk factor development.
C1 [Winnik, Stephan; Gaul, Daniel S.; Lohmann, Christine; Weber, Julien; Miranda, Melroy X.; Liu, Yilei; van Tits, Lambertus J.; Luescher, Thomas F.; Matter, Christian M.] Univ Zurich Hosp, Dept Med, Div Cardiol, CH-8057 Zurich, Switzerland.
   [Winnik, Stephan; Gaul, Daniel S.; Lohmann, Christine; Weber, Julien; Miranda, Melroy X.; Liu, Yilei; van Tits, Lambertus J.; Luescher, Thomas F.; Matter, Christian M.] Univ Zurich, Inst Physiol, Zurich, Switzerland.
   [Winnik, Stephan] GZO Reg Hlth Ctr Wetzikon, Div Cardiol, Wetzikon, Switzerland.
   [Winnik, Stephan] GZO Reg Hlth Ctr Wetzikon, Dept Med, Wetzikon, Switzerland.
   [Preitner, Frederic; Thorens, Bernard] Univ Lausanne, Ctr Integrat Genom, Lausanne, Switzerland.
   [Miranda, Melroy X.; Auwerx, Johan] Ecole Polytech Fed Lausanne, Sch Life Sci, Lab Integrat Syst Physiol, Lausanne, Switzerland.
   [Mateos, Jose Maria] Univ Zurich, Ctr Microscopy & Image Anal, Zurich, Switzerland.
   [Brokopp, Chad E.] Univ Zurich Hosp, Swiss Ctr Regenerat Med, CH-8057 Zurich, Switzerland.
   [Luescher, Thomas F.; Matter, Christian M.] Univ Zurich, Zurich Ctr Integrat Human Physiol, Zurich, Switzerland.
C3 University of Zurich; University Zurich Hospital; University of Zurich;
   University of Lausanne; Swiss School of Public Health (SSPH+); Swiss
   Federal Institutes of Technology Domain; Ecole Polytechnique Federale de
   Lausanne; University of Zurich; University of Zurich; University Zurich
   Hospital; University of Zurich; Zurich Center Integrative Human
   Physiology (ZIHP)
RP Winnik, S (corresponding author), Univ Zurich Hosp, Dept Med, Div Cardiol, Winterthurerstr 190, CH-8057 Zurich, Switzerland.
EM s.winnik@me.com; christian.matter@uzh.ch
RI Li, Zeyu/GXM-4336-2022; Winnik, Stephan/D-4739-2009; Miranda,
   Melroy/AAN-6437-2021; Auwerx, Johan/ABE-9307-2021
OI Winnik, Stephan/0000-0002-1277-5132; Auwerx, Johan/0000-0002-5065-5393;
   Ziegler, Urs/0000-0001-7860-1867; Mateos, Jose Maria/0000-0002-3675-6198
FU Swiss National Science Foundation, Bern, Switzerland [310030-130626/1,
   310030-118353]; European Research Council [ERC-AdG-231138-sirtuins];
   Swiss Heart Foundation, Bern, Switzerland; Matching Funds; University of
   Zurich, Switzerland; Foundation for Cardiovascular Research, Zurich,
   Switzerland
FX We are grateful to Marianne Carrard for technical assistance in
   biochemical analyses and to Therese Bruggmann for assistance in electron
   microscopy. This study was funded by the Swiss National Science
   Foundation, Bern, Switzerland (310030-130626/1 to C. M. M. and
   310030-118353 to T. F. L.), the European Research Council
   (ERC-AdG-231138-sirtuins to J.A.), the Swiss Heart Foundation, Bern,
   Switzerland (C. M. M.), Matching Funds, University of Zurich,
   Switzerland (C. M. M., S. W., T. F. L.), and the Foundation for
   Cardiovascular Research, Zurich, Switzerland.
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NR 43
TC 52
Z9 58
U1 0
U2 98
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0300-8428
EI 1435-1803
J9 BASIC RES CARDIOL
JI Basic Res. Cardiol.
PD JAN
PY 2014
VL 109
IS 1
AR 399
DI 10.1007/s00395-013-0399-0
PG 15
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 281PQ
UT WOS:000329113900001
PM 24370889
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Jenkins, NT
   Padilla, J
   Boyle, LJ
   Credeur, DP
   Laughlin, MH
   Fadel, PJ
AF Jenkins, Nathan T.
   Padilla, Jaume
   Boyle, Leryn J.
   Credeur, Daniel P.
   Laughlin, M. Harold
   Fadel, Paul J.
TI Disturbed Blood Flow Acutely Induces Activation and Apoptosis of the
   Human Vascular Endothelium
SO HYPERTENSION
LA English
DT Article
DE atherosclerosis; microparticles; shear stress
ID CORONARY-ARTERY-DISEASE; STAGE RENAL-FAILURE; SHEAR RATE PATTERNS; WALL
   SHEAR; CIRCULATING MICROPARTICLES; METABOLIC SYNDROME; RETROGRADE FLOW;
   ATHEROSCLEROSIS; STRESS; DYSFUNCTION
AB There is strong and consistent evidence from in vitro studies that disturbed blood flow produces a proatherogenic vascular endothelial phenotype. However, data from human studies are lacking. To address this, a 220 mm Hg occlusion cuff was placed on the distal forearm of 10 young, healthy men to induce a localized region of disturbed blood flow in the proximal vasculature for 20 minutes. We hypothesized that disturbed blood flow would induce endothelial activation and apoptosis as indicated by increases in local concentrations of CD62E(+) and CD31(+)/CD42b(-) endothelial microparticles, respectively. Distal cuff occlusion induced reductions in mean blood flow, mean shear, and antegrade shear, and increases in retrograde flow, retrograde shear, and oscillatory shear stress, confirming that our protocol produced a disturbed blood flow stimulus in the experimental arm. Relative to baseline (0 minutes), CD62E(+) endothelial microparticles increased by approximate to 3-fold at 10 minutes and approximate to 4-fold at 20 minutes in the experimental arm (P<0.05). CD31(+)/CD42b(-) endothelial microparticles were elevated by approximate to 9-fold at the 20 minutes time point (P<0.05). There were no changes in the concentrations of either endothelial microparticle population throughout the experiment in the contralateral arm, exposed to normal resting blood flow (no cuffs). These findings indicate that disturbed blood flow acutely induces endothelial activation and apoptosis in humans, as reflected by release of microparticles from activated (CD62E(+)) and apoptotic (CD31(+)/CD42b(-)) endothelial cells. These data provide the first in vivo experimental evidence of disturbed blood flow-induced endothelial injury in humans. (Hypertension. 2013;61:615-621.)
C1 [Jenkins, Nathan T.; Padilla, Jaume; Laughlin, M. Harold] Univ Missouri, Dept Biomed Sci, Columbia, MO 65211 USA.
   [Boyle, Leryn J.] Univ Missouri, Dept Nutr & Exercise Physiol, Columbia, MO 65211 USA.
   [Credeur, Daniel P.; Laughlin, M. Harold; Fadel, Paul J.] Univ Missouri, Dept Med Pharmacol & Physiol, Columbia, MO 65211 USA.
   [Laughlin, M. Harold; Fadel, Paul J.] Univ Missouri, Dalton Cardiovasc Res Ctr, Columbia, MO 65211 USA.
C3 University of Missouri System; University of Missouri Columbia;
   University of Missouri System; University of Missouri Columbia;
   University of Missouri System; University of Missouri Columbia;
   University of Missouri System; University of Missouri Columbia
RP Jenkins, NT (corresponding author), Univ Missouri, Dept Biomed Sci, E102 Vet Med Bldg,1600 E Rollins Rd, Columbia, MO 65211 USA.
EM jenkinsnt@missouri.edu
FU National Institutes of Health [T32-AR048523, R01-HL093167]; American
   Heart Association [AHA 11POST5080002]
FX This work was supported by National Institutes of Health grants
   T32-AR048523 (N.T.J. and L.J.B.) and R01-HL093167 (P.J.F.). J.P. was
   supported by a postdoctoral fellowship from the American Heart
   Association (AHA 11POST5080002).
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NR 47
TC 114
Z9 130
U1 0
U2 18
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0194-911X
EI 1524-4563
J9 HYPERTENSION
JI Hypertension
PD MAR
PY 2013
VL 61
IS 3
BP 615
EP 621
DI 10.1161/HYPERTENSIONAHA.111.00561
PG 7
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 089DC
UT WOS:000314888600012
PM 23319545
OA Bronze, Green Accepted
DA 2025-06-11
ER

PT J
AU Casimiro-Lopes, G
   Lisboa, PC
   Koury, JC
   Boaventura, G
   Passos, MCF
   Moura, EG
AF Casimiro-Lopes, G.
   Lisboa, P. C.
   Koury, J. C.
   Boaventura, G.
   Passos, M. C. F.
   Moura, E. G.
TI Maternal Prolactin Inhibition during Lactation Affects Physical
   Performance Evaluated by Acute Exhaustive Swimming Exercise in Adult Rat
   Offspring
SO HORMONE AND METABOLIC RESEARCH
LA English
DT Article
DE programming; exercise performance; oxidative stress; thyroid hormones;
   prolactin
ID OXIDATIVE STRESS; BODY-WEIGHT; THYROID-HORMONES; SKELETAL-MUSCLE;
   LEPTIN; YOUNG; MITOCHONDRIA; HYPOTHYROIDISM; DEHYDROGENASE; MALNUTRITION
AB Maternal prolactin inhibition at the end of lactation programs for metabolic syndrome and hypothyroidism in adult off spring, which could negatively affect exercise performance. We evaluated the effects of maternal hypoprolactinemia in late lactation on physical performance in adult progeny. Lactating Wistar rats were treated with bromocriptine (BRO, 1 mg per day) or saline on days 19, 20, and 21 of lactation and off spring were followed until 180 days old. Physical performance was recorded in untrained rats at 90 and 180 days by an acute exhaustive swimming test (exercise group-Ex). At day 90, BRO off spring showed higher visceral fat mass, higher plasma thiobarbituric acid reactive substances, lower total antioxidant capacity, higher liver glycogen, lower glycemia, and normal insulinemia. Although thyroid hormones (TH) levels were unchanged, mitochondrial glycerol phosphate dehydrogenase (mGPD) activity was lower in muscle and in brown adipose tissue (BAT). At this age, BRO-Ex off spring showed higher exercise capacity, lower blood lactate, higher serum T3, and higher muscle and BAT mGPD activities. At day 180, BRO off spring showed central obesity, hypothyroidism, insulin resistance, and lower EDL (extensor digitorum longus) muscle glycogen with unaltered plasma oxidative stress markers. This group showed no alteration of exercise capacity or blood lactate. After exercise, EDL and liver glycogen were lower, while T3 levels, BAT and muscle mGPD activities were normalized. Liver glycogen seem to be related with higher exercise capacity in younger BRO off spring, while the loss of this temporary advantage maybe related to the hypothyroidism and insulin resistance developed with age.
C1 [Casimiro-Lopes, G.; Lisboa, P. C.; Boaventura, G.; Passos, M. C. F.; Moura, E. G.] Univ Estado Rio de Janeiro, Dept Ciencias Fisiol, Inst Biol Roberto Alcantara Gomes, BR-20551030 Rio De Janeiro, Brazil.
   [Koury, J. C.] Univ Estado Rio de Janeiro, Dept Nutr Basica Expt, Inst Nutr, BR-20551030 Rio De Janeiro, Brazil.
C3 Universidade do Estado do Rio de Janeiro; Universidade do Estado do Rio
   de Janeiro
RP Lisboa, PC (corresponding author), Univ Estado Rio de Janeiro, Dept Ciencias Fisiol, Inst Biol, 5 Andar,Av 28 de Setembro 87, BR-20551030 Rio De Janeiro, Brazil.
EM pclisboa@uerj.br
RI Casimiro-Lopes, Gustavo/C-5502-2008; Koury, Josely/G-8927-2016; Lisboa,
   Patricia/H-8336-2015; Moura, Egberto/H-1270-2012
OI Lisboa, Patricia/0000-0002-2477-4364; Casimiro,
   Gustavo/0000-0002-6329-3918; Moura, Egberto/0000-0002-1159-7549
FU National Council for Scientific and Technological Development (Conselho
   Nacional de Desenvolvimento Cientifico e Tecnologico-CNPq); Coordination
   for the Enhancement of Higher Education Personnel (Coordenacao de
   Aperfeicoamento de Pessoal de Nivel Superior-CAPES); State of Rio de
   Janeiro Carlos Chagas Filho Research Foundation (Fundacao Carlos Chagas
   Filho de Amparo a Pesquisa do Estado do Rio de Janeiro-FAPERJ)
FX The authors are grateful to Miss Monica Moura, Ulisses Risso Siqueira,
   and Carlos Alberto Sampaio Guimaraes for technical assistance. This
   research was supported by National Council for Scientific and
   Technological Development (Conselho Nacional de Desenvolvimento
   Cientifico e Tecnologico-CNPq), Coordination for the Enhancement of
   Higher Education Personnel (Coordenacao de Aperfeicoamento de Pessoal de
   Nivel Superior-CAPES), and State of Rio de Janeiro Carlos Chagas Filho
   Research Foundation (Fundacao Carlos Chagas Filho de Amparo a Pesquisa
   do Estado do Rio de Janeiro-FAPERJ).
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NR 41
TC 6
Z9 6
U1 0
U2 4
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0018-5043
EI 1439-4286
J9 HORM METAB RES
JI Horm. Metab. Res.
PD FEB
PY 2012
VL 44
IS 2
BP 123
EP 129
DI 10.1055/s-0031-1299711
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 894IC
UT WOS:000300419400007
PM 22314333
DA 2025-06-11
ER

PT J
AU Mano, Y
   Anzai, T
   Kaneko, H
   Nagatomo, Y
   Nagai, T
   Anzai, A
   Maekawa, Y
   Takahashi, T
   Meguro, T
   Yoshikawa, T
   Fukuda, K
AF Mano, Yoshinori
   Anzai, Toshihisa
   Kaneko, Hidehiro
   Nagatomo, Yuji
   Nagai, Toshiyuki
   Anzai, Atsushi
   Maekawa, Yuichiro
   Takahashi, Toshiyuki
   Meguro, Tomomi
   Yoshikawa, Tsutomu
   Fukuda, Keiichi
TI Overexpression of Human C-Reactive Protein Exacerbates Left Ventricular
   Remodeling in Diabetic Cardiomyopathy
SO CIRCULATION JOURNAL
LA English
DT Article
DE C-reactive protein; Diabetes mellitus; Heart failure; Inflammation;
   Oxidative stress
ID PRESERVES DIASTOLIC FUNCTION; IMPROVES CARDIAC-FUNCTION;
   RECEPTOR-TYPE-I; HEART-FAILURE; ANGIOTENSIN-II; DILATED CARDIOMYOPATHY;
   NEOINTIMA FORMATION; METABOLIC SYNDROME; INDUCED APOPTOSIS; OXIDATIVE
   STRESS
AB Background: C-reactive protein (CRP) is known to be a pathogenic agent in the cardiovascular system. However, the effect of CRP on heart failure has not been elucidated. The effect of human CRP on cardiac dysfunction induced by diabetes mellitus (DM) using human CRP-overexpressing transgenic mice (CRP-Tg) was examined.
   Methods and Results: DM was induced in male wild-type mice (Wt/DM) and CRP-Tg (CRP/DM) by an injection of streptozotocin. Non-diabetic wild-type mice (Wt/Con) and CRP-Tg (CRP/Con) served as controls. Echocardiography and hemodynamic measurements 6 weeks after injection showed lower fractional shortening and left ventricular (LV) dP/dt max in CRP/DM compared with Wt/DM. Myocardial mRNA levels of interleukin-6, tumor necrosis factor-a, plasminogen activator inhibitor-1, angiotensin type 1 receptor, angiotensinogen, NADPH oxidase subunits (p47(Phox), gp91(phox)) glutathione peroxidase-3. and connective tissue growth factor were increased in CRP/DM compared with Wt/DM. Nuclear staining of 8-hydroxydeoxyguanosine was also increased in CRP/DM compared with Wt/DM. CRP/DM was associated with increased terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling positive cells and a higher ratio of Bax/Bcl-2 proteins compared with Wt/DM. The extent of cardiac fibrosis assessed by Sirius red staining and immunohistochemical staining for collagen type 1 was significantly increased in CRP/DM compared with Wt/DM.
   Conclusions: Overexpression of human CRP exacerbates LV dysfunction and remodeling in diabetic cardiomyopathy, possibly through enhancement of the inflammation, renin-angiotensin system, and oxidative stress. (Circ J 2011;75: 1717-1727)
C1 [Mano, Yoshinori; Anzai, Toshihisa; Kaneko, Hidehiro; Nagatomo, Yuji; Nagai, Toshiyuki; Anzai, Atsushi; Maekawa, Yuichiro; Takahashi, Toshiyuki; Meguro, Tomomi; Yoshikawa, Tsutomu; Fukuda, Keiichi] Keio Univ, Sch Med, Dept Med, Div Cardiol, Tokyo 160, Japan.
C3 Keio University
RP Anzai, T (corresponding author), Int Univ Hlth & Welf, Mita Hosp, Ctr Cardiovasc, Minato Ku, 1-4-3 Mita, Tokyo 1088329, Japan.
EM anzai@cpnet.med.keio.ac.jp
RI Takahashi, Toshiyuki/GWM-4832-2022; Fukuda, Keiichi/L-3777-2013;
   Nagatomo, Yuji/AAQ-1590-2020; Anzai, Toshihisa/J-2179-2015
OI Nagatomo, Yuji/0000-0002-3430-4614; Anzai, Toshihisa/0000-0003-3319-4967
FU Medical School Faculty; Keio University
FX This study was supported by a Medical School Faculty and Alumni Grant
   from Keio University Medical Science Fund (TA.). No potential conflicts
   of interest to this article were reported. We would like to thank Ms
   Hiromi Kato and Ms Mayu Matsuda of Keio University School of Medicine
   for excellent technical assistance.
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NR 58
TC 49
Z9 54
U1 0
U2 11
PU JAPANESE CIRCULATION SOC
PI TOYKO
PA 18TH FLOOR IMPERIAL HOTEL TOWER, 1-1-1 UCHISAIWAI-CHO CHIYODA-KU, TOYKO,
   100-0011, JAPAN
SN 1346-9843
EI 1347-4820
J9 CIRC J
JI Circ. J.
PD JUL
PY 2011
VL 75
IS 7
BP 1717
EP 1727
DI 10.1253/circj.CJ-10-1199
PG 11
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 786YA
UT WOS:000292342600030
PM 21519150
OA Bronze
DA 2025-06-11
ER

PT J
AU Liu, TT
   Shih, KC
   Kao, CC
   Cheng, WT
   Hsieh, PS
AF Liu, Tse-Tsung
   Shih, Kuang-Chung
   Kao, Chung-Cheng
   Cheng, Wei-Tung
   Hsieh, Po-Shiuan
TI Importance of Cyclooxygenase 2-Mediated Low-Grade Inflammation in the
   Development of Fructose-Induced Insulin Resistance in Rats
SO CHINESE JOURNAL OF PHYSIOLOGY
LA English
DT Article
DE cyclooxygenase 2-mediated inflammation; oxidative stress; fructose;
   skeletal muscle; insulin resistance; rats
ID TYPE-2 DIABETES-MELLITUS; GLUCOSE-TRANSPORT; INDUCED HYPERTENSION;
   METABOLIC SYNDROME; OXIDATIVE STRESS; SKELETAL-MUSCLE; PROTEIN;
   INHIBITION; ACTIVATION; BIOSYNTHESIS
AB This study was designed to examine the role of cyclooxygenase (COX) 2-mediated low-grade inflammation in the development of fructose-induced whole body and muscular insulin resistance in rats. The rats were on regular or fructose-enriched diets for 8 weeks. Fructose-fed rats were further divided into 3 groups (n = 8 per group). There were fructose-fed rats, fructose-fed rats with nimesulide (a selective COX2 inhibitor, 30 mg/kg/day, gavage) and fructose-fed rats with celecoxib (a selective COX2 inhibitor, 30 mg/kg/day, gavage). The present result showed that fructose-induced time-dependent increases in systolic blood pressure and fasting plasma insulin and triglyceride levels were significantly suppressed in rats treated with nimesulide or cerecoxib. The ratio of area under glucose curve divided by area tinder insulin curve obtained during the oral glucose tolerance test was significantly decreased in fructose-fed rats, which were markedly reversed in those co-treated with nimesulide or celecoxib. Accordingly, fructose-induced decrease in insulin-stimulated glucose uptake in soleus muscle was significantly reversed in those combined with nimesulide or celecoxib. Fructose-induced time-dependent increases in plasma 8-isoprostane and PGE metabolites were concomitantly suppressed by nimesulide or celecoxib co-treatment. The present study demonstrates that the COX2-mediated low-grade inflammation, especially mediated by increase in oxidative stress was important in the development of insulin resistance in fructose-fed rats.
C1 [Hsieh, Po-Shiuan] Natl Def Med Ctr, Dept Physiol & Biophys, Taipei 114, Taiwan.
   [Liu, Tse-Tsung] Hualien Army Force Hosp, Dept Family & Community, Hualien, Taiwan.
   [Shih, Kuang-Chung] Tri Serv Gen Hosp, Div Endocrinol & Metab, NDMC, Taipei, Taiwan.
   [Kao, Chung-Cheng] Taoyuan Armed Forces Gen Hosp, Dept Emergency, Tao Yuan, Taiwan.
   [Cheng, Wei-Tung] SongShan Armed Forces Gen Hosp, Radiol Sect, Taipei, Taiwan.
C3 National Defense Medical Center; Tri-Service General Hospital
RP Hsieh, PS (corresponding author), Natl Def Med Ctr, Dept Physiol & Biophys, 161 Sect 6 Min Chuan E Rd, Taipei 114, Taiwan.
EM pshsieh@hotmail.com
RI Hsieh, Po-Shiuan/AAF-4173-2020
FU National Science Council of the R.O.C. [NSC94-2320-B-016-021,
   NSC95-2320-B-016012-MY3]
FX The author appreciates the supports from the National Science Council of
   the R.O.C. (grants no. NSC94-2320-B-016-021, and
   NSC95-2320-B-016012-MY3). The author also gratefully acknowledges the
   research assistance of Ms. Yueh-Mei Chung, MS.
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NR 36
TC 12
Z9 14
U1 0
U2 2
PU CHINESE PHYSIOLOGICAL SOC
PI TAIPEI
PA CHINA MEDICAL UNIVERSITY HOSPITAL, UNIV MEDICAL CENTER OF AGING
   RESEARCH, TAIPEI, TAICHUNG 40402, TAIWAN
SN 0304-4920
J9 CHINESE J PHYSIOL
JI Chin. J. Physiol.
PD APR 30
PY 2009
VL 52
IS 2
BP 65
EP 71
DI 10.4077/CJP.2009.AMH034
PG 7
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA 437EJ
UT WOS:000265468800002
PM 19764341
DA 2025-06-11
ER

PT J
AU Adachi, T
   Toishi, T
   Wu, HS
   Kamiya, T
   Hara, H
AF Adachi, Tetsuo
   Toishi, Taisuke
   Wu, Haoshu
   Kamiya, Tetsuro
   Hara, Hirokazu
TI Expression of extracellular superoxide dismutase during adipose
   differentiation in 3T3-L1 cells
SO REDOX REPORT
LA English
DT Article
DE extracellular superoxide dismutase; adipose differentiation; 3T3-L1
   cells
ID OXIDATIVE STRESS; TNF-ALPHA; INSULIN-RESISTANCE; MECHANISM; CYTOKINES;
   PATHWAY; BETA
AB Obesity is known to be the primary causal component in metabolic syndrome. Adipocytes in obese patients exhibit increased oxidative stress via the activation of reactive oxygen species (ROS)-producing systems and inactivation of antioxidant enzymes. Extracellular superoxide dismutase (EC-SOD) is an anti-inflammatory enzyme that protects cells from the damaging effects of ROS. An earlier report showed that plasma EC-SOD levels in type 2 diabetic patients were significantly and inversely related to body mass index and homeostasis model assessment-insulin resistance index. Moreover, the administration of pioglitazone, an antidiabetic agent, significantly increased the plasma level of EC-SOD. In this report, the expression of EC-SOD was compared to other adipocytokines in mice 3T3-L1 pre-adipocytes. EC-SOD expression levels were increased after the induction of differentiation and then declined, which was similar to adiponectin and transcription factors such as peroxisome proliferator-activated receptor-gamma (PPAR-gamma) and CCAAT/enhancer-binding protein-alpha (C/EBP-alpha). On the other hand, the expression levels of pro-inflammatory adipocytokines, such as tumor necrosis factor-alpha (TNF-alpha) and monocyte chemo-attractant protein-1 1 (MCP-1), increased markedly in the development stage of cells. It was observed that the expression of EC-SOD in differentiated 3T3-L1 cells col cultured with LPS-stimulated J774 macrophages was up-regulated, while the addition of TNF-alpha down-regulated EC-SOD and adiponectin expression in adipocytes. It is known that infiltrated and activated macrophages produce extracellular ROS at high levels in adipose tissue. It is possible that the expression of EC-SOD in adipocytes was stimulated to protect them from oxidative stress in the col culture system.
C1 [Adachi, Tetsuo; Toishi, Taisuke; Wu, Haoshu; Kamiya, Tetsuro; Hara, Hirokazu] Gifu Pharmaceut Univ, Lab Clin Pharmaceut, Gifu 5028585, Japan.
C3 Gifu Pharmaceutical University
RP Adachi, T (corresponding author), Gifu Pharmaceut Univ, Lab Clin Pharmaceut, 5-6-1 Mitahora Higashi, Gifu 5028585, Japan.
EM adachi@gifu-pu.ac.jp
RI Kamiya, Tetsuro/AAY-7093-2021
FU Japan Society for the Promotion of Science; Grants-in-Aid for Scientific
   Research [21590169] Funding Source: KAKEN
FX This work was supported, in part, by a Grant-in-Aid for Scientific
   Research from Japan Society for the Promotion of Science (to TA).
CR Adachi T, 2004, REDOX REP, V9, P207, DOI 10.1179/135100004225005985
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   Adachi T, 2001, ATHEROSCLEROSIS, V159, P307, DOI 10.1016/S0021-9150(01)00512-3
   Adachi T, 2006, BIOL PHARM BULL, V29, P2095, DOI 10.1248/bpb.29.2095
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   Evans JL, 2003, DIABETES, V52, P1, DOI 10.2337/diabetes.52.1.1
   Fasshauer M, 2004, BIOCHEM BIOPH RES CO, V317, P598, DOI 10.1016/j.bbrc.2004.03.090
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NR 32
TC 32
Z9 33
U1 0
U2 8
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1351-0002
EI 1743-2928
J9 REDOX REP
JI Redox Rep.
PD FEB
PY 2009
VL 14
IS 1
BP 34
EP 40
DI 10.1179/135100009X392467
PG 7
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 439OO
UT WOS:000265636700005
PM 19161676
OA Bronze
DA 2025-06-11
ER

PT J
AU Subosic, B
   Zdravkovic, V
   Jesic, M
   Munjas, J
   Kovacevic, S
   Guzonjic, A
   Mitrovic, J
   Saso, L
   Duricic, I
   Kotur-Stevuljevic, J
AF Subosic, Branko
   Zdravkovic, Vera
   Jesic, Maja
   Munjas, Jelena
   Kovacevic, Smiljka
   Guzonjic, Azra
   Mitrovic, Jadranka
   Saso, Luciano
   Duricic, Ivana
   Kotur-Stevuljevic, Jelena
TI Childhood obesity accelerates biological ageing: is oxidative stress a
   link?
SO BRITISH JOURNAL OF NUTRITION
LA English
DT Article
DE Childhood obesity; Oxidative stress; Inflammation; Relative leucocyte
   telomere length
ID FATTY LIVER-DISEASE; INSULIN-RESISTANCE; METABOLIC SYNDROME; TELOMERE
   LENGTH; ADIPOSE-TISSUE; LIFE-STYLE; URIC-ACID; INFLAMMATION;
   MACROPHAGES; CHILDREN
AB Obesity is a multifactorial pathophysiological condition with an imbalance in biochemical, immunochemical, redox status and genetic parameters values. We aimed to estimate the connection between relative leucocyte telomere lengths (rLTL) - biomarker of cellular ageing with metabolic and redox status biomarkers values in a group of obese and lean children. The study includes 110 obese and 42 lean children and adolescents, both sexes. The results suggested that rLTL are significantly shorter in obese, compared with lean group (P < 0<middle dot>01). Negative correlation of rLTL with total oxidant status (TOS) (Spearman's rho = -0<middle dot>365, P < 0<middle dot>001) as well as with C-reactive protein (Spearman's rho = -0<middle dot>363, P < 0<middle dot>001) were observed. Principal component analysis (PCA) extracted three distinct factors (i.e. principal components) entitled as: prooxidant factor with 35 % of total variability; antioxidant factor with 30 % of total variability and lipid antioxidant - biological ageing factor with 12 % of the total variability. The most important predictor of BMI > 30 kg/m2 according to logistic regression analysis was PCA-derived antioxidant factor's score (OR: 1<middle dot>66, 95th Cl 1<middle dot>05-2<middle dot>6, P = 0<middle dot>029). PCA analysis confirmed that oxidative stress importance in biological ageing is caused by obesity and its multiple consequences related to prooxidants augmentation and antioxidants exhaustion and gave us clear signs of disturbed cellular homoeostasis deepness, even before any overt disease occurrence.
C1 [Subosic, Branko; Mitrovic, Jadranka] Univ Childrens Hosp, Biochem Lab, Tirsova 10, Belgrade, Serbia.
   [Subosic, Branko; Munjas, Jelena; Guzonjic, Azra; Kotur-Stevuljevic, Jelena] Univ Belgrade, Fac Pharm, Dept Med Biochem, Vojvode Stepe 450, Belgrade 11000, Serbia.
   [Zdravkovic, Vera; Jesic, Maja] Univ Childrens Hosp, Univ Belgrade, Belgrade Sch Med, Dept Endocrinol, Belgrade 11000, Serbia.
   [Zdravkovic, Vera; Jesic, Maja; Kovacevic, Smiljka] Univ Childrens Hosp, Dept Endocrinol, Belgrade 11000, Serbia.
   [Saso, Luciano] Sapienza Univ Rome, Dept Physiol & Pharmacol Vittorio Erspamer, Piazzale Aldo Moro 5, I-00185 Rome, Italy.
   [Duricic, Ivana] Univ Belgrade, Fac Pharm, Dept Bromatol, Vojvode Stepe 450, Belgrade 11000, Serbia.
C3 University of Belgrade; University of Belgrade; University of Belgrade;
   University of Belgrade; Sapienza University Rome; University of Belgrade
RP Subosic, B (corresponding author), Univ Childrens Hosp, Biochem Lab, Tirsova 10, Belgrade, Serbia.; Subosic, B (corresponding author), Univ Belgrade, Fac Pharm, Dept Med Biochem, Vojvode Stepe 450, Belgrade 11000, Serbia.
EM branko.subosic@udk.bg.ac.rs
RI saso, luciano/F-6306-2012
OI saso, luciano/0000-0003-4530-8706
FU Ministry of Education, Science and Technological Development of the
   Republic of Serbia [451-03-68/2020-14/200161]
FX This work was supported by the Ministry of Education, Science and
   Technological Development of the Republic of Serbia,
   451-03-68/2020-14/200161. The authors thank the entire collective of the
   Biochemical Laboratory, University Children's Hospital, and the
   Department of Medical Biochemistry, Faculty of Pharmacy, University of
   Belgrade.
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NR 55
TC 0
Z9 0
U1 0
U2 1
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1145
EI 1475-2662
J9 BRIT J NUTR
JI Br. J. Nutr.
PD JUL 28
PY 2024
VL 132
IS 2
BP 227
EP 235
DI 10.1017/S0007114524000898
EA MAY 2024
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA I2S2K
UT WOS:001284597500001
PM 38736405
OA Bronze
DA 2025-06-11
ER

PT J
AU Leachman, JR
   Cincinelli, C
   Ahmed, N
   Dalmasso, C
   Xu, M
   Gatineau, E
   Nikolajczyk, BS
   Yiannikouris, F
   Hinds, TD
   Loria, AS
AF Leachman, Jacqueline R.
   Cincinelli, Cole
   Ahmed, Nermin
   Dalmasso, Carolina
   Xu, Mei
   Gatineau, Eva
   Nikolajczyk, Barbara S.
   Yiannikouris, Frederique
   Hinds, Terry D., Jr.
   Loria, Analia S.
TI Early life stress exacerbates obesity in adult female mice via
   mineralocorticoid receptor-dependent increases in adipocyte triglyceride
   and glycerol content
SO LIFE SCIENCES
LA English
DT Article
DE Early life stress; Adiposity; Single cell RNA-seq; Lipidomics;
   Spironolactone
ID ADVERSE CHILDHOOD EXPERIENCES; ADIPOSE-TISSUE; PREADIPOCYTE
   DIFFERENTIATION; GLUCOCORTICOID REGULATION; ENDOTHELIAL DYSFUNCTION;
   ALDOSTERONE SECRETION; MATERNAL SEPARATION; COMPUTED-TOMOGRAPHY;
   INSULIN-RESISTANCE; METABOLIC SYNDROME
AB Previously, we have shown that Maternal Separation and Early Weaning (MSEW) exacerbates high fat diet (HF)-induced visceral obesity in female offspring compared to normally reared female mice. Stress hormones such as glucocorticoids and mineralocorticoids are critical mediators in the process of fat expansion, and both can activate the mineralocorticoid receptor (MR) in the adipocyte. Therefore, this study aimed to, comprehend the specific effects of MSEW on adipose tissue basic homeostatic function, and investigate whether female MSEW mice show an exacerbated obesogenic response mediated by MR. Gonadal white adipose tissue (gWAT), a type of visceral fat, was collected to assess lipidomics, transcriptomics, and in vitro lipolysis assay. Obese female MSEW mice showed increased adiposity, elevated 44:2/FA 18:2 + NH4 lipid class and reduced mitochondrial DNA density compared to obese control counterparts. In addition, single-cell RNA sequencing in isolated pre- and mature adipocytes showed a similar to 9-fold downregulation of aquaglycerolporin 3 (Aqp3), a channel responsible for glycerol efflux in adipocytes. Obese MSEW mice showed high levels of circulating aldosterone and gWAT-derived corticosterone compared to controls. Further, the MR blocker spimnolactone (Spiro, 100 mg/kg/day, 2 weeks) normalized the elevated intracellular glycerol levels, the greater in vitro lipolysis response, and the number of large size adipocytes in MSEW mice compared to the controls. Our data suggests that MR plays a role promoting adipocyte hypertrophy in female MSEW mice by preventing lipolysis via glycerol release in favor of triglyceride formation and storage.
C1 [Leachman, Jacqueline R.; Cincinelli, Cole; Ahmed, Nermin; Dalmasso, Carolina; Xu, Mei; Gatineau, Eva; Nikolajczyk, Barbara S.; Yiannikouris, Frederique; Hinds, Terry D., Jr.; Loria, Analia S.] Univ Kentucky, Dept Pharmacol & Nutr Sci, Lexington, KY USA.
   [Loria, Analia S.] Univ Kentucky, SAHA Cardiovasc Ctr, Lexington, KY USA.
   [Nikolajczyk, Barbara S.; Hinds, Terry D., Jr.] Univ Kentucky, Barnstable Brown Diabet Ctr, Coll Med, Lexington, KY USA.
   [Hinds, Terry D., Jr.] Univ Kentucky, Markey Canc Ctr, Lexington, KY USA.
   [Loria, Analia S.] Univ Kentucky, Dept Pharmacol & Nutr Sci, 900 S Limestone St,562 CT Wethington Bldg, Lexington, KY 40536 USA.
C3 University of Kentucky; University of Kentucky; University of Kentucky;
   University of Kentucky; University of Kentucky
RP Loria, AS (corresponding author), Univ Kentucky, Dept Pharmacol & Nutr Sci, 900 S Limestone St,562 CT Wethington Bldg, Lexington, KY 40536 USA.
EM analia.loria@uky.edu
RI Dalmasso, Carolina/LKO-3360-2024; Nikolajczyk, Barbara/AGP-7230-2022;
   Gatineau, Eva/S-7508-2018; Hinds, Terry/B-8495-2015
OI Hinds, Terry/0000-0002-7599-1529; Dalmasso, Carolina/0009-0000-0552-2260
FU National Institutes of Health (NIH) -National Heart, Lung, and Blood
   Institute [R01 HL135158, R01 HL135158-S1]; University of Kentucky Center
   of Research in Obesity and Cardiovascular Disease COBRE [P20 GM103527];
   NIH-National Institute of Diabetes and Digestive and Kidney Diseases
   [1R01DK121797-01A1]
FX This study was supported by funds from the National Institutes of Health
   (NIH) -National Heart, Lung, and Blood Institute R01 HL135158 to ASL,
   R01 HL135158-S1 to JRL, the University of Kentucky Center of Research in
   Obesity and Cardiovascular Disease COBRE P20 GM103527,and the
   NIH-National Institute of Diabetes and Digestive and Kidney Diseases
   grant 1R01DK121797-01A1 to TDHJ and MU.
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NR 100
TC 8
Z9 8
U1 1
U2 9
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0024-3205
EI 1879-0631
J9 LIFE SCI
JI Life Sci.
PD SEP 1
PY 2022
VL 304
AR 120718
DI 10.1016/j.lfs.2022.120718
PG 13
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA 3B7AK
UT WOS:000828088900007
PM 35714704
OA Bronze, Green Accepted
DA 2025-06-11
ER

PT J
AU Nowicki, GJ
   Slusarska, B
   Prystupa, A
   Polak, M
   Czubaj-Kowal, M
   Rudnicka-Drozak, E
AF Nowicki, Grzegorz Jozef
   Slusarska, Barbara
   Prystupa, Andrzej
   Polak, Maciej
   Czubaj-Kowal, Maria
   Rudnicka-Drozak, Ewa
TI Oxidative/Antioxidative Status in Patients after Myocardial Infarction
   and in Those without Cardiovascular Event Depending on Anthropometric
   Factors Defining Body Weight
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Article
DE oxidative status; antioxidant status; oxidative stress; cardiovascular
   diseases; overweight; obesity
ID INDUCED ENDOTHELIAL DYSFUNCTION; OXIDATIVE STRESS MARKERS; INTIMA-MEDIA
   THICKNESS; VISCERAL FAT; RISK-FACTORS; WAIST CIRCUMFERENCE; ANTIOXIDANT
   STATUS; METABOLIC SYNDROME; OBESITY; INFLAMMATION
AB Obesity is one of the factors leading to the development of atherosclerosis. This metabolic disorder is associated with an increased production of reactive oxygen species, which affect the oxidative stress levels. The aim of this study was to evaluate oxidative/antioxidative status and to investigate the correlation between redox markers and anthropometric parameters and body composition in adult patients after myocardial infarction and in individuals without a cardiovascular event in the past. Descriptive data on socio-demographic, clinical, and anthropometric features and blood samples were collected and categorized into two equal groups: after myocardial infarction (study group (SG), n = 80) and without a cardiovascular event (control group (CG), n = 80). The oxidative/antioxidative status was assessed in plasma on the basis of total oxidative/capacitive status (PerOx), total antioxidative status/capacity (ImAnOx), and oxidized low-density lipoprotein (oxLDL). The oxLDL was significantly higher in the CG group compared to the SG group (p = 0.02). No significant differences were found with regard to PerOx and ImAnOx values between the groups studied. A significant positive correlation between PerOx and percentage of adipose tissue (FM%) and body adiposity index (BAI) was found in the two studied groups. ImAnOx significantly positively correlated with visceral adiposity indexes(VAIs) in SG and FM% in CG. OxLDL negatively correlated with body mass index and waist to hip circumference ratio in CG. The total oxidative/antioxidative status is related to the amount of adipose tissue and the BAIs of the subjects. It was observed that it correlates more frequently with the visceral distribution of body fat.
C1 [Nowicki, Grzegorz Jozef; Slusarska, Barbara] Med Univ Lublin, Dept Family Med & Community Nursing, Staszica 6 Str, PL-20081 Lublin, Poland.
   [Prystupa, Andrzej] Med Univ Lublin, Dept Internal Med, Staszica 16 Str, PL-20081 Lublin, Poland.
   [Polak, Maciej] Jagiellonian Univ, Coll Med, Dept Epidemiol & Populat Studies, Grzegorzecka 20 Str, PL-31531 Krakow, Poland.
   [Czubaj-Kowal, Maria] St Zeromski Hosp Cracow, Dept Pediat, Skarpie 66 Str, PL-31913 Krakow, Poland.
   [Rudnicka-Drozak, Ewa] Med Univ Lublin, Dept Family Med, Langiewicza 6A Str, PL-20032 Lublin, Poland.
C3 Medical University of Lublin; Medical University of Lublin; Jagiellonian
   University; Collegium Medicum Jagiellonian University; Medical
   University of Lublin
RP Nowicki, GJ (corresponding author), Med Univ Lublin, Dept Family Med & Community Nursing, Staszica 6 Str, PL-20081 Lublin, Poland.
EM gnowicki84@gmail.com; basiaslusarska@gmail.com; aprystup@wp.pl;
   maciej.1.polak@uj.edu.pl; martacz58@gmail.com; edrozak@poczta.onet.pl
RI Polak, Maciej/T-9960-2018; , Grzegorz/AAS-1947-2020; Slusarska,
   Barbara/U-8951-2018; Stefanadis, Christodoulos/ABH-2232-2020
OI Slusarska, Barbara/0000-0003-0101-9216; Nowicki,
   Grzegorz/0000-0002-0503-8847; Prystupa, Andrzej/0000-0003-4628-8911;
   Rudnicka-Drozak, Ewa/0000-0003-2264-1995; Stefanadis,
   Christodoulos/0000-0001-5974-6454; Czubaj-Kowal,
   Marta/0000-0002-3089-1508
FU Medical University of Lublin [MNmb 615, DS 519]
FX The research was financed from the own resources of the Medical
   University of Lublin as part of the statutory activity in the area of
   maintaining research potential (MNmb 615 and DS 519).
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NR 79
TC 3
Z9 3
U1 0
U2 3
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD NOV
PY 2019
VL 16
IS 21
AR 4077
DI 10.3390/ijerph16214077
PG 16
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA JQ3IF
UT WOS:000498842000023
PM 31652762
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Ilkun, O
   Wilde, N
   Tuinei, J
   Pires, KMP
   Zhu, Y
   Bugger, H
   Soto, J
   Wayment, B
   Olsen, C
   Litwin, SE
   Abel, ED
AF Ilkun, Olesya
   Wilde, Nicole
   Tuinei, Joseph
   Pires, Karla M. P.
   Zhu, Yi
   Bugger, Heiko
   Soto, Jamie
   Wayment, Benjamin
   Olsen, Curtis
   Litwin, Sheldon E.
   Abel, E. Dale
TI Antioxidant treatment normalizes mitochondrial energetics and myocardial
   insulin sensitivity independently of changes in systemic metabolic
   homeostasis in a mouse model of the metabolic syndrome
SO JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
LA English
DT Article
ID FATTY-ACID OXIDATION; DIET-INDUCED OBESITY; DIABETIC AKITA MICE;
   CARDIAC-HYPERTROPHY; SKELETAL-MUSCLE; REACTIVE OXYGEN; ADIPOSE-TISSUE;
   HEART-FAILURE; DYSFUNCTION; PROTEIN
AB Cardiac dysfunction in obesity is associated with mitochondrial dysfunction, oxidative stress and altered insulin sensitivity. Whether oxidative stress directly contributes to myocardial insulin resistance remains to be determined. This study tested the hypothesis that ROS scavenging will improve mitochondrial function and insulin sensitivity in the hearts of rodent models with varying degrees of insulin resistance and hyperglycemia. The catalytic antioxidant MnTBAP was administered to the uncoupling protein-diphtheria toxin A (UCP-DTA) mouse model of insulin resistance (IR) and obesity, at early and late time points in the evolution of IR, and to db/db mice with severe obesity and type-two diabetes. Mitochondrial function was measured in saponin-permeabilized cardiac fibers. Aconitase activity and hydrogen peroxide emission were measured in isolated mitochondria. Insulin-stimulated glucose oxidation, glycolysis and fatty acid oxidation rates were measured in isolated working hearts, and 2-deoxyglucose uptake was measured in isolated cardiomyocytes. Four weeks of MnTBAP attenuated glucose intolerance in 13-week-old UCP-DTA mice but was without effect in 24-week-old UCP-DTA mice and in db/db mice. Despite the absence of improvement in the systemic metabolic milieu, MnTBAP reversed cardiac mitochondrial oxidative stress and improved mitochondria] bioenergetics by increasing ATP generation and reducing mitochondrial uncoupling in all models. MnTBAP also improved myocardial insulin mediated glucose metabolism in 13 and 24-week-old UCP-DTA mice. Pharmacological ROS scavenging improves myocardial energy metabolism and insulin responsiveness in obesity and type 2 diabetes via direct effects that might be independent of changes in systemic metabolism. (C) 2015 Elsevier Ltd. All rights reserved.
C1 [Ilkun, Olesya; Wilde, Nicole; Tuinei, Joseph; Pires, Karla M. P.; Zhu, Yi; Bugger, Heiko; Soto, Jamie; Abel, E. Dale] Univ Utah, Sch Med, Program Mol Med, Div Endocrinol Metab & Diabet, Salt Lake City, UT 84112 USA.
   [Soto, Jamie; Abel, E. Dale] Univ Iowa, Roy J & Lucille A Carver Coll Med, Fraternal Order Eagles Diabet Res Ctr, Div Endocrinol & Metab, Iowa City, IA 52242 USA.
   [Wayment, Benjamin; Olsen, Curtis; Litwin, Sheldon E.] Univ Utah, Sch Med, Div Cardiol, Salt Lake City, UT 84112 USA.
C3 Utah System of Higher Education; University of Utah; University of Iowa;
   Utah System of Higher Education; University of Utah
RP Abel, ED (corresponding author), Univ Iowa, Roy J & Lucille A Carver Coll Med, Fraternal Order Eagles Diabet Res Ctr, Div Endocrinol & Metab, 4312 PBDB,169 Newton Rd, Iowa City, IA 52242 USA.
EM DRCAdmin@uiowa.edu
RI Bugger, Heiko/ABA-4180-2021
OI Bugger, Heiko/0000-0002-3524-0405; Abel, E. Dale/0000-0001-5290-0738;
   Soto, Jamie/0009-0007-9944-681X
FU National Institutes of Health (NIH) [R01HL73167, UO1HL70525]; American
   Diabetes Association; NIH [T32DK091317]; Coordenacao de Aperfeicoamento
   de Pessoal de Nivel Superior (CAPES, Brazil); German Research Foundation
   (DFG)
FX This work was supported by grants R01HL73167 and UO1HL70525 from the
   National Institutes of Health (NIH), and a research grant from the
   American Diabetes Association to E. Dale Abel who is an established
   investigator of the American Heart Association. OI was supported by
   T32DK091317 from the NIH, KMPP by the Coordenacao de Aperfeicoamento de
   Pessoal de Nivel Superior (CAPES, Brazil) and HB by a postdoctoral
   fellowship of the German Research Foundation (DFG).
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NR 50
TC 27
Z9 30
U1 0
U2 17
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0022-2828
EI 1095-8584
J9 J MOL CELL CARDIOL
JI J. Mol. Cell. Cardiol.
PD AUG
PY 2015
VL 85
BP 104
EP 116
DI 10.1016/j.yjmcc.2015.05.012
PG 13
WC Cardiac & Cardiovascular Systems; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Cell Biology
GA CP4UO
UT WOS:000359878300011
PM 26004364
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Kelishadi, R
   Hashemipour, M
   Adeli, K
   Tavakoli, N
   Movahedian-Attar, A
   Shapouri, J
   Poursafa, P
   Rouzbahani, A
AF Kelishadi, Roya
   Hashemipour, Mahin
   Adeli, Khosrow
   Tavakoli, Naser
   Movahedian-Attar, Ahmad
   Shapouri, Javad
   Poursafa, Parinaz
   Rouzbahani, Akbar
TI Effect of Zinc Supplementation on Markers of Insulin Resistance,
   Oxidative Stress, and Inflammation Among Prepubescent Children with
   Metabolic Syndrome
SO METABOLIC SYNDROME AND RELATED DISORDERS
LA English
DT Article
ID LIPID-PEROXIDATION PRODUCTS; RISK; SENSITIVITY; DISEASE; COMPLEX; LEPTIN
AB Objective: This trial aimed to evaluate the effects of zinc sulfate in comparison with placebo on markers of insulin resistance, oxidative stress, and inflammation in a sample of obese prepubescent children.
   Methods: This triple-masked, randomized, placebo-controlled, crossover trial was conducted among 60 obese Iranian children in 2008. Participants were randomly assigned to two groups of equal number; one group received 20 mg of elemental zinc and the other group received placebo on a regular daily basis for 8 weeks. After a 4-week washout period, the groups were crossed over. In addition to anthropometric measures and blood pressure, fasting plasma glucose, lipid profile, insulin, apolipoproteins A-1 (ApoA-I) and B, high-sensitivity C-reactive protein (hs-CRP), leptin, oxidized low-density lipoprotein (ox-LDL), and malondialdehyde were determined at all four stages of the study.
   Results: Irrespective of the order of receiving zinc and placebo, in both groups, significant decrease was documented for Apo B/ApoA-I ratio, ox-LDL, leptin and malondialdehyde, total and LDL-cholesterol after receiving zinc without significant change after receiving placebo. In groups, hs-CRP and markers of insulin resistance decreased significantly after receiving zinc, but increased after receiving placebo. In both groups, the mean body mass index (BMI) Z-score remained high, after receiving zinc, the mean weight, BMI, BMI Z-score decreased significantly, whereas these values increased after receiving placebo.
   Conclusion: These results are particularly important in light of the deleterious consequences of childhood obesity and early changes in markers of inflammatory and oxidative stress. We suggest exploring the direct clinical application of zinc supplementation in childhood obesity in future studies.
C1 [Kelishadi, Roya] Isfahan Univ Med Sci, Pediat Prevent Cardiol Dept, Isfahan Cardiovasc Res Ctr, Esfahan, Iran.
   [Hashemipour, Mahin; Shapouri, Javad] Isfahan Univ Med Sci, Dept Pediat Endocrinol, Isfahan Endocrine & Metab Res Ctr, Esfahan, Iran.
   [Adeli, Khosrow] Univ Toronto, Hosp Sick Children, Dept Clin Biochem, Toronto, ON M5G 1X8, Canada.
   [Tavakoli, Naser; Movahedian-Attar, Ahmad] Isfahan Univ Med Sci, Isfahan Fac Pharm, Dept Pharmaceut, Esfahan, Iran.
   [Poursafa, Parinaz] Sci & Res Univ, Tehran, Iran.
   [Rouzbahani, Akbar] Shahrekord Univ Med Sci, Shahrekord, Iran.
C3 Isfahan University of Medical Sciences; Isfahan University of Medical
   Sciences; University of Toronto; Hospital for Sick Children (SickKids);
   Isfahan University of Medical Sciences; Shahrekord University Medical
   Sciences
RP Kelishadi, R (corresponding author), Isfahan Univ Med Sci, Pediat Prevent Cardiol Dept, Isfahan Cardiovasc Res Ctr, POB 81465-1148, Esfahan, Iran.
EM kroya@aap.net
RI Kelishadi, Roya/E-6154-2012; Tavakoli, Naser/W-1982-2017; Mehrkash,
   Mehryar/D-5317-2018; Poursafa, Parinaz/U-2924-2017
OI Kelishadi, Roya/0000-0001-7455-1495; Shapouri,
   Javad/0000-0003-3767-0668; Adeli, Khosrow/0000-0002-5839-5709; Tavakoli,
   Naser/0000-0003-0654-7675; Mehrkash, Mehryar/0000-0001-6418-5743;
   Poursafa, Parinaz/0000-0002-8067-4122
FU Isfahan University of Medical Sciences, Isfahan, Iran
   [IRCT138808061434N2]
FX This trial was funded by Vice-Chancellery for Research, Isfahan
   University of Medical Sciences, Isfahan, Iran. Trial Registry Unique
   Code: IRCT138808061434N2
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NR 32
TC 109
Z9 116
U1 1
U2 13
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-4196
EI 1557-8518
J9 METAB SYNDR RELAT D
JI Metab. Syndr. Relat. Disord.
PD DEC
PY 2010
VL 8
IS 6
BP 505
EP 510
DI 10.1089/met.2010.0020
PG 6
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 688GN
UT WOS:000284837900007
PM 21028969
DA 2025-06-11
ER

PT J
AU Kopp, W
AF Kopp, Wolfgang
TI Aging and "Age-Related" Diseases-What Is the Relation?
SO AGING AND DISEASE
LA English
DT Article
DE Western diet and smoking; hyperinsulinemia and insulin resistance;
   subclinical inflammation; sympathetic nervous system;
   renin-angiotensin-aldosterone system; oxidative stress and mitochondrial
   dysfunction
ID RENIN-ANGIOTENSIN SYSTEM; BENIGN PROSTATIC HYPERPLASIA;
   SYMPATHETIC-NERVOUS-SYSTEM; FRUCTOSE-INDUCED HYPERTRIGLYCERIDEMIA;
   IMPAIRED GLUCOSE-TOLERANCE; BASAL INSULIN-SECRETION; HIGH-SUCROSE DIET;
   OXIDATIVE STRESS; WESTERN DIET; METABOLIC SYNDROME
AB The study explores the intricate relationship between aging and the development of noncommunicable diseases [NCDs], focusing on whether these diseases are inevitable consequences of aging or primarily driven by lifestyle factors. By examining epidemiological data, particularly from hunter-gatherer societies, the study highlights that many NCDs prevalent in modern populations are rare in these societies, suggesting a significant influence of lifestyle choices. It delves into the mechanisms through which poor diet, smoking, and other lifestyle factors contribute to systemic physiological imbalances, characterized by oxidative stress, insulin resistance and hyperinsulinemia, and dysregulation of the sympathetic nervous system, the renin-angiotensin-aldosterone system, and the immune system. The interplay between this pattern and individual factors such as genetic susceptibility, biological variability, epigenetic changes and the microbiome is proposed to play a crucial role in the development of a range of age-related NCDs. Modified biomolecules such as oxysterols and advanced glycation end products also contribute to their development. Specific diseases such as benign prostatic hyperplasia, Parkinson's disease, glaucoma and osteoarthritis are analyzed to illustrate these mechanisms. The study concludes that while aging contributes to the risk of NCDs, lifestyle factors play a crucial role, offering potential avenues for prevention and intervention through healthier living practices. One possible approach could be to try to restore the physiological balance, e.g. through dietary measures [e.g. Mediterranean diet, Okinawan diet or Paleolithic diet] in conjunction with [a combination of] pharmacological interventions and other lifestyle changes.
C1 [Kopp, Wolfgang] Diagnostikzentrum Graz, Mariatrosterstr 41, A-8043 Graz, Austria.
RP Kopp, W (corresponding author), Mariatrosterstr 41, A-8043 Graz, Austria.
EM koppwolf02@gmail.com
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NR 358
TC 4
Z9 4
U1 17
U2 47
PU INT SOC AGING & DISEASE
PI FORT WORTH
PA EDITORIAL OFF, 3400 CAMP BOWIE BLVD, FORT WORTH, TX 76106 USA
SN 2152-5250
J9 AGING DIS
JI Aging Dis.
PD JUN
PY 2025
VL 16
IS 3
BP 1316
EP 1346
DI 10.14336/AD.2024.0570
PG 31
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA 3EY6R
UT WOS:001498736400008
PM 39012663
OA gold
DA 2025-06-11
ER

PT J
AU Liang, L
   Zheng, YG
   Xie, YP
   Xiao, L
   Wang, GH
AF Liang, Liang
   Zheng, Yage
   Xie, Yinping
   Xiao, Ling
   Wang, Gaohua
TI Oridonin ameliorates insulin resistance partially through inhibition of
   inflammatory response in rats subjected to chronic unpredictable mild
   stress
SO INTERNATIONAL IMMUNOPHARMACOLOGY
LA English
DT Article
DE Insulin resistance; NLRP3 inflammasome; NEK7; Oridonin; Inflammation
ID DEPRESSIVE SYMPTOMS; METABOLIC SYNDROME; NLRP3 ACTIVATION; RISK;
   ANTAGONIST; EFFICACY; OBESITY; NEK7
AB Background: Oridonin (Ori) has multiple biological properties, especially anti-inflammatory. However, its effects on chronic unpredictable mild stress (CUMS)-induced insulin resistance are still unclear. In this study, we explored the regulatory role of Ori in CUMS-triggered insulin resistance, and the underlying molecular mechanisms; Methods: SD rats were subjected to CUMS for 4 weeks, some of which were injected with Ori or fluoxetine (FLX) in durations of CUMS. After CUMS procedure, the behavioral and metabolic tests were performed. Elisa, immunofluorescence and western blotting were used to determine the inflammatory response and NLRP3 inflammasome activation. We investigated the interaction between NLRP3 and NEK7 using immunoprecipitation. Finally, we detected the proinflammatory cytokines in Lipopolysaccharide (LPS)-activated RAW264.7 cells treated with Ori;
   Results: In this study, we found that chronic stress resulted in depressive-like behavior comorbid with insulin resistance. Ori was discovered to ameliorate insulin resistance as well as insulin signaling disturbance in the hippocampus. In addition, CUMS caused the infiltration of macrophages into the islets. And IL-113, IL-18 and caspase-1 were elevated in pancreases of CUMS rats, which could also be reversed by Ori treatment via reducing the interaction between NLRP3 and NEK7. Furthermore, Ori dose-dependently inhibited the levels of IL-113 and IL-18 in LPS-activated RAW264.7 cells;
   Conclusions: All these results supported our hypothesis that Ori possesses potent anti-insulin resistant actions, which is partially correlated with inhibiting infiltration of macrophages into the islets and NLRP3 activation induced by CUMS. Therefore, our results highlighted the protective role of Ori against CUMS-elicited insulin resistance.
C1 [Liang, Liang; Zheng, Yage; Xie, Yinping; Xiao, Ling; Wang, Gaohua] Wuhan Univ, Renmin Hosp, Dept Psychiat, Wuhan 430060, Peoples R China.
C3 Wuhan University
RP Wang, GH (corresponding author), Wuhan Univ, Renmin Hosp, Dept Psychiat, Wuhan 430060, Peoples R China.
EM wgh6402@163.com
FU National Natural Science Foundation of China [81571325, 81401117]
FX Thanks to Dr. Gaohua Wang for the financial support. This study was
   supported by the National Natural Science Foundation of China
   (No.81571325 and NO.81401117).
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VL 91
AR 107298
DI 10.1016/j.intimp.2020.107298
PG 13
WC Immunology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Pharmacology & Pharmacy
GA QB1SE
UT WOS:000613922300002
PM 33388733
DA 2025-06-11
ER

PT J
AU de la Garza, AL
   Etxeberria, U
   Haslberger, A
   Aumueller, E
   Martínez, JA
   Milagro, FI
AF Laura de la Garza, Ana
   Etxeberria, Usune
   Haslberger, Alexander
   Aumueller, Eva
   Alfredo Martinez, J.
   Milagro, Fermin I.
TI Helichrysum and Grapefruit Extracts Boost Weight Loss in Overweight Rats
   Reducing Inflammation
SO JOURNAL OF MEDICINAL FOOD
LA English
DT Article
DE flavonoids; grapefruit; helichrysum; insulin resistance; TLR2; TNF
ID INSULIN-RESISTANCE; OXIDATIVE STRESS; REGULATING ENZYMES; METABOLIC
   SYNDROME; NARINGIN; OBESITY; ADIPONECTIN; MECHANISMS; EXPRESSION;
   FLAVONOIDS
AB Obesity is characterized by an increased production of inflammatory markers. High levels of circulating free fatty acids and chronic inflammation lead to increased oxidative stress, contributing to the development of insulin resistance (IR). Recent studies have focused on the potential use of flavonoids for obesity management due to their antioxidant and anti-inflammatory properties. This study was designed to investigate the antioxidant and anti-inflammatory effects of helichrysum and grapefruit extracts in overweight insulin-resistant rats. Thirty-eight male Wistar rats were randomly distributed in two groups: control group (n=8) and high-fat sucrose (HFS) group (n=30). After 22 days of ad libitum water and food access, the rats fed HFS diet changed to standard diet and were reassigned into three groups (n=10 each group): nonsupplemented, helichrysum extract (2g/kg bw), and grapefruit extract (1g/kg bw) administered for 5 weeks. Rats supplemented with both extracts gained less body weight during the 5-week period of treatment, showed lower serum insulin levels and liver TBARS levels. Leptin/adiponectin ratio, as an indicator of IR, was lower in both extract-administered groups. These results were accompanied by a reduction in TNF gene expression in epididymal adipose tissue and intestinal mucosa, and TLR2 expression in intestinal mucosa. Helichrysum and grapefruit extracts might be used as complement hypocaloric diets in weight loss treatment. Both extracts helped to reduce weight gain, hyperinsulinemia, and IR, improved inflammation markers, and decreased the HFS diet-induced oxidative stress in insulin-resistant rats.
C1 [Laura de la Garza, Ana; Etxeberria, Usune; Alfredo Martinez, J.; Milagro, Fermin I.] Univ Navarra, Dept Nutr Food Sci & Physiol, E-31080 Pamplona, Spain.
   [Laura de la Garza, Ana; Etxeberria, Usune; Alfredo Martinez, J.; Milagro, Fermin I.] Univ Navarra, Fac Pharm, Ctr Nutr Res, Pamplona, Spain.
   [Haslberger, Alexander; Aumueller, Eva] Univ Vienna, Dept Nutr Sci, Vienna, Austria.
   [Alfredo Martinez, J.; Milagro, Fermin I.] Carlos III Hlth Res Inst, CIBERobn, Physiopathol Obes & Nutr, Madrid, Spain.
C3 University of Navarra; University of Navarra; University of Vienna;
   CIBER - Centro de Investigacion Biomedica en Red; CIBEROBN
RP Martínez, JA (corresponding author), Univ Navarra, Dept Nutr Food Sci & Physiol, C Irunlarrea 1, Navarra 31008, Spain.
EM jalfmtz@unav.es
RI Haslberger, Alexander/B-9120-2013; Aranburu, Usune/ABG-9510-2020;
   Milagro, Fermin/F-2315-2015; Martínez, J./K-8709-2014; de la Garza, Ana
   Laura/GLU-6360-2022
OI Haslberger, Alexander/0000-0001-9699-537X; Milagro, Fermin
   I./0000-0002-3228-9916; Etxeberria, Usune/0000-0001-9554-0015; de la
   Garza, Ana Laura/0000-0002-6049-903X
FU Center for Industrial Technological Development (CDTI, initiative
   INGENIO, Spain); "Asociacion de Amigos" of the University of Navarra;
   Department of Education, Universities and Research of Basque Government
FX We thank Linea Especial (LE/97) from the University of Navarra (Spain),
   CIBERobn from Madrid (Spain) and Biosearch S.A. within the framework of
   the CENIT PRO-NAOS Program granted by the Center for Industrial
   Technological Development (CDTI, initiative INGENIO 2010, Spain). We
   also thank "Asociacion de Amigos" of the University of Navarra for the
   predoctoral grant given to A.L. de la Garza. U. Etxeberria holds a
   predoctoral grant from the Department of Education, Universities and
   Research of Basque Government.
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NR 39
TC 18
Z9 19
U1 0
U2 23
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1096-620X
EI 1557-7600
J9 J MED FOOD
JI J. Med. Food
PD AUG 1
PY 2015
VL 18
IS 8
BP 890
EP 898
DI 10.1089/jmf.2014.0088
PG 9
WC Chemistry, Medicinal; Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Food Science & Technology; Nutrition &
   Dietetics
GA CS4YM
UT WOS:000362082300008
PM 25599391
DA 2025-06-11
ER

PT J
AU Navarro-Alarcón, M
   Ruiz-Ojeda, FJ
   Blanca-Herrera, RM
   A-Serrano, MM
   Acuña-Castroviejo, D
   Fernández-Vázquez, G
   Agil, A
AF Navarro-Alarcon, Miguel
   Ruiz-Ojeda, Francisco J.
   Blanca-Herrera, Rosa M.
   A-Serrano, Maria Mohammad
   Acuna-Castroviejo, Dario
   Fernandez-Vazquez, Gumersindo
   Agil, Ahmad
TI Melatonin and metabolic regulation: a review
SO FOOD & FUNCTION
LA English
DT Review
ID DIABETIC FATTY RATS; SPONTANEOUSLY HYPERTENSIVE-RATS; INDUCED OXIDATIVE
   STRESS; CENTRAL MELANOCORTIN SYSTEM; FOCAL CEREBRAL-ISCHEMIA; REDUCES
   BLOOD-PRESSURE; NITRIC-OXIDE SYNTHASE; BROWN ADIPOSE-TISSUE;
   DIET-INDUCED OBESITY; BODY-WEIGHT
AB Human life expectancy has increased over the past 50 years due to scientific and medical advances and higher food availability. However, overweight and obesity affect more than 50% of adults and 15% of infants and adolescents. There has also been a marked increase in the prevalence of metabolic syndrome in recent decades, which has been associated with a reduction in nocturnal pineal production of melatonin with aging and an increased risk of coronary diseases, type 2 diabetes mellitus (T2DM) and death. Melatonin is currently under intensive investigation in experimental animal models of diabetes, obesity and MS at pharmacological doses (between 5 and 20 mg kg(-1) body weight), demonstrating its capacity to ameliorate the total metabolic profile and its potential as an alternative to conventional drug therapies for the disorders associated with the MS, i.e. elevated systolic blood pressure, and impairment of glucose homeostasis, plasma lipid profile, inflammation, oxidative stress, and increased body weight. An especially significant finding is the induction by melatonin of white adipose tissue browning, which may be related to its effects against oxidative stress, uncoupling the mitochondrial bioenergetic process by enhancing the expression of uncoupled-protein-1 (UCP-1), which has been related to body weight reduction in experimental animals. Further research is required to improve knowledge of this mechanism. Clinical studies are needed with the administration of pharmacological melatonin doses, because the dose has ranged between 0.050 and 0.16 mg kg(-1) bw in most studies to date. Melatonin is a natural phytochemical, and it is also important to test its beneficial metabolic effects when consumed in functional foods.
C1 [Navarro-Alarcon, Miguel; Ruiz-Ojeda, Francisco J.; Blanca-Herrera, Rosa M.] Univ Granada, Fac Pharm, Dept Nutr & Food Chem, E-18071 Granada, Spain.
   [A-Serrano, Maria Mohammad; Agil, Ahmad] Univ Granada, Sch Med, Dept Pharmacol, Inst Neurosci, E-18071 Granada, Spain.
   [Acuna-Castroviejo, Dario] Univ Granada, Sch Med, Dept Pharmacol, Inst Biotechnol, E-18071 Granada, Spain.
   [Fernandez-Vazquez, Gumersindo] Carlos III Hosp, Serv Endocrinol, Madrid, Spain.
   [Agil, Ahmad] King Abdulaziz Univ, Fac Med, Dept Pharmacol, Jeddah, Saudi Arabia.
C3 University of Granada; University of Granada; University of Granada;
   Hospital Carlos III; King Abdulaziz University
RP Navarro-Alarcón, M (corresponding author), Univ Granada, Fac Pharm, Dept Nutr & Food Chem, E-18071 Granada, Spain.
EM nalarcon@ugr.es; aagil@ugr.es
RI Agil, Ahmad/D-9620-2014; Vázquez, Gumersindo/AAB-3317-2019;
   Navarro-Alarcon, Miguel/Q-4368-2019; Ruiz Ojeda, Francisco
   Javier/D-1228-2016; Acuna-Castroviejo, Dario/N-7456-2016;
   Navarro-Alarcon, Miguel/K-6646-2014
OI Ruiz Ojeda, Francisco Javier/0000-0002-4452-0855; Acuna-Castroviejo,
   Dario/0000-0002-9680-1560; Agil, Ahmad/0000-0003-0164-9648;
   Navarro-Alarcon, Miguel/0000-0002-3189-3310
FU Marco de Campus de Excelencia Internacional Proyecto Granada Research of
   Excelence Initiative on BioHealth (GREIB); Subprograma GREIB
   Translational Projects, Vicerrectorado de Politica Cientifica e
   Investigacion, Universidad de Granada; Ministerio de Economia y
   Competitividad (Spain) [SAF 2013-45752-R]; Junta de Andalucia (Spain)
   [AGR-141, CTS-109]
FX This work was partially supported by grants Marco de Campus de
   Excelencia Internacional Proyecto Granada Research of Excelence
   Initiative on BioHealth (GREIB), Subprograma GREIB Translational
   Projects, Vicerrectorado de Politica Cientifica e Investigacion,
   Universidad de Granada (2011), SAF 2013-45752-R from the Ministerio de
   Economia y Competitividad (Spain), and AGR-141 and CTS-109 groups from
   the Junta de Andalucia (Spain).
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NR 218
TC 62
Z9 63
U1 2
U2 61
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PD NOV
PY 2014
VL 5
IS 11
BP 2806
EP 2832
DI 10.1039/c4fo00317a
PG 27
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA AS5OT
UT WOS:000344320600013
PM 25207999
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Lien, LM
   Chiou, HY
   Yeh, HL
   Chiu, SY
   Jeng, JS
   Lin, HJ
   Hu, CJ
   Hsieh, FI
   Wei, YH
AF Lien, Li-Ming
   Chiou, Hung-Yi
   Yeh, Hsu-Ling
   Chiu, Shang-Yen
   Jeng, Jiann-Shing
   Lin, Huey-Juan
   Hu, Chaur-Jong
   Hsieh, Fang-I
   Wei, Yau-Huei
TI Significant Association Between Low Mitochondrial DNA Content in
   Peripheral Blood Leukocytes and Ischemic Stroke
SO JOURNAL OF THE AMERICAN HEART ASSOCIATION
LA English
DT Article
DE association study; ischemic stroke; mitochondrial DNA content
ID OXIDATIVE STRESS; COPY NUMBER; DYSFUNCTION; DAMAGE; RISK;
   ATHEROSCLEROSIS; BIOGENESIS; VARIANTS; SEQUENCE; DISEASE
AB Background-Cumulative evidence has shown that low mitochondrial DNA ( mtDNA) content is related to elevated oxidative stress and atherosclerosis, which play important roles in ischemic stroke. The objective of this study was to explore the association between mtDNA content in peripheral blood leukocytes and ischemic stroke.
   Methods and Results-A total of 350 patients with first-ever ischemic stroke and 350 healthy controls were recruited in this case-control study. The mtDNA content in peripheral blood leukocytes was determined by quantitative real-time polymerase chain reaction. The levels of oxidized glutathione, reduced glutathione, and 8-hydroxy-20-deoxyguanosine were measured by ELISA kits. Multivariate logistic regression models were used to analyze the relationship between mtDNA content in peripheral blood leukocytes and ischemic stroke. Our results show that mtDNA content of patients with ischemic stroke was notably lower compared with controls. A significant association was found between low mtDNA content and ischemic stroke. Furthermore, significant interactions were identified between low mtDNA and proven risk factors in patients with ischemic stroke. The levels of oxidized glutathione and 8-hydroxy-20-deoxyguanosine were significantly greater in patients with ischemic stroke compared with controls.
   Conclusions-Our results demonstrate that low mtDNA content in peripheral blood leukocytes is associated with ischemic stroke. The relationship of low mtDNA content and ischemic stroke was particularly notable in individuals who had low mtDNA content combined with diabetes mellitus, metabolic syndrome, or cigarette smoking. Oxidative stress may be one of the contributory factors to decreased mtDNA content in patients with ischemic stroke.
C1 [Lien, Li-Ming; Yeh, Hsu-Ling] Shin Kong WHS Mem Hosp, Dept Neurol, Taipei, Taiwan.
   [Lien, Li-Ming; Yeh, Hsu-Ling; Hu, Chaur-Jong] Taipei Med Univ, Sch Med, Coll Med, Taipei, Taiwan.
   [Chiou, Hung-Yi; Chiu, Shang-Yen; Hsieh, Fang-I] Taipei Med Univ, Coll Publ Hlth, Sch Publ Hlth, Taipei, Taiwan.
   [Jeng, Jiann-Shing] Natl Taiwan Univ Hosp, Stroke Ctr, Taipei, Taiwan.
   [Jeng, Jiann-Shing] Natl Taiwan Univ Hosp, Dept Neurol, Taipei, Taiwan.
   [Lin, Huey-Juan] Chi Mel Med Ctr, Dept Neurol, Tainan, Taiwan.
   [Hu, Chaur-Jong] Taipei Med Univ, Shuang Ho Hosp, Dept Neurol, New Taipei, Taiwan.
   [Wei, Yau-Huei] Mackay Med Coll, Dept Med, New Taipei, Taiwan.
   [Wei, Yau-Huei] Changhua Christian Hosp, Ctr Mitochondrial Med & Free Radical Res, Changhua, Taiwan.
C3 Shin Kong Wu Ho Su Memorial Hospital; Taipei Medical University; Taipei
   Medical University; National Taiwan University; National Taiwan
   University Hospital; National Taiwan University; National Taiwan
   University Hospital; Taipei Medical University; Shuang Ho Hospital;
   Mackay Medical College; Changhua Christian Hospital
RP Hsieh, FI (corresponding author), Taipei Med Univ, Coll Publ Hlth, Sch Publ Hlth, Taipei, Taiwan.
EM hsiehfangi@tmu.edu.tw
RI Chuang, Hung-Yi/C-9143-2009; Wei, Yau-Huei/ABA-6841-2021
OI Hsieh, Fang-I/0000-0001-8805-9020; JENG,
   JIANN-SHING/0000-0002-1456-3686; Wei, Yau-Huei/0000-0002-6429-2546;
   Chiou, Hung Yi/0000-0002-4545-9697
FU Ministry of Science and Technology of Taiwan Government
   [MOST104-2627-M-715-002, MOST103-2314-B-038-020,
   NSC100-2314-B-038-030-MY3]; Ministry of Health and Welfare
   [MOHW105-TDU-B-212-133018]; Taipei Medical University [SKH-TMU-102-01];
   Dr. Chi-Chin Huang Stroke Research Center
FX This work was supported in part by grants (MOST104-2627-M-715-002,
   MOST103-2314-B-038-020, and NSC100-2314-B-038-030-MY3) from the Ministry
   of Science and Technology of Taiwan Government, the Ministry of Health
   and Welfare (MOHW105-TDU-B-212-133018), Taipei Medical University
   (SKH-TMU-102-01), and the Dr. Chi-Chin Huang Stroke Research Center.
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NR 51
TC 26
Z9 27
U1 2
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2047-9980
J9 J AM HEART ASSOC
JI J. Am. Heart Assoc.
PD NOV
PY 2017
VL 6
IS 11
AR e006157
DI 10.1161/JAHA.117.006157
PG 14
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA FR3CO
UT WOS:000418943800009
PM 29151031
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Ardakanian, A
   Rahbardar, MG
   Omidkhoda, F
   Razavi, BM
   Hosseinzadeh, H
AF Ardakanian, Alireza
   Rahbardar, Mahboobeh Ghasemzadeh
   Omidkhoda, Farzaneh
   Razavi, Bibi Marjan
   Hosseinzadeh, Hossein
TI Effect of alpha-mangostin on olanzapine-induced metabolic disorders in
   rats
SO IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
LA English
DT Article
DE Anti-oxidants; Leptin; Liver; Mangostin; Metabolic syndrome; Obesity;
   Olanzapine; Weight gain
ID WEIGHT-GAIN; ANTIPSYCHOTIC-DRUGS; GARCINIA-MANGOSTANA; OXIDATIVE STRESS;
   OBESITY; LEPTIN; HYPERPHAGIA; INVOLVEMENT; RESISTANCE; PATHWAYS
AB Objective(s): As olanzapine has side effects such as weight gain and metabolic disorders, and alpha-mangostin has been shown to control metabolic disorders, the effects of alpha-mangostin on metabolic disorders induced by olanzapine were investigated in this study. Materials and Methods: Obesity was induced in female Wistar rats by daily administration of olanzapine (5 mg/kg/day, IP, 14 days). Rats were divided into 6 groups:1) vehicle (control); 2) olanzapine (5 mg/kg/day); 3,4,5) olanzapine+ alpha-mangostin (10, 20, 40 mg/kg/day, IP); 6) alphamangostin (40 mg/kg/day). Weight changes were measured every 3 days and food intake was assessed every day. Systolic blood pressure, plasma levels of blood sugar, triglycerides, total cholesterol, HDL, LDL, leptin, oxidative stress markers (MDA, GSH), AMPK, and P-AMPK protein levels in liver tissue were assessed on the last day of the study. Results: Administration of olanzapine significantly increased weight gain, food intake, blood pressure, triglycerides, LDL, blood sugar, leptin, and MDA in rat liver tissue and also decreased GSH, AMPK, and P-AMPK in liver tissue compared with the control group. Different doses of alpha-mangostin significantly reduced weight gain, food intake, systolic blood pressure, triglycerides, LDL, blood sugar, leptin, and MDA. Also, they significantly increased GSH, AMPK, and P-AMPK in liver tissue compared with the olanzapine group. Conclusion: Olanzapine increases leptin levels, food intake, and weight, induces oxidative stress, decreases the levels of AMPK and P-AMPK proteins in liver tissue, and causes metabolic disorders. But, alpha-mangostin reduces the negative effects of olanzapine by activation of AMPK.
C1 [Ardakanian, Alireza; Rahbardar, Mahboobeh Ghasemzadeh; Omidkhoda, Farzaneh; Razavi, Bibi Marjan; Hosseinzadeh, Hossein] Mashhad Univ Med Sci, Sch Pharm, Dept Pharmacodynam & Toxicol, Mashhad, Razavi Khorasan, Iran.
   [Razavi, Bibi Marjan] Mashhad Univ Med Sci, Targeted Drug Delivery Res Ctr, Pharmaceut Technol Inst, Mashhad, Razavi Khorasan, Iran.
   [Hosseinzadeh, Hossein] Mashhad Univ Med Sci, Pharmaceut Res Ctr, Pharmaceut Technol Inst, Mashhad, Razavi Khorasan, Iran.
C3 Mashhad University of Medical Sciences; Mashhad University of Medical
   Sciences; Mashhad University of Medical Sciences
RP Razavi, BM (corresponding author), Mashhad Univ Med Sci, Targeted Drug Delivery Res Ctr, Pharmaceut Technol Inst, Mashhad, Razavi Khorasan, Iran.; Hosseinzadeh, H (corresponding author), Mashhad Univ Med Sci, Pharmaceut Res Ctr, Pharmaceut Technol Inst, Mashhad, Razavi Khorasan, Iran.
EM razavimr@mums.ac.ir; hosseinzadehh@mums.ac.ir
RI Ghasemzadeh Rahbardar, Mahboobeh/V-4452-2019; Razavi,
   Bibi/AAY-5636-2020; Hosseinzadeh, Hossein/F-3013-2010
OI Ghasemzadeh Rahbardar, Mahboobeh/0000-0002-5491-572X
FU Mashhad University of Medical Sciences
FX The results presented in this paper were part of a student thesis. The
   authors are thankful to Mashhad University of Medical Sciences for
   financial supports.
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NR 69
TC 26
Z9 26
U1 0
U2 6
PU MASHHAD UNIV MED SCIENCES
PI MASHHAD
PA VICE-CHANCELLOR FOR RES CTR OFF IJBMS, DANESHGAH ST, PO BOX 9138813944 -
   445, MASHHAD, 00000, IRAN
SN 2008-3866
EI 2008-3874
J9 IRAN J BASIC MED SCI
JI Iran. J. Basic Med. Sci.
PD FEB
PY 2022
VL 25
IS 2
BP 198
EP 207
DI 10.22038/IJBMS.2022.58734.13047
PG 10
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA ZC4RX
UT WOS:000757510500003
PM 35655598
DA 2025-06-11
ER

PT J
AU Siervo, M
   Shannon, OM
   Llewellyn, DJ
   Stephan, BCM
   Fontana, L
AF Siervo, Mario
   Shannon, Oliver M.
   Llewellyn, David J.
   Stephan, Blossom C. M.
   Fontana, Luigi
TI Mediterranean diet and cognitive function: From methodology to
   mechanisms of action
SO FREE RADICAL BIOLOGY AND MEDICINE
LA English
DT Article
DE Mediterranean diet; Dementia; Cognitive function; Nutrition; Prevention
ID CORONARY-ARTERY-DISEASE; VIRGIN OLIVE OIL; BLOOD-PRESSURE; INORGANIC
   NITRATE; OXIDATIVE STRESS; NITRIC-OXIDE; METABOLIC SYNDROME; DEMENTIA
   RISK; LIFE-STYLE; ALZHEIMERS-DISEASE
AB The traditional Mediterranean diet (MedDiet), rich in minimally processed plant foods and fish, has been widely recognized to be one of the healthiest diets. Data from multiple randomized clinical trials have demonstrated its powerful effect against oxidative stress, inflammation and the development and progression of cardiovascular disease, type 2 diabetes, and other metabolic conditions that play a crucial role in the pathogenesis of neurodegenerative diseases. The protecting effects of the MedDiet against cognitive decline have been investigated in several observational and experimental studies. Data from observational studies suggest that the MedDiet may represent an effective dietary strategy for the early prevention of dementia, although these findings require further substantiation in clinical trials which have so far produced inconclusive results. Moreover, as we discuss in this review, accumulating data emphasizes the importance of: 1) maintaining an optimal nutritional and metabolic status for the promotion of healthy cognitive aging, and 2) implementing cognition-sparing dietary and lifestyle interventions during early time-sensitive windows before the pathological cascades turn into an irreversible state. In summary, components of the MedDiet pattern, such as essential fatty acids, polyphenols and vitamins, have been associated with reduced oxidative stress and the current evidence from observational studies seems to assign to the MedDiet a beneficial role in promoting brain health; however, results from clinical trials have been inconsistent. While we advocate for longitudinal analyses and for larger and longer clinical trials to be conducted, we assert our interim support to the use of the MedDiet as a protective dietary intervention for cognitive function based on its proven cardiovascular and metabolic benefits.
C1 [Siervo, Mario] Univ Nottingham, Queens Med Ctr, Sch Life Sci, Med Sch, Nottingham, England.
   [Shannon, Oliver M.] Newcastle Univ, Human Nutr Res Ctr, Populat Hlth Sci Inst, Newcastle Upon Tyne, Tyne & Wear, England.
   [Llewellyn, David J.] Univ Exeter, Med Sch, Exeter, Devon, England.
   [Llewellyn, David J.] Alan Turing Inst, London, England.
   [Stephan, Blossom C. M.] Univ Nottingham, Inst Mental Hlth, Med Sch, Nottingham, England.
   [Fontana, Luigi] Univ Sydney, Fac Med & Hlth, Charles Perkins Ctr, Sydney, NSW, Australia.
   [Fontana, Luigi] Royal Prince Alfred Hosp, Dept Endocrinol, Sydney, NSW, Australia.
   [Fontana, Luigi] Brescia Univ, Dept Clin & Expt Sci, Sch Med, Brescia, Italy.
C3 University of Nottingham; Newcastle University - UK; University of
   Exeter; Alan Turing Institute; University of Nottingham; University of
   Sydney; University of Sydney; NSW Health; Royal Prince Alfred Hospital;
   University of Brescia
RP Siervo, M (corresponding author), Univ Nottingham, Queens Med Ctr, Sch Life Sci, Med Sch, Nottingham, England.
EM Mario.Siervo@nottingham.ac.uk
RI Llewellyn, David/AAZ-2859-2021; Fontana, Luigi/K-4773-2013; Stephan,
   Blossom/A-1560-2009; Siervo, Mario/LIG-2137-2024
OI Llewellyn, David/0000-0002-2441-4246; Shannon,
   Oliver/0000-0001-8208-6837; Siervo, Mario/0000-0001-5515-0944; Fontana,
   Luigi/0000-0001-8500-5537
FU Alzheimer's Research UK Prevention and Risk Reduction Fund
   [ARUK-PRRF2017-006]; UK Nutrition Research Partnership (UK NRP); Medical
   Research Council (MRC); Biotechnology and Biological Sciences Research
   Council (BBSRC); National Institute for Health Research (NIHR)
   [MR/T001852/1]; Australian NHMRC Investigator Grant [APP1177797];
   Australian Youth and Health Foundation; Bakewell Foundation; National
   Institute for Health Research (NIHR) Applied Research Collaboration
   (ARC) South West Peninsula; Alzheimer's Research UK; National Health and
   Medical Research Council (NHMRC); JP Moulton Foundation; National
   Institute on Aging/National Institutes of Health [RF1AG055654]; Alan
   Turing Institute/Engineering and Physical Sciences Research Council
   [EP/N510129/1]; MRC [MR/T001852/1] Funding Source: UKRI
FX This research was supported by the Alzheimer's Research UK Prevention
   and Risk Reduction Fund (ARUK-PRRF2017-006) and the UK Nutrition
   Research Partnership (UK NRP), an initiative supported by the Medical
   Research Council (MRC), Biotechnology and Biological Sciences Research
   Council (BBSRC) and the National Institute for Health Research (NIHR)
   (MR/T001852/1). LF is supported by grants from the Australian NHMRC
   Investigator Grant (APP1177797), Australian Youth and Health Foundation,
   and Bakewell Foundation. DJL is supported by the National Institute for
   Health Research (NIHR) Applied Research Collaboration (ARC) South West
   Peninsula, Alzheimer's Research UK, National Health and Medical Research
   Council (NHMRC), JP Moulton Foundation, National Institute on
   Aging/National Institutes of Health (RF1AG055654), and the Alan Turing
   Institute/Engineering and Physical Sciences Research Council
   (EP/N510129/1).
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NR 225
TC 51
Z9 51
U1 3
U2 35
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0891-5849
EI 1873-4596
J9 FREE RADICAL BIO MED
JI Free Radic. Biol. Med.
PD NOV 20
PY 2021
VL 176
BP 105
EP 117
DI 10.1016/j.freeradbiomed.2021.09.018
EA SEP 2021
PG 13
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA WG1XB
UT WOS:000706790100001
PM 34562607
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Raff, H
   Hoeynck, B
   Jablonski, M
   Leonovicz, C
   Phillips, JM
   Gehrand, AL
AF Raff, Hershel
   Hoeynck, Brian
   Jablonski, Mack
   Leonovicz, Cole
   Phillips, Jonathan M.
   Gehrand, Ashley L.
TI Insulin sensitivity, leptin, adiponectin, resistin, and testosterone in
   adult male and female rats after maternal-neonatal separation and
   environmental stress
SO AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE
   PHYSIOLOGY
LA English
DT Article
DE HOMA-IR; adipokines; leptin; androgens; neonatal stress; sex difference
ID HYPOXIC-ISCHEMIC ENCEPHALOPATHY; BODY-TEMPERATURE MAINTENANCE;
   STIMULATION MTS INTERVENTION; BIRTH-WEIGHT INFANTS; SKIN KANGAROO CARE;
   EARLY-LIFE STRESS; CORTICOSTERONE RESPONSES; PREMATURE-INFANTS;
   METABOLIC SYNDROME; PANCREATIC-ISLETS
AB Care of premature infants often requires parental and caregiver separation, particularly during hypoxic and hypothermic episodes. We have established a neonatal rat model of human prematurity involving maternal-neonatal separation and hypoxia with spontaneous hypothermia prevented by external heat. Adults previously exposed to these neonatal stressors show a sex difference in the insulin and glucose response to arginine stimulation suggesting a state of insulin resistance. The current study used this cohort of adult rats to evaluate insulin resistance [homeostatic model assessment of insulin resistance (HOMA-IR)], plasma adipokines (reflecting insulin resistance states), and testosterone. The major findings were that daily maternal-neonatal separation led to an increase in body weight and HOMA-IR in adult male and female rats and increased plasma leptin in adult male rats only; neither prior neonatal hypoxia (without or with body temperature control) nor neonatal hypothermia altered subsequent adult HOMA-IR or plasma adiponectin. Adult male-female differences in plasma leptin were lost with prior exposure to neonatal hypoxia or hypothermia; male-female differences in resistin were lost in the adults that were exposed to hypoxia and spontaneous hypothermia as neonates. Exposure of neonates to daily hypoxia without spontaneous hypothermia led to a decrease in plasma testosterone in adult male rats. We conclude that neonatal stressors result in subsequent adult sex-dependent increases in insulin resistance and adipokines and that our rat model of prematurity with hypoxia without hypothermia alters adult testosterone dynamics.
C1 [Raff, Hershel; Hoeynck, Brian; Jablonski, Mack; Leonovicz, Cole; Phillips, Jonathan M.; Gehrand, Ashley L.] Aurora St Lukes Med Ctr, Aurora Res Inst, Endocrine Res Lab, Milwaukee, WI 53215 USA.
   [Raff, Hershel] Med Coll Wisconsin, Dept Med, Milwaukee, WI 53226 USA.
   [Raff, Hershel] Med Coll Wisconsin, Dept Surg, 8700 W Wisconsin Ave, Milwaukee, WI 53226 USA.
   [Raff, Hershel] Med Coll Wisconsin, Dept Physiol, 8701 Watertown Plank Rd, Milwaukee, WI 53226 USA.
C3 Medical College of Wisconsin; Medical College of Wisconsin; Medical
   College of Wisconsin
RP Raff, H (corresponding author), Aurora St Lukes Med Ctr, Endocrinol, 2801 W KK River Pkwy,Suite 245, Milwaukee, WI 53215 USA.
EM hraff@mcw.edu
FU Aurora Research Institute
FX This study was funded by the Aurora Research Institute.
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NR 90
TC 23
Z9 25
U1 0
U2 9
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0363-6119
EI 1522-1490
J9 AM J PHYSIOL-REG I
JI Am. J. Physiol.-Regul. Integr. Comp. Physiol.
PD JAN
PY 2018
VL 314
IS 1
BP R12
EP R21
DI 10.1152/ajpregu.00271.2017
PG 10
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA FR2YQ
UT WOS:000418933500002
PM 28877872
DA 2025-06-11
ER

PT J
AU Maheshwari, RA
   Parmar, GR
   Hinsu, D
   Seth, AK
   Balaraman, R
AF Maheshwari, Rajesh A.
   Parmar, Ghanshyam R.
   Hinsu, Denish
   Seth, Avinash K.
   Balaraman, Ramachandran
TI Novel therapeutic intervention of coenzyme Q10 and its combination with
   pioglitazone on the mRNA expression level of adipocytokines in diabetic
   rats
SO LIFE SCIENCES
LA English
DT Article
DE Adipocytokines; Antioxidant enzymes; Coenzyme Q10; Pioglitazone and mRNA
   expression; White adipose tissue
ID OXIDATIVE STRESS; INSULIN-RESISTANCE; DIFFERENTIAL REGULATION; METABOLIC
   SYNDROME; INFLAMMATION; PROTEIN; NEPHROPATHY; ADIPONECTIN; DYSFUNCTION;
   OBESITY
AB Aims: Aim of the present study was to investigate the effect of co-administration coenzyme Q10 and pioglitazone on the mRNA expression of adipocytokines in white adipose tissues of chemically induced type 2 diabetes mellitus in rats.
   Main methods: Diabetes was induced by administration of streptozotocin (65 mg/kg, i.p.), followed by nicotinamide (110 mg/kg, i.p.) 15 min later. The diabetic rats were treated coenzyme Q10 (Q10, 10 mg/kg, p.o.) or pioglitazone (PIO, 20 mg/kg, p.o.) alone and their combination for four weeks. Biochemical parameters like FBS level, insulin and HbAlc along with tissue levels of MDA, SOD, CAT and GSH were estimated. The mRNA levels of ADIPOQ, RBP4, RETN, IL-6 and TNF-alpha in White Adipose Tissue (WAT) were measured.
   Key findings: Treatment with Q10 + PIO showed a significant reduction in the levels of FBS, HbAlc and a significant increase in insulin levels as compared to normal control group. Additionally, there was a significant change in the levels of biomarkers of oxidative stress after treatment with Q10 + PIO as compared to streptozotocin-nicotinamide group. Treatment with Q10 + PIO also significantly altered the mRNA expression of ADIPOQ, RETN, IL-6 and TNF-alpha when compared to monotherapy. However, mRNA expression of RBP4 did not alter in Q10 + PIO treated animal as compared to Q10 or PIO alone.
   Significance: It is concluded that co-administration of Q10 and PIO has been shown the better therapeutic effect on the mRNA expression of adipocytokines and oxidative stress parameters as compared to either Q10 or PIO.
C1 [Maheshwari, Rajesh A.; Parmar, Ghanshyam R.; Hinsu, Denish; Seth, Avinash K.; Balaraman, Ramachandran] Sumandeep Vidyapeeth Deemed Be Univ, Dept Pharm, Post Piparia, Vadodara 391760, Gujarat, India.
C3 Sumandeep Vidyapeeth
RP Parmar, GR (corresponding author), Sumandeep Vidyapeeth Deemed Be Univ, Dept Pharm, Post Piparia, Vadodara 391760, Gujarat, India.
EM ghanstaurus22@gmail.com
RI Parmar, Ghanshyam/F-6611-2013; Seth, Avinash/KWU-2615-2024; Maheshwari,
   Rajesh/AAV-5600-2020
OI SETH, Dr. A. K./0000-0003-4970-727X
FU Sumandeep Vidyapeeth Deemed to be University, Piparia, Waghodia,
   Vadodara, Gujarat, India from Research cell [SVRC/ON/2015/15264]
FX This work was supported by the Sumandeep Vidyapeeth Deemed to be
   University, Piparia, Waghodia, Vadodara-391760, Gujarat, India (Ref. no.
   SVRC/ON/2015/15264) from Research cell, to Dr. Ramachandran Balaraman
   (PhD, FAMS) Principle Investigator.
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NR 60
TC 8
Z9 9
U1 0
U2 2
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0024-3205
EI 1879-0631
J9 LIFE SCI
JI Life Sci.
PD OCT 1
PY 2020
VL 258
AR 118155
DI 10.1016/j.lfs.2020.118155
PG 8
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA NW7BJ
UT WOS:000575171600004
PM 32735887
DA 2025-06-11
ER

PT J
AU Torkanlou, K
   Bibak, B
   Abbaspour, A
   Abdi, H
   Moghaddam, MS
   Tayefi, M
   Mohammadzadeh, E
   Bana, HS
   Aghasizade, M
   Ferns, GA
   Avan, A
   Mobarhan, MG
AF Torkanlou, Khadijeh
   Bibak, Bahram
   Abbaspour, Alireza
   Abdi, Hamid
   Moghaddam, Masoud Saleh
   Tayefi, Maryam
   Mohammadzadeh, Elham
   Bana, Hamideh Safarian
   Aghasizade, Maliheh
   Ferns, Gordon A.
   Avan, Amir
   Mobarhan, Majid Ghayour
TI Reduced Serum Levels of Zinc and Superoxide Dismutase in Obese
   Individuals
SO ANNALS OF NUTRITION AND METABOLISM
LA English
DT Article
DE Oxidant stress; Obesity; Superoxide dismutase; Zinc; Copper
ID CORONARY-ARTERY-DISEASE; METABOLIC SYNDROME; CONTROLLED-TRIAL;
   HEART-DISEASE; DIETARY ZINC; COPPER; ASSOCIATION; MAGNESIUM;
   POLYMORPHISM; POPULATIONS
AB The oxidant-stress (OS) has an essential role to play in the pathogenesis and progression of many diseases. OS is the outcome when the level of free-radical-formation is increased or protective-antioxidant-mechanisms are compromised. Its value is expected to increase, although its emerging roles have not been conclusive in different studies. The objective of this study was to explore the level of zinc, copper, and antioxidant in response to obesity-related-stress by measuring superoxide-dismutase (SOD) levels as a key antioxidant-enzyme in 706 individuals with/without obesity. Anthropomet-ric/biochemical parameters including total-cholesterol (TC), fasting-blood-glucose, high-density-lipoprotein (HDL), low-density-lipoprotein, and triglycerides were determined. The activity of SOD was measured followed by the measurement of Cu and Zn levels. Obese subjects had a significantly higher level of body mass index (BMI) and TC, while the level of HDL was lower in the obese group, as compared to the related values in control subjects. The level of Zn was significantly decreased in the obese group, while the level of Cu and Cu/Zn ratio increased. Additionally, we observed that the SOD level was less in obese subjects when compared to that in the non-obese subjects. In addition to the complications of high BMI, low level of Zn and SOD in obesity can be considered a risk factor, resulting in a reduced antioxidant response, supporting the need for identifying a suitable treatment option for this group. (C) 2016 S. Karger AG, Basel
C1 [Torkanlou, Khadijeh; Tayefi, Maryam; Mohammadzadeh, Elham; Bana, Hamideh Safarian; Aghasizade, Maliheh; Avan, Amir; Mobarhan, Majid Ghayour] Mashhad Univ Med Sci, Metab Syndrome Res Ctr, Sch Med, Mashhad 9919991766, Iran.
   [Torkanlou, Khadijeh; Moghaddam, Masoud Saleh] Payame Noor Univ, Fac Sci, Dept Biochem, Mashhad, Iran.
   [Bibak, Bahram; Abbaspour, Alireza] North Khorasan Univ Med Sci, Sch Med, Dept Physiol & Pharmacol, Bojnurd, Iran.
   [Abdi, Hamid] Mashhad Univ Med Sci, Fac Tradit Med, Mashhad, Iran.
   [Ferns, Gordon A.] Brighton & Sussex Med Sch, Div Med Educ, Brighton, E Sussex, England.
C3 Mashhad University of Medical Sciences; Payame Noor University; North
   Khorasan University of Medical Sciences; Mashhad University of Medical
   Sciences; University of Sussex; University of Brighton
RP Avan, A (corresponding author), Mashhad Univ Med Sci, Metab Syndrome Res Ctr, Sch Med, Mashhad 9919991766, Iran.; Mobarhan, MG (corresponding author), Mashhad Univ Med Sci, Metab Syndrome Res Ctr, Fac Med, Mashhad 9919991766, Iran.
EM avana@mums.ac.ir; ghayourm@mums.ac.ir
RI Ghayour-Mobarhan, Majid/AAY-5963-2020; shahidsales,
   soudabe/AAY-2920-2020; abbaspour, alireza/ABC-7804-2020
OI Aghasizadeh, Malihe/0000-0001-8562-360X; naseri,
   shahrokh/0000-0001-8974-2120; tayefi, maryam/0000-0003-4637-7754
FU Mashhad University of Medical Sciences
FX This study was supported by a grant from the Mashhad University of
   Medical Sciences.
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NR 30
TC 31
Z9 33
U1 1
U2 4
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0250-6807
EI 1421-9697
J9 ANN NUTR METAB
JI Ann. Nutr. Metab.
PY 2016
VL 69
IS 3-4
BP 232
EP 236
DI 10.1159/000454894
PG 5
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA EI9JI
UT WOS:000392823700009
PM 28002829
DA 2025-06-11
ER

PT J
AU Zhang, JX
   Zhang, YJ
   Liu, HW
   Bai, H
   Wang, Y
   Jiang, CA
   Fan, P
AF Zhang, Jinxia
   Zhang, Yujin
   Liu, Hongwei
   Bai, Huai
   Wang, Ying
   Jiang, Changan
   Fan, Ping
TI Antioxidant properties of high-density lipoproteins are impaired in
   women with polycystic ovary syndrome
SO FERTILITY AND STERILITY
LA English
DT Article
DE Polycystic ovary syndrome; dysfunctional high-density lipoprotein;
   oxidative stress; inflammation; dyslipidemia
ID HORMONE-REPLACEMENT THERAPY; WEST CHINESE WOMEN; POSTMENOPAUSAL WOMEN;
   OXIDATIVE STRESS; METABOLIC SYNDROME; OXIDIZED PHOSPHOLIPIDS;
   SIMVASTATIN TREATMENT; DIAGNOSTIC-CRITERIA; A-I; HDL
AB Objective: To determine the relationships among the inflammatory index, intrinsic oxidation levels, lipid and apolipoprotein (apo) A-I concentrations of high-density lipoprotein (HDL), and polycystic ovary syndrome (PCOS).
   Design: Cross-sectional study.
   Setting: University hospital.
   Patient(s): A total of 425 patients with PCOS and 441 control women were included.
   Intervention(s): None.
   MainOutcomeMeasure(s): The HDL inflammatory index(HII) was determined using a cell-free fluorometric assay. Intrinsic HDL oxidation levels, HDL-free cholesterol, HDL-cholesterol ester, HDL-triglyceride, serum apoA-I, and malondialdehyde levels were also measured.
   Result(s): The mean HII value and the frequency of HII >= 1 were significantly higher in the PCOS group (0.77 +/- 0.54, 27.1%) than in the control group (0.53 +/- 0.37, 8.4%). These values were also higher in each of the 4 PCOS phenotypes based on the Rotterdam criteria than in the controls, and higher in patients with hyperandrogenism (HA) + oligo-and/or anovulation (OA) phenotype than in those with OA + polycystic ovary (PCO) phenotype. Furthermore, patients with PCOS with OA + PCO had lower malondialdehyde and intrinsic HDL oxidation levels compared with those with HA. Multivariate regression analysis demonstrated that PCOS, HDL-cholesterol ester, and E-2 levels were the main predictors of HII value.
   Conclusion(s): The impairment of HDL antioxidant/anti-inflammatory function in PCOS is related to HA status, increased oxidative stress, and abnormalities in HDL components and thus may contribute to PCOS pathogenesis and increase the risks of future cardiovascular diseases.(C) 2015 by American Society for Reproductive Medicine.
C1 [Zhang, Jinxia; Bai, Huai; Jiang, Changan; Fan, Ping] Sichuan Univ, West China Hosp 2, Key Lab Birth Defects & Related Dis Women & Child, Lab Genet Dis & Perinatal Med,Minist Educ, Chengdu 610041, Sichuan, Peoples R China.
   [Zhang, Yujin; Liu, Hongwei; Wang, Ying] Sichuan Univ, West China Hosp 2, Dept Obstet & Gynecol, Chengdu 610041, Sichuan, Peoples R China.
C3 Sichuan University; Ministry of Education - China; Sichuan University
RP Fan, P (corresponding author), Sichuan Univ, West China Hosp 2, Lab Genet Dis & Perinatal Med, Chengdu 610041, Sichuan, Peoples R China.
EM fanping15@scu.edu.cn
FU Chinese National Natural Science Foundation [81070463, 81370681];
   Program for Changjiang Scholars and Innovative Research Team in
   University, Ministry of Education [IRT0935]
FX Financial support was received from the Chinese National Natural Science
   Foundation (grants 81070463 and 81370681) and the Program for Changjiang
   Scholars and Innovative Research Team in University, Ministry of
   Education (grant IRT0935).
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NR 52
TC 33
Z9 34
U1 0
U2 10
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0015-0282
EI 1556-5653
J9 FERTIL STERIL
JI Fertil. Steril.
PD MAY
PY 2015
VL 103
IS 5
BP 1346
EP 1354
DI 10.1016/j.fertnstert.2015.02.024
PG 9
WC Obstetrics & Gynecology; Reproductive Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology; Reproductive Biology
GA CH2GM
UT WOS:000353843700041
PM 25813288
OA Bronze
DA 2025-06-11
ER

PT J
AU Silva, TO
   Jung, IEC
   Moresco, RN
   Barbisan, F
   Ribeiro, EE
   Ribeiro, EAM
   Motta, K
   Britto, E
   Tasch, E
   Bochi, G
   Duarte, MMF
   Oliveira, AR
   Marcon, M
   Belló, C
   Montagner, GFD
   da Cruz, IBM
AF Silva, T. O.
   Jung, I. E. C.
   Moresco, R. N.
   Barbisan, F.
   Ribeiro, E. E.
   Ribeiro, E. A. M.
   Motta, K.
   Britto, E.
   Tasch, E.
   Bochi, G.
   Duarte, M. M. F.
   Oliveira, A. R.
   Marcon, M.
   Bello, C.
   Montagner, G. F. dos Santos
   da Cruz, I. B. M.
TI Association between advanced oxidation protein products and 5-year
   mortality risk among amazon riparian elderly population
SO FREE RADICAL RESEARCH
LA English
DT Article
DE advanced oxidation protein products; aging; epidemiology
ID METABOLIC SYNDROME; MODIFIED FORMS; STRESS; ALBUMIN; MARKERS; COMMUNITY
AB Proteins are important targets of several modifications caused by oxidative stress, leading to structural changes and consequently partial or total loss of their functions. The oxidized proteins include advanced oxidation protein products (AOPP) derived from oxidation-modified albumin, as well as fibrinogen and lipoproteins. An increase in AOPP levels indicates an oxidative stress state and the presence of coexisting inflammation. Several investigations have also suggested an association between high AOPP levels and aging-related diseases. However, the link between elevated AOPP levels and elderly mortality risk has not yet been investigated. Here, we report on a 5-year longitudinal study that investigated the potential association between AOPP levels and mortality using a population-based representative sample of riparian elders living in Brazilian Amazon region (Maues-AM). Age, sex, socioeconomic and cultural conditions, chronic morbidities, polypharmacy, and previous morbidities were also tested as potential confounders. The AOPP levels were measured in 540 (84.78%) individuals, all of whom were followed over a 5-year period in order to establish the mortality rate. Within this study period, 74 (13.7%) elders died and 466 (86.3%) survived. The AOPP levels were higher among the elders who died within the 5-year period (46.27 +/- 40.6 mmol/L) compared with those who survived (36.79 +/- 20.84 mmol/L) (p = 0.002). The analysis confirmed the link between high AOPP levels and mortality risk, independent of other intervenient factors. These results suggest that elevated AOPP levels could be used to predict mortality risk in elderly patients.
C1 [Silva, T. O.; da Cruz, I. B. M.] Univ Fed Santa Maria, Programa Posgrad Bioquim Toxicol, Santa Maria, RS, Brazil.
   [Jung, I. E. C.; Barbisan, F.; da Cruz, I. B. M.] Univ Fed Santa Maria, Programa Posgrad Farmacol, Santa Maria, RS, Brazil.
   [Duarte, M. M. F.; Oliveira, A. R.; Marcon, M.; Bello, C.; Montagner, G. F. dos Santos; da Cruz, I. B. M.] Univ Fed Santa Maria, Lab Biogen, Santa Maria, RS, Brazil.
   [Ribeiro, E. E.; Ribeiro, E. A. M.; Motta, K.; Britto, E.] Univ Estado Amazonas, Univ Aberta Terceira Idade, Manaus, Amazonas, Brazil.
   [Moresco, R. N.; Tasch, E.; Bochi, G.] Univ Fed Santa Maria, Programa Posgrad Ciencias Farmaceut, Santa Maria, RS, Brazil.
C3 Universidade Federal de Santa Maria (UFSM); Universidade Federal de
   Santa Maria (UFSM); Universidade Federal de Santa Maria (UFSM);
   Universidade do Estado do Amazonas; Universidade Federal de Santa Maria
   (UFSM)
RP da Cruz, IBM (corresponding author), Av Roraima 1000,Predio 19, BR-97105900 Santa Maria, RS, Brazil.
EM ibmcruz@hotmail.com
RI Barbisan, Fernanda/AAS-5551-2020; Silva, Talis/AAL-6102-2021; da Cruz;
   Manica da Cruz, Ivana/G-4329-2012; Moresco, Rafael/K-6118-2017
OI Barbisan, Fernanda/0000-0002-2960-7047; da Cruz; Manica da Cruz,
   Ivana/0000-0003-3008-6899; Moresco, Rafael/0000-0003-3072-5080; Bochi,
   Guilherme/0000-0003-1871-1356
FU Fundacao de Amparo a Pesquisa do Amazonas (FAPEAM); Conselho Nacional de
   Pesquisa e Desenvolvimento (CNPq); Coordenacao de Pessoal de Ensino
   Superior (CAPES); Fundacao de Amparo a Pesquisa do Rio Grande do Sul
   (FAPERGS)
FX We are grateful to the Maues governmental team, as well as the
   professionals of UnATI/UEA, for assisting us in the data collection. We
   are also grateful to Prefeitura Municipal de Maues and Amazonas ESF-SUS.
   This study was supported by grants and fellowships from Fundacao de
   Amparo a Pesquisa do Amazonas (FAPEAM), Conselho Nacional de Pesquisa e
   Desenvolvimento (CNPq), Coordenacao de Pessoal de Ensino Superior
   (CAPES), and Fundacao de Amparo a Pesquisa do Rio Grande do Sul
   (FAPERGS).
CR [Anonymous], 2013, ALB AN MON ASS CLIN
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NR 28
TC 5
Z9 5
U1 0
U2 3
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1071-5762
EI 1029-2470
J9 FREE RADICAL RES
JI Free Radic. Res.
PD FEB
PY 2015
VL 49
IS 2
BP 204
EP 209
DI 10.3109/10715762.2014.992895
PG 6
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA CB4SH
UT WOS:000349617800010
PM 25496432
DA 2025-06-11
ER

PT J
AU Kelley, EE
   Baust, J
   Bonacci, G
   Golin-Bisello, F
   Devlin, JE
   St Croix, CM
   Watkins, SC
   Gor, S
   Cantu-Medellin, N
   Weidert, ER
   Frisbee, JC
   Gladwin, MT
   Champion, HC
   Freeman, BA
   Khoo, NKH
AF Kelley, Eric E.
   Baust, Jeff
   Bonacci, Gustavo
   Golin-Bisello, Franca
   Devlin, Jason E.
   St Croix, Claudette M.
   Watkins, Simon C.
   Gor, Sonia
   Cantu-Medellin, Nadiezhda
   Weidert, Eric R.
   Frisbee, Jefferson C.
   Gladwin, Mark T.
   Champion, Hunter C.
   Freeman, Bruce A.
   Khoo, Nicholas K. H.
TI Fatty acid nitroalkenes ameliorate glucose intolerance and pulmonary
   hypertension in high-fat diet-induced obesity
SO CARDIOVASCULAR RESEARCH
LA English
DT Article
DE Obesity; Pulmonary hypertension; Nitro-fatty acid signalling;
   Inflammation; Xanthine Oxidase
ID ARTERIAL-HYPERTENSION; XANTHINE-OXIDASE; NITRIC-OXIDE; OXIDATIVE STRESS;
   METABOLIC SYNDROME; DISEASE; INFLAMMATION; INHIBITION; GENERATION;
   HYPOXIA
AB Aims Obesity is a risk factor for diabetes and cardiovascular diseases, with the incidence of these disorders becoming epidemic. Pathogenic responses to obesity have been ascribed to adipose tissue (AT) dysfunction that promotes bioactive mediator secretion from visceral AT and the initiation of pro-inflammatory events that induce oxidative stress and tissue dysfunction. Current understanding supports that suppressing pro-inflammatory and oxidative events promotes improved metabolic and cardiovascular function. In this regard, electrophilic nitro-fatty acids display pleiotropic anti-inflammatory signalling actions.
   Methods and results It was hypothesized that high-fat diet (HFD)-induced inflammatory and metabolic responses, manifested by loss of glucose tolerance and vascular dysfunction, would be attenuated by systemic administration of nitrooctadecenoic acid (OA-NO2). Male C57BL/6j mice subjected to a HFD for 20 weeks displayed increased adiposity, fasting glucose, and insulin levels, which led to glucose intolerance and pulmonary hypertension, characterized by increased right ventricular (RV) end-systolic pressure (RVESP) and pulmonary vascular resistance (PVR). This was associated with increased lung xanthine oxidoreductase (XO) activity, macrophage infiltration, and enhanced expression of pro-inflammatory cytokines. Left ventricular (LV) end-diastolic pressure remained unaltered, indicating that the HFD produces pulmonary vascular remodelling, rather than LV dysfunction and pulmonary venous hypertension. Administration of OA-NO2 for the final 6.5 weeks of HFD improved glucose tolerance and significantly attenuated HFD-induced RVESP, PVR, RV hypertrophy, lung XO activity, oxidative stress, and pro-inflammatory pulmonary cytokine levels.
   Conclusions These observations support that the pleiotropic signalling actions of electrophilic fatty acids represent a therapeutic strategy for limiting the complex pathogenic responses instigated by obesity.
C1 [Kelley, Eric E.; Weidert, Eric R.] Univ Pittsburgh, Dept Anesthesiol, Pittsburgh, PA 15213 USA.
   [Kelley, Eric E.; Baust, Jeff; Cantu-Medellin, Nadiezhda; Gladwin, Mark T.; Champion, Hunter C.; Freeman, Bruce A.] Univ Pittsburgh, Vasc Med Inst, Pittsburgh, PA 15213 USA.
   [Bonacci, Gustavo; Golin-Bisello, Franca; Gor, Sonia; Freeman, Bruce A.; Khoo, Nicholas K. H.] Univ Pittsburgh, Dept Pharmacol & Chem Biol, Pittsburgh, PA 15213 USA.
   [Devlin, Jason E.; St Croix, Claudette M.; Watkins, Simon C.] Univ Pittsburgh, Ctr Biol Imaging, Pittsburgh, PA 15213 USA.
   [Frisbee, Jefferson C.] W Virginia Univ, Hlth Sci Ctr, Dept Physiol & Pharmacol, Morgantown, WV 26506 USA.
   [Gladwin, Mark T.; Champion, Hunter C.] Univ Pittsburgh, Dept Med, Pittsburgh, PA 15213 USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE); University
   of Pittsburgh; Pennsylvania Commonwealth System of Higher Education
   (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of
   Higher Education (PCSHE); University of Pittsburgh; Pennsylvania
   Commonwealth System of Higher Education (PCSHE); University of
   Pittsburgh; West Virginia University; Pennsylvania Commonwealth System
   of Higher Education (PCSHE); University of Pittsburgh
RP Freeman, BA (corresponding author), Univ Pittsburgh, Vasc Med Inst, Pittsburgh, PA 15213 USA.
EM freerad@pitt.edu; nkhoo@pitt.edu
RI Watkins, Simon/ABG-2590-2021; St Croix, Claudette/AAA-3338-2022
OI watkins, simon/0000-0003-4092-1552; Frisbee,
   Jefferson/0000-0003-2751-0599; Bonacci, Gustavo/0000-0002-9830-1850
FU Gilead Sciences Research Scholars Program in PAH; American Heart
   Association-National Scientists Development Grant [10SDG3560005];
   National Institutes of Health [UO1-HL-108642-01, R01-HL-058115,
   R01-HL-64937, PO1-HL-103455]; American Heart Association (AHA)
   [10SDG3560005] Funding Source: American Heart Association (AHA)
FX This work was supported by Gilead Sciences Research Scholars Program in
   PAH (N.K.H.K.); American Heart Association-National Scientists
   Development Grant-10SDG3560005 (E. E. K.); and National Institutes of
   Health [UO1-HL-108642-01 to H. C. C.; R01-HL-058115 and R01-HL-64937 to
   B. A. F.; and PO1-HL-103455 to N.K.H.K., C. M. S. C., H. C. C., B. A.
   F., and M.T.G.].
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NR 42
TC 78
Z9 84
U1 0
U2 16
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0008-6363
EI 1755-3245
J9 CARDIOVASC RES
JI Cardiovasc. Res.
PD MAR 1
PY 2014
VL 101
IS 3
BP 352
EP 363
DI 10.1093/cvr/cvt341
PG 12
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA AB8KW
UT WOS:000332040000005
PM 24385344
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Sakai, S
   Iizuka, N
   Fujiwara, M
   Miyoshi, M
   Aoyama, M
   Maeshige, N
   Hamada, Y
   Usami, Y
   Usami, M
AF Sakai, Shota
   Iizuka, Norihito
   Fujiwara, Mayu
   Miyoshi, Makoto
   Aoyama, Michiko
   Maeshige, Noriaki
   Hamada, Yasuhiro
   Usami, Yu
   Usami, Makoto
TI Mild obesity reduces survival and adiponectin sensitivity in endotoxemic
   rats
SO JOURNAL OF SURGICAL RESEARCH
LA English
DT Article
DE Adiponectin; Obesity; Sepsis; High-fat diet; Lipopolysaccharide
ID RECEPTOR GENE-EXPRESSION; HIGH-FAT DIET; METABOLIC SYNDROME;
   POLYMICROBIAL SEPSIS; SKELETAL-MUSCLE; MITOCHONDRIAL DYSFUNCTION;
   DEFICIENCY PROMOTES; INSULIN-RESISTANCE; OXIDATIVE STRESS; CRITICAL
   ILLNESS
AB Background: Recent meta-analyses have reported that critically ill patients with morbid obesity (body mass index >40 kg/m(2)) have poor outcomes, but the effects and mechanisms of action of mild obesity are still unclear. The purpose of this study was to evaluate the effect of mild obesity using a lard-based, high-fat diet (HFD) on pathologic conditions and the mechanisms of adiponectin action in endotoxemic rats.
   Materials and methods: Male Wistar rats underwent HFD feeding for 4 wk and were killed at 0, 1.5, and 6 h after lipopolysaccharide (LPS) injection. Plasma levels of adiponectin, nitric oxide, and interleukin 6; messenger RNA expression of adiponectin receptors (AdipoR1 and AdipoR2) in the liver and the skeletal muscle; blood biochemical test results; and histology of the liver were analyzed.
   Results: HFD-fed rats had a lower survival rate (12.8% versus 85.2%) and lower plasma adiponectin levels after LPS injection (P < 0.01). Messenger RNA expression of adiponectin receptors in the liver, but not the skeletal muscle, also decreased in HFD-fed rats (P < 0.05). Tissue injury and oxidative stress in the liver and plasma inflammatory mediator levels increased, and worsened lipid metabolism abnormalities were noted. The findings indicated that HFD decreased the sensitivity of adiponectin and was associated with an increase in oxidative stress and inflammation, which finally resulted in worsened liver injury and poor survival rate after LPS injection.
   Conclusions: Short-term, HFD-induced, mild obesity is harmful to the septic host, reduces adiponectin sensitivity, and could be the cause of worsening pathologic conditions. (C) 2013 Elsevier Inc. All rights reserved.
C1 [Sakai, Shota; Iizuka, Norihito; Fujiwara, Mayu; Miyoshi, Makoto; Aoyama, Michiko; Maeshige, Noriaki; Usami, Makoto] Kobe Univ, Grad Sch Hlth Sci, Dept Biophys, Div Nutr & Metab, Kobe, Hyogo 6540142, Japan.
   [Hamada, Yasuhiro] Univ Tokushima, Grad Sch, Dept Therapeut Nutr, Inst Hlth Biosci, Tokushima 770, Japan.
   [Usami, Yu] Osaka Univ, Dent Hosp, Clin Lab, Osaka, Japan.
   [Usami, Makoto] Kobe Univ, Sch Med, Kobe Univ Hosp, Dept Nutr, Kobe, Hyogo 650, Japan.
C3 Kobe University; Tokushima University; The University of Osaka; Kobe
   University
RP Usami, M (corresponding author), Kobe Univ, Grad Sch Hlth Sci, Dept Biophys, Div Nutr & Metab,Suma Ku, 7-10-2 Tomogaoka, Kobe, Hyogo 6540142, Japan.
EM musa@kobe-u.ac.jp
RI Maeshige, Noriaki/GRY-4152-2022; Miyoshi, Makoto/AAY-7799-2021
OI Maeshige, Noriaki/0000-0002-3573-347X
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NR 48
TC 18
Z9 19
U1 0
U2 9
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0022-4804
EI 1095-8673
J9 J SURG RES
JI J. Surg. Res.
PD NOV
PY 2013
VL 185
IS 1
BP 353
EP 363
DI 10.1016/j.jss.2013.06.002
PG 11
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 238MP
UT WOS:000325951100074
PM 23838384
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Müller-Fielitz, H
   Raasch, W
AF Mueller-Fielitz, H.
   Raasch, W.
TI Angiotensin II Impairs Glucose Utilization in Obese Zucker Rats by
   Increasing HPA Activity via an Adrenal-dependent Mechanism
SO HORMONE AND METABOLIC RESEARCH
LA English
DT Article
DE renin-angiotensin II system; obesity; insulin; stress; ACTH test;
   adrenalectomy
ID PANCREATIC BETA-CELLS; METABOLIC SYNDROME; INSULIN-RELEASE; IN-VITRO;
   STRESS SENSITIVITY; DIABETES-MELLITUS; INHIBITION; AXIS; SYSTEM;
   CORTICOSTERONE
AB Angiotensin II (AngII) increases the activity of the hypothalamus-pituitary-adrenal (HPA) axis. We have previously demonstrated in obese Zucker rats (OZR) that AngII-induced HPA hyper-reactivity was associated with impaired glucose utilization. The aim of this study was to specify the potential role of the adrenals in regulating AngII-dependent glucose homeostasis in obesity. Adrenal-specific AngII effects were determined regarding 1) the HPA axis by ACTH tests after treating OZR with AngII (9 mu g/h, s.c.) for 3 months and 2) glucose utilization by oral glucose tolerance tests (OGTT) in OZR that were adrenalectomized (adx) or sham operated and treated for 1 month with AngII (9 mu g/h, s.c.). AngII increased the corticosterone response after ACTH infusions, clearly indicating the key role of the adrenals for mediating stress reactions. Baseline levels of glucose and corticosterone were not altered by AngII treatment or by adrenalectomy. In contrast, AngII similarly reduced baseline insulin in sham and adxOZR. During OGTT, AngII increased glucose and corticosterone responses in shamOZR, whereas insulin was slightly diminished. This reaction pattern was lost when obese Zucker rats were adrenalectomized. In summary, we verified our hypothesis that the adrenal glands play a key role in worsening glucose homeostasis in obesity in response to AngII, which further supports recent findings that improvement in glucose utilization after AT(1) blockade is related to reduced activity of the HPA axis.
C1 [Mueller-Fielitz, H.; Raasch, W.] Med Univ Lubeck, Inst Expt & Clin Pharmacol & Toxicol, D-23538 Lubeck, Germany.
C3 University of Lubeck
RP Raasch, W (corresponding author), Med Univ Lubeck, Inst Expt & Clin Pharmacol & Toxicol, Ratzeburger Allee 160, D-23538 Lubeck, Germany.
EM raasch@medinf.mu-luebeck.de
RI Raasch, Walter/AAR-1165-2020
OI Muller-Fielitz, Helge/0000-0003-2815-4426
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NR 36
TC 13
Z9 13
U1 1
U2 3
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0018-5043
J9 HORM METAB RES
JI Horm. Metab. Res.
PD FEB
PY 2013
VL 45
IS 2
BP 173
EP 180
DI 10.1055/s-0032-1327679
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 090OA
UT WOS:000314987400016
PM 23104420
DA 2025-06-11
ER

PT J
AU Paternain, L
   Batlle, MA
   De la Garza, AL
   Milagro, FI
   Martínez, JA
   Campión, J
AF Paternain, L.
   Batlle, M. A.
   De la Garza, A. L.
   Milagro, F. I.
   Martinez, J. A.
   Campion, J.
TI Transcriptomic and Epigenetic Changes in the Hypothalamus Are Involved
   in an Increased Susceptibility to a High-Fat-Sucrose Diet in Prenatally
   Stressed Female Rats
SO NEUROENDOCRINOLOGY
LA English
DT Article
DE Brain; DNA methylation; Obesity; POMC; Slc6a3
ID PITUITARY-ADRENAL AXIS; INSULIN-RESISTANCE; FOOD-INTAKE;
   POSTNATAL-DEVELOPMENT; GLUCOSE-INTOLERANCE; METABOLIC SYNDROME;
   GENE-EXPRESSION; INDUCED OBESITY; METHYLATION; DOPAMINE
AB Disturbances in the prenatal period are linked to metabolic disorders in adulthood, implying the hypothalamic systems of appetite and energy balance regulation. In order to analyze the central effects of a high-fat-sucrose (HFS) diet in prenatally stressed (PNS) female adult rats, Wistar dams were exposed to chronic-mild-stress during the third week of gestation and were then compared with unstressed controls. Adult female offspring were fed a chow or HFS diet for 10 weeks. Changes in body weight, adiposity as well as expression and methylation levels of selected hypothalamic genes were analyzed. PNS induced lower birthweight and body length with no changes in body fat mass. After the HFS diet, the expected overweight model was observed accompanied by higher adiposity and insulin resistance, which was worsened by PNS. The stress model induced higher energy intake in adulthood. Hypothalamic gene expression analysis revealed that the HFS diet decreased Slc6a3 (dopamine active transporter), NPY (neuropeptide Y) and IR (insulin receptor) and increased POMC (pro-opiomelanocortin). Hypothalamic DNA methylation levels in the promoter region of Slc6a3 revealed that Slc6a3 was hypermethylated by the HFS diet in CpG site -53 bp to the transcription start site. HFS diet also hypermethylated CpG site -167 bp of the POMC promoter only in nonstressed animals. No correlations were found between gene expression and DNA methylation levels. These results imply that early-life stress in females increased predisposition to diet-induced obesity in adulthood. Copyright (C) 2012 S. Karger AG, Basel
C1 [Paternain, L.; Batlle, M. A.; De la Garza, A. L.; Milagro, F. I.; Martinez, J. A.; Campion, J.] Univ Navarra, Dept Nutr Food Sci & Physiol, ES-31008 Pamplona, Spain.
C3 University of Navarra
RP Campión, J (corresponding author), Univ Navarra, Dept Nutr Food Sci & Physiol, C Irunlarrea 1, ES-31008 Pamplona, Spain.
EM jcampion@unav.es
RI Milagro, Fermin/F-2315-2015; Paternain, Laura/AAB-3917-2020; de la
   Garza, Ana Laura/GLU-6360-2022; Martinez Hernandez, J
   Alfredo/K-8709-2014
OI de la Garza, Ana Laura/0000-0002-6049-903X; Milagro, Fermin
   I./0000-0002-3228-9916; Martinez Hernandez, J
   Alfredo/0000-0001-5218-6941; Paternain, Laura/0000-0002-1119-5232;
   Campion, Javier/0000-0002-6522-8271
FU University of Navarra [LE/97]; Carlos III Health Institute (CIBER
   project, Spain) [CB06/03/1017]; CAN (Caja de Ahorros de Navarra);
   Asociacion de Amigos de la Universidad de Navarra; IBERCAJA (Spain)
FX The authors wish to thank Linea Especial (LE/97) from the University of
   Navarra, the Carlos III Health Institute (CIBER project, Spain; grant
   CB06/03/1017) and CAN (Caja de Ahorros de Navarra) for providing the
   funding for this study and also 'Asociacion de Amigos de la Universidad
   de Navarra' and IBERCAJA (Spain) for the doctoral fellowships of A. L.
   De la Garza and L. Paternain. The authors also thank Enrique Buso
   [Unidad Central de Investigacion de la Facultad de Medicina (UCIM),
   University of Valencia, Spain] for his expert support and feedback. We
   appreciate the careful reading and correction by Alexandra Simpson and
   we are also grateful to Dr. Paul Miller from the Institute of Modern
   Languages of the University of Navarra for reviewing the English of the
   manuscript.
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NR 46
TC 56
Z9 57
U1 0
U2 24
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0028-3835
EI 1423-0194
J9 NEUROENDOCRINOLOGY
JI Neuroendocrinology
PY 2012
VL 96
IS 3
BP 249
EP 260
DI 10.1159/000341684
PG 12
WC Endocrinology & Metabolism; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology
GA 039WR
UT WOS:000311279000009
PM 22986707
DA 2025-06-11
ER

PT J
AU Lee, MY
   Wu, CM
   Yu, KH
   Chu, CS
   Lee, KT
   Sheu, SH
   Lai, WT
AF Lee, Min Y.
   Wu, Chan M.
   Yu, Kuo H.
   Chu, Chih S.
   Lee, Kun T.
   Sheu, Sheng H.
   Lai, Wen T.
TI Association between hemodynamics in the common carotid artery and
   severity of carotid atherosclerosis in patients with essential
   hypertension
SO AMERICAN JOURNAL OF HYPERTENSION
LA English
DT Article
ID INTIMA-MEDIA THICKNESS; WALL SHEAR-STRESS; METABOLIC SYNDROME; RISK;
   STIFFNESS; PLAQUE; MANIFESTATIONS; ULTRASOUND; MORTALITY; PRESSURE
AB BACKGROUND
   Carotid intima-media thickness (IMT) and plaque burden evaluated by B-mode ultrasound have been used as relevant indicators for carotid atherosclerosis. This study was aimed to investigate the relationship between hemodynamic parameters in the common carotid artery (CCA) and the severity of carotid atherosclerosis in untreated hypertensive patients.
   METHODS
   Carotid IMT and plaque burden were evaluated in bilateral CCA, bifurcations, external and internal carotid arteries using duplex ultrasound in 80 untreated hypertensive patients. The patients were divided into four groups according to plaque burden. Hemodynamic parameters of CCA, including peak and mean circumferential wall tension (CWT), tensile stress (TS), wall shear stress (WSS), and Young's elastic modulus (YEM), were calculated after measurements of internal diameter (ID), IMT, and peak and mean flow velocities of CCA. Arterial stiffness was also assessed using the brachial-ankle pulse wave velocity (baPWV).
   RESULTS
   Age, pulse pressure, creatinine, carotid IMT, and mean TS were shown to have significant differences among the four plaque groups (P < 0.05). Peak CWT and peak TS were also shown to have marginal differences. In univariate analysis, the peak and mean CWT and TS were significantly correlated with plaque score. Stepwise multiple regression analysis showed that carotid IMT, age, and peak CWT were independently associated with plaque score.
   CONCLUSIONS
   These results suggest that the CWT and TS of the CCA are associated with the severity of carotid atherosclerosis in untreated hypertensive patients. Hence, the hemodynamics of vessels may contribute to the plaque burden of low-resistance arteries.
C1 [Chu, Chih S.; Lee, Kun T.; Sheu, Sheng H.; Lai, Wen T.] Kaohsiung Med Univ Hosp, Div Cardiol, Dept Internal Med, Kaohsiung, Taiwan.
   [Lee, Min Y.; Wu, Chan M.; Yu, Kuo H.] Kaohsiung Municipal United Hosp, Div Cardiol, Dept Internal Med, Kaohsiung, Taiwan.
C3 Kaohsiung Medical University; Kaohsiung Medical University Hospital
RP Lai, WT (corresponding author), Kaohsiung Med Univ Hosp, Div Cardiol, Dept Internal Med, Kaohsiung, Taiwan.
EM wtlai@cc.kmu.edu.tw
RI Lai, Wen-Ter/D-5500-2009; Lee, Kun-Tai/D-4507-2009; Sheu,
   Sheng-Hsiung/C-7445-2009; YU, KUO/JFS-5792-2023
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NR 36
TC 21
Z9 25
U1 1
U2 7
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0895-7061
EI 1941-7225
J9 AM J HYPERTENS
JI Am. J. Hypertens.
PD JUL
PY 2008
VL 21
IS 7
BP 765
EP 770
DI 10.1038/ajh.2008.182
PG 6
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 313BR
UT WOS:000256716600014
PM 18451808
OA Bronze
DA 2025-06-11
ER

PT J
AU Anaizi, N
AF Anaizi, Nasr
TI The Impact of Uric Acid on Human Health: Beyond Gout and Kidney Stones
SO IBNOSINA JOURNAL OF MEDICINE AND BIOMEDICAL SCIENCES
LA English
DT Review
DE Uric acid; metabolism; hyperuricemia; pathogenesis of disease; oxidative
   stress; chronic inflammation; insulin resistance; essential
   hypertension; chronic kidney disease
ID OXIDATIVE STRESS; BLOOD-PRESSURE; ANTIOXIDANT; HYPERURICEMIA;
   PATHOGENESIS; HYPERTENSION; ASSOCIATION; DISEASE
AB In most primates, including humans, uric acid (UA) is the end product of purine metabolism due to the loss of hepatic uricase activity during evolution. This loss resulted in higher serum urate concentrations (3.5-7.5 mg/dL) than normally observed in other mammals (0.05-2 mg/dL). About 70% of the daily urate burden is eliminated via the kidneys and the remainder via the intestines, where gut bacteria break it down. Urate is freely filtered through the glomerular capillaries, and most of the filtered urate is reabsorbed so that only an amount equivalent to about 10% of the filtered load is excreted in the urine. Virtually all of the renal urate reabsorption takes place in proximal convoluted tubules. Many transport proteins connected with urate have been identified. However, the best studied are URAT1 and GLUT9, which function in concert to translocate urate from the proximal tubule lumen to the peritubular fluid, the first in the apical membrane and the second in the basolateral membrane. Genetic mutations, as well as drugs that alter the function of these transporters, can affect urate homeostasis resulting in abnormal serum levels, which may, in turn, be involved in the pathogenesis of chronic metabolic and inflammatory diseases, including most features of the metabolic syndrome, hypertension, cardiovascular disease, and chronic kidney disease. Several mechanisms are thought to provide the link between urate and these disorders, including reactive oxygen species (oxidative stress) and both acute and chronic inflammation. This mini-review summarizes the basic human biology of UA and its association with and potential involvement in developing chronic diseases beyond gout and nephrolithiasis.
C1 [Anaizi, Nasr] Univ Benghazi, Fac Med, Dept Physiol, Benghazi, Libya.
C3 University of Benghazi
RP Anaizi, N (corresponding author), Univ Benghazi, Fac Med, Dept Physiol, Benghazi, Libya.
EM anaizi1@gmail.com
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NR 37
TC 2
Z9 2
U1 0
U2 8
PU THIEME MEDICAL PUBL INC
PI NEW YORK
PA 333 SEVENTH AVE, NEW YORK, NY 10001 USA
SN 1947-489X
J9 IBNOSINA J MED BIOME
JI Ibnosina J. Med. Biomed. Sci.
PD SEP
PY 2023
VL 15
IS 03
BP 110
EP 116
DI 10.1055/s-0043-1770929
EA JUL 2023
PG 7
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA O5VL9
UT WOS:001029343100001
OA hybrid
DA 2025-06-11
ER

PT J
AU Bove, M
   Lama, A
   Schiavone, S
   Pirozzi, C
   Tucci, P
   Sikora, V
   Trinchese, G
   Corso, G
   Morgese, MG
   Trabace, L
AF Bove, Maria
   Lama, Adriano
   Schiavone, Stefania
   Pirozzi, Claudio
   Tucci, Paolo
   Sikora, Vladyslav
   Trinchese, Giovanna
   Corso, Gaetano
   Morgese, Maria Grazia
   Trabace, Luigia
TI Social isolation triggers oxidative status and impairs systemic and
   hepatic insulin sensitivity in normoglycemic rats
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Article
DE Insulin; Social isolation; Oxidative stress; Liver; Hypothalamus
ID NAIVE 1ST-EPISODE PATIENTS; FATTY LIVER-DISEASE; DRUG-NAIVE;
   GLUCOSE-HOMEOSTASIS; PSYCHOSOCIAL STRESS; METABOLIC SYNDROME; PREFRONTAL
   CORTEX; NADPH OXIDASES; ANIMAL-MODELS; WEIGHT-GAIN
AB Drug-naive psychotic patients show metabolic and hepatic dysfunctions. The rat social isolation model of psychosis allows to investigate mechanisms leading to these disturbances to which oxidative stress crucially contributes. Here, we investigated isolation-induced central and peripheral dysfunctions in glucose homeostasis and insulin sensitivity, along with redox dysregulation. Social isolation did not affect basal glycemic levels and the response to glucose and insulin loads in the glucose and insulin tolerance tests. However, HOMA-Index value were increased in isolated (ISO) rats. A hypothalamic reduction of AKT phosphorylation and a trend toward an increase in AMPK phosphorylation were observed following social isolation, accompanied by reduced GLUT-4 levels. Social isolation also induced a reduction of phosphorylation of the insulin receptor, of AKT and GLUT 2, and a decreased phosphorylation of AMPK in the liver. Furthermore, a significant reduction in hepatic CPT1 and PPAR-alpha levels was detected. ISO rats also showed significant elevations in hepatic ROS amount, lipid peroxidation and NOX4 expression, whereas no differences were detected in NOX2 and NOX1 levels. Expression of SOD2 in the mitochondrial fraction and SOD1 in the cytosolic fraction was not altered following social isolation, whereas SOD activity was increased. Furthermore, a decrease of hepatic CAT and GSH amount was observed in ISO rats compared to GRP animals. Our data suggest that the increased oxidant status and antioxidant capacity modifications may trigger hepatic and systemic insulin resistance, by altering signal hormone pathway and sustaining subsequent alteration of glucose homeostasis and metabolic impairment observed in the social isolation model of psychosis.
C1 [Bove, Maria; Schiavone, Stefania; Tucci, Paolo; Sikora, Vladyslav; Corso, Gaetano; Morgese, Maria Grazia; Trabace, Luigia] Univ Foggia, Dept Clin & Expt Med, Via Napoli 20, I-71122 Foggia, Italy.
   [Lama, Adriano; Pirozzi, Claudio] Univ Naples Federico II, Dept Pharm, Via Domenico Montesano 49, I-80131 Naples, Italy.
   [Sikora, Vladyslav] Sumy State Univ, Dept Pathol, 2 Rymskogo Korsakova St, UA-40007 Sumy, Ukraine.
   [Trinchese, Giovanna] Univ Naples Federico II, Dept Biol, Complesso Univ Monte St Angelo, I-80126 Naples, Italy.
C3 University of Foggia; University of Naples Federico II; Ministry of
   Education & Science of Ukraine; Sumy State University; University of
   Naples Federico II
RP Schiavone, S (corresponding author), Univ Foggia, Dept Clin & Expt Med, Via Napoli 20, I-71122 Foggia, Italy.
EM maria.bove@unifg.it; adriano.lama@unina.it; stefania.schiavone@unifg.it;
   claudio.pirozzi@unina.it; paolo.tucci@unifg.it;
   vladyslav.sikora@unifg.it; giovanna.trinchese@unina.it;
   gaetano.corso@unifg.it; mariagrazia.morgese@unifg.it;
   luigia.trabace@unifg.it
RI Giovanna, Trinchese/AAC-5995-2022; Tucci, Paolo/C-7197-2015; Trabace,
   Luigia/E-5239-2016; Sikora, Vladyslav/AAQ-1802-2020; Corso,
   Gaetano/H-9450-2013; Pirozzi, Claudio/S-2760-2016; Lama,
   Adriano/AAC-1964-2020; MORGESE, MARIA GRAZIA/AFP-4801-2022
OI MORGESE, MARIA GRAZIA/0000-0002-9887-5504; Sikora,
   Vladyslav/0000-0002-4147-6879
FU PRIN-Italian Ministry of Education, University and Research (MIUR) ,
   Italy [2017YZF7MA, 2017AY8BP4]; Italian Ministry of Education,
   University and Research (MIUR) , Italy; Research for Innovation (REFIN)
   from Apulia Region, Italy [OE9C2692]
FX This study was supported by PRIN 2017 code 2017AY8BP4 to SS from the
   Italian Ministry of Education, University and Research (MIUR) , Italy;
   PRIN 2017 code 2017YZF7MA to LT from MIUR and Research for Innovation
   (REFIN) from Apulia Region, Italy, code OE9C2692 to MB.
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NR 89
TC 10
Z9 10
U1 2
U2 8
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD MAY
PY 2022
VL 149
AR 112820
DI 10.1016/j.biopha.2022.112820
EA MAR 2022
PG 10
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA 0Z8KO
UT WOS:000791320600006
PM 35290886
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Gomes, LF
   Costa, SAM
   Rocha-Gomes, A
   Teixeira, AE
   da Silva, AA
   Lessa, MR
   Dessimoni-Pinto, NAV
   Seixas, SRS
   Riul, TR
AF Gomes, Leticia Fernandes
   Madureira Costa, Sibelle Aparecida
   Rocha-Gomes, Arthur
   Teixeira, Amanda Escobar
   da Silva, Alexandre Alves
   Lessa, Mayara Rodrigues
   Villela Dessimoni-Pinto, Nisia Andrade
   Stuckert Seixas, Sergio Ricardo
   Riul, Tania Regina
TI Cafeteria diet from birth to adulthood promotes hepatic steatosis and
   redox imbalance in Wistar rats
SO NUTRITION & FOOD SCIENCE
LA English
DT Article
DE Oxidative stress; Fatty liver; Non-alcoholic fatty liver disease;
   Western diet; Wistar rat
ID FATTY LIVER-DISEASE; HIPPOCAMPAL OXIDATIVE STRESS; METABOLIC SYNDROME;
   MODEL; EPIDEMIOLOGY; LIPOTOXICITY; PREVALENCE; DAMAGE; NAFLD
AB Purpose The purpose of this paper is to evaluate the pathological, biochemical and redox state parameters of liver tissue in Wistar rats treated from birth to adulthood (119 days) with cafeteria diet. Design/methodology/approach During the lactation, 6 liters of Wistar rats (dam + 8 pups each) were fed one of two diets: control (CTRL;n= 3) or cafeteria (CAF;n= 3) diets and water ad libitum. After weaning, the males were placed in individual cages, receiving the same diet offered to their respective dams (CTRL or CAF;n= 18) until adulthood. The following parameters were evaluated: absolute and relative liver weight; blood, liver and feces biochemistry; liver histology; and redox state of the liver. Findings When assessing the relative and absolute organ weight, no significant differences were found between the groups. The Cafeteria group exhibited higher values of serum LDL-c (p= 0.008), VLDL-c (p= 0.03) and triglycerides (p= 0.01), as well as several micro and macrovacuoles of fat accumulation, higher hepatic lipid (p= 0.03) and cholesterol (p= 0.0001) levels regarding Control group. Cafeteria group showed greater expression of glutathione-s-transferase (p= 0.03) and superoxide dismutase (p= 0.005) enzymes compared to the control group. In the case of the markers of oxidative stress, there was no difference between the groups. Originality/value A simple and standardized cafeteria diet caused an accumulation of fatty acids in liver tissue, inducing a state of hepatic steatosis besides an increased expression of antioxidant enzymes.
C1 [Gomes, Leticia Fernandes; Madureira Costa, Sibelle Aparecida; Rocha-Gomes, Arthur; Teixeira, Amanda Escobar; da Silva, Alexandre Alves; Lessa, Mayara Rodrigues; Villela Dessimoni-Pinto, Nisia Andrade; Stuckert Seixas, Sergio Ricardo; Riul, Tania Regina] Univ Fed Vales Jequitinhonha & Mucuri, Diamantina, Brazil.
C3 Universidade Federal dos Vales do Jequitinhonha e Mucuri (UFVJM)
RP Riul, TR (corresponding author), Univ Fed Vales Jequitinhonha & Mucuri, Diamantina, Brazil.
EM taniriul@yahoo.com.br
RI Andrade, Nísia/AAH-2974-2021
OI Dessimoni Pinto, Nisia Andrade/0000-0002-7485-3757; Rocha Gomes,
   Arthur/0000-0002-2494-3113
FU Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior - Brasil
   (CAPES) [001]
FX This study was financed by the Coordenacao de Aperfeicoamento de Pessoal
   de Nivel Superior - Brasil (CAPES; Financial Code 001).
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NR 48
TC 5
Z9 5
U1 0
U2 5
PU EMERALD GROUP PUBLISHING LTD
PI Leeds
PA Floor 5, Northspring 21-23 Wellington Street, Leeds, W YORKSHIRE,
   ENGLAND
SN 0034-6659
EI 1758-6917
J9 NUTR FOOD SCI
JI Nutr. Food Sci.
PD MAY 6
PY 2021
VL 51
IS 3
BP 483
EP 493
DI 10.1108/NFS-05-2020-0191
EA JUL 2020
PG 11
WC Food Science & Technology
WE Emerging Sources Citation Index (ESCI)
SC Food Science & Technology
GA RX4QI
UT WOS:000556906400001
DA 2025-06-11
ER

PT J
AU Kim, GR
   Jee, SH
   Pikhart, H
AF Kim, Gyu Ri
   Jee, Sun Ha
   Pikhart, Hynek
TI Role of allostatic load and health behaviours in explaining
   socioeconomic disparities in mortality: a structural equation modelling
   approach
SO JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH
LA English
DT Article
DE socioeconomic inequalities; mortality; structural equation modelling;
   allostatic load; biomarkers; stress; health behaviour
ID CUMULATIVE BIOLOGICAL RISK; MACARTHUR; STRESS; BIOMARKERS; DISEASE;
   DISADVANTAGE; POPULATION; RESPONSES; POSITION; COHORT
AB Background The relationship between socioeconomic status and mortality has been well established; however, the extent to which biological factors mediate this relationship is less clear, and empirical evidence from non-Western settings is limited. Allostasis, a cumulative measure of physiological dysregulation, has been proposed as the underlying mechanism linking socioeconomic status to adverse health outcomes. The current study aimed to ascertain the contribution of allostatic load (AL) and health behaviours to socioeconomic inequalities in mortality among Korean adults.
   Methods The sample comprised 70713 middle-aged and older-aged adults, aged 40-79 years from the Korean Metabolic Syndrome Mortality Study. Using structural equation modelling (SEM), mediation analyses were performed to estimate the effects of socioeconomic position (SEP) on mortality over the follow-up and the extent to which AL, physical exercise and non-smoking status mediate the association between SEP and mortality.
   Results A total of 5618 deaths (7.9%) occurred during the mean follow-up of 15.2 years (SD 2.9). SEM confirmed a direct significant effect of SEP on mortality, as well as significant indirect paths through AL, physical exercise and non-smoking status.
   Conclusions Our findings provide support for the mediating role of AL and health behaviours in the link between SEP and mortality. Policies designed to reduce social disparities in mortality in the long term should primarily focus on reducing stress and promoting healthy lifestyles among the socially disadvantaged groups. Future studies should further assess the role of other mediators such as psychosocial factors, which may contribute to socioeconomic inequalities in mortality.
C1 [Kim, Gyu Ri] Yonsei Univ, Grad Sch Publ Hlth, Dept Biostat, Seoul, South Korea.
   [Jee, Sun Ha] Yonsei Univ, Grad Sch Publ Hlth, Dept Epidemiol & Hlth Promot, Seoul, South Korea.
   [Jee, Sun Ha] Yonsei Univ, Grad Sch Publ Hlth, Inst Hlth Promot, Seoul, South Korea.
   [Pikhart, Hynek] UCL, Dept Epidemiol & Publ Hlth, London, England.
C3 Yonsei University; Yonsei University Health System; Yonsei University;
   Yonsei University Health System; Yonsei University; Yonsei University
   Health System; University of London; University College London
RP Jee, SH (corresponding author), Yonsei Univ, Grad Sch Publ Hlth, Dept Epidemiol & Hlth Promot, Seoul, South Korea.; Jee, SH (corresponding author), Yonsei Univ, Grad Sch Publ Hlth, Inst Hlth Promot, Seoul, South Korea.
EM jsunha@yuhs.ac
RI Wang, Zhe/AGZ-4159-2022; Pikhart, Hynek/E-3074-2010
OI Pikhart, Hynek/0000-0001-5277-4049; Jee, Sun Ha/0000-0001-9519-3068;
   Kim, Gyu Ri/0000-0003-3624-3971
FU Korean Health Technology R&D Project, Ministry of Health & Welfare,
   Republic of Korea [HI14C2686]
FX The Korean Metabolic Syndrome Mortality Study is supported by the grant
   from the Korean Health Technology R&D Project, Ministry of Health &
   Welfare, Republic of Korea (HI14C2686).
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NR 39
TC 16
Z9 19
U1 1
U2 15
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 0143-005X
EI 1470-2738
J9 J EPIDEMIOL COMMUN H
JI J. Epidemiol. Community Health
PD JUN
PY 2018
VL 72
IS 6
BP 545
EP 551
DI 10.1136/jech-2017-209131
PG 7
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA GH2ON
UT WOS:000433241300017
PM 29459378
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Schenk, HM
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   de Jonge, P
   Rosmalen, JGM
AF Schenk, Hendrika M.
   Jeronimus, Bertus F.
   van der Krieke, Lian
   Bos, Elisabeth H.
   de Jonge, Peter
   Rosmalen, Judith G. M.
TI Associations of Positive Affect and Negative Affect With Allostatic
   Load: A Lifelines Cohort Study
SO PSYCHOSOMATIC MEDICINE
LA English
DT Article
DE positive affect; negative affect; allostatic load; cohort study;
   biological markers; health
ID CORONARY-HEART-DISEASE; SELF-REPORTED HEALTH; ALCOHOL-CONSUMPTION;
   GENDER-DIFFERENCES; METABOLIC SYNDROME; PHYSICAL-ACTIVITY; AFFECT
   SCHEDULE; STRESS; RISK; CORTISOL
AB Objective Allostatic load (AL) reflects the deteriorating influences of stress on the body and comprises a selection of biological markers. AL is associated with negative life events, stress, and negative affect (NA), as well as poor health outcomes. However, whether AL is also associated with positive affect (PA) is not clear. The present study therefore explores the association between PA and AL, accounting for age, sex, NA, and health behaviors.
   Methods Data of 45,225 individuals from the first wave of the multidisciplinary prospective population-based cohort study Lifelines were used. AL was operationalized as the sum of 12 inflammatory, cardiovascular, and metabolic markers. The association between PA and AL was tested in a cross-sectional study design using multiple linear regression analysis, adjusting for NA, confounders, and health behaviors. In addition, we explored whether the relation was moderated by age, sex, and NA.
   Results The AL profile was inversely associated with PA (B = -0.083, p < .001) when adjusted for NA, age, and sex. The association between AL and PA remained significant after adjusting for health behaviors (B = -0.076, p < .001). A significant moderating effect was found for sex (PA by sex: B = 0.046, p = .001), indicating that the association between PA and AL was stronger in women than in men.
   Conclusions PA was associated with a more favorable AL profile, especially in women. These results add to the evidence that PA might be of relevance to the etiology of disease.
C1 [Schenk, Hendrika M.; Jeronimus, Bertus F.; van der Krieke, Lian; Bos, Elisabeth H.; de Jonge, Peter; Rosmalen, Judith G. M.] Univ Groningen, Univ Med Ctr Groningen, Interdisciplinary Ctr Psychopathol & Emot Regulat, Groningen, Netherlands.
   [Jeronimus, Bertus F.; Bos, Elisabeth H.; de Jonge, Peter] Univ Groningen, Dept Dev Psychol, Groningen, Netherlands.
C3 University of Groningen; University of Groningen
RP Schenk, HM (corresponding author), Hanzeplein 1,CC72, NL-9700 RB Groningen, Netherlands.
EM hmschenk@gmail.com
RI Jeronimus, Bertus/AAC-2877-2020; de Jonge, Peter/L-6395-2013; Rosmalen,
   Judith/F-5375-2011
OI de Jonge, Peter/0000-0002-0866-6929; Rosmalen,
   Judith/0000-0002-6393-0032; Jeronimus, Bertus/0000-0003-2826-4537;
   Schenk, H. Maria/0000-0002-2799-0265
FU Espria Academy
FX This work was supported by the Espria Academy. Espria is a health care
   group in the Netherlands consisting of multiple companies targeted
   mainly at the elderly population. The authors have no conflict of
   interests to declare.
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NR 71
TC 33
Z9 38
U1 0
U2 16
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0033-3174
EI 1534-7796
J9 PSYCHOSOM MED
JI Psychosom. Med.
PD FEB-MAR
PY 2018
VL 80
IS 2
BP 160
EP 166
DI 10.1097/PSY.0000000000000546
PG 7
WC Psychiatry; Psychology; Psychology, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry; Psychology
GA FV8ZE
UT WOS:000424875700004
PM 29215457
OA Green Published
DA 2025-06-11
ER

PT J
AU Schosserer, M
   Grillari, J
   Wolfrum, C
   Scheideler, M
AF Schosserer, Markus
   Grillari, Johannes
   Wolfrum, Christian
   Scheideler, Marcel
TI Age-Induced Changes in White, Brite, and Brown Adipose Depots: A
   Mini-Review
SO GERONTOLOGY
LA English
DT Review
DE Aging; Adipose tissue; Oxidative stress; Cellular senescence; Metabolic
   disease
ID MESENCHYMAL STEM-CELLS; INSULIN-RESISTANCE; LIFE-SPAN; ADIPOGENIC
   DIFFERENTIATION; LIMB FAT; BODY-FAT; TISSUE; METFORMIN; RECEPTOR;
   OBESITY
AB Aging is a time-related process of functional decline at organelle, cellular, tissue, and organismal level that ultimately limits life. Cellular senescence is a state of permanent growth arrest in response to stress and one of the major drivers of aging and age-related disorders. Senescent cells accumulate with age, and removal of these cells delays age-related disorders in different tissues and prolongs healthy lifespan. One of the most studied aging mechanisms is the accumulation of reactive oxygen species damage in cells, organs, and organisms over time. Elevated oxidative stress is also found in metabolic diseases such as obesity, metabolic syndrome and associated disorders. Moreover, dysregulation of the energy homeostasis is also associated with aging, and many age-related genes also control energy metabolism, with the adipose organ, comprising white, brite, and brown adipocytes, as an important metabolic player in the regulation of whole-body energy homeostasis. This review summarizes transformations in the adipose organ upon aging and cellular senescence and sheds light on the reallocation of fat mass between adipose depots, on the metabolism of white and brown adipose tissue, on the regenerative potential and adipogenic differentiation capacity of preadipocytes, and on alterations in mitochondria and bioenergetics. In conclusion, the aging process is a lifelong, creeping process with gradual decline in (pre-) adipocyte function over time. Thus, slowing down the accumulation of (pre-) adipocyte damage and dysfunction, removal of senescent preadipocytes as well as blocking deleterious compounds of the senescent secretome are protective measures to maintain a lasting state of health at old age. (C) 2017 S. Karger AG, Basel.
C1 [Schosserer, Markus; Grillari, Johannes] Univ Nat Resources & Life Sci, Dept Biotechnol, Vienna, Austria.
   [Grillari, Johannes] Christian Doppler Lab Biotechnol Skin Aging, Vienna, Austria.
   [Grillari, Johannes] Evercyte GmbH, Vienna, Austria.
   [Wolfrum, Christian] Swiss Fed Inst Technol, Dept Hlth Sci & Technol, Zurich, Switzerland.
   [Scheideler, Marcel] Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, IDC, Ingolstadter Landstr 1, DE-85764 Neuherberg, Germany.
   [Scheideler, Marcel] Heidelberg Univ Hosp, Joint Heidelberg IDC Translat Diabet Program, Heidelberg, Germany.
   [Scheideler, Marcel] German Ctr Diabet Res DZD, Neuherberg, Germany.
C3 BOKU University; Swiss Federal Institutes of Technology Domain; ETH
   Zurich; Helmholtz Association; Helmholtz-Center Munich - German Research
   Center for Environmental Health; Ruprecht Karls University Heidelberg;
   German Center for Diabetes Research (DZD)
RP Scheideler, M (corresponding author), Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, IDC, Ingolstadter Landstr 1, DE-85764 Neuherberg, Germany.
EM marcel.scheideler@helmholtz-muenchen.de
RI Schosserer, Markus/A-5966-2010; Scheideler, Marcel/B-3087-2015;
   Grillari, Johannes/B-2967-2011
OI Schosserer, Markus/0000-0003-2025-0739; Scheideler,
   Marcel/0000-0003-4650-7387; Grillari, Johannes/0000-0001-5474-6332;
   Wolfrum, Christian/0000-0002-3862-6805
FU German Center for Diabetes Research (DZD); European Training Network
   TRAIN [721532]; Austrian Science Fund [FWF: I2514]; Austrian Federal
   Ministry of Science, Research and Economy; National Foundation for
   Research, Technology and Development; Christian Doppler Research
   Society; Swiss National Funding Agency (SNF); Austrian Science Fund
   (FWF) [I2514] Funding Source: Austrian Science Fund (FWF)
FX This work was supported by the German Center for Diabetes Research
   (DZD), the European Training Network TRAIN (grant No. 721532), the
   Austrian Science Fund (FWF: I2514), the Austrian Federal Ministry of
   Science, Research and Economy, the National Foundation for Research,
   Technology and Development, the Christian Doppler Research Society, and
   the Swiss National Funding Agency (SNF). Parts of both figures were
   produced using Servier Medical Art. We apologize for the omission of
   relevant works due to space constraints.
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NR 63
TC 74
Z9 82
U1 0
U2 13
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0304-324X
EI 1423-0003
J9 GERONTOLOGY
JI Gerontology
PY 2018
VL 64
IS 3
BP 229
EP 236
DI 10.1159/000485183
PG 8
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA GB9EZ
UT WOS:000429378200002
PM 29212073
DA 2025-06-11
ER

PT J
AU Kotani, K
   Tsuzaki, K
   Sakane, N
AF Kotani, Kazuhiko
   Tsuzaki, Kokoro
   Sakane, Naoki
TI The Relationship Between Gamma-Glutamyltransferase (GGT), Bilirubin
   (Bil) and Small Dense Low-Density Lipoprotein (sdLDL) in Asymptomatic
   Subjects Attending a Clinic for Screening Dyslipidaemias
SO ANNALS ACADEMY OF MEDICINE SINGAPORE
LA English
DT Article
DE Atherosclerosis; LDL particle size; Oxidative stress; gamma GT; Total
   bilirubin
ID INSULIN-RESISTANCE; METABOLIC SYNDROME; SERUM BILIRUBIN;
   CARDIOVASCULAR-DISEASE; OXIDATIVE STRESS; RISK; BIOMARKERS
AB Introduction: Gamma-glutamyltransferase (GGT), bilirubin (Bil) and small dense low-density lipoprotein (sdLDL) particles are each known to be risk markers for cardiometabolic diseases which are characterised by oxidative stress conditions. These markers are connected with the oxidative milieu; however, the association between GGT, Bil, and sdLDL has been hardly examined. This hospital-based study investigated the association between GGT and sdLDL, as well as the association between Bil and sdLDL, in asymptomatic subjects. Materials and Methods: Cardiometabolic variables, GGT, Bil and the mean LDL particle size were measured in 100 asymptomatic subjects attending a clinic for screening dyslipidaemias (36 men and 64 women, mean age 64 years). Correlation analyses of the association between the mean LDL particle size and other variables, such as GGT and Bil, were performed. Results: The mean (standard deviation) levels of GGT, Bil, and the mean LDL particle size were found to be 21.7 (8.3) IU/L, 14.0 (4.3) mu mol/L, and 26.7 (0.6) nm, respectively. An univariate correlation test showed both a significant inverse correlation between the mean LDL particle size and GGT (r = 0.33, P <0.01) and a significant positive correlation between the mean LDL particle size and Bil (r = 0.32,P <0.01). A multiple regression analysis revealed similarly significant results of their correlations, independent of the other cardiometabolic variables. Conclusion: These results suggest that the correlation of GGT and sdLDL, as well as that of Bil and sdLDL, may be cooperatively associated with cardiometabolic processes. Further research is warranted in order to confirm the observed association.
C1 [Kotani, Kazuhiko; Tsuzaki, Kokoro; Sakane, Naoki] Natl Hosp Org Kyoto Med Ctr, Clin Res Inst, Div Prevent Med, Kyoto 6128555, Japan.
   [Kotani, Kazuhiko] Jichi Med Univ, Dept Clin Lab Med, Shimotsuke, Tochigi, Japan.
C3 Jichi Medical University
RP Kotani, K (corresponding author), Natl Hosp Org Kyoto Med Ctr, Clin Res Inst, Dept Prevent Med, Fushimi Ku, 1-1 Fukakusa Mukaihata, Kyoto 6128555, Japan.
EM kazukotani@jichi.ac.jp
FU Scientific Research from the Ministries of Education, Culture, Sports,
   Science, and Technology of Japan
FX This study was supported in part by a Grant-in-Aid for Scientific
   Research from the Ministries of Education, Culture, Sports, Science, and
   Technology of Japan.
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NR 21
TC 7
Z9 7
U1 0
U2 5
PU ACAD MEDICINE SINGAPORE
PI REPUBLIC SINGAPORE
PA 142 NEIL RD, REPUBLIC SINGAPORE 088871, SINGAPORE
SN 0304-4602
J9 ANN ACAD MED SINGAP
JI Ann. Acad. Med. Singap.
PD APR
PY 2014
VL 43
IS 4
BP 216
EP 219
PG 4
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA AI0CI
UT WOS:000336513400004
PM 24833073
DA 2025-06-11
ER

PT J
AU Ohtake, M
   Hattori, T
   Murase, T
   Takahashi, K
   Takatsu, M
   Ohtake, M
   Miyachi, M
   Watanabe, S
   Cheng, XW
   Murohara, T
   Nagata, K
AF Ohtake, Masafumi
   Hattori, Takuya
   Murase, Tamayo
   Takahashi, Keiji
   Takatsu, Miwa
   Ohtake, Mayuko
   Miyachi, Masaaki
   Watanabe, Shogo
   Cheng, Xian Wu
   Murohara, Toyoaki
   Nagata, Kohzo
TI GLUCOCORTICOIDS ACTIVATE CARDIAC MINERALOCORTICOID RECEPTORS IN
   ADRENALECTOMIZED DAHL SALT-SENSITIVE RATS
SO NAGOYA JOURNAL OF MEDICAL SCIENCE
LA English
DT Article
DE glucocorticoids; mineralocorticoid receptor; diastolic function;
   oxidative stress; inflammation
ID HEART-FAILURE; HYPERTENSIVE-RATS; OXIDATIVE STRESS;
   DAHLS.Z-LEPR(FA)/LEPR(FA) RATS; INFLAMMATORY RESPONSES; VENTRICULAR
   MYOCYTES; METABOLIC SYNDROME; ANIMAL-MODEL; NITRIC-OXIDE; HYPERTROPHY
AB We previously showed that selective mineralocorticoid receptor (MR) blockade by eplerenone is cardioprotective in Dahl salt-sensitive (DS) rats. To clarify the consequences of glucocorticoid-mediated MR activation in these animals, we investigated the effects of exogenous corticosterone on blood pressure as well as cardiac remodeling and function after adrenalectomy. DS rats were subjected to adrenalectomy at 6 weeks of age and thereafter fed a high-salt diet and administered corticosterone (20 mg/kg per day) or vehicle. Systolic blood pressure was higher in the corticosterone group than in the vehicle group at 7 weeks and thereafter. By 11 weeks, corticosterone had reduced left ventricular (LV) mass and induced LV diastolic dysfunction. The ratio of collagen type I to type III mRNA levels in the left ventricle was increased in the corticosterone group compared with the vehicle group. Administration of a non-antihypertensive dose of the MR antagonist spironolactone (20 mg/kg per day) from 6 weeks inhibited the effects of corticosterone on both the collagen type I to type III mRNA ratio and diastolic function without affecting the decrease in LV mass. Spironolactone attenuated both the increase in NADPH oxidase activity in the left ventricle and coronary vascular inflammatory responses apparent in the corticosterone group. These results indicate that exogenous glucocorticoids induce hypertension, cardiac remodeling, and diastolic dysfunction in adrenalectomized DS rats fed a high-salt diet. The cardiac effects of exogenous glucocorticoids are likely attributable, at least in part, to myocardial oxidative stress and coronary vascular inflammation induced by glucocorticoid-activated MRs..
C1 [Ohtake, Masafumi; Hattori, Takuya; Murase, Tamayo; Takahashi, Keiji; Takatsu, Miwa; Ohtake, Mayuko; Miyachi, Masaaki; Watanabe, Shogo; Nagata, Kohzo] Nagoya Univ, Grad Sch Med, Dept Pathophysiol Lab Sci, Nagoya, Aichi 4618673, Japan.
   [Cheng, Xian Wu; Murohara, Toyoaki] Nagoya Univ, Grad Sch Med, Dept Cardiol, Nagoya, Aichi 4618673, Japan.
C3 Nagoya University; Nagoya University
RP Nagata, K (corresponding author), Nagoya Univ, Grad Sch Med, Dept Pathophysiol Lab Sci, Higashi Ku, 1-1-20 Daikominami, Nagoya, Aichi 4618673, Japan.
EM nagata@met.nagoya-u.ac.jp
RI Murohara, Toyoaki/M-4958-2014
FU Banyu Pharmaceutical Co. Ltd. (Tokyo, Japan); Mitsubishi Tanabe Pharma
   Corporation (Osaka, Japan)
FX Source of Funding: This work was supported by unrestricted research
   grants from Banyu Pharmaceutical Co. Ltd. (Tokyo, Japan) and Mitsubishi
   Tanabe Pharma Corporation (Osaka, Japan), and by Management Expenses
   Grants from the government to Nagoya University.
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NR 43
TC 10
Z9 13
U1 0
U2 2
PU NAGOYA UNIV, SCH MED
PI NAGOYA
PA EDITORIAL OFF, NAGOYA UNIV MED LIB, SCH MED, 65 TSURUMAI-CHO SHOWA- KU,
   NAGOYA, 466-8550, JAPAN
SN 2186-3326
EI 0027-7622
J9 NAGOYA J MED SCI
JI Nagoya J. Med. Sci.
PD FEB
PY 2014
VL 76
IS 1-2
BP 59
EP 72
PG 14
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA AB8DI
UT WOS:000332019900007
PM 25129992
DA 2025-06-11
ER

PT S
AU Reynolds, LP
   Borowicz, PP
   Palmieri, C
   Grazul-Bilska, AT
AF Reynolds, Lawrence P.
   Borowicz, Pawel P.
   Palmieri, Chiara
   Grazul-Bilska, Anna T.
BE Zhang, L
   Ducsay, CA
TI Placental Vascular Defects in Compromised Pregnancies: Effects of
   Assisted Reproductive Technologies and Other Maternal Stressors
SO ADVANCES IN FETAL AND NEONATAL PHYSIOLOGY
SE Advances in Experimental Medicine and Biology
LA English
DT Article; Proceedings Paper
CT 40th Anniversary Symposium of Center for Perinatal Biology
CY FEB 11, 2013
CL Loma Linda Univ, Loma Linda, CA
SP Ctr Perinatal Biol
HO Loma Linda Univ
DE Placenta; Vascular defects; Angiogenesis; Vascular function; Pregnancy;
   Intrauterine growth restriction; Maternal stressors; Assisted
   reproductive technologies; Embryo transfer; In vitro fertilization;
   Cloning; Clones
ID CELL NUCLEAR TRANSFER; INTRAUTERINE GROWTH RESTRICTION; IN-VITRO
   FERTILIZATION; ANGIOGENIC FACTORS; METABOLIC SYNDROME;
   FETAL-DEVELOPMENT; PATHOLOGICAL IMPLICATIONS; GLOBAL METHYLATION; BOVINE
   PREGNANCIES; ADOLESCENT SHEEP
AB Many factors negatively affect pregnancy establishment and subsequent fetal growth and development, including maternal factors such as nutritional stress, age, body mass index, and genetic background, and external factors including environmental stress, psychosocial stress, multiple fetuses, medical conditions (e.g., polycystic ovary syndrome), lifestyle choices (e.g., alcohol consumption, smoking), and assisted reproductive technologies. These same factors have similar consequences for placental growth and development, including vascular development. We and others have shown that placental vascular development begins very early in pregnancy and determines, to a large extent, placental function-that is, the magnitude of the increase in placental blood flow and thus nutrient transport to the fetus. During the peri-implantation period and also later in pregnancy, cloned (somatic cell nuclear transfer) embryos exhibit a variety of placental defects including reduced vascularization and altered expression of angiogenic factors. Although placental defects are less pronounced in pregnancies resulting from the transfer of in vitro fertilized embryos, we and others have recently demonstrated that vascularization, expression of angiogenic factors, sex steroid receptors, several epigenetic markers, and growth of utero-placental tissues all were altered during early pregnancy after transfer of embryos obtained through natural mating, in vitro fertilization, or other assisted reproductive techniques. These observations are in agreement with the recent reports that in humans even singleton pregnancies established with assisted reproductive techniques are at increased risk of preterm delivery and low birth weight, and seem especially relevant considering the rapidly expanding use of these techniques in humans and animals.
C1 [Reynolds, Lawrence P.; Borowicz, Pawel P.; Grazul-Bilska, Anna T.] N Dakota State Univ, Ctr Nutr & Pregnancy, Fargo, ND 58105 USA.
   [Reynolds, Lawrence P.; Borowicz, Pawel P.; Grazul-Bilska, Anna T.] N Dakota State Univ, Dept Anim Sci, Fargo, ND 58108 USA.
   [Palmieri, Chiara] Univ Queensland, Sch Vet Sci, Gatton, Qld 4343, Australia.
C3 North Dakota State University Fargo; North Dakota State University
   Fargo; University of Queensland
RP Reynolds, LP (corresponding author), N Dakota State Univ, Ctr Nutr & Pregnancy, Fargo, ND 58105 USA.
EM Larry.Reynolds@ndsu.edu
RI Palmieri, Chiara/J-4003-2013; Reynolds, Lawrence/I-5267-2015
OI Palmieri, Chiara/0000-0002-5791-6066; Reynolds,
   Lawrence/0000-0002-6838-7809
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NR 95
TC 28
Z9 30
U1 1
U2 12
PU SPRINGER
PI NEW YORK
PA 233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES
SN 0065-2598
EI 2214-8019
BN 978-1-4939-1031-1; 978-1-4939-1030-4
J9 ADV EXP MED BIOL
JI Adv.Exp.Med.Biol.
PY 2014
VL 814
BP 193
EP 204
DI 10.1007/978-1-4939-1031-1_17
PG 12
WC Developmental Biology; Medicine, Research & Experimental; Obstetrics &
   Gynecology
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Developmental Biology; Research & Experimental Medicine; Obstetrics &
   Gynecology
GA BC4EG
UT WOS:000352355400019
PM 25015812
DA 2025-06-11
ER

PT J
AU Bakrim, S
   Aboulaghras, S
   El Menyiy, N
   El Omari, N
   Assaggaf, H
   Lee, LH
   Montesano, D
   Gallo, M
   Zengin, G
   AlDhaheri, Y
   Bouyahya, A
AF Bakrim, Saad
   Aboulaghras, Sara
   El Menyiy, Naoual
   El Omari, Nasreddine
   Assaggaf, Hamza
   Lee, Learn-Han
   Montesano, Domenico
   Gallo, Monica
   Zengin, Gokhan
   AlDhaheri, Yusra
   Bouyahya, Abdelhakim
TI Phytochemical Compounds and Nanoparticles as Phytochemical Delivery
   Systems for Alzheimer's Disease Management
SO MOLECULES
LA English
DT Review
DE Alzheimer's disease; neuroinflammation; bioactive compound; nano-drugs
ID OXIDATIVE STRESS; LOADED NANOPARTICLES; POTENTIAL USE;
   ACETYLCHOLINESTERASE-INHIBITORS; MITOCHONDRIAL DYSFUNCTION; COGNITIVE
   DEFICITS; METABOLIC SYNDROME; DOWN-REGULATION; MUSIC-THERAPY; MOUSE
   MODEL
AB Alzheimer's disease remains one of the most widespread neurodegenerative reasons for dementia worldwide and is associated with considerable mortality and morbidity. Therefore, it has been considered a priority for research. Indeed, several risk factors are involved in the complexity of the therapeutic ways of this pathology, including age, traumatic brain injury, genetics, exposure to aluminum, infections, diabetes, vascular diseases, hypertension, dyslipidemia, and obesity. The pathophysiology of Alzheimer's disease is mostly associated with hyperphosphorylated protein in the neuronal cytoplasm and extracellular plaques of the insoluble beta-amyloid peptide. Therefore, the management of this pathology needs the screening of drugs targeting different pathological levels, such as acetylcholinesterase (AchE), amyloid beta formation, and lipoxygenase inhibitors. Among the pharmacological strategies used for the management of Alzheimer's disease, natural drugs are considered a promising therapeutic strategy. Indeed, bioactive compounds isolated from different natural sources exhibit important anti-Alzheimer effects by their effectiveness in promoting neuroplasticity and protecting against neurodegeneration as well as neuroinflammation and oxidative stress in the brain. These effects involve different sub-cellular, cellular, and/or molecular mechanisms, such as the inhibition of acetylcholinesterase (AchE), the modulation of signaling pathways, and the inhibition of oxidative stress. Moreover, some nanoparticles were recently used as phytochemical delivery systems to improve the effects of phytochemical compounds against Alzheimer's disease. Therefore, the present work aims to provide a comprehensive overview of the key advances concerning nano-drug delivery applications of phytochemicals for Alzheimer's disease management.
C1 [Bakrim, Saad] Ibn Zohr Univ, Polydisciplinary Fac Taroudant, Geobioenvironm Engn & Innovat Lab, Mol Engn Biotechnol & Innovat Team, Agadir 80000, Morocco.
   [Aboulaghras, Sara] Mohammed V Univ Rabat, Fac Sci, Physiol & Physiopathol Team, Genom Human Pathol Res, Rabat 10100, Morocco.
   [El Menyiy, Naoual] Natl Agcy Med & Aromat Plants, Lab Pharmacol, Taounate 34025, Morocco.
   [El Omari, Nasreddine] Mohammed V Univ Rabat, Fac Med & Pharm, Lab Histol Embryol & Cytogenet, Rabat 10100, Morocco.
   [Assaggaf, Hamza] Umm Al Qura Univ, Fac Appl Med Sci, Dept Lab Med, Mecca 21955, Saudi Arabia.
   [Lee, Learn-Han] Monash Univ Malaysia, Jeffrey Cheah Sch Med & Hlth Sci, Novel Bacteria & Drug Discovery Res Grp NBDD, Microbiome & Bioresource Res Strength MBRS, Subang Jaya 47500, Malaysia.
   [Montesano, Domenico] Univ Naples Federico II, Dept Pharm, Via D Montesano 49, I-80131 Naples, Italy.
   [Gallo, Monica] Univ Naples Federico II, Dept Mol Med & Med Biotechnol, Via Pansini 5, I-80131 Naples, Italy.
   [Zengin, Gokhan] Selcuk Univ, Sci Fac, Dept Biol, TR-42130 Konya, Turkey.
   [AlDhaheri, Yusra] United Arab Emirates Univ, Coll Sci, Dept Biol, Al Ain 15551, U Arab Emirates.
   [Bouyahya, Abdelhakim] Mohammed V Univ Rabat, Fac Sci, Dept Biol, Lab Human Pathol Biol, Rabat 10106, Morocco.
C3 Ibn Zohr University of Agadir; Mohammed V University in Rabat; Mohammed
   V University in Rabat; Ibn sina University Hospital Center of Rabat; Umm
   Al-Qura University; Monash University; Monash University Malaysia;
   University of Naples Federico II; University of Naples Federico II;
   Selcuk University; United Arab Emirates University; Mohammed V
   University in Rabat
RP Zengin, G (corresponding author), Selcuk Univ, Sci Fac, Dept Biol, TR-42130 Konya, Turkey.; AlDhaheri, Y (corresponding author), United Arab Emirates Univ, Coll Sci, Dept Biol, Al Ain 15551, U Arab Emirates.; Bouyahya, A (corresponding author), Mohammed V Univ Rabat, Fac Sci, Dept Biol, Lab Human Pathol Biol, Rabat 10106, Morocco.
EM gokhanzengin@selcuk.edu.tr; yusra.aldhaheri@uaeu.ac.ae;
   a.bouyahya@um5r.ac.ma
RI El Omari, Nasreddine/ABG-6138-2021; BAKRIM, SAAD/HPC-6347-2023;
   Abdelhakim, BOUYAHYA/Y-5725-2019; Lee, Learn-Han/I-5331-2015; Assaggaf,
   Hamza/AAR-5861-2021; montesano, domenico/O-2391-2018; Zengin,
   Gokhan/K-9393-2015
OI GALLO, Monica/0000-0001-6281-426X; EL MENYIY,
   Naoual/0000-0002-4842-2056; ABOULAGHRAS, SARA/0009-0004-3298-8145; Lee,
   Learn-Han/0000-0002-8589-7456; Assaggaf, Hamza/0000-0001-5563-9491;
   Saad, Bakrim/0000-0002-4521-3515; montesano,
   domenico/0000-0002-8857-2091; El Omari, Nasreddine/0000-0002-0308-1155;
   Zengin, Gokhan/0000-0001-6548-7823
FU Deanship for Research & Innovation, Ministry of Education in Saudi
   Arabia;  [IFP22UQU4310026DSR006]
FX This research received no external funding.
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NR 174
TC 11
Z9 11
U1 2
U2 21
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1420-3049
J9 MOLECULES
JI Molecules
PD DEC
PY 2022
VL 27
IS 24
AR 9043
DI 10.3390/molecules27249043
PG 21
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 7H0PU
UT WOS:000902914800001
PM 36558176
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Vergès, B
AF Verges, Bruno
TI Cardiovascular disease in type 1 diabetes: A review of epidemiological
   data and underlying mechanisms
SO DIABETES & METABOLISM
LA English
DT Review
DE Cardiovascular disease; Hyperglycaemia; Lipid; Type 1 diabetes;
   Atherosclerosis
ID ALL-CAUSE MORTALITY; CORONARY-ARTERY CALCIFICATION; PROTEIN-KINASE-C;
   CHOLESTERYL ESTER TRANSFER; OXIDATIVE STRESS; GLYCEMIC VARIABILITY;
   ADVANCED GLYCATION; METABOLIC SYNDROME; EXCESS MORTALITY; COMPLICATIONS
   TRIAL/EPIDEMIOLOGY
AB Cardiovascular disease (CVD) is highly prevalent in patients with type 1 diabetes (T1D) and a major cause of mortality. CVD arises earlier in life in T1D patients and is responsible for a significant reduction of at least 11 years' life expectancy. Also, the incidence of CVD is much more pronounced in patients with T1D onset at an earlier age. However, the factors responsible for increased atherosclerosis and CVD in T1D are not yet totally clarified. In addition to the usual cardiovascular (CV) risk factors, chronic hyperglycaemia plays an important role by promoting oxidative stress, vascular inflammation, monocyte adhesion, arterial wall thickening and endothelial dysfunction. Diabetic nephropathy and cardiac autonomic neuropathy are also associated with increased CVD in T1D. In fact, the CVD risk remains significantly increased even in well-controlled T1D patients who have no additional CV risk factors, indicating that other potential factors are likely to be involved. Hypoglycemia and glucose variability could enhance CV disease by promoting oxidative stress, vascular inflammation and endothelial dysfunction. Furthermore, even well-controlled T1D patients show significant qualitative and functional abnormalities of lipoproteins that are likely to be implicated in the development of atherosclerosis and premature CVD. In addition, recent data suggest that a dysfunctional immune system, which is typical of autoimmune T1D, might also promote CVD possibly through inflammatory pathways. Moreover, overweight and obese T1D patients can manifest additional CV risk through pathophysiological mechanisms resembling those observed in type 2 diabetes (T2D). (C) 2020 Elsevier Masson SAS. All rights reserved.
C1 [Verges, Bruno] Univ Hosp, Endocrinol Diabetol Dept, F-21000 Dijon, France.
   [Verges, Bruno] INSERM LNC UMR1231, F-21000 Dijon, France.
C3 Universite Bourgogne Europe; CHU Dijon Bourgogne; Universite Bourgogne
   Europe; Institut National de la Sante et de la Recherche Medicale
   (Inserm); Institut Agro; AgroSup Dijon
RP Vergès, B (corresponding author), Univ Hosp, Endocrinol Diabetol Dept, F-21000 Dijon, France.; Vergès, B (corresponding author), INSERM LNC UMR1231, F-21000 Dijon, France.
EM bruno.verges@chu-dijon.fr
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NR 98
TC 70
Z9 72
U1 1
U2 12
PU MASSON EDITEUR
PI MOULINEAUX CEDEX 9
PA 21 STREET CAMILLE DESMOULINS, ISSY, 92789 MOULINEAUX CEDEX 9, FRANCE
SN 1262-3636
EI 1878-1780
J9 DIABETES METAB
JI Diabetes Metab.
PD NOV
PY 2020
VL 46
IS 6
BP 442
EP 449
DI 10.1016/j.diabet.2020.09.001
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA OW1QJ
UT WOS:000592670200005
PM 32998054
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Koike, A
   Robles, BEF
   Bonacini, AGD
   de Alcantara, CC
   Reiche, EMV
   Dichi, I
   Maes, M
   Cecchini, R
   Simao, ANC
AF Koike, Alexsandro
   Franca Robles, Brunna Emanuella
   da Silva Bonacini, Ana Gabriela
   de Alcantara, Camila Cataldi
   Vissoci Reiche, Edna Maria
   Dichi, Isaias
   Maes, Michael
   Cecchini, Rubens
   Colado Simao, Andrea Name
TI Thiol Groups as a Biomarker for the Diagnosis and Prognosis of Prostate
   Cancer
SO SCIENTIFIC REPORTS
LA English
DT Article
ID OXIDATIVE STRESS; ANTIOXIDANT STATUS; METABOLIC SYNDROME; BENIGN;
   PROTEIN; INFLAMMATION; HYPERPLASIA; REDOX; PROGRESSION; METAANALYSIS
AB Oxidative stress (OS) is associated with the onset of prostate cancer (PCa). The aims of this study are to examine whether OS biomarkers may be employed as external validating criteria for the diagnosis PCa. This case-control study recruited 204 subjects, 73 patients with PCa, 67 patients with benign prostate hyperplasia (BPH), and 64 healthy controls (HC) and assayed plasma prostate-specific antigen (PSA), protein thiol (-SH) groups, lipid hydroperoxides, carbonyl proteins (PCB), advanced oxidation protein products (AOPP), and total radical-trapping antioxidant parameter (TRAP). -SH groups were significantly and inversely associated with PSA levels. PCa was characterized by lowered -SH groups and red blood cell TRAP levels, and higher PSA, AOPP and PCB levels as compared with BPH and HC. Support vector machine with 10-fold cross-validation showed that PSA values together with -SH groups, PCB and AOPP yielded a cross-validation accuracy of 96.34% for the differentiation of PCa from BPH and HC. The area under the ROC curve using PSA and -SH differentiating PCa from BPH and controls was 0.945. Moreover, lowered -SH, but not PSA, are associated with PCa metastasis and progression. Inflammatory biomarkers were not associated with PCa or BPH. PCa, its progression and metastatic PCa are characterized by lowered antioxidant defenses, especially lowered thiol groups, and increased oxidative stress toxicity, suggesting that these processes play a key role in the pathophysiology of PCa. An algorithm based on -SH and PSA values may be used to differentiate patients with PCa from those with BPH and controls.
C1 [Koike, Alexsandro] Univ Londrina, Canc Inst Londrina, Lab Res Appl Immunol, Londrina, Parana, Brazil.
   [Franca Robles, Brunna Emanuella; da Silva Bonacini, Ana Gabriela; de Alcantara, Camila Cataldi] Univ Londrina, Lab Res Appl Immunol, Londrina, Parana, Brazil.
   [Vissoci Reiche, Edna Maria; Colado Simao, Andrea Name] Univ Londrina, Dept Pathol Clin Anal & Toxicol, Lab Res Appl Immunol, Londrina, Parana, Brazil.
   [Dichi, Isaias] Univ Londrina, Dept Internal Med, Londrina, Parana, Brazil.
   [Maes, Michael] Deakin Univ, Sch Med, IMPACT Strateg Res Ctr, Geelong, Vic, Australia.
   [Cecchini, Rubens] Univ Londrina, Dept Pathol Sci, Londrina, Parana, Brazil.
C3 Deakin University
RP Simao, ANC (corresponding author), Univ Londrina, Dept Pathol Clin Anal & Toxicol, Lab Res Appl Immunol, Londrina, Parana, Brazil.
EM deianame@yahoo.com.br
RI Cecchini, Rubens/D-9811-2013; Simão, Andrea/AAM-4892-2021; Maes,
   Michael/B-8546-2011; Alcantara, Camila/P-7423-2016; Reiche, Edna Maria
   Vissoci/C-4102-2013
OI Alcantara, Camila/0000-0002-9181-3925; Reiche, Edna Maria
   Vissoci/0000-0001-6507-2839; Reis, AlessanRSS/0000-0001-8486-7469
FU Brazilian National Council of Research-CNPq; Araucaria Foundation from
   the state of Parana
FX This study was supported by the Brazilian National Council of
   Research-CNPq and by Araucaria Foundation from the state of Parana. We
   thank the University Hospital of State University of Londrina and HU Tec
   Foundation for technical and administrative supports.
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NR 51
TC 12
Z9 12
U1 0
U2 5
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD JUN 4
PY 2020
VL 10
IS 1
AR 9093
DI 10.1038/s41598-020-65918-w
PG 11
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA LY3VC
UT WOS:000540455400004
PM 32499542
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Aydemir, D
   Sarayloo, E
   Ulusu, NN
AF Aydemir, Duygu
   Sarayloo, Ehsan
   Ulusu, Nuriye Nuray
TI ROSIGLITAZONE-INDUCED CHANGES IN THE OXIDATIVE STRESS METABOLISM AND
   FATTY ACID COMPOSITION IN RELATION WITH TRACE ELEMENT STATUS IN THE
   PRIMARY ADIPOCYTES
SO JOURNAL OF MEDICAL BIOCHEMISTRY
LA English
DT Article
DE rosiglitazone; oxidative stress; trace elements; minerals; fatty acid
ID BROWN ADIPOSE-TISSUE; INSULIN-RESISTANCE; SKELETAL-MUSCLE; OBESITY;
   GLUCOSE-6-PHOSPHATE-DEHYDROGENASE; STIMULATION; LIPOLYSIS; ENZYMES; RATS
AB Background: Metabolic syndrome, obesity and type 2 diabetes are metabolic disorders characterized by the insulin resistance and the impairment in the insulin secretion. Since impairment in the oxidative stress and adipocyte metabolism contribute to the formation of obesity and diabetes, targeting adipose tissue can be considered as an effective approach to fight against them. Rosiglitazone is used for treatment for patients with type 2 diabetes via inducing lipogenesis and transdifferentiation of white adipose tissue into brown adipose tissue. Since the development of such therapeutics is required to control the formation and function of brown fat cells, we aimed to reveal possible molecular mechanisms behind rosiglitazone induced biochemical changes in the adipose tissue.
   Methods: Cells were expanded in the adipocyte culture medium supplemented with 5 mu g/mL insulin following 2 days' induction. After those cells were treated with rosiglitazone 0, 0.1 3 mol/L and 10 mu mol/L rosiglitazone for 48 hours and at 8th day, cells were collected and stored at -80 degrees C. Then the cells were used to evaluate antioxidant enzyme activities, mineral and trace element levels and fatty acid composition.
   Results: Glucose-6-phosphate dehydrogenase and glutathione reductase significantly reduced in rosiglitazone-treated groups compared to the control. Na, Mg, K, Ca, Cr, Fe, Ni, Cu, Zn, Rb, Sr, Cs, Ba and Pb were determined in the cell lysates via ICP-MS. Also, relative FAME content decreased in the rosiglitazone-treated groups compared to the control.
   Conclusions: Rosiglitazone treatment at low doses showed promising results which may promote brown adipose tissue formation.
C1 [Aydemir, Duygu; Sarayloo, Ehsan; Ulusu, Nuriye Nuray] Koc Univ, Sch Med, TR-34450 Istanbul, Turkey.
   [Aydemir, Duygu; Sarayloo, Ehsan; Ulusu, Nuriye Nuray] Koc Univ, Res Ctr Translat Med KUTTAM, Istanbul, Turkey.
C3 Koc University; Koc University
RP Ulusu, NN (corresponding author), Koc Univ, Sch Med, TR-34450 Istanbul, Turkey.
EM nulusu@ku.edu.tr
RI Sarayloo, Ehsan/L-6202-2018; Aydemir, Duygu/AAT-8537-2021
OI Ulusu, Nuray Nuriye/0000-0002-3173-1389; Sarayloo,
   Ehsan/0000-0001-5572-2930; Aydemir, Duygu/0000-0002-6449-2708
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NR 43
TC 17
Z9 18
U1 0
U2 6
PU SOC MEDICAL BIOCHEMISTS SERBIA
PI BELGRADE
PA VOJISLAVA ILICA 94B, I SPRAT, STAN 7, BELGRADE, VOZDOVAC, SERBIA
SN 1452-8258
EI 1452-8266
J9 J MED BIOCHEM
JI J. Med. Biochem.
PY 2020
VL 39
IS 3
BP 267
EP 275
DI 10.2478/jomb-2019-0041
PG 9
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA MD2HT
UT WOS:000543795100001
PM 33746608
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Mohamed, R
   Jayakumar, C
   Chen, F
   Fulton, D
   Stepp, D
   Gansevoort, RT
   Ramesh, G
AF Mohamed, Riyaz
   Jayakumar, Calpurnia
   Chen, Feng
   Fulton, David
   Stepp, David
   Gansevoort, Ron T.
   Ramesh, Ganesan
TI Low-Dose IL-17 Therapy Prevents and Reverses Diabetic Nephropathy,
   Metabolic Syndrome, and Associated Organ Fibrosis
SO JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
LA English
DT Article
ID II-INDUCED HYPERTENSION; ACUTE KIDNEY INJURY; INTERSTITIAL FIBROSIS;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; INFLAMMATION; MICE; NETRIN-1;
   DISEASE; INTERLEUKIN-17
AB Diabetes is the leading cause of kidney failure, accounting for >45% of new cases of dialysis. Diabetic nephropathy is characterized by inflammation, fibrosis, and oxidant stress, pathologic features that are shared by many other chronic inflammatory diseases. The cytokine IL-17A was initially implicated as a mediator of chronic inflammatory diseases, but recent studies dispute these findings and suggest that IL-17A can favorably modulate inflammation. Here, we examined the role of IL-17A in diabetic nephropathy. We observed that IL-17A levels in plasma and urine were reduced in patients with advanced diabetic nephropathy. Type 1 diabetic mice that are genetically deficient in IL-17A developed more severe nephropathy, whereas administration of low-dose IL-17A prevented diabetic nephropathy in models of type 1 and type 2 diabetes. Moreover, IL-17A administration effectively treated, prevented, and reversed established nephropathy in genetic models of diabetes. Protective effects were also observed after administration of IL-17F but not IL-17C or IL-17E. Notably, tubular epithelial cell-specific overexpression of IL-17A was sufficient to suppress diabetic nephropathy. Mechanistically, IL-17A administration suppressed phosphorylation of signal transducer and activator of transcription 3, a central mediator of fibrosis, upregulated anti-inflammatory microglia/macrophage WAP domain protein in an AMP-activated protein kinase-dependent manner and favorably modulated renal oxidative stress and AMP-activated protein kinase activation. Administration of recombinant microglia/macrophage WAP domain protein suppressed diabetes-induced albuminuria and enhanced M2 marker expression. These observations suggest that the beneficial effects of IL-17 are isoform-specific and identify low-dose IL-17A administration as a promising therapeutic approach in diabetic kidney disease.
C1 [Mohamed, Riyaz; Jayakumar, Calpurnia; Chen, Feng; Fulton, David; Stepp, David; Ramesh, Ganesan] Georgia Regents Univ, Dept Med, CB-3702,1459 Laney Walker Blvd, Augusta, GA USA.
   [Mohamed, Riyaz; Jayakumar, Calpurnia; Chen, Feng; Fulton, David; Stepp, David; Ramesh, Ganesan] Georgia Regents Univ, Vasc Biol Ctr, CB-3702,1459 Laney Walker Blvd, Augusta, GA USA.
   [Gansevoort, Ron T.] Univ Groningen, Univ Med Ctr Groningen, Dept Nephrol, Groningen, Netherlands.
C3 University System of Georgia; Augusta University; University System of
   Georgia; Augusta University; University of Groningen
RP Ramesh, G (corresponding author), Georgia Regents Univ, Dept Med, CB-3702,1459 Laney Walker Blvd, Augusta, GA USA.; Ramesh, G (corresponding author), Georgia Regents Univ, Vasc Biol Ctr, CB-3702,1459 Laney Walker Blvd, Augusta, GA USA.
EM gramesh@gru.edu
RI Ganesan, Ramesh/KEI-8346-2024; Chen, Feng/E-1133-2011
OI Mohamed, Riyaz/0000-0003-2398-3057; Chen, Feng/0000-0003-3508-8834
FU National Institute of Diabetes and Digestive and Kidney Diseases,
   National Institutes of Health [1R01-DK08337901A5]; American Heart
   Association
FX G.R. is supported by an R01 grant from the National Institute of
   Diabetes and Digestive and Kidney Diseases, National Institutes of
   Health (1R01-DK08337901A5). R.M. is supported by a postdoctoral
   fellowship from the American Heart Association.
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NR 49
TC 97
Z9 105
U1 1
U2 14
PU AMER SOC NEPHROLOGY
PI WASHINGTON
PA 1725 I ST, NW STE 510, WASHINGTON, DC 20006 USA
SN 1046-6673
EI 1533-3450
J9 J AM SOC NEPHROL
JI J. Am. Soc. Nephrol.
PD MAR
PY 2016
VL 27
IS 3
BP 745
EP 765
DI 10.1681/ASN.2014111136
PG 21
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA DF1LN
UT WOS:000371101400013
PM 26334030
OA Green Published
DA 2025-06-11
ER

PT J
AU Habbout, A
   Delemasure, S
   Goirand, F
   Guilland, JC
   Chabod, F
   Sediki, M
   Rochette, L
   Vergely, C
AF Habbout, Ahmed
   Delemasure, Stephanie
   Goirand, Francoise
   Guilland, Jean-Claude
   Chabod, Franck
   Sediki, Mourad
   Rochette, Luc
   Vergely, Catherine
TI Postnatal overfeeding in rats leads to moderate overweight and to
   cardiometabolic and oxidative alterations in adulthood
SO BIOCHIMIE
LA English
DT Article
DE Postnatal overfeeding; Oxidative stress; Heart; Ischemia; Rats
ID ACUTE MYOCARDIAL-INFARCTION; METABOLIC SYNDROME; ADIPOSE-TISSUE;
   VITAMIN-C; GLUCOCORTICOID METABOLISM; LEPTIN RECEPTOR; NEUROPEPTIDE-Y;
   OBESITY; STRESS; INSULIN
AB In contrast to the masses of data on obesity, few data are available concerning the cardiometabolic and oxidative consequences of moderate overweight. The model of postnatal overfeeding (OF) induces an increase in body weight at weaning that remains during adult life.
   Litters of Wistar rats were either maintained at 12 pups (normal-fed group, NF), or reduced to 3 pups at birth in order to induce OF. At 6 months of age, metabolic parameters, circulating oxidative stress and aortic and coronary vasoreactivity were assessed. Cardiac susceptibility to ischemia-reperfusion injury was also evaluated ex vivo as were markers of cardiac remodeling. OF led to an increase in body weight at weaning (+50%); the increase in body weight persisted throughout adult life, but was less marked (+10%). Significant increases in plasma levels of fasting glucose, insulin and leptin were found in OF rats. An increase in both plasma hydroperoxides and cardiac superoxide dismutase activity and a decrease in plasma ascorbate were found in OF rats. Vasoreactivity was not modified, but ex vivo, after 30 min of ischemia, isolated hearts from OF rats showed lower recovery of coronary flow along with a greater release of LDH. Studies on heart tissues showed an increase in collagen content and increased expression and activity of MMP-2.
   Our findings show that moderate overweight in adult rats, induced by postnatal overfeeding, leads to both metabolic and oxidative disturbances as well as a higher susceptibility to cardiac injury after ischemia ex vivo, which may be explained, at least in part, by ventricular remodeling. (C) 2011 Elsevier Masson SAS. All rights reserved.
C1 [Habbout, Ahmed; Delemasure, Stephanie; Goirand, Francoise; Guilland, Jean-Claude; Chabod, Franck; Sediki, Mourad; Rochette, Luc; Vergely, Catherine] Univ Bourgogne, Lab Physiopathol & Pharmacol Cardiovasc Expt EA29, Fac Med & Pharm, IFR SANTE STIC, F-21000 Dijon, France.
C3 Universite Bourgogne Europe
RP Vergely, C (corresponding author), Univ Bourgogne, Lab Physiopathol & Pharmacol Cardiovasc Expt EA29, Fac Med & Pharm, IFR SANTE STIC, 7 Blvd Jeanne Arc, F-21000 Dijon, France.
EM cvergely@u-bourgogne.fr
RI ; VERGELY, CATHERINE/L-9534-2015
OI Rochette, Luc/0000-0001-9973-8803; VERGELY,
   CATHERINE/0000-0003-4009-776X
FU French Ministry of Research; Regional Council of Burgundy
FX This work was supported by grants from the French Ministry of Research
   and from the Regional Council of Burgundy.
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NR 41
TC 43
Z9 47
U1 0
U2 4
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI PARIS
PA 23 RUE LINOIS, 75724 PARIS, FRANCE
SN 0300-9084
J9 BIOCHIMIE
JI Biochimie
PD JAN
PY 2012
VL 94
IS 1
BP 117
EP 124
DI 10.1016/j.biochi.2011.09.023
PG 8
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 895CG
UT WOS:000300473200014
PM 21978927
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Koh, EH
   Kim, M
   Ranjan, KC
   Kim, HS
   Park, HS
   Oh, KS
   Park, IS
   Lee, WJ
   Kim, MS
   Park, JY
   Youn, JH
   Lee, KU
AF Koh, Eun Hee
   Kim, Mina
   Ranjan, K. C.
   Kim, Hyun Sik
   Park, Hye-Sun
   Oh, Ki Sook
   Park, In-Sun
   Lee, Woo Je
   Kim, Min-Seon
   Park, Joong-Yeol
   Youn, Jang Hyun
   Lee, Ki-Up
TI eNOS plays a major role in adiponectin synthesis in adipocytes
SO AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
LA English
DT Article
DE endothelial nitric oxide synthase; mitochondrial biogenesis; oxidative
   stress; nitric oxide
ID NITRIC-OXIDE SYNTHASE; MITOCHONDRIAL BIOGENESIS; INSULIN-RESISTANCE;
   OXIDATIVE STRESS; METABOLIC SYNDROME; SKELETAL-MUSCLE; GLUT4
   TRANSLOCATION; MICE LACKING; CELLS; ROSIGLITAZONE
AB Koh EH, Kim M, Ranjan KC, Kim HS, Park HS, Oh KS, Park IS, Lee WJ, Kim MS, Park JY, Youn JH, Lee KU. eNOS plays a major role in adiponectin synthesis in adipocytes. Am J Physiol Endocrinol Metab 298: E846-E853, 2010. First published February 2, 2010; doi:10.1152/ajpendo.00008.2010-Nitric oxide (NO) stimulates mitochondrial biogenesis. We recently reported that adiponectin synthesis is regulated by mitochondrial function in adipocytes. This study was undertaken to test the hypothesis that endothelial NO synthase (eNOS) plays an important role in adiponectin synthesis by producing NO and enhancing mitochondrial function in adipocytes. We examined the effects of eNOS knockdown on adiponectin synthesis in 3T3-L1 adipocytes and also examined plasma adiponectin levels and the mitochondria in adipose tissue of eNOS knockout (eNOS(-/-)) mice with and without chronic administration of a NO donor. In cultured 3T3-L1 adipocytes, eNOS siRNA decreased rosiglitazone-induced adiponectin secretion, which was associated with decreases in mitochondrial proteins and biogenesis factors. Plasma adiponectin concentrations were reduced in adult eNOS(-/-) mice compared with age-matched wild-type mice. Mitochondrial contents in adipose tissue were reduced in eNOS(-/-) mice, and this was associated with decreased expression of mitochondrial biogenesis factors, increased levels of 8-hydroxyguanosine, a biomarker of oxidative stress, and morphological abnormalities in mitochondria. Rosiglitazone-induced increases in adiponectin expression and mitochondrial content were also reduced significantly in eNOS(-/-) mice. Chronic administration of a NO donor reversed mitochondrial abnormalities and increased adiponectin expression in adipose tissue of eNOS(-/-) mice. eNOS plays an important role in adiponectin synthesis in adipocytes by increasing mitochondrial biogenesis and enhancing mitochondrial function.
C1 [Koh, Eun Hee; Lee, Woo Je; Kim, Min-Seon; Park, Joong-Yeol; Lee, Ki-Up] Univ Ulsan, Coll Med, Dept Internal Med, Seoul 138736, South Korea.
   [Kim, Mina; Kim, Hyun Sik; Park, Hye-Sun] Asan Inst Life Sci, Seoul, South Korea.
   [Ranjan, K. C.; Park, In-Sun] Inha Univ, Coll Med, Dept Anat, Inchon, South Korea.
   [Oh, Ki Sook; Youn, Jang Hyun] Univ So Calif, Sch Med, Dept Physiol & Biophys, Los Angeles, CA 90033 USA.
C3 University of Ulsan; Inha University; University of Southern California
RP Lee, KU (corresponding author), Univ Ulsan, Coll Med, Dept Internal Med, Seoul 138736, South Korea.
EM kulee@amc.seoul.kr
RI Park, Jun/HPH-3570-2023; LEE, WOO/E-3689-2010
FU Korean government (Ministry of Education, Science, and Technology)
   [20062005412, 2009-0091988, M1040000000804J000000810]; Korean Diabetes
   Association; Asan Institute for Life Sciences, Seoul, Republic of Korea
FX This work was supported by a National Research Foundation grant funded
   by the Korean government (Ministry of Education, Science, and
   Technology) (20062005412, 2009-0091988 to K.U. Lee and NRL
   M1040000000804J000000810 to J.Y. Park), a grant from the Korean Diabetes
   Association (E.H. Koh, 2006), and a grant (2008-006) from Asan Institute
   for Life Sciences, Seoul, Republic of Korea.
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NR 47
TC 38
Z9 43
U1 0
U2 4
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0193-1849
EI 1522-1555
J9 AM J PHYSIOL-ENDOC M
JI Am. J. Physiol.-Endocrinol. Metab.
PD APR
PY 2010
VL 298
IS 4
BP E846
EP E853
DI 10.1152/ajpendo.00008.2010
PG 8
WC Endocrinology & Metabolism; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Physiology
GA 571PY
UT WOS:000275768100014
PM 20124507
DA 2025-06-11
ER

PT J
AU Rafikova, O
   Salah, EM
   Tofovic, SP
AF Rafikova, Olga
   Salah, Eman M.
   Tofovic, Stevan P.
TI Renal and metabolic effects of tempol in obese ZSF1
   rats-distinct role for superoxide and hydrogen peroxide in diabetic
   renal injury
SO METABOLISM-CLINICAL AND EXPERIMENTAL
LA English
DT Article
ID IMPROVES INSULIN SENSITIVITY; OXIDATIVE STRESS; GLOMERULAR INJURY;
   ANTIOXIDANT ENZYMES; RADICAL SCAVENGER; OXYGEN RADICALS; NITRIC-OXIDE;
   DISMUTASE; HYPERTENSION; DYSFUNCTION
AB Oxidative stress, that is, overproduction of reactive oxygen species and reduced antioxidant system activity, is implicated in the pathogenesis of diabetic complications; and therefore, Superoxide dismutase (SOD) mimetic tempol should be protective in diabetic kidney. However, the effects of tempol in metabolic syndrome-associated renal injury have not been thoroughly examined. In this study, we examined the effects of 9 weeks of treatment with tempol on metabolic status, renal oxidative stress, and kidney function and structure in obese, diabetic, hypertensive ZSF(1) rats and their nondiabetic, hypertensive, lean littermates. The obese rats had significantly reduced total SOD and catalase activity, increased peroxidase activity and lipid peroxidation, and higher level of protein oxidation in renal cortical tissue compared with their lean littermates. These changes were accompanied by renal injury (proteinuria; reduced excretory function; and markedly increased glomerular and interstitial inflammation, proliferation, and collagen IV synthesis). Tempol treatment slightly increased total SOD activity. significantly reduced lipid peroxidation and peroxidase activity, but had no effect on catalase and protein oxidation. Tempol had no effects on blood pressure, renal hemodynamics and excretory function, and proteinuria in obese rats, yet improved insulin sensitivity and reduced renal inflammatory, proliferative, and fibrotic changes. Because tempol possesses no catalase activity and, in diabetes, not only SOD but also catalase is inhibited, it is possible that the toxicity of hydrogen peroxide (H2O2) remains unaltered under tempol treatment. This Study Suggests that superoxide and H2O2 may have distinct roles in the pathogenesis of diabetic renal injury, with superoxide mainly being involved in inflammatory, proliferative, and fibrotic changes, and H2O2 in glomerular hemodynamics and proteinuria. (C) 2008 Elsevier Inc. All rights reserved.
C1 [Tofovic, Stevan P.] Univ Pittsburgh, Sch Med, Dept Med, Ctr Clin Pharmacol, Pittsburgh, PA 15219 USA.
   [Salah, Eman M.] Univ Pittsburgh, Sch Med, Dept Pathol, Pittsburgh, PA 15219 USA.
   [Salah, Eman M.] VA Pittsburgh Hlth Syst, Pittsburgh, PA 15240 USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE); University
   of Pittsburgh; Pennsylvania Commonwealth System of Higher Education
   (PCSHE); University of Pittsburgh; US Department of Veterans Affairs;
   Veterans Health Administration (VHA); VA Pittsburgh Healthcare System
RP Tofovic, SP (corresponding author), Univ Pittsburgh, Sch Med, Dept Med, Ctr Clin Pharmacol, Pittsburgh, PA 15219 USA.
EM tofovic@dom.pitt.edu
RI Muhammad Salah El Deen Muhammad, Eman/D-7423-2019
OI Muhammad Salah El Deen Muhammad, Eman/0000-0002-0954-6531
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NR 51
TC 37
Z9 44
U1 0
U2 0
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0026-0495
EI 1532-8600
J9 METABOLISM
JI Metab.-Clin. Exp.
PD OCT
PY 2008
VL 57
IS 10
BP 1434
EP 1444
DI 10.1016/j.metabol.2008.05.014
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 363BI
UT WOS:000260240500019
PM 18803950
DA 2025-06-11
ER

PT J
AU Singh, SSB
   Patil, KN
AF Singh, Sangeetha S. B.
   Patil, K. Neelakanteshwar
TI SIRT1/AMPK-mediated pathway: Ferulic acid from sugar beet pulp
   mitigating obesity-induced diabetes-linked complications and improving
   metabolic health
SO BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
LA English
DT Article
DE Sugar beet pulp; Ferulic acid; High -fat diet; SIRT1/AMPK pathway; AGEs;
   Hepatic steatosis
ID ACTIVATED PROTEIN-KINASE; GLYCATION END-PRODUCTS; DIET-INDUCED OBESITY;
   OXIDATIVE STRESS; LIPID-ACCUMULATION; ALKALINE-HYDROLYSIS;
   INSULIN-RESISTANCE; AMPK; EXTRACTION; METFORMIN
AB Obesity-induced type 2 diabetes (T2D) increases the risk of metabolic syndrome due to the high calorie intake. The role of sugar beet pulp (SBP) in T2D and the mechanism of its action remain unclear, though it is abundant in phenolics and has antioxidant activity. In this study, we isolated and purified ferulic acid from SBP, referred to as SBP-E, and studied the underlying molecular mechanisms in the regulation of glucose and lipid metabolism developing high glucose/high fat diet-induced diabetic models in vitro and in vivo. SBP-E showed no cytotoxicity and reduced the oxidative stress by increasing glutathione (GSH) in human liver (HepG2) and rat skeletal muscle (L6) cells. It also decreased body weight gain, food intake, fasting blood glucose levels (FBGL), glucose intolerance, hepatic steatosis, and lipid accumulation. Additionally, SBP-E decreased the oxidative stress and improved the antioxidant enzyme levels in high-fat diet (HFD)-induced T2D mice. Further, SBP-E reduced plasma and liver advanced glycation end products (AGEs), malondialdehyde (MDA), and pro-inflammatory cytokines, and increased anti-inflammatory cytokines in HFD-fed mice. Importantly, SBP-E significantly elevated AMPK, glucose transporter, SIRT1 activity, and Nrf2 expression and decreased ACC activity and SREBP1 levels in diabetic models. Collectively, our study results suggest that SBP-E treatment can improve obesity-induced T2D by regulating glucose and lipid metabolism via SIRT1/AMPK signalling and the AMPK/SREBP1/ACC1 pathway.
C1 [Singh, Sangeetha S. B.; Patil, K. Neelakanteshwar] CSIR, Cent Food Technol Res Inst, Dept Microbiol & Fermentat Technol, Mysuru 570020, Karnataka, India.
   Acad Sci & Innovat Res AcSIR, Ghaziabad 201002, Uttar Pradesh, India.
C3 Council of Scientific & Industrial Research (CSIR) - India; CSIR -
   Central Food Technological Research Institute (CFTRI); Academy of
   Scientific & Innovative Research (AcSIR)
RP Patil, KN (corresponding author), CSIR, Cent Food Technol Res Inst, Dept Microbiol & Fermentat Technol, Mysuru 570020, Karnataka, India.
EM knpatil@cftri.res.in
OI Patil, K. Neelakanteshwar/0000-0002-9402-1341
FU CSIR-12th five year plan project [BSC-0404, MLP-0286]; DST-INSPIRE
   [IF-160464]
FX The research was partially funded by the CSIR-12th five year plan
   project, BSC-0404, and MLP-0286 to K.N.P. Sangeetha S. B. Singh is
   recipient of DST-INSPIRE (File No: IF-160464) in 2016.
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NR 85
TC 7
Z9 7
U1 1
U2 6
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1388-1981
EI 1879-2618
J9 BBA-MOL CELL BIOL L
JI Biochim. Biophys. Acta Mol. Cell Biol. Lipids
PD OCT
PY 2024
VL 1869
IS 7
AR 159511
DI 10.1016/j.bbalip.2024.159511
EA JUN 2024
PG 16
WC Biochemistry & Molecular Biology; Biophysics; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Cell Biology
GA XH6A3
UT WOS:001260818600001
PM 38761896
DA 2025-06-11
ER

PT J
AU Wang, P
   Gao, JP
   Ke, WX
   Wang, J
   Li, DT
   Liu, RL
   Jia, Y
   Wang, XH
   Chen, X
   Chen, F
   Hu, XS
AF Wang, Pan
   Gao, Jianpeng
   Ke, Weixin
   Wang, Jing
   Li, Daotong
   Liu, Ruolin
   Jia, Yan
   Wang, Xuehua
   Chen, Xin
   Chen, Fang
   Hu, Xiaosong
TI Resveratrol reduces obesity in high-fat diet-fed mice via modulating the
   composition and metabolic function of the gut microbiota
SO FREE RADICAL BIOLOGY AND MEDICINE
LA English
DT Article
DE Obesity; Resveratrol; Oxidative stress; Gut microbiota; Metabolism;
   Fecal transplant
ID OXIDATIVE STRESS; INTESTINAL INFLAMMATION; MOUSE MODEL; DYSFUNCTION;
   QUERCETIN; ASSOCIATION; POLYPHENOLS; DISEASES; CAPACITY; PROTECTS
AB Resveratrol (RSV) is a natural polyphenol with anti-obesity effects. However, the mechanisms of anti-obesity remain unclear due to its low bioavailability. Recent evidence demonstrates that gut microbiota plays a key role in obesity. This spurred us to investigate whether the anti-obesity effects of RSV are related to modulations in the gut microbiota and metabolic functions. Here, RSV significantly improved metabolic phenotype and intestinal oxidative stress in the high-fat diet (HFD)-fed mice. A multi-omics approach was used to systematically profile the microbial signatures at both the phylogenetic and functional levels using 16S rRNA gene sequencing and metagenome. At the phylogenetic level, RSV treatment significantly modulated the gut microbiota composition in HFD-fed mice, characterized with increased Blautia abundance and decreased Desulfovibrio and Lachnospiraceae_NK4A136_group abundance. At the functional level, RSV significantly decreased the enrichment of pathways linked to host metabolic disease and increased the enrichment of pathways involved in the generation of small metabolites. Besides, the fecal microbiota transplantation experiment showed anti-obesity and microbiota-modulating effects similar to those observed in the oral RSV-feeding experiment. Furthermore, metabolomic analysis and antibiotic treatment verified that 4-hydroxyphenylacetic acid (4-HPA) and 3-hydroxyphenylpropionic acid (3-HPP) were the two gut metabolites of RSV, which contribute to improving lipid metabolism in vitro. Moreover, the content of 4-HPA and 3-HPP exhibited strong correlation with the intestinal oxidative state. We concluded that the RSV-mediated alteration of gut microbiota, related gut metabolites and redox state of the intestinal environment contributed to prevention of metabolic syndrome in HFD-fed mice.
C1 [Wang, Pan; Ke, Weixin; Li, Daotong; Wang, Xuehua; Chen, Fang; Hu, Xiaosong] Minist Agr, Key Lab Fruits & Vegetables Proc, Natl Engn Res Ctr Fruit & Vegetable Proc, Coll Food Sci & Nutr Engn, Beijing 100083, Peoples R China.
   [Wang, Pan; Ke, Weixin; Li, Daotong; Wang, Xuehua; Chen, Fang; Hu, Xiaosong] China Agr Univ, Minist Educ, Engn Res Ctr Fruits & Vegetables Proc, Beijing 100083, Peoples R China.
   [Gao, Jianpeng; Liu, Ruolin; Jia, Yan] Novogene Bioinformat Inst, Beijing 100000, Peoples R China.
   [Wang, Jing] Zhejiang Univ, Ningbo Res Inst, Ningbo 315100, Peoples R China.
   [Chen, Xin] Univ Calif San Francisco, Dept Bioengn & Therapeut Sci, San Francisco, CA 94143 USA.
   [Chen, Xin] Univ Calif San Francisco, Liver Ctr, San Francisco, CA 94143 USA.
C3 Ministry of Agriculture & Rural Affairs; Ministry of Education - China;
   China Agricultural University; Zhejiang University; University of
   California System; University of California San Francisco; University of
   California System; University of California San Francisco
RP Hu, XS (corresponding author), China Agr Univ, Coll Food Sci & Nutr Engn, 17 Qinghua East Rd, Beijing 100083, Peoples R China.
EM huxiaos@263.net
RI yang, xiaodan/KTI-6719-2024; Li, Daotong/AAB-6489-2020; Liu,
   Ruolin/MVT-5047-2025; Co, Annie/LBI-5115-2024; Wang, Jing/ABB-5658-2021
OI Wang, Pan/0000-0003-3301-3177; Wang, Jing/0000-0002-6394-5357; Hu,
   Xiao/0000-0003-1128-4099
FU National Key Technologies RD Program [2017YFD0400700]; National Natural
   Science Foundation of China [31530058]
FX This work was supported by the grant from National Key Technologies R&D
   Program [grant number 2018YFC1602202], National Natural Science
   Foundation of China [grant number 31530058] and National Key
   Technologies R&D Program [grant number 2017YFD0400700].
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NR 72
TC 172
Z9 189
U1 6
U2 192
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0891-5849
EI 1873-4596
J9 FREE RADICAL BIO MED
JI Free Radic. Biol. Med.
PD AUG 20
PY 2020
VL 156
BP 83
EP 98
DI 10.1016/j.freeradbiomed.2020.04.013
PG 16
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA NA9KN
UT WOS:000560135700003
PM 32305646
DA 2025-06-11
ER

PT J
AU Al Mamun, MA
   Faruk, M
   Rahman, MM
   Nahar, K
   Kabir, F
   Alam, MA
   Subhan, N
AF Al Mamun, Md. Abdullah
   Faruk, Md.
   Rahman, Md. Mizanur
   Nahar, Kamrun
   Kabir, Fariha
   Alam, Md Ashraful
   Subhan, Nusrat
TI High Carbohydrate High Fat Diet Induced Hepatic Steatosis and
   Dyslipidemia Were Ameliorated by Psidium guajava Leaf Powder
   Supplementation in Rats
SO EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Article
ID INSULIN-RESISTANCE; METABOLIC SYNDROME; OXIDATIVE STRESS;
   LIPID-METABOLISM; OBESITY; MECHANISMS; MUSCLE; EPIDEMIOLOGY;
   PATHOGENESIS; INFLAMMATION
AB Psidium guajava leaf is reported to contain many bioactive polyphenols which play an important role in the prevention and treatment of various diseases. Our investigation aimed to study the effect of Psidium guajava leaf powder supplementation on obesity and liver status by using experimental rats. To study the effects of guava leaf supplementation in high fat diet induced obesity, rats were randomly divided into four experimental groups (n=7), control (group I), control + guava leaf (group II), HCHF (group III), and HCHF + guava leaf (group IV). At the end of the experimental period (56 days), glucose intolerance, liver enzymes activities, antioxidant enzymes activities, and lipid and cholesterol profiles were evaluated. Our results revealed that guava leaf powder supplementation showed a significant reduction in fat deposition in obese rats. Moreover, liver enzyme functions were increased in high fat diet fed rats compared to the control rats significantly which were further ameliorated by guava leaf powder supplementation in high fat diet fed rats. High fat diet feeding also decreased the antioxidant enzyme functions and increased the lipid peroxidation products compared to the control rats. Guava leaf powder supplementation in high fat diet fed rats reduced the oxidative stress markers and reestablished antioxidant enzyme system in experimental animals. Guava leaf powder supplementation in high fat diet fed rats also showed a relative decrease in inflammatory cells infiltration and collagen deposition in the liver compared to the high fat diet fed rats. The present study suggests that the supplementation of guava leaf powder prevents obesity, improves glucose intolerance, and decreases inflammation and oxidative stress in liver of high carbohydrate high fat diet fed rats.
C1 [Al Mamun, Md. Abdullah; Faruk, Md.; Rahman, Md. Mizanur; Nahar, Kamrun; Kabir, Fariha; Alam, Md Ashraful; Subhan, Nusrat] North South Univ, Dept Pharmaceut Sci, Dhaka, Bangladesh.
C3 North South University (NSU)
RP Alam, MA; Subhan, N (corresponding author), North South Univ, Dept Pharmaceut Sci, Dhaka, Bangladesh.
EM mamunabdullah808@gmail.com; md.faruk2706@northsouth.edu;
   mizanph09@gmail.com; kamrunmukta12@gmail.com; farihakabir10@gmail.com;
   sonaliagun@yahoo.com; rimmi04@yahoo.com
RI Alam, Ashraful/G-1964-2014; Faruk, Md Tanveer/LIG-4864-2024; Nahar,
   Dr.Kamrun/JFS-9212-2023; Rahman, Md Mizanur/AAC-7666-2019
OI Kabir, Fariha/0000-0001-6412-5257; Rahman, Md
   Mizanur/0000-0002-7178-7977; Alam, Md Ashraful/0000-0001-7596-5868
FU North South University
FX This research received a small research grant from North South
   University awarded to Dr. Md Ashraful Alam in 2017. The research was
   conducted in the Department of Pharmaceutical Sciences, North South
   University, Dhaka, Bangladesh. The authors thankfully avowed all the
   logistic supports provided by the Department of Pharmaceutical Sciences,
   North South University, Bangladesh, and BCSIR Laboratories, Bangladesh
   Council of Scientific and Industrial Research, Dhaka, Bangladesh.
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NR 51
TC 16
Z9 17
U1 0
U2 9
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1741-427X
EI 1741-4288
J9 EVID-BASED COMPL ALT
JI Evid.-based Complement Altern. Med.
PY 2019
VL 2019
AR 1897237
DI 10.1155/2019/1897237
PG 12
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA HL8RA
UT WOS:000459009100001
PM 30854003
OA gold, Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Kundur, AR
   Singh, I
   Bulmer, AC
AF Kundur, Avinash R.
   Singh, Indu
   Bulmer, Andrew C.
TI Bilirubin, platelet activation and heart disease: A missing link to
   cardiovascular protection in Gilbert's syndrome?
SO ATHEROSCLEROSIS
LA English
DT Review
DE Gilbert's syndrome; Unconjugated bilirubin; Antioxidant; Platelets;
   Oxidative stress; Thrombosis; Cardiovascular disease
ID CORONARY-ARTERY-DISEASE; LOW-DENSITY-LIPOPROTEIN; INTIMA-MEDIA
   THICKNESS; SOLUBLE P-SELECTIN; C-REACTIVE PROTEIN; ENDOTHELIAL ADHESION
   MOLECULES; ALBUMIN-BOUND BILIRUBIN; HIGHER SERUM BILIRUBIN; OXIDATIVE
   STRESS; METABOLIC SYNDROME
AB Gilbert's syndrome (GS) is a relatively common condition, inducing a benign, non-hemolytic, unconjugated hyperbilirubinemia. Gilbert's Syndrome is associated with mutation in the Uridine Glucuronosyl Transferase 1A1 (UGT1A1) gene promoter, reducing UGT1A1 activity, which normally conjugates bilirubin allowing its elimination from the blood. Individuals with GS demonstrate mildly elevated plasma antioxidant capacity caused by elevated levels of unconjugated bilirubin (UCB), reduced thiols and glutathione. Interestingly, the development of, and risk of mortality from, cardiovascular disease is remarkably reduced in GS individuals. An explanation for this protection may be explained by bilirubin's ability to inhibit multiple processes that induce platelet hyper-reactivity and thrombosis, thus far underappreciated in the literature. Reactive oxygen species are produced continuously via metabolic processes and have the potential to oxidatively modify proteins and lipids within cell membranes, which may encourage the development of thrombosis and CVDs. Oxidative stress induced platelet hyper-reactivity significantly increases the risk of thrombosis, which can potentially lead to tissue infarction. Here, we discuss the possible mechanisms by which increased antioxidant status might influence platelet function and link this to cardiovascular protection in GS. In summary, this is the first article to discuss the possible role of bilirubin as an anti-thrombotic agent, which inhibits platelet activation and potentially, organ infarction, which could contribute to the reduced mortality rate in mildly hyperbilirbinemic individuals. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
C1 [Kundur, Avinash R.; Singh, Indu; Bulmer, Andrew C.] Griffith Univ, Griffith Hlth Inst, Heart Fdn Res Ctr, Southport, Qld 4222, Australia.
C3 Griffith University; Griffith University - Gold Coast Campus; Menzies
   Health Institute Queensland
RP Bulmer, AC (corresponding author), Griffith Univ, Sch Med Sci, Gold Coast Campus,Parklands Dr, Southport, Qld 4222, Australia.
EM a.bulmer@griffith.edu.au
OI Bulmer, Andrew/0000-0002-2994-7893; Singh, Indu/0000-0002-0498-4209
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NR 150
TC 78
Z9 82
U1 0
U2 19
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0021-9150
EI 1879-1484
J9 ATHEROSCLEROSIS
JI Atherosclerosis
PD MAR
PY 2015
VL 239
IS 1
BP 73
EP 84
DI 10.1016/j.atherosclerosis.2014.12.042
PG 12
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA CB6RH
UT WOS:000349753800012
PM 25576848
DA 2025-06-11
ER

PT J
AU Banihani, S
   Swedan, S
   Alguraan, Z
AF Banihani, Saleem
   Swedan, Sarney
   Alguraan, Ziyad
TI Pomegranate and type 2 diabetes
SO NUTRITION RESEARCH
LA English
DT Article
DE Type 2 diabetes; Pomegranate juice; Pomegranate flowers; Pomegranate
   peels; Pomegranate seeds; Oxidative stress
ID NF-KAPPA-B; PUNICA-GRANATUM L.; OXIDATIVE STRESS; PPAR-GAMMA;
   LIPID-PEROXIDATION; SEED OIL; ANTIOXIDANT ACTIVITY; DIAGNOSTIC-CRITERIA;
   METABOLIC SYNDROME; ENDOTHELIAL-CELLS
AB Over the last decade, various studies have linked pomegranate (Punica granatum Linn), a fruit native to the Middle East, with type 2 diabetes prevention and treatment. This review focuses on current laboratory and clinical research related to the effects of pomegranate fractions (peels, flowers, and seeds) and some of their active components on biochemical and metabolic variables associated with the pathologic markers of type 2 diabetes. This review systematically presents findings from cell culture and animal studies as well as clinical human research. One key mechanism by which pomegranate fractions affect the type 2 diabetic condition is by reducing oxidative stress and lipid peroxidation. This reduction may occur by directly neutralizing the generated reactive oxygen species, increasing certain antioxidant enzyme activities, inducing metal chelation activity, reducing resistin formation, and inhibiting or activating certain transcriptional factors, such as nuclear factor kappa B and peroxisome proliferator-activated receptor gamma. Fasting blood glucose levels were decreased significantly by punicic acid, methanolic seed extract, and pomegranate peel extract. Known compounds in pomegranate, such as punicalagin and ellagic, gallic, oleanolic, ursolic, and uallic acids, have been identified as having antidiabetic actions. Furthermore, the juice sugar fraction was found to have unique antioxidant polyphenols (tannins and anthocyanins), which could be beneficial to control conditions in type 2 diabetes. These findings provide evidence for the anti-diabetic activity of pomegranate fruit; however, before pomegranate or any of its extracts can be medically recommended for the management of type 2 diabetes, controlled, clinical studies, are needed. (C) 2013 Elsevier Inc. All rights reserved.
C1 [Banihani, Saleem; Swedan, Sarney] Jordan Univ Sci & Technol, Dept Med Lab Sci, Irbid 22110, Jordan.
   [Alguraan, Ziyad] Jordanian Royal Med Serv, King Hussein Med Ctr, Amman, Jordan.
C3 Jordan University of Science & Technology
RP Banihani, S (corresponding author), Jordan Univ Sci & Technol, Dept Med Lab Sci, POB 3030, Irbid 22110, Jordan.
EM sabanihani@justedu.jo
RI Alguraan, Ziyad/MAH-8563-2025; swedan, samer/H-4228-2014
OI swedan, samer/0000-0002-2847-9397; Alguraan, Ziyad/0009-0009-2635-875X
FU Jordan University of Science and Technology
FX This study was supported by Jordan University of Science and Technology.
   The authors would like to thank Laila Nimri for her assistance.
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NR 69
TC 160
Z9 171
U1 2
U2 122
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0271-5317
J9 NUTR RES
JI Nutr. Res.
PD MAY
PY 2013
VL 33
IS 5
BP 341
EP 348
DI 10.1016/j.nutres.2013.03.003
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 156XF
UT WOS:000319856500001
PM 23684435
DA 2025-06-11
ER

PT J
AU Kodavanti, UP
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AF Kodavanti, Urmila P.
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   Gilmour, Peter S.
   Pinkerton, Kent E.
TI The spontaneously hypertensive rat: An experimental model of sulfur
   dioxide-induced airways disease
SO TOXICOLOGICAL SCIENCES
LA English
DT Article
DE chronic obstructive pulmonary disease; bronchitis; spontaneously
   hypertensive rats; sulfur dioxide exposure; mucus hypersecretion;
   inflammation
ID OBSTRUCTIVE PULMONARY-DISEASE; CHRONIC-BRONCHITIS; PARTICULATE MATTER;
   METABOLIC SYNDROME; BREATHING PATTERN; OXIDATIVE STRESS; RODENT MODELS;
   C-FIBERS; MICE; COPD
AB Chronic obstructive pulmonary disease (COPD) is characterized by airway obstruction, inflammation, and mucus hypersecretion, features that are common in bronchitis, emphysema, and often asthma. However, current rodent models do not reflect this human disease. Because genetically predisposed spontaneously hypertensive (SH) rats display phenotypes such as systemic inflammation, hypercoagulation, oxidative stress, and suppressed immune function that are also apparent in COPD patients, we hypothesized that SH rat may offer a better model of experimental bronchitis. We, therefore, exposed SH and commonly used Sprague Dawley (SD) rats (male, 13- to 15-weeks old) to 0, 250, or 350 ppm sulfur dioxide (SO2), 5 h/day for 4 consecutive days to induce airway injury. SO2 caused dose-dependent changes in breathing parameters in both strains with SH rats being slightly more affected than SD rats. Increases in bronchoalveolar lavage fluid (BALF) total cells and neutrophilic inflammation were dose dependent and significantly greater in SH than in SD rats. The recovery was incomplete at 4 days following SO2 exposure in SH rats. Pulmonary protein leakage was modest in either strain, but lactate dehydrogenase and N-acetyl glucosaminidase activity were increased in BALF of SH rats. Airway pathology and morphometric evaluation of mucin demonstrated significantly greater impact of SO2 in SH than in SD rats. Baseline differences in lung gene expression pattern suggested marked immune dysregulation, oxidative stress, impairment of cell signaling, and fatty acid metabolism in SH rats. SO2 effects on these genes were more pronounced in SH than in SD rats. Thus, SO2 exposure in SH rats may yield a relevant experimental model of bronchitis.
C1 US EPA, Natl Hlth & Environm Effects Res Lab, Expt Toxicol Div, Pulm Toxicol Branch,Off Res & Dev, Res Triangle Pk, NC 27711 USA.
   Univ Calif Davis, Ctr Hlth & Environm, Davis, CA 95616 USA.
   US EPA, Natl Hlth & Environm Effects Res Lab, Human Studies Div, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
   Univ N Carolina, Sch Med, Ctr Environm Med Asthma & Lung Biol, Chapel Hill, NC 27599 USA.
C3 United States Environmental Protection Agency; University of California
   System; University of California Davis; United States Environmental
   Protection Agency; University of North Carolina School of Medicine;
   University of North Carolina; University of North Carolina Chapel Hill
RP Kodavanti, UP (corresponding author), US EPA, Natl Hlth & Environm Effects Res Lab, Expt Toxicol Div, Pulm Toxicol Branch,Off Res & Dev, MD B143-01,109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA.
EM kodavanti.urmila@epa.gov
RI Costa, Daniel/KJK-3910-2024; Huang, Yuhchin/ABF-8127-2021; Gilmour,
   Peter/JZT-1925-2024
OI Gilmour, Peter S./0000-0003-3242-6965
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NR 57
TC 26
Z9 35
U1 0
U2 9
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1096-6080
J9 TOXICOL SCI
JI Toxicol. Sci.
PD NOV
PY 2006
VL 94
IS 1
BP 193
EP 205
DI 10.1093/toxsci/kfl087
PG 13
WC Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Toxicology
GA 092KL
UT WOS:000241095300019
PM 16929007
OA Green Submitted, Bronze
DA 2025-06-11
ER

PT J
AU Cho, YE
   Kim, DK
   Seo, W
   Gao, B
   Yoo, SH
   Song, BJ
AF Cho, Young-Eun
   Kim, Do-Kyun
   Seo, Wonhyo
   Gao, Bin
   Yoo, Seong-Ho
   Song, Byoung-Joon
TI Fructose Promotes Leaky Gut, Endotoxemia, and Liver Fibrosis Through
   Ethanol-Inducible Cytochrome P450-2E1-Mediated Oxidative and Nitrative
   Stress
SO HEPATOLOGY
LA English
DT Article
ID HIGH-FAT; LIPID-ACCUMULATION; INSULIN-RESISTANCE; HEPATIC STEATOSIS;
   ALCOHOL; STEATOHEPATITIS; CYP2E1; CONSUMPTION; DISEASE; DIET
AB Fructose intake is known to induce obesity, insulin resistance, metabolic syndrome, and nonalcoholic fatty liver disease (NAFLD). We aimed to evaluate the effects of fructose drinking on gut leakiness, endotoxemia, and NAFLD and study the underlying mechanisms in rats, mice, and T84 colon cells. Levels of ileum junctional proteins, oxidative stress markers, and apoptosis-related proteins in rodents, T84 colonic cells, and human ileums were determined by immunoblotting, immunoprecipitation, and immunofluorescence analyses. Fructose drinking caused microbiome change, leaky gut, and hepatic inflammation/fibrosis with increased levels of nitroxidative stress marker proteins cytochrome P450-2E1 (CYP2E1), inducible nitric oxide synthase, and nitrated proteins in small intestine and liver of rodents. Fructose drinking significantly elevated plasma bacterial endotoxin levels, likely resulting from decreased levels of intestinal tight junction (TJ) proteins (zonula occludens 1, occludin, claudin-1, and claudin-4), adherent junction (AJ) proteins (beta-catenin and E-cadherin), and desmosome plakoglobin, along with alpha-tubulin, in wild-type rodents, but not in fructose-exposed Cyp2e1-null mice. Consistently, decreased intestinal TJ/AJ proteins and increased hepatic inflammation with fibrosis were observed in autopsied obese people compared to lean individuals. Furthermore, histological and biochemical analyses showed markedly elevated hepatic fibrosis marker proteins in fructose-exposed rats compared to controls. Immunoprecipitation followed by immunoblot analyses revealed that intestinal TJ proteins were nitrated and ubiquitinated, leading to their decreased levels in fructose-exposed rats. Conclusion: These results showed that fructose intake causes protein nitration of intestinal TJ and AJ proteins, resulting in increased gut leakiness, endotoxemia, and steatohepatitis with liver fibrosis, at least partly, through a CYP2E1-dependent manner.
C1 [Cho, Young-Eun; Song, Byoung-Joon] NIAAA, Sect Mol Pharmacol & Toxicol, Lab Membrane Biochem & Biophys, NIH, Bethesda, MD 20892 USA.
   [Cho, Young-Eun] Andong Natl Univ, Dept Food & Nutr, Andong, South Korea.
   [Kim, Do-Kyun] NIAID, Mast Cell Biol Sect, Lab Allerg Dis, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA.
   [Seo, Wonhyo; Gao, Bin] NIAAA, Lab Liver Dis, NIH, Bethesda, MD 20892 USA.
   [Yoo, Seong-Ho] Seoul Natl Univ, Dept Forens Med, Coll Med, Seoul, South Korea.
C3 National Institutes of Health (NIH) - USA; NIH National Institute on
   Alcohol Abuse & Alcoholism (NIAAA); Gyeongkuk National University;
   National Institutes of Health (NIH) - USA; NIH National Institute of
   Allergy & Infectious Diseases (NIAID); National Institutes of Health
   (NIH) - USA; NIH National Institute on Alcohol Abuse & Alcoholism
   (NIAAA); Seoul National University (SNU)
RP Song, BJ (corresponding author), NIAAA, Lab Membrane Biochem & Biophys, 9000 Rockville Pike, Bethesda, MD 20892 USA.
EM bj.song@nih.gov
RI gao, bin/JYW-5418-2024; kim, david/AAA-4537-2020; Yoo, Sung/J-5549-2012;
   Wang, Xiaolin/ADQ-6971-2022
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NR 45
TC 166
Z9 172
U1 11
U2 130
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0270-9139
EI 1527-3350
J9 HEPATOLOGY
JI Hepatology
PD JUN
PY 2021
VL 73
IS 6
BP 2180
EP 2195
DI 10.1002/hep.30652
PG 16
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA SU5AL
UT WOS:000663150100010
PM 30959577
OA Green Accepted
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Sampath, C
   Wilus, D
   Tabatabai, M
   Freeman, ML
   Gangula, PR
AF Sampath, Chethan
   Wilus, Derek
   Tabatabai, Mohammad
   Freeman, Michael L.
   Gangula, Pandu R.
TI Mechanistic role of antioxidants in rescuing delayed gastric emptying in
   high fat diet induced diabetic female mice
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Article
DE Cinnamaldehyde; Curcumin; Nitrergic relaxation; Gastric emptying;
   Inflammation; Nrf2; nNOS
ID ARYL-HYDROCARBON RECEPTOR; NITRIC-OXIDE SYNTHASE; TRANSCRIPTION FACTOR
   NRF2; TOLL-LIKE RECEPTORS; ESTROGEN-RECEPTOR; METABOLIC SYNDROME;
   OXIDATIVE STRESS; CROSS-TALK; CINNAMALDEHYDE; GASTROPARESIS
AB Diabetic gastroparesis (DG) exhibits delayed gastric emptying (GE) due to impaired gastric non-adrenergic, non-cholinergic (NANC) relaxation. These defects are due to loss or reduction of nuclear factor (erythroid-derived 2)-like 2 (Nrf2) that causes reduced expression and/or dimerization of neuronal nitric oxide synthase alpha (nNOS alpha) gene expression and function. We investigated the effect of potent Nrf2 activators (cinnamaldehyde [CNM] & curcumin [CUR]) on GE in obesity-induced diabetic female mice. We fed adult female homozygous Nfe2l2(-/-) (Nrf2 KO) and wild-type (WT) female mice with either a high-fat diet (HFD) or a normal diet (ND) for a period of 16 weeks. Groups of HFD mice were fed with CUR or CNM either at 6th or 10th week respectively. Our results demonstrate that supplementation of CNM or CUR restored impaired nitrergic relaxation and attenuated delayed GE in HFD fed mice. Supplementation of CNM or CUR normalized altered gastric antrum protein expression of (1) p-ERK/p-JNK/MAPK/p-GSK-3 beta, (2) BH4 (Cofactor of nNOS) biosynthesis enzyme GCH-1 and the GSH/GSSG ratio, (3) nNOSa protein & dimerization and soluble guanylate cyclase (sGC), (4) AhR and ER expression, (5) inflammatory cytokines (TNF alpha, IL-1 beta, IL-6), (6)TLR-4, as well as (7) reduced oxidative stress markers in WT but not in Nrf2 KO obesity-induced chronic diabetic female mice. Immunoprecipitation experiments revealed an interaction between nNOS and Nrf2 proteins. Our results conclude that Nrf2 activation restores nitrergic-mediated gastric motility and GE by normalizing inflammation and oxidative stress induced by obesity-induced chronic diabetes.
C1 [Sampath, Chethan; Gangula, Pandu R.] Meharry Med Coll, Sch Dent, Dept ODS & Res, 1005 Dr DB Todd Jr Blvd, Nashville, TN 37208 USA.
   [Wilus, Derek; Tabatabai, Mohammad] Meharry Med Coll, Sch Grad Studies & Res, Biostat, Nashville, TN 37208 USA.
   [Freeman, Michael L.] Vanderbilt Univ, Med Ctr, Dept Radiat Oncol, Nashville, TN USA.
C3 Meharry Medical College; Meharry Medical College; Vanderbilt University
RP Gangula, PR (corresponding author), Meharry Med Coll, Sch Dent, Dept ODS & Res, 1005 Dr DB Todd Jr Blvd, Nashville, TN 37208 USA.
EM pgangala@mmc.edu
RI Sampath, Chethan/AAX-7521-2020
FU National Institute of General Medical Sciences (NIGMS) of the National
   Institutes of Health (NIH) [SC1GM121282]; NIH [S21MD000104]; Meharry
   Medical College RCMI grant (NIH) [MD007586]; National Institute on
   Minority Health and Health Disparities [NIMHD U54MD007586]
FX The National Institute of General Medical Sciences (NIGMS) of the
   National Institutes of Health (NIH) (award SC1GM121282 to PG) supported
   this research. The Meharry Office of Scientific Editing and Publications
   (NIH S21MD000104) provided editing services. The Meharry Medical College
   RCMI grant (NIH grant MD007586) supported the following authors: Dr.
   Tabatabai and Mr. Wilus. The National Institute on Minority Health and
   Health Disparities (NIMHD U54MD007586) for supporting manuscript
   publication charges.
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NR 91
TC 16
Z9 18
U1 0
U2 15
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD MAY
PY 2021
VL 137
AR 111370
DI 10.1016/j.biopha.2021.111370
EA FEB 2021
PG 20
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA RF3PC
UT WOS:000634752600005
PM 33761597
OA Green Accepted, gold
DA 2025-06-11
ER

PT J
AU Jia, GH
   Habibi, J
   Bostick, BP
   Ma, LX
   DeMarco, VG
   Aroor, AR
   Hayden, MR
   Whaley-Connell, AT
   Sowers, JR
AF Jia, Guanghong
   Habibi, Javad
   Bostick, Brian P.
   Ma, Lixin
   DeMarco, Vincent G.
   Aroor, Annayya R.
   Hayden, Melvin R.
   Whaley-Connell, Adam T.
   Sowers, James R.
TI Uric Acid Promotes Left Ventricular Diastolic Dysfunction in Mice Fed a
   Western Diet
SO HYPERTENSION
LA English
DT Article
DE cardiac remodeling; inflammation; obesity; uric acid
ID CHRONIC HEART-FAILURE; INCREASED CARDIOVASCULAR RISK;
   GROWTH-FACTOR-BETA; METABOLIC SYNDROME; INSULIN-RESISTANCE; OXIDATIVE
   STRESS; BLOOD-PRESSURE; ENDOTHELIAL FUNCTION; FRUCTOSE; HYPERURICEMIA
AB The rising obesity rates parallel increased consumption of a Western diet, high in fat and fructose, which is associated with increased uric acid. Population-based data support that elevated serum uric acids are associated with left ventricular hypertrophy and diastolic dysfunction. However, the mechanism by which excess uric acid promotes these maladaptive cardiac effects has not been explored. In assessing the role of Western diet-induced increases in uric acid, we hypothesized that reductions in uric acid would prevent Western diet-induced development of cardiomyocyte hypertrophy, cardiac stiffness, and impaired diastolic relaxation by reducing growth and profibrotic signaling pathways. Four-weeks-old C57BL6/J male mice were fed excess fat (46%) and fructose (17.5%) with or without allopurinol (125 mg/L), a xanthine oxidase inhibitor, for 16 weeks. The Western diet-induced increases in serum uric acid along with increases in cardiac tissue xanthine oxidase activity temporally related to increases in body weight, fat mass, and insulin resistance without changes in blood pressure. The Western diet induced cardiomyocte hypertrophy, myocardial oxidative stress, interstitial fibrosis, and impaired diastolic relaxation. Further, the Western diet enhanced activation of the S6 kinase-1 growth pathway and the profibrotic transforming growth factor-beta 1/Smad2/3 signaling pathway and macrophage proinflammatory polarization. All results improved with allopurinol treatment, which lowered cardiac xanthine oxidase as well as serum uric acid levels. These findings support the notion that increased production of uric acid with intake of a Western diet promotes cardiomyocyte hypertrophy, inflammation, and oxidative stress that lead to myocardial fibrosis and associated impaired diastolic relaxation.
C1 [Jia, Guanghong; Habibi, Javad; Bostick, Brian P.; DeMarco, Vincent G.; Aroor, Annayya R.; Hayden, Melvin R.; Whaley-Connell, Adam T.; Sowers, James R.] Univ Missouri Sch Med, Div Endocrinol & Metab, Dept Med, Columbia, MO 65212 USA.
   [Whaley-Connell, Adam T.] Univ Missouri Sch Med, Div Nephrol & Hypertens, Dept Med, Columbia, MO 65212 USA.
   [DeMarco, Vincent G.; Sowers, James R.] Univ Missouri Sch Med, Dept Med Pharmacol & Physiol, Columbia, MO 65212 USA.
   [Jia, Guanghong; Habibi, Javad; Bostick, Brian P.; DeMarco, Vincent G.; Aroor, Annayya R.; Hayden, Melvin R.; Whaley-Connell, Adam T.; Sowers, James R.] Univ Missouri Sch Med, Diabet & Cardiovasc Ctr, Columbia, MO 65212 USA.
   [Ma, Lixin] Univ Missouri Sch Med, Dept Radiol, Columbia, MO 65212 USA.
   [Jia, Guanghong; Habibi, Javad; Bostick, Brian P.; Ma, Lixin; DeMarco, Vincent G.; Aroor, Annayya R.; Hayden, Melvin R.; Whaley-Connell, Adam T.; Sowers, James R.] Harry S Truman Mem Vet Hosp, Res Serv, Columbia, MO 65201 USA.
C3 University of Missouri System; University of Missouri Columbia;
   University of Missouri System; University of Missouri Columbia;
   University of Missouri System; University of Missouri Columbia;
   University of Missouri System; University of Missouri Columbia;
   University of Missouri System; University of Missouri Columbia; US
   Department of Veterans Affairs; Veterans Health Administration (VHA);
   Harry S. Truman Memorial Veterans' Hospital
RP Sowers, JR (corresponding author), Univ Missouri, Diabet Ctr HSC D109, 1 Hosp Dr, Columbia, MO 65212 USA.
EM sowersj@health.missouri.edu
OI Whaley-Connell, Adam/0000-0001-8955-5560; DeMarco,
   Vincent/0000-0003-2092-9995; Ma, Lixin/0000-0003-2171-1226
FU National Institute of Health [R01 HL73101-01A, R01 HL107910-01];
   Veterans Affairs Merit System [0018]
FX We thank Brenda Hunter for her editorial assistance. This research was
   supported by National Institute of Health (R01 HL73101-01A, R01
   HL107910-01) and the Veterans Affairs Merit System (0018) for J.R.
   Sowers.
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NR 46
TC 117
Z9 124
U1 4
U2 20
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0194-911X
EI 1524-4563
J9 HYPERTENSION
JI Hypertension
PD MAR
PY 2015
VL 65
IS 3
BP 531
EP U89
DI 10.1161/HYPERTENSIONAHA.114.04737
PG 13
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA CB6CX
UT WOS:000349715600011
PM 25489061
OA Green Accepted
DA 2025-06-11
ER

PT J
AU García-Ruiz, C
   Baulies, A
   Mari, M
   García-Rovés, PM
   Fernandez-Checa, JC
AF Garcia-Ruiz, C.
   Baulies, A.
   Mari, M.
   Garcia-Roves, P. M.
   Fernandez-Checa, J. C.
TI Mitochondrial dysfunction in non-alcoholic fatty liver disease and
   insulin resistance: Cause or consequence?
SO FREE RADICAL RESEARCH
LA English
DT Review
DE mitochondria; TCA cycle; oxidative stress; insulin signaling; hepatic
   steatosis; steatohepatitis; insulin resistance; fatty acid oxidation
ID APOPTOSIS-INDUCING FACTOR; PHOSPHATIDYLINOSITOL 3-KINASE ACTIVITY;
   ENDOPLASMIC-RETICULUM STRESS; HUMAN SKELETAL-MUSCLE; PROTEIN-KINASE-C;
   OXIDATIVE STRESS; ACID OXIDATION; MALONYL-COA; ANTIOXIDANT
   SUPPLEMENTATION; SIGNALING PATHWAYS
AB Non-alcoholic fatty liver disease (NAFLD) is considered the hepatic manifestation of the metabolic syndrome and refers to a spectrum of disorders ranging from steatosis to steatohepatitis, a disease stage characterized by inflammation, fibrosis, cell death and insulin resistance (IR). Due to its association with obesity and IR the impact of NAFLD is growing worldwide. Consistent with the role of mitochondria in fatty acid (FA) metabolism, impaired mitochondrial function is thought to contribute to NAFLD and IR. Indeed, mitochondrial dysfunction and impaired mitochondrial respiratory chain have been described in patients with non-alcoholic steatohepatitis and skeletal muscle of obese patients. However, recent data have provided evidence that pharmacological and genetic models of mitochondrial impairment with reduced electron transport stimulate insulin sensitivity and protect against diet-induced obesity, hepatosteatosis and IR. These beneficial metabolic effects of impaired mitochondrial oxidative phosphorylation may be related not only to the reduction of reactive oxygen species production that regulate insulin signaling but also to decreased mitochondrial FA overload that generate specific metabolites derived from incomplete FA oxidation (FAO) in the TCA cycle. In line with the Randle cycle, reduced mitochondrial FAO rates may alleviate the repression on glucose metabolism in obesity. In addition, the redox paradox in insulin signaling and the delicate mitochondrial antioxidant balance in steatohepatitis add another level of complexity to the role of mitochondria in NAFLD and IR. Thus, better understanding the role of mitochondria in FA metabolism and glucose homeostasis may provide novel strategies for the treatment of NAFLD and IR.
C1 [Garcia-Ruiz, C.; Baulies, A.; Mari, M.; Fernandez-Checa, J. C.] CSIC, Dept Cell Death & Proliferat, Inst Biomed Res Barcelona IIBB, Barcelona, Spain.
   [Garcia-Ruiz, C.; Baulies, A.; Mari, M.; Fernandez-Checa, J. C.] Hosp Clin Barcelona, Liver Unit, Barcelona, Spain.
   [Garcia-Ruiz, C.; Baulies, A.; Mari, M.; Fernandez-Checa, J. C.] CIBEREHD, Barcelona, Spain.
   [Garcia-Roves, P. M.] Hosp Clin Barcelona, IDIBAPS, Diabet & Obes Lab, Barcelona, Spain.
   [Fernandez-Checa, J. C.] Univ So Calif, Keck Sch Med, Southern Calif Res Ctr ALPD & Cirrhosis, Los Angeles, CA 90033 USA.
C3 Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Instituto
   de Investigaciones Biomedicas de Barcelona (IIBB); University of
   Barcelona; Hospital Clinic de Barcelona; CIBER - Centro de Investigacion
   Biomedica en Red; CIBEREHD; University of Barcelona; Hospital Clinic de
   Barcelona; IDIBAPS; University of Southern California
RP Fernandez-Checa, JC (corresponding author), CSIC, Dept Cell Death & Proliferat, Inst Biomed Res Barcelona IIBB, Barcelona, Spain.
EM checa229@yahoo.com
RI Roves, Pablo/A-7113-2015; Baulies, Anna/M-1108-2014; ,
   Carmen/L-8211-2014; MARI, MONTSERRAT/A-7376-2013; Fernandez-Checa, Jose
   Carlos/L-8342-2014; Garcia-Roves, Pablo M./X-4585-2018
OI , Carmen/0000-0002-2652-6102; MARI, MONTSERRAT/0000-0002-6116-3247;
   Fernandez-Checa, Jose Carlos/0000-0003-3422-2990; Garcia-Roves, Pablo
   M./0000-0002-8371-2067
FU CIBEREHD; Fundacio la Marato de TV3; Fundacion Mutua Madrile a; Plan
   Nacional de I + D [SAF2010-15760, SAF2011-23031, SAF2012-34831];
   Instituto Salud Carlos III, Spain [PI11/0325]; NIAAA/NIH [P50-AA-11999]
FX This work was supported by CIBEREHD, Fundacio la Marato de TV3,
   Fundacion Mutua Madrile a, and grants SAF2010-15760, SAF2011-23031,
   SAF2012-34831 (Plan Nacional de I + D), and grant PI11/0325 (META) from
   Instituto Salud Carlos III, Spain; and P50-AA-11999 from the Research
   Center for Liver and Pancreatic Diseases supported by NIAAA/NIH.
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NR 133
TC 86
Z9 98
U1 0
U2 45
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1071-5762
EI 1029-2470
J9 FREE RADICAL RES
JI Free Radic. Res.
PD NOV
PY 2013
VL 47
IS 11
SI SI
BP 854
EP 868
DI 10.3109/10715762.2013.830717
PG 15
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 235YX
UT WOS:000325760700002
PM 23915028
DA 2025-06-11
ER

PT J
AU Choi, JS
   Koh, IU
   Lee, HJ
   Kim, WH
   Song, J
AF Choi, Joo Sun
   Koh, In-Uk
   Lee, Hyo Jung
   Kim, Won Ho
   Song, Jihyun
TI Effects of excess dietary iron and fat on glucose and lipid metabolism
SO JOURNAL OF NUTRITIONAL BIOCHEMISTRY
LA English
DT Article
DE High-fat diet; Iron overload; Insulin resistance; Hepcidin; Hepatic
   steatosis
ID SERUM FERRITIN CONCENTRATION; INSULIN-RESISTANCE; HEREDITARY
   HEMOCHROMATOSIS; REGULATORY PEPTIDE; OXIDATIVE STRESS; HEPATOMA-CELLS;
   ADIPOSE-TISSUE; HEPCIDIN; LIVER; OBESITY
AB Purpose: Diets rich in fat and energy are associated with metabolic syndrome (MS). Increased body iron stores have been recognized as a feature of MS. High-fat diets (HFs), excess iron loading and MS are closely associated, but the mechanism linking them has not been clearly defined. We investigated the interaction between dietary fat and dietary Fe in the context of glucose and lipid metabolism in the body.
   Methods: C57BL6/J mice were divided into four groups and fed the modified AIN-93G low-fat diet (LF) and HF with adequate or excess Fe for 7 weeks. The Fe contents were increased by adding carbonyl iron (2% of diet weight) (LF+Fe and HF+Fe).
   Results: High iron levels increased blood glucose levels but decreased high-density lipoprotein cholesterol levels. The HF group showed increases in plasma levels of glucose and insulin and insulin resistance. HF+Fe mice showed greater changes. Representative indices of iron status, such hepatic and plasma Fe levels, were not altered further by the HF. However, both the HF and excess iron loading changed the hepatic expression of hepcidin and ferroportin. The LF+Fe, HF and HF+Fe groups showed greater hepatic fat accumulation compared with the LF group. These changes were paralleled by alterations in the levels of enzymes related to hepatic gluconeogenesis and lipid synthesis, which could be due to increases in mitochondrial dysfunction and oxidative stress.
   Conclusions: High-fat diets and iron overload are associated with insulin resistance, modified hepatic lipid and iron metabolism and increased mitochondrial dysfunction and oxidative stress. (C) 2013 Elsevier Inc. All rights reserved.
C1 [Choi, Joo Sun; Koh, In-Uk; Lee, Hyo Jung; Kim, Won Ho; Song, Jihyun] Korea Natl Inst Hlth, Ctr Biomed Sci, Div Metab Dis, Chungbuk Do 363951, South Korea.
C3 Korea Disease Control & Prevention Agency (KDCA); Korea National
   Institute of Health (KNIH); Korea CDC Center for Biomedical Science
RP Song, J (corresponding author), Korea Natl Inst Hlth, Ctr Biomed Sci, Div Metab Dis, 187 Osongsaengmyeong 2 Ro, Cheongwon Gun 363951, Chungcheongbuk, South Korea.
EM jhsong10@korea.kr
RI Lee, Hyo/G-6299-2019; Kim, Wooho/G-3703-2011
OI KOH, IN-UK/0009-0002-9288-2305; Kim, Won-Ho/0000-0002-4849-472X; CHOI,
   JOO SUN/0000-0001-8650-0783; song, jihyun/0000-0003-0420-2374
FU Korea National Institute of Health [4845-302-210-13]
FX This work was supported in part by a Korea National Institute of Health
   intramural research grant (4845-302-210-13). No conflicts of interest
   are declared by the authors.
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NR 41
TC 68
Z9 74
U1 2
U2 37
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0955-2863
EI 1873-4847
J9 J NUTR BIOCHEM
JI J. Nutr. Biochem.
PD SEP
PY 2013
VL 24
IS 9
BP 1634
EP 1644
DI 10.1016/j.jnutbio.2013.02.004
PG 11
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA 204XP
UT WOS:000323404900011
PM 23643521
DA 2025-06-11
ER

PT J
AU Luca, F
   Kashyap, S
   Southard, C
   Zou, M
   Witonsky, D
   Di Rienzo, A
   Conzen, SD
AF Luca, Francesca
   Kashyap, Sonal
   Southard, Catherine
   Zou, Min
   Witonsky, David
   Di Rienzo, Anna
   Conzen, Suzanne D.
TI Adaptive Variation Regulates the Expression of the Human SGK1
   Gene in Response to Stress
SO PLOS GENETICS
LA English
DT Article
ID GENOME-WIDE ASSOCIATION; THREONINE PROTEIN-KINASE; MAMMARY
   EPITHELIAL-CELLS; GLUCOCORTICOID-RECEPTOR; POSITIVE SELECTION;
   NATURAL-SELECTION; METABOLIC SYNDROME; BINDING-SITES; HAPLOTYPE MAP;
   CHIP-CHIP
AB The Serum and Glucocorticoid-regulated Kinase1 (SGK1) gene is a target of the glucocorticoid receptor (GR) and is central to the stress response in many human tissues. Because environmental stress varies across habitats, we hypothesized that natural selection shaped the geographic distribution of genetic variants regulating the level of SGK1 expression following GR activation. By combining population genetics and molecular biology methods, we identified a variant (rs9493857) with marked allele frequency differences between populations of African and European ancestry and with a strong correlation between allele frequency and latitude in worldwide population samples. This SNP is located in a GR-binding region upstream of SGK1 that was identified using a GR ChIP-chip. SNP rs9493857 also lies within a predicted binding site for Oct1, a transcription factor known to cooperate with the GR in the transactivation of target genes. Using ChIP assays, we show that both GR and Oct1 bind to this region and that the ancestral allele at rs9493857 binds the GR-Oct1 complex more efficiently than the derived allele. Finally, using a reporter gene assay, we demonstrate that the ancestral allele is associated with increased glucocorticoid-dependent gene expression when compared to the derived allele. Our results suggest a novel paradigm in which hormonal responsiveness is modulated by sequence variation in the regulatory regions of nuclear receptor target genes. Identifying such functional variants may shed light on the mechanisms underlying inter-individual variation in response to environmental stressors and to hormonal therapy, as well as in the susceptibility to hormone-dependent diseases.
C1 [Luca, Francesca; Southard, Catherine; Witonsky, David; Di Rienzo, Anna] Univ Chicago, Dept Human Genet, Chicago, IL 60637 USA.
   [Kashyap, Sonal; Zou, Min; Conzen, Suzanne D.] Univ Chicago, Dept Med, Chicago, IL 60637 USA.
C3 University of Chicago; University of Chicago
RP Luca, F (corresponding author), Univ Chicago, Dept Human Genet, Chicago, IL 60637 USA.
EM dirienzo@genetics.bsd.uchicago.edu; sdconzen@uchicago.edu
RI Luca, Francesca/B-4850-2019
OI Luca, Francesca/0000-0001-8252-9052; Di Rienzo, Anna/0000-0002-8982-9098
FU NIH [R01 DK056670, P50 CA125183, R01 CA089208]; University of Chicago
   Cancer Research Center [P30CA014599]; Blanceflor Foundation; American
   Heart Association postdoctoral fellowship [090073G]; MRC [G0000934]
   Funding Source: UKRI
FX This work was funded by NIH grants R01 DK056670 (ADR), P50 CA125183 (ADR
   and SDC), a supplement to R01 CA089208 (SDC) and by both pilot and core
   facility funding from the University of Chicago Cancer Research Center
   Support Grant P30CA014599. FL was partially supported by a Blanceflor
   Foundation Grant for post-graduate studies and an American Heart
   Association postdoctoral fellowship (090073G). The funders had no role
   in study design, data collection and analysis, decision to publish, or
   preparation of the manuscript.
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NR 91
TC 36
Z9 40
U1 0
U2 8
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA
SN 1553-7390
J9 PLOS GENET
JI PLoS Genet.
PD MAY
PY 2009
VL 5
IS 5
AR e1000489
DI 10.1371/journal.pgen.1000489
PG 11
WC Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Genetics & Heredity
GA 459EH
UT WOS:000267083000011
PM 19461886
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Losasso, MR
   Parussolo, MLC
   Silva, A
   Direito, R
   Quesada, K
   Detregiachi, CRP
   Bechara, MD
   Méndez-Sánchez, N
   Abenavoli, L
   Araújo, AC
   Goulart, RD
   Guiger, EL
   Laurindo, LF
   Barbalho, SM
AF Losasso, Marina Ribas
   Parussolo, Maria Luiza Cesto
   Silva, Antony Oliveira
   Direito, Rosa
   Quesada, Karina
   Detregiachi, Claudia Rucco Penteado
   Bechara, Marcelo Dib
   Mendez-Sanchez, Nahum
   Abenavoli, Ludovico
   Araujo, Adriano Cressoni
   de Alvares Goulart, Ricardo
   Guiger, Elen Landgraf
   Laurindo, Lucas Fornari
   Barbalho, Sandra Maria
TI Unraveling the Metabolic Pathways Between Metabolic-Associated Fatty
   Liver Disease (MAFLD) and Sarcopenia
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE metabolic-associated fatty liver disease; MAFLD; liver disease;
   sarcopenia; cardiovascular diseases; metabolic diseases
ID INDEPENDENT RISK-FACTOR; OXIDATIVE STRESS; MITOCHONDRIAL DYSFUNCTION;
   INSULIN-RESISTANCE; MUSCLE STRENGTH; INFLAMMATION; FIBROSIS; OBESITY;
   NAFLD; PATHOGENESIS
AB Metabolic-Associated Fatty Liver Disease (MAFLD) is a public health concern that is constantly expanding, with a fast-growing prevalence, and it affects about a quarter of the world's population. This condition is a significant risk factor for cardiovascular, hepatic, and oncologic diseases, such as hypertension, hepatoma, and atherosclerosis. Sarcopenia was long considered to be an aging-related syndrome, but today, it is acknowledged to be secondarily related to chronic diseases such as metabolic syndrome, cardiovascular conditions, and liver diseases, among other comorbidities associated with insulin resistance and chronic inflammation, besides inactivity and poor nutrition. The physiopathology involving MAFLD and sarcopenia has still not been solved. Inflammation, oxidative stress, mitochondrial dysfunction, and insulin resistance seem to be some of the keys to this relationship since this hormone target is mainly the skeletal muscle. This review aimed to comprehensively discuss the main metabolic and physiological pathways involved in these conditions. MAFLD and sarcopenia are interconnected by a complex network of pathophysiological mechanisms, such as insulin resistance, skeletal muscle tissue production capacity, chronic inflammatory state, oxidative stress, and mitochondrial dysfunction, which are the main contributors to this relationship. In addition, in a clinical analysis, patients with sarcopenia and MAFLD manifest more severe hepatitis fibrosis when compared to patients with only MAFLD. These patients, with both disorders, also present clinical improvement in their MAFLD when treated for sarcopenia, reinforcing the association between them. Lifestyle changes accompanied by non-pharmacological interventions, such as dietary therapy and increased physical activity, undoubtedly improve this scenario.
C1 [Losasso, Marina Ribas; Parussolo, Maria Luiza Cesto; Silva, Antony Oliveira; Quesada, Karina; Detregiachi, Claudia Rucco Penteado; Bechara, Marcelo Dib; Araujo, Adriano Cressoni; de Alvares Goulart, Ricardo; Guiger, Elen Landgraf; Laurindo, Lucas Fornari; Barbalho, Sandra Maria] Univ Marilia UNIMAR, Sch Med, Dept Biochem & Pharmacol, BR-17525902 Marilia, SP, Brazil.
   [Direito, Rosa] Univ Lisboa iMed ULisboa, Res Inst Med, Lab Syst Integrat Pharmacol Clin & Regulatory Sci, Ave Prof Gama Pinto, P-1649003 Lisbon, Portugal.
   [Detregiachi, Claudia Rucco Penteado; Bechara, Marcelo Dib; Araujo, Adriano Cressoni; de Alvares Goulart, Ricardo; Guiger, Elen Landgraf; Laurindo, Lucas Fornari; Barbalho, Sandra Maria] Univ Marilia UNIMAR, Sch Med, Postgrad Program Struct & Funct Interact Rehabil, BR-17525902 Marilia, SP, Brazil.
   [Mendez-Sanchez, Nahum] Med Sur Clin & Fdn, Liver Res Unit, Mexico City 14050, Mexico.
   [Mendez-Sanchez, Nahum] Univ Nacl Autonoma Mexico, Fac Med, Mexico City 04510, Mexico.
   [Abenavoli, Ludovico] Magna Graecia Univ Catanzaro, Dept Hlth Sci, Viale Europa, I-88100 Catanzaro, Italy.
   [Barbalho, Sandra Maria] Sch Food & Technol Marilia FATEC, Dept Biochem & Nutr, BR-17500000 Marilia, SP, Brazil.
   [Barbalho, Sandra Maria] Univ Marilia UNIMAR, UNIMAR Char Hosp, BR-17525902 Marilia, SP, Brazil.
C3 Universidade de Marilia; Universidade de Marilia; Universidad Nacional
   Autonoma de Mexico; Magna Graecia University of Catanzaro; Universidade
   de Marilia
RP Laurindo, LF; Barbalho, SM (corresponding author), Univ Marilia UNIMAR, Sch Med, Dept Biochem & Pharmacol, BR-17525902 Marilia, SP, Brazil.; Laurindo, LF; Barbalho, SM (corresponding author), Univ Marilia UNIMAR, Sch Med, Postgrad Program Struct & Funct Interact Rehabil, BR-17525902 Marilia, SP, Brazil.; Barbalho, SM (corresponding author), Sch Food & Technol Marilia FATEC, Dept Biochem & Nutr, BR-17500000 Marilia, SP, Brazil.; Barbalho, SM (corresponding author), Univ Marilia UNIMAR, UNIMAR Char Hosp, BR-17525902 Marilia, SP, Brazil.
EM lucasffffor@gmail.com; smbarbalho@gmail.com
RI Abenavoli, Ludovico/J-4394-2019; Landgraf Guiguer, Elen/AAN-1883-2020;
   FORNARI LAURINDO, LUCAS/HZJ-7263-2023; Direito, Rosa/S-4473-2019;
   barbalho, sandra/Z-3515-2019
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NR 242
TC 0
Z9 0
U1 0
U2 0
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD MAY 14
PY 2025
VL 26
IS 10
AR 4673
DI 10.3390/ijms26104673
PG 29
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 3BH6U
UT WOS:001496249600001
PM 40429815
DA 2025-06-11
ER

PT J
AU Lee, GH
   Lee, HY
   Lim, YJ
   Kim, JH
   Jung, SJ
   Jung, ES
   Chae, SW
   Lee, J
   Lim, J
   Rashid, MMU
   Min, KH
   Chae, HJ
AF Lee, Geum-Hwa
   Lee, Hwa-Young
   Lim, Young-Je
   Kim, Ji-Hyun
   Jung, Su-Jin
   Jung, Eun-Soo
   Chae, Soo-Wan
   Lee, Juwon
   Lim, Junghyun
   Rashid, Mohammad Mamun Ur
   Min, Kyung Hyun
   Chae, Han-Jung
TI Angelica gigas extract inhibits acetylation of eNOS via
   IRE1α sulfonation/RIDD-SIRT1-mediated posttranslational modification in
   vascular dysfunction
SO AGING-US
LA English
DT Article
DE Angelica gigas; decursin; IRE1 alpha sulfonation; RIDD; SIRT1; vascular
   dysfunction
ID NITRIC-OXIDE; CARDIOVASCULAR-DISEASE; HEPATIC STEATOSIS; ACTIVATION;
   SIRT1; PROTECTS; STRESS; MODELS; ROLES; AORTA
AB Angelica gigas NAKAI (AG) is a popular traditional medicinal herb widely used to treat dyslipidemia owing to its antioxidant activity. Vascular disease is intimately linked to obesity-induced metabolic syndrome, and AG extract (AGE) shows beneficial effects on obesity-associated vascular dysfunction. However, the effectiveness of AGE against obesity and its underlying mechanisms have not yet been extensively investigated. In this study, 40 high fat diet (HFD) rats were supplemented with 100-300 mg/kg/day of AGE to determine its efficacy in regulating vascular dysfunction. The vascular relaxation responses to acetylcholine were impaired in HFD rats, while the administration of AGE restored the diminished relaxation pattern. Endothelial dysfunction, including increased plaque area, accumulated reactive oxygen species, and decreased nitric oxide (NO) and endothelial nitric oxide synthase (eNOS) Ser1177 phosphorylation, were observed in HFD rats, whereas AGE reversed endothelial dysfunction and its associated biochemical signaling. Furthermore, AGE regulated endoplasmic reticulum (ER) stress and IRE1 alpha sulfonation and its subsequent sirt1 RNA decay through controlling regulated IRE1 alpha-dependent decay (RIDD) signaling, ultimately promoting NO bioavailability via the SIRT1-eNOS axis in aorta and endothelial cells. Independently, AGE enhanced AMPK phosphorylation, additionally stimulating SIRT1 and eNOS deacetylation and its associated NO bioavailability. Decursin, a prominent constituent of AGE, exhibited a similar effect in alleviating endothelial dysfunctions. These data suggest that AGE regulates dyslipidemia-associated vascular dysfunction by controlling ROS-associated ER stress responses, especially IRE1 alpha-RIDD/sirt1 decay and the AMPK-SIRT1 axis.
C1 [Lee, Geum-Hwa; Lee, Hwa-Young; Jung, Su-Jin; Jung, Eun-Soo; Chae, Han-Jung] Jeonbuk Natl Univ, Jeonbuk Natl Univ Hosp, Biomed Res Inst, Res Inst Clin Med, Jeonju, Jeonbuk, South Korea.
   [Lee, Hwa-Young; Lim, Young-Je; Kim, Ji-Hyun; Chae, Han-Jung] Jeonbuk Natl Univ Hosp, Biomed Res Inst, Nonclin Evaluat Ctr, Jeonju, South Korea.
   [Lim, Young-Je; Kim, Ji-Hyun; Lee, Juwon; Lim, Junghyun; Min, Kyung Hyun; Chae, Han-Jung] Jeonbuk Natl Univ, Sch Pharm, Jeonju, South Korea.
   [Lim, Young-Je; Kim, Ji-Hyun; Lee, Juwon; Lim, Junghyun; Min, Kyung Hyun; Chae, Han-Jung] Jeonbuk Natl Univ, Inst New Drug Dev, Jeonju, South Korea.
   [Jung, Su-Jin; Jung, Eun-Soo; Chae, Soo-Wan] Jeonbuk Natl Univ Hosp, Clin Trial Ctr Funct Foods CTCF2, Jeonju, South Korea.
   [Rashid, Mohammad Mamun Ur] Jeonbuk Natl Univ, Dept Pharmacol, Med Sch, Jeonju, South Korea.
   [Rashid, Mohammad Mamun Ur] Jeonbuk Natl Univ, Inst New Drug Dev, Med Sch, Jeonju, South Korea.
C3 Jeonbuk National University; Jeonbuk National University Hospital;
   Jeonbuk National University; Jeonbuk National University Hospital;
   Jeonbuk National University; Jeonbuk National University; Jeonbuk
   National University; Jeonbuk National University Hospital; Jeonbuk
   National University; Jeonbuk National University
RP Chae, HJ (corresponding author), Jeonbuk Natl Univ, Jeonbuk Natl Univ Hosp, Biomed Res Inst, Res Inst Clin Med, Jeonju, Jeonbuk, South Korea.; Chae, HJ (corresponding author), Jeonbuk Natl Univ Hosp, Biomed Res Inst, Nonclin Evaluat Ctr, Jeonju, South Korea.; Min, KH; Chae, HJ (corresponding author), Jeonbuk Natl Univ, Sch Pharm, Jeonju, South Korea.; Min, KH; Chae, HJ (corresponding author), Jeonbuk Natl Univ, Inst New Drug Dev, Jeonju, South Korea.
EM khmin1492@jbnu.ac.kr; hjchae@jbnu.ac.kr
RI Rashid, Mohammad Mamun Ur/KAN-3611-2024; Lim, Junghyun/AAX-3678-2021
OI Rashid, Mohammad Mamun Ur/0000-0002-7025-1716
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NR 40
TC 6
Z9 6
U1 0
U2 1
PU IMPACT JOURNALS LLC
PI ORCHARD PARK
PA 6666 E QUAKER ST, STE 1, ORCHARD PARK, NY 14127 USA
SN 1945-4589
J9 AGING-US
JI Aging-US
PD DEC 15
PY 2023
VL 15
IS 23
BP 13608
EP 13627
PG 20
WC Cell Biology; Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Geriatrics & Gerontology
GA CU0X9
UT WOS:001127645500044
PM 38095615
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Cojic, M
   Kocic, R
   Klisic, A
   Kocic, G
AF Cojic, Milena
   Kocic, Radivoj
   Klisic, Aleksandra
   Kocic, Gordana
TI The Effects of Vitamin D Supplementation on Metabolic and Oxidative
   Stress Markers in Patients With Type 2 Diabetes: A 6-Month Follow Up
   Randomized Controlled Study
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Article
DE vitamin D supplementation; HbA1c; insulin resistance; oxidative stress;
   type 2 diabetes
ID GLYCEMIC CONTROL; 1,25-DIHYDROXYVITAMIN D-3; INSULIN-RESISTANCE; LIPID
   PROFILE; D DEFICIENCY; MELLITUS; INFLAMMATION; PARAMETERS; RECEPTOR;
   CALCIUM
AB Vitamin D deficiency could play an important role in the pathogenesis of type 2 diabetes mellitus (T2DM) as it may alter several crucial processes in the development of diabetes and its complications, such as pancreatic insulin secretion, peripheral insulin resistance, persistence of systemic "sterile " inflammation and immune activation. Vitamin D may also have an antioxidant effect through the inhibition of free radicals generation. The reported study was designed with eligible consecutively recruited patients with T2DM on standard metformin therapy (n=130), randomized in 1:1 ratio, considered to have undergone Vitamin D supplementation according to the guidelines proposed by the Endocrine Society, or to have continued with metformin only. The potential benefit was monitored through the influence on glycemia level, glycated haemoglobin (HbA1c), insulin resistance index (calculated as homeostatic model assessment; HOMA-IR), Castelli Risk Index I and Tryglicerides/Thiobarbituric acid-reactive substances (TG/TBARS) Index in a 6-month follow up period. Our study indicates that oral daily doses of vitamin D improve HbA1c levels over the 3-month and 6-month period, followed by a significant decrease in advanced oxidation protein products levels over the 3-month period when higher vitamin D doses are given. The effect of vitamin D on HOMA-IR index, malondialdehyde levels and TG/TBARS index was not statistically significant. Further investigation should consider defining the doses of vitamin D in patients with T2DM which may attenuate the oxidative stress risk, the risk of metabolic syndrome and the risk of related cardiovascular events.
C1 [Cojic, Milena; Klisic, Aleksandra] Univ Montenegro, Primary Hlth Care Ctr, Fac Med, Podgorica, Montenegro.
   [Kocic, Radivoj] Univ Nis, Clin Endocrinol, Fac Med, Nish, Serbia.
   [Kocic, Gordana] Univ Nis, Inst Biochem, Fac Med, Nish, Serbia.
C3 University of Montenegro; University of Nis; University of Nis
RP Cojic, M (corresponding author), Univ Montenegro, Primary Hlth Care Ctr, Fac Med, Podgorica, Montenegro.
EM milenarovcanin@yahoo.com
RI Klisic, Aleksandra/ABC-9219-2020
FU Ministry of education, science and technological development [TR31060]
FX Funding The work was supported by the Project TR31060 (Ministry of
   education, science and technological development).
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NR 45
TC 68
Z9 71
U1 0
U2 4
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD AUG 19
PY 2021
VL 12
AR 610893
DI 10.3389/fendo.2021.610893
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA XF6UD
UT WOS:000724203900001
PM 34489860
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Mercau, ME
   Calanni, JS
   Aranda, ML
   Caldareri, LJ
   Rosenstein, RE
   Repetto, EM
   Cymeryng, CB
AF Elisa Mercau, Maria
   Salvador Calanni, Juan
   Luis Aranda, Marcos
   Julia Caldareri, Lilian
   Estela Rosenstein, Ruth
   Martin Repetto, Esteban
   Beatriz Cymeryng, Cora
TI Melatonin prevents early pituitary dysfunction induced by sucrose-rich
   diets
SO JOURNAL OF PINEAL RESEARCH
LA English
DT Article
DE glucocorticoids; inflammation; melatonin; oxidative stress; pituitary;
   proopiomelanocortin; ACTH; sucrose rich diet
ID PROOPIOMELANOCORTIN GENE-EXPRESSION; METABOLIC SYNDROME;
   INSULIN-RESISTANCE; ADRENAL AXIS; NLRP3 INFLAMMASOME; CUSHINGS-SYNDROME;
   OXIDATIVE STRESS; KAPPA-B; RAT; ANTIOXIDANT
AB While physiological levels of glucocorticoids are required to ensure proper functions of the body, consistently high levels may engender several deleterious consequences. We have previously shown an increase in the activity of the hypothalamic-pituitary-adrenal (HPA) axis in rats fed sucrose-rich diets (SRD). The main goal of this study was to analyze the processes involved in the modulation of the pituitary production of ACTH by SRD, and to test melatonin as a possible therapeutic agent for the prevention of the HPA axis dysfunction. Male Wistar rats were fed standard chow and either SRD (30% sucrose in the drinking water) or plain water for three weeks. Melatonin was administered as subcutaneous pellets. Results showed that SRD treatment induced an increase in systemic ACTH and corticosterone levels and a decrease in melatonin levels. In the pituitary gland, we also detected an increase in the expression levels of proopiomelanocortin (POMC) that was accompanied by increased levels of: lipoperoxides, nitro-tyrosine modified proteins, catalase, heme oxygenase-1, interleukin-1 beta mRNA, and by an increase in the tissue number of inflammatory cells (F4/80 and Iba-1 positive cells). Melatonin treatment prevented all these systemic and pituitary changes as well as the increase in POMC expression induced by incubation of AtT-20 corticotrophs with conditioned media obtained from stimulated macrophages. In conclusion, stimulation of POMC/ACTH production in rats fed a SRD could involve the generation of oxidative stress and inflammation in the pituitary gland. Melatonin treatment prevented these effects and normalized the activity of the HPA axis.
C1 [Elisa Mercau, Maria; Salvador Calanni, Juan; Luis Aranda, Marcos; Julia Caldareri, Lilian; Estela Rosenstein, Ruth; Martin Repetto, Esteban; Beatriz Cymeryng, Cora] Univ Buenos Aires, Ctr Estudios Farmacol & Bot CEFYBO, CONICET, Fac Med, Buenos Aires, DF, Argentina.
   [Estela Rosenstein, Ruth; Beatriz Cymeryng, Cora] Univ Buenos Aires, Fac Med, Dept Bioquim Humana, Buenos Aires, DF, Argentina.
   [Martin Repetto, Esteban] Univ Buenos Aires, Fac Farm & Bioquim, Dept Bioquim Clin, Catedra Bioquim Clin 1, Buenos Aires, DF, Argentina.
   [Elisa Mercau, Maria] Yale Univ, Dept Immunobiol, New Haven, CT USA.
C3 Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET);
   University of Buenos Aires; University of Buenos Aires; University of
   Buenos Aires; Yale University
RP Cymeryng, CB (corresponding author), Univ Buenos Aires, Fac Med, Dept Bioquim Humana, Paraguari, Argentina.
EM cymeryng@fmed.uba
OI Calanni, Juan Salvador/0000-0002-0781-3165; Repetto,
   Esteban/0000-0001-6536-7370; Cymeryng, Cora/0000-0001-9586-3797; Mercau,
   Maria E/0000-0001-6971-8676; Aranda, Marcos/0000-0003-1891-3476
FU Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET)
   [PIP0257CO]; Fondo para la Investigacion Cientifica y Tecnologica
   [1008]; Sociedad Argentina de Diabetes (SAD); Universidad de Buenos
   Aires (UBA) [UBACYT 20020130100115BA]
FX Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET),
   Grant/Award Number: PIP0257CO; Fondo para la Investigacion Cientifica y
   Tecnologica, Grant/Award Number: PICT 2015 No 1008; Sociedad Argentina
   de Diabetes (SAD), Grant/Award Number: Ano 2016; Universidad de Buenos
   Aires (UBA), Grant/Award Number: UBACYT 20020130100115BA
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NR 89
TC 11
Z9 13
U1 1
U2 15
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0742-3098
EI 1600-079X
J9 J PINEAL RES
JI J. Pineal Res.
PD MAR
PY 2019
VL 66
IS 2
AR e12545
DI 10.1111/jpi.12545
PG 11
WC Endocrinology & Metabolism; Neurosciences; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Physiology
GA HM7SB
UT WOS:000459678400001
PM 30586198
OA Green Published
DA 2025-06-11
ER

PT J
AU Kelly, FJ
   Fussell, JC
AF Kelly, Frank J.
   Fussell, Julia C.
TI Role of oxidative stress in cardiovascular disease outcomes following
   exposure to ambient air pollution
SO FREE RADICAL BIOLOGY AND MEDICINE
LA English
DT Review
DE Ambient air pollution; Cardiovascular disease; Oxidative stress;
   Metabolic disease; Particulate matter; Gaseous pollutants
ID HEART-RATE-VARIABILITY; DIESEL EXHAUST PARTICULATE;
   INTERCELLULAR-ADHESION MOLECULE-1; ENDOTHELIAL PROGENITOR CELLS;
   LEFT-VENTRICULAR MASS; NITRIC-OXIDE; METABOLIC-SYNDROME; REACTIVE
   OXYGEN; GENE-EXPRESSION; ULTRAFINE PARTICLES
AB Exposure to ambient air pollution is associated with adverse cardiovascular outcomes. These are manifested through several, likely overlapping, pathways including at the functional level, endothelial dysfunction, atherosclerosis, pro-coagulation and alterations in autonomic nervous system balance and blood pressure. At numerous points within each of these pathways, there is potential for cellular oxidative imbalances to occur. The current review examines epidemiological, occupational and controlled exposure studies and research employing healthy and diseased animal models, isolated organs and cell cultures in assessing the importance of the prooxidant potential of air pollution in the development of cardiovascular disease outcomes. The collective body of data provides evidence that oxidative stress (OS) is not only central to eliciting specific cardiac endpoints, but is also implicated in modulating the risk of succumbing to cardiovascular disease, sensitivity to ischemia/reperfusion injury and the onset and progression of metabolic disease following ambient pollution exposure. To add to this large research effort conducted to date, further work is required to provide greater insight into areas such as (a) whether an oxidative imbalance triggers and/or worsens the effect and/or is representative of the consequence of disease progression, (b) OS pathways and cardiac outcomes caused by individual pollutants within air pollution mixtures, or as a consequence of inter-pollutant interactions and (c) potential protection provided by nutritional supplements and/or pharmacological agents with antioxidant properties, in susceptible populations residing in polluted urban cities.
C1 [Kelly, Frank J.; Fussell, Julia C.] Kings Coll London, NIHR Hlth Protect Res Unit Hlth Impact Environm H, Facil Life Sci & Med, 150 Stamford St, London SE1 9NH, England.
C3 University of London; King's College London
RP Kelly, FJ (corresponding author), Kings Coll London, NIHR Hlth Protect Res Unit Hlth Impact Environm H, Facil Life Sci & Med, 150 Stamford St, London SE1 9NH, England.
EM frank.kelly@kcl.ac.uk
RI Kelly, Frank/C-6125-2009
FU National Institute for Health Research Health Protection Research Unit
   (NIHR HPRU) in Health Impacts of Environmental Hazards at King's College
   London; Public Health England (PHE) [HPRU-2012-10030]; MRC
   [MR/L01341X/1] Funding Source: UKRI
FX This work was funded by the National Institute for Health Research
   Health Protection Research Unit (NIHR HPRU) in Health Impacts of
   Environmental Hazards at King's College London in partnership with
   Public Health England (PHE) (HPRU-2012-10030). The views expressed are
   those of the authors and not necessarily those of the NHS, the NIHR, the
   Department of Health or Public Health England
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NR 156
TC 115
Z9 122
U1 2
U2 46
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0891-5849
EI 1873-4596
J9 FREE RADICAL BIO MED
JI Free Radic. Biol. Med.
PD SEP
PY 2017
VL 110
BP 345
EP 367
DI 10.1016/j.freeradbiomed.2017.06.019
PG 23
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA FB3NK
UT WOS:000406049200032
PM 28669628
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Bonner, WIA
   Weiler, R
   Orisatoki, R
   Lu, XY
   Andkhoie, M
   Ramsay, D
   Yaghoubi, M
   Steeves, M
   Szafron, M
   Farag, M
AF Bonner, William Ian Andrew
   Weiler, Robert
   Orisatoki, Rotimi
   Lu, Xinya
   Andkhoie, Mustafa
   Ramsay, Dana
   Yaghoubi, Mohsen
   Steeves, Megan
   Szafron, Michael
   Farag, Marwa
TI Determinants of self-perceived health for Canadians aged 40 and older
   and policy implications
SO INTERNATIONAL JOURNAL FOR EQUITY IN HEALTH
LA English
DT Article
DE Self-perceived health; Chronic disease; Stress; Social determinants of
   health; Older adults; Healthy public policies
ID RATED HEALTH; PSYCHOLOGICAL DISTRESS; PSYCHOSOCIAL STRESS; METABOLIC
   SYNDROME; CHRONIC DISEASE; HEART-DISEASE; RISK-FACTOR; MORTALITY;
   ADULTS; TRAJECTORIES
AB Background: Perceived health status indicates people's overall perception of their health, including both physical and psychological dimensions. The aim of this study was to examine the determinants of self-perceived health for Canadians aged 40 and older using data from the Canadian Community Health Survey (2010).
   Methods: Multiple logistic regression models were employed to identify factors associated with self-perceived health in two age groups: Adults aged 65+ and Adults aged 40-64.
   Results: We found that higher income was significantly associated with better health status while chronic conditions and stress were associated with worse health status. In the 40-64 and 65+ age groups, individuals in the highest income bracket were 4.65 and 1.94 times, respectively, more likely to report better health than individuals in the lowest income bracket. The difference in the level of income associated health inequities between the two age groups point to the need for understanding the reasons behind lower inequities among seniors and how much the social protections provided by the Canadian government to seniors contribute to lowering inequities.
   Conclusions: Though Canada has a national public health insurance system providing coverage to all Canadians, health inequities associated with income persist providing further evidence of the importance of the social determinants of health. Examining the extent of these inequities and what factors influence them helps direct policy attention. In addition to documenting inequities, this paper discusses policy options for reducing the identified inequities.
C1 [Bonner, William Ian Andrew; Weiler, Robert; Orisatoki, Rotimi; Lu, Xinya; Andkhoie, Mustafa; Ramsay, Dana; Yaghoubi, Mohsen; Steeves, Megan; Szafron, Michael; Farag, Marwa] Univ Saskatchewan, Sch Publ Hlth, 104 Clin Pl,Room 3334, Saskatoon, SK S7N 5E3, Canada.
C3 University of Saskatchewan
RP Farag, M (corresponding author), Univ Saskatchewan, Sch Publ Hlth, 104 Clin Pl,Room 3334, Saskatoon, SK S7N 5E3, Canada.
EM marwa.farag@usask.ca
RI Yaghoubi, Mohsen/T-6630-2017; Andkhoie, Mustafa/ABQ-6668-2022
OI Andkhoie, Mustafa/0000-0002-6600-0797; Yaghoubi,
   Mohsen/0000-0002-6912-7267
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NR 53
TC 44
Z9 50
U1 0
U2 3
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1475-9276
J9 INT J EQUITY HEALTH
JI Int. J. Equity Health
PD JUN 6
PY 2017
VL 16
AR 94
DI 10.1186/s12939-017-0595-x
PG 9
WC Public, Environmental & Occupational Health
WE Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA EY4TZ
UT WOS:000403971700001
PM 28587654
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Alatalo, P
   Koivisto, H
   Kultti, J
   Bloigu, R
   Niemelä, O
AF Alatalo, Paivikki
   Koivisto, Heidi
   Kultti, Johanna
   Bloigu, Risto
   Niemela, Onni
TI Evaluation of reference intervals for biomarkers sensitive to alcohol
   consumption, excess body weight and oxidative stress
SO SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION
LA English
DT Article
DE Alanine aminotransferase; aspartate aminotransferase; body mass index;
   ethanol; gamma-glutamyltransferase; normal limit; overweight; uric acid
ID COMMON REFERENCE INTERVALS; NONALCOHOLIC STEATOHEPATITIS NASH;
   GAMMA-GLUTAMYL-TRANSFERASE; LIVER-CIRRHOSIS MORTALITY; AMINOTRANSFERASE
   LEVELS; CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; MASS INDEX;
   URIC-ACID; RISK
AB Background. Unexplained liver enzyme activities are often found in health screening programs and constitute an increasingly common cause for referral to specialized clinics. Recent studies have indicated that both excess body weight and alcohol consumption may lead to metabolic aberrations which are readily reflected in the activities of liver enzymes in circulation. Materials and methods. We compared various laboratory markers and their upper normal limits in relation to information on alcohol consumption and BMI in a large population of apparently healthy individuals collected from Nordic countries. Results. Based on the data obtained from normal weight abstainers (BMI 19-25 kg/m<SU2</SU) the upper normal limits in men should be 50 U/L for ALT, and 45 U/L (< 40 years) and 70 U/L (>= 40 years) for GGT, while the current recommendations are 70 U/L, 80 U/L, and 115 U/L, respectively. Already in comparisons between normal weight abstainers and corresponding moderate drinkers notable impacts (+14% - +74%) on upper limits for these analytes were seen, which further grew when adiposity occurred together with alcohol drinking (+75% - +186%, BMI >= 27 kg/m<SU2</SU). In addition to liver enzymes, similar changes were also found for uric acid. Conclusions. Alcohol consumption and excess body weight even in apparently healthy individuals have a significant influence on liver enzyme activities, which may be due to a cumulative oxidative stress burden. The metabolic changes induced by adiposity or ethanol intake should be considered in the definition of normal ranges for all laboratory parameters sensitive to oxidative stress.
C1 [Alatalo, Paivikki; Koivisto, Heidi; Kultti, Johanna; Niemela, Onni] Seinajoki Cent Hosp, Med Res Unit, FIN-60220 Seinajoki, Finland.
   [Alatalo, Paivikki; Koivisto, Heidi; Kultti, Johanna; Niemela, Onni] Seinajoki Cent Hosp, Dept Lab Med, FIN-60220 Seinajoki, Finland.
   Univ Tampere, FIN-33101 Tampere, Finland.
   [Bloigu, Risto] Univ Oulu, Med Informat Grp, Oulu, Finland.
C3 Seinajoki Central Hospital; Seinajoki Central Hospital; Tampere
   University; University of Oulu
RP Alatalo, P (corresponding author), Seinajoki Cent Hosp, Med Res Unit, FIN-60220 Seinajoki, Finland.
EM paivikki.alatalo@epshp.fi
RI Kangastupa, Päivikki/JZZ-0468-2024
OI Kangastupa, Paivikki/0000-0003-0695-6073
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   [No title captured]
NR 42
TC 11
Z9 11
U1 0
U2 2
PU TAYLOR & FRANCIS AS
PI OSLO
PA KARL JOHANS GATE 5, NO-0154 OSLO, NORWAY
SN 0036-5513
J9 SCAND J CLIN LAB INV
JI Scand. J. Clin. Lab. Invest.
PY 2010
VL 70
IS 2
BP 104
EP 111
DI 10.3109/00365510903548818
PG 8
WC Medical Laboratory Technology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology; Research & Experimental Medicine
GA 571GW
UT WOS:000275740900008
PM 20073674
DA 2025-06-11
ER

PT J
AU Lastra, G
   Manrique, C
   Sowers, JR
AF Lastra, Guido
   Manrique, Camila
   Sowers, James R.
TI Obesity, cardiometabolic syndrome, and chronic kidney disease: The
   weight of the evidence
SO ADVANCES IN CHRONIC KIDNEY DISEASE
LA English
DT Article
DE obesity; cardiometabolic syndrome; insulin resistance; compensatory
   hyperinsulinemia; oxidative stress; renin-angiotensin system;
   microalbuminuria; matrix fibrosis; chronic kidney disease
ID RENIN-ANGIOTENSIN SYSTEM; URINARY ALBUMIN EXCRETION; 3RD
   NATIONAL-HEALTH; STAGE RENAL-DISEASE; BODY-MASS INDEX; GROWTH-FACTOR-I;
   FACTOR-KAPPA-B; METABOLIC SYNDROME; INSULIN-RESISTANCE; BLOOD-PRESSURE
AB The epidemic of obesity experienced in both industrialized and nonindustrialized countries largely accounts for the increase in the prevalence of the cardiometabolic syndrome (CMS). Obesity and the CMS significantly increase the risk for cardiovascular disease (CVD) and chronic kidney disease (CKD). Multiple abnormalities that can lead to kidney injury have been identified in overweight and obese people, including insulin resistance, compensatory hyperinsulinemia, inappropriate activation of the renin-angiotensin-aldosterone system and increased oxidative stress, endoplasmic reticulum stress, coagulability, and impaired fibrinolysis. The combined effects of these conditions induce in the kidneys impaired pressure natriuresis, glomerular hypertension, endothelial dysfunction, and vasoconstriction, as well as matrix proliferation and expansion. Among the consequences are microalbuminuria, now known to be a surrogate of diffuse endothelial dysfunction as well as a predictor of CVD, and CKD. Diet and regular physical activity are the cornerstones of weight management, and they add to currently available pharmacologic agents and bariatric surgery. The understanding of the pathophysiology of obesity/CMS helps to explain the benefits of agents that improve insulin sensitivity, control inflammation, and block the renin-angiotensin-aldosterone system. The increasing prevalence of obesity and CMS contribute to the growing frequency of CKD and demands the development of multifactorial strategies directed at identifying people at risk, as well as preventing excessive weight gain and its deleterious consequences. (c) 2006 by the National Kidney Foundation, Inc.
C1 Harry S Truman Mem Vet Hosp, Columbia, MO 65201 USA.
C3 US Department of Veterans Affairs; Veterans Health Administration (VHA);
   Harry S. Truman Memorial Veterans' Hospital
RP Sowers, JR (corresponding author), Univ Missouri, Dept Internal Med, 800 Hosp Dr,Room F035, Columbia, MO 65201 USA.
EM sowersj@health.missouri.edu
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NR 71
TC 49
Z9 54
U1 0
U2 4
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 1548-5595
EI 1548-5609
J9 ADV CHRONIC KIDNEY D
JI Adv. Chronic Kidney Dis.
PD OCT
PY 2006
VL 13
IS 4
BP 365
EP 373
DI 10.1053/j.ackd.2006.07.011
PG 9
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 096SH
UT WOS:000241396600006
PM 17045222
OA Bronze
DA 2025-06-11
ER

PT J
AU Kim, J
   Lee, JY
   Kim, CY
AF Kim, Juhae
   Lee, Joo-Yeon
   Kim, Choon Young
TI Allium macrostemon whole extract ameliorates obesity-induced
   inflammation and endoplasmic reticulum stress in adipose tissue of
   high-fat diet-fed C57BL/6N mice
SO FOOD & NUTRITION RESEARCH
LA English
DT Article
DE Allium macrostemon extract; adipose tissue; inflammation; endoplasmic
   reticulum stress
ID ACID SYNTHASE; HEALTH; EXPRESSION; VEGETABLES; RESISTANCE; ADIPOCYTE;
   PLASMA; GENES
AB Background: Obesity is a major risk factor for metabolic syndrome and a serious health concern worldwide. Various strategies exist to treat and prevent obesity, including dietary approaches using bioactive ingredients from natural sources.Objective: This study aimed to investigate the anti-obesity effect of whole-plant Allium macrostemon (also called as long-stamen chive) extract (AME) as a potential new functional food.Design: C57BL/6N mice were divided into three groups and fed either a control diet (CD), high-fat diet (HFD), or HFD with AME treatment (200 mg/kg BW daily) for 9 weeks. The mice in the CD and HFD groups were treated with vehicle control. Results: AME supplementation reduced HFD-induced body weight gain, fat mass, and adipocyte size. AME suppressed peroxisome proliferator-activated receptor gamma and fatty acid synthase mRNA expression, indicating reduced adipogenesis and lipogenesis in adipose tissue. In addition, AME lowered inflammation in adipose tissue, as demonstrated by the lower number of crown-like structures, mRNA, and/or protein expression of macrophage filtration markers, as well as pro-inflammatory cytokines, including F4/80 and IL-6. Endoplasmic reticulum stress was also alleviated by AME administration in adipose tissue. Several phenolic acids known to have anti-obesity effects, including ellagic acid, protocatechuic acid, and catechin, have been identified in AME.Conclusion: By suppressing adipose tissue expansion and inflammation, AME is a potential functional food for the prevention and/or treatment of obesity and its complications.
C1 [Kim, Juhae; Lee, Joo-Yeon; Kim, Choon Young] Yeungnam Univ, Res Inst Human Ecol, Gyongsan 38541, Gyeongbuk, South Korea.
   [Lee, Joo-Yeon; Kim, Choon Young] Yeungnam Univ, Dept Food & Nutr, Gyongsan 38541, Gyeongbuk, South Korea.
C3 Yeungnam University; Yeungnam University
RP Kim, CY (corresponding author), Yeungnam Univ, Dept Food & Nutr, Gyongsan 38541, Gyeongbuk, South Korea.
EM cykim@yu.ac.kr
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TC 8
Z9 8
U1 2
U2 10
PU SWEDISH NUTRITION FOUNDATION-SNF
PI LUND
PA IDEON SCIENCE PARK, BESOK SCHEELEV 17 BETA 5, 3V, LUND, 223 70, SWEDEN
SN 1654-6628
EI 1654-661X
J9 FOOD NUTR RES
JI Food Nutr. Res.
PD MAY 18
PY 2023
VL 67
BP 1
EP 13
DI 10.29219/fnr.v67.9256
PG 13
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA H4ZG6
UT WOS:000996056100001
PM 37223261
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Zhang, JL
   Wu, JJ
   Liu, FG
   Tong, LJ
   Chen, Z
   Chen, JL
   He, HY
   Xu, R
   Ma, YY
   Huang, C
AF Zhang, Jinlin
   Wu, Jingjing
   Liu, Fengguo
   Tong, Lijuan
   Chen, Zhuo
   Chen, Jinliang
   He, Haiyan
   Xu, Rong
   Ma, Yaoying
   Huang, Chao
TI Neuroprotective effects of anthocyanins and its major component
   cyanidin-3-O-glucoside (C3G) in the central nervous system: An outlined
   review
SO EUROPEAN JOURNAL OF PHARMACOLOGY
LA English
DT Review
DE Anthocyanins; Oxidative stress; Neuroinflammation; Central nervous
   system; C3G
ID ACID-INDUCED EXCITOTOXICITY; INDUCED OXIDATIVE STRESS;
   MONOAMINE-OXIDASE-B; NITRIC-OXIDE; CARBON-MONOXIDE; IN-VITRO;
   PARKINSONS-DISEASE; SIGNALING PATHWAY; HEME OXYGENASE-1; MOUSE MODEL
AB Anthocyanins, a class of water soluble flavonoids extracted from plants like berries and soybean seed, have been shown to display obvious anti-oxidative, anti-inflammatory, and anti-apoptotic activities. They are recommended as a supplementation for prevention and/or treatment of disorders ranging from cardiovascular disease, metabolic syndrome, and cancer. In the central nervous system (CNS), anthocyanins and its major component cyanidin-3-O-glucoside (C3G) have been reported to produce preventive and/or therapeutic activities in a wide range of disorders, such as cerebral ischemia, Alzheimer's disease, Parkinson's disease, multiple sclerosis, and glioblastoma. Both anthocyanins and C3G can also affect some important processes in aging, including neuronal apoptosis and death as well as learning and memory impairment. Further, the anthocyanins and C3G have been shown to prevent neuro-toxicities induced by different toxic factors, such as lipopolysaccharide, hydrogen peroxide, ethanol, kainic acid, acrolein, glutamate, and scopolamine. Mechanistic studies have shown that inhibition of oxidative stress and neuroinflammation are two critical mechanisms by which anthocyanins and C3G produce protective effects in CNS disorder prevention and/or treatment. Other mechanisms, including suppression of c-Jun N-terminal kinase (JNK) activation, amelioration of cellular degeneration, activation of the brain-derived neurotrophic factor (BDNF) signaling, and restoration of Ca2+ and Zn2+ homeostasis, may also mediate the neuroprotective effects of anthocyanins and C3G. In this review, we summarize the pharmacological effects of anthocyanins and C3G in CNS disorders as well as their possible mechanisms, aiming to get a clear insight into the role of anthocyanins in the CNS.
C1 [Zhang, Jinlin] Nantong Univ, Affiliated Canc Hosp, Dept Pharm, 30 Tongyang North Rd, Nantong 226361, Jiangsu, Peoples R China.
   [Tong, Lijuan; Ma, Yaoying; Huang, Chao] Nantong Univ, Sch Pharm, Dept Pharmacol, 19 Qixiu Rd, Nantong 226001, Jiangsu, Peoples R China.
   [Wu, Jingjing] Shanghai Jiao Tong Univ, Sch Med, Suzhou Kowloon Hosp, Dept Cardiol, 118 Wansheng St, Suzhou 215021, Jiangsu, Peoples R China.
   [Liu, Fengguo] Danyang Peoples Hosp, Dept Neurol, Danyang 212300, Jiangsu, Peoples R China.
   [Chen, Zhuo] Nantong Univ, Affiliated Hosp 2, Nantong Peoples Hosp 1, Invas Technol Dept, 6 North Rd Haier Xiang, Nantong 226001, Jiangsu, Peoples R China.
   [Chen, Jinliang; He, Haiyan] Nantong Univ, Affiliated Hosp 2, Dept Resp Med, 20 Xisi Rd, Nantong 226001, Jiangsu, Peoples R China.
   [Xu, Rong] Nantong Hlth Coll Jiangsu Prov, Dept Pharm & Med Technol, 288 Zhenxing East Rd, Nantong 226009, Jiangsu, Peoples R China.
C3 Nantong University; Nantong University; Shanghai Jiao Tong University;
   Nantong University; Nantong University
RP Ma, YY; Huang, C (corresponding author), Nantong Univ, Sch Pharm, Dept Pharmacol, 19 Qixiu Rd, Nantong 226001, Jiangsu, Peoples R China.
EM yaoyingpitt@gmail.com; huachao@ntu.edu.cn
RI Huang, Chao/L-1445-2019; Xu, Rong/W-1112-2018
FU Natural Science Foundation of China [81571323, 81771467, 81701286,
   31771172]; Natural Science Foundation of Jiangsu Province [BK20180267];
   Cultivation Scientific Research Project of Suzhou Kowloon Hospital of
   Shanghai Jiaotong University School of Medicine [JL201804]; Science and
   Technology Project of Nantong City [MS12018078, JC2018057]; Six Talent
   Peaks Project in Jiangsu Province [SWYY-071]
FX We cordially acknowledge the Natural Science Foundation of China (No.
   81571323, 81771467, 81701286, and 31771172), the Natural Science
   Foundation of Jiangsu Province (BK20180267), the Cultivation Scientific
   Research Project of Suzhou Kowloon Hospital of Shanghai Jiaotong
   University School of Medicine (JL201804), the Science and Technology
   Project of Nantong City (MS12018078 and JC2018057), and the Six Talent
   Peaks Project in Jiangsu Province (SWYY-071). We also apologize to all
   the colleagues whose valuable work could not be cited.
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NR 138
TC 105
Z9 110
U1 6
U2 109
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0014-2999
EI 1879-0712
J9 EUR J PHARMACOL
JI Eur. J. Pharmacol.
PD SEP 5
PY 2019
VL 858
AR 172500
DI 10.1016/j.ejphar.2019.172500
PG 10
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA IM0SI
UT WOS:000477699100031
PM 31238064
DA 2025-06-11
ER

PT J
AU Jha, D
   Mazumder, PM
AF Jha, Dhruv
   Mazumder, Papiya Mitra
TI High fat diet administration leads to the mitochondrial dysfunction and
   selectively alters the expression of class 1 GLUT protein in mice
SO MOLECULAR BIOLOGY REPORTS
LA English
DT Article
DE High fat diet; GLUT 1-4; Mitochondrial dysfunction; LDH; Liver; Skeletal
   muscles; White adipose tissue
ID GLUCOSE TRANSPORTERS GLUT; INSULIN-RESISTANCE; MONOCARBOXYLATE
   TRANSPORTERS; ENDOPLASMIC-RETICULUM; HEPATIC EXPRESSION; ADIPOSE-TISSUE;
   TNF-ALPHA; INFLAMMATION; HYPOXIA; DISEASE
AB Metabolic syndrome is an agglomeration of disorders including obesity, diabetes and cardiovascular diseases and characterized as chronic mild inflammation which elevates the circulatory inflammatory markers. This could be due to mitochondrial dysfunction, oxidative stress and hypoxia as a consequence of high fat diet (HFD) intake. The present study focuses on the effects of HFD on lactate and mitochondrial metabolism as well as tissue dependent changes in glucose transporter (GLUT) expression in liver, skeletal muscles and adipose tissue of mouse. Lactate dehydrogenase (LDH) and mitochondrial dysfunction established the link between the occurrences of metabolic stress due to HFD. In this work, it was observed that chronic HFD administration aggravated the metabolic alterations by causing reduced ATP production, imbalanced oxidative stress and altered class 1 GLUTs expression. Chronic HFD significantly reduced (p<0.001) the superoxide dismutase (SOD), catalase (CAT) activities alongside elevated liver injury markers AST and ALT. This in turn causes decreased ATP/ADP ratio, mitochondrial dysfunction and exacerbated LDH levels. This imbalance further led to altered GLUT expression in hepatic cells, adipose tissue and skeletal muscles. HFD significantly (p<0.001) upregulated the GLUT 1 and 3 expressions while significant downregulated (p<0.001) GLUT 2 and 4 expression in liver, skeletal muscles and white adipose tissue. These results revealed the link between class 1 GLUTs, mitochondrial dysfunction and HFD-induced metabolic disorder. It can be concluded that HFD impacts mitochondrial metabolism and reprograms tissue-dependent glucose transporter.
C1 [Jha, Dhruv; Mazumder, Papiya Mitra] Birla Inst Technol, Dept Pharmaceut Sci & Technol, Ranchi, Jharkhand, India.
C3 Birla Institute of Technology Mesra
RP Jha, D (corresponding author), Birla Inst Technol, Dept Pharmaceut Sci & Technol, Ranchi, Jharkhand, India.
EM dhruvjha89@gmail.com; pmitramazumder@bitmesra.ac.in
RI Mazumder, Papiya/V-7314-2019
OI Mazumder, Papiya Mitra/0000-0002-3009-6248
FU UGC
FX The authors would like to acknowledge Ms Parul Gupta and Mr Santosh
   Prajapati for technical help. Authors also acknowledge the Department of
   Pharmaceutical Sciences and Technology, Birla Institute of Technology
   for providing the facilities. Authors are grateful to UGC for providing
   financial assistance.
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NR 57
TC 25
Z9 28
U1 2
U2 12
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0301-4851
EI 1573-4978
J9 MOL BIOL REP
JI Mol. Biol. Rep.
PD APR
PY 2019
VL 46
IS 2
BP 1727
EP 1736
DI 10.1007/s11033-019-04623-y
PG 10
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA HS6QP
UT WOS:000463996700021
PM 30725350
DA 2025-06-11
ER

PT J
AU Zhang, LG
   Guo, LM
   Zhang, MY
   Niu, N
   Wang, LJ
AF Zhang, Ligong
   Guo, Leiming
   Zhang, Mengyuan
   Niu, Na
   Wang, Lijun
TI The involvement of lectin-like oxidized low density lipoprotein
   receptor-1 and p38MAPK in early diabetic nephropathy
SO INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
LA English
DT Article
DE Diabetic nephropathy; p38MAPK; lectin-like oxidized low density
   lipoprotein; oxidative stress; SB203580
ID NITRIC-OXIDE SYNTHASE; LOX-1 EXPRESSION; OXIDATIVE STRESS; METABOLIC
   SYNDROME; P38 MAPK; CELLS; RATS; POLYNEUROPATHY; MECHANISM; PATHWAY
AB Backgrounds: The present study aimed to investigate the effects of Lectin-like Oxidized Low Density lipoprotein receptor-1 (LOX-1) as well as the interaction of LOX-1 and p38MAPK pathway in early diabetic nephropathy (DN). Methods: 30 male rats were divided into 3 groups: normal control (NC), diabetes mellitus (DM) and SB203580 (p38MAPK inhibitor) treatment (SB203580) groups. Diabetic rats were induced by Streptozotocin-injection. After the onset of diabetes, rats in SB203580 group were administrated by SB203580. Six weeks afterwards, blood glucose (BG) and serum oxLDL was evaluated. Renal function markers such as serum creatinine (sCr), blood urea nitrogen (BUN), creatinine clearance rate (cCr) and urinary albumin excretion rate (UAER) were measured. Meantime, renal glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) were examined as parameters of oxidative stress. The levels of phosphorylated-p38 MAPK (p-p38MAPK) in renal cortex were evaluated by western blot and immunohistochemistry, the renal expression levels of LOX-1 protein and mRNA also were detected by western blot or real-time PCR. Results: Compared to NC group, the levels of BG, oxLDL, BUN, sCr, cCr and UAER were increased in DM group, while the activities of renal GSH-Px and SOD were significantly decreased. Meanwhile, LOX-1 expression- and p-p38MAPK levels were also upregulated in diabetic rats. However, the inactivation of p38 MAPK alleviated the upregulation of LOX-1 expression induced by diabetes. Meantime, all the parameters to evaluate renal injury were significantly attenuated by the administration of SB203580. Conclusions: The upregulation of LOX-1 by p38MAPK are important to the pathogenesis of DN.
C1 [Zhang, Ligong; Zhang, Mengyuan] Shandong Univ, Shandong Prov Hosp, Dept Anesthesia, Jinan 250021, Peoples R China.
   [Guo, Leiming; Niu, Na; Wang, Lijun] Shandong Univ, Shandong Prov Hosp, Dept Pediat, Jinan 250021, Peoples R China.
C3 Shandong First Medical University & Shandong Academy of Medical
   Sciences; Shandong University; Shandong First Medical University &
   Shandong Academy of Medical Sciences; Shandong University
RP Wang, LJ (corresponding author), Shandong Univ, Shandong Prov Hosp, Dept Pediat, Jinan 250021, Peoples R China.
EM wangljcocoa@126.com
RI Niu, Na/A-2915-2016
FU Excellent Adult and Young Scientist Science Foundation of Shandong
   Province [BS2010YY056]; Youth Foundation of Shandong Natural Science
   Foundation [2014ZRB14078]
FX This research work was supported by Excellent Adult and Young Scientist
   Science Foundation of Shandong Province (BS2010YY056) and Youth
   Foundation of Shandong Natural Science Foundation (2014ZRB14078).
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NR 31
TC 0
Z9 0
U1 0
U2 2
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 1940-5901
J9 INT J CLIN EXP MED
JI Int. J. Clin. Exp. Med.
PY 2016
VL 9
IS 2
BP 2391
EP 2398
PG 8
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA DK1EL
UT WOS:000374655200208
DA 2025-06-11
ER

PT J
AU Victorino, VJ
   Mencalha, AL
   Panis, C
AF Victorino, Vanessa Jacob
   Mencalha, Andre Luiz
   Panis, Carolina
TI Post-translational modifications disclose a dual role for redox stress
   in cardiovascular pathophysiology
SO LIFE SCIENCES
LA English
DT Review
DE Cardiac disease; Post-translational modifications; Oxidative stress;
   Cardioprotection
ID GLYCATION END-PRODUCTS; PROTEIN S-GLUTATHIONYLATION; OXIDATIVE STRESS;
   NITRIC-OXIDE; LIPID-PEROXIDATION; MITOCHONDRIAL BIOGENESIS;
   N-ACETYLGLUCOSAMINE; METABOLIC SYNDROME; HEART-FAILURE; CELL-DEATH
AB Although some of the redox changes that occur in biological components may result in deleterious events, this process has recently been tackled as a modulatory event. Advances in our understanding regarding the role of some oxidative/nitrosative reactions revealed that proteins can be structurally and functionally modified by chemical reactions, an epigenetic event known as post-translational modification (PTM). PTMs can function as an "on-off switch" for signaling cascades, and are dependent on the specific generation of redox components such as reactive oxygen species (ROS) and nitric oxide (NO). NO-driven modifications regulate a wide range of cellular processes and have been highlighted as an epigenetic event that protects proteins from proteolytic degradation. On the other hand, ROS-driven modifications are implicated in cell damage in a number of pathological conditions, especially in the cardiovascular system. Therefore, while mitochondrial uncoupling yields the massive production of ROS in the heart, some cellular redox-sensitive pathways trigger PTMs that may play a cardioprotective role. In this review, we present an overview of the oxidative/nitrosative milieu in cardiac pathologies and address the role of the main redox-driven FTMs as epigenetic events in cardioprotection, as well as its regulatory function in cardiomyocyte signaling. Improved understanding of the role of these FTMs in cardiovascular disease can help direct some approaches for future clinical research regarding health risk assessment, as well as inform strategies for disease treatment and prevention. (C) 2014 Elsevier Inc. All rights reserved.
C1 [Victorino, Vanessa Jacob] Univ Sao Paulo, Fac Med, Sao Paulo, Brazil.
   [Mencalha, Andre Luiz] Univ Estado Rio De Janeiro, Programa Posgrad Biociencias, Rio De Janeiro, Brazil.
   [Panis, Carolina] State Univ West Parana, UNIOESTE, Lab Inflammatory Mediators, Toledo, Parana, Brazil.
C3 Universidade de Sao Paulo; Universidade do Estado do Rio de Janeiro;
   Universidade Estadual do Oeste do Parana
RP Panis, C (corresponding author), Univ Estadual Oeste Parana UNIOESTE, Lab Inflammatory Mediators, Colegiado Med, CCSA, Rua Maringa 1200, BR-85605010 Francisco Beltrao, Parana, Brazil.
EM carolpanis@hotmail.com
RI Victorino, Vanessa/A-5039-2014; Mencalha, Andre/Y-2522-2019; PANIS,
   CAROLINA/O-1490-2015
OI Jacob Victorino, Vanessa/0000-0001-9339-2653; Mencalha, Andre
   Luiz/0000-0003-3229-8094; PANIS, CAROLINA/0000-0002-0104-4369
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NR 98
TC 24
Z9 25
U1 0
U2 16
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0024-3205
EI 1879-0631
J9 LIFE SCI
JI Life Sci.
PD MAY 15
PY 2015
VL 129
SI SI
BP 42
EP 47
DI 10.1016/j.lfs.2014.11.008
PG 6
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA CH4LE
UT WOS:000354004200008
PM 25433127
DA 2025-06-11
ER

PT J
AU Ketonen, J
   Shi, J
   Martonen, E
   Mervaala, E
AF Ketonen, Juha
   Shi, Jin
   Martonen, Essi
   Mervaala, Eero
TI Periadventitial Adipose Tissue Promotes Endothelial Dysfunction via
   Oxidative Stress in Diet-Induced Obese C57BI/6 Mice
SO CIRCULATION JOURNAL
LA English
DT Article
DE Endothelial dysfunction; Obesity; Perivascular fat; Vasoconstriction
ID NITRIC-OXIDE SYNTHASE; HYDROGEN-PEROXIDE; VASCULAR FUNCTION;
   SMOOTH-MUSCLE; CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; SUPEROXIDE
   ANION; BLOOD-PRESSURE; EXPRESSION; FAT
AB Background: Biological substances derived from perivascular fat modulate vascular tone, thus alterations in periadventitial adipose tissue (PVAT) may aggravate endothelial dysfunction in obesity.
   Methods and Results: Male C57BI/6 mice were fed either a high-fat diet or standard laboratory chow for 8 months. Vascular responses were studied in organ bath chambers from abdominal aortic ring preparations in the absence or presence of PVAT. The amount of PVAT as well as the cross-sectional area of adipocytes were increased in obese mice. In the presence of PVAT, obese aortas displayed impaired endothelium-dependent vasodilation whereas endothelium-independent vasodilatation was unaltered. Endothelium-dependent vasodilatation was restored after removal of PVAT and after reducing superoxide and hydrogen peroxide formation in the vascular wall by Tiron or polyethylene-glycol-catalase, respectively. PVAT from obese mice showed increased formation of hydrogen peroxide and superoxide. The PVAT-derived oxidative stress was abolished by pretreatment with the reduced nicotinamide adenine dinucleotide phosphate (NADPH)-oxidase inhibitor, apocynin. The anti-contractile function of PVAT found in lean mice was completely abolished in obese mice, but partially restored after pretreatment with Tiron. The mRNA expressions of monocyte chemotactic protein-1, leptin and NADPH oxidase were markedly higher in the PVAT of obese than lean mice.
   Conclusions: PVAT promotes endothelial dysfunction in diet-induced obese C57BI/6 mice via mechanisms that are linked to increased NADPH oxidase-derived oxidative stress and increased production of pro-inflammatory cytokines. (Circ J 2010; 74: 1479 1487)
C1 [Mervaala, Eero] Univ Helsinki, Inst Biomed, Biomedicum Helsinki, FI-00014 Helsinki, Finland.
   [Ketonen, Juha] Univ Eastern Finland, Sch Pharm, Kuopio, Finland.
C3 University of Helsinki; University of Eastern Finland
RP Mervaala, E (corresponding author), Univ Helsinki, Inst Biomed, Biomedicum Helsinki, POB 63,Haartmaninkatu 8, FI-00014 Helsinki, Finland.
EM eero.mervaala@helsinki.fi
FU Academy of Finland; Sigrid Juselius Foundation; Aili and Aarne Turunen
   Foundation; Finnish Cultural Foundation
FX This study was supported by grants from the Academy of Finland,
   University's Research Funds, the Sigrid Juselius Foundation, Aili and
   Aarne Turunen Foundation and the Finnish Cultural Foundation. We are
   grateful to Ms Nada Bechara-Hirvonen, Ms Anneli von Behr and Ms Sari
   Laakkonen for expert technical assistance. We also thank Mr Ewen
   McDonald for helpful comments on language.
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NR 39
TC 158
Z9 177
U1 0
U2 11
PU JAPANESE CIRCULATION SOC
PI TOYKO
PA 18TH FLOOR IMPERIAL HOTEL TOWER, 1-1-1 UCHISAIWAI-CHO CHIYODA-KU, TOYKO,
   100-0011, JAPAN
SN 1346-9843
EI 1347-4820
J9 CIRC J
JI Circ. J.
PD JUL
PY 2010
VL 74
IS 7
BP 1479
EP 1487
DI 10.1253/circj.CJ-09-0661
PG 9
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 618OW
UT WOS:000279366500035
PM 20526041
OA Bronze
DA 2025-06-11
ER

PT J
AU El-Magd, NFA
   El-Mesery, M
   El-Karef, A
   El-Shishtawy, MM
AF El-Magd, Nada F. Abo
   El-Mesery, Mohamed
   El-Karef, Amro
   El-Shishtawy, Mamdouh M.
TI Glycyrrhizin ameliorates high fat diet-induced obesity in rats by
   activating NrF2 pathway
SO LIFE SCIENCES
LA English
DT Article
DE Gluconeogenic enzymes; Glycyrrhizin; Insulin receptor; Insulin
   resistance; Malondialdehyde; Nuclear factor erythroid-2 related
   factor-2; Obesity
ID INDUCED METABOLIC SYNDROME; INSULIN-RESISTANCE; OXIDATIVE STRESS; ACID;
   MODEL; MICE; EXPRESSION; DISEASE; HYPERGLYCEMIA; ACCUMULATION
AB Aim: Obesity based on insulin resistance is a state of chronic oxidative stress and inflammation that are highly regulated through nuclear factor Erythroid 2-related factor 2 (NrF2) pathway.
   Materials and methods: 70 male Wistar rats were randomized into two models. The prophylactic model was 10 weeks and rats were grouped into: normal group, GL group (received glycyrrhizin 50 mg/kg/day orally along with normal pellet diet), HFD group and HFD+ GL group (received glycyrrhizin along with HFD). The treatment model was 14 weeks and rats were grouped into: normal group, HFD group and HFD+ GL group (received glycyrrhizin from the week 10).
   Key findings: Glycyrrhizin decreased significantly rat weights and insulin resistance, normalized lipid profile and reduced significantly the adipocytes size in adipose tissue and lipid deposition in the liver tissue through histopathologic examination. Furthermore, glycyrrhizin ameliorated obesity-induced oxidative stress which indicated by significant decrease in liver malondialdehyde level (P < 0.001) and increase in the total antioxidant capacity (P < 0.001). Interestingly, molecular mechanism of glycyrrhizin was explored, that included significant reduction of liver gluconeogenic enzymes mRNA expression (P < 0.001), a significant increase of liver insulin receptor, NrF2 and homooxygenase-1 mRNA expressions (P < 0.001) and significant increase and nuclear translocation of NrF2 in liver tissue.
   Significance: Glycyrrhizin ameliorates HFD-induced obesity in rats that may be attributed to its ability to increase insulin receptor expression and to activate NrF2 and subsequent homooxygenase-1 pathway. Thus, this work represents a safe natural compound (glycyrrhizin) that has a great role either as prophylaxis or treatment for insulin resistance related to obesity.
C1 [El-Magd, Nada F. Abo; El-Mesery, Mohamed; El-Shishtawy, Mamdouh M.] Mansoura Univ, Dept Biochem, Fac Pharm, Mansoura 35516, Egypt.
   [El-Karef, Amro] Mansoura Univ, Dept Pathol, Fac Med, Mansoura 35516, Egypt.
C3 Egyptian Knowledge Bank (EKB); Mansoura University; Egyptian Knowledge
   Bank (EKB); Mansoura University
RP El-Shishtawy, MM (corresponding author), Mansoura Univ, Dept Biochem, Fac Pharm, Mansoura 35516, Egypt.
EM mshisht@mans.edu.eg
RI Abo El-Magd, Nada/O-5930-2018; El-Shishtawy, Mamdouh/O-6626-2018;
   El-Mesery, Mohamed/ADM-7145-2022
OI Fawzy, Nada/0000-0003-2896-2802
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NR 47
TC 49
Z9 49
U1 2
U2 28
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0024-3205
EI 1879-0631
J9 LIFE SCI
JI Life Sci.
PD JAN 15
PY 2018
VL 193
BP 159
EP 170
DI 10.1016/j.lfs.2017.11.005
PG 12
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA FR4HV
UT WOS:000419027200018
PM 29129772
DA 2025-06-11
ER

PT J
AU Soroush, N
   Radfar, M
   Hamidi, AK
   Abdollahi, M
   Qorbani, M
   Razi, F
   Esfahani, EN
   Amoli, MM
AF Soroush, Negin
   Radfar, Mania
   Hamidi, Armita Kakavand
   Abdollahi, Mohammad
   Qorbani, Mostafa
   Razi, Farideh
   Esfahani, Ensieh Nasli
   Amoli, Mahsa M.
TI Vitamin D receptor gene FokI variant in diabetic foot ulcer and
   its relation with oxidative stress
SO GENE
LA English
DT Article
DE VDR gene polymorphism; Diabetic foot ulcer; Type 2 diabetes; Oxidative
   stress
ID INSULIN-RESISTANCE; D DEFICIENCY; METABOLIC SYNDROME; POLYMORPHISMS;
   INFLAMMATION; RISK; ASSOCIATIONS; MARKERS; BLOOD; BSMI
AB Purpose: The patient's suffering and financial costs affiliated with Diabetic Foot Ulcer (DFU), as one of the most important complications of diabetes, are highly undesirable and this highlights the importance of preventive medicine about this disorder. Furthermore hyperglycemia causes generation of free radicals which leads to oxidative stress (OS). Hence, this study aims to examine the association between vitamin D receptor (VDR) gene FokI polymorphism and DFU in Iranian population and also its correlation with OS biomarkers.
   Materials and methods: In a case-control study, a total of 212 patients with type 2 diabetes with and without diabetic foot ulcer were included. Genotyping was conducted by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) analysis. Samples were analyzed for thiobarbituric reactive substances (TBARS) and ferric reducing ability of plasma (FRAP) as markers of OS.
   Results: The results indicated a significant difference in genotype frequencies of VDR gene Fold polymorphism in patients with diabetic foot ulcer in comparison to those without diabetic foot ulcer (IT + TC vs. CC p = 0.04; OR = 1.76; 95% CI = 1.02-3.05). Moreover, the patients carrying the T allele had a significantly higher level of TBARS (p = 0.01).
   Conclusions: We found a significant association between Fold functional variant of VDR gene and diabetic foot ulcer in an Iranian population. Increased levels of TBARS in patients carrying the T allele of FokI polymorphism indicate an association between this variant and OS in patients with diabetes. (C) 2016 Elsevier B.V. All rights reserved.
C1 [Soroush, Negin; Radfar, Mania] Univ Tehran Med Sci, Dept Clin Pharm, Fac Pharm, Tehran, Iran.
   [Radfar, Mania] Univ Tehran Med Sci, Endocrinol & Metab Clin Sci Inst, Endocrinol & Metab Res Ctr, Tehran, Iran.
   [Hamidi, Armita Kakavand; Amoli, Mahsa M.] Univ Tehran Med Sci, Endocrinol & Metab Mol Cellular Sci Inst, Metab Disorders Res Ctr, Tehran, Iran.
   [Abdollahi, Mohammad] Univ Tehran Med Sci, Dept Pharmacol & Toxicol, Fac Pharm, Tehran, Iran.
   [Qorbani, Mostafa] Alborz Univ Med Sci, Sch Med, Dept Community Med, Karaj, Iran.
   [Razi, Farideh; Esfahani, Ensieh Nasli] Univ Tehran Med Sci, Endocrinol & Metab Clin Sci Inst, Diabet Res Ctr, Tehran, Iran.
C3 Tehran University of Medical Sciences; Tehran University of Medical
   Sciences; Tehran University of Medical Sciences; Tehran University of
   Medical Sciences; Alborz University of Medical Sciences; Tehran
   University of Medical Sciences
RP Radfar, M; Amoli, MM (corresponding author), Dr Shariati Hosp, EMRI, North Karegar St, Tehran 1411413137, Iran.
EM radfarma@tums.ac.ir; amolimm@tums.ac.ir
RI Qorbani, Mostafa/M-8171-2017; Razi, Farideh/ABG-3808-2021; /B-9232-2008
OI /0000-0003-0123-1209; Amoli, Mahsa/0000-0002-9168-9223; Qorbani,
   Mostafa/0000-0001-9465-7588; Razi, Farideh/0000-0003-2350-9574
FU EMRI, Tehran University of Medical Sciences [1392-01-86-1550]
FX This study has been funded by EMRI, Tehran University of Medical
   Sciences (1392-01-86-1550).
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NR 38
TC 21
Z9 24
U1 0
U2 23
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0378-1119
EI 1879-0038
J9 GENE
JI Gene
PD JAN 30
PY 2017
VL 599
BP 87
EP 91
DI 10.1016/j.gene.2016.11.012
PG 5
WC Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Genetics & Heredity
GA EF9AJ
UT WOS:000390622800009
PM 27836663
DA 2025-06-11
ER

PT J
AU Williams, AS
   Mathews, JA
   Kasahara, DI
   Wurmbrand, AP
   Chen, L
   Shore, SA
AF Williams, Alison Suzanne
   Mathews, Joel Andrew
   Kasahara, David Itiro
   Wurmbrand, Allison Patricia
   Chen, Lucas
   Shore, Stephanie Ann
TI Innate and ozone-induced airway hyperresponsiveness in obese mice: role
   of TNF-α
SO AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
LA English
DT Article
DE bronchoalveolar lavage; systemic inflammation; hyaluronan; osteopontin;
   IL-13
ID TUMOR-NECROSIS-FACTOR; PULMONARY RESPONSES; OXIDATIVE STRESS; METABOLIC
   SYNDROME; LUNG INFLAMMATION; BARIATRIC SURGERY; ALLERGIC-ASTHMA;
   T-CELLS; EXPOSURE; EXPRESSION
AB Innate airway hyperresponsiveness (AHR) and augmented responses to ozone, an asthma trigger, are characteristics of obese mice. Systemic inflammation, a condition of increased circulating concentrations of inflammatory moieties, occurs in obesity. We hypothesized that TNF-alpha, via its effects as a master effector of this systemic inflammation, regulates innate AHR and augmented responses to ozone in obese mice. Therefore, we examined pulmonary inflammation and airway responsiveness in unexposed or ozone-exposed (2 ppm for 3 h) lean wild-type and obese Cpe(fat) mice that were TNF-alpha sufficient or deficient. Cpefat mice lack carboxypeptidase E, which regulates satiety. Compared with wild type, Cpe(fat) mice had elevated serum IL-17A, G-CSF, KC, MCP-1, IL-9, MIG, and leptin, indicating systemic inflammation. Despite reductions in most of these moieties in TNF-alpha-deficient vs. -sufficient Cpefat mice, we observed no substantial difference in airway responsiveness in these two groups of mice. Ozone-induced increases in bronchoalveolar lavage (BAL) neutrophils and macrophages were lower, but ozone-induced AHR and increases in BAL hyaluronan, osteopontin, IL-13, and protein carbonyls, a marker of oxidative stress, were augmented in TNF-alpha-deficient vs. -sufficient Cpe(fat) mice. Our data indicate that TNF-alpha has an important role in promoting the systemic inflammation but not the innate AHR of obesity, suggesting that the systemic inflammation of obesity is not the major driver of this AHR. TNF-alpha is required for the augmented effects of acute ozone exposure on pulmonary inflammatory cell recruitment in obese mice, whereas TNF-alpha protects against ozone-induced AHR in obese mice, possibly by suppressing ozone-induced oxidative stress.
C1 [Williams, Alison Suzanne; Mathews, Joel Andrew; Kasahara, David Itiro; Wurmbrand, Allison Patricia; Chen, Lucas; Shore, Stephanie Ann] Harvard Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA 02115 USA.
C3 Harvard University; Harvard T.H. Chan School of Public Health
RP Shore, SA (corresponding author), Harvard Univ, TH Chan Sch Publ Hlth, 665 Huntington Ave, Boston, MA 02115 USA.
EM sshore@hsph.harvard.edu
OI Chen, Lucas/0000-0002-9228-1959
FU U.S. National Institute of Health [ES-013307, HL-084044, ES-000002]; 
   [ES-022556]
FX This work was supported by the U.S. National Institute of Health grants
   ES-013307, HL-084044, and ES-000002. J.A. Mathews was supported by
   ES-022556.
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NR 61
TC 30
Z9 34
U1 0
U2 8
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 1040-0605
EI 1522-1504
J9 AM J PHYSIOL-LUNG C
JI Am. J. Physiol.-Lung Cell. Mol. Physiol.
PD JUN 1
PY 2015
VL 308
IS 11
BP L1168
EP L1177
DI 10.1152/ajplung.00393.2014
PG 10
WC Physiology; Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology; Respiratory System
GA CM2KQ
UT WOS:000357509200008
PM 25840999
OA Green Published
DA 2025-06-11
ER

PT J
AU Mehrzadi, S
   Safa, M
   Hosseinzadeh, A
AF Mehrzadi, Saeed
   Safa, Majid
   Hosseinzadeh, Azam
TI Investigating the Effects of Simultaneous Administration of Melatonin
   and Atorvastatin against High Glucose-Induced Oxidative Stress and
   Apoptosis in Cultured Chondrocytes
SO CURRENT RHEUMATOLOGY REVIEWS
LA English
DT Article; Early Access
DE Oxidative stress; diabetes; apoptosis; melatonin; atorvastatin;
   osteoarthritis; pharmacology
ID DAMAGE; MODEL
AB Objective Osteoarthritis (OA) is a prevalent joint disorder categorized into phenotypic subtypes, including those associated with age, traumatic events, and metabolic syndrome. In the aging population, type 2 diabetes mellitus (T2DM) and osteoarthritis (OA) frequently coexist. This can result in higher rates of disability and a greater financial burden. This study aimed to investigate the protective effects of melatonin and atorvastatin together against oxidative stress and apoptosis induced by high glucose in C28I2 human chondrocytes.Material and Methods After being pretreated for 6 hours with melatonin (10 and 100 mu M) and atorvastatin (0.01 and 0.1 mu M), C28I2 cells were exposed to a high concentration of D-glucose (75 mM) for 72 hours. The impact of a high D-glucose concentration (75 mM), with or without melatonin and/or atorvastatin, on cell viability, intra-cellular ROS generation, lipid peroxidation level, antioxidant activities, and the expression of proteins, including Bax, Bcl-2, and caspase-3, was analyzed.Results Melatonin and atorvastatin combination effectively inhibited high glucose-induced cytotoxicity, ROS production, and MDA and mitochondrial membrane potential levels. The combination of melatonin and atorvastatin was more successful in reducing ROS production compared to each of the drugs alone. Melatonin, but not atorvastatin, reversed high glucose-induced alteration in the catalase activity. Furthermore, the combination of melatonin and atorvastatin significantly enhanced the ability of each medication to lower the expression of pro-apoptotic protein Bax.Conclusion The combination of melatonin and atorvastatin exerted greater protective effects against hyperglycemia-induced toxicity in chondrocytes.
C1 [Mehrzadi, Saeed; Hosseinzadeh, Azam] Iran Univ Med Sci, Razi Drug Res Ctr, Tehran, Iran.
   [Safa, Majid] Iran Univ Med Sci, Fac Allied Med, Dept Hematol & Blood Banking, Tehran, Iran.
C3 Iran University of Medical Sciences; Iran University of Medical Sciences
RP Hosseinzadeh, A (corresponding author), Iran Univ Med Sci, Razi Drug Res Ctr, Tehran, Iran.
EM osseinzadeaza-m@gmail.com
RI Mehrzadi, Saeed/AAY-8389-2020; Hosseinzadeh, Azam/AAN-6886-2021
FU Iran University of Medical Sciences [1400-3-99-22547]
FX This study was supported by grant 1400-3-99-22547 from Iran University
   of Medical Sciences.
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NR 37
TC 1
Z9 1
U1 0
U2 0
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1573-3971
EI 1875-6360
J9 CURR RHEUMATOL REV
JI Curr. Rheumatol. Rev.
PD 2024 SEP 13
PY 2024
DI 10.2174/0115733971311626240828181223
EA SEP 2024
PG 11
WC Rheumatology
WE Emerging Sources Citation Index (ESCI)
SC Rheumatology
GA G3U8M
UT WOS:001315936600001
PM 39279705
DA 2025-06-11
ER

PT J
AU Qin, L
   Zhao, Y
   Zhang, B
   Li, Y
AF Qin, Li
   Zhao, Ying
   Zhang, Bin
   Li, Yan
TI Amentoflavone improves cardiovascular dysfunction and metabolic
   abnormalities in high fructose and fat diet-fed rats
SO FOOD & FUNCTION
LA English
DT Article
ID RENIN-ANGIOTENSIN SYSTEM; KAPPA-B ACTIVATION; HIGH-CARBOHYDRATE;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; FERULIC ACID; II RECEPTOR;
   HYPERTENSION; INHIBITION; INFLAMMATION
AB Metabolic syndrome (MS) is a leading cause of mortality and morbidity in Western countries. Amentoflavone (AMF) is a polyphenolic compound which has been found to exhibit various biological activities. In this study, we investigated the protective effects of AMF against cardiovascular and liver dysfunction in high fructose and fat diet (HFFD)-induced MS rats. AMF could evidently inhibit the changes of general metabolic parameters, including body weight, fat mass, insulin level, and glucose tolerance activity. AMF markedly protected against cardiovascular dysfunction, as evidenced by a decrease of systolic blood pressure, left ventricular internal diameter in diastole (LVIDd) and left ventricular posterior wall thickness in diastole (LVPWd); increase of fractional shortening; and decrease of ejection fraction, relative wall thickness, estimated LV mass, cardiac stiffness and LV wet weight in HFFD-fed rats. AMF also inhibited the increase of aortic vasoconstriction in response to phenylephrine and increased relaxation in response to acetylcholine in HFFD-fed rats. AMF reversed the HFFD-induced decrease of nitrogen oxide level, increase of type 1 Ang II receptor (AT-1A) expression and decrease of AT-2A expression. AMF reduced histological and functional injury and lipid accumulation in livers in MS rats. AMF also inhibited HFFDinduced oxidative stress, as reflected by the decrease of thiobarbituric acid reactive substance content, increase of GSH level, increase of superoxide dismutase and catalase activities, and decrease of NADPH oxidase activities. In summary, we showed that AMF exhibited protective effects against cardiovascular dysfunction and liver injury in MS rats. Inhibition of the renin-angiotensin system and oxidative stress contributes to cardiovascular and liver protective activities. Our data provide novel insights into the beneficial effects of AMF against MS.
C1 [Qin, Li; Li, Yan] Zhengzhou Univ, Zhengzhou Cent Hosp, Cardiovasc Med Ward 2, Zhengzhou 450000, Henan, Peoples R China.
   [Zhao, Ying] Zhengzhou Univ, Affiliated Hosp 1, Cardiovasc Med Ward 5, Zhengzhou 450000, Henan, Peoples R China.
   [Zhang, Bin] Xinxiang Med Univ, Affiliated Hosp 1, Clin Lab, Weihui 453100, Henan, Peoples R China.
C3 Zhengzhou University; Zhengzhou University; Xinxiang Medical University
RP Li, Y (corresponding author), Zhengzhou Univ, Zhengzhou Cent Hosp, Cardiovasc Med Ward 2, Zhengzhou 450000, Henan, Peoples R China.
EM ly_liyan222@126.com
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NR 48
TC 32
Z9 34
U1 1
U2 23
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PD JAN
PY 2018
VL 9
IS 1
BP 243
EP 252
DI 10.1039/c7fo01095h
PG 10
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA FT7RV
UT WOS:000423351400022
PM 29168869
DA 2025-06-11
ER

PT J
AU Mao, Y
   Luo, W
   Zhang, L
   Wu, WW
   Yuan, LS
   Xu, H
   Song, JH
   Fujiwara, K
   Abe, J
   LeMaire, SA
   Wang, XL
   Shen, YH
AF Mao, Yun
   Luo, Wei
   Zhang, Lin
   Wu, Weiwei
   Yuan, Liangshuai
   Xu, Hao
   Song, Juhee
   Fujiwara, Keigi
   Abe, Jun-ichi
   LeMaire, Scott A.
   Wang, Xing Li
   Shen, Ying H.
TI STING-IRF3 Triggers Endothelial Inflammation in Response to Free Fatty
   Acid-Induced Mitochondrial Damage in Diet-Induced Obesity
SO ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
LA English
DT Article
DE diet, high-fat; DNA, mitochondrial; endothelium; palmitic acid; vascular
   diseases
ID CYCLIC GMP-AMP; ENDOPLASMIC-RETICULUM STRESS; I IFN PRODUCTION; INNATE
   IMMUNITY; CYTOSOLIC DNA; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   DISEASE; ACTIVATION; INTERFERON
AB Objective-Metabolic stress in obesity induces endothelial inflammation and activation, which initiates adipose tissue inflammation, insulin resistance, and cardiovascular diseases. However, the mechanisms underlying endothelial inflammation induction are not completely understood. Stimulator of interferon genes (STING) is an important molecule in immunity and inflammation. In the present study, we sought to determine the role of STING in palmitic acid-induced endothelial activation/inflammation.
   Approach and Results-In cultured endothelial cells, palmitic acid treatment activated STING, as indicated by its perinuclear translocation and binding to interferon regulatory factor 3 (IRF3), leading to IRF3 phosphorylation and nuclear translocation. The activated IRF3 bound to the promoter of ICAM-1 (intercellular adhesion molecule 1) and induced ICAM-1 expression and monocyte-endothelial cell adhesion. When analyzing the upstream signaling, we found that palmitic acid activated STING by inducing mitochondrial damage. Palmitic acid treatment caused mitochondrial damage and leakage of mitochondrial DNA into the cytosol. Through the cytosolic DNA sensor cGAS (cyclic GMP-AMP synthase), the mitochondrial damage and leaked cytosolic mitochondrial DNA activated the STING-IRF3 pathway and increased ICAM-1 expression. In mice with diet-induced obesity, the STING-IRF3 pathway was activated in adipose tissue. However, STING deficiency (Sting(gt/gt)) partially prevented diet-induced adipose tissue inflammation, obesity, insulin resistance, and glucose intolerance.
   Conclusions-The mitochondrial damage-cGAS-STING-IRF3 pathway is critically involved in metabolic stress-induced endothelial inflammation. STING may be a potential therapeutic target for preventing cardiovascular diseases and insulin resistance in obese individuals.
C1 [Mao, Yun; Luo, Wei; Wu, Weiwei; Yuan, Liangshuai; Xu, Hao; Wang, Xing Li] Shandong Univ, Qilu Hosp, Res Ctr Cell Therapy, Key Lab Cardiovasc Remodeling & Funct Res, Jinan, Peoples R China.
   [Mao, Yun; Luo, Wei; Zhang, Lin; LeMaire, Scott A.; Wang, Xing Li; Shen, Ying H.] Baylor Coll Med, Dept Surg, Houston, TX 77030 USA.
   [Mao, Yun; Luo, Wei; Zhang, Lin; LeMaire, Scott A.; Wang, Xing Li; Shen, Ying H.] Texas Heart Inst, Dept Surg, Houston, TX 77025 USA.
   [Song, Juhee] Univ Texas MD Anderson Canc Ctr, Dept Biostat, Houston, TX 77030 USA.
   [Fujiwara, Keigi; Abe, Jun-ichi] Univ Texas MD Anderson Canc Ctr, Div Internal Med, Dept Cardiol Res, Houston, TX 77030 USA.
C3 Shandong University; Baylor College of Medicine; Texas Heart Institute;
   University of Texas System; UTMD Anderson Cancer Center; University of
   Texas System; UTMD Anderson Cancer Center
RP Shen, YH (corresponding author), Baylor Coll Med, One Baylor Plaza, Houston, TX 77030 USA.; Wang, XL (corresponding author), Qilu Hosp, 107 Wenhua West Rd, Jinan, Shandong, Peoples R China.
EM xingliwang@sdu.edu.cn; hyshen@bcm.edu
RI shen, ying/HHS-5635-2022; Wu, Weiwei/AFY-8257-2022; wang,
   xingli/MHR-1399-2025
OI Luo, Wei/0000-0001-9416-9592; LeMaire, Scott/0000-0002-8736-4266
FU 973 National Basic Research Program of China [2014CB542401]; National
   Institutes of Health [HL131980-01, HL-130193, HL-123346, HL-118462];
   American Heart Association [15GRNT23040007]; Shandong University
   National Qianren Scholar Fund; Cancer Center Support Grant (NCI) [P30
   CA016672]; American Heart Association (AHA) [15GRNT23040007] Funding
   Source: American Heart Association (AHA)
FX This study was supported by grants from 973 National Basic Research
   Program of China (2014CB542401 to X.L. Wang), National Institutes of
   Health (HL131980-01 to Y.H. Shen/S.A. LeMaire and HL-130193, HL-123346,
   and HL-118462 to J.-i. Abe), the American Heart Association
   (15GRNT23040007 to Y.H. Shen) and Shandong University National Qianren
   Scholar Fund (to X.L. Wang). The statistical analysis work was supported
   in part by the Cancer Center Support Grant (NCI Grant P30 CA016672).
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NR 42
TC 226
Z9 244
U1 2
U2 51
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1079-5642
EI 1524-4636
J9 ARTERIOSCL THROM VAS
JI Arterioscler. Thromb. Vasc. Biol.
PD MAY
PY 2017
VL 37
IS 5
BP 920
EP +
DI 10.1161/ATVBAHA.117.309017
PG 20
WC Hematology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Hematology; Cardiovascular System & Cardiology
GA EV7EX
UT WOS:000401939000027
PM 28302626
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Romandini, M
   Gioco, G
   Perfetti, G
   Deli, G
   Staderini, E
   Laforì, A
AF Romandini, Mario
   Gioco, Gioele
   Perfetti, Giorgio
   Deli, Giorgio
   Staderini, Edoardo
   Lafori, Andreina
TI The association between periodontitis and sleep duration
SO JOURNAL OF CLINICAL PERIODONTOLOGY
LA English
DT Article
DE association; epidemiology; inflammation; Korea National Health And
   Nutrition Examination Survey (KNHANES); oxidative stress; periodontal
   diseases; periodontitis; risk factors; sleep
ID KOREA NATIONAL-HEALTH; U-SHAPED ASSOCIATION; METABOLIC SYNDROME;
   SYSTEMIC INFLAMMATION; OXIDATIVE STRESS; RISK-FACTOR; SMOKING; DISEASE;
   ADULTS; HYPERTENSION
AB AimDue to its potential to influence systemic inflammation and oxidative stress, and to predispose to bacterial infections, sleep duration could potentially be a risk factor for periodontitis. The aim of this cross-sectional study was to evaluate if there was in 2012 an association between periodontitis and sleep duration in a representative sample of the South Korean population.
   Materials and MethodsA total of 5812 subjects representative of 39.4 million ofadults were examined. Multivariate logistic regressions were applied controlling for age, gender, education, smoking status, alcoholism and consumption frequency of coffee, tea, chocolate and red wine.
   ResultsCompared to the group sleeping 5h/day, the adjusted odds ratios for periodontitis prevalence defined as Community Periodontal Index (CPI)=4 were OR=2.46 (95% CI: 1.20-5.06) in the 6h/day sleepers group, OR=2.66 (95% CI: 1.35-5.25) in the 7h/day sleepers group, OR=2.29 (95% CI: 1.13-4.63) in the 8h/day sleepers group and OR=4.27 (95% CI: 1.83-9.97) in the 9h/day sleepers group. The association has shown to be highlighted in middle-aged people, females, non-smokers, lower educated, with lower lead and higher cadmium blood levels and with higher carotene dietary intake ones and to be partially mediated by lipid profile alterations, diabetes, serum Vitamin D levels and WBC count.
   ConclusionsA novel, direct and independent association between sleep duration and the prevalence of periodontitis was found. However, it needs to be investigated how the factors influencing the sleep duration affect this association.
C1 [Romandini, Mario; Gioco, Gioele; Deli, Giorgio; Staderini, Edoardo; Lafori, Andreina] Univ Cattolica Sacro Cuore, Sch Dent, Rome, Italy.
   [Romandini, Mario; Deli, Giorgio; Lafori, Andreina] Univ Cattolica Sacro Cuore, Dept Periodontol, Rome, Italy.
   [Romandini, Mario] G Eastman Dent Hosp, Dept Periodontol & Prosthodont, Rome, Italy.
   [Romandini, Mario; Perfetti, Giorgio] Univ G dAnnunzio, Dept Med Oral & Biotechnol Sci, Chieti, Italy.
C3 Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli;
   Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli; G
   d'Annunzio University of Chieti-Pescara
RP Romandini, M (corresponding author), Giovanni 23 Sq 24, I-74123 Taranto, Italy.
EM mario.romandini@gmail.com
RI Romandini, Mario/AAN-5233-2021; Lafori, Andreina/NGS-6065-2025; Gioco,
   Gioele/GVT-8887-2022; Staderini, Edoardo/ABH-6597-2020
OI Lafori, Andreina/0000-0001-5530-5280; Gioco, Gioele/0000-0002-8637-2029;
   Romandini, Mario/0000-0001-5646-083X; Staderini,
   Edoardo/0000-0003-1339-9172
FU Health Promotion Fund of Korea
FX The authors declare no conflicts of interest related to this study. This
   study was self-funded by the authors, however the data of 2012 of the
   Fifth Korea National Health And Nutrition Examination Survey (KNHANES V,
   2012) have been provided from the Korea Center for Disease Control and
   Prevention (KCDC). KNHANES V has been financially supported by the
   Health Promotion Fund of Korea with administrative support from the
   Korean Ministry of Health and Welfare.
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NR 64
TC 53
Z9 54
U1 0
U2 43
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0303-6979
EI 1600-051X
J9 J CLIN PERIODONTOL
JI J. Clin. Periodontol.
PD MAY
PY 2017
VL 44
IS 5
BP 490
EP 501
DI 10.1111/jcpe.12713
PG 12
WC Dentistry, Oral Surgery & Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dentistry, Oral Surgery & Medicine
GA EV0MW
UT WOS:000401435800005
PM 28211083
DA 2025-06-11
ER

PT J
AU Tucsek, Z
   Toth, P
   Tarantini, S
   Sosnowska, D
   Gautam, T
   Warrington, JP
   Giles, CB
   Wren, JD
   Koller, A
   Ballabh, P
   Sonntag, WE
   Ungvari, Z
   Csiszar, A
AF Tucsek, Zsuzsanna
   Toth, Peter
   Tarantini, Stefano
   Sosnowska, Danuta
   Gautam, Tripti
   Warrington, Junie P.
   Giles, Cory B.
   Wren, Jonathan D.
   Koller, Akos
   Ballabh, Praveen
   Sonntag, William E.
   Ungvari, Zoltan
   Csiszar, Anna
TI Aging Exacerbates Obesity-induced Cerebromicrovascular Rarefaction,
   Neurovascular Uncoupling, and Cognitive Decline in Mice
SO JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL
   SCIENCES
LA English
DT Article
DE Vascular cognitive impairment; MCI; Endothelial dysfunction; Learning
   and memory
ID VASCULAR OXIDATIVE STRESS; HIGH-FAT DIET; IMPAIRS ANGIOGENIC CAPACITY;
   CEREBRAL-BLOOD-FLOW; AGE-RELATED-CHANGES; GROWTH-HORMONE;
   ADIPOSE-TISSUE; ENDOTHELIAL FUNCTION; OLDER-ADULTS; METABOLIC SYNDROME
AB Epidemiological studies show that obesity has deleterious effects on the brain and cognitive function in the elderly population. However, the specific mechanisms through which aging and obesity interact to promote cognitive decline remain unclear. To test the hypothesis that aging exacerbates obesity-induced cerebromicrovascular impairment, we compared young (7 months) and aged (24 months) high-fat diet-fed obese C57BL/6 mice. We found that aging exacerbates the obesity-induced decline in microvascular density both in the hippocampus and in the cortex. The extent of hippocampal microvascular rarefaction and the extent of impairment of hippocampal-dependent cognitive function positively correlate. Aging exacerbates obesity-induced loss of pericyte coverage on cerebral microvessels and alters hippocampal angiogenic gene expression signature, which likely contributes to microvascular rarefaction. Aging also exacerbates obesity-induced oxidative stress and induction of NADPH oxidase and impairs cerebral blood flow responses to whisker stimulation. Collectively, obesity exerts deleterious cerebrovascular effects in aged mice, promoting cerebromicrovascular rarefaction and neurovascular uncoupling. The morphological and functional impairment of the cerebral microvasculature in association with increased blood-brain barrier disruption and neuroinflammation (Tucsek Z, Toth P, Sosnowsk D, et al. Obesity in aging exacerbates blood-brain barrier disruption, neuroinflammation and oxidative stress in the mouse hippocampus: effects on expression of genes involved in beta-amyloid generation and Alzheimer's disease. J Gerontol Biol Med Sci. 2013. In press, PMID: 24269929) likely contribute to obesity-induced cognitive decline in aging.
C1 [Tucsek, Zsuzsanna; Toth, Peter; Tarantini, Stefano; Sosnowska, Danuta; Gautam, Tripti; Warrington, Junie P.; Sonntag, William E.; Ungvari, Zoltan; Csiszar, Anna] Univ Oklahoma, Hlth Sci Ctr, Reynolds Oklahoma Ctr Aging, Donald W Reynolds Dept Geriatr Med, Oklahoma City, OK 73104 USA.
   [Warrington, Junie P.] Univ Mississippi, Med Ctr, Dept Physiol & Biophys, Jackson, MS USA.
   [Giles, Cory B.; Wren, Jonathan D.] Oklahoma Med Res Fdn, Arthrit & Clin Immunol Res Program, Oklahoma City, OK USA.
   [Koller, Akos; Ungvari, Zoltan; Csiszar, Anna] Univ Pecs, Sch Med, Dept Pathophysiol & Gerontol, Pecs, Hungary.
   [Koller, Akos; Ungvari, Zoltan; Csiszar, Anna] Univ Pecs, Szentagothai Res Ctr, Pecs, Hungary.
   [Ballabh, Praveen] New York Med Coll, Westchester Med Ctr, Dept Pediat, Valhalla, NY 10595 USA.
   [Ballabh, Praveen] New York Med Coll, Westchester Med Ctr, Dept Anat, Valhalla, NY 10595 USA.
   [Ballabh, Praveen] New York Med Coll, Westchester Med Ctr, Dept Cell Biol, Valhalla, NY 10595 USA.
   [Ungvari, Zoltan; Csiszar, Anna] Univ Oklahoma, Hlth Sci Ctr, Dept Physiol, Oklahoma City, OK 73104 USA.
C3 University of Oklahoma System; University of Oklahoma Health Sciences
   Center; University of Mississippi; University of Mississippi Medical
   Center; Oklahoma Medical Research Foundation; University of Pecs;
   University of Pecs; Westchester Medical Center; New York Medical
   College; Westchester Medical Center; New York Medical College; New York
   Medical College; Westchester Medical Center; University of Oklahoma
   System; University of Oklahoma Health Sciences Center
RP Ungvari, Z (corresponding author), Univ Oklahoma, Hlth Sci Ctr, Reynolds Oklahoma Ctr Aging, Dept Geriatr Med, 975 N E 10th St BRC 1303, Oklahoma City, OK 73104 USA.
EM zoltan-ungvari@ouhsc.edu
RI Tarantini, Stefano/JMQ-7733-2023; Warrington, Junie/I-5782-2019;
   Sosnowska, Danuta/KHD-9993-2024; Ákos, Koller/Q-4672-2019; Wren,
   Jonathan/E-5611-2011; Ungvari, Zoltan/GZK-8127-2022
OI Giles, Cory/0000-0002-7745-5914; Warrington, Junie/0000-0001-5626-8872;
   Sonntag, William/0000-0003-1850-2407; Sosnowska,
   Danuta/0000-0002-2291-5987
FU American Heart Association; National Center for Complementary and
   Alternative Medicine [R01-AT006526]; National Institute on Aging
   [AG031085, AG038747]; American Federation for Aging Research; Oklahoma
   Center for the Advancement of Science and Technology; Hungarian
   Scientific Research Fund [OTKA-K108444]; Nemzeti Fejlesztesi Ugynokseg
   (Developing Competitiveness of Universities in the South Transdanubian
   Region) [SROP-4.2.2.A-11/1/KONV-2012-0017,
   SROP-4.2.2.A-11/1/KONV-2012-0024]; Ellison Medical Foundation
FX This work was supported by grants from the American Heart Association
   (to Z.T., P. T., A. C., and Z.U.), the National Center for Complementary
   and Alternative Medicine (R01-AT006526 to Z.U.), the National Institute
   on Aging (AG031085 to A. C.; AG038747 to W. E. S.), the American
   Federation for Aging Research (to A. C.), the Oklahoma Center for the
   Advancement of Science and Technology (to A. C., Z.U., W. E. S.),
   Hungarian Scientific Research Fund (OTKA-K108444), the Nemzeti
   Fejlesztesi Ugynokseg (Developing Competitiveness of Universities in the
   South Transdanubian Region, "Identification of new biomarkers,"
   SROP-4.2.2.A-11/1/KONV-2012-0017 and "Complex examination of
   neuropeptides" SROP-4.2.2.A-11/1/KONV-2012-0024 to A. K.), and the
   Ellison Medical Foundation (to W.E.S.).
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NR 81
TC 148
Z9 165
U1 0
U2 27
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1079-5006
EI 1758-535X
J9 J GERONTOL A-BIOL
JI J. Gerontol. Ser. A-Biol. Sci. Med. Sci.
PD NOV
PY 2014
VL 69
IS 11
BP 1339
EP 1352
DI 10.1093/gerona/glu080
PG 14
WC Geriatrics & Gerontology; Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA AT0YU
UT WOS:000344660900005
PM 24895269
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Hansen, JB
   Moen, IW
   Mandrup-Poulsen, T
AF Hansen, J. B.
   Moen, I. W.
   Mandrup-Poulsen, T.
TI Iron: the hard player in diabetes pathophysiology
SO ACTA PHYSIOLOGICA
LA English
DT Review
DE inflammation; iron transport; mitochondrial stress; oxidative stress;
   reactive oxygen species; -cell
ID PANCREATIC BETA-CELLS; ELEVATED SERUM FERRITIN; METAL-ION TRANSPORTER;
   NF-KAPPA-B; INSULIN-SECRETION; HEREDITARY HEMOCHROMATOSIS; OXIDATIVE
   STRESS; GLUCOSE-HOMEOSTASIS; DEFEROXAMINE THERAPY; METABOLIC SYNDROME
AB The interest in the role of ferrous iron in diabetes pathophysiology has been revived by recent evidence of iron as an important determinant of pancreatic islet inflammation and as a biomarker of diabetes risk and mortality. The iron metabolism in the -cell is complex. Excess free iron is toxic, but at the same time, iron is required for normal -cell function and thereby glucose homeostasis. In the pathogenesis of diabetes, iron generates reactive oxygen species (ROS) by participating in the Fenton chemistry, which can induce oxidative damage and apoptosis. The aim of this review is to present and discuss recent evidence, suggesting that iron is a key pathogenic factor in both type 1 and type 2 diabetes with a focus on inflammatory pathways. Pro-inflammatory cytokine-induced -cell death is not fully understood, but may include iron-induced ROS formation resulting in dedifferentiation by activation of transcription factors, activation of the mitochondrial apoptotic machinery or of other cell death mechanisms. The pro-inflammatory cytokine IL-1 facilitates divalent metal transporter 1 (DMT1)-induced -cell iron uptake and consequently ROS formation and apoptosis, and we propose that this mechanism provides the relay between inflammation and oxidative -cell damage. Iron chelation may be a potential therapeutic approach to reduce disease severity and mortality among diabetes patients. However, the therapeutic effect and safety of iron reduction need to be tested in clinical trials before dietary interventions or the use of iron chelation therapy titrated to avoid anaemia.
C1 [Hansen, J. B.; Moen, I. W.; Mandrup-Poulsen, T.] Univ Copenhagen, Dept Biomed Sci, Sect Endocrinol Res, Copenhagen, Denmark.
   [Hansen, J. B.] Univ Toronto, Dept Physiol, Toronto, ON M5S 1A8, Canada.
   [Mandrup-Poulsen, T.] Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden.
C3 University of Copenhagen; University of Toronto; Karolinska Institutet
RP Hansen, JB (corresponding author), Univ Toronto, Dept Physiol, 1 Kings Coll Circle, Toronto, ON M5S 1A8, Canada.
EM jakobha@sund.ku.dk
RI Hansen, Jacob/F-3775-2010
OI Hansen, Jakob Bondo/0000-0002-6837-0919; Mandrup-Poulsen,
   Thomas/0000-0002-3215-9273
FU Danish Council for Independent Research, Medical Sciences
FX Jakob Bondo Hansen was supported by a grant from the Danish Council for
   Independent Research, Medical Sciences.
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NR 106
TC 120
Z9 126
U1 1
U2 53
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1748-1708
EI 1748-1716
J9 ACTA PHYSIOL
JI Acta Physiol.
PD APR
PY 2014
VL 210
IS 4
BP 717
EP 732
DI 10.1111/apha.12256
PG 16
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA AC8BI
UT WOS:000332757600007
PM 24521359
DA 2025-06-11
ER

PT J
AU Babbar, L
   Mahadevan, N
   Balakumar, P
AF Babbar, Lalita
   Mahadevan, Nanjaian
   Balakumar, Pitchai
TI Fenofibrate attenuates impaired ischemic preconditioning-mediated
   cardioprotection in the fructose-fed hypertriglyceridemic rat heart
SO NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
LA English
DT Article
DE Fructose feeding; Hypertriglyceridemia; Myocardial I/R injury; Ischemic
   preconditioning
ID ACTIVATED RECEPTOR-ALPHA; MYOCARDIAL INFARCT SIZE; ISCHEMIA/REPERFUSION
   INJURY; REPERFUSION INJURY; METABOLIC SYNDROME; HYPERTENSIVE-RATS;
   OXIDATIVE STRESS; FREE-RADICALS; NITRIC-OXIDE; PROTECTION
AB We investigated in this study whether or not the ischemic preconditioning (IPC)-mediated cardioprotective effect against ischemia-reperfusion (I/R) injury exists in the fructose-fed hypertriglyceridemic (HTG) rat heart. Langendorff-perfused normal and fructose-fed (10 % w/v in drinking water, 8 weeks) HTG rat hearts were subjected to 30-min global ischemia and 120-min reperfusion. IPC protocol included four brief episodes (5 min each) of ischemia and reperfusion. Myocardial infarct size using triphenyltetrazolium chloride staining, markers of cardiac injury such as lactate dehydrogenase (LDH) and creatine kinase (CK-MB) release, coronary flow rate (CFR), and myocardial oxidative stress were assessed. High degree of myocardial I/R injury, by means of significant myocardial infarct size, elevated coronary LDH and CK-MB release, reduced CFR, and high oxidative stress, was noted in the HTG rat heart as compared to the normal rat heart. The IPC-mediated cardioprotection against I/R injury was markedly impaired in the HTG rat heart as compared to the normal rat heart. Interestingly, pharmacological reduction of triglycerides using 8-week treatment protocol with fenofibrate (80 mg/kg/day, p.o.) restored the IPC effect in the HTG rat heart that was blunted by coinfusion, during the IPC reperfusion protocol, of a specific inhibitor of phosphoinositide-3-kinase (PI3-K), wortmannin (100 nM). The IPC failed to protect the HTG rat heart against I/R injury. Fenofibrate treatment reduced high triglycerides in the fructose-fed HTG rat and subsequently restored the cardioprotective effect of IPC.
C1 [Babbar, Lalita; Balakumar, Pitchai] Rajendra Inst Technol & Sci, Dept Pharmacol, Cardiovasc Pharmacol Div, Sirsa 125055, India.
   [Mahadevan, Nanjaian] Rajendra Inst Technol & Sci, Inst Pharm, Sirsa 125055, India.
RP Balakumar, P (corresponding author), Rajendra Inst Technol & Sci, Dept Pharmacol, Cardiovasc Pharmacol Div, Sirsa 125055, India.
EM pbala2006@gmail.com
RI Balakumar, Pitchai/IVV-0100-2023
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NR 62
TC 13
Z9 13
U1 0
U2 18
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0028-1298
J9 N-S ARCH PHARMACOL
JI Naunyn-Schmiedebergs Arch. Pharmacol.
PD APR
PY 2013
VL 386
IS 4
BP 319
EP 329
DI 10.1007/s00210-012-0830-3
PG 11
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 108DK
UT WOS:000316271500007
PM 23325365
DA 2025-06-11
ER

PT J
AU Lu, X
   Xie, QX
   Pan, XH
   Zhang, RN
   Zhang, XY
   Peng, G
   Zhang, YW
   Shen, SM
   Tong, NW
AF Lu, Xi
   Xie, Qingxing
   Pan, Xiaohui
   Zhang, Ruining
   Zhang, Xinyi
   Peng, Ge
   Zhang, Yuwei
   Shen, Sumin
   Tong, Nanwei
TI Type 2 diabetes mellitus in adults: pathogenesis, prevention and therapy
SO SIGNAL TRANSDUCTION AND TARGETED THERAPY
LA English
DT Review
ID LIFE-STYLE INTERVENTION; FATTY LIVER-DISEASE; NF-KAPPA-B; IMPAIRED
   GLUCOSE-TOLERANCE; ENDOPLASMIC-RETICULUM STRESS; ACTIVATED
   RECEPTOR-GAMMA; BETA-CELL DEDIFFERENTIATION; INITIAL COMBINATION
   THERAPY; RANDOMIZED CONTROLLED-TRIAL; MUSCLE INSULIN-RESISTANCE
AB Type 2 diabetes (T2D) is a disease characterized by heterogeneously progressive loss of islet beta cell insulin secretion usually occurring after the presence of insulin resistance (IR) and it is one component of metabolic syndrome (MS), and we named it metabolic dysfunction syndrome (MDS). The pathogenesis of T2D is not fully understood, with IR and beta cell dysfunction playing central roles in its pathophysiology. Dyslipidemia, hyperglycemia, along with other metabolic disorders, results in IR and/or islet beta cell dysfunction via some shared pathways, such as inflammation, endoplasmic reticulum stress (ERS), oxidative stress, and ectopic lipid deposition. There is currently no cure for T2D, but it can be prevented or in remission by lifestyle intervention and/or some medication. If prevention fails, holistic and personalized management should be taken as soon as possible through timely detection and diagnosis, considering target organ protection, comorbidities, treatment goals, and other factors in reality. T2D is often accompanied by other components of MDS, such as preobesity/obesity, metabolic dysfunction associated steatotic liver disease, dyslipidemia, which usually occurs before it, and they are considered as the upstream diseases of T2D. It is more appropriate to call "diabetic complications" as "MDS-related target organ damage (TOD)", since their development involves not only hyperglycemia but also other metabolic disorders of MDS, promoting an up-to-date management philosophy. In this review, we aim to summarize the underlying mechanism, screening, diagnosis, prevention, and treatment of T2D, especially regarding the personalized selection of hypoglycemic agents and holistic management based on the concept of "MDS-related TOD".
C1 [Lu, Xi; Xie, Qingxing; Pan, Xiaohui; Zhang, Ruining; Zhang, Xinyi; Peng, Ge; Zhang, Yuwei; Shen, Sumin; Tong, Nanwei] Sichuan Univ, West China Hosp, Res Ctr Diabet & Metab, Dept Endocrinol & Metab, Chengdu, Peoples R China.
C3 Sichuan University
RP Tong, NW (corresponding author), Sichuan Univ, West China Hosp, Res Ctr Diabet & Metab, Dept Endocrinol & Metab, Chengdu, Peoples R China.
EM tongnw@scu.edu.cn
RI Zhang, Ruining/LTD-3094-2024; peng, ge/JAZ-0446-2023
FU National Nature Science Foundation of China [82170830]; West China
   Hospital; Sichuan University [ZYGD 18017)]; Nature Science Foundation of
   Department of Science and Technology of Sichuan Province (China)
   [2023YFS0078]
FX This work was supported by the National Nature Science Foundation of
   China (82170830), grants from the 1.3.5 project for disciplines of
   excellence, West China Hospital, Sichuan University (No. ZYGD 18017),
   and grants from Nature Science Foundation of Department of Science and
   Technology of Sichuan Province (China) (2023YFS0078). We acknowledge the
   contribution of Huang Jishu from East China of Architectural Design &
   Research Institute in the beautification of the images in this article.
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NR 353
TC 56
Z9 57
U1 18
U2 31
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 2095-9907
EI 2059-3635
J9 SIGNAL TRANSDUCT TAR
JI Signal Transduct. Target. Ther.
PD OCT 2
PY 2024
VL 9
IS 1
AR 262
DI 10.1038/s41392-024-01951-9
PG 25
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA H9O9U
UT WOS:001326665900002
PM 39353925
OA gold
DA 2025-06-11
ER

PT J
AU Wang, Q
   Li, H
   Lu, HH
   Wang, SM
   Li, YX
   Zhang, ZF
   Han, J
   Yang, Z
   Yang, YP
   Hong, Y
AF Wang, Qi
   Li, Hong
   Lu, Henghao
   Wang, Shumin
   Li, Yuxiu
   Zhang, Zhenfen
   Han, Jing
   Yang, Zhe
   Yang, Yanping
   Hong, Yan
TI SAA1 exacerbates pancreatic β-cell dysfunction through activation of
   NF-κB signaling in high-fat diet-induced type 2 diabetes mice
SO MOLECULAR AND CELLULAR ENDOCRINOLOGY
LA English
DT Article
DE Serum amyloid 1; Pancreatic beta-cells; Type 2 diabetes; NF-kappa B;
   High-fat diet
ID SERUM-AMYLOID-A; INSULIN-RESISTANCE; GENE-EXPRESSION; OBESITY;
   INFLAMMATION; SECRETION; MITOCHONDRIA; MECHANISM; MELLITUS; RECEPTOR
AB Insufficient decompensated insulin secretion and insulin resistance caused by pancreatic beta-cell dysfunction are the pathological bases of type 2 diabetes mellitus (T2DM). Glucolipotoxicity in pancreatic beta-cells is an important factor leading to their dysfunction, closely related to inflammatory signals, oxidative stress, mitochondrial dysfunction, and endoplasmic reticulum stress (ERs). However, there may be other unproven regulatory mechanisms that govern pancreatic beta-cell dysfunction. Therefore, further elucidation of the underlying mechanisms that lead to pancreatic beta-cells dysfunction will provide a sufficient theoretical basis for the more effective prevention and treatment of T2DM. As a stress protein with pro-inflammatory properties, Serum Amyloid 1 (SAA1) promotes the progression of metabolic syndrome-related diseases by activating immune cells and damaging endothelial cells. In the development of T2DM, the activation of nuclear factor-kappa B (NF-kappa B) signaling aggravates pancreatic beta-cells dysfunction under the stimulation of free fatty acids (FFAs), inflammatory factors, and chemokines. Moreover, the facilitating effect of SAA1 on the activation of the NF-kappa B signaling pathway has been demonstrated in other studies. In the present study, we demonstrated that SAA1 inhibits insulin secretion and promotes apoptotic molecular expression in pancreatic cells and islets and that NF-kappa B signaling inhibitors could reduce this effect of SAA1. SAA1 deficiency improved high-fat diet (HFD)-induced pancreatic 13 -cell dysfunction and decreased expression of NF-kappa B signaling molecules. Our findings suggested that HFD-induced SAA1 might exacerbate T2DM by enhancing pancreatic beta-cell dysfunction; such a function of SAA1 might depend on NF-kappa B signaling activation.
C1 [Wang, Qi; Li, Hong; Lu, Henghao; Wang, Shumin; Li, Yuxiu; Zhang, Zhenfen; Han, Jing; Yang, Zhe; Yang, Yanping; Hong, Yan] Guizhou Med Univ, Sch Basic Med, Dept Histol & Embryol, Dongqing Rd, Guiyang 550025, Guizhou, Peoples R China.
C3 Guizhou Medical University
RP Hong, Y (corresponding author), Guizhou Med Univ, Sch Basic Med, Dept Histol & Embryol, Dongqing Rd, Guiyang 550025, Guizhou, Peoples R China.
EM hongyanb@163.com
RI Wang, Qi/AAP-2821-2021; Li, Yuxiu/AAE-1202-2022; Yang,
   Yanping/I-1614-2018
FU National Nature Science Foundation of China [81860154, 81960383];
   Guizhou province Science and Technology Department [Qiankehejichu-ZK
   (2021) 404]; Fund of Guizhou Province Science and Technology Department
   [Qiankezhicheng (2018) 2784]; Guizhou Provincial Education Department
   Youth Science and Technology Talent Growth Project [Qianjiaohe KY (2021)
   150]; Guizhou Provincial Health Commission [gzwkj2022-254];
   Administration of Traditional Chinese Medicine Project [QZYY-2022-030];
   National innovation and Entrepreneurship training program for college
   students [202210660068]
FX The work was supported by the National Nature Science Foundation of
   China [grant number 81860154] ; the National Nature Science Foundation
   of China [grant number 81960383] ; Guizhou province Science and
   Technology Department [Qiankehejichu-ZK (2021) 404] ; the Fund of
   Guizhou Province Science and Technology Department [grant number
   Qiankezhicheng (2018) 2784] ; Guizhou Provincial Education Department
   Youth Science and Technology Talent Growth Project [grant number
   Qianjiaohe KY (2021) 150] ; Guizhou Provincial Health Commission [grant
   number gzwkj2022-254] ; Administration of Traditional Chinese Medicine
   Project [grant number QZYY-2022-030] ; National innovation and
   Entrepreneurship training program for college students [grant number
   202210660068] .
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PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0303-7207
EI 1872-8057
J9 MOL CELL ENDOCRINOL
JI Mol. Cell. Endocrinol.
PD OCT 1
PY 2023
VL 576
AR 112043
DI 10.1016/j.mce.2023.112043
EA AUG 2023
PG 12
WC Cell Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Endocrinology & Metabolism
GA S1YR0
UT WOS:001069200700001
PM 37574124
DA 2025-06-11
ER

PT J
AU Marchini, T
   Zirlik, A
   Wolf, D
AF Marchini, Timoteo
   Zirlik, Andreas
   Wolf, Dennis
TI Pathogenic Role of Air Pollution Particulate Matter in Cardiometabolic
   Disease: Evidence from Mice and Humans
SO ANTIOXIDANTS & REDOX SIGNALING
LA English
DT Review
DE air pollution; particulate matter; obesity; metabolic syndrome; adipose
   tissue; inflammation
ID LONG-TERM EXPOSURE; ENDOTHELIAL PROGENITOR CELLS; ADIPOSE-TISSUE
   INFLAMMATION; CAUSES VASCULAR DYSFUNCTION; DIESEL EXHAUST PARTICLES;
   OXIDATIVE STRESS; REACTIVE OXYGEN; INSULIN-RESISTANCE;
   MYOCARDIAL-INFARCTION; CARDIOVASCULAR-DISEASE
AB Significance:Air pollution is a considerable global threat to human health that dramatically increases the risk for cardiovascular pathologies, such as atherosclerosis, myocardial infarction, and stroke. An estimated 4.2 million cases of premature deaths worldwide are attributable to outdoor air pollution. Among multiple other components, airborne particulate matter (PM) has been identified as the major bioactive constituent in polluted air. While PM-related illness was historically thought to be confined to diseases of the respiratory system, overwhelming clinical and experimental data have now established that acute and chronic exposure to PM causes a systemic inflammatory and oxidative stress response that promotes cardiovascular disease. Recent Advances:A large body of evidence has identified an impairment of redox metabolism and the generation of oxidatively modified lipids and proteins in the lung as initial tissue response to PM. In addition, the pathogenicity of PM is mediated by an inflammatory response that involves PM uptake by tissue-resident immune cells, the activation of proinflammatory pathways in various cell types and organs, and the release of proinflammatory cytokines as locally produced tissue response signals that have the ability to affect organ function in a remote manner. Critical Issues:In the present review, we summarize and discuss the functional participation of PM in cardiovascular pathologies and its risk factors with an emphasis on how oxidative stress, inflammation, and immunity interact and synergize as a response to PM. Future Directions:The impact of PM constituents, doses, and novel anti-inflammatory therapies against PM-related illness is also discussed.
C1 [Marchini, Timoteo; Wolf, Dennis] Univ Heart Ctr Freiburg, Dept Cardiol & Angiol 1, Freiburg, Germany.
   [Marchini, Timoteo; Wolf, Dennis] Univ Freiburg, Fac Med, Freiburg, Germany.
   [Zirlik, Andreas] Med Univ Graz, Univ Heart Ctr Graz, Dept Cardiol, Graz, Austria.
C3 Universitats Herzzentrum Freiburg; University of Freiburg; Medical
   University of Graz
RP Zirlik, A (corresponding author), Med Univ Graz, LKH Univ Klinikum Graz, Klin Innere Med Abt Kardiol, Auenbruggerpl 15, A-8036 Graz, Austria.
EM andreas.zirlik@medunigraz.at
RI Marchini, Timoteo/AAN-3444-2020; Wolf, Dennis/S-9217-2018; Zirlik,
   Andreas/A-6400-2011
OI Wolf, Dennis/0000-0003-1525-4348; Marchini, Timoteo/0000-0002-5758-4348;
   Zirlik, Andreas/0000-0001-6290-3297
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NR 164
TC 44
Z9 46
U1 0
U2 18
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1523-0864
EI 1557-7716
J9 ANTIOXID REDOX SIGN
JI Antioxid. Redox Signal.
PD AUG 1
PY 2020
VL 33
IS 4
BP 263
EP 279
DI 10.1089/ars.2020.8096
PG 17
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA MG6RD
UT WOS:000546155800003
PM 32403947
DA 2025-06-11
ER

PT J
AU Strazhesko, I
   Tkacheva, O
   Boytsov, S
   Akasheva, D
   Dudinskaya, E
   Vygodin, V
   Skvortsov, D
   Nilsson, P
AF Strazhesko, Irina
   Tkacheva, Olga
   Boytsov, Sergey
   Akasheva, Dariga
   Dudinskaya, Ekaterina
   Vygodin, Vladimir
   Skvortsov, Dmitry
   Nilsson, Peter
TI Association of Insulin Resistance, Arterial Stiffness and Telomere
   Length in Adults Free of Cardiovascular Diseases
SO PLOS ONE
LA English
DT Article
ID PULSE-WAVE VELOCITY; AORTIC STIFFNESS; METABOLIC SYNDROME; OXIDATIVE
   STRESS; RISK; GLUCOSE; MORTALITY; CELLS; MEN
AB Background
   Chronic inflammation and oxidative stress might be considered the key mechanisms of aging. Insulin resistance (IR) is a phenomenon related to inflammatory and oxidative stress. We tested the hypothesis that IR may be associated with cellular senescence, as measured by leukocyte telomere length (LTL), and arterial stiffness (core feature of arterial aging), as measured by carotid-femoral pulse wave velocity (c-f PWV).
   Methods
   The study group included 303 subjects, mean age 51.8 +/- 13.3 years, free of known cardiovascular diseases and regular drug consumption. For each patient, blood pressure was measured, blood samples were available for biochemical parameters, and LTL was analyzed by real time q PCR. C-f PWV was measured with the help of SphygmoCor. SAS 9.1 was used for statistical analysis.
   Results
   Through multiple linear regression analysis, c-f PWV is independently and positively associated with age (p = 0.0001) and the homeostasis model assessment of insulin resistance (HOMA-IR; p = 0.0001) and independently negatively associated with LTL (p = 0.0378). HOMA-IR seems to have a stronger influence than SBP on arterial stiffness. In all subjects, age, HOMA-IR, LTL, and SBP predicted 32% of the variance in c-f PWV. LTL was inversely associated with HOMA-IR (p = 0.0001) and age (p = 0.0001). In all subjects, HOMA-IR, age, sex, and SBP predicted 16% of the variance in LTL.
   Conclusions
   These data suggest that IR is associated with cell senescence and arterial aging and could, therefore, become the main target in preventing accelerated arterial aging, besides blood pressure control. Research in telomere biology may reveal new ways of estimating cardiovascular aging and risk.
C1 [Strazhesko, Irina; Tkacheva, Olga; Akasheva, Dariga; Dudinskaya, Ekaterina] Natl Res Ctr Prevent Med, Dept Aging & Age Associated Dis Prevent, Moscow, Russia.
   [Boytsov, Sergey] Natl Res Ctr Prevent Med, Dept Clin Cardiol & Mol Genet, Moscow, Russia.
   [Vygodin, Vladimir] Natl Res Ctr Prevent Med, Dept Epidemiol Chron Noncommunicable Dis, Lab Biostat, Moscow, Russia.
   [Skvortsov, Dmitry] Moscow MV Lomonosov State Univ, Dept Chem, Moscow, Russia.
   [Nilsson, Peter] Lund Univ, Skane Univ Hosp, Dept Clin Sci, Malmo, Sweden.
C3 National Medical Research Center for Therapy & Preventive Medicine;
   National Medical Research Center for Therapy & Preventive Medicine;
   National Medical Research Center for Therapy & Preventive Medicine;
   Lomonosov Moscow State University; Lund University; Skane University
   Hospital
RP Strazhesko, I (corresponding author), Natl Res Ctr Prevent Med, Dept Aging & Age Associated Dis Prevent, Moscow, Russia.
EM istrazhesko@gmail.com
RI Vygodin, Vladimir/AAB-9620-2020; Skvortsov, Dmitry/D-3738-2015;
   Strazhesko, Irina/AAD-9390-2019; Akasheva, Dariga/K-2764-2017; Tkacheva,
   Olga N./M-4510-2014; Drapkina, Oksana/G-8443-2016; Boytsov,
   Sergey/M-4486-2014; Dudinskaya, Ekaterina/H-3281-2013
OI Tkacheva, Olga N./0000-0002-4193-688X; Drapkina,
   Oksana/0000-0002-4453-8430; Boytsov, Sergey/0000-0001-6998-8406;
   Dudinskaya, Ekaterina/0000-0001-7891-6850; Skvortsov,
   Dmitry/0000-0001-8336-8596; Venkatasubramanian,
   Siddharth/0000-0002-5860-0768
FU Ministry of Health of Russian Federation
FX Funding provided by State task of Ministry of Health of Russian
   Federation. The funders had no role in study design, data collection and
   analysis, decision to publish, or preparation of the manuscript.
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NR 36
TC 34
Z9 40
U1 0
U2 19
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD AUG 26
PY 2015
VL 10
IS 8
AR e0136676
DI 10.1371/journal.pone.0136676
PG 12
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA CP7LO
UT WOS:000360069400150
PM 26308091
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Yoshida, M
   Tomiyama, H
   Yamada, J
   Koji, Y
   Shiina, K
   Nagata, M
   Yamashina, A
AF Yoshida, Masanobu
   Tomiyama, Hirofumi
   Yamada, Jiko
   Koji, Yutaka
   Shiina, Kazuki
   Nagata, Mikio
   Yamashina, Akira
TI Relationships among renal function loss within the normal to mildly
   impaired range, arterial stiffness, inflammation, and oxidative stress
SO CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
LA English
DT Article
ID CHRONIC KIDNEY-DISEASE; PULSE-WAVE VELOCITY; BLOOD-PRESSURE RESEARCH;
   C-REACTIVE PROTEIN; CARDIOVASCULAR MORTALITY; AORTIC STIFFNESS;
   ESSENTIAL-HYPERTENSION; CREATININE CLEARANCE; METABOLIC SYNDROME; SERUM
   CREATININE
AB Background and objectives: This study was conducted to clarify whether individuals with mildly impaired renal function show increased arterial stiffness, microinflammation, and oxidative stress as compared with those with normal renal function and also to examine the association of these parameters with the degree of GFR loss in middle-aged Japanese men with a low cardiovascular risk.
   Design, setting, participants, & measurements: The brachial-ankle pulse wave velocity and plasma levels of C-reactive protein and lipid peroxides were measured in 1873 men (42 +/- 9 yr of age).
   Results: The brachial-ankle pulse wave velocity but not the plasma C-reactive protein or lipid peroxides, was increased in individuals with mildly impaired renal function. The GFR was significantly correlated with the brachial-ankle pulse wave velocity but not with the log-transformed values of C-reactive protein or lipid peroxides. Multivariate linear regression analysis demonstrated a significant relationship between the brachial-ankle pulse wave velocity and the GFR, independent of the conventional atherosclerotic risk factors. This relationship was significant even in individuals with GFR values within the "normal renal function" range. Thus, GFR loss seems to be more closely associated with arterial stiffness than with microinflammation and/or oxidative stress.
   Conclusions: A weak but significant relationship was observed between the degree of GFR loss and arterial stiffness, even in individuals with GFR values within the normal renal function range. Therefore, increased arterial stiffness may underlie, at least in part, the elevated cardiovascular risk in individuals with mildly impaired renal function.
C1 Tokyo Med Univ, Dept Internal Med 2, Tokyo, Japan.
   Kajima Corp, Hlth Care Ctr, Tokyo, Japan.
C3 Tokyo Medical University; Kajima Corporation
RP Tomiyama, H (corresponding author), Tokyo Med Univ, Dept Internal Med 2, 6-7-1 Nishi Shinjuku, Tokyo, Japan.
EM tomiyama@tokyo-med.ac.jp
OI Shiina, Kazuki/0000-0002-7293-2064
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NR 36
TC 31
Z9 34
U1 0
U2 1
PU AMER SOC NEPHROLOGY
PI WASHINGTON
PA 1725 I ST, NW STE 510, WASHINGTON, DC 20006 USA
SN 1555-9041
EI 1555-905X
J9 CLIN J AM SOC NEPHRO
JI Clin. J. Am. Soc. Nephrol.
PD NOV
PY 2007
VL 2
IS 6
BP 1118
EP 1124
DI 10.2215/CJN.01880507
PG 7
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 225TC
UT WOS:000250539400008
PM 17913969
OA Bronze
DA 2025-06-11
ER

PT J
AU Wang, XL
   Wang, Z
   Liu, D
   Jiang, H
   Cai, C
   Li, GY
   Yu, GL
AF Wang, Xueliang
   Wang, Zhe
   Liu, Di
   Jiang, Hao
   Cai, Chao
   Li, Guoyun
   Yu, Guangli
TI Canagliflozin Prevents Lipid Accumulation, Mitochondrial Dysfunction,
   and Gut Microbiota Dysbiosis in Mice With Diabetic Cardiovascular
   Disease
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Article
DE canagliflozin; mitochondrion; hypolipidemic; colonic microbiota;
   myocardial protection; diabetic cardiovascular disease
ID LOW-GRADE INFLAMMATION; ENDOTHELIAL DYSFUNCTION; OXIDATIVE STRESS;
   SCIENTIFIC STATEMENT; INSULIN-RESISTANCE; METABOLIC SYNDROME; GLYCEMIC
   CONTROL; SOLUBLE CD40L; HIGH-FAT; TYPE-2
AB Type 2 diabetes mellitus (T2DM) is associated with cardiovascular disease (CVD) and sodium glucose cotransporter 2 inhibitors, as oral medications for T2DM treatment have shown the potential to improve vascular dysfunction. The aim of this study was to evaluate the ability of canagliflozin (Cana) to relieve CVD in T2DM mice and its possible action mechanism. Mice with diabetic CVD was conducted by a high-fat diet for 24 weeks, followed by oral gavaging with metformin (200 mg/kg/day) or Cana (50 mg/kg/day) for 6 weeks. The result demonstrated that Cana reduced serum lipid accumulation, and decreased the arteriosclerosis index and atherogenic index of plasma. In addition, Cana treatment reduced the circulating markers of inflammation. More importantly, Cana improved cardiac mitochondrial homeostasis and relieved oxidative stress. Moreover, Cana treatment alleviated the myocardial injury with decreasing levels of serous soluble cluster of differentiation 40 ligand and cardiac troponin I. Thus, cardiovascular abnormality was relieved by suppressing fibrosis and basement membrane thickening, while elevating the cluster of differentiation 31 expression level. Importantly, Cana increased the ratio of gut bacteria Firmicutes/Bacteroidetes and the relative abundance of Alistipes, Olsenella, and Alloprevotella, while it decreased the abundance of Mucispirillum, Helicobacter, and Proteobacteria at various taxonomic levels in mice with diabetic CVD. In short, Cana treatment altered the colonic microbiota composition close to the normal level, which was related with blood lipid, inflammation, and oxidative stress, and might play a vital role in CVD. In general, the improvements in the gut microbiota and myocardial mitochondrial homeostasis may represent the mechanism of Cana on CVD treatment.
C1 [Wang, Xueliang; Wang, Zhe; Liu, Di; Jiang, Hao; Cai, Chao; Li, Guoyun; Yu, Guangli] Ocean Univ China, Sch Med & Pharm, Shandong Prov Key Lab Glycosci & Glycotechnol, Key Lab Marine Drugs,Minist Educ, Qingdao, Peoples R China.
   [Wang, Xueliang] Sun Yat Sen Univ, Affiliated Hosp 1, Precis Med Inst, Guangzhou, Peoples R China.
   [Jiang, Hao; Cai, Chao; Li, Guoyun; Yu, Guangli] Pilot Natl Lab Marine Sci & Technol, Lab Marine Drugs & Bioprod, Qingdao, Peoples R China.
C3 Ministry of Education - China; Ocean University of China; Sun Yat Sen
   University; Laoshan Laboratory
RP Wang, XL; Jiang, H; Yu, GL (corresponding author), Ocean Univ China, Sch Med & Pharm, Shandong Prov Key Lab Glycosci & Glycotechnol, Key Lab Marine Drugs,Minist Educ, Qingdao, Peoples R China.; Wang, XL (corresponding author), Sun Yat Sen Univ, Affiliated Hosp 1, Precis Med Inst, Guangzhou, Peoples R China.; Jiang, H; Yu, GL (corresponding author), Pilot Natl Lab Marine Sci & Technol, Lab Marine Drugs & Bioprod, Qingdao, Peoples R China.
EM haojiang@ouc.edu.cn; glyu@ouc.edu.cn
RI Wang, Xueliang/AAY-7112-2021; Liu, DI/J-5448-2019; zhang,
   chenhong/HCH-9822-2022; Jiang, Hao/AAL-2019-2020
FU National Natural Science Foundation of China [81991522, 81402982,
   21807094]; National Science and Technology Major Project of China
   [2018ZX09735-004]; Shandong Provincial Major Science and Technology
   Innovation Project [2018SDKJ0404]; Taishan Scholar Climbing Project
   [TSPD20210304]; China Postdoctoral Science Foundation [2021M703684];
   Fundamental Research Funds for the Central Universities [202042005];
   Natural Science Foundation of Shandong Province [ZR2017BC007]
FX Funding This work was supported by the National Natural Science
   Foundation of China (81991522, 81402982, 21807094), National Science and
   Technology Major Project of China (2018ZX09735-004), Shandong Provincial
   Major Science and Technology Innovation Project (2018SDKJ0404), Taishan
   Scholar Climbing Project (TSPD20210304), Project funded by the China
   Postdoctoral Science Foundation (2021M703684), Fundamental Research
   Funds for the Central Universities (202042005), and Natural Science
   Foundation of Shandong Province (ZR2017BC007).
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NR 87
TC 18
Z9 19
U1 5
U2 40
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD FEB 23
PY 2022
VL 13
AR 839640
DI 10.3389/fphar.2022.839640
PG 16
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA ZQ2AD
UT WOS:000766912100001
PM 35281938
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Dludla, PV
   Nkambule, BB
   Mazibuko-Mbeje, SE
   Nyambuya, TM
   Marcheggiani, F
   Cirilli, I
   Ziqubu, K
   Shabalala, SC
   Johnson, R
   Louw, J
   Damiani, E
   Tiano, L
AF Dludla, Phiwayinkosi, V
   Nkambule, Bongani B.
   Mazibuko-Mbeje, Sithandiwe E.
   Nyambuya, Tawanda M.
   Marcheggiani, Fabio
   Cirilli, Ilenia
   Ziqubu, Khanyisani
   Shabalala, Samukelisiwe C.
   Johnson, Rabia
   Louw, Johan
   Damiani, Elisabetta
   Tiano, Luca
TI N-Acetyl Cysteine Targets Hepatic Lipid Accumulation to Curb Oxidative
   Stress and Inflammation in NAFLD: A Comprehensive Analysis of the
   Literature
SO ANTIOXIDANTS
LA English
DT Review
DE N-acetyl cysteine; antioxidants; non-alcoholic fatty liver disease;
   hepatic lipid accumulation; inflammation; oxidative stress
ID FATTY LIVER-DISEASE; ISCHEMIA-REPERFUSION INJURY; NONALCOHOLIC
   STEATOHEPATITIS; ACETYLCYSTEINE IMPROVES; URSODEOXYCHOLIC ACID;
   MONOCLONAL-ANTIBODY; MICE; RATS; CONSEQUENCES; CHOLESTEROL
AB Impaired adipose tissue function and insulin resistance remain instrumental in promoting hepatic lipid accumulation in conditions of metabolic syndrome. In fact, enhanced lipid accumulation together with oxidative stress and an abnormal inflammatory response underpin the development and severity of non-alcoholic fatty liver disease (NAFLD). There are currently no specific protective drugs against NAFLD, and effective interventions involving regular exercise and healthy diets have proved difficult to achieve and maintain. Alternatively, due to its antioxidant and anti-inflammatory properties, there has been growing interest in understanding the therapeutic effects of N-acetyl cysteine (NAC) against metabolic complications, including NAFLD. Here, reviewed evidence suggests that NAC blocks hepatic lipid accumulation in preclinical models of NAFLD. This is in part through the effective regulation of a fatty acid scavenger molecule (CD36) and transcriptional factors such as sterol regulatory element-binding protein (SREBP)-1c/-2 and peroxisome proliferator-activated receptor gamma (PPAR gamma). Importantly, NAC appears effective in improving liver function by reducing pro-inflammatory markers such as interleukin (IL)-6 IL-1 beta, tumour necrosis factor alpha (TNF-alpha) and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappa B). This was primarily through the attenuation of lipid peroxidation and enhancements in intracellular response antioxidants, particularly glutathione. Very few clinical studies support the beneficial effects of NAC against NAFLD-related complications, thus well-organized randomized clinical trials are still necessary to confirm its therapeutic potential.
C1 [Dludla, Phiwayinkosi, V; Shabalala, Samukelisiwe C.; Johnson, Rabia; Louw, Johan] South African Med Res Council, Biomed Res & Innovat Platform, ZA-7505 Tygerberg, South Africa.
   [Dludla, Phiwayinkosi, V; Marcheggiani, Fabio; Cirilli, Ilenia; Damiani, Elisabetta; Tiano, Luca] Polytech Univ Marche, Dept Life & Environm Sci, I-60131 Ancona, Italy.
   [Nkambule, Bongani B.; Nyambuya, Tawanda M.] Univ KwaZulu Natal, Coll Hlth Sci, Sch Lab Med & Med Sci, ZA-4000 Durban, South Africa.
   [Mazibuko-Mbeje, Sithandiwe E.; Ziqubu, Khanyisani] North West Univ, Fac Nat & Agr Sci, Dept Biochem, ZA-2745 Mmabatho, South Africa.
   [Nyambuya, Tawanda M.] Namibia Univ Sci & Technol, Fac Hlth & Appl Sci, Dept Hlth Sci, Windhoek 9000, Namibia.
   [Cirilli, Ilenia] Univ Camerino, Sch Pharm, I-62032 Camerino, Italy.
   [Shabalala, Samukelisiwe C.; Louw, Johan] Univ Zululand, Dept Biochem & Microbiol, ZA-3880 Kwa Dlangezwa, South Africa.
   [Johnson, Rabia] Stellenbosch Univ, Fac Hlth Sci, Div Med Physiol, ZA-7505 Tygerberg, South Africa.
C3 South African Medical Research Council; Marche Polytechnic University;
   University of Kwazulu Natal; North West University - South Africa;
   Namibia University of Science & Technology; University of Camerino;
   University of Zululand; Stellenbosch University
RP Dludla, PV (corresponding author), South African Med Res Council, Biomed Res & Innovat Platform, ZA-7505 Tygerberg, South Africa.; Dludla, PV (corresponding author), Polytech Univ Marche, Dept Life & Environm Sci, I-60131 Ancona, Italy.
EM pdludla@mrc.ac.za; nkambuleb@ukzn.ac.za; 36588296@nwu.ac.za;
   mnyambuya@nust.na; f.marcheggiani@univpm.it; ilenia.cirilli@unicam.it;
   ziqubukhanyisani@gmail.com; samukelisiwe.shabalala@mrc.ac.za;
   rabia.johnson@mrc.ac.za; johan.louw@mrc.ac.za; e.damiani@univpm.it;
   l.tiano@univpm.it
RI Damiani, Elisabetta/JVZ-2087-2024; Mazibuko-Mbeje,
   Sithandiwe/HPG-1119-2023; Johnson, Rabia/ADW-4478-2022; Nyambuya,
   Tawanda Maurice/GLU-4124-2022; Tiano, Luca/ABC-2341-2020; Nkambule,
   Bongani/ABD-7943-2022
OI Nyambuya, Tawanda Maurice/0000-0002-3288-9524; Damiani,
   Elisabetta/0000-0002-7885-1783; Marcheggiani, Fabio/0000-0002-3272-7525;
   Cirilli, Ilenia/0000-0001-6916-5426; Shabalala,
   Samukelisiwe/0000-0003-1238-4673; Nkambule, Bongani/0000-0001-8846-1992;
   Dludla, Phiwayinkosi/0000-0001-5965-3610; Tiano,
   Luca/0000-0002-7519-7106; Johnson, Rabia/0000-0002-6328-0789
FU Biomedical Research and Innovation Platform of the South African Medical
   Research Council (SAMRC); National Research Foundation [117829]; SAMRC
   through its division of Research Capacity Development; South African
   Treasury
FX This research was funded in part by baseline funding from the Biomedical
   Research and Innovation Platform of the South African Medical Research
   Council (SAMRC) and the National Research Foundation (Grant number:
   117829). P.V.D. was partially supported as a Post-Doctoral Fellow by
   funding from the SAMRC through its division of Research Capacity
   Development under the Intra-Mural Postdoctoral Fellowship Programme from
   funding received from the South African Treasury. The content hereof is
   the sole responsibility of the authors and does not necessarily
   represent the official views of the SAMRC or the funders.
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NR 87
TC 48
Z9 52
U1 2
U2 17
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD DEC
PY 2020
VL 9
IS 12
AR 1283
DI 10.3390/antiox9121283
PG 20
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA PJ4KV
UT WOS:000601739700001
PM 33339155
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Alkholy, UM
   Abdalmonem, N
   Zaki, A
   Elkoumi, MA
   Abu Hashim, MI
   Basset, MAA
   Salah, HE
AF Alkholy, Usama M.
   Abdalmonem, Nermin
   Zaki, Ahmed
   Elkoumi, Mohamed A.
   Abu Hashim, Mustafa, I
   Basset, Maha A. A.
   Salah, Hossam E.
TI The antioxidant status of coenzyme Q10 and vitamin E in children with
   type 1 diabetes
SO JORNAL DE PEDIATRIA
LA English
DT Article
DE Type 1 diabetes; Oxidative stress; Vitamin E; Coenzyme Q10
ID OXIDATIVE STRESS; METABOLIC SYNDROME; PLASMA-LEVELS; REDOX STATUS;
   BLOOD-CELLS; SUPPLEMENTATION; ADOLESCENTS; MELLITUS; INDIVIDUALS;
   CAPACITY
AB Objective: The purpose of this study was to evaluate the antioxidant status of plasma vitamin E and plasma and intracellular coenzyme Q10 in children with type 1 diabetes.
   Method: This case-control study was conducted on 72 children with type 1 diabetes and compared to 48 healthy children, who were age, sex, and ethnicity-matched. The diabetic children were divided according to their glycosylated hemoglobin (A1c %) into two groups: poor and good glycemic control groups. All children underwent full history taking, clinical examination, and laboratory measurement of complete blood count, A1c %, plasma cholesterol, triglycerides, and vitamin E levels and coenzyme Q10 levels in plasma, erythrocytes, and platelets.
   Results: Children with poor glycemic control showed significantly higher plasma vitamin E, coenzyme Q10, triglycerides, low-density lipoproteins, waist circumference/height ratio, cholesterol levels, and tower high-density lipoproteins and platelet coenzyme Q10 redox status in comparison to those with good glycemic control and the control group (p <0.05). Plasma coenzyme Q10 showed a positive correlation with the duration of type 1 diabetes, triglycerides, cholesterol, vitamin E, and A1c %, and negative correlation with the age of the diabetic group (p< 0.05). The platelet redox status showed a negative correlation with the A1c % levels (r= -0.31; p= 0.022) and the duration of type 1 diabetes (r= -0.35, p= 0.012).
   Conclusion: Patients with type 1 diabetes, especially poorly controlled, had elevation of plasma vitamin E and coenzyme Q10 levels and decreased platelet redox status of coenzyme Q10, which may be an indicator of increased oxidative stress. (C) 2018 Sociedade Brasiteira de Pediatria. Published by Elsevier Editora Ltda.
C1 [Alkholy, Usama M.; Abdalmonem, Nermin; Elkoumi, Mohamed A.; Abu Hashim, Mustafa, I; Basset, Maha A. A.] Zagazig Univ, Fac Med, Pediat Dept, Sharkia, Egypt.
   [Zaki, Ahmed] Mansoura Univ, Fac Med, Pediat Dept, Mansoura, Egypt.
   [Salah, Hossam E.] Zagazig Univ, Fac Med, Clin Pathol Dept, Sharkia, Egypt.
C3 Egyptian Knowledge Bank (EKB); Zagazig University; Egyptian Knowledge
   Bank (EKB); Mansoura University; Egyptian Knowledge Bank (EKB); Zagazig
   University
RP Alkholy, UM (corresponding author), Zagazig Univ, Fac Med, Pediat Dept, Sharkia, Egypt.
EM usamaalkoly@yahoo.com
RI /R-8962-2018
OI Hassan, Ahmed Zaki Mohammed/0000-0001-6359-5572
CR [Anonymous], 2012, SULTAN QABOOS U MED, DOI DOI 10.12816/0003082
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NR 30
TC 11
Z9 11
U1 0
U2 6
PU SOC BRASIL PEDIATRIA
PI RIO DE JANEIRO, RJ
PA RUA SANTA CLARA 292, RIO DE JANEIRO, RJ, CEP 22401-01, BRAZIL
SN 0021-7557
EI 1678-4782
J9 J PEDIAT-BRAZIL
JI J. Pediatr.
PD MAR-APR
PY 2019
VL 95
IS 2
BP 224
EP 230
DI 10.1016/j.jped.2017.12.005
PG 7
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA HS9EU
UT WOS:000464171400013
PM 29425798
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Pinto, BAS
   Melo, TM
   Flister, KFT
   França, LM
   Kajihara, D
   Tanaka, LY
   Laurindo, FRM
   Paes, AMD
AF Serra Pinto, Bruno Araujo
   Melo, Thamys Marinho
   Torres Flister, Karla Frida
   Franca, Lucas Martins
   Kajihara, Daniela
   Tanaka, Leonardo Yuji
   Martins Laurindo, Francisco Rafael
   de Andrade Paes, Antonio Marcus
TI Early and sustained exposure to high-sucrose diet triggers hippocampal
   ER stress in young rats
SO METABOLIC BRAIN DISEASE
LA English
DT Article
DE High-sucrose diet; Metabolic syndrome; Hippocampus; Unfolded protein
   response; Neurological impairment; Developmental origins of health and
   disease
ID ENDOPLASMIC-RETICULUM STRESS; FRUCTOSE CORN SYRUP; ADIPOSE-TISSUE;
   BODY-WEIGHT; GLUCOSE; OBESITY; TRIGLYCERIDES; SUGAR; INDEX; ACCUMULATION
AB Early-life environmental insults have been shown to promote long-term development of chronic non-communicable diseases, including metabolic disturbances and mental illnesses. As such, premature consumption of high-sugar foods has been associated to early onset of detrimental outcomes, whereas underlying mechanisms are still poorly understood. In the present study, we sought to investigate whether early and sustained exposure to high-sucrose diet promotes metabolic disturbances that ultimately might anticipate neurological injuries. At postnatal day 21, weaned male rats started to be fed a standard chow (10 % sucrose, CTR) or a high-sucrose diet (25 % sucrose, HSD) for 9 weeks prior to euthanasia at postnatal day 90. HSD did not alter weight gain and feed efficiency between groups, but increased visceral, non-visceral and brown adipose tissue accumulation. HSD rats demonstrated elevated blood glucose levels in both fasting and fed states, which were associated to impaired glucose tolerance. Peripheral insulin sensitivity did not change, whereas hepatic insulin resistance was supported by increased serum triglyceride levels, as well as higher TyG index values. Assessment of hippocampal gene expression showed endoplasmic reticulum (ER) stress pathways were activated in HSD rats, as compared to CTR. HSD rats had overexpression of unfolded protein response sensors, PERK and ATF6; ER chaperone, PDIA2 and apoptosis-related genes, CHOP and Caspase 3; but decreased expression of chaperone GRP78. Finally, HSD rats demonstrated impaired neuromuscular function and anxious behavior, but preserved cognitive parameters. In conclusion, our data indicate that early exposure to HSD promote metabolic disturbances, which disrupt hippocampus homeostasis and might precociously affect its neurobehavioral functions.
C1 [Serra Pinto, Bruno Araujo; Melo, Thamys Marinho; Torres Flister, Karla Frida; Franca, Lucas Martins; de Andrade Paes, Antonio Marcus] Univ Fed Maranhao, Dept Physiol Sci, Lab Expt Physiol, Sao Luis, Maranhao, Brazil.
   [Kajihara, Daniela; Tanaka, Leonardo Yuji; Martins Laurindo, Francisco Rafael] Univ Sao Paulo, Sch Med, Inst Heart, Lab Vasc Biol, Sao Paulo, SP, Brazil.
C3 Universidade Federal do Maranhao; Universidade de Sao Paulo
RP Paes, AMD (corresponding author), Univ Fed Maranhao, Dept Physiol Sci, Lab Expt Physiol, Sao Luis, Maranhao, Brazil.
EM marcuspaes@ufma.br
RI Kajihara, Daniela/AAR-1172-2020; Tanaka, Leonardo/H-9832-2013; França,
   Lucas/IAM-5986-2023; Laurindo, Francisco/J-6575-2015; Paes,
   Antonio/C-7174-2013
OI Laurindo, Francisco/0000-0001-6837-4509; Kajihara,
   Daniela/0000-0001-9239-4198; Martins Franca, Lucas/0000-0002-4412-1539
FU Fundacao de Amparo a Pesquisa e ao Desenvolvimento Cientifico e
   Tecnologico do Maranhao - FAPEMA [PAEDT-00380/14, UNIVERSAL-00523/14,
   UNIVERSAL-00792/14]; Conselho Nacional de Desenvolvimento Cientifico e
   Tecnologico - CNPq
FX Authors are thankful to the LeFisio's staff for all the technical
   support during experimental procedures, especially to Caroline Vale,
   Danylo Noleto and Pamela Santos. This work was funded by Fundacao de
   Amparo a Pesquisa e ao Desenvolvimento Cientifico e Tecnologico do
   Maranhao - FAPEMA through the grants PAEDT-00380/14, UNIVERSAL-00523/14,
   and UNIVERSAL-00792/14. TMM received fellowship from Conselho Nacional
   de Desenvolvimento Cientifico e Tecnologico - CNPq.
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   Zhao YM, 2015, BRAIN RES BULL, V111, P27, DOI 10.1016/j.brainresbull.2014.12.006
NR 60
TC 30
Z9 34
U1 0
U2 23
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0885-7490
EI 1573-7365
J9 METAB BRAIN DIS
JI Metab. Brain Dis.
PD AUG
PY 2016
VL 31
IS 4
BP 917
EP 927
DI 10.1007/s11011-016-9830-1
PG 11
WC Endocrinology & Metabolism; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology
GA DQ4QH
UT WOS:000379187900021
PM 27154727
DA 2025-06-11
ER

PT J
AU Justo, ML
   Candiracci, M
   Dantas, AP
   de Sotomayor, MA
   Parrado, J
   Vila, E
   Herrera, MD
   Rodriguez-Rodriguez, R
AF Luisa Justo, Maria
   Candiracci, Manila
   Paula Dantas, Ana
   Alvarez de Sotomayor, Maria
   Parrado, Juan
   Vila, Elisabet
   Dolores Herrera, Maria
   Rodriguez-Rodriguez, Rosalia
TI Rice bran enzymatic extract restores endothelial function and vascular
   contractility in obese rats, by reducing vascular inflammation and
   oxidative stress
SO JOURNAL OF NUTRITIONAL BIOCHEMISTRY
LA English
DT Article
DE Obesity; Rice bran; Vascular dysfunction; Vascular inflammation;
   Vascular oxidative stress
ID ANTIOXIDANT ACTIVITY; METABOLIC SYNDROME; ANGIOTENSIN-II; BLOOD-VESSELS;
   FERULIC ACID; HYPERTENSION; ORYZANOL; SUPPRESSION; PERFUSION; OIL
AB Background: Rice bran enzymatic extract (RBEE) used in this study has shown beneficial activities against dyslipidemia, hyperinsulinemia and hypertension. Our aim was to investigate the effects of a diet supplemented with RBEE in vascular impairment developed in obese Zucker rats and to evaluate the main mechanisms mediating this action.
   Methods and results: Obese Zucker rats were fed a 1% and 5% RBEE-supplemented diet (O1% and O5%). Obese and their lean littermates fed a standard diet were used as controls (OC and LC, respectively). Vascular function was evaluated in aortic rings in organ baths. The role of nitric oxide (NO) was investigated by using NO synthase (NOS) inhibitors. Aortic expression of endothelial NOS (eNOS), inducible NOS (iNOS), tumor necrosis factor (TNF)-alpha and nicotinamide adenine dinucleotide phosphate (NADPH) oxidase subunits and superoxide production in arterial wall were determined. Endothelial dysfunction and vascular hyperreactivity to phenylephrine in obese rats were ameliorated by RBEE treatment, particularly with 1% RBEE. Up-regulation of eNOS protein expression in RBEE-treated aortas should contribute to this activity. RBEE attenuated vascular inflammation by reducing aortic iNOS and TNF-alpha expression. Aortas from RBEE-treated groups showed a significant decrease of superoxide production and down-regulation of NADPH oxidase subunits.
   Conclusion: RBEE treatment restored endothelial function and vascular contractility in obese Zucker rats through a reduction of vascular inflammation and oxidative stress. These results show the nutraceutical potential of RBEE to prevent obesity-related vascular complications. (C) 2013 Elsevier Inc. All rights reserved.
C1 [Luisa Justo, Maria; Alvarez de Sotomayor, Maria; Dolores Herrera, Maria; Rodriguez-Rodriguez, Rosalia] Univ Seville, Dept Pharmacol, Sch Pharm, E-41012 Seville, Spain.
   [Candiracci, Manila; Parrado, Juan] Univ Seville, Dept Biochem & Mol Biol, Sch Pharm, E-41012 Seville, Spain.
   [Paula Dantas, Ana] Inst Invest Biomed August Pi & Sunyer IDIBAPS, Barcelona, Spain.
   [Vila, Elisabet] Univ Autonoma Barcelona, Fac Med, Dept Farmacol Terapeut & Toxicol, Inst Neurociencies, E-08193 Barcelona, Spain.
C3 University of Sevilla; University of Sevilla; University of Barcelona;
   Hospital Clinic de Barcelona; IDIBAPS; University of Barcelona;
   Autonomous University of Barcelona
RP Rodriguez-Rodriguez, R (corresponding author), Univ Seville, Dept Pharmacol, Sch Pharm, C Prof Garcia Gonzalez 2, E-41012 Seville, Spain.
EM rodriguezr@us.es
RI Herrera, María/B-6373-2008; Parrado, Juan/E-6637-2010; Dantas, Ana
   Paula/I-4100-2015; Alvarez de Sotomayor Paz, Maria/A-3838-2008
OI Parrado, Juan/0000-0002-1462-408X; Dantas, Ana
   Paula/0000-0001-8514-4094; Rodriguez-Rodriguez,
   Rosalia/0000-0002-6908-7197; Herrera Gonzalez, Maria
   Dolores/0000-0001-7231-9537; Alvarez de Sotomayor Paz,
   Maria/0000-0001-8466-1698
FU Spanish Ministry of Science and Innovation [AGL2009-1159]; Spanish
   Government
FX This research was supported by The Spanish Ministry of Science and
   Innovation (AGL2009-1159). Justo M.L. has been a recipient of an FPU
   fellowship from the Spanish Government.
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NR 43
TC 46
Z9 47
U1 0
U2 35
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0955-2863
EI 1873-4847
J9 J NUTR BIOCHEM
JI J. Nutr. Biochem.
PD AUG
PY 2013
VL 24
IS 8
BP 1453
EP 1461
DI 10.1016/j.jnutbio.2012.12.004
PG 9
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA 189TB
UT WOS:000322290100006
PM 23465593
DA 2025-06-11
ER

PT J
AU Xn, D
   Wu, Y
   Liu, F
   Liu, YS
   Shen, L
   Lei, YY
   Liu, J
   Ping, J
   Qin, J
   Zhang, C
   Chen, LB
   Magdalou, J
   Wang, H
AF Xn, D.
   Wu, Y.
   Liu, F.
   Liu, Y. S.
   Shen, L.
   Lei, Y. Y.
   Liu, J.
   Ping, J.
   Qin, J.
   Zhang, C.
   Chen, L. B.
   Magdalou, J.
   Wang, H.
TI A hypothalamic-pituitary-adrenal axis-associated neuroendocrine
   metabolic programmed alteration in offspring rats of IUGR induced by
   prenatal caffeine ingestion
SO TOXICOLOGY AND APPLIED PHARMACOLOGY
LA English
DT Article
DE Caffeine; Intrauterine growth retardation; Glucocorticoid;
   Hypothalamic-pituitary-adrenal axis; Glucose and lipid metabolism
ID GLUCOCORTICOID-RECEPTOR; INSULIN SENSITIVITY; FETAL ORIGINS; ADULT-RATS;
   GROWTH; STRESS; BRAIN; EXPRESSION; EXPOSURE; OBESITY
AB Caffeine is a definite factor of intrauterine growth retardation (IUGR). Previously, we have confirmed that prenatal caffeine ingestion inhibits the development of hypothalamic-pituitary-adrenal (HPA) axis, and alters the glucose and lipid metabolism in IUGR fetal rats. In this study, we aimed to verify a programmed alteration of neuroendocrine metabolism in prenatal caffeine ingested-offspring rats. The results showed that prenatal caffeine (120 mg/kg.day) ingestion caused low body weight and high IUGR rate of pups: the concentrations of blood adrenocorticotropic hormone (ACTH) and corticosterone in caffeine group were significantly increased in the early postnatal period followed by falling in late stage; the level of blood glucose was unchanged, while blood total cholesterol (TCH) and triglyceride (TG) were markedly enhanced in adult. After chronic stress, the concentrations and the gain rates of blood ACTH and corticosterone were obviously increased, meanwhile, the blood glucose increased while the TCH and TG decreased in caffeine group. Further, the hippocampal mineralocorticoid receptor (MR) expression in caffeine group was initially decreased and subsequently increased after birth. After chronic stress, the 11 beta-hydroxysteroid dehydrogenase-1, glucocorticoid receptor (GR), MR as well as the MR/GR ratio were all significantly decreased. These results suggested that prenatal caffeine ingestion induced the dysfunction of HPA axis and associated neuroendocrine metabolic programmed alteration in IUGR offspring rats, which might be related with the functional injury of hippocampus. These observations provide a valuable experimental basis for explaining the susceptibility of IUGR offspring to metabolic syndrome and associated diseases. (c) 2012 Elsevier Inc. All rights reserved.
C1 [Xn, D.; Wu, Y.; Liu, F.; Liu, Y. S.; Shen, L.; Lei, Y. Y.; Liu, J.; Ping, J.; Zhang, C.; Wang, H.] Wuhan Univ, Basic Med Sch, Dept Pharmacol, Wuhan 430071, Hubei Province, Peoples R China.
   [Xn, D.; Ping, J.; Wang, H.] Wuhan Univ, Res Ctr Food & Drug Evaluat, Wuhan 430071, Peoples R China.
   [Qin, J.; Chen, L. B.] Wuhan Univ, Zhongnan Hosp, Dept Orthoped Surg, Wuhan 430071, Peoples R China.
   [Magdalou, J.] Nancy Univ, CNRS, UMR 7561, Fac Med, Vandoeuvre Les Nancy, France.
C3 Wuhan University; Wuhan University; Wuhan University; Universite de
   Lorraine; Centre National de la Recherche Scientifique (CNRS)
RP Wang, H (corresponding author), Wuhan Univ, Basic Med Sch, Dept Pharmacol, Wuhan 430071, Hubei Province, Peoples R China.
EM wanghui19@whu.edu.cn
FU National Natural Science Foundation of China [30830112, 81072709,
   81220108026, 81202240]; Key Grant Project of the Chinese Ministry of
   Education [V200801]; Hubei Province Science Foundation for Innovation
   Group [2009CDA079]; Key Grant of China [2001CDA042]
FX This work was supported by grants from the National Natural Science
   Foundation of China (Nos. 30830112, 81072709, 81220108026 and 81202240),
   the Key Grant Project of the Chinese Ministry of Education (No.
   V200801), the Hubei Province Science Foundation for Innovation Group
   (No. 2009CDA079) and for Key Grant (No. 2001CDA042) of China.
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NR 46
TC 70
Z9 80
U1 1
U2 21
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0041-008X
EI 1096-0333
J9 TOXICOL APPL PHARM
JI Toxicol. Appl. Pharmacol.
PD NOV 1
PY 2012
VL 264
IS 3
BP 395
EP 403
DI 10.1016/j.taap.2012.08.016
PG 9
WC Pharmacology & Pharmacy; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Toxicology
GA 031VG
UT WOS:000310670000011
PM 22959462
DA 2025-06-11
ER

PT J
AU Ferreira, IL
   Resende, R
   Ferreiro, E
   Rego, AC
   Pereira, CF
AF Ferreira, I. L.
   Resende, R.
   Ferreiro, E.
   Rego, A. C.
   Pereira, C. F.
TI Multiple Defects in Energy Metabolism in Alzheimer's Disease
SO CURRENT DRUG TARGETS
LA English
DT Review
DE Alzheimer's disease; glucose metabolism; mitochondria; glutamate
   receptors; endoplasmic reticulum; calcium
ID AMYLOID-BETA-PEPTIDE; ENDOPLASMIC-RETICULUM STRESS;
   CYTOCHROME-C-OXIDASE; ABNORMAL MITOCHONDRIAL DYNAMICS; UNFOLDED PROTEIN
   RESPONSE; TRANSGENIC MOUSE MODEL; A-BETA; OXIDATIVE STRESS; CELL-DEATH;
   ER STRESS
AB Alzheimer's disease (AD) is the most common form of dementia in old age. Cognitive impairment in AD may be partially due to overall hypometabolism. Indeed, AD is characterized by an early region-specific decline in glucose utilization and by mitochondrial dysfunction, which have deleterious consequences for neurons through increased production of reactive oxygen species (ROS), ATP depletion and activation of cell death processes. In this article, we provide an overview of the alterations on energetic metabolism occurring in AD. First, we resume the evidences that link the 'metabolic syndrome' with increased risk for developing AD and revisit the major changes occurring on both extramitochondrial and mitochondrial metabolic pathways, as revealed by imaging studies and biochemical analysis of brain and peripheral samples obtained from AD patients. We also cover the recent findings on cellular and animal models that highlight mitochondrial dysfunction as a fundamental mechanism in AD pathogenesis. Recent evidence posits that mitochondrial abnormalities in this neurodegenerative disorder are associated with changes in mitochondrial dynamics and can be induced by amyloid-beta (A beta) that progressively accumulates within this organelle, acting as a direct toxin. Furthermore, A beta induces activation of glutamate N-methyl-D-aspartate receptors (NMDARs) and/or excessive release of calcium from endoplasmic reticulum (ER) that may underlie mitochondrial calcium dyshomeostasis thereby disturbing organelle functioning and, ultimately, damaging neurons. Throughout the review, we further discuss several therapeutic strategies aimed to restore neuronal metabolic function in cellular and animal models of AD, some of which have reached the stage of clinical trials.
C1 [Ferreira, I. L.; Resende, R.; Ferreiro, E.; Rego, A. C.; Pereira, C. F.] Univ Coimbra, Ctr Neurosci & Cell Biol, P-3004517 Coimbra, Portugal.
   [Rego, A. C.; Pereira, C. F.] Univ Coimbra, Fac Med, P-3004517 Coimbra, Portugal.
C3 Universidade de Coimbra; Universidade de Coimbra
RP Pereira, CF (corresponding author), Univ Coimbra, Ctr Neurosci & Cell Biol, P-3004517 Coimbra, Portugal.
EM claudia.mf.pereira@gmail.com
RI Ferreira, I./A-6443-2011; Rego, Ana/AAH-2606-2020; Resende,
   Rosa/F-4610-2010; Ferreiro, Elisabete/D-1658-2011; Pereira, Claudia
   Maria Fragao/A-6506-2013; Rego, Ana Cristina/L-4272-2014
OI Resende, Rosa/0000-0002-0504-5756; Ferreiro,
   Elisabete/0000-0002-1200-4602; Pereira, Claudia Maria
   Fragao/0000-0002-6630-5056; Rego, Ana Cristina/0000-0003-0700-3776;
   Ferreira, Ildete/0000-0001-6552-4479
FU Fundacao para a Ciencia e a Tecnologia (FCT), Portugal
   [PTDC/SAU-NEU/71675/2006]; pharmaceutical company Lundbeck; Fundação
   para a Ciência e a Tecnologia [PTDC/SAU-NEU/71675/2006] Funding Source:
   FCT
FX The authors acknowledge financial support from Fundacao para a Ciencia e
   a Tecnologia (FCT), Portugal (project reference PTDC/SAU-NEU/71675/2006)
   and the pharmaceutical company Lundbeck.
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NR 197
TC 153
Z9 176
U1 1
U2 34
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1389-4501
EI 1873-5592
J9 CURR DRUG TARGETS
JI Curr. Drug Targets
PD OCT
PY 2010
VL 11
IS 10
BP 1193
EP 1206
PG 14
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 692VM
UT WOS:000285183900002
PM 20840064
DA 2025-06-11
ER

PT J
AU Lopresti, AL
   Smith, SJ
   Drummond, PD
AF Lopresti, Adrian L.
   Smith, Stephen J.
   Drummond, Peter D.
TI Modulation of the hypothalamic-pituitary-adrenal (HPA) axis by plants
   and phytonutrients: a systematic review of human trials
SO NUTRITIONAL NEUROSCIENCE
LA English
DT Review
DE Systematic review; herbs; spices; plants; phytonutrients; HPA-axis;
   cortisol; human trials
ID ASHWAGANDHA ROOT EXTRACT; DOUBLE-BLIND; METABOLIC SYNDROME; GRAPEFRUIT
   JUICE; STRESS SYSTEM; SOCIAL STRESS; ELEUTHEROCOCCUS-SENTICOSUS;
   CIMICIFUGA-RACEMOSA; RHODIOLA-ROSEA; RED GINSENG
AB Introduction
   The hypothalamic-pituitary-adrenal (HPA) axis plays a central role in the stress response. Plants, herbs, spices, and plant-based nutrients may influence HPA-axis activity.
   Objective
   To evaluate randomised controlled, human trials assessing the effects of single plants or phytonutrients on HPA-axis related hormones.
   Methods
   A systematic review of PubMed, Cochrane library, and the Cumulative Index to Nursing and Allied Health Literature was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Inclusion criteria comprised of human, randomised controlled studies with a control intervention examining the effects of a single herb, spice, plant, or extract on pre- and post-changes in blood, saliva, urine, or hair concentrations of cortisol, cortisone, corticotrophin-releasing hormone, or adrenocorticotropic hormone. Databases were searched from inception until October 2020.
   Results
   Fifty-two studies were identified examining the effects of ashwagandha, Korean ginseng, St John's Wort, cannabidiol, Rhodiola rosea, curcumin, cherry juice, asparagus, Jiaogulan, Black cohosh, Siberian ginseng, Bacopa monnieri, blueberries, green tea, Caralluma fimbriata, cashew apple juice, melon, American ginseng, Ginkgo biloba, grape juice, grapefruit juice, rosella, hops, mangosteen, holy basil, and pomegranate juice. Due to significant variability in study designs, the effect of phytonutrients on HPA-axis activity in humans was unclear. The most consistent finding was a morning, cortisol-lowering effect from ashwagandha supplementation.
   Conclusion
   For most phytonutrients, the effects of supplementation on HPA-axis activity in humans is unclear. Before more definitive conclusions about the effects of phytonutrients on the HPA-axis can be made, further research is required.
C1 [Lopresti, Adrian L.; Smith, Stephen J.] Clin Res Australia, 38 Arnisdale Rd Duncraig, Perth, WA 6023, Australia.
   [Lopresti, Adrian L.; Smith, Stephen J.; Drummond, Peter D.] Murdoch Univ, Coll Sci Hlth Engn & Educ, Perth, WA, Australia.
C3 Murdoch University
RP Lopresti, AL (corresponding author), Clin Res Australia, 38 Arnisdale Rd Duncraig, Perth, WA 6023, Australia.
EM adrian@clinicalresearch.com.au
OI Lopresti, Adrian/0000-0002-6409-7839
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NR 130
TC 17
Z9 17
U1 2
U2 29
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1028-415X
EI 1476-8305
J9 NUTR NEUROSCI
JI Nutr. Neurosci.
PD AUG 3
PY 2022
VL 25
IS 8
BP 1704
EP 1730
DI 10.1080/1028415X.2021.1892253
EA MAR 2021
PG 27
WC Neurosciences; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Nutrition & Dietetics
GA 3I2ZL
UT WOS:000624748600001
PM 33650944
DA 2025-06-11
ER

PT J
AU Rivera-Alvarez, I
   Pérez-Treviño, P
   Chapoy-Villanueva, H
   Vela-Guajardo, JE
   Nieblas, B
   Garza-González, S
   García-Rivas, G
   García, N
AF Rivera-Alvarez, Irais
   Perez-Trevino, Perla
   Chapoy-Villanueva, Hector
   Vela-Guajardo, Jorge E.
   Nieblas, Bianca
   Garza-Gonzalez, Salvador
   Garcia-Rivas, Gerardo
   Garcia, Noemi
TI A single session of physical activity restores the mitochondrial
   organization disrupted by obesity in skeletal muscle fibers
SO LIFE SCIENCES
LA English
DT Article
DE Mitochondrial dynamics; Metabolic syndrome; Oxidative stress; AMPK;
   Mitochondria quality control
ID ACTIVATED PROTEIN-KINASE; OXIDATIVE STRESS; SARCOPLASMIC-RETICULUM;
   MEDIATES MITOCHONDRIAL; AMPK ACTIVITY; FISSION; EXERCISE; FUSION; OPA1;
   EXPRESSION
AB Background: Several studies have proved that physical activity (PA) regulates energetic metabolism associated with mitochondrial dynamics through AMPK activation in healthy subjects. Obesity, a condition that induces oxidative stress, mitochondrial dysfunction, and low AMPK activity leads to mitochondrial fragmentation. However, few studies describe the effect of PA on mitochondrial dynamics regulation in obesity.
   Aim: The present study aimed to evaluate the effect of a single session of PA on mitochondrial dynamics regulation as well as its effect on mitochondrial function and organization in skeletal muscles of obese rats (Zucker fa/fa).
   Main methods: Male Zucker lean and Zucker fa/fa rats aged 12 to 13 weeks were divided into sedentary and subjected-to-PA (single session swimming) groups. Gastrocnemius muscle was dissected into isolated fibers, mitochondria, mRNA, and total proteins for their evaluation.
   Key findings: The results showed that PA increased the Mfn-2 protein level in the lean and obese groups, whereas Drp1 levels decreased in the obese group. OMA1 protease levels increased in the lean group and decreased in the obese group. Additionally, AMPK analysis parameters (expression, protein level, and activity) did not increase in the obese group. These findings correlated with the partial restoration of mitochondrial function in the obese group, increasing the capacity to maintain the membrane potential after adding calcium as a stressor, and increasing the transversal organization level of the mitochondria analyzed in isolated fibers.
   Significance: These results support the notion that obese rats subjected to PA maintain mitochondrial function through mitochondrial fusion activation by an AMPK-independent mechanism.
C1 [Rivera-Alvarez, Irais; Perez-Trevino, Perla; Chapoy-Villanueva, Hector; Vela-Guajardo, Jorge E.; Nieblas, Bianca; Garza-Gonzalez, Salvador; Garcia-Rivas, Gerardo; Garcia, Noemi] Tecnol Monterrey, Escuela Med & Ciencias Salud, San Pedro Garza Garcia, NL, Mexico.
   [Garcia-Rivas, Gerardo; Garcia, Noemi] Hosp Zambrano Hell, Ctr Invest Biomed, San Pedro Garza Garcia, NL, Mexico.
C3 Tecnologico de Monterrey; Tecnologico de Monterrey
RP García, N (corresponding author), Tecnol Monterrey, Hosp Zambrano Hell, Escuela Med & Ciencias Salud, Batallon San Patricio 112, San Pedro Garza Garcia 66278, Nuevo Leon, Mexico.
EM garcianr@tec.mx
RI Garcia, Noemi/T-4688-2019; García-Rivas, Gerardo/F-5994-2012;
   Garcia-Rivas, Gerardo/A-9691-2011
OI Nieblas, Bianca/0000-0002-8513-6163; Noemi, Garcia/0000-0002-1137-0117;
   Garcia-Rivas, Gerardo/0000-0003-4731-3293; RIVERA ALVAREZ, ROSA
   IRAIS/0000-0001-8425-4128; Perez-Trevino, Perla/0000-0002-0076-5738
FU School of Medicine of the Tecnologico de Monterrey; Consejo Nacional de
   Ciencia y Tecnologia-Mexico (CONACyT) [181460, 256577]; CONACyT
FX This work was partially supported by the School of Medicine of the
   Tecnologico de Monterrey as well as by the Consejo Nacional de Ciencia y
   Tecnologia-Mexico (CONACyT), grants 181460 (N.G.) and 256577 (G.G.R),
   and scholarship from CONACyT to Irais Rivera-Alvarez. We also thank
   Hipolito O. Miranda, MS, for skillful technical support.
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NR 87
TC 4
Z9 4
U1 0
U2 6
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0024-3205
EI 1879-0631
J9 LIFE SCI
JI Life Sci.
PD SEP 1
PY 2020
VL 256
AR 117965
DI 10.1016/j.lfs.2020.117965
PG 12
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA NB8KX
UT WOS:000560764500006
PM 32544463
DA 2025-06-11
ER

PT J
AU Matsumoto, AK
   Maes, M
   Michelin, AP
   Soares, AE
   Semeao, LD
   Godeny, P
   Venturini, D
   Barbosa, DS
   Delfino, VDA
AF Matsumoto, Andressa Keiko
   Maes, Michael
   Michelin, Ana Paula
   Soares, Abel Esteves
   Semeao, Laura de Oliveira
   Godeny, Paula
   Venturini, Danielle
   Barbosa, Decio Sabbatini
   Alvares Delfino, Vinicius Daher
TI Vitamin D deficiency is not associated with increased oxidative stress
   in chronic kidney disease pre-dialysis patients
SO JORNAL BRASILEIRO DE NEFROLOGIA
LA English
DT Article
DE Renal Insufficiency; Chronic; Oxidative Stress; Vitamin D
ID PRACTICE GUIDELINES; METABOLIC SYNDROME; NITRIC-OXIDE; INFLAMMATION;
   CLASSIFICATION; PREVALENCE; PHOSPHATE; CALCIUM; RISK
AB Introduction: The progressive decline in 25-hydroxyvitamin D [25(OH)D] in chronic kidney disease (CKD) limits the kidney ability of synthesizing the vitamin. Vitamin D deficiency as defined by KDIGO (25(OH)D <20 ng/mL) is prevalent in CKD patients and associated to oxidative stress (OS). We studied a possible association between vitamin D deficiency and OS in pre-dialysis patients. Methods: A cross-sectional study with 206 CKD patients was carried out. Laboratory tests for 25(OH)D, 1,25(OH)2D, inflammatory markers, and OS were added to routine tests including creatinine, albumin, calcium, phosphorus, alkaline phosphatase, iPTH, glucose, hemoglobin, uric acid, total cholesterol, LDL, HDL, and triglycerides. Results: Vitamin D deficiency was present in 55 CKD patients and normal vitamin D levels were seen in 149 patients. There was a significant association between vitamin D and estimated glomerular filtration rate (eGRF). Homocysteine levels were best predicted by eGRF, sex, and age; high sensitivity C-reactive protein (hsCRP) by staging and BMI; nitric oxide metabolites (NOx) were increased in late disease; leptin was influenced by BMI and higher in women than man; and adiponectin levels were higher in women. Conclusions: OS biomarkers were not correlated with vitamin D deficiency but increased NOx were seen in stages 4-5 CKD patients. Even though a relatively large number of CKD patients was included and a broad number of OS and inflammatory biomarkers were used in this studied we failed to find an association between vitamin D levels and eGRF. More studies are needed to evaluate the influence of vitamin D status in OS in pre-dialysis CKD patients.
C1 [Matsumoto, Andressa Keiko; Michelin, Ana Paula; Semeao, Laura de Oliveira; Godeny, Paula; Venturini, Danielle; Barbosa, Decio Sabbatini] Univ Estadual Londrina, Dept Patol Anal Clin & Toxicol, Londrina, Parana, Brazil.
   [Maes, Michael] Deakin Univ, IMPACT Res Ctr, Geelong, Vic, Australia.
   [Maes, Michael] Chulalongkorn Univ, Fac Med, Dept Psychiat, Bangkok, Thailand.
   [Maes, Michael] Univ Estadual Londrina, Ctr Ciencias Saude, Programa Posgrad Ciencias Saude, Londrina, PR, Brazil.
   [Soares, Abel Esteves; Alvares Delfino, Vinicius Daher] Univ Estadual Londrina, Dept Med Interna, Secao Nefrol, Londrina, PR, Brazil.
C3 Universidade Estadual de Londrina; Deakin University; Chulalongkorn
   University; Universidade Estadual de Londrina; Universidade Estadual de
   Londrina
RP Matsumoto, AK (corresponding author), Univ Estadual Londrina, Dept Patol Anal Clin & Toxicol, Londrina, Parana, Brazil.
EM dessamatsu@hotmail.com.br
RI Venturini, Danielle/HPH-1330-2023; Maes, Michael/B-8546-2011;
   /E-7312-2015
OI Semeao, Laura/0000-0001-8096-7307; Maes, Michael/0000-0002-2012-871X; ,
   ABEL ESTEVES SOARES/0000-0001-6028-2909; Godeny,
   Paula/0000-0002-8158-2000; /0000-0003-3986-9873
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NR 40
TC 2
Z9 2
U1 0
U2 1
PU SOC BRASILEIRA NEFROLOGIA
PI SAO PAULO
PA RUA MAVCHADO BITTENCOURT, 205-5 ANDAR-CONJ 53-VILA CLEMENTINO, SAO
   PAULO, 00000, BRAZIL
SN 0101-2800
EI 2175-8239
J9 J BRAS NEFROL
JI J. Bras. Nefrol.
PY 2020
VL 42
IS 4
BP 420
EP 428
DI 10.1590/2175-8239-JBN-2019-0156
PG 9
WC Urology & Nephrology
WE Emerging Sources Citation Index (ESCI)
SC Urology & Nephrology
GA VL4PL
UT WOS:000852604500008
PM 32406474
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Sharifi, N
   Amani, R
   Hajiani, E
   Cheraghian, B
AF Sharifi, Nasrin
   Amani, Reza
   Hajiani, Eskandar
   Cheraghian, Bahman
TI Does vitamin D improve liver enzymes, oxidative stress, and inflammatory
   biomarkers in adults with non-alcoholic fatty liver disease? A
   randomized clinical trial
SO ENDOCRINE
LA English
DT Article
DE Vitamin D; Non-alcoholic fatty liver disease; Inflammation; Oxidative
   stress
ID D SUPPLEMENTATION; INSULIN-RESISTANCE; METABOLIC SYNDROME; TRANSFORMING
   GROWTH-FACTOR-BETA-1; SYSTEMIC INFLAMMATION; 25-HYDROXYVITAMIN D-3;
   PARATHYROID-HORMONE; LIPID-PEROXIDATION; CHRONIC HEPATITIS; ASSOCIATION
AB The aim of this study was to investigate the effects of vitamin D supplementation on serum aminotransferases, insulin resistance, oxidative stress, and inflammatory biomarkers in adult patients with non-alcoholic fatty liver disease (NAFLD). Fifty-three patients with NAFLD were enrolled in a parallel, double-blind, placebo-controlled study. The patients were randomly allocated to receive either one oral pearl consisting of 50,000 IU vitamin D3 (n = 27) or a placebo (n = 26), every 14 days for 4 months. Serum aminotransferases, high-sensitive C-reactive protein (hs-CRP), tumor necrosis factor alpha, malondialdehyde (MDA), total antioxidant capacity, transforming growth factor beta(1), as well as grade of hepatic steatosis and homeostasis model assessment of insulin resistance were assessed pre- and post-intervention. In patients who received vitamin D supplement compared to the controls, the median of serum 25(OH)D-3 significantly increased (16.2 vs. 1.6 ng/ml, P < 0.001). This increase accompanied by significant decrease in serum MDA (-2.09 vs. -1.23 ng/ml, P = 0.03) and near significant changes in serum hs-CRP (-0.25 vs. 0.22 mg/l, P = 0.06). These between-group differences remained significant even after controlling for baseline covariates. Other variables showed no significant changes. Improved vitamin D status led to amelioration in serum hs-CRP and MDA in patients with NAFLD. This might be considered as an adjunctive therapy to attenuate systemic inflammation and lipid peroxidation alongside other treatments for NAFLD patients.
C1 [Sharifi, Nasrin] Ahvaz Jundishapur Univ Med Sci, Fac Paramed, Dept Nutr, Ahvaz, Iran.
   [Amani, Reza] Ahvaz Jundishapur Univ Med Sci, Diabet Res Ctr, Hlth Res Inst, Dept Nutr, Ahvaz, Iran.
   [Hajiani, Eskandar] Ahvaz Jundishapur Univ Med Sci, Res Inst Infect Dis Digest Syst, Ahvaz, Iran.
   [Cheraghian, Bahman] Ahvaz Jundishapur Univ Med Sci, Dept Epidemiol & Biostat, Ahvaz, Iran.
C3 Ahvaz Jundishapur University of Medical Sciences (AJUMS); Ahvaz
   Jundishapur University of Medical Sciences (AJUMS); Ahvaz Jundishapur
   University of Medical Sciences (AJUMS); Ahvaz Jundishapur University of
   Medical Sciences (AJUMS)
RP Amani, R (corresponding author), Ahvaz Jundishapur Univ Med Sci, Diabet Res Ctr, Hlth Res Inst, Dept Nutr, Ahvaz, Iran.
EM sharifi.nsr@gmail.com; rezaamani@hotmail.com; ehajiani@gmail.com;
   Cheraghian2000@yahoo.com
RI cheraghian, bahman/L-8808-2017; Sharifi, Nasrin/G-7661-2017; hajiani,
   eskandar/S-7352-2017; Amani, Reza/U-7483-2017
OI Sharifi, Nasrin/0000-0002-2879-5883; hajiani,
   eskandar/0000-0002-1014-1996; Amani, Reza/0000-0002-0074-4080;
   Cheraghian, Bahman/0000-0001-5446-6998
FU Jundishapur University of Medical Sciences [RDC-9105]
FX This work was financially supported by a Grant (No. RDC-9105) from
   Vice-Chancellor for Research Affairs of Jundishapur University of
   Medical Sciences and approved by the Research Institute for Infectious
   Diseases of the Digestive System, Jundishapur University of Medical
   Sciences, Ahvaz, Iran. Also, it was a part of PhD thesis of Nasrin
   Sharifi, student of Jundishapur University of Medical Sciences. The
   authors wish to thank Dr. Amir Hossein Sina from Danesh Lab in Ahvaz for
   his kind help in laboratory test assessment. We also thank Mr. Amir
   Mansour Vatankhah, and Dr. Mehran Messgari for their cooperation in
   measuring biochemical factors.
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NR 59
TC 198
Z9 207
U1 0
U2 31
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1355-008X
EI 1559-0100
J9 ENDOCRINE
JI Endocrine
PD SEP
PY 2014
VL 47
IS 1
BP 70
EP 80
DI 10.1007/s12020-014-0336-5
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA AS2CS
UT WOS:000344087600010
PM 24968737
DA 2025-06-11
ER

PT J
AU Mandavia, CH
   Aroor, AR
   De Marco, VG
   Sowers, JR
AF Mandavia, Chirag H.
   Aroor, Annayya R.
   De Marco, Vincent G.
   Sowers, James R.
TI Molecular and metabolic mechanisms of cardiac dysfunction in diabetes
SO LIFE SCIENCES
LA English
DT Review
DE Diabetes; RAAS; Cardiac dysfunction; Cardiorenal metabolic syndrome;
   Diabetic cardiomyopathy; Insulin resistance
ID ANGIOTENSIN-ALDOSTERONE-SYSTEM; ACTIVATED PROTEIN-KINASE; NF-KAPPA-B;
   OXIDATIVE STRESS; INSULIN-RESISTANCE; MINERALOCORTICOID RECEPTOR;
   CARDIOVASCULAR-DISEASE; MYOCARDIAL FIBROSIS; TNF-ALPHA; CARDIOMYOPATHY
AB Diabetes mellitus type 2 (T2DM) is a widespread chronic medical condition with prevalence bordering on the verge of an epidemic. It is of great concern that cardiovascular disease is more common in patients with diabetes than the non-diabetic population. While hypertensive and ischemic heart disease is more common in diabetic patients, there is another type of heart disease in diabetes that is not associated with hypertension or coronary artery disease. This muscle functional disorder is termed "diabetic cardiomyopathy". Diastolic dysfunction characterized by impaired diastolic relaxation time and reduced contractility precedes systolic dysfunction and is the main pathogenic hallmark of this condition. Even though the pathogenesis of "diabetic cardiomyopathy" is still controversial, impaired cardiac insulin sensitivity and metabolic overload are emerging as major molecular and metabolic mechanisms for cardiac dysfunction. Systemic insulin resistance, hyperinsulinemia, dysregulation of adipokine secretion, increases in circulating levels of inflammatory mediators, aberrant activation of renin angiotensin aldosterone system (RAAS), and increased oxidative stress contribute dysregulated insulin and metabolic signaling in the heart and development of diastolic dysfunction. In addition, maladaptive calcium homeostasis and endothelial cell dysregulation endoplasmic reticular stress play a potential role in cardiomyocyte fibrosis/diastolic dysfunction. In this review, we will focus on emerging molecular and metabolic pathways underlying cardiac dysfunction in diabetes. Elucidation of these mechanisms should provide a better understanding of the various cardiac abnormalities associated with diastolic dysfunction and its progression to systolic dysfunction and heart failure. (c) 2012 Elsevier Inc. All rights reserved.
C1 [Mandavia, Chirag H.; Aroor, Annayya R.; De Marco, Vincent G.; Sowers, James R.] Univ Missouri, Sch Med, Dept Internal Med, Columbia, MO 65212 USA.
   [De Marco, Vincent G.; Sowers, James R.] Univ Missouri, Sch Med, Dept Med Pharmacol & Physiol, Columbia, MO 65212 USA.
   [Mandavia, Chirag H.; Aroor, Annayya R.; De Marco, Vincent G.; Sowers, James R.] Univ Missouri, Sch Med, Diabet & Cardiovasc Ctr, Columbia, MO 65212 USA.
   [Sowers, James R.] Univ Missouri, Sch Med, Harry S Truman Vet Affair Med Ctr, Columbia, MO 65212 USA.
C3 University of Missouri System; University of Missouri Columbia;
   University of Missouri System; University of Missouri Columbia;
   University of Missouri System; University of Missouri Columbia; US
   Department of Veterans Affairs; Veterans Health Administration (VHA);
   Harry S. Truman Memorial Veterans' Hospital; University of Missouri
   System; University of Missouri Columbia
RP Sowers, JR (corresponding author), Univ Missouri, Diabet & Cardiovasc Ctr, 1 Hosp Dr, Columbia, MO 65212 USA.
EM sowersj@health.missouri.edu
OI DeMarco, Vincent/0000-0003-2092-9995
FU NIH [R01 HL73101-01A, R01 HL107910-01]; Veterans Affairs Merit System
   [0018]
FX The authors would like to thank Brenda Hunter for her editorial
   assistance. Funding: This research was supported by the NIH (R01
   HL73101-01A and R01 HL107910-01) and the Veterans Affairs Merit System
   (0018) for JRS.
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NR 110
TC 147
Z9 157
U1 0
U2 65
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0024-3205
EI 1879-0631
J9 LIFE SCI
JI Life Sci.
PD MAR 28
PY 2013
VL 92
IS 11
SI SI
BP 601
EP 608
DI 10.1016/j.lfs.2012.10.028
PG 8
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA 108OK
UT WOS:000316305100002
PM 23147391
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Nagasu, H
   Satoh, M
   Yorimitsu, D
   Tomita, N
   Sasaki, T
   Kashihara, N
AF Nagasu, Hajime
   Satoh, Minoru
   Yorimitsu, Daisuke
   Tomita, Naruya
   Sasaki, Tamaki
   Kashihara, Naoki
TI Comparison of Combination Therapy of Olmesartan plus Azelnidipine or
   Hydrochlorothiazide on Renal and Vascular Damage in SHR/NDmcr-cp Rats
SO KIDNEY & BLOOD PRESSURE RESEARCH
LA English
DT Article
DE Azelnidipine; Calcium channel blockers; Chronic kidney disease;
   Combination therapy; Angiotensin receptor blockers; Hydrochlorothiazide;
   NAD(P)H oxidase activity; Olmesartan; Renal and vascular damage;
   SHR/NDmcr-cp rats
ID CALCIUM-CHANNEL BLOCKER; AT(1) RECEPTOR BLOCKER; CHRONIC KIDNEY-DISEASE;
   NITRIC-OXIDE SYNTHASE; ANGIOTENSIN-II; ENDOTHELIAL DYSFUNCTION; NAD(P)H
   OXIDASE; NADPH OXIDASE; GLOMERULAR INJURY; OBESE RATS
AB Background: Although the recommended target blood pressure for patients with chronic kidney disease is < 130/80 mm Hg, this is difficult to achieve by treatment with an angiotensin receptor blocker alone. Addition of either a calcium channel blocker or a diuretic is suggested as second-line medication; however, which combination is most beneficial for target-organ protection remains unknown. Methods: SHR/NDmcr-cp rats were administered no medications ( control) or low-dose olmesartan for 2 weeks and then either olmesartan at an increased dose, azelnidipine, or the hydrochlorothiazide for 3 weeks. We assessed oxidative stress in the kidney and aorta, and endothelial function. Results: Urinary protein excretion was lower in all treated rats than in control rats. Oxidative stress caused by activation of NAD(P)H oxidase was observed in the glomeruli and aorta of control rats and was significantly suppressed in the olmesartan/azelnidipine (Olm/Azl) groups. Combination therapy with olmesartan and hydrochlorothiazide (Olm/HCTZ) however failed to suppress oxidative stress. The Olm/Azl groups maintained the endothelial surface layer in the glomeruli and protected endothelial function in the aorta. Conclusion: In an animal model of metabolic syndrome, a combination of Olm/Azl is superior to a combination of Olm/HCTZ in terms of prevention of glomerular and vascular injuries. Copyright (C) 2011 S. Karger AG, Basel
C1 [Nagasu, Hajime; Satoh, Minoru; Yorimitsu, Daisuke; Tomita, Naruya; Sasaki, Tamaki; Kashihara, Naoki] Kawasaki Med Sch, Dept Hypertens & Nephrol, Kurashiki, Okayama 7010192, Japan.
C3 Kawasaki Medical School
RP Nagasu, H (corresponding author), Kawasaki Med Sch, Dept Hypertens & Nephrol, 577 Matsushima, Kurashiki, Okayama 7010192, Japan.
EM zajiten1@gmail.com
RI Satoh, Minoru/E-2421-2011
FU KAKENHI [21591047]; Grants-in-Aid for Scientific Research [21591047]
   Funding Source: KAKEN
FX This work was supported by the KAKENHI, a Grant-in-Aid for Scientific
   Research (C) ( No. 21591047) to Naoki Kashihara. We thank Ms. Etsuko
   Yorimasa and Ms. Asuka Maeda for animal care, and Ms. Satomi Hanada and
   Ms. Keiko Ehara for help with the in vitro assays.
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NR 40
TC 10
Z9 10
U1 0
U2 2
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1420-4096
EI 1423-0143
J9 KIDNEY BLOOD PRESS R
JI Kidney Blood Pressure Res.
PY 2011
VL 34
IS 2
BP 87
EP 96
DI 10.1159/000323535
PG 10
WC Physiology; Urology & Nephrology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology; Urology & Nephrology; Cardiovascular System & Cardiology
GA 734VU
UT WOS:000288369200004
PM 21273789
OA Bronze
DA 2025-06-11
ER

PT J
AU Hirao, K
   Maruyama, T
   Ohno, Y
   Hirose, H
   Shimada, A
   Takei, I
   Murata, M
   Morii, T
   Eguchi, T
   Hayashi, M
   Saruta, T
   Itoh, H
AF Hirao, K.
   Maruyama, T.
   Ohno, Y.
   Hirose, H.
   Shimada, A.
   Takei, I.
   Murata, M.
   Morii, T.
   Eguchi, T.
   Hayashi, M.
   Saruta, T.
   Itoh, H.
TI Association of increased reactive oxygen species production with
   abdominal obesity in type 2 diabetes
SO OBESITY RESEARCH & CLINICAL PRACTICE
LA English
DT Article
DE Reactive oxygen species; Abdominal obesity; Type 2 diabetes; Metabolic
   syndrome; Oxidative stress
ID CYPRIDINA LUCIFERIN ANALOG; BODY-MASS INDEX; METABOLICALLY-OBESE;
   NORMAL-WEIGHT; INSULIN-RESISTANCE; ADIPOSE-TISSUE; NADPH OXIDASE;
   OXIDATIVE STRESS; VISCERAL FAT; FOLLOW-UP
AB Objective: The close relationship between oxidative stress and abdominal obesity is well known, but the association is unclear in diabetic patients. The aim of this study was to confirm that increased reactive oxygen species (ROS) production is associated with abdominal obesity in diabetic patients.
   Methods: ROS production was assayed in Epstein-Barr virus-transformed immortalized lymphoblasts by means of a cypridina luciferin analogue chemiluminescence method. We divided 96 Japanese male diabetic patients into 2 groups: patients with abdominal obesity according to the accepted Japanese criteria (waist circumference is more than 85 cm) (group AO, n = 36); and patients without abdominal obesity (group N, n = 60). Subjects with body mass index (BMI) in the normal range (21 <= BMI < 25 kg/m(2)) were then selected and assigned to 2 subgroups (group AO(normal-BMI) [n = 13]; and group Nnormal-BMI [n = 35]); ROS production was compared between these 2 subgroups.
   Results: Stimulation with arachidonic acid (AA) and 12-O-tetradecanoylphorbol-13-acetate (TPA) increased ROS production in lymphoblasts, which was more greatly elevated in lymphoblasts derived from group AO than those from group N. Even in the subjects with normal BMI, AA-and TPA-stimulated ROS production in group AO was significantly higher than that in group N.
   Conclusions: These data suggest that increased ROS production is more closely associated with abdominal obesity than high BMI or insulin resistance in diabetic patients. (C) 2009 Asian Oceanian Association for the Study of Obesity. Published by Elsevier Ltd. All rights reserved.
C1 [Hirao, K.; Maruyama, T.; Ohno, Y.; Hirose, H.; Shimada, A.; Murata, M.; Morii, T.; Eguchi, T.; Hayashi, M.; Saruta, T.; Itoh, H.] Keio Univ, Sch Med, Dept Internal Med, Shinjuku Ku, Tokyo 1608582, Japan.
   [Takei, I.] Ichikawa Gen Hosp, Tokyo Dent Coll, Dept Internal Med, Ichikawa, Chiba, Japan.
C3 Keio University; Tokyo Dental College
RP Hirao, K (corresponding author), Keio Univ, Sch Med, Dept Internal Med, Shinjuku Ku, 35 Shinanomachi, Tokyo 1608582, Japan.
EM endeavor@aa.isas.ne.jp
RI Eguchi, Takashi/AAS-9215-2021; Hayashi, Matsuhiko/J-4748-2013
FU Takeda Pharmaceutical Company Limited
FX This work was supported by Takeda Pharmaceutical Company Limited.
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NR 49
TC 9
Z9 9
U1 0
U2 6
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1871-403X
EI 1878-0318
J9 OBES RES CLIN PRACT
JI Obes. Res. Clin. Pract.
PD APR-JUN
PY 2010
VL 4
IS 2
BP E83
EP E90
DI 10.1016/j.orcp.2009.09.004
PG 8
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA V24JT
UT WOS:000208407400001
PM 24345646
DA 2025-06-11
ER

PT J
AU Flauzino, T
   Simao, ANC
   Pereira, WLDJ
   Alfieri, DF
   Oliveira, SR
   Kallaur, AP
   Lozovoy, MAB
   Kaimen-Maciel, DR
   Maes, M
   Reiche, EMV
AF Flauzino, Tamires
   Colado Simao, Andrea Name
   de Carvalho Jennings Pereira, Wildea Lice
   Alfieri, Daniela Frizon
   Oliveira, Sayonara Rangel
   Kallaur, Ana Paula
   Batisti Lozovoy, Marcell Alysson
   Kaimen-Maciel, Damacio Ramon
   Maes, Michael
   Vissoci Reiche, Edna Maria
TI Disability in multiple sclerosis is associated with age and
   inflammatory, metabolic and oxidative/nitrosative stress biomarkers:
   results of multivariate and machine learning procedures
SO METABOLIC BRAIN DISEASE
LA English
DT Article
DE Multiple sclerosis; Disability; Inflammation; Oxidative stress;
   Homocysteine; Biomarkers
ID PLASMA HOMOCYSTEINE LEVELS; OXIDATIVE STRESS; T-CELL; PROTEIN
   CARBONYLATION; DISEASE PROGRESSION; INSULIN-RESISTANCE; STATUS SCALE;
   RISK-FACTOR; TH17 CELLS; BRAIN
AB The aim of this study was to evaluate the immune-inflammatory, metabolic, and nitro-oxidative stress (IM&NO) biomarkers as predictors of disability in multiple sclerosis (MS) patients. A total of 122 patients with MS were included; their disability was evaluated using the Expanded Disability Status Scale (EDSS) and IM&NO biomarkers were evaluated in peripheral blood samples. Patients with EDSS >= 3 were older and showed higher homocysteine, uric acid, advanced oxidized protein products (AOPP) and low-density lipoprotein (LDL)-cholesterol and higher rate of metabolic syndrome (MetS), while high-density lipoprotein (HDL)-cholesterol was lower than in patients with EDSS <3; 84.6% of all patients were correctly classified in these EDSS subgroups. We found that 36.3% of the variance in EDSS score was explained by age, Th17/T regulatory (Treg) and LDL/HDL ratios and homocysteine (all positively related) and body mass index (BMI) (inversely related). After adjusting for MS treatment modalities, the effects of the LDL/HDL and zTh17/Treg ratios, homocysteine and age on disability remained, whilst BMI was no longer significant. Moreover, carbonyl proteins were associated with increased disability. In conclusion, the results showed that an inflammatory Th17 profile coupled with age and increased carbonyl proteins were the most important variables associated with high disability followed at a distance by homocysteine, MetS and LDL/HDL ratio. These data underscore that IM&NO pathways play a key role in increased disability in MS patient and may be possible new targets for the treatment of these patients. Moreover, a panel of these laboratory biomarkers may be used to predict the disability in MS.
C1 [Flauzino, Tamires; de Carvalho Jennings Pereira, Wildea Lice; Alfieri, Daniela Frizon; Kallaur, Ana Paula] Univ Estadual Londrina, Postgrad Program, Hlth Sci Ctr, Londrina, Parana, Brazil.
   [Colado Simao, Andrea Name; Oliveira, Sayonara Rangel; Batisti Lozovoy, Marcell Alysson; Vissoci Reiche, Edna Maria] Univ Estadual Londrina, Univ Hosp, Hlth Sci Ctr, Dept Pathol Clin Anal & Toxicol, Av Robert Koch 60, BR-86038350 Londrina, Parana, Brazil.
   [Kaimen-Maciel, Damacio Ramon] Univ Londrina, Dept Clin Med, Londrina, Parana, Brazil.
   [Maes, Michael] Deakin Univ, Sch Med, Impact Strateg Res Ctr, Geelong, Vic, Australia.
   [Maes, Michael] King Chulalongkorn Mem Hosp, Dept Psychiat, Bangkok, Thailand.
C3 Universidade Estadual de Londrina; Universidade Estadual de Londrina;
   Deakin University; Chulalongkorn University
RP Reiche, EMV (corresponding author), Univ Estadual Londrina, Univ Hosp, Hlth Sci Ctr, Dept Pathol Clin Anal & Toxicol, Av Robert Koch 60, BR-86038350 Londrina, Parana, Brazil.
EM reiche@sercomtel.com.br
RI Lozovoy, Marcell/AAM-4897-2021; kallaur, Ana/AAO-8945-2020; Maes,
   Michael/B-8546-2011; Simão, Andrea/AAM-4892-2021; Alfieri,
   Daniela/LSI-6403-2024; Reiche, EDNa/AAD-4186-2020; Reiche, Edna Maria
   Vissoci/C-4102-2013
OI Kallaur, Ana Paula/0000-0001-9563-971X; Maes,
   Michael/0000-0002-2012-871X; Reiche, Edna Maria
   Vissoci/0000-0001-6507-2839; Alfieri, Daniela/0000-0002-0217-9329
FU Novartis Biosciences S.A [CFTY720DBR07T]; Coordination for the
   Improvement of Higher Level of Education Personnel (CAPES) of Brazilian
   Ministry of Education; Institutional Program for Scientific Initiation
   Scholarship (PIBIC) of the National Council for Scientific and
   Technological Development (CNPq)
FX This study was partially and financially supported by Novartis
   Biosciences S.A for the development of the research according to the
   Researcher's Initiative Study CFTY720DBR07T. The authors do not receive
   any reimbursement or financial benefits and declare that they have no
   competing interests. Novartis Biosciences S.A. played no role in the
   design, methods, data management or analysis or in the decision to
   publish. The study was also supported by grants from Coordination for
   the Improvement of Higher Level of Education Personnel (CAPES) of
   Brazilian Ministry of Education; Institutional Program for Scientific
   Initiation Scholarship (PIBIC) of the National Council for Scientific
   and Technological Development (CNPq).
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NR 80
TC 21
Z9 22
U1 0
U2 6
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0885-7490
EI 1573-7365
J9 METAB BRAIN DIS
JI Metab. Brain Dis.
PD OCT
PY 2019
VL 34
IS 5
BP 1401
EP 1413
DI 10.1007/s11011-019-00456-7
PG 13
WC Endocrinology & Metabolism; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology
GA IX8HA
UT WOS:000485925900015
PM 31302813
DA 2025-06-11
ER

PT J
AU Blüher, M
   Bashan, N
   Shai, I
   Harman-Boehm, I
   Tarnovscki, T
   Avinaoch, E
   Stumvoll, M
   Dietrich, A
   Klöting, N
   Rudich, A
AF Blueher, Matthias
   Bashan, Nava
   Shai, Iris
   Harman-Boehm, Ilana
   Tarnovscki, Tanya
   Avinaoch, Eliezer
   Stumvoll, Michael
   Dietrich, Arne
   Kloeting, Nora
   Rudich, Assaf
TI Activated Ask1-MKK4-p38MAPK/JNK Stress Signaling Pathway in Human
   Omental Fat Tissue May Link Macrophage Infiltration to Whole-Body
   Insulin Sensitivity
SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Article
ID ADIPOSE-TISSUE; ENDOPLASMIC-RETICULUM; REGULATING KINASE-1; OXIDATIVE
   STRESS; METABOLIC SYNDROME; SUBCUTANEOUS FAT; FAMILY PROTEINS; OBESITY;
   DISEASE; IMPACT
AB Context: Adipose tissue in obesity is thought to be exposed to various stresses, predominantly in intraabdominal depots. We recently reported that p38MAPK and Jun N-terminal kinase (JNK), but not ERK and inhibitory-kappa B kinase beta, are more highly expressed and activated in human omental (OM) adipose tissue in obesity.
   Objective: The aim was to investigate upstream components of the pathways that culminate in activation of p38MAPK and JNK.
   Setting and Patients: Phosphorylation and expression of kinases were studied in paired samples of OM and sc adipose tissue from lean and obese subjects of two different cohorts (n = 36 and n = 196) by Western and real-time PCR analyses. The association with fat distribution, macrophage infiltration, insulin sensitivity, and glucose metabolism was assessed by correlation analyses.
   Results: The amount of phosphorylated forms of the kinases provided evidence for an activated stress-sensing pathway consisting of the MAP3K Ask1 (but not MLK3 or Tak1), and the MAP2Ks MKK4, 3/6, (but not MKK7), specifically in OM. OM Ask1-mRNA was more highly expressed in predominantly intraabdominally obese persons and most strongly correlated with estimated visceral fat. Diabetes was associated with higher OM Ask1-mRNA only in the lean group. In OM, macrophage infiltration strongly correlated with Ask1-mRNA, but the obesity-associated increase in Ask1-mRNA could largely be attributed to the adipocyte cell fraction. Finally, multivariate regression analyses revealed OM-Ask1 as an independent predictor of whole-body glucose uptake in euglycemic-hyperinsulinemic clamps.
   Conclusions: An Ask1-MKK4-p38MAPK/JNK pathway reflects adipocyte stress associated with adipose tissue inflammation, linking visceral adiposity to whole-body insulin resistance in obesity. (J Clin Endocrinol Metab 94: 2507-2515, 2009)
C1 [Rudich, Assaf] Ben Gurion Univ Negev, Fac Hlth Sci, Dept Clin Biochem, IL-84103 Beer Sheva, Israel.
   [Blueher, Matthias; Stumvoll, Michael; Kloeting, Nora] Univ Leipzig, Dept Med, D-04107 Leipzig, Germany.
   [Dietrich, Arne] Univ Leipzig, Dept Surg 2, D-04107 Leipzig, Germany.
   [Shai, Iris; Rudich, Assaf] Ben Gurion Univ Negev, S Daniel Abraham Ctr Hlth & Nutr, IL-84103 Beer Sheva, Israel.
   [Harman-Boehm, Ilana; Avinaoch, Eliezer] Soroka Med Ctr, IL-84101 Beer Sheva, Israel.
C3 Ben-Gurion University of the Negev; Leipzig University; Leipzig
   University; Ben-Gurion University of the Negev; Ben-Gurion University of
   the Negev; Soroka Medical Center
RP Rudich, A (corresponding author), Ben Gurion Univ Negev, Fac Hlth Sci, Dept Clin Biochem, IL-84103 Beer Sheva, Israel.
EM rudich@bgu.ac.il
RI RUDICH, ASSAF/MSY-8816-2025; Stumvoll, Michael/ABE-1121-2021; SHAI,
   IRIS/HJO-8533-2023
OI Shai, Iris/0000-0001-9050-4605; Rudich, Assaf/0000-0002-1366-1444;
   Stumvoll, Michael/0000-0001-6225-8240
FU Israel Association for the Study of Diabetes; Israel Science Foundation
   [118/06]; Deutsche Forschungsgemeinschaft, [KFO 152]; Fraida Foundation
   in Diabetes Research
FX Address all correspondence and requests for reprints to: Assaf Rudich,
   M. D.,Ph.D., Department of Clinical Biochemistry and the International
   Center for Health and Nutrition, Faculty of Health Sciences, Ben-Gurion
   University of the Negev, Beer-Sheva 84103, Israel. E-mail:
   rudich@bgu.ac.il. This work was supported in part by grants from the
   Israel Association for the Study of Diabetes (to N.B., A.R., and M.S.),
   The Israel Science Foundation Grant 118/06 (to N.B. and A. R.), and the
   Deutsche Forschungsgemeinschaft, Clinic Research Group Atherobesity KFO
   152 (to M. B. and M. S.). N.B. is Chair of the Fraida Foundation in
   Diabetes Research. Disclosure Summary: All authors (M.B., N.B., I.S.,
   I.H.-B., T.T., E.A., M.S., A.D., N.K., and A.R.) have nothing to
   disclose.
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NR 40
TC 88
Z9 93
U1 0
U2 5
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0021-972X
EI 1945-7197
J9 J CLIN ENDOCR METAB
JI J. Clin. Endocrinol. Metab.
PD JUL
PY 2009
VL 94
IS 7
BP 2507
EP 2515
DI 10.1210/jc.2009-0002
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 467UB
UT WOS:000267767500047
PM 19351724
OA Bronze
DA 2025-06-11
ER

PT J
AU Mouhid, L
   de Cedrón, MG
   Quijada-Freire, A
   Fernández-Marcos, PJ
   Reglero, G
   Fornari, T
   de Molina, AR
AF Mouhid, Lamia
   Gomez de Cedron, Marta
   Quijada-Freire, Adriana
   Fernandez-Marcos, Pablo J.
   Reglero, Guillermo
   Fornari, Tiziana
   Ramirez de Molina, Ana
TI Yarrow Supercritical Extract Ameliorates the Metabolic Stress in a Model
   of Obesity Induced by High-Fat Diet
SO NUTRIENTS
LA English
DT Article
DE yarrow supercritical extract; obesity; diabetes; insulin resistance;
   hypercholesterolemia; fatty liver; cancer
ID INSULIN-RESISTANCE; ADIPOSE-TISSUE; DIABETES-MELLITUS; GENE-EXPRESSION;
   LIVER-DISEASE; PHYTOCHEMICALS; MECHANISMS; GLUCOSE
AB Nowadays, obesity and its associated metabolic disorders, including diabetes, metabolic syndrome, cardiovascular disease, or cancer, continue to be a health epidemic in westernized societies, and there is an increased necessity to explore anti-obesity therapies including pharmaceutical and nutraceutical compounds. Considerable attention has been placed on the identification of bioactive compounds from natural sources to manage the metabolic stress associated with obesity. In a previous work, we have demonstrated that a CO2 supercritical fluid extract from yarrow (Yarrow SFE), downregulates the expression of the lipogenic master regulator SREBF1 and its downstream molecular targets FASN and SCD in a tumoral context. Since obesity and diabetes are strongly considered high-risk factors for cancer development, herein, we aimed to investigate the potential therapeutic role of Yarrow SFE in the metabolic stress induced after a high-fat diet in mice. For this purpose, 32 C57BL/6 mice were distributed in four groups according to their diets: standard diet (SD); SD supplemented with Yarrow SFE (SD + Yarrow); high-fat diet (HFD); and HFD supplemented with Yarrow SFE (HFD + Yarrow). Fasting glycemia, insulin levels, homeostasis model assessment for insulin resistance (HOMA-IR), lipid profile, gene expression, and lipid content of liver and adipose tissues were analyzed after three months of treatment. Results indicate improved fasting glucose levels in plasma, enhanced insulin sensitivity, and diminished hypercholesterolemia in the HFD + Yarrow group compared to the HFD group. Mechanistically, Yarrow SFE protects liver from steatosis after the HFD challenge by augmenting the adipose tissue buffering capacity of the circulating plasma glucose.
C1 [Mouhid, Lamia; Gomez de Cedron, Marta; Quijada-Freire, Adriana; Reglero, Guillermo; Ramirez de Molina, Ana] CEI UAM CSIC, Mol Oncol & Nutr Genom Canc, IMDEA Food Inst, Madrid 28049, Spain.
   [Fernandez-Marcos, Pablo J.] CEI UAM CSIC, Metab Syndrome Grp, IMDEA Food Inst, Madrid 28049, Spain.
   [Reglero, Guillermo; Fornari, Tiziana] CEI UAM CSIC, Prod & Characterizat Novel Foods Dept, Inst Food Sci Res CIAL, Madrid 28049, Spain.
C3 Consejo Superior de Investigaciones Cientificas (CSIC); IMDEA Food
   Institute; IMDEA Food Institute; Consejo Superior de Investigaciones
   Cientificas (CSIC); Consejo Superior de Investigaciones Cientificas
   (CSIC); CSIC-UAM - Instituto de Investigacion en Ciencias de la
   Alimentacion (CIAL)
RP de Cedrón, MG; de Molina, AR (corresponding author), CEI UAM CSIC, Mol Oncol & Nutr Genom Canc, IMDEA Food Inst, Madrid 28049, Spain.
EM Lamia.Mouhid@imdea.org; marta.gomezdecedron@imdea.org;
   Adriana.quijada@imdea.org; pablojose.fernandez@imdea.org;
   guillermo.reglero@imdea.org; tiziana.fornari@uam.es;
   ana.ramirez@imdea.org
RI de Molina, Ana/AAA-3848-2019; Reglero, Guillermo/K-6658-2014;
   Fernandez-Marcos, Pablo J./F-1840-2016; Gomez de Cedron,
   Marta/M-7764-2014
OI Fernandez-Marcos, Pablo J./0000-0003-3515-4125; Reglero rada,
   Guillermo/0000-0002-7730-3486; Gomez de Cedron,
   Marta/0000-0002-0894-970X; Quijada, Adriana/0000-0001-6709-5620
FU Spanish Ministry of Science (Plan Nacional I + D + i)
   [AGL2016-76736-C3]; Regional Government of Community of Madrid
   [P2013/ABI-2728, P2018/BAA-4343-ALIBIRD2020-CM]; Ramon Areces
   Foundation; EU Structural Funds
FX This work was supported by the Spanish Ministry of Science (Plan
   Nacional I + D + i AGL2016-76736-C3), Regional Government of Community
   of Madrid (P2013/ABI-2728, ALIBIRD-CM; P2018/BAA-4343-ALIBIRD2020-CM),
   the Ramon Areces Foundation, and the EU Structural Funds.
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NR 37
TC 12
Z9 12
U1 1
U2 11
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JAN
PY 2020
VL 12
IS 1
AR 72
DI 10.3390/nu12010072
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA KQ3KN
UT WOS:000516825500072
PM 31888081
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU dos Santos, JM
   de Oliveira, DS
   Moreli, ML
   Benite-Ribeiro, SA
AF dos Santos, Julia Matzenbacher
   de Oliveira, Denise Silva
   Moreli, Marcos Lazaro
   Benite-Ribeiro, Sandra Aparecida
TI The role of mitochondrial DNA damage at skeletal muscle oxidative stress
   on the development of type 2 diabetes
SO MOLECULAR AND CELLULAR BIOCHEMISTRY
LA English
DT Article
DE Oxidative stress; MtDNA damage; Skeletal muscle; 8-Hydroxyguanosine
ID GLUCOSE-UPTAKE; METABOLIC SYNDROME; CONTRACTION; RETINOPATHY;
   MECHANISMS; EXERCISE; OBESITY; RATS
AB Reduced cellular response to insulin in skeletal muscle is one of the major components of the development of type 2 diabetes (T2D). Mitochondrial dysfunction involves in the accumulation of toxic reactive oxygen species (ROS) that leads to insulin resistance. The aim of this study was to verify the involvement of mitochondrial DNA damage at ROS generation in skeletal muscle during development of T2D. Wistar rats were fed a diet containing 60% fat over 8 weeks and at day 14 a single injection of STZ (25 mg/kg) was administered (T2D-induced). Control rats received standard food and an injection of citrate buffer. Blood and soleus muscle were collected. Abdominal fat was quantified as well as glucose, triglyceride, LDL, HDL, and total cholesterol in plasma and mtDNA copy number, cytochrome b (cytb) mRNA, 8-hydroxyguanosine, and 8-isoprostane (a marker of ROS) in soleus muscle. T2D-induced animal presented similar characteristics to humans that develop T2D such as changes in blood glucose, abdominal fat, LDL, HDL and cholesterol total. In soleus muscle 8-isoprostane, mtDNA copy number and 8-hydroxyguanosine were increased, while cytb mRNA was decreased in T2D. Our results suggest that in the development of T2D, when risks factors of T2D are present, intracellular oxidative stress increases in skeletal muscle and is associated with a decrease in cytb transcription. To overcome this process mtDNA increased but due to the proximity of ROS generation, mtDNA remains damaged by oxidation leading to an increase in ROS in a vicious cycle accounting to the development of insulin resistance and further T2D.
C1 [de Oliveira, Denise Silva; Benite-Ribeiro, Sandra Aparecida] Fed Univ Jatai, Inst Biociencias, Jatai, Go, Brazil.
   [Benite-Ribeiro, Sandra Aparecida] Fed Univ Jatai, Posgrad Biociencia Anim, Jatai, Go, Brazil.
   [dos Santos, Julia Matzenbacher; Moreli, Marcos Lazaro; Benite-Ribeiro, Sandra Aparecida] Fed Univ Jatai, Posgrad Ciencia Saude, Jatai, Go, Brazil.
   [dos Santos, Julia Matzenbacher] Detroit R&D Inc, 2727 2nd St,4113, Detroit, MI 48201 USA.
   [dos Santos, Julia Matzenbacher] Henry Ford Coll, Sci & Math Dept, Dearborn, MI 48128 USA.
C3 Detroit R&D
RP Benite-Ribeiro, SA (corresponding author), Fed Univ Jatai, Inst Biociencias, Jatai, Go, Brazil.; Benite-Ribeiro, SA (corresponding author), Fed Univ Jatai, Posgrad Biociencia Anim, Jatai, Go, Brazil.; dos Santos, JM; Benite-Ribeiro, SA (corresponding author), Fed Univ Jatai, Posgrad Ciencia Saude, Jatai, Go, Brazil.; dos Santos, JM (corresponding author), Detroit R&D Inc, 2727 2nd St,4113, Detroit, MI 48201 USA.; dos Santos, JM (corresponding author), Henry Ford Coll, Sci & Math Dept, Dearborn, MI 48128 USA.
EM jmsantos@detroitrandd.com; sandrabenite@ufg.br
RI Ribeiro, Sandra/HKW-4484-2023; Moreli, Marcos/AAC-9425-2019;
   Benite-Ribeiro, Sandra Aparecida/C-9865-2014; Santos, Julia
   M/D-5798-2016
OI Benite-Ribeiro, Sandra Aparecida/0000-0002-3741-3787; Santos, Julia
   M/0000-0003-2758-9452; Moreli, Marcos/0000-0002-9599-361X
FU National Council for Scientific and Technological Development
   [CNPq-301744/2014-9]
FX The authors would like to thanks the National Council for Scientific and
   Technological Development for the grant support (CNPq-301744/2014-9).
   Also, we would like Prof. Edesio Fialho dos Rei to provide the PCR
   equipment and Jefferson Fernando Naves Pinto for the technical support.
CR Ailanen L, 2017, J ENDOCRINOL, V234, P57, DOI 10.1530/JOE-16-0223
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NR 23
TC 25
Z9 27
U1 0
U2 7
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0300-8177
EI 1573-4919
J9 MOL CELL BIOCHEM
JI Mol. Cell. Biochem.
PD DEC
PY 2018
VL 449
IS 1-2
BP 251
EP 255
DI 10.1007/s11010-018-3361-5
PG 5
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA HI5ER
UT WOS:000456475800024
PM 29679277
DA 2025-06-11
ER

PT J
AU Storch, AS
   Rocha, HNM
   Garcia, VP
   Batista, GMD
   Mattos, JD
   Campos, MO
   Fuly, AL
   da Nóbrega, ACL
   Fernandes, IA
   Rocha, NG
AF Storch, Amanda Sampaio
   Miguens Rocha, Helena Naly
   Garcia, Vinicius Pacheco
   da Silva Batista, Gabriel Matheus
   Mattos, Joao Dario
   Campos, Monique Opuszcka
   Fuly, Andre Lopes
   Lucas da Nobrega, Antonio Claudio
   Fernandes, Igor Alexandre
   Rocha, Natalia Galito
TI Oscillatory shear stress induces hemostatic imbalance in healthy men
SO THROMBOSIS RESEARCH
LA English
DT Article
DE Atherosclerosis; Oscillatory shear stress; Hemostasis; Vascular
   remodeling
ID PLATELET-DERIVED MICROPARTICLES; PLASMINOGEN-ACTIVATOR INHIBITOR-1;
   HUMAN-ENDOTHELIAL-CELLS; FLOW-MEDIATED DILATION; TISSUE FACTOR ACTIVITY;
   IN-VITRO; METABOLIC SYNDROME; GENE-EXPRESSION; NITRIC-OXIDE;
   ATHEROSCLEROSIS
AB Introduction: In vitro and animal model studies have demonstrated that oscillatory shear can trigger vascular hemostasis and remodeling. However, the roles of hemodynamic forces in vascular human biology are not well understood. This study aimed to determine the effects of increasing oscillatory shear stress (OSS) on coagulation/fibrinolysis factors and matrix metalloproteinase-9 activity in healthy subjects.
   Materials and methods: Ten healthy males (35 +/- 7 years) underwent a 30-minute dominant forearm cuff occlusion (75mmHg) to exacerbate OSS in the brachial artery. Blood flow was quantified (Doppler ultrasound), and plasma samples were obtained from both arms at rest and during the last 30 s of cuff occlusion on the dominant arm. A proximal cuff (40mmHg, close to axilla) was also occluded to facilitate venous blood biomarker trapping.
   Results: The retrograde shear rate and oscillatory shear index were increased and the mean shear rate, mean blood velocity, and mean blood flow were decreased in the cuffed arm (p < 0.05 vs. baseline and non-cuffed arm). Cuff occlusion induced increases in platelet microparticle release (p=0.05 vs. baseline), prothrombin time (p < 0.05 vs. baseline and non-cuffed arm), tissue plasminogen activator (p < 0.01 vs. baseline and noncuffed arm), plasminogen activator inhibitor-1 (p < 0.02 vs. baseline and non-cuffed arm), and matrix metalloproteinase-9 activity (p=0.01 vs. baseline). No significant changes were found in the non-cuffed arm throughout the protocol.
   Conclusions: Exacerbation of OSS induced in vivo disturbances in platelet microparticle release, coagulation-fibrinolysis, and matrix metalloproteinase-9 activity in healthy individuals. These are potential mechanisms involved in OSS-mediated endothelial dysfunction.
C1 [Storch, Amanda Sampaio; Miguens Rocha, Helena Naly; Garcia, Vinicius Pacheco; da Silva Batista, Gabriel Matheus; Mattos, Joao Dario; Campos, Monique Opuszcka; Lucas da Nobrega, Antonio Claudio; Fernandes, Igor Alexandre; Rocha, Natalia Galito] Fluminense Fed Univ, Dept Physiol & Pharmacol, Lab Exercise Sci LACE, Rua Prof Hernani Pires de Melo 101,Sala 106, Niteroi, RJ, Brazil.
   [Fuly, Andre Lopes] Fluminense Fed Univ, Inst Biol, Dept Cellular & Mol Biol GCM, Outeiro Sao Joao Batista S-N, Niteroi, RJ, Brazil.
   [Lucas da Nobrega, Antonio Claudio; Rocha, Natalia Galito] Fluminense Fed Univ, Natl Council Sci & Technol Dev CNPq, Natl Inst Sci & Technol INCT Phys In Act & Exerci, Rua Prof Hernani Pires de Melo 101,Sala 106, Niteroi, RJ, Brazil.
   [Fernandes, Igor Alexandre] Univ Brasilia, Fac Phys Educ, NeuroVASQ Integrat Physiol Lab, BR-70910900 Brasilia, DF, Brazil.
C3 Universidade Federal Fluminense; Universidade Federal Fluminense;
   Universidade Federal Fluminense; Universidade de Brasilia
RP Rocha, NG (corresponding author), Fluminense Fed Univ, Dept Physiol & Pharmacol, Lab Exercise Sci, Rua Prof Hernani Pires de Melo 101,Sala 106, BR-24210130 Niteroi, RJ, Brazil.
EM asstorch@id.uff.br; hmiguens@id.uff.br; viniciuspg@id.uff.br;
   gabrielbatista@id.uff.br; joaodario@id.uff.br; andrefuly@id.uff.br;
   anobrega@id.uff.br; fernandes.igor@unb.br; nataliagalito@id.uff.br
RI Fuly, Andre/U-1538-2019; Pacheco Garcia, Vinicius/ABE-2776-2020; da
   Nobrega, Antonio/O-5107-2019; Mattos, João/AAD-4650-2019; Rocha, Natalia
   Galito/AAN-7903-2020; Rocha, Helena/B-9530-2018; Fernandes, Igor
   Alexandre/G-9589-2012; Storch, Amanda/G-9080-2017
OI Pacheco Garcia, Vinicius/0000-0003-3022-1616; Campos, Monique
   Opuszcka/0000-0001-9526-0937; Mattos, Joao Dario/0000-0002-7377-9348;
   Rocha, Natalia Galito/0000-0002-1990-9834; Rocha,
   Helena/0000-0002-4741-7343; Fernandes, Igor
   Alexandre/0000-0003-3873-2656; Storch, Amanda/0000-0003-4666-8359;
   Batista, Gabriel/0000-0002-1542-5242
FU Brazilian National Council of Scientific and Technological Development
   (CNPq) [Universal: 462265/2014-5]; oundation for Research Support of Rio
   de Janeiro (FAPERJ), Brazil [APQ 1: E-26/111.339/2014]; Coordination for
   the Improvement of Higher Education Personnel (CAPES), Brazil
FX This study was supported by grants from the Brazilian National Council
   of Scientific and Technological Development (CNPq; Universal:
   462265/2014-5); the Foundation for Research Support of Rio de Janeiro
   (FAPERJ), Brazil (APQ 1: E-26/111.339/2014); and the Coordination for
   the Improvement of Higher Education Personnel (CAPES), Brazil.
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NR 52
TC 14
Z9 15
U1 0
U2 4
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0049-3848
J9 THROMB RES
JI Thromb. Res.
PD OCT
PY 2018
VL 170
BP 119
EP 125
DI 10.1016/j.thromres.2018.08.019
PG 7
WC Hematology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Hematology; Cardiovascular System & Cardiology
GA GV6LG
UT WOS:000446221800017
PM 30172998
DA 2025-06-11
ER

PT J
AU Chielle, EO
   Casarin, JN
AF Chielle, Eduardo Ottobelli
   Casarin, Jeferson Noslen
TI Evaluation of salivary oxidative parameters in overweight and obese
   young adults
SO ARCHIVES OF ENDOCRINOLOGY METABOLISM
LA English
DT Article
DE Obesity; biomarkers; oxidative stress; saliva; antioxidants
ID SERUM URIC-ACID; METABOLIC-SYNDROME; INSULIN-RESISTANCE; OXIDANT STRESS;
   VITAMIN-E; ASSOCIATION; CARBONYL; RISK; MECHANISMS
AB Background: Obesity is characterized by a deposition of abnormal or excessive fat in adipose tissue, and is linked with a risk of damage to several metabolic and pathological processes associated with oxidative stress. To date, salivary oxidative biomarkers have been minimally explored in obese individuals. Thus, the aim of this study was to assess the concentrations of salivary oxidative biomarkers (ferric-reducing antioxidant power, uric acid, sulfhydryl groups) and lipid peroxidation in obese and overweight young subjects. Materials and methods: Levels of lipid peroxidation, ferric-reducing antioxidant power, uric acid, and SH groups were determined in the saliva and serum of 149 young adults, including 54 normal weight, 27 overweight, and 68 obese individuals. Anthropometric measurements were also evaluated. Results: Salivary levels of ferric-reducing antioxidant power, sulfhydryl groups, and lipid peroxidation, as well as serum levels of ferric-reducing antioxidant power, uric acid, and lipid peroxidation were higher in obese patients when compared with individuals with normal weight. There were correlations between salivary and serum ferric-reducing antioxidant power and salivary and serum uric acid in the obese and normal-weight groups. Conclusions: Our results indicate that the increase in salivary levels of ferric-reducing antioxidant power, sulfhydryl groups, and lipid peroxidation, and serum levels of ferric-reducing antioxidant power, uric acid, and lipid peroxidation could be related to the regulation of various processes in the adipose tissue. These findings may hold promise in identifying new oxidative markers to assist in diagnosing and monitoring overweight and obese patients.
C1 [Chielle, Eduardo Ottobelli; Casarin, Jeferson Noslen] Univ Oeste Santa Catarina Unoesc, Dept Ciencias Saude, Lab Bioquim Clin, Miguel Do Oeste, SC, Brazil.
C3 Universidade do Oeste de Santa Catarina
RP Chielle, EO (corresponding author), Rua Oiapoc 211, BR-89900000 Sao Miguel Do Oeste, SC, Brazil.
EM eduardochielle@yahoo.com.br
FU Brazilian National Research Council (CNPq); FAPE - UNOESC (Research
   Support Fund); University of West of Santa Catarina (UNOESC), SC, Brazil
FX the work had the financial support of the Brazilian National Research
   Council (CNPq), FAPE - UNOESC (Research Support Fund). The authors wish
   to thank the University of West of Santa Catarina (UNOESC), SC, Brazil,
   for support in this study.
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NR 41
TC 22
Z9 22
U1 0
U2 7
PU SBEM-SOC BRASIL ENDOCRINOLOGIA & METABOLOGIA
PI RIO DE JANEIRO, RJ
PA RUA HUMAITA, 85 CJ 501, RIO DE JANEIRO, RJ, 22261-000, BRAZIL
SN 2359-3997
EI 2359-4292
J9 ARCH ENDOCRIN METAB
JI Arch. Endocrinol. Metab.
PD APR
PY 2017
VL 61
IS 2
BP 152
EP 159
DI 10.1590/2359-3997000000227
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA ET8KJ
UT WOS:000400548000009
PM 27901184
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Valenzuela, R
   Illesca, P
   Echeverría, F
   Espinosa, A
   Rincón-Cervera, MA
   Ortiz, M
   Hernandez-Rodas, MC
   Valenzuela, A
   Videla, LA
AF Valenzuela, Rodrigo
   Illesca, Paola
   Echeverria, Francisca
   Espinosa, Alejandra
   Angel Rincon-Cervera, Miguel
   Ortiz, Macarena
   Catalina Hernandez-Rodas, Maria
   Valenzuela, Alfonso
   Videla, Luis A.
TI Molecular adaptations underlying the beneficial effects of
   hydroxytyrosol in the pathogenic alterations induced by a high-fat diet
   in mouse liver: PPAR-α and Nrf2 activation, and NF-κB down-regulation
SO FOOD & FUNCTION
LA English
DT Article
ID ENDOPLASMIC-RETICULUM STRESS; REDUCES OXIDATIVE STRESS; ACID N-6/N-3
   RATIO; OLIVE OIL; ADIPOSE-TISSUE; INSULIN-RESISTANCE; NONALCOHOLIC
   STEATOHEPATITIS; DESATURATION CAPACITY; EXTRAHEPATIC TISSUES; METABOLIC
   SYNDROME
AB Scope: Non-alcoholic fatty liver disease (NAFLD) is a condition characterized by an increment in the liver fat content, with a concomitant reduction in the content of n-3-long chain polyunsaturated fatty acids (n-3 LCPUFAs), downregulation of PPAR-alpha activity, and upregulation of NF-kappa B activity, effects that induce pro-lipogenic and pro-inflammatory responses. Hydroxytyrosol (HT), a polyphenol with cytoprotective effects present in extra virgin olive oil, improves the cellular antioxidant capacity for activation of transcription factor Nrf2. The objective of this work is to evaluate the molecular adaptations involved in the anti-lipogenic, anti-inflammatory, and anti-oxidant effects of HT supplementation in high-fat diet (HFD)-fed mice. Methods and results: Male C57BL/6J mice received (i) control diet (10% fat); (ii) control diet + HT (daily doses of 5 mg per kg body weight), (iii) HFD (60% fat); or (iv) HFD + HT for 12 weeks. HFD-fed mice exhibited (i) liver steatosis; (ii) inflammation; (iii) oxidative stress; and (iv) depletion of n-3 LCPUFAs, together with down-regulation of PPAR-alpha and Nrf2, and up-regulation of NF-kappa B. HT supplementation attenuated the metabolic alterations produced by HFD, normalizing the activity of Nrf2, reducing the drop in activity of PPAR-alpha, and attenuating increment of NF-kappa B activation. Conclusion: Supplementation with HT activating transcription factors PPAR-alpha and Nrf2, along with the deactivation of NF-kappa B, may reduce the liver alterations induced in HFD-fed mice.
C1 [Valenzuela, Rodrigo; Echeverria, Francisca; Ortiz, Macarena; Catalina Hernandez-Rodas, Maria] Univ Chile, Dept Nutr, Fac Med, Santiago, Chile.
   [Valenzuela, Rodrigo; Angel Rincon-Cervera, Miguel; Valenzuela, Alfonso] Univ Chile, Inst Nutr & Food Technol INTA, Lipid Ctr, Santiago, Chile.
   [Illesca, Paola] Univ Litoral, Fac Biochem, Biochem Dept, Santa Fe, Argentina.
   [Espinosa, Alejandra] Univ Chile, Med Technol Dept, Fac Med, Santiago, Chile.
   [Videla, Luis A.] Univ Chile, Inst Biomed Sci, Mol & Clin Pharmacol Program, Fac Med, Santiago, Chile.
C3 Universidad de Chile; Universidad de Chile; National University of the
   Littoral; Universidad de Chile; Universidad de Chile
RP Valenzuela, R (corresponding author), Univ Chile, Dept Nutr, Fac Med, Santiago, Chile.; Valenzuela, R (corresponding author), Univ Chile, Inst Nutr & Food Technol INTA, Lipid Ctr, Santiago, Chile.
EM rvalenzuelab@med.uchile.cl
RI Espinosa, Alejandra/ISB-7050-2023; Valenzuela-Garcia, Jesus/L-2982-2017;
   Hernández-Rodas, María/ABG-5275-2021; Echeverría,
   Francisca/ISV-5437-2023; Cervera, Miguel/C-2473-2015; Illesca,
   Paola/IVH-6615-2023; Echeverria, Francisca/M-3207-2018
OI Illesca, Paola/0000-0002-8491-2458; Hernandez Rodas, Maria
   Catalina/0000-0001-9516-4056; Echeverria, Francisca/0000-0002-9661-0377
FU FONDECYT (National Fund for Scientific and Technological Development,
   Research Initiation Program) [11140174]
FX The authors are grateful to the grant (11140174) from FONDECYT (National
   Fund for Scientific and Technological Development, Research Initiation
   Program) to R. V. for supporting this study.
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NR 60
TC 109
Z9 111
U1 1
U2 33
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PD APR 1
PY 2017
VL 8
IS 4
BP 1526
EP 1537
DI 10.1039/c7fo00090a
PG 12
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA ES8JY
UT WOS:000399804500015
PM 28386616
DA 2025-06-11
ER

PT J
AU Xu, YZ
   Wang, Q
   Cui, RT
   Lu, KL
   Liu, YL
   Zhao, YW
AF Xu, Yuzhen
   Wang, Qian
   Cui, Ruiting
   Lu, Kaili
   Liu, Yunlin
   Zhao, Yuwu
TI Uric acid is associated with vascular dementia in Chinese population
SO BRAIN AND BEHAVIOR
LA English
DT Article
DE oxidative stress; uric acid; vascular dementia
ID ONSET ALZHEIMERS-DISEASE; MENTAL-STATE-EXAMINATION; OXIDATIVE STRESS;
   COGNITIVE IMPAIRMENT; METABOLIC SYNDROME; ISCHEMIC-STROKE;
   ARTERY-DISEASE; OLDER PATIENTS; RISK; DECLINE
AB Objective: Mounting evidence suggests that oxidative stress is involved in the pathogenesis of vascular dementia (VD). Uric acid (UA) has long been implicated as a critical cause of cardiovascular disease. Nevertheless, UA was also expected to play an important role in antioxidant and neuroprotection recently. We hypothesized that UA may have a protective role against VD. The aim of this study was to investigate the link between serum UA and cognitive dysfunction in VD.
   Materials and Methods: There were altogether 127 VD subjects and 81 nondemented controls enrolled in our study. Serum UA, demographic, and clinical characteristics were recorded at baseline, and all participants underwent Mini-Mental State Examination (MMSE) at the beginning of the trial.
   Results: The VD group showed lower MMSE scores and serum UA levels than nondemented controls and there was significant statistical difference between the two groups (p < .05). Demographic and clinical characteristics such as age, gender, education, body mass index (BMI), total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL), low-density lipoprotein cholesterol (LDL), blood urea nitrogen (BUN), and serum creatinine (Scr) did not differ dramatically between groups (p > .05). In VD subjects, there was a positive correlation between serum UA and MMSE scores (r = .32, p < .05), and this correlation was independent of demographic and clinical characteristics (beta = .272, p < .05).
   Conclusions: VD subjects have dramatically lower serum UA levels in comparison to nondemented controls. Lower serum UA levels are linked to cognitive dysfunction and could serve as a potential predictor for VD.
C1 [Xu, Yuzhen; Lu, Kaili; Zhao, Yuwu] Shanghai Jiao Tong Univ, Dept Neurol, Affiliated Peoples Hosp 6, Shanghai, Peoples R China.
   [Wang, Qian] Taishan Med Univ, Dept Cent Lab, Affiliated Taishan Hosp, Tai An, Shandong, Peoples R China.
   [Cui, Ruiting; Liu, Yunlin] Taishan Med Univ, Dept Neurol, Affiliated Taishan Hosp, Tai An, Shandong, Peoples R China.
C3 Shanghai Jiao Tong University; Shandong First Medical University &
   Shandong Academy of Medical Sciences; Taishan University; Taishan
   University; Shandong First Medical University & Shandong Academy of
   Medical Sciences
RP Zhao, YW (corresponding author), Shanghai Jiao Tong Univ, Dept Neurol, Affiliated Peoples Hosp 6, Shanghai, Peoples R China.; Liu, YL (corresponding author), Taishan Med Univ, Dept Neurol, Affiliated Taishan Hosp, Tai An, Shandong, Peoples R China.
EM tadoctor@126.com; zhao_yuwu2005@126.com
RI Xu, Yuzhen/X-4405-2019
OI Wang, Qian/0000-0002-5031-0686
FU Department of Neurology; Department of Neurology, Taishan Medical
   University Affiliated Taishan Hospital; National Natural Science
   Foundation of China [31271125]
FX We are deeply indebted to the Department of Neurology, Taishan Medical
   University Affiliated Taishan Hospital for their kind help. The study
   was supported by National Natural Science Foundation of China
   (31271125).
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NR 41
TC 23
Z9 24
U1 0
U2 16
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 2162-3279
J9 BRAIN BEHAV
JI Brain Behav.
PD FEB
PY 2017
VL 7
IS 2
AR e00617
DI 10.1002/brb3.617
PG 6
WC Behavioral Sciences; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Behavioral Sciences; Neurosciences & Neurology
GA EM9KR
UT WOS:000395630900013
PM 28239527
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Miricescu, D
   Totan, A
   Calenic, B
   Mocanu, B
   Didilescu, A
   Mohora, M
   Spinu, T
   Greabu, M
AF Miricescu, Daniela
   Totan, Alexandra
   Calenic, Bogdan
   Mocanu, Brandusa
   Didilescu, Andreea
   Mohora, Maria
   Spinu, Tudor
   Greabu, Maria
TI Salivary biomarkers: Relationship between oxidative stress and alveolar
   bone loss in chronic periodontitis
SO ACTA ODONTOLOGICA SCANDINAVICA
LA English
DT Article
DE biomarkers; bone resorption; chronic periodontitis; saliva
ID METABOLIC SYNDROME; POSSIBLE MARKERS; PROTEIN; ANTIOXIDANTS; GINGIVAL;
   DISEASE; SERUM
AB Objectives. Oxidative stress is implicated in the pathogenesis of many systemic and oral diseases such as periodontal disease. The main aim of this study is to explore a possible association between salivary markers of OS and alveolar bone loss. Materials and methods. The study included 20 patients with chronic periodontitis and 20 controls. Salivary OS biomarkers 8-hidroxy-desoxguanosine (8-HOdG), malondialdehyde (MDA), uric acid, total antioxidant capacity (TAC) and glutathione peroxidase (GPx) were evaluated. Bone loss markers such as C-terminal telopeptide of type I collagen (CTX I), matrix metalloproteinases-8 (MMP-8), osteocalcin and 25-hydroxy vitamin D-3 (25-OH D) were detected in this study. The methods included general biochemical tests and ELISA. Results. Salivary 8-OHdG, MDA levels were significantly higher in the chronic periodontitis group compared with controls (p < 0.05). Salivary activities for uric acid, TAC and GPx were significantly decreased in patients with chronic periodontitis vs controls (p < 0.05). Salivary levels for CTX I, MMP-8, 25-OH D and Osteocalcin were significantly higher in the chronic periodontitis group compared to the controls (p < 0.05). A significant positive correlation was observed between salivary levels of MDA and CTX I. Significant negative correlations between uric acid and CTX I and between MMP-8 and uric acid have been found. Significant positive correlations were observed between CTX I, MMP-8, 25-OH D, osteocalcin and clinical parameters of periodontal disease. Conclusions. Important oxidative stress associated with alveolar bone loss biomarkers can be detected in saliva of patients with periodontal disease.
C1 [Miricescu, Daniela; Totan, Alexandra; Calenic, Bogdan; Greabu, Maria] Univ Med & Pharm, Fac Med Dent, Dept Biochem, Bucharest, Romania.
   [Mocanu, Brandusa] Univ Med & Pharm, Fac Med Dent, Dept Periodontol, Bucharest, Romania.
   [Didilescu, Andreea] Univ Med & Pharm, Fac Med Dent, Dept Embriol, Bucharest, Romania.
   [Mohora, Maria] Univ Med & Pharm, Fac Gen Med, Dept Biochem, Bucharest, Romania.
   [Spinu, Tudor] Univ Med & Pharm, Fac Med Dent, Dept Fixed Prosthodont & Occlus, Bucharest, Romania.
C3 Carol Davila University of Medicine & Pharmacy; Carol Davila University
   of Medicine & Pharmacy; Carol Davila University of Medicine & Pharmacy;
   Carol Davila University of Medicine & Pharmacy; Carol Davila University
   of Medicine & Pharmacy
RP Calenic, B (corresponding author), 8 Blvd Eroii Sanit, Bucharest, Romania.
EM bcalenic@yahoo.co.uk
RI Ripszky-Totan, Alexandra/JTT-4320-2023; Spinu, Tudor
   Claudiu/GON-8485-2022; Greabu, Maria/Q-9336-2019; Daniela,
   Miricescu/G-8788-2016; Didilescu, Andreea/K-1135-2019
OI Didilescu, Andreea/0000-0002-2915-5124; Ripszky,
   Alexandra/0000-0002-4345-282X
FU Sectorial Operational Programme Human Programme Human Resources
   Development (SOP HRD); European Social Fund and by the Romanian
   Government [POSDRU/6/1.5/S/S17]
FX This study was supported by the Sectorial Operational Programme Human
   Programme Human Resources Development (SOP HRD), financed from the
   European Social Fund and by the Romanian Government under the contract
   number POSDRU/6/1.5/S/S17.
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NR 40
TC 112
Z9 117
U1 1
U2 39
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0001-6357
EI 1502-3850
J9 ACTA ODONTOL SCAND
JI Acta Odontol. Scand.
PD JAN
PY 2014
VL 72
IS 1
BP 42
EP 47
DI 10.3109/00016357.2013.795659
PG 6
WC Dentistry, Oral Surgery & Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dentistry, Oral Surgery & Medicine
GA 280VG
UT WOS:000329058300006
PM 23869629
DA 2025-06-11
ER

PT J
AU Jung, TS
   Kim, SK
   Shin, HJ
   Jeon, BT
   Hahm, JR
   Roh, GS
AF Jung, Tae Sik
   Kim, Soo Kyoung
   Shin, Hyun Joo
   Jeon, Byeong Tak
   Hahm, Jong Ryeal
   Roh, Gu Seob
TI α-lipoic acid prevents non-alcoholic fatty liver disease in OLETF rats
SO LIVER INTERNATIONAL
LA English
DT Article
DE diabetes; non-alcoholic fatty liver disease; obesity; OLETF; a-lipoic
   acid
ID ACTIVATED PROTEIN-KINASE; INSULIN-RESISTANCE; HEME OXYGENASE-1;
   METABOLIC SYNDROME; OXIDATIVE STRESS; OBESE RATS; STEATOHEPATITIS;
   HEPATOCYTES; PATHOGENESIS; ASSOCIATION
AB Background Insulin resistance, oxidative stress, inflammation and innate immune system activation contribute to the development of non-alcoholic fatty liver disease (NAFLD) through steatosis and inflammation in the liver. The powerful antioxidant a-lipoic acid (ALA) has been shown to improve insulin sensitivity and suppress inflammatory responses. This study explores how ALA administration protects against NAFLD. Methods Otsuka Long-Evans Tokushima Fatty (OLETF) rats were divided into two groups (treated with 200 mg/kg/day of ALA or untreated) at 12 weeks of age and sacrificed at 28 weeks of age. Results Serum levels of insulin, free fatty acids, total cholesterol, triglyceride, leptin, IL-6 and blood glucose were decreased in ALA-treated rats. Serum adiponectin levels were higher in ALA-treated rats. ALA treatment decreased the expression of sterol regulatory element binding protein-1 and acetyl CoA carboxylase, and increased glucose transporter-4 expression in the livers of OLETF rats. Expression of the antioxidant enzymes heme oxygenase-1 and Cu/Zn-superoxide dismutase was increased in the livers of ALA-treated rats. The lipid peroxidation marker 4-hydroxynonenal was decreased in the liver of ALA-treated rats. Proteins associated with innate immune activation (Toll-like receptor-4 and high-mobility group protein box-1) and inflammatory markers (vascular cell adhesion molecule-1, intercellular adhesion molecule-1, and cyclooxygenase-2) were decreased in the livers of ALA-treated rats. Conclusions Chronic ALA supplementation prevents NAFLD through multiple mechanisms by reducing steatosis, oxidative stress, immune activation and inflammation in the liver.
C1 [Shin, Hyun Joo; Jeon, Byeong Tak; Roh, Gu Seob] Gyeongsang Natl Univ Sch Med, Dept Anat & Neurobiol, Inst Hlth Sci, Jinju 660290, Gyeongnam, South Korea.
   [Jung, Tae Sik; Kim, Soo Kyoung; Hahm, Jong Ryeal] Gyeongsang Natl Univ Sch Med, Dept Internal Med, Inst Hlth Sci, Jinju 660290, Gyeongnam, South Korea.
C3 Gyeongsang National University; Gyeongsang National University
RP Roh, GS (corresponding author), Gyeongsang Natl Univ Sch Med, Dept Anat & Neurobiol, Inst Hlth Sci, 816 Beongil 15 Jinju Daero, Jinju 660290, Gyeongnam, South Korea.
EM anaroh@gnu.ac.kr
FU Ministry of Health & Welfare, Republic of Korea [A111436]; Gyeongsang
   National University Hospital [GNUHCRF-2011-008]
FX This study was supported by a grant from the Korean Health Technology
   R&D Project, Ministry of Health & Welfare, Republic of Korea (A111436)
   and partially supported by a special clinical fund (GNUHCRF-2011-008)
   from the Gyeongsang National University Hospital. We thank the Otsuka
   Pharmaceutical Company (Tokushima, Japan) for donating LETO and OLETF
   rats. There are no conflicts of interest.
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NR 40
TC 46
Z9 52
U1 0
U2 14
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1478-3223
EI 1478-3231
J9 LIVER INT
JI Liver Int.
PD NOV
PY 2012
VL 32
IS 10
BP 1565
EP 1573
DI 10.1111/j.1478-3231.2012.02857.x
PG 9
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 015MA
UT WOS:000309448900013
PM 22863080
OA Bronze
DA 2025-06-11
ER

PT J
AU Castanon-Cervantes, O
   Wu, MW
   Ehlen, JC
   Paul, K
   Gamble, KL
   Johnson, RL
   Besing, RC
   Menaker, M
   Gewirtz, AT
   Davidson, AJ
AF Castanon-Cervantes, Oscar
   Wu, Mingwei
   Ehlen, J. Christopher
   Paul, Ketema
   Gamble, Karen L.
   Johnson, Russell L.
   Besing, Rachel C.
   Menaker, Michael
   Gewirtz, Andrew T.
   Davidson, Alec J.
TI Dysregulation of Inflammatory Responses by Chronic Circadian Disruption
SO JOURNAL OF IMMUNOLOGY
LA English
DT Article
ID CHRONIC JET-LAG; SLEEP-DEPRIVATION; SHIFT WORK; SUPRACHIASMATIC NUCLEUS;
   SIBERIAN HAMSTERS; LETHAL ENDOTOXEMIA; PERIPHERAL-TISSUES; METABOLIC
   SYNDROME; IMMUNE-RESPONSES; PROSTATE-CANCER
AB Circadian rhythms modulate nearly every mammalian physiological process. Chronic disruption of circadian timing in shift work or during chronic jet lag in animal models leads to a higher risk of several pathologies. Many of these conditions in both shift workers and experimental models share the common risk factor of inflammation. In this study, we show that experimentally induced circadian disruption altered innate immune responses. Endotoxemic shock induced by LPS was magnified, leading to hypothermia and death after four consecutive weekly 6-h phase advances of the light/dark schedule, with 89% mortality compared with 21% in unshifted control mice. This may be due to a heightened release of proinflammatory cytokines in response to LPS treatment in shifted animals. Isolated peritoneal macrophages harvested from shifted mice exhibited a similarly heightened response to LPS in vitro, indicating that these cells are a target for jet lag. Sleep deprivation and stress are known to alter immune function and are potential mediators of the effects we describe. However, polysomnographic recording in mice exposed to the shifting schedule revealed no sleep loss, and stress measures were not altered in shifted mice. In contrast, we observed altered or abolished rhythms in the expression of clock genes in the central clock, liver, thymus, and peritoneal macrophages in mice after chronic jet lag. We conclude that circadian disruption, but not sleep loss or stress, are associated with jet lag-related dysregulation of the innate immune system. Such immune changes might be a common mechanism for the myriad negative health effects of shift work. The Journal of Immunology, 2010, 185: 5796-5805.
C1 [Davidson, Alec J.] Morehouse Sch Med, Circadian Rhythms & Sleep Disorders Program, Inst Neurosci, Atlanta, GA 30310 USA.
   [Gamble, Karen L.; Johnson, Russell L.] Univ Alabama, Dept Psychiat & Behav Neurobiol, Birmingham, AL 35205 USA.
   [Gamble, Karen L.; Johnson, Russell L.] Univ Alabama, Dept Psychol, Birmingham, AL 35205 USA.
   [Menaker, Michael] Univ Virginia, Dept Biol, Charlottesville, VA 22908 USA.
   [Gewirtz, Andrew T.] Emory Univ, Dept Pathol, Atlanta, GA 30322 USA.
C3 Morehouse School of Medicine; University of Alabama System; University
   of Alabama Birmingham; University of Alabama System; University of
   Alabama Birmingham; University of Virginia; Emory University
RP Davidson, AJ (corresponding author), Morehouse Sch Med, Circadian Rhythms & Sleep Disorders Program, Inst Neurosci, 720 Westview Dr SW, Atlanta, GA 30310 USA.
EM adavidson@msm.edu
RI Gamble, Karen/A-1753-2010; Ehlen, Christopher/GXV-9278-2022; Gewirtz,
   Andrew/HCH-2932-2022
OI Davidson, Alec/0000-0003-4205-1968; Ehlen, J.
   Christopher/0000-0003-3223-9262; Gamble, Karen/0000-0003-3813-8577
FU National Institutes of Health [5U54NS-060659-020001, P20CA132389,
   GM086683]; National Institutes of Health/National Center for Research
   Resources/Research Centers in Minority Institutions [G12-RR03034];
   National Institutes of Health/National Center on Minority Health and
   Health Disparities [5S21MD000101-09]; Georgia Research Alliance;
   National Science Foundation Center for Behavioral Neuroscience
FX This work was supported in part by National Institutes of Health Grants
   5U54NS-060659-020001 and P20CA132389 (to A.J.D.) and GM086683 (to K. L.
   G.), National Institutes of Health/National Center for Research
   Resources/Research Centers in Minority Institutions Grant G12-RR03034,
   National Institutes of Health/National Center on Minority Health and
   Health Disparities Grant 5S21MD000101-09, the Georgia Research Alliance,
   and the National Science Foundation Center for Behavioral Neuroscience.
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NR 86
TC 416
Z9 480
U1 3
U2 62
PU AMER ASSOC IMMUNOLOGISTS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-1767
J9 J IMMUNOL
JI J. Immunol.
PD NOV 15
PY 2010
VL 185
IS 10
BP 5796
EP 5805
DI 10.4049/jimmunol.1001026
PG 10
WC Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology
GA 675RJ
UT WOS:000283848000017
PM 20944004
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Nelson, RG
AF Nelson, Robin G.
TI Adult Health Outcomes and Their Implications for Experiences of
   Childhood Nutritional Stress in Jamaica
SO AMERICAN JOURNAL OF HUMAN BIOLOGY
LA English
DT Article; Proceedings Paper
CT Symposium on Integrative Approaches to the Study of Human Adaptation and
   Population Health
CY APR 11, 2008
CL Columbus, OH
ID BODY-MASS INDEX; SOCIOECONOMIC-STATUS; DEVELOPMENTAL ORIGINS; METABOLIC
   SYNDROME; BLOOD-PRESSURE; FETAL ORIGINS; OBESITY; OVERWEIGHT; WOMEN;
   DISEASE
AB With insights from the developmental origins of health and disease paradigm (DOHaD), this study explores the impact of childhood nutritional stress on adult health outcomes in Jamaica. Jamaica experienced a lengthy period of political and economic instability beginning in the postcolonial period of the early 1960s. This study tests whether decreased government spending on public resources and limited access to imported food products during the early postcolonial period will be reflected in increased adiposity and body mass index among Jamaican adults. Ethnographic and anthropometric data were collected from individuals born between 1958 and 1988. Variability in health outcomes was assessed using Z-score values for body mass index and summed skinfold thickness measures. Age was employed as both a continuous and categorical independent variable. In partial correlation models controlling for economic status, body mass index values and summed skinfold thickness increased with age. Birth cohort and gender effects were also apparent. Women born between 1959 and 1968 had higher body mass index Z-score values than younger women. Both men and women born between 1959 and 1968 had significantly higher skinfold thickness measures than younger individuals. Individuals born between 1959 and 1968 were children during the immediate postcolonial era in Jamaica. Experiences of nutritional stress during critical developmental periods may have contributed to the observed age-related increases in adipose tissue and body mass index values. This study informs our understanding of the ways that fluctuations in the sociopolitical environment during development can mediate and contribute to poor adult health outcomes. Am. J. Hum. Biol. 21:671-678, 2009. (C) 2009 Wiley-Liss, Inc.
C1 Northwestern Univ, Dept Anthropol, Evanston, IL 60208 USA.
C3 Northwestern University
RP Nelson, RG (corresponding author), Northwestern Univ, Dept Anthropol, Evanston, IL 60208 USA.
EM robin-nelson@northwestern.edu
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NR 79
TC 6
Z9 9
U1 0
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1042-0533
EI 1520-6300
J9 AM J HUM BIOL
JI Am. J. Hum. Biol.
PD SEP-OCT
PY 2009
VL 21
IS 5
BP 671
EP 678
DI 10.1002/ajhb.20963
PG 8
WC Anthropology; Biology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI); Conference Proceedings Citation Index - Social Science &amp; Humanities (CPCI-SSH); Conference Proceedings Citation Index - Science (CPCI-S)
SC Anthropology; Life Sciences & Biomedicine - Other Topics
GA 486BH
UT WOS:000269169900011
PM 19533609
DA 2025-06-11
ER

PT J
AU Câmara, N
   Sierra, E
   Fernández, A
   Arbelo, M
   de Quirós, YB
   Arregui, M
   Consoli, F
   Herráez, P
AF Camara, Nakita
   Sierra, Eva
   Fernandez, Antonio
   Arbelo, Manuel
   de Quiros, Yara
   Arregui, Marina
   Consoli, Francesco
   Herraez, Pedro
TI Capture Myopathy and Stress Cardiomyopathy in a Live-Stranded Risso's
   Dolphin (Grampus griseus) in Rehabilitation
SO ANIMALS
LA English
DT Article
DE animal conservation; animal welfare; cetaceans; biochemistry;
   histopathology; immunohistochemistry
ID RHABDOMYOLYSIS
AB Simple Summary Free-living cetaceans are threatened, daily, by a wide variety of stressful situations. An example is provided by live-stranding, in which a cetacean is alive on the beach or in shallow water, and unable to free itself and resume its normal activity. This is the first case of capture myopathy and stress cardiomyopathy in a live-stranded juvenile male Risso's dolphin (Grampus griseus) with subsequent rehabilitation attempted. Valuable use of blood samples, and finally necropsy assessments, advances our understanding about the pathology common in live-stranded cetaceans. Capture myopathy (CM) is described in wild animals as a metabolic syndrome resulting from the extreme stress suffered during and after capture, handling, restraint, and transport. Although CM has been characterized in many species of cetaceans, descriptions of cardiac injury-an important component of this syndrome, and, according to previous authors, comparable to the existing human pathology so-called stress cardiomyopathy (SCMP)-are still rare. Therefore, the main aim of this report is to illustrate, for the first time, the biochemical analysis, and gross, histopathological, histochemical and immunohistochemical features of CM, and more specifically of the SCMP involved in this syndrome, caused by the live-stranding and consequent rehabilitation attempt, for a certain period of time, in a juvenile male Risso's dolphin (Grampus griseus). The animal presented elevated values of creatine kinase, cardiac troponin I and blood urea nitrogen, with some variations during the rehabilitation period. Histologically, we detected vascular changes and acute degenerative lesions analogous to the ones observed in humans with SCMP. We consider this study to be an important contribution to the study of cetaceans since it could help in decision-making and treatment procedures during live-strandings and improve conservation efforts by reducing the mortality of these animals.
C1 [Camara, Nakita; Sierra, Eva; Fernandez, Antonio; Arbelo, Manuel; de Quiros, Yara; Arregui, Marina; Consoli, Francesco; Herraez, Pedro] Univ Las Palmas Gran Canaria, Sch Vet, Inst Anim Hlth & Food Safety IUSA, Vet Histol & Pathol, Arucas 35416, Las Palmas De G, Spain.
   [Consoli, Francesco] Univ G DAnnunzio, Dept Neurosci Imaging & Clin Sci, I-66100 Chieti, Italy.
C3 Universidad de Las Palmas de Gran Canaria; G d'Annunzio University of
   Chieti-Pescara
RP Sierra, E (corresponding author), Univ Las Palmas Gran Canaria, Sch Vet, Inst Anim Hlth & Food Safety IUSA, Vet Histol & Pathol, Arucas 35416, Las Palmas De G, Spain.
EM kita_camara@hotmail.com; eva.sierra@ulpgc.es;
   antonio.fernandez@ulpgc.es; manuel.arbelo@ulpgc.es;
   marina.arregui@ulpgc.es; marina.arregui@ulpgc.es;
   francesco.consoli@studio.unibo.it; pedro.herraez@ulpgc.es
RI Arregui, Marina/ABI-7732-2020; Fernandez, Antonio/G-3448-2015; Bernaldo
   de Quiros, Yara/A-3628-2015; Arbelo Hernandez, Manuel/D-6789-2013;
   Sierra, Eva/H-9352-2015; Camara, Nakita/P-8624-2019
OI Fernandez, Antonio/0000-0001-5281-0521; Bernaldo de Quiros,
   Yara/0000-0002-2611-0406; Arbelo Hernandez, Manuel/0000-0002-1623-5010;
   Herraez, Pedro/0000-0001-9316-2882; Sierra, Eva/0000-0003-3749-8845;
   Camara, Nakita/0000-0001-8307-3915; Arregui, Marina/0000-0002-5954-0322
FU Ministry of Economy and Competitiveness (MINECO) [BES-2016-076907];
   MINECO [CGL2015-71498-P, CABILDO2018: CABILDO2018-04]; Canary Islands
   Government
FX This study is part of a PhD thesis supported by the Ministry of Economy
   and Competitiveness (MINECO) through a predoctoral grant
   BES-2016-076907. Furthermore, part of this research work was supported
   through the Research Projects (MINECO, CGL2015-71498-P and CABILDO2018:
   CABILDO2018-04). Moreover, the Canary Islands Government funded and
   provided support to the stranding research network.
CR Arbelo M, 2013, DIS AQUAT ORGAN, V103, P87, DOI 10.3354/dao02558
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NR 31
TC 14
Z9 14
U1 0
U2 9
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 2076-2615
J9 ANIMALS-BASEL
JI Animals
PD FEB
PY 2020
VL 10
IS 2
AR 220
DI 10.3390/ani10020220
PG 10
WC Agriculture, Dairy & Animal Science; Veterinary Sciences; Zoology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture; Veterinary Sciences; Zoology
GA KW7IE
UT WOS:000521356600017
PM 32013196
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Rakic, D
   Jakovljevic, V
   Zivkovic, V
   Uzelac, JJ
   Jovic, N
   Muric, M
   Pindovic, B
   Dimitrijevic, A
   Arsenijevic, P
   Rakic, J
   Mitrovic, S
   Vulovic, T
   Jovic, JJ
AF Rakic, Dejana
   Jakovljevic, Vladimir
   Zivkovic, Vladimir
   Jakovljevic Uzelac, Jovana
   Jovic, Nikola
   Muric, Maja
   Pindovic, Bozidar
   Dimitrijevic, Aleksandra
   Arsenijevic, Petar
   Rakic, Jovan
   Mitrovic, Slobodanka
   Vulovic, Tatjana
   Joksimovic Jovic, Jovana
TI Multiple Benefits of Empagliflozin in PCOS: Evidence from a Preclinical
   Rat Model
SO PATHOPHYSIOLOGY
LA English
DT Article
DE polycystic ovary syndrome; metformin; empagliflozin; rats;
   sodium-glucose cotransporter type 2 inhibitors; metabolic syndrome;
   reproduction
ID POLYCYSTIC-OVARY-SYNDROME; SELECTIVE INHIBITOR; INSULIN-RESISTANCE;
   OXIDATIVE STRESS; BODY-WEIGHT; METFORMIN; DAPAGLIFLOZIN; DIAGNOSIS;
   EFFICACY; CRITERIA
AB Polycystic ovary syndrome (PCOS) is the most common complex endocrinological condition of women that is associated with infertility and metabolic disorders during the reproductive period. Recently, a great deal of research has focused on the etiopathogenesis of this disorder and the modulation of therapeutic approaches. There are still many controversies in the choice of therapy, and metformin is one of the most commonly used agents in the treatment of PCOS. Considering the link between metabolic disorders and PCOS, glycemic status is crucial in these patients, and sodium-glucose cotransporter type 2 inhibitors (SGLT2is) represent a potentially promising new therapeutic approach. These drugs have been shown to improve glucose metabolism, reduce adipose tissue, decrease oxidative stress, and protect the cardiovascular system. These data prompted us to investigate the effects of empagliflozin (EMPA) in a PCOS rat model and compare them with the effects of metformin. We confirmed that EMPA positively affects somatometric parameters, glucose and lipid metabolism, and the levels of sex hormones, as well as reduces oxidative stress and improves ovarian function and morphology. Administration of EMPA at doses of 5 mg/kg, 15 mg/kg, and 45 mg/kg during a 4-week treatment period improved, as induced by estradiol valerate and a high-fat diet, the metabolic and reproductive statuses in a PCOS rat model. The best effects, which were comparable to the effects of metformin, were achieved in groups receiving the middle and highest applied doses of EMPA. These results may prompt further clinical research on the use of EMPA in patients with PCOS.
C1 [Rakic, Dejana; Jovic, Nikola; Dimitrijevic, Aleksandra; Arsenijevic, Petar] Univ Kragujevac, Fac Med Sci, Dept Gynecol & Obstet, Kragujevac 34000, Serbia.
   [Rakic, Dejana; Jovic, Nikola; Muric, Maja; Dimitrijevic, Aleksandra; Arsenijevic, Petar; Mitrovic, Slobodanka; Vulovic, Tatjana] Univ Clin Ctr Kragujevac, Zmaj Jovina 30, Kragujevac 34000, Serbia.
   [Jakovljevic, Vladimir; Zivkovic, Vladimir; Muric, Maja; Pindovic, Bozidar; Joksimovic Jovic, Jovana] Univ Kragujevac, Fac Med Sci, Dept Pharm, Kragujevac 34000, Serbia.
   [Jakovljevic, Vladimir; Zivkovic, Vladimir; Joksimovic Jovic, Jovana] Cardiovasc & Metab Disorders, Kragujevac, Serbia.
   [Jakovljevic, Vladimir] IM Sechenov First Moscow State Med Univ, Sechenov Univ, Moscow 119146, Russia.
   [Zivkovic, Vladimir] IM Sechenov First Moscow State Med Univ, Dept Pharmacol, Moscow 119435, Russia.
   [Jakovljevic Uzelac, Jovana] Univ Belgrade, Inst Med Physiol Richard Burian, Fac Med, Belgrade 11000, Serbia.
   [Pindovic, Bozidar] Univ Kragujevac, Fac Med Sci, Dept Pharm, Kragujevac 34000, Serbia.
   [Rakic, Jovan] Univ Kragujevac, Fac Med Sci, Dept Dent, Kragujevac 34000, Serbia.
   [Mitrovic, Slobodanka] Univ Kragujevac, Fac Med Sci, Dept Pathol, Kragujevac 34000, Serbia.
   [Vulovic, Tatjana] Univ Kragujevac, Fac Med Sci, Dept Surg, Kragujevac 34000, Serbia.
C3 University of Kragujevac; University of Kragujevac; Sechenov First
   Moscow State Medical University; Sechenov First Moscow State Medical
   University; University of Belgrade; University of Kragujevac; University
   of Kragujevac; University of Kragujevac; University of Kragujevac
RP Jovic, JJ (corresponding author), Univ Kragujevac, Fac Med Sci, Dept Pharm, Kragujevac 34000, Serbia.; Jovic, JJ (corresponding author), Cardiovasc & Metab Disorders, Kragujevac, Serbia.
EM dejavulovic@gmail.com; drvladakgbg@yahoo.com; vladimirziv@gmail.com;
   jovanavjakovljevic@gmail.com; docctorny@gmail.com;
   majanikolickg90@gmail.com; pindovic.bozidar@gmail.com;
   saskadkg@gmail.com; petar.arsenijevic@yahoo.com; rakic999@hotmail.com;
   smitrovic@medf.kg.ac.rs; tatjana_vulovic@yahoo.com;
   jovana_joksimovic@yahoo.com
RI Zivkovic, Vladimir/AAP-6213-2020; mitrovic, slobodanka/I-7732-2019;
   Dimitrijevic, Aleksandra/AFW-3053-2022; Jakovljevic,
   Vladimir/V-1583-2019
OI Joksimovic, Jovana/0000-0001-9625-0626; Pindovic,
   Bozidar/0009-0000-7603-5865
FU Junior Project Faculty of Medical Sciences, University of Kragujevac,
   Serbia;  [12/22]
FX This research was funded by the Junior Project Faculty of Medical
   Sciences, University of Kragujevac, Serbia, Junior Project number 12/22.
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NR 82
TC 2
Z9 2
U1 2
U2 2
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 0928-4680
EI 1873-149X
J9 PATHOPHYSIOLOGY-BASE
JI Pathophysiology
PD DEC
PY 2024
VL 31
IS 4
BP 559
EP 582
DI 10.3390/pathophysiology31040041
PG 24
WC Pathology
WE Emerging Sources Citation Index (ESCI)
SC Pathology
GA Q3X0T
UT WOS:001384041300001
PM 39449523
OA gold
DA 2025-06-11
ER

PT J
AU Chen, WY
   Tumanov, S
   Fazarkeley, D
   Cantley, J
   James, DE
   Dunn, LL
   Shaik, T
   Suarna, C
   Stocker, R
AF Chen, Weiyu
   Tumanov, Sergey
   Fazarkeley, Daniel
   Cantley, James
   James, David E.
   Dunn, Louise L.
   Shaik, Taqi
   Suarna, Cacang
   Stocker, Roland
TI Bilirubin deficiency renders mice susceptible to hepatic steatosis in
   the absence of insulin resistance
SO REDOX BIOLOGY
LA English
DT Article
DE Bilirubin; Insulin signaling; Lipid oxidation; F-2-isoprostanes; Vitamin
   E
ID NONALCOHOLIC FATTY LIVER; HUMAN BILIVERDIN REDUCTASE; METABOLIC
   SYNDROME; VITAMIN-E; SERUM BILIRUBIN; OXIDATIVE STRESS; DISEASE; DIET;
   RISK; SENSITIVITY
AB Background & aims: Plasma concentrations of bilirubin, a product of heme catabolism formed by biliverdin reductase A (BVRA), inversely associate with the risk of metabolic diseases including hepatic steatosis and diabetes mellitus in humans. Bilirubin has antioxidant and anti-inflammatory activities and may also regulate insulin signaling and peroxisome proliferator-activated receptor alpha (PPAR alpha) activity. However, a causal link between bilirubin and metabolic diseases remains to be established. Here, we used the global Bvra gene knockout (Bvra(-/-)) mouse as a model of deficiency in bilirubin to assess its role in metabolic diseases.
   Approach & results: We fed mice fat-rich diets to induce hepatic steatosis and insulin resistance. Bile pigments were measured by LC-MS/MS, and hepatic lipids by LC-MS/MS (non-targeted lipidomics), HPLC-UV and Oil-Red-O staining. Oxidative stress was evaluated measuring F-2-isoprostanes by GC-MS. Glucose metabolism and insulin sensitivity were verified by glucose and insulin tolerance tests, ex vivo and in vivo glucose uptake, and Western blotting for insulin signaling. Compared with wild type littermates, Bvra(-/-) mice contained negligible bilirubin in plasma and liver, and they had comparable glucose metabolism and insulin sensitivity. However, Bvra(-/-) mice exhibited an inflamed and fatty liver phenotype, accompanied by hepatic accumulation of oxidized tri-acylglycerols and F-2-isoprostanes, in association with depletion of alpha-tocopherol. alpha-Tocopherol supplementation reversed the hepatic phenotype and observed biochemical changes in Bvra(-/-) mice.
   Conclusions: Our data suggests that BVRA deficiency renders mice susceptible to oxidative stress-induced hepatic steatosis in the absence of insulin resistance.
C1 [Chen, Weiyu; Tumanov, Sergey; Shaik, Taqi; Suarna, Cacang; Stocker, Roland] Univ Sydney, Heart Res Inst, Sydney, NSW, Australia.
   [Chen, Weiyu; Tumanov, Sergey; Dunn, Louise L.; Suarna, Cacang; Stocker, Roland] Victor Chang Cardiac Res Inst, Sydney, NSW, Australia.
   [Fazarkeley, Daniel; James, David E.] Univ Sydney, Charles Perkins Ctr, Sch Life & Environm Sci, Sydney, NSW, Australia.
   [Fazarkeley, Daniel] Univ Cambridge, Wellcome Med Res Council, Inst Metab Sci, Metab Res Lab, Cambridge, England.
   [Cantley, James] Univ Dundee, Sch Med, Div Syst Med, Dundee, Scotland.
   [Cantley, James] Univ Oxford, Dept Physiol Anat & Genet, Oxford, England.
   [James, David E.; Stocker, Roland] Univ Sydney, Sch Life & Environm Sci, Sydney, NSW, Australia.
C3 University of Sydney; Heart Research Institute; Victor Chang Cardiac
   Research Institute; University of Sydney; University of Cambridge;
   University of Dundee; University of Oxford; University of Sydney
RP Stocker, R (corresponding author), 7 Eliza St, Newtown, NSW 2042, Australia.
EM roland.stocker@hri.org.au
RI Stocker, Roland/AAV-4489-2021; James, David/KYY-9051-2024; Tumanov,
   Sergey/AAP-8003-2021; Chen, Weiyu/ABG-8195-2020; Fazakerley,
   Daniel/J-2652-2019
OI Fazakerley, Daniel/0000-0001-8241-2903; Cantley,
   James/0000-0003-2509-1271; Tumanov, Sergey/0000-0002-0557-3153; James,
   David/0000-0001-5946-5257; Suarna, Cacang/0009-0008-4417-8691
FU National Health & Medical Research Council of Australia [1052616,
   1111632]; University of New South Wales International Postgraduate
   Award; Senior Principal Research Fellowship [1111632]; National Health
   and Medical Research Council of Australia [1111632] Funding Source:
   NHMRC
FX Financial support statement This work was supported by National Health &
   Medical Research Council of Australia Program Grant 1052616 and Senior
   Principal Research Fellowship 1111632 to RS. WC acknowledges support
   received in form of a University of New South Wales International
   Postgraduate Award.
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NR 60
TC 20
Z9 20
U1 0
U2 16
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2213-2317
J9 REDOX BIOL
JI Redox Biol.
PD NOV
PY 2021
VL 47
AR 102152
DI 10.1016/j.redox.2021.102152
EA OCT 2021
PG 13
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA WI5YY
UT WOS:000708436800003
PM 34610553
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Cheng, XL
   Qiu, LW
   Wang, F
AF Cheng Xiaoli
   Qiu Linwei
   Wang Fen
TI 18α-Glycyrrhetinic acid (GA) ameliorates fructose-induced nephropathy in
   mice by suppressing oxidative stress, dyslipidemia and inflammation
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Article
DE Fructose; 18 alpha-Glycyrrhetinic acid (GA); ROS accumulation;
   Dyslipidemia; Inflammatory response
ID INDUCED METABOLIC SYNDROME; NF-KAPPA-B; DIABETIC-NEPHROPATHY;
   LIPID-ACCUMULATION; SIGNALING PATHWAY; ACTIVATION; DAMAGE; KIDNEY;
   INJURY; LIVER
AB Excessive fructose (FRU) intake can result in insulin resistance and metabolic disorder, which are related to renal injury. 18 alpha-Glycyrrhetinic acid (GA) is a bioactive component mainly extracted from Glycyrrhiza radix, and has anti-oxidant and anti-inflammatory activities. However, its effects on FRU-induced renal injury still remain unclear. In this study, we found that 18 alpha-GA treatments could significantly ameliorate the cell viability in FRU-treated tubule epithelial cells, accompanied with improved mitochondrial membrane potential. Furthermore, reactive oxygen species (ROS) accumulation in FRU-stimulated cells was markedly reduced by 18 alpha-GA, which were associated with the activation of nuclear factor (erythroid-derived-2)-like 2 (Nrf-2) and the blockage of MAPKs signaling. Additionally, dyslipidemia detected in FRU-treated cells was greatly inhibited by 18 alpha-GA. We also found that 18 alpha-GA significantly ameliorated FRU-induced inflammation in cells through reducing the expression of pro-inflammatory cytokines and chemokine. The anti-inflammatory effects regulated by 18 alpha-GA were mainly related to the repression of nuclear factor-kappa B(NF-kappa B) signaling. Furthermore, the protective effects of 18 alpha-GA against ROS production, lipid accumulation and inflammation were verified in renal tissues from FRU-challenged mice, consequently improving metabolic disorder and kidney injury. Taken together, these findings demonstrated that 18 alpha-GA exerted renal protective effects through reducing oxidative stress, lipid deposition and inflammatory response, and thus could be considered as a promising therapeutic strategy for metabolic stress-induced kidney injury.
C1 [Cheng Xiaoli] Ankang City Ctr Hosp, Dept Hemodialysis, Ankang 725000, Peoples R China.
   [Qiu Linwei] Shandong Univ, Shandong Prov ENT Hosp, Dept Endocrinol, Jinan 250022, Peoples R China.
   [Wang Fen] Beijing Univ Chinese Med, Affiliated Hosp 3, Dept Endocrinol, Beijing 100029, Peoples R China.
C3 Shandong University; Beijing University of Chinese Medicine
RP Wang, F (corresponding author), Beijing Univ Chinese Med, Affiliated Hosp 3, Dept Endocrinol, Beijing 100029, Peoples R China.
EM tonyshiu1976@qq.com
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NR 63
TC 22
Z9 24
U1 2
U2 24
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD MAY
PY 2020
VL 125
AR 109702
DI 10.1016/j.biopha.2019.109702
PG 14
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA KU2DX
UT WOS:000519520000014
PM 32106383
OA gold
DA 2025-06-11
ER

PT J
AU Tang, TH
   Hwang, JH
   Yang, TH
   Hsu, CJ
   Wu, CC
   Liu, TC
AF Tang, Ting-Hsuan
   Hwang, Juen-Haur
   Yang, Ting-Hua
   Hsu, Chuan-Jen
   Wu, Chen-Chi
   Liu, Tien-Chen
TI Can Nutritional Intervention for Obesity and Comorbidities Slow Down
   Age-Related Hearing Impairment?
SO NUTRIENTS
LA English
DT Article
DE obesity; age-related hearing impairment; nutrition
ID POLYUNSATURATED FATTY-ACIDS; DIABETES-MELLITUS; INNER-EAR; ADIPONECTIN;
   ASSOCIATION; PLASMA; RISK; DYSFUNCTION; INSULIN; HYPERLIPIDEMIA
AB Background: Age-related hearing impairment (ARHI), the most common sensory deficit in the elderly, is associated with enormous social and public health burdens. Emerging evidence has suggested that obesity and comorbidities might increase the risk of ARHI. However, no reviews have been published that address the role of nutritional interventions for obesity and comorbidities in the prevention of ARHI. Methods: A PubMed database search was conducted to identify the relationship between obesity and ARHI. "Obesity", "metabolic syndrome", "adipose-derived hormone", "fatty acid", and "age-related hearing impairment" were included as keywords. Results: A total of 89 articles was analyzed with 39 articles of relevance to ARHI. A high-fat diet may induce oxidative stress, mitochondrial damage, and apoptosis in the inner ear. Statins have been shown to delay the progression of ARHI by improving the lipid profile, reducing oxidative stress, and inhibiting endothelial inflammation. Aldosterone could exert protective effects against ARHI by upregulating the Na-K-2Cl co-transporter 1 in the cochlea. Omega-3 polyunsaturated fatty acids could preserve the cochlear microcirculation by reducing dyslipidemia and inhibiting inflammation. Alpha-lipoic acid and lecithin might delay the progression of ARHI by protecting cochlear mitochondrial DNA from damage due to oxidative stress. Tea and ginseng might protect against ARHI through their anti-obesity and anti-diabetic effects. Conclusions: Nutritional interventions for obesity and comorbidities, including a low-fat diet, supplementation with statins, aldosterone, omega-3 polyunsaturated fatty acids, alpha-lipoic acids, lecithin, tea, and ginseng, may protect against the development of ARHI.
C1 [Tang, Ting-Hsuan; Yang, Ting-Hua; Wu, Chen-Chi; Liu, Tien-Chen] Natl Taiwan Univ Hosp, Dept Otolaryngol, Taipei 100, Taiwan.
   [Hwang, Juen-Haur] Buddhist Tzu Chi Med Fdn, Dalin Tzu Chi Hosp, Dept Otolaryngol Head & Neck Surg, Chiayi 622, Taiwan.
   [Hwang, Juen-Haur; Hsu, Chuan-Jen] Tzu Chi Univ, Sch Med, Hualien 970, Taiwan.
   [Hwang, Juen-Haur] China Med Univ, China Med Univ Hosp, Dept Med Res, Taichung 404, Taiwan.
   [Hsu, Chuan-Jen] Taichung Tzu Chi Hosp, Dept Otolaryngol, Taichung 427, Taiwan.
   [Wu, Chen-Chi; Liu, Tien-Chen] Natl Taiwan Univ, Coll Med, Dept Otolaryngol, Taipei 100, Taiwan.
C3 National Taiwan University; National Taiwan University Hospital;
   Buddhist Tzu Chi General Hospital; Dalin Tzu Chi Hospital; Tzu Chi
   University; China Medical University Taiwan; China Medical University
   Hospital - Taiwan; Buddhist Tzu Chi General Hospital; Taichung Tzu Chi
   Hospital; National Taiwan University
RP Wu, CC; Liu, TC (corresponding author), Natl Taiwan Univ Hosp, Dept Otolaryngol, Taipei 100, Taiwan.; Wu, CC; Liu, TC (corresponding author), Natl Taiwan Univ, Coll Med, Dept Otolaryngol, Taipei 100, Taiwan.
EM chenchiwu@ntuh.gov.tw; liuent@ntu.edu.tw
OI LIU, TIEN-CHEN/0000-0001-6771-5025; WU, CHEN-CHI/0000-0002-5047-2204
FU Ministry of Science and Technology of Taiwan [MOST
   107-2314-B-002-137-MY3]; National Taiwan University Hospital [NTUH
   108-S4425]
FX This research was funded by the Ministry of Science and Technology of
   Taiwan (MOST 107-2314-B-002-137-MY3, to C-C.W.) and National Taiwan
   University Hospital (NTUH 108-S4425, to T-C.L.).
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NR 85
TC 13
Z9 13
U1 2
U2 14
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JUL
PY 2019
VL 11
IS 7
AR 1668
DI 10.3390/nu11071668
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA IN7TT
UT WOS:000478885400176
PM 31330876
OA Green Submitted, gold, Green Published
DA 2025-06-11
ER

PT J
AU Gregersen, N
   Hansen, J
   Palmfeldt, J
AF Gregersen, Niels
   Hansen, Jakob
   Palmfeldt, Johan
TI Mitochondrial proteomics-a tool for the study of metabolic disorders
SO JOURNAL OF INHERITED METABOLIC DISEASE
LA English
DT Article; Proceedings Paper
CT Annual Symposium of the
   Society-for-the-Study-of-Inborn-Errors-of-Metabolism (SSIEM) / Meeting
   of the International-Society-for-Newborn-Screening
CY AUG 30-SEP 02, 2011
CL Geneva, SWITZERLAND
SP Soc Study Inborn Erorrs Metab (SSIEM), Swiss Grp Inborn Errors Metab (SGIEM), Int Soc Newborn Screening
ID FATTY-ACID OXIDATION; DEHYDROGENASE SCAD DEFICIENCY; MASS-SPECTROMETRY;
   CELLULAR STRESS; REDOX PROTEOMICS; PROTEIN; IDENTIFICATION; EXPRESSION;
   PHOSPHORYLATION; DYSFUNCTION
AB Mitochondria are important for a number of life and death processes, such as energy production, creation of reactive oxygen species, and elicitation of stress responses. These responses range from induction of protein quality control and antioxidant systems to mitochondria elimination and cell death. Mitochondrial dysfunctions are involved in pathologies associated with many diseases, for example metabolic disorders, diabetes, cancers, cardiovascular and neurodegenerative diseases as well as obesity and aging. Mitochondrial proteomics can be a powerful tool in the study of these diseases, especially since it can cover mitochondrial proteins from several metabolic pathways, such as the citric acid cycle, fatty acid oxidation, and respiratory chain, as well as protein networks involved in stress responses. The mitochondrial proteome can consist of more than 1,000 different proteins. However, it is difficult to define the precise number, since mitochondria are dynamic and difficult to purify, and because an unknown number of proteins possess dual or multiple localization, depending on cell type and physiological conditions. This review describes several quantitative studies of proteins from mitochondria isolated by centrifugation, separated by various methods (e.g., electrophoresis and nanoLC), and analyzed by advanced mass spectrometry. We illustrate the methods by showing that multiple pathways and networks are affected in cells from patients carrying gene variations affecting a mitochondrial protein. The study of cultured skin fibroblasts from patients with ethylmalonic aciduria associated with variations in the genes coding for short-chain acyl-CoA dehydrogenase (SCAD) or ETHE1 are two of the examples. The possibility of obtaining mitochondrial proteomics data from whole cell proteomics studies is also exemplified by the involvement of liver mitochondria in metabolic syndrome.
C1 [Palmfeldt, Johan] Aarhus Univ Hosp, DK-8200 Aarhus, Denmark.
   [Gregersen, Niels; Hansen, Jakob; Palmfeldt, Johan] Aarhus Univ, Res Unit Mol Med, Inst Clin Med, Fac Hlth Sci, Aarhus, Denmark.
   [Hansen, Jakob] Aarhus Univ, Dept Forens Med, Fac Hlth Sci, Aarhus, Denmark.
C3 Aarhus University; Aarhus University; Aarhus University
RP Palmfeldt, J (corresponding author), Aarhus Univ Hosp, DK-8200 Aarhus, Denmark.
EM johan.palmfeldt@ki.au.dk
RI Hansen, Jakob/W-1318-2017
OI Palmfeldt, Johan/0000-0001-5585-639X
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NR 103
TC 37
Z9 39
U1 1
U2 30
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0141-8955
EI 1573-2665
J9 J INHERIT METAB DIS
JI J. Inherit. Metab. Dis.
PD JUL
PY 2012
VL 35
IS 4
BP 715
EP 726
DI 10.1007/s10545-012-9480-3
PG 12
WC Endocrinology & Metabolism; Genetics & Heredity; Medicine, Research &
   Experimental
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Endocrinology & Metabolism; Genetics & Heredity; Research & Experimental
   Medicine
GA 968DX
UT WOS:000305958300016
PM 22526845
DA 2025-06-11
ER

PT J
AU Beltowski, J
   Wojcicka, G
   Jakubowski, H
AF Beltowski, Jerzy
   Wojcicka, Grazyna
   Jakubowski, Hieronim
TI Modulation of paraoxonase 1 and protein N-homocysteinylation by
   leptin and the synthetic liver X receptor agonist T0901317 in the rat
SO JOURNAL OF ENDOCRINOLOGY
LA English
DT Article
ID SERUM PARAOXONASE; ENDOTHELIAL DYSFUNCTION; THIOLACTONASE ACTIVITY;
   DENSITY-LIPOPROTEINS; OXIDATIVE STRESS; BIOLOGICAL ROLE; PLASMA;
   ATHEROSCLEROSIS; MECHANISM; DISEASE
AB The adipose tissue hormone leptin and homocysteine (Hcy)-thiolactone are linked to the pathogenesis of atherosclerosis through their interactions with the anti-atherogenic enzyme paraoxonase 1 that has the ability to hydrolyze Hcy-thiolactone and minimizes protein N-homocysteinylation. Here we examined the relationships between hyperleptinemia, Hcy-thiolactonase, and protein N-homocysteinylation in rats. Hyperleptinemia was induced in adult rats by administration of leptin for 7 days (0.25 mg/kg twice daily s.c). We found that serum Hcy-thiolactonase was lower in hyperleptinemic than in control animals (-41.0%, P < 0.001). Leptin administration increased the level of N-linked Hcy in plasma proteins (+92.9%, P < 0.01), but had no effect on plasma total Hcy. These effects were not reproduced by pair-feeding. We also found that the synthetic liver X receptor (LXR) agonist, T0901317 (1 mg/kg per day) normalized Hcy-thiolactonase and protein N-homocysteinylation levels in leptin-treated rats. However, leptin-induced increase in plasma isoprostane levels (a marker of oxidative stress) was not normalized by T0901317. The NADPH oxidase inhibitor apocynin prevented leptin-induced increase in isoprostane levels but did not normalize Hcy-thiolactonase and protein N-homocysteinylation levels. These results suggest that the decreased capacity to metabolize Hcy-thiolactone and concomitant increase in protein N-homocysteinylation contribute to pro-atherogenic effect of chronic hyperleptinemia, independently of oxidative stress. LXR agonists normalize Hcy-thiolactonase levels and decrease protein N-homocysteinylation, especially under conditions associated with excess leptin such as metabolic syndrome. Journal of Endocrinology (2010) 204, 191-198
C1 [Beltowski, Jerzy; Wojcicka, Grazyna] Med Univ, Dept Pathophysiol, PL-20090 Lublin, Poland.
   [Jakubowski, Hieronim] Univ Med & Dent New Jersey, Int Ctr Publ Hlth, New Jersey Med Sch, Dept Microbiol & Mol Genet, Newark, NJ 07101 USA.
   [Jakubowski, Hieronim] Univ Life Sci, Dept Biochem & Biotechnol, PL-60637 Poznan, Poland.
C3 Medical University of Lublin; Rutgers University System; Rutgers
   University New Brunswick; Rutgers University Biomedical & Health
   Sciences; Poznan University of Life Sciences
RP Beltowski, J (corresponding author), Med Univ, Dept Pathophysiol, Ul Jaczewskiego 8, PL-20090 Lublin, Poland.
EM jerzy.beltowski@am.lublin.pl
RI Beltowski, Jerzy/AAH-4692-2020; Jakubowski, Hieronim/AAA-6834-2019;
   Jakubowski, Hieronim/A-2510-2017
OI Jakubowski, Hieronim/0000-0001-5845-4409; Wojcicka,
   Grazyna/0000-0002-1822-5027; Beltowski, Jerzy/0000-0001-7903-8121
FU Medical University, Lublin, Poland [DS476]
FX The study was supported by grant #DS476 from Medical University, Lublin,
   Poland.
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NR 56
TC 18
Z9 18
U1 0
U2 7
PU BIOSCIENTIFICA LTD
PI BRISTOL
PA STARLING HOUSE, 1600 BRISTOL PARKWAY N, BRISTOL, ENGLAND
SN 0022-0795
EI 1479-6805
J9 J ENDOCRINOL
JI J. Endocrinol.
PD FEB
PY 2010
VL 204
IS 2
BP 191
EP 198
DI 10.1677/JOE-09-0298
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 568NB
UT WOS:000275528000011
PM 19887391
OA Bronze
DA 2025-06-11
ER

EF﻿FN Clarivate Analytics Web of Science
VR 1.0
PT J
AU Inoguchi, T
   Li, P
   Umeda, F
   Yu, HY
   Kakimoto, M
   Imamura, M
   Aoki, T
   Etoh, T
   Hashimoto, T
   Naruse, M
   Sano, H
   Utsumi, H
   Nawata, H
AF Inoguchi, T
   Li, P
   Umeda, F
   Yu, HY
   Kakimoto, M
   Imamura, M
   Aoki, T
   Etoh, T
   Hashimoto, T
   Naruse, M
   Sano, H
   Utsumi, H
   Nawata, H
TI High glucose level and free fatty acid stimulate reactive oxygen species
   production through protein kinase C-dependent activation of NAD(P)H
   oxidase in cultured vascular cells
SO DIABETES
LA English
DT Article
ID SMOOTH-MUSCLE CELLS; CHRONIC GRANULOMATOUS-DISEASE; RENIN-ANGIOTENSIN
   SYSTEM; ELECTRON-SPIN-RESONANCE; GTP-BINDING PROTEIN; NADPH OXIDASE;
   ENDOTHELIAL-CELLS; SUPEROXIDE PRODUCTION; OXIDATIVE STRESS; DIABETIC
   RATS
AB Recent studies have revealed that vascular cells can produce reactive oxygen species (ROS) through NAD(P)H oxidase, which may be involved in vascular injury. However, the pathological role of vascular NAD(P)H oxidase in diabetes or in the insulin-resistant state remains unknown. In this study, we examined the effect of high glucose level and free fatty acid (FFA) (palmitate) on ROS production in cultured aortic smooth muscle cells (SMCs) and endothelial cells (ECs) using electron spin resonance spectroscopy. Exposure of cultured SMCs or ECs to a high glucose level (400 mg/dl) for 72 h significantly increased the free radical production compared with low glucose level exposure (100 mg/dl), Treatment of the cells for 3 h with phorbol myristic acid (PMA), a protein kinase C (PKC) activator, also increased free radical production. This increase was restored to the control value by diphenylene iodonium, a NAD(P)H oxidase inhibitor, suggesting ROS production through PKC-dependent activation of NAD(P)H oxidase, The increase in free radical production by high glucose level exposure was completely restored by both diphenylene iodonium and GF109203X, a PKC-specific inhibitor. Exposure to palmitate (200 mu mol/l) also increased free radical production, which was concomitant with increases in diacylglycerol. level and PKC activity. Again, this increase was restored to the control value by both diphenylene iodonium and GF109203X. The present results suggest that both high glucose level and palmitate may stimulate ROS production through PKC-dependent activation of NAD(P)H oxidase in both vascular SMCs and ECs. This finding may be involved in the excessive acceleration of atherosclerosis in patients with diabetes and insulin resistance syndrome.
C1 Kyushu Univ, Grad Sch Med Sci, Dept Med & Bioregulatory Sci, Fukuoka 8128582, Japan.
   Kyushu Univ, Grad Sch Pharmaceut Sci, Dept Biophys, Fukuoka 8128582, Japan.
   Daiichi Radioisotope Labs, Tokyo, Japan.
C3 Kyushu University; Kyushu University
RP Kyushu Univ, Grad Sch Med Sci, Dept Med & Bioregulatory Sci, Fukuoka 8128582, Japan.
EM toyoshi@intmed3.med.kyushu-u.ac.jp
OI Inoguchi, Toyoshi/0000-0002-7344-6199
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NR 57
TC 1261
Z9 1453
U1 2
U2 106
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0012-1797
EI 1939-327X
J9 DIABETES
JI Diabetes
PD NOV
PY 2000
VL 49
IS 11
BP 1939
EP 1945
DI 10.2337/diabetes.49.11.1939
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 370LC
UT WOS:000165123700024
PM 11078463
OA Bronze
DA 2025-06-11
ER

PT J
AU Liu, YY
   Xu, W
   Zhai, T
   You, JJ
   Chen, Y
AF Liu, Yayun
   Xu, Wei
   Zhai, Ting
   You, Jiaojiao
   Chen, Yong
TI Silibinin ameliorates hepatic lipid accumulation and oxidative stress in
   mice with non-alcoholic steatohepatitis by regulating CFLAR-JNK pathway
SO ACTA PHARMACEUTICA SINICA B
LA English
DT Article
DE Silibinin; NASH; CFLAR; Lipid accumulation; Oxidation stress
ID FATTY-LIVER-DISEASE; TRIGLYCERIDE TRANSFER PROTEIN; INSULIN-RESISTANCE;
   CYTOCHROME-P450 2E1; STEATOSIS; MODEL; ACID; CYP2E1; INJURY; NAFLD
AB Non-alcoholic steatohepatitis (NASH) is a chronic metabolic syndrome and the CFLAR-JNK pathway can reverse the process of NASH. Although silibinin is used for the treatment of NASH in clinical, its effect on CFLAR-JNK pathway in NASH remains unclear. This study aimed to investigate the effect of silibinin on CFLAR-JNK pathway in NASH models both in vivo and in vitro. The in vivo study was performed using male C57BL/6 mice fed with methionine choline-deficient diet and simultaneously treated with silibinin for 6 weeks. The in vitro study was performed by using mouse NCTC-1469 cells which were respectively pretreated with oleic acid plus palmitic acid, and adenovirus-down Cflar for 24 h, then treated with silibinin for 24 h. After the drug treatment, the key indicators involved in CFLAR-JNK pathway including hepatic injury, lipid metabolism and oxidative stress were determined. Silibinin significantly activated CFLAR and inhibited the phosphorylation of JNK, up-regulated the mRNA expression of Ppara, Fabp5, Cptla, Acox, Scd-1, Gpat and Mttp, reduced the activities of serum ALT and AST and the contents of hepatic TG, TC and MDA, increased the expression of NRF2 and the activities of CAT, GSH-Px and HO-1, and decreased the activities and expression of CYP2E1 and CYP4A in vivo. These effects were confirmed by the in vitro experiments. Silibinin prevented NASH by regulating CFLAR-JNK pathway, and thereby on one hand promoting the beta-oxidation and efflux of fatty acids in liver to relieve lipid accumulation, and on the other hand inducing antioxidase activity (CAT, GSH-Px and HO-1) and inhibiting pro-oxidase activity (CYP2E1 and CYP4A) to relieve oxidative stress. (C) 2019 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.
C1 [Liu, Yayun; Xu, Wei; Zhai, Ting; You, Jiaojiao; Chen, Yong] Hubei Univ, Natl & Local Joint Engn Res Ctr High Throughput D, Hubei Prov Key Lab Biotechnol Chinese Tradit Med, Wuhan 430062, Hubei, Peoples R China.
C3 Hubei University
RP Chen, Y (corresponding author), Hubei Univ, Natl & Local Joint Engn Res Ctr High Throughput D, Hubei Prov Key Lab Biotechnol Chinese Tradit Med, Wuhan 430062, Hubei, Peoples R China.
EM cy101610@hubu.edu.cn
FU Major Technological Innovation Project of Hubei Province (China)
   [2016ACA140]; Innovation and Entrepreneurship Training Project for
   College Students of the Ministry of Education (China) [201610512001]
FX This work was supported by Major Technological Innovation Project of
   Hubei Province (Grant no. 2016ACA140, China) and Innovation and
   Entrepreneurship Training Project for College Students of the Ministry
   of Education (Grant no. 201610512001, China).
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NR 55
TC 123
Z9 131
U1 0
U2 53
PU INST MATERIA MEDICA, CHINESE ACAD MEDICAL SCIENCES
PI BEIJING
PA C/O EDITORIAL BOARD OF ACTA PHARMACEUTICA SINICA, 1 XIANNONGTAN ST,
   BEIJING, 100050, PEOPLES R CHINA
SN 2211-3835
EI 2211-3843
J9 ACTA PHARM SIN B
JI Acta Pharm. Sin. B
PD JUL
PY 2019
VL 9
IS 4
BP 745
EP 757
DI 10.1016/j.apsb.2019.02.006
PG 13
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA IK6WT
UT WOS:000476730700008
PM 31384535
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Schneider, D
   Hernández, C
   Farias, M
   Uauy, R
   Krause, BJ
   Casanello, P
AF Schneider, D.
   Hernandez, C.
   Farias, M.
   Uauy, R.
   Krause, B. J.
   Casanello, P.
TI Oxidative stress as common trait of endothelial dysfunction in chorionic
   arteries from fetuses with IUGR and LGA
SO PLACENTA
LA English
DT Article
DE Endothelial function; IUGR; LGA; Maternal obesity; Oxidative stress
ID MATERNAL OBESITY; BIRTH-WEIGHT; NITRIC-OXIDE; NADPH OXIDASE; VASCULAR
   REACTIVITY; METABOLIC SYNDROME; GENE-EXPRESSION; OVERWEIGHT;
   CONTRIBUTES; ACTIVATION
AB Introduction: Fetal macrosomia and intrauterine growth restriction (IUGR) associate with increased morbidity in the neonate. Placental vascular relaxation is impaired in fetal macrosomia, as well as in IUGR, and this could result from increased oxidative stress present in both conditions. We determined the role of pro- and anti-oxidants on NOS dependent relaxation in placental chorionic arteries from pregnancies with LGA babies from overweight and/or obese mothers (LOOM) and IUGR fetuses from normal BMI women.
   Methods: Chorionic arteries were mounted in a wire-myograph, where responses to the NOS-dependent agent CGRP in presence or absence of the antioxidant N-acetyl cysteine (NAC), the pro-oxidant SIN-1, the SOD inhibitor DDC, and the GPx inhibitor MS were determined. Additionally the presence of pro- and antioxidant enzymes (NOX-4, SOD-1, SOD-2 and GPx-1) and eNOS in chorionic and umbilical vessels were addressed by immunohistochemistry.
   Results: Maximal CGRP-induced relaxation was comparable to controls but presented a reduced potency in chorionic arteries from LOOM placentae, whilst in IUGR vessels both maximal response and potency were reduced. NAC increased maximal relaxation in controls, IUGR and LOOM arteries, whilst SIN-1 completely abolished the CGRP-induced relaxation only in IUGR and LOOM samples, the later effect was paralleled by SOD or GPx inhibition. These responses associated with the presence of NOX-4, SOD-1 and GPx-1 in the endothelium and vascular wall of chorionic and umbilical arteries in the different groups studied.
   Discussion: These data suggest that NOS dependent relaxation in placental vessels from IUGR and LOOM pregnancies present a higher sensitivity to oxidative stress. (C) 2015 Elsevier Ltd. All rights reserved.
C1 [Schneider, D.; Hernandez, C.; Farias, M.; Krause, B. J.; Casanello, P.] Pontificia Univ Catolica Chile, Div Obstet & Gynecol, Fac Med, Santiago, Chile.
   [Hernandez, C.; Uauy, R.; Casanello, P.] Pontificia Univ Catolica Chile, Fac Med, Div Pediat, Santiago, Chile.
C3 Pontificia Universidad Catolica de Chile; Pontificia Universidad
   Catolica de Chile
RP Casanello, P (corresponding author), Pontificia Univ Catolica Chile, Div Obstet & Gynecol, Sch Med, Marcoleta 391, Santiago, Chile.
EM pcasane@uc.cl
RI Farias, Marcelo/R-6063-2019; Casanello, Paola/X-7443-2019; Krause,
   Bernardo/F-4977-2013; farias jofre, marcelo/C-5260-2011
OI Krause, Bernardo/0000-0002-3563-6143; farias jofre,
   marcelo/0000-0003-0473-2295; Casanello, Paola/0000-0002-2355-1476
FU FONDECYT [1120928, 1130801]
FX This work was funded by FONDECYT 1120928 & 1130801.
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NR 39
TC 41
Z9 45
U1 0
U2 13
PU W B SAUNDERS CO LTD
PI LONDON
PA 32 JAMESTOWN RD, LONDON NW1 7BY, ENGLAND
SN 0143-4004
EI 1532-3102
J9 PLACENTA
JI Placenta
PD MAY
PY 2015
VL 36
IS 5
BP 552
EP 558
DI 10.1016/j.placenta.2015.02.003
PG 7
WC Developmental Biology; Obstetrics & Gynecology; Reproductive Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Developmental Biology; Obstetrics & Gynecology; Reproductive Biology
GA CG9CL
UT WOS:000353611900005
PM 25747728
DA 2025-06-11
ER

PT J
AU Bass, V
   Gordon, CJ
   Jarema, KA
   MacPhail, RC
   Cascio, WE
   Phillips, PM
   Ledbetter, AD
   Schladweiler, MC
   Andrews, D
   Miller, D
   Doerfler, DL
   Kodavanti, UP
AF Bass, V.
   Gordon, C. J.
   Jarema, K. A.
   MacPhail, R. C.
   Cascio, W. E.
   Phillips, P. M.
   Ledbetter, A. D.
   Schladweiler, M. C.
   Andrews, D.
   Miller, D.
   Doerfler, D. L.
   Kodavanti, U. P.
TI Ozone induces glucose intolerance and systemic metabolic effects in
   young and aged brown Norway rats
SO TOXICOLOGY AND APPLIED PHARMACOLOGY
LA English
DT Article
DE Aging; Air pollution; Ozone; Metabolic syndrome; Serum biomarkers;
   Epinephrine
ID ENDOPLASMIC-RETICULUM STRESS; LONG-TERM EXPOSURE; AIR-POLLUTION;
   INSULIN-RESISTANCE; PARTICULATE MATTER; INFLAMMATORY MARKERS; OBESITY;
   LEPTIN; FISCHER-344; PARAMETERS
AB Air pollutants have been associated with increased diabetes in humans. We hypothesized that ozone would impair glucose homeostasis by altering insulin signaling and/or endoplasmic reticular (ER) stress in young and aged rats. One, 4, 12, and 24 month old Brown Norway (BN) rats were exposed to air or ozone, 0.25 or 1.0 ppm, 6 h/day for 2 days (acute) or 2 d/week for 13 weeks (subchronic). Additionally, 4month old rats were exposed to air or 1.0 ppm ozone, 6 h/day for 1 or 2 days (time-course). Glucose tolerance tests (GTT) were performed immediately after exposure. Serum and tissue biomarkers were analyzed 18 h after final ozone for acute and subchronic studies, and immediately after each day of exposure in the time-course study. Age-related glucose intolerance and increases in metabolic biomarkers were apparent at baseline. Acute ozone caused hyperglycemia and glucose intolerance in rats of all ages. Ozone-induced glucose intolerance was reduced in rats exposed for 13 weeks. Acute, but not subchronic ozone increased alpha(2)-macroglobulin, adiponectin and osteopontin. Time-course analysis indicated glucose intolerance at days 1 and 2 (2N1), and a recovery 18 h post ozone. Leptin increased day 1 and epinephrine at all times after ozone. Ozone tended to decrease phosphorylated insulin receptor substrate-1 in liver and adipose tissues. ER stress appeared to be the consequence of ozone induced acute metabolic impairment since transcriptional markers of ER stress increased only after 2 days of ozone. In conclusion, acute ozone exposure induces marked systemic metabolic impairments in BN rats of all ages, likely through sympathetic stimulation. Published by Elsevier Inc.
C1 [Bass, V.; Cascio, W. E.; Ledbetter, A. D.; Schladweiler, M. C.; Kodavanti, U. P.] US EPA, Natl Hlth & Environm Effects Res Lab, Environm Publ Hlth Div, Res Triangle Pk, NC 27711 USA.
   [Gordon, C. J.; Jarema, K. A.; MacPhail, R. C.; Phillips, P. M.] US EPA, Natl Hlth & Environm Effects Res Lab, Tox Assessment Div, Res Triangle Pk, NC 27711 USA.
   [Andrews, D.; Doerfler, D. L.] US EPA, Natl Hlth & Environm Effects Res Lab, Res Cores Unit, Res Triangle Pk, NC 27711 USA.
   [Miller, D.] Univ N Carolina, Curriculum Toxicol, Chapel Hill, NC USA.
C3 United States Environmental Protection Agency; United States
   Environmental Protection Agency; United States Environmental Protection
   Agency; University of North Carolina; University of North Carolina
   Chapel Hill
RP Kodavanti, UP (corresponding author), US EPA, NHEERL, MD 8105-02, Res Triangle Pk, NC 27711 USA.
EM kodavanti.urmila@epa.gov
RI Gordon, Christopher/KVB-4813-2024; Cascio, Wayne/GPG-0840-2022
OI Jarema, Kimberly/0000-0002-3418-9679; Bass, Virginia/0000-0001-6219-2448
FU NIEHS NIH HHS [T32 ES007126] Funding Source: Medline
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NR 38
TC 98
Z9 105
U1 5
U2 27
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0041-008X
EI 1096-0333
J9 TOXICOL APPL PHARM
JI Toxicol. Appl. Pharmacol.
PD DEC 15
PY 2013
VL 273
IS 3
BP 551
EP 560
DI 10.1016/j.taap.2013.09.029
PG 10
WC Pharmacology & Pharmacy; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Toxicology
GA 275XC
UT WOS:000328711700015
PM 24103449
OA Green Accepted, Green Submitted
DA 2025-06-11
ER

PT J
AU Antoni, MH
AF Antoni, Michael H.
TI Psychosocial intervention effects on adaptation, disease course and
   biobehavioral processes in cancer
SO BRAIN BEHAVIOR AND IMMUNITY
LA English
DT Review
DE Psychosocial intervention; Stress management; Survival; Recurrence;
   Cancer; Biobehavioral processes
ID QUALITY-OF-LIFE; STRUCTURED PSYCHIATRIC INTERVENTION; STRESS-MANAGEMENT
   INTERVENTION; METASTATIC BREAST-CANCER; EXPRESSIVE GROUP-THERAPY;
   LONG-TERM SURVIVORS; PSYCHOLOGICAL INTERVENTION; METABOLIC SYNDROME;
   CERVICAL-CANCER; IMMUNE FUNCTION
AB A diagnosis of cancer and subsequent treatments place demands on psychological adaptation. Behavioral research suggests the importance of cognitive, behavioral, and social factors in facilitating adaptation during active treatment and throughout cancer survivorship, which forms the rationale for the use of many psychosocial interventions in cancer patients. This cancer experience may also affect physiological adaptation systems (e.g., neuroendocrine) in parallel with psychological adaptation changes (negative affect). Changes in adaptation may alter tumor growth-promoting processes (increased angiogenesis, migration and invasion, and inflammation) and tumor defense processes (decreased cellular immunity) relevant for cancer progression and the quality of life of cancer patients. Some evidence suggests that psychosocial intervention can improve psychological and physiological adaptation indicators in cancer patients. However, less is known about whether these interventions can influence tumor activity and tumor growth-promoting processes and whether changes in these processes could explain the psychosocial intervention effects on recurrence and survival documented to date. Documenting that psychosocial interventions can modulate molecular activities (e.g., transcriptional indicators of cell signaling) that govern tumor promoting and tumor defense processes on the one hand, and clinical disease course on the other is a key challenge for biobehavioral oncology research. This mini-review will summarize current knowledge on psychological and physiological adaptation processes affected throughout the stress of the cancer experience, and the effects of psychosocial interventions on psychological adaptation, cancer disease progression, and changes in stress-related biobehavioral processes that may mediate intervention effects on clinical cancer outcomes. Very recent intervention work in breast cancer will be used to illuminate emerging trends in molecular probes of interest in the hope of highlighting future paths that could move the field of biobehavioral oncology intervention research forward. (C) 2012 Elsevier Inc. All rights reserved.
C1 [Antoni, Michael H.] Univ Miami, Dept Psychol, Coral Gables, FL 33124 USA.
C3 University of Miami
RP Antoni, MH (corresponding author), Univ Miami, Miller Sch Med, Biobehav Oncol Program, Sylvester Canc Ctr, Miami, FL 33136 USA.
EM mantoni@miami.edu
OI Antoni, Michael/0000-0002-3971-0873
FU NCI NIH HHS [R01 CA064710] Funding Source: Medline
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NR 93
TC 113
Z9 134
U1 2
U2 73
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0889-1591
EI 1090-2139
J9 BRAIN BEHAV IMMUN
JI Brain Behav. Immun.
PD MAR 15
PY 2013
VL 30
SI SI
BP S88
EP S98
DI 10.1016/j.bbi.2012.05.009
PG 11
WC Immunology; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Immunology; Neurosciences & Neurology; Psychiatry
GA 111GW
UT WOS:000316510800011
PM 22627072
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Naik, RA
   Mir, MN
   Malik, IA
   Bhardwaj, R
   Alshabrmi, FM
   Mahmoud, MA
   Alhomrani, M
   Alamri, AS
   Alsanie, WF
   Hjazi, A
   Ghatak, T
   Poeggeler, B
   Singh, MP
   Gopenath, TS
   Singh, SK
AF Naik, Rayees Ahmad
   Mir, Mehak Naseer
   Malik, Ishfaq Ahmad
   Bhardwaj, Rima
   Alshabrmi, Fahad M.
   Mahmoud, Mahmoud Abdulrahman
   Alhomrani, Majid
   Alamri, Abdulhakeem S.
   Alsanie, Walaa F.
   Hjazi, Ahmed
   Ghatak, Tanmoy
   Poeggeler, Burkhard
   Singh, Mahendra P.
   Gopenath, T. S. A.
   Singh, Sandeep Kumar
TI The Potential Mechanism and the Role of Antioxidants in Mitigating
   Oxidative Stress in Alzheimer's Disease
SO FRONTIERS IN BIOSCIENCE-LANDMARK
LA English
DT Review
DE Alzheimer's disease; amyloid-beta; amyloid plaques; reactive oxygen
   species; antioxidants; tau protein
ID AMYLOID-BETA; ACID; DYSFUNCTION; TAU; NEURODEGENERATION; ABNORMALITIES;
   RIVASTIGMINE; HYPOTHESIS; DEPOSITION; MANAGEMENT
AB Alzheimer's disease (AD) is the most prevalent cause of dementia and a significant contributor to health issues and mortality among older individuals. This condition involves a progressive deterioration in cognitive function and the onset of dementia. Recent advancements suggest that the development of AD is more intricate than its underlying brain abnormalities alone. In addition, Alzheimer's disease, metabolic syndrome, and oxidative stress are all intricately linked to one another. Increased concentrations of circulating lipids and disturbances in glucose homeostasis contribute to the intensification of lipid oxidation, leading to a gradual depletion of the body's antioxidant defenses. This heightened oxidative metabolism adversely impacts cell integrity, resulting in neuronal damage. Pathways commonly acknowledged as contributors to AD pathogenesis include alterations in synaptic plasticity, disorganization of neurons, and cell death. Abnormal metabolism of some membrane proteins is thought to cause the creation of amyloid (A beta) oligomers, which are extremely hazardous to neurotransmission pathways, especially those involving acetylcholine. The interaction between A beta oligomers and these neurotransmitter systems is thought to induce cellular dysfunction, an imbalance in neurotransmitter signaling, and, ultimately, the manifestation of neurological symptoms. Antioxidants have a significant impact on human health since they may improve the aging process by combating free radicals. Neurodegenerative diseases are currently incurable; however, they may be effectively managed. An appealing alternative is the utilization of natural antioxidants, such as polyphenols, through diet or dietary supplements, which offer numerous advantages. Within this framework, we have extensively examined the importance of oxidative stress in the advancement of Alzheimer's disease, as well as the potential influence of antioxidants in mitigating its effects.
C1 [Naik, Rayees Ahmad] Dr Harisingh Gour Vishwavidyalaya Sagar, Dept Zool, Sagar 470003, Madhya Pradesh, India.
   [Mir, Mehak Naseer] Natl Inst Med Sci NIMS, NIMS Inst Allied Med Sci, Jaipur 303121, Rajasthan, India.
   [Malik, Ishfaq Ahmad] Smt Indiraji Kapadia Commerce & Nya Krishnarao Des, Dept Zool, Bar Ramrao Deshmukh Arts, Amravati 444701, Maharashtra, India.
   [Bhardwaj, Rima] Savitribai Phule Pune Univ, Poona Coll, Dept Chem, Pune 411007, Maharashtra, India.
   [Alshabrmi, Fahad M.] Qassim Univ, Coll Appl Med Sci, Dept Med Labs, Buraydah 51452, Saudi Arabia.
   [Mahmoud, Mahmoud Abdulrahman] Imam Muhammad Ibn Saud Islamic Univ, Coll Med, Dept Family & Community Med, Riyadh 13313, Saudi Arabia.
   [Alhomrani, Majid; Alamri, Abdulhakeem S.; Alsanie, Walaa F.] Taif Univ, Fac Appl Med Sci, Dept Clin Lab Sci, Taif 21944, Saudi Arabia.
   [Alhomrani, Majid; Alamri, Abdulhakeem S.; Alsanie, Walaa F.] Taif Univ, Ctr Biomed Sci Res CBSR, Deanship Sci Res, Taif 21944, Saudi Arabia.
   [Hjazi, Ahmed] Prince Sattam Bin Abdulaziz Univ, Coll Appl Med Sci, Dept Med Lab Sci, Al Kharj 11942, Saudi Arabia.
   [Ghatak, Tanmoy] Sanjay Gandhi Post Grad Inst Med Sci, Dept Emergency Med, Raibareilly Rd, Lucknow 226014, Uttar Pradesh, India.
   [Poeggeler, Burkhard] Georg August Univ Gottingen, Johann Friedrich Blumenbach Inst Zool & Anthropol, Dept Physiol, Fac Biol, Gottingen & Goettingen Research Campus, D-38524 Sassenburg, Germany.
   [Singh, Mahendra P.] Deen Dayal Upadhyaya Gorakhpur Univ, Dept Zool, Gorakhpur 273009, Uttar Pradesh, India.
   JSS Acad Higher Educ & Res, Dept Biotechnol & Bioinformat, Mysuru 570015, Karnataka, India.
   [Singh, Sandeep Kumar] Indian Sci Educ & Technol Fdn, Lucknow 226001, Uttar Pradesh, India.
C3 Dr. Hari Singh Gour University; Savitribai Phule Pune University; Poona
   College of Arts, Science & Commerce; Qassim University; Imam Mohammad
   Ibn Saud Islamic University (IMSIU); Taif University; Taif University;
   Prince Sattam Bin Abdulaziz University; Sanjay Gandhi Postgraduate
   Institute of Medical Sciences; Deen Dayal Upadhyaya Gorakhpur
   University; JSS Academy of Higher Education & Research
RP Singh, MP (corresponding author), Deen Dayal Upadhyaya Gorakhpur Univ, Dept Zool, Gorakhpur 273009, Uttar Pradesh, India.; Singh, SK (corresponding author), Indian Sci Educ & Technol Fdn, Lucknow 226001, Uttar Pradesh, India.
EM mprataps01@gmail.com; sandeeps.bhu@gmail.com
RI Singh, Dr. Sandeep/D-6544-2013; Malik, Ishfaq/R-5453-2019; Alhomrani,
   Majid/HJB-1187-2022; NAIK, RAYEES/O-4097-2016; Alsanie,
   Walaa/ABF-5059-2021; Hjazi, Ahmed/HLH-4596-2023
OI Hjazi, Ahmed/0000-0002-1129-6930; Naik, Rayees Ahmad/0000-0002-7667-6715
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NR 184
TC 2
Z9 2
U1 2
U2 2
PU IMR PRESS
PI ROBINSON
PA 112 ROBINSON RD, ROBINSON, SINGAPORE
SN 2768-6701
EI 2768-6698
J9 FRONT BIOSCI-LANDMRK
JI Front. Biosci.
PD FEB 18
PY 2025
VL 30
IS 2
AR 25551
DI 10.31083/FBL25551
PG 25
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA 2WE7R
UT WOS:001492775400003
PM 40018917
OA gold
DA 2025-06-11
ER

PT J
AU Hori, H
   Kim, Y
AF Hori, Hiroaki
   Kim, Yoshiharu
TI Inflammation and post-traumatic stress disorder
SO PSYCHIATRY AND CLINICAL NEUROSCIENCES
LA English
DT Review
DE cytokine; inflammation; neuroinflammation; post-traumatic stress
   disorder; treatment
ID C-REACTIVE PROTEIN; COMBAT-RELATED PTSD; CEREBROSPINAL-FLUID; TRAUMATIC
   EVENTS; TNF-ALPHA; INTERLEUKIN-6 LEVELS; CYTOKINE ALTERATIONS; COGNITIVE
   FUNCTION; AMYGDALA ACTIVITY; PHYSICAL-ACTIVITY
AB While post-traumatic stress disorder (PTSD) is currently diagnosed based solely on classic psychological and behavioral symptoms, a growing body of evidence has highlighted a link between this disorder and alterations in the immune and inflammatory systems. Epidemiological studies have demonstrated that PTSD is associated with significantly increased rates of physical comorbidities in which immune dysregulation is involved, such as metabolic syndrome, atherosclerotic cardiovascular disease, and autoimmune diseases. In line with this, a number of blood biomarker studies have reported that compared to healthy controls, individuals with PTSD exhibit significantly elevated levels of proinflammatory markers, such as interleukin-1 beta, interleukin-6, tumor necrosis factor-alpha, and C-reactive protein. Moreover, various lines of animal and human research have suggested that inflammation is not only associated with PTSD but also can play an important role in its pathogenesis and pathophysiology. In this review, we first summarize evidence suggestive of increased inflammation in PTSD. We then examine findings that suggest possible mechanisms of inflammation in this disorder in terms of two different but interrelated perspectives: putative causes of increased proinflammatory activities and potential consequences that inflammation generates. Given that there is currently a dearth of treatment options for PTSD, possibilities of new therapeutic approaches using pharmacological and non-pharmacological treatments/interventions that have anti-inflammatory effects are also discussed. Despite the increasing attention given to the inflammatory pathology of PTSD, there remains much to be elucidated, including more detailed mechanisms of inflammation, potential usefulness of inflammatory biomarkers as diagnostic and prognostic markers, and efficacy of novel treatment strategies targeting inflammation.
C1 [Hori, Hiroaki; Kim, Yoshiharu] Natl Ctr Neurol & Psychiat, Natl Inst Mental Hlth, Dept Behav Med, Tokyo, Japan.
C3 National Center for Neurology & Psychiatry - Japan
RP Hori, H (corresponding author), Natl Ctr Neurol & Psychiat, Natl Inst Mental Hlth, Dept Behav Med, Tokyo, Japan.
EM hori@ncnp.go.jp
RI Hori, Hiroaki/AFL-5633-2022
OI Hori, Hiroaki/0000-0002-4548-7110
FU Health Labour Sciences Research Grant from the Japanese Ministry of
   Health, Labour and Welfare [201616028A]; JSPS KAKENHI [16KT0198]; Takeda
   Science Foundation; Japan Research Foundation for Clinical Pharmacology;
   Grants-in-Aid for Scientific Research [16KT0198] Funding Source: KAKEN
FX This study was supported in part by Health Labour Sciences Research
   Grant from the Japanese Ministry of Health, Labour and Welfare
   (201616028A), JSPS KAKENHI (16KT0198), and grants from the Takeda
   Science Foundation and the Japan Research Foundation for Clinical
   Pharmacology.
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NR 162
TC 235
Z9 263
U1 6
U2 62
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1323-1316
EI 1440-1819
J9 PSYCHIAT CLIN NEUROS
JI Psychiatry Clin. Neurosci.
PD APR
PY 2019
VL 73
IS 4
BP 143
EP 153
DI 10.1111/pcn.12820
PG 11
WC Clinical Neurology; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA HT0UD
UT WOS:000464279200001
PM 30653780
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Chung, APYS
   Gurtu, S
   Chakravarthi, S
   Moorthy, M
   Palanisamy, UD
AF Chung, Alexis Panny Y. S.
   Gurtu, Sunil
   Chakravarthi, Srikumar
   Moorthy, Mohanambal
   Palanisamy, Uma D.
TI Geraniin Protects High-Fat Diet-Induced Oxidative Stress in Sprague
   Dawley Rats
SO FRONTIERS IN NUTRITION
LA English
DT Article
DE geraniin; high-fat diet; oxidative stress; type-2 diabetes; rats
ID INSULIN-RESISTANCE; CHRONIC EXPOSURE; BETA-CELLS; OBESITY;
   STEATOHEPATITIS; LIVER; METABOLISM; MECHANISMS; CORILAGIN; PANCREAS
AB Geraniin, a hydrolysable polyphenol derived from Nephelium lappaceum L. fruit rind, has been shown to possess significant antioxidant activity in vitro and recently been recognized for its therapeutic potential in metabolic syndrome. This study investigated its antioxidative strength and protective effects on organs in high-fat diet (HFD)-induced rodents. Rats were fed HFD for 6 weeks to induce obesity, followed by 10 and 50 mg/kg of geraniin supplementation for 4 weeks to assess its protective potential. The control groups were maintained on standard rat chows and HFD for the same period. At the 10th week, oxidative status was assessed and the pancreas, liver, heart and aorta, kidney, and brain of the Sprague Dawley rats were harvested and subjected to pathological studies. HFD rats demonstrated changes in redox balance; increased protein carbonyl content, decreased levels of superoxide dismutase, glutathione peroxidase, and glutathione reductase with a reduction in the non-enzymatic antioxidant mechanisms and total antioxidant capacity, indicating a higher oxidative stress (OS) index. In addition, HFD rats demonstrated significant diet-induced changes particularly in the pancreas. Four-week oral geraniin supplementation, restored the OS observed in the HFD rats. It was able to restore OS biomarkers, serum antioxidants, and the glutathione redox balance (reduced glutathione/oxidized glutathione ratio) to levels comparable with that of the control group, particularly at dosage of 50 mg geraniin. Geraniin was not toxic to the HFD rats but exhibited protection against glucotoxicity and lipotoxicity particularly in the pancreas of the obese rodents. It is suggested that geraniin has the pharmaceutical potential to be developed as a supplement to primary drugs in the treatment of obesity and its pathophysiological sequels.
C1 [Chung, Alexis Panny Y. S.; Gurtu, Sunil; Moorthy, Mohanambal; Palanisamy, Uma D.] Monash Univ Malaysia, Sch Med & Hlth Sci, Sunway City, Malaysia.
   [Chakravarthi, Srikumar] Perdana Univ, Dept Pathol, Serdang, Malaysia.
C3 Monash University; Monash University Malaysia; Perdana University
RP Palanisamy, UD (corresponding author), Monash Univ Malaysia, Sch Med & Hlth Sci, Sunway City, Malaysia.
EM umadevi.palanisamy@monash.edu
RI Moorthy, Mohanambal/GLR-1016-2022; Palanisamy, Uma/I-4700-2014;
   Chakravarthi, Srikumar/AHB-7872-2022
OI Chakravarthi, Srikumar/0000-0002-9888-3301; Chung, Yin-Sir, Alexis
   Panny/0000-0002-4873-5706; Moorthy, Mohanambal/0000-0001-5694-9096
FU Ministry of Higher Education [FRGS/1/2017/SKK08/MUSM/02/2]
FX The authors would like to thank the Ministry of Higher Education,
   FRGS/1/2017/SKK08/MUSM/02/2, for their financial support towards this
   study.
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NR 59
TC 55
Z9 60
U1 1
U2 17
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD MAR 16
PY 2018
VL 5
AR 17
DI 10.3389/fnut.2018.00017
PG 14
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA GB9FT
UT WOS:000429380200001
PM 29616223
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Víquez, MJR
   García-Sánchez, JR
   González, MAT
   López, LG
   Ceballos-Reyes, GM
   Olivares-Corichi, IM
AF Rincon Viquez, M. J.
   Garcia-Sanchez, J. R.
   Tapia Gonzalez, M. A.
   Gutierrez Lopez, L.
   Ceballos-Reyes, G. M.
   Olivares-Corichi, I. M.
TI Insulin Polymers in the Plasma of Obese Subjects Are Associated with
   Elevated Levels of Carbonyl Groups and Are Decreased by (-)-Epicatechin
SO HORMONE AND METABOLIC RESEARCH
LA English
DT Article
DE oxidative damage; insulin resistance; body mass index
ID OXIDATIVE STRESS; METABOLIC SYNDROME; PROTEIN CARBONYL; ADIPOSE-TISSUE;
   RESISTANCE; RISK; DAMAGE; ASSAY; METHYLGLYOXAL; RECEPTORS
AB We investigated whether oxidative damage and insulin polymerization at a systemic level are associated with the insulin resistance (IR) observed in obese subjects. We evaluated 3 groups (n = 16/each) divided according to body mass index (BMI): Normal weight (NW) with a BMI of 18.5-24.9, obese 1 (O1) 30-34.9, and obese 3 (O3) > 40 kg/m(2). IR and oxidative damage status of the groups were established by HOMA value and the analysis of biomarkers of oxidative stress in plasma. Insulin polymers in systemic circulation were detected using an anti-body specific coupled to magnetic beads, which were incubated in plasma from the study groups. Analysis of magnetic beads by electrophoresis on polyacrylamide gel and silver stain assessed the presence of insulin polymers. The inhibition of polymers formation was studied by the presence of (-)-epicatechin. We demonstrated that O1 and O3 subjects with IR showed higher oxidative damage to their plasma lipids and proteins than NW subjects. This oxidative damage was associated with the presence of insulin polymers in the plasma of the O1 and O3 subjects. This polymer showed a high concentration of carbonyl groups by Western blot, suggesting the participation of oxidative damage in the generation of the polymer. The antioxidant (-)-epicatechin decreased the formation of the insulin polymer, indicating that the prevention of oxidative damage can inhibit insulin polymerization. Our study revealed an association between the presence of carbonyl stress, IR, and insulin polymer formation in obese subjects. This study also demonstrates that the antioxidant (-)-epicatechin inhibits insulin polymerization.
C1 [Rincon Viquez, M. J.; Garcia-Sanchez, J. R.; Gutierrez Lopez, L.; Ceballos-Reyes, G. M.; Olivares-Corichi, I. M.] Inst Politecn Nacl, Escuela Super Med, Secc Estudios Posgrad & Invest, Mexico City 11340, DF, Mexico.
   [Tapia Gonzalez, M. A.] Hosp Especialidades Ctr Med La Raza, Ctr Med Nacl La Raza, Dept Endocrinol, Inst Mexicano Seguro Social,Unidad Med Alta Espec, Mexico City, DF, Mexico.
C3 Instituto Politecnico Nacional - Mexico; Instituto Mexicano del Seguro
   Social
RP Olivares-Corichi, IM (corresponding author), Inst Politecn Nacl, Escuela Super Med, Secc Estudios Posgrad & Invest, Plan San Luis & Diaz Miron S-N, Mexico City 11340, DF, Mexico.
EM iolivares@ipn.mx
RI López, Lucía/JCP-2406-2023; Ceballos, Guillermo/A-7507-2013
OI Ceballos, Guillermo/0000-0003-2155-3934; GUTIERREZ LOPEZ,
   LILIANA/0009-0006-5678-7545; Garcia-Sanchez, Jose/0000-0003-4381-8243;
   Olivares Corichi, Ivonne Maria/0000-0002-5608-048X
FU CONACyT [CB-2010-01-157739, CB-20009-01-129889];  [IPN-ESM-SIP
   20130675];  [20130753]
FX This work was supported by the grant IPN-ESM-SIP 20130675, 20130753,
   CONACyT CB-2010-01-157739, and CONACyT CB-20009-01-129889.
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U1 0
U2 3
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0018-5043
EI 1439-4286
J9 HORM METAB RES
JI Horm. Metab. Res.
PD JUN
PY 2014
VL 46
IS 7
BP 499
EP 504
DI 10.1055/s-0034-1371855
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA AI8NA
UT WOS:000337172800008
PM 24810472
DA 2025-06-11
ER

PT J
AU Dong, F
   Ren, J
AF Dong, Feng
   Ren, Jun
TI Adiponectin Improves Cardiomyocyte Contractile Function in
   db/db Diabetic Obese Mice
SO OBESITY
LA English
DT Article
ID ENDOPLASMIC-RETICULUM STRESS; JUN NH2-TERMINAL KINASE; INSULIN-RECEPTOR
   SUBSTRATE-1; ADIPOSE-SPECIFIC PROTEIN; VENTRICULAR MYOCYTES; METABOLIC
   SYNDROME; HEART; DISEASE; PHOSPHORYLATION; ACTIVATION
AB Low levels of adiponectin, a fat-derived hormone, are found to be correlated with coronary heart disease, type 2 diabetes, obesity, and insulin resistance. Conversely, high adiponectin levels are predictive of reduced coronary risk in long-term epidemiologic studies. However, the precise role of adiponectin in cardiomyocyte function is still not clear. This study was designed to examine the role of adiponectin in cardiac contractile function in the db/db model of diabetic obesity. Mechanical properties and intracellular Ca2+ transients were evaluated in cardiomyocytes from lean control and db/db mice with or without adiponectin (10 mu g/ml) treatment. Expression and phosphorylation of IRS-1, Akt, c-Jun, and c-Jun N terminal kinase (JNK) as well as markers of endoplasmic reticulum (ER) stress were evaluated using western blotting. Cardiomyocytes from db/db mice exhibited greater cross-sectional area, depressed peak shortening (PS), and maximal velocity of shortening/re-lengthening as well as prolonged duration of re-lengthening. Consistently, myocytes from db/db mice displayed a reduced electrically stimulated rise in intracellular Ca2+ and prolonged intracellular Ca2+ decay, which were abrogated by adiponectin treatment. Ratios between phosphorylated c-Jun and c-Jun as well as phosphorylated IRS-1 and IRS-1 were increased in db/db mice, the effect of which was attenuated by adiponectin. Levels of the phosphorylated ER stress makers PERK (Thr980), IRE-1, and eIF2 alpha were significantly elevated in db/db mice compared with lean controls, although the effect was unaffected by adiponectin. Collectively, our data suggest that adiponectin improves cardiomyocyte dysfunction in db/db diabetic obese mice through a mechanism possibly related to c-Jun and IRS-1.
C1 [Dong, Feng; Ren, Jun] Univ Wyoming, Div Pharmaceut Sci, Laramie, WY 82071 USA.
   [Dong, Feng; Ren, Jun] Univ Wyoming, Ctr Cardiovasc Res & Alternat Med, Laramie, WY 82071 USA.
C3 University of Wyoming; University of Wyoming
RP Ren, J (corresponding author), Univ Wyoming, Div Pharmaceut Sci, Laramie, WY 82071 USA.
EM jren@uwyo.edu
RI Ren, Jun/ACG-5366-2022
OI Ren, Jun/0000-0002-0275-0783
FU American Heart Association Pacific Mountain Affiliate [0355521Z]; NIH
   University of Wyoming Northern Rockies Regional INBRE [5P20RR016474];
   American Heart Association (AHA) [0355521Z] Funding Source: American
   Heart Association (AHA)
FX We were grateful to Bonnie Zhao and Jennifer M. Nunn for their
   assistance in data analysis. This work was supported in part by grants
   from the American Heart Association Pacific Mountain Affiliate
   (0355521Z) and NIH University of Wyoming Northern Rockies Regional INBRE
   (5P20RR016474).
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NR 33
TC 45
Z9 48
U1 0
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1930-7381
EI 1930-739X
J9 OBESITY
JI Obesity
PD FEB
PY 2009
VL 17
IS 2
BP 262
EP 268
DI 10.1038/oby.2008.545
PG 7
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 400VJ
UT WOS:000262897200010
PM 19057532
DA 2025-06-11
ER

PT J
AU Scavuzzi, BM
   Simao, ANC
   Iriyoda, TMV
   Lozovoy, MAB
   Stadtlober, NP
   Santos, LFD
   Flauzino, T
   de Medeiros, FA
   de Sá, MC
   Consentin, L
   Reiche, EMV
   Maes, M
   Dichi, I
AF Scavuzzi, Bruna Miglioranza
   Colado Simao, Andrea Name
   Veiga Iriyoda, Tatiana Mayumi
   Batisti Lozovoy, Marcell Alysson
   Stadtlober, Nicole Perugini
   da Rosa Franchi Santos, Lorena Flor
   Flauzino, Tamires
   de Medeiros, Fabiano Aparecido
   de Sa, Marcelo Candido
   Consentin, Luana
   Vissoci Reiche, Edna Maria
   Maes, Michael
   Dichi, Isaias
TI Increased lipid and protein oxidation and lowered anti-oxidant defenses
   in systemic lupus erythematosus are associated with severity of illness,
   autoimmunity, increased adhesion molecules, and Th1 and Th17 immune
   shift
SO IMMUNOLOGIC RESEARCH
LA English
DT Article
DE Systemic lupus erythematosus; Reactive oxygen and nitrogen species;
   Cytokines; Anti-oxidant; Adhesion molecules
ID DISEASE-ACTIVITY INDEX; GENDER-DIFFERENCES; METABOLIC SYNDROME; STRESS;
   CELLS; OVERWEIGHT; BIOMARKERS; ANTIBODIES; CYTOKINE; NITRATE
AB This study investigated nitro-oxidative stress in patients with systemic lupus erythematosus (SLE) in association with disease activity, immune-inflammatory biomarkers, and adhesion molecules. Two-hundred-four patients with SLE and 256 healthy volunteers were enrolled in this case-control study, which measured nitro-oxidative stress biomarkers, including lipid peroxides (LOOH), advanced oxidation protein products (AOPPs), nitric oxide metabolites (NOx), sulfhydryl (-SH) groups, products of deoxyribonucleic acid (DNA)/ribonucleic acid (RNA) oxidative degradation, and total radical-trapping anti-oxidant parameter (TRAP). Also measured were anti-nuclear antibodies (ANAs), antibodies against double-stranded DNA (dsDNA), plasma levels of diverse cytokines, C-reactive protein, and adhesion molecules. LOOH (p < 0.001) and AOPP (p < 0.001) were significantly higher, while TRAP was significantly lower (p < 0.001) in SLE patients than in controls. AOPP and LOOH were significantly and positively associated with SLE disease activity index (SLEDAI) scores, anti-nuclear antibodies, and antibodies against double-stranded DNA (anti-dsDNA) levels, while TRAP was significantly and inversely correlated with SLEDAI, ANA, and dsDNA antibody levels. There were significant positive associations between AOPP and LOOH and immune-inflammatory markers, indicating T helper (Th)-17 and Th1 bias and Th1 + Th17/Th2 ratio (p = 0.002 and p = 0.001, respectively). AOPP and LOOH (positively) and TRAP (inversely) were associated with adhesion molecule expression. A model predicting SLE was computed showing that, using LOOH, AOPP, NOx, adhesion molecules, and body mass index, 94.2% of the patients were correctly classified with a specificity of 91.5%. Increased nitro-oxidative stress takes part in the (auto)immune pathophysiology of SLE and modulates severity of illness and adhesion molecule expression.
C1 [Scavuzzi, Bruna Miglioranza; Flauzino, Tamires] Univ Londrina, Grad Program Hlth Sci, Londrina, Brazil.
   [Colado Simao, Andrea Name; Batisti Lozovoy, Marcell Alysson; Vissoci Reiche, Edna Maria] Univ Londrina, Dept Pathol Clin Anal & Toxicol, Avenida Robert Koch 60, BR-86038440 Londrina, Parana, Brazil.
   [Veiga Iriyoda, Tatiana Mayumi] Univ Londrina, Dept Rheumatol, Londrina, Brazil.
   [Stadtlober, Nicole Perugini; da Rosa Franchi Santos, Lorena Flor; Consentin, Luana] Univ Londrina, Grad Program Pathol Clin Anal & Toxicol, Londrina, Brazil.
   [de Medeiros, Fabiano Aparecido; de Sa, Marcelo Candido] Univ Londrina, Grad Program Clin & Lab Pathophysiol, Londrina, Brazil.
   [Maes, Michael] Deakin Univ, Sch Med, IMPACT Strateg Res Ctr, Geelong, Vic, Australia.
   [Dichi, Isaias] Univ Londrina, Dept Internal Med, Londrina, Brazil.
C3 Deakin University
RP Simao, ANC (corresponding author), Univ Londrina, Dept Pathol Clin Anal & Toxicol, Avenida Robert Koch 60, BR-86038440 Londrina, Parana, Brazil.
EM b_miglioranza@yahoo.com.br; deianame@yahoo.com.br;
   tatimayumi54@gmail.com; marcell_lozovoy@hotmail.com;
   ni_perugini@hotmail.com; lorenaflordarosa@yahoo.com.br;
   t.flauzino@hotmail.com; fbimedeiros@hotmail.com; mcs-fbq@hotmail.com;
   luana.biomed@hotmail.com; reiche@sercomtel.com.br;
   dr.michaelmaes@hotmail.com; dichi@sercomtel.com.br
RI Simão, Andrea/AAM-4892-2021; Reiche, EDNa/AAD-4186-2020; Maes,
   Michael/B-8546-2011; Scavuzzi, Bruna/AAK-7916-2020; Lozovoy,
   Marcell/AAM-4897-2021; Santos, Lorena/KIH-3856-2024; de Sá,
   Marcelo/AAK-9551-2020; Reiche, Edna Maria Vissoci/C-4102-2013
OI Candido de Sa, Marcelo/0000-0003-0168-569X; Maes,
   Michael/0000-0002-2012-871X; Miglioranza Scavuzzi,
   Bruna/0000-0001-9609-001X; Reiche, Edna Maria
   Vissoci/0000-0001-6507-2839
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NR 53
TC 26
Z9 26
U1 0
U2 5
PU HUMANA PRESS INC
PI TOTOWA
PA 999 RIVERVIEW DRIVE SUITE 208, TOTOWA, NJ 07512 USA
SN 0257-277X
EI 1559-0755
J9 IMMUNOL RES
JI Immunol. Res.
PD FEB
PY 2018
VL 66
IS 1
BP 158
EP 171
DI 10.1007/s12026-017-8960-9
PG 14
WC Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology
GA FV6DZ
UT WOS:000424672800016
PM 29185130
DA 2025-06-11
ER

PT J
AU Shephard, RJ
   Johnson, N
AF Shephard, Roy J.
   Johnson, Nathan
TI Effects of physical activity upon the liver
SO EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
LA English
DT Review
DE Diabetes mellitus; Fatty liver; Hepatic blood flow; Hepatic clearance;
   Metabolic syndrome; Obesity; Oxidative stress; Steatosis;
   Steato-hepatitis; Ultra-marathons
ID LIFE-STYLE INTERVENTION; HIGH-FAT-DIET; NONALCOHOLIC HEPATIC STEATOSIS;
   LOW-DENSITY-LIPOPROTEIN; METABOLIC RISK-FACTORS;
   GAMMA-GLUTAMYL-TRANSFERASE; OXIDATIVE STRESS MARKERS; FACTOR BINDING
   PROTEIN-3; TRAINING PREVENTS LIVER; SERUM ENZYME CHANGES
AB To review the responses of the liver to acute and chronic physical activity and to summarize relationships between physical activity and liver health.
   A systematic search of HealthStar/Ovid from 1975 through June of 2013, supplemented by articles from other sources.
   351 of 8,010 articles identified by HealthStar/Ovid were supplemented by 92 other papers; after focussing, the review was reduced to 435 citations. Prolonged acute exercise reduces hepatic blood flow, stimulating hepatic glycogenolysis, gluconeogenesis and synthesis of some proteins; however, lipid metabolism shows little change. Glutathione depletion suggests oxidative stress. Enzymes affecting carbohydrate metabolism are up-regulated, and lipogenic enzymes are down-regulated. The main triggers are humoral, but hepatic afferent nerves, cytokines, reactive oxygen species, and changes in hepatic blood flow may all play some role. Regular aerobic exercise training improves blood glucose control during exercise by increasing glycogen stores and up-regulating enzymes involved in gluconeogenesis and carbohydrate metabolism. Resistance to oxidant stress is generally increased by training. Lipogenic enzymes are down-regulated, and lipid metabolism is augmented. Modulations of insulin, insulin-like growth factor, glucagon and interleukin-6 may trigger the adaptive responses to training. Cross-sectional and longitudinal studies show that regular exercise can reduce hepatic fat, but the effect on circulating aminotransferases is unclear and the modality and dose of physical activity optimizing health benefits need clarification.
   Regular moderate physical activity enhances liver health. Adverse functional changes can develop if habitual activity is inadequate, and extremely prolonged competitive exercise may also be harmful, particularly under harsh environmental conditions.
C1 [Shephard, Roy J.] Univ Toronto, Fac Kinesiol & Phys Educ, Toronto, ON, Canada.
   [Johnson, Nathan] Univ Sydney, Fac Hlth Sci, Sydney, NSW 2006, Australia.
   [Johnson, Nathan] Univ Sydney, Boden Inst Obes Nutr Exercise & Eating Disorders, Sydney, NSW 2006, Australia.
C3 University of Toronto; University of Sydney; University of Sydney
RP Shephard, RJ (corresponding author), POB 521, Brackendale, BC V0N 1H0, Canada.
EM royjshep@shaw.ca
RI Johnson, Nathan/Q-3158-2016
OI Johnson, Nathan/0000-0002-3874-7092
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NR 434
TC 68
Z9 74
U1 0
U2 57
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1439-6319
EI 1439-6327
J9 EUR J APPL PHYSIOL
JI Eur. J. Appl. Physiol.
PD JAN
PY 2015
VL 115
IS 1
BP 1
EP 46
DI 10.1007/s00421-014-3031-6
PG 46
WC Physiology; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology; Sport Sciences
GA AY0NQ
UT WOS:000347293500001
PM 25366252
DA 2025-06-11
ER

PT J
AU Annuzzi, G
   Bozzetto, L
   Costabile, G
   Giacco, R
   Mangione, A
   Anniballi, G
   Vitale, M
   Vetrani, C
   Cipriano, P
   Della Corte, G
   Pasanisi, F
   Riccardi, G
   Rivellese, AA
AF Annuzzi, Giovanni
   Bozzetto, Lutgarda
   Costabile, Giuseppina
   Giacco, Rosalba
   Mangione, Anna
   Anniballi, Gaia
   Vitale, Marilena
   Vetrani, Claudia
   Cipriano, Paola
   Della Corte, Giuseppina
   Pasanisi, Fabrizio
   Riccardi, Gabriele
   Rivellese, Angela A.
TI Diets naturally rich in polyphenols improve fasting and postprandial
   dyslipidemia and reduce oxidative stress: a randomized controlled
   trial<SUP>1-3</SUP>
SO AMERICAN JOURNAL OF CLINICAL NUTRITION
LA English
DT Article
ID POLYUNSATURATED FATTY-ACIDS; CARDIOVASCULAR-DISEASE;
   SECONDARY-PREVENTION; FISH-OIL; HEALTH; RISK; INFLAMMATION; OVERWEIGHT;
   TEA; MEN
AB Background: The postprandial triglyceride-rich lipoprotein (TRL) concentration is a recognized independent cardiovascular disease risk factor. Diet is the natural approach for these postprandial alterations. Dietary polyphenols and long chain n-3 polyunsaturated fatty acids (LCn3s) are associated with a lower cardiovascular disease risk.
   Objective: This randomized controlled study evaluated, in persons with a high risk of cardiovascular disease, the effects of diets naturally rich in polyphenols and/or marine LCn3s on plasma TRLs and urinary 8-isoprostane concentrations, a biomarker of oxidative stress.
   Design: According to a 2 x 2 factorial design, 86 overweight/obese individuals with a large waist circumference and any other component of the metabolic syndrome were randomly assigned to an isoenergetic diet 1) poor in LCn3s and polyphenols, 2) rich in LCn3s, 3) rich in polyphenols, or 4) rich in LCn3s and polyphenols. The diets were similar in all other components. Before and after the 8-wk intervention, fasting and postmeal TRLs and 8-isoprostane concentrations in 24-h urine samples were measured.
   Results: Dietary adherence was good in all participants. Polyphenols significantly reduced fasting triglyceride concentrations (2-factor ANOVA) in plasma (P = 0.023) and large very-low-density lipoproteins (VLDLs) (P = 0.016) and postprandial triglyceride total area under the curve in plasma (P = 0.041) and large VLDLs (P = 0.004). LCn3s reduced postprandial chylomicron cholesterol and VLDL apolipoprotein B-48. The concentrations of urinary 8-isoprostane decreased significantly with the polyphenol-rich diets. Lipoprotein changes induced by the intervention significantly correlated with changes in 8-isoprostane.
   Conclusions: Diets naturally rich in polyphenols positively influence fasting and postprandial TRLs and reduce oxidative stress. Marine LCn3s reduce TRLs of exogenous origin. Through their effects on postprandial fipemia and oxidative stress, polyphenols may favorably affect cardiovascular disease risk. This trial was registered at clinicaltrials.gov as NCT00781365.
C1 [Annuzzi, Giovanni; Bozzetto, Lutgarda; Costabile, Giuseppina; Mangione, Anna; Anniballi, Gaia; Vitale, Marilena; Vetrani, Claudia; Cipriano, Paola; Della Corte, Giuseppina; Pasanisi, Fabrizio; Riccardi, Gabriele; Rivellese, Angela A.] Univ Naples Federico II, Dept Clin Med & Surg, I-80125 Naples, Italy.
   [Giacco, Rosalba] Inst Food Sci, Natl Res Council, Avellino, Italy.
C3 University of Naples Federico II; Consiglio Nazionale delle Ricerche
   (CNR); Istituto di Scienze dell' Alimentazione (ISA-CNR)
RP Annuzzi, G (corresponding author), Univ Naples Federico II, Dept Clin Med & Surg, Via Pansini 5, I-80125 Naples, Italy.
EM annuzzi@unina.it
RI Ciampalini, Paolo/K-4366-2016; Bozzetto, Lutgarda/E-6271-2012;
   Costabile, Giuseppina/K-4589-2016; Vitale, Marilena/J-1457-2014;
   Vetrani, Claudia/D-3306-2018; Pasanisi, Fabrizio/L-7437-2015
OI Vitale, Marilena/0000-0001-9951-4674; Bozzetto,
   Lutgarda/0000-0001-6549-4476; Vetrani, Claudia/0000-0001-8335-5939;
   Giacco, Rosalba/0000-0002-4006-9761; Costabile,
   Giuseppina/0000-0001-5761-8002; Pasanisi, Fabrizio/0000-0003-4224-7821
FU Etherpaths Project [FP7-KBBE-222639]; "Foresid," Italian Society of
   Diabetology; Italian Diabetes Society: "Borsa di studio annuale SID-AMD
   Pasquale Di Coste
FX The research leading to these results received funding from the European
   Community's Seventh Framework Programme FP712009-2012 under grant
   agreement FP7-KBBE-222639, Etherpaths Project. GC was a recipient of a
   grant from "Foresid," Italian Society of Diabetology. LB received a
   research grant from the Italian Diabetes Society: "Borsa di studio
   annuale SID-AMD Pasquale Di Coste." Food for the study was kindly
   supplied by Lavazza, Torino, Italy (coffee); Nestle, Vevey, Switzerland
   (chocolate); Parmalat S.p.A., Parma, Italy (juice); Zuegg
   S.p.A.,.Verona, Italy (jam); Pompadour Te S.r.l., Bolzano, Italy (tea);
   and Coop. Nuovo Cilento s.c.r.l., San Mauro Cilento, Salerno, Italy
   (extra-virgin olive oil).
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NR 30
TC 118
Z9 124
U1 1
U2 30
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0002-9165
EI 1938-3207
J9 AM J CLIN NUTR
JI Am. J. Clin. Nutr.
PD MAR
PY 2014
VL 99
IS 3
BP 463
EP 471
DI 10.3945/ajcn.113.073445
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA AB9VN
UT WOS:000332143900008
PM 24368433
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Le Dour, C
   Schneebeli, S
   Bakiri, F
   Darcel, F
   Jacquemont, ML
   Maubert, MA
   Auclair, M
   Jeziorowska, D
   Reznik, Y
   Béréziat, V
   Capeau, J
   Lascols, O
   Vigouroux, C
AF Le Dour, Caroline
   Schneebeli, Stephane
   Bakiri, Fawzi
   Darcel, Francoise
   Jacquemont, Marie-Line
   Maubert, Marie-Anne
   Auclair, Martine
   Jeziorowska, Dorota
   Reznik, Yves
   Bereziat, Veronique
   Capeau, Jacqueline
   Lascols, Olivier
   Vigouroux, Corinne
TI A Homozygous Mutation of Prelamin-A Preventing Its Farnesylation and
   Maturation Leads to a Severe Lipodystrophic Phenotype: New Insights into
   the Pathogenicity of Nonfarnesylated Prelamin-A
SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Article
ID LAMIN A/C GENE; FAMILIAL PARTIAL LIPODYSTROPHY;
   HUTCHINSON-GILFORD-PROGERIA; INSULIN-RESISTANCE SYNDROME; MOUSE MODEL;
   MISSENSE MUTATIONS; DUNNIGAN VARIETY; PRE-LAMIN; DISEASE; CARDIOMYOPATHY
AB Context: Mutations in LMNA, encoding A-type lamins, lead to multiple laminopathies, including lipodystrophies, progeroid syndromes, and cardiomyopathies. Alterations in the prelamin-A posttranslational maturation, resulting in accumulation of farnesylated isoforms, cause human progeroid syndromes. Accumulation of mutant nonfarnesylated prelamin-A leads to cardiomyopathy or progeria in mice, but no data have been provided in humans.
   Objective, Design, Setting, and Patients: We searched for LMNA mutations in seven women originating from Reunion Island who were referred for a severe lipodystrophic syndrome. Clinical, molecular, genealogical, and cellular studies were performed in probands and relatives.
   Results: The seven probands showed a severe partial lipodystrophic syndrome with diabetes and/or acanthosis nigricans, liver steatosis, hypertriglyceridemia, and low serum leptin and adiponectin levels. Three probands also had severe cardiac rhythm and conduction disturbances. We identified in all probands a homozygousLMNAp.T655fsX49 mutation leading to expression of a mutated prelamin-A with 48 aberrant C-terminal amino acids, preventing its physiological posttranslational farnesylation and maturation. Genealogical and haplotype analyses were consistent with a founder mutation transmitted from a common ancestor in the 17th century. In probands' cultured fibroblasts, mutated prelamin-A was associated with typical laminopathic nuclear dysmorphies, increased oxidative stress, and premature senescence. Heterozygous relatives were asymptomatic or partially affected, in favor of a codominant transmission of the disease with incomplete penetrance in heterozygotes.
   Conclusions: We reveal that a homozygous mutation of prelamin-A preventing its farnesylation leads to a severe lipodystrophic laminopathy in humans, which can be associated with cardiac conduction disturbances, stressing the pathogenicity of nonfarnesylated prelamin-A in human laminopathies. (J Clin Endocrinol Metab 96: E856-E862, 2011)
C1 [Le Dour, Caroline; Auclair, Martine; Bereziat, Veronique; Capeau, Jacqueline; Lascols, Olivier; Vigouroux, Corinne] Ctr Rech St Antoine, INSERM, UMR S938, F-75012 Paris, France.
   [Le Dour, Caroline; Auclair, Martine; Bereziat, Veronique; Capeau, Jacqueline; Lascols, Olivier; Vigouroux, Corinne] Univ Paris 06, UMR S938, F-75005 Paris, France.
   [Maubert, Marie-Anne] Equipe Rech Labellisee, UMR 7203, U1057, F-75005 Paris, France.
   [Schneebeli, Stephane] Grp Hosp Sud Reunion, Serv Endocrinol & Malad Metab, F-97432 St Pierre, Reunion, France.
   [Darcel, Francoise] Grp Hosp Sud Reunion, Serv Neurol, F-97432 St Pierre, Reunion, France.
   [Jacquemont, Marie-Line] Grp Hosp Sud Reunion, Serv Neonatol, F-97432 St Pierre, Reunion, France.
   [Bakiri, Fawzi] Ctr Hosp Felix Guyon, Serv Diabetol Endocrinol, F-97400 St Denis, Reunion, France.
   [Reznik, Yves] CHU Cote Nacre, Serv Endocrinol & Malad Metab, F-14033 Caen, France.
   [Maubert, Marie-Anne; Jeziorowska, Dorota; Lascols, Olivier] Hop St Antoine, AP HP, Lab Commun Biol & Genet Mol, F-75012 Paris, France.
   [Capeau, Jacqueline; Vigouroux, Corinne] Hop Tenon, AP HP, Serv Biochim & Hormonol, F-75020 Paris, France.
C3 Sorbonne Universite; Institut National de la Sante et de la Recherche
   Medicale (Inserm); Sorbonne Universite; Institut National de la Sante et
   de la Recherche Medicale (Inserm); Centre National de la Recherche
   Scientifique (CNRS); CNRS - Institute of Chemistry (INC); CHU Reunion;
   CHU Reunion; CHU Reunion; CHU Reunion; CHU de Caen NORMANDIE; Universite
   de Caen Normandie; Assistance Publique Hopitaux Paris (APHP); Sorbonne
   Universite; Hopital Universitaire Saint-Antoine - APHP; Assistance
   Publique Hopitaux Paris (APHP); Sorbonne Universite; Hopital
   Universitaire Tenon - APHP
RP Vigouroux, C (corresponding author), Univ Paris 06, INSERM, Fac Med, UMR S938, Site St Antoine,27 Rue Chaligny, F-75571 Paris 12, France.
EM corinne.vigouroux@inserm.fr
RI Le Dour, Caroline/LIG-7650-2024
OI Le Dour, Caroline/0000-0001-8647-3252; BEREZIAT,
   Veronique/0000-0002-9795-549X; Auclair, Martine/0000-0003-3600-1999
FU French Institut National de la Sante et de la Recherche Medicale;
   European Union [LSHM-CT-2005-018690]; French Ministere de l'Enseignement
   Superieur et de la Recherche; French Institut National de la Sante et de
   la Recherche Medicale; European Union [LSHM-CT-2005-018690]; French
   Ministere de l'Enseignement Superieur et de la Recherche
FX This work was supported by grants from the French Institut National de
   la Sante et de la Recherche Medicale and the European Union's FP6 Life
   Science, Genomics, and Biotechnology for Health LSHM-CT-2005-018690
   ("Eurolaminopathies"). C.L.D. was granted by the French Ministere de
   l'Enseignement Superieur et de la Recherche.
CR Antuna-Puente B, 2010, J CLIN ENDOCR METAB, V95, P1463, DOI 10.1210/jc.2009-1824
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NR 28
TC 37
Z9 38
U1 0
U2 2
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0021-972X
EI 1945-7197
J9 J CLIN ENDOCR METAB
JI J. Clin. Endocrinol. Metab.
PD MAY
PY 2011
VL 96
IS 5
BP E856
EP E862
DI 10.1210/jc.2010-2234
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 759AE
UT WOS:000290210600015
PM 21346069
OA Bronze
DA 2025-06-11
ER

PT J
AU Rani, K
   Kaur, G
   Ali, SA
AF Rani, Kavita
   Kaur, Gurjeet
   Ali, Syed Azmal
TI Probiotic-prebiotic therapeutic potential: A new horizon of microbial
   biotherapy to reduce female reproductive complications
SO PHARMANUTRITION
LA English
DT Article
DE Synbiotic; Stress; Infertility; Reproduction; Obesity
ID CHAIN FATTY-ACIDS; GUT MICROBIOME; LACTOBACILLUS-RHAMNOSUS; CHILD
   OUTCOMES; CYCLIC-AMP; BUTYRATE; STRESS; HEALTH; ACTIVATION; MECHANISMS
AB Background: Probiotics and associated prebiotics have emerged as a novel method for treating health issues in the last two decades. It has been shown that they can regulate the gut microbiota through different molecular mechanisms. Inappropriate lifestyle choices activate the hypothalamic-pituitary-adrenal axis, resulting in immense stress. This leads to an increased incidence of patients with metabolic syndrome and an altered gut microbiota further lead to gastrointestinal dysbiosis. Microbial dysbiosis can disrupt the control and synthesis of reproductive hormones, thus leading to infertility. Methods: In this review, we gathered information from recent studies that show how probiotics and prebiotics could help support the treatment of reproductive disorders and hormone imbalances. We discussed the biochemical effects and proposed mechanisms of action of probiotics and prebiotics that may help with infertility in humans, as well as how these functional foods could be used to treat reproductive disorders. Results: Probiotics could restore fertility because their metabolites trigger the release of signaling molecules that control hormone production in intestinal epithelial cells and other organs. The review provides a collection of evidence that the use of probiotics and prebiotics could be a new horizon of microbial biotherapy to reduce female reproductive complications. Conclusions: Probiotics and prebiotics may offer a new approach to treat reproductive disorders and infertility by regulating gut microbiota and restoring the control and synthesis of reproductive hormones. The potential of using these functional foods as a microbial biotherapy to alleviate female reproductive complications warrants further investigation.
C1 [Rani, Kavita] ICAR NDRI, Anim Biochem Div, Karnal 132001, India.
   [Kaur, Gurjeet] Univ New South Wales, Ctr Hlth Brain Ageing, Sch Psychiat, Sydney, NSW 2052, Australia.
   [Kaur, Gurjeet] Univ New South Wales, Mark Wainwright Analyt Ctr, Bioanalyt Mass Spectrometry Facil, Sydney, NSW 2052, Australia.
   [Ali, Syed Azmal] German Canc Res Ctr, Div Prote Stem Cells & Canc, D-69120 Heidelberg, Germany.
   [Ali, Syed Azmal] German Canc Res Ctr, Div Prote Stem Cells & Canc, Heidelberg, Germany.
C3 Indian Council of Agricultural Research (ICAR); ICAR - National Dairy
   Research Institute; University of New South Wales Sydney; University of
   New South Wales Sydney; Helmholtz Association; German Cancer Research
   Center (DKFZ); Helmholtz Association; German Cancer Research Center
   (DKFZ)
RP Ali, SA (corresponding author), German Canc Res Ctr, Div Prote Stem Cells & Canc, Heidelberg, Germany.
EM syed.ali@dkfz-heidelberg.de
RI Ali, Syed Azmal/AAM-9532-2021
OI Malik, Kavita Rani/0000-0001-7029-8947; Kaur,
   Gurjeet/0000-0003-3322-5030; Ali, Syed Azmal/0000-0003-3024-9379
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NR 103
TC 6
Z9 6
U1 0
U2 7
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2213-4344
J9 PHARMANUTRITION
JI PharmaNutrition
PD JUN
PY 2023
VL 24
AR 100342
DI 10.1016/j.phanu.2023.100342
EA APR 2023
PG 10
WC Chemistry, Medicinal; Geriatrics & Gerontology; Gerontology; Nutrition &
   Dietetics; Pharmacology & Pharmacy
WE Emerging Sources Citation Index (ESCI)
SC Pharmacology & Pharmacy; Geriatrics & Gerontology; Nutrition & Dietetics
GA G4CE5
UT WOS:000988647400001
DA 2025-06-11
ER

PT J
AU Annunziata, G
   Capó, X
   Quetglas-Llabrés, MM
   Monserrat-Mesquida, M
   Tejada, S
   Tur, JA
   Ciampaglia, R
   Guerra, F
   Maisto, M
   Tenore, GC
   Novellino, E
   Sureda, A
AF Annunziata, Giuseppe
   Capo, Xavier
   Quetglas-Llabres, Maria Magdalena
   Monserrat-Mesquida, Margalida
   Tejada, Silvia
   Tur, Josep A.
   Ciampaglia, Roberto
   Guerra, Fabrizia
   Maisto, Maria
   Tenore, Gian Carlo
   Novellino, Ettore
   Sureda, Antoni
TI Ex Vivo Study on the Antioxidant Activity of a Winemaking By-Product
   Polyphenolic Extract (Taurisolo(R) on Human Neutrophils
SO ANTIOXIDANTS
LA English
DT Article
DE oxidative stress; agri-food by-products; polyphenols; nutraceutical;
   grape; blood cells
ID OXIDATIVE STRESS; HORMESIS; OBESITY; MYELOPEROXIDASE; RESVERATROL;
   CHOLESTEROL; FLAVONOIDS; SEPARATION; PHENOLICS; PROTEINS
AB Oxidative stress (OxS) has been linked to several chronic diseases and is recognized to have both major causes and consequences. The use of antioxidant-based nutraceuticals has been licensed as an optimal tool for management of OxS-related diseases. Currently, great interest is focused on the valorization of agri-food by-products as a source of bioactive compounds, including polyphenols. In this sense, we evaluated the efficacy of a novel nutraceutical formulation based on polyphenolic extract from Aglianico cultivar grape pomace (registered as Taurisolo(R)). In particular, we tested both native and in vitro gastrointestinal digested forms. The two extracts have been used to treat ex vivo neutrophils from subjects with metabolic syndrome, reporting a marked antioxidant activity of Taurisolo(R), as shown by its ability to significantly reduce both the levels of reactive oxygen species (ROS) and the activities of catalase and myeloperoxidase in the cell medium after stimulation of neutrophils with phorbol 12-myristate 13-acetate (PMA). Interestingly, we observed an increase in intracellular enzymatic activities in PMA-treated cells, suggesting that Taurisolo(R) polyphenols might be able to activate nuclear factors, up-regulating the expression of this target antioxidant gene. In addition, Taurisolo(R) reversed the increase in malondialdehyde induced by PMA; reduced the expression of pro-inflammatory genes such as cyclooxygenase 2 (COX-2), tumor necrosis factor alpha (TNF alpha) and myeloperoxidase (MPO); and induced the expression of the anti-inflammatory cytokine IL-10. Overall, these results suggest the efficacy of Taurisolo(R) in contrasting the OxS at blood level, providing evidence for its therapeutic potential in the management of OxS-related pathological conditions in humans.
C1 [Annunziata, Giuseppe; Ciampaglia, Roberto; Guerra, Fabrizia; Maisto, Maria; Tenore, Gian Carlo] Univ Naples Federico II, Dept Pharm, NutraPharmaLabs, Via Domenico Montesano 49, I-80131 Naples, Italy.
   [Capo, Xavier; Quetglas-Llabres, Maria Magdalena; Monserrat-Mesquida, Margalida; Tejada, Silvia; Tur, Josep A.; Sureda, Antoni] Univ Balear Islands, Res Grp Community Nutr & Oxidat Stress & Hlth Res, IUNICS, E-07122 Palma de Mallorca, Spain.
   [Monserrat-Mesquida, Margalida; Tejada, Silvia; Tur, Josep A.; Sureda, Antoni] Inst Salud Carlos III, CIBEROBN Physiopathol Obes & Nutr, Madrid 28029, Spain.
   [Tejada, Silvia] Univ Balear Islands, Neurophysiol Lab, Dept Biol, E-07122 Palma de Mallorca, Spain.
   [Tejada, Silvia] Univ Balear Islands, Hlth Res Inst Balear Islands IdISBa, E-07122 Palma de Mallorca, Spain.
   [Novellino, Ettore] NGN Healthcare New Generat Nutraceut Srl, Torrette Via Nazl 207, I-83013 Mercogliano, Italy.
C3 University of Naples Federico II; Universitat de les Illes Balears;
   IUNICS; Instituto de Salud Carlos III; CIBER - Centro de Investigacion
   Biomedica en Red; CIBEROBN
RP Tenore, GC (corresponding author), Univ Naples Federico II, Dept Pharm, NutraPharmaLabs, Via Domenico Montesano 49, I-80131 Naples, Italy.
EM giuseppe.annunziata@unina.it; xavier.capo@uib.es; m.quetglas@uib.es;
   margalida.monserrat@uib.es; silvia.tejada@uib.es; pep.tur@uib.es;
   roberto.ciampaglia@unina.it; fabrizia.guerra@unina.it;
   maria.maisto@unina.it; giancarlo.tenore@unina.it;
   ngnhealthcare@gmail.com; antoni.sureda@uib.es
RI Capó, Xavier/AAD-6322-2022; Mesquida, Margalida/AAB-4773-2019; Tur,
   Josep/AAE-5748-2020; Tejada, Silvia/L-7297-2014; Annunziata,
   Giuseppe/W-2529-2019; Sureda, Antoni/N-9588-2019; Quetglas Llabrés,
   Maria/AAA-4412-2019; Tur, Josep/F-5576-2014
OI Capo Fiol, Xavier/0000-0002-3499-5494; Tur, Josep/0000-0002-6940-0761;
   Maisto, Maria/0000-0002-0340-2254; Monserrat Mesquida,
   Margalida/0000-0002-8856-135X; Annunziata, Giuseppe/0000-0002-1922-662X;
   , Antoni/0000-0001-8656-6838; CIAMPAGLIA, ROBERTO/0000-0002-8734-4249
FU Instituto de Salud Carlos III through the Fondo de Investigacion para la
   Salud (FIS) - European Regional Development Fund [PI17/01827, PI20/00456
   CIBEROBN CB12/03/30038]
FX This research was funded by Instituto de Salud Carlos III through the
   Fondo de Investigacion para la Salud (FIS), which is cofunded by the
   European Regional Development Fund (Projects PI17/01827, PI20/00456
   CIBEROBN CB12/03/30038).
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NR 63
TC 10
Z9 10
U1 0
U2 8
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD JUL
PY 2021
VL 10
IS 7
AR 1009
DI 10.3390/antiox10071009
PG 16
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA UB9JE
UT WOS:000686153000001
PM 34201732
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Ho, G
   Takamatsu, Y
   Wada, R
   Sugama, S
   Waragai, M
   Takenouchi, T
   Masliah, E
   Hashimoto, M
AF Ho, Gilbert
   Takamatsu, Yoshiki
   Wada, Ryoko
   Sugama, Shuei
   Waragai, Masaaki
   Takenouchi, Takato
   Masliah, Eliezer
   Hashimoto, Makoto
TI Connecting Alzheimer's Disease With Diabetes Mellitus Through
   Amyloidogenic Evolvability
SO FRONTIERS IN AGING NEUROSCIENCE
LA English
DT Article
DE Alzheimer&#8217; s disease; diabetes mellitus; evolvability;
   antagonistic pleiotropy; adiponectin paradox
ID D-RIBOSE; METABOLIC SYNDROME; INSULIN-RESISTANCE; BETA; ADIPONECTIN;
   AMYLIN; CATECHOLAMINES; EPIDEMIOLOGY; HYPERTENSION; PATHOGENESIS
AB Type 2 diabetes mellitus (T2DM) has been clearlylinked to oxidative stress and amylin amyloidosis in pancreatic beta-cells. Yet despite extensive investigation, the biological significance of this is not fully understood. Recently, we proposed that Alzheimer's disease (AD)-relevant amyloidogenic proteins (APs), such as amyloid-beta (A beta) and tau, might be involved in evolvability against diverse stressors in the brain. Given the analogous cellular stress environments shared by both T2DM and AD, the objective of this study is to explore T2DM pathogenesis from the viewpoint of amyloidogenic evolvability. Similar to AD-related APs, protofibrillar amylin might confer resistance against the multiple stressors in beta-cells and be transmitted to offspring to deliver stress information, in the absence of which, type 1 DM (T1DM) in offspring might develop. On the contrary, T2DM may be manifested through an antagonistic pleiotropy mechanism during parental aging. Such evolvability-associated processes might be affected by parental diabetic conditions, including T1DM and T2DM. Furthermore, the T2DM-mediated increase in AD risk during aging might be attributed to an interaction of amylin with AD-related APs through evolvability, in which amylin protofibrillar formation presumably caused by adiponectin (APN) resistance could increase protofibril formation of AD-related APs in evolvability and subsequently lead to T2DM promotion of AD through antagonistic pleiotropy in aging. This suggests that targeting APN combined with an anti-T2DM agent might be therapeutic against neurodegeneration. Collectively, T1DM and T2DM might be linked through amylin evolvability, and a better understanding of amyloidogenic evolvability might also reveal clues to therapeutic interventions for AD comorbid with T2DM.
C1 [Ho, Gilbert; Waragai, Masaaki] PCND Neurosci Res Inst, Poway, CA USA.
   [Takamatsu, Yoshiki; Wada, Ryoko; Hashimoto, Makoto] Tokyo Metropolitan Inst Med Sci, Tokyo, Japan.
   [Sugama, Shuei] Nippon Med Sch, Dept Physiol, Tokyo, Japan.
   [Takenouchi, Takato] Natl Agr & Food Res Org, Inst Agrobiol Sci, Tsukuba, Ibaraki, Japan.
   [Masliah, Eliezer] NIA, Div Neurosci, NIH, Bethesda, MD 20892 USA.
C3 Tokyo Metropolitan Institute of Medical Science; Nippon Medical School;
   National Agriculture & Food Research Organization - Japan; National
   Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA)
RP Hashimoto, M (corresponding author), Tokyo Metropolitan Inst Med Sci, Tokyo, Japan.
EM hashimoto-mk@igakuken.or.jp
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NR 79
TC 5
Z9 5
U1 0
U2 7
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1663-4365
J9 FRONT AGING NEUROSCI
JI Front. Aging Neurosci.
PD OCT 28
PY 2020
VL 12
AR 576192
DI 10.3389/fnagi.2020.576192
PG 9
WC Geriatrics & Gerontology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology; Neurosciences & Neurology
GA OP3YC
UT WOS:000588016400001
PM 33192467
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Oh, S
   Tanaka, K
   Tsujimoto, T
   So, R
   Shida, T
   Shoda, J
AF Oh, Sechang
   Tanaka, Kiyoji
   Tsujimoto, Takehiko
   So, Rina
   Shida, Takashi
   Shoda, Junichi
TI Regular Exercise Coupled to Diet Regimen Accelerates Reduction of
   Hepatic Steatosis and Associated Pathological Conditions in Nonalcoholic
   Fatty Liver Disease
SO METABOLIC SYNDROME AND RELATED DISORDERS
LA English
DT Article
ID INSULIN-RESISTANCE; CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME;
   OXIDATIVE STRESS; LEPTIN; OBESITY; PLASMA; JAPAN; RISK
AB Background: A diet regimen focusing on weight loss is still the most efficient treatment for nonalcoholic fatty liver disease (NAFLD). Recently, specific benefits of exercise against NAFLD independent of weight loss have been reported. Hence, combining exercise with diet-induced weight loss can be expected to have an additive benefit for NAFLD management. We evaluated the effectiveness of diet in conjunction with exercise (DE) compared with that of diet alone (D) on hepatic steatosis and its underlying pathophysiology.
   Methods: Data obtained from 72 obese, middle-aged men with NAFLD who completed a 3-month program of DE or D in 2011 and 2012 were analyzed. Subjects went through a comprehensive parameters analysis for the pathophysiology of NAFLD.
   Results: Subjects in the DE group, compared with those in the D group, elicited additive effects on the degree of hepatic steatosis (-82.6% vs. -60.0%) and body weight (-13.3% vs. -8.9%) accompanied by an improvement in serum marker levels: inflammation, ferritin (-16.1% vs. -2.1%); oxidative stress, lipid peroxidation (-31.8% vs. +4.8%); adipokine imbalance, adiponectin, and leptin (+27.4% vs. +2.6% and -74.4% vs. -30.2%). Consequently, subjects in the DE group achieved further attenuation of insulin resistance [homeostatsis model assessment of insulin resistance (HOMA-IR) (-63.6% vs. -40.0%)]. These observed additive benefits in the DE group were closely associated with the increased volume of physical activity.
   Conclusions: The addition of exercise to a diet regimen potentiates the benefits in NAFLD management through further improvement of hepatic steatosis, inflammatory and oxidative stress levels, and adipokine imbalance, thereby attenuating insulin resistance independent of detectable weight loss.
C1 [Oh, Sechang] Univ Tsukuba, Grad Sch Comprehens Human Sci, Tsukuba, Ibaraki 3058575, Japan.
   [Tanaka, Kiyoji; Tsujimoto, Takehiko; So, Rina] Univ Tsukuba, Fac Hlth & Sport Sci, Tsukuba, Ibaraki 3058575, Japan.
   [Shida, Takashi] Univ Tsukuba, Div Med Sci, Grad Sch Comprehens Human Sci, Tsukuba, Ibaraki 3058575, Japan.
   [Shoda, Junichi] Univ Tsukuba, Fac Med, Div Med Sci, Tsukuba, Ibaraki 3058575, Japan.
C3 University of Tsukuba; University of Tsukuba; University of Tsukuba;
   University of Tsukuba
RP Shoda, J (corresponding author), Univ Tsukuba, Fac Med, 1-1-1 Tennodai, Tsukuba, Ibaraki 3058575, Japan.
EM shodaj@md.tsukuba.ac.jp
RI Tsujimoto, Takehiko/AAD-4458-2022; Oh, Sechang/AAV-5502-2020
OI Tsujimoto, Takehiko/0000-0003-3187-5689
FU Ministry of Education, Culture, Sports, Science and Technology, Japan
   [23300250, 24390488]; Grants-in-Aid for Scientific Research [24650436,
   23300250, 24390488, 24659104, 23390318, 25293278, 25882006] Funding
   Source: KAKEN
FX This work was supported in part by Grants-in-Aid for Scientific Research
   from the Ministry of Education, Culture, Sports, Science and Technology,
   Japan (23300250, 24390488).
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NR 38
TC 30
Z9 33
U1 0
U2 8
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-4196
EI 1557-8518
J9 METAB SYNDR RELAT D
JI Metab. Syndr. Relat. Disord.
PD JUN
PY 2014
VL 12
IS 5
BP 290
EP 298
DI 10.1089/met.2013.0143
PG 9
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA AI9JV
UT WOS:000337249800007
PM 24689911
DA 2025-06-11
ER

PT J
AU Vlassara, H
   Uribarri, J
   Cai, WJ
   Goodman, S
   Pyzik, R
   Post, J
   Grosjean, F
   Woodward, M
   Striker, GE
AF Vlassara, Helen
   Uribarri, Jaime
   Cai, Weijing
   Goodman, Susan
   Pyzik, Renata
   Post, James
   Grosjean, Fabrizio
   Woodward, Mark
   Striker, Gary E.
TI Effects of Sevelamer on HbA1c, Inflammation, and Advanced Glycation End
   Products in Diabetic Kidney Disease
SO CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
LA English
DT Article
ID STAGE RENAL-DISEASE; OXIDANT STRESS; COLESEVELAM HYDROCHLORIDE; DIETARY
   GLYCOTOXINS; NEGATIVE REGULATION; METABOLIC SYNDROME; RISK; RESTRICTION;
   PROGRESSION; TYPE-1
AB Background and objectives Increased inflammation and oxidative stress may be caused by proteins and lipids modified by cytotoxic advanced glycation end products (AGEs) in food. Restricting food containing elevated AGEs improves these risk factors in diabetic CKD. Because diet adherence can be problematic, this study aimed to remove cytotoxic AGEs from food already ingested and to determine whether sevelamer carbonate sequesters cytotoxic AGEs in the gut, preventing their uptake and thereby reducing AGE-induced abnormalities.
   Design, setting, participants, & measurements This single-center, randomized, 2-month, open-label, intention-to-treat, crossover study compared sevelamer carbonate with calcium carbonate treatment in stage 2-4 diabetic CKD. Participants received 2 months of treatment with one drug, had a 1-week washout, and then received the opposite drug for 2 months.
   Results Sevelamer carbonate reduced HbA1c, serum methylglyoxal, serum N-epsilon-carboxymethyl-lysine, triglycerides, and 8-isoprostanes. Total cholesterol and fibroblast growth factor 23 were reduced by sevelamer carbonate, relative to calcium carbonate. AGE receptor 1 and sirtuin 1 mRNA were increased and PMNC TNF alpha levels were decreased by sevelamer carbonate, but not calcium carbonate. Medications and caloric and AGE intake remained unchanged. Sevelamer carbonate reversibly bound AGE-BSA at intestinal, but not stomach, pH.
   Conclusions Sevelamer carbonate significantly reduces HbA1c, fibroblast growth factor 23, lipids, and markers of inflammation and oxidative stress, and markedly increases antioxidant markers, independently of phosphorus in patients with diabetes and early kidney disease. These novel actions of sevelamer carbonate on metabolic and inflammatory abnormalities in type 2 diabetes mellitus may affect progression of early diabetic CKD. Clin J Am Soc. Nephrol 7: 934-942, 2012. doi: 10.2215/CJN.12891211
C1 [Vlassara, Helen; Cai, Weijing; Goodman, Susan; Pyzik, Renata; Grosjean, Fabrizio; Striker, Gary E.] Mt Sinai Sch Med, Div Expt Diabet & Aging, Dept Geriatr, New York, NY USA.
   [Uribarri, Jaime; Post, James; Striker, Gary E.] Mt Sinai Sch Med, Div Nephrol, Dept Med, New York, NY USA.
   [Post, James] Bronx Vet Adm Hosp, Bronx, NY USA.
   [Grosjean, Fabrizio] Dept Med, Div Nephrol, Pavia, Italy.
   [Woodward, Mark] Univ Sydney, George Inst, Sydney, NSW 2006, Australia.
C3 Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at
   Mount Sinai; University of Sydney; George Institute for Global Health
RP Striker, GE (corresponding author), Mt Sinai Med Ctr, 1 Gustave Levy Pl,Box 1640, New York, NY 10029 USA.
EM Gary.striker@mssm.edu
RI Uribarri, Jaime/ADX-7655-2022; Woodward, Mark/L-6817-2017
OI uribarri, jaime/0000-0001-9826-1134; Woodward, Mark/0000-0001-9800-5296
FU Genzyme Corporation
FX This independent investigator-initiated trial was funded by a contract
   from Genzyme Corporation to H.V.
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NR 48
TC 108
Z9 122
U1 0
U2 30
PU AMER SOC NEPHROLOGY
PI WASHINGTON
PA 1725 I ST, NW STE 510, WASHINGTON, DC 20006 USA
SN 1555-9041
EI 1555-905X
J9 CLIN J AM SOC NEPHRO
JI Clin. J. Am. Soc. Nephrol.
PD JUN
PY 2012
VL 7
IS 6
BP 934
EP 942
DI 10.2215/CJN.12891211
PG 9
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 954VE
UT WOS:000304975100010
PM 22461535
OA Green Published
DA 2025-06-11
ER

PT J
AU Jonassaint, CR
   Boyle, SH
   Kuhn, CM
   Siegler, IC
   Copeland, WE
   Williams, R
AF Jonassaint, Charles R.
   Boyle, Stephen H.
   Kuhn, Cynthia M.
   Siegler, Ilene C.
   Copeland, William E.
   Williams, Redford
TI PERSONALITY AND INFLAMMATION: THE PROTECTIVE EFFECT OF OPENNESS TO
   EXPERIENCE
SO ETHNICITY & DISEASE
LA English
DT Article
DE Coronary Heart Disease; C-reactive Protein; Openness to Experience
ID C-REACTIVE PROTEIN; CORONARY-HEART-DISEASE; CARDIOVASCULAR-DISEASE;
   RISK-FACTORS; METABOLIC SYNDROME; ALEXITHYMIA; STRESS; RACE;
   ASSOCIATION; HOSTILITY
AB Background: Prior research found reduced mortality in coronary heart patients with higher scores on the Openness to Experience domain and its facets. Decreased C-reactive protein level (CRP) levels may be one mechanism by which higher Openness to Experience leads to decreased mortality. Thus, the current study aimed to test the association between the Openness to Experience domain and its facets, as assessed by the NEO Personality Inventory-Revised, and CRP in a sample of 165 healthy Black and White, male and female community volunteers.
   Methods: Blood samples were taken before and after a 40-minute mental stress protocol. BMI and education were significant predictors of CRP and, in addition to age, were included as covariates in all analyses. Race and sex were tested as possible moderating variables.
   Results: In a mixed effects model the main effect of time (pre/post-stress), Openness to Experience (0) and their interaction were not significant predictors of CRP. However, results showed a significant race x 0 effect on CRP (P=.03). In Blacks, higher Openness to Experience domain (r=-.41, P<.01), aesthetics facet (r=-.30, P=.01), feelings facet (r=-.41, P<.01), and ideas facet (r=-.38, P<.01) scores were associated with lower mean CRP levels. in contrast, among White participants, neither the Openness to Experience domain nor its related facets were associated with CRP.
   Discussion: The Openness to Experience domain and its facets may be associated with markers of the inflammatory process among Blacks but not Whites. (Ethn Dis. 2010;20: 11-14)
C1 [Jonassaint, Charles R.; Boyle, Stephen H.; Kuhn, Cynthia M.; Siegler, Ilene C.; Copeland, William E.; Williams, Redford] Duke Univ, Med Ctr, Dept Psychiat & Behav Sci, Durham, NC 27706 USA.
C3 Duke University
RP Williams, R (corresponding author), 2212 Elder St, Durham, NC 27705 USA.
EM redfordw@duke.edu
RI Jonassaint, Charles/I-2772-2014; Copeland, William E/N-5413-2014
OI Jonassaint, Charles/0000-0002-5662-5806; Copeland, William
   E/0000-0002-1348-7781
FU National Heart, Lung and Blood Institute [P01-HL36587]; Duke Behavioral
   Medicine Research Center
FX This research was supported by the National Heart, Lung and Blood
   Institute grant P01-HL36587, and by the Duke Behavioral Medicine
   Research Center.
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NR 29
TC 23
Z9 27
U1 0
U2 11
PU INT SOC HYPERTENSION BLACKS-ISHIB
PI ATLANTA
PA 100 AUBURN AVE NE STE 401, ATLANTA, GA 30303-2527 USA
SN 1049-510X
J9 ETHNIC DIS
JI Ethn. Dis.
PD WIN
PY 2010
VL 20
IS 1
BP 11
EP 14
PG 4
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA 549NJ
UT WOS:000274057600004
PM 20178176
DA 2025-06-11
ER

PT J
AU Oltman, CL
   Coppey, LJ
   Gellett, JS
   Davidson, EP
   Lund, DD
   Yorek, MA
AF Oltman, CL
   Coppey, LJ
   Gellett, JS
   Davidson, EP
   Lund, DD
   Yorek, MA
TI Progression of vascular and neural dysfunction in sciatic nerves of
   Zucker diabetic fatty and Zucker rats
SO AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
LA English
DT Article
DE diabetic neuropathy; vascular reactivity; oxidative stress; superoxide;
   type 2 diabetes; metabolic syndrome
ID GENE-RELATED PEPTIDE; INSULIN-RESISTANT RATS; ENDONEURIAL BLOOD-FLOW;
   OXIDATIVE STRESS; EPINEURIAL ARTERIOLES; ENDOTHELIAL DYSFUNCTION;
   CONDUCTION-VELOCITY; SUPEROXIDE-PRODUCTION; CORONARY-ARTERIES;
   GLUCOSE-TOLERANCE
AB We have examined the progression of vascular and neural deficits in Zucker rats, Zucker diabetic fatty (ZDF) diabetic rats, and age-matched lean ZDF rats from 8 to 40 wk of age. Both the ZDF diabetic and Zucker rats were glucose intolerant at 8 wk of age. The Zucker rats did not become hyperglycemic but were hyperinsulinemic through 32 wk of age. All ZDF diabetic rats became hyperglycemic by 8 wk of age. Through their life span, serum free fatty acids and triglycerides levels were significantly higher in Zucker and ZDF diabetic rats compared with age-matched lean ZDF rats. After 24 and 28 wk of age, endoneurial blood flow was significantly decreased in ZDF diabetic and Zucker rats. Motor nerve conduction velocity was significantly decreased after 12-14 wk of age in ZDF diabetic rats and at 32 wk of age in Zucker rats. ACh-mediated vascular relaxation of epineurial arterioles of the sciatic nerve was impaired after 8-10 wk of age in ZDF diabetic rats and after similar to 16 wk of age in Zucker rats. In contrast, vascular relaxation mediated by calcitonin gene-related peptide was impaired significantly after 28 wk of age in ZDF diabetic rats but not impaired in Zucker rats up to 40 wk of age. Markers of oxidative stress were differentially elevated in ZDF diabetic rats and Zucker rats. These data indicate that vascular and neural dysfunction develops in both Zucker and ZDF diabetic rats but at different rates, which may be the result of hyperglycemia.
C1 Univ Iowa, Vet Affairs Med Ctr, Iowa City, IA 52246 USA.
   Univ Iowa, Dept Internal Med, Iowa City, IA 52246 USA.
C3 University of Iowa; US Department of Veterans Affairs; Veterans Health
   Administration (VHA); Iowa City VA Health Care System; University of
   Iowa
RP Univ Iowa, Vet Affairs Med Ctr, 3 E 17, Iowa City, IA 52246 USA.
EM mark-yorek@uiowa.edu
RI Yorek, Mark/AAC-3136-2021
OI Yorek, Mark/0000-0001-7737-5554
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NR 50
TC 103
Z9 119
U1 0
U2 7
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0193-1849
EI 1522-1555
J9 AM J PHYSIOL-ENDOC M
JI Am. J. Physiol.-Endocrinol. Metab.
PD JUL
PY 2005
VL 289
IS 1
BP E113
EP E122
DI 10.1152/ajpendo.00594.2004
PG 10
WC Endocrinology & Metabolism; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Physiology
GA 939ZR
UT WOS:000230113600017
PM 15727946
DA 2025-06-11
ER

PT J
AU Antunes, KA
   Monteiro-Alfredo, T
   Cunha, JSM
   Espindola, PPT
   Oliveira, AS
   de Oliveira, CFR
   de Carvalho, JTG
   Domingues, NLC
   Silva, DB
   Olinto, SCF
   dos Santos, EL
   Souza, KD
AF Antunes, Katia A.
   Monteiro-Alfredo, Tamaeh
   Cunha, Janielle S. M.
   Espindola, Priscila P. T.
   Oliveira, Alex S.
   de Oliveira, Caio F. Ramalho
   de Carvalho, Jose Tarcisio G.
   Domingues, Nelson L. C.
   Silva, Denise B.
   Olinto, Silvia C. F.
   dos Santos, Edson L.
   Souza, Kely de Picoli
TI RETRACTED: Spondias purpurea L. Bark Extract Protects against
   Oxidative Stress and Reduces Hypercholesterolemia in Mice Fed High-Fat
   Diet (Retracted Article)
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Article; Retracted Publication
ID FREE-RADICALS; ANTIOXIDANTS; OBESITY; MECHANISM; REDUCTASE; LEAVES
AB Oxidative stress plays a key role in the initiation and progression of metabolic diseases, including obesity. Preventing the accumulation of reactive oxygen species and oxidative damage to macromolecules is a beneficial strategy for reducing comorbidities associated with obesity. Fruits from the Spondias genus are known for their antioxidant activity, but they are not available year-round due to their seasonality. In this context, we investigated the antioxidant activity and identified the chemical constituents of the aqueous extract of the stem bark of Spondias purpurea L. (EBSp). Additionally, we evaluated the effect of EBSp consumption on metabolic parameters in mice with obesity induced by a high-fat diet. Chemical analyses revealed 19 annotated compounds from EBSp, including flavan-3-ols, proanthocyanidins, methoxylated coumarin, and gallic and ellagic acids, besides other phenolic compounds. In vitro, EBSp showed antioxidant activity through the scavenging of the free radicals and the protection of macromolecules against oxidative damage. Cellular assays revealed that EBSp reduced the levels of malondialdehyde produced by erythrocytes exposed to the oxidizing agent AAPH. Flow cytometry studies showed that EBSp reduced reactive oxygen species levels in human peripheral blood mononuclear cells treated with hydrogen peroxide. Obese mice treated with EBSp (400 mg.kg(-1)) for 60 days showed reduced levels of malondialdehyde in the heart, liver, kidneys, and nervous system. The total cholesterol levels in mice treated with EBSp reached levels similar to those after treatment with the drug simvastatin. Together, the results show that the combination of the different phenolic compounds in S. purpurea L. bark promotes antioxidant effects in vitro and in vivo, resulting in cytoprotection in the context of oxidative stress associated with obesity and a reduction in hypercholesterolemia. From a clinical perspective, the reduction in oxidative stress in obese individuals contributes to the reduction in the emergence of comorbidities associated with this metabolic syndrome.
C1 [Antunes, Katia A.; Monteiro-Alfredo, Tamaeh; Espindola, Priscila P. T.; Oliveira, Alex S.; de Oliveira, Caio F. Ramalho; de Carvalho, Jose Tarcisio G.; Domingues, Nelson L. C.; Olinto, Silvia C. F.; dos Santos, Edson L.; Souza, Kely de Picoli] Fed Univ Grande Dourados, Res Grp Biotechnol & Bioprospecting Appl Metab, Dourados, MS, Brazil.
   [Cunha, Janielle S. M.] Univ Fed Amapa, Amapa, Brazil.
   [Silva, Denise B.] Univ Fed Mato Grosso do Sul, Lab Nat Prod & Mass Spectrometry, Campo Grande, MS, Brazil.
C3 Universidade Federal da Grande Dourados; Fundacao Universidade Federal
   do Amapa; Universidade Federal de Mato Grosso do Sul
RP Souza, KD (corresponding author), Fed Univ Grande Dourados, Res Grp Biotechnol & Bioprospecting Appl Metab, Dourados, MS, Brazil.
EM kelypicoli@gmail.com
RI de Picoli Souza, Kely/I-1248-2015; Monteiro Alfredo, Tamaeh/G-5134-2018;
   Domingues, Nelson/A-2229-2014; cunha-filho, joao/AAU-9395-2020; Santos,
   Edson/C-6820-2014; da Silva, Denise/G-1460-2012
OI Santos Oliveira, Alex/0000-0002-2097-6655; da Silva,
   Denise/0000-0003-0872-2756; /0000-0002-6557-7914; Monteiro Alfredo,
   Tamaeh/0000-0001-5514-0797
FU Support Foundation for the Development of Teaching, Science and
   Technology of Mato Grosso do Sul (FUNDECT); National Council for
   Scientific and Technological Development (CNPq); Brazilian Federal
   Agency for the Support and Evaluation of Graduate Education (CAPES);
   Federal University Foundation of Grande Dourados (UFGD)
FX This study was funded by the Support Foundation for the Development of
   Teaching, Science and Technology of Mato Grosso do Sul (FUNDECT), the
   National Council for Scientific and Technological Development (CNPq),
   the Brazilian Federal Agency for the Support and Evaluation of Graduate
   Education (CAPES), and the Federal University Foundation of Grande
   Dourados (UFGD).
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NR 45
TC 3
Z9 4
U1 1
U2 9
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PD MAR 31
PY 2022
VL 2022
AR 3046483
DI 10.1155/2022/3046483
PG 13
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA 2T8VQ
UT WOS:000822746200003
PM 35401919
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Prasad, V
   Lorenz, JN
   Miller, ML
   Vairamani, K
   Nieman, ML
   Wang, YG
   Shull, GE
AF Prasad, Vikram
   Lorenz, John N.
   Miller, Marian L.
   Vairamani, Kanimozhi
   Nieman, Michelle L.
   Wang, Yigang
   Shull, Gary E.
TI Loss of NHE1 activity leads to reduced oxidative stress in heart and
   mitigates high-fat diet-induced myocardial stress
SO JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
LA English
DT Article
DE NHE-1; Slc9a1; Metabolic syndrome; Diabetes; Insulin resistance
ID NA+/H+ EXCHANGE INHIBITION; ALPHA-B-CRYSTALLIN; SODIUM-HYDROGEN
   EXCHANGER; H+ EXCHANGE; FUNCTIONAL EXPRESSION; INSULIN-RESISTANCE;
   PRESSURE-OVERLOAD; ENHANCED ACTIVITY; SHOCK PROTEINS; CA2+ OVERLOAD
AB Acute inhibition of the NHE1 Na+/H+ exchanger protects against ischemia-reperfusion injury and chronic inhibition attenuates development of cardiac hypertrophy and failure. To determine the cardiac effects of chronic inhibition of NHE1 under non-pathological conditions we used NHE1-null mice as a model of long-term NHE1 inhibition. Cardiovascular performance was relatively normal in Nhe1(-/-) mice although cardiac contractility and relaxation were slightly improved in mutant mice of the FVB/N background. GSH levels and GSH:GSSG ratios were elevated in Nhe1(-/-) hearts indicating an enhanced redox potential. Consistent with a reduced need for antioxidant protection, expression of heat shock proteins Hsp60 and Hsp25 was lower in Nhe1(-/-) hearts. Similarly, expression of mitochondrial superoxide dismutase 2 was reduced, with no increase in expression of other ROS scavenging enzymes. GLUT1 levels were increased in Nhe1(-/-) hearts, the number of lipid droplets in myocytes was reduced, and PDK4 expression was refractory to high-fat diet-induced upregulation observed in wild-type hearts. High-fat diet-induced stress was attenuated in Nhe1(-/-) hearts, as indicated by smaller increases in phosphorylation of Hsp25 and alpha-B crystallin, and there was better preservation of insulin sensitivity, as evidenced by PKB/Akt phosphorylation. Plasma glucose and insulin levels were lower and high-fat diet-induced hepatic lipid accumulation was reduced in Nhe1(-/-) mice, demonstrating extracardiac effects of NHE1 ablation. These data indicate that long-term ablation of NHE1 activity increases the redox potential, mitigates high-fat diet-induced myocardial stress and fatty liver disease, leads to better preservation of insulin sensitivity, and may alter both cardiac and systemic metabolic substrate handling in mice. (C) 2013 Elsevier Ltd. All rights reserved.
C1 [Prasad, Vikram; Vairamani, Kanimozhi; Shull, Gary E.] Univ Cincinnati, Coll Med, Dept Mol Genet Biochem & Microbiol, Cincinnati, OH 45267 USA.
   [Lorenz, John N.; Nieman, Michelle L.] Univ Cincinnati, Coll Med, Dept Mol & Cellular Physiol, Cincinnati, OH 45267 USA.
   [Miller, Marian L.] Univ Cincinnati, Coll Med, Dept Environm Hlth, Cincinnati, OH 45267 USA.
   [Wang, Yigang] Univ Cincinnati, Coll Med, Dept Pathol & Lab Med, Cincinnati, OH 45267 USA.
C3 University System of Ohio; University of Cincinnati; University System
   of Ohio; University of Cincinnati; University System of Ohio; University
   of Cincinnati; University System of Ohio; University of Cincinnati
RP Shull, GE (corresponding author), Univ Cincinnati, Coll Med, Dept Mol Genet Biochem & Microbiol, 231 Albert Sabin Way, Cincinnati, OH 45267 USA.
EM shullge@ucmail.uc.edu
OI Vairamani, Kanimozhi/0000-0002-1596-7762
FU NIH grants [HL061974, DK050594]; American Heart Association grant
   [11BGIA7720005]; Center for Environmental Genetics [P30ES006096]; U24
   grant [DK059630]; American Heart Association (AHA) [11BGIA7720005]
   Funding Source: American Heart Association (AHA)
FX This study was supported by NIH grants HL061974 and DK050594. VP was
   partially supported by the American Heart Association grant
   11BGIA7720005. MLM was supported by P30ES006096 (Center for
   Environmental Genetics). The Mouse Metabolic Phenotyping Center is
   supported by a U24 grant DK059630. We thank Maureen Bender for the
   excellent animal husbandry.
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NR 81
TC 34
Z9 39
U1 1
U2 18
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0022-2828
EI 1095-8584
J9 J MOL CELL CARDIOL
JI J. Mol. Cell. Cardiol.
PD DEC
PY 2013
VL 65
BP 33
EP 42
DI 10.1016/j.yjmcc.2013.09.013
PG 10
WC Cardiac & Cardiovascular Systems; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Cell Biology
GA 261TN
UT WOS:000327687600004
PM 24080184
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Chander, PN
   Gealekman, O
   Brodsky, SV
   Elitok, S
   Tojo, A
   Crabtree, M
   Gross, SS
   Goligorsky, MS
AF Chander, PN
   Gealekman, O
   Brodsky, SV
   Elitok, S
   Tojo, A
   Crabtree, M
   Gross, SS
   Goligorsky, MS
TI Nephropathy in Zucker diabetic fat rat is associated with oxidative and
   nitrosative stress: Prevention by chronic therapy with a peroxynitrite
   scavenger ebselen
SO JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
LA English
DT Article
ID NITRIC-OXIDE SYNTHASE; FOCAL SEGMENTAL GLOMERULOSCLEROSIS; ENDOTHELIAL
   DYSFUNCTION; INSULIN-RESISTANT; GLUTATHIONE DISULFIDE; SUPEROXIDE ANION;
   RENAL INJURY; TETRAHYDROBIOPTERIN; OBESITY; KIDNEY
AB Zucker diabetic fat (ZDF) rats with the metabolic syndrome and hyperlipidemia develop focal and segmental sclerosis. The role of oxidative and nitrosative stress in the nephropathy in ZDF was studied. Renal histology, function, and immunohistologic and biochemical parameters of oxidative and nitrosative stress were evaluated at 8 and 22 wk of age in ZDF and Zucker lean (ZL) rats and after chronic treatment with ebselen, an antioxidant and peroxinitrite scavenger. At 8 wk, ZDF rats showed hyperglycemia, no proteinuria or nephropathy, but higher levels of dihydrobiopterin and 3-nitrotyrosine (3-NT)-modified proteins compared with age-matched ZL rats. At 22 wk, ZDF rats developed focal and segmental sclerosis, proteinuria, decreased creatinine clearance, and renal tissue levels of glutathione and tetrahydrobiopterin with further elevation in dihydrobiopterin and 3-NT-modified proteins, in contrast to age-matched ZL rats. Renal immunohistologic expression of lipid peroxidation products and 3-NT-modified proteins also increased in 22-wk-old ZDF but not in ZL rats. Chronic ebselen treatment of ZDF rats restored renal tissue levels of glutathione and tetrahydrobiopterin; prevented significant accumulation of dihydrobiopterin, lipid peroxidation products, and 3-NT-modified proteins; and ameliorated focal and segmental sclerosis, proteinuria, and fall in creatinine clearance without affecting mean BP, body weight, and blood glucose, compared with the untreated ZDF rats. Chronic ebselen therapy also ameliorated vasculopathy with lipid deposits and tubulointerstitial scarring, inflammation, and upregulated alpha-smooth muscle actin expression. These findings suggest that ZDF rats develop a progressive nephropathy with glomerular, vascular, and tubulointerstitial pathology. Oxidative and nitrosative stress predates the nephropathy, which is improved by peroxinitrite scavenger ebselen, and thus considered its cause and not consequence.
C1 New York Med Coll, Dept Pathol, Valhalla, NY 10595 USA.
   New York Med Coll, Dept Med, Valhalla, NY 10595 USA.
   New York Med Coll, Renal Res Inst, Valhalla, NY 10595 USA.
   Univ Tokyo, Dept Med, Tokyo, Japan.
   Cornell Univ, Weill Med Coll, Dept Pharmacol, New York, NY USA.
C3 New York Medical College; New York Medical College; New York Medical
   College; Renal Research Institute; University of Tokyo; Cornell
   University; Weill Cornell Medicine
RP New York Med Coll, Dept Pathol, Valhalla, NY 10595 USA.
EM praveen_chander@nymc.edu
RI Crabtree, Mark/JLL-2815-2023; brodsky, sergey/AAU-3507-2021
OI Crabtree, Mark/0000-0003-3298-2697
FU NIDDK NIH HHS [DK 45695, DK 54602, DK 45462] Funding Source: Medline
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NR 53
TC 146
Z9 159
U1 0
U2 3
PU AMER SOC NEPHROLOGY
PI WASHINGTON
PA 1725 I ST, NW STE 510, WASHINGTON, DC 20006 USA
SN 1046-6673
EI 1533-3450
J9 J AM SOC NEPHROL
JI J. Am. Soc. Nephrol.
PD SEP
PY 2004
VL 15
IS 9
BP 2391
EP 2403
DI 10.1097/01.ASN.0000135971.88164.2C
PG 13
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 851EK
UT WOS:000223668200017
PM 15339988
OA Bronze
DA 2025-06-11
ER

PT J
AU Schiffer, TA
   Lundberg, JO
   Weitzberg, E
   Carlström, M
AF Schiffer, Tomas A.
   Lundberg, Jon O.
   Weitzberg, Eddie
   Carlstrom, Mattias
TI Modulation of mitochondria and NADPH oxidase function by the
   nitrate-nitrite-NO pathway in metabolic disease with focus on type 2
   diabetes
SO BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
LA English
DT Review
DE Mitochondria; Nitrate; Nitrite; Nitric oxide; Oxidative stress;
   Diabetes; Obesity; AMPK; SIRT3; Browning; Beiging
ID PROTEIN-KINASE ACTIVATION; DIETARY INORGANIC NITRATE; METFORMIN IMPROVES
   HYPERGLYCEMIA; WHITE ADIPOSE-TISSUES; ANGIOTENSIN-II; OXIDATIVE STRESS;
   SKELETAL-MUSCLE; BLOOD-PRESSURE; INSULIN-RESISTANCE; BROWN ADIPOCYTES
AB Mitochondria play fundamental role in maintaining cellular metabolic homeostasis, and metabolic disorders including type 2 diabetes (T2D) have been associated with mitochondrial dysfunction. Pathophysiological mechanisms are coupled to increased production of reactive oxygen species and oxidative stress, together with reduced bioactivity/signaling of nitric oxide (NO). Novel strategies restoring these abnormalities may have therapeutic potential in order to prevent or even treat T2D and associated cardiovascular and renal co-morbidities. A diet rich in green leafy vegetables, which contains high concentrations of inorganic nitrate, has been shown to reduce the risk of T2D. To this regard research has shown that in addition to the classical NO synthase (NOS) dependent pathway, nitrate from our diet can work as an alternative precursor for NO and other bioactive nitrogen oxide species via serial reductions of nitrate (i.e. nitrate-nitrite-NO pathway). This non-conventional pathway may act as an efficient back-up system during various pathological conditions when the endogenous NOS system is compromised (e.g. acidemia, hypoxia, ischemia, aging, oxidative stress). A number of experimental studies have demonstrated protective effects of nitrate supplementation in models of obesity, metabolic syndrome and T2D. Recently, attention has been directed towards the effects of nitrate/nitrite on mitochondrial functions including beiging/browning of white adipose tissue, PGC-1 alpha and SIRT3 dependent AMPK activation, GLUT4 translocation and mitochondrial fusion-dependent improvements in glucose homeostasis, as well as dampening of NADPH oxidase activity. In this review, we examine recent research related to the effects of bioactive nitrogen oxide species on mitochondrial function with emphasis on T2D.
C1 [Schiffer, Tomas A.; Lundberg, Jon O.; Weitzberg, Eddie; Carlstrom, Mattias] Karolinska Inst, Dept Physiol & Pharmacol, Stockholm, Sweden.
   [Weitzberg, Eddie] Karolinska Univ Hosp, Dept Perioperat Med & Intens Care, Stockholm, Sweden.
C3 Karolinska Institutet; Karolinska Institutet; Karolinska University
   Hospital
RP Schiffer, TA; Carlström, M (corresponding author), Karolinska Inst, Dept Physiol & Pharmacol, Solnavagen 9,Biomed 5B, S-17165 Solna, Sweden.
EM tomas.schiffer@ki.se; mattias.carlstrom@ki.se
RI Schiffer, Tomas/X-1343-2018; Carlstrom, Mattias/E-7350-2015
OI Lundberg, Jon/0000-0002-0174-5210; Carlstrom,
   Mattias/0000-0001-9923-8729
FU Swedish Research Council [2016-01381]; Swedish Heart-Lung Foundation
   [20170124, 20180568]; Novo Nordisk [0055026]; EFSD/Lilly European
   Diabetes Research Programme [97012]; Karolinska Institutet, Stockholm,
   Sweden [2-560/2015]; (Gosta Fraenckel Foundation) from the Karolinska
   Institutet, Stockholm, Sweden; Vinnova [2016-01381] Funding Source:
   Vinnova; Swedish Heart-Lung Foundation [20180568, 20180568] Funding
   Source: Swedish Heart-Lung Foundation
FX This work was supported by grants from the Swedish Research Council
   (2016-01381), the Swedish Heart-Lung Foundation (20170124, 20180568),
   Novo Nordisk (2019#0055026), and by EFSD/Lilly European Diabetes
   Research Programme (2018#97012), as well as Research Funds (2-560/2015
   and Gosta Fraenckel Foundation) from the Karolinska Institutet,
   Stockholm, Sweden.
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NR 164
TC 31
Z9 34
U1 0
U2 27
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0925-4439
EI 1879-260X
J9 BBA-MOL BASIS DIS
JI Biochim. Biophys. Acta-Mol. Basis Dis.
PD AUG 1
PY 2020
VL 1866
IS 8
AR 165811
DI 10.1016/j.bbadis.2020.165811
PG 11
WC Biochemistry & Molecular Biology; Biophysics; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Cell Biology
GA MC5AQ
UT WOS:000543299900017
PM 32339643
OA Bronze
DA 2025-06-11
ER

PT J
AU Callcott, ET
   Blanchard, CL
   Snell, P
   Santhakumar, AB
AF Callcott, Esther T.
   Blanchard, Christopher L.
   Snell, Peter
   Santhakumar, Abishek B.
TI The anti-inflammatory and antioxidant effects of acute consumption of
   pigmented rice in humans
SO FOOD & FUNCTION
LA English
DT Article
ID OXIDATIVE STRESS; DIETARY POLYPHENOLS; METABOLIC SYNDROME; BLACK; BRAN;
   RED; SUPPLEMENTATION; INFLAMMATION; OBESITY; MALONDIALDEHYDE
AB The pathogenesis of lifestyle diseases has been significantly correlated to high levels of oxidative stress and pro-inflammation. The antioxidant and anti-inflammatory properties of polyphenols in coloured rice varieties could have potential to neutralize oxidative stress and modulate inflammatory responses. A cross-over design, randomised, dietary intervention human clinical trial was conducted on a pre-screened healthy population (n = 24) investigating the antioxidant and anti-inflammatory potential of pigmented rice (purple, red and brown) varieties. Post baseline blood samples collection volunteers consumed a serve of cooked pigmented rice. Blood samples were collected at 30-minutes, 1, 2 and 4-hours post rice consumption. A one-week wash-out period between each supplementation bout (rice variety) was conducted. Blood and biochemical parameters were analysed on baseline blood samples. Antioxidant activity, malondialdehyde (MDA) and a pro-inflammatory cytokine panel were analysed on the blood samples collected. Post purple rice consumption, antioxidant activity increased (p < 0.0001) by 70.5% and maintained elevated for all time points. The red rice variety Yunlu29, significantly (p < 0.005) reduced MDA levels by 9.2% at the 30-minute time point. Purple rice demonstrated a significant (p < 0.05) decrease by 4.0% at the 30-minute time point only. Purple rice significantly decreased TNF-alpha levels at the 1-hour (p < 0.05) and 4-hour (p < 0.005) time points by 21.9% and 25.4% respectively. IL-6 concentrations were significantly reduced at 1 and 2-hour post Purple (p < 0.05; 11.7%) and Yunlu29 (red) (p < 0.01; 14.1%) consumption respectively. The brown rice variety did not affect any parameters tested. The outcomes of this study, highlight that polyphenols found in pigmented rice may play a key role in targeting specific oxidative stress and inflammatory therapeutic pathways. Pigmented rice varieties may serve as a potential functional food in reducing risk factors associated with lifestyle diseases.
C1 [Callcott, Esther T.; Blanchard, Christopher L.; Santhakumar, Abishek B.] Charles Sturt Univ, Graham Ctr Agr Innovat, Australian Res Council ARC Ind Transformat Traini, Wagga Wagga, NSW 2650, Australia.
   [Callcott, Esther T.; Blanchard, Christopher L.; Santhakumar, Abishek B.] Charles Sturt Univ, Sch Biomed Sci, Wagga Wagga, NSW 2650, Australia.
   [Snell, Peter] Yanco Agr Inst, New South Wales Dept Primary Ind, Private Mail Bag, Yanco, NSW 2703, Australia.
C3 Charles Sturt University; Charles Sturt University; Department of
   Primary Industries & Regional Development NSW
RP Santhakumar, AB (corresponding author), Charles Sturt Univ, Graham Ctr Agr Innovat, Australian Res Council ARC Ind Transformat Traini, Wagga Wagga, NSW 2650, Australia.; Santhakumar, AB (corresponding author), Charles Sturt Univ, Sch Biomed Sci, Wagga Wagga, NSW 2650, Australia.
EM asanthakumar@csu.edu.au
RI Santhakumar, Abishek/B-6700-2017; Callcott, Esther/R-6815-2018;
   Blanchard, Christopher/P-5124-2016
OI Callcott, Esther/0000-0002-1976-4575; Blanchard,
   Christopher/0000-0001-5800-4678
FU Australian Research Council (ARC) Industrial Transformation Centre
   (ITTC) for Functional Grains [IC140100027]; ARC ITTC for Functional
   Grains
FX The authors would like to acknowledge the NSW Department of Primary
   Industries, Rice Research Australia Pty Ltd and SunRice (R). The authors
   would like to provide their sincere thanks to the participants who
   volunteered their time to partake in the study. This project was funded
   by the Australian Research Council (ARC) Industrial Transformation
   Centre (ITTC) for Functional Grains (Project ID: IC140100027). E.
   Callcott is a scholarship recipient of the ARC ITTC for Functional
   Grains.
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PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PD DEC 1
PY 2019
VL 10
IS 12
BP 8230
EP 8239
DI 10.1039/c9fo02455g
PG 10
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA KD1PE
UT WOS:000507643700053
PM 31729520
DA 2025-06-11
ER

PT J
AU Pierce, JL
   Ding, KH
   Xu, JR
   Sharma, AK
   Yu, KL
   Arbona, ND
   Rodríguez-Santos, Z
   Bernard, PJ
   Bollag, WB
   Johnson, MH
   Hamrick, MW
   Begun, DL
   Shi, XM
   Isales, CM
   McGee-Lawrence, ME
AF Pierce, Jessica L.
   Ding, Ke-Hong
   Xu, Jianrui
   Sharma, Anuj K.
   Yu, Kanglun
   Arbona, Natalia del Mazo
   Rodriguez-Santos, Zuleika
   Bernard, Paul J.
   Bollag, Wendy B.
   Johnson, Maribeth H.
   Hamrick, Mark W.
   Begun, Dana L.
   Shi, Xing-Ming
   Isales, Carlos M.
   McGee-Lawrence, Meghan E.
TI The glucocorticoid receptor in osteoprogenitors regulates bone mass and
   marrow fat
SO JOURNAL OF ENDOCRINOLOGY
LA English
DT Article
DE skeleton; marrow adiposity; osteoprogenitor; osteoblast; nutrition;
   metabolic stress; corticosterone; sympathetic tone; beta-adrenergic
ID 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1; MESENCHYMAL STEM-CELLS;
   ACID-PHOSPHATASE 5B; CALORIC RESTRICTION; ADIPOSE-TISSUE;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; TRABECULAR BONE; OSTEOBLASTS;
   MECHANISMS
AB Excess fat within bone marrow is associated with lower bone density. Metabolic stressors such as chronic caloric restriction (CR) can exacerbate marrow adiposity, and increased glucocorticoid signaling and adrenergic signaling are implicated in this phenotype. The current study tested the role of glucocorticoid signaling in CR-induced stress by conditionally deleting the glucocorticoid receptor (Nr3c1; hereafter abbreviated as GR) in bone marrow osteoprogenitors (Osx1-Cre) of mice subjected to CR and ad libitum diets. Conditional knockout of the GR (GR-CKO) reduced cortical and trabecular bone mass as compared to WT mice under both ad libitum feeding and CR conditions. No interaction was detected between genotype and diet, suggesting that the GR is not required for CR-induced skeletal changes. The lower bone mass in GR-CKO mice, and the further decrease in bone by CR, resulted from suppressed bone formation. Interestingly, treatment with the beta-adrenergic receptor antagonist propranolol mildly but selectively improved metrics of cortical bone mass in GR-CKO mice during CR, suggesting interaction between adrenergic and glucocorticoid signaling pathways that affects cortical bone. GR-CKO mice dramatically increased marrow fat under both ad libitum and CR-fed conditions, and surprisingly propranolol treatment was unable to rescue CR-induced marrow fat in either WT or GR-CKO mice. Additionally, serum corticosterone levels were selectively elevated in GR-CKO mice with CR, suggesting the possibility of bone-hypothalamus-pituitary-adrenal crosstalk during metabolic stress. This work highlights the complexities of glucocorticoid and beta-adrenergic signaling in stress-induced changes in bone mass, and the importance of GR function in suppressing marrow adipogenesis while maintaining healthy bone mass.
C1 [Pierce, Jessica L.; Sharma, Anuj K.; Yu, Kanglun; Arbona, Natalia del Mazo; Rodriguez-Santos, Zuleika; Bollag, Wendy B.; Hamrick, Mark W.; McGee-Lawrence, Meghan E.] Augusta Univ, Med Coll Georgia, Dept Cell Biol & Anat, Augusta, GA 30912 USA.
   [Ding, Ke-Hong; Xu, Jianrui; Johnson, Maribeth H.; Shi, Xing-Ming; Isales, Carlos M.] Augusta Univ, Dept Neurosci & Regenerat Med, Augusta, GA USA.
   [Bernard, Paul J.] Pediat Endocrine Specialists Georgia, Duluth, GA USA.
   [Bollag, Wendy B.] Augusta Univ, Dept Physiol, Augusta, GA USA.
   [Bollag, Wendy B.; Hamrick, Mark W.; Isales, Carlos M.; McGee-Lawrence, Meghan E.] Augusta Univ, Dept Orthopaed Surg, Augusta, GA 30912 USA.
   [Bollag, Wendy B.] Charlie Norwood VA Med Ctr, Augusta, GA USA.
   [Begun, Dana L.] Mayo Clin, Dept Orthopaed Surg, Rochester, MN USA.
   [Isales, Carlos M.] Augusta Univ, Dept Med, Div Endocrinol Diabet & Metab, Augusta, GA USA.
C3 University System of Georgia; Augusta University; University System of
   Georgia; Augusta University; University System of Georgia; Augusta
   University; University System of Georgia; Augusta University; US
   Department of Veterans Affairs; Veterans Health Administration (VHA);
   Charlie Norwood VA Medical Center; Mayo Clinic; University System of
   Georgia; Augusta University
RP McGee-Lawrence, ME (corresponding author), Augusta Univ, Med Coll Georgia, Dept Cell Biol & Anat, Augusta, GA 30912 USA.; McGee-Lawrence, ME (corresponding author), Augusta Univ, Dept Orthopaed Surg, Augusta, GA 30912 USA.
EM mmcgeelawrence@augusta.edu
RI Isales, Carlos/ABF-2983-2021; Hamrick, Mark/K-1131-2016; Sharma,
   Anuj/JTS-4887-2023; Isales, Carlos/J-9902-2013
OI Sharma, Anuj/0009-0001-5882-709X; Bollag, Wendy/0000-0003-3146-162X;
   Isales, Carlos/0000-0002-4480-3484
FU National Institutes on Aging [P01-AG036675]; American Diabetes
   Association [1-16-JDF-062]
FX This work was supported by the National Institutes on Aging (grant
   number P01-AG036675; Project 4) and the American Diabetes Association
   (grant number 1-16-JDF-062). The contents do not represent the views of
   the U.S. Department of Veterans Affairs or the United States Government.
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NR 76
TC 20
Z9 22
U1 0
U2 8
PU BIOSCIENTIFICA LTD
PI BRISTOL
PA EURO HOUSE, 22 APEX COURT WOODLANDS, BRADLEY STOKE, BRISTOL BS32 4JT,
   ENGLAND
SN 0022-0795
EI 1479-6805
J9 J ENDOCRINOL
JI J. Endocrinol.
PD OCT
PY 2019
VL 243
IS 1
BP 27
EP 42
DI 10.1530/JOE-19-0230
PG 16
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA IY7BP
UT WOS:000486550300004
PM 31370004
OA Bronze, Green Accepted
DA 2025-06-11
ER

PT J
AU Jian, TY
   Yu, C
   Ding, XQ
   Chen, J
   Li, JW
   Zuo, YY
   Ren, BR
   Lv, H
   Li, WL
AF Jian, Tunyu
   Yu, Chen
   Ding, Xiaoqin
   Chen, Jian
   Li, Jiawei
   Zuo, Yuanyuan
   Ren, Bingru
   Lv, Han
   Li, Weilin
TI Hepatoprotective Effect of Seed Coat of Euryale ferox Extract in
   Non-alcoholic Fatty Liver Disease Induced by High-fat Diet in Mice by
   Increasing IRs-1 and Inhibiting CYP2E1
SO JOURNAL OF OLEO SCIENCE
LA English
DT Article
DE seed coat of Euryale ferox; non-alcoholic fatty liver disease; oxidative
   stress; high-fat diet; IRs-1; CYP2E1
ID CYTOCHROME-P450 2E1 CYP2E1; OXIDATIVE STRESS; INSULIN-RESISTANCE;
   HEPATIC STEATOSIS; ANTIOXIDANT; NAFLD; STEATOHEPATITIS; SALISB.
AB Non-alcoholic fatty liver disease (NAFLD), a common chronic liver disease characterized by hepatic steatosis, affects 30-40% of the population in the world. The seed of Euryale ferox salisb. possesses several pharmacological actions, including metabolic syndrome. However, the seed coat of E. ferox was usually discarded as waste, which contains comparatively abundant polyphenols, and its biological activity has been rarely investigated. In this work, we evaluate the hepatoprotective effect of E. ferox seed coat extract (EFSCE), in NAFLD mice induced by high-fat diet (HFD). The HPLC-MS analysis indicated that the main components of EFSCE were polyphenols. And then, mice were treated with HFD for 4 weeks to induce NAFLD. The result showed that the body weight, weight of adipose tissue, the ratio of liver to body weight in NAFLD mice increased compared with control group. In addition, blood lipids parameters including total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL), low-density lipoprotein cholesterol (LDL) also increased in NAFLD mouse model. It was showed that, after treated with EFSCE (15 and 30 mg/kg/day) for 4 weeks, the body weight, lipids deposition in the liver and blood lipids in HFD-induced NAFLD mice markedly reduced. Compared with NAFLD mice, EFSCE administration could also prevent malondialdehyde (MDA) overproduction and strengthen Superoxide Dismutase (SOD) activity to counteract oxidative stress. Moreover, EFSCE was also found effective in reducing alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activity in HFD-induced NAFLD model, which indicated liver injury in NAFLD. Therefore, EFSCE (rich in polyphenols) is indicated as bioactive nature product for HFD-induced NAFLD treatment, by eliminating lipid accumulation and oxidative stress via regulation of IRs-1 and CYP2E1.
C1 [Jian, Tunyu; Ding, Xiaoqin; Chen, Jian; Li, Jiawei; Zuo, Yuanyuan; Ren, Bingru; Lv, Han; Li, Weilin] Jiangsu Prov & Chinese Acad Sci, Inst Bot, Nanjing 210014, Jiangsu, Peoples R China.
   [Yu, Chen] Nanjing Med Univ, Dept Integrated TCM & Western Med, Jiangsu Canc Hosp, Nanjing 210000, Jiangsu, Peoples R China.
   [Yu, Chen] Nanjing Med Univ, Jiangsu Inst Canc Res, Nanjing 210000, Jiangsu, Peoples R China.
   [Yu, Chen] Nanjing Med Univ, Affiliated Canc Hosp, Nanjing 210000, Jiangsu, Peoples R China.
   [Chen, Jian] Nanjing Forestry Univ, Coll Light Ind & Food Engn, Dept Food Sci & Technol, Nanjing 210037, Jiangsu, Peoples R China.
   [Li, Weilin] Nanjing Forestry Univ, Coll Forestry, Nanjing 210037, Jiangsu, Peoples R China.
C3 Institute of Botany, Jiangsu Province & Chinese Academy of Sciences;
   Nanjing Medical University; Nanjing Medical University; Nanjing Medical
   University; Nanjing Forestry University; Nanjing Forestry University
RP Lv, H; Li, WL (corresponding author), Jiangsu Prov & Chinese Acad Sci, Inst Bot, Nanjing 210014, Jiangsu, Peoples R China.; Li, WL (corresponding author), Nanjing Forestry Univ, Coll Forestry, Nanjing 210037, Jiangsu, Peoples R China.
EM xiaohan1814@163.com; lwlcnbg@cnbg.net
RI li, wenting/P-8707-2019; YANG, LEI/GQH-4271-2022; Jian,
   Tunyu/B-5601-2018
OI Zuo, Yuanyuan/0000-0003-2617-7341; Jian, Tunyu/0000-0002-9814-500X
FU National Natural Science Foundation of China [81703224, 81773885,
   31770366]; Jiangsu Province Science and Technology Modern Agricultural
   Plan [BE2016383]; Jiangsu Key Laboratory for the Research and
   Utilization of Plant Resources [JSPKLB201833]; Jiangsu Service Center
   for Antidiabetic Drugs Screening [BM2011117]
FX This study was supported by the National Natural Science Foundation of
   China(No. 81703224; No. 81773885; No. 31770366), Jiangsu Province
   Science and Technology Modern Agricultural Plan(No. BE2016383), Jiangsu
   Key Laboratory for the Research and Utilization of Plant Resources(No.
   JSPKLB201833) and a grant from Jiangsu Service Center for Antidiabetic
   Drugs Screening (BM2011117). The author would like to thank the help
   from Miss. Fangya Chen.
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NR 24
TC 19
Z9 19
U1 2
U2 26
PU JAPAN OIL CHEMISTS SOC
PI TOKYO
PA YUSHI KOGYO KAIKAN BLDG, 13-11, NIHONBASHI 3-CHOME, CHUO-KU, TOKYO,
   103-0027, JAPAN
SN 1345-8957
EI 1347-3352
J9 J OLEO SCI
JI J. Oleo Sci.
PD JUN
PY 2019
VL 68
IS 6
BP 581
EP 589
DI 10.5650/jos.ess19018
PG 9
WC Chemistry, Applied; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Food Science & Technology
GA IB2SX
UT WOS:000470120100011
PM 31092797
OA gold
DA 2025-06-11
ER

PT J
AU Gentile, CL
   Weir, TL
   Cox-York, KA
   Wei, Y
   Wang, D
   Reese, L
   Moran, G
   Estrada, A
   Mulligan, C
   Pagliassotti, MJ
   Foster, MT
AF Gentile, C. L.
   Weir, T. L.
   Cox-York, K. A.
   Wei, Y.
   Wang, D.
   Reese, L.
   Moran, G.
   Estrada, A.
   Mulligan, C.
   Pagliassotti, M. J.
   Foster, M. T.
TI The role of visceral and subcutaneous adipose tissue fatty acid
   composition in liver pathophysiology associated with NAFLD
SO ADIPOCYTE
LA English
DT Article
DE metabolic syndrome; adipose tissue distribution; saturated fat; fatty
   liver; obesity; dyslipidemia
ID BODY-MASS INDEX; ENDOPLASMIC-RETICULUM STRESS; IMPAIRED
   GLUCOSE-TOLERANCE; INSULIN-RESISTANCE; CARDIOVASCULAR-DISEASE;
   DIABETES-MELLITUS; HEPATIC STEATOSIS; ABDOMINAL FAT; HEART-DISEASE;
   RISK-FACTORS
AB Visceral adiposity is associated with type-2-diabetes, inflammation, dyslipidemia and non-alcoholic fatty liver disease (NAFLD), whereas subcutaneous adiposity is not. We hypothesized that the link between visceral adiposity and liver pathophysiology involves inherent or diet-derived differences between visceral and subcutaneous adipose tissue to store and mobilize saturated fatty acids. The goal of the present study was to characterize the fatty acid composition of adipose tissue triglyceride and portal vein fatty acids in relation to indices of liver dysregulation. For 8 weeks rats had free access to control (CON; 12.9% corn/safflower oil; 3.6 Kcal/g), high saturated fat (SAT; 45.2% cocoa butter; 4.5 Kcal/g) or high polyunsaturated fat (PUFA; 45.2% safflower oil; 4.5 Kcal/g) diets. Outcome measures included glucose tolerance, visceral and subcutaneous adipose tissue triglyceride, liver phospholipids and plasma (portal and systemic) free fatty acid composition, indices of inflammation and endoplasmic reticulum stress in the liver and adipose tissue depots and circulating adipo/cytokines. Hepatic triglycerides were significantly increased in both high fat diet groups compared to control and were significantly higher in PUFA compared to SAT. Although glucose tolerance was not different among diet groups, SAT increased markers of inflammation and ER stress in the liver and both adipose tissue depots. Fatty acid composition did not differ among adipose depots or portal blood in any dietary group. Overall, these data suggest that diets enriched in saturated fatty acids are associated with liver inflammation, ER stress and injury, but that any link between visceral adipose tissue and these liver indices does not involve selective changes to fatty acid composition in this depot or the portal vein.
C1 [Gentile, C. L.; Weir, T. L.; Cox-York, K. A.; Wei, Y.; Wang, D.; Reese, L.; Moran, G.; Estrada, A.; Mulligan, C.; Pagliassotti, M. J.; Foster, M. T.] Colorado State Univ, Dept Food Sci & Human Nutr, Ft Collins, CO 80523 USA.
C3 Colorado State University System; Colorado State University Fort Collins
RP Foster, MT (corresponding author), Colorado State Univ, Dept Food Sci & Human Nutr, Ft Collins, CO 80523 USA.
EM Michelle.Foster@colostate.edu
RI Pagliassotti, Michael/AAV-8238-2021; Estrada, Andrea/HZH-3981-2023
FU National Institutes of Health [DK072017, DK087816]
FX Research reported in this publication was supported by the National
   Institutes of Health under award number DK072017 to Michael Pagliassotti
   and DK087816 to Michelle Foster.
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NR 47
TC 27
Z9 30
U1 0
U2 10
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 2162-3945
EI 2162-397X
J9 ADIPOCYTE
JI Adipocyte
PD APR 3
PY 2015
VL 4
IS 2
BP 101
EP 112
DI 10.4161/21623945.2014.978662
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA CM4MR
UT WOS:000357659300003
PM 26167414
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Ferreira, MJ
   Dias, DD
   Silva, GD
   de Araujo, AA
   Dutra, MRH
   Bernardes, N
   Irigoyen, MC
   De Angelis, K
AF Ferreira, Maycon Junior
   Dias, Danielle da Silva
   Silva, Gabriel do Carmo
   de Araujo, Amanda Aparecida
   Dutra, Marina Rascio Henriques
   Bernardes, Nathalia
   Irigoyen, Maria-Claudia
   De Angelis, Katia
TI Concurrent exercise training potentiates the effects of
   angiotensin-converting enzyme inhibitor on regulatory systems of blood
   pressure control in ovariectomized hypertensive rats
SO JOURNAL OF HYPERTENSION
LA English
DT Article
DE arterial hypertension; baroreflex sensitivity; concurrent exercise
   training; enalapril
ID CARDIOVASCULAR AUTONOMIC CONTROL; OXIDATIVE STRESS; RISK PROFILE;
   METABOLIC SYNDROME; HYDROGEN-PEROXIDE; SKELETAL-MUSCLE; MENOPAUSE;
   ENALAPRIL; AGE; ANTIOXIDANT
AB Objective: Enalapril has shown satisfactory potential in controlling increased and sustained blood pressure (BP). However, multiple dysregulated mechanisms that interact with each other and are involved in the pathophysiology of arterial hypertension may not be affected, contributing to the remaining cardiovascular risk. Using an exercise training protocol, we investigated whether adding both approaches to arterial hypertension management could promote higher modulation of regulatory mechanisms of BP in postmenopausal rats.
   Methods: Spontaneously hypertensive rats were allocated into sedentary (S) and ovariectomized groups: sedentary (OS), sedentary treated with enalapril maleate (OSE) and trained treated with enalapril maleate (OTE). Both the pharmacological and exercise training protocols lasted for 8 weeks. The BP was directly recorded. Inflammation and oxidative stress were evaluated in the cardiac tissue.
   Results: Although BP reduction was similar between OSE and OTE, trained group showed lower vasopressor systems outflow after sympathetic ganglion blocking by hexamethonium (mean BP) (OTE: -53.7 +/- 9.86 vs. OS: -75.7 +/- 19.2 mmHg). Bradycardic and tachycardic response were increased in OTE group (-1.4 +/- 0.4 and -2.6 +/- 0.4 vs. OS: -0.6 +/- 0.3 and -1.3 +/- 0.4 bpm/mmHg, respectively), as well as BP variability. In addition, the combination of approaches induced an increase in interleukin 10, antioxidant defense (catalase and glutathione peroxidase) and nitrite levels compared with the OS group.
   Conclusion: Despite similar BP, the inclusion of exercise training in antihypertensive drug treatment exacerbates the positive adaptations induced by enalapril alone on autonomic, inflammatory and oxidative stress profiles, probably affecting end-organ damage and remaining risk.
C1 [Ferreira, Maycon Junior; Silva, Gabriel do Carmo; de Araujo, Amanda Aparecida; De Angelis, Katia] Univ Fed Sao Paulo UNIFESP, Exercise Physiol Lab, Sao Paulo, SP, Brazil.
   [Dias, Danielle da Silva] Univ Fed Maranhao UFMA, Postgrad Program Phys Educ, Sao Luis, MA, Brazil.
   [Dias, Danielle da Silva; Dutra, Marina Rascio Henriques; De Angelis, Katia] Univ Nove Julho UNINOVE, Translat Physiol Lab, Sao Paulo, Brazil.
   [Bernardes, Nathalia] Univ Sao Judas Tadeu USJT, Human Movement Lab, Sao Paulo, Brazil.
   [Irigoyen, Maria-Claudia] Univ Sao Paulo, Heart Inst InCor, Hypertens Unit, Sao Paulo, SP, Brazil.
   [De Angelis, Katia] Univ Fed Sao Paulo, UNIFESP, BR-04023901 Sao Paulo, SP, Brazil.
C3 Universidade Federal de Sao Paulo (UNIFESP); Universidade Federal do
   Maranhao; Universidade Nove de Julho; Universidade Sao Judas Tadeu;
   Universidade de Sao Paulo; Universidade Federal de Sao Paulo (UNIFESP)
RP De Angelis, K (corresponding author), Univ Fed Sao Paulo, UNIFESP, BR-04023901 Sao Paulo, SP, Brazil.
EM prof.kangelis@yahoo.com.br
RI Ferreira, Maycon/AET-1400-2022; DE ANGELIS, KATIA/I-6098-2016; da Silva
   Dias, Danielle/AAN-7618-2020; IRIGOYEN, MARIA/N-6880-2014
OI Junior Ferreira, Maycon/0000-0001-7198-1908
FU Sao Paulo Research Foundation (FAPESP) [2019/06277-0, 2022/04050-1];
   National Council for Scientific and Technological Development (CNPq)
   [407398/2021-0, 406792/2022-4]; CNPq Fellowship (CNPq-BPQ)
FX Funding was provided by 2019/06277-0, Sao Paulo Research Foundation
   (FAPESP); 2022/04050-1, Sao Paulo Research Foundation (FAPESP);
   407398/2021-0 and 406792/2022-4, National Council for Scientific and
   Technological Development (CNPq). Katia De Angelis and MariaClaudia
   Irigoyen are recipients of CNPq Fellowship (CNPq-BPQ).
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NR 66
TC 2
Z9 2
U1 2
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0263-6352
EI 1473-5598
J9 J HYPERTENS
JI J. Hypertens.
PD APR
PY 2024
VL 42
IS 4
BP 650
EP 661
DI 10.1097/HJH.0000000000003670
PG 12
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA SJ7L8
UT WOS:001234151100003
PM 38441185
DA 2025-06-11
ER

PT J
AU Sanz, RL
   Menéndez, SG
   Inserra, F
   Ferder, L
   Manucha, W
AF Sanz, Raul Lelio
   Menendez, Sebastian Garcia
   Inserra, Felipe
   Ferder, Leon
   Manucha, Walter
TI Cellular and Mitochondrial Pathways Contribute to SGLT2
   Inhibitors-mediated Tissue Protection: Experimental and Clinical Data
SO CURRENT PHARMACEUTICAL DESIGN
LA English
DT Review
DE SGLT2i; cardiovascular diseases; sirtuins; oxidative stress;
   inflammation; mitochondrial dysfunction
ID ANGIOTENSIN-II; MECHANISMS; SIRTUINS; INFLAMMATION; DAMAGE; METABOLISM;
   ACTIVATION; BENEFITS; OBESITY; HEART
AB In metabolic syndrome and diabetes, compromised mitochondrial function emerges as a critical driver of cardiovascular disease, fueling its development and persistence, culminating in cardiac remodeling and adverse events. In this context, angiotensin II - the main interlocutor of the renin-angiotensin-aldosterone system - promotes local and systemic oxidative inflammatory processes. To highlight, the low activity/expression of proteins called sirtuins negatively participates in these processes, allowing more significant oxidative imbalance, which impacts cellular and tissue responses, causing tissue damage, inflammation, and cardiac and vascular remodeling. The reduction in energy production of mitochondria has been widely described as a significant element in all types of metabolic disorders. Additionally, high sirtuin levels and AMPK signaling stimulate hypoxia-inducible factor 1 beta and promote ketonemia. Consequently, enhanced autophagy and mitophagy advance through cardiac cells, sweeping away debris and silencing the orchestra of oxidative stress and inflammation, ultimately protecting vulnerable tissue from damage. To highlight and of particular interest, SGLT2 inhibitors (SGLT2i) profoundly influence all these mechanisms. Randomized clinical trials have evidenced a compelling picture of SGLT2i emerging as game-changers, wielding their power to demonstrably improve cardiac function and slash the rates of cardiovascular and renal events. Furthermore, driven by recent evidence, SGLT2i emerge as cellular supermolecules, exerting their beneficial actions to increase mitochondrial efficiency, alleviate oxidative stress, and curb severe inflammation. Its actions strengthen tissues and create a resilient defense against disease. In conclusion, like a treasure chest brimming with untold riches, the influence of SGLT2i on mitochondrial function holds untold potential for cardiovascular health. Unlocking these secrets, like a map guiding adventurers to hidden riches, promises to pave the way for even more potent therapeutic strategies
C1 [Sanz, Raul Lelio; Menendez, Sebastian Garcia; Manucha, Walter] Consejo Nacl Invest Cient & Tecn, Dept Patol Pharmacol, Inst Med & Biol Expt Cuyo, IMBECU, RA-5500 Mendoza, Argentina.
   [Menendez, Sebastian Garcia; Manucha, Walter] Univ Nacl Cuyo, Fac Ciencias Med, Dept Patol & Pharmacol, Lab Farmacol Expt Bas & Traslac,Area Farmacol, RA-5500 Mendoza, Argentina.
   [Inserra, Felipe; Ferder, Leon] Univ Maimonides, Dept Pathol & Pharmacol, C1405, Buenos Aires, Argentina.
C3 Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET);
   Instituto de Medicina y BiologIa Experimental de Cuyo (IMBECU);
   University Nacional Cuyo Mendoza
RP Manucha, W (corresponding author), Consejo Nacl Invest Cient & Tecn, Dept Patol Pharmacol, Inst Med & Biol Expt Cuyo, IMBECU, RA-5500 Mendoza, Argentina.; Manucha, W (corresponding author), Univ Nacl Cuyo, Fac Ciencias Med, Dept Patol & Pharmacol, Lab Farmacol Expt Bas & Traslac,Area Farmacol, RA-5500 Mendoza, Argentina.
EM wmanucha@yahoo.com.ar
OI Manucha, Walter/0000-0002-2279-7626
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NR 74
TC 6
Z9 6
U1 2
U2 5
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1381-6128
EI 1873-4286
J9 CURR PHARM DESIGN
JI Curr. Pharm. Design
PY 2024
VL 30
IS 13
BP 969
EP 974
DI 10.2174/0113816128289350240320063045
PG 6
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA QN6J3
UT WOS:001221587500001
PM 38551044
DA 2025-06-11
ER

PT J
AU Colletti, A
   Pellizzato, M
   Cicero, AF
   Roy, D
AF Colletti, Alessandro
   Pellizzato, Marzia
   Cicero, Arrigo Francesco
   Roy, Denis
TI The Possible Role of Probiotic Supplementation in Inflammation: A
   Narrative Review
SO MICROORGANISMS
LA English
DT Review
DE probiotics; inflammation; aging; oxidative stress; urinary tract
   infections; cardiovascular disease; gut microbiota
ID URINARY-TRACT-INFECTIONS; LACTOBACILLUS-PLANTARUM 299V;
   TRIMETHYLAMINE-N-OXIDE; GUT MICROBIOTA; BLOOD-PRESSURE; OXIDATIVE
   STRESS; FERMENTED MILK; HEART-FAILURE; DOUBLE-BLIND; VAGINAL
   SUPPOSITORIES
AB The fine balance between symbiotic and potentially opportunistic and/or pathogenic microorganisms can undergo quantitative alterations, which, when associated with low intestinal biodiversity, could be responsible for the development of gut inflammation and the so-called "intestinal dysbiosis". This condition is characterized by the disbalance of a fine synergistic mechanism involving the mucosal barrier, the intestinal neuroendocrine system, and the immune system that results in an acute inflammatory response induced by different causes, including viral or bacterial infections of the digestive tract. More frequently, however, dysbiosis is induced slowly and subtly by subliminal causal factors, resulting in a chronic condition related to different diseases affecting the digestive tract and other organs and apparatuses. Studies on animal models, together with studies on humans, highlight the significant role of the gut microbiota and microbiome in the occurrence of inflammatory conditions such as metabolic syndrome and cardiovascular diseases (CVDs); neurodegenerative, urologic, skin, liver, and kidney pathologies; and premature aging. The blood translocation of bacterial fragments has been found to be one of the processes linked to gut dysbiosis and responsible for the possible occurrence of "metabolic endotoxemia" and systemic inflammation, associated with an increased risk of oxidative stress and related diseases. In this context, supplementation with different probiotic strains has been shown to restore gut eubiosis, especially if administered in long-term treatments. The aim of this review is to describe the anti-inflammatory effects of specific probiotic strains observed in clinical trials and the respective indications, highlighting the differences in efficacy depending on strain, formulation, time and duration of treatment, and dosage used.
C1 [Colletti, Alessandro] Univ Turin, Dept Sci & Drug Technol, I-10124 Turin, Italy.
   [Colletti, Alessandro; Pellizzato, Marzia] Italian Soc Nutraceut Formulators SIFNut, I-31033 Treviso, Italy.
   [Cicero, Arrigo Francesco] Univ Bologna, Dept Med & Surg Sci, I-40126 Bologna, Italy.
   [Cicero, Arrigo Francesco] IRCCS AOUBO, Obstet Unit, I-40138 Bologna, Italy.
C3 University of Turin; University of Bologna; IRCCS Azienda
   Ospedaliero-Universitaria di Bologna
RP Colletti, A (corresponding author), Univ Turin, Dept Sci & Drug Technol, I-10124 Turin, Italy.; Colletti, A (corresponding author), Italian Soc Nutraceut Formulators SIFNut, I-31033 Treviso, Italy.
EM alessandro.colletti@unito.it; arrigo.cicero@unibo.it
RI Cicero, Arrigo/H-8244-2019
OI Cicero, Arrigo Francesco Giuseppe/0000-0002-4367-3884; pellizzato,
   marzia/0000-0001-8086-4885
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NR 134
TC 19
Z9 19
U1 3
U2 11
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-2607
J9 MICROORGANISMS
JI Microorganisms
PD SEP
PY 2023
VL 11
IS 9
AR 2160
DI 10.3390/microorganisms11092160
PG 18
WC Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Microbiology
GA S9MT6
UT WOS:001074341000001
PM 37764004
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Wang, TX
   Yao, WL
   Li, J
   He, QY
   Shao, YF
   Huang, FR
AF Wang, Tongxin
   Yao, Weilei
   Li, Ji
   He, Qiongyu
   Shao, Yafei
   Huang, Feiruo
TI Acetyl-CoA from inflammation-induced fatty acids oxidation promotes
   hepatic malate-aspartate shuttle activity and glycolysis
SO AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
LA English
DT Article
DE acetyl-CoA; fatty acid oxidation; glycolysis; inflammation;
   malate-aspartate shuttle
ID MITOCHONDRIAL PROTEIN ACETYLATION; LIVER-INJURY; METABOLISM; SIRT3;
   CELLS; CHAIN; CYCLE; DYSFUNCTION; UREAGENESIS; INHIBITOR
AB Hepatic metabolic syndrome is associated with inflammation, as inflammation stimulates the reprogramming of nutrient metabolism and hepatic mitochondria-generated acetyl-CoA, but how acetyl-CoA affects the reprogramming of nutrient metabolism, especially glucose and fatty acids, in the condition of inflammation is still unclear. Here, we used an acute inflammation model in which pigs were injected with lipopolysaccharide (LPS) and found that hepatic glycolysis and fatty acid oxidation are both promoted. Acetyl-proteome profiling of LPS-infected pigs liver showed that inflammatory stress exacerbates the acetylation of mitochondrial proteins. Both mitochondrial glutamate oxaloacetate transaminase 2 (GOT2) and malate dehydrogenase 2 (MDH2) were acetylated, and the malate-aspartate shuttle (MAS) activity was stimulated to maintain glycolysis. With the use of C-13-carbon tracing in vitro, acetylCoA was found to be mainly supplied by lipid-derived fatty acid oxidation rather than glucose-derived pyruvate oxidative decarboxylation, while glucose was mainly used for lactate production in response to inflammatory stress. The results of the mitochondrial experiment showed that acetyl-CoA directly increases MDH2 and, in turn, the GOT2 acetylation level affects MAS activity. Treatment with palmitate in primary hepatocytes from LPS-injected pigs increased the hepatic production of acetyl-CoA, pyruvate, and lactate; MAS activity; and hepatic MDH2 and GOT2 hyperacetylation, while the deficiency of long-chain acetyl-CoA dehydrogenase resulted in the stabilization of these parameters. These observations suggest that acetylCoA produced by fatty acid oxidation promotes MAS activity and glycolysis via nonenzymatic acetylation during the inflammatory stress response.
C1 [Wang, Tongxin; Yao, Weilei; Li, Ji; He, Qiongyu; Shao, Yafei; Huang, Feiruo] Huazhong Agr Univ, Coll Anim Sci & Technol, Dept Anim Nutr & Feed Sci, Wuhan 430070, Hubei, Peoples R China.
C3 Huazhong Agricultural University
RP Huang, FR (corresponding author), Huazhong Agr Univ, Coll Anim Sci & Technol, Dept Anim Nutr & Feed Sci, Wuhan 430070, Hubei, Peoples R China.
EM huangfeiruo@mail.hzau.edu.cn
FU National Natural Science Foundation of China [31572409]; National Basic
   Research Program of China [2013CB127304]; National Key Research and
   Development Program [2016YFD0500506]
FX This work was supported by the National Natural Science Foundation of
   China Grant 31572409, National Basic Research Program of China Grant
   2013CB127304, and National Key Research and Development Program Grant
   2016YFD0500506.
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NR 60
TC 38
Z9 44
U1 3
U2 42
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0193-1849
EI 1522-1555
J9 AM J PHYSIOL-ENDOC M
JI Am. J. Physiol.-Endocrinol. Metab.
PD OCT
PY 2018
VL 315
IS 4
BP E496
EP E510
DI 10.1152/ajpendo.00061.2018
PG 15
WC Endocrinology & Metabolism; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Physiology
GA GX3LS
UT WOS:000447626200009
PM 29763372
OA Bronze
DA 2025-06-11
ER

PT J
AU Wang, R
   Yin, FZ
   Qin, CM
   Liu, B
   Ma, CM
   Lu, Q
AF Wang, Rui
   Yin, Fu-Zai
   Qin, Chun-Mei
   Liu, Bo
   Ma, Chun-Ming
   Lu, Qiang
TI One-hour postload plasma glucose levels is associated with the
   production of hydrogen peroxide in abdominal obese men with normal
   glucose tolerance
SO INTERNATIONAL JOURNAL OF DIABETES IN DEVELOPING COUNTRIES
LA English
DT Article
DE Oxidative stress; Abdominal obesity; Postprandial glucose
ID POSTPRANDIAL OXIDATIVE STRESS; ENDOTHELIAL DYSFUNCTION; METABOLIC
   SYNDROME; RISK; MEAL; HYPERGLYCEMIA; PROTEIN; DAMAGE; YOUNG
AB To study the effects of acute hyperglycemia on oxidative stress during an oral glucose tolerance test (OGTT). This case-control study was conducted on 21 abdominal obese men (waist circumference a parts per thousand yen90 cm) and 21 normal-weight men (waist circumference < 90 cm) aged 20 similar to 50 years with normal glucose tolerance (NGT). Cases and controls were matched for age. Blood samples were collected at fasting, 0.5, 1, 2 and 3-h postload, and assayed for glucose, insulin, hydrogen peroxide (H2O2) and malondialdehyde (MDA). On OGTT 0.5, 1 and 2-h plasma glucose values were higher in abdominal obese group than in normal-weight group (P < 0.05). The increase of glycemia during the OGTT was followed by a significant increase of H2O2 at 1-h (P < 0.05 versus baseline), which returned to baseline within 3-h in normal-weight subjects, but failed to do so at 2-h and 3-h in abdominal obese subjects (P < 0.05 versus baseline). MDA remained unchanged during OGTT. 1-h postload plasma glucose was positively correlated with fasting plasma H2O2 (r = 0.428, P = 0.005) and 3-h plasma H2O2 (r = 0.474, P = 0.002) during OGTT. In multiple regression analysis, 1-h postload plasma glucose maintained an independent association with fasting plasma H2O2 (beta = 1.776, P = 0.006) and 3-h plasma H2O2 during OGTT (beta = 2.720, P = 0.001). Hydrogen peroxide was elevated for longer periods of time postload in abdominal obese men. Elevated 1-h postload plasma glucose level is closely related with the change of hydrogen peroxide.
C1 [Wang, Rui; Yin, Fu-Zai; Qin, Chun-Mei; Liu, Bo; Ma, Chun-Ming; Lu, Qiang] Hebei Med Univ, Hosp Qinhuangdao 1, Dept Endocrinol, Qinhuangdao 066000, Hebei Province, Peoples R China.
C3 Hebei Medical University
RP Lu, Q (corresponding author), Hebei Med Univ, Hosp Qinhuangdao 1, Dept Endocrinol, 258 Wenhua Rd, Qinhuangdao 066000, Hebei Province, Peoples R China.
EM luqiangtg@163.com
RI Ma, Chunming/HMD-9613-2023
CR Abdul-Ghani MA, 2008, DIABETES CARE, V31, P1650, DOI 10.2337/dc08-0225
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NR 26
TC 2
Z9 2
U1 0
U2 6
PU SPRINGER INDIA
PI NEW DELHI
PA 7TH FLOOR, VIJAYA BUILDING, 17, BARAKHAMBA ROAD, NEW DELHI, 110 001,
   INDIA
SN 0973-3930
EI 1998-3832
J9 INT J DIABETES DEV C
JI Int. Diabetes Dev. Ctries.
PD MAR
PY 2013
VL 33
IS 1
BP 29
EP 33
DI 10.1007/s13410-012-0105-z
PG 5
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 086UJ
UT WOS:000314712800007
DA 2025-06-11
ER

PT J
AU Luoma, PV
AF Luoma, P. V.
TI Gene-Activation Mechanisms in the Regression of Atherosclerosis,
   Elimination of Diabetes Type 2, and Prevention of Dementia
SO CURRENT MOLECULAR MEDICINE
LA English
DT Review
DE Atherosclerosis; CYP; dementia; diabetes; endoplasmic reticulum; gene
   activation; HDL; LXR
ID HIGH-DENSITY-LIPOPROTEIN; ENDOPLASMIC-RETICULUM STRESS; MEDIATED
   GLUCOSE-METABOLISM; APOLIPOPROTEIN-A-I; ALZHEIMERS-DISEASE; HDL
   CHOLESTEROL; X-RECEPTOR; CARDIOVASCULAR-DISEASE; CHEMICAL CHAPERONES;
   INSULIN SENSITIVITY
AB Atherosclerotic vascular disease, diabetes mellitus (DM) and dementia are major global health problems. Both endogenous and exogenous factors activate genes functioning in biological processes. This review article focuses on gene-activation mechanisms that regress atherosclerosis, eliminate DM type 2 (DM2), and prevent cognitive decline and dementia.
   Gene-activating compounds upregulating functions of liver endoplasmic reticulum (ER) and affecting lipid and protein metabolism, increase ER size through membrane synthesis, and produce an antiatherogenic plasma lipoprotein profile. Numerous gene-activators regress atherosclerosis and reduce the occurrence of atherosclerotic disease. The gene-activators increase glucose disposal rate and insulin sensitivity and, by restoring normal glucose and insulin levels, remove metabolic syndrome and DM2. Patients with DM2 show an improvement of plasma lipoprotein profile and glucose tolerance together with increase in liver phospholipid (PL) and cytochrome (CYP) P450. The gene-activating compounds induce hepatic protein and PL synthesis, and upregulate enzymes including CYPs and glucokinase, nuclear receptors, apolipoproteins and ABC (ATP-binding cassette) transporters. They induce reparation of ER structures and eliminate consequences of ER stress. Healthy living habits activate mechanisms that maintain high levels of HDL and apolipoprotein AI, promote health, and prevent cognitive decline and dementia. Agonists of liver X receptor (LXR) reduce amyloid in brain plaques and improve cognitive performance in mouse models of Alzheimer's disease.
   The gene activation increases the capacity to withstand cellular stress and to repair cellular damage and increases life span. Life free of major health problems and in good cognitive health promotes well-being and living a long and active life.
C1 Univ Helsinki, Inst Biomed, FI-00014 Helsinki, Finland.
C3 University of Helsinki
RP Luoma, PV (corresponding author), Univ Helsinki, Inst Biomed, POB 63, FI-00014 Helsinki, Finland.
EM pauli.luoma@fimnet.fi
FU Academy of Finland; Paavo Nurmi Foundation, Finland
FX The author is grateful for excellent collaboration especially to Eero
   Sotaniemi [dagger], Olavi Pelkonen, Markku Savolainen and Vilho Myllyla
   from the University of Oulu, Finland; Christian Ehnholm from the
   National Institute of Health and Welfare, Helsinki; and Heikki Vapaatalo
   from the University of Helsinki. The studies have been supported by the
   Academy of Finland and the Paavo Nurmi Foundation, Finland.
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NR 102
TC 6
Z9 7
U1 2
U2 11
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1566-5240
EI 1875-5666
J9 CURR MOL MED
JI Curr. Mol. Med.
PD JUL
PY 2011
VL 11
IS 5
BP 391
EP 400
PG 10
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 792QQ
UT WOS:000292764200004
PM 21568932
OA Green Published
DA 2025-06-11
ER

PT J
AU de Carvalho, GB
   Brandao-Lima, PN
   Santos, RKF
   Rocha, VD
   Oliveira, AS
   Santos, BD
   Santos, CB
   Reis, AR
   Maia, CSC
   Silva, AMDE
   Pires, LV
AF de Carvalho, Gabrielli Barbosa
   Brandao-Lima, Paula Nascimento
   Santos, Ramara Kadija Fonseca
   Rocha, Vivianne de Sousa
   Oliveira, Alan Santos
   Santos, Beatriz da Cruz
   Santos, Cynthia Batista
   Reis, Aline Rocha
   Maia, Carla Soraya Costa
   de Oliveira e Silva, Ana Mara
   Pires, Liliane Viana
TI Relationship Between the Single Nucleotide Polymorphism A35C in the
   Cu/Zn-Superoxide Dismutase-1 Gene and Glycemic Control in Individuals
   with Type 2 Diabetes Mellitus
SO BIOLOGICAL TRACE ELEMENT RESEARCH
LA English
DT Article; Early Access
DE Type 2 diabetes mellitus; Single nucleotide polymorphism; Insulin
   resistance; Oxidative stress
ID INSULIN-RESISTANCE; METABOLIC SYNDROME; OXIDATIVE STRESS; ASSOCIATION;
   OBESITY; ZINC; PEROXIDATION; CATALASE; MARKERS; COPPER
AB Hyperglycemia in type 2 diabetes mellitus (T2DM) increases oxidative stress. Furthermore, the presence of the single nucleotide polymorphism A35C (SNP A35C) in Cu/Zn-superoxide dismutase1 (SOD1) gene is closely related to this increase in oxidative stress and the development and progression of T2DM and its complications. This study aimed to evaluate the association between SNP A35C (rs2234694) genotypes and glycemic control in T2DM individuals. A total of 110 individuals were evaluated for anthropometric parameters, body composition, glycemic metabolism markers (fasting serum glucose, %HbA1c, insulin, C-peptide, and HOMA-IR, -%B, -%S), and SOD activity. Individuals were grouped according to SNP A35C genotypes. Variables of interest were assessed according to groups. The T-test for independent samples or the Mann-Whitney U test was used to analyze the differences in continuous variables between groups, and the chi-square test was performed for categorical variables. A binary logistic regression model was constructed, with p < 0.05 considered significant. Overweight was found in 81.8% of individuals with T2DM. Individuals with the AC genotype for SNP A35C had higher levels of fasting serum glucose (p = 0.018) and lower values of HOMA-%B (p = 0.044). The presence of the variant allele was positively associated with higher values of fasting serum glucose (OR: 11.340; 95%IC 1.173-109.649; p = 0.036) and HOMA-IR (OR: 9.987; 95%IC 1.127-88.506; p = 0.039). Individuals with the AC genotype of SNP A35C had poorer glycemic control than individuals with the AA genotype, and the presence of the variant allele was associated with poor glycemic control in T2DM individuals.
C1 [de Carvalho, Gabrielli Barbosa; Santos, Ramara Kadija Fonseca; Santos, Cynthia Batista; Reis, Aline Rocha; de Oliveira e Silva, Ana Mara; Pires, Liliane Viana] Univ Fed Sergipe, Dept Nutr, Nutr Sci Postgrad Program, Marcelo Deda Chagas Ave, S-n-Jardim Rosa Elze, BR-49107230 Sao Cristovao, SE, Brazil.
   [de Carvalho, Gabrielli Barbosa; Brandao-Lima, Paula Nascimento; Santos, Ramara Kadija Fonseca; Santos, Cynthia Batista; Reis, Aline Rocha; Pires, Liliane Viana] Univ Fed Sergipe, Ctr Biol & Hlth Sci, Dept Nutr, Nutr Biochem Lab, Sao Cristovao, SE, Brazil.
   [Brandao-Lima, Paula Nascimento; Oliveira, Alan Santos; de Oliveira e Silva, Ana Mara] Univ Fed Sergipe, Postgrad Program Hlth Sci, Aracaju, SE, Brazil.
   Univ Fed Sergipe, Dept Nutr, Lagarto, SE, Brazil.
   [Maia, Carla Soraya Costa] Univ Estadual Ceara, Dept Nutr, Fortaleza, CE, Brazil.
C3 Universidade Federal de Sergipe; Universidade Federal de Sergipe;
   Universidade Federal de Sergipe; Universidade Federal de Sergipe;
   Universidade Estadual do Ceara
RP Pires, LV (corresponding author), Univ Fed Sergipe, Dept Nutr, Nutr Sci Postgrad Program, Marcelo Deda Chagas Ave, S-n-Jardim Rosa Elze, BR-49107230 Sao Cristovao, SE, Brazil.; Pires, LV (corresponding author), Univ Fed Sergipe, Ctr Biol & Hlth Sci, Dept Nutr, Nutr Biochem Lab, Sao Cristovao, SE, Brazil.
EM lvianapires@gmail.com
RI Maia, Carla Soraya/AHC-5903-2022
FU National Council for Scientific and Technological Development (CNPq)
   [455117/2014-4]; Research and Technological Innovation Support
   Foundation of the State of Sergipe (FAPITEC/SE) [PROMOB-88881
   157882/2017-01, PROEF-88887.157406/2017-00, CAPES-Finance Code 001]
FX This work was supported by the National Council for Scientific and
   Technological Development (CNPq) (Universal Notice - Called MCTIC/CNPq N
   degrees 14/2014, process 455117/2014-4), the Research and Technological
   Innovation Support Foundation of the State of Sergipe (FAPITEC/SE:
   PROMOB-88881 157882/2017-01; and PROEF-88887.157406/2017-00), and the
   Coordination for the Improvement of Higher Education Personnel
   (CAPES-Finance Code 001) for their financial support.
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NR 34
TC 0
Z9 0
U1 0
U2 0
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0163-4984
EI 1559-0720
J9 BIOL TRACE ELEM RES
JI Biol. Trace Elem. Res.
PD 2025 FEB 25
PY 2025
DI 10.1007/s12011-025-04555-8
EA FEB 2025
PG 7
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA Y5I1C
UT WOS:001432447200001
PM 39994114
DA 2025-06-11
ER

PT J
AU Huttl, M
   Markova, I
   Miklankova, D
   Oliyarnyk, O
   Trnovska, J
   Kucera, J
   Sedlacek, R
   Haluzik, M
   Malinska, H
AF Huttl, M.
   Markova, I.
   Miklankova, D.
   Oliyarnyk, O.
   Trnovska, J.
   Kucera, J.
   Sedlacek, R.
   Haluzik, M.
   Malinska, H.
TI METABOLIC CARDIO- AND RENO-PROTECTIVE EFFECTS OF EMPAGLIFLOZIN IN A
   PREDIABETIC RAT MODEL
SO JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
LA English
DT Article
DE empagliflozin; prediabetes; ketone body; insulin sensitivity; oxidative
   stress; neutrophil gelatinase-associated lipocalin; methylglyoxal;
   adiponectin; superoxide dismutase; glutathione peroxidase
ID INHIBITOR EMPAGLIFLOZIN; CARDIOVASCULAR OUTCOMES; OXIDATIVE STRESS;
   HEART-FAILURE; TYPE-2; METHYLGLYOXAL; INFLAMMATION; IMPROVES; URINARY;
   ACID
AB The mechanisms behind the cardiovascular and renal benefits of empagliflozin is not fully understood. The positive impact of the medication on cardiovascular mortality can not be solely attributed to its antidiabetic effect, with a metabolic mechanism possibly involved. To investigate the metabolic effects of empagliflozin treatment (10 mg/kg/day for 6 weeks), we used an adult male rat model with serious vascular complications associated with metabolic syndrome and prediabetes. Impaired glucose tolerance, severe albuminuria and impaired insulin sensitivity were induced by intragastric administration of methylglyoxal and high sucrose diet feeding for four months. Although empagliflozin decreased body weight, non-fasting glucose and insulin, glucagon levels remained unchanged. In addition, empagliflozin increased adiponectin levels (+40%; p < 0.01) and improved skeletal muscle insulin sensitivity. Increased non-esterified fatty acids (NEFA) in empagliflozin-treated rats is understood to generate ketone bodies. Empagliflozin increased beta-hydroxybutyrate levels in serum (+66%; p < 0.05) and the myocardium (30%; p < 0.01), suggesting its possible involvement as an alternative substrate for metabolism. Empagliflozin switched substrate utilisation in the myocardium, diverting glucose oxidation to fatty acid oxidation. Representing another favorable effect, empagliflozin also contributed to decreased uric acid plasma levels (-19%; p < 0.05). In the kidney cortex, empagliflozin improved oxidative and dicarbonyl stress parameters and increased gene expression of beta-hydroxybutyrate dehydrogenase, an enzyme involved in ketone body utilisation. In addition, empagliflozin decreased microalbuminuria (-27%; p < 0.01) and urinary neutrophil gelatinase-associated lipocalin (NGAL) excretion (-29%; p < 0.01). Our results reveal the important systemic metabolic effect of empagliflozin on alterations in substrate utilisation and on increased ketone body use in prediabetic rats. Improved oxidative and dicarbonyl stress and decreased uric acid are also possibly involved in the cardio- and reno-protective effects of empagliflozin.
C1 [Huttl, M.; Markova, I.; Miklankova, D.; Oliyarnyk, O.; Trnovska, J.; Haluzik, M.; Malinska, H.] Inst Clin & Expt Med, Ctr Expt Med, 1958-9 Videnska St, Prague 14021 4, Czech Republic.
   [Kucera, J.; Sedlacek, R.] Czech Acad Sci, Inst Mol Genet, Czech Ctr Phenogen, Vestec, Czech Republic.
C3 Institute for Clinical & Experimental Medicine (IKEM); Czech Academy of
   Sciences; Institute of Molecular Genetics of the Czech Academy of
   Sciences
RP Malinska, H (corresponding author), Inst Clin & Expt Med, Ctr Expt Med, 1958-9 Videnska St, Prague 14021 4, Czech Republic.
EM hana.malinska@ikem.cz
RI Sedlacek, Radislav/G-4408-2014; Oliyarnyk, Olena/Q-6380-2019
OI Trnovska, Jaroslava/0000-0001-6468-8244; Miklankova,
   Denisa/0000-0002-8771-9338; Markova, Irena/0000-0002-4331-7636
FU Czech Science Foundation [19-06199S]; Ministry of Health of the Czech
   Republic - conceptual development of research organisations (Institute
   for Clinical and Experimental Medicine - IKEM) [IN 00023001]
FX Supported by a grant from the Czech Science Foundation: project number
   19-06199S and the Ministry of Health of the Czech Republic - conceptual
   development of research organisations (Institute for Clinical and
   Experimental Medicine -IKEM, IN 00023001).
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NR 56
TC 10
Z9 10
U1 0
U2 10
PU POLISH PHYSIOLOGICAL SOC
PI GRZEGORZECKA
PA JAGIELLONIAN UNIV SCHOOL MED, INST PHYSIOLOGY, 31-531 KRAKOW, 16
   GRZEGORZECKA, POLAND
SN 0867-5910
J9 J PHYSIOL PHARMACOL
JI J. Physiol. Pharmacol.
PD OCT
PY 2020
VL 71
IS 5
DI 10.26402/jpp.2020.5.04
PG 11
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA QA0LA
UT WOS:000613141400002
PM 33475091
DA 2025-06-11
ER

PT J
AU Luppi, P
   Drain, P
AF Luppi, P.
   Drain, P.
TI C-peptide antioxidant adaptive pathways in β cells and diabetes
SO JOURNAL OF INTERNAL MEDICINE
LA English
DT Review
DE diabetes mellitus; inflammation; insulin resistance; metabolic syndrome;
   oxidative stress; reactive oxygen species
ID GLUCOSE-INDUCED APOPTOSIS; INSULIN-PRODUCING CELLS; PANCREATIC-ISLET
   CELLS; ENZYME GENE-EXPRESSION; SMOOTH-MUSCLE-CELLS; FREE FATTY-ACIDS;
   FACTOR-KAPPA-B; OXIDATIVE STRESS; ENDOTHELIAL DYSFUNCTION; MICROVASCULAR
   COMPLICATIONS
AB In this review, we present findings that support autocrine cell protection by C-peptide in the context of clinical studies of type 1 diabetes (T1D), which universally measure C-peptide serum levels as a surrogate for beta cell functional mass. Over the last decade, evidence has accumulated that supports models in which C-peptide, cosecreted with insulin by pancreatic beta cells, acts on peripheral targets including the vascular endothelium to reduce oxidative stress and apoptosis subsequent to exposure to diabetic insults. In parallel, as assays have become more sensitive, C-peptide has been detected in the circulation of most subjects with T1D where higher C-peptide levels are associated with fewer and slower development of diabetic microvascular complications, consistent with antioxidant protection by C-peptide. Clinical trials investigating C-peptide-replacement therapy effects have demonstrated amelioration of T1D nephropathy and neuropathy. Recently, the antioxidant action of C-peptide was extended to the beta cells secreting it, that is an autocrine mechanism. Autocrine protection has major implications for the treatment of diabetes because the more C-peptide secreted, the more protection provided to the same beta cells resulting in a slower decay in beta cell functional mass over the time course of disease. Why beta cells evolved to cosecrete an antioxidant C-peptide hormone together with the glycaemia-lowering insulin hormone is explored in the context of proposed evolutionary advantages of physiologically transient oxidative stress and insulin resistance as an adaptation for survival through times of fuel scarcity. The importance of recognizing autocrine C-peptide protection of functional beta cell mass in observational clinical studies, and its therapeutic implications in interventional C-peptide-replacement studies, will be discussed.
C1 [Luppi, P.; Drain, P.] Univ Pittsburgh, Sch Med, Dept Cell Biol, Room 323,Starzl Biomed Sci Tower South, Pittsburgh, PA 15261 USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE); University
   of Pittsburgh
RP Drain, P (corresponding author), Univ Pittsburgh, Sch Med, Dept Cell Biol, Room 323,Starzl Biomed Sci Tower South, Pittsburgh, PA 15261 USA.
EM drain@pitt.edu
RI Drain, Peter/JCP-0504-2023
FU Pittsburgh Foundation Medical Research Grant [M2009-0041]
FX The authors would like to thank the Department of Cell Biology,
   University of Pittsburgh School of Medicine for outstanding fluorescence
   instrumentation, and Charles S. Peirce for critical advice. The study
   was funded by The Pittsburgh Foundation Medical Research Grant
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NR 103
TC 24
Z9 28
U1 0
U2 12
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0954-6820
EI 1365-2796
J9 J INTERN MED
JI J. Intern. Med.
PD JAN
PY 2017
VL 281
IS 1
BP 7
EP 24
DI 10.1111/joim.12522
PG 18
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA EK5EP
UT WOS:000393950000002
PM 27251308
OA Bronze
DA 2025-06-11
ER

PT J
AU Liu, Q
   Liu, H
   Bai, H
   Huang, W
   Zhang, R
   Tan, J
   Guan, L
   Fan, P
AF Liu, Q.
   Liu, H.
   Bai, H.
   Huang, W.
   Zhang, R.
   Tan, J.
   Guan, L.
   Fan, P.
TI Association of SOD2 A16V and PON2 S311C polymorphisms with polycystic
   ovary syndrome in Chinese women
SO JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
LA English
DT Article
DE Superoxide dismutase 2; Paraoxonase 2; Gene polymorphism; Oxidative
   stress; Polycystic ovary syndrome
ID MANGANESE SUPEROXIDE-DISMUTASE; MNSOD GENE POLYMORPHISM;
   CORONARY-ARTERY-DISEASE; ACTIVATING-FACTOR ACETYLHYDROLASE; OXIDATIVE
   STRESS; PARAOXONASE 1; CLINICAL PHENOTYPES; METABOLIC SYNDROME; SYNDROME
   PCOS; RISK
AB PurposeTo investigate the relationship between superoxide dismutase 2 (SOD2) A16V and paraoxonase 2 (PON2) S311C gene variants and the risk of polycystic ovary syndrome (PCOS) and evaluate the effects of the genotypes on clinical, hormonal, metabolic and oxidative stress indexes in Chinese women.MethodsThis is a cross-sectional study of 932 patients with PCOS and 745 control women. For the clinical and metabolic association study of genotypes, 631 patients and 492 controls were included after excluding the subjects with interferential factors. Genotypes were determined by polymerase chain reaction (PCR) and restriction fragment length polymorphism analysis. Serum total oxidant status, total antioxidant capacity (T-AOC), oxidative stress index and malondialdehyde (MDA) levels, and clinical and metabolic parameters were also analyzed.ResultsThe prevalence of the A allele of SOD2 A16V polymorphism was significantly greater in patients with PCOS than in control subjects. Genotype (AA+AV) remained a significant predictor for PCOS in prognostic models including age, body mass index, insulin resistance index, high-density lipoprotein (HDL), low-density lipoprotein (LDL), and triglycerides (TGs) as covariates. Patients carrying the A allele had significantly higher serum luteinizing hormone (LH) levels, and the ratio of LH to follicle-stimulating hormone compared with patients with the VV genotype. We also showed that patients carrying the C allele of the PON2 S311C polymorphism had lower T-AOC compared with patients carrying the SS genotype. However, no significant differences were observed in the frequencies of the S311C genotypes and alleles of the PON2 gene between PCOS and control groups.ConclusionThe SOD2 A16V, but not PON2 S311C, polymorphism may be one of the genetic determinants for PCOS in Chinese women.
C1 [Liu, Q.; Bai, H.; Zhang, R.; Guan, L.] Sichuan Univ, Lab Genet Dis & Perinatal Med, Key Lab Birth Defects & Related Dis Women & Child, Minist Educ,West China Univ Hosp 2, Chengdu 610041, Sichuan, Peoples R China.
   [Liu, H.; Huang, W.; Tan, J.] Sichuan Univ, Dept Obstet & Gynecol, West China Univ Hosp 2, Chengdu 610041, Sichuan, Peoples R China.
   [Fan, P.] Sichuan Univ, Lab Genet Dis & Perinatal Med, West China Univ Hosp 2, Chengdu 610041, Sichuan, Peoples R China.
C3 Ministry of Education - China; Sichuan University; Sichuan University;
   Sichuan University
RP Fan, P (corresponding author), Sichuan Univ, Lab Genet Dis & Perinatal Med, West China Univ Hosp 2, Chengdu 610041, Sichuan, Peoples R China.
EM fanping15@scu.edu.cn
OI Fan, Ping/0000-0003-1167-5858
FU Chinese National Natural Science Foundation [81370681]; Program for
   Changjiang Scholars and Innovative Research Team in University, Ministry
   of Education [IRT0935]
FX This work was funded by the Chinese National Natural Science Foundation
   (81370681) and the Program for Changjiang Scholars and Innovative
   Research Team in University, Ministry of Education (IRT0935).
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NR 65
TC 20
Z9 23
U1 0
U2 4
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0391-4097
EI 1720-8386
J9 J ENDOCRINOL INVEST
JI J. Endocrinol. Invest.
PD AUG
PY 2019
VL 42
IS 8
BP 909
EP 921
DI 10.1007/s40618-018-0999-5
PG 13
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA IJ5EZ
UT WOS:000475926900005
PM 30607774
DA 2025-06-11
ER

PT J
AU Saygin, M
   Asci, H
   Cankara, FN
   Bayram, D
   Yesilot, S
   Candan, IA
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AF Saygin, M.
   Asci, H.
   Cankara, F. N.
   Bayram, D.
   Yesilot, S.
   Candan, I. A.
   Alp, H. H.
TI The impact of high fructose on cardiovascular system: Role of α-lipoic
   acid
SO HUMAN & EXPERIMENTAL TOXICOLOGY
LA English
DT Article
DE High-fructose corn syrup; endothelial dysfunction; heart toxicity;
   alpha-lipoic acid; oxidative stress
ID URIC-ACID; VASCULAR DYSFUNCTION; ENDOTHELIAL DYSFUNCTION; CORN SYRUP;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; OXIDATIVE STRESS; NITRIC-OXIDE;
   HYPERURICEMIA; RAT
AB The aim of this study was to evaluate the role of alpha-lipoic acid (alpha-LA) on oxidative damage and inflammation that occur in endothelium of aorta and heart while constant consumption of high-fructose corn syrup (HFCS). The rats were randomly divided into three groups with each group containing eight rats. The groups include HFCS, HFCS + alpha-LA treatment, and control. HFCS was given to the rats at a ratio of 30% of F30 corn syrup in drinking water for I 0 weeks. alpha-LA treatment was given to the rats at a dose of 100 mg/kg/day orally for the last 6 weeks. At the end of the experiment, the rats were killed by cervical dislocation. The blood samples were collected for biochemical studies, and the aortic and cardiac tissues were collected for evaluation of oxidant-antioxidant system, tissue bath, and pathological examination. HFCS had increased the levels of malondialdehyde, creatine kinase MB, lactate dehydrogenase, and uric acid and showed significant structural changes in the heart of the rats by histopathology. Those changes were improved by alpha-LA treatment as it was found in this treatment group. Immunohistochemical expressions of tumor necrosis factor cc and inducible nitric oxide synthase were increased in HFCS group, and these receptor levels were decreased by alpha-LA treatment. All the tissue bath studies supported these findings. Chronic consumption of HFCS caused several problems like cardiac and endothelial injury of aorta by hyperuricemia and induced oxidative stress and inflammation. alpha-LA treatment reduced uric acid levels, oxidative stress, and corrected vascular responses. alpha-LA can be added to cardiac drugs due to its cardiovascular protective effects against the cardiovascular diseases.
C1 [Saygin, M.] Suleyman Demirel Univ, Dept Physiol, Fac Med, TR-32200 Isparta, Turkey.
   [Asci, H.; Cankara, F. N.; Yesilot, S.] Suleyman Demirel Univ, Dept Pharmacol, Fac Med, TR-32200 Isparta, Turkey.
   [Bayram, D.; Candan, I. A.] Suleyman Demirel Univ, Dept Histol & Embriol, Fac Med, TR-32200 Isparta, Turkey.
   [Alp, H. H.] Yuzunciyil Univ, Dept Biochem, Fac Med, Van, Turkey.
C3 Suleyman Demirel University; Suleyman Demirel University; Suleyman
   Demirel University; Yuzuncu Yil University
RP Saygin, M (corresponding author), Suleyman Demirel Univ, Dept Physiol, Fac Med, TR-32200 Isparta, Turkey.
EM fizyolog@gmail.com
RI Cankara, Fatma Nihan/GSO-3881-2022; Aşcı, Halil/W-2149-2017; CANDAN,
   İbrahim/AAU-3501-2021; Bayram, Dilek/ABB-9619-2020; Hakan,
   Hamit/U-2671-2018
OI bayram, dilek/0000-0003-3568-2673; alp, hamit hakan/0000-0002-9202-4944
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NR 50
TC 24
Z9 27
U1 0
U2 20
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0960-3271
EI 1477-0903
J9 HUM EXP TOXICOL
JI Hum. Exp. Toxicol.
PD FEB
PY 2016
VL 35
IS 2
BP 194
EP 204
DI 10.1177/0960327115579431
PG 11
WC Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Toxicology
GA DC8EM
UT WOS:000369452700009
PM 25825413
DA 2025-06-11
ER

PT J
AU Liu, JL
   Desjardins, D
   Branicky, R
   Agellon, LB
   Hekimi, S
AF Liu, Ju-Ling
   Desjardins, David
   Branicky, Robyn
   Agellon, Luis B.
   Hekimi, Siegfried
TI Mitochondrial Oxidative Stress Alters a Pathway in Caenorhabditis
   elegans Strongly Resembling That of Bile Acid Biosynthesis and
   Secretion in Vertebrates
SO PLOS GENETICS
LA English
DT Article
ID LIFE-SPAN; CHOLESTEROL; DYSFUNCTION; METABOLISM; TRANSPORT; GENETICS;
   MUTANTS
AB Mammalian bile acids (BAs) are oxidized metabolites of cholesterol whose amphiphilic properties serve in lipid and cholesterol uptake. BAs also act as hormone-like substances that regulate metabolism. The Caenorhabditis elegans clk-1 mutants sustain elevated mitochondrial oxidative stress and display a slow defecation phenotype that is sensitive to the level of dietary cholesterol. We found that: 1) The defecation phenotype of clk-1 mutants is suppressed by mutations in tat-2 identified in a previous unbiased screen for suppressors of clk-1. TAT-2 is homologous to ATP8B1, a flippase required for normal BA secretion in mammals. 2) The phenotype is suppressed by cholestyramine, a resin that binds BAs. 3) The phenotype is suppressed by the knock-down of C. elegans homologues of BA-biosynthetic enzymes. 4) The phenotype is enhanced by treatment with BAs. 5) Lipid extracts from C. elegans contain an activity that mimics the effect of BAs on clk-1, and the activity is more abundant in clk-1 extracts. 6) clk-1 and clk-1; tat-2 double mutants show altered cholesterol content. 7) The clk-1 phenotype is enhanced by high dietary cholesterol and this requires TAT-2. 8) Suppression of clk-1 by tat-2 is rescued by BAs, and this requires dietary cholesterol. 9) The clk-1 phenotype, including the level of activity in lipid extracts, is suppressed by antioxidants and enhanced by depletion of mitochondrial superoxide dismutases. These observations suggest that C. elegans synthesizes and secretes molecules with properties and functions resembling those of BAs. These molecules act in cholesterol uptake, and their level of synthesis is up-regulated by mitochondrial oxidative stress. Future investigations should reveal whether these molecules are in fact BAs, which would suggest the unexplored possibility that the elevated oxidative stress that characterizes the metabolic syndrome might participate in disease processes by affecting the regulation of metabolism by BAs.
C1 [Liu, Ju-Ling; Desjardins, David; Branicky, Robyn; Hekimi, Siegfried] McGill Univ, Dept Biol, Montreal, PQ H3A 1B1, Canada.
   [Agellon, Luis B.] McGill Univ, Sch Dietet & Human Nutr, Ste Anne De Bellevue, PQ, Canada.
C3 McGill University; McGill University
RP Liu, JL (corresponding author), McGill Univ, Dept Biol, 1205 Doctor Penfield Ave, Montreal, PQ H3A 1B1, Canada.
EM Siegfried.Hekimi@McGill.ca
FU Canadian Institutes of Health Research [MOP-89761]
FX The work was supported by a grant (MOP-89761) from the Canadian
   Institutes of Health Research to SH. SH is the Robert Archibald and
   Catherine Louise Campbell Chair in Developmental Biology. The funders
   had no role in study design, data collection and analysis, decision to
   publish, or preparation of the manuscript.
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NR 42
TC 12
Z9 15
U1 1
U2 12
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1553-7404
J9 PLOS GENET
JI PLoS Genet.
PD MAR
PY 2012
VL 8
IS 3
AR e1002553
DI 10.1371/journal.pgen.1002553
PG 16
WC Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Genetics & Heredity
GA 918MV
UT WOS:000302254800029
PM 22438816
OA Green Submitted, gold, Green Published
DA 2025-06-11
ER

PT J
AU Maranhao, PA
   Kraemer-Aguiar, LG
   de Oliveira, CL
   Kuschnir, MCC
   Vieira, YR
   Souza, MGC
   Koury, JC
   Bouskela, E
AF Maranhao, Priscila A.
   Kraemer-Aguiar, Luiz G.
   de Oliveira, Cecilia L.
   Kuschnir, Maria C. C.
   Vieira, Yasmine R.
   Souza, Maria G. C.
   Koury, Josely C.
   Bouskela, Eliete
TI Brazil nuts intake improves lipid profile, oxidative stress and
   microvascular function in obese adolescents: a randomized controlled
   trial
SO NUTRITION & METABOLISM
LA English
DT Article
DE microcirculation; obesity; Brazil nuts; adolescents; oxidative stress;
   lipid profile
ID REACTIVE HYPEREMIA; WAIST CIRCUMFERENCE; METABOLIC SYNDROME; SKIN;
   PLASMA; WOMEN; SELENIUM; INSULIN; DISEASE; MICROVESSELS
AB Background: Obesity is a chronic disease associated to an inflammatory process resulting in oxidative stress that leads to morpho-functional microvascular damage that could be improved by some dietary interventions. In this study, the intake of Brazil nuts (Bertholletia excelsa), composed of bioactive substances like selenium, alpha-e gamma-tocopherol, folate and polyunsaturated fatty acids, have been investigated on antioxidant capacity, lipid and metabolic profiles and nutritive skin microcirculation in obese adolescents.
   Methods: Obese female adolescents (n = 17), 15.4 +/- 2.0 years and BMI of 35.6 +/- 3.3 kg/m(2), were randomized 1: 1 in two groups with the diet supplemented either with Brazil nuts [BNG, n = 08, 15-25 g/day (equivalent to 3 to 5 units/day)] or placebo [PG (lactose), n = 09, one capsule/day] and followed for 16 weeks. Anthropometry, metabolic-lipid profiles, oxidative stress and morphological (capillary diameters) and functional [functional capillary density, red blood cell velocity (RBCV) at baseline and peak (RBCVmax) and time (TRBCVmax) to reach it during post-occlusive reactive hyperemia, after 1 min arterial occlusion] microvascular variables were assessed by nailfold videocapillaroscopy at baseline (T0) and after intervention (T1).
   Results: T0 characteristics were similar between groups. At T1, BNG (intra-group variation) had increased selenium levels (p = 0.02), RBCV (p = 0.03) and RBCVmax (p = 0.03) and reduced total (TC) (p = 0.02) and LDL-cholesterol (p = 0.02). Compared to PG, Brazil nuts intake reduced TC (p = 0.003), triglycerides (p = 0.05) and LDL-ox (p = 0.02) and increased RBCV (p = 0.03).
   Conclusion: Brazil nuts intake improved the lipid profile and microvascular function in obese adolescents, possibly due to its high level of unsaturated fatty acids and bioactive substances.
C1 [Kraemer-Aguiar, Luiz G.] Clin & Expt Res Lab Vasc Biol BioVasc, Dept Internal Med, BR-20550013 Rio De Janeiro, Brazil.
   [de Oliveira, Cecilia L.] Inst Nutr, Nutr Appl Dept, BR-20550013 Rio De Janeiro, Brazil.
   [Kuschnir, Maria C. C.] NESA, Study Ctr Adolescent Hlth, BR-20551030 Rio De Janeiro, Brazil.
   [Souza, Maria G. C.] Clin & Expt Res Lab Vasc Biol BioVasc, Dept Physiol Sci, BR-20551030 Rio De Janeiro, Brazil.
   [Koury, Josely C.] Inst Nutr, Study Ctr Nutr & Oxidat Stress, BR-20550013 Rio De Janeiro, Brazil.
   [Bouskela, Eliete] Clin & Expt Res Lab Vasc Biol BioVasc, Physiol Sci & Clin Med Dept, BR-20550013 Rio De Janeiro, Brazil.
RP Kraemer-Aguiar, LG (corresponding author), Clin & Expt Res Lab Vasc Biol BioVasc, Dept Internal Med, Rua Sao Francisco Xavier 524, BR-20550013 Rio De Janeiro, Brazil.
EM gkraemer@ig.com.br
RI Koury, Josely/G-8927-2016; Kraemer-Aguiar, Luiz Guilherme/ABG-2833-2022;
   Maranhão, Priscila/F-2624-2013
OI Kraemer-Aguiar, Luiz Guilherme/0000-0002-3528-5881; Maranhao,
   Priscila/0000-0002-4804-4999
FU National Research Council (CNPq); Foundation to Support Research in the
   State of Rio de Janeiro (FAPERJ); Agency to Finance Studies and Projects
   (FINEP); Coordination to Improve Graduate Personnel (CAPES)
FX Authors would like to thank Drs. Tatiane Bertoni de Toledo and Fabiana
   Barreto Lima for their help in recruiting patients and EMBRAPA for
   selenium measurements and Funding: National Research Council (CNPq),
   Foundation to Support Research in the State of Rio de Janeiro (FAPERJ)
   and Agency to Finance Studies and Projects (FINEP). During this study
   Ms. Priscila Maranhao received a fellowship from the Coordination to
   Improve Graduate Personnel (CAPES).
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NR 39
TC 68
Z9 73
U1 0
U2 25
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1743-7075
J9 NUTR METAB
JI Nutr. Metab.
PD MAY 28
PY 2011
VL 8
AR 32
DI 10.1186/1743-7075-8-32
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 785BI
UT WOS:000292202000001
PM 21619692
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Maiti, R
   Agrawal, NK
   Dash, D
   Pandey, BL
AF Maiti, Rituparna
   Agrawal, N. K.
   Dash, D.
   Pandey, B. L.
TI Effect of Pentoxifylline on inflammatory burden, oxidative stress and
   platelet aggregability in hypertensive type 2 diabetes mellitus patients
SO VASCULAR PHARMACOLOGY
LA English
DT Article
DE atherosclerosis; inflammation; type 2 diabetes mellitus; Pentoxifylline
ID C-REACTIVE PROTEIN; TUMOR-NECROSIS-FACTOR; GLYCATION END-PRODUCTS;
   CORONARY-HEART-DISEASE; BLOOD-CELL COUNT; CARDIOVASCULAR-DISEASE;
   ATHEROSCLEROSIS RISK; METABOLIC SYNDROME; GLYCEMIC CONTROL; LEUKOCYTE
   COUNT
AB Objectives: Inflammation and oxidative stress are main culprits behind atherosclerosis in diabetes mellitus. This study explores the effect of addon Pentoxifylline on inflammatory burden and oxidative stress in hypertensive diabetic patients.
   Research design and methods: 60 hypertensive type 2 diabetic, aged ! 45 years were evaluated for anthropometry, clinical parameters, C-reactive protein, total leukocyte count, erythrocyte sedimentation rate, serum albumin, plasma malondialdehyde, blood reduced glutathione, platelet aggregation and clot retraction profile.
   With informed consent and randomization, Pentoxifylline (400 mg) was prescribed to 30 patients orally twice daily with meals as add-on therapy to the standard therapeutic regimen for one month. The particular parameters were repeated in 26 patients in control group and 25 patients in Pentoxitylline group who completed the follow up. The study was a randomized, open, add-on clinical trial with parallel controls. Results: At one-month follow-up, in the Pentoxifylline group, there was 20.9% decrease (p < 0.001) in C-reactive protein, 18% reduction (p < 0.001) in erythrocyte sedimentation rate, 11.1% reduction (p < 0.001) in total leukocyte count and 5.8% increase (p = 0.003) in serum albumin. Pentoxifylline showed 20.2% reduction in plasma malondialdehyde and 4.6% increase in blood reduced glutathione level.
   In therapeutic dose range, Pentoxitylline exerted a significant anti-aggregatory effect and a dose dependent decrease in clot retraction in-vitro but there was no significant change in ex-vivo clot retraction. The control group showed no statistically significant change in parameters assessed.
   Conclusion: This study reveals improvements in inflammatory markers, oxidative stress and platelet-aggregation by Pentoxifylline, thus preventing atherosclerosis in diabetes mellitus. (C) 2007 Elsevier Inc. All rights reserved.
C1 Banaras Hindu Univ, Inst Med Sci, Dept Endocrinol & Metab, Varanasi 221005, Uttar Pradesh, India.
   Banaras Hindu Univ, Inst Med Sci, Dept Pharmacol, Varanasi 221005, Uttar Pradesh, India.
   Banaras Hindu Univ, Inst Med Sci, Dept Biochem, Varanasi 221005, Uttar Pradesh, India.
C3 Banaras Hindu University (BHU); Banaras Hindu University (BHU); Banaras
   Hindu University (BHU)
RP Agrawal, NK (corresponding author), Banaras Hindu Univ, Inst Med Sci, Dept Endocrinol & Metab, Varanasi 221005, Uttar Pradesh, India.
EM rituparnamaiti@rediffmail.com; drnkavns@gmail.com; drnkavns@gmail.com;
   drnkavns@rediffmail.com
RI MAITI, RITUPARNA/MFI-2945-2025; DASH, DEBABRATA/AAF-1837-2020; Agrawal,
   NK/H-8653-2013
OI Agrawal, NK/0000-0001-7322-4134; MAITI, RITUPARNA/0000-0003-4063-9178;
   DASH, DEBABRATA/0009-0008-3595-8928
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NR 70
TC 38
Z9 39
U1 0
U2 6
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1537-1891
EI 1879-3649
J9 VASC PHARMACOL
JI Vasc. Pharmacol.
PD AUG-SEP
PY 2007
VL 47
IS 2-3
BP 118
EP 124
DI 10.1016/j.vph.2007.05.004
PG 7
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 206GY
UT WOS:000249173100006
PM 17613279
DA 2025-06-11
ER

PT J
AU Kumar, KA
   Lalitha, A
   Pavithra, D
   Padmavathi, IJN
   Ganeshan, M
   Rao, KR
   Venu, L
   Balakrishna, N
   Shanker, NH
   Reddy, SU
   Chandak, GR
   Sengupta, S
   Raghunath, M
AF Kumar, Kalle Anand
   Lalitha, Anumula
   Pavithra, Dhandapani
   Padmavathi, Inagadapa J. N.
   Ganeshan, Manisha
   Rao, Kalashikam Rajender
   Venu, Lagishetty
   Balakrishna, Nagala
   Shanker, Nemani Hari
   Reddy, Singi Umakar
   Chandak, Giriraj Ratan
   Sengupta, Shantanu
   Raghunath, Manchala
TI Maternal dietary folate and/or vitamin B12 restrictions alter
   body composition (adiposity) and lipid metabolism in Wistar rat
   offspring
SO JOURNAL OF NUTRITIONAL BIOCHEMISTRY
LA English
DT Article
DE Vitamin restriction; Body composition; Insulin resistance; Lipid
   profile; Adipocytokines
ID INSULIN-RESISTANCE SYNDROME; ADIPOCYTE DIFFERENTIATION; MAGNESIUM
   RESTRICTION; GLUCOSE-INTOLERANCE; GENE-EXPRESSION; BIRTH-WEIGHT;
   FAT-CELLS; TNF-ALPHA; OBESITY; DEFICIENCY
AB Maternal vitamin deficiencies are associated with low birth weight and increased perinatal morbidity and mortality. We hypothesize that maternal folate and/or vitamin B-12 restrictions alter body composition and fat metabolism in the offspring. Female weaning Wistar rats received ad libitum for 12 weeks a control diet (American Institute of Nutrition-76A) or the same with restriction of folate, vitamin B-12 or both (dual deficient) and, after confirming vitamin deficiency, were mated with control males. The pregnant/lactating mothers and their offspring received their respective diets throughout Biochemical and body composition parameters were determined in mothers before mating and in offspring at 3, 6, 9 and 12 months of age. Vitamin restriction increased body weight and fat and altered lipid profile in female Wistar rats, albeit differences were significant with only B-12 restriction. Offspring born to vitamin-B-12-restricted dams had lower birth weight, while offspring of all vitamin-restricted dams weighed higher at/from weaning. They had higher body fat (specially visceral fat) from 3 months and were dyslipidemic at 12 months, when they had high circulating and adipose tissue levels of tumor necrosis factor a, leptin and interleukin 6 and low levels of adiponectin and interleukin 1 beta. Vitamin-restricted offspring had higher activities of hepatic fatty acid synthase and acetyl-CoA-carboxylase and higher plasma cortisol levels. In conclusion, maternal and pen-/postnatal folate and/or vitamin B-12 restriction increased visceral adiposity (due to increased corticosteroid stress), altered lipid metabolism in rat offspring perhaps by modulating adipocyte function and may thus predispose them to high morbidity later. (c) 2013 Elsevier Inc. All rights reserved.
C1 [Kumar, Kalle Anand; Lalitha, Anumula; Padmavathi, Inagadapa J. N.; Ganeshan, Manisha; Rao, Kalashikam Rajender; Venu, Lagishetty; Raghunath, Manchala] ICMR, Div Endocrinol & Metab, Natl Inst Nutr, Hyderabad 500604, Andhra Pradesh, India.
   [Pavithra, Dhandapani; Reddy, Singi Umakar; Chandak, Giriraj Ratan] CSIR, CCMB, Hyderabad 500007, Andhra Pradesh, India.
   [Balakrishna, Nagala] ICMR, Div Stat, Natl Inst Nutr, Hyderabad 500604, Andhra Pradesh, India.
   [Shanker, Nemani Hari] ICMR, Natl Ctr Lab Anim Sci, Natl Inst Nutr, Hyderabad 500604, Andhra Pradesh, India.
   [Sengupta, Shantanu] CSIR, Inst Genom & Integrat Biol, Delhi 110007, India.
C3 Indian Council of Medical Research (ICMR); ICMR - National Institute of
   Nutrition (NIN); Council of Scientific & Industrial Research (CSIR) -
   India; CSIR - Centre for Cellular & Molecular Biology (CCMB); Indian
   Council of Medical Research (ICMR); ICMR - National Institute of
   Nutrition (NIN); Indian Council of Medical Research (ICMR); ICMR -
   National Animal Resource Facility for Biomedical Research (NARFBR); ICMR
   - National Institute of Nutrition (NIN); Council of Scientific &
   Industrial Research (CSIR) - India; CSIR - Institute of Genomics &
   Integrative Biology (IGIB)
RP Raghunath, M (corresponding author), ICMR, Div Endocrinol & Metab, Natl Inst Nutr, Hyderabad 500604, Andhra Pradesh, India.
EM mraghunath55@yahoo.com
RI Padmavathi, Inagadapa/AAX-4745-2020; Nagalla, Balakrishna/GRR-4393-2022;
   Lagishetty, Venu/C-8251-2009
OI Nagalla, Balakrishna/0000-0002-5613-0942; Chandak, Giriraj
   Ratan/0000-0002-3095-9453; Lagishetty, Venu/0000-0001-6500-8255
FU Department of Biotechnology, Government of India, New Delhi, India
   [BT/PR-7506/PID/20/294/2006]; Indian Council of Medical Research (ICMR),
   India
FX This work was supported by a research grant (Project #
   BT/PR-7506/PID/20/294/2006) to M.R., G.R.C. and S.S. from the Department
   of Biotechnology, Government of India, New Delhi, India. The authors
   acknowledge the support and encouragement received from the Directors of
   National Institute of Nutrition and the Centre for Cellular and
   Molecular Biology, Hyderabad, in the conduct of these studies. They also
   thank Dr. M.J. Mahesh Kumar for his help in the conduct of the animal
   experiments at CCMB. Kalle Anand Kumar is grateful to the Indian Council
   of Medical Research (ICMR), India, for awarding senior research
   fellowship.
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NR 48
TC 91
Z9 98
U1 1
U2 23
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0955-2863
J9 J NUTR BIOCHEM
JI J. Nutr. Biochem.
PD JAN
PY 2013
VL 24
IS 1
BP 25
EP 31
DI 10.1016/j.jnutbio.2012.01.004
PG 7
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA 056HT
UT WOS:000312479700004
PM 22703962
DA 2025-06-11
ER

PT J
AU Legro, RS
   Castracane, VD
   Kauffman, RP
AF Legro, RS
   Castracane, VD
   Kauffman, RP
TI Detecting insulin resistance in polycystic ovary syndrome: Purposes and
   pitfalls
SO OBSTETRICAL & GYNECOLOGICAL SURVEY
LA English
DT Article
ID IMPAIRED GLUCOSE-TOLERANCE; BETA-CELL FUNCTION; HORMONE-BINDING
   GLOBULIN; SENSITIVITY CHECK INDEX; FASTING GLUCOSE; OBESE WOMEN;
   CARDIOVASCULAR-DISEASE; ENDOTHELIN-1 LEVELS; ADIPONECTIN LEVELS;
   DIABETES-MELLITUS
AB Approximately 50% to 70% of all women with polycystic ovary syndrome (PCOS) have some degree of insulin resistance, and this hormone insensitivity probably contributes to the hyperandrogenism that is responsible for the signs and symptoms of PCOS. Although uncertainty exists, early detection and treatment of insulin resistance in this population could ultimately reduce the incidence or severity of diabetes mellitus, dyslipidemia, hypertension, and cardiovascular disease. Even if that proves to be the case, there are still several problems with our current approach to insulin sensitivity assessment in PCOS, including the apparent lack of consensus on what defines PCOS and "normal" insulin sensitivity, ethnic and genetic variability, the presence of other factors contributing to insulin resistance such as obesity, stress, and aging, and concern about whether simplified models of insulin sensitivity have the precision to predict treatment needs, responses, and future morbidity. Although the hyperinsulinemic-euglycemic clamp technique is the gold standard for measuring insulin sensitivity, it is too expensive, time-consuming, and labor-intensive to be of practical use in an office setting. Homeostatic measurements (fasting glucose/insulin ratio or homeostatic model assessment [HOMA] value) and minimal model tests (particularly the oral glucose tolerance test [OGTT]) represent the easiest office-based assessments of insulin resistance in the PCOS patient The OGTT is probably the best simple, office-based method to assess women with PCOS because it provides information about both insulin resistance and glucose intolerance. The diagnosis of glucose intolerance holds greater prognostic and treatment implications. All obese women with PCOS should be screened for the presence of insulin resistance by looking for other stigmata of the insulin resistance syndrome such as hypertension, dyslipidemia, central obesity, and glucose intolerance.
C1 Penn State Univ, Milton S Hershey Med Ctr, Coll Med, Dept Obstet & Gynecol, Hershey, PA 17033 USA.
   Texas Tech Univ, Sch Med, Dept Obstet & Gynecol, Amarillo, TX USA.
   Diagnost Syst Labs, Webster, TX USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE);
   Pennsylvania State University; Penn State Health; Texas Tech University
   System; Texas Tech University
RP Penn State Univ, Milton S Hershey Med Ctr, Coll Med, Dept Obstet & Gynecol, 500 Univ Dr, Hershey, PA 17033 USA.
EM RSL1@psu.edu
OI Legro, Richard/0000-0001-9927-7584
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NR 90
TC 317
Z9 359
U1 0
U2 13
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0029-7828
EI 1533-9866
J9 OBSTET GYNECOL SURV
JI Obstet. Gynecol. Surv.
PD FEB
PY 2004
VL 59
IS 2
BP 141
EP 154
DI 10.1097/01.OGX.0000109523.25076.E2
PG 14
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA 767VK
UT WOS:000188494400006
PM 14752302
DA 2025-06-11
ER

PT J
AU Swetha, P
   Velraj, M
AF Swetha, Putta
   Velraj, Malarkodi
TI Type 2 Diabetes mellitus: Current prevalence and future forecast
SO ANNALS OF PHYTOMEDICINE-AN INTERNATIONAL JOURNAL
LA English
DT Review
DE Diabetes mellitus; Metabolic disorder; Insulin; Pancreas; Herbal
   formulation
AB It has been determined that diabetes mellitus is one of the four most significant non-communicable illnesses, and as such, it requires immediate attention from all of the key stakeholders throughout the world in an effort to reduce its prevalence and the difficulties that are connected with it. In light of the consequences of hyperglycemia, as well as hyperglycemic-induced oxidative stress and inflammation, it is regarded to be one of the top 10 major causes of mortality throughout the world, and it is responsible for the deaths of around 1.6 million people each and every year. Additionally, it is regarded as the third most significant risk factor for the premature death of people throughout the world. There is a significant connection between hyperglycemia, hyperglycemic-induced oxidative stress, inflammation, and the onset and progression of type 2 diabetes mellitus. Reports from a variety of sources have demonstrated that persistent low-grade inflammation is connected to an increased chance of developing type 2 diabetes, and that sub-clinical inflammation is a contributor to insulin resistance and is linked to the hallmarks of metabolic syndrome, which include hyperglycemia. Both of these findings are consistent with one another. The fundamental impetus behind the objective of this review was the relationship that exists between diabetes, oxidative stress, and inflammation. By conducting large number of research work, numerous traditional medicines have been found for diabetes. Extracts isolated from different natural resources especially plants, have always been a rich arsenal for controlling and treating diabetes problem and complication arising due to it. Therefore, the reader is able to have a better understanding of the significance of the many different herbal and polyherbal formulations that have historically been used to treat diabetes mellitus as a result of reviewing this article.
C1 [Swetha, Putta] VISTAS, Sch Pharmaceut Sci, Dept Pharmacol, Chennai 600117, Tamil Nadu, India.
   [Velraj, Malarkodi] VISTAS, Sch Pharmaceut Sci, Dept Pharmacognosy, Chennai 600117, Tamil Nadu, India.
C3 Vels Institute of Science, Technology & Advanced Studies; Vels Institute
   of Science, Technology & Advanced Studies
RP Velraj, M (corresponding author), VISTAS, Sch Pharmaceut Sci, Dept Pharmacognosy, Chennai 600117, Tamil Nadu, India.
EM malarkodiv.sps@velsuniv.ac.in
RI Velraj, Malarkodi/AAC-4365-2022
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NR 29
TC 5
Z9 5
U1 1
U2 2
PU UKAAZ PUBLICATIONS
PI HYDERABAD
PA 16-11-511/D/408, SHALIVAHANA NAGAR, MOOSARAMBAGH, HYDERABAD, 500036,
   INDIA
SN 2393-9885
EI 2278-9839
J9 ANN PHYTOMEDICINE
JI Ann. Phytomedicine
PD JUL-DEC
PY 2023
VL 12
IS 2
BP 141
EP 148
DI 10.54085/ap.2023.12.2.16
PG 8
WC Pharmacology & Pharmacy
WE Emerging Sources Citation Index (ESCI)
SC Pharmacology & Pharmacy
GA HS2A7
UT WOS:001161417700016
OA gold
DA 2025-06-11
ER

PT J
AU Marón, FJM
   Ferder, L
   Reiter, RJ
   Manucha, W
AF Mocayar Maron, Feres Jose
   Ferder, Leon
   Reiter, Russel J.
   Manucha, Walter
TI Daily and seasonal mitochondrial protection: Unraveling common possible
   mechanisms involving vitamin D and melatonin
SO JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
LA English
DT Review
DE Vitamin D; VDR; Melatonin; Light/dark cycle; Mitochondria; Oxidative
   stress
ID ISCHEMIA-REPERFUSION INJURY; RENIN-ANGIOTENSIN SYSTEM; KAPPA-B
   ACTIVATION; D-RECEPTOR; OXIDATIVE STRESS; MULTIPLE-SCLEROSIS; D
   DEFICIENCY; 1,25-DIHYDROXYVITAMIN D-3; KLOTHO GENE; D SUPPLEMENTATION
AB From an evolutionary point of view, vitamin D and melatonin appeared very early and share functions related to defense mechanisms. In the current clinical setting, vitamin D is exclusively associated with phosphocalcic metabolism. Meanwhile, melatonin has chronobiological effects and influences the sleep-wake cycle. Scientific evidence, however, has identified new actions of both molecules in different physiological and pathological settings. The biosynthetic pathways of vitamin D and melatonin are inversely related relative to sun exposure. A deficiency of these molecules has been associated with the pathogenesis of cardiovascular diseases, including arterial hypertension, neurodegenerative diseases, sleep disorders, kidney diseases, cancer, psychiatric disorders, bone diseases, metabolic syndrome, and diabetes, among others. During aging, the intake and cutaneous synthesis of vitamin D, as well as the endogenous synthesis of melatonin are remarkably depleted, therefore, producing a state characterized by an increase of oxidative stress, inflammation, and mitochondrial dysfunction. Both molecules are involved in the homeostatic functioning of the mitochondria. Given the presence of specific receptors in the organelle, the antagonism of the renin-angiotensin-aldosterone system (RAAS), the decrease of reactive species of oxygen (ROS), in conjunction with modifications in autophagy and apoptosis, anti-inflammatory properties inter alia, mitochondria emerge as the final common target for melatonin and vitamin D. The primary purpose of this review is to elucidate the common molecular mechanisms by which vitamin D and melatonin might share a synergistic effect in the protection of proper mitochondrial functioning.
C1 [Mocayar Maron, Feres Jose; Manucha, Walter] Univ Nacl Cuyo, Fac Ciencias Med, Dept Patol, Area Farmacol, Mendoza, Argentina.
   [Mocayar Maron, Feres Jose; Manucha, Walter] Consejo Nacl Invest Cient & Tecn, Inst Med & Biol Expt Cuyo IMBECU, Mendoza, Argentina.
   [Ferder, Leon] Univ Miami, Miller Sch Med, Dept Pediat, Div Nephrol, Miami, FL 33136 USA.
   [Reiter, Russel J.] Univ Texas Hlth Sci San Antonio, Dept Cellular & Struct Biol, San Antonio, TX USA.
C3 University Nacional Cuyo Mendoza; Consejo Nacional de Investigaciones
   Cientificas y Tecnicas (CONICET); Instituto de Medicina y BiologIa
   Experimental de Cuyo (IMBECU); University of Miami; University of Texas
   System; University of Texas Health Science Center at San Antonio
RP Manucha, W (corresponding author), Univ Nacl Cuyo, Fac Ciencias Med, Dept Patol, Area Farmacol, Mendoza, Argentina.
EM wmanucha@yahoo.com.ar
RI Reiter, Russel/D-3221-2009
OI Manucha, Walter/0000-0002-2279-7626
FU Secretaria de Ciencia, Tecnica y Postgrado, Universidad Nacional de
   Cuyo; ANPCyT (Agencia Nacional de Promocion de la Ciencia y la
   Tecnologia) [PICT 2016-4541]
FX This study was funded by grants from Secretaria de Ciencia, Tecnica y
   Postgrado, Universidad Nacional de Cuyo, and from ANPCyT (Agencia
   Nacional de Promocion de la Ciencia y la Tecnologia, grant number PICT
   2016-4541), both awarded to W. Manucha.
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NR 239
TC 65
Z9 66
U1 0
U2 27
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0960-0760
EI 1879-1220
J9 J STEROID BIOCHEM
JI J. Steroid Biochem. Mol. Biol.
PD MAY
PY 2020
VL 199
AR 105595
DI 10.1016/j.jsbmb.2020.105595
PG 11
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA LD6BV
UT WOS:000526116100031
PM 31954766
DA 2025-06-11
ER

PT J
AU Koncsos, G
   Varga, ZV
   Baranyai, T
   Boengler, K
   Rohrbach, S
   Li, L
   Schlüter, KD
   Schreckenberg, R
   Radovits, T
   Oláh, A
   Mátyás, C
   Lux, A
   Al-Khrasani, M
   Komlódi, T
   Bukosza, N
   Máthé, D
   Deres, L
   Barteková, M
   Rajtík, T
   Adameová, A
   Szigeti, K
   Hamar, P
   Helyes, Z
   Tretter, L
   Pacher, P
   Merkely, B
   Giricz, Z
   Schulz, R
   Ferdinandy, P
AF Koncsos, Gabor
   Varga, Zoltan V.
   Baranyai, Tamas
   Boengler, Kerstin
   Rohrbach, Susanne
   Li, Ling
   Schlueter, Klaus-Dieter
   Schreckenberg, Rolf
   Radovits, Tamas
   Olah, Attila
   Matyas, Csaba
   Lux, Arpad
   Al-Khrasani, Mahmoud
   Komlodi, Timea
   Bukosza, Nora
   Mathe, Domokos
   Deres, Laszlo
   Bartekova, Monika
   Rajtik, Tomas
   Adameova, Adriana
   Szigeti, Krisztian
   Hamar, Peter
   Helyes, Zsuzsanna
   Tretter, Laszlo
   Pacher, Pal
   Merkely, Bela
   Giricz, Zoltan
   Schulz, Rainer
   Ferdinandy, Peter
TI Diastolic dysfunction in prediabetic male rats: Role of mitochondrial
   oxidative stress
SO AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
LA English
DT Article
DE obesity; type 2 diabetes; high-fat diet; reactive oxygen species;
   diabetic cardiomyopathy
ID IMPAIRED FASTING GLUCOSE; HIGH-FAT DIET; LEFT-VENTRICULAR HYPERTROPHY;
   INDUCED CARDIAC-HYPERTROPHY; OXIDASE 4 NOX4; CONTRACTILE DYSFUNCTION;
   CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; DIABETES-MELLITUS;
   ANIMAL-MODELS
AB Although incidence and prevalence of prediabetes are increasing, little is known about its cardiac effects. Therefore, our aim was to investigate the effect of prediabetes on cardiac function and to characterize parameters and pathways associated with deteriorated cardiac performance. Long-Evans rats were fed with either control or high-fat chow for 21 wk and treated with a single low dose (20 mg/kg) of streptozotocin at week 4. High-fat and streptozotocin treatment induced prediabetes as characterized by slightly elevated fasting blood glucose, impaired glucose and insulin tolerance, increased visceral adipose tissue and plasma leptin levels, as well as sensory neuropathy. In prediabetic animals, a mild diastolic dysfunction was observed, the number of myocardial lipid droplets increased, and left ventricular mass and wall thickness were elevated; however, no molecular sign of fibrosis or cardiac hypertrophy was shown. In prediabetes, production of reactive oxygen species was elevated in subsarcolemmal mitochondria. Expression of mitofusin-2 was increased, while the phosphorylation of phos-pholamban and expression of Bcl-2/adenovirus E1B 19-kDa protein-interacting protein 3 (BNIP3, a marker of mitophagy) decreased. However, expression of other markers of cardiac auto-and mitophagy, mitochondrial dynamics, inflammation, heat shock proteins, Ca2+/calmodulin-dependent protein kinase II, mammalian target of rapamycin, or apoptotic pathways were unchanged in prediabetes. This is the first comprehensive analysis of cardiac effects of prediabetes indicating that mild diastolic dysfunction and cardiac hypertrophy are multifactorial phenomena that are associated with early changes in mitophagy, cardiac lipid accumulation, and elevated oxidative stress and that prediabetes-induced oxidative stress originates from the subsarcolemmal mitochondria.
C1 [Koncsos, Gabor; Varga, Zoltan V.; Baranyai, Tamas; Al-Khrasani, Mahmoud; Pacher, Pal; Giricz, Zoltan; Ferdinandy, Peter] Semmelweis Univ, Fac Med, Dept Pharmacol & Pharmacotherapy, Budapest, Hungary.
   [Boengler, Kerstin; Rohrbach, Susanne; Li, Ling; Schlueter, Klaus-Dieter; Schreckenberg, Rolf; Schulz, Rainer] Justus Liebig Univ, Fac Med, Inst Physiol, Giessen, Germany.
   [Radovits, Tamas; Olah, Attila; Matyas, Csaba; Lux, Arpad; Merkely, Bela] Semmelweis Univ, Heart & Vasc Ctr, Budapest, Hungary.
   [Komlodi, Timea; Tretter, Laszlo] Semmelweis Univ, Fac Med, Dept Med Biochem, Budapest, Hungary.
   [Bukosza, Nora; Hamar, Peter] Semmelweis Univ, Fac Med, Inst Pathophysiol, Budapest, Hungary.
   [Mathe, Domokos; Szigeti, Krisztian] Semmelweis Univ, Fac Med, Dept Biophys & Radiat Biol, Budapest, Hungary.
   [Mathe, Domokos] CROmed Translat Res Ctr, Budapest, Hungary.
   [Deres, Laszlo] Univ Pecs, Fac Med, Dept Internal Med 1, Pecs, Hungary.
   [Bartekova, Monika] Comenius Univ, Fac Med, Inst Physiol, Bratislava, Slovakia.
   [Bartekova, Monika] Slovak Acad Sci, Inst Heart Res, Bratislava, Slovakia.
   [Rajtik, Tomas; Adameova, Adriana] Comenius Univ, Fac Pharm, Dept Pharmacol & Toxicol, Bratislava, Slovakia.
   [Helyes, Zsuzsanna] Univ Pecs, Fac Med, Dept Pharmacol & Pharmacotherapy, Pecs, Hungary.
   [Helyes, Zsuzsanna] Univ Pecs, Szentagothai Res Ctr, Pecs, Hungary.
   [Helyes, Zsuzsanna] Univ Pecs, MTA PTE NAP Chron Pain Res Grp B, Pecs, Hungary.
   [Varga, Zoltan V.; Pacher, Pal] NIAAA, Lab Cardiovasc Physiol & Tissue Injury, NIH, Bethesda, MD USA.
C3 Semmelweis University; Justus Liebig University Giessen; Semmelweis
   University; Semmelweis University; Semmelweis University; Semmelweis
   University; University of Pecs; Comenius University Bratislava; Slovak
   Academy of Sciences; Slovak Academy of Sciences; Institute for Heart
   Research, SAS; Comenius University Bratislava; University of Pecs;
   University of Pecs; University of Pecs; National Institutes of Health
   (NIH) - USA; NIH National Institute on Alcohol Abuse & Alcoholism
   (NIAAA)
RP Giricz, Z (corresponding author), Nagyvarad Ter 4, H-1089 Budapest, Hungary.
EM giricz.zoltan@med.semmelweis-univ.hu
RI Giricz, Zoltán/B-6990-2008; Bartekova, Monika/GSI-4927-2022; Schulz,
   Rainer/ABD-5069-2021; Tretter, Laszlo/ACI-2689-2022; Hamar,
   Peter/A-8996-2010; Rohrbach, Susanne/MCY-1480-2025; adameova,
   adriana/HZK-8075-2023; Ferdinandy, Péter/H-9181-2019; Komlódi,
   Tímea/L-4983-2016; Al-Khrasani, Mahmoud/J-9661-2017; Zsuzsanna,
   Helyes/GLU-8236-2022; Pacher, Pal/B-6378-2008; Matyas,
   Csaba/K-6053-2016; Varga, Zoltan/J-9264-2017
OI Pacher, Pal/0000-0001-7036-8108; Schulz, Rainer/0000-0003-3017-0476;
   Matyas, Csaba/0000-0001-6095-7611; Helyes,
   Zsuzsanna/0000-0003-2435-4367; Adameova, Adriana/0000-0002-9803-043X;
   Mathe, Domokos/0000-0001-7343-0413; Bartekova,
   Monika/0000-0002-5210-5184; Rajtik, Tomas/0000-0002-8320-5276; Varga,
   Zoltan/0000-0002-2758-0784
FU European Foundation for the Study of Diabetes (EFSD) New Horizons
   Collaborative Research Initiative from the European Association for the
   Study of Diabetes (EASD); Hungarian Scientific Research Fund [OTKA K
   109737, PD100245]; Slovak Scientific Grant Agency [VEGA1/0638/12];
   Hungarian Academy of Sciences; Rosztoczy Foundation; European
   Cooperation in Science and Technology [COST-BM1203-STSM 090515-058721];
   German Research Foundation [BO-2955/2-1, SCHU 843/9-1]
FX This work was supported by the European Foundation for the Study of
   Diabetes (EFSD) New Horizons Collaborative Research Initiative from the
   European Association for the Study of Diabetes (EASD) and Hungarian
   Scientific Research Fund (OTKA K 109737, PD100245 to T. Radovits) and
   Slovak Scientific Grant Agency (VEGA1/0638/12). Z. Giricz, T. Radovits,
   and K. Szigeti hold a "Janos Bolyai Research Scholarship" from the
   Hungarian Academy of Sciences, and Z. Varga was supported by the
   Rosztoczy Foundation. P. Ferdinandy is a Szentagothai Fellow of the
   National Program of Excellence (TAMOP 4.2.4. A/2-11-1-2012-0001). T.
   Baranyai is supported by the European Cooperation in Science and
   Technology (COST-BM1203-STSM 090515-058721). K. Boengler and R.
   Schreckenberg are supported by the German Research Foundation
   (BO-2955/2-1 and SCHU 843/9-1).
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NR 86
TC 69
Z9 76
U1 1
U2 42
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0363-6135
EI 1522-1539
J9 AM J PHYSIOL-HEART C
JI Am. J. Physiol.-Heart Circul. Physiol.
PD OCT
PY 2016
VL 311
IS 4
BP H927
EP H943
DI 10.1152/ajpheart.00049.2016
PG 17
WC Cardiac & Cardiovascular Systems; Physiology; Peripheral Vascular
   Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Physiology
GA EF1WP
UT WOS:000390116100007
PM 27521417
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Ryter, SW
   Cloonan, SM
   Choi, AMK
AF Ryter, Stefan W.
   Cloonan, Suzanne M.
   Choi, Augustine M. K.
TI Autophagy: A critical regulator of cellular metabolism and homeostasis
SO MOLECULES AND CELLS
LA English
DT Review
DE autophagy; innate immunity; metabolism; mitophagy; neurodegeneration;
   proteostasis
ID HEPATITIS-B-VIRUS; MAMMALIAN AUTOPHAGY; AGGRESOME FORMATION; MEDIATED
   AUTOPHAGY; MOUSE MODEL; PROMOTES; DISEASE; ALPHA-1-ANTITRYPSIN;
   MACROAUTOPHAGY; PARKINSONS
AB Autophagy is a dynamic process by which cytosolic material, including organelles, proteins, and pathogens, are sequestered into membrane vesicles called autophagosomes, and then delivered to the lysosome for degradation. By recycling cellular components, this process provides a mechanism for adaptation to starvation. The regulation of autophagy by nutrient signals involves a complex network of proteins that include mammalian target of rapamycin, the class III phosphatidylinositol-3 kinase/Beclin 1 complex, and two ubiquitin-like conjugation systems. Additionally, autophagy, which can be induced by multiple forms of chemical and physical stress, including endoplasmic reticulum stress, and hypoxia, plays an integral role in the mammalian stress response. Recent studies indicate that, in addition to bulk assimilation of cytosol, autophagy may proceed through selective pathways that target distinct cargoes to autophagosomes. The principle homeostatic functions of autophagy include the selective clearance of aggregated protein to preserve proteostasis, and the selective removal of dysfunctional mitochondria (mitophagy). Additionally, autophagy plays a central role in innate and adaptive immunity, with diverse functions such as regulation of inflammatory responses, antigen presentation, and pathogen clearance. Autophagy can preserve cellular function in a wide variety of tissue injury and disease states, however, maladaptive or pro-pathogenic outcomes have also been described. Among the many diseases where autophagy may play a role include proteopathies which involve aberrant accumulation of proteins (e.g., neurodegenerative disorders), infectious diseases, and metabolic disorders such as diabetes and metabolic syndrome. Targeting the autophagy pathway and its regulatory components may eventually lead to the development of therapeutics.
C1 [Ryter, Stefan W.; Cloonan, Suzanne M.; Choi, Augustine M. K.] Harvard Univ, Brigham & Womens Hosp, Sch Med, Boston, MA 02115 USA.
C3 Harvard University; Harvard Medical School; Harvard University Medical
   Affiliates; Brigham & Women's Hospital
RP Ryter, SW (corresponding author), Harvard Univ, Brigham & Womens Hosp, Sch Med, Boston, MA 02115 USA.
EM sryter@partners.org
OI Cloonan, Suzanne/0000-0001-5301-9926
FU NIH [P01 HL108801, R01 HL079904]; Brigham and Women's Hospital; Lovelace
   Respiratory Research Institute Consortium for Lung Research
FX Funding for this work was from NIH grants P01 HL108801 and R01 HL079904
   to AMKC. SWR received additional salary support from the Brigham and
   Women's Hospital and Lovelace Respiratory Research Institute Consortium
   for Lung Research.
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NR 107
TC 274
Z9 313
U1 0
U2 80
PU KOREAN SOC MOLECULAR & CELLULAR  BIOLOGY
PI SEOUL
PA 635-4, YUCKSAM-DONG, GANGNAM-GU, SEOUL 135-703, SOUTH KOREA
SN 1016-8478
EI 0219-1032
J9 MOL CELLS
JI Mol. Cells
PD JUL
PY 2013
VL 36
IS 1
BP 7
EP 16
DI 10.1007/s10059-013-0140-8
PG 10
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA 187KV
UT WOS:000322118500002
PM 23708729
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Valenti, L
   Swinkels, DW
   Burdick, L
   Dongiovanni, P
   Tjalsma, H
   Motta, BM
   Bertelli, C
   Fatta, E
   Bignamini, D
   Rametta, R
   Fargion, S
   Fracanzani, AL
AF Valenti, L.
   Swinkels, D. W.
   Burdick, L.
   Dongiovanni, P.
   Tjalsma, H.
   Motta, B. M.
   Bertelli, C.
   Fatta, E.
   Bignamini, D.
   Rametta, R.
   Fargion, S.
   Fracanzani, A. L.
TI Serum ferritin levels are associated with vascular damage in patients
   with nonalcoholic fatty liver disease
SO NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
LA English
DT Article
DE Atherosclerosis; Iron; Nonalcoholic fatty liver disease; Oxidative
   stress; Vascular damage
ID OXIDATIVE STRESS; IRON DEPLETION; HEART-DISEASE; HFE MUTATIONS;
   HEPCIDIN; EXPRESSION; HEMOCHROMATOSIS; RISK; ACCUMULATION; MACROPHAGES
AB Background and aims: Increased ferritin and body iron stores are frequently observed in nonalcoholic fatty liver disease (NAFLD), associated with heightened susceptibility to vascular damage. Conflicting data have been reported on the role of iron in atherosclerosis, with recent data suggesting that excess iron induces vascular damage by increasing levels of the hormone hepcidin, which would determine iron trapping into macrophages, oxidative stress, and promotion of transformation into foam cells. Aim of this study was to investigate the relationship between iron status and cardiovascular damage in NAFLD.
   Methods and results: Vascular damage was evaluated by common carotid arteries intima-media thickness (CC-IMT) measurement and plaque detection by ecocolor-doppler ultrasonography in 506 patients with clinical and ultrasonographic diagnosis of NAFLD, hemochromatosis gene (HFE) mutations by restriction analysis in 342 patients. Serum hepcidin-25 was measured by time-of-flight mass spectrometry in 143 patients. At multivariate analysis CC-IMT was associated with systolic blood pressure, glucose, LDL cholesterol, abdominal circumference, age, and ferritin (p = 0.048). Carotid plaques were independently associated with age, ferritin, glucose, and hypertension. Ferritin reflected iron stores and metabolic syndrome components, but not inflammation or liver damage. Hyperferritinemia was associated with increased vascular damage only in patients with HFE genotypes associated with hepcidin upregulation by iron stores (p < 0.0001), and serum hepcidin-25 was independently associated with carotid plaques (p = 0.05).
   Conclusion: Ferritin levels, reflecting iron stores, are independent predictors of vascular damage in NAFLD. The mechanism may involve upregulation of hepcidin by increased iron stores in patients not carrying HFE mutations, and iron compartmentalization into macrophages. (c) 2010 Elsevier B.V. All rights reserved.
C1 [Valenti, L.; Burdick, L.; Dongiovanni, P.; Motta, B. M.; Bertelli, C.; Fatta, E.; Bignamini, D.; Rametta, R.; Fargion, S.; Fracanzani, A. L.] Univ Milan, Ctr Study Metab & Liver Dis, Hosp Fdn Policlin MaRE IRCCS, Dept Internal Med, I-20122 Milan, Italy.
   [Swinkels, D. W.; Tjalsma, H.] Radboud Univ Nijmegen, Med Ctr, Dept Clin Chem, NL-6525 ED Nijmegen, Netherlands.
C3 University of Milan; Radboud University Nijmegen
RP Fargion, S (corresponding author), Univ Milan, Ctr Study Metab & Liver Dis, Hosp Fdn Policlin MaRE IRCCS, Dept Internal Med, Via F Sforza 35, I-20122 Milan, Italy.
EM luca.valenti@unimi.it; d.swinkels@akc.umcn.nl;
   larryburdick@policlinico.mi.it; paola.dongiovanni@unimi.it;
   h.tjalsms@akc.umcn.nl; benedetta.motta1@studenti.unimi.it;
   cristinagiuliabertelli@yahoo.it; erikaiki@yahoo.it;
   danibigna@fastwebnet.it; raffaela_rametta@yahoo.it;
   silvia.fargion@unimi.it; anna.fracanzani@unimi.it
RI Dongiovanni, Paola/AAC-9965-2019; Motta, Benedetta/AAA-8559-2020;
   Tjalsma, Harold/I-7146-2012; Swinkels, Dorine/H-8098-2014; Fracanzani,
   Anna Ludovica/J-8986-2018; Valenti, Luca/B-3695-2009
OI Fracanzani, Anna Ludovica/0000-0001-5918-0171; Dongiovanni,
   Paola/0000-0003-4343-7213; rametta, raffaela/0000-0003-0091-9394; Motta,
   Benedetta Maria/0000-0002-6681-2170; Valenti, Luca/0000-0001-8909-0345
FU FIRST/PUR University of Milano; Ricerca Corrente; Fondazione Ospedale
   Policlinico MaRE IRCCS
FX Grant support: FIRST/PUR University of Milano 2006-2008; Ricerca
   Corrente 2006, 2007 and Progetto a Concorso 2009-2010 Fondazione
   Ospedale Policlinico MaRE IRCCS.
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NR 32
TC 73
Z9 75
U1 0
U2 13
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0939-4753
EI 1590-3729
J9 NUTR METAB CARDIOVAS
JI Nutr. Metab. Carbiovasc. Dis.
PD AUG
PY 2011
VL 21
IS 8
BP 568
EP 575
DI 10.1016/j.numecd.2010.01.003
PG 8
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism; Nutrition
   & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism;
   Nutrition & Dietetics
GA 803QW
UT WOS:000293596800005
PM 20392616
DA 2025-06-11
ER

PT J
AU Wheatcroft, SB
   Williams, IL
   Shah, AM
   Kearney, MT
AF Wheatcroft, SB
   Williams, IL
   Shah, AM
   Kearney, MT
TI Pathophysiological implications of insulin resistance on vascular
   endothelial function
SO DIABETIC MEDICINE
LA English
DT Review
DE endothelial dysfunction; insulin resistance; atherosclerosis; nitric
   oxide; Type 2 diabetes mellitus
ID NITRIC-OXIDE SYNTHASE; NECROSIS-FACTOR-ALPHA;
   ANGIOTENSIN-CONVERTING-ENZYME; CORONARY-HEART-DISEASE; C-REACTIVE
   PROTEIN; FREE FATTY-ACIDS; PHOSPHATIDYLINOSITOL 3-KINASE ACTIVITY;
   RECEPTOR SUBSTRATE-1 PHOSPHORYLATION; STIMULATED GLUT4 TRANSLOCATION;
   COA-REDUCTASE INHIBITORS
AB Background Insulin resistance is a key component of the insulin resistance syndrome and is a crucially important metabolic abnormality in Type 2 diabetes. Insulin-resistant individuals are at significantly increased risk of cardiovascular disease, although the underlying mechanisms remain incompletely understood. The endothelium is thought to play a critical role in maintaining vascular homeostasis, a process dependent on the balance between the production of nitric oxide, superoxide and other vasoactive substances. Endothelial dysfunction has been demonstrated in insulin-resistant states in animals and humans and may represent an important early event in the development of atherosclerosis. Insulin resistance may be linked to endothelial dysfunction by a number of mechanisms, including disturbances of subcellular signalling pathways common to both insulin action and nitric oxide production. Other potential unifying links include the roles of oxidant stress, endothelin, the renin angiotensin system and the secretion of hormones and cytokines by adipose tissue. Lifestyle measures and drug therapies which improve insulin sensitivity and ameliorate endothelial dysfunction may be important in delaying the progression to overt cardiovascular disease in at risk individuals.
   Methods We conducted a literature search using Medline, restricted to articles published in the English language between 1966 and the present, and reviewed bibliographies of relevant articles. An initial search strategy employing combinations of the MeSH terms: insulin resistance; endothelium, vascular; insulin; nitric oxide or hyperinsulinaemia produced over 300 references. Focused searches using keywords relevant to the molecular aspects of endothelial function and insulin signalling, and lifestyle or pharmacological interventions relevant to insulin resistance or endothelial function, produced over 300 further references. Abstracts of all references were screened before selecting those relevant to this review.
C1 Kings Coll London, Guys Kings & St Thomas Sch Med, Dept Cardiol, London SE5 9PJ, England.
C3 University of London; King's College London
RP Kings Coll London, Guys Kings & St Thomas Sch Med, Dept Cardiol, London SE5 9PJ, England.
EM stephen.wheatcroft@kcl.ac.uk
RI Shah, Amy/AAB-4631-2020
OI Shah, Ajay/0000-0002-6547-0631
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NR 230
TC 222
Z9 254
U1 0
U2 8
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0742-3071
EI 1464-5491
J9 DIABETIC MED
JI Diabetic Med.
PD APR
PY 2003
VL 20
IS 4
BP 255
EP 268
DI 10.1046/j.1464-5491.2003.00869.x
PG 14
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 664CB
UT WOS:000182043200001
PM 12675638
DA 2025-06-11
ER

PT J
AU Habib, SA
   Saad, EA
   Elsharkawy, AA
   Attia, ZR
AF Habib, Salem A.
   Saad, Entsar A.
   Elsharkawy, Ashraf A.
   Attia, Zeinab R.
TI Pro-inflammatory adipocytokines, oxidative stress, insulin, Zn and Cu:
   Interrelations with obesity in Egyptian non-diabetic obese children and
   adolescents
SO ADVANCES IN MEDICAL SCIENCES
LA English
DT Article
DE Obesity; Adipocytokines; Oxidative stress; Insulin; Micronutrients
ID ZINC NUTRITIONAL-STATUS; SERUM LEPTIN LEVELS; METABOLIC SYNDROME;
   PLASMA; INTERLEUKIN-6; RESISTANCE; BLOOD; ADIPONECTIN; SENSITIVITY;
   MECHANISMS
AB Purpose: To investigate the inter-relationships between adipocytokines, oxidative stress, insulin, Zn and Cu and obesity among Egyptian obese non-diabetic children and adolescents.
   Patients and methods: 72 obese children and adolescents of both sexes (5-17 years) were recruited for the study. 40 healthy normal non-obese persons of matched ages and sexes were used as control group. Lipid profile, tumor necrosis factor alpha (TNF-alpha), interleukin-6 (IL-6) and leptin levels were measured. Malondialdehyde (MDA) and reduced glutathione (GSH) concentrations and superoxide dismutase (SOD) activity were estimated. Micronutrients (Zn and Cu) concentrations in addition to insulin and fasting blood sugar (FBS) levels were also evaluated. Estimation of insulin resistance (homeostatic model assessment (HOMA-IR)) was derived from FBS measurements.
   Results: Significant elevations (P < 0.001) in TNF-alpha, IL-6, leptin, MDA, Cu and FBS levels and significant decreases (P < 0.001) in GSH, Zn levels and SOD activity were detected among obese individuals as compared with control group. Insulin and triglyceride levels were significantly increased in obese male children and HDL-cholesterol level was increased significantly in obese adolescent females compared to controls. However, total cholesterol and LDL-cholesterol levels were significantly high in all obese cases as compared with controls. Insulin resistance was detected in 100% of the patients.
   Conclusions: We concluded that obesity with pro-inflammatory adipocytokines and hypozincemia together by many mechanisms participate in excessive oxidative stress and are highly associated with inflammation and the development of obesity-related complications. Obesity represents a critical risk factor for development of insulin resistance status. (C) 2015 Medical University of Bialystok. Published by Elsevier Sp. z o.o. All rights reserved.
C1 [Habib, Salem A.; Saad, Entsar A.; Attia, Zeinab R.] Damietta Univ, Fac Sci, Dept Chem, Dumyat, Egypt.
   [Habib, Salem A.] Tabuk Univ, Fac Sci, Dept Biochem, Tabuk, Saudi Arabia.
   [Elsharkawy, Ashraf A.] Mansoura Univ, Childrens Hosp, Mansoura, Egypt.
C3 Egyptian Knowledge Bank (EKB); Damietta University; University of Tabuk;
   Egyptian Knowledge Bank (EKB); Mansoura University
RP Saad, EA (corresponding author), Damietta Univ, Fac Sci, Dept Chem, Mobarak St, Dumyat, Egypt.
EM entsarsaad@gmail.com
RI Attia, zeinab/JCO-8282-2023; Elsharkawy, Asharf/Q-3837-2018; Saad,
   Entsar/D-4540-2015
OI Attia, zeinab/0000-0003-1907-5419; Saad, Entsar/0000-0001-6477-8098
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NR 58
TC 59
Z9 61
U1 0
U2 9
PU ELSEVIER URBAN & PARTNER SP Z O O
PI WROCLAW
PA UL MIGDALOWA 4, LOK 59, WROCLAW, 02-796, POLAND
SN 1896-1126
EI 1898-4002
J9 ADV MED SCI-POLAND
JI Adv. Med. Sci.
PD SEP
PY 2015
VL 60
IS 2
BP 179
EP 185
DI 10.1016/j.advms.2015.02.002
PG 7
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA CU3GS
UT WOS:000363413000001
PM 25827128
DA 2025-06-11
ER

PT J
AU Xu, XJ
   Gauthier, MS
   Hess, DT
   Apovian, CM
   Cacicedo, JM
   Gokce, N
   Farb, M
   Valentine, RJ
   Ruderman, NB
AF Xu, X. Julia
   Gauthier, Marie-Soleil
   Hess, Donald T.
   Apovian, Caroline M.
   Cacicedo, Jose M.
   Gokce, Noyan
   Farb, Melissa
   Valentine, Rudy J.
   Ruderman, Neil B.
TI Insulin sensitive and resistant obesity in humans: AMPK activity,
   oxidative stress, and depot-specific changes in gene expression in
   adipose tissue
SO JOURNAL OF LIPID RESEARCH
LA English
DT Article
DE insulin sensitivity; adenosine monophosphate-activated protein kinase;
   inflammation
ID ACTIVATED PROTEIN-KINASE; METABOLIC SYNDROME; ENDOTHELIAL-CELLS;
   LIPID-METABOLISM; SKELETAL-MUSCLE; MALONYL-COA; INFLAMMATION; GLUCOSE;
   SIRT1; MECHANISM
AB We previously reported that adenosine monophosphate-activated protein kinase (AMPK) activity is lower in adipose tissue of morbidly obese individuals who are insulin resistant than in comparably obese people who are insulin sensitive. However, the number of patients and parameters studied were small. Here, we compared abdominal subcutaneous, epiploic, and omental fat from 16 morbidly obese individuals classified as insulin sensitive or insulin resistant based on the homeostatic model assessment of insulin resistance. We confirmed that AMPK activity is diminished in the insulin resistant group. A custom PCR array revealed increases in mRNA levels of a wide variety of genes associated with inflammation and decreases in PGC-1 alpha and Nampt in omental fat of the insulin resistant group. In contrast, subcutaneous abdominal fat of the same patients showed increases in PTP-1b, VEGFa, IFN gamma, PAI-1, and NOS-2 not observed in omental fat. Only angiotensinogen and CD4(+) mRNA levels were increased in both depots.(jlr) Surprisingly, TNF alpha was only increased in epiploic fat, which otherwise showed very few changes. Protein carbonyl levels, a measure of oxidative stress, were increased in all depots. Thus, adipose tissues of markedly obese insulin resistant individuals uniformly show decreased AMPK activity and increased oxidative stress compared with insulin sensitive patients. However, most changes in gene expression appear to be depot-specific.-Xu, X. J., M-S. Gauthier, D. T. Hess, C. M. Apovian, J. M. Cacicedo, N. Gokce, M. Farb, R. J. Valentine, and N. B. Ruderman. Insulin sensitive and resistant obesity in humans: AMPK activity, oxidative stress, and depot-specific changes in gene expression in adipose tissue. J. Lipid Res. 2012. 53: 792-801.
C1 [Xu, X. Julia; Gauthier, Marie-Soleil; Apovian, Caroline M.; Cacicedo, Jose M.; Valentine, Rudy J.; Ruderman, Neil B.] Boston Univ, Sch Med, Diabet & Metab Unit, Boston, MA 02118 USA.
   [Hess, Donald T.] Boston Univ, Sch Med, Dept Med, Endocrinol Sect,Dep Surg, Boston, MA 02118 USA.
   [Gokce, Noyan; Farb, Melissa] Boston Univ, Sch Med, Whitaker Cardiovasc Inst, Boston, MA 02118 USA.
C3 Boston University; Boston University; Boston University
RP Ruderman, NB (corresponding author), Boston Univ, Sch Med, Diabet & Metab Unit, Boston, MA 02118 USA.
EM nrude@bu.edu
OI Xu, Julia/0000-0002-2564-8052; Apovian, Caroline/0000-0002-8029-1922;
   Gokce, Noyan/0000-0003-2920-3445; /0000-0001-8417-9754; Ruderman,
   Neil/0000-0002-6589-6587; Hess, Donald/0000-0003-2464-5025
FU National Institutes of Health [R01-DK19514, P01-HL068758, R01HL084213,
   P01 HL 081587]; American Diabetes Association [ADA-7-11-MN-43]; Fonds de
   la Recherche en Sante du Quebec; American Heart Association [T32
   HL07224]
FX This work was supported by National Institutes of Health grants
   R01-DK19514 and P01-HL068758 (to N.B.R.), a mentor-based Fellowship
   Grant from the American Diabetes Association ADA-7-11-MN-43 (to N.B.R),
   and National Institutes of Health grants R01HL084213 and P01 HL 081587
   (to N.G.). Its contents are solely the responsibility of the authors and
   do not necessarily represent the official views of the National
   Institutes of Health or other granting agencies. M-S. G. was supported
   by a postdoctoral research fellowship from Fonds de la Recherche en
   Sante du Quebec and is presently a Canadian Diabetes Association fellow.
   M. F. and R. V. were supported by T32 HL07224 training grant from the
   American Heart Association. None of the authors has a conflict of
   interest relevant to this manuscript.
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NR 63
TC 174
Z9 184
U1 0
U2 20
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0022-2275
EI 1539-7262
J9 J LIPID RES
JI J. Lipid Res.
PD APR
PY 2012
VL 53
IS 4
BP 792
EP 801
DI 10.1194/jlr.P022905
PG 10
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 907PY
UT WOS:000301431000018
PM 22323564
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Lionetti, L
   Mollica, MP
   Lombardi, A
   Cavaliere, G
   Gifuni, G
   Barletta, A
AF Lionetti, L.
   Mollica, M. P.
   Lombardi, A.
   Cavaliere, G.
   Gifuni, G.
   Barletta, A.
TI From chronic overnutrition to insulin resistance: The role of
   fat-storing capacity and inflammation
SO NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
LA English
DT Review
DE Hypertrophic adipocyte; Endoplasmic reticulum stress; Inflammation;
   Lipotoxicity
ID ENDOPLASMIC-RETICULUM STRESS; MONOCYTE CHEMOATTRACTANT PROTEIN-1;
   TOLL-LIKE RECEPTOR; ADIPOSE-TISSUE CELLULARITY; FACTOR-KAPPA-B;
   METABOLIC SYNDROME; SKELETAL-MUSCLE; GENE-EXPRESSION; ADIPOCYTE SIZE;
   CELL-DEATH
AB Aims: We analyze how the inflammatory state in adipose tissue caused by a condition of chronically positive energy balance can lead to insulin resistance first in adipose tissue, then in all insulin-sensitive tissues.
   Data synthesis: Chronic nutrient overload causes an increase in adipose depots that, if adipose tissue expandability is tow, are characterized by an increased presence of hypertrophic adipocytes. This adipocyte hypertrophy is a possible stress condition for the endoplasmic reticulum (ER) that would lead to a proinflammatory state in adipose tissue. In this condition, ER stress would activate metabolic pathways that trigger insulin resistance, release of macrophage chemoattractant proteins, and in chronic inflammation, the death of the hypertrophic adipocyte. The infiltrated macrophages in turn release inflammatory proteins causing further recruitment of macrophages to adipose tissue and the release of inflammatory cytokines. Following these events, insulin resistance becomes extended to all adipose tissue. Insulin-resistant adipocytes, characterized by low liposynthetic capacity and high lipolytic capacity, cause increased release of free fatty acids (FFA). FFA released by lipolitic adipocytes may also activate Toll-like receptors 4 and then chemokines and cytokines release amplifying insulin resistance, lipolysis and inflammation in all. adipose tissue. Moreover, increased circulating FFA levels, reduced circulating adiponectin levels and leptin resistance lead to decreased lipid oxidation in non-adipose tissues, thereby triggering ectopic accumulation of lipids, lipotoxicity and insulin resistance.
   Conclusion: All. the conditions that increase circulating fatty acids and cause lipid overloading (obesity, lipoatrophy, lipodystrophy, catabolic states, etc.) induce a lipotoxic state in non-adipose tissues that gives rise to insulin resistance. (C) 2008 Elsevier B.V. All rights reserved.
C1 [Lionetti, L.; Mollica, M. P.; Lombardi, A.; Cavaliere, G.; Gifuni, G.; Barletta, A.] Univ Naples Federico II, Dept Biol Sci, Physiol Sect, I-80134 Naples, Italy.
C3 University of Naples Federico II
RP Barletta, A (corresponding author), Univ Naples Federico II, Dept Biol Sci, Physiol Sect, Via Mezzocannone 8, I-80134 Naples, Italy.
EM antonio.barletta@unina.it
RI Lombardi, Assunta/IAS-1054-2023; Lionetti, Lilla/AAM-1756-2021
OI Lionetti, Lilla/0000-0002-4059-8030; Mollica, Maria
   Pina/0000-0003-2726-7779; Lombardi, Assunta/0009-0002-0553-1655
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NR 76
TC 165
Z9 195
U1 2
U2 28
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0939-4753
EI 1590-3729
J9 NUTR METAB CARDIOVAS
JI Nutr. Metab. Carbiovasc. Dis.
PD FEB
PY 2009
VL 19
IS 2
BP 146
EP 152
DI 10.1016/j.numecd.2008.10.010
PG 7
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism; Nutrition
   & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism;
   Nutrition & Dietetics
GA 427ZE
UT WOS:000264816800013
PM 19171470
DA 2025-06-11
ER

PT J
AU Lee, W
   Min, WK
   Chun, S
   Jang, S
   Kim, JQ
   Lee, DH
   Park, JY
   Park, H
   Son, JE
AF Lee, W
   Min, WK
   Chun, S
   Jang, S
   Kim, JQ
   Lee, DH
   Park, JY
   Park, H
   Son, JE
TI Low-density lipoprotein subclass and its correlating factors in
   diabetics
SO CLINICAL BIOCHEMISTRY
LA English
DT Article
DE LDL subclass; small-sized LDL proportion; diabetes mellitus
ID CORONARY-ARTERY DISEASE; INSULIN-RESISTANCE SYNDROME; SUBFRACTION
   DISTRIBUTION; MYOCARDIAL-INFARCTION; HEART-DISEASE; RISK FACTOR; LDL
   SIZE; MEN; PLASMA; MELLITUS
AB Objectives: Small dense LDL, low density lipoprotein (LDL) particles with small size and high density, is regarded as a significant risk factor for cardiovascular diseases. Diabetes mellitus is one of the conditions accompanied by increased small dense LDL. We analyzed LDL subclass in type 2 diabetics and normal controls with LipoPrint LDL System to investigate the LDL heterogeneity in diabetics and factors affecting it.
   Design and methods: We selected 40 normal controls and 40 type 2 diabetics with fasting blood glucose level over 7.0 mmol/L and HbA1c level over 7%. LDL subclass was determined with LipoPrint LDL System. LipoPrint LDL System fractionates LDL into seven parts (LDL1-7) by size and LDL3 to LDL7 are defined as small-sized LDL. In addition we estimated 'the percent of small-sized LDL over whole LDL' and defined it as 'small-sized LDL proportion'.
   Results: Mean small-sized LDL proportion was significantly higher in diabetics (23.4%) than in controls (11.8%) (P < 0.001) and small-sized LDL proportion showed positive correlation with blood levels of glucose, HbA1c, total cholesterol, triglyceride, and oxidized LDL and negative correlation with HDL cholesterol level in univariate analysis (p < 0.001). Of these parameters, triglyceride, HbA1c, oxidized LDL were statistically significant variables contributing to the small-sized LDL proportion in stepwise multiple regression analysis.
   Conclusions: We analyzed small-sized LDL proportion in type 2 diabetics and found that it was significantly increased in diabetics than control subjects and it was independently correlated with triglyceride, HbA1c, oxidized LDL in descending order, which are reflecting lipid metabolism, glycation, and oxidative stress, respectively. (C) 2003 The Canadian Society of Clinical Chemists. All rights reserved.
C1 Asan Med Ctr, Dept Lab Med, Seoul, South Korea.
   Univ Ulsan, Coll Med, Seoul, South Korea.
   Seoul Natl Univ, Coll Med, Dept Lab Med, Seoul, South Korea.
   Asan Med Ctr, Dept Internal Med, Seoul, South Korea.
   Univ Ulsan, Coll Med, Seoul, South Korea.
   Kangbuk Samsung Hosp, Dept Lab Med, Seoul, South Korea.
   Sungkyunkwan Univ, Sch Med, Seoul, South Korea.
C3 University of Ulsan; Asan Medical Center; University of Ulsan; Seoul
   National University (SNU); University of Ulsan; Asan Medical Center;
   University of Ulsan; Sungkyunkwan University (SKKU); Samsung Medical
   Center; Sungkyunkwan University (SKKU)
RP Min, WK (corresponding author), Asan Med Ctr, Dept Lab Med, Seoul, South Korea.
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NR 39
TC 20
Z9 22
U1 0
U2 4
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0009-9120
J9 CLIN BIOCHEM
JI Clin. Biochem.
PD NOV
PY 2003
VL 36
IS 8
BP 657
EP 661
DI 10.1016/S0009-9120(03)00109-7
PG 5
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA 750AL
UT WOS:000186962200012
PM 14636882
DA 2025-06-11
ER

PT J
AU Merchant, N
   Rahman, ST
   Ferdinand, KC
   Haque, T
   Umpierrez, GE
   Khan, BV
AF Merchant, N.
   Rahman, S. T.
   Ferdinand, K. C.
   Haque, T.
   Umpierrez, G. E.
   Khan, B. V.
TI Effects of nebivolol in obese African Americans with hypertension
   (NOAAH): markers of inflammation and obesity in response to
   exercise-induced stress
SO JOURNAL OF HUMAN HYPERTENSION
LA English
DT Article
DE exercise-induced stress; obesity; inflammation
ID CORONARY-HEART-DISEASE; UNITED-STATES ADULTS; METABOLIC SYNDROME;
   BLOOD-PRESSURE; DOUBLE-BLIND; ADIPONECTIN; PREVALENCE; AWARENESS; MEN;
   ENDOTHELIUM
AB We sought to determine whether the antihypertensive drug nebivolol has beneficial effects on vascular markers of inflammation and oxidation in obese African-American patients with hypertension when exposed to exercise-induced stress. Forty-three obese, African-American subjects with hypertension were treated with nebivolol (5-10 mg/day) for 8 weeks. Before treatment the subjects underwent an exercise treadmill study to a level of eight metabolic equivalents. Circulating levels of soluble interleukin-6 (sIL-6), vascular cell adhesion molecule (VCAM-1), adiponectin and leptin were measured at pre-treadmill, and 1 min, 30 min, 60 min and 24 h after treadmill. After the 8-week treatment period, exercise treadmill study and the measurement of markers were repeated. Treatment with nebivolol reduced levels of sVCAM-1 at pre-exercise by 21% and at 1 and 30 min by 12.5 and 20%, respectively (P<0.005 from corresponding time point). In nebivolol-treated patients there was a reduction in sIL-6 levels by 20% and pre-exercise and at 1 and 60 min by 19.7 and 33.5%, respectively (P<0.005 from corresponding time point). Treatment with nebivolol increased levels of serum adiponectin by 28% (P = 0.012) and decreased levels of leptin by 32% (P<0.005 from pre-treatment). Treatment with nebivolol improves markers of inflammation and obesity in a high-risk African-American population. Moreover, this effect is potentiated in response to exercise-induced stress. These results suggest that nebivolol differentially regulates markers of inflammation and obesity, thereby providing vascular protection. Journal of Human Hypertension (2011) 25, 196-202; doi:10.1038/jhh.2010.39; published online 8 April 2010
C1 [Khan, B. V.] Emory Univ, Sch Med, Atlanta Vasc Res Fdn, Dept Med,Div Cardiol, Atlanta, GA 30084 USA.
C3 Emory University
RP Khan, BV (corresponding author), Emory Univ, Sch Med, Atlanta Vasc Res Fdn, Dept Med,Div Cardiol, 3562 Habersham Northlake, Atlanta, GA 30084 USA.
EM bkhan@emory.edu
FU National Institutes of Health [DK-R03DK073190]; Forest Pharmaceuticals
FX This study was supported by the National Institutes of Health Grant
   (DK-R03DK073190). Also, the investigators of the study received an
   unrestricted grant and the study drug (nebivolol) from Forest
   Pharmaceuticals. Drs Khan and Ferdinand are on the Scientific Advisory
   Board of Forest Pharmaceuticals. The other authors have no conflicts of
   interest to disclose regarding this study or the preparation of the
   paper.
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NR 30
TC 15
Z9 15
U1 0
U2 1
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0950-9240
EI 1476-5527
J9 J HUM HYPERTENS
JI J. Hum. Hypertens.
PD MAR
PY 2011
VL 25
IS 3
BP 196
EP 202
DI 10.1038/jhh.2010.39
PG 7
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 719HR
UT WOS:000287195400009
PM 20376076
DA 2025-06-11
ER

PT J
AU Wauquier, F
   Ripoche, D
   Boutin-Wittrant, L
   Otero, YF
   Krisa, S
   Valls, J
   Maura, M
   Le Joubioux, F
   Maugard, T
   Bolea, G
   Meyer, G
   Reboul, C
   Roux, V
   Macian, N
   Pickering, G
   Pereira, B
   Bargetto, M
   Sapone, V
   Cazaubiel, M
   Peltier, S
   Sirvent, P
   Wittrant, Y
AF Wauquier, Fabien
   Ripoche, Doriane
   Boutin-Wittrant, Line
   Otero, Yolanda F.
   Krisa, Stephanie
   Valls, Josep
   Maura, Maheva
   Le Joubioux, Florian
   Maugard, Thierry
   Bolea, Gaetan
   Meyer, Gregory
   Reboul, Cyril
   Roux, Veronique
   Macian, Nicolas
   Pickering, Gisele
   Pereira, Bruno
   Bargetto, Maxime
   Sapone, Veronique
   Cazaubiel, Murielle
   Peltier, Sebastien
   Sirvent, Pascal
   Wittrant, Yohann
TI TOTUM-854 Human Circulating Bioactives Preserve Endothelial Cell
   Function
SO NUTRIENTS
LA English
DT Article
DE clinical trial; ex vivo; hypertension; plant extract; oxidative stress;
   lipotoxic stress; human metabolites; human endothelial cells
ID ANGIOTENSIN-CONVERTING ENZYME; BLOOD-PRESSURE; OXIDATIVE STRESS;
   DOUBLE-BLIND; METABOLIC SYNDROME; GARLIC EXTRACT; HYPERTENSION;
   DYSFUNCTION; ADULTS; DIETS
AB Background: TOTUM-854 is a patented plant extract blend characterized by its components that have previously been described for their potential health benefits in limiting hypertension onset. However, most of the literature data remain descriptive regarding the mode of action at the cellular level, especially in humans, and further investigations are required for optimized therapeutic strategies. Methods: We first demonstrated in an L-NAME mouse model that TOTUM-854 supports the prevention of hypertension in vitro and in vivo. Then, we designed an ex vivo clinical innovative approach considering the circulating metabolites produced by the digestive tract upon TOTUM-854 ingestion in humans. Human serum was collected in healthy volunteers before and after the acute intake of 3.71 g of TOTUM-854. The bioavailability of circulating metabolites was confirmed and characterized by UPLC-MS. Human serum containing TOTUM-854-derived metabolites was further processed for incubation with human endothelial cells (HUVECs), in the absence or presence of palmitate (200 mu M). Results: HUVEC protection against lipotoxicity was characterized by (1) decreased ACE-1 activity (-32% p < 0.0001); (2) the inhibition of oxidative stress with decreased ROS (-12% observed by DCFDA and DHE fluorescent microscopy) and decreased Nox2 gene expression (-6.7 fold change vs. palmitate, p < 0.01); and (3) the inhibition of an inflammatory response, with a decrease in IL-1 beta release (-37% compared to palmitate, p < 0.001) and decreased MCP-1 and VCAM-1 gene expression (-93% p < 0.001 and -77% p < 0.001, respectively). Conclusions: Overall, this study provides insightful data regarding the protective role of TOTUM-854 in human endothelial cells. Using an innovative clinical ex vivo approach, our data support the role of TOTUM-854 circulating metabolites in vascular protection in humans.
C1 [Wauquier, Fabien; Boutin-Wittrant, Line; Wittrant, Yohann] ClinicnCell SAS, Fac Med, Lab Pharmacol, 28 Pl Henri Dunant, F-63001 Clermont Ferrand, France.
   [Ripoche, Doriane; Otero, Yolanda F.; Sirvent, Pascal] Valbiotis, 20 rue Henri & Gilberte Goudier, F-63200 Riom, France.
   [Krisa, Stephanie] Univ Bordeaux, INRAE, INP, ISVV, 210 Chem Leysotte,Campus ISVV, F-33140 Villenave Dornon, France.
   [Valls, Josep] MetaboHUB, Bordeaux Metabolome, 210 Chem Leysotte, F-33140 Villenave Dornon, France.
   [Maura, Maheva; Le Joubioux, Florian; Bargetto, Maxime; Sapone, Veronique; Cazaubiel, Murielle; Peltier, Sebastien] Valbiotis, Zone Industrielle 4 Chevaliers,Batiment 12F,Rue Pa, F-17180 Perigny, France.
   [Maugard, Thierry] Rochelle Univ, CNRS, LIENs, 2 Rue Olympe Gouges,Campus NA, F-17000 La Rochelle, France.
   [Bolea, Gaetan; Meyer, Gregory; Reboul, Cyril] Avignon Univ, LAPEC EA 4278, 4278 228 Route Aerodrome, F-84000 Avignon, France.
   [Roux, Veronique; Macian, Nicolas; Pickering, Gisele] CHU Gabriel Montpied, INSERM 1405, Plateforme Invest Clin, CIC, F-63000 Clermont Ferrand, France.
   [Pereira, Bruno] CHU, Biostat Unit, DRCI, F-63000 Clermont Ferrand, France.
   [Wittrant, Yohann] UNH, INRAE, UMR 1019, F-63000 Clermont Ferrand, France.
C3 Universite de Bordeaux; Centre National de la Recherche Scientifique
   (CNRS); CNRS - Institute of Physics (INP); INRAE; Centre National de la
   Recherche Scientifique (CNRS); Avignon Universite; Universite Clermont
   Auvergne (UCA); CHU Clermont Ferrand; Institut National de la Sante et
   de la Recherche Medicale (Inserm); Universite Clermont Auvergne (UCA);
   CHU Clermont Ferrand; INRAE
RP Wittrant, Y (corresponding author), ClinicnCell SAS, Fac Med, Lab Pharmacol, 28 Pl Henri Dunant, F-63001 Clermont Ferrand, France.; Wittrant, Y (corresponding author), UNH, INRAE, UMR 1019, F-63000 Clermont Ferrand, France.
EM fabien.wauquier@clinicncell.com; ripochedoriane@gmail.com;
   line.wittrant@clinicncell.com; stephanie.krisa@u-bordeaux.fr;
   josep.valls-fonayet@u-bordeaux.fr; maheva.maura@valbiotis.com;
   florian.lejoubioux@valbiotis.com; thierry.maugard@univ-lr.fr;
   g.bolea@biophysium.com; gregory.meyer@univ-avignon.fr;
   cyril.reboul@univ-avignon.fr; v_morel@chu-clermontferrand.fr;
   nmacian@chu-clermontferrand.fr; gisele.pickering@uca.fr;
   bpereira@chu-clermontferrand.fr; bargetto.maxime@gmail.com;
   veronique.sapone@valbiotis.com; murielle.cazaubiel@valbiotis.com;
   sebastien.peltier@valbiotis.com; pascal.sirvent@valbiotis.com;
   yohann.wittrant@inrae.fr
OI Pereira, Bruno/0000-0003-3778-7161
FU VALBIOTIS SA; INSERM; University Hospital; MetaboHUB
FX This study was sponsored by VALBIOTIS SA. The contribution of Y.W. was
   supported by INRAE. The contribution of PIC/CIC (V.R., N.M., G.P.) was
   supported by INSERM and the University Hospital. The contribution of S.K
   and J.V was supported by the Bordeaux Metabolome Facility and the
   MetaboHUB.
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NR 54
TC 0
Z9 0
U1 2
U2 2
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD APR 11
PY 2025
VL 17
IS 8
AR 1331
DI 10.3390/nu17081331
PG 19
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 1XO9Y
UT WOS:001476049200001
PM 40284196
DA 2025-06-11
ER

PT J
AU Takada, S
   Kinugawa, S
   Hirabayashi, K
   Suga, T
   Yokota, T
   Takahashi, M
   Fukushima, A
   Homma, T
   Ono, T
   Sobirin, MA
   Masaki, Y
   Mizushima, W
   Kadoguchi, T
   Okita, K
   Tsutsui, H
AF Takada, Shingo
   Kinugawa, Shintaro
   Hirabayashi, Kagami
   Suga, Tadashi
   Yokota, Takashi
   Takahashi, Masashige
   Fukushima, Arata
   Homma, Tsuneaki
   Ono, Taisuke
   Sobirin, Mochamad A.
   Masaki, Yoshihiro
   Mizushima, Wataru
   Kadoguchi, Tomoyasu
   Okita, Koichi
   Tsutsui, Hiroyuki
TI Angiotensin II receptor blocker improves the lowered exercise capacity
   and impaired mitochondrial function of the skeletal muscle in type 2
   diabetic mice
SO JOURNAL OF APPLIED PHYSIOLOGY
LA English
DT Article
DE oxidative stress; angiotensin; diabetes; mitochondria; muscle
ID FRUCTOSE-FED RATS; OXIDATIVE STRESS; INSULIN-RESISTANCE; NAD(P)H
   OXIDASE; ADIPOSE-TISSUE; HEART-FAILURE; METABOLIC SYNDROME; REDOX STATE;
   CELLS; RESPIRATION
AB Angiotensin II receptor blocker improves the lowered exercise capacity and impaired mitochondrial function of the skeletal muscle in type 2 diabetic mice. J Appl Physiol 114: 844-857, 2013. First published January 17, 2013; doi:10.1152/japplphysiol.00053.2012.-NAD(P)H oxidase-induced oxidative stress is at least in part involved with lowered exercise capacity and impaired mitochondrial function in high-fat diet (HFD)-induced diabetic mice. NAD(P)H oxidase can be activated by activation of the renin-angiotensin system. We investigated whether ANG II receptor blocker can improve exercise capacity in diabetic mice. C57BL/6J mice were fed a normal diet (ND) or HFD, and each group of mice was divided into two groups: treatment with or without olmesartan (OLM; 3 mg.kg(-1).day(-1) in the drinking water). The following groups of mice were studied: ND, ND+OLM, HFD, and HFD+OLM (n = 10 for each group). After 8 wk, HFD significantly increased body weight, plasma glucose, and insulin compared with ND, and OLM did not affect these parameters in either group. Exercise capacity, as determined by treadmill tests, was significantly reduced in HFD, and this reduction was ameliorated in HFD+OLM. ADP-dependent mitochondrial respiration was significantly decreased, and NAD(P)H oxidase activity and superoxide production by lucigenin chemiluminescence were significantly increased in skeletal muscle from HFD, which were attenuated by OLM. There were no such effects by OLM in ND. We concluded that OLM ameliorated the decrease in exercise capacity in diabetic mice via improvement in mitochondrial function and attenuation of oxidative stress in skeletal muscle. These data may have a clinical impact on exercise capacity in the medical treatment of diabetes mellitus.
C1 [Takada, Shingo; Kinugawa, Shintaro; Hirabayashi, Kagami; Suga, Tadashi; Yokota, Takashi; Takahashi, Masashige; Fukushima, Arata; Homma, Tsuneaki; Ono, Taisuke; Masaki, Yoshihiro; Mizushima, Wataru; Kadoguchi, Tomoyasu; Tsutsui, Hiroyuki] Hokkaido Univ, Grad Sch Med, Dept Cardiovasc Med, Sapporo, Hokkaido 0608638, Japan.
   [Takada, Shingo; Suga, Tadashi] Japan Soc Promot Sci, Tokyo, Japan.
   [Sobirin, Mochamad A.] Diponegoro Univ, Fac Med, Semarang, Indonesia.
   [Okita, Koichi] Hokusho Univ, Grad Sch Program Lifelong Learning Studies, Ebetsu, Hokkaido, Japan.
C3 Hokkaido University; Japan Society for the Promotion of Science;
   Diponegoro University
RP Kinugawa, S (corresponding author), Hokkaido Univ, Grad Sch Med, Dept Cardiovasc Med, Kita Ku, Kita 15,Nishi 7, Sapporo, Hokkaido 0608638, Japan.
EM tuckahoe@med.hokudai.ac.jp
RI Kinugawa, Shintaro/E-1268-2012
OI Kadoguchi, Tomoyasu/0000-0001-6336-5160; sobirin, mochamad
   ali/0000-0001-9558-4966
FU Ministry of Education, Science, and Culture [20117004, 21390236,
   20590854]; Daiichi Sankyo Co. Ltd., Japan; Grants-in-Aid for Scientific
   Research [23500784, 25882041, 20590854, 20117004, 21390236] Funding
   Source: KAKEN
FX This study was supported by grants from the Ministry of Education,
   Science, and Culture (20117004, 21390236, 20590854) and from Daiichi
   Sankyo Co. Ltd., Japan.
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NR 43
TC 38
Z9 39
U1 0
U2 11
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 8750-7587
EI 1522-1601
J9 J APPL PHYSIOL
JI J. Appl. Physiol.
PD APR
PY 2013
VL 114
IS 7
BP 844
EP 857
DI 10.1152/japplphysiol.00053.2012
PG 14
WC Physiology; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology; Sport Sciences
GA 118CV
UT WOS:000317001000003
PM 23329824
DA 2025-06-11
ER

PT J
AU Jeyapal, S
   Putcha, UK
   Mullapudi, VS
   Ghosh, S
   Sakamuri, A
   Kona, SR
   Vadakattu, SS
   Madakasira, C
   Ibrahim, A
AF Jeyapal, Sugeedha
   Putcha, Uday Kumar
   Mullapudi, Venkata Surekha
   Ghosh, Sudip
   Sakamuri, Anil
   Kona, Suryam Reddy
   Vadakattu, Sai Santosh
   Madakasira, Chandana
   Ibrahim, Ahamed
TI Chronic consumption of fructose in combination with trans fatty
   acids but not with saturated fatty acids induces nonalcoholic
   steatohepatitis with fibrosis in rats
SO EUROPEAN JOURNAL OF NUTRITION
LA English
DT Article
DE Western diet; High fructose; High fat; Saturated fatty acids; Trans
   fatty acids; Inflammation; Oxidative stress; Gene expression;
   Nonalcoholic fatty liver disease; Nonalcoholic steatohepatitis; Fibrosis
ID COA DESATURASE 1; LIVER-DISEASE; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   HEPATIC STEATOSIS; OXIDATIVE STRESS; LIPID-METABOLISM; GENE-EXPRESSION;
   SEVERE NAFLD; DIET
AB Purpose Consumption of Western diet high in fat and fructose has been attributed to the recent epidemic of nonalcoholic fatty liver disease (NAFLD). However, the impact of specific fatty acids on the progression of NAFLD to nonalcoholic steatohepatitis (NASH) is poorly understood. In the present study, we investigated the chronic effects of consumption of fructose in combination with saturated fatty acids (SFA) or trans fatty acids (TFA) on the development of NAFLD.
   Methods Male Sprague-Dawley rats were randomly assigned to six isocaloric starch/high fructose (44% of calories), high fat (39% calories) diet containing either starch-peanut oil, fructose-peanut oil, fructose-palmolein, fructose-clarified butter, fructose-coconut oil or fructose-partially hydrogenated vegetable oil and fed for 24 weeks. Palmolein, clarified butter and coconut oil were used as the source of SFA whereas partially hydrogenated vegetable oil was used as the source of TFA. Peanut oil was used as the reference oil.
   Results Long-term feeding of fructose in combination with SFA or TFA induced hepatic steatosis of similar extent associated with upregulation of stearoyl CoA desaturase-1. In contrast, fructose in combination with TFA induced NASH with fibrosis as evidenced by upregulation of hepatic proinflammatory cytokine and fibrogenic gene expression, increased hepatic oxidative stress and adipocytokine imbalance. Histopathological analysis revealed the presence of NASH with fibrosis. Further, peanut oil prevented the development of NAFLD in fructose-fed rats.
   Conclusion Fructose in combination with TFA caused NASH with fibrosis by inducing oxidative stress and inflammation, whereas, fructose in combination with SFA caused simple steatosis, suggesting that the type of fatty acid is more important for the progression of NAFLD.
C1 [Jeyapal, Sugeedha; Sakamuri, Anil; Kona, Suryam Reddy; Vadakattu, Sai Santosh; Madakasira, Chandana; Ibrahim, Ahamed] Natl Inst Nutr, Dept Lipid Chem, Hyderabad, Telangana, India.
   [Putcha, Uday Kumar; Mullapudi, Venkata Surekha] Natl Inst Nutr, Dept Pathol, Hyderabad, Telangana, India.
   [Ghosh, Sudip] Natl Inst Nutr, Dept Mol Biol, Hyderabad, Telangana, India.
C3 Indian Council of Medical Research (ICMR); ICMR - National Institute of
   Nutrition (NIN); Indian Council of Medical Research (ICMR); ICMR -
   National Institute of Nutrition (NIN); Indian Council of Medical
   Research (ICMR); ICMR - National Institute of Nutrition (NIN)
RP Ibrahim, A (corresponding author), Natl Inst Nutr, Dept Lipid Chem, Hyderabad, Telangana, India.
EM ahamed65@yahoo.co.in
FU Indian Council of Medical Research, Government of India
   [5/4/3-7/TF/2011/NCD-II]; Indian Council of Medical Research, Government
   of India
FX This study was funded by Grants in aid (5/4/3-7/TF/2011/NCD-II) from
   Indian Council of Medical Research, Government of India to AI. JS was
   supported by a fellowship from Indian Council of Medical Research,
   Government of India.
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NR 67
TC 16
Z9 18
U1 0
U2 16
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1436-6207
EI 1436-6215
J9 EUR J NUTR
JI Eur. J. Nutr.
PD SEP
PY 2018
VL 57
IS 6
BP 2171
EP 2187
DI 10.1007/s00394-017-1492-1
PG 17
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA GQ7KL
UT WOS:000441919500013
PM 28676973
DA 2025-06-11
ER

PT J
AU Xiao, L
   Aoshima, H
   Saitoh, Y
   Miwa, N
AF Xiao, Li
   Aoshima, Hisae
   Saitoh, Yasukazu
   Miwa, Nobuhiko
TI Highly hydroxylated fullerene localizes at the cytoskeleton and inhibits
   oxidative stress in adipocytes and a subcutaneous adipose-tissue
   equivalent
SO FREE RADICAL BIOLOGY AND MEDICINE
LA English
DT Article
DE Fullerene; Oxidative stress; Adipose tissue engineering; Inflammation;
   Vimentin; Free radicals
ID KERATINOCYTE CELL-LINE; SCAVENGING ACTIVITY; INSULIN-RESISTANCE;
   OBESITY; C-60(OH)(24); DIFFERENTIATION; CARDIOTOXICITY; ADIPOGENESIS;
   SECRETION; CULTURE
AB Adipose tissue is a crucial site for pathologic changes in obesity/metabolic syndrome-related diseases. Interaction between adipogenesis and reactive oxygen species (ROS) in adipose tissue involving chronic low-grade inflammation is postulated to be causal in the development of insulin resistance and other metabolic consequences. We used different culture systems to investigate the relationship between ROS and adipogenesis at three levels: within adipocytes, during adipocyte monocyte interactions, and in a subcutaneous adipose tissue model. The effects of highly hydroxylated fullerene (HHF: C-60(OH)(36)) on adipogenesis-accompanying oxidative stress and inflammatory changes were examined using these three systems. We demonstrated that H2O2 stimulates lipid accumulation in 3T3-L1 preadipocytes, and lipid uptake causes ROS generation in OP9 preadipocytes, both of which were then markedly suppressed with HHF treatment. HHF significantly inhibited the adipogenic stimulant insulin-rich serum replacement (SR)-induced triacylglycerol accumulation, ROS production, and macrophage activation in cultured OP9 cells and an OP9-U937 monocyte-like cell coculture system. H2O2-induced intracellular ROS production in OP9 adipocytes was also notably inhibited by HHF. We developed a three-dimensional subcutaneous adipose-tissue equivalent (SATE) consisting of air-exposed cultures of HaCaT keratinocytes on an OP9 adipocyte-populated collagen gel in a culture insert. With SR stimulation and under suitable conditions, fat accumulation, ROS generation, and macrophage infiltration were observed in the SATE and significantly inhibited by HHF. By western blotting, we demonstrated that HHF localized at the cytoskeleton, which controls the transport of lipids. In conclusion, HHF is able to inhibit oxidative stress in adipocytes and adipogenesis-related macrophage activation in adipose tissues through its antioxidation. (C) 2011 Elsevier Inc. All rights reserved.
C1 [Xiao, Li; Saitoh, Yasukazu; Miwa, Nobuhiko] Prefectural Univ Hiroshima, Fac Life & Environm Sci, Lab Cell Death Control BioTechnol, Hiroshima 7270023, Japan.
   [Aoshima, Hisae] Vitamin C60 BioRes Corp, Chuo Ku, Tokyo 1030028, Japan.
RP Miwa, N (corresponding author), Prefectural Univ Hiroshima, Fac Life & Environm Sci, Lab Cell Death Control BioTechnol, Hiroshima 7270023, Japan.
EM miwa-nob@pu-hiroshima.ac.jp
RI Xiao, Li/AAX-7766-2020; saitoh, yasukazu/AAQ-6432-2021
OI Saitoh, Yasukazu/0000-0002-6288-7634; Xiao, Li/0000-0002-3053-4930
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NR 42
TC 43
Z9 43
U1 1
U2 31
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0891-5849
EI 1873-4596
J9 FREE RADICAL BIO MED
JI Free Radic. Biol. Med.
PD OCT 1
PY 2011
VL 51
IS 7
BP 1376
EP 1389
DI 10.1016/j.freeradbiomed.2011.05.026
PG 14
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 818GV
UT WOS:000294740700010
PM 21684329
DA 2025-06-11
ER

PT J
AU Al-Wakeel, DE
   El-Kashef, DH
   Nader, MA
AF Al-Wakeel, Dina E.
   El-Kashef, Dalia H.
   Nader, Manar A.
TI Renoprotective effect of empagliflozin in cafeteria diet-induced insulin
   resistance in rats: Modulation of HMGB-1/TLR-4/NF-?B axis
SO LIFE SCIENCES
LA English
DT Article
DE Cafeteria diet; Empagliflozin; Insulin resistance; Oxidative stress;
   Inflammation; Apoptosis
ID METABOLIC SYNDROME; OXIDATIVE STRESS; KIDNEY-DISEASE; TNF-ALPHA;
   INFLAMMATION; METFORMIN; MODEL; DENSITY; OBESITY; PLASMA
AB Aim: Cafeteria diet (CAF) is a well-established model used to mimic what occurs in human upon eating junk and ultra-processed food. This study aimed to investigate the possible protective impact of empagliflozin (EMPA) against CAF-induced insulin resistance (IR) in rats and the possible underlying mechanisms. Main methods: Rats were fed on CAF diet for 12 weeks while treatment with EMPA (10 & 30 mg/kg/day, orally) and/or metformin (MET) (100 mg/kg/day, orally) started at day 29. Key findings: Oral administration of EMPA and/or MET significantly and dose-dependently succeeded to attenuate CAF-induced obesity which was evidenced by decreased oral glucose tolerance test (AUC(OGTT)), insulin tolerance test (AUC(ITT)) and decreased fasting serum insulin level besides improving the histopathological alterations induced by CAF. Moreover, EMPA significantly mitigated CAF-induced elevation in serum levels of creatinine urea, transaminases (ALT and AST), and increased albumin level as well as improving dyslipidemia and oxidative stress. Furthermore, EMPA markedly reduced renal levels of high mobility group box 1 (HMGB-1), toll like receptor4 (TLR-4) and nuclear factor kappa B (NF-kappa B) as well as decreasing the expression of tumor necrosis factor alpha (TNF-alpha) and Caspase 3. Combining EMPA(30) with MET synergistically improved dyslipidemia, oxidative stress and enhanced kidney function. Significance: EMPA administration could confer protection against CAF-induced IR and its complications through its hypoglycemic, insulin-sensitizing, hypolipidemic, hepatoprotective, renoprotective, anti-inflammatory, anti-oxidant and anti-apoptotic properties. Also, our findings highlighted the synergistic effect of combining EMPA(30) with MET so this combination might be promising in treatment of IR.
C1 [Al-Wakeel, Dina E.; El-Kashef, Dalia H.; Nader, Manar A.] Mansoura Univ, Fac Pharm, Dept Pharmacol & Toxicol, Mansoura, Egypt.
C3 Egyptian Knowledge Bank (EKB); Mansoura University
RP El-Kashef, DH (corresponding author), Mansoura Univ, Fac Pharm, Dept Pharmacol & Toxicol, Mansoura, Egypt.
EM dalia_ekashef@mans.edu.eg
RI El-Kashef, Dalia/AAW-5026-2020
OI El-Kashef, Dalia/0000-0002-0021-5533
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NR 48
TC 9
Z9 9
U1 1
U2 1
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0024-3205
EI 1879-0631
J9 LIFE SCI
JI Life Sci.
PD JUL 15
PY 2022
VL 301
AR 120633
DI 10.1016/j.lfs.2022.120633
EA MAY 2022
PG 14
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA 1W5SL
UT WOS:000806833200007
PM 35568226
DA 2025-06-11
ER

PT J
AU Askari, G
   Aghajani, M
   Salehi, M
   Najafgholizadeh, A
   Keshavarzpour, Z
   Fadel, A
   Venkatakrishnan, K
   Salehi-sahlabadi, A
   Hadi, A
   Pourmasoumi, M
AF Askari, Gholamreza
   Aghajani, Mobina
   Salehi, Mina
   Najafgholizadeh, Ameneh
   Keshavarzpour, Ziyaadin
   Fadel, Abdulmannan
   Venkatakrishnan, Kamesh
   Salehi-sahlabadi, Ammar
   Hadi, Amir
   Pourmasoumi, Makan
TI The effects of ginger supplementation on biomarkers of inflammation and
   oxidative stress in adults: A systematic review and meta-analysis of
   randomized controlled trials
SO JOURNAL OF HERBAL MEDICINE
LA English
DT Review
DE Ginger; Supplementation; Inflammation; Oxidative stress; Meta-analysis
ID CARDIOVASCULAR RISK-FACTORS; ZINGIBER-OFFICINALE-ROSCOE; C-REACTIVE
   PROTEIN; METABOLIC SYNDROME; LIPID PROFILE; CYTOKINES; MARKERS;
   LIPOPOLYSACCHARIDE; INTERLEUKIN-6; ASSOCIATION
AB The current systematic review and meta-analysis of randomized controlled trials (RTCs) was conducted to summarize the effect of ginger supplementation on biomarkers of inflammation and oxidative stress in adults. Electronic databases including PubMed, Scopus, Web of Science, Cochrane Library and Google Scholar were systematically searched up to February 2018 to identify eligible RCTs which assessed the effect of ginger on C-reactive protein (CRP), interleukin-6 (IL-6) tumor necrosis factor (TNF-alpha), total antioxidant capacity (TAC) and lipid peroxidation products like malondialdehyde (MDA). Fourteen studies were eligible to be included in the quantitative analysis. Results from meta-analysis suggested that CRP (-0.8 mg/L, 95 % CI: -1.17 to -0.43; I-2 = 53 %), IL-6 (-2.26 pg/mL; 95 % CI: -4.00 to -0.52; I-2 = 58 %) and TNF-alpha (-1.33 pg/mL; 95 % CI: -1.85 to -0.80; I-2 = 55%) were significantly reduced by ginger supplementation. The pooled effect size indicated a significant increase in blood TAC levels after ginger consumption (1.26 mu mol/L; 95 % CI: 0.17-2.35; I-2 = 84%). Ginger had no significant effect on MDA (-0.29 mu mol/L; 95 % CI: -1.06 to 0.47; I-2 = 78%). Subgroup analysis showed that the effect of ginger on CRP and TNF-alpha is more pronounced in studies with > 80-days' intervention. When studies were categorized based on hs-CRP/CRP, the effect of ginger was significant in both subgroups. In conclusion, the present study suggested that supplementation with ginger can improve health status in adults by lowering inflammatory and oxidative stress markers. Future trials with high methodological quality are needed to support the beneficial potential (anti-inflammatory and antioxidant effects) of ginger.
C1 [Askari, Gholamreza; Salehi, Mina; Pourmasoumi, Makan] Isfahan Univ Med Sci, Food Secur Res Ctr, Sch Nutr & Food Sci, POB 73461-81746, Esfahan, Iran.
   [Askari, Gholamreza; Salehi, Mina; Pourmasoumi, Makan] Isfahan Univ Med Sci, Dept Community Nutr, Sch Nutr & Food Sci, POB 73461-81746, Esfahan, Iran.
   [Aghajani, Mobina] Iran Univ Med Sci, Gastrointestinal & Liver Dis Res Ctr, Tehran, Iran.
   [Najafgholizadeh, Ameneh] Islamic Azad Univ, Dept Microbiol, Naein Branch, Esfahan, Iran.
   [Keshavarzpour, Ziyaadin] Bushehr Univ Med Sci, Fac Hlth & Nutr, Bushehr, Iran.
   [Fadel, Abdulmannan] Liverpool John Moores Univ, Sch Sport & Exercise Sci, Fac Sci, Liverpool, Merseyside, England.
   [Venkatakrishnan, Kamesh] Chung Shan Med Univ, Sch Nutr, Taichung, Taiwan.
   [Salehi-sahlabadi, Ammar] Shahid Beheshti Univ Med Sci, Student Res Comm, Dept Clin Nutr & Dietet, Fac Nutr & Food Technol, Tehran, Iran.
   [Hadi, Amir] FDA, Halal Res Ctr IRI, POB 81745, Tehran, Iran.
   [Pourmasoumi, Makan] Universal Sci Educ & Res Network USERN, Tehran, Iran.
C3 Isfahan University of Medical Sciences; Isfahan University of Medical
   Sciences; Iran University of Medical Sciences; Islamic Azad University;
   Liverpool John Moores University; Chung Shan Medical University; Shahid
   Beheshti University Medical Sciences; Universal Scientific Education &
   Research Network (USERN)
RP Pourmasoumi, M (corresponding author), Isfahan Univ Med Sci, Food Secur Res Ctr, Sch Nutr & Food Sci, POB 73461-81746, Esfahan, Iran.; Pourmasoumi, M (corresponding author), Isfahan Univ Med Sci, Dept Community Nutr, Sch Nutr & Food Sci, POB 73461-81746, Esfahan, Iran.; Hadi, A (corresponding author), FDA, Halal Res Ctr IRI, POB 81745, Tehran, Iran.
EM amirhadi.vnt@gmail.com; Makan.pourmasoumi@gmail.com
RI askari, gholamreza/M-9362-2016; Pourmasoumi, Makan/J-6861-2019; Hadi,
   Amir/AAK-4634-2020; salehi-sahlabadi, ammar/KHD-7718-2024; Fadel,
   Abdulmannan/AAS-8620-2021; Salehi, Mina/LPR-0529-2024
OI Pourmasoumi, Makan/0000-0001-9335-7276; Fadel,
   Abdulmannan/0000-0001-6042-8939
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NR 64
TC 12
Z9 13
U1 3
U2 20
PU ELSEVIER GMBH
PI MUNICH
PA HACKERBRUCKE 6, 80335 MUNICH, GERMANY
SN 2210-8033
EI 2210-8041
J9 J HERB MED
JI J. Herb. Med.
PD AUG
PY 2020
VL 22
AR 100364
DI 10.1016/j.hermed.2020.100364
PG 9
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA MN3RB
UT WOS:000550760600001
DA 2025-06-11
ER

PT J
AU Chauhan, SMP
   Chauhan, P
   Subramani, SK
   Anand, A
   Borole, D
   Goswamy, H
   Prasad, GBKS
AF Mahajan, Sunil
   Chauhan, Pratibha
   Subramani, Senthil Kumar
   Anand, Ashwinee
   Borole, Dinesh
   Goswamy, Harimohan
   Prasad, G. B. K. S.
TI Evaluation of "GSPF kwath": A Gymnema
   sylvestre-containing polyherbal formulation for the treatment of
   human type 2 diabetes mellitus
SO EUROPEAN JOURNAL OF INTEGRATIVE MEDICINE
LA English
DT Article
DE Antidiabetic; Antihyperlipidemic; Blood glucose; Oxidative stress;
   Polyherbal formulation; Type 2 diabetes mellitus
ID PTEROCARPUS-MARSUPIUM ROXB.; ANTIDIABETIC ACTIVITY; EMBLICA-OFFICINALIS;
   METABOLIC SYNDROME; SWERTIA CHIRAYITA; OXIDATIVE STRESS; IN-VITRO;
   EXTRACT; ACID; RATS
AB Introduction: Since ancient times, plant-based herbal formulations have been used in Indian traditional medicine to treat diabetes. This observational study investigated the antihyperglycemic, antihyperlipidemic, and antioxidant potential of a Gymnema sylvestre polyherbal formulation ("GSPF kwath") in patients with type 2 diabetes mellitus.
   Methods: A before-and-after study of 32 human subjects with type 2 diabetes mellitus was carried out. Patients were administered "GSPF kwath" consisting of a mixture of 10 herbs: G. sylvestre (gurmar), Syzygium cumini (jamun seed), Phyllanthus emblica (amla), Curcuma longa (haldi), Pterocarpus marsupium (vijaysaar), Terminalia chebula (harad), Cassia fistula (amaltas), Picrorhiza kurroa (kutki), Swertia chirata (chirayita), and Terminalia bellirica (behada). Patients were administered 50 ml of aqueous extract derived from 10 g of "GSPF kwath" daily on an empty stomach for 6 months. The blood glucose levels were monitored monthly, and glycosylated hemoglobin, lipid profile and biomarkers of oxidative stress, and liver and kidney function markers were measured at 3-monthly intervals.
   Results: Daily administration of "GSPF kwath" regularly for 6 months resulted in significant reductions of blood glucose and glycosylated hemoglobin levels. There was also a significant increase in high-density lipoprotein cholesterol levels and concomitant decreases in total cholesterol, triglyceride, low-density lipoprotein cholesterol, and very-low-density lipoprotein levels. Patients exhibited a significant improvement in the biochemical markers for oxidative stress.
   Conclusions: The results suggest that the polyherbal formulation GSPF may have the potential to regulate both hyperglycemia and possibly hyperlipidemia. "GSPF kwath" may be a potentially safe and effective therapy for the treatment of type 2 diabetes mellitus. (C) 2015 Elsevier GmbH. All rights reserved.
C1 [Mahajan, Sunil; Chauhan, Pratibha; Subramani, Senthil Kumar; Anand, Ashwinee; Borole, Dinesh; Goswamy, Harimohan; Prasad, G. B. K. S.] Jiwaji Univ, Sch Studies Biochem, Gwalior 474011, India.
C3 Jiwaji University Gwalior
RP Prasad, GBKS (corresponding author), Jiwaji Univ, Sch Studies Biochem, Gwalior 474011, India.
EM mahajansunil1984@gmail.com; chauhanpra17@gmail.com; sskbio.03@gmail.com;
   ashwineeanand@rediffmail.com; dineshborole@gmail.com;
   hmgoswamy@gmail.com; gbksprasad@gmail.com
RI KUMAR, SUNIL/ABG-7529-2022; Borole, Dinesh/AAE-2191-2019
OI subramani, senthilkumar/0000-0001-5603-3002
FU AYUSH, New Delhi [Z.31014/02/2009/EMR-CCARS]
FX We thank Deendayal Aushadhi Pvt. Ltd., Gwalior (M.P.), for supplying the
   polyherbal formulation, and the financial support from AYUSH, New Delhi
   (F.NO. Z.31014/02/2009/EMR-CCARS), is duly acknowledged. We are grateful
   to all the human subjects who volunteered to participate in the study.
   We are extremely grateful to our colleagues in the laboratory and
   students for their unreserved support in conducting this study.
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NR 54
TC 14
Z9 15
U1 0
U2 21
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1876-3820
EI 1876-3839
J9 EUR J INTEGR MED
JI Eur. J. Integr. Med.
PD MAY
PY 2015
VL 7
IS 3
BP 303
EP 311
DI 10.1016/j.eujim.2015.01.003
PG 9
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA CK0WG
UT WOS:000355925500015
DA 2025-06-11
ER

PT J
AU Zhu, W
   Chen, SF
   Li, ZL
   Zhao, XH
   Li, WX
   Sun, YS
   Zhang, ZL
   Ling, WH
   Feng, X
AF Zhu, Wei
   Chen, Sifan
   Li, Zilun
   Zhao, Xiaohong
   Li, Wenxue
   Sun, Yanshuang
   Zhang, Zili
   Ling, Wenhua
   Feng, Xiang
TI Effects and mechanisms of resveratrol on the amelioration of oxidative
   stress and hepatic steatosis in KKAy mice
SO NUTRITION & METABOLISM
LA English
DT Article
DE NAFLD; Lipid metabolic disorder; Oxidative stress; Resveratrol; Sirt1;
   AMPK
ID NONALCOHOLIC FATTY LIVER; ACTIVATED PROTEIN-KINASE; ADIPOSE TRIGLYCERIDE
   LIPASE; INSULIN SENSITIVITY; METABOLIC SYNDROME; LIPID-METABOLISM;
   RODENT MODEL; DNA-DAMAGE; SIRT1; DISEASE
AB Background: The exact mechanism of the protective role of Resveratrol (Res) in lipid metabolism and oxidative stress is not well elucidated. The present study aimed to investigate the potential benefits and possible mechanisms of Res on the amelioration of oxidative stress and hepatic steatosis in a KKAy mouse model.
   Methods: A total of 30 KKAy male mice were randomly divided into three groups: a normal chow group, a low resveratrol group and a high resveratrol group. After a 12-wk study period, serum levels of TG, TC, LDL-C and HDL-C, the liver content of TG and TC, ROS, GSH, GPx, SOD and MDA levels were measured. Ectopic lipid deposition was observed in sectioned frozen liver tissues. The mRNA levels of ATGL and HSL in the liver tissues were determined via real-time PCR. Furthermore, the protein expression of p47phox, gp91phox, ATGL, HSL, Sirt1, AMPK and FOXO1 were analyzed using western blotting.
   Results: Following Res supplementation, serum levels of TG and MDA were decreased, while the HDL-C and SOD levels were increased in KKAy mice. Furthermore, Res treatment increased GSH and GPx in liver tissues, while it decreased ROS. In addition, Res significantly reduced hepatic steatosis. After Res treatment, concentrations of p47phox (membrane) and gp91phox proteins were reduced, while p-HSL, HSL and ATGL protein expression levels were increased. Mechanistically, the levels of Sirt1, p-AMPK and p-FOXO1 expression in the liver tissues were up-regulated following supplementation with Res, and FOXO1 protein was released from the nucleus into the cytoplasm.
   Conclusions: Res is able to attenuate hepatic steatosis and lipid metabolic disorder and enhance the antioxidant ability in KKAy mice, possibly by up-regulating Sirt1 expression and the phosphorylation of AMPK.
C1 [Chen, Sifan; Sun, Yanshuang; Zhang, Zili; Ling, Wenhua; Feng, Xiang] Sun Yat Sen Univ, Sch Publ Hlth, Guangzhou 510275, Guangdong, Peoples R China.
   [Chen, Sifan; Sun, Yanshuang; Zhang, Zili; Ling, Wenhua; Feng, Xiang] Guangdong Prov Key Lab Food Nutr & Hlth, Guangzhou, Guangdong, Peoples R China.
   [Zhu, Wei; Chen, Sifan; Li, Wenxue] Guangzhou Ctr Dis Control & Prevent, Guangzhou, Guangdong, Peoples R China.
   [Li, Zilun] Sun Yat Sen Univ, Affiliated Hosp 1, Div Vasc Surg, Guangzhou 510275, Guangdong, Peoples R China.
   [Zhao, Xiaohong] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Nephrol, Guangzhou 510275, Guangdong, Peoples R China.
C3 Sun Yat Sen University; Sun Yat Sen University; Sun Yat Sen University
RP Zhu, W (corresponding author), Guangzhou Ctr Dis Control & Prevent, Guangzhou, Guangdong, Peoples R China.
EM zhuyc126@126.com; fengx@mail.sysu.edu.cn
RI zili, zhang/ABE-8373-2021; li, wenxue/K-7505-2014
OI li, wenxue/0000-0002-0346-5300
FU Guangdong Provincial Department of Science and Technology
   [2012B060300005]; National Natural Science Foundation of Guangdong
   Provincial [S2012010009633]; National Natural Science Foundation of
   China [81101562, 81172462]; Key Project of Guangzhou Medical and Health
   Science and Technology [20121A021018]; Key Medicine Discipline
   Construction of Guangzhou Municipality [2013-2015-07]; Guangdong
   Provincial Research Grants for Medical Research [A2013176];
   Administration of Traditional Chinese Medicine of Guangdong Province
   [20111157]
FX This work was supported by grants from: 1. The Guangdong Provincial
   Department of Science and Technology (2012B060300005); 2. The National
   Natural Science Foundation of Guangdong Provincial (S2012010009633); 3.
   The National Natural Science Foundation of China (81101562 and
   81172462); 4. Key Project of Guangzhou Medical and Health Science and
   Technology (20121A021018); 5. The Project for Key Medicine Discipline
   Construction of Guangzhou Municipality (2013-2015-07); 6. Guangdong
   Provincial Research Grants for Medical Research (A2013176); 7. Project
   of Administration of Traditional Chinese Medicine of Guangdong Province
   (No. 20111157). The funders had no role in study design, data collection
   and analysis, decision to publish, or preparation of the manuscript.
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NR 38
TC 82
Z9 91
U1 2
U2 48
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1743-7075
J9 NUTR METAB
JI Nutr. Metab.
PD AUG 12
PY 2014
VL 11
AR 35
DI 10.1186/1743-7075-11-35
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA AN9UA
UT WOS:000340953100001
PM 25140191
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Demir, B
   Çaglar, IM
   Türeli, HO
   Özde, C
   Açiksari, G
   Çiftçi, S
   Üngan, I
   Demir, E
   Karakaya, O
   Özyazgan, S
AF Demir, Bulent
   Caglar, Ilker Murat
   Tureli, Hande Oktay
   Ozde, Cem
   Aciksari, Gonul
   Ciftci, Serkan
   Ungan, Ismail
   Demir, Esra
   Karakaya, Osman
   Ozyazgan, Sibel
TI Elevated serum gamma-glutamyltransferase levels in patients with dilated
   ascending aorta
SO ANATOLIAN JOURNAL OF CARDIOLOGY
LA English
DT Article
DE aortic aneurysm; gamma-glutamyltransferase; oxidative stress;
   hypertension; regression analysis; sensitivity; specificity
ID OXIDATIVE STRESS; CARDIOVASCULAR-DISEASE; URIC-ACID; METABOLIC SYNDROME;
   HYDROGEN-PEROXIDE; ANEURYSMS; ECHOCARDIOGRAPHY; ATHEROSCLEROSIS;
   RECOMMENDATIONS; HYPERTENSION
AB Objective: This study aimed to evaluate the serum gamma-glutamyltransferase (GGT) levels as an indirect marker of elevated oxidative stress in patients with dilated ascending aorta.
   Methods: The study was designed as an observational cross-sectional controlled study. One hundred consecutive patients with dilated ascending aorta and 50 consecutive controls with normal ascending aorta diameter were selected for the study by comprehensive transthoracic echocardiography (TTE). The aortic dilatation group was divided into two subgroups, according to the literature as the ectasia group (3.8-4.3 cm, 53 patients, 24 male and 29 female, mean age: 62.9 +/- 10.9 years) and the aneurysm group (>= 4.4 cm, 47 patients, 18 male and 29 female, mean age: 65.5 +/- 11.1 years). The control group consisted of patients demonstrating no ascending aorta dilatation (<= 3.7 cm, 50 patients, 24 male and 26 female, mean age: 62.7 +/- 9.2 years). ANOVA, Mann-Whitney U test, Pearson's correlation analysis, multivariate logistic regression analysis, and receiver-operator curve analysis were used for statistical analysis.
   Results: Regarding the comparison of laboratory parameters between the patient and control groups, serum gamma-glutamyltransferase (GGT) levels were found to be statistically significantly higher in both of the aortic dilatation subgroups than in the control group (p<0.001). In the correlation analysis between the ascending aorta diameter and GGT, a statistically significant positive correlation was found (r=0.282, p<0.001). The multivariate regression analysis revealed a significant relationship between GGT and the proximal ascending aorta diameter (beta=0.131, odds ratio: 1.140, 95% CI: 1.060-1.225, p<0.001).
   Conclusion: GGT as a marker of oxidative stress may play a role in the pathogenesis of aneurysm of the ascending aorta.
C1 [Demir, Bulent; Caglar, Ilker Murat; Tureli, Hande Oktay; Ozde, Cem; Aciksari, Gonul; Ciftci, Serkan; Ungan, Ismail; Karakaya, Osman] Bakirkoy Dr Sadi Konuk Educ & Res Hosp, Clin Cardiol, Istanbul, Turkey.
   [Demir, Esra] Bakirkoy Dr Sadi Konuk Educ & Res Hosp, Clin Internal Med, Istanbul, Turkey.
   [Ozyazgan, Sibel] Istanbul Univ, Dept Med Pharmacol, Cerrahpasa Fac Med, Istanbul, Turkey.
C3 Bakirkoy Dr. Sadi Konuk Research & Training Hospital; Bakirkoy Dr. Sadi
   Konuk Research & Training Hospital; Istanbul University - Cerrahpasa;
   Istanbul University
RP Demir, B (corresponding author), Atakoy 9 Kisim,Hanimeli Cicegi Sokak,B-28 Blok, TR-34156 Istanbul, Turkey.
EM drbdmr06@hotmail.com
RI Karakaya, Osman/KPB-5126-2024; Özyazgan, Sibel/C-7404-2019; aciksari,
   gonul/LXW-1995-2024; Demir, Bulent/KVC-1688-2024; özde,
   cem/AAQ-6996-2020
OI Aciksari, Gonul/0000-0002-8380-3065; Demir, Bulent/0000-0003-1767-408X;
   Ozyazgan, Sibel/0000-0002-2511-3541; Ciftci, Serkan/0000-0002-0948-9936
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NR 45
TC 4
Z9 4
U1 0
U2 6
PU TURKISH SOC CARDIOLOGY
PI BAHCELIEVLER
PA COBANCESME SANAYI CAD NO 11, NISH ISTANBUL A BLOK KAT 8 NO 47-48,
   YENIBOSNA, BAHCELIEVLER, ISTANBUL 34196, TURKEY
SN 2149-2263
EI 2149-2271
J9 ANATOL J CARDIOL
JI Anat. J. Cardiol.
PD MAR
PY 2014
VL 14
IS 2
BP 106
EP 114
DI 10.5152/akd.2014.4646
PG 9
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA AK0ML
UT WOS:000338107100004
PM 24449621
DA 2025-06-11
ER

PT J
AU Geeraert, B
   Crombé, F
   Hulsmans, M
   Benhabilès, N
   Geuns, JM
   Holvoet, P
AF Geeraert, B.
   Crombe, F.
   Hulsmans, M.
   Benhabiles, N.
   Geuns, J. M.
   Holvoet, P.
TI Stevioside inhibits atherosclerosis by improving insulin signaling and
   antioxidant defense in obese insulin-resistant mice
SO INTERNATIONAL JOURNAL OF OBESITY
LA English
DT Article
DE atherosclerosis; oxidative stress; insulin signaling; natural sweetener
ID LOW-DENSITY-LIPOPROTEIN; METABOLIC SYNDROME; OXIDIZED LDL; OXIDATIVE
   STRESS; RECEPTOR SUBSTRATE-1; DYSLIPIDEMIC MICE; DIABETIC-PATIENTS;
   BROWN ADIPOCYTES; DOWN-REGULATION; ANGIOTENSIN-II
AB Objective: Stevioside is a non-caloric natural sweetener that does not induce a glycemic response, making it attractive as sweetener to diabetics and others on carbohydrate-controlled diets. Obesity is frequently associated with insulin resistance and increased inflammation and oxidative stress. Therefore, we investigated its effects on insulin resistance, inflammation and oxidative stress related to atherosclerosis in obese insulin-resistant mice.
   Research design: Twelve-week-old mice were treated with stevioside (10 mg kg(-1), n = 14) or placebo (n = 20) for 12 weeks.
   Results: Stevioside had no effect on weight and triglycerides, but lowered glucose and insulin. Stevioside treatment improved adipose tissue maturation, and increased glucose transport, insulin signaling and antioxidant defense in white visceral adipose tissues. Together, these increases were associated with a twofold increase of adiponectin. In addition, stevioside reduced plaque volume in the aortic arch by decreasing the macrophage, lipid and oxidized low-density lipoprotein (ox-LDL) content of the plaque. The higher smooth muscle cell-to-macrophage ratio was indicative for a more stable plaque phenotype. The decrease in ox-LDL in the plaque was likely due to an increase in the antioxidant defense in the vascular wall, as evidenced by increased Sod1, Sod2 and Sod3. Circulating adiponectin was associated with improved insulin signaling and antioxidant defense in both the adipose tissue and the aorta of stevioside-treated mice.
   Conclusion: Stevioside treatment was associated with improved insulin signaling and antioxidant defense in both the adipose tissue and the vascular wall, leading to inhibition of atherosclerotic plaque development and inducing plaque stabilization. International Journal of Obesity (2010) 34, 569-577; doi: 10.1038/ijo.2009.261; published online 15 December 2009
C1 [Geeraert, B.; Crombe, F.; Hulsmans, M.; Benhabiles, N.; Holvoet, P.] Katholieke Univ Leuven, Atherosclerosis & Metab Unit, Dept Cardiovasc Dis, B-3000 Louvain, Belgium.
   [Geeraert, B.; Crombe, F.; Hulsmans, M.; Benhabiles, N.; Holvoet, P.] Katholieke Univ Leuven, Leuven Food Sci & Nutr Res Ctr, B-3000 Louvain, Belgium.
   [Geuns, J. M.] Katholieke Univ Leuven, Lab Funct Biol, Louvain, Belgium.
C3 KU Leuven; KU Leuven; KU Leuven
RP Holvoet, P (corresponding author), Katholieke Univ Leuven, Atherosclerosis & Metab Unit, Dept Cardiovasc Dis, Herestr 49,O&N1,PB 705, B-3000 Louvain, Belgium.
EM paul.holvoet@med.kuleuven.be
RI Hulsmans, Maarten/AAI-9547-2020; HOLVOET, PAUL/T-8434-2017
OI Hulsmans, Maarten/0000-0003-1009-658X; Holvoet, Paul/0000-0001-9201-0772
FU Fonds voor Wetenschappelijk Onderzoek-Vlaanderen [G. 0548.08]; OT/06/56
   program; Interuniversity Attraction Poles Program - Belgian Science
   Policy [P6/30]
FX This study was supported in part by the Fonds voor Wetenschappelijk
   Onderzoek-Vlaanderen (Program G. 0548.08), the OT/06/56 program and
   Interuniversity Attraction Poles Program - Belgian Science Policy
   (P6/30). We thank Hilde Bernar, Michele Landeloos and Roxane Menten for
   excellent technical assistance.
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NR 40
TC 63
Z9 71
U1 0
U2 24
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0307-0565
EI 1476-5497
J9 INT J OBESITY
JI Int. J. Obes.
PD MAR
PY 2010
VL 34
IS 3
BP 569
EP 577
DI 10.1038/ijo.2009.261
PG 9
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 568DV
UT WOS:000275503200018
PM 20010904
DA 2025-06-11
ER

PT J
AU Musolino, V
   Gliozzi, M
   Nucera, S
   Carresi, C
   Maiuolo, J
   Mollace, R
   Paone, S
   Bosco, F
   Scarano, F
   Scicchitano, M
   Ruga, S
   Zito, MC
   Colica, C
   Macrì, R
   Palma, E
   Ragusa, S
   Muscoli, C
   Mollace, V
AF Musolino, Vincenzo
   Gliozzi, Micaela
   Nucera, Saverio
   Carresi, Cristina
   Maiuolo, Jessica
   Mollace, Rocco
   Paone, Sara
   Bosco, Francesca
   Scarano, Federica
   Scicchitano, Miriam
   Ruga, Stefano
   Zito, Maria Caterina
   Colica, Carmen
   Macri, Roberta
   Palma, Ernesto
   Ragusa, Salvatore
   Muscoli, Carolina
   Mollace, Vincenzo
TI The effect of bergamot polyphenolic fraction on lipid transfer protein
   system and vascular oxidative stress in a rat model of hyperlipemia
SO LIPIDS IN HEALTH AND DISEASE
LA English
DT Article
DE Bergamot polyphenolic fraction; Lipid transfer protein system;
   Hyperlipidaemia; Oxidative stress
ID CHOLESTEROL; INHIBITOR
AB BackgroundExperimental and epidemiological studies show that bergamot polyphenolic fraction (BPF) ameliorates the serum lipemic profile, normalizes blood pressure and improves non alcoholic fatty liver disease in patients suffering from metabolic syndrome. Despite this evidence, the molecular mechanisms responsible for these beneficial effects remain unclear. The aim of our study is to clarify the effects of BPF on the lipoprotein assembly and to identify oxidative stress biomarkers correlating hyperlipidaemia and BPF-induced metabolic changes.MethodsMale Wistar rats (180-200g) were randomly assigned to receive a standard diet, a hypercholesterolemic diet or a hypercholesterolemic diet+BPF (20mg/Kg/rat daily, gavage), respectively, for 90days. Total cholesterol (tChol), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), triglycerides (TG) and fasting plasma glucose were evaluated at the baseline as well as at the end of the treatment. To assess the effect of BPF on the Lipid Transfer Protein System, detection of ACAT, LCAT, CETP, PON1, Apo A1 and Apo B have also been carried out. Finally, the lipid peroxidation biomarker (TBARS) and oxyLDL were also measured.ResultsBPF prevented tChol, LDL-C, TG and fasting plasma glucose enhancement and improved HDL-C. Treatment of hyperlipaemic rats with BPF significantly restored altered the serum concentration of lipemic biomarkers and the activity of ACAT, LCAT, CETP and PON1, an effect accompanied by the concomitant normalization of Apo A1 and APO B levels. In addition, TBARS levels were reduced significantly by the treatment with BPF.ConclusionsBPF prevents diet-induced alteration of the lipid profile in rats, counteracting oxidative stress and improving the dysregulation of the Lipid Transfer Protein System. These data add new insights into the molecular mechanisms underlying the beneficial role of BPF in the therapy of hyperlipidaemia, thus suggesting a novel approach in the prevention of cardiovascular disease.
C1 [Musolino, Vincenzo; Gliozzi, Micaela; Nucera, Saverio; Carresi, Cristina; Maiuolo, Jessica; Mollace, Rocco; Paone, Sara; Bosco, Francesca; Scarano, Federica; Scicchitano, Miriam; Ruga, Stefano; Zito, Maria Caterina; Colica, Carmen; Macri, Roberta; Palma, Ernesto; Muscoli, Carolina; Mollace, Vincenzo] Magna Graecia Univ Catanzaro, Dept Hlth Sci, Inst Res Food Safety & Hlth IRC FSH, Viale Europa, I-88100 Catanzaro, Italy.
   [Musolino, Vincenzo; Gliozzi, Micaela; Nucera, Saverio; Carresi, Cristina; Maiuolo, Jessica; Mollace, Rocco; Paone, Sara; Bosco, Francesca; Scarano, Federica; Scicchitano, Miriam; Ruga, Stefano; Zito, Maria Caterina; Colica, Carmen; Macri, Roberta; Palma, Ernesto] Nutramed Scarl, Complesso Nini Barbieri, I-88021 Catanzaro, Italy.
   [Ragusa, Salvatore] Magna Graecia Univ Catanzaro, Dept Hlth Sci, Catanzaro, Italy.
   [Muscoli, Carolina; Mollace, Vincenzo] San Raffaele IRCCS Pisana, Rome, Italy.
C3 Magna Graecia University of Catanzaro; Magna Graecia University of
   Catanzaro
RP Musolino, V; Mollace, V (corresponding author), Magna Graecia Univ Catanzaro, Dept Hlth Sci, Inst Res Food Safety & Hlth IRC FSH, Viale Europa, I-88100 Catanzaro, Italy.
EM xabaras3@hotmail.com; mollace@libero.it
RI Maiuolo, Jessica/AAU-2482-2020; Bosco, Francesca/HPF-0108-2023;
   Musolino, Vincenzo/AAD-2678-2019; nucera, saverio/AAC-6570-2022;
   Gliozzi, Micaela/D-4405-2015; Muscoli, Carolina/G-2773-2011; Colica,
   Carmela/AAY-4131-2020; carresi, cristina/AAC-6354-2022; Mollace,
   Rocco/ABH-5643-2020; SCARANO, FEDERICA/HNC-2414-2023; MACRI',
   Roberta/AAC-5967-2022; Ruga, Stefano/JUV-6384-2023
OI Ruga, Stefano/0009-0008-0401-4027; nucera, saverio/0000-0002-0000-4015;
   carresi, cristina/0000-0002-3509-5930; MACRI',
   Roberta/0000-0002-2345-6751; SCARANO, FEDERICA/0000-0002-9838-9469;
   Musolino, Vincenzo/0000-0002-4763-2211; Mollace,
   Rocco/0000-0002-7106-5595; Bosco, Francesca/0009-0004-4766-9710
FU MIUR [PON 03PE_00078_1, PON03PE_00078_2]
FX This work was supported by MIUR (PON 03PE_00078_1 and PON03PE_00078_2).
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NR 19
TC 42
Z9 43
U1 0
U2 3
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1476-511X
J9 LIPIDS HEALTH DIS
JI Lipids Health Dis.
PD MAY 17
PY 2019
VL 18
AR 115
DI 10.1186/s12944-019-1061-0
PG 8
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA HY8AA
UT WOS:000468358300001
PM 31101130
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Kajantie, E
   Eriksson, J
   Barker, DJP
   Forsén, T
   Osmond, C
   Wood, PJ
   Andersson, S
   Dunkel, L
   Phillips, DIW
AF Kajantie, E
   Eriksson, J
   Barker, DJP
   Forsén, T
   Osmond, C
   Wood, PJ
   Andersson, S
   Dunkel, L
   Phillips, DIW
TI Birthsize, gestational age and adrenal function in adult life:: studies
   of dexamethasone suppression and ACTH1-24 stimulation
SO EUROPEAN JOURNAL OF ENDOCRINOLOGY
LA English
DT Article
ID CORTICOTROPIN-RELEASING HORMONE; PLASMA-CORTISOL CONCENTRATIONS;
   INSULIN-RESISTANCE SYNDROME; CARDIOVASCULAR RISK-FACTORS; WEIGHT;
   STRESS; SECRETION; GENE; GLUCOCORTICOIDS; HYPOCORTISOLISM
AB Objective: Several studies show that low birthweight is associated with long-term alterations in the function of the hypothalamic-pituitary-adrenal axis (HPAA). We recently reported that the relationship between birthweight and fasting serum cortisol concentrations differed according to the gestational age of the babies, suggesting that both hypercortisolism and hypocortisolism could be a consequence of impaired fetal growth. We have now extended these findings by examining the relationship between birthweight, gestational age and tests of adrenal suppression and stimulation.
   Design: Prospective birth cohort study.
   Subjects and methods: We studied 165 women (mean age 71.3 years) born at term in Helsinki, Finland, between 1924 and 1933, whose body size and gestational age at birth were recorded. These women underwent an overnight 0.25 mg dexamethasone suppression test followed by a 1 mug ACTH(1-24) stimulation test.
   Results: In all women combined, low birthweight was associated with lower total (P = 0.03) and free (P = 0.02) cortisol concentrations following dexamethasone. However, these relationships were dependent on gestational age at birth, interactions between the effects of birth size and gestational age on dexamethasone responsiveness being statistically significant. To demonstrate these interactions, we divided the study population into two groups according to gestational age. In subjects born at 40 weeks of gestation or more, low birthweight was strongly associated with enhanced dexamethasone suppression (P = 0.003 for total and P = 0.0004 for free cortisol), while in subjects born before 40 weeks of gestation there was no association. There was, however, no correlation between birth size and the adrenal response to ACTH(1-24).
   Conclusions: These findings reinforce our suggestions that events during prenatal life may lead to both up-regulation and down-regulation of the HPAA.
C1 Univ Helsinki, Cent Hosp, Hosp Children & Adolescents, Helsinki 00029, Finland.
   Natl Publ Hlth Inst, SF-00300 Helsinki, Finland.
   Southampton Gen Hosp, MRC, Environm Epidemiol Unit, Southampton SO16 6YD, Hants, England.
C3 University of Helsinki; Helsinki University Central Hospital; Finland
   National Institute for Health & Welfare; University of Southampton
RP Kajantie, E (corresponding author), Univ Helsinki, Cent Hosp, Hosp Children & Adolescents, PL 280, Helsinki 00029, Finland.
RI Barker, David/A-5671-2013; Gibbs, J. Raphael/A-3984-2010
OI Eriksson, Johan/0000-0002-2516-2060; Osmond, Clive/0000-0002-9054-4655
FU NICHD NIH HHS [1R01 HD41107-01] Funding Source: Medline
CR Agarwal AK, 2000, HYPERTENSION, V36, P187, DOI 10.1161/01.HYP.36.2.187
   Bonte HA, 1999, CLIN CHEM LAB MED, V37, P127, DOI 10.1515/CCLM.1999.023
   CHALLIS JRG, 1989, BAILLIERE CLIN ENDOC, V3, P781, DOI 10.1016/S0950-351X(89)80053-9
   Eriksson JG, 2002, DIABETOLOGIA, V45, P342, DOI 10.1007/s00125-001-0757-6
   Fall CHD, 2002, J CLIN ENDOCR METAB, V87, P2001, DOI 10.1210/jc.87.5.2001
   Forsén T, 1999, BRIT MED J, V319, P1403, DOI 10.1136/bmj.319.7222.1403
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NR 26
TC 42
Z9 46
U1 0
U2 0
PU BIO SCIENTIFICA LTD
PI BRISTOL
PA EURO HOUSE, 22 APEX COURT WOODLANDS, BRADLEY STOKE, BRISTOL BS32 4JT,
   ENGLAND
SN 0804-4643
J9 EUR J ENDOCRINOL
JI Eur. J. Endocrinol.
PD DEC
PY 2003
VL 149
IS 6
BP 569
EP 575
DI 10.1530/eje.0.1490569
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 755PT
UT WOS:000187418500014
PM 14640999
OA Bronze
DA 2025-06-11
ER

PT J
AU Yousefzadeh, N
   Jeddi, S
   Zarkesh, M
   Norouzirad, R
   Kashfi, K
   Ghasemi, A
AF Yousefzadeh, Nasibeh
   Jeddi, Sajad
   Zarkesh, Maryam
   Norouzirad, Reza
   Kashfi, Khosrow
   Ghasemi, Asghar
TI Protective effects of long-term nitrate administration against
   ovariectomy-induced kidney dysfunction in rats
SO PHARMACOLOGICAL REPORTS
LA English
DT Article
DE Female rats; Nitrate; Kidney function; Nitric oxide deficiency;
   Oxidative stress; Ovariectomy
ID NITRIC-OXIDE SYNTHASE; OXIDATIVE STRESS; DIETARY NITRATE;
   BLOOD-PRESSURE; INORGANIC NITRATE; RENAL-DISEASE; POSTMENOPAUSAL WOMEN;
   REPLACEMENT THERAPY; METABOLIC SYNDROME; ESTROGEN-RECEPTOR
AB Background Menopause is associated with higher risks of chronic kidney disease. We determined the effect of nitrate on ovariectomy-induced kidney dysfunction Methods Control, ovariectomized (OVX), control + nitrate, and OVX + nitrate female Wistar rats (n = 10/group); sodium nitrate (100 mg/L) administered in drinking water for 9 months. Glomerular filtration rate (GFR) and albumin excretion rate ( AER) were calculated from serum and urine parameters. At month 9, serum and kidney levels of nitric oxide (NO) metabolites ( NOx), oxidative stress indices, and mRNA expression of endothelial NO synthase (eNOS) were measured; with histological analyses of the kidney. Results Compared to controls, OVX rats had lower GFR (31%, p = 0.0079), higher glomerular tuft volume (30%, p = 0.0402), and Bowman's capsule space (39%, p = 0.0224). OVX rats had lower serum NOx (33%, p = 0.0061) and kidney eNOS mRNA expression (34%, p = 0.0368). Nitrate administration to: (i) control rats increased serum NOx (59%, p < 0.0001), with no effect on other parameters; (ii) OVX rats increased serum (85%, p < 0.0001) and kidney ( 106%, p = 0.0008) NOx values, and restored kidney eNOS expression to normal value. Nitrate administration to OVX rats increased GFR (36%, p = 0.0361) and restored glomerular tuft volume and Bowman's capsule space to normal values. In OVX rats, it also increased serum catalase (CAT) activity, serum and kidney total antioxidant capacity (TAC), and decreased serum malondialdehyde (MDA). Conclusions Low-dose long-term nitrate administration protects against ovariectomy-induced kidney dysfunction in rats. This effect is associated with reducing ovariectomy-induced oxidative stress and restoring eNOS-derived NO deficiency in systemic circulation and the kidney.
C1 [Yousefzadeh, Nasibeh; Jeddi, Sajad; Ghasemi, Asghar] Shahid Beheshti Univ Med Sci, Res Inst Endocrine Sci, Endocrine Physiol Res Ctr, Tehran, Iran.
   [Zarkesh, Maryam] Shahid Beheshti Univ Med Sci, Res Inst Endocrine Sci, Cellular & Mol Endocrine Res Ctr, Tehran, Iran.
   [Norouzirad, Reza] Dezful Univ Med Sci, Sch Med, Dept Biochem, Dezful, Iran.
   [Kashfi, Khosrow] CUNY, Sophie Davis Sch Biomed Educ, Sch Med, Dept Mol Cellular & Biomed Sci, New York, NY USA.
C3 Shahid Beheshti University Medical Sciences; Shahid Beheshti University
   Medical Sciences; City University of New York (CUNY) System; Sophie
   Davis School of Biomedical Education
RP Ghasemi, A (corresponding author), Shahid Beheshti Univ Med Sci, Res Inst Endocrine Sci, Endocrine Physiol Res Ctr, Tehran, Iran.
EM Ghasemi@endocrine.ac.ir
RI Zarkesh, Maryam/ABC-1782-2021; Jeddi, Sajad/U-8493-2019; Ghasemi,
   Asghar/O-4145-2017; Norouzirad, Reza/L-7475-2015; Kashfi,
   Khosrow/A-4351-2008
OI Ghasemi, Asghar/0000-0001-6867-2151; Norouzirad,
   Reza/0000-0002-5046-057X; Kashfi, Khosrow/0000-0002-4060-7283
FU Shahid Beheshti University of Medical Sciences [286715]
FX This study was supported by a grant (Grant No. 28671-5) from Shahid
   Beheshti University of Medical Sciences.
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NR 90
TC 3
Z9 3
U1 0
U2 3
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1734-1140
EI 2299-5684
J9 PHARMACOL REP
JI Pharmacol. Rep.
PD AUG
PY 2023
VL 75
IS 4
BP 979
EP 994
DI 10.1007/s43440-023-00499-9
EA JUN 2023
PG 16
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA M9PH9
UT WOS:001000177500001
PM 37258800
DA 2025-06-11
ER

PT J
AU Luong, A
   Tawfik, AN
   Islamoglu, H
   Gobriel, HS
   Ali, N
   Ansari, P
   Shah, R
   Hung, T
   Patel, T
   Henson, B
   Thankam, F
   Lewis, J
   Mintline, M
   Boehm, T
   Tumur, Z
   Seleem, D
AF Luong, Anthony
   Tawfik, Andy Nassif
   Islamoglu, Hicret
   Gobriel, Hanaa Selim
   Ali, Nada
   Ansari, Pouya
   Shah, Ruchita
   Hung, Tiffany
   Patel, Tanusha
   Henson, Bradley
   Thankam, Finosh
   Lewis, Jill
   Mintline, Mark
   Boehm, Tobias
   Tumur, Zohra
   Seleem, Dalia
TI Periodontitis and diabetes mellitus co-morbidity: A molecular dialogue
SO JOURNAL OF ORAL BIOSCIENCES
LA English
DT Review
DE Diabetes mellitus; Periodontitis; Microbiome; Dysbiosis; Glycation end
   products, advanced
ID HUMAN GINGIVAL FIBROBLASTS; 1-PERCENT ALENDRONATE GEL; PLATELET-RICH
   FIBRIN; PORPHYROMONAS-GINGIVALIS; METABOLIC SYNDROME; OXIDATIVE STRESS;
   NITRIC-OXIDE; ORAL MANIFESTATIONS; BONE METABOLISM; GENE-EXPRESSION
AB Background: Type 2 diabetes mellitus (T2DM) and periodontitis are two biologically linked diseases that often coexist in complex interaction. While periodontitis may lead to insulin receptor desensitization, diabetes may increase the expression of inflammatory cytokines, such as Tumor Necrosis Factor-alpha (TNF-alpha) and Interleukin 6 (IL-6), in the gingival crevicular fluid and activate osteoclasts via Receptor activator of nuclear factor kappa-Beta ligand (RANK-L) production, leading to bone resorption. However, the association between the two diseases processes, where one may exacerbate the progression of the other, is unclear. In addition, both diseases have similar mechanistic themes, such as chronic inflammation and oxidative stress. This review aimed to investigate the pathophysiological and molecular mechanisms underlying T2DM and periodontitis.
   Highlight: Uncontrolled diabetes is often associated with severe periodontitis, measured by clinical attachment loss. Alteration in the oral microbiome composition, which may activate the host inflammatory response and lead to irreversible oxidative stress, is a common finding in both diseases. An understanding of the molecular crosstalk between the two disease processes is crucial for developing therapeutic targets that inhibit bone resorption and halt the progression of periodontitis in patients with diabetes.
   Conclusion: The Oral microbiome composition in T2DM and periodontitis shifts toward dysbiosis, favoring bacterial pathogens, such as Fusobacteria and Porphyromonas species. Both conditions are marked by pro-inflammatory immune activity via the activation of Interleukin 17 (IL-17), Interleukin 1 (IL-1), TNF-alpha, and Nuclear Factor Kappa Beta (NF-kappa B). Common molecular crosstalk signaling appears to involve advanced glycation end products (AGEs) and oxidative stress. Thus, future drug targets are multifactorial, ranging from modulatory of host inflammatory response to preventing the accumulation of AGEs and oxidative free radicals. (C) 2021 Japanese Association for Oral Biology. Published by Elsevier B.V. All rights reserved.
C1 [Luong, Anthony; Tawfik, Andy Nassif; Islamoglu, Hicret; Gobriel, Hanaa Selim; Ali, Nada; Ansari, Pouya; Shah, Ruchita; Hung, Tiffany; Patel, Tanusha; Henson, Bradley; Lewis, Jill; Mintline, Mark; Boehm, Tobias; Tumur, Zohra; Seleem, Dalia] Western Univ Hlth Sci, Coll Dent Med, 309 E Second St, Pomona, CA 91766 USA.
   [Thankam, Finosh] Western Univ Hlth Sci, Coll Osteopath Med, Pomona, CA 91766 USA.
C3 Western University of Health Sciences; Western University of Health
   Sciences
RP Seleem, D (corresponding author), Western Univ Hlth Sci, Coll Dent Med, 309 E Second St, Pomona, CA 91766 USA.
EM Dalia.seleem@westernu.edu
OI Hung, Tiffany/0000-0002-6562-8582; Luong, Anthony/0000-0002-1261-8823
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NR 132
TC 38
Z9 41
U1 1
U2 14
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1349-0079
EI 1880-3865
J9 J ORAL BIOSCI
JI J. Oral Biosci.
PD DEC
PY 2021
VL 63
IS 4
BP 360
EP 369
DI 10.1016/j.job.2021.10.006
EA DEC 2021
PG 10
WC Dentistry, Oral Surgery & Medicine
WE Emerging Sources Citation Index (ESCI)
SC Dentistry, Oral Surgery & Medicine
GA XL4AK
UT WOS:000728087600006
PM 34728373
DA 2025-06-11
ER

PT J
AU Kose, O
   Arabaci, T
   Kara, A
   Yemenoglu, H
   Kermen, E
   Kizildag, A
   Gedikli, S
   Ozkanlar, S
AF Kose, Oguz
   Arabaci, Taner
   Kara, Adem
   Yemenoglu, Hatice
   Kermen, Eda
   Kizildag, Alper
   Gedikli, Semin
   Ozkanlar, Seckin
TI Effects of Melatonin on Oxidative Stress Index and Alveolar Bone Loss in
   Diabetic Rats With Periodontitis
SO JOURNAL OF PERIODONTOLOGY
LA English
DT Article
DE Anti-inflammatory agents; antioxidants; diabetes mellitus; melatonin;
   oxidative stress; periodontitis
ID GINGIVAL CREVICULAR FLUID; LIPID-PEROXIDATION LEVELS; ALPHA-LIPOIC ACID;
   REACTIVE OXYGEN; ANTIOXIDANT ENZYMES; METABOLIC SYNDROME; POTENTIAL
   ROLE; SERUM; DISEASE; SALIVA
AB Background: The aim of this study is to evaluate the effects of systemic melatonin treatment on serum oxidative stress index (OSI) and alveolar bone loss (ABL) in rats with diabetes mellitus (DM) and periodontitis.
   Methods: Seventy Sprague Dawley rats were divided into control, experimentally induced periodontitis (EP), DM, EP-DM, EP and melatonin treatment (EP-MEL), DM and melatonin treatment (DMMEL), and EP-DM-MEL groups. DM was induced by alloxan, after which periodontitis was induced by ligature for 4 weeks. After removal of the ligature, the rats in the melatonin groups (EP-MEL, DM-MEL, and EP-DM-MEL) were treated with a single dose of melatonin (10 mg/body weight) every day for 14 consecutive days. At the end of the study, all of the rats were euthanized, and intracardiac blood samples and mandible tissues were obtained for biochemical and histologic analyses. Serum levels of total oxidant status/total antioxidant status and OSI were measured. In addition, neutrophil and osteoclast densities and myeloperoxidase activities were determined in gingival tissue homogenates, and ABL was evaluated with histometric measurements.
   Results: Melatonin treatment significantly reduced fasting plasma glucose levels in the rats with DM. In addition, reduced OSI and ABL levels were detected in the EP-MEL and DM-MEL groups; the reductions in the EP-DM-MEL group were found to be more prominent. Melatonin also significantly decreased the increased myeloperoxidase activities and osteoclast and neutrophil densities in the EP, DM, and EP-DM groups.
   Conclusion: It is revealed in this experimental study that melatonin significantly inhibited hyperglycemia-induced oxidative stress and ABL through antiDM and antioxidant effects in rats with DM and periodontitis.
C1 [Kose, Oguz; Yemenoglu, Hatice] Recep Tayyip Erdogan Univ, Fac Dent, Dept Periodontol, TR-53100 Rize, Turkey.
   [Arabaci, Taner; Kermen, Eda] Ataturk Univ, Fac Dent, Dept Periodontol, Erzurum, Turkey.
   [Kara, Adem; Gedikli, Semin] Ataturk Univ, Fac Vet Med, Dept Histol & Embryol, Erzurum, Turkey.
   [Kizildag, Alper] Pamukkale Univ, Fac Dent, Dept Periodontol, Denizli, Turkey.
   [Ozkanlar, Seckin] Ataturk Univ, Fac Vet Med, Dept Biochem, Erzurum, Turkey.
C3 Recep Tayyip Erdogan University; Ataturk University; Ataturk University;
   Pamukkale University; Ataturk University
RP Kose, O (corresponding author), Recep Tayyip Erdogan Univ, Fac Dent, Dept Periodontol, TR-53100 Rize, Turkey.
EM dtoguzkose61@hotmail.com
RI Kara, Adem/J-4911-2013; KIZILDAĞ, Alper/HJP-0870-2023; kose,
   oguz/KHC-7197-2024; Gedikli, Semin/AHB-0544-2022; Yemenoglu,
   Hatice/KHD-2761-2024
OI OZKANLAR, Seckin/0000-0001-7717-797X; Gedikli, Semin/0000-0001-8238-7226
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NR 50
TC 53
Z9 56
U1 2
U2 33
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-3492
EI 1943-3670
J9 J PERIODONTOL
JI J. Periodont.
PD MAY
PY 2016
VL 87
IS 5
BP E82
EP E90
DI 10.1902/jop.2016.150541
PG 9
WC Dentistry, Oral Surgery & Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dentistry, Oral Surgery & Medicine
GA DL7TQ
UT WOS:000375843400004
PM 26832833
DA 2025-06-11
ER

PT J
AU Pirgon, Ö
   Bilgin, H
   Çekmez, F
   Kurku, H
   Dündar, BN
AF Pirgon, Ozgur
   Bilgin, Huseyin
   Cekmez, Ferhat
   Kurku, Huseyin
   Dundar, Bumin Nuri
TI Association Between Insulin Resistance and Oxidative Stress Parameters
   in Obese Adolescents with Non-Alcoholic Fatty Liver Disease
SO JOURNAL OF CLINICAL RESEARCH IN PEDIATRIC ENDOCRINOLOGY
LA English
DT Article
DE Non-alcoholic fatty liver disease; total antioxidant status; oxidative
   stress; obesity; insulin resistance; childhood
ID SERUM ALANINE AMINOTRANSFERASE; TOTAL ANTIOXIDANT CAPACITY;
   LIPID-PEROXIDATION; METABOLIC SYNDROME; CHILDREN; STEATOHEPATITIS;
   PREVALENCE; IMPACT; WOMEN
AB Objective: Non-alcoholic fatty liver disease (NAFLD) has become one of the most common chronic liver diseases in children. The aim of this study was to investigate the associations of oxidative stress with insulin resistance and metabolic risk factors in obese adolescents with NAFLD.
   Methods: Forty-six obese adolescents (23 girls and 23 boys, mean age: 12.8 +/- 2.2 years) and 29 control subjects (15 girls and 14 boys, mean age: 12.7 +/- 2.7 years) were enrolled in the study. The obese subjects were divided into two groups (NAFLD group and non-NAFLD group) based on the elevated alanine aminotransferase levels (>30 IU/L) and the presence or absence of liver steatosis detected by ultrasonography. Insulin resistance was evaluated by homeostasis model assessment (HOMA-IR) from fasting samples. Plasma total antioxidant status (TAS) and total oxidant status (TOS) level measurements (REL Assay Diagnostics) were done in all participants. The ratio of TOS to TAS was regarded as an oxidative stress index (OSI), an indicator of the degree of OS.
   Results: Fasting insulin levels and HOMA-IR values in the NAFLD group were significantly higher than in the non-NAFLD and control groups. TAS measurements were decreased in both obese groups (NAFLD and non-NAFLD) in comparison with the control group. TOS and OSI measurements were higher in the NAFLD group than in the non-NAFLD and control groups. OSI was positively correlated with fasting insulin (r=0.67, p=0.01) and HOMA-IR (r=0.71, p=0.02) in the NAFLD obese group.
   Conclusions: In this cross-sectional study, elevated OS markers in obese adolescents with NAFLD were associated with insulin resistance. This data suggest that an antioxidant therapy might have a potential for treating NAFLD associated with insulin resistance.
C1 [Pirgon, Ozgur] Suleyman Demirel Univ, Fac Med, Dept Pediat Endocrinol Endocrinol & Diabet, TR-32200 Isparta, Turkey.
   [Bilgin, Huseyin] Konya Res Hosp, Dept Pediat Endocrinol & Diabet, Konya, Turkey.
   [Cekmez, Ferhat] GATA Med Fac, Dept Pediat, Ankara, Turkey.
   [Kurku, Huseyin] Konya Res Hosp, Dept Biochem, Konya, Turkey.
   [Dundar, Bumin Nuri] Katip Celebi Univ, Fac Med, Dept Pediat Endocrinol, Izmir, Turkey.
C3 Suleyman Demirel University; Konya Egitim Training & Research Hospital;
   Gulhane Military Medical Academy; Konya Egitim Training & Research
   Hospital; Izmir Katip Celebi University
RP Pirgon, Ö (corresponding author), Suleyman Demirel Univ, Fac Med, Dept Pediat Endocrinol Endocrinol & Diabet, TR-32200 Isparta, Turkey.
EM ozgurpirgon@gmail.com
RI Dündar, Bumin/JVE-1747-2024; Bilgin, Huseyin/JMQ-9930-2023; DOKMETAS,
   Hatice Sebile/MVX-8725-2025; Kurku, Huseyin/Q-4616-2018
OI Kurku, Huseyin/0000-0002-1083-4151; Dundar, Bumin N/0000-0002-7506-061X
CR Chan DFY, 2004, INT J OBESITY, V28, P1257, DOI 10.1038/sj.ijo.0802734
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NR 41
TC 62
Z9 67
U1 0
U2 23
PU GALENOS YAYINCILIK
PI FINDIKZADE
PA ERKAN MOR, MOLLA GURANI CAD 21-1, FINDIKZADE, ISTANBUL 34093, TURKEY
SN 1308-5727
EI 1308-5735
J9 J CLIN RES PEDIATR E
JI J. Clin Res. Pediatr. Endocrinol.
PY 2013
VL 5
IS 1
BP 33
EP 39
DI 10.4274/Jcrpe.825
PG 7
WC Endocrinology & Metabolism; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Pediatrics
GA AM1ZZ
UT WOS:000339649100006
PM 23367495
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Rosing, K
   Fobker, M
   Kannenberg, F
   Gunia, S
   Dell'Aquila, AM
   Kwiecien, R
   Stypmann, J
   Nofer, JR
AF Rosing, Katharina
   Fobker, Manfred
   Kannenberg, Frank
   Gunia, Stefan
   Dell'Aquila, Angelo Maria
   Kwiecien, Robert
   Stypmann, Joerg
   Nofer, Jerzy-Roch
TI Everolimus therapy is associated with reduced lipoprotein-associated
   phospholipase A2 (Lp-Pla2) activity and oxidative
   stress in heart transplant recipients
SO ATHEROSCLEROSIS
LA English
DT Article
DE Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)); Everolimus
   oxidative stress; Cardiovascular risk; Heart transplantation;
   Atherosclerosis
ID CARDIAC ALLOGRAFT VASCULOPATHY; CORONARY-ARTERY-DISEASE;
   LOW-DENSITY-LIPOPROTEIN; C-REACTIVE PROTEIN; ATHEROSCLEROTIC PLAQUE;
   INTRAVASCULAR ULTRASOUND; SYSTEMIC INFLAMMATION; METABOLIC SYNDROME;
   MULTICENTER TRIAL; DEFICIENT MICE
AB Background: Several studies demonstrated decreased severity and incidence of cardiac allograft vasculopathy (CAV) in heart transplant recipients receiving immunosuppressive therapy with everolimus. However, data regarding the influence of everolimus on risk factors predisposing to CAV are hitherto limited. We here systematically evaluated cardiovascular risk factors in heart transplanted patients, who underwent conversion to everolimus or were maintained on conventional therapy with calcineurin inhibitors (CNI).
   Methods: 50 Patients receiving everolimus and 91 patients receiving CNI in addition to mycophenolate mofetil and low-dosed steroids were included in the study. CAV risk factors were determined in plasma or urine using standard enzymatic or immunochemical methods.
   Results: No significant differences were observed between both groups with regard to lipid (total, LDL- and HDL-cholesterol), metabolic (glucose, insulin), inflammatory (C-reactive protein, IL-6, myeloperoxidase) and cardiac (troponin I, NT-proBNP) risk factors. However, significantly lower activity of lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) and a negative correlation between the Lp-PLA(2) activity and the everolimus concentration were observed in plasmas from everolimus-treated patients. Conversion to everolimus significantly lowered Lp-PLA(2) activity in heart transplant recipients. Studies in vitro revealed reduced Lp-PLA(2) expression in hepatocytes and macrophages pre-exposed to everolimus. In addition, reduced plasma markers of oxidative stress including oxidized LDL, 8-iso-prostaglandin F-2 alpha and protein carbonyls were noted in heart transplant recipients receiving everolimus therapy.
   Conclusion: Our results suggest that everolimus specifically lowers plasma activity and cellular production of Lp-PLA(2) and thereby dampens oxidative stress. These effects may additionally contribute to the reduced CAV incidence observed in heart transplant recipients receiving everolimus therapy. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
C1 [Rosing, Katharina; Fobker, Manfred; Kannenberg, Frank; Nofer, Jerzy-Roch] Univ Hosp Munster, Ctr Lab Med, Munster, Germany.
   [Gunia, Stefan; Stypmann, Joerg] Univ Hosp Munster, Dept Cardiovasc Med, Munster, Germany.
   [Dell'Aquila, Angelo Maria] Univ Hosp Munster, Dept Cardiothorac Surg, Munster, Germany.
   [Kwiecien, Robert] Univ Munster, Inst Biostat & Clin Res, D-48149 Munster, Germany.
   [Nofer, Jerzy-Roch] Univ Modena & Reggio Emilia, Dept Biomed Metab & Neural Sci, Modena, Italy.
C3 University of Munster; University of Munster; University of Munster;
   University of Munster; Universita di Modena e Reggio Emilia
RP Nofer, JR (corresponding author), Univ Klinikum Munster, Ctr Lab Med, Albert Schweizer Campus 1,Gebaude A1, D-48149 Munster, Germany.
EM nofer@uni-muenster.de
RI Dell'Aquila, Angelo/AAJ-6462-2021
OI Dell'Aqula, Angelo M/0000-0002-5748-4275
FU Novartis Pharma GmbH, Hamburg, Germany; Center for Laboratory Medicine
FX This work was supported by Novartis Pharma GmbH, Hamburg, Germany (to
   J.S. and J.-R.N.) and intramural resources of the Center for Laboratory
   Medicine (to J.-R.N.).
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NR 50
TC 14
Z9 16
U1 0
U2 11
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0021-9150
J9 ATHEROSCLEROSIS
JI Atherosclerosis
PD SEP
PY 2013
VL 230
IS 1
BP 164
EP 170
DI 10.1016/j.atherosclerosis.2013.07.007
PG 7
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 206XS
UT WOS:000323560400026
PM 23958269
DA 2025-06-11
ER

PT J
AU Gaemers, IC
   Stallen, JM
   Kunne, C
   Wallner, C
   van Werven, J
   Nederveen, A
   Lamers, WH
AF Gaemers, Ingrid C.
   Stallen, Jan M.
   Kunne, Cindy
   Wallner, Christian
   van Werven, Jochem
   Nederveen, Aart
   Lamers, Wouter H.
TI Lipotoxicity and steatohepatitis in an overfed mouse model for
   non-alcoholic fatty liver disease
SO BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
LA English
DT Article
DE Non-alcoholic fatty liver disease; Steatohepatitis; Liver;
   Overnutrition; High-fat diet; Endoplasmatic reticulum stress; Adipose
   tissue
ID ENDOPLASMIC-RETICULUM STRESS; HEPATIC CYTOCHROME-P450 2E1; UNFOLDED
   PROTEIN RESPONSE; SERUM FGF21 LEVELS; OXIDATIVE STRESS; INSULIN
   SENSITIVITY; METABOLIC SYNDROME; DIABETES-MELLITUS; HEME OXYGENASE-1;
   ADIPOSE-TISSUE
AB The major risk factors for non-alcoholic fatty liver disease (NAFLD) are obesity, insulin resistance and dyslipidemia. The cause for progression from the steatosis stage to the inflammatory condition (non-alcoholic steatohepatitis (NASH)) remains elusive at present. Aim of this study was to test whether the different stages of NAFLD as well as the associated metabolic abnormalities can be recreated in time in an overfed mouse model and study the mechanisms underlying the transition from steatosis to NASH.
   Male C57BI/6J mice were subjected to continuous intragastric overfeeding with a high-fat liquid diet (HFLD) for different time periods. Mice fed a solid high-fat diet (HFD) ad libitum served as controls. Liver histology and metabolic characteristics of liver, white adipose tisue (WAT) and plasma were studied.
   Both HFD-fed and HFLD-overfed mice initially developed liver steatosis, but only the latter progressed in time to NASH. NASH coincided with obesity, hyperinsulinemia, loss of liver glycogen and hepatic endoplasmatic reticulum stress. Peroxisome proliferator-activated receptor gamma (Ppary), fibroblast growth factor 21 (Fgf21), fatty acid binding protein (Fabp) and fatty acid translocase (CD36) were induced exclusively in the livers of the HFLD-overfed mice. Inflammation, reduced adiponectin expression and altered expression of genes that influence adipogenic capacity were only observed in WAT of HFLD-overfed mice.
   In conclusion: this dietary mouse model displays the different stages and the metabolic settings often found in human NAFLD. Lipotoxicity due to compromised adipose tissue function is likely associated with the progression to NASH, but whether this is cause or consequence remains to be established. (C) 2011 Elsevier B.V. All rights reserved.
C1 [Gaemers, Ingrid C.; Stallen, Jan M.; Kunne, Cindy; Lamers, Wouter H.] Univ Amsterdam, Acad Med Ctr, Tytgat Inst Liver & Intestinal Res, NL-1105 BK Amsterdam, Netherlands.
   [Wallner, Christian; van Werven, Jochem; Nederveen, Aart] Univ Amsterdam, Acad Med Ctr, NL-1105 AZ Amsterdam, Netherlands.
C3 University of Amsterdam; Academic Medical Center Amsterdam; University
   of Amsterdam; Academic Medical Center Amsterdam
RP Gaemers, IC (corresponding author), Univ Amsterdam, Acad Med Ctr, Tytgat Inst Liver & Intestinal Res, Meibergdreef 71, NL-1105 BK Amsterdam, Netherlands.
EM i.c.gaemers@amc.uva.nl
RI Lamers, Wouter/D-2965-2012
FU Norgine Ltd. (Uxbridge, Middlesex, UK)
FX Authors thank Jan M. Ruijter (statistical and MRI image analysis), Bouke
   A. de Boer (MRI image analysis), Nanda van Eeken (surgery) and all
   personnel of the AMC animal facility (ARIA). This work was supported in
   part by Norgine Ltd. (Uxbridge, Middlesex, UK).
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NR 53
TC 74
Z9 91
U1 0
U2 21
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0925-4439
EI 0006-3002
J9 BBA-MOL BASIS DIS
JI Biochim. Biophys. Acta-Mol. Basis Dis.
PD APR
PY 2011
VL 1812
IS 4
BP 447
EP 458
DI 10.1016/j.bbadis.2011.01.003
PG 12
WC Biochemistry & Molecular Biology; Biophysics; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Cell Biology
GA 733YX
UT WOS:000288301500004
PM 21216282
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Fang, CX
   Dong, F
   Ren, BH
   Epstein, PN
   Ren, J
AF Fang, CX
   Dong, F
   Ren, BH
   Epstein, PN
   Ren, J
TI Metallothionein alleviates cardiac contractile dysfunction induced by
   insulin resistance:: role of Akt phosphorylation, PTB1B, PPARγ and
   c-Jun
SO DIABETOLOGIA
LA English
DT Article
DE antioxidant; insulin resistance; intracellular Ca2+ transients; myocyte;
   shortening
ID GROWTH-FACTOR-I; ACTIVATED RECEPTOR-GAMMA; OBESE ZUCKER RATS; DIABETIC
   CARDIOMYOPATHY; VENTRICULAR MYOCYTES; IGF-I; MUSCLE; OVEREXPRESSION;
   HEART; MICE
AB Aims/hypothesis: Insulin resistance is concomitant with metabolic syndrome, oxidative stress and cardiac contractile dysfunction. However, the causal relationship between oxidative stress and cardiac dysfunction is unknown. This study was designed to determine the impact of overexpression of the cardiac antioxidant metallothionein on cardiac dysfunction induced by insulin resistance in mice. Methods: Whole-body insulin resistance was generated in wild-type FVB and metallothionein transgenic mice by feeding them with sucrose for 12 weeks. Contractile and intracellular Ca-90(90)90(2+ properties were evaluated in ventricular myocytes using an IonOptix system. The contractile indices analysed included: peak shortening (PS), time to 90% PS (TPS)), time to 90% relengthening (TR(), half-width duration, maximal velocity of shortening (+dL/dt) and relengthening (-dL/dt), fura-fluorescence intensity change (DFFI) and decay rate (t). Results: The sucrose-fed mice displayed glucose intolerance, enhanced oxidative stress, hyperinsulinaemia, hypertriglyceridaemia and normal body weight. Compared with myocytes in starch-fed mice, those from sucrose-fed mice exhibited depressed PS, +dL/dt, -dL/dt, prolonged TR) (and decay rate, and reduced DFFI associated with normal TPS)(90) and half-width duration. Western blot analysis revealed enhanced basal, but blunted insulin (15 mU/g)-stimulated Akt phosphorylation. It also showed elevated expression of insulin receptor b, insulin receptor tyrosine phosphorylation, peroxisome proliferator-activated receptor g, protein tyrosine phosphatase 1B and phosphorylation of the transcription factor c-Jun, associated with a reduced fold increase of insulin-stimulated insulin receptor tyrosine phosphorylation in sucrose-fed mice. All western blot findings may be attenuated or ablated by metallothionein. Conclusions/interpretation: These data indicate that oxidative stress may play an important role in cardiac contractile dysfunction associated with glucose intolerance and possibly related to alteration in insulin signalling at the receptor and post-receptor levels.
C1 Univ Wyoming, Div Pharmaceut Sci, Laramie, WY 82071 USA.
   Univ Wyoming, Ctr Cardiovasc Res & Alternat Med, Laramie, WY 82071 USA.
   Univ Louisville, Dept Pediat, Louisville, KY 40292 USA.
C3 University of Wyoming; University of Wyoming; University of Louisville
RP Univ Wyoming, Div Pharmaceut Sci, Laramie, WY 82071 USA.
EM jren@uwyo.edu
RI fang, xin/HMP-4060-2023; Ren, Jun/ACG-5366-2022
OI Epstein, Paul/0000-0002-7006-8954; Ren, Jun/0000-0002-0275-0783
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NR 50
TC 55
Z9 59
U1 0
U2 4
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0012-186X
EI 1432-0428
J9 DIABETOLOGIA
JI Diabetologia
PD NOV
PY 2005
VL 48
IS 11
BP 2412
EP 2421
DI 10.1007/s00125-005-1940-y
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 983QW
UT WOS:000233248200030
PM 16172869
OA Bronze
DA 2025-06-11
ER

PT J
AU Morrison, EY
   Ragoobirsingh, D
   Peter, SA
AF Morrison, E. Y.
   Ragoobirsingh, D.
   Peter, S. A.
TI The Unitarian Hypothesis for the aetiology of diabetes mellitus
SO MEDICAL HYPOTHESES
LA English
DT Article
ID ANNATTO BIXA-ORELLANA; OXIDATIVE STRESS; CARDIOVASCULAR MORBIDITY;
   GLUCOSE; HYPERTENSION; MORTALITY; INTERVENTION; GENERATION; PREVENTION;
   TOXICITY
AB Over the years, several clinical syndromes have been described in diabetes mellitus. Although world opinion has settled somewhat on the main two types, the debate continues as to how the 'formes frustes' syndromes fit in and what if any implications there are for the accepted aetiology of the disease.
   Type 1, insulin dependent diabetes mellitus, results from pancreatic inadequacy as a result of a variety of insults such as autoimmune attack, toxic damage, etc. Insulin administration is at the core of the therapeutic approach.
   Type 2, non insulin dependent diabetes mellitus, results from reduced responsiveness of the target tissues to insulin and as such, an insulin resistance syndrome is described. Lifestyle adjustment and oral hypoglycaemic agents are the mainstay of therapy.
   Over the years, however, insulin insufficiency will develop in most cases and insulin therapy required in order to achieve normoglycaemia.
   The aetiotogy of these main two types has been maintained to be distinct from each other and as such types 1 and 2 are described as two separate developmental conditions.
   Furthermore, the variant patterns, such as malnutrition related, drug induced, intermittent or phasic insulin requiring, gestational, temporary, stress related, etc., all present a challenge as to how they fit in aetiologically.
   The Unitarian Hypothesis, by presenting this overall cascade of biochemical and physiological interactions, brings a logic which embraces the points of entry of a variety of insults, all of which can lead to the clinical picture of hyperglycaemia and its attendant adverse outcomes.
   The causative agents functioning internally within the cascade are imputed to be free radicals, oxidizing molecular species and antibodies and the corollary to this overview concept would be that a situation that minimizes the genesis and accumulation of these three agents would minimize the development of diabetes mettitus.
   Currently the debate is rife about the use of free radical scavengers and antioxidants in the treatment and prevention of diabetes mellitus. The verdict is stilt out on this approach. Our research on rootcrops such as yams and cassava, staple foods in tropical countries, indicates the presence of cyanoglycosides such as linamarin, which on digestion yields cyanide radicals. These radicals are pancreatotoxic especially in the undernourished state. Dog models however, have shown that free radical scavengers such as riboflavin, Vitamin 132, is protective against this toxic damage.
C1 Univ W Indies, Kingston 7, Jamaica.
   Univ W Indies, Nassau, Bahamas.
C3 University West Indies Mona Jamaica
RP Morrison, EY (corresponding author), Univ W Indies, Mona Campus, Kingston 7, Jamaica.
EM errol.morrison@bluecross.com.jm
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NR 31
TC 14
Z9 14
U1 0
U2 11
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0306-9877
EI 1532-2777
J9 MED HYPOTHESES
JI Med. Hypotheses
PY 2006
VL 67
IS 5
BP 1115
EP 1120
DI 10.1016/j.mehy.2006.04.061
PG 6
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 087LJ
UT WOS:000240743600019
PM 16806731
DA 2025-06-11
ER

PT J
AU Fukushima, J
   Kamada, Y
   Matsumoto, H
   Yoshida, Y
   Ezaki, H
   Takemura, T
   Saji, Y
   Igura, T
   Tsutsui, S
   Kihara, S
   Funahashi, T
   Shimomura, I
   Tamura, S
   Kiso, S
   Hayashi, N
AF Fukushima, Juichi
   Kamada, Yoshihiro
   Matsumoto, Hitoshi
   Yoshida, Yuichi
   Ezaki, Hisao
   Takemura, Takayo
   Saji, Yukiko
   Igura, Takumi
   Tsutsui, Shusaku
   Kihara, Shinji
   Funahashi, Tohru
   Shimomura, Iichiro
   Tamura, Shinji
   Kiso, Shinichi
   Hayashi, Norio
TI Adiponectin prevents progression of steatohepatitis in mice by
   regulating oxidative stress and Kupffer cell phenotype polarization
SO HEPATOLOGY RESEARCH
LA English
DT Article
DE adiponectin; catalase; Kupffer cell phenotype polarization; nonalcoholic
   steatohepatitis (NASH); oxidative stress; PPAR alpha
ID NECROSIS-FACTOR-ALPHA; NONALCOHOLIC STEATOHEPATITIS; INSULIN-RESISTANCE;
   HEPATITIS-C; METABOLIC SYNDROME; ADIPOSE-TISSUE; LIVER FIBROSIS;
   VISCERAL FAT; RISK-FACTOR; PPAR-GAMMA
AB Aim:
   We reported previously that hypoadiponectinemia enhances hepatic oxidative stress and accelerates progression of nonalcoholic steatohepatitis (NASH) in mice. However, the precise mechanism and preventive effects of adiponectin on NASH remain unclear. The aim of this study was to examine the effects of adiponectin on steatohepatitis using adiponectin-knockout (KO) mice and adenovirus-mediated adiponectin expression system.
   Methods:
   We used male KO mice and C57BL6/J (WT) mice fed methionine choline-deficient (MCD)-diet as a steatohepatitis model. Liver histology, hepatic oxidative stress markers, and hepatic gene expression levels were investigated. In addition, Hepa 1-6 cells, a mouse liver cell line, were cultured with or without recombinant adiponectin, and gene expressions were investigated by real-time RT-PCR.
   Results:
   After 2-week feeding of MCD diet, hepatic steatosis was enhanced and plasma alanine aminotransferase elevated in KO mice than in WT mice. In KO mice liver, thiobarbituric acid reactive substances increased, glutathione levels decreased, and mRNA expression levels of antioxidant enzymes (catalase, superoxide dismutase-1) downregulated. Adenovirus-mediated adiponectin expression prevented these changes in KO mice. Moreover, Kupffer cell infiltration was enhanced and mRNA levels of anti-inflammatory M2 macrophage markers (interleukin-10, arginase-1) were decreased in KO mice liver. In the in vitro study, adiponectin significantly increased catalase gene expression in Hepa 1-6 cells.
   Conclusions:
   Lack of adiponectin enhanced, and adiponectin administration prevented steatohepatitis progression in mice. These changes were due to the anti-oxidative effects of adiponectin, and its effects on Kupffer cells recruitment and phenotype polarization. Augmentation of adiponectin effects could be a useful preventive approach for NASH progression.
C1 [Fukushima, Juichi; Kamada, Yoshihiro; Matsumoto, Hitoshi; Yoshida, Yuichi; Ezaki, Hisao; Takemura, Takayo; Saji, Yukiko; Igura, Takumi; Tsutsui, Shusaku; Kiso, Shinichi; Hayashi, Norio] Osaka Univ, Grad Sch Med, Dept Gastroenterol & Hepatol, Suita, Osaka 5650871, Japan.
   [Kihara, Shinji; Funahashi, Tohru; Shimomura, Iichiro] Osaka Univ, Grad Sch Med, Dept Metab Med, Suita, Osaka 5650871, Japan.
   [Tamura, Shinji] Minoh Municipal Hosp, Osaka, Japan.
C3 The University of Osaka; The University of Osaka
RP Kiso, S (corresponding author), Osaka Univ, Grad Sch Med, Dept Gastroenterol & Hepatol, 2-2 K1 Yamadaoka, Suita, Osaka 5650871, Japan.
EM kiso@gh.med.osaka-u.ac.jp
RI Kihara, Shinji/AAW-2015-2021; Kamada, Yoshihiro/H-3309-2019
OI Kamada, Yoshihiro/0000-0001-5485-902X
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NR 45
TC 81
Z9 86
U1 0
U2 16
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1386-6346
EI 1872-034X
J9 HEPATOL RES
JI Hepatol. Res.
PD JUL
PY 2009
VL 39
IS 7
BP 724
EP 738
DI 10.1111/j.1872-034X.2009.00509.x
PG 15
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 461QE
UT WOS:000267282800012
PM 19473437
DA 2025-06-11
ER

PT J
AU Johnson, AR
   Wilkerson, MD
   Sampey, BP
   Troester, MA
   Hayes, DN
   Makowski, L
AF Johnson, Amy R.
   Wilkerson, Matthew D.
   Sampey, Brante P.
   Troester, Melissa A.
   Hayes, D. Neil
   Makowski, Liza
TI Cafeteria diet-induced obesity causes oxidative damage in white adipose
SO BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
LA English
DT Article
DE Obesity; Inflammation; Oxidative stress; Genomics; Microarray; 4-HNE
ID ACID-BINDING PROTEIN; ENDOPLASMIC-RETICULUM STRESS; METABOLIC SYNDROME;
   INSULIN-RESISTANCE; HIGH-FAT; INFLAMMATION; CELLS; EXPRESSION; MOUSE;
   IDENTIFICATION
AB Obesity continues to be one of the most prominent public health dilemmas in the world. The complex interaction among the varied causes of obesity makes it a particularly challenging problem to address. While typical high-fat purified diets successfully induce weight gain in rodents, we have described a more robust model of diet-induced obesity based on feeding rats a diet consisting of highly palatable, energy-dense human junk foods the "cafeteria" diet (CAF, 45-53% kcal from fat). We previously reported that CAF-fed rats became hyperphagic, gained more weight, and developed more severe hyper-insulinemia, hyperglycemia, and glucose intolerance compared to the lard-based 45% kcal from fat high fat diet fed group. In addition, the CAF diet-fed group displayed a higher degree of inflammation in adipose and liver, mitochondrial dysfunction, and an increased concentration of lipid-derived, pro-inflammatory mediators. Building upon our previous findings, we aimed to determine mechanisms that underlie physiologic findings in the CAF diet. We investigated the effect of CAF diet-induced obesity on adipose tissue specifically using expression arrays and immunohistochemistry. Genomic evidence indicated the CAF diet induced alterations in the white adipose gene transcriptome, with notable suppression of glutathione-related genes and pathways involved in mitigating oxidative stress. Immunohistochemical analysis indicated a doubling in adipose lipid peroxidation marker 4-HNE levels compared to rats that remained lean on control standard chow diet. Our data indicates that the CAF diet drives an increase in oxidative damage in white adipose tissue that may affect tissue homeostasis. Oxidative stress drives activation of inflammatory kinases that can perturb insulin signaling leading to glucose intolerance and diabetes. (C) 2016 Elsevier Inc. All rights reserved.
C1 [Johnson, Amy R.; Sampey, Brante P.; Makowski, Liza] Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Nutr, Chapel Hill, NC 27599 USA.
   [Wilkerson, Matthew D.; Hayes, D. Neil] Univ N Carolina, Sch Med, Chapel Hill, NC 27599 USA.
   [Wilkerson, Matthew D.; Makowski, Liza] Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA.
   [Troester, Melissa A.] Univ N Carolina, Dept Epidemiol, Chapel Hill, NC 27599 USA.
   [Hayes, D. Neil] Univ N Carolina, Div Hematol & Oncol, Dept Med, Chapel Hill, NC 27599 USA.
   [Hayes, D. Neil] Univ N Carolina, Dept Otolaryngol Head & Neck Surg, Chapel Hill, NC 27599 USA.
   [Johnson, Amy R.] Agilent Technol, Seahorse Biosci, Santa Clara, CA USA.
   [Wilkerson, Matthew D.] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA.
   [Sampey, Brante P.] Roivant Sci Inc, Roviant, NC USA.
C3 University of North Carolina; University of North Carolina Chapel Hill;
   University of North Carolina; University of North Carolina Chapel Hill;
   University of North Carolina School of Medicine; University of North
   Carolina; University of North Carolina Chapel Hill; University of North
   Carolina; University of North Carolina Chapel Hill; University of North
   Carolina; University of North Carolina Chapel Hill; University of North
   Carolina; University of North Carolina Chapel Hill; Agilent
   Technologies; Uniformed Services University of the Health Sciences - USA
RP Makowski, L (corresponding author), Univ N Carolina, Dept Nutr, CB 7461, Chapel Hill, NC 27599 USA.
EM liza.makowski@unc.edu
RI Hayes, D/AIA-2263-2022; Makowski, Liza/B-8062-2012; Wilkerson,
   Matthew/KRQ-6581-2024
OI Makowski, Liza/0000-0002-5337-8037; Wilkerson,
   Matthew/0000-0003-2727-0230; Sampey, Brante/0000-0001-7765-0667
FU UNC University Cancer Research Fund [NIH AA017376]; UNC Nutrition
   Obesity Research Consortium [NIH P30DK056350];  [NIH F32H117616]
FX We acknowledge the support of Dr. Amanda M. Vanhoose, Ph.D. and Ms.
   Helena Winfield in assisting with rat experiments. ARJ was supported by
   NIH F32H117616. LM, MM, and DNH were supported by UNC University Cancer
   Research Fund, NIH AA017376; LM and MT were supported by the UNC
   Nutrition Obesity Research Consortium (NIH P30DK056350).
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NR 47
TC 37
Z9 41
U1 0
U2 11
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0006-291X
EI 1090-2104
J9 BIOCHEM BIOPH RES CO
JI Biochem. Biophys. Res. Commun.
PD APR 29
PY 2016
VL 473
IS 2
BP 545
EP 550
DI 10.1016/j.bbrc.2016.03.113
PG 6
WC Biochemistry & Molecular Biology; Biophysics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics
GA DK3IG
UT WOS:000374809700028
PM 27033600
OA Green Submitted, Green Accepted
DA 2025-06-11
ER

PT J
AU Kathuria, S
   Mahadevan, N
   Balakumar, P
AF Kathuria, Sonam
   Mahadevan, Nanjaian
   Balakumar, Pitchai
TI Possible involvement of PPARγ-associated eNOS signaling activation in
   rosuvastatin-mediated prevention of nicotine-induced experimental
   vascular endothelial abnormalities
SO MOLECULAR AND CELLULAR BIOCHEMISTRY
LA English
DT Article
DE Nicotine; Vascular endothelial dysfunction; Rosuvastatin; PPAR gamma;
   eNOS; Nitric oxide; Vascular protection
ID COA REDUCTASE INHIBITOR; NITRIC-OXIDE PRODUCTION; RECEPTOR-GAMMA;
   OXIDATIVE STRESS; METABOLIC SYNDROME; DYSFUNCTION; SMOKING;
   INFLAMMATION; PHOSPHORYLATION; HYPERTENSION
AB Nicotine exposure via cigarette smoking and tobacco chewing is associated with vascular complications. The present study investigated the effect of rosuvastatin in nicotine (2 mg/kg/day, i.p., 4 weeks)-induced vascular endothelial dysfunction (VED) in rats. The development of VED was assessed by employing isolated aortic ring preparation and estimating aortic and serum nitrite/nitrate concentration. Further, scanning electron microscopy and hematoxylin-eosin staining of thoracic aorta were performed to assess the vascular endothelial integrity. Moreover, oxidative stress was assessed by estimating aortic superoxide anion generation and serum thiobarbituric acid-reactive substances. The nicotine administration produced VED by markedly reducing acetylcholine-induced endothelium-dependent relaxation, impairing the integrity of vascular endothelium, decreasing aortic and serum nitrite/nitrate concentration, increasing oxidative stress, and inducing lipid alteration. However, treatment with rosuvastatin (10 mg/kg/day, i.p., 4 weeks) markedly attenuated nicotine-induced vascular endothelial abnormalities, oxidative stress, and lipid alteration. Interestingly, the co-administration of peroxisome proliferator-activated receptor gamma (PPAR gamma) antagonist, GW9662 (1 mg/kg/day, i.p., 2 weeks) submaximally, significantly prevented rosuvastatin-induced improvement in vascular endothelial integrity, endothelium-dependent relaxation, and nitrite/nitrate concentration in rats administered nicotine. However, GW9662 co-administration did not affect rosuvastatin-associated vascular anti-oxidant and lipid-lowering effects. The incubation of aortic ring, isolated from rosuvastatin-treated nicotine-administered rats, with L-NAME (100 mu M), an inhibitor of nitric oxide synthase (NOS), significantly attenuated rosuvastatin-induced improvement in acetylcholine-induced endothelium-dependent relaxation. Rosuvastatin prevents nicotine-induced vascular endothelial abnormalities by activating PPAR gamma and endothelial NOS signaling pathways. Moreover, the PPAR gamma-independent anti-oxidant and lipid-lowering effects of rosuvastatin might additionally play a role in the improvement of vascular endothelial function.
C1 [Kathuria, Sonam; Balakumar, Pitchai] Rajendra Inst Technol & Sci, Cardiovasc Pharmacol Div, Dept Pharmacol, Sirsa 125055, India.
   [Mahadevan, Nanjaian] Rajendra Inst Technol & Sci, Inst Pharm, Sirsa 125055, India.
RP Balakumar, P (corresponding author), Rajendra Inst Technol & Sci, Cardiovasc Pharmacol Div, Dept Pharmacol, Sirsa 125055, India.
EM pbala2006@gmail.com
RI Balakumar, Pitchai/IVV-0100-2023
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NR 59
TC 14
Z9 14
U1 0
U2 16
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0300-8177
EI 1573-4919
J9 MOL CELL BIOCHEM
JI Mol. Cell. Biochem.
PD FEB
PY 2013
VL 374
IS 1-2
BP 61
EP 72
DI 10.1007/s11010-012-1505-6
PG 12
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA 062QR
UT WOS:000312936500007
PM 23149826
DA 2025-06-11
ER

PT J
AU Winkelmann, BR
   Boehm, BO
   Nauck, M
   Kleist, P
   März, W
   Verhoe, NK
   Ranjith, N
   Kneissl, G
AF Winkelmann, BR
   Boehm, BO
   Nauck, M
   Kleist, P
   März, W
   Verhoe, NK
   Ranjith, N
   Kneissl, G
TI Cigarette smoking is independently associated with markers of
   endothelial dysfunction and hyperinsulinaemia in non-diabetic
   individuals with coronary artery disease
SO CURRENT MEDICAL RESEARCH AND OPINION
LA English
DT Article
DE cigarette smoking; endothelial dysfunction; cell adhesion molecule;
   hyperinsulinaemia; insulin resistance; coronary artery disease
ID INSULIN-RESISTANCE SYNDROME; DEPENDENT VASCULAR RELAXATION;
   PLASMA-INSULIN; RISK FACTOR; LIPOPROTEIN CONCENTRATIONS;
   CARDIOVASCULAR-DISEASE; ESSENTIAL-HYPERTENSION; HEART-DISEASE;
   VITAMIN-C; SMOKERS
AB Background, Oxidative stress and endothelial dysfunction have been introduced as a unifying pathological mechanism for early atherosclerotic disease. They are caused by a variety of stimuli including cigarette smoking (environmental) and type 2 diabetes (disease factor), However, the role of hyperinsulininaemia, a marker of insulin resistance, as a risk factor for atherosclerosis remains to be clarified.
   Study objectives: To study the relationship of smoking, hyperinsulinaemia and biochemical markers of oxidative stress and endothelial dysfunction, in patients with coronary artery disease.
   Design: Case-control study of 5-year survivor status in smokers, former smokers and nonsmokers with angiographically documented stable coronary artery disease classified by self-reporting of smoking status together with plasma cotinine measurements.
   Setting: Cardiology and cardiac surgery unit of a tertiary care referral centre.
   Patients and methods: Plasma levels of vitamins C, E and selenium, and the adhesion molecules E-selectin, intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) were assessed In 214 patients at baseline together with the glucose and insulin response to an oral glucose challenge. Sixty known or newly diagnosed type 2 diabetic patients (28%) were identified and excluded from further analysis.
   Results: E-selectin and ICAM-1, serving as markers of endothelial dysfunction, significantly correlated with hyperinsulinaemia (p < 0.5). Circulating immunoreactive insulin was elevated in active smokers and former smokers as compared to non-smokers after an oral glucose load (p < 0.05 for the area under the insulin time curve), despite a similar glucose response, Smoking was associated with a decrease in antioxidant vitamins C (p = 0.02) and E (p =0.03), and an increase of E-selectin (p < 0.05) and ICAM-1 (p < 0.001), Low baseline ICAM-1 and high vitamin C levels emerged as the most significant multivariate predictors of 5-year survival (p < 0.001).
   Conclusions: Hyperinsulinaemia in smokers Is linked with markers of endothelial dysfunction. Impaired vascular reactivity can thus be a new possible mechanism linking insulin resistance and smoking.
C1 Univ Klinikum Heidelberg, Kooperat Einheit Pharmakogenom Angew Genomforsch, D-69120 Heidelberg, Germany.
   Univ Ulm Klinikum, Sekt Endokrinol, Ulm, Germany.
   Univ Freiburg Klinikum, Freiburg, Germany.
   Novartis Pharma Schweiz AG, Dept Med, Bern, Switzerland.
   Univ Vienna, A-1010 Vienna, Austria.
   Kardiol Gemeinschaftspraxis, Leipzig, Germany.
C3 Ruprecht Karls University Heidelberg; Ulm University; University of
   Freiburg; Novartis; University of Vienna
RP Winkelmann, BR (corresponding author), Univ Klinikum Heidelberg, Kooperat Einheit Pharmakogenom Angew Genomforsch, Neuenheimer Feld 221, D-69120 Heidelberg, Germany.
RI Boehm, Bernhard/F-8750-2015; Nauck, Michael/AFN-4131-2022
OI Nauck, Michael Albrecht/0000-0002-5749-6954
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NR 53
TC 35
Z9 38
U1 1
U2 1
PU LIBRAPHARM
PI NEWBURY
PA C/O DR. PETER L CLARKE, GEMINI HOUSE, 162 CRAVEN RD, NEWBURY RG14 5NR,
   BERKSHIRE, ENGLAND
SN 0300-7995
J9 CURR MED RES OPIN
JI Curr. Med. Res. Opin.
PY 2001
VL 17
IS 2
BP 132
EP 141
DI 10.1185/0300799039117049
PG 10
WC Medicine, General & Internal; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Research & Experimental Medicine
GA 489YD
UT WOS:000172019800011
PM 11759183
DA 2025-06-11
ER

PT J
AU Khanaghaei, M
   Ziamajidi, N
   Poorolajal, J
   Asadikaram, G
   Nikoyan, P
   Bajian, M
   Abbasalipourkabir, R
AF Khanaghaei, Masouod
   Ziamajidi, Nasrin
   Poorolajal, Jalal
   Asadikaram, Gholamreza
   Nikoyan, Payam
   Bajian, Mohammadhosein
   Abbasalipourkabir, Roghayeh
TI The influence of gastric bypass surgery on the concentration of high
   mobility group box 1, nuclear factor erythroid 2-related factor 2 and
   the genes expression of high mobility group box 1, nuclear factor
   erythroid2-related factor 2, interleukin 6, and tumor necrosis
   factor-alpha in the peripheral blood mononuclear cells of patients with
   morbid obesity
SO MOLECULAR BIOLOGY REPORTS
LA English
DT Article
DE Morbid obesity; Oxidative stress; Surgery; High mobility group box 1;
   Nuclear factor erythroid2-related factor 2
ID GROUP PROTEIN B1; OXIDATIVE STRESS; METABOLIC SYNDROME; BARIATRIC
   SURGERY; INFLAMMATION; FAT; HMGB1; ACCUMULATION; ASSOCIATION; MECHANISMS
AB Background and objectives Obesity is known as a disease with a chronic low-grade state of inflammation and high levels of oxidative stress. Given the challenges and consequences caused by obesity, obesity therapy is an essential subject to address. For sustainable weight loss, gastric bypass surgery is the most successful and essential option. Methods This prospective cohort study was performed on 35 patients aged (18-54) with morbid obesity (BMI: 42.06 kg/m(2)). Volunteers blood was taken, and peripheral blood mononuclear cells (PBMCs) were isolated, high mobility group box 1(HMGB1), nuclear factor erythroid2-related factor 2(Nrf2), Interleukin 6(IL-6), tumor necrosis factor-alpha (TNF-alpha), and biochemical factors were determined one day before and 4 months after surgery. Results Four months following surgery, the BMI, hip and waist circumferences, and waist-to-hip ratio (WHR) all decreased significantly. The lipid profile and antioxidant power were dramatically enhanced after surgery. IL-6 and TNF-alpha expression in PBMC patients showed a significant decrease after surgery. HMGB1 and Nrf2 expression in PBMC of postoperative patients decreased compared to before surgery, and HMGB1, and Nrf2 protein levels also decreased after surgery. Conclusion Weight loss indicated the significant function of adipose tissue in the induction of oxidative stress and inflammatory factors. Gastric bypass reduced the inflammation conditions and improved the metabolic status and living situations in the patients with morbid obesity.
C1 [Khanaghaei, Masouod; Ziamajidi, Nasrin; Abbasalipourkabir, Roghayeh] Hamadan Univ Med Sci, Sch Med, Dept Biochem, Hamadan, Hamadan, Iran.
   [Poorolajal, Jalal] Hamadan Univ Med Sci, Sch Hlth, Dept Epidemiol, Hamadan, Hamadan, Iran.
   [Asadikaram, Gholamreza] Kerman Univ Med Sci, Sch Med, Dept Biochem & Nutr, Kerman, Iran.
   [Nikoyan, Payam; Bajian, Mohammadhosein] Kerman Univ Med Sci, Kerman Mehregan Bariatr Surg Ctr, Kerman, Iran.
C3 Hamadan University of Medical Sciences; Hamadan University of Medical
   Sciences; Kerman University of Medical Sciences; Kerman University of
   Medical Sciences
RP Abbasalipourkabir, R (corresponding author), Hamadan Univ Med Sci, Sch Med, Dept Biochem, Hamadan, Hamadan, Iran.
EM rpourkabir@hotmail.com
RI Abbasalipourkabir, Roghayeh/P-8563-2017; Poorolajal, Jalal/D-3506-2013;
   Asadikaram, Gholamreza/AAG-4437-2021; Ziamajidi, Nasrin/O-9101-2019
OI Asadikaram, Gholamreza/0000-0002-9100-0756
FU Hamadan University of Medical Sciences, Iran [9811158686]
FX This report was taken from a PhD thesis at Hamadan University of Medical
   Sciences, Iran<BOLD>.</BOLD> The research was funded by Vice-chancellor
   for Research and Technology, Hamadan University of Medical Sciences,
   Iran (No. 9811158686).
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NR 49
TC 4
Z9 4
U1 0
U2 2
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0301-4851
EI 1573-4978
J9 MOL BIOL REP
JI Mol. Biol. Rep.
PD MAY
PY 2022
VL 49
IS 5
BP 3745
EP 3755
DI 10.1007/s11033-022-07214-6
EA FEB 2022
PG 11
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 1X7LZ
UT WOS:000750401300008
PM 35107739
DA 2025-06-11
ER

PT J
AU Wikstrom, J
   Liu, YQ
   Whatling, C
   Gan, LM
   Konings, P
   Mao, BC
   Zhang, C
   Ji, YQ
   Xiao, YF
   Wang, YX
AF Wikstrom, Johannes
   Liu, Yongqiang
   Whatling, Carl
   Gan, Li-ming
   Konings, Peter
   Mao, Binchen
   Zhang, Chao
   Ji, Yanqin
   Xiao, Yong-Fu
   Wang (Jim), Yixin
TI Diastolic dysfunction and impaired cardiac output reserve in
   dysmetabolic nonhuman primate with proteinuria
SO JOURNAL OF DIABETES AND ITS COMPLICATIONS
LA English
DT Article
DE Diabetic complications; Cardiorenal dysfunction; Metabolic syndrome;
   Monkey model; Dobutamine stress test; Echocardiography
ID STRESS ECHOCARDIOGRAPHY; FUNCTIONAL RESERVE; EJECTION FRACTION;
   HEART-FAILURE; DOBUTAMINE; DISEASE; VOLUME; MODEL
AB Background: Cardiorenal complications are common in patients with dysmetabolism and diabetes. The present study aimed to examine if a nonhuman primate (NHP) model with spontaneously developed metabolic disorder and diabetes develops similar complications to humans, such as proteinuria and cardiac dysfunction at resting condition or diminished cardiac functional reserve following dobutamine stress echocardiography (DSE).
   Methods and results: A total of 66 dysmetabolic and diabetic cynomolgus (Macaca fascicularis) NHPs were enrolled to select 19 NHPs (MetS) with marked metabolic disorders and diabetes (fasting blood glucose: 178 +/- 18 vs. 61 +/- 3 mg/dL) accompanied by proteinuria (ACR: 134 +/- 34 vs. 1.5 +/- 0.4 mg/mmol) compared to 8 normal NHPs (CTRL). Under resting condition, MetS NHPs showed mild left ventricular (LV) diastolic dysfunction (E/A: 1 +/- 0.06 vs. 1.5 +/- 0.13), butwith preserved ejection fraction (EF: 65 +/- 2 vs. 71 +/- 3%) compared to CTRL. DSE with an intravenous infusion of dobutamine at ascending doses (5, 10, 20, 30 and 40 mu g/kg/min, 7 min for each dose) resulted in a dose-dependent increase in cardiac function, however, with a significantly diminished magnitude at the highest dose of dobutamine infusion (40 mu g/kg/min) in both diastole (E/A:-12 +/- 3 vs.-38 +/- 5%) and systole (EF: 25 +/- 3 vs. 33 +/- 5%) as well as similar to 42% reduced cardiac output reserve (COR: 63 +/- 8 vs. 105 +/- 18%, p < 0.02) in the MetS compared to CTRL NHPs.
   Conclusion: These data demonstrate that MetS NHPs with cardiorenal complications: proteinuria, LV diastolic dysfunction and preserved LV systolic function under resting conditions displayed compromised cardiac functional reserve under dobutamine stress. Based on these phenotypes, this NHP model of diabetes with cardiorenal complications can be used as a highly translational model mimic human disease for pharmaceutical research. (c) 2021 Elsevier Inc. All rights reserved.
C1 [Wikstrom, Johannes] AstraZeneca, Res & Early Dev, Cardiovasc Renal & Metab, BioPharmaceut R&D,Biosci, Gothenburg, Sweden.
   [Whatling, Carl] AstraZeneca, Translat Sci & Expt Med, Res & Early Dev, Cardiovasc Renal & Metab,BioPharmaceut R&D, Gothenburg, Sweden.
   [Gan, Li-ming] AstraZeneca, Res & Early Dev, Res & Early Dev, Cardiovasc Renal & Metab,BioPharmaceut R&D, Gothenburg, Sweden.
   [Konings, Peter] AstraZeneca, Quantitat Biol, Discovery Sci, R&D, Gothenburg, Sweden.
   [Liu, Yongqiang; Mao, Binchen; Zhang, Chao; Ji, Yanqin; Xiao, Yong-Fu; Wang (Jim), Yixin] Crown Biosci Inc, 6 West Beijing Rd, Taicang, Jiangsu, Peoples R China.
C3 AstraZeneca; AstraZeneca; AstraZeneca; AstraZeneca
RP Wikstrom, J (corresponding author), AstraZeneca, Res & Early Dev, Cardiovasc Renal & Metab, BioPharmaceut R&D,Biosci, Gothenburg, Sweden.; Wang, YX (corresponding author), Crown Biosci Inc, 6 West Beijing Rd, Taicang, Jiangsu, Peoples R China.
EM Johannes.Wikstrom@astrazeneca.com; YXWANG2000@gmail.com
RI Li, Fuyu/JXL-1414-2024
OI Konings, Peter/0000-0002-8637-5916
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NR 44
TC 5
Z9 5
U1 0
U2 4
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1056-8727
EI 1873-460X
J9 J DIABETES COMPLICAT
JI J. Diabetes Complications
PD APR
PY 2021
VL 35
IS 4
AR 107881
DI 10.1016/j.jdiacomp.2021.107881
EA MAR 2021
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA QT3HB
UT WOS:000626479600013
PM 33612386
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Odegaard, AO
   Jacobs, DR
   Sanchez, OA
   Goff, DC
   Reiner, AP
   Gross, MD
AF Odegaard, Andrew O.
   Jacobs, David R., Jr.
   Sanchez, Otto A.
   Goff, David C., Jr.
   Reiner, Alexander P.
   Gross, Myron D.
TI Oxidative stress, inflammation, endothelial dysfunction and incidence of
   type 2 diabetes
SO CARDIOVASCULAR DIABETOLOGY
LA English
DT Article
DE Young adults; oxidative stress; Inflammation; Endothelial dysfunction;
   Incidence; Type 2 diabetes
ID ARTERY RISK DEVELOPMENT; LOW-DENSITY-LIPOPROTEIN; YOUNG-ADULTS CARDIA;
   CIRCULATING CAROTENOID CONCENTRATIONS; INTERCELLULAR-ADHESION
   MOLECULE-1; CARDIOVASCULAR-DISEASE; INSULIN-RESISTANCE; ATHEROSCLEROSIS
   RISK; POSTMENOPAUSAL WOMEN; OLDER-ADULTS
AB Background: Oxidative stress, inflammation and endothelial dysfunction are interrelated factors in the etiology of cardiovascular disease, but their linkage to type 2 diabetes is less clear. We examined the association of these biomarkers with incident type 2 diabetes (T2D).
   Methods: Analysis of 2339 participants in the community-based coronary artery risk development in young adults (CARDIA) study. Participants (age 40.1 +/- 3.6 years, 44 % Black, 58 % women) were free of diabetes, and were followed 10 years. Cox regression was used to estimate hazard ratios (HRs) for incident T2D adjusting for the other biomarkers under study, demographic and lifestyle measures, dietary biomarkers, BMI (kg/m(2)) and metabolic syndrome components.
   Results: F2-isoprostanes and oxidized LDL (oxidative stress) were positively associated with incident T2D, but the associations were attenuated by adjustment for BMI. C-reactive protein was positively associated with T2D even with full adjustment: HR (95 % CI) = 2.21 (1.26-3.88) for quartile 4 (Q4) v. quartile 1 (Q1). The HR (95 % CI) for T2D for biomarkers of endothelial dysfunction ICAM-1 and E-selectin for Q4 v. Q1 were 1.64 (0.96-2.81) and 1.68 (1.04-2.71) respectively, with full adjustment. Including these two markers in a common risk score incorporating BMI and clinical measures improved the prediction probability of T2D: relative risk for the average person classified up compared to the average person classified down: 1.09, (1.06-1.13), P < 0.0001.
   Conclusions: Biomarkers of inflammation and endothelial dysfunction were positively associated with incident T2D. ICAM-1 and E-selectin add to the prediction of T2D beyond a common risk score.
C1 [Odegaard, Andrew O.] Univ Calif Irvine, Sch Med, Dept Epidemiol, Irvine, CA 92697 USA.
   [Jacobs, David R., Jr.; Sanchez, Otto A.; Gross, Myron D.] Univ Minnesota, Sch Publ Hlth, Div Epidemiol & Community Hlth, Minneapolis, MN USA.
   [Goff, David C., Jr.] Univ Colorado, Colorado Sch Publ Hlth, Dept Epidemiol, Denver, CO 80202 USA.
   [Reiner, Alexander P.] Univ Washington, Sch Publ Hlth, Dept Epidemiol, Seattle, WA 98195 USA.
   [Gross, Myron D.] Univ Minnesota, Sch Med, Dept Lab Med & Pathol, Minneapolis, MN 55455 USA.
C3 University of California System; University of California Irvine;
   University of Minnesota System; University of Minnesota Twin Cities;
   University of Colorado System; University of Colorado Denver; Colorado
   School of Public Health; University of Washington; University of
   Washington Seattle; University of Minnesota System; University of
   Minnesota Twin Cities
RP Odegaard, AO (corresponding author), Univ Calif Irvine, Sch Med, Dept Epidemiol, Irvine, CA 92697 USA.
EM aodegaar@uci.edu
RI Sanchez, Otto/AAM-1473-2021; Jacobs, David/G-5405-2011
OI Jacobs, David/0000-0002-7232-0543
FU National Heart, Lung, and Blood Institute (NHLBI); University of Alabama
   at Birmingham [HHSN268201300025C, HHSN268201300026C]; Northwestern
   University [HHSN268201300027C]; University of Minnesota
   [HHSN268201300028C]; Kaiser Foundation Research Institute
   [HHSN268201300029C]; Johns Hopkins University School of Medicine
   [HHSN268200900041C]; Intramural Research Program of the National
   Institute on Aging (NIA); NIA [AG0005]; NHLBI [AG0005];  [RO1-HL-53560]
FX The coronary artery risk development in young adults study (CARDIA) is
   conducted and supported by the National Heart, Lung, and Blood Institute
   (NHLBI) in collaboration with the University of Alabama at Birmingham
   (HHSN268201300025C and HHSN268201300026C), Northwestern University
   (HHSN268201300027C), University of Minnesota (HHSN268201300028C), Kaiser
   Foundation Research Institute (HHSN268201300029C), and Johns Hopkins
   University School of Medicine (HHSN268200900041C). CARDIA is also
   partially supported by the Intramural Research Program of the National
   Institute on Aging (NIA) and an intra-agency agreement between NIA and
   NHLBI (AG0005). The YALTA study was supported by the grant RO1-HL-53560.
   This manuscript has been reviewed by CARDIA for scientific content.
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NR 50
TC 218
Z9 233
U1 1
U2 22
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1475-2840
J9 CARDIOVASC DIABETOL
JI Cardiovasc. Diabetol.
PD MAR 24
PY 2016
VL 15
AR 51
DI 10.1186/s12933-016-0369-6
PG 12
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism
GA DH4GP
UT WOS:000372743800001
PM 27013319
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Pung, YF
   Sam, WJ
   Stevanov, K
   Enrick, M
   Chen, CL
   Kolz, C
   Thakker, P
   Hardwick, JP
   Chen, YR
   Dyck, JRB
   Yin, L
   Chilian, WM
AF Pung, Yuh Fen
   Sam, Wai Johnn
   Stevanov, Kelly
   Enrick, Molly
   Chen, Chwen-Lih
   Kolz, Christopher
   Thakker, Prashanth
   Hardwick, James P.
   Chen, Yeong-Renn
   Dyck, Jason R. B.
   Yin, Liya
   Chilian, William M.
TI Mitochondrial Oxidative Stress Corrupts Coronary Collateral Growth by
   Activating Adenosine Monophosphate Activated Kinase- Signaling
SO ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
LA English
DT Article
DE collateral circulation; coronary circulation; mitochondria; reactive
   oxygen species
ID PROTEIN-KINASE; METABOLIC SYNDROME; ENDOTHELIAL DYSFUNCTION;
   MORPHOMETRIC-ANALYSIS; HYDROGEN-PEROXIDE; HYPERTROPHY; RATS; MECHANISMS;
   HEALTH; OXYGEN
AB Objective
   Our goal was to determine the mechanism by which mitochondrial oxidative stress impairs collateral growth in the heart.
   Approach and Results
   Rats were treated with rotenone (mitochondrial complex I inhibitor that increases reactive oxygen species production) or sham-treated with vehicle and subjected to repetitive ischemia protocol for 10 days to induce coronary collateral growth. In control rats, repetitive ischemia increased flow to the collateral-dependent zone; however, rotenone treatment prevented this increase suggesting that mitochondrial oxidative stress compromises coronary collateral growth. In addition, rotenone also attenuated mitochondrial complex I activity and led to excessive mitochondrial aggregation. To further understand the mechanistic pathway(s) involved, human coronary artery endothelial cells were treated with 50 ng/mL vascular endothelial growth factor, 1 mu mol/L rotenone, and rotenone/vascular endothelial growth factor for 48 hours. Vascular endothelial growth factor induced robust tube formation; however, rotenone completely inhibited this effect (P<0.05 rotenone versus vascular endothelial growth factor treatment). Inhibition of tube formation by rotenone was also associated with significant increase in mitochondrial superoxide generation. Immunoblot analyses of human coronary artery endothelial cells with rotenone treatment showed significant activation of adenosine monophosphate activated kinase (AMPK)- and inhibition of mammalian target of rapamycin and p70 ribosomal S6 kinase. Activation of AMPK- suggested impairments in energy production, which was reflected by decrease in O-2 consumption and bioenergetic reserve capacity of cultured cells. Knockdown of AMPK- (siRNA) also preserved tube formation during rotenone, suggesting the negative effects were mediated by the activation of AMPK-. Conversely, expression of a constitutively active AMPK- blocked tube formation.
   Conclusions
   We conclude that activation of AMPK- during mitochondrial oxidative stress inhibits mammalian target of rapamycin signaling, which impairs phenotypic switching necessary for the growth of blood vessels.
C1 [Pung, Yuh Fen; Sam, Wai Johnn; Stevanov, Kelly; Enrick, Molly; Chen, Chwen-Lih; Kolz, Christopher; Thakker, Prashanth; Hardwick, James P.; Chen, Yeong-Renn; Yin, Liya; Chilian, William M.] Northeastern Ohio Univ Coll Med & Pharm, Dept Integrat Med Sci, Rootstown, OH 44272 USA.
   [Dyck, Jason R. B.] Univ Alberta, Dept Pediat, Fac Med & Dent, Cardiovasc Res Ctr, Edmonton, AB, Canada.
C3 University System of Ohio; Northeast Ohio Medical University (NEOMED);
   University of Alberta
RP Chilian, WM (corresponding author), Northeastern Ohio Univ Coll Med & Pharm, Dept Integrat Med Sci, Rootstown, OH 44272 USA.
EM wchilian@neomed.edu
RI Thompson, Richard/E-9821-2011; Pung, Yuh Fen/E-8959-2016
OI Dyck, Jason/0000-0002-7045-2884; Pung, Yuh Fen/0000-0001-6195-3970;
   Stevanov, Kelly/0000-0003-0911-0671
FU National Institute of Health [HL32788, HL83366, RC1HL100828, HL115540];
   American Heart Association [09POST2290021]; Canadian Institute of Health
   Research; Direct For Social, Behav & Economic Scie; Division Of
   Behavioral and Cognitive Sci [0959438] Funding Source: National Science
   Foundation; American Heart Association (AHA) [09POST2290021] Funding
   Source: American Heart Association (AHA)
FX This work was supported by National Institute of Health grants HL32788,
   HL83366, RC1HL100828 (to W.M. Chilian), HL115540 (to L. Yin), by an
   American Heart Association Post-doctoral Fellowship 09POST2290021 (to
   Y.F. Pung) and from the Canadian Institute of Health Research to J.R.B.
   Dyck. J.R.B. Dyck is an Alberta Heritage Foundation for Medical Research
   Scholar.
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NR 37
TC 27
Z9 30
U1 0
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1079-5642
EI 1524-4636
J9 ARTERIOSCL THROM VAS
JI Arterioscler. Thromb. Vasc. Biol.
PD AUG
PY 2013
VL 33
IS 8
BP 1911
EP 1919
DI 10.1161/ATVBAHA.113.301591
PG 9
WC Hematology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Hematology; Cardiovascular System & Cardiology
GA 188IW
UT WOS:000322187600027
PM 23788766
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Ning, J
   Hong, T
   Yang, XF
   Mei, S
   Liu, ZQ
   Liu, HY
   Cao, WH
AF Ning, Jie
   Hong, Tao
   Yang, Xuefeng
   Mei, Shuang
   Liu, Zhenqi
   Liu, Hui-Yu
   Cao, Wenhong
TI Insulin and insulin signaling play a critical role in fat induction of
   insulin resistance in mouse
SO AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
LA English
DT Article
DE fatty acid; long-chain acyl-CoA synthetase; obesity; diabetes
ID ACYL-COA SYNTHETASE; ACTIVATED PROTEIN-KINASE; ADENINE-NUCLEOTIDE
   TRANSLOCATION; OXIDATIVE STRESS; MITOCHONDRIAL DYSFUNCTION; REVERSIBLE
   INHIBITION; PRIMARY HEPATOCYTES; METABOLIC SYNDROME; HEPATIC STEATOSIS;
   SKELETAL-MUSCLE
AB Ning J, Hong T, Yang X, Mei S, Liu Z, Liu H, Cao W. Insulin and insulin signaling play a critical role in fat induction of insulin resistance in mouse. Am J Physiol Endocrinol Metab 301: E391-E401, 2011. First published May 17, 2011; doi:10.1152/ajpendo.00164.2011.-The primary player that induces insulin resistance has not been established. Here, we studied whether or not fat can cause insulin resistance in the presence of insulin deficiency. Our results showed that high-fat diet (HFD) induced insulin resistance in C57BL/6 (B6) mice. The HFD-induced insulin resistance was prevented largely by the streptozotocin (STZ)-induced moderate insulin deficiency. The STZ-induced insulin deficiency prevented the HFD-induced ectopic fat accumulation and oxidative stress in liver and gastrocnemius. The STZ-induced insulin deficiency prevented the HFD-or insulin-induced increase in hepatic expression of long-chain acyl-CoA synthetases (ACSL), which are necessary for fatty acid activation. HFD increased mitochondrial contents of long-chain acyl-CoAs, whereas it decreased mitochondrial ADP/ATP ratio, and these HFD-induced changes were prevented by the STZ-induced insulin deficiency. In cultured hepatocytes, we observed that expressions of ACSL1 and -5 were stimulated by insulin signaling. Results in cultured cells also showed that blunting insulin signaling by the PI3K inhibitor LY-294002 prevented fat accumulation, oxidative stress, and insulin resistance induced by the prolonged exposure to either insulin or oleate plus sera that normally contain insulin. Finally, knockdown of the insulin receptor prevented the oxidative stress and insulin resistance induced by the prolonged exposure to insulin or oleate plus sera. Together, our results show that insulin and insulin signaling are required for fat induction of insulin resistance in mice and cultured mouse hepatocytes.
C1 [Ning, Jie; Hong, Tao; Yang, Xuefeng; Mei, Shuang; Cao, Wenhong] Univ N Carolina, Dept Nutr, Gillings Sch Global Publ Hlth, Chapel Hill, NC 27559 USA.
   [Ning, Jie] 2nd Peoples Hosp Hunan Prov, Dept Endocrinol Metab, Changsha, Hunan, Peoples R China.
   [Yang, Xuefeng] Huazhong Univ Sci & Technol, Dept Food Hyg & Nutr, Tongji Med Coll, Wuhan 430074, Hubei, Peoples R China.
   [Hong, Tao] Univ S China, Affiliated Hosp 1, Hengyang, Hunan, Peoples R China.
   [Liu, Zhenqi] Univ Virginia Hlth Syst, Dept Med Endocrinol, Charlottesville, VA USA.
   [Liu, Hui-Yu] Hitech Dev Zone, Nanjing Moldepot Res & Dev, Nanjing, Jiangsu, Peoples R China.
   [Cao, Wenhong] Duke Univ, Dept Med Endocrinol Metab, Sch Med, Durham, NC USA.
C3 University of North Carolina; University of North Carolina Chapel Hill;
   Huazhong University of Science & Technology; University of South China;
   University of Virginia; University of Virginia (UVA) Health System; Duke
   University
RP Cao, WH (corresponding author), Univ N Carolina, Dept Nutr, Gillings Sch Global Publ Hlth, Chapel Hill, NC 27559 USA.
EM caow@unc.edu
RI Liu, Hui-Yu/D-1507-2009; Ning, Jie/LWK-1448-2024
FU American Diabetes Association [7-09-BS-27]; National Institute of
   Diabetes and Digestive and Kidney Diseases [R01-DK-076039]
FX This work was supported by grants from the American Diabetes Association
   (7-09-BS-27; to W. Cao) and the National Institute of Diabetes and
   Digestive and Kidney Diseases (R01-DK-076039; to W. Cao).
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NR 57
TC 31
Z9 33
U1 1
U2 17
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0193-1849
J9 AM J PHYSIOL-ENDOC M
JI Am. J. Physiol.-Endocrinol. Metab.
PD AUG
PY 2011
VL 301
IS 2
BP E391
EP E401
DI 10.1152/ajpendo.00164.2011
PG 11
WC Endocrinology & Metabolism; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Physiology
GA 811KZ
UT WOS:000294210200019
PM 21586696
OA Green Published
DA 2025-06-11
ER

PT J
AU de Lima, AMJ
   Franco, CMR
   de Castro, CMMB
   Bezerra, AD
   Ataide, L
   Halpern, A
AF Jaguaribe de Lima, Anna Myrna
   Ribeiro Franco, Clelia Maria
   Machado Barbosa de Castro, Celia Maria
   Bezerra, Alice de Andrade
   Ataide, Luiz, Jr.
   Halpern, Alfredo
TI Effects of Nasal Continuous Positive Airway Pressure Treatment on
   Oxidative Stress and Adiponectin Levels in Obese Patients with
   Obstructive Sleep Apnea
SO RESPIRATION
LA English
DT Article
DE Obstructive sleep apnea; Obesity; Oxidative stress; Adiponectin; Insulin
   resistance
ID HOMEOSTASIS MODEL ASSESSMENT; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   BLOOD-PRESSURE; NITRIC-OXIDE; THERAPY; HYPOXIA; GLUCOSE; LEPTIN; MEN
AB Background: Obesity and obstructive sleep apnea (OSA) are both associated with the prevalence of major cardiovascular illnesses and certain common factors they are considered responsible for, such as stress oxidative increase, sympathetic tonus and resistance to insulin. Objective: The aim of the present study was to compare the effect of continuous positive airway pressure (CPAP) on oxidative stress and adiponectin levels in obese patients with and without OSA. Methods: Twenty-nine obese patients were categorized into 3 groups: group 1: 10 individuals without OSA (apnea-hypopnea index, AHI <= 5) who did not have OSA diagnosed at polysomnography; group 2: 10 patients with moderate to severe OSA (AHI >= 20) who did not use CPAP; group 3: 9 patients with moderate to severe OSA (AHI >= 20) who used CPAP. Results: Group 3 showed significant differences before and after the use of CPAP, in the variables of diminished production of superoxide, and increased nitrite and nitrate synthesis and adiponectin levels. Positive correlations were seen between the AHI and the superoxide production, between the nitrite and nitrate levels and the adiponectin levels, between superoxide production and the HOMA-IR, and between AHI and the HOMA-IR. Negative correlations were found between AHI and the nitrite and nitrate levels, between the superoxide production and that of nitric oxide, between the superoxide production and the adiponectin levels, between AHI and the adiponectin levels, and between the nitrite and nitrate levels and the HOMA-IR. Conclusions: This study demonstrates that the use of CPAP can reverse the increased superoxide production, the diminished serum nitrite, nitrate and plasma adiponectin levels, and the metabolic changes existing in obese patients with OSA. Copyright (C) 2009 S. Karger AG, Basel
C1 [Jaguaribe de Lima, Anna Myrna] Rural Fed Univ Pernambuco, Recife, PE, Brazil.
   [Ribeiro Franco, Clelia Maria; Ataide, Luiz, Jr.] Univ Fed Pernambuco, Recife, PE, Brazil.
   [Machado Barbosa de Castro, Celia Maria; Bezerra, Alice de Andrade] Keizo Asami Immunopathol Lab LIKA, Recife, PE, Brazil.
   [Halpern, Alfredo] Univ Sao Paulo, Sao Paulo, Brazil.
C3 Universidade Federal Rural de Pernambuco (UFRPE); Universidade Federal
   de Pernambuco; Universidade de Sao Paulo
RP de Lima, AMJ (corresponding author), R Conego Romeu 176,Apto 301 Boa Viagem, BR-51030340 Recife, PE, Brazil.
EM annamyrna@uol.com.br
CR [Anonymous], SLEEP
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NR 40
TC 42
Z9 44
U1 1
U2 6
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0025-7931
EI 1423-0356
J9 RESPIRATION
JI Respiration
PY 2010
VL 79
IS 5
BP 370
EP 376
DI 10.1159/000227800
PG 7
WC Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Respiratory System
GA 557UW
UT WOS:000274696600004
PM 19590157
OA Bronze
DA 2025-06-11
ER

PT J
AU Zhou, RZ
   Wang, YX
   Chen, SY
   Cheng, FJ
   Yi, YH
   Lv, CH
   Qin, S
AF Zhou, Runze
   Wang, Yixue
   Chen, Shiyun
   Cheng, Fanjia
   Yi, Yuhang
   Lv, Chenghao
   Qin, Si
TI Anti-Inflammatory Effect of Dendrobium officinale Extract on
   High-Fat Diet-Induced Obesity in Rats: Involvement of Gut Microbiota,
   Liver Transcriptomics, and NF-κB/IκB Pathway
SO ANTIOXIDANTS
LA English
DT Article
DE Dendrobium officinale; oxidative stress; inflammation;
   gut microbiota; NF-kappa B/I kappa B pathway
ID OXIDATIVE STRESS; INFLAMMATION; METABOLISM; BARRIER; CELLS; ROS
AB The growing prevalence of obesity is being increasingly acknowledged as a major public health issue. This mainly stems from the excessive intake of dietary fats. Dendrobium officinale (DO), recognized as an herb with dual roles of food and medicine, is renowned for its diverse health-promoting effects. Nevertheless, the specifics of its antiobesity and anti-inflammatory properties and the underlying mechanisms are still obscure. The present study shows that treatment with Dendrobium officinale extract (DOE) alleviates obesity, liver steatosis, inflammation, and oxidative stress in rats that are obese due to a high-fat diet (HFD). Firstly, with respect to HFD obese rats, higher doses of DOE significantly reduced TG, TC, LDL-C, blood glucose, and liver AST and ALT, along with lipid droplets. Meanwhile, DOE supplementation significantly reduced oxidative stress induced by ROS and MDA and increased the levels of GSH-Px and SOD in liver tissues. Furthermore, integrated analysis of transcriptomic and microbiomic data revealed that DOE modulated inflammatory responses through the NF-kappa B/I kappa B pathway. This regulatory mechanism was evidenced by corresponding changes in the protein expression levels of both NF-kappa B and I kappa B. Additionally, DOE was found to modulate gut microbiota composition in obese rats, specifically reducing the relative abundance of Bilophila while increasing beneficial bacterial populations, particularly the genera Akkermansia and Roseburia. These findings suggest that DOE may help retain the homeostasis of the gut microbiota and improve metabolic health by regulating inflammation in the liver and intestine, thereby providing protection against obesity and related metabolic syndromes. Our study demonstrates that DOE, as a natural botanical extract, can effectively facilitate the prevention or treatment of metabolic syndrome through precision dietary interventions.
C1 [Zhou, Runze; Wang, Yixue; Chen, Shiyun; Cheng, Fanjia; Qin, Si] Hunan Agr Univ, Coll Food Sci & Technol, Changsha 410128, Peoples R China.
   [Yi, Yuhang] Hunan Agr Univ, Coll Biosci & Biotechnol, Changsha 410128, Peoples R China.
   [Lv, Chenghao] Cent South Univ, Xiangya Hosp, Inst Integrat Med, Hunan Prov Key Lab Liver Visceral Manifestat Tradi, Changsha 410008, Peoples R China.
C3 Hunan Agricultural University; Hunan Agricultural University; Central
   South University
RP Qin, S (corresponding author), Hunan Agr Univ, Coll Food Sci & Technol, Changsha 410128, Peoples R China.; Lv, CH (corresponding author), Cent South Univ, Xiangya Hosp, Inst Integrat Med, Hunan Prov Key Lab Liver Visceral Manifestat Tradi, Changsha 410008, Peoples R China.
EM zhourunze@stu.hunau.edu.cn; wangyixue@stu.hunau.edu.cn;
   shiyunchen0531@stu.hunau.edu.cn; chengfanjia@stu.hunau.edu.cn;
   yiyuhang@stu.hunau.edu.cn; lvchenghao@stu.hunau.edu.cn;
   qinsiman@hunau.edu.cn
RI Lv, Chenghao/ABO-9390-2022; zhou, runze/NBY-0295-2025
OI Zhou, Runze/0009-0009-9370-3592
FU Natural Science Foundation of Hunan Province; National Key Research and
   Development Program of China [2019YFC1604903]; Hunan Province
   Postgraduate Research and Innovation Project [CX20230685]; 
   [2023JJ30295]
FX This work was funded by the Natural Science Foundation of Hunan Province
   (2023JJ30295), the National Key Research and Development Program of
   China (2019YFC1604903) to Si Qin, and Hunan Province Postgraduate
   Research and Innovation Project (CX20230685) to Chenghao Lv.
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NR 51
TC 0
Z9 0
U1 1
U2 1
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD APR 3
PY 2025
VL 14
IS 4
AR 432
DI 10.3390/antiox14040432
PG 30
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA 1VN1W
UT WOS:001474650200001
PM 40298780
OA gold
DA 2025-06-11
ER

PT J
AU do Carmo, JM
   da Silva, AA
   Sessums, PO
   Ebaady, SH
   Pace, BR
   Rushing, JS
   Davis, MT
   Hall, JE
AF do Carmo, J. M.
   da Silva, A. A.
   Sessums, P. O.
   Ebaady, S. H.
   Pace, B. R.
   Rushing, J. S.
   Davis, M. T.
   Hall, J. E.
TI Role of Shp2 in forebrain neurons in regulating metabolic and
   cardiovascular functions and responses to leptin
SO INTERNATIONAL JOURNAL OF OBESITY
LA English
DT Article
DE energy expenditure; food intake; blood pressure; heart rate; acute
   stress; thermoneutrality
ID PROTEIN-TYROSINE-PHOSPHATASE; NERVOUS-SYSTEM; BLOOD-PRESSURE; OBESITY;
   MICE; ACTIVATION
AB OBJECTIVE: We examined whether deficiency of Src homology 2 containing phosphatase (Shp2) signaling in forebrain neurons alters metabolic and cardiovascular regulation under various conditions and if it attenuates the anorexic and cardiovascular effects of leptin. We also tested whether forebrain Shp2 deficiency alters blood pressure (BP) and heart rate (HR) responses to acute stress.
   DESIGN: Forebrain Shp2(-/-) mice were generated by crossing Shp2(flox/flox) mice with CamKII alpha-cre mice. At 22-24 weeks of age, the mice were instrumented for telemetry for measurement of BP, HR and body temperature (BT). Oxygen consumption (VO2), energy expenditure and motor activity were monitored by indirect calorimetry.
   RESULTS: Shp2/CamKII alpha-cre mice were heavier (46 +/- 3 vs 32 +/- 1 g), hyperglycemic, hyperleptinemic, hyperinsulinemic and hyperphagic compared to Shp2(flox/flox) control mice. Shp2/CamKII alpha-cre mice exhibited reduced food intake responses to fasting/refeeding and impaired regulation of BT when exposed to 15 and 30 degrees C ambient temperatures. Despite being obese and having many features of metabolic syndrome, Shp2/CamKII alpha-cre mice had similar daily average BP and HR compared to Shp2(flox/flox) mice (112 +/- 2 vs 113 +/- 1 mm Hg and 595 +/- 34 vs 650 +/- 40 b.p.m.), but exhibited increased BP and HR responses to cold exposure and acute air-jet stress test. Leptin's ability to reduce food intake and to raise BP were markedly attenuated in Shp2/CamKII alpha-cre mice.
   CONCLUSION: These results suggest that forebrain Shp2 signaling regulates food intake, appetite responses to caloric deprivation and thermogenic control of body temperature during variations in ambient temperature. Deficiency of Shp2 signaling in the forebrain is associated with augmented cardiovascular responses to cold and acute stress but attenuated BP responses to leptin.
C1 [do Carmo, J. M.; da Silva, A. A.; Sessums, P. O.; Ebaady, S. H.; Pace, B. R.; Rushing, J. S.; Davis, M. T.; Hall, J. E.] Univ Mississippi, Med Ctr, Dept Physiol & Biophys, Jackson, MS 39216 USA.
C3 University of Mississippi; University of Mississippi Medical Center
RP do Carmo, JM (corresponding author), Univ Mississippi, Med Ctr, Dept Physiol & Biophys, 2500 North State St, Jackson, MS 39216 USA.
EM jdocarmo@umc.edu
RI da Silva, Alexandre/A-6947-2009; Silva, Alexandre/K-8054-2014
OI da Silva, Alexandre/0000-0002-3233-7674; Hall, John/0000-0001-9867-5855;
   Silva, Alexandre/0000-0003-4504-0607
FU National Heart, Lung and Blood Institute [PO1HL-51971]; American Heart
   Association
FX This research was supported by the National Heart, Lung and Blood
   Institute Grant PO1HL-51971 and by a Scientist Development Grant from
   the American Heart Association to JM do Carmo.
CR Bjorbæk C, 2001, J BIOL CHEM, V276, P4747, DOI 10.1074/jbc.M007439200
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NR 20
TC 21
Z9 22
U1 0
U2 3
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0307-0565
EI 1476-5497
J9 INT J OBESITY
JI Int. J. Obes.
PD JUN
PY 2014
VL 38
IS 6
BP 775
EP 783
DI 10.1038/ijo.2013.177
PG 9
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA AJ2PJ
UT WOS:000337499900004
PM 24030516
OA Bronze, Green Accepted
DA 2025-06-11
ER

PT J
AU Bal, NB
   Güney, C
   Yildirim, OG
   Akar, F
   Demirel-Yilmaz, E
AF Bal, Nur Banu
   Guney, Ceren
   Yildirim, Onur Gokhan
   Akar, Fatma
   Demirel-Yilmaz, Emine
TI Myricetin May Improve Cardiac Dysfunction Possibly Through Regulating
   Blood Pressure and Cellular Stress Molecules in High-Fructose-Fed Rats
SO ANATOLIAN JOURNAL OF CARDIOLOGY
LA English
DT Article
DE Fructose; myricetin; cardiac dysfunction; blood pressure; cellular
   stress molecules
ID METABOLIC SYNDROME; MAPK; HYPERTENSION
AB Background: The aim of this study was to examine the effect of myricetin on cardiac dys- function caused by high fructose intake. Methods: Fructose was given to the rats as a 20% solution in drinking water for 15 weeks. Myricetin was administered by oral gavage for the last 6 weeks. Systolic blood pressure was measured by tail -cuff method. The effects of isoprenaline, phenylephrine, and ace- tylcholine on cardiac contractility and rhythmicity were recorded in the isolated right atrium and left ventricular papillary muscles. In addition to biochemical measurements, the cardiac expressions of cellular stress -related proteins were determined by western blotting. Results: Myricetin improved systolic blood pressure but did not affect body weight, plasma glucose, and triglyceride levels in fructose -fed rats. The impairment of isoprenaline- and phenylephrine-mediated increases in atrial contraction and sinus rate in fructose -fed rats was restored by myricetin treatment. Isoprenaline, phenylephrine, and acetylcho- line -mediated papillary muscle contractions were not changed by fructose or myricetin administration. The expression of the mitochondrial fission marker dynamin-related protein 1 and the mitophagic marker PTEN-induced kinase 1 (PINK1) was enhanced in the fructose -fed rat, and myricetin treatment markedly attenuated PINK1 expression. Highfructose intake augmented phosphorylation of the proinflammatory molecule Nuclear factor kappa B (NF-kappa B) and the stress -regulated kinase JNK1, but myricetin only reduced NF-kappa B expression. Moreover, myricetin diminished the elevation in the expression of the pro-apoptotic Bax. Conclusion: Our results imply that myricetin has a protective role in cardiac irregulari- ties induced by a high -fructose diet through reducing systolic blood pressure, improving cardiac adrenergic responses, suppressing PINK1, NF-kappa B, and Bax expression, and thus reflecting a potential therapeutic value.
C1 [Bal, Nur Banu; Akar, Fatma] Gazi Univ, Fac Pharm, Dept Pharmacol, Ankara, Turkiye.
   [Guney, Ceren] Duzce Univ, Fac Pharm, Dept Pharmacol, Duzce, Turkiye.
   [Yildirim, Onur Gokhan] Artvin Coruh Univ, Vocat Sch Hlth Serv, Dept Pharm Serv, Artvin, Turkiye.
   [Demirel-Yilmaz, Emine] Ankara Univ, Fac Med, Dept Med Pharmacol, Ankara, Turkiye.
C3 Gazi University; Duzce University; Artvin Coruh University; Ankara
   University
RP Bal, NB (corresponding author), Gazi Univ, Fac Pharm, Dept Pharmacol, Ankara, Turkiye.
EM nurbanubal@gazi.edu.tr
RI Bal, Nur Banu/AHE-2262-2022; Güney, Ceren/AAK-4075-2021; YILDIRIM, Onur
   Gokhan/AAA-9156-2022
OI GUNEY, Ceren/0000-0002-3267-2886
FU Gazi and Artvin Coruh University Research Fund [TDK-2022- 7661,
   2021.S37.02.01]
FX This study was partially supported by grants from the Gazi and Artvin
   Coruh University Research Fund (project no: TDK-2022-7661 and
   2021.S37.02.01) .
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NR 49
TC 0
Z9 0
U1 2
U2 6
PU KARE PUBL
PI ISTANBUL
PA Goztepe Mah. Fahrettin Kerim Gokay Caddesi. No: 200/A D:2 Cemenzar -
   Kadkoy, ISTANBUL, Turkiye
SN 2149-2263
EI 2149-2271
J9 ANATOL J CARDIOL
JI Anat. J. Cardiol.
PD JAN
PY 2024
VL 28
IS 1
BP 55
EP 64
DI 10.14744/AnatolJCardiol.2023.3866
PG 10
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA KK1V5
UT WOS:001179772100003
PM 38167793
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Muñoz, M
   López-Oliva, E
   Pinilla, E
   Rodríguez, C
   Martínez, MP
   Contreras, C
   Gómez, A
   Benedito, S
   Sáenz-Medina, J
   Rivera, L
   Prieto, D
AF Munoz, Mercedes
   Lopez-Oliva, Elvira
   Pinilla, Estefano
   Rodriguez, Claudia
   Martinez, Maria Pilar
   Contreras, Cristina
   Gomez, Alfonso
   Benedito, Sara
   Saenz-Medina, Javier
   Rivera, Luis
   Prieto, Dolores
TI Differential contribution of renal cytochrome P450 enzymes to kidney
   endothelial dysfunction and vascular oxidative stress in obesity
SO BIOCHEMICAL PHARMACOLOGY
LA English
DT Article
DE CYP2C epoxygenases; CYP4 hydroxylase; Endothelial dysfunction; Reactive
   oxygen species; Kidney preglomerular arteries; Obesity
ID SOLUBLE EPOXIDE HYDROLASE; URINARY 20-HYDROXYEICOSATETRAENOIC ACID;
   METABOLIC SYNDROME; HYPERPOLARIZING FACTOR; ELEVATED 20-HETE;
   HYPERTENSION; INJURY; ARTERIES; EICOSANOIDS; INFLAMMATION
AB Arachidonic acid (AA)-derived cytochrome P450 (CYP) derivatives, epoxyeicosatrienoic acids (EETs) and 20hidroxyeicosatetranoic acid (20-HETE), play a key role in kidney tubular and vascular functions and blood pressure. Altered metabolism of CYP epoxygenases and CYP hydroxylases has differentially been involved in the pathogenesis of metabolic disease-associated vascular complications, although the mechanisms responsible for the vascular injury are unclear. The present study aimed to assess whether obesity-induced changes in CYP enzymes may contribute to oxidative stress and endothelial dysfunction in kidney preglomerular arteries. Endothelial function and reactive oxygen species (ROS) production were assessed in interlobar arteries of obese Zucker rats (OZR) and their lean counterparts lean Zucker rats (LZR) and the effects of CYP2C and CYP4A inhibitors sulfaphenazole and HET0016, respectively, were examined on the endothelium-dependent relaxations and O2 center dot- and H2O2 levels of preglomerular arteries. Non-nitric oxide (NO) non-prostanoid endothelium-derived hyperpolarization (EDH)-type responses were preserved but resistant to the CYP epoxygenase blocker sulfaphenazole in OZR in contrast to those in LZR. Sulfaphenazole did not further inhibit reduced arterial H2O2 levels, and CYP2C11/CYP2C23 enzymes were downregulated in intrarenal arteries from OZR. Renal EDH-mediated relaxations were preserved in obese rats by the enhanced activity and expression of endothelial calciumactivated potassium channels (KCa). CYP4A blockade restored impaired NO-mediated dilatation and inhibited augmented O2 center dot- production in kidney arteries from OZR. The current data demonstrate that both decreased endothelial CYP2C11/ CYP2C23-derived vasodilator H2O2 and augmented CYP4A-derived 20-HETE contribute to endothelial dysfunction and vascular oxidative stress in obesity. CYP4A inhibitors ameliorate arterial oxidative stress and restore endothelial function which suggests its therapeutic potential for the vascular complications of obesity-associated kidney injury.
C1 [Munoz, Mercedes; Lopez-Oliva, Elvira; Pinilla, Estefano; Rodriguez, Claudia; Contreras, Cristina; Gomez, Alfonso; Benedito, Sara; Rivera, Luis; Prieto, Dolores] Univ Complutense, Fac Farm, Dept Fisiol, Madrid, Spain.
   [Martinez, Maria Pilar] Univ Complutense, Fac Vet, Dept Anat & Embriol, Madrid, Spain.
   [Saenz-Medina, Javier] Hosp Univ Puerta Hierro Majadahonda, Dept Urol, Madrid, Spain.
C3 Complutense University of Madrid; Complutense University of Madrid;
   Hospital Puerta de Hierro-Majadahonda
RP Rivera, L; Prieto, D (corresponding author), Univ Complutense Madrid, Fac Farm, Dept Fisiol, Madrid 28040, Spain.
EM dprieto@ucm.es
RI Pinilla, Estéfano/ABD-9938-2020; López-Oliva, Elvira/L-1660-2014;
   Contreras, Cristina/N-7257-2019; Saenz Medina, Javier/E-9391-2016;
   Rivera de los Arcos, Luis/T-2247-2018; Rodriguez Prados,
   Claudia/T-2239-2018; Martinez, Pilar/E-8591-2016
OI Saenz Medina, Javier/0000-0002-8568-854X; Pinilla,
   Estefano/0000-0002-7852-992X; Rivera de los Arcos,
   Luis/0000-0002-0187-707X; Rodriguez Prados, Claudia/0000-0002-1102-277X;
   Martinez, Pilar/0000-0001-9063-3191
FU Ministerio de Ciencia e Innovacion, Spain [PID2019-105689RB-I00]; FEDER
   Program of EU; Universidad Complutense de Madrid
FX This work was supported by PID2019-105689RB-I00 (Ministerio de Ciencia e
   Innovacion, Spain) cofounded by the FEDER Program of EU, and grant for
   UCM research group from Universidad Complutense de Madrid. Manuel
   Perales and Francisco Puente are thanked for expert technical
   assistance.
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NR 51
TC 4
Z9 5
U1 0
U2 13
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0006-2952
EI 1873-2968
J9 BIOCHEM PHARMACOL
JI Biochem. Pharmacol.
PD JAN
PY 2022
VL 195
AR 114850
DI 10.1016/j.bcp.2021.114850
EA DEC 2021
PG 11
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA XM7KQ
UT WOS:000729001500005
PM 34822809
OA Green Accepted, hybrid
DA 2025-06-11
ER

PT J
AU Esmaeilinezhad, Z
   Barati-Boldaji, R
   Brett, NR
   de Zepetnek, JOT
   Bellissimo, N
   Babajafari, S
   Sohrabi, Z
AF Esmaeilinezhad, Z.
   Barati-Boldaji, R.
   Brett, N. R.
   de Zepetnek, J. O. T.
   Bellissimo, N.
   Babajafari, S.
   Sohrabi, Z.
TI The effect of synbiotics pomegranate juice on cardiovascular risk
   factors in PCOS patients: a randomized, triple-blinded, controlled trial
SO JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
LA English
DT Article
DE Synbiotic; Oxidative stress; Dyslipidemia; Polycystic ovarian syndrome;
   Punicaceae
ID POLYCYSTIC-OVARY-SYNDROME; FATTY LIVER-DISEASE; OXIDATIVE STRESS;
   INSULIN-RESISTANCE; DIABETIC-PATIENTS; LIPID-PEROXIDATION; METABOLIC
   SYNDROME; HUMAN PLASMA; SUPPLEMENTATION; CONSUMPTION
AB Purpose Polycystic ovarian syndrome (PCOS) is one of the most common metabolic and endocrine disorders. Functional foods like pomegranate and probiotics are those that are considered to have beneficial effects on metabolic diseases beyond their basic nutritional value. So, we aimed to evaluate the effect of synbiotic pomegranate juice (SPJ) on cardiovascular risk factors on PCOS patients.
   Methods This was a randomized, triple-blinded, 8-week trial. Participants were randomly assigned to receive 300 mL/day of pomegranate juice (PJ), synbiotic beverage (SB), synbiotic pomegranate juice (SPJ), or placebo beverage (PB). Biochemical indices (lipid profile, Total Antioxidant Capacity (TAC), Malondialdehyde (MDA), high sensitive C-Reactive Protein (hs-CRP)) and blood pressure were assessed before and after the intervention.
   Results Participants in the PJ, SB, and SPJ groups experienced improvement in their lipid profile, oxidative stress, inflammation, and blood pressure during the time. Compared to placebo, Total Cholesterol (TC) was lower in the SB group (P < 0.01), LDL-c was lower in the SPJ and SB groups (P < 0.01), and HDL-c was higher in the SPJ and PJ groups (P < 0.01). With regards to oxidative stress and inflammation, when compared with placebo, MDA was lower in the SPJ, SB, and PJ groups (P < 0.001), TAC was increased in the SPJ and PJ groups (P < 0.001), and hs-CRP was decreased in the PJ group (P = 0.02). Blood pressure (BP) was lower in the SPJ and PJ groups compared to placebo (P < 0.001; P < 0.01, respectively).
   Conclusions Consuming daily SPJ for 8 weeks improved metabolic, oxidative, inflammatory, and BP outcomes in females with PCOS. This trial was registered in the Iranian Registry of Clinical Trials (IRCT20170207032439N2).
C1 [Esmaeilinezhad, Z.; Barati-Boldaji, R.; Babajafari, S.; Sohrabi, Z.] Shiraz Univ Med Sci, Sch Nutr & Food Sci, Nutr Res Ctr, Razi Blvd, Shiraz, Iran.
   [Brett, N. R.; Bellissimo, N.] Ryerson Univ, Sch Nutr, Toronto, ON, Canada.
   [de Zepetnek, J. O. T.] Univ Regina, Fac Kinesiol & Hlth Studies, Regina, SK, Canada.
C3 Shiraz University of Medical Science; Toronto Metropolitan University;
   University of Regina
RP Babajafari, S (corresponding author), Shiraz Univ Med Sci, Sch Nutr & Food Sci, Nutr Res Ctr, Razi Blvd, Shiraz, Iran.
EM jafaris@sums.ac.ir
RI Esfandabad, Siavash/A-6807-2019; Sohrabi, Zahra/R-4948-2017
OI Brett, Neil/0000-0002-6175-2535; Totosy de Zepetnek,
   Julia/0000-0001-7011-5143; Bellissimo, Nick/0000-0002-6177-3731;
   Sohrabi, Zahra/0000-0003-4572-3942; Barati-Boldaji,
   Reza/0000-0002-7251-9202
FU Shiraz University of Medical Sciences [No12983]
FX The present article was extracted from the thesis written by Zahra
   Esmaeilinezhad. This article was financially supported by Shiraz
   University of Medical Sciences grants No12983. The author declared that
   they have no other relevant financial interest.
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NR 64
TC 42
Z9 42
U1 0
U2 17
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0391-4097
EI 1720-8386
J9 J ENDOCRINOL INVEST
JI J. Endocrinol. Invest.
PD APR
PY 2020
VL 43
IS 4
BP 539
EP 548
DI 10.1007/s40618-019-01139-x
EA NOV 2019
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA KT9SO
UT WOS:000495720800001
PM 31713129
DA 2025-06-11
ER

PT J
AU Van Hecke, T
   Jakobsen, LMA
   Vossen, E
   Guéraud, F
   De Vos, F
   Pierre, F
   Bertram, HCS
   De Smet, S
AF Van Hecke, Thomas
   Jakobsen, Louise M. A.
   Vossen, Els
   Gueraud, Francoise
   De Vos, Filip
   Pierre, Fabrice
   Bertram, Hanne C. S.
   De Smet, Stefaan
TI Short-term beef consumption promotes systemic oxidative stress, TMAO
   formation and inflammation in rats, and dietary fat content modulates
   these effects
SO FOOD & FUNCTION
LA English
DT Article
ID PERFORMANCE LIQUID-CHROMATOGRAPHY; DNA ADDUCT FORMATION; C-REACTIVE
   PROTEIN; RED MEAT INTAKE; LIPID-PEROXIDATION; METABOLIC SYNDROME;
   L-CARNITINE; VITAMIN-E; CANCER; RISK
AB A high consumption of red and/or processed meat is associated with a higher risk to develop several chronic diseases in which oxidative stress, trimethylamine-N-oxide (TMAO) and/or inflammation are involved. We aimed to elucidate the effect of white (chicken) vs. red (beef) meat consumption in a low vs. high dietary fat context (2 x 2 factorial design) on oxidative stress, TMAO and inflammation in Sprague-Dawley rats. Higher malondialdehyde (MDA) concentrations were found in gastrointestinal contents (up to 96% higher) and colonic tissues (+8.8%) of rats fed the beef diets (all P < 0.05). The lean beef diet resulted in lower blood glutathione, higher urinary excretion of the major 4-hydroxy-nonenal metabolite, and higher plasma C-reactive protein, compared to the other dietary treatments (all P < 0.05). Rats on the fat beef diet had higher renal MDA (+24.4% compared to all other diets) and heart MDA (+12.9% compared to lean chicken) and lower liver vitamin E (-26.2% compared to lean chicken) (all P < 0.05). Rats on the fat diets had lower plasma vitamin E (-23.8%), lower brain MDA (-6.8%) and higher plasma superoxide dismutase activity (+38.6%), higher blood glutathione (+16.9%) (all P < 0.05) and tendency to higher ventral prostate MDA (+14.5%, P = 0.078) and prostate weight (+18.9%, P = 0.073), compared to rats on the lean diets. Consumption of the beef diets resulted in higher urinary trimethylamine (4.5-fold) and TMAO (3.7-fold) concentrations (P < 0.001), compared to the chicken diets. In conclusion, consumption of a high beef diet may stimulate gastrointestinal and/or systemic oxidative stress, TMAO formation and inflammation, depending on the dietary fat content and composition.
C1 [Van Hecke, Thomas; Vossen, Els; De Smet, Stefaan] Univ Ghent, Dept Anim Prod, Lab Anim Nutr & Anim Prod Qual, Melle, Belgium.
   [Jakobsen, Louise M. A.; Bertram, Hanne C. S.] Aarhus Univ, Dept Food Sci, Food Metabol & Sensory, Arslev, Denmark.
   [Gueraud, Francoise; Pierre, Fabrice] UPS, INRA, INP, UMR1331 Toxalim,Team 9 Prevent & Promot Carcinoge, Toulouse, France.
   [De Vos, Filip] Univ Ghent, Dept Pharmaceut Anal, Lab Radiopharm, Ghent, Belgium.
C3 Ghent University; Aarhus University; Universite de Toulouse; Universite
   Toulouse III - Paul Sabatier; Centre National de la Recherche
   Scientifique (CNRS); CNRS - Institute of Physics (INP); Universite
   Federale Toulouse Midi-Pyrenees (ComUE); Institut National Polytechnique
   de Toulouse; INRAE; Ghent University
RP De Smet, S (corresponding author), Univ Ghent, Dept Anim Prod, Lab Anim Nutr & Anim Prod Qual, Melle, Belgium.
EM stefaan.desmet@ugent.be
RI Jakobsen, Louise/AAD-3297-2021; Gueraud, Francoise/ITT-5567-2023;
   Bertram, Hanne/I-8439-2019; De Smet, Stefaan/N-7576-2017
OI De Smet, Stefaan/0000-0003-1422-805X; Jakobsen, Louise Margrethe
   Arildsen/0000-0002-2631-7386; Van Hecke, Thomas/0000-0002-6176-6523;
   Bertram, Hanne Christine/0000-0002-1882-5321; Gueraud,
   Francoise/0000-0001-5455-1244
FU Federal Public Service of Health, Food Chain Safety and Environment,
   Belgium [RF-11/625]
FX This study was financed by the Federal Public Service of Health, Food
   Chain Safety and Environment, Belgium (Grant RF-11/625 MEATNOX). The
   Federal Public Service of Health, Food Chain Safety and Environment had
   no role in the design, analysis or writing of this article.
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NR 61
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Z9 36
U1 2
U2 37
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PY 2016
VL 7
IS 9
BP 3760
EP 3771
DI 10.1039/c6fo00462h
PG 12
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA DX3DS
UT WOS:000384254100011
PM 27531020
DA 2025-06-11
ER

PT J
AU Szostak, J
   Laurant, P
AF Szostak, Justyna
   Laurant, Pascal
TI The forgotten face of regular physical exercise: a 'natural'
   anti-atherogenic activity
SO CLINICAL SCIENCE
LA English
DT Review
DE atherosclerosis; exercise; inflammation; myokine; obesity; reactive
   oxygen species (ROS); sedentary lifestyle
ID CORONARY-ARTERY-DISEASE; NECROSIS-FACTOR-ALPHA; ENDOTHELIUM-DEPENDENT
   VASODILATION; CARDIOVASCULAR RISK-FACTORS; LIFE-STYLE INTERVENTION;
   ALL-CAUSE MORTALITY; INDUCED WEIGHT-LOSS; INSULIN-RESISTANCE;
   NITRIC-OXIDE; OXIDATIVE STRESS
AB Humans are not programmed to be inactive. The combination of both accelerated sedentary lifestyle and constant food availability disturbs ancient metabolic processes leading to excessive storage of energy in tissue, dyslipidaemia and insulin resistance. As a consequence, the prevalence of Type 2 diabetes, obesity and the metabolic syndrome has increased significantly over the last 30 years. A low level of physical activity and decreased daily energy expenditure contribute to the increased risk of cardiovascular morbidity and mortality following atherosclerotic vascular damage. Physical inactivity leads to the accumulation of visceral fat and consequently the activation of the oxidative stress/inflammation cascade, which promotes the development of atherosclerosis. Considering physical activity as a 'natural' programmed state, it is assumed that it possesses atheroprotective properties. Exercise prevents plaque development and induces the regression of coronary stenosis. Furthermore, experimental studies have revealed that exercise prevents the conversion of plaques into a vulnerable phenotype, thus preventing the appearance of fatal lesions. Exercise promotes atheroprotection possibly by reducing or preventing oxidative stress and inflammation through at least two distinct pathways. Exercise, through laminar shear stress activation, down-regulates endothelial AT(I)R (angiotensin II type I receptor) expression, leading to decreases in NADPH oxidase activity and superoxide anion production, which in turn decreases ROS (reactive oxygen species) generation, and preserves endothelial NO bioavailability and its protective anti-atherogenic effects. Contracting skeletal muscle now emerges as a new organ that releases anti-inflammatory cytokines, such as IL-6 (interleukin-6). IL-6 inhibits TNF-alpha (tumour necrosis factor-alpha) production in adipose tissue and macrophages. The down-regulation of TNF-alpha induced by skeletal-muscle-derived IL-6 may also participate in mediating the atheroprotective effect of physical activity.
C1 [Laurant, Pascal] Pole Sportif & Rech Univ, Lab Pharma Ecol Cardiovasc, EA4278, F-84000 Avignon, France.
   [Szostak, Justyna] CHU Vaudois, Serv Med Vasc, Dept Med Interne, CH-1011 Lausanne, Switzerland.
C3 University of Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV)
RP Laurant, P (corresponding author), Pole Sportif & Rech Univ, Lab Pharma Ecol Cardiovasc, EA4278, 15 Blvd Limbert, F-84000 Avignon, France.
EM pascal.laurant@univ-avignon.fr
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NR 152
TC 116
Z9 131
U1 0
U2 18
PU PORTLAND PRESS LTD
PI LONDON
PA 1ST FLR, 10 QUEEN STREET PLACE, LONDON, ENGLAND
SN 0143-5221
EI 1470-8736
J9 CLIN SCI
JI Clin. Sci.
PD AUG
PY 2011
VL 121
IS 3-4
BP 91
EP 106
DI 10.1042/CS20100520
PG 16
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 807ZL
UT WOS:000293941500001
PM 21729002
DA 2025-06-11
ER

PT J
AU Wilund, KR
   Tomayko, EJ
   Wu, PT
   Chung, HR
   Vallurupalli, S
   Lakshminarayanan, B
   Fernhall, B
AF Wilund, Kenneth R.
   Tomayko, Emily J.
   Wu, Pei-Tzu
   Chung, Hae Ryong
   Vallurupalli, Srikanth
   Lakshminarayanan, Batlagundu
   Fernhall, Bo
TI Intradialytic exercise training reduces oxidative stress and epicardial
   fat: a pilot study
SO NEPHROLOGY DIALYSIS TRANSPLANTATION
LA English
DT Article
DE cardiovascular disease; exercise; haemodialysis; inflammation; oxidative
   stress
ID STAGE RENAL-DISEASE; ADIPOSE-TISSUE; HEMODIALYSIS-PATIENTS; INFLAMMATORY
   MARKERS; METABOLIC SYNDROME; PHYSICAL-ACTIVITY; KIDNEY-DISEASE;
   FETUIN-A; MALNUTRITION; ECHOCARDIOGRAPHY
AB Background. Cardiovascular disease (CVD) mortality rates are greatly elevated in chronic kidney disease patients receiving maintenance haemodialysis therapy. The purpose of this study was to evaluate the efficacy of intradialytic endurance exercise training on novel risk factors that may contribute to this excessive CVD risk.
   Methods. Seventeen haemodialysis patients were randomized to either an intradialytic exercise training (cycling) group (EX; n = 8) or a non-exercising control group (CON; n = 9) for 4 months. At baseline and following the intervention, we measured serum parameters related to CVD risk and renal function, used echocardiography to measure variables related to cardiac structure and function and assessed physical performance by a validated shuttle walk test.
   Results. Performance on the shuttle walk test increased by 17% in EX (P < 0.05), but did not change in CON. There was no change in serum lipids or inflammatory markers (C-reactive protein, interleukin-6) in either group. Serum thiobarbituric acid reactive substances, a marker of oxidative stress, were reduced by 38% in EX (P < 0.05), but did not change in CON. In addition, serum alkaline phosphatase (ALP), a putative risk factor for vascular calcification, was reduced by 27% in EX (P < 0.05), but did not change in CON. There was no change in left atrial volume, left ventricular mass or myocardial performance index in either group. However, the thickness of the epicardial fat layer was reduced by 11% in EX (P < 0.05), but did not change in CON. Furthermore, the change in physical performance was inversely correlated to the change in epicardial fat (r = -0.63; P = 0.03).
   Conclusions. These results suggest that endurance exercise training may improve CVD risk in haemodialysis patients by decreasing novel risk factors including serum oxidative stress, ALP and epicardial fat.
C1 [Wilund, Kenneth R.; Wu, Pei-Tzu; Chung, Hae Ryong; Fernhall, Bo] Univ Illinois, Dept Kinesiol & Community Hlth, Urbana, IL 61801 USA.
   [Wilund, Kenneth R.; Tomayko, Emily J.] Univ Illinois, Div Nutr Sci, Urbana, IL 61801 USA.
   [Lakshminarayanan, Batlagundu] Univ Illinois, Dept Internal Med, Urbana, IL 61801 USA.
   [Vallurupalli, Srikanth] So Illinois Univ, Dept Med, Sch Med, Springfield, IL USA.
C3 University of Illinois System; University of Illinois Urbana-Champaign;
   University of Illinois System; University of Illinois Urbana-Champaign;
   University of Illinois System; University of Illinois Urbana-Champaign;
   Southern Illinois University System; Southern Illinois University
RP Wilund, KR (corresponding author), Univ Illinois, Dept Kinesiol & Community Hlth, Urbana, IL 61801 USA.
EM kwilund@illinois.edu
RI Wu, Eliza/HLH-7690-2023; Vallurupalli, Srikanth/H-9413-2019
OI Vallurupalli, Srikanth/0000-0002-2404-1152
FU College of Medicine, University of Illinois at Urbana-Champaign
FX We would like to thank Marina Zhivov and the staff at the
   Echocardiography Laboratory at Provena Medical Center for their help in
   conducting and analysing the echocardiograms and Dr James Kumar for his
   assistance with the exercise testing. This work was supported by a grant
   from the College of Medicine, University of Illinois at
   Urbana-Champaign.
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NR 42
TC 121
Z9 129
U1 0
U2 11
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0931-0509
J9 NEPHROL DIAL TRANSPL
JI Nephrol. Dial. Transplant.
PD AUG
PY 2010
VL 25
IS 8
BP 2695
EP 2701
DI 10.1093/ndt/gfq106
PG 7
WC Transplantation; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Transplantation; Urology & Nephrology
GA 645RV
UT WOS:000281483300049
PM 20190243
DA 2025-06-11
ER

PT J
AU Botero, D
   Ebbeling, CB
   Blumberg, JB
   Ribaya-Mercado, JD
   Creager, MA
   Swain, JF
   Feldman, HA
   Ludwig, DS
AF Botero, Diego
   Ebbeling, Cara B.
   Blumberg, Jeffrey B.
   Ribaya-Mercado, Judy D.
   Creager, Mark A.
   Swain, Janis F.
   Feldman, Henry A.
   Ludwig, David S.
TI Acute Effects of Dietary Glycemic Index on Antioxidant Capacity in a
   Nutrient-controlled Feeding Study
SO OBESITY
LA English
DT Article
ID MIDDLE-AGED WOMEN; OXIDATIVE STRESS; INSULIN-RESISTANCE;
   CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; CONTROLLED-TRIAL;
   BLOOD-PRESSURE; FIBER INTAKE; WEIGHT-LOSS; DASH DIET
AB Oxidative stress, caused by an imbalance between antioxidant capacity and reactive oxygen species, may be an early event in a metabolic cascade elicited by a high glycemic index (GI) diet, ultimately increasing the risk for cardiovascular disease and diabetes. We conducted a feeding study to evaluate the acute effects of low-GI compared with high-GI diets on oxidative stress and cardiovascular disease risk factors. The crossover study comprised two 10-day in-patient admissions to a clinical research center. For the admissions, 12 overweight or obese (BMI: 27-45kg/m(2)) male subjects aged 18-35 years consumed low-GI or high-GI diets controlled for potentially confounding nutrients. On day 7, after an overnight fast and then during a 5-h postprandial period, we assessed total antioxidant capacity (total and perchloric acid (PCA) protein-precipitated plasma oxygen radical absorbance capacity (ORAC) assay) and oxidative stress status (urinary F-2 alpha-isoprostanes (F2IP)). On day 10, we measured cardiovascular disease risk factors. Under fasting conditions, total antioxidant capacity was significantly higher during the low-GI vs. high-GI diet based on total ORAC (11,736 +/- 668 vs. 10,381 +/- 612 mu mol Trolox equivalents/l, P = 0.002) and PCA-ORAC (1,276 +/- 96 vs. 1,210 +/- 96 mu mol Trolox equivalents/l, P = 0.02). Area under the postprandial response curve also differed significantly between the two diets for total ORAC and PCA-ORAC. No diet effects were observed for the other variables. Enhancement in plasma total antioxidant capacity occurs within 1 week on a low-GI diet, before changes in other risk factors, raising the possibility that this phenomenon may mediate, at least in part, the previously reported effects of GI on health.
C1 [Botero, Diego; Ebbeling, Cara B.; Feldman, Henry A.; Ludwig, David S.] Childrens Hosp, Dept Med, Boston, MA 02115 USA.
   [Blumberg, Jeffrey B.; Ribaya-Mercado, Judy D.] Tufts Univ, Human Nutr Res Ctr Aging, Jean Mayer USDA, Boston, MA 02111 USA.
   [Creager, Mark A.; Swain, Janis F.] Brigham & Womens Hosp, Dept Med, Boston, MA 02115 USA.
C3 Harvard University; Harvard University Medical Affiliates; Boston
   Children's Hospital; United States Department of Agriculture (USDA);
   Tufts University; Harvard University; Harvard University Medical
   Affiliates; Brigham & Women's Hospital
RP Ludwig, DS (corresponding author), Childrens Hosp, Dept Med, Boston, MA 02115 USA.
EM david.ludwig@childrens.harvard.edu
RI Feldman, Henry/M-2302-2013; Blumberg, Jeffrey/ABH-7888-2020
OI Ludwig, David/0000-0003-3307-8544
FU National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
   [R01 DK59240]; Charles H. Hood Foundation; New Balance Foundation [M01
   RR02635]; National Institutes of Health
FX The project described was supported by grant R01 DK59240 from the
   National Institute of Diabetes and Digestive and Kidney Diseases
   (NIDDK), the Charles H. Hood Foundation, the New Balance Foundation, and
   grant M01 RR02635 from the National Institutes of Health to the General
   Clinical Research Center at the Brigham and Women's Hospital, Boston,
   MA. The content is solely the responsibility of the authors and does not
   necessarily represent the official views of the National Institutes of
   Health. We thank the staff of the General Clinical Research Center at
   Brigham and Women's Hospital for assistance in assessing outcomes and
   implementing the dietary interventions, Dorota Pawlak and Ashley
   McCarron for assistance with designing the diets, Matthew Grunert and
   Jesslyn Furst for assistance with assessing endothelial function, Lenard
   Lesser for assistance with preliminary work to evaluate the GI of mixed
   meals, Michael Leidig for assistance with study logistics, Linda
   Seger-Shippee for assistance with recruitment, and Hope Forbes and
   Meredith Beard for assistance with data management.
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NR 41
TC 44
Z9 52
U1 0
U2 8
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1930-7381
EI 1930-739X
J9 OBESITY
JI Obesity
PD SEP
PY 2009
VL 17
IS 9
BP 1664
EP 1670
DI 10.1038/oby.2009.203
PG 7
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 490TG
UT WOS:000269527200004
PM 19543205
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Zhang, Y
   Mao, XD
   Cao, AL
   Chu, S
   Li, ZJ
   Wang, YM
   Peng, W
   Wang, L
   Wang, H
AF Zhang, Yang
   Mao, Xiao-Dong
   Cao, Ai-Li
   Chu, Shuang
   Li, Zhi-Jun
   Wang, Yun-Man
   Peng, Wen
   Wang, Li
   Wang, Hao
TI Astragaloside IV prevents endothelial dysfunction by improving oxidative
   stress in streptozotocin-induced diabetic mouse aortas
SO EXPERIMENTAL AND THERAPEUTIC MEDICINE
LA English
DT Article
DE diabetic vascular complications; endothelial dysfunction; oxidative
   stress; nitric oxide; astragaloside IV
ID NITRIC-OXIDE; NADPH OXIDASE; ANGIOTENSIN-II; RISK-FACTORS;
   CARDIOVASCULAR-DISEASE; INSULIN-RESISTANCE; METABOLIC SYNDROME; REACTIVE
   OXYGEN; IN-VIVO; HYPERTENSION
AB Oxidative stress serves a role in endothelial dysfunction exhibited by patients with diabetes mellitus. Astragaloside IV (AS-IV) is a major active ingredient of Radix Astragali, which is considered to exhibit vasoprotective effects through unknown mechanisms. Thus, the current study was performed to investigate the protective effects of AS-IV in streptozotocin (STZ)-induced endothelial dysfunction and to explore whether antioxidant mechanisms were involved. The protective effects of AS-IV on the endothelium-dependent relaxation and contraction of aortic rings were determined by isometric tension recordings. NADPH subunits and endothelial nitric oxide synthase (eNOS) expression was identified via western blotting. Superoxide dismutase and malondialdehyde levels were assayed using ELISA. Furthermore, the generation of reactive oxygen species (ROS) and nitric oxide (NO) was detected via dihydroethidium and 4,5-diaminofluorescein diacetate staining, respectively. The results revealed that STZ-injected mice exhibited increased aortic endothelium-dependent vasoconstriction and decreased vasorelaxation to acetylcholine. However, AS-IV treatment reversed these effects. N-G-nitro-L-arginine was subsequently used to completely inhibit impaired relaxation. Accordingly, impaired NO generation was restored following AS-IV treatment by increasing eNOS phosphorylation levels. Furthermore, ROS formation was also depressed following AS-IV treatment compared with that in STZ-injected mice. AS-IV also decreased the expression of various NADPH subunits, including human neutrophil cytochrome b light chain, neutrophil cytosolic factor 1, NADPH oxidase (NOX)2, NOX4 and Rac-1. The results of the current study may provide novel evidence that diabetes-induced vascular injury arises from either the inhibition of eNOS or the activation of NOX-derived ROS generation. In addition, the results warrant further investigation into the application of AS-IV treatment, leading to the improvement of oxidative stress, in patients with diabetes exhibiting endothelial dysfunction.
C1 [Zhang, Yang; Li, Zhi-Jun; Wang, Yun-Man; Peng, Wen; Wang, Hao] Shanghai Univ Tradit Chinese Med, Putuo Hosp, Dept Nephrol, 164 Lanxi Rd, Shanghai 200062, Peoples R China.
   [Mao, Xiao-Dong; Cao, Ai-Li; Chu, Shuang; Wang, Li] Shanghai Univ Tradit Chinese Med, Putuo Hosp, Lab Renal Dis, 164 Lanxi Rd, Shanghai 200062, Peoples R China.
C3 Shanghai University of Traditional Chinese Medicine; Shanghai University
   of Traditional Chinese Medicine
RP Wang, H (corresponding author), Shanghai Univ Tradit Chinese Med, Putuo Hosp, Dept Nephrol, 164 Lanxi Rd, Shanghai 200062, Peoples R China.; Wang, L (corresponding author), Shanghai Univ Tradit Chinese Med, Putuo Hosp, Lab Renal Dis, 164 Lanxi Rd, Shanghai 200062, Peoples R China.
EM wanglitcm2007@163.com; wang402hao@163.com
RI Li, Zhijun/AFK-7926-2022
OI Cao, Aili/0000-0002-2059-1739
FU Innovation Program of Talent Project of Putuo District [2020360A];
   National Natural Science Foundation of China [81403235]; Key Medical
   Discipline Project of Shanghai Municipal Health Bureau [ZK2019A12];
   Independent Innovation Research Fund of Putuo District Science and
   Technology Committee [2012PTKW006]
FX The current study was supported by the Innovation Program of Talent
   Project of Putuo District (grant no. 2020360A), the National Natural
   Science Foundation of China (grant no. 81403235), the Key Medical
   Discipline Project of Shanghai Municipal Health Bureau (grant no.
   ZK2019A12) and the Independent Innovation Research Fund of Putuo
   District Science and Technology Committee (grant no. 2012PTKW006).
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NR 53
TC 13
Z9 15
U1 1
U2 14
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1792-0981
EI 1792-1015
J9 EXP THER MED
JI Exp. Ther. Med.
PD NOV
PY 2021
VL 22
IS 5
AR 1197
DI 10.3892/etm.2021.10631
PG 10
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA UM9HK
UT WOS:000693635000001
PM 34584542
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Michell, RH
AF Michell, Robert H.
TI Do inositol supplements enhance phosphatidylinositol supply and thus
   support endoplasmic reticulum function?
SO BRITISH JOURNAL OF NUTRITION
LA English
DT Article
DE Insulin resistance; Gestational diabetes mellitus; Polycystic ovarian
   syndrome; Spermatogenesis; Hypothyroidism; Non-alcoholic fatty liver
   disease; Endoplasmic reticulum stress
ID D-CHIRO-INOSITOL; UNFOLDED PROTEIN RESPONSE; GESTATIONAL
   DIABETES-MELLITUS; NEURAL-TUBE DEFECTS; FATTY LIVER-DISEASE;
   GLYCOSYLPHOSPHATIDYLINOSITOL-ANCHORED PROTEINS; INTERNATIONAL CONSENSUS
   CONFERENCE; POLYCYSTIC OVARIAN SYNDROME; RS641738 INCREASES RISK;
   MYOINOSITOL SUPPLEMENTATION
AB This review attempts to explain why consuming extra myoinositol (Ins), an essential component of membrane phospholipids, is often beneficial for patients with conditions characterised by insulin resistance, non-alcoholic fatty liver disease and endoplasmic reticulum (ER) stress. For decades we assumed that most human diets provide an adequate Ins supply, but newer evidence suggests that increasing Ins intake ameliorates several disorders, including polycystic ovary syndrome, gestational diabetes, metabolic syndrome, poor sperm development and retinopathy of prematurity. Proposed explanations often suggest functional enhancement of minor facets of Ins Biology such as insulin signalling through putative inositol-containing 'mediators', but offer no explanation for this selectivity. It is more likely that eating extra Ins corrects a deficiency of an abundant Ins-containing cell constituent, probably phosphatidylinositol (PtdIns). Much of a cell's PtdIns is in ER membranes, and an increase in ER membrane synthesis, enhancing the ER's functional capacity, is often an important part of cell responses to ER stress. This review: (a) reinterprets historical information on Ins deficiency as describing a set of events involving a failure of cells adequately to adapt to ER stress; (b) proposes that in the conditions that respond to dietary Ins there is an overstretching of Ins reserves that limits the stressed ER's ability to make the 'extra' PtdIns needed for ER membrane expansion; and (c) suggests that eating Ins supplements increases the Ins supply to Ins-deficient and ER-stressed cells, allowing them to make more PtdIns and to expand the ER membrane system and sustain ER functions.
C1 [Michell, Robert H.] Univ Birmingham, Sch Biosci, Birmingham B15 2TT, W Midlands, England.
C3 University of Birmingham
RP Michell, RH (corresponding author), Univ Birmingham, Sch Biosci, Birmingham B15 2TT, W Midlands, England.
EM r.h.michell@bham.ac.uk
RI Michell, Robert/AAT-4974-2020
OI Michell, Robert H/0000-0001-9422-9858
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NR 200
TC 25
Z9 26
U1 1
U2 26
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1145
EI 1475-2662
J9 BRIT J NUTR
JI Br. J. Nutr.
PD AUG 14
PY 2018
VL 120
IS 3
BP 301
EP 316
DI 10.1017/S0007114518000946
PG 16
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA GO6QE
UT WOS:000440173200007
PM 29859544
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Li, H
   Liu, X
   Ren, ZQ
   Gu, JX
   Lu, YJ
   Wang, XY
   Zhang, L
AF Li, He
   Liu, Xian
   Ren, Zhongqiao
   Gu, Jinxia
   Lu, Yingjie
   Wang, Xiaoyun
   Zhang, Lan
TI Effects of Diabetic Hyperglycemia on Central Ang-(1-7)-Mas-R-nNOS
   Pathways in Spontaneously Hypertensive Rats
SO CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
LA English
DT Article
DE Diabetic; Hypertension; Angiotensin-(1-7); Oxidative stress; Brain
   natriuretic peptide
ID ANGIOTENSIN-(1-7) INCREASES; NEUROGENIC HYPERTENSION; METABOLIC
   SYNDROME; OXIDATIVE STRESS; ISCHEMIC-STROKE; BLOOD-PRESSURE;
   NITRIC-OXIDE; RECEPTOR MAS; BRAIN; STREPTOZOTOCIN
AB Background/Aims: Hypertension is a major cause of stroke, and diabetes can increase incidence of this disease. We determined the role played by central angiotensin-(1-7) [Ang(1-7)] pathway in modulating spontaneously hypertension with diabetic hyperglycemia. Methods: Western Blot analysis and ELISA were used to determine the protein expression of Ang-(1-7) and its signal pathway Mas-R-nNOS in the cerebral cortex and hippocampus of spontaneously hypertensive rats (SHR) and control animals. In a subset of animals, diabetic hyperglycemia was induced by systemic injection of streptozotocin (STZ). We analyzed a relationship between the levels of central Ang-(1-7) and plasma brain natriuretic peptide (BNP) indicating a risk of ischemic stroke. We further examined the effects of Ang-(1-7) on arterial blood pressure. Results: Our findings demonstrated for the first time that administration of STZ 1) attenuates the levels of Ang-(1-7) in the cerebral cortex and hippocampus, which are closely linked to plasma BNP; and 2) leads to downregulation of central Ang-(1-7)-Mas-RnNOS pathways. Notably, STZ has greater effects in SHR. Additionally, inhibition of oxidative stress can largely improve downregulation of Ang-(1-7) in diabetic SHR. Moreover, central stimulation of Ang-(1-7) pathway or a blockade of oxidative stress improves systolic blood pressure in diabetic SHR. Conclusions: The Ang-(1-7) signaling pathway is engaged in the adaptive mechanisms associated with diabetic hypertension, suggesting that enhancing Ang-(1-7)-Mas-R-nNOS system is likely to be beneficial in preventing against cardiovascular and cerebrovascular dysfunction and vulnerability related to spontaneously hypertension, particularly to diabetic hypertension. (C) 2016 The Author(s) Published by S. Karger AG, Basel
C1 [Li, He; Liu, Xian; Ren, Zhongqiao; Gu, Jinxia; Lu, Yingjie; Wang, Xiaoyun; Zhang, Lan] Harbin Med Univ, Clin Hosp 4, Dept Cardiol, 37 Yiyuan St, Harbin 150001, Heilongjiang Pr, Peoples R China.
C3 Harbin Medical University
RP Zhang, L (corresponding author), Harbin Med Univ, Clin Hosp 4, Dept Cardiol, 37 Yiyuan St, Harbin 150001, Heilongjiang Pr, Peoples R China.
EM zhanglan6463@aol.com
FU Natural Science Foundation of Heilongjiang Province [QC2015106];
   National Health and Family Planning Commission [2014-388]
FX This work was supported in part by Natural Science Foundation of
   Heilongjiang Province (Grant# QC2015106, Lan Zhang) and National Health
   and Family Planning Commission (Grant# 2014-388, Xian Liu).
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NR 37
TC 12
Z9 13
U1 0
U2 1
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1015-8987
EI 1421-9778
J9 CELL PHYSIOL BIOCHEM
JI Cell. Physiol. Biochem.
PY 2016
VL 40
IS 5
BP 1186
EP 1197
DI 10.1159/000453172
PG 12
WC Cell Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Physiology
GA EH0CV
UT WOS:000391431000031
PM 27960152
OA gold
DA 2025-06-11
ER

PT J
AU Yamaoka, S
   Sasaki, K
   Sato, S
AF Yamaoka, Shin
   Sasaki, Kotomi
   Sato, Shin
TI Curcumin intake during lactation suppresses oxidative stress through
   upregulation of nuclear factor erythroid 2-related factor 2 in the
   kidneys of fructose-loaded female rat offspring exposed to maternal
   protein restriction
SO BIRTH DEFECTS RESEARCH
LA English
DT Article
DE curcumin; fructose; kidney; maternal undernutrition; NF-E2-related
   factor 2
ID METABOLIC SYNDROME; POLYPHENOL; EXPRESSION; INJURY
AB Background: A high-fructose diet causes the progression of chronic kidney disease. Maternal malnutrition during pregnancy and lactation increases oxidative stress, leading to chronic renal diseases later in life. We investigated whether curcumin intake during lactation could suppress oxidative stress and regulate NF-E2-related factor 2 (Nrf2) expression in the kidneys of fructose loaded female rat offspring exposed to maternal protein restriction.
   Methods: Pregnant Wistar rats received diets containing 20% (NP) or 8% (LP) casein and 0 or 2.5 g highly absorptive curcumin /kg diet containing-LP diets (LP/LP or LP/Cur) during lactation. At weaning, female offspring received either distilled water (W) or 10% fructose solution (Fr) and were divided into four groups: NP/NP/W, LP/LP/W, LP/LP/Fr, and LP/Cur/Fr. At week 13, glucose (Glc), triacylglycerol (Tg), and malondialdehyde (MDA) levels in the plasma, macrophages number, fibrotic area, glutathione (GSH) levels, glutathione peroxidase (GPx) activity, protein expression levels of Nrf2, heme oxygenase-1 (HO-1), and superoxide dismutase 1 (SOD1) in the kidneys were examined.
   Results: The plasma levels of Glc, TG, and MDA, the number of macrophages, and the percentage of fibrotic area in the kidneys of the LP/Cur/Fr group were significantly lower than those of the LP/LP/Fr group. The expression of Nrf2 and its downstream molecules HO-1 and SOD1, GSH levels, and GPx activity in the kidneys of the LP/Cur/Fr group were significantly higher than those of the LP/LP/Fr group.
   Conclusions: Maternal curcumin intake during lactation may suppress oxidative stress by upregulating Nrf2 expression in the kidneys of fructose-loaded female offspring exposed to maternal protein restriction.
C1 [Yamaoka, Shin; Sato, Shin] Aomori Univ Hlth & Welf, Grad Sch Hlth Sci, Aomori, Japan.
   [Yamaoka, Shin] Akita Nutr Jr Coll, Dept Nutr, 46-1 Shimokitate Sakuramamorisawa, Akita, Akita 0108515, Japan.
   [Sasaki, Kotomi; Sato, Shin] Aomori Univ Hlth & Welf, Dept Nutr, Aomori, Japan.
C3 Aomori University of Health & Welfare; Aomori University of Health &
   Welfare
RP Yamaoka, S (corresponding author), Akita Nutr Jr Coll, Dept Nutr, 46-1 Shimokitate Sakuramamorisawa, Akita, Akita 0108515, Japan.
EM 1993002@ms.auhw.ac.jp
RI Yamaoka, Shin/MBU-9366-2025
OI Yamaoka, Shin/0000-0001-9947-3219
FU Aomori University of Health and Welfare; Grants-in-Aid for Scientific
   Research [20K11649] Funding Source: KAKEN
FX Aomori University of Health and Welfare
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NR 47
TC 0
Z9 0
U1 0
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2472-1727
J9 BIRTH DEFECTS RES
JI Birth Defects Res.
PD APR 15
PY 2023
VL 115
IS 7
BP 674
EP 686
DI 10.1002/bdr2.2158
EA FEB 2023
PG 13
WC Developmental Biology; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Developmental Biology; Toxicology
GA A9LB8
UT WOS:000936965300001
PM 36811147
DA 2025-06-11
ER

PT J
AU Roque, CR
   Sampaio, LR
   Ito, MN
   Pinto, DV
   Caminha, JSR
   Nunes, PIG
   Raposo, RS
   Santos, FA
   Windmöller, CC
   Crespo-Lopez, ME
   Alvarez-Leite, JI
   Oriá, RB
   Pinheiro, RF
AF Roque, Cassia R.
   Sampaio, Leticia R.
   Ito, Mayumi N.
   Pinto, Daniel, V
   Caminha, Juan S. R.
   Nunes, Paulo I. G.
   Raposo, Ramon S.
   Santos, Flavia A.
   Windmoeller, Claudia C.
   Crespo-Lopez, Maria Elena
   Alvarez-Leite, Jacqueline, I
   Oria, Reinaldo B.
   Pinheiro, Ronald F.
TI Methylmercury chronic exposure affects the expression of DNA
   single-strand break repair genes, induces oxidative stress, and
   chromosomal abnormalities in young dyslipidemic APOE knockout
   mice
SO TOXICOLOGY
LA English
DT Article
DE Methylmercury; Dyslipidemia; ApoE knockout mice; Oxidative stress; DNA
   repair
ID METABOLIC SYNDROME; APOLIPOPROTEIN-E; BLOOD MERCURY; GENOTOXICITY;
   TRANSLOCATIONS; ASSOCIATION; DEFICIENCY; MECHANISMS; TOXICITY; DISEASE
AB Mercury (Hg) is one of the most toxic environmental pollutants, especially when methylated, forming methyl-mercury (MeHg). MeHg affects DNA repair, increases oxidative stress, and predisposes to cancer. MeHg neurotoxicity is well-known, but recently MeHg-associated cardiovascular effects were recognized. This study evaluated circulating lipids, oxidative stress, and genotoxicity after MeHg-chronic exposure (20 mg/L in drinking water) in C57BL/6J wild-type and APOE knockout (ko) mice, the latter, being spontaneously dyslipidemic. Experimental mice were assigned to four groups: non-intoxicated and MeHg-intoxicated wild-type mice and non-intoxicated and MeHg-intoxicated APOE ko mice. Plasma levels of triglycerides, total cholesterol (TC), HDL, and LDL were analyzed. Liver lipid peroxidation and splenic gene expression of xeroderma pigmentosum complementation groups A, C, D, and G (XPA, XPC, XPD, and XPG), X-ray repair cross-complementing protein 1 (XRCC1), and telomerase reverse transcriptase (TERT) were measured. Fur Hg levels confirmed chronic MeHg intoxication. MeHg exposure raises TC levels both in wild-type and APOE ko mice. HDL and LDL-cholesterol levels were increased only in the MeHg-challenged APOE ko mice. MeHg increased liver lipid peroxidation, regardless of the genetic background. Unintoxicated APOE ko mice showed higher expression of TERT than all other groups. APOE deficiency increases XPA expression, regardless of MeHg intoxication. Furthermore, MeHg-intoxicated mice had more cytogenetic abnormalities, effect which was independent of APOE deficiency. More studies are needed to dissect the interactions between circulating lipids, MeHg intoxication, and DNA-repair pathways even at young age, interactions that likely play critical roles in cell senescence and the risk for chronic disorders later in life.
C1 [Sampaio, Leticia R.; Ito, Mayumi N.; Pinheiro, Ronald F.] Univ Fed Ceara, Canc Cytogen Lab, Drug Res & Dev Ctr, Fortaleza, Ceara, Brazil.
   [Roque, Cassia R.; Pinto, Daniel, V; Caminha, Juan S. R.; Oria, Reinaldo B.] Univ Fed Ceara, Fac Med, Dept Morphol, Lab Tissue Healing Ontogeny & Nutr, Fortaleza, Ceara, Brazil.
   [Roque, Cassia R.; Pinto, Daniel, V; Caminha, Juan S. R.; Oria, Reinaldo B.] Univ Fed Ceara, Fac Med, Inst Biomed, Fortaleza, Ceara, Brazil.
   [Nunes, Paulo I. G.; Santos, Flavia A.] Univ Fed Ceara, Biomed Ctr, Nat Prod Lab, Fortaleza, Ceara, Brazil.
   [Raposo, Ramon S.] Univ Fortaleza, Hlth Sci, Expt Biol Core, Fortaleza, Ceara, Brazil.
   [Windmoeller, Claudia C.; Alvarez-Leite, Jacqueline, I] Univ Fed Minas Gerais, Dept Biochem & Immunol, Lab Atherosclerosis & Nutr Biochem, ICB, Belo Horizonte, MG, Brazil.
   [Crespo-Lopez, Maria Elena] Fed Univ Para, Inst Biol Sci, Lab Mol Pharmacol, Belem, Para, Brazil.
C3 Universidade Federal do Ceara; Universidade Federal do Ceara;
   Universidade Federal do Ceara; Universidade Federal do Ceara;
   Universidade Fortaleza; Universidade Federal de Minas Gerais;
   Universidade Federal do Para
RP Oriá, RB (corresponding author), Univ Fed Ceara, Lab Biol Tissue Healing Ontogeny & Nutr, Dept Morphol, Sch Med, Rua Coronel Nunes Melo 1315, BR-60430270 Fortaleza, Ceara, Brazil.; Oriá, RB (corresponding author), Univ Fed Ceara, Inst Biomed, Sch Med, Rua Coronel Nunes Melo 1315, BR-60430270 Fortaleza, Ceara, Brazil.
EM oria@ufc.br
RI ALVAREZ-LEITE, JACQUELINE/C-9175-2014; Oria, Reinaldo/D-6440-2014;
   Crespo-Lopez, Maria/X-7912-2018; Windmoller, Claudia/H-3647-2012;
   Santos, Flávia/IXN-5060-2023; Gomes Nunes, Paulo Iury/F-5873-2016;
   Santos, Flavia/S-5321-2016
OI RAPOSO, RAMON/0000-0002-6374-1442; De Sa Roriz Caminha,
   Juan/0000-0001-8913-8636; Gomes Nunes, Paulo Iury/0000-0003-2996-4340;
   Santos, Flavia/0000-0003-3625-8540; Crespo-Lopez, Maria
   Elena/0000-0002-1335-6853; Rodrigues Roque, Cassia/0000-0001-8367-2061
FU Brazilian National Council for Scientific and Technological Development
   (CNPq); Coordination for the Improvement of Higher Education Personnel
   (CAPES) [PROCAD 88881.068408/2014-01]
FX The authors acknowledge the financial support of the Brazilian National
   Council for Scientific and Technological Development (CNPq),
   Coordination for the Improvement of Higher Education Personnel (CAPES)
   PROCAD 88881.068408/2014-01.
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NR 57
TC 8
Z9 8
U1 2
U2 12
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0300-483X
J9 TOXICOLOGY
JI Toxicology
PD DEC
PY 2021
VL 464
AR 152992
DI 10.1016/j.tox.2021.152992
EA OCT 2021
PG 9
WC Pharmacology & Pharmacy; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Toxicology
GA WV1AS
UT WOS:000716969900003
PM 34670124
DA 2025-06-11
ER

PT J
AU Dasilva, G
   Pazos, M
   García-Egido, E
   Gallardo, JM
   Ramos-Romero, S
   Torres, JL
   Romeu, M
   Nogués, MR
   Medina, I
AF Dasilva, Gabriel
   Pazos, Manuel
   Garcia-Egido, Eduardo
   Gallardo, Jose M.
   Ramos-Romero, Sara
   Lluis Torres, Josep
   Romeu, Marta
   Nogues, Maria-Rosa
   Medina, Isabel
TI A lipidomic study on the regulation of inflammation and oxidative stress
   targeted by marine ω-3 PUFA and polyphenols in high-fat high-sucrose
   diets
SO JOURNAL OF NUTRITIONAL BIOCHEMISTRY
LA English
DT Article
DE Eicosanoids; Docosanoids; Fish oils; Polyphenols; Inflammation;
   Oxidative stress
ID C-REACTIVE PROTEIN; PERFORMANCE LIQUID-CHROMATOGRAPHY; FISH-OIL;
   ADIPOSE-TISSUE; GENE-EXPRESSION; IN-VIVO; INSULIN-RESISTANCE; METABOLIC
   SYNDROME; RAT MODEL; N-3 PUFA
AB The ability of polyphenols to ameliorate potential oxidative damage of omega-3 PUFAs when they are consumed together and then, to enhance their potentially individual effects on metabolic health is discussed through the modulation of fatty acids profiling and the production of lipid mediators. For that, the effects of the combined consumption of fish oils and grape seed procyanidins on the inflammatory response and redox unbalance triggered by high-fat high-sucrose (HFHS) diets were studied in an animal model of Wistar rats. A standard diet was used as control. Results suggested that fish oils produced a replacement of (omega)-6 by omega-3 PUFAs in membranes and tissues, and consequently they improved inflammatory and oxidative stress parameters: favored the activity of 12/15lipoxygenases on omega-3 PUFAs, enhanced glutathione peroxidases activity, modulated proinflammatory lipid mediators synthesis through the cyclooxygenase (COX) pathways and down-regulated the synthesis de novo of ARA leaded by Delta 5 desaturase. Although polyphenols exerted an antioxidative and antiinflammatory effect in the standard diet, they were less effective to reduce inflammation in the HFHS dietary model. Contrary to the effect observed in the standard diet, polyphenols up-regulated COX pathways toward omega-6 proinflammatory eicosanoids as PGE(2) and 11-HETE and decreased the detoxification of omega-3 hydroperoxides in the HFHS diet. As a result, additive effects between fish oils and polyphenols were found in the standard diet in terms of reducing inflammation and oxidative stress. However, in the HFHS diets, fish oils seem to be the one responsible for the positive effects found in the combined group. (C) 2017 Elsevier Inc. All rights reserved.
C1 [Dasilva, Gabriel; Pazos, Manuel; Garcia-Egido, Eduardo; Gallardo, Jose M.; Medina, Isabel] IIM CSIC, E-36208 Vigo, Galicia, Spain.
   [Dasilva, Gabriel] Univ Santiago de Compostela, Dept Analyt Chem Nutr & Bromatol, E-15782 Santiago De Compostela, Galicia, Spain.
   [Dasilva, Gabriel] Univ Santiago de Compostela, Res Inst Food Anal IIAA, E-15782 Santiago De Compostela, Galicia, Spain.
   [Ramos-Romero, Sara; Lluis Torres, Josep] CSIC, IQAC, Jordi Girona 18-26, E-08034 Barcelona, Spain.
   [Romeu, Marta; Nogues, Maria-Rosa] Univ Rovira & Virgili, Fac Med, Unidad Farmacol, St Llorenc 21, E-43201 Reus, Spain.
C3 Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Instituto
   de Investigaciones Marinas (IIM); Universidade de Santiago de
   Compostela; Universidade de Santiago de Compostela; Consejo Superior de
   Investigaciones Cientificas (CSIC); CSIC - Centro de Investigacion y
   Desarrollo Pascual Vila (CID-CSIC); CSIC - Instituto de Quimica Avanzada
   de Cataluna (IQAC); Universitat Rovira i Virgili
RP Dasilva, G (corresponding author), IIM CSIC, E-36208 Vigo, Galicia, Spain.
EM gabrieldasilvaalonso@gmail.com
RI Nogués, M./ABH-5645-2020; MEDINA, ISABEL/AAL-4012-2021; Ramos-Romero,
   Sara/AAH-6209-2020; ROMEU, MARTA/O-7129-2019; ROMEU, MARTA/A-8468-2014;
   Pazos, Manuel/N-5007-2014; Ramos-Romero, Sara/K-8301-2017; Torres,
   Josep/N-7256-2013
OI ROMEU, MARTA/0000-0002-2131-1858; MEDINA, ISABEL/0000-0002-1854-3359;
   Pazos, Manuel/0000-0003-1571-5730; Ramos-Romero,
   Sara/0000-0002-9293-4454; Torres, Josep/0000-0002-5072-8265; dasilva,
   gabriel/0000-0002-1098-7262
FU Spanish Ministry of Science and Innovation [AGL2013-49079-C2-1-R];
   Consejo Superior de Investigaciones Cientificas (CSIC); University of
   Santiago de Compostela (USC); European Social Fund; Xunta de Galicia
FX This work was supported by the Spanish Ministry of Science and
   Innovation (grants AGL2013-49079-C2-1-R). The Consejo Superior de
   Investigaciones Cientificas (CSIC) and the University of Santiago de
   Compostela (USC) are gratefully acknowledged for the doctoral fellowship
   to G. D. and postdoctoral contract to E. G. Xunta de Galicia and
   European Social Fund are also thankfully recognized by the financial
   support of the postdoctoral "Isidro Parga Pondal" contract to M. P. The
   authors thank Lucia Mendez for her excellent assistance and discussion
   of results, Pilar Comesafia and Maria Jesus Gonzalez for her excellent
   technical assistance and Eunice Molinar for her contribution to the
   animal experiment.
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NR 112
TC 24
Z9 24
U1 0
U2 30
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0955-2863
EI 1873-4847
J9 J NUTR BIOCHEM
JI J. Nutr. Biochem.
PD MAY
PY 2017
VL 43
BP 53
EP 67
DI 10.1016/j.jnutbio.2017.02.007
PG 15
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA EU5DV
UT WOS:000401052700007
PM 28260647
DA 2025-06-11
ER

PT J
AU Dean, J
   Dela Cruz, S
   Mehta, PK
   Merz, CNB
AF Dean, Jenna
   Dela Cruz, Sherwin
   Mehta, Puja K.
   Merz, C. Noel Bairey
TI Coronary microvascular dysfunction: sex-specific risk, diagnosis, and
   therapy
SO NATURE REVIEWS CARDIOLOGY
LA English
DT Review
ID ISCHEMIC-HEART-DISEASE; FLOW VELOCITY RESERVE; CARDIAC SYNDROME-X;
   CONVERTING ENZYME-INHIBITION; SYNDROME EVALUATION WISE; ST-SEGMENT
   DEPRESSION; TRANSTHORACIC DOPPLER-ECHOCARDIOGRAPHY; CARDIOVASCULAR
   MAGNETIC-RESONANCE; SUSPECTED MYOCARDIAL-ISCHEMIA; SPINAL-CORD
   STIMULATION
AB Cardiovascular disease is the leading cause of death worldwide. In the presence of signs and symptoms of myocardial ischaemia, women are more likely than men to have no obstructive coronary artery disease (CAD). Women have a greater burden of symptoms than men, and are often falsely reassured despite the presence of ischaemic heart disease because of a lack of obstructive CAD. Coronary microvascular dysfunction should be considered as an aetiology for ischaemic heart disease with signs and symptoms of myocardial ischaemia, but no obstructive CAD. Coronary microvascular dysfunction is defined as impaired coronary flow reserve owing to functional and/or structural abnormalities of the microcirculation, and is associated with an adverse cardiovascular prognosis. Therapeutic lifestyle changes as well as antiatherosclerotic and antianginal medications might be beneficial, but clinical outcome trials are needed to guide treatment. In this Review, we discuss the prevalence, presentation, diagnosis, and treatment of coronary microvascular dysfunction, with a particular emphasis on ischaemic heart disease in women.
C1 [Dean, Jenna; Dela Cruz, Sherwin; Mehta, Puja K.; Merz, C. Noel Bairey] Cedars Sinai Med Ctr, Cedars Sinai Heart Inst, Barbra Streisand Womens Heart Ctr, Los Angeles, CA 90048 USA.
C3 Cedars Sinai Medical Center
RP Merz, CNB (corresponding author), Cedars Sinai Med Ctr, Cedars Sinai Heart Inst, Barbra Streisand Womens Heart Ctr, 127 South San Vicente Blvd,A3600, Los Angeles, CA 90048 USA.
EM noel.baireymerz@cshs.org
FU National Heart, Lung, and Blood Institute [N01-HV-68161, N01-HV-68162,
   N01-HV-68163, N01-HV-68164]; National Institute on Aging [K23HL105787,
   U0164829, U01 HL649141, U01 HL649241, T32HL69751, R01 HL090957,
   1R03AG032631]; GCRC grant from National Center for Research Resources
   [M01-RR00425]; Gustavus and Louis Pfeiffer Research Foundation,
   Danville, NJ, USA; Women's Guild of Cedars-Sinai Medical Center, Los
   Angeles, CA, USA; Ladies Hospital Aid Society of Western Pennsylvania,
   Pittsburgh, PA, USA; QMED, Inc., Laurence Harbor, NJ, USA; Edythe L.
   Broad Women's Heart Research Fellowship; Barbra Streisand Women's
   Cardiovascular Research and Education Program; Linda Joy Pollin Women's
   Heart Health Program, Cedars-Sinai Medical Center, Los Angeles, CA, USA
FX The authors were supported by funding from the National Heart, Lung, and
   Blood Institute, numbers N01-HV-68161, N01-HV-68162, N01-HV-68163, and
   N01-HV-68164; grants K23HL105787, U0164829, U01 HL649141, U01 HL649241,
   T32HL69751, R01 HL090957, and 1R03AG032631 from the National Institute
   on Aging; GCRC grant M01-RR00425 from the National Center for Research
   Resources; and grants from the Gustavus and Louis Pfeiffer Research
   Foundation, Danville, NJ, USA; The Women's Guild of Cedars-Sinai Medical
   Center, Los Angeles, CA, USA; The Ladies Hospital Aid Society of Western
   Pennsylvania, Pittsburgh, PA, USA; QMED, Inc., Laurence Harbor, NJ, USA;
   the Edythe L. Broad Women's Heart Research Fellowship; the Barbra
   Streisand Women's Cardiovascular Research and Education Program; and the
   Linda Joy Pollin Women's Heart Health Program, Cedars-Sinai Medical
   Center, Los Angeles, CA, USA.
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NR 154
TC 88
Z9 99
U1 2
U2 34
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 1759-5002
EI 1759-5010
J9 NAT REV CARDIOL
JI Nat. Rev. Cardiol.
PD JUL
PY 2015
VL 12
IS 7
BP 406
EP 414
DI 10.1038/nrcardio.2015.72
PG 9
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA CK9UA
UT WOS:000356583800006
PM 26011377
DA 2025-06-11
ER

PT J
AU Yang, HT
   Luo, LJ
   Chen, WJ
   Zhao, L
   Tang, CS
   Qi, YF
   Zhang, J
AF Yang, Hong-Tao
   Luo, Li-Jie
   Chen, Wen-Jia
   Zhao, Lei
   Tang, Chao-Shu
   Qi, Yong-Fen
   Zhang, Jing
TI IL-15 expression increased in response to treadmill running and
   inhibited endoplasmic reticulum stress in skeletal muscle in rats
SO ENDOCRINE
LA English
DT Article
DE Interleukin-15; Treadmill running; Insulin resistance; Skeletal muscle;
   Endoplasmic reticulum stress
ID INDUCED INSULIN-RESISTANCE; UNFOLDED PROTEIN RESPONSE;
   GLUCOSE-HOMEOSTASIS; ADIPOSE-TISSUE; PPAR-DELTA; ER STRESS; METABOLIC
   SYNDROME; POTENTIAL ROLE; MALE-MICE; INTERLEUKIN-15
AB Interleukin 15 (IL-15) has recently been proposed as a circulating myokine involved in glucose uptake and utilization in skeletal muscle. However, the role and mechanism of IL-15 in exercise improving insulin resistance (IR) is unclear. Here, we investigated the alteration in expression of IL-15 and IL-15 receptor alpha (IL-15R alpha) in skeletal muscle during treadmill running in rats with IR induced by a high-fat diet (HFD) and elucidated the mechanism of the anti-IR effects of IL-15. At 20 weeks of HFD, rats showed severe IR, with increased levels of fasting blood sugar and plasma insulin, impaired glucose tolerance, and reduced glucose transport activity. IL-15 immunoreactivity and mRNA level in gastrocnemius muscle were decreased markedly as compared with controls. IL-15R alpha protein and mRNA levels in both soleus and gastrocnemius muscle were significantly decreased, which might attenuate the signaling or secretion of IL-15 in muscle. Eight-week treadmill running completely ameliorated HFD-induced IR and reversed the downregulated level of IL-15 and IL-15R alpha in skeletal muscle of HFD-fed rats. To investigate whether IL-15 exerts its anti-IR effects directly in muscle, we pre-incubated muscle strips with the endoplasmic reticulum stress (ERS) inducer dithiothreitol (DTT) or tunicamycin (Tm); IL-15 treatment markedly decreased the protein expression of the ERS markers 78-kDa glucose-regulated protein, 94-kDa glucose-regulated protein and C/EBP homologous protein and inhibited ERS induced by DTT or Tm. Therefore, treadmill running promoted skeletal IL-15 and IL-15R alpha expression in HFD-induced IR in rats. The inhibitory effect of IL-15 on ERS may be involved in improved insulin sensitivity with exercise training.
C1 [Yang, Hong-Tao; Zhang, Jing] Beijing Normal Univ, Sch PE & Sports Sci, Beijing 100875, Peoples R China.
   [Luo, Li-Jie] Qufu Normal Univ, Rizhao 273165, Shandong, Peoples R China.
   [Chen, Wen-Jia] Harbin Med Univ, Affiliated Hosp 1, Dept Cardiol, Harbin 150001, Peoples R China.
   [Zhao, Lei; Tang, Chao-Shu; Qi, Yong-Fen] Peking Univ, Hlth Sci Ctr, Minist Educ, Key Lab Mol Cardiovasc Sci, Beijing 100191, Peoples R China.
C3 Beijing Normal University; Qufu Normal University; Harbin Medical
   University; Ministry of Education - China; Peking University
RP Zhang, J (corresponding author), Beijing Normal Univ, Sch PE & Sports Sci, Beijing 100875, Peoples R China.
EM zhangjing@bnu.edu.cn
FU National Natural Science Foundation of China [81270921, 81170082]
FX This work was supported by the National Natural Science Foundation of
   China (Grant nos. 81270921 and 81170082).
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NR 54
TC 17
Z9 22
U1 0
U2 13
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1355-008X
EI 1559-0100
J9 ENDOCRINE
JI Endocrine
PD FEB
PY 2015
VL 48
IS 1
BP 152
EP 163
DI 10.1007/s12020-014-0233-y
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA CB0RQ
UT WOS:000349334800023
PM 24647688
DA 2025-06-11
ER

PT J
AU Prieto, D
   Contreras, C
   Sánchez, A
AF Prieto, Dolores
   Contreras, Cristina
   Sanchez, Ana
TI Endothelial Dysfunction, Obesity and Insulin Resistance
SO CURRENT VASCULAR PHARMACOLOGY
LA English
DT Article
DE Endothelial dysfunction; endothelin-1; inflammation; nitric oxide;
   insulin resistance; obesity; oxidative stress; perivascular adipose
   tissue
ID NITRIC-OXIDE SYNTHASE; TUMOR-NECROSIS-FACTOR; PERIVASCULAR
   ADIPOSE-TISSUE; FREE FATTY-ACIDS; SKELETAL-MUSCLE ARTERIOLES; INCREASED
   OXIDATIVE STRESS; DIET-INDUCED OBESITY; DEPENDENT VASODILATION;
   CORONARY-ARTERIES; PENILE ARTERIES
AB Obesity is a metabolic disorder of increasing prevalence worldwide and a risk factor for the development of insulin resistance (IR), metabolic syndrome and type 2 diabetes. Obesity is related to endothelial dysfunction through indirect mechanisms such as IR and the associated risk factors, and through direct mechanisms including the production of proinflammatory adipokines and elevated levels of free fatty acids (FFAs) by adipose tissue. Both clinical and experimental studies using genetic and diet-induced animal models of obesity have consistently shown impaired metabolic, agonistor flow-induced vasodilatations correlated with the amount of visceral adipose tissue and improved by dietary interventions and exercise. Compromised bioavailability of NO due to oxidative stress emerges as a main cause of endothelial dysfunction in obesity. Inflamed adipose tissue due to hypoxia, and in particular perivascular adipose tissue (PVAT), secrete larger amounts of reactive oxygen species (ROS) and adipokines that deteriorate NO signaling pathways. Abnormal production and activity of the vasoconstrictor/proatherogenic peptide endothelin-1 (ET-1) is also a hallmark of the obesity-associated endothelial dysfunction. Obesity, and in particular visceral obesity, is one of the main causes of IR, and the pathogenic factors that induce endothelial dysfunction in the earlier stages of obesity will further deteriorate the insulin signaling pathways in endothelial cells thus leading to blunted vasodilatation and abnormal capillary recruitment and substrate delivery by insulin to the target tissues. The present review is an attempt to summarize the current knowledge and the latest novel findings on the pathogenic mechanisms underlying endothelial dysfunction in obesity, in particular the local contribution of oxidative stress and inflammatory response from PVAT, and its role in the obesity-associated cardiovascular and metabolic complications.
C1 [Prieto, Dolores; Contreras, Cristina; Sanchez, Ana] Univ Complutense, Fac Pharm, Dept Physiol, E-28040 Madrid, Spain.
C3 Complutense University of Madrid
RP Prieto, D (corresponding author), Univ Complutense, Fac Pharm, Dept Physiol, E-28040 Madrid, Spain.
EM dprieto@farm.ucm.es
RI Contreras, Cristina/N-7257-2019; PRIETO, DOLORES/S-8172-2018
OI Contreras, Cristina/0000-0002-7015-7922; PRIETO,
   DOLORES/0000-0001-7049-5991
FU Spanish Ministerio de Ciencia e Innovacian (Spain) [SAF2009-10448];
   MINECO (Spain) [SAF2012-31631]
FX Authors' research was funded by grants SAF2009-10448 from the Spanish
   Ministerio de Ciencia e Innovacian (Spain) and SAF2012-31631 from MINECO
   (Spain).
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NR 205
TC 135
Z9 147
U1 0
U2 25
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1570-1611
EI 1875-6212
J9 CURR VASC PHARMACOL
JI Current Vascular Pharmacology
PY 2014
VL 12
IS 3
BP 412
EP 426
DI 10.2174/1570161112666140423221008
PG 15
WC Pharmacology & Pharmacy; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Cardiovascular System & Cardiology
GA AW4UI
UT WOS:000346275400009
PM 24846231
DA 2025-06-11
ER

PT J
AU Bel, JS
   Tai, TC
   Khaper, N
   Lees, SJ
AF Bel, Jocelyn S.
   Tai, T. C.
   Khaper, Neelam
   Lees, Simon J.
TI Chronic glucocorticoid exposure causes brown adipose tissue whitening,
   alters whole-body glucose metabolism and increases tissue uncoupling
   protein-1
SO PHYSIOLOGICAL REPORTS
LA English
DT Article
DE corticosterone; insulin resistance; metabolic syndrome; mirabegron;
   obesity; UCP-1
ID CHRONIC CORTICOSTERONE; INSULIN-RESISTANCE; ENERGY-EXPENDITURE; INDUCED
   OBESITY; CHRONIC STRESS; MOUSE MODEL; THERMOGENESIS
AB Adipose tissue (AT) has been found to exist in two predominant forms, white and brown. White adipose tissue (WAT) is the body's conventional storage organ, and brown adipose tissue (BAT) is responsible for non-shivering thermogenesis which allows mammals to produce heat and regulate body temperature. Studies examining BAT and its role in whole-body metabolism have found that active BAT utilizes glucose and circulating fatty acids and is associated with improved metabolic outcomes. While the beiging of WAT is a growing area of interest, the possibility of the BAT depot to "whiten" and store more triglycerides also has metabolic and health implications. Currently, there are limited studies that examine the effects of chronic stress and its ability to induce a white-like phenotype in the BAT depot. This research examined how chronic exposure to the murine stress hormone, corticosterone, for 4 weeks can affect the whitening process of BAT in C57BL/6 male mice. Separate treatments with mirabegron, a known beta 3-adrenergic receptor agonist, were used to directly compare the effects of corticosterone with a beiging phenotype. Corticosterone-treated mice had significantly higher body weight (p <= 0.05) and BAT mass (p <= 0.05), increased adipocyte area (p <= 0.05), were insulin resistant (p < 0.05), and significantly elevated expressions of uncoupling protein 1 (UCP-1) in BAT (p <= 0.05) while mitochondrial content remained unchanged. This whitened phenotype has not been previously associated with increased uncoupling proteins under chronic stress and may represent a compensatory mechanism being initiated under these conditions. These findings have implications for the study of BAT in response to chronic glucocorticoid exposure potentially leading to BAT dysfunction and negative impacts on whole-body glucose metabolism.
C1 [Bel, Jocelyn S.] Lakehead Univ, Biotechnol Program, Thunder Bay, ON, Canada.
   [Tai, T. C.; Khaper, Neelam; Lees, Simon J.] Northern Ontario Sch Med, Thunder Bay, ON, Canada.
   [Tai, T. C.] Laurentian Univ, Biol, Sudbury, ON, Canada.
   [Tai, T. C.] Laurentian Univ, Chem & Biochem, Sudbury, ON, Canada.
   [Tai, T. C.; Khaper, Neelam] Laurentian Univ, Biomol Sci Program, Sudbury, ON, Canada.
   [Khaper, Neelam; Lees, Simon J.] Lakehead Univ, Biol, Thunder Bay, ON, Canada.
C3 Lakehead University; NOSM University; Laurentian University; Laurentian
   University; Laurentian University; Lakehead University
RP Lees, SJ (corresponding author), Northern Ontario Sch Med, Thunder Bay, ON, Canada.
EM simon.lees@nosm.ca
OI Bel, Jocelyn Susan/0000-0002-0683-4597
FU Natural Sciences and Engineering Research Council of Canada CRD
   [CRDPJ/494077-16]; Nuclear Innovation Institute
FX This work was supported by the Natural Sciences and Engineering Research
   Council of Canada CRD (Grant number CRDPJ/494077--16) and the Nuclear
   Innovation Institute. Graphical abstract was created with BioRender.com.
CR Alcalá M, 2017, SCI REP-UK, V7, DOI 10.1038/s41598-017-16463-6
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NR 46
TC 11
Z9 11
U1 1
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2051-817X
J9 PHYSIOL REP
JI PHYSIOL. REP.
PD MAY
PY 2022
VL 10
IS 9
AR e15292
DI 10.14814/phy2.15292
PG 16
WC Physiology
WE Emerging Sources Citation Index (ESCI)
SC Physiology
GA 0Y9JY
UT WOS:000790700200001
PM 35510321
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Liang, YZ
   Li, JJH
   Xiao, HB
   He, Y
   Zhang, L
   Yan, YX
AF Liang, Ying-Zhi
   Li, Jia-Jiang-Hui
   Xiao, Huan-Bo
   He, Yan
   Zhang, Ling
   Yan, Yu-Xiang
TI Identification of stress-related microRNA biomarkers in type 2 diabetes
   mellitus: A systematic review and meta-analysis
SO JOURNAL OF DIABETES
LA English
DT Review
DE meta-analysis; microRNA; review; stress; type 2 diabetes mellitus
ID BLOOD MONONUCLEAR-CELLS; SMOOTH-MUSCLE-CELLS; DIFFERENTIAL EXPRESSION;
   INFLAMMATORY MARKERS; MINIMUM INFORMATION; NLRP3 INFLAMMASOME;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; DOWN-REGULATION; PATHOGENESIS
AB Background Many studies have investigated microRNAs (miRNAs) in the detection of type 2 diabetes mellitus (T2DM). Herein, the dysregulated direction of stress-related miRNAs used as biomarkers of T2DM are summarized and analyzed. Methods PubMed, EMBASE, ISI Web of Science, and three Chinese databases were searched for case-control miRNA profiling studies about T2DM. A meta-analysis under a random effect was performed. Subgroup analysis was conducted based on different tissues and species. Sensitivity analysis was conducted to confirm the robustness among studies. The effect size was pooled using ln odds ratios (ORs), 95% confidence intervals (95% CIs), andP-values. Results The present meta-analysis included 39 case-control studies with a total of 494 miRNAs. Only 33 miRNAs were reported in three or more studies and, of these, 18 were inconsistent in their direction of dysregulation. Two significantly dysregulated miRNAs (let-7 g and miR-155) were identified in the meta-analysis. Four miRNAs (miR-142-3p, miR-155, miR-21, and miR-34c-5p) were dysregulated in patients with T2DM, whereas five miRNAs (miR-146a, miR-199a-3p, miR-200b, miR-29b and miR-30e) were dysregulated in animal models of diabetes. In addition, two dysregulated miRNAs (miR-146a and miR-21) were highly cornea specific and heart specific. In sensitivity analysis, only miR-155 was still significantly dysregulated after removing studies with small sample sizes. Conclusions The present meta-analysis revealed that 16 stress-related miRNAs were significantly dysregulated in T2DM. MiR-148b, miR-223, miR-130a, miR-19a, miR-26b and miR-27b were selected as potential circulating biomarkers of T2DM. In addition, miR-146a and miR-21 were identified as potential tissue biomarkers of T2DM.
C1 [Liang, Ying-Zhi; Li, Jia-Jiang-Hui; He, Yan; Zhang, Ling; Yan, Yu-Xiang] Capital Med Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, 10 Xitoutiao, Beijing 100069, Peoples R China.
   [Liang, Ying-Zhi; Li, Jia-Jiang-Hui; He, Yan; Zhang, Ling; Yan, Yu-Xiang] Municipal Key Lab Clin Epidemiol, Beijing, Peoples R China.
   [Xiao, Huan-Bo] Capital Med Univ, Yanjing Med Coll, Dept Prevent Med, Beijing, Peoples R China.
C3 Capital Medical University; Capital Medical University
RP Yan, YX (corresponding author), Capital Med Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, 10 Xitoutiao, Beijing 100069, Peoples R China.
EM yanyxepi@ccmu.edu.cn
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NR 92
TC 44
Z9 47
U1 0
U2 12
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1753-0393
EI 1753-0407
J9 J DIABETES
JI J. Diabetes
PD SEP
PY 2020
VL 12
IS 9
BP 633
EP 644
DI 10.1111/1753-0407.12643
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA MV4ZA
UT WOS:000556366900002
PM 29341487
OA Bronze
DA 2025-06-11
ER

PT J
AU Jaksic, M
   Martinovic, M
   Gligorovic-Barhanovic, N
   Vujacic, A
   Djurovic, D
   Nedovic-Vukovic, M
AF Jaksic, Marina
   Martinovic, Milica
   Gligorovic-Barhanovic, Najdana
   Vujacic, Aleksandar
   Djurovic, Dijana
   Nedovic-Vukovic, Mirjana
TI Association between inflammation, oxidative stress, vitamin D, copper
   and zinc with pre-obesity and obesity in school children from the city
   of Podgorica, Montenegro
SO JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
LA English
DT Article
DE inflammation; obesity; oligoelements; oxidative stress; vitamin D
ID METABOLIC SYNDROME; D DEFICIENCY; MARKERS; DYSFUNCTION; ADOLESCENTS;
   OVERWEIGHT; ADIPOSITY; RETINOL; INSULIN
AB Background: Childhood obesity is a serious health condition with increasing rates worldwide. The aim of this study was to investigate the association between inflammation, oxidative stress, vitamin D, copper and zinc in pre-obese and obese children compared to controls.
   Methods: The study involved 202 children aged 7-15 years (63.9% boys), randomly chosen from 10 elementary schools in Podgorica, Montenegro. Participants were divided into three groups according to their nutritional status (International Obesity Task Force [IOTF] criteria): normal-weight (42.1%), pre-obese (40.6%) and obese (17.3%). Serum biochemical analyses were performed (C-reactive protein [CRP], retinol-binding protein [RBP], total antioxidant status [TAS], total vitamin D [VD], copper and zinc).
   Results: Serum TAS and CRP concentrations were higher in pre-obese and obese children compared to controls (p < 0.001). Serum VD concentrations were lower in pre-obese and obese children compared to their normal-weight peers (p = 0.027 and p = 0.054, respectively). Copper, zinc and RBP concentrations did not differ significantly among the groups (p > 0.05). In pre-obese and obese children, a positive correlation was found between CRP and copper (r = 0.305, p = 0.011 and r = 0.440, p = 0.013, respectively), and TAS and RBP (r = 0.528, p < 0.001 and r = 0.434, p = 0.015, respectively). Standard regression analyses showed that CRP and TAS increase (p < 0.001) whereas VD decreases (p = 0.011) with the body mass index (BMI).
   Conclusions: We show that pre-obesity and obesity in childhood are positively associated with oxidative stress and inflammation, and inversely associated with VD status. Copper and zinc concentrations were not associated with excess fat in children.
C1 [Jaksic, Marina] Inst Childrens Dis, Dept Lab Diagnost, Podgorica, Montenegro.
   [Martinovic, Milica] Univ Montenegro, Fac Med, Dept Pathophysiol & Lab Med, Podgorica, Montenegro.
   [Gligorovic-Barhanovic, Najdana] Clin Ctr Montenegro, Ctr Lab Diagnost, Podgorica, Montenegro.
   [Vujacic, Aleksandar; Djurovic, Dijana] Inst Publ Hlth, Ctr Human Ecol, Dept Sanit Chem, Podgorica, Montenegro.
   [Nedovic-Vukovic, Mirjana] Inst Publ Hlth, Ctr Hlth Syst Dev, Dept Hlth Stat & Informat, Podgorica, Montenegro.
C3 University of Montenegro
RP Jaksic, M (corresponding author), Inst Childrens Dis, Dept Lab Diagnost, Podgorica, Montenegro.
EM marinajaksic@ymail.com
RI Jaksic, Marina/ABC-7114-2020
FU Montenegrin Ministry of Science [1366/2012]
FX The study was financially supported by the Montenegrin Ministry of
   Science, Contract No. 1366/2012.
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NR 36
TC 24
Z9 25
U1 0
U2 3
PU WALTER DE GRUYTER GMBH
PI BERLIN
PA GENTHINER STRASSE 13, D-10785 BERLIN, GERMANY
SN 0334-018X
EI 2191-0251
J9 J PEDIATR ENDOCR MET
JI J. Pediatr. Endocrinol. Metab.
PD SEP
PY 2019
VL 32
IS 9
BP 951
EP 957
DI 10.1515/jpem-2019-0086
PG 7
WC Endocrinology & Metabolism; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Pediatrics
GA JF1FU
UT WOS:000491133800005
PM 31444965
DA 2025-06-11
ER

PT J
AU Simperova, A
   Al-Nakkash, L
   Faust, JJ
   Sweazea, KL
AF Simperova, Anna
   Al-Nakkash, Layla
   Faust, James J.
   Sweazea, Karen L.
TI Genistein supplementation prevents weight gain but promotes oxidative
   stress and inflammation in the vasculature of female obese
   ob/ob mice
SO NUTRITION RESEARCH
LA English
DT Article
DE Genistein; Obese mouse; Reactive oxygen species; Superoxide; Obesity;
   Oxidative stress; Arteries
ID CARDIOVASCULAR-DISEASE RISK; ENDOTHELIAL DYSFUNCTION; METABOLIC
   SYNDROME; NITRIC-OXIDE; SUPEROXIDE-DISMUTASE; INSULIN-RESISTANCE;
   ADIPOSE-TISSUE; SOY PROTEIN; FAT; HYDROETHIDINE
AB Obesity, a state of chronic low-grade inflammation, is strongly associated with the development of hypertension and diabetes. Superoxide, a free radical elevated in obese individuals, promotes hypertension through scavenging the endogenous vasodilator nitric oxide. The hypothesis was a genistein-enriched diet would promote weight loss and reduce oxidative stress and inflammation in the vasculature of intact female ob/ob mice. Aortas and mesenteric arteries were isolated from female ob/ob mice fed genistein-free (0 mg genistein/kg diet; n = 6), standard chow (200-300 mg genistein/kg diet; n = 11) or genistein-enriched (600 mg genistein/kg diet; n = 9) diets for 4 weeks. Sections of isolated vessels were labeled with the superoxide indicator dihydroethidium and fluorescence was measured by confocal microscopy. Protein expression of the inflammatory marker inducible nitric oxide synthase (iNOS) was measured in the perivascular adipose tissue (PVAT) surrounding each vessel and plasma concentrations of superoxide dismutase (SOD) were quantified. Genistein-enriched diet promoted less weight gain compared to animals fed standard chow (P = .008). Standard chow promoted increased superoxide in the aorta (P = .030) and mesenteric arteries (P = .024) compared to a diet devoid of genistein. At all tested concentrations, genistein significantly increased iNOS expression in mesenteric artery PVAT (vs. standard chow, P < .001; vs. genistein-enriched, P = .002) and tended to increase iNOS within the aortic PVAT (standard chow, P = .075) compared to the genistein-free group. Plasma SOD activity was significantly downregulated in genistein-enriched animals as compared to those fed a genistein-free diet (P = .028). In summary, although genistein prevents weight gain, it promotes vascular oxidative stress and inflammation in obese ovarian-intact female mice. (C) 2016 Elsevier Inc. All rights reserved.
C1 [Simperova, Anna; Faust, James J.; Sweazea, Karen L.] Arizona State Univ, Sch Life Sci, Tempe, AZ USA.
   [Al-Nakkash, Layla] Midwestern Univ, Arizona Coll Osteopath Med, Dept Physiol, Glendale, AZ USA.
   [Sweazea, Karen L.] Arizona State Univ, Sch Nutr & Hlth Promot, Tempe, AZ USA.
C3 Arizona State University; Arizona State University-Tempe; Midwestern
   University; Midwestern University - Glendale; Arizona State University;
   Arizona State University-Tempe
RP Sweazea, KL (corresponding author), Arizona State Univ, 401 E Tyler Mall,Mail Code 4501, Tempe, AZ 85287 USA.
EM Karen.Sweazea@asu.edu
RI Sweazea, Karen/AAT-4151-2020; Al-Nakkash, Layla/GLR-3517-2022
OI Sweazea, Karen/0000-0003-0345-4086
FU Barrett; Honors College at Arizona State University; School of Life
   Sciences Undergraduate Research (SOLUR) program at ASU
FX The authors would like to thank Barrett, the Honors College at Arizona
   State University and the School of Life Sciences Undergraduate Research
   (SOLUR) program at ASU for providing funding to support this study. We
   thank Matthew Calhoun (currently University of Arizona College of
   Medicine, Phoenix), Zoha Ahmed (Arizona State University), and Kristin
   Ricklefs (currently Mayo Clinic Hospital) for technical assistance with
   the study. We are grateful for Debra Baluch's (Arizona State University)
   assistance with confocal microscopy. We also appreciate Rayna Gonzales'
   (University of Arizona College of Medicine, Phoenix) helpful discussion
   of the project.
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NR 62
TC 13
Z9 16
U1 0
U2 5
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0271-5317
J9 NUTR RES
JI Nutr. Res.
PD AUG
PY 2016
VL 36
IS 8
BP 789
EP 797
DI 10.1016/j.nutres.2016.03.011
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA DT9RB
UT WOS:000381838900004
PM 27440533
DA 2025-06-11
ER

PT J
AU Sun, SJ
   Wang, JS
   Lu, Y
   Dai, JY
AF Sun, Sujie
   Wang, Jianshe
   Lu, Yin
   Dai, Jiayin
TI Corticosteroid-binding globulin, induced in testicular Leydig cells by
   perfluorooctanoic acid, promotes steroid hormone synthesis
SO ARCHIVES OF TOXICOLOGY
LA English
DT Article
DE Perfluorooctanoic acid; Progesterone; Leydig cell;
   Corticosteroid-binding globulin
ID HUMAN SEMEN QUALITY; FLUOROCHEMICAL PRODUCTION WORKERS;
   INSULIN-RESISTANCE SYNDROME; PERFLUOROALKYL ACIDS; GENE-EXPRESSION;
   CHRONIC STRESS; MAMMARY-GLAND; PFOA EXPOSURE; MICE; CORTISOL
AB Perfluorooctanoic acid (PFOA) is an abundant perfluoroalkyl substance widely applied in industrial and consumer products. It is a ubiquitous environmental pollutant and suspected endocrine disruptor. Corticosteroid-binding globulin (CBG) is a monomeric glycoprotein that can bind specifically to anti-inflammatory steroids, such as glucocorticoids and progesterone, in circulation. Our previous proteomic profile analysis revealed that CBG levels increased in testes after PFOA treatment. In the present study, we verified its increase in mouse testes following oral exposure to PFOA (0, 1.25 and 5 mg/kg/day for 28 days) by immunohistochemical analysis and Western blotting. In addition, RNA fluorescence in situ hybridization (FISH) confirmed that testicular CBG was specifically expressed in Leydig cells. Serum CBG levels in all three PFOA groups also increased, accompanied by increased corticosterone in the 5 and 20 mg/kg/day groups and decreased adrenocorticotropic hormone in the 20 mg/kg/day group. Thus, the influence of PFOA on blood CBG may change free steroid hormone concentrations, thereby serving as an endocrine disruptor. A stimulation effect of PFOA on CBG was also observed in vitro using the Leydig tumor mLTC-1 cell line. Overexpression of CBG in mLTC-1 cells increased progesterone release in culture media. In addition, CBG-induced proteins involved in steroidogenesis in mLTC-1 cells, including steroidogenic acute regulatory protein (StAR), cytochrome P450 cholesterol side-chain cleavage enzyme (CYP11A1), 17 alpha-hydroxylase/17,20 lyase (CYP17A1), and 3 beta-hydroxysteroid dehydrogenase (3 beta-HSD), which may be the mechanism behind increased progesterone. Furthermore, the production and release of CBG in mLTC-1 cells were also induced by luteinizing hormone, though this mechanism requires further exploration.
C1 [Sun, Sujie; Wang, Jianshe; Lu, Yin; Dai, Jiayin] Chinese Acad Sci, Inst Zool, Key Lab Anim Ecol & Conservat Biol, Beijing 100101, Peoples R China.
   [Sun, Sujie] Univ Chinese Acad Sci, Beijing 100049, Peoples R China.
C3 Chinese Academy of Sciences; Institute of Zoology, CAS; Chinese Academy
   of Sciences; University of Chinese Academy of Sciences, CAS
RP Wang, JS (corresponding author), Chinese Acad Sci, Inst Zool, Key Lab Anim Ecol & Conservat Biol, Beijing 100101, Peoples R China.
EM jianshewang@ioz.ac.cn
RI Wang, Jianshe/E-9313-2013; Dai, Jiayin/C-6654-2012
FU National Natural Science Foundation of China [31320103915, 21737004,
   21377128]
FX This work was supported by the National Natural Science Foundation of
   China (31320103915, 21737004, and 21377128). We thank Prof. Geoffrey L.
   Hammond from the Departments of Cellular and Physiological Sciences and
   Obstetrics and Gynaecology, University of British Columbia, Canada, for
   providing CBG antibodies.
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NR 85
TC 13
Z9 16
U1 4
U2 49
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0340-5761
EI 1432-0738
J9 ARCH TOXICOL
JI Arch. Toxicol.
PD JUN
PY 2018
VL 92
IS 6
BP 2013
EP 2025
DI 10.1007/s00204-018-2207-y
PG 13
WC Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Toxicology
GA GJ4RC
UT WOS:000435367800009
PM 29721586
DA 2025-06-11
ER

PT J
AU Li, YC
   Li, CL
   Qi, JY
   Huang, LN
   Shi, D
   Du, SS
   Liu, LY
   Feng, RN
   Sun, CH
AF Li, Yan-Chuan
   Li, Chun-Long
   Qi, Jia-Yue
   Huang, Li-Na
   Shi, Dan
   Du, Shan-Shan
   Liu, Li-Yan
   Feng, Ren-Nan
   Sun, Chang-Hao
TI Relationships of Dietary Histidine and Obesity in Northern Chinese
   Adults, an Internet-Based Cross-Sectional Study
SO NUTRIENTS
LA English
DT Article
DE dietary histidine; overweight/obesity; insulin resistance; inflammation;
   oxidative stress
ID FOOD FREQUENCY QUESTIONNAIRE; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   OXIDATIVE STRESS; ADIPOSE-TISSUE; BLOOD-PRESSURE; AMINO-ACIDS;
   INFLAMMATION; PROTEIN; WOMEN
AB Our previous studies have demonstrated that histidine supplementation significantly ameliorates inflammation and oxidative stress in obese women and high-fat diet-induced obese rats. However, the effects of dietary histidine on general population are not known. The objective of this Internet-based cross-sectional study was to evaluate the associations between dietary histidine and prevalence of overweight/obesity and abdominal obesity in northern Chinese population. A total of 2376 participants were randomly recruited and asked to finish our Internet-based dietary questionnaire for the Chinese (IDQC). Afterwards, 88 overweight/obese participants were randomly selected to explore the possible mechanism. Compared with healthy controls, dietary histidine was significantly lower in overweight (p < 0.05) and obese (p < 0.01) participants of both sexes. Dietary histidine was inversely associated with body mass index (BMI), waist circumference (WC) and blood pressure in overall population and stronger associations were observed in women and overweight/obese participants. Higher dietary histidine was associated with lower prevalence of overweight/obesity and abdominal obesity, especially in women. Further studies indicated that higher dietary histidine was associated with lower fasting blood glucose (FBG), homeostasis model assessment of insulin resistance (HOMA-IR), 2-h postprandial glucose (2 h-PG), tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1 beta), interleukin-6 (IL-6), C-reactive protein (CRP), malonaldehyde (MDA) and vaspin and higher glutathione peroxidase (GSH-Px), superoxide dismutase (SOD) and adiponectin of overweight/obese individuals of both sexes. In conclusion, higher dietary histidine is inversely associated with energy intake, status of insulin resistance, inflammation and oxidative stress in overweight/obese participants and lower prevalence of overweight/obesity in northern Chinese adults.
C1 [Li, Yan-Chuan; Qi, Jia-Yue; Shi, Dan; Du, Shan-Shan; Liu, Li-Yan; Feng, Ren-Nan; Sun, Chang-Hao] Harbin Med Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, 157 Baojian Rd, Harbin 150086, Peoples R China.
   [Li, Chun-Long] Harbin Med Univ, Affiliated Hosp 2, Dept Gen Surg, Harbin 150086, Peoples R China.
   [Huang, Li-Na] Liaoning Inst Food Control, Shenyang 110015, Peoples R China.
C3 Harbin Medical University; Harbin Medical University
RP Feng, RN; Sun, CH (corresponding author), Harbin Med Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, 157 Baojian Rd, Harbin 150086, Peoples R China.
EM liyanchuan2013@foxmail.com; chunlong81@163.com; qijiayue678@163.com;
   lnspjcy@163.com; shidanhmu@foxmail.com; dushanshan1007@163.com;
   yanziliu2100@163.com; fengrennan@163.com; changhao2002sun@gmail.com
RI Jiayue, Qi/AAE-1545-2019; Shi, Dan/HDM-7580-2022; lina,
   huang/AAZ-9488-2021; Chunlong, Li/AAM-8644-2021
OI Shi, Dan/0000-0002-8585-1669
FU National Natural Science Fund of China [81202184, 81573133]; Natural
   Science Fund of Heilongjiang Province [JJ2016ZR1154, H2016018]; China
   Postdoctoral Science Foundation [2013M531076]
FX The study was supported by the National Natural Science Fund of China
   (No. 81202184, 81573133), Natural Science Fund of Heilongjiang Province
   (No. JJ2016ZR1154, No. H2016018) and Financial Grant from China
   Postdoctoral Science Foundation (2013M531076).
CR [Anonymous], AM J CLIN NUTR
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NR 40
TC 33
Z9 34
U1 1
U2 19
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JUL
PY 2016
VL 8
IS 7
AR 420
DI 10.3390/nu8070420
PG 15
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA DS4QP
UT WOS:000380766200037
PM 27409634
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Wang, HT
   Liu, CF
   Tsai, TH
   Chen, YL
   Chang, HW
   Tsai, CY
   Leu, S
   Zhen, YY
   Chai, HT
   Chung, SY
   Chua, S
   Yen, CH
   Yip, HK
AF Wang, Hui-Ting
   Liu, Chu-Feng
   Tsai, Tzu-Hsien
   Chen, Yung-Lung
   Chang, Hsueh-Wen
   Tsai, Ching-Yen
   Leu, Steve
   Zhen, Yen-Yi
   Chai, Han-Tan
   Chung, Sheng-Ying
   Chua, Sarah
   Yen, Chia-Hung
   Yip, Hon-Kan
TI Effect of obesity reduction on preservation of heart function and
   attenuation of left ventricular remodeling, oxidative stress and
   inflammation in obese mice
SO JOURNAL OF TRANSLATIONAL MEDICINE
LA English
DT Article
DE Obesity; Inflammation; Oxidative stress; Apoptosis; Fibrosis
ID CARDIOVASCULAR RISK-FACTORS; BODY-MASS INDEX; DIABETIC CARDIOMYOPATHY;
   METABOLIC SYNDROME; WEIGHT-REDUCTION; IMPACT; CELLS; COMORBIDITIES;
   OVERWEIGHT; PROTEIN
AB Background: Obesity is an important cardiovascular risk factor. This study tested the effect of obesity reduction on preserving left ventricular ejection fraction (LVEF) and attenuating inflammation, oxidative stress and LV remodeling in obese mice.
   Methods and results: Eight-week-old C57BL/6 J mice (n=24) were equally divided into control (fed a control diet for 22 weeks), obesity (high-fat diet, 22 weeks), and obese reduction (OR) (high-fat diet, 14 weeks; then control diet, 8 weeks). Animals were sacrificed at post 22-week high-fat diet and the LV myocardium collected. Heart weight, body weight, abdominal-fat weight, total cholesterol level and fasting blood glucose were higher in obesity than in control and OR (all p<0.001). Inflammation measured by mRNA expressions of IL-6, MMP-9, PAI-1 and leptin and protein expression of NF-kappa B was higher, whereas anti-inflammation measured by mRNA expressions of adiponectin and INF-gamma was lower in obesity than in control and OR (all p<0.003). Oxidative protein expressions of NOX-1, NOX-2 and oxidized protein were higher, whereas expression of anti-oxidant markers HO-1 and NQO-1 were lower (all p<0.01); and apoptosis measured by Bax and caspase 3 was higher, whereas anti-apoptotic Bcl-2 was lower in obesity as compared with control and OR (all p<0.001). The expressions of fibrotic markers phosphorylated Smad3 and TGF-beta were higher, whereas expression of anti-fibrotic phosphorylated Smad1/5 and BMP-2 were lower (all p<0.02); and LVEF was lower, whereas the LV remodeling was higher in obesity than in control and OR (all p<0.001).
   Conclusion: Impaired LVEF, enhanced LV remodeling, inflammation, fibrosis, oxidative stress and apoptosis were reversed by reduction in mouse obesity.
C1 [Wang, Hui-Ting; Liu, Chu-Feng] Kaohsiung Chang Gung Mem Hosp, Dept Emergency Med, Kaohsiung, Taiwan.
   [Wang, Hui-Ting; Liu, Chu-Feng; Tsai, Tzu-Hsien; Chen, Yung-Lung; Leu, Steve; Zhen, Yen-Yi; Chai, Han-Tan; Chung, Sheng-Ying; Chua, Sarah; Yip, Hon-Kan] Chang Gung Univ, Coll Med, Kaohsiung, Taiwan.
   [Tsai, Tzu-Hsien; Chen, Yung-Lung; Chai, Han-Tan; Chung, Sheng-Ying; Chua, Sarah; Yip, Hon-Kan] Kaohsiung Chang Gung Mem Hosp, Dept Internal Med, Div Cardiol, Kaohsiung, Taiwan.
   [Chang, Hsueh-Wen] Natl Sun Yat Sen Univ, Dept Biol Sci, Kaohsiung 80424, Taiwan.
   [Tsai, Ching-Yen] Acad Sinica, Inst Mol Biol, Taipei 115, Taiwan.
   [Leu, Steve; Zhen, Yen-Yi; Yip, Hon-Kan] Kaohsiung Chang Gung Mem Hosp, Ctr Translat Res Biomed Sci, Kaohsiung, Taiwan.
   [Yen, Chia-Hung] Natl Pingtung Univ Sci & Technol, Dept Biol Sci & Technol, Pingtung, Taiwan.
C3 Chang Gung Memorial Hospital; Chang Gung University; Chang Gung Memorial
   Hospital; National Sun Yat Sen University; Academia Sinica - Taiwan;
   Chang Gung Memorial Hospital; National Pingtung University Science &
   Technology
RP Yen, CH (corresponding author), Natl Pingtung Univ Sci & Technol, Dept Biol Sci & Technol, Pingtung, Taiwan.
EM chyen0326@yahoo.com.tw; han.gung@msa.hinet.net
RI Chen, Chien-Jen/C-6976-2008; Chiang, Shu-Chiung/GPX-6643-2022; Leu,
   Steve/D-6807-2011; Chen, YuChun/L-1052-2019; Tsai,
   Ching-Yen/AEX-9366-2022
OI Leu, Steve/0000-0002-1738-1028; Tsai, Ching-Yen/0000-0001-7964-6661
FU Chang Gung Memorial Hospital, Chang Gung University [CMRPG890641]
FX This study was supported by a program grant from Chang Gung Memorial
   Hospital, Chang Gung University (Grant number: CMRPG890641).
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NR 38
TC 46
Z9 51
U1 0
U2 10
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1479-5876
J9 J TRANSL MED
JI J. Transl. Med.
PD JUL 11
PY 2012
VL 10
AR 145
DI 10.1186/1479-5876-10-145
PG 13
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 074TF
UT WOS:000313835900001
PM 22784636
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Tagliamonte, E
   Sperlongano, S
   Montuori, C
   Riegler, L
   Scarafile, R
   Carbone, A
   Forni, A
   Radmilovic, J
   Di Vilio, A
   Astarita, R
   Cice, G
   D'Andrea, A
AF Tagliamonte, Ercole
   Sperlongano, Simona
   Montuori, Caterina
   Riegler, Lucia
   Scarafile, Raffaella
   Carbone, Andreina
   Forni, Alberto
   Radmilovic, Juri
   Di Vilio, Alessandro
   Astarita, Roberta
   Cice, Gennaro
   D'Andrea, Antonello
TI Coronary microvascular dysfunction affects left ventricular global
   longitudinal strain response to dipyridamole stress echocardiography: a
   pilot study
SO HEART AND VESSELS
LA English
DT Article
DE Coronary microvascular dysfunction (CMD); Coronary flow reserve (CFR);
   Dipyridamole stress echocardiography; Global longitudinal strain (GLS);
   Ischemia and no obstructive coronary artery disease (INOCA); Speckle
   tracking echocardiography (STE); Contractile reserve
ID CARDIOVASCULAR MAGNETIC-RESONANCE; CARDIAC SYNDROME-X;
   MYOCARDIAL-ISCHEMIA; ARTERY-DISEASE; FLOW RESERVE; VELOCITY RESERVE;
   PROGNOSTIC VALUE; ANGINA-PECTORIS; WOMEN; HEART
AB The aim is to investigate, by means of speckle tracking echocardiography, left ventricular (LV) contractile function at rest and during dipyridamole stress in patients with coronary microvascular dysfunction (CMD). 59 patients (39% women, mean age 65.6 +/- 6.1 years) with history of chest pain and without obstructive coronary artery disease (CAD) underwent dipyridamole stress echocardiography. Coronary flow was assessed in the left anterior descending coronary artery. Coronary flow reserve (CFR) was determined as the ratio of hyperaemic to baseline diastolic coronary flow velocity. CMD was defined as CFR < 2. Global longitudinal strain (GLS) was measured at rest and at peak dose. Nineteen patients (32%) among the overall population showed CMD. Baseline GLS was significantly lower in patients with CMD (- 16.8 +/- 2.7 vs. - 19.1 +/- 3.1, p < 0.01). A different contractile response to dipyridamole infusion was observed between the two groups: GLS significantly increased up to peak dose in patients without CMD (from - 19.1 +/- 3.1 to - 20.2 +/- 3.1, p < 0.01), and significantly decreased in patients with CMD (from - 16.8 +/- 2.7 to - 15.8 +/- 2.7, p < 0.01). There was a significant inverse correlation between CFR and increment GLS (r = - 0.82, p < 0.01). Rest GLS and GLS response to dipyridamole stress are markedly impaired among patients with chest pain syndrome, non-obstructive CAD and CMD, reflecting subclinical LV systolic dysfunction and lack of LV contractile reserve due to underlying myocardial ischemia.
C1 [Tagliamonte, Ercole; Riegler, Lucia; Scarafile, Raffaella; Forni, Alberto; Radmilovic, Juri; D'Andrea, Antonello] Umberto I Hosp, Dept Cardiol & Intens Coronary Care, Viale San Francesco 2, I-84014 Nocera Inferiore, SA, Italy.
   [Sperlongano, Simona; Carbone, Andreina; Di Vilio, Alessandro] Univ Campania Luigi Vanvitelli, Div Cardiol, Dept Translat Med Sci, Naples, Italy.
   [Montuori, Caterina] San Giuliano Hosp, Div Cardiol, Naples, Italy.
   [Astarita, Roberta] CEDIM Lab, Naples, Italy.
   [Cice, Gennaro] IRCSS San Raffaele Pisana, Div Cardiol, Rome, Italy.
C3 Universita della Campania Vanvitelli; IRCCS San Raffaele Pisana
RP Tagliamonte, E (corresponding author), Umberto I Hosp, Dept Cardiol & Intens Coronary Care, Viale San Francesco 2, I-84014 Nocera Inferiore, SA, Italy.
EM ercoletagliamonte@gmail.com
RI Carbone, Andreina/AFZ-2546-2022; Sperlongano, Simona/AAH-1564-2021
OI Di Vilio, Alessandro/0000-0002-2885-410X
CR Cadeddu C, 2014, J AM SOC ECHOCARDIOG, V27, P208, DOI 10.1016/j.echo.2013.09.014
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NR 25
TC 8
Z9 10
U1 0
U2 1
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0910-8327
EI 1615-2573
J9 HEART VESSELS
JI Heart Vessels
PD APR
PY 2023
VL 38
IS 4
BP 470
EP 477
DI 10.1007/s00380-022-02191-z
EA NOV 2022
PG 8
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 9O5RW
UT WOS:000884162000001
PM 36380229
DA 2025-06-11
ER

PT J
AU Murthy, VL
   Yu, B
   Wang, WS
   Zhang, XY
   Alkis, T
   Pico, AR
   Yeri, A
   Bhupathiraju, SN
   Bressler, J
   Ballantyne, CM
   Freedman, JE
   Ordovas, J
   Boerwinkle, E
   Tucker, KL
   Shah, R
AF Murthy, Venkatesh L.
   Yu, Bing
   Wang, Wenshuang
   Zhang, Xiuyan
   Alkis, Taryn
   Pico, Alexander R.
   Yeri, Ashish
   Bhupathiraju, Shilpa N.
   Bressler, Jan
   Ballantyne, Christie M.
   Freedman, Jane E.
   Ordovas, Jose
   Boerwinkle, Eric
   Tucker, Katherine L.
   Shah, Ravi
TI Molecular Signature of Multisystem Cardiometabolic Stress and Its
   Association With Prognosis
SO JAMA CARDIOLOGY
LA English
DT Article
ID ATHEROSCLEROSIS RISK; ENZYMATIC DETERMINATION; ALLOSTATIC LOAD;
   SUPPLEMENTATION; MORTALITY; PATHWAY; NRF2; METABOLOMICS; CHOLESTEROL;
   PROFILES
AB IMPORTANCE Cardiometabolic disease is responsible for decreased longevity and poorer cardiovascular outcomes in the modern era. Metabolite profiling provides a specific measure of global metabolic function to examine specific metabolic mechanisms and pathways of cardiometabolic disease beyond its clinical definitions.
   OBJECTIVES To define a molecular basis for cardiometabolic stress and assess its association with cardiovascular prognosis.
   DESIGN, SETTING, AND PARTICIPANTS A prospective observational cohort study was conducted in a population-based setting across 2 geographically distinct centers (Boston Puerto Rican Health Study [BPRHS], an ongoing study of individuals enrolled between June 1, 2004, and October 31, 2009; and Atherosclerosis Risk in Communities [ARIC] study, whose participants were originally sampled between November 24, 1986, and February 10, 1990, and followed up through December 31, 2017). Participants in the BPRHS were 668 Puerto Rican individuals with metabolite profiling living in Massachusetts, and participants in the ARIC study were 2152 individuals with metabolite profiling and long-term follow-up for mortality and cardiovascular outcomes. Statistical analysis was performed from October 1, 2018, to March 13, 2020.
   EXPOSURE The primary exposure was metabolite profiles across both cohorts.
   MAIN OUTCOMES AND MEASURES Outcomes included associations with multisystem cardiometabolic stress and all-cause mortality and incident coronary heart disease (in the ARIC study).
   RESULTS Participants in the BPRHS (N = 668; 491 women; mean [SD] age, 57.0 [7.4] years; mean [SD] body mass index [calculated as weight in kilograms divided by height in meters squared], 32.0 [6.5]) had higher prevalent cardiometabolic risk relative to those in the ARIC study (N = 2152; 599 African American individuals; 1213 women; mean [SD] age, 54.3 [5.7] years; mean [SD] body mass index, 28.0 [5.5]). Multisystem cardiometabolic stress was defined for 668 Puerto Rican individuals in the BPRHS as a multidimensional composite of hypothalamic-adrenal axis activity, sympathetic activation, blood pressure, proatherogenic dyslipidemia, insulin resistance, visceral adiposity, and inflammation. A total of 260 metabolites associated with cardiometabolic stress were identified in the BPRHS, involving known and novel pathways of cardiometabolic disease (eg, amino acid metabolism, oxidative stress, and inflammation). A parsimonious metabolite-based score associated with cardiometabolic stress in the BPRHS was subsequently created; this score was applied to shared metabolites in the ARIC study, demonstrating significant associations with coronary heart disease and all-cause mortality after multivariable adjustment at a 30-year horizon (per SD increase in metabolomic score: hazard ratio, 1.14; 95% CI, 1.00-1.31; P = .045 for coronary heart disease; and hazard ratio, 1.15; 95% CI, 1.07-1.24; P < .001 for all-cause mortality).
   CONCLUSIONS AND RELEVANCE Metabolites associated with cardiometabolic stress identified known and novel pathways of cardiometabolic disease in high-risk, community-based cohorts and were associated with coronary heart disease and survival at a 30-year time horizon. These results underscore the shared molecular pathophysiology of metabolic dysfunction, cardiovascular disease, and longevity and suggest pathways for modification to improve prognosis across all linked conditions.
C1 [Murthy, Venkatesh L.] Univ Michigan, Frankel Cardiovasc Ctr, Dept Internal Med, Div Cardiovasc Med, Ann Arbor, MI USA.
   [Yu, Bing; Wang, Wenshuang; Alkis, Taryn; Bressler, Jan; Boerwinkle, Eric] Univ Texas Hlth Sci Ctr Houston, Dept Epidemiol Human Genet & Environm Sci, Sch Publ Hlth, Houston, TX USA.
   [Zhang, Xiuyan; Tucker, Katherine L.] Univ Massachusetts, Dept Biomed & Nutr Sci, Lowell, MA USA.
   [Pico, Alexander R.] Gladstone Inst, Inst Data Sci & Biotechnol, San Francisco, CA USA.
   [Yeri, Ashish; Shah, Ravi] Massachusetts Gen Hosp, Dept Med, Cardiol Div, 55 Fruit St, Boston, MA 02114 USA.
   [Bhupathiraju, Shilpa N.] Harvard Sch Publ Hlth, Dept Nutr, Boston, MA USA.
   [Bhupathiraju, Shilpa N.] Harvard Med Sch, Brigham & Womens Hosp, Channing Div Network Med, Boston, MA USA.
   [Ballantyne, Christie M.] Baylor Coll Med, Dept Med, Houston, TX USA.
   [Freedman, Jane E.] Univ Massachusetts, Med Sch, UMass Mem Heart & Vasc Ctr, Worcester, MA USA.
   [Ordovas, Jose] Tufts Univ, Friedman Sch Nutr Sci & Policy, Sch Grad Biomed Sci, Boston, MA 02111 USA.
C3 University of Michigan System; University of Michigan; University of
   Texas System; University of Texas Health Science Center Houston;
   University of Texas School Public Health; University of Massachusetts
   System; University of Massachusetts Lowell; University of California
   System; University of California San Francisco; The J David Gladstone
   Institutes; Harvard University; Harvard University Medical Affiliates;
   Massachusetts General Hospital; Harvard University; Harvard T.H. Chan
   School of Public Health; Harvard University; Harvard University Medical
   Affiliates; Brigham & Women's Hospital; Harvard Medical School; Baylor
   College of Medicine; University of Massachusetts System; University of
   Massachusetts Worcester; Tufts University
RP Shah, R (corresponding author), Massachusetts Gen Hosp, Dept Med, Cardiol Div, 55 Fruit St, Boston, MA 02114 USA.
EM rvshah@partners.org
RI Bhupathiraju, Shilpa/I-1209-2013; Zhang, Xiyuan/AHB-1487-2022; Tucker,
   Katherine/A-4545-2010; Boerwinkle, Eric/B-9599-2015; Pico,
   Alexander/HCH-4305-2022; Ballantyne, Christie/A-6599-2008; Shah,
   Ravi/KLD-0068-2024; Murthy, Venkatesh/B-3448-2013; Freedman,
   Jane/KLC-3446-2024
OI Shah, Ravi/0000-0002-4471-7156; Murthy, Venkatesh/0000-0002-7901-1321;
   Tucker, Katherine/0000-0001-7640-662X; Freedman,
   Jane/0000-0002-0011-6164; Ballantyne, Christie/0000-0002-6432-1730
FU American Heart Association [17SDG33661228]; National Heart, Lung, and
   Blood Institute [P50-HL105185]; National Institute on Aging
   [P01-AG023394, R01-AG055948]; National Heart, Lung, and Blood Institute,
   National Institutes of Health, Department of Health and Human Services
   [HHSN268201700001I, HHSN268201700002I, HHSN268201700003I,
   HHSN268201700005I, HHSN268201700004I]; National Genome Research
   Institute [HG004402]; National Institutes of Health [K01 DK107804];
   American Heart Association (AHA) [17SDG33661228] Funding Source:
   American Heart Association (AHA)
FX Drs Murthy, Yu, Pico, Bhupathiraju, Bressler, Ballantyne, Freedman,
   Boerwinkle, Tucker, and Shah received grants from the National
   Institutes of Health. Dr Yu is also supported by grant 17SDG33661228
   from the American Heart Association. The Boston Puerto Rican Health
   study has been funded by grant P50-HL105185 from the National Heart,
   Lung, and Blood Institute and grants P01-AG023394 and R01-AG055948 from
   the National Institute on Aging. The Atherosclerosis Risk in Communities
   study has been funded in whole or in part with federal funds from the
   National Heart, Lung, and Blood Institute, National Institutes of
   Health, Department of Health and Human Services, under contract
   HHSN268201700001I, HHSN268201700002I, HHSN268201700003I,
   HHSN268201700005I, and HHSN268201700004I. The metabolomics measurements
   were supported by grant HG004402 from the National Genome Research
   Institute and by grant K01 DK107804 from the National Institutes of
   Health (Dr Bhupathiraju; for the Boston Puerto Rican Health Study).
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NR 45
TC 14
Z9 15
U1 0
U2 6
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 2380-6583
EI 2380-6591
J9 JAMA CARDIOL
JI JAMA Cardiol.
PD OCT
PY 2020
VL 5
IS 10
BP 1144
EP 1153
DI 10.1001/jamacardio.2020.2686
PG 10
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA OQ4GM
UT WOS:000588743700013
PM 32717046
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Zhu, ZH
   Yang, ZM
   Zhang, XH
   Yu, LH
   Yang, DD
   Guo, FJ
   Meng, L
   Xu, LS
   Wu, YH
   Li, TZ
   Lin, YY
   Shen, P
   Lin, HB
   Shui, LM
   Tang, ML
   Jin, MJ
   Wang, JB
   Chen, K
AF Zhu, Zhanghang
   Yang, Zongming
   Zhang, Xinhan
   Yu, Luhua
   Yang, Dandan
   Guo, Fanjia
   Meng, Lin
   Xu, Lisha
   Wu, Yonghao
   Li, Tiezheng
   Lin, Yaoyao
   Shen, Peng
   Lin, Hongbo
   Shui, Liming
   Tang, Mengling
   Jin, Mingjuan
   Wang, Jianbing
   Chen, Kun
TI Association of walkability and NO2 with metabolic syndrome: A cohort
   study in China
SO ENVIRONMENT INTERNATIONAL
LA English
DT Article
DE Walkability; Nitrogen dioxide; MetS; Prospective cohort study; China
ID INSULIN-RESISTANCE; PHYSICAL-ACTIVITY; NEIGHBORHOOD WALKABILITY; SOCIAL
   INEQUALITIES; OXIDATIVE STRESS; AIR-POLLUTION; RISK; HEALTH;
   COMMUNITIES; VALIDATION
AB Background: Epidemiological studies have reported an association between traffic-related pollution with risk of metabolic syndrome (MetS). However, evidence from prospective studies on the association of walkability and nitrogen dioxide (NO2) with MetS is still scarce. We, therefore, aimed to evaluate the association of long-term exposure to NO2 and walkability with hazards of incident MetS.Methods: A total of 17,965 participants without MetS diagnosed within one year at baseline were included in our study from a population-based prospective cohort in Yinzhou District, Ningbo, Zhejiang Province, China. Par-ticipants were followed up by the regional Health Information System (HIS) until December 15, 2021. MetS was defined based on the criteria of Chinese Diabetes Society (CDS2004). We used walkscore tools, calculating with amenity categories and decay functions, and spatial-temporal land-use regression (LUR) models to estimate walkability and NO2 concentrations. We used Cox proportional hazards regression models to examine the as-sociation of walkability and NO2 with hazards of MetS incidence reporting with hazard ratios (HRs) and 95% confidence intervals (CIs).Results: Overall, we followed up 77,303 person-years and identified 4040 incident cases of MetS in the entire cohort. Higher walkability was inversely associated with incident MetS (HR = 0.94, 95 % CI: 0.91-0.99), whereas NO2 was positively associated with MetS incidence (HR = 1.07, 95 %CI: 1.00-1.15) per interquartile range increment in two-exposure models. Furthermore, we found a significant multiplicative interaction between walkability and NO2. Stronger associations were observed for NO2 and incident MetS among men, smokers, drinkers and participants who aged < 60 years and had higher levels of income.Conclusion: In summary, we found living in areas with lower walkability and higher concentrations of NO2 were associated with increased incidence of MetS. The beneficial effect of higher walkability may be attenuated by exposure to NO2.
C1 [Zhu, Zhanghang; Zhang, Xinhan; Yang, Dandan; Guo, Fanjia; Jin, Mingjuan; Chen, Kun] Zhejiang Univ, Affiliated Hosp 2, Dept Publ Hlth, Sch Med, Hangzhou 310058, Peoples R China.
   [Yang, Zongming; Yu, Luhua; Xu, Lisha; Wu, Yonghao; Li, Tiezheng; Wang, Jianbing] Zhejiang Univ, Dept Publ Hlth, Sch Med, Hangzhou 310058, Peoples R China.
   [Yang, Zongming; Yu, Luhua; Xu, Lisha; Wu, Yonghao; Li, Tiezheng; Wang, Jianbing] Zhejiang Univ, Childrens Hosp, Dept Natl Clin Res, Sch Med,Ctr Child Hlth, Hangzhou 310058, Peoples R China.
   [Meng, Lin; Lin, Yaoyao; Tang, Mengling] Zhejiang Univ, Affiliated Hosp 4, Dept Publ Hlth, Sch Med, Hangzhou 310058, Peoples R China.
   [Shen, Peng; Lin, Hongbo] Yinzhou Dist Hlth Bur Ningbo, Ningbo 315040, Peoples R China.
   [Shui, Liming] Yinzhou Dist Ctr Dis Control & Prevent, Dept Chron Dis & Hlth Promot, Ningbo 315040, Peoples R China.
   [Chen, Kun] Zhejiang Univ, Affiliated Hosp 2, Dept Publ Hlth, Sch Med, 866 Yuhangtang Rd, Hangzhou 310058, Peoples R China.
   [Wang, Jianbing] Zhejiang Univ, Dept Publ Hlth, Sch Med, 866 Yuhangtang Rd, Hangzhou 310058, Peoples R China.
   [Wang, Jianbing] Zhejiang Univ, Childrens Hosp, Dept Natl Clin Res, Sch Med,Ctr Child Hlth, 866 Yuhangtang Rd, Hangzhou 310058, Peoples R China.
C3 Zhejiang University; Zhejiang University; Zhejiang University; Zhejiang
   University; Zhejiang University; Zhejiang University; Zhejiang
   University
RP Chen, K (corresponding author), Zhejiang Univ, Affiliated Hosp 2, Dept Publ Hlth, Sch Med, Hangzhou 310058, Peoples R China.; Wang, JB (corresponding author), Zhejiang Univ, Dept Publ Hlth, Sch Med, Hangzhou 310058, Peoples R China.; Chen, K (corresponding author), Zhejiang Univ, Affiliated Hosp 2, Dept Publ Hlth, Sch Med, 866 Yuhangtang Rd, Hangzhou 310058, Peoples R China.; Wang, JB (corresponding author), Zhejiang Univ, Dept Publ Hlth, Sch Med, 866 Yuhangtang Rd, Hangzhou 310058, Peoples R China.; Wang, JB (corresponding author), Zhejiang Univ, Childrens Hosp, Dept Natl Clin Res, Sch Med,Ctr Child Hlth, 866 Yuhangtang Rd, Hangzhou 310058, Peoples R China.
EM wangjianbing@zju.edu.cn; ck@zju.edu.cn
RI Guo, Fanjia/KLC-5379-2024; Liu, Hongbo/H-2790-2013; Zhong,
   Hongliang/LDE-6340-2024; Tang, Mengling/N-1066-2014; Chen,
   Shanshan/M-5985-2013
FU National Science Foundation of China [NSFC] [82173587]; Health
   Commission of Ningbo [2021Y60]
FX Funding Sources This research was supported by the National Science
   Foundation of China [NSFC, grant number: 82173587] and Health Commission
   of Ningbo [grant number: 2021Y60] .
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NR 62
TC 3
Z9 3
U1 1
U2 34
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0160-4120
EI 1873-6750
J9 ENVIRON INT
JI Environ. Int.
PD JAN
PY 2023
VL 171
AR 107731
DI 10.1016/j.envint.2023.107731
EA JAN 2023
PG 9
WC Environmental Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology
GA 7Z8XA
UT WOS:000915834700001
PM 36610356
OA gold
DA 2025-06-11
ER

PT J
AU Higuchi, N
   Kato, M
   Tanaka, M
   Miyazaki, M
   Takao, S
   Kohjima, M
   Kotoh, K
   Enjoji, M
   Nakamuta, M
   Takayanagi, R
AF Higuchi, Nobito
   Kato, Masaki
   Tanaka, Masatake
   Miyazaki, Masayuki
   Takao, Shinichiro
   Kohjima, Motoyuki
   Kotoh, Kazuhiro
   Enjoji, Munechika
   Nakamuta, Makoto
   Takayanagi, Ryoichi
TI Effects of insulin resistance and hepatic lipid accumulation on hepatic
   mRNA expression levels of apoB, MTP and L-FABP in non-alcoholic fatty
   liver disease
SO EXPERIMENTAL AND THERAPEUTIC MEDICINE
LA English
DT Article
DE apolipoprotein B; fatty-acid binding protein; homeostasis model
   assessment of insulin resistance; microsomal triglyceride transfer
   protein; non-alcoholic fatty liver disease; very low-density lipoprotein
ID TRIGLYCERIDE TRANSFER PROTEIN; NF-KAPPA-B; TRANSCRIPTIONAL REGULATION;
   METABOLIC SYNDROME; GENE-EXPRESSION; NUCLEAR FACTOR-4-ALPHA;
   ADIPOSE-TISSUE; RECEPTOR; OBESITY; STRESS
AB Non-alcoholic fatty liver disease (NAFLD) is considered a hepatic manifestation of metabolic syndrome, which is known to be associated with insulin resistance (IR). NAFLD occurs when the rate of hepatic fatty acid uptake from plasma and de novo fatty acid synthesis is greater than the rate of fatty acid oxidation and excretion as very low-density lipoprotein (VLDL). To estimate the effects of IR on hepatic lipid excretion, mRNA expression levels of genes involved in VLDL assembly were analyzed in NAFLD liver. Twenty-two histologically proven NAFLD patients and 10 healthy control subjects were enrolled in this study. mRNA was extracted from liver biopsy samples and real-time PCR was performed to quantify the expression levels of apolipoprotein B (apoB), microsomal triglyceride transfer protein (MTP) and liver fatty-acid binding protein (L-FABP). Hepatic expression levels of the genes were compared between NAFLD patients and control subjects. In NA FLD patients, we also examined correlations between expression levels of the genes and metabolic factors, including IR, and the extent of obesity and hepatic lipid accumulation. Hepatic expression levels of apoB, MTP and L-FABP were significantly up-regulated in NAFLD patients compared to control subjects. The expression levels of MTP were correlated with those of apoB, but not with those of L-FA BP. In the NA FLD liver, the expression levels of MTP were significantly reduced in patients with HOMA-IR >2.5. In addition, a significant reduction in MTP expression was observed in livers with advanced steatosis. Enhanced expression of genes involved in VLDL assembly may be promoted to release excess lipid from NAFLD livers. However, the progression of IR and hepatic steatosis may attenuate this compensatory process.
C1 [Kato, Masaki] Kyushu Univ, Dept Med & Bioregulatory Sci, Grad Sch Med Sci, Higashi Ku, Fukuoka 8128582, Japan.
   [Enjoji, Munechika] Fukuoka Univ, Dept Clin Pharmacol, Fac Pharmaceut Sci, Fukuoka 8140180, Japan.
   [Nakamuta, Makoto] Natl Hosp Org, Dept Gastroenterol, Kyushu Med Ctr, Fukuoka 8108563, Japan.
C3 Kyushu University; Fukuoka University
RP Kato, M (corresponding author), Kyushu Univ, Dept Med & Bioregulatory Sci, Grad Sch Med Sci, Higashi Ku, 3-1-1 Maidashi, Fukuoka 8128582, Japan.
EM mkatoll@intmed3.med.kyushu-u.ac.jp
RI Tanaka, Masatake/NIU-3174-2025
OI Tanaka, Masatake/0000-0001-7461-0678
FU Grants-in-Aid for Scientific Research [21590850] Funding Source: KAKEN
CR Améen C, 2005, J BIOL CHEM, V280, P1224, DOI 10.1074/jbc.M412107200
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NR 29
TC 79
Z9 88
U1 0
U2 13
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1792-0981
J9 EXP THER MED
JI Exp. Ther. Med.
PD NOV-DEC
PY 2011
VL 2
IS 6
BP 1077
EP 1081
DI 10.3892/etm.2011.328
PG 5
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 828ZG
UT WOS:000295543400009
PM 22977624
OA Bronze, Green Accepted, Green Published
DA 2025-06-11
ER

PT J
AU Li, QH
   Lai, XF
   Sun, LL
   Cao, JX
   Ling, CJ
   Zhang, WJ
   Xiang, LM
   Chen, RH
   Li, DL
   Sun, SL
AF Li, Qiuhua
   Lai, Xingfei
   Sun, Lingli
   Cao, Junxi
   Ling, Caijin
   Zhang, Wenji
   Xiang, Limin
   Chen, Ruohong
   Li, Dongli
   Sun, Shili
TI Antiobesity and anti-inflammation effects of Hakka stir-fried tea of
   different storage years on high-fat diet-induced obese mice model via
   activating the AMPK/ACC/CPT1 pathway
SO FOOD & NUTRITION RESEARCH
LA English
DT Article
DE Hakka stir-fried tea; obesity; inflammation; fat accumulation; hepatic
   steatosis; AMPK/ACC/CPT1 pathway
ID GREEN TEA; METABOLIC SYNDROME; CARDIOVASCULAR-DISEASE; OXIDATIVE STRESS;
   LIPID-METABOLISM; BODY-FAT; EXTRACT; RISK; POLYPHENOL; CATECHINS
AB Background: As a typical representative of metabolic syndrome, obesity is also one of the extremely dangerous factors of cardiovascular diseases. Thus, the prevention and treatment of obesity has gradually become a global campaign. There have been many reports that green tea is effective in preventing obesity, but as a kind of green tea with regional characteristics, there have been no reports that Hakka stir-fried tea (HT) of different storage years has a weight loss effect.
   Aims: The aim was to investigate the effect of HT in diet-induced obese mice.
   Methods: The mice were divided into five groups as follows: the control group received normal diet; the obese model group received high-fat diet; and HT2003, HT2008, and HT2015 groups, after the induction of obesity via a high-fat diet, received HT of different storage years treatment for 6 weeks, respectively.
   Results: It was observed that HT decreased the levels of serum and liver triglyceride; the ratio of liver to body weight; accumulation of epididymal, perirenal, and mesenteric fat; the degree of hepatic steatosis; and adipocyte hypertrophy, with the concomitant reduction of body weight. Moreover, HT decreased the expression levels of proinfiammatory cytokines tumor necrosis factor a (TNF alpha), inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2) and reduced fatty acid synthase (FAS) activity in liver tissue of obese mice. In addition, HT treatment also increased the phosphorylation of AMP-activated protein kinase (AMPK) and its direct downstream proteins, acetyl coenzyme A carboxylase (ACC), and carnitine palmitoyltransferase I (CPT-1), which participate in FAS pathway.
   Conclusions: These findings demonstrate that HT treatment has a potential protection on high-fat diet-induced obesity mice via activating the AMPIUACC/CPT1 pathway, and to a certain extent, it has nothing to do with the storage time of three kinds of HT.
C1 [Li, Qiuhua; Lai, Xingfei; Sun, Lingli; Cao, Junxi; Ling, Caijin; Zhang, Wenji; Xiang, Limin; Chen, Ruohong; Sun, Shili] Guangdong Acad Agr Sci, Tea Res Inst, Guangdong Prov Key Lab Tea Plant Resources Innova, Guangzhou, Peoples R China.
   [Li, Dongli] Wuyi Univ, Sch Biotechnol & Hlth Sci, Jiangmen 529020, Peoples R China.
C3 Guangdong Academy of Agricultural Sciences; Wuyi University
RP Li, DL (corresponding author), Wuyi Univ, Sch Biotechnol & Hlth Sci, Jiangmen 529020, Peoples R China.; Sun, SL (corresponding author), Guangdong Acad Agr Sci, Tea Res Inst, Guangzhou 510640, Peoples R China.
EM wyuchemldl@126.com; sunshili@zju.edu.cn
RI Li, Haoyu/ACR-0968-2022; Xiang, Limin/B-9206-2015; lai,
   xingfei/IYJ-6251-2023
OI Xingfei, Lai/0000-0003-3736-605X
FU National Natural Science Foundation of China [81803236, 31800295,
   81903319]; Guangdong Science and Technology program [2017A070702004,
   2016B090918118, 2017A020224015, 2018KJYZ002]; Natural Science Foundation
   of Guangdong Province [2017A030310504]; Guangdong Provincial Agriculture
   Department program [2017LM2151]; President Foundation of Guangdong
   Academy of Agricultural Sciences [201534, 201720]; Science and
   Technology Board of Yingde [JHXM2018029]; Department of Science and
   Technology of Jiangmen [2016350100170008351, 2018110100330005446];
   Foundation from Department of Education of Guangdong Province
   [2016KCXTD005, 2017KSYS010]; Youth Foundation of Wuyi University
   [2017td01]; Special fund for scientific innovation strategy-construction
   of high level Academy of Agriculture Science [R2019PY-JX004,
   R2018YJ-YB3002, R2016YJ-YB3003, R2018PY-QF005, R2018QD-101]
FX No potential conflict of interest was reported by the authors. This work
   was supported by the National Natural Science Foundation of China (Nos.
   81803236, 31800295, 81903319), Guangdong Science and Technology program
   (Nos. 2017A070702004, 2016B090918118, 2017A020224015, 2018KJYZ002),
   Natural Science Foundation of Guangdong Province (No. 2017A030310504),
   the Guangdong Provincial Agriculture Department program (No.
   2017LM2151), the President Foundation of Guangdong Academy of
   Agricultural Sciences (Nos. 201534 and 201720), Science and Technology
   Board of Yingde (No. JHXM2018029), Department of Science and Technology
   of Jiangmen (Nos. 2016350100170008351, 2018110100330005446), and
   Foundation from Department of Education of Guangdong Province (Nos.
   2016KCXTD005, 2017KSYS010), Youth Foundation of Wuyi University (No.
   2017td01), Special fund for scientific innovation strategy-construction
   of high level Academy of Agriculture Science (R2019PY-JX004,
   R2018YJ-YB3002, R2016YJ-YB3003, R2018PY-QF005, R2018QD-101).
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   Yang XQ, 2019, S CHINA AGR, V13, P22, DOI [10.19415/j.cnki.1673-890x.2019.28.006, DOI 10.19415/J.CNKI.1673-890X.2019.28.006]
   Yi GC, 2019, FUJIAN TEA, V41, P7
NR 58
TC 18
Z9 18
U1 4
U2 37
PU SWEDISH NUTRITION FOUNDATION-SNF
PI LUND
PA IDEON SCIENCE PARK, BESOK SCHEELEV 17 BETA 5, 3V, LUND, 223 70, SWEDEN
SN 1654-6628
EI 1654-661X
J9 FOOD NUTR RES
JI Food Nutr. Res.
PD JUN 8
PY 2020
VL 64
AR 1681
DI 10.29219/fnr.v64.1681
PG 13
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA LX2CD
UT WOS:000539644400001
PM 32577118
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Carruthers, M
AF Carruthers, Malcolm
TI Time for international action on treating testosterone deficiency
   syndrome
SO AGING MALE
LA English
DT Article
DE Expert; opinion; testosterone deficiency syndrome; TDS; treatment;
   prevalence; education
ID LOW SERUM TESTOSTERONE; SYMPTOMATIC ANDROGEN DEFICIENCY; HORMONE-BINDING
   GLOBULIN; LATE-ONSET HYPOGONADISM; OLDER MEN; ERECTILE DYSFUNCTION;
   REPLACEMENT THERAPY; ALZHEIMERS-DISEASE; INSULIN-RESISTANCE; METABOLIC
   SYNDROME
AB Aim. Testosterone deficiency is having an increasing impact on men's health because of global aging, higher levels of obesity, diabetes and metabolic syndrome and adverse environmental factors such as stress xenoestrogens and anti-androgens. The question addressed is to what extent the large body of evidence on the benefits and safety of testosterone therapy is applied in clinical practice. Methods. Demographic data for men over the age of 50 from different regions of the world have been compared with the number of men in that age group estimated from sales figures to be receiving testosterone treatment. Results. On the basis of estimate that 20% of men over 50 in the general population of each region could be expected to have testosterone deficiency symptoms, on average only these men (0.69%) in most European countries were receiving treatment. Proportion was higher in the UK (1.00%) and Germany (1.89%), but lower in France (0.49%), Italy (0.51%) and Russia (0.54%). Interestingly, Australia had higher figures (1.64%), in spite of tight state control measures on androgen use. The USA has the highest treatment rate (7.96%) and this is increasing rapidly. If the basis for the diagnosis was the more conventional combination of symptoms plus biochemical evidence of low total and free testosterone levels, androgen deficiency would be expected in at least 5% of men over 50, and percentage treatment rates therefore four times higher. However, even on that basis, only in the USA do these exceed 10%. Conclusions. International action is urgently needed to raise awareness in the medical profession in the various countries of these remarkably low levels of testosterone treatment. Improvement in this requires education and motivation of doctors and those regulating the healthcare systems. A public awareness campaign is needed to educate men about the symptoms of testosterone deficiency and its impact on their health.
C1 Ctr Mens Hlth, London W1G 9PH, England.
RP Carruthers, M (corresponding author), Ctr Mens Hlth, 20-20 Harley St, London W1G 9PH, England.
EM carruthers@centreformenshealth.co.uk
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NR 52
TC 27
Z9 29
U1 0
U2 4
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1368-5538
EI 1473-0790
J9 AGING MALE
JI Aging Male
PY 2009
VL 12
IS 1
BP 21
EP 28
AR PII 909936394
DI 10.1080/13685530802699067
PG 8
WC Endocrinology & Metabolism; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Urology & Nephrology
GA 425ML
UT WOS:000264641700004
PM 19326293
OA Green Published
DA 2025-06-11
ER

PT J
AU Golmohammadi, S
   Tavasolil, M
   Asadi, N
AF Golmohammadi, Sima
   Tavasolil, Marjan
   Asadi, Nadia
TI Prevalence and Risk Factors of Hyperuricemia in Patients with Chronic
   Kidney Disease and Non-Alcoholic Fatty Liver
SO CLINICAL AND EXPERIMENTAL GASTROENTEROLOGY
LA English
DT Article
DE hyperuricemia; serum uric acid; chronic kidney disease; non-alcoholic
   fatty liver disease; Iran
ID DENSITY-LIPOPROTEIN CHOLESTEROL; URIC-ACID; CARDIOVASCULAR-DISEASE;
   ELIMINATION
AB Background/Aims: The number of patients with nonalcoholic fatty liver disease (NAFLD) and chronic kidney disease (CKD) is on the rise. Epidemiological studies have shown the role of hyperuricemia in the development of NAFLD and CKD through oxidative stress and inflammatory mediators. Therefore, this study was conducted to investigate the prevalence and risk factors of hyperuricemia in patients with CKD and NAFLD in Iran.
   Patients and Methods: This study was conducted in 450 CKD patients. NAFLD was diagnosed by ultrasonography. According to the serum uric acid level, all CKD NAFLD patients were divided into non-hyperuricemia and hyperuricemia groups. The patients' demographic and clinical data such as age, sex, abdominal obesity, metabolic syndrome, diabetes, hypertension, CRP, hepatic steatosis, blood pressure, serum uric acid (UA), lipid and creatinine were collected for analysis.
   Results: A total of 279 cases (62%) were diagnosed with NAFLD. The prevalence rate of NFALD in CKD patients was significantly lower in normal UA level than hyperuricemia (42.7% vs 57.3%) (P=0.039). The prevalence of hyperuricemia was about 57.3% in patients with CKD and NAFLD. Accordingly, 279 CKD patients with NAFLD were enrolled and divided into hyperuricemia (n=160) and non-hyperuricemia groups (n=119). Patients with hyperuricemia showed higher creatinine and lipid levels, and a lower GFR compared to patients with normal uric acid levels (P<0.05). However, no significant difference was observed in age, sex, abdominal obesity, metabolic syndrome, hypertension, type 2 diabetes, CRP, and steatosis between hyperuricemia and non-hyperuricemia groups (P>0.05). Three factors, including type 2 diabetes, hyperlipidemia, and a low GFR, serve as independent risk factors for hyperuricemia (P<0.05).
   Conclusion: The results showed a high prevalence of hyperuricemia in patients with CKD and NAFLD. A more comprehensive strategic management is necessary to address the potential harmful effects of hyperuricemia on the health of CKD+ NAFLD(+) cases.
C1 [Golmohammadi, Sima; Tavasolil, Marjan; Asadi, Nadia] Kermanshah Univ Med Sci, Imam Reza Hosp, Clin Res Dev Ctr, Kermanshah, Iran.
   [Golmohammadi, Sima; Asadi, Nadia] Kermanshah Univ Med Sci, Sch Med, Dept Internal Med, Kermanshah, Iran.
C3 Kermanshah University of Medical Sciences; Kermanshah University of
   Medical Sciences
RP Asadi, N (corresponding author), Kermanshah Univ Med Sci, Imam Reza Hosp, Clin Res Dev Ctr, Kermanshah, Iran.; Asadi, N (corresponding author), Kermanshah Univ Med Sci, Sch Med, Dept Internal Med, Kermanshah, Iran.
EM nadiaasadi597@gmail.com
RI golmohammadi, sima/N-1906-2017
FU Kermanshah University of Medical Sciences, Iran [96362]
FX The authors want to thank their colleagues in Mahdiyeh Clinic of
   Kermanshah, Iran for their contribution to the patient's diagnosis. We
   also extend our thanks to clinical research development center of Imam
   Reza Hospital affiliated to Kermanshah University of Medical Sciences
   for their kind support. This study received financial support from
   Kermanshah University of Medical Sciences, Iran (Grant Number. 96362).
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NR 33
TC 10
Z9 11
U1 3
U2 13
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-7023
J9 CLIN EXP GASTROENTER
JI Clin. Exp. Gastroenterol.
PY 2020
VL 13
BP 299
EP 304
DI 10.2147/CEG.S253619
PG 6
WC Gastroenterology & Hepatology
WE Emerging Sources Citation Index (ESCI)
SC Gastroenterology & Hepatology
GA NF1QW
UT WOS:000563077800001
PM 32903892
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Zhou, J
   Li, G
   Wang, ZH
   Wang, LP
   Dong, PJ
AF Zhou, Jing
   Li, Gang
   Wang, Zhi-Hua
   Wang, Li-Ping
   Dong, Pu-Jiang
TI Effects of low-dose hydroxychloroquine on expression of phosphorylated
   Akt and p53 proteins and cardiomyocyte apoptosis in peri-infarct
   myocardium in rats
SO EXPERIMENTAL & CLINICAL CARDIOLOGY
LA English
DT Article
DE Akt (protein kinase B); Cardiomyocyte apoptosis; Hydroxychloroquine
   (HCQ); Myocardial infarction (MI); P53 (protein 53)
ID TELANGIECTASIA MUTATED KINASE; ATAXIA-TELANGIECTASIA; METABOLIC
   SYNDROME; MYOCYTE APOPTOSIS; ATM; HEART; INFARCTION; INSULIN; DISEASE;
   STRESS
AB BACKGROUND: Low-dose hydroxychloroquine (HCQ) and ataxia-telangiectasia-mutated (ATM) protein kinase have recently been postulated to be beneficial for the prevention of the age-associated metabolic syndrome including hypertension, hypercholesterolemia and glucose intolerance; however, the effects of low-dose HCQ on the expression of ATM downstream phosphorylated Akt (protein kinase B) and p53 proteins and cardiomyocyte apoptosis in the peri-infarct myocardium remain unclear.
   OBJECTIVE: To explore the effects of low-dose HCQ on the expression of phosphorylated Akt and p53 proteins and cardiomyocyte apoptosis in the peri-infarct myocardium in a rat model.
   METHODS: Myocardial infarction (MI) was induced experimentally in a subset of rats, while others underwent sham operation (sham). Three days after operation, surviving Sprague-Dawley male rats were divided into MI+HCQ, MI, sham+HCQ and sham groups. MI+HCQ and sham + HCQ groups were treated with HCQ (3.4 mg/kg); and MI and sham groups were treated with phosphate buffered (ie, physiological) saline (10 mL/kg) by gavage every day for 12 weeks. The expression of phosphorylated Akt and p53 proteins and cardiomyocyte apoptosis in the peri-infarct myocardium was detected by Western blot and terminal deoxynucleotidyl transferase dUTP nick end labelling, respectively.
   RESULTS: Twelve weeks after treatment, the expression of phosphorylated Akt protein was significantly increased (P<0.05). Expression of phosphorylated p53 protein was not significantly different (P>0.05) in the peri-infarct myocardium of the MI+HCQ group from that in the MI group. The cardiomyocyte apoptosis rate in the peri-infarct myocardium was significantly decreased in the MI+HCQ group compared with the MI group (P<0.05).
   CONCLUSION: Low-dose HCQ can significantly increase the expression of phosphorylated Akt protein without significantly impacting expression of phosphorylated p53 protein in the peri-infarct myocardium. Accordingly, it can inhibit cardiomyocyte apoptosis in the peri-infarct myocardium.
C1 [Zhou, Jing; Li, Gang; Wang, Li-Ping] Chongqing Med Univ, Div Cardiol, Dept Geriatr, Affiliated Hosp 1, Chongqing 400016, Peoples R China.
   [Zhou, Jing; Wang, Li-Ping; Dong, Pu-Jiang] Chongqing Med Univ, Lab Res Ctr, Affiliated Hosp 1, Chongqing 400016, Peoples R China.
   [Wang, Zhi-Hua] Chongqing Med Univ, Dept Echocardiog, Affiliated Hosp 1, Chongqing 400016, Peoples R China.
C3 Chongqing Medical University; Chongqing Medical University; Chongqing
   Medical University
RP Li, G (corresponding author), Chongqing Med Univ, Div Cardiol, Dept Geriatr, Affiliated Hosp 1, 1 Yixueyuan Rd, Chongqing 400016, Peoples R China.
EM ganglicqmu@126.com
RI Li, Gang/G-1824-2011; Wang, Liping/B-2827-2012; Zhihua,
   Wang/AFO-5263-2022
FU Natural Science Research Fund of the Chongqing Science & Technology
   Commission in Chongqing City, China (CSTC) [2007BB5276]; Medical Science
   & Technology Research Fund of Health Bureau of Chongqing City, China
   [04-2-154, 2009-2-290]
FX This study was supported by the Natural Science Research Fund of the
   Chongqing Science & Technology Commission in Chongqing City, China
   (CSTC, No. 2007BB5276), and the Medical Science & Technology Research
   Fund of Health Bureau of Chongqing City, China (No. 04-2-154 and No.
   2009-2-290).
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NR 19
TC 6
Z9 6
U1 0
U2 0
PU PULSUS GROUP INC
PI OAKVILLE
PA 2902 S SHERIDAN WAY, OAKVILLE, ONTARIO L6J 7L6, CANADA
SN 1205-6626
J9 EXP CLIN CARDIOL
JI Exp. Clin. Cardiol.
PD SUM
PY 2013
VL 18
IS 2
BP E95
EP E98
PG 4
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 191UU
UT WOS:000322439400006
PM 23940455
DA 2025-06-11
ER

PT J
AU Ozveren, O
   Dogdu, O
   Sengul, C
   Cinar, V
   Eroglu, E
   Kucukdurmaz, Z
   Degertekin, M
AF Ozveren, Olcay
   Dogdu, Orhan
   Sengul, Cihan
   Cinar, Veysel
   Eroglu, Elif
   Kucukdurmaz, Zekeriya
   Degertekin, Muzaffer
TI Deterioration of Heart Rate Recovery Index in Patients with
   Non-Alcoholic Fatty Liver Disease (NAFLD)
SO MEDICAL SCIENCE MONITOR
LA English
DT Article
DE Autonomic Nervous System; Fatty Liver; Heart Rate
ID SYSTEMIC-LUPUS-ERYTHEMATOSUS; METABOLIC-SYNDROME; RATE-VARIABILITY;
   EXERCISE; PREDICTOR; DYSFUNCTION; PREVALENCE; VALIDATION; MORTALITY;
   SEVERITY
AB Background: Non-alcoholic fatty liver disease (NAFLD) has been considered as a benign disease often associated with central obesity and insulin resistance and, in general, with factors of the metabolic syndrome. Heart rate recovery after exercise is a function of vagal reactivation, and its impairment is an independent prognostic indicator for cardiovascular and all-cause mortality. The aim of our study was to evaluate the heart rate recovery index in patients with NAFLD.
   Material/Methods: The study population included 59 patients with NAFLD (mean age=42.3 +/- 9.3 years) and 22 healthy subjects as controls (mean age=40.7 +/- 6.5 years). Basal electrocardiography, echocardiography, and treadmill exercise testing were performed on all patients and controls. The heart rate recovery index was defined as the reduction in the heart rate from the rate at peak exercise to the rate at the 1st minute (HRR1), 2nd minute (HRR2), 3rd minute (HRR3), and 5th minute (HRR5) after stopping exercise stress testing.
   Results: There were significant differences in HRR1 and HRR2 indices between patients with ED and the control group (19.9 +/- 8.2 vs. 34.1 +/- 9.6; p<0.001 and 24.3 +/- 5.4 vs. 40.5 +/- 9.1; p=0.006, respectively). Similarly, HRR indices after the 3rd and 5th minutes of the recovery period were significantly lower in patients with NAFLD compared with those indices in the control group (32.3 +/- 8.5 vs. 58.4 +/- 6.5; p=0.001 and 58 +/- 18.2 vs. 75.1 +/- 15.8; p<0.001). Effort capacity was markedly lower (11 +/- 1.9 vs. 12.5 +/- 1.5 METs; p=0.001) among the patients with NAFLD.
   Conclusions: The heart rate recovery index is deteriorated in patients with NAFLD. When the prognostic significance of the heart rate recovery index is considered, these results may help explain the increased occurrence of cardiac death. It points to the importance of the heart rate recovery index in the identification of high-risk patients.
C1 [Ozveren, Olcay; Cinar, Veysel; Eroglu, Elif; Kucukdurmaz, Zekeriya; Degertekin, Muzaffer] Yeditepe Univ, Sch Med, Dept Cardiol, Istanbul, Turkey.
   [Dogdu, Orhan] Firat Univ, Sch Med, Dept Cardiol, TR-23169 Elazig, Turkey.
   [Sengul, Cihan] Kosuyolu Educ & Training Hosp, Dept Cardiol, Istanbul, Turkey.
C3 Yeditepe University; Firat University
RP Ozveren, O (corresponding author), Yeditepe Univ, Sch Med, Dept Cardiol, Istanbul, Turkey.
EM olcay.ozveren@yeditepe.edu.tr
RI Eroglu, Elif/T-7450-2017
CR Angulo P, 2002, NEW ENGL J MED, V346, P1221, DOI 10.1038/nrdp.2015.80
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NR 27
TC 0
Z9 0
U1 0
U2 2
PU INT SCIENTIFIC LITERATURE, INC
PI SMITHTOWN
PA 361 FOREST LANE, SMITHTOWN, NY 11787 USA
SN 1643-3750
J9 MED SCI MONITOR
JI Med. Sci. Monitor
PD AUG 29
PY 2014
VL 20
PG 5
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA AO0OS
UT WOS:000341010400001
DA 2025-06-11
ER

PT J
AU Morton, NM
   Holmes, MC
   Fiévet, C
   Staels, B
   Tailleux, A
   Mullins, JJ
   Seckl, JR
AF Morton, NM
   Holmes, MC
   Fiévet, C
   Staels, B
   Tailleux, A
   Mullins, JJ
   Seckl, JR
TI Improved lipid and lipoprotein profile, hepatic insulin sensitivity, and
   glucose tolerance in 11β-hydroxysteroid dehydrogenase type 1 null mice.
SO JOURNAL OF BIOLOGICAL CHEMISTRY
LA English
DT Article
ID ACTIVATED RECEPTOR-ALPHA; LIPOGENIC ENZYME GENES; FATTY-ACID OXIDATION;
   MESSENGER-RNA LEVELS; TRANSGENIC MICE; PPAR-ALPHA; GLUCOCORTICOID
   RECEPTOR; TISSUE-DISTRIBUTION; METABOLIC SYNDROME; PRIMARY CULTURES
AB Excess tissue glucocorticoid action may underlie the dyslipidemia, insulin resistance, and impaired glucose tolerance of the metabolic syndrome. 11 beta -Hydroxy-steroid dehydrogenase type 1 (11 beta -HSD-1) catalyzes conversion of circulating inert 11-dehydrocorticosterone into active corticosterone, thus amplifying local intracellular glucocorticoid action, particularly in liver. The importance of 11 beta -HSD-1 in glucose homeostasis is suggested by the resistance of 11 beta -HSD-1(-/-) mice to hyperglycemia upon stress or obesity, due to attenuated gluconeogenic responses. The present study further investigates the metabolic consequences of 11 beta -HSD-1 deficiency, focusing on the lipid and lipoprotein profile. Ad lib fed 11 beta -HSD-1(-/-) mice have markedly lower plasma triglyceride levels. This appears to be driven by increased hepatic expression of enzymes of fat catabolism (carnitine palmitoyltransferase-I, acyl-CoA oxidase, and uncoupling protein-2) and their coordinating transcription factor, peroxisome proliferator-activated receptor-a (PPAR alpha). 11 beta -HSD-1(-/-) mice also have increased HDL cholesterol, with elevated liver mRNA and serum levels of apolipoprotein Al. Conversely, liver A alpha -fibrinogen mRNA levels are decreased. Upon fasting, the normal elevation of peroxisome proliferator-activated receptor-a mRNA is lost in 11 beta -HSD-1(-/-) mice, consistent with attenuated glucocorticoid induction. Despite this, crucial oxidative responses to fasting are maintained; carnitine palmitoyltransferase-I induction and glucose levels are similar to wild type. Refeeding shows exaggerated induction of genes encoding lipogenic enzymes and a more marked suppression of genes for fat catabolism in 11 beta -HSD-1(-/-) mice, implying increased liver insulin sensitivity. Concordant with this, 24-h refed 11 beta -HSD-1(-/-) mice have higher triglyceride but lower glucose levels. Further, 11 beta -HSD-1(-/-) mice have improved glucose tolerance. These data suggest that 11 beta -HSD-1 deficiency produces an improved lipid profile, hepatic insulin sensitization, and a potentially atheroprotective phenotype.
C1 Univ Edinburgh, Western Gen Hosp, Dept Clin Neurosci, Mol Med Ctr, Edinburgh EH4 2XU, Midlothian, Scotland.
   Univ Edinburgh, Mol Physiol Lab, Edinburgh EH8 9AG, Midlothian, Scotland.
   Inst Pasteur, Dept Atherosclerose, U545, INSERM, F-59019 Lille, France.
   Univ Lille 2, F-59019 Lille, France.
C3 University of Edinburgh; University of Edinburgh; Institut National de
   la Sante et de la Recherche Medicale (Inserm); Pasteur Network;
   Universite de Lille; Institut Pasteur Lille; Universite de Lille
RP Univ Edinburgh, Western Gen Hosp, Dept Clin Neurosci, Mol Med Ctr, Crewe Rd S, Edinburgh EH4 2XU, Midlothian, Scotland.
EM nik.morton@ed.ac.uk
RI Seckl, Jonathan/C-3555-2013; Morton, NICHOLAS/ABF-3774-2020; TAILLEUX,
   Anne/R-5530-2018; Staels, Bart/N-9497-2016
OI TAILLEUX, Anne/0000-0003-1430-2627; Staels, Bart/0000-0002-3784-1503
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NR 63
TC 380
Z9 452
U1 0
U2 23
PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3996 USA
SN 0021-9258
EI 1083-351X
J9 J BIOL CHEM
JI J. Biol. Chem.
PD NOV 2
PY 2001
VL 276
IS 44
BP 41293
EP 41300
DI 10.1074/jbc.M103676200
PG 8
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 488FM
UT WOS:000171925600122
PM 11546766
OA hybrid
DA 2025-06-11
ER

PT J
AU Shi, MY
   Han, SY
   Klier, K
   Fobo, G
   Montrone, C
   Yu, SX
   Harada, M
   Henning, AK
   Friedrich, N
   Bahls, M
   Dörr, M
   Nauck, M
   Völzke, H
   Homuth, G
   Grabe, HJ
   Prehn, C
   Adamski, J
   Suhre, K
   Rathmann, W
   Ruepp, A
   Hertel, J
   Peters, A
   Wang-Sattler, R
AF Shi, Mengya
   Han, Siyu
   Klier, Kristin
   Fobo, Gisela
   Montrone, Corinna
   Yu, Shixiang
   Harada, Makoto
   Henning, Ann-Kristin
   Friedrich, Nele
   Bahls, Martin
   Doerr, Marcus
   Nauck, Matthias
   Voelzke, Henry
   Homuth, Georg
   Grabe, Hans J.
   Prehn, Cornelia
   Adamski, Jerzy
   Suhre, Karsten
   Rathmann, Wolfgang
   Ruepp, Andreas
   Hertel, Johannes
   Peters, Annette
   Wang-Sattler, Rui
TI Identification of candidate metabolite biomarkers for metabolic syndrome
   and its five components in population-based human cohorts
SO CARDIOVASCULAR DIABETOLOGY
LA English
DT Article
DE Metabolic syndrome; Obesity; Cardiovascular disease; Hypertension;
   Hyperglycemia; Metabolomics; Amino acids; BCAAs; Phosphatidylcholines;
   Lysophosphatidylcholines
ID INSULIN-RESISTANCE; OXIDATIVE STRESS; OBESITY; INDIVIDUALS; GLUTATHIONE;
   DISEASE; PROFILE; HEALTH; SERINE; ACIDS
AB BackgroundMetabolic Syndrome (MetS) is characterized by risk factors such as abdominal obesity, hypertriglyceridemia, low high-density lipoprotein cholesterol (HDL-C), hypertension, and hyperglycemia, which contribute to the development of cardiovascular disease and type 2 diabetes. Here, we aim to identify candidate metabolite biomarkers of MetS and its associated risk factors to better understand the complex interplay of underlying signaling pathways.MethodsWe quantified serum samples of the KORA F4 study participants (N = 2815) and analyzed 121 metabolites. Multiple regression models adjusted for clinical and lifestyle covariates were used to identify metabolites that were Bonferroni significantly associated with MetS. These findings were replicated in the SHIP-TREND-0 study (N = 988) and further analyzed for the association of replicated metabolites with the five components of MetS. Database-driven networks of the identified metabolites and their interacting enzymes were also constructed.ResultsWe identified and replicated 56 MetS-specific metabolites: 13 were positively associated (e.g., Val, Leu/Ile, Phe, and Tyr), and 43 were negatively associated (e.g., Gly, Ser, and 40 lipids). Moreover, the majority (89%) and minority (23%) of MetS-specific metabolites were associated with low HDL-C and hypertension, respectively. One lipid, lysoPC a C18:2, was negatively associated with MetS and all of its five components, indicating that individuals with MetS and each of the risk factors had lower concentrations of lysoPC a C18:2 compared to corresponding controls. Our metabolic networks elucidated these observations by revealing impaired catabolism of branched-chain and aromatic amino acids, as well as accelerated Gly catabolism.ConclusionOur identified candidate metabolite biomarkers are associated with the pathophysiology of MetS and its risk factors. They could facilitate the development of therapeutic strategies to prevent type 2 diabetes and cardiovascular disease. For instance, elevated levels of lysoPC a C18:2 may protect MetS and its five risk components. More in-depth studies are necessary to determine the mechanism of key metabolites in the MetS pathophysiology.
C1 [Shi, Mengya; Han, Siyu; Yu, Shixiang] Tech Univ Munich TUM, Sch Med, Munich, Germany.
   [Shi, Mengya; Han, Siyu; Yu, Shixiang; Harada, Makoto; Wang-Sattler, Rui] German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Inst Translat Genom, Neuherberg, Germany.
   [Shi, Mengya; Han, Siyu; Harada, Makoto; Peters, Annette; Wang-Sattler, Rui] German Ctr Diabet Res DZD, Partner Neuherberg, Neuherberg, Germany.
   [Klier, Kristin; Grabe, Hans J.; Hertel, Johannes] Univ Med Greifswald, Dept Psychiat & Psychotherapy, Greifswald, Germany.
   [Fobo, Gisela; Montrone, Corinna; Adamski, Jerzy; Ruepp, Andreas] German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Inst Expt Genet, Neuherberg, Germany.
   [Henning, Ann-Kristin; Friedrich, Nele; Nauck, Matthias] Univ Med Greifswald, Inst Clin Chem & Lab Med, Greifswald, Germany.
   [Friedrich, Nele; Bahls, Martin; Doerr, Marcus; Nauck, Matthias; Voelzke, Henry; Hertel, Johannes] German Ctr Cardiovasc Res DZHK, Partner Site Greifswald, Greifswald, Germany.
   [Bahls, Martin; Doerr, Marcus] Univ Med Greifswald, Dept Internal Med B, Greifswald, Germany.
   [Voelzke, Henry] Univ Med Greifswald, Inst Community Med, Greifswald, Germany.
   [Voelzke, Henry] German Ctr Diabet Res DZD, Partner Greifswald, Neuherberg, Germany.
   [Homuth, Georg] Univ Med Greifswald, Interfac Inst Genet & Funct Genom, Greifswald, Germany.
   [Prehn, Cornelia] German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Metabol & Prote Core, Neuherberg, Germany.
   [Adamski, Jerzy] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Biochem, Singapore, Singapore.
   [Adamski, Jerzy] Univ Ljubljana, Inst Biochem, Fac Med, Ljubljana, Slovenia.
   [Suhre, Karsten] Educ City Qatar Fdn, Dept Physiol & Biophys, Weill Cornell Med Qatar, Doha, Qatar.
   [Rathmann, Wolfgang] German Ctr Diabet Res DZD, Partner Dusseldorf, Neuherberg, Germany.
   [Rathmann, Wolfgang] Univ Dusseldorf, Inst Biometr & Epidemiol, German Diabet Ctr, Leibniz Ctr Diabet Res Heinrich Heine, Dusseldorf, Germany.
   [Grabe, Hans J.] German Ctr Neurodegenerat Dis DZNE, Greifswald, Germany.
   [Peters, Annette] German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Inst Epidemiol, Neuherberg, Germany.
   [Peters, Annette; Wang-Sattler, Rui] Ludwig Maximilian Univ Munich LMU, Inst Med Informat Proc Biometry & Epidemiol, Pettenkofer Sch Publ Hlth, Munich, Germany.
   [Peters, Annette] German Ctr Cardiovasc Hlth DZHK EV, Munich Heart Alliance, Partner Site Munich, Munich, Germany.
C3 Technical University of Munich; Helmholtz Association; Helmholtz-Center
   Munich - German Research Center for Environmental Health; German Center
   for Diabetes Research (DZD); Universitat Greifswald; Greifswald Medical
   School; Helmholtz Association; Helmholtz-Center Munich - German Research
   Center for Environmental Health; Universitat Greifswald; Greifswald
   Medical School; German Centre for Cardiovascular Research; Universitat
   Greifswald; Greifswald Medical School; Universitat Greifswald;
   Greifswald Medical School; German Center for Diabetes Research (DZD);
   Universitat Greifswald; Greifswald Medical School; Helmholtz
   Association; Helmholtz-Center Munich - German Research Center for
   Environmental Health; National University of Singapore; University of
   Ljubljana; Qatar Foundation (QF); Weill Cornell Medical College Qatar;
   German Center for Diabetes Research (DZD); Heinrich Heine University
   Dusseldorf; Leibniz Association; Deutsches Diabetes-Zentrum (DDZ);
   Helmholtz Association; German Center for Neurodegenerative Diseases
   (DZNE); Helmholtz Association; Helmholtz-Center Munich - German Research
   Center for Environmental Health; University of Munich; Munich Heart
   Alliance
RP Wang-Sattler, R (corresponding author), German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Inst Translat Genom, Neuherberg, Germany.; Wang-Sattler, R (corresponding author), German Ctr Diabet Res DZD, Partner Neuherberg, Neuherberg, Germany.; Wang-Sattler, R (corresponding author), Ludwig Maximilian Univ Munich LMU, Inst Med Informat Proc Biometry & Epidemiol, Pettenkofer Sch Publ Hlth, Munich, Germany.
EM rui.wang-sattler@helmholtz-munich.de
RI Peters, Annette/A-6117-2011; Harada, Makoto/AFM-7844-2022; Suhre,
   Karsten/AAF-1778-2020; Hertel, Johannes/HZJ-3685-2023; Qasrawi,
   Radwan/AAA-6245-2019; Bahls, Martin/Q-6639-2018; Wang-Sattler,
   Rui/B-5354-2014
OI Prehn, Cornelia/0000-0002-1274-4715; Bahls, Martin/0000-0002-2016-5852;
   Wang-Sattler, Rui/0000-0002-8794-8229; Klier,
   Kristin/0009-0003-3098-5867; Harada, Makoto/0000-0002-6209-7683
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NR 67
TC 21
Z9 21
U1 0
U2 7
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1475-2840
J9 CARDIOVASC DIABETOL
JI Cardiovasc. Diabetol.
PD JUN 16
PY 2023
VL 22
IS 1
AR 141
DI 10.1186/s12933-023-01862-z
PG 16
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism
GA J1AC7
UT WOS:001006991600002
PM 37328862
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Yaghooti-Khorasani, M
   Ghazizadeh, H
   Bijari, M
   Mohammadi-Bajgiran, M
   Oladi, MR
   Zare-Feizabadi, R
   Timar, A
   Nazarpour, S
   Khedmatgozar, H
   Rohban, M
   Hasanzadeh, E
   Javandoost, A
   Banpoor, H
   Andalibi, MSS
   Moazedi, S
   Mosalman-Zadeh, N
   Aghasizadeh, M
   Ferns, GA
   Esmaily, H
   Ghayour-Mobarhan, M
AF Yaghooti-Khorasani, Mahdiyeh
   Ghazizadeh, Hamideh
   Bijari, Moniba
   Mohammadi-Bajgiran, Maryam
   Oladi, Mohammad Reza
   Zare-Feizabadi, Reza
   Timar, Ameneh
   Nazarpour, Shahin
   Khedmatgozar, Hamed
   Rohban, Mohadeseh
   Hasanzadeh, Elahe
   Javandoost, Ali
   Banpoor, Hamed
   Andalibi, Mohammad Sobhan Sheikh
   Moazedi, Sara
   Mosalman-Zadeh, Negin
   Aghasizadeh, Maliheh
   Ferns, Gordon A.
   Esmaily, Habibollah
   Ghayour-Mobarhan, Majid
TI Evaluation of ABO blood group in subjects with CVD risk factors in a
   population sample from northeastern Iran
SO DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS
LA English
DT Article
DE ABO blood group; Cardiovascular disease; High sensitivity C-reactive
   protein; Anti-heat-shock protein 27; Pro-oxidant-antioxidant balance
ID PROOXIDANT-ANTIOXIDANT BALANCE; C-REACTIVE PROTEIN; ENDOTHELIAL ADHESION
   MOLECULES; OXIDATIVE STRESS; CARDIOVASCULAR-DISEASE; INFLAMMATORY
   MARKERS; METABOLIC SYNDROME; ANTIBODY-TITERS; SELECTIN LEVELS;
   ASSOCIATION
AB Background and aims: The ABO blood group system is a genetic polymorphism which can affect the clearance of von Willebrand factor. We aimed to assess the levels of newer biomarkers of cardiovascular disease (CVD) risk; pro-oxidant-antioxidant balance (PAB), high sensitivity C-reactive protein (hs-CRP) and anti-heat-shock protein27 (anti-Hsp27) antibody titers in subjects with various blood groups (A, B, AB and O) and with or without traditional CVD risk factors.
   Methods: The cross-sectional study comprised 6910 subjects. Antigen-antibody agglutination was evaluated by the slide test method for identification of ABO blood groups.
   Results: Among three markers, only Serum anti-Hsp27 titers significantly differed between the four blood groups and showed the highest and lowest values in AB and O blood groups (0.26 +/- 0.22 and 0.23 +/- 0.18 OD, respectively; P < 0.05). Serum anti-Hsp27 was higher in individuals with an AB blood group with metabolic syndrome (MetS), dyslipidemia, hypertension (HTN) and obesity and it was lower in subjects with O blood group; though, two other biomarkers, serum PAB and hs-CRP, were not significantly different between the ABO blood groups. However, they were not different among blood groups in participants with or without diabetes mellitus (DM) (P > 0.05).
   Conclusion: Individuals with an AB blood group and high levels of anti-Hsp27 antibody titers may be predisposed to CVDs that can be mediated through the traditional CVD risk factors among middle-aged subjects from northeastern Iran. The fact that differences in anti Hsp27 are only found in the subgroup with other risk factors suggest that the difference between ABO blood groups is a consequence rather than a cause. (C) 2020 Diabetes India. Published by Elsevier Ltd. All rights reserved.
C1 [Yaghooti-Khorasani, Mahdiyeh; Bijari, Moniba; Mohammadi-Bajgiran, Maryam; Zare-Feizabadi, Reza; Timar, Ameneh; Nazarpour, Shahin; Khedmatgozar, Hamed; Rohban, Mohadeseh; Hasanzadeh, Elahe; Javandoost, Ali; Banpoor, Hamed; Andalibi, Mohammad Sobhan Sheikh; Ghayour-Mobarhan, Majid] Mashhad Univ Med Sci, Metab Syndrome Res Ctr, Mashhad 9919991766, Razavi Khorasan, Iran.
   [Ghazizadeh, Hamideh] Mashhad Univ Med Sci, Student Res Comm, Mashhad, Razavi Khorasan, Iran.
   [Ghazizadeh, Hamideh; Mohammadi-Bajgiran, Maryam; Oladi, Mohammad Reza; Ghayour-Mobarhan, Majid] Mashhad Univ Med Sci, Int UNESCO Ctr Hlth Related Basic Sci & Human Nut, Mashhad, Razavi Khorasan, Iran.
   [Khedmatgozar, Hamed] Texas Tech Univ, Ctr Biotechnol & Genom, Lubbock, TX 79409 USA.
   [Hasanzadeh, Elahe] Mashhad Univ Med Sci, Fac Med, Mashhad, Razavi Khorasan, Iran.
   [Moazedi, Sara; Mosalman-Zadeh, Negin] Varastegan Inst Med Sci, Dept Nutr Sci, Mashhad, Razavi Khorasan, Iran.
   [Aghasizadeh, Maliheh] Birjand Univ Med Sci, Dept Mol Med, Student Res Comm, Fac Med, Birjand, Iran.
   [Ferns, Gordon A.] Brighton & Sussex Med Sch, Div Med Educ, Brighton, Sussex, England.
   [Esmaily, Habibollah] Mashhad Univ Med Sci, Social Determinants Hlth Res Ctr, Mashhad, Razavi Khorasan, Iran.
   [Ghayour-Mobarhan, Majid] Mashhad Univ Med Sci, Dept Nutr, Fac Med, Mashhad, Razavi Khorasan, Iran.
C3 Mashhad University of Medical Sciences; Mashhad University of Medical
   Sciences; Mashhad University of Medical Sciences; Texas Tech University
   System; Texas Tech University; Mashhad University of Medical Sciences;
   Birjand University of Medical Sciences; University of Sussex; University
   of Brighton; Mashhad University of Medical Sciences; Mashhad University
   of Medical Sciences
RP Ghayour-Mobarhan, M (corresponding author), Mashhad Univ Med Sci, Metab Syndrome Res Ctr, Mashhad 9919991766, Razavi Khorasan, Iran.; Esmaily, H (corresponding author), Mashhad Univ Med Sci, Social Determinants Hlth Res Ctr, Mashhad, Razavi Khorasan, Iran.
EM esmailyh@mums.ac.ir; ghayourm@mums.ac.ir
RI Ghazizadeh, Hamideh/ABE-8941-2020; Ghayour-Mobarhan,
   Majid/AAY-5963-2020; Hasanzadeh, Elahe/AAL-4486-2021; Sheikh Andalibi,
   Mohammadsobhan/N-4411-2015
OI Aghasizadeh, Malihe/0000-0001-8562-360X; Sheikh Andalibi,
   Mohammadsobhan/0000-0002-4895-1214; Yaghooti Khorasani,
   Mahdiyeh/0000-0001-5110-0851; Hasanzadeh, Elahe/0000-0002-4764-9638
FU Mashhad University of Medical Sciences Research Council
FX We would like to thank Mashhad University of Medical Sciences Research
   Council for their financial supports.
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NR 69
TC 3
Z9 3
U1 0
U2 3
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1871-4021
EI 1878-0334
J9 DIAB MET SYND CLIN R
JI DIABET. METAB. SYNDR. CLIN. RES. REV.
PD NOV-DEC
PY 2020
VL 14
IS 6
BP 1689
EP 1695
DI 10.1016/j.dsx.2020.08.031
PG 7
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA PO7TE
UT WOS:000605370300026
PM 32905941
DA 2025-06-11
ER

PT J
AU Abachi, S
   Pilon, G
   Marette, A
   Bazinet, L
   Beaulieu, L
AF Abachi, Soheila
   Pilon, Genevieve
   Marette, Andre
   Bazinet, Laurent
   Beaulieu, Lucie
TI Immunomodulatory effects of fish peptides on cardiometabolic syndrome
   associated risk factors: A review
SO FOOD REVIEWS INTERNATIONAL
LA English
DT Review
DE Biopeptides; diabetes; dyslipidemia; hypertension; inflammation; obesity
ID NF-KAPPA-B; C-REACTIVE PROTEIN; NECROSIS-FACTOR-ALPHA; MARINE
   OLIGOPEPTIDE PREPARATION; INDUCED INFLAMMATORY RESPONSES; SALMON
   ONCORHYNCHUS-KETA; TISSUE OXIDATIVE STRESS; CHAIN AMINO-ACIDS;
   NITRIC-OXIDE; TNF-ALPHA
AB Many types of marine-derived products specifically biopeptides, among other health benefiting properties, such as anti-oxidation, anti-infection, anti-hypertension, can also positively affect the immune system through modulations of its cellular responses hence preventing and/or treating many unhealthy conditions inclusive of the metabolic syndrome and its core risk factors. These bioactivities are not solely defined for specific species and many types of fish, farmed or wild-caught, for example, generally salmon, tilapia, cod, sardine, croaker, and others, exhibit comparable health effects. Immuno-potentiating effects of fish-derived peptides on acute and chronic inflammation as well as its related diseases have repeatedly been documented over recent decades. A vast number of pro- and anti-inflammatory cytokines and chemokines have been the subject of these analyses. However, only handful such as interleukins, prostaglandins, etc. and associated signalling pathways, which could simultaneously play pro- and/or anti-inflammatory roles in the innate and/or adaptive immunity of the host, are commonly tested. In addition to the inflammatory ailments, such as inflammatory bowel syndrome, glomerulonephritis, hepatitis and/or arthritis, many of these cytokines and chemokines are also the cause or the effect of metabolic syndrome and its linked risk factors. To date, numerous reviews on the topics of natural, food, animal, dairy and marine immunoregulatory peptides have been published, yet none explicitly has reviewed fish biopeptides. Therefore, cooperatively this document is prepared with the primary focus on the extraction, isolation and immunomodulating bio-effects of fish extracted peptides on cytokines, which are the crucial elements in development and establishment of metabolic diseases and related risk factors, for example, hypertension, obesity, insulin resistance and others. To extend the knowledge of readers on the topic and its trends, authors will briefly discuss the drug-likeness and the pharmacokinetics, as well as the predicted target proteins of fish immunomodulating peptides.
C1 [Abachi, Soheila; Pilon, Genevieve; Marette, Andre; Bazinet, Laurent; Beaulieu, Lucie] Univ Laval, Inst Nutr & Funct Foods, Quebec City, PQ, Canada.
   [Abachi, Soheila; Bazinet, Laurent; Beaulieu, Lucie] Univ Laval, Fac Agr & Food Sci, Dept Food Sci, Quebec City, PQ, Canada.
   [Pilon, Genevieve; Marette, Andre] Cardiol Axis Quebec Heart & Lung Inst, Fac Med, Dept Med, Quebec City, PQ, Canada.
C3 Laval University; Laval University; Quebec Heart & Lung Institute; Laval
   University
RP Beaulieu, L (corresponding author), Univ Laval, Fac Agr & Food Sci, Dept Food Sci, Quebec City, PQ, Canada.
EM lucie.beaulieu@fsaa.ulaval.ca
RI Marette, Andre/E-9342-2013; Bazinet, Laurent/B-1932-2015; Abachi,
   Soheila/AAC-9643-2022
OI Bazinet, Laurent/0000-0002-6818-3558; Abachi,
   Soheila/0000-0002-9807-3632
FU Natural Sciences and Engineering Research Council of Canada
   [STPGP/479527 -2015]
FX This work was supported by the Natural Sciences and Engineering Research
   Council of Canada [STPGP/479527 -2015].
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NR 188
TC 10
Z9 10
U1 1
U2 24
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 8755-9129
EI 1525-6103
J9 FOOD REV INT
JI Food Rev. Int.
PY 2023
VL 39
IS 7
BP 3926
EP 3969
DI 10.1080/87559129.2021.2014861
EA DEC 2021
PG 44
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA U5IO8
UT WOS:000733990900001
DA 2025-06-11
ER

PT J
AU Kim, T
   Choi, H
   Kang, J
   Kim, J
AF Kim, Taeyun
   Choi, Hyunji
   Kang, Jihun
   Kim, Jehun
TI Association between electronic cigarette use and metabolic syndrome in
   the Korean general population: A nationwide population-based study
SO PLOS ONE
LA English
DT Article
ID OXIDATIVE STRESS; SMOKING; NICOTINE; HEALTH
AB Objectives Although smoking is known to have a negative impact in patients with metabolic syndrome (MetS), only a few studies have examined the association between electronic cigarette (e-cig) use and MetS. Methods Among 22,948 participants in the 6th Korea National Health and Nutrition Examination Survey, 14,738 (13,459 [91.3%] never, 954 [6.5%] ever, and 325 [2.2%] current e-cig users) were selected. The relationship between e-cig exposure and MetS (based on the National Cholesterol Education Program Adult Treatment Panel [NCEP-ATP] III criteria) was evaluated using a multivariable logistic regression analysis. An unweighted analysis was performed to evaluate this association without a sampling weight. A subgroup analysis was performed among active smokers to compare dual users with never e-cig users. Results Among current e-cig users, 85.0% were dual users, 12.7% were former cigarette users, and 2.2% were only e-cig users. After adjustment for covariates, abdominal obesity and hypertriglyceridemia were significantly associated with current e-cig exposure (odds ratio [OR]: 1.88, 95% confidence interval [CI]: 1.41-2.50 and OR: 1.32, 95% CI: 1.00-1.74 respectively [compared with the never e-cig users group]). Compared with never e-cig users, current e-cig users showed an OR of 1.27 (95% CI: 0.96-1.70,P-trend= 0.01) for MetS. In the unweighted analysis, the OR for MetS in current e-cig users was 1.40 (95% CI: 1.08-1.81,P-trend<0.01). Compared with never e-cig users, dual users showed a higher OR for abdominal obesity (OR: 1.71, 95% CI: 1.25-2.34,P-trend<0.001). Conclusions Current e-cig exposure was associated with an increased risk of MetS. Dual use of e-cigs and cigarettes was associated with abdominal obesity. Further longitudinal studies and better assessment of e-cig use and type are needed to clarify this relationship.
C1 [Kim, Taeyun] Armed Forces Goyang Hosp, Dept Internal Med, Div Pulmonol, Goyang Si, South Korea.
   [Choi, Hyunji] Kosin Univ Gospel Hosp, Dept Lab Med, Busan, South Korea.
   [Kang, Jihun] Kosin Univ Gospel Hosp, Dept Family Med, Busan, South Korea.
   [Kim, Jehun] Kosin Univ Gospel Hosp, Dept Internal Med, Div Pulmonol, Busan, South Korea.
RP Kim, T (corresponding author), Armed Forces Goyang Hosp, Dept Internal Med, Div Pulmonol, Goyang Si, South Korea.
EM jimsb89@naver.com
RI Kang, Jihun/Q-9804-2019; Kim, Taeyun/AAL-3477-2021
OI Kim, Taeyun/0000-0001-7786-5051; Choi, Hyunji/0000-0002-6453-7099
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NR 34
TC 14
Z9 15
U1 0
U2 3
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD AUG 21
PY 2020
VL 15
IS 8
AR e0237983
DI 10.1371/journal.pone.0237983
PG 11
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA NG6GN
UT WOS:000564080300015
PM 32822397
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Fernández-Martínez, E
   Lira-Islas, IG
   Cario-Corts, R
   Soria-Jasso, LE
   Pérez-Hernández, E
   Pérez-Hernández, N
AF Fernandez-Martinez, Eduardo
   Lira-Islas, Ivet G.
   Carino-Cortes, Raquel
   Soria-Jasso, Luis E.
   Perez-Hernandez, Elizabeth
   Perez-Hernandez, Nury
TI Dietary chia seeds (Salvia hispanica) improve acute dyslipidemia
   and steatohepatitis in rats
SO JOURNAL OF FOOD BIOCHEMISTRY
LA English
DT Article
DE chia; dyslipidemia; fatty acids; fatty liver; omega-3; steatohepatitis
ID POLYUNSATURATED FATTY-ACIDS; OXIDATIVE STRESS; CARBON-TETRACHLORIDE;
   NONALCOHOLIC STEATOHEPATITIS; NLRP3 INFLAMMASOME; INSULIN-RESISTANCE;
   HEPATIC STEATOSIS; FUNCTIONAL FOODS; PLASMA-LIPIDS; LIVER
AB Chia seeds (Salvia hispanica L.) are rich in omega fatty acids. Dyslipidemia and steatohepatitis are diseases that require effective treatments in obese and non-obese patients. The aim was to evaluate the effect of chia intake on acute tyloxapol (TI)-induced dyslipidemia, on acute carbon tetrachloride (TC)-induced steatohepatitis, and on mixed damage (TC+TI) in non-obese rats. Four experimental groups were fed for 4 weeks a diet with established rodent food (DE), and four groups were fed a diet with 15% added chia (DC). Plasma samples were analyzed for total cholesterol, triglycerides, glucose, biochemical liver damage markers, and tumor necrosis factor-alpha (TNF-alpha). Liver samples were used to quantify glycogen, catalase, lipid peroxidation, and TNF-alpha. A histopathological analysis was performed. DC intake partially or totally prevented steatohepatitis, and reduced lipids in the dyslipidemic groups. The hypolipidemic and hepatoprotective effects of chia may be correlated to its high content of alpha-linolenic acid (omega-3) and phenolics. Practical applications Metabolic syndrome is associated with non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH), which are currently the most common causes of chronic liver disease, cirrhosis, and hepatocellular carcinoma (HCC) worldwide. Dyslipidemia is a significant risk factor for NAFLD and NASH. Non-obese patients may have NAFLD or NASH. Metabolic syndrome and dyslipidemia are more strongly associated with NAFLD in non-obese than in obese patients. This is the first study evaluating the hypolipidemic and hepatoprotective effects of chia seed intake on acute dyslipidemia and/or steatohepatitis caused by the individual or combined administration of the inducers tyloxapol and carbon tetrachloride, respectively, in non-obese rats. The pharmacological effects of dietary chia are correlated to its high content of omega-3 and omega-6 (1:1), protein, dietary fiber, and phenolics. The results suggest that inclusion of chia in diets of non-obese patients with dyslipidemia and/or NAFLD/NASH may improve their health state and preventing cirrhosis or HCC.
C1 [Fernandez-Martinez, Eduardo; Lira-Islas, Ivet G.; Carino-Cortes, Raquel; Soria-Jasso, Luis E.] Univ Autonoma Estado Hidalgo, Inst Ciencias Salud, Area Acad Med, Lab Med Chem & Pharmacol,Ctr Invest Biol Reprod, Pachuca, Mexico.
   [Perez-Hernandez, Elizabeth] IMSS, Hosp Ortopedia Dr Victorio de la Fuente Narvaez, Ciudad De Mexico, Mexico.
   [Perez-Hernandez, Nury] Inst Politecn Nacl, Escuela Nacl Med & Homeopatia, Programa Inst Biomed Mol, Ciudad De Mexico, Mexico.
C3 Universidad Autonoma del Estado de Hidalgo; Instituto Mexicano del
   Seguro Social; Instituto Politecnico Nacional - Mexico
RP Fernández-Martínez, E (corresponding author), Univ Autonoma Estado Hidalgo, Inst Ciencias Salud, Area Acad Med, Lab Med Chem & Pharmacol,Ctr Invest Biol Reprod, Calle Dr Eliseo Ramirez Ulloa 400, Pachuca Hidalgo 42090, Mexico.
EM efernan@uaeh.edu.mx
RI Perez-Hernandez, Nury/G-5315-2019; Fernández-Martínez,
   Eduardo/AAJ-4920-2020; Cariño-Cortes, Raquel/E-5302-2018; Pérez,
   Elizabeth/GQB-0779-2022
OI Fernandez-Martinez, Eduardo/0000-0003-3280-1323; Carino-Cortes,
   Raquel/0000-0003-4776-3534; PEREZ HERNANDEZ,
   ELIZABETH/0000-0001-5834-3960
FU Universidad Autonoma del Estado de Hidalgo [DI-ICSA-MED-SF-046, 3]
FX Universidad Autonoma del Estado de Hidalgo, Grant/Award Number:
   PAI-UAEH, key DI-ICSA-MED-SF-046, project number 3
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NR 91
TC 38
Z9 40
U1 0
U2 20
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0145-8884
EI 1745-4514
J9 J FOOD BIOCHEM
JI J. Food Biochem.
PD SEP
PY 2019
VL 43
IS 9
AR e12986
DI 10.1111/jfbc.12986
EA JUL 2019
PG 17
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA IY2QK
UT WOS:000477104900001
PM 31489674
OA gold
DA 2025-06-11
ER

PT J
AU Lee, YJ
   Lee, HR
   Lee, JH
   Shin, YH
   Shim, JY
AF Lee, Yong-Jae
   Lee, Hye-Ree
   Lee, Jung-Hyun
   Shin, Youn-Ho
   Shim, Jae-Yong
TI Association between serum uric acid and non-alcoholic fatty liver
   disease in Korean adults
SO CLINICAL CHEMISTRY AND LABORATORY MEDICINE
LA English
DT Article
DE inflammation; insulin resistance; non-alcoholic fatty liver disease;
   uric acid
ID C-REACTIVE PROTEIN; METABOLIC SYNDROME; INSULIN-RESISTANCE;
   RISK-FACTORS; PREVALENCE; HYPERURICEMIA; STEATOSIS; LEVEL; MEN
AB Background: Increased uric acid is associated with the metabolic syndrome, conditions linked to oxidative stress and insulin resistance. Non-alcoholic fatty liver disease (NAFLD) is now considered a hepatic manifestation of insulin resistance. However, little has been written regarding the association between uric acid and NAFLD.
   Methods: We examined the association between uric acid and the presence of NAFLD in 3768 Koreans (2133 men, 1635 women; aged 20-75 years) in a health examination program. Uric acid quartiles were categorized separately as follows: Q1: <= 291.5, Q2: 291.6-333.1, Q3: 333.2-380.7, and Q4: >= 380.8 mu mol/L for men; Q1: <= 202.2, Q2: 202.3-232.0, Q3: 231.1-267.7, and Q4: >= 267.8 mu mol/L for women. Hepatic steatosis was diagnosed based on abdominal ultrasonographic findings by hyperechogenicity of liver tissue, difference of echogenicity between the liver and diaphragm, and visibility of vascular structures. The odds ratios (ORs) and 95% confidence intervals (CIs) for NAFLD were calculated across each quartile of serum uric acid.
   Results: The prevalence of NAFLD was 25.8% (32.2% in men and 17.4% in women). After adjustment for age, body mass index (BMI), smoking, regular exercise, blood pressure, fasting plasma glucose (FPG), triglycerides, and high-density lipoprotein (HDL) cholesterol, the ORs (95% CIs) for NAFLD according to each quartile of uric acid were 1.00, 1.55 (1.13-2.14), 1.77 (1.30-2.41), and 2.01 (1.45-2.78) for men and 1.00, 0.69 (0.40-1.20), 1.12 (0.67-1.88), and 1.94 (1.21-3.13) for women.
   Conclusions: Serum uric acid is independently associated with the presence of NAFLD, and uric acid may be a useful additional measure in assessing the risk of NAFLD in the clinical setting. Clin Chem Lab Med 2010; 48: 175-80.
C1 [Lee, Yong-Jae; Lee, Hye-Ree; Shim, Jae-Yong] Yonsei Univ, Coll Med, Dept Family Med, Seoul 135720, South Korea.
   [Lee, Jung-Hyun] Yonsei Univ, Coll Med, Dept Hlth Promot Ctr, Gangnam Severance Hosp, Seoul 135720, South Korea.
   [Shin, Youn-Ho] CHA Univ, Coll Med, Dept Pediat, Seoul, South Korea.
C3 Yonsei University; Yonsei University Health System; Yonsei University;
   Yonsei University Health System; Pochon Cha University
RP Shim, JY (corresponding author), Yonsei Univ, Coll Med, Dept Family Med, 146-92 Dogok Dong, Seoul 135720, South Korea.
EM hope@yuhs.ac
RI Lee, Yong Jae/GLR-4153-2022; Patthipati, Venkata Suresh/AAT-8233-2021;
   Shim, Jae Yong/GLU-2862-2022
OI Lee, Yong-Jae/0000-0002-6697-476X; Shim, JaeYong/0000-0002-9561-9230
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NR 30
TC 59
Z9 65
U1 0
U2 17
PU WALTER DE GRUYTER GMBH
PI BERLIN
PA GENTHINER STRASSE 13, D-10785 BERLIN, GERMANY
SN 1434-6621
EI 1437-4331
J9 CLIN CHEM LAB MED
JI Clin. Chem. Lab. Med.
PD FEB
PY 2010
VL 48
IS 2
BP 175
EP 180
DI 10.1515/CCLM.2010.037
PG 6
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA 552JM
UT WOS:000274286000004
PM 19961393
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Long, E
   Schwartz, C
   Carlsten, C
AF Long, Erin
   Schwartz, Carley
   Carlsten, Christopher
TI Controlled human exposure to diesel exhaust: a method for understanding
   health effects of traffic-related air pollution
SO PARTICLE AND FIBRE TOXICOLOGY
LA English
DT Review
DE Controlled human exposure; Diesel exhaust; Particulate matter; Air
   pollution; Humans
ID OBSTRUCTIVE PULMONARY-DISEASE; ANTIOXIDANT N-ACETYLCYSTEINE; SHORT-TERM
   EXPOSURE; INFLAMMATORY RESPONSES; METABOLIC SYNDROME; BRONCHIAL
   EPITHELIUM; PERIPHERAL-BLOOD; OXIDATIVE STRESS; LUNG-FUNCTION; ALLERGEN
   COEXPOSURE
AB Diesel exhaust (DE) is a major component of air pollution in urban centers. Controlled human exposure (CHE) experiments are commonly used to investigate the acute effects of DE inhalation specifically and also as a paradigm for investigating responses to traffic-related air pollution (TRAP) more generally. Given the critical role this model plays in our understanding of TRAP's health effects mechanistically and in support of associated policy and regulation, we review the methodology of CHE to DE (CHE-DE) in detail to distill critical elements so that the results of these studies can be understood in context. From 104 eligible publications, we identified 79 CHE-DE studies and extracted information on DE generation, exposure session characteristics, pollutant and particulate composition of exposures, and participant demographics. Virtually all studies had a crossover design, and most studies involved a single DE exposure per participant. Exposure sessions were typically 1 or 2 h in duration, with participants alternating between exercise and rest. Most CHE-DE targeted a PM concentration of 300 mu g/m(3). There was a wide range in commonly measured co-pollutants including nitrogen oxides, carbon monoxide, and total organic compounds. Reporting of detailed parameters of aerosol composition, including particle diameter, was inconsistent between studies, and older studies from a given lab were often cited in lieu of repeating measurements for new experiments. There was a male predominance in participants, and over half of studies involved healthy participants only. Other populations studied include those with asthma, atopy, or metabolic syndrome. Standardization in reporting exposure conditions, potentially using current versions of engines with modern emissions control technology, will allow for more valid comparisons between studies of CHE-DE, while recognizing that diesel engines in much of the world remain old and heterogeneous. Inclusion of female participants as well as populations more susceptible to TRAP will broaden the applicability of results from CHE-DE studies.
C1 [Long, Erin] Univ British Columbia, Fac Med, 317-2194 Hlth Sci Mall, Vancouver, BC V6T 1Z3, Canada.
   [Schwartz, Carley; Carlsten, Christopher] Univ British Columbia, Dept Med, Div Resp Med, 2775 Laurel St 7th Floor, Vancouver, BC V5Z 1M9, Canada.
C3 University of British Columbia; University of British Columbia
RP Carlsten, C (corresponding author), Univ British Columbia, Dept Med, Div Resp Med, 2775 Laurel St 7th Floor, Vancouver, BC V5Z 1M9, Canada.
EM carlsten@mail.ubc.ca
RI Schwartz, Carley/GXG-1642-2022
OI Long, Erin/0000-0002-2556-2689
FU Canada Research Chairs program
FX This project did not receive funding from agencies in the public,
   commercial, or not-for-profit sectors. CC is supported by the Canada
   Research Chairs program.
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NR 147
TC 10
Z9 11
U1 1
U2 26
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1743-8977
J9 PART FIBRE TOXICOL
JI Part. Fibre Toxicol.
PD FEB 25
PY 2022
VL 19
IS 1
AR 15
DI 10.1186/s12989-022-00454-1
PG 22
WC Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Toxicology
GA ZI9PH
UT WOS:000761943500001
PM 35216599
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Chen, C
   Zhou, Q
   Yang, RY
   Wu, Z
   Yuan, HP
   Zhang, N
   Zhi, MC
   Zhang, Y
   Ni, XL
   Wang, ZP
   Gao, DN
   Zhu, XQ
   Cai, JP
   Yang, Z
   Sun, L
AF Chen, Chen
   Zhou, Qi
   Yang, Ruiyue
   Wu, Zhu
   Yuan, Huiping
   Zhang, Nan
   Zhi, Mingchun
   Zhang, Ying
   Ni, Xiaolin
   Wang, Zhaoping
   Gao, Danni
   Zhu, Xiaoquan
   Cai, Jianping
   Yang, Ze
   Sun, Liang
TI Copper exposure association with prevalence of non-alcoholic fatty liver
   disease and insulin resistance among US adults (NHANES 2011-2014)
SO ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
LA English
DT Article
DE Copper; Non-alcoholic fatty liver disease; Sex difference; Insulin
   resistance; National Health and Nutrition Examination; Survey
ID METABOLIC SYNDROME; NATIONAL-HEALTH; HEPATITIS; SERUM; ALCOHOL; GENDER;
   NAFLD; SCORE; GENE
AB Background: Excessive copper (Cu) has risky effect on insulin resistance (IR), oxidative stress and inflammation. Instead, some studies reported serum Cu to be protective for non-alcoholic fatty liver disease (NAFLD). The aim of this study was to reevaluate the evidence for a potential risky correlation of serum Cu to NAFLD in large-scale and non-institutionalized American subjects. Methods: A cross-sectional study of 3211 subjects was from the National Health and Nutrition Examination Survey (NHANES). Logistic regression and cubic spline-based curve-fitting analyses were used to estimate the independent risky effect of Cu to hepatic steatosis index (HSI), US fatty liver index (USFLI) and NAFLD and their dose-effect relationship. Moreover, this association was analyzed in stratification of HOMA-IR, Metabolic syndrome (MetS) and severity of NAFLD, besides age and gender. Results: The average level of serum Cu was 18.67 mu mol/L and the prevalence of NAFLD was 54.53% and 32.60%, respectively defined by HSI and USFLI. Generally, the level of Cu was higher in females than males. Serum Cu was positively associated with higher HSI, USFLI index and risk of NAFLD. In fully adjusted models, compared with the lowest quartile, the risk of NAFLD increased 97% in the highest quartile of Cu. Interestingly, stratified analysis showed that the risky effect of Cu to NAFLD was more prominent in the middle-aged, females and subjects with improved status of IR (lower HOMA-IR and non-Mets) compared with their counterparts. Moreover, we further found that circulating copper was correlated to severity of NAFLD only in males. Conclusion: Excess serum Cu is significantly associated with risk of NAFLD, which is prominent in females, middle-aged and subjects with improved status of IR, and seems to be related to the severity of NAFLD, additionally. It is necessary to be cautious of the toxic effect of Cu and prospective cohort and mechanism studies are needed to verify the causal effect of Cu to NAFLD.
C1 [Chen, Chen; Zhou, Qi; Yang, Ruiyue; Wu, Zhu; Yuan, Huiping; Zhang, Nan; Zhi, Mingchun; Zhang, Ying; Ni, Xiaolin; Wang, Zhaoping; Gao, Danni; Zhu, Xiaoquan; Cai, Jianping; Yang, Ze; Sun, Liang] Natl Hlth Commission, Beijing Hosp, Beijing Inst Geriatr, Natl Ctr Gerontol,Key Lab Geriatr, Beijing, Peoples R China.
   [Chen, Chen; Yang, Ruiyue; Wu, Zhu; Yuan, Huiping; Zhang, Nan; Zhi, Mingchun; Zhang, Ying; Ni, Xiaolin; Wang, Zhaoping; Gao, Danni; Zhu, Xiaoquan; Cai, Jianping; Yang, Ze; Sun, Liang] Chinese Acad Med Sci, Inst Geriatr Med, Beijing, Peoples R China.
   [Sun, Liang] Kunming Med Univ, NHC Key Lab Drug Addict Med, Kunming 650032, Peoples R China.
C3 Beijing Hospital; Chinese Academy of Medical Sciences - Peking Union
   Medical College; Kunming Medical University
RP Sun, L (corresponding author), Natl Hlth Commission, Beijing Hosp, Beijing Inst Geriatr, Natl Ctr Gerontol,Key Lab Geriatr, Beijing, Peoples R China.
EM 17611707809@163.com; zhq201411@163.com; ruiyue_yang@163.com;
   531792978@qq.com; yuanhuiping@126.com; meetzhangnan@163.com;
   zhq201411@163.com; zhangying2016123@163.com; xiaolinni7@126.com;
   zhaoping_wang@yeah.net; gdn0709@163.com; zhuxqyy@163.com;
   caijp61@vip.sina.com; yang_ze@sina.com; sunbmu@foxmail.com
RI Gao, Danni/N-2302-2017; Yang, Ruiyue/HDN-2405-2022
OI Yang, Ruiyue/0000-0002-2304-6728; Zhou, Qi/0000-0001-8961-8015; Xiaolin,
   Ni/0000-0002-9009-1633
FU National Natural Science Foundation of China [91849132, 81870552,
   81872096, 9184910151, 81672075]; CAMS Innovation Fund for Medical
   Sciences [2018-I2M-1-002]; Beijing Hospital Nova Project [BJ-2018-139];
   National Key R&D Program of China [2018YFC2000400]; Priority Union
   Foundation of Yunnan Provincial Science and Technology Department;
   Kunming Medical University [202001AY070001-011]
FX This work was supported by the National Natural Science Foundation of
   China (91849132, 81870552, 81872096, 9184910151 and 81672075), CAMS
   Innovation Fund for Medical Sciences (2018-I2M-1-002), Beijing Hospital
   Nova Project (BJ-2018-139), National Key R&D Program of China
   (2018YFC2000400), Priority Union Foundation of Yunnan Provincial Science
   and Technology Department and Kunming Medical University
   (202001AY070001-011).
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NR 50
TC 44
Z9 45
U1 2
U2 26
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0147-6513
EI 1090-2414
J9 ECOTOX ENVIRON SAFE
JI Ecotox. Environ. Safe.
PD JUL 15
PY 2021
VL 218
AR 112295
DI 10.1016/j.ecoenv.2021.112295
EA MAY 2021
PG 9
WC Environmental Sciences; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Toxicology
GA SU7QR
UT WOS:000663327600007
PM 33962276
OA gold
DA 2025-06-11
ER

PT J
AU Hong, Y
   Choi, SI
   Hong, E
   Kim, GH
AF Hong, YunMin
   Choi, Soo-Im
   Hong, Eunyoung
   Kim, Gun-Hee
TI Psoralea corylifoliaL. extract ameliorates nonalcoholic fatty
   liver disease in free-fatty-acid-incubated HEPG2 cells and in high-fat
   diet-fed mice
SO JOURNAL OF FOOD SCIENCE
LA English
DT Article
DE Nonalcoholic fatty liver disease; metabolic syndrome; obesity; psoralea
   corylifoliaL
ID ALANINE AMINOTRANSFERASE; OXIDATIVE STRESS; NATURAL-HISTORY;
   STEATOHEPATITIS; ANTIOXIDANT; POLYPHENOLS; EXPRESSION; INSULIN;
   ISOBAVACHALCONE; SENSITIVITY
AB Nonalcoholic fatty liver disease (NAFLD) is a common chronic liver disease that is closely related to metabolic syndrome. We investigated the effect of aPsoralea corylifoliaL. (PC) seeds extract (PCE) on NAFLD. PC seeds were extracted using different ethanol concentrations to produce five extracts, and the 70% ethanol PCE, which had the highest phenolic content, was used in subsequentin vitroandin vivoexperiments. The inhibitory effect of PCE on hepatic steatosis was estimated using HepG2 cells treated with oleic acid (OA). In addition, anin vivoNAFLD model was established using high-fat diet (HFD)-induced obese C57BL/6 mice. Obesity was induced in mice over 14 weeks. PCE (100 or 200 mg/kg/day) was administered orally to mice after 8 weeks of the 14-week treatment period for 6 weeks. PCE suppressed lipid accumulation in OA-treated HepG2 cells. PCE ameliorated the antioxidant activity suppressions induced by the HFD. In addition, both PCE100 and PCE200 groups reduced lipid accumulation and the expression levels of inflammatory proteins as compared with HFD group. PCE administration significantly attenuated hepatic steatosis in liver tissues by decreasing the expression of lipogenic protein sterol regulatory element binding protein 1-c (SREBP-1c) and its downstream protein fatty acid synthase (FAS) in HFD-fed mice and in OA-treated HepG2 cells. Furthermore, PCE administration increased the phosphorylation of AMP-activated protein kinase (AMPK) and acetyl-CoA carboxylase. These results suggest that PCE could be used as a functional material to prevent or ameliorate NAFLD by inhibiting lipid accumulation in liver. Practical Application Psoralea corylifoliaL. is rich in polyphenol and other phytochemicals. In this study, we identified the beneficial effects ofPsoralea corylifoliaL. extract on hepatic steatosis in oleic-acid-induced HepG2 cells and high-fat diet-fed mice. The result of this study will provide the evidence that aPsoralea corylifoliaL. extract has potential use as a functional material for the prevention and amelioration of nonalcoholic fatty liver disease.
C1 [Hong, YunMin] Duksung Womens Univ, Dept Hlth Funct Mat, Seoul, South Korea.
   [Choi, Soo-Im] Duksung Womens Univ, Plant Resources Res Inst, Seoul, South Korea.
   [Choi, Soo-Im; Kim, Gun-Hee] Duksung Womens Univ, Dept Food & Nutr, Seoul, South Korea.
   [Hong, Eunyoung] CJ HealthCare, H&B Res & Dev Team, Seoul, South Korea.
C3 Duksung Women's University; Duksung Women's University; Duksung Women's
   University
RP Kim, GH (corresponding author), Duksung Womens Univ, Dept Food & Nutr, Seoul, South Korea.
EM ghkim@duksung.ac.kr
OI Kim, Gun-Hee/0000-0001-8196-7149
FU National Research Foundation of Korea [NRF-2016R1A2B4014740]
FX This study was supported by a grant from the National Research
   Foundation of Korea (NRF-2016R1A2B4014740)
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NR 68
TC 14
Z9 14
U1 0
U2 30
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-1147
EI 1750-3841
J9 J FOOD SCI
JI J. Food Sci.
PD JUL
PY 2020
VL 85
IS 7
BP 2216
EP 2226
DI 10.1111/1750-3841.15166
EA JUN 2020
PG 11
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA ML4LM
UT WOS:000542453400001
PM 32579753
DA 2025-06-11
ER

PT J
AU Mohankumar, SK
   Taylor, CG
   Siemens, L
   Zahradka, P
AF Mohankumar, Suresh K.
   Taylor, Carla G.
   Siemens, Linda
   Zahradka, Peter
TI Acute exposure of L6 myotubes to cis-9, trans-11 and
   trans-10, cis-12 conjugated linoleic acid isomers
   stimulates glucose uptake by modulating
   Ca<SUP>2+</SUP>/calmodulin-dependent protein kinase II
SO INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
LA English
DT Article
DE Glucose uptake; CLA isomers; CaMKII; AMPK; Signal transduction; L6
   myotubes
ID MOUSE SKELETAL-MUSCLE; INSULIN-RESISTANCE; AS160 PHOSPHORYLATION;
   SERUM-LIPIDS; BODY-FAT; TRANSPORT; CAMKII; HEALTH; AMPK; RAT
AB Conjugated linoleic acid (CIA), a dietary fat, has been considered beneficial in metabolic syndrome. Despite several findings indicating that CLA improves glucose clearance, little information is available regarding the cellular dynamics of CLA on skeletal muscle. We sought to investigate the role of Ca2+/calmodulin-dependent protein kinase II (CaMKII) in cis-9, trans-11(c9,t11) and trans-10, cis-12 (t10,c12) CIA isomer-mediated glucose transport by L6 myotubes. t10,c12-CLA stimulated both intracellular Ca2+ release (Ca-i(2+)) and CaMKII phosphorylation, whereas c9,t11-CLA showed only modest effects on both. Sequestering Ca-i(2+) with BAPTA/AM abrogated the effect of both CIA isomers on Akt substrate-160 kDa (AS160) phosphorylation and glucose uptake by myotubes. Exposing myotubes to KN-93 or autocamtide 2-related inhibitory peptide to block CaMKII activity prevented both CLA isomers from inducing AS160 phosphorylation and glucose transport. Likewise, genetic knockdown of CaMKII in myotubes using siRNA completely abolished CLA isomer-mediated glucose uptake. These results indicate that CLA isomers require Cai(2+)-CaMKII to mediate glucose uptake. Evidence that CaMKII blockers inhibit t10,c12-CLA-mediated AMP-activated protein kinase (AMPK) activation indicated that CaMKII acts upstream of AMPK in response to t10,c12-CLA. Lastly, CIA isomers stimulated the formation of reactive oxygen species but had no effect on stress-activated protein kinase/c-jun NH2-terminal kinase. These data establish that t10,c12-CLA acts via Ca-i(2+)-CaMKII-AMPK-AS160 to stimulate skeletal muscle glucose transport, whereas the mechanism of c9,t11-CLA remains unclear. Given that impairments in muscle glucose utilisation are apparent in metabolic syndrome, delineating the molecular mechanisms by which CIA isomers mediate muscle glucose uptake may identify new approaches to manage this condition. (C)0 2012 Elsevier Ltd. All rights reserved.
C1 [Mohankumar, Suresh K.; Taylor, Carla G.; Siemens, Linda; Zahradka, Peter] St Boniface Hosp Res Ctr, Canadian Ctr Agri Food Res Hlth & Med, Winnipeg, MB R2H 2A6, Canada.
   [Mohankumar, Suresh K.; Taylor, Carla G.; Siemens, Linda; Zahradka, Peter] Univ Manitoba, Winnipeg, MB, Canada.
C3 University of Manitoba; Children's Hospital Research Institute of
   Manitoba; Saint Boniface Hospital; University of Manitoba
RP Zahradka, P (corresponding author), St Boniface Hosp Res Ctr, Canadian Ctr Agri Food Res Hlth & Med, 351 Tache Ave, Winnipeg, MB R2H 2A6, Canada.
EM peterz@sbrc.ca
RI Zahradka, Peter/KDM-4700-2024; Mohankumar, Suresh/G-5201-2011
OI Zahradka, Peter/0000-0002-7814-0658; Taylor, Carla
   G./0000-0003-3358-6418; Mohankumar, Suresh/0000-0001-8862-2979
FU Dairy Farmers of Canada; Natural Sciences and Engineering Research
   Council of Canada
FX We thank the St. Boniface General Hospital and Research Foundation (MB,
   Canada) for their generous infrastructure support. This work was funded
   (to CGT and PZ) by the Dairy Farmers of Canada and the Natural Sciences
   and Engineering Research Council of Canada.
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NR 46
TC 14
Z9 15
U1 0
U2 16
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 1357-2725
J9 INT J BIOCHEM CELL B
JI Int. J. Biochem. Cell Biol.
PD AUG
PY 2012
VL 44
IS 8
BP 1321
EP 1330
DI 10.1016/j.biocel.2012.05.005
PG 10
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA 974QE
UT WOS:000306450600015
PM 22609102
DA 2025-06-11
ER

PT J
AU Radonjic, M
   de Haan, JR
   van Erk, MJ
   van Dijk, KW
   van den Berg, SAA
   de Groot, PJ
   Müller, M
   van Ommen, B
AF Radonjic, Marijana
   de Haan, Jorn R.
   van Erk, Marjan J.
   van Dijk, Ko Willems
   van den Berg, Sjoerd A. A.
   de Groot, Philip J.
   Muller, Michael
   van Ommen, Ben
TI Genome-Wide mRNA Expression Analysis of Hepatic Adaptation to High-Fat
   Diets Reveals Switch from an Inflammatory to Steatotic Transcriptional
   Program
SO PLOS ONE
LA English
DT Article
ID NF-KAPPA-B; GENE-EXPRESSION; PPAR-GAMMA;
   15-DEOXY-DELTA(12,14)-PROSTAGLANDIN J(2); APOE-ASTERISK-3LEIDEN MICE;
   INSULIN-RESISTANCE; LIVER STEATOSIS; TRANSGENIC MICE; OBESITY;
   ATHEROSCLEROSIS
AB Background: Excessive exposure to dietary fats is an important factor in the initiation of obesity and metabolic syndrome associated pathologies. The cellular processes associated with the onset and progression of diet-induced metabolic syndrome are insufficiently understood.
   Principal Findings: To identify the mechanisms underlying the pathological changes associated with short and long-term exposure to excess dietary fat, hepatic gene expression of ApoE3Leiden mice fed chow and two types of high-fat (HF) diets was monitored using microarrays during a 16-week period. A functional characterization of 1663 HF-responsive genes reveals perturbations in lipid, cholesterol and oxidative metabolism, immune and inflammatory responses and stress-related pathways. The major changes in gene expression take place during the early (day 3) and late (week 12) phases of HF feeding. This is also associated with characteristic opposite regulation of many HF-affected pathways between these two phases. The most prominent switch occurs in the expression of inflammatory/immune pathways (early activation, late repression) and lipogenic/adipogenic pathways (early repression, late activation). Transcriptional network analysis identifies NF-kappa B, NEMO, Akt, PPARc and SREBP1 as the key controllers of these processes and suggests that direct regulatory interactions between these factors may govern the transition from early (stressed, inflammatory) to late (pathological, steatotic) hepatic adaptation to HF feeding. This transition observed by hepatic gene expression analysis is confirmed by expression of inflammatory proteins in plasma and the late increase in hepatic triglyceride content. In addition, the genes most predictive of fat accumulation in liver during 16-week high-fat feeding period are uncovered by regression analysis of hepatic gene expression and triglyceride levels.
   Conclusions: The transition from an inflammatory to a steatotic transcriptional program, possibly driven by the reciprocal activation of NF-kB and PPARc regulators, emerges as the principal signature of the hepatic adaptation to excess dietary fat. These findings may be of essential interest for devising new strategies aiming to prevent the progression of high-fat diet induced pathologies.
C1 [Radonjic, Marijana; de Haan, Jorn R.; van Erk, Marjan J.; van Dijk, Ko Willems; van den Berg, Sjoerd A. A.; de Groot, Philip J.; Muller, Michael; van Ommen, Ben] Top Inst Food & Nutr, Nutrigenom Consortium, Wageningen, Netherlands.
   [Radonjic, Marijana; de Haan, Jorn R.; van Erk, Marjan J.; van Ommen, Ben] BU Biosci, TNO Qual Life, Zeist, Netherlands.
   [van Dijk, Ko Willems; van den Berg, Sjoerd A. A.] Leiden Univ, Med Ctr, Dept Gen Internal Med, Leiden, Netherlands.
   [van Dijk, Ko Willems; van den Berg, Sjoerd A. A.] Leiden Univ, Med Ctr, Dept Human Genet, Leiden, Netherlands.
   [de Groot, Philip J.; Muller, Michael] Wageningen UR, Dept Human Nutr, Wageningen, Netherlands.
C3 Top Institute Food & Nutrition; Netherlands Organization Applied Science
   Research; Leiden University; Leiden University Medical Center (LUMC);
   Leiden University - Excl LUMC; Leiden University - Excl LUMC; Leiden
   University; Leiden University Medical Center (LUMC); Wageningen
   University & Research
RP Radonjic, M (corresponding author), Top Inst Food & Nutr, Nutrigenom Consortium, Wageningen, Netherlands.
EM marijana.radonjic@tno.nl
RI Muller, Michael/M-5724-2019; van den Berg, Sjoerd/R-9541-2018; Willems
   van Dijk, Ko/A-1798-2008; Muller, Michael/B-5795-2008
OI van den Berg, Sjoerd/0000-0001-8967-376X; van den Berg,
   Sjoerd/0000-0001-5937-7505; Willems van Dijk, Ko/0000-0002-2172-7394;
   Muller, Michael/0000-0002-5930-9905
FU Top Institute Food and Nutrition, The Netherlands [A-006]
FX This work is financially supported by Top Institute Food and Nutrition,
   The Netherlands (Nutrigenomics Consortium, project A-006) and the
   resident institutes of the authors. All authors are member of the
   Nutrigenomics consortium (www.nutrigenomicsconsortium.nl) and European
   Nutrigenomics Organisation (www.nugo.org). The funders had no role in
   study design, data collection and analysis, decision to publish, or
   preparation of the manuscript.
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   MANAGEMENT ANAL DATA
   ARRAYEXPRESS REPOSIT
   NUGO MICROARRAY INFO
NR 81
TC 53
Z9 54
U1 0
U2 3
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD AUG 14
PY 2009
VL 4
IS 8
AR e6646
DI 10.1371/journal.pone.0006646
PG 18
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 483BG
UT WOS:000268936200012
PM 19680557
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Stufano, A
   D'Amore, S
   Schino, V
   Danza, P
   Iavicoli, I
   Lovreglio, P
AF Stufano, Angela
   D'Amore, Simona
   Schino, Valentina
   Danza, Paolo
   Iavicoli, Ivo
   Lovreglio, Piero
TI Metabolic Syndrome and Cardiovascular Risk Factors in a Fishing
   Community in Southern Italy
SO SAFETY AND HEALTH AT WORK
LA English
DT Article
DE Fisheries; Health promotion; Obesity; Total Worker Health (R); Work
   organization
ID HEALTH; PREVALENCE; MORTALITY; FATIGUE; PROFILE; DISEASE; STRESS; COHORT
AB Background: Work organization and psychosocial factors influencing sleep patterns may be significant risk factors for developing obesity and metabolic syndrome (MetS). However, the impact on the health of working patterns in the fishing sector is not well characterized. The aim of the study is to determine the prevalence of MetS and its components in fishermen and to analyze occupational-specific risk factors contributing to metabolic alterations. Methods: One hundred forty-three male fishermen from Apulia (Southern Italy) and 93 male university workers age-matched and from the same geographical area were included in this cross-sectional study. A questionnaire was administered to investigate socio-demographic variables, work activity, health status, and dietary habits. All subjects underwent clinical evaluation and blood sampling to depict their metabolic profile. Results: A higher body mass index (BMI), waist circumference (WC), and waist-to-hip ratio (p < 0.001) were observed in fishermen than in university workers. No significant difference between the two groups was observed in the prevalence of MetS (15.4% fishermen vs 16.1% university workers) and its relevant diagnostic criteria, except abdominal obesity (42.7% fishermen vs 29.0% university workers, p = 0.021). The Castelli risk index, the monocyte/c-HDL ratio, and the Sokolow index were significantly greater in fishermen (p < 0.001). In the fishermen group, the total number of sleeping hours on working days was negatively correlated with WC (r = -0.17; p = 0.04), low-density lipoprotein cholesterol (c-LDL) (r = -0.21; p = 0.02), and the homeostasis model assessment (HOMA) index (r = -0.19; p = 0.02). Conclusion: The higher prevalence of obesity and the imbalance of the metabolic profile observed in fishermen could be related to occupational factors, including the specific working pattern that influences their sleeping hours and sleeping-waking rhythms. (c) 2024 Occupational Safety and Health Research Institute. Published by Elsevier B.V. on behalf of Institute, Occupational Safety and Health Research Institute, Korea Occupational Safety and Health Agency.
C1 [Stufano, Angela; Schino, Valentina; Danza, Paolo; Lovreglio, Piero] Univ Bari, Interdisciplinary Dept Med, Sect Occupat Med, Bari, Italy.
   [D'Amore, Simona] Univ Bari, Dept Precis & Regenerat Med Ionian Pole, Bari, Italy.
   [Iavicoli, Ivo] Univ Naples Federico II, Dept Publ Hlth, Naples, Italy.
C3 Universita degli Studi di Bari Aldo Moro; Universita degli Studi di Bari
   Aldo Moro; University of Naples Federico II
RP Stufano, A (corresponding author), Univ Bari, Giulio Cesare Sq 4, I-70125 Bari, Italy.
EM angela.stufano@uniba.it
RI D'Amore, Simona/H-4431-2018; Mousavi, Seyyed/P-7797-2015
OI D'Amore, Simona/0000-0002-5432-8808
FU Italian Complementary National Plan PNC-I.1 00 Research initiatives for
   innovative technologies [PNC00000 02, CUP: B53C22006420001]
FX We would like to thank all subjects that participated in this study.
   From December 2023 Simona D'Amore position is funded by the Italian
   Complementary National Plan PNC-I.1 00 Research initiatives for
   innovative technologies and pathways in the health and welfare sector"
   D.D. 931 of 06/06/2022, "DARE-DigitAl lifelong pRevEntion" initiative,
   code PNC00000 02, CUP: B53C22006420001.
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NR 43
TC 0
Z9 0
U1 3
U2 3
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2093-7911
EI 2093-7997
J9 SAF HEALTH WORK-KR
JI Saf. Health Work
PD DEC
PY 2024
VL 15
IS 4
BP 464
EP 471
DI 10.1016/j.shaw.2024.10.001
EA DEC 2024
PG 8
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA O8L7E
UT WOS:001373581200001
PM 39697319
OA gold
DA 2025-06-11
ER

PT J
AU Nyakudya, TT
   Tshabalala, T
   Dangarembizi, R
   Erlwanger, KH
   Ndhlala, AR
AF Nyakudya, Trevor T.
   Tshabalala, Thulani
   Dangarembizi, Rachael
   Erlwanger, Kennedy H.
   Ndhlala, Ashwell R.
TI The Potential Therapeutic Value of Medicinal Plants in the Management of
   Metabolic Disorders
SO MOLECULES
LA English
DT Review
DE medicinal plants; metabolic syndrome; diabetes; hypertension; oxidative
   stress; non-alcoholic fatty liver disease
ID POTATO AQUEOUS EXTRACT; OPUNTIA-FICUS-INDICA; STEM BARK EXTRACT;
   DIABETES-MELLITUS; SUTHERLANDIA-FRUTESCENS; CATHARANTHUS-ROSEUS;
   CARDIOVASCULAR-DISEASES; ANTIDIABETIC ACTIVITIES; ETHNOBOTANICAL SURVEY;
   ANTIOXIDANT ACTIVITY
AB Metabolic syndrome (MetS) is a prevalent, multifactorial and complex disease that is associated with an increased risk of developing diabetes and other major cardiovascular complications. The rise in the global prevalence of MetS has been attributed to genetic, epigenetic, and environmental factors. The adoption of sedentary lifestyles that are characterized by low physical activity and the consumption of high-energy diets contributes to MetS development. Current management criteria for MetS risk factors involve changes in lifestyle and the use of pharmacological agents that target specific biochemical pathways involved in the metabolism of nutrients. Pharmaceutical drugs are usually expensive and are associated with several undesirable side effects. Alternative management strategies of MetS risk factors involve the use of medicinal plants that are considered to have multiple therapeutic targets and are easily accessible. Medicinal plants contain several different biologically active compounds that provide health benefits. The impact of phytochemicals present in local medicinal plants on sustainable health and well-being of individuals has been studied for many years and found to involve a plethora of complex biochemical, metabolic, and physiological mechanisms. While some of these phytochemicals are the basis of mainstream prescribed drugs (e.g., metformin, reserpine, quinine, and salicin), there is a need to identify more medicinal plants that can be used for the management of components of MetS and to describe their possible mechanisms of action. In this review, we assess the potential health benefits of South African ethnomedicinal plants in protecting against the development of health outcomes associated with MetS. We aim to provide the state of the current knowledge on the use of medicinal plants and their therapeutically important phytochemicals by discussing the current trends, with critical examples from recent primary references of how medicinal plants are being used in South African rural and urban communities.
C1 [Nyakudya, Trevor T.] Univ Pretoria, Fac Hlth Sci, Sch Med, Dept Physiol, ZA-0002 Pretoria, South Africa.
   [Tshabalala, Thulani] Agr Res Council ARC, Vegetable & Ornamental Plants, Private Bag X923, ZA-0001 Pretoria, South Africa.
   [Tshabalala, Thulani] Univ KwaZulu Natal Pietermaritzburg, Sch Agr Earth & Environm Sci, Private Bag X01, ZA-3209 Scottsville, South Africa.
   [Dangarembizi, Rachael] Univ Cape Town, Fac Hlth Sci, Dept Human Biol, Neurosci Inst,Div Physiol Sci, Anzio Rd, ZA-7925 Cape Town, South Africa.
   [Erlwanger, Kennedy H.] Univ Witwatersrand, Sch Physiol, 7 York Rd, ZA-2193 Parktown, South Africa.
   [Ndhlala, Ashwell R.] Univ Limpopo, Green Technol Res Ctr Excellence, Sch Agr & Environm Sci, Private Bag X1106, ZA-0727 Sovenga, South Africa.
C3 University of Pretoria; University of Kwazulu Natal; University of Cape
   Town; University of Witwatersrand; University of Limpopo
RP Ndhlala, AR (corresponding author), Univ Limpopo, Green Technol Res Ctr Excellence, Sch Agr & Environm Sci, Private Bag X1106, ZA-0727 Sovenga, South Africa.
EM trevor.nyakudya@up.ac.za; TshabalalaT1@arc.agric.za;
   rachael.dangarembizi@uct.ac.za; Kennedy.Erlwanger@wits.ac.za;
   NdhlalaA@arc.agric.za
RI Ndhlala, Ashwell/B-6595-2009; Tshabalala, Thulani/AAI-1556-2020;
   Erlwanger, Kennedy/AAX-2616-2020; Nyakudya, Trevor/ABD-7926-2021;
   Dangarembizi, Rachael/CAF-1749-2022
OI Erlwanger, Kennedy/0000-0001-8058-885X; Nyakudya,
   Trevor/0000-0003-1872-9257; Dangarembizi, Rachael/0000-0003-2211-0625;
   Tshabalala, Thulani/0000-0003-1735-3761
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NR 125
TC 57
Z9 58
U1 0
U2 15
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1420-3049
J9 MOLECULES
JI Molecules
PD JUN
PY 2020
VL 25
IS 11
AR 2669
DI 10.3390/molecules25112669
PG 20
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA MR8RU
UT WOS:000553858800206
PM 32526850
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Butcher, JT
   Goodwill, AG
   Stanley, SC
   Frisbee, JC
AF Butcher, Joshua T.
   Goodwill, Adam G.
   Stanley, Shyla C.
   Frisbee, Jefferson C.
TI Blunted temporal activity of microvascular perfusion heterogeneity in
   metabolic syndrome: a new attractor for peripheral vascular disease?
SO AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
LA English
DT Article
DE rodent models of obesity; microcirculation; skeletal muscle blood flow
   regulation; models of peripheral vascular disease; blood flow
   heterogeneity; vascular dysfunction
ID OBESE ZUCKER RATS; SKELETAL-MUSCLE; BLOOD-FLOW; ANIMAL-MODELS;
   HEMODYNAMICS; ERYTHROCYTES; RESISTANCE; NETWORKS; ARTERIES; ATP
AB Butcher JT, Goodwill AG, Stanley SC, Frisbee JC. Blunted temporal activity of microvascular perfusion heterogeneity in metabolic syndrome: a new attractor for peripheral vascular disease? Am J Physiol Heart Circ Physiol 304: H547-H558, 2013. First published December 21, 2012; doi:10.1152/ajpheart.00805.2012.-A key clinical outcome for peripheral vascular disease (PVD) in patients is a progressive decay in skeletal muscle performance and its ability to resist fatigue with elevated metabolic demand. We have demonstrated that PVD in obese Zucker rats (OZR) is partially due to increased perfusion distribution heterogeneity at successive microvascular bifurcations within skeletal muscle. As this increased heterogeneity (gamma) is longitudinally present in the network, its cumulative impact is a more heterogeneous distribution of perfusion between terminal arterioles than normal, causing greater regional tissue ischemia. To minimize this negative outcome, a likely compensatory mechanism against an increased gamma should be an increased temporal switching at arteriolar bifurcations to minimize downstream perfusion deficits. Using in situ cremaster muscle, we determined that temporal activity (the cumulative sum of absolute differences between successive values of gamma, taken every 20 s) was lower in OZR than in control animals, and this difference was present in both proximal (1A-2A) and distal (3A-4A) arteriolar bifurcations. Although adrenoreceptor blockade (phentolamine) improved temporal activity in 1A-2A arteriolar bifurcations in OZR, this was without impact in the distal microcirculation, where only interventions against oxidant stress (Tempol) and thromboxane A(2) activity (SQ-29548) were effective. Analysis of the attractor for gamma indicated that it was not only elevated in OZR but also exhibited severe reductions in range, suggesting that the ability of the microcirculation to respond to any challenge is highly restricted and may represent the major contributor to the manifestation of poor muscle performance at this age in OZR.
C1 W Virginia Univ, Hlth Sci Ctr, Dept Physiol & Pharmacol, Morgantown, WV 26506 USA.
   W Virginia Univ, Hlth Sci Ctr, Ctr Cardiovasc & Resp Sci, Morgantown, WV 26506 USA.
C3 West Virginia University; West Virginia University
RP Frisbee, JC (corresponding author), W Virginia Univ, Hlth Sci Ctr, Dept Physiol & Pharmacol, Ctr Cardiovasc & Resp Sci, 3152 HSN,1 Med Ctr Dr, Morgantown, WV 26506 USA.
EM jefrisbee@hsc.wvu.edu
RI Butcher, Joshua/ABH-7212-2022; Goodwill, Adam/N-4889-2016
OI Frisbee, Jefferson/0000-0003-2751-0599; Butcher,
   Joshua/0000-0002-7341-1949; Goodwill, Adam/0000-0003-3701-3713
FU Translational Research Facility in the Center for Cardiovascular;
   Respiratory Sciences at the West Virginia University Health Sciences
   Center; National Institutes of Health [NIH DK-R01-64668, T32-HL-90610,
   RR-2865AR]; American Heart Association [AHA EIA 0740129N]
FX We thank Milinda James from the Department of Physiology and
   Pharmacology at West Virginia University for expert technical assistance
   and the Translational Research Facility in the Center for Cardiovascular
   and Respiratory Sciences at the West Virginia University Health Sciences
   Center for support.This study was supported by grants from the National
   Institutes of Health (NIH DK-R01-64668, T32-HL-90610, and RR-2865AR) and
   the American Heart Association (AHA EIA 0740129N).
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NR 59
TC 24
Z9 28
U1 0
U2 10
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0363-6135
EI 1522-1539
J9 AM J PHYSIOL-HEART C
JI Am. J. Physiol.-Heart Circul. Physiol.
PD FEB
PY 2013
VL 304
IS 4
BP H547
EP H558
DI 10.1152/ajpheart.00805.2012
PG 12
WC Cardiac & Cardiovascular Systems; Physiology; Peripheral Vascular
   Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Physiology
GA 092SE
UT WOS:000315141500006
PM 23262133
OA Green Published
DA 2025-06-11
ER

PT J
AU Gómez-Martínez, C
   Babio, N
   Camacho-Barcia, L
   Júlvez, J
   Nishi, SK
   Vázquez, Z
   Forcano, L
   Alvarez-Sala, A
   Cuenca-Royo, A
   de la Torre, R
   Fanlo-Maresma, M
   Tello, S
   Corella, D
   Vásquez, AA
   Dalsgaard, S
   Franke, B
   Fernández-Aranda, F
   Salas-Salvadó, J
AF Gomez-Martinez, Carlos
   Babio, Nancy
   Camacho-Barcia, Lucia
   Julvez, Jordi
   Nishi, Stephanie K.
   Vazquez, Zenaida
   Forcano, Laura
   Alvarez-Sala, Andrea
   Cuenca-Royo, Aida
   de la Torre, Rafael
   Fanlo-Maresma, Marta
   Tello, Susanna
   Corella, Dolores
   Vasquez, Alejandro Arias
   Dalsgaard, Soren
   Franke, Barbara
   Fernandez-Aranda, Fernando
   Salas-Salvado, Jordi
TI Glycated hemoglobin, type 2 diabetes, and poor diabetes control are
   positively associated with impulsivity changes in aged individuals with
   overweight or obesity and metabolic syndrome
SO ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
LA English
DT Article
DE glycated hemoglobin (HbA1c); impulsivity; insulin resistance (HOMA-IR);
   type 2 diabetes control; type 2 diabetes mellitus
ID BLOOD-GLUCOSE; INSULIN-RESISTANCE; OXIDATIVE STRESS; GLYCEMIC CONTROL;
   PERSONALITY; MIDLIFE; ADHERENCE; COGNITION; VALIDITY; RISK
AB Impulsivity has been proposed to have an impact on glycemic dysregulation. However, it remains uncertain whether an unfavorable glycemic status could also contribute to an increase in impulsivity levels. This study aims to analyze associations of baseline and time-varying glycemic status with 3-year time-varying impulsivity in older adults at high risk of cardiovascular disease. A 3-year prospective cohort design was conducted within the PREDIMED-Plus-Cognition substudy. The total population includes 487 participants (mean age = 65.2 years; female = 50.5%) with overweight or obesity and metabolic syndrome. Insulin resistance (HOMA-IR), glycated hemoglobin (HbA1c), presence of type 2 diabetes mellitus, and type 2 diabetes control were evaluated. Impulsivity was measured using the Impulsive Behavior Scale questionnaire and various cognitive measurements. Impulsivity z-scores were generated to obtain Global, Trait, and Behavioral Impulsivity domains. Linear mixed models were used to study the longitudinal associations across baseline, 1-year, and 3-year follow-up visits. HOMA-IR was not significantly related to impulsivity. Participants with higher HbA1c levels, type 2 diabetes, and poor control of diabetes showed positive associations with the Global Impulsivity domain over time, and those with higher HbA1c levels were further related to increases in the Trait and Behavioral Impulsivity domains over the follow-up visits. These results suggest a potential positive feedback loop between impulsivity and glycemic-related dysregulation.
   Previous studies have examined associations between glycemic-related factors and impulsivity, but mostly in cross-sectional studies with a lack of using both trait and behavioral impulsivity assessments together. Using the PREDIMED-Plus-Cognition cohort, several glycemic-related and impulsivity assessments were obtained over 3 years. Z-scores of impulsivity domains were obtained to provide a comprehensive impulsivity evaluation. Based on previous evidence, the current results suggest a positive feedback loop between impulsivity and glycemic dysregulations. image
C1 [Gomez-Martinez, Carlos; Babio, Nancy; Nishi, Stephanie K.; Salas-Salvado, Jordi] Univ Rovira i Virgili, Dept Bioquim Biotecnol, Grup Alimentacio Nutricio Desenvolupament & Salut, Unitat Nutricio Humana, Reus, Spain.
   [Gomez-Martinez, Carlos; Babio, Nancy; Nishi, Stephanie K.; Salas-Salvado, Jordi] Hosp Univi St Joan Reus, Inst Invest Sanitaria Pere Virgili IISPV, Reus, Spain.
   [Gomez-Martinez, Carlos; Babio, Nancy; Camacho-Barcia, Lucia; Nishi, Stephanie K.; Vazquez, Zenaida; Alvarez-Sala, Andrea; de la Torre, Rafael; Fanlo-Maresma, Marta; Corella, Dolores; Fernandez-Aranda, Fernando; Salas-Salvado, Jordi] Inst Salud Carlos III ISCIII, Ctr Invest Biomed Red Fisiopatol Obes & Nutr CIBER, Madrid, Spain.
   [Camacho-Barcia, Lucia; Fernandez-Aranda, Fernando] Bellvitge Univ Hosp, Dept Clin Psychol, Barcelona, Spain.
   [Camacho-Barcia, Lucia] Bellvitge Biomed Res Inst IDIBELL, Neurosci Programme, Psychoneurobiol Eating & Addict Behav Grp, Barcelona, Spain.
   [Julvez, Jordi] Inst Invest Sanitaria Pere Virgili IISPV, Clin & Epidemiol Neurosci Grp NeuroEpia, Reus, Spain.
   [Nishi, Stephanie K.] Toronto 3D Diet Digest Tract & Dis Knowledge Synth, Toronto, ON, Canada.
   [Nishi, Stephanie K.] St Michaels Hosp, Clin Nutr & Risk Factor Modificat Ctr, Unity Hlth Toronto, Toronto, ON, Canada.
   [Vazquez, Zenaida] Univ Navarra, Dept Prevent Med & Publ Hlth, Inst Invest Sanitaria Navarra IdISNA, Pamplona, Spain.
   [Forcano, Laura; Cuenca-Royo, Aida; de la Torre, Rafael; Tello, Susanna] Hosp Mar Med Res Inst IMIM, Neurosci Res Program, Integrat Pharmacol & Syst Neurosci Res Grp, Barcelona, Spain.
   [Alvarez-Sala, Andrea; Corella, Dolores] Univ Valencia, Dept Prevent Med, Valencia, Spain.
   [de la Torre, Rafael] Univ Pompeu Fabra UPF, Fac Expt & Hlth Sci, Barcelona, Spain.
   [Fanlo-Maresma, Marta] Hosp Univ Bellvitge IBIDELL, Hosp Llobregat, Lipids & Vasc Risk Unit, Internal Med, Barcelona, Spain.
   [Vasquez, Alejandro Arias; Franke, Barbara] Radboud Univ Nijmegen, Donders Inst Brain Cognit & Behav, Med Ctr, Dept Human Genet, Nijmegen, Netherlands.
   [Vasquez, Alejandro Arias; Franke, Barbara] Radboud Univ Nijmegen, Med Ctr, Donders Inst Brain Cognit & Behav, Dept Cognit Neurosci, Nijmegen, Netherlands.
   [Dalsgaard, Soren] Copenhagen Univ Hosp Mental Hlth Serv CPH, Child & Adolescent Mental Hlth Ctr, Copenhagen, Denmark.
   [Dalsgaard, Soren] Univ Copenhagen, Dept Clin Med, Copenhagen, Denmark.
   [Fernandez-Aranda, Fernando] Univ Barcelona, Sch Med & Hlth Sci, Dept Clin Sci, Barcelona, Spain.
C3 Universitat Rovira i Virgili; Universitat Rovira i Virgili; Institut
   d'Investigacio Sanitaria Pere Virgili (IISPV); University of Barcelona;
   Institut d'Investigacio Biomedica de Bellvitge (IDIBELL); Bellvitge
   University Hospital; Institut d'Investigacio Biomedica de Bellvitge
   (IDIBELL); Universitat Rovira i Virgili; Institut d'Investigacio
   Sanitaria Pere Virgili (IISPV); University of Toronto; Saint Michaels
   Hospital Toronto; University of Navarra; Hospital del Mar Research
   Institute; Hospital del Mar; University of Valencia; Pompeu Fabra
   University; University of Barcelona; Institut d'Investigacio Biomedica
   de Bellvitge (IDIBELL); Bellvitge University Hospital; Radboud
   University Nijmegen; Radboud University Nijmegen; University of
   Copenhagen; University of Barcelona
RP Babio, N; Salas-Salvadó, J (corresponding author), Univ Rovira i Virgili, Fac Med & Hlth Sci, Human Nutr Unit, C-St Llorenc 21, Reus 43201, Spain.
EM nancy.babio@urv.cat
RI Vasquez, A./L-4175-2015; Corella, Dolores/L-9888-2014; Babio,
   Nancy/AAN-2715-2020; Torre, Riccardo/N-9558-2014; Franke,
   Barbara/D-4836-2009; Camacho-Barcia, Lucía/AAB-2096-2021; Vázquez-Ruiz,
   Zenaida/AAB-7202-2020; Nishi, Stephanie/GSN-1143-2022; FERNANDEZ-ARANDA,
   FERNANDO/L-9762-2014; Julvez, Jordi/R-4531-2017; Salas-Salvado,
   Jordi/C-7229-2017; Gomez Martinez, Carlos/AGJ-6387-2022
OI FERNANDEZ-ARANDA, FERNANDO/0000-0002-2968-9898; Julvez,
   Jordi/0000-0003-0818-4003; Salas-Salvado, Jordi/0000-0003-2700-7459;
   Gomez Martinez, Carlos/0000-0002-3077-6702
FU Instituto de Salud Carlos III [PI20/00886, CD22/00171, CPII19/00015,
   PI13/00233, PI13/00272, PI13/00462, PI13/00492, PI13/00673, PI13/00728,
   PI13/01056, PI13/01090, PI13/01123, PI13/02184, PI14/00618, PI14/00636,
   PI14/00696, PI14/00728, PI14/00853, PI14/00972, PI14/01206, PI14/01374,
   PI14/01471, PI14/01722, PI14/01919, PI16/00366, PI16/00381, PI16/00473,
   PI16/00501, PI16/00533, PI16/00662, PI16/01094, PI16/01120, PI16/01522,
   PI16/01873, PI17/00215, PI17/00508, PI17/00525, PI17/00532, PI17/00764,
   PI17/00855, PI17/00926, PI17/01183, PI17/01347, PI17/01441, PI17/01732,
   PI17/01827, PI19/00017, PI19/00309, PI19/00386, PI19/00576, PI19/00781,
   PI19/00957, PI19/01032, PI19/01226, PI19/01332, PI19/01560, PI20/00138,
   PI20/00339, PI20/00456, PI20/00557, PI20/01158, PI20/01532, PI20/01802,
   FORT23/00032, PI20/132]; Universitat Rovira i Virgili [2020PMF-PIPF-37];
   Horizon 2020 Framework Programme [728018, 847879]; Consejeria de Salud y
   Bienestar Social, Junta de Andalucia [PI0137/2018, PI0458/2013,
   PS0358/2016]; Generalitat de Catalunya [SLT006/17/00246, 2021 SGR
   00824]; La Caixa' Foundation [2013ACUP00194]; Generalitat de Valenciana
   [APOSTD2020-164, PROMETEO/2017/017, PROMETEO/21/2021]; Ministerio de
   Ciencia e Innovacion, Madrid, Spain [PID2019-108858RB-I00]; Canadian
   Institutes of Health Research (CIHR) [MFE-171207]
FX Instituto de Salud Carlos III, Grant/Award Numbers: PI20/00886,
   CD22/00171, CPII19/00015, PI13/00233, PI13/00272, PI13/00462,
   PI13/00492, PI13/00673, PI13/00728, PI13/01056, PI13/01090, PI13/01123,
   PI13/02184, PI14/00618, PI14/00636, PI14/00696, PI14/00728, PI14/00853,
   PI14/00972, PI14/01206, PI14/01374, PI14/01471, PI14/01722, PI14/01919,
   PI16/00366, PI16/00381, PI16/00473, PI16/00501, PI16/00533, PI16/00662,
   PI16/01094, PI16/01120, PI16/01522, PI16/01873, PI17/00215, PI17/00508,
   PI17/00525, PI17/00532, PI17/00764, PI17/00855, PI17/00926, PI17/01183,
   PI17/01347, PI17/01441, PI17/01732, PI17/01827, PI19/00017, PI19/00309,
   PI19/00386, PI19/00576, PI19/00781, PI19/00957, PI19/01032, PI19/01226,
   PI19/01332, PI19/01560, PI20/00138, PI20/00339, PI20/00456, PI20/00557,
   PI20/01158, PI20/01532, PI20/01802, FORT23/00032, PI20/132; Universitat
   Rovira i Virgili, Grant/Award Number: 2020PMF-PIPF-37; Horizon 2020
   Framework Programme, Grant/Award Numbers: Eat2beNICE/H2020-SFS-2016-2,
   Ref 728018, PRIME/H2020-SC1-BHC-2018-2020, Ref: 847879; Consejeria de
   Salud y Bienestar Social, Junta de Andalucia, Grant/Award Numbers:
   PI0137/2018, PI0458/2013, PS0358/2016; Generalitat de Catalunya,
   Grant/Award Numbers: SLT006/17/00246, 2021 SGR 00824; 'la Caixa'
   Foundation, Grant/Award Number: 2013ACUP00194; Generalitat de
   Valenciana, Grant/Award Numbers: APOSTD2020-164, PROMETEO/2017/017,
   PROMETEO/21/2021; Ministerio de Ciencia e Innovacion, Madrid, Spain,
   Grant/Award Number: PID2019-108858RB-I00; Canadian Institutes of Health
   Research (CIHR), Grant/Award Number: MFE-171207
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NR 62
TC 0
Z9 0
U1 1
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0077-8923
EI 1749-6632
J9 ANN NY ACAD SCI
JI Ann. N.Y. Acad. Sci.
PD OCT
PY 2024
VL 1540
IS 1
BP 211
EP 224
DI 10.1111/nyas.15205
EA AUG 2024
PG 14
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA J8B6G
UT WOS:001291608200001
PM 39150983
OA hybrid
DA 2025-06-11
ER

PT J
AU Neuwirth, LS
   Gökhan, N
   Kaye, S
   Meehan, EF
AF Neuwirth, Lorenz S.
   Gokhan, Nurper
   Kaye, Sarrah
   Meehan, Edward F.
TI Taurine Supplementation for 48-Months Improved Glucose Tolerance and
   Changed ATP-Related Enzymes in Avians
SO PHARMACOLOGY
LA English
DT Article
DE Taurine; Glucose homeostasis; Bioenergetics; Insulin; Metabolism;
   Metabolic syndrome; Avians
ID DEVELOPMENTAL LEAD-EXPOSURE; SEX; BIRDS; INVOLVEMENT; EVOLUTION; SERVE
AB Avians differ from mammals, especially in brain architecture and metabolism. Taurine, an amino acid basic to metabolism and bioenergetics, has been shown to have remarkable effects on metabolic syndrome and ameliorating oxidative stress reactions across species. However, less is known regarding these metabolic relationships in the avian model. The present study serves as a preliminary report that examined how taurine might affect avian metabolism in an aged model system. Two groups of pigeons (Columba livia) of mixed sex, a control group and a group that received 48 months of taurine supplementation (0.05% w/v) in their drinking water, were compared by using blood panels drawn from their basilic vein by a licensed veterinarian. From the blood panel data, taurine treatment generated higher levels of three ATP-related enzymes: glutamate dehydrogenase (GLDH), lactate dehydrogenase (LDH), and creatine kinase (CK). In this preliminary study, the role that taurine treatment might play in the adult aged pigeon's metabolism on conserved traits such as augmenting insulin production as well as non-conserved traits maintaining high levels of ATP-related enzymes was examined. It was found that taurine treatment influenced the avian glucose metabolism similar to mammals but differentially effected avian ATP-related enzymes in a unique way (i.e., & SIM;x2 increase in CK and LDH with a nearly x4 increase in GLDH). Notably, long-term supplementation with taurine had no negative effect on parameters of lipid and protein metabolism nor liver enzymes. The preliminary study suggests that avians may serve as a unique model system for investigating taurine metabolism across aging with long-term health implications (e.g., hyperinsulinemia). However, the suitability of using the model would require researchers to tightly control for age, sex, dietary intake, and exercise conditions as laboratory-housed avian present with very different metabolic panels than free-flight avians, and their metabolic profile may not correlate one-to-one with mammalian data.
C1 [Neuwirth, Lorenz S.] SUNY Old Westbury, Long Isl City, NY 11568 USA.
   [Neuwirth, Lorenz S.] SUNY Neurosci Res Inst, Long Isl City, NY 11568 USA.
   [Gokhan, Nurper] CUNY, LaGuardia Community Coll, Dept Social Sci, Long Isl City, NY USA.
   [Kaye, Sarrah] Staten Isl Zool Soc, Staten Isl, NY USA.
   [Meehan, Edward F.] CUNY, Dept Psychol, Coll Staten Isl, Staten Isl, NY USA.
   [Meehan, Edward F.] Ctr Dev Neurosci, Staten Isl, NY USA.
C3 State University of New York (SUNY) System; SUNY Old Westbury; City
   University of New York (CUNY) System; City University of New York (CUNY)
   System; College of Staten Island (CUNY)
RP Neuwirth, LS (corresponding author), SUNY Old Westbury, Long Isl City, NY 11568 USA.; Neuwirth, LS (corresponding author), SUNY Neurosci Res Inst, Long Isl City, NY 11568 USA.
EM NeuwirthL@oldwestbury.edu
RI Neuwirth, Lorenz/AAE-3879-2019
OI Neuwirth, Lorenz/0000-0002-8194-522X
FU PSC-CUNY [PSCREG-41-1064]
FX The work was supported in part by PSC-CUNY grant(PSCREG-41-1064) awarded
   to E.F.M.
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NR 44
TC 2
Z9 2
U1 1
U2 1
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0031-7012
EI 1423-0313
J9 PHARMACOLOGY
JI Pharmacology
PD NOV
PY 2023
VL 108
IS 6
BP 599
EP 606
DI 10.1159/000533538
EA SEP 2023
PG 8
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA AK3V1
UT WOS:001065659300001
PM 37703842
OA hybrid
DA 2025-06-11
ER

PT J
AU Pastori, D
   Baratta, F
   Carnevale, R
   Cangemi, R
   Del Ben, M
   Bucci, T
   Polimeni, L
   Labbadia, G
   Nocella, C
   Scardella, L
   Pani, A
   Pignatelli, P
   Violi, F
   Angelico, F
AF Pastori, Daniele
   Baratta, Francesco
   Carnevale, Roberto
   Cangemi, Roberto
   Del Ben, Maria
   Bucci, Tommaso
   Polimeni, Licia
   Labbadia, Giancarlo
   Nocella, Cristina
   Scardella, Laura
   Pani, Arianna
   Pignatelli, Pasquale
   Violi, Francesco
   Angelico, Francesco
TI Similar Reduction of Cholesterol-Adjusted Vitamin E Serum Levels in
   Simple Steatosis and Non-Alcoholic Steatohepatitis
SO CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY
LA English
DT Article
ID FATTY LIVER-DISEASE; OXIDATIVE STRESS; METABOLIC SYNDROME;
   ALPHA-TOCOPHEROL; E CONSUMPTION; MANAGEMENT; DIAGNOSIS; RISK;
   GUIDELINES; SEVERITY
AB OBJECTIVES: Reduced vitamin E levels have been reported in patients with non-alcoholic steatohepatitis (NASH), but no conclusive data on patients with simple steatosis (SS) are available. Aim of this study was to investigate the association between serum vitamin E levels and SS.
   METHODS: A cohort of 312 patients with cardio-metabolic risk factors was screened for liver steatosis by ultrasonography (US). We reasonably classified as SS patients with US-fatty liver, normal liver function tests (LFTs) and with Cytokeratin 18 <246 mIU/ml. Liver biopsy was performed in 41 patients with US-fatty liver and persistent elevation of LFTs (46 months). Serum cholesterol-adjusted vitamin E (Vit E/chol) levels were measured.
   RESULTS: Mean age was 53.9 +/- 12.5 years and 38.4% were women. Non-alcoholic fatty liver disease (NAFLD) was detected at US in 244 patients; of those 39 had biopsy-proven NASH and 2 borderline NASH. Vit E/chol was reduced in both SS (3.4 +/- 2.0, P<0.001), and NASH (3.5 +/- 2.1, P = 0.006) compared with non-NAFLD patients (4.8 +/- 2.0 mu mol/mmol chol). No difference was found between SS and NASH (P = 0.785). After excluding patients with NASH, a multivariable logistic regression analysis found that Vit E/chol (odds ratio (OR): 0.716, 95% confidence interval (CI) 0.602-0.851, P<0.001), alanine aminotransferase (ALT, OR: 1.093, 95% CI 1.029-1.161, P = 0.004), body mass index (OR: 1.162, 95% CI 1.055-1.279, P = 0.002) and metabolic syndrome (OR: 5.725, 95% CI 2.247-14.591, P<0.001) were factors independently associated with the presence of SS.
   CONCLUSIONS: Reduced vitamin E serum levels are associated with SS, with a similar reduction between patients with SS and NASH, compared with non-NAFLD patients. Our findings suggest that the potential benefit of vitamin E supplementation should be investigated also in patients with SS.
C1 [Pastori, Daniele; Baratta, Francesco; Carnevale, Roberto; Cangemi, Roberto; Del Ben, Maria; Bucci, Tommaso; Polimeni, Licia; Labbadia, Giancarlo; Nocella, Cristina; Pani, Arianna; Pignatelli, Pasquale; Violi, Francesco] Univ Roma La Sapienza, Dept Internal Med & Med Specialties, I-00161 Rome, Italy.
   [Pastori, Daniele; Baratta, Francesco; Polimeni, Licia] Dept Anat Histol Forens Med & Orthoped Sci, Rome, Italy.
   [Carnevale, Roberto] Univ Roma La Sapienza, Dept Med Surg Sci & Biotechnol, Latina, Italy.
   [Scardella, Laura] Univ Roma La Sapienza, Dept Surg Sci, I-00161 Rome, Italy.
   [Angelico, Francesco] Univ Roma La Sapienza, Dept Publ Hlth & Infect Dis, I-00161 Rome, Italy.
C3 Sapienza University Rome; Sapienza University Rome; Sapienza University
   Rome; Sapienza University Rome
RP Angelico, F (corresponding author), Univ Roma La Sapienza, Dept Publ Hlth & Infect Dis, Med Clin 1, Policlin Umberto I, Viale Policlin 155, I-00161 Rome, Italy.
EM francesco.angelico@uniroma1.it
RI Carnevale, Roberto/JMC-1138-2023; Pani, Arianna/AAB-2572-2019; Del Ben,
   Maria/AAE-7603-2020; Angelico, Francesco/AAB-6585-2020; Carnevale,
   Roberto/K-1472-2016; pastori, daniele/J-7087-2016; pignatelli,
   pasquale/K-2116-2016; Violi, Francesco/K-1509-2016; nocella,
   cristina/K-2175-2016; Bucci, Tommaso/ABA-4162-2021
OI Carnevale, Roberto/0000-0002-6216-9595; Pani,
   Arianna/0000-0001-6464-2596; pastori, daniele/0000-0001-6357-5213;
   pignatelli, pasquale/0000-0002-2265-7455; Cangemi,
   Roberto/0000-0002-4097-2061; Violi, Francesco/0000-0002-6610-7068;
   nocella, cristina/0000-0003-4398-6327; Bucci,
   Tommaso/0000-0003-2895-6234; Baratta, Francesco/0000-0003-1708-272X
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NR 35
TC 22
Z9 22
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
EI 2155-384X
J9 CLIN TRANSL GASTROEN
JI Clin. Transl. Gastroenterol.
PD OCT
PY 2015
VL 6
AR e113
DI 10.1038/ctg.2015.43
PG 6
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA DG5GG
UT WOS:000372104100001
PM 26426796
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Nemer, M
   Osman, F
   Said, A
AF Nemer, Mary
   Osman, Fauzia
   Said, Adnan
TI Dietary macro and micronutrients associated with MASLD: Analysis of a
   national US cohort database
SO ANNALS OF HEPATOLOGY
LA English
DT Article
DE Metabolic Syndrome Associated Steatotic Liver Disease (MASLD); Diet;
   National Health and Nutrition Examination Survey (NHANES); Nutrition;
   Vitamins; Calories
ID FATTY LIVER-DISEASE; VITAMIN-E; NONALCOHOLIC STEATOHEPATITIS;
   INSULIN-RESISTANCE; HEALTH LITERACY; WEIGHT-LOSS; MARRIAGE; NAFLD;
   STEATOSIS; NUTRITION
AB Introduction and Objectives: Our objective was to measure and compare the intake of macro and micronutrients in a cohort of individuals with Metabolic Syndrome Associated Steatotic Liver Disease (MASLD) compared with matched controls to identify areas of further research in this area; we identified nutritionassociated associations with MASLD in the United States general population. Materials and Methods: We used the 2017 - 2018 NHANES dataset. Elastography Controlled Attenuation Parameter (CAP score>280) in the absence of other liver disease was defined as MASLD in adults (>18). Advanced fibrosis was defined by transient elastography >10 kPa. Controls were adults without liver disease. Results: 1648 MASLD cases (11.4 % advanced fibrosis) and 2527 controls were identified. MASLD cases were older (P<0.001), more likely males (P = 0.01), less likely to have a college education (P = 0.04) and more likely married (P = 0.002). MASLD cases were more likely to be of Mexican American or Hispanic ethnicity (P = 0.002), have higher BMI, higher prevalence of diabetes, hyperlipidemia and hypertension (P<0.001 for all). MASLD cases had higher hs-CRP (P = 0.02) and ferritin (P = 0.02). MASLD cases had lower total (P = 0.004) and added vitamin E in their diet (P = 0.002), lower vitamin K intake (P = 0.005), and higher Selenium intake (P = 0.03). Caloric intake (P = 0.04), carbohydrate intake (P = 0.02), cholesterol intake (P = 0.03) and saturated fatty acid intake (P = 0.05) were higher in MASLD. Individuals with MASLD were more likely to be on a diet (P<0.001), sedentary (P = 0.008) and less likely to participate in moderate or vigorous recreational activities (P<0.001). Conclusions: The deficiencies of micronutrients and excess of macronutrients point to oxidative stress, proinflammatory state, and lipotoxicity as pathways linking the US diet to MASLD. MASLD patients are more often on special diets, which may reflect prior provider counseling on diet changes to improve health.
C1 [Nemer, Mary] Med Coll Wisconsin, Dept Med Gastroenterol & Hepatol, Milwaukee, WI USA.
   [Osman, Fauzia] Univ Wisconsin, Sch Med & Publ Hlth, Dept Med, Biostat, Madison, WI USA.
   [Said, Adnan] Univ Wisconsin, Sch Med & Publ Hlth, Dept Med, Div Gastroenterol & Hepatol, Madison, WI 53706 USA.
   [Said, Adnan] Wm S Middleton VA Med Ctr, Madison, WI 53705 USA.
C3 Medical College of Wisconsin; University of Wisconsin System; University
   of Wisconsin Madison; University of Wisconsin System; University of
   Wisconsin Madison
RP Said, A (corresponding author), Univ Wisconsin, Sch Med & Publ Hlth, Dept Med, Div Gastroenterol & Hepatol, Madison, WI 53706 USA.; Said, A (corresponding author), Wm S Middleton VA Med Ctr, Madison, WI 53705 USA.
EM axs@medicine.wisc.edu
OI Osman, Fauzia/0000-0003-1323-9857
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NR 67
TC 7
Z9 7
U1 2
U2 6
PU ELSEVIER ESPANA
PI MADRID
PA CALLE DE ZURBANO, 76-4TH FLR LEFT, MADRID, 28010, SPAIN
SN 1665-2681
J9 ANN HEPATOL
JI Ann. Hepatol.
PD MAY-JUN
PY 2024
VL 29
IS 3
AR 101491
DI 10.1016/j.aohep.2024.101491
EA MAR 2024
PG 7
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA OS2O1
UT WOS:001209201200001
PM 38412922
OA gold
DA 2025-06-11
ER

PT J
AU Ibrahim, SM
   El-Denshary, ES
   Abdallah, DM
AF Ibrahim, Sherehan M.
   El-Denshary, Ezzedin S.
   Abdallah, Dalaal M.
TI Geraniol, Alone and in Combination with Pioglitazone, Ameliorates
   Fructose-Induced Metabolic Syndrome in Rats via the Modulation of Both
   Inflammatory and Oxidative Stress Status
SO PLOS ONE
LA English
DT Article
ID NECROSIS-FACTOR-ALPHA; GLYCATION END-PRODUCTS; INSULIN-RESISTANCE;
   PPAR-GAMMA; ADIPOSE-TISSUE; UP-REGULATION; NITRIC-OXIDE; URIC-ACID;
   RECEPTOR; ADIPONECTIN
AB Geraniol (GO) potent antitumor and chemopreventive effects are attributed to its antioxidant and anti-inflammatory properties. In the current study, the potential efficacy of GO (250 mg/kg) in ameliorating metabolic syndrome (MetS) induced by fructose in drinking water was elucidated. Moreover, the effect of pioglitazone (5 and 10 mg/kg; PIO) and the possible interaction of the co-treatment of GO with PIO5 were studied in the MetS model. After 4 weeks of treatment, GO and/or PIO reduced the fasting blood glucose and the glycemic excursion in the intraperitoneal glucose tolerance test. GO and PIO5/10 restrained visceral adiposity and partly the body weight gain. The decreased level of peroxisome proliferator activated receptor (PPAR)-gamma transcriptional activity in the visceral adipose tissue of MetS rats was increased by single treatment regimens. Though GO did not affect MetS-induced hyperinsulinemia, PIO5/10 lowered it. Additionally, GO and PIO5/10 suppressed glycated hemoglobin and the receptor for advanced glycated end products (RAGE). These single regimens also ameliorated hyperuricemia, the disrupted lipid profile, and the elevated systolic blood pressure evoked by MetS. The rise in serum transaminases, interleukin-1 beta, and tumor necrosis factor-alpha, as well as hepatic lipid peroxides and nitric oxide (NO) was lowered by the single treatments to different extents. Moreover, hepatic non-protein thiols, as well as serum NO and adiponectin were enhanced by single regimens. Similar effects were reached by the combination of GO with PIO5; however, a potentiative interaction was noted on fasting serum insulin level, while synergistic effects were reflected as improved insulin sensitivity, as well as reduced RAGE and triglycerides. Therefore, GO via the transcriptional activation of PPAR-gamma reduces inflammation and free radical injury produced by MetS. Thereby, these effects provide novel mechanistic insights on GO management of MetS associated critical risk factors. Moreover, the co-administration of GO to PIO5 exalted the antidiabetic drug anti-MetS efficacy.
C1 [Ibrahim, Sherehan M.; El-Denshary, Ezzedin S.; Abdallah, Dalaal M.] Cairo Univ, Fac Pharm, Dept Pharmacol & Toxicol, Cairo, Egypt.
C3 Egyptian Knowledge Bank (EKB); Cairo University
RP Abdallah, DM (corresponding author), Cairo Univ, Fac Pharm, Dept Pharmacol & Toxicol, Cairo, Egypt.
EM dalabdallah@staff.cu.edu.eg
RI Abdallah, Dalaal/GVT-0783-2022
OI , Sherehan/0000-0003-3495-3451
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NR 75
TC 52
Z9 55
U1 0
U2 14
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD FEB 13
PY 2015
VL 10
IS 2
AR e0117516
DI 10.1371/journal.pone.0117516
PG 17
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA CC9IO
UT WOS:000350682600070
PM 25679220
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Sohn, C
   Kim, J
   Bae, W
AF Sohn, Cheongmin
   Kim, Juyong
   Bae, Wookyung
TI The framingham risk score, diet, and inflammatory markers in Korean men
   with metabolic syndrome
SO NUTRITION RESEARCH AND PRACTICE
LA English
DT Article
DE Framingham risk score; inflammation; polyunsaturated fatty acid;
   antioxidant; metabolic syndrome
ID CORONARY-HEART-DISEASE; C-REACTIVE PROTEIN; EXAMINATION SURVEY III;
   CARDIOVASCULAR-DISEASE; OXIDATIVE STRESS; PRIMARY PREVENTION;
   NATIONAL-HEALTH; 7 COUNTRIES; MORTALITY; ADULTS
AB The Framingham risk score (FRS) has been used to assess the risk of a cardiovascular event and to identify patients for risk factor modifications. Therefore, the purpose of this study was to evaluate the relationship of the FRS with dietary intake and inflammatory biomarkers. We conducted a cross-sectional study of 180 men (49.2 +/- 10.2 years) with MS. Serum levels of high sensitive C-reactive protein (hs-CRP), interleukin-6 (IL-6), and adiponectin were examined. Participants were asked to complete the food frequency questionnaire (FFQ) using the previous 1 year as a reference point. The absolute cardiovascular disease (CVD) risk percentage over 10 years was calculated to estimate the FRS, which was classified as low risk (< 10%), intermediate risk (10-20%), and high risk (> 20%). Mean intake of polyunsaturated fatty acids was lower in subjects who had > 20% FRS than in subjects who had < 10% FRS (3.7 +/- 1.9 g/day vs. 4.7 +/- 1.9 g/day; P < 0.05). Significant differences in the Index of Nutritional Quality of protein, phosphorus, iron, vitamin A, vitamin B-1, niacin, vitamin B-6, and vitamin C were observed between the > 20% FRS group and the < 10% FRS group (P < 0.05). IL-6 concentrations were significantly lower in subjects with a < 10% FRS than in subjects who were 10-20% FRS or > 20% FRS (0.91 +/- 0.26 vs. 1.48 +/- 033 vs. 2.72 +/- 0.57 pg/mL, respectively; P < 0.05). IL-6 and dietary intake of polyunsaturated fatty acids together explained 6.6% of the variation in FRS levels in a stepwise multiple regression model. Our results provide some evidence that dietary intake in the higher CVD risk group was inferior to that in the lower risk group and that dietary fat intake and IL-6 were associated with FRS and MS in Korean men.
C1 [Sohn, Cheongmin] Wonkwang Univ, Iksan 570749, Jeonbuk, South Korea.
   [Kim, Juyong; Bae, Wookyung] Seoul Natl Univ, Bundang Hosp, Hlth Promot Ctr, Songnam 463707, South Korea.
C3 Wonkwang University; Seoul National University (SNU)
RP Sohn, C (corresponding author), Wonkwang Univ, 344-2 Sinyong Dong, Iksan 570749, Jeonbuk, South Korea.
EM ccha@wku.ac.kr
OI Sohn, Cheongmin/0000-0003-0529-7037
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NR 53
TC 43
Z9 45
U1 0
U2 6
PU KOREAN NUTRITION SOC
PI SEOUL
PA 804 KST CTR, 635-4 YEOGSAM-SONG KANGNAM-KU, SEOUL, 135-703, SOUTH KOREA
SN 1976-1457
EI 2005-6168
J9 NUTR RES PRACT
JI Nutr. Res. Pract.
PD JUN
PY 2012
VL 6
IS 3
BP 246
EP 253
DI 10.4162/nrp.2012.6.3.246
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 970WL
UT WOS:000306162900010
PM 22808350
OA Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Cong, SB
   Wang, SL
   Qiao, YF
   Gu, SX
   Liu, SS
   Chai, XL
   Zhang, YS
AF Cong, Shibo
   Wang, Sili
   Qiao, Yanfang
   Gu, Shuxiao
   Liu, Susu
   Chai, Xinlou
   Zhang, Yongsheng
TI Emerging trends and hotspots in the links between the bile acids and
   NAFLD from 2002 to 2022: A bibliometric analysis
SO ENDOCRINOLOGY DIABETES & METABOLISM
LA English
DT Article
DE bibliometric analysis; bile acids; cluster; hotspots; NAFLD
ID OBETICHOLIC ACID; SCIENTOMETRIC ANALYSIS; RECEPTOR; TGR5; FXR;
   MULTICENTER; METABOLISM; DISEASE
AB Background Non-alcoholic fatty liver disease (NAFLD) is a metabolic syndrome of the liver, and its incidence is increasing worldwide. Accumulating evidence suggests that bile acids are associated with NAFLD. Although many studies on bile acids and NAFLD have been published over the past 20 years, the authors of this study have not found a relevant bibliometric analysis in this field. Therefore, this study aimed to evaluate the trend of publications, summarize current research hotspots and predict future research directions through bibliometric analysis in this field.Method Articles related to bile acids and NAFLD published between 2002 and 2022 were obtained from the Science Citation Index-Expanded of Web of Science Core Collection. Microsoft Excel, CiteSpace, VOSviewer and Bibliometric Online Analysis Platform were used to analyse the publication trends and research hotspots in this field.Results Among the articles published between 2002 and 2022, we retrieved 1284 articles related to bile acids and NAFLD, and finally included 568 articles. The USA was dominant until 2020, after which China surpassed the USA to become the dominant force. These two countries cooperate the most closely, and are also the most active in international cooperation. The University of California (UCL) was the most published institution, with a total of 31 publications. There were six authors who have published nine articles and ranked first. The keywords cluster labels show the 10 main clusters: #0fatty liver, #1obeticholic acid, #2oxidative stress, #37 alpha hydroxy 4 cholesten 3 one, #4deoxycholic acid, #5nonalcoholic fatty liver disease, #6mouse model, #7fibroblast growth factor 21, #8animal models, #9high-fat diet. Keywords burst analysis revealed a higher intensity of study for the nuclear receptor, FXR, and metabolic syndrome.Conclusion Bile acids have become an important research direction in the field of NAFLD, and the intervention of gut microbiota in NAFLD by acting on bile acids may become a potential hotspot for future research. This study provides reference and guidance for future research, and will help scholars better explore the field and innovatively discover the mechanisms and treatments of NAFLD.
C1 [Cong, Shibo; Wang, Sili; Qiao, Yanfang; Gu, Shuxiao; Liu, Susu; Chai, Xinlou] Beijing Univ Chinese Med, Coll Chinese Med, Beijing, Peoples R China.
   [Zhang, Yongsheng] Beijing Univ Chinese Med, Dongfang Hosp, 6 Fangxingyuan 1st Block, Beijing 100078, Peoples R China.
C3 Beijing University of Chinese Medicine; Beijing University of Chinese
   Medicine
RP Zhang, YS (corresponding author), Beijing Univ Chinese Med, Dongfang Hosp, 6 Fangxingyuan 1st Block, Beijing 100078, Peoples R China.
EM zhyshengcm@163.com
RI cong, shibo/HCG-9761-2022
OI CONG, shibo/0000-0002-7214-3233
FU Publisherapos;s note.
FX Throughout the writing of this article, we have received a great deal of
   support and assistance. We would particularly like to acknowledge my
   teammates for their wonderful collaboration and patient support.r
   Publisher & apos;s note.
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NR 45
TC 3
Z9 3
U1 0
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
EI 2398-9238
J9 ENDOCRIN DIAB METAB
JI Endocrinol. Diabetes Metab.
PD JAN
PY 2024
VL 7
IS 1
AR e460
DI 10.1002/edm2.460
EA NOV 2023
PG 16
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA EJ9T3
UT WOS:001101530200001
PM 37941122
OA gold
DA 2025-06-11
ER

PT J
AU Nizami, HL
   Katare, PB
   Prabhakar, P
   Adela, R
   Sarkar, S
   Arava, S
   Chakraborty, P
   Maulik, SK
   Banerjee, SK
AF Nizami, Hina L.
   Katare, Parmeshwar B.
   Prabhakar, Pankaj
   Adela, Ramu
   Sarkar, Soumalya
   Arava, Sudheer
   Chakraborty, Praloy
   Maulik, Subir K.
   Banerjee, Sanjay K.
TI Paricalcitol Attenuates Metabolic Syndrome-Associated Heart Failure
   through Enhanced Mitochondrial Fusion
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Article
ID VITAMIN-D-RECEPTOR; CHRONIC KIDNEY-DISEASE; CARDIAC-HYPERTROPHY;
   OXIDATIVE STRESS; ENDOTHELIAL FUNCTION; D SUPPLEMENTATION; FIBROSIS;
   EXPRESSION; PRESSURE; BIOENERGETICS
AB Objectives. Transition from cardiac hypertrophy to failure involves adverse metabolic reprogramming involving mitochondrial dysfunction. We have earlier shown that vitamin D deficiency induces heart failure, at least in part, through insulin resistance. However, whether activation of vitamin D receptor (VDR) can attenuate heart failure and underlying metabolic phenotype requires investigation. Thus, we aimed to assess the cardioprotective potential of paricalcitol, a vitamin D receptor-activator, against cardiac hypertrophy and failure in high-fat high-fructose-fed rats. Methods. Male Sprague Dawley rats were fed control (Con) or high-fat high-fructose (HFHFrD) diet for 20 weeks. After 12 weeks, rats from HFHFrD group were divided into the following: HFHFrD, HFHFrD+P (paricalcitol i.p. 0.08 mu g/kg/day) and HFHFrD+E (enalapril maleate i.p. 10 mg/kg/day). Intraperitoneal glucose tolerance test, blood pressure measurement, and 2D echocardiography were performed. Cardiac fibrosis was assessed by Masson's trichrome staining of paraffin-embedded heart sections. Mitochondrial DNA and proteins, and citrate synthase activity were measured in rat hearts. VDR was silenced in H9c2 cardiomyoblasts, and immunoblotting was performed. Results. Paricalcitol improved glucose tolerance, serum lipid profile, and blood pressure in high-fat high-fructose-fed rats. Paricalcitol reduced cardiac wall thickness and increased ejection fraction in high-fat high-fructose-fed rats but had no effect on perivascular fibrosis. PGC1-alpha was upregulated in the HFHFrD+P group compared to the HFHFrD group, but there was no significant difference in mitochondrial content. Citrate synthase activity was significantly higher in the HFHFrD+P group compared to the HFHFrD group. Rat hearts of the HFHFrD+P group had significantly higher expression of mitofusins. H9c2 cells with VDR knockdown showed significantly lower expression of Mfn2. Improvement in the HFHFrD+P group was comparable with that in the HFHFrD+E group. Conclusions. Paricalcitol reverses cardiac dysfunction in rats with metabolic syndrome by enhancing mitochondrial fusion. We demonstrate repurposing potential of the drug currently used in end-stage kidney disease.
C1 [Nizami, Hina L.; Katare, Parmeshwar B.; Sarkar, Soumalya; Banerjee, Sanjay K.] Translat Hlth Sci & Technol Inst THSTI, Noncommunicable Dis Grp, Faridabad 121001, India.
   [Prabhakar, Pankaj; Maulik, Subir K.] All India Inst Med Sci AIIMS, Dept Pharmacol, New Delhi 110029, India.
   [Adela, Ramu] All India Inst Med Sci AIIMS, Dept Endocrinol, New Delhi 110029, India.
   [Arava, Sudheer] All India Inst Med Sci AIIMS, Dept Pathol, New Delhi 110029, India.
   [Chakraborty, Praloy] VMMC & Safdarjung Hosp, Cardiol Dept, New Delhi 110029, India.
   [Banerjee, Sanjay K.] Natl Inst Pharmaceut Educ & Res, Dept Biotechnol, Gauhati 781101, India.
C3 Department of Biotechnology (DBT) India; Translational Health Science &
   Technology Institute (THSTI); All India Institute of Medical Sciences
   (AIIMS) New Delhi; All India Institute of Medical Sciences (AIIMS) New
   Delhi; All India Institute of Medical Sciences (AIIMS) New Delhi;
   Vardhman Mahavir Medical College & Safdarjung Hospital; National
   Institute of Pharmaceutical Education & Research, S.A.S. Nagar (Mohali)
RP Banerjee, SK (corresponding author), Translat Hlth Sci & Technol Inst THSTI, Noncommunicable Dis Grp, Faridabad 121001, India.; Banerjee, SK (corresponding author), Natl Inst Pharmaceut Educ & Res, Dept Biotechnol, Gauhati 781101, India.
EM hina.lateef012@gmail.com; pbkatare@gmail.com; pprabhakaraiims@gmail.com;
   ramuadela@gmail.com; sarkar.soumalya12@gmail.com; aravaaiims@gmail.com;
   praloyc@hotmail.com; skmaulik@gmail.com;
   sanjayk.banerjee@niperguwahati.ac.in
RI Prabhakar, Dr. Pankaj/GOH-1003-2022; Sarkar, Soumalya/AAS-5485-2021;
   Arava, Sudheer/AAF-7593-2020; Adela, Ramu/HKO-9169-2023; Banaś,
   Elżbieta/W-4583-2017; Banerjee, Sanjay/F-2677-2019
OI Sarkar, Soumalya/0000-0001-6480-687X; Prabhakar, Dr.
   Pankaj/0000-0002-1630-4258; Banerjee, Sanjay/0000-0002-4478-7189; Adela,
   Ramu/0000-0003-0909-2557; Nizami, Hina Lateef/0000-0001-9946-5673;
   Banerjee, Sanjay k/0000-0002-0044-0984
FU THSTI Core Funds; CSIR; ICMR
FX THSTI Core Funds supported this work. The authors wish to acknowledge
   CSIR and ICMR for providing Senior Research Fellowships to HLN and PBK,
   respectively.
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NR 52
TC 4
Z9 5
U1 0
U2 15
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PD JUN 11
PY 2022
VL 2022
AR 5554290
DI 10.1155/2022/5554290
PG 13
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA 2G9EQ
UT WOS:000813904400004
PM 35726330
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Carll, AP
   Crespo, SM
   Filho, MS
   Zati, DH
   Coull, BA
   Diaz, EA
   Raimundo, RD
   Jaeger, TNG
   Ricci-Vitor, AL
   Papapostolou, V
   Lawrence, JE
   Garner, DM
   Perry, BS
   Harkema, JR
   Godleski, JJ
AF Carll, Alex P.
   Crespo, Samir M.
   Filho, Mauricio S.
   Zati, Douglas H.
   Coull, Brent A.
   Diaz, Edgar A.
   Raimundo, Rodrigo D.
   Jaeger, Thomas N. G.
   Ricci-Vitor, Ana Laura
   Papapostolou, Vasileios
   Lawrence, Joy E.
   Garner, David M.
   Perry, Brigham S.
   Harkema, Jack R.
   Godleski, John J.
TI Inhaled ambient-level traffic-derived particulates decrease cardiac
   vagal influence and baroreflexes and increase arrhythmia in a rat model
   of metabolic syndrome
SO PARTICLE AND FIBRE TOXICOLOGY
LA English
DT Article
DE Particulate matter; Secondary organic aerosol; Baroreflex; Heart rate
   variability; Autonomic; Arrhythmia; Traffic; Respiratory;
   Cardiopulmonary
ID HEART-RATE-VARIABILITY; AIR-POLLUTION; BLOOD-PRESSURE; PARTICLE NUMBER;
   INFLAMMATORY RESPONSES; CONTROLLED EXPOSURE; CARBON PARTICLES; OXIDATIVE
   STRESS; DIESEL EXHAUST; URBAN STREET
AB Background: Epidemiological studies have linked exposures to ambient fine particulate matter (PM2.5) and traffic with autonomic nervous system imbalance (ANS) and cardiac pathophysiology, especially in individuals with preexisting disease. It is unclear whether metabolic syndrome (MetS) increases susceptibility to the effects of PM2.5. We hypothesized that exposure to traffic-derived primary and secondary organic aerosols (P + SOA) at ambient levels would cause autonomic and cardiovascular dysfunction in rats exhibiting features of MetS. Male Sprague Dawley (SD) rats were fed a high-fructose diet (HFrD) to induce MetS, and exposed to P + SOA (20.4 +/- 0.9 mu g/m(3)) for 12 days with time-matched comparison to filtered-air (FA) exposed MetS rats; normal diet (ND) SD rats were separately exposed to FA or P + SOA (56.3 +/- 1.2 mu g/m(3)).
   Results: In MetS rats, P + SOA exposure decreased HRV, QTc, PR, and expiratory time overall (mean effect across the entirety of exposure), increased breathing rate overall, decreased baroreflex sensitivity (BRS) on three exposure days, and increased spontaneous atrioventricular (AV) block Mobitz Type II arrhythmia on exposure day 4 relative to FA-exposed animals receiving the same diet. Among ND rats, P + SOA decreased HRV only on day 1 and did not significantly alter BRS despite overall hypertensive responses relative to FA. Correlations between HRV, ECG, BRS, and breathing parameters suggested a role for autonomic imbalance in the pathophysiologic effects of P + SOA among MetS rats. Autonomic cardiovascular responses to P + SOA at ambient PM2.5 levels were pronounced among MetS rats and indicated blunted vagal influence over cardiovascular physiology.
   Conclusions: Results support epidemiologic findings that MetS increases susceptibility to the adverse cardiac effects of ambient-level PM2.5, potentially through ANS imbalance.
C1 [Carll, Alex P.; Crespo, Samir M.; Filho, Mauricio S.; Zati, Douglas H.; Coull, Brent A.; Diaz, Edgar A.; Raimundo, Rodrigo D.; Jaeger, Thomas N. G.; Ricci-Vitor, Ana Laura; Papapostolou, Vasileios; Lawrence, Joy E.; Perry, Brigham S.; Godleski, John J.] Harvard TH Chan Sch Publ Hlth, Dept Environm Hlth, Boston, MA 02115 USA.
   [Carll, Alex P.] Univ Louisville, Sch Med, Diabet & Obes Ctr, Dept Physiol, 580 South Preston St,Delia Baxter Bldg,Room 404B, Louisville, KY 40202 USA.
   [Crespo, Samir M.; Filho, Mauricio S.; Zati, Douglas H.; Jaeger, Thomas N. G.] Univ Sao Paulo, Sch Med, Sao Paulo, Brazil.
   [Raimundo, Rodrigo D.] Univ Sao Paulo, Fac Publ Hlth, Sao Paulo, Brazil.
   [Ricci-Vitor, Ana Laura] Univ Fed Sao Paulo, Sao Paulo, Brazil.
   [Garner, David M.] Oxford Brookes Univ, Fac Hlth & Life Sci, Oxford, England.
   [Harkema, Jack R.] Michigan State Univ, Dept Pathobiol, E Lansing, MI 48824 USA.
C3 Harvard University; Harvard T.H. Chan School of Public Health;
   University of Louisville; Universidade de Sao Paulo; Universidade de Sao
   Paulo; Universidade Federal de Sao Paulo (UNIFESP); Oxford Brookes
   University; Michigan State University
RP Carll, AP (corresponding author), Harvard TH Chan Sch Publ Hlth, Dept Environm Hlth, Boston, MA 02115 USA.; Carll, AP (corresponding author), Univ Louisville, Sch Med, Diabet & Obes Ctr, Dept Physiol, 580 South Preston St,Delia Baxter Bldg,Room 404B, Louisville, KY 40202 USA.
EM alex.carll@louisville.edu
RI Raimundo, Rodrigo/Z-6342-2019; DIAZ, EDGAR/A-6079-2012; Ricci-Vitor,
   Ana/Y-4135-2019; Ricci-Vitor, Ana Laura/F-3571-2014; Carll,
   Alex/O-5764-2018; Daminello Raimundo, Rodrigo/C-6660-2016
OI Ricci-Vitor, Ana Laura/0000-0002-3654-8532; Garner, David
   M./0000-0002-8114-9055; Carll, Alex/0000-0003-1832-3070; Daminello
   Raimundo, Rodrigo/0000-0002-3043-0728; Diaz, Edgar/0000-0002-9076-6549
FU USEPA [R83479701, RD-83479801]; NHLBI [T-32 HL007118]
FX This publication was made possible by USEPA grants R83479701 and
   RD-83479801. Its contents are solely the responsibility of the grantee
   and do not necessarily represent official views of the USEPA. USEPA does
   not endorse the purchase of any commercial products or services
   mentioned in the publication. APC was supported through NHLBI T-32
   HL007118.
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NR 73
TC 24
Z9 27
U1 0
U2 20
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1743-8977
J9 PART FIBRE TOXICOL
JI Part. Fibre Toxicol.
PD MAY 25
PY 2017
VL 14
AR 16
DI 10.1186/s12989-017-0196-2
PG 15
WC Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Toxicology
GA EV7SX
UT WOS:000401982800001
PM 28545487
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Partridge, CG
   Fawcett, GL
   Wang, B
   Semenkovich, CF
   Cheverud, JM
AF Partridge, Charlyn G.
   Fawcett, Gloria L.
   Wang, Bing
   Semenkovich, Clay F.
   Cheverud, James M.
TI The effect of dietary fat intake on hepatic gene expression in LG/J AND
   SM/J mice
SO BMC GENOMICS
LA English
DT Article
DE Liver; Dietary fat; Non-alcoholic fatty liver disease; NAFLD; Gene
   expression; Microarray; SM/J; LG/J
ID QUANTITATIVE TRAIT LOCI; INSULIN SENSITIVITY; ATHEROGENIC DIET;
   OXIDATIVE STRESS; LIVER-DISEASE; NONALCOHOLIC STEATOHEPATITIS; OBESE
   SUBJECTS; INFLAMMATION; ADIPOSE; MODEL
AB Background: The liver plays a major role in regulating metabolic homeostasis and is vital for nutrient metabolism. Identifying the genetic factors regulating these processes could lead to a greater understanding of how liver function responds to a high-fat diet and how that response may influence susceptibilities to obesity and metabolic syndrome. In this study we examine differences in hepatic gene expression between the LG/J and SM/J inbred mouse strains and how gene expression in these strains is affected by high-fat diet. LG/J and SM/J are known to differ in their responses to a high-fat diet for a variety of obesity-and diabetes-related traits, with the SM/J strain exhibiting a stronger phenotypic response to diet.
   Results: Dietary intake had a significant effect on gene expression in both inbred lines. Genes up-regulated by a high-fat diet were involved in biological processes such as lipid and carbohydrate metabolism; protein and amino acid metabolic processes were down regulated on a high-fat diet. A total of 259 unique transcripts exhibited a significant diet-by-strain interaction. These genes tended to be associated with immune function. In addition, genes involved in biochemical processes related to non-alcoholic fatty liver disease (NAFLD) manifested different responses to diet between the two strains. For most of these genes, SM/J had a stronger response to the high-fat diet than LG/J.
   Conclusions: These data show that dietary fat impacts gene expression levels in SM/J relative to LG/J, with SM/J exhibiting a stronger response. This supports previous data showing that SM/J has a stronger phenotypic response to high-fat diet. Based upon these findings, we suggest that SM/J and its cross with the LG/J strain provide a good model for examining non-alcoholic fatty liver disease and its role in metabolic syndrome.
C1 [Partridge, Charlyn G.; Fawcett, Gloria L.; Wang, Bing; Cheverud, James M.] Washington Univ, Dept Anat & Neurobiol, St Louis, MO 63130 USA.
   [Fawcett, Gloria L.] Baylor Coll Med, Dept Mol & Human Genet, Human Genome Sequencing Ctr, Houston, TX 77030 USA.
   [Semenkovich, Clay F.] Washington Univ, Dept Med, St Louis, MO USA.
   [Semenkovich, Clay F.] Washington Univ, Dept Cell Biol & Physiol, St Louis, MO USA.
   [Partridge, Charlyn G.] Univ Western Ontario, Dept Biol, London, ON, Canada.
   [Cheverud, James M.] Loyola Univ, Dept Biol, Chicago, IL 60626 USA.
C3 Washington University (WUSTL); Baylor College of Medicine; Washington
   University (WUSTL); Washington University (WUSTL); Western University
   (University of Western Ontario); Loyola University Chicago
RP Partridge, CG (corresponding author), Washington Univ, Dept Anat & Neurobiol, St Louis, MO 63130 USA.
EM cpartri4@uwo.ca
RI Segura-Aguilar, Juan/H-8839-2013
OI Semenkovich, Clay/0000-0003-1163-1871
FU National Institute of Health [RR015116, DK-055736]
FX This project was funded by grants obtained through the National
   Institute of Health RR015116 and DK-055736 (J M Cheverud). We would also
   like to thank Heather Lawson for assisting with statistical analysis.
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NR 62
TC 25
Z9 27
U1 0
U2 3
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1471-2164
J9 BMC GENOMICS
JI BMC Genomics
PD FEB 5
PY 2014
VL 15
AR 99
DI 10.1186/1471-2164-15-99
PG 13
WC Biotechnology & Applied Microbiology; Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Genetics & Heredity
GA AC5RC
UT WOS:000332577200001
PM 24499025
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Müller, H
   Schweitzer, N
   Jöhren, O
   Dominiak, P
   Raasch, W
AF Mueller, Helge
   Schweitzer, Nora
   Joehren, Olaf
   Dominiak, Peter
   Raasch, Walter
TI Angiotensin II stimulates the reactivity of the pituitary-adrenal axis
   in leptin-resistant Zucker rats, thereby influencing the glucose
   utilization
SO AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
LA English
DT Article
DE renin-angiotensin-aldosterone system; obesity; corticosterone;
   adrenocorticotropic hormone; diabetes
ID CORTICOTROPIN-RELEASING FACTOR; TYPE-2 DIABETES-MELLITUS; RECEPTOR
   MESSENGER-RNA; NEUROENDOCRINE ABNORMALITIES; PARAVENTRICULAR NUCLEUS;
   INSULIN SENSITIVITY; GLUCAGON-SECRETION; CIRCULATING LEPTIN; METABOLIC
   SYNDROME; OXIDATIVE STRESS
AB Angiotensin II stimulates the reactivity of the pituitary-adrenal axis in leptin-resistant Zucker rats, thereby influencing the glucose utilization. Am J Physiol Endocrinol Metab 293: E802-E810, 2007. First published June 26, 2007; doi:10.1152/ajpendo.00650.2006.- The HPA axis is hyperactive under conditions of leptin and insulin resistance as well as after ANG II administration. We hypothesized that a hyperreactivity of the HPA axis to ANG contributes to an impaired glucose utilization in obesity, since leptin resistance and an overactive renin-angiotensin-aldosterone system are features of obesity. Zucker rats were treated with ANG via subcutaneous minipumps ( 0, 0.9, and 9.0 mu g/ h; 4 wk). PA axis reactivity and glucose homeostasis were characterized after CRH treatment and during an oral glucose tolerance test (OGTT). The elevated plasma profile of corticosterone after CRH stimulation in saline-treated OZR compared with LZR confirmed that the sensitization of the PA axis depended on leptin resistance. Irrespective of the rat strain, circulating ANG levels and blood pressure were selectively increased after administration of 9 mu g/ h ANG (high ANG). Only high ANG induced an elevation of the corticosterone and glucose response after CRH stimulation in OZR but did not affect the ACTH secretion. During OGTT, corticosterone and consequently glucose increased in OZR after high ANG, whereas the insulin secretion was decreased. In the adrenal glands of OZR, AT(1A) receptor mRNA levels increased after high ANG. We conclude that the impairment of glucose utilization after ANG stimulation is potentiated in leptin-resistant rats as a result of a hyperreactive PA axis, thereby confirming the functional importance of a dysregulation within the HPA axis in metabolic syndrome or obesity. The ACTH-independent stimulation of corticosterone release and the selective increase of AT1A receptor mRNA in the adrenals of OZR indicated a sensitization of adrenals toward ANG, causing a stimulation of the PA axis.
C1 Univ Clin Schleswig Holstein, Inst Expt & Clin Pharmacol & Toxicol, D-23538 Lubeck, Germany.
C3 University of Kiel; Schleswig Holstein University Hospital
RP Raasch, W (corresponding author), Univ Clin Schleswig Holstein, Inst Expt & Clin Pharmacol & Toxicol, Ratzeburger Allee 160, D-23538 Lubeck, Germany.
EM raasch@medinf.mu-luebeck.de
RI Jöhren, Olaf/G-6967-2011; Raasch, Walter/AAR-1165-2020
OI Johren, Olaf/0000-0002-0532-5133; Muller-Fielitz,
   Helge/0000-0003-2815-4426
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NR 72
TC 26
Z9 28
U1 0
U2 3
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0193-1849
J9 AM J PHYSIOL-ENDOC M
JI Am. J. Physiol.-Endocrinol. Metab.
PD SEP
PY 2007
VL 293
IS 3
BP E802
EP E810
DI 10.1152/ajpendo.00650.2006
PG 9
WC Endocrinology & Metabolism; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Physiology
GA 208YJ
UT WOS:000249354800021
PM 17595220
DA 2025-06-11
ER

PT J
AU Leboyer, M
   Soreca, I
   Scott, J
   Frye, M
   Henry, C
   Tamouza, R
   Kupfer, DJ
AF Leboyer, Marion
   Soreca, Isabella
   Scott, Jan
   Frye, Mark
   Henry, Chantal
   Tamouza, Ryad
   Kupfer, David J.
TI Can bipolar disorder be viewed as a multi-system inflammatory disease?
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Review
DE Bipolar disorder; Cardiovascular disease; Mortality; Inflammation;
   Staging; Prevention
ID CARDIOVASCULAR RISK-FACTORS; CORONARY-HEART-DISEASE; C-REACTIVE PROTEIN;
   METABOLIC SYNDROME; GENETIC VULNERABILITY; MEDICAL CONDITIONS;
   DIABETES-MELLITUS; CYTOKINE LEVELS; MORTALITY; SCHIZOPHRENIA
AB Background: Patients with bipolar disorder are known to be at high risk of premature death. Comorbid cardio-vascular diseases are a leading cause of excess mortality, well above the risk associated with suicide. In this review, we explore comorbid medical disorders, highlighting evidence that bipolar disorder can be effectively conceptualized as a multi-systemic inflammatory disease.
   Methods: We conducted a systematic PubMed search of all English-language articles recently published with bipolar disorder cross-referenced with the following terms: mortality and morbidity, cardio-vascular, diabetes, obesity, metabolic syndrome, inflammation, auto-antibody, retro-virus, stress, sleep and circadian rhythm.
   Results: Evidence gathered so far suggests that the multi-system involvement is present from the early stages, and therefore requires proactive screening and diagnostic procedures, as well as comprehensive treatment to reduce progression and premature mortality. Exploring the biological pathways that could account for the observed link show that dysregulated inflammatory background could be a common factor underlying cardio-vascular and bipolar disorders. Viewing bipolar disorder as a multi-system disorder should help us to re-conceptualize disorders of the mind as "disorders of the brain and the body".
   Limitations: The current literature substantially lacks longitudinal and mechanistic studies, as well as comparison studies to explore the magnitude of the medical burden in bipolar disorder compared to major mood disorders as well as psychotic disorders. It is also necessary to look for subgroups of bipolar disorder based on their rates of comorbid disorders.
   Conclusions: Comorbid medical illnesses in bipolar disorder might be viewed not only as the consequence of health behaviors and of psychotropic medications, but rather as an early manifestation of a multi-systemic disorder. Medical monitoring is thus a critical component of case assessment. Exploring common biological pathways of inflammation should help biomarkers discovery, ultimately leading to innovative diagnostic tools, new methods of prevention and personalized treatments. (c) 2012 Elsevier B.V. All rights reserved.
C1 [Leboyer, Marion; Scott, Jan; Henry, Chantal] Univ Paris Est, INSERM U955, FondaMental Fdn, Fdn Cooperat Sci,Grp Hosp Mondor,AP HP, F-94000 Creteil, France.
   [Leboyer, Marion; Soreca, Isabella; Henry, Chantal; Kupfer, David J.] Univ Pittsburgh, Sch Med, Dept Psychiat, Pittsburgh, PA 15260 USA.
   [Scott, Jan] Newcastle Univ, Inst Neurosci, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England.
   [Frye, Mark] Mayo Clin, Dept Psychiat, Rochester, MN USA.
   [Tamouza, Ryad] Hop St Louis, Immunol & Histocompatibil Dept, F-75010 Paris, France.
   [Tamouza, Ryad] Hop St Louis, INSERM, U940, F-75010 Paris, France.
C3 Institut National de la Sante et de la Recherche Medicale (Inserm);
   Assistance Publique Hopitaux Paris (APHP); Universite
   Paris-Est-Creteil-Val-de-Marne (UPEC); Hopital Universitaire
   Henri-Mondor - APHP; Pennsylvania Commonwealth System of Higher
   Education (PCSHE); University of Pittsburgh; Newcastle University - UK;
   Mayo Clinic; Assistance Publique Hopitaux Paris (APHP); Universite Paris
   Cite; Hopital Universitaire Saint-Louis - APHP; Assistance Publique
   Hopitaux Paris (APHP); Universite Paris Cite; Hopital Universitaire
   Saint-Louis - APHP; Institut National de la Sante et de la Recherche
   Medicale (Inserm)
RP Leboyer, M (corresponding author), Hop Albert Chenevier, 40 Rue Mesly, F-94000 Creteil, France.
EM Marion.leboyer@inserm.fr
RI Tamouza, Ryad/AGQ-6644-2022; Leboyer, Marion/AAW-3648-2021; Scott,
   Jan/F-2966-2010
OI Scott, Jan/0000-0002-7203-8601; LEBOYER, Marion/0000-0001-5473-3697
FU NIDA NIH HHS [DA027508-03, R01 DA027508] Funding Source: Medline; NIMH
   NIH HHS [MH081003, R01 MH081003] Funding Source: Medline
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NR 101
TC 346
Z9 375
U1 0
U2 90
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD DEC 1
PY 2012
VL 141
IS 1
BP 1
EP 10
DI 10.1016/j.jad.2011.12.049
PG 10
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA 011EV
UT WOS:000309148500001
PM 22497876
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Truong, TM
   Fumie, N
   Chuyen, NV
AF Truong Tuyet Mai
   Fumie, Nagashima
   Chuyen, Nguyen Van
TI ANTIOXIDANT ACTIVITIES AND HYPOLIPIDEMIC EFFECTS OF AN AQUEOUS EXTRACT
   FROM FLOWER BUDS OF CLEISTOCALYX OPERCULATUS (ROXB.) MERR. AND
   PERRY
SO JOURNAL OF FOOD BIOCHEMISTRY
LA English
DT Article
ID OXIDATIVE STRESS; LIPID-PEROXIDATION; PANCREATIC LIPASE; ALDOSE
   REDUCTASE; TEA POLYPHENOLS; IN-VITRO; FLAVONOIDS; RAT; GLUTATHIONE;
   INHIBITION
AB The antioxidant activities and hypolipidemic effects of aqueous extract from Cleistocalyx operculatus flower buds (COB) (Roxb.) Merr. and Perry, a commonly used material for drink preparation in Vietnam, were investigated in vitro and in diabetic rats. In vitro, the aqueous extract of COB which has highest phenolic and flavonoid contents showed a strong antioxidant effect and highest pancreatic lipase inhibitory activity when compared with green tea and guava leaf extracts. Oral administration of aqueous extract from COB (500 mg/kg body weight/day) on streptozotocin-induced diabetic rats for 8 weeks resulted in significant reduction in the levels of glucose, total cholesterol and triglyceride in plasma as well as the concentration of glucose and sorbitol in the lens. In addition, COB showed significant recovery in the activities of antioxidant enzymes (superoxide dismutase, glutathione S-transferase) and glutathione level in liver with markedly decrease in the lipid peroxide level in liver and lens of the COB-treated diabetic rats. These results indicated that COB showed antioxidant activities, prevention of sorbitol accumulation in lens and hypolipidemic effects in addition to its antidiabetic effects and may be considered as a promising material for the prevention of diabetic complications and metabolic syndrome.
   PRACTICAL APPLICATIONS
   In recent years, research on traditional medicinal plants for the management of diabetes has attracted the interest of medical scientists. A suitable plant material for antidiabetes and prevention of diabetic complications should possess various biological components, such as antihyperglycemia, antioxidant activities and antihyperlipidemia, without side effects. In this study, the aqueous extract from Cleistocalyx operculatus flower buds (COB) with high polyphenolic and flavonoid content has shown beneficial biological functions in vitro and in diabetic rats, including antioxidant activity, hypolipidemic and hypoglycemic effects.
   The results of our study suggest that COB might have a potential role in the management of the prediabetic state and the prevention of diabetic complications. Therefore, there is the possibility for the development of C. operculatus as a beverage for the prevention of diabetes, as well as the prevention of the metabolic syndrome.
C1 [Truong Tuyet Mai; Fumie, Nagashima; Chuyen, Nguyen Van] Japan Womens Univ, Dept Food & Nutr, Bunkyo Ku, Tokyo 1128681, Japan.
   [Truong Tuyet Mai] Natl Inst Nutr, Hanoi, Vietnam.
C3 Japan Womens University
RP Chuyen, NV (corresponding author), Japan Womens Univ, Dept Food & Nutr, Bunkyo Ku, 2-8-1 Mejirodai, Tokyo 1128681, Japan.
EM chuyen_nguyen63@fc.jwu.ac.jp
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NR 37
TC 21
Z9 21
U1 2
U2 12
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0145-8884
EI 1745-4514
J9 J FOOD BIOCHEM
JI J. Food Biochem.
PD DEC
PY 2009
VL 33
IS 6
BP 790
EP 807
DI 10.1111/j.1745-4514.2009.00251.x
PG 18
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA 530HD
UT WOS:000272579100003
DA 2025-06-11
ER

PT J
AU Huang, LL
   Dou, DM
   Liu, N
   Wang, XX
   Fu, LY
   Wu, X
   Wang, PX
AF Huang, Ling Ling
   Dou, Dong-Mei
   Liu, Nan
   Wang, Xiao Xiao
   Fu, Li-Ying
   Wu, Xiao
   Wang, Peixi
TI Association of erythrocyte parameters with metabolic syndrome in the
   Pearl River Delta region of China: a cross sectional study
SO BMJ OPEN
LA English
DT Article
ID COMMUNITY-DWELLING PERSONS; CELL DISTRIBUTION WIDTH; C-REACTIVE PROTEIN;
   HEMATOLOGICAL PARAMETERS; INSULIN-RESISTANCE; ENDOTHELIAL DYSFUNCTION;
   CARDIOVASCULAR RISK; SYNDROME COMPONENTS; OXIDATIVE STRESS;
   GROWTH-FACTOR
AB Objective Increasing studies have reported that erythrocyte parameters, including red blood cells (RBCs), haematocrit (HCT), haemoglobin (Hb) and red blood cell distribution width (RDW), are associated with metabolic syndrome (MetS) in adults worldwide. However, the association, stratified by sex, remains to be elucidated, particularly in the Pearl River Delta region of China. Therefore, our aim was to explore the association of erythrocyte parameters with MetS, stratified by sex, in the Pearl River Delta region of China.
   Methods In this cross sectional study, 2161 men and 2511 women were enrolled. MetS was diagnosed using a modified version of the Adult Treatment Panel III criteria. Logistic regression analyses were performed to calculate adjusted ORs of erythrocyte parameters associated with MetS stratified by sex.
   Results The prevalence of MetS was higher in women than in men (35.2%vs26.7%). RBC, HCT, Hb and RDW values increased linearly with the number of MetS components from 0 to 5 identified in both men and women. Among men, the ORs of MetS risk increased across the tertiles of Hb (Q2: OR=1.921, 95% Cl=1.170 to 3.151; Q3: OR=1.992, 95%Cl=1.198 to 3.312). Men in the highest tertiles of RDW had a 2.752-fold increased risk of suffering from MetS compared with those in the reference group. Among women, the ORs of MetS risk also increased across the tertiles of Hb (Q2: OR=1.538, 95%Cl=1.008 to 2.348; 03: OR=1.665, 95%Cl=1.075 to 2.578). Women in the highest tertiles of RBC had a 1.718-fold increased risk of experiencing MetS compared with those in the reference group.
   Conclusions MetS was more prevalent in women than in men. The association between erythrocyte parameters and MetS differed between the sexes. RBC and Hb were identified as risk factors for MetS in women and Hb and RDW as risk factors in men.
C1 [Huang, Ling Ling; Dou, Dong-Mei; Wang, Xiao Xiao; Fu, Li-Ying; Wu, Xiao; Wang, Peixi] Henan Univ, Inst Chron Dis Risks Assessment, Kaifeng, Peoples R China.
   [Liu, Nan; Wang, Peixi] Guangzhou Med Univ, Sch Publ Hlth, Guangzhou, Guangdong, Peoples R China.
C3 Henan University; Guangzhou Medical University
RP Wang, PX (corresponding author), Henan Univ, Inst Chron Dis Risks Assessment, Kaifeng, Peoples R China.; Wang, PX (corresponding author), Guangzhou Med Univ, Sch Publ Hlth, Guangzhou, Guangdong, Peoples R China.
EM peixi001@163.com
RI Huang, LingLing/JHT-1907-2023; Liu, Nan/W-1842-2019
OI Liu, Nan/0000-0002-8895-3169
FU Guangzhou 121 Talents Programme [GZRSH-2014-2048]; Science and
   Technology Program of Guangzhou [201607010136, 201510010109]; National
   Science Foundation of China [81402716]
FX This study was supported by the Guangzhou 121 Talents Programme
   (GZRSH-2014-2048), the Science and Technology Program of Guangzhou
   (201607010136, 201510010109) and the National Science Foundation of
   China (81402716).
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NR 48
TC 19
Z9 19
U1 0
U2 6
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2044-6055
J9 BMJ OPEN
JI BMJ Open
PD JAN
PY 2018
VL 8
IS 1
AR e019792
DI 10.1136/bmjopen-2017-019792
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA GF2BO
UT WOS:000431743500195
PM 29326194
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Caricilli, AM
   Picardi, PK
   de Abreu, LL
   Ueno, M
   Prada, PO
   Ropelle, ER
   Hirabara, SM
   Castoldi, A
   Vieira, P
   Camara, NOS
   Curi, R
   Carvalheira, JB
   Saad, MJA
AF Caricilli, Andrea M.
   Picardi, Paty K.
   de Abreu, Lelia L.
   Ueno, Mirian
   Prada, Patricia O.
   Ropelle, Eduardo R.
   Hirabara, Sandro Massao
   Castoldi, Angela
   Vieira, Pedro
   Camara, Niels O. S.
   Curi, Rui
   Carvalheira, Jose B.
   Saad, Mario J. A.
TI RETRACTED: Gut Microbiota Is a Key Modulator of Insulin Resistance in
   TLR 2 Knockout Mice (Retracted Article)
SO PLOS BIOLOGY
LA English
DT Article; Retracted Publication
ID DIET-INDUCED OBESITY; REGULATORY T-CELLS; TOLL-LIKE RECEPTOR-2;
   INTESTINAL PERMEABILITY; BACTERIAL OVERGROWTH; INDUCED INFLAMMATION;
   METABOLIC SYNDROME; GLUCOSE-TOLERANCE; WALL COMPONENTS; ADIPOSE-TISSUE
AB Environmental factors and host genetics interact to control the gut microbiota, which may have a role in the development of obesity and insulin resistance. TLR2-deficient mice, under germ-free conditions, are protected from diet-induced insulin resistance. It is possible that the presence of gut microbiota could reverse the phenotype of an animal, inducing insulin resistance in an animal genetically determined to have increased insulin sensitivity, such as the TLR2 KO mice. In the present study, we investigated the influence of gut microbiota on metabolic parameters, glucose tolerance, insulin sensitivity, and signaling of TLR2-deficient mice. We investigated the gut microbiota (by metagenomics), the metabolic characteristics, and insulin signaling in TLR2 knockout (KO) mice in a non-germ free facility. Results showed that the loss of TLR2 in conventionalized mice results in a phenotype reminiscent of metabolic syndrome, characterized by differences in the gut microbiota, with a 3-fold increase in Firmicutes and a slight increase in Bacteroidetes compared with controls. These changes in gut microbiota were accompanied by an increase in LPS absorption, subclinical inflammation, insulin resistance, glucose intolerance, and later, obesity. In addition, this sequence of events was reproduced in WT mice by microbiota transplantation and was also reversed by antibiotics. At the molecular level the mechanism was unique, with activation of TLR4 associated with ER stress and JNK activation, but no activation of the IKK beta-I kappa B-NF kappa B pathway. Our data also showed that in TLR2 KO mice there was a reduction in regulatory T cell in visceral fat, suggesting that this modulation may also contribute to the insulin resistance of these animals. Our results emphasize the role of microbiota in the complex network of molecular and cellular interactions that link genotype to phenotype and have potential implications for common human disorders involving obesity, diabetes, and even other immunological disorders.
C1 [Caricilli, Andrea M.; Picardi, Paty K.; Ueno, Mirian; Prada, Patricia O.; Ropelle, Eduardo R.; Carvalheira, Jose B.; Saad, Mario J. A.] Univ Estadual Campinas, Dept Internal Med, Campinas, SP, Brazil.
   [de Abreu, Lelia L.] Univ Estadual Campinas, Dept Nursing, Campinas, SP, Brazil.
   [Hirabara, Sandro Massao; Curi, Rui] Univ Sao Paulo, Inst Biomed Sci, Dept Physiol & Biophys, Sao Paulo, Brazil.
   [Castoldi, Angela; Vieira, Pedro; Camara, Niels O. S.] Univ Sao Paulo, Inst Biomed Sci, Dept Immunol, Sao Paulo, Brazil.
C3 Universidade Estadual de Campinas; Universidade Estadual de Campinas;
   Universidade de Sao Paulo; Institute Biomed Science, University Sao
   Paulo; Universidade de Sao Paulo; Institute Biomed Science, University
   Sao Paulo
RP Caricilli, AM (corresponding author), Univ Estadual Campinas, Dept Internal Med, Campinas, SP, Brazil.
EM msaad@fcm.unicamp.br
RI Saad, Mario/ABD-8262-2020; Caricilli, Andrea/C-6294-2012; Castoldi,
   Angela/K-1889-2015; Carvalheira, Jose/H-8405-2012; Curi,
   Rui/C-9351-2012; Prada, Patricia/R-6269-2018; Olsen Saraiva Camara,
   Niels/AAX-3269-2020; Ropelle, Eduardo/C-3977-2012; Hirabara, Sandro
   Massao/C-4014-2012; Vieira, Pedro/C-8701-2014
OI Olsen Saraiva Camara, Niels/0000-0001-5436-1248; Ropelle,
   Eduardo/0000-0003-1655-9557; Hirabara, Sandro
   Massao/0000-0002-7392-0444; Vieira, Pedro/0000-0002-8263-786X; Castoldi,
   Angela/0000-0002-8434-7989
FU Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP); Conselho
   Nacional de desenvolvimento cientifico e tecnologico (CNPq)
FX This study was supported by grants from Fundacao de Amparo a Pesquisa do
   Estado de Sao Paulo (FAPESP) and Conselho Nacional de desenvolvimento
   cientifico e tecnologico (CNPq). The funders had no role in study
   design, data collection and analysis, decision to publish, or
   preparation of the manuscript.
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NR 76
TC 205
Z9 223
U1 0
U2 95
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1544-9173
EI 1545-7885
J9 PLOS BIOL
JI PLoS. Biol.
PD DEC
PY 2011
VL 9
IS 12
AR e1001212
DI 10.1371/journal.pbio.1001212
PG 21
WC Biochemistry & Molecular Biology; Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics
GA 870MH
UT WOS:000298673000003
PM 22162948
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Alves-Costa, S
   Rodrigues, FA
   Ferraro, AA
   Nascimento, GG
   Leite, FRM
   Souza, BF
   Ribeiro, CCC
AF Alves-Costa, S.
   Rodrigues, F. A.
   Ferraro, A. A.
   Nascimento, G. G.
   Leite, F. R. M.
   Souza, B. F.
   Ribeiro, C. C. C.
TI Caries Is the Hub of a Complex Network of Chronic Diseases across the
   Life Decades
SO JOURNAL OF DENTAL RESEARCH
LA English
DT Article; Early Access
DE noncommunicable diseases; oral health; obesity; metabolic syndrome;
   dyslipidemia; prediabetes
ID INSULIN-RESISTANCE; HEALTH
AB Caries precedes periodontitis; both may predict fatal noncommunicable diseases (NCDs) decades in advance. However, the complex network of relationships between these and other NCDs remains unclear. Understanding the intricate nonlinear connections among NCDs from the early life stages holds profound significance for public health management strategies to prevent NCDs. Accordingly, we modeled the connections among NCDs and identified the underlying patterns in the US population from childhood to elderhood. Indicators of metabolic risks, diabetes, and cancer, as well as cardiovascular, autoimmune, mental, respiratory, and oral diseases, were collected from National Health and Nutrition Examination Survey data (2011-2012 and 2013-2014 cycles), encompassing 4 age groups of Americans aged 1 to >= 60 y. Diseases were represented as nodes in the complex network analysis, and edges indicated their co-occurrences. To characterize the networks, we computed degree, betweenness, eigenvector, local transitivity, assortative mixing, Shannon entropy, and cluster coefficients. Caries was the central hub in all models. Caries and obesity were linked since the first years of life, and with age, new diseases became connected, increasing network complexity with Shannon entropy from -2.79 to -4.07. Depression plays an essential role in adult life; however, episodes of forgetting and mental confusion surpass depression's significance in elderhood. The centrality of diabetes, cardiovascular disease, and cancer increases with age, peaking at >= 60 y, with diabetes being the most prominent. All groups had coefficients indicating that NCDs were highly connected, with cluster coefficients of 0.85 to 0.98 and assortativity mixing of -0.23 to -0.06. Caries was the central element over the decades, with the other diseases orbiting around it. It was mainly linked to overweight/obesity from early childhood. Integrated strategies targeting shared risk factors for caries and obesity can boost childhood health and potentially affect the development of other NCDs later.
C1 [Alves-Costa, S.; Ribeiro, C. C. C.] Univ Fed Maranhao, Grad Program Dent, Sao Luis, Brazil.
   [Rodrigues, F. A.] Univ Sao Paulo, Inst Math & Comp Sci, Sao Carlos, Brazil.
   [Ferraro, A. A.] Univ Sao Paulo, Fac Med, Dept Pediat, Sao Paulo, Brazil.
   [Nascimento, G. G.; Leite, F. R. M.] Natl Dent Ctr Singapore, Natl Dent Res Inst Singapore, Singapore, Singapore.
   [Nascimento, G. G.; Leite, F. R. M.] Duke NUS Med Sch, Oral Hlth Acad Clin Programme, Singapore, Singapore.
   [Souza, B. F.] Univ Fed Maranhao, Grad Program Comp Sci, Sao Luis, Brazil.
   [Souza, B. F.; Ribeiro, C. C. C.] Univ Fed Maranhao, Grad Program Publ Hlth, Sao Luis, Brazil.
C3 Universidade Federal do Maranhao; Universidade de Sao Paulo;
   Universidade de Sao Paulo; Universidade Federal de Sao Paulo (UNIFESP);
   National University of Singapore; Universidade Federal do Maranhao;
   Universidade Federal do Maranhao
RP Ribeiro, CCC (corresponding author), Univ Fed Maranhao, Av Portugueses 1966, BR-65085580 Sao Luis, MA, Brazil.
EM cecilia.ribeiro@ufma.br
RI Leite, Fabio/G-5709-2013; Alves-Costa, Silas/AGK-5745-2022; Nascimento,
   Gustavo/AAT-9003-2020
OI Nascimento, Gustavo/0000-0002-4288-6300
FU Coordination for the Improvement of Higher Education Personnel-Brazil
   (CAPES) [001, 88887.637402/2021-00]; PROCAD Amazpnia
   [88881.719704/2022-01]; Brazilian Research Council (CNPq)
FX The authors disclosed receipt of the following financial support for the
   research, authorship, and/or publication of this article: S.A.C. was
   supported by a PhD scholarship from the Coordination for the Improvement
   of Higher Education Personnel-Brazil (CAPES finance code 001, Brazil)
   through the PGPG-Amazpnia Legal (88887.637402/2021-00) and by a Sandwich
   PhD scholarship from the PROCAD Amazpnia (88881.719704/2022-01).
   C.C.C.R. received a Research Productivity Scholarship from the Brazilian
   Research Council (CNPq).
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NR 39
TC 0
Z9 0
U1 4
U2 4
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0022-0345
EI 1544-0591
J9 J DENT RES
JI J. Dent. Res.
PD 2025 APR 27
PY 2025
DI 10.1177/00220345251317487
EA APR 2025
PG 9
WC Dentistry, Oral Surgery & Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dentistry, Oral Surgery & Medicine
GA 2AG5S
UT WOS:001477863900001
PM 40289443
DA 2025-06-11
ER

PT J
AU Tamayo, JM
   Mazzotti, G
   Tohen, M
   Gattaz, WF
   Zapata, R
   Castillo, JJ
   Fahrer, RD
   Gonzalez-Pinto, AM
   Vieta, E
   Azorin, JM
   Brown, E
   Brunner, E
   Rovner, J
   Bonett-Perrin, E
   Baker, RW
AF Tamayo, Jorge M.
   Mazzotti, Guido
   Tohen, Mauricio
   Gattaz, Wagner F.
   Zapata, Ricardo
   Castillo, Jose J.
   Fahrer, Rodolfo D.
   Gonzalez-Pinto, Ana M.
   Vieta, Eduard
   Azorin, Jean M.
   Brown, Eileen
   Brunner, Elizabeth
   Rovner, Jorge
   Bonett-Perrin, Elena
   Baker, Robert W.
TI Outcomes for Latin American versus white patients suffering from acute
   mania in a randomized, double-blind trial comparing olanzapine and
   haloperidol
SO JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
LA English
DT Article
ID 3RD NATIONAL-HEALTH; D2-DOPAMINE RECEPTOR OCCUPANCY; NUTRITION
   EXAMINATION SURVEY; METABOLIC SYNDROME; DIABETES-MELLITUS; MAJOR
   DEPRESSION; BIPOLAR MANIA; RATING-SCALE; US ADULTS; PREVALENCE
AB Data from a published double-blind randomized trial comparing olanzapine versus haloperidol in acute mania were used to address the response and tolerability of Latin American patients. Primary efficacy end point was the remission rate (Young Mania Rating Scale score <= 12 and Hamilton Depression Rating Scale score of <= 8). Patients were analyzed on an intent-to-treat basis. The mean modal doses (milligrams per day) were similar in Latin American (OL) (14.2; n = 51) and white (OC) (15.1; n = 120) patients treated with olanzapine, and in Latin American (HL) (7.1; n = 48) and white (HC) (8.5; n = 113) patients treated with haloperidol. At week 6, remission rates were similar among the OL and HL patients (64.7% vs. 68.8%) but were higher in the OC than in HC (49.2% vs. 32.7%; P = 0.012). Significantly more HL than OL patients experienced extrapyramidal symptoms such as akathisia and tremor. Tremor was significantly higher in HL than in HC patients, whereas a significant increase in the Barnes Akathisia Scale and Abnormal Involuntary Movement Scale scores was observed in HC versus HL. Somnolence and weight gain were significantly higher in OL than in OC patients, and more OL and OC patients experienced weight gain in comparison with the HL and HC groups, respectively. The incidence of nonfasting glucose levels above normal levels did not statistically differ between groups. In conclusion, in contrast to our findings among white patients, the Latin American patients who have acute mania did not differ in overall response to olanzapine or haloperidol. The pattern of adverse events differed between treatment groups. Prospective clinical trials in Latin American bipolar populations are justified.
C1 CES Univ, Dept Psychiat, Medellin, Colombia.
   Natl Inst Mental Hlth Honorio Delgado Hideyo Nogu, Lima, Peru.
   Univ Peruana Cayetano Heredia, Dept Psychiat, Lima, Peru.
   Lilly Res Labs, Indianapolis, IN USA.
   Harvard Univ, Sch Med, McLean Hosp, Boston, MA 02115 USA.
   Univ Sao Paulo, Fac Med, Dept Psychiat, Neurosci Lab, Sao Paulo, Brazil.
   Univ Sao Paulo, Fac Med, Inst Psychiat, Neurosci Lab, Sao Paulo, Brazil.
   SSA, CECOSAM, Monterrey, Mexico.
   Hosp Psychiat, Monterrey, Mexico.
   Univ Buenos Aires, Dept Mental Hlth, Sch Med, Univ Hosp, Buenos Aires, DF, Argentina.
   Santiago Apostol Hosp, Dept Psychiat, Osakidetza Mental Hlth Syst, Vitoria, Spain.
   Univ Barcelona, IDIBAPS, Hosp Clin Barcelona, Program Bipolar Disorders, Barcelona, Spain.
   Hop St Marquerite, Serv Psychiat Adulte, Marseille, France.
   Univ Buenos Aires, Dept Psychiat, Buenos Aires, DF, Argentina.
   Univ Puerto Rico, Dept Psychiat, San Juan, PR 00936 USA.
C3 Universidad Peruana Cayetano Heredia; Eli Lilly; Lilly Research
   Laboratories; Harvard University; Harvard University Medical Affiliates;
   McLean Hospital; Harvard Medical School; Universidade de Sao Paulo;
   Universidade de Sao Paulo; University of Buenos Aires; University of
   Buenos Aires Hospital; University of Barcelona; Hospital Clinic de
   Barcelona; IDIBAPS; Aix-Marseille Universite; Assistance
   Publique-Hopitaux de Marseille; University of Buenos Aires; University
   of Puerto Rico
RP Tamayo, JM (corresponding author), BMSS, Tore Intermed Calle 7 42-197, Medellin 1619, Colombia.
EM tamayojm@gmail.com
RI Vieta, Eduard/Y-2919-2019; Tamayo, Jorge/ABF-2309-2021; Gattaz,
   Wagner/C-4456-2012; Torres, Miguel/HZK-8113-2023; Vieta,
   Eduard/I-6330-2013
OI Vieta, Eduard/0000-0002-0548-0053; Tamayo, Jorge/0000-0003-1452-7420;
   Gonzalez-Pinto, Ana Maria/0000-0002-2568-5179
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NR 54
TC 18
Z9 18
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0271-0749
EI 1533-712X
J9 J CLIN PSYCHOPHARM
JI J. Clin. Psychopharmacol.
PD APR
PY 2007
VL 27
IS 2
BP 126
EP 134
DI 10.1097/JCP.0b013e318033bd4a
PG 9
WC Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Psychiatry
GA 148SG
UT WOS:000245094300002
PM 17414234
DA 2025-06-11
ER

PT J
AU Dong, RX
   Pan, JJ
   Zhao, GS
   Zhao, QY
   Wang, SQ
   Li, N
   Song, LJ
   Huang, XQ
   Miao, SX
   Ying, JH
   Wu, FY
   Wang, DX
   Cheng, KJ
   Granato, D
   Ban, QY
AF Dong, Ruixia
   Pan, Junjie
   Zhao, Guangshan
   Zhao, Qiuyan
   Wang, Shiqiong
   Li, Ning
   Song, Lianjun
   Huang, Xianqing
   Miao, Shuxing
   Ying, Junhui
   Wu, Fangying
   Wang, Dongxu
   Cheng, Kejun
   Granato, Daniel
   Ban, Qiuyan
TI Antioxidant, antihyperglycemic, and antihyperlipidemic properties of
   Chimonanthus salicifolius S. Y. Hu leaves in experimental
   animals: modulation of thioredoxin and glutathione systems, renal water
   reabsorption, and gut microbiota
SO FRONTIERS IN NUTRITION
LA English
DT Article
DE Chimonanthus salicifolius S; Y; Hu leaves; antioxidant; metabolic
   syndrome; renal water reabsorption; gut microbiota
ID HEME OXYGENASE-1 EXPRESSION; KINASE-C-ALPHA; UREA TRANSPORTER; HIGH-FAT;
   OXIDATIVE DAMAGE; IN-VITRO; MICE; AQUAPORIN-2; CELLS; NRF2
AB IntroductionExcessive calorie intake and physical inactivity have dramatically increased nutrient overload-associated disease, becoming a global public health issue. Chimonanthus salicifolius S. Y. Hu (CHI) is a homology plant of food and medicine in China and shows several health benefits. MethodsThis work investigated the antioxidant activity, the alleviating effects, and the mechanism of action on diabetes and hyperlipidemia of CHI leaves. Results and discussionResults showed that CHI leaves infusion displayed in vitro antioxidant activity measured by ABTS and ferric reducing antioxidant power methods. In wild-type Kunming mice, CHI leaves infusion consumption activated the hepatic antioxidant enzymes, including glutathione reductase, glutathione S-transferase, glutathione peroxidase and thioredoxin reductase as well as thioredoxin reductase 1. In alloxan-induced type 1 diabetic mice, CHI leaves infusion ameliorated diabetic symptoms, including polyuria, polydipsia, polyphagia and hyperglycemia, in a dose-dependent and time-course manners. The mechanism involved CHI leaves up-regulating renal water reabsorption associated protein - urine transporter A1-and promoting the trafficking of urine transporter A1 and aquaporin 2 to the apical plasma membrane. Despite this, in high-fat diet-induced hyperlipidemic golden hamsters, CHI leaves powder did not significantly effect on hyperlipidemia and body weight gain. This might be attributed to CHI leaves powder increasing the calorie intake. Interestingly, we found that CHI leaves extract containing a lower dose of total flavonoid than CHI leaves powder pronouncedly reduced the levels of total cholesterol, triglyceride, and low-density lipoprotein cholesterol in serum in golden hamsters fed a high-fat diet. Furthermore, CHI leaves extract elevated the diversity of gut microbiota and the abundance of Bifidobacterium and Ruminococcaceae_UCG-014. It also decreased the abundance of Lactobacillus at the genus level in golden hamsters fed a high-fat diet. Overall, CHI leaves benefit oxidative stress prevention and metabolic syndrome amelioration in vivo.
C1 [Dong, Ruixia; Miao, Shuxing] Jinling Inst Technol, Coll Hort, Nanjing, Peoples R China.
   [Dong, Ruixia; Ying, Junhui; Wu, Fangying] Coll Forestry Sci & Technol, Lishui Vocat & Tech Coll, Lishui, Peoples R China.
   [Dong, Ruixia; Zhao, Guangshan; Wang, Dongxu] Anhui Agr Univ, Sch Tea & Food Sci & Technol, State Key Lab Tea Plant Biol & Utilizat, Hefei, Peoples R China.
   [Pan, Junjie; Cheng, Kejun] Lishui Inst Agr & Forestry Sci, Chem Biol Ctr, Lishui, Peoples R China.
   [Zhao, Guangshan; Zhao, Qiuyan; Wang, Shiqiong; Li, Ning; Song, Lianjun; Huang, Xianqing] Henan Agr Univ, Coll Food Sci & Technol, Innovat Team Food Nutr & Safety Control, Zhengzhou, Peoples R China.
   [Wang, Dongxu] Jiangsu Univ Sci & Technol, Sch Grain Sci & Technol, Zhenjiang, Peoples R China.
   [Granato, Daniel] Univ Limerick, Fac Sci & Engn, Dept Biol Sci, Bioact & Applicat Lab, Limerick, Ireland.
   [Ban, Qiuyan] Henan Agr Univ, Coll Hort, Dept Tea Sci, Zhengzhou, Peoples R China.
C3 Jinling Institute of Technology; Lishui Vocational Technical College;
   Anhui Agricultural University; Henan Agricultural University; Jiangsu
   University of Science & Technology; University of Limerick; Henan
   Agricultural University
RP Zhao, GS; Wang, DX (corresponding author), Anhui Agr Univ, Sch Tea & Food Sci & Technol, State Key Lab Tea Plant Biol & Utilizat, Hefei, Peoples R China.; Cheng, KJ (corresponding author), Lishui Inst Agr & Forestry Sci, Chem Biol Ctr, Lishui, Peoples R China.; Zhao, GS (corresponding author), Henan Agr Univ, Coll Food Sci & Technol, Innovat Team Food Nutr & Safety Control, Zhengzhou, Peoples R China.; Wang, DX (corresponding author), Jiangsu Univ Sci & Technol, Sch Grain Sci & Technol, Zhenjiang, Peoples R China.; Granato, D (corresponding author), Univ Limerick, Fac Sci & Engn, Dept Biol Sci, Bioact & Applicat Lab, Limerick, Ireland.; Ban, QY (corresponding author), Henan Agr Univ, Coll Hort, Dept Tea Sci, Zhengzhou, Peoples R China.
EM zgs2015@yeah.net; wdx@just.edu.cn; chengkejun@gmail.com;
   daniel.granato@ul.ie; banqiuyan717@163.com
RI Chen, Jinyan/JJF-7875-2023; wu, fang/KYO-8139-2024; Zhao, Qiu
   yan/HTR-7730-2023; huang, xianqing/ABA-4371-2021; Granato,
   Daniel/AAC-6151-2019
OI Wang, Dongxu/0000-0001-7377-6190; Granato, Daniel/0000-0002-4533-1597;
   Cheng, Kejun/0000-0002-1936-9129; Zhao, Guangshan/0000-0002-6517-2597
FU Zhejiang Provincial Basic Public Welfare Research Program Project
   [LGF20H280007]; Open Fund of State Key Laboratory of Tea Plant Biology
   and Utilization [SKLTOF20200127, SKLT0F20200108]; Doctoral Research
   Startup Project of Henan Agricultural University [30501247, 30500789];
   Doctoral Research Startup Project of Jinling Institute of Technology
   [jit-b-202218]
FX This work was supported by the Zhejiang Provincial Basic Public Welfare
   Research Program Project (LGF20H280007), the Open Fund of State Key
   Laboratory of Tea Plant Biology and Utilization (SKLTOF20200127 and
   SKLT0F20200108), the Doctoral Research Startup Project of Henan
   Agricultural University (30501247 and 30500789), and the Doctoral
   Research Startup Project of Jinling Institute of Technology
   (jit-b-202218).
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NR 87
TC 3
Z9 3
U1 0
U2 35
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD APR 28
PY 2023
VL 10
AR 1168049
DI 10.3389/fnut.2023.1168049
PG 15
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA G0LO6
UT WOS:000986173500001
PM 37187875
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Chung, CM
   Lin, TH
   Chen, JW
   Leu, HB
   Yin, WH
   Ho, HY
   Sheu, SH
   Tsai, WC
   Chen, JH
   Lin, SJ
   Pan, WH
AF Chung, Chia-Min
   Lin, Tsung-Hsien
   Chen, Jaw-Wen
   Leu, Hsin-Bang
   Yin, Wei-Hsian
   Ho, Hung-Yun
   Sheu, Sheng-Hsiung
   Tsai, Wei-Chuan
   Chen, Jyh-Hong
   Lin, Shing-Jong
   Pan, Wen-Harn
TI Common quantitative trait locus downstream of RETN gene
   identified by genome-wide association study is associated with risk of
   type 2 diabetes mellitus in Han Chinese: a Mendelian randomization
   effect
SO DIABETES-METABOLISM RESEARCH AND REVIEWS
LA English
DT Article
DE GWAS; T2DM; Mendelian randomization
ID PLASMA RESISTIN LEVELS; MYOCARDIAL-INFARCTION; INSULIN-RESISTANCE;
   METABOLIC SYNDROME; CIRCULATING LEVELS; ENDOTHELIAL-CELLS; OXIDATIVE
   STRESS; OBESITY; POLYMORPHISMS; ADIPONECTIN
AB ObjectivePlasma resistin level is a potential molecular link between obesity and diabetes. Causal role of resistin, type 2 diabetes mellitus (T2DM) and genetic variants have not been thoroughly investigated. Therefore, we conducted a genome-wide association study (GWAS) to identify quantitative trait loci associated with resistin levels and investigated whether these variants were prospectively associated with the development of metabolic syndrome (MetS) and T2DM in an independent community-based cohort, the CardioVascular Disease risk FACtors Two-township Study (CVDFACTS).
   Research Design and MethodsWe genotyped 382 young-onset hypertensive (YOH) subjects with Illumina HumanHap550 chips and searched for quantitative trait loci (QTLs) of resistin in the 1(st) stage GWAS and confirmed the finding in another 559 YOH subjects. Logistic regression was used to examine the Mendelian randomization effects between genotypes of confirmed QTLs and metabolic outcomes in 3400 subjects of CVDFACTS.
   ResultsTwo single nucleotide polymorphisms (SNP) (rs3745367 and rs1423096) were significantly associated with resistin levels (p=5.52x10(-15) and p=2.54x10(-20)) and replicated in another 559 YOH subjects (p=1.29x10(-3) and p=1.13x10(-7)), respectively. The SNP rs1423096 was further associated with the levels of HDL-C (p=0.006), the risk of MetS (OR=2.21, p=0.0034) and T2DM (OR=1.62, p=0.0063) in the CVDFACTS. People with the haplotypes A-G and G-G determined by rs3745367 and rs1423096 showed a significantly increased T2DM risk (p=0.0068 and p=0.0035, respectively) compared with those with A-A haplotype.
   ConclusionWe have found that rs3745367 and rs1423096 on the RETN gene were significantly associated with resistin levels. However, rs1423096, downstream of RETN, seems to be associated with MetS and T2DM risk more so than rs3745367. The established genotype-disease association points to a causal association of resistin and T2DM. Copyright (c) 2013 John Wiley & Sons, Ltd.
C1 [Chung, Chia-Min; Pan, Wen-Harn] Acad Sinica, Inst Biomed Sci, Taipei 115, Taiwan.
   [Chung, Chia-Min; Pan, Wen-Harn] Natl Hlth Res Inst, Inst Populat Hlth Sci, Div Hlth Serv Res & Prevent Med, Miaoli, Taiwan.
   [Lin, Tsung-Hsien; Sheu, Sheng-Hsiung] Kaohsiung Med Univ Hosp, Div Cardiol, Dept Internal Med, Kaohsiung, Taiwan.
   [Lin, Tsung-Hsien; Sheu, Sheng-Hsiung] Kaohsiung Med Univ, Dept Internal Med, Coll Med, Fac Med, Kaohsiung, Taiwan.
   [Chen, Jaw-Wen; Leu, Hsin-Bang; Lin, Shing-Jong] Natl Yang Ming Univ, Cardiovasc Res Ctr, Taipei 112, Taiwan.
   [Chen, Jaw-Wen] Taipei Vet Gen Hosp, Dept Med Res & Educ, Taipei, Taiwan.
   [Yin, Wei-Hsian] Natl Yang Ming Univ, Div Cardiol, Cheng Hsin Gen Hosp, Taipei 112, Taiwan.
   [Yin, Wei-Hsian] Natl Yang Ming Univ, Fac Med, Sch Med, Taipei 112, Taiwan.
   [Ho, Hung-Yun] Taichung Vet Gen Hosp, Taichung, Taiwan.
   [Tsai, Wei-Chuan; Chen, Jyh-Hong] Natl Cheng Kung Univ, Coll Med, Tainan 70101, Taiwan.
C3 Academia Sinica - Taiwan; National Health Research Institutes - Taiwan;
   Kaohsiung Medical University; Kaohsiung Medical University Hospital;
   Kaohsiung Medical University; National Yang Ming Chiao Tung University;
   Taipei Veterans General Hospital; National Yang Ming Chiao Tung
   University; Cheng Hsin General Hospital; National Yang Ming Chiao Tung
   University; Taichung Veterans General Hospital; National Cheng Kung
   University
RP Pan, WH (corresponding author), Acad Sinica, Inst Biomed Sci, 128 Acad Rd Sec 2, Taipei 115, Taiwan.
EM pan@ibms.sinica.edu.tw
RI Sheu, Sheng-Hsiung/C-7445-2009; Romeo, Stefano/L-6861-2015; Lin,
   Tsung-Hsien/D-4514-2009; Pan, Wen-Harn/F-9972-2010; Chen,
   jianhui/AAY-1195-2021
OI Lin, Tsung-Hsien/0000-0002-7226-8730
FU Department of Health [DOH90-TD-1037]; National Science Council
   [NSC91-3112-P-001-025-YGPCP91-25]; Academia Sinica [AS91IBMS2PP-A];
   Academia Sinica Genomics and Proteomics Program, Taiwan
FX This research has been supported by the Department of Health
   (DOH90-TD-1037), the National Science Council
   (NSC91-3112-P-001-025-YGPCP91-25), Academia Sinica (AS91IBMS2PP-A) and
   Academia Sinica Genomics and Proteomics Program (2003-2006) in Taiwan.
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NR 42
TC 34
Z9 36
U1 0
U2 8
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1520-7552
EI 1520-7560
J9 DIABETES-METAB RES
JI Diabetes-Metab. Res. Rev.
PD MAR
PY 2014
VL 30
IS 3
BP 232
EP 240
DI 10.1002/dmrr.2481
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA AD1VU
UT WOS:000333022600007
PM 24123702
DA 2025-06-11
ER

PT J
AU Guyton, JR
   Slee, AE
   Anderson, T
   Fleg, JL
   Goldberg, RB
   Kashyap, ML
   Marcovina, SM
   Nash, SD
   O'Brien, KD
   Weintraub, WS
   Xu, P
   Zhao, XQ
   Boden, WE
AF Guyton, John R.
   Slee, April E.
   Anderson, Todd
   Fleg, Jerome L.
   Goldberg, Ronald B.
   Kashyap, Moti L.
   Marcovina, Santica M.
   Nash, Stephen D.
   O'Brien, Kevin D.
   Weintraub, William S.
   Xu, Ping
   Zhao, Xue-Qiao
   Boden, William E.
TI Relationship of Lipoproteins to Cardiovascular Events The AIM-HIGH Trial
   (Atherothrombosis Intervention in Metabolic Syndrome With Low HDL/High
   Triglycerides and Impact on Global Health Outcomes)
SO JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
LA English
DT Article
DE cardiovascular events; clinical trial; GPR109A; lipoproteins; niacin
ID RELEASE NICOTINIC-ACID; HEART-DISEASE; NIACIN; PREVENTION; STRESS
AB Objectives This study sought to examine the relationship between niacin treatment, lipoproteins, and cardiovascular (CV) outcomes in this secondary analysis of the AIM-HIGH (Atherothrombosis Intervention in Metabolic Syndrome With Low HDL/High Triglycerides and Impact on Global Health Outcomes) trial.
   Background During a 3-year follow-up in 3,414 patients with established CV disease and low high-density lipoprotein cholesterol (HDL-C) levels, combined niacin + low-density lipoprotein cholesterol (LDL-C)-lowering therapy did not reduce CV events compared with LDL-C-lowering therapy alone.
   Methods Subjects taking simvastatin and/or ezetimibe were randomized to receive extended-release (ER) niacin 1,500 to 2,000 mg or minimal immediate-release niacin (<= 150 mg) as placebo at bedtime. LDL-C levels in both groups were maintained from 40 to 80 mg/dl. Hazard ratios were estimated by using Cox proportional hazards models for relationships between lipoproteins and the composite endpoint of CV death, myocardial infarction, acute coronary syndrome, ischemic stroke, or symptom-driven revascularization.
   Results CV outcomes were not associated with ER niacin in any baseline lipoprotein tertile. In a subset of patients in both the highest triglyceride (>= 198 mg/dl) and lowest HDL-C (<33 mg/dl) tertiles, ER niacin showed a trend toward benefit (hazard ratio: 0.74, p = 0.073). In-trial LDL-C levels, non-HDL-C levels, and the total cholesterol/HDL-C ratio were positively associated with CV events in the control group, but these relationships were absent in the ER niacin group.
   Conclusions Baseline lipoprotein tertiles did not predict differential benefit or harm with ER niacin added to LDL-C-lowering therapy, but a small dyslipidemic subgroup may benefit. ER niacin attenuated expected relationships of lipoprotein risk factors with CV events, raising the possibility that nonlipoprotein actions of niacin could affect risk. (Niacin Plus Statin to Prevent Vascular Events [AIM-HIGH]; NCT00120289) (C) 2013 by the American College of Cardiology Foundation
C1 [Guyton, John R.] Duke Univ, Med Ctr, Dept Med, Durham, NC 27710 USA.
   [Slee, April E.; Xu, Ping] Axio Res, Seattle, WA USA.
   [Anderson, Todd] Univ Calgary, Libin Cardiovasc Inst, Calgary, AB, Canada.
   [Fleg, Jerome L.] NHLBI, Bethesda, MD 20892 USA.
   [Goldberg, Ronald B.] Univ Miami, Leonard M Miller Sch Med, Dept Med, Hollywood, FL USA.
   [Kashyap, Moti L.] Vet Affairs Med Ctr, Long Beach, CA USA.
   [Kashyap, Moti L.] Univ Calif Irvine, Dept Med, Irvine, CA 92717 USA.
   [Marcovina, Santica M.; O'Brien, Kevin D.; Zhao, Xue-Qiao] Univ Washington, Dept Med, Seattle, WA USA.
   [Nash, Stephen D.] SUNY Hlth Sci Ctr, Dept Med, Syracuse, NY 13210 USA.
   [Weintraub, William S.] Ctr Heart & Vasc Hlth, Newark, DE USA.
   [Boden, William E.] Samuel S Stratton VA Med Ctr, Dept Med, Albany, NY USA.
C3 Duke University; Axio Research, LLC; Libin Cardiovascular Institute Of
   Alberta; University of Calgary; National Institutes of Health (NIH) -
   USA; NIH National Heart Lung & Blood Institute (NHLBI); US Department of
   Veterans Affairs; Veterans Health Administration (VHA); VA Long Beach
   Healthcare System; University of California System; University of
   California Irvine; University of Washington; University of Washington
   Seattle; State University of New York (SUNY) System; State University of
   New York (SUNY) Upstate Medical Center
RP Guyton, JR (corresponding author), Duke Univ, Med Ctr, Box 3510,200 Trent Dr, Durham, NC 27710 USA.
EM john.guyton@duke.edu
RI Boden, William/HPB-8916-2023; O'Brien, Kevin/HDO-1461-2022
OI Guyton, John/0000-0003-0224-7923; O'Brien, Kevin/0000-0002-2293-9196;
   Kashyap, Moti/0000-0002-0052-8302
FU National Heart, Lung, and Blood Institute [U01-HL-081616,
   U01-HL-081649]; Abbott Laboratories; Merck Co.; Kowa Pharmaceuticals
   America; Regeneron Pharmaceuticals; Sanofi US; Genzyme Corporation; Isis
   Pharmaceuticals; Amgen; Amarin Corporation; GlaxoSmithKline USA; Roche;
   Daiichi Sankyo; GlaxoSmithKline; AstraZeneca; Eli Lilly and Company;
   Sanofi; Amarin Pharmaceuticals; Pfizer
FX This work was supported by the National Heart, Lung, and Blood Institute
   (U01-HL-081616 and U01-HL-081649) and by an unrestricted grant from
   Abbott Laboratories. Abbott Laboratories donated the extended-release
   niacin, the matching placebo, and the ezetimibe; Merck & Co. donated the
   simvastatin. Neither of these companies had any role in the oversight or
   design of the study, or in the analysis or interpretation of the data.
   Dr. Guyton has received consultation fees from Merck & Co. and Kowa
   Pharmaceuticals America; research grants from Merck & Co., Regeneron
   Pharmaceuticals, Sanofi US, Genzyme Corporation, Isis Pharmaceuticals,
   Amgen, Amarin Corporation, and GlaxoSmithKline USA; and owns $14,000
   common stock in Eli Lilly and Company. Dr. Anderson has received
   clinical trials research funding from Merck & Co., Roche, and Abbott
   Laboratories. Dr. Goldberg has received research funding from Abbott
   Laboratories, Daiichi Sankyo, GlaxoSmithKline, and Roche. Dr. Kashyap
   has received research grants from Abbott Laboratories, Amgen,
   AstraZeneca, Eli Lilly and Company, Roche, and Sanofi; and honoraria as
   a speaker/consultant for Abbott Laboratories, Amarin Pharmaceuticals,
   Kos (was bought by Abbott Laboratories in 2006), and Merck & Co. Dr.
   Nash is a member of the speaker's bureau for Daiichi Sankyo, Takeda
   Pharmaceutical, and Amarin Pharmaceuticals; and has received research
   funding from Amarin Pharmaceuticals, AstraZeneca, Merck & Co., and
   Roche. Dr. Zhao has received research funding from Pfizer, Merck & Co.,
   Abbott Laboratories, and Daiichi Sankyo. All other authors have reported
   that they have no relationships relevant to the contents of this paper
   to disclose.
CR Albers JJ, 2013, J AM COLL CARDIOL, V62, P1575, DOI 10.1016/j.jacc.2013.06.051
   [Anonymous], 1975, JAMA-J AM MED ASSOC, V231, P360
   [Anonymous], AM COLL CARD ANN SCI
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NR 22
TC 140
Z9 146
U1 0
U2 15
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0735-1097
EI 1558-3597
J9 J AM COLL CARDIOL
JI J. Am. Coll. Cardiol.
PD OCT 22
PY 2013
VL 62
IS 17
BP 1580
EP 1584
DI 10.1016/j.jacc.2013.07.023
PG 5
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 238HY
UT WOS:000325937400007
PM 23916935
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Machi, JF
   Bernardes, N
   Mostarda, C
   Moraes-Silva, IC
   Irigoyen, MC
   De Angelis, K
   Wichi, RB
AF Machi, Jacqueline F.
   Bernardes, Nathalia
   Mostarda, Cristiano
   Moraes-Silva, Ivana Cinthya
   Irigoyen, Maria Claudia
   De Angelis, Katia
   Wichi, Rogerio B.
TI Walking promotes metabolic and baroreflex sensitivity improvement in
   fructose-fed male rats
SO EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
LA English
DT Article
DE Metabolic syndrome; Physical exercise; Walking; Cardiovascular system
ID LOW-INTENSITY EXERCISE; INSULIN-RESISTANCE; OXIDATIVE STRESS; GLUCOSE;
   HYPERTENSION; RESPONSES; WEIGHT; SYSTEM; DYSFUNCTION; REDUCTION
AB The aim of this study was to investigate metabolic and cardiovascular responses to walking in fructose-fed rats. Male Wistar rats were divided into control (C), sedentary fructose (SF) and walking fructose (WF). Fructose-fed rats received d-fructose (100 g/l). WF rats walked on a treadmill at constant load (0.3 km/h) during 1 h/day, 5 days/week for 8 weeks. Measurements of triglyceride concentrations, adipose tissue and glycemia were carried out together with insulin tolerance test to evaluate metabolic profile. Arterial pressure (AP) signals were directly recorded. Baroreflex sensitivity (BR) was evaluated by the reflex tachycardia (TR) and bradycardia (BR) to AP changes. The results showed that walking decreased the adipose tissue (SF: 6.5 +/- A 0.4; WF: 2.8 +/- A 0.1; C: 3.0 +/- A 0.3 g), blood triglyceride levels (SF: 291 +/- A 6.5; WF: 150 +/- A 8.1; C: 103 +/- A 4.5 mg/dl) and increased insulin sensitivity (SF: 2.5 +/- A 0.2; WF: 3.3 +/- A 0.32; C: 4.8 +/- A 0.4 %/min). Baroreflex sensitivity was improved in the WF group expressed by BR (SF: 0.75 +/- A 0.10; WF: 1.18 +/- A 0.10; C: 1.5 +/- A 0.14 ms/mmHg) and TR (SF: 0.80 +/- A 0.12; WF: 1.21 +/- A 0.10; C: 1.35 +/- A 0.11 ms/mmHg), as well as when verified by the alpha index. Although the WF group showed decreased AP when compared with the SF group, the values still enhanced in relation to C rats (SF: 137 +/- A 2; WF: 129 +/- A 1; C: 115 +/- A 6 mmHg). Our findings allow a better understanding of the effects of walking, a low-intensity exercise training, on the hemodynamic and metabolic aspects of male rats with metabolic syndrome and indicate that walking seems to be particularly effective in treating metabolic disturbances in this model.
C1 [Machi, Jacqueline F.; Mostarda, Cristiano; Moraes-Silva, Ivana Cinthya; Irigoyen, Maria Claudia] Univ Sao Paulo, Sch Med, Heart Inst InCor, Hypertens Unit, BR-05403900 Sao Paulo, Brazil.
   [Bernardes, Nathalia; De Angelis, Katia] Nove Julho Univ, Translat Physiol Lab, Sao Paulo, Brazil.
   [Wichi, Rogerio B.] Univ Fed Sergipe, Dept Phys Educ, Sergipe, Brazil.
C3 Universidade de Sao Paulo; Universidade Nove de Julho; Universidade
   Federal de Sergipe
RP Irigoyen, MC (corresponding author), Univ Sao Paulo, Sch Med, Heart Inst InCor, Hypertens Unit, Av Dr Eneas de Carvalho Aguiar 44, BR-05403900 Sao Paulo, Brazil.
EM hipirigoyen@incor.usp.br
RI Bernardes, Nathalia/L-7460-2015; Moraes-Silva, Ivana/K-2557-2019;
   Mostarda, Cristiano/AAG-4087-2019; DE ANGELIS, KATIA/I-6098-2016;
   Irigoyen, maria Claudia/N-6880-2014
OI DE ANGELIS, KATIA/0000-0002-3640-9049; Irigoyen, maria
   Claudia/0000-0003-2097-3662; Mostarda, Cristiano
   Teixeira/0000-0002-1305-1697
FU Fundacao de Amparo a Pesquisa do Estado de Sao Paulo [FAPESP 08/51525-8,
   07/57595-5]; Conselho Nacional de Pesquisa [CNPq 482520/2009-4,
   306011/2010-7]; CNPq-BPQ fellowships
FX This study was supported by Fundacao de Amparo a Pesquisa do Estado de
   Sao Paulo (FAPESP 08/51525-8, 07/57595-5) and Conselho Nacional de
   Pesquisa (CNPq 482520/2009-4, 306011/2010-7). MCI and kDa are recipients
   of CNPq-BPQ fellowships.
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NR 54
TC 18
Z9 20
U1 0
U2 3
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1439-6319
EI 1439-6327
J9 EUR J APPL PHYSIOL
JI Eur. J. Appl. Physiol.
PD JAN
PY 2013
VL 113
IS 1
BP 41
EP 49
DI 10.1007/s00421-012-2411-z
PG 9
WC Physiology; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology; Sport Sciences
GA 063WV
UT WOS:000313033600005
PM 22565302
DA 2025-06-11
ER

PT J
AU Bo, S
   Ciccone, G
   Baldi, I
   Gambino, R
   Mandrile, C
   Durazzo, M
   Gentile, L
   Cassader, M
   Cavallo-Perin, P
   Pagano, G
AF Bo, S.
   Ciccone, G.
   Baldi, I.
   Gambino, R.
   Mandrile, C.
   Durazzo, M.
   Gentile, L.
   Cassader, M.
   Cavallo-Perin, P.
   Pagano, G.
TI Plasma visfatin concentrations after a lifestyle intervention were
   directly associated with inflammatory markers
SO NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
LA English
DT Article
DE C-reactive protein; Metabolic syndrome; Visfatin; Waist circumference
ID COLONY-ENHANCING FACTOR; MESSENGER-RNA EXPRESSION; TYPE-2
   DIABETES-MELLITUS; METABOLIC SYNDROME; ADIPOSE-TISSUE; WEIGHT-LOSS;
   INSULIN-RESISTANCE; SERUM VISFATIN; VISCERAL FAT; OBESITY
AB Background and aims: The biological activity and regulation of the novel adipokine visfatin are stilt largely unknown. Our aim was to evaluate if visfatin plasma concentrations may be influenced by a lifestyle intervention.
   Methods and results: Out of 335 dysmetabolic patients from a population-based cohort, randomized to receive a lifestyle intervention program (intervention group) or family physician usual care (controls), 20 patients per group were randomly selected for plasma visfatin determination. The before-after variation (Delta) in visfatin concentration at 1-year from randomization, and the correlations between Delta visfatin and intervention-induced changes in waist circumference, fasting glucose, markers of inflammation, and oxidative stress were evaluated.
   The intervention group showed a significant improvement in waist circumference, and many metabolic/inflammatory variabtes, while the controls worsened. Visfatin concentrations slightly decreased in the former and significantly increased in the controls (Delta visfatin = -2.4 vs 66.0 ng/ml, p < 0.001). In robust regression models, the following variables resulted associated with Delta visfatin: Delta waist circumference, Delta fasting glucose, Delta hs-CRP (high-sensitivity C-reactive protein) and Delta TNF alpha (tumor necrosis factor-alpha). Significant effects on Delta visfatin of Delta TNF alpha (beta = 16.8; 6.1-25.6; p = 0.003) and, modified by group, of Delta hs-CRP (beta = 29.8; 95% CI 15.4-44.2; p < 0.001 and beta = 4.2; 2.9-5.5; p < 0.001 in the control and intervention group, respectivety) were detected. By controlling for Delta waist, the effects of Delta TNF alpha and of Delta hs-CRP on Delta visfatin by group did not change, while Delta waist was no longer associated. The association between Delta visfatin and Delta glucose was no longer significant, after adjusting for Delta hs-CRP.
   Conclusion: Visfatin values increased with waist circumference and were associated with variations of inflammatory markers, suggesting participation in inflammatory mechanisms. (c) 2008 Elsevier B.V. All rights reserved.
C1 [Bo, S.; Gambino, R.; Mandrile, C.; Durazzo, M.; Cassader, M.; Cavallo-Perin, P.; Pagano, G.] Univ Turin, Dept Internal Med, I-10126 Turin, Italy.
   [Ciccone, G.; Baldi, I.] S Giovanni Battista Hosp, Epidemiol Unit, Turin, Italy.
   [Gentile, L.] Hosp Asti, Diabet Clin, Asti, Italy.
C3 University of Turin; A.O.U. Citta della Salute e della Scienza di
   Torino; AOU San Giovanni Battista-Molinette
RP Bo, S (corresponding author), Univ Turin, Dept Internal Med, Corso Dogliotti 14, I-10126 Turin, Italy.
EM sbo@molinette.piemonte.it
RI Baldi, Ileana/J-2788-2019; Bo, Simona/AAC-1110-2019; GAMBINO,
   Roberto/AAC-7517-2022; Ciccone, Giovannino/K-3136-2016
OI Ciccone, Giovannino/0000-0001-7644-9574; DURAZZO,
   Marilena/0000-0003-2450-5911; Bo, Simona/0000-0001-6862-8628; BALDI,
   ILEANA/0000-0002-8578-9164
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NR 41
TC 16
Z9 20
U1 0
U2 1
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0939-4753
EI 1590-3729
J9 NUTR METAB CARDIOVAS
JI Nutr. Metab. Carbiovasc. Dis.
PD JUL
PY 2009
VL 19
IS 6
BP 423
EP 430
DI 10.1016/j.numecd.2008.09.001
PG 8
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism; Nutrition
   & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism;
   Nutrition & Dietetics
GA 478VY
UT WOS:000268617900007
PM 19073361
DA 2025-06-11
ER

PT J
AU Kivimäki, M
   Head, J
   Ferrie, JE
   Singh-Manoux, A
   Westerlund, H
   Vahtera, J
   Leclerc, A
   Melchior, M
   Chevalier, A
   Alexanderson, K
   Zins, M
   Goldberg, M
AF Kivimaki, M.
   Head, J.
   Ferrie, J. E.
   Singh-Manoux, A.
   Westerlund, H.
   Vahtera, J.
   Leclerc, A.
   Melchior, M.
   Chevalier, A.
   Alexanderson, K.
   Zins, M.
   Goldberg, M.
TI Sickness absence as a prognostic marker for common chronic conditions:
   analysis of mortality in the GAZEL study
SO OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
LA English
DT Article
ID FUTURE DISABILITY PENSION; CORONARY-HEART-DISEASE; WHITEHALL-II;
   METABOLIC SYNDROME; SUBSTANCE USE; RISK MARKER; SELF-REPORT; HEALTH;
   COHORT; DEPRESSION
AB Objectives: To determine whether sickness absence is a prognostic marker in terms of mortality among people with common chronic conditions.
   Methods: Prospective occupational cohort study of 13 077 men and 4871 women aged 37-51 from the National Gas and Electricity Company, France. Records of physician-certified sickness absences over a 3-year period were obtained from employers' registers. Chronic conditions were assessed in annual surveys over the same period. The main outcome measure was all-cause mortality (803 deaths, mean follow-up after assessment of sickness absence: 13.9 years).
   Results: In Cox proportional hazard models adjusted for age, sex, socioeconomic position and co-morbidity, >28 annual sickness-absence days versus no absence days was associated with an excess mortality risk among those with cancer (hazard ratio 5.4, 95% CI 2.2 to 13.1), depression (1.7, 1.1 to 2.8), chronic bronchitis or asthma (2.7, 1.6 to 4.6) and hypertension (1.6, 1.0 to 2.6). The corresponding hazard ratios for more than five long (>14 days) sickness-absence episodes per 10 person-years versus no such episodes were 5.4 (2.2 to 13.1), 1.8 (1.3 to 2.7), 2.0 (1.3 to 3.2) and 1.8 (1.2 to 2.7), respectively. Areas under receiver operating characteristics curves for these absence measures varied between 0.56 and 0.73, indicating the potential of these measures to distinguish groups at high risk of mortality. The findings were consistent across sex, age and socioeconomic groups and in those with and without co-morbid conditions.
   Conclusion: Data on sickness absence may provide useful prognostic information for common chronic conditions at the population level.
C1 [Kivimaki, M.; Head, J.; Ferrie, J. E.] UCL, Dept Epidemiol & Publ Hlth, London WC1E 6BT, England.
   [Singh-Manoux, A.; Leclerc, A.; Melchior, M.; Zins, M.; Goldberg, M.] Hop Paul Brousse, INSERM, U687, IFR69, Villejuif, France.
   [Westerlund, H.] Stockholm Univ, Stress Res Inst, S-10691 Stockholm, Sweden.
   [Vahtera, J.] Finnish Inst Occupat Hlth, Helsinki, Finland.
   [Chevalier, A.] French Inst Publ Hlth Surveillance, Dept Occupat Hlth, St Maurice, France.
   [Alexanderson, K.] Karolinska Inst, Sect Personal Injury Prevent, Dept Clin Neurosci, Stockholm, Sweden.
C3 University of London; University College London; Institut National de la
   Sante et de la Recherche Medicale (Inserm); Assistance Publique Hopitaux
   Paris (APHP); Hopital Universitaire Paul-Brousse - APHP; Stockholm
   University; Finnish Institute of Occupational Health; Sante publique
   France; Karolinska Institutet
RP Kivimäki, M (corresponding author), UCL, Dept Epidemiol & Publ Hlth, 1-19 Torrington Pl, London WC1E 6BT, England.
EM m.kivimaki@ucl.ac.uk
RI Westerlund, Hugo/IZP-7925-2023; Ferrie, Jane/AAZ-2009-2020; Vahtera,
   Jussi/J-3271-2013; Kivimaki, Mika/B-3607-2012; Alexanderson,
   Kristina/J-3429-2013; Head, Jenny/GYA-2625-2022; Melchior,
   Maria/E-3992-2017; Singh-Manoux, Archana/F-6804-2013; Goldberg,
   Marcel/I-7834-2012
OI Kivimaki, Mika/0000-0002-4699-5627; Head, Jennifer/0000-0002-6054-0872;
   Singh-Manoux, Archana/0000-0002-1244-5037; Alexanderson,
   Kristina/0000-0002-9313-3413; Goldberg, Marcel/0000-0002-6161-5880
FU Academy of Finland [117604, 124322, 124271]; Finnish Environment Fund;
   Swedish Council for Working Life and Social Research; MRC [8802774];
   European Science Foundation; EDF-GDF; INSERM; Association de la
   Recherche sur le Cancer; Fondation de France
FX MK and JV are supported by the Academy of Finland (projects 117604,
   124322 and 124271) and the Finnish Environment Fund, and HW and KA by
   the Swedish Council for Working Life and Social Research. JEF is
   supported by the MRC (grant number 8802774) and AS-M by a EUYRI award
   from the European Science Foundation. The GAZEL cohort was funded by
   EDF-GDF and INSERM, and received grants from the Association de la
   Recherche sur le Cancer and from the Fondation de France.
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NR 34
TC 32
Z9 36
U1 0
U2 2
PU B M J PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 1351-0711
J9 OCCUP ENVIRON MED
JI Occup. Environ. Med.
PD DEC
PY 2008
VL 65
IS 12
BP 820
EP 826
DI 10.1136/oem.2007.038398
PG 7
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA 373US
UT WOS:000260999600006
PM 18611969
OA Green Accepted, Green Submitted
DA 2025-06-11
ER

PT J
AU Darroudi, S
   Fereydouni, N
   Tayefi, M
   Esmaily, H
   Sadabadi, F
   Khashyarmanesh, Z
   Tayefi, B
   Haghighi, HM
   Timar, A
   Mohammadpour, AH
   Gonoodi, K
   Ferns, GA
   Hoseini, SJ
   Ghayour-Mobarhan, M
AF Darroudi, Susan
   Fereydouni, Narges
   Tayefi, Maryam
   Esmaily, Habibollah
   Sadabadi, Fatemeh
   Khashyarmanesh, Zahra
   Tayefi, Batool
   Haghighi, Hamideh Moalemzadeh
   Timar, Ameneh
   Mohammadpour, Amir Hooshang
   Gonoodi, Kayhan
   Ferns, Gordon A.
   Hoseini, Seyed Javad
   Ghayour-Mobarhan, Majid
TI Altered serum Zinc and Copper in Iranian Adults who were of normal
   weight but metabolically obese
SO SCIENTIFIC REPORTS
LA English
DT Article
ID METAL-RESPONSIVE TRANSCRIPTION; CORONARY-HEART-DISEASE; OXIDATIVE
   STRESS; INSULIN-RESISTANCE; NATIONAL-HEALTH; RISK; HOMEOSTASIS;
   SUPEROXIDE; PREVALENCE; INDEX
AB Metabolically obese normal weight (MONW) individuals are potentially at increased risk of developing metabolic syndrome. Serum zinc and copper concentrations were assessed in individuals with MONW to determine whether MONW is associated with altered serum zinc and/or copper status. Normal weight subjects (total n = 2419; 1298 men and 1121 women), were recruited as part of Mashhad Stroke and Heart Association Disorder (MASHAD) Study cohort. They were divided into two groups according to the presence or absence of MetS, defined using IDF criteria. Serum zinc and copper concentrations were determined by atomic absorption. Of the 2419 normal weight adults, 377 had MetS. Of this group, 53.7% and 49.7% had a serum zinc <70 mu g/dl(Q1) (p = 0.001) or a serum copper <79 mu g/dl(Q1) respectively. Furthermore, 27.3% had a serum copper >131 mu g/dl(Q4) (p = 0.034), and 18.8% had a serum zinc >95 mu g/dl(Q4). Logistic regression analysis was performed to determine the odds ratio (OR) for an association of serum zinc, copper and zinc to copper ratio with MetS in normal weight subjects. The subjects with a serum zinc >95 mu g/dl(Q4) had 0.386 [OR: 0.614(95%CI 0.457-0.823)] lower chance of MetS (p = 0.001) and the subjects with a serum copper >131(Q4) had OR 1.423 (95% CI: 1.09-1.857) higher chance of MetS (p = 0.009). These data remained significant after adjustment for age and sex, for serum zinc and copper, respectively. Furthermore, our results strongly suggested that zinc and copper were the independent risk factor for metabolic syndrome in normal weight subjects. There is an imbalance between serum copper and zinc concentrations among individuals with MONW when compared with normal BMI individuals without MetS. This may increase the risk of individuals with MONW developing conditions associated with this imbalance, such as diabetes and cardiovascular disease.
C1 [Darroudi, Susan; Fereydouni, Narges; Sadabadi, Fatemeh] Mashhad Univ Med Sci, Fac Med, Student Res Comm, Mashhad, Razavi Khorasan, Iran.
   [Tayefi, Maryam] Univ Hosp North Norway, Norwegian Ctr E Hlth Res, Tromso, Norway.
   [Esmaily, Habibollah] Mashhad Univ Med Sci, Sch Hlth, Dept Biostat, Mashhad, Razavi Khorasan, Iran.
   [Khashyarmanesh, Zahra; Haghighi, Hamideh Moalemzadeh] Mashhad Univ Med Sci, Sch Pharmacol, Dept Med Chem, Mashhad, Razavi Khorasan, Iran.
   [Tayefi, Batool] Iran Univ Med Sci, Prevent Med & Publ Hlth Res Ctr, Tehran, Iran.
   [Timar, Ameneh] Hakim Sabzevary Univ Sabzevar, Fac Basic Sci, Sabzevar, Iran.
   [Mohammadpour, Amir Hooshang] Mashhad Univ Med Sci, Pharmaceut Res Ctr, Pharmaceut Inst Technol, Mashhad, Razavi Khorasan, Iran.
   [Mohammadpour, Amir Hooshang] Mashhad Univ Med Sci, Sch Pharm, Dept Clin Pharm, Mashhad, Razavi Khorasan, Iran.
   [Gonoodi, Kayhan] Mashhad Univ Med Sci, Fac Med, Dept Nutr, Mashhad, Razavi Khorasan, Iran.
   [Ferns, Gordon A.] Brighton & Sussex Med Sch, Dept Med Educ, Brighton BN1 9PH, E Sussex, England.
   [Hoseini, Seyed Javad] Mashhad Univ Med Sci, Sch Med, Dept Biotechnol, Mashhad, Razavi Khorasan, Iran.
   [Ghayour-Mobarhan, Majid] Mashhad Univ Med Sci, Metab Syndrome Res Ctr, Sch Med, Mashhad, Razavi Khorasan, Iran.
C3 Mashhad University of Medical Sciences; UiT The Arctic University of
   Tromso; University Hospital of North Norway; Mashhad University of
   Medical Sciences; Mashhad University of Medical Sciences; Iran
   University of Medical Sciences; Mashhad University of Medical Sciences;
   Mashhad University of Medical Sciences; Mashhad University of Medical
   Sciences; University of Sussex; University of Brighton; Mashhad
   University of Medical Sciences; Mashhad University of Medical Sciences
RP Mohammadpour, AH (corresponding author), Mashhad Univ Med Sci, Pharmaceut Res Ctr, Pharmaceut Inst Technol, Mashhad, Razavi Khorasan, Iran.; Mohammadpour, AH (corresponding author), Mashhad Univ Med Sci, Sch Pharm, Dept Clin Pharm, Mashhad, Razavi Khorasan, Iran.; Ghayour-Mobarhan, M (corresponding author), Mashhad Univ Med Sci, Metab Syndrome Res Ctr, Sch Med, Mashhad, Razavi Khorasan, Iran.
EM mohamadpoorah@mums.ac.ir; ghayourm@mums.ac.ir
RI Fereydouni, Narges/ABD-8931-2020; Tayefi Nasrabadi, Batool/U-7014-2019;
   Ghayour-Mobarhan, Majid/AAY-5963-2020
OI Hoseini, Seyed Javad/0000-0002-9836-7745; tayefi,
   maryam/0000-0003-4637-7754; Tayefi Nasrabadi, Batool/0000-0002-0913-7324
FU Mashhad University of Medical Science
FX This study was support by grant from Mashhad University of Medical
   Science.
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NR 54
TC 7
Z9 7
U1 0
U2 6
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD OCT 16
PY 2019
VL 9
AR 14874
DI 10.1038/s41598-019-51365-9
PG 8
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA JE0ZF
UT WOS:000490422000044
PM 31619721
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Reddy, PY
   Giridharan, NV
   Reddy, GB
AF Reddy, Paduru Yadagiri
   Giridharan, Nappan Veettil
   Reddy, Geereddy Bhanuprakash
TI Activation of sorbitol pathway in metabolic syndrome and increased
   susceptibility to cataract in Wistar-Obese rats
SO MOLECULAR VISION
LA English
DT Article
ID BODY-MASS INDEX; INDUCED DIABETIC CATARACT; AGE-RELATED NUCLEAR; ALDOSE
   REDUCTASE; OXIDATIVE STRESS; DEVELOPING-WORLD; LENS OPACITIES;
   RISK-FACTORS; EYE; CRYSTALLINS
AB Purpose: Obesity is a major public health problem worldwide, and of late, epidemiological studies indicate a preponderance of cataracts under obesity conditions. Although cataract is a multifactorial disorder and various biochemical mechanisms have been proposed, the influence of obesity on cataractogenesis has yet to be investigated. In such a scenario, a suitable animal model that develops cataract following the onset of obesity will be a welcome tool for biomedical research. Therefore, we investigated the molecular and biochemical basis for predisposition to cataract in the obese mutant rat models established in our institute because 15%-20% of these rats develop cataracts spontaneously as they reach 12-15 months of age.
   Methods: We analyzed the major biochemical pathways in the normal lenses of different age groups of our obese mutant rat strains, Wistar/Obese (WNIN/Ob) and WNIN/GR-Ob, the former with euglycemia and the latter with an additional impaired glucose tolerance trait. In addition, sorbitol levels were estimated in the cataractous lenses of the obese rats.
   Results: Except for the polyol pathway, all the principal pathways of the lens remained unaltered. Therefore, sorbitol levels were found to be high in the normal eye lenses of obese rats (WNIN/Ob and WNIN/GR-Ob) compared to their lean controls from three months of age onwards. Between WNIN/Ob and WNIN/GR-Ob, the levels of sorbitol were higher in the latter, suggesting a synergistic effect of impaired glucose tolerance along with obesity in the activation of the sorbitol pathway. Either way, an elevated sorbitol pathway seemed to be the predisposing factor responsible for cataract formation in these mutant rats.
   Conclusions: Activation of the sorbitol pathway indeed enhances the risk of cataract development in conditions such as metabolic syndrome. These rat models thus may be valuable tools for investigating obesity-associated cataract and for developing intervention strategies, based on these findings.
C1 [Reddy, Paduru Yadagiri; Reddy, Geereddy Bhanuprakash] Natl Inst Nutr, Div Biochem, Hyderabad 500604, Andhra Pradesh, India.
   [Giridharan, Nappan Veettil] Natl Inst Nutr, Natl Ctr Lab Anim Sci, Hyderabad 500604, Andhra Pradesh, India.
C3 Indian Council of Medical Research (ICMR); ICMR - National Institute of
   Nutrition (NIN); Indian Council of Medical Research (ICMR); ICMR -
   National Institute of Nutrition (NIN); ICMR - National Animal Resource
   Facility for Biomedical Research (NARFBR)
RP Reddy, GB (corresponding author), Natl Inst Nutr, Div Biochem, Hyderabad 500604, Andhra Pradesh, India.
EM geereddy@yahoo.com
RI Reddy, G. Bhanuprakash/AAJ-3494-2020
OI Reddy, G. Bhanuprakash/0000-0003-4787-3944
FU Indian Council of Medical Research; Department of Biotechnology,
   Government of India
FX The authors acknowledge Ms. M. Satyavani, Mr. N. Yadagiri, and Mr. E.
   Ganesh from National Center for Laboratory Animal Sciences for their
   help in breeding and maintenance of rats. The authors thank Dr. N.
   Balakrishna, National Institute of Nutrition for his help in statistical
   analysis. This work was supported by grants from Indian Council of
   Medical Research and Department of Biotechnology, Government of India.
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NR 50
TC 34
Z9 36
U1 0
U2 1
PU MOLECULAR VISION
PI ATLANTA
PA C/O JEFF BOATRIGHT, LAB B, 5500 EMORY EYE CENTER, 1327 CLIFTON RD, N E,
   ATLANTA, GA 30322 USA
SN 1090-0535
J9 MOL VIS
JI Mol. Vis.
PD FEB 24
PY 2012
VL 18
IS 54-55
BP 495
EP 503
PG 9
WC Biochemistry & Molecular Biology; Ophthalmology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Ophthalmology
GA 905JA
UT WOS:000301267100001
PM 22393276
DA 2025-06-11
ER

PT J
AU Czernichow, S
   Vergnaud, AC
   Galan, P
   Arnaud, J
   Favier, A
   Faure, H
   Huxley, R
   Hercberg, S
   Ahluwalia, N
AF Czernichow, Sebastien
   Vergnaud, Anne-Claire
   Galan, Pilar
   Arnaud, Josiane
   Favier, Alain
   Faure, Henri
   Huxley, Rachel
   Hercberg, Serge
   Ahluwalia, Namanjeet
TI Effects of long-term antioxidant supplementation and association of
   serum antioxidant concentrations with risk of metabolic syndrome in
   adults
SO AMERICAN JOURNAL OF CLINICAL NUTRITION
LA English
DT Article
ID ELEVATED OXIDATIVE STRESS; TYPE-2 DIABETES-MELLITUS; 3RD
   NATIONAL-HEALTH; VITAMIN-E; CARDIOVASCULAR-DISEASE; VEGETABLE
   CONSUMPTION; PRIMARY PREVENTION; CONTROLLED-TRIAL; SELENIUM LEVELS;
   BETA-CAROTENE
AB Background: Limited observational evidence suggests lower antioxidant concentrations in individuals with the metabolic syndrome (MetS); few randomized controlled trials have addressed the effect of multiple antioxidants on the risk of MetS.
   Objective: The objective was to examine the effect of antioxidant supplementation for 7.5 y on the incidence of MetS and the epidemiologic association between baseline serum antioxidant concentrations and the prospective risk of MetS.
   Design: Adults (n = 5220) participating in the SUpplementation en VItamines et Mineraux AntioXydants (SU.VI.MAX) primary prevention trial were randomly assigned to receive a supplement containing a combination of antioxidants (vitamins C and E, beta-carotene, zinc, and selenium) at nutritional doses or a placebo. Subjects were free of MetS at baseline and were followed for 7.5 y.
   Results: Antioxidant supplementation for 7.5 y did not affect the risk of MetS. Baseline serum antioxidant concentrations of beta-carotene and vitamin C, however, were negatively associated with the risk of MetS; the adjusted odds ratios (and 95% CIs) for the highest compared with the lowest tertile were 0.34 (0.21, 0.53; P for trend = 0.0002) and 0.53 (0.35, 0.80; P for trend = 0.01), respectively. Baseline serum zinc concentrations were positively associated with the risk of developing MetS; the adjusted odds ratio (and 95% CI) for the highest compared with the lowest tertile was 1.81 (1.20, 2.72; P for trend = 0.01).
   Conclusions: The experimental finding of no beneficial effects of antioxidant supplementation in a generally well-nourished population is consistent with recent reports of a lack of efficacy of antioxidant supplements. However, the relations observed between the risk of MetS and baseline serum antioxidant concentrations, which probably reflect associations with overall dietary patterns, do support the current recommendations to consume antioxidant-rich foods. This trial was registered at clinicaltrials. gov as NCT00272428. Am J Clin Nutr 2009;90:329-35.
C1 [Czernichow, Sebastien] Univ Paris 13, CNAM, INRA, Nutr Epidemiol Res Unit,UMR U557,INSERM,U1125,CRN, F-93017 Bobigny, France.
   [Czernichow, Sebastien; Hercberg, Serge] Avicenne Hosp, Dept Publ Hlth, Bobigny, France.
   [Arnaud, Josiane; Favier, Alain; Faure, Henri] CHU Grenoble, Biol Integree Dept, F-38043 Grenoble, France.
   [Arnaud, Josiane; Favier, Alain] INSERM, U884, Bioenerget Fondamentale & Appl Lab, Grenoble, France.
   [Arnaud, Josiane; Favier, Alain] Univ Grenoble, UFR Biol Med Pharm & APS, Grenoble, France.
   [Huxley, Rachel] Univ Sydney, George Inst Int Hlth, Sydney, NSW 2006, Australia.
   [Ahluwalia, Namanjeet] Univ Toulouse 3, Fac Med, INSERM, U558, Toulouse, France.
C3 INRAE; heSam Universite; Conservatoire National Arts & Metiers (CNAM);
   Universite Paris 13; Institut National de la Sante et de la Recherche
   Medicale (Inserm); Assistance Publique Hopitaux Paris (APHP); Hopital
   Universitaire Avicenne - APHP; CHU Grenoble Alpes; Communaute Universite
   Grenoble Alpes; Universite Grenoble Alpes (UGA); Institut National de la
   Sante et de la Recherche Medicale (Inserm); Communaute Universite
   Grenoble Alpes; Universite Grenoble Alpes (UGA); University of Sydney;
   George Institute for Global Health; Universite de Toulouse; Universite
   Toulouse III - Paul Sabatier; Institut National de la Sante et de la
   Recherche Medicale (Inserm)
RP Czernichow, S (corresponding author), Univ Paris 13, CNAM, INRA, Nutr Epidemiol Res Unit,UMR U557,INSERM,U1125,CRN, 74 Rue Marcel Cachin, F-93017 Bobigny, France.
EM czernichow@uren.smbh.univ-paris13.fr
RI Huxley, Rachel/C-7032-2013; Favier, Adrien/IST-6122-2023; Huxley,
   Rachel/J-4638-2013; Galan, Pilar/F-2908-2017; HERCBERG,
   SERGE/F-3038-2017
OI Gueranger, Anne-Claire/0000-0003-0728-9313; Huxley,
   Rachel/0000-0002-2705-6616; Galan, Pilar/0000-0003-1706-3107; HERCBERG,
   SERGE/0000-0002-3168-1350
FU National Ethical Committee [706]
FX The SU.VI.MAX Study was approved by the National Ethical Committee
   CCPPRB number 706).
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NR 42
TC 127
Z9 130
U1 1
U2 17
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0002-9165
EI 1938-3207
J9 AM J CLIN NUTR
JI Am. J. Clin. Nutr.
PD AUG 1
PY 2009
VL 90
IS 2
BP 329
EP 335
DI 10.3945/ajcn.2009.27635
PG 7
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 472SI
UT WOS:000268152000013
PM 19491388
OA Green Submitted, Bronze
DA 2025-06-11
ER

PT J
AU Fargion, S
   Porzio, M
   Fracanzani, AL
AF Fargion, Silvia
   Porzio, Marianna
   Fracanzani, Anna Ludovica
TI Nonalcoholic fatty liver disease and vascular disease: State-of-the-art
SO WORLD JOURNAL OF GASTROENTEROLOGY
LA English
DT Article
DE Intima-media thickness; Steatosis; Nonalcoholic fatty liver disease;
   Non-alcoholic steatohepatitis; Early atherosclerosis; Cardiovascular
   risk; Inflammation; Epicardic fat
ID INTIMA-MEDIA THICKNESS; EPICARDIAL ADIPOSE-TISSUE; CHRONIC
   KIDNEY-DISEASE; OBSTRUCTIVE SLEEP-APNEA; SUBCLINICAL
   CARDIOVASCULAR-DISEASE; INCREASED ARTERIAL STIFFNESS;
   GAMMA-GLUTAMYL-TRANSFERASE; INDEPENDENT RISK-FACTOR; TERM-FOLLOW-UP;
   CAROTID ATHEROSCLEROSIS
AB Nonalcoholic fatty liver disease (NAFLD), the most common of chronic liver disease in Western Country, is closely related to insulin resistance and oxidative stress and includes a wide spectrum of liver diseases ranging from steatosis alone, usually a benign and non-progressive condition, to nonalcoholic steatohepatitis (NASH), which may progress to liver fibrosis and cirrhosis. NAFLD is considered the hepatic manifestation of the metabolic syndrome with which shares several characteristics, however recent data suggest that NAFLD is linked to increased cardiovascular risk independently of the broad spectrum of risk factors of metabolic syndrome. Accumulating evidence suggests that the clinical burden of NAFLD is not restricted to liver-related morbidity and mortality, with the majority of deaths in NAFLD patients related to cardiovascular disease and cancer and not to the progression of liver disease. Retrospective and prospective studies provide evidence of a strong association between NAFLD and subclinical manifestation of atherosclerosis (increased intima-media thickness, endothelial dysfunction, arterial stiffness, impaired left ventricular function and coronary calcification). A general agreement emerging from these studies indicates that patients with NASH are at higher risk of cardiovascular diseases than those with simple steatosis, emphasizing the role of chronic inflammation in the pathogenesis of atherosclerosis of these patients. It is very likely that the different mechanisms involved in the pathogenesis of atherosclerosis in patients with NAFLD have a different relevance in the patients according to individual genetic background. In conclusion, in the presence of NAFLD patients should undergo a complete cardiovascular evaluation to prevent future atherosclerotic complications. Specific lifestyle modification and aggressive pharmaceutical modification will not only reduce the progression of liver disease, but also reduce morbidity for cardiovascular disease improving overall prognosis and survival. (C) 2014 Baishideng Publishing Group Inc. All rights reserved.
C1 [Fargion, Silvia; Porzio, Marianna; Fracanzani, Anna Ludovica] Ca Granda IRCCS Fdn, Policlin Hosp Pad Granelli, Metab Liver Dis Res Ctr, Dept Pathophysiol & Transplantat, I-20122 Milan, Italy.
C3 IRCCS Ca Granda Ospedale Maggiore Policlinico
RP Fargion, S (corresponding author), Ca Granda IRCCS Fdn, Policlin Hosp Pad Granelli, Metab Liver Dis Res Ctr, Dept Pathophysiol & Transplantat, Via F Sforza 35, I-20122 Milan, Italy.
EM silvia.fargion@unimi.it
RI Fracanzani, Anna Ludovica/J-8986-2018
OI Fracanzani, Anna Ludovica/0000-0001-5918-0171
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NR 157
TC 166
Z9 171
U1 1
U2 15
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 7041 Koll Center Parkway, Suite 160, PLEASANTON, CA, UNITED STATES
SN 1007-9327
EI 2219-2840
J9 WORLD J GASTROENTERO
JI World J. Gastroenterol.
PD OCT 7
PY 2014
VL 20
IS 37
BP 13306
EP 13324
DI 10.3748/wjg.v20.i37.13306
PG 19
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA AR9GN
UT WOS:000343881200011
PM 25309067
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Mattei, J
   Demissie, S
   Falcon, LM
   Ordovas, JM
   Tucker, K
AF Mattei, Josiemer
   Demissie, Serkalem
   Falcon, Luis M.
   Ordovas, Jose M.
   Tucker, Katherine
TI Allostatic load is associated with chronic conditions in the Boston
   Puerto Rican Health Study
SO SOCIAL SCIENCE & MEDICINE
LA English
DT Article
DE Allostatic load; Health disparities; Puerto Ricans; Chronic diseases;
   Metabolic syndrome; USA
ID CUMULATIVE BIOLOGICAL RISK; C-REACTIVE PROTEIN; FOOD FREQUENCY
   QUESTIONNAIRE; NON-HISPANIC WHITE; NEUROENDOCRINE BIOMARKERS; SEX
   DIFFERENTIALS; PHYSICAL-ACTIVITY; US ADULTS; STRESS; DISEASE
AB Puerto Ricans living in the United States mainland present multiple disparities in prevalence of chronic diseases, relative to other racial and ethnic groups. Allostatic load (AL), or the cumulative wear and tear of physiological responses to stressors such as major life events, social and environmental burden, has been proposed as a possible mechanism for the inequalities observed in minority groups, but has not been studied in Puerto Ricans. The aim of this study was to determine the association of AL to six chronic diseases (abdominal obesity, hypertension, diabetes, and self-reported cardiovascular disease (CVD), arthritis and cancer) in Puerto Ricans, and to contrast AL to metabolic syndrome (MetS). Participants of the Boston Puerto Rican Health Study (n = 1116, ages 45-75 years) underwent a home-based interview, where questionnaires were completed and biological samples collected. A summary definition of AL was constructed using clinically-defined cutoffs and medication use for 10 physiological parameters in different body systems. Logistic regression models were run to determine associations between AL score and disease status, controlling for age, sex, smoking, alcohol use, physical activity, total fat intake and energy intake. Parallel models were also run with MetS score replacing AL We found that increasing categories of AL score were significantly associated with abdominal obesity, hypertension, diabetes and self-reported cardiovascular disease (CVD) and arthritis, but not with self-reported cancer. The strength of associations of AL with all conditions, except diabetes and cancer, was similar to or larger than those of MetS score. In conclusion, Puerto Rican older adults experienced physiological dysregulation that was associated with increased odds of chronic conditions. AL was more strongly associated with most conditions, compared to MetS, suggesting that this cumulative measure may be a better predictor of disease. These results have prospective research implications for Puerto Ricans and other ethnic groups. (C) 2010 Elsevier Ltd. All rights reserved.
C1 [Tucker, Katherine] Northeastern Univ, Dept Hlth Sci, Boston, MA 02115 USA.
   [Mattei, Josiemer; Ordovas, Jose M.; Tucker, Katherine] Tufts Univ, Boston, MA 02111 USA.
   [Demissie, Serkalem] Boston Univ, Boston, MA 02215 USA.
C3 Northeastern University; Tufts University; Boston University
RP Tucker, K (corresponding author), Northeastern Univ, Dept Hlth Sci, 316 Robinson Hall, Boston, MA 02115 USA.
EM kl.tucker@neu.edu
RI Tucker, Katherine/A-4545-2010; Falcon, Luis/C-1237-2009; Mattei,
   Josiemer/H-1800-2016; Ordovas, Jose/B-8727-2013
OI Demissie, Serkalem/0000-0002-8009-0987; Mattei,
   Josiemer/0000-0001-5424-8245; Tucker, Katherine/0000-0001-7640-662X;
   Ordovas, Jose/0000-0002-7581-5680; Falcon, Luis M./0000-0002-2476-5046
FU NHLBI NIH HHS [T32 HL069772] Funding Source: Medline; NIA NIH HHS
   [P01-AG023394, P01-AG023394-S1, P01 AG023394] Funding Source: Medline
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NR 81
TC 154
Z9 194
U1 0
U2 27
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0277-9536
J9 SOC SCI MED
JI Soc. Sci. Med.
PD JUN
PY 2010
VL 70
IS 12
BP 1988
EP 1996
DI 10.1016/j.socscimed.2010.02.024
PG 9
WC Public, Environmental & Occupational Health; Social Sciences, Biomedical
WE Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; Biomedical Social Sciences
GA 608HL
UT WOS:000278574300017
PM 20381934
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Girerd, N
   Pibarot, P
   Fournier, D
   Daleau, P
   Voisine, P
   O'Hara, G
   Després, JP
   Mathieu, P
AF Girerd, Nicolas
   Pibarot, Philippe
   Fournier, Dominique
   Daleau, Pascal
   Voisine, Pierre
   O'Hara, Gilles
   Despres, Jean-Pierre
   Mathieu, Patrick
TI Middle-aged men with increased waist circumference and elevated
   C-reactive protein level are at higher risk for postoperative atrial
   fibrillation following coronary artery bypass grafting surgery
SO EUROPEAN HEART JOURNAL
LA English
DT Article
DE Postoperative atrial fibrillation; Metabolic syndrome; Coronary artery
   bypass grafting; Abdominal obesity; Waist circumference; C-reactive
   protein
ID CARDIAC-SURGERY; CARDIOVASCULAR-DISEASE; OBESITY; PREVENTION;
   INFLAMMATION; PREDICTORS; MECHANISMS; TISSUE
AB We recently demonstrated that metabolic syndrome (MetS) is an independent risk factor for postoperative atrial fibrillation (POAF) following coronary artery bypass grafting (CABG). In the present work, we sought to determine which feature of the MetS is associated with POAF.
   We retrospectively analysed the association between metabolic features and the incidence of new-onset POAF in a total of 2214 male patients < 65 years who underwent first isolated CABG. Anthropometric data including waist circumference (WC) and complete preoperative lipid profile were available. We also conducted a nested case-control substudy including 147 patients who developed POAF, and were matched for age with a control population. In these patients, C-reactive protein, interleukin-6 (IL-6), and thiobarbituric acid-reactive substances (TBARS; evaluating the oxidative stress) blood levels were determined. In the whole cohort, 19.6% of patients developed POAF. On univariate analysis, body mass index (BMI; P = 0.002) and WC (P = 0.001) were the only anthropometric variables significantly associated with increased incidence of POAF. In the multivariable logistic model, the only independent predictors of POAF were a WC > 102 cm [odds ratio (OR) = 1.40, P = 0.04)] and older age (OR = 1.08, P < 0.001). In the nested case-control substudy C-reactive protein, IL-6, and TBARS levels were not significantly different in patients with or without POAF. Of particular significance, patients with elevated WC > 102 cm and C-reactive protein > 1.5 mg/L or IL-6 > 2.2 pg/mL were at a high risk of developing POAF (respectively, OR = 2.32, P = 0.02 and OR = 2.27, P = 0.03).
   Patients with increased WC combined with elevated C-reactive protein levels are at higher risk for POAF. Thus, interventions targeting inflammation related to visceral obesity might help reducing the incidence of POAF.
C1 [Fournier, Dominique; Voisine, Pierre; Mathieu, Patrick] Univ Laval, Dept Surg, Ste Foy, PQ G1V 4G5, Canada.
   [Girerd, Nicolas; Pibarot, Philippe; Daleau, Pascal; O'Hara, Gilles] Univ Laval, Dept Med, Ste Foy, PQ G1V 4G5, Canada.
   [Despres, Jean-Pierre] Univ Laval, Dept Social & Prevent Med, Ste Foy, PQ G1V 4G5, Canada.
C3 Laval University; Laval University; Laval University
RP Mathieu, P (corresponding author), Univ Laval, Dept Surg, 2725 Chemin Ste Foy, Ste Foy, PQ G1V 4G5, Canada.
EM patrick.mathieu@chg.ulaval.ca
RI Pibarot, Philippe/ABD-5300-2021; Daleau, Pascal/W-4941-2019; GIRERD,
   Nicolas/D-5493-2011
OI Girerd, Nicolas/0000-0002-3278-2057
FU Quebec Heart Institute Foundation, Quebec, Canada; Reseau d'Echange de
   Tissus et Echantillons Biologiques; Fonds de Recherche en Sante du
   Quebec, Montreal, Canada; International Chair on Cardiometabolic Risk at
   Universite Laval; Sanofi-Aventis awarded to Universite Laval; Fonds de
   Recherche en Santedu Quebec, Montreal, Canada
FX This work was supported by the Quebec Heart Institute Foundation,
   Quebec, Canada, and the Reseau d'Echange de Tissus et Echantillons
   Biologiques, Fonds de Recherche en Sante du Quebec, Montreal, Canada. Dr
   P. P. holds the Canada Research Chair in Valvular Heart Diseases,
   Canadian Institutes of Health Research, Ottawa, Ontario, Canada. Dr
   J.-P.D. is the scientific director of the International Chair on
   Cardiometabolic Risk at Universite Laval, which is supported by an
   unrestricted grant from Sanofi-Aventis awarded to Universite Laval. Dr
   P. M. is a research scholar from the Fonds de Recherche en Santedu
   Quebec, Montreal, Canada. N.G. had full access to all of the data in the
   study and takes responsibility for the integrity of the data and the
   accuracy of the data analysis.
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NR 34
TC 73
Z9 77
U1 0
U2 2
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0195-668X
EI 1522-9645
J9 EUR HEART J
JI Eur. Heart J.
PD MAY
PY 2009
VL 30
IS 10
BP 1270
EP 1278
DI 10.1093/eurheartj/ehp091
PG 9
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 446IL
UT WOS:000266115200020
PM 19329496
OA Bronze
DA 2025-06-11
ER

PT J
AU Banaszak, M
   Dobrzynska, M
   Kawka, A
   Górna, I
   Wozniak, D
   Przyslawski, J
   Drzymala-Czyz, S
AF Banaszak, Michalina
   Dobrzynska, Malgorzata
   Kawka, Anna
   Gorna, Ilona
   Wozniak, Dagmara
   Przyslawski, Juliusz
   Drzymala-Czyz, Slawomira
TI Role of Omega-3 fatty acids eicosapentaenoic (EPA) and docosahexaenoic
   (DHA) as modulatory and anti-inflammatory agents in noncommunicable
   diet-related diseases - Reports from the last 10 years
SO CLINICAL NUTRITION ESPEN
LA English
DT Review
DE PUFA; Type 2 diabetes; Obesity; Cardiovascular diseases; Nonalcoholic
   fatty liver disease; Metabolic syndrome
ID POLYUNSATURATED FATTY-ACIDS; FISH-OIL; CARDIOVASCULAR-DISEASE;
   INFLAMMATORY PROCESSES; METABOLIC SYNDROME; GLYCEMIC CONTROL; LIPID
   PROFILE; DOUBLE-BLIND; SUPPLEMENTATION; OMEGA-3
AB Background & aims: Fatty acids are a fundamental component of the human diet, particularly polyunsaturated fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). The importance of omega-3 fatty acids has been studied in the context of many diseases due to their pleiotropic effects, focusing on the anti-inflammatory effects of EPA and DHA. Currently, the results of these acids in noncommunicable diseases are being increasingly assessed in a broader context than just inflammation. However, the mechanisms underlying the modulatory and anti-inflammatory effects of omega-3 fatty acids remain the subject of intensive research. Therefore, we reviewed the literature covering articles from the last decade to assess not only the anti-inflammatory but, above all, the modulatory effect of EPA and DHA acids on noncommunicable diet-related diseases. Methods: The PubMed, Web of Science and Scopus databases were searched for studies regarding the effects of omega-3 fatty acids on diet-related disorders from the last 10 years. Results: The available research shows that EPA and DHA supplementation has a beneficial impact on regulating triglycerides, total cholesterol, insulin resistance, blood pressure, liver enzymes, inflammatory markers and oxidative stress. Additionally, there is evidence of their potential benefits in terms of mitochondrial function, regulation of plasma lipoproteins, and reduction of the risk of sudden cardiovascular events associated with atherosclerotic plaque rupture. Conclusions: Omega-3 polyunsaturated fatty acids (EPA, DHA) have many beneficial effects among patients with diet-related disorders. More well-designed randomised controlled trials are needed to fully determine the usefulness of EPA and DHA in treating and preventing noncommunicable diet-related diseases. (c) 2024 The Author(s). Published by Elsevier Ltd on behalf of European Society for Clinical Nutrition and Metabolism. This is an open access article under the CC BY license (http://creativecommons.org/licenses/ by/4.0/).
C1 [Banaszak, Michalina; Dobrzynska, Malgorzata; Gorna, Ilona; Wozniak, Dagmara; Przyslawski, Juliusz; Drzymala-Czyz, Slawomira] Poznan Univ Med Sci, Dept Bromatol, Rokietnicka 3, Poznan, Poland.
   [Banaszak, Michalina] Poznan Univ Med Sci, Doctoral Sch, Bukowska 70, Poznan, Poland.
   [Kawka, Anna] Adam Mickiewicz Univ, Fac Chem, Dept Bioact Prod, Uniwersytetu Poznanskiego 8, Poznan, Poland.
C3 Poznan University of Medical Sciences; Poznan University of Medical
   Sciences; Adam Mickiewicz University
RP Banaszak, M (corresponding author), Poznan Univ Med Sci, Dept Bromatol, Rokietnicka 3, Poznan, Poland.
EM michalina.banaszak@student.ump.edu.pl
RI Górna, Ilona/Y-1707-2019
OI Kawka, Anna/0000-0001-9281-7103; Gorna, Ilona/0000-0002-9652-0785;
   Banaszak, Michalina/0000-0003-2771-0769
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NR 98
TC 28
Z9 29
U1 9
U2 18
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2405-4577
J9 CLIN NUTR ESPEN
JI Clin. Nutr. ESPEN
PD OCT
PY 2024
VL 63
BP 240
EP 258
DI 10.1016/j.clnesp.2024.06.053
EA JUL 2024
PG 19
WC Nutrition & Dietetics
WE Emerging Sources Citation Index (ESCI)
SC Nutrition & Dietetics
GA YI0X2
UT WOS:001267753200001
PM 38980796
OA hybrid
DA 2025-06-11
ER

PT J
AU Baratta, F
   Cammisotto, V
   Tozzi, G
   Coronati, M
   Bartimoccia, S
   Castellani, V
   Nocella, C
   D'Amico, A
   Angelico, F
   Carnevale, R
   Pignatelli, P
   Del Ben, M
AF Baratta, Francesco
   Cammisotto, Vittoria
   Tozzi, Giulia
   Coronati, Mattia
   Bartimoccia, Simona
   Castellani, Valentina
   Nocella, Cristina
   D'Amico, Alessandra
   Angelico, Francesco
   Carnevale, Roberto
   Pignatelli, Pasquale
   Del Ben, Maria
TI High Compliance to Mediterranean Diet Associates with Lower Platelet
   Activation and Liver Collagen Deposition in Patients with Nonalcoholic
   Fatty Liver Disease
SO NUTRIENTS
LA English
DT Article
DE nonalcoholic fatty liver disease; Mediterranean diet; platelet activity;
   liver fibrosis; cardiovascular risk; thromboxane; Pro-C3
ID METABOLIC SYNDROME; OXIDATIVE STRESS; ADHERENCE; FIBROSIS;
   THROMBOXANE-A2; CONSUMPTION; PREVALENCE; MECHANISMS; MANAGEMENT;
   SEVERITY
AB The Mediterranean diet (Med-Diet) is considered the most effective dietary patterns to obtain weight loss in NAFLD patients. Previous evidence suggested that Med-Diet adherence could reduce cardiovascular risk and have a beneficial effect on NAFLD severity. Aim of the study was to investigate the relationship between Med-Diet adherence, platelet activation (PA), and liver collagen deposition. The study was performed in 655 consecutive NAFLD outpatients from the PLINIO study, a prospective observational cohort study aimed to identify non-conventional predictors of liver fibrosis progression in NAFLD. PA was measured by the serum thromboxane B-2 (TxB(2)), and liver collagen deposition by N-terminal propeptide of type III collagen (Pro-C3). Adherence to the Med-diet was investigated by a short nine-item validated dietary questionnaire. Patients with high Med-Diet adherence were older and had less metabolic syndrome and lower serum triglycerides, GGT, TxB(2), and Pro-C3. At multivariate regression analyses, in the linear model, the Med-Diet score negatively correlated with both TxB(2) (Beta = -0.106; p = 0.009) and Pro-C3 (Beta = -0.121; p = 0.002) and in the logistic model high adherence inversely correlated with higher TxB(2) tertiles (II tertile: OR = 0.576, p = 0.044; III tertile: OR = 0.556, p = 0.026) and Pro-C3 tertile (III tertile: OR = 0.488, p = 0.013). Low consumption of red meat inversely correlated with higher TxB(2) tertile (II tertile: OR = 0.448, p < 0.001, III tertile: OR = 0.567, p = 0.004). In conclusion, NAFLD patients with high adherence to the Med-Diet show lower PA and liver collagen deposition, suggesting a protective role of the Med-Diet against NAFLD progression and cardiovascular risk. In addition, the correlation between TxB(2) and Pro-C3 suggests a link between NAFLD severity and cardiovascular risk.
C1 [Baratta, Francesco; Cammisotto, Vittoria; Coronati, Mattia; Nocella, Cristina; Pignatelli, Pasquale; Del Ben, Maria] Sapienza Univ Rome, Dept Clin Internal Anaesthesiol & Cardiovasc Sci, I-00161 Rome, Italy.
   [Tozzi, Giulia] IRCCS Bambino Gesu Childrens Hosp, Dept Pediat, Div Metab, I-00146 Rome, Italy.
   [Tozzi, Giulia] IRCCS Bambino Gesu Childrens Hosp, Dept Pediat, Res Unit Metab Biochem, I-00146 Rome, Italy.
   [Bartimoccia, Simona; Carnevale, Roberto] Sapienza Univ Rome, Dept Med Surg Sci & Biotechnol, I-04100 Latina, Italy.
   [Castellani, Valentina] Sapienza Univ Rome, Dept Gen Surg & Surg Special Paride Stefanini, I-00161 Rome, Italy.
   [D'Amico, Alessandra] Univ Rome Foro Italico, Dept Movement Human & Hlth Sci, I-00135 Rome, Italy.
   [Angelico, Francesco] Sapienza Univ Rome, Dept Publ Hlth & Infect Dis, I-00161 Rome, Italy.
   [Carnevale, Roberto; Pignatelli, Pasquale] Mediterranea Cardioctr, I-80122 Naples, Italy.
C3 Sapienza University Rome; IRCCS Bambino Gesu; IRCCS Bambino Gesu;
   Sapienza University Rome; Sapienza University Rome; Foro Italico
   University of Rome; Sapienza University Rome
RP Baratta, F (corresponding author), Sapienza Univ Rome, Dept Clin Internal Anaesthesiol & Cardiovasc Sci, I-00161 Rome, Italy.
EM francesco.baratta@uniroma1.it; vittoria.cammisotto@uniroma1.it;
   giulia.tozzi@opbg.net; mattia.coronati@gmail.com;
   simona.bartimoccia@uniroma1.it; valentina.castellani@uniroma1.it;
   cristina.nocella@uniroma1.it; a.damico@studenti.uniroma4.it;
   francesco.angelico@uniroma1.it; roberto.carnevale@uniroma1.it;
   pasquale.pignatelli@uniroma1.it; maria.delben@uniroma1.it
RI D'Amico, Alessandra/IUN-1943-2023; Nocella, Cristina/K-2175-2016;
   Carnevale, Roberto/JMC-1138-2023; Angelico, Francesco/AAB-6585-2020;
   Tozzi, Giulia/K-8605-2018; Del Ben, Maria/AAE-7603-2020; pignatelli,
   pasquale/K-2116-2016; Bartimoccia, Simona/K-7873-2016; Carnevale,
   Roberto/K-1472-2016
OI DEL BEN, MARIA/0000-0003-1199-8454; Baratta,
   Francesco/0000-0003-1708-272X; D'Amico, Alessandra/0000-0002-5571-4583;
   pignatelli, pasquale/0000-0002-2265-7455; Cammisotto,
   Vittoria/0000-0003-1966-5945; Castellani, Valentina/0000-0001-6455-4828;
   Coronati, Mattia/0000-0003-0052-1378; Bartimoccia,
   Simona/0000-0002-6266-3059; Carnevale, Roberto/0000-0002-6216-9595
FU Sapienza - University of Rome
FX This research received no external funding, APC was founded by Sapienza
   - University of Rome.
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NR 62
TC 5
Z9 6
U1 0
U2 4
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD MAR
PY 2022
VL 14
IS 6
AR 1209
DI 10.3390/nu14061209
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 0B0NC
UT WOS:000774339700001
PM 35334864
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Caimi, G
   Hopps, E
   Montana, M
   Urso, C
   Carollo, C
   Canino, B
   Lo Presti, R
AF Caimi, Gregorio
   Hopps, Eugenia
   Montana, Maria
   Urso, Caterina
   Carollo, Caterina
   Canino, Baldassare
   Lo Presti, Rosalia
TI The function of matrix metalloproteinase-9 (MMP-9) and its tissue
   inhibitor (TIMP-1) in several clinical conditions: Results and analysis
   of our survey
SO CLINICAL HEMORHEOLOGY AND MICROCIRCULATION
LA English
DT Article
DE MMP-9; TIMP-1; obesity; metabolic syndrome; preclinical carotid
   atherosclerosis; OSAS; CKD
ID CHRONIC KIDNEY-DISEASE; MATRIX METALLOPROTEINASE-2 AND-9; SLEEP-APNEA;
   OXIDATIVE STRESS; OVERWEIGHT PATIENTS; ADIPOSE-TISSUE; OBESE CHILDREN;
   WEIGHT-LOSS; MARKERS; PLASMA
AB The goal of this research was to evaluate the plasma concentration of MMP-9 and its tissue inhibitor (TIMP-1) in different clinical conditions. It included several groups of subjects: 31 overweight subjects; 91 obese adults divided into two subgroups according to the BMI value (BMI 30-35 Kg/m2 and BMI> 35 Kg/m(2)); 90 subjects with metabolic syndrome (MS) divided into two subgroups (with and without diabetes mellitus); 100 subjects with preclinical carotid atherosclerosis (PCA) divided according to the number of cardiovascular risk factors and to the insulin resistance degree; 48 subjects with obstructive sleep apnoea syndrome (OSAS) divided according to the apnoea/hypopnea index (AHI); 27 subjects with chronic kidney disease (CKD) on conservative management; 31 subjects with CKD on regular haemodialysis treatment. We have found a significant increase of MMP-9 and TIMP-1 in overweight subjects, in obese adult and in MS subjects. In obese adults, the behaviour of these two parameters was not influenced by the degree of obesity, while in the group of MS subjects both these parameters were clearly influenced by the presence of diabetes mellitus. In subjects with PCA, we observed an increase of MMP-9 associated with a significant decrease of TIMP-1; the same trend was found by subdividing the entire group in accordance with the number of cardiovascular risk factors and with the insulin resistance degree. In subjects with OSAS, we noted an increase in MMP-9 and TIMP-1; this increase was more evident in subjects with OSAS having AHI >30. In individuals with CKD on conservative and haemodialysis treatment we have found, at baseline, a marked increase in MMP-9 and a significant decrease of TIMP-1. In dialyzed subjects, after a standard dialysis session was noted, a significant increase in MMP-9 was associated with a further decrease in TIMP-1.
C1 [Caimi, Gregorio; Hopps, Eugenia; Montana, Maria; Carollo, Caterina; Canino, Baldassare] Univ Palermo, Dept Hlth Promot Mother & Child Care, Internal Med & Med Specialties, Palermo, Italy.
   [Urso, Caterina] Fdn Ist G Giglio, Cefalu, Italy.
   [Lo Presti, Rosalia] Univ Palermo, Dept Psychol Educ Sci & Human Movement, Palermo, Italy.
C3 University of Palermo; University of Palermo
RP Caimi, G (corresponding author), Via Leonardo Vinci 52, I-90145 Palermo, Italy.
EM gregorio.caimi@unipa.it
RI Carollo, Caterina/AAT-3063-2021; Montaña, Fernanda/ADG-6031-2022;
   Presti, Rosalia/J-5394-2016
OI CAROLLO, Caterina/0000-0002-6767-8823
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NR 111
TC 9
Z9 10
U1 0
U2 5
PU IOS PRESS
PI AMSTERDAM
PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS
SN 1386-0291
EI 1875-8622
J9 CLIN HEMORHEOL MICRO
JI Clin. Hemorheol. Microcirc.
PY 2021
VL 78
IS 4
BP 401
EP 416
DI 10.3233/CH-201094
PG 16
WC Hematology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Hematology; Cardiovascular System & Cardiology
GA UZ2HV
UT WOS:000702032100006
PM 33814420
DA 2025-06-11
ER

PT J
AU Fernández-Rodríguez, CM
   Aller, R
   Gutiérrez-García, ML
   Ampuero, J
   Gómez-Camarero, J
   Martín-Mateos, RM
   Burgos-Santamaría, D
   Rosales, JM
   Aspichueta, P
   Buque, X
   Latorre, M
   Andrade, RJ
   Hernández-Guerra, M
   Romero-Gómez, M
AF Fernandez-Rodriguez, Conrado M.
   Aller, Rocio
   Luisa Gutierrez-Garcia, Ma
   Ampuero, Javier
   Gomez-Camarero, Judith
   Martin-Mateos, Rosa M.
   Burgos-Santamaria, Diego
   Miguel Rosales, Jose
   Aspichueta, Patricia
   Buque, Xabier
   Latorre, Mercedes
   Andrade, Raul J.
   Hernandez-Guerra, Manuel
   Romero-Gomez, Manuel
TI Higher levels of serum uric acid influences hepatic damage in patients
   with non-alcoholic fatty liver disease (NAFLD)
SO REVISTA ESPANOLA DE ENFERMEDADES DIGESTIVAS
LA English
DT Article
DE Serum uric acid; NAFLD; NASH
ID METABOLIC SYNDROME; CELL-PROLIFERATION; OXIDATIVE STRESS; DANGER
   SIGNALS; URATE OXIDASE; HYPERTENSION; ASSOCIATION; STEATOHEPATITIS;
   HYPERURICEMIA; INFLAMMASOME
AB Background: recent evidence suggests a causal link between serum uric acid and the metabolic syndrome, diabetes mellitus, arterial hypertension, and renal and cardiac disease. Uric acid is an endogenous danger signal and activator of the inflammasome, and has been independently associated with an increased risk of cirrhosis.
   Aim and methods: six hundred and thirty-four patients from the nation-wide HEPAMET registry with biopsy-proven NAFLD (53% NASH) were analyzed to determine whether hyperuricemia is related with advanced liver damage in patients with non-alcoholic fatty liver disease (NAFLD). Patients were divided into three groups according to the tertile levels of serum uric acid and gender.
   Results: the cohort was composed of 50% females, with a mean age of 49 years (range 19-80). Patients in the top third of serum uric acid levels were older (p = 0.017); they had a higher body mass index (p < 0.01), arterial blood pressure (p = 0.05), triglyceridemia (p = 0.012), serum creatinine (p < 0.001) and total cholesterol (p = 0.016) and lower HDL-cholesterol (p = 0.004). According to the univariate analysis, the variables associated with patients in the top third were more advanced steatosis (p = 0.02), liver fibrosis (F2-F4 vs F0-1; p = 0.011), NASH (p = 0.002) and NAS score (p = 0.05). According to the multivariate logistic regression analysis, the top third of uric acid level was independently associated with steatosis (adjusted hazard ratio 1.7; CI 95%: 1.05-2.8) and NASH (adjusted hazard ratio 1.8; CI 95%: 1.08-3.0) but not with advanced fibrosis (F2-F4) (adjusted hazard ratio 1.09; CI 95%: 0.63-1.87).
   Conclusion: higher levels of serum uric acid were independently associated with hepatocellular steatosis and NASH in a cohort of patients with NAFLD. Serum uric acid levels warrants further evaluation as a component of the current non-invasive NAFLD scores of histopathological damage.
C1 [Fernandez-Rodriguez, Conrado M.; Luisa Gutierrez-Garcia, Ma] Hosp Univ Fdn Alcorcon, Digest Dis Unit, Av Budapest 1, Madrid 28922, Spain.
   [Aller, Rocio] Hosp Clin, Valladolid, Spain.
   [Ampuero, Javier; Romero-Gomez, Manuel] Hosp Univ Virgen del Rocio, Unit Clin Management Digest Dis, Seville, Spain.
   [Ampuero, Javier; Romero-Gomez, Manuel] IBIS, CIBERehd, Madrid, Spain.
   [Gomez-Camarero, Judith] Hosp Univ, Burgos, Spain.
   [Martin-Mateos, Rosa M.; Burgos-Santamaria, Diego] Univ Alcala de Henares, Hosp Univ Ramon & Cajal, Madrid, Spain.
   [Martin-Mateos, Rosa M.; Burgos-Santamaria, Diego; Miguel Rosales, Jose; Andrade, Raul J.; Romero-Gomez, Manuel] CIBERehd, Madrid, Spain.
   [Miguel Rosales, Jose] Agencia Sanitaria Costa del Sol Marbella, Unit Gastroenterol, Malaga, Spain.
   [Aspichueta, Patricia; Buque, Xabier] Univ Basque Country, UPV EHU, Biocruces Hlth Res Inst, Bizkaia, Spain.
   [Latorre, Mercedes] Hosp Gen Univ Consortium, Valencia, Spain.
   [Andrade, Raul J.] Univ Malaga, Inst Biol IBIMA, Hosp Univ Virgen Victoria, Malaga, Spain.
   [Hernandez-Guerra, Manuel] Hosp Univ Tenerife, Canary Isl, Spain.
   [Romero-Gomez, Manuel] Univ Seville, SeLiver Grp, Inst Biomed Sevilla IBIS, Seville, Spain.
C3 Alcorcon Foundation University Hospital; Virgen del Rocio University
   Hospital; CIBER - Centro de Investigacion Biomedica en Red; CIBEREHD;
   University of Sevilla; Hospital Universitario Ramon y Cajal; Universidad
   de Alcala; CIBER - Centro de Investigacion Biomedica en Red; CIBEREHD;
   University of Basque Country; Hospital Virgen de la Victoria; Instituto
   de Investigacion Biomedica de Malaga y Plataforma en Nanomedicina
   (IBIMA); Universidad de Malaga; Consejo Superior de Investigaciones
   Cientificas (CSIC); University of Sevilla; CSIC-JA-USE - Instituto de
   Biomedicina de Sevilla (IBIS)
RP Fernández-Rodríguez, CM (corresponding author), Hosp Univ Fdn Alcorcon, Digest Dis Unit, Av Budapest 1, Madrid 28922, Spain.
EM cfernandez@fhalcorcon.es
RI Martin Mateos, Rosa/H-7308-2019; Fernández-Rodríguez,
   Concepción/G-8592-2011; ALLER, ROCIO/JXM-2497-2024; Hernandez-Guerra,
   Manuel/AFB-8988-2022; Ampuero, Javier/AAI-2582-2019; Romero-Gomez,
   Manuel/L-8030-2014; Rosales-Zabal, Jose Miguel/Q-7170-2018; Aspichueta,
   Patricia/M-3490-2018
OI Romero-Gomez, Manuel/0000-0001-8494-8947; Hernandez-Guerra,
   Manuel/0000-0002-3478-9981; Fernandez Rodriguez, Conrado
   M/0000-0002-1915-2157; Rosales-Zabal, Jose Miguel/0000-0001-6751-6720;
   Aspichueta, Patricia/0000-0002-3553-1755; Martin-Mateos,
   Rosa/0000-0001-5874-211X
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NR 38
TC 20
Z9 21
U1 0
U2 14
PU ARAN EDICIONES, S A
PI MADRID
PA CASTELLO, 128, 28006 MADRID, SPAIN
SN 1130-0108
EI 2340-4167
J9 REV ESP ENFERM DIG
JI Rev. Esp. Enferm. Dig.
PY 2019
VL 111
IS 4
BP 264
EP 269
DI 10.17235/reed.2019.5965/2018
PG 6
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA HR7LR
UT WOS:000463336100003
PM 30810330
OA gold
DA 2025-06-11
ER

PT J
AU Omori, S
   Uchida, F
   Oh, S
   So, R
   Tsujimoto, T
   Yanagawa, T
   Sakai, S
   Shoda, J
   Tanaka, K
   Bukawa, H
AF Omori, Shoei
   Uchida, Fumihiko
   Oh, Sechang
   So, Rina
   Tsujimoto, Takehiko
   Yanagawa, Toru
   Sakai, Satoshi
   Shoda, Junichi
   Tanaka, Kiyoji
   Bukawa, Hiroki
TI Exercise habituation is effective for improvement of periodontal disease
   status: a prospective intervention study
SO THERAPEUTICS AND CLINICAL RISK MANAGEMENT
LA English
DT Article
DE bacteria; intervention studies; lifestyle; metabolic syndrome; obesity;
   periodontal disease; periodontal status
ID METABOLIC SYNDROME; PHYSICAL-ACTIVITY; OXIDATIVE STRESS; ADIPOSE-TISSUE;
   INFLAMMATION; ASSOCIATION; OBESITY; RISK; OVERWEIGHT/OBESITY;
   ADIPOCYTOKINES
AB Background and purpose: Periodontal disease is closely related to lifestyle-related diseases and obesity. It is widely known that moderate exercise habits lead to improvement in lifestyle-related diseases and obesity. However, little research has been undertaken into how exercise habits affect periodontal disease. The purpose of this study was to examine the effect of exercise habits on periodontal diseases and metabolic pathology.
   Methods: We conducted a prospective intervention research for 12 weeks. The subjects were 71 obese men who participated in an exercise and/or dietary intervention program. Fifty subjects were assigned to exercise interventions (exercise intervention group) and 21 subjects were assigned to dietary interventions (dietary intervention group). This research was conducted before and after each intervention program.
   Results: In the exercise intervention group the number of teeth with a probing pocket depth (PPD) >= 4 mm significantly decreased from 14.4% to 5.6% (P < 0.001), and the number of teeth with bleeding on probing (BOP) significantly decreased from 39.8% to 14.4% (P < 0.001). The copy counts of Tannerella forsythia and Treponema denticola decreased significantly (P=0.001). A positive correlation was found between the change in the copy count of T. denticola and the number of teeth with PPD >= 4 mm (P=0.003) and the number of teeth with BOP (P=0.010). A positive correlation was also found between the change in the copy count of T. denticola and body weight (P=0.008), low-density lipoprotein cholesterol (P=0.049), and fasting insulin (P=0.041). However, in the dietary intervention group the copy count of T. denticola decreased significantly (P=0.007) and there was no correlation between the number of periodontal disease-causing bacteria and PPD and BOP.
   Conclusion: Our results are the first to show that exercise might contribute to improvements in periodontal disease.
C1 [Omori, Shoei] Univ Tsukuba, Grad Sch Comprehens Human Sci, Oral & Maxillofacial Surg Clin Sci, Tsukuba, Ibaraki, Japan.
   [Omori, Shoei] Kitaibaraki City Hosp, Dept Dent Oral Surg, Kitaibaraki, Ibaraki, Japan.
   [Uchida, Fumihiko] Univ Tsukuba Hosp, Dept Oral & Maxillofacial Surg, 1-1-1 Tennodai, Tsukuba, Ibaraki 3058575, Japan.
   [Oh, Sechang; Sakai, Satoshi; Shoda, Junichi] Univ Tsukuba, Fac Med, Dept Med Sci, Tsukuba, Ibaraki, Japan.
   [Oh, Sechang; Shoda, Junichi] Tsukuba Univ Hosp, Ctr Sports Med & Hlth Sci, Tsukuba, Ibaraki, Japan.
   [So, Rina] Natl Inst Occupat Safety & Hlth, Res Ctr Overwork Related Disorders, Kawasaki, Kanagawa, Japan.
   [Tsujimoto, Takehiko] Shimane Univ, Fac Human Sci, Dept Sports Med, Matsue, Shimane, Japan.
   [Yanagawa, Toru; Bukawa, Hiroki] Univ Tsukuba, Fac Med, Dept Oral & Maxillofacial Surg, Tsukuba, Ibaraki, Japan.
   [Tanaka, Kiyoji] Univ Tsukuba, Fac Hlth & Sport Sci, Dept Sports Med, Tsukuba, Ibaraki, Japan.
C3 University of Tsukuba; University of Tsukuba; University of Tsukuba;
   University of Tsukuba; Shimane University; University of Tsukuba;
   University of Tsukuba
RP Uchida, F (corresponding author), Univ Tsukuba Hosp, Dept Oral & Maxillofacial Surg, 1-1-1 Tennodai, Tsukuba, Ibaraki 3058575, Japan.
EM uchiyamada1031@yahoo.co.jp
RI Oh, Sechang/AAV-5502-2020; Tsujimoto, Takehiko/AAD-4458-2022; Yanagawa,
   Toru/GYU-6448-2022
OI Tsujimoto, Takehiko/0000-0003-3187-5689; Yanagawa,
   Toru/0000-0003-0868-2563
FU Ministry of Education, Culture, Sports, Science and Technology, Japan
   [26293284, 15K15037, 16H03255, 15H04917, 17H02174]; Grants-in-Aid for
   Scientific Research [16H03255, 15K15037, 15H04917, 17K19888, 26293284,
   16H05220, 17H02174] Funding Source: KAKEN
FX We would like to thank Mr Takashi Shida and Dr Takehito Terabe for
   analysis and interpretation of data and Dr Kenji Yamagata and Naomi
   Ishibasi-Kanno for advice and guidance. This work was supported in part
   by Grants-in-Aid for Scientific Research from the Ministry of Education,
   Culture, Sports, Science and Technology, Japan (numbers 26293284,
   15K15037, 16H03255, 15H04917, and 17H02174).
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NR 51
TC 23
Z9 26
U1 2
U2 10
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
EI 1178-203X
J9 THER CLIN RISK MANAG
JI Therap. Clin. Risk Manag.
PY 2018
VL 14
BP 565
EP 574
DI 10.2147/TCRM.S153397
PG 10
WC Health Care Sciences & Services
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Health Care Sciences & Services
GA GA1DA
UT WOS:000428054500001
PM 29593415
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Wysokinski, A
   Kloszewska, I
AF Wysokinski, Adam
   Kloszewska, Iwona
TI Uric acid levels in patients with schizophrenia on clozapine monotherapy
SO NORDIC JOURNAL OF PSYCHIATRY
LA English
DT Article
DE Clozapine; Metabolic syndrome; Schizophrenia; Uric acid
ID X-RAY ABSORPTIOMETRY; OXIDATIVE STRESS; METABOLIC SYNDROME;
   BODY-COMPOSITION; DOUBLE-BLIND; OLANZAPINE; PLACEBO; MANIA; ADOLESCENTS;
   ZOTEPINE
AB Background. We tested the hypothesis that uric acid levels are higher in subjects with schizophrenia treated with clozapine than in healthy control and they correlate with anthropometric measurements, laboratory tests and results of bioimpedance analysis of body composition. Methods. Data for 24 subjects with schizophrenia treated with clozapine and 24 age- and sex-matched healthy volunteers was analyzed. Results. There was no difference of fasting uric acid concentrations between clozapine and control groups (4.5 +/- 1.4 vs. 4.3 +/- 1.3 mg/dl, P = 0.87). Regarding the whole group, uric acid levels were significantly higher in men (5.2 +/- 1.2 vs. 3.6 +/- 0.9, P < 0.001). Uric acid levels correlated with weight (R = 0.58, P = 0.003), body mass index (BMI; R = 0.49, P = 0.01), abdominal circumference (R = 0.45, P = 0.03), waist circumference (R = 0.47, P = 0.02), waist-to-hip ratio (R = 0.42, P = 0.04), insulin (R = 0.50, P = 0.01), homoeostasis model assessment of insulin resistance 2 (HOMA2-IR; R = 0.49, P = 0.01), basal metabolic rate (R = 0.56, P = 0.004), lean body mass (R = 0.55, P = 0.005) and body water (R = 0.55, P = 0.005). There were no significant differences of uric acid levels for smoking status, impaired fasting glucose, abdominal obesity, obesity/overweight and dyslipidemia. Uric acid levels did not correlate with age, duration of clozapine treatment, clozapine dose, leg circumference, systolic blood pressure, diastolic blood pressure, total body fat, triglycerides, total cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL), homocysteine, corrected calcium, glucose and homoeostasis model assessment of insulin resistance 1 (HOMA1-IR). Conclusions. We did not find significant differences in blood uric acid levels between subjects with schizophrenia and controls. Association with weight, BMI, abdominal and waist circumferences, insulin levels and insulin resistance may support uric acid role as an important cardiovascular risk factor. Association with lean weight may explain why men have higher levels of uric acid than women.
C1 [Wysokinski, Adam; Kloszewska, Iwona] Med Univ Lodz, Dept Old Age Psychiat & Psychot Disorders, PL-92216 Lodz, Poland.
C3 Medical University Lodz
RP Wysokinski, A (corresponding author), Med Univ Lodz, Dept Old Age Psychiat & Psychot Disorders, Czechoslowacka 8-10, PL-92216 Lodz, Poland.
EM adam.wysokinski@gmail.com
RI Wysokinski, Adam/S-9294-2016; Wysokinski, Adam/G-8174-2014
OI Wysokinski, Adam/0000-0002-6159-6579
FU Healthy Ageing Research Centre [REGPOT-2012-2013-1]
FX The authors are (partially) supported by Healthy Ageing Research Centre
   (REGPOT-2012-2013-1, 7FP).
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NR 31
TC 6
Z9 6
U1 0
U2 8
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0803-9488
EI 1502-4725
J9 NORD J PSYCHIAT
JI Nord. J. Psychiatr.
PD AUG 18
PY 2015
VL 69
IS 6
BP 1735
EP 1740
DI 10.3109/08039488.2014.1002420
PG 6
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA CY3HT
UT WOS:000366300600006
PM 25801748
DA 2025-06-11
ER

PT J
AU Kahl, KG
   Fraccarollo, D
   Winter, L
   Bauersachs, J
   Westhoff-Bleck, M
AF Kahl, Kai G.
   Fraccarollo, Daniela
   Winter, Lotta
   Bauersachs, Johann
   Westhoff-Bleck, Mechthild
TI Increased epicardial adipose tissue in young adults with congenital
   heart disease comorbid with major depressive disorder
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Adult congenital heart disease; Major depressive disorder; Epicardial
   adipose tissue
ID MYOCARDIAL-INFARCTION; PROGNOSTIC ASSOCIATION; CARDIOVASCULAR EVENTS;
   ARTERIAL-HYPERTENSION; MEDICATION ADHERENCE; SEDENTARY BEHAVIOR;
   METABOLIC SYNDROME; PHYSICAL-ACTIVITY; LIFE-SPAN; MORTALITY
AB Objective: Congenital heart disease is the most common congenital malformation. In adult congenital heart disease (ACHD), the prevalence of major depressive disorder (MDD) is increased. Beyond its immanent health risks, increased epi- and paracardial adipose tissue has been described in MDD. Epicardial adipose tissue (EAT) is a fat depot surrounding the heart, and it is hypothesized to be associated with coronary artery disease, left-ventricular dysfunction and atrial fibrillation, being frequent problems in ACHD long-term management. We here examined whether EAT is increased in depressed patients with ACHD.
   Methods: Two-hundred and ten ACHD outpatients (mean age 35.5y, 43% female) were included. MDD was diagnosed according to DSM-IV criteria using expert interviews. EAT was measured using echocardiography. Further assessments comprised NT-proBNP, left and right ventricular end-diastolic diameter, left-ventricular ejection fraction, smoking behavior and physical activity.
   Results: Of 210 patients, 53 (25.2%) were diagnosed with MDD. EAT was increased in depressed ACHD (F = 5.04; df = 1; p = 0.026). Depressed male patients were less physically active (p < 0.05) and smoked more cigarettes (p < 0.05). EAT was positively predicted by depression severity (p = 0.039), body mass index (p < 0.001), and negatively predicted by physical activity (p = 0.019).
   Conclusions: The presence of MDD is associated with an increased amount of EAT in ACHD, and is dependent on depression severity. Further, the amount of EAT is at least in part mediated by a more sedentary lifestyle. Given the long-term health risks associated with increased EAT, interventions aiming at increased physical activity, smoking cessation and early identification of comorbid MDD may be recommended in ACHD.
C1 [Kahl, Kai G.; Winter, Lotta] Hannover Med Sch, Dept Psychiat Social Psychiat & Psychotherapy, Hannover, Germany.
   [Fraccarollo, Daniela; Bauersachs, Johann; Westhoff-Bleck, Mechthild] Hannover Med Sch, Adult Congenital Heart Ctr, Dept Cardiol & Angiol, Hannover, Germany.
C3 Hannover Medical School; Hannover Medical School
RP Kahl, KG (corresponding author), Hannover Med Sch, Dept Psychiat Social Psychiat & Psychotherapy, Hannover, Germany.
EM kahl.kai@mh-hannover.de
RI Bauersachs, Johann/AFT-4329-2022
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NR 65
TC 6
Z9 6
U1 2
U2 3
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD OCT 1
PY 2019
VL 257
BP 678
EP 683
DI 10.1016/j.jad.2019.07.070
PG 6
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA IS8CQ
UT WOS:000482376300085
PM 31377604
DA 2025-06-11
ER

PT J
AU Gonzalez, JM
   Thompson, PM
   Moore, TA
AF Gonzalez, Jodi M.
   Thompson, Peter M.
   Moore, Troy A.
TI Review of the safety, efficacy, and side effect profile of asenapine in
   the treatment of bipolar 1 disorder
SO PATIENT PREFERENCE AND ADHERENCE
LA English
DT Review
DE asenapine; antipsychotic; adherence; acceptability; metabolic syndrome
ID PLACEBO-CONTROLLED TRIAL; DOUBLE-BLIND TRIAL; ACUTE MANIA;
   MENTAL-ILLNESS; MIXED STATES; I-DISORDER; ADHERENCE; INDIVIDUALS;
   SCHIZOPHRENIA; RISPERIDONE
AB Objective: Asenapine is approved for acute manic and mixed states in bipolar disorder. The objective is to review the efficacy of asenapine in bipolar disorder, with a particular focus on acceptability and adherence to treatment.
   Methods: Five clinical trials were conducted in bipolar disorder manic or mixed states: two 3-week trials (n = 976) comparing asenapine to placebo, a 9-week extension (n = 504), and a 40-week extension (n = 107). One trial was conducted comparing asenapine to placebo (n = 326) as adjunctive therapy for subjects with an incomplete response to lithium or valproate. All trials were conducted in the USA and internationally.
   Results: Asenapine was found to be efficacious for manic and mixed states in bipolar disorder compared with placebo control, and compares equally well to olanzapine on efficacy measures after 3 weeks of treatment. Asenapine was not found to be efficacious for depression symptoms. Common asenapine side effects in the 40-week extension trial were sedation, insomnia, and dizziness, and 31% reported clinically significant weight gain, compared with 55% reporting clinically significant weight gain with olanzapine. Additionally, 18% had clinically significant changes in fasting blood glucose levels compared to 22% of those on olanzapine. In terms of patient acceptability, one concern may be sublingual administration requiring no liquids or food for 10 minutes after dosing and a twice-daily regimen. Suggestions about addressing barriers to adherence and acceptability are provided.
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C1 [Gonzalez, Jodi M.; Thompson, Peter M.; Moore, Troy A.] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA.
C3 University of Texas System; University of Texas Health Science Center at
   San Antonio
RP Gonzalez, JM (corresponding author), 7703 Floyd Curl Dr, San Antonio, TX 78229 USA.
EM gonzalezjm1@uthscsa.edu
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NR 39
TC 24
Z9 25
U1 0
U2 5
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1177-889X
J9 PATIENT PREFER ADHER
JI Patient Prefer. Adherence
PY 2011
VL 5
BP 333
EP 341
DI 10.2147/PPA.S10968
PG 9
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA 889FR
UT WOS:000300059500001
PM 21792304
OA gold, Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Jalali, N
   Khalili, P
   Jamali, Z
   Jalali, Z
   Moghadam-Ahmadi, A
   Vakilian, A
   Ayoobi, F
AF Jalali, Nazanin
   Khalili, Parvin
   Jamali, Zahra
   Jalali, Zahra
   Moghadam-Ahmadi, Amir
   Vakilian, Alireza
   Ayoobi, Fatemeh
TI Sleep duration, hypnotic drug use, and risk factors: cross- sectional
   study
SO SCIENTIFIC REPORTS
LA English
DT Article
ID METABOLIC SYNDROME; METAANALYSIS; POPULATION; MORTALITY; CANCER; GENDER;
   HEALTH; ASSOCIATIONS; DISTURBANCE; DEPRESSION
AB Both short sleep duration (SSD) and long sleep duration (LSD) are associated with an increased risk of morbidity and mortality. Here, we aimed to assess the prevalence of sleep duration disturbances among adults in association with demographic, medication use, personal habits, and chronic diseases, while also considering the impact of hypnotic drug use. We performed a cross-sectional study of 9991 adult participants of the Rafsanjan Cohort Study (RCS), as part of the Prospective epidemiological research studies in Iran (PERSIAN). Multivariate logistic regression analyses were conducted to assess the association between short (< 6 h) and long (> 9 h) sleep duration with demographic and lifestyle parameters and common non-communicable diseases. Additionally, we performed stratified analysis to investigate the association of sleep duration with the abovementioned factors and diseases, in groups with and without hypnotic drug use. We found higher odds of SSD significantly associated with age (P < 0.001), BMI (P < 0.001), physical activity (P < 0.001), and depression (P = 0.023). LSD displayed a positive association with the female sex (P < 0.001), opium consumption (P < 0.001), and history of MI (P = 0.045), and a reverse connection with education (P = 0.007), physical activity (P < 0.001) and alcohol consumption (P = 0.027). Stratifying for the hypnotic drug use, our sensitivity analyses indicated that in hypnotic drug users, education (P = 0.034) and physical activity (P < 0.001) were associated with LSD, in this group, significantly increased odds ratio of LSD were associated with opium consumption (P = 0.046) and thyroid dysfunction (P = 0.037). Our findings demonstrated the demographic and lifestyle factors and diseases associated with long and short sleep duration in the population of the RCS. Additionally, after stratifying for hypnotic drug use, our results indicated that some diseases are only associated with abnormal sleep duration upon using hypnotic drugs.
C1 [Jalali, Nazanin; Jalali, Zahra; Vakilian, Alireza] Rafsanjan Univ Med Sci, Noncommunicable Dis Res Ctr, Rafsanjan, Iran.
   [Jalali, Nazanin; Moghadam-Ahmadi, Amir; Vakilian, Alireza] Rafsanjan Univ Med Sci, Sch Med, Neurol Dept, Rafsanjan, Iran.
   [Khalili, Parvin] Rafsanjan Univ Med Sci, Social Determinants Hlth Res Ctr, Rafsanjan, Iran.
   [Khalili, Parvin] Rafsanjan Univ Med Sci, Sch Publ Hlth, Dept Epidemiol, Rafsanjan, Iran.
   [Jamali, Zahra] Rafsanjan Univ Med Sci, Niknafs Hosp, Clin Res Dev Unit CRDU, Rafsanjan, Iran.
   [Jalali, Zahra] Rafsanjan Univ Med Sci, Sch Med, Dept Clin Biochem, Rafsanjan, Iran.
   [Moghadam-Ahmadi, Amir] Thomas Jefferson Univ, Jefferson Hosp Neurosci, Neurol Res Lab, Philadelphia, PA USA.
   [Ayoobi, Fatemeh] World Safety Org, Occupat Safety & Hlth Res Ctr, NICICO, Rafsanjan, Iran.
   [Ayoobi, Fatemeh] Rafsanjan Univ Med Sci, Rafsanjan, Iran.
C3 Thomas Jefferson University
RP Ayoobi, F (corresponding author), World Safety Org, Occupat Safety & Hlth Res Ctr, NICICO, Rafsanjan, Iran.; Ayoobi, F (corresponding author), Rafsanjan Univ Med Sci, Rafsanjan, Iran.
EM ayoobi.fatemeh@gmail.com
RI Jalali, Zahra/D-7293-2019; khalili, parvin/ABA-5170-2021;
   Moghadam-Ahmadi, Amir/U-8275-2017; Jalali, Nazanin/I-5030-2017; ayoobi,
   fatemeh/B-7036-2019; Jamali, Zahra/ABA-2457-2021; Vakilian,
   Alireza/A-4106-2011
OI Jalali, Zahra/0000-0002-3808-5658; Vakilian,
   Alireza/0000-0001-5413-5400; jamali, Zahra/0000-0002-7705-431X
FU Iranian Ministry of Health and Medical Education [700/534]
FX The authors thank the people who participated in the study, the
   study-site personnel, and the Rafsanjan cohort center members in
   Rafsanjan, Iran. The Iranian Ministry of Health and Medical Education
   has contributed to the funding used in the PERSIAN Cohort through Grant
   no 700/534.
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NR 65
TC 0
Z9 0
U1 0
U2 5
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD MAR 1
PY 2023
VL 13
IS 1
AR 3459
DI 10.1038/s41598-023-30501-6
PG 10
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA G9DN6
UT WOS:000992078000065
PM 36859460
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU George, SK
   Tlou, B
   Ponnusamy, S
   Naidoo, DP
AF George, Sunil K.
   Tlou, Boikhutso
   Ponnusamy, Somalingum
   Naidoo, Datshana P.
TI Does acid reflux precipitate ischaemia in subjects with acute coronary
   syndrome?
SO CARDIOVASCULAR JOURNAL OF AFRICA
LA English
DT Article
DE reflux oesophagitis; ischaemia; chest pain
ID CARDIO-ESOPHAGEAL REFLEX; GASTROESOPHAGEAL-REFLUX; CHEST-PAIN; LINKED
   ANGINA; PROGNOSTIC-SIGNIFICANCE; MYOCARDIAL-INFARCTION; PRACTICE
   GUIDELINES; DISEASE; CONSTRICTION; ASSOCIATION
AB Aim: It has been postulated that gastro-oesophageal reflux disease (GORD) may trigger coronary ischaemia through viscerocardiac reflex vasoconstriction in subjects with ischaemic heart disease (IHD). Our aim was to estimate the prevalence of GORD in subjects with IHD who present with acute coronary syndrome (ACS) and to determine whether GORD may serve as a trigger for ischaemic events.
   Methods: Twenty patients with isolated reflux oesophagitis and 39 with acute coronary syndrome (ACS with concomitant GORD) were studied. Twenty-two subjects comprising normal volunteers and those who were admitted for minor surgical trauma were used as normal controls. All subjects underwent oesophago-gastroduodenal endoscopy (EGD) and acid instillation with hydrochloric acid (0.1 M), as well as nuclear imaging (sestaMIBI) with technetium(99). Ischaemia was detected by ST depression using ECG monitoring for one hour during and immediately after EGD.
   Results: Of the 111 subjects with ACS, 39 (35.1%) had erosive GORD and comprised the study group. Subjects with ACS had more incidence of diabetes (p = 0.001), hypertension (p = 0.002), a history of smoking (p = 0.006) and elevated serum triglyceride levels (p = 0.008) compared to the GORD group. Risk-factor clustering in the form of the metabolic syndrome was more common in ACS subjects (44 vs 5%; p = 0.008). ST depression was documented in 8/39 (20.5%) patients in the ACS group and 5/20 (25%) in the GORD group (p = 0.958). Reversible perfusion defects on sestaMIBI scan were seen in 35.6% of the ACS subjects.
   Conclusion: Although GORD is common in subjects with ACS, we have not been able to show that GORD may serve as a trigger for ischaemia in these subjects.
C1 [George, Sunil K.; Ponnusamy, Somalingum; Naidoo, Datshana P.] Univ KwaZulu Natal, Nelson R Mandela Sch Med, Dept Cardiol, Durban, South Africa.
   [Tlou, Boikhutso] Univ KwaZulu Natal, Sch Nursing & Publ Hlth, Discipline Publ Hlth Med, Durban, South Africa.
C3 University of Kwazulu Natal; University of Kwazulu Natal
RP Naidoo, DP (corresponding author), Univ KwaZulu Natal, Nelson R Mandela Sch Med, Dept Cardiol, Durban, South Africa.
EM naidood@ukzn.ac.za
RI TLOU, BOIKHUTSO/AEA-3161-2022; GEORGE, SUNIL/JCD-5133-2023
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NR 43
TC 0
Z9 0
U1 0
U2 1
PU CLINICS CARDIVE PUBL PTY LTD
PI DURBANVILLE
PA PO BOX 1013, DURBANVILLE, 7551, SOUTH AFRICA
SN 1995-1892
EI 1680-0745
J9 CARDIOVASC J AFR
JI Cardiovasc. J. Afr.
PD MAR-APR
PY 2020
VL 31
IS 2
BP 65
EP 70
DI 10.5830/CVJA-2019-048
PG 6
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA NW9FU
UT WOS:000575321200003
PM 31591635
DA 2025-06-11
ER

PT J
AU Novelli, M
   Masiello, P
   Beffy, P
   Menegazzi, M
AF Novelli, Michela
   Masiello, Pellegrino
   Beffy, Pascale
   Menegazzi, Marta
TI Protective Role of St. John's Wort and Its Components Hyperforin and
   Hypericin against Diabetes through Inhibition of Inflammatory Signaling:
   Evidence from In Vitro and In Vivo Studies
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE St. John's wort; hyperforin; hypericin; cytokines; inflammatory
   signaling; pancreatic beta cells; diabetes; obesity; metabolic syndrome;
   insulin resistance
ID NF-KAPPA-B; PREGNANE X RECEPTOR; SPATIAL MEMORY IMPAIRMENTS;
   NITRIC-OXIDE SYNTHASE; NONSTEROIDAL ANTIINFLAMMATORY DRUGS;
   ENDOPLASMIC-RETICULUM STRESS; P-GLYCOPROTEIN EXPRESSION;
   SPINAL-CORD-INJURY; BETA-CELL DEATH; HIGH-FAT-DIET
AB Diabetes mellitus is a very common chronic disease with progressively increasing prevalence. Besides the well-known autoimmune and inflammatory pathogenesis of type 1 diabetes, in many people, metabolic changes and inappropriate lifestyle favor a subtle chronic inflammatory state that contributes to development of insulin resistance and progressive loss of beta-cell function and mass, eventually resulting in metabolic syndrome or overt type 2 diabetes. In this paper, we review the anti-inflammatory effects of the extract of Hypericum perforatum L. (St. John's wort, SJW) and its main active ingredients firstly in representative pathological situations on inflammatory basis and then in pancreatic beta cells and in obese or diabetic animal models. The simultaneous and long-lasting inhibition of signal transducer and activator of transcription (STAT)-1, nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappa B) and mitogen-activated protein kinases (MAPKs)/c-jun N-terminal kinase (JNK) signaling pathways involved in pro-inflammatory cytokine-induced beta-cell dysfunction/death and insulin resistance make SJW particularly suitable for both preventive and therapeutic use in metabolic diseases. Hindrance of inflammatory cytokine signaling is likely dependent on the hyperforin content of SJW extract, but recent data reveal that hypericin can also exert relevant protective effects, mediated by activation of the cyclic adenosine monophosphate (cAMP)/protein kinase cAMP-dependent (PKA)/adenosine monophosphate activated protein kinase (AMPK) pathway, against high-fat-diet-induced metabolic abnormalities. Actually, the mechanisms of action of the two main components of SJW appear complementary, strengthening the efficacy of the plant extract. Careful quantitative analysis of SJW components and suitable dosage, with monitoring of possible drug-drug interaction in a context of remarkable tolerability, are easily achievable pre-requisites for forthcoming clinical applications.
C1 [Novelli, Michela; Masiello, Pellegrino] Univ Pisa, Sch Med, Dept Translat Res & New Technol Med & Surg, I-56126 Pisa, Italy.
   [Beffy, Pascale] CNR, Inst Clin Physiol, I-56124 Pisa, Italy.
   [Menegazzi, Marta] Univ Verona, Sch Med, Dept Neurosci Biomed & Movement Sci, Biochem Sect, I-37134 Verona, Italy.
C3 University of Pisa; Consiglio Nazionale delle Ricerche (CNR); Istituto
   di Fisiologia Clinica (IFC-CNR); University of Verona
RP Novelli, M; Masiello, P (corresponding author), Univ Pisa, Sch Med, Dept Translat Res & New Technol Med & Surg, I-56126 Pisa, Italy.
EM michela.novelli@med.unipi.it; pellegrino.masiello@med.unipi.it;
   p.beffy@gmail.com; marta.menegazzi@univr.it
RI Menegazzi, Marta/AAE-7079-2019
OI menegazzi, marta/0000-0003-1310-9227
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NR 225
TC 35
Z9 37
U1 1
U2 31
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD NOV
PY 2020
VL 21
IS 21
AR 8108
DI 10.3390/ijms21218108
PG 35
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA OR0JI
UT WOS:000589161100001
PM 33143088
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Abdel-Moneim, A
   Mahmoud, B
   Sultan, EA
   Mahmoud, R
AF Abdel-Moneim, Adel
   Mahmoud, Basant
   Sultan, Eman A.
   Mahmoud, Rania
TI Association of erythrocytes indices and interleukin-1 beta with
   metabolic syndrome components
SO UNIVERSITY OF TORONTO MEDICAL JOURNAL
LA English
DT Article
ID CELL DISTRIBUTION WIDTH; OXIDATIVE STRESS; BLOOD-VISCOSITY;
   HEMATOLOGICAL PARAMETERS; INSULIN-RESISTANCE; INFLAMMATION; RISK;
   ADOLESCENTS; IMPACT; HEMATOCRIT
AB Background: The relationship between hematological studies and cytokines arc of great importance in metabolic syndrome (MetS) pathophysiologry. The study aimed to illuminate the association between red blood cell RBC) indices and interleukin-1-beta (IL-1 beta) with MetS components among adult Egyptian patients.
   Methods: A total of 100 healthy subjects and 200 patients diagnosed with MctS components were enrolled in the study. MetS patients have at least three of the following MetS components: abdominal obesity, hypertriglyceridemia, low high-density lipoprotein levels, hypertension, and hyperglycemia. Eligible patients were classified into 4 groups of 50 patients each. Group I included patients with 2 MetS criteria, Group 2 patients met 3 MetS criteria, Group 3 patients had 4 MetS criteria, and Group 4 patients fulfilled all 5 MetS criteria. Patients in Groups 2 to 4 arc considered MetS patients, while those in Group 1 an classified as being at risk of MetS.
   Results: Among MetS patients, the data disclosed significantly (p<0.001) elevated RBC count and hematocrit percentage (HTC%) in Groups 2 and 3. However, higher hemoglobin (HB) content and elevated mean corpuscular volume values were recorded in Group 3 compared to healthy controls. Group 4 had noticeably lower RBC count and HB level compared to healthy controls. Moreover, values of red blood cell distribution width and IL-1 beta were significantly higher (p<0.001) in all MetS patient groups compared to the healthy group. The continuous MetS score showed a graded significant (p<0.001) elevation with the increase in MetS components. Concerning Group 3, RBC count recorded positive correlations with systolic blood pressure and IL-1 beta values, while red cell distribution width percentage (RDW%) was correlated with the homeostatic' model assessment of insulin resistance (HOMA-IR) in Groups 3 and 4.
   Conclusions: Erythrocyte profile, IL-1 beta, and continuous MetS score values were associated with the increase in MetS components. The study provides additional evidence to use hematological and cytokine biomarkers as well as continuous MetS score values in early identification of individuals at risk of MetS.
C1 [Abdel-Moneim, Adel] Beni Suef Univ, Fac Sci, Mol Physiol Div, Bani Suwayf, Egypt.
   [Mahmoud, Basant; Mahmoud, Rania] Beni Suef Univ, Fac Sci, Biochem Dept, Bani Suwayf, Egypt.
   [Sultan, Eman A.] Natl Nutr Inst, Endocrinol & Metab Dept, Cairo, Egypt.
C3 Egyptian Knowledge Bank (EKB); Beni Suef University; Egyptian Knowledge
   Bank (EKB); Beni Suef University
RP Abdel-Moneim, A (corresponding author), Beni Suef Univ, Fac Sci, Mol Physiol Div, Bani Suwayf, Egypt.
EM adel_men2020@yahoo.com
CR Abdel-Moneim A, 2019, MALAYS J MED SCI, V26, P47, DOI 10.21315/mjms2019.26.4.6
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NR 44
TC 1
Z9 1
U1 0
U2 0
PU UNIV TORONTO, MEDICAL SOC
PI TORONTO
PA STUDENT RUN, MEDICAL SCIENCES BLDG, RM 2171A, 1 KINGS COLLEGE CIRCLE,
   TORONTO, ON M5S 1A8, CANADA
SN 0833-2207
EI 1913-5440
J9 UNIV TOR MED J
JI Univ. Tor. Med. J.
PD JAN
PY 2020
VL 97
IS 1
BP 6
EP 13
PG 8
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA KE6LY
UT WOS:000508666800001
DA 2025-06-11
ER

PT J
AU Kosola, J
   Vaara, JP
   Ahotupa, M
   Kyröläinen, H
   Santtila, M
   Oksala, N
   Atalay, M
   Vasankari, T
AF Kosola, Jussi
   Vaara, Jani P.
   Ahotupa, Markku
   Kyrolainen, Heikki
   Santtila, Matti
   Oksala, Niku
   Atalay, Mustafa
   Vasankari, Tommi
TI Elevated concentration of oxidized LDL together with poor
   cardiorespiratory and abdominal muscle fitness predicts metabolic
   syndrome in young men
SO METABOLISM-CLINICAL AND EXPERIMENTAL
LA English
DT Article
DE Oxidized LDL lipids; Tumor necrosis factor alpha; Interleukin-6; Maximal
   oxygen uptake; Muscle fitness
ID LOW-DENSITY-LIPOPROTEIN; TYPE-2 DIABETES-MELLITUS; TIME
   PHYSICAL-ACTIVITY; C-REACTIVE PROTEIN; INSULIN-RESISTANCE; OXIDATIVE
   STRESS; POSTMENOPAUSAL WOMEN; WAIST CIRCUMFERENCE; PLASMA-LEVELS; OBESE
   ADULTS
AB Background. Metabolic syndrome (MetS) is associated with increased oxidized LDL (ox-LDL), systemic inflammation, and poor cardiorespiratory fitness. We examined affiliations of these factors and the effect of muscular fitness on MetS in young healthy men.
   Methods. Physical fitness, ox-LDL, tumor necrosis factor alpha (TNF alpha), interleukin-6 (IL-6) and serum lipids were measured in a nationally representative sample of Finnish young men with and without MetS. Participants (mean age 25.1 years) performed tests of maximal oxygen uptake (VO(2)max) and muscle fitness, and were divided into MetS (n=54, IDF 2007 criteria) and non-MetS (n=790). Age, smoking and leisure-time physical activity were used as covariates (ANCOVA).
   Results. The MetS group had lower results in VO(2)max and all of the muscular fitness tests (excluding grip strength) (P<0.0001, in all). Ox-LDL, ox-LDL/HDL-cholesterol, ox-LDL/LDL-cholesterol, TNF alpha and IL-6 were all higher in the MetS group than in the non-MetS group (P<0.01, in all). In stepwise multivariate logistic regression analysis (adjusted to MetS criteria), higher ox-LDL (OR 1.118, 95% CI 1.078-1.160), lower VO(2)max (OR 0.938, 95% CI 0.901-0.977) and lower sit-ups (OR 0.898, 95% CI 0.844-0.956) predicted MetS (p<0.05, in all).
   Conclusions. Young men with MetS possess significantly poorer cardiorespiratory and muscle fitness, together with elevated systemic levels of ox-LDL, TNF alpha and IL-6 compared to non-MetS young men. Of these variables, ox-LDL, VO(2)max and sit-ups predicted MetS. Based on these findings, poor physical fitness and elevated concentration of ox-LDL are significant predisposing factors in the development of MetS. (C) 2013 Elsevier Inc. All rights reserved.
C1 [Kosola, Jussi] Univ Turku, Dept Physiol, Dept Hlth & Exercise, FIN-20520 Turku, Finland.
   [Kosola, Jussi] Univ Turku, Dept Physiol, Paavo Nurmi Ctr, FIN-20520 Turku, Finland.
   [Kosola, Jussi; Ahotupa, Markku] Univ Turku, Dept Physiol, MCA Res Lab, Turku, Finland.
   [Vaara, Jani P.; Kyrolainen, Heikki] Univ Jyvaskyla, Dept Biol Phys Act, SF-40100 Jyvaskyla, Finland.
   [Vaara, Jani P.; Kyrolainen, Heikki] Natl Def Univ, Dept Leadership & Mil Pedag, Helsinki, Finland.
   [Santtila, Matti] Finnish Def Forces, Personnel Div, Def Command, Helsinki, Finland.
   [Oksala, Niku] Univ Tampere, Dept Surg, Tampere Univ Hosp, FIN-33101 Tampere, Finland.
   [Atalay, Mustafa] Univ Eastern Finland, Inst Biomed, Kuopio, Finland.
   [Vasankari, Tommi] UKK Inst Hlth Promot Res, Tampere, Finland.
   [Vasankari, Tommi] Natl Inst Hlth & Welf, Helsinki, Finland.
C3 University of Turku; University of Turku; University of Turku;
   University of Jyvaskyla; Tampere University; Tampere University
   Hospital; University of Eastern Finland; UKK Institute; Finland National
   Institute for Health & Welfare
RP Kosola, J (corresponding author), Univ Turku, Dept Physiol, Dept Hlth & Exercise, Kiinamyllynkatu 10, FIN-20520 Turku, Finland.
EM jussi.kosola@utu.fi
RI Singh, Ambrish/W-2163-2017; Vaara, Jani/AAC-4613-2020; Oksala,
   Niku/C-5856-2016
OI Oksala, Niku/0000-0001-5336-3719; Kyrolainen, Heikki/0000-0003-3822-1733
FU The Scientific Advisory Board for Defence
FX The present study was supported by The Scientific Advisory Board for
   Defence. We thank biostatistician Elina Kokkonen for her advice and
   expertise in the statistical analysis.
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NR 52
TC 16
Z9 17
U1 0
U2 9
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0026-0495
J9 METABOLISM
JI Metab.-Clin. Exp.
PD JUL
PY 2013
VL 62
IS 7
BP 992
EP 999
DI 10.1016/j.metabol.2013.01.013
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 175IT
UT WOS:000321225100012
PM 23490585
DA 2025-06-11
ER

PT J
AU Nierenberg, AA
   Agustini, B
   Köhler-Forsberg, O
   Cusin, C
   Katz, D
   Sylvia, LG
   Peters, A
   Berk, M
AF Nierenberg, Andrew A.
   Agustini, Bruno
   Kohler-Forsberg, Ole
   Cusin, Cristina
   Katz, Douglas
   Sylvia, Louisa G.
   Peters, Amy
   Berk, Michael
TI Diagnosis and Treatment of Bipolar Disorder A Review
SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
LA English
DT Review
ID WEEKLY SYMPTOMATIC STATUS; TASK-FORCE REPORT; INTERNATIONAL SOCIETY;
   MAINTENANCE TREATMENT; NATURAL-HISTORY; MOOD STABILIZER; DOUBLE-BLIND;
   METAANALYSIS; LITHIUM; EFFICACY
AB IMPORTANCE Bipolar disorder affects approximately 8 million adults in the US and approximately 40 million individuals worldwide.OBSERVATIONS Bipolar disorder is characterized by recurrent episodes of depression and mania or hypomania. Bipolar depressive episodes are similar to major depressive episodes. Manic and hypomanic episodes are characterized by a distinct change in mood and behavior during discrete time periods. The age of onset is usually between 15 and 25 years, and depression is the most frequent initial presentation. Approximately 75% of symptomatic time consists of depressive episodes or symptoms. Early diagnosis and treatment are associated with a more favorable prognosis. Diagnosis and optimal treatment are often delayed by a mean of approximately 9 years following an initial depressive episode. Long-term treatment consists of mood stabilizers, such as lithium, valproate, and lamotrigine. Antipsychotic agents, such as quetiapine, aripiprazole, asenapine, lurasidone, and cariprazine, are recommended, but some are associated with weight gain. Antidepressants are not recommended as monotherapy. More than 50% of patients with bipolar disorder are not adherent to treatment. Life expectancy is reduced by approximately 12 to 14 years in people with bipolar disorder, with a 1.6-fold to 2-fold increase in cardiovascular mortality occurring a mean of 17 years earlier compared with the general population. Prevalence rates of metabolic syndrome (37%), obesity (21%), cigarette smoking (45%), and type 2 diabetes (14%) are higher among people with bipolar disorder, contributing to the risk of early mortality. The annual suicide rate is approximately 0.9% among individuals with bipolar disorder, compared with 0.014% in the general population. Approximately 15% to 20% of people with bipolar disorder die by suicide.CONCLUSIONS AND RELEVANCE Bipolar disorder affects approximately 8 million adults in the US. First-line therapy includes mood stabilizers, such as lithium, anticonvulsants, such as valproate and lamotrigine, and atypical antipsychotic drugs, such as quetiapine, aripiprazole, asenapine, lurasidone, and cariprazine.
C1 [Nierenberg, Andrew A.] Massachusetts Gen Hosp, Dauten Family Ctr Bipolar Treatment Innovat, 50 Staniford St,Suite 580, Boston, MA 02114 USA.
   [Nierenberg, Andrew A.; Kohler-Forsberg, Ole; Katz, Douglas; Sylvia, Louisa G.; Peters, Amy] Massachusetts Gen Hosp, Dauten Family Ctr Bipolar Treatment Innovat, Boston, MA USA.
   [Nierenberg, Andrew A.; Cusin, Cristina; Katz, Douglas; Sylvia, Louisa G.; Peters, Amy] Harvard Med Sch, Boston, MA USA.
   [Agustini, Bruno; Berk, Michael] Deakin Univ, IMPACT Inst Mental & Phys Hlth & Clin Translat, Sch Med, Barwon Hlth, Geelong, Australia.
   [Kohler-Forsberg, Ole] Aarhus Univ Hosp, Dept Affect Disorders, Aarhus, Denmark.
   [Kohler-Forsberg, Ole] Aarhus Univ Hosp, Psychosis Res Unit, Aarhus, Denmark.
   [Kohler-Forsberg, Ole] Aarhus Univ, Dept Clin Med, Aarhus, Denmark.
   [Cusin, Cristina] Massachusetts Gen Hosp, Depress Clin & Res Program, Boston, MA USA.
   [Berk, Michael] Univ Melbourne, Florey Inst Neurosci & Mental Hlth, Natl Ctr Excellence Youth Mental Hlth, Ctr Youth Mental Hlth, Melbourne, Australia.
   [Berk, Michael] Univ Melbourne, Dept Psychiat, Melbourne, Australia.
C3 Harvard University; Harvard University Medical Affiliates; Massachusetts
   General Hospital; Harvard University; Harvard University Medical
   Affiliates; Massachusetts General Hospital; Harvard University; Harvard
   Medical School; Deakin University; Aarhus University; Aarhus University;
   Aarhus University; Harvard University; Harvard University Medical
   Affiliates; Massachusetts General Hospital; University of Melbourne;
   Florey Institute of Neuroscience & Mental Health; Orygen, The National
   Centre of Excellence in Youth Mental Health; University of Melbourne
RP Nierenberg, AA (corresponding author), Massachusetts Gen Hosp, Dauten Family Ctr Bipolar Treatment Innovat, 50 Staniford St,Suite 580, Boston, MA 02114 USA.
EM anierenberg@mgh.harvard.edu
RI Cusin, Cristina/O-3358-2018; Nierenberg, ANierenberg/IAR-5549-2023;
   Berk, Michael/AGH-9427-2022; Sylvia, Louisa/AAE-8027-2022
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NR 82
TC 129
Z9 135
U1 35
U2 109
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 0098-7484
EI 1538-3598
J9 JAMA-J AM MED ASSOC
JI JAMA-J. Am. Med. Assoc.
PD OCT 10
PY 2023
VL 330
IS 14
BP 1370
EP 1380
DI 10.1001/jama.2023.18588
PG 11
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA EY8K0
UT WOS:001142586300027
PM 37815563
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Najibi, N
   Firoozi, R
   Shahrezaee, S
   Eshraghian, M
   Daneshi-Maskooni, M
   Dorosty-Motlagh, A
AF Najibi, Narjes
   Firoozi, Roya
   Shahrezaee, Shaghayegh
   Eshraghian, Mohammadreza
   Daneshi-Maskooni, Milad
   Dorosty-Motlagh, Ahmadreza
TI Food insecurity is an important risk factor for type 2 diabetes: a
   case-control study of new referrals to the University clinics, Shiraz,
   Southern Iran
SO BMC PUBLIC HEALTH
LA English
DT Article
DE Food insecurity; Socioeconomic factors; Type 2 diabetes; Iran
ID IMPAIRED FASTING GLUCOSE; NUTRITION EXAMINATION SURVEY; NATIONAL-HEALTH;
   MARITAL-STATUS; NONCOMMUNICABLE DISEASES; METABOLIC SYNDROME; POPULATION
   SURVEY; SECURITY STATUS; LIFE-STYLE; PREVALENCE
AB BackgroundThe prevalence of food insecurity (FI) as the limited or uncertain availability of enough food for an always active and healthy life and diabetes as the most common metabolic disease are rising in Iran. The aim was to assess the FI, depression, and socioeconomic status as risk factors for type 2 diabetes (T2D).MethodsThis case-control study was conducted on 135 patients with T2D as cases (99 females, 36 males, mean age 46.83years) and 135 subjects without diabetes (89 females, 46 males, mean age 45.93years) as controls. They had been referred to clinics of Shiraz University of Medical Sciences, Shiraz, Iran. The prior major inclusion criterion for diabetes was fasting blood sugar (FBS) >= 126mg/dl. General, demographic, and socioeconomic characteristics and FI status were assessed using the general and 18-items United States Department of Agriculture (USDA) household food security questionnaires, respectively. Chi-square, t-test, and uni-and multi-variate logistic regression tests and SPSS16 statistical software were used.ResultsThe prevalence of FI was 66.7% in cases and 41.5% in controls. According to final analysis model, FI (Odds Ratio [OR]=1.9, P=0.016), depression (OR=2.0, P=0.018), body mass index (BMI)>= 25kg/m(2) (OR=1.8, P=0.025), number of children >= 4 (OR=1.7, P=0.046), and having children under 18years. (OR=2.1, P=0.011) were significant independent risk factors for T2D.ConclusionThe prevalence of FI in patients with T2D was significantly higher compared to the controls. FI was an important risk factor for T2D, even after controlling for the potential confounders. Further studies are suggested.
C1 [Najibi, Narjes; Dorosty-Motlagh, Ahmadreza] Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Community Nutr, Tehran, Iran.
   [Firoozi, Roya; Shahrezaee, Shaghayegh] Varastegan Inst Med Sci, Dept Nutr Sci, Mashhad, Razavi Khorasan, Iran.
   [Eshraghian, Mohammadreza] Univ Tehran Med Sci, Sch Publ Hlth, Dept Biostat & Epidemiol, Tehran, Iran.
   [Daneshi-Maskooni, Milad] Jiroft Univ Med Sci, Sch Med, Kerman, Iran.
C3 Tehran University of Medical Sciences; Tehran University of Medical
   Sciences
RP Dorosty-Motlagh, A (corresponding author), Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Community Nutr, Tehran, Iran.; Daneshi-Maskooni, M (corresponding author), Jiroft Univ Med Sci, Sch Med, Kerman, Iran.
EM najibi2008@yahoo.com; miladdaneshi@gmail.com; a_dorosty@yahoo.com
RI Daneshi-Maskooni, Milad/C-1139-2019
OI Daneshi-Maskooni, Milad/0000-0003-1373-1358
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NR 88
TC 12
Z9 12
U1 0
U2 3
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2458
J9 BMC PUBLIC HEALTH
JI BMC Public Health
PD JUL 5
PY 2019
VL 19
AR 885
DI 10.1186/s12889-019-7236-9
PG 8
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA IH5XB
UT WOS:000474565700001
PM 31277616
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Mäntyselkä, P
   Kautiainen, H
   Vanhala, M
AF Mantyselka, Pekka
   Kautiainen, Hannu
   Vanhala, Mauno
TI Prevalence of neck pain in subjects with metabolic syndrome - a
   cross-sectional population-based study
SO BMC MUSCULOSKELETAL DISORDERS
LA English
DT Article
ID CARDIOVASCULAR-DISEASE; MUSCULOSKELETAL PAIN; PHYSICAL-ACTIVITY;
   RISK-FACTORS; FOLLOW-UP; MORTALITY; STRESS; BACK; MANAGEMENT; SHOULDER
AB Background: Metabolic syndrome (MetS) is increasingly common. Obesity has been suggested to associate with neck pain but prevalence of neck pain in subjects with MetS has not been studied. Aim of this study was to analyse the association between MetS and neck pain.
   Methods: The study population consisted of 1294 middle-aged subjects in Pieksamaki, Finland. A total of 399 males and 500 females participated (69%). The mean age of both males and females was 46 years. Clinical and biochemical measurements were taken. The participants filled out a standard questionnaire. Psychological distress was assessed with the 12-item General Health Questionnaire (GHQ-12). Neck pain was defined as neck pain perceived daily. MetS was defined using National Cholesterol Education Program (NCEP) criteria. Statistical comparisons between the groups were performed using a bootstrap-type t-test or Chi-Square test. Risk ratios of having neck pain were calculated using generalised linear models with age, smoking, alcohol use, exercise and GHQ-12 score as covariates.
   Results: The prevalence of MetS was 33% in males and 29% in females. Neck pain was present in 11% (N = 42) of males and 19% (N = 93) of females (P < 0.001). The prevalence of neck pain was 7.9% (95% CI, 4.9% to 12%) among male subjects without MetS and 16% (95% CI, 10% to 23%) among those with MetS. The respective proportions among females were 16% (95% CI, 12% to 20%) and 25% (95% CI, 18% to 33%). The multivariate analysis showed an increased risk of neck pain in males with MetS (RR 2.1, 95% CI, 1.2 to 3.7, P = 0.010) and in females with MetS (RR 1.5, 95% CI, 1.0 to 2.1, P = 0.040).
   Conclusions: MetS was associated with neck pain. This association was stronger in males, but the prevalence of neck pain was higher in females. Prospective studies should explore the potential causal association between neck pain and MetS and the potential common background factors of neck pain and MetS.
C1 [Mantyselka, Pekka; Vanhala, Mauno] Univ Eastern Finland, Sch Med, Kuopio, Finland.
   [Mantyselka, Pekka] Kuopio Univ Hosp, Unit Primary Hlth Care, SF-70210 Kuopio, Finland.
   [Kautiainen, Hannu] ORION Fdn, Helsinki, Finland.
   [Vanhala, Mauno] Cent Hosp Middle Finland, Unit Family Practice, Jyvaskyla, Finland.
C3 University of Eastern Finland; University of Eastern Finland; University
   of Eastern Finland Hospital; Kuopio University Hospital; Central Finland
   Central Hospital
RP Mäntyselkä, P (corresponding author), Univ Eastern Finland, Sch Med, Kuopio, Finland.
EM pekka.mantyselka@uef.fi
FU Northern Savo and Central Finland Hospital Districts
FX This study has been supported by the Northern Savo and Central Finland
   Hospital Districts.
CR [Anonymous], JAMA
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NR 26
TC 30
Z9 34
U1 0
U2 5
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-2474
J9 BMC MUSCULOSKEL DIS
JI BMC Musculoskelet. Disord.
PD JUL 30
PY 2010
VL 11
AR 171
DI 10.1186/1471-2474-11-171
PG 6
WC Orthopedics; Rheumatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Rheumatology
GA 637RD
UT WOS:000280835500001
PM 20670458
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Hainer, V
   Hlavatá, K
   Gojová, M
   Kunesová, M
   Wagenknecht, M
   Kopsky, V
   Parizková, J
   Hill, M
   Nedvídková, J
AF Hainer, V.
   Hlavata, K.
   Gojova, M.
   Kunesova, M.
   Wagenknecht, M.
   Kopsky, V.
   Parizkova, J.
   Hill, M.
   Nedvidkova, J.
TI Hormonal and psychobehavioral predictors of weight loss in response to a
   short-term weight reduction program in obese women
SO PHYSIOLOGICAL RESEARCH
LA English
DT Article
DE obesity; weight loss predictors; hormones; eating inventory; beck
   depression inventory - anthropometric indexes
ID LOW-CALORIE DIET; LEPTIN LEVELS; PANCREATIC-POLYPEPTIDE; PLASMA LEPTIN;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; PROLACTIN-RELEASE; EXCESS
   REDUCTION; GROWTH-HORMONE; FAT OXIDATION
AB Among the factors influencing weight loss and maintenance, psychobehavioral, nutritional, metabolic, hormonal and hereditary predictors play an important role. Psychobehavioral factors influence adherence to lifestyle changes and thus weight loss maintenance. The outcome of short-term weight reduction treatment is mainly affected by changes in energy and nutrient intake and physical activity and thus the impact of hormones can possibly be obscured. In order to reveal hormonal determinants of weight loss, a 4-week in-patient comprehensive weight reduction program was introduced in which food intake and physical activity were under the strict control. Women (n = 67, BMI: 32.4 +/- 4.4 kg; age: 48.7 +/- 12.2 years) who exhibited stable weight on a 7 MJ/day diet during the first week of weight management were given a hypocaloric diet yielding daily energy deficit 2.5 MJ over the subsequent 3-week period. This treatment resulted in a mean weight loss of 3.80 +/- 1.64 kg. Correlation analysis revealed that baseline concentrations of several hormones were significantly associated either with a higher (free triiodothyronine, C-peptide, growth hormone, pancreatic polypeptide) or with a lower (insulin-like growth factor-I, cortisol, adiponectin, neuropeptide Y) reduction of anthropometric parameters in response to weight management. In a backward stepwise regression model age, initial BMI together with baseline levels of growth hormone, peptide YY, neuropetide Y and Creactive protein predicted 49.8% of the variability in weight loss. Psychobehavioral factors (items of the Eating Inventory, Beck Depression score) did not contribute to weight change induced by a well-controlled short-term weight reduction program.
C1 [Hainer, V.; Hlavata, K.; Kunesova, M.; Wagenknecht, M.; Kopsky, V.; Parizkova, J.; Hill, M.; Nedvidkova, J.] Res Inst Endocrinol, Narodni Trida 8, CR-11694 Prague 1, Czech Republic.
   [Gojova, M.] Obes Management Unit, Lipova Lazne, Czech Republic.
C3 Institute of Endocrinology - Prague
RP Hainer, V (corresponding author), Res Inst Endocrinol, Narodni Trida 8, CR-11694 Prague 1, Czech Republic.
EM vhainer@endo.cz
RI Hill, Martin/G-7699-2019
OI Hill, Martin/0000-0002-1705-0835
CR Albert SG, 2004, J CLIN ENDOCR METAB, V89, P695, DOI 10.1210/jc.2003-031264
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NR 56
TC 17
Z9 21
U1 1
U2 15
PU ACAD SCIENCES CZECH REPUBLIC, INST PHYSIOLOGY
PI PRAGUE 4
PA VIDENSKA 1083, PRAGUE 4 142 20, CZECH REPUBLIC
SN 0862-8408
EI 1802-9973
J9 PHYSIOL RES
JI Physiol. Res.
PY 2008
VL 57
SU 1
BP S17
EP S27
DI 10.33549/physiolres.931486
PG 11
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA 308PW
UT WOS:000256403500003
PM 18271695
OA gold
DA 2025-06-11
ER

PT J
AU Basu, L
   Grieco-St-Pierre, L
   Ching, MEA
   Stead, JDH
   Hanson, AA
   Palaniyandi, J
   van Zyl, E
   Hoyeck, MP
   Mckay, KS
   van Allen, KA
   Lee, HYJ
   Dai, XQ
   Bautista, A
   Fadzeyeva, E
   Mulvihill, EE
   Yauk, CL
   Mennigen, JA
   Macdonald, PE
   Bruin, JE
AF Basu, Lahari
   Grieco-St-Pierre, Lili
   Ching, Ma. Enrica Angela
   Stead, John D. H.
   Hanson, Antonio A.
   Palaniyandi, Jana
   van Zyl, Erin
   Hoyeck, Myriam P.
   Mckay, Kelsea S.
   van Allen, Kyle A.
   Lee, Hyojin
   Dai, Xiao-Qing
   Bautista, Austin
   Fadzeyeva, Evgenia
   Mulvihill, Erin E.
   Yauk, Carole L.
   Mennigen, Jan A.
   Macdonald, Patrick E.
   Bruin, Jennifer E.
TI Cisplatin Exposure Dysregulates Insulin Secretion in Male and Female
   Mice
SO DIABETES
LA English
DT Article
ID LONG-TERM SURVIVORS; METABOLIC SYNDROME; DIABETES-MELLITUS; CELL-DEATH;
   BCL-X(L); CANCER; MECHANISMS; BCL-2
AB Cancer survivors have an increased risk of developing type 2 diabetes compared with the general population. Patients treated with cisplatin, a common chemotherapeutic agent, are more likely to develop metabolic syndrome and type 2 diabetes than age- and sex-matched control patients. Surprisingly, the impact of cisplatin on pancreatic islets has not been reported. Our study aimed to determine whether mouse islet function is adversely affected by systemic (in vivo) or direct (in vitro) exposure to cisplatin. In vivo cisplatin exposure led to deficits in glucose-stimulated plasma insulin levels in both male and female mice, despite no differences in glucose tolerance. In vitro cisplatin exposure to mouse islets dysregulated insulin release and reduced oxygen consumption in a non-sex-specific manner. When shifting our focus to male mouse islets, cisplatin altered the expression of genes related to insulin production, oxidative stress, and the Bcl-2 family as early as 6 h postexposure. Genome-wide expression analysis confirmed the pronounced downregulation of genes within the insulin secretion pathway in cisplatin-exposed mouse islets. Data from three human organ donors confirmed that the detrimental effects of cisplatin on insulin secretion and gene expression are reproduced in human islets. Our findings indicate that cisplatin exposure causes significant defects in insulin secretion and may have lasting effects on islet health. Article Highlights center dot Cancer survivors who receive cisplatin chemotherapy have an increased risk of type 2 diabetes, but the underlying mechanisms remain unclear. center dot The aim of this study was to investigate whether cisplatin impacts beta-cell health and function, thereby contributing to increased type 2 diabetes risk in cancer survivors. center dot In vivo and in vitro cisplatin exposure dysregulated insulin secretion in male and female mice. In vitro cisplatin exposure reduced oxygen consumption, impaired beta-cell exocytotic capacity, and altered expression of genes within the insulin secretion pathway in mouse islets. center dot Understanding how chemotherapeutic drugs cause beta-cell injury is critical for designing targeted interventions to reduce the risk of cancer survivors developing type 2 diabetes after treatment.
C1 [Basu, Lahari; Grieco-St-Pierre, Lili; Ching, Ma. Enrica Angela; Hanson, Antonio A.; Palaniyandi, Jana; van Zyl, Erin; Hoyeck, Myriam P.; Mckay, Kelsea S.; van Allen, Kyle A.; Bruin, Jennifer E.] Carleton Univ, Dept Biol, Ottawa, ON, Canada.
   [Basu, Lahari; Grieco-St-Pierre, Lili; Ching, Ma. Enrica Angela; Hanson, Antonio A.; Palaniyandi, Jana; van Zyl, Erin; Hoyeck, Myriam P.; Mckay, Kelsea S.; van Allen, Kyle A.; Bruin, Jennifer E.] Carleton Univ, Inst Biochem, Ottawa, ON, Canada.
   [Stead, John D. H.] Carleton Univ, Dept Neurosci, Ottawa, ON, Canada.
   [Lee, Hyojin; Yauk, Carole L.; Mennigen, Jan A.] Univ Ottawa, Dept Biol, Ottawa, ON, Canada.
   [Dai, Xiao-Qing; Bautista, Austin; Macdonald, Patrick E.] Univ Alberta, Alberta Diabet Inst, Edmonton, AB, Canada.
   [Dai, Xiao-Qing; Bautista, Austin; Macdonald, Patrick E.] Univ Alberta, Dept Pharmacol, Edmonton, AB, Canada.
   [Fadzeyeva, Evgenia; Mulvihill, Erin E.] Univ Ottawa Heart Inst, Ottawa, ON, Canada.
   [Fadzeyeva, Evgenia; Mulvihill, Erin E.] Univ Ottawa, Fac Med, Dept Biochem Microbiol & Immunol, Ottawa, ON, Canada.
C3 Carleton University; Carleton University; Carleton University;
   University of Ottawa; University of Alberta; University of Alberta;
   University of Ottawa; University of Ottawa Heart Institute; University
   of Ottawa
RP Bruin, JE (corresponding author), Carleton Univ, Dept Biol, Ottawa, ON, Canada.; Bruin, JE (corresponding author), Carleton Univ, Inst Biochem, Ottawa, ON, Canada.
EM jenny.bruin@carleton.ca
RI Stead, John/X-8500-2018; MacDonald, Patrick/A-4154-2008
OI MacDonald, Patrick/0000-0002-5439-6288
FU Canadian Institutes of Health Research/Breakthrough T1D/Diabetes Canada
FX Acknowledgments. Human islets for research were provided by the Alberta
   Diabetes Institute IsletCore at the University of Alberta in Edmonton
   (https://www.bcell.org/adi-isletcore.html) with the assistance of the
   Human Organ Procurement and Exchange (HOPE) program, Trillium Gift of
   Life Network (TGLN), and other Canadian organ procurement organizations.
   The authors are extremely grateful to Dr. Bruce McKay (Carleton
   University) for mentorship and guidance for this project. The authors
   also sincerely thank Andrea Smith, Kayleigh Rick, and Emilia
   Poleo-Giordani, all from Carleton University, for their early
   contributions to this project.
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NR 48
TC 1
Z9 1
U1 1
U2 1
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0012-1797
EI 1939-327X
J9 DIABETES
JI Diabetes
PD APR
PY 2025
VL 74
IS 4
BP 528
EP 543
DI 10.2337/db24-0419
PG 16
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 0KR0Y
UT WOS:001449646900015
PM 39808439
DA 2025-06-11
ER

PT J
AU Gao, XY
   Zhao, HJ
   Shi, QL
   Zou, T
   Zhu, YD
AF Gao, Xueyan
   Zhao, Huijuan
   Shi, Qingling
   Zou, Ting
   Zhu, Yidan
TI Exploring the causal pathway from gut microbiota to polycystic ovary
   syndrome: A network Mendelian randomization study
SO MEDICINE
LA English
DT Article
DE gut microbiota; inverse-variance weighted; Mendelian randomization
   analysis; Phenowide-MR; polycystic ovary syndrome
ID CHAIN FATTY-ACIDS; DIAGNOSTIC-CRITERIA; GENETIC-VARIANTS; SYNDROME PCOS;
   DEFINITION; MEDIATION; OBESITY; RISK; AXIS
AB Polycystic ovary syndrome (PCOS) is a complicated endocrine and metabolic syndrome with unclear pathogenesis. The gut microbiota sheds light on the etiology and pathophysiology of PCOS. We used Mendelian randomization (MR) studies to systematically evaluate the pathological mechanism gut microbiota causally associated with PCOS risk. A network MR analysis was performed to estimate the causal effects of gut microbiota and risk factors on PCOS, as well as the mediation effect of risk factors linking gut microbiota to PCOS. The investigation of side effects for the important gut microbiota was subsequently broadened to include phenotypes by performing Phenowide-MR analysis for a range of diseases. Genus Sellimonas id.14369 were causally associated with reduced PCOS risk (odds ratio [OR] = 0.69, 95% confidence interval [CI]: 0.58-0.84, P = 1.22 x 10(-4)) after multiple testing correction. And Sellimonas retained consistent causal effect estimates after a series of sensitivity analyses. In addition, we observed an indirect effect of Sellimonas on PCOS through body mass index (BMI) using network MR (b = -0.05, 95% CI: -0.09 to -0.01), with a mediated proportion of 12.82% of the total effect. Further, Phenowide-MR analyses showed that the protective effects of Sellimonas on type 2 diabetes and depression (for type 2 diabetes: OR = 0.95, 95% CI: 0.90-0.99, P = .0366; for depression: OR = 0.99, 95% CI: 0.98-1.00, P = .0210). We summarized that the causal path between gut microbiota and type 2 diabetes are also jointly mediated by BMI. Sellimonas may be a protective factor of PCOS, which can affect the occurrence of PCOS through BMI, supporting future studies on the importance of addressing obesity and metabolic issues in preventing and managing PCOS.
C1 [Gao, Xueyan; Zhao, Huijuan; Shi, Qingling; Zou, Ting; Zhu, Yidan] Nanjing Med Univ, Geriatr Hosp, Dept Gen Med, Nanjing 210023, Peoples R China.
C3 Nanjing Medical University
RP Shi, QL (corresponding author), Nanjing Med Univ, Geriatr Hosp, Dept Gen Med, Nanjing 210023, Peoples R China.
EM shellzhjdhell@sina.com; 13951942507@163.com; 2285995536@qq.com;
   yue040605@sina.com
RI Gao, Xueyan/W-6981-2018
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NR 53
TC 0
Z9 0
U1 3
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD OCT 18
PY 2024
VL 103
IS 42
AR e40115
DI 10.1097/MD.0000000000040115
PG 9
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA M6F8B
UT WOS:001358481200068
PM 39432652
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Lyu, C
   Tsinovoi, CL
   Xun, PC
   Song, YQ
   Pu, YJ
   Rosanoff, A
   Iribarren, C
   Schreiner, PJ
   Shikany, JM
   Jacobs, DR
   Kahe, K
AF Lyu, Chen
   Tsinovoi, Cari L.
   Xun, Pengcheng
   Song, Yiqing
   Pu, Yongjia
   Rosanoff, Andrea
   Iribarren, Carlos
   Schreiner, Pamela J.
   Shikany, James M.
   Jacobs, David R.
   Kahe, Ka
TI Magnesium intake was inversely associated with hostility among American
   young adults
SO NUTRITION RESEARCH
LA English
DT Article
DE Hostility; Magnesium intake; Prospective study; CARDIA; Generalized
   estimating equations
ID METABOLIC SYNDROME; AGGRESSIVE-BEHAVIOR; FATTY-ACIDS; DEPRESSION; RISK;
   CHOLESTEROL; DISEASE; INFLAMMATION; SEROTONIN; SYMPTOMS
AB Hostility is a complex personality trait associated with many cardiovascular risk factor phenotypes. Although magnesium intake has been related to mood and cardio-metabolic disease, its relation with hostility remains unclear. We hypothesize that high total magnesium intake is associated with lower levels of hostility because of its putative antidepressant mechanisms. To test the hypothesis, we prospectively analyzed data in 4,716 young adults aged 18-30 years at baseline (1985-1986) from four U.S. cities over five years of follow-up using data from the Coronary Artery Risk Development in Young Adults (CARDIA) study. Magnesium intake was estimated from a dietary history questionnaire plus supplements at baseline. Levels of hostility were assessed using the Cook-Medley scale at baseline and year 5 (1990-1991). Generalized estimating equations were applied to estimate the association of magnesium intake with hostility as repeated measures at the two time-points (baseline and year 5). General linear model was used to determine the association between magnesium intake and change in hostility over 5 years. After adjustment for socio-demographic and major lifestyle factors, a significant inverse association was observed between magnesium intake and hostility level over 5 years of follow-up. Beta coefficients (95% CI) across higher quintiles of magnesium intake were 0 (reference),-1.28 (-1.92,-0.65),-1.45 (-2.09,-0.81),-1.41 (-2.08,-0.75) and-2.16 (-2.85,-1.47), respectively (Plinear-trend < .01). The inverse association was inde-pendent of socio-demographic and major lifestyle factors, supplement use, and depression status at year 5. This prospective study provides evidence that in young adults, high magne-sium intake was inversely associated with hostility level independent of socio-demographic and major lifestyle factors.
   (c) 2021 Elsevier Inc. All rights reserved.
C1 [Lyu, Chen; Tsinovoi, Cari L.; Xun, Pengcheng; Pu, Yongjia] Indiana Univ, Dept Epidemiol & Biostat, Bloomington, IA USA.
   [Song, Yiqing] Indiana Univ, Richard M Fairbanks Sch Publ Hlth, Dept Epidemiol, Indianapolis, IA USA.
   [Rosanoff, Andrea] Ctr Magnesium Educ & Res, Pahoa, HI USA.
   [Iribarren, Carlos] Kaiser Permanente Div Res, Oakland, CA USA.
   [Schreiner, Pamela J.] Univ Minnesota, Div Epidemiol & Community Hlth, Minneapolis, MN USA.
   [Shikany, James M.] Univ Alabama Birmingham, Div Prevent Med, Birmingham, AL USA.
   [Jacobs, David R.] Univ Minnesota, Div Epidemiol, Minneapolis, MN 55455 USA.
   [Kahe, Ka] Columbia Univ, Dept Obstet & Gynecol, Irving Med Ctr, 622 West 168th St, New York, NY 10032 USA.
C3 Indiana University System; Indiana University Bloomington; Indiana
   University System; Indiana University Indianapolis; Kaiser Permanente;
   University of Minnesota System; University of Minnesota Twin Cities;
   University of Alabama System; University of Alabama Birmingham;
   University of Minnesota System; University of Minnesota Twin Cities;
   Columbia University; NewYork-Presbyterian Hospital
RP Kahe, K (corresponding author), Columbia Univ, Dept Obstet & Gynecol, Irving Med Ctr, 622 West 168th St, New York, NY 10032 USA.; Kahe, K (corresponding author), Columbia Univ, Dept Epidemiol, Irving Med Ctr, 622 West 168th St, New York, NY 10032 USA.
EM kk3399@columbia.edu
RI Rosanoff, Andrea/L-6869-2019; Jacobs, David/G-5405-2011; song,
   yiqing/KHZ-9887-2024; pengcheng, xun/D-3411-2013; Lyu,
   Chen/GSD-2121-2022
OI Rosanoff, Andrea/0000-0002-7811-9517; Xun,
   Pengcheng/0000-0002-6245-4505; Jacobs, David/0000-0002-7232-0543;
   Schreiner, Pamela/0000-0002-9920-6257
FU NIH [R01HL081572, R01ES021735, R01DK116603, RF1AG56111]; National Heart,
   Lung, and Blood Institute (NHLBI) [HHSN268201300025C, HHSN268201300026C,
   HHSN268201300027C, HSN268201300028C, HHSN268201300029C,
   HHSN268200900041C]; Intramural Research Program of the National
   Institute on Aging (NIA); NIA [AG0005]; NHLBI [AG0005]
FX The authors thank the other investigators and the staff of the CARDIA
   Study for valuable contributions. This study was partially supported by
   grants from the NIH (R01HL081572, R01ES021735, R01DK116603, and
   RF1AG56111) . The CAR-DIA Study is supported by contracts
   HHSN268201300025C, HHSN268201300026C, HHSN268201300027C,
   HSN268201300028C, HHSN268201300029C, and HHSN268200900041C from the
   National Heart, Lung, and Blood Institute (NHLBI) , the Intramural
   Research Program of the National Institute on Aging (NIA) and an
   intraagency agreement between NIA and NHLBI (AG0005) . The authors
   confirm that none of the authors had a conflict of interest.
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NR 56
TC 3
Z9 3
U1 0
U2 3
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0271-5317
EI 1879-0739
J9 NUTR RES
JI Nutr. Res.
PD MAY
PY 2021
VL 89
BP 35
EP 44
DI 10.1016/j.nutres.2021.01.001
EA APR 2021
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nutrition & Dietetics
GA RU1RE
UT WOS:000644927300004
PM 33894659
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Kuo, CF
   Grainge, MJ
   Mallen, C
   Zhang, WY
   Doherty, M
AF Kuo, Chang-Fu
   Grainge, Matthew J.
   Mallen, Christian
   Zhang, Weiya
   Doherty, Michael
TI Comorbidities in patients with gout prior to and following diagnosis:
   case-control study
SO ANNALS OF THE RHEUMATIC DISEASES
LA English
DT Article
ID URIC-ACID LEVELS; EVIDENCE BASED RECOMMENDATIONS; MYOCARDIAL-INFARCTION;
   METABOLIC SYNDROME; HEALTH-PROFESSIONALS; INDEPENDENT IMPACT;
   NATIONAL-HEALTH; RISK-FACTOR; TASK-FORCE; ALL-CAUSE
AB Objectives To determine the burden of comorbidities in patients with gout at diagnosis and the risk of developing new comorbidities post diagnosis.
   Methods There were 39 111 patients with incident gout and 39 111 matched controls identified from the UK Clinical Practice Research Data-link. The risk of comorbidity before (ORs) and after the diagnosis of gout (HRs) were estimated, adjusted for age, sex, diagnosis year, body mass index, smoking and alcohol consumption.
   Results Gout was associated with adjusted ORs (95% CIs) of 1.39 (1.34 to 1.45), 1.89 (1.76 to 2.03) and 2.51 (2.19 to 2.86) for the Charlson index of 1-2, 3-4 and >= 5, respectively. Cardiovascular and genitourinary diseases, in addition to hyperlipidaemia, hypothyroidism, anaemia, psoriasis, chronic pulmonary diseases, osteoarthritis and depression, were associated with a higher risk for gout. Gout was also associated with an adjusted HR (95% CI) of 1.41 (1.34 to 1.48) for having a Charlson index >= 1. Median time to first comorbidity was 43 months in cases and 111 months in controls. Risks for incident comorbidity were higher in cardiovascular, genitourinary, metabolic/endocrine and musculoskeletal diseases, in addition to liver diseases, hemiplegia, depression, anaemia and psoriasis in patients with gout. After additionally adjusting for all comorbidities at diagnosis, gout was associated with a HR (95% CI) for all-cause mortality of 1.13 (1.08 to 1.18; p<0.001).
   Conclusions The majority of patients with gout have worse pre-existing health status at diagnosis and the risk of incident comorbidity continues to rise following diagnosis. The range of associated comorbidities is broader than previously recognised and merits further evaluation.
C1 [Kuo, Chang-Fu; Zhang, Weiya; Doherty, Michael] Univ Nottingham, Sch Med, Div Rheumatol Orthopaed & Dermatol, Nottingham, England.
   [Kuo, Chang-Fu] Chang Gung Mem Hosp, Div Rheumatol Allergy & Immunol, Taoyuan, Taiwan.
   [Grainge, Matthew J.] Univ Nottingham, Sch Med, Div Epidemiol & Publ Hlth, Nottingham, England.
   [Mallen, Christian] Keele Univ, Arthritis Res UK Primary Care Ctr, Keele ST5 5BG, Staffs, England.
C3 University of Nottingham; Chang Gung Memorial Hospital; University of
   Nottingham; Keele University
RP Zhang, WY (corresponding author), City Hosp, Acad Rheumatol, Clin Sci Bldg, Nottingham NG5 1PB, England.
EM weiya.zhang@nottingham.ac.uk
RI Kuo, Chang-Fu/Q-1714-2016; Zhang, Weiya/X-9481-2019
OI Grainge, Matthew/0000-0001-7181-4042; Zhang, Weiya/0000-0003-1142-1460;
   Doherty, Michael/0000-0002-5763-8326
FU National Science Council of Taiwan [103-2314-B-182A-070-MY2]; Chang Gung
   Memorial Hospital [CMRPG3A0624]; University of Nottingham
FX This work was funded by the National Science Council of Taiwan (project
   103-2314-B-182A-070-MY2) and Chang Gung Memorial Hospital (project
   CMRPG3A0624) and supported by the University of Nottingham for
   methodological assistance. The sponsors of the study had no role in
   design and conduct of the study; collection, management, analysis and
   interpretation of the data; and preparation, review or approval of the
   manuscript.
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NR 73
TC 176
Z9 185
U1 4
U2 30
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 0003-4967
EI 1468-2060
J9 ANN RHEUM DIS
JI Ann. Rheum. Dis.
PD JAN
PY 2016
VL 75
IS 1
BP 210
EP 217
DI 10.1136/annrheumdis-2014-206410
PG 8
WC Rheumatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Rheumatology
GA CY4TW
UT WOS:000366402400028
PM 25398375
OA Green Accepted, Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Vignini, A
   Sabbatinelli, J
   Clemente, N
   Delli Carpini, G
   Tassetti, M
   Zagaglia, G
   Ciavattini, A
AF Vignini, Arianna
   Sabbatinelli, Jacopo
   Clemente, Nicolo
   Delli Carpini, Giovanni
   Tassetti, Marta
   Zagaglia, Giulia
   Ciavattini, Andrea
TI Preperitoneal Fat Thicknesses, Lipid Profile, and Oxidative Status in
   Women With Uterine Fibroids
SO REPRODUCTIVE SCIENCES
LA English
DT Article
DE leiomyoma; preperitoneal fat thickness; oxidative stress; lipid profile;
   visceral adiposity
ID LOW-DENSITY-LIPOPROTEIN; SMOOTH-MUSCLE-CELLS; METABOLIC SYNDROME;
   COLORECTAL-CANCER; POTENTIAL ROLE; VISCERAL FAT; SERUM-LEVELS; RISK;
   LEIOMYOMA; OBESITY
AB Purpose: There is growing evidence supporting a possible role for metabolic syndrome and its determinants, such as dyslipidemia, in uterine fibroid (UF) pathogenesis. The present study aims to investigate the association between UFs and visceral and subcutaneous fat thickness (SFT), lipid profile, and oxidative and antioxidative status.
   Methods: In this cross-sectional study, 35 patients diagnosed with UFs and 15 women without UFs were enrolled. Clinical history and anthropometric parameters were collected for every woman. Characteristics of UFs, preperitoneal fat thickness (PFT), and SFT were assessed ultrasonically. Lipid profile, glucose, thiobarbituric acid reactive substances (TBARs), and superoxide dismutase (SOD) activity were evaluated on plasma from participants.
   Results: Women with UFs showed a significantly increased PFT (11.63 3.39 vs 7.01 +/- 3.10 mm; P < .001), lower levels of high-density lipoprotein cholesterol (HDL-C; 45.4 +/- 8.3 vs 57.2 +/- 13.4 mg/dL; P = .017), higher levels of low-density lipoprotein cholesterol (LDL-C; 92.3 +/- 21.5 vs 72.0 +/- 14.6 mg/dL; P = .007), and oxidized LDL (65.2 +/- 20.7 vs 43.0 +/- 11.3 U/L; P = .002). In patients, TBARs concentration was significantly higher (9.41 +/- 6.49 vs 2.92 +/- 1.65 nmol malondialdehyde/100 g prot; P < .001), whereas SOD activity was lower (1.09 +/- 0.19 vs 1.37 +/- 0.41 U/L; P = .005). Preperitoneal fat thickness was positively associated with body mass index, oxidized LDL, and TBARs. At multivariate analysis, PFT and HDL-C maintained a significant correlation with the diagnosis of UFs.
   Conclusion: Chronic inflammation triggered and sustained by visceral fat could play a determinant role in cell differentiation and proliferation processes, necessary for the development of UFs. Alterations in cholesterol fractions may be explained as a consequence of the increased visceral fat deposits and can reflect an increased risk of subclinical atherosclerosis in patients with UF.
C1 [Vignini, Arianna; Sabbatinelli, Jacopo] Univ Politecn Marche, Sect Biochem Biol & Phys, Dept Clin Sci, Ancona, Italy.
   [Clemente, Nicolo; Delli Carpini, Giovanni; Tassetti, Marta; Zagaglia, Giulia; Ciavattini, Andrea] Univ Politecn Marche, Gynecol Sect, Womans Hlth Sci Dept, Ancona, Italy.
C3 Marche Polytechnic University; Marche Polytechnic University
RP Sabbatinelli, J (corresponding author), Univ Politecn Marche, Biochem Sect, Dept Clin Sci, Via Tronto 10-A, I-60126 Ancona, Italy.
EM j.sabbatinelli@pm.univpm.it
RI Delli Carpini, Giovanni/AAC-2123-2019; Ciavattini, Andrea/AAC-1862-2019;
   Sabbatinelli, Jacopo/U-1851-2018; Clemente, Nicolo/ABF-7915-2020
OI Sabbatinelli, Jacopo/0000-0001-9947-6778; Ciavattini,
   Andrea/0000-0002-8037-4947; Delli Carpini, Giovanni/0000-0003-2849-4690;
   Clemente, Nicolo/0000-0003-2748-3041
FU RSA
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: The
   present work was supported by RSA grant 2015 to Prof. Andrea Ciavattini,
   Universita Politecnica delle Marche.
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NR 40
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Z9 17
U1 0
U2 5
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1933-7191
EI 1933-7205
J9 REPROD SCI
JI Reprod. Sci.
PD OCT
PY 2017
VL 24
IS 10
BP 1419
EP 1425
DI 10.1177/1933719116689598
PG 7
WC Obstetrics & Gynecology; Reproductive Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology; Reproductive Biology
GA FH3WD
UT WOS:000411079900008
PM 28122481
DA 2025-06-11
ER

PT J
AU Ross, D
   Siegel, D
AF Ross, David
   Siegel, David
TI Functions of NQO1 in Cellular Protection and CoQ10 Metabolism
   and its Potential Role as a Redox Sensitive Molecular Switch
SO FRONTIERS IN PHYSIOLOGY
LA English
DT Review
DE quinone reductases; quinones; coenzyme Q; vitamin E; superoxide;
   polymorphism; single nucleotide
ID NAD(P)HQUINONE OXIDOREDUCTASE 1; UBIQUITIN-INDEPENDENT DEGRADATION;
   SPONTANEOUSLY HYPERTENSIVE-RATS; DT-DIAPHORASE; NAD(P)H-QUINONE
   OXIDOREDUCTASE-1; PROTEASOMAL DEGRADATION; QUINONE OXIDOREDUCTASE;
   CRYSTAL-STRUCTURE; BETA-LAPACHONE; MITOMYCIN-C
AB NQO1 is one of the two major quinone reductases in mammalian systems. It is highly inducible and plays multiple roles in cellular adaptation to stress. A prevalent polymorphic form of NQO1 results in an absence of NQO1 protein and activity so it is important to elucidate the specific cellular functions of NQO1. Established roles of NQO1 include its ability to prevent certain quinones from one electron redox cycling but its role in quinone detoxification is dependent on the redox stability of the hydroquinone generated by two-electron reduction. Other documented roles of NQO1 include its ability to function as a component of the plasma membrane redox system generating antioxidant forms of ubiquinone and vitamin E and at high levels, as a direct superoxide reductase. Emerging roles of NQO1 include its function as an efficient intracellular generator of NAD+ for enzymes including PARP and sirtuins which has gained particular attention with respect to metabolic syndrome. NQO1 interacts with a growing list of proteins, including intrinsically disordered proteins, protecting them from 20S proteasomal degradation. The interactions of NQO1 also extend to mRNA. Recent identification of NQO1 as a mRNA binding protein have been investigated in more detail using SERPIN1A1 (which encodes the serine protease inhibitor a-1-antitrypsin) as a target mRNA and indicate a role of NQO1 in control of translation of a-1-antitrypsin, an important modulator of COPD and obesity related metabolic syndrome. NQO1 undergoes structural changes and alterations in its ability to bind other proteins as a result of the cellular reduced/oxidized pyridine nucleotide ratio. This suggests NQO1 may act as a cellular redox switch potentially altering its interactions with other proteins and mRNA as a result of the prevailing redox environment.
C1 [Ross, David; Siegel, David] Univ Colorado, Skaggs Sch Pharm, Dept Pharmaceut Sci, Anschutz Med Campus, Aurora, CO 80045 USA.
C3 University of Colorado System; University of Colorado Anschutz Medical
   Campus
RP Ross, D (corresponding author), Univ Colorado, Skaggs Sch Pharm, Dept Pharmaceut Sci, Anschutz Med Campus, Aurora, CO 80045 USA.
EM david.ross@ucdenver.edu
OI Ross, David/0000-0002-8307-5942
FU NIH [CA51210, DK109964]
FX DR and DS were supported in part by NIH grants CA51210 and DK109964.
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NR 97
TC 236
Z9 262
U1 4
U2 32
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-042X
J9 FRONT PHYSIOL
JI Front. Physiol.
PD AUG 24
PY 2017
VL 8
AR 595
DI 10.3389/fphys.2017.00595
PG 10
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA FE5HG
UT WOS:000408242000001
PM 28883796
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Jaffiol, C
   Thomas, F
   Bean, K
   Jégo, B
   Danchin, N
AF Jaffiol, C.
   Thomas, F.
   Bean, K.
   Jego, B.
   Danchin, N.
TI Impact of socioeconomic status on diabetes and cardiovascular risk
   factors: Results of a large French survey
SO DIABETES & METABOLISM
LA English
DT Article
DE Diabetes; Deprivation; Epidemiology; Risk factors; Cardiovascular
   disease; Depression; Score EPICES
ID HEALTH BEHAVIORS; PREVALENCE; COMPLICATIONS; ASSOCIATION; DEPRESSION;
   POSITION; DEPRIVATION; MELLITUS; COUNTRY; DISEASE
AB Aim. This study examined the association between deprivation and diabetes in a large French population, and evaluated the impact of deprivation on diabetes after taking in account a number of confounding factors.
   Methods. A total of 32,435 men and 16,378 women, aged 35 to 80 years, who had a health checkup at the "Centre d'Investigations Preventives et Cliniques" (IPC Centre: a preventive medical center in Paris, France), between January 2003 and December 2006, were evaluated. Socioeconomic deprivation was assessed using the EPICES score. The most deprived subjects were those in the fifth quintile of score distribution.
   Results. Several cardiovascular risk markers increased significantly in deprived subjects. In both genders, deprivation was associated with deleterous health status and lifestyle habits. In women, BMI, central obesity and the metabolic syndrome were associated with deprivation. The prevalence of diabetes increased with deprivation level. Compared with the first quintile of EPICES score distribution, the prevalence of diabetes was three to eight times higher in the fifth quintile. After taking into account age, and biological, clinical and lifestyle parameters, the risk of diabetes onset (odds ratio) among deprived vs. non-deprived subjects was 2.54(95% CI: 1.99-3.24) in men and 2.2(95% CI: 1.44-3.35) in women.
   Conclusion. - In the general French population, deprivation was associated with deleterious health status and lifestyle. Risk of diabetes increased linearly with deprivation level and, after taking into account various confounding factors, the risk of diabetes remained significantly higher among deprived subjects. Other factors such as nutrition should now be examined to explain the excess risk of diabetes among the most deprived people. (C) 2012 Elsevier Masson SAS. All rights reserved.
C1 [Jaffiol, C.] Univ Paris 05, Paris, France.
   [Thomas, F.; Bean, K.; Jego, B.; Danchin, N.] Ctr Invest Prevent & Clin IPC, F-75116 Paris, France.
   [Danchin, N.] Hop Europeen Georges Pompidou, Paris, France.
C3 Universite Paris Cite; Assistance Publique Hopitaux Paris (APHP);
   Universite Paris Cite; Hopital Universitaire Europeen Georges-Pompidou -
   APHP
RP Thomas, F (corresponding author), Ctr Invest Prevent & Clin IPC, 6 Rue La Perouse, F-75116 Paris, France.
EM thomas@ipc.asso.fr
RI Danchin, Nicolas/AAN-8291-2020
FU CPAM-P; Primary Health Insurance Fund of Paris
FX We thank the Caisse Nationale d'Assurance Maladie des Travailleurs
   Salaries (CNAMTS, France), the Caisse Primaire d'Assurance Maladie de
   Paris (CPAM-P; Primary Health Insurance Fund of Paris) and the members
   of the French Academy of Medicine for helping make this study possible.
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NR 34
TC 46
Z9 47
U1 0
U2 7
PU MASSON EDITEUR
PI MOULINEAUX CEDEX 9
PA 21 STREET CAMILLE DESMOULINS, ISSY, 92789 MOULINEAUX CEDEX 9, FRANCE
SN 1262-3636
EI 1878-1780
J9 DIABETES METAB
JI Diabetes Metab.
PD FEB
PY 2013
VL 39
IS 1
BP 56
EP 62
DI 10.1016/j.diabet.2012.09.002
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism
GA 119JF
UT WOS:000317092900009
PM 23142159
DA 2025-06-11
ER

PT J
AU Reimets, R
   Raud, S
   Loomets, M
   Visnapuu, T
   Volke, V
   Reimets, A
   Plaas, M
   Vasar, E
AF Reimets, Riin
   Raud, Sirli
   Loomets, Maarja
   Visnapuu, Tanel
   Volke, Vallo
   Reimets, Ain
   Plaas, Mario
   Vasar, Eero
TI Variability in the effect of antidepressants upon Wfs1-deficient mice is
   dependent on the drugs' mechanism of actions
SO BEHAVIOURAL BRAIN RESEARCH
LA English
DT Article
DE Wfs1-deficient mice; Depression; Diabetes; Antidepressants; Tail
   suspension test; Glucose tolerance test
ID TAIL-SUSPENSION TEST; DIABETES-MELLITUS; METABOLIC SYNDROME;
   INSULIN-SECRETION; NUCLEUS-ACCUMBENS; MAJOR DEPRESSION; OPTIC ATROPHY;
   WFS1 PROTEIN; SEROTONIN; KETAMINE
AB There is significant comorbidity between mood disorders and diabetes. Wolfram syndrome-related to deficient WFS1 gene function-causes diabetes and mood disorders in humans. Mice lacking the Wfsl gene display impaired emotional behaviour and glucose metabolism. Various antidepressant drugs are used for alleviating the symptoms of mood disorders. For this study the tail suspension test and locomotor activity test were used to compare the effects of different antidepressants upon homozygous Wfsl deficient, heterozygous Wfs1-deficient and wild-type mice. Mouse glucose metabolism was concurrently studied using the glucose tolerance test.
   We showed that ketamine(10 mg/kg),NMDA antagonist, escitalopram(2.5-10 mg/kg), selective serotonin reuptake inhibitor(SSRI), and amitriptyline(10 mg/kg), noradrenaline and serotonin reuptake inhibitor, elicited a stronger antidepressant-like effect in homozygous Wfs1-deficient mice compared to wild-type mice. The effect of noradrenaline and serotonin reuptake inhibitor desipramine(10 and 20 mg/kg) did not differ between genotypes. The dopamine and noradrenaline reuptake inhibitor bupropion(5-20 mg/kg) had no significant antidepressant-like effect upon any genotype.
   Amitriptyline and desipramine potentiated a glucose elevation, escitalopram and bupropion did not affect glucose concentrations, and ketamine improved impaired glucose metabolism in homozygous Wfs1-deficient mice. Therefore, the results of this study suggest that SSRIs are the drugs of choice for the treatment of depressive symptoms in diabetic patients. The efficacy of ketamine for these patients remains to be established. Nonetheless, employing the mechanism of action of ketamine that affected glucose metabolism positively, could be an approach for development of improved antidepressants. Wfs1-deficient mice are likely the good animal model to develop new antidepressants more suitable for depressed patients with diabetes. (C) 2016 Elsevier B.V. All rights reserved.
C1 [Reimets, Riin; Raud, Sirli; Loomets, Maarja; Visnapuu, Tanel; Volke, Vallo; Reimets, Ain; Plaas, Mario; Vasar, Eero] Univ Tartu, Inst Biomed & Translat Med, Dept Physiol, 19 Ravila St, EE-50411 Tartu, Estonia.
   [Volke, Vallo] Tartu Univ Hosp, 8 L Puusepa St, Tartu, Estonia.
C3 University of Tartu
RP Reimets, R (corresponding author), Univ Tartu, Inst Biomed & Translat Med, Dept Physiol, 19 Ravila St, EE-50411 Tartu, Estonia.
EM riin.reimets@ut.ee
RI Plaas, Mario/DHC-3451-2022; Visnapuu, Tanel/AAJ-5503-2020; Volke,
   Vallo/AAL-9552-2020; Toots, Maarja/AAJ-9806-2020
OI Vasar, Eero/0000-0001-5226-345X; Toots, Maarja/0000-0002-8465-4866;
   Volke, Vallo/0000-0002-1753-3108; Plaas, Mario/0000-0002-1841-9059
FU European Union through the European Regional Development Fund
   [2014-2020.4.01.15-0012]; Estonian Research Council [9329, IUT 20-41]
FX This study was supported by the European Union through the European
   Regional Development Fund (Project No. 2014-2020.4.01.15-0012) and
   grants from the Estonian Research Council (9329, IUT 20-41).
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NR 66
TC 6
Z9 7
U1 0
U2 30
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0166-4328
EI 1872-7549
J9 BEHAV BRAIN RES
JI Behav. Brain Res.
PD JUL 15
PY 2016
VL 308
BP 53
EP 63
DI 10.1016/j.bbr.2016.04.011
PG 11
WC Behavioral Sciences; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Behavioral Sciences; Neurosciences & Neurology
GA DO5OT
UT WOS:000377833200007
PM 27080063
DA 2025-06-11
ER

PT J
AU Kim, KY
   Yun, JM
AF Kim, Kyoung Yun
   Yun, Jung-Mi
TI Association between diets and mild cognitive impairment in adults aged
   50 years or older
SO NUTRITION RESEARCH AND PRACTICE
LA English
DT Article
DE Cognitive dysfunction; diet; adult; surveys
ID MEDITERRANEAN DIET; METABOLIC SYNDROME; ALZHEIMER-DISEASE; LIFE-STYLE;
   PATTERN; DEPRESSION; VEGETABLES; DECLINE; RISK; PREDICTORS
AB BACKGROUND/OBJECTIVE: As aging progresses, the number of patients with cognitive impairment also increases. Cognitive function is not generally correlated with diet, and there is debate over that association. Thus, the present study aimed to investigate the association between dietary intake and cognitive function among adults aged 50 years or older.
   SUBJECTS/METHODS: Between July 2017 and March 2018, 324 adults aged over 50 years from Gwangju Sun-Han hospital participated in a dietary survey. The frequency of food intake and related information were collected using a semi-quantitative food frequency questionnaire (SQ-FFQ) and determining the mini-mental state examination (MMSE) level for 276 participants. The association between dietary intake and cognitive function was assessed by performing logistic regression analysis.
   RESULTS: Depending on the MMSE score, the participants' age, education level, inhabitation status, medications, alcohol consumption, sleep duration, physical activity, and short geriatric depression scale score were significantly different (P < 0.05). Moreover, those participant characteristics were associated with either decreased or increased odds ratios (OR) for the risk of mild cognitive impairment (MCI). Based on analysis of the participants' intake of 112 detailed food items, which were categorized into 20 food types, intakes of cooked white rice (< 2 times/day compared with 3 times/day) (P < 0.05), properly cooked rice with other grains and legumes (P < 0.001), fruits (P < 0.05), milk (low fat and normal) (P = 0.044), liquid-type yogurt (P = 0.019), and curd-type yogurt (P = 0.015) were found to significantly decrease the OR for the risk of MCI.
   CONCLUSIONS: Associations were significant between the risk of MCI and the intake of certain food types. Specifically, a moderate intake of cooked white rice and an adequate intake of whole grains, fruits, milk, and dairy products were associated with reduced risks of MCI among adults aged over 50 years.
C1 [Kim, Kyoung Yun] Sun Han Hosp, Dept Clin Nutr, Gwangju 61917, South Korea.
   [Kim, Kyoung Yun; Yun, Jung-Mi] Chonnam Natl Univ, Dept Food & Nutr, 77 Yongbong Ro, Gwangju 61186, South Korea.
C3 Chonnam National University
RP Yun, JM (corresponding author), Chonnam Natl Univ, Dept Food & Nutr, 77 Yongbong Ro, Gwangju 61186, South Korea.
EM sosung75@jnu.ac.kr
OI Kim, Kyoung Yun/0000-0001-8135-5273; Yun, Jung-Mi/0000-0001-6044-0647
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NR 45
TC 13
Z9 14
U1 4
U2 14
PU KOREAN NUTRITION SOC
PI SEOUL
PA 804 KST CTR, 635-4 YEOGSAM-SONG KANGNAM-KU, SEOUL, 135-703, SOUTH KOREA
SN 1976-1457
EI 2005-6168
J9 NUTR RES PRACT
JI Nutr. Res. Pract.
PD OCT
PY 2018
VL 12
IS 5
BP 415
EP 425
DI 10.4162/nrp.2018.12.5.415
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA HN5AH
UT WOS:000460194300007
PM 30323909
OA Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Gewirtz, H
AF Gewirtz, Henry
TI PET measurement of adenosine stimulated absolute myocardial blood flow
   for physiological assessment of the coronary circulation
SO JOURNAL OF NUCLEAR CARDIOLOGY
LA English
DT Review
DE PET; absolute myocardial blood flow; ischemic heart disease; adenosine
ID POSITRON-EMISSION-TOMOGRAPHY; ISCHEMIC-HEART-DISEASE; CARDIAC
   SYNDROME-X; ARTERY-DISEASE; MICROVASCULAR DYSFUNCTION; HIBERNATING
   MYOCARDIUM; MULTIVESSEL EVALUATION; PRESSURE MEASUREMENTS; FUNCTIONAL
   SEVERITY; STENOSIS SEVERITY
AB Considerable awareness has been raised of late of the need to reduce radiation exposure and control costs of x-ray and radionuclide imaging procedures. PET/CT cameras are now widely available and in conjunction with appropriate radionuclides and commercially available software make quantitative measurement of absolute MBF feasible for routine clinical practice. Quantitative measurement of absolute MBF under condition of coronary vasodilation permits independent assessment of the functional status of each of the three major coronary perfusion zones and so obviates the need for rest MBF determination in the great majority of cases. Coronary microvascular function also may be assessed in this same way. Thus, the stress-only protocol with quantitative PET measurement of MBF provides essential information required for clinical decision making related to need for catheterization and intervention for patients with known or suspected ischemic heart disease. Moreover, the single PET determination of maximal MBF in contrast to the usual rest/stress procedure addresses both safety and cost concerns. The present review focuses on: (1) quantitative PET measurements of myocardial blood flow for physiological assessment of the coronary circulation and (2) the value and potential limitations of performing stress only imaging in the clinical context.
C1 Harvard Univ, Massachusetts Gen Hosp, Sch Med, Div Cardiol,Dept Med,Cardiac Unit Yawkey 5E, Boston, MA 02114 USA.
C3 Harvard University; Harvard Medical School; Harvard University Medical
   Affiliates; Massachusetts General Hospital
RP Gewirtz, H (corresponding author), Harvard Univ, Massachusetts Gen Hosp, Sch Med, Div Cardiol,Dept Med,Cardiac Unit Yawkey 5E, Boston, MA 02114 USA.
EM hgewirtz@partners.org
FU FluoroPharma, Inc.
FX Research grant from FluoroPharma, Inc.
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NR 62
TC 15
Z9 17
U1 0
U2 6
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1071-3581
EI 1532-6551
J9 J NUCL CARDIOL
JI J. Nucl. Cardiol.
PD APR
PY 2012
VL 19
IS 2
BP 347
EP 354
DI 10.1007/s12350-011-9510-9
PG 8
WC Cardiac & Cardiovascular Systems; Radiology, Nuclear Medicine & Medical
   Imaging
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Radiology, Nuclear Medicine &
   Medical Imaging
GA 947CJ
UT WOS:000304403900020
PM 22231036
DA 2025-06-11
ER

PT J
AU Vancampfort, D
   Sienaert, P
   Wyckaert, S
   De Hert, M
   Stubbs, B
   Soundy, A
   De Smet, J
   Probst, M
AF Vancampfort, Davy
   Sienaert, Pascal
   Wyckaert, Sabine
   De Hert, Marc
   Stubbs, Brendon
   Soundy, Andrew
   De Smet, Jennifer
   Probst, Michel
TI Health-related physical fitness in patients with bipolar disorder vs.
   healthy controls: An exploratory study
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Physical fitness; Physical activity; Bipolar disorder
ID REPORT QIDS-SR; DEPRESSIVE SYMPTOMATOLOGY; METABOLIC SYNDROME; AUTONOMIC
   FUNCTION; QUICK INVENTORY; MENTAL-ILLNESS; RISK; SCHIZOPHRENIA;
   PARTICIPANTS; ASSOCIATIONS
AB Background: Low physical fitness has been recognized as a prominent behavioral risk factor for cardiovascular diseases and an independent risk factor for all cause mortality. To date, no studies have systematically assessed physical fitness in patients with bipolar disorder. The aim of the current study was to assess and compare the physical fitness in patients with bipolar disorder against healthy controls.
   Methods: Thirty patients with bipolar disorder (16 male, 40.8 +/- 11.6 years) and 30 age-, gender- and body mass index (BMI)-matched healthy controls were included. All participants performed the EurofiL Lest battery and the international Physical Activity Questionnaire. Patients were screened for psychiatric symptoms using the Quick inventory of Depressive SympLomarology and Hypornania Checklist-32.
   Results: Patients with bipolar disorder had a reduced speed of limb movement (15.8+/-5.7 vs. 11.8+/-2.2 s; p<0.001), explosive leg muscle strength (134.9 +/- 49.0 vs. 167.6 +/- 32.3 cm; p=0.003) and abdominal muscular endurance (11.5 +/- 7.8 vs. 18.3 +/- 7.6; p<0.001). Backward regression analyses demonstrated that longer illness duration, higher body mass index, higher levels of depression and a lower physical activity level explained the variance in physical fitness.
   Limitations: Our data are cross-sectional and cannot establish cause and effect.
   Conclusions: The current findings suggest that a lower physical fitness is emerging as an eminent modifiable risk factor for somatic co-morbidity in people with bipolar disorder. In particular less physically active persons, those with a longer illness duration and those with higher levels of depression might benefit from specific rehabilitation interventions aimed at increasing physical fitness. (C) 2015 Published by Elsevier B.V.
C1 [Vancampfort, Davy; De Smet, Jennifer; Probst, Michel] Univ Leuven, KU Leuven, Dept Rehabil Sci, B-3001 Leuven, Belgium.
   [Vancampfort, Davy; Sienaert, Pascal; Wyckaert, Sabine; De Hert, Marc; Probst, Michel] Univ Leuven, KU Leuven, Dept Neurosci, UPC KU Leuven, B-3070 Kortenberg, Belgium.
   [Stubbs, Brendon] Univ Greenwich, Sch Hlth & Social Care, London SE9 2UG, England.
   [Soundy, Andrew] Univ Birmingham, Dept Physiotherapy, Birmingham B15 2TT, W Midlands, England.
C3 KU Leuven; KU Leuven; University of Greenwich; University of Birmingham
RP Vancampfort, D (corresponding author), Univ Leuven, KU Leuven, Dept Rehabil Sci, Tervuursevest 101, B-3001 Leuven, Belgium.
EM davy.vancampfort@uc.kortenberg.be
RI Soundy, Andrew/H-3407-2019; sienaert, pascal/HTP-4217-2023; De Hert,
   Marc/AAH-6090-2021; Vancampfort, Davy/AAD-1987-2019; Probst,
   Michel/ABE-6137-2020; Stubbs, Brendon/X-1904-2018; Stubbs,
   Brendon/C-5696-2015
OI De Hert, Marc/0000-0003-4255-5920; Sienaert, Pascal/0000-0002-0650-415X;
   Stubbs, Brendon/0000-0001-7387-3791
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NR 36
TC 23
Z9 25
U1 0
U2 23
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD MAY 15
PY 2015
VL 177
BP 22
EP 27
DI 10.1016/j.jad.2014.12.058
PG 6
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA CF0NM
UT WOS:000352240900005
PM 25745831
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Ananthakrishnan, AN
   Long, MD
   Martin, CF
   Sandler, RS
   Kappelman, MD
AF Ananthakrishnan, Ashwin N.
   Long, Millie D.
   Martin, Christopher F.
   Sandler, Robert S.
   Kappelman, Michael D.
TI Sleep Disturbance and Risk of Active Disease in Patients With Crohn's
   Disease and Ulcerative Colitis
SO CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
LA English
DT Article
DE Intestinal Inflammation; Environment; PROMIS; Prospective Cohort Study
ID INFLAMMATORY-BOWEL-DISEASE; QUALITY-OF-LIFE; RHEUMATOID-ARTHRITIS;
   METABOLIC SYNDROME; ACTIVITY INDEX; FATIGUE; INTERLEUKIN-6;
   EPIDEMIOLOGY; DISABILITY; DEPRESSION
AB BACKGROUND & AIMS: Impairment of sleep quality is common in patients with inflammatory bowel diseases (IBDs) (eg, Crohn's disease [CD] and ulcerative colitis [UC]), even during clinical remission. Sleep impairment can activate inflammatory pathways. Few prospective studies have examined the role of sleep disturbance on risk of relapse in IBD.
   METHODS: We analyzed data from 3173 patients with IBD (1798 in clinical remission at baseline) participating in the Crohn's and Colitis Foundation of America Partners study, a longitudinal, Internet-based cohort. Sleep disturbance was measured using a subset of questions from the Patient Reported Outcomes Measurement Information Systems sleep disturbance questionnaire. Disease activity was assessed using the short Crohn's Disease Activity Index and the simple clinical colitis activity index for CD and UC, respectively. Logistic regression was used to identify predictors of sleep quality and examine the effect of sleep quality at baseline among patients in remission on risk of active disease at 6 months.
   RESULTS: Disease activity, depression, female sex, smoking, and use of corticosteroids or narcotics were associated with sleep disturbance at enrollment. Among 1291 patients whose CD was in remission at baseline, those with impaired sleep had a 2-fold increase in risk of active disease at 6 months (adjusted odds ratio, 2.00; 95% confidence interval, 1.45-2.76); however, no effect was observed in patients with UC (odds ratio, 1.14; 95% confidence interval, 0.75-1.74). These findings persisted in a number of sensitivity analyses.
   CONCLUSIONS: Sleep disturbance was associated with an increased risk of disease flares in CD but not UC. These findings indicate that the evaluation and treatment of sleep disturbance in patients with CD might improve outcomes.
C1 [Ananthakrishnan, Ashwin N.] Massachusetts Gen Hosp, Div Gastroenterol, Boston, MA 02114 USA.
   [Ananthakrishnan, Ashwin N.] Harvard Univ, Sch Med, Boston, MA USA.
   [Long, Millie D.; Martin, Christopher F.; Sandler, Robert S.] Univ N Carolina, Dept Med, Div Gastroenterol & Hepatol, Chapel Hill, NC USA.
   [Kappelman, Michael D.] Univ N Carolina, Dept Pediat, Div Gastroenterol, Chapel Hill, NC USA.
C3 Harvard University; Harvard University Medical Affiliates; Massachusetts
   General Hospital; Harvard University; Harvard Medical School; University
   of North Carolina; University of North Carolina Chapel Hill; University
   of North Carolina; University of North Carolina Chapel Hill
RP Ananthakrishnan, AN (corresponding author), Massachusetts Gen Hosp, Crohns & Colitis Ctr, 165 Cambridge St,9th Floor, Boston, MA 02114 USA.
EM aananthakrishnan@partners.org
FU National Institutes of Health [K23 DK097142, P30 DK34987]; Crohn's and
   Colitis Foundation of America
FX Supported in part by a grant from the National Institutes of Health (K23
   DK097142 to A.N.A.), and the Crohn's and Colitis Foundation of America
   Partners cohort is supported by grants from the Crohn's and Colitis
   Foundation of America and the National Institutes of Health (P30
   DK34987).
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NR 41
TC 184
Z9 205
U1 1
U2 37
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1542-3565
J9 CLIN GASTROENTEROL H
JI Clin. Gastroenterol. Hepatol.
PD AUG
PY 2013
VL 11
IS 8
BP 965
EP 971
DI 10.1016/j.cgh.2013.01.021
PG 7
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 195MP
UT WOS:000322707100017
PM 23376797
OA Green Published, Green Accepted
DA 2025-06-11
ER

PT J
AU Weaver, JB
   Mays, D
   Weaver, SS
   Kannenberg, W
   Hopkins, GL
   Eroglu, D
   Bernhardt, JM
AF Weaver, James B., III
   Mays, Darren
   Weaver, Stephanie Sargent
   Kannenberg, Wendi
   Hopkins, Gary L.
   Eroglu, Dogan
   Bernhardt, Jay M.
TI Health-Risk Correlates of Video-Game Playing Among Adults
SO AMERICAN JOURNAL OF PREVENTIVE MEDICINE
LA English
DT Article
ID MOOD-MANAGEMENT; SELECTIVE EXPOSURE; METABOLIC SYNDROME; TELEVISION;
   TIME; COMPUTER; ADOLESCENTS; ADDICTION; INTERNET
AB Background: Although considerable research suggests that health-risk factors vary as a function of video-game playing among young people, direct evidence of such linkages among adults is lacking.
   Purpose: The goal of this Study was to distinguish adult video-game players from nonplayers on the basis of personal and environmental factors. It was hypothesized that adults who play video games, compared to nonplayers, would evidence poorer perceptions of their health, greater reliance on Internet-facilitated social support, more extensive media use, and higher BMI. It was further hypothesized that different patterns of linkages between video-game playing and health-risk factors would emerge by gender.
   Methods: A cross-sectional, Internet-based survey was conducted in 2006 with a sample of adults from the Seattle-Tacoma area (n=562), examining health risks; media use behaviors and perceptions, including those related to video-game playing; and demographics. Statistical analyses conducted in 2008 to compare video-game players and nonplayers included bivariate descriptive statistics, stepwise discriminant analysis, and ANOVA.
   Results: A total of 45.1% of respondents reported playing video games. Female video-game players reported greater depression (M=1.57) and poorer health status (M=3.90) than female nonplayers (depression, M=1.13; health status, M=3.57). Male video-game players reported higher BMI (M=5.31) and more Internet use time (M=2.55) than male nonplayers (BMI, M=5.19; Internet use, M=2.36). The only determinant common to female and male video-game players was greater reliance on the Internet for social support.
   Conclusions: A number of determinants distinguished video-game players from nonplayers, and these factors differed substantially between men and women. The data illustrate the need for further research among adults to clarify how to use digital opportunities more effectively to promote health and prevent disease. (Am J Prev Med 2009;37(4):299-305) (C) 2009 American journal of Preventive Medicine
C1 [Weaver, James B., III; Mays, Darren; Weaver, Stephanie Sargent; Eroglu, Dogan; Bernhardt, Jay M.] CDC, Natl Ctr Hlth Mkt, Atlanta, GA 30333 USA.
   [Mays, Darren] Emory Univ, Rollins Sch Publ Hlth, Dept Behav Sci & Hlth Educ, Atlanta, GA 30322 USA.
   [Kannenberg, Wendi; Hopkins, Gary L.] Andrews Univ, Inst Prevent Addict, Ctr Media Impact Res, Berrien Springs, MI 49104 USA.
C3 Centers for Disease Control & Prevention - USA; Emory University;
   Rollins School Public Health; Andrews University
RP Weaver, JB (corresponding author), CDC, Natl Ctr Hlth Mkt, 1600 Clifton Rd,MS-E21, Atlanta, GA 30333 USA.
EM jim.weaver@cdc.gov
OI Bernhardt, Jay/0000-0002-2045-4005
FU Center for Media Impact Research
FX The authors are indebted to Richard E. Dixon, Marinella Marci, Duane C.
   McBride, andjohn V. StevensJr. for their significant contributions to
   this project. This research was supported in part by a grant from the
   Center for Media Impact Research in the Institute for Prevention of
   Addictions at Andrews University and by appointments of JBW, DM, and SSW
   to the Research Participation Program at the CDC administered by the Oak
   Ridge Institute for Science and Education through an interagency
   agreement
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NR 51
TC 60
Z9 75
U1 0
U2 33
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0749-3797
EI 1873-2607
J9 AM J PREV MED
JI Am. J. Prev. Med.
PD OCT
PY 2009
VL 37
IS 4
BP 299
EP 305
DI 10.1016/j.amepre.2009.06.014
PG 7
WC Public, Environmental & Occupational Health; Medicine, General &
   Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; General & Internal Medicine
GA 500WO
UT WOS:000270336800006
PM 19765501
DA 2025-06-11
ER

PT J
AU Fernandez-Lazaro, CI
   Toledo, E
   Buil-Cosiales, P
   Salas-Salvadó, J
   Corella, D
   Fitó, M
   Martínez, JA
   Alonso-Gómez, AM
   Wärnberg, J
   Vioque, J
   Romaguera, D
   López-Miranda, J
   Estruch, R
   Tinahones, FJ
   Lapetra, J
   Serra-Majem, L
   Bueno-Cavanillas, A
   Tur, JA
   Sánchez, VM
   Pintó, X
   Delgado-Rodríguez, M
   Matía-Martín, P
   Vidal, J
   Ros, E
   Vázquez, C
   Daimiel, L
   SanJulián, B
   García-Gavilán, JF
   Sorlí, J
   Castañer, O
   Zulet, MA
   Tojal-Sierra, L
   Pérez-Farinós, N
   Oncina-Canovas, A
   Moñino, M
   Garcia-Rios, A
   Sacanella, E
   Bernal-Lopez, RM
   Santos-Lozano, JM
   Vázquez-Ruiz, Z
   Muralidharan, J
   Ortega-Azorín, C
   Goday, A
   Razquin, C
   Goicolea-Güemez, L
   Ruiz-Canela, M
   Becerra-Tomás, N
   Schröder, H
   González, MAM
AF Fernandez-Lazaro, Cesar, I
   Toledo, Estefania
   Buil-Cosiales, Pilar
   Salas-Salvado, Jordi
   Corella, Dolores
   Fito, Montserrat
   Alfredo Martinez, J.
   Alonso-Gomez, Angel M.
   Warnberg, Julia
   Vioque, Jesus
   Romaguera, Dora
   Lopez-Miranda, Jose
   Estruch, Ramon
   Tinahones, Francisco J.
   Lapetra, Jose
   Serra-Majem, Luis
   Bueno-Cavanillas, Aurora
   Tur, Josep A.
   Martin Sanchez, Vicente
   Pinto, Xavier
   Delgado-Rodriguez, Miguel
   Matia-Martin, Pilar
   Vidal, Josep
   Ros, Emilio
   Vazquez, Clotilde
   Daimiel, Lidia
   SanJulian, Beatriz
   Garcia-Gavilan, Jesus F.
   Sorli, Jose, V
   Castaner, Olga
   Angeles Zulet, M.
   Tojal-Sierra, Lucas
   Perez-Farinos, Napoleon
   Oncina-Canovas, Alejandro
   Monino, Manuel
   Garcia-Rios, Antonio
   Sacanella, Emilio
   Bernal-Lopez, Rosa M.
   Manuel Santos-Lozano, Jose
   Vazquez-Ruiz, Zenaida
   Muralidharan, Jananee
   Ortega-Azorin, Carolina
   Goday, Alberto
   Razquin, Cristina
   Goicolea-Guemez, Leire
   Ruiz-Canela, Miguel
   Becerra-Tomas, Nerea
   Schroder, Helmut
   Martinez Gonzalez, Miguel A.
CA PREDIMED-Plus Investigators
TI Factors associated with successful dietary changes in an energy-reduced
   Mediterranean diet intervention: a longitudinal analysis in the
   PREDIMED-Plus trial
SO EUROPEAN JOURNAL OF NUTRITION
LA English
DT Article
DE PREDIMED-Plus; Dietary change; Factors; Dietary adherence; Mediterranean
   diet; Randomized controlled trials
ID WEIGHT-LOSS; CARDIOVASCULAR-DISEASE; BREAST-CANCER; ADHERENCE; HEALTH;
   PATTERN; RISK; FAT; QUESTIONNAIRE; POPULATION
AB Purpose Long-term nutrition trials may fail to respond to their original hypotheses if participants do not comply with the intended dietary intervention. We aimed to identify baseline factors associated with successful dietary changes towards an energy-reduced Mediterranean diet (MedDiet) in the PREDIMED-Plus randomized trial.
   Methods Longitudinal analysis of 2985 participants (Spanish overweight/obese older adults with metabolic syndrome) randomized to the active intervention arm of the PREDIMED-Plus trial. Dietary changes were assessed with a 17-item energy-reduced MedDiet questionnaire after 6 and 12 months of follow-up. Successful compliance was defined as dietary changes from baseline of >= 5 points for participants with baseline scores < 13 points or any increase if baseline score was >= 13 points. We conducted crude and adjusted multivariable logistic regression models to identify baseline factors related to compliance.
   Results Consistent factors independently associated with successful dietary change at both 6 and 12 months were high baseline perceived self-efficacy in modifying diet (OR6-month: 1.51, 95% CI 1.25-1.83; OR12-month: 1.66, 95% CI 1.37-2.01), higher baseline fiber intake (OR6-month: 1.62, 95% CI 1.07-2.46; OR12-month: 1.62, 95% CI 1.07-2.45), having > 3 chronic conditions (OR6-month: 0.65, 95% CI 0.53-0.79; OR12-month: 0.76, 95% CI 0.62-0.93), and suffering depression (OR6-month: 0.80, 95% CI 0.64-0.99; OR12-month: 0.71, 95% CI 0.57-0.88).
   Conclusion Our results suggested that recruitment of individuals with high perceived self-efficacy to dietary change, and those who initially follow diets relatively richer in fiber may lead to greater changes in nutritional recommendations. Participants with multiple chronic conditions, specifically depression, should receive specific tailored interventions.
C1 [Fernandez-Lazaro, Cesar, I; Toledo, Estefania; Buil-Cosiales, Pilar; SanJulian, Beatriz; Vazquez-Ruiz, Zenaida; Razquin, Cristina; Ruiz-Canela, Miguel; Martinez Gonzalez, Miguel A.] NavarraUniv Navarra, Dept Prevent Med & Publ Hlth, IdiSNA, Pamplona 31008, Spain.
   [Toledo, Estefania; Buil-Cosiales, Pilar; Salas-Salvado, Jordi; Corella, Dolores; Fito, Montserrat; Alfredo Martinez, J.; Alonso-Gomez, Angel M.; Warnberg, Julia; Romaguera, Dora; Lopez-Miranda, Jose; Estruch, Ramon; Tinahones, Francisco J.; Lapetra, Jose; Serra-Majem, Luis; Tur, Josep A.; Pinto, Xavier; Ros, Emilio; Garcia-Gavilan, Jesus F.; Sorli, Jose, V; Castaner, Olga; Angeles Zulet, M.; Tojal-Sierra, Lucas; Perez-Farinos, Napoleon; Monino, Manuel; Garcia-Rios, Antonio; Sacanella, Emilio; Bernal-Lopez, Rosa M.; Manuel Santos-Lozano, Jose; Vazquez-Ruiz, Zenaida; Muralidharan, Jananee; Ortega-Azorin, Carolina; Goday, Alberto; Razquin, Cristina; Goicolea-Guemez, Leire; Ruiz-Canela, Miguel; Becerra-Tomas, Nerea; Schroder, Helmut; Martinez Gonzalez, Miguel A.] Inst Hlth Carlos III, Ctr Invest Biomed Red Fisiopatol Obesidad & Nutr, Madrid, Spain.
   [Buil-Cosiales, Pilar] IdiSNA, Serv Atenc Primaria, Navarra Reg Hlth Serv Osasunbidea, Pamplona, Spain.
   [Salas-Salvado, Jordi; Garcia-Gavilan, Jesus F.; Muralidharan, Jananee; Becerra-Tomas, Nerea] Univ Rovira & Virgili, Dept Bioquim & Biotecnol, Unitat Nutr Humana, Reus, Spain.
   [Salas-Salvado, Jordi] Univ Hosp St Joan Reus, Nutr Unit, Reus, Spain.
   [Salas-Salvado, Jordi; Becerra-Tomas, Nerea] Inst Invest Sanitaria Pere Virgili IISPV, Reus, Spain.
   [Corella, Dolores; Sorli, Jose, V; Ortega-Azorin, Carolina] Univ Valencia, Dept Prevent Med, Valencia, Spain.
   [Fito, Montserrat; Castaner, Olga; Goday, Alberto; Schroder, Helmut] Inst Hosp Mar Invest Med Municipal Invest Med IMI, Unit Cardiovasc Risk & Nutr, Barcelona, Spain.
   [Alfredo Martinez, J.] Univ Navarra, Ctr Nutr Res, Dept Nutr Food Sci & Physiol, Pamplona, Spain.
   [Alfredo Martinez, J.; Angeles Zulet, M.] CEI UAM CSIC, IMDEA Food, Cardiometab Nutr Grp, Madrid, Spain.
   [Alonso-Gomez, Angel M.; Tojal-Sierra, Lucas; Goicolea-Guemez, Leire] Univ Basque Country UPV EHU, Araba Univ Hosp, Bioaraba Hlth Res Inst, Cardiovasc Resp & Metab Area,Osakidetza Basque Hl, Vitoria, Spain.
   [Warnberg, Julia; Perez-Farinos, Napoleon] Univ Malaga, Sch Hlth Sci, Inst Invest Biomed Malaga IBIMA, Epiphaan Res Grp, Malaga 29071, Spain.
   [Vioque, Jesus; Bueno-Cavanillas, Aurora; Martin Sanchez, Vicente; Delgado-Rodriguez, Miguel] Inst Salud Carlos III, CIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain.
   [Vioque, Jesus; Oncina-Canovas, Alejandro] Inst Invest Sanitaria & Biomed Alicante ISABIAL U, Alicante, Spain.
   [Romaguera, Dora; Monino, Manuel] Hlth Res Inst Balearic Isl IdISBa, Palma De Mallorca, Spain.
   [Lopez-Miranda, Jose; Garcia-Rios, Antonio] Univ Cordoba, Reina Sofia Univ Hosp, Maimonides Biomed Res Inst Cordoba IMIBIC, Dept Internal Med, Cordoba, Spain.
   [Estruch, Ramon; Sacanella, Emilio] Univ Barcelona, Hosp Clin, Inst Invest Biomed August Pi Sunyer IDIBAPS, Dept Internal Med, Barcelona, Spain.
   [Tinahones, Francisco J.; Bernal-Lopez, Rosa M.] Univ Malaga, Virgen de la Victoria Hosp, Inst Invest Biomed Malaga IBIMA, Dept Endocrinol, Malaga, Spain.
   [Lapetra, Jose; Manuel Santos-Lozano, Jose] Dist Sanitario Atenc Primaria Sevilla, Res Unit, Dept Family Med, Seville, Spain.
   [Serra-Majem, Luis] Univ Las Palmas Gran Canaria, Res Inst Biomed & Hlth Sci IUIBS, Las Palmas Gran Canaria, Spain.
   [Serra-Majem, Luis] Ctr Hosp Univ Insular Materno Infantil CHUIMI, Canarian Hlth Serv, Las Palmas Gran Canaria, Spain.
   [Bueno-Cavanillas, Aurora] Univ Granada, Dept Prevent Med & Publ Hlth, Granada, Spain.
   [Tur, Josep A.] Univ Balearic Isl IUNICS, Res Grp Community Nutr & Oxidat Stress, Palma De Mallorca, Spain.
   [Tur, Josep A.] IDISBA, Palma De Mallorca, Spain.
   [Martin Sanchez, Vicente] Univ Leon, Inst Biomed IBIOMED, Leon, Spain.
   [Pinto, Xavier] Hosp Univ Bellvitge, Lipids & Vasc Risk Unit, Internal Med, Barcelona, Spain.
   [Delgado-Rodriguez, Miguel] Univ Jaen, Fac Med, Div Prevent Med, Jaen, Spain.
   [Matia-Martin, Pilar] Inst Invest Sanitaria Hosp Clin San Carlos IdISSC, Dept Endocrinol & Nutr, Madrid, Spain.
   [Vidal, Josep] Inst Salud Carlos III ISCIII, CIBER Diabet & Enfermedades Metab CIBERDEM, Madrid, Spain.
   [Vidal, Josep; Ros, Emilio] Univ Barcelona, Hosp Clin, Inst Invest Biomed August Pi Sunyer IDIBAPS, Dept Endocrinol, Barcelona, Spain.
   [Ros, Emilio] Hosp Clin Barcelona, Inst Invest Biomed August Pi Sunyer IDIBAPS, Dept Endocrinol & Nutr, Lipid Clin, Barcelona, Spain.
   [Vazquez, Clotilde] Univ Autonoma, Hosp Fdn Jimenez Diaz, Inst Invest Biomed IISFJD, Dept Endocrinol & Nutr, Madrid, Spain.
   [Daimiel, Lidia] CEI UAM CSIC, IMDEA Food, Nutr Control Epigenome Grp, Madrid, Spain.
   [Martinez Gonzalez, Miguel A.] Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA.
C3 CIBER - Centro de Investigacion Biomedica en Red; CIBEROBN; Universitat
   Rovira i Virgili; Universitat Rovira i Virgili; Institut d'Investigacio
   Sanitaria Pere Virgili (IISPV); University of Valencia; University of
   Navarra; Consejo Superior de Investigaciones Cientificas (CSIC); IMDEA
   Food Institute; Bioaraba Health Research Institute; University Hospital
   of Araba; University of Basque Country; Instituto de Investigacion
   Biomedica de Malaga y Plataforma en Nanomedicina (IBIMA); Universidad de
   Malaga; Instituto de Salud Carlos III; CIBER - Centro de Investigacion
   Biomedica en Red; CIBERESP; General University Hospital of Alicante;
   Universidad Miguel Hernandez de Elche; Universitat d'Alacant; Instituto
   de Investigacion Sanitaria y Biomedica de Alicante (ISABIAL); Institut
   Investigacio Sanitaria Illes Balears (IdISBa); Universidad de Cordoba;
   University of Barcelona; Hospital Clinic de Barcelona; IDIBAPS;
   Instituto de Investigacion Biomedica de Malaga y Plataforma en
   Nanomedicina (IBIMA); Universidad de Malaga; Universidad de Las Palmas
   de Gran Canaria; University of Granada; Institut Investigacio Sanitaria
   Illes Balears (IdISBa); Universidad de Leon; Institut d'Investigacio
   Biomedica de Bellvitge (IDIBELL); Bellvitge University Hospital;
   University of Barcelona; Universidad de Jaen; CIBER - Centro de
   Investigacion Biomedica en Red; CIBERDEM; University of Barcelona;
   Hospital Clinic de Barcelona; IDIBAPS; University of Barcelona; Hospital
   Clinic de Barcelona; IDIBAPS; Autonomous University of Madrid; Fundacion
   Jimenez Diaz; Consejo Superior de Investigaciones Cientificas (CSIC);
   IMDEA Food Institute; Harvard University; Harvard T.H. Chan School of
   Public Health
RP González, MAM (corresponding author), NavarraUniv Navarra, Dept Prevent Med & Publ Hlth, IdiSNA, Pamplona 31008, Spain.; González, MAM (corresponding author), Inst Hlth Carlos III, Ctr Invest Biomed Red Fisiopatol Obesidad & Nutr, Madrid, Spain.; González, MAM (corresponding author), Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA.
EM mamartinez@unav.es
RI Vioque, Jesus/A-1066-2008; Corella, Dolores/L-9888-2014; ALONSO GOMEZ,
   ANGEL/HLG-2476-2023; Bueno-Cavanillas, Aurora/O-1513-2015; Tinahones,
   Francisco/AAB-2882-2020; Estruch, Ramon/AAZ-3723-2020; Warnberg,
   Julia/G-1390-2011; García-Gavilán, Jesús/ABG-9982-2020; Pintó,
   Xavier/AGI-4297-2022; Razquin, Cristina/H-2366-2017; Sorlí,
   José/L-8758-2014; Moñino, Manuel/IWV-3973-2023; Zulet, M./H-1317-2017;
   Vidal, Josep/MIK-6936-2025; Ruiz-Canela, Miguel/JYP-1794-2024;
   Rodríguez, Miguel/KCZ-1828-2024; Lapetra, Jose/F-2552-2015; Tur,
   Josep/AAE-5748-2020; Fernandez-Lazaro, Cesar/V-6390-2019; Tejada,
   Silvia/L-7297-2014; Castaner, Olga/F-1533-2013; Ortega-Azorín,
   Carolina/AAB-2355-2019; Martínez, J./K-8709-2014; Oncina Canovas,
   Alejandro/KOD-0906-2024; Romaguera, Dora/ABE-7004-2020; Lopez-Miranda,
   Jose/Y-8306-2019; Toledo, Estefania/H-6211-2014; Becerra-Tomas,
   Nerea/H-3937-2018; Fito Colomer, Montse/C-1822-2012; Schroder,
   Helmut/G-2586-2015; Fernandez Garcia, Jose Carlos/B-3723-2013; Delgado
   Rodriguez, Miguel/H-4940-2017; Vazquez-Ruiz, Zenaida/AAB-7202-2020;
   Martin, Vicente/A-1597-2008; Salas-Salvado, Jordi/C-7229-2017;
   Daimiel-Ruiz, Lidia Angeles/M-7779-2014
OI Toledo, Estefania/0000-0002-6263-4434; Monino,
   Manuel/0000-0003-1230-8013; Oncina Canovas,
   Alejandro/0000-0003-4652-0565; Becerra-Tomas, Nerea/0000-0002-4429-6507;
   Tojal Sierra, Lucas/0000-0001-5338-9601; Fito Colomer,
   Montse/0000-0002-1817-483X; Schroder, Helmut/0000-0003-2231-5081; Sorli,
   Jose V/0000-0002-0130-2006; Fernandez Garcia, Jose
   Carlos/0000-0003-2308-2865; Delgado Rodriguez,
   Miguel/0000-0002-3838-2548; Garcia-Gavilan, Jesus
   Francisco/0000-0002-3707-5255; MARTINEZ PEREZ, MARIA
   MAGDALENA/0009-0003-9227-8404; Vioque, Jesus/0000-0002-2284-148X;
   Buil-Cosiales, Pilar/0000-0002-8586-577X; Tinahones, Francisco
   J/0000-0001-6871-4403; Vazquez-Ruiz, Zenaida/0000-0002-6828-9627;
   Lopez-Miranda, Jose/0000-0002-8844-0718; Martin,
   Vicente/0000-0003-0552-2804; Salas-Salvado, Jordi/0000-0003-2700-7459;
   Tercero Macia, Cristina/0009-0000-6092-9231; Daimiel-Ruiz, Lidia
   Angeles/0000-0001-9898-6629
FU CRUE-CSIC; Springer Nature; European Research Council [340918]; CIBER
   Fisiopatologia de la Obesidad y Nutricion (CIBERobn); Instituto de Salud
   Carlos III (ISCIII), through the Fondo de Investigacion en Salud (FIS) -
   European Regional Development Fund [PI13/00673, PI13/00492, PI13/00272,
   PI13/01123, PI13/00462, PI13/00233, PI13/02184, PI13/00728, PI13/01090,
   PI13/01056, PI14/01722, PI14/00636, PI14/00618, PI14/00696, PI14/01206,
   PI14/01919, PI14/00853, PI14/01374, PI14/00972]; Instituto de Salud
   Carlos III (ISCIII), through the Fondo de Investigacion en Salud (FIS) -
   the European Regional Development Fund [PI14/00728, PI14/01471,
   PI16/00473, PI16/00662, PI16/01873, PI16/01094, PI16/00501, PI16/00533,
   PI16/00381, PI16/00366, PI16/01522, PI16/01120, PI17/00764, PI17/01183,
   PI17/00855, PI17/01347, PI17/00525, PI17/01827]; Instituto de Salud
   Carlos III (ISCIII), through the Fondo de Investigacion en Salud (FIS) -
   'European Regional Development Fund' [PI17/00532, PI17/00215,
   PI17/01441, PI17/00508, PI17/01732, PI17/00926, PI19/00957, PI19/00386,
   PI19/00309, PI19/01032, PI19/00576, PI19/00017]; Especial Action Project
   entitled Implementacion y evaluacion de una intervencion intensiva sobre
   la actividad fisica Cohorte PREDIMED-Plus grant; Recercaixa grant
   [2013ACUP00194]; Consejeria de Salud de la Junta de Andalucia;
   Generalitat Valenciana; SEMERGEN grant; International Nut Dried Fruit;
   AstraZeneca; ICREA under the ICREA Academia programme; European Regional
   Development Fund [CB06/03, CB12/03]; Instituto de Salud Carlos III
   (ISCIII), through the Fondo de Investigacion en Salud (FIS) - the
   'European Regional Development Fund' [PI19/01226, PI19/00781,
   PI19/01560, PI19/01332, PI20/01802, PI20/00138, PI20/01532, PI20/00456,
   PI20/00339, PI20/00557, PI20/00886, PI20/01158];  [T2D 2017]
FX Open Access funding provided thanks to the CRUE-CSIC agreement with
   Springer Nature. The PREDIMED-Plus trial was supported by the European
   Research Council (advanced research grant 2014-2019, 340918 to MAM-G as
   PI) and by the official Spanish Institutions for funding scientific
   biomedical research, CIBER Fisiopatologia de la Obesidad y Nutricion
   (CIBERobn) and Instituto de Salud Carlos III (ISCIII), through the Fondo
   de Investigacion en Salud (FIS), which is cofunded by the European
   Regional Development Fund coordinated by J. S.-S. and J.V., including
   the following projects: PI13/00673, PI13/00492, PI13/00272, PI13/01123,
   PI13/00462, PI13/00233, PI13/02184, PI13/00728, PI13/01090, PI13/01056,
   PI14/01722, PI14/00636, PI14/00618, PI14/00696, PI14/01206, PI14/01919,
   PI14/00853, PI14/01374, PI14/00972, PI14/00728, PI14/01471, PI16/00473,
   PI16/00662, PI16/01873, PI16/01094, PI16/00501, PI16/00533, PI16/00381,
   PI16/00366, PI16/01522, PI16/01120, PI17/00764, PI17/01183, PI17/00855,
   PI17/01347, PI17/00525, PI17/01827, PI17/00532, PI17/00215, PI17/01441,
   PI17/00508, PI17/01732, PI17/00926, PI19/00957, PI19/00386, PI19/00309,
   PI19/01032, PI19/00576, PI19/00017, PI19/01226, PI19/00781, PI19/01560,
   PI19/01332, PI20/01802, PI20/00138, PI20/01532, PI20/00456, PI20/00339,
   PI20/00557, PI20/00886, and PI20/01158); the Especial Action Project
   entitled Implementacion y evaluacion de una intervencion intensiva sobre
   la actividad fisica Cohorte PREDIMED-Plus grant, the Recercaixa grant
   (2013ACUP00194), Grants from the Consejeria de Salud de la Junta de
   Andalucia, a grant from the Generalitat Valenciana, a SEMERGEN grant,
   and funds from the European Regional Development Fund (CB06/03;
   CB12/03), The International Nut & Dried Fruit; and the AstraZeneca Young
   Investigators Award in Category of Obesity and T2D 2017 to DR. J.S.-S.
   is partially supported by ICREA under the ICREA Academia programme. None
   of the funding sources took part in the design, collection, analysis, or
   interpretation of the data or in the decision to submit the manuscript
   for publication.
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NR 48
TC 13
Z9 13
U1 2
U2 24
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1436-6207
EI 1436-6215
J9 EUR J NUTR
JI Eur. J. Nutr.
PD APR
PY 2022
VL 61
IS 3
BP 1457
EP 1475
DI 10.1007/s00394-021-02697-8
EA NOV 2021
PG 19
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nutrition & Dietetics
GA ZT0WD
UT WOS:000724070900002
PM 34846603
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Miner, MM
   Bhattacharya, RK
   Blick, G
   Kushner, H
   Khera, M
AF Miner, Martin M.
   Bhattacharya, Rajib K.
   Blick, Gary
   Kushner, Harvey
   Khera, Mohit
TI 12-Month Observation of Testosterone Replacement Effectiveness in a
   General Population of Men
SO POSTGRADUATE MEDICINE
LA English
DT Article
DE testosterone deficiency; hypogonadism; testosterone replacement therapy;
   testosterone gel; TRiUS registry
ID ANDROGEN DEFICIENCY SYNDROMES; CLINICAL-PRACTICE GUIDELINE; SEXUAL
   FUNCTION INVENTORY; LATE-ONSET HYPOGONADISM; UNITED-STATES TRIUS; TESTIM
   REGISTRY; METABOLIC SYNDROME; BODY-COMPOSITION; US TRIUS; TRANSDERMAL
   TESTOSTERONE
AB Background: Testosterone decline becomes more prevalent as men age and symptomatic testosterone deficiency is associated with potentially serious comorbidities. Despite limitations, registries can provide an opportunity to accumulate data regarding disease management in a typical patient population, including diagnosis, treatment, and outcomes. Materials and Methods: The Testim Registry in the United States (TRiUS) was a prospective, 12-month, observational cohort registry of men prescribed Testim (R) (1% testosterone gel; Auxilium Pharmaceuticals, Inc.) for the first time; patients previously on other forms of testosterone replacement therapy (TRT) were eligible to participate in the study as well. The registry recorded total testosterone (TT) and free testosterone (FT) levels, prostate-specific antigen (PSA), sexual function, mood/depression, and cardiometabolic and anthropometric criteria before and after TRT. Changes over time were analyzed by analysis of variance, and linear regression and Pearson product-moment correlation coefficients were used to examine relationships between variables. Results: At baseline, 849 patients from 72 sites were enrolled, with 743 of 849 started on 5 g gel/day (50 mg testosterone/day) and 106 of 849 started on 10 g gel/day (100 mg testosterone/day). Mean TT and FT levels increased significantly after 3 months of TRT (TT level, 16.8 +/- 9.87 nmol/L [485 +/- 284 ng/dL], P < 0.001; FT level, 286.3 +/- 224.9 pmol/L [82.5 +/- 64.8 pg/mL], P < 0.001) and were maintained at eugonadal levels. Mean PSA levels increased significantly (P = 0.004) from 1.12 +/- 1.11 mu g/L (1.12 +/- 1.11 ng/mL) at baseline to 1.26 +/- 1.22 mu g/L (1.26 +/- 1.22 ng/mL) after 12 months of TRT, although changes were well within guidelines (< 1.4 mu g/L/year increase). Significant improvements were seen in sexual function and mood/depression at 3 months and in metabolic parameters at 12 months. Conclusion: Testosterone deficiency symptoms improved with TRT use in men; sexual function and mood/depression improvements were seen before metabolic improvements. Prostate-specific antigen levels increased, although increases were within guideline-determined safety limits.
C1 [Miner, Martin M.] Brown Univ, Warren Alpert Sch Med, Providence, RI 02912 USA.
   [Miner, Martin M.] Miriam Hosp, Mens Hlth Ctr, Providence, RI 02906 USA.
   [Bhattacharya, Rajib K.] Univ Kansas, Med Ctr, Dept Internal Med, Kansas City, KS 66103 USA.
   [Blick, Gary] Circle Med LLC, Norwalk, CT USA.
   [Kushner, Harvey] Auxilium Pharmaceut, Malvern, PA USA.
   [Khera, Mohit] Baylor Coll Med, Scott Dept Urol, Houston, TX 77030 USA.
C3 Brown University; Lifespan Health Rhode Island; Miriam Hospital;
   University of Kansas; University of Kansas Medical Center; Baylor
   College of Medicine
RP Miner, MM (corresponding author), Brown Univ, Warren Alpert Sch Med, Providence, RI 02912 USA.
FU Auxilium Pharmaceuticals, Inc.
FX The authors thank Tara Gupta, PhD, and Sherri D. Jones, PharmD, of
   MedVal Scientific Information Services, LLC, for medical writing and
   editorial assistance. Funding for the TRiUS registry and support for the
   preparation of this manuscript was provided by Auxilium Pharmaceuticals,
   Inc. All authors had access to the data and a role in writing the
   manuscript, and were involved in the conception and design of the study
   and the analysis of the data.
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NR 41
TC 21
Z9 22
U1 0
U2 4
PU JTE MULTIMEDIA
PI WEST CONSHOHOCKEN
PA 18 ELIZABETH ST, STE 110, WEST CONSHOHOCKEN, PA 19428 USA
SN 0032-5481
EI 1941-9260
J9 POSTGRAD MED
JI Postgrad. Med.
PD MAR
PY 2013
VL 125
IS 2
DI 10.3810/pgm.2013.03.2637
PG 11
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA AX2SJ
UT WOS:000346794200001
PM 23816767
DA 2025-06-11
ER

PT J
AU Elmarakby, AA
   Imig, JD
AF Elmarakby, Ahmed A.
   Imig, John D.
TI Obesity is the major contributor to vascular dysfunction and
   inflammation in high-fat diet hypertensive rats
SO CLINICAL SCIENCE
LA English
DT Article
DE angiotensin II; high-fat diet; hypertension; inflammation; obesity;
   oxidative stress; vascular dysfunction
ID TUMOR-NECROSIS-FACTOR; INDUCED-INSULIN-RESISTANCE; NF-KAPPA-B;
   ANGIOTENSIN-II; OXIDATIVE STRESS; ENDOTHELIAL DYSFUNCTION; RENAL INJURY;
   FACTOR-ALPHA; ANTIOXIDANT ENZYMES; METABOLIC SYNDROME
AB Obesity and hypertension are the two major risk factors that contribute to the progression of end-stage renal disease. To examine whether hypertension further exacerbates oxidative stress and vascular dysfunction and inflammation in obese rats, four groups of male Sprague-Dawley rats were fed either a normal (7% fat) or high-fat (36% fat) diet for 6 weeks and osmotic pumps were implanted to deliver ANG (angiotensin II) or vehicle for an additional 4 weeks. Treatment with the high-fat diet did not alter ANG-induced hypertension compared with the normal diet (174 +/- 6 compared with 170 +/- 5 mmHg respectively). Treatment with the high-fat diet increased body weight gain and plasma leptin levels and induced insulin resistance in normotensive and ANG-induced hypertensive rats. Plasma TBARS (thiobarbituric acid-reacting substances), a measure of oxidative stress, were elevated in high-fat diet-fed rats compared with controls (11.2 +/- 1 compared with 8.4 +/- 1 nmol/ml respectively) and was increased further in ANG-induced hypertensive rats fed a high-fat diet (18.8 +/- 2.2 nmol/ml). Urinary nitrite excretion was also decreased in rats fed a high-fat diet without or with ANG infusion compared with controls. Afferent arteriolar relaxation to acetylcholine was impaired in rats fed the high-fat diet without or with ANG infusion. Renal cortical TNF-alpha (tumour necrosis factor-alpha), COX-2 (cyclo-oxygenase-2) and phospho-IKK (inhibitor of nuclear factor kappa B kinase) expression increased in high-fat diet-fed rats compared with normal diet-fed rats. The increases in phospho-IKK and COX-2 expression were elevated further in ANG-induced hypertensive rats fed the high-fat diet. These results suggest that ANG-induced hypertension exacerbates oxidative stress and renal inflammation without further impairment in vascular dysfunction in high-fat diet-induced obesity.
C1 [Elmarakby, Ahmed A.] Med Coll Georgia, Dept Oral Biol Pharmacol, Augusta, GA 30912 USA.
   [Elmarakby, Ahmed A.] Med Coll Georgia, Vasc Biol Ctr, Augusta, GA 30912 USA.
   [Imig, John D.] Med Coll Wisconsin, Dept Pharmacol & Toxicol, Milwaukee, WI 53226 USA.
   [Imig, John D.] Med Coll Wisconsin, Cardiovasc Res Ctr, Milwaukee, WI 53226 USA.
C3 University System of Georgia; Augusta University; University System of
   Georgia; Augusta University; Medical College of Wisconsin; Medical
   College of Wisconsin
RP Elmarakby, AA (corresponding author), Med Coll Georgia, Dept Oral Biol Pharmacol, Augusta, GA 30912 USA.
EM aelmarakby@mcg.edu
RI Elmarakby, Ahmed/ABF-5055-2021
OI Imig, John/0000-0002-9668-2899
FU Advancing a Healthier Wisconsin; National Institutes of Health [HL59699]
FX This work was supported by Advancing a Healthier Wisconsin; and the
   National Institutes of Health [grant number HL59699].
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NR 56
TC 74
Z9 80
U1 1
U2 10
PU PORTLAND PRESS LTD
PI LONDON
PA 1ST FLR, 10 QUEEN STREET PLACE, LONDON, ENGLAND
SN 0143-5221
EI 1470-8736
J9 CLIN SCI
JI Clin. Sci.
PD FEB
PY 2010
VL 118
IS 3-4
BP 291
EP 301
DI 10.1042/CS20090395
PG 11
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 558TA
UT WOS:000274768000015
PM 19728860
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Knight, SF
   Yuan, JH
   Roy, S
   Imig, JD
AF Knight, Sarah F.
   Yuan, Jianghe
   Roy, Siddhartha
   Imig, John D.
TI Simvastatin and tempol protect against endothelial dysfunction and renal
   injury in a model of obesity and hypertension
SO AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
LA English
DT Article
DE kidney; oxidative stress; metabolic syndrome; inflammation
ID DENSITY-LIPOPROTEIN CHOLESTEROL; OXIDATIVE STRESS; INSULIN-RESISTANCE;
   ANGIOTENSIN-II; SUPEROXIDE-DISMUTASE; ARTERIAL-PRESSURE; BLOOD-PRESSURE;
   RAT MODEL; ACID; STATINS
AB Knight SF, Yuan J, Roy S, Imig JD. Simvastatin and tempol protect against endothelial dysfunction and renal injury in a model of obesity and hypertension. Am J Physiol Renal Physiol 298: F86-F94, 2010. First published November 11, 2009; doi:10.1152/ajprenal.00351.2009.-Obesity and hypertension are risk factors for the development of chronic kidney disease. The mechanisms by which elevated blood pressure and fatty acids lead to the development of renal injury are incompletely understood. Here, we investigated the contributions of cholesterol and oxidative stress to renal endothelial dysfunction and glomerular injury in a model of obesity and hypertension. Male Wistar-Kyoto (WKY) rats and spontaneously hypertensive rats (SHR) were fed a normal diet, a high-fat diet, a high-fat diet with tempol, or a high-fat diet with simvastatin for up to 10 wk. Blood pressure was not altered by a high-fat diet or treatments. After 3 wk, renal afferent dilatory responses to acetylcholine were impaired in WKY rats and SHR fed a high-fat diet. Tempol treatment prevented this vascular dysfunction in both strains; however, simvastatin treatment demonstrated greater beneficial effects in the SHR. Albuminuria was observed in the SHR and was exacerbated by a high-fat diet. Tempol and simvastatin treatment significantly ameliorated albuminuria in the SHR fed a high-fat diet. Ten weeks on a high-fat resulted in an increase in urinary 8-isoprostane in WKY rats and SHR, and tempol and simvastatin treatment prevented this increase, indicating a reduction in renal oxidative stress. Monocyte chemoattractant protein-1 (MCP-1) excretion was significantly elevated by a high-fat diet in both strains, and tempol prevented this increase. Interestingly, simvastatin treatment had no effect on MCP-1 levels. These data indicate that tempol and simvastatin treatment via a reduction in oxidative stress improve renal endothelial function and decrease glomerular injury in a model of obesity and hypertension.
C1 [Imig, John D.] Med Coll Wisconsin, Dept Pharmacol, Milwaukee, WI 53226 USA.
   [Knight, Sarah F.; Yuan, Jianghe; Roy, Siddhartha] Med Coll Georgia, Vasc Biol Ctr, Augusta, GA 30912 USA.
C3 Medical College of Wisconsin; University System of Georgia; Augusta
   University
RP Imig, JD (corresponding author), Med Coll Wisconsin, Dept Pharmacol, Madison, WI USA.
EM jdimig@mcw.edu
OI Imig, John/0000-0002-9668-2899
FU National Institutes of Health [HL59699, DK38266]
FX This work was supported by National Institutes of Health Grants HL59699
   and DK38266.
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NR 48
TC 50
Z9 56
U1 0
U2 5
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 1931-857X
EI 1522-1466
J9 AM J PHYSIOL-RENAL
JI Am. J. Physiol.-Renal Physiol.
PD JAN
PY 2010
VL 298
IS 1
BP F86
EP F94
DI 10.1152/ajprenal.00351.2009
PG 9
WC Physiology; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology; Urology & Nephrology
GA 534VC
UT WOS:000272924500011
PM 19906952
OA Green Published
DA 2025-06-11
ER

PT J
AU Aoki, T
   Fukuda, K
   Tanaka, C
   Kamikawa, Y
   Tsuji, N
   Kasanami, R
   Hara, T
   Miyazaki, R
   Tanaka, H
   Asai, H
   Yamamoto, N
   Oishi, K
   Ishii, K
AF Aoki, Takumi
   Fukuda, Kazuhiko
   Tanaka, Chiaki
   Kamikawa, Yasuko
   Tsuji, Nobuhiro
   Kasanami, Ryoji
   Hara, Taketaka
   Miyazaki, Ryo
   Tanaka, Hideki
   Asai, Hidenori
   Yamamoto, Naofumi
   Oishi, Kan
   Ishii, Kojiro
TI The relationship between sleep habits, lifestyle factors, and achieving
   guideline-recommended physical activity levels in
   ten-to-fourteen-year-old Japanese children: A cross-sectional study
SO PLOS ONE
LA English
DT Article
ID SCHOOL-AGED CHILDREN; DAYTIME SLEEPINESS; SOCIAL JETLAG; WEIGHT STATUS;
   DURATION; ADOLESCENTS; CHRONOTYPE; DEPRESSION; VERSION; SCALE
AB The current focus of meeting the physical activity guidelines for children and young people include preventing conditions such as high blood cholesterol, high blood pressure, metabolic syndrome, obesity, low bone density, depression, and injuries. However, the relationship between sleep habits and meeting physical activity guidelines is still unclear. This study aimed to assess this relationship among fifth- to eighth-grade (ages 10-14) Japanese children. This cross-sectional study included 3,123 children (boys: 1,558, girls: 1,565, mean age: 12.5 +/- 1.2 years). Questionnaires were used to assess parameters such as moderate-to-vigorous physical activity per day, school and weekend night sleep durations, social jetlag, daytime sleepiness, napping, screen time, and breakfast intake. Participants were divided into an achievement and a non-achievement group depending on their physical activity guideline achievement status (i.e., whether they met the children's physical activity guideline of 60 min or more of moderate-to-vigorous physical activity per day). Then, to determine the sleep habits in relation to the children's achievement of guideline-recommended physical activity levels, multivariate logistic regression analyses were conducted. In fifth- and sixth-grade (ages 10-12) boys, an inverse association was observed between physical activity guideline achievement and daytime sleepiness. In seventh- and eighth-grade (ages 12-14) boys, physical activity guideline achievement was inversely associated with social jetlag and skipping breakfast. Additionally, in seventh- and eighth-grade girls, physical activity guideline achievement was inversely associated with inappropriate sleep duration on weekends and screen time. These results suggest that meeting the physical activity guideline is related to favorable sleep habits in Japanese children. However, their relevance may differ by school type and gender.
C1 [Aoki, Takumi; Oishi, Kan] Doshisha Univ, Grad Sch Hlth & Sports Sci, Kyoto, Japan.
   [Aoki, Takumi] Japan Soc Promot Sci, Tokyo, Japan.
   [Fukuda, Kazuhiko] Edogawa Univ, Coll Sociol, Chiba, Japan.
   [Tanaka, Chiaki] JF Oberlin Univ, Coll Hlth & Welf, Tokyo, Japan.
   [Kamikawa, Yasuko] Toyama Univ, Toyama, Japan.
   [Tsuji, Nobuhiro] Shiga Univ, Grad Sch Educ, Hikone, Shiga, Japan.
   [Kasanami, Ryoji] Nara Univ Educ, Fac Educ, Nara, Japan.
   [Hara, Taketaka] Shimane Univ, Fac Educ, Matsue, Shimane, Japan.
   [Miyazaki, Ryo] Shimane Univ, Fac Human Sci, Matsue, Shimane, Japan.
   [Tanaka, Hideki] Hiroshima Int Univ, Fac Psychol, Hiroshima, Japan.
   [Asai, Hidenori; Yamamoto, Naofumi] Ehime Univ, Fac Collaborat Reg Innovat, Matsuyama, Ehime, Japan.
   [Ishii, Kojiro] Doshisha Univ, Fac Hlth & Sports Sci, Kyoto, Japan.
C3 Doshisha University; Japan Society for the Promotion of Science;
   University of Toyama; Shiga University; Nara University Education;
   Shimane University; Shimane University; Ehime University; Doshisha
   University
RP Aoki, T (corresponding author), Doshisha Univ, Grad Sch Hlth & Sports Sci, Kyoto, Japan.; Aoki, T (corresponding author), Japan Soc Promot Sci, Tokyo, Japan.
EM cyhb0001@mail4.doshisha.ac.jp
RI Fukuda, Kazuhiko/ABB-3207-2021; Tanaka, Chiaki/AGN-2367-2022; Miyazaki,
   Ryo/GRR-8001-2022
OI Aoki, Takumi/0000-0002-8587-8650; Miyazaki, Ryo/0000-0002-1996-709X;
   Oishi, Kan/0000-0001-5334-9730
FU Japan Society for the Promotion of Science [JP18J11552, JP18H01000]
FX This study was financially supported by Grant-in-Aid for Scientific
   Research from the Japan Society for the Promotion of Science
   (https://www.jsps.go.jp/) (JP18J11552 to TA, JP18H01000 to KI). The
   funders had no role in study design, data collection and analysis,
   decision to publish, or preparation of the manuscript.
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NR 36
TC 9
Z9 9
U1 2
U2 15
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD NOV 13
PY 2020
VL 15
IS 11
AR e0242517
DI 10.1371/journal.pone.0242517
PG 12
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Science & Technology - Other Topics
GA OY0NB
UT WOS:000593949800054
PM 33186410
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Lemay, V
   Caru, M
   Samoilenko, M
   Drouin, S
   Alos, N
   Lefebvre, G
   Levy, E
   Lippé, S
   Marcil, V
   Sultan, S
   Bertout, L
   Krajinovic, M
   Laverdière, C
   Raboisson, MJ
   Sinnett, D
   Andelfinger, G
   Curnier, D
AF Lemay, Valerie
   Caru, Maxime
   Samoilenko, Mariia
   Drouin, Simon
   Alos, Nathalie
   Lefebvre, Genevieve
   Levy, Emile
   Lippe, Sarah
   Marcil, Valerie
   Sultan, Serge
   Bertout, Laurence
   Krajinovic, Maja
   Laverdiere, Caroline
   Raboisson, Marie-Josee
   Sinnett, Daniel
   Andelfinger, Gregor
   Curnier, Daniel
TI Prevention of Long-term Adverse Health Outcomes With Cardiorespiratory
   Fitness and Physical Activity in Childhood Acute Lymphoblastic Leukemia
   Survivors
SO JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY
LA English
DT Article
DE Childhood leukemia; physical activity; cardiorespiratory fitness;
   survivorship; preventive fraction
ID BONE-MINERAL DENSITY; VENTRICULAR DIASTOLIC FUNCTION; HOMEOSTASIS MODEL
   ASSESSMENT; INSULIN-RESISTANCE; ADULT SURVIVORS; EUROPEAN-ASSOCIATION;
   CARDIOVASCULAR RISK; METABOLIC SYNDROME; CANCER SURVIVORS;
   AMERICAN-SOCIETY
AB Background: Most childhood acute lymphoblastic leukemia (ALL) survivors develop chronic treatment-related adverse effects several years after the end of therapy. A regular practice of physical activity and a good cardiorespiratory fitness have the potential to reduce the risk of chronic disease and improve quality of life. The aim of this study was to evaluate in a cohort of ALL survivors, the association between a good cardiorespiratory fitness or the respect of physical activity guidelines and major long-term health outcomes. Methods: In total, 247 ALL survivors underwent a cardiopulmonary exercise test, completed a physical activity questionnaire and a battery of clinical examinations. We calculated the odds ratio to obtain the preventive fraction (PF) to evaluate the effects of the cardiorespiratory fitness and physical activity levels on health outcomes (ie, obesity, metabolic health, cardiac health, cognitive health and mood, bone health). Results: Despite their young age, 88% of the participants presented at least one adverse health outcome, and 46% presented >= 3. Their cardiorespiratory fitness was also lower than expected with a median VO2 peak reaching 84% of the predicted value. In the analyses using cardiorespiratory fitness, statistically significant PFs were observed for obesity (0.30), low-high-density lipoprotein-cholesterol (0.21) and depression (0.26). In the physical activity level analyses, statistically significant PFs were observed for obesity, depression, and low bone mineral density, with a PF of 0.55, 0.81, and 0.60, respectively. Conclusions: Our results indicate that a good cardiorespiratory fitness and physical activity level induced a preventive action for most health outcomes studied and was associated with a lower late adverse effects prevalence in ALL survivors.
C1 [Lemay, Valerie; Caru, Maxime; Curnier, Daniel] Univ Montreal, Sch Kinesiol & Phys Act Sci, Fac Med, Lab Pathophysiol EXercise LPEX, Montreal, PQ, Canada.
   [Lemay, Valerie; Caru, Maxime; Samoilenko, Mariia; Drouin, Simon; Alos, Nathalie; Levy, Emile; Lippe, Sarah; Marcil, Valerie; Sultan, Serge; Bertout, Laurence; Krajinovic, Maja; Laverdiere, Caroline; Raboisson, Marie-Josee; Sinnett, Daniel; Andelfinger, Gregor; Curnier, Daniel] St Justine Univ Hosp Res Ctr, Montreal, PQ, Canada.
   [Samoilenko, Mariia; Lefebvre, Genevieve] Univ Quebec, Dept Math, Montreal, PQ, Canada.
   [Alos, Nathalie; Krajinovic, Maja; Laverdiere, Caroline; Raboisson, Marie-Josee; Sinnett, Daniel; Andelfinger, Gregor] Univ Montreal, Dept Pediat, Montreal, PQ, Canada.
   [Levy, Emile; Marcil, Valerie] Univ Montreal, Dept Nutr, Montreal, PQ, Canada.
   [Krajinovic, Maja] Univ Montreal, Dept Pharmacol, Montreal, PQ, Canada.
   [Sultan, Serge] Univ Montreal, Dept Psychol, Montreal, PQ, Canada.
   [Caru, Maxime] Univ Paris Nanterre, Dept Psychol, Lab EA 4430 Clin Psychanal Dev CliPsyD, Nanterre, France.
C3 Universite de Montreal; University of Quebec; University of Quebec
   Montreal; Universite de Montreal; Universite de Montreal; Universite de
   Montreal; Universite de Montreal
RP Curnier, D (corresponding author), Univ Montreal, Dept Kinesiol, Lab Physiopathol EXercice LPEX, CEPSUM, 2100 Blvd Edouard Montpetit, Montreal, PQ H3C 3J7, Canada.
EM daniel.curnier@umontreal.ca
RI sinnett, daniel/S-4589-2017
OI Drouin, Simon/0000-0003-1686-544X; Caru, Maxime/0000-0003-2904-9185
FU Institute of Cancer Research (ICR) of the Canadian Institutes of Health
   Research (CIHR); C17 Council; Canadian Cancer Society (CCS); Cancer
   Research Society (CRS); Garron Family Cancer Centre at the Hospital for
   Sick Children; Ontario Institute for Cancer Research (OICR); Pediatric
   Oncology Group of Ontario (POGO) [TCF 118694]; Cole Foundation; Fonds de
   Recherche du Quebec-Sante (FRQS); Sainte-Justine University Hospital
   Center Foundation; Foundation of Stars
FX This work was supported by the Institute of Cancer Research (ICR) of the
   Canadian Institutes of Health Research (CIHR), in collaboration with C17
   Council, Canadian Cancer Society (CCS), Cancer Research Society (CRS),
   Garron Family Cancer Centre at the Hospital for Sick Children, Ontario
   Institute for Cancer Research (OICR), and Pediatric Oncology Group of
   Ontario (POGO) (grant number: TCF 118694). This research was also
   supported in part by PhD study grants from Cole Foundation, Fonds de
   Recherche du Quebec-Sante (FRQS), Sainte-Justine University Hospital
   Center Foundation and Foundation of Stars.
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NR 87
TC 39
Z9 40
U1 1
U2 24
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1077-4114
EI 1536-3678
J9 J PEDIAT HEMATOL ONC
JI J. Pediatr. Hematol. Oncol.
PD OCT
PY 2019
VL 41
IS 7
BP E450
EP E458
DI 10.1097/MPH.0000000000001426
PG 9
WC Oncology; Hematology; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Oncology; Hematology; Pediatrics
GA JC9YZ
UT WOS:000489633800007
PM 30688830
DA 2025-06-11
ER

PT J
AU Yang, K
   Wu, Y
   Chen, DD
   Liu, SM
   Chen, RC
AF Yang, Kai
   Wu, Ying
   Chen, Dandan
   Liu, Shengming
   Chen, Rongchang
TI The Impact of Lung Function on Extra-Pulmonary Diseases and All-Cause
   Mortality in US Adult Population with and without COPD
SO CLINICAL EPIDEMIOLOGY
LA English
DT Article
DE lung function; mortality; extra-pulmonary diseases; COPD
ID NATIONAL-HEALTH; COMORBIDITIES; DEPRESSION; PREVALENCE; MANAGEMENT;
   SMOKING; OBESITY; BURDEN
AB Objective: Spirometric lung function is usually used to evaluate respiratory health. However, the impact of lung function on extra-pulmonary diseases and all-cause mortality has not been fully elucidated, especially in people without chronic obstructive pulmonary disease (COPD).
   Patients and Methods: Participants aged >= 20 and underwent spirometry test from the US National Health and Nutrition Examination Surveys (NHANES) 2007-2012 were analyzed in this study. Multivariate logistic and Cox regressions were used to evaluate the impact of forced expiratory volume in 1 second percent of predicted (FEV1% predicted) and forced vital capacity percent of predicted (FVC% predicted) on 14 extra-pulmonary diseases and all-cause morbidity after adjusting for multiple confounders.
   Results: During 2007-2012, 1800 COPD patients and 11,437 non-COPD subjects were included. The prevalence of hypertension, diabetes mellitus (DM), dyslipidemia, metabolic syndrome (MS), congestive heart failure (CHF), coronary disease, stroke, chronic kidney disease (CKD), arthritis, cancer, underweight and osteoporosis in COPD patients was higher than that in the non-COPD population. After adjusting for confounders, the decrease of FEV1% predicted and FVC% predicted was related with higher odds of having hypertension, DM, obesity, MS, CHF, coronary disease and depression (OR > 1, P<0.05) in both the COPD and non-COPD populations. These 2 indices were also related with higher odds of dyslipidemia, CKD, arthritis and osteoporosis in the non-COPD population. The risk of stroke, anemia and cancer was not related with the decrease of lung function. In addition, the decrease of lung function was independent risk factors for the increase of all-cause mortality. These risks were gradually increased with the decrease of lung function.
   Conclusion: The decrease of FEV1% predicted and FVC% predicted was related with higher risk of multiple extra-pulmonary diseases and all-cause mortality in both the COPD and non-COPD population.
C1 [Yang, Kai; Chen, Dandan; Chen, Rongchang] Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen Inst Resp Dis, Shenzhen Peoples Hosp,Clin Med Coll 2,Jinan Univ, Shenzhen 518055, Guangdong, Peoples R China.
   [Wu, Ying] Southern Med Univ, Sch Publ Hlth, Dept Biostat, Guangzhou, Guangdong, Peoples R China.
   [Liu, Shengming] Jinan Univ, Affiliated Hosp 1, Dept Resp Med, Guangzhou 510000, Guangdong, Peoples R China.
C3 Jinan University; Southern University of Science & Technology; Southern
   Medical University - China; Jinan University
RP Chen, RC (corresponding author), Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen Inst Resp Dis, Shenzhen Peoples Hosp,Clin Med Coll 2,Jinan Univ, Shenzhen 518055, Guangdong, Peoples R China.; Liu, SM (corresponding author), Jinan Univ, Affiliated Hosp 1, Dept Resp Med, Guangzhou 510000, Guangdong, Peoples R China.
EM tlsm@jnu.edu.cn; chenrc@vip.163.com
RI Yang, Kai/KFS-3272-2024
OI Yang, Kai/0000-0002-1982-4398
FU National Natural Science Foundation of China [81703322]
FX This study was supported by the National Natural Science Foundation of
   China (Grant number: 81703322).
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NR 36
TC 17
Z9 19
U1 1
U2 11
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1179-1349
J9 CLIN EPIDEMIOL
JI Clin. Epidemiol.
PY 2020
VL 12
BP 997
EP 1005
DI 10.2147/CLEP.S270599
PG 9
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA NW6FG
UT WOS:000575109400001
PM 33061647
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Touati, S
   Montezano, ACI
   Meziri, F
   Riva, C
   Touyz, RM
   Laurant, P
AF Touati, Sabeur
   Montezano, Augusto C. I.
   Meziri, Faycal
   Riva, Catherine
   Touyz, Rhian M.
   Laurant, Pascal
TI Exercise training protects against atherosclerotic risk factors through
   vascular NADPH oxidase, extracellular signal-regulated kinase 1/2 and
   stress-activated protein kinase/c-Jun N-terminal kinase downregulation
   in obese rats
SO CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
LA English
DT Article
DE exercise; inflammation; NADPH oxidase; obesity; oxidative stress
ID CORONARY-ARTERY-DISEASE; OXIDATIVE STRESS; NAD(P)H OXIDASE;
   INSULIN-RESISTANCE; ANGIOTENSIN-II; CARDIOVASCULAR-DISEASE;
   PHYSICAL-ACTIVITY; ENDOTHELIAL DYSFUNCTION; SUPEROXIDE-PRODUCTION;
   SHEAR-STRESS
AB Exercise training reverses atherosclerotic risk factors associated with metabolic syndrome and obesity. The aim of the present study was to determine the molecular anti-inflammatory, anti-oxidative and anti-atherogenic effects in aorta from rats with high-fat diet-induced obesity. Male Sprague-Dawley rats were placed on a high-fat (HFD) or control (CD) diet for 12weeks. The HFD rats were then divided into four groups: (i) sedentary HFD-fed rats (HFD-S); (ii) exercise trained (motor treadmill 5days/week, 60min/day, 12weeks) HFD-fed rats (HFD-Ex); (iii) modified diet (HFD to CD) sedentary rats (HF/CD-S); and (iv) an exercise-trained modified diet group (HF/CD-Ex). Tissue levels of NADPH oxidase (activity and expression), NADPH oxidase (Nox) 1, Nox2, Nox4, p47(phox), superoxide dismutase (SOD)-1, angiotensin AT(1) and AT(2) receptors, phosphorylated mitogen-activated protein kinase (MAPK; extracellular signal-regulated kinase (ERK) 1/2, stress-activated protein kinase (SAPK)/c-Jun N-terminal kinase (JNK)) and vascular cell adhesion molecule-1 (VCAM-1) were determined in the aorta. Plasma cytokines (tumour necrosis factor (TNF)- and interleukin (IL)-6) levels were also measured. Obesity was accompanied by increases in NADPH oxidase activity, p47(phox) translocation, Nox4 and VCAM-1 protein expression, MAPK (ERK1/2, SAPK/JNK) phosphorylation and plasma TNF- and IL-6 levels. Exercise training and switching from the HFD to CD reversed almost all these molecular changes. In addition, training increased aortic SOD-1 protein expression and decreased ERK1/2 phosphorylation. These findings suggest that protective effects of exercise training on atherosclerotic risk factors induced by obesity are associated with downregulation of NADPH oxidase, ERK1/2 and SAPK/JNK activity and increased SOD-1 expression.
C1 [Touati, Sabeur; Meziri, Faycal; Riva, Catherine; Laurant, Pascal] Avignon Univ, Lab Cardiovasc Pharm Ecol LAPEC EA4278, Avignon, France.
   [Touati, Sabeur; Montezano, Augusto C. I.; Meziri, Faycal; Touyz, Rhian M.] Univ Ottawa, Ottawa Hlth Res Inst, Kidney Res Ctr, Ottawa, ON, Canada.
C3 Avignon Universite; University of Ottawa; Ottawa Hospital Research
   Institute
RP Laurant, P (corresponding author), Fac Sci, Lab Pharm Ecol Cardiovasc EA4278, 15 Blvd Limbert, F-84000 Avignon, France.
EM pascal.laurant@univ-avignon.fr
RI Touyz, Rhian/AAM-3564-2020
OI Touyz, Rhian/0000-0003-0670-0887
FU Canadian Institutes of Health Research; Canada Research Chair of the
   Canadian Institutes of Health Research; Canadian Foundation for
   Innovation
FX This study was supported by grants from the Canadian Institutes of
   Health Research (to RMT). RMT was funded by a Canada Research Chair of
   the Canadian Institutes of Health Research and through the Canadian
   Foundation for Innovation. The authors thank Dr Ying He for excellent
   technical assistance. Results of the present study do not constitute
   endorsement by the American College of Sports Medicine.
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NR 40
TC 26
Z9 32
U1 0
U2 14
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1440-1681
J9 CLIN EXP PHARMACOL P
JI Clin. Exp. Pharmacol. Physiol.
PD FEB
PY 2015
VL 42
IS 2
BP 179
EP 185
DI 10.1111/1440-1681.12338
PG 7
WC Pharmacology & Pharmacy; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Physiology
GA AY8PE
UT WOS:000347814900008
PM 25399833
DA 2025-06-11
ER

PT J
AU Torres-Torres, J
   Monroy-Muñoz, IE
   Perez-Duran, J
   Solis-Paredes, JM
   Camacho-Martinez, ZA
   Baca, D
   Espino-y-Sosa, S
   Martinez-Portilla, R
   Rojas-Zepeda, L
   Borboa-Olivares, H
   Reyes-Muñoz, E
AF Torres-Torres, Johnatan
   Monroy-Munoz, Irma Eloisa
   Perez-Duran, Javier
   Solis-Paredes, Juan Mario
   Camacho-Martinez, Zaira Alexi
   Baca, Deyanira
   Espino-y-Sosa, Salvador
   Martinez-Portilla, Raigam
   Rojas-Zepeda, Lourdes
   Borboa-Olivares, Hector
   Reyes-Munoz, Enrique
TI Cellular and Molecular Pathophysiology of Gestational Diabetes
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE gestational diabetes; insulin resistance; mitochondrial dysfunction;
   oxidative stress; chronic inflammation; placental dysfunction
ID INSULIN-RECEPTOR SUBSTRATE-1; CHAIN FATTY-ACIDS; GUT MICROBIOTA; SERINE
   PHOSPHORYLATION; OXIDATIVE STRESS; RESISTANCE; MELLITUS; FERROPTOSIS;
   PREGNANCY; TARGET
AB Gestational diabetes (GD) is a metabolic disorder characterized by glucose intolerance during pregnancy, significantly impacting maternal and fetal health. Its global prevalence is approximately 14%, with risk factors including obesity, family history of diabetes, advanced maternal age, and ethnicity, which are linked to cellular and molecular disruptions in glucose regulation and insulin resistance. GD is associated with short- and long-term complications for both the mother and the newborn. For mothers, GD increases the risk of developing type 2 diabetes, cardiovascular diseases, and metabolic syndrome. In the offspring, exposure to GD in utero predisposes them to obesity, glucose intolerance, and metabolic disorders later in life. This review aims to elucidate the complex cellular and molecular mechanisms underlying GD to inform the development of effective therapeutic strategies. A systematic review was conducted using medical subject headings (MeSH) terms related to GD's cellular and molecular pathophysiology. Inclusion criteria encompassed original studies, systematic reviews, and meta-analyses focusing on GD's impact on maternal and fetal health, adhering to PRISMA guidelines. Data extraction captured study characteristics, maternal and fetal outcomes, key findings, and conclusions. GD disrupts insulin signaling pathways, leading to impaired glucose uptake and insulin resistance. Mitochondrial dysfunction reduces ATP production and increases reactive oxygen species, exacerbating oxidative stress. Hormonal influences, chronic inflammation, and dysregulation of the mammalian target of rapamycin (mTOR) pathway further impair insulin signaling. Gut microbiota alterations, gene expression, and epigenetic modifications play significant roles in GD. Ferroptosis and placental dysfunction primarily contribute to intrauterine growth restriction. Conversely, fetal macrosomia arises from maternal hyperglycemia and subsequent fetal hyperinsulinemia, resulting in excessive fetal growth. The chronic inflammatory state and oxidative stress associated with GD exacerbate these complications, creating a hostile intrauterine environment. GD's complex pathophysiology involves multiple disruptions in insulin signaling, mitochondrial function, inflammation, and oxidative stress. Effective management requires early detection, preventive strategies, and international collaboration to standardize care and improve outcomes for mothers and babies.
C1 [Torres-Torres, Johnatan; Monroy-Munoz, Irma Eloisa; Perez-Duran, Javier; Solis-Paredes, Juan Mario; Espino-y-Sosa, Salvador; Martinez-Portilla, Raigam] Inst Nacl Perinatol Isidro Espinosa Reyes, Dept Reprod & Perinatal Hlth Res, Mexico City 11000, Mexico.
   [Torres-Torres, Johnatan; Camacho-Martinez, Zaira Alexi; Baca, Deyanira] Hosp Gen Mexico Dr Eduardo Liceaga, Obstet & Gynecol Dept, Mexico City 06720, Mexico.
   [Espino-y-Sosa, Salvador] Univ Anahuac Mexico, Ctr Invest Ciencias Salud, Campus Norte, Huixquilucan 52786, Mexico.
   [Rojas-Zepeda, Lourdes] Inst Materno Infantil Estado Mexico, Maternal Fetal Med Dept, Toluca 50170, Mexico.
   [Borboa-Olivares, Hector] Inst Nacl Perinatol Isidro Espinosa Reyes, Community Intervent Res Branch, Mexico City 11000, Mexico.
   [Reyes-Munoz, Enrique] Inst Nacl Perinatol Isidro Espinosa Reyes, Res Div, Mexico City 11000, Mexico.
C3 Universidad Anahuac
RP Torres-Torres, J (corresponding author), Inst Nacl Perinatol Isidro Espinosa Reyes, Dept Reprod & Perinatal Hlth Res, Mexico City 11000, Mexico.; Torres-Torres, J (corresponding author), Hosp Gen Mexico Dr Eduardo Liceaga, Obstet & Gynecol Dept, Mexico City 06720, Mexico.
EM torresmmf@gmail.com
RI Espino, Salvador/ABE-5440-2021; Reyes-Muñoz, Enrique/U-9134-2019;
   Martinez Portilla, Raigam Jafet/S-7980-2016
OI Solis Paredes, Juan Mario/0000-0003-4529-8296; Martinez Portilla, Raigam
   Jafet/0000-0003-4711-3857; Reyes-Munoz, Enrique/0000-0001-5304-7476;
   Perez Duran, Javier/0000-0003-3302-7720; Espino y Sosa,
   Salvador/0000-0001-7276-8463; Monroy-Munoz, Irma
   Eloisa/0000-0001-8737-8935; Torres, Johnatan/0000-0002-9524-4133
FU Instituto Nacional de Perinatologia Isidro Espinosa de los Reyes
FX We would like to extend our sincere gratitude to the Instituto Nacional
   de Perinatologia Isidro Espinosa de los Reyes for their financial
   support, which covered the publication charges for this study. Their
   generous contribution has been invaluable in facilitating the
   dissemination of our research findings.
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NR 99
TC 7
Z9 7
U1 8
U2 8
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD NOV
PY 2024
VL 25
IS 21
AR 11641
DI 10.3390/ijms252111641
PG 25
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA L5K8L
UT WOS:001351115000001
PM 39519193
OA gold
DA 2025-06-11
ER

PT J
AU Machi, JF
   Dias, DD
   Freitas, SC
   de Moraes, OA
   da Silva, MB
   Cruz, PL
   Mostarda, C
   Salemi, VMC
   Morris, M
   De Angelis, K
   Irigoyen, MC
AF Machi, Jacqueline Freire
   Dias, Danielle da Silva
   Freitas, Sarah Cristina
   de Moraes, Oscar Albuquerque
   da Silva, Maikon Barbosa
   Cruz, Paula Lazara
   Mostarda, Cristiano
   Salemi, Vera M. C.
   Morris, Mariana
   De Angelis, Katia
   Irigoyen, Maria-Claudia
TI Impact of aging on cardiac function in a female rat model of menopause:
   role of autonomic control, inflammation, and oxidative stress
SO CLINICAL INTERVENTIONS IN AGING
LA English
DT Article
DE autonomic nervous system; aging; aerobic exercise; female rats
ID HEART-RATE; METABOLIC SYNDROME; EXERCISE; DYSFUNCTION; OBESITY;
   HYPERTENSION; EXPRESSION; INCREASES; BENEFITS; SYNTHASE
AB Objective: The aim of this study was to evaluate the effects of aging on metabolic, cardiovascular, autonomic, inflammatory, and oxidative stress parameters after ovarian hormone deprivation (OVX).
   Methods: Female Wistar rats (3 or 22 months old) were divided into: young controls, young ovariectomized, old controls, and old ovariectomized (bilateral ovaries removal). After a 9-week follow-up, physical capacity, metabolic parameters, and morphometric and cardiac functions were assessed. Subsequently, arterial pressure was recorded and cardiac autonomic control was evaluated. Oxidative stress was measured on the cardiac tissue, while inflammatory profile was assessed in the plasma.
   Results: Aging or OVX caused an increase in body and fat weight and triglyceride concentration and a decrease in both insulin sensitivity and aerobic exercise capacity. Left ventricular diastolic dysfunction and increased cardiac overload (myocardial performance index) were reported in old groups when compared with young groups. Aging and OVX led to an increased sympathetic tonus, and vagal tonus was lower only for the old groups. Tumor necrosis factor-a and interleukin-6 were increased in old groups when compared with young groups. Glutathione redox balance (GSH/GSSG) was reduced in young ovariectomized, old controls, and old ovariectomized groups when compared with young controls, indicating an increased oxidative stress. A negative correlation was found between GSH/GSSG and tumor necrosis factor-a (r=-0.6, P<0.003). Correlations were found between interleukin-6 with adipose tissue (r=0.5, P<0.009) and vagal tonus (r=-0.7, P<0.0002); and among myocardial performance index with interleukin-6 (r=0.65, P<0.0002), sympathetic tonus (r=0.55, P<0.006), and physical capacity (r=-0.55, P<0.003). The findings in this trial showed that ovariectomy aggravated the impairment of cardiac and functional effects of aging in female rats, probably associated with exacerbated autonomic dysfunction, inflammation, and oxidative stress.
C1 [Machi, Jacqueline Freire; de Moraes, Oscar Albuquerque; da Silva, Maikon Barbosa; Cruz, Paula Lazara; Salemi, Vera M. C.; Irigoyen, Maria-Claudia] Univ Sao Paulo, Sch Med, Hypertens Unit, Heart Inst InCor, Ave Dr Eneas de Carvalho Aguiar 44, BR-05403900 Sao Paulo, SP, Brazil.
   [Machi, Jacqueline Freire; Morris, Mariana] Nova SE Univ, Inst Neuroimmune Med, Ft Lauderdale, FL 33314 USA.
   [Dias, Danielle da Silva; Freitas, Sarah Cristina; De Angelis, Katia] Univ Nove Julho UNINOVE, Lab Translat Physiol, Sao Paulo, Brazil.
   [Mostarda, Cristiano] Fed Univ Maranhao UFMA, Hlth Adult & Child, Sao Luiz Maranhao, Brazil.
C3 Universidade de Sao Paulo; Nova Southeastern University; Universidade
   Nove de Julho; Universidade Federal do Maranhao
RP Irigoyen, MC (corresponding author), Univ Sao Paulo, Sch Med, Hypertens Unit, Heart Inst InCor, Ave Dr Eneas de Carvalho Aguiar 44, BR-05403900 Sao Paulo, SP, Brazil.
EM hipirigoyen@incor.usp.br
RI Salemi, Vera/AAY-5024-2020; Mostarda, Cristiano/AAG-4087-2019; da Silva
   Dias, Danielle/AAN-7618-2020; Irigoyen, maria Claudia/N-6880-2014; DE
   ANGELIS, KATIA/I-6098-2016; Freitas, Sarah/Y-1938-2018; Salemi,
   Vera/C-9104-2013
OI Irigoyen, maria Claudia/0000-0003-2097-3662; Cruz, Paula
   Lazara/0000-0001-9917-9570; Mostarda, Cristiano
   Teixeira/0000-0002-1305-1697; DE ANGELIS, KATIA/0000-0002-3640-9049;
   Freitas, Sarah/0000-0003-2802-8753; Salemi, Vera/0000-0002-7152-1810
FU CNPq [563961/2010, 484713/2011, 306 011/2010, 457200/2014-6,
   309292/2014-0]; CAPES [PVE-074/12, 88881.062178/2014-01]; FAPESP
   [2012/20141-5]
FX This study was supported by CNPq (563961/2010- MCI, KA; 484713/2011-
   MCI, KA; 306 011/2010-MCI; 457200/2014-6; 309292/2014-0 KA); CAPES
   (PVE-074/12-JFM, KA, MM, MCI; 88881.062178/2014-01 KA), and FAPESP
   2012/20141-5 KA.
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NR 42
TC 39
Z9 44
U1 0
U2 11
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
EI 1178-1998
J9 CLIN INTERV AGING
JI Clin. Interv. Aging
PY 2016
VL 11
BP 341
EP 350
DI 10.2147/CIA.S88441
PG 10
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA DH0VH
UT WOS:000372501700001
PM 27042032
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Aydemir, D
   Aydogan-Ahbab, M
   Barlas, N
   Ulusu, NN
AF Aydemir, Duygu
   Aydogan-Ahbab, Mufide
   Barlas, Nurhayat
   Ulusu, Nuriye Nuray
TI Effects of the in-utero dicyclohexyl phthalate and
   di-n-hexyl phthalate administration on the oxidative
   stress-induced histopathological changes in the rat liver tissue
   correlated with serum biochemistry and hematological parameters
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Article
DE DHP; DCHP; phthalates; oxidative stress; liver; biochemistry
ID SUBCHRONIC EXPOSURE; METABOLITES; BUTYLPARABEN; BIOMARKERS; PLACENTA;
   RECEPTOR; KIDNEY; ALPHA
AB Phthalates are widely used as plasticizers in the industry and are found in cosmetics, food and drink packaging, drugs, toys, households, medical devices, pesticides, personal care products, and paints. Phthalates exert endocrine disrupting and peroxisome proliferator effects in humans and wildlife associated with the pathogenesis of various diseases, including diabetes, obesity, infertility, cardiovascular diseases, metabolic syndrome, and cancer. Since phthalates are metabolized in the liver, which regulates the body's energy metabolism, long or short-term exposure to the phthalates is associated with impaired glucose, lipid, and oxidative stress metabolisms contributing to liver toxicity. However, the impact of in-utero exposure to DHP and DCHP on liver metabolism has not been studied previously. Thus, in this study, we evaluated serum biochemistry parameters, hematological markers, histopathological changes, and oxidative and pentose phosphate pathway (PPP) metabolisms in the liver following in-utero DHP and DCHP administration, respectively, in male and female rats. We found increased relative and absolute liver weights and impaired triglyceride, alanine transaminase (ALT), lactate dehydrogenase (LDH), and alkaline phosphatase (ALP) levels upon dicyclohexyl phthalate (DCHP) and di-n-hexyl phthalate (DHP). Histopathological changes, including congestion, sinusoidal dilatation, inflammatory cell infiltration, cells with a pyknotic nucleus, lysis of hepatocytes, and degeneration of hepatic parenchyma have been observed in the liver samples of DHP and DCHP dose groups. Moreover, increased glutathione s-transferase (GST), glucose 6-phosphate dehydrogenase (G6PD), and glutathione reductase (GR) activities have been found in the liver samples of DHP and DCHP-treated rats associated with impaired pentose phosphate pathway (PPP) and oxidative stress metabolism. First time in the literature, we showed that in-utero exposure to DHP and DCHP causes liver damage associated with impaired oxidative stress metabolism in male and female rats. Our data may guide researchers and governments to regulate and restrict phthalates in industrial products.
C1 [Aydemir, Duygu; Ulusu, Nuriye Nuray] Koc Univ, Sch Med, Dept Med Biochem, Istanbul, Turkiye.
   [Aydemir, Duygu; Ulusu, Nuriye Nuray] Koc Univ, Res Ctr Translat Med KUTTAM, Istanbul, Turkiye.
   [Aydogan-Ahbab, Mufide] Univ Hlth Sci Turkey, Hamidiye Vocat Sch Hlth Serv, Istanbul, Turkiye.
   [Barlas, Nurhayat] Hacettepe Univ, Sci Fac, Dept Biol, Ankara, Turkiye.
C3 Koc University; Koc University; Hacettepe University
RP Ulusu, NN (corresponding author), Koc Univ, Sch Med, Dept Med Biochem, Istanbul, Turkiye.; Ulusu, NN (corresponding author), Koc Univ, Res Ctr Translat Med KUTTAM, Istanbul, Turkiye.
EM nulusu@ku.edu.tr
RI Aydemir, Duygu/AAT-8537-2021; Aydoğan Ahbab, Müfide/ABB-7091-2022
OI Aydemir, Duygu/0000-0002-6449-2708
FU Health Sciences Research Group of TUBITAK [105S073]
FX This research was supported by Health Sciences Research Group of TUBITAK
   (Project number is 105S073).
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NR 69
TC 5
Z9 5
U1 4
U2 26
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD MAY 19
PY 2023
VL 14
AR 1128202
DI 10.3389/fendo.2023.1128202
PG 18
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA I0EZ2
UT WOS:000999605800001
PM 37274322
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Pardo, M
   Kuperman, Y
   Levin, L
   Rudich, A
   Haim, Y
   Schauer, JJ
   Chen, A
   Rudich, Y
AF Pardo, Michal
   Kuperman, Yael
   Levin, Liron
   Rudich, Assaf
   Haim, Yulia
   Schauer, James J.
   Chen, Alon
   Rudich, Yinon
TI Exposure to air pollution interacts with obesogenic nutrition to induce
   tissue-specific response patterns
SO ENVIRONMENTAL POLLUTION
LA English
DT Article
DE Air pollution; Obesogenic nutrition; Oxidative stress; Inflammation;
   Lungs; Nrf2 transcription factor; Methyltransferases; Intra-tracheal
   instillation
ID FINE PARTICULATE MATTER; HIGH-FAT DIET; OXIDATIVE STRESS; SIGNALING
   PATHWAY; EPIGENETIC REGULATION; GLUCOSE-HOMEOSTASIS; INSULIN
   SENSITIVITY; DEFENSE-MECHANISMS; METABOLIC SYNDROME; DNA METHYLATION
AB Obesity and exposure to particular matter (PM) have become two leading global threats to public health. However, the exact mechanisms and tissue-specificity of their health effects are largely unknown. Here we investigate whether a metabolic challenge (early nutritional obesity) synergistically interacts with an environmental challenge (PM exposure) to alter genes representing key response pathways, in a tissue specific manner. Mice subjected to 7 weeks obesogenic nutrition were exposed every other day during the final week and a half to aqueous extracts of PM collected in the city of London (UK). The expression of 61 selected genes representing key response pathways were investigated in lung, liver, white and brown adipose tissues. Principal component analysis (PCA) revealed distinct patterns of expression changes between the 4 tissues, particularly in the lungs and the liver. Surprisingly, the lung responded to the nutrition challenge. The response of these organs to the PM challenge displayed opposite patterns for some key genes, in particular, those related to the Nrf2 pathway. While the contribution to the variance in gene expression changes in mice exposed to the combined challenge were largely similar among the tissues in PCA1, PCA2 exhibited predominant contribution of inflammatory and oxidative stress responses to the variance in the lungs, and a greater contribution of autophagy genes and MAP kinases in adipose tissues. Possible involvement of alterations in DNA methylation was demonstrated by cell-type-specific responses to a methylation inhibitor. Correspondingly, the DNA methyltransferase Dnmt3a2 increased in the lungs but decreased in the liver, demonstrating potential tissue-differential synergism between nutritional and PM exposure. The results suggest that urban PM, containing dissolved metals, interacts with obesogenic nutrition to regulate diverse response pathways including inflammation and oxidative stress, in a tissue-specific manner. Tissue-differential effects on DNA methylation may underlie tissue-specific responses to key stress-response genes such as catalase and Nrf2. (C) 2018 Elsevier Ltd. All rights reserved.
C1 [Pardo, Michal; Rudich, Yinon] Weizmann Inst Sci, Dept Earth & Planetary Sci, IL-76100 Rehovot, Israel.
   [Kuperman, Yael] Weizmann Inst Sci, Dept Vet Resources, IL-76100 Rehovot, Israel.
   [Levin, Liron] Ben Gurion Univ Negev, Dept Life Sci, Bioinformat Core Facil, IL-84103 Beer Sheva, Israel.
   [Rudich, Assaf; Haim, Yulia] Ben Gurion Univ Negev, Dept Clin Biochem & Pharmacol, Fac Hlth Sci, IL-84103 Beer Sheva, Israel.
   [Rudich, Assaf; Haim, Yulia] Ben Gurion Univ Negev, Natl Inst Biotechnol Negev, IL-84103 Beer Sheva, Israel.
   [Schauer, James J.] Univ Wisconsin, Environm Chem & Technol Program, Madison, WI USA.
   [Chen, Alon] Weizmann Inst Sci, Dept Neurobiol, IL-76100 Rehovot, Israel.
   [Chen, Alon] Max Planck Inst Psychiat, Dept Stress Neurobiol & Neurogenet, Munich, Germany.
C3 Weizmann Institute of Science; Weizmann Institute of Science; Ben-Gurion
   University of the Negev; Ben-Gurion University of the Negev; Ben-Gurion
   University of the Negev; University of Wisconsin System; University of
   Wisconsin Madison; Weizmann Institute of Science; Max Planck Society
RP Pardo, M (corresponding author), Weizmann Inst Sci, Dept Earth & Planetary Sci, IL-76100 Rehovot, Israel.
EM michal.levin@weizmann.ac.il
RI Pardo, Michal/K-3006-2019; RUDICH, ASSAF/MSY-8816-2025; Rudich,
   Yinon/K-1498-2012
OI Schauer, James/0000-0002-5405-1511; Pardo, Michal/0000-0001-6480-1171;
   Rudich, Yinon/0000-0003-3149-0201; Rudich, Assaf/0000-0002-1366-1444
FU Israel Science Foundation (ISF); National Natural Science Foundation of
   China (NSFC) [2229/15]; Israel-US Binational Science Foundation (BSF)
   [20111/78]
FX Y.K. is the incumbent of the Sarah and Rolando Uziel Research Associate
   Chair. We thank Dr. Yoav Barak and Sharon Manashirov for their fruitful
   discussions. This research was partially funded by the Israel Science
   Foundation (ISF) and the National Natural Science Foundation of China
   (NSFC) grant number 2229/15. A.R. and J.J.S. collaboration was supported
   by the Israel-US Binational Science Foundation (BSF) 20111/78.
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NR 72
TC 17
Z9 17
U1 0
U2 33
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0269-7491
EI 1873-6424
J9 ENVIRON POLLUT
JI Environ. Pollut.
PD AUG
PY 2018
VL 239
BP 532
EP 543
DI 10.1016/j.envpol.2018.04.048
PG 12
WC Environmental Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology
GA GI8AS
UT WOS:000434744800055
PM 29684880
DA 2025-06-11
ER

PT J
AU Mondal, D
   Mathur, A
   Chandra, PK
AF Mondal, Debasis
   Mathur, Aditi
   Chandra, Partha K.
TI Tripping on TRIB3 at the junction of health, metabolic dysfunction and
   cancer
SO BIOCHIMIE
LA English
DT Review
DE TRIB3; Metabolic syndrome; Cancer; ER-stress; PI3K/AKT/mTOR; Autophagy
ID ENDOPLASMIC-RETICULUM STRESS; UNFOLDED PROTEIN RESPONSE; NF-KAPPA-B;
   TRIBBLES HOMOLOG 3; FUNCTIONAL Q84R POLYMORPHISM; REDUCED AKT
   PHOSPHORYLATION; TO-MESENCHYMAL TRANSITION; TRANSCRIPTION FACTOR XBP1;
   NITRIC-OXIDE PRODUCTION; PANCREATIC BETA-CELLS
AB Metabolic diseases like obesity, atherosclerosis and diabetes are frequently associated with increased risk of aggressive cancers. Although metabolic dysfunctions in normal cells are manifested due to defective signaling networks that control cellular homeostasis, malignant cells utilize these signaling networks for their increased survival, growth and metastasis. Despite decades of research, a common mechanistic link between these chronic pathologies is still not well delineated. Evidences show that the unfolded protein response (UPR) and the endoplasmic reticulum stress (ERS) pathways are often dysregulated in both metabolic diseases and cancer. The UPR also triggers coordinated signaling with both PI3K/AKT/mTOR and Autophagy pathways in order to promote stress-adaptive mechanisms. Whereas, uncontrolled UPR and the resultant ERS escalates cells towards metabolic dysfunctions and ultimately cell death. In this review, we will discuss findings that implicate a crucial role for the multifunctional ERS-induced protein, TRIB3. The 'pseudokinase' function of TRIB3 facilitates the inactivation of multiple transcription factors and signaling proteins. The MEK1 binding domain of TRIB3 enables it to deactivate multiple MAP-kinases. In addition, the COP1 motif of TRIB3 assists ubiquitination and proteasomal degradation of numerous TRIB3 associated proteins. The most well studied action of TRIB3 has been on the PI3K/AKT/mTOR pathway, where TRIB3-mediated inhibition of AKT phosphorylation decreases insulin signaling and cell survival. Conversely, cancer cells can either upregulate the ART survival pathway by suppressing TRIB3 expression or alter TRIB3 localization to degrade differentiation inducing nuclear transcription factors such as C/EBP alpha and PPAR gamma. The gain-of-function Q84R polymorphism in TRIB3 is associated with increased risk of diabetes and atherosclerosis. TRIB3 acts as a crucial 'stress adjusting switch' that links homeostasis, metabolic disease and cancer; and is being actively investigated as a disease biomarker and therapeutic target. (C) 2016 Elsevier B.V. and Societe Francaise de Biochimie et Biologie Moleculaire (SFBBM). All rights reserved.
C1 [Mondal, Debasis; Mathur, Aditi; Chandra, Partha K.] Tulane Univ, Sch Med, Dept Pharmacol, 1430 Tulane Ave, New Orleans, LA 70112 USA.
C3 Tulane University
RP Mondal, D (corresponding author), Tulane Univ, Sch Med, Dept Pharmacol, 1430 Tulane Ave, New Orleans, LA 70112 USA.
EM dmondal@tulane.edu
RI MATHUR, ADITI/KFQ-7217-2024
OI Mathur, Aditi/0009-0008-3870-8254
FU Department of Defense [PC080811]; Louisiana Cancer Research Consortium
   (LCRC)
FX This work was supported by grants from the Department of Defense
   (#PC080811) and funds from the Louisiana Cancer Research Consortium
   (LCRC) to DM.
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NR 261
TC 49
Z9 62
U1 0
U2 24
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0300-9084
EI 1638-6183
J9 BIOCHIMIE
JI Biochimie
PD MAY
PY 2016
VL 124
BP 34
EP 52
DI 10.1016/j.biochi.2016.02.005
PG 19
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA DK4UZ
UT WOS:000374917100006
PM 26855171
OA Bronze
DA 2025-06-11
ER

PT J
AU Murphy, MO
   Herald, JB
   Wills, CT
   Unfried, SG
   Cohn, DM
   Loria, AS
AF Murphy, Margaret O.
   Herald, Joseph B.
   Wills, Caleb T.
   Unfried, Stanley G.
   Cohn, Dianne M.
   Loria, Analia S.
TI Postnatal treatment with metyrapone attenuates the effects of
   diet-induced obesity in female rats exposed to early-life stress
SO AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
LA English
DT Article
DE early-life stress; high fat diet; maternal separation; metyrapone; sex
   differences in developmental programming of metabolic disease
ID ADVERSE CHILDHOOD EXPERIENCES; MATERNAL SEPARATION; METABOLIC SYNDROME;
   SEX-DIFFERENCES; ADIPOSE-TISSUE; CARDIOVASCULAR-DISEASE; HYPORESPONSIVE
   PERIOD; RECEPTOR EXPRESSION; NEUROPEPTIDE-Y; BLOOD-PRESSURE
AB Experimental studies in rodents have shown that females are more susceptible to exhibiting fat expansion and metabolic disease compared with males in several models of fetal programming. This study tested the hypothesis that female rat pups exposed to maternal separation (MatSep), a model of early-life stress, display an exacerbated response to dietinduced obesity compared with male rats. Also, we tested whether the postnatal treatment with metyrapone (MTP), a corticosterone synthase inhibitor, would attenuate this phenotype. MatSep was performed in WKY offspring by separation from the dam (3 h/day, postnatal days 2-14). Upon weaning, male and female rats were placed on a normal (ND; 18% kcal fat) or high-fat diet (HFD; 60% kcal fat). Non-disturbed littermates served as controls. In male rats, no diet-induced differences in body weight (BW), glucose tolerance, and fat tissue weight and morphology were found between MatSep and control male rats. However, female MatSep rats displayed increased BW gain, fat pad weights, and glucose intolerance compared with control rats (P < 0.05). Also, HFD increased plasma corticosterone (196 +/- 51 vs. 79 +/- 18 pg/ml, P < 0.05) and leptin levels (1.8 +/- 0.4 vs. 1.3 +/- 0.1 ng/ml, P < 0.05) in female MatSep compared with control rats, whereas insulin and adiponectin levels were similar between groups. Female control and MatSep offspring were treated with MTP (50 mu g/g ip) 30 min before the daily separation. MTP treatment significantly attenuated diet-induced obesity risk factors, including elevated adiposity, hyperleptinemia, and glucose intolerance. These findings show that exposure to stress hormones during early life could be a key event to enhance diet-induced obesity and metabolic disease in female rats. Thus, pharmacological and/or behavioral inflection of the stress levels is a potential therapeutic approach for prevention of early life stressenhanced obesity and metabolic disease.
C1 [Murphy, Margaret O.; Herald, Joseph B.; Wills, Caleb T.; Unfried, Stanley G.; Cohn, Dianne M.; Loria, Analia S.] Univ Kentucky, Dept Pharmacol & Nutr Sci, 900 S Limestone St,562 CT Wethington Bldg, Lexington, KY 40536 USA.
C3 University of Kentucky
RP Loria, AS (corresponding author), Univ Kentucky, Dept Pharmacol & Nutr Sci, 900 S Limestone St,562 CT Wethington Bldg, Lexington, KY 40536 USA.
EM analia.loria@uky.edu
FU NHLBI NIH HHS [R00 HL111354] Funding Source: Medline; NIGMS NIH HHS [P20
   GM103527] Funding Source: Medline
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NR 64
TC 24
Z9 24
U1 0
U2 1
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0193-1849
EI 1522-1555
J9 AM J PHYSIOL-ENDOC M
JI Am. J. Physiol.-Endocrinol. Metab.
PD FEB
PY 2017
VL 312
IS 2
BP E98
EP E108
DI 10.1152/ajpendo.00308.2016
PG 11
WC Endocrinology & Metabolism; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Physiology
GA EN1XL
UT WOS:000395803600002
PM 27965205
OA Green Published
DA 2025-06-11
ER

PT J
AU Demir, I
   Toker, A
   Zengin, S
   Laloglu, E
   Aksoy, H
AF Demir, Irfan
   Toker, Aysun
   Zengin, Selcuk
   Laloglu, Esra
   Aksoy, Hulya
TI Oxidative stress and insulin resistance in policemen working shifts
SO INTERNATIONAL ARCHIVES OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH
LA English
DT Article
DE Shift system; Oxidative stress; Insulin resistance; Inflammation
ID C-REACTIVE PROTEIN; GELATINASE-ASSOCIATED LIPOCALIN; BETA-CELL FUNCTION;
   METABOLIC SYNDROME; SENSITIVITY; CANCER; SLEEP; DISORDERS; DISEASE;
   OBESITY
AB Shift work is a work schedule involving irregular or unusual hours, compared to those of a normal daytime work schedule. In developed countries, night shift work is very common. In several cities of our country, 12/24 shift system is implemented in police organization. While night shift work composes half of the 20 shift in a month, in ergonomic shift system, an alternative shift schedule, shift work can be performed in three shifts in a day. In this study, we aimed to investigate the effects of 12/24 shift work system on insulin resistance and oxidative stress and systemic inflammation.
   Two hundred and four 12/24 shift workers (age 44.3 +/- A 5.6 years) and 193 ergonomic shift workers (age 42.6 +/- A 5.5 years) were included to study. Serum oxidized LDL (ox-LDL), neutrophil gelatinase lipocalin-2 (NGAL) as oxidative stress markers, glucose, insulin, ferritin, high-sensitive C-reactive protein (hsCRP) and erythrocyte sedimentation rate values were measured. Homeostasis model assessment for insulin resistance (HOMA-IR) was calculated to evaluate insulin resistance.
   Serum ox-LDL, HOMA-IR, hsCRP and NGAL levels in 12/24 shift system were found to be significantly higher compared with ergonomic shift workers (p < 0.0001, p = 0.02, p = 0.03, p = 0.02, respectively). When evaluated all subjects, weak but significant correlation was found between HOMA-IR with ox-LDL (r = 0.12, p = 0.01), hsCRP (r = 0.17, p = 0.001) and ferritin (r = 0.15, r = 0.003). Also in 12/24 shift work group, there were significant correlations between HOMA-IR with hsCRP (r = 0.17, p = 0.01) and ferritin (r = 0.25, p = 0.0001).
   It may be concluded that 12/24 shift system might give rise to insulin resistance and oxidative stress. Additionally, workers in this system may under risk of systemic inflammatory response. Working hours must be arranged in accordance with the physiological rhythm.
C1 [Demir, Irfan] Balikesir Police Dept, Balikesir, Turkey.
   [Toker, Aysun] Necmettin Erbakan Univ, Meram Med Fac, Dept Biochem, Konya, Turkey.
   [Zengin, Selcuk] Gaziantep Police Dept, Gaziantep, Turkey.
   [Laloglu, Esra; Aksoy, Hulya] Ataturk Univ, Fac Med, Dept Biochem, Erzurum, Turkey.
C3 Ministry of Interior - Turkey; Necmettin Erbakan University; Ministry of
   Interior - Turkey; Ataturk University
RP Toker, A (corresponding author), Necmettin Erbakan Univ, Meram Med Fac, Dept Biochem, Konya, Turkey.
EM aysuntoker@gmail.com
RI Demir, Ibrahim/ABI-4695-2020
FU Scientific and Technological Research Council of Turkey (TUBITAK)
   [112S559]
FX This study was financially supported by a research fund from the
   Scientific and Technological Research Council of Turkey (TUBITAK)
   (112S559).
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NR 39
TC 20
Z9 24
U1 0
U2 12
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0340-0131
EI 1432-1246
J9 INT ARCH OCC ENV HEA
JI Int. Arch. Occup. Environ. Health
PD APR
PY 2016
VL 89
IS 3
BP 407
EP 412
DI 10.1007/s00420-015-1079-1
PG 6
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA DG7UI
UT WOS:000372288800004
PM 26228659
DA 2025-06-11
ER

PT J
AU Roca-Rodríguez, MM
   López-Tinoco, C
   Murri, M
   Fernández-Deudero, A
   García-Palacios, MV
   García-Valero, MA
   Tinahones-Madueño, FJ
   Aguilar-Diosdado, M
AF Roca-Rodriguez, M. M.
   Lopez-Tinoco, C.
   Murri, M.
   Fernandez-Deudero, A.
   Garcia-Palacios, M. V.
   Garcia-Valero, M. A.
   Tinahones-Madueno, F. J.
   Aguilar-Diosdado, M.
TI Postpartum development of endothelial dysfunction and oxidative stress
   markers in women with previous gestational diabetes mellitus
SO JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
LA English
DT Article
DE Metabolic syndrome; Endothelial dysfunction; Oxidative stress;
   Gestational diabetes mellitus; Postpartum
ID CIRCULATING ADHESION MOLECULES; CARDIOVASCULAR-DISEASE; E-SELECTIN;
   URIC-ACID; INSULIN-RESISTANCE; NORMAL-PREGNANCY; SOLUBLE FORMS; RISK;
   ATHEROSCLEROSIS; ASSOCIATION
AB Relationships between adhesion molecules (AM), oxidative stress, gestational diabetes mellitus (GDM) and future development of type 2 diabetes mellitus are unclear.
   We investigated AM and oxidant/antioxidant markers in women with previous history of GDM.
   Postpartum women with GDM (cases; n = 41) and healthy women (controls; n = 21) had clinical and laboratory variables measured, including indicators of vascular damage (ICAM-1, VCAM-1 and E-selectin), oxidative stress (LPO, GSH and GST) and antioxidant markers (catalase, SOD, GPX and TAC).
   Previous GDM versus control women presented higher body mass index: 27.4 +/- A 5.6 versus 23.9 +/- A 3.6 (p = 0.013); waist circumference: 85.2 +/- A 12.9 versus 77.5 +/- A 9.0 (p = 0.017); MetS (WHO definition): 14.6 versus 0 % (p = 0.012); MetS (NCEP-ATPIII definition): 22 versus 0 % (p = 0.002); low HDL: 36.6 versus 9.5 % (p = 0.024); fasting glucose (mmol/L): 5.4 +/- A 0.6 versus 4.9 +/- A 0.2 (p < 0.001); glucose 120 min (mg/dL): 105.0 +/- A 30.2 versus 85.1 +/- A 14.2 (p = 0.007); fasting insulin (mu U/mL): 13.4 +/- A 8.1 versus 8.4 +/- A 4.3 (p = 0.004); HOMA index: 3.3 +/- A 2.3 versus 1.8 +/- A 1.0 (p = 0.002); HbA1c (%/mmol/mol): 5.4 +/- A 0.2 versus 5.2 +/- A 0.2/36 +/- A 1.4 versus 33 +/- A 1.4 (p = 0.021); uric acid (mg/dL): 4.1 +/- A 1 versus 3.5 +/- A 0.6 (p = 0.009); catalase (nmol/min/mL): 38.7 +/- A 15.6 versus 28.9 +/- A 11.1 (p = 0.013). There were no significant differences in hypertension prevalence, lipid fractions, albumin/creatinine ratio and AM.
   Women with previous GDM have high catalase levels which correlate positively with glucose intolerance, indicating the potential effect of oxidative stress on postpartum dysglycemic status.
C1 [Roca-Rodriguez, M. M.; Tinahones-Madueno, F. J.] Virgen de la Victoria Hosp, Dept Endocrinol & Nutr, Malaga, Spain.
   [Roca-Rodriguez, M. M.; Murri, M.; Tinahones-Madueno, F. J.] Virgen de la Victoria Hosp, Invest Unit IMABIS, Malaga, Spain.
   [Lopez-Tinoco, C.; Garcia-Valero, M. A.; Aguilar-Diosdado, M.] Puerta del Mar Hosp, Dept Endocrinol & Nutr, Cadiz 11009, Spain.
   [Fernandez-Deudero, A.; Aguilar-Diosdado, M.] Puerta del Mar Hosp, Invest Unit, Cadiz 11009, Spain.
   [Garcia-Palacios, M. V.] Puerta del Mar Hosp, Dept Prevent Med & Publ Hlth, Cadiz 11009, Spain.
C3 Universidad de Cadiz; Hospital Universitario Puerta del Mar; Universidad
   de Cadiz; Hospital Universitario Puerta del Mar; Universidad de Cadiz;
   Hospital Universitario Puerta del Mar
RP Aguilar-Diosdado, M (corresponding author), Puerta del Mar Hosp, Dept Endocrinol & Nutr, Ana Viya 21, Cadiz 11009, Spain.
EM maroca80@gmail.com; manuel.aguilar.sspa@juntadeandalucia.es
RI Tinahones, Francisco/AAB-2882-2020; Lopez-Tinoco, Cristina/K-5420-2019;
   Aguilar Diosdado, Manuel/A-2549-2009
OI Garcia Palacios, Maria Victoria/0000-0002-2003-0966; Aguilar Diosdado,
   Manuel/0000-0001-9657-5949; Tinahones, Francisco J/0000-0001-6871-4403;
   Murri, Mora/0000-0002-6482-192X; Fernandez Deudero,
   Alvaro/0009-0007-3292-3933
FU Andalusia Department of Health [CTS-368]
FX This study was financed, in part, by grants from the Andalusia
   Department of Health (CTS-368). Editorial assistance was by Dr. Peter R
   Turner.
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NR 25
TC 28
Z9 29
U1 0
U2 14
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1720-8386
J9 J ENDOCRINOL INVEST
JI J. Endocrinol. Invest.
PD JUN
PY 2014
VL 37
IS 6
BP 503
EP 509
DI 10.1007/s40618-013-0045-6
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA AI3BH
UT WOS:000336732900001
PM 24458829
DA 2025-06-11
ER

PT J
AU Sebeková, K
   Somoza, V
   Jarcusková, M
   Heidland, A
   Podracká, L
AF Sebekova, Katarina
   Somoza, Veronika
   Jarcuskova, Monika
   Heidland, August
   Podracka, Ludmila
TI Plasma advanced glycation end products are decreased in obese children
   compared with lean controls
SO INTERNATIONAL JOURNAL OF PEDIATRIC OBESITY
LA English
DT Article
DE Advanced glycation end products; CML; fructoselysine; microinflammation;
   insulin sensitivity; 8-OHdG; oxidative stress; sRAGE
ID OXIDATIVE DNA-DAMAGE; SUBTOTALLY NEPHRECTOMIZED RATS; C-REACTIVE
   PROTEIN; DIETARY GLYCOTOXINS; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   ADIPOSE-TISSUE; RENAL-DISEASE; VITAMIN-C; INFLAMMATION
AB Objective. In obesity, the combined effects of enhanced food consumption, enhanced oxidative stress and microinflammation could augment the advanced glycation end products (AGEs) accumulation in plasma. We compared the plasma concentrations of AGEs and the soluble receptor for AGEs (sRAGE) in relation to markers of oxidative stress, microinflammation and renal function in obese and lean children/adolescents. Methods. In 18 apparently healthy obese children/adolescents (7 females/11 males; age: 5-18 years; body mass index, BMI: 27.33.3 kg/m2) and 18 healthy lean controls (10 females/8 males; age: 4-17 years, BMI: 22.42.1 kg/m2) the plasma concentration of N-carboxymethyllysine (CML), fructoselysine (FL), AGE-associated fluorescence, sRAGE, high sensitive-C-reactive protein (hsCRP), interleukin-6 (IL-6) and urinary 8-hydroxy-2-deoxyguanosine (U-8-OHdG) excretion, plasma advanced oxidation protein products (AOPPs), renal function, and the HOMA index of insulin resistance were determined. Results. Obese children/adolescents had significantly lower concentrations of plasma FL (6.80.3 mmol/mol lysine vs. 7.70.3, p0.02), CML (0.140.03 mmol/mol lysine vs. 0.220.04, p0.001), and fluorescent AGEs (22337 arbitrary units (AU) vs. 31864, p0.01) than their lean counterparts. Plasma sRAGE concentration did not differ (2.30.6 ng/ml vs. 2.60.6). Obese children/adolescents were more insulin-resistant (HOMA index: p0.01), exhibited higher levels of markers of inflammation (hs-CRP: p0.03; IL-6: p0.02), of oxidative stress (AOPPs: p0.05; 8-OHdG: p0.04) and had a higher creatinine clearance (p0.01) and proteinuria (p0.01). Conclusions. We present the first evidence that childhood/adolescent obesity is characterized by lower plasma AGE levels, despite lower insulin sensitivity, enhanced oxidative stress and microinflammation. An enhanced removal of AGE peptides via hyperfiltration may partially contribute to the lower plasma AGE levels.
C1 [Sebekova, Katarina] Slovak Med Univ, Dept Clin & Expt Pharmacotherapy, Bratislava 83303, Slovakia.
   [Somoza, Veronika] German Res Ctr Food Chem, Garching, Germany.
   [Jarcuskova, Monika; Podracka, Ludmila] Safarik Univ, Dept Paediat 1, Fac Med, Kosice, Slovakia.
   [Heidland, August] Univ Wurzburg, Wurzburg, Germany.
C3 Slovak Medical University Bratislava; Leibniz Association;
   Leibniz-Institute for Food Systems Biology at the Technical University
   of Munich; University of Pavol Jozef Safarik Kosice; University of
   Wurzburg
RP Sebeková, K (corresponding author), Slovak Med Univ, Dept Clin & Expt Pharmacotherapy, Limbova 14, Bratislava 83303, Slovakia.
EM katarina.sebekova@szu.sk
RI ; Sebekova, Katarina/H-4906-2016; Somoza, Veronika/D-4141-2013
OI Podracka, Ludmila/0000-0002-6633-0251; Sebekova,
   Katarina/0000-0002-9641-9265; Somoza, Veronika/0000-0003-2456-9245
FU Verein zur Bekampfung der Hochdruck-und Nierenkrankheiten Wurzburg e.
   V., Germany; Ministry of Health of the Slovak Republic [2005/1-DFNKE-01]
FX The authors would like to thank Mr. Andree Klassen from Wurzburg for his
   constructive support in drafting the manuscript. This study was
   supported in part by the Verein zur Bekampfung der Hochdruck-und
   Nierenkrankheiten Wurzburg e. V., Germany, and a research grant from the
   Ministry of Health of the Slovak Republic, No. 2005/1-DFNKE-01.
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NR 52
TC 64
Z9 67
U1 1
U2 13
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 1747-7166
EI 1747-7174
J9 INT J PEDIATR OBES
JI Int. J. Pediatr. Obes.
PY 2009
VL 4
IS 2
BP 112
EP 118
AR PII 795160050
DI 10.1080/17477160802248039
PG 7
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA 445XU
UT WOS:000266085600007
PM 18645732
DA 2025-06-11
ER

PT J
AU Diniz, YS
   Faine, LA
   Galhardi, CM
   Rodrigues, HG
   Ebaid, GX
   Burneiko, RC
   Cicogna, AC
   Novelli, ELB
AF Diniz, YS
   Faine, LA
   Galhardi, CM
   Rodrigues, HG
   Ebaid, GX
   Burneiko, RC
   Cicogna, AC
   Novelli, ELB
TI Monosodium glutamate in standard and high-fiber diets: metabolic
   syndrome and oxidative stress in rats
SO NUTRITION
LA English
DT Article
DE diets; monosodium glutamate; fiber; metabolic parameters; oxidative
   stress; rats
ID INSULIN-SENSITIVE TISSUES; GLUT-4 CONTENT; OBESITY; RESTRICTION;
   GLUCOSE; TASTE; CHROMATOGRAPHY; HYPERTENSION; ANTIOXIDANTS; PLASMA
AB Objective: This study determined the effects of adding monosodium, glutamate (MSG) to a standard diet and a fiber-enriched diet on glucose metabolism, lipid profile, and oxidative stress in rats.
   Methods: Male Wistar rats (65 +/- 5 g, n = 8) were fed a standard diet (control), a standard diet supplemented with 100 g of MSG per kilogram of rat body weight, a diet rich,in fiber, or a diet rich in fiber supplemented with 100 g of MSG per kilogram of body weight. After 45 d of treatment, sera were analyzed for concentrations of insulin, leptin, glucose, triacylglycerol, lipid hydroperoxide, and total antioxidant substances. A homeostasis model assessment index was estimated to characterize insulin resistance.
   Results: Voluntary food intake was higher and feed efficiency was lower in animals fed the standard diet supplemented with MSG than in those fed the control, fiber-enriched, or fiber- and MSG-enriched diet. The MSG group had metabolic dysfunction characterized by increased levels of glucose, triacylglycerol, insulin, leptin, and homeostasis model assessment index. The adverse effects of MSG were related to an imbalance between the oxidant and antioxidant systems. The MSG group had increased levels of lipid hydroperoxide and decreased. levels of total antioxidant substances. Levels of triacylglycerol and lipid hydroperoxide were decreased in rats fed the fiber-enriched and fiber- and MSG-enriched diets, whereas levels of total antioxidant substances were increased in these animals.
   Conclusions: MSG added to a standard diet increased food intake. Overfeeding induced metabolic disorders associated with oxidative stress in the absence of obesity. The fiber-enriched diet prevented changes in glucose, insulin, leptin, and triacylglycerol levels that were seen in the MSG group. Because the deleterious effects of MSG, i.e., induced overfeeding, were not seen in the animals fed the fiber-enriched diets, it can be concluded that fiber supplementation is beneficial by discouraging overfeeding and improving oxidative stress that is induced by an MSG diet. (c) 2005 Elsevier Inc. All rights reserved.
C1 Univ Sao Paulo, Dept Chem & Biochem, Inst Biol Sci, Sao Paulo, Brazil.
   Univ Sao Paulo, Fac Med, Dept Clin Cardiol, Sao Paulo, Brazil.
C3 Universidade de Sao Paulo; Universidade de Sao Paulo
RP Univ Sao Paulo, Dept Chem & Biochem, Inst Biol Sci, Sao Paulo, Brazil.
EM drno@uol.com.br
RI Rodrigues, Hosana/E-3060-2012; Galhardi, Cristiano/M-6903-2019;
   Galhardi, Cristiano Machado/P-5528-2016
OI Galhardi, Cristiano Machado/0000-0001-8741-1336; Cicogna, Antonio
   Carlos/0000-0002-4402-6523; Rodrigues, Hosana/0000-0002-6122-0379
CR Association of Official Analytical Chemists, 1990, OFF METH AN
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NR 46
TC 95
Z9 105
U1 3
U2 13
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0899-9007
EI 1873-1244
J9 NUTRITION
JI Nutrition
PD JUN
PY 2005
VL 21
IS 6
BP 749
EP 755
DI 10.1016/j.nut.2004.10.013
PG 7
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 932DL
UT WOS:000229534300016
PM 15925301
DA 2025-06-11
ER

PT J
AU Vincent, HK
   Bourguignon, CM
   Vincent, KR
   Weltman, AL
   Bryant, M
   Taylor, G
AF Vincent, Heather K.
   Bourguignon, Cheryl M.
   Vincent, Kevin R.
   Weltman, Arthur L.
   Bryant, Mary
   Taylor, G.
TI Antioxidant supplementation lowers exercise-induced oxidative stress in
   young overweight adults
SO OBESITY
LA English
DT Article
DE antioxidant; inflammation; adiponectin; exercise; lipid peroxidation
ID ALPHA-TOCOPHEROL; VITAMIN-C; LIPID-PEROXIDATION; BETA-CAROTENE; DIET
   SUPPLEMENTATION; METABOLIC SYNDROME; OXIDANT STRESS; BLOOD MARKERS;
   OBESE WOMEN; DNA-DAMAGE
AB Objective: To determine whether antioxidant (AOX) supplementation attenuates post-exercise oxidative stress and contributors to oxidative stress (inflammation, blood lipids) in overweight young adults.
   Research Methods and Procedures: This was a randomized, double-blind, controlled study. Overweight (BMI 33.2 +/- 1.9 kg/m(2)) and comparative normal-weight (BMI 21.9 +/- 0.5 kg/m(2)) adults 18 to 30 years old (total N = 48) were enrolled. Participants received either daily antioxidant (AOX) treatment (800 IU of vitamin E, 500 mg of vitamin C, 10 mg of beta-carotene) or placebo (PL) for 8 weeks for a total of four groups. All participants completed a standardized 30-minute cycle exercise bout at baseline and 8 weeks. Exercise-induced changes in lipid hydroperoxide (Delta PEROX), C-reactive protein (Delta CRP), interleukin-6 (Delta IL-6), cholesterol subtractions, triglycerides, total AOX status (Delta TAS), and adiponectin were assessed.
   Results: Exercise-induced Delta PEROX was lower in the over-weight-AOX group (0.09 nM/kg per min) compared with PL-treated overweight and normal-weight groups (0.98, 0.53 nM/kg per min) by 8 weeks (p < 0.05). Adiponectin was increased in both overweight and normal-weight AOX groups (22.1% vs. 3.1%; p < 0.05) but reduced in PL groups. Delta IL-6, Delta total cholesterol, and Delta low-density lipoprotein-chol esterol concentrations during exercise were lower in the AOX-treated groups compared with PL groups (all p < 0.05). After controlling for BMI, the Delta total cholesterol, Delta low-density lipoprotein-cholesterol, Delta adiponectin, and Delta TAS5 explained 59.1% of the variance of the regression model of the Delta PEROX by 8 weeks (total model R = 0.600; p = 0.015).
   Discussion: AOX lowers exercise-induced oxidative stress in overweight adults. Inflammatory and lipid markers may also be attenuated with AOX. Further studies are needed to determine whether AOX may be used in cardiovascular disease prevention in the overweight population.
C1 Univ Virginia Hlth Syst, Gen Clin Res Ctr, Charlottesville, VA USA.
   Univ Virginia Hlth Syst, Dept Phys Med & Rehabil, Charlottesville, VA USA.
   Univ Virginia Hlth Syst, Dept Human Serv, Charlottesville, VA USA.
   Univ Virginia Hlth Syst, Dept Internal Med, Charlottesville, VA USA.
   Univ Virginia Hlth Syst, Ctr Study Complementary & Alternat Therapies, Charlottesville, VA USA.
C3 University of Virginia; University of Virginia (UVA) Health System;
   University of Virginia; University of Virginia (UVA) Health System;
   University of Virginia; University of Virginia (UVA) Health System;
   University of Virginia; University of Virginia (UVA) Health System;
   University of Virginia; University of Virginia (UVA) Health System
RP Vincent, HK (corresponding author), Univ Virginia, Ctr Study Complementary & Alternat Therapies, Blake Ctr, POB 800905, Charlottesville, VA 22908 USA.
EM hvincent@adelphia.net
RI Vincent, Heather/ABH-4566-2020
OI Weltman, Arthur/0000-0002-0125-3769; Vincent,
   Heather/0000-0003-2177-1683
FU NCCIH NIH HHS [K30-AT-00060, T32-AT00052] Funding Source: Medline; NCRR
   NIH HHS [5 M01 RR000847] Funding Source: Medline
CR [Anonymous], 2000, ACSMS GUIDELINES EXE
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NR 49
TC 46
Z9 55
U1 0
U2 14
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1930-7381
EI 1930-739X
J9 OBESITY
JI Obesity
PD DEC
PY 2006
VL 14
IS 12
BP 2224
EP 2235
DI 10.1038/oby.2006.261
PG 12
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 212OH
UT WOS:000249606200015
PM 17189550
OA Bronze
DA 2025-06-11
ER

PT J
AU Dhibi, M
   Brahmi, F
   Mnari, A
   Houas, Z
   Chargui, I
   Bchir, L
   Gazzah, N
   Alsaif, MA
   Hammami, M
AF Dhibi, Madiha
   Brahmi, Faten
   Mnari, Amira
   Houas, Zohra
   Chargui, Issam
   Bchir, Linda
   Gazzah, Noureddine
   Alsaif, Mohammed A.
   Hammami, Mohamed
TI The intake of high fat diet with different trans fatty acid levels
   differentially induces oxidative stress and non alcoholic fatty liver
   disease (NAFLD) in rats
SO NUTRITION & METABOLISM
LA English
DT Article
DE trans fatty acids; oxidative stress; non alcoholic fatty liver disease;
   rats
ID VIRGIN OLIVE; SUPEROXIDE-DISMUTASE; LIPID-COMPOSITION; HDL CHOLESTEROL;
   ANTIOXIDANTS; OILS; PHOSPHOLIPIDS; CONSEQUENCES; INFLAMMATION;
   CONSUMPTION
AB Background: Trans-fatty acids (TFA) are known as a risk factor for coronary artery diseases, insulin resistance and obesity accompanied by systemic inflammation, the features of metabolic syndrome. Little is known about the effects on the liver induced by lipids and also few studies are focused on the effect of foods rich in TFAs on hepatic functions and oxidative stress. This study investigates whether high-fat diets with different TFA levels induce oxidative stress and liver dysfunction in rats.
   Methods: Male Wistar rats were divided randomly into four groups (n = 12/group): C receiving standard-chow; Experimental groups that were fed high-fat diet included 20% fresh soybean oil diet (FSO), 20% oxidized soybean oil diet (OSO) and 20% margarine diet (MG). Each group was kept on the treatment for 4 weeks.
   Results: A liver damage was observed in rats fed with high-fat diet via increase of liver lipid peroxidation and decreased hepatic antioxidant enzyme activities (superoxide dismutase, catalase and glutathione peroxidase). The intake of oxidized oil led to higher levels of lipid peroxidation and a lower concentration of plasma antioxidants in comparison to rats fed with FSO. The higher inflammatory response in the liver was induced by MG diet. Liver histopathology from OSO and MG groups showed respectively moderate to severe cytoplasm vacuolation, hypatocyte hypertrophy, hepatocyte ballooning, and necroinflammation.
   Conclusion: It seems that a strong relationship exists between the consumption of TFA in the oxidized oils and lipid peroxidation and non alcoholic fatty liver disease (NAFLD). The extent of the peroxidative events in liver was also different depending on the fat source suggesting that feeding margarine with higher TFA levels may represent a direct source of oxidative stress for the organism. The present study provides evidence for a direct effect of TFA on NAFLD.
C1 [Dhibi, Madiha; Brahmi, Faten; Mnari, Amira; Bchir, Linda; Gazzah, Noureddine; Hammami, Mohamed] Fac Med Monastir, UR Human Nutr & Metab Disorder, Biochem Lab, Monastir 5019, Tunisia.
   [Houas, Zohra; Chargui, Issam] Fac Med, Lab Histol Cytol & Genet, Monastir 5019, Tunisia.
   [Alsaif, Mohammed A.; Hammami, Mohamed] King Saud Univ, Coll Appl Med Sci, VPP Unit, Riyadh, Saudi Arabia.
C3 Universite de Monastir; Universite de Monastir; King Saud University
RP Dhibi, M (corresponding author), Fac Med Monastir, UR Human Nutr & Metab Disorder, Biochem Lab, Monastir 5019, Tunisia.
EM madiha.dhibi@hotmail.fr; mohamed.hammami@fmm.mu.tn
OI Mnari, Amira/0000-0001-7519-4637
FU Ministere de l'Enseignement Superieur et de la Recherche Scientifique
   [UR03ES08]
FX This research was supported by a grant from the 'Ministere de
   l'Enseignement Superieur et de la Recherche Scientifique" UR03ES08
   "Nutrition Humaine et Desordres Metaboliques" University of Monastir and
   'DRT-USCR-Spectrometrie de masse. We are grateful to the anonymous
   reviewers for their valuable comments and remarks. We thank Mr. Arafet
   Dhibi for the critical review English Grammar of the manuscript.
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NR 66
TC 130
Z9 139
U1 2
U2 37
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1743-7075
J9 NUTR METAB
JI Nutr. Metab.
PD SEP 23
PY 2011
VL 8
AR 65
DI 10.1186/1743-7075-8-65
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 832UJ
UT WOS:000295833700001
PM 21943357
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Gatineau, E
   Savary-Auzeloux, I
   Migné, C
   Polakof, S
   Dardevet, D
   Mosoni, L
AF Gatineau, Eva
   Savary-Auzeloux, Isabelle
   Migne, Carole
   Polakof, Sergio
   Dardevet, Dominique
   Mosoni, Laurent
TI Chronic Intake of Sucrose Accelerates Sarcopenia in Older Male Rats
   through Alterations in Insulin Sensitivity and Muscle Protein Synthesis
SO JOURNAL OF NUTRITION
LA English
DT Article
DE sarcopenia; protein synthesis; fructose; antioxidant; insulin
   sensitivity; rats
ID HIGH-FRUCTOSE DIET; LEAN MASS-LOSS; METABOLIC SYNDROME; OXIDATIVE
   STRESS; SKELETAL-MUSCLE; WISTAR RATS; AMINO-ACIDS; RESISTANCE;
   INFLAMMATION; RUTIN
AB Background: Today, high chronic intake of added sugars is frequent, which leads to inflammation, oxidative stress, and insulin resistance. These 3 factors could reduce meal-induced stimulation of muscle protein synthesis and thus aggravate the age-related loss of muscle mass (sarcopenia).
   Objectives: Our aims were to determine if added sugars could accelerate sarcopenia and to assess the capacity of antioxidants and anti-inflammatory agents to prevent this. Methods: For 5 mo, 16-mo-old male rats were starch fed (13% sucrose and 49% wheat starch diet) or sucrose fed (62% sucrose and 0% wheat starch diet) with or without rutin (5 g/kg diet), vitamin E (4 times), vitamin A (2 times), vitamin D (5 times), selenium (10 times), and zinc (+44%) (R) supplementation. We measured the evolution of body composition and inflammation, plasma insulin-like growth factor 1 (IGF-I) concentration and total antioxidant status, insulin sensitivity (oral-glucose-tolerance test), muscle weight, superoxide dismutase activity, glutathione concentration, and in vivo protein synthesis rates.
   Results: Sucrose-fed rats lost significantly more lean body mass (-8.1% vs. 5.4%, respectively) and retained more fat mass (+0.2% vs. -33%, respectively) than starch-fed rats. Final muscle mass was 11% higher in starch-fed rats than in sucrose-fed rats. Sucrose had little effect on inflammation, oxidative stress, and plasma IGF-I concentration but reduced the insulin sensitivity index (divided by 2). Meal-induced stimulation of muscle protein synthesis was significantly lower in sucrose-fed rats (+7.3%) than in starch-fed rats (+22%). R supplementation slightly but significantly reduced oxidative stress and increased muscle protein concentration (+4%) but did not restore postprandial stimulation of muscle protein synthesis.
   Conclusions: High chronic sucrose intake accelerates sarcopenia in older male [rate through an alteration of postprandial stimulation of muscle protein synthesis. This effect could be explained by a decrease of insulin sensitivity rather than by changes in plasma IGF-I, inflammation, and/or oxidative stress.
C1 [Gatineau, Eva; Savary-Auzeloux, Isabelle; Migne, Carole; Polakof, Sergio; Dardevet, Dominique; Mosoni, Laurent] Natl Inst Agron Res, Joint Res Unit Human Nutr 1019, St Genes Champanelle, France.
   [Gatineau, Eva; Savary-Auzeloux, Isabelle; Migne, Carole; Polakof, Sergio; Dardevet, Dominique; Mosoni, Laurent] Clermont 1 Univ, Res & Training Unit Med, Joint Res Unit Human Nutr 1019, Clermont Ferrand, France.
C3 INRAE; Universite Clermont Auvergne (UCA)
RP Mosoni, L (corresponding author), Natl Inst Agron Res, Joint Res Unit Human Nutr 1019, St Genes Champanelle, France.
EM laurent.mosoni@clermont.inra.fr
RI Dardevet, Dominique/IAM-3666-2023; Gatineau, Eva/S-7508-2018; Polakof,
   Sergio/V-1132-2017; Mosoni, Laurent/KUF-0702-2024
OI Polakof, Sergio/0000-0002-0976-8732; Savary-Auzeloux,
   Isabelle/0000-0002-3298-9787; Dardevet, Dominique/0000-0001-7320-9970;
   Mosoni, Laurent/0000-0002-5409-6760
FU National Institute of Agronomic Research (INRA), France
FX Supported by the National Institute of Agronomic Research (INRA),
   France.
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NR 50
TC 31
Z9 34
U1 2
U2 35
PU AMER SOC NUTRITION-ASN
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-3166
EI 1541-6100
J9 J NUTR
JI J. Nutr.
PD MAY
PY 2015
VL 145
IS 5
BP 923
EP 930
DI 10.3945/jn.114.205583
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA CH4OO
UT WOS:000354013000012
PM 25809681
OA Bronze
DA 2025-06-11
ER

PT J
AU Erdogan, M
   Karadeniz, M
   Berdeli, A
   Alper, G
   Caglayan, O
   Yilmaz, C
AF Erdogan, M.
   Karadeniz, M.
   Berdeli, A.
   Alper, G.
   Caglayan, O.
   Yilmaz, C.
TI The relationship of the interleukin-6-174 G&gt;C gene polymorphism with
   oxidative stress markers in Turkish polycystic ovary syndrome patients
SO JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
LA English
DT Article
DE Interleukin-6 gene polymorphism; oxidative stress markers; polycystic
   ovary syndrome
ID CORONARY-ARTERY-DISEASE; NITRIC-OXIDE; CARDIOVASCULAR RISK; PROMOTER
   POLYMORPHISM; INSULIN-RESISTANCE; HOMOCYSTEINE CONCENTRATIONS;
   MYOCARDIAL-INFARCTION; METABOLIC SYNDROME; DIABETES-MELLITUS;
   PLASMA-GLUCOSE
AB Objective. Interleukin-6 (IL-6) is a key pro-inflammatory and immune-modulatory cytokine of relevance for cardiovascular (CID) diseases. Cardiovascular risk factors that have been reported include oxydative stress markers [nitric oxide (NO), malondialdehyde (MDA), disulphite (SH)l. We aimed to evaluate the relation between the IL-6 G/C gene polymorphism and oxidative stress markers in polycystic ovary syndrome (PCOS) patients. Design and patients: We studied 85 PCOS patients and 115 healthy controls. PCOS was defined by the Rotterdam PCOS consensus criteria. Results: The genotype IL-6 distribution did differ between the control group (CC 9.6%, GC 63.4%, GG 27.0%) and the PCOS patients (CC 4.7%, GC 29.4%, GG 65.9%) (p<0.001). The frequency of the polymorphic G allele was also not similar for the group with PCOS as for the control group with 80.6% and 58.7%, respectively (p<0.001). No statistically significant difference was determined for MDA and NO levels in PCOS patients and control group (p>0.05). Only SH levels were found to be high in favor of patient group (p<0.05). No statistically significant difference was determined between IL-6 G/C gene polymorphism and oxidative stress markers in PCOS patients and in the control group. Conclusion: Gene polymorphism of IL-6 -174 G>C is a risk factor for PCOS in Turkish patients. IL-6 gene polymorphisms are not related to NO, MDA, and SH levels in PCOS. Our negative results in risks factors of CV disorders can probably be explained by the fact that metabolic parameters and endothelial systems of patients may not yet be affected in this short period of time. (J. Endocrinol. Invest. 31: 624-629, 2008) (C) 2008, Editrice Kurtis
C1 [Erdogan, M.; Karadeniz, M.; Yilmaz, C.] Ege Univ, Sch Med, Dept Endocrinol & Metab Dis, TR-35100 Izmir, Turkey.
   [Berdeli, A.] Ege Univ, Sch Med, Dept Pediat, Mol Med Lab, TR-35100 Izmir, Turkey.
   [Alper, G.] Ege Univ, Sch Med, Dept Biochem, TR-35100 Izmir, Turkey.
   [Caglayan, O.] Kirikkale Univ, Sch Med, Dept Biochem, Izmir, Turkey.
C3 Ege University; Ege University; Ege University; Kirikkale University
RP Erdogan, M (corresponding author), Ege Univ, Sch Med, Dept Endocrinol & Metab Dis, TR-35100 Izmir, Turkey.
EM drmerdogan61@yahoo.com
RI karadeniz, muammer/L-8819-2013; Erdoğan, Mehmet/JAC-5515-2023
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NR 56
TC 24
Z9 24
U1 0
U2 3
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0391-4097
EI 1720-8386
J9 J ENDOCRINOL INVEST
JI J. Endocrinol. Invest.
PD JUL
PY 2008
VL 31
IS 7
BP 624
EP 629
DI 10.1007/BF03345614
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 358GQ
UT WOS:000259905500010
PM 18787381
DA 2025-06-11
ER

PT J
AU Szot, W
   Zajac, J
   Kubinyi, A
   Kostkiewicz, M
AF Szot, Wojciech
   Zajac, Joanna
   Kubinyi, Aleksandra
   Kostkiewicz, Magdalena
TI The effects of cardiac rehabilitation on overall physical capacity and
   myocardial perfusion in women with microvascular angina
SO KARDIOLOGIA POLSKA
LA English
DT Article
DE cardiac rehabilitation; myocardial perfusion imaging; microvascular
   angina
ID CARDIOVASCULAR MAGNETIC-RESONANCE; CORONARY-ARTERY-DISEASE; SYNDROME-X;
   CHEST-PAIN; DYSFUNCTION; GUIDELINES; ISCHEMIA; ABSENCE; HEART; WISE
AB Background: Cardiac syndrome X (CSX) is linked with changes in microcirculation, without significant changes in main coronary vessels. According to European Society of Cardiology 2013 stable coronary artery disease (CAD) criteria, CSX was replaced by microvascular angina (MA). The main feature of MA should be regional myocardial ischaemia; however, there are several works on this subject which failed to demonstrate the presence of perfusion defects.
   Aim: To determine the effect of non-pharmacological procedures (cardiac rehabilitation) in patients diagnosed with MA on changes in left ventricular perfusion as assessed by myocardial single photon emission computed tomography, along with potential related improvements in exercise capacity.
   Methods: Toward this goal we screened for the presence of CAD in a group of 528 women, of whom 55 were not only diagnosed with MA but also agreed to participate in our study, which involved myocardial perfusion imaging (MPI) studies, during which exercise tests and cardiac rehabilitation were performed.
   Results: Comparison of results obtained at the beginning of the study with data obtained after completion of a three month period of cardiac rehabilitation showed improvements in both exercise test parameters (length of test, metabolic equivalents, blood pressure control during extortion) and MPI parameters for the left ventricle (both at rest and stress, global and regional).
   Conclusions: Cardiac rehabilitation is a very useful tool of choice in the treatment of patients with MA.
C1 [Szot, Wojciech; Zajac, Joanna] Jagiellonian Univ, Coll Med, Hyg & Dietet Dept, Ul Kopernika 7, PL-31034 Krakow, Poland.
   [Szot, Wojciech; Kostkiewicz, Magdalena] John Paul 2 Hosp, Dept Nucl Med, Krakow, Poland.
   [Kubinyi, Aleksandra] Belluga Med Rehabil Ctr, Krakow, Poland.
   [Kostkiewicz, Magdalena] Jagiellonian Univ, Dept Cardiac & Vasc Dis, Coll Med, PL-31034 Krakow, Poland.
C3 Jagiellonian University; Collegium Medicum Jagiellonian University;
   Jagiellonian University; Collegium Medicum Jagiellonian University
RP Szot, W (corresponding author), Jagiellonian Univ, Coll Med, Hyg & Dietet Dept, Ul Kopernika 7, PL-31034 Krakow, Poland.
EM mcszot@cyf-kr.edu.pl
RI Kostkiewicz, Magdalena/ABH-7357-2020; Zajac, Joanna/ABD-4261-2020
OI Zajac, Joanna/0000-0001-7503-5847; Kostkiewicz,
   Magdalena/0000-0001-9094-3202
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NR 24
TC 22
Z9 26
U1 0
U2 5
PU VIA MEDICA
PI GDANSK
PA UL SWIETOKRZYSKA 73, 80-180 GDANSK, POLAND
SN 0022-9032
EI 1897-4279
J9 KARDIOL POL
JI Kardiol. Pol.
PY 2016
VL 74
IS 5
BP 431
EP 438
DI 10.5603/KP.a2015.0198
PG 8
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA DP6VS
UT WOS:000378637900005
PM 26412475
OA hybrid
DA 2025-06-11
ER

PT J
AU Groussard, C
   Maillard, F
   Vazeille, E
   Barnich, N
   Sirvent, P
   Otero, YF
   Combaret, L
   Madeuf, E
   Sourdrille, A
   Delcros, G
   Etienne, M
   Teixeira, A
   Sauvanet, P
   Pialoux, V
   Boisseau, N
AF Groussard, Carole
   Maillard, Florie
   Vazeille, Emilie
   Barnich, Nicolas
   Sirvent, Pascal
   Otero, Yolanda F.
   Combaret, Lydie
   Madeuf, Elise
   Sourdrille, Antoine
   Delcros, Geoffroy
   Etienne, Monique
   Teixeira, Allison
   Sauvanet, Pierre
   Pialoux, Vincent
   Boisseau, Nathalie
TI Tissue-Specific Oxidative Stress Modulation by Exercise: A Comparison
   between MICT and HIIT in an Obese Rat Model
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Article
ID INSULIN-RESISTANCE; METABOLIC SYNDROME; MODERATE EXERCISE;
   PHYSICAL-ACTIVITY; OXIDANT STRESS; ADIPOSE-TISSUE; LIPID-CONTENT; FAT
   MASS; INTENSITY; INFLAMMATION
AB Background and Aim. Exercise is an effective strategy to reduce obesity-induced oxidative stress. The purpose of this study was to compare the effects of two training modalities (moderate-intensity continuous training (MICT) and high-intensity interval training (HIIT)) on the pro/antioxidant status of different tissues in obese Zucker rats. Methods. Eight-week-old male Zucker rats (fa/fa, n = 36) were subdivided in three groups: MICT, HIIT, and control (no exercise) groups. Trained animals ran on a treadmill (0 degrees slope), 5 days/week for 10 weeks (MICT: 51 min at 12 m.min(-1); HIIT: 6 sets of 3 min at 10 m.min(-1) followed by 4 min at 18 m.min(-1)). Epididymal (visceral) and subcutaneous adipose tissue, gastrocnemius muscle, and plasma samples were collected to measure oxidative stress markers (advanced oxidation protein products (AOPP), oxidized low-density lipoprotein (oxLDL)), antioxidant system markers (ferric-reducing ability of plasma (FRAP), superoxide dismutase (SOD), catalase, and glutathione peroxidase (GPx) activities), and prooxidant enzymes (NADPH oxidase and xanthine oxidase (XO) activities, myeloperoxidase content). Results. Compared with the control, MICT increased GPx and catalase activities and the FRAP level in epididymal adipose tissue. HIIT increased the AOPP level in subcutaneous adipose tissue. In the muscle, HIIT increased both SOD and GPx activities and reduced the AOPP level, whereas MICT increased only SOD activity. Finally, plasma myeloperoxidase content was similarly decreased by both training modalities, whereas oxLDL was reduced only in the MICT group. Conclusion. Both Hill' and MILT' improved the pro/antioxidant status. However, Hill' was more efficient than MICT in the skeletal muscle, whereas MICT was more efficient in epididymal adipose tissue. This suggests that oxidative stress responses to HIIT and MICT are tissue-specific. This could result in ROS generation via different pathways in these tissues. From a practical point of view, the two training modalities should be combined to obtain a global response in people with obesity.
C1 [Groussard, Carole] Univ Rennes, Lab M2S, EA 7470, F-35000 Rennes, France.
   [Maillard, Florie; Sirvent, Pascal; Otero, Yolanda F.; Sourdrille, Antoine; Delcros, Geoffroy; Etienne, Monique; Teixeira, Allison; Boisseau, Nathalie] Univ Clermont Auvergne, Lab AME2P, EA 3533, Clermont Ferrand, France.
   [Maillard, Florie; Vazeille, Emilie; Barnich, Nicolas; Sauvanet, Pierre] Univ Clermont Auvergne, M2iSH, UMR 1071 INSERM, UCS INRA 2018, Clermont Ferrand, France.
   [Vazeille, Emilie; Sauvanet, Pierre] Univ Clermont Auvergne, CHU Clermont Ferrand, Serv Malad Appareil Digestif, Clermont Ferrand, France.
   [Combaret, Lydie] Univ Clermont Auvergne, UMR 1019, UNH, INRA, Clermont Ferrand, France.
   [Madeuf, Elise; Pialoux, Vincent] Univ Lyon 1, Univ Lyon, LIBM EA 742, Villeurbanne, France.
   [Pialoux, Vincent] Inst Univ France, Paris, France.
   [Boisseau, Nathalie] CRNH Auvergne, Clermont Ferrand, France.
C3 Universite de Rennes; Universite Clermont Auvergne (UCA); Institut
   National de la Sante et de la Recherche Medicale (Inserm); Universite
   Clermont Auvergne (UCA); INRAE; Universite Clermont Auvergne (UCA); CHU
   Clermont Ferrand; INRAE; Universite Clermont Auvergne (UCA); Universite
   Claude Bernard Lyon 1; Institut Universitaire de France
RP Pialoux, V (corresponding author), Univ Lyon 1, Univ Lyon, LIBM EA 742, Villeurbanne, France.; Pialoux, V (corresponding author), Inst Univ France, Paris, France.
EM vincent.pialoux@univ-lyon1.fr
FU "Region AuvergneRhone-Alpes" (PREVAMIC project); French government
   IDEX-ISITE initiative [16-IDEX-0001 (CAP 20-25)]; I-SITE project of the
   University of Clermont Auvergne [CAP 2025]; INSERM (U1071); INRA
   (USC-2018); Association F. Aupetit (AFA)
FX This study was supported by (i) the "Region AuvergneRhone-Alpes"
   (PREVAMIC project), (ii) the French government IDEX-ISITE initiative
   16-IDEX-0001 (CAP 20-25) and I-SITE project (CAP 2025) of the University
   of Clermont Auvergne, (iii) INSERM (U1071) and INRA (USC-2018), and (iv)
   grants from the Association F. Aupetit (AFA).
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NR 70
TC 27
Z9 31
U1 2
U2 9
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PD JUL 14
PY 2019
VL 2019
AR 1965364
DI 10.1155/2019/1965364
PG 11
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA IM2VB
UT WOS:000477848900001
OA Green Submitted, Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Sampath, H
   Batra, AK
   Vartanian, V
   Carmical, JR
   Prusak, D
   King, IB
   Lowell, B
   Earley, LF
   Wood, TG
   Marks, DL
   McCullough, AK
   Lloyd, RS
AF Sampath, Harini
   Batra, Ayesha K.
   Vartanian, Vladimir
   Carmical, J. Russ
   Prusak, Deborah
   King, Irena B.
   Lowell, Brian
   Earley, Lauriel F.
   Wood, Thomas G.
   Marks, Daniel L.
   McCullough, Amanda K.
   Lloyd, R. Stephen
TI Variable penetrance of metabolic phenotypes and development of high-fat
   diet-induced adiposity in NEIL1-deficient mice
SO AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
LA English
DT Article
DE nei-like 1; oxidative stress; base excision repair; metabolic syndrome;
   mitochondrial DNA
ID MITOCHONDRIAL-DNA DELETIONS; OXIDATIVELY DAMAGED DNA;
   BASE-EXCISION-REPAIR; INSULIN-RESISTANCE; NEIL1 DNA; GENE-EXPRESSION;
   HUMAN-DISEASE; COPY NUMBER; GLYCOSYLASE; OBESITY
AB Sampath H, Batra AK, Vartanian V, Carmical JR, Prusak D, King IB, Lowell B, Earley LF, Wood TG, Marks DL, McCullough AK, Lloyd RS. Variable penetrance of metabolic phenotypes and development of high-fat diet-induced adiposity in NEIL1-deficient mice. Am J Physiol Endocrinol Metab 300: E724-E734, 2011. First published February 1, 2011; doi: 10.1152/ajpendo. 00387.2010.-Exposure to chronic and acute oxidative stress is correlated with many human diseases, including, but not limited to, cancer, heart disease, diabetes, and obesity. In addition to cellular lipids and proteins, cellular oxidative stress can result in damage to DNA bases, especially in mitochondrial DNA. We previously described the development of spontaneous late-onset obesity, hepatic steatosis, hyperinsulinemia, and hyperleptinemia in mice that are deficient in the DNA glycosylase nei-like 1 (NEIL1), which initiates base excision repair of several oxidatively damaged bases. In the current study, we report that exposure to a chronic oxidative stress in the form of a high-fat diet greatly accelerates the development of obesity in neil1(-/-) mice. Following a 5-wk high-fat diet challenge, neil1(-/-) mice gained significantly more body weight than neil1(-/-) littermates and had increased body fat accumulation and moderate to severe hepatic steatosis. Analysis of oxygen consumption by indirect calorimetry indicated a modest reduction in total oxygen consumption in neil1(-/-) mice that was abolished upon correction for lean body mass. Additionally, hepatic expression of several inflammatory genes was significantly upregulated in neil1(-/-) mice following high-fat diet challenge compared with chow-fed or neil1(-/-) counterparts. A long-term high-fat diet also induced glucose intolerance as well as a significant reduction in mitochondrial DNA and protein content in neil1(-/-) mice. Collectively, these data indicate that NEIL1 deficiency results in an increased susceptibility to obesity and related complications potentially by lowering the threshold for tolerance of cellular oxidative stress in neil1(-/-) mice.
C1 [Sampath, Harini; Vartanian, Vladimir; Lowell, Brian; Earley, Lauriel F.; McCullough, Amanda K.; Lloyd, R. Stephen] Oregon Hlth & Sci Univ, Dept Mol & Med Genet, Ctr Res Occupat & Environm Toxicol, Portland, OR 97239 USA.
   [Batra, Ayesha K.; Marks, Daniel L.] Oregon Hlth & Sci Univ, Dept Pediat, Portland, OR 97239 USA.
   [Carmical, J. Russ; Prusak, Deborah; Wood, Thomas G.] Univ Texas Med Branch, Dept Biochem & Mol Biol, Galveston, TX USA.
   [King, Irena B.] Univ New Mexico, Div Epidemiol, Albuquerque, NM 87131 USA.
C3 Oregon Health & Science University; Oregon Health & Science University;
   University of Texas System; University of Texas Medical Branch
   Galveston; University of New Mexico
RP Lloyd, RS (corresponding author), Oregon Hlth & Sci Univ, Dept Mol & Med Genet, Ctr Res Occupat & Environm Toxicol, 3181 SW Sam Jackson Pk Rd, Portland, OR 97239 USA.
EM lloydst@ohsu.edu
RI Marks, Daniel/C-3712-2009; Wood, Thomas/B-6172-2012
FU National Institute of Diabetes and Digestive and Kidney Diseases
   [RO1-DK-075974]
FX This work was supported by National Institute of Diabetes and Digestive
   and Kidney Diseases Grant RO1-DK-075974 (to R. S. Lloyd).
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NR 52
TC 45
Z9 48
U1 0
U2 3
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0193-1849
EI 1522-1555
J9 AM J PHYSIOL-ENDOC M
JI Am. J. Physiol.-Endocrinol. Metab.
PD APR
PY 2011
VL 300
IS 4
BP E724
EP E734
DI 10.1152/ajpendo.00387.2010
PG 11
WC Endocrinology & Metabolism; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Physiology
GA 741FZ
UT WOS:000288850600013
PM 21285402
OA Green Published
DA 2025-06-11
ER

PT J
AU Bahls, M
   Könemann, S
   Markus, MRP
   Wenzel, K
   Riedrich, NF
   Nauck, M
   Völzke, H
   Steveling, A
   Janowitz, D
   Grabe, HJ
   Felix, SB
   Dörr, M
AF Bahls, Martin
   Koenemann, Stephanie
   Markus, Marcello R. P.
   Wenzel, Kristin
   Riedrich, Nele F.
   Nauck, Matthias
   Voelzke, Henry
   Steveling, Antje
   Janowitz, Deborah
   Grabe, Hans-Joergen
   Felix, Stephan B.
   Doerr, Marcus
TI Brain-derived neurotrophic factor is related with adverse cardiac
   remodeling and high NTproBNP
SO SCIENTIFIC REPORTS
LA English
DT Article
ID LEFT-VENTRICULAR HYPERTROPHY; METABOLIC SYNDROME; PLASMA-LEVELS; BDNF;
   INFLAMMATION; EXPRESSION; DISEASE; HEALTH; ADULTS; ASSOCIATION
AB The brain-derived neurotrophic factor (BDNF) is a neuronal growth factor essential for normal cardiac contraction and relaxation. Alterations in BDNF signaling are related to the development of cardiovascular disease. Whether BDNF is related to subclinical cardiac remodeling is unclear. We related BDNF with echocardiographic parameters and NTproBNP in a large population-based cohort (n = 2,976, median age 48 years; 45% male). Transthoracic echocardiography was performed on all subjects and BDNF was measured by ELISA. Study participants with severe kidney dysfunction, previous myocardial infarction, and LV ejection fraction <40% were excluded. Linear regression models were adjusted for age, sex, lean mass, fat mass, current smoking, systolic blood pressure and depression. Low BDNF was associated with high NTproBNP. A 10,000 pg/ml lower BDNF was related with a 2.5 g higher (95%-confidence interval [CI]: 0.2 to 4.9; p = 0.036) LV mass, 0.01 cm posterior wall thickness (0.003 to 0.022; p = 0.007) and 0.02 E/A ratio (0.003 to 0.042, p = 0.026). Here we show that low BDNF levels are related with adverse cardiac remodeling and higher levels of NTproBNP. Further research is warranted to assess if BDNF may be used to monitor neuronal-cardiac damage during CVD progression.
C1 [Bahls, Martin; Koenemann, Stephanie; Markus, Marcello R. P.; Wenzel, Kristin; Felix, Stephan B.; Doerr, Marcus] Univ Med Greifswald, Dept Internal Med B, Greifswald, Germany.
   [Bahls, Martin; Koenemann, Stephanie; Markus, Marcello R. P.; Wenzel, Kristin; Riedrich, Nele F.; Nauck, Matthias; Voelzke, Henry; Felix, Stephan B.; Doerr, Marcus] German Ctr Cardiovasc Res DZHK, Partner Site Greifswald, Greifswald, Germany.
   [Riedrich, Nele F.; Nauck, Matthias] Univ Med Greifswald, Inst Clin Chem & Lab Med, Greifswald, Germany.
   [Voelzke, Henry] Univ Med Greifswald, Inst Community Med, Greifswald, Germany.
   [Steveling, Antje] Univ Med Greifswald, Dept Internal Med A, Greifswald, Germany.
   [Janowitz, Deborah; Grabe, Hans-Joergen] Univ Med Greifswald, Dept Psychiat & Psychotherapy, Greifswald, Germany.
   [Grabe, Hans-Joergen] German Ctr Neurodegenerat Dis DZNE, Partner Site Greifswald, Greifswald, Germany.
C3 Universitat Greifswald; Greifswald Medical School; German Centre for
   Cardiovascular Research; Universitat Greifswald; Greifswald Medical
   School; Universitat Greifswald; Greifswald Medical School; Universitat
   Greifswald; Greifswald Medical School; Universitat Greifswald;
   Greifswald Medical School; Helmholtz Association; German Center for
   Neurodegenerative Diseases (DZNE)
RP Bahls, M (corresponding author), Univ Med Greifswald, Dept Internal Med B, Greifswald, Germany.; Bahls, M (corresponding author), German Ctr Cardiovasc Res DZHK, Partner Site Greifswald, Greifswald, Germany.
EM Martin.Bahls@uni-greifswald.de
RI Dörr, Marcus/F-1919-2010; Markus, Marcello/H-7698-2019; Bahls,
   Martin/Q-6639-2018
OI Bahls, Martin/0000-0002-2016-5852; Dorr, Marcus/0000-0001-7471-475X;
   Konemann, Stephanie/0000-0002-3396-2906; Grabe, Hans
   J/0000-0003-3684-4208
FU German Federal Ministry of Education and Research (BMBF) [01ZZ96030,
   01ZZ0701]; DZHK (German Centre for Cardiovascular Research)
FX The Study of Health in Pomerania (SHIP) is part of the Community
   Medicine Research net (CMR) (http://www.medizin.uni-greifswald.de/icm)
   of the University of Greifswald funded by grants from the German Federal
   Ministry of Education and Research (BMBF, grant 01ZZ96030, 01ZZ0701).
   This study was further supported by the DZHK (German Centre for
   Cardiovascular Research).
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NR 51
TC 35
Z9 35
U1 0
U2 2
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD OCT 28
PY 2019
VL 9
AR 15421
DI 10.1038/s41598-019-51776-8
PG 9
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA JH5TT
UT WOS:000492832300006
PM 31659205
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Weng, SW
   Chen, BC
   Wang, YC
   Liu, CK
   Sun, MF
   Chang, CM
   Lin, JG
   Yen, HR
AF Weng, Shu-Wen
   Chen, Bor-Chyuan
   Wang, Yu-Chiao
   Liu, Chun-Kai
   Sun, Mao-Feng
   Chang, Ching-Mao
   Lin, Jaung-Geng
   Yen, Hung-Rong
TI Traditional Chinese Medicine Use among Patients with Psoriasis in
   Taiwan: A Nationwide Population-Based Study
SO EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Article
ID DICTAMNUS-DASYCARPUS TURCZ.; HERBAL MEDICINE; PRESCRIPTION PATTERNS;
   CONTACT-DERMATITIS; ATOPIC-DERMATITIS; ROOT BARK; THERAPY; RISK;
   EFFICACY; COMPLEMENTARY
AB Traditional Chinese medicine (TCM) has long been used for patients with psoriasis. This study aimed to investigate TCM usage in patients with psoriasis. We analyzed a cohort of one million individuals representing the 23 million enrollees randomly selected from the National Health Insurance Research Database in Taiwan. We identified 28,510 patients newly diagnosed with psoriasis between 2000 and 2010. Among them, 20,084 (70.4%) patients were TCM users. Patients who were female, younger, white-collar workers and lived in urbanized area tended to be TCM users. The median interval between the initial diagnosis of psoriasis to the first TCM consultation was 12 months. More than half (N = 11,609; 57.8%) of the TCM users received only Chinese herbal medicine. Win-qing-yin and Bai-xian-pi were the most commonly prescribed Chinese herbal formula and single herb, respectively. The core prescription pattern comprised Mu-dan-pi, Wen-qing-yin, Zi-cao, Bai-xian-pi, and Di-fu-zi. Patients preferred TCM than Western medicine consultations when they had metabolic syndrome, hepatitis, rheumatoid arthritis, alopecia areata, Crohn's disease, cancer, depression, fatty liver, chronic airway obstruction, sleep disorder, and allergic rhinitis. In conclusion, TCM use is popular among patients with psoriasis in Taiwan. Future clinical trials to investigate its efficacy are warranted.
C1 [Weng, Shu-Wen; Sun, Mao-Feng; Lin, Jaung-Geng; Yen, Hung-Rong] China Med Univ, Grad Inst Chinese Med, Coll Chinese Med, Taichung, Taiwan.
   [Weng, Shu-Wen] Minist Hlth & Welf, Taichung Hosp, Dept Chinese Med, Taichung, Taiwan.
   [Chen, Bor-Chyuan] Buddhist Tzu Chi Med Fdn, Dalin Tzu Chi Hosp, Dept Chinese Med, Chiayi, Taiwan.
   [Wang, Yu-Chiao] China Med Univ Hosp, Management Off Hlth Data, Taichung, Taiwan.
   [Liu, Chun-Kai; Sun, Mao-Feng; Yen, Hung-Rong] China Med Univ Hosp, Dept Chinese Med, Taichung, Taiwan.
   [Sun, Mao-Feng; Lin, Jaung-Geng; Yen, Hung-Rong] China Med Univ, Sch Chinese Med, Coll Chinese Med, Taichung, Taiwan.
   [Sun, Mao-Feng; Yen, Hung-Rong] China Med Univ, Res Ctr Chinese Med & Acupuncture, Taichung, Taiwan.
   [Chang, Ching-Mao] Taipei Vet Gen Hosp, Ctr Tradit Med, Taipei, Taiwan.
   [Chang, Ching-Mao] Chang Gung Univ, Grad Inst Clin Med, Coll Med, Taoyuan, Taiwan.
   [Chang, Ching-Mao] Chang Gung Univ, Grad Inst Tradit Chinese Med, Coll Med, Taoyuan, Taiwan.
   [Yen, Hung-Rong] China Med Univ Hosp, Dept Med Res, Res Ctr Tradit Chinese Med, Taichung, Taiwan.
C3 China Medical University Taiwan; Buddhist Tzu Chi General Hospital;
   Dalin Tzu Chi Hospital; China Medical University Taiwan; China Medical
   University Hospital - Taiwan; China Medical University Taiwan; China
   Medical University Hospital - Taiwan; China Medical University Taiwan;
   China Medical University Taiwan; Taipei Veterans General Hospital; Chang
   Gung University; Chang Gung University; China Medical University Taiwan;
   China Medical University Hospital - Taiwan
RP Lin, JG; Yen, HR (corresponding author), China Med Univ, Grad Inst Chinese Med, Coll Chinese Med, Taichung, Taiwan.; Yen, HR (corresponding author), China Med Univ Hosp, Dept Chinese Med, Taichung, Taiwan.; Lin, JG; Yen, HR (corresponding author), China Med Univ, Sch Chinese Med, Coll Chinese Med, Taichung, Taiwan.; Yen, HR (corresponding author), China Med Univ, Res Ctr Chinese Med & Acupuncture, Taichung, Taiwan.; Yen, HR (corresponding author), China Med Univ Hosp, Dept Med Res, Res Ctr Tradit Chinese Med, Taichung, Taiwan.
EM jglin@mail.cmu.edu.tw; hungrongyen@gmail.com
RI Wang, Ying-Chiao/U-8210-2017; Yen, Jui-Hung/AAV-3455-2020; Chang,
   Yu-Chan/W-3582-2019; Chun-Kai, Liu/AAJ-2091-2020; Yen,
   Hung-Rong/M-1373-2013
OI Chang, Ching-Mao/0000-0002-3853-2067; Yen,
   Hung-Rong/0000-0002-0131-1658; Sun, Mao-Feng/0000-0003-1465-0330
FU China Medical University under the Aim for Top University Plan of the
   Ministry of Education, Taiwan; Taiwan Ministry of Health and Welfare
   Clinical Trial and Research Center of Excellence
   [MOHW105-TDU-B-212-133019]
FX This study was supported by China Medical University under the Aim for
   Top University Plan of the Ministry of Education, Taiwan. This study was
   also supported in part by the Taiwan Ministry of Health and Welfare
   Clinical Trial and Research Center of Excellence
   (MOHW105-TDU-B-212-133019). This study was based in part on data from
   the National Health Insurance Research Database, provided by the
   National Health Insurance Administration, Ministry of Health and
   Welfare, and managed by National Health Research Institutes.
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NR 51
TC 32
Z9 32
U1 1
U2 18
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1741-427X
EI 1741-4288
J9 EVID-BASED COMPL ALT
JI Evid.-based Complement Altern. Med.
PY 2016
VL 2016
AR 3164105
DI 10.1155/2016/3164105
PG 13
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA EA8PY
UT WOS:000386900500001
OA hybrid, Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Gorska-Ciebiada, M
   Saryusz-Wolska, M
   Borkowska, A
   Ciebiada, M
   Loba, J
AF Gorska-Ciebiada, Malgorzata
   Saryusz-Wolska, Malgorzata
   Borkowska, Anna
   Ciebiada, Maciej
   Loba, Jerzy
TI Serum Soluble Adhesion Molecules and Markers of Systemic Inflammation in
   Elderly Diabetic Patients with Mild Cognitive Impairment and Depressive
   Symptoms
SO BIOMED RESEARCH INTERNATIONAL
LA English
DT Article
ID LATE-LIFE DEPRESSION; METABOLIC SYNDROME; E-SELECTIN; DEMENTIA; DISEASE;
   MELLITUS
AB The aim of the study was to determine the serum levels of soluble adhesion molecules and hs-CRP in elderly diabetics with mild cognitive impairment (MCI) alone or with depressive symptoms. Methods. 219 diabetics elders were screened for psychiatric disorders and divided: group 1, MCI without depressive mood; group 2, MCI with depressive mood; group 3, controls. Data of biochemical parameters and biomarkers were collected. Results. In groups 1 and 2 levels of all biomarkers were significantly higher as compared to controls. The highest level of hs-CRP and sICAM-1 was detected in group 2. SVCAM-1 and sE-selectin levels were also the highest in group 2; however they did not significantly differ as compared to group 1. MoCA score was negatively correlated with all biomarkers in group 1. The logistic regression model showed that variables which increased the likelihood of having depressive syndrome in MCI patients were older age, stroke, neuropathy, increased number of comorbidities, and higher sICAM-1 level. Conclusions. We first demonstrated that elderly diabetic patients with MCI, particularly those with depressive mood have higher levels of soluble adhesion molecules and markers of low-grade systemic inflammation. Coexisting depressive syndrome in patients with MCI through common inflammatory pathways may result in augmentation of psychiatric disorders.
C1 [Gorska-Ciebiada, Malgorzata; Saryusz-Wolska, Malgorzata; Borkowska, Anna; Loba, Jerzy] Med Univ Lodz, Dept Internal Med & Diabetol, PL-92213 Lodz, Poland.
   [Ciebiada, Maciej] Med Univ Lodz, Dept Gen & Oncol Pneumol, PL-90153 Lodz, Poland.
C3 Medical University Lodz; Medical University Lodz
RP Gorska-Ciebiada, M (corresponding author), Med Univ Lodz, Dept Internal Med & Diabetol, 251 Pomorska St, PL-92213 Lodz, Poland.
EM malgorzatagc@op.pl
RI Ciebiada, Maciej/S-9324-2016; Borkowska, Alina/G-8816-2014;
   Gorska-Ciebiada, Malgorzata/S-9668-2016
OI Gorska-Ciebiada, Malgorzata/0000-0002-0065-4376; Borkowska,
   Anna/0000-0002-8971-9868; Ciebiada, Maciej/0000-0003-3391-264X
FU Medical University of Lodz [502-03/8-072-03/502-64-052]
FX The study was supported by nonprofit grant of Medical University of Lodz
   no. 502-03/8-072-03/502-64-052.
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NR 31
TC 10
Z9 12
U1 0
U2 3
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2314-6133
EI 2314-6141
J9 BIOMED RES INT
JI Biomed Res. Int.
PY 2015
VL 2015
AR 826180
DI 10.1155/2015/826180
PG 8
WC Biotechnology & Applied Microbiology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Research & Experimental Medicine
GA CL8EV
UT WOS:000357206600001
PM 26167502
OA Green Submitted, Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Cheung, N
   Rogers, S
   Mosley, TH
   Klein, R
   Couper, D
   Wong, TY
AF Cheung, Ning
   Rogers, Sophie
   Mosley, Thomas H.
   Klein, Ronald
   Couper, David
   Wong, Tien Y.
TI Vital Exhaustion and Retinal Microvascular Changes in Cardiovascular
   Disease: Atherosclerosis Risk in Communities Study
SO PSYCHOSOMATIC MEDICINE
LA English
DT Article
DE vital exhaustion; depression; microvascular disease; cardiovascular
   disease; retinopathy; retinal vascular caliber
ID CORONARY-HEART-DISEASE; DIABETIC-RETINOPATHY; ISCHEMIC-STROKE; OCULAR
   NEOVASCULARIZATION; MYOCARDIAL-INFARCTION; PSYCHOLOGICAL-FACTORS;
   SYNDROME-X; MORTALITY; ABNORMALITIES; ASSOCIATION
AB Objective: To determine if vital exhaustion, a measure of negative emotion, is associated with microvascular changes in the retina. Negative psychological factors, such as depression, have been implicated in the development of cardiovascular disease. Whether this link is mediated by macrovascular or microvascular disease is unknown. Methods: We performed a population-based, cross-sectional study of 10,364 White and African Americans aged 48 to 73 years. Vital exhaustion scores were determined from the Maastricht questionnaire and categorized into quartiles. Retinopathy signs and retinal vascular caliber were graded from retinal photographs following standardized protocols. Results: After adjusting for age, gender, race, study center, education, smoking, blood pressure, diabetes, and other risk factors, higher vital exhaustion scores (highest versus lowest quartiles) were associated modestly with the presence of retinopathy (odds ratio [OR]=1.27; 95% Confidence Interval [CI]=1.01-1.59), particularly retinal hemorrhages (OR=1.711-95% CI=1.20-2.44), and with generalized retinal venular widening (OR=1.191-95% CI=1.03-1.38). Analyzing vital exhaustion as a continuous variable did not change the pattern of the associations. Conclusions: Middle-aged people with vital exhaustion may be more likely to have retinopathy signs that have been identified as risk predictors of cardiovascular events. Further research is needed to explore the possible adverse effects of negative emotion on the microcirculation.
C1 [Cheung, Ning; Rogers, Sophie; Wong, Tien Y.] Univ Melbourne, Ctr Eye Res Australia, Melbourne, Vic 3002, Australia.
   [Mosley, Thomas H.] Univ Mississippi, Med Ctr, Dept Med, Jackson, MS 39216 USA.
   [Klein, Ronald] Univ Wisconsin, Dept Ophthalmol, Madison, WI USA.
   [Couper, David] Univ N Carolina, Dept Biostat, Chapel Hill, NC USA.
   [Wong, Tien Y.] Natl Univ Singapore, Singapore Eye Res Inst, Singapore 117548, Singapore.
C3 Centre for Eye Research Australia; University of Melbourne; University
   of Mississippi Medical Center; University of Mississippi; University of
   Wisconsin System; University of Wisconsin Madison; University of North
   Carolina; University of North Carolina Chapel Hill; National University
   of Singapore; Singapore National Eye Center
RP Wong, TY (corresponding author), Univ Melbourne, Ctr Eye Res Australia, 32 Gisborne St, Melbourne, Vic 3002, Australia.
EM twong@unimelb.edu.au
RI Cheung, Ning/F-2043-2013; Wong, Tien Y/AAC-9724-2020
OI Klein, Ronald/0000-0002-4428-6237; Couper, David/0000-0002-4313-9235;
   Wong, Tien Y/0000-0002-8448-1264
FU National Heart, Lung, and Blood Institute [N01-HC-55015, N01-HC-55016,
   N01-HC-55018, N01-HC-55019, N01-HC-55020, N01-HC-55021, N01-HC-55022];
   Alcon Research Institute Award; Sylvia and Charles Viertel Clinical
   Investigator Award
FX The Atherosclerosis Risk in Communities study is carried out as a
   collaborative study supported by National Heart, Lung, and Blood
   Institute Contracts N01-HC-55015, N01-HC-55016, N01-HC-55018,
   N01-HC-55019, N01-HC-55020, N01-HC-55021, and N01-HC-55022. Additional
   support was provided by the Alcon Research Institute Award and the
   Sylvia and Charles Viertel Clinical Investigator Award (T.Y.W.).
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NR 47
TC 15
Z9 15
U1 0
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0033-3174
J9 PSYCHOSOM MED
JI Psychosom. Med.
PD APR
PY 2009
VL 71
IS 3
BP 308
EP 312
DI 10.1097/PSY.0b013e318190f009
PG 5
WC Psychiatry; Psychology; Psychology, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry; Psychology
GA 434NQ
UT WOS:000265281800009
PM 19073748
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Bazar, KA
   Yun, AJ
   Lee, PY
   Daniel, SM
   Doux, JD
AF Bazar, KA
   Yun, AJ
   Lee, PY
   Daniel, SM
   Doux, JD
TI Obesity and ADHD may represent different manifestations of a common
   environmental oversampling syndrome: a model for revealing mechanistic
   overlap among cognitive, metabolic, and inflammatory disorders
SO MEDICAL HYPOTHESES
LA English
DT Article
ID ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; LONG-TERM POTENTIATION;
   BEHAVIORAL TREATMENT; LIFE-SPAN; ASSOCIATION; EXPOSURE; CHILDREN;
   INSULIN; HEALTH; REWARD
AB Obesity and attention-deficit hyperactivity disorder (ADHD) are both increasing in prevalence. Childhood exposure to television has shown linkage to both AND and obesity with the former ascribed to dysfunctional cognitive hyperstimutation and the tatter to altered patterns of diet and exercise. Empirical evidence has contradicted prior presumptions that the hyperactivity of AND would decrease the risk of obesity. Instead, obesity and AND demonstrate significant comorbidity. We propose that obesity and AND represent different manifestations of the same underlying dysfunction, a phenomenon we term environmental oversampling syndrome. Oversupply of information in the form of nutritional content and sensory content may independently predispose to both obesity and ADHD. Moreover, the pathogenic mechanisms of these conditions may overlap such that nutritional excess contributes to AND and cognitive hyperstimulation contributes to obesity. The overlapping effects of medications provide further evidence towards the existence of shared etiologic pathways. Metabolism and cognition may represent parallel systems of intelligence, and oversampling of content may constitute the source of parallel dysfunctions. The emerging association between psychiatric and metabolic disorders suggests a fundamental biologic link between these two systems. In addition, the immune system may represent yet another form of intelligence. The designation of syndrome X subsumes seemingly unrelated metabolic and inflammatory entities. Environmental oversampling syndrome may represent an even more inclusive concept that encompasses various metabolic, inflammatory, and behavioral conditions. Apparently disparate conditions such as insulin resistance, diabetes, hypertension, syndrome X, obesity, AND, depression, psychosis, steep apnea, inflammation, autism, and schizophrenia may operate through common pathways, and treatments used exclusively for one of these conditions may prove beneficial for the others. (c) 2005 Elsevier Ltd. All rights reserved.
C1 San Mateo Med Ctr, Dept Dermatol, Palo Alto, CA 94301 USA.
   Stanford Univ, Stanford, CA 94305 USA.
   Univ Calif San Francisco, San Francisco, CA 94143 USA.
C3 Stanford University; University of California System; University of
   California San Francisco
RP San Mateo Med Ctr, Dept Dermatol, 987 Addison Ave, Palo Alto, CA 94301 USA.
EM kbazar@sbcglobal.net
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NR 67
TC 51
Z9 57
U1 0
U2 19
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0306-9877
EI 1532-2777
J9 MED HYPOTHESES
JI Med. Hypotheses
PY 2006
VL 66
IS 2
BP 263
EP 269
DI 10.1016/j.mehy.2005.02.042
PG 7
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Research & Experimental Medicine
GA 002WS
UT WOS:000234643400006
PM 15905045
DA 2025-06-11
ER

PT J
AU Barlovic, DP
   Harjutsalo, V
   Groop, PH
AF Barlovic, Drazenka Pongrac
   Harjutsalo, Valma
   Groop, Per-Henrik
TI Exercise and nutrition in type 1 diabetes: Insights from the FinnDiane
   cohort
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Review
DE type 1 diabetes; physical activity; diet; depression; complications;
   review
ID TIME PHYSICAL-ACTIVITY; ACTIVITY REDUCES RISK; ALL-CAUSE MORTALITY;
   CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; GLYCEMIC CONTROL;
   SELF-MANAGEMENT; ASSOCIATION; ENDOTOXEMIA; NEPHROPATHY
AB Type 1 diabetes is a challenging disease, characterized by dynamic changes in the insulin need during life periods, seasons of the year, but also by everyday situations. In particular, changes in insulin need are evident before, during and after exercise and having meals. In the midst of different life demands, it can be very burdensome to achieve tight glycemic control to prevent late diabetes complications, and at the same time, to avoid hypoglycemia. Consequently, many individuals with type 1 diabetes are faced with diabetes distress, decreasing profoundly their quality of life. Today, the nationwide Finnish Diabetic Nephropathy (FinnDiane) Study, launched in 1997, has gathered data from more than 8,000 well-characterized individuals with type 1 diabetes, recruited from 93 centers all over Finland and has established its position as the world's leading project on studying complications in individuals with type 1 diabetes. Studying risk factors and mechanisms of diabetes complications is inconceivable without trying to understand the effects of exercise and nutrition on glycemic control and the development of diabetes complications. Therefore, in this paper we provide findings regarding food and exercise, accumulated during the 25 years of studying lives of Finnish people with type 1 diabetes.
C1 [Barlovic, Drazenka Pongrac] Univ Med Ctr Ljubljana, Dept Endocrinol Diabet & Metab Dis, Ljubljana, Slovenia.
   [Barlovic, Drazenka Pongrac] Univ Ljubljana, Fac Med, Ljubljana, Slovenia.
   [Harjutsalo, Valma; Groop, Per-Henrik] Folkhalsan Res Ctr, Folkhalsan Inst Genet, Helsinki, Finland.
   [Groop, Per-Henrik] Univ Helsinki, Helsinki Univ Cent Hosp, Dept Nephrol, Helsinki, Finland.
   [Groop, Per-Henrik] Univ Helsinki, Fac Med, Res Program Clin & Mol Metab, Helsinki, Finland.
   [Groop, Per-Henrik] Monash Univ, Cent Clin Sch, Dept Diabet, Melbourne, Vic, Australia.
C3 University Medical Centre Ljubljana; University of Ljubljana; Folkhalsan
   Research Center; University of Helsinki; Helsinki University Central
   Hospital; University of Helsinki; Monash University
RP Groop, PH (corresponding author), Folkhalsan Res Ctr, Folkhalsan Inst Genet, Helsinki, Finland.; Groop, PH (corresponding author), Univ Helsinki, Helsinki Univ Cent Hosp, Dept Nephrol, Helsinki, Finland.; Groop, PH (corresponding author), Univ Helsinki, Fac Med, Res Program Clin & Mol Metab, Helsinki, Finland.; Groop, PH (corresponding author), Monash Univ, Cent Clin Sch, Dept Diabet, Melbourne, Vic, Australia.
EM per-henrik.groop@helsinki.fi
RI Harjutsalo, Valma/AAL-6588-2021
OI Groop, Per-Henrik/0000-0003-4055-6954
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NR 54
TC 13
Z9 13
U1 1
U2 12
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD DEC 22
PY 2022
VL 13
AR 1064185
DI 10.3389/fendo.2022.1064185
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 7N3SW
UT WOS:000907263800001
PM 36619534
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Sekine, A
   Hozumi, S
   Shimizu, T
AF Sekine, Atsushi
   Hozumi, Satoshi
   Shimizu, Tetsuo
TI Influence of painful physical symptoms in the treatment of Japanese
   patients with melancholic major depressive disorder: A prospective
   cohort study
SO PSYCHIATRY RESEARCH
LA English
DT Article
DE Melancholic features; Ethnicity; Serotonin-noradrenalin reuptake
   inhibitors; Duloxetine
ID METABOLIC SYNDROME; ASIAN PATIENTS; ASSOCIATION; OUTCOMES; COMORBIDITY;
   PREVALENCE; DULOXETINE; FREQUENCY
AB The aim of this study was to clarify how painful physical symptoms affect treatment outcomes in patients with melancholic major depressive disorder. The subjects comprised 100 consecutive Japanese outpatients with melancholic major depressive disorder who visited our clinic from October 2011 to October 2014. All subjects were interviewed for Diagnostic and Statistical Manual of Mental Disorders Axis 2, 3, and 4 and family history of major depressive disorder, and then grouped according to the presence of painful physical symptoms. We evaluated painful physical symptoms at baseline and after 12, 24, and 36 weeks of treatment and scores on the 17-item Hamilton Rating Scale for Depression, compared major depressive disorder remission between groups, and assessed responsiveness to antidepressants. The group with painful physical symptoms had a significantly more positive family history of major depressive disorder. The major depressive disorder remission rate was high in both groups, and no significant differences were observed. However, a significant relationship between major depressive disorder and painful physical symptoms remission was observed in the group with painful physical symptoms. A significantly higher number of remitted patients with painful physical symptoms (N=61) were administered serotonin noradrenaline reuptake inhibitors, with significantly more receiving duloxetine than milnacipran. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
C1 [Sekine, Atsushi] Kei Mental Clin, Med Fdn Keishin Kai, Omagari Torimachi 10-8, Daisen City, Akita 0140027, Japan.
   [Hozumi, Satoshi] Kyowa Hosp, Med Fdn Keishin Kai, Daisen City, Akita, Japan.
   [Shimizu, Tetsuo] Akita Univ, Grad Sch Med, Dept Psychiat, Akita, Akita, Japan.
C3 Akita University
RP Sekine, A (corresponding author), Kei Mental Clin, Med Fdn Keishin Kai, Omagari Torimachi 10-8, Daisen City, Akita 0140027, Japan.
EM sekinedjs1209@xqh.biglobe.ne.jp
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NR 28
TC 3
Z9 3
U1 0
U2 11
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0165-1781
J9 PSYCHIAT RES
JI Psychiatry Res.
PD AUG 30
PY 2016
VL 242
BP 240
EP 244
DI 10.1016/j.psychres.2016.05.053
PG 5
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA DT9TC
UT WOS:000381844200038
PM 27294798
DA 2025-06-11
ER

PT J
AU Pivonello, R
   Isidori, AM
   De Martino, MC
   Newell-Price, J
   Biller, BMK
   Colao, A
AF Pivonello, Rosario
   Isidori, Andrea M.
   De Martino, Maria Cristina
   Newell-Price, John
   Biller, Beverly M. K.
   Colao, Annamaria
TI Complications of Cushing's syndrome: state of the art
SO LANCET DIABETES & ENDOCRINOLOGY
LA English
DT Review
ID BONE-MINERAL DENSITY; GLUCOCORTICOID-INDUCED OSTEOPOROSIS; AUTOIMMUNE
   THYROID-DYSFUNCTION; POLYCYSTIC OVARIAN SYNDROME; ECTOPIC
   ACTH-SECRETION; CARDIOVASCULAR RISK; DIABETES-MELLITUS; BLOOD-PRESSURE;
   SURGICAL CURE; TRANSSPHENOIDAL SURGERY
AB Cushing's syndrome is a serious endocrine disease caused by chronic, autonomous, and excessive secretion of cortisol. The syndrome is associated with increased mortality and impaired quality of life because of the occurrence of comorbidities. These clinical complications include metabolic syndrome, consisting of systemic arterial hypertension, visceral obesity, impairment of glucose metabolism, and dyslipidaemia; musculoskeletal disorders, such as myopathy, osteoporosis, and skeletal fractures; neuropsychiatric disorders, such as impairment of cognitive function, depression, or mania; impairment of reproductive and sexual function; and dermatological manifestations, mainly represented by acne, hirsutism, and alopecia. Hypertension in patients with Cushing's syndrome has a multifactorial pathogenesis and contributes to the increased risk for myocardial infarction, cardiac failure, or stroke, which are the most common causes of death; risks of these outcomes are exacerbated by a prothrombotic diathesis and hypokalaemia. Neuropsychiatric disorders can be responsible for suicide. Immune disorders are common; immunosuppression during active disease causes susceptibility to infections, possibly complicated by sepsis, an important cause of death, whereas immune rebound after disease remission can exacerbate underlying autoimmune diseases. Prompt treatment of cortisol excess and specific treatments of comorbidities are crucial to prevent serious clinical complications and reduce the mortality associated with Cushing's syndrome.
C1 [Pivonello, Rosario; De Martino, Maria Cristina; Colao, Annamaria] Univ Naples Federico II, Sez Endocrinol, Dipartimento Med Clin & Chirurg, I-80131 Naples, Italy.
   [Isidori, Andrea M.] Univ Roma La Sapienza, Dept Expt Med, Rome, Italy.
   [Newell-Price, John] Univ Sheffield, Sch Med, Dept Oncol & Metab, Sheffield, S Yorkshire, England.
   [Newell-Price, John] Sheffield Teaching Hosp NHS Fdn Trust, Royal Hallamshire Hosp, Endocrine Unit, Sheffield, S Yorkshire, England.
   [Biller, Beverly M. K.] Massachusetts Gen Hosp, Harvard Med Sch, Neuroendocrine Unit, Dept Med, Boston, MA 02114 USA.
C3 University of Naples Federico II; Sapienza University Rome; University
   of Sheffield; University of Sheffield; Harvard University; Harvard
   University Medical Affiliates; Massachusetts General Hospital; Harvard
   Medical School
RP Pivonello, R (corresponding author), Univ Naples Federico II, Sez Endocrinol, Dipartimento Med Clin & Chirurg, I-80131 Naples, Italy.
EM rosario.pivonello@unina.it
RI Colao, Annamaria/A-7671-2011; Isidori, Andrea/F-3062-2010; De Martino,
   Maria/AAJ-2234-2021
OI Isidori, Andrea/0000-0002-9037-5417
FU Novartis; Pfizer; HRA Pharma; ViroPharma-Shire; Italfarmaco; Ipsen;
   Ferring; Menarini; Otsuka; Cortendo; Lilly; Novo Nordisk
FX RP reports grants, personal fees, and other from Novartis; grants and
   personal fees from Pfizer; grants from HRA Pharma; grants and personal
   fees from ViroPharma-Shire; personal fees from Italfarmaco; personal
   fees from Ipsen; and personal fees from Ferring, outside the submitted
   work. AMI reports personal fees from Menarini, personal fees from
   Otsuka, grants and personal fees from Viropharma-Shire, and personal
   fees from Novartis, outside the submitted work. JN-P reports grants and
   personal fees from HRA Pharma, grants and personal fees from Novartis,
   and grants and personal fees from Ipsen, outside the submitted work.
   BMKB reports grants and personal fees from Cortendo, grants and personal
   fees from Novartis, personal fees from HRA Pharma, and personal fees
   from Ipsen, outside the submitted work. AC reports grants, personal
   fees, and other from Novartis; grants and personal fees from Pfizer;
   grants from HRA Pharma; grants and personal fees from Italfarmaco;
   grants, personal fees, and other from Ipsen; and grants from Ferring,
   Lilly, and Novo Nordisk, outside the submitted work. MCDM declares no
   competing interests.
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NR 155
TC 416
Z9 439
U1 7
U2 90
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 2213-8587
EI 2213-8595
J9 LANCET DIABETES ENDO
JI Lancet Diabetes Endocrinol.
PD JUL
PY 2016
VL 4
IS 7
BP 611
EP 629
DI 10.1016/S2213-8587(16)00086-3
PG 19
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA DQ0CD
UT WOS:000378864700023
PM 27177728
OA Green Submitted
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Case, A
   Menendez, A
AF Case, Anne
   Menendez, Alicia
TI Sex differences in obesity rates in poor countries: Evidence from South
   Africa
SO ECONOMICS & HUMAN BIOLOGY
LA English
DT Article
DE Sex differences; Obesity; Southern Africa
ID DEVELOPMENTAL ORIGINS; METABOLIC SYNDROME; MIDDLE-AGE; BODY-SIZE;
   NUTRITION; EPIDEMIC; FAMINE; HEALTH; RESTRICTION; GESTATION
AB Globally, men and women face markedly different risks of obesity. In all but of handful of (primarily Western European) countries, obesity is much more prevalent among women than men. We examine several potential explanations for this phenomenon. We analyze differences between men and women in reports and effects of potential underlying causes of obesity-childhood and adult poverty, depression, and attitudes about obesity. We evaluate the evidence for each explanation using data collected in an urban African township in the Cape Town metropolitan area. Three factors explain the greater obesity rates we find among women. Women who were nutritionally deprived as children are significantly more likely to be obese as adults, while men who were deprived as children face no greater risk. In addition, women of higher adult socioeconomic status are significantly more likely to be obese, which is not true for men. These two factors childhood circumstances and adult SES - can fully explain the difference in obesity rates between men and women that we find in our sample. More speculatively, in South Africa, women's perceptions of an 'ideal' female body are larger than men's perceptions of the 'ideal' male body, and individuals with larger 'ideal' body images are significantly more likely to be obese. (c) 2009 Elsevier B.V. All rights reserved.
C1 [Case, Anne] Princeton Univ, Res Program Dev Studies, Princeton, NJ 08544 USA.
   [Menendez, Alicia] Univ Chicago, Harris Sch Publ Policy, Chicago, IL 60637 USA.
C3 Princeton University; University of Chicago
RP Case, A (corresponding author), Princeton Univ, Res Program Dev Studies, Princeton, NJ 08544 USA.
EM accase@princeton.edu
FU National Institute on Aging [R01 AG20275-01, P01 AG05842-14, P30
   AG024361]
FX This research has been supported by grants from the National Institute
   on Aging (R01 AG20275-01, P01 AGO5842-14, and P30 AG024361).
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NR 38
TC 104
Z9 114
U1 0
U2 34
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1570-677X
EI 1873-6130
J9 ECON HUM BIOL
JI Econ. Hum. Biol.
PD DEC
PY 2009
VL 7
IS 3
BP 271
EP 282
DI 10.1016/j.ehb.2009.07.002
PG 12
WC Economics; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Business & Economics; Public, Environmental & Occupational Health
GA 523WO
UT WOS:000272105700001
PM 19664973
OA Green Accepted, Green Published
DA 2025-06-11
ER

PT J
AU Castrogiovanni, S
   Soreca, I
   Troiani, D
   Mauri, M
AF Castrogiovanni, Silvia
   Soreca, Isabella
   Troiani, Daniela
   Mauri, Mauro
TI Binge eating, weight gain and psychosocial adjustment in patients with
   bipolar disorder
SO PSYCHIATRY RESEARCH
LA English
DT Article
DE Mood disorders; Eating disorders; BMI; Self-esteem
ID METABOLIC SYNDROME; FOLLOW-UP; OBESITY; COMORBIDITY; ASSOCIATION;
   DEPRESSION; SYMPTOMS; COHORT
AB Binge Eating (BE) is a common eating pattern in patients with Bipolar Disorder (BD). BE may confer an increased risk for obesity, morbidity, mortality and poorer quality of life. We assessed the presence of BE and its impact on body weight, body image and self-esteem in 50 patients with BD and 50 age- and gender-matched controls. The presence and severity of BE was assessed with the Binge Eating Scale (BES). The Body Image and Self-Esteem Evaluation Scale (B-WISE) was used to assess the psychosocial impact of weight gain. Body Mass Index (BMI) was calculated. Nine (18%) patients had a score >27, indicating a likely diagnosis of BE. None of the control subjects had a BES score > 17. No association between BES score and the medications was found. Patients had a significantly higher BES score, significantly higher BMI, waist circumference and fasting blood glucose. Although the B-Wise score was higher in the controls, the difference was not statistically significant. This study suggests that BE is prevalent in patients with BD. The presence of BE eating is a predictor of higher BMI, indicating that the disruption of eating behavior may be a pathway to weight gain. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
C1 [Soreca, Isabella] Univ Pittsburgh, Sch Med, Western Psychiat Inst & Clin, Pittsburgh, PA 15213 USA.
   [Castrogiovanni, Silvia; Troiani, Daniela; Mauri, Mauro] Univ Pisa, Sch Med, Dept Psychiat Neurobiol Pharmacol & Biotechnol, I-56100 Pisa, Italy.
   [Soreca, Isabella] Univ Siena, Dept Neurosci, Sch Appl Neurol Sci, I-53100 Siena, Italy.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE); University
   of Pittsburgh; Western Psychiatric Institute & Clinic of UPMC;
   University of Pisa; University of Siena
RP Soreca, I (corresponding author), Univ Pittsburgh, Sch Med, Western Psychiat Inst & Clin, Room BT 807A,3811 OHara St, Pittsburgh, PA 15213 USA.
EM sorecai@upmc.edu
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NR 27
TC 7
Z9 7
U1 0
U2 4
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0165-1781
J9 PSYCHIAT RES
JI Psychiatry Res.
PD AUG 30
PY 2009
VL 169
IS 1
BP 88
EP 90
DI 10.1016/j.psychres.2008.06.016
PG 3
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 489QW
UT WOS:000269437600017
PM 19625088
DA 2025-06-11
ER

PT J
AU Dziegielewska-Gesiak, S
   Stoltny, D
   Brozek, A
   Muc-Wierzgon, M
   Wysocka, E
AF Dziegielewska-Gesiak, Sylwia
   Stoltny, Dorota
   Brozek, Alicja
   Muc-Wierzgon, Malgorzata
   Wysocka, Ewa
TI Are insulin-resistance and oxidative stress cause or consequence of
   aging
SO EXPERIMENTAL BIOLOGY AND MEDICINE
LA English
DT Article
DE Aging; oxidative stress; thiobarbituric acid-reacting substances;
   superoxide dismutase; total antioxidant status; insulin resistance
ID VISCERAL ADIPOSE-TISSUE; METABOLIC SYNDROME; DIABETES-MELLITUS;
   DNA-DAMAGE; ASSOCIATION; PREVALENCE; DISEASE; IMPACT
AB Insulin resistance (IR) may be associated with oxidative stress and leads to cardiovascular disorders. Current research focuses on interplay between insulin-resistance indices and oxidant-antioxidant markers in elderly individuals with or without insulin-resistance. The assessment involved anthropometric data (weight, height, BMI, percentage of body fat (FAT)) and biochemical tests (glucose, lipids, serum insulin and plasma oxidant-antioxidant markers: Thiobarbituric Acid-Reacting Substances (TBARS), Cu,Zn-superoxide dismutase (SOD-1) and total antioxidant status). Insulin resistance index (IR) assuming a cut-off point of 0.3 allows to divides groups into: insulin sensitive group (InsS) IR < 0,3 (n = 35, median age 69.0 years) and insulin-resistant group (InsR) IR >= 0.3 (n = 51, median age 71.0 years). Lipids and antioxidant defense system markers did not differentiate the investigated groups. In the InsR elderly group, the FAT was increased (P < 0.000003) and TBARS (P = 0.008) concentration decreased in comparison with InsS group. A positive correlation for SOD-1 and total antioxidant status (P < 0.05; r = 0.434) and a negative correlation for TBARS and age (P < 0.05 with r = -0.421) were calculated in InsR individuals. In elderly individuals, oxidative stress persists irrespective of insulin-resistance status. We suggest that increased oxidative stress may be consequence of old age. An insulin action identifies those at high risk for atherosclerosis, via congruent associations with oxidative stress and extra- and intra-cellular antioxidant defense systems. Thus, we maintain that insulin-resistance is not the cause of aging. Impact statement Insulin resistance is associated with oxidative stress leading to cardiovascular diseases. However, little research has been performed examining elderly individuals with or without insulin-resistance. We demonstrate that antioxidant defense systems alone is not able to abrogate insulin action in elderly individuals at high risk for atherosclerosis, whereas the combined oxidant-antioxidant markers (thiobarbituric acid-reacting substances (TBARS), Cu,Zn-superoxide dismutase (SOD-1), and total antioxidant status (TAS)) might be more efficient and perhaps produce better clinical outcome. In fact, a decrease in oxidative stress and strong interaction between antioxidant defense can be seen only among insulin-resistant elderly individuals. This is, in our opinion, valuable information for clinicians, since insulin-resistance is considered strong cardiovascular risk factor.
C1 [Dziegielewska-Gesiak, Sylwia; Stoltny, Dorota; Muc-Wierzgon, Malgorzata] Med Univ Silesia, Dept Internal Med, PL-41902 Bytom, Poland.
   [Brozek, Alicja] Poznan Univ Med Sci, Dept Clin Biochem & Lab Med, PL-60806 Poznan, Poland.
   [Wysocka, Ewa] Poznan Univ Med Sci, Chair & Dept Lab Diagnost, PL-60569 Poznan, Poland.
C3 Medical University of Silesia; Poznan University of Medical Sciences;
   Poznan University of Medical Sciences
RP Dziegielewska-Gesiak, S (corresponding author), Med Univ Silesia, Dept Internal Med, PL-41902 Bytom, Poland.
EM sgesiak@sum.edu.pl
RI Dzięgielewska-Gesiak, Sylwia/IYS-6186-2023
OI Muc-Wierzgon, Malgorzata/0000-0001-6562-7072; Stoltny,
   Dorota/0000-0002-8740-1338; Dziegielewska-Gesiak,
   Sylwia/0000-0003-1019-5959
FU Medical University of Silesia [KNW-1-072/K/9/K]
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: This work
   was supported by the Medical University of Silesia [grant number:
   KNW-1-072/K/9/K].
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NR 39
TC 11
Z9 11
U1 0
U2 5
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1535-3702
EI 1535-3699
J9 EXP BIOL MED
JI Exp. Biol. Med.
PD AUG
PY 2020
VL 245
IS 14
BP 1260
EP 1267
AR 1535370220929621
DI 10.1177/1535370220929621
EA MAY 2020
PG 8
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA MZ6JE
UT WOS:000539464600001
PM 32469639
OA Green Published
DA 2025-06-11
ER

PT J
AU Knopp, T
   Bieler, T
   Jung, R
   Ringen, J
   Molitor, M
   Jurda, A
   Münzel, T
   Waisman, A
   Wenzel, P
   Karbach, SH
   Wild, J
AF Knopp, Tanja
   Bieler, Tabea
   Jung, Rebecca
   Ringen, Julia
   Molitor, Michael
   Jurda, Annika
   Muenzel, Thomas
   Waisman, Ari
   Wenzel, Philip
   Karbach, Susanne Helena
   Wild, Johannes
TI Effects of Dietary Protein Intake on Cutaneous and Systemic Inflammation
   in Mice with Acute Experimental Psoriasis
SO NUTRIENTS
LA English
DT Article
DE protein diet; psoriasis; inflammation; psoriasis-like skin disease;
   imiquimod
ID SKIN INFLAMMATION; ENDOTHELIAL DYSFUNCTION; ANIMAL-MODELS; RISK-FACTORS;
   WEIGHT-LOSS; ARTHRITIS; SUPEROXIDE; DERMATITIS; DEPRESSION; SEVERITY
AB Background: Psoriasis is a systemic inflammatory disorder, primarily characterized by skin plaques. It is linked to co-morbidities including cardiovascular disease and metabolic syndrome. Several studies demonstrate that dietary habits can influence psoriasis development and severity. However, the effect of different dietary protein levels on psoriasis development and severity is poorly understood. In this study, we examine the influence of dietary protein on psoriasis-like skin disease in mice. Methods: We fed male C57BL/6J mice with regular, low protein and high protein chow for 4 weeks. Afterwards, we induced psoriasis-like skin disease by topical imiquimod (IMQ)-treatment on ear and back skin. The local cutaneous and systemic inflammatory response was investigated using flow cytometry analysis, histology and quantitative rt-PCR. Results: After 5 days of IMQ-treatment, both diets reduced bodyweight in mice, whereas only the high protein diet slightly aggravated IMQ-induced skin inflammation. IMQ-treatment induced infiltration of myeloid cells, neutrophils, and monocytes/macrophages into skin and spleen independently of diet. After IMQ-treatment, circulating neutrophils and reactive oxygen species were increased in mice on low and high protein diets. Conclusion: Different dietary protein levels had no striking effect on IMQ-induced psoriasis but aggravated the systemic pro-inflammatory phenotype.
C1 [Knopp, Tanja; Bieler, Tabea; Jung, Rebecca; Ringen, Julia; Molitor, Michael; Jurda, Annika; Wenzel, Philip; Karbach, Susanne Helena; Wild, Johannes] Univ Med Ctr Mainz, Ctr Thrombosis & Hemostasis CTH, D-55131 Mainz, Germany.
   [Molitor, Michael; Muenzel, Thomas; Wenzel, Philip; Karbach, Susanne Helena; Wild, Johannes] Univ Med Ctr Mainz, Ctr Cardiol Cardiol 1, D-55131 Mainz, Germany.
   [Molitor, Michael; Muenzel, Thomas; Wenzel, Philip; Karbach, Susanne Helena; Wild, Johannes] German Ctr Cardiovasc Res DZHK, Partner Site Rhine Main, D-55131 Mainz, Germany.
   [Waisman, Ari] Univ Med Ctr Mainz, Inst Mol Med, D-55131 Mainz, Germany.
   [Waisman, Ari] Univ Med Ctr Mainz, Focus Program Translat Neurosci, D-55131 Mainz, Germany.
   [Waisman, Ari] Univ Med Ctr Mainz, Res Ctr Immunotherapy, D-55131 Mainz, Germany.
C3 Johannes Gutenberg University of Mainz; Johannes Gutenberg University of
   Mainz; German Centre for Cardiovascular Research; Johannes Gutenberg
   University of Mainz; Johannes Gutenberg University of Mainz; Johannes
   Gutenberg University of Mainz
RP Wild, J (corresponding author), Univ Med Ctr Mainz, Ctr Thrombosis & Hemostasis CTH, D-55131 Mainz, Germany.; Wild, J (corresponding author), Univ Med Ctr Mainz, Ctr Cardiol Cardiol 1, D-55131 Mainz, Germany.; Wild, J (corresponding author), German Ctr Cardiovasc Res DZHK, Partner Site Rhine Main, D-55131 Mainz, Germany.
EM tanjaknopp@uni-mainz.de; tbieler@students.uni-mainz.de;
   rebeccajung@uni-mainz.de; Julia.Ringen@unimedizin-mainz.de;
   Michael.Molitor@unimedizin-mainz.de; AnnikaKristin@gmx.de;
   tmuenzel@uni-mainz.de; waisman@uni-mainz.de; wenzelp@uni-mainz.de;
   karbasu@uni-mainz.de; johannes.wild@unimedizin-mainz.de
RI Wild, Johannes/Z-3083-2019; Wenzel, Philip/Z-1503-2019; Karbach,
   Susanne/GPC-8804-2022; Molitor, Michael/Z-1696-2019; Waisman,
   Ari/C-7383-2015; Wenzel, Philip/HIA-0033-2022; Muenzel,
   Thomas/A-2912-2014
OI Wild, Johannes/0000-0002-1446-8101; Bieler, Tabea/0000-0003-3611-9305;
   Wenzel, Philip/0000-0002-5397-2781; Muenzel, Thomas/0000-0001-5503-4150;
   Karbach, Susanne/0000-0003-4462-3747
FU Boehringer Ingelheim Foundation; German Federal Ministry for Education
   and Research [BMBF EDUV24]; University of Mainz ('Inneruniversitare
   Forschungsforderung'); German Research Foundation (DFG) [KA 4035/1-1];
   Federal Ministry of Education and Research [BMBF 01EO1503]; DFG
   [CRC/Transregio TRR156/2-246807620]
FX This study was funded by the Boehringer Ingelheim Foundation "Novel and
   neglected cardiovascular risk factors: molecular mechanisms and
   therapeutic implications" (SK, JW, PW and TM). JW was supported by the
   German Federal Ministry for Education and Research (BMBF EDUV24) and the
   University of Mainz (`Inneruniversitare Forschungsforderung'). SK was
   supported by the German Research Foundation (DFG) KA 4035/1-1. SK and PW
   received funding from the Federal Ministry of Education and Research
   (BMBF 01EO1503) related to this study. SK and AWwere supported by the
   DFG via CRC/Transregio TRR156/2-246807620.
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NR 52
TC 4
Z9 4
U1 1
U2 7
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JUN
PY 2021
VL 13
IS 6
AR 1897
DI 10.3390/nu13061897
PG 13
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA TA6XV
UT WOS:000667392200001
PM 34072973
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Cao, JQ
   Zhang, XS
   Qu, FZ
   Guo, ZH
   Zhao, YQ
AF Cao, Jiaqing
   Zhang, Xiaoshu
   Qu, Fanzhi
   Guo, Zhenghong
   Zhao, Yuqing
TI Dammarane triterpenoids for pharmaceutical use: a patent review
   (2005-2014)
SO EXPERT OPINION ON THERAPEUTIC PATENTS
LA English
DT Review
DE dammarane; Panax; side chain; triterpenoid
ID ANTITUMOR EVALUATION; CHEMICAL DIVERSITY; PANAX-GINSENG; SAPONINS
AB Introduction: Dammarane triterpenoids, the main secondary metabolites of Panax ginseng, are very important natural compounds with remarkable biological activity. They could be isolated from the plants of Panax or other genus, as well as through the modifications of certain natural products. This review is a collection of a number of patents (2005 - 2014) that describe the dammarane triterpenoids for therapeutic or preventive uses on numerous common diseases.
   Areas covered: In this review, patents from 2005 to 2014 on chemical structures and treatment of different diseases by dammarane triterpenoids have been summarized. The SciFinder and the World Intellectual Property Organisation databases have been used as main sources for the search.
   Expert opinion: In the last decade, over 90 patents concerning dammarane derivatives for pharmaceutical have been published. These types of compounds could be used as agents for prevention and treatment of various kinds of diseases, such as cancer, diabetes mellitus and metabolic syndrome, hyperlipidemia, cardiovascular and cerebrovascular disease, aging, neurodegenerative disease, bone disease, liver disease, kidney disease, gastrointestinal disease, depression-type mental illness and skin aging. Rare plants, except for Panax genus, which contain dammarane triterpenoids should be studied extensively. In addition, more dammarane triterpenoids with good biological activity, especially the aglycones possessing novel side chain, should be prepared using chemical modification. Finally, pharmacological effects of dammarane triterpenoids should be further studied.
C1 [Cao, Jiaqing; Zhang, Xiaoshu; Qu, Fanzhi; Guo, Zhenghong; Zhao, Yuqing] Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med, Shenyang 110016, Peoples R China.
   [Zhao, Yuqing] Shenyang Pharmaceut Univ, Minist Educ, Key Lab Struct Based Drug Design & Discovery, Shenyang 110016, Peoples R China.
C3 Shenyang Pharmaceutical University; Ministry of Education - China;
   Shenyang Pharmaceutical University
RP Zhao, YQ (corresponding author), Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med, Shenyang 110016, Peoples R China.
EM zyq4885@126.com
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NR 106
TC 24
Z9 25
U1 0
U2 39
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 1354-3776
EI 1744-7674
J9 EXPERT OPIN THER PAT
JI Expert Opin. Ther. Patents
PD JUL
PY 2015
VL 25
IS 7
BP 805
EP 817
DI 10.1517/13543776.2015.1038239
PG 13
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA CM5DO
UT WOS:000357707200006
PM 25892194
DA 2025-06-11
ER

PT J
AU Dalkner, N
   Bengesser, S
   Birner, A
   Rieger, A
   Seebauer, J
   Platzer, M
   Hamm, C
   Maget, A
   Queissner, R
   Pilz, R
   Fellendorf, FT
   Reininghaus, B
   Strassnig, MT
   Kapfhammer, HP
   Weiss, EM
   Reininghaus, EZ
AF Dalkner, Nina
   Bengesser, Susanne
   Birner, Armin
   Rieger, Alexandra
   Seebauer, Julia
   Platzer, Martina
   Hamm, Carlo
   Maget, Alexander
   Queissner, Robert
   Pilz, Rene
   Fellendorf, Frederike T.
   Reininghaus, Bernd
   Strassnig, Martin T.
   Kapfhammer, Hans-Peter
   Weiss, Elisabeth M.
   Reininghaus, Eva Z.
TI Body Mass Index Predicts Decline in Executive Function in Bipolar
   Disorder: Preliminary Data of a 12-Month Follow-up Study
SO NEUROPSYCHOBIOLOGY
LA English
DT Article
DE Overweight; Psychopathology; Psychiatry; Cognitive function;
   Longitudinal
ID WORKING-MEMORY CAPACITY; COGNITIVE FUNCTION; ALZHEIMERS-DISEASE;
   METABOLIC SYNDROME; VASCULAR DEMENTIA; LATE-LIFE; OBESITY; INFLAMMATION;
   METAANALYSIS; RISK
AB Introduction: Obesity and associated risk factors have been linked to cognitive decline before. Objectives: In the present study, we evaluated potential cumulative negative effects of overweight and obesity on cognitive performance in euthymic patients with bipolar disorder (BD) in a longitudinal design. Methods: Neurocognitive measures (California Verbal Learning Test, Trail Making Test [TMT] A/B, Digit-Symbol-Test, Digit-Span, d2 Test), anthropometrics (e.g., body mass index [BMI]), and clinical ratings (Hamilton Depression Scale, Young Mania Rating Scale) were collected over a 12-month observation period. Follow-up data of 38 patients with BD (mean age 40 years; 15 males, 23 females) were available. Results: High baseline BMI predicted a decrease in the patient's performance in the Digit-Span backwards task measuring working memory performance. In contrast, cognitive performance was not predicted by increases in BMI at follow-up. Normal weight bipolar patients (n = 19) improved their performance on the TMT B, measuring cognitive flexibility and executive functioning, within 1 year, while overweight bipolar patients (n = 19) showed no change in this task. Conclusions: The results suggest that overweight can predict cognitive performance changes over 12 months.
C1 [Dalkner, Nina; Bengesser, Susanne; Birner, Armin; Rieger, Alexandra; Platzer, Martina; Hamm, Carlo; Maget, Alexander; Queissner, Robert; Pilz, Rene; Fellendorf, Frederike T.; Reininghaus, Bernd; Kapfhammer, Hans-Peter; Reininghaus, Eva Z.] Med Univ Graz, Dept Psychiat & Psychotherapeut Med, Auenbruggerpl 31, AT-8036 Graz, Austria.
   [Seebauer, Julia; Weiss, Elisabeth M.] Karl Franzens Univ Graz, Dept Biol Psychol, Graz, Austria.
   [Strassnig, Martin T.] Florida Atlantic Univ, Charles E Schmidt Coll Med, Dept Integrated Med Sci, Boca Raton, FL 33431 USA.
   [Weiss, Elisabeth M.] Univ Innsbruck, Dept Psychol, Clin Psychol, Innsbruck, Austria.
C3 Medical University of Graz; University of Graz; State University System
   of Florida; Florida Atlantic University; University of Innsbruck
RP Bengesser, S (corresponding author), Med Univ Graz, Dept Psychiat & Psychotherapeut Med, Auenbruggerpl 31, AT-8036 Graz, Austria.
EM susanne.bengesser@medunigraz.at
OI Weiss, Elisabeth/0000-0003-1296-3448; Fellendorf,
   Frederike/0000-0001-7215-3848
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NR 66
TC 11
Z9 10
U1 2
U2 4
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0302-282X
EI 1423-0224
J9 NEUROPSYCHOBIOLOGY
JI Neuropsychobiology
PD JAN
PY 2021
VL 80
IS 1
BP 1
EP 11
DI 10.1159/000505784
PG 11
WC Neurosciences; Psychiatry; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry; Psychology
GA QC3XS
UT WOS:000614767900001
PM 32454501
DA 2025-06-11
ER

PT J
AU Lang, F
AF Lang, Florian
TI On the Pleotropic Actions of Mineralocorticoids
SO NEPHRON PHYSIOLOGY
LA English
DT Review
ID GLUCOCORTICOID-INDUCIBLE KINASE; ALDOSTERONE-REGULATED GENES; RECEPTOR
   ANTAGONISTS; HEART-FAILURE; DIABETIC-NEPHROPATHY; RENAL INFLAMMATION;
   METABOLIC SYNDROME; NONGENOMIC ACTIONS; EJECTION FRACTION; KLOTHO
   EXPRESSION
AB Classical effects of mineralocorticoids include stimulation of Na+ reabsorption and K+ secretion in the kidney and other epithelia including colon and several glands. Moreover, mineralocorticoids enhance the excretion of Mg2+ and renal tubular H+ secretion. The renal salt retention following mineralocorticoid excess leads to extracellular volume expansion and hypertension. The increase of blood pressure following mineralocorticoid excess is, however, not only the result of volume expansion but may result from stiff endothelial cell syndrome impairing the release of vasodilating nitric oxide. Beyond that, mineralocorticoids are involved in the regulation of a wide variety of further functions, including cardiac fibrosis, platelet activation, neuronal function and survival, inflammation as well as vascular and tissue fibrosis and calcification. Those functions are briefly discussed in this short introduction to the special issue. Beyond that, further contributions of this special issue amplify on mineralocorticoid-induced sodium appetite and renal salt retention, the role of mineralocorticoids in the regulation of acid-base balance, the involvement of aldosterone and its receptors in major depression, the mineralocorticoid stimulation of inflammation and tissue fibrosis and the effect of aldosterone on osteoinductive signaling and vascular calcification. Clearly, still much is to be learned about the various ramifications of mineralocorticoid-sensitive physiology and pathophysiology. (C) 2014 S. Karger AG, Basel
C1 Univ Tubingen, Dept Physiol, DE-72076 Tubingen, Germany.
C3 Eberhard Karls University of Tubingen
RP Lang, F (corresponding author), Univ Tubingen, Dept Physiol, Gmelinstr 5, DE-72076 Tubingen, Germany.
EM florian.lang@uni-tuebingen.de
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NR 138
TC 7
Z9 7
U1 1
U2 6
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1660-2137
J9 NEPHRON PHYSIOL
JI Nephron Physiol.
PY 2014
VL 128
IS 1-2
BP 1
EP 7
DI 10.1159/000368263
PG 7
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA AZ3TJ
UT WOS:000348149200001
PM 25376771
OA Bronze
DA 2025-06-11
ER

PT J
AU Kanika, ND
   Chang, JS
   Tong, YH
   Tiplitsky, S
   Lin, J
   Yohannes, E
   Tar, M
   Chance, M
   Christ, GJ
   Melman, A
   Davies, KD
AF Kanika, Nirmala D.
   Chang, Jinsook
   Tong, Yuehong
   Tiplitsky, Scott
   Lin, Juan
   Yohannes, Elizabeth
   Tar, Moses
   Chance, Mark
   Christ, George J.
   Melman, Arnold
   Davies, Kelvin D.
TI Oxidative stress status accompanying diabetic bladder cystopathy results
   in the activation of protein degradation pathways
SO BJU INTERNATIONAL
LA English
DT Article
DE diabetic cystopathy; oxidative stress; protein degradation
ID GLUTATHIONE S-TRANSFERASES; METABOLIC SYNDROME; RATS; DYSFUNCTION;
   EXPRESSION; BAX; STREPTOZOTOCIN; MICROARRAYS; APOPTOSIS; AUTOPHAGY
AB Diabetes is a common precursor for ladder pathology, including detrusor overactivity and cystopathy. There is preliminary, but increasing evidence, suggesting that oxidative stress plays a significant role in the development of diabetic complications including its affect on the bladder.
   In the present study we investigated the effect of streptozotocin induced-diabetes in rats on the global expression of genes in the rat bladder using microarray analysis, and combined this data with our previously reported study looking at changes in protein levels using proteomics. This analysis demonstrated that markers of oxidative stress were significantly increased in the diabetic bladder. Overall, our work adds to the growing body of evidence that diabetic cystopathy is associated with oxidative damage of smooth muscle cells, and results in protein damage and activation of apoptotic pathways which may contribute to a deterioration in bladder function.
   OBJECTIVE
   To investigate the role that oxidative stress plays in the development of diabetic cystopathy.
   MATERIALS AND METHODS
   Comparative gene expression in the bladder of non-diabetic and streptozotocin (STZ)-induced 2-month- old diabetic rats was carried out using microarray analysis.
   Evidence of oxidative stress was investigated in the bladder by analyzing glutathione S-transferase activity, lipid peroxidation, and carbonylation and nitrosylation of proteins.
   The activity of protein degradation pathways was assessed using Western blot analysis.
   RESULTS
   Analysis of global gene expression showed that detrusor smooth muscle tissue of STZ-induced diabetes undergoes significant enrichment in targets involved in the production or regulation of reactive oxygen species (P = 1.27 x 10-10). The microarray analysis was confirmed by showing that markers of oxidative stress were all significantly increased in the diabetic bladder.
   It was hypothesized that the sequelae to oxidative stress would be increased protein damage and apoptosis.
   This was confirmed by showing that two key proteins involved in protein degradation (Nedd4 and LC3B) were greatly up-regulated in diabetic bladders compared to controls by 12.2 +/- 0.76 and 4.4 +/- 1.0-fold, respectively, and the apoptosis inducing protein, BAX, was up-regulated by 6.76 +/- 0.76-fold.
   CONCLUSION
   Overall, the findings obtained in the present study add to the growing body of evidence showing that diabetic cystopathy is associated with oxidative damage of smooth muscle cells, and results in protein damage and activation of apoptotic pathways that may contribute to a deterioration in bladder function.
C1 [Kanika, Nirmala D.; Chang, Jinsook; Tong, Yuehong; Tiplitsky, Scott; Tar, Moses; Melman, Arnold; Davies, Kelvin D.] Albert Einstein Coll Med, Dept Urol, Bronx, NY 10461 USA.
   [Kanika, Nirmala D.; Chang, Jinsook; Tong, Yuehong; Tiplitsky, Scott; Tar, Moses; Melman, Arnold; Davies, Kelvin D.] Albert Einstein Coll Med, Inst Smooth Muscle Biol, Bronx, NY 10461 USA.
   [Lin, Juan] Albert Einstein Coll Med, Div Biostat, Bronx, NY 10461 USA.
   [Chang, Jinsook; Yohannes, Elizabeth; Chance, Mark] Case Western Reserve Univ, Sch Med, Ctr Prote & Bioinformat, Cleveland, OH USA.
   [Christ, George J.] Wake Forest Univ, Inst Regenerat Med, Winston Salem, NC 27109 USA.
C3 Yeshiva University; Montefiore Medical Center; Albert Einstein College
   of Medicine; Montefiore Medical Center; Albert Einstein College of
   Medicine; Yeshiva University; Yeshiva University; Montefiore Medical
   Center; Albert Einstein College of Medicine; University System of Ohio;
   Case Western Reserve University; Wake Forest University
RP Davies, KD (corresponding author), Albert Einstein Coll Med, Dept Urol, 1300 Morris Pk Ave, Bronx, NY 10461 USA.
EM kdavies@aecom.yu.edu
RI Yohannes, Elizabeth/AAM-4457-2020; Davies, Katherine/L-1882-2019
OI Davies, Kelvin/0000-0002-0201-9210
FU NIH/NIDDK [R01DK077665]
FX This work was supported by a grant awarded by the NIH/NIDDK to Kelvin P.
   Davies (R01DK077665).
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NR 32
TC 30
Z9 34
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1464-4096
EI 1464-410X
J9 BJU INT
JI BJU Int.
PD MAY
PY 2011
VL 107
IS 10
BP 1676
EP 1684
DI 10.1111/j.1464-410X.2010.09655.x
PG 9
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 755AN
UT WOS:000289899100023
PM 21518418
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Khera, M
AF Khera, Mohit
TI Male hormones and men's quality of life
SO CURRENT OPINION IN UROLOGY
LA English
DT Review
DE hormone; quality of life; testosterone
ID PLACEBO-CONTROLLED TRIALS; LATE-ONSET HYPOGONADISM; LOW SERUM
   TESTOSTERONE; BONE-MINERAL DENSITY; LOWER URINARY-TRACT; MIDDLE-AGED
   MEN; OLDER MEN; METABOLIC SYNDROME; BODY-COMPOSITION; PROSTATE-CANCER
AB Purpose of reviewMale hormones can significantly impact a man's quality of life. Recently, there has been controversy with the use of testosterone and its impact on a man's quality of life. These controversies include testosterone's effect on cardiovascular disease, benign prostatic hyperplasia, prostate cancer, and fertility. The purpose of this manuscript is to further evaluate mainly testosterone's effect in these controversial areas as well as testosterone's overall effect on a man's quality of life.Recent findingsRecent findings suggest that testosterone does not increase a man's risk of developing benign prostatic hyperplasia or prostate cancer. Men with low testosterone levels are more likely to suffer a cardiovascular event and develop insulin resistance. Exogenous testosterone is a natural contraceptive and men desiring to preserve their fertility should use mechanisms to raise their own natural endogenous testosterone production.SummaryAlthough testosterone deficiency can significantly impair a man's quality of life, testosterone therapy has been shown to significantly improve many of these qualities, such as depression, bone mineral density, energy, libido, erectile function, muscle mass, insulin resistance, and lower urinary tract symptoms. Testosterone therapy can be administered safely to symptomatic hypogonadal men.
C1 [Khera, Mohit] Baylor Coll Med, Houston, TX 77030 USA.
C3 Baylor College of Medicine
RP Khera, M (corresponding author), Baylor Coll Med, Scott Dept Urol, Urol, 7200 Cambridge St,10th Floor, Houston, TX 77030 USA.
EM mkhera@bcm.edu
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NR 62
TC 28
Z9 30
U1 0
U2 11
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0963-0643
EI 1473-6586
J9 CURR OPIN UROL
JI Curr. Opin. Urol.
PD MAR
PY 2016
VL 26
IS 2
BP 152
EP 157
DI 10.1097/MOU.0000000000000256
PG 6
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA DC9NI
UT WOS:000369547900005
PM 26765046
DA 2025-06-11
ER

PT S
AU Aghazadeh, Y
   Zirkin, BR
   Papadopoulos, V
AF Aghazadeh, Yasaman
   Zirkin, Barry R.
   Papadopoulos, Vassilios
BE Litwack, G
TI Pharmacological Regulation of the Cholesterol Transport Machinery in
   Steroidogenic Cells of the Testis
SO HORMONES AND TRANSPORT SYSTEMS
SE Vitamins and Hormones
LA English
DT Review; Book Chapter
ID LEYDIG TUMOR-CELLS; MITOCHONDRIAL OUTER-MEMBRANE; DIAZEPAM-BINDING
   INHIBITOR; LATE-ONSET HYPOGONADISM; BOVINE ADRENAL-CORTEX;
   PROTEIN-PROTEIN INTERACTIONS; ALPHA-ASSOCIATED PROTEIN; DEPENDENT ANION
   CHANNEL; CHAIN CLEAVAGE ENZYME; IN-VITRO SYNTHESIS
AB Reduced serum testosterone (T), or hypogonadism, is estimated to affect about 5 million American men, including both aging and young men. Low serum T has been linked to mood changes, worsening cognition, fatigue, depression, decreased lean body mass and bone mineral density, increased visceral fat, metabolic syndrome, decreased libido, and sexual dysfunction. Administering exogenous T, known as T-replacement therapy (TRT), reverses many of the symptoms of low T levels. However, this treatment can result in luteinizing hormone suppression which, in turn, can lead to reduced sperm numbers and infertility, making TRT inappropriate for men who wish to father children. Additionally, TRT may result in supraphysiologic T levels, skin irritation, and T transfer to others upon contact; and there may be increased risk of prostate cancer and cardiovascular disease, particularly in aging men. Therefore, the development of alternate therapies for treating hypogonadism would be highly desirable. To do so requires greater understanding of the series of steps leading to T formation and how they are regulated, and the identification of key steps that are amenable to pharmacological modulation so as to induce T production. We review herein our current understanding of mechanisms underlying the pharmacological induction of T formation in hypogonadal testis.
C1 [Aghazadeh, Yasaman; Papadopoulos, Vassilios] McGill Univ, Ctr Hlth, Res Inst, Montreal, PQ, Canada.
   [Aghazadeh, Yasaman; Papadopoulos, Vassilios] McGill Univ, Dept Med, Montreal, PQ, Canada.
   [Zirkin, Barry R.] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Biochem & Mol Biol, Baltimore, MD USA.
   [Papadopoulos, Vassilios] McGill Univ, Dept Biochem, Montreal, PQ, Canada.
   [Papadopoulos, Vassilios] McGill Univ, Dept Pharmacol & Therapeut, Montreal, PQ, Canada.
C3 McGill University; McGill University; Johns Hopkins University; Johns
   Hopkins Bloomberg School of Public Health; McGill University; McGill
   University
RP Papadopoulos, V (corresponding author), McGill Univ, Ctr Hlth, Res Inst, Montreal, PQ, Canada.
EM vassilios.papadopoulos@mcgill.ca
RI Papadopoulos, Vassilios/AAI-2613-2019
OI Papadopoulos, Vassilios/0000-0002-1183-8568
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NR 194
TC 51
Z9 56
U1 0
U2 10
PU ELSEVIER ACADEMIC PRESS INC
PI SAN DIEGO
PA 525 B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0083-6729
BN 978-0-12-803028-8; 978-0-12-803008-0
J9 VITAM HORM
JI Vitam. Horm.
PY 2015
VL 98
BP 189
EP 227
DI 10.1016/bs.vh.2014.12.006
PG 39
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Book Citation Index – Science (BKCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA BF5OW
UT WOS:000382402800008
PM 25817870
DA 2025-06-11
ER

PT J
AU Maty, SC
   Lynch, JW
   Raghunathan, TE
   Kaplan, GA
AF Maty, Siobhan C.
   Lynch, John W.
   Raghunathan, Trivellore E.
   Kaplan, George A.
TI Childhood socioeconomic position, gender, adult body mass index, and
   incidence of type 2 diabetes mellitus over 34 years in the Alameda
   County Study
SO AMERICAN JOURNAL OF PUBLIC HEALTH
LA English
DT Article
ID BRITISH WOMENS HEART; CAUSE-SPECIFIC MORTALITY; NUTRITION EXAMINATION
   SURVEY; 3RD NATIONAL-HEALTH; INSULIN-RESISTANCE; CARDIOVASCULAR-DISEASE;
   METABOLIC SYNDROME; BIRTH-WEIGHT; SOCIAL-CLASS; ABERDEEN CHILDREN
AB Objectives. We examined the association between childhood socioeconomic position and incidence of type 2 diabetes and the effects of gender and adult body mass index (BMI).
   Methods. We studied 5913 participants in the Alameda County Study from 1965 to 1999 who were diabetes free at baseline (1965). Cox proportional hazards models estimated diabetes risk associated with childhood socioeconomic position and combined childhood socioeconomic position-adult BMI categories in pooled and gender-stratified samples. Demographic confounders and potential pathway components (physical inactivity, smoking, alcohol consumption, hypertension, depression, health care access) were included as covariates.
   Results. Low childhood socioeconomic position was associated with excess diabetes risk, especially among women. Race and body composition accounted for some of this excess risk. The association between childhood socioeconomic position and diabetes incidence differed by adult BMI category in the pooled and women-only groups. Adjustment for race and behaviors attenuated the risk attributable to low childhood socioeconomic position among the obese group only.
   Conclusions. Childhood socioeconomic position was a robust predictor of incident diabetes, especially among women. A cumulative risk effect was observed for both childhood socioeconomic position and adult BMI, especially among women.
C1 [Maty, Siobhan C.] Portland State Univ, Sch Community Hlth, Portland, OR 97207 USA.
   [Lynch, John W.] McGill Univ, Dept Epidemiol Biostat & Occupat Hlth, Montreal, PQ, Canada.
   [Raghunathan, Trivellore E.] Univ Michigan, Dept Biostat, Ann Arbor, MI 48109 USA.
   [Raghunathan, Trivellore E.; Kaplan, George A.] Univ Michigan, Sch Publ Hlth, Ctr Social Epidemiol & Populat Hlth, Ann Arbor, MI 48109 USA.
   [Kaplan, George A.] Univ Michigan, Dept Epidemiol, Ann Arbor, MI 48109 USA.
C3 Portland State University; McGill University; University of Michigan
   System; University of Michigan; University of Michigan System;
   University of Michigan; University of Michigan System; University of
   Michigan
RP Maty, SC (corresponding author), Portland State Univ, Sch Community Hlth, POB 751, Portland, OR 97207 USA.
EM maty@pdx.edu
RI Lynch, John/A-4797-2008; Kaplan, George/AAJ-2398-2020
FU NIA NIH HHS [R37 AG011375, AG-011375] Funding Source: Medline; NICHD NIH
   HHS [R24 HD047861] Funding Source: Medline
CR [Anonymous], 1967, Cancer Epidemiology: Methods of Study
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NR 100
TC 75
Z9 90
U1 0
U2 21
PU AMER PUBLIC HEALTH ASSOC INC
PI WASHINGTON
PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA
SN 0090-0036
EI 1541-0048
J9 AM J PUBLIC HEALTH
JI Am. J. Public Health
PD AUG
PY 2008
VL 98
IS 8
BP 1486
EP 1494
DI 10.2105/AJPH.2007.123653
PG 9
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA 330KU
UT WOS:000257940800029
PM 18556612
OA Green Accepted, Green Submitted
DA 2025-06-11
ER

PT J
AU Novelli, L
   Lubrano, E
   Venerito, V
   Perrotta, FM
   Marando, F
   Curradi, G
   Iannone, F
AF Novelli, Lucia
   Lubrano, Ennio
   Venerito, Vincenzo
   Perrotta, Fabio Massimo
   Marando, Francesca
   Curradi, Giacomo
   Iannone, Florenzo
TI Extra-Articular Manifestations and Comorbidities in Psoriatic Disease: A
   Journey Into the Immunologic Crosstalk
SO FRONTIERS IN MEDICINE
LA English
DT Review
DE psoriatic arthritis; psoriatic disease; comorbidities; extra-articular
   manifestations; systemic inflammation; immunomodulation
ID ANTI-TNF-ALPHA; BONE-MINERAL DENSITY; RHEUMATOID-ARTHRITIS;
   NECROSIS-FACTOR; MAINTENANCE THERAPY; CROHNS-DISEASE; UVEITIS;
   INFLAMMATION; DEPRESSION; RISK
AB Psoriatic arthritis (PsA) is a chronic inflammatory disease primarily affecting peripheral and axial joints, with the possible presence of extra-articular manifestations (EAMs), such as psoriasis, uveitis, and inflammatory bowel disease. Recently, the concept of psoriatic disease (PsD) has been proposed to define a systemic condition encompassing, in addition to joints and EAMs, some comorbidities (e.g., metabolic syndrome, type II diabetes, hypertension) that can affect the disease outcome and the achievement of remission. EAMs and comorbidities in PsA share common immunopathogenic pathways linked to the systemic inflammation of this disease; these involve a broad variety of immune cells and cytokines. Currently, various therapeutics are available targeting different cytokines and molecules implicated in the inflammatory response of this condition; however, despite an improvement in the management of PsA, comprehensive disease control is often not achievable. There is, therefore, a big gap to fill especially in terms of comorbidities and EAMs management. In this review, we summarize the clinical aspects of the main comorbidities and EAMs in PsA, and we focus on the immunopathologic features they share with the articular manifestations. Moreover, we discuss the effect of a diverse immunomodulation and the current unmet needs in PsD.</p>
C1 [Novelli, Lucia; Marando, Francesca; Curradi, Giacomo] AbbVie Srl, Dept Med, Rome, Italy.
   [Lubrano, Ennio; Perrotta, Fabio Massimo] Univ Molise, Dept Med & Hlth Sci Vincenzo Tiberio, Campobasso, Italy.
   [Venerito, Vincenzo; Iannone, Florenzo] Univ Bari Aldo Moro, Dept Emergency & Organ Transplantat, Rheumatol Unit, Bari, Italy.
C3 AbbVie; University of Molise; Universita degli Studi di Bari Aldo Moro
RP Iannone, F (corresponding author), Univ Bari Aldo Moro, Dept Emergency & Organ Transplantat, Rheumatol Unit, Bari, Italy.
EM florenzo.iannone@uniba.it
RI Novelli, Lucia/GOE-5955-2022; Venerito, Vincenzo/HKV-1293-2023; Iannone,
   Florenzo/AIC-3027-2022
OI Venerito, Vincenzo/0000-0002-2573-5930; Novelli,
   Lucia/0000-0002-9639-0909; Curradi, Giacomo/0000-0002-3310-5541
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NR 159
TC 20
Z9 21
U1 1
U2 3
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 2296-858X
J9 FRONT MED-LAUSANNE
JI Front. Med.
PD SEP 23
PY 2021
VL 8
AR 737079
DI 10.3389/fmed.2021.737079
PG 14
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA WD6MW
UT WOS:000705054400001
PM 34631754
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Nussbaumer-Ochsner, Y
   Rabe, KF
AF Nussbaumer-Ochsner, Yvonne
   Rabe, Klaus F.
TI Systemic Manifestations of COPD
SO CHEST
LA English
DT Article
ID OBSTRUCTIVE PULMONARY-DISEASE; AIR-FLOW OBSTRUCTION; C-REACTIVE PROTEIN;
   SMOKING-CESSATION; GLOBAL BURDEN; FLUTICASONE PROPIONATE;
   ATHEROSCLEROSIS RISK; OLDER PATIENTS; LUNG-FUNCTION; MORTALITY
AB COPD is characterized by a poorly reversible airflow limitation resulting from chronic inflammation, mainly due to tobacco exposure. Over the past few years, the understanding of COPD has evolved from it being a disease affecting the lungs to it being a complex, heterogeneous, and generalized disorder in an aging population. Extrapulmonary comorbidities significantly complicate the management and influence the prognosis of patients with COPD. Although certain comorbidities like cardiovascular diseases share some risk factors with COPD, such as cigarette smoking, other frequently observed comorbidities, including musculoskeletal wasting, metabolic syndrome, and depression, cannot be easily attributed to smoking. There is increasing evidence that chronic inflammation is a key factor in COPD and that inflammation might be the common pathway linking these comorbidities and explaining why they typically develop together. Physicians treating patients with COPD need to become aware of these extrapulmonary aspects. Any patient with COPD should be carefully evaluated for comorbidities and the systemic consequences of COPD since they not only influence the prognosis but also have an impact on disease management. The treatment of COPD is no longer focused exclusively on inhaled therapy but is taking on a multidimensional approach, especially because the treatment of the comorbidities might positively affect the course of COPD itself. CHEST 2011; 139(1):165-173
C1 [Nussbaumer-Ochsner, Yvonne; Rabe, Klaus F.] Leiden Univ, Med Ctr, Dept Pulmonol, NL-2333 ZA Leiden, Netherlands.
C3 Leiden University; Leiden University Medical Center (LUMC); Leiden
   University - Excl LUMC
RP Nussbaumer-Ochsner, Y (corresponding author), Leiden Univ, Med Ctr, Dept Pulmonol, C3-P,Albinusdreef 2, NL-2333 ZA Leiden, Netherlands.
EM k.f.rabe@lumc.nl
RI Rabe, Klaus/AAW-6296-2021
OI Rabe, Klaus F./0000-0002-7020-1401
FU AstraZeneca; Boehringer; Chiesi Pharmaceuticals; Pfizer; Novartis;
   Nycomed; MSD; GaxoSmithKline (GSK); Boehringer Ingelheim; Roche
FX The authors have reported to CHEST the following conflicts of interest:
   Dr Rabe has consulted for, participated in advisory board meetings with,
   and received lecture fees from AstraZeneca, Boehringer, Chiesi
   Pharmaceuticals, Pfizer, Novartis, Nycomed, MSD, and GaxoSmithKline
   (GSK). The Department of Pulmonology, and, therefore, Dr Rabe, as head
   of the department, received grants from Novartis, AstraZeneca,
   Boehringer Ingelheim, Nycomed, Roche, and GSK from 2005 to 2009. Dr
   Nussbaumer-Ochsner has reported that no potential conflicts of interest
   exist with any companies/organizations whose products or services may be
   discussed in this article.
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NR 72
TC 166
Z9 190
U1 0
U2 26
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0012-3692
J9 CHEST
JI Chest
PD JAN
PY 2011
VL 139
IS 1
BP 165
EP 173
DI 10.1378/chest.10-1252
PG 9
WC Critical Care Medicine; Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Respiratory System
GA 710EJ
UT WOS:000286493400027
PM 21208876
DA 2025-06-11
ER

PT J
AU Patel, VV
   Rajpathak, S
   Karasz, A
AF Patel, Viraj V.
   Rajpathak, Swapnil
   Karasz, Alison
TI Bangladeshi Immigrants in New York City: A Community Based Health Needs
   Assessment of a Hard to Reach Population
SO JOURNAL OF IMMIGRANT AND MINORITY HEALTH
LA English
DT Article
DE Bangladeshi; South Asian immigrants; Community based participatory
   research; Needs assessment
ID SOUTH ASIAN WOMEN; CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME;
   PHYSICAL-ACTIVITY; AMERICANS; RISK; MINORITIES; INDIANS
AB South Asians, particularly Bangladeshis, are one of the fastest growing immigrant groups in the U.S. Limited data exist regarding the health needs of Bangladeshis in the U.S. More data are needed to guide health intervention efforts for this community. To help address this gap, we conducted a community-based health needs assessment survey among women in a Bangladeshi population living in Bronx, NY. Community health promoters conducted a door-to-door household survey and collected data from 167 women, an approach that yielded a participation rate over 90%. Over half reported fair or poor health and 36.5% screened positive for risk of depression. Only 35% had engaged in physical activity over the past month. 60% reported never having received a pap smear. Using WHO guidelines for BMI, 74% were either overweight or obese. Age-standardized prevalence of type 2 diabetes and hypertension were 15.4 and 36.5% respectively. In a multivariable logistic regression model, age and percent lifetime in the U.S. were independently associated with having diabetes. Poor health behaviors and high prevalence of cardiovascular risk factors observed in this group suggest the need for early health promotion and prevention interventions.
C1 [Patel, Viraj V.; Karasz, Alison] Albert Einstein Coll Med, Dept Family & Social Med, Bronx, NY 10461 USA.
   [Patel, Viraj V.] N Bronx Hlth Network, Dept Family Med, Bronx, NY USA.
   [Patel, Viraj V.] Montefiore Med Ctr, Dept Med, Bronx, NY 10467 USA.
   [Rajpathak, Swapnil] Albert Einstein Coll Med, Dept Epidemiol & Populat Hlth, Bronx, NY 10467 USA.
C3 Yeshiva University; Montefiore Medical Center; Albert Einstein College
   of Medicine; Montefiore Medical Center; Albert Einstein College of
   Medicine; Yeshiva University; Montefiore Medical Center; Albert Einstein
   College of Medicine
RP Patel, VV (corresponding author), Albert Einstein Coll Med, Dept Family & Social Med, 1300 Morris Pk Ave,Mazer Suite 414, Bronx, NY 10461 USA.
EM vpatel@montefiore.org
OI Patel, Viraj V/0000-0002-5603-9823
FU NIMH NIH HHS [R21 MH083892, 5R21MH083892-02] Funding Source: Medline
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NR 33
TC 30
Z9 41
U1 0
U2 28
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1557-1912
EI 1557-1920
J9 J IMMIGR MINOR HEALT
JI J. Immigr. Minor. Health
PD OCT
PY 2012
VL 14
IS 5
BP 767
EP 773
DI 10.1007/s10903-011-9555-5
PG 7
WC Public, Environmental & Occupational Health
WE Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA 004BX
UT WOS:000308656200006
PM 22116745
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Chen, PH
   Chang, CK
   Chiang, SJ
   Lin, YK
   Tsai, SY
   Huane, SH
AF Chen, Pao-Huan
   Chang, Chi-Kang
   Chiang, Shuo-Ju
   Lin, Yen-Kuang
   Tsai, Shang-Ying
   Huane, Shou-Hung
TI Diabetes mellitus and first episode mania associated with cardiovascular
   diseases in patients with older-age bipolar disorder
SO PSYCHIATRY RESEARCH
LA English
DT Article
DE Bipolar disorder; Ischemic heart disease; Hypertension; Diabetes
   mellitus; Obesity; Mania
ID MANIC/HYPOMANIC SYMPTOM BURDEN; ALCOHOL-USE DISORDER; METABOLIC
   SYNDROME; MEDICAL MORBIDITY; RISK; DEPRESSION; MORTALITY; OBESITY;
   SCHIZOPHRENIA; PEOPLE
AB Patients with bipolar disorder (BD) are at high risk for developing cardiovascular diseases (CVDs) during aging process. However, investigations are lacking regarding the risk factors for CVDs specific to BD patients. The aim of this study was to examine the relationship between CVDs and traditional risk factors in association with the characteristics of BD in older age. Totally, we recruited 124 patients with BD-I (DSM-IV) who had at least one psychiatric admission and cardiologist-confirmed CVD diagnosis (ICD-9 code 401-414) at mean age of 61.7 +/- 4.9 years. Each case subject was matched with one BD-I patient without CVDs based on age, sex, and date of the most recent psychiatric admission (2 years). Clinical data were obtained by retrospectively reviewing the medical record. A multiple logistic regression model showed that not only traditional risk factor (e.g., diabetes mellitus) but also non-traditional one associated with BD (e.g., first episode mania) significantly increased the risk of CVDs. Given the limitation of this cross-sectional study, longitudinal investigations are needed to elucidate the contributions of both traditional risk factors and the BD characteristics for CVD risk in patients with BD.
C1 [Chen, Pao-Huan; Tsai, Shang-Ying; Huane, Shou-Hung] Taipei Med Univ Hosp, Dept Psychiat, 252 Wu Hsing St, Taipei 110, Taiwan.
   [Chen, Pao-Huan; Tsai, Shang-Ying; Huane, Shou-Hung] Taipei Med Univ, Coll Med, Sch Med, Dept Psychiat, Taipei, Taiwan.
   [Chang, Chi-Kang] Taipei City Hosp, Taipei City Psychiat Ctr, Dept Psychiat, Taipei, Taiwan.
   [Chiang, Shuo-Ju] Taipei Med Univ Hosp, Dept Internal Med, Div Cardiol, Taipei, Taiwan.
   [Chiang, Shuo-Ju] Taipei Med Univ, Coll Med, Sch Med, Dept Internal Med, Taipei, Taiwan.
   [Lin, Yen-Kuang] Taipei Med Univ, Ctr Biostat, Taipei, Taiwan.
C3 Taipei Medical University; Taipei Medical University Hospital; Taipei
   Medical University; Taipei City Hospital; Taipei Medical University;
   Taipei Medical University Hospital; Taipei Medical University; Taipei
   Medical University
RP Chen, PH (corresponding author), Taipei Med Univ Hosp, Dept Psychiat, 252 Wu Hsing St, Taipei 110, Taiwan.
EM b8601115@tmu.edu.tw
RI Chen, Pao-Huan/ABG-5963-2020
OI TSAI, SHANGYING/0000-0001-5662-0055
FU Ministry of Science and Technology, Taiwan [MOST 104-2314-B-038-022]
FX This study was supported by a research grant from the Ministry of
   Science and Technology, Taiwan (MOST 104-2314-B-038-022). The authors
   thank Miss Tse-Yi Chen for her administrative support.
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NR 40
TC 12
Z9 12
U1 2
U2 4
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0165-1781
J9 PSYCHIAT RES
JI Psychiatry Res.
PD MAR
PY 2017
VL 249
BP 65
EP 69
DI 10.1016/j.psychres.2017.01.004
PG 5
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA EP4VI
UT WOS:000397377600011
PM 28073032
DA 2025-06-11
ER

PT J
AU Gooren, LJ
   Behre, HM
AF Gooren, Louis J.
   Behre, Hermann M.
TI Diagnosing and treating testosterone deficiency in different parts of
   the world: changes between 2006 and 2010
SO AGING MALE
LA English
DT Article
DE Attitudes; diagnosis; regional difference; side effects; testosterone;
   treatment
ID METABOLIC SYNDROME; ERECTILE DYSFUNCTION; CLINICAL-PRACTICE; OBESE MEN;
   OLDER MEN; SYMPTOMS; THERAPY; METAANALYSIS; TADALAFIL; ONSET
AB Aim: An analysis of variations in diagnosing and treating testosterone (T) deficiency between different regions of the world in 2006 was repeated in 2010. Methods: Physicians were interviewed in Germany, Spain, the United Kingdom, Brazil and Saudi Arabia about (1) reasons to use/not to use T. (2) safety (prostate pathology) and other concerns in the decision not to provide T treatment. (3) the actual usage of T preparations for treatment of erectile dysfunction (ED). Results: More men were treated with T in 2010. ED and lack of libido (2006) but also depression and obesity (2010) were regarded as symptoms of T deficiency. For 70% of physicians, severity of complaints was more significant than the laboratory value of T to prescribe T, more so in Germany (96%) than in Spain and Saudi Arabia. Concerns about prostate disease remained strong and, therefore, 11% of eligible patients did not receive T. PDE-5 inhibitors are more often combined with T in 2010 for ED. Conclusion: More appropriate studies and more education of physicians are needed on diagnosing T deficiency, on the role of T in ED and on the evidence-based relative safety of T treatment.
C1 [Gooren, Louis J.] Vrije Univ, Dept Endocrinol, Med Ctr, Amsterdam, Netherlands.
   [Behre, Hermann M.] Univ Halle Wittenberg, Ctr Reprod Med & Androl, Halle, Germany.
C3 Vrije Universiteit Amsterdam; Martin Luther University Halle Wittenberg
RP Gooren, LJ (corresponding author), 72-1 Moo1, Chiang Mai 50220, Thailand.
EM louisjgooren@gmail.com
FU Bayer Pharma AG, Berlin, Germany
FX The survey was performed by Genactis GmbH, Cologne, Germany, and funded
   by Bayer Pharma AG, Berlin, Germany. LG has received compensation for
   lectures by Bayer Pharma AG Berlin, Germany. HB has received
   compensation for lectures by Bayer Pharma AG Berlin, Germany and Ferring
   Pharmaceuticals.
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NR 20
TC 27
Z9 29
U1 0
U2 3
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 1368-5538
J9 AGING MALE
JI Aging Male
PD MAR
PY 2012
VL 15
IS 1
BP 22
EP 27
DI 10.3109/13685538.2011.650246
PG 6
WC Endocrinology & Metabolism; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Urology & Nephrology
GA 886GB
UT WOS:000299840800004
PM 22284307
OA Bronze
DA 2025-06-11
ER

PT J
AU Akter, R
   Afrose, A
   Sharmin, S
   Rezwan, R
   Rahman, R
   Neeletol, S
AF Akter, Raushanara
   Afrose, Afrina
   Sharmin, Shahana
   Rezwan, Rifat
   Rahman, Rashidur
   Neeletol, Sharmind
TI A comprehensive look into the association of vitamin D levels and
   vitamin D receptor gene polymorphism with obesity in children
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Review
DE Vit-D; Obesity; Children; VDR gene polymorphisms; Single nuclear
   polymorphisms (SNPs)
ID SERUM 25-HYDROXYVITAMIN D; CARDIOVASCULAR RISK-FACTORS; D DEFICIENCY;
   PARATHYROID-HORMONE; METABOLIC SYNDROME; HYPOVITAMINOSIS-D; D-BINDING;
   1,25-DIHYDROXYVITAMIN-D PRODUCTION; NUTRITIONAL RICKETS; INSULIN
   SENSITIVITY
AB Childhood obesity accounts for several psychosocial and clinical consequences. Psychosocial consequences include lower self-esteem, social isolation, poor academic achievement, peer problems, and depression, whereas clinical consequences are cardiovascular diseases, type 2 diabetes, dyslipidemia, cancer, autoimmune diseases, girls early polycystic ovarian syndrome (PCOS), asthma, bone deformities, etc. A growing number of studies have uncovered the association of childhood obesity and its consequences with vitamin-D (vit-D) deficiency and vitamin-D receptor (VDR) gene polymorphisms such as single nucleotide polymorphisms (SNPs), e.g., TaqI, BsmI, ApaI, FokI, and Cdx2. Considering the impact of vit-D deficiency and VDR gene polymorphisms, identifying associated factors and risk groups linked to lower serum vit-D levels and prevention of obesity-related syndromes in children is of utmost importance. Previously published review articles mainly focused on the association of vitD deficiency with obesity or other non-communicable diseases in children. The nature of the correlation between vit-D deficiency and VDR gene polymorphisms with obesity in children is yet to be clarified. Therefore, this review attempts to delineate the association of obesity with these two factors by identifying the molecular mechanism of the relationship.
C1 [Akter, Raushanara; Afrose, Afrina; Sharmin, Shahana; Rezwan, Rifat; Neeletol, Sharmind] Brac Univ, Sch Pharm, 66 Mohakhali, Dhaka, Bangladesh.
   [Rahman, Rashidur] Jashore Univ Sci & Technol, Dept Pharm, Jashore 7408, Bangladesh.
C3 Bangladesh Rural Advancement Committee BRAC; BRAC University
RP Neeletol, S (corresponding author), Brac Univ, Sch Pharm, 66 Mohakhali, Dhaka, Bangladesh.
EM sharmind@bracu.ac.bd
RI Neelotpol, Sharmind/V-7191-2019; Akter, Raushanara/AGO-7118-2022;
   Afrose, Afrina/IGY-3708-2023
OI Rezwan, Rifat/0000-0003-0578-8848; Rahman, Md
   Rashidur/0000-0002-0816-6430; Neelotpol, Sharmind/0000-0001-6770-4457
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PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD SEP
PY 2022
VL 153
AR 113285
DI 10.1016/j.biopha.2022.113285
PG 16
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA 2J6UL
UT WOS:000815789100013
PM 35728355
OA gold
DA 2025-06-11
ER

PT J
AU Chen, DH
   Liu, XL
   Zhang, WP
   Shi, YG
AF Chen, Daohong
   Liu, Xiaolei
   Zhang, Weiping
   Shi, Yuguang
TI Targeted Inactivation of GPR26 Leads to Hyperphagia and Adiposity by
   Activating AMPK in the Hypothalamus
SO PLOS ONE
LA English
DT Article
ID PROTEIN-COUPLED RECEPTOR; DIET-INDUCED OBESITY; FOOD-INTAKE;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; KINASE; MICE; DISRUPTION;
   RIMONABANT; DEPRESSION
AB G-protein coupled receptor 26 (GPR26) is a brain-specific orphan GPCR with high expression in the brain region that controls satiety. Depletion of GPR26 has been shown to increase fat storage in C. elegans, whereas GPR26 deficiency in the hypothalamus is associated with high genetic susceptibility to the onset of obesity in mice. However, the metabolic function of GPR26 in mammals remains elusive. Herein, we investigated a role of GPR26 in regulating energy homeostasis by generating mice with targeted deletion of the GPR26 gene. We show that GPR26 deficiency causes hyperphagia and hypometabolism, leading to early onset of diet-induced obesity. Accordingly, GPR26 deficiency also caused metabolic complications commonly associated with obesity, including glucose intolerance, hyperinsulinemia, and dyslipidemia. Moreover, consistent with hyperphagia in GPR26 null mice, GPR26 deficiency significantly increased hypothalamic activity of AMPK, a key signaling event that stimulates appetite. In further support of a regulatory role of GPR26 in satiety, GPR26 knockout mice also demonstrate hypersensitivity to treatment of rimonabant, an endocannabinoid receptor-1 antagonist commonly used to treat obesity by suppressing appetite in humans. Together, these findings identified a key role of GPR26 as a central regulator of energy homeostasis though modulation of hypothalamic AMPK activation.
C1 [Chen, Daohong; Liu, Xiaolei; Shi, Yuguang] Penn State Univ, Coll Med, Dept Cellular & Mol Physiol, Hershey, PA USA.
   [Liu, Xiaolei] Cent S Univ, Sch Pharmaceut Sci, Dept Pharmacol, Changsha, Hunan, Peoples R China.
   [Zhang, Weiping] Second Mil Med Univ Shanghai, Dept Pathophysiol, Shanghai, Peoples R China.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE);
   Pennsylvania State University; Penn State Health; Central South
   University; Naval Medical University
RP Chen, DH (corresponding author), Penn State Univ, Coll Med, Dept Cellular & Mol Physiol, Hershey, PA USA.
EM yus11@psu.edu
FU National Institutes of Health [DK076685]; National Natural Science
   Foundation of China [31025013, 81130084]; National Key Basic Research
   Program of China [2012CB524900]; National "863" Program of China
   [2007AA02Z173]
FX This study was supported in part by grants from the National Institutes
   of Health (DK076685 to YS), National Natural Science Foundation of China
   (31025013 and 81130084 to WZ), National Key Basic Research Program of
   China (2012CB524900 to WZ), and National "863" Program of China
   (2007AA02Z173 to WZ). The funders had no role in study design, data
   collection and analysis, decision to publish, or preparation of the
   manuscript.
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TC 13
Z9 13
U1 1
U2 9
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JUL 16
PY 2012
VL 7
IS 7
AR e40764
DI 10.1371/journal.pone.0040764
PG 10
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 974VS
UT WOS:000306466100063
PM 22815809
OA Green Submitted, gold, Green Published
DA 2025-06-11
ER

PT J
AU Giltay, EJ
   Gooren, LJG
AF Giltay, Erik J.
   Gooren, Louis J. G.
TI Potential Side Effects of Androgen Deprivation Treatment in Sex
   Offenders
SO JOURNAL OF THE AMERICAN ACADEMY OF PSYCHIATRY AND THE LAW
LA English
DT Article
ID HORMONE-BINDING GLOBULIN; BONE LOSS; PROSTATE-CANCER;
   CARDIOVASCULAR-DISEASE; INDUCED HYPOGONADISM; INSULIN SENSITIVITY; MEN;
   THERAPY; TESTOSTERONE; OSTEOPOROSIS
AB Testosterone is an important hormone involved in sexual arousal, and, indeed, a profound reduction of testosterone levels may be helpful in controlling sexual impulses in sex offenders. Earlier thought of as a sex hormone only, testosterone has been increasingly shown to have manifold actions in the adult male. Normal adult levels of androgens are required for the health of bones, a large number of metabolic functions, mood, erythropoiesis, sebaceous gland activity of the skin, and several other functions. Severe androgen deficiency is associated with pathologies of these biological systems. Androgen deprivation therapy may result in osteoporosis, weight gain with an increased visceral adiposity, impaired glucose tolerance, dyslipidemia, and emotional disturbances. Some of these features combine in the metabolic syndrome that is also frequently associated with the use of psychotropic medication in general. It leads to a moderately increased risk of fractures and diabetes mellitus (by 40%-50%), and a small increased risk of cardiovascular morbidity and depression (by 10%-20%). It should be noted that small proportionate increases in risk may be of modest clinical significance when background risks are very low. Effective and safe management of sex offenders treated with testosterone-deprivation therapy should include careful monitoring of side effects and their prevention and treatment.
C1 [Giltay, Erik J.] Leiden Univ, Med Ctr, Dept Psychiat, NL-2300 RC Leiden, Netherlands.
   [Gooren, Louis J. G.] Vrije Univ Amsterdam Med Ctr, Androl Unit, Dept Endocrinol, Amsterdam, Netherlands.
C3 Leiden University - Excl LUMC; Leiden University; Leiden University
   Medical Center (LUMC); Vrije Universiteit Amsterdam; VU UNIVERSITY
   MEDICAL CENTER
RP Giltay, EJ (corresponding author), Leiden Univ, Med Ctr, Dept Psychiat, Postbus 9600, NL-2300 RC Leiden, Netherlands.
EM giltay@dds.nl
RI Giltay, Erik/AAL-9948-2021
OI Giltay, Erik J./0000-0001-8874-2292
CR [Anonymous], TECHN REP SER WHO
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NR 57
TC 31
Z9 32
U1 0
U2 7
PU AMER ACAD PSYCHIATRY & LAW
PI BLOOMFIELD
PA ONE REGENCY DR, PO BOX 30, BLOOMFIELD, CT 06002 USA
SN 1093-6793
EI 1943-3662
J9 J AM ACAD PSYCHIATRY
JI J. Am. Acad. Psychiatry Law
PY 2009
VL 37
IS 1
BP 53
EP 58
PG 6
WC Law; Psychiatry
WE Social Science Citation Index (SSCI)
SC Government & Law; Psychiatry
GA 441ZK
UT WOS:000265809000009
PM 19297634
DA 2025-06-11
ER

PT J
AU Kim, Y
   Jang, S
   Ullahansari, S
   Vo, J
   Hyun, K
   Fadel, PJ
AF Kim, Yeonwoo
   Jang, Soeun
   Ullahansari, Shaikh
   Vo, Jimmy
   Hyun, Kate
   Fadel, Paul J.
TI Neighborhood Safety and Hypertension Risk: A Systematic Review
SO JOURNAL OF THE AMERICAN HEART ASSOCIATION
LA English
DT Article
DE blood pressure; hypertension risk; neighborhood effects on health;
   neighborhood safety
ID PHYSICAL-ACTIVITY; CARDIOMETABOLIC RISK; MATERNAL STRESS; ASSOCIATIONS;
   HEALTH; CRIME; ENVIRONMENTS; COHESION; OUTCOMES; DISEASE
AB Background Responding to the increasing focus on residential environments, our systematic review aimed to consolidate existing empirical evidence regarding the impact of neighborhood safety on blood pressure. We also summarized the mediating and moderating mechanisms through which neighborhood safety influences blood pressure, alongside their direct effects, to offer insights for future research.Methods We searched 5 electronic databases (PubMed, Ovid MEDLINE, CINAHL Complete, ProQuest Dissertations and Theses Global, and Web of Science) for the period up to and including December 27, 2022. The initial search yielded 4944 studies reviewed, of which 19 met our criteria and were reviewed.Results Our findings consistently show that living in a safe neighborhood is associated with lower blood pressure outcomes. While most cross-sectional studies found that the association was not statistically significant (7/10 studies showed insignificant results), longitudinal studies that tracked changes in neighborhood safety over time (4/5 studies) showed significant negative associations between neighborhood safety and blood pressure. Additionally, some studies identified sex (n=3), age (n=2), and neighborhood characteristics (n=4) as significant moderators, with the strength of the association between neighborhood safety and blood pressure varying across different demographic groups and neighborhood contexts.Conclusions Our findings suggest that unsafe neighborhoods may increase blood pressure and hypertension risk, warranting further research and interventions. This review also highlights the importance of adopting longitudinal designs, especially those using time-varying measures of neighborhood environments.
C1 [Kim, Yeonwoo; Ullahansari, Shaikh; Vo, Jimmy; Fadel, Paul J.] Univ Texas Arlington, Sch Social Work, Dept Kinesiol, Arlington, TX 76019 USA.
   [Hyun, Kate] Univ Texas Arlington, Dept Civil Engn, Arlington, TX 76019 USA.
C3 University of Texas System; University of Texas Arlington; University of
   Texas System; University of Texas Arlington
RP Kim, Y (corresponding author), Univ Texas Arlington, Dept Kinesiol, Publ Hlth Program, 411 S Nedderman Dr,Box 19407, Arlington, TX 76019 USA.
EM yeonwoo.kim@uta.edu
OI Jang, Soeun/0009-0007-2799-9327
FU National Institute on Aging (NIA) [R24AG045061]; Moritz Chair in
   Geriatrics, College of Nursing and Health Innovation, University of
   Texas at Arlington
FX This research was principally supported by the Network on Life Course
   Health Dynamics and Disparities in 21st Century America via grant number
   R24AG045061 from National Institute on Aging (NIA). Paul J. Fadel is
   supported by the Moritz Chair in Geriatrics, College of Nursing and
   Health Innovation, University of Texas at Arlington.
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NR 68
TC 0
Z9 0
U1 1
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
EI 2047-9980
J9 J AM HEART ASSOC
JI J. Am. Heart Assoc.
PD APR 15
PY 2025
VL 14
IS 8
AR e035381
DI 10.1161/JAHA.124.035381
PG 14
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 1KB8N
UT WOS:001466899100001
PM 40178095
OA gold
DA 2025-06-11
ER

PT J
AU Sollerhed, AC
   Lilja, E
   Holmgren, EH
   Garmy, P
AF Sollerhed, Ann-Christin
   Lilja, Emma
   Heldt Holmgren, Emily
   Garmy, Pernilla
TI Subjective Health, Physical Activity, Body Image and School Wellbeing
   among Adolescents in South of Sweden
SO NURSING REPORTS
LA English
DT Article
DE subjective health; physical activity; body image; body appearance; body
   functioning; wellbeing in school; body mass index; gender
ID ACADEMIC-ACHIEVEMENT; SEDENTARY BEHAVIOR; CARDIOMETABOLIC RISK;
   CHILDREN; ASSOCIATIONS; SELF; COMPETENCE; EXERCISE; FITNESS; STRESS
AB This study aimed to investigate subjective health and its associations with perceived body image (body appearance and body functioning), physical activity, perceived wellbeing in school, perceived family financial situation, and body mass index among 13- to 15-year-old boys and girls. The study was a cross-sectional study performed in four municipalities in Southern Sweden. Data were obtained from questionnaires completed by adolescents (median age 14; range: 13-15) in Sweden (n = 1518, 51% girls), with a participation rate of 73%. Body weight and body height were measured by school nurses and body mass index was calculated. Logistic regression analyses were carried out with subjective health as the dependent variable. Independent variables included in the model were perceived wellbeing in school, perceived family financial situation, perceived body image, physical activity, body mass index, sex, and residency. Variables significantly associated with good subjective health were good wellbeing in school, a perceived good family financial situation, perceived positive body appearance, perceived positive body functioning, being a boy, and high physical activity. Residency and body mass index were not associated with subjective health. Good subjective health is associated with good wellbeing in school, good family financial situation, positive body image, and high physical activity levels. The results highlight the importance of good school climates, the promotion of positive body image, and increased physical activity for adolescents.
C1 [Sollerhed, Ann-Christin] Kristianstad Univ, Fac Educ, Dept Nursing & Hlth Sci, SE-29188 Kristianstad, Sweden.
   [Lilja, Emma; Heldt Holmgren, Emily; Garmy, Pernilla] Kristianstad Univ, Fac Hlth Sci, Dept Humanities, SE-29188 Kristianstad, Sweden.
   [Garmy, Pernilla] Lund Univ, Dept Hlth Sci, Fac Med, SE-22100 Lund, Sweden.
C3 Kristianstad University; Kristianstad University; Lund University
RP Garmy, P (corresponding author), Kristianstad Univ, Fac Hlth Sci, Dept Humanities, SE-29188 Kristianstad, Sweden.; Garmy, P (corresponding author), Lund Univ, Dept Hlth Sci, Fac Med, SE-22100 Lund, Sweden.
EM ann-christin.sollerhed@hkr.se; emmalilja1985@gmail.com;
   kram_emily@hotmail.com; pernilla.garmy@med.lu.se
RI Garmy, Pernilla/J-2389-2019
OI Sollerhed, Ann-christin/0000-0003-2320-1326; Garmy,
   Pernilla/0000-0003-1643-0171
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NR 71
TC 7
Z9 7
U1 3
U2 21
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 2039-439X
EI 2039-4403
J9 NURS REP
JI Nurs. Rep.
PD DEC
PY 2021
VL 11
IS 4
BP 811
EP 822
DI 10.3390/nursrep11040076
PG 12
WC Nursing
WE Emerging Sources Citation Index (ESCI)
SC Nursing
GA XW4AN
UT WOS:000735564200001
PM 34968270
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Alenazi, AM
   Alhowimel, AS
   Alshehri, MM
   Alqahtani, BA
   Alhwoaimel, NA
   Segal, NA
   Kluding, PM
AF Alenazi, Aqeel M.
   Alhowimel, Ahmed S.
   Alshehri, Mohammed M.
   Alqahtani, Bader A.
   Alhwoaimel, Norah A.
   Segal, Neil A.
   Kluding, Patricia M.
TI Osteoarthritis and Diabetes: Where Are We and Where Should We Go?
SO DIAGNOSTICS
LA English
DT Review
DE osteoarthritis; diabetics; high blood glucose; pain intensity; symptoms;
   gait; pace
ID RADIOGRAPHIC KNEE OSTEOARTHRITIS; EARLY POSTOPERATIVE OUTCOMES;
   CLINICALLY DIAGNOSED KNEE; HAND OSTEOARTHRITIS; RISK-FACTORS; METABOLIC
   SYNDROME; GENERALIZED OSTEOARTHRITIS; UNITED-STATES; WALKING SPEED;
   ASSOCIATION
AB Diabetes mellitus (DM) and osteoarthritis (OA) are chronic noncommunicable diseases that affect millions of people worldwide. OA and DM are prevalent worldwide and associated with chronic pain and disability. Evidence suggests that DM and OA coexist within the same population. The coexistence of DM in patients with OA has been linked to the development and progression of the disease. Furthermore, DM is associated with a greater degree of osteoarthritic pain. Numerous risk factors are common to both DM and OA. Age, sex, race, and metabolic diseases (e.g., obesity, hypertension, and dyslipidemia) have been identified as risk factors. These risk factors (demographics and metabolic disorder) are associated with DM or OA. Other possible factors may include sleep disorders and depression. Medications for metabolic syndromes might be related to the incidence and progression of OA, with conflicting results. Given the growing body of evidence indicating a relationship between DM and OA, it is vital to analyze, interpret, and integrate these findings. Therefore, the purpose of this review was to evaluate the evidence on the prevalence, relationship, pain, and risk factors of both DM and OA. The research was limited to knee, hip, and hand OA.
C1 [Alenazi, Aqeel M.; Alhowimel, Ahmed S.; Alqahtani, Bader A.; Alhwoaimel, Norah A.] Prince Sattam Bin Abdulaziz Univ, Dept Hlth & Rehabil Sci, Alkharj 11942, Saudi Arabia.
   [Alshehri, Mohammed M.] Jazan Univ, Dept Phys Therapy, Jazan 45142, Saudi Arabia.
   [Segal, Neil A.] Univ Kansas, Dept Phys Med & Rehabil, Med Ctr, Kansas City, KS 66160 USA.
   [Kluding, Patricia M.] Univ Kansas, Dept Phys Therapy & Rehabil Sci, Med Ctr, Kansas City, KS 66160 USA.
C3 Prince Sattam Bin Abdulaziz University; Jazan University; University of
   Kansas; University of Kansas Medical Center; University of Kansas;
   University of Kansas Medical Center
RP Alenazi, AM (corresponding author), Prince Sattam Bin Abdulaziz Univ, Dept Hlth & Rehabil Sci, Alkharj 11942, Saudi Arabia.
EM aqeelalenazi.pt@gmail.com
RI alhwoaimel, norah/GXH-6759-2022; Kluding, Patricia/D-1617-2016; Alenazi,
   Aqeel/L-3102-2019; Alqahtani, Bader/V-8094-2019; Segal,
   Neil/B-2049-2008; /AAZ-6491-2020; Alshehri, Mohammed/AFM-1005-2022
OI alhwoaimel, norah/0000-0001-9448-4365; Alqahtani,
   Bader/0000-0002-8275-6906; Segal, Neil/0000-0002-8294-080X;
   /0000-0002-2936-7581; Alenazi, Aqeel/0000-0002-2641-8339; Alshehri,
   Mohammed/0000-0003-0028-0957
FU Deputyship for Research and Innovation, Ministry of Education
   [IF-PSAU-2021/03/18577]
FX This study was supported by the Deputyship for Research and Innovation,
   Ministry of Education through the project number IF-PSAU-2021/03/18577.
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NR 112
TC 14
Z9 15
U1 0
U2 7
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2075-4418
J9 DIAGNOSTICS
JI Diagnostics
PD APR
PY 2023
VL 13
IS 8
AR 1386
DI 10.3390/diagnostics13081386
PG 19
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA F0PT9
UT WOS:000979459500001
PM 37189487
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Yaseen, HS
   Zubair, HM
   Jamal, A
   Farrukh, M
   Mikrani, R
   Shaukat, B
   Hill, JW
   Rana, R
   Nazir, A
   Naveed, M
   Malik, S
AF Yaseen, Hafiza Sidra
   Zubair, Hafiz Muhammad
   Jamal, Adil
   Farrukh, Maryam
   Mikrani, Reyaj
   Shaukat, Bushra
   Hill, Jennifer W.
   Rana, Reemal
   Nazir, Ansa
   Naveed, Muhammad
   Malik, Samiullah
TI Naringin: Cardioprotective properties and safety profile in diabetes
   treatment
SO FITOTERAPIA
LA English
DT Review
DE Naringin; Hypertension; Diabetic cardiomyopathy; Toxicity
ID INDUCED MYOCARDIAL-INFARCTION; HIGH-FAT; OXIDATIVE STRESS; RATS;
   HYPERTENSION; CHOLESTEROL; DYSFUNCTION; HESPERIDIN; MEDICINE; ENZYMES
AB Flavonoids derived from plants offer a broad spectrum of therapeutic potential for addressing metabolic syndrome, particularly diabetes mellitus (DM), a prevalent non-communicable disease. Hyperglycemia in DM is a known risk factor for cardiovascular diseases (CVDs), which substantially impact global mortality rates. This review examines the potential effects of naringin, a citrus flavonoid, on both DM and its associated cardiovascular complications, including conditions like diabetic cardiomyopathy. The safety profile of naringin is summarized based on various pre-clinical studies. The data for this review was gathered from diverse electronic databases, including Medline, PubMed, ScienceDirect, SpringerLink, Google Scholar, and Emerald Insight. Multiple pre-clinical studies have demonstrated that naringin exerts hypoglycemic and cardioprotective effects by targeting various vascular mechanisms. Specifically, research indicates that naringin down-regulates the renin-angiotensin and oxidative stress systems while concurrently upregulating beta-cell and immune system functions. Clinical trial outcomes also support the therapeutic potential of naringin in managing hyperglycemic states and associated cardiovascular issues. Moreover, toxicity studies have confirmed the safety of naringin in animal models, suggesting its potential for safe administration in humans. In conclusion, naringin emerges as a promising natural candidate for both antidiabetic and cardioprotective purposes, offering potential improvements in health outcomes. While naringin presents a new avenue for therapies targeting DM and CVDs, additional controlled and long-term clinical trials are necessary to validate its efficacy and safety for human use.
C1 [Yaseen, Hafiza Sidra; Nazir, Ansa] Univ Lahore, Fac Pharm, Lahore 54000, Pakistan.
   [Zubair, Hafiz Muhammad; Malik, Samiullah] Islamia Univ Bahawalpur, Postgrad Med Coll, Fac Med & Allied Hlth Sci, Bahawalpur, Pakistan.
   [Jamal, Adil; Shaukat, Bushra; Rana, Reemal] Umm Al Qura Univ, Coll Nursing, Sci & Res, Mecca 715, Saudi Arabia.
   [Farrukh, Maryam] Univ Faisalabad, Govt Coll, Fac Pharmaceut Sci, Dept Pharmacol, Faisalabad, Pakistan.
   [Mikrani, Reyaj] China Pharmaceut Univ, Sch Basic Med & Clin Pharm, Dept Clin Pharm, Nanjing 211198, Peoples R China.
   [Hill, Jennifer W.; Naveed, Muhammad] Univ Toledo, Sch Med & Life Sci, Dept Pharmacol & Physiol, Toledo, OH 43614 USA.
C3 University of Lahore; Islamia University of Bahawalpur; Umm Al-Qura
   University; Government College University Faisalabad; China
   Pharmaceutical University; University System of Ohio; University of
   Toledo
RP Zubair, HM (corresponding author), Islamia Univ Bahawalpur, Postgrad Med Coll, Fac Med & Allied Hlth Sci, Bahawalpur, Pakistan.
EM muhammad.zubair@iub.edu.pk
RI Zubair, Hafiz Muhammad/S-5296-2019; Mikrani, Reyaj/AAM-6773-2020;
   Yaseen, Hafiza Sidra/AAV-2207-2021; Nazir, Aafaq/A-5298-2017; Hill,
   Jennifer/AAD-8415-2019; Naveed, Muhammad/Y-3856-2018
OI Naveed, Muhammad/0000-0002-2193-9266
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NR 77
TC 3
Z9 3
U1 4
U2 9
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0367-326X
EI 1873-6971
J9 FITOTERAPIA
JI Fitoterapia
PD JUL
PY 2024
VL 176
AR 106011
DI 10.1016/j.fitote.2024.106011
EA MAY 2024
PG 8
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA D2J5P
UT WOS:001294501900001
PM 38740344
DA 2025-06-11
ER

PT J
AU Sun, Y
   Zhang, LX
   Lu, BL
   Wen, JC
   Wang, MY
   Zhang, SW
   Li, QZ
   Shu, F
   Lu, FP
   Liu, N
   Peng, S
   Zhao, YJ
   Dong, SY
   Lu, FH
   Zhang, WH
   Wang, Y
AF Sun, Yu
   Zhang, Linxue
   Lu, Baoling
   Wen, Jingchen
   Wang, Mengyi
   Zhang, Shiwu
   Li, Qianzhu
   Shu, Feng
   Lu, Fangping
   Liu, Ning
   Peng, Shuo
   Zhao, Yajun
   Dong, Shiyun
   Lu, Fanghao
   Zhang, Weihua
   Wang, Yan
TI Hydrogen sulphide reduced the accumulation of lipid droplets in cardiac
   tissues of db/db mice via Hrd1 S-sulfhydration
SO JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
LA English
DT Article
DE DGAT; diabetic cardiomyopathy; Hrd1; hydrogen sulphide; Lipid droplets;
   S-sulfhydration
ID ER STRESS; DIABETIC CARDIOMYOPATHY; METABOLIC SYNDROME; HEART-FAILURE;
   PROTECTS; EXPRESSION; MANAGEMENT; AUTOPHAGY; OBESITY
AB Accumulation of lipid droplets (LDs) induces cardiac dysfunctions in type 2 diabetes patients. Recent studies have shown that hydrogen sulphide (H2S) ameliorates cardiac functions in db/db mice, but its regulation on the formation of LDs in cardiac tissues is unclear. Db/db mice were injected with NaHS (40 mu mol center dot kg(-1)) for twelve weeks. H9c2 cells were treated with high glucose (40 mmol/L), oleate (200 mu mol/L), palmitate (200 mu mol/L) and NaHS (100 mu mol/L) for 48 hours. Plasmids for the overexpression of wild-type Hrd1 and Hrd1 mutated at Cys115 were constructed. The interaction between Hrd1 and DGAT1 and DGAT2, the ubiquitylation level of DGAT1 and 2, the S-sulfhydration of Hrd1 were measured. Exogenous H2S ameliorated the cardiac functions, decreased ER stress and reduced the number of LDs in db/db mice. Exogenous H2S could elevate the ubiquitination level of DGAT 1 and 2 and increased the expression of Hrd1 in cardiac tissues of db/db mice. The S-sulfhydration of Hrd1 by NaHS enhanced the interaction between Hrd1 and DGAT1 and 2 to inhibit the formation of LD. Our findings suggested that H2S modified Hrd1 S-sulfhydration at Cys115 to reduce the accumulation of LDs in cardiac tissues of db/db mice.
C1 [Sun, Yu; Zhang, Linxue; Wen, Jingchen; Wang, Mengyi; Zhang, Shiwu; Li, Qianzhu; Shu, Feng; Lu, Fangping; Liu, Ning; Peng, Shuo; Zhao, Yajun; Dong, Shiyun; Lu, Fanghao; Zhang, Weihua] Harbin Med Univ, Dept Pathophysiol, Harbin 150086, Peoples R China.
   [Lu, Baoling] Harbin Med Univ, Hosp 4, Dept Infect, Harbin, Peoples R China.
   [Wang, Yan] Harbin Med Univ, Affiliated Hosp 1, Dept Urol Surg, Harbin 150001, Peoples R China.
C3 Harbin Medical University; Harbin Medical University; Harbin Medical
   University
RP Zhang, WH (corresponding author), Harbin Med Univ, Dept Pathophysiol, Harbin 150086, Peoples R China.; Wang, Y (corresponding author), Harbin Med Univ, Affiliated Hosp 1, Dept Urol Surg, Harbin 150001, Peoples R China.
EM zhangwh116@126.com; wy53600880@qq.com
RI Dong, Shiyun/G-7766-2012; YUXIN, ZHANG/GNH-2283-2022; zhang,
   weihua/GXV-1334-2022; wang, mengyi/KEI-9461-2024
FU National Natural Science Foundation of China [81670344, 81970317,
   81970411]
FX National Natural Science Foundation of China, Grant/Award Number:
   81670344, 81970317 and 81970411
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NR 49
TC 23
Z9 26
U1 1
U2 21
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1582-1838
EI 1582-4934
J9 J CELL MOL MED
JI J. Cell. Mol. Med.
PD OCT
PY 2021
VL 25
IS 19
BP 9154
EP 9167
DI 10.1111/jcmm.16781
EA SEP 2021
PG 14
WC Cell Biology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Research & Experimental Medicine
GA WD3SZ
UT WOS:000698965400001
PM 34562065
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Aaseth, J
   Skalny, AV
   Roos, PM
   Alexander, J
   Aschner, M
   Tinkov, AA
AF Aaseth, Jan
   Skalny, Anatoly V.
   Roos, Per M.
   Alexander, Jan
   Aschner, Michael
   Tinkov, Alexey A.
TI Copper, Iron, Selenium and Lipo-Glycemic Dysmetabolism in Alzheimer's
   Disease
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE copper; iron; glycemic dysregulation; GLP-1 agonist; advanced glycation
   end-products; selenium
ID GLYCATION END-PRODUCTS; AMYLOID-BETA-PEPTIDE; BLOOD-BRAIN-BARRIER; MILD
   COGNITIVE IMPAIRMENT; MITIGATES TAU PATHOLOGY; OXIDATIVE STRESS;
   APOLIPOPROTEIN-E; SELENOPROTEIN-P; SODIUM SELENATE; POTENTIAL ROLE
AB The aim of the present review is to discuss traditional hypotheses on the etiopathogenesis of Alzheimer's disease (AD), as well as the role of metabolic-syndrome-related mechanisms in AD development with a special focus on advanced glycation end-products (AGEs) and their role in metal-induced neurodegeneration in AD. Persistent hyperglycemia along with oxidative stress results in increased protein glycation and formation of AGEs. The latter were shown to possess a wide spectrum of neurotoxic effects including increased A beta generation and aggregation. In addition, AGE binding to receptor for AGE (RAGE) induces a variety of pathways contributing to neuroinflammation. The existing data also demonstrate that AGE toxicity seems to mediate the involvement of copper (Cu) and potentially other metals in AD pathogenesis. Specifically, Cu promotes AGE formation, AGE-A beta cross-linking and up-regulation of RAGE expression. Moreover, A beta glycation was shown to increase prooxidant effects of Cu through Fenton chemistry. Given the role of AGE and RAGE, as well as metal toxicity in AD pathogenesis, it is proposed that metal chelation and/or incretins may slow down oxidative damage. In addition, selenium (Se) compounds seem to attenuate the intracellular toxicity of the deranged tau and A beta, as well as inhibiting AGE accumulation and metal-induced neurotoxicity.
C1 [Aaseth, Jan] Innlandet Hosp Trust, Dept Res, POB 104, N-2381 Brumunddal, Norway.
   [Skalny, Anatoly V.] Sechenov Univ, IM Sechenov First Moscow State Med Univ, World Class Res Ctr Digital Biodesign & Personali, Bolshaya Pirogovskaya St 2-4, Moscow 119146, Russia.
   [Skalny, Anatoly V.] KG Razumovsky Moscow State Univ Technol & Managem, Dept Bioelementol, Zemlyanoi Val St 73, Moscow 109004, Russia.
   [Roos, Per M.] Karolinska Inst, Inst Environm Med, S-17177 Stockholm, Sweden.
   [Alexander, Jan] Norwegian Inst Publ Hlth, POB 222 Skoyen, N-0213 Oslo, Norway.
   [Aschner, Michael] Albert Einstein Coll Med, Dept Mol Pharmacol, 1300 Morris Pk Ave, Bronx, NY 10461 USA.
   [Aschner, Michael; Tinkov, Alexey A.] Sechenov Univ, Sechenov First Moscow State Med Univ, Lab Mol Dietet, Bolshaya Pirogovskaya St 2-4, Moscow 119146, Russia.
   [Tinkov, Alexey A.] Yaroslavl State Univ, Lab Ecobiomonitoring & Qual Control, Sovetskaya Str 14, Yaroslavl 150000, Russia.
C3 Innlandet Hospital Trust; Sechenov First Moscow State Medical
   University; K.G. Razumovsky Moscow State University of Technologies &
   Management the First Cossack University; Karolinska Institutet;
   Norwegian Institute of Public Health (NIPH); Montefiore Medical Center;
   Albert Einstein College of Medicine; Yeshiva University; Sechenov First
   Moscow State Medical University; Yaroslavl State University
RP Tinkov, AA (corresponding author), Sechenov Univ, Sechenov First Moscow State Med Univ, Lab Mol Dietet, Bolshaya Pirogovskaya St 2-4, Moscow 119146, Russia.; Tinkov, AA (corresponding author), Yaroslavl State Univ, Lab Ecobiomonitoring & Qual Control, Sovetskaya Str 14, Yaroslavl 150000, Russia.
EM jaol-aas@online.no; skalny3@gmail.com; per.roos@ki.se;
   jan.alexander@fhi.no; michael.aschner@einsteinmed.org;
   tinkov.a.a@gmail.com
RI Roos, Per/T-4024-2019; Skalny, Anatoly/J-3953-2019; Aschner,
   Michael/ACO-6461-2022; Tinkov, Alexey/H-5842-2016; Aaseth,
   Jan/J-6764-2017
OI Alexander, Jan/0000-0002-6381-5720; aschner,
   michael/0000-0002-2619-1656; Aaseth, Jan/0000-0002-7518-5703
FU Ministry of Science and Higher Education of the Russian Federation
   [075-15-2020-926]
FX The work was supported by the Ministry of Science and Higher Education
   of the Russian Federation within the framework of state support for the
   creation and development of World-Class Research Centers "Digital
   biodesign and personalized healthcare" No075-15-2020-926.
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NR 152
TC 40
Z9 40
U1 3
U2 25
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD SEP
PY 2021
VL 22
IS 17
AR 9461
DI 10.3390/ijms22179461
PG 19
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA UN9JR
UT WOS:000694323700001
PM 34502369
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Costa, ALB
   das Merces, MC
   Santana, AIC
   Silva, DDE
   Pimentel, RFW
   de Figueiredo, PCM
   Brandao, TS
   Coelho, JMF
   Almeida, AAE
   Damasceno, KSM
   Rossi, TRA
   de Souza, MC
   Lua, I
   da Silva, DAR
   Cerqueira, MMBF
   Gomes, AMT
   de Oliveira, JF
   de Sousa, AR
   Santana, TD
   Servo, MLS
   Marinho, MCG
   Magalhaes, LBNC
   Silva, AP
   Marques, SC
   Wolter, RMCP
   Penna, LH
   França, LCM
   Peres, EM
   Couto, PLS
   de Andrade, PCDT
   dos Santos, LFD
   Fonseca, AVG
   Santos, CS
   Gonçalves, LMD
   D'Oliveira, A
AF Brandao Costa, Andre Luiz
   das Merces, Magno Conceicao
   Costa Santana, Amalia Ivine
   e Silva, Douglas de Souza
   Weyll Pimentel, Rodrigo Fernandes
   Muniz de Figueiredo, Pedro Carlos
   Brandao, Tatiana Santos
   Freitas Coelho, Julita Maria
   e Almeida, Alex Almeida
   Meneses Damasceno, Kairo Silvestre
   Aranha Rossi, Thais Regis
   de Souza, Marcio Costa
   Lua, Iracema
   Reis da Silva, Dandara Almeida
   Borba Fonseca Cerqueira, Monique Magnavita
   Tosoli Gomes, Antonio Marcos
   de Oliveira, Jeane Freitas
   de Sousa, Anderson Reis
   Santana, Thiago da Silva
   Silva Servo, Maria Lucia
   Graca Marinho, Marcia Cristina
   Neves Cunha Magalhaes, Lucelia Batista
   Silva, Arthur Pinto
   Marques, Sergio Correa
   Coelho Pecly Wolter, Rafael Moura
   Penna, Lucia Helena
   Moraes Franca, Luiz Carlos
   Peres, Ellen Marcia
   Santos Couto, Pablo Luiz
   da Silva Thiengo de Andrade, Priscila Cristina
   de Mello dos Santos, Livia Fajin
   Gomes Fonseca, Ana Victoria
   Santos, Charles Souza
   da Silva Goncalves, Livia Maria
   D'Oliveira Junior, Argemiro
TI The Prevalence of Abdominal Adiposity among Primary Health Care
   Physicians in Bahia, Brazil: An Epidemiological Study
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Article
DE abdominal fat; health personnel; health care; body mass index;
   physicians
ID METABOLIC SYNDROME; PROGRAM; PROFILE
AB Background: Labor activities are demanding for workers and can induce occupational stress. Primary health care (PHC) workers have faced problems that can lead to the development of stress and abdominal obesity. The aim of this study was to estimate the prevalence of abdominal adiposity among primary health care physicians in the metropolitan mesoregion of Salvador, Bahia. Methods: This is a cross-sectional study conducted with physicians from the family health units (FHUs) of the metropolitan mesoregion of Salvador, Bahia, Brazil. The number of FHUs corresponded to 41 teams (52 physicians). Anamnesis was performed and a questionnaire was applied. The clinical examination consisted of measuring waist circumference (WC), blood pressure levels (BP), and body mass index (BMI), as well as examining for acanthosis nigricans. Blood samples were collected for biochemical dosages. The data obtained were analyzed by SPSS version 22.0. Results: The sample included 41 physicians (response rate: 78.8%), of which 18 were women (44.0%). The percentage of overweight participants represented by BMI was 31.7%. The hypertriglyceridemia prevalence was 29.2%. HDL-c was low in 48.7% of the participants. The waist circumference measurement revealed a prevalence of abdominal adiposity of 38.8% (women) and 34.8% (men). Conclusions: Medical professionals in PHC are more susceptible to having higher abdominal adiposity, especially female physicians.
C1 [Brandao Costa, Andre Luiz; das Merces, Magno Conceicao; Weyll Pimentel, Rodrigo Fernandes; Meneses Damasceno, Kairo Silvestre; Aranha Rossi, Thais Regis; de Souza, Marcio Costa; Reis da Silva, Dandara Almeida; Borba Fonseca Cerqueira, Monique Magnavita; Graca Marinho, Marcia Cristina; Silva, Arthur Pinto] State Univ Bahia UNEB, Dept Life Sci, BR-41150000 Salvador, BA, Brazil.
   [das Merces, Magno Conceicao; Costa Santana, Amalia Ivine; e Silva, Douglas de Souza; da Silva Goncalves, Livia Maria; D'Oliveira Junior, Argemiro] Fed Univ Bahia UFBA, Sch Med, Hlth Sci Postgrad Program, BR-40026010 Salvador, BA, Brazil.
   [Costa Santana, Amalia Ivine; Weyll Pimentel, Rodrigo Fernandes; Muniz de Figueiredo, Pedro Carlos; Brandao, Tatiana Santos] Univ Hosp Complex Prof Edgard Santos HUPES, BR-40110060 Salvador, BA, Brazil.
   [Freitas Coelho, Julita Maria] Fed Inst Educ Bahia IFBA, BR-43700000 Simoes Filho, BA, Brazil.
   [e Almeida, Alex Almeida] Transcend Clin TC, BR-41730101 Salvador, BA, Brazil.
   [Meneses Damasceno, Kairo Silvestre] Municipal Hlth Dept, BR-40010010 Salvador, BA, Brazil.
   [Lua, Iracema; Santana, Thiago da Silva; Silva Servo, Maria Lucia] State Univ Feira de Santana UEFS, Dept Hlth, BR-44036900 Feira De Santana, BA, Brazil.
   [Tosoli Gomes, Antonio Marcos; Marques, Sergio Correa; Penna, Lucia Helena; Moraes Franca, Luiz Carlos; Peres, Ellen Marcia; da Silva Thiengo de Andrade, Priscila Cristina; de Mello dos Santos, Livia Fajin] State Univ Rio de Janeiro UERJ, Sch Nursing, BR-20551030 Rio De Janeiro, RJ, Brazil.
   [de Oliveira, Jeane Freitas; de Sousa, Anderson Reis] Fed Univ Bahia EEUFBA, Sch Nursing, BR-40110060 Salvador, BA, Brazil.
   [Neves Cunha Magalhaes, Lucelia Batista] Univ Ctr UNIFTC, Med Sch, BR-41741590 Salvador, BA, Brazil.
   [Coelho Pecly Wolter, Rafael Moura] Fed Univ Espirito Santo UFES, Dept Social Psychol & Dev, BR-29075910 Vitoria, ES, Brazil.
   [Santos Couto, Pablo Luiz] FG Univ Ctr, Sch Nursing, BR-46430000 Guanambi, BA, Brazil.
   [Gomes Fonseca, Ana Victoria] Univertix Coll, Sch Adm, BR-25635416 Tres Rios, RJ, Brazil.
   [Santos, Charles Souza] Univ Southwest Bahia UESB, Hlth Dept, BR-45200000 Jequie, BA, Brazil.
C3 Universidade do Estado Bahia; Universidade Estadual de Feira de Santana;
   Universidade do Estado do Rio de Janeiro; Universidade Federal do
   Espirito Santo; Universidade Estadual do Sudoeste da Bahia
RP das Merces, MC (corresponding author), State Univ Bahia UNEB, Dept Life Sci, BR-41150000 Salvador, BA, Brazil.; das Merces, MC (corresponding author), Fed Univ Bahia UFBA, Sch Med, Hlth Sci Postgrad Program, BR-40026010 Salvador, BA, Brazil.
EM andrelbcosta@hotmail.com; mmerces@uneb.br; amalia0807@gmail.com;
   douglasss-gbi@hotmail.com; rodrigo.pimentel@ebserh.gov.br;
   pedro.figueiredo@ebserh.gov.br; tatiana.brandao@ebserh.gov.br;
   julitamaria@gmail.com; alexalmeida.a@gmail.com;
   kairodamasceno@hotmail.com; thais.aranha@gmail.com;
   mcsouzafisio@gmail.com; ira_lua@hotmail.com; daraareis@gmail.com;
   moniquemagnavita@hotmail.com; mtosoli@gmail.com;
   jeane.foliveira@outlook.com; son.reis@hotmail.com; tssantana@uefs.br;
   luciaservo@yahoo.com.br; mcmarinho@uneb.br;
   luceliamagalhaes@terra.com.br; arthurps@outlook.com.br;
   sergiocmarques@uol.com.br; rafaelpedywolter@gmail.com;
   luciapenna@terra.com.br; lcmoraesfranca@hotmail.com;
   ellenperesuerj@gmail.com; pabloluizsc@hotmail.com;
   profprithiengo@gmail.com; liviafajin@gmail.com;
   gomesanavictoria3@gmail.com; charlesss@uesb.edu.br;
   liviajeje@yahoo.com.br; argemiro@ufba.br
RI Penna, Lúcia/AEB-0451-2022; Gomes, A./Q-6844-2016; da Silva Santana,
   Thiago/ABF-1184-2020; Merces, Magno/S-6649-2017; Brandao,
   Tatiana/KIA-8022-2024; França, Luiz/AFJ-8616-2022; Cerqueira,
   Monique/HKV-5843-2023; Couto, Pablo/LUZ-7668-2024; de Sousa,
   Anderson/AAU-7163-2021; Lua, Iracema/AAR-2466-2021; MAGALHÃES,
   LUCELIA/AAA-1378-2019; Silva Thiengo de Andrade, Priscila
   Cristina/AAE-8949-2022; Costa de Souza, Marcio/Y-8859-2018
OI MORAES FRANCA, LUIZ CARLOS/0000-0002-6370-115X; REIS DE SOUSA,
   ANDERSON/0000-0001-8534-1960; Coelho, Julita/0000-0002-9520-5177;
   Cerqueira, Monique/0000-0002-9836-7788; Pimentel, Rodrigo Fernandes
   Weyll/0000-0003-0101-0190; Silvestre Meneses Damasceno,
   Kairo/0000-0002-2444-4496; Merces, Magno Conceicao
   das/0000-0003-3493-8606; Pinto Silva, Arthur/0000-0001-9588-9196; Silva
   Thiengo de Andrade, Priscila Cristina/0000-0003-0840-4838; Santana,
   Thiago/0000-0003-0987-0814; Santos, Charles Souza/0000-0001-5071-0359;
   Costa de Souza, Marcio/0000-0002-4922-6786
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NR 41
TC 1
Z9 1
U1 0
U2 1
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD FEB
PY 2021
VL 18
IS 3
AR 957
DI 10.3390/ijerph18030957
PG 10
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA QD0MU
UT WOS:000615223500001
PM 33499303
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Chen, HY
   White, E
AF Chen, Hsin-Yi
   White, Eileen
TI Role of Autophagy in Cancer Prevention
SO CANCER PREVENTION RESEARCH
LA English
DT Review
ID TRANSCRIPTION FACTOR NRF2; BETA-CELL MASS; LIFE-SPAN; P62; PROTEIN;
   MICE; DEGRADATION; DISEASE; PHOSPHORYLATION; STRESS
AB Macroautophagy (autophagy hereafter) is a catabolic process by which cells degrade intracellular components in lysosomes. This cellular garbage disposal and intracellular recycling system maintains cellular homeostasis by eliminating superfluous or damaged proteins and organelles and invading microbes and by providing substrates for energy generation and biosynthesis in stress. Autophagy thus promotes the health of cells and animals and is critical for the development, differentiation, and maintenance of cell function and for the host defense against pathogens. Deregulation of autophagy is linked to susceptibility to various disorders including degenerative diseases, metabolic syndrome, aging, infectious diseases, and cancer. Autophagic activity emerges as a critical factor in the development and progression of diseases that are associated with increased cancer risk as well as in different stages of cancer. Given that cancer is a complex process and autophagy exerts its effects in multiple ways, the role of autophagy in tumorigenesis is context-dependent. As a cytoprotective survival pathway, autophagy prevents chronic tissue damage that can lead to cancer initiation and progression. In this setting, stimulation or restoration of autophagy may prevent cancer. In contrast, once cancer occurs, many cancer cells upregulate basal autophagy and utilize autophagy to enhance fitness and survive in the hostile tumor microenvironment. These findings revealed the concept that aggressive cancers can be addicted to autophagy for survival. In this setting, autophagy inhibition is a therapeutic strategy for established cancers. Cancer Prev Res; 4(7); 973-83. (C)2011 AACR.
C1 [Chen, Hsin-Yi; White, Eileen] Canc Inst New Jersey, New Brunswick, NJ 08903 USA.
   [Chen, Hsin-Yi; White, Eileen] Rutgers State Univ, Dept Mol Biol & Biochem, Piscataway, NJ 08855 USA.
   [White, Eileen] Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Piscataway, NJ 08854 USA.
C3 Rutgers University System; Rutgers University New Brunswick; Rutgers
   University Biomedical & Health Sciences; Rutgers Cancer Institute of New
   Jersey; Rutgers University System; Rutgers University New Brunswick;
   Rutgers University System; Rutgers University New Brunswick; Rutgers
   University Biomedical & Health Sciences
RP White, E (corresponding author), Canc Inst New Jersey, 195 Little Albany St, New Brunswick, NJ 08903 USA.
EM whiteei@umdnj.edu
RI White, Eileen/ABD-6745-2021
OI White, Eileen/0000-0003-2961-3065
FU Pfizer; Johnson Johnson; U.S. NIH [R37 CA53370, R01 CA130893, RC1
   CA147961]; New Jersey Commission on Cancer Research [09-1083-CCR-EO];
   U.S. Department of Defense [W81XWH06-1-0514, W81XWH05]
FX E. White has received research support from Pfizer and Johnson & Johnson
   for projects not discussed to the content of this review. No potential
   conflicts of interest were disclosed.E. White was supported by the U.S.
   NIH (R37 CA53370, R01 CA130893, and RC1 CA147961), New Jersey Commission
   on Cancer Research (09-1083-CCR-EO), and U.S. Department of Defense
   (W81XWH06-1-0514 and W81XWH05).
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NR 81
TC 153
Z9 176
U1 0
U2 16
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 1940-6207
EI 1940-6215
J9 CANCER PREV RES
JI Cancer Prev. Res.
PD JUL
PY 2011
VL 4
IS 7
BP 973
EP 983
DI 10.1158/1940-6207.CAPR-10-0387
PG 11
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA 788MN
UT WOS:000292449200005
PM 21733821
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Habobe, HAL
   Pieters, RHH
   Bikker, FJ
AF Habobe, H. al
   Pieters, R. H. H.
   Bikker, F. J.
TI Investigating the Salivary Biomarker Profile in Obesity: A Systematic
   Review
SO CURRENT OBESITY REPORTS
LA English
DT Review
DE Obesity; Saliva; Biomarkers; Metabolic syndrome; MUO
ID NECROSIS-FACTOR-ALPHA; INSULIN-RESISTANCE; PROTEIN; INFLAMMATION;
   PLASMA; DYSFUNCTION; STRESS; WOMEN
AB Purpose of Review This systematic review aims to map the existing literature on salivary biomarkers in adults with metabolically unhealthy obesity (MUO), identify key biomarkers associated with this high-risk group, and highlight areas requiring further research to advance this emerging field. Recent Findings Obesity is characterized by an abnormal accumulation of body fat and chronic inflammation. However, not all individuals with obesity experience metabolic dysfunction. This review focuses on MUO, which is strongly linked to metabolic disorders such as insulin resistance, cardiovascular disease, type 2 diabetes, and systemic inflammation. Linking MUO and salivary biomarkers may enhance our understanding of how systemic health influences salivary composition and could enable the early identification of high-risk individuals through non-invasive saliva testing. This review synthesized findings from recent studies and identified key salivary biomarkers consistently elevated in individuals with MUO, including 8-OHdG, IL-6, IL-8, resistin, TNFR1, PTX-3, AEA, OEA, TNF-alpha, and sICAM-1. These biomarkers are associated with inflammation, oxidative stress, and metabolic dysregulation. The majority of studies utilized cross-sectional designs and used various saliva collection methods. Summary Salivary biomarkers hold promise as non-invasive indicators of obesity-related metabolic dysfunction, particularly in MUO. However, their clinical diagnostic utility remains uncertain due to heterogeneity in study designs, a lack of biomarker validation, and limited longitudinal studies. Further research is needed to establish their bona fide diagnostic potential.
C1 [Habobe, H. al; Pieters, R. H. H.] Univ Appl Sci Utrecht, Res Ctr Hlth & Sustainable Living, Res Grp Innovat Testing Life Sci & Chem, Utrecht, Netherlands.
   [Habobe, H. al; Pieters, R. H. H.] Univ Utrecht, Inst Risk Assessment Sci, Fac Vet Med, Utrecht, Netherlands.
   [Habobe, H. al; Bikker, F. J.] Univ Amsterdam, Acad Ctr Dent Amsterdam ACTA, Dept Oral Biochem, Amsterdam, Netherlands.
   [Habobe, H. al; Bikker, F. J.] Vrije Univ Amsterdam, Amsterdam, Netherlands.
C3 Utrecht University; Academic Center for Dentistry Amsterdam; University
   of Amsterdam; Vrije Universiteit Amsterdam; Vrije Universiteit Amsterdam
RP Habobe, HAL (corresponding author), Univ Appl Sci Utrecht, Res Ctr Hlth & Sustainable Living, Res Grp Innovat Testing Life Sci & Chem, Utrecht, Netherlands.; Habobe, HAL (corresponding author), Univ Utrecht, Inst Risk Assessment Sci, Fac Vet Med, Utrecht, Netherlands.; Habobe, HAL (corresponding author), Univ Amsterdam, Acad Ctr Dent Amsterdam ACTA, Dept Oral Biochem, Amsterdam, Netherlands.; Habobe, HAL (corresponding author), Vrije Univ Amsterdam, Amsterdam, Netherlands.
EM hanan.alhabobe@hu.nl
RI Bikker, Floris/R-1941-2019
OI Bikker, Floris/0000-0002-9453-4630
FU Health~Holland; Health-Holland, Topsector Life Sciences Health
FX The study was financially supported by Health-Holland, Topsector Life
   Sciences & Health.
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NR 69
TC 0
Z9 0
U1 2
U2 2
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 2162-4968
J9 CURR OBES REP
JI Curr. Obes. Rep.
PD MAR 28
PY 2025
VL 14
IS 1
AR 25
DI 10.1007/s13679-025-00618-y
PG 15
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 0TX6I
UT WOS:001455929900003
PM 40153192
DA 2025-06-11
ER

PT J
AU Zhu, JW
   He, L
AF Zhu, Junwen
   He, Lan
TI The Modulatory Effects of Curcumin on the Gut Microbiota: A Potential
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SO MICROORGANISMS
LA English
DT Review
DE curcumin; gut microbiota; inflammation; oxidative stress;
   bioavailability; Intestinal barrier; health
ID NF-KAPPA-B; FATTY LIVER-DISEASE; ALKALINE-PHOSPHATASE; COLONIC
   MICROBIOTA; METABOLIC SYNDROME; OXIDATIVE STRESS; DIETARY CURCUMIN;
   GENE-EXPRESSION; IMMUNE-SYSTEM; IN-VITRO
AB Curcumin (CUR) is a lipophilic natural polyphenol that can be isolated from the rhizome of turmeric. Studies have proposed that CUR possesses a variety of biological activities. Due to its anti-inflammatory and antioxidant properties, CUR shows promise in the treatment of inflammatory bowel disease, while its anti-obesity effects make it a potential therapeutic agent in the management of obesity. In addition, curcumin's ability to prevent atherosclerosis and its cardiovascular benefits further expand its potential application in the treatment of cardiovascular disease. Nevertheless, owing to the limited bioavailability of CUR, it is difficult to validate its specific mechanism of action in the treatment of diseases. However, the restricted bioavailability of CUR makes it challenging to confirm its precise mode of action in disease treatment. Recent research indicates that the oral intake of curcumin may lead to elevated levels of residual curcumin in the gastrointestinal system, hinting at curcumin's potential to directly influence gut microbiota. Furthermore, the ecological dysregulation of the gut microbiota has been shown to be critical in the pathogenesis of human diseases. This review summarizes the impact of gut dysbiosis on host health and the various ways in which curcumin modulates dysbiosis and ameliorates various diseases caused by it through the administration of curcumin.
C1 [Zhu, Junwen; He, Lan] Hunan Agr Univ, Coll Biosci & Biotechnol, Changsha 410128, Peoples R China.
C3 Hunan Agricultural University
RP Zhu, JW (corresponding author), Hunan Agr Univ, Coll Biosci & Biotechnol, Changsha 410128, Peoples R China.
EM rosyz@stu.hunau.edu.cn; helan@stu.hunau.edu.cn
FU Hunan Provincial Science and Technology Department
FX The authors are especially grateful to Gang Liu in College of Bioscience
   and Biotechnology, Hunan Agricultural University, for his helpful
   guidance on the manuscript. The authors acknowledges www.biorender.com
   as a tool used for making the figures.
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NR 153
TC 7
Z9 7
U1 11
U2 28
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-2607
J9 MICROORGANISMS
JI Microorganisms
PD APR
PY 2024
VL 12
IS 4
AR 642
DI 10.3390/microorganisms12040642
PG 18
WC Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Microbiology
GA OV4C1
UT WOS:001210031300001
PM 38674587
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Camacho-Castillo, L
   Phillips-Farfan, BV
   Rosas-Mendoza, G
   Baires-López, A
   Toral-Ríos, D
   Campos-Peña, V
   Carvajal, K
AF Camacho-Castillo, Luz
   Phillips-Farfan, Bryan, V
   Rosas-Mendoza, Gabriela
   Baires-Lopez, Aidee
   Toral-Rios, Danira
   Campos-Pena, Victoria
   Carvajal, Karla
TI Increased oxidative stress contributes to enhance brain amyloidogenesis
   and blunts energy metabolism in sucrose-fed rat: effect of AMPK
   activation
SO SCIENTIFIC REPORTS
LA English
DT Article
ID TRANSGENIC MOUSE MODEL; ALZHEIMERS-DISEASE; INSULIN-RESISTANCE;
   CREATINE-KINASE; AMYLOID-BETA; DIET; DYSFUNCTION; OBESE;
   HYPERTRIGLYCERIDEMIA; HIPPOCAMPUS
AB Metabolic disturbances are linked to neurodegenerative diseases such as Alzheimer disease (AD). However, the cellular mechanisms underlying this connection are unclear. We evaluated the role of oxidative stress (OS), during early metabolic syndrome (MetS), on amyloidogenic processes in a MetS rat model induced by sucrose. MetS caused OS damage as indicated by serum and hypothalamus lipid peroxidation and elevated serum catalase activity. Tissue catalase and superoxide dismutase activity were unchanged by MetS, but gene expression of nuclear factor erythroid-derived 2-like 2 (NFE2L2), which up-regulates expression of antioxidant enzymes, was higher. Expression of amyloid-beta cleaving enzyme 1 (BACE-1) and amyloid precursor protein (APP), key proteins in the amyloidogenesis pathway, were slightly increased by sucrose-intake in the hippocampus and hypothalamus. Activation and expression of protein kinase B (PKB) and AMP-dependent protein kinase (AMPK), pivotal proteins in metabolism and energy signaling, were similarly affected in the hippocampus and hypothalamus of MetS rats. Brain creatine kinase activity decreased in brain tissues from rats with MetS, mainly due to irreversible oxidation. Chronic metformin administration partially reversed oxidative damage in sucrose-fed animals, together with increased AMPK activation; probably by modulating BACE-1 and NFE2L2. AMPK activation may be considered as a preventive therapy for early MetS and associated neurodegenerative diseases.
C1 [Camacho-Castillo, Luz; Phillips-Farfan, Bryan, V; Rosas-Mendoza, Gabriela; Baires-Lopez, Aidee; Carvajal, Karla] Inst Nacl Pediat, Lab Nutr Expt, Insurgentes Sur 3700 C, Del Coyoacan 04530, Cd Mexico, Mexico.
   [Toral-Rios, Danira; Campos-Pena, Victoria] Inst Nacl Neurol & Neurocirugia Manuel Velasco, Lab Expt Enfermedades Neurodegenerat, Cd Mexico, Mexico.
RP Carvajal, K (corresponding author), Inst Nacl Pediat, Lab Nutr Expt, Insurgentes Sur 3700 C, Del Coyoacan 04530, Cd Mexico, Mexico.
EM karla_ca@yahoo.com
RI del Carmen Camacho Castillo, Luz/AAX-6892-2021; CAMPOS-PEÑA,
   VICTORIA/AAR-6968-2021; Toral-Rios, Danira/J-7671-2018
OI Toral-Rios, Danira/0000-0001-5156-6969; Phillips-Farfan,
   Bryan/0000-0001-6470-6860
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NR 56
TC 13
Z9 13
U1 0
U2 10
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD OCT 1
PY 2021
VL 11
IS 1
AR 19547
DI 10.1038/s41598-021-98983-w
PG 13
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA WA2WZ
UT WOS:000702752900071
PM 34599229
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Pinteric, M
   Podgorski, II
   Hadzija, MP
   Bujak, IT
   Tadijan, A
   Balog, T
   Sobocanec, S
AF Pinteric, Marija
   Podgorski, Iva I.
   Popovic Hadzija, Marijana
   Tartaro Bujak, Ivana
   Tadijan, Ana
   Balog, Tihomir
   Sobocanec, Sandra
TI Chronic High Fat Diet Intake Impairs Hepatic Metabolic Parameters in
   Ovariectomized Sirt3 KO Mice
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE sirtuin 3; ovariectomy; high fat diet; fatty liver
ID ACID OXIDATION; SEX-DIFFERENCES; LIVER; GENE; DISEASE; OBESITY; CYP2E1;
   DESATURASE; MECHANISMS; STEATOSIS
AB High fat diet (HFD) is an important factor in the development of metabolic diseases, with liver as metabolic center being highly exposed to its influence. However, the effect of HFD-induced metabolic stress with respect to ovary hormone depletion and sirtuin 3 (Sirt3) is not clear. Here we investigated the effect of Sirt3 in liver of ovariectomized and sham female mice upon 10 weeks of feeding with standard-fat diet (SFD) or HFD. Liver was examined by Folch, gas chromatography and lipid hydroperoxide analysis, histology and oil red staining, RT-PCR, Western blot, antioxidative enzyme and oxygen consumption analyses. In SFD-fed WT mice, ovariectomy increased Sirt3 and fatty acids synthesis, maintained mitochondrial function, and decreased levels of lipid hydroperoxides. Combination of ovariectomy and Sirt3 depletion reduced ppar alpha, Scd-1 ratio, MUFA proportions, CII-driven respiration, and increased lipid damage. HFD compromised CII-driven respiration and activated peroxisomal ROS scavenging enzyme catalase in sham mice, whereas in combination with ovariectomy and Sirt3 depletion, increased body weight gain, expression of NAFLD- and oxidative stress-inducing genes, and impaired response of antioxidative system. Overall, this study provides evidence that protection against harmful effects of HFD in female mice is attributed to the combined effect of female sex hormones and Sirt3, thus contributing to preclinical research on possible sex-related therapeutic agents for metabolic syndrome and associated diseases.
C1 [Pinteric, Marija; Podgorski, Iva I.; Popovic Hadzija, Marijana; Tadijan, Ana; Balog, Tihomir; Sobocanec, Sandra] Rudjer Boskovic Inst, Div Mol Med, Zagreb 10000, Croatia.
   [Tartaro Bujak, Ivana] Rudjer Boskovic Inst, Div Mat Chem, Zagreb 10000, Croatia.
C3 Rudjer Boskovic Institute; Rudjer Boskovic Institute
RP Sobocanec, S (corresponding author), Rudjer Boskovic Inst, Div Mol Med, Zagreb 10000, Croatia.
EM mpinter@irb.hr; iskrinj@irb.hr; mhadzija@irb.hr; itartaro@irb.hr;
   Ana.Tadijan@irb.hr; balog@irb.hr; ssoboc@irb.hr
RI Hadzija, Marijana/AAV-6519-2021; Tadijan, Ana/AAM-6369-2021; Tartaro
   Bujak, Ivana/AAF-3528-2019; Sobocanec, Sandra/AAP-1416-2020; Skrinjar,
   Iva/K-8977-2017
OI Sobocanec, Sandra/0000-0001-8915-6009; Pinteric,
   Marija/0000-0003-1049-0237; Popovic Hadzija,
   Marijana/0000-0001-6522-3721; Tadijan, Ana/0000-0002-5487-3611; Tartaro
   Bujak, Ivana/0000-0002-1396-164X; Podgorski, Iva/0000-0002-9423-9711
FU Croatian Science Foundation (HRZZ) [IP-2014-09-4533]
FX This research was funded by the Croatian Science Foundation (HRZZ),
   Grant no. [IP-2014-09-4533] "SuMERA".
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NR 53
TC 8
Z9 8
U1 1
U2 10
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD APR
PY 2021
VL 22
IS 8
AR 4277
DI 10.3390/ijms22084277
PG 17
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA RT3IM
UT WOS:000644355900001
PM 33924115
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Marin, V
   Gazzin, S
   Gambaro, SE
   Dal Ben, M
   Calligaris, S
   Anese, M
   Raseni, A
   Avellini, C
   Giraudi, PJ
   Tiribelli, C
   Rosso, N
AF Marin, Veronica
   Gazzin, Silvia
   Gambaro, Sabrina E.
   Dal Ben, Matteo
   Calligaris, Sonia
   Anese, Monica
   Raseni, Alan
   Avellini, Claudio
   Giraudi, Pablo J.
   Tiribelli, Claudio
   Rosso, Natalia
TI Effects of Oral Administration of Silymarin in a Juvenile Murine Model
   of Non-alcoholic Steatohepatitis
SO NUTRIENTS
LA English
DT Article
DE NAFLD; NASH; fibrosis; silymarin; in vivo model; in vitro model;
   therapeutic approach
ID FATTY LIVER-DISEASE; MILK THISTLE; SILYBUM-MARIANUM; LIFE-STYLE;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; NILE-RED; PHARMACOLOGY;
   INFLAMMATION; CHILDREN
AB The increasing prevalence of non-alcoholic fatty liver disease (NAFLD) in adolescents is challenging the global care system. No therapeutic strategies have been defined so far, and changes in the lifestyle remain the only alternative. In this study, we assessed the protective effects of silymarin in a juvenile non-alcoholic steatohepatitis (NASH) model and the in vitro effects on fat-laden human hepatocytes. C57Bl/6 mice were exposed to HFHC diet immediately after weaning. After eight weeks, animals showed histological signs of NASH. Silymarin was added to the HFHC diet, the treatment continued for additional 12 weeks and the effects on BMI, hepatomegaly, visceral fat, lipid profile, transaminases, HOMA-IR, steatosis, inflammation, fibrosis, oxidative stress, and apoptosis were determined. The switch from HFHC to control diet was used to mimic lifestyle changes. In vitro experiments were performed in parallel in human hepatocytes. HFHC diet supplemented with silymarin showed a significant improvement in glycemia, visceral fat, lipid profile, and liver fibrosis. Moreover, it reduced (both in vitro and in vivo) ALT, hepatic inflammation, oxidative stress, and apoptosis. Lifestyle changes restored the control group parameters. The data presented show the beneficial effects of the oral administration of silymarin in the absence of changes in the dietary habits in a juvenile model of NASH.
C1 [Marin, Veronica; Gazzin, Silvia; Gambaro, Sabrina E.; Dal Ben, Matteo; Giraudi, Pablo J.; Tiribelli, Claudio; Rosso, Natalia] Ctr Studi Fegato, Fdn Italiana Fegato ONLUS, Area Sci Pk Basovizza Bldg,Q SS 14 Km 163,5, I-34149 Trieste, Italy.
   [Calligaris, Sonia; Anese, Monica] Univ Udine, Dipartimento Sci AgroAlimentari Ambientali & Anim, Via Sondrio 2-A, I-33100 Udine, Italy.
   [Raseni, Alan] IRCCS Burlo Garofolo Paediat Hosp, Clin Chem Lab, I-34100 Trieste, Italy.
   [Avellini, Claudio] Azienda Osped Univ Santa Maria della Misericordia, Ist Anat Patol, Dipartimento Lab, I-33100 Udine, Italy.
C3 University of Udine; IRCCS Burlo Garofolo; Hospital Santa Maria della
   Misericordia
RP Rosso, N (corresponding author), Ctr Studi Fegato, Fdn Italiana Fegato ONLUS, Area Sci Pk Basovizza Bldg,Q SS 14 Km 163,5, I-34149 Trieste, Italy.
EM veronica.marin@fegato.it; silvia.gazzin@fegato.it;
   sabrigambaro@gmail.com; mdalben@fegato.it; sonia.calligaris@uniud.it;
   monica.anese@uniud.it; alan_ciop@yahoo.it;
   claudio.avellini@asuiud.sanita.fvg.it; pablo.giraudi@fegato.it;
   ctliver@fegato.it; natalia.rosso@fegato.it
RI Dal Ben, Matteo/N-6658-2015; Rosso, Natalia/K-9035-2016; Tiribelli,
   Claudio/A-4716-2014
OI Dal Ben, Matteo/0000-0001-9294-2107; Rosso, Natalia/0000-0002-4251-3547;
   Tiribelli, Claudio/0000-0001-6596-7595
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NR 67
TC 33
Z9 33
U1 1
U2 14
PU MDPI AG
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 2072-6643
J9 NUTRIENTS
JI Nutrients
PD SEP
PY 2017
VL 9
IS 9
AR 1006
DI 10.3390/nu9091006
PG 20
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA FI4UM
UT WOS:000411973200089
PM 28895929
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Marney, AM
   Brown, NJ
AF Marney, Annis M.
   Brown, Nancy J.
TI Aldosterone and end-organ damage
SO CLINICAL SCIENCE
LA English
DT Review
DE aldosterone; angiotensin II (AngII); cardiovascular remodelling;
   end-organ damage; mineralocorticoid receptor; renal injury;
   renin-angiotensin-aldosterone system (RAAS)
ID PLASMINOGEN-ACTIVATOR INHIBITOR-1; ANGIOTENSIN-CONVERTING-ENZYME;
   LEFT-VENTRICULAR DYSFUNCTION; CONGESTIVE-HEART-FAILURE; TYPE-2
   DIABETES-MELLITUS; NITRIC-OXIDE SYNTHASE; MINERALOCORTICOID RECEPTOR;
   OXIDATIVE STRESS; GENE-EXPRESSION; PROTEIN-KINASE
AB Aldosterone concentrations are inappropriately high in many patients with hypertension, as well as in an increasing number of individuals with metabolic syndrome and sleep apnoea. A growing body of evidence suggests that aldosterone and/or activation of the MR (mineralocorticoid receptor) contributes to cardiovascular remodelling and renal injury in these conditions. In addition to causing sodium retention and increased blood pressure, MR activation induces oxidative stress, endothelial dysfunction, inflammation and subsequent fibrosis. The MR may be activated by aldosterone and cortisol or via transactivation by the AT, (angiotenin 11 type 1) receptor through a mechanism involving the EGFR (epidermal growth factor receptor) and MAPK (mitogen-activated protein kinase) pathway. In addition, aldosterone can generate rapid non-genomic effects in the heart and vasculature. MR antagonism reduces mortality in patients with CHIF (congestive heart failure) and following myocardial infarction. MR antagonism improves endothelial function in patients with CHF, reduces circulating biomarkers of cardiac fibrosis in CHIF or following myocardial infarction, reduces blood pressure in resistant hypertension and decreases albuminuria in hypertensive and diabetic patients. In contrast, whereas adrenalectomy improves glucose homoeostasis in hyperaldosteronism, MR antagonism may worsen glucose homoeostasis and impairs endothelial function in diabetes, suggesting a possible detrimental effect of aldosterone via non-genomic pathways.
C1 Vanderbilt Univ, Med Ctr, Dept Med, Div Clin Pharmacol, Nashville, TN 37232 USA.
   Vanderbilt Univ, Med Ctr, Dept Pharmacol, Nashville, TN 37232 USA.
C3 Vanderbilt University; Vanderbilt University
RP Brown, NJ (corresponding author), Vanderbilt Univ, Med Ctr, Dept Med, Div Clin Pharmacol, 550 Robinson Res Bldg, Nashville, TN 37232 USA.
EM Nancy.j.brown@vanderbilt.edu
FU NHLBI NIH HHS [HL067308, HL060906, HL 077389] Funding Source: Medline
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NR 130
TC 183
Z9 199
U1 0
U2 11
PU PORTLAND PRESS LTD
PI LONDON
PA 5TH FLR, 90 HIGH HOLBORN, LONDON WC1V 6LJ, ENGLAND
SN 0143-5221
EI 1470-8736
J9 CLIN SCI
JI Clin. Sci.
PD SEP
PY 2007
VL 113
IS 5-6
BP 267
EP 278
DI 10.1042/CS20070123
PG 12
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 210QW
UT WOS:000249471700006
PM 17683282
DA 2025-06-11
ER

PT J
AU Lin, CE
   Chung, CH
   Cheng, LF
   Chien, WC
AF Lin, Ching-En
   Chung, Chi-Hsiang
   Cheng, Li-Fen
   Chien, Wu-Chien
TI Increased risk for venous thromboembolism among patients with concurrent
   depressive, bipolar, and schizophrenic disorders
SO GENERAL HOSPITAL PSYCHIATRY
LA English
DT Article
DE Bipolar disorder; Depression; Deep vein thrombosis; Pulmonary embolism;
   Schizophrenia
ID DEEP-VEIN THROMBOSIS; POPULATION-BASED COHORT; METABOLIC SYNDROME;
   PULMONARY-EMBOLISM; DIABETES-MELLITUS; CIGARETTE-SMOKING;
   MENTAL-ILLNESS; DRUG-USE; OBESITY; PEOPLE
AB Objective: The study aim was to investigate the risk of venous thromboembolism (VTE) in patients with concurrent depressive, bipolar, and schizophrenic disorders.
   Methods: A population-based cohort study was conducted in which information regarding psychiatric illnesses and medical comorbidities in 29,467 patients with concurrent depressive, bipolar, and schizophrenic disorders and regarding 117,868 controls were extracted. We compared the incidence of VTE between the study and control cohorts. Cox proportional hazard regression models were used to analyze the risk of VTE after adjusting for potential confounders, including sex, age, and comorbidities.
   Results: Compared with the control cohort, the overall study cohort had a 2.995-fold higher adjusted hazard ratio (aHR) for development of deep vein thrombosis (DVT) and a 2.591-fold higher aHR for development of pulmonary embolism (PE). Moreover, patients with depressive, bipolar, and schizophrenic disorders all exhibited higher aHRs for development of both DVT and PE.
   Conclusion: The relative risks of DVT and PE were higher in patients with concurrent depressive, bipolar, and schizophrenic disorders than those of the general population. Further research is needed to develop effective prevention strategies for different patient populations.
C1 [Lin, Ching-En] Taipei Tzu Chi Hosp, Buddhist Tzu Chi Med Fdn, Dept Psychiat, New Taipei, Taiwan.
   [Lin, Ching-En] Tzu Chi Univ, Sch Med, Hualien, Taiwan.
   [Chien, Wu-Chien] Natl Def Med Ctr, Grad Inst Life Sci, Taipei, Taiwan.
   [Chung, Chi-Hsiang; Chien, Wu-Chien] Triserv Gen Hosp, Natl Def Med Ctr, Dept Med Res, Taipei, Taiwan.
   [Chung, Chi-Hsiang; Chien, Wu-Chien] Taiwanese Injury Prevent & Safety Promot Assoc, Taipei, Taiwan.
   [Chung, Chi-Hsiang; Chien, Wu-Chien] Natl Def Med Ctr, Sch Publ Hlth, Taipei, Taiwan.
   [Cheng, Li-Fen] Hualien Armed Forces Gen Hosp, Dept Psychiat, Hualien, Taiwan.
   [Cheng, Li-Fen] Natl Def Med Ctr, Sch Med, Taipei, Taiwan.
C3 Buddhist Tzu Chi General Hospital; Taipei Tzu Chi Hospital; Tzu Chi
   University; National Defense Medical Center; Tri-Service General
   Hospital; National Defense Medical Center; National Defense Medical
   Center; National Defense Medical Center
RP Chien, WC (corresponding author), Triserv Gen Hosp, Dept Med Res, 325,Sect 2,Chenggong Rd, Taipei 11490, Taiwan.
EM chienwu@mail.ndmctsgh.edu.tw
RI Chung, Chi-Hsiang/AAY-3386-2021; Lin, Ching-En/CAA-0084-2022
FU Tri-Service General Hospital Research Foundation [TSGH-C108-003]
FX This study was supported in part by the Tri-Service General Hospital
   Research Foundation (TSGH-C108-003). The funding agency did not
   influence the study design, data collection and analysis, decision to
   publish, or preparation of the manuscript.
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NR 60
TC 24
Z9 25
U1 0
U2 2
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0163-8343
EI 1873-7714
J9 GEN HOSP PSYCHIAT
JI Gen. Hosp. Psych.
PD NOV-DEC
PY 2019
VL 61
BP 34
EP 40
DI 10.1016/j.genhosppsych.2019.10.003
PG 7
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA JN5DR
UT WOS:000496919500005
PM 31710856
DA 2025-06-11
ER

PT J
AU Monteiro-Alfredo, T
   Macedo, MLR
   Souza, KD
   Matafome, P
AF Monteiro-Alfredo, Tamaeh
   Macedo, Maria Ligia Rodrigues
   Souza, Kely de Picoli
   Matafome, Paulo
TI New Therapeutic Strategies for Obesity and Its Metabolic Sequelae:
   Brazilian Cerrado as a Unique Biome
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE phytochemical compounds; secondary metabolites; metabolic diseases;
   ethnopharmacology; Cerrado ecosystem
ID EUGENIA-DYSENTERICA DC.; BODY-FAT DISTRIBUTION; DIPTERYX-ALATA VOG.;
   FLEXUOSA L. F; NF-KAPPA-B; OXIDATIVE STRESS; PHENOLIC-COMPOUNDS;
   IN-VIVO; HYDROETHANOLIC EXTRACT; CHEMICAL-COMPOSITION
AB Brazil has several important biomes holding impressive fauna and flora biodiversity. Cerrado being one of the richest ones and a significant area in the search for new plant-based products, such as foods, cosmetics, and medicines. The therapeutic potential of Cerrado plants has been described by several studies associating ethnopharmacological knowledge with phytochemical compounds and therapeutic effects. Based on this wide range of options, the Brazilian population has been using these medicinal plants (MP) for centuries for the treatment of various health conditions. Among these, we highlight metabolic diseases, namely obesity and its metabolic alterations from metabolic syndrome to later stages such as type 2 diabetes (T2D). Several studies have shown that adipose tissue (AT) dysfunction leads to proinflammatory cytokine secretion and impaired free fatty acid (FFA) oxidation and oxidative status, creating the basis for insulin resistance and glucose dysmetabolism. In this scenario, the great Brazilian biodiversity and a wide variety of phytochemical compounds make it an important candidate for the identification of pharmacological strategies for the treatment of these conditions. This review aimed to analyze and summarize the current literature on plants from the Brazilian Cerrado that have therapeutic activity against obesity and its metabolic conditions, reducing inflammation and oxidative stress.
C1 [Monteiro-Alfredo, Tamaeh; Matafome, Paulo] Univ Coimbra, Coimbra Inst Clin & Biomed Res iCBR, Fac Med, P-3000548 Coimbra, Portugal.
   [Monteiro-Alfredo, Tamaeh; Matafome, Paulo] Univ Coimbra, Ctr Innovat Biomed & Biotechnol CIBB, P-3000548 Coimbra, Portugal.
   [Monteiro-Alfredo, Tamaeh; Matafome, Paulo] Clin Acad Ctr Coimbra, P-3000075 Coimbra, Portugal.
   [Monteiro-Alfredo, Tamaeh; Souza, Kely de Picoli] Fed Univ Grande Dourados, Res Grp Biotechnol & Bioprospect Appl Metab & Canc, BR-79804970 Dourados, MS, Brazil.
   [Monteiro-Alfredo, Tamaeh; Macedo, Maria Ligia Rodrigues] Univ Fed Mato Grosso do Sul, Lab Purificacao Prot & Suas Funcoes Biol LPPFB, BR-79070900 Campo Grande, MS, Brazil.
   [Matafome, Paulo] Polytech Univ Coimbra, Coimbra Hlth Sch ESTeSC, Rua 5 Outubro, P-3046854 Coimbra, Portugal.
C3 Universidade de Coimbra; Universidade de Coimbra; Universidade de
   Coimbra; Universidade Federal da Grande Dourados; Universidade Federal
   de Mato Grosso do Sul
RP Matafome, P (corresponding author), Univ Coimbra, Coimbra Inst Clin & Biomed Res iCBR, Fac Med, P-3000548 Coimbra, Portugal.; Matafome, P (corresponding author), Univ Coimbra, Ctr Innovat Biomed & Biotechnol CIBB, P-3000548 Coimbra, Portugal.; Matafome, P (corresponding author), Clin Acad Ctr Coimbra, P-3000075 Coimbra, Portugal.; Matafome, P (corresponding author), Polytech Univ Coimbra, Coimbra Hlth Sch ESTeSC, Rua 5 Outubro, P-3046854 Coimbra, Portugal.
EM tamaehamonteiro@hotmail.com; ligiamacedo18@gmail.com;
   kelypicoli@gmail.com; paulo.matafome@uc.pt
RI Matafome, Paulo/AAQ-4113-2020; de Picoli Souza, Kely/AAU-5978-2020;
   Monteiro Alfredo, Tamaeh/G-5134-2018; de Picoli Souza, Kely/I-1248-2015;
   Macedo, Maria Ligia Rodrigues/AGK-3444-2022
OI de Picoli Souza, Kely/0000-0001-5764-2125; Matafome,
   Paulo/0000-0002-3422-290X; Monteiro Alfredo, Tamaeh/0000-0001-5514-0797;
   Macedo, Maria Ligia Rodrigues/0000-0001-6969-6307
FU Portugal Foundation for Science and Technology [UIDB/04539/2020,
   UIDP/04539/2020, LA/P/0058/2020]; Fundacao de Apoio ao Desenvolvimento
   do Ensino, Ciencia e Tecnologia do Estado deMato Grosso do Sul
   (FUNDECT); Coordenacao de Aperfeicoamento de Pessoal de Nivel
   Superior(CAPES); Conselho Nacional de Desenvolvimento Cientifico e
   Tecnologico (CNPq)
FX This work was supported by Portugal Foundation for Science and
   Technology (strategicprojects UIDB/04539/2020, UIDP/04539/2020, and
   LA/P/0058/2020: CIBB). This work was also supported by Fundacao de Apoio
   ao Desenvolvimento do Ensino, Ciencia e Tecnologia do Estado deMato
   Grosso do Sul (FUNDECT), Coordenacao de Aperfeicoamento de Pessoal de
   Nivel Superior(CAPES), and Conselho Nacional de Desenvolvimento
   Cientifico e Tecnologico (CNPq).
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NR 187
TC 1
Z9 1
U1 3
U2 13
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD NOV
PY 2023
VL 24
IS 21
AR 15588
DI 10.3390/ijms242115588
PG 25
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA X7MI9
UT WOS:001100243700001
PM 37958572
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Mandour, DA
   Morsy, MM
   Fawzy, A
   Mohamed, NM
   Ahmad, MM
AF Mandour, Dalia A.
   Morsy, Manal M.
   Fawzy, Amal
   Mohamed, Noura Mostafa
   Ahmad, Marwa M.
TI Structural and molecular changes in the rat myocardium following
   perfluoroctane sulfonate (PFOS) exposure are mitigated by quercetin via
   modulating HSP 70 and SERCA 2
SO JOURNAL OF MOLECULAR HISTOLOGY
LA English
DT Article
DE PFOS; Myocardium; Immunohistochemistry; Gene expression; Quercetin; Rats
ID LOW-DENSITY-LIPOPROTEIN; PERFLUOROOCTANE SULFONATE; POLYFLUOROALKYL
   SUBSTANCES; PERFLUORINATED COMPOUNDS; METABOLIC SYNDROME; OXIDATIVE
   STRESS; WATER SAMPLES; IN-VITRO; PERFLUOROALKYL; PERFLUOROCHEMICALS
AB Perfluorooctane sulfonate (PFOS) is a man-made fluorinated compound employed in a variety of industrial and civilian applications. Due to its long elimination half-life and promotion of oxidative stress and inflammation, it is one of the most abundant organic contaminants. The present study was designed to determine the cytotoxic effect of PFOS on adult male rat cardiac tissue and to assess the cardioprotective role of the flavonoid quercetin (Que), which possesses antioxidant, anti-inflammatory, and anti-apoptotic properties. Twenty-four adult male Sprague-Dawley rats were randomly divided into four equal groups: Group I (Control). Group II (Que) received Que (75 mg/kg/day for 4 weeks) by oral gavage. Group III (PFOS group): supplemented orally with PFOS (20 mg/kg/day for 4 weeks) and Group IV (PF OS/Que). The rat heart was processed for histological, immunohistochemical, and gene expression studies. The PFOS group showed histological alterations in the myocardium that were partially reversed by the administration of Que. The inflammatory biomarkers (TNF, IL-6, and IL-1), lipid profile, TSH, MDA, and serum cardiac enzymes (LDH and CK-MB) were all altered. These findings collectively suggest that PFOS had adverse effects on the cardiac muscle structure, and these effects were alleviated by quercetin, which is a promising cardioprotective flavonoid.
C1 [Mandour, Dalia A.; Morsy, Manal M.; Ahmad, Marwa M.] Zagazig Univ, Fac Med, Dept Human Anat & Embryol, Zagazig, Egypt.
   [Fawzy, Amal; Mohamed, Noura Mostafa] Zagazig Univ, Fac Med, Dept Biochem, Zagazig, Egypt.
C3 Egyptian Knowledge Bank (EKB); Zagazig University; Egyptian Knowledge
   Bank (EKB); Zagazig University
RP Ahmad, MM (corresponding author), Zagazig Univ, Fac Med, Dept Human Anat & Embryol, Zagazig, Egypt.
EM daabdelhamid@medicine.zu.edu.eg; MMOmmar@medicine.zu.edu.eg;
   AFHassan@medicine.zu.edu.eg; NMMohamed@pnu.edu.sa;
   mmabdelkarim@zu.edu.eg
RI Mostafa, Noura/HSH-0220-2023; Mandour, Dalia/HHC-7923-2022; Ahmed,
   Marwa/KGK-5581-2024
OI Mohamed, Noura/0000-0002-0270-0305
FU Science, Technology amp; Innovation Funding Authority (STDF)
FX Open access funding provided by The Science, Technology & Innovation
   Funding Authority (STDF) in cooperation with The Egyptian Knowledge Bank
   (EKB). This research did not receive any specific grant from funding
   agencies in the public, commercial, or not-for-profit sectors.
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NR 69
TC 4
Z9 4
U1 3
U2 10
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1567-2379
EI 1567-2387
J9 J MOL HISTOL
JI J. Mol. Histol.
PD AUG
PY 2023
VL 54
IS 4
BP 283
EP 296
DI 10.1007/s10735-023-10134-9
EA JUN 2023
PG 14
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA O4GQ7
UT WOS:001016472900001
PM 37365388
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Bae, SJ
   Lee, WY
   Bak, SB
   Kim, YE
   Kim, MJ
   Kim, YW
AF Bae, Su-Jin
   Lee, Won-Yung
   Bak, Seon-Been
   Kim, Young-Eun
   Kim, Min-Jin
   Kim, Young-Woo
TI Unraveling the Antioxidant Capacity of Spatholobi caulis in
   Nonalcoholic Fatty Liver Disease: A Multiscale Network Approach
   Integrated with Experimental Validation
SO ANTIOXIDANTS
LA English
DT Article
DE oxidative stress; non-alcoholic fatty liver diseases; Spatholobi caulis;
   multiscale network
ID PROCYANIDIN B2 PROTECTS; NADPH OXIDASES; YAP; PHARMACOLOGY; MODULATION;
   MECHANISMS; APOPTOSIS; INJURY; AMPK
AB Nonalcoholic fatty liver disease (NAFLD) is a global health problem that is closely associated with obesity and metabolic syndrome. Spatholobi caulis (SC) is a herbal medicine with potential hepatoprotective effects; however, its active compounds and underlying mechanisms have not been fully explored. In this study, we combined a multiscale network-level approach with experimental validation to investigate SC's antioxidant properties and their impact on NAFLD. Data collection and network construction were performed, and active compounds and key mechanisms were identified through multi-scale network analysis. Validation was conducted using in vitro steatotic hepatocyte models and in vivo high-fat diet-induced NAFLD models. Our findings revealed that SC treatment improved NAFLD by modulating multiple proteins and signaling pathways, including AMPK signaling pathways. Subsequent experiments showed that SC treatment reduced lipid accumulation and oxidative stress. We also validated SC's effects on AMPK and its crosstalk pathways, emphasizing their role in hepatoprotection. We predicted procyanidin B2 to be an active compound of SC and validated it using a lipogenesis in vitro model. Histological and biochemical analyses confirmed that SC ameliorated liver steatosis and inflammation in mice. This study presents SC's potential use in NAFLD treatment and introduces a novel approach for identifying and validating active compounds in herbal medicine.
C1 [Bae, Su-Jin; Lee, Won-Yung; Bak, Seon-Been; Kim, Young-Eun; Kim, Min-Jin; Kim, Young-Woo] Dongguk Univ, Sch Korean Med, Gyeonju 38066, South Korea.
   [Kim, Young-Woo] Kyungpook Natl Univ, Dept Comp Sci & Engn, Daegu 41566, South Korea.
C3 Dongguk University; Kyungpook National University (KNU)
RP Kim, YW (corresponding author), Dongguk Univ, Sch Korean Med, Gyeonju 38066, South Korea.; Kim, YW (corresponding author), Kyungpook Natl Univ, Dept Comp Sci & Engn, Daegu 41566, South Korea.
EM realsujin@dgu.ac.kr; wonyung21@dongguk.ac.kr; sbpark@dongguk.ac.kr;
   yekim@dgu.ac.kr; mjkim@dgu.ac.kr; ywk@dongguk.ac.kr
RI Kim, Tackeun/N-8436-2019
OI Kim, Young Woo/0000-0002-3323-7106; Bae, Su-jin/0000-0001-8884-7940
FU Korea Health Technology R&D Project through the Korea Health Industry
   Development Institute (KHIDI); Ministry of Health & Welfare, Republic of
   Korea [HF20C0212, HF21C0061]
FX This research was also supported by a grant of the Korea Health
   Technology R&D Project through the Korea Health Industry Development
   Institute (KHIDI), and was funded by the Ministry of Health & Welfare,
   Republic of Korea (grant numbers: HF20C0212 and HF21C0061).
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NR 54
TC 3
Z9 3
U1 2
U2 12
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD MAY 13
PY 2023
VL 12
IS 5
AR 1097
DI 10.3390/antiox12051097
PG 18
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA H3IC3
UT WOS:000994925800001
PM 37237962
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Heidary, Z
   Khalili, H
   Mohammadi, M
   Beigmohammadi, MT
   Abdollahi, A
AF Heidary, Zinat
   Khalili, Hossein
   Mohammadi, Mostafa
   Beigmohammadi, Mohammad-Taghi
   Abdollahi, Alireza
TI Effect of Magnesium Loading Dose on Insulin Resistance in Patients With
   Stress-Induced Hyperglycemia: A Randomized Clinical Trial
SO JOURNAL OF INTENSIVE CARE MEDICINE
LA English
DT Article
DE hyperglycemia; insulin resistance; magnesium
ID CRITICALLY-ILL PATIENTS; INTENSIVE-CARE-UNIT; HOSPITAL MORTALITY;
   METABOLIC SYNDROME; DOUBLE-BLIND; HYPOMAGNESEMIA; INFLAMMATION;
   MANAGEMENT
AB Objectives:
   There is currently no evidence that whether magnesium supplementation would improve stress-induced hyperglycemia (SIH) in critically ill patients. In this study, effects of magnesium loading dose on insulin resistance (IR) indices were evaluated in critically ill patients without diabetes having SIH.
   Methods:
   Seventy critically ill patients with SIH were assigned to receive a loading dose of magnesium (7.5 g of magnesium sulfate in 500 mL normal saline as intravenous infusion over an 8-hour period) or placebo. Changes in baseline of serum and intracellular magnesium and serum adiponectin (AD) levels, homeostasis model assessment of IR (HOMA-IR), and HOMA-AD ratio were assessed in this study.
   Results:
   Serum and intracellular magnesium levels increased significantly in patients in the magnesium group (P < .001). At day 3, there were significant differences between the magnesium group and the placebo group in the mean changes from baseline in the HOMA (between-group difference: -0.11; 95% confidence interval [CI]: -0.19 to -0.01; P = .02), the AD (between-group difference: 0.94; 95% CI: 0.41-1.48; P = .04), and the HOMA-AD ratio (between-group difference: -0.03; 95% CI: -0.04 to -0.01; P < .001).
   Conclusion:
   In the present study, a single-loading dose of intravenous magnesium improved IR indices in critically ill patients with SIH.
C1 [Heidary, Zinat; Khalili, Hossein] Univ Tehran Med Sci, Fac Pharm, Dept Clin Pharm, Tehran, Iran.
   [Mohammadi, Mostafa; Beigmohammadi, Mohammad-Taghi] Univ Tehran Med Sci, Imam Khomeini Hosp, Fac Med, Dept Intens Care Unit, Tehran, Iran.
   [Abdollahi, Alireza] Univ Tehran Med Sci, Fac Med, Dept Pathol, Tehran, Iran.
C3 Tehran University of Medical Sciences; Tehran University of Medical
   Sciences; Tehran University of Medical Sciences
RP Khalili, H (corresponding author), Univ Tehran Med Sci, Fac Pharm, Dept Clin Pharm, Tehran, Iran.
EM khalilih@sina.tums.ac.ir
RI Heidary, Zinat/AAG-9364-2021; Mohammadi, MohammadReza/A-2863-2019;
   Abdollahi, Mohammad/B-9232-2008; Khalili, Hossein/AAC-9532-2020
OI Heidary, Zinat/0000-0003-4362-7658; Mohammadi,
   Mostafa/0000-0002-7084-0182
FU Office of Vice Chancellor for Research of Tehran University of Medical
   Sciences, Tehran, Iran
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: This study
   was supported by Office of Vice Chancellor for Research of Tehran
   University of Medical Sciences, Tehran, Iran.
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NR 54
TC 11
Z9 11
U1 1
U2 5
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0885-0666
EI 1525-1489
J9 J INTENSIVE CARE MED
JI J. Intensive Care Med.
PD JUL
PY 2020
VL 35
IS 7
BP 687
EP 693
DI 10.1177/0885066618777431
PG 7
WC Critical Care Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA LT6KU
UT WOS:000537178500010
PM 29788815
DA 2025-06-11
ER

PT J
AU Munkong, N
   Lerdvuthisopon, N
   Parklak, W
   Somnuk, S
   Yoysungnoen, B
   Naowaboot, J
   Somparn, N
   Hansakul, P
AF Munkong, Narongsuk
   Lerdvuthisopon, Nusiri
   Parklak, Wason
   Somnuk, Surasawadee
   Yoysungnoen, Bhornprom
   Naowaboot, Jarinyaporn
   Somparn, Nuntiya
   Hansakul, Pintusorn
TI Rice bran water extract prevents cardiac lipid accumulation and
   oxidative damage in rats fed a high-fat diet
SO MAEJO INTERNATIONAL JOURNAL OF SCIENCE AND TECHNOLOGY
LA English
DT Article
DE rice bran; high-fat diet; metabolic syndrome; cardiac lipotoxicity;
   oxidative stress
ID ENDOTHELIAL FUNCTION; ENZYMATIC EXTRACT; PHYTIC ACID; OBESE RATS;
   STRESS; HEART; DYSFUNCTION; AMPK; ABNORMALITIES; LIPOTOXICITY
AB Rice bran water extract (RBE) has been reported to have cardiovascular protective effects including lipid-lowering and antioxidant effects. The present study aims to investigate the effects of RBE and its possible protective mechanisms against lipid accumulation and oxidative damage to the heart of male Sprague-Dawley rats induced by a high-fat diet (HFD). After four weeks of exclusive HFD feeding, elevated triglyceride, total cholesterol and malondialdehyde contents in the cardiac tissue were examined. The HFD group showed elevated serum levels of free fatty acid, triglyceride and total cholesterol. By contrast, these elevations decreased after four weeks of oral RBE treatment (2,205 mg/kg/day). RBE treatment also increased cardiac free radical-scavenging activity. Mechanistically, expression levels of peroxisome proliferator-activated receptor alpha, AMP-activated protein kinase alpha, glucose transporter 4 and heme oxygenase-1 were up-regulated in the heart of the RBE-treated rats. However, down-regulated expression levels of cluster of differentiation 36, sterol regulatory element binding protein-1 and nuclear factor-kappa B p65 were detected in the RBE-treated group as compared with the HFD group. However, cardiomyocyte size and cardiac marker levels were unchanged between the groups. RBE intake may prevent HFD-induced lipid overaccumulation and oxidative damage in the cardiac tissue, resulting in cardioprotective effects.
C1 [Munkong, Narongsuk] Univ Phayao, Sch Med, Div Pathol, Phayao 56000, Thailand.
   [Lerdvuthisopon, Nusiri; Hansakul, Pintusorn] Thammasat Univ, Div Biochem, Fac Med, Pathum Thani 12120, Thailand.
   [Parklak, Wason] Thammasat Univ, Fac Med, Off Grad Studies, Pathum Thani 12120, Thailand.
   [Somnuk, Surasawadee] Kasetsart Univ, Fac Sports Sci, Dept Sports Sci & Hlth, Kamphaeng Saen Campus, Nakhon Pathom 73140, Thailand.
   [Yoysungnoen, Bhornprom] Thammasat Univ, Div Physiol, Fac Med, Pathum Thani 12120, Thailand.
   [Naowaboot, Jarinyaporn; Somparn, Nuntiya] Thammasat Univ, Div Pharmacol, Fac Med, Pathum Thani 12120, Thailand.
C3 University of Phayao; Thammasat University; Thammasat University;
   Kasetsart University; Thammasat University; Thammasat University
RP Munkong, N (corresponding author), Univ Phayao, Sch Med, Div Pathol, Phayao 56000, Thailand.; Hansakul, P (corresponding author), Thammasat Univ, Div Biochem, Fac Med, Pathum Thani 12120, Thailand.
EM jittmunkong@gmail.com; hansakul@yahoo.com
RI Yoysungnoen, Bhornprom/I-9442-2015
OI Parklak, Wason/0000-0001-9418-3642; Yoysungnoen,
   Bhornprom/0000-0001-7023-3561; Munkong, Narongsuk/0000-0002-0097-6746
FU Faculty of Medicine, Thammasat University; Higher Education Research
   Promotion; National Research University Project of Thailand [2-17/2013,
   2014-76, 2011-67]; National Research Council of Thailand [2-17/2013,
   2014-76, 2011-67]
FX This study was supported by grants from the Faculty of Medicine,
   Thammasat University, the Higher Education Research Promotion and
   National Research University Project of Thailand, and the National
   Research Council of Thailand (No. 2-17/2013, 2014-76 and 2011-67
   respectively).
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NR 45
TC 2
Z9 2
U1 0
U2 3
PU MAEJO UNIV
PI CHIANG MAI
PA MIJST ORCHID BLDG, 1ST FL, SAN SAI, CHIANG MAI, 50290, THAILAND
SN 1905-7873
J9 MAEJO INT J SCI TECH
JI Maejo Int. J. Sci. Technol.
PD MAY-AUG
PY 2019
VL 13
IS 2
BP 96
EP 109
PG 14
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA IL1LN
UT WOS:000477061700002
DA 2025-06-11
ER

PT J
AU Lorin, J
   Zeller, M
   Guilland, JC
   Cottin, Y
   Vergely, C
   Rochette, L
AF Lorin, Julie
   Zeller, Marianne
   Guilland, Jean-Claude
   Cottin, Yves
   Vergely, Catherine
   Rochette, Luc
TI Arginine and nitric oxide synthase: Regulatory mechanisms and
   cardiovascular aspects
SO MOLECULAR NUTRITION & FOOD RESEARCH
LA English
DT Review
DE Arginine; Cardiovascular; Nitric oxide synthase; Therapeutic potential
ID PERIVASCULAR ADIPOSE-TISSUE; VASCULAR SUPEROXIDE-PRODUCTION;
   AMINO-ACID-TRANSPORT; ENDOTHELIAL FUNCTION; OXIDATIVE STRESS;
   L-CITRULLINE; ASYMMETRIC DIMETHYLARGININE; PROTEIN INTERACTIONS;
   MYOCARDIAL-ISCHEMIA; INFARCT SIZE
AB L-Arginine (l-Arg) is a conditionally essential amino acid in the human diet. The most common dietary sources of l-Arg are meat, poultry and fish. l-Arg is the precursor for the synthesis of nitric oxide (NO); a key signaling molecule via NO synthase (NOS). Endogenous NOS inhibitors such as asymmetric-dimethyl-l-Arg inhibit NO synthesis in vivo by competing with l-Arg at the active site of NOS. In addition, NOS possesses the ability to be uncoupled to produce superoxide anion instead of NO. Reduced NO bioavailability may play an essential role in cardiovascular pathologies and metabolic diseases. l-Arg deficiency syndromes in humans involve endothelial inflammation and immune dysfunctions. Exogenous administration of l-Arg restores NO bioavailability, but it has not been possible to demonstrate, that l-Arg supplementation improved endothelial function in cardiovascular disease such as heart failure or hypertension. l-Arg supplementation may be a novel therapy for obesity and metabolic syndrome. The utility of l-Arg supplementation in the treatment of l-Arg deficiency syndromes remains to be established. Clinical trials need to continue to determine the optimal concentrations and combinations of l-Arg, with other protective compounds such as tetrahydrobiopterin (BH4), and antioxidants to combat oxidative stress that drives down NO production in humans.
C1 [Lorin, Julie; Zeller, Marianne; Guilland, Jean-Claude; Cottin, Yves; Vergely, Catherine; Rochette, Luc] Univ Bourgogne, Fac Med & Pharm, Inserm UMR866, LPPCM, F-21000 Dijon, France.
   [Cottin, Yves] Univ Bourgogne, Fac Med & Pharm, Serv Cardiol CHU Dijon, F-21000 Dijon, France.
C3 Institut Agro; AgroSup Dijon; Institut National de la Sante et de la
   Recherche Medicale (Inserm); Universite Bourgogne Europe; Universite
   Bourgogne Europe; CHU Dijon Bourgogne
RP Rochette, L (corresponding author), Univ Bourgogne, Fac Med & Pharm, Inserm UMR866, LPPCM, 7 Bd Jeanne dArc, F-21000 Dijon, France.
EM luc.rochette@u-bourgogne.fr
RI COTTIN, YVES/ABA-4622-2020; VERGELY, CATHERINE/L-9534-2015
OI VERGELY, CATHERINE/0000-0003-4009-776X; Rochette,
   Luc/0000-0001-9973-8803
FU French Ministry of Research; Institut National de la Sante et de la
   Recherche Medicale (INSERM); Regional Council of Burgundy
FX The authors wish to thank Martine Goiset for secretarial assistance and
   Philip Bastable for English assistance. This work was supported by
   grants from the French Ministry of Research, from the Institut National
   de la Sante et de la Recherche Medicale (INSERM) and from the Regional
   Council of Burgundy.
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NR 150
TC 87
Z9 94
U1 4
U2 70
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1613-4125
EI 1613-4133
J9 MOL NUTR FOOD RES
JI Mol. Nutr. Food Res.
PD JAN
PY 2014
VL 58
IS 1
BP 101
EP 116
DI 10.1002/mnfr.201300033
PG 16
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA 302GI
UT WOS:000330590100009
PM 23740826
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Kim, KM
   Kim, BT
   Park, SB
   Cho, DY
   Je, SH
   Kim, KN
AF Kim, Kwang-Min
   Kim, Bom-Taeck
   Park, Sat-Byul
   Cho, Doo-Yeoun
   Je, Sang Hyeon
   Kim, Kyu-Nam
TI Serum Total Bilirubin Concentration Is Inversely Correlated with
   Framingham Risk Score in Koreans
SO ARCHIVES OF MEDICAL RESEARCH
LA English
DT Article
DE Total bilirubin; Framingham risk score; Oxidative stress
ID CORONARY-HEART-DISEASE; UGT1A1-ASTERISK-28 ALLELE;
   MYOCARDIAL-INFARCTION; METABOLIC SYNDROME; OXIDATIVE STRESS;
   GILBERT-SYNDROME; PREDICTION; ASSOCIATION; ANTIOXIDANT; LIPOPROTEIN
AB Background and Aims. Compelling evidence suggests that bilirubin, via its antioxidant potential, has anti-atherogenic properties, and that serum bilirubin concentrations within the reference range for the general population may provide some protection against coronary artery disease (CAD). This study examined the association between serum total bilirubin concentration and Framingham risk score (FRS) in the Korean population.
   Methods. This cross-sectional study was performed on 19,792 Koreans. In addition to FRS, data on body mass index, fasting blood glucose, liver enzymes, lipid profile, uric acid, gamma glutamyltransferase, high-sensitive C-reactive protein and total bilirubin were used.
   Results. Negative correlations were established between log-transformed total bilirubin concentration and FRS (females; r = -0.067, p < 0.001, males; r = -0.128, p < 0.001). Analyses relating total bilirubin to FRS >= 10% utilized multiple confounder adjusted logistic regression. Unadjusted odd ratios for FRS >= 10% were 0.325 (95% CI: 0.160-0.659, p = 0.002) and 0.342 (95% CI: 0.281-0.417, p < 0.001) for log-transformed total bilirubin in females and males, respectively. These inverse relationships remained significant after adjustments for multiple confounders in both genders.
   Conclusions. Increased total bilirubin concentrations are associated with the decrease in FRS. Serum total bilirubin may be helpful to decrease the future risk of CAD. (C) 2012 IMSS. Published by Elsevier Inc.
C1 [Kim, Kwang-Min; Kim, Bom-Taeck; Park, Sat-Byul; Cho, Doo-Yeoun; Je, Sang Hyeon; Kim, Kyu-Nam] Ajou Univ, Sch Med, Dept Family Practice & Community Hlth, Suwon 441749, Gyeonggi Do, South Korea.
C3 Ajou University
RP Kim, KN (corresponding author), Ajou Univ, Sch Med, Dept Family Practice & Community Hlth, 164 Worldcup Ro, Suwon 441749, Gyeonggi Do, South Korea.
EM ktwonm@hanmail.net
RI Cho, Doo-Yeoun/E-2372-2019
OI Cho, Doo-Yeoun/0000-0003-2996-1000
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NR 38
TC 21
Z9 22
U1 0
U2 9
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0188-4409
EI 1873-5487
J9 ARCH MED RES
JI Arch. Med. Res.
PD MAY
PY 2012
VL 43
IS 4
BP 288
EP 293
DI 10.1016/j.arcmed.2012.05.003
PG 6
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 990AN
UT WOS:000307603500005
PM 22595233
DA 2025-06-11
ER

PT J
AU Anastácio, LR
   Ferreira, SC
AF Anastacio, Lucilene Rezende
   Ferreira, Samanta Catherine
TI Nutrition, dietary intake, and eating behavior after liver
   transplantation
SO CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE
LA English
DT Review
DE eating behavior; food intake; liver transplantation; nutritional status
ID WEIGHT-GAIN; METABOLIC SYNDROME; BODY-COMPOSITION; ENERGY-EXPENDITURE;
   OBESITY; SARCOPENIA; CIRRHOSIS; DISEASE; COMPLICATIONS; DEPRESSION
AB Purpose of reviewNutritional status of patients after liver transplantation is affected by dietary intake and this, in turn, is affected by eating behavior. The present review will highlight recent studies on these topics after liver transplantation.Recent findingsMalnutrition drops significantly after liver transplantation. Recovery of weight lost during liver disease occurs within 1 year. Liver transplantation recipients gain weight up to the second or third year, often becoming overweight and obese. Muscle mass may not recover completely, and sarcopenia could increase within 1 year after liver transplantation. Some studies, but not all, demonstrated modifications of food intake before and after liver transplantation. A positive energy balance was found in the first year, and a greater energy intake along time after liver transplantation, although some authors mentioned potential underreporting of the true consumption, mainly among people overweight/obese. Dietary survey methods are unable to detect eating behavior, resulting in a lack of data. Weight gain and obesity were related to higher scores for patterns of eating behaviors after liver transplantation. Food deprivation in the pretransplantation period and psychological factors could affect eating behavior and consequently food intake and nutritional status of liver transplantation patients.SummaryUnderstanding eating behavior after liver transplantation could be key knowledge regarding dietary intake and its impact on nutritional modifications occurring after liver transplantation.
C1 [Anastacio, Lucilene Rezende; Ferreira, Samanta Catherine] Univ Fed Minas Gerais, Sch Pharm, Dept Food Sci, Postgrad Program Food Sci, Belo Horizonte, MG, Brazil.
C3 Universidade Federal de Minas Gerais
RP Anastácio, LR (corresponding author), Univ Fed Minas Gerais, Dept Food Sci, Sch Pharm, Presidente Antonio Carlos Ave 6627, BR-31270901 Belo Horizonte, MG, Brazil.
EM lucilene.rezende@gmail.com
RI Ferreira, Samanta/IXD-3783-2023
OI Rezende Anastacio, Lucilene/0000-0002-2269-0722; Ferreira, Samanta
   Catherine/0000-0002-6240-8488
FU Coordination for the Improvement of Higher Education Personnel (CAPES -
   Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior)
FX The authors thank the Coordination for the Improvement of Higher
   Education Personnel (CAPES - Coordenacao de Aperfeicoamento de Pessoal
   de Nivel Superior) for providing the scholarship of Samanta Catherine
   Ferreira.
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NR 47
TC 11
Z9 14
U1 1
U2 19
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1363-1950
EI 1473-6519
J9 CURR OPIN CLIN NUTR
JI Curr. Opin. Clin. Nutr. Metab. Care
PD SEP
PY 2018
VL 21
IS 5
BP 381
EP 387
DI 10.1097/MCO.0000000000000491
PG 7
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA GR0WE
UT WOS:000442244400011
PM 29927763
DA 2025-06-11
ER

PT J
AU Rhee, SJ
   Lee, H
   Ahn, YM
AF Rhee, Sang Jin
   Lee, Hyunju
   Ahn, Yong Min
TI Association between serum uric acid and depressive symptoms stratified
   by low-grade inflammation status
SO SCIENTIFIC REPORTS
LA English
DT Article
ID C-REACTIVE PROTEIN; METABOLIC SYNDROME; POPULATION; HUMANS; LEVEL
AB Despite increasing evidence for an association between circulating uric acid (UA) and depression, the directionality of this association remains unclear and is potentially moderated by low-grade inflammation. Thus, the present study aimed to investigate the cross-sectional association between serum UA concentration and depressive symptoms in Korean individuals with and without low-grade inflammation, as measured using serum high-specific C-reactive protein (hs-CRP) levels. The final study sample comprised 4188 participants, aged 19-79 years, from the Korea National Health and Nutrition Examination Study 2016. Data on serum uric acid (UA) concentrations, serum hs-CRP levels, Patient Health Questionnaire-9 (PHQ-9) scores, and relative covariates were retrieved. Negative binomial regression with adjustment for the complex sample design was used to analyze the associations. After adjusting for covariates, log-transformed serum UA concentrations and total PHQ-9 scores were positively associated (incidence rate ratio [IRR] = 1.34 [95% confidence interval [CI] = 1.09-1.66]) for participants without low-grade inflammation and inversely associated (IRR = 0.64 [95% CI = 0.45-0.92]) for participants with low-grade inflammation. In conclusion, the direction of the association between serum UA and depressive symptoms was the opposite in participants with and without low-grade inflammation. The study has the limitation of potential uncontrolled confounders.
C1 [Rhee, Sang Jin; Lee, Hyunju; Ahn, Yong Min] Seoul Natl Univ Hosp, Dept Neuropsychiat, 28 Yongon Dong, Seoul 03080, South Korea.
   [Lee, Hyunju; Ahn, Yong Min] Seoul Natl Univ, Dept Psychiat, Coll Med, 28 Yongon Dong, Seoul 03080, South Korea.
   [Ahn, Yong Min] Seoul Natl Univ, Inst Human Behav Med, Med Res Ctr, 28Yongon-Dong, Seoul 03080, South Korea.
C3 Seoul National University (SNU); Seoul National University Hospital;
   Seoul National University (SNU); Seoul National University (SNU)
RP Ahn, YM (corresponding author), Seoul Natl Univ Hosp, Dept Neuropsychiat, 28 Yongon Dong, Seoul 03080, South Korea.; Ahn, YM (corresponding author), Seoul Natl Univ, Dept Psychiat, Coll Med, 28 Yongon Dong, Seoul 03080, South Korea.; Ahn, YM (corresponding author), Seoul Natl Univ, Inst Human Behav Med, Med Res Ctr, 28Yongon-Dong, Seoul 03080, South Korea.
EM aym@snu.ac.kr
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NR 47
TC 11
Z9 11
U1 3
U2 9
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD OCT 14
PY 2021
VL 11
IS 1
AR 20405
DI 10.1038/s41598-021-99312-x
PG 7
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA WH1AH
UT WOS:000707419500061
PM 34650110
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Oyane, NM
   Ursin, R
   Pallesen, S
   Holsten, F
   Bjorvatn, B
AF Oyane, Nicolas M.
   Ursin, Reidun
   Pallesen, Stale
   Holsten, Fred
   Bjorvatn, Bjorn
TI Increased Health Risk in Subjects with High Self-Reported Seasonality
SO PLOS ONE
LA English
DT Article
ID PATTERN ASSESSMENT QUESTIONNAIRE; CORONARY HEART-DISEASE;
   AFFECTIVE-DISORDER; CARDIOVASCULAR-DISEASE; DEPRESSIVE SYMPTOMS;
   GENERAL-POPULATION; METABOLIC SYNDROME; SERUM-CHOLESTEROL; WINTER
   DEPRESSION; HORDALAND HEALTH
AB Background: Seasonal variations in mood and behaviour, termed seasonality, are commonly reported in the general population. As a part of a large cross-sectional health survey in Hordaland, Norway, we investigated the relationship between seasonality, objective health measurements and health behaviours.
   Methodology/Principal Findings: A total of 11,545 subjects between 40-44 years old participated, completing the Global Seasonality Score, measuring seasonality. Waist/hip circumference, BMI and blood pressure were measured, and blood samples were analyzed for total cholesterol, HDL cholesterol, triglycerides and glucose. Subjects also completed a questionnaire on miscellaneous health behaviours (exercise, smoking, alcohol consumption). Hierarchical linear regression analyses were used to investigate associations between seasonality and objective health measurements, while binary logistic regression was used for analysing associations between seasonality and health behaviours. Analyses were adjusted for sociodemographic factors, month of questionnaire completion and sleep duration. Seasonality was positively associated with high waist-hip-ratio, BMI, triglyceride levels, and in men high total cholesterol. Seasonality was negatively associated with HDL cholesterol. In women seasonality was negatively associated with prevalence of exercise and positively associated with daily cigarette smoking.
   Conclusions/Significance: High seasonality was associated with objective health risk factors and in women also with health behaviours associated with an increased risk for cardiovascular disease.
C1 [Oyane, Nicolas M.; Bjorvatn, Bjorn] Univ Bergen, Dept Publ Hlth & Primary Hlth Care, Bergen, Norway.
   [Ursin, Reidun] Univ Bergen, Dept Biomed, Bergen, Norway.
   [Pallesen, Stale] Univ Bergen, Dept Psychosocial Sci, Bergen, Norway.
   [Holsten, Fred] Univ Bergen, Dept Psychiat, Bergen, Norway.
   [Oyane, Nicolas M.; Ursin, Reidun; Pallesen, Stale; Holsten, Fred; Bjorvatn, Bjorn] Haukeland Hosp, Norwegian Competence Ctr Sleep Disorders, N-5021 Bergen, Norway.
C3 University of Bergen; University of Bergen; University of Bergen;
   University of Bergen; University of Bergen; Haukeland University
   Hospital
RP Oyane, NM (corresponding author), Univ Bergen, Dept Publ Hlth & Primary Hlth Care, Bergen, Norway.
EM Nicolas.Oyane@isf.uib.no
RI Bjorvatn, Bjørn/JXN-2722-2024
FU University of Bergen
FX This work was supported by the University of Bergen. The funders had no
   role in study design, data collection and analysis, decision to publish,
   or preparation of the manuscript.
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NR 39
TC 14
Z9 16
U1 0
U2 5
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAR 3
PY 2010
VL 5
IS 3
AR e9498
DI 10.1371/journal.pone.0009498
PG 7
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Science & Technology - Other Topics
GA 562OZ
UT WOS:000275063400008
PM 20209129
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Simon-Szabó, L
   Lizák, B
   Sturm, G
   Somogyi, A
   Takács, I
   Németh, Z
AF Simon-Szabo, Laura
   Lizak, Beata
   Sturm, Gabor
   Somogyi, Aniko
   Takacs, Istvan
   Nemeth, Zsuzsanna
TI Molecular Aspects in the Development of Type 2 Diabetes and Possible
   Preventive and Complementary Therapies
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE insulin signaling; T2DM; insulin resistance; glucose intolerance; life
   style; prevention; complementary therapy; conventional therapy
ID ENDOPLASMIC-RETICULUM STRESS; INSULIN-RECEPTOR SUBSTRATE-1; N-TERMINAL
   KINASE; PROTEIN-KINASE; GLUT4 TRANSLOCATION; METABOLIC SYNDROME;
   SKELETAL-MUSCLE; GLUCOSE-UPTAKE; TYROSINE PHOSPHORYLATION; SERINE
   PHOSPHORYLATION
AB The incidence of diabetes, including type 2 diabetes (T2DM), is increasing sharply worldwide. To reverse this, more effective approaches in prevention and treatment are needed. In our review, we sought to summarize normal insulin action and the pathways that primarily influence the development of T2DM. Normal insulin action involves mitogenic and metabolic pathways, as both are important in normal metabolic processes, regeneration, etc. However, through excess energy, both can be hyperactive or attenuated/inactive leading to disturbances in the cellular and systemic regulation with the consequence of cellular stress and systemic inflammation. In this review, we detailed the beneficial molecular changes caused by some important components of nutrition and by exercise, which act in the same molecular targets as the developed drugs, and can revert the damaged pathways. Moreover, these induce entire networks of regulatory mechanisms and proteins to restore unbalanced homeostasis, proving their effectiveness as preventive and complementary therapies. These are the main steps for success in prevention and treatment of developed diseases to rid the body of excess energy, both from stored fats and from overnutrition, while facilitating fat burning with adequate, regular exercise in healthy people, and together with necessary drug treatment as required in patients with insulin resistance and T2DM.
C1 [Simon-Szabo, Laura; Lizak, Beata] Semmelweis Univ, Dept Mol Biol, Tuzolto U 37-47, H-1094 Budapest, Hungary.
   [Sturm, Gabor] Semmelweis Univ, Directorate Informat Technol Basic Infrastruct & A, Ulloi Ut 78-b, H-1082 Budapest, Hungary.
   [Somogyi, Aniko] Semmelweis Univ, Dept Internal Med & Hematol, H-1085 Budapest, Hungary.
   [Takacs, Istvan; Nemeth, Zsuzsanna] Semmelweis Univ, Dept Internal Med & Oncol, Koranyi S U 2-a, H-1083 Budapest, Hungary.
C3 Semmelweis University; Semmelweis University; Semmelweis University;
   Semmelweis University
RP Németh, Z (corresponding author), Semmelweis Univ, Dept Internal Med & Oncol, Koranyi S U 2-a, H-1083 Budapest, Hungary.
EM szabo.laura@semmelweis.hu; lizak.beata@semmelweis.hu;
   sturm.gabor@semmelweis.hu; somogyi.aniko@med.semmelweis-univ.hu;
   takacs.istvan@semmelweis.hu; nemeth.zsuzsanna@semmelweis.hu
RI Takács, István/O-3018-2017; Németh, Zsuzsanna/X-1731-2018
OI Simon-Szabo, Laura/0009-0000-9543-2663
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NR 214
TC 2
Z9 2
U1 2
U2 4
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD AUG
PY 2024
VL 25
IS 16
AR 9113
DI 10.3390/ijms25169113
PG 26
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA E7M7A
UT WOS:001304814500001
PM 39201799
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Wong, BJ
   Turner, CG
   Hayat, MJ
   Otis, JS
   Quyyumi, AA
AF Wong, Brett J.
   Turner, Casey G.
   Hayat, Matthew J.
   Otis, Jeffrey S.
   Quyyumi, Arshed A.
TI Inhibition of superoxide and iNOS augment cutaneous nitric
   oxide-dependent vasodilation in non-Hispanic black young adults
SO PHYSIOLOGICAL REPORTS
LA English
DT Article
DE endothelium; microdialysis; microvascular; oxidative stress
ID SKIN BLOOD-FLOW; THERMAL HYPEREMIA; HYPERPOLARIZING FACTOR; RECEPTOR
   INHIBITION; METABOLIC SYNDROME; AFRICAN-AMERICANS; STRESS; HEALTH;
   BIOAVAILABILITY; CONTRIBUTES
AB We assessed the combined effect of superoxide and iNOS inhibition on microvascular function in non-Hispanic Black and non-Hispanic White participants (n = 15 per group). Participants were instrumented with four microdialysis fibers: (1) lactated Ringer's (control), (2) 10 mu M tempol (superoxide inhibition), (3) 0.1 mM 1400 W (iNOS inhibition), (4) tempol + 1400 W. Cutaneous vasodilation was induced via local heating and NO-dependent vasodilation was quantified. At control sites, NO-dependent vasodilation was lower in non-Hispanic Black (45 +/- 9% NO) relative to non-Hispanic White (79 +/- 9% NO; p < 0.01; effect size, d = 3.78) participants. Tempol (62 +/- 16% NO), 1400 W (78 +/- 12% NO) and tempol +1400 W (80 +/- 13% NO) increased NO-dependent vasodilation in non-Hispanic Black participants relative to control sites (all p < 0.01; d = 1.22, 3.05, 3.03, respectively). The effect of 1400 W (p = 0.04, d = 1.11) and tempol +1400 W (p = 0.03, d = 1.22) was greater than tempol in non-Hispanic Black participants. There was no difference between non-Hispanic Black and non-Hispanic White participants at 1400 W or tempol + 1400 W sites. These data suggest iNOS has a greater effect on NO-dependent vasodilation than superoxide in non-Hispanic Black participants.
C1 [Wong, Brett J.; Turner, Casey G.; Otis, Jeffrey S.] Georgia State Univ, Dept Kinesiol & Hlth, 125 Decatur St SE,Suite 137, Atlanta, GA 30303 USA.
   [Turner, Casey G.] Tufts Med Ctr, Mol Cardiol Res Inst, Boston, MA USA.
   [Hayat, Matthew J.] Georgia State Univ, Sch Publ Hlth, Dept Populat Hlth Sci, Atlanta, GA 30303 USA.
   [Quyyumi, Arshed A.] Emory Univ, Emory Clin Cardiol Res Inst, Sch Med, Atlanta, GA USA.
C3 University System of Georgia; Georgia State University; Tufts Medical
   Center; University System of Georgia; Georgia State University; Emory
   University
RP Wong, BJ (corresponding author), Georgia State Univ, Dept Kinesiol & Hlth, 125 Decatur St SE,Suite 137, Atlanta, GA 30303 USA.
EM bwong@gsu.edu
RI Wong, Brett/I-4243-2019
OI Wong, Brett/0000-0002-4763-0208
FU HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI)
FX We gratefully acknowledge the participants for their time volunteering
   for this study. We also thank James Miller for his assistance with data
   collection.
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NR 45
TC 1
Z9 1
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2051-817X
J9 PHYSIOL REP
JI PHYSIOL. REP.
PD APR
PY 2024
VL 12
IS 8
AR e16021
DI 10.14814/phy2.16021
PG 12
WC Physiology
WE Emerging Sources Citation Index (ESCI)
SC Physiology
GA OE3X0
UT WOS:001205557500001
PM 38639714
OA gold
DA 2025-06-11
ER

PT J
AU Nicholas, SB
AF Nicholas, Susanne B.
TI Novel Anti-inflammatory and Anti-fibrotic Agents for Diabetic Kidney
   Disease-From Bench to Bedside
SO ADVANCES IN CHRONIC KIDNEY DISEASE
LA English
DT Article
DE Metaflammation; Innate immunity; Cytokines; Signaling pathways; Fibrosis
ID MINERALOCORTICOID RECEPTOR ACTIVATION; BASE-LINE CHARACTERISTICS;
   BARDOXOLONE METHYL; OXIDATIVE STRESS; CLINICAL-TRIAL; RENAL-FUNCTION;
   SIGNALING PATHWAY; PROTECTIVE ROLES; URINARY ALBUMIN; ASK1 INHIBITOR
AB Chronic low-grade inflammation, now coined by the new paradigm as "metaflammation" or "metainflammation", has been linked to chronic kidney disease and its progression. In diabetes, altered metabolism denotes factors associated with the metabolic syndrome and hyperglycemia, among others. The interplay among hyperglycemia, oxidative stress, and inflammation in the pathogenesis of diabetic kidney disease (DKD) has been broadly explored. Identification of mediators of inflammatory processes involving macrophage infiltration, production of inflammasomes, release of cytokines, and activation of pertinent signaling pathways including mitogen-activated protein kinase, Jun N-terminal kinase, Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway (JAK/STAT), and apoptosis signal-regulating kinase 1 signaling mechanisms have enabled the development of therapeutic agents for DKD. This review describes the evidence supporting the contribution of the inflammatory response and fibrotic changes and focuses on selected, novel, promising drugs as well as repurposed drugs that have made it to phase 2, 3, or 4 of clinical trials in adults with type 2 diabetes mellitus and their potential to become an important part of our armamentarium to improve the management of DKD. Importantly, drugs that solely target inflammatory processes may be insufficient to fully optimize care of patients with DKD because of the complex nature of the disease.
C1 [Nicholas, Susanne B.] Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90095 USA.
C3 University of California System; University of California Los Angeles;
   University of California Los Angeles Medical Center; David Geffen School
   of Medicine at UCLA
RP Nicholas, SB (corresponding author), Univ Calif Los Angeles, David Geffen Sch Med, Div Nephrol, Div Endocrinol Diabet & MiTholism,Div Gen Interna, 7-155 Factor Bldg,10833 Le Conte Blvd, Los Angeles, CA 90095 USA.
EM sunicholas@mednet.ucla.edu
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NR 124
TC 14
Z9 17
U1 1
U2 2
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 1548-5595
EI 1548-5609
J9 ADV CHRONIC KIDNEY D
JI Adv. Chronic Kidney Dis.
PD JUL
PY 2021
VL 28
IS 4
BP 378
EP 390
DI 10.1053/j.ackd.2021.09.010
EA DEC 2021
PG 13
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA XT3MH
UT WOS:000733495600013
PM 34922694
DA 2025-06-11
ER

PT J
AU Erdal, M
   Altunkaynak, BZ
   Kocaman, A
   Alkan, I
   Oztas, E
AF Erdal, M.
   Altunkaynak, B. Z.
   Kocaman, A.
   Alkan, I
   Oztas, E.
TI The role of HMGB1 in liver inflammation in obese rats
SO BIOTECHNIC & HISTOCHEMISTRY
LA English
DT Article
DE HMGB1; inflammation; kupffer cell; liver; obesity; rats; stereology
ID ENDOPLASMIC-RETICULUM STRESS; LIFE-STYLE INTERVENTION; OXIDATIVE STRESS;
   ADIPOSE-TISSUE; METABOLIC SYNDROME; PATHOGENESIS; EXPRESSION;
   ANGIOGENESIS; PROGRESSION; MECHANISMS
AB Obesity is a chronic disease that is characterized by increased body fat owing to imbalance between consumed and expended energy. Inflammation generally is accompanied by accumulation of excess lipid in adipose tissue and liver. High mobility group box-1 (HMGB1) participates in the pathogenesis of inflammatory diseases. We investigated the relation of the number of HMGB1 positive cells to body mass index (BMI), liver inflammation and the number of Kupffer cells. We divided 18 female Wistar albino rats into two groups: group 1, untreated control fed normal commercial rat diet and group 2, obese rats fed a special diet containing 40% fat. The plasma concentrations of cholesterol, glucose, superoxide dismutase enzyme (SOD) and catalase activities were measured for all animals. The numbers of hepatocytes, Kupffer cells and HMGB1 positive cells were counted using stereological methods. The mean numbers of Kupffer cells and HMGB1 positive cells were higher for group 2 than for group 1. The concentrations of plasma cholesterol and glucose levels also were higher in group 2. Plasma levels of SOD and catalase were significantly lower in group 2 compared to group 1. The number of HMGB1 cells was related directly to BMI and inflammation. The role of HMGB1 was demonstrated for the liver of the obese group. We demonstrated the relations among HMGB1, BMI, obesity and inflammation.
C1 [Erdal, M.; Oztas, E.] Gulhane Mil Med Acad, Dept Histol & Embryol, Ankara, Turkey.
   [Altunkaynak, B. Z.] Istanbul Okan Univ, Med Sch, Dept Histol & Embryol, Istanbul, Turkey.
   [Kocaman, A.; Alkan, I] Ondokuz Mayis Univ, Med Sch, Dept Histol & Embryol, Samsun, Turkey.
C3 Gulhane Military Medical Academy; Okan University; Ondokuz Mayis
   University
RP Kocaman, A (corresponding author), Ondokuz Mayis Univ, Fac Med, Dept Histol & Embryol, Samsun, Turkey.
EM adem.kocaman@omu.edu.tr
RI Kocaman, Adem/ABF-1967-2020
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NR 53
TC 4
Z9 5
U1 0
U2 7
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1052-0295
EI 1473-7760
J9 BIOTECH HISTOCHEM
JI Biotech. Histochem.
PD AUG 18
PY 2019
VL 94
IS 6
BP 449
EP 458
DI 10.1080/10520295.2019.1589573
PG 10
WC Biotechnology & Applied Microbiology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Cell Biology
GA IU5HW
UT WOS:000483618700009
PM 30916587
DA 2025-06-11
ER

PT J
AU Neve, A
   Maruotti, N
   Corrado, A
   Cantatore, FP
AF Neve, Anna
   Maruotti, Nicola
   Corrado, Addolorata
   Cantatore, Francesco Paolo
TI Pathogenesis of ligaments ossification in spondyloarthritis: insights
   and doubts
SO ANNALS OF MEDICINE
LA English
DT Review
DE Spondyloarthritis; enthesis; spinal ligament; ossification
ID BONE MORPHOGENETIC PROTEIN-2; NECROSIS-FACTOR-ALPHA; POSTERIOR
   LONGITUDINAL LIGAMENT; ANTI-INTERLEUKIN-17A MONOCLONAL-ANTIBODY;
   ENDOTHELIAL GROWTH-FACTOR; ANKYLOSING-SPONDYLITIS; DISEASE-ACTIVITY;
   AXIAL SPONDYLOARTHRITIS; METABOLIC SYNDROME; SERUM-LEVELS
AB Despite intensive research in spondyloarthritis pathogenesis, some important questions still remain unanswered, particularly concerning enthesis new bone formation. Several evidences suggest that it prevalently occurs by endochondral ossification, however it remains to identify factors that can induce and influence its initiation and progression. Recent progress, achieved in animal models and in vitro and genetic association studies, has led us to hypothesize that several systemic factors (adipokines and gut hormones) and local factors (BMP and Wnt signaling) as well as angiogenesis and mechanical stress are involved.
   We critically review and summarize the available data and delineate the possible mechanisms involved in enthesis ossification, particularly at spinal ligament level.
   KEY MESSAGES
   Complete understanding of spondyloarthritis pathophysiology requires insights into inflammation, bone destruction and bone formation, which are all located in entheses and lead all together to ankylosis and functional disability.
   Several factors probably play a role in the pathogenesis of bone formation in entheses including not only cytokines but also several systemic factors such as adipokines and gut hormones, and local factors, such as BMP and Wnt signaling, as well as angiogenesis and mechanical stress.
   Data available about pathophysiology of new bone formation in spondyloarthritis are limited and often conflicting and future studies are needed to better delineate it and to develop new therapeutic approaches.
C1 [Neve, Anna; Maruotti, Nicola; Corrado, Addolorata; Cantatore, Francesco Paolo] Univ Foggia, Med Sch, Dept Med & Surg Sci, Rheumatol Clin, Foggia, Italy.
C3 University of Foggia
RP Cantatore, FP (corresponding author), Osped Riuniti Hosp, Rheumatol Clin Mario Carrozzo, Viale Pinto 1, I-71100 Foggia, Italy.
EM francescopaolo.cantatore@unifg.it
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NR 97
TC 10
Z9 11
U1 0
U2 5
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0785-3890
EI 1365-2060
J9 ANN MED
JI Ann. Med.
PY 2017
VL 49
IS 3
BP 196
EP 205
DI 10.1080/07853890.2016.1243802
PG 10
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA ES5SL
UT WOS:000399604000002
PM 27685190
DA 2025-06-11
ER

PT J
AU Galanti, G
   Stefani, L
   Mascherini, G
   Petri, C
   Corsani, I
   Francini, L
   Cattozzo, A
   Gianassi, M
   Minetti, E
   Pacini, A
   Calà, PG
AF Galanti, Giorgio
   Stefani, Laura
   Mascherini, Gabriele
   Petri, Cristian
   Corsani, Ilaria
   Francini, Lorenzo
   Cattozzo, Andrea
   Gianassi, Marco
   Minetti, Enrico
   Pacini, Alessandro
   Cala, Pier Giuseppe
TI Short-term prospective study of prescribed physical activity in kidney
   transplant recipients
SO INTERNAL AND EMERGENCY MEDICINE
LA English
DT Article
DE Exercise; Kidney; Organ transplantation; Physical activity
ID EXERCISE; VALIDATION; CAPACITY; DISEASE
AB Regular physical exercise plays a role in improving cardiovascular and muscular fitness in many metabolic diseases. This study aims to verify any possible benefits, including the eventual influence on any associated risk factors, in a group of kidney transplant recipients after a short period of personalized training programs with mixed exercises. In January 2013, at the Sports Medicine Center of the University of Florence, Italy, we began studying a group of 20 kidney transplant recipients. After 6 months of exercise, they underwent Cardiopulmonary Test (CPET), ECG, skin fold, bioimpedance analysis and stress test for the lower and upper limbs. EF increased significantly from 63.38 +/- A 4 to 67.30 +/- A 5.9 with p < 0.05; the anaerobic threshold improved from 14.48 +/- A 6.3 to 20.24 +/- A 3.7 (p < 0.05) with good stress tolerance, estimated by CR10 scale; weight decreased significantly (70.06-65.03 kg) as did skin folds at pectoral level (p < 0.002). Upper limb muscular strength increased significantly (p < 0.005). Regular mixed exercise is a proposed program in post-transplant syndrome with the expectation of improving cardiovascular performance and enhancing exercise tolerance. Muscle strength improves with physical fitness with consequent reduction of risk factors linked to visceral fat. Proof of an eventual positive impact on other complex aspects associated with post-transplant metabolic syndrome will require a longer follow-up.
C1 [Galanti, Giorgio; Stefani, Laura; Mascherini, Gabriele; Petri, Cristian; Corsani, Ilaria; Francini, Lorenzo; Cattozzo, Andrea; Gianassi, Marco] Univ Florence, Ctr Sports Med, Clin & Expt Dept, Florence, Italy.
   [Minetti, Enrico] Univ Hosp Careggi, Div Nephrol, Florence, Italy.
   [Pacini, Alessandro] Tuscan Transplant Org, OTT, Florence, Italy.
   [Cala, Pier Giuseppe] Directorate Gen Rights Citizenship & Social Cohes, Florence, Italy.
C3 University of Florence; University of Florence; Azienda Ospedaliero
   Universitaria Careggi
RP Stefani, L (corresponding author), Univ Florence, Ctr Sports Med, Clin & Expt Dept, Florence, Italy.
EM laura.stefani@unifi.it
RI Petri, Cristian/HPF-8923-2023; Mascherini, Gabriele/E-5773-2016
OI GALANTI, Giorgio/0000-0002-2054-8650; Mascherini,
   Gabriele/0000-0002-8842-0354; Petri, Cristian/0000-0002-9741-0481
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NR 22
TC 11
Z9 12
U1 0
U2 13
PU SPRINGER-VERLAG ITALIA SRL
PI MILAN
PA VIA DECEMBRIO, 28, MILAN, 20137, ITALY
SN 1828-0447
EI 1970-9366
J9 INTERN EMERG MED
JI Intern. Emerg. Med.
PD FEB
PY 2016
VL 11
IS 1
BP 61
EP 67
DI 10.1007/s11739-015-1294-5
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA DD9JZ
UT WOS:000370242800009
PM 26341217
DA 2025-06-11
ER

PT J
AU Kuwabara, A
   Uenishi, K
   Tanaka, K
AF Kuwabara, Akiko
   Uenishi, Kazuhiro
   Tanaka, Kiyoshi
TI Vitamin K intake and health, consideration from the epidemiological
   studies
SO JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION
LA English
DT Review
DE vitamin K intake; Dietary Reference Intakes; noncommunicable diseases;
   all-cause mortality
ID BONE-MINERAL DENSITY; MATRIX GLA PROTEIN; DEPENDENT PROTEINS;
   DIETARY-INTAKE; HIP-FRACTURES; OLDER-ADULTS; BODY-FAT; RISK;
   ASSOCIATION; JAPANESE
AB The most fundamental function of vitamin K is to activate the blood coagulation factors in the liver. Despite the recent recognition of its extra-hepatic actions, the current Dietary Reference Intakes for vitamin K is based on the amount necessary for maintaining the normal blood coagulation in many countries. To define the Dietary Reference Intake for vitamin K, appropriate biomarkers well-reflecting the vitamin K status are essential. Unfortunately, however, no markers are currently available with properties enabling us to properly define the vitamin K status; i.g., no interference by other factors and the presence of widely approved cut-off values. Thus, Adequate Intake is determined, which is an index based on the representative dietary intake data from healthy individuals. Recently, epidemiological studies have been reported regarding the relationship between vitamin K and noncommunicable diseases including osteoporotic fracture. Furthermore, studies focusing on the relationship between vitamin K intake and metabolic syndrome, physical function, depression, cognition, and all-cause mortality have become available, although limited in number. This review summarizes the recent findings in favor of the novel functions of vitamin K. More epidemiological studies are needed to define the appropriate vitamin K intake value based on the prevention of various disorders.
C1 [Kuwabara, Akiko] Osaka Prefecture Univ, Grad Sch Comprehens Rehabil, Dept Clin Nutr, 3-7-30 Habikino, Habikino, Osaka 5838555, Japan.
   [Uenishi, Kazuhiro] Kagawa Nutr Univ, Div Nutr Physiol, 3-9-21 Chiyoda, Saitama, Saitama 3500288, Japan.
   [Tanaka, Kiyoshi] Kobe Gakuin Univ, Fac Nutr, Nishi Ku, 518 Ikawadanicho Arise, Kobe, Hyogo 6512180, Japan.
C3 Osaka Metropolitan University; Kagawa Nutrition University; Kobe Gakuin
   University
RP Kuwabara, A (corresponding author), Osaka Prefecture Univ, Grad Sch Comprehens Rehabil, Dept Clin Nutr, 3-7-30 Habikino, Habikino, Osaka 5838555, Japan.
EM akuwabara@rehab.osakafu-u.ac.jp
FU JSPS KAKENHI [19K11747, 19K11755]; Grants-in-Aid for Scientific Research
   [19K11755, 19K11747] Funding Source: KAKEN
FX This study was supported in part by the JSPS KAKENHI Grant number
   19K11747 and 19K11755.
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NR 59
TC 4
Z9 6
U1 1
U2 12
PU JOURNAL CLINICAL BIOCHEMISTRY & NUTRITION
PI KYOTO
PA KYOTO PREFECTURAL UNIV MED, GRAD SCH MEDICAL SCIENCE, DEPT MOLECULAR
   GASTROENTEROLOGY & HEPATOLOGY, KYOTO, 602-8566, JAPAN
SN 0912-0009
EI 1880-5086
J9 J CLIN BIOCHEM NUTR
JI J. Clin. Biochem. Nutr.
PD SEP
PY 2021
VL 69
IS 2
BP 111
EP 121
DI 10.3164/jcbn.20-64
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA UK6UG
UT WOS:000692102100001
PM 34616102
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Sandrini, L
   Di Minno, A
   Amadio, P
   Ieraci, A
   Tremoli, E
   Barbieri, SS
AF Sandrini, Leonardo
   Di Minno, Alessandro
   Amadio, Patrizia
   Ieraci, Alessandro
   Tremoli, Elena
   Barbieri, Silvia S.
TI Association between Obesity and Circulating Brain-Derived Neurotrophic
   Factor (BDNF) Levels: Systematic Review of Literature and Meta-Analysis
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE BDNF; obesity; meta-analysis
ID ETHNIC-DIFFERENCES; METABOLIC SYNDROME; AEROBIC EXERCISE; HUMAN
   PLATELETS; SERUM-LEVELS; HYPERPHAGIA; CHILDREN; SCHIZOPHRENIA;
   PUBLICATION; DEPRESSION
AB Reduction in brain-derived neurotrophic factor (BDNF) expression in the brain as well as mutations in BDNF gene and/or of its receptor are associated to obesity in both human and animal models. However, the association between circulating levels of BDNF and obesity is still not defined. To answer this question, we performed a meta-analysis carrying out a systematic search in electronic databases. Ten studies (307 obese patients and 236 controls) were included in the analysis. Our data show that obese patients have levels of BDNF similar to those of controls (SMD: 0.01, 95% CI: -0.28, 0.30, p = 0.94). The lack of difference was further confirmed both in studies in which BDNF levels were assessed in serum (MD: -0.93 ng/mL, 95% CI: -3.34, 1.48, p = 0.45) and in plasma (MD: 0.15 ng/mL, 95% CI: -0.09, 0.39, p = 0.23). Data evaluation has shown that some bias might affect BDNF measurements (e.g., subject recruitment, procedures of sampling, handling, and storage), leading to a difficult interpretation of the results. Standardization of the procedures is still needed to reach strong, affordable, and reliable conclusions.
C1 [Sandrini, Leonardo; Ieraci, Alessandro] Univ Milan, Dipartimento Sci Farmacol & Biomol, I-20133 Milan, Italy.
   [Sandrini, Leonardo; Di Minno, Alessandro; Amadio, Patrizia; Tremoli, Elena; Barbieri, Silvia S.] IRCCS, Ctr Cardiol Monzino, I-20138 Milan, Italy.
C3 University of Milan; IRCCS Centro Cardiologico Monzino
RP Barbieri, SS (corresponding author), IRCCS, Ctr Cardiol Monzino, I-20138 Milan, Italy.
EM leonardo.sandrini@unimi.it; alessandro.diminno@ccfm.it;
   patrizia.amadio@ccfm.it; alessandro.ieraci@unimi.it;
   elena.tremoli@ccfm.it; silvia.barbieri@ccfm.it
RI Amadio, Patrizia/K-3937-2018; Di Minno, Alessandro/K-1948-2016; Ieraci,
   Alessandro/AAA-8738-2020; Barbieri, Silvia Stella/K-2130-2018; Sandrini,
   Leonardo/K-3904-2018
OI Barbieri, Silvia Stella/0000-0002-7486-2637; Sandrini,
   Leonardo/0000-0001-9878-8016; Ieraci, Alessandro/0000-0001-6737-7695
FU Italian Ministry of Health [BIO36-2015: 2622789, BIO37-2016: 2613074,
   BIO37-2017: 2631213]; Italian "5 x 1000" tax
FX This research was funded by the Italian Ministry of Health (Ricerca
   Corrente) grants number BIO36-2015: 2622789; BIO37-2016: 2613074;
   BIO37-2017: 2631213. Co-founding provided by the contribution of the
   Italian "5 x 1000" tax (2013 and 2014).
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NR 70
TC 82
Z9 85
U1 0
U2 15
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD AUG
PY 2018
VL 19
IS 8
AR 2281
DI 10.3390/ijms19082281
PG 15
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA GR7LE
UT WOS:000442869800133
PM 30081509
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Bahadoran, Z
   Mirmiran, P
   Kashfi, K
   Ghasemi, A
AF Bahadoran, Zahra
   Mirmiran, Parvin
   Kashfi, Khosrow
   Ghasemi, Asghar
TI Hyperuricemia-induced endothelial insulin resistance: the nitric oxide
   connection
SO PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
LA English
DT Review
DE Endothelial insulin resistance; Hyperuricemia; Nitric oxide; Uric acid
ID SERUM URIC-ACID; XANTHINE OXIDOREDUCTASE; VASCULAR ENDOTHELIUM;
   PROMOTING PRODUCTION; METABOLIC SYNDROME; SIGNALING PATHWAY; OXIDATIVE
   STRESS; CELLS; DYSFUNCTION; INHIBITION
AB Hyperuricemia, defined as elevated serum concentrations of uric acid (UA) above 416 mu mol L-1, is related to the development of cardiometabolic disorders, probably via induction of endothelial dysfunction. Hyperuricemia causes endothelial dysfunction via induction of cell apoptosis, oxidative stress, and inflammation; however, it's interfering with insulin signaling and decreased endothelial nitric oxide (NO) availability, resulting in the development of endothelial insulin resistance, which seems to be a major underlying mechanism for hyperuricemia-induced endothelial dysfunction. Here, we elaborate on how hyperuricemia induces endothelial insulin resistance through the disruption of insulin-stimulated endothelial NO synthesis. High UA concentrations decrease insulin-induced NO synthesis within the endothelial cells by interfering with insulin signaling at either the receptor or post-receptor levels (i.e., proximal and distal steps). At the proximal post-receptor level, UA impairs the function of the insulin receptor substrate (IRS) and phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) in the insulin signaling pathway. At the distal level, high UA concentrations impair endothelial NO synthase (eNOS)-NO system by decreasing eNOS expression and activity as well as by direct inactivation of NO. Clinically, UA-induced endothelial insulin resistance is translated into impaired endothelial function, impaired NO-dependent vasodilation, and the development of systemic insulin resistance. UA-lowering drugs may improve endothelial function in subjects with hyperuricemia.
C1 [Bahadoran, Zahra; Mirmiran, Parvin] Shahid Beheshti Univ Med Sci, Nutr & Endocrine Res Ctr, Res Inst Endocrine Sci, Tehran, Iran.
   [Kashfi, Khosrow] CUNY, Sch Med, Sophie Davis Sch Biomed Educ, Dept Mol Cellular & Biomed Sci, New York, NY 10031 USA.
   [Kashfi, Khosrow] CUNY, Grad Ctr, Grad Program Biol, New York, NY 10016 USA.
   [Ghasemi, Asghar] Shahid Beheshti Univ Med Sci, Endocrine Physiol Res Ctr, Res Inst Endocrine Sci, 24 Parvaneh St,POB 19395-4763, Tehran, Iran.
C3 Shahid Beheshti University Medical Sciences; City University of New York
   (CUNY) System; Sophie Davis School of Biomedical Education; City
   University of New York (CUNY) System; Shahid Beheshti University Medical
   Sciences
RP Ghasemi, A (corresponding author), Shahid Beheshti Univ Med Sci, Endocrine Physiol Res Ctr, Res Inst Endocrine Sci, 24 Parvaneh St,POB 19395-4763, Tehran, Iran.
EM Ghasemi@endocrine.ac.ir
RI Bahadoran, Zahra/V-2003-2019; Mirmiran, Parvin/V-1433-2019; Ghasemi,
   Asghar/O-4145-2017; Kashfi, Khosrow/A-4351-2008
OI Ghasemi, Asghar/0000-0001-6867-2151; Kashfi, Khosrow/0000-0002-4060-7283
FU Shahid Beheshti University of Medical Sciences, Tehran, Iran [25401]
FX This study has been supported by Shahid Beheshti University of Medical
   Sciences (Grant Number 25401), Tehran, Iran.
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NR 119
TC 25
Z9 31
U1 7
U2 36
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0031-6768
EI 1432-2013
J9 PFLUG ARCH EUR J PHY
JI Pflugers Arch.
PD JAN
PY 2022
VL 474
IS 1
SI SI
BP 83
EP 98
DI 10.1007/s00424-021-02606-2
EA JUL 2021
PG 16
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA YD3CM
UT WOS:000677966600001
PM 34313822
DA 2025-06-11
ER

PT J
AU Feldman, F
   Koudoufio, M
   Desjardins, Y
   Spahis, S
   Delvin, E
   Levy, E
AF Feldman, Francis
   Koudoufio, Mireille
   Desjardins, Yves
   Spahis, Schohraya
   Delvin, Edgard
   Levy, Emile
TI Efficacy of Polyphenols in the Management of Dyslipidemia: A Focus on
   Clinical Studies
SO NUTRIENTS
LA English
DT Review
DE polyphenols; dyslipidemia; lipoproteins; nutrition; oxidative stress;
   inflammation; microbiota; metabolic syndrome; type 2 diabetes
ID HIGH-DENSITY-LIPOPROTEINS; CARDIOVASCULAR-DISEASE RISK; PLASMA
   ANTIOXIDANT CAPACITY; ESTER TRANSFER PROTEIN; DIET-INDUCED OBESITY;
   FATTY LIVER-DISEASE; OXIDATIVE STRESS; INSULIN-RESISTANCE; DOUBLE-BLIND;
   INTESTINAL LIPOPROTEIN
AB Polyphenols (PLPs), phytochemicals found in a wide range of plant-based foods, have gained extensive attention in view of their antioxidant, anti-inflammatory, immunomodulatory and several additional beneficial activities. The health-promoting effects noted in animal models of various non-communicable diseases explain the growing interest in these molecules. In particular, in vitro and animal studies reported an attenuation of lipid disorders in response to PLPs. However, despite promising preclinical investigations, the effectiveness of PLPs in human dyslipidemia (DLP) is less clear and necessitates revision of available literature. Therefore, the present review analyzes the role of PLPs in managing clinical DLP, notably by dissecting their potential in ameliorating lipid/lipoprotein metabolism and alleviating hyperlipidemia, both postprandially and in long-term interventions. To this end, PubMed was used for article search. The search terms included polyphenols, lipids, triglycerides, cholesterol, LDL-cholesterol and /or HDL-cholesterol. The critical examination of the trials published to date illustrates certain benefits on blood lipids along with co-morbidities in participant's health status. However, inconsistent results document significant research gaps, potentially owing to study heterogeneity and lack of rigor in establishing PLP bioavailability during supplementation. This underlines the need for further efforts in order to elucidate and support a potential role of PLPs in fighting DLP.
C1 [Feldman, Francis; Koudoufio, Mireille; Spahis, Schohraya; Delvin, Edgard; Levy, Emile] St Justine Univ, Hlth Ctr, Res Ctr, Montreal, PQ H3T 1C5, Canada.
   [Feldman, Francis; Koudoufio, Mireille; Spahis, Schohraya; Levy, Emile] Univ Montreal, Dept Nutr, Montreal, PQ H3T 1A8, Canada.
   [Feldman, Francis; Koudoufio, Mireille; Desjardins, Yves; Spahis, Schohraya; Levy, Emile] Laval Univ, Inst Nutr & Funct Foods, Quebec City, PQ G1V 4L3, Canada.
   [Delvin, Edgard] Univ Montreal, Dept Biochem, Montreal, PQ H3T 1J4, Canada.
C3 Universite de Montreal; Universite de Montreal; Laval University;
   Universite de Montreal
RP Levy, E (corresponding author), St Justine Univ, Hlth Ctr, Res Ctr, Montreal, PQ H3T 1C5, Canada.; Levy, E (corresponding author), Univ Montreal, Dept Nutr, Montreal, PQ H3T 1A8, Canada.; Levy, E (corresponding author), Laval Univ, Inst Nutr & Funct Foods, Quebec City, PQ G1V 4L3, Canada.
EM francis.feldman@umontreal.ca; mireille.koudoufio@umontreal.ca;
   Yves.Desjardins@fsaa.ulaval.ca; schohraya.spahis.hsj@ssss.gouv.qc.ca;
   delvine@sympatico.ca; emile.levy.hsj@ssss.gouv.qc.ca
RI Desjardins, Yves/F-1222-2013
OI Delvin, Edgard/0000-0002-3130-7748; Feldman,
   Francis/0000-0003-2758-9305; Spahis, Schohraya/0000-0003-4130-4994
FU JA deSeve Research Chair in nutrition [401240871]
FX This work was supported by a grant from the JA deSeve Research Chair in
   nutrition (E.L.) and the NSERC-Diana Food Industrial Chair on prebiotic
   effects of polyphenols (401240871) (E.L. & Y.D.).
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NR 209
TC 49
Z9 52
U1 1
U2 21
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD FEB
PY 2021
VL 13
IS 2
AR 672
DI 10.3390/nu13020672
PG 42
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA QO1KK
UT WOS:000622905400001
PM 33669729
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Lo, CS
   Shi, YX
   Chenier, I
   Ghosh, A
   Wu, CH
   Cailhier, JF
   Ethier, J
   Lattouf, JB
   Filep, JG
   Ingelfinger, JR
   Zhang, SL
   Chan, JSD
AF Lo, Chao-Sheng
   Shi, Yixuan
   Chenier, Isabelle
   Ghosh, Anindya
   Wu, Chin-Han
   Cailhier, Jean-Francois
   Ethier, Jean
   Lattouf, Jean-Baptiste
   Filep, Janos G.
   Ingelfinger, Julie R.
   Zhang, Shao-Ling
   Chan, John S. D.
TI Heterogeneous Nuclear Ribonucleoprotein F Stimulates Sirtuin-1 Gene
   Expression and Attenuates Nephropathy Progression in Diabetic Mice
SO DIABETES
LA English
DT Article
ID COGNITIVE IMPAIRMENT TEST; BRAIN INSULIN-RESISTANCE;
   CENTRAL-NERVOUS-SYSTEM; VERBAL FLUENCY; INTRANASAL INSULIN;
   ALZHEIMERS-DISEASE; METABOLIC SYNDROME; INCREASED RISK; DEMENTIA; MEMORY
AB We investigated the mechanism of heterogeneous nuclear ribonucleoprotein F (hnRNP F) renoprotective action in a type 2 diabetes (T2D) mouse model (db/db). Immortalized rat renal proximal tubular cells (IRPTCs) and kidneys from humans with T2D were also studied. The db/db mice developed hyperglycemia, oxidative stress, and nephropathy at age 20 weeks compared with their db/m littermates. These abnormalities, with the exception of hyperglycemia, were attenuated in db/db hnRNP F-transgenic (Tg) mice specifically overexpressing hnRNP F in their RPTCs. Sirtuin-1, Foxo3 alpha, and catalase expression were significantly decreased in RPTCs from db/db mice and normalized in db/db hnRNP F-Tg mice. In vitro, hnRNP F overexpression stimulated Sirtuin-1 and Foxo3 alpha with downregulation of acetylated p53 expression and prevented downregulation of Sirtuin-1 and Foxo3 alpha expression in IRPTCs by high glucose plus palmitate. Transfection of Sirtuin-1 small interfering RNA prevented hnRNP F stimulation of Foxo3 alpha and downregulation of acetylated p53 expression. hnRNP F stimulated Sirtuin-1 transcription via hnRNP F-responsive element in the Sirtuin-1 promoter. Human T2D kidneys exhibited more RPTC apoptosis and lower expression of hnRNP F, SIRTUIN-1, and Foxo3 alpha than nondiabetic kidneys. Our results demonstrate that hnRNP F protects kidneys against oxidative stress and nephropathy via stimulation of Sirtuin-1 expression and signaling in diabetes.
C1 [Lo, Chao-Sheng; Shi, Yixuan; Chenier, Isabelle; Ghosh, Anindya; Wu, Chin-Han; Cailhier, Jean-Francois; Ethier, Jean; Lattouf, Jean-Baptiste; Zhang, Shao-Ling; Chan, John S. D.] Univ Montreal, Ctr Rech, Ctr Hosp Univ Montreal CRCHUM, Montreal, PQ, Canada.
   [Lo, Chao-Sheng; Shi, Yixuan; Chenier, Isabelle; Ghosh, Anindya; Wu, Chin-Han; Cailhier, Jean-Francois; Ethier, Jean; Lattouf, Jean-Baptiste; Zhang, Shao-Ling; Chan, John S. D.] Univ Montreal, Dept Med, Montreal, PQ, Canada.
   [Filep, Janos G.] Univ Montreal, Ctr Rech, Hop Maisonneuve Rosemont, Montreal, PQ, Canada.
   [Filep, Janos G.] Univ Montreal, Dept Pathol & Cell Biol, Montreal, PQ, Canada.
   [Ingelfinger, Julie R.] Harvard Med Sch, Pediat Nephrol Unit, Massachusetts Gen Hosp, Boston, MA USA.
C3 Universite de Montreal; Universite de Montreal; Universite de Montreal;
   Universite de Montreal; Harvard University; Harvard University Medical
   Affiliates; Massachusetts General Hospital; Harvard Medical School
RP Zhang, SL; Chan, JSD (corresponding author), Univ Montreal, Ctr Rech, Ctr Hosp Univ Montreal CRCHUM, Montreal, PQ, Canada.; Zhang, SL; Chan, JSD (corresponding author), Univ Montreal, Dept Med, Montreal, PQ, Canada.
EM shao.ling.zhang@umontreal.ca; shao.ling.zhang@umontreal.ca
RI Kalantar-Zadeh, Kamyar/Q-4734-2018; Ghosh, Anindya/IAR-8274-2023; Lo,
   Chao-Sheng/ABB-4893-2020
OI Lo, Chao-Sheng/0000-0003-0645-7987; Ghosh, Anindya/0000-0002-8432-5288
FU Montreal Diabetes Research Centre of the CRCHUM; Canadian Institutes of
   Health Research [MOP-97742, MOP-86450, MOP-93650, MOP-106688,
   MOP-84363]; U.S. National Institutes of Health [HL-48455]; Kidney
   Foundation of Canada [KFOC120008]; Canadian Diabetes Association
   [NOD_OG-3-14-4472-JC]
FX C.-S.L. was the recipient of a fellowship from the Montreal Diabetes
   Research Centre of the CRCHUM. This work was supported, in part, by
   grants from the Canadian Institutes of Health Research (MOP-97742 to
   J.G.F., MOP-86450 to S.-L.Z., and MOP-93650, MOP-106688 and MOP-84363 to
   J.S.D.C.), the U.S. National Institutes of Health (HL-48455 to J.R.I.),
   the Kidney Foundation of Canada (KFOC120008 to J.S.D.C.), and the
   Canadian Diabetes Association (NOD_OG-3-14-4472-JC to J.S.D.C.).
   Editorial assistance was provided by the CRCHUM Research Support Office
   and Ovid M. Da Silva (irtc.inc@hotmail.com).
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NR 46
TC 33
Z9 36
U1 0
U2 10
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0012-1797
EI 1939-327X
J9 DIABETES
JI Diabetes
PD JUL 1
PY 2017
VL 66
IS 7
BP 1964
EP 1978
DI 10.2337/db16-1588
PG 15
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA EY2DM
UT WOS:000403778600025
PM 28424160
OA Green Published
DA 2025-06-11
ER

PT J
AU Kong, X
   Wang, GD
   Ma, MZ
   Deng, RY
   Guo, LQ
   Zhang, JX
   Yang, JR
   Su, Q
AF Kong, Xiang
   Wang, Guo-Dong
   Ma, Ming-Zhe
   Deng, Ru-Yuan
   Guo, Li-Qun
   Zhang, Jun-Xiu
   Yang, Jie-Ren
   Su, Qing
TI Sesamin Ameliorates Advanced Glycation End Products-Induced Pancreatic
   β-Cell Dysfunction and Apoptosis
SO NUTRIENTS
LA English
DT Article
DE sesamin; advanced glycation end products; MIN6 cell; reactive oxygen
   species; apoptosis
ID N-ACETYL-CYSTEINE; OXIDATIVE STRESS; METABOLIC SYNDROME;
   ALPHA-TOCOPHEROL; METHYLGLYOXAL; ENDPRODUCTS; INHIBITION; EXPRESSION;
   ISLETS; DAMAGE
AB Advanced glycation end products (AGEs), the direct modulators of -cells, have been shown to cause insulin-producing -cell dysfunction and apoptosis through increase of intracellular reactive oxygen species (ROS) production. Sesamin has been demonstrated to possess antioxidative activity. This study was designed to investigate whether sesamin protects against AGEs-evoked -cell damage via its antioxidant property. The effects of sesamin were examined in C57BL/6J mice and MIN6 cell line. In in vivo studies, mice were intraperitoneally injected with AGEs (120 mg/kg) and orally treated with sesamin (160 mg/kg) for four weeks. Intraperitoneal glucose tolerance and insulin releasing tests were performed. Insulin content, ROS generation and -cell apoptosis in pancreatic islets were also measured. In in vitro studies, MIN6 cells were pretreated with sesamin (50 or 100 M) and then exposed to AGEs (200 mg/L) for 24 h. Insulin secretion, -cell death, ROS production as well as expression and activity of NADPH oxidase were determined. Sesamin treatment obviously ameliorated AGE-induced -cell dysfunction and apoptosis both in vivo and in vitro. These effects were associated with decreased ROS production, down-regulated expression of p67(phox) and p22(phox), and reduced NADPH oxidase activity. These results suggest that sesamin protects -cells from damage caused by AGEs through suppressing NADPH oxidase-mediated oxidative stress.
C1 [Kong, Xiang; Deng, Ru-Yuan; Su, Qing] Shanghai Jiao Tong Univ, Sch Med, Xinhua Hosp, Dept Endocrinol, Shanghai 200092, Peoples R China.
   [Kong, Xiang; Guo, Li-Qun; Zhang, Jun-Xiu; Yang, Jie-Ren] Wannan Med Coll, Dept Pharmacol, Wuhu 241002, Peoples R China.
   [Wang, Guo-Dong] Wannan Med Coll, Dept Pharm, Wuhu 241002, Peoples R China.
   [Ma, Ming-Zhe] Shanghai Jiao Tong Univ, Sch Med, Dept Gen Surg, Xinhua Hosp, Shanghai 200092, Peoples R China.
C3 Shanghai Jiao Tong University; Wannan Medical College; Wannan Medical
   College; Shanghai Jiao Tong University
RP Yang, JR (corresponding author), Wannan Med Coll, Dept Pharmacol, Wuhu 241002, Peoples R China.
EM wnmcyaolikx@sina.com; guodong201@163.com; mmz666@163.com;
   luckyruyuan@163.com; wy_glq@163.com; junxiuzhang@qq.com;
   wnmcyaoli@sina.com; suqingxinhua@163.com
RI Wang, Guodong/GWC-3701-2022; ma, mingzhe/GLR-0560-2022; Kong,
   Xiang/MTG-6398-2025
OI Wang, Guodong/0000-0003-0398-6373
FU Shanghai Jiao Tong University School of Medicine [BXJ201326]; Anhui
   Provincial Natural Science Foundation [1308085QH145, 1508085MH191]; Key
   Program for Excellent Young Talents Foundation of the Education
   Department of Anhui Province [2013SQRL054ZD]; National Natural Science
   Foundation of China [81370935]; Shanghai Municipal Education Commission
   [14ZZ110]; Shanghai Science and Technology Commission [10411956600]
FX This work was supported by grants from the Doctoral Innovation Fund
   Projects from Shanghai Jiao Tong University School of Medicine
   (BXJ201326) and the Anhui Provincial Natural Science Foundation
   (1308085QH145) to Xiang Kong, the Anhui Provincial Natural Science
   Foundation (1508085MH191) and the Key Program for Excellent Young
   Talents Foundation of the Education Department of Anhui Province
   (2013SQRL054ZD) to Guo-Dong Wang, and the National Natural Science
   Foundation of China (81370935), the Innovation Program of Shanghai
   Municipal Education Commission (14ZZ110) and the Key Project of Shanghai
   Science and Technology Commission (10411956600) to Qing Su.
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   Zhao ZS, 2009, ENDOCRINOLOGY, V150, P2569, DOI 10.1210/en.2008-1342
NR 38
TC 43
Z9 50
U1 0
U2 26
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JUN
PY 2015
VL 7
IS 6
BP 4689
EP 4704
DI 10.3390/nu7064689
PG 16
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA CL9FN
UT WOS:000357281800042
PM 26066015
OA Green Submitted, gold, Green Published
DA 2025-06-11
ER

PT J
AU Feng, B
   Xu, L
   Wang, H
   Yan, XF
   Xue, JL
   Liu, FJ
   Hu, JF
AF Feng, Bo
   Xu, Lei
   Wang, Hua
   Yan, Xinfeng
   Xue, Junli
   Liu, Fengjing
   Hu, Ji-Fan
TI Atorvastatin exerts its anti-atherosclerotic effects by targeting the
   receptor for advanced glycation end products
SO BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
LA English
DT Article
DE Atorvastatin; Receptor for advanced glycation end products; RAGE; AGE;
   Diabetes; Atherosclerosis
ID MONOCYTE CHEMOATTRACTANT PROTEIN-1; DEPENDENT PLAQUE STABILIZATION; COA
   REDUCTASE INHIBITORS; PLACEBO-CONTROLLED TRIAL; ACUTE CORONARY
   SYNDROMES; KAPPA-B ACTIVATION; C-REACTIVE PROTEIN; ALPHA-LIPOIC ACID;
   ENDOTHELIAL-CELLS; ACCELERATED ATHEROSCLEROSIS
AB Recent studies demonstrated the beneficial role of atorvastatin in reducing the risk of cardiovascular morbidity and mortality in patients with diabetes mellitus and/or metabolic syndrome. To investigate the mechanisms underlying the anti-atheroscleroic action of atorvastatin, we examined the expression of the receptor for advanced glycation end products (RAGE) and its downstream target gene, monocyte chemoattractant protein-1 (MCP-1) using real-time PCR. In in vitro studies, exposure to high glucose or AGE induced oxidative stress and activation of the AGE/RAGE system in human umbilical vein endothelial cells. Treatment of the cells with atorvastatin significantly released the oxidative stress by restoring the levels of glutathione and inhibited the RAGE upregulation. In diabetic Goto Kakisaki (GK) rats fed with a high-fat diet for 12 weeks, RAGE and MCP-1 were upregulated in the aortas, and there was a significant correlation between RAGE and MCP-1 mRNA abundance (r=0.482, P=0.031). Treatment with atorvastatin (20 mg/kg qd) significantly downregulated the expression of RAGE and MCP-1. These data thus demonstrate a novel "pleiotropic" activity of atorvastatin in reducing the risk of cardiovascular diseases by targeting RAGE expression. (C) 2011 Elsevier B.V. All rights reserved.
C1 [Feng, Bo; Xu, Lei; Wang, Hua; Yan, Xinfeng; Xue, Junli; Liu, Fengjing] Tongji Univ, Dept Endocrinol, Affiliated E Hosp, Shanghai 200120, Peoples R China.
   [Liu, Fengjing; Hu, Ji-Fan] Stanford Univ, Sch Med, VA Palo Alto Hlth Care Syst, Palo Alto, CA 94304 USA.
C3 Tongji University; Stanford University; US Department of Veterans
   Affairs; Veterans Health Administration (VHA); VA Palo Alto Health Care
   System
RP Feng, B (corresponding author), Tongji Univ, Dept Endocrinol, East Hosp, 150 Jimo Rd, Shanghai 200120, Peoples R China.
EM fengbo@medmail.com.cn; jifan@stanford.edu
FU Basic Research Program of Shanghai [08JC1419900]; NIH [1R43
   CA103553-01]; Department of Defense [W81XWH-04-1-0597]; California
   Institute of Regenerative Medicine (CIRM) [RT2-01942]
FX We thank Amy Truong for editing the manuscript. This study was supported
   by the Basic Research Program of Shanghai (08JC1419900) to B.F.; NIH
   grant (1R43 CA103553-01), The Department of Defense Grant
   (W81XWH-04-1-0597), and California Institute of Regenerative Medicine
   (CIRM) grant (RT2-01942) to J.F.H.
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NR 69
TC 35
Z9 39
U1 0
U2 5
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0925-4439
EI 0006-3002
J9 BBA-MOL BASIS DIS
JI Biochim. Biophys. Acta-Mol. Basis Dis.
PD SEP
PY 2011
VL 1812
IS 9
BP 1130
EP 1137
DI 10.1016/j.bbadis.2011.05.007
PG 8
WC Biochemistry & Molecular Biology; Biophysics; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Cell Biology
GA 805HP
UT WOS:000293717800008
PM 21651980
OA Green Accepted, Green Submitted, Bronze
DA 2025-06-11
ER

PT J
AU Beydogan, AB
   Coskun, ZM
   Bolkent, S
AF Beydogan, Alisa Bahar
   Coskun, Zeynep Mine
   Bolkent, Sema
TI The protective effects of Δ<SUP>9</SUP>-tetrahydrocannabinol against
   inflammation and oxidative stress in rat liver with fructose-induced
   hyperinsulinemia
SO JOURNAL OF PHARMACY AND PHARMACOLOGY
LA English
DT Article
DE fructose; hyperinsulinemia; inflammation; liver; tetrahydrocannabinol
ID INSULIN-RESISTANCE; METABOLIC SYNDROME; CB2 RECEPTOR; DIET;
   HYPERTENSION; SENSITIVITY; MECHANISMS; EXPRESSION; PARAMETERS; EXTRACT
AB Objectives A large amount of fructose is metabolized in the liver and causes hepatic functional damage. Delta(9)-tetrahydrocannabinol (THC) is known as a therapeutic agent for clinical and experimental applications. The study aims to investigate the effects of THC treatment on inflammation, lipid profiles and oxidative stress in rat liver with hyperinsulinemia. Methods Sprague-Dawley rats were divided into groups: control, fructose (10% fructose in drinking water for 12 weeks), THC (1.5 mg/kg/day for the last 4 weeks, intraperitoneally) and fructose+THC groups. Biochemical parameters were measured spectrophotometrically. ELISA method was used for insulin measurement. Apoptosis and inflammation markers were detected by the streptavidin-biotin peroxidase method. Key findings The consumptions of food and fluid are inversely proportional to fructose and non-fructose groups. Insulin levels were the highest in fructose group. The reduced glutathione-S-transferase level significantly increased in fructose + THC group compared with fructose group. Total cholesterol level in the fructose + THC group was higher than the fructose group. Caspase-3 and NF-kappa beta immunopositive cell numbers increased in fructose + THC rats compared with fructose group. The number of IL-6 immunopositive cell decreased in fructose + THC group compared with fructose group. Conclusions According to the result, long-term and low-dose THC administration may reduce hyperinsulinemia and inflammation in rats to some extent.
C1 [Beydogan, Alisa Bahar; Bolkent, Sema] Istanbul Univ, Fac Cerrahpasa Med, Dept Med Biol, TR-34098 Istanbul, Turkey.
   [Coskun, Zeynep Mine] Istanbul Bilim Univ, Fac Arts & Sci, Dept Mol Biol & Genet, Istanbul, Turkey.
C3 Istanbul University; Istanbul University - Cerrahpasa; Demiroglu Bilim
   University
RP Bolkent, S (corresponding author), Istanbul Univ, Fac Cerrahpasa Med, Dept Med Biol, TR-34098 Istanbul, Turkey.
EM semabolkent@yahoo.com
RI coskun, zeynep/AAV-1778-2021; Bolkent, Sema/C-9539-2019
OI COSKUN YAZICI, Zeynep Mine/0000-0003-4791-6537; Bolkent,
   Sema/0000-0001-8463-5561
FU Scientific Research Projects Coordination Unit of Istanbul University
   [50228]
FX This study was supported by the Scientific Research Projects
   Coordination Unit of Istanbul University. Project no: 50228.
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NR 46
TC 9
Z9 9
U1 0
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-3573
EI 2042-7158
J9 J PHARM PHARMACOL
JI J. Pharm. Pharmacol.
PD MAR
PY 2019
VL 71
IS 3
BP 408
EP 416
DI 10.1111/jphp.13042
PG 9
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA HK2NQ
UT WOS:000457750000012
PM 30427077
DA 2025-06-11
ER

PT J
AU Zhao, L
   Guo, XX
   Wang, O
   Zhang, HJ
   Wang, Y
   Zhou, F
   Liu, J
   Ji, BP
AF Zhao, Liang
   Guo, Xiaoxuan
   Wang, Ou
   Zhang, Hongjuan
   Wang, Yong
   Zhou, Feng
   Liu, Jia
   Ji, Baoping
TI Fructose and glucose combined with free fatty acids induce metabolic
   disorders in HepG2 cell: A new model to study the impacts of
   high-fructose/sucrose and high-fat diets in vitro
SO MOLECULAR NUTRITION & FOOD RESEARCH
LA English
DT Article
DE Cell model; Free fatty acids; Fructose; HepG2; Metabolic disorders
ID SUGAR-SWEETENED BEVERAGES; ACTIVATED PROTEIN-KINASE; INSULIN-RESISTANCE;
   HEPATIC STEATOSIS; INHIBITS ADIPOGENESIS; 3T3-L1 ADIPOCYTES;
   LIPID-METABOLISM; WEIGHT-GAIN; CONSUMPTION; METAANALYSIS
AB ScopeThis work investigated the underlying mechanism of high-fructose/sucrose and high-fat diets, which rapidly induce metabolic syndrome in vivo, via a new cell model.
   Methods and resultsGlucose and/or fructose were used to induce the human hepatoma cell (HepG2) in the presence of palmitic acid, oleic acid, or combined fatty acids (CFA) for 24 h. The alterations in lipid and uric acid production, glucose metabolism, oxidative status, and related genes and proteins were monitored. The cell model that featured metabolic disorders was established by treatment of 10 mM glucose and 15 mM fructose plus 1 mM CFA. Results showed that palmitic acid mainly induced insulin resistance, oxidative stress, and triglyceride (TG) secretion, whereas oleic acid mainly contributed to intracellular TG. Fructose was mainly responsible for uric acid and cholesterol production. In addition, fructose synergistically elevated the intra- and extracellular TG and extracellular malonaldehyde with glucose and CFA. Regulations of genes and proteins associated with carbohydrate metabolism and lipogenesis partially explained the action of fructose in inducing the metabolic disorders in cell.
   ConclusionThe combination of glucose, fructose, and CFA could successfully induce metabolic disorders in HepG2 cells, including dyslipidemia, insulin resistance, hyperuricemia, and oxidative stress.
C1 [Zhao, Liang; Guo, Xiaoxuan; Wang, Ou; Wang, Yong; Zhou, Feng; Ji, Baoping] China Agr Univ, Coll Food Sci & Nutr Engn, Beijing Key Lab Funct Food Plant Resources, Beijing 100094, Peoples R China.
   [Zhang, Hongjuan] Beijing Ribio Biotech Co, Beijing, Peoples R China.
   [Liu, Jia] China Natl Res Inst Food & Fermentat Ind, Beijing, Peoples R China.
C3 China Agricultural University
RP Ji, BP (corresponding author), China Agr Univ, Coll Food Sci & Nutr Engn, Beijing Key Lab Funct Food Plant Resources, Beijing 100094, Peoples R China.
EM jbp@cau.edu.cn
RI Wang, Ou/AAE-1806-2022
OI Zhao, Liang/0000-0003-2542-9279
FU National Natural Science Foundation of China [31171647]; National Key
   Technology R&D Program in the Twelfth Five-Year Guideline of China
   [2011BAD08B03-01]
FX The authors are grateful for the financial support from National Natural
   Science Foundation of China (no. 31171647) and the National Key
   Technology R&D Program in the Twelfth Five-Year Guideline of China
   (project 2011BAD08B03-01).
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NR 47
TC 41
Z9 49
U1 8
U2 96
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1613-4125
EI 1613-4133
J9 MOL NUTR FOOD RES
JI Mol. Nutr. Food Res.
PD APR
PY 2016
VL 60
IS 4
BP 909
EP 921
DI 10.1002/mnfr.201500635
PG 13
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA DJ4BQ
UT WOS:000374150800018
PM 26763130
DA 2025-06-11
ER

PT J
AU Slocum, SL
   Skoko, JJ
   Wakabayashi, N
   Aja, S
   Yamamoto, M
   Kensler, TW
   Chartoumpekis, DV
AF Slocum, Stephen L.
   Skoko, John J.
   Wakabayashi, Nobunao
   Aja, Susan
   Yamamoto, Masayuki
   Kensler, Thomas W.
   Chartoumpekis, Dionysios V.
TI Keap1/Nrf2 pathway activation leads to a repressed hepatic gluconeogenic
   and lipogenic program in mice on a high-fat diet
SO ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
LA English
DT Article
DE Keap1; Nrf2; Ampk; Diabetes; Gluconeogenesis; Lipogenesis
ID METABOLIC SYNDROME; GENE-EXPRESSION; DIABETES-MELLITUS; INDUCED OBESITY;
   INSULIN-RESISTANCE; KEAP1-NRF2 SYSTEM; OXIDATIVE STRESS; CELL-SURVIVAL;
   LIVER-DISEASE; NRF2
AB The Keap1/Nrf2 pathway, known to regulate the expression of a series of cytoprotective and antioxidant genes, has been studied in the context of obesity and type 2 diabetes; diseases that are characterized by chronic oxidative stress. There is increasing evidence, however, that the transcription factor Nrf2 can crosstalk with pathways not directly related to cytoprotection. Our present work focuses on the effect of Nrf2 on hepatic gluconeogenesis and lipogenesis, two metabolic processes which are dysregulated in the obese/diabetic state. To this end, a genetic mouse model of Nrf2 pathway activation was used (Keap1-hypo; both Keap1 alleles are hypomorphic) and was exposed to a 3-month high-fat diet along with the relevant control wild-type mice. The Keap1-hypo mice were partially protected from obesity, had lower fasting glucose and insulin levels and developed less liver steatosis compared to the wild-type. Key gluconeogenic and lipogenic enzymes were repressed in the Keap1-hypo livers with concomitant activated Ampk signaling. Primary Keap1-hypo hepatocyte cultures also show increased Ampk signaling and repressed glucose production. In conclusion, increased Keap1/Nrf2 signaling in the liver is accompanied by repressed gluconeogenesis and lipogenesis that can, at least partially, explain the ameliorated diabetic phenotype in the Keapl-hypo mice. (c) 2015 Elsevier Inc. All rights reserved.
C1 [Slocum, Stephen L.; Kensler, Thomas W.] Johns Hopkins Univ, Dept Biochem & Mol Biol, Bloomberg Sch Publ Hlth, Baltimore, MD USA.
   [Skoko, John J.; Wakabayashi, Nobunao; Kensler, Thomas W.; Chartoumpekis, Dionysios V.] Univ Pittsburgh, Sch Med, Dept Pharmacol & Chem Biol, Pittsburgh, PA USA.
   [Aja, Susan] Johns Hopkins Univ, Sch Med, Ctr Metab & Obes Res, Baltimore, MD USA.
   [Yamamoto, Masayuki] Tohoku Univ, Sch Med, Dept Med Biochem, Sendai, Miyagi 980, Japan.
   [Kensler, Thomas W.] Johns Hopkins Univ, Dept Environm Hlth Sci, Bloomberg Sch Publ Hlth, Baltimore, MD 21205 USA.
   [Slocum, Stephen L.] MIT, Dept Biol Engn, 77 Massachusetts Ave, Cambridge, MA 02139 USA.
C3 Johns Hopkins University; Johns Hopkins Bloomberg School of Public
   Health; Pennsylvania Commonwealth System of Higher Education (PCSHE);
   University of Pittsburgh; Johns Hopkins University; Tohoku University;
   Johns Hopkins University; Johns Hopkins Bloomberg School of Public
   Health; Massachusetts Institute of Technology (MIT)
RP Chartoumpekis, DV (corresponding author), 200 Lothrop St,E1316 Thomas Starzl Biosci Tower, Pittsburgh, PA USA.
EM dic16@pitt.edu
RI Yamamoto, Masayuki/A-4873-2010; Skoko, John/AAL-1885-2021;
   Chartoumpekis, Dionysios/L-8071-2017; Kensler, Thomas/D-8686-2014
OI Chartoumpekis, Dionysios/0000-0002-6139-6067; Kensler,
   Thomas/0000-0002-6676-261X; Skoko, John/0000-0002-1885-6929;
   Wakabayashi, Nobunao/0000-0003-4643-7841
FU National Institutes of Health [CA94076, CA197222]; Marie Curie (7th
   European Community Framework Programme) [PIOF-GA-2012-329442]
FX This work was supported by grants CA94076 and CA197222 from the National
   Institutes of Health to TWK.DVC is supported by Marie Curie
   PIOF-GA-2012-329442 (7th European Community Framework Programme).
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NR 49
TC 82
Z9 88
U1 0
U2 26
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0003-9861
EI 1096-0384
J9 ARCH BIOCHEM BIOPHYS
JI Arch. Biochem. Biophys.
PD FEB 1
PY 2016
VL 591
BP 57
EP 65
DI 10.1016/j.abb.2015.11.040
PG 9
WC Biochemistry & Molecular Biology; Biophysics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics
GA DE1NT
UT WOS:000370394400007
PM 26701603
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Han, CY
   Ki, SH
   Kim, YW
   Noh, K
   Lee, DY
   Kang, B
   Ryu, JH
   Jeon, R
   Kim, EH
   Hwang, SJ
   Kim, SG
AF Han, Chang Yeob
   Ki, Sung Hwan
   Kim, Young Woo
   Noh, Kyoung
   Lee, Da Yeon
   Kang, Bomi
   Ryu, Jae-Ha
   Jeon, Raok
   Kim, Eun Hyun
   Hwang, Se Jin
   Kim, Sang Geon
TI Ajoene, A Stable Garlic By-Product, Inhibits High Fat Diet-Induced
   Hepatic Steatosis and Oxidative Injury Through LKB1-Dependent AMPK
   Activation
SO ANTIOXIDANTS & REDOX SIGNALING
LA English
DT Article
ID LIVER-X-RECEPTOR; PROTEIN-KINASE; INSULIN-RESISTANCE; LIPID-METABOLISM;
   ALPHA; STRESS; EXPRESSION; COMPOUND; GROWTH; PHOSPHORYLATION
AB Hepatic steatosis, a hepatic component of metabolic syndrome, is common and may progress to steatohepatitis and cirrhosis. The liver X receptor-alpha (LXR alpha)-sterol regulatory element binding protein-1c (SREBP-1c) pathway plays a key role in hepatic steatosis. This study investigated the potential of ajoene, a stable garlic by-product, to inhibit high fat diet (HFD)-induced hepatic steatosis and the underlying mechanism. Ajoene treatment attenuated fat accumulation and induction of lipogenic genes in the liver of HFD-fed mice. Blood biochemical analyses and histopathologic examinations showed that ajoene prevented liver injury with the inhibition of oxidative stress, as evidenced by thiobarbituric acid reactive substances formation and nitrotyrosinylation. Moreover, ajoene treatment inhibited LXR alpha agonist (T0901317)-mediated SREBP-1c activation, and transactivation of the lipogenic target genes in hepatocytes. Ajoene was found to activate AMP-activated protein kinase (AMPK) via LKB1, responsible for the inhibition of p70 ribosomal S6 kinase-1 (S6K1). The ability of ajoene to repress T0901317-induced SREBP-1c expression was antagonized by inhibition of AMPK or activation of S6K1, supporting the role of these kinases in the antisteatotic effect. Our results demonstrate that ajoene has an effect of activating AMPK through LKB1 and inhibit S6K1 activity, contributing to the prevention of SREBP-1c-mediated hepatic lipogenesis via the inhibition of LXR alpha activity. Antioxid Redox Signal. 14, 187-202.
C1 [Han, Chang Yeob; Ki, Sung Hwan; Kim, Young Woo; Noh, Kyoung; Kim, Sang Geon] Seoul Natl Univ, Coll Pharm, Seoul 151742, South Korea.
   [Han, Chang Yeob; Ki, Sung Hwan; Kim, Young Woo; Noh, Kyoung; Kim, Sang Geon] Seoul Natl Univ, Pharmaceut Sci Res Inst, Seoul 151742, South Korea.
   [Lee, Da Yeon; Kang, Bomi; Ryu, Jae-Ha; Jeon, Raok] Sookmyung Womens Univ, Coll Pharm, Seoul, South Korea.
   [Kim, Eun Hyun; Hwang, Se Jin] Hanyang Univ, Coll Med, Seoul 133791, South Korea.
C3 Seoul National University (SNU); Seoul National University (SNU);
   Sookmyung Women's University; Hanyang University
RP Kim, SG (corresponding author), Seoul Natl Univ, Coll Pharm, Seoul 151742, South Korea.
EM sgk@snu.ac.kr
RI Kim, Tae/AAG-9722-2020
FU Korea government (MEST), Korea [2010-0001706]
FX This work was supported by the National Research Foundation of Korea
   grant funded by the Korea government (MEST)(No. 2010-0001706), Korea.
   CYH would like to thank the Seoul Science Fellowship program.
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NR 53
TC 45
Z9 50
U1 1
U2 9
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1523-0864
EI 1557-7716
J9 ANTIOXID REDOX SIGN
JI Antioxid. Redox Signal.
PD JAN
PY 2011
VL 14
IS 2
BP 187
EP 202
DI 10.1089/ars.2010.3190
PG 16
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 695RR
UT WOS:000285390800002
PM 20560786
DA 2025-06-11
ER

PT J
AU Leal, DT
   Fontes, GG
   Villa, JKD
   Freitas, RB
   Campos, MG
   Carvalho, CA
   Pizziolo, VR
   Diaz, MAN
AF Leal, Dalila T.
   Fontes, Gleide G.
   Villa, Julia K. D.
   Freitas, Rodrigo B.
   Campos, Mateus G.
   Carvalho, Camilo A.
   Pizziolo, Virginia R.
   Diaz, Marisa A. N.
TI Zingiber officinale formulation reduces hepatic injury and weight
   gain in rats fed an unhealthy diet
SO ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS
LA English
DT Article
DE cafeteria diet; gingerol; nonalcoholic fatty liver disease; oxidative
   stress; shogaol; Zingiber officinale
ID FATTY LIVER-DISEASE; ANTIOXIDANT CAPACITY; LIPID-PEROXIDATION; METABOLIC
   SYNDROME; ETHANOLIC EXTRACT; INDUCED OBESITY; GINGER; 6-GINGEROL;
   INSULIN; ACCUMULATION
AB This study investigated the ability of formulation containing Zingiber officinale (ginger) to reverse health changes promoted by unhealthy diet in Wistar rats. Five compounds from the gingerol family and three from the shogaol family were identified in the chromatographic analyzes of the extract. The animals were fed a combination of unhealthy foods, the cafeteria diet, which promoted increases in body weight, hepatocyte nucleus area, total hepatocyte area and liver fat accumulation, as well as reduced hepatic glutathione S-transferase concentration, compared to the control group, which received commercial chow. The treatment with ginger improved all these results, highlighting the reduction of 10% of body weight and 66% of the total area of lipid droplets deposited, compared to the group that received the cafeteria diet. Ginger treatments also attenuated lipid peroxidation, with a mean reduction of 41% in malondialdehyde levels and a mean increase of 222% in glutathione S-transferase activity in the liver. The cafeteria diet and ginger extract did not promote significant changes in glycemic and lipid profile, liver weight and liver enzymes compared to the control group. We suggest that ginger can have beneficial effects on health complications associated with unhealthy diet, such as excessive adiposity, oxidative stress and hepatic injury.
C1 [Leal, Dalila T.; Villa, Julia K. D.; Campos, Mateus G.; Pizziolo, Virginia R.; Diaz, Marisa A. N.] Univ Fed Vicosa, Dept Bioquim & Biol Mol, Ave PH Rolfs S-N, BR-36570900 Vicosa, MG, Brazil.
   [Fontes, Gleide G.] Univ Fed Juiz de Fora, Fac Farm, Rua Jose Lourenco Kelmer S-N, BR-36036900 Juiz de Fora, MG, Brazil.
   [Freitas, Rodrigo B.; Carvalho, Camilo A.] Univ Fed Vicosa, Dept Med & Enfermagem, Ave PH Rolfs S-N, BR-36570900 Vicosa, MG, Brazil.
C3 Universidade Federal de Vicosa; Universidade Federal de Juiz de Fora;
   Universidade Federal de Vicosa
RP Diaz, MAN (corresponding author), Univ Fed Vicosa, Dept Bioquim & Biol Mol, Ave PH Rolfs S-N, BR-36570900 Vicosa, MG, Brazil.
EM marisanogueira@ufv.br
RI Diaz, Marisa/N-7935-2014; Carvalho, Camilo/ABF-3156-2021
OI Alves Nogueira Diaz, Marisa/0000-0002-3370-4149
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NR 33
TC 10
Z9 10
U1 3
U2 9
PU ACAD BRASILEIRA DE CIENCIAS
PI RIO JANEIRO
PA RUA ANFILOFIO DE CARVALHO, 29, 3 ANDAR, 20030-060 RIO JANEIRO, BRAZIL
SN 0001-3765
EI 1678-2690
J9 AN ACAD BRAS CIENC
JI An. Acad. Bras. Cienc.
PY 2019
VL 91
IS 4
AR e20180975
DI 10.1590/0001-3765201920180975
PG 11
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA JO0YC
UT WOS:000497311600001
PM 31721920
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Flint, OP
   Noor, MA
   Hruz, PW
   Hylemon, PB
   Yarasheski, K
   Kotler, DP
   Parker, RA
   Bellamine, A
AF Flint, Oliver P.
   Noor, Mustafa A.
   Hruz, Paul W.
   Hylemon, Phil B.
   Yarasheski, Kevin
   Kotler, Donald P.
   Parker, Rex A.
   Bellamine, Aouatef
TI The Role of Protease Inhibitors in the Pathogenesis of HIV-Associated
   Lipodystrophy: Cellular Mechanisms and Clinical Implications
SO TOXICOLOGIC PATHOLOGY
LA English
DT Review
DE protease inhibitors; lipodystrophy; dyslipidemia; insulin resistance;
   cardiovascular disease; mechanisms of toxicity; molecular pathology;
   clinical pathology; in vitro toxicology; endocrine system;
   pharmaceutical development/products
ID REVERSE-TRANSCRIPTASE INHIBITORS; ACTIVE ANTIRETROVIRAL THERAPY;
   ACQUIRED-IMMUNODEFICIENCY-SYNDROME; ELEMENT-BINDING PROTEINS; INDUCED
   MITOCHONDRIAL TOXICITY; PERIPHERAL INSULIN-RESISTANCE;
   ENDOPLASMIC-RETICULUM STRESS; HEALTHY NORMAL VOLUNTEERS;
   LOW-DENSITY-LIPOPROTEIN; VIRUS-INFECTED PATIENTS
AB Metabolic complications associated with HIV infection and treatment frequently present as a relative lack of peripheral adipose tissue associated with dyslipidemia and insulin resistance. In this review we explain the connection between abnormalities of intermediary metabolism, observed either in vitro or in vivo, and this group of metabolic effects. We review molecular mechanisms by which the HIV protease inhibitor ( PI) class of drugs may affect the normal stimulatory effect of insulin on glucose and fat storage. We then propose that both chronic inflammation from HIV infection and treatment with some drugs in this class trigger cellular homeostatic stress responses with adverse effects on intermediary metabolism. The physiologic outcome is such that total adipocyte storage capacity is decreased, and the remaining adipocytes resist further fat storage. The excess circulating and dietary lipid metabolites, normally "absorbed" by adipose tissue, are deposited ectopically in lean ( muscle and liver) tissue, where they impair insulin action. This process leads to a pathologic cycle of lipotoxicity and lipoatrophy and a clinical phenotype of body fat distribution with elevated waist-to-hip ratio similar to the metabolic syndrome.
C1 [Flint, Oliver P.; Parker, Rex A.; Bellamine, Aouatef] Bristol Myers Squibb Co, Pharmaceut Res & Dev, Princeton, NJ USA.
   [Noor, Mustafa A.] GlaxoSmithKline, King Of Prussia, PA USA.
   [Hruz, Paul W.] Washington Univ, Sch Med, Dept Pediat, St Louis, MO 63110 USA.
   [Hylemon, Phil B.] Virginia Commonwealth Univ, Dept Microbiol & Immunol, Richmond, VA 23298 USA.
   [Yarasheski, Kevin] Washington Univ, Sch Med, Dept Med, St Louis, MO 63110 USA.
   [Kotler, Donald P.] Columbia Univ, St Lukes Roosevelt Hosp Ctr, Coll Phys & Surg, Dept Med, New York, NY USA.
C3 Bristol-Myers Squibb; GlaxoSmithKline; Glaxosmithkline USA; Washington
   University (WUSTL); Virginia Commonwealth University; Washington
   University (WUSTL); Columbia University; Mount Sinai St. Luke's; Mount
   Sinai West
RP Flint, OP (corresponding author), POB 5400, Princeton, NJ 08543 USA.
EM oliver.flint@bms.com
RI Hruz, Paul/LDE-7189-2024; Yarasheski, Kevin/AAC-7450-2021
OI Hruz, Paul W/0000-0002-1478-3355; Yarasheski, Kevin/0000-0001-5436-2451
FU NCCIH NIH HHS [R21 AT003083] Funding Source: Medline; NIDDK NIH HHS [R56
   DK049393, R01 DK059531, R01 DK049393, R21 DK074345] Funding Source:
   Medline
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NR 124
TC 81
Z9 92
U1 0
U2 3
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0192-6233
EI 1533-1601
J9 TOXICOL PATHOL
JI Toxicol. Pathol.
PD JAN
PY 2009
VL 37
IS 1
BP 65
EP 77
DI 10.1177/0192623308327119
PG 13
WC Pathology; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pathology; Toxicology
GA 463XE
UT WOS:000267466500009
PM 19171928
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Shen, CY
   Lu, CH
   Cheng, CF
   Li, KJ
   Kuo, YM
   Wu, CH
   Liu, CH
   Hsieh, SC
   Tsai, CY
   Yu, CL
AF Shen, Chieh-Yu
   Lu, Cheng-Hsun
   Cheng, Chiao-Feng
   Li, Ko-Jen
   Kuo, Yu-Min
   Wu, Cheng-Han
   Liu, Chin-Hsiu
   Hsieh, Song-Chou
   Tsai, Chang-Youh
   Yu, Chia-Li
TI Advanced Glycation End-Products Acting as Immunomodulators for Chronic
   Inflammation, Inflammaging and Carcinogenesis in Patients with Diabetes
   and Immune-Related Diseases
SO BIOMEDICINES
LA English
DT Review
DE non-enzymatic Maillard reaction; advanced glycation end-products (AGEs);
   toxic AGE; Diabetes mellitus; AGE binding receptor; lifestyle-related
   disease; immune-related disease; inflamm-aging; carcinogenesis
ID ALTERED GENE-EXPRESSION; LOW-DENSITY-LIPOPROTEIN; OXIDATIVE STRESS;
   NONENZYMATIC GLYCATION; REACTIVE OXYGEN; OXIDANT STRESS; VASCULAR
   COMPLICATIONS; DNA NUCLEOSIDES; NADPH OXIDASE; RISK-FACTOR
AB Increased production of advanced glycation end products (AGEs) among reducing sugars (glucose, fructose, galactose, or ribose) and amino acids/proteins via non-enzymatic Maillard reaction can be found in lifestyle-related disease (LSRD), metabolic syndrome (MetS), and obesity and immune-related diseases. Increased serum levels of AGEs may induce aging, diabetic complications, cardiovascular diseases (CVD), neurodegenerative diseases (NDD), cancer, and inflamm-aging (inflammation with immunosenescence). The Maillard reaction can also occur among reducing sugars and lipoproteins or DNAs to alter their structure and induce immunogenicity/genotoxicity for carcinogenesis. AGEs, as danger-associated molecular pattern molecules (DAMPs), operate via binding to receptor for AGE (RAGE) or other scavenger receptors on cell surface to activate PI3K-Akt-, P38-MAPK-, ERK1/2-JNK-, and MyD88-induced NF-kappa B signaling pathways to mediate various pathological effects. Recently, the concept of "inflamm-aging" became more defined, and we have unveiled some interesting findings in relation to it. The purpose of the present review is to dissect the potential molecular basis of inflamm-aging in patients with diabetes and immune-mediated diseases caused by different AGEs.
C1 [Shen, Chieh-Yu; Lu, Cheng-Hsun; Cheng, Chiao-Feng; Li, Ko-Jen; Kuo, Yu-Min; Hsieh, Song-Chou; Yu, Chia-Li] Natl Taiwan Univ, Natl Taiwan Univ Hosp, Coll Med, Dept Internal Med, 7 Chung Shan South Rd, Taipei 10002, Taiwan.
   [Lu, Cheng-Hsun; Cheng, Chiao-Feng] Natl Taiwan Univ, Inst Clin Med, Coll Med, 7 Chung Shan South Rd, Taipei 10002, Taiwan.
   [Wu, Cheng-Han] Natl Taiwan Univ Hosp, Dept Internal Med, Hsinchu Branch, 2,Sect 1,Shengyi Rd, Zhubei City 302058, Hsinchu County, Taiwan.
   [Liu, Chin-Hsiu] Natl Taiwan Univ Hosp, Dept Internal Med, Yunlin Branch, 579,Sect 2,Yunlin Rd, Touliu 640203, Yunlin County, Taiwan.
   [Tsai, Chang-Youh] Fu Jen Catholic Univ, Fu Jen Catholic Univ Hosp, Coll Med, Dept Internal Med, 69 Guizi Rd, New Taipei 24352, Taiwan.
C3 National Taiwan University; National Taiwan University Hospital;
   National Taiwan University; National Taiwan University; National Taiwan
   University Hospital; National Taiwan University; National Taiwan
   University Hospital; Fu Jen Catholic University; Fu Jen Catholic
   University Hospital
RP Yu, CL (corresponding author), Natl Taiwan Univ, Natl Taiwan Univ Hosp, Coll Med, Dept Internal Med, 7 Chung Shan South Rd, Taipei 10002, Taiwan.; Tsai, CY (corresponding author), Fu Jen Catholic Univ, Fu Jen Catholic Univ Hosp, Coll Med, Dept Internal Med, 69 Guizi Rd, New Taipei 24352, Taiwan.
EM chiehyushen@ntu.edu.tw; b89401085@ntu.edu.tw; chiaofengcheng@gmail.com;
   dtmed170@gmail.com; chenghanwu@ntu.edu.tw; 2001windchild@gmail.com;
   cytsai1240@gmail.com; chialiyu@ntu.edu.tw
RI Tsai, Chang-Youh/IZD-5962-2023; Shen, Chiehyu/JVE-1092-2024; Liu,
   Chin-Hsiu/GRE-7887-2022; Chen, Hsing-yu/C-3979-2011; Tsai,
   Chang-Youh/G-1747-2013
OI /0000-0002-4794-9438; Cheng, Chiao-Feng/0000-0002-8618-9945; Tsai,
   Chang-Youh/0000-0002-4154-4018
FU National Taiwan University Hospital [112-M0007, 113-M0018]; Good Liver
   Foundation, Taiwan, R.O.C.
FX This research was funded by National Taiwan University Hospital (grant
   number 112-M0007 and 113-M0018) and Good Liver Foundation, Taiwan,
   R.O.C.
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NR 145
TC 7
Z9 7
U1 2
U2 4
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2227-9059
J9 BIOMEDICINES
JI Biomedicines
PD AUG
PY 2024
VL 12
IS 8
AR 1699
DI 10.3390/biomedicines12081699
PG 23
WC Biochemistry & Molecular Biology; Medicine, Research & Experimental;
   Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Research & Experimental Medicine;
   Pharmacology & Pharmacy
GA E7W2P
UT WOS:001305064000001
PM 39200164
OA gold
DA 2025-06-11
ER

PT J
AU Galal, A
   El-Bakly, WM
   El-Kilany, SS
   Ali, AA
   El-Demerdash, E
AF Galal, Aya
   El-Bakly, Wesam M.
   El-Kilany, Sara S.
   Ali, Azza A.
   El-Demerdash, Ebtehal
TI Fenofibrate ameliorates olanzapine's side effects without altering its
   central effect: emphasis on FGF-21-adiponectin axis
SO BEHAVIOURAL PHARMACOLOGY
LA English
DT Article
DE brain-derived neurotrophic factor; FGF-21; fenofibrate; isolated
   rearing; metabolic disorders; olanzapine; rats
ID INDUCED WEIGHT-GAIN; INSULIN-RESISTANCE; PPAR-ALPHA; METABOLIC SYNDROME;
   SOCIAL-ISOLATION; BODY-WEIGHT; FOOD-INTAKE; RATS; ADIPONECTIN;
   EXPRESSION
AB The present work was designed to investigate whether fenofibrate could ameliorate olanzapine deleterious effect on insulin resistance via its effect on fibroblast growth factor-21 (FGF-21)-adiponectin axis without affecting olanzapine antipsychotic effect in postweaning socially isolated reared female rats. Treatment with olanzapine (6 mg/kg, intraperitoneally) or fenofibrate (100 mg/kg, orally) have been started 5 weeks after isolation, then behavioral tests, hippocampal content of neurotransmitters, and brain-derived neurotrophic factor (BDNF) were assessed. Moreover, insulin resistance, lipid profile, FGF-21, adiponectin, inflammatory, and oxidative stress markers of adipose tissue were assessed. Treatment of isolated-reared animals with olanzapine, or fenofibrate significantly ameliorated the behavioral and biochemical changes induced by postweaning social isolation. Co-treatment showed additive effects in improving hippocampal BDNF level. Besides, fenofibrate reduced the elevation in weight gain, adiposity index, insulin resistance, lipid profile, and FGF-21 level induced by olanzapine treatment. Also, fenofibrate increased adiponectin level which was reduced upon olanzapine treatment. Moreover, fenofibrate improved both adipose tissue oxidative stress and inflammatory markers elevation as a result of olanzapine treatment. Fenofibrate could ameliorate olanzapine-induced insulin resistance without affecting its central effect in isolated reared rats via its action on FGF-21-adiponectin axis.
C1 [Galal, Aya] Ain Shams Univ, Cardiac Surg Hosp, Cairo, Egypt.
   [El-Bakly, Wesam M.] Ain Shams Univ, Fac Med, Dept Pharmacol, Cairo, Egypt.
   [El-Kilany, Sara S.] Ain Shams Univ, Fac Med, Dept Anat, Cairo, Egypt.
   [Ali, Azza A.] Al Azhar Univ, Dept Pharmacol & Toxicol, Fac Pharm, Girls Branch, Cairo, Egypt.
   [El-Demerdash, Ebtehal] Ain Shams Univ, Fac Pharm, Dept Pharmacol & Toxicol, Cairo, Egypt.
C3 Egyptian Knowledge Bank (EKB); Ain Shams University; Egyptian Knowledge
   Bank (EKB); Ain Shams University; Egyptian Knowledge Bank (EKB); Ain
   Shams University; Egyptian Knowledge Bank (EKB); Al Azhar University;
   Egyptian Knowledge Bank (EKB); Ain Shams University
RP El-Demerdash, E (corresponding author), Ain Shams Univ, Fac Pharm, Dept Pharmacol & Toxicol, Cairo, Egypt.
EM ebtehal_dm@pharma.asu.edu.eg
RI Bakly, wesam/Q-1398-2015; Ali, Azza/AAA-5374-2022; El-Demerdash,
   Ebtehal/ABE-6729-2020
OI Ali, Azza/0000-0002-3700-7199
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NR 70
TC 3
Z9 3
U1 0
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0955-8810
EI 1473-5849
J9 BEHAV PHARMACOL
JI Behav. Pharmacol.
PD DEC
PY 2021
VL 32
IS 8
BP 615
EP 629
DI 10.1097/FBP.0000000000000656
PG 15
WC Behavioral Sciences; Neurosciences; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Behavioral Sciences; Neurosciences & Neurology; Pharmacology & Pharmacy
GA WT5XV
UT WOS:000715938100002
PM 34637209
DA 2025-06-11
ER

PT J
AU Petrakis, D
   Margina, D
   Tsarouhas, K
   Tekos, F
   Stan, M
   Nikitovic, D
   Kouretas, D
   Spandidos, DA
   Tsatsakis, A
AF Petrakis, Demetrios
   Margina, Denisa
   Tsarouhas, Konstantinos
   Tekos, Fotios
   Stan, Miriana
   Nikitovic, Dragana
   Kouretas, Demetrios
   Spandidos, Demetrios A.
   Tsatsakis, Aristidis
TI Obesity-a risk factor for increased COVID-19 prevalence, severity and
   lethality
SO MOLECULAR MEDICINE REPORTS
LA English
DT Review
DE COVID-19; obesity; lipotoxicity; inflammation; oxidative stress; immune
   response
ID DIETARY ENERGY DENSITY; CARDIOVASCULAR-DISEASE RISK; QUALITY-OF-LIFE;
   ADIPOSE-TISSUE; OXIDATIVE STRESS; IMMUNE-SYSTEM; INFLAMMATORY
   BIOMARKERS; METABOLIC SYNDROME; IN-VITRO; INFLUENZA
AB Coronaviruses (CoVs), enveloped positive-sense RNA viruses, are a group of viruses that cause infections in the human respiratory tract, which can be characterized clinically from mild to fatal. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the virus responsible. The global spread of COVID-19 can be described as the worst pandemic in humanity in the last century. To date, COVID-19 has infected more than 3,000,000 people worldwide and killed more than 200,000 people. All age groups can be infected from the virus, but more serious symptoms that can possibly result in death are observed in older people and those with underlying medical conditions such as cardiovascular and pulmonary disease. Novel data report more severe symptoms and even a negative prognosis for the obese patients. A growing body of evidence connects obesity with COVID-19 and a number of mechanisms from immune system activity attenuation to chronic inflammation are implicated. Lipid peroxidation creates reactive lipid aldehydes which in a patient with metabolic disorder and COVID-19 will affect its prognosis. Finally, pregnancy-associated obesity needs to be studied further in connection to COVID-19 as this infection could pose high risk both to pregnant women and the fetus.
C1 [Petrakis, Demetrios; Tsatsakis, Aristidis] Univ Crete, Med Sch, Lab Toxicol, Iraklion 71409, Greece.
   [Margina, Denisa] Carol Davila Univ Med & Pharm, Fac Pharm, Dept Biochem, TraianVuia 6, Bucharest 020956, Romania.
   [Tsarouhas, Konstantinos] Univ Hosp Larissa, Dept Cardiol, Larisa 41110, Greece.
   [Tekos, Fotios; Kouretas, Demetrios] Univ Thessaly, Dept Biochem Biotechnol, Larisa 41500, Greece.
   [Stan, Miriana] Carol Davila Univ Med & Pharm, Fac Pharm, Dept Toxicol, Bucharest 020956, Romania.
   [Nikitovic, Dragana] Univ Crete, Sch Med, Lab Histol Embryol, Iraklion 71003, Greece.
   [Spandidos, Demetrios A.] Univ Crete, Med Sch, Lab Clin Virol, Iraklion 71110, Greece.
C3 University of Crete; Carol Davila University of Medicine & Pharmacy;
   General University Hospital of Larissa; University of Thessaly; Carol
   Davila University of Medicine & Pharmacy; University of Crete;
   University of Crete
RP Tsatsakis, A (corresponding author), Univ Crete, Med Sch, Lab Toxicol, Iraklion 71409, Greece.; Margina, D (corresponding author), Carol Davila Univ Med & Pharm, Fac Pharm, Dept Biochem, TraianVuia 6, Bucharest 020956, Romania.
EM denisa.margina@umfcd.ro; tsatsaka@uoc.gr
RI Stan, Miriana/HKE-0696-2023; Nikitovic, Dragana/AAS-6215-2020; Tekos,
   Fotios/GXG-0844-2022; KOURETAS, DEMETRIOS/ABE-8519-2020; Tsarouhas,
   Konstantinos/H-5793-2019; Margina, Denisa/J-7312-2013; TSATSAKIS,
   ARISTIDIS/H-2890-2013
OI Tsarouhas, Konstantinos/0000-0003-2651-3579; Tekos,
   Fotios/0000-0002-9588-0367; Margina, Denisa/0000-0003-3289-147X;
   TSATSAKIS, ARISTIDIS/0000-0003-3824-2462; Nikitovic,
   Dragana/0000-0003-3882-7399
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NR 170
TC 248
Z9 258
U1 0
U2 58
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1791-2997
EI 1791-3004
J9 MOL MED REP
JI Mol. Med. Rep.
PD JUL
PY 2020
VL 22
IS 1
BP 9
EP 19
DI 10.3892/mmr.2020.11127
PG 11
WC Oncology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Research & Experimental Medicine
GA MB0HE
UT WOS:000542289500001
PM 32377709
OA Green Published, hybrid
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Toker, S
   Gavish, I
   Biron, M
AF Toker, Sharon
   Gavish, Ifat
   Biron, Michal
TI Job Demand-Control-Support and diabetes risk: The moderating role of
   self-efficacy
SO EUROPEAN JOURNAL OF WORK AND ORGANIZATIONAL PSYCHOLOGY
LA English
DT Article
DE Diabetes; Glucose; HbA1C; Job-Demand-Control-Support; Self-efficacy
ID SOCIAL SUPPORT; GLYCATED HEMOGLOBIN; METABOLIC SYNDROME; WORK STRESS;
   STRAIN; PERFORMANCE; DISEASE; IMPACT; MODEL; CONSEQUENCES
AB Work-related stressors, including high demands and low control, play a significant role in the aetiology of diabetes. Nevertheless, most studies focus on main effects, and few consider individual differences that may moderate the stress-health association. Drawing from the Job Demands-Control--Support (JDC-S) model, this study addresses this gap by testing how baseline levels of JDC-S affect an increase in two risk factors for diabetesglycated haemoglobin (HbA1C) and fasting plasma glucose (FPG)and by investigating the moderating role of self-efficacy. Participants (N=1618) were Israeli employees who attended two consecutive routine health examinations. All were free of diabetes at baseline. JDC-S and self-efficacy were assessed at baseline (T1), and HbA1C and FPG were assessed at T1 and T2. Data were analysed with logistic and linear regressions, controlling for well-established diabetes risk factors. High demands and low support predicted an increase in HbA1C and FPG. In addition, high self-efficacy interacted with high demands and with low control in the prediction of an increase in HbA1C and FPG. Although employees with high self-efficacy might function well at work, overloading them may harm their physical health. Similarly, incongruence between employees' sense of ability and the control given to them at work may result in physical impairment.
C1 [Toker, Sharon] Tel Aviv Univ, Fac Management, IL-69978 Tel Aviv, Israel.
   [Gavish, Ifat] Tel Aviv Univ, Dept Psychol, IL-69978 Tel Aviv, Israel.
   [Biron, Michal] Univ Haifa, Grad Sch Management, IL-31999 Haifa, Israel.
C3 Tel Aviv University; Tel Aviv University; University of Haifa
RP Toker, S (corresponding author), Tel Aviv Univ, Fac Management, IL-69978 Tel Aviv, Israel.
EM tokersha@post.tau.ac.il
RI Biron, Michal/HPG-8347-2023; Toker, Sharon/P-5428-2015
OI Biron, Michal/0000-0002-3364-2566; Toker, Sharon/0000-0001-7621-6607
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NR 78
TC 7
Z9 11
U1 1
U2 37
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 1359-432X
EI 1464-0643
J9 EUR J WORK ORGAN PSY
JI Eur. J. Work Organ. Psychol.
PD DEC 1
PY 2013
VL 22
IS 6
BP 711
EP 724
DI 10.1080/1359432X.2012.698058
PG 14
WC Psychology, Applied; Management
WE Social Science Citation Index (SSCI)
SC Psychology; Business & Economics
GA 243XT
UT WOS:000326352400006
DA 2025-06-11
ER

PT J
AU Dinwiddie, GY
   Zambrana, RE
   Garza, MA
AF Dinwiddie, Gniesha Y.
   Zambrana, Ruth E.
   Garza, Mary A.
TI Exploring Risk Factors in Latino Cardiovascular Disease: The Role of
   Education, Nativity, and Gender
SO AMERICAN JOURNAL OF PUBLIC HEALTH
LA English
DT Article
ID BODY-MASS INDEX; SELF-RATED HEALTH; RESIDENTIAL SEGREGATION;
   NATIONAL-HEALTH; HYPERTENSION PREVALENCE; WAIST CIRCUMFERENCE; METABOLIC
   SYNDROME; PHYSICAL-ACTIVITY; BIOLOGICAL RISK; BLOOD-PRESSURE
AB Objectives. We examined 3 cardiovascular disease risk factors by nativity and gender, evaluating evidence for education and health behaviors in explaining the "Hispanic Health Paradox."
   Methods. We analyzed 2001-2008 National Health and Nutrition Examination Survey data for adults (n = 6032) to compare hypertension, high waist circumference, and diabetes for US- and foreign-born Mexican men and women. We controlled for age, depression, and health insurance.
   Results. Cardiovascular disease risk factors differed by education, nativity, and gender. Higher education was associated with higher odds of hypertension and high waist circumference for men and women regardless of nativity. As education increased, the odds of diabetes increased for US-born women, showing a gradient for this population. Finally, foreign-born Mexican women with 5 to 19 years in the United States conferred the highest odds of having diabetes, whereas foreign-born men with less than 5 years in the United States had the lowest odds for high waist circumference and presence of diabetes.
   Conclusions. Results contest assumptions of the Hispanic Health Paradox and suggest new approaches. New research can yield accurate information to ensure the development of appropriate interventions, decreasing health disparities endemic to a subgroup of Latinos.
C1 [Dinwiddie, Gniesha Y.] Univ Maryland, African Amer Studies Dept, College Pk, MD 20742 USA.
   [Dinwiddie, Gniesha Y.] Univ Maryland, Maryland Populat Res Ctr, College Pk, MD 20742 USA.
   [Zambrana, Ruth E.] Univ Maryland, Dept Womens Studies, College Pk, MD 20742 USA.
   [Zambrana, Ruth E.] Univ Maryland, Consortium Race Gender & Ethn, College Pk, MD 20742 USA.
   [Garza, Mary A.] Univ Maryland, Dept Behav & Community Hlth, College Pk, MD 20742 USA.
   [Garza, Mary A.] Univ Maryland, Maryland Ctr Hlth Equ, College Pk, MD 20742 USA.
C3 University System of Maryland; University of Maryland College Park;
   University System of Maryland; University of Maryland College Park;
   University System of Maryland; University of Maryland College Park;
   University System of Maryland; University of Maryland College Park;
   University System of Maryland; University of Maryland College Park;
   University System of Maryland; University of Maryland College Park
RP Dinwiddie, GY (corresponding author), Univ Maryland, 1119 Taliaferro Hall, College Pk, MD 20742 USA.
EM gnieshad@umd.edu
RI Zambrana, Ruth Enid/ABD-5509-2020
FU National Institutes of Health Division of Health Disparities Loan
   Repayment Program; Mentored Research Scientist Development Award
   [K01CA140358]
FX This research was supported by the National Institutes of Health
   Division of Health Disparities Loan Repayment Program (to G. Y. D.). M.
   A. Garza was supported, in part, through her Mentored Research Scientist
   Development Award to Promote Diversity (K01CA140358).
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   Zsembik BA, 2005, SOC SCI MED, V61, P53, DOI 10.1016/j.socscimed.2004.11.040
NR 67
TC 21
Z9 33
U1 0
U2 13
PU AMER PUBLIC HEALTH ASSOC INC
PI WASHINGTON
PA 800 I STREET, NW, WASHINGTON, DC 20001-3710 USA
SN 0090-0036
EI 1541-0048
J9 AM J PUBLIC HEALTH
JI Am. J. Public Health
PD SEP
PY 2014
VL 104
IS 9
BP 1742
EP 1750
DI 10.2105/AJPH.2013.301280
PG 9
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA AP1XB
UT WOS:000341864400043
PM 24028268
OA Green Accepted, Green Published
DA 2025-06-11
ER

PT J
AU Grant, WB
AF Grant, William B.
TI Does Vitamin D Reduce the Risk of Dementia?
SO JOURNAL OF ALZHEIMERS DISEASE
LA English
DT Review
DE Alzheimer's disease; cardiovascular disease; cathelicidin; periodontal
   disease; tooth loss; ultraviolet-B; vitamin D; vascular dementia
ID SERUM 25-HYDROXYVITAMIN-D LEVELS; MILD COGNITIVE IMPAIRMENT; GLYCATION
   END-PRODUCTS; 3RD NATIONAL-HEALTH; ALZHEIMERS-DISEASE; D DEFICIENCY;
   DEPRESSIVE SYMPTOMS; METABOLIC SYNDROME; TOOTH EXTRACTIONS; VASCULAR
   DEMENTIA
AB The understanding of the role of vitamin D in maintaining optimal health has advanced sharply in the past two decades. There is mounting evidence for beneficial roles for vitamin D in reducing the risk of bone diseases and fractures, many types of cancer, bacterial and viral infections, autoimmune diseases, and cardiovascular diseases. Recently, several reports have also been published regarding the role of vitamin D in neuroprotection. This article develops the hypothesis that vitamin D can reduce the risk of developing dementia, presenting the evidence from observational and laboratory studies. The observational evidence includes that low serum 25-hydroxyvitamin D [25(OH)D] has been associated with increased risk for cardiovascular diseases, diabetes mellitus, depression, dental caries, osteoporosis, and periodontal disease, all of which are either considered risk factors for dementia or have preceded incidence of dementia. The laboratory evidence includes several findings on the role of vitamin D in neuroprotection and reducing inflammation. Although this evidence is supportive, there do not appear to be observational studies of incidence of dementia with respect to prediagnostic serum 25(OH)D or vitamin D supplementation. Such studies now appear to be warranted.
C1 Sunlight Nutr & Hlth Res Ctr SUNARC, San Francisco, CA 94164 USA.
RP Grant, WB (corresponding author), Sunlight Nutr & Hlth Res Ctr SUNARC, POB 641603, San Francisco, CA 94164 USA.
EM wbgrant@infionline.net
RI Grant, William/B-8311-2009
OI Grant, William/0000-0002-1439-3285
FU UV Foundation; Vitamin D Society (Canada); European Sunlight Association
   (Brussels)
FX Dr. Grant receives funding from the UV Foundation (McLean, VA), the
   Vitamin D Society (Canada), and the European Sunlight Association
   (Brussels).
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NR 110
TC 52
Z9 57
U1 0
U2 25
PU IOS PRESS
PI AMSTERDAM
PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS
SN 1387-2877
EI 1875-8908
J9 J ALZHEIMERS DIS
JI J. Alzheimers Dis.
PY 2009
VL 17
IS 1
BP 151
EP 159
DI 10.3233/JAD-2009-1024
PG 9
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 461RS
UT WOS:000267289200015
PM 19494440
DA 2025-06-11
ER

PT J
AU Ruskovska, T
   Maksimova, 
   Milenkovic, D
AF Ruskovska, T.
   Maksimova, V
   Milenkovic, D.
TI Polyphenols in human nutrition: from the in vitro antioxidant
   capacity to the beneficial effects on cardiometabolic health and related
   inter-individual variability - an overview and perspective
SO BRITISH JOURNAL OF NUTRITION
LA English
DT Review
DE Polyphenols; Antioxidants; Cell signalling; Nutrigenomics;
   Cardiometabolic health
ID RED WINE POLYPHENOLS; MAJOR FOOD SOURCES; OXIDATIVE STRESS; VITAMIN-E;
   DIETARY-INTAKE; DOUBLE-BLIND; CARDIOVASCULAR-DISEASE; OLIVE OIL;
   ENDOTHELIAL FUNCTION; INSULIN SENSITIVITY
AB Oxidative damage of cells and tissues is broadly implicated in human pathophysiology, including cardiometabolic diseases. Polyphenols, as important constituents of the human diet and potent in vitro free radical scavengers, have been extensively studied for their beneficial effects on cardiometabolic health. However, it has been demonstrated that the in vivo antioxidant activity of polyphenols is distinct from their in vitro free radical-scavenging capacity. Indeed, bioavailability of nutritional polyphenols is low and conditioned by complex mechanisms of absorption, distribution, metabolism and excretion. Nowadays, it is commonly accepted that the cellular antioxidant activity of polyphenols is mainly carried out via modification of transcription of genes involved in antioxidant defence. Importantly, polyphenols also contribute to cardiometabolic health by modulation of a plethora of cellular processes that are not directly associated with antioxidant enzymes, through nutri(epi)genomic mechanisms. Numerous human intervention studies have demonstrated beneficial effects of polyphenols on the key cardiometabolic risk factors. However, inconsistency of the results of some studies led to identification of the inter-individual variability in response to consumption of polyphenols. In perspective, a detailed investigation of the determinants of this inter-individual variability will potentially lead us towards personalised dietary recommendations. The phenomenon of inter-individual variability is also of relevance for supplementation with antioxidant (pro)vitamins.
C1 [Ruskovska, T.; Maksimova, V] Univ Goce Delcev, Fac Med Sci, Stip 2000, North Macedonia.
   [Milenkovic, D.] Univ Calif Davis, Sch Med, Div Cardiovasc Med, Dept Internal Med, Davis, CA 95616 USA.
   [Milenkovic, D.] Univ Clermont Auvergne, INRA, UNH, CRNH Auvergne, F-63000 Clermont Ferrand, France.
C3 Goce Delcev University of Stip; University of California System;
   University of California Davis; INRAE; Universite Clermont Auvergne
   (UCA)
RP Ruskovska, T (corresponding author), Univ Goce Delcev, Fac Med Sci, Stip 2000, North Macedonia.
EM tatjana.ruskovska@ugd.edu.mk
RI Ruskovska, Tatjana/V-4885-2019; Maksimova, Viktorija/JJF-0113-2023
OI Milenkovic, Dragan/0000-0001-6353-0912; Maksimova,
   Viktorija/0009-0001-6986-3213
FU COST (European Cooperation in Science and Technology)
FX The authors are members of COST Action FA1403-POSITIVe 'Interindividual
   variation in response to consumption of plant food bioactives and
   determinants involved' supported by COST (European Cooperation in
   Science and Technology, http://www.cost.eu/).
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NR 117
TC 78
Z9 82
U1 5
U2 79
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1145
EI 1475-2662
J9 BRIT J NUTR
JI Br. J. Nutr.
PD FEB 14
PY 2020
VL 123
IS 3
BP 241
EP 254
AR PII S0007114519002733
DI 10.1017/S0007114519002733
PG 14
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA KH2NZ
UT WOS:000510485900001
PM 31658907
OA Green Submitted, Bronze
DA 2025-06-11
ER

PT J
AU Choi, J
   Han, IK
   Min, JH
   Yun, JS
   Kim, BS
   Shin, K
   Kim, K
   Kim, YH
AF Choi, Jeeyu
   Han, Ikjoon
   Min, Joohong
   Yun, Jisang
   Kim, Byung-Soo
   Shin, Kihyuk
   Kim, Kihun
   Kim, Yun Hak
TI Dose-response analysis between alcohol consumption and psoriasis: A
   systematic review and meta-analysis
SO JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT
LA English
DT Review
DE Alcohol consumption; systematic review; Alcohol consumption; psoriasis;
   dose-response analysis; meta-analysis; psoriasis; systematic review
ID CARDIOVASCULAR RISK-FACTORS; METABOLIC SYNDROME; CIGARETTE-SMOKING; LIFE
   EVENTS; PREVALENCE; POPULATION; ARTHRITIS; COMORBIDITIES; DEPRESSION;
   QUALITY
AB The association between psoriasis and alcohol consumption has been inconsistent across various studies. However, to the best of our knowledge, no dose-response meta-analysis has been performed to date. This study aims to investigate the association between alcohol consumption and psoriasis. The search was performed on July 27, 2021, using Embase and MEDLINE. The restricted cubic spline analysis was used to perform a dose-response analysis. We identified 3,904 studies, of which 48 studies with 1,702,847 individuals across 24 countries were included. Alcohol consumption was positively associated with psoriasis (odds ratio [OR], 1.47; 95% confidence interval [CI], 1.27-1.70). In addition, a significantly increased OR for psoriasis was observed in males (OR, 1.84; 95% CI, 1.13-3.01) but not in females (OR, 1.22; 95% CI, 0.97-1.54). Based on eight studies, including three cohort and five case-control studies, the analysis revealed that with each additional gram of daily alcohol intake, the OR for psoriasis increased by 4%. We found a positive association between alcohol consumption and psoriasis. The association is more prominent in the group drinking more than 45 g of alcohol per day (3.2 alcoholic drink equivalent).
C1 [Choi, Jeeyu; Han, Ikjoon; Min, Joohong] Pusan Natl Univ, Sch Dent, Yangsan 50612, South Korea.
   [Yun, Jisang; Kim, Byung-Soo; Shin, Kihyuk] Pusan Natl Univ, Coll Med, Dept Dermatol, Pusan, South Korea.
   [Yun, Jisang; Shin, Kihyuk] Pusan Natl Univ, Yangsan Hosp, Dept Dermatol, Yangsan, South Korea.
   [Shin, Kihyuk] Pusan Natl Univ, Yangsan Hosp, Res Inst Convergence Biomed Sci & Technol, Yangsan, South Korea.
   [Kim, Kihun; Kim, Yun Hak] Pusan Natl Univ, Sch Med, Dept Biomed Informat, Yangsan, South Korea.
   [Kim, Kihun; Kim, Yun Hak] Pusan Natl Univ, Sch Med, Dept Anat, Yangsan, South Korea.
   Pusan Natl Univ, Dept Anat, Dept Biomed Informat, Yangsan 50612, South Korea.
C3 Pusan National University; Pusan National University; Pusan National
   University; Pusan National University Hospital; Pusan National
   University; Pusan National University Hospital; Pusan National
   University; Pusan National University Hospital; Pusan National
   University; Pusan National University Hospital; Pusan National
   University
RP Shin, K (corresponding author), Pusan Natl Univ, Coll Med, Dept Dermatol, Pusan, South Korea.; Shin, K (corresponding author), Pusan Natl Univ, Yangsan Hosp, Dept Dermatol, Yangsan, South Korea.; Shin, K (corresponding author), Pusan Natl Univ, Yangsan Hosp, Res Inst Convergence Biomed Sci & Technol, Yangsan, South Korea.; Kim, K; Kim, YH (corresponding author), Pusan Natl Univ, Sch Med, Dept Biomed Informat, Yangsan, South Korea.; Kim, K; Kim, YH (corresponding author), Pusan Natl Univ, Sch Med, Dept Anat, Yangsan, South Korea.
EM teriakiller@hanmail.net; kihun7603@naver.com; yunhak10510@pusan.ac.kr
RI Kim, Yun Hak/ABF-3331-2021; Kim, Dennis/AAH-8499-2019
OI Kim, Yun Hak/0000-0002-9796-8266; kim, kihun/0000-0001-6445-6881
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NR 86
TC 1
Z9 1
U1 2
U2 10
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1610-0379
EI 1610-0387
J9 J DTSCH DERMATOL GES
JI J. Dtsch. Dermatol. Ges.
PD MAY
PY 2024
VL 22
IS 5
BP 641
EP 653
DI 10.1111/ddg.15380
EA APR 2024
PG 13
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA RU2C5
UT WOS:001209410100001
PM 38679782
DA 2025-06-11
ER

PT J
AU Pedersen, BK
AF Pedersen, Bente K.
TI The diseasome of physical inactivity - and the role of myokines in
   muscle-fat cross talk
SO JOURNAL OF PHYSIOLOGY-LONDON
LA English
DT Article; Proceedings Paper
CT 36th International Congress of Physiological Sciences
CY JUL 31, 2009
CL Kyoto, JAPAN
ID TYPE-2 DIABETES-MELLITUS; NEUROTROPHIC FACTOR; SKELETAL-MUSCLE;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; BREAST-CANCER; PLASMA-LEVELS;
   COLON-CANCER; TNF-ALPHA; ALL-CAUSE
AB Type 2 diabetes, cardiovascular diseases, colon cancer, breast cancer, dementia and depression constitute a cluster of diseases, which defines 'a diseasome of physical inactivity'. Both physical inactivity and abdominal adiposity, reflecting accumulation of visceral fat mass, are associated with the occurrence of the diseases within the diseasome. Physical inactivity appears to be an independent and strong risk factor for accumulation of visceral fat, which again is a source of systemic inflammation. Chronic inflammation is involved in the pathogenesis of insulin resistance, atherosclerosis, neurodegeneration and tumour growth. Evidence suggests that the protective effect of exercise may to some extent be ascribed to the anti-inflammatory effect of regular exercise, which can be mediated via a reduction in visceral fat mass and/or by induction of an anti-inflammatory environment with each bout of exercise. The finding that muscles produce and release myokines provides a conceptual basis to understand the mechanisms whereby exercise influences metabolism and exerts anti-inflammatory effects. According to our theory, contracting skeletal muscles release myokines, which work in a hormone-like fashion, exerting specific endocrine effects on visceral fat. Other myokines work locally within the muscle via paracrine mechanisms, exerting their effects on signalling pathways involved in fat oxidation.
C1 [Pedersen, Bente K.] Univ Copenhagen, Rigshosp, Dept Infect Dis, Ctr Inflammat & Metab,Fac Hlth Sci, DK-2100 Copenhagen, Denmark.
   [Pedersen, Bente K.] Univ Copenhagen, Rigshosp, Fac Hlth Sci, Copenhagen Muscle Res Ctr, DK-2100 Copenhagen, Denmark.
C3 University of Copenhagen; Copenhagen University Hospital;
   Rigshospitalet; Rigshospitalet; University of Copenhagen; Copenhagen
   University Hospital
RP Pedersen, BK (corresponding author), Univ Copenhagen, Rigshosp, Dept Infect Dis, Ctr Inflammat & Metab,Fac Hlth Sci, Sect 7641,Blegdamsvej 9, DK-2100 Copenhagen, Denmark.
EM bkp@rh.dk
RI Pedersen, Bente/AGR-3217-2022
OI Pedersen, Bente Klarlund/0000-0001-6508-6288
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NR 60
TC 442
Z9 510
U1 0
U2 36
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-3751
EI 1469-7793
J9 J PHYSIOL-LONDON
JI J. Physiol.-London
PD DEC 1
PY 2009
VL 587
IS 23
BP 5559
EP 5568
DI 10.1113/jphysiol.2009.179515
PG 10
WC Neurosciences; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Neurosciences & Neurology; Physiology
GA 526QO
UT WOS:000272307800013
PM 19752112
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Meroni, M
   Longo, M
   Dongiovanni, P
AF Meroni, Marica
   Longo, Miriam
   Dongiovanni, Paola
TI Cardiometabolic risk factors in MASLD patients with HCC: the other side
   of the coin
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Review
DE MASLD; HCC; metabolic dysfunctions; cholesterol; carotid plaques
ID FATTY LIVER-DISEASE; POPULATION-ATTRIBUTABLE FRACTIONS;
   HEPATOCELLULAR-CARCINOMA; NONALCOHOLIC STEATOHEPATITIS; PROGNOSTIC
   BIOMARKER; FREE-CHOLESTEROL; HEART-FAILURE; EARLY-STAGE; PERILIPIN 5;
   APO-B
AB Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) constitutes the commonest cause of chronic liver disorder worldwide, whereby affecting around one third of the global population. This clinical condition may evolve into Metabolic Dysfunction-Associated Steatohepatitis (MASH), fibrosis, cirrhosis and hepatocellular carcinoma (HCC), in a predisposed subgroup of patients. The complex pathogenesis of MASLD is severely entangled with obesity, dyslipidemia and type 2 diabetes (T2D), so far so nutritional and lifestyle recommendations may be crucial in influencing the risk of HCC and modifying its prognosis. However, the causative association between HCC onset and the presence of metabolic comorbidities is not completely clarified. Therefore, the present review aimed to summarize the main literature findings that correlate the presence of inherited or acquired hyperlipidemia and metabolic risk factors with the increased predisposition towards liver cancer in MASLD patients. Here, we gathered the evidence underlining the relationship between circulating/hepatic lipids, cardiovascular events, metabolic comorbidities and hepatocarcinogenesis. In addition, we reported previous studies supporting the impact of triglyceride and/or cholesterol accumulation in generating aberrancies in the intracellular membranes of organelles, oxidative stress, ATP depletion and hepatocyte degeneration, influencing the risk of HCC and its response to therapeutic approaches. Finally, our pursuit was to emphasize the link between HCC and the presence of cardiometabolic abnormalities in our large cohort of histologically-characterized patients affected by MASLD (n=1538), of whom 86 had MASLD-HCC by including unpublished data.
C1 [Meroni, Marica; Longo, Miriam; Dongiovanni, Paola] Fdn IRCCS Ca Granda Osped Maggiore Policlin, Med & Metab Dis, Milan, Italy.
C3 IRCCS Ca Granda Ospedale Maggiore Policlinico
RP Meroni, M; Longo, M (corresponding author), Fdn IRCCS Ca Granda Osped Maggiore Policlin, Med & Metab Dis, Milan, Italy.
EM marica.meroni@policlinico.mi.it; miriam.longo@policlinico.mi.it
RI Longo, Miriam/AAB-3817-2019; Dongiovanni, Paola/AAC-9965-2019; meroni,
   marica/K-8621-2018
FU Italian Ministry of Health (Ricerca Corrente 2024 -Fondazione IRCCS Ca
   Granda Ospedale Maggiore Policlinico); Italian Ministry of Health
   (Ricerca Finalizzata Ministero della Salute [GR-2019-12370172,
   RF-2021-12374481]; Fondazione IRCCS Ca Granda Ospedale Maggiore
   Policlinico [RC5100020B]
FX The author(s) declare that financial support was received for the
   research, authorship, and/or publication of this article. This study was
   supported by Italian Ministry of Health (Ricerca Corrente 2024
   -Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico), by Italian
   Ministry of Health (Ricerca Finalizzata Ministero della Salute
   GR-2019-12370172; RF-2021-12374481) and by 5x1000 2020 -Fondazione IRCCS
   Ca Granda Ospedale Maggiore Policlinico (RC5100020B).
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NR 130
TC 4
Z9 4
U1 0
U2 2
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD MAY 23
PY 2024
VL 15
AR 1411706
DI 10.3389/fendo.2024.1411706
PG 13
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA TM8Z5
UT WOS:001241785600001
PM 38846491
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Marcil, V
   Mayeur, S
   Lamarche, B
   England, J
   Henderson, M
   Delvin, E
   Amre, D
   Levy, E
AF Marcil, Valerie
   Mayeur, Sylvain
   Lamarche, Benoit
   England, Jade
   Henderson, Melanie
   Delvin, Edgard
   Amre, Devendra
   Levy, Emile
TI Cardiometabolic risk factors and lactoferrin: polymorphisms and plasma
   levels in French-Canadian children
SO PEDIATRIC RESEARCH
LA English
DT Article
ID SINGLE-NUCLEOTIDE POLYMORPHISM; LTF GENE; AGGRESSIVE PERIODONTITIS;
   CIRCULATING LACTOFERRIN; OXIDATIVE STRESS; VISCERAL FAT; ASSOCIATION;
   SUSCEPTIBILITY; ACCUMULATION; CHOLESTEROL
AB BACKGROUND: Lactoferrin (LTF) could play a beneficial role in insulin resistance and diabetes, but the association of its gene variants with cardio-metabolic disorders in children has not been investigated. This study aimed to examine the relationship between LTF variants, plasma LTF concentrations, and cardio-metabolic risk factors in French-Canadian children.
   METHODS: The study cohort comprises 1,749 French Canadians aged 9, 13, and 16 years. The association of 13 LTF polymorphisms, metabolic parameters, and plasma LTF levels was tested in this cross-sectional, province-wide schoolbased survey.
   RESULTS: None of the genetic association remained significant after correction for multiple testing and LTF SNPs were not associated with LTF levels. Plasma LTF was positively correlated with body mass index (r(2) = 0.2245, P = 0.0011) and weight (r(2) = 0.2515, P = 0.0008). After segregating according to high-density lipoprotein cholesterol (HDL-C), the association remained only in subjects exhibiting low HDL-C (r(2) = 0.3868, P = 0.0002 for body mass index and r(2) = 0.3665, P = 0.0004 for weight). In girls, plasma LTF was positively correlated with total cholesterol (r(2) = 0.2231, P = 0.0378), LDL cholesterol (r(2) = 0.2409, P = 0.0246), and apolipoprotein B (r(2) = 0.2478, P = 0.0207).
   CONCLUSIONS: We found no association between LTF gene variants and metabolic parameters following correction for multiple testing. HDL-C and gender-specific positive associations were evidenced between plasma LTF, anthropometric profile, and lipid levels.
C1 [Mayeur, Sylvain; Delvin, Edgard] Univ Montreal, Res Ctr, CHU St Justine, Montreal, PQ, Canada.
   [Marcil, Valerie; Levy, Emile] Univ Montreal, Dept Nutr, Montreal, PQ, Canada.
   [Lamarche, Benoit] Laval Univ, Inst Nutr & Funct Foods INAF, Quebec City, PQ, Canada.
   [England, Jade; Henderson, Melanie; Amre, Devendra] Univ Montreal, Dept Pediat, Montreal, PQ, Canada.
C3 Universite de Montreal; Centre Hospitalier Universitaire Sainte-Justine;
   Universite de Montreal; Laval University; Universite de Montreal
RP Levy, E (corresponding author), Univ Montreal, Dept Nutr, Montreal, PQ, Canada.
EM emile.levy@recherche-ste-Justine.qc.ca
RI AMRE, DEVENDRA/D-4988-2015; Lamarche, Benoit/ABA-4785-2021
OI Lamarche, Benoit/0000-0002-4443-5378
FU Dairy Farmers of Canada; Canadian Institutes of Health Research; Richard
   and Edith Strauss Postdoctoral Fellowships Award in Medicine, McGill
   University
FX This work was supported by grants from the Dairy Farmers of Canada and
   J.A. de Seve Research Chair in Nutrition (E.L.), the Canadian Institutes
   of Health Research Fellowship Award and The Richard and Edith Strauss
   Postdoctoral Fellowships Award in Medicine, McGill University (V.M.).
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NR 30
TC 8
Z9 8
U1 0
U2 4
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 0031-3998
EI 1530-0447
J9 PEDIATR RES
JI Pediatr. Res.
PD NOV
PY 2017
VL 82
IS 5
BP 741
EP 748
DI 10.1038/pr.2017.72
PG 8
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA FK8CF
UT WOS:000413734300006
PM 28678770
OA Bronze
DA 2025-06-11
ER

PT J
AU Sarlon, E
   Millier, A
   Aballéa, S
   Toumi, M
AF Sarlon, E.
   Millier, A.
   Aballea, S.
   Toumi, M.
TI Evaluation of Different Approaches for Confounding in Nonrandomised
   Observational Data: A Case-Study of Antipsychotics Treatment
SO COMMUNITY MENTAL HEALTH JOURNAL
LA English
DT Article
DE Confounding; Propensity score; Schizophrenia; Antipsychotic
ID PROPENSITY SCORE METHODS; CALGARY-DEPRESSION-SCALE; RATING-SCALE;
   METABOLIC SYNDROME; SCHIZOPHRENIA; POLYPHARMACY; MORTALITY; ADJUSTMENT;
   REGRESSION; MEDICATION
AB Although randomised controlled trials are regarded as the gold standard for treatments efficacy, evidence from observational studies remains relevant. To address the problem of possible confounding in these studies, investigators must employ analysis methods that adjust for confounders and lead to an unbiased estimation of the treatment effect. In this paper, the authors describe two relevant statistical methods. The first method represents the classical approach consisting of a multiple regression model including the effects of treatment and covariates. This approach considers the relation between prognostic factors and the outcome variable as a relevant criterion for adjustment. The second method is based on the propensity score, and focuses on the relation between prognostic factors and treatment assignment. These approaches were applied to a cohort of 183 French schizophrenic patients who were followed for a 2-year period (from 1998 to 2000). The probability of relapse according to antipsychotic treatment exposure was modelled using Cox regression models with the two statistical methods. Goodness-of-fit criteria were used to compare the modelling approaches. This study demonstrates that the propensity score, a predicted probability, has an important balancing property that underscores its value in strengthening the results of nonrandomised observational studies.
C1 [Sarlon, E.] Natl Inst Hlth & Med Res, INSERM, U669, Paris, France.
   [Sarlon, E.] Univ Paris 11, UMR S0669, Paris, France.
   [Sarlon, E.] Univ Paris 05, Paris, France.
   [Sarlon, E.] GHPSO, Dept Publ Hlth, Oise, France.
   [Sarlon, E.] Grp Hosp Publ Sud Oise, DIM, F-60109 Creil, France.
   [Millier, A.; Aballea, S.; Toumi, M.] Creat Ceut, Paris, France.
   [Toumi, M.] Univ Lyon 1, F-69365 Lyon, France.
C3 Institut National de la Sante et de la Recherche Medicale (Inserm);
   Universite Paris Cite; Universite Paris Saclay; Universite Paris Cite;
   Universite Paris Cite; Universite Claude Bernard Lyon 1
RP Sarlon, E (corresponding author), Grp Hosp Publ Sud Oise, DIM, Blvd Laennec, F-60109 Creil, France.
EM emmanuelle.sarlon@gmail.com
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NR 69
TC 0
Z9 0
U1 0
U2 3
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0010-3853
EI 1573-2789
J9 COMMUNITY MENT HLT J
JI Community Ment. Health J.
PD AUG
PY 2014
VL 50
IS 6
BP 711
EP 720
DI 10.1007/s10597-014-9723-x
PG 10
WC Health Policy & Services; Public, Environmental & Occupational Health;
   Psychiatry
WE Social Science Citation Index (SSCI)
SC Health Care Sciences & Services; Public, Environmental & Occupational
   Health; Psychiatry
GA AL8IS
UT WOS:000339382400012
PM 24696151
DA 2025-06-11
ER

PT J
AU Capasso, L
   De Masi, L
   Sirignano, C
   Maresca, V
   Basile, A
   Nebbioso, A
   Rigano, D
   Bontempo, P
AF Capasso, Lucia
   De Masi, Luigi
   Sirignano, Carmina
   Maresca, Viviana
   Basile, Adriana
   Nebbioso, Angela
   Rigano, Daniela
   Bontempo, Paola
TI Epigallocatechin Gallate (EGCG): Pharmacological Properties, Biological
   Activities and Therapeutic Potential
SO MOLECULES
LA English
DT Review
DE epigallocatechin gallate; biological activity; pharmacological activity;
   preventive activity; human pathologies
ID GREEN TEA POLYPHENOL; HEPATITIS-B-VIRUS; INSULIN-RESISTANCE; OXIDATIVE
   STRESS; (-)-EPIGALLOCATECHIN-3-GALLATE EGCG; SIGNALING PATHWAYS;
   LIPID-PEROXIDATION; METABOLIC SYNDROME; GROWTH-INHIBITION; LAMININ
   RECEPTOR
AB Epigallocatechin gallate (EGCG), the predominant catechin in green tea, comprises approximately 50% of its total polyphenol content and has garnered widespread recognition for its significant therapeutic potential. As the principal bioactive component of Camellia sinensis, EGCG is celebrated for its potent antioxidant, anti-inflammatory, cardioprotective, and antitumor properties. The bioavailability and metabolism of EGCG within the gut microbiota underscore its systemic effects, as it is absorbed in the intestine, metabolized into bioactive compounds, and transported to target organs. This compound has been shown to influence key physiological pathways, particularly those related to lipid metabolism and inflammation, offering protective effects against a variety of diseases. EGCG's ability to modulate cell signaling pathways associated with oxidative stress, apoptosis, and immune regulation highlights its multifaceted role in health promotion. Emerging evidence underscores EGCG's therapeutic potential in preventing and managing a range of chronic conditions, including cancer, cardiovascular diseases, neurodegenerative disorders, and metabolic syndromes. Given the growing prevalence of lifestyle-related diseases and the increasing interest in natural compounds, EGCG presents a promising avenue for novel therapeutic strategies. This review aims to summarize current knowledge on EGCG, emphasizing its critical role as a versatile natural bioactive agent with diverse clinical applications. Further exploration in both experimental and clinical settings is essential to fully unlock its therapeutic potential.
C1 [Capasso, Lucia; Nebbioso, Angela; Bontempo, Paola] Univ Campania Luigi Vanvitelli, Dept Precis Med, Via L Crecchio 7, I-80138 Naples, Italy.
   [De Masi, Luigi] Natl Res Council CNR, Inst Biosci & BioResources IBBR, Via Univ 133, I-80055 Portici, Italy.
   [Sirignano, Carmina; Rigano, Daniela] Univ Naples Federico II, Sch Med & Surg, Dept Pharm, Via Domen Montesano 49, I-80131 Naples, Italy.
   [Maresca, Viviana] Link Campus Univ, Dept Life Sci Hlth & Hlth Profess, I-00165 Rome, Italy.
   [Basile, Adriana] Univ Naples Federico II, Dept Biol, I-80126 Naples, Italy.
C3 Universita della Campania Vanvitelli; Consiglio Nazionale delle Ricerche
   (CNR); Istituto di Bioscienze e Biorisorse (IBBR-CNR); University of
   Naples Federico II; University of Naples Federico II
RP Bontempo, P (corresponding author), Univ Campania Luigi Vanvitelli, Dept Precis Med, Via L Crecchio 7, I-80138 Naples, Italy.; Rigano, D (corresponding author), Univ Naples Federico II, Sch Med & Surg, Dept Pharm, Via Domen Montesano 49, I-80131 Naples, Italy.
EM lucia.capasso2@unicampania.it; luigi.demasi@cnr.it;
   carmina.sirignano@unina.it; v.maresca@unilink.it; adbasile@unina.it;
   angela.nebbioso@unicampania.it; drigano@unina.it;
   paola.bontempo@unicampania.it
RI NEBBIOSO, ANGELA/GVS-1294-2022; Maresca, Viviana/AEP-6443-2022; Capasso,
   Lucia/AIB-4864-2022
OI Maresca, Viviana/0000-0002-4656-320X; Capasso, Lucia/0000-0002-0678-6329
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NR 262
TC 8
Z9 8
U1 24
U2 24
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 1420-3049
J9 MOLECULES
JI Molecules
PD FEB
PY 2025
VL 30
IS 3
AR 654
DI 10.3390/molecules30030654
PG 34
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA W4Y6O
UT WOS:001418652800001
PM 39942757
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Kuhn, K
   Lederman, HM
   McGrath-Morrow, SA
AF Kuhn, Katrina
   Lederman, Howard M.
   McGrath-Morrow, Sharon A.
TI Ataxia-telangiectasia clinical trial landscape and the obstacles to
   overcome
SO EXPERT OPINION ON INVESTIGATIONAL DRUGS
LA English
DT Review
DE Ataxia telangiectasia (A-T); ATM; clinical trial; biomarker; genetic
   intervention
ID STEM-CELL TRANSPLANTATION; N-ACETYL CYSTEINE; OXIDATIVE STRESS;
   DNA-DAMAGE; PRIMARY IMMUNODEFICIENCY; GRANULOMATOUS LESIONS;
   NEUROLOGICAL SYMPTOMS; ATM; LYMPHOMA; BETAMETHASONE
AB IntroductionAtaxia telangiectasia (A-T) is a life-limiting autosomal recessive disease characterized by cerebellar degeneration, ocular telangiectasias, and sinopulmonary disease. Since there is no cure for A-T, the standard of care is primarily supportive.Areas coveredWe review clinical trials available in PubMed from 1990 to 2023 focused on lessening A-T disease burden. These approaches include genetic interventions, such as antisense oligonucleotides, designed to ameliorate disease progression in patients with select mutations. These approaches also include pharmacologic treatments that target oxidative stress, inflammation, and mitochondrial exhaustion, to attenuate neurological progression in A-T. Finally, we discuss the use of biological immunotherapies for the treatment of malignancies and granulomatous disease, along with other supportive therapies being used for the treatment of pulmonary disease and metabolic syndrome.Expert opinionBarriers to successful genetic and pharmacologic interventions in A-T include the need for personalized treatment approaches based on patient-specific ATM mutations and phenotypes, lack of an animal model for the neurologic phenotype, and extreme rarity of disease making large-scale randomized trials difficult to perform. Ongoing efforts are needed to diagnose patients earlier, discover more effective therapies, and include more individuals in clinical trials, with the goal to lessen disease burden and to find a cure for patients with A-T.
C1 [Kuhn, Katrina] Johns Hopkins Univ, Sch Med, Dept Pediat, Baltimore, MD USA.
   [Lederman, Howard M.] Johns Hopkins Sch Med, Eudowood Div Pediat Allergy & Immunol, Baltimore, MD USA.
   [McGrath-Morrow, Sharon A.] Univ Penn, Childrens Hosp Philadelphia, Perelman Sch Med, Div Pulm Med & Sleep, Philadelphia, PA 19104 USA.
C3 Johns Hopkins University; Johns Hopkins University; Johns Hopkins
   Medicine; University of Pennsylvania; Pennsylvania Medicine; Childrens
   Hospital of Philadelphia
RP McGrath-Morrow, SA (corresponding author), Univ Penn, Childrens Hosp Philadelphia, Perelman Sch Med, Div Pulm Med & Sleep, Philadelphia, PA 19104 USA.
EM mcgrathmos@chop.edu
RI McGrath-Morrow, Sharon/JMC-0464-2023
OI Kuhn, Katrina/0000-0003-3668-1293
FU National Institutes of Health (Bethesda, MD, USA) [R01 HL114800]; A-T
   Children's Project;  [R01 FD007605]
FX This manuscript was funded by the National Institutes of Health
   (Bethesda, MD, USA) (SAM: R01 HL114800), R01 FD007605 (SAM, HML), A-T
   Children's Project (SAM, HML).
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NR 121
TC 8
Z9 8
U1 3
U2 22
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1354-3784
EI 1744-7658
J9 EXPERT OPIN INV DRUG
JI Expert Opin. Investig. Drugs
PD AUG 3
PY 2023
VL 32
IS 8
BP 693
EP 704
DI 10.1080/13543784.2023.2249399
EA AUG 2023
PG 12
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA S2BH5
UT WOS:001060340700001
PM 37622329
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Sriset, Y
   Sukkasem, N
   Chatuphonprasert, W
   Jarukamjorn, K
AF Sriset, Yollada
   Sukkasem, Nadta
   Chatuphonprasert, Waranya
   Jarukamjorn, Kanokwan
TI Nephroprotective Effects of Hesperidin and Myricetin Against High-Fat
   Diet Plus Ethanol-Induced Renal Oxidative Damage in Mice
SO REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY
LA English
DT Article
DE Antioxidation; Flavonoids; Glutathione stores; Malondialdehyde;
   Nephroprotection
ID METABOLIC SYNDROME; STRESS; SYSTEM; ROLES
AB Hesperidin and myricetin are natural flavonoids that exhibit antioxidant activity, but their effects against high-fat diet plus ethanol-induced renal oxidative damage have never been described. The present study investigated the nephroprotective effects of hesperidin and myricetin on the oxidant-antioxidant system in kidneys of high-fat diet and ethanol (HFDE)-fed mice. Five-week-old female ICR mice were fed a high-fat diet (60 kcal% fat) with daily force feeding of ethanol (500 mg/kg/day) in combination with either hesperidin (50 and 200 mg/kg/day), myricetin (50 and 200 mg/kg/day), or fenofibrate (100 mg/kg/day; positive control) for 60 days. High-fat diet plus ethanol increased malondialdehyde levels in the kidneys. indicating renal oxidative stress, and also disturbed the antioxidative system in the kidneys, reducing superoxide dismutase, catalase, and glutathione peroxidase activities and creating an imbalance of glutathione stores by substantially decreasing the ratio of reduced to oxidized glutathione. Hesperidin, myricetin, and fenofibrate significantly attenuated the high-fat diet plus ethanol-induced renal oxidative damage by restoring malondialdehyde levels, increasing superoxide dismutase, catalase, and glutathione peroxidase activities and rebalancing glutathione stores in the kidneys. These findings suggest that hesperidin and myricetin exert nephroprotective activity through improvement of the renal antioxidative defense machinery at levels comparable to the standard drug fenofibrate. Therefore, hesperidin and myricetin are promising candidates for further development as antioxidant/nephroprotective health supplements.
C1 [Sriset, Yollada; Sukkasem, Nadta; Jarukamjorn, Kanokwan] Khon Kaen Univ, Fac Pharmaceut Sci, Res Grp Pharmaceut Act Nat Prod Using Pharmaceut, Khon Kaen 40002, Thailand.
   [Sriset, Yollada] Rajamangala Univ Technol, Fac Nat Resources, Thai Tradit Med Program, Isan Sakon Nakhon Campus, Sakon Nakhon 47160, Thailand.
   [Chatuphonprasert, Waranya] Mahasarakham Univ, Fac Med, Maha Sarakham 44000, Thailand.
C3 Khon Kaen University; Rajamangala University of Technology Thanyaburi;
   Mahasarakham University
RP Jarukamjorn, K (corresponding author), Khon Kaen Univ, Fac Pharmaceut Sci, Res Grp Pharmaceut Act Nat Prod Using Pharmaceut, Khon Kaen 40002, Thailand.
EM kanok_ja@kku.ac.th
RI Chatuphonprasert, Waranya/AAB-5758-2022; JARUKAMJORN,
   Prof.Dr.Kanokwan/GPP-3420-2022
OI Jarukamjorn, Kanokwan/0000-0001-8774-2733; Chatuphonprasert,
   Waranya/0000-0002-0224-7651; Sukkasem, Nadta/0000-0002-0405-7464;
   Sriset, Yollada/0000-0003-0225-1367
FU Research Group for Pharmaceutical Activities of Natural Products using
   Pharmaceutical Biotechnology [PANPB2563]; Faculty of Pharmaceutical
   Sciences, Khon Kaen University, Thailand
FX This work was supported by the Research Group for Pharmaceutical
   Activities of Natural Products using Pharmaceutical Biotechnology
   (PANPB2563), Faculty of Pharmaceutical Sciences, Khon Kaen University,
   Thailand.
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NR 28
TC 3
Z9 3
U1 1
U2 14
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0102-695X
EI 1981-528X
J9 REV BRAS FARMACOGN
JI Rev. Bras. Farmacogn.-Braz. J. Pharmacogn.
PD AUG
PY 2022
VL 32
IS 4
BP 555
EP 562
DI 10.1007/s43450-022-00275-5
EA JUL 2022
PG 8
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 3W6IP
UT WOS:000819899300001
DA 2025-06-11
ER

PT J
AU van den Brink, W
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   Wopereis, S
AF van den Brink, Willem
   van Bilsen, Jolanda
   Salic, Kanita
   Hoevenaars, Femke P. M.
   Verschuren, Lars
   Kleemann, Robert
   Bouwman, Jildau
   Ronnett, Gabriele, V
   Ommen, Ben van
   Wopereis, Suzan
TI Current and Future Nutritional Strategies to Modulate Inflammatory
   Dynamics in Metabolic Disorders
SO FRONTIERS IN NUTRITION
LA English
DT Review
DE chronic low-grade inflammation; lifestyle; metabolism; phenotypic
   flexibility; resilience; nutrition
ID LOW-GRADE INFLAMMATION; ADIPOSE-TISSUE INFLAMMATION; FATTY-ACIDS; GUT
   MICROBIOTA; MEDIATED INFLAMMATION; LIVER INFLAMMATION; OXIDATIVE STRESS;
   HEALTHY-SUBJECTS; DOSE-RESPONSE; IMMUNE CELLS
AB Obesity, type 2 diabetes, and other metabolic disorders have a large impact on global health, especially in Western countries. An important hallmark of metabolic disorders is chronic low-grade inflammation. A key player in chronic low-grade inflammation is dysmetabolism, which is defined as the inability to keep homeostasis resulting in loss of lipid control, oxidative stress, inflammation, and insulin resistance. Although often not yet detectable in the circulation, chronic low-grade inflammation can be present in one or multiple organs. The response to a metabolic challenge containing lipids may magnify dysfunctionalities at the tissue level, causing an overflow of inflammatory markers into the circulation and hence allow detection of early low-grade inflammation. Here, we summarize the evidence of successful application of metabolic challenge tests in type 2 diabetes, metabolic syndrome, obesity, and unhealthy aging. We also review how metabolic challenge tests have been successfully applied to evaluate nutritional intervention effects, including an "anti-inflammatory" mixture, dark chocolate, whole grain wheat and overfeeding. Additionally, we elaborate on future strategies to (re)gain inflammatory flexibility. Through epigenetic and metabolic regulation, the inflammatory response may be trained by regular mild and metabolic triggers, which can be understood from the perspective of trained immunity, hormesis and pro-resolution. New strategies to optimize dynamics of inflammation may become available.
C1 [van den Brink, Willem; Hoevenaars, Femke P. M.; Verschuren, Lars; Bouwman, Jildau; Ommen, Ben van; Wopereis, Suzan] Netherlands Org Appl Sci Res TNO, Dept Microbiol & Syst Biol, Zeist, Netherlands.
   [van Bilsen, Jolanda] Netherlands Org Appl Sci Res TNO, Dept Risk Anal Prod Dev, Zeist, Netherlands.
   [Salic, Kanita; Kleemann, Robert] Netherlands Org Appl Sci Res TNO, Dept Metab Hlth Res, Leiden, Netherlands.
   [Ronnett, Gabriele, V] Janssen Res & Dev 11C, Spring House, PA USA.
C3 Netherlands Organization Applied Science Research; Netherlands
   Organization Applied Science Research
RP Wopereis, S (corresponding author), Netherlands Org Appl Sci Res TNO, Dept Microbiol & Syst Biol, Zeist, Netherlands.
EM suzan.wopensis@tno.nl
OI Hoevenaars, Femke Petronella Maria/0000-0002-1207-925X; van Bilsen,
   Jolanda/0000-0003-3439-5445
FU Johnson & Johnson Family of Consumer Companies
FX The work was sponsored by Johnson & Johnson Family of Consumer
   Companies. The sponsor had no input on the design, data, or conclusions
   of the study.
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NR 116
TC 47
Z9 50
U1 0
U2 22
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD AUG 26
PY 2019
VL 6
AR 129
DI 10.3389/fnut.2019.00129
PG 14
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA IT1SQ
UT WOS:000482627400001
PM 31508422
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Varadharaj, S
   Kelly, OJ
   Khayat, RN
   Kumar, PS
   Ahmed, N
   Zweier, JL
AF Varadharaj, Saradhadevi
   Kelly, Owen J.
   Khayat, Rami N.
   Kumar, Purnima S.
   Ahmed, Naseer
   Zweier, Jay L.
TI Role of Dietary Antioxidants in the Preservation of vascular Function
   and the Modulation of Health and Disease
SO FRONTIERS IN CARDIOVASCULAR MEDICINE
LA English
DT Review
DE antioxidants; endothelial nitric oxide synthase coupling; nitric oxide;
   blood flow; vascular health
ID NITRIC-OXIDE SYNTHASE; IMPROVES ENDOTHELIAL FUNCTION; GREEN TEA
   CONSUMPTION; COCOA FLAVANOL INTAKE; CARDIOVASCULAR-DISEASE; OXIDATIVE
   STRESS; PROTEIN GLUTATHIONYLATION; METABOLIC SYNDROME; PROGENITOR CELLS;
   GENE-EXPRESSION
AB In vascular diseases, including hypertension and atherosclerosis, vascular endothelial dysfunction (VED) occurs secondary to altered function of endothelial nitric oxide synthase (eNOS). A novel redox regulated pathway was identified through which eNOS is uncoupled due to S-glutathionylation of critical cysteine residues, resulting in superoxide free radical formation instead of the vasodilator molecule, nitric oxide. In addition, the redox sensitive cofactor tetrahydrobiopterin, BH4, is also essential for eNOS coupling. Antioxidants, either individually or combined, can modulate eNOS uncoupling by scavenging free radicals or impairing specific radical generating pathways, thus preventing oxidative stress and ameliorating VED. Epidemiological evidence and dietary guidelines suggest that diets high in antioxidants, or antioxidant supplementation, could preserve vascular health and prevent cardiovascular diseases (CVDs). Therefore, the purpose of this review is to highlight the possible role of dietary antioxidants in regulating eNOS function and uncoupling which is critical for maintenance of vascular health with normal blood flow/circulation and prevention of VED. We hypothesize that a conditioned dietary approach with suitable antioxidants may limit systemic oxidation, maintain a beneficial ratio of reduced to oxidized glutathione, and other redox markers, and minimize eNOS uncoupling serving to prevent CVD and possibly other chronic diseases.
C1 [Varadharaj, Saradhadevi; Kelly, Owen J.] Abbott Nutr, Columbus, OH 43229 USA.
   [Varadharaj, Saradhadevi; Zweier, Jay L.] Ohio State Univ, Div Cardiovasc Med, Dept Internal Med, Coll Med,Davis Heart & Lung Res Inst, Columbus, OH 43210 USA.
   [Khayat, Rami N.] Div Pulm Crit Care & Sleep, Sleep Heart Program, Columbus, OH USA.
   [Kumar, Purnima S.] Ohio State Univ, Coll Dent, Columbus, OH 43210 USA.
   [Ahmed, Naseer] Abbott Labs, Chicago, IL USA.
C3 University System of Ohio; Ohio State University; University System of
   Ohio; Ohio State University; Abbott Laboratories
RP Varadharaj, S (corresponding author), Abbott Nutr, Columbus, OH 43229 USA.; Varadharaj, S (corresponding author), Ohio State Univ, Div Cardiovasc Med, Dept Internal Med, Coll Med,Davis Heart & Lung Res Inst, Columbus, OH 43210 USA.
EM saradhadevi.varadharaj@abbott.com
RI Khayat, Rami/E-3380-2011; Kelly, Owen/HLQ-2548-2023; Kumar,
   Purnima/F-6363-2013
OI Kelly, Owen/0000-0001-5137-7316; Kumar, Purnima/0000-0001-5844-1341
FU National Institute of Health [HL 131941, HL 135648, EB0169096]
FX Abbott Nutrition did not provide funding to authors for the research
   work. Abbott Nutrition provided publication costs. Cellular and
   molecular work was supported by National Institute of Health R01 grants
   HL 131941, HL 135648, EB0169096 (JZ). The authors would like to
   acknowledge Dr. Sara Cole and Brian Kemmenoe, Campus Microscopy &
   Imaging Core facility, The Ohio State University, for allowing access to
   acquire immunofluorescence image for the cover page.
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NR 121
TC 72
Z9 75
U1 0
U2 8
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2297-055X
J9 FRONT CARDIOVASC MED
JI Front. Cardiovasc. Med.
PD NOV 1
PY 2017
VL 4
AR 64
DI 10.3389/fcvm.2017.00064
PG 11
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA FX5LS
UT WOS:000426121200001
PM 29164133
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Pintana, H
   Sripetchwandee, J
   Supakul, L
   Apaijai, N
   Chattipakorn, N
   Chattipakorn, S
AF Pintana, Hiranya
   Sripetchwandee, Jirapas
   Supakul, Luerat
   Apaijai, Nattayaporn
   Chattipakorn, Nipon
   Chattipakorn, Siriporn
TI Garlic extract attenuates brain mitochondrial dysfunction and cognitive
   deficit in obese-insulin resistant rats
SO APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
LA English
DT Article
DE brain; learning and memory; antioxidant; high-fat diet; metabolic
   syndrome
ID HIGH-FAT DIET; OXIDATIVE STRESS; ALLIUM-SATIVUM; SYNAPTIC PLASTICITY;
   LIPID-PEROXIDATION; CEREBRAL-ISCHEMIA; MEMORY IMPAIRMENT; RECEPTOR
   FUNCTION; SKELETAL-MUSCLE; S-ALLYLCYSTEINE
AB Oxidative stress in the obese-insulin resistant condition has been shown to affect cognitive as well as brain mitochondrial functions. Garlic extract has exerted a potent antioxidant effect. However, the effects of garlic extract on the brain of obese-insulin resistant rats have never been investigated. We hypothesized that garlic extract improves cognitive function and brain mitochondrial function in obese-insulin resistant rats induced by long-term high-fat diet (HFD) consumption. Male Wistar rats were fed either normal diet or HFD for 16 weeks (n = 24/group). At week 12, rats in each dietary group received either vehicle or garlic extract (250 and 500 mg.kg(-1).day(-1)) for 28 days. Learning and memory behaviors, metabolic parameters, and brain mitochondrial function were determined at the end of treatment. HFD led to increased body weight, visceral fat, plasma insulin, cholesterol, and malondialdehyde (MDA) levels, indicating the development of insulin resistance. Furthermore, HFD rats had cognitive deficit and brain mitochondrial dysfunction. HFD rats treated with both doses of garlic extract had decreased body weight, visceral fat, plasma cholesterol, and MDA levels. Garlic extract also improved cognitive function and brain mitochondrial function, which were impaired in obese-insulin resistant rats caused by HFD consumption.
C1 [Pintana, Hiranya; Sripetchwandee, Jirapas; Supakul, Luerat; Apaijai, Nattayaporn; Chattipakorn, Nipon; Chattipakorn, Siriporn] Chiang Mai Univ, Neurophysiol Unit, Cardiac Electrophysiol Res & Training Ctr, Fac Med, Chiang Mai 50000, Thailand.
   [Chattipakorn, Siriporn] Chiang Mai Univ, Fac Dent, Dept Oral Biol & Diagnost Sci, Chiang Mai 50000, Thailand.
C3 Chiang Mai University; Chiang Mai University
RP Chattipakorn, S (corresponding author), Chiang Mai Univ, Neurophysiol Unit, Cardiac Electrophysiol Res & Training Ctr, Fac Med, Chiang Mai 50000, Thailand.
EM siriporn.c@cmu.ac.th
RI Chattipakorn, Nipon/AAJ-4049-2021
OI Chattipakorn, Siriporn/0000-0003-1677-7052; Chattipakorn,
   Nipon/0000-0003-3026-718X; Sripetchwandee, Jirapas/0000-0002-4473-7018
FU Thailand Research Fund [TRF-BRG5780016, TRF-RTA5580006]; Faculty of
   Medicine Chiang Mai University Endowment Fund; National Research Council
   of Thailand; Thailand Research Fund through the Royal Golden Jubilee
   Program [PHD/0248/2552, PHD/0025/2555]; Chiang Mai University Excellent
   Center Award
FX This work was supported by grants from the Thailand Research Fund
   TRF-BRG5780016 (S. C.), TRF-RTA5580006 (N.C.), Faculty of Medicine
   Chiang Mai University Endowment Fund (N. C.), National Research Council
   of Thailand (S. C.), Thailand Research Fund through the Royal Golden
   Jubilee Program (PHD/0248/2552: J. S. and S. C.; PHD/0025/2555: H. P.
   and S.C.), and Chiang Mai University Excellent Center Award (N.C.).
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NR 64
TC 28
Z9 29
U1 0
U2 12
PU CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS
PI OTTAWA
PA 65 AURIGA DR, SUITE 203, OTTAWA, ON K2E 7W6, CANADA
SN 1715-5312
EI 1715-5320
J9 APPL PHYSIOL NUTR ME
JI Appl. Physiol. Nutr. Metab.
PD DEC
PY 2014
VL 39
IS 12
BP 1373
EP 1379
DI 10.1139/apnm-2014-0255
PG 7
WC Nutrition & Dietetics; Physiology; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics; Physiology; Sport Sciences
GA AS9FJ
UT WOS:000344548200008
PM 25350296
DA 2025-06-11
ER

PT J
AU Park, J
   Middlekauff, HR
   Campese, VM
AF Park, Jeanie
   Middlekauff, Holly R.
   Campese, Vito M.
TI Abnormal Sympathetic Reactivity to the Cold Pressor Test in Overweight
   Humans
SO AMERICAN JOURNAL OF HYPERTENSION
LA English
DT Article
DE blood pressure; hypertension; overweight; physiological stress response;
   sympathetic nervous system
ID FUTURE BLOOD-PRESSURE; BODY-FAT DISTRIBUTION; HUMAN MUSCLE NERVES;
   CARDIOVASCULAR REACTIVITY; NORADRENALINE SPILLOVER; GENDER-DIFFERENCES;
   METABOLIC SYNDROME; NEURAL ACTIVATION; HEART-FAILURE; OBESITY
AB BACKGROUND
   Overweight individuals (body mass index (BMI) 25-29.9 kg/m(2)) are at higher risk for developing cardiovascular disease and hypertension when compared with lean individuals of normal weight (BMI 18.5-24.9 kg/m(2)). The purpose of this study was to test the hypothesis that exaggerated sympathetic nervous system responses to stressors may be one potential mechanism that predisposes overweight individuals to developing hypertension.
   METHODS
   We compared heart rate (HR), blood pressure (BP), and muscle sympathetic nerve activity (MSNA) using microneurography, in normotensive overweight individuals compared with age-matched lean controls, at baseline and during two sympathoexcitatory maneuvers: cold pressor test (CPT), and static handgrip exercise (SHG 30%).
   RESULTS
   During CPT, MSNA increased in both groups, but the magnitude of MSNA response was significantly greater (P = 0.03) in overweight (+18.1 +/- 2.8 bursts/min) compared with lean controls (+10.8 +/- 1.2 bursts/min). MSNA response to SHG at 30% maximum voluntary contraction (MVC) was similar between the two groups. There were no significant differences in systolic (SBP) or diastolic BP (DBP) responses or HR responses between the two groups during either maneuver.
   CONCLUSIONS
   Normotensive overweight individuals have an exaggerated MSNA response to the CPT. Augmented sympathetic reactivity to cold stress may contribute to increased risk of hypertension in overweight individuals.
C1 [Park, Jeanie] Emory Univ, Sch Med, Dept Med, Div Renal, Atlanta, GA 30322 USA.
   [Park, Jeanie] Atlanta VA Med Ctr, Res Serv, Decatur, GA USA.
   [Middlekauff, Holly R.] Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Div Cardiol, Los Angeles, CA 90095 USA.
   [Campese, Vito M.] USC Keck Sch Med, Dept Med, Div Nephrol, Los Angeles, CA USA.
C3 Emory University; US Department of Veterans Affairs; Veterans Health
   Administration (VHA); Atlanta VA Medical Center; Atlanta VA Health Care
   System; University of California System; University of California Los
   Angeles; University of California Los Angeles Medical Center; David
   Geffen School of Medicine at UCLA; University of Southern California
RP Park, J (corresponding author), Emory Univ, Sch Med, Dept Med, Div Renal, Atlanta, GA 30322 USA.
EM jeanie.park@emory.edu
OI Park, Jeanie/0000-0002-5799-9172
FU National Institutes of Health [K23HL098744]; Amgen Nephrology Junior
   Faculty Award; Atlanta Research and Education Foundation
FX J.P. is supported by National Institutes of Health grant K23HL098744,
   Amgen Nephrology Junior Faculty Award, and the Atlanta Research and
   Education Foundation.
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NR 39
TC 37
Z9 41
U1 0
U2 15
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 0895-7061
J9 AM J HYPERTENS
JI Am. J. Hypertens.
PD DEC
PY 2012
VL 25
IS 12
BP 1236
EP 1241
DI 10.1038/ajh.2012.115
PG 6
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 038LD
UT WOS:000311175300002
PM 22895452
OA Green Published
DA 2025-06-11
ER

PT J
AU Bacchetti, T
   Morresi, C
   Simonetti, O
   Ferretti, G
AF Bacchetti, Tiziana
   Morresi, Camilla
   Simonetti, Oriana
   Ferretti, Gianna
TI Effect of Diet on HDL in Obesity
SO MOLECULES
LA English
DT Review
DE adipose tissue; dietary antioxidants; inflammation; lipoproteins;
   obesity; oxidative stress
ID HIGH-DENSITY-LIPOPROTEINS; REVERSE CHOLESTEROL TRANSPORT; ADIPOSE-TISSUE
   DYSFUNCTION; ESTER TRANSFER PROTEIN; APOLIPOPROTEIN-A-I;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; HEPATIC LIPASE; PARAOXONASE-1
   ACTIVITY; OVERWEIGHT PATIENTS
AB Alterations of plasma lipoprotein levels and oxidative stress are frequently observed in obese patients, including low high-density lipoprotein (HDL) cholesterol (HDL-C) levels and alterations of HDL composition. Dysfunctional HDL with lower antioxidant and anti-inflammatory properties have also been demonstrated in obesity. There is increasing evidence that white adipose tissue (WAT) participates in several metabolic activities and modulates HDL-C levels and function. In obese subjects, the changes in morphology and function of adipose tissue lead to impaired regulatory function and are associated with a state of low-grade chronic inflammation, with increased release of pro-inflammatory adipokines and cytokines. These alterations may affect HDL metabolism and functions; thus, adipose tissue is considered a potential target for the prevention and treatment of obesity. A cornerstone of obesity prevention and therapy is lifestyle modification through dietary changes, which is reflected in the modulation of plasma lipoprotein metabolism. Some dietary components and metabolites directly affect the composition and structure of HDL and modulate its anti-inflammatory and vasoprotective properties. The aims of the review are to summarize the crosstalk between adipocytes and HDL dysfunction in human obesity and to highlight recent discoveries on beneficial dietary patterns as well as nutritional components on inflammation and HDL function in human obesity.
C1 [Bacchetti, Tiziana; Morresi, Camilla] Polytech Univ Marche, Dept Life & Environm Sci, I-60131 Ancona, Italy.
   [Simonetti, Oriana] Polytech Univ Marche, Dept Clin & Mol Sci, Clin Dermatol, I-60126 Ancona, Italy.
   [Ferretti, Gianna] Polytech Univ Marche, Res Ctr Hlth Educ & Hlth Promot, Dept Clin Expt Sci & Odontostomatol, I-60126 Ancona, Italy.
   [Ferretti, Gianna] Polytech Univ Marche, Res Ctr Obes, I-60126 Ancona, Italy.
C3 Marche Polytechnic University; Marche Polytechnic University; Marche
   Polytechnic University; Marche Polytechnic University
RP Bacchetti, T; Morresi, C (corresponding author), Polytech Univ Marche, Dept Life & Environm Sci, I-60131 Ancona, Italy.
EM t.bacchetti@univpm.it; c.morresi@univpm.it; o.simonetti@univpm.it;
   g.ferretti@univpm.it
RI Simonetti, Oriana/CAF-8338-2022; MORRESI, CAMILLA/LTC-8394-2024
OI Bacchetti, Tiziana/0000-0003-3346-9588; MORRESI,
   CAMILLA/0000-0002-9740-3556
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NR 139
TC 1
Z9 1
U1 5
U2 5
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 1420-3049
J9 MOLECULES
JI Molecules
PD DEC
PY 2024
VL 29
IS 24
AR 5955
DI 10.3390/molecules29245955
PG 17
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA Q4S2O
UT WOS:001384592000001
PM 39770044
OA gold
DA 2025-06-11
ER

PT J
AU Hajmrle, C
   Smith, N
   Spigelman, AF
   Dai, XQ
   Senior, L
   Bautista, A
   Ferdaoussi, M
   MacDonald, PE
AF Hajmrle, Catherine
   Smith, Nancy
   Spigelman, Aliya F.
   Dai, Xiaoqing
   Senior, Laura
   Bautista, Austin
   Ferdaoussi, Mourad
   MacDonald, Patrick E.
TI Interleukin-1 signaling contributes to acute islet compensation
SO JCI INSIGHT
LA English
DT Article
ID HUMAN PANCREATIC-ISLETS; STIMULATED INSULIN-SECRETION; BETA-CELL
   PROLIFERATION; FOCAL ADHESION KINASE; ISOLATED RAT ISLETS; SHORT-TERM
   EXPOSURE; RECEPTOR ANTAGONIST; METABOLIC SYNDROME; DOUBLE-BLIND; GLUCOSE
AB IL-1 beta is a well-established inducer of both insulin resistance and impaired pancreatic islet function. Despite this, findings examining IL-1 receptor deficiency or antagonism in in vivo animal models, as well as in clinical studies of type 2 diabetic (T2D) patients, have led to conflicting results, suggesting that the actions of IL-1 beta on glycemic control may be pleiotropic in nature. In the present work, we find that the ability of IL-1 beta to amplify glucose-stimulated insulin secretion from human islets correlates with donor BMI. Islets from obese donors are sensitized to the insulinotropic effects of this cytokine, whereas the stimulatory effects of IL-1 beta are lost in islets from obese T2D patients, suggesting a role for IL-1 signaling in islet compensation. Indeed, mice deficient in IL-1 receptor type I become glucose intolerant more rapidly than their WT littermates and have impaired secretory responses during the acute stages of inflammatory and metabolic stress induced by LPS and high-fat diet, respectively. IL-1 beta directly enhances beta cell insulin secretion by increasing granule docking and soluble N-ethylmaleimide-sensitive factor attachment receptor (SNARE) complex formation at the plasma membrane. Together, our study highlights the importance of IL-1 beta signaling in islet compensation to metabolic and inflammatory stress.
C1 Univ Alberta, Dept Pharmacol, Edmonton, AB, Canada.
   Univ Alberta, Alberta Diabet Inst, Edmonton, AB, Canada.
C3 University of Alberta; University of Alberta
RP MacDonald, PE (corresponding author), Univ Alberta, Li Ka Shing Ctr, Rm 6-126, Edmonton, AB T6G 2E1, Canada.
EM pmacdonald@ualberta.ca
RI MacDonald, Patrick/A-4154-2008; Ferdaoussi, Mourad/AGN-8892-2022
OI Spigelman, Aliya F/0000-0001-6188-2041; MacDonald,
   Patrick/0000-0002-5439-6288
FU Canadian Institutes of Health Research Funding Source: Medline
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NR 66
TC 66
Z9 71
U1 1
U2 4
PU AMER SOC CLINICAL INVESTIGATION INC
PI ANN ARBOR
PA 2015 MANCHESTER RD, ANN ARBOR, MI 48104 USA
SN 2379-3708
J9 JCI INSIGHT
JI JCI Insight
PD APR 7
PY 2016
VL 1
IS 4
AR e86055
DI 10.1172/jci.insight.86055
PG 14
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA EB1IU
UT WOS:000387104400004
PM 27699257
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Ruiz-Romero, GA
   Alvarez-Delgado, C
AF Ruiz-Romero, Geovanni Alberto
   Alvarez-Delgado, Carolina
TI Effects of estrogens in mitochondria: An approach to type 2 diabetes
SO AIMS MOLECULAR SCIENCE
LA English
DT Article
DE type 2 diabetes; mitochondria; estrogen; estrogen receptor; insulin
   resistance; mitochondrial dysfunction
ID PANCREATIC BETA-CELLS; MEMBRANE MAM INTEGRITY; INSULIN-RESISTANCE;
   SKELETAL-MUSCLE; ENDOPLASMIC-RETICULUM; RECEPTOR-ALPHA; OXIDATIVE
   STRESS; ADIPOSE-TISSUE; SUBCELLULAR-DISTRIBUTION; METABOLIC SYNDROME
AB Type 2 diabetes (T2D) is characterized by a state of hyperglycemia in the blood due to insulin resistance developed by organs such as muscle, liver, and adipose tissue. A common factor in individuals with T2D is mitochondrial dysfunction. Mitochondria are dynamic organelles responsible for energy and antioxidant metabolism in the cells. Estrogens, such as 17 beta-estradiol (E2), are steroid hormones that have shown a great capacity to regulate mitochondrial function and dynamics through estrogen receptors (ERs), modulating the expression of mitochondrial biogenesis-related genes and cell signaling mechanisms. The accumulation of reactive oxygen species, the low capacity for ATP synthesis, and morphological alterations are some of the mitochondrial processes impaired in T2D. Insulin signaling and secretion by pancreatic beta-cells, ATP-dependent processes, are also altered in T2D. In this review, mitochondria were exposed as the central axis for the action of estrogens in individuals with T2D. Estrogens increased glucose uptake, insulin signaling, and mitochondrial bioenergetics, and decreased ectopic lipid accumulation in non-adipose tissues and oxidative stress, among other processes, in various preclinical and clinical models of diabetes. The development of strategies to target compounds to mitochondria could represent a novel therapeutic alternative to potentiate the effects of estrogens on this organelle in patients with insulin resistance and T2D.
C1 [Ruiz-Romero, Geovanni Alberto; Alvarez-Delgado, Carolina] Ctr Invest Cient & Educ Super Ensenada, Dept Innovac Biomed, Ensenada, Baja California, Mexico.
C3 CICESE - Centro de Investigacion Cientifica y de Educacion Superior de
   Ensenada
RP Alvarez-Delgado, C (corresponding author), Ctr Invest Cient & Educ Super Ensenada, Dept Innovac Biomed, Ensenada, Baja California, Mexico.
EM alvarezc@cicese.mx
RI Álvarez-Delgado, Carolina/B-8195-2015
OI Ruiz-Romero, Geovanni Alberto/0009-0007-9726-2339
FU CONAHCyT-CVU; CICESE [642857, CF-6391-2019]; CONAHCyT [642857]; 
   [685-110]
FX Geovanni Alberto Ruiz-Romero has a scholarship from CONAHCyT-CVU 642857
   and is a graduate student in Life Sciences at CICESE. This work was made
   possible by economic support from grants 685-110 from CICESE and
   "Ciencia de Frontera" CF-6391-2019 from CONAHCyT.
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NR 166
TC 2
Z9 2
U1 1
U2 2
PU AMER INST MATHEMATICAL SCIENCES-AIMS
PI SPRINGFIELD
PA PO BOX 2604, SPRINGFIELD, MO 65801-2604, UNITED STATES
SN 2372-0301
J9 AIMS MOL SCI
JI AIMS Mol. Sci.
PY 2024
VL 11
IS 1
BP 72
EP 98
DI 10.3934/molsci.2024006
PG 27
WC Biochemistry & Molecular Biology
WE Emerging Sources Citation Index (ESCI)
SC Biochemistry & Molecular Biology
GA IT5T2
UT WOS:001168605500001
OA gold
DA 2025-06-11
ER

PT J
AU Pu, SQ
   Wu, XJ
   Yang, XY
   Zhang, YZ
   Dai, YK
   Zhang, YL
   Wu, XT
   Liu, Y
   Cui, XN
   Jin, HY
   Cao, JH
   Li, RL
   Cai, JZ
   Cao, Q
   Hu, L
   Gao, Y
AF Pu, Shuqi
   Wu, Xiaojie
   Yang, Xiaoying
   Zhang, Yunzhan
   Dai, Yunkai
   Zhang, Yueling
   Wu, Xiaoting
   Liu, Yan
   Cui, Xiaona
   Jin, Haiyong
   Cao, Jianhong
   Li, Ruliu
   Cai, Jiazhong
   Cao, Qizhi
   Hu, Ling
   Gao, Yong
TI The Therapeutic Role of Xenobiotic Nuclear Receptors Against Metabolic
   Syndrome
SO CURRENT DRUG METABOLISM
LA English
DT Review
DE Xenobiotic Nuclear Receptors (XNRs); Peroxisome Proliferator-Activated
   Receptor (PPAR); Farnesoid X Receptor (FXR); Liver X Receptor (LXR);
   Pregnane X Receptor (PXR); Constitutive Androstane Receptor (CAR);
   diabetes
ID FARNESOID-X-RECEPTOR; BILE-ACID SYNTHESIS; ENDOPLASMIC-RETICULUM STRESS;
   PEROXISOME-PROLIFERATOR; PPAR-GAMMA; INSULIN-RESISTANCE; ADIPOSE-TISSUE;
   MYOCARDIAL-INFARCTION; GLUCOSE-METABOLISM; OXIDATIVE STRESS
AB Background: Diabetes, with an increased prevalence and various progressive complications, has become a significant global health challenge. The concrete mechanisms responsible for the development of diabetes still remain incompletely unknown, although substantial researches have been conducted to search for the effective therapeutic targets. This review aims to reveal the novel roles of Xenobiotic Nuclear Receptors (XNRs), including the Peroxisome Proliferator-Activated Receptor (PPAR), the Farnesoid X Receptor (FXR), the Liver X Receptor (LXR), the Pregnane X Receptor (PXR) and the Constitutive Androstane Receptor (CAR), in the development of diabetes and provide potential strategies for research and treatment of metabolic diseases.
   Methods: We retrieved a large number of original data about these five XNRs and organized to focus on their recently discovered functions in diabetes and its complications.
   Results: Increasing evidences have suggested that PPAR, FXR, LXR, PXR and CAR are involved in the development of diabetes and its complications through different mechanisms, including the regulation of glucose and lipid metabolism, insulin and inflammation response and related others.
   Conclusion: PPAR, FXR, LXR, PXR, and CAR, as the receptors for numerous natural or synthetic compounds, may be the most effective therapeutic targets in the treatment of metabolic diseases.
C1 [Pu, Shuqi; Zhang, Yunzhan; Dai, Yunkai; Cao, Jianhong; Li, Ruliu; Cai, Jiazhong; Hu, Ling; Gao, Yong] Guangzhou Univ Chinese Med, PI WEI Inst, Guangzhou, Guangdong, Peoples R China.
   [Wu, Xiaojie; Liu, Yan; Cao, Qizhi] Binzhou Med Univ, Dept Immunol, Yantai, Peoples R China.
   [Yang, Xiaoying] Xuzhou Med Univ, Jiangsu Key Lab Immun & Metab, Dept Pathogen Biol & Immunol, Xuzhou, Jiangsu, Peoples R China.
   [Yang, Xiaoying] Xuzhou Med Univ, Lab Infect & Immun, Xuzhou, Jiangsu, Peoples R China.
   [Zhang, Yueling; Wu, Xiaoting] Binzhou Peoples Hosp, Dept Operating Theatre, Binzhou, Peoples R China.
   [Cui, Xiaona] Xuzhou Med Univ, Jiangsu Key Lab Brain Dis Bioinformat, Res Ctr Biochem & Mol Biol, Xuzhou, Jiangsu, Peoples R China.
   [Jin, Haiyong] Wenzhou Med Univ, Dept Otolaryngol, Affiliated Hosp 2, Wenzhou, Peoples R China.
   [Jin, Haiyong] Wenzhou Med Univ, Yuying Childrens Hosp, Wenzhou, Peoples R China.
C3 Guangzhou University of Chinese Medicine; Binzhou Medical University;
   Xuzhou Medical University; Xuzhou Medical University; Xuzhou Medical
   University; Wenzhou Medical University; Wenzhou Medical University
RP Cao, Q; Hu, L; Gao, Y (corresponding author), Guangzhou Univ Chinese Med, PI WEI Inst, Guangzhou, Guangdong, Peoples R China.
EM gaoyong@gzucm.edu.cn
RI Cao, Jianhong/AFC-6942-2022; Gao, Yong/AAL-4989-2021; hu,
   ling/GWC-1104-2022; Zhang, yueling/HZH-7176-2023
OI Cui, Xiaona/0000-0002-4932-1281
FU National Natural Science Foundation of China [81774238, 81373563];
   Construction of first-class discipline of Guangzhou University of
   Chinese Medicine, Guangzhou University of Chinese Medicine [70];
   Innovation team to foster scientific research projects of Guangzhou
   University of Chinese Medicine, Guangzhou University of Chinese Medicine
   [2016KYTD07]; Xinglin young scholar construction of high levels
   university projects of Guangzhou University of Chinese Medicine,
   Guangzhou [A1-AFD018161Z01129]; youth innovative talents projects of the
   Educational Department of Guangdong Province [A1-AFD018171Z1327]; NSFC
   (National Natural Science Foundation of China) [81703793]; First-class
   discipline construction major project of Guangzhou University of Chinese
   Medicine, Guangzhou University of Chinese Medicine Planning [6]
FX This work was supported by National Natural Science Foundation of China
   (Grants No. 81774238 and 81373563); Construction of first-class
   discipline of Guangzhou University of Chinese Medicine, Guangzhou
   University of Chinese Medicine (2017) No. 70; Innovation team to foster
   scientific research projects of Guangzhou University of Chinese
   Medicine, Guangzhou University of Chinese Medicine (2016) No.
   2016KYTD07; The Xinglin young scholar construction of high levels
   university projects of Guangzhou University of Chinese Medicine,
   Guangzhou (2017), No. A1-AFD018161Z01129; The youth innovative talents
   projects of the Educational Department of Guangdong Province, No.
   A1-AFD018171Z1327; NSFC (National Natural Science Foundation of China),
   No. 81703793. First-class discipline construction major project of
   Guangzhou University of Chinese Medicine, Guangzhou University of
   Chinese Medicine Planning (2018, No. 6).
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NR 117
TC 7
Z9 7
U1 1
U2 18
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1389-2002
EI 1875-5453
J9 CURR DRUG METAB
JI Curr. Drug Metab.
PY 2019
VL 20
IS 1
BP 15
EP 22
DI 10.2174/1389200219666180611083155
PG 8
WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
GA HO2HU
UT WOS:000460735000005
PM 29886826
DA 2025-06-11
ER

PT J
AU Zhang, YM
   Whaley-Connell, AT
   Sowers, JR
   Ren, J
AF Zhang, Yingmei
   Whaley-Connell, Adam T.
   Sowers, James R.
   Ren, Jun
TI Autophagy as an emerging target in cardiorenal metabolic disease: From
   pathophysiology to management
SO PHARMACOLOGY & THERAPEUTICS
LA English
DT Review
DE Cardiorenal metabolic syndrome; Adipose tissue; Liver; Cardiovascular;
   Autophagy
ID DIET-INDUCED OBESITY; DIPEPTIDYL PEPTIDASE-4 INHIBITOR; INDUCED CARDIAC
   CONTRACTILE; SYMPATHETIC-NERVOUS-SYSTEM; ADIPOSE-TISSUE AUTOPHAGY;
   BETA-CELL AUTOPHAGY; INSULIN-RESISTANCE; DIABETIC CARDIOMYOPATHY;
   MOLECULAR-MECHANISMS; LIPID-METABOLISM
AB Although advances in medical technology and health care have improved the early diagnosis and management for cardiorenal metabolic disorders, the prevalence of obesity, insulin resistance, diabetes, hypertension, dyslipidemia, and kidney disease remains high. Findings from numerous population-based studies, clinical trials, and experimental evidence have consolidated a number of theories for the pathogenesis of cardiorenal metabolic anomalies including resistance to the metabolic action of insulin, abnormal glucose and lipid metabolism, oxidative and nitrosative stress, endoplasmic reticulum (ER) stress, apoptosis, mitochondrial damage, and inflammation. Accumulating evidence has recently suggested a pivotal role for proteotoxicity, the unfavorable effects of poor protein quality control, in the pathophysiology of metabolic dysregulation and related cardiovascular complications. The ubiquitin-proteasome system (UPS) and autophagy-lysosomal pathways, two major although distinct cellular clearance machineries, govern protein quality control by degradation and clearance of long-lived or damaged proteins and organelles. Ample evidence has depicted an important role for protein quality control, particularly autophagy, in the maintenance of metabolic homeostasis. To this end, autophagy offers promising targets for novel strategies to prevent and treat cardiorenal metabolic diseases. Targeting autophagy using pharmacological or natural agents exhibits exciting new strategies for the growing problem of cardiorenal metabolic disorders. (C) 2018 Elsevier Inc. All rights reserved.
C1 [Zhang, Yingmei; Ren, Jun] Fudan Univ, Zhongshan Hosp, Dept Cardiol, Shanghai Inst Cardiovasc Dis, Shanghai 200032, Peoples R China.
   [Zhang, Yingmei; Ren, Jun] Univ Wyoming, Coll Hlth Sci, Ctr Cardiovasc Res & Alternat Med, Laramie, WY 82071 USA.
   [Whaley-Connell, Adam T.; Sowers, James R.] Univ Missouri, Harry S Truman Mem Vet Hosp, Sch Med, Res Serv, Columbia, MO USA.
   [Whaley-Connell, Adam T.; Sowers, James R.] Univ Missouri, Sch Med, Dept Med, Diabet & Cardiovasc Ctr, Columbia, MO USA.
C3 Fudan University; University of Wyoming; US Department of Veterans
   Affairs; Veterans Health Administration (VHA); Harry S. Truman Memorial
   Veterans' Hospital; University of Missouri System; University of
   Missouri Columbia; University of Missouri System; University of Missouri
   Columbia
RP Zhang, YM; Ren, J (corresponding author), Fudan Univ, Zhongshan Hosp, Dept Cardiol, Shanghai 200032, Peoples R China.
EM zhang.yingmei@zs-hospital.sh.cn; jren@uwyo.edu
RI Ren, Jun/ACG-5366-2022
OI Ren, Jun/0000-0002-0275-0783
FU American Diabetes Association [7-13-BS-142-BR, NSFC81522004,
   NSFC81570225, NSFC81770261, R01 HL73101-01A, R01 HL107910-01]; US
   veterans Affairs Merit System [0018]
FX This review is dedicated to the late Prof. Gerald M. Reaven, MD, who
   coined the concept of "Syndrome X". The authors received support in part
   from the American Diabetes Association (7-13-BS-142-BR), NSFC81522004,
   NSFC81570225, NSFC81770261, R01 HL73101-01A and R01 HL107910-01 and the
   US veterans Affairs Merit System (0018). The authors wish to greatly
   appreciate the skillful graphical assistance of Ms. Sai Ma from the
   University of Wyoming College of Health Sciences, Laramie, WY 82071 USA
   We wish to express our sincere apology for those authors whose important
   work was unable to be cited due to space limitation.
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NR 331
TC 92
Z9 100
U1 1
U2 39
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0163-7258
EI 1879-016X
J9 PHARMACOL THERAPEUT
JI Pharmacol. Ther.
PD NOV
PY 2018
VL 191
BP 1
EP 22
DI 10.1016/j.pharmthera.2018.06.004
PG 22
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Pharmacology & Pharmacy
GA GZ2TY
UT WOS:000449242500001
PM 29909238
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Hernandez-Camacho, JD
   Bernier, M
   López-Lluch, G
   Navas, P
AF Hernandez-Camacho, Juan D.
   Bernier, Michel
   Lopez-Lluch, Guillermo
   Navas, Placido
TI Coenzyme Q10 Supplementation in Aging and Disease
SO FRONTIERS IN PHYSIOLOGY
LA English
DT Review
DE Coenzyme Q; aging; disease; mitochondria; antioxidant; CoQ deficiency
ID RESISTANT NEPHROTIC SYNDROME; ACTIVATED RECEPTOR-ALPHA; Q BIOSYNTHESIS;
   DOUBLE-BLIND; MITOCHONDRIAL DYSFUNCTION; REDUCED FORM; INFLAMMATORY
   MARKERS; PARKINSONS-DISEASE; OXIDATIVE STRESS; HEART-FAILURE
AB Coenzyme Q (CoQ) is an essential component of the mitochondrial electron transport chain and an antioxidant in plasma membranes and lipoproteins. It is endogenously produced in all cells by a highly regulated pathway that involves a mitochondrial multiprotein complex. Defects in either the structural and/or regulatory components of CoQ complex or in non-CoQ biosynthetic mitochondrial proteins can result in a decrease in CoQ concentration and/or an increase in oxidative stress. Besides CoQ(10) deficiency syndrome and aging, there are chronic diseases in which lower levels of CoQ(10) are detected in tissues and organs providing the hypothesis that CoQ(10) supplementation could alleviate aging symptoms and/or retard the onset of these diseases. Here, we review the current knowledge of CoQ(10) biosynthesis and primary CoQ(10) deficiency syndrome, and have collected published results from clinical trials based on CoQ(10) supplementation. There is evidence that supplementation positively affects mitochondrial deficiency syndrome and the symptoms of aging based mainly on improvements in bioenergetics. Cardiovascular disease and inflammation are alleviated by the antioxidant effect of CoQ(10). There is a need for further studies and clinical trials involving a greater number of participants undergoing longer treatments in order to assess the benefits of CoQ(10) treatment in metabolic syndrome and diabetes, neurodegenerative disorders, kidney diseases, and human fertility.
C1 [Hernandez-Camacho, Juan D.; Lopez-Lluch, Guillermo; Navas, Placido] Univ Pablo Olavide, CSIC JA, Ctr Andaluz Biol Desarrollo, Seville, Spain.
   [Hernandez-Camacho, Juan D.; Lopez-Lluch, Guillermo; Navas, Placido] Univ Pablo Olavide, CSIC JA, Inst Salud Carlos 3, CIBERER, Seville, Spain.
   [Bernier, Michel] NIA, Translat Gerontol Branch, NIH, Baltimore, MD 21224 USA.
C3 Consejo Superior de Investigaciones Cientificas (CSIC); Universidad
   Pablo de Olavide; CSIC - Andalusian Center for Developmental Biology
   (CABD); CIBER - Centro de Investigacion Biomedica en Red; CIBERER;
   Universidad Pablo de Olavide; National Institutes of Health (NIH) - USA;
   NIH National Institute on Aging (NIA)
RP Navas, P (corresponding author), Univ Pablo Olavide, CSIC JA, Ctr Andaluz Biol Desarrollo, Seville, Spain.; Navas, P (corresponding author), Univ Pablo Olavide, CSIC JA, Inst Salud Carlos 3, CIBERER, Seville, Spain.
EM pnavas@upo.es
RI Bernier, Michel/Y-7139-2019; NAVAS, PLACIDO/R-5943-2019; Lopez-Lluch,
   Guillermo/N-4742-2014
OI Bernier, Michel/0000-0002-5948-368X; Lopez-Lluch,
   Guillermo/0000-0001-9830-8502
FU Spanish Ministry of Health, Instituto de Salud Carlos III (ISCIII) [FIS
   PI14-01962]; Andalusian Government [BIO177]; CIBERER, Instituto de Salud
   Carlos III; National Institute on Aging, NIH
FX This work has been partially funded by the Spanish Ministry of Health,
   Instituto de Salud Carlos III (ISCIII), FIS PI14-01962, and the
   Andalusian Government grant BIO177 (FEDER funds of European Commission).
   JH-C has been awarded by CIBERER, Instituto de Salud Carlos III. This
   work was also supported, in part, by the Intramural Research Program of
   the National Institute on Aging, NIH.
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NR 126
TC 237
Z9 257
U1 4
U2 85
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1664-042X
J9 FRONT PHYSIOL
JI Front. Physiol.
PD FEB 5
PY 2018
VL 9
AR 44
DI 10.3389/fphys.2018.00044
PG 11
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA FU8YK
UT WOS:000424142300002
PM 29459830
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Ibitoye, OB
   Ghali, UM
   Adekunle, JB
   Uwazie, JN
   Ajiboye, TO
AF Ibitoye, O. B.
   Ghali, U. M.
   Adekunle, J. B.
   Uwazie, J. N.
   Ajiboye, T. O.
TI Antidyslipidemic, Anti-Inflammatory, and Antioxidant Activities of
   Aqueous Leaf Extract of Dioscoreophyllum cumminsii (Stapf) Diels
   in High-Fat Diet-Fed Rats
SO EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Article
ID INDUCED METABOLIC SYNDROME; OXIDATIVE STRESS; INSULIN-RESISTANCE;
   INDUCED DYSLIPIDEMIA; LIPID-PEROXIDATION; INDUCED OBESITY;
   ADIPOSE-TISSUE; INFLAMMATION; LIVER; ACID
AB Dioscoreophyllum cumminsii (Stapf) Diels leaves are widely used in the treatment of diabetes, obesity, and cardiovascular related complications in Nigeria. This study investigates the anti-inflammatory and antiobesity effect of aqueous extract of Dioscoreophyllum cumminsii leaves in high-fat diet-(HFD-) induced obese rats. HFD-fed rats were given 100, 200, and 400mgkg(-1) body weight of aqueous extract of Dioscoreophyllum cumminsii leaves for 4 weeks starting from 9th week of HFD treatment. D. cumminsii leaves aqueous extract reversed HFD-mediated decrease in the activities of superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, and glucose 6-phosphate dehydrogenase. Moreover, HFD-mediated elevation in the levels of conjugated dienes, lipid hydroperoxides, malondialdehyde, protein carbonyl, and DNA fragmentation in rats liver was lowered. HFD-mediated alterations in serum total cholesterol, triacylglycerol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and very low-density lipoprotein cholesterol were significantly reversed by the extract. The treatment of HFD-fed rats reduced the levels of insulin, leptin, protein carbonyl, fragmented DNA, and tumour necrosis factor-alpha and interleukin- (IL-) 6 and IL- 8 and increased the adiponectin level. This study showed that aqueous extract of Dioscoreophyllum cumminsii leaves has potential antiobesity and anti-inflammatory effects through modulation of obesity-induced inflammation, oxidative stress, and obesity-related disorder in HFD-induced obese rats.
C1 [Ibitoye, O. B.; Ghali, U. M.; Adekunle, J. B.] Al Hikmah Univ, Dept Biol Sci, Antioxidants Redox Biol & Toxicol Res Lab, Ilorin, Nigeria.
   [Uwazie, J. N.] Univ Ilorin, Dept Biochem, Ilorin, Nigeria.
   [Ajiboye, T. O.] Nile Univ Nigeria, Dept Med Biochem, Coll Hlth Sci, Antioxidants Redox Biol & Toxicol Res Grp, Fed Capital Terr, Nigeria.
C3 University of Ilorin
RP Ajiboye, TO (corresponding author), Nile Univ Nigeria, Dept Med Biochem, Coll Hlth Sci, Antioxidants Redox Biol & Toxicol Res Grp, Fed Capital Terr, Nigeria.
EM ajiboyeyong@yahoo.com
RI Uwazie, Judith/ABC-3142-2020; GHALI, UMAR/ABI-5679-2020; Ajiboye,
   Taofeek/H-5383-2011; Ohanaka Nkechinyere, Judith/ACG-7706-2022
OI GHALI, UMAR MUHAMMAD/0000-0002-3500-8075; Ohanaka Nkechinyere,
   Judith/0000-0002-1936-2306
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NR 43
TC 1
Z9 1
U1 0
U2 1
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1741-427X
EI 1741-4288
J9 EVID-BASED COMPL ALT
JI Evid.-based Complement Altern. Med.
PY 2017
VL 2017
AR 8128125
DI 10.1155/2017/8128125
PG 8
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA FK2IF
UT WOS:000413305200001
PM 29234430
OA Green Published, hybrid, Green Submitted
DA 2025-06-11
ER

PT J
AU Oda, E
AF Oda, Eiji
TI Cross-Sectional and Longitudinal Associations between Serum Bilirubin
   and Prediabetes in a Health Screening Population
SO CANADIAN JOURNAL OF DIABETES
LA English
DT Article
DE glycated hemoglobin (A1C); oxidative stress; prediabetes; serum
   bilirubin; smoking
ID INSULIN-RESISTANCE; METABOLIC SYNDROME; OXIDATIVE STRESS;
   KIDNEY-DISEASE; RISK-FACTOR; ANTIOXIDANT; DECREASE; ADULTS; WOMEN; MEN
AB Objectives: Longitudinal associations between total bilirubin (TB) and prediabetes have not been reported. This study investigated cross-sectional and longitudinal associations between TB and prediabetes.
   Methods: Cross-sectional associations between TB and prediabetes were investigated in 3681 nondiabetic subjects. Longitudinal associations between TB and prediabetes over 6 years were investigated in 2149 subjects who were normoglycemic at baseline. Prediabetes was defined as fasting plasma glucose (FPG) levels of >= 5.6 mmol/L or glycated hemoglobin levels of >= 5.7% excluding diabetes.
   Results: The prevalence of prediabetes was 25.4%, and the cumulative incidence of prediabetes during 6 years was 25.5% in a Japanese health screening population. Prevalent prediabetes was significantly associated with the quintiles of TB in nonsmoking men (trend, p<0.001) and women (trend, p=0.012), but not in smoking men (trend, p=0.689). Incident prediabetes was not significantly associated with the quintiles of TB, while it was positively associated with 1 standard deviation increase in TB in nonsmoking men (hazard ratio [95% confidence interval]; 1.21 [1.07 to 1.37], p=0.002).
   Conclusions: TB levels were significantly inversely associated with prevalent prediabetes in nonsmokers, but not in smokers, whereas an inverse association between TB levels and incident prediabetes seemed to be unlikely. (C) 2016 Canadian Diabetes Association.
C1 [Oda, Eiji] Tachikawa Med Ctr, Med Check Up Ctr, Nagachou 2-2-16, Nagaoka, Niigata 9400053, Japan.
RP Oda, E (corresponding author), Tachikawa Med Ctr, Med Check Up Ctr, Nagachou 2-2-16, Nagaoka, Niigata 9400053, Japan.
EM ijie@venus.sannet.ne.jp
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NR 33
TC 4
Z9 4
U1 0
U2 2
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1499-2671
J9 CAN J DIABETES
JI Can. J. Diabetes
PD JUN
PY 2016
VL 40
IS 3
BP 270
EP 275
DI 10.1016/j.jcjd.2016.01.001
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA DR5IK
UT WOS:000379936500013
PM 26971991
DA 2025-06-11
ER

PT J
AU Li, YH
   Sun, CC
   Chen, PM
   Chen, HH
AF Li, Yu-He
   Sun, Chia-Cheng
   Chen, Po-Ming
   Chen, Hsin-Hung
TI SGK1 Target Genes Involved in Heart and Blood Vessel Functions in PC12
   Cells
SO CELLS
LA English
DT Article
DE SGK1; neuron cells; PC12 cells; RNA-seq; gene enrichment
ID GLUCOCORTICOID-INDUCIBLE KINASE; SERUM; EXPRESSION; SUPPRESSION;
   MIGRATION; FAMILY; CANCER
AB Serum and glucocorticoid-regulated kinase 1 (SGK1) is expressed in neuronal cells and involved in the pathogenesis of hypertension and metabolic syndrome, regulation of neuronal function, and depression in the brain. This study aims to identify the cellular mechanisms and signaling pathways of SGK1 in neuronal cells. In this study, the SGK1 inhibitor GSK650394 is used to suppress SGK1 expression in PC12 cells using an in vitro neuroscience research platform. Comparative transcriptomic analysis was performed to investigate the effects of SGK1 inhibition in nervous cells using mRNA sequencing (RNA-seq), differentially expressed genes (DEGs), and gene enrichment analysis. In total, 12,627 genes were identified, including 675 and 2152 DEGs at 48 and 72 h after treatment with GSK650394 in PC12 cells, respectively. Gene enrichment analysis data indicated that SGK1 inhibition-induced DEGs were enriched in 94 and 173 genes associated with vascular development and functional regulation and were validated using real-time PCR, Western blotting, and GEPIA2. Therefore, this study uses RNA-seq, DEG analysis, and GEPIA2 correlation analysis to identify positive candidate genes and signaling pathways regulated by SGK1 in rat nervous cells, which will enable further exploration of the underlying molecular signaling mechanisms of SGK1 and provide new insights into neuromodulation in cardiovascular diseases.
C1 [Li, Yu-He] Kaohsiung Armed Forces Gen Hosp, Zuoying Branch, Dept Lab Med, Kaohsiung 813, Taiwan.
   [Sun, Chia-Cheng] Show Chwan Mem Hosp, Phys Examinat Ctr, Changhua 500, Taiwan.
   [Chen, Po-Ming] Show Chwan Mem Hosp, Res Assistant Ctr, Changhua 500, Taiwan.
   [Chen, Hsin-Hung] Kaohsiung Vet Gen Hosp, Dept Med Educ & Res, Kaohsiung 813, Taiwan.
C3 Show Chwan Memorial Hospital; Show Chwan Memorial Hospital; Kaohsiung
   Veterans General Hospital
RP Chen, HH (corresponding author), Kaohsiung Vet Gen Hosp, Dept Med Educ & Res, Kaohsiung 813, Taiwan.
EM derekchen@vghks.gov.tw
RI Chen, PoMing/KGL-1094-2024; Chen, Hsin-Hung/IAM-3877-2023
OI Li, Yu-He/0009-0003-1655-0269; Chen, Po Ming/0000-0002-0824-9615; Chen,
   Hsin-Hung/0000-0002-5662-5945
FU Ministry of Science and Technology of Taiwan [MOST
   110-2320-B-075B-001-MY3]; Kaohsiung Veterans General Hospital
   [KSVGH110-150, KSVGH111-152]; Zouying Branch of Kaohsiung Armed Forces
   General Hospital [KAFGH-ZY-A-110025]
FX This research was funded by the Ministry of Science and Technology of
   Taiwan (MOST 110-2320-B-075B-001-MY3), Kaohsiung Veterans General
   Hospital (KSVGH110-150, and KSVGH111-152), and Zouying Branch of
   Kaohsiung Armed Forces General Hospital (KAFGH-ZY-A-110025). The APC was
   funded by Hsin-Hung Chen.
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NR 44
TC 3
Z9 3
U1 3
U2 5
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2073-4409
J9 CELLS-BASEL
JI Cells
PD JUN
PY 2023
VL 12
IS 12
AR 1641
DI 10.3390/cells12121641
PG 18
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA K1TG3
UT WOS:001014332100001
PM 37371111
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Tomeno, W
   Imajo, K
   Takayanagi, T
   Ebisawa, Y
   Seita, K
   Takimoto, T
   Honda, K
   Kobayashi, T
   Nogami, A
   Kato, T
   Honda, Y
   Kessoku, T
   Ogawa, Y
   Kirikoshi, H
   Sakamoto, Y
   Yoneda, M
   Saito, S
   Nakajima, A
AF Tomeno, Wataru
   Imajo, Kento
   Takayanagi, Takuya
   Ebisawa, Yu
   Seita, Kosuke
   Takimoto, Tsuneyuki
   Honda, Kanami
   Kobayashi, Takashi
   Nogami, Asako
   Kato, Takayuki
   Honda, Yasushi
   Kessoku, Takaomi
   Ogawa, Yuji
   Kirikoshi, Hiroyuki
   Sakamoto, Yasunari
   Yoneda, Masato
   Saito, Satoru
   Nakajima, Atsushi
TI Complications of Non-Alcoholic Fatty Liver Disease in Extrahepatic
   Organs
SO DIAGNOSTICS
LA English
DT Review
DE non-alcoholic fatty liver disease; non-alcoholic steatohepatitis;
   extrahepatic complications; chronic kidney disease; colorectal cancer;
   major depressive disorder; gastroesophageal reflux disease; obstructive
   sleep apnea syndrome; periodontitis; hypothyroidism
ID CHRONIC KIDNEY-DISEASE; OBSTRUCTIVE SLEEP-APNEA; GASTROESOPHAGEAL-REFLUX
   SYMPTOMS; POSITIVE AIRWAY PRESSURE; AMINOTRANSFERASE LEVELS;
   CARDIOVASCULAR-DISEASE; HIGH PREVALENCE; RISK-FACTOR; ASSOCIATION;
   DEPRESSION
AB Non-alcoholic fatty liver disease (NAFLD) is now recognized as the most common chronic liver disease worldwide, along with the concurrent epidemics of metabolic syndrome and obesity. Patients with NAFLD have increased risks of end-stage liver disease, hepatocellular carcinoma, and liver-related mortality. However, the largest cause of death among patients with NAFLD is cardiovascular disease followed by extrahepatic malignancies, whereas liver-related mortality is only the third cause of death. Extrahepatic complications of NAFLD include chronic kidney disease, extrahepatic malignancies (such as colorectal cancer), psychological dysfunction, gastroesophageal reflux disease, obstructive sleep apnea syndrome, periodontitis, hypothyroidism, growth hormone deficiency, and polycystic ovarian syndrome. The objective of this narrative review was to summarize recent evidences about extrahepatic complications of NAFLD, with focus on the prevalent/incident risk of such diseases in patients with NAFLD. To date, an appropriate screening method for extrahepatic complications has not yet been determined. Collaborative care with respective experts seems to be necessary for patient management because extrahepatic complications can occur across multiple organs. Further studies are needed to reveal risk profiles at baseline and to determine an appropriate screening method for extrahepatic diseases.
C1 [Tomeno, Wataru; Takayanagi, Takuya; Ebisawa, Yu; Seita, Kosuke; Takimoto, Tsuneyuki; Honda, Kanami; Kato, Takayuki; Sakamoto, Yasunari] Int Univ Hlth & Welf, Atami Hosp, Dept Gastroenterol, 13-1 Higashikaigancho, Atami, Shizuoka 4130012, Japan.
   [Tomeno, Wataru; Imajo, Kento; Takayanagi, Takuya; Ebisawa, Yu; Seita, Kosuke; Takimoto, Tsuneyuki; Honda, Kanami; Kobayashi, Takashi; Nogami, Asako; Kato, Takayuki; Honda, Yasushi; Kessoku, Takaomi; Ogawa, Yuji; Sakamoto, Yasunari; Yoneda, Masato; Saito, Satoru; Nakajima, Atsushi] Yokohama City Univ, Grad Sch Med, Dept Gastroenterol & Hepatol, Kanazawa Ku, 3-9 Fukuura, Yokohama, Kanagawa 2360004, Japan.
   [Kirikoshi, Hiroyuki] Yokohama City Univ Med, Dept Clin Lab, Kanazawa Ku, 3-9 Fukuura, Yokohama, Kanagawa 2360004, Japan.
C3 International University of Health & Welfare; Yokohama City University;
   Yokohama City University
RP Nakajima, A (corresponding author), Yokohama City Univ, Grad Sch Med, Dept Gastroenterol & Hepatol, Kanazawa Ku, 3-9 Fukuura, Yokohama, Kanagawa 2360004, Japan.
EM tomeno-ykh@umin.ac.jp; kento318@yokohama-cu.ac.jp; ttakimoto8@gmail.com;
   you.ebisawa603@gmail.com; innocent_society@yahoo.co.jp;
   ttakimoto8@gmail.com; kanamin.ni@gmail.com; tkhkcb@gmail.com;
   a06m071@yahoo.co.jp; takaomi0027@gmail.com; y-honda@umin.ac.jp;
   t.kato222@iuhw.ac.jp; ogaway@yokohama-cu.ac.jp;
   hkirikos@yokohama-cu.ac.jp; yasakamo@iuhw.ac.jp; yoneda-ycu@umin.ac.jp;
   ssai1423@yokohama-cu.ac.jp; nakajima-tky@umin.ac.jp
RI Nogami, Asako/HLP-4920-2023; KOBAYASHI, Takashi/AAM-7549-2021
OI Nogami, Asako/0000-0002-6923-365X; Honda, Yasushi/0000-0002-1624-5462;
   Nakajima, Atsushi/0000-0002-6263-1436; Kobayashi,
   Takashi/0000-0002-7240-4851; Imajo, Kento/0000-0002-1931-6326
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NR 72
TC 26
Z9 30
U1 1
U2 19
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2075-4418
J9 DIAGNOSTICS
JI Diagnostics
PD NOV
PY 2020
VL 10
IS 11
AR 912
DI 10.3390/diagnostics10110912
PG 12
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA OW3RF
UT WOS:000592807600001
PM 33171865
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Woo, YS
   Seo, HJ
   McIntyre, RS
   Bahk, WM
AF Woo, Young Sup
   Seo, Hye-Jin
   McIntyre, Roger S.
   Bahk, Won-Myong
TI Obesity and Its Potential Effects on Antidepressant Treatment Outcomes
   in Patients with Depressive Disorders: A Literature Review
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE depressive disorder; obesity; antidepressant; response; treatment
   outcome
ID GLYCOGEN-SYNTHASE KINASE-3; LASTING DIABETES-MELLITUS; OMENTAL
   ADIPOSE-TISSUE; BODY-MASS INDEX; TREATMENT RESISTANCE;
   INSULIN-RESISTANCE; GENDER-DIFFERENCES; METABOLIC SYNDROME; MAJOR
   DEPRESSION; BIPOLAR DISORDER
AB Accumulating evidence regarding clinical, neurobiological, genetic, and environmental factors suggests a bidirectional link between obesity and depressive disorders. Although a few studies have investigated the link between obesity/excess body weight and the response to antidepressants in depressive disorders, the effect of weight on treatment response remains poorly understood. In this review, we summarized recent data regarding the relationship between the response to antidepressants and obesity/excess body weight in clinical studies of patients with depressive disorders. Although several studies indicated an association between obesity/excess body weight and poor antidepressant responses, it is difficult to draw definitive conclusions due to the variability of subject composition and methodological differences among studies. Especially, differences in sex, age and menopausal status, depressive symptom subtypes, and antidepressants administered may have caused inconsistencies in the results among studies. The relationship between obesity/excess body weight and antidepressant responses should be investigated further in high-powered studies addressing the differential effects on subject characteristics and treatment. Moreover, future research should focus on the roles of mediating factors, such as inflammatory markers and neurocognitive performance, which may alter the antidepressant treatment outcome in patients with comorbid obesity and depressive disorder.
C1 [Woo, Young Sup; Seo, Hye-Jin; Bahk, Won-Myong] Catholic Univ Korea, Dept Psychiat, Coll Med, Seoul 07345, South Korea.
   [Woo, Young Sup; McIntyre, Roger S.] Univ Hlth Network, Mood Disorders Psychopharmacol Unit, Toronto, ON M5T 2S8, Canada.
   [McIntyre, Roger S.] Univ Toronto, Dept Psychiat, Toronto, ON M5T 2S8, Canada.
C3 Catholic University of Korea; University of Toronto; University Health
   Network Toronto; University of Toronto
RP Bahk, WM (corresponding author), Catholic Univ Korea, Dept Psychiat, Coll Med, Seoul 07345, South Korea.
EM youngwool@catholic.ac.kr; carpe-diem80@daum.net; Roger.McIntyre@uhn.ca;
   wmbahk@catholic.ac.kr
RI Seo, Hye/C-6900-2015; McIntyre, Roger/AAU-1000-2020
FU Lundbeck; Astra Zeneca; Pfizer; Shire; Otsuka; Bristol Myers Squibb;
   National Institute of Mental Health; Stanley Medical Research Institute;
   Canadian Institutes for Health Research; Brain and Behavior Research
   Foundation; Elli Lilly; Janssen Ortho; Sunovion; Takeda; Forest
FX Roger S. McIntyre has received research grant support from Lundbeck,
   Astra Zeneca, Pfizer, Shire, Otsuka, Bristol Myers Squibb, National
   Institute of Mental Health, Stanley Medical Research Institute, Canadian
   Institutes for Health Research, and The Brain and Behavior Research
   Foundation. Roger S. McIntyre has also received speaker/consultant fees
   from Lundbeck, Pfizer, Astra Zeneca, Elli Lilly, Janssen Ortho,
   Sunovion, Takeda, Forest, Otsuka, Bristol Myers Squibb, and Shire.
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NR 171
TC 51
Z9 62
U1 0
U2 17
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD JAN
PY 2016
VL 17
IS 1
AR 80
DI 10.3390/ijms17010080
PG 20
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA DK0DW
UT WOS:000374583800077
PM 26771598
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Sengul, C
   Ozveren, O
   Duman, D
   Eroglu, E
   Oduncu, V
   Tanboga, HI
   Can, MM
   Akgun, T
   Dindar, I
AF Sengul, Cihan
   Ozveren, Olcay
   Duman, Dursun
   Eroglu, Elif
   Oduncu, Vecih
   Tanboga, Halil Ibrahim
   Can, Mehmet Mustafa
   Akgun, Taylan
   Dindar, Ismet
TI Echocardiographic epicardial fat thickness is related to altered blood
   pressure responses to exercise stress testing
SO BLOOD PRESSURE
LA English
DT Article
DE Blood pressure recovery index; echocardiography; epicardial fat;
   exercise stress test; hypertension; visceral adiposity
ID BETA-CELL FUNCTION; ADIPOSE-TISSUE; INSULIN-RESISTANCE; VISCERAL FAT;
   HYPERTENSION; OBESITY; RISK; HYPERTROPHY; ADIPONECTIN; HEART
AB Objective. Hypertensive response at peak exercise and blunted blood pressure (BP) recovery, altered BP responses obtained from exercise stress testing, have been suggested as risk factors for future onset of hypertension in previous studies. Epicardial fat, a new cardiometabolic risk factor, has been linked to hypertension in some recent studies. In this study, we tested the primary hypothesis suggesting that the epicardial fat thickness (EFT) is related to altered BP responses to treadmill exercise testing. We also evaluated the sensitivity and specificity of the EFT as a predictor of hypertensive response to peak exercise. Methods. Normotensive subjects underwent to treadmill stress testing and transthoracic echocardiography. Hypertensive response to peak treadmill exercise testing was defined as >= 210/105 mmHg and >= 190/105 mmHg at peak exercise in males and females, respectively. BP recovery index (BPRI) was defined as the ratio of the BP at the 3rd minute of the recovery phase to BP at peak exercise. EFT was measured by echocardiography. Thirty-two subjects with hypertensive response to peak exercise constituted Group 1 and 48 subjects with normal response constituted Group 2. Results. The mean EFT of subjects in Group 1 was significantly higher (8.2 +/- 1.1 mm vs 5.1 +/- 1.5 mm; p = 0.0001) than subjects in Group 2. In correlation analysis performed in Group 1, EFT was found to be significantly correlated with BPRI (r = 0.51, p < 0.003). An EFT of >= 6.5 mm predicted the hypertensive response to peak exercise test with 68.8% sensitivity and 87.5% specificity (receiving operator characteristic area under curve: 0.879, 95% CI 0.793-0.965, p < 0.001). Patients with EFT >= 6.5 mm showed a significantly increased BPRI (0.89 +/- 0.07 vs 0.74 +/- 0.09, p < 0.0001) and peak systolic BP (198.4 +/- 15.3 mmHg vs 169.4 +/- 19.8 mmHg, p < 0.0001). There were significant differences in metabolic equivalents, maximum heart rate, homeostatic model assessment of insulin resistance, high-density lipoprotein-cholesterol, waist circumference and age values between two patients groups dichotomized according to the cut-off value of EFT. BPRI was the only independent variable related to EFT in the multivariate analysis (odds ratio = 1.4, 95% CI 2.75-7.16, p = 0.001). Conclusions. EFT was found to be related to altered BP responses to exercise stress testing. The echocardiographic measurement of EFT may serve as a useful non-invasive indicator of heightened risk of future hypertension.
C1 [Sengul, Cihan; Dindar, Ismet] Goztepe Med Pk Hosp, Dept Cardiol, Istanbul, Turkey.
   [Ozveren, Olcay; Eroglu, Elif; Oduncu, Vecih; Tanboga, Halil Ibrahim; Can, Mehmet Mustafa; Akgun, Taylan] Kartal Kosuyolu Heart & Res Hosp, Dept Cardiol, Istanbul, Turkey.
   [Duman, Dursun] Medipol Univ, Sch Med, Dept Cardiol, Istanbul, Turkey.
C3 Medical Park Hospitals Group; Istanbul Kartal Kosuyolu Yuksek Ihtisas
   Training & Research Hospital; Istanbul Medipol University
RP Sengul, C (corresponding author), Goztepe Med Pk Hosp, Dept Cardiol, Istanbul, Turkey.
EM drcsengul@yahoo.com
RI Eroglu, Elif/T-7450-2017; Duman, Dursun/B-5558-2015; AKGUN,
   Taylan/ABH-8172-2020; Tanboga, Ibrahim/E-8886-2010
OI ODUNCU, Vecih/0000-0001-8221-9230; AKGUN, Taylan/0000-0002-5395-2027;
   Tanboga, Ibrahim Halil/0000-0003-4546-9227
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NR 25
TC 15
Z9 16
U1 0
U2 4
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
EI 1651-1999
J9 BLOOD PRESSURE
JI Blood Pressure
PD OCT
PY 2011
VL 20
IS 5
BP 303
EP 308
DI 10.3109/08037051.2011.569992
PG 6
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 823MH
UT WOS:000295125900008
PM 21438844
OA Bronze
DA 2025-06-11
ER

PT J
AU Gherasim, A
   Oprescu, AC
   Gal, AM
   Burlui, AM
   Mihalache, L
AF Gherasim, Andreea
   Oprescu, Andrei C.
   Gal, Ana Maria
   Burlui, Alexandra Maria
   Mihalache, Laura
TI Lifestyle Patterns in Patients with Type 2 Diabetes
SO METABOLITES
LA English
DT Article
DE lifestyle; pattern; diet; diabetes
ID PHYSICAL-ACTIVITY QUESTIONNAIRE; TELEVISION VIEWING TIME; METABOLIC
   SYNDROME; CARDIOVASCULAR-DISEASE; DIETARY PATTERNS; SITTING TIME;
   RISK-FACTORS; WEIGHT-GAIN; EXERCISE; OBESITY
AB Modern lifestyles have led to sedentary behavior, lower participation in active movement and physical activities during leisure time, unhealthy diets, and increased exposure to stress. It is important to examine the interaction of several lifestyle risk factors instead of focusing on one alone. The purpose of this study was to identify lifestyle patterns in a group of patients with type 2 diabetes and the associations of its components with certain metabolic parameters. Using principal component analysis, we identified three dietary patterns: the prudent pattern (fat, oil, cereals, potatoes, vegetables, fish, nuts, seeds and fruits), the Western pattern (meat and meat products, eggs and soft drinks) and the traditional pattern (milk and its derivatives, soups and sauces, with a low intake of sugar/snacks). In addition, using the same method of analysis, we identified two lifestyle patterns: the inadequate lifestyle pattern (Western dietary pattern, increased hours of sleep and lower levels of stress) and the traditional lifestyle pattern (traditional dietary pattern, increased physical activity (PA) and non-smoking status). The inadequate lifestyle pattern was associated with younger age, hypertension and diabetic neuropathy. The traditional lifestyle pattern was related to lower postprandial blood glucose levels. Sedentary individuals were more likely to be over 65 years old and to have higher glycated hemoglobin (HbA1c). Smokers were also more likely to have inadequate glycemic and lipid profile control.
C1 [Gherasim, Andreea; Mihalache, Laura] Grigore T Popa Univ Med & Pharm, Dept Internal Med, Iasi 700115, Romania.
   [Oprescu, Andrei C.] Grigore T Popa Univ Med & Pharm, Dept Morphofunct Studies, Iasi 700115, Romania.
   [Gal, Ana Maria] Grigore T Popa Univ Med & Pharm, Coll Med, Iasi 700115, Romania.
   [Burlui, Alexandra Maria] Grigore T Popa Univ Med & Pharm, Dept Rheumatol & Med Rehabil, Iasi 700115, Romania.
C3 Grigore T Popa University of Medicine & Pharmacy; Grigore T Popa
   University of Medicine & Pharmacy; Grigore T Popa University of Medicine
   & Pharmacy; Grigore T Popa University of Medicine & Pharmacy
RP Gherasim, A (corresponding author), Grigore T Popa Univ Med & Pharm, Dept Internal Med, Iasi 700115, Romania.
EM andreea.gherasim@umfiasi.ro; andrei-catalin-a-oprescu@d.umfiasi.ro;
   ana-maria.a.ilisei@d.umfiasi.ro; alexandra.burlui@umfiasi.ro;
   laura.mihalache@umfiasi.ro
RI Mihalache, Laura/KFB-0411-2024; Gherasim, Andreea/KZU-9980-2024; Burlui,
   Alexandra/U-5735-2017; Gal, Ana Maria/KPY-1788-2024
OI Gal, Ana-Maria/0000-0003-0986-3227
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   [Anonymous], 2010, GLOB REC PHYS ACT HL
   [Anonymous], 2022, DIET GUID AM 2020 20, V9th
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NR 83
TC 4
Z9 4
U1 3
U2 8
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2218-1989
J9 METABOLITES
JI Metabolites
PD JUL
PY 2023
VL 13
IS 7
AR 831
DI 10.3390/metabo13070831
PG 16
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA N4FU0
UT WOS:001036596700001
PM 37512538
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Dannawi, M
   Riachi, ME
   Haddad, AF
   El Massry, M
   Haddad, M
   Moukarzel, P
   Harb, F
   Ghadieh, HE
   Eid, AA
AF Dannawi, Maya
   Riachi, Mansour E.
   Haddad, Antony F.
   El Massry, Mohamed
   Haddad, Mary
   Moukarzel, Pamela
   Harb, Frederic
   Ghadieh, Hilda E.
   Eid, Assaad A.
TI Influence of intermittent fasting on prediabetes-induced neuropathy:
   Insights on a novel mechanistic pathway
SO METABOLISM OPEN
LA English
DT Article
DE Intermittent fasting; Reactive oxygen species; Diabetic peripheral
   neuropathy; Diabetes; Oxidative stress
ID SOLUBLE EPOXIDE HYDROLASE; INDUCED OXIDATIVE STRESS;
   DIABETIC-NEUROPATHY; ARACHIDONIC-ACID; MOUSE MODEL; CYTOCHROME-P450;
   GLUCOSE; INHIBITION; OBESITY; RISK
AB Aims: Peripheral neuropathy (PN) is correlated with obesity and metabolic syndrome. Intermittent fasting (IF) has been described as the cornerstone in the management of obesity; however, its role in prediabetic complications is not well elucidated. Cytochromes P450 Monooxygenases (CYP450) are major sources of Reactive Oxygen Species (ROS) that orchestrate the onset and development of diabetic complications. One of the CYPmetabolites, Expoxyecosatetraenoic Acids (EETs), are considered to be negative regulators of ROS production. In this study, we elucidated the role of IF on ROS production and investigated its influence on prediabetesinduced PN. Methods: C57/BL6 control mice, prediabetic, prediabetic that underwent alternate day fasting with different diet composition, and prediabetic mice treated with EET-metabolizing sEH-inhibitor, AUDA. Body mass composition, metabolic, behavioral, and molecular tests were performed. Results: High -fat diet (HFD) led to an increase in NADPH-induced ROS production; that was due to an alteration in the epoxygenase pathway assessed by the decrease in CYP1a1/1a2 expression. IF reinstated the homeostatic levels of EETs in HFD-fed mice. Moreover, treatment with AUDA mimicked the beneficial effect observed with IF. Conclusion: IF and EETs bioavailability have a protective role in prediabetes-induced PN, suggesting a novel interventional strategy in the management of prediabetes and its associated complications.
C1 [Dannawi, Maya; Riachi, Mansour E.; Haddad, Antony F.; El Massry, Mohamed; Haddad, Mary; Moukarzel, Pamela; Ghadieh, Hilda E.; Eid, Assaad A.] Amer Univ Beirut, Fac Med, Dept Anat Cell Biol & Physiol Sci, Beirut, Lebanon.
   [Dannawi, Maya; Riachi, Mansour E.; Haddad, Antony F.; El Massry, Mohamed; Haddad, Mary; Moukarzel, Pamela; Ghadieh, Hilda E.; Eid, Assaad A.] Amer Univ Beirut, Med Ctr, Beirut, Lebanon.
   [Dannawi, Maya; Riachi, Mansour E.; Haddad, Antony F.; El Massry, Mohamed; Haddad, Mary; Moukarzel, Pamela; Ghadieh, Hilda E.; Eid, Assaad A.] Amer Univ Beirut, Fac Med, AUB Diabet, Med Ctr, Beirut, Lebanon.
   [Harb, Frederic] Lebanese Univ, Fac Sci, Dept Life & Earth Sci, Fanar, Lebanon.
   [Eid, Assaad A.] Amer Univ Beirut, Fac Med, Dept Anat Cell Biol & Physiol Sci, Bliss St 11-0236, Riad El Solh 11072020, Lebanon.
   [Eid, Assaad A.] Amer Univ Beirut, Med Ctr, Bliss St 11-0236, Riad El Solh 11072020, Lebanon.
C3 American University of Beirut; American University of Beirut; American
   University of Beirut; Lebanese University; American University of
   Beirut; American University of Beirut
RP Eid, AA (corresponding author), Amer Univ Beirut, Fac Med, Dept Anat Cell Biol & Physiol Sci, Bliss St 11-0236, Riad El Solh 11072020, Lebanon.; Eid, AA (corresponding author), Amer Univ Beirut, Med Ctr, Bliss St 11-0236, Riad El Solh 11072020, Lebanon.
EM ae49@aub.edu.lb
RI Harb, Frederic/O-4587-2019; Eid, Ahmad/AAE-7047-2020
OI Eid, Assaad/0000-0002-3603-0960; Riachi, Mansour/0000-0002-2790-8700;
   Moukarzel, Pamela/0009-0008-6021-5333
FU AUB medical practice plan
FX Grant from AUB medical practice plan.
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NR 63
TC 6
Z9 6
U1 1
U2 3
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
EI 2589-9368
J9 METAB OPEN
JI Metab. Open
PD JUN
PY 2022
VL 14
AR 100175
DI 10.1016/j.metop.2022.100175
PG 8
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA JF0R1
UT WOS:001171636700010
PM 35402890
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Moreno-Arriola, E
   El Hafidi, M
   Ortega-Cuéllar, D
   Carvajal, K
AF Moreno-Arriola, Elizabeth
   El Hafidi, Mohammed
   Ortega-Cuellar, Daniel
   Carvajal, Karla
TI AMP-Activated Protein Kinase Regulates Oxidative Metabolism in
   Caenorhabditis elegans through the NHR-49 and MDT-15
   Transcriptional Regulators
SO PLOS ONE
LA English
DT Article
ID FATTY-ACID-COMPOSITION; LIFE-SPAN; DIETARY RESTRICTION; C. ELEGANS;
   PPAR-ALPHA; GLUCOSE; INCREASES; PATHWAY; STRESS; AAK-2
AB Cellular energy regulation relies on complex signaling pathways that respond to fuel availability and metabolic demands. Dysregulation of these networks is implicated in the development of human metabolic diseases such as obesity and metabolic syndrome. In Caenorhabditis elegans the AMP-activated protein kinase, AAK, has been associated with longevity and stress resistance; nevertheless its precise role in energy metabolism remains elusive. In the present study, we find an evolutionary conserved role of AAK in oxidative metabolism. Similar to mammals, AAK is activated by AICAR and metformin and leads to increased glycolytic and oxidative metabolic fluxes evidenced by an increase in lactate levels and mitochondrial oxygen consumption and a decrease in total fatty acids and lipid storage, whereas augmented glucose availability has the opposite effects. We found that these changes were largely dependent on the catalytic subunit AAK-2, since the aak-2 null strain lost the observed metabolic actions. Further results demonstrate that the effects due to AAK activation are associated to SBP-1 and NHR-49 transcriptional factors and MDT-15 transcriptional co-activator, suggesting a regulatory pathway that controls oxidative metabolism. Our findings establish C. elegans as a tractable model system to dissect the relationship between distinct molecules that play a critical role in the regulation of energy metabolism in human metabolic diseases.
C1 [Moreno-Arriola, Elizabeth; Ortega-Cuellar, Daniel; Carvajal, Karla] Inst Nacl Pediat, Lab Nutr Expt, Mexico City, DF, Mexico.
   [El Hafidi, Mohammed] Inst Nacl Cardiol, Dept Biomed Cardiovasc, Mexico City, DF, Mexico.
C3 National Institute of Cardiology - Mexico
RP Carvajal, K (corresponding author), Inst Nacl Pediat, Lab Nutr Expt, Mexico City, DF, Mexico.
EM karla_ca@yahoo.com
RI El-Hafidi, Mohammed/AAN-4083-2021
OI Ortega-Cuellar, Daniel/0000-0001-7950-4911; Moreno-Arriola,
   Elizabeth/0000-0003-0160-6429; CARVAJAL, KARLA/0000-0002-5522-3266
FU Consejo Nacional de Ciencia y Tecnologia (CONACyT) [239732]
FX The authors received no specific funding for this work. The authors
   thank Consejo Nacional de Ciencia y Tecnologia (CONACyT) for PhD
   scholarship (239732) given to EMA. EMA is a Ph.D. student at Programa de
   Doctorado en Ciencias Biomedicas, Facultad de Medicina, Universidad
   Nacional Autonoma de Mexico (UNAM, Mexico). The funders had no role in
   study design, data collection and analysis, decision to publish, or
   preparation of the manuscript. We thank Consejo Nacional de Ciencia y
   Tecnologia (CONACyT) for PhD scholarship (239732) given to Elizabeth
   Moreno-Arriola (EMA). EMA is a Ph.D. student at Programa de Doctorado en
   Ciencias Biomedicas, Facultad de Medicina, Universidad Nacional Autonoma
   de Mexico (UNAM, Mexico). We greatly thank Reyna Hernandez-Morales and
   Patricia Zarate-Grajales for technical assistance. The funders had no
   role in study design, data collection and analysis, decision to publish,
   or preparation of the manuscript.
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NR 70
TC 42
Z9 51
U1 1
U2 27
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JAN 29
PY 2016
VL 11
IS 1
AR e0148089
DI 10.1371/journal.pone.0148089
PG 20
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA DC9GH
UT WOS:000369528600097
PM 26824904
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Tahara, A
   Kurosaki, E
   Yokono, M
   Yamajuku, D
   Kihara, R
   Hayashizaki, Y
   Takasu, T
   Imamura, M
   Li, Q
   Tomiyama, H
   Kobayashi, Y
   Noda, A
   Sasamata, M
   Shibasaki, M
AF Tahara, Atsuo
   Kurosaki, Eiji
   Yokono, Masanori
   Yamajuku, Daisuke
   Kihara, Rumi
   Hayashizaki, Yuka
   Takasu, Toshiyuki
   Imamura, Masakazu
   Li, Qun
   Tomiyama, Hiroshi
   Kobayashi, Yoshinori
   Noda, Atsushi
   Sasamata, Masao
   Shibasaki, Masayuki
TI Effects of SGLT2 selective inhibitor ipragliflozin on hyperglycemia,
   hyperlipidemia, hepatic steatosis, oxidative stress, inflammation, and
   obesity in type 2 diabetic mice
SO EUROPEAN JOURNAL OF PHARMACOLOGY
LA English
DT Article
DE Ipragliflozin; SGLT2; Hyperglycemia; Urinary glucose excretion; Diabetes
ID NONALCOHOLIC FATTY LIVER; BETA-CELL FUNCTION; GLYCEMIC CONTROL; DIET;
   COTRANSPORTER; INSULIN; ROSIGLITAZONE; SULFONYLUREA; ASSOCIATION;
   MELLITUS
AB The sodium glucose cotransporter 2 (SGLT(2)) is responsible for most glucose reabsorption in the kidney and has been proposed as a novel therapeutic target for the treatment of type 2 diabetes. In the present study, the therapeutic effects of SGLT2 selective inhibitor ipragliflozin were examined in high-fat diet and streptozotocin-nicotinamide-induced type 2 diabetic mice which exhibit impaired insulin secretion, insulin resistance, hyperlipidemia, hepatic steatosis, and obesity. Single administration of ipragliflozin dose-dependently increased urinary glucose excretion, reduced blood glucose and plasma insulin levels, and improved glucose intolerance. Four-week repeated administration of ipragliflozin improved not only glucose tolerance, hyperglycemia, and hyperinsulinemia but also impaired insulin secretion, hyperlipidemia, hepatic steatosis, and obesity with a concomitant increase in urinary glucose excretion. In addition, ipragliflozin reduced plasma and liver levels of oxidative stress biomarkers (thiobarbituric acid reactive substances and protein carbonyl) and inflammatory markers (interleukin 6, tumor necrosis factor a, monocyte chemotactic protein 1, and c-reactive protein), and improved liver injury as assessed by plasma levels of aminotransferases. These results demonstrate that SGLT2 selective inhibitor ipragliflozin improves not only hyperglycemia but also diabetes/obesity-associated metabolic abnormalities in type 2 diabetic mice and suggest that ipragliflozin may be useful in treating type 2 diabetes with metabolic syndrome. (C) 2013 Elsevier B.V. All rights reserved.
C1 [Tahara, Atsuo; Kurosaki, Eiji; Yokono, Masanori; Yamajuku, Daisuke; Kihara, Rumi; Hayashizaki, Yuka; Takasu, Toshiyuki; Imamura, Masakazu; Sasamata, Masao; Shibasaki, Masayuki] Astellas Pharma Inc, Drug Discovery Res, Ibaraki, Japan.
   [Li, Qun] Astellas Pharma Europe BV, Appl Pharmacol Res Labs, Leiderdorp, Netherlands.
   [Tomiyama, Hiroshi] Kotobuki Pharmaceut Co Ltd, Res & Dev Dept, Prod Planning & Coordinat Div, Nagano, Japan.
   [Kobayashi, Yoshinori; Noda, Atsushi] Kotobuki Pharmaceut Co Ltd, Res Labs, Synthet Div, Nagano, Japan.
C3 Astellas Pharmaceuticals; Astellas Pharmaceuticals
RP Tahara, A (corresponding author), Astellas Pharma Inc, Drug Discovery Res, 21 Miyukigaoka, Tsukuba, Ibaraki 3058585, Japan.
EM atsuo.tahara@jp.astellas.com
RI Li, Qun/ABA-5241-2021
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NR 40
TC 256
Z9 265
U1 1
U2 57
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0014-2999
EI 1879-0712
J9 EUR J PHARMACOL
JI Eur. J. Pharmacol.
PD SEP 5
PY 2013
VL 715
IS 1-3
BP 246
EP 255
DI 10.1016/j.ejphar.2013.05.014
PG 10
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 213AQ
UT WOS:000324025700034
PM 23707905
DA 2025-06-11
ER

PT J
AU Nakagawa, T
   Andres-Hernando, A
   Kosugi, T
   Sanchez-Lozada, LG
   Stenvinkel, P
   Kublickiene, K
   Karumanchi, SA
   Kang, DH
   Kojima, H
   Rodriguez-Iturbe, B
   Tolan, DR
   Lanaspa, MA
   Johnson, RJ
AF Nakagawa, Takahiko
   Andres-Hernando, Ana
   Kosugi, Tomoki G.
   Sanchez-Lozada, Laura
   Stenvinkel, Peter
   Kublickiene, Karolina
   Karumanchi, S. Ananth
   Kang, Duk-Hee
   Kojima, Hideto
   Rodriguez-Iturbe, Bernardo R.
   Tolan, Dean A.
   Lanaspa, Miguel J.
   Johnson, Richard
TI Fructose might be a clue to the origin of preeclampsia insights from
   nature and evolution
SO HYPERTENSION RESEARCH
LA English
DT Review
DE Fructose; Sugar; Preeclampsia; Uric acid; Hypoxia; Vasopressin
ID URIC-ACID; METABOLIC SYNDROME; OXIDATIVE STRESS; 1ST TRIMESTER;
   PREGNANCY; HYPERURICEMIA; CONSUMPTION; GLUCOKINASE; MECHANISM; PRODUCTS
AB Preeclampsia is a hypertensive disorder of pregnancy and is due to abnormal placentation. The pathogenesis remains unclear. Fructose is biologically distinct from glucose and has a critical role in fetal growth in early pregnancy. Many species, including humans, produce fructose in their placenta during the first trimester to assist fetal growth and survival during a time when hypoxia is significant. Fructose is preferred over glucose in hypoxic tissues, and in the developing fetus, fructose has a critical role in stimulating the production of nucleic acids, lipids and glycosaminoglycans. Fructose production normally decreases significantly following the establishment of maternal-fetal circulation following placentation. However, if there is impaired placentation, local hypoxia will continue to drive fructose production. Excessive fructose metabolism drives endothelial dysfunction, oxidative stress, elevated blood pressure, insulin resistance, fatty liver, and a rise in uric acid and vasopressin levels, all of which are features of the preeclamptic state. In addition to fructose production, dietary fructose, for example, from soft drinks, would be additive and has been reported to be a strong independent risk factor for preeclampsia. Uric acid-associated endothelial dysfunction disturbs the invasion of the spiral artery, leading to placental ischemia and further placental hypoxia. Here, we summarize the previous literature regarding the physiological and pathological roles of fructose in pregnancy and propose studies to further investigate the pathogenesis of preeclampsia.
C1 [Nakagawa, Takahiko; Kojima, Hideto] Shiga Univ Med Sci, Dept Regenerat Med Dev, Shiga, Japan.
   [Nakagawa, Takahiko; Kojima, Hideto] Shiga Univ Med Sci, Dept Biocommun Dev, Shiga, Japan.
   [Andres-Hernando, Ana; Lanaspa, Miguel J.; Johnson, Richard] Univ Colorado, Div Renal Dis & Hypertens, Denver, CO USA.
   [Kosugi, Tomoki G.] Nagoya Univ, Grad Sch Med, Dept Nephrol, Nagoya, Japan.
   [Sanchez-Lozada, Laura] Inst Nacl Cardiol Ignacio Chavez, Dept Cardiorenal Physiopathol, Mexico City 14080, Mexico.
   [Stenvinkel, Peter; Kublickiene, Karolina] Karolinska Inst, Dept Clin Sci Intervent & Technol, Div Renal Med, Stockholm, Sweden.
   [Karumanchi, S. Ananth] Cedars Sinai Med Ctr, Dept Med, Los Angeles, CA USA.
   [Kang, Duk-Hee] Ewha Womans Univ, Ewha Med Res Ctr, Dept Internal Med, Div Nephrol,Coll Med, Seoul, South Korea.
   [Rodriguez-Iturbe, Bernardo R.] Inst Nacl Cardiol Ignacio Chavez, Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Nephrol, Mexico City 14080, Mexico.
   [Tolan, Dean A.] Boston Univ, Dept Biol, Boston, MA USA.
   [Johnson, Richard] Rocky Mt Vet Adm Hosp, Div Kidney Dis, Aurora, CO USA.
C3 Shiga University of Medical Science; Shiga University of Medical
   Science; University of Colorado System; University of Colorado Denver;
   Nagoya University; National Institute of Cardiology - Mexico; Karolinska
   Institutet; Cedars Sinai Medical Center; Ewha Womans University;
   National Institute of Cardiology - Mexico; Instituto Nacional de
   Ciencias Medicas y Nutricion Salvador Zubiran - Mexico; Boston
   University
RP Nakagawa, T (corresponding author), Shiga Univ Med Sci, Dept Regenerat Med Dev, Shiga, Japan.; Nakagawa, T (corresponding author), Shiga Univ Med Sci, Dept Biocommun Dev, Shiga, Japan.
EM nakagawt@gmail.com
RI Sanchez-Lozada, Laura/AAS-2104-2021; Rodriguez-Iturbe,
   Bernardo/KFX-2910-2024
OI Karumanchi, Subbian/0000-0002-2281-6831; Kang,
   Duk-Hee/0000-0001-8475-8932; Tolan, Dean/0000-0002-0598-7241
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NR 60
TC 7
Z9 7
U1 1
U2 6
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0916-9636
EI 1348-4214
J9 HYPERTENS RES
JI Hypertens. Res.
PD MAR
PY 2023
VL 46
IS 3
BP 646
EP 653
DI 10.1038/s41440-022-01121-w
EA DEC 2022
PG 8
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 9O9PM
UT WOS:000901708400004
PM 36539464
DA 2025-06-11
ER

PT J
AU dos Santos, JPM
   de Maio, MC
   Lemes, MA
   Laurindo, LF
   Haber, JFD
   Bechara, MD
   do Prado, PS
   Rauen, EC
   Costa, F
   Pereira, BCD
   Flato, UAP
   Goulart, RD
   Chagas, EFB
   Barbalho, SM
AF dos Santos, Joao Paulo Margiotti
   de Maio, Mariana Canevari
   Lemes, Monike Alves
   Laurindo, Lucas Fornari
   Haber, Jesselina Francisco dos Santos
   Bechara, Marcelo Dib
   do Prado, Pedro Sidnei
   Rauen, Eduardo Costa
   Costa, Fernando
   Pereira, Barbara Cristina de Abreu
   Flato, Uri Adrian Prync
   Goulart, Ricardo de Alvares
   Chagas, Eduardo Federighi Baisi
   Barbalho, Sandra Maria
TI Non-Alcoholic Steatohepatitis (NASH) and Organokines: What Is Now and
   What Will Be in the Future
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE non-alcoholic fatty liver disease; dyslipidemias; oxidative stress;
   inflammation; organokines
ID FATTY LIVER-DISEASE; HEPATOKINES; FRUCTOSE; PATHOGENESIS; METABOLISM;
   ADIPOKINES; PATHOPHYSIOLOGY; INFLAMMATION; INHIBITION; RESISTIN
AB Non-alcoholic steatohepatitis (NASH) is characterized by steatosis, lobular inflammation, and enlargement of the diameter of hepatocytes (ballooning hepatocytes), with or without fibrosis. It affects 20% of patients with non-alcoholic fatty liver disease (NAFLD). Due to liver dysfunction and the numerous metabolic changes that commonly accompany the condition (obesity, insulin resistance, type 2 diabetes, and metabolic syndrome), the secretion of organokines is modified, which may contribute to the pathogenesis or progression of the disease. In this sense, this study aimed to perform a review of the role of organokines in NASH. Thus, by combining descriptors such as NASH, organokines, oxidative stress, inflammation, insulin resistance, and dyslipidemia, a search was carried out in the EMBASE, MEDLINE-PubMed, and Cochrane databases of articles published in the last ten years. Insulin resistance, inflammation and mitochondrial dysfunction, fructose, and intestinal microbiota were factors identified as participating in the genesis and progression of NASH. Changes in the pattern of organokines secretion (adipokines, myokines, hepatokines, and osteokines) directly or indirectly contribute to aggravating the condition or compromise homeostasis. Thus, further studies involving skeletal muscle, adipose, bone, and liver tissue as endocrine organs are essential to better understand the modulation of organokines involved in the pathogenesis of NASH to advance in the treatment of this disease.
C1 [dos Santos, Joao Paulo Margiotti; de Maio, Mariana Canevari] Fac Med Marilia FAMEMA, Sch Med, Ave Monte Carmelo 800, BR-17519030 Marilia, SP, Brazil.
   [Lemes, Monike Alves; Laurindo, Lucas Fornari; Haber, Jesselina Francisco dos Santos; Bechara, Marcelo Dib; Flato, Uri Adrian Prync; Barbalho, Sandra Maria] Univ Marilia UNIMAR, Sch Med, Ave Hygino Muzzy Filho 1001, BR-17525902 Marilia, SP, Brazil.
   [Haber, Jesselina Francisco dos Santos; Chagas, Eduardo Federighi Baisi; Barbalho, Sandra Maria] Interdisciplinary Ctr Diabet CENID UNIMAR Marilia, BR-17525902 Marilia, SP, Brazil.
   [do Prado, Pedro Sidnei] Hosp Israelita Albert Einstein, Intens Care Unit, BR-05652900 Morumbi, SP, Brazil.
   [do Prado, Pedro Sidnei; Costa, Fernando; Pereira, Barbara Cristina de Abreu; Flato, Uri Adrian Prync] Samaritano Hosp, Intens Care Unit, Amer Serv Med, BR-01232010 Sao Paulo, SP, Brazil.
   [Rauen, Eduardo Costa] Rauen Inst, BR-05670000 Sao Paulo, SP, Brazil.
   [Flato, Uri Adrian Prync; Goulart, Ricardo de Alvares; Chagas, Eduardo Federighi Baisi; Barbalho, Sandra Maria] Postgrad Program Struct & Funct Interact Rehabil, Ave Hygino Muzzy Filho 1001, BR-17525902 Marilia, SP, Brazil.
C3 Faculdade de Medicina de Marilia; Universidade de Marilia; Hospital
   Israelita Albert Einstein
RP Barbalho, SM (corresponding author), Univ Marilia UNIMAR, Sch Med, Ave Hygino Muzzy Filho 1001, BR-17525902 Marilia, SP, Brazil.; Barbalho, SM (corresponding author), Interdisciplinary Ctr Diabet CENID UNIMAR Marilia, BR-17525902 Marilia, SP, Brazil.; Barbalho, SM (corresponding author), Postgrad Program Struct & Funct Interact Rehabil, Ave Hygino Muzzy Filho 1001, BR-17525902 Marilia, SP, Brazil.
EM jpmargiotti95@gmail.com; nana16032009@gmail.com;
   monikealvesx3@gmail.com; lucasffffor@gmail.com;
   haber.jesselina@gmail.com; dib.marcelo1@gmail.com;
   pedro.prado@einstein.br; edurauen@gmail.com;
   fernando.costa@samaritano.com.br; barbara.abreu.pereira@gmail.com;
   uriflato@gmail.com; ricardogoulartmed@hotmail.com; efbchagas@gmail.com;
   smbarbalho@gmail.com
RI Chagas, Eduardo/W-8975-2019; Flato, Uri/AAY-3595-2020; FORNARI LAURINDO,
   LUCAS/AAC-8677-2022; barbalho, sandra/Z-3515-2019
OI FORNARI LAURINDO, LUCAS/0000-0003-3159-0982; barbalho,
   sandra/0000-0002-5035-876X; Prync Flato, Uri Adrian/0000-0002-8381-8830;
   Alves Lemes, Monike/0000-0002-8769-0993; Federigh Baisi Chagas,
   Eduardo/0000-0001-6901-9082
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NR 105
TC 34
Z9 37
U1 1
U2 14
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD JAN
PY 2022
VL 23
IS 1
AR 498
DI 10.3390/ijms23010498
PG 28
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA YH4DM
UT WOS:000743118900001
PM 35008925
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Shrestha, J
   Baek, DJ
   Oh, YS
   Cho, SS
   Ki, SH
   Park, EY
AF Shrestha, Jitendra
   Baek, Dong-Jae
   Oh, Yoon-Sin
   Cho, Sam-Seok
   Ki, Sung-Hwan
   Park, Eun-Young
TI Protective Effect of Cudrania tricuspidata Extract against
   High-Fat Diet Induced Nonalcoholic Fatty Liver Disease through
   Nrf-2/HO-1 Pathway
SO MOLECULES
LA English
DT Article
DE nonalcoholic fatty liver disease; Cudrania tricuspidata; antioxidant;
   nuclear factor; erythroid 2 like 2
ID HEPATIC INSULIN-RESISTANCE; OXIDATIVE STRESS; ROOT BARK; EPIDEMIOLOGY;
   STEATOSIS; OBESITY; MICE; PATHOGENESIS; SUPPRESSION; KAEMPFEROL
AB Nonalcoholic fatty liver disease is the most common chronic disease affecting a wide range of the world's population and associated with obesity-induced metabolic syndrome. It is possibly emerging as a leading cause of life-threatening liver diseases for which a drug with a specific therapeutic target has not been developed yet. Previously, there have been reports on the benefits of Cudrania tricuspidata (CT) for treating obesity and diabetes via regulation of metabolic processes, such as lipogenesis, lipolysis, and inflammation. In this study, we investigated the ameliorative effect of orally administered 0.25% and 0.5% (w/w) CT mixed with high-fat diet (HFD) to C57BL/6J mice for 7 weeks. It was found that body weight, fat mass, hepatic mass, serum glucose level, and liver cholesterol levels were significantly reduced after CT treatment. In CT-treated HFD-fed mice, the mRNA expression levels of hepatic lipogenic and inflammatory cytokine-related genes were markedly reduced, whereas the expression level of epididymal lipogenic genes was increased. The mRNA expression level of beta-oxidation and Nrf-2/HO-1 genes significantly increased in CT-treated obese mice livers. We propose that CT alleviates hepatic steatosis by reducing oxidative stress and inflammation.
C1 [Shrestha, Jitendra; Baek, Dong-Jae; Park, Eun-Young] Mokpo Natl Univ, Coll Pharm, Jeonnam 58554, South Korea.
   [Oh, Yoon-Sin] Eulji Univ, Dept Food & Nutr, Seongnam 13135, South Korea.
   [Cho, Sam-Seok; Ki, Sung-Hwan] Chosun Univ, Coll Pharm, Gwangju 61452, South Korea.
C3 Mokpo National University; Eulji University; Chosun University
RP Park, EY (corresponding author), Mokpo Natl Univ, Coll Pharm, Jeonnam 58554, South Korea.; Ki, SH (corresponding author), Chosun Univ, Coll Pharm, Gwangju 61452, South Korea.
EM shresthasimon2011@mokpo.ac.kr; dbaek@mokpo.ac.kr; ysoh@eulji.ac.kr;
   samseok7@gmail.com; shki@chosun.ac.kr; parkey@mokpo.ac.kr
RI Shrestha, Jitendra/KWU-2275-2024
OI Shrestha, Jitendra/0000-0002-5344-994X; Oh, Yoon
   Sin/0000-0003-3995-4429; Back, Dong Jae/0000-0001-6100-488X
FU Korea Institute of Planning and Evaluation for Technology in Food,
   Agriculture, Forestry and Fisheries (IPET) through the Agri-Bio Industry
   Technology Development Program - Ministry of Agriculture, Food and Rural
   Affairs (MAFRA) [3160075]; Basic Science Research Program through the
   National Research Foundation of Korea (NRF) - Ministry of Science, ICT &
   Future Planning [2020R1A2C1012156]
FX This work was supported by the Korea Institute of Planning and
   Evaluation for Technology in Food, Agriculture, Forestry and Fisheries
   (IPET) through the Agri-Bio Industry Technology Development Program,
   funded by Ministry of Agriculture, Food and Rural Affairs (MAFRA;
   3160075) and Basic Science Research Program through the National
   Research Foundation of Korea (NRF) funded by the Ministry of Science,
   ICT & Future Planning (2020R1A2C1012156).
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NR 46
TC 9
Z9 11
U1 0
U2 7
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1420-3049
J9 MOLECULES
JI Molecules
PD MAY
PY 2021
VL 26
IS 9
AR 2434
DI 10.3390/molecules26092434
PG 16
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA SC5CL
UT WOS:000650688900001
PM 33922045
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Dokumacioglu, E
   Iskender, H
   Yenice, G
   Kapakin, KAT
   Sevim, C
   Hayirli, A
   Saral, S
   Comakli, S
AF Dokumacioglu, E.
   Iskender, H.
   Yenice, G.
   Kapakin, K. A. T.
   Sevim, C.
   Hayirli, A.
   Saral, S.
   Comakli, S.
TI Effects of astaxanthin on biochemical and histopathological parameters
   related to oxidative stress on testes of rats on high fructose regime
SO ANDROLOGIA
LA English
DT Article
DE astaxanthin; fructose; oxidative stress; testes
ID INDUCED INSULIN-RESISTANCE; NITRIC-OXIDE SYNTHASE; HEAT-SHOCK PROTEINS;
   METABOLIC SYNDROME; IN-VITRO; CEREBRAL-ISCHEMIA; MALE-INFERTILITY; MICE;
   DAMAGE; CELLS
AB Astaxanthin (ASX) is a xanthophyll family of hydroxycarotenoids which contains several double bonds. It is produced by Haemococcus pluvialis, a microalgae and possesses antioxidant and anti-inflammatory properties. The aim of this study was to test whether ASX could protect against oxidative damage in the testicular tissues of rats receiving high fructose. The rats (n=24) were randomly divided into two main groups: control and fructose (30%, via drinking water) and then each main group either not supplemented or supplemented with ASX (1mg kg(-1) day(-1), within 0.2ml olive oil) via oral gavage. Data were subjected to two-way ANOVA. High fructose consumption tended to increase testis weight and serum testosterone concentration and decreased testicular tissue glutathione-S-transferase (GST) and superoxide dismutase (SOD) levels, but did not affect testicular tissue malondialdehyde (MDA) concentration. Astaxanthin administration increased testosterone, GST and SOD levels and testis weight and decreased MDA concentration. However, ASX administration did not reverse alterations in antioxidant parameters caused by high fructose consumption. Inducible nitric oxide synthase (iNOS) tended to increase in sertoli cell, spermatid and spermatogonia, but not in spermatocytes and leydig cell in response to high fructose consumption. Astaxanthin administration tended to reverse elevation in iNOS in testis cells. In conclusion, ASX could help alleviate oxidative damage caused by high fructose consumption.
C1 [Dokumacioglu, E.; Iskender, H.] Artvin Coruh Univ, Fac Hlth Sci, Dept Nutr & Dietet, Artvin, Turkey.
   [Yenice, G.; Hayirli, A.] Ataturk Univ, Dept Anim Nutr & Nutr Disorders, Fac Vet Med, Erzurum, Turkey.
   [Kapakin, K. A. T.; Comakli, S.] Ataturk Univ, Dept Pathol, Fac Vet Med, Erzurum, Turkey.
   [Sevim, C.] Ataturk Univ, Dept Pharmacol, Fac Vet Med, Erzurum, Turkey.
   [Saral, S.] Recep Tayyip Erdogan Univ, Dept Physiol, Fac Med, Rize, Turkey.
C3 Artvin Coruh University; Ataturk University; Ataturk University; Ataturk
   University; Recep Tayyip Erdogan University
RP Dokumacioglu, E (corresponding author), Artvin Coruh Univ, Fac Hlth Sci, Dept Nutr & Dietet, Artvin, Turkey.
EM edadokumacioglu@yahoo.com
RI DOKUMACIOĞLU, EDA/AAL-5167-2021; Iskender, Hatice/AGW-3701-2022; YENICE,
   Guler/ACS-8619-2022; Sevim, Çiğdem/JED-7015-2023; Saral,
   Sinan/AAE-1125-2022
OI Yenice, Guler/0000-0003-0819-8843; Saral, Sinan/0000-0002-0961-1903;
   COMAKLI, Selim/0000-0002-8744-7686; SEVIM, CIGDEM/0000-0002-0575-3090;
   Dokumacioglu, Eda/0000-0002-2223-1331
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NR 61
TC 25
Z9 26
U1 0
U2 23
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0303-4569
EI 1439-0272
J9 ANDROLOGIA
JI Andrologia
PD SEP
PY 2018
VL 50
IS 7
AR e13042
DI 10.1111/and.13042
PG 10
WC Andrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA GP1AD
UT WOS:000440543900009
PM 29744903
DA 2025-06-11
ER

PT J
AU Mehta, R
   Jeiran, K
   Koenig, AB
   Otgonsuren, M
   Goodman, Z
   Baranova, A
   Younossi, Z
AF Mehta, Rohini
   Jeiran, Kianoush
   Koenig, Aaron B.
   Otgonsuren, Munkzhul
   Goodman, Zachary
   Baranova, Ancha
   Younossi, Zobair
TI The role of mitochondrial genomics in patients with non-alcoholic
   steatohepatitis (NASH)
SO BMC MEDICAL GENETICS
LA English
DT Article
DE PNPLA3 rs738409; Hepatic fibrosis; Obesity; Ethnicity
ID FATTY LIVER-DISEASE; DOMAIN-CONTAINING 3; PNPLA3 I148M RS738409;
   HISTOLOGICAL SEVERITY; OXIDATIVE STRESS; OBESE-PATIENTS; UNITED-STATES;
   DNA VARIATION; SUSCEPTIBILITY; VARIANT
AB Visceral obesity and metabolic syndrome are commonly associated with non-alcoholic fatty liver disease (NAFLD). The progression of steatosis to NASH depends on a number of metabolic and patient-related factors. The mechanisms of genetic predisposition towards the development of NASH and related fibrosis remain unclear. In this study, our aim was to utilize mitotyping and identify mitochondrial haplotypes that may be associated with NAFLD.
   Methods: We examined mitochondrial haplotypes along with patatin-like phospholipase domain containing 3 (PNPLA3) rs738409 genotype to determine their association with NAFLD phenotypes. Whole blood samples were obtained from 341 patients (BMI > 35) undergoing weight reduction surgery after written consent. Liver biopsies were centrally reviewed by a single pathologist based on predetermined pathologic protocol (41.9 % Non-NASH NAFLD, 30.4 % NASH, 27.5 % controls). A 1,122 bp of the mitochondrial control loop was sequenced for each sample and classified into haplogroups.
   Results: The presence of haplogroup L exhibits protection against the development of NASH and pericellular fibrosis. The alleles of PNPLA3 locus showed differential distribution in cohorts with NAFLD, NASH and pericellular fibrosis. Heterozygosity at this locus is independently associated with higher risk of having NASH and pericellular fibrosis.
   Conclusion: Mitochondrial genetics play an important role in NASH probably by modulation of oxidative stress and the efficiency of oxidative phosphorylation.
C1 [Mehta, Rohini; Koenig, Aaron B.; Otgonsuren, Munkzhul; Goodman, Zachary; Younossi, Zobair] Betty & Guy Beatty Ctr Integrated Res, Inova Fairfax Med Campus, Falls Church, VA 22042 USA.
   [Jeiran, Kianoush; Baranova, Ancha] George Mason Univ, Ctr Study Chron Metab & Rare Dis, Fairfax, VA 22033 USA.
   [Younossi, Zobair] Claude Moore Ctr Res & Educ, Betty & Guy Beatty Ctr Integrated Res, 3300 Gallows Rd, Fairfax, VA 22033 USA.
C3 Inova Fairfax Hospital; George Mason University
RP Younossi, Z (corresponding author), Betty & Guy Beatty Ctr Integrated Res, Inova Fairfax Med Campus, Falls Church, VA 22042 USA.; Younossi, Z (corresponding author), Claude Moore Ctr Res & Educ, Betty & Guy Beatty Ctr Integrated Res, 3300 Gallows Rd, Fairfax, VA 22033 USA.
EM Zobair.younossi@inova.org
RI Younossi, Zobair M./JRY-9916-2023; Baranova, Ancha/B-4608-2012
OI Jeiran, Kianoush/0000-0002-0901-034X; Koenig, Aaron/0000-0002-2721-9454;
   Baranova, Ancha/0000-0001-6810-5982
FU Beatty Liver and Obesity Fund at Inova Health System, Falls Church, VA;
   Liver Disease Outcomes Fund of the Center for Liver Diseases at Inova
   Fairfax Hospital, Falls Church, VA
FX This study has been supported by the Beatty Liver and Obesity Fund at
   Inova Health System and the Liver Disease Outcomes Fund of the Center
   for Liver Diseases at Inova Fairfax Hospital, Falls Church, VA.
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NR 56
TC 21
Z9 23
U1 0
U2 8
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1471-2350
J9 BMC MED GENET
JI BMC Med. Genet.
PD SEP 5
PY 2016
VL 17
AR 63
DI 10.1186/s12881-016-0324-0
PG 11
WC Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Genetics & Heredity
GA DW0MW
UT WOS:000383335500001
PM 27596100
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Chin, KY
   Ekeuku, SO
   Chew, DCH
   Trias, A
AF Chin, Kok-Yong
   Ekeuku, Sophia Ogechi
   Chew, Deborah Chia Hsin
   Trias, Anne
TI Tocotrienol in the Management of Nonalcoholic Fatty Liver Disease: A
   Systematic Review
SO NUTRIENTS
LA English
DT Review
DE hepatitis; metabolic disorders; steatosis; steatohepatitis; vitamin E
ID NF-KAPPA-B; DELTA-TOCOTRIENOL; METABOLIC SYNDROME; VITAMIN-E;
   ANTIINFLAMMATORY A20; HEPATIC STEATOSIS; OXIDATIVE STRESS;
   SUPPLEMENTATION; INFLAMMATION; ALPHA
AB The increasing burden of nonalcoholic fatty liver disease (NAFLD) requires innovative management strategies, but an effective pharmacological agent has yet to be found. Apart from weight loss and lifestyle adjustments, one isomer of the vitamin E family-alpha-tocopherol-is currently recommended for nondiabetic steatohepatitis patients. Another member of the vitamin E family, tocotrienol (T3), has anti-inflammatory and antioxidant properties that reach beyond those of alpha-tocopherol, making it a potential agent for use in NAFLD management. This systematic review aimed to provide an overview of the effects of T3 supplementation on NAFLD from both clinical and preclinical perspectives. A literature search was performed in October 2022 using PubMed, Scopus and Web of Science. Original research articles reporting NAFLD outcomes were included in this review. The search located 12 articles (8 animal studies and 4 human studies). The literature reports state that T3 isomers or natural mixtures (derived from palm or annatto) improved NAFLD outcomes (liver histology, ultrasound or liver profile). However, the improvement depended on the severity of NAFLD, study period and type of intervention (isomers/mixture of different compositions). Mechanistically, T3 improved lipid metabolism and prevented liver steatosis, and reduced mitochondrial and endoplasmic reticulum stress, inflammation and ultimately liver fibrosis. In summary, T3 could be a potential agent for use in managing NAFLD, pending more comprehensive preclinical and human studies.
C1 [Chin, Kok-Yong; Ekeuku, Sophia Ogechi] Univ Kebangsaan Malaysia, Fac Med, Dept Pharmacol, Kuala Lumpur 56000, Malaysia.
   [Chew, Deborah Chia Hsin] Univ Kebangsaan Malaysia, Fac Med, Dept Med, Kuala Lumpur 56000, Malaysia.
   [Trias, Anne] Amer River Nutr, Hadley, MA 01035 USA.
C3 Universiti Kebangsaan Malaysia; Universiti Kebangsaan Malaysia
RP Chin, KY (corresponding author), Univ Kebangsaan Malaysia, Fac Med, Dept Pharmacol, Kuala Lumpur 56000, Malaysia.
EM chinkokyong@ppukm.ukm.edu.my
RI Chin, Kok-Yong/B-6309-2015; /ABI-7123-2020
OI Chin, Kok-Yong/0000-0001-6628-1552; /0000-0002-5485-4592
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NR 85
TC 4
Z9 4
U1 1
U2 6
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD FEB
PY 2023
VL 15
IS 4
AR 834
DI 10.3390/nu15040834
PG 17
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 9K7JJ
UT WOS:000941039400001
PM 36839192
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Ungurianu, A
   Zanfirescu, A
   Nitulescu, G
   Margina, D
AF Ungurianu, Anca
   Zanfirescu, Anca
   Nitulescu, Georgiana
   Margina, Denisa
TI Vitamin E beyond Its Antioxidant Label
SO ANTIOXIDANTS
LA English
DT Review
DE tocopherols; tocotrienols; inflammation; cancer
ID NF-KAPPA-B; TOCOTRIENOL-RICH FRACTION; E DELTA-TOCOTRIENOL;
   GAMMA-TOCOPHEROL SUPPLEMENTATION; POLYCYSTIC-OVARY-SYNDROME; C-REACTIVE
   PROTEIN; ALPHA-TOCOPHEROL; OXIDATIVE STRESS; PROSTATE-CANCER;
   ALZHEIMER-DISEASE
AB Vitamin E, comprising tocopherols and tocotrienols, is mainly known as an antioxidant. The aim of this review is to summarize the molecular mechanisms and signaling pathways linked to inflammation and malignancy modulated by its vitamers. Preclinical reports highlighted a myriad of cellular effects like modulating the synthesis of pro-inflammatory molecules and oxidative stress response, inhibiting the NF-kappa B pathway, regulating cell cycle, and apoptosis. Furthermore, animal-based models have shown that these molecules affect the activity of various enzymes and signaling pathways, such as MAPK, PI3K/Akt/mTOR, JAK/STAT, and NF-kappa B, acting as the underlying mechanisms of their reported anti-inflammatory, neuroprotective, and anti-cancer effects. In clinical settings, not all of these were proven, with reports varying considerably. Nonetheless, vitamin E was shown to improve redox and inflammatory status in healthy, diabetic, and metabolic syndrome subjects. The anti-cancer effects were inconsistent, with both pro- and anti-malignant being reported. Regarding its neuroprotective properties, several studies have shown protective effects suggesting vitamin E as a potential prevention and therapeutic (as adjuvant) tool. However, source and dosage greatly influence the observed effects, with bioavailability seemingly a key factor in obtaining the preferred outcome. We conclude that this group of molecules presents exciting potential for the prevention and treatment of diseases with an inflammatory, redox, or malignant component.
C1 [Ungurianu, Anca; Margina, Denisa] Carol Davila Univ Med & Pharm, Dept Biochem, Fac Pharm, Traian Vuia 6, Bucharest 020956, Romania.
   [Zanfirescu, Anca] Carol Davila Univ Med & Pharm, Dept Pharmacol & Clin Pharm, Fac Pharm, Traian Vuia 6, Bucharest 020956, Romania.
   [Nitulescu, Georgiana] Carol Davila Univ Med & Pharm, Dept Pharmaceut Technol, Fac Pharm, Traian Vuia 6, Bucharest 020956, Romania.
C3 Carol Davila University of Medicine & Pharmacy; Carol Davila University
   of Medicine & Pharmacy; Carol Davila University of Medicine & Pharmacy
RP Margina, D (corresponding author), Carol Davila Univ Med & Pharm, Dept Biochem, Fac Pharm, Traian Vuia 6, Bucharest 020956, Romania.
EM anca.ungurianu@umfcd.ro; anca.zanfirescu@umfcd.ro;
   georgiana.nitulescu@umfcd.ro; denisa.margina@umfcd.ro
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NR 213
TC 71
Z9 72
U1 2
U2 34
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD MAY
PY 2021
VL 10
IS 5
AR 634
DI 10.3390/antiox10050634
PG 37
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA SG4DC
UT WOS:000653389300001
PM 33919211
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Shih, DP
   Lin, PY
   Liang, WM
   Tseng, PC
   Kuo, HW
   Wang, JY
AF Shih, Dann-Pyng
   Lin, Ping-Yi
   Liang, Wen-Miin
   Tseng, Po-Chang
   Kuo, Hsien-Wen
   Wang, Jong-Yi
TI Sleep Duration and Effort-Reward Imbalance (ERI) Associated with Obesity
   and Type II Diabetes Mellitus (T2DM) among Taiwanese Middle-Aged Public
   Servants
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Article
DE sleep duration; job strain; obesity; type 2 diabetes mellitus (T2DM)
ID RISK-FACTOR; METABOLIC SYNDROME; QUALITY; STRESS; PREVALENCE; CHEMICALS;
   HEALTH
AB (1) Limited evidence has shown the mediating effects of work characteristics and sleep duration on obesity and type 2 diabetes mellitus (T2DM) among adults. The objective of this study is to assess the interaction effects between sleep duration and effort-reward imbalance (ERI) on the risk of obesity and T2DM among Taiwanese public servants aged 40-60. (2) A national survey for Taiwanese public servants was conducted by multistage stratified random cluster sampling based on proportional probabilistic sampling. A total of 11,875 participants aged 40-60 years old were collected; (3) 3.6% of participants had self-reporting T2DM diagnosed by a physician and the prevalence of overweight and obesity were 44.0% and 15.8%, respectively. There was a significant correlation between sleep hours for the workday and risk of T2DM in non-obese and obese groups (odds ratio, OR = 1.48 and 1.39, respectively), but this did not exist for the weekend/vacation group. Similar trends in the two groups by sleep hours on a workday, obesity and overweight were significantly associated with the risks of T2DM. Clearly, sleep duration and ERI were moderating factors on the association between BMI and on the prevalence of T2DM. (4) A short sleep duration and heavy job stress contributes to the risk of weight gain and T2DM development.
C1 [Shih, Dann-Pyng] China Med Univ, Dept Publ Hlth, Taichung 40402, Taiwan.
   [Shih, Dann-Pyng] Changhua Christian Hosp, Ctr Teaching Excellence, Changhua 50006, Taiwan.
   [Lin, Ping-Yi] Changhua Christian Hosp, Transplant Med & Surg Res Ctr, Changhua 50006, Taiwan.
   [Lin, Ping-Yi] China Med Univ Hosp, Dept Med Res, Taichung 40447, Taiwan.
   [Liang, Wen-Miin; Wang, Jong-Yi] China Med Univ, Dept Hlth Serv Adm, Taichung 40402, Taiwan.
   [Tseng, Po-Chang] Minist Hlth & Welf, Hlth Promot Adm, Taipei 10341, Taiwan.
   [Tseng, Po-Chang; Kuo, Hsien-Wen] Natl Yang Ming Univ, Inst Environm & Occupat Hlth Sci, Taipei 11221, Taiwan.
   [Kuo, Hsien-Wen] Natl Def Med Ctr, Sch Publ Hlth, Taipei 11490, Taiwan.
C3 China Medical University Taiwan; Changhua Christian Hospital; Changhua
   Christian Hospital; China Medical University Taiwan; China Medical
   University Hospital - Taiwan; China Medical University Taiwan; National
   Yang Ming Chiao Tung University; National Defense Medical Center
RP Wang, JY (corresponding author), China Med Univ, Dept Hlth Serv Adm, Taichung 40402, Taiwan.; Kuo, HW (corresponding author), Natl Yang Ming Univ, Inst Environm & Occupat Hlth Sci, Taipei 11221, Taiwan.; Kuo, HW (corresponding author), Natl Def Med Ctr, Sch Publ Hlth, Taipei 11490, Taiwan.
EM 90930@cch.org.tw; 69221@cch.org.tw; wmliang@mail.cmu.edu.tw;
   pochang@hpa.gov.tw; hwkuo@ym.edu.tw; ericwang@mail.cmu.edu.tw
OI Kuo, Hsien-Wen/0000-0003-4184-4333
FU Tobacco Health and Welfare Surcharge, Health Promotion Administration,
   Ministry of Health and Welfare, Executive Yuan, Taiwan, ROC (Civil
   servants health survey program) [2016/B1050406]; China Medical
   University [CMU109-MF-119, CMU108-S-17, CMU108-MF-103]; China Medical
   University Hospital [DMR-109-188, DMR-109-192]; Ministry of Science and
   Technology, Taiwan [MOST108-2410-H-039-001]
FX This study was supported by funding from Tobacco Health and Welfare
   Surcharge, Health Promotion Administration, Ministry of Health and
   Welfare, Executive Yuan, Taiwan, ROC (Civil servants health survey
   program 2016/B1050406), the China Medical University (CMU109-MF-119,
   CMU108-S-17 and CMU108-MF-103), China Medical University Hospital
   (DMR-109-188 and DMR-109-192) and Ministry of Science and Technology,
   Taiwan (Grant no. MOST108-2410-H-039-001).
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NR 37
TC 6
Z9 6
U1 2
U2 12
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD SEP
PY 2020
VL 17
IS 18
AR 6577
DI 10.3390/ijerph17186577
PG 12
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA OE6YM
UT WOS:000580673900001
PM 32917013
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Kösem, A
   Tokmak, A
   Bodur, S
   Aksoy, RT
   Topcuoglu, C
   Turhan, T
   Tasci, Y
AF Kosem, Arzu
   Tokmak, Aytekin
   Bodur, Serkan
   Aksoy, Rifat Taner
   Topcuoglu, Canan
   Turhan, Turan
   Tasci, Yasemin
TI Association of oxidative stress marker ischemia modified albumin and
   polycystic ovary syndrome in adolescent and young girls
SO TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
LA English
DT Article
DE Adolescent medicine; Biomarkers; Cardiovascular diseases; Inflammation;
   Insulin resistance
ID C-REACTIVE PROTEIN; INFLAMMATORY MARKERS; INSULIN-RESISTANCE; METABOLIC
   SYNDROME; LYMPHOCYTE RATIO; NEUTROPHIL; MORTALITY; BINDING; WOMEN; OBESE
AB Objective: The pathophysiologic features of polycystic ovary syndrome (PCOS) seem to be a combination of genetic predisposition and environmental factors. However, data regarding the exact effect of oxidative stress on PCOS is conflicting. This cross sectional and case-control study was designed to compare the serum ischemia modified albumin (IMA) levels in adolescent and young girls with and without PCOS.
   Methods: A total of 41 non-obese adolescents and young girls (15-21 years) diagnosed as PCOS and 41 age and body mass index (BMI) matched controls were enrolled to study. The main features of PCOS and markers of chronic inflammation were determined together with serum IMA levels at the time of study enrollment.
   Results: The C-reactive protein and neutrophil-to-lymphocyte ratio were within the normal ranges and also there were no significant difference between the two groups (p >0.05). Serum levels of IMA were significantly increased in adolescents with PCOS respect to healthy controls (0.44 +/- 0.12 versus 0.35 +/- 0.10 absorbance units, p <0.001). And also there was a significant positive correlation between serum IMA and BMI in all groups (r = 0.274, p = 0.013).
   Conclusion: Serum IMA levels were higher in PCOS patients than in the healthy controls. This elevation may contribute to the increased cardiovascular diseases risk in PCOS patients.
C1 [Tokmak, Aytekin; Aksoy, Rifat Taner; Tasci, Yasemin] Univ Hlth Sci, Zekai Tahir Burak Womens Hlth Res & Educ Hosp, Dept Obstet & Gynecol, Talatpasa Blvd, TR-06230 Ankara, Turkey.
   [Kosem, Arzu; Topcuoglu, Canan; Turhan, Turan] Univ Hlth Sci, Ankara Numune Training & Res Hosp, Dept Clin Biochem, Ankara, Turkey.
   [Bodur, Serkan] Univ Hlth Sci, Gulhane Training & Res Hosp, Dept Obstet & Gynecol, Ankara, Turkey.
C3 University of Health Sciences Turkey; Dr. Zekai Tahir Burak Women's
   Health Research & Education Hospital; University of Health Sciences
   Turkey; Ankara Numune Training & Research Hospital; Gulhane Training &
   Research Hospital; University of Health Sciences Turkey
RP Tokmak, A (corresponding author), Univ Hlth Sci, Zekai Tahir Burak Womens Hlth Res & Educ Hosp, Dept Obstet & Gynecol, Talatpasa Blvd, TR-06230 Ankara, Turkey.
EM arzukosem@gmail.com; aytekintokmak@gmail.com; drserkanbodur@gmail.com;
   aksoytaner@hotmail.com; drcanantopcuoglu@gmail.com;
   drturanturhan@gmail.com; yytasci@yahoo.com
RI tasci, yasemin/AAA-9445-2021; turhan, turan/CAH-5850-2022; aksoy, Rifat
   taner/GWN-0486-2022; Tokmak, Aytekin/K-8296-2016
OI Tasci, Yasemin/0000-0002-6612-7042; Tokmak, Aytekin/0000-0001-5739-5689;
   Topcuoglu, Canan/0000-0002-2058-9380; Aksoy, Rifat
   Taner/0000-0003-3931-4835
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NR 35
TC 2
Z9 2
U1 0
U2 8
PU WALTER DE GRUYTER GMBH
PI BERLIN
PA GENTHINER STRASSE 13, D-10785 BERLIN, GERMANY
SN 0250-4685
EI 1303-829X
J9 TURK J BIOCHEM
JI Turk. J. Biochem.
PD APR
PY 2019
VL 44
IS 2
BP 161
EP 169
DI 10.1515/tjb-2018-0088
PG 9
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA IF7RF
UT WOS:000473280800007
OA gold
DA 2025-06-11
ER

PT J
AU Naviaux, RK
AF Naviaux, Robert K.
TI Antipurinergic therapy for autism-An in-depth review
SO MITOCHONDRION
LA English
DT Review
DE Ml mitochondria; M2 mitochondria; Purinergic signaling; Cell danger
   response; Ecogenetics; Ecoalleles; Epigenetics; Metabolism; Nucleotides;
   Antipurinergic therapy; Suramin
ID BRILLIANT BLUE G; SPECTRUM DISORDER; EXTRACELLULAR ATP; OXIDATIVE
   STRESS; MITOCHONDRIAL-DNA; P2 RECEPTORS; DEVELOPMENTAL DISORDERS;
   METABOLIC FEATURES; MENTAL-RETARDATION; PURINE METABOLISM
AB Are the symptoms of autism caused by a treatable metabolic syndrome that traces to the abnormal persistence of a normal, alternative functional state of mitochondria? A small clinical trial published in 2017 suggests this is possible. Based on a new unifying theory of pathogenesis for autism called the cell danger response (CDR) hypothesis, this study of 10 boys, ages 5-14 years, showed that all 5 boys who received antipurinergic therapy (APT) with a single intravenous dose of suramin experienced improvements in all the core symptoms of autism that lasted for 5-8 weeks. Language, social interaction, restricted interests, and repetitive movements all improved. Two children who were non-verbal spoke their first sentences. None of these improvements were observed in the placebo group. Larger and longer studies are needed to confirm this promising discovery. This review introduces the concept of M2 (anti-inflammatory) and M1 (pro-inflammatory) mitochondria that are polarized along a functional continuum according to cell stress. The pathophysiology of the CDR, the complementary functions of M1 and M2 mitochondria, relevant gene-environment interactions, and the metabolic underpinnings of behavior are discussed as foundation stones for understanding the improvements in ASD behaviors produced by antipurinergic therapy in this small clinical trial.
C1 [Naviaux, Robert K.] Univ Calif San Diego, Sch Med, 214 Dickinson St,Bldg CTF,Rm C102,MC 8467, San Diego, CA 92103 USA.
C3 University of California System; University of California San Diego
RP Naviaux, RK (corresponding author), Univ Calif San Diego, Sch Med, 214 Dickinson St,Bldg CTF,Rm C102,MC 8467, San Diego, CA 92103 USA.
EM Naviaux@ucsd.edu
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NR 219
TC 24
Z9 28
U1 0
U2 12
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1567-7249
EI 1872-8278
J9 MITOCHONDRION
JI Mitochondrion
PD NOV
PY 2018
VL 43
SI SI
BP 1
EP 15
DI 10.1016/j.mito.2017.12.007
PG 15
WC Cell Biology; Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Cell Biology; Genetics & Heredity
GA HD1CG
UT WOS:000452246100001
PM 29253638
OA hybrid
DA 2025-06-11
ER

PT J
AU Whon, TW
   Shin, NR
   Jung, MJ
   Hyun, DW
   Kim, HS
   Kim, PS
   Bae, JW
AF Whon, Tae Woong
   Shin, Na-Ri
   Jung, Mi-Ja
   Hyun, Dong-Wook
   Kim, Hyun Sik
   Kim, Pil Soo
   Bae, Jin-Woo
TI Conditionally Pathogenic Gut Microbes Promote Larval Growth by
   Increasing Redox-Dependent Fat Storage in High-Sugar Diet-Fed
   Drosophila
SO ANTIOXIDANTS & REDOX SIGNALING
LA English
DT Article
DE bacterial uracil; Drosophila melanogaster; gut microbiota; high-sugar
   diet; redox signaling; symbiotic relationship
ID INNATE IMMUNE HOMEOSTASIS; OXIDATIVE STRESS; INSULIN-RESISTANCE;
   HOLOGENOME THEORY; ADIPOSE-TISSUE; LIFE-SPAN; OBESITY; INFECTION; HOST;
   ROS
AB Aims: Changes in the composition of the gut microbiota contribute to the development of obesity and subsequent complications that are associated with metabolic syndrome. However, the role of increased numbers of certain bacterial species during the progress of obesity and factor(s) controlling the community structure of gut microbiota remain unclear. Here, we demonstrate the inter-relationship between Drosophila melanogaster and their resident gut microbiota under chronic high-sugar diet (HSD) conditions.
   Results: Chronic feeding of an HSD to Drosophila resulted in a predominance of resident uracil-secreting bacteria in the gut. Axenic insects mono-associated with uracil-secreting bacteria or supplemented with uracil under HSD conditions promoted larval development. Redox signaling induced by bacterial uracil promoted larval growth by regulating sugar and lipid metabolism via activation of p38a mitogen-activated protein kinase.
   Innovation: The present study identified a new redox-dependent mechanism by which uracil-secreting bacteria (previously regarded as opportunistic pathobionts) protect the host from metabolic perturbation under chronic HSD conditions.
   Conclusion: These results illustrate how Drosophila and gut microbes form a symbiotic relationship under stress conditions, and changes in the gut microbiota play an important role in alleviating deleterious diet-derived effects such as hyperglycemia. Antioxid. Redox Signal. 27, 1361-1380.
C1 [Bae, Jin-Woo] Kyung Hee Univ, Dept Life & Nanopharmaceut Sci, Seoul 130701, South Korea.
   [Bae, Jin-Woo] Kyung Hee Univ, Dept Biol, Seoul 130701, South Korea.
C3 Kyung Hee University; Kyung Hee University
RP Bae, JW (corresponding author), Kyung Hee Univ, Dept Life & Nanopharmaceut Sci, Seoul 130701, South Korea.; Bae, JW (corresponding author), Kyung Hee Univ, Dept Biol, Seoul 130701, South Korea.
EM baejw@khu.ac.kr
RI Kim, Pil/AAM-8478-2021; Bae, Jin-Woo/S-1955-2017
OI Bae, Jin-Woo/0000-0001-6433-5270
FU Mid-career Researcher Program [NRF-2016R1E1A1A02921587]; National
   Research Foundation of Korea (NRF) - Ministry of Science ICT and Future
   Planning [2015M3C9A2054299]; NRF - Ministry of Education
   [2015R1D1A4A01019390]
FX The authors thank Dr. W.-J. Lee and Dr. S.-H. Kim (Seoul National
   University) for help with in vivo experiments, and for providing the fly
   stocks. They also thank Dr. S. Hyun (ChungAng University, Seoul,
   Republic of Korea), Dr. K.S. Cho (Konkuk University), Dr. W. Sullivan
   (University of California, Santa Cruz, CA), Dr. B. Lemaitre (EPFL,
   Lausanne, Switzerland), Dr. E. Owusu-Ansah (Columbia University College
   of Physicians & Surgeons, New York, NY), Dr. D. Bohmann (University of
   Rochester), Dr. E. Hafen (ETH Zurich, Zurich, Switzerland), and Dr. S.
   Ishii (RIKEN Tsukuba Institute, Ibaraki, Japan) for providing fly
   stocks. This work is supported by the Mid-career Researcher Program
   (NRF-2016R1E1A1A02921587 to J.-W.B.) and the Collaborative Genome
   Program for Fostering New Post-Genome industry (2015M3C9A2054299 to
   J.-W.B.) through the National Research Foundation of Korea (NRF) funded
   by the Ministry of Science ICT and Future Planning, and the Basic
   Science Research Program (2015R1D1A4A01019390 to T.W.W.) through the NRF
   funded by the Ministry of Education.
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NR 81
TC 13
Z9 15
U1 1
U2 58
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1523-0864
EI 1557-7716
J9 ANTIOXID REDOX SIGN
JI Antioxid. Redox Signal.
PD DEC 1
PY 2017
VL 27
IS 16
BP 1361
EP 1380
DI 10.1089/ars.2016.6790
PG 20
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA FK1XF
UT WOS:000413276200007
PM 28462587
DA 2025-06-11
ER

PT J
AU Vijaykrishnaraj, M
   Wang, KW
AF Vijaykrishnaraj, M.
   Wang, Kuiwu
TI Dietary natural products as a potential inhibitor towards advanced
   glycation end products and hyperglycemic complications: A phytotherapy
   approaches
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Review
DE Natural products; Flavonoids; Glycation; Hyperglycemia; AGEs &
   inhibitors
ID TYPE-2 DIABETES-MELLITUS; OXIDATIVE STRESS; ALPHA-GLUCOSIDASE;
   DOUBLE-BLIND; IN-VITRO; SIMULTANEOUS EXTRACTION; CARDIOMETABOLIC RISK;
   ASSISTED EXTRACTION; INSULIN-RESISTANCE; ESSENTIAL OIL
AB Natural products exist in various natural foods such as plants, herbs, fruits, and vegetables. Furthermore, marine life offers potential natural products with significant biological activity. The biochemical reaction is known as advanced glycation end products (AGEs) occurs in the human body. On the other hand, foods are capable of a wide range of processing conditions resulting in the generation of exogenous AGEs adducts. Protein glycation and the formation of advanced glycation end products both contribute to the pathogenesis of hyperglycemic complications. AGEs also play a pivotal role in microvascular and macrovascular complications progression by receptors for advanced glycation end products (RAGE). RAGE activate by AGEs leads to up-regulation of transcriptional factor NF-kB and inflammatory genes. Around the globe, researchers are working in various approaches for therapeutical implications on controlling AGEs mediated disease complications. In this regard, one of the potential promising agents observed with a wide range of AGEs inhibition by food-derived natural products. Current biotechnological tools have been turned to natural products or phytochemicals to manufacture the molecules without compromising their functionality. Metabolic engineering and bioinformatics perspectives have recently enabled the generation of a few potent metabolites with anti-diabetic activity. As the primary focus, this review article will also discuss multidisciplinary approaches that emphasize current advances in antidiabetic therapeutic action and future perspectives of natural products.
C1 [Vijaykrishnaraj, M.; Wang, Kuiwu] Zhejiang Gongshang Univ, Sch Food Sci & Biotechnol, Hangzhou 310018, Peoples R China.
C3 Zhejiang Gongshang University
RP Wang, KW (corresponding author), Zhejiang Gongshang Univ, Sch Food Sci & Biotechnol, Hangzhou 310018, Peoples R China.
EM vijay.bdu@gmail.com; wkwnpc@mail.zjgsu.edu.cn
RI Sasthri, Vijaykrishnaraj/AAS-5812-2020
FU Jiangsu Key Laboratory of Regional Resource Exploitation and Medicinal
   Research, PR China [LPRK201801]
FX The corresponding author thanks the open fund of Jiangsu Key Laboratory
   of Regional Resource Exploitation and Medicinal Research (LPRK201801),
   PR China.
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NR 144
TC 32
Z9 33
U1 4
U2 81
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD DEC
PY 2021
VL 144
AR 112336
DI 10.1016/j.biopha.2021.112336
EA OCT 2021
PG 16
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA WO6XK
UT WOS:000712594700008
PM 34678719
OA gold
DA 2025-06-11
ER

PT J
AU Costache, DO
   Bejan, H
   Poenaru, M
   Costache, RS
AF Costache, Daniel Octavian
   Bejan, Horia
   Poenaru, Marcela
   Costache, Raluca Simona
TI Skin Cancer Correlations in Psoriatic Patients
SO CANCERS
LA English
DT Review
DE psoriasis; skin cancer; treatment
ID POPULATION-BASED COHORT; CHRONIC PLAQUE PSORIASIS;
   NECROSIS-FACTOR-ALPHA; EPIDERMAL T-CELLS; LONG-TERM SAFETY;
   MALIGNANT-MELANOMA; ARTHRITIS PATIENTS; SQUAMOUS-CELL; FOLLOW-UP;
   HELICOBACTER-PYLORI
AB Psoriasis is a common chronic, immune-mediated, inflammatory disease with associated comorbidities. Common psoriasis-associated comorbidities include psoriatic arthritis, cardiovascular disease, metabolic syndrome, inflammatory digestive syndromes, and depression. A less studied association is between psoriasis and specific-site cancers. A key cell in the pathophysiology of psoriasis is the myeloid dendritic cell, which links the innate and adaptive immune systems, and therefore is involved in the control of cancer-prevention mechanisms. The relationship between cancer and inflammation is not new, with inflammation being recognized as a key element in the development of neoplastic foci. Infection leads to the development of local chronic inflammation, which further leads to the accumulation of inflammatory cells. Various phagocytes produce reactive oxygen species that cause mutations in cellular DNA and lead to the perpetuation of cells with altered genomes. Therefore, in inflammatory sites, there will be a multiplication of cells with damaged DNA, leading to tumor cells. Over the years, scientists have tried to assess the extent to which psoriasis can increase the risk of developing skin cancer. Our aim is to review the available data and present some information that might help both the patients and the care providers in properly managing psoriatic patients to prevent skin cancer development.
C1 [Costache, Daniel Octavian] Carol Davila Univ Med & Pharm, Fac Med, Dermatol Discipline 2, Bucharest 050474, Romania.
   [Bejan, Horia] Carol Davila Univ Med & Pharm, Fac Med, Bucharest 050474, Romania.
   [Poenaru, Marcela] Carol Davila Univ Cent Emergency Mil Hosp, Dermatol Dept, Bucharest 010825, Romania.
   [Costache, Raluca Simona] Carol Davila Univ Med & Pharm, Fac Med, Internal Med & Gastroenterol Discipline, Bucharest 050474, Romania.
C3 Carol Davila University of Medicine & Pharmacy; Carol Davila University
   of Medicine & Pharmacy; Carol Davila University of Medicine & Pharmacy
RP Bejan, H (corresponding author), Carol Davila Univ Med & Pharm, Fac Med, Bucharest 050474, Romania.; Costache, RS (corresponding author), Carol Davila Univ Med & Pharm, Fac Med, Internal Med & Gastroenterol Discipline, Bucharest 050474, Romania.
EM daniel.costache@umfcd.ro; bejanhoria@yahoo.com;
   marcelapoenaru@yahoo.com; raluca.costache@umfcd.ro
RI Costache, Raluca/L-9259-2019; Costache, Daniel Octavian/L-9257-2019
OI Costache, Raluca Simona/0000-0002-0381-5550; Costache, Daniel
   Octavian/0000-0002-5906-8654
FU University of Medicine and Pharmacy Carol Davila, through the
   institutional program Publish not Perish
FX This research received no external funding and the APC was funded by the
   University of Medicine and Pharmacy Carol Davila, through the
   institutional program Publish not Perish.
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NR 97
TC 12
Z9 12
U1 1
U2 1
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2072-6694
J9 CANCERS
JI Cancers
PD APR 25
PY 2023
VL 15
IS 9
AR 2451
DI 10.3390/cancers15092451
PG 13
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA G1ZO4
UT WOS:000987224800001
PM 37173917
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Mirhashemi, ME
   Shah, RV
   Kitchen, RR
   Rong, J
   Spahillari, A
   Pico, AR
   Vitseva, O
   Levy, D
   Demarco, D
   Shah, S
   Iafrati, MD
   Larson, MG
   Tanriverdi, K
   Freedman, JE
AF Mirhashemi, Marzieh Ezzaty
   Shah, Ravi, V
   Kitchen, Robert R.
   Rong, Jian
   Spahillari, Aferdita
   Pico, Alexander R.
   Vitseva, Olga
   Levy, Daniel
   Demarco, Danielle
   Shah, Sajani
   Iafrati, Mark D.
   Larson, Martin G.
   Tanriverdi, Kahraman
   Freedman, Jane E.
TI The Dynamic Platelet Transcriptome in Obesity and Weight Loss
SO ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
LA English
DT Article
DE cardiovascular disease; gene expression; obesity; platelet;
   transcriptome
ID CARDIOVASCULAR-DISEASE; GENE-EXPRESSION; INFLAMMATION; ACTIVATION;
   CANCER; LIVER; RISK; PCR
AB Objective:
   Adiposity is associated with oxidative stress, inflammation, and glucose intolerance. Previous data suggest that platelet gene expression is associated with key cardiometabolic phenotypes, including body mass index but stable in healthy individuals over time. However, modulation of gene expression in platelets in response to metabolic shifts (eg, weight reduction) is unknown and may be important to defining mechanism.
   Approach and Results:
   Platelet RNA sequencing and aggregation were performed from 21 individuals with massive weight loss (>45 kg) following bariatric surgery. Based on RNA sequencing data, we measured the expression of 67 genes from isolated platelet RNA using high-throughput quantitative reverse transcription quantitative PCR in 1864 FHS (Framingham Heart Study) participants. Many transcripts not previously studied in platelets were differentially expressed with bariatric surgical weight loss, appeared specific to platelets (eg, not differentially expressed in leukocytes), and were enriched for a nonalcoholic fatty liver disease pathway. Platelet aggregation studies did not detect alteration in platelet function after significant weight loss. Linear regression models demonstrated several platelet genes modestly associated with cross-sectional cardiometabolic phenotypes, including body mass index. There were no associations between studied transcripts and incident diabetes or cardiovascular end points.
   Conclusions:
   In summary, while there is no change in platelet aggregation function after significant weight loss, the human platelet experiences a dramatic transcriptional shift that implicates pathways potentially relevant to improved cardiometabolic risk postweight loss (eg, nonalcoholic fatty liver disease). Further studies are needed to determine the mechanistic importance of these observations.
C1 [Mirhashemi, Marzieh Ezzaty; Vitseva, Olga; Tanriverdi, Kahraman; Freedman, Jane E.] Univ Massachusetts, Sch Med, Dept Med, Div Cardiovasc Med, Worcester, MA 01655 USA.
   [Shah, Ravi, V; Kitchen, Robert R.; Spahillari, Aferdita] Harvard Med Sch, Div Cardiol, Dept Med, Massachusetts Gen Hosp, Boston, MA 02115 USA.
   [Rong, Jian; Larson, Martin G.] Boston Univ, Dept Biostat, Boston, MA 02215 USA.
   [Pico, Alexander R.] Gladstone Inst, Inst Data Sci & Biotechnol, San Francisco, CA USA.
   [Levy, Daniel] Framingham Heart Dis Epidemiol Study, Framingham, MA USA.
   [Levy, Daniel] NHLBI, Populat Sci Branch, NIH, Bldg 10, Bethesda, MD 20892 USA.
   [Demarco, Danielle; Shah, Sajani; Iafrati, Mark D.] Tufts Univ, Dept Surg, Boston, MA USA.
C3 University of Massachusetts System; University of Massachusetts
   Worcester; Harvard University; Harvard Medical School; Harvard
   University Medical Affiliates; Massachusetts General Hospital; Boston
   University; University of California System; University of California
   San Francisco; The J David Gladstone Institutes; Framingham Heart Study;
   National Institutes of Health (NIH) - USA; NIH National Heart Lung &
   Blood Institute (NHLBI); Tufts University
RP Mirhashemi, ME (corresponding author), Univ Massachusetts, Sch Med, Albert Sherman Ctr, 368 Plantat St,AS7-1012, Worcester, MA 01655 USA.
EM marzieh.mirhashemi@umassmed.edu
RI Pico, Alexander/HCH-4305-2022; Levy, Daniel/ABB-2752-2021; Freedman,
   Jane/KLC-3446-2024; Shah, Ravi/KLD-0068-2024
OI Levy, Daniel/0000-0003-1843-8724; Mirhashemi,
   Marzieh/0000-0002-9497-2155; Freedman, Jane/0000-0002-0011-6164; Pico,
   Alexander/0000-0001-5706-2163; Kitchen, Robert/0000-0003-1443-8559;
   Shah, Ravi/0000-0002-4471-7156
FU National Heart, Lung, and Blood Institute (NHLBI) [U54HL112311,
   U01HL126495]; FHS (Framingham Heart Study; NHLBI/National Institutes of
   Health [NIH]) [HHSN268201500001I]; NIH [N01-HC-25195]; American Heart
   Association [SFRN31740000]; Mathers Foundation Award
FX This work was supported by U54HL112311 and U01HL126495 (J.E. Freedman,
   K. Tanriverdi) and from National Heart, Lung, and Blood Institute
   (NHLBI), FHS (Framingham Heart Study; NHLBI/National Institutes of
   Health [NIH] contract No. HHSN268201500001I). The FHS is funded by NIH
   contract N01-HC-25195. This work was also funded from the American Heart
   Association (grant SFRN31740000; J.E. Freedman, M. Ezzaty Mirhashemi)
   and a Mathers Foundation Award (J.E. Freedman).
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NR 33
TC 20
Z9 22
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1079-5642
EI 1524-4636
J9 ARTERIOSCL THROM VAS
JI Arterioscler. Thromb. Vasc. Biol.
PD FEB
PY 2021
VL 41
IS 2
BP 854
EP 864
DI 10.1161/ATVBAHA.120.315186
PG 11
WC Hematology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Hematology; Cardiovascular System & Cardiology
GA RL9YX
UT WOS:000639320300033
PM 33297754
OA Bronze, Green Accepted
DA 2025-06-11
ER

PT J
AU Chan, CL
AF Chan, Christine L.
TI Use of Continuous Glucose Monitoring in Youth-Onset Type 2 Diabetes
SO CURRENT DIABETES REPORTS
LA English
DT Review
DE Continuous glucose monitoring; Youth-onset type 2 diabetes
ID HEMOGLOBIN A1C; GLYCEMIC VARIABILITY; OXIDATIVE STRESS; INDIVIDUALS;
   ADOLESCENTS; ASSOCIATION; PROFILES; OBESE
AB Purpose of Review Continuous glucose monitoring (CGM) technology has long been accepted as a tool for managing glycemia in type 1 diabetes (T1D) and is receiving increased attention as a tool for monitoring glucose patterns in patients with other forms of diabetes, in particular type 2 diabetes (T2D). Recent studies in adults with T2D have shown benefits of CGMin the investigation of glycemic variability, as well as utility as a tool for improving glycemic control. The literature on CGM use in youth-onset T2D, however, is sparse. This paper reviews the various roles for CGMin T2D, with a focus on published reports of CGM use in youth-onset T2D. The gaps in knowledge are highlighted, along with a discussion regarding need for future studies of potential applications for CGM in this younger population.
   Recent Findings CGM systems provide insight into glycemic abnormalities in obese youth with and at risk for T2D. This technology has enabled examination of the relationship between free-living glycemic profiles and traditional diabetes screening tests, as well as markers of cardiometabolic risk in this high-risk population.
   Summary Investigators are incorporating CGM technology into the study of T2D in youth, but interventional studies of CGM as a tool for glycemic control in youth-onset T2D are limited. Youth with T2D face a more aggressive disease than adults with T2D, and further studies utilizing advances in glucose monitoring technology to improve outcomes in this population are needed.
C1 [Chan, Christine L.] Univ Colorado, Sch Med, Childrens Hosp Colorado, Dept Pediat,Endocrinol, 13123 E 16th Ave, Aurora, CO 80045 USA.
C3 University of Colorado System; University of Colorado Anschutz Medical
   Campus; Children's Hospital Colorado
RP Chan, CL (corresponding author), Univ Colorado, Sch Med, Childrens Hosp Colorado, Dept Pediat,Endocrinol, 13123 E 16th Ave, Aurora, CO 80045 USA.
EM Christinel.chan@childrenscolorado.org
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NR 41
TC 15
Z9 15
U1 0
U2 11
PU CURRENT MEDICINE GROUP
PI PHILADELPHIA
PA 400 MARKET STREET, STE 700, PHILADELPHIA, PA 19106 USA
SN 1534-4827
EI 1539-0829
J9 CURR DIABETES REP
JI Curr. Diabetes Rep.
PD SEP
PY 2017
VL 17
IS 9
AR 66
DI 10.1007/s11892-017-0905-0
PG 5
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA FD3QM
UT WOS:000407447500001
PM 28726154
DA 2025-06-11
ER

PT J
AU Tsamou, M
   Kremers, FAC
   Samaritakis, KA
   Roggen, EL
AF Tsamou, Maria
   Kremers, Fabienne A. C.
   Samaritakis, Keano A.
   Roggen, Erwin L.
TI Identifying microRNAs Possibly Implicated in Myalgic
   Encephalomyelitis/Chronic Fatigue Syndrome and Fibromyalgia: A Review
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE miRNA; chronic fatigue syndrome; fibromyalgia; chronic pain; chronic
   disease
ID TOLL-LIKE RECEPTORS; SEX-DIFFERENCES; CHRONIC PAIN; KAPPA-B; NITROSATIVE
   STRESS; METABOLIC SYNDROME; GENE-EXPRESSION; UP-REGULATION; MECHANISMS;
   PREVALENCE
AB Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and fibromyalgia (FM) are chronic syndromes of unknown etiology, accompanied by numerous symptoms affecting neurological and physical conditions. Despite frequent revisions of the diagnostic criteria, clinical practice guidelines are often outdated, leading to underdiagnosis and ineffective treatment. Our aim was to identify microRNA (miRNA) biomarkers implicated in pathological mechanisms underlying these diseases. A comprehensive literature review using publicly accessible databases was conducted. Interesting miRNAs were extracted from relevant publications on ME/CFS and/or FM, and were then linked to pathophysiological processes possibly manifesting these chronic diseases. Dysregulated miRNAs in ME/CFS and FM may serve as promising biomarkers for these diseases. Key identified miRNAs, such as miR-29c, miR-99b, miR-128, miR-374b, and miR-766, were frequently mentioned for their roles in immune response, mitochondrial dysfunction, oxidative stress, and central sensitization, while miR-23a, miR-103, miR-152, and miR-320 were implicated in multiple crucial pathological processes for FM and/or ME/CFS. In summary, both ME/CFS and FM seem to share many dysregulated biological or molecular processes, which may contribute to their commonly shared symptoms. This miRNA-based approach offers new angles for discovering molecular markers urgently needed for early diagnosis or therapeutics to tackle the pathology of these medically unexplained chronic diseases.
C1 [Tsamou, Maria; Kremers, Fabienne A. C.; Samaritakis, Keano A.; Roggen, Erwin L.] ToxGenSolutions TGS, NL-6229 EV Maastricht, Netherlands.
RP Tsamou, M (corresponding author), ToxGenSolutions TGS, NL-6229 EV Maastricht, Netherlands.
EM maria.tsamou@toxgen.solutions; fabienne.kremers@toxgen.solutions;
   keano.samaritakis@toxgen.solutions; erwin.roggen@toxgen.solutions
OI Tsamou, Maria/0000-0002-1315-3909; /0000-0002-6338-1918
FU ToxGenSolutions BV; The 3Rs Management and Consulting ApS
FX This research was funded by ToxGenSolutions BV and 3Rs Management and
   Consulting ApS (https://3rsmc-aps.com (accessed on 1 August 2024)).
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NR 182
TC 2
Z9 2
U1 3
U2 5
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD SEP
PY 2024
VL 25
IS 17
AR 9551
DI 10.3390/ijms25179551
PG 17
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA F6N0U
UT WOS:001310955000001
PM 39273498
OA gold
DA 2025-06-11
ER

PT J
AU Okeke, ES
   Nweze, EJ
   Anaduaka, EG
   Okoye, CO
   Anosike, CA
   Joshua, PE
   Ezeorba, TPC
AF Okeke, Emmanuel Sunday
   Nweze, Ekene John
   Anaduaka, Emeka Godwin
   Okoye, Charles Obinwanne
   Anosike, Chioma Assumpta
   Joshua, Parker Elijah
   Ezeorba, Timothy Prince Chidike
TI Plant-derived nanomaterials (PDNM): a review on pharmacological
   potentials against pathogenic microbes, antimicrobial resistance (AMR)
   and some metabolic diseases
SO 3 BIOTECH
LA English
DT Review
DE Plant-derived nanomaterials (PDNMs); Metabolic diseases; Green
   nanoparticles; Antimicrobial resistance (AMR); Drug delivery
ID GREEN SILVER NANOPARTICLES; DRUG-DELIVERY-SYSTEMS; LEAF EXTRACT;
   IN-VITRO; SYNTHESIZED SILVER; OXIDATIVE STRESS; ANTIPLASMODIAL ACTIVITY;
   ANTIBACTERIAL ACTIVITY; ANTIDIABETIC ACTIVITY; LIPID NANOPARTICLES
AB Plant-derived nanomaterials (PDNM) have gained significant attention recently due to their potential pharmacological applications against pathogenic microbes, antimicrobial resistance (AMR), and certain metabolic diseases. This review introduces the concept of PDNMs and their unique properties, including their small size, high surface area, and ability to penetrate biological barriers. Besides various methods for synthesizing PDNMs, such as green synthesis techniques that utilize plant extracts and natural compounds, the advantages of using plant-derived materials, such as their biocompatibility, biodegradability, and low toxicity, were elucidated. In addition, it examines the recent and emerging trends in nanomaterials derived from plant approaches to combat antimicrobial resistance and metabolic diseases. The sizes of nanomaterials and their surface areas are vital as they play essential roles in the interactions and relationships between these materials and the biological components or organization. We critically analyze the biomedical applications of nanoparticles which include antibacterial composites for implantable devices and nanosystems to combat antimicrobial resistance, enhance antibiotic delivery, and improve microbial diagnostic/detection systemsIn addition, plant extracts can potentially interfere with metabolic syndrome pathways; hence most nano-formulations can reduce chronic inflammation, insulin resistance, oxidative stress, lipid profile, and antimicrobial resistance. As a result, these innovative plant-based nanosystems may be a promising contender for various pharmacological applications.
C1 [Okeke, Emmanuel Sunday; Nweze, Ekene John; Anaduaka, Emeka Godwin; Anosike, Chioma Assumpta; Joshua, Parker Elijah; Ezeorba, Timothy Prince Chidike] Univ Nigeria, Fac Biol Sci, Dept Biochem, Nsukka 410001, Enugu, Nigeria.
   [Okeke, Emmanuel Sunday] Univ Nigeria, Sch Gen Studies, Nat Sci Unit, Nsukka 410001, Enugu, Nigeria.
   [Okeke, Emmanuel Sunday] Jiangsu Univ, Sch Environm & Safety Engn, Inst Environm Hlth & Ecol Secur, Zhenjiang 212013, Jiangsu, Peoples R China.
   [Okoye, Charles Obinwanne] Jiangsu Univ, Sch Environm & Safety Engn, Zhenjiang 212013, Peoples R China.
   [Okoye, Charles Obinwanne] Univ Nigeria, Dept Zool & Environm Biol, Nsukka 410001, Enugu, Nigeria.
   [Okoye, Charles Obinwanne] Jiangsu Univ, Biofuels Inst, Zhenjiang 212013, Peoples R China.
   [Anaduaka, Emeka Godwin; Joshua, Parker Elijah; Ezeorba, Timothy Prince Chidike] Univ Nigeria, Fac Biol Sci, Dept Genet & Biotechnol, Nsukka 410001, Enugu, Nigeria.
   [Ezeorba, Timothy Prince Chidike] Univ Birmingham Edgbaston, Coll Life & Environm Sci, Dept Environm Hlth & Risk Management, Birmingham B15 2TT, England.
C3 University of Nigeria; University of Nigeria; Jiangsu University;
   Jiangsu University; University of Nigeria; Jiangsu University;
   University of Nigeria; University of Birmingham
RP Ezeorba, TPC (corresponding author), Univ Nigeria, Fac Biol Sci, Dept Biochem, Nsukka 410001, Enugu, Nigeria.; Ezeorba, TPC (corresponding author), Univ Nigeria, Fac Biol Sci, Dept Genet & Biotechnol, Nsukka 410001, Enugu, Nigeria.; Ezeorba, TPC (corresponding author), Univ Birmingham Edgbaston, Coll Life & Environm Sci, Dept Environm Hlth & Risk Management, Birmingham B15 2TT, England.
EM timothy.ezeorba@unn.edu.ng
RI Okeke, Emmanuel/AAD-4496-2021; Ezeorba, Timothy/GPK-5534-2022; Okoye,
   Charles/AAZ-4484-2021
OI Ezeorba, Timothy/0000-0002-7077-3282
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NR 176
TC 6
Z9 6
U1 0
U2 9
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 2190-572X
EI 2190-5738
J9 3 BIOTECH
JI 3 Biotech
PD SEP
PY 2023
VL 13
IS 9
AR 291
DI 10.1007/s13205-023-03713-w
PG 25
WC Biotechnology & Applied Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology
GA O3UC8
UT WOS:001043091500001
PM 37547919
OA Green Published, hybrid
DA 2025-06-11
ER

PT S
AU Dai, DF
   Chiao, YA
   Martin, GM
   Marcinek, DJ
   Basisty, N
   Quarles, EK
   Rabinovitch, PS
AF Dai, D. -F.
   Chiao, Y. -A.
   Martin, G. M.
   Marcinek, D. J.
   Basisty, N.
   Quarles, E. K.
   Rabinovitch, P. S.
BE Reddy, PH
TI Mitochondrial-Targeted Catalase: Extended Longevity and the Roles in
   Various Disease Models
SO MOLECULAR BIOLOGY OF AGING
SE Progress in Molecular Biology and Translational Science
LA English
DT Review; Book Chapter
ID INDUCED OXIDATIVE STRESS; INDUCED HEART-FAILURE; ELEGANS LIFE-SPAN;
   ALZHEIMERS-DISEASE; SKELETAL-MUSCLE; PLASTOQUINONE DERIVATIVES;
   INTERRUPT EXECUTION; PARKINSONS-DISEASE; MOUSE MODEL;
   SUPEROXIDE-DISMUTASE
AB The free-radical theory of aging was proposed more than 50 years ago. As one of the most popular mechanisms explaining the aging process, it has been extensively studied in several model organisms. However, the results remain controversial. The mitochondrial version of free-radical theory of aging proposes that mitochondria are both the primary sources of reactive oxygen species (ROS) and the primary targets of ROS-induced damage. One critical ROS is hydrogen peroxide, which is naturally degraded by catalase in peroxisomes or glutathione peroxidase within mitochondria. Our laboratory developed mice-overexpressing catalase targeted to mitochondria (mCAT), peroxisomes (pCAT), or the nucleus (nCAT) in order to investigate the role of hydrogen peroxide in different subcellular compartments in aging and age-related diseases. The mCAT mice have demonstrated the largest effects on life span and healthspan extension. This chapter will discuss the mCAT phenotype and review studies using mCAT to investigate the roles of mitochondrial oxidative stresses in various disease models, including metabolic syndrome and atherosclerosis, cardiac aging, heart failure, skeletal muscle pathology, sensory defect, neurodegenerative diseases, and cancer. As ROS has been increasingly recognized as essential signaling molecules that may be beneficial in hormesis, stress response and immunity, the potential pleiotropic, or adverse effects of mCAT are also discussed. Finally, the development of small-molecule mitochondrial-targeted therapeutic approaches is reviewed.
C1 [Dai, D. -F.; Chiao, Y. -A.; Martin, G. M.; Marcinek, D. J.; Basisty, N.; Quarles, E. K.; Rabinovitch, P. S.] Univ Washington, Seattle, WA 98195 USA.
C3 University of Washington; University of Washington Seattle
RP Rabinovitch, PS (corresponding author), Univ Washington, Seattle, WA 98195 USA.
EM PeterR@medicine.washington.edu
RI Quarles, Ellen/V-1712-2019; Basisty, Nathan/J-9294-2014; Martin,
   George/HKP-2081-2023; Dai, Dao-Fu/AAM-4396-2021
OI Quarles, Ellen/0000-0002-7160-3939; Dai, Dao-Fu/0000-0001-7724-321X
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NR 201
TC 52
Z9 59
U1 1
U2 17
PU ELSEVIER ACADEMIC PRESS INC
PI SAN DIEGO
PA 525 B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495 USA
SN 1877-1173
BN 978-0-12-811532-9
J9 PROG MOL BIOL TRANSL
JI Prog. Molec. Biol. Transl. Sci.
PY 2017
VL 146
BP 203
EP 241
DI 10.1016/bs.pmbts.2016.12.015
PG 39
WC Biochemistry & Molecular Biology; Geriatrics & Gerontology
WE Book Citation Index – Science (BKCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Geriatrics & Gerontology
GA BL5NL
UT WOS:000452370400009
PM 28253986
DA 2025-06-11
ER

PT J
AU Hattori, S
   Kamiya, T
   Hara, H
   Ninomiya, M
   Koketsu, M
   Adachi, T
AF Hattori, Shuhei
   Kamiya, Tetsuro
   Hara, Hirokazu
   Ninomiya, Masayuki
   Koketsu, Mamoru
   Adachi, Tetsuo
TI CoCl2 Decreases EC-SOD Expression through Histone
   Deacetylation in COS7 Cells
SO BIOLOGICAL & PHARMACEUTICAL BULLETIN
LA English
DT Article
DE extracellular-superoxide dismutase (EC-SOD); epigenetic; hypoxia;
   luteolin
ID EXTRACELLULAR-SUPEROXIDE DISMUTASE; ACTIVATED PROTEIN-KINASE; ER STRESS
   INDUCER; OXIDATIVE STRESS; ENDOPLASMIC-RETICULUM; EPIGENETIC REGULATION;
   METABOLIC SYNDROME; MESSENGER-RNA; GENE; METHYLATION
AB Extracellular-superoxide dismutase (EC-SOD), one of the SOD isozymes, is negatively regulated under hypoxic conditions, and decreases in its expression may exacerbate vascular diseases. Moreover, epigenetics, such as DNA methylation and histone modifications, are known to play a critical role in the progression of cancer, type 2 diabetes, and atherosclerosis. We previously investigated the involvement of reactive oxygen species (ROS) and p38 mitogen-activated protein kinase (MAPK) in decreases in EC-SOD expression in hypoxic COS7 cells; however, the role of epigenetics in this process currently remains unknown. In the present study, we demonstrated that the hypoxia mimetic cobalt chloride (CoCl2) decreased histone acetylation levels, and a pretreatment with 4-phenyl butyric acid (PBA), an inhibitor of histone deacetylase, significantly suppressed CoCl2-elicited histone deacetylation and decreases in EC-SOD. We found that CoCl2-elicited decreases in EC-SOD were accompanied by reductions in histone H3 acetylation levels within its promoter region. Furthermore, luteolin, a well-known flavonoid, significantly suppressed the CoCl2-elicited accumulation of ROS, p38-MAPK activation, and histone deacetylation. Collectively, the results of the present study showed for the first time that CoCl2 decreases the expression of EC-SOD through its deacetylation and luteolin may be one of the seed compounds that maintain redox homeostasis, even under hypoxic conditions.
C1 [Hattori, Shuhei; Kamiya, Tetsuro; Hara, Hirokazu; Adachi, Tetsuo] Gifu Pharmaceut Univ, Lab Clin Pharmaceut, 1-25-4 Daigaku Nishi, Gifu 5011196, Japan.
   [Ninomiya, Masayuki; Koketsu, Mamoru] Gifu Univ, Fac Engn, Dept Chem & Biomol Sci, 1-1 Yanagido, Gifu 5011193, Japan.
C3 Gifu Pharmaceutical University; Gifu University
RP Kamiya, T (corresponding author), Gifu Pharmaceut Univ, Lab Clin Pharmaceut, 1-25-4 Daigaku Nishi, Gifu 5011196, Japan.
EM tekamiya@gifu-pu.ac.jp
RI Kamiya, Tetsuro/AAY-7093-2021
FU Japan Society for the Promotion for Science [26460070]; Gifu
   Pharmaceutical University; Grants-in-Aid for Scientific Research
   [26460070] Funding Source: KAKEN
FX This study was supported in part by a Grant-in-Aid for Scientific
   Research from the Japan Society for the Promotion for Science (T.K., No.
   26460070) and a Grant for the encouragement of young scientists from
   Gifu Pharmaceutical University (T.K.).
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NR 51
TC 4
Z9 4
U1 0
U2 5
PU PHARMACEUTICAL SOC JAPAN
PI TOKYO
PA 2-12-15 SHIBUYA, SHIBUYA-KU, TOKYO, 150-0002, JAPAN
SN 0918-6158
J9 BIOL PHARM BULL
JI Biol. Pharm. Bull.
PD DEC
PY 2016
VL 39
IS 12
BP 2036
EP 2041
DI 10.1248/bpb.b16-00551
PG 6
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA ED7DA
UT WOS:000389014700017
PM 27904046
OA gold
DA 2025-06-11
ER

PT J
AU Hu, YY
   Zhao, Y
   Ren, DY
   Guo, JJ
   Luo, YY
   Yang, XB
AF Hu, Yuanyuan
   Zhao, Yan
   Ren, Daoyuan
   Guo, Jianjun
   Luo, Yiyang
   Yang, Xingbin
TI Hypoglycemic and hepatoprotective effects of
   D-chiro-inositol-enriched tartary buckwheat extract in high
   fructose-fed mice
SO FOOD & FUNCTION
LA English
DT Article
ID INDUCED INSULIN-RESISTANCE; OXIDATIVE STRESS; CHEMICAL-COMPOSITION;
   METABOLIC SYNDROME; SERUM GLUCOSE; RICH EXTRACT; ANTIOXIDANT;
   DYSFUNCTION; PROTEIN; RATS
AB This study was designed to investigate the protective effects of D-Chiro-Inositol (DCI) enriched tartary buckwheat extract (DTBE) against high fructose (HF) diet-induced hyperglycemia and liver injury in mice. HPLC analysis revealed that the content of DCI present in purified DTBE was 34.06%. Mice fed 20% fructose in drinking water for 8 weeks significantly displayed hyperglycemia, hyperinsulinemia, dyslipidemia, hepatic steatosis and oxidative stress (p < 0.01). Continuous administration of DTBE in HF-fed mice dose-dependently reduced the HF-induced elevation of body weight, serum glucose, insulin, total cholesterol (TC), total triglycerides (TG) and low density lipoprotein cholesterol (LDL-C) levels, as well as serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), C-reactive protein (CRP) and lactate dehydrogenase (LDH) activities, while the HF-induced decline of serum high density lipoprotein-cholesterol (HDL-C) levels could be markedly elevated in the mice. Meanwhile, DTBE also dose-dependently increased the hepatic total superoxide dismutase (T-SOD) and glutathione peroxidase (GSH-Px) activities, and decreased hepatic malonaldehyde (MDA) levels, relative to HF-treated mice. Histopathology of H&E and Oil Red O staining confirmed liver injury induced by a HF diet and the hepatoprotective effect of DTBE. These findings are the first to demonstrate that the intake of DTBE may be a feasible preventive or therapeutic strategy for HF diet-induced hyperglycemia, hepatic steatosis and oxidative injury.
C1 [Hu, Yuanyuan; Ren, Daoyuan; Guo, Jianjun; Luo, Yiyang; Yang, Xingbin] Shaanxi Normal Univ, Key Lab, Minist Educ Med Resource & Nat Pharmaceut Chem, Coll Food Engn & Nutr Sci, Xian 710062, Peoples R China.
   [Zhao, Yan] Fourth Mil Med Univ, Sch Pharm, Xian 710032, Peoples R China.
C3 Shaanxi Normal University; Air Force Medical University
RP Hu, YY (corresponding author), Shaanxi Normal Univ, Key Lab, Minist Educ Med Resource & Nat Pharmaceut Chem, Coll Food Engn & Nutr Sci, Xian 710062, Peoples R China.
EM yanzhao@fmmu.edu.cn; xbyang@snnu.edu.cn
RI Luo, Yiyang/E-3067-2019; hu, yuan/HTL-4197-2023
OI Hu, Yuanyuan/0000-0001-6788-702X
FU National Natural Science Foundation of China [C31171678]; Excellent
   Doctoral Dissertation Funded Projects of Shaanxi Normal University,
   China [X2014YB09]; Fundamental Research Funds for the Central
   Universities of Shaanxi Normal University, China [GK201501006]
FX This study was supported by the grants from the National Natural Science
   Foundation of China (C31171678), and the Excellent Doctoral Dissertation
   Funded Projects of Shaanxi Normal University, China (X2014YB09), and the
   Fundamental Research Funds for the Central Universities of Shaanxi
   Normal University, China (GK201501006).
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NR 36
TC 30
Z9 38
U1 0
U2 72
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PY 2015
VL 6
IS 12
BP 3760
EP 3769
DI 10.1039/c5fo00612k
PG 10
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA CX8AO
UT WOS:000365924300015
PM 26412138
DA 2025-06-11
ER

PT J
AU Rault-Nania, MH
   Demougeot, C
   Gueux, E
   Berthelot, A
   Dzimira, S
   Rayssiguier, Y
   Rock, E
   Mazur, A
AF Rault-Nania, Marie-Helene
   Demougeot, Celine
   Gueux, Elyett
   Berthelot, Alain
   Dzimira, Stanislaw
   Rayssiguier, Yves
   Rock, Edmond
   Mazur, Andrzej
TI Inulin supplementation prevents high fructose diet-induced hypertension
   in rats
SO CLINICAL NUTRITION
LA English
DT Article
DE inulin; oligofructose; Wistar rats; hypertension; oxidative stress
ID INSULIN-RESISTANCE; LIPID-METABOLISM; VASCULAR RELAXATION;
   OLIGOFRUCTOSE; FRUCTANS; ATHEROSCLEROSIS; HEALTH; FIBER
AB Background & aims: The aim of this experiment was to evaluate the potential. beneficial effect of supplementation with different inulin-type fructan fractions against common features of the metabolic syndrome in a rat model. of this syndrome (fructose-fed rat).
   Methods: Forty Wistar rats were randomly divided into five groups and the animals received for 4weeks either a semi-purified starch or fructose-based diet, or diets in which fructose was partially substituted with various fructans: 10 g/100 g of tong-chain inulin or oligofructose, or an oligofructose-enriched inulin. After this period, blood pressure was measured and samples of blood and tissues were collected for selected biochemical. analyses.
   Results: As compared to the starch-fed group, the fructose-fed rats presented: hypertriglyceridemia, hypertension, increased susceptibility to heart peroxidation and renal damages. Long-chain inulin and oligofructose-enriched inulin supplementation prevented fructose induced elevated blood pressure, susceptibility to heart peroxidation and renal damages. All inulin-type fructans containing diets prevented fructose induced hypertriglyceridemia.
   Conclusions: These results suggest that supplementation with inulin-type fructans is efficient against fructose induced hypertension and that effects are most pronounced for tong-chain inulin and oligofructose-enriched inulin. We hypothesize that the anti-hypertensive effect of inulin could be explained by the reduction of the high fructose induced oxidative stress. (c) 2008 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.
C1 [Rault-Nania, Marie-Helene; Gueux, Elyett; Rayssiguier, Yves; Rock, Edmond; Mazur, Andrzej] INRA, Ctr Rech & Nutr Humaine Auvergne, Unite Nutr Humaine, F-63122 St Genes Champanelle, France.
   [Berthelot, Alain] Fac Med Pharm, Lab Physiol Pharmacol Nutr Prevent Expt, Besancon, France.
   [Dzimira, Stanislaw] Wroclaw Univ Environm & Life Sci9, Fac Vet Med, Wroclaw, Poland.
C3 INRAE; Universite de Franche-Comte; Wroclaw University of Environmental
   & Life Sciences
RP Mazur, A (corresponding author), INRA, Ctr Rech & Nutr Humaine Auvergne, Unite Nutr Humaine, Equipe Stress Metab & Micronutriments, F-63122 St Genes Champanelle, France.
EM mazur@clermont.inra.fr
RI Mazur, Andre/AAG-9751-2020; Dzimira, Stanislaw/S-5801-2016
OI Mazur, Andre/0000-0002-1067-5066; Demougeot, Celine/0000-0003-0639-9756;
   Dzimira, Stanislaw/0000-0001-7203-2392
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NR 35
TC 39
Z9 42
U1 2
U2 29
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0261-5614
J9 CLIN NUTR
JI Clin. Nutr.
PD APR
PY 2008
VL 27
IS 2
BP 276
EP 282
DI 10.1016/j.clnu.2008.01.015
PG 7
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 296US
UT WOS:000255571900016
PM 18358572
DA 2025-06-11
ER

PT J
AU Rajasekar, P
   Palanisamy, N
   Anuradha, CV
AF Rajasekar, P.
   Palanisamy, N.
   Anuradha, C. V.
TI Increase in nitric oxide and reductions in blood pressure, protein
   kinase C β II and oxidative stress by L-carnitine:: A study in the
   fructose-fed hypertensive rat
SO CLINICAL AND EXPERIMENTAL HYPERTENSION
LA English
DT Review
DE fructose; blood pressure; PKC beta II; free fatty acid; L-carnitine
ID ANGIOTENSIN-CONVERTING ENZYME; INSULIN-RESISTANCE; RENAL KALLIKREIN;
   DISEASE; PLASMA; INHIBITION; DEFICIENCY; EXPRESSION; MUSCLE; KIDNEY
AB Recently we showed that the administration of intraperitoneal L-carnitine (CA) has insulin-sensitizing effects in the high fructose-fed Wistar rat, a widely used model of metabolic syndrome. The present study was conducted to examine the regulatory effects of CA on blood pressure (BP) and related pressor mechanisms. Fructose-fed rats (FFR) showed elevated BP, cardiac hypertrophy, glucose intolerance, and increases in plasma glucose, insulin, free fatty acids (FFA), and angiotensin-converting enzyme (ACE) activity. They also showed increased protein kinase C beta II (PKC beta IT) expression and oxidative stress in cardiac tissue. In plasma, decreased kallikrein enzyme activity and nitric oxide metabolites were observed, compared to control. Simultaneous treatment with CA (300 mg/Kg) mitigated these alterations. PKC beta II expression was similar to that of control; the rats displayed normal BP and ACE activity, enhanced antioxidant protection, and close to normal values of metabolic parameters. The BP-lowering effect of CA was abolished when CA-treated rats were administered L-nitroarginyl methyl ester (L-NAME 6g/Kg). These observations suggest that the BP-lowering action of CA in this model could be attributed to multiple and interrelated mechanisms, such as an increase in NO and kinin availability, reduction in PKC action, and antioxidant protection.
C1 Annamalai Univ, Dept Biochem & Biotechnol, Fac Sci, Annamalainagar 608002, Tamil Nadu, India.
C3 Annamalai University
RP Anuradha, CV (corresponding author), Annamalai Univ, Dept Biochem & Biotechnol, Fac Sci, Annamalainagar 608002, Tamil Nadu, India.
EM cvaradha@hotmail.com
RI Nallasamy, Palanisamy/AAH-7727-2021; Panchamoorthy,
   Rajasekar/AAF-1555-2020; Venkatraman, Anuradha/U-8717-2019
OI NALLASAMY, PALANISAMY/0000-0001-8962-2487; Carani Venkatraman,
   Anuradha/0000-0001-9924-2533
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NR 45
TC 28
Z9 32
U1 0
U2 1
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1064-1963
EI 1525-6006
J9 CLIN EXP HYPERTENS
JI Clin. Exp. Hypertens.
PD NOV
PY 2007
VL 29
IS 8
BP 517
EP 530
DI 10.1080/10641960701743998
PG 14
WC Pharmacology & Pharmacy; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Cardiovascular System & Cardiology
GA 238KY
UT WOS:000251447700002
PM 18058477
DA 2025-06-11
ER

PT J
AU Toma, L
   Deleanu, M
   Sanda, GM
   Barbalata, T
   Niculescu, LS
   Sima, AV
   Stancu, CS
AF Toma, Laura
   Deleanu, Mariana
   Sanda, Gabriela Maria
   Barbalata, Teodora
   Niculescu, Loredan Stefan
   Sima, Anca Volumnia
   Stancu, Camelia Sorina
TI Bioactive Compounds Formulated in Phytosomes Administered as
   Complementary Therapy for Metabolic Disorders
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE bioactive compounds; cardiovascular diseases; diabetes mellitus;
   dyslipidemia; hepatic disorders; inflammatory stress; metabolic
   disorders; metabolic syndrome; oxidative stress; phytosomes
ID GINKGO-BILOBA PHYTOSOMES; IMPROVING ORAL BIOAVAILABILITY; FATTY
   LIVER-DISEASE; GRAPE SEED EXTRACT; PHOSPHOLIPID COMPLEX; ANTIOXIDANT
   ACTIVITY; OCIMUM-SANCTUM; DRUG-DELIVERY; IN-VITRO; CARDIOPROTECTIVE
   ACTIVITY
AB Metabolic disorders (MDs), including dyslipidemia, non-alcoholic fatty liver disease, diabetes mellitus, obesity and cardiovascular diseases are a significant threat to human health, despite the many therapies developed for their treatment. Different classes of bioactive compounds, such as polyphenols, flavonoids, alkaloids, and triterpenes have shown therapeutic potential in ameliorating various disorders. Most of these compounds present low bioavailability when administered orally, being rapidly metabolized in the digestive tract and liver which makes their metabolites less effective. Moreover, some of the bioactive compounds cannot fully exert their beneficial properties due to the low solubility and complex chemical structure which impede the passive diffusion through the intestinal cell membranes. To overcome these limitations, an innovative delivery system of phytosomes was developed. This review aims to highlight the scientific evidence proving the enhanced therapeutic benefits of the bioactive compounds formulated in phytosomes compared to the free compounds. The existing knowledge concerning the phytosomes' preparation, their characterization and bioavailability as well as the commercially available phytosomes with therapeutic potential to alleviate MDs are concisely depicted. This review brings arguments to encourage the use of phytosome formulation to diminish risk factors inducing MDs, or to treat the already installed diseases as complementary therapy to allopathic medication.
C1 [Toma, Laura; Deleanu, Mariana; Sanda, Gabriela Maria; Barbalata, Teodora; Niculescu, Loredan Stefan; Sima, Anca Volumnia; Stancu, Camelia Sorina] Romanian Acad, Inst Cellular Biol & Pathol Nicolae Simionescu, 8 BP Hasdeu St, Bucharest 050568, Romania.
C3 Romanian Academy; Nicolae Simionescu Institute of Cellular Biology &
   Pathology
RP Stancu, CS (corresponding author), Romanian Acad, Inst Cellular Biol & Pathol Nicolae Simionescu, 8 BP Hasdeu St, Bucharest 050568, Romania.
EM laura.toma@icbp.ro; mariana.deleanu@icbp.ro; gabriela.sanda@icbp.ro;
   teodora.barbalata@icbp.ro; loredan.niculescu@icbp.ro; anca.sima@icbp.ro;
   camelia.stancu@icbp.ro
RI Stancu, Camelia/C-3882-2011; Deleanu, Mariana/HNI-8946-2023; Toma,
   Laura/AAC-3068-2021; Barbalata, Teodora/GLU-3041-2022; Sanda,
   Gabriela/C-2561-2011; Niculescu, Loredan/F-2591-2010; Sima,
   Anca/C-3904-2011
OI Stancu, Camelia Sorina/0000-0002-2988-9961
FU Romanian Academy and by the Romanian Ministry of Research, Innovation,
   and Digitization, CNCS/CCCDI-UEFISCDI
FX No Statement Available
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NR 243
TC 9
Z9 9
U1 4
U2 10
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD APR
PY 2024
VL 25
IS 8
AR 4162
DI 10.3390/ijms25084162
PG 40
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA OX2G0
UT WOS:001210505200001
PM 38673748
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Fauste, E
   Rodrigo, S
   Aguirre, R
   Donis, C
   Rodríguez, L
   Alvarez-Millán, JJ
   Panadero, MI
   Otero, P
   Bocos, C
AF Fauste, Elena
   Rodrigo, Silvia
   Aguirre, Rodrigo
   Donis, Cristina
   Rodriguez, Lourdes
   Alvarez-Millan, Juan J.
   Panadero, Maria I.
   Otero, Paola
   Bocos, Carlos
TI Maternal Fructose Intake Increases Liver H2S Synthesis but
   Exarcebates its Fructose-Induced Decrease in Female Progeny
SO MOLECULAR NUTRITION & FOOD RESEARCH
LA English
DT Article; Early Access
DE fetal programming; fructose; hydrogen sulfide; liver; oxidative stress
ID CYSTATHIONINE-GAMMA-LYASE; HIGH-FAT DIET; HYDROGEN-SULFIDE PRODUCTION;
   FOLIC-ACID SUPPLEMENTATION; OXIDATIVE STRESS; RISK-FACTOR; INDUCED
   DYSLIPIDEMIA; SWEETENED BEVERAGES; PLASMA HOMOCYSTEINE;
   ENDOTHELIAL-CELLS
AB Scope: Fructose intake from added sugars correlates with the epidemic rise in metabolic syndrome and cardiovascular diseases (CVD). However, consumption of beverages containing fructose is allowed during gestation. Homocysteine (Hcy) is a well-known risk factor for CVD while hydrogen sulfide (H2S), a product of its metabolism, has been proved to exert opposite effects to Hcy.
   Methods and results: First, it is investigated whether maternal fructose intake produces subsequent changes in Hcy metabolism and H2S synthesis of the progeny. Carbohydrates are supplied to pregnant rats in drinking water (10% wt/vol) throughout gestation. Adult female descendants from fructose-fed, control or glucose-fed mothers are studied. Females from fructose-fed mothers have elevated homocysteinemia, hepatic H2S production, cystathionine gamma-lyase (CSE) (the key enzyme in H2S synthesis) expression and plasma H2S, versus the other two groups. Second, it is studied how adult female progeny from control (C/F), fructose- (F/F), and glucose-fed (G/F) mothers responded to liquid fructose and compared them to the control group (C/C). Interestingly, hepatic CSE expression and H2S synthesis are diminished by fructose intake, this effect being more pronounced in F/F females.
   Conclusion: Maternal fructose intake produces a fetal programming that increases hepatic H2S production and, in contrast, exacerbates its fructose-induced drop in female progeny.
C1 [Fauste, Elena; Rodrigo, Silvia; Aguirre, Rodrigo; Donis, Cristina; Rodriguez, Lourdes; Panadero, Maria I.; Otero, Paola; Bocos, Carlos] Univ San Pablo CEU, Fac Farm, CEU Univ, Madrid 28668, Spain.
   [Alvarez-Millan, Juan J.] CQS Lab, 7 Rivas Vaciamadrid, Madrid 28521, Spain.
C3 San Pablo CEU University
RP Bocos, C (corresponding author), Univ San Pablo CEU, Fac Farm, CEU Univ, Madrid 28668, Spain.
EM carbocos@ceu.es
RI Fauste, Elena/AAT-8282-2020; Panadero, Maribel/L-4262-2017; Donis,
   Cristina/ABF-9806-2020; Otero, Paola/H-9150-2015; BOCOS,
   CARLOS/B-8460-2015
OI Fauste, Elena/0000-0002-5783-3092; Alvarez Millan, Juan
   Jose/0000-0002-6774-4958; BOCOS, CARLOS/0000-0003-0364-5958
FU Ministerio de Ciencia, Innovacion y Universidades (MICINN)
   [SAF2017-89537-R]; European Community FEDER funds; FUSP-CEU fellowship;
   FPU fellowship from MICINN
FX The authors would like to thank Jose M. Garrido and his team for their
   help in handling the rats, and Brian Crilly for his editorial help. The
   authors also thank CEMBIO, USP-CEU, for the experimental help. This work
   was supported by a grant from Ministerio de Ciencia, Innovacion y
   Universidades (MICINN) (SAF2017-89537-R), and the European Community
   FEDER funds. S.R. was supported with a FUSP-CEU fellowship. E.F. was
   supported with a FPU fellowship from MICINN.
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NR 67
TC 3
Z9 3
U1 0
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1613-4125
EI 1613-4133
J9 MOL NUTR FOOD RES
JI Mol. Nutr. Food Res.
PD 2020 AUG 19
PY 2020
AR 2000628
DI 10.1002/mnfr.202000628
EA AUG 2020
PG 12
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA NB3OI
UT WOS:000560424700001
PM 32754997
DA 2025-06-11
ER

PT J
AU Uchiyama, T
   Itaya-Hironaka, A
   Yamauchi, A
   Makino, M
   Sakuramoto-Tsuchida, S
   Shobatake, R
   Ota, H
   Takeda, M
   Ohbayashi, C
   Takasawa, S
AF Uchiyama, Tomoko
   Itaya-Hironaka, Asako
   Yamauchi, Akiyo
   Makino, Mai
   Sakuramoto-Tsuchida, Sumiyo
   Shobatake, Ryogo
   Ota, Hiroyo
   Takeda, Maiko
   Ohbayashi, Chiho
   Takasawa, Shin
TI Intermittent Hypoxia Up-Regulates CCL2, RETN, and TNF mRNAs in
   Adipocytes via Down-regulation of miR-452
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE adipokine; intermittent hypoxia; microRNA; sleep apnea syndrome
ID OBSTRUCTIVE SLEEP-APNEA; NECROSIS-FACTOR-ALPHA; ADIPONECTIN
   GENE-EXPRESSION; OXIDATIVE STRESS; ADIPOSE-TISSUE; TRANSCRIPTION
   FACTORS; METABOLIC SYNDROME; DIABETES-MELLITUS; INSULIN; 3T3-L1
AB Sleep apnea syndrome (SAS), characterized by recurrent episodes of oxygen desaturation and reoxygenation (intermittent hypoxia [IH]), is a risk factor for insulin resistance. Recently, IH is considered to independently cause adipose tissue inflammation/dysfunction, leading to worsening insulin resistance; however, the detailed mechanism remains unknown. We exposed mouse 3T3-L1 and human SW872 adipocytes to experimental IH or normoxia for 24 h, and analyzed mRNA expression of several adipokines. We found that the mRNA levels of RETN, TNF, and CCL2 in SW872 and 3T3-L1 adipocytes were significantly increased by IH, whereas the promoter activities of these genes were not increased. A target mRNA search of microRNA (miR)s revealed that all human mRNAs have a potential target sequence for miR-452. The miR-452 level of IH-treated cells was significantly decreased compared to normoxia-treated cells. MiR-452 mimic and non-specific control RNA (miR-452 mimic NC) were introduced into SW872 cells, and the IH-induced up-regulation of the genes was abolished by introduction of the miR-452 mimic but not by the miR-452 mimic NC. These results indicate that IH stress down-regulates the miR-452 in adipocytes, resulting in increased levels of RETN, TNF, and CCL2 mRNAs, leading to insulin resistance in SAS patients.
C1 [Uchiyama, Tomoko; Itaya-Hironaka, Asako; Yamauchi, Akiyo; Makino, Mai; Sakuramoto-Tsuchida, Sumiyo; Shobatake, Ryogo; Ota, Hiroyo; Takasawa, Shin] Nara Med Univ, Dept Biochem, 840 Shijo Cho, Kashihara, Nara 6348521, Japan.
   [Uchiyama, Tomoko; Takeda, Maiko; Ohbayashi, Chiho] Nara Med Univ, Dept Diagnost Pathol, 840 Shijo Cho, Kashihara, Nara 6348522, Japan.
   [Ota, Hiroyo] Nara Med Univ, Dept Internal Med 2, 840 Shijo Cho, Kashihara, Nara 6348522, Japan.
   [Takeda, Maiko] Natl Hosp Org Kinki Chuo Chest Med Ctr, Dept Lab Med & Pathol, Kita Ku, 1180 Nagasone Cho, Sakai, Osaka 5918025, Japan.
C3 Nara Medical University; Nara Medical University; Nara Medical
   University
RP Takasawa, S (corresponding author), Nara Med Univ, Dept Biochem, 840 Shijo Cho, Kashihara, Nara 6348521, Japan.
EM uchiyama0403@naramed-u.ac.jp; iasako@naramed-u.ac.jp;
   yamauchi@naramed-u.ac.jp; m.makino@naramed-u.ac.jp;
   ssumiyo@naramed-u.ac.jp; rshobatake@naramed-u.ac.jp;
   hiroyon@naramed-u.ac.jp; maikot@naramed-u.ac.jp;
   ohbayashi@naramed-u.ac.jp; shintksw@naramed-u.ac.jp
OI Takasawa, Shin/0000-0002-4066-0199; Shobatake, Ryogo/0000-0002-4165-1200
FU JSPS KAKENHI [JP18K15067]; Ministry of Education, Culture, Sports,
   Science, and Technology (JSPS), Japan
FX This work was supported in part by JSPS KAKENHI Grant Number JP18K15067,
   Grants-in-Aid for Young Scientists from the Ministry of Education,
   Culture, Sports, Science, and Technology (JSPS), Japan.
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NR 74
TC 43
Z9 46
U1 0
U2 2
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD APR 2
PY 2019
VL 20
IS 8
AR 1960
DI 10.3390/ijms20081960
PG 16
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA HX8ID
UT WOS:000467648700158
PM 31013606
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Gill, JM
   Saligan, L
   Lee, H
   Rotolo, S
   Szanton, S
AF Gill, Jessica M.
   Saligan, Leorey
   Lee, Henna
   Rotolo, Susan
   Szanton, Sarah
TI Women in recovery from PTSD have similar inflammation and quality of
   life as non-traumatized controls
SO JOURNAL OF PSYCHOSOMATIC RESEARCH
LA English
DT Article
DE Health; Inflammation; Resilience; Trauma; Women
ID POSTTRAUMATIC-STRESS-DISORDER; HEALTH-CARE UTILIZATION; ALPHA-INDUCED
   CHANGES; INTERFERON-ALPHA; METABOLIC SYNDROME; PSYCHOMETRIC PROPERTIES;
   VIETNAM VETERANS; HEART-DISEASE; SYMPTOMS; RISK
AB Objective: Post-traumatic stress disorder (PTSD) is associated with greater concentrations of inflammatory biomarkers as well as substantial medical burden; however, it is not clear if these morbidity risks change following recovery from PTSD. In this study we compare women who have-recovered from PTSD, to those with current PTSD, and healthy controls on their perceived health and inflammatory and metabolic biomarkers.
   Methods: We studied 3 groups of women: those with current PTSD, those who reported recovery from PTSD, and healthy non-traumatized controls, which were determined using standard diagnostic instruments. We obtained a morning blood sample and examined concentrations of inflammatory biomarkers of: interleukin 6 (IL-6) and c-reactive protein (CRP), and lipid concentrations. Lastly, we evaluated health related quality of life (HRQOL).
   Results: Women who had recovered from PTSD had a similar HRQOL and inflammatory biomarkers as non-traumatized controls. Their concentrations of inflammatory biomarkers were lower than women with current PTSD, and similar to non-traumatized controls.
   Conclusion: Health perception as well as biological indicators of health significantly differ in women in recovery from PTSD, compared to those who remain symptomatic. These findings suggest that the psychological recovery is associated with normal levels of inflammatory biomarkers and HRQOL. (C) 2012 Published by Elsevier Inc.
C1 [Gill, Jessica M.; Saligan, Leorey; Lee, Henna] NINR, NIH, Bethesda, MD 20892 USA.
   [Gill, Jessica M.] George Mason Univ, Sch Nursing, Fairfax, VA 22030 USA.
   [Rotolo, Susan] Inova Hlth Serv, Falls Church, VA USA.
   [Szanton, Sarah] Johns Hopkins Univ, Sch Nursing, Baltimore, MD 21218 USA.
C3 National Institutes of Health (NIH) - USA; NIH National Institute of
   Nursing Research (NINR); George Mason University; Johns Hopkins
   University
RP Gill, JM (corresponding author), 10 Ctr Dr, Bethesda, MD 20892 USA.
EM gillj@mail.nih.gov
RI Gill, Gill/Q-2020-2017; Saligan, Leorey/M-7101-2015
OI Saligan, Leorey/0000-0001-9481-7836
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NR 86
TC 59
Z9 67
U1 0
U2 27
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-3999
EI 1879-1360
J9 J PSYCHOSOM RES
JI J. Psychosomat. Res.
PD APR
PY 2013
VL 74
IS 4
BP 301
EP 306
DI 10.1016/j.jpsychores.2012.10.013
PG 6
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 112IT
UT WOS:000316586600006
PM 23497831
DA 2025-06-11
ER

PT J
AU Rombouts, K
   Marra, F
AF Rombouts, Krista
   Marra, Fabio
TI Molecular Mechanisms of Hepatic Fibrosis in Non-Alcoholic
   Steatohepatitis
SO DIGESTIVE DISEASES
LA English
DT Article; Proceedings Paper
CT Falk Workshop on Immunology and Liver Disease/Falk Symposium 171 on
   Liver and Metabolic Syndrome
CY OCT 15-18, 2009
CL Hannover, GERMANY
DE Non-alcoholic steatohepatitis; Hepatic stellate cells; Liver fibrosis;
   Adipokines
ID RENIN-ANGIOTENSIN SYSTEM; FATTY LIVER-DISEASE; FACTOR-KAPPA-B; GLYCATION
   END-PRODUCTS; STELLATE CELLS; INSULIN-RESISTANCE; OXIDATIVE STRESS;
   ADIPOSE-TISSUE; TRANSCRIPTIONAL REGULATION; PROINFLAMMATORY ACTIONS
AB Non-alcoholic fatty liver disease (NAFLD) has become the most common liver disease in Western countries. The more severe form of this condition, non-alcoholic steatohepatitis (NASH), may progress to cirrhosis and its complications. Fibrosis and cirrhosis are the final outcomes of all chronic liver diseases; however, some morphological and biological differences distinguish fibrosis due to NASH from the forms secondary to other causes of liver damage. Fibrosis due to NASH develops primarily in the pericentral areas, surrounding groups of hepatocytes and thickening the space of Disse. This pericellular fibrosis eventually forms septa isolating regenerating nodules. The main cell type responsible for extracellular matrix deposition is represented by hepatic stellate cells that undergo activation in conditions of liver injury enabling them to participate in the liver wound healing process. Although the profibrogenic mechanisms operating in NASH are partly in common with those observed in other chronic liver diseases, the altered pattern of circulating adipokines, oxidative stress generation and the hormonal profile associated with the metabolic syndrome might have a specific role for the induction of fibrogenesis in this condition. In this paper, we review recent developments regarding the basic mechanisms of NASH and the involvement of hepatic stellate cells in this disease. Copyright (C) 2010 S. Karger AG, Basel
C1 [Rombouts, Krista; Marra, Fabio] Univ Firenze, Dipartimento Med Interna, IT-50134 Florence, Italy.
C3 University of Florence
RP Marra, F (corresponding author), Univ Firenze, Dipartimento Med Interna, Viale Morgagni 85, IT-50134 Florence, Italy.
EM f.marra@dmi.unifi.it
RI Rombouts, Krista/ABB-2602-2020; Rombouts, Krista/AAE-8179-2020; Marra,
   Fabio/K-7263-2016
OI Rombouts, Krista/0000-0001-9440-0571; Marra, Fabio/0000-0001-8629-0878
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NR 91
TC 45
Z9 56
U1 0
U2 12
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0257-2753
EI 1421-9875
J9 DIGEST DIS
JI Dig. Dis.
PY 2010
VL 28
IS 1
BP 229
EP 235
DI 10.1159/000282094
PG 7
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Gastroenterology & Hepatology
GA 594YY
UT WOS:000277578800034
PM 20460917
DA 2025-06-11
ER

PT J
AU Veronese, N
   Ragusa, FS
   Dominguez, LJ
   Cusumano, C
   Barbagallo, M
AF Veronese, Nicola
   Ragusa, Francesco Saverio
   Dominguez, Ligia J.
   Cusumano, Claudia
   Barbagallo, Mario
TI Mediterranean diet and osteoarthritis: an update
SO AGING CLINICAL AND EXPERIMENTAL RESEARCH
LA English
DT Review
DE Mediterranean diet; Osteoarthritis; Inflammation; Oxidative stress;
   Pain; Older adults
ID METABOLIC SYNDROME; INFLAMMATORY DISEASE; OBESITY; CONSUMPTION;
   PREVALENCE; INCREASES; BURDEN; HEALTH; ROLES
AB The Mediterranean diet has gained significant attention for its potential health benefits on diverse pathological conditions including osteoarthritis (OA), a prevalent degenerative joint disease characterized by cartilage breakdown and inflammation. Numerous observational studies have suggested that adherence to the Mediterranean diet, may have protective effects against OA. The abundance of antioxidants and anti-inflammatory compounds and omega-3 fatty acids, among the Mediterranean diet components is believed to contribute to its beneficial effects on OA. Research investigating the association between the Mediterranean diet and OA has shown promising results. Several observational studies have reported that adherence to the Mediterranean diet is associated with a reduced risk of developing OA and with lower severity of OA symptoms. Additionally, intervention studies have demonstrated improvements in pain, function, and quality of life among OA patients following a Mediterranean diet intervention. Furthermore, emerging evidence suggests potential mechanisms underlying the protective effects of the Mediterranean diet against OA, including its ability to reduce inflammation, oxidative stress, and cartilage degradation. However, further well-designed randomized controlled trials and mechanistic studies are needed to elucidate the precise mechanisms and establish causality. In conclusion, the Mediterranean diet appears to be a promising dietary approach for the prevention and management of OA. Its rich array of nutrients and bioactive compounds may exert protective effects against OA development and progression, although more research is warranted to confirm these findings and elucidate underlying mechanisms.
C1 [Veronese, Nicola; Ragusa, Francesco Saverio; Cusumano, Claudia; Barbagallo, Mario] Univ Palermo, Dept Hlth Promot Mother & Child Care, Internal Med & Med Specialties, Palermo, Italy.
   [Dominguez, Ligia J.] Kore Univ Enna, Dept Med & Surg, Piazza Univ, I-94100 Enna, Italy.
C3 University of Palermo; Universita Kore di ENNA
RP Veronese, N (corresponding author), Univ Palermo, Dept Hlth Promot Mother & Child Care, Internal Med & Med Specialties, Palermo, Italy.
EM nicola.veronese@unipa.it
RI Veronese, Nicola/K-4343-2018; BARBAGALLO, MARIO/K-4794-2017; Barbara,
   C./AAF-3397-2020
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NR 67
TC 2
Z9 2
U1 2
U2 2
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1594-0667
EI 1720-8319
J9 AGING CLIN EXP RES
JI Aging Clin. Exp. Res.
PD DEC 3
PY 2024
VL 36
IS 1
AR 231
DI 10.1007/s40520-024-02883-8
PG 10
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA O2S2W
UT WOS:001369685100005
PM 39625615
OA hybrid
DA 2025-06-11
ER

PT J
AU McMurray, F
   MacFarlane, M
   Kim, K
   Patten, DA
   Wei-LaPierre, L
   Fullerton, MD
   Harper, ME
AF McMurray, Fiona
   MacFarlane, Megan
   Kim, Kijoo
   Patten, David A.
   Wei-LaPierre, Lan
   Fullerton, Morgan D.
   Harper, Mary-Ellen
TI Maternal diet-induced obesity alters muscle mitochondrial function in
   offspring without changing insulin sensitivity
SO FASEB JOURNAL
LA English
DT Article
DE type 2 diabetes; mitochondria; reactive oxygen species; maternal
   overnutrition; insulin resistance
ID PROTEIN-KINASE-C; SKELETAL-MUSCLE; OXIDATIVE STRESS; SUPEROXIDE FLASHES;
   METABOLIC SYNDROME; ANIMAL-MODELS; BIRTH-WEIGHT; RESISTANCE; PREGNANCY;
   PHOSPHORYLATION
AB In utero overnutrition can predispose offspring to metabolic disease. Although the mechanisms are unclear, increased oxidative stress accelerating cellular aging has been shown to play a role. Mitochondria are the main site of reactive oxygen species (ROS) production in most cell types. Levels of ROS and the risk for oxidative damage are dictated by the balance between ROS production and antioxidant defense mechanisms. Originally considered as toxic species, physiologic levels of ROS are now known to be essential cell signaling molecules. Using a model of maternal over-nutrition in C57BL6N mice, we investigate the mechanisms involved in the development of insulin resistance (IR) in muscle. In red and white gastrocnemius musdes of offspring, we are the first to report characteristics of oxidative phosphorylation, H2O2 production, activity of mitoflashes, and electron transport chain supercomplex formation. Results demonstrate altered mitochondrial function with reduced response to glucose in offspring of mice fed a high-fat and high-sucrose diet, increases in mitochondrial leak respiration, and a reduction in ROS production in red gastrocnemius in response to palmitoyl carnitine. We also demonstrate differences in supercomplex formation between red and white gastrocnemius, which may be integral to fiber-type specialization. We condude that in this model of maternal overnutrition, mitochondrial alterations occur before the development of IR.
C1 [McMurray, Fiona; MacFarlane, Megan; Kim, Kijoo; Patten, David A.; Fullerton, Morgan D.; Harper, Mary-Ellen] Univ Ottawa, Fac Med, Dept Biochem Microbiol & Immunol, 451 Smyth Rd, Ottawa, ON K1H 8M5, Canada.
   [McMurray, Fiona; Patten, David A.; Harper, Mary-Ellen] Ottawa Inst Syst Biol, Ottawa, ON, Canada.
   [Wei-LaPierre, Lan] Univ Rochester, Sch Med & Dent, Dept Physiol & Pharmacol, Rochester, NY USA.
C3 University of Ottawa; University of Ottawa; University of Rochester
RP Harper, ME (corresponding author), Univ Ottawa, Fac Med, Dept Biochem Microbiol & Immunol, 451 Smyth Rd, Ottawa, ON K1H 8M5, Canada.
EM mharper@uottawa.ca
RI Wei-LaPierre, Lan/HMV-8333-2023; Harper, Mary-Ellen/C-3103-2009
FU Canadian Institutes of Health Research (CIHR) [FDN143278, PJT148634];
   CIHR New Investigator Award
FX The authors thank Jian Xuan and the animal care staff at the University
   of Ottawa for dedicated assistance during this study. The authors thank
   Chantal Pileggi and Gaganvir Parmar (University of Ottawa) for technical
   assistance addressing the reviewer comments. The authors also thank
   Prof. Robert Dirksen (University of Rochester) for providing us with the
   mitochondrially targeted circularly permuted yellow fluorescent protein
   (mt-cpYFP) mice. This work was also supported by Canadian Institutes of
   Health Research (CIHR) funding to M.E.H. (FDN143278) and to M.D.F.
   (PJT148634). M.D.F. is supported by a CIHR New Investigator Award. The
   authors declare no conflicts of interest.
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NR 68
TC 14
Z9 16
U1 0
U2 9
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0892-6638
EI 1530-6860
J9 FASEB J
JI Faseb J.
PD DEC
PY 2019
VL 33
IS 12
BP 13515
EP 13526
DI 10.1096/fj.201901150R
PG 12
WC Biochemistry & Molecular Biology; Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA KC9BO
UT WOS:000507466100038
PM 31581846
OA Bronze
DA 2025-06-11
ER

PT J
AU Morsi, M
   Maher, A
   Aboelmagd, O
   Johar, D
   Bernstein, L
AF Morsi, Mahmoud
   Maher, Ahmed
   Aboelmagd, Omnia
   Johar, Dina
   Bernstein, Larry
TI A shared comparison of diabetes mellitus and neurodegenerative disorders
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Article
DE Diabetes mellitus; endoplasmic reticulum; mitochondria;
   neurodegeneration; stress
ID ALZHEIMERS-DISEASE; PARKINSONS-DISEASE; AUTOPHAGY; STRESS
AB Diabetes mellitus (DM) is one of the most common diseases in the world population, associated with obesity, pancreatic endocrine changes, cardiovascular disease, renal glomerular disease, cerebrovascular disease, peripheral neuropathy, neurodegenerative disease, retinal disease, sleep apnea, some of which are bundled into the metabolic syndrome. The main characteristic of this disease is hyperglycemia, and often with albuminuria. Nevertheless, the classic features, with ketoacidosis in the extreme, are only a first layer of description of this condition. The description of the islet cells of the endocrine pancreas was first described by Opie, and the discovery of insulin by tying off the exocrine pancreatic ducts followed. We later find that the -cells secrete insulin and glucagon, which synchronously stimulate or suppress glycogenolysis, and that insulin is essential for glucose intake into the cell. There are yet two other layers for our understanding of diabetes and the effects of its dysfunction, which is the basis for understanding the system-wide expression of the disease. We describe the molecular basis for the central nervous system neuropathic diseases that are associated with both Type 1 DM (T1DM) and Type 2 DM (T2DM), but more so with T2DM. T2DM is an autoimmune disease that destroys the insulin secreting islet cells. T2DM is the diabetes that is associated with an imbalance in the glucagon/insulin homeostasis that leads to the formation of amyloid deposits in the brain, pancreatic islet cells, and possibly the kidney glomerulus.
C1 [Morsi, Mahmoud] Menoufia Univ, Fac Med, Menoufia, Egypt.
   [Maher, Ahmed] Natl Res Ctr, Zoonot Dis Dept, Giza, Egypt.
   [Aboelmagd, Omnia] Cairo Univ, Fac Med, Cairo, Egypt.
   [Johar, Dina] Ain Shams Univ, Fac Women Arts Sci & Educ, Dept Biochem & Nutr, Cairo, Egypt.
   [Johar, Dina] Univ Manitoba, Max Rady Fac Hlth Sci, Rady Coll Med, Dept Physiol & Pathophysiol, Winnipeg, MB, Canada.
   [Bernstein, Larry] Triplex Consulting, Northampton, MA USA.
C3 Egyptian Knowledge Bank (EKB); Menofia University; Egyptian Knowledge
   Bank (EKB); National Research Centre (NRC); Egyptian Knowledge Bank
   (EKB); Cairo University; Egyptian Knowledge Bank (EKB); Ain Shams
   University; University of Manitoba
RP Johar, D (corresponding author), Univ Manitoba, Max Rady Fac Hlth Sci, Rady Coll Med, Physiol & Pathophysiol, Winnipeg, MB R3E 1Y7, Canada.
EM dinajohar@gmail.com
RI morsi, mahmoud/Y-8086-2019; AboElmagd, Ahmed/KGL-5479-2024; Johar,
   Dina/JTV-7123-2023
OI Maher, Ahmed/0000-0002-7572-9053; morsi, mahmoud/0000-0001-6825-7361;
   JOHAR, DINA/0000-0003-0866-9959; Morsi, Mahmoud/0000-0002-6621-0751
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NR 24
TC 29
Z9 30
U1 1
U2 14
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0730-2312
EI 1097-4644
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PD FEB
PY 2018
VL 119
IS 2
BP 1249
EP 1256
DI 10.1002/jcb.26261
PG 8
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA FQ9UX
UT WOS:000418708300001
PM 28681964
DA 2025-06-11
ER

PT J
AU Bonnefont-Rousselot, D
AF Bonnefont-Rousselot, Dominique
TI Resveratrol and Cardiovascular Diseases
SO NUTRIENTS
LA English
DT Review
DE antioxidant; atherosclerosis; clinical; heart failure; hypertension;
   inflammation; myocardial infarction; preclinical; resveratrol
ID IMPROVES CARDIAC-FUNCTION; BLOOD MONONUCLEAR-CELLS;
   LOW-DENSITY-LIPOPROTEIN; SMOOTH-MUSCLE-CELLS; OXIDATIVE STRESS;
   NITRIC-OXIDE; METABOLIC SYNDROME; ENDOTHELIAL FUNCTION;
   MYOCARDIAL-ISCHEMIA; PRIMARY PREVENTION
AB The increased incidence of cardiovascular diseases (CVDs) has stimulated research for substances that could improve cardiovascular health. Among them, resveratrol (RES), a polyphenolic compound notably present in grapes and red wine, has been involved in the "French paradox". RES is known for its antioxidant and anti-inflammatory properties and for its ability to upregulate endothelial NO synthase (eNOS). RES was able to scavenge (OH)-O-center dot/O-2(center dot-) and peroxyl radicals, which can limit the lipid peroxidation processes. Moreover, in bovine aortic endothelial cells (BAEC) under glucose-induced oxidative stress, RES restored the activity of dimethylargininedimethylaminohydrolase (DDAH), an enzyme that degrades an endogenous inhibitor of eNOS named asymmetric dimethylarginine (ADMA). Thus, RES could improve (NO)-N-center dot availability and decrease the endothelial dysfunction observed in diabetes. Preclinical studies have made it possible to identify molecular targets (SIRT-1, AMPK, Nrf2, NF kappa B ...); however, there are limited human clinical trials, and difficulties in the interpretation of results arise from the use of high-dose RES supplements in research studies, whereas low RES concentrations are present in red wine. The discussions on potential beneficial effects of RES in CVDs (atherosclerosis, hypertension, stroke, myocardial infarction, heart failure) should compare the results of preclinical studies with those of clinical trials.
C1 [Bonnefont-Rousselot, Dominique] Paris Descartes Univ, Fac Pharm, Dept Biochem, Sorbonne Paris Cite, F-75006 Paris, France.
   [Bonnefont-Rousselot, Dominique] Pitie Salpetriere Charles Foix Hosp, AP HP, Dept Metab Biochem, F-75013 Paris, France.
   [Bonnefont-Rousselot, Dominique] UPMC, La Pitie Hosp, INSERM, UMR S 1166,ICAN, F-75013 Paris, France.
C3 Universite Paris Cite; Assistance Publique Hopitaux Paris (APHP);
   Hopital Universitaire Pitie-Salpetriere - APHP; Sorbonne Universite;
   Hopital Universitaire Charles-Foix - APHP; Institut National de la Sante
   et de la Recherche Medicale (Inserm); Assistance Publique Hopitaux Paris
   (APHP); Hopital Universitaire Pitie-Salpetriere - APHP; Sorbonne
   Universite
RP Bonnefont-Rousselot, D (corresponding author), Paris Descartes Univ, Fac Pharm, Dept Biochem, Sorbonne Paris Cite, F-75006 Paris, France.; Bonnefont-Rousselot, D (corresponding author), Pitie Salpetriere Charles Foix Hosp, AP HP, Dept Metab Biochem, F-75013 Paris, France.; Bonnefont-Rousselot, D (corresponding author), UPMC, La Pitie Hosp, INSERM, UMR S 1166,ICAN, F-75013 Paris, France.
EM dominique.rousselot@aphp.fr
RI Rousselot, Bonnefont/U-7434-2019
OI Bonnefont-Rousselot, Dominique/0000-0003-4689-9202
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NR 161
TC 318
Z9 345
U1 3
U2 129
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD MAY
PY 2016
VL 8
IS 5
AR 250
DI 10.3390/nu8050250
PG 24
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA DP8XI
UT WOS:000378780900011
PM 27144581
OA Green Published, Green Submitted, gold
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Manti, S
   Romano, C
   Chirico, V
   Filippelli, M
   Cuppari, C
   Loddo, I
   Salpietro, C
   Arrigo, T
AF Manti, Sara
   Romano, Claudio
   Chirico, Valeria
   Filippelli, Martina
   Cuppari, Caterina
   Loddo, Italia
   Salpietro, Carmelo
   Arrigo, Teresa
TI Nonalcoholic Fatty Liver Disease/Non-Alcoholic Steatohepatitis in
   Childhood: Endocrine-Metabolic "Mal-Programming"
SO HEPATITIS MONTHLY
LA English
DT Review
DE Non-Alcoholic Fatty Liver Disease; Mallory Bodies; Oxidative Stress
ID NECROSIS-FACTOR-ALPHA; INSULIN-RESISTANCE; OBESE CHILDREN; ASSOCIATION;
   PROTEIN; GENE; POLYMORPHISMS; GENOTYPE; GLUCOKINASE; ACTIVATION
AB Context: Nonalcoholic Fatty Liver Disease (NAFLD) is the major chronic liver disease in the pediatric population. NAFLD includes a broad spectrum of abnormalities (inflammation, fibrosis and cirrhosis), ranging from accumulation of fat (also known as steatosis) towards non-alcoholic steatohepatitis (NASH). The development of NAFLD in children is significantly increased.
   Evidence Acquisition: A literature search of electronic databases was undertaken for the major studies published from 1998 to today. The databases searched were: PubMed, EMBASE, Orphanet, Midline and Cochrane Library. We used the key words: "non-alcoholic fatty liver disease, children, non-alcoholic steatohepatitis and fatty liver".
   Results: NAFLD/NASH is probably promoted by "multiple parallel hits": environmental and genetic factors, systemic immunological disorders (oxidative stress, persistent-low grade of inflammation) as well as obesity and metabolic alterations (insulin resistance and metabolic syndrome). However its exact cause still underdiagnosed and unknown.
   Conclusions: Pediatric NAFLD/NASH is emerging problem. Longitudinal follow-up studies, unfortunately still insufficient, are needed to better understand the natural history and outcome of NAFLD in children. This review focuses on the current knowledge regarding the epidemiology, pathogenesis, environmental, genetic and metabolic factors of disease. The review also highlights the importance of studying the underlying mechanisms of pediatric NAFLD and the need for complete and personalized approach in the management of NAFLD/NASH.
C1 [Manti, Sara; Romano, Claudio; Chirico, Valeria; Filippelli, Martina; Cuppari, Caterina; Loddo, Italia; Salpietro, Carmelo; Arrigo, Teresa] Univ Messina, Dept Pediat Sci, Genet & Pediat Immunol Unit, Messina, Italy.
C3 University of Messina
RP Arrigo, T (corresponding author), Univ Messina, Dept Pediat Sci, Genet & Pediat Immunol Unit, Messina, Italy.
EM tarrigo@unime.it
RI Damiano, Carmelo/AAL-2945-2020; Romano, Claudio/L-1950-2016
OI Loddo, Italia/0000-0002-4400-1596; Romano, Claudio/0000-0001-8827-2091
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NR 74
TC 17
Z9 17
U1 0
U2 3
PU KOWSAR PUBL
PI HOENSBROEK
PA PATERSWEG 22,, HOENSBROEK, LIMBURG 6431 GC, NETHERLANDS
SN 1735-143X
EI 1735-3408
J9 HEPAT MON
JI Hepat. Mon.
PD MAY
PY 2014
VL 14
IS 5
AR e17641
DI 10.5812/hepatmon.17641
PG 9
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA AT0PI
UT WOS:000344637300010
PM 24829591
OA Green Published, hybrid, Green Submitted
DA 2025-06-11
ER

PT J
AU Marçal, AC
   Leonelli, M
   Fiamoncini, J
   Deschamps, FC
   Rodrigues, MAM
   Curi, R
   Carpinelli, AR
   Britto, LRG
   Carvalho, CRO
AF Marcal, Anderson C.
   Leonelli, Mauro
   Fiamoncini, Jarlei
   Deschamps, Francisco C.
   Rodrigues, Maria A. M.
   Curi, Rui
   Carpinelli, Angelo R.
   Britto, Luiz R. G.
   Carvalho, Carla R. O.
TI Diet-induced obesity impairs AKT signalling in the retina and causes
   retinal degeneration
SO CELL BIOCHEMISTRY AND FUNCTION
LA English
DT Article
DE retina; insulin resistance; obesity; high-fat diet; NOS isoforms; AKT;
   cell death; lipid peroxidation
ID NITRIC-OXIDE SYNTHASE; INDUCED INSULIN-RESISTANCE; DIABETIC-RETINOPATHY;
   OXIDATIVE STRESS; MITOCHONDRIAL SUPEROXIDE; OXYGENATION RESPONSE;
   NITRATIVE STRESS; NAD(P)H OXIDASE; RAT RETINA; EXPRESSION
AB Retinopathy, a common complication of diabetes, is characterized by an unbalanced production of nitric oxide (NO), a process regulated by nitric oxide synthase (NOS). We hypothesized that retinopathy might stem from changes in the insulin receptor substrate (IRS)/PI3K/AKT pathway and/or expression of NOS isoforms. Thus, we analysed the morphology and apoptosis index in retinas of obese rats in whom insulin resistance had been induced by a high-fat diet (HFD). Immunoblotting analysis revealed that the retinal tissue of HFD rats had lower levels of AKT1, eNOS and nNOS protein than those of samples taken from control animals. Furthermore, immunohistochemical analyses indicated higher levels of iNOS and 4-hydroxynonenal and a larger number of apoptotic nuclei in HFD rats. Finally, both the inner and outer retinal layers of HFD rats were thinner than those in their control counterparts. When considered alongside previous results, these patterns suggest two major ways in which HFD might impact animals: direct activity of ingested fatty acids and/or via insulin-resistance-induced changes in intracellular pathways. We discuss these possibilities in further detail and advocate the use of this animal model for further understanding relationships between retinopathy, metabolic syndrome and type 2 diabetes. Copyright (c) 2012 John Wiley & Sons, Ltd.
C1 [Marcal, Anderson C.; Leonelli, Mauro; Fiamoncini, Jarlei; Curi, Rui; Carpinelli, Angelo R.; Britto, Luiz R. G.; Carvalho, Carla R. O.] Univ Sao Paulo, Dept Fisiol & Biofis, Inst Ciencias Biomed, BR-05508 Sao Paulo, Brazil.
   [Deschamps, Francisco C.] Empresa Pesquisa Agr & Extensao Rural Santa Catar, Itajai, SC, Brazil.
   [Rodrigues, Maria A. M.] Univ Estadual Paulista, UNESP, Fac Med Botucatu, Dept Patol, Sao Paulo, SP, Brazil.
C3 Universidade de Sao Paulo; Universidade Estadual Paulista
RP Carvalho, CRO (corresponding author), Av Prof Lineu Prestes 1524,ICB I Sala 121,Cidade, BR-05389970 Sao Paulo, Brazil.
EM acmarcal@yahoo.com.br; croc@icb.usp.br
RI Carpinelli, Angelo/G-8566-2011; rodrigues, maria/J-3073-2013; Curi,
   Rui/C-9351-2012; Carvalho, Carla/H-6476-2018; Leonelli,
   Mauro/J-5718-2015; Fiamoncini, Jarlei/L-5497-2017
OI Carpinelli, Angelo Rafael/0000-0002-0781-4934; Carvalho,
   Carla/0000-0001-5824-8656; Leonelli, Mauro/0000-0001-9073-2405;
   Marchesan Rodrigues, maria/0000-0002-8355-1929; Fiamoncini,
   Jarlei/0000-0002-8456-983X
FU Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP); Conselho
   Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
FX This work was supported by grants from Fundacao de Amparo a Pesquisa do
   Estado de Sao Paulo (FAPESP) and Conselho Nacional de Desenvolvimento
   Cientifico e Tecnologico (CNPq). We also gratefully acknowledge Mrs
   Luciene M Ribeiro and to Mr Adilson da S. Alves for technical assistance
   and Editage for providing editorial assistance.
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NR 68
TC 24
Z9 30
U1 1
U2 13
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0263-6484
J9 CELL BIOCHEM FUNCT
JI Cell Biochem. Funct.
PD JAN
PY 2013
VL 31
IS 1
BP 65
EP 74
DI 10.1002/cbf.2861
PG 10
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA 070YD
UT WOS:000313549300010
PM 22915345
DA 2025-06-11
ER

PT J
AU Pang, J
   Chan, DC
   Barrett, PHR
   Watts, GF
AF Pang, Jing
   Chan, Dick C.
   Barrett, P. Hugh R.
   Watts, Gerald F.
TI Postprandial dyslipidaemia and diabetes: mechanistic and therapeutic
   aspects
SO CURRENT OPINION IN LIPIDOLOGY
LA English
DT Review
DE diabetes; mechanisms; postprandial dyslipidaemia; therapy
ID TRIGLYCERIDE-RICH LIPOPROTEINS; IMPAIRED GLUCOSE-TOLERANCE;
   APOLIPOPROTEIN B-100 KINETICS; CORONARY-ARTERY-DISEASE; INTIMA-MEDIA
   THICKNESS; FREE FATTY-ACIDS; CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME;
   ENDOTHELIAL DYSFUNCTION; OXIDATIVE STRESS
AB Purpose of review
   There has been a resurgence of interest in the role of triglyceride-rich lipoproteins in the development of atherosclerosis and cardiovascular disease, and this is particularly relevant to diabetes mellitus and the postprandial state.
   Recent findings
   Recent evidence suggests that insulin resistance in diabetes induces postprandial dyslipidemia by increasing the enterocytic production of chylomicrons and their remnant particles, but an impaired clearance capacity is also involved. Postprandial dyslipidaemia in diabetes induces oxidative stress, inflammation and endothelial dysfunction and this may be compounded by dysglycaemia. New guidelines for managing hypertriglyceridaemia in diabetes have been published, first-line therapies being improved glycaemic control, treatment of other secondary causes of dyslipidaemia and statin therapy, followed by judicious use of fibrates, n-3 fatty acids or niacin. A new role for incretin-based therapies in regulating dyslipidaemia has been identified.
   Summary
   Postprandial dyslipidaemia is a pivotal mechanism whereby diabetes can induce and accelerate atherosclerosis. Regulating the plasma concentrations of triglyceride-rich lipoproteins may decrease the cardiovascular complications of diabetes. The mechanisms of action of incretin-based treatments on dyslipidaemia and endothelial dysfunction need further investigation. The efficacy of new therapies targeted at postprandial dysmetabolism in diabetes need to be confirmed, against best current levels of care, in clinical endpoint trials.
C1 [Watts, Gerald F.] Royal Perth Hosp, Lipid Disorders Clin, Perth, WA 6847, Australia.
   [Pang, Jing; Chan, Dick C.; Barrett, P. Hugh R.; Watts, Gerald F.] Univ Western Australia, Sch Med & Pharmacol, Metabol Res Ctr, Perth, WA 6009, Australia.
C3 East Metropolitan Health Service; Royal Perth Hospital; University of
   Western Australia; University of Western Australia
RP Watts, GF (corresponding author), Royal Perth Hosp, Lipid Disorders Clin, GPO Box X2213, Perth, WA 6847, Australia.
EM gerald.watts@uwa.edu.au
RI Pang, Jing/T-6397-2019; Watts, Gerald/HII-8530-2022; Barrett,
   Hugh/B-2745-2011
OI Barrett, Peter Hugh/0000-0003-3223-6125; Watts,
   Gerald/0000-0003-2276-1524; Pang, Jing/0000-0002-9700-6948
FU Pfizer; Astra Zeneca; MSD; Abbott; Boehringer-Ingelheim; Sanofi;
   Glaxo-Wellcome; Roche; Genfit Genzyme; Amgen; Novartis
FX G.F.W. has received honoraria for advisory boards and lectures or
   research support from from: Pfizer, Astra Zeneca, MSD, Abbott,
   Boehringer-Ingelheim, Sanofi, Novartis, Glaxo-Wellcome, Roche, Genfit
   Genzyme, Amgen.
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NR 94
TC 21
Z9 22
U1 0
U2 7
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0957-9672
EI 1473-6535
J9 CURR OPIN LIPIDOL
JI Curr. Opin. Lipidology
PD AUG
PY 2012
VL 23
IS 4
BP 303
EP 309
DI 10.1097/MOL.0b013e328354c790
PG 7
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism; Peripheral
   Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism;
   Cardiovascular System & Cardiology
GA 975PH
UT WOS:000306522800005
PM 22595742
DA 2025-06-11
ER

PT J
AU do Prado, FG
   Pagnoncelli, MGB
   Pereira, GVD
   Karp, SG
   Soccol, CR
AF do Prado, Fernanda Guilherme
   Binder Pagnoncelli, Maria Giovana
   de Melo Pereira, Gilberto Vinicius
   Karp, Susan Grace
   Soccol, Carlos Ricardo
TI Fermented Soy Products and Their Potential Health Benefits: A Review
SO MICROORGANISMS
LA English
DT Review
DE oxidative stress; fermented soybean foods; bioactive compounds;
   genistein; daidzein
ID ENZYME INHIBITORY PEPTIDES; INDUCED INSULIN-RESISTANCE; OXIDATIVE
   STRESS; ANTIOXIDANT ACTIVITIES; INFLAMMATORY MARKERS; MICROBIAL
   COMMUNITY; BIOACTIVE COMPOUNDS; METABOLIC SYNDROME; COVID-19 PATIENTS;
   STARTER CULTURE
AB In the growing search for therapeutic strategies, there is an interest in foods containing natural antioxidants and other bioactive compounds capable of preventing or reversing pathogenic processes associated with metabolic disease. Fermentation has been used as a potent way of improving the properties of soybean and their components. Microbial metabolism is responsible for producing the beta-glucosidase enzyme that converts glycosidic isoflavones into aglycones with higher biological activity in fermented soy products, in addition to several end-metabolites associated with human health development, including peptides, phenolic acids, fatty acids, vitamins, flavonoids, minerals, and organic acids. Thus, several products have emerged from soybean fermentation by fungi, bacteria, or a combination of both. This review covers the key biological characteristics of soy and fermented soy products, including natto, miso, tofu, douchi, sufu, cheonggukjang, doenjang, kanjang, meju, tempeh, thua-nao, kinema, hawaijar, and tungrymbai. The inclusion of these foods in the diet has been associated with the reduction of chronic diseases, with potential anticancer, anti-obesity, antidiabetic, anticholesterol, anti-inflammatory, and neuroprotective effects. These biological activities and the recently studied potential of fermented soybean molecules against SARS-CoV-2 are discussed. Finally, a patent landscape is presented to provide the state-of-the-art of the transfer of knowledge from the scientific sphere to the industrial application.
C1 [do Prado, Fernanda Guilherme; de Melo Pereira, Gilberto Vinicius; Karp, Susan Grace; Soccol, Carlos Ricardo] Fed Univ Parana UFPR, Dept Bioproc Engn & Biotechnol, BR-81530900 Curitiba, Parana, Brazil.
   [Binder Pagnoncelli, Maria Giovana] Fed Univ Technol Parana UTFPR, Bioproc Engn & Biotechnol Dept, BR-80230900 Curitiba, Parana, Brazil.
C3 Universidade Federal do Parana; Universidade Tecnologica Federal do
   Parana
RP Pereira, GVD; Soccol, CR (corresponding author), Fed Univ Parana UFPR, Dept Bioproc Engn & Biotechnol, BR-81530900 Curitiba, Parana, Brazil.
EM gilbertovinicius@ufpr.br; soccol@ufpr.br
RI de Melo Pereira, Gilberto/F-4867-2013; Soccol, Carlos/S-6112-2019; Karp,
   Susan/C-5728-2016; Pagnoncelli, Maria/N-7255-2017; Do Prado,
   Fernanda/J-6231-2015
OI Do Prado, Fernanda/0000-0001-8466-3749; Soccol, Carlos
   Ricardo/0000-0001-7630-6864
FU Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES);
   Conselho Nacional de Desenvolvimento Cientifico e Tecnologico do Brasil
   (CNPq)
FX This work was funded by Coordenacao de Aperfeicoamento de Pessoal de
   Nivel Superior (CAPES) and Conselho Nacional de Desenvolvimento
   Cientifico e Tecnologico do Brasil (CNPq).
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NR 198
TC 61
Z9 62
U1 7
U2 104
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-2607
J9 MICROORGANISMS
JI Microorganisms
PD AUG
PY 2022
VL 10
IS 8
AR 1606
DI 10.3390/microorganisms10081606
PG 24
WC Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Microbiology
GA 4C6SH
UT WOS:000846580000001
PM 36014024
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Zhao, Y
   Wang, QY
   Zeng, LT
   Wang, JJ
   Liu, Z
   Fan, GQ
   Li, J
   Cai, JP
AF Zhao, Yue
   Wang, Qing-Yu
   Zeng, Lv-Tao
   Wang, Jing-Jing
   Liu, Zhen
   Fan, Guo-Qing
   Li, Jin
   Cai, Jian-Ping
TI Long-Term High-Fat High-Fructose Diet Induces Type 2 Diabetes in Rats
   through Oxidative Stress
SO NUTRIENTS
LA English
DT Article
DE Western dietary pattern; metabolic disorders; pancreas; islets;
   single-cell RNA sequencing analysis
ID INDUCED INSULIN-RESISTANCE; NUCLEIC-ACID OXIDATION; METABOLIC SYNDROME;
   URINARY MARKERS; BETA-CELLS; PATTERNS; RISK; CONSUMPTION; OBESITY;
   INFLAMMATION
AB Long-term consumption of a Western diet is a major cause of type 2 diabetes mellitus (T2DM). However, the effects of diet on pancreatic structure and function remain unclear. Rats fed a high-fat, high-fructose (HFHF) diet were compared with rats fed a normal diet for 3 and 18 months. Plasma biochemical parameters and inflammatory factors were used to reflect metabolic profile and inflammatory status. The rats developed metabolic disorders, and the size of the islets in the pancreas increased after 3 months of HFHF treatment but decreased and became irregular after 18 months. Fasting insulin, C-peptide, proinsulin, and intact proinsulin levels were significantly higher in the HFHF group than those in the age-matched controls. Plasmatic oxidative parameters and nucleic acid oxidation markers (8-oxo-Gsn and 8-oxo-dGsn) became elevated before inflammatory factors, suggesting that the HFHF diet increased the degree of oxidative stress before affecting inflammation. Single-cell RNA sequencing also verified that the transcriptional level of oxidoreductase changed differently in islet subpopulations with aging and long-term HFHF diet. We demonstrated that long-term HFHF diet and aging-associated structural and transcriptomic changes that underlie pancreatic islet functional decay is a possible underlying mechanism of T2DM, and our study could provide new insights to prevent the development of diet-induced T2DM.
C1 [Zhao, Yue; Wang, Qing-Yu; Liu, Zhen; Fan, Guo-Qing; Li, Jin; Cai, Jian-Ping] Chinese Acad Med Sci, Natl Ctr Gerontol, Beijing Inst Geriatr, Inst Geriatr Med,Key Lab Geriatr,Beijing Hosp,Nat, Beijing 100730, Peoples R China.
   [Zhao, Yue; Liu, Zhen; Fan, Guo-Qing; Cai, Jian-Ping] Peking Union Med Coll, Grad Sch, Beijing 100730, Peoples R China.
   [Zeng, Lv-Tao] Peking Univ, Natl Ctr Gerontol, Beijing Hosp, Sch Clin Med 5,Natl Hlth Commiss, Beijing 100730, Peoples R China.
   [Wang, Jing-Jing] Zhengzhou Univ, Henan Prov Peoples Hosp, Dept Clin Lab, Peoples Hosp, Zhengzhou 450066, Peoples R China.
C3 Chinese Academy of Medical Sciences - Peking Union Medical College;
   Beijing Hospital; Chinese Academy of Medical Sciences - Peking Union
   Medical College; Peking Union Medical College; Beijing Hospital; Peking
   University; Zhengzhou University
RP Cai, JP (corresponding author), Chinese Acad Med Sci, Natl Ctr Gerontol, Beijing Inst Geriatr, Inst Geriatr Med,Key Lab Geriatr,Beijing Hosp,Nat, Beijing 100730, Peoples R China.; Cai, JP (corresponding author), Peking Union Med Coll, Grad Sch, Beijing 100730, Peoples R China.
EM vita1023@163.com; daisyqingyu@outlook.com; zengtiancai@sina.com;
   15133919987@163.com; jane_computer@sina.com; missyueying@163.com;
   niyani88@126.com; caijianping3200@bjhmoh.cn
OI Wang, Qingyu/0000-0002-9352-0923
FU Ministry of Science and Technology (the National Key R&D Programof
   China) [2018YFC2000300]; CAMS Innovation Fund for Medical Sciences
   [2021-1-I2M-050]; National Natural Science Foundation of China
   [82170856]
FX This research was supported by theMinistry of Science and Technology
   (the National Key R&D Programof China 2018YFC2000300), CAMS Innovation
   Fund forMedical Sciences (No. 2021-1-I2M-050) and the National Natural
   Science Foundation of China (No. 82170856).
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NR 73
TC 22
Z9 22
U1 5
U2 18
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JUN
PY 2022
VL 14
IS 11
AR 2181
DI 10.3390/nu14112181
PG 21
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 2A4GJ
UT WOS:000809462300001
PM 35683981
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Song, YP
   Lv, JW
   Zhao, Y
   Chen, X
   Zhang, ZC
   Fan, YJ
   Zhang, C
   Gao, L
   Huang, YC
   Wang, H
   Xu, DX
AF Ya-Ping Song
   Jin-Wei Lv
   Zhao, Ying
   Chen, Xu
   Zhi-Cheng Zhang
   Yi-Jun Fan
   Zhang, Cheng
   Gao, Lan
   Huang, Yichao
   Wang, Hua
   De-Xiang Xu
TI DNA hydroxymethylation reprogramming of β-oxidation genes mediates
   early-life arsenic-evoked hepatic lipid accumulation in adult mice
SO JOURNAL OF HAZARDOUS MATERIALS
LA English
DT Article
DE Environmental stressor; Arsenic; Hepatic lipid accumulation; DNA
   hydroxymethylation; DNA methylation
ID FATTY LIVER-DISEASE; METABOLIC SYNDROME; EXPOSURE; METHYLTRANSFERASE;
   DEMETHYLATION; MECHANISM; OBESITY; HEALTH; BPA
AB The metabolic disorders are becoming an epidemic disease endangering public health in countries. Environmental factors are mainly reason for the growth of metabolic disorders. Previous research suggests that DNA methylation is a potential mechanism. Recently, it has been reported that DNA hydroxymethylation is also a stable marker of epigenetic reprogramming. Hence, the study aims to investigate whether DNA hydroxymehylation mediates early-life environmental stress-evoked metabolic disorder in adulthood. Mice were orally administered with arsenic (As), an environmental stressor, throughout pregnancy. We show that early-life As exposure induces glucose intolerance and hepatic lipid accumulation in adulthood. Early-life As exposure alters epigenetic reprogramming and expression of lipid metabolism-related genes including beta-oxidation-specific genes in adulthood. Of interest, early-life As exposure alters epigenetic reprogramming of hepatic lipid metabolism partially through reducing DNA hydroxymethylation modification of beta-oxidation-related genes in developing liver. Mechanistically, early-life As exposure suppresses ten-eleven translocation (TET) activity through down-regulating isocitrate dehydrogenases (Idh) and reducing alpha-ketoglutarate (alpha-KG) content in the developing liver. In addition, early-life As exposure inhibits TET1 binding to CpG-rich fragments of beta-oxidation-related genes in developing liver. This study provide novel evidence that early-life environmental stress leads to later life metabolic disorders by altering hepatic DNA hydroxymethylation reprogramming.
C1 [Ya-Ping Song; Jin-Wei Lv; Zhao, Ying; Chen, Xu; Zhi-Cheng Zhang; Yi-Jun Fan; Zhang, Cheng; Gao, Lan; Huang, Yichao; Wang, Hua; De-Xiang Xu] Anhui Med Univ, Dept Toxicol, Hefei 230032, Peoples R China.
C3 Anhui Medical University
RP Xu, DX (corresponding author), Anhui Med Univ, Dept Toxicol, Hefei 230032, Peoples R China.
EM xudex@126.com
RI Fu, Lin/HTM-6145-2023; Song, yaping/GRS-8912-2022; lv,
   jinwei/LEM-6617-2024
OI Huang, Yichao/0000-0003-1186-1300
FU National Natural Science Foundation of China [81930093, 82173565]
FX This work was supported by National Natural Science Foundation of China
   (81930093, 82173565).
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NR 64
TC 16
Z9 17
U1 1
U2 41
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0304-3894
EI 1873-3336
J9 J HAZARD MATER
JI J. Hazard. Mater.
PD MAY 15
PY 2022
VL 430
AR 128511
DI 10.1016/j.jhazmat.2022.128511
EA FEB 2022
PG 13
WC Engineering, Environmental; Environmental Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering; Environmental Sciences & Ecology
GA ZJ9DW
UT WOS:000762601000005
PM 35739688
DA 2025-06-11
ER

PT J
AU Baldini, F
   Portincasa, P
   Grasselli, E
   Damonte, G
   Salis, A
   Bonomo, M
   Florio, M
   Serale, N
   Voci, A
   Gena, P
   Vergani, L
   Calamita, G
AF Baldini, Francesca
   Portincasa, Piero
   Grasselli, Elena
   Damonte, Gianluca
   Salis, Annalisa
   Bonomo, Michela
   Florio, Marilina
   Serale, Nadia
   Voci, Adriana
   Gena, Patrizia
   Vergani, Laura
   Calamita, Giuseppe
TI Aquaporin-9 is involved in the lipid-lowering activity of the
   nutraceutical silybin on hepatocytes through modulation of autophagy and
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SO BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
LA English
DT Article
DE Steatosis; Steatohepatitis; Silybin; Aquaglyceroporins; Hepatic
   glycerol; Mono-unsaturated and saturated fatty acids; Autophagy
ID FATTY LIVER-DISEASE; GLYCEROL PERMEABILITY; PCSK9; EXPRESSION;
   APOPTOSIS; MODEL; ACID; IDENTIFICATION; MICRORNA-122; METABOLISM
AB Hepatic steatosis is the hallmark of non-alcoholic fatty liver disease (NAFLD), the hepatic manifestation of the metabolic syndrome and insulin resistance with potential evolution towards non-alcoholic steatohepatitis (NASH), cirrhosis and hepatocellular carcinoma. Key roles of autophagy and oxidative stress in hepatic lipid accumulation and NAFLD progression are recognized. Here, we employed a rat hepatoma cell model of NAFLD progression made of FaO cells exposed to oleate/palmitate followed or not by TNF alpha treatment to investigate the molecular mechanisms through which silybin, a lipid-lowering nutraceutical, may improve hepatic lipid dyshomeostasis. The beneficial effect of silybin was found to involve amelioration of the fatty acids profile of lipid droplets, stimulation of the mitochondrial oxidation and upregulation of a microRNA of pivotal relevance in hepatic fat metabolism, miR-122. Silybin was also found to restore the levels of Aquaporin-9 (AQP9) and glycerol permeability while reducing the activation of the oxidative stress-dependent transcription factor NF-kappa B, and autophagy turnover. In conclusion, silybin was shown to have molecular effects on signaling pathways that were previously unknown and potentially protect the hepatocyte. These actions intersect TG metabolism, fat-induced autophagy and AQP9-mediated glycerol transport in hepatocytes.
C1 [Baldini, Francesca; Grasselli, Elena; Salis, Annalisa; Serale, Nadia; Voci, Adriana; Vergani, Laura] DISTAV, Dept Earth Environm & Life Sci, Genoa, Italy.
   [Portincasa, Piero] Univ Bari Aldo Moro, Med Sch, Dept Biomed Sci & Human Oncol, Clin Med A Murri, Bari, Italy.
   [Damonte, Gianluca] Univ Genoa, Dept Expt Med, Genoa, Italy.
   [Bonomo, Michela; Florio, Marilina; Gena, Patrizia; Calamita, Giuseppe] Univ Bari Aldo Moro, Dept Biosci Biotechnol & Biopharmaceut, Bari, Italy.
C3 Universita degli Studi di Bari Aldo Moro; University of Genoa;
   Universita degli Studi di Bari Aldo Moro
RP Vergani, L (corresponding author), DISTAV, Dept Earth Environm & Life Sci, Genoa, Italy.; Calamita, G (corresponding author), Univ Bari Aldo Moro, Dept Biosci Biotechnol & Biopharmaceut, Bari, Italy.
EM laura.vergani@unige.it; giuseppe.calamita@uniba.it
RI Grasselli, Elena/H-4304-2013; portincasa, piero/J-7245-2018; Baldini,
   Francesca/AAQ-3685-2020; Vergani, Laura/AAS-2711-2020; Serale,
   Nadia/KLY-5058-2024; Gena, patrizia/AAC-3396-2022
OI Calamita, Giuseppe/0000-0003-4666-9546; Serale,
   Nadia/0000-0002-5552-9361; Baldini, Francesca/0000-0002-6284-436X
FU Italian "Programmi di Ricerca Scientifica di Rilevante Interesse
   Nazionale 2017" (PRIN2017) [2017J92TM5]; University of Genova
FX We would like to thank Drs Rita Fabbri and Mohamad Khalil for the help
   with the experiments, Financial support to GC from Italian "Programmi di
   Ricerca Scientifica di Rilevante Interesse Nazionale 2017" (PRIN2017;
   grant #2017J92TM5) and to LV from University of Genova are gratefully
   acknowledged.
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NR 80
TC 28
Z9 31
U1 0
U2 34
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1388-1981
EI 1879-2618
J9 BBA-MOL CELL BIOL L
JI Biochim. Biophys. Acta Mol. Cell Biol. Lipids
PD MAR
PY 2020
VL 1865
IS 3
AR 158586
DI 10.1016/j.bbalip.2019.158586
PG 10
WC Biochemistry & Molecular Biology; Biophysics; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Cell Biology
GA KG3BD
UT WOS:000509816600004
PM 31816412
OA Green Published
DA 2025-06-11
ER

PT J
AU Soccolich, S
   Ridgeway, C
   Mabry, JE
   Camden, MC
   Miller, A
   Iridiastadi, H
   Hanowski, RJ
AF Soccolich, Susan
   Ridgeway, Christie
   Mabry, Jessica Erin
   Camden, Matthew C.
   Miller, Andrew
   Iridiastadi, Hardianto
   Hanowski, Richard J.
TI Challenges in Conducting Empirical Epidemiological Research with Truck
   and Bus Drivers in Diverse Settings in North America
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Review
DE truck research; bus research; epidemiological research; driver safety;
   driver health
ID URBAN TRANSIT OPERATORS; SLEEP-APNEA; METABOLIC SYNDROME; SELF-REPORTS;
   PREVALENCE; HEALTH; OBESITY; STRESS; RISK; HYPERTENSION
AB Over 6.5 million commercial vehicle drivers were operating a large truck or bus in the United States in 2020. This career often has high stress and long working hours, with few opportunities for physical activity. Previous research has linked these factors to adverse health conditions. Adverse health conditions affect not only the professional drivers' wellbeing but potentially also commercial motor vehicle (CMV) operators' safe driving ability and public safety for others sharing the roadway. The prevalence of health conditions with high impact on roadway safety in North American CMV drivers necessitates empirical epidemiological research to better understand and improve driver health. The paper presents four challenges in conducting epidemiological research with truck and bus drivers in North America and potential resolutions identified in past and current research. These challenges include (1) the correlation between driving performance, driving experience, and driver demographic factors; (2) the impact of medical treatment status on the relationship between health conditions and driver risk; (3) capturing accurate data in self-report data collection methods; and (4) reaching the CMV population for research. These challenges are common and influential in epidemiological research of this population, as drivers face severe health issues, health-related federal regulations, and the impact of vehicle operation on the safety of themselves and others using the roadways.
C1 [Soccolich, Susan; Ridgeway, Christie; Mabry, Jessica Erin; Camden, Matthew C.; Miller, Andrew; Iridiastadi, Hardianto; Hanowski, Richard J.] Virginia Tech Transportat Inst, Div Freight Transit & Heavy Vehicle Safety, Blacksburg, VA 24061 USA.
   [Iridiastadi, Hardianto] Inst Teknol Bandung, Fac Ind Technol, Bandung 40132, Indonesia.
C3 Virginia Polytechnic Institute & State University; Institute Technology
   of Bandung
RP Soccolich, S (corresponding author), Virginia Tech Transportat Inst, Div Freight Transit & Heavy Vehicle Safety, Blacksburg, VA 24061 USA.
EM ssoccolich@vtti.vt.edu
RI iridiastadi, hardianto/HPE-9633-2023; Camden, Matthew/AAH-9080-2021
OI Hanowski, Richard/0000-0002-3937-3061; Iridiastadi,
   Hardianto/0000-0002-5569-827X
FU Virginia Tech Open Access Subvention Fund
FX The research team would like to acknowledge support from the Virginia
   Tech Open Access Subvention Fund, which provided necessary funding to
   allow the research paper to be shared publicly in Open Access formats.
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NR 69
TC 3
Z9 3
U1 0
U2 7
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD OCT
PY 2022
VL 19
IS 19
AR 12494
DI 10.3390/ijerph191912494
PG 10
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA 5G1EG
UT WOS:000866748600001
PM 36231791
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Wang, H
   Zhu, JL
   Jia, Z
   Lu, SC
AF Wang, Hao
   Zhu, Jiali
   Jia, Zhe
   Lu, Sucai
TI Pretreatment of diabetic aged rats with combination of ginsenoside-Mc1
   and silibinin protects liver from ischemia-reperfusion injury through an
   AMPK-dependent mechanism
SO TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
LA English
DT Article
DE aging; diabetes; ginsenoside compound-Mc1; liver ischemia reperfusion
   injury; oxidative stress; silibinin
ID ISCHEMIA/REPERFUSION INJURY; METABOLIC SYNDROME; OXIDATIVE STRESS;
   GINSENG
AB Objectives This study evaluated the protective efficacy of combination treatment with ginsenoside-Mc1 and silibinin against hepatic ischemia-reperfusion (IR) injury in diabetic-aged rats, and further explored AMPK's role in this protection. Methods A high-fat diet/streptozotocin was used to induce type-2 diabetes in aged rats (20-24 months). Diabetic-aged rats were pretreated with ginsenoside-Mc1 (10 mg/kg, IP) and silibinin (50 mg/kg, IP), alone or in combination, for 4 weeks before induction of hepatic IR injury. Results Induction of IR injury in diabetic-aged rats significantly elevated plasma levels of hepatic alanine and aspartate aminotransferases and negatively affected liver histology. Levels of 8-isoprostane, ROS production, Bax, and cleaved-caspase-3 expression were higher and manganese-superoxide dismutase (MnSOD), glutathione, and Bcl2 and p-AMPK were lower in IR-receiving group. In comparison to individual treatments, the combination of ginsenoside-Mc1 and silibinin powerfully restored IR-induced changes in liver enzymes and histopathological indices, oxidative markers, AMPK, and apoptotic protein expressions. Inhibition of AMPK using compound-C in H2O2-stimulated HepG2 cells significantly abolished the protective effects of combination treatment. Conclusions Combination of ginsenoside-Mc1 and silibinin was superior to their alone usage in protecting hepatocytes of diabetic-aged rats from oxidative/apoptotic damages following IR injury, through an AMPK-mediated mechanism.
C1 [Lu, Sucai] Hebei Univ, Affiliated Hosp, Gastroenterol Dept, Baoding City 071030, Hebei, Peoples R China.
   [Wang, Hao; Zhu, Jiali; Jia, Zhe] Hebei Univ, Affiliated Hosp, Gastroenterol Dept, Baoding, Hebei, Peoples R China.
C3 Hebei University; Hebei University
RP Lu, SC (corresponding author), Hebei Univ, Affiliated Hosp, Gastroenterol Dept, Baoding City 071030, Hebei, Peoples R China.
EM lsc3065123@sina.com
RI wang, hao/HSE-7975-2023; ZHU, JIALI/JNE-3065-2023
FU TYHebei Provincial Government-funded Project for provincial Clinical
   Medical
FX TYHebei Provincial Government-funded Project for provincial Clinical
   Medical Talents in 2017.
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NR 33
TC 4
Z9 4
U1 0
U2 2
PU WALTER DE GRUYTER GMBH
PI BERLIN
PA GENTHINER STRASSE 13, D-10785 BERLIN, GERMANY
SN 0250-4685
EI 1303-829X
J9 TURK J BIOCHEM
JI Turk. J. Biochem.
PD MAR 8
PY 2022
VL 47
IS 1
BP 23
EP 32
DI 10.1515/tjb-2021-0010
EA JUN 2021
PG 10
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA ZP6CU
UT WOS:000740004300002
OA gold
DA 2025-06-11
ER

PT J
AU Lefranc, C
   Friederich-Persson, M
   Braud, L
   Palacios-Ramirez, R
   Karlsson, S
   Boujardine, N
   Motterlini, R
   Jaisser, F
   Cat, AND
AF Lefranc, Clara
   Friederich-Persson, Malou
   Braud, Laura
   Palacios-Ramirez, Roberto
   Karlsson, Susanne
   Boujardine, Nabiha
   Motterlini, Roberto
   Jaisser, Frederic
   Cat, Aurelie Nguyen Dinh
TI MR (Mineralocorticoid Receptor) Induces Adipose Tissue Senescence and
   Mitochondrial Dysfunction Leading to Vascular Dysfunction in Obesity
SO HYPERTENSION
LA English
DT Article
DE adipose tissue; aging; mitochondria; obesity; oxidative stress;
   sirtuins; vasoconstriction
ID SMOOTH-MUSCLE-CELLS; ADIPOCYTE DYSFUNCTION; PRIMARY ALDOSTERONISM;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; OXIDATIVE STRESS; FAT; SIRT1;
   ACTIVATION; EXPRESSION
AB Adipose tissue (AT) senescence and mitochondrial dysfunction are associated with obesity. Studies in obese patients and animals demonstrate that the MR (mineralocorticoid receptor) contributes to obesity-associated cardiovascular complications through its specific role in AT. However, underlying mechanisms remain unclear. This study aims to elucidate whether MR regulates mitochondrial function in obesity, resulting in AT premature aging and vascular dysfunction. Obese (db/db) and lean (db/+) mice were treated with an MR antagonist or a specific mitochondria-targeted antioxidant. Mitochondrial and vascular functions were determined by respirometry and myography, respectively. Molecular mechanisms were probed by Western immunoblotting and real-time polymerase chain reaction in visceral AT and arteries and focused on senescence markers and redox-sensitive pathways. db/db mice displayed AT senescence with activation of the p53-p21 pathway and decreased SIRT (sirtuin) levels, as well as mitochondrial dysfunction. Furthermore, the beneficial anticontractile effects of perivascular AT were lost in db/db via ROCK (Rho kinase) activation. MR blockade prevented these effects. Thus, MR activation in obesity induces mitochondrial dysfunction and AT senescence and dysfunction, which consequently increases vascular contractility. In conclusion, our study identifies novel mechanistic insights involving MR, adipose mitochondria, and vascular function that may be of importance to develop new therapeutic strategies to limit obesity-associated cardiovascular complications.
C1 [Lefranc, Clara; Palacios-Ramirez, Roberto; Boujardine, Nabiha; Jaisser, Frederic; Cat, Aurelie Nguyen Dinh] Sorbonne Univ, Ctr Rech Cordeliers, INSERM, Dept Physiol,UMRS 1138,Team 1, Paris, France.
   [Friederich-Persson, Malou; Karlsson, Susanne] Uppsala Univ, Dept Med Cell Biol, Uppsala, Sweden.
   [Braud, Laura; Motterlini, Roberto] Univ Paris Est Creteil, INSERM, Dept Pathophysiol Cardiovasc & Resp Dis, Dev & Senescence,U955,Team 12, Creteil, France.
C3 Universite Paris Cite; Institut National de la Sante et de la Recherche
   Medicale (Inserm); Sorbonne Universite; Uppsala University; Institut
   National de la Sante et de la Recherche Medicale (Inserm); Universite
   Paris-Est-Creteil-Val-de-Marne (UPEC)
RP Jaisser, F (corresponding author), Sorbonne Univ, Ctr Rech Cordeliers, INSERM, UMRS 1138,Team 1, 15 Rue Ecole Med, F-75006 Paris, France.
EM frederic.jaisser@inserm.fr
RI CAT, Aurelie/H-8182-2013; Motterlini, Roberto/Q-1890-2019;
   Palacios-Ramirez, Roberto/H-9905-2015; Motterlini, Roberto/G-2489-2013
OI Palacios-Ramirez, Roberto/0000-0002-0867-1277; BRAUD,
   Laura/0000-0002-8958-3817; Motterlini, Roberto/0000-0003-2684-2612;
   Lefranc, Clara/0000-0003-4635-136X
FU INSERM; CARMMA (Cardiac and Skeletal Muscle Alteration in Relation to
   Metabolic Diseases and Ageing: Role of Adipose Tissue) Avenir investment
   program [ANR-15-RHUS-0003]; Fondation de France [2014-00047968];
   European COST-ADMIRE network (European Cooperation in Science and
   TechnologiesAldosterone and Mineralocorticoid Receptor) [1301]; INSERM
   Poste d'Accueil fellowship; Wenner-Gren Foundations; Magnus Bergvall
   Foundation; Ake Wiberg Foundation
FX This work was made possible with funding from INSERM, CARMMA (Cardiac
   and Skeletal Muscle Alteration in Relation to Metabolic Diseases and
   Ageing: Role of Adipose Tissue) Avenir investment program
   (ANR-15-RHUS-0003), Fondation de France (2014-00047968), and the
   European COST-ADMIRE 1301 network (European Cooperation in Science and
   TechnologiesAldosterone and Mineralocorticoid Receptor). C. Lefranc is
   supported by an INSERM Poste d'Accueil fellowship. M. Friederich-Persson
   is supported by funding from the Wenner-Gren Foundations, the Magnus
   Bergvall Foundation and the Ake Wiberg Foundation.
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NR 54
TC 52
Z9 53
U1 0
U2 12
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0194-911X
EI 1524-4563
J9 HYPERTENSION
JI Hypertension
PD FEB
PY 2019
VL 73
IS 2
BP 458
EP 468
DI 10.1161/HYPERTENSIONAHA.118.11873
PG 11
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA HO9XK
UT WOS:000461318900033
PM 30624990
OA Green Submitted, Bronze
DA 2025-06-11
ER

PT J
AU Escasany, E
   Izquierdo-Lahuerta, A
   Medina-Gomez, G
AF Escasany, Elia
   Izquierdo-Lahuerta, Adriana
   Medina-Gomez, Gema
TI Underlying Mechanisms of Renal Lipotoxicity in Obesity
SO NEPHRON
LA English
DT Review
DE Obesity; Adipose tissue expandability; Lipotoxicity; Peroxisome
   proliferator-activated receptor gamma; Chronic kidney disease
ID METABOLIC SYNDROME; ADIPOSE-TISSUE; PODOCYTE; DISEASE; TROGLITAZONE;
   STRESS
AB The recent and ongoing worldwide increase in the prevalence of obesity parallels the increase in the incidence of chronic kidney disease (CKD). This association suggests an implication of lipotoxicity in the development of kidney diseases. The increased influx of lipids into the kidney can be explained in the context of the Adipose Tissue Expandability Hypothesis. This hypothesis states that the adipose tissue has a limited expansion capability, which is different for each individual, and once this limit is reached, the adipose tissue cannot store any more lipids and will thus release them into the bloodstream. The accumulation of lipids in the kidney is known as renal lipotoxicity. Renal lipotoxicity is known to cause detrimental effects on the kidney by several mechanisms of action including reclusion of pro-inflammatory factors, oxidative and ER stress development, insulin resistance (IR), lipid metabolism deregulation or renin-angiotensin aldosterone system overactivation. Isoform peroxisome proliferator-activated receptor gamma (PPAR gamma) seems to play an important role in the development of this lipotoxicity as proven by several studies in animals and cultured cells. Thus, PPAR gamma agonists are of interest in the therapeutic approach to treat CKD in the context of obesity. This review aims to summarize our current knowledge of the mechanism by which lipotoxicity affects renal structure and function using in vivo and in vitro models as examples focusing on PPAR gamma. (C) 2019 S. Karger AG, Basel
C1 [Escasany, Elia; Izquierdo-Lahuerta, Adriana; Medina-Gomez, Gema] Univ Rey Juan Carlos, Area Bioquim & Biol Mol, Dept Ciencias Basicas Salud, Fac Ciencias Salud, Ave Atenas S-N, ES-28922 Madrid, Spain.
C3 Universidad Rey Juan Carlos
RP Medina-Gomez, G (corresponding author), Univ Rey Juan Carlos, Area Bioquim & Biol Mol, Dept Ciencias Basicas Salud, Fac Ciencias Salud, Ave Atenas S-N, ES-28922 Madrid, Spain.
EM gema.medina@urjc.es
RI Medina-Gomez, Gema/F-5667-2016; Escasany, Elia/G-9383-2018
OI Medina-Gomez, Gema/0000-0001-8169-681X; Escasany,
   Elia/0000-0002-4589-8219
FU Ministerio de Economia y Competitividad [BFU2013-47384-R,
   BFU2016-78951-R]; Comunidad de Madrid [S2010/BMD-2423, B2017BMD-368]
FX Research conducted for this publication was supported by Ministerio de
   Economia y Competitividad (BFU2013-47384-R and BFU2016-78951-R) and
   Comunidad de Madrid (S2010/BMD-2423 and B2017BMD-368), Spain.
CR Arima S, 2002, J AM SOC NEPHROL, V13, P342, DOI 10.1681/ASN.V132342
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NR 21
TC 53
Z9 58
U1 0
U2 8
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1660-8151
EI 2235-3186
J9 NEPHRON
JI Nephron
PY 2019
VL 143
IS 1
BP 28
EP 32
DI 10.1159/000494694
PG 5
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA IW0QZ
UT WOS:000484668900007
PM 30625473
OA Bronze
DA 2025-06-11
ER

PT J
AU Cheng, ZH
   Qiao, DL
   Zhao, SM
   Zhang, BJ
   Lin, QL
   Xie, FW
AF Cheng, Zihang
   Qiao, Dongling
   Zhao, Siming
   Zhang, Binjia
   Lin, Qinlu
   Xie, Fengwei
TI Whole grain rice: Updated understanding of starch digestibility and the
   regulation of glucose and lipid metabolism
SO COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY
LA English
DT Review
DE whole grain rice; starch digestibility; starch gelatinization; glycemic
   index; glucose metabolism; lipid metabolism; mechanisms
ID GERMINATED BROWN RICE; HIGH-FAT DIET; ORYZA-SATIVA L.;
   GAMMA-AMINOBUTYRIC-ACID; ENDOPLASMIC-RETICULUM STRESS; GASTRIC DIGESTION
   SIMULATOR; POSTPRANDIAL BLOOD-GLUCOSE; FREEZE-THAW CYCLE; WHITE RICE;
   IN-VITRO
AB Nowadays, resulting from disordered glucose and lipid metabolism, metabolic diseases (e.g., hyperglycemia, type 2 diabetes, and obesity) are among the most serious health issues facing humans worldwide. Increasing evidence has confirmed that dietary intervention (with healthy foods) is effective at regulating the metabolic syndrome. Whole grain rice (WGR) rich in dietary fiber and many bioactive compounds (e.g., gamma-amino butyric acid, gamma-oryzanol, and polyphenols) can not only inhibit starch digestion and prevent rapid increase in the blood glucose level, but also reduce oxidative stress and damage to the liver, thereby regulating glucose and lipid metabolism. The rate of starch digestion is directly related to the blood glucose level in the organism after WGR intake. Therefore, the effects of different factors (e.g., additives, cooking, germination, and physical treatments) on WGR starch digestibility are examined in this review. In addition, the mechanisms from human and animal experiments regarding the correlation between the intake of WGR or its products and the lowered blood glucose and lipid levels and the reduced incidence of diabetes and obesity are discussed. Moreover, information on developing WGR products with the health benefits is provided.
C1 [Cheng, Zihang; Zhao, Siming; Zhang, Binjia] Huazhong Agr Univ, Coll Food Sci & Technol, Grp Cereals & Oils Proc, Minist Educ,Key Lab Environm Correlat Dietol, Wuhan, Peoples R China.
   [Qiao, Dongling] Hubei Univ Technol, Sch Food & Biol Engn, HBUT, Glyn O Phillips Hydrocolloid Res Ctr, Wuhan, Peoples R China.
   [Lin, Qinlu] Cent South Univ Forestry & Technol, Natl Engn Lab Rice & Prod Deep Proc, Changsha, Peoples R China.
   [Xie, Fengwei] Newcastle Univ, Sch Engn, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England.
C3 Ministry of Education - China; Huazhong Agricultural University; Hubei
   University of Technology; Central South University of Forestry &
   Technology; Newcastle University - UK
RP Xie, FW (corresponding author), Newcastle Univ, Sch Engn, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England.; Zhang, BJ (corresponding author), Huazhong Agr Univ, Coll Food Sci & Technol, 1 Shizishan St, Wuhan 430070, Hubei, Peoples R China.
EM zhangbj@mail.hzau.edu.cn; david.xie@newcastle.ac.uk
RI cheng, zihang/GYV-0247-2022; Xie, David Fengwei/B-4747-2009; Lin,
   Qinlu/B-1732-2019
OI Xie, David Fengwei/0000-0002-2033-082X; Cheng,
   Zihang/0009-0000-0051-4560; Lin, Qinlu/0000-0003-2043-4220
FU China Association for Science and Technology [2018QNRC001]
FX China Association for Science and Technology, Grant/Award Number:
   2018QNRC001
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NR 188
TC 29
Z9 31
U1 19
U2 221
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1541-4337
J9 COMPR REV FOOD SCI F
JI Compr. Rev. Food. Sci. Food Saf.
PD JUL
PY 2022
VL 21
IS 4
BP 3244
EP 3273
DI 10.1111/1541-4337.12985
EA JUN 2022
PG 30
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA 3D1GZ
UT WOS:000808439600001
PM 35686475
OA hybrid
DA 2025-06-11
ER

PT J
AU Mehmood, A
   Zhao, L
   Wang, CT
   Hossen, I
   Raka, RN
   Zhang, HM
AF Mehmood, Arshad
   Zhao, Lei
   Wang, Chengtao
   Hossen, Imam
   Raka, Rifat Nowshin
   Zhang, Huimin
TI Stevia residue extract increases intestinal uric acid excretion
   via interactions with intestinal urate transporters in
   hyperuricemic mice
SO FOOD & FUNCTION
LA English
DT Article
ID GLUTATHIONE DEPLETION; REBAUDIANA BERTONI; METABOLIC SYNDROME; OXIDATIVE
   STRESS; ANTIOXIDANT; STEVIOSIDE; INHIBITION; SWEETENER; OXIDASE; LEAVES
AB Hyperuricemia (HUA) is a metabolic disorder that occurs due to the overproduction or under-excretion of uric acid (UA) and is directly linked to the development of many life-threatening diseases. There is a growing interest among many researchers regarding how to overcome the encumbrance of HUA because conventional drugs are associated with multiple side effects. Thus, the present project has been designed to utilize flavonoids and chlorogenic acid-enriched stevia residue extract (STVRE) to combat HUA. The results show that supplementation with STVRE (200 and 400 mg per kg bw) inhibits the XOD enzyme in serum, duodenum, jejunum, and ileum tissues. Moreover, UA levels in the STVRE groups were also significantly (p < 0.05) decreased in serum, duodenum, jejunum, and ileum tissues and juices. STVRE also improved the intestinal morphology and oxidative biomarkers in duodenum, jejunum, and ileum tissues. Protein and mRNA expressions of ABCG2 were upregulated, whereas GLUT9 was downregulated in the STVRE-treated groups as compared with the model control group. The supplementation of STVRE significantly attenuated hyperuricemia and oxidative stress, upregulated ABCG2 and downregulated GLUT9 (protein and mRNA) expression in hyperuricemic mice. The results of our study revealed that the by-product of stevia has the potential to combat hyperuricemia, and can be used as a functional ingredient in the development of nutraceutical products.
C1 [Mehmood, Arshad; Zhao, Lei; Wang, Chengtao; Hossen, Imam; Raka, Rifat Nowshin; Zhang, Huimin] Beijing Technol & Business Univ, Beijing Adv Innovat Ctr Food Nutr & Human Hlth, Beijing 100048, Peoples R China.
   [Mehmood, Arshad; Zhao, Lei; Wang, Chengtao; Hossen, Imam; Raka, Rifat Nowshin; Zhang, Huimin] Beijing Technol & Business Univ, Beijing Engn & Technol Res Ctr Food Additives, Sch Food & Chem Technol, Beijing 100048, Peoples R China.
C3 Beijing Technology & Business University; Beijing Technology & Business
   University
RP Zhao, L; Wang, CT (corresponding author), Beijing Technol & Business Univ, Beijing Adv Innovat Ctr Food Nutr & Human Hlth, Beijing 100048, Peoples R China.; Zhao, L; Wang, CT (corresponding author), Beijing Technol & Business Univ, Beijing Engn & Technol Res Ctr Food Additives, Sch Food & Chem Technol, Beijing 100048, Peoples R China.
EM zhaolei@th.btbu.edu.cn; wangchengtaojs@163.com
RI Zhao, Lei/AAS-2428-2021; Qureshi, Arshad/AAG-6954-2019; Hossen,
   Imam/KDO-9990-2024; NOWSHIN, RAKA/IXN-6327-2023; Mehmood,
   Arshad/W-5172-2017
OI Raka, Rifat Nowshin/0000-0002-3337-5605; Mehmood,
   Arshad/0000-0002-2022-375X; Hossen, Imam/0000-0002-4574-6995
FU National key research and development program [2018YFD0400403,
   2016YFD0400802]; Talent Training Quality Construction-First Class
   Professional Construction [PXM2019-014213-000010]; BTBU Basic Scientific
   Research Operating Fee in 2019 [PXM2019-014213-000010,
   PXM2019-014213-000007]; High-level Teachers in Beijing Municipal
   Universities in the Period of 13th Five-year Plan [CITTCD201704042];
   Beijing Advanced Innovation Center for Food Nutrition and Human Health
FX This work was supported by the National key research and development
   program (Grant No. 2018YFD0400403 and 2016YFD0400802), Talent Training
   Quality Construction-First Class Professional Construction (Grant No.
   PXM2019-014213-000010), BTBU Basic Scientific Research Operating Fee in
   2019 (Grant No. PXM2019-014213-000010 and PXM2019-014213-000007),
   High-level Teachers in Beijing Municipal Universities in the Period of
   13th Five-year Plan (Grant No. CIT&TCD201704042) and Beijing Advanced
   Innovation Center for Food Nutrition and Human Health. The author Arshad
   Mehmood would like to thanks, Muhammad ishaq, Oumeddour Dounya Zad,
   Muhammad Naveed, Goutom Kumar Gaine, Karim A. H. M. Minhazul, Afroza
   Tahamina, and Md. Arif Hossain for helping in the animal dissection.
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TC 32
Z9 34
U1 3
U2 67
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PD DEC 1
PY 2019
VL 10
IS 12
BP 7900
EP 7912
DI 10.1039/c9fo02032b
PG 13
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA KD1PE
UT WOS:000507643700025
PM 31789332
DA 2025-06-11
ER

PT J
AU Yoshihara, T
   Morimoto, T
   Hirata, H
   Murayama, M
   Nonaka, T
   Tsukamoto, M
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AF Yoshihara, Tomohito
   Morimoto, Tadatsugu
   Hirata, Hirohito
   Murayama, Masatoshi
   Nonaka, Toshihiro
   Tsukamoto, Masatsugu
   Toda, Yu
   Kobayashi, Takaomi
   Izuhara, Kenji
   Mawatari, Masaaki
TI Mechanisms of tissue degeneration mediated by periostin in spinal
   degenerative diseases and their implications for pathology and
   diagnosis: a review
SO FRONTIERS IN MEDICINE
LA English
DT Review
DE periostin; pathway; biomarker; mechanical stress; inflammation; spinal
   degenerative diseases; bone metabolic diseases
ID LIGAMENTUM-FLAVUM HYPERTROPHY; INTERVERTEBRAL DISC DEGENERATION;
   NF-KAPPA-B; SERUM PERIOSTIN; KNEE OSTEOARTHRITIS; TNF-ALPHA;
   PERIODONTAL-LIGAMENT; POSTMENOPAUSAL WOMEN; GENE-EXPRESSION; BONE LOSS
AB Periostin (POSTN) serves a dual role as both a matricellular protein and an extracellular matrix (ECM) protein and is widely expressed in various tissues and cells. As an ECM protein, POSTN binds to integrin receptors, transduces signals to cells, enabling cell activation. POSTN has been linked with various diseases, including atopic dermatitis, asthma, and the progression of multiple cancers. Recently, its association with orthopedic diseases, such as osteoporosis, osteoarthritis resulting from cartilage destruction, degenerative diseases of the intervertebral disks, and ligament degenerative diseases, has also become apparent. Furthermore, POSTN has been shown to be a valuable biomarker for understanding the pathophysiology of orthopedic diseases. In addition to serum POSTN, synovial fluid POSTN in joints has been reported to be useful as a biomarker. Risk factors for spinal degenerative diseases include aging, mechanical stress, trauma, genetic predisposition, obesity, and metabolic syndrome, but the cause of spinal degenerative diseases (SDDs) remains unclear. Studies on the pathophysiological effects of POSTN may significantly contribute toward the diagnosis and treatment of spinal degenerative diseases. Therefore, in this review, we aim to examine the mechanisms of tissue degeneration caused by mechanical and inflammatory stresses in the bones, cartilage, intervertebral disks, and ligaments, which are crucial components of the spine, with a focus on POSTN.
C1 [Yoshihara, Tomohito; Morimoto, Tadatsugu; Hirata, Hirohito; Murayama, Masatoshi; Nonaka, Toshihiro; Tsukamoto, Masatsugu; Toda, Yu; Kobayashi, Takaomi; Mawatari, Masaaki] Saga Univ, Fac Med, Dept Orthopaed Surg, Saga, Japan.
   [Izuhara, Kenji] Saga Med Sch, Dept Biomol Sci, Div Med Biochem, Saga, Japan.
C3 Saga University; Saga University
RP Morimoto, T (corresponding author), Saga Univ, Fac Med, Dept Orthopaed Surg, Saga, Japan.
EM morimot3@cc.saga-u.ac.jp
RI Kobayashi, Takaomi/AAM-2250-2021; morimoto, tadatsugu/ABD-1512-2020;
   Izuhara, Kenji/LVR-6471-2024; TODA, Yoshiaki/U-7601-2019
OI Murayama, Masatoshi/0009-0000-1228-482X; morimoto,
   tadatsugu/0000-0002-3359-9684
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NR 206
TC 4
Z9 4
U1 2
U2 9
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 2296-858X
J9 FRONT MED-LAUSANNE
JI Front. Med.
PD OCT 31
PY 2023
VL 10
AR 1276900
DI 10.3389/fmed.2023.1276900
PG 18
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA X9SQ9
UT WOS:001101770200001
PM 38020106
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Ghobadi, H
   Abdollahi, N
   Madani, H
   Aslani, MR
AF Ghobadi, Hassan
   Abdollahi, Nasim
   Madani, Hanieh
   Aslani, Mohammad Reza
TI Effect of Crocin From Saffron (Crocus sativus L.) Supplementation
   on Oxidant/Antioxidant Markers, Exercise Capacity, and Pulmonary
   Function Tests in COPD Patients: A Randomized, Double-Blind,
   Placebo-Controlled Trial
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Article
DE crocin; oxidative stress; COPD; 6MWD (6minute walking distance); NF-kB
ID NF-KAPPA-B; PIG TRACHEAL CHAINS; QUALITY-OF-LIFE; OXIDATIVE STRESS;
   METABOLIC SYNDROME; ANTIOXIDANT; ASTHMA; PATHOGENESIS; INFLAMMATION;
   MECHANISMS
AB Background: Chronic obstructive pulmonary disease (COPD) is a progressive and chronic respiratory disorder characterized by reversible airflow limitation and lung parenchyma destruction. The main feature of COPD is inflammation and disturbance of the oxidant/antioxidant balance in the airways. The therapeutic use of herbal supplements with antioxidant and anti-inflammatory properties seems to be very useful in the medical management of patients with COPD.
   Method: COPD patients were divided into placebo and intervention groups (each group n = 23) in a clinical trial study. The intervention group received crocin supplementation (30 mg/day for 12 weeks), and the control group received a placebo. Pre- and after the intervention, pulmonary function tests (PFTs), exercise capacity (using a 6-min walking distance test (6MWD)), and serum levels of total oxidant status (TOS), total antioxidant capacity (TAOC), and NF-kB were assessed using the ELISA test.
   Results: Intervention with crocin for 12 weeks in COPD patients decreased serum levels of TOS and NF-kappa B as well as increased TAOC. In addition, the results of the 6MWD test reveal an improvement in patients' exercise capacity.
   Conclusion: Crocin supplementation appears to effectively establish oxidant/antioxidant balance and improve inflammatory conditions in patients with COPD.
C1 [Ghobadi, Hassan; Aslani, Mohammad Reza] Ardabil Univ Med Sci, Lung Dis Res Ctr, Ardebil, Iran.
   [Ghobadi, Hassan; Abdollahi, Nasim] Ardabil Univ Med Sci, Dept Internal Med, Fac Med, Ardebil, Iran.
   [Madani, Hanieh] Ardabil Univ Med Sci, Fac Med, Ardebil, Iran.
   [Aslani, Mohammad Reza] Mashhad Univ Med Sci, Appl Biomed Res Ctr, Mashhad, Razavi Khorasan, Iran.
C3 Ardabil University of Medical Sciences; Ardabil University of Medical
   Sciences; Ardabil University of Medical Sciences; Mashhad University of
   Medical Sciences
RP Aslani, MR (corresponding author), Ardabil Univ Med Sci, Lung Dis Res Ctr, Ardebil, Iran.; Aslani, MR (corresponding author), Mashhad Univ Med Sci, Appl Biomed Res Ctr, Mashhad, Razavi Khorasan, Iran.
EM mraslani105@yahoo.com
RI ghobadi, hassan/J-5241-2017; Aslani, Mohammad Reza/J-3566-2017
OI Aslani, Mohammad Reza/0000-0003-1519-7611
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NR 53
TC 24
Z9 24
U1 3
U2 6
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD APR 20
PY 2022
VL 13
AR 884710
DI 10.3389/fphar.2022.884710
PG 10
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 1V4ZM
UT WOS:000806099700001
PM 35517806
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Diane, A
   Abunada, H
   Khattab, N
   Moin, AM
   Butler, AE
   Dehbi, M
AF Diane, Abdoulaye
   Abunada, Hanan
   Khattab, Namat
   Moin, Abu Saleh Md
   Butler, Alexandra E.
   Dehbi, Mohammed
TI Role of the DNAJ/HSP40 family in the pathogenesis of insulin resistance
   and type 2 diabetes
SO AGEING RESEARCH REVIEWS
LA English
DT Review
DE Insulin resistance; Type 2 diabetes; Heat shock proteins; Molecular
   chaperones; Metabolic stress; ?-cell function
ID ENDOPLASMIC-RETICULUM STRESS; HEAT-SHOCK PROTEINS; BETA-CELL
   DYSFUNCTION; B KINASE COMPLEX; SKELETAL-MUSCLE; RECEPTOR SUBSTRATE-1;
   LIPOSOMAL DELIVERY; PANCREATIC-ISLETS; ATPASE ACTIVITY; MESSENGER-RNA
AB Insulin resistance (IR) underpins a wide range of metabolic disorders including type 2 diabetes (T2D), metabolic syndrome and cardiovascular diseases. IR is characterized by a marked reduction in the magnitude and/or delayed onset of insulin to stimulate glucose disposal. This condition is due to defects in one or several intracellular intermediates of the insulin signaling cascade, ranging from insulin receptor substrate (IRS) inactivation to reduced glucose phosphorylation and oxidation. Genetic predisposition, as well as other precipitating factors such as aging, obesity, and sedentary lifestyles are among the risk factors underlying the pathogenesis of IR and its subsequent progression to T2D. One of the cardinal hallmarks of T2D is the impairment of the heat shock response (HSR). Human and animal studies provided compelling evidence of reduced expression of several components of the HSR (i.e. Heat shock proteins or HSPs) in diabetic samples in a manner that correlates with the degree of IR. Interventions that induce the HSR, irrespective of the means to achieve it, proved their effectiveness in enhancing insulin sensitivity and improving glycemic index. However, most of these studies have been focused on HSP70 family. In this review, we will focus on the novel role of DNAJ/HSP40 cochaperone family in metabolic diseases associated with IR.
C1 [Diane, Abdoulaye; Abunada, Hanan; Khattab, Namat; Moin, Abu Saleh Md; Butler, Alexandra E.; Dehbi, Mohammed] Hamad Bin Khalifa Univ HBKU, Qatar Fdn QF, Diabet Res Ctr DRC, Qatar Biomed Res Inst QBRI, POB 34110, Doha, Qatar.
C3 Qatar Foundation (QF); Hamad Bin Khalifa University-Qatar; Qatar
   Biomedical Research Institute (QBRI)
RP Butler, AE (corresponding author), Hamad Bin Khalifa Univ HBKU, Qatar Fdn QF, Diabet Res Ctr DRC, Qatar Biomed Res Inst QBRI, POB 34110, Doha, Qatar.
EM adiane@hbku.edu.qa; hanan.nada85@gmail.com; namatk@hotmail.com;
   amoin@hbku.edu.qa; abutler@hbku.edu.qa; mdehbi_ksa@hotmail.com
RI MOIN, ABU SALEH MD/AAY-2498-2021
OI Butler, Alexandra/0000-0002-5762-3917; Abunada,
   Hanan/0000-0003-2186-2518
FU Qatar Biomedical Research Institute/Hamad Bin Khalifa University
FX We are indebted to the group of scientific community working on the role
   of HSR in the pathogenesis of metabolic diseases associated with IR for
   shedding light on the importance of manipulating this crucial host
   defense to fight against this devastating disease. We did our best to
   cite all the relevant references and we apologize for any missed work.
   This study was supported by an intramural grant from Qatar Biomedical
   Research Institute/Hamad Bin Khalifa University to MD.
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NR 126
TC 15
Z9 16
U1 0
U2 13
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 1568-1637
EI 1872-9649
J9 AGEING RES REV
JI Ageing Res. Rev.
PD MAY
PY 2021
VL 67
AR 101313
DI 10.1016/j.arr.2021.101313
EA MAR 2021
PG 11
WC Cell Biology; Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Geriatrics & Gerontology
GA RF5FR
UT WOS:000634864600006
PM 33676026
DA 2025-06-11
ER

PT J
AU Kang, GG
   Francis, N
   Hill, R
   Waters, D
   Blanchard, C
   Santhakumar, AB
AF Kang, Gideon Gatluak
   Francis, Nidhish
   Hill, Rodney
   Waters, Daniel
   Blanchard, Christopher
   Santhakumar, Abishek Bommannan
TI Dietary Polyphenols and Gene Expression in Molecular Pathways Associated
   with Type 2 Diabetes Mellitus: A Review
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE polyphenols; type 2 diabetes; pancreatic beta-cell function; insulin
   resistance; gene expression
ID SUPPRESSES HEPATIC GLUCONEOGENESIS; PANCREATIC BETA-CELLS; GREEN TEA
   POLYPHENOL; INSULIN-RESISTANCE; OXIDATIVE STRESS; PROTEIN-KINASE;
   RESVERATROL SUPPLEMENTATION; EPIGALLOCATECHIN GALLATE; ANTIOXIDANT
   PROPERTIES; METABOLIC SYNDROME
AB Type 2 diabetes mellitus (T2DM) is a complex metabolic disorder with various contributing factors including genetics, epigenetics, environment and lifestyle such as diet. The hallmarks of T2DM are insulin deficiency (also referred to as beta-cell dysfunction) and insulin resistance. Robust evidence suggests that the major mechanism driving impaired beta-cell function and insulin signalling is through the action of intracellular reactive oxygen species (ROS)-induced stress. Chronic high blood glucose (hyperglycaemia) and hyperlipidaemia appear to be the primary activators of these pathways. Reactive oxygen species can disrupt intracellular signalling pathways, thereby dysregulating the expression of genes associated with insulin secretion and signalling. Plant-based diets, containing phenolic compounds, have been shown to exhibit remedial benefits by ameliorating insulin secretion and insulin resistance. The literature also provides evidence that polyphenol-rich diets can modulate the expression of genes involved in insulin secretion, insulin signalling, and liver gluconeogenesis pathways. However, whether various polyphenols and phenolic compounds can target specific cellular signalling pathways involved in the pathogenesis of T2DM has not been elucidated. This review aims to evaluate the modulating effects of various polyphenols and phenolic compounds on genes involved in cellular signalling pathways (both in vitro and in vivo from human, animal and cell models) leading to the pathogenesis of T2DM.
C1 [Kang, Gideon Gatluak; Francis, Nidhish; Waters, Daniel; Blanchard, Christopher; Santhakumar, Abishek Bommannan] ARC, Ind Transformat Training Ctr ITTC Funct Grains, Graham Ctr Agr Innovat, Wagga Wagga, NSW 2650, Australia.
   [Kang, Gideon Gatluak; Hill, Rodney; Waters, Daniel; Blanchard, Christopher; Santhakumar, Abishek Bommannan] Charles Sturt Univ, Sch Biomed Sci, Wagga Wagga, NSW 2650, Australia.
   [Francis, Nidhish] Charles Sturt Univ, Sch Anim & Vet Sci, Wagga Wagga, NSW 2650, Australia.
C3 Charles Sturt University; Charles Sturt University
RP Santhakumar, AB (corresponding author), ARC, Ind Transformat Training Ctr ITTC Funct Grains, Graham Ctr Agr Innovat, Wagga Wagga, NSW 2650, Australia.; Santhakumar, AB (corresponding author), Charles Sturt Univ, Sch Biomed Sci, Wagga Wagga, NSW 2650, Australia.
EM gkang@csu.edu.au; nfrancis@csu.edu.au; rhill@csu.edu.au;
   dwaters@csu.edu.au; cblanchard@csu.edu.au; asanthakumar@csu.edu.au
RI Santhakumar, Abishek/B-6700-2017; Francis, Nidhish/AAX-3068-2020; Hill,
   Rodney/C-4106-2012; Blanchard, Christopher/P-5124-2016
OI Francis, Nidhish/0000-0002-9475-2144; Kang, Gideon/0000-0003-1052-0811;
   Waters, Daniel/0000-0002-8622-3162; Blanchard,
   Christopher/0000-0001-5800-4678
FU Graham Centre for Agricultural Innovation, Australia; Faculty of
   Science, Charles Sturt University
FX This work was supported by the Graham Centre for Agricultural
   Innovation, Australia. We also acknowledge the financial support
   provided by the Faculty of Science, Charles Sturt University, to cover
   the publication costs.
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NR 157
TC 103
Z9 105
U1 5
U2 62
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD JAN 1
PY 2020
VL 21
IS 1
AR 140
DI 10.3390/ijms21010140
PG 26
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA KO2KF
UT WOS:000515378000140
PM 31878222
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Yang, KY
   Gotzmann, J
   Kuny, S
   Huang, H
   Sauvé, Y
   Chan, CB
AF Yang, Kaiyuan
   Gotzmann, Jonathan
   Kuny, Sharee
   Huang, Hui
   Sauve, Yves
   Chan, Catherine B.
TI Five stages of progressive β-cell dysfunction in the laboratory Nile rat
   model of type 2 diabetes
SO JOURNAL OF ENDOCRINOLOGY
LA English
DT Article
DE insulin resistance; type 2 diabetes; animal model; insulin processing;
   endoplasmic reticulum stress
ID UNFOLDED PROTEIN RESPONSE; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   ANIMAL-MODELS; FAILURE; GLUCOSE; PROINSULIN; DIET; MASS; MECHANISM
AB We compared the evolution of insulin resistance, hyperglycemia, and pancreatic beta-cell dysfunction in the Nile rat (Arvicanthis niloticus), a diurnal rodent model of spontaneous type 2 diabetes (T2D), when maintained on regular laboratory chow versus a high-fiber diet. Chow-fed Nile rats already displayed symptoms characteristic of insulin resistance at 2 months (increased fat/lean mass ratio and hyperinsulinemia). Hyperglycemia was first detected at 6 months, with increased incidence at 12 months. By this age, pancreatic islet structure was disrupted (increased a-cell area), insulin secretion was impaired (reduced insulin secretion and content) in isolated islets, insulin processing was compromised (accumulation of proinsulin and C-peptide inside islets), and endoplasmic reticulum (ER) chaperone protein ERp44 was upregulated in insulin-producing beta-cells. By contrast, high-fiber-fed Nile rats had normoglycemia with compensatory increase in beta-cell mass resulting in maintained pancreatic function. Fasting glucose levels were predicted by the alpha/beta-cell ratios. Our results show that Nile rats fed chow recapitulate the five stages of progression of T2D as occurs in human disease, including insulin-resistant hyperglycemia and pancreatic islet beta-cell dysfunction associated with ER stress. Modification of diet alone permits long-term beta-cell compensation and prevents T2D.
C1 [Yang, Kaiyuan; Chan, Catherine B.] Univ Alberta, Dept Agr Food & Nutr Sci, Edmonton, AB, Canada.
   [Gotzmann, Jonathan; Huang, Hui; Sauve, Yves; Chan, Catherine B.] Univ Alberta, Dept Physiol, Edmonton, AB, Canada.
   [Kuny, Sharee; Sauve, Yves] Univ Alberta, Dept Ophthalmol & Visual Sci, Edmonton, AB, Canada.
C3 University of Alberta; University of Alberta; University of Alberta
RP Sauvé, Y (corresponding author), Univ Alberta, Dept Physiol, Edmonton, AB, Canada.; Sauvé, Y (corresponding author), Univ Alberta, Dept Ophthalmol & Visual Sci, Edmonton, AB, Canada.
EM ysauve@ualberta.ca
RI Chan, Catherine/C-1162-2011; Yang, Kaiyuan/T-7575-2017
OI Huang, Hui/0000-0002-5823-8658
FU Canadian Institutes of Health Research (CIHR) [MOP 125873]; China
   Scholarship Council; Alberta Diabetes Institute
FX This work was supported by the Canadian Institutes of Health Research
   (CIHR; MOP 125873) to Y S and C B C. Y S is an AHFMR senior scholar
   (200800242); K Y and H H are recipients of scholarships from China
   Scholarship Council; J G is recipient of a scholarship from the Alberta
   Diabetes Institute.
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NR 41
TC 26
Z9 29
U1 0
U2 2
PU BIOSCIENTIFICA LTD
PI BRISTOL
PA EURO HOUSE, 22 APEX COURT WOODLANDS, BRADLEY STOKE, BRISTOL BS32 4JT,
   ENGLAND
SN 0022-0795
EI 1479-6805
J9 J ENDOCRINOL
JI J. Endocrinol.
PD JUN
PY 2016
VL 229
IS 3
BP 343
EP 356
DI 10.1530/JOE-15-0517
PG 14
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA DQ7JX
UT WOS:000379384500017
PM 27068697
OA Bronze
DA 2025-06-11
ER

PT J
AU Zhang, RJ
   Yu, Y
   Deng, JJ
   Zhang, C
   Zhang, JH
   Cheng, Y
   Luo, XQ
   Han, B
   Yang, HX
AF Zhang, Ruijuan
   Yu, Yan
   Deng, Jianjun
   Zhang, Chao
   Zhang, Jinghua
   Cheng, Yue
   Luo, Xiaoqin
   Han, Bei
   Yang, Haixia
TI Sesamin Ameliorates High-Fat Diet-Induced Dyslipidemia and Kidney Injury
   by Reducing Oxidative Stress
SO NUTRIENTS
LA English
DT Article
DE hyperlipidemia; lipid-induced kidney injury; oxidative stress; sesamin
ID EPITHELIAL-MESENCHYMAL TRANSITION; RENAL-DISEASE; LIPID NEPHROTOXICITY;
   METABOLIC SYNDROME; DOWN-REGULATION; INHIBITION; OIL; DYSFUNCTION;
   OBESITY; LIVER
AB The study explored the protective effect of sesamin against lipid-induced renal injury and hyperlipidemia in a rat model. An animal model of hyperlipidemia was established in Sprague-Dawley rats. Fifty-five adult Sprague-Dawley rats were divided into five groups. The control group was fed a standard diet, while the other four groups were fed a high-fat diet for 5 weeks to induce hyperlipidemia. Three groups received oral sesamin in doses of 40, 80, or 160 mg/(kg.day). Seven weeks later, the blood lipids, renal function, antioxidant enzyme activities, and hyperoxide levels in kidney tissues were measured. The renal pathological changes and expression levels of collagen type IV (Col-IV) and alpha-smooth muscle actin (alpha-SMA) were analyzed. The administration of sesamin improved the serum total cholesterol, triglyceride, low-density lipoprotein cholesterol, apolipoprotein-B, oxidized-low-density lipoprotein, and serum creatinine levels in hyperlipidemic rats, while it increased the high-density lipoprotein cholesterol and apolipoprotein-A levels. Sesamin reduced the excretion of 24-h urinary protein and urinary albumin and downregulated alpha-SMA and Col-IV expression. Moreover, sesamin ameliorated the superoxide dismutase activity and reduced malondialdehyde levels in kidney tissue. Sesamin could mediate lipid metabolism and ameliorate renal injury caused by lipid metabolism disorders in a rat model of hyperlipidemia.
C1 [Zhang, Ruijuan; Yu, Yan; Zhang, Chao; Zhang, Jinghua; Cheng, Yue; Luo, Xiaoqin; Han, Bei; Yang, Haixia] Xi An Jiao Tong Univ, Dept Nutr & Food Safety, Sch Publ Hlth, Xian 710061, Peoples R China.
   [Deng, Jianjun] NW Univ Xian, Shaanxi Key Lab Degradable Biomed Mat, Dept Food Sci & Engn, Coll Chem Engn, Xian 710069, Peoples R China.
C3 Xi'an Jiaotong University; Northwest University Xi'an
RP Yang, HX (corresponding author), Xi An Jiao Tong Univ, Dept Nutr & Food Safety, Sch Publ Hlth, Xian 710061, Peoples R China.
EM zhangrj@mail.xjtu.edu.cn; yuyan@xjtu.edu.cn; dengjianjun@nwu.edu.cn;
   zhangchao9277@163.com; yyyyyy_214@163.com; chengy@mail.xjtu.edu.cn;
   miniqiao@126.com; hanbei@mail.xjtu.edu.cn; yanghx@xjtu.edu.cn
RI Cheng, Yue/Z-4456-2019; HAN, Bei/JDX-1508-2023; Jianjun,
   Deng/U-5306-2019; Zhang, Ruijuan/JAX-6400-2023; Yang,
   Haixia/AAH-3819-2020
OI Zhang, Chao/0000-0001-5733-4368; Yang, Haixia/0000-0002-4410-9257; Yu,
   Yan/0000-0003-2751-6624; Han, Bei/0000-0002-7841-5543; Deng,
   Jianjun/0000-0002-3057-6997
FU National Natural Science Foundation of China [21306146, 21476184];
   Specialized Research Fund for the Doctoral Program of Higher Education
   [20130201120077]
FX This project was supported by the National Natural Science Foundation of
   China (21306146 and 21476184) and Specialized Research Fund for the
   Doctoral Program of Higher Education (20130201120077).
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NR 39
TC 41
Z9 44
U1 1
U2 16
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD MAY
PY 2016
VL 8
IS 5
AR 276
DI 10.3390/nu8050276
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA DP8XI
UT WOS:000378780900037
PM 27171111
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Parra, P
   Serra, F
   Palou, A
AF Parra, Pilar
   Serra, Francisca
   Palou, Andreu
TI Transcriptional analysis reveals a high impact of conjugated linoleic
   acid on stearoyl-Coenzyme A desaturase 1 mRNA expression in mice
   gastrocnemius muscle
SO GENES AND NUTRITION
LA English
DT Article
DE Conjugated linoleic acid; Scd1; Lipogenesis; Muscle; Obesity
ID ENDOPLASMIC-RETICULUM STRESS; INDUCED INSULIN-RESISTANCE;
   SKELETAL-MUSCLE; COA DESATURASE; FATTY-ACID; METABOLIC SYNDROME;
   ENDOTHELIAL-CELLS; BODY-COMPOSITION; GENE-EXPRESSION; BETA-CELLS
AB We examined the potential implication of skeletal muscle in the fat-lowering effect observed in mice treated with moderate doses of CLA. In experiment 1, mice fed with a standard-fat diet were orally treated with sunflower oil (control) and 3 or 10 mg CLA mixture/day for 37 days. In experiment 2, mice were fed with a high-fat diet for 65 days. For the first 30 days, they received the same doses as in experiment 1 and, from that time onwards, animals received double doses. Gene expression of key proteins involved in fatty acid transport, oxidation, regulation of lipid and carbohydrate utilization, composition of muscle fiber, and thermogenesis were determined and, in most of them, no major impact of CLA was seen. Therefore, enhancement of fatty acid oxidation in muscle did not seem to contribute to the antiobesity effect of CLA as seen in other studies with higher CLA doses. However, a strong induction of classically associated lipogenic genes such as Fasn (up to twofold) and, particularly, Scd1 (up to ninefold) was found. This activation could contribute to a protective role in muscle cells, since expression of ER stress markers was decreased and inversely correlated with the induction of Scd1.
C1 [Parra, Pilar; Serra, Francisca; Palou, Andreu] Univ Balear Islands, Lab Mol Biol Nutr & Biotechnol, Palma De Mallorca 07122, Spain.
   [Parra, Pilar; Serra, Francisca; Palou, Andreu] CIBER Fisiopatol Obesidad & Nutr CIBER OBN, Palma De Mallorca 07122, Spain.
C3 CIBER - Centro de Investigacion Biomedica en Red; CIBEROBN
RP Serra, F (corresponding author), Univ Balear Islands, Lab Mol Biol Nutr & Biotechnol, Cra Valldemossa Km 7-5, Palma De Mallorca 07122, Spain.
EM francisca.serra@uib.es
RI Parra, Pilar/IWD-8902-2023; Palou, Andreu/K-9881-2014; Serra,
   Francisca/B-8641-2008
OI Palou, Andreu/0000-0002-0295-4452; Serra, Francisca/0000-0002-8307-9732
FU Spanish Government [AGL2009-11277]; European project BIOCLAIMS
   [FP7-244995]
FX This work was supported by the grant AGL2009-11277 from the Spanish
   Government and the European project BIOCLAIMS (FP7-244995). CIBER-OBN de
   Fisiopatologia de la Obesidad y Nutricion is an initiative from ISCIII.
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NR 40
TC 10
Z9 10
U1 0
U2 6
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1555-8932
J9 GENES NUTR
JI Genes Nutr.
PD OCT
PY 2012
VL 7
IS 4
BP 537
EP 548
DI 10.1007/s12263-011-0279-x
PG 12
WC Genetics & Heredity; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Genetics & Heredity; Nutrition & Dietetics
GA 010EY
UT WOS:000309078700007
PM 22234647
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Rosenow, A
   Noben, JP
   Jocken, J
   Kallendrusch, S
   Fischer-Posovszky, P
   Mariman, ECM
   Renes, J
AF Rosenow, Anja
   Noben, Jean-Paul
   Jocken, Johan
   Kallendrusch, Sonja
   Fischer-Posovszky, Pamela
   Mariman, Edwin C. M.
   Renes, Johan
TI Resveratrol-Induced Changes of the Human Adipocyte Secretion Profile
SO JOURNAL OF PROTEOME RESEARCH
LA English
DT Article
DE human adipocytes; RSV; adipokines; lipolysis; 2-DE LC-MS/MS
ID EPITHELIUM-DERIVED FACTOR; ADIPOSE TRIGLYCERIDE LIPASE;
   PLASMINOGEN-ACTIVATOR INHIBITOR-1; INSULIN-RESISTANCE; METABOLIC
   SYNDROME; 3T3-L1 ADIPOCYTES; OXIDATIVE STRESS; LIFE-SPAN;
   SACCHAROMYCES-CEREVISIAE; EXTRACELLULAR-MATRIX
AB Enlarged white adipose tissue (WAT) is a feature of obesity and leads to changes in its paracrine and endocrine function. Dysfunction of WAT cells is associated with obesity-associated disorders like type 2 diabetes and cardiovascular diseases. Resveratrol (RSV), a natural polyphenolic compound, mimics beneficial effects of calorie restriction. As such, RSV seems a promising therapeutic target for obesity-associated disorders. The effect of RSV on the human adipokine profile is still elusive. Therefore, a proteomic study together with bioinformatical analysis was performed to investigate the effect of RSV on the secretion profile of mature human SGBS adipocytes. RSV incubation resulted in elevated basal glycerol release and reduced intracellular TG content. This increased intracellular lipolysis was accompanied by profound changes in the adipocyte secretion profile. Extracellular matrix proteins were down-regulated while processing proteins were mostly up-regulated after RSV treatment. Interestingly, RSV induced secretion of proteins protective against cellular stress and proteins involved in the regulation of apoptosis. Furthermore, we found a RSV-induced up-regulation of adiponectin and ApoE accompanied by a down-regulation of PAI-1 and PEDF secretion which may improve anti-inflammatory processes and increased insulin sensitivity. These effects may contribute to alleviate obesity-induced metabolic complications. In addition, two novel RSV-regulated adipocyte-secreted proteins were identified.
C1 [Rosenow, Anja; Jocken, Johan; Kallendrusch, Sonja; Mariman, Edwin C. M.; Renes, Johan] Maastricht Univ, Dept Human Biol, NUTRIM Sch Nutr Toxicol & Metab, NL-6200 MD Maastricht, Netherlands.
   [Noben, Jean-Paul] Hasselt Univ, Biomed Res Inst, Diepenbeek, Belgium.
   [Noben, Jean-Paul] Transnat Univ Limburg, Sch Life Sci, Diepenbeek, Belgium.
   [Fischer-Posovszky, Pamela] Univ Ulm, Med Ctr, Div Pediat Endocrinol & Diabet, Endocrine Res Lab, D-89069 Ulm, Germany.
C3 Maastricht University; Maastricht University Medical Centre (MUMC);
   Hasselt University; Hasselt University; Ulm University
RP Rosenow, A (corresponding author), Maastricht Univ, Dept Human Biol, NUTRIM Sch Nutr Toxicol & Metab, POB 616, NL-6200 MD Maastricht, Netherlands.
EM a.rosenow@maastrichtuniversity.nl
RI Kallendrusch, Sonja/AAV-7179-2020; Noben, Jean-Paul/E-8066-2011;
   Fischer-Posovszky, Pamela/D-5815-2016
OI Noben, Jean-Paul/0000-0003-3368-5686; Fischer-Posovszky,
   Pamela/0000-0003-3402-9840
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NR 79
TC 31
Z9 88
U1 0
U2 18
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1535-3893
EI 1535-3907
J9 J PROTEOME RES
JI J. Proteome Res.
PD SEP
PY 2012
VL 11
IS 9
BP 4733
EP 4743
DI 10.1021/pr300539b
PG 11
WC Biochemical Research Methods
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 000MH
UT WOS:000308389900031
PM 22905912
DA 2025-06-11
ER

PT J
AU Ruel, G
   Pomerleau, S
   Couture, P
   Lemieux, S
   Lamarche, B
   Couillard, C
AF Ruel, Guillaume
   Pomerleau, Sonia
   Couture, Patrick
   Lemieux, Simone
   Lamarche, Benoit
   Couillard, Charles
TI Low-calorie cranberry juice supplementation reduces plasma oxidized LDL
   and cell adhesion molecule concentrations in men
SO BRITISH JOURNAL OF NUTRITION
LA English
DT Article
DE cranberry; flavonoids; oxidized LDL; cardiovascular disease; ICAM-1;
   VCAM-1
ID GREEN TEA INGESTION; PURPLE GRAPE JUICE; KAPPA-B; OXIDATIVE STRESS; RED
   WINE; METABOLIC SYNDROME; ENDOTHELIAL-CELLS; MONOCYTE ADHESION; CULTURED
   HUMAN; ORANGE JUICE
AB Elevated circulating concentrations of oxidized LDL (OxLDL) and cell adhesion molecules are considered to be relevant markers of oxidative stress and endothelial activation which are implicated in the development of CVD. On the other hand, it has been suggested that dietary flavonoid consumption may be cardioprotective through possible favourable impacts on LDL particle oxidation and endothelial activation. The present study was undertaken to determine the effect of the daily consumption of low-calorie cranberry juice cocktail on plasma OxLDL, intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and E-selectin concentrations in men. Thirty men (mean age 51 (SD 10) years) were recruited and asked to consume increasing daily doses of cranberry juice cocktail (125, 250 and 500ml/d) over three successive periods of 4 weeks. Plasma OxLDL and adhesion molecule concentrations were measured by ELISA before and after each phase. We noted a significant decrease in plasma OxLDL concentrations following the intervention (P<0.0001). We also found that plasma ICAM-1 (P<0.0001) and VCAM-1 (P<0.05) concentrations decreased significantly during the course of the study. In summary, the present results show that daily cranberry juice cocktail consumption is associated with decreases in plasma OxLDL, ICAM-1 and VCAM-1 concentrations in men.
C1 [Ruel, Guillaume; Pomerleau, Sonia; Couture, Patrick; Lemieux, Simone; Lamarche, Benoit; Couillard, Charles] Univ Laval, Inst Nutraceut & Funct Foods, Dept Food Sci & Nutr, Quebec City, PQ G1K 7P4, Canada.
   [Couture, Patrick] CHUQ Res Ctr, Lipid Res Ctr, Quebec City, PQ G1V 4G2, Canada.
C3 Laval University; Laval University; Laval University Hospital
RP Couillard, C (corresponding author), Univ Laval, Inst Nutraceut & Funct Foods, Dept Food Sci & Nutr, 2440 Blvd Hochelaga, Quebec City, PQ G1K 7P4, Canada.
EM charles.couillard@inaf.ulaval.ca
RI Lamarche, Benoit/ABA-4785-2021
OI Couture, Patrick/0000-0002-8414-3847; Lamarche,
   Benoit/0000-0002-4443-5378; Lemieux, Simone/0000-0003-3170-4062;
   Couillard, Charles/0000-0002-6281-8663
CR [Anonymous], 2005, HEART DIS STROKE STA
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NR 53
TC 76
Z9 86
U1 0
U2 13
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1145
EI 1475-2662
J9 BRIT J NUTR
JI Br. J. Nutr.
PD FEB
PY 2008
VL 99
IS 2
BP 352
EP 359
DI 10.1017/S0007114507811986
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 260YF
UT WOS:000253045600020
PM 17761017
OA Bronze
DA 2025-06-11
ER

PT J
AU de Alwis, NMW
   Day, CP
AF de Alwis, Nimantha Mark Wilfred
   Day, Christopher Paul
TI Genetics of alcoholic liver disease and nonalcoholic fatty liver disease
SO SEMINARS IN LIVER DISEASE
LA English
DT Review
DE alcoholic liver disease; nonalcoholic liver disease; polymorphisms
ID MANGANESE SUPEROXIDE-DISMUTASE; PROLIFERATOR-ACTIVATED RECEPTOR;
   NECROSIS-FACTOR-ALPHA; TRANSFER PROTEIN GENE; INSULIN-RESISTANCE;
   PROMOTER POLYMORPHISM; HEPATOCELLULAR-CARCINOMA; OXIDATIVE STRESS;
   INCREASED RISK; STEATOHEPATITIS
AB Although the vast majority of heavy drinkers and individuals with obesity, insulin resistance, and the metabolic syndrome have steatosis, only a minority ever develop steatohepatitis, fibrosis, and cirrhosis. Genetic and environmental risk factors for advanced alcoholic liver disease (ALD) and nonalcoholic fatty liver disease (NAFLD) seem likely to include factors that influence the severity of steatosis and oxidative stress, the cytokine milieu, the magnitude of the immune response, and/or the severity of liver fibrosis. For ALD, the dose and pattern of alcohol intake, coffee intake, and dietary and other lifestyle factors leading to obesity are the most important environmental determinants of disease risk. For NAFLD, dietary saturated fat and antioxidant intake, small bowel bacterial overgrowth, and obstructive sleep apnea syndrome may play a role. Family studies and interethnic variations in susceptibility suggest that genetic factors are important in determining disease risk. For ALD, functional polymorphisms in the ADH and ALDH alcohol metabolizing genes play a role in determining susceptibility in Oriental populations. No genetic associations with advanced NAFLD have been replicated in large studies. Preliminary data suggest that polymorphisms in the genes encoding microsomal triglyceride transfer protein, superoxide dismutase 2, the CD14 endotoxin receptor, tumor necrosis factor alpha, transforming growth factor beta, and angiotensinogen may be associated with steatohepatitis or hepatic fibrosis or both.
C1 Med Sch Newcastle Upon Tyne, Sch Clin Med Sci, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England.
   Newcastle Univ, Inst Cellular Med, Liver Res Grp, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England.
C3 Newcastle University - UK; Newcastle University - UK
RP Day, CP (corresponding author), Med Sch Newcastle Upon Tyne, Sch Clin Med Sci, Floor 4 William Leech Bldg,Framlington Pl, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England.
RI Day, Christopher/Z-3305-2019
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NR 96
TC 147
Z9 160
U1 5
U2 145
PU THIEME MEDICAL PUBL INC
PI NEW YORK
PA 333 SEVENTH AVE, NEW YORK, NY 10001 USA
SN 0272-8087
EI 1098-8971
J9 SEMIN LIVER DIS
JI Semin. Liver Dis.
PD FEB
PY 2007
VL 27
IS 1
BP 44
EP 54
DI 10.1055/s-2006-960170
PG 11
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 153LX
UT WOS:000245438100005
PM 17295176
DA 2025-06-11
ER

PT J
AU Haney, A
   Buysse, DJ
   Rosario, BL
   Chen, YF
   Okun, ML
AF Haney, Alyssa
   Buysse, Daniel J.
   Rosario, Bedda L.
   Chen, Yi-Fan
   Okun, Michele L.
TI Sleep disturbance and cardiometabolic risk factors in early pregnancy: a
   preliminary study
SO SLEEP MEDICINE
LA English
DT Article
DE Pregnancy; Sleep disturbance; Blood pressure; BMI; Sleep latency;
   Weight; Actigraphy
ID BLOOD-PRESSURE; DURATION; OBESITY; ASSOCIATIONS; PREVALENCE; DISORDERS;
   INSOMNIA; STRESS; WOMEN
AB Background: Cardiometabolic (CM) risk factors are linked to increased morbidity. Disturbed sleep is associated with CM risk factors in late pregnancy, but little is known about sleep in early pregnancy and CM risk factors.
   Methods: Diary and actigraphy-assessed sleep information, as well as CM outcomes (blood pressure (BP) and body mass index (BMI)), were collected thrice from pregnant women (N = 161) in early pregnancy: T1 (10-12 weeks), T2 (14-16 weeks) and T3 (18-20 weeks). The sleep variables evaluated included sleep onset latency (SOL), wake after sleep onset (WASO) and total sleep time (TST). Sleep variables were dichotomised using established clinical cut-offs.
   Results: BMI and BP significantly changed across time. Women with persistent SOL >= 20 min had greater BMI than women without persistent SOLP20 min prior to covariate adjustment at T1 and T2, but at T3 the BMI values converged. Similar results were observed for persistent WASO >= 30 min. Persistently long WASO, as measured by actigraphy, was associated with elevated SBP, after controlling for covariates.
   Conclusions: Consistent with anecdotal evidence, it appears as if a subset of women report substantial difficulty initiating and maintaining sleep during early pregnancy and this may augment the risk of higher BP and BMI. Understanding these relationships is important as CM risk factors are linked to maternal and infant morbidity. Assessing sleep in early pregnancy may bestow time necessary for appropriate intervention. (C) 2014 Elsevier B. V. All rights reserved.
C1 [Haney, Alyssa; Buysse, Daniel J.; Okun, Michele L.] Univ Pittsburgh, Sch Med, Dept Psychiat, Pittsburgh, PA 15213 USA.
   [Rosario, Bedda L.; Chen, Yi-Fan] Univ Pittsburgh, Epidemiol Data Ctr, Grad Sch Publ Hlth, Pittsburgh, PA 15213 USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE); University
   of Pittsburgh; Pennsylvania Commonwealth System of Higher Education
   (PCSHE); University of Pittsburgh
RP Okun, ML (corresponding author), Univ Pittsburgh, Western Psychiat Inst & Clin, 3811 OHara St E1124, Pittsburgh, PA 15213 USA.
EM mlo34@pitt.edu
RI Buysse, Daniel/AAJ-1608-2021
FU NIH [NR010813]; CTSI [UL1 RR024153, UL1 TR000005]
FX Supported by NIH NR010813 and CTSI UL1 RR024153 and UL1 TR000005. The
   National Institutes of Health specifically disclaim responsibility for
   any analyses, interpretations or conclusions. M.L.O. has had full access
   to the data, and takes full responsibility for the integrity of the data
   and accuracy of the analysis.
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NR 34
TC 32
Z9 38
U1 0
U2 14
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1389-9457
EI 1878-5506
J9 SLEEP MED
JI Sleep Med.
PD APR
PY 2014
VL 15
IS 4
BP 444
EP 450
DI 10.1016/j.sleep.2014.01.003
PG 7
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA AE1WK
UT WOS:000333762500011
PM 24657205
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Vecera, R
   Poruba, M
   Hüttl, M
   Malinska, H
   Oliyarnyk, O
   Markova, I
   Racova, Z
   Soukop, J
   Kazdova, L
AF Vecera, Rostislav
   Poruba, Martin
   Huttl, Martina
   Malinska, Hana
   Oliyarnyk, Olena
   Markova, Irena
   Racova, Zuzana
   Soukop, Jan
   Kazdova, Ludmila
TI Beneficial Effect of Fenofibrate and Silymarin on Hepatic Steatosis and
   Gene Expression of Lipogenic and Cytochrome P450 Enzymes in Non-Obese
   Hereditary Hypertriglyceridemic Rats
SO CURRENT ISSUES IN MOLECULAR BIOLOGY
LA English
DT Article
DE NAFLD; fenofibrate; silymarin; triglycerides; liver; lipoperoxidation
ID PROLIFERATOR-ACTIVATED RECEPTOR; FATTY LIVER-DISEASE; PPAR-ALPHA;
   SILYBUM-MARIANUM; OXIDATIVE STRESS; LIPID-METABOLISM; ACID; DERIVATIVES;
   ROLES; NAFLD
AB The efficacy of fenofibrate in the treatment of hepatic steatosis has not been clearly demonstrated. In this study, we investigated the effects of fenofibrate and silymarin, administered as monotherapy and in combination to existing hepatic steatosis in a unique strain of hereditary hypertriglyceridemic rats (HHTg), a non-obese model of metabolic syndrome. HHTg rats were fed a standard diet without or with fenofibrate (100 mg/kg b.wt./day) or with silymarin (1%) or with a combination of fenofibrate with silymarin for four weeks. Fenofibrate alone and in combination with silymarin decreased serum and liver triglycerides and cholesterol and increased HDL cholesterol. These effects were associated with the decreased gene expression of enzymes involved in lipid synthesis and transport, while enzymes of lipid conversion were upregulated. The combination treatment had a beneficial effect on the gene expression of hepatic cytochrome P450 (CYP) enzymes. The expression of the CYP2E1 enzyme, which is source of hepatic reactive oxygen species, was reduced. In addition, fenofibrate-induced increased CYP4A1 expression was decreased, suggesting a reduction in the pro-inflammatory effects of fenofibrate. These results show high efficacy and mechanisms of action of the combination of fenofibrate with silymarin in treating hepatic steatosis and indicate the possibility of protection against disorders in which oxidative stress and inflammation are involved.
C1 [Vecera, Rostislav; Poruba, Martin; Racova, Zuzana; Soukop, Jan] Palacky Univ, Fac Med & Dent, Dept Pharmacol, Olomouc 77515, Czech Republic.
   [Huttl, Martina; Malinska, Hana; Oliyarnyk, Olena; Markova, Irena; Kazdova, Ludmila] Ctr Expt Med, Inst Clin & Expt Med, Prague 14021, Czech Republic.
C3 Palacky University Olomouc; Institute for Clinical & Experimental
   Medicine (IKEM)
RP Poruba, M (corresponding author), Palacky Univ, Fac Med & Dent, Dept Pharmacol, Olomouc 77515, Czech Republic.
EM vecera@seznam.cz; martin.poruba@upol.cz; martina.huttl@ikem.cz;
   hana.malinska@ikem.cz; ooliyarnyk@yahoo.com; irena.markova@ikem.cz;
   zuzu.matuskova@seznam.cz; jan.soukop01@upol.cz; lukazdova@seznam.cz
OI Kazdova, Ludmila/0000-0003-0563-0186; Poruba,
   Martin/0000-0003-1252-4971; Markova, Irena/0000-0002-4331-7636
FU Internal Grant Agency of Palacky University in Olomouc
   [IGA_LF_2022_006]; Czech Science Foundation; Ministry of Health of the
   Czech Republic under its program for the conceptual development of
   research organizations (Institute for Clinical and Experimental
   Medicine-IKEM) [IN 00023001]
FX This study was supported by grant IGA_LF_2022_006 of the Internal Grant
   Agency of Palacky University in Olomouc and a grant from the Czech
   Science Foundation and by the Ministry of Health of the Czech Republic
   under its program for the conceptual development of research
   organizations (Institute for Clinical and Experimental Medicine-IKEM, IN
   00023001).
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   Yu XH, 2015, ADV CLIN CHEM, V71, P171, DOI 10.1016/bs.acc.2015.06.005
   Zicha J, 2006, PHYSIOL RES, V55, pS49, DOI 10.33549/physiolres.930000.55.S1.49
NR 57
TC 0
Z9 1
U1 0
U2 8
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1467-3037
EI 1467-3045
J9 CURR ISSUES MOL BIOL
JI Curr. Issues Mol. Biol.
PD MAY
PY 2022
VL 44
IS 5
BP 1889
EP 1900
DI 10.3390/cimb44050129
PG 12
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 1P3NY
UT WOS:000801920900001
PM 35678658
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Chiu, HY
   Huang, WY
   Ho, CH
   Wang, JJ
   Lin, SJ
   Hsu, YW
   Chen, PJ
AF Chiu, Hsien-Yi
   Huang, Wen-Yen
   Ho, Chung-Han
   Wang, Jhi-Joung
   Lin, Sung-Jan
   Hsu, Ya-Wen
   Chen, Ping-Jen
TI Increased risk of chronic kidney disease in patients with rosacea: A
   nationwide population-based matched cohort study
SO PLOS ONE
LA English
DT Article
ID METABOLIC SYNDROME; CARDIOVASCULAR-DISEASE; OXIDATIVE STRESS;
   INFLAMMATION; MORTALITY; ASSOCIATION; ACTIVATION; PSORIASIS; SEVERITY;
   TAIWAN
AB Background
   Rosacea is a chronic inflammatory skin disorder. Inflammation and oxidative stress are involved in the etiopathogenesis of rosacea and chronic kidney disease (CKD). This study aimed to investigate the association between rosacea and CKD.
   Methods
   This population-based cohort study identified 277 patients with rosacea in the Taiwan National Health Insurance Research Database during 2001-2005. These patients were matched for age, sex, and comorbidities with 2216 patients without rosacea. All subjects were individually followed-up for 8-12 years to identify those who subsequently developed CKD
   Results
   The incidence rates of CKD per 1000 person-years were 16.02 in patients with rosacea and 10.63 in the non-rosacea reference population. After adjusting for other covariates and considering the competing risk of mortality, patients with rosacea remained at increased risk of CKD (adjusted sub-distribution hazard ratio (aSD-HR) 2.00; 95% confidence interval (CI) 1.05-3.82). The aSD-HRs (95% CI) for CKD were 1.82 (0.83-4.00) and 2.53 (1.11-5.75) for patients with mild and moderate-to-severe rosacea, respectively.
   Conclusions
   Rosacea is an independent risk factor for CKD. High rosacea severity and old age further increased CKD risk in patients with rosacea. Careful monitoring for CKD development should be included as part of integrated care for patients with rosacea.
C1 [Chiu, Hsien-Yi; Huang, Wen-Yen; Lin, Sung-Jan] Natl Taiwan Univ, Coll Med, Inst Biomed Engn, Taipei, Taiwan.
   [Chiu, Hsien-Yi; Huang, Wen-Yen; Lin, Sung-Jan] Natl Taiwan Univ, Coll Engn, Taipei, Taiwan.
   [Chiu, Hsien-Yi] Natl Taiwan Univ Hosp, Hsin Chu Branch, Dept Dermatol, Hsinchu, Taiwan.
   [Chiu, Hsien-Yi; Lin, Sung-Jan] Natl Taiwan Univ Hosp, Dept Dermatol, Taipei, Taiwan.
   [Chiu, Hsien-Yi; Lin, Sung-Jan] Natl Taiwan Univ, Coll Med, Taipei, Taiwan.
   [Ho, Chung-Han; Wang, Jhi-Joung; Hsu, Ya-Wen] Chi Mei Med Ctr, Dept Med Res, Tainan, Taiwan.
   [Ho, Chung-Han; Hsu, Ya-Wen] Chia Nan Univ Pharm & Sci, Dept Hosp & Hlth Care Adm, Tainan, Taiwan.
   [Ho, Chung-Han] Chia Nan Univ Pharm & Sci, Dept Pharm, Tainan, Taiwan.
   [Lin, Sung-Jan] Natl Taiwan Univ, Res Ctr Dev Biol & Regenerat Med, Taipei, Taiwan.
   [Chen, Ping-Jen] Chi Mei Med Ctr, Dept Geriatr & Gerontol, Tainan, Taiwan.
   [Chen, Ping-Jen] Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Family Med, Kaohsiung, Taiwan.
C3 National Taiwan University; National Taiwan University; National Taiwan
   University; National Taiwan University Hospital; National Taiwan
   University; National Taiwan University Hospital; National Taiwan
   University; Chi Mei Hospital; Chia Nan University of Pharmacy & Science;
   Chia Nan University of Pharmacy & Science; National Taiwan University;
   Chi Mei Hospital; Kaohsiung Medical University; Kaohsiung Medical
   University Hospital
RP Chen, PJ (corresponding author), Chi Mei Med Ctr, Dept Geriatr & Gerontol, Tainan, Taiwan.; Chen, PJ (corresponding author), Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Family Med, Kaohsiung, Taiwan.
EM pingjen.chen@gmail.com
RI Chen, Ping-Jen/AAG-8548-2021
OI Chen, Ping-Jen/0000-0001-7636-0801; Chiu, Hsien-Yi/0000-0002-0493-9707;
   Huang, Wen-Yen Adam/0000-0001-9625-0802; Ho,
   Chung-Han/0000-0001-5925-8477
FU National Taiwan University Hospital Hsin-Chu Branch [106-HCH002]
FX This work was supported in part by a grant from the National Taiwan
   University Hospital Hsin-Chu Branch (106-HCH002). The funder had no role
   in study design, data collection and analysis, decision to publish, or
   preparation of the manuscript. There was no additional external funding
   received for this study.
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NR 39
TC 6
Z9 6
U1 0
U2 7
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD OCT 2
PY 2017
VL 12
IS 10
AR e0180446
DI 10.1371/journal.pone.0180446
PG 12
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA FI5MY
UT WOS:000412029600003
PM 28968402
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Sánchez-Armengol, A
   Villalobos-López, P
   Caballero-Eraso, C
   Carmona-Bernal, C
   Asensio-Cruz, M
   Barbé, F
   Capote, F
AF Sanchez-Armengol, A.
   Villalobos-Lopez, P.
   Caballero-Eraso, C.
   Carmona-Bernal, C.
   Asensio-Cruz, M.
   Barbe, F.
   Capote, F.
TI Gamma glutamyl transferase and oxidative stress in obstructive sleep
   apnea: a study in 1744 patients
SO SLEEP AND BREATHING
LA English
DT Article
DE Cardiovascular risk factor; Chronic oxidative stress; Obstructive sleep
   apnea; Population study
ID POSITIVE AIRWAY PRESSURE; YOUNG-ADULTS CARDIA; CARDIOVASCULAR-DISEASE;
   METABOLIC SYNDROME; RISK DEVELOPMENT; MORTALITY; ASSOCIATION; PREDICTOR;
   HYPOPNEA; OBESITY
AB We analyze a large population of patients to determine whether gamma glutamyl transferase (GGT) levels are increased in sleep apnea-hypopnea syndrome (OSA) and whether these levels are related to clinical characteristics or polygraphic indexes.
   A cross-sectional study in a population of 1744 patients referred for OSA suspicion was conducted. The following variables were determined: glucose, cholesterol, triglycerides, aspartate aminotransferase (GOT), alanine aminotransferase (GPT), GGT, body mass index, waist-hip ratio (WHR), and overnight sleep study.
   The 483 patients with GGT a parts per thousand yen40 IU/l were younger and more obese, and had a pattern of more centrally distributed fat than the 1261 with GGT < 40 IU/l. Patients with high levels of GGT also consumed more alcohol, had a poorer biochemical profile, and had more respiratory and oximetric alterations during sleep. GGT levels were significantly correlated with AHI, DI, and CT90. In the binary regression test, WHR, glucose, cholesterol, triglycerides, and grams of alcohol consumed per day predicted GGT levels a parts per thousand yen40 IU/l, while none of the polygraphic variables had predictive value.
   High GGT levels were associated with the severity of OSA. However, this relationship seems to be due to the coexistence of other associated factors, mainly central obesity, rather than to the respiratory disorders found in this disease.
C1 [Sanchez-Armengol, A.; Caballero-Eraso, C.; Carmona-Bernal, C.; Asensio-Cruz, M.; Capote, F.] Virgen Rocio Univ Hosp, Med Surg Unit Resp Dis, Seville, Spain.
   [Villalobos-Lopez, P.] Torrecardenas Hosp, Almeria, Spain.
   [Sanchez-Armengol, A.; Caballero-Eraso, C.; Carmona-Bernal, C.; Capote, F.] Biomed Res Inst, Seville, Spain.
   [Barbe, F.] Arnau Vilanova Hosp, Resp Dept, Lleida, Spain.
   [Barbe, F.] CIBERes, Lleida, Spain.
C3 Virgen del Rocio University Hospital; Hospital Torrecardenas; Consejo
   Superior de Investigaciones Cientificas (CSIC); University of Sevilla;
   CSIC-JA-USE - Instituto de Biomedicina de Sevilla (IBIS); University
   Hospital Arnau de Vilanova; CIBER - Centro de Investigacion Biomedica en
   Red; CIBERES
RP Caballero-Eraso, C (corresponding author), Calle Aguilas 16 Casa1, Seville 41003, Spain.
EM ccaballero-ibis@us.es
RI Asensio, Maria/F-1431-2015; Eraso, Candelaria/J-1059-2018; Barbe,
   Ferran/A-5988-2010
OI Asensio-Cruz, Maria Isabel/0000-0002-7377-9065; Caballero-Eraso,
   Candela/0000-0002-6428-0027; Barbe, Ferran/0000-0002-2340-8928
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NR 25
TC 7
Z9 7
U1 0
U2 11
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1520-9512
EI 1522-1709
J9 SLEEP BREATH
JI Sleep Breath.
PD SEP
PY 2015
VL 19
IS 3
BP 883
EP 890
DI 10.1007/s11325-014-1115-5
PG 8
WC Clinical Neurology; Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Respiratory System
GA CQ7DL
UT WOS:000360763000019
PM 25619707
DA 2025-06-11
ER

PT J
AU Jiao, J
   Dou, L
   Li, M
   Lu, YG
   Guo, HB
   Man, Y
   Wang, S
   Li, J
AF Jiao, Juan
   Dou, Lin
   Li, Miao
   Lu, Yonggang
   Guo, Han-Bang
   Man, Yong
   Wang, Shu
   Li, Jian
TI NADPH oxidase 2 plays a critical role in dysfunction and apoptosis of
   pancreatic β-cells induced by very low-density lipoprotein
SO MOLECULAR AND CELLULAR BIOCHEMISTRY
LA English
DT Article
DE VLDL; NIT-1 cells; Reactive oxygen species; NADPH oxidase 2; Apoptosis
ID TRANSCRIPTION FACTOR PDX-1; ENZYME GENE-EXPRESSION; METABOLIC-SYNDROME;
   OXIDATIVE STRESS; FACTOR FOXO1; DYSLIPIDEMIA; TRANSLOCATION;
   MITOCHONDRIAL; ISLETS; DAMAGE
AB In type 2 diabetes, pancreatic beta-cells cannot secret enough insulin compensate for insulin resistance, which are often accompanied by abnormality in lipid metabolism such as hypertriglyceridemia. It is reported that oxidative stress is involved in pancreatic beta-cell dysfunction. However, molecular mechanisms linking between excessive generations of reactive oxygen species (ROS) and beta-cell dysfunction and apoptosis induced by high levels of very low-density lipoprotein (VLDL) are poorly understood. In this study, we test the hypothesis that NADPH oxidase 2 (NOX2)-derived ROS may play a key role in dysfunction and apoptosis of pancreatic beta-cell induced by VLDL. Our results show that the ApoCIII transgenic mice displayed increased serum TG levels, enhanced generation of ROS and impaired insulin content in pancreatic beta-cells. In vitro, the treatment of pancreatic NIT-1 cells with 1 mg/ml VLDL for 12 h stimulated NOX2-derived ROS generation, decreased expression and secretion of insulin. Furthermore, we found that VLDL induced dysfunction and apoptosis of pancreatic beta-cells through JNK and p53 pathways, which were rescued by siRNA-mediated NOX2 reduction. In conclusion, our data demonstrate a critical role of NOX2-derived ROS in dysfunction and apoptosis through JNK and p53 pathways in pancreatic beta-cells induced by VLDL.
C1 [Jiao, Juan; Dou, Lin; Li, Miao; Lu, Yonggang; Guo, Han-Bang; Man, Yong; Wang, Shu; Li, Jian] Beijing Hosp, Key Lab Geriatr, Beijing 100730, Peoples R China.
   [Jiao, Juan; Dou, Lin; Li, Miao; Lu, Yonggang; Guo, Han-Bang; Man, Yong; Wang, Shu; Li, Jian] Minist Hlth, Beijing Inst Geriatr, Beijing 100730, Peoples R China.
   [Jiao, Juan; Dou, Lin; Lu, Yonggang; Li, Jian] Peking Union Med Coll, Grad Sch, Beijing 100730, Peoples R China.
   [Jiao, Juan; Dou, Lin; Lu, Yonggang; Li, Jian] Chinese Acad Med Sci, Beijing 100730, Peoples R China.
C3 Beijing Hospital; Chinese Academy of Medical Sciences - Peking Union
   Medical College; Peking Union Medical College; Chinese Academy of
   Medical Sciences - Peking Union Medical College
RP Wang, S (corresponding author), Beijing Hosp, Key Lab Geriatr, Beijing 100730, Peoples R China.
EM ws3704@yahoo.com.cn; lijian@bjhmoh.cn
RI DOU, LIN/GRF-5703-2022
FU National Basic Research Program of China [2012CB517502]; National
   Natural Science Foundation of China [81070634]
FX We would like to thank Prof. Yi Zhu (Peking University Health Science
   Center) for providing NIT-1 cells. Prof. Guoqing Liu (Peking University
   Health Science Center) for providing ApoCIII transgenic mice. This work
   was supported by grants from National Basic Research Program of China
   (2012CB517502) and National Natural Science Foundation of China
   (81070634).
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NR 32
TC 13
Z9 14
U1 0
U2 10
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0300-8177
J9 MOL CELL BIOCHEM
JI Mol. Cell. Biochem.
PD NOV
PY 2012
VL 370
IS 1-2
BP 103
EP 113
DI 10.1007/s11010-012-1402-z
PG 11
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA 015XB
UT WOS:000309478600012
PM 22911512
DA 2025-06-11
ER

PT J
AU Schattenberg, JM
   Schuppan, D
AF Schattenberg, Joern M.
   Schuppan, Detlef
TI Nonalcoholic steatohepatitis: the therapeutic challenge of a global
   epidemic
SO CURRENT OPINION IN LIPIDOLOGY
LA English
DT Review
DE fibrogenesis; fibrosis; inflammation; insulin resistance; lipotoxicity;
   liver; nonalcoholic fatty liver; nonalcoholic steatohepatitis; oxidative
   stress; treatment
ID FATTY LIVER-DISEASE; PLACEBO-CONTROLLED TRIAL; RANDOMIZED
   CONTROLLED-TRIAL; VITAMIN-E; WEIGHT-LOSS; PHYSICAL-ACTIVITY;
   HEPATIC-FIBROSIS; HISTOLOGICAL SEVERITY; CYP2E1 OVEREXPRESSION; RECEPTOR
   ANTAGONIST
AB Purpose of review
   Nonalcoholic fatty liver (NAFL) and especially its inflammatory variant nonalcoholic steatohepatitis (NASH) have become a major challenge to healthcare systems worldwide because of the increasing prevalence of its major risk factors obesity and type 2 diabetes, which are closely linked to overeating, physical inactivity, and the metabolic syndrome.
   Recent findings
   Between 10 and 20% of patients with NAFL develop (NASH), which can progress to cirrhosis, end-stage liver disease, and hepatocellular carcinoma. The overall mortality in these patients is significantly increased because of both cardiovascular and liver-related complications. Sustained weight loss by diet and exercise, which is the most effective therapeutic measure, is only achieved by a minority of patients, having led to a great yet unmet need for medical therapies of NASH.
   Summary
   Pharmacological therapies should target the underlying pathophysiology that involves insulin resistance, enhanced peripheral lipolysis and release of free fatty acids, oxidative stress, accumulation of toxic lipids, adipose tissue inflammation, sensitization of hepatocytes toward apoptotic cell death, and fibrogenesis. However, pharmacological therapy that is well tolerated, cost-effective, and poses an acceptable risk-to-benefit ratio has still to be identified. This review summarizes the current and promising treatment options and their implications for future research and clinical practice.
C1 [Schattenberg, Joern M.; Schuppan, Detlef] Johannes Gutenberg Univ Mainz, Univ Med Ctr, Dept Med 1, D-55116 Mainz, Germany.
   [Schuppan, Detlef] Johannes Gutenberg Univ Mainz, Univ Med Ctr, Ctr Mol & Translat Med, D-55116 Mainz, Germany.
   [Schuppan, Detlef] Beth Israel Deaconess Med Ctr, Div Gastroenterol, Boston, MA 02215 USA.
   [Schuppan, Detlef] Harvard Univ, Sch Med, Boston, MA USA.
C3 Johannes Gutenberg University of Mainz; Johannes Gutenberg University of
   Mainz; Harvard University; Harvard University Medical Affiliates; Beth
   Israel Deaconess Medical Center; Harvard University; Harvard Medical
   School
RP Schuppan, D (corresponding author), Johannes Gutenberg Univ Mainz, Univ Med Ctr, Dept Med 1, Langenbeckstr 1, D-55116 Mainz, Germany.
EM detlef.schuppan@unimedizin-mainz.de
OI Schattenberg, Jorn M./0000-0002-4224-4703
FU Deutsche Forschungsgemeinschaft (DFG); NIH
FX J.M.S. receives funding from the Deutsche Forschungsgemeinschaft (DFG)
   and D.S. has received funding from the NIH.
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NR 99
TC 96
Z9 105
U1 0
U2 24
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0957-9672
EI 1473-6535
J9 CURR OPIN LIPIDOL
JI Curr. Opin. Lipidology
PD DEC
PY 2011
VL 22
IS 6
BP 479
EP 488
DI 10.1097/MOL.0b013e32834c7cfc
PG 10
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism; Peripheral
   Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism;
   Cardiovascular System & Cardiology
GA 853DR
UT WOS:000297406900006
PM 22002020
DA 2025-06-11
ER

PT J
AU Kruit, JK
   Brunham, LR
   Verchere, CB
   Hayden, MR
AF Kruit, Janine K.
   Brunham, Liam R.
   Verchere, C. Bruce
   Hayden, Michael R.
TI HDL and LDL cholesterol significantly influence β-cell function in type
   2 diabetes mellitus
SO CURRENT OPINION IN LIPIDOLOGY
LA English
DT Review
DE beta-cells; ABCA1; HDL; type 2 diabetes mellitus
ID HIGH-DENSITY-LIPOPROTEIN; APOLIPOPROTEIN-A-I; CORONARY-ARTERY-DISEASE;
   ABCA1-DEFICIENT MACROPHAGES; GLUCOSE-HOMEOSTASIS; INSULIN-SECRETION;
   DYSFUNCTION; RECEPTORS; PARTICLES; PLASMA
AB Purpose of review
   Patients with type 2 diabetes mellitus (T2DM) display significant abnormalities in both LDL and HDL particles. Recent data suggest that these changes in lipoprotein particles could contribute to the pathogenesis of T2DM. In this review, we focus on these abnormalities and discuss their possible impact on beta-cell function and beta-cell mass.
   Recent findings
   Infusion of reconstituted HDL in T2DM patients improves beta-cell function, whereas carriers of loss-of-function mutations in the cholesterol transporter ABCA1, who have decreased HDL levels, have impaired beta-cell function. In addition, recent studies show that HDL protects against stress-induced beta-cell apoptosis in vitro. Finally, increasing evidence points to a role for islet inflammation in the pathogenesis of T2DM. ABCA1 and ABCG1 may also modulate these inflammatory responses, suggesting an additional pathway by which HDL may impact T2DM.
   Summary
   Recent findings indicate that HDL protects beta-cells from cholesterol-induced beta-cell dysfunction, stress-induced apoptosis and islet inflammation. As the protective properties of HDL are compromised in patients with metabolic syndrome and T2DM, dysfunctional HDL metabolism could contribute to the pathogenesis of T2DM. Therapeutic normalization of both the quantity and quality of HDL particles may be a novel approach to prevent or treat T2DM.
C1 [Kruit, Janine K.; Brunham, Liam R.; Hayden, Michael R.] Univ British Columbia, Ctr Mol Med & Therapeut, Dept Med Genet, Vancouver, BC V5Z 4H4, Canada.
   [Verchere, C. Bruce] Univ British Columbia, Child & Family Res Inst, Dept Surg, Vancouver, BC V5Z 4H4, Canada.
   [Verchere, C. Bruce] Univ British Columbia, Child & Family Res Inst, Dept Pathol & Lab Med, Vancouver, BC V5Z 4H4, Canada.
C3 University of British Columbia; Child & Family Research Institute;
   University of British Columbia; University of British Columbia; Child &
   Family Research Institute
RP Hayden, MR (corresponding author), Univ British Columbia, Ctr Mol Med & Therapeut, Dept Med Genet, 950 W 28th Ave,Room 3026, Vancouver, BC V5Z 4H4, Canada.
EM mrh@cmmt.ubc.ca
RI Kruit, Janine/AGI-8582-2022; Hayden, Michael/D-8581-2011
OI Hayden, Michael/0000-0001-5159-1419; Verchere, Cameron
   Bruce/0000-0002-9262-0586; Kruit, Janine/0000-0002-5414-0485
FU Canadian Institutes of Health Research (CIHR); Michael Smith Foundation
   for Health Research (MSFHR)
FX J.K. K. is supported by postdoctoral fellowship awards from the Canadian
   Institutes of Health Research (CIHR) and the Michael Smith Foundation
   for Health Research (MSFHR). C. B. V. is a MSFHR Senior Scholar. M. R.
   H. holds a Canada Research Chair in Human Genetics and is a University
   of British Columbia Killam Professor. This work was supported by CIHR
   grants to M. R. H. and C. B. V.
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NR 65
TC 119
Z9 124
U1 1
U2 23
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0957-9672
EI 1473-6535
J9 CURR OPIN LIPIDOL
JI Curr. Opin. Lipidology
PD JUN
PY 2010
VL 21
IS 3
BP 178
EP 185
DI 10.1097/MOL.0b013e328339387b
PG 8
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism; Peripheral
   Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism;
   Cardiovascular System & Cardiology
GA 601ZG
UT WOS:000278106300003
PM 20463468
DA 2025-06-11
ER

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   Pinarbas, Esra
   Mercantepe, Tolga
TI Effect of White Tea on Leptin and Asprosin Levels in Rats Feeding a
   High-Fat Diet
SO LIFE-BASEL
LA English
DT Article
DE asprosin; antioxidant; high-fat diet; leptin; obesity; white tea
ID GREEN TEA; OXIDATIVE STRESS; METABOLIC-DISORDERS; ADIPOSE-TISSUE;
   OBESITY; THEANINE
AB Background: Currently, obesity affects over 600 million individuals and is responsible for numerous severe health conditions, particularly diabetes and metabolic syndrome. The objective of our study was to examine the impact of white tea, known for its potent antioxidant properties, on the reduction in body weight as well as the levels of leptin and asprosin. Methods: A total of 72 male Sprague-Dawley rats were randomly assigned to 9 groups, with each group consisting of 8 rats. The groups were partitioned into two in order to examine the preventative and therapeutic effects of white tea on obesity. During this study, the case groups were administered white tea together with a high-fat diet, whereas the positive control group was administered orlistat along with a high-fat diet through oral gavage. After the experiment concluded, the levels of leptin, asprosin, and insulin hormones were evaluated in serum samples collected from rats using the ELISA method. Results: The findings demonstrated that the administration of white tea led to a significant decrease in body weight, serum leptin, and asprosin levels, as well as oxidative stress indicators, in rats that were fed a high-fat diet. Conclusions: Utilizing natural chemicals, such as white tea, which possess minimal side effects and have powerful antioxidant activity, can mitigate the detrimental consequences associated with obesity.
C1 [Yilmaz, Adnan; Toraman, Merve Nur; Karakas, Sibel Mataraci; Pinarbas, Esra] Recep Tayyip Erdogan Univ, Fac Med, Dept Biochem, TR-53020 Rize, Turkiye.
   [Ozden, Zulkar; Mercantepe, Tolga] Recep Tayyip Erdogan Univ, Fac Med, Dept Histol & Embryol, TR-53020 Rize, Turkiye.
C3 Recep Tayyip Erdogan University; Recep Tayyip Erdogan University
RP Yilmaz, A (corresponding author), Recep Tayyip Erdogan Univ, Fac Med, Dept Biochem, TR-53020 Rize, Turkiye.
EM adnan.yilmaz@erdogan.edu.tr; m.nurtoraman@gmail.com;
   sibel.karakas@erdogan.edu.tr; zulkar.ozden@saglik.gov.tr;
   esra.pinarbas@erdogan.edu.tr; tolga.mercantepe@erdogan.edu.tr
RI Mercantepe, Tolga/O-1073-2013; Mataraci Karakas, Sibel/GXF-9961-2022;
   yilmaz, adnan/ABB-9340-2020
OI Mataraci Karakas, Sibel/0000-0001-7147-5087; mercantepe,
   tolga/0000-0002-8506-1755; yilmaz, adnan/0000-0003-4842-1173
FU Recep Tayyip Erdogan University Scientific Research Projects
   Coordination Unit; Recep Tayyip Erdogan University Development
   Foundation [02024010013116];  [TYL-2020-1175]
FX The study was supported by Recep Tayyip Erdogan University Scientific
   Research Projects Coordination Unit with the code number TYL-2020-1175.
   In addiaiton, this study has been supported by the Recep Tayyip Erdogan
   University Development Foundation (Grant number: 02024010013116).
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NR 75
TC 0
Z9 0
U1 11
U2 11
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2075-1729
J9 LIFE-BASEL
JI Life-Basel
PD DEC
PY 2024
VL 14
IS 12
AR 1548
DI 10.3390/life14121548
PG 22
WC Biology; Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics; Microbiology
GA Q7Z9X
UT WOS:001386823300001
PM 39768256
OA gold
DA 2025-06-11
ER

PT J
AU Li, XH
   He, YJ
   Wang, DW
   Momeni, MR
AF Li, Xiaohong
   He, Yanjin
   Wang, Dawu
   Momeni, Mohammad Reza
TI Chronobiological disruptions: unravelling the interplay of shift work,
   circadian rhythms, and vascular health in the context of stroke risk
SO CLINICAL AND EXPERIMENTAL MEDICINE
LA English
DT Review
DE Shift work; Stroke risk; Circadian rhythms; Hypertension; Diabetes
   mellitus
ID CEREBRAL-BLOOD-FLOW; CARDIOVASCULAR-DISEASE; ISCHEMIC-STROKE;
   ARTERIAL-HYPERTENSION; MOLECULAR-MECHANISMS; METABOLIC SYNDROME;
   DIABETES-MELLITUS; OXIDATIVE STRESS; NIGHT WORKERS; LIFE YEARS
AB Shift work, particularly night shifts, disrupts circadian rhythms and increases stroke risk. This manuscript explores the mechanisms connecting shift work with stroke, focusing on circadian rhythms, hypertension, and diabetes. The circadian system, controlled by different mechanisms including central and peripheral clock genes, suprachiasmatic nuclei (SCN), and pineal gland (through melatonin production), regulates body functions and responds to environmental signals. Disruptions in this system affect endothelial cells, leading to blood pressure issues. Type 2 diabetes mellitus (T2DM) is significantly associated with night shifts, with circadian disturbances affecting glucose metabolism, insulin sensitivity, and hormone regulation. The manuscript examines the relationship between melatonin, insulin, and glucose balance, highlighting pathways that link T2DM to stroke risk. Additionally, dyslipidemia, particularly reduced HDL-c levels, results from shift work and contributes to stroke development. High lipid levels cause oxidative stress, inflammation, and endothelial dysfunction, increasing cerebrovascular risks. The manuscript details the effects of dyslipidemia on brain functions, including disruptions in blood flow, blood-brain barrier integrity, and neural cell death. This comprehensive analysis emphasizes the complex interplay of circadian disruption, hypertension, diabetes, and dyslipidemia in increasing stroke risk among shift workers. Understanding these mechanisms is essential for developing targeted interventions to reduce stroke susceptibility and improve cerebrovascular health in this vulnerable population.
C1 [Li, Xiaohong; He, Yanjin; Wang, Dawu] Chongqing Med Univ, Affiliated Hosp 1, Dept Rehabil Med, Chongqing 400016, Peoples R China.
   [Momeni, Mohammad Reza] Univ Tehran Med Sci, Sch Med, Tehran, Iran.
C3 Chongqing Medical University; Tehran University of Medical Sciences
RP He, YJ (corresponding author), Chongqing Med Univ, Affiliated Hosp 1, Dept Rehabil Med, Chongqing 400016, Peoples R China.; Momeni, MR (corresponding author), Univ Tehran Med Sci, Sch Med, Tehran, Iran.
EM 18580210692@163.com; Momeni.m1209@gmail.com
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NR 150
TC 11
Z9 11
U1 15
U2 28
PU SPRINGER-VERLAG ITALIA SRL
PI MILAN
PA VIA DECEMBRIO, 28, MILAN, 20137, ITALY
SN 1591-8890
EI 1591-9528
J9 CLIN EXP MED
JI Clin. Exper. Med.
PD NOV 14
PY 2024
VL 25
IS 1
AR 6
DI 10.1007/s10238-024-01514-w
PG 14
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA M0T8Y
UT WOS:001354766400001
PM 38833370
OA Green Accepted, hybrid
HC N
HP Y
DA 2025-06-11
ER

PT J
AU Michailidis, M
   Moraitou, D
   Tata, DA
   Kalinderi, K
   Papamitsou, T
   Papaliagkas, V
AF Michailidis, Michalis
   Moraitou, Despina
   Tata, Despina A.
   Kalinderi, Kallirhoe
   Papamitsou, Theodora
   Papaliagkas, Vasileios
TI Alzheimer's Disease as Type 3 Diabetes: Common Pathophysiological
   Mechanisms between Alzheimer's Disease and Type 2 Diabetes
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE amyloid beta; Alzheimer type 3 diabetes; inflammation and cognition;
   brain insulin resistance; type 2 diabetes mellitus
ID INSULIN-DEGRADING ENZYME; ISLET AMYLOID POLYPEPTIDE; GLYCATION
   END-PRODUCTS; CEREBRAL GLUCOSE-METABOLISM; GROWTH-FACTOR EXPRESSION;
   BRAIN IN-VIVO; OXIDATIVE STRESS; A-BETA; APOLIPOPROTEIN-E;
   NEURODEGENERATION ROLES
AB Globally, the incidence of type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD) epidemics is increasing rapidly and has huge financial and emotional costs. The purpose of the current review article is to discuss the shared pathophysiological connections between AD and T2DM. Research findings are presented to underline the vital role that insulin plays in the brain's neurotransmitters, homeostasis of energy, as well as memory capacity. The findings of this review indicate the existence of a mechanistic interplay between AD pathogenesis with T2DM and, especially, disrupted insulin signaling. AD and T2DM are interlinked with insulin resistance, neuroinflammation, oxidative stress, advanced glycosylation end products (AGEs), mitochondrial dysfunction and metabolic syndrome. Beta-amyloid, tau protein and amylin can accumulate in T2DM and AD brains. Given that the T2DM patients are not routinely evaluated in terms of their cognitive status, they are rarely treated for cognitive impairment. Similarly, AD patients are not routinely evaluated for high levels of insulin or for T2DM. Studies suggesting AD as a metabolic disease caused by insulin resistance in the brain also offer strong support for the hypothesis that AD is a type 3 diabetes.
C1 [Michailidis, Michalis; Moraitou, Despina; Tata, Despina A.] Aristotle Univ Thessaloniki, Sch Psychol, Lab Psychol, Thessaloniki 54124, Greece.
   [Kalinderi, Kallirhoe] Aristotle Univ Thessaloniki, Lab Med Biol Genet, Sch Med, Fac Hlth Sci, Thessaloniki 54124, Greece.
   [Papamitsou, Theodora] Aristotle Univ Thessaloniki, Fac Med, Histol & Embryol Dept, Thessaloniki 54124, Greece.
   [Papaliagkas, Vasileios] Int Hellen Univ, Sch Hlth Sci, Dept Biomed Sci, Thessaloniki 57400, Greece.
C3 Aristotle University of Thessaloniki; Aristotle University of
   Thessaloniki; Aristotle University of Thessaloniki; International
   Hellenic University
RP Papaliagkas, V (corresponding author), Int Hellen Univ, Sch Hlth Sci, Dept Biomed Sci, Thessaloniki 57400, Greece.
EM elfmike@hotmail.com; despinamorait@gmail.com; dtata@psy.auth.gr;
   roey111@hotmail.com; thpapami@auth.gr; vpapal@auth.gr
RI Papaliagkas, Vasileios/HKV-7303-2023; Tata, Despina/AAH-5300-2020;
   Papamitsou, Theodora/ABA-9855-2020; Moraitou, Despina/I-7379-2012
OI Moraitou, Despina/0000-0002-0527-7143; Papaliagkas,
   Vasileios/0000-0003-1064-0290; Tata, Despina/0000-0001-5563-4017
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NR 147
TC 143
Z9 149
U1 13
U2 83
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD MAR
PY 2022
VL 23
IS 5
AR 2687
DI 10.3390/ijms23052687
PG 14
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA ZR7ZT
UT WOS:000767998600001
PM 35269827
OA gold, Green Published
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Wang, HJ
   Wang, Q
   Lv, ZM
   Wang, CL
   Li, CP
   Rong, YL
AF Wang, H. -J.
   Wang, Q.
   Lv, Z. -M.
   Wang, C. -L.
   Li, C. -P.
   Rong, Y. -L.
TI Resveratrol appears to protect against oxidative stress and
   steroidogenesis collapse in mice fed high-calorie and high-cholesterol
   diet
SO ANDROLOGIA
LA English
DT Article
DE Leydig cell; obesity; oxidative stress; resveratrol; steroidogenesis
ID METABOLIC SYNDROME; INSULIN-RESISTANCE; MALE-INFERTILITY; SEMEN QUALITY;
   PROFILE; HYPERCHOLESTEROLEMIA; HYPOGONADISM; EXPRESSION; PARAMETERS;
   LEYDIG
AB The detrimental effects on Leydig cells steroidogenesis in mice on high-calorie and high-cholesterol diet (HCD) were determined, and the possible protection conferred by resveratrol supplementation was investigated. Male C57BL/6J mice were fed high-calorie and alone (HCD group) or with resveratrol supplementation (HCD+Res group) for 18weeks. Male C57BL/6J mice fed standard diet without or with the same dose of resveratrol served as controls. At the end of the experiment, there were significant declines of serum testosterone and luteinising hormone (LH) in HCD group as compared to controls. In line with the hormone alterations, the expressions of StAR and steroidogenic enzymes in testicular tissues were significantly down-regulated in HCD group. Resveratrol supplementation could significantly improve expressions of StAR and steroidogenic enzymes, and increase serum testosterone and LH concentrations in HCD+Res group. Mice in HCD group also showed a statistically significant down-regulation in the mRNA expressions of MnSOD and GPx4. Resveratrol supplementation improved testicular MnSOD and GPx4 expression in comparison with HCD group. We propose that resveratrol may attenuate detrimental effects on Leydig cells steroidogenesis in HCD-fed mice, and its upregulations of antioxidant defence mechanisms and LH level may play a role in its protection. Our data suggest resveratrol appears to have the potential for therapeutic approaches targeting male obesity-associated secondary hypogonadism.
C1 [Wang, H. -J.; Wang, Q.; Lv, Z. -M.] Anhui Med Univ, Dept Histol & Embryol, Hefei 230032, Peoples R China.
   [Wang, C. -L.; Li, C. -P.; Rong, Y. -L.] Anhui Med Univ, Hefei, Peoples R China.
C3 Anhui Medical University; Anhui Medical University
RP Lv, ZM (corresponding author), Anhui Med Univ, Dept Histol & Embryol, Hefei 230032, Peoples R China.
EM lvzm99@126.com
FU Natural Science Foundation of Anhui Province Education Department, China
   [KJ2013A148]; Grants for Scientific Research of BSKY from Anhui Medical
   University [XJ201010]; National Students Innovation Training
   [201310366005]
FX This study was supported by the Natural Science Foundation of Anhui
   Province Education Department, China (Grant number: KJ2013A148), Grants
   for Scientific Research of BSKY (Grant number: XJ201010) from Anhui
   Medical University, and National Students Innovation Training for 2013
   year (Grant number: 201310366005). The authors are grateful to Kai Zhang
   and Prof. Xiangguo Liu in Department of Histology, Embryology and
   Biology, Anhui University of Traditional Chinese Medicine, for kindly
   help in establishing experimental animal models and valuable
   suggestions.
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NR 28
TC 27
Z9 29
U1 0
U2 14
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0303-4569
EI 1439-0272
J9 ANDROLOGIA
JI Andrologia
PD FEB
PY 2015
VL 47
IS 1
BP 59
EP 65
DI 10.1111/and.12231
PG 7
WC Andrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA AZ2JN
UT WOS:000348060100012
PM 24456142
OA gold
DA 2025-06-11
ER

PT J
AU Davis, JE
   Gabler, NK
   Walker-Daniels, J
   Spurlock, ME
AF Davis, J. E.
   Gabler, N. K.
   Walker-Daniels, J.
   Spurlock, M. E.
TI The c-Jun N-Terminal Kinase Mediates the Induction of Oxidative Stress
   and Insulin Resistance by Palmitate and Toll-like Receptor 2 and 4
   Ligands in 3T3-L1 Adipocytes
SO HORMONE AND METABOLIC RESEARCH
LA English
DT Article
DE adipose tissue; obesity; cytokines; chemokines
ID NECROSIS-FACTOR-ALPHA; FACTOR-KAPPA-B; FREE FATTY-ACIDS; SKELETAL-MUSCLE
   CELLS; ADIPOSE-TISSUE; TNF-ALPHA; INFLAMMATORY CHANGES; DEPENDENT
   PATHWAYS; METABOLIC SYNDROME; EXPRESSION
AB Saturated fatty acids (SFAs) are known to induce inflammation and insulin resistance in adipocytes through toll-like receptor-4 (Tlr4) signaling, but the mechanisms are not well delineated. Furthermore, the potential roles of Tlr2 and the c-Jun N-terminal kinase (JNK) in inflammation in adipocytes have not been investigated. We demonstrated that palmitate, lipopolysaccharide (LPS), and the toll-like receptor-2 (Tlr2) agonist, zymosan A (ZymA), induced insulin resistance in a time- and dose-dependent manner in 3T3-L1 adipocytes. Corresponding with the reduction of insulin sensitivity was an increased expression of IL-6, as well as activation of the proinflammatory transcription factors, nuclear factor kappa B, and activator protein-1. Reactive oxygen species (ROS) accumulation was also observed in palmitate and Tlr agonist treated adipocytes. The JNK inhibitor, SP600125, attenuated insulin resistance mediated by SFA and Tlr agonists, which corresponded with a diminished proinflammatory response and reduced ROS accumulation. Collectively, these results demonstrated Tlr2 involvement in adipocyte inflammation and therefore implicated the receptor as a potential target for SFA. Moreover, activation of JNK also appeared to be essential to Tlr2-, as well as Tlr4-induced insulin resistance and oxidative stress.
C1 [Spurlock, M. E.] Iowa State Univ, Dept Food Sci & Human Nutr, Ames, IA 50011 USA.
   [Davis, J. E.] So Illinois Univ, Carbondale, IL 62901 USA.
C3 Iowa State University; Southern Illinois University System; Southern
   Illinois University
RP Spurlock, ME (corresponding author), Iowa State Univ, Dept Food Sci & Human Nutr, Ames, IA 50011 USA.
EM mspurloc@iastate.edu
FU Nutrition and Wellness Research Center at Iowa State University
FX This work was supported by a grant from the Nutrition and Wellness
   Research Center at Iowa State University.
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NR 46
TC 73
Z9 86
U1 0
U2 13
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0018-5043
EI 1439-4286
J9 HORM METAB RES
JI Horm. Metab. Res.
PD JUL
PY 2009
VL 41
IS 7
BP 523
EP 530
DI 10.1055/s-0029-1202852
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 479DP
UT WOS:000268640200003
PM 19277946
DA 2025-06-11
ER

PT J
AU Puzhankara, L
   Janakiram, C
AF Puzhankara, Lakshmi
   Janakiram, Chandrashekar
TI Common Risk Factor Approach to Limit Noncommunicable Diseases and
   Periodontal Disease-The Molecular and Cellular Basis: A Narrative Review
SO JOURNAL OF INTERNATIONAL SOCIETY OF PREVENTIVE AND COMMUNITY DENTISTRY
LA English
DT Review
DE Common risk factor approach; noncommunicable diseases; oral health;
   periodontal disease; risk factors
ID LOW-GRADE INFLAMMATION; PORPHYROMONAS-GINGIVALIS; INSULIN-RESISTANCE;
   METABOLIC SYNDROME; DIABETES-MELLITUS; CIGARETTE-SMOKING; TUMOR
   PROGRESSION; CANCER-RISKS; OBESITY; STRESS
AB Introduction: The link between periodontal disease and noncommunicable diseases (NCDs) has been the subject of major research over the past several years. The primary objective of this review is to understand the cellular and molecular components that link common risk factors (exposure) in adult patients (population) with periodontal disease and other NCDs (outcome). The secondary objective is to interpret from existing literature the possibility of identifying the molecular plausibility of the Common Risk Factor Approach (CRFA). Materials and Methods: A literature search was performed in PubMed/MEDLINE, CINAHL, Web of Science, and Google Scholar for all published articles pertaining to the molecular and cellular basis of the risk factors between periodontal diseases and major NCDs. Data from all randomized and nonrandomized clinical trials, cross-sectional studies, case-control, cohort studies, literature, and systematic reviews were included. Results: Periodontal pathogens, stress, obesity, smoking, and dietary factors are some of the common risk factors between periodontal disease and NCDs. Conclusion: Understanding the molecular and cellular link of common risk factors between NCDs and periodontal disease would ensure the application of CRFA. The CRFA implies that controlling the risk factors associated with NCDs can have an incredible positive impact on regulating many chronic conditions, which would extend to periodontal health also.
C1 [Puzhankara, Lakshmi] Manipal Acad Higher Educ, Manipal Coll Dent Sci, Dept Periodontol, Manipal, Karnataka, India.
   [Janakiram, Chandrashekar] Amrita Vishwa Vidyapeetham, Amrita Sch Dent, Dept Publ Hlth Dent, Kochi, Kerala, India.
C3 Manipal Academy of Higher Education (MAHE); Amrita Vishwa Vidyapeetham;
   Amrita Vishwa Vidyapeetham Kochi
RP Puzhankara, L (corresponding author), Manipal Acad Higher Educ, Manipal Coll Dent Sci, Dept Periodontol, Manipal, Karnataka, India.
EM lakshmi.puzhankara@manipal.edu
RI Janakiram, Chandrashekar/M-7953-2015
OI Janakiram, Chandrashekar/0000-0003-1907-8708
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NR 75
TC 6
Z9 6
U1 2
U2 4
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, Maharashtra, INDIA
SN 2231-0762
EI 2250-1002
J9 J INT SOC PREV COMMU
JI J. Int. Soc. Prev. Community Dent.
PD SEP-OCT
PY 2021
VL 11
IS 5
BP 490
EP 502
DI 10.4103/jispcd.JISPCD_109_21
PG 13
WC Dentistry, Oral Surgery & Medicine
WE Emerging Sources Citation Index (ESCI)
SC Dentistry, Oral Surgery & Medicine
GA UZ6VM
UT WOS:000702341200003
PM 34760792
OA Green Published
DA 2025-06-11
ER

PT J
AU Bizzarri, M
   Fuso, A
   Dinicola, S
   Cucina, A
   Bevilacqua, A
AF Bizzarri, Mariano
   Fuso, Andrea
   Dinicola, Simona
   Cucina, Alessandra
   Bevilacqua, Arturo
TI Pharmacodynamics and pharmacokinetics of inositol(s) in health and
   disease
SO EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY
LA English
DT Review
DE Myo-inositol; inositol phosphates; cell signalling; phosphoinositides;
   inositolphosphoglycans
ID D-CHIRO-INOSITOL; SPERM MITOCHONDRIAL-FUNCTION;
   POLYCYSTIC-OVARY-SYNDROME; IN-VITRO MATURATION; MYO-INOSITOL;
   MYOINOSITOL SUPPLEMENTATION; ALZHEIMERS-DISEASE; PHOSPHATIDYLINOSITOL
   5-PHOSPHATE; PHOSPHOLIPID-COMPOSITION; CEREBROSPINAL-FLUID
AB Introduction: Inositol and its derivatives comprise a huge field of biology. Myo-inositol is not only a prominent component of membrane-incorporated phosphatidylinositol, but participates in its free form, with its isomers or its phosphate derivatives, to a multitude of cellular processes, including ion channel permeability, metabolic homeostasis, mRNA export and translation, cytoskeleton remodeling, stress response.
   Areas covered: Bioavailability, safety, uptake and metabolism of inositol is discussed emphasizing the complexity of interconnected pathways leading to phosphoinositides, inositol phosphates and more complex molecules, like glycosyl-phosphatidylinositols.
   Expert opinion: Besides being a structural element, myo-inositol exerts unexpected functions, mostly unknown. However, several reports indicate that inositol plays a key role during phenotypic transitions and developmental phases. Furthermore, dysfunctions in the regulation of inositol metabolism have been implicated in several chronic diseases. Clinical trials using inositol in pharmacological doses provide amazing results in the management of gynecological diseases, respiratory stress syndrome, Alzheimer's disease, metabolic syndrome, and cancer, for which conventional treatments are disappointing. However, despite the widespread studies carried out to identify inositol-based effects, no comprehensive understanding of inositol-based mechanisms has been achieved. An integrated metabolomics-genomic study to identify the cellular fate of therapeutically administered myo-inositol and its genomic/enzymatic targets is urgently warranted.
C1 [Bizzarri, Mariano] Sapienza Univ Rome, Dept Expt Med, Rome, Italy.
   [Bizzarri, Mariano; Fuso, Andrea] Sapienza Univ Rome, Syst Biol Grp Lab, Rome, Italy.
   [Fuso, Andrea] IRCCS Santa Lucia Fdn, European Ctr Brain Res CERC, Rome, Italy.
   [Dinicola, Simona] Sapienza Univ Rome, Dept Clin & Mol Med, Rome, Italy.
   [Dinicola, Simona; Cucina, Alessandra] Sapienza Univ Rome, Dept Surg Pietro Valdoni, Rome, Italy.
   [Cucina, Alessandra] Azienda Policlin Umberto I, Rome, Italy.
   [Bevilacqua, Arturo] Sapienza Univ Rome, Sect Neurosci, Dept Psychol, Rome, Italy.
C3 Sapienza University Rome; Sapienza University Rome; IRCCS Santa Lucia;
   Sapienza University Rome; Sapienza University Rome; Sapienza University
   Rome; University Hospital Sapienza Rome; Sapienza University Rome
RP Bizzarri, M (corresponding author), Sapienza Univ Rome, Syst Biol Grp Lab, Dept Expt Med, Via A Scarpa 14, I-00161 Rome, Italy.
EM mariano.bizzarri@uniroma1.it
RI Fuso, Andrea/G-7390-2012; Bevilacqua, Arturo/HTS-2499-2023; Bizzarri,
   Mariano/U-8300-2017
OI Fuso, Andrea/0000-0001-9467-5671
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NR 173
TC 129
Z9 137
U1 2
U2 27
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1742-5255
EI 1744-7607
J9 EXPERT OPIN DRUG MET
JI Expert Opin. Drug Metab. Toxicol.
PY 2016
VL 12
IS 10
BP 1181
EP 1196
DI 10.1080/17425255.2016.1206887
PG 16
WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology
GA DX4BO
UT WOS:000384323800006
PM 27351907
DA 2025-06-11
ER

PT J
AU do Carmo, RF
   Vasconcelos, LRS
   Mendonça, TF
   Cavalcanti, MDD
   Pereira, LMMB
   Moura, P
AF do Carmo, Rodrigo Feliciano
   Silva Vasconcelos, Luydson Richardson
   Mendonca, Taciana Furtado
   de Mendonca Cavalcanti, Maria do Socorro
   Moreira Beltrao Pereira, Leila Maria
   Moura, Patricia
TI Myeloperoxidase gene polymorphism predicts fibrosis severity in women
   with hepatitis C
SO HUMAN IMMUNOLOGY
LA English
DT Article
DE Fibrosis; HCV; MPO; Polymorphism; SOD
ID MANGANESE SUPEROXIDE-DISMUTASE; ALCOHOLIC LIVER-DISEASE;
   HEPATOCELLULAR-CARCINOMA; OXIDATIVE-STRESS; VIRUS-INFECTION;
   ALZHEIMERS-DISEASE; HCV INFECTION; RISK; SUSCEPTIBILITY; DIMORPHISM
AB Oxidative stress plays an important role on liver fibrosis progression in the course of hepatitis C virus (HCV) infection. Myeloperoxidase (MPO) is an enzyme released by neutrophils and macrophages, responsible for generating hypochlorous acid and reactive oxygen species (ROS) that may lead to liver injury in HCV infection. On the other hand, antioxidant enzymes such as manganese superoxide dismutase (SOD) controls ROS-mediated damage. The aim of the present study was to investigate the influence of MPO G-463A and SOD2 Alal6Val polymorphisms in the severity of liver fibrosis in individuals with chronic HCV infection. The present study included 270 patients with chronic HCV recruited from the Gastrohepatology Service of the Oswaldo Cruz University Hospital/Liver Institute of Pernambuco (Recife, Northeastern Brazil). All patients underwent liver biopsy, which was classified according METAVIR score. The SNPs were determined by real-time PCR. After multivariate analysis adjustment, the GG genotype of MPO and the presence of metabolic syndrome were independently associated with fibrosis severity in women (P = 0.025 OR 2.25 CI 1.10-4.59 and P = 0.032 OR 2.32 CI 1.07-5.01, respectively). The presence of the GG genotype seems to be a risk factor for fibrosis severity in women with HCV. (C) 2014 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.
C1 [do Carmo, Rodrigo Feliciano] Univ Fed Vale Sao Francisco, Colegiado Ciencias Farmaceut, Petrolina, PE, Brazil.
   [do Carmo, Rodrigo Feliciano; Mendonca, Taciana Furtado] Rede Nordeste Biotecnol, Recife, PE, Brazil.
   [Silva Vasconcelos, Luydson Richardson; Moreira Beltrao Pereira, Leila Maria] Inst Figado Pernambuco, Recife, PE, Brazil.
   [de Mendonca Cavalcanti, Maria do Socorro; Moura, Patricia] Univ Pernambuco, Inst Ciencias Biol, Recife, PE, Brazil.
   [Moreira Beltrao Pereira, Leila Maria] Univ Pernambuco, Fac Ciencias Med, Recife, PE, Brazil.
C3 Universidade Federal do Vale do Sao Francisco; Universidade de
   Pernambuco (UPE); Universidade de Pernambuco (UPE)
RP do Carmo, RF (corresponding author), Fundacao Univ Fed Vale Sao Francisco, Colegiado Ciencias Farmaceut, Av Jose de Sa Manicoba S-N, BR-56304917 Petrolina, PE, Brazil.
EM rodrigo.carmo@univasf.edu.br
RI Vasconcelos, Luydson/AAC-4907-2020; Moura, Patricia/H-7233-2018;
   Feliciano do Carmo, Rodrigo/V-9795-2017; Vasconcelos,
   Luydson/C-9365-2014
OI Feliciano do Carmo, Rodrigo/0000-0001-9601-6995; Moura,
   Patricia/0000-0003-4259-388X; Vasconcelos, Luydson/0000-0002-1625-3358
FU FACEPE (Fundacao de Amparo a Ciencia e Tecnologia do Estado de
   Pernambuco) [APQ-0789-2010, APQ-1104-2.08]
FX This study was supported by grants from FACEPE (Fundacao de Amparo a
   Ciencia e Tecnologia do Estado de Pernambuco) APQ-0789-2010,
   APQ-1104-2.08.
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NR 41
TC 6
Z9 9
U1 0
U2 3
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0198-8859
EI 1879-1166
J9 HUM IMMUNOL
JI Hum. Immunol.
PD AUG
PY 2014
VL 75
IS 8
BP 766
EP 770
DI 10.1016/j.humimm.2014.05.008
PG 5
WC Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology
GA AM7CN
UT WOS:000340022400009
PM 24882572
DA 2025-06-11
ER

PT J
AU Lastra-Lastra, G
   Sowers, JR
   Restrepo-Erazo, K
   Manrique-Acevedo, C
   Lastra-González, G
AF Lastra-Lastra, Guido
   Sowers, James R.
   Restrepo-Erazo, Katherine
   Manrique-Acevedo, Camila
   Lastra-Gonzalez, Guido
TI Role of aldosterone and angiotensin II in insulin resistance: an update
SO CLINICAL ENDOCRINOLOGY
LA English
DT Review
ID TYPE-2 DIABETES-MELLITUS; SKELETAL-MUSCLE; RECEPTOR SUBSTRATE-1;
   ENDOTHELIAL FUNCTION; GLUCOSE-TRANSPORT; DOWN-REGULATION; NADPH OXIDASE;
   SPIRONOLACTONE; SENSITIVITY; SODIUM
AB P>The role of the Renin-Angiotensin-Aldosterone system (RAAS) on the development of insulin resistance and cardiovascular disease is an area of growing interest. Most of the deleterious actions of the RAAS on insulin sensitivity appear to be mediated through activation of the Angiotensin II (Ang II) Receptor type 1 (AT(1)R) and increased production of mineralocorticoids. The underlying mechanisms leading to impaired insulin sensitivity remain to be fully elucidated, but involve increased production of reactive oxygen species and oxidative stress. Both experimental and clinical studies also implicate aldosterone in the development of insulin resistance, hypertension, endothelial dysfunction, cardiovascular tissue fibrosis, remodelling, inflammation and oxidative stress. There is abundant evidence linking aldosterone, through non-genomic actions, to defective intracellular insulin signalling, impaired glucose homeostasis and systemic insulin resistance not only in skeletal muscle and liver but also in cardiovascular tissue. Blockade of the different components of the RAAS, in particular Ang II and AT(1)R, results in attenuation of insulin resistance, glucose homeostasis, as well as decreased cardiovascular disease morbidity and mortality. These beneficial effects go beyond to those expected with isolated control of hypertension. This review focuses on the role of Ang II and aldosterone in the pathogenesis of insulin resistance, as well as in clinical relevance of RAAS blockade in the prevention and treatment of the metabolic syndrome and cardiovascular disease.
C1 [Lastra-Lastra, Guido; Restrepo-Erazo, Katherine] Univ Nacl Colombia, Sch Med, Dept Internal Med, Div Endocrinol & Metab, Bogota, Colombia.
   [Sowers, James R.; Manrique-Acevedo, Camila; Lastra-Gonzalez, Guido] Univ Missouri, Dept Internal Med, Div Endocrinol & Diabet, Columbia, MO 65212 USA.
C3 Universidad Nacional de Colombia; University of Missouri System;
   University of Missouri Columbia
RP Lastra-González, G (corresponding author), D109 HSC Diabet Ctr,1 Hosp Dr, Columbia, MO 65212 USA.
EM lastrag@health.missouri.edu
OI Restrepo Erazo, Katherine/0009-0002-6066-2180
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NR 48
TC 91
Z9 104
U1 0
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0300-0664
EI 1365-2265
J9 CLIN ENDOCRINOL
JI Clin. Endocrinol.
PD JUL
PY 2009
VL 71
IS 1
BP 1
EP 6
DI 10.1111/j.1365-2265.2008.03498.x
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 457IQ
UT WOS:000266922100001
PM 19138313
DA 2025-06-11
ER

PT J
AU Lin, HC
   Tsai, SY
   Lee, HC
AF Lin, Herng-Ching
   Tsai, Shang-Ying
   Lee, Hsin-Chien
TI No higher risk of myocardial infarction among bipolar patients in a
   6-year follow-up of acute mood episodes
SO PSYCHOSOMATIC MEDICINE
LA English
DT Article
DE acute myocardial infarction; cardiovascular disease; bipolar disorder;
   acute mood episode; population-based study
ID CORONARY-ARTERY-DISEASE; CARDIOVASCULAR-DISEASE; MEDICAL COMORBIDITY;
   METABOLIC SYNDROME; DISORDER; MORTALITY; DEPRESSION; SCHIZOPHRENIA;
   ASSOCIATIONS; INDIVIDUALS
AB Objective: The aim of this study is to estimate the risk of acute myocardial infarction (AMI) among bipolar disorder patients during a 6-year follow-up after acute mood episodes. The risk is compared with that of a cohort of patients who underwent appendectomy operations during the same period. Methods: We used administrative claims data from the Taiwan National Health Insurance Research Database covering the years 1997-2002, with the two study cohorts comprising patients hospitalized for bipolar disorder (n = 1429) or appendectomies (n = 4993) in 1997. Multiple logistic regression analyses were performed to compare the crude odds ratio of patients in these cohorts developing AMI following the index discharge by gender. Results: A total of 2.24% of the bipolar disorder patients developed AMI during the 6-year follow-up period, when compared with 1.72% of the appendectomy patients. The multiple logistic regression analyses revealed that there were no significant relationships between the patients in the two cohorts developing AMI, regardless of gender. Conclusions: There were no significant differences in the risk of developing AMI between patients with bipolar disorder and patients undergoing appendectomy operations, when compared either by gender or as whole groups.
C1 [Lin, Herng-Ching] Taipei Med Univ, Sch Hlth Care Adm, Taipei, Taiwan.
   [Tsai, Shang-Ying; Lee, Hsin-Chien] Taipei Med Univ Hosp, Dept Psychiat, Taipei 110, Taiwan.
   [Tsai, Shang-Ying; Lee, Hsin-Chien] Taipei Med Univ, Dept Psychiat, Sch Med, Taipei, Taiwan.
C3 Taipei Medical University; Taipei Medical University; Taipei Medical
   University Hospital; Taipei Medical University
RP Lee, HC (corresponding author), Taipei Med Univ Hosp, Dept Psychiat, 252 Wu Hsing St, Taipei 110, Taiwan.
EM ellalee@tmu.edu.tw
RI LIN, HUI-CHEN/AAA-8973-2021; Lin, Chun-Jen/AAY-5582-2021
OI lee, hsin-chien/0000-0002-7557-8259; TSAI, SHANGYING/0000-0001-5662-0055
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NR 24
TC 24
Z9 25
U1 0
U2 8
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0033-3174
EI 1534-7796
J9 PSYCHOSOM MED
JI Psychosom. Med.
PD JAN
PY 2008
VL 70
IS 1
BP 73
EP 76
DI 10.1097/PSY.0b013e31815c1e93
PG 4
WC Psychiatry; Psychology; Psychology, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry; Psychology
GA 253GM
UT WOS:000252506700011
PM 18158377
DA 2025-06-11
ER

PT J
AU Ragusa, A
   Matta, M
   Cristiano, L
   Matassa, R
   Battaglione, E
   Svelato, A
   De Luca, C
   D'Avino, S
   Gulotta, A
   Rongioletti, MCA
   Catalano, P
   Santacroce, C
   Notarstefano, V
   Carnevali, O
   Giorgini, E
   Vizza, E
   Familiari, G
   Nottola, SA
AF Ragusa, Antonio
   Matta, Maria
   Cristiano, Loredana
   Matassa, Roberto
   Battaglione, Ezio
   Svelato, Alessandro
   De Luca, Caterina
   D'Avino, Sara
   Gulotta, Alessandra
   Rongioletti, Mauro Ciro Antonio
   Catalano, Piera
   Santacroce, Criselda
   Notarstefano, Valentina
   Carnevali, Oliana
   Giorgini, Elisabetta
   Vizza, Enrico
   Familiari, Giuseppe
   Nottola, Stefania Annarita
TI Deeply in Plasticenta: Presence of Microplastics in the Intracellular
   Compartment of Human Placentas
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Article
DE microplastics; human placenta; electron microscopy; cell organelles
ID POLYSTYRENE NANOPARTICLES; ULTRASTRUCTURE; MITOCHONDRIAL; PARTICLES;
   BIVALVES; STRESS; HEALTH; CELLS
AB Microplastics (MPs) are defined as plastic particles smaller than 5 mm. They have been found almost everywhere they have been searched for and recent discoveries have also demonstrated their presence in human placenta, blood, meconium, and breastmilk, but their location and toxicity to humans have not been reported to date. The aim of this study was twofold: 1. To locate MPs within the intra/extracellular compartment in human placenta. 2. To understand whether their presence and location are associated with possible structural changes of cell organelles. Using variable pressure scanning electron microscopy and transmission electron microscopy, MPs have been localized in ten human placentas. In this study, we demonstrated for the first time the presence and localization in the cellular compartment of fragments compatible with MPs in the human placenta and we hypothesized a possible correlation between their presence and important ultrastructural alterations of some intracytoplasmic organelles (mitochondria and endoplasmic reticulum). These alterations have never been reported in normal healthy term pregnancies until today. They could be the result of a prolonged attempt to remove and destroy the plastic particles inside the placental tissue. The presence of virtually indestructible particles in term human placenta could contribute to the activation of pathological traits, such as oxidative stress, apoptosis, and inflammation, characteristic of metabolic disorders underlying obesity, diabetes, and metabolic syndrome and partially accounting for the recent epidemic of non-communicable diseases.
C1 [Ragusa, Antonio] Univ Campus Bio Med Roma, Dept Obstet & Gynecol, Via Alvaro del Portillo 21, I-00128 Rome, Italy.
   [Matta, Maria] Univ Pavia, Fac Med & Surg, Dept Clinicosurg Diagnost & Pediat Sci, Via Alessandro Brambilla 74, I-27100 Pavia, Italy.
   [Cristiano, Loredana] Univ Aquila, Dept Life Hlth & Environm Sci, Via Vetoio, I-67010 Coppito, Italy.
   [Matassa, Roberto; Battaglione, Ezio; Familiari, Giuseppe; Nottola, Stefania Annarita] Sapienza Univ, Dept Anat Histol Forens Med & Orthopaed, Via A Borelli 50, I-00161 Rome, Italy.
   [Svelato, Alessandro; De Luca, Caterina; D'Avino, Sara; Gulotta, Alessandra] Fatebenefratelli Hosp, Dept Gynecol & Obstet San Giovanni Calibita, Via Ponte Quattro Capi 39, I-00186 Rome, Italy.
   [Rongioletti, Mauro Ciro Antonio; Catalano, Piera; Santacroce, Criselda] Fatebenefratelli Hosp, Dept Pathol Anat San Giovanni Calibita, Via Ponte Quattro Capi 39, I-00186 Rome, Italy.
   [Notarstefano, Valentina; Carnevali, Oliana; Giorgini, Elisabetta] Univ Politecn Marche, Dept Life & Environm Sci, Polo Montedago Via Brecce Bianche, I-60131 Ancona, Italy.
   [Vizza, Enrico] IRCCS Regina Elena Natl Canc Inst, Dept Expt Clin Oncol, Gynecol Oncol Unit, Via Elio Chianesi 53, I-00144 Rome, Italy.
C3 University Campus Bio-Medico - Rome Italy; University of Pavia;
   University of L'Aquila; Sapienza University Rome; Marche Polytechnic
   University
RP Cristiano, L (corresponding author), Univ Aquila, Dept Life Hlth & Environm Sci, Via Vetoio, I-67010 Coppito, Italy.
EM loredana.cristiano@univaq.it
RI Giorgini, Elisabetta/AAU-3596-2021; Matassa, Roberto/H-2988-2012;
   Notarstefano, Valentina/T-4158-2019; Svelato, Alessandro/K-5659-2018;
   Carnevali, Oliana/P-2751-2015
OI Familiari, Giuseppe/0000-0002-3456-1434; De Luca,
   Caterina/0000-0002-0623-1729; GIORGINI, ELISABETTA/0000-0003-0503-5870;
   Matassa, Roberto/0000-0002-6336-4587; Cristiano,
   Loredana/0000-0002-0539-0736; Svelato, Alessandro/0000-0003-4713-9539;
   Notarstefano, Valentina/0000-0002-4651-6235; Carnevali,
   Oliana/0000-0001-5994-0572; Ragusa, Antonio/0000-0002-2579-1027
FU Gruppo GEO (Gestione Emergenze Ostetriche); Italian Ministry of
   University and Research (Sapienza University, Rome-Project SEED-PNR
   2021)
FX This research was funded by Grants from Gruppo GEO (Gestione Emergenze
   Ostetriche) and from the Italian Ministry of University and Research
   (grants from Sapienza University, Rome-Project SEED-PNR 2021).
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NR 79
TC 79
Z9 85
U1 12
U2 87
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD SEP
PY 2022
VL 19
IS 18
AR 11593
DI 10.3390/ijerph191811593
PG 22
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA 4Q8XF
UT WOS:000856358900001
PM 36141864
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Urso, CJ
   Zhou, HP
AF Urso, C. J.
   Zhou, Heping
TI Palmitic Acid Lipotoxicity in Microglia Cells Is Ameliorated by
   Unsaturated Fatty Acids
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE fatty acid uptake; lipid droplets; lipoprotection; lipotoxicity; neutral
   lipid accumulation; palmitic acid; unsaturated fatty acids
ID ENDOPLASMIC-RETICULUM STRESS; SKELETAL-MUSCLE CELLS; LIPID DROPLETS;
   APOPTOSIS; ACTIVATION; FFAR1/GPR40; RESISTANCE; RECEPTORS; PROTECTS;
   EXPOSURE
AB Obesity and metabolic syndrome are associated with cognitive decline and dementia. Palmitic acid (PA) is increased in the cerebrospinal fluid of obese patients with cognitive impairment. This study was therefore designed to examine fatty acid (FA) lipotoxicity in BV2 microglia cells. We found that PA induced time- and dose-dependent decrease in cell viability and increase in cell death without affecting the cell cycle profile and that PA lipotoxicity did not depend on cell surface free fatty acid receptors but rather on FA uptake. Treatment with sulfosuccinimidyl oleate (SSO), an irreversible inhibitor of fatty acid translocase CD36, significantly inhibited FA uptake in BSA- and PA-treated cells and blocked PA-induced decrease in cell viability. Inhibition of ER stress or treatment with N-acetylcysteine was not able to rescue PA lipotoxicity. Our study also showed that unsaturated fatty acids (UFAs), such as linoleic acid (LA), oleic acid (OA), alpha-linolenic acid (ALA), and docosahexaenoic acid (DHA), were not lipotoxic but instead protected microglia against PA-induced decrease in cell viability. Co-treatment of PA with LA, OA, and DHA significantly inhibited FA uptake in PA-treated cells. All UFAs tested induced the incorporation of FAs into and the amount of neutral lipids, while PA did not significantly affect the amount of neutral lipids compared with BSA control.
C1 [Urso, C. J.; Zhou, Heping] Seton Hall Univ, Dept Biol Sci, S Orange, NJ 07079 USA.
C3 Seton Hall University
RP Zhou, HP (corresponding author), Seton Hall Univ, Dept Biol Sci, S Orange, NJ 07079 USA.
EM cj.urso@student.shu.edu; Heping.Zhou@shu.edu
OI Urso, C.J./0000-0003-3545-4769
FU Department of Biological Sciences at Seton Hall University
FX This study was supported by the research fund from the Department of
   Biological Sciences at Seton Hall University.
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NR 77
TC 34
Z9 36
U1 3
U2 27
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD AUG
PY 2021
VL 22
IS 16
AR 9093
DI 10.3390/ijms22169093
PG 18
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA UI2LY
UT WOS:000690446700001
PM 34445796
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Foster, MT
   Gentile, CL
   Cox-York, K
   Wei, YR
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AF Foster, Michelle T.
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   Cox-York, Kimberly
   Wei, Yuren
   Wang, Dong
   Estrada, Andrea L.
   Reese, Lauren
   Miller, Tirrel
   Pagliassotti, Michael J.
   Weir, Tiffany L.
TI Fuzhuan tea consumption imparts hepatoprotective effects and alters
   intestinal microbiota in high saturated fat diet-fed rats
SO MOLECULAR NUTRITION & FOOD RESEARCH
LA English
DT Article
DE Fuzhuan tea; Inflammation; Lactobacillus; Nonalcoholic fatty liver
   disease; Saturated fat
ID ENDOPLASMIC-RETICULUM STRESS; FERMENTED CAMELLIA-SINENSIS;
   LIVER-DISEASE; GREEN TEA; NONALCOHOLIC STEATOHEPATITIS; METABOLIC
   SYNDROME; BRICK-TEA; LACTOBACILLUS; LIPOPROTEINS; INFLAMMATION
AB Scope: Nonalcoholic fatty liver disease is an obesity-related disorder characterized by lipid infiltration of the liver. Management is limited to lifestyle modifications, highlighting the need for alternative therapeutic options. The objective of this study was to examine if fermented Fuzhuan tea prevents metabolic impairments associated with development of hepatic steatosis.
   Methods and results: Rats consumed control (CON) or high saturated fat (SAT) diets with or without Fuzhuan tea for 8 weeks. Outcomes included enzymatic and gene expression measures of metabolic dysregulation in liver and adipose tissue. Pyrosequencing was used to assess intestinal microbiota adaptations. Fuzhuan tea prevented diet-induced inflammation in the liver. Liver triglycerides of similar to 18 mg/g were observed in SAT-fed animals, but remained similar to CON diet levels (similar to 12 mg/g) when supplemented with Fuzhuan tea. In adipose tissue, tea treatment prevented SAT-induced inflammation and reduced plasma leptin approximately twofold. Fuzhuan tea also altered intestinal function and was associated with a threefold increase in two Lactobacillus spp.
   Conclusions: These data suggest that Fuzhuan tea protects against liver and adipose tissue stress induced by a high SAT diet and positively influences intestinal function. Further investigation of the molecular targets of Fuzhuan tea is warranted.
C1 [Foster, Michelle T.; Gentile, Christopher L.; Cox-York, Kimberly; Wei, Yuren; Wang, Dong; Estrada, Andrea L.; Reese, Lauren; Miller, Tirrel; Pagliassotti, Michael J.; Weir, Tiffany L.] Colorado State Univ, Dept Food Sci & Human Nutr, Ft Collins, CO 80523 USA.
C3 Colorado State University System; Colorado State University Fort Collins
RP Weir, TL (corresponding author), Colorado State Univ, Dept Food Sci & Human Nutr, Ft Collins, CO 80523 USA.
EM Tiffany.Weir@colostate.edu
RI Pagliassotti, Michael/AAV-8238-2021; Estrada, Andrea/HZH-3981-2023
FU NIH [7K01DK 087816]; CSU College of Health and Human Science Minigrant
FX We would like to thank Gretchen Moran and Brittany Barnett for
   assistance with animal care and terminations. Funding for this work was
   provided by NIH 7K01DK 087816 (M.T.F), and CSU College of Health and
   Human Science Minigrant (T.L.W.).
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NR 38
TC 61
Z9 71
U1 0
U2 105
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1613-4125
EI 1613-4133
J9 MOL NUTR FOOD RES
JI Mol. Nutr. Food Res.
PD MAY
PY 2016
VL 60
IS 5
BP 1213
EP 1220
DI 10.1002/mnfr.201500654
PG 8
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA DL8TN
UT WOS:000375914700023
PM 26890069
DA 2025-06-11
ER

PT J
AU Benmoussa, A
   Kientega, T
   Morel, S
   Cardin, GB
   Bérard, S
   Wajnberg, M
   Valtchev, P
   Masse, AB
   Curnier, D
   Krajinovic, M
   Laverdière, C
   Sinnett, D
   Levy, E
   Marcoux, S
   Rodier, F
   Marcil, V
AF Benmoussa, Abderrahim
   Kientega, Tibila
   Morel, Sophia
   Cardin, Guillaume B.
   Berard, Sophie
   Wajnberg, Mickael
   Valtchev, Petko
   Masse, Alexandre Blondin
   Curnier, Daniel
   Krajinovic, Maja
   Laverdiere, Caroline
   Sinnett, Daniel
   Levy, Emile
   Marcoux, Sophie
   Rodier, Francis
   Marcil, Valerie
TI Poor Diet Quality is Associated with Premature Senescence of the Immune
   System in Survivors of Childhood Acute Lymphoblastic Leukaemia
SO NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
LA English
DT Article
ID YOUNG-ADULT SURVIVORS; OXIDATIVE STRESS; CARDIOVASCULAR-DISEASE;
   METABOLIC SYNDROME; PHYSICAL-ACTIVITY; THYMIC FUNCTION; OBESITY; CANCER;
   RISK; INFLAMMATION
AB Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer. Contributory factors such as inflammation and oxidative stress, in response to drug therapies, may induce premature aging and cellular senescence with a severe impact on cardiometabolic health. Premature immunoaging through cellular senescence can lead to lower thymic output of T-cell lymphocytes translated into lower circulating T-cell receptor excision circles (TRECs). We hypothesized TRECs levels are associated with diet quality and impacted by oxidative and inflammatory status in survivors of childhood ALL (cALL). Adolescents and young adults cALL survivors from the PETALE cohort (n = 241, 22.1 +/- 6.3 years at diagnosis, 49.4% males) were assessed for TREC levels and adherence to six diet quality indexes. Healthy Diet Indicator (HDI) was associated with TREC levels (beta = 50.0, p = 0.005, adjusted p = 0.03). Interleukin-6 (IL-6) and C-reactive protein (CRP) were found negatively associated with TREC levels (beta = -80 and -80.1, p = 0.017 and 0.026, respectively) HDI. Further analysis revealed IL-6 and CRP to be moderating factors, but not mediators, of the association between HDI and TRECs. This study supports a positive impact of a healthy diet on premature aging of the immune system in survivors of cALL and unveils the moderating role of inflammation in this association.
C1 [Benmoussa, Abderrahim; Morel, Sophia; Berard, Sophie; Curnier, Daniel; Krajinovic, Maja; Levy, Emile; Marcil, Valerie] Univ Montreal, St Justine Univ Hlth Ctr, Res Ctr, Montreal, PQ, Canada.
   [Kientega, Tibila; Cardin, Guillaume B.; Marcoux, Sophie; Rodier, Francis] CRCHUM, Montreal, PQ, Canada.
   [Kientega, Tibila; Cardin, Guillaume B.; Marcoux, Sophie; Rodier, Francis] Inst Canc Montreal, Montreal, PQ, Canada.
   [Kientega, Tibila; Cardin, Guillaume B.; Rodier, Francis] Univ Montreal, Dept Radiol Radiooncol & Nucl Med, Montreal, PQ, Canada.
   [Wajnberg, Mickael; Valtchev, Petko; Masse, Alexandre Blondin] Univ Quebec A Montreal UQAM, Ctr Artificial intelligence Res, Dept Comp Sci, Montreal, PQ, Canada.
   [Curnier, Daniel] Univ Montreal, Dept Kinesiol, Montreal, PQ, Canada.
   [Krajinovic, Maja; Laverdiere, Caroline; Sinnett, Daniel] Univ Montreal, Dept Pediat, Montreal, PQ, Canada.
   [Levy, Emile; Marcil, Valerie] Univ Montreal, Dept Nutr, Montreal, PQ, Canada.
   [Marcoux, Sophie] Univ Montreal, Dept Publ Hlth & Prevent Med, Montreal, PQ, Canada.
C3 Universite de Montreal; Universite de Montreal; Universite de Montreal;
   Universite de Montreal; Universite de Montreal; Universite de Montreal;
   Universite de Montreal; Universite de Montreal
RP Marcil, V (corresponding author), CHU St Justine, Ctr Rech Azrieli, 3175 Cote St Catherine,Room 4-17-006, Montreal, PQ H3T 1C5, Canada.
EM valerie.marcil@umontreal.ca
RI Marcoux, Sophie/HKM-9696-2023; Benmoussa, Abderrahim/AAR-1642-2021
FU Institute of Cancer Research (ICR) of the Canadian Institutes of Health
   Research (CIHR) [TCF 118694]; Fonds de la Recherche du Quebec-Sante
   (FRQ-S); Cole Foundation; FRQ-S; FRQ-S junior II [33070]; ICM; Cole
   Foundation
FX This work was supported by the Institute of Cancer Research (ICR) of the
   Canadian Institutes of Health Research (CIHR), in collaboration with C17
   Council, Canadian Cancer Society (CCS), Cancer Research Society (CRS),
   Garron Family Cancer Center at the Hospital for Sick Children, Ontario
   Institute for Cancer Research (OICR) and Pediatric Oncology Group of
   Ontario (POGO) under grant [number TCF 118694]. AB holds a postdoctoral
   fellowship from the Fonds de la Recherche du Quebec-Sante (FRQ-S) and
   the Cole Foundation; SM holds a fellowship from FRQ-S; SB holds a
   fellowship from the FRQ-S; FR holds a FRQ-S junior II career awards
   [number 33070] and received sup-port from the ICM for this project; VM
   holds a FRQ-S junior II career awards and was funded by a Transition
   grant from the Cole Foundation. The sponsors were not involved in study
   design; in the collection, analysis and interpretation of data; in the
   writing of the report; and in the decision to submit the article for
   publication.
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NR 103
TC 1
Z9 1
U1 0
U2 0
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 0163-5581
EI 1532-7914
J9 NUTR CANCER
JI Nutr. Cancer
PD MAY 28
PY 2025
VL 77
IS 4-5
BP 490
EP 505
DI 10.1080/01635581.2025.2474263
EA MAR 2025
PG 16
WC Oncology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Nutrition & Dietetics
GA 0UG7R
UT WOS:001440844700001
PM 40059323
DA 2025-06-11
ER

PT J
AU Roy, D
   Ghosh, M
   Rangra, NK
AF Roy, Debajyoti
   Ghosh, Maitrayee
   Rangra, Naresh Kumar
TI Herbal Approaches to Diabetes Management: Pharmacological Mechanisms and
   Omics-Driven Discoveries
SO PHYTOTHERAPY RESEARCH
LA English
DT Review; Early Access
DE diabetes; herbal; multi-omics; pharmacological; phytochemical
ID GREEN TEA; METABOLIC SYNDROME; NATURAL-PRODUCTS; EPIGALLOCATECHIN
   GALLATE; OXIDATIVE STRESS; BERBERINE; INFLAMMATION; CURCUMIN; OBESITY;
   RATS
AB Diabetes mellitus is a chronic metabolic disorder marked by hyperglycemia, resistance to insulin, and impaired function of the pancreatic beta-cells; it advances into more serious complications like nephropathy, neuropathy, cardiovascular disease, and retinopathy; herbal medicine has indicated promise in not just mitigating the symptoms but also in managing the complications. This review would aim to evaluate the pharmacological aspect of the botanical therapies Anacardium occidentale, Allium sativum, Urtica dioica, and Cinnamomum zeylanicum, as well as their bioactive phytochemicals, quercetin, resveratrol, berberine, and epigallocatechin gallate (EGCG). In this review, we discuss their mechanisms for secreting the insulin sensitizers, carbohydrate-hydrolyzing enzymes, reduction in oxidative stress and effectiveness against diabetic complications-all through sensitivity to insulin. Great emphasis is laid on the integration of multi-omics technologies such as genomics, proteomics, metabolomics, and transcriptomics in the discovery of bioactive compounds. The nature of the technologies can evaluate the intrinsic complexities of herbal pharmacology and even identify therapeutic candidates. Finally, the review refers to the meagre clinical trials on the efficiency of these compounds in the metabolism of humans. High-quality future research, such as human large-scale trials, would be emphasized; improvement in the clinical validity of a drug might come from improved study design, better selection of potentially usable biomarkers, and enhanced safety profiles to guarantee efficacy with lessened risks.
C1 [Roy, Debajyoti; Ghosh, Maitrayee] CV Raman Global Univ, Fac Pharm, Bhubaneswar, Odisha, India.
   [Roy, Debajyoti] Chitkara Univ, Chitkara Coll Pharm, Rajpura, Punjab, India.
   [Ghosh, Maitrayee] Amity Univ Uttar Pradesh, Amity Inst Pharm, Dept Pharmaceut, Noida, Uttar Pradesh, India.
   [Rangra, Naresh Kumar] Chitkara Univ, Sch Pharm, Baddi, Himachal Prades, India.
C3 Chitkara University, Punjab; Amity University Noida
RP Roy, D (corresponding author), CV Raman Global Univ, Fac Pharm, Bhubaneswar, Odisha, India.; Roy, D (corresponding author), Chitkara Univ, Chitkara Coll Pharm, Rajpura, Punjab, India.
EM droy4896@gmail.com
RI ROY, DEBAJYOTI/LNR-0819-2024; Rangra, Naresh/AGT-2166-2022
OI Rangra, Naresh/0000-0001-6118-4710; Roy, Debajyoti/0000-0001-7273-3455
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NR 130
TC 0
Z9 0
U1 5
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0951-418X
EI 1099-1573
J9 PHYTOTHER RES
JI Phytother. Res.
PD 2024 DEC 17
PY 2024
DI 10.1002/ptr.8410
EA DEC 2024
PG 27
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA P5X3M
UT WOS:001378631000001
PM 39688013
DA 2025-06-11
ER

PT J
AU Bernacka, K
   Bednarska, K
   Starzec, A
   Mazurek, S
   Fecka, I
AF Bernacka, Karolina
   Bednarska, Katarzyna
   Starzec, Aneta
   Mazurek, Sylwester
   Fecka, Izabela
TI Antioxidant and Antiglycation Effects of Cistus x incanus Water
   Infusion, Its Phenolic Components, and Respective Metabolites
SO MOLECULES
LA English
DT Article
DE Cistus x incanus; polyphenols; flavonols; urolithins; antioxidants;
   glycation inhibitors; methylglyoxal trapping; PCA; PLS-DA
ID GLYCATION END-PRODUCTS; SERUM-ALBUMIN; HERBAL TEA; L.; ANTIBACTERIAL;
   FLAVONOIDS; GLYCOSIDES; QUERCETIN; STRESS; CHROMATOGRAPHY
AB Reactive oxygen and carbonyl species promote oxidative and carbonyl stress, and the development of diabetes, metabolic syndrome, cardiovascular diseases, and others. The traditional herb Cistus x incanus is known for its antioxidant properties; therefore, the current study aimed to assess how the chemical composition of a C. incanus water infusion corresponds with its antioxidative and antiglycative effects in vitro. The composition of infusions prepared from commercial products was analyzed with UHPLC-ESI-qTOF-MS. Total phenolics, flavonoids, and non-flavonoid polyphenols were determined. Antioxidant activity of infusions and selected polyphenols was investigated using DPPH, ABTS, and FRAP. Fluorometric measurements and methylglyoxal capture were performed to investigate the antiglycation activity. PCA and PLS-DA models were applied to explore the correlation between chemical and antioxidant results. The principal flavonoids in C. incanus were flavonols. In vitro tests revealed that a stronger antioxidant effect was demonstrated by plant material from Turkey rich in flavonoids, followed by Albania and Greece. Flavonols and ellagic acid displayed stronger antiradical and reducing power than EA-derived urolithins. Hyperoside was the most potent inhibitor of glycation. The results indicate that flavonoids are primarily responsible for rock rose antioxidant and antiglycation properties. PLS-DA modeling can be used to identify the origin of plant material with sensitivity and specificity exceeding 86%.
C1 [Bernacka, Karolina; Bednarska, Katarzyna; Starzec, Aneta; Fecka, Izabela] Wroclaw Med Univ, Fac Pharm, Dept Pharmacognosy & Herbal Med, Ul Borowska 211, PL-50556 Wroclaw, Poland.
   [Mazurek, Sylwester] Univ Wroclaw, Dept Chem, Lab Chemometr & Appl Spect, 14 F Joliot Curie, PL-50383 Wroclaw, Poland.
C3 Wroclaw Medical University; University of Wroclaw
RP Bernacka, K (corresponding author), Wroclaw Med Univ, Fac Pharm, Dept Pharmacognosy & Herbal Med, Ul Borowska 211, PL-50556 Wroclaw, Poland.
EM karolina.bernacka011@gmail.com;
   katarzyna.bednarska@student.umed.wroc.pl;
   aneta.starzec@student.umed.wroc.pl; sylwester.mazurek@chem.uni.wroc.pl;
   izabela.fecka@umw.edu.pl
RI Bernacka, Karolina/HJH-0570-2022; Fecka, Izabela/AAS-8974-2021
OI Bednarska, Katarzyna/0000-0002-9276-7879; Fecka,
   Izabela/0000-0002-1139-4581; Bernacka, Karolina/0000-0002-5985-3687
FU Wroclaw Medical University
FX The study was funded by Wroclaw Medical University, grant no.
   SUBZ.D110.22.019. UHPLC-ESI-qTOF-MS experiments were performed in the
   Laboratory of Elemental Analysis and Structural Research, Wroclaw
   Medical University. The technical assistance of Ruszkiewicz, M. and
   Czapor-Irzabek, H. is gratefully acknowledged.
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NR 79
TC 12
Z9 12
U1 1
U2 28
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 1420-3049
J9 MOLECULES
JI Molecules
PD APR
PY 2022
VL 27
IS 8
AR 2432
DI 10.3390/molecules27082432
PG 22
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 0R3EO
UT WOS:000785483000001
PM 35458630
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Yu, LL
   Liang, Q
   Zhang, WF
   Liao, MQ
   Wen, MH
   Zhan, BM
   Bao, H
   Cheng, XS
AF Yu, Lingling
   Liang, Qian
   Zhang, Weifang
   Liao, Minqi
   Wen, Minghua
   Zhan, Biming
   Bao, Huihui
   Cheng, Xiaoshu
TI HSP22 suppresses diabetes-induced endothelial injury by inhibiting
   mitochondrial reactive oxygen species formation
SO REDOX BIOLOGY
LA English
DT Article
DE Hyperglycemia; HSP22; Inflammation; mtROS; Oxidative stress; T2DM
ID H11 KINASE; INFLAMMASOME ACTIVATION; HIGH-GLUCOSE; PROTEIN; CELLS;
   DYSFUNCTION; APOPTOSIS; RISK; CRYSTALLIN; GROWTH
AB The induction of mitochondrial reactive oxygen species (mtROS) by hyperglycemia is a key event responsible for endothelial activation and injury. Heat shock protein 22 (HSP22) is a stress-inducible protein associated with cytoprotection and apoptosis inhibition. However, whether HSP22 prevents hyperglycemia-induced vascular endothelial injury remains unclear. Here, we investigated whether HSP22 protects the vascular endothelium from hyperglycemia-induced injury by reducing mtROS production. We used a high-fat diet and streptozotocin injection model to induce type 2 diabetes mellitus (T2DM, metabolic syndrome) and exposed human umbilical vein endothelial cells (HUVECs) to high glucose following overexpression or silencing of HSP22 to explore the role of HSP22. We found that HSP22 markedly inhibited endothelial cell activation and vascular lesions by inhibiting endothelial adhesion and decreasing cytokine secretion. We performed confocal microscopy and flow cytometry assays using HUVECs and showed that HSP22 attenuated mtROS and mitochondrial dysfunction in hyperglycemia-stimulated endothelial cells. Mechanistically, using the mtROS inhibitor MitoTEMPO, we demonstrated that HSP22 suppressed endothelial activation and injury by eliminating hyperglycemia-mediated increases in mtROS. Furthermore, we found that HSP22 maintained the balance of mitochondrial fusion and fission by mitigating mtROS in vitro. HSP22 attenuated the development of vascular lesions by suppressing mtROS-mediated endothelial activation in a T2DM mouse model. This study provides evidence that HSP22 may be a promising therapeutic target for vascular complications in T2DM.
C1 [Yu, Lingling; Liao, Minqi; Wen, Minghua; Zhan, Biming; Bao, Huihui; Cheng, Xiaoshu] Nanchang Univ, Dept Cardiol, Affiliated Hosp 2, 1 Minde Rd, Nanchang 330006, Jiangxi, Peoples R China.
   [Liang, Qian] Nanchang Univ, Key Lab Mol Biol Jiangxi Prov, Affiliated Hosp 2, Nanchang, Jiangxi, Peoples R China.
   [Zhang, Weifang] Nanchang Univ, Dept Pharm, Affiliated Hosp 2, Nanchang, Jiangxi, Peoples R China.
C3 Nanchang University; Nanchang University; Nanchang University
RP Bao, H; Cheng, XS (corresponding author), Nanchang Univ, Dept Cardiol, Affiliated Hosp 2, 1 Minde Rd, Nanchang 330006, Jiangxi, Peoples R China.
EM huihui_bao77@126.com; xiaoshumenfan@126.com
FU National Natural Science Foundation of China [81560051, 81260023,
   81460045, 1460010]; Science and Technology Planning Project of Jiangxi
   Province [2016YNQN12034]; China Postdoctoral Science Foundation
   [2017M622107]; Postdoctoral Science Foundation of Jiangxi Province
   [2016KY51]
FX This work was supported by grants from the National Natural Science
   Foundation of China (Nos. 81560051, 81260023, 81460045 and 1460010), the
   Science and Technology Planning Project of Jiangxi Province (No.
   2016YNQN12034), a China Postdoctoral Science Foundation funded project
   (2017M622107) and the Postdoctoral Science Foundation of Jiangxi
   Province (No. 2016KY51).
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NR 52
TC 47
Z9 51
U1 3
U2 21
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2213-2317
J9 REDOX BIOL
JI Redox Biol.
PD FEB
PY 2019
VL 21
AR 101095
DI 10.1016/j.redox.2018.101095
PG 12
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA HR1WN
UT WOS:000462926900027
PM 30640127
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Moine, L
   Rivoira, M
   de Barboza, GD
   Pérez, A
   de Talamoni, NT
AF Moine, Luciana
   Rivoira, Maria
   Diaz de Barboza, Gabriela
   Perez, Adriana
   Tolosa de Talamoni, Nori
TI Glutathione depleting drugs, antioxidants and intestinal calcium
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SO WORLD JOURNAL OF GASTROENTEROLOGY
LA English
DT Review
DE Glutathione; Transcellular and paracellular Ca2+ pathways;
   DL-buthionine-S,R-sulfoximine; Fructose rich diet; Menadione; Sodium
   deoxycholate; Glutamine; Ursodeoxycholic acid; Melatonin; Quercetin;
   Naringin
ID VITAMIN-D; OXIDATIVE STRESS; CA2+ ABSORPTION; BILE-ACID; DEOXYCHOLIC
   ACIDS; BONE METABOLISM; GENE-EXPRESSION; REDOX BIOLOGY; GLUTAMINE;
   MELATONIN
AB Glutathione (GSH) is a tripeptide that constitutes one of the main intracellular reducing compounds. The normal content of GSH in the intestine is essential to optimize the intestinal Ca2+ absorption. The use of GSH depleting drugs such as DL-buthionine-S,R-sulfoximine, menadione or vitamin K3, sodium deoxycholate or diets enriched in fructose, which induce several features of the metabolic syndrome, produce inhibition of the intestinal Ca2+ absorption. The GSH depleting drugs switch the redox state towards an oxidant condition provoking oxidative/nitrosative stress and inflammation, which lead to apoptosis and/or autophagy of the enterocytes. Either the transcellular Ca2+ transport or the paracellular Ca2+ route are altered by GSH depleting drugs. The gene and/or protein expression of transporters involved in the transcellular Ca2+ pathway are decreased. The flavonoids quercetin and naringin highly abrogate the inhibition of intestinal Ca2+ absorption, not only by restoration of the GSH levels in the intestine but also by their anti-apoptotic properties. Ursodeoxycholic acid, melatonin and glutamine also block the inhibition of Ca2+ transport caused by GSH depleting drugs. The use of any of these antioxidants to ameliorate the intestinal Ca2+ absorption under oxidant conditions associated with different pathologies in humans requires more investigation with regards to the safety, pharmacokinetics and pharmacodynamics of them.
C1 [Moine, Luciana; Rivoira, Maria; Diaz de Barboza, Gabriela; Perez, Adriana; Tolosa de Talamoni, Nori] Univ Nacl Cordoba, CONICET, Lab Dr Fernando Canas, Catedra Bioquim & Biol Mol,Fac Ciencias Med,INICS, Pabellon Argentina,2Do Piso,Ciudad Univ, RA-5000 Cordoba, Argentina.
C3 Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET);
   National University of Cordoba
RP de Talamoni, NT (corresponding author), Univ Nacl Cordoba, CONICET, Lab Dr Fernando Canas, Catedra Bioquim & Biol Mol,Fac Ciencias Med,INICS, Pabellon Argentina,2Do Piso,Ciudad Univ, RA-5000 Cordoba, Argentina.
EM ntolosa@biomed.fcm.unc.edu.ar
RI Moine, Luciana/AAA-5427-2021; Vieiro, Adriana/KFS-6926-2024
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NR 91
TC 21
Z9 28
U1 2
U2 18
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 8226 REGENCY DR, PLEASANTON, CA 94588 USA
SN 1007-9327
EI 2219-2840
J9 WORLD J GASTROENTERO
JI World J. Gastroenterol.
PD NOV 28
PY 2018
VL 24
IS 44
BP 4979
EP 4988
DI 10.3748/wjg.v24.i44.4979
PG 10
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA HB7CD
UT WOS:000451232400004
PM 30510373
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Xu, J
   Lee, ES
   Baek, SH
   Ahn, SY
   Kim, S
   Na, KY
   Chae, DW
   Chin, HJ
AF Xu, Jianwei
   Lee, Eun Seong
   Baek, Seon Ha
   Ahn, Shin-Young
   Kim, Sejoong
   Na, Ki Young
   Chae, Dong-Wan
   Chin, Ho Jun
TI Effect of Bilirubin on Triglyceride Synthesis in Streptozotocin-Induced
   Diabetic Nephropathy
SO JOURNAL OF KOREAN MEDICAL SCIENCE
LA English
DT Article
DE Bilirubin; Diabetes-Related Complications; Triglyceride; Fibrosis;
   Transforming Growth Factor beta
ID SERUM BILIRUBIN; METABOLIC SYNDROME; OXIDATIVE STRESS; GENE-EXPRESSION;
   RENAL-DISEASE; X-RECEPTOR; PROTEIN; LEVEL; RATS; SREBP-1
AB We aimed to elucidate the effect of bilirubin on dyslipidemia and nephropathy in a diabetes mellitus (DM) type I animal model. Sprague-Dawley rats were separated into control, DM, and bilirubin-treated DM (Bil) groups. The Bil group was injected intraperitoneally with 60 mg/kg bilirubin 3 times per week and hepatoma cells were cultured with bilirubin at a concentration of 0.3 mg/dL. The Bil group showed lower serum creatinine levels 5 weeks after diabetes onset. Bilirubin treatment also decreased the amount of mesangial matrix, lowered the expression of renal collagen IV and transforming growth factor (TGF)-beta 1, and reduced the level of apoptosis in the kidney, compared to the DM group. These changes were accompanied by decreased tissue levels of hydrogen superoxide and NADPH oxidase subunit proteins. Bilirubin decreased serum total cholesterol, high-density lipoprotein cholesterol (HDL-C), free fatty acids, and triglycerides (TGs), as well as the TG content in the liver tissues. Bilirubin suppressed protein expression of LXR alpha, SREBP-1, SCD-1, and FAS, factors involved in TG synthesis that were elevated in the livers of DM rats and hepatoma cells under high-glucose conditions. In conclusion, bilirubin attenuates renal dysfunction and dyslipidemia in diabetes by suppressing LXR alpha and SREBP-1 expression and oxidative stress.
C1 [Xu, Jianwei; Lee, Eun Seong; Baek, Seon Ha; Ahn, Shin-Young; Kim, Sejoong; Na, Ki Young; Chae, Dong-Wan; Chin, Ho Jun] Seoul Natl Univ, Bundang Hosp, Dept Internal Med, Songnam 463707, South Korea.
   [Xu, Jianwei; Na, Ki Young; Chae, Dong-Wan; Chin, Ho Jun] Seoul Natl Univ, Coll Med, Dept Internal Med, Seoul 151, South Korea.
   [Chin, Ho Jun] Seoul Natl Univ, Postgrad Sch, Dept Immunol, Seoul 151, South Korea.
   [Chin, Ho Jun] Seoul Natl Univ, Med Res Ctr, Renal Inst, Seoul, South Korea.
C3 Seoul National University (SNU); Seoul National University (SNU); Seoul
   National University (SNU); Seoul National University (SNU)
RP Chin, HJ (corresponding author), Seoul Natl Univ, Bundang Hosp, 82 Gumi Ro 173beon Gil, Songnam 463707, South Korea.
EM mednep@snubh.org
RI Chae, Dong-Wan/J-5681-2012; Chin, Ho/J-5678-2012; Na, Ki/J-5456-2012;
   Kim, Sejoong/J-5356-2015
OI Kim, Sejoong/0000-0002-7238-9962; Xu, Jinawei/0000-0001-8049-0422
FU Seoul National University Bundang Hospital [06-2012-117]
FX This research was supported by a grant (06-2012-117) from Seoul National
   University Bundang Hospital.
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NR 39
TC 16
Z9 16
U1 0
U2 5
PU KOREAN ACAD MEDICAL SCIENCES
PI SEOUL
PA 302 75 DONG DU ICHON, DONG YONGSAN KU, SEOUL 140 031, SOUTH KOREA
SN 1011-8934
EI 1598-6357
J9 J KOREAN MED SCI
JI J. Korean Med. Sci.
PD SEP
PY 2014
VL 29
SU 2
BP S155
EP S163
DI 10.3346/jkms.2014.29.S2.S155
PG 9
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA AS5OX
UT WOS:000344320900013
PM 25317020
OA gold, Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Li, YR
   Zhu, H
   Kauffman, M
   Danelisen, I
   Misra, HP
   Ke, YB
   Jia, ZQ
AF Li, Y. Robert
   Zhu, Hong
   Kauffman, Megan
   Danelisen, Igor
   Misra, Hara P.
   Ke, Yuebin
   Jia, Zhenquan
TI Paraoxonases function as unique protectors against cardiovascular
   diseases and diabetes: Updated experimental and clinical data
SO EXPERIMENTAL BIOLOGY AND MEDICINE
LA English
DT Review
DE Paraoxonase; pon enzymes; cardioprotection; cardiovascular diseases;
   diabetes; experimental animals
ID LOW-DENSITY-LIPOPROTEIN; E-DEFICIENT MICE; ADENOVIRUS-MEDIATED
   EXPRESSION; CORONARY-ARTERY-DISEASE; OXIDATIVE STRESS; GENE-EXPRESSION;
   PON1 GENE; SERUM PARAOXONASE; LIPID-PEROXIDATION; Q192R POLYMORPHISM
AB Paraoxonase (PON) refers to a family of three enzymes, namely PON1, PON2, and PON3. PON1 and PON3 are found in circulation bound to high-density lipoprotein, whereas PON2 is an intracellular protein. PON1 was first discovered as an enzyme to hydrolyze the organophosphate pesticide paraoxon, an activity that both PON2 and PON3 lack. All three PON enzymes are able to degrade oxidized lipids and protect against oxidative stress. PON enzymes also act to suppress inflammation. Animal studies show a critical role for PON enzymes, especially PON1 in protecting against cardiovascular diseases and related disorders, including diabetes and metabolic syndrome. In line with the findings in experimental animals, accumulating evidence from clinical research also indicates that PON enzymes function as potential protectors in human cardiovascular diseases and related disorders. Identification of PON enzymes as important players in cardiovascular health will facilitate the development of novel preventive and therapeutic modalities targeting PON enzymes to combat cardiovascular diseases and related disorders, which collectively constitute the chief contributors to the global burden of disease. This review describes the biochemical properties and molecular regulation of PON and summarizes the major recent findings on the functions of PON in protecting against cardiovascular diseases and related disorders.
C1 [Li, Y. Robert; Zhu, Hong; Danelisen, Igor] Campbell Univ, Sch Osteopath Med, Dept Pharmacol, Buies Creek, NC 27506 USA.
   [Li, Y. Robert] Wake Forest Univ, Virginia Tech, Sch Biomed Engineers & Sci, Blacksburg, VA 24061 USA.
   [Li, Y. Robert; Misra, Hara P.] Virginia Polytech Inst & State Univ, Dept Biomed Sci & Pathobiol, Blacksburg, VA 24061 USA.
   [Li, Y. Robert; Jia, Zhenquan] Univ N Carolina, Dept Biol, Greensboro, NC 27412 USA.
   [Kauffman, Megan] Wofford Coll, Spartanburg, SC 29303 USA.
   [Ke, Yuebin] Shenzhen Ctr Dis Control & Prevent, Shenzhen 518055, Peoples R China.
C3 Campbell University; Virginia Polytechnic Institute & State University;
   Wake Forest University; Virginia Polytechnic Institute & State
   University; University of North Carolina; University of North Carolina
   Greensboro; Shenzhen Center for Disease Control & Prevention (SZCDC)
RP Li, YR (corresponding author), Campbell Univ, Sch Osteopath Med, Dept Pharmacol, Buies Creek, NC 27506 USA.
EM yli@campbell.edu; z_jia@uncg.edu
FU National Institutes of Health (NIH) [HL093557, 7R15AT005372]
FX This work was supported by grants from the National Institutes of Health
   (NIH) grants HL093557 (YR Li) and 7R15AT005372 (Z Jia).
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NR 76
TC 8
Z9 9
U1 0
U2 5
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1535-3702
EI 1535-3699
J9 EXP BIOL MED
JI Exp. Biol. Med.
PD AUG
PY 2014
VL 239
IS 8
BP 899
EP 906
DI 10.1177/1535370214535897
PG 8
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA AQ4MR
UT WOS:000342772600001
PM 24903163
DA 2025-06-11
ER

PT J
AU Prasad, V
   Chirra, S
   Kohli, R
   Shull, GE
AF Prasad, Vikram
   Chirra, Shivani
   Kohli, Rohit
   Shull, Gary E.
TI NHE1 deficiency in liver: Implications for non-alcoholic fatty liver
   disease
SO BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
LA English
DT Article
DE NHE1; Steatohepatitis; Liver fibrosis; Insulin resistance; Metabolic
   syndrome; Obesity
ID ACETYL-COA CARBOXYLASE-2; INDUCED HEPATIC STEATOSIS; STELLATE CELL
   ACTIVATION; ALPHA-B-CRYSTALLIN; OXIDATIVE STRESS;
   HEPATOCELLULAR-CARCINOMA; X RECEPTOR; INSULIN-RESISTANCE;
   GENE-EXPRESSION; STEATOHEPATITIS
AB Non-alcoholic fatty liver disease NAFLD is closely associated with the dysregulation of lipid homeostasis. Diet-induced hepatic steatosis, which can initiate NAFLD progression, has been shown to be dramatically reduced in mice lacking the electroneutral Na+/H+ exchanger NHE1 (Slc9a1). In this study, we investigated if NHE1 deficiency had effects in liver that could contribute to the apparent protection against aberrant lipid accumulation. RT-PCR and immunoblot analyses of wild-type and NHE1-null livers revealed an expression profile that strongly suggested attenuation of both de nova lipogenesis and hepatic stellate cell activation, which is implicated in liver fibrosis. This included upregulation of the farnesoid X receptor FXR, peroxisome proliferator-activated receptor PPAR gamma, its co-activator PGC1 alpha, and sestrin 2, an antioxidant protein involved in hepatic metabolic homeostasis. Furthermore, expression levels of the pro-lipogenic liver X receptor LXR alpha, and acetyl CoA carboxylases 1 and 2 were downregulated. These changes were associated with evidence of reduced cellular stress, which persisted even upon exposure to a high-fat diet, and the better preservation of insulin signaling, as evidenced by protein kinase B/Akt phosphorylation (Ser473). These results indicate that NHE1 deficiency may protect against NAFLD pathogenesis, which is significant given the availability of highly specific NHE1 inhibitors. (C) 2014 Elsevier Inc. All rights reserved.
C1 [Prasad, Vikram; Chirra, Shivani; Shull, Gary E.] Univ Cincinnati, Coll Med, Dept Mol Genet Biochem & Microbiol, Cincinnati, OH 45267 USA.
   [Kohli, Rohit] Univ Cincinnati, Cincinnati Childrens Hosp, Dept Gastroenterol Hepatol & Nutr, Cincinnati, OH 45267 USA.
C3 University System of Ohio; University of Cincinnati; University System
   of Ohio; University of Cincinnati; Cincinnati Children's Hospital
   Medical Center
RP Prasad, V (corresponding author), Univ Cincinnati, Coll Med, Dept Mol Genet Biochem & Microbiol, 231 Albert Sabin Way, Cincinnati, OH 45267 USA.
EM prasadvm@ucmail.uc.edu
RI kohli, Rohit/H-3020-2013
OI kohli, Rohit/0000-0002-0198-7703
FU Cincinnati Diabetes and Obesity Center; American Heart Association
   [11BGIA7720005]; National Institutes of Health [DK050594]; American
   Heart Association (AHA) [11BGIA7720005] Funding Source: American Heart
   Association (AHA)
FX This work was funded by grants from the Cincinnati Diabetes and Obesity
   Center (V.P.) and American Heart Association (11BGIA7720005; V.P.), and
   National Institutes of Health (DK050594; G.E.S.). Technical assistance
   by Sowmya S. Balusu (supported by the University of Cincinnati Honors
   Biomedical Research and Mentoring Program) is gratefully acknowledged.
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NR 60
TC 17
Z9 21
U1 0
U2 4
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0006-291X
EI 1090-2104
J9 BIOCHEM BIOPH RES CO
JI Biochem. Biophys. Res. Commun.
PD JUL 25
PY 2014
VL 450
IS 2
BP 1027
EP 1031
DI 10.1016/j.bbrc.2014.06.095
PG 5
WC Biochemistry & Molecular Biology; Biophysics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics
GA AM4YD
UT WOS:000339861200017
PM 24976401
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Cui, WX
   Li, JJ
   Chen, XQ
   Mao, Q
   Wei, XL
   Wen, XD
   Yang, J
   Wang, Q
AF Cui, Wei-xi
   Li, Jing-Jing
   Chen, Xiao-qing
   Mao, Qian
   Wei, Xiang-lan
   Wen, Xiao-dong
   Yang, Jie
   Wang, Qiang
TI Ilexgenin A Obtained from Ilex hainanensis Merr. Improves Diet-Induced
   Non-Alcoholic Fatty Liver Disease in Rats
SO DRUG DEVELOPMENT RESEARCH
LA English
DT Article
DE nonalcoholic fatty liver disease; Ilexgenin A; insulin resistance;
   inflammation; oxidative stress
ID IN-SITU DETECTION; INSULIN-RESISTANCE; LIPID-PEROXIDATION; PPAR-ALPHA;
   INFLAMMATION; STEATOHEPATITIS; PATHWAY; WEIGHT; MODEL; MEN
AB Preclinical Research Nonalcoholic fatty liver disease (NAFLD) is a common aspect of metabolic syndrome, which includes a wide spectrum of liver damage and is closely associated with insulin resistance and lipid peroxidation. The current study aimed to evaluate the protective effect of Ilexgenin A (IA), obtained from Ilex hainanensis Merr., on NAFLD and investigate the underlying mechanisms. Sprague-Dawley rats were fed a high-fat (HF) diet for 3 weeks to induce NAFLD. They were divided into HF diet rats and HF-IA-treated rats, which were treated with IA (80mg/kg p.o.) for 2 weeks. IA alleviated hepatic steatosis and insulin resistance and reduced plasma levels of alanine transaminase, aspartate aminotransferase, triglyceride, total cholesterol, low-density lipoprotein-cholesterol, malondialdehyde, interleukin 6, and tumor necrosis factor-, while increasing plasma levels of high-density lipoprotein-cholesterol and superoxide dismutase (SOD). IA decreased hepatic triglycerides, total cholesterol, malondialdehyde, and restored the abnormal down-regulation of SOD. IA also decreased Cytochrome P450 2E1 expression and up-regulated peroxisome proliferator-activated receptor (PPAR) expression in liver. These results suggested that IA had the potential to attenuate NAFLD by improving lipid metabolism, insulin resistance, inflammation, and oxidative stress, as well as adjusting the expression of Cytochrome P450 2E1 and PPAR alpha. Drug Dev Res 74 : 227-236, 2013. (C) 2013 Wiley Periodicals, Inc.
C1 [Cui, Wei-xi; Li, Jing-Jing; Mao, Qian; Wen, Xiao-dong; Yang, Jie; Wang, Qiang] China Pharmaceut Univ, State Key Lab Nat Med, Nanjing 210009, Jiangsu, Peoples R China.
   [Chen, Xiao-qing] Capital Med Univ, Sch Tradit Chinese Med, Beijing 100069, Peoples R China.
   [Wei, Xiang-lan] Xian Chest & TB Hosp, Pharmaceut Preparat Sect, Xian, Shanxi, Peoples R China.
C3 China Pharmaceutical University; Capital Medical University
RP Wang, Q (corresponding author), China Pharmaceut Univ, State Key Lab Nat Med, Nanjing 210009, Jiangsu, Peoples R China.
EM cpusyj@163.com; qwang49@163.com
RI Chen, Xiaoqing/ABF-1482-2020
FU National Natural Science Foundation of China [81073039]; Natural Science
   Foundation of Jiangsu Province [BK2011627]; Fundamental Research Funds
   for the Central Universities [JKQ2009008, JKY2011074]; priority academic
   program development of Jiangsu higher education institutions (PAPD)
FX This work was supported by the National Natural Science Foundation of
   China (No. 81073039) and the Natural Science Foundation of Jiangsu
   Province, (No. BK2011627). It is also supported by the Fundamental
   Research Funds for the Central Universities (Program No. JKQ2009008 and
   No. JKY2011074). We also greatly appreciate the financial support from
   the priority academic program development of Jiangsu higher education
   institutions (PAPD).
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NR 33
TC 7
Z9 10
U1 0
U2 37
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0272-4391
EI 1098-2299
J9 DRUG DEVELOP RES
JI Drug Dev. Res.
PD JUN
PY 2013
VL 74
IS 4
BP 227
EP 236
DI 10.1002/ddr.21066
PG 10
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 160RF
UT WOS:000320136300001
OA Bronze
DA 2025-06-11
ER

PT J
AU Chung, TH
   Kim, JH
   Seol, SY
   Kim, YJ
   Lee, YJ
AF Chung, Tae-Ha
   Kim, Ji-Hye
   Seol, So-Young
   Kim, Yon-Ji
   Lee, Yong-Jae
TI The Effects of Korean Red Ginseng on Biological Aging and Antioxidant
   Capacity in Postmenopausal Women: A Double-Blind Randomized Controlled
   Study
SO NUTRIENTS
LA English
DT Article
DE Korean red ginseng; antioxidant activity; biological aging; fatigue;
   postmenopausal women
ID FATIGUE SEVERITY SCALE; OXIDATIVE STRESS; PANAX-GINSENG; METABOLIC
   SYNDROME; MENOPAUSE; EXTRACT; CELLS
AB Postmenopausal women are vulnerable to aging and oxidative stress due to reduced estrogen. Previous studies have shown that Korean red ginseng (KRG) has beneficial effects on aging and antioxidant capacity. Therefore, we evaluated the effects of KRG on biological aging and antioxidant capacity in postmenopausal women. This study conducted a double-blinded, placebo-controlled clinical trial. The participants were randomly administered KRG or a placebo, and the following metrics were measured: mitochondria DNA (mtDNA) copy number as an indicator of biological aging and, total antioxidant status (TAS) as a marker of antioxidant capacity. Clinical symptoms of fatigue, as measured by the fatigue severity scale, were assessed before and after KRG administration. There were 63 participants, of whom 33 received KRG and 30 received a placebo. The mtDNA copy number (KRG group: 1.58 +/- 2.05, placebo group: 0.28 +/- 2.36, p = 0.023) and TAS (KRG group: 0.11 +/- 0.25 mmol/L, placebo group: -0.04 +/- 0.16 mmol/L, p = 0.011) increased and the fatigue severity scale (KRG group: -7 +/- 12, placebo group: -1 +/- 11, p = 0.033) decreased significantly more in the KRG group than the placebo group. KRG significantly increased the mtDNA copy number, total antioxidant status, and improved symptoms of fatigue in postmenopausal women.
C1 [Chung, Tae-Ha] Yonsei Univ, Wonju Severance Christian Hosp, Dept Family Med, Wonju Coll Med, Wonju 26426, South Korea.
   [Chung, Tae-Ha] Yonsei Univ, Grad Sch Med, Dept Med, Seoul 03722, South Korea.
   [Kim, Ji-Hye; Kim, Yon-Ji] Yonsei Univ Hlth Syst, Dept Hlth Promot Severance Check Up, Seoul 03722, South Korea.
   [Seol, So-Young] Yonsei Univ, Gangnam Severance Hosp, Dept Internal Med, Biomed Res Ctr,Coll Med, Seoul 06273, South Korea.
   [Lee, Yong-Jae] Yonsei Univ, Gangnam Severance Hosp, Dept Family Med, Coll Med, Seoul 06273, South Korea.
C3 Yonsei University; Yonsei University; Yonsei University; Yonsei
   University Health System; Yonsei University; Yonsei University Health
   System; Yonsei University; Yonsei University Health System
RP Lee, YJ (corresponding author), Yonsei Univ, Gangnam Severance Hosp, Dept Family Med, Coll Med, Seoul 06273, South Korea.
EM medeus115@yonsei.ac.kr; bles4you@yuhs.ac; syseo10916@yuhs.ac;
   redyonji@gmail.com; ukyjhome@yuhs.ac
RI Lee, Yong Jae/GLR-4153-2022; Kim, Ji/AAN-5655-2021
OI Chung, Tae-Ha/0000-0001-5873-3352; KIM, YONJI/0000-0002-1127-3130; Lee,
   Yong-Jae/0000-0002-6697-476X; Kim, Ji-Hye/0000-0002-5719-8180
FU Korean Society of Ginseng [GS 305-354]
FX This study was supported by a 2018 research grant from the Korean
   Society of Ginseng (GS 305-354).
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NR 36
TC 25
Z9 27
U1 1
U2 4
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD SEP
PY 2021
VL 13
IS 9
AR 3090
DI 10.3390/nu13093090
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA UX9RU
UT WOS:000701173900001
PM 34578969
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Chiavarina, B
   Nokin, MJ
   Durieux, F
   Bianchi, E
   Turtoi, A
   Peulen, O
   Peixoto, P
   Irigaray, P
   Uchida, K
   Belpomme, D
   Delvenne, P
   Castronovo, V
   Bellahcène, A
AF Chiavarina, Barbara
   Nokin, Marie-Julie
   Durieux, Florence
   Bianchi, Elettra
   Turtoi, Andrei
   Peulen, Olivier
   Peixoto, Paul
   Irigaray, Philippe
   Uchida, Koji
   Belpomme, Dominique
   Delvenne, Philippe
   Castronovo, Vincent
   Bellahcene, Akeila
TI Triple negative tumors accumulate significantly less methylglyoxal
   specific adducts than other human breast cancer subtypes
SO ONCOTARGET
LA English
DT Article
DE methylglyoxal; breast cancer; advanced glycation end-products;
   Arg-pyrimidine adducts; glyoxalase 1
ID GLYCATION END-PRODUCTS; BROMOBENZYLGLUTATHIONE CYCLOPENTYL DIESTER;
   HUMAN PROSTATE-CANCER; GLYOXALASE-I; PROTEIN MODIFICATION; OXIDATIVE
   STRESS; GENE-EXPRESSION; CELL BIOLOGY; LUNG-CANCER; APOPTOSIS
AB Metabolic syndrome and type 2 diabetes are associated with increased risk of breast cancer development and progression. Methylglyoxal (MG), a glycolysis by-product, is generated through a non-enzymatic reaction from triose-phosphate intermediates. This dicarbonyl compound is highly reactive and contributes to the accumulation of advanced glycation end products. In this study, we analyzed the accumulation of Arg-pyrimidine, a MG-arginine adduct, in human breast adenocarcinoma and we observed a consistent increase of Arg-pyrimidine in cancer cells when compared with the non-tumoral counterpart. Further immunohistochemical comparative analysis of breast cancer subtypes revealed that triple negative lesions exhibited low accumulation of Arg-pyrimidine compared with other subtypes. Interestingly, the activity of glyoxalase 1 (Glo-1), an enzyme that detoxifies MG, was significantly higher in triple negative than in other subtype lesions, suggesting that these aggressive tumors are able to develop an efficient response against dicarbonyl stress. Using breast cancer cell lines, we substantiated these clinical observations by showing that, in contrast to triple positive, triple negative cells induced Glo-1 expression and activity in response to MG treatment. This is the first report that Argpyrimidine adduct accumulation is a consistent event in human breast cancer with a differential detection between triple negative and other breast cancer subtypes.
C1 [Chiavarina, Barbara; Nokin, Marie-Julie; Durieux, Florence; Turtoi, Andrei; Peulen, Olivier; Peixoto, Paul; Castronovo, Vincent; Bellahcene, Akeila] Univ Liege, Metastasis Res Lab, GIGA Canc, Liege, Belgium.
   [Bianchi, Elettra; Delvenne, Philippe] Univ Liege, Dept Anat & Pathol, Liege, Belgium.
   [Irigaray, Philippe; Belpomme, Dominique] Assoc Res & Treatments Canc ARTAC, Paris, France.
   [Uchida, Koji] Nagoya Univ, Grad Sch Bioagr Sci, Lab Food & Biodynam, Nagoya, Aichi 4648601, Japan.
C3 University of Liege; University of Liege; Nagoya University
RP Bellahcène, A (corresponding author), Univ Liege, Metastasis Res Lab, GIGA Canc, Liege, Belgium.
EM a.bellahcene@ulg.ac.be
RI Turtoi, Andrei/ABD-1271-2021; Peulen, Olivier/C-1250-2018
OI Peixoto, Paul/0000-0001-6302-7823; Turtoi, Andrei/0000-0003-3813-6635;
   Uchida, Koji/0000-0003-3894-5299; irigaray,
   philippe/0000-0003-3375-7192; belpomme, dominique/0000-0002-9132-2077;
   Peulen, Olivier/0000-0002-6933-0134
FU National Fund for Scientific Research (FNRS, Belgium); Centre
   Anti-Cancereux, University of Liege, Belgium
FX BC is a Televie Post-Doctoral Fellow, MJN is a Televie Fellow, AT is a
   Post-Doctoral Research Fellow and AB is a Senior Research Associate, all
   from the National Fund for Scientific Research (FNRS, Belgium). This
   work was also supported by the Centre Anti-Cancereux, University of
   Liege, Belgium. The authors are thankful to Prof. Talesa's laboratory
   (University of Perugia, Italy) and Pr. M-C De Pauw (University of Liege)
   for technical support for the measure of Glyoxalase 1 enzymatic activity
   and Mrs. N. Maloujahmoum for expert technical assistance with the cell
   culture. We also thank the Biotheque of the University of Liege - CHU
   Liege for providing human tumor samples.
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JI Oncotarget
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EP 5482
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WC Oncology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
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DA 2025-06-11
ER

PT J
AU Rajendran, A
   Minhas, AS
   Kazzi, B
   Varma, B
   Choi, E
   Thakkar, A
   Michos, ED
AF Rajendran, Aardra
   Minhas, Anum S.
   Kazzi, Brigitte
   Varma, Bhavya
   Choi, Eunjung
   Thakkar, Aarti
   Michos, Erin D.
TI Sex-specific differences in cardiovascular risk factors and implications
   for cardiovascular disease prevention in women
SO ATHEROSCLEROSIS
LA English
DT Review
DE Women 's cardiovascular health; Risk factors; Sex differences;
   Prevention; Pregnancy; Menopause; Autoimmune disease; Migraine
ID CORONARY-HEART-DISEASE; SYSTEMIC-LUPUS-ERYTHEMATOSUS;
   POLYCYSTIC-OVARY-SYNDROME; RECURRENT PREGNANCY LOSS; OF-THE-ART;
   RHEUMATOID-ARTHRITIS; MYOCARDIAL-INFARCTION; METABOLIC SYNDROME;
   DIABETES-MELLITUS; AGE
AB Cardiovascular disease (CVD) is the leading cause of mortality for women globally. Sex differences exist in the relative risks conferred by traditional CVD risk factors, including diabetes, hypertension, obesity, and smoking. Additionally, there are female-specific risk factors, including age of menarche and menopause, polycystic ovary syndrome, infertility and the use of assisted reproductive technology, spontaneous pregnancy loss, parity, and adverse pregnancy outcomes, as well as female-predominant conditions such as autoimmune diseases, migraines, and depression, that enhance women's cardiovascular risk across the lifespan. Along with measurement of traditional risk factors, these female-specific factors should also be ascertained as a part of cardiovascular risk assessment to allow for a more comprehensive overview of the risk for developing cardiometabolic disorders and CVD. When present, these factors can identify women at elevated cardiovascular risk, who may benefit from more intensive preventive interventions, including lifestyle changes and/or pharmacotherapy such as statins. This review describes sex differences in traditional risk factors and female-specific/female-predominant risk factors for CVD and examines the role of coronary artery calcium scores and certain biomarkers that can help further risk stratify patients and guide preventive recommendations.
C1 [Rajendran, Aardra; Kazzi, Brigitte; Varma, Bhavya; Thakkar, Aarti] Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD USA.
   [Minhas, Anum S.; Choi, Eunjung; Michos, Erin D.] Johns Hopkins Univ, Sch Med, Div Cardiol, Baltimore, MD 21205 USA.
C3 Johns Hopkins University; Johns Hopkins University
RP Michos, ED (corresponding author), Johns Hopkins Univ, Sch Med, Div Cardiol, Baltimore, MD 21205 USA.
EM edonnell@jhmi.edu
OI Michos, Erin/0000-0002-5547-5084
FU Amato Fund for Women's Cardiovascular Health at Johns Hopkins
   University; American Heart Association Award [946222]; NIH [KL2TR003099]
FX Dr. Michos is funded by the Amato Fund for Women's Cardiovascular Health
   at Johns Hopkins University and by an American Heart Association Award,
   Number: 946222. Dr. Minhas was supported by NIH KL2TR003099.
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SC Cardiovascular System & Cardiology
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DA 2025-06-11
ER

PT J
AU Gurbuz, N
   Mammadov, E
   Usta, MF
AF Gurbuz, Nilgun
   Mammadov, Elnur
   Usta, Mustafa Faruk
TI Hypogonadism and erectile dysfunction: an overview
SO ASIAN JOURNAL OF ANDROLOGY
LA English
DT Review
DE testosterone; erectile physiology; symptomatic late onset hypogonadism
ID FOLLICLE-STIMULATING-HORMONE; NOCTURNAL PENILE TUMESCENCE; FREE
   TESTOSTERONE LEVELS; SLEEP-RELATED ERECTIONS; SEXUAL FUNCTION;
   LUTEINIZING-HORMONE; ANDROGEN DEFICIENCY; METABOLIC SYNDROME; CAVERNOUS
   VASODILATION; BODY-COMPOSITION
AB In humans androgen decline is presented as a clinical picture which includes decreased sexual interest, diminished erectile capasity, delayed or absent orgasms and reduced sexual pleasure. Additionally, changes in mood, diminished well being, fatigue, depression and irritability are also associated with androgen insufficiency. The critical role of androgens on the development, growth, and maintanence of the penis has been widely accepted. Although, the exact effect of androgens on erectile physiology still remains undetermined, recent experimental studies have broaden our understanding about the relationship between androgens and erectile function. Preclinical studies showed that androgen deprivation leads to penile tissue atrophy and alterations in the nerve structures of the penis. Furthermore, androgen deprivation caused to accumulation of fat containing cells and decreased protein expression of endothelial and neuronal nitric oxide synthases (eNOS and nNOS), and phosphodiesterase type-5 (PDE-5), which play crucial role in normal erectile physiology. On the light of the recent literature, we aimed to present the direct effect of androgens on the structures, development and maintanence of penile tissue and erectile physiology as well. Furhermore, according to the clinical studies we conclude the aetiology, pathophysiology, prevalance, diagnosis and treatment options of hypogonadism in aging men.
C1 [Gurbuz, Nilgun; Mammadov, Elnur; Usta, Mustafa Faruk] Akdeniz Univ, Sch Med, Dept Urol, Sect Androl, TR-07058 Antalya, Turkey.
C3 Akdeniz University
RP Usta, MF (corresponding author), Akdeniz Univ, Sch Med, Dept Urol, Sect Androl, Dumlupinar Bulvari,Kampus 07070, TR-07058 Antalya, Turkey.
EM musta@akdeniz.edu.tr
RI USTA, MUSTAFA/I-8136-2017
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NR 72
TC 13
Z9 16
U1 0
U2 8
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, 400059, INDIA
SN 1008-682X
EI 1745-7262
J9 ASIAN J ANDROL
JI Asian J. Androl.
PD JAN 1
PY 2008
VL 10
IS 1
BP 36
EP 43
DI 10.1111/j.1745-7262.2008.00375.x
PG 8
WC Andrology; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Urology & Nephrology
GA 263LH
UT WOS:000253218100006
PM 18087642
OA gold
DA 2025-06-11
ER

PT J
AU Cavaliere, G
   Catapano, A
   Trinchese, G
   Cimmino, F
   Menale, C
   Petrella, L
   Mollica, MP
AF Cavaliere, Gina
   Catapano, Angela
   Trinchese, Giovanna
   Cimmino, Fabiano
   Menale, Ciro
   Petrella, Lidia
   Mollica, Maria Pina
TI Crosstalk between Adipose Tissue and Hepatic Mitochondria in the
   Development of the Inflammation and Liver Injury during Ageing in
   High-Fat Diet Fed Rats
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE inflammation; adipose tissue; liver diseases; mitochondrial function;
   adipocyte size
ID METABOLIC SYNDROME; OXIDATIVE STRESS; HUMAN OBESITY; ADIPONECTIN;
   DYSFUNCTION; MECHANISM; EXPRESSION; BALANCE; LEPTIN; STATE
AB Obesity is considered an epidemic disorder, due to an imbalance between energy consumption and metabolizable energy intake. This balance is increasingly disrupted during normal aging processes due to the progressive impairment of mechanisms that normally control energy homeostasis. Obesity is triggered by an excessive lipid depots but reflects systemic inflammation along with large adipocytes secreting proinflammatory adipokines, an increase of the free fatty acids levels in the bloodstream, and ectopic lipid accumulation. Hepatic fat accumulation is the most common cause of chronic liver disease, characterized by mitochondrial dysfunction with a consequent impaired fat metabolism and increased oxidative stress. Therefore, mitochondrial dysfunction is associated to hepatic lipid accumulation and related complications. In this study, we assessed the crosstalk between adipose tissue and liver, analyzing the time-course of changes in hepatic mitochondrial fatty acid oxidation capacity versus fatty acid storage, focusing on the contribution of adipose tissue inflammation to hepatic lipid accumulation, using a rodent model of high fat diet-induced obesity. Our results demonstrate that both high-fat diet-induced obesity and aging induce dysregulation of adipose tissue function and similar metabolic alterations mediated by mitochondrial function impairment and altered inflammatory profile. The high fat diet-induced obesity anticipates and exacerbates liver mitochondrial dysfunction that occurs with aging processes.
C1 [Cavaliere, Gina] Univ Perugia, Dept Pharmaceut Sci, I-06126 Perugia, Italy.
   [Cavaliere, Gina; Catapano, Angela; Cimmino, Fabiano; Mollica, Maria Pina] Complesso Univ Monte Sant Angelo, Ctr Servizi Metrol & Tecnol Avanzati CeSMA, Via Cinthia 21, I-80126 Naples, Italy.
   [Catapano, Angela; Trinchese, Giovanna; Cimmino, Fabiano; Petrella, Lidia; Mollica, Maria Pina] Univ Naples Federico II, Dept Biol, I-80126 Naples, Italy.
   [Menale, Ciro] Univ Naples Federico II, Dept Clin Med & Surg, I-80131 Naples, Italy.
   [Mollica, Maria Pina] Univ Naples Federico II, Task Force Microbiome Studies, I-80138 Naples, Italy.
C3 University of Perugia; University of Naples Federico II; University of
   Naples Federico II; University of Naples Federico II
RP Mollica, MP (corresponding author), Complesso Univ Monte Sant Angelo, Ctr Servizi Metrol & Tecnol Avanzati CeSMA, Via Cinthia 21, I-80126 Naples, Italy.; Mollica, MP (corresponding author), Univ Naples Federico II, Dept Biol, I-80126 Naples, Italy.; Mollica, MP (corresponding author), Univ Naples Federico II, Task Force Microbiome Studies, I-80138 Naples, Italy.
EM mariapia.mollica@unina.it
RI Giovanna, Trinchese/AAC-5995-2022; CIMMINO, FABIANO/AIA-1152-2022;
   Catapano, Angela/GXV-0918-2022; Menale, Ciro/J-2855-2014
OI CATAPANO, ANGELA/0000-0002-0429-8348; Menale, Ciro/0000-0001-5782-2089;
   TRINCHESE, Giovanna/0000-0002-4096-6876; Cavaliere,
   Gina/0000-0001-5890-1002; Petrella, Lidia/0000-0002-5084-5760; CIMMINO,
   FABIANO/0000-0001-5239-4329
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NR 62
TC 11
Z9 11
U1 2
U2 22
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD FEB
PY 2023
VL 24
IS 3
AR 2967
DI 10.3390/ijms24032967
PG 16
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 8V1SL
UT WOS:000930418400001
PM 36769289
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Oosthuizen, W
   Malan, L
   Scheepers, JD
   Cockeran, M
   Malan, NT
AF Oosthuizen, Woudri
   Malan, Leone
   Scheepers, Jacobus D.
   Cockeran, Marike
   Malan, Nicolaas T.
TI The defense response and alcohol intake: A coronary artery disease risk?
   The SABPA Study
SO CLINICAL AND EXPERIMENTAL HYPERTENSION
LA English
DT Article
DE Alcohol; coping; ethnicity; gamma-glutamyl transferase; silent ischemia
ID PULSE PRESSURE; BLOOD-PRESSURE; HYPERTENSION; HEALTH; POPULATION;
   MARKERS; GENETICS; MEN
AB The behavioral defense coping response (DefS) as a measure of coping with emotional stress may increase alcohol intake (gamma glutamyl transferase (GT)), the risk for coronary artery disease (CAD) and insulin sensitivity (homeostasis model assessment, HOMA). We assessed associations between coping and cardiometabolic risk markers in a bi-ethnic cohort (N = 390) from South Africa. Ambulatory blood pressure (BP) and ECG, fasting blood and coping scores were obtained. Africans, and mostly when utilizing DefS, showed higher 24h BP, a low-grade inflammatory state, central obesity, increased HOMA [4.07 (3.66, 4.47)] and more ST events compared to their Caucasian counterparts. ROC -GT analyses predicting 24-h ambulatory hypertension showed a higher -GT cut-point in Africans (55.4 U/l) than in Caucasians (19.5 U/l). Odds ratios (ORs) of -GT cut-points predicting 24-h ambulatory hypertension was evident in DefS African men [OR: 7.37 (95% CI: 6.71-8.05), p = 0.003] and in DefS Caucasians, albeit at a lower -GT cut-point (19.5 U/l). Higher -GT cut-points in DefS Africans or Caucasians were not associated with HOMA > 3. DefS accompanied by alcohol abuse in taxing emotional situations, if no social support is forthcoming, underscores a profile of reduced coronary perfusion. It may enhance vasoconstriction of the coronary arteries, with compensatory increases in BP, and induce a risk for future coronary artery disease.
C1 [Oosthuizen, Woudri; Malan, Leone; Scheepers, Jacobus D.; Malan, Nicolaas T.] North West Univ, Sch Physiol Nutr & Consumer Sci, HART, Potchefstroom, South Africa.
   [Cockeran, Marike] North West Univ, MUSA, Potchefstroom, South Africa.
C3 North West University - South Africa; North West University - South
   Africa
RP Oosthuizen, W (corresponding author), North West Univ, Fac Hlth Sci, HART, Private Bag X6001, ZA-2520 Potchefstroom, South Africa.
EM Leone.Malan@nwu.ac.za
RI Malan, Leone/Q-8187-2019; Scheepers, Kobus/ITW-2350-2023; Malan,
   Leone/D-7203-2014
OI Scheepers, Kobus/0000-0003-0372-4496; Malan, Leone/0000-0003-3187-2410;
   Cockeran, Marike/0000-0002-3990-8345
FU Metabolic Syndrome Institute, France; Roche Diagnostics; Medical
   Research Council; National Research Foundation; North-West University;
   North-West Department of Education, South Africa
FX Research was partly funded by The Metabolic Syndrome Institute, France;
   Roche Diagnostics; Medical Research Council; National Research
   Foundation, North-West University, and North-West Department of
   Education, South Africa. The funding organizations played no role in the
   design and conduct of the study, nor in the preparation, review, or
   approval of the manuscript.
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NR 43
TC 11
Z9 12
U1 0
U2 4
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1064-1963
EI 1525-6006
J9 CLIN EXP HYPERTENS
JI Clin. Exp. Hypertens.
PY 2016
VL 38
IS 6
BP 526
EP 532
DI 10.3109/10641963.2016.1163372
PG 7
WC Pharmacology & Pharmacy; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Pharmacology & Pharmacy; Cardiovascular System & Cardiology
GA DT3UJ
UT WOS:000381406300006
PM 27399032
DA 2025-06-11
ER

PT J
AU Deshmukh, N
   Phansopkar, P
AF Deshmukh, Nikita
   Phansopkar, Pratik
TI Individualized conservative treatment for medial tibial stress syndrome:
   A case study
SO MEDICAL SCIENCE
LA English
DT Article
DE Shin splits; pain; physiotherapeutic rehabilitation; lower extremity
   injury; medial tibial stress syndrome
ID ANKLE DORSIFLEXION RANGE; PHYSIOTHERAPY; TREADMILL; IMPACT; TESTS
AB Recreational runners, military trainers, dancers, and individuals who jump or move quickly are the main cause of shin splints. It is most commonly known as overuse injury. The most commonly impacted areas of the tibia are the anterior and posterior. In this condition medial side is most commonly affected, or antero- lateral side and sometime both of the side is painful which was difficult to diagnose. Overuse of the foot flexors, as well as leg discomfort and stiffness. If not addressed, it might lead to major complications like nerve entrapment, compartment syndrome, soleus syndrome. X-ray investigation aids in the identification of the damaged portion, MRI finding which help to confirmed soft tissue involvement and CT scan for sensitive structure. While physiotherapeutic rehabilitation aids in the improvement of the condition and speedy recovery. Early conservative treatment helps to decreases the progression of the symptoms. The goal of this case study is to inform readers about the conservative treatment options available for shin splints. Make recommendations to enhance the treatment and functioning results of the patient.
C1 [Deshmukh, Nikita; Phansopkar, Pratik] Datta Meghe Inst Med Sci, Ravi Nair Physiotherapy Coll, Dept Musculoskeletal Physiotherapy, Wardha, Maharashtra, India.
C3 Datta Meghe Institute of Higher Education & Research (Deemed to be
   University); Ravi Nair Physiotherapy College (RNPC)
RP Deshmukh, N (corresponding author), Datta Meghe Inst Med Sci, Ravi Nair Physiotherapy Coll, Dept Musculoskeletal Physiotherapy, Wardha, Maharashtra, India.
EM nikitadesh09@gmail.com; drpratik77@gmail.com
RI Phansopkar, Pratik/AAX-5884-2020
OI Phansopkar, Pratik/0000-0003-3635-8840
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NR 20
TC 0
Z9 0
U1 2
U2 12
PU DISCOVERY PUBLICATION
PI TAMILNADU
PA KANYAKUMARI DISTRICT, TAMILNADU, 00000, INDIA
SN 2321-7359
EI 2321-7367
J9 MED SCI
JI Med. Sci.
PD JUN
PY 2022
VL 26
IS 124
AR ms229e2257
DI 10.54905/disssi/v26i124/ms229e2257
PG 7
WC Medicine, Research & Experimental
WE Emerging Sources Citation Index (ESCI)
SC Research & Experimental Medicine
GA 3F5IY
UT WOS:000830704000008
OA Bronze
DA 2025-06-11
ER

PT J
AU Fond, G
   Berna, F
   Andrianarisoa, M
   Godin, O
   Leboyer, M
   Brunel, L
   Aouizerate, B
   Capdevielle, D
   Chereau, I
   D'Amato, T
   Denizot, H
   Dubertret, C
   Dubreucq, J
   Faget, C
   Gabayet, F
   Llorca, PM
   Mallet, J
   Misdrahi, D
   Passerieux, C
   Richieri, R
   Rey, R
   Schandrin, A
   Urbach, M
   Vidailhet, P
   Boyer, L
   Schürhoff, F
AF Fond, G.
   Berna, F.
   Andrianarisoa, M.
   Godin, O.
   Leboyer, M.
   Brunel, L.
   Aouizerate, B.
   Capdevielle, D.
   Chereau, I.
   D'Amato, T.
   Denizot, H.
   Dubertret, C.
   Dubreucq, J.
   Faget, C.
   Gabayet, F.
   Llorca, P. M.
   Mallet, J.
   Misdrahi, D.
   Passerieux, C.
   Richieri, R.
   Rey, R.
   Schandrin, A.
   Urbach, M.
   Vidailhet, P.
   Boyer, L.
   Schurhoff, F.
CA FACE-SZ FondaMental Academic Cente
TI Chronic low-grade peripheral inflammation is associated with severe
   nicotine dependence in schizophrenia: results from the national
   multicentric FACE-SZ cohort
SO EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
LA English
DT Article
DE Schizophrenia; Nicotine dependence; Tobacco smoking; Inflammation;
   Antidepressant
ID C-REACTIVE PROTEIN; ACETYLCHOLINE-RECEPTOR; METABOLIC SYNDROME; BIPOLAR
   DISORDER; OXIDATIVE STRESS; TOBACCO SMOKING; OBESITY; DEPRESSION;
   MARKERS
AB Chronic peripheral inflammation (CPI) has been associated with cognitive impairment in schizophrenia (SZ). However, its sources remain unclear, more specifically it is not known whether tobacco smoking is a source of inflammation or not in SZ subjects. Moreover, nicotine (NIC), the major psychoactive compound of tobacco, shows strong anti-inflammatory properties in vitro, as well as inducing a severe biological dependence when administered repeatedly. The objective of the present study was to determine if CPI was associated with tobacco smoking and/or NIC dependence in schizophrenia. Three hundred and forty five stabilized community-dwelling SZ subjects aged 16 years or older (mean age = 32 years, 73% male) were consecutively included in the network of the FondaMental Expert Centers for Schizophrenia and assessed with validated scales. CPI was defined by a highly sensitive C-reactive protein (hsCRP) ae<yen>3 mg/L. Current tobacco status was self-declared. Severe NIC dependence was defined by a Fagerstrom Test for Nicotine Dependence score ae<yen>7. Overall, 159 (46.1%) were non-smokers, 117 (33.9%) and 69 (20%) were current tobacco smokers with, respectively, low and severe nicotine dependence. In a multivariate model, CPI remained associated with severe NIC dependence (29 vs 15%, OR = 2.8, p = 0.003) and body mass index (OR = 1.1, p < 0.0001), independently of socio-demographic characteristics and antidepressant intake. No association of CPI with low to moderate tobacco smoking dependence, number of daily smoked cigarettes, cannabis use, alcohol use or illness characteristics was found (all p > 0.05). CPI was associated with severe NIC dependence but not with tobacco smoking with low to moderate NIC dependence in SZ, independently of socio-demographic variables, body mass index, alcohol consumption and antidepressant intake. This result highlights the potential CPI consequences of the high prevalence of heavy tobacco smoking in SZ, indicating the importance of new therapeutic strategies for tobacco cessation in SZ.
C1 [Fond, G.; Berna, F.; Andrianarisoa, M.; Godin, O.; Leboyer, M.; Brunel, L.; Aouizerate, B.; Capdevielle, D.; Chereau, I.; D'Amato, T.; Denizot, H.; Dubertret, C.; Dubreucq, J.; Faget, C.; Gabayet, F.; Llorca, P. M.; Mallet, J.; Misdrahi, D.; Passerieux, C.; Richieri, R.; Rey, R.; Schandrin, A.; Urbach, M.; Vidailhet, P.; Boyer, L.; Schurhoff, F.] Fdn FondaMental, Creteil, France.
   [Andrianarisoa, M.; Leboyer, M.; Brunel, L.; Schurhoff, F.] INSERM U955, Equipe Psychiat Translat, Creteil, France.
   [Andrianarisoa, M.; Leboyer, M.; Brunel, L.; Schurhoff, F.] Univ Paris Est Creteil, DHU Pe PSY, Hop Univ H Mondor, Pole Psychiat, Creteil, France.
   [Boyer, L.] CHU St Marguerite, Pole Psychiat Univ, F-13274 Marseille 09, France.
   [Aouizerate, B.; Misdrahi, D.] Univ Bordeaux, Ctr Hosp Charles Perrens, F-33076 Bordeaux, France.
   [Berna, F.; Vidailhet, P.] Univ Strasbourg, Hop Univ Strasbourg, INSERM U1114, Federat Med Translat Strasbourg, Strasbourg, France.
   [Capdevielle, D.; Schandrin, A.] Univ Montpellier I, CHRU Montpellier, Hop Colombiere, Serv Univ Psychiat,Inserm, F-1061 Montpellier, France.
   [Chereau, I.; Denizot, H.; Llorca, P. M.] Univ Auvergne, Fac Med, CMP B, CHU,EA 7280, BP 69, F-63003 Clermont Ferrand 1, France.
   [D'Amato, T.; Rey, R.] Univ Claude Bernard Lyon 1, Ctr Rech Neurosci Lyon, INSERM U1028, CNRS UMR5292,Equipe PSYR2,Ctr Hosp Le Vinatier,Po, 95 Bd Pinel,BP 30039, F-69678 Bron, France.
   [Dubertret, C.; Mallet, J.] Univ Paris Diderot, Sorbonne Paris Cite, Louis Mourier Hosp, AP HP,Dept Psychiat,Inserm U894,Fac Med, Colombes, France.
   [Dubreucq, J.; Gabayet, F.] CH Alpes Isere, Ctr Referent Rehabil Psychosociale, Grenoble, France.
   [Faget, C.; Richieri, R.] Pole Univ Psychiat, AP HM, Marseille, France.
   [Passerieux, C.; Urbach, M.] Univ Versailles St Quentin En Yvelines, UFR Sci Sante Simone Veil, Ctr Hosp Versailles, Serv Psychiat Adulte, Versailles, France.
   [Aouizerate, B.] Bordeaux Univ, Pellegrin Univ Hosp, Bordeaux Sleep Clin, USR CNRS SANPSY 3413,Res Unit, F-33000 Bordeaux, France.
   [Aouizerate, B.] INSERM, Neuroctr Magendie, Physiopathol Plasticite Neuronale, U862, F-33000 Bordeaux, France.
   [Misdrahi, D.] INCIA, CNRS UMR 5287, Bordeaux, France.
   [Fond, G.] Hop Prive Parisien, Clin Jeanne dArc, St Mande, France.
   [Fond, G.] CHU Caremeau, Nimes, France.
   [Godin, O.] UPMC Univ Paris 06, UMRS 943, F-75013 Paris, France.
   [Godin, O.] INSERM, UMRS 943, F-75013 Paris, France.
C3 Universite Paris-Est-Creteil-Val-de-Marne (UPEC); Institut National de
   la Sante et de la Recherche Medicale (Inserm); Assistance Publique
   Hopitaux Paris (APHP); Universite Paris-Est-Creteil-Val-de-Marne (UPEC);
   Hopital Universitaire Henri-Mondor - APHP; Aix-Marseille Universite;
   Universite de Bordeaux; CHU Strasbourg; Universites de Strasbourg
   Etablissements Associes; Universite de Strasbourg; Institut National de
   la Sante et de la Recherche Medicale (Inserm); Universite de
   Montpellier; Institut National de la Sante et de la Recherche Medicale
   (Inserm); CHU de Montpellier; Universite Clermont Auvergne (UCA); CHU
   Clermont Ferrand; Centre National de la Recherche Scientifique (CNRS);
   CNRS - National Institute for Biology (INSB); Institut National de la
   Sante et de la Recherche Medicale (Inserm); Universite Claude Bernard
   Lyon 1; Universite Jean Monnet; Institut National de la Sante et de la
   Recherche Medicale (Inserm); Universite Paris Cite; Assistance Publique
   Hopitaux Paris (APHP); Hopital Universitaire Louis-Mourier - APHP;
   Aix-Marseille Universite; Assistance Publique-Hopitaux de Marseille;
   Universite Paris Saclay; Centre Hospitalier de Versailles; Universite de
   Bordeaux; Centre National de la Recherche Scientifique (CNRS); CNRS -
   National Institute for Biology (INSB); CHU Bordeaux; Institut National
   de la Sante et de la Recherche Medicale (Inserm); Universite de
   Bordeaux; Centre National de la Recherche Scientifique (CNRS);
   Universite de Bordeaux; CNRS - National Institute for Biology (INSB);
   Universite de Montpellier; CHU de Nimes; Sorbonne Universite; Institut
   National de la Sante et de la Recherche Medicale (Inserm)
RP Fond, G (corresponding author), Fdn FondaMental, Creteil, France.; Fond, G (corresponding author), Hop Prive Parisien, Clin Jeanne dArc, St Mande, France.; Fond, G (corresponding author), CHU Caremeau, Nimes, France.
EM guillaume.fond@gmail.com
RI Boyer, Laurent/E-5728-2016; Capdevielle, Delphine/HTO-4229-2023; Mallet,
   Jasmina/GNP-7160-2022; Fond, Guillaume/D-7646-2011; Leboyer,
   Marion/AAW-3648-2021; Berna, Fabrice/J-2701-2019; Schandrin,
   Aurélie/ISV-4608-2023; richieri, raphaelle/E-4707-2015; TESSIER,
   Arnaud/A-4022-2017
OI TESSIER, Arnaud/0000-0001-5758-5693; dubreucq,
   julien/0000-0003-4079-4194; LEBOYER, Marion/0000-0001-5473-3697;
   RICHIERI, Raphaelle/0000-0002-3901-7016; Misdrahi,
   David/0000-0003-1146-3206; Aouizerate, Bruno/0000-0002-7092-7747;
   Capdevielle, Delphine/0000-0002-7146-8554; D'Amato,
   Thierry/0000-0001-8983-0315; REY, Romain/0000-0002-4603-3575
FU AP-HP (Assistance Publique des Hopitaux de Paris); Fondation FondaMental
   (RTRS Sante Mentale); Investissements d'Avenir program
   [ANR-11-IDEX-0004-02, ANR-10-COHO-10-01]; INSERM (Institut National de
   la Sante et de la Recherche Medicale)
FX This work was funded by AP-HP (Assistance Publique des Hopitaux de
   Paris), Fondation FondaMental (RTRS Sante Mentale), by the
   Investissements d'Avenir program managed by the ANR under reference
   ANR-11-IDEX-0004-02 and ANR-10-COHO-10-01, and by INSERM (Institut
   National de la Sante et de la Recherche Medicale). We express all our
   thanks to the nurses, and to the patients who were included in the
   present study. We thank Hakim Laouamri, and his team (Stephane Beaufort,
   Seif Ben Salem, Karmene Souyris, Victor Barteau and Mohamed Laaidi) for
   the development of the FACE-SZ computer interface, data management,
   quality control and regulatory aspects.
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NR 46
TC 16
Z9 17
U1 0
U2 8
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0940-1334
EI 1433-8491
J9 EUR ARCH PSY CLIN N
JI Eur. Arch. Psych. Clin. Neurosci.
PD AUG
PY 2017
VL 267
IS 5
BP 465
EP 472
DI 10.1007/s00406-017-0771-4
PG 8
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA FA8CL
UT WOS:000405673700010
PM 28238173
DA 2025-06-11
ER

PT J
AU Bravo, L
   Martínez-López, S
   Sierra-Cinos, JL
   Mateos, R
   Sarriá, B
AF Bravo, Laura
   Martinez-Lopez, Sara
   Sierra-Cinos, Jose Luis
   Mateos, Raquel
   Sarria, Beatriz
TI Yerba Mate (Ilex paraguariensis St. Hill.) Tea May Have
   Cardiometabolic Beneficial Effects in Healthy and At-Risk Subjects: A
   Randomized, Controlled, Blind, Crossover Trial in Nonhabitual Consumers
SO MOLECULAR NUTRITION & FOOD RESEARCH
LA English
DT Article; Early Access
DE cardiometabolic risk; glucose homeostasis; hypercholesterolemia;
   inflammation; serum antioxidant capacity
ID OXIDATIVE STRESS BIOMARKERS; LC-MSN CHARACTERIZATION; ANTIOXIDANT
   ACTIVITY; IN-VITRO; CARDIOVASCULAR RISK; INSULIN-RESISTANCE; GREEN
   COFFEE; EXTRACT; GLUCOSE; FOOD
AB Yerba mate has been reported to have antihypertensive, hypocholesterolemic, antidiabetic, or antiobesity properties. Most evidences from human trials involved intakes of high amounts of mate by habitual consumers. Considering its increasing popularity, this study aimed at assessing the potential cardiometabolic effects of moderate intake of yerba mate by nonhabitual consumers. A randomized, crossover, controlled study was carried out in healthy and hypercholesterolemic subjects. Anthropometric parameters, blood pressure, blood lipids, glucose metabolism, inflammatory cytokines, chemokines, and different markers of endothelial function, as well as incretins, adipocytokines, and different hormones were measured at baseline and after 8 weeks consuming yerba mate or a decaffeinated isotonic drink (control). After daily consumption of three servings of mate tea, blood pressure, inflammatory cytokines, chemokines, and colony-stimulating factors decreased in all participants. LDL-C decreased in normocholesterolemic individuals, while the mate and control interventions elicited similar hypolipidemic action in the hypercholesterolemic group. Ghrelin and glucose-dependent insulinotropic polypeptide (GIP) significantly decreased after mate intake, while glucagon-like peptide 1 (GLP-1) and adipocytokines remained unchanged. Body fat percentage and tricipital skinfold decreased only in healthy subjects, with no effects on total body weight. In conclusion, yerba mate could exert cardiometabolic protective effects in healthy consumers and in subjects at moderate cardiovascular risk.Trial Registration: This trial was retrospectively registered in ClinicalTrials (NCT06729905)
C1 [Bravo, Laura; Martinez-Lopez, Sara; Mateos, Raquel; Sarria, Beatriz] CSIC, Inst Food Sci Technol & Nutr ICTAN, Dept Metab & Nutr, Madrid, Spain.
   [Martinez-Lopez, Sara; Sierra-Cinos, Jose Luis; Sarria, Beatriz] Univ Complutense Madrid, Sch Pharm, Dept Nutr & Food Sci, Madrid, Spain.
   [Sierra-Cinos, Jose Luis] Univ Int Isabel I Burgos Ui1, Sch Hlth Sci, Dept Hlth Sci, Burgos, Spain.
   [Mateos, Raquel] Inst Salud Carlos III ISCIII, CIBER Diabet & Enfermedades Metabol Asociadas CIBE, Madrid, Spain.
C3 Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Instituto
   de Ciencia y Tecnologia de Alimentos y Nutricion (ICTAN); Complutense
   University of Madrid
RP Bravo, L (corresponding author), CSIC, Inst Food Sci Technol & Nutr ICTAN, Dept Metab & Nutr, Madrid, Spain.
EM lbravo@ictan.csic.es
RI BRIZ, Raquel/H-9125-2012
FU Spanish Ministry of Economy and Competitivity [AGL2010-18269]; Spanish
   Research Agency [PID2020-114102RB-I00]; Spanish National Research
   Council - European Social Fund
FX This study was funded by the Spanish Ministry of Economy and
   Competitivity (project AGL2010-18269) and Spanish Research Agency
   (project PID2020-114102RB-I00); and a predoctoral fellowship granted by
   the Spanish National Research Council under the JAE-Pre Program, funded
   by the European Social Fund to S.M-L
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NR 102
TC 0
Z9 0
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1613-4125
EI 1613-4133
J9 MOL NUTR FOOD RES
JI Mol. Nutr. Food Res.
PD 2025 APR 22
PY 2025
DI 10.1002/mnfr.70065
EA APR 2025
PG 19
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA 1RZ5O
UT WOS:001472261700001
PM 40263915
DA 2025-06-11
ER

PT J
AU Rijks, J
   Karnebeek, K
   van Dijk, JW
   Dorenbos, E
   Gerver, WJ
   Stouthart, P
   Plat, J
   Vreugdenhil, A
AF Rijks, Jesse
   Karnebeek, Kylie
   van Dijk, Jan-Willem
   Dorenbos, Elke
   Gerver, Willem-Jan
   Stouthart, Pauline
   Plat, Jogchum
   Vreugdenhil, Anita
TI Glycaemic Profiles of Children With Overweight and Obesity in
   Free-living Conditions in Association With Cardiometabolic Risk
SO SCIENTIFIC REPORTS
LA English
DT Article
ID IMPAIRED GLUCOSE-TOLERANCE; OXIDATIVE STRESS; INSULIN-RESISTANCE;
   DIABETES-MELLITUS; ENDOTHELIAL-CELLS; PLASMA-GLUCOSE; HYPERGLYCEMIA;
   ADOLESCENTS; DISEASE; ONSET
AB Insulin resistance is common among children with overweight and obesity. However, knowledge about glucose fluctuations in these children is scarce. This study aims to evaluate glycaemic profiles in children with overweight and obesity in free-living conditions, and to examine the association between glycaemic profiles with insulin resistance and cardiovascular risk parameters. One hundred eleven children with overweight and obesity were included. 48-hour sensor glucose concentrations in free-living conditions, fasting plasma and post-glucose load concentrations, serum lipid and lipoprotein concentrations, homeostatic model assessment of insulin resistance (HOMA-IR), and blood pressure were evaluated. Hyperglycaemic glucose excursions (>= 7.8 mmol/L) were observed in 25% (n = 28) of the children. The median sensor glucose concentration was 5.0 (2.7-7.3) mmol/L, and correlated with fasting plasma glucose concentrations (r(s) = 0.190, p = 0.046), serum insulin concentrations (r(s) = 0.218, p = 0.021), and HOMA-IR (r(s) = 0.230, p = 0.015). The hyperglycaemic area under the curve (AUC) correlated with waist circumference z-score (r(s) = 0.455, p = 0.025), triacylglycerol concentrations (r(s) = 0.425, p = 0.024), and HOMA-IR (r(s) = 0.616, p < 0.001). In conclusion, hyperglycaemic glucose excursions are frequently observed in children with overweight and obesity in free-living conditions. Children with insulin resistance had higher median sensor glucose concentrations and a larger hyperglycaemic sensor glucose AUC, which are both associated with specific parameters predicting cardiovascular disease risk.
C1 [Rijks, Jesse; Karnebeek, Kylie; Dorenbos, Elke; Gerver, Willem-Jan; Stouthart, Pauline; Vreugdenhil, Anita] Maastricht Univ, Med Ctr, Dept Paediat, Ctr Overweight Adolescent & Childrens Healthcare, Maastricht, Netherlands.
   [Rijks, Jesse; Karnebeek, Kylie; Dorenbos, Elke; Gerver, Willem-Jan; Plat, Jogchum; Vreugdenhil, Anita] Maastricht Univ, Sch Nutr & Translat Res Metab NUTRIM, Maastricht, Netherlands.
   [van Dijk, Jan-Willem] HAN Univ Appl Sci, Inst Sports & Exercise Studies, Nijmegen, Netherlands.
   [Plat, Jogchum] Maastricht Univ, Dept Human Biol, Maastricht, Netherlands.
C3 Maastricht University; Maastricht University; Maastricht University
RP Vreugdenhil, A (corresponding author), Maastricht Univ, Med Ctr, Dept Paediat, Ctr Overweight Adolescent & Childrens Healthcare, Maastricht, Netherlands.; Vreugdenhil, A (corresponding author), Maastricht Univ, Sch Nutr & Translat Res Metab NUTRIM, Maastricht, Netherlands.
EM a.vreugdenhil@mumc.nl
RI van Dijk, Jan-Willem/AAH-6344-2020
OI van Dijk, Jan-Willem/0000-0001-9674-1505
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NR 34
TC 12
Z9 14
U1 0
U2 6
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD AUG 18
PY 2016
VL 6
AR 31892
DI 10.1038/srep31892
PG 9
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA DT6AB
UT WOS:000381563700001
PM 27534260
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Iakoubova, OA
   Haji-Sheikhi, F
   Louie, JZ
   Rowland, CM
   Arellano, AR
   Bare, LA
   Birse, CE
   Penn, MS
AF Iakoubova, Olga A.
   Haji-Sheikhi, Farnoosh
   Louie, Judy Z.
   Rowland, Charles M.
   Arellano, Andre R.
   Bare, Lance A.
   Birse, Charles E.
   Penn, Marc S.
TI Association of MPO levels with cardiometabolic disease stratified by
   atherosclerotic cardiovascular risk and intensity of therapy in a
   workforce population
SO SCIENTIFIC REPORTS
LA English
DT Article
DE Myeloperoxidase; eGFR; Liver fibrosis
ID CHRONIC KIDNEY-DISEASE; FATTY LIVER-DISEASE; CORONARY-ARTERY-DISEASE;
   PLASMA MYELOPEROXIDASE; MULTIPLE BIOMARKERS; OXIDATIVE STRESS;
   INFLAMMATION; PREDICTION; MORTALITY; SEVERITY
AB Cardiometabolic risk increases cardiovascular (CVD), chronic kidney (CKD) and non-alcoholic fatty liver (NAFLD) disease risk. High myeloperoxidase (MPO) levels identify individuals at risk for CVD. We whether elevation of MPO associated with kidney and liver disease risk in subgroups stratified by ASCVD risk and intensity of therapy. Adjusted logistic models assessed the associations of MPO with markers of kidney disease (estimated glomerular filtration rate) and liver fibrosis (NAFLD score > 0.676 or Fibrosis-4 [FIB-4] score > 2.67) across ASCVD risk (low < 7.5%; intermediate 7.5% to < 20%; high >= 20%). This retrospective study comprised 20,772 participants in an employer-sponsored health assessment. High MPO associated with impaired kidney function with low (OR 2.2, 95% CI 1.6-3.7) and intermediate (OR 2.0, 95% CI 1.3-3.5) ASCVD risk, and with high FIB-4 or NAFLD scores in low (OR 2.4, 95% CI 1.2-4.7), intermediate (OR 3.1, 95% CI 2.0-6.0), and high (OR 3.8, 95% CI 2.9-7.4) ASCVD risk groups. High MPO was associated with markers of CKD and liver fibrosis in low to intermediate ASCVD risk and treated groups. These findings demonstrate the commonality of cardiometabolic biomarkers across multiple organs. Prospective studies are warranted to assess whether high MPO levels identify persons at risk for CKD and liver fibrosis who may benefit from preventive strategies.
C1 [Iakoubova, Olga A.; Haji-Sheikhi, Farnoosh; Louie, Judy Z.; Rowland, Charles M.; Arellano, Andre R.; Bare, Lance A.; Birse, Charles E.] Quest Diagnost, 33608 Ortega Highway, San Juan Capistrano, CA 92675 USA.
   [Penn, Marc S.] Summa Hlth, Summa Hlth Heart & Vasc Inst, 525 E Market St, Akron, OH 44304 USA.
C3 Quest Diagnostics Inc; Summa Health System
RP Penn, MS (corresponding author), Summa Hlth, Summa Hlth Heart & Vasc Inst, 525 E Market St, Akron, OH 44304 USA.
EM marc.s.penn@gmail.com
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NR 56
TC 0
Z9 0
U1 4
U2 4
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD APR 10
PY 2025
VL 15
IS 1
AR 12244
DI 10.1038/s41598-025-89373-7
PG 8
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 1GY3C
UT WOS:001464772800003
PM 40210927
DA 2025-06-11
ER

PT J
AU Ichimura-Shimizu, M
   Kojima, M
   Suzuki, S
   Miyata, M
   Osaki, Y
   Matsui, K
   Mizui, T
   Tsuneyama, K
AF Ichimura-Shimizu, Mayuko
   Kojima, Masami
   Suzuki, Shingo
   Miyata, Misaki
   Osaki, Yui
   Matsui, Konomi
   Mizui, Toshiyuki
   Tsuneyama, Koichi
TI Brain-derived neurotrophic factor knock-out mice develop non-alcoholic
   steatohepatitis
SO JOURNAL OF PATHOLOGY
LA English
DT Article
DE brain-derived neurotrophic factor; non-alcoholic steatohepatitis;
   non-alcoholic fatty liver disease; liver fibrosis; RNA sequencing; gene
   ontology; mouse model
ID ENERGY-BALANCE; BDNF; OBESITY; LEPTIN; INFLAMMATION; HYPERPHAGIA;
   PROGRESSION
AB While brain-derived neurotrophic factor (BDNF), which is a growth factor associated with cognitive improvement and the alleviation of depression symptoms, is known to regulate food intake and body weight, the role of BDNF in peripheral disease is not fully understood. Here, we show that reduced BDNF expression is associated with weight gain and the chronic liver disease non-alcoholic steatohepatitis (NASH). At 10 months of age, BDNF-heterozygous (BDNF+/-) mice developed symptoms of NASH: centrilobular/perivenular steatosis, lobular inflammation with infiltration of neutrophils, ballooning hepatocytes, and fibrosis of the liver. Obesity and higher serum levels of glucose and insulin - major pathologic features in human NASH - were dramatic. Dying adipocytes were surrounded by macrophages in visceral fat, suggesting that chronic inflammation occurs in peripheral organs. RNA sequencing (RNA-seq) studies of the liver revealed that the most significantly enriched Gene Ontology term involved fatty acid metabolic processes and the modulation of neutrophil aggregation, pathologies that well characterise NASH. Gene expression analysis by RNA-seq also support the notion that BDNF+/- mice are under oxidative stress, as indicated by alterations in the expression of the cytochrome P450 family and a reduction in glutathione S-transferase p, an antioxidant enzyme. Histopathologic phenotypes of NASH were also observed in a knock-in mouse (BDNF+/pro), in which the precursor BDNF is inefficiently converted into the mature form of BDNF. Lastly, as BDNF reduction causes overeating and subsequent obesity, a food restriction study was conducted in BDNF+/pro mice. Pair-fed BDNF+/pro mice developed hepatocellular damage and showed infiltration of inflammatory cells, including neutrophils in the liver, despite having body weights and blood parameters that were comparable to those of controls. This is the first report demonstrating that reduced BDNF expression plays a role in the pathogenic mechanism of NASH, which is a hepatic manifestation of metabolic syndrome. (c) 2023 The Pathological Society of Great Britain and Ireland.
C1 [Ichimura-Shimizu, Mayuko; Osaki, Yui; Tsuneyama, Koichi] Tokushima Univ, Dept Pathol & Lab Med, Grad Sch, Tokushima, Japan.
   [Kojima, Masami; Miyata, Misaki] Kanazawa Inst Technol, Coll Biosci & Chem, Dept Appl Biosci, Nonoichi, Ishikawa, Japan.
   [Kojima, Masami; Matsui, Konomi; Mizui, Toshiyuki] Natl Inst Adv Ind Sci & Technol, Biomed Res Inst, Osaka, Japan.
   [Kojima, Masami; Mizui, Toshiyuki] Japan Sci & Technol Agcy JST, Core Res Evolut Sci & Technol CREST, Kawaguchi, Japan.
   [Suzuki, Shingo] Kagawa Univ, Fac Med, Dept Anat & Neurobiol, Takamatsu, Kagawa, Japan.
   [Suzuki, Shingo] Natl Inst Adv Ind Sci & Technol, Hlth & Med Res Inst, Takamatsu, Japan.
   [Kojima, Masami] Kanazawa Inst Technol, Coll Biosci & Chem, Dept Appl Biosci, 3-1 Yatsukaho, Haku San, Ishikawa 9240838, Japan.
C3 Tokushima University; Kanazawa Institute of Technology; National
   Institute of Advanced Industrial Science & Technology (AIST); Japan
   Science & Technology Agency (JST); Kagawa University; National Institute
   of Advanced Industrial Science & Technology (AIST); Kanazawa Institute
   of Technology
RP Kojima, M (corresponding author), Kanazawa Inst Technol, Coll Biosci & Chem, Dept Appl Biosci, 3-1 Yatsukaho, Haku San, Ishikawa 9240838, Japan.
EM masamikojima@neptune.kanazawa-it.ac.jp
RI Ichimura-Shimizu, Mayuko/KFT-1304-2024
OI Ichimura-Shimizu, Mayuko/0000-0003-4030-1249
FU Grants-in-Aid for Scientific Research [22K07024] Funding Source: KAKEN
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NR 44
TC 3
Z9 3
U1 0
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-3417
EI 1096-9896
J9 J PATHOL
JI J. Pathol.
PD DEC
PY 2023
VL 261
IS 4
BP 465
EP 476
DI 10.1002/path.6204
EA OCT 2023
PG 12
WC Oncology; Pathology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Pathology
GA Y2CA1
UT WOS:001080271200001
PM 37781961
DA 2025-06-11
ER

PT J
AU Schoorlemmer, RMM
   Peeters, GMEE
   van Schoor, NM
   Lips, P
AF Schoorlemmer, R. M. M.
   Peeters, G. M. E. E.
   van Schoor, N. M.
   Lips, P.
TI Relationships between cortisol level, mortality and chronic diseases in
   older persons
SO CLINICAL ENDOCRINOLOGY
LA English
DT Article
ID SALIVARY CORTISOL; GENDER-DIFFERENCES; METABOLIC SYNDROME; ALLOSTATIC
   LOAD; PLASMA-CORTISOL; SERUM CORTISOL; BIRTH-WEIGHT; ADULT LIFE; STRESS;
   AGE
AB P>Context
   High cortisol level is known to be associated with osteoporosis, hypertension, diabetes mellitus (DM), susceptibility to infections and depression and may protect against chronic obstructive pulmonary disease.
   Objective
   This study assesses the association between cortisol level, 6- to 7 center dot 5-year mortality risk and prevalence of chronic diseases.
   Design/setting/participants
   Subjects were selected from the Longitudinal Aging Study Amsterdam, an ongoing multidisciplinary cohort study in a general population of older persons (>= 65 years). Serum cortisol was measured in 1181 men and women in 1995/1996 (second cycle) and salivary cortisol in 998 men and women in 2001/2002 (fourth cycle).
   Main outcome measures
   Six to seven and a half year mortality and prevalence of chronic diseases.
   Results
   Men with high salivary morning cortisol had a higher mortality risk than men with low levels [hazard ratio (HR) = 1 center dot 63, P = 0 center dot 04 for the third vs. the lowest tertile]. Women with high salivary evening cortisol had a higher mortality risk than women with low levels (HR = 1 center dot 82, P = 0 center dot 04 for the third vs. the lowest tertile). In men, high serum cortisol was independently associated with chronic nonspecific lung disease (CNSLD): odds ratio (OR) = 0 center dot 72, P < 0 center dot 01; hypertension: OR = 1 center dot 38, P < 0 center dot 01; DM: OR = 1 center dot 38, P = 0 center dot 02. In women, high salivary evening cortisol was independently associated with DM: OR = 1 center dot 33, P = 0 center dot 01 and CNSLD: OR = 0 center dot 58, P = 0 center dot 02. No independent association between cortisol and number of chronic diseases was found.
   Conclusion
   High salivary cortisol levels are associated with increased mortality risk in a general older population. High cortisol levels are associated with higher risks of hypertension and DM and lower risk of CNSLD.
C1 [Lips, P.] Vrije Univ Amsterdam, Dept Endocrinol, Med Ctr, NL-1007 MD Amsterdam, Netherlands.
   [Schoorlemmer, R. M. M.; Peeters, G. M. E. E.; van Schoor, N. M.; Lips, P.] Vrije Univ Amsterdam, EMGO Inst, Med Ctr, NL-1007 MD Amsterdam, Netherlands.
C3 Vrije Universiteit Amsterdam; Vrije Universiteit Amsterdam
RP Lips, P (corresponding author), Vrije Univ Amsterdam, Dept Endocrinol, Med Ctr, Postbus 7057, NL-1007 MD Amsterdam, Netherlands.
EM p.lips@vumc.nl
RI Peeters, Geeske/G-3314-2010
OI Peeters, Geeske/0000-0003-4460-7026; van Schoor,
   Natasja/0000-0002-0870-0795
FU Dutch Ministry of Public Health, Welfare and Sports
FX This study was based on data from the Longitudinal Aging Study Amsterdam
   ( LASA), which is financially supported by the Dutch Ministry of Public
   Health, Welfare and Sports.
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NR 47
TC 93
Z9 109
U1 0
U2 10
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0300-0664
EI 1365-2265
J9 CLIN ENDOCRINOL
JI Clin. Endocrinol.
PD DEC
PY 2009
VL 71
IS 6
BP 779
EP 786
DI 10.1111/j.1365-2265.2009.03552.x
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 517PK
UT WOS:000271628100005
PM 19226268
DA 2025-06-11
ER

PT J
AU Mandrioli, R
   Protti, M
   Mercolini, L
AF Mandrioli, Roberto
   Protti, Michele
   Mercolini, Laura
TI Evaluation of the pharmacokinetics, safety and clinical efficacy of
   ziprasidone for the treatment of schizophrenia and bipolar disorder
SO EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY
LA English
DT Review
DE atypical antipsychotic; bipolar disorder; pharmacokinetics;
   pharmacotherapy; schizophrenia; ziprasidone
ID PLACEBO-CONTROLLED TRIAL; GENERALIZED ANXIETY DISORDER; MAJOR DEPRESSIVE
   DISORDER; 1ST-EPISODE NONAFFECTIVE PSYCHOSIS; TREATMENT-RESISTANT
   SCHIZOPHRENIA; NATURALISTIC OBSERVATIONAL TRIAL; MULTIPLE-DOSE
   PHARMACOKINETICS; ADJUNCTIVE ORAL ZIPRASIDONE; RANDOMIZED
   CONTROLLED-TRIAL; RECENT-ONSET SCHIZOPHRENIA
AB Introduction: Multiple strategies exist for the pharmacological treatment of schizophrenia and related disorders. In the last 20 years, several 'new' compounds have been introduced, called 'atypical antipsychotics', which have higher efficacy and better tolerability than first-generation neuroleptics. Among them, ziprasidone (ZPR) is currently finding widespread use, and it has also been shown to be active as an augmenter in bipolar disorder therapy.
   Areas covered: This review aims to provide the latest information on ZPR, an 'atypical' agent for the pharmacological therapy of schizophrenia and bipolar disorder. A literature search has been carried out with the keywords 'ziprasidone', 'schizophrenia', 'psychosis', 'bipolar', 'pharmacokinetics' and 'clinical trials'. In this process, particular attention has been paid to the drug pharmacokinetic characteristics and its safety in clinical use.
   Expert opinion: ZPR shares most advantages and disadvantages with other atypical antipsychotics. However, it can be useful for its low tendency to cause metabolic syndrome and hyperprolactinaemia, especially in patients suffering from excess weight, hyperlipidaemia, diabetes or who have suffered from hyperprolactinaemia when using other antipsychotics. However, there are serious doubts as to whether ZPR should be administered to patients suffering from arrhythmias or QTc prolongation, and even more for administration to bipolar patients undergoing polypharmacy with antidepressants.
C1 [Mandrioli, Roberto] Alma Mater Studiorum Univ Bologna, Dept Life Qual Studies QuVi, I-47921 Rimini, Italy.
   [Mandrioli, Roberto; Protti, Michele; Mercolini, Laura] Alma Mater Studiorum Univ Bologna, Interdipartmental Ctr Ind Res Adv Applicat Mech E, I-40136 Bologna, Italy.
   [Protti, Michele; Mercolini, Laura] Alma Mater Studiorum Univ Bologna, Dept Pharm & Biotechnol FaBiT, Lab Pharmaco Toxicol Anal, I-40126 Bologna, Italy.
C3 University of Bologna; University of Bologna; University of Bologna
RP Mandrioli, R (corresponding author), Alma Mater Studiorum Univ Bologna, Dept Life Qual Studies QuVi, Corso Augusto 237, I-47921 Rimini, Italy.
EM roberto.mandrioli@unibo.it
RI Protti, Michele/L-8288-2016; Mandrioli, Roberto/A-4535-2011
OI Protti, Michele/0000-0001-9310-4957; Mandrioli,
   Roberto/0000-0001-9631-591X; MERCOLINI, LAURA/0000-0002-0644-9461
FU Interdepartmental Centre for Industrial Research - Advanced Applications
   in Mechanical Engineering and Materials Technology (CIRI-MAM), Bologna;
   POR-FESR funds (Emilia-Romagna Region, Italy)
FX R Mandrioli and L Mercolini are employed by University of Bologna. M
   Protti has received a grant from Interdepartmental Centre for Industrial
   Research - Advanced Applications in Mechanical Engineering and Materials
   Technology (CIRI-MAM), Bologna, with POR-FESR funds (Emilia-Romagna
   Region, Italy). The authors have no other relevant affiliations or
   financial involvement with any organization or entity with a financial
   interest in or financial conflict with the subject matter or materials
   discussed in the manuscript apart from those disclosed. This includes
   employment, consultancies, honoraria, stock ownership or options, expert
   testimony, grants or patents received or pending, or royalties.
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   US Department of Health & Human Services Food and Drug Administration Center for Drug Evaluation and Research, NDA 20 825 APPR LETT
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NR 200
TC 12
Z9 12
U1 0
U2 28
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1742-5255
EI 1744-7607
J9 EXPERT OPIN DRUG MET
JI Expert Opin. Drug Metab. Toxicol.
PD JAN
PY 2015
VL 11
IS 1
BP 149
EP 174
DI 10.1517/17425255.2015.991713
PG 26
WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology
GA AW4EZ
UT WOS:000346235200013
PM 25483358
DA 2025-06-11
ER

PT J
AU Kim, GE
   Seidler, E
   Kimball, AB
AF Kim, G. E.
   Seidler, E.
   Kimball, A. B.
TI The relative impact of psoriasis and obesity on socioeconomic and
   medical outcomes in psoriasis patients
SO JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
LA English
DT Article
ID BODY-MASS INDEX; LIFE QUALITY INDEX; METABOLIC SYNDROME; SUBSTANCE USE;
   OF-LIFE; DERMATOLOGY; PREVALENCE; OUTPATIENTS; DISORDERS
AB BackgroundPsoriasis is a chronic, inflammatory skin disorder that is associated with obesity. Independently, both psoriasis and obesity likely impose impressive physical and psychosocial burdens on affected patients.
   ObjectiveThe purpose of this study was to evaluate the relative impact of body mass index (BMI) on the socioeconomic status, medical co-morbidities, and current and chronic quality of life of psoriasis patients.
   MethodsOverall, 114 subjects were examined and asked to complete a self-administered questionnaire regarding disabilities, relationships, education, as well as medical and economic outcomes. Participants also answered the ten questions used in the Dermatology Life Quality Index modified to ask over the last week', over the last year' and over your lifetime with psoriasis'. Survey responses were compared amongst the three patient groups based on BMI (normal, overweight, obese).
   ResultsPatients with elevated BMI were more likely to rate their general health lower (P<0.001), believe that psoriasis caused their weight gain (P=0.014), experience sleep problems over their lifetime (P=0.016), hide their psoriasis over their lifetime (P=0.010), have their self-confidence affected by their psoriasis over their lifetime (P=0.011) and avoid common activities over their lifetime (P=0.012).
   ConclusionThere are long-term negative effects of elevated BMI that impose additional burdens on psoriasis patients, including impairments in sleep quality and increased social anxiety.
C1 [Kim, G. E.; Kimball, A. B.] Harvard Univ, Sch Med, Dept Dermatol, Boston, MA 02115 USA.
   [Seidler, E.] Emory Univ, Sch Med, Atlanta, GA USA.
   [Kimball, A. B.] Massachusetts Gen Hosp, Clin Unit Res Trials & Outcomes Skin CURTIS, Boston, MA 02114 USA.
C3 Harvard University; Harvard Medical School; Emory University; Harvard
   University; Harvard University Medical Affiliates; Massachusetts General
   Hospital
RP Kimball, AB (corresponding author), Harvard Univ, Sch Med, Dept Dermatol, Boston, MA 02115 USA.
EM harvardskinstudies@partners.org
RI Kimball, Alexandra/M-6347-2019
OI Kimball, Alexandra/0000-0001-9405-0479
FU Alpha Omega Alpha Carolyn L. Kuckein Student Research Fellowship
FX This study was supported in part by an Alpha Omega Alpha Carolyn L.
   Kuckein Student Research Fellowship. The funder was not involved in any
   aspect of the study.
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NR 25
TC 13
Z9 14
U1 0
U2 10
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0926-9959
EI 1468-3083
J9 J EUR ACAD DERMATOL
JI J. Eur. Acad. Dermatol. Venereol.
PD FEB
PY 2014
VL 28
IS 2
BP 216
EP 221
DI 10.1111/jdv.12089
PG 6
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology
GA 287HI
UT WOS:000329532300009
PM 23347229
DA 2025-06-11
ER

PT J
AU Adela, R
   Banerjee, SK
AF Adela, Ramu
   Banerjee, Sanjay K.
TI GDF-15 as a Target and Biomarker for Diabetes and Cardiovascular
   Diseases: A Translational Prospective
SO JOURNAL OF DIABETES RESEARCH
LA English
DT Review
ID GROWTH-DIFFERENTIATION FACTOR-15; MACROPHAGE INHIBITORY CYTOKINE-1;
   MANGANESE SUPEROXIDE-DISMUTASE; BETA SUPERFAMILY MEMBER;
   LOW-DENSITY-LIPOPROTEIN; LEFT-VENTRICULAR MASS; TGF-BETA;
   GENE-EXPRESSION; MYOCARDIAL-INFARCTION; RISK STRATIFICATION
AB Growth differentiation factor-15 (GDF-15) is a stress responsive cytokine. It is highly expressed in cardiomyocytes, adipocytes, macrophages, endothelial cells, and vascular smooth muscle cells in normal and pathological condition. GDF-15 increases during tissue injury and inflammatory states and is associated with cardiometabolic risk. Increased GDF-15 levels are associated with cardiovascular diseases such as hypertrophy, heart failure, atherosclerosis, endothelial dysfunction, obesity, insulin resistance, diabetes, and chronic kidney diseases in diabetes. IncreasedGDF-15 level is linked with the progression and prognosis of the disease condition. Age, smoking, and environmental factors are other risk factors that may increase GDF-15 level. Most of the scientific studies reported that GDF-15 plays a protective role in different tissues. However, few reports show that the deficiency of GDF-15 is beneficial against vascular injury and inflammation. GDF-15 protects heart, adipose tissue, and endothelial cells by inhibiting JNK (c-Jun N-terminal kinase), Bad (Bcl-2-associated death promoter), and EGFR (epidermal growth factor receptor) and activating Smad, eNOS, PI3K, and AKT signaling pathways. The present review describes the different animal and clinical studies and patent updates of GDF-15 in diabetes and cardiovascular diseases. It is a challenge for the scientific community to use GDF-15 information for patient monitoring, clinical decision-making, and replacement of current treatment strategies for diabetic and cardiovascular diseases.
C1 [Adela, Ramu; Banerjee, Sanjay K.] THSTI, Drug Discovery Res Ctr, Faridabad 122014, Haryana, India.
C3 Department of Biotechnology (DBT) India; Translational Health Science &
   Technology Institute (THSTI)
RP Banerjee, SK (corresponding author), THSTI, Drug Discovery Res Ctr, Faridabad 122014, Haryana, India.
EM skbanerjee@thsti.res.in
RI Adela, Ramu/HKO-9169-2023
OI Banerjee, Sanjay k/0000-0002-0044-0984; Adela, Ramu/0000-0003-0909-2557;
   Banerjee, Sanjay/0000-0002-0008-0480
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NR 117
TC 357
Z9 379
U1 5
U2 60
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2314-6745
EI 2314-6753
J9 J DIABETES RES
JI J. Diabetes Res.
PY 2015
VL 2015
AR 490842
DI 10.1155/2015/490842
PG 14
WC Endocrinology & Metabolism; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Research & Experimental Medicine
GA CO5WV
UT WOS:000359230100001
PM 26273671
OA Green Published, Green Submitted, gold
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Pagidipati, NJ
   Hemal, K
   Coles, A
   Mark, DB
   Dolor, RJ
   Pellikka, PA
   Hoffmann, U
   Litwin, SE
   Udelson, J
   Daubert, MA
   Shah, SH
   Martinez, B
   Lee, KL
   Douglas, PS
AF Pagidipati, Neha J.
   Hemal, Kshipra
   Coles, Adrian
   Mark, Daniel B.
   Dolor, Rowena J.
   Pellikka, Patricia A.
   Hoffmann, Udo
   Litwin, Sheldon E.
   Udelson, James
   Daubert, Melissa A.
   Shah, Svati H.
   Martinez, Beth
   Lee, Kerry L.
   Douglas, Pamela S.
TI Sex Differences in Functional and CT Angiography Testing in Patients
   With Suspected Coronary Artery Disease
SO JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
LA English
DT Article
DE coronary artery disease; imaging; noninvasive testing; prognosis; risk
   stratification
ID SYNDROME EVALUATION WISE; CARDIAC SYNDROME-X; COMPUTED-TOMOGRAPHY;
   CLINICAL CHARACTERISTICS; GENDER-DIFFERENCES; PROGNOSTIC VALUE;
   CHEST-PAIN; FOLLOW-UP; HEART; WOMEN
AB BACKGROUND Although risk stratification is an important goal of cardiac noninvasive tests (NITs), few contemporary data exist on the prognostic value of different NITs according to patient sex.
   OBJECTIVES The goal of this study was to compare the results and prognostic information derived from anatomic versus stress testing in stable men and women with suspected coronary artery disease.
   METHODS In 8,966 patients tested at randomization (4,500 to computed tomography angiography [CTA], 52% female; 4,466 to stress testing, 53% female), we assessed the relationship between sex and NIT results and between sex and a composite of death, myocardial infarction, or unstable angina hospitalization.
   RESULTS In women, a positive CTA (>= 70% stenosis) was less likely than a positive stress test result (8% vs. 12%; adjusted odds ratio: 0.67). Compared with negative test results, a positive CTA was more strongly associated with subsequent clinical events than a positive stress test result (CTA-adjusted hazard ratio of 5.86 vs. stress-adjusted hazard ratio of 2.27; adjusted p = 0.028). Men were more likely to have a positive CTA than a positive stress test result (16% vs. 14%; adjusted odds ratio: 1.23). Compared with negative test results, a positive CTA was less strongly associated with subsequent clinical events than a positive stress test result in men, although this difference was not statistically significant (adjusted p = 0.168). Negative CTA and stress test results were equally likely to predict an event in both sexes. A significant interaction between sex, NIT type, and test result (p = 0.01) suggests that sex and NIT type jointly influence the relationship between test result and clinical events.
   CONCLUSIONS The prognostic value of an NIT result varies according to test type and patient sex. Women seem to derive more prognostic information from a CTA, whereas men tend to derive similar prognostic value from both test types. (C) 2016 by the American College of Cardiology Foundation.
C1 [Pagidipati, Neha J.; Hemal, Kshipra; Coles, Adrian; Mark, Daniel B.; Dolor, Rowena J.; Daubert, Melissa A.; Shah, Svati H.; Martinez, Beth; Lee, Kerry L.; Douglas, Pamela S.] Duke Univ, Sch Med, Duke Clin Res Inst, POB 17969, Durham, NC 27715 USA.
   [Dolor, Rowena J.; Shah, Svati H.] Duke Univ, Sch Med, Dept Med, Durham, NC 27715 USA.
   [Pellikka, Patricia A.] Mayo Clin, Rochester, MN USA.
   [Hoffmann, Udo] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Boston, MA USA.
   [Litwin, Sheldon E.] Med Univ S Carolina, Dept Med, Charleston, SC 29425 USA.
   [Udelson, James] Tufts Univ, Sch Med, Tufts Med Ctr, Boston, MA 02111 USA.
C3 Duke University; Duke University; Mayo Clinic; Harvard University;
   Harvard University Medical Affiliates; Massachusetts General Hospital;
   Harvard Medical School; Medical University of South Carolina; Tufts
   University; Tufts Medical Center
RP Pagidipati, NJ (corresponding author), Duke Univ, Sch Med, Duke Clin Res Inst, POB 17969, Durham, NC 27715 USA.
EM neha.pagidipati@dm.duke.edu
RI Pellikka, Patricia/N-5387-2014; Douglas, Pamela/B-3264-2013
OI Douglas, Pamela/0000-0001-9876-4049; Pellikka,
   Patricia/0000-0001-6800-3521; Coles, Adrian/0000-0001-5642-5962; Dolor,
   Rowena/0000-0001-7317-9468
FU National Heart, Lung, and Blood Institute [R01HL098237, R01HL098236,
   R01HL98305, R01HL098235]; Medtronic; CardioDx; St. Jude Medical; Eli
   Lilly; Bristol-Myers Squibb; Gilead Sciences; AGA Medical; Merck; Oxygen
   Biotherapeutics; AstraZeneca; Siemens Healthcare; HeartFlow
FX From the <SUP>a</SUP>Duke Clinical Research Institute, Duke University
   School of Medicine, Durham, North Carolina; <SUP>b</SUP>Department of
   Medicine, Duke University School of Medicine, Durham, North Carolina;
   <SUP>c</SUP>Mayo Clinic, Rochester, Minnesota; <SUP>d</SUP>Massachusetts
   General Hospital, Harvard Medical School, Boston, Massachusetts;
   <SUP>e</SUP>Department of Medicine, Medical University of South
   Carolina, Charleston, South Carolina; and the <SUP>f</SUP>Tufts Medical
   Center, Tufts University School of Medicine, Boston, Massachusetts. This
   project was supported by grants from the National Heart, Lung, and Blood
   Institute (R01HL098237, R01HL098236, R01HL98305, and R01HL098235). This
   paper does not necessarily represent the official views of the National
   Heart, Lung, and Blood Institute. Dr. Mark has received personal fees
   from Medtronic, CardioDx, and St. Jude Medical; and grant support from
   Eli Lilly, Bristol-Myers Squibb, Gilead Sciences, AGA Medical, Merck,
   Oxygen Biotherapeutics, and AstraZeneca. Dr. Hoffmann has received grant
   support from Siemens Healthcare and HeartFlow. Dr. Douglas has received
   grant support from HeartFlow; and serves on a Data and Safety Monitoring
   Board for GE Healthcare. All other authors have reported that they have
   no relationships relevant to the contents of this paper to disclose.
CR Arruda-Olson AM, 2002, J AM COLL CARDIOL, V39, P625, DOI 10.1016/S0735-1097(01)01801-0
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NR 21
TC 67
Z9 69
U1 0
U2 6
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0735-1097
EI 1558-3597
J9 J AM COLL CARDIOL
JI J. Am. Coll. Cardiol.
PD JUN 7
PY 2016
VL 67
IS 22
BP 2607
EP 2616
DI 10.1016/j.jacc.2016.03.523
PG 10
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA DN7QF
UT WOS:000377271300007
PM 27058908
OA Bronze, Green Accepted
DA 2025-06-11
ER

PT J
AU Keathley, J
   de Toro-Martin, J
   Kearney, M
   Garneau, V
   Pilon, G
   Couture, P
   Marette, A
   Vohl, MC
   Couillard, C
AF Keathley, Justine
   de Toro-Martin, Juan
   Kearney, Michele
   Garneau, Veronique
   Pilon, Genevieve
   Couture, Patrick
   Marette, Andre
   Vohl, Marie-Claude
   Couillard, Charles
TI Gene expression signatures and cardiometabolic outcomes following 8-week
   mango consumption in individuals with overweight/obesity
SO FRONTIERS IN NUTRITION
LA English
DT Article
DE transcriptomics; cardiometabolic risk factors; precision nutrition;
   mango; Mangifera
ID PACKAGE; PLASMA
AB Background: Little is known about the impact of mango consumption on metabolic pathways assessed by changes in gene expression. Methods: In this single-arm clinical trial, cardiometabolic outcomes and gene expression levels in whole blood samples from 26 men and women were examined at baseline and after 8 weeks of mango consumption and differential gene expression changes were determined. Based on changes in gene expression profiles, partial least squares discriminant analysis followed by hierarchical clustering were used to classify participants into subgroups of response and differences in gene expression changes and in cardiometabolic clinical outcomes following the intervention were tested. Results: Two subgroups of participants were separated based on the resemblance of gene expression profiles in response to the intervention and as responders (n = 8) and non-responders (n = 18). A total of 280 transcripts were significantly up-regulated and 603 transcripts down-regulated following the intervention in responders, as compared to non-responders. Several metabolic pathways, mainly related to oxygen and carbon dioxide transport as well as oxidative stress, were found to be significantly enriched with differentially expressed genes. In addition, significantly beneficial changes in hip and waist circumference, c-reactive protein, HOMA-IR and QUICKI indices were observed in responders vs. non-responders, following the intervention. Conclusion: The impact of mango consumption on cardiometabolic health appears to largely rely on interindividual variability. The novel transcriptomic-based clustering analysis used herein can provide insights for future research focused on unveiling the origins of heterogeneous responses to dietary interventions.
C1 [Keathley, Justine; de Toro-Martin, Juan; Kearney, Michele; Garneau, Veronique; Pilon, Genevieve; Couture, Patrick; Marette, Andre; Vohl, Marie-Claude; Couillard, Charles] Univ Laval, Inst Sur Nutr & Aliments Fonctionnels INAF, Ctr Nutr Sante & Soc NUTRISS, Quebec City, PQ, Canada.
   [Keathley, Justine; de Toro-Martin, Juan; Kearney, Michele; Garneau, Veronique; Vohl, Marie-Claude; Couillard, Charles] Univ Laval, Sch Nutr, Quebec City, PQ, Canada.
   [Pilon, Genevieve; Marette, Andre] Quebec Heart & Lung Inst IUCPQ, Res Ctr, Quebec City, PQ, Canada.
   [Couture, Patrick] CHU Quebec, Endocrinol & Nephrol Unit, Res Ctr, Quebec City, PQ, Canada.
C3 Laval University; Laval University; Quebec Heart & Lung Institute; Laval
   University; Laval University Hospital
RP Couillard, C (corresponding author), Univ Laval, Inst Sur Nutr & Aliments Fonctionnels INAF, Ctr Nutr Sante & Soc NUTRISS, Quebec City, PQ, Canada.; Couillard, C (corresponding author), Univ Laval, Sch Nutr, Quebec City, PQ, Canada.
EM charles.couillard@fsaa.ulaval.ca
RI Marette, Andre/E-9342-2013; Vohl, Marie-Claude/AAQ-1378-2021
FU National Mango Board; Canadian Institutes of Health Research, Centre
   Nutrition, sante et societe (NUTRISS),; Institut sur la nutrition et les
   aliments fonctionnels (INAF)
FX This project was supported by a grant by the National Mango Board. The
   National Mango Board was not involved in the study hypothesis/design,
   execution, analysis or interpretation. JK was supported through
   postdoctoral fellowships from the Canadian Institutes of Health
   Research, Centre Nutrition, sante et societe (NUTRISS), and the Institut
   sur la nutrition et les aliments fonctionnels (INAF). AM holds a Pfizer
   research Chair in the pathogenesis of insulin resistance and
   cardiovascular diseases. M-CV was the Canada Research Chair in Genomics
   Applied to Nutrition and Metabolic Health.
CR Awodele Olufunsho, 2015, Interdiscip Toxicol, V8, P175, DOI 10.1515/intox-2015-0027
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NR 29
TC 3
Z9 3
U1 0
U2 0
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD AUG 11
PY 2022
VL 9
AR 918844
DI 10.3389/fnut.2022.918844
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 3Z4PA
UT WOS:000844397700001
PM 36034894
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Gyllenhammar, T
   Carlsson, M
   Jögi, J
   Arheden, H
   Engblom, H
AF Gyllenhammar, Tom
   Carlsson, Marcus
   Jogi, Jonas
   Arheden, Hakan
   Engblom, Henrik
TI Myocardial perfusion by CMR coronary sinus flow shows sex differences
   and lowered perfusion at stress in patients with suspected microvascular
   angina
SO CLINICAL PHYSIOLOGY AND FUNCTIONAL IMAGING
LA English
DT Article
DE cardiac syndrome X; CMR; coronary sinus flow; global myocardial
   perfusion; INOCA; microvascular angina
ID CARDIAC MAGNETIC-RESONANCE; ARTERY-DISEASE; CLINICAL CHARACTERISTICS;
   WORKING GROUP; CHEST-PAIN; BLOOD-FLOW; FOLLOW-UP; ISCHEMIA; RESERVE;
   DYSFUNCTION
AB Background Patients with chest pain may have normal coronary arteries and suffer from microvascular angina (MVA). The aim of this study was to determine if patients with suspected MVA have lower global myocardial perfusion (global MP) during adenosine stress compared with healthy controls and coronary artery disease (CAD) patients and to determine if there are sex differences in global MP. Methods Twenty-three patients with suspected MVA (66 +/- 11 years), 19 CAD patients (69 +/- 5 years) with stress-induced ischaemia and 24 healthy controls (61 +/- 10 years) underwent cardiac magnetic resonance (CMR) including coronary sinus flow measurements and first-pass perfusion at rest and during adenosine stress. Global MP was quantified as coronary sinus flow normalized to left ventricular mass. Results Global perfusion was lower during stress in patients with suspected MVA (2.9 +/- 1.0 ml/min/g) compared with healthy volunteers (3.7 +/- 1.1 ml/min/g, p = 0.018), but higher compared with CAD patients (2.0 +/- 0.9 ml/min/g, p = 0.019). Female controls had higher global MP than male controls both at rest (1.0 +/- 0.3 vs. 0.7 +/- 0.2 ml/min/g, p = 0.003) and during stress (4.4 +/- 1.0 vs. 3.1 +/- 0.6 ml/min/g, p = 0.001). Furthermore, females with suspected MVA showed higher global MP than males with suspected MVA (3.3 +/- 1.0 vs. 2.4 +/- 0.7, p = 0.04). Conclusions Patients with suspected MVA have lower global MP at stress than healthy volunteers but higher than patients with CAD. Furthermore, there seems to be a sex difference in global MP at stress both in healthy volunteers and in patients with suspected MVA, with higher global MP in females, which implies a need for sex-specific normal limits when assessing quantitative MP.
C1 Lund Univ, Dept Clin Physiol, Lund, Sweden.
   [Engblom, Henrik] Skane Univ Hosp, SE-22185 Lund, Sweden.
C3 Lund University; Lund University; Skane University Hospital
RP Engblom, H (corresponding author), Skane Univ Hosp, SE-22185 Lund, Sweden.; Engblom, H (corresponding author), Lund Univ, Dept Clin Physiol & Nucl Med, SE-22185 Lund, Sweden.
EM henrik.engblom@med.lu.se
RI Carlsson, Marcus/AAR-4318-2021; Jögi, Jonas/M-5389-2014; Carlsson,
   Marcus/B-1905-2013
OI Gyllenhammar, Tom/0000-0002-5063-3514; Jogi, Jonas/0000-0002-5299-3628;
   Carlsson, Marcus/0000-0002-9480-5250
FU Swedish Heart and Lund Foundation; Region of Scania; Lund University
   Medical Faculty
FX Swedish Heart and Lund Foundation; Region of Scania; Lund University
   Medical Faculty
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NR 54
TC 6
Z9 6
U1 0
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1475-0961
EI 1475-097X
J9 CLIN PHYSIOL FUNCT I
JI Clin. Physiol. Funct. Imaging
PD MAY
PY 2022
VL 42
IS 3
BP 208
EP 219
DI 10.1111/cpf.12750
EA MAR 2022
PG 12
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA 0M3FI
UT WOS:000773654200001
PM 35279944
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Chovanec, M
   Lauritsen, J
   Bandak, M
   Oing, C
   Kier, GG
   Kreiberg, M
   Rosenvilde, J
   Wagner, T
   Bokemeyer, C
   Daugaard, G
AF Chovanec, Michal
   Lauritsen, Jakob
   Bandak, Mikkel
   Oing, Christoph
   Kier, Gry Gundgaard
   Kreiberg, Michael
   Rosenvilde, Josephine
   Wagner, Thomas
   Bokemeyer, Carsten
   Daugaard, Gedske
TI Late adverse effects and quality of life in survivors of testicular germ
   cell tumour
SO NATURE REVIEWS UROLOGY
LA English
DT Review
ID LONG-TERM SURVIVORS; CISPLATIN-BASED CHEMOTHERAPY; STAGE-I SEMINOMA;
   CARDIOVASCULAR-DISEASE MORTALITY; LYMPH-NODE DISSECTION; BLEOMYCIN
   HYDROLASE GENE; RESEARCH-COUNCIL TRIAL; CANCER SURVIVORS; METABOLIC
   SYNDROME; RISK-FACTORS
AB Currently, similar to 95% of patients with testicular germ cell tumour (TGCT) are cured, resulting in an increasing number of TGCT survivors. Although cured, these men face potential late adverse effects and reduced quality of life. Survivors face a twofold increased risk of second malignant neoplasms after chemotherapy and radiotherapy, with evidence of dose-dependent associations. For survivors managed with surveillance or treated with radiotherapy, the risk of cardiovascular disease (CVD) is comparable to the risk in the general population, whereas treatment with chemotherapy increases the risk of life-threatening CVD, especially during treatment and after 10 years of follow-up. Other adverse effects are organ-related toxicities such as neuropathy and ototoxicity. Pulmonary and renal impairment in patients with TGCT treated with chemotherapy is limited. Survivors of TGCT might experience psychosocial distress including anxiety disorders, fear of cancer recurrence and TGCT-specific issues, such as sexual dysfunction. Late adverse effects can be avoided in most patients with stage I disease if followed on a surveillance programme. However, patients with disseminated disease can experience toxicities associated with radiotherapy and chemotherapy, and/or adverse effects related to surgery for residual disease. The severity of adverse effects increases with dose of both chemotherapy and radiotherapy. This Review discusses the most recent data concerning the late adverse effects of today's standard treatments for TGCT.
C1 [Chovanec, Michal] Comenius Univ, Natl Canc Inst, Dept Oncol 2, Bratislava, Slovakia.
   [Lauritsen, Jakob; Bandak, Mikkel; Kier, Gry Gundgaard; Kreiberg, Michael; Rosenvilde, Josephine; Wagner, Thomas; Daugaard, Gedske] Copenhagen Univ Hosp, Dept Oncol, Rigshosp, Copenhagen, Denmark.
   [Oing, Christoph; Bokemeyer, Carsten] Univ Med Ctr Hamburg Eppendorf, Div Pneumol, Dept Oncol Hematol & Bone Marrow Transplantat, Hamburg, Germany.
C3 National Institute of Oncology (NOU); Comenius University Bratislava;
   University of Copenhagen; Copenhagen University Hospital;
   Rigshospitalet; University of Hamburg; University Medical Center
   Hamburg-Eppendorf
RP Daugaard, G (corresponding author), Copenhagen Univ Hosp, Dept Oncol, Rigshosp, Copenhagen, Denmark.
EM Kirsten.gedske.daugaard@regionh.dk
RI Daugaard, Gedske/GYD-8913-2022; Lauritsen, Jakob/AAG-1987-2019; Oing,
   Christoph/Y-4937-2019
OI Wagner, Thomas/0000-0002-0256-0074; Chovanec,
   Michal/0000-0002-5653-2909; Daugaard, Gedske/0000-0002-9618-9180;
   Lauritsen, Jakob/0000-0002-9985-174X; Oing,
   Christoph/0000-0001-5578-3418; Rosenvilde,
   Josephine/0000-0002-7293-2339; Kreiberg, Michael/0000-0001-5611-5163
FU Slovak Research and Development Agency [APVV-15-0086, APVV-19-0411]
FX The work of M.C. is supported by the Slovak Research and Development
   Agency under contract no. APVV-15-0086 and APVV-19-0411.
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PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 1759-4812
EI 1759-4820
J9 NAT REV UROL
JI Nat. Rev. Urol.
PD APR
PY 2021
VL 18
IS 4
BP 227
EP 245
DI 10.1038/s41585-021-00440-w
EA MAR 2021
PG 19
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Urology & Nephrology
GA RK2QV
UT WOS:000626379200001
PM 33686290
DA 2025-06-11
ER

PT J
AU Di Monaco, A
   Lanza, GA
   Bruno, I
   Careri, G
   Pinnacchio, G
   Tarzia, P
   Battipaglia, I
   Giordano, A
   Crea, F
AF Di Monaco, Antonio
   Lanza, Gaetano Antonio
   Bruno, Isabella
   Careri, Giulia
   Pinnacchio, Gaetano
   Tarzia, Pierpaolo
   Battipaglia, Irma
   Giordano, Alessandro
   Crea, Filippo
TI Usefulness of Impairment of Cardiac Adrenergic Nerve Function to Predict
   Outcome in Patients With Cardiac Syndrome X
SO AMERICAN JOURNAL OF CARDIOLOGY
LA English
DT Article
ID NORMAL CORONARY ANGIOGRAMS; SPINAL-CORD STIMULATION; TERM-FOLLOW-UP;
   CHEST-PAIN; MICROVASCULAR DYSFUNCTION; CLINICAL PRESENTATION; PROGNOSTIC
   VALUE; ANGINA-PECTORIS; SENSITIVITY; MECHANISMS
AB Patients with cardiac syndrome X (CSX) have an excellent long-term prognosis, but a significant number show worsening angina over time. Previous studies have found a significant impairment of cardiac uptake of iodine-123-meta-iodobenzylguanidine (MIBG) on myocardial scintigraphy, indicating abnormal function of cardiac adrenergic nerve fibers. The aim of this study was to assess whether cardiac MIBG results can predict symptomatic outcome in patients with CSX. Cardiac MIBG scintigraphy was performed in 40 patients with CSX (mean age 58 +/- 5 years, 14 men). Cardiac MIBG uptake was measured by the heart/mediastinum uptake ratio and a single photon-emission computed tomographic regional uptake score (higher values reflected lower uptake). Clinical findings, exercise stress test parameters, sestamibi stress myocardial scintigraphy, and C-reactive protein serum levels were also assessed. At an average follow-up of 79 months (range 36 to 144), no patient had died or developed acute myocardial infarction. Cardiac MIBG defect score was significantly lower in patients with worsening versus those without worsening of angina status (13 +/- 7 vs 38 +/- 28, p = 0.001), in those with versus those without hospital readmission because of recurrent chest pain (15 +/- 9 vs 35 +/- 29, p = 0.01), and in those who underwent versus those who did not undergo repeat coronary angiography (11 +/- 7 vs 36 +/- 27, p = 0.001). Significant correlations were found between quality of life (as assessed by the EuroQoL scale) and heart/mediastinum ratio (r = 0.48, p = 0.002) and cardiac MIBG uptake score (r = -0.69, p <0.001). No other clinical or laboratory variable showed a significant association with clinical end points. In conclusion, in patients with CSX, abnormal function of cardiac adrenergic nerve fibers, as assessed by an impairment of cardiac MIBG uptake, identifies those with worse symptomatic clinical outcomes. (c) 2010 Elsevier Inc. All rights reserved. (Am J Cardiol 2010;106:1813-1818)
C1 [Di Monaco, Antonio; Lanza, Gaetano Antonio; Careri, Giulia; Pinnacchio, Gaetano; Tarzia, Pierpaolo; Battipaglia, Irma; Crea, Filippo] Univ Cattolica Sacro Cuore, Ist Cardiol, Rome, Italy.
   [Bruno, Isabella; Giordano, Alessandro] Univ Cattolica Sacro Cuore, Ist Med Nucl, Rome, Italy.
C3 Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli;
   Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli
RP Lanza, GA (corresponding author), Univ Cattolica Sacro Cuore, Ist Cardiol, Rome, Italy.
EM g.a.lanza@rm.unicatt.it
RI Giordano, Alessandro/AAW-9921-2021; Crea, Filippo/AAC-9754-2022;
   Battipaglia, Irma/AAA-8589-2020; Tarzia, Pierpaolo/AAC-1593-2019; Lanza,
   Gaetano/AAC-2660-2019; Di monaco, Antonio/AAR-8825-2021
OI Pinnacchio, Gaetano/0000-0001-6642-1682; Giordano,
   Alessandro/0000-0002-6978-0880; Di monaco, Antonio/0000-0002-1297-2056
CR Baron R, 1996, PAIN, V67, P317, DOI 10.1016/0304-3959(96)03136-3
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NR 29
TC 7
Z9 7
U1 0
U2 2
PU EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
PI BRIDGEWATER
PA 685 ROUTE 202-206 STE 3, BRIDGEWATER, NJ 08807 USA
SN 0002-9149
EI 1879-1913
J9 AM J CARDIOL
JI Am. J. Cardiol.
PD DEC 15
PY 2010
VL 106
IS 12
BP 1813
EP 1818
DI 10.1016/j.amjcard.2010.07.052
PG 6
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 700JN
UT WOS:000285735000024
PM 21126626
DA 2025-06-11
ER

PT J
AU Roh, E
   Chung, HS
   Lee, JS
   Kim, JA
   Lee, YB
   Hong, SH
   Kim, NH
   Yoo, HJ
   Seo, JA
   Kim, SG
   Kim, NH
   Baik, SH
   Choi, KM
AF Roh, Eun
   Chung, Hye Soo
   Lee, Ji Sung
   Kim, Jung A.
   Lee, You-Bin
   Hong, So-hyeon
   Kim, Nam Hoon
   Yoo, Hye Jin
   Seo, Ji A.
   Kim, Sin Gon
   Kim, Nan Hee
   Baik, Sei Hyun
   Choi, Kyung Mook
TI Total cholesterol variability and risk of atrial fibrillation: A
   nationwide population-based cohort study
SO PLOS ONE
LA English
DT Article
ID OXIDATIVE STRESS; PREVALENCE; GLUCOSE; STROKE; EPIDEMIOLOGY; MANAGEMENT;
   MORTALITY; OUTCOMES; DISEASE
AB Background
   Long-term variability of cardiometabolic risk factors have been suggested as the risk factors for cardiovascular disease and mortality. However, the effect of long-term variability of total cholesterol (TC) on incident atrial fibrillation (AF) has not been examined.
   Methods and findings
   We explored whether visit-to-visit TC variability are associated with the risk of incident AF in 160,165 Korean adults, using the population-based Korean National Health Insurance Service-Health Screening Cohort (NHIS-HEALS) database, over a median duration of 8.4 years. TC variability was measured as coefficients of variance (TC-CV), standard deviation (TC-SD), and variability independent of the mean (TC-VIM). Kaplan-Meier analysis demonstrated a decreased disease-free probability in the highest quartile group of TC variability compared to that in the other groups. In the multivariate Cox proportional hazard analysis, the risk of AF increased significantly in the highest quartile group of TC variability. After multivariate adjustment for confounding variables including mean TC levels, the hazard ratio for incident AF was 1.15 (95% confidence interval 1.05-1.25; P = 0.0035) when comparing the highest with the lowest TC variability quartile (TC-CV). These relationships were consistent with TC variability defined using TC-SD or TC-VIM. Subgroup analyses, including age, sex, body mass index, and cardiometabolic disorders, showed similar results.
   Conclusions
   The present study is the first to demonstrate that high TC variability was associated with an increased risk of AF.
C1 [Roh, Eun; Kim, Jung A.; Lee, You-Bin; Hong, So-hyeon; Kim, Nam Hoon; Yoo, Hye Jin; Seo, Ji A.; Kim, Sin Gon; Kim, Nan Hee; Baik, Sei Hyun; Choi, Kyung Mook] Korea Univ, Dept Internal Med, Div Endocrinol & Metab, Coll Med, Seoul, South Korea.
   [Chung, Hye Soo] Hallym Univ, Dept Internal Med, Div Endocrinol & Metab, Coll Med, Seoul, South Korea.
   [Lee, Ji Sung] Univ Ulsan, Clin Res Ctr, Asan Med Ctr, Coll Med, Seoul, South Korea.
C3 Korea University; Korea University Medicine (KU Medicine); Hallym
   University; Samsung; University of Ulsan; Asan Medical Center
RP Choi, KM (corresponding author), Korea Univ, Dept Internal Med, Div Endocrinol & Metab, Coll Med, Seoul, South Korea.
EM medica7@gmail.com
RI Kim, Sin Gon/KQU-7757-2024; Chung, Hye/AAG-8591-2020; Choi,
   Kyung/C-4195-2018; Kim, Nan/T-8627-2019; SEO, JI/AAU-7968-2020; Kim, Nam
   Hoon/HNS-5794-2023; Moon, Kyung/J-5465-2012; Kim, JungAe/JDC-5533-2023
OI Lee, You-Bin/0000-0003-4058-1738; Kim, Jung A/0000-0002-6595-6551; Kim,
   Sin Gon/0000-0002-7430-3675; Chung, Hye Soo/0000-0003-0819-5167; Kim,
   Nan Hee/0000-0003-4378-520X; Choi, Kyung Mook/0000-0001-6175-0225; Kim,
   Nam Hoon/0000-0002-9926-1344
FU Korea University Research Fund [K1809301, Q1625561]
FX This work was supported by the Korea University Research Fund (K1809301,
   Q1625561). All investigators are independent from funders. The funders
   had no role in study design, data collection and analysis, decision to
   publish, or preparation of the manuscript. The funders had no role in
   study design, data collection and analysis, decision to publish, or
   preparation of the manuscript.
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NR 39
TC 19
Z9 20
U1 3
U2 5
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD APR 24
PY 2019
VL 14
IS 4
AR e0215687
DI 10.1371/journal.pone.0215687
PG 13
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA HU6FU
UT WOS:000465375400056
PM 31017966
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Guzzardi, MA
   Iozzo, P
   Salonen, M
   Kajantie, E
   Eriksson, JG
AF Guzzardi, Maria Angela
   Iozzo, Patricia
   Salonen, Minna
   Kajantie, Eero
   Eriksson, Johan G.
TI Rate of telomere shortening and metabolic and cardiovascular risk
   factors: A longitudinal study in the 1934-44 Helsinki Birth Cohort Study
SO ANNALS OF MEDICINE
LA English
DT Article
DE Adiposity; ageing; blood pressure; dyslipidaemia; telomere shortening
ID BODY-MASS INDEX; OXIDATIVE STRESS; INSULIN-RESISTANCE; LENGTH; OBESITY;
   DISEASE; MEN; PREVENTION; EVENTS; ADULTS
AB Introduction. Leucocyte telomere length (LTL) is associated with age-related health outcomes, but only few longitudinal studies have assessed changes in LTL in an ageing population.
   Methods. A total of 1,082 subjects from the Helsinki Birth Cohort Study (born 1934-1944), undergoing two clinical visits similar to 10 years apart, were studied. Relative LTL was measured twice by quantitative real-time PCR. Simple and multiple regressions were used to study associations between cardiometabolic risk factors and LTL.
   Results. Telomere shortening was observed in 93.7%, and telomere elongation in 6.3% of the study participants. Telomere shortening was more rapid among males (-39.5% +/- 1.1% versus -35.5% +/- 1.0%, P < 0.01). In men a decrease in weight, waist circumference, BMI, and body fat percentage were all associated with telomere shortening during the follow-up (P < 0.05) independently of age and use of medication. Furthermore, higher body fat percentage and higher HDL-cholesterol level were associated with a slower rate of shortening in LTL (P < 0.05). Lower blood pressure levels were also associated with slower rate of telomere shortening in men (P < 0.05). No similar associations were observed among women.
   Discussion. A decrease in adiposity was associated with telomere shortening, and higher body fat percentage and HDL-cholesterol were associated with a slower rate of shortening in telomere length in men.
C1 [Guzzardi, Maria Angela; Iozzo, Patricia] CNR, Inst Clin Physiol, I-56100 Pisa, Italy.
   [Salonen, Minna; Kajantie, Eero; Eriksson, Johan G.] Natl Inst Hlth & Welf, Dept Chron Dis Prevent, Helsinki, Finland.
   [Salonen, Minna; Eriksson, Johan G.] Folkhalsan Res Ctr, Helsinki, Finland.
   [Kajantie, Eero] Univ Helsinki, Cent Hosp, Hosp Children & Adolescents, Helsinki, Finland.
   [Kajantie, Eero] Univ Helsinki, Helsinki, Finland.
   [Eriksson, Johan G.] Univ Helsinki, Dept Gen Practice & Primary Hlth Care, Helsinki, Finland.
   [Eriksson, Johan G.] Helsinki Univ Hosp, Helsinki, Finland.
C3 Consiglio Nazionale delle Ricerche (CNR); Istituto di Fisiologia Clinica
   (IFC-CNR); Finland National Institute for Health & Welfare; Folkhalsan
   Research Center; University of Helsinki; Helsinki University Central
   Hospital; University of Helsinki; University of Helsinki; University of
   Helsinki; Helsinki University Central Hospital
RP Eriksson, JG (corresponding author), Univ Helsinki, POB 20, FIN-00014 Helsinki, Finland.
EM johan.eriksson@helsinki.fi
RI Gibbs, J. Raphael/A-3984-2010; Iozzo, Patricia/O-2893-2015; GUZZARDI,
   MARIAANGELA/K-1389-2016
OI Iozzo, Patricia/0000-0001-6443-7074; GUZZARDI,
   MARIAANGELA/0000-0001-9574-5088; Eriksson, Johan/0000-0002-2516-2060
FU Finska Lakaresallskapet; Finnish Special Governmental Subsidy for Health
   Sciences; Academy of Finland; Samfundet Folkhalsan; Liv och Halsa; Signe
   and Ane Gyllenberg Foundation; EU FP7 (DORIAN) project [278603]
FX HBCS has been supported by grants from Finska Lakaresallskapet, the
   Finnish Special Governmental Subsidy for Health Sciences, Academy of
   Finland, Samfundet Folkhalsan, Liv och Halsa, the Signe and Ane
   Gyllenberg Foundation, and EU FP7 (DORIAN) project number 278603.
CR [Anonymous], GLOB BRIEF WORLD HLT
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NR 33
TC 23
Z9 24
U1 0
U2 8
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0785-3890
EI 1365-2060
J9 ANN MED
JI Ann. Med.
PY 2015
VL 47
IS 6
BP 499
EP 505
DI 10.3109/07853890.2015.1074718
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA CS6FK
UT WOS:000362173100009
PM 26339993
DA 2025-06-11
ER

PT J
AU Sicari, R
   Rigo, F
   Cortigiani, L
   Gherardi, S
   Galderisi, M
   Picano, E
AF Sicari, Rosa
   Rigo, Fausto
   Cortigiani, Lauro
   Gherardi, Sonia
   Galderisi, Mourizio
   Picano, Eugenio
TI Additive Prognostic Value of Coronary Flow Reserve in Patients With
   Chest Pain Syndrome and Normal or Near-Normal Coronary Arteries
SO AMERICAN JOURNAL OF CARDIOLOGY
LA English
DT Article
ID DIPYRIDAMOLE-ECHOCARDIOGRAPHY TEST; CARDIOVASCULAR MAGNETIC-RESONANCE;
   CARDIAC SYNDROME-X; MICROVASCULAR DYSFUNCTION; MYOCARDIAL-ISCHEMIA;
   WALL-MOTION; DOPPLER-ECHOCARDIOGRAPHY; STRESS ECHOCARDIOGRAPHY;
   COMPUTED-TOMOGRAPHY; VELOCITY RESERVE
AB In patients with angiographically normal coronary arteries and chest pain, pharmacologic stress echocardiography can identify a subgroup of patients with a less benign prognosis. Coronary flow reserve (CFR) in the left anterior descending artery (LAD) can currently be combined with wall motion analysis during vasodilator stress echocardiography. The aim of this study was to assess the prognostic value of CFR response in patients with normal coronary arteries and normal wall motion during stress. We selected 394 patients (171 men, 61 +/- 11 years of age) who underwent dipyridamole stress echocardiography (0.84 mg/kg over 6 minutes) with 2-dimensional echocardiography and CFR evaluation of the LAD by Doppler. All had angiographically nonsignificant (<50% quantitatively assessed) stenosis in any major vessel, normal left ventricular function (wall motion score index 1), and test negativity for conventional wall motion criteria. Images were independently read by a core laboratory for wall motion and a core laboratory for CFR. Mean CFR was 2.5 +/- 0.6 and 87 patients (22%) had an abnormal CFR <2. During a median follow-up of 51 months, 31 events occurred, namely 4 deaths and 27 nonfatal myocardial infarctions (3 ST-elevated myocardial infarctions and 24 non-ST-elevated myocardial infarctions). Kaplan-Meier survival estimates for hard events showed a better outcome for those patients with a normal CFR compared with those with an abnormal CFR (96% vs 55%, p = 0.001, at 48 months of follow-up). In conclusion, in patients with angiographically normal or near-normal coronary arteries and preserved at-rest regional and global left ventricular function at baseline and during stress, CFR adds incremental value to the prognostic stratification achieved with clinical and angiographic data. (C) 2009 Elsevier Inc. (Am J Cardiol 2009; 103:626-631)
C1 [Sicari, Rosa; Picano, Eugenio] CNR, Inst Clin Physiol, I-56100 Pisa, Italy.
   [Rigo, Fausto] Umberto I Hosp, Div Cardiol, Mestre Venice, Italy.
   [Cortigiani, Lauro] Campo Marte Hosp, Div Cardiol, Lucca, Italy.
   [Gherardi, Sonia] Cesena Hosp, Div Cardiol, Cesena, Italy.
   [Galderisi, Mourizio] Univ Naples Federico 2, Dept Clin & Expt Med, Naples, Italy.
C3 Consiglio Nazionale delle Ricerche (CNR); Istituto di Fisiologia Clinica
   (IFC-CNR); University of Naples Federico II
RP Sicari, R (corresponding author), CNR, Inst Clin Physiol, Via Savi 8, I-56100 Pisa, Italy.
EM rosas@ifc.cnr.it
RI Picano, E/G-2261-2014; Rigo, Fausto/ABG-9721-2021
OI Galderisi, Maurizio/0000-0003-0311-9069
FU CNR, Institute of Clinical Physiology, Pisa, Italy
FX Financial support for the present study was received from institutional
   funding by the CNR, Institute of Clinical Physiology, Pisa, Italy.
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NR 29
TC 145
Z9 150
U1 0
U2 2
PU EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
PI BRIDGEWATER
PA 685 ROUTE 202-206 STE 3, BRIDGEWATER, NJ 08807 USA
SN 0002-9149
J9 AM J CARDIOL
JI Am. J. Cardiol.
PD MAR 1
PY 2009
VL 103
IS 5
BP 626
EP 631
DI 10.1016/j.amjcard.2008.10.033
PG 6
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 416DV
UT WOS:000263986500010
PM 19231324
DA 2025-06-11
ER

PT J
AU López-Tinoco, C
   Roca, M
   García-Valero, A
   Murri, M
   Tinahones, FJ
   Segundo, C
   Bartha, JL
   Aguilar-Diosdado, M
AF Lopez-Tinoco, Cristina
   Roca, Mar
   Garcia-Valero, Amor
   Murri, Mora
   Tinahones, Francisco J.
   Segundo, Carmen
   Bartha, Jose L.
   Aguilar-Diosdado, Manuel
TI Oxidative stress and antioxidant status in patients with late-onset
   gestational diabetes mellitus
SO ACTA DIABETOLOGICA
LA English
DT Article
DE Gestational diabetes mellitus; Markers of oxidative stress; Pregnancy
ID CIRCULATING ADHESION MOLECULES; INSULIN-RESISTANCE; GLUCOSE-TOLERANCE;
   METABOLIC-SYNDROME; NITRIC-OXIDE; WOMEN; HYPERGLYCEMIA; PREGNANCY;
   COMPLICATIONS; ATHEROSCLEROSIS
AB The relationship between late-onset gestational diabetes mellitus [GDM] and oxidative stress is not well known, and the importance of the oxidant/antioxidant equilibrium in the clinical evolution and its complications require elucidation. The aim of the study was to evaluate the relationships between maternal levels of markers of oxidative stress in women with late-onset GDM that, potentially, may have considerable clinical implications in the pathogenesis and/or the evolution of GDM. Pregnant women (n = 78; 53 with GDM, 25 controls), between the 24th and 29th week of gestation, were enrolled. Both groups were analysed for demographic data, perinatal and obstetrics outcomes together with the levels of the marker's oxidative stress and antioxidant status. Control versus patient results in the univariate analysis were the following: pre-gestational body mass index [BMI] 23.31 +/- A 4.2 vs. 27.13 +/- A 4.6 kg/m(2) (P = 0.001); weeks at delivery 39.2 +/- A 3.05 vs. 38.9 +/- A 1.8 (P = 0.09); Caesarean delivery 12.5 vs. 43% (P = 0.004); macrosomia 4 vs. 9.4% (P = 0.6); lipoperoxides [LPO] 2.06 +/- A 1.00 vs. 3.14 +/- A 1.55 mu mol/mg (P = 0.001); catalase 3.23 +/- A 1.41 vs. 2.52 +/- A 1.3 nmol/min/ml (P = 0.03); superoxide dismutase [SOD] 0.11 +/- A 0.04 vs. 0.08 +/- A 0.01 U/ml (P = 0.0003); glutathione peroxidase [GPX] 0.03 +/- A 0.006 vs. 0.025 +/- A 0.006 nmol/min/ml (P = 0.01); glutathione reductase [GSH] 0.004 +/- A 0.002 vs. 0.004 +/- A 0.004 nmol/min/ml (P = 0.9)]; and glutathione transferase [GST] 0.0025 +/- A 0.0012 vs. 0.0027 +/- A 0.00017 nmol/min/ml (P = 0.7). Multivariate analysis showed catalase might have a protective effect against GDM development and LPO seems to be a risk factor for the disease. These data suggest an increase in oxidative stress and a decrease in antioxidative defence in women with late-onset GDM and, as such, may have considerable clinical implications in the pathogenesis and/or the course of the pregnancy in these patients.
C1 [Lopez-Tinoco, Cristina; Garcia-Valero, Amor; Segundo, Carmen; Aguilar-Diosdado, Manuel] Hosp Puerta del Mar, Dept Endocrinol, Cadiz 11009, Spain.
   [Bartha, Jose L.] Hosp Puerta del Mar, Dept Gynaecoloy, Cadiz 11009, Spain.
   [Roca, Mar; Murri, Mora; Tinahones, Francisco J.] Hosp Virgen de la Victoria, Dept Endocrinol, Malaga, Spain.
   [Aguilar-Diosdado, Manuel] Hosp Puerta del Mar, Serv Endocrinol & Nutr, Cadiz 11009, Spain.
C3 Universidad de Cadiz; Hospital Universitario Puerta del Mar; Universidad
   de Cadiz; Hospital Universitario Puerta del Mar; Universidad de Cadiz;
   Hospital Universitario Puerta del Mar
RP Aguilar-Diosdado, M (corresponding author), Hosp Puerta del Mar, Serv Endocrinol & Nutr, Av Ana de Viya 21, Cadiz 11009, Spain.
EM manuel.aguilar.sspa@juntadeandalucia.es
RI Roca, Mar/AAC-9718-2021; Bartha, Jose/G-5401-2010; Tinahones,
   Francisco/AAB-2882-2020; Lopez-Tinoco, Cristina/K-5420-2019; Aguilar
   Diosdado, Manuel/A-2549-2009; Segundo, Carmen/A-7841-2012
OI Aguilar Diosdado, Manuel/0000-0001-9657-5949; Tinahones, Francisco
   J/0000-0001-6871-4403; Segundo, Carmen/0000-0003-2884-0557; Murri,
   Mora/0000-0002-6482-192X
FU Andalusia Department of Health [CTS-368]
FX This study was financed, in part, by grants from the Andalusia
   Department of Health (CTS-368).
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NR 39
TC 68
Z9 75
U1 0
U2 24
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0940-5429
J9 ACTA DIABETOL
JI Acta Diabetol.
PD APR
PY 2013
VL 50
IS 2
BP 201
EP 208
DI 10.1007/s00592-011-0264-2
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 135LA
UT WOS:000318288400014
PM 21327985
DA 2025-06-11
ER

PT J
AU Miyokawa-Gorin, K
   Takahashi, K
   Handa, K
   Kitahara, A
   Sumitani, Y
   Katsuta, H
   Tanaka, T
   Nishida, S
   Yoshimoto, K
   Ohno, H
   Ishida, H
AF Miyokawa-Gorin, Kaoru
   Takahashi, Kazuto
   Handa, Keiko
   Kitahara, Atsuko
   Sumitani, Yoshikazu
   Katsuta, Hidenori
   Tanaka, Toshiaki
   Nishida, Susumu
   Yoshimoto, Katsuhiko
   Ohno, Hideki
   Ishida, Hitoshi
TI Induction of mitochondrial uncoupling enhances VEGF120 but
   reduces MCP-1 release in mature 3T3-L1 adipocytes: Possible regulatory
   mechanism through endogenous ER stress and AMPK-related pathways
SO BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
LA English
DT Article
DE Mitochondria; Uncoupling; MCP-1; VEGF; Adipocytes
ID ENDOTHELIAL GROWTH-FACTOR; ACTIVATED PROTEIN-KINASE; MONOCYTE
   CHEMOATTRACTANT PROTEIN-1; FREE FATTY-ACIDS; ADIPOSE-TISSUE;
   INFLAMMATORY CHANGES; INSULIN-RESISTANCE; OXIDATIVE STRESS; VEGF
   EXPRESSION; GLUCOSE-UPTAKE
AB Although white adipocytes contain a larger number of mitochondria per cytoplasmic volume. adipocyte mitochondrial uncoupling to reduce the efficiency of ATP production on cellular function including secretory regulation of bioactive molecules such as VEGF and MCP-1 remains to be elucidated. Here we induce mitochondrial uncoupling under hypoxia-independent conditions in mature 3T3-L1 adipocytes using a metabolic uncoupler, dinitrophenol (DNP).
   MCP-1 release was significantly decreased by 26% (p < 0.01) in 24 h DNP (30 mu mol/L)-treated adipocytes compared to control cells. In contrast, secreted VEGF(120) lacking a heparin-binding domain was markedly increased 2.0-fold (p < 0.01). CHOP content in these cells also were augmented (p < 0.01), but no significant increase of endogenous oxidative stress was observed. Treatment with thapsigargin, which can induce exogenous endoplasmic reticulum (ER) stress, clearly attenuated MCP-1 release (p < 0.01), but exhibited no effects on VEGF(120) secretion. On the other hand, exogenous H2O2 amplified both MCP-1 and VEGF(120) secretion (p < 0.05). In addition, under chronic activation of AMPK by AICAR, MCP-1 release was significantly diminished (p < 0.05) but VEGF120 secretion was increased (p < 0.01). JNK phosphorylation in mature adipocytes was decreased by treatment with either DNP or AICAR (p < 0.01). Enhanced VEG(120) secretion with either DNP or AICAR was markedly suppressed by PI3K inhibitor LY294002 (p < 0.01).
   Thus, induced mitochondrial uncoupling in adipocytes can reduce MCP-1 release through induction of endogenous ER stress and by reduced JNK activities via chronic activation of AMPK. Under this condition, VEGF(120) secretion was increased through PI3K-dependent pathways, which were chronically activated by AMPK, and not through ER stress. Because the decrease of MCP-1 secretion under mitochondrial uncoupling might attenuate chronic low-grade inflammation by suppressing macrophages recruitment to adipose tissue, clarification of the mechanism might reveal novel therapeutic targets for ameliorating obesity-associated insulin resistance in metabolic syndrome and type 2 diabetes. (C) 2012 Elsevier Inc. All rights reserved.
C1 [Miyokawa-Gorin, Kaoru; Takahashi, Kazuto; Handa, Keiko; Kitahara, Atsuko; Sumitani, Yoshikazu; Katsuta, Hidenori; Tanaka, Toshiaki; Nishida, Susumu; Yoshimoto, Katsuhiko; Ishida, Hitoshi] Kyorin Univ, Sch Med, Dept Internal Med 3, Mitaka, Tokyo 1818611, Japan.
   [Ohno, Hideki] Kyorin Univ, Sch Med, Dept Mol Prevent Med & Sport Sci, Mitaka, Tokyo 1818611, Japan.
C3 Kyorin University; Kyorin University
RP Ishida, H (corresponding author), Kyorin Univ, Sch Med, Dept Internal Med 3, 6-20-2 Shinkawa, Mitaka, Tokyo 1818611, Japan.
EM ishida@ks.kyorin-u.ac.jp
FU Ministry of Education, Science and Culture; Japan Private School
   Promotion Foundation; Grants-in-Aid for Scientific Research [22590993,
   22650154, 21300237] Funding Source: KAKEN
FX This study was supported by Grants - in - Aid for Scientific Research
   from the Ministry of Education, Science and Culture (to H. Ishida) and
   by a grant from the Japan Private School Promotion Foundation.
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NR 35
TC 16
Z9 18
U1 0
U2 16
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0006-291X
EI 1090-2104
J9 BIOCHEM BIOPH RES CO
JI Biochem. Biophys. Res. Commun.
PD MAR 9
PY 2012
VL 419
IS 2
BP 200
EP 205
DI 10.1016/j.bbrc.2012.01.145
PG 6
WC Biochemistry & Molecular Biology; Biophysics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics
GA 913XP
UT WOS:000301911000012
PM 22330806
DA 2025-06-11
ER

PT J
AU Zhao, L
   Wang, QH
   Xu, PL
   Su, X
   Luo, QY
   Ding, YC
AF Zhao, Li
   Wang, Qinghui
   Xu, Pengli
   Su, Xuan
   Luo, Qingyi
   Ding, Yunchuan
TI Evaluation of left ventricular function in ischemia with non-obstructive
   coronary arteries: a research based on adenosine stress myocardial
   contrast echocardiography
SO INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING
LA English
DT Article
DE Adenosine stress echocardiography; Layer-specific strain; Coronary flow
   velocity reserve; Ischemia with non-obstructive coronary arteries;
   Myocardial contrast echocardiography
ID GLOBAL LONGITUDINAL STRAIN; CARDIAC SYNDROME-X; MICROVASCULAR
   DYSFUNCTION; VELOCITY RESERVE; PROGNOSTIC VALUE; PERFUSION; WOMEN;
   ANGINA; FLOW
AB Patients with ischemia with non-obstructive coronary arteries (INOCA) have an increased risk of adverse cardiovascular events in the future, which is widespread but underdiagnosed. The purpose of this study is to explore the application value of adenosine stress myocardial contrast echocardiography (ASMCE) in INOCA disease, so that clinicians can early identify and intervene patients with left ventricular function subclinical impairment in INOCA. We enrolled 118 patients with INOCA by ASMCE and invasive coronary angiography (ICA), 97 of whom had complete data. The study population was divided into two subgroups depending on coronary flow velocity reserve (CFVR): impaired CFVR group (n = 34) and normal CFVR group (n = 63). Global longitudinal strain endocardial myocardial (GLSendo), mid-myocardial (GLSmid) and epicardial myocardial (GLSepi) increased after stress in both groups; transmural strain, wall motion scored index (WMSI) and myocardial perfusion scored index (MPSI) increased and FORCE decreased in impaired CFVR group after stress, but there was no difference in normal group before and after stress. There was no significant difference in left ventricular myocardial mechanical parameters, including Delta GLSendo, Delta GLSmid, Delta GLSepi, GLSendo-epi Reserve, Delta peak strain dispersion (PSD), PSD Reserve between the two groups, but Delta EF, strain reserve and left ventricular contractile reserve (LVCR) in the impaired CFVR group were lower than those in the normal CFVR group, while Delta WMSI and Delta MPSI were increased. CFVR can be a clinically valuable indicator in the ASMCE diagnosis of patients with microvascular angina pectoris in INOCA. In the evaluation of left ventricular function in INOCA patients, attention should be paid not only to myocardial deformation, but also to the dynamic changes of LVCR and myocardial perfusion during peak hyperemia.
C1 [Zhao, Li; Wang, Qinghui; Xu, Pengli; Su, Xuan; Luo, Qingyi; Ding, Yunchuan] Yanan Hosp Kunming City, Dept Ultrasound, Kunming 650051, Yunnan, Peoples R China.
RP Wang, QH (corresponding author), Yanan Hosp Kunming City, Dept Ultrasound, Kunming 650051, Yunnan, Peoples R China.
EM wqh962099@163.com
RI wang, qinghui/AAU-6164-2021
OI Luo, Qingyi/0000-0003-4995-0149
FU kunming Health Commission Grant [2022-09-02-001]
FX This study was supported by the kunming Health Commission Grant (Grant
   Numbers 2022-09-02-001).
CR Al-Mohaissen MA, 2023, TRENDS CARDIOVAS MED, V33, P369, DOI 10.1016/j.tcm.2022.02.007
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NR 24
TC 0
Z9 0
U1 1
U2 2
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1569-5794
EI 1875-8312
J9 INT J CARDIOVAS IMAG
JI Int. J. Cardiovasc. Imaging
PD FEB
PY 2023
VL 39
IS 2
BP 349
EP 357
DI 10.1007/s10554-022-02740-7
EA OCT 2022
PG 9
WC Cardiac & Cardiovascular Systems; Radiology, Nuclear Medicine & Medical
   Imaging
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Radiology, Nuclear Medicine &
   Medical Imaging
GA 8I7XN
UT WOS:000875794900001
PM 36308671
DA 2025-06-11
ER

PT J
AU Vázquez-Ruiz, Z
   Martínez-González, MA
   Vitelli-Storelli, F
   Bes-Rastrollo, M
   Basterra-Gortari, FJ
   Toledo, E
AF Vazquez-Ruiz, Zenaida
   Martinez-Gonzalez, Miguel Angel
   Vitelli-Storelli, Facundo
   Bes-Rastrollo, Maira
   Basterra-Gortari, Francisco Javier
   Toledo, Estefania
TI Effect of Dietary Phenolic Compounds on Incidence of Type 2 Diabetes in
   the "Seguimiento Universidad de Navarra" (SUN) Cohort
SO ANTIOXIDANTS
LA English
DT Article
DE phenolic compounds; diet; diabetes; stilbenes; cohort
ID FOOD-FREQUENCY QUESTIONNAIRE; GLUCOSE-METABOLISM; OXIDATIVE STRESS;
   CARDIOMETABOLIC RISK; INSULIN SENSITIVITY; MEDITERRANEAN DIET; WINE
   CONSUMPTION; POLYPHENOLS; ALCOHOL; HEALTH
AB The global incidence of type 2 diabetes (T2D) has been steadily increasing in recent decades. The Mediterranean dietary pattern has shown a preventive effect on the risk of T2D. Evaluating the association between bioactive compounds such as phenolic compounds (PC) in a Mediterranean cohort could help to better understand the mechanisms implicated in this protection. We evaluated the association between dietary intake of PC and the risk of T2D in a relatively young cohort of 17,821 Spanish participants initially free of T2D, through the University of Navarra Follow-up Project ("Seguimiento Universidad de Navarra" or SUN cohort) after 10 years of median follow-up using time-dependent Cox models. Intake of PC was estimated at baseline and repeatedly at 10-year follow-up using a 136-item validated food frequency and the Phenol-Explorer database. The incidence of T2D was identified by a biennial follow-up, and only medically confirmed cases were included. During 224,751 person-years of follow-up, 186 cases of T2D were confirmed. A suboptimal intake of stilbenes was independently associated with a higher risk of T2D in subjects over 50 years (HR: 1.75, 95% CI: 1.06-2.90, p value < 0.05) after adjusting for potential confounders. Our results suggest that a moderate-high intake of stilbenes can decrease the risk of developing T2D in subjects over 50 years in our cohort.
C1 [Vazquez-Ruiz, Zenaida; Martinez-Gonzalez, Miguel Angel; Bes-Rastrollo, Maira; Basterra-Gortari, Francisco Javier; Toledo, Estefania] Univ Navarra, Dept Prevent Med & Publ Hlth, Inst Invest Sanitaria Navarra IdiSNA, Pamplona 31008, Spain.
   [Vazquez-Ruiz, Zenaida; Martinez-Gonzalez, Miguel Angel; Bes-Rastrollo, Maira; Toledo, Estefania] Carlos III Hlth Inst, Biomed Res Network Ctr Pathophysiol Obes & Nutr C, Madrid 28029, Spain.
   [Martinez-Gonzalez, Miguel Angel] Harvard Univ, Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA.
   [Vitelli-Storelli, Facundo] Univ Leon, Inst Biomed IBIOMED, Grp Invest Interacc Gen Ambiente & Salud GIIGAS, Leon 24004, Spain.
   [Basterra-Gortari, Francisco Javier] Hosp Univ Navarra, Dept Endocrinol & Nutr, Inst Invest Sanitaria Navarra IdiSNA, Pamplona 31008, Spain.
C3 University of Navarra; Harvard University; Harvard T.H. Chan School of
   Public Health; Universidad de Leon; Servicio Navarro de Salud -
   Osasunbidea
RP Toledo, E (corresponding author), Univ Navarra, Dept Prevent Med & Publ Hlth, Inst Invest Sanitaria Navarra IdiSNA, Pamplona 31008, Spain.; Toledo, E (corresponding author), Carlos III Hlth Inst, Biomed Res Network Ctr Pathophysiol Obes & Nutr C, Madrid 28029, Spain.
EM etoledo@unav.es
RI VITELLI STORELLI, FACUNDO EZEQUIEL/HPE-5183-2023; Martinez-Gonzalez,
   Miguel/AAE-7669-2019; Toledo, Estefania/H-6211-2014; Vazquez-Ruiz,
   Zenaida/AAB-7202-2020; BES-RASTROLLO, MAIRA/A-1329-2009
OI Toledo, Estefania/0000-0002-6263-4434; Martinez-Gonzalez, Miguel
   A./0000-0002-3917-9808; Vitelli-Storelli, Facundo/0000-0002-3118-3570;
   Vazquez-Ruiz, Zenaida/0000-0002-6828-9627; BES-RASTROLLO,
   MAIRA/0000-0002-9139-4206
FU Instituto de Salud Carlos III-European Fund for Regional and Economic
   Development (FEDER) [RD06/0045, PI10/02658, PI10/02293, PI13/00615,
   PI14/01668, PI14/01798, PI14/01764, PI17/01795, PI20/00564]; Spanish
   Biomedical Research Centre in Physiopathology of Obesity and Nutrition
   [CB12/03/30017]; Government of Navarra [27/2011, 45/2011, 122/2014];
   University of Navarra
FX The project SUN has received funding from the Instituto de Salud Carlos
   III-European Fund for Regional and Economic Development (FEDER):
   RD06/0045, PI10/02658, PI10/02293, PI13/00615, PI14/01668, PI14/01798,
   PI14/01764, PI17/01795, PI20/00564. Spanish Biomedical Research Centre
   in Physiopathology of Obesity and Nutrition: CB12/03/30017. Government
   of Navarra: 27/2011, 45/2011, 122/2014 as well as the University of
   Navarra.
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NR 69
TC 3
Z9 3
U1 1
U2 4
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD FEB
PY 2023
VL 12
IS 2
AR 507
DI 10.3390/antiox12020507
PG 17
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA 9G6PV
UT WOS:000938273300001
PM 36830064
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Köroglu, E
   Canbakan, B
   Atay, K
   Hatemi, I
   Tuncer, M
   Dobrucali, A
   Sonsuz, A
   Gültepe, I
   Sentürk, H
AF Koroglu, Emine
   Canbakan, Billur
   Atay, Kadri
   Hatemi, Ibrahim
   Tuncer, Murat
   Dobrucali, Ahmet
   Sonsuz, Abdullah
   Gultepe, Ilhami
   Senturk, Hakan
TI Role of oxidative stress and insulin resistance in disease severity of
   non-alcoholic fatty liver disease
SO TURKISH JOURNAL OF GASTROENTEROLOGY
LA English
DT Article
DE Oxidative stress; insulin resistance; non-alcoholic fatty liver disease
ID STEATOHEPATITIS NASH; LIPID-PEROXIDATION; METABOLIC SYNDROME; CHILDREN;
   ANTIOXIDANTS; ACCUMULATION; ASSOCIATION; PARAMETERS; DEFICIENCY;
   STEATOSIS
AB Background/Aims: Oxidative stress and insulin resistance (IR) are major contributors in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). The purpose of this study was to find the relation between oxidative stress parameters and histopathological findings in NAFLD patients with and without insulin resistance (IR).
   Materials and Methods: Thirty-two patients with no alcohol intake and biopsy-proven diagnosis of NAFLD were studied (M/F: 17/15; mean age 46.5+/-11.4 years). Twenty-one NAFLD patients with IR were compared with 11 patients without IR. The fasting insulin level was measured, and the insulin resistance index was calculated using the homeostasis model assessment (HOMA) method. Malondialdehyde (MDA) and superoxide dismutase (SOD) activities were measured in tissue and serum specimens. Glutathione (GH) was measured in tissue homogenates. Nitric oxide (NO), vitamin E and C levels were measured in serum.
   Results: Patients with IR had significantly higher tissue MDA levels (p=0.001) and significantly decreased tissue SOD and GH levels (p=0.001 and 0.002, respectively) than those without IR. The steatosis grade, necroinflammatory grade and stage were significantly higher in patients with IR (p=0.035, 0.003 and 0.001, respectively). HOMA IR significantly correlated with the necroinflammatory grade, stage, tissue MDA, SOD and GH (p=0.013, 0.001, 0.008, 0.001 and 0.001, respectively). Serum MDA (beta=1.88, p=0.002), serum SOD (beta=0.57, p=0.006), tissue MDA (beta=0.22, p=0.006), tissue SOD (beta=1.48, p=0.071) and stage (beta=2.81, p=0.003) were independently associated with increased HOMA IR. Increased MDA [OR: 1.51; 95% CI: (1.03-2.22); p=0.034] was a risk factor for nonalcoholic steatohepatitis (NASH), and increased SOD activity had a preventive effect against NASH [OR: 0.008; 95% CI: (0.001-0.98); p=0.04].
   Conclusion: This study shows that insulin resistance in NAFLD correlates with enhanced oxidative stress. Histopathological disease severity significantly correlated with oxidative stress parameters. These data show that NAFLD patients with IR may have increased risk for disease progression.
C1 [Koroglu, Emine] Kartal Dr Lutfi Kirdar Training & Res Hosp, Dept Gastroenterol, Istanbul, Turkey.
   [Canbakan, Billur; Atay, Kadri; Hatemi, Ibrahim; Tuncer, Murat; Dobrucali, Ahmet; Sonsuz, Abdullah] Istanbul Univ, Dept Gastroenterol, Cerrahpasa Med Sch, Istanbul, Turkey.
   [Gultepe, Ilhami] Bezmialem Vakif Univ, Dept Internal Med, Sch Med, Istanbul, Turkey.
   [Senturk, Hakan] Bezmialem Vakif Univ, Dept Gastroenterol, Sch Med, Istanbul, Turkey.
C3 Istanbul Kartal Dr Lutfi Kirdar Training & Research Hospital; Istanbul
   University; Istanbul University - Cerrahpasa; Bezmialem Vakif
   University; Bezmialem Vakif University
RP Köroglu, E (corresponding author), Kartal Dr Lutfi Kirdar Training & Res Hosp, Dept Gastroenterol, Istanbul, Turkey.
EM dreminesatir@gmail.com
RI Hatemi, Ali/AAA-3618-2020; Tuncer, Mehmet/AAA-9186-2020; Tahan,
   Veysel/K-4806-2019; Dobrucali, Ahmet/AAA-8343-2020; Sonsuz,
   Abdullah/U-2295-2018
OI Gultepe, Ilhami/0000-0001-9219-2350; Sonsuz,
   Abdullah/0000-0002-8336-5472
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NR 35
TC 51
Z9 58
U1 1
U2 15
PU AVES
PI SISLI
PA BUYUKDERE CAD 105-9, MECIDIYEKOY, SISLI, ISTANBUL 34394, TURKEY
SN 1300-4948
EI 2148-5607
J9 TURK J GASTROENTEROL
JI Turk. J. Gastroenterol.
PD JUL
PY 2016
VL 27
IS 4
BP 361
EP 366
DI 10.5152/tjg.2016.16106
PG 6
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA DV2JQ
UT WOS:000382747100011
PM 27458852
DA 2025-06-11
ER

PT J
AU Chae, JS
   Paik, JK
   Kang, R
   Kim, M
   Choi, Y
   Lee, SH
   Lee, JH
AF Chae, Jey Sook
   Paik, Jean Kyung
   Kang, Ryungwoo
   Kim, Minjoo
   Choi, Yongin
   Lee, Sang-Hyun
   Lee, Jong Ho
TI Mild weight loss reduces inflammatory cytokines, leukocyte count, and
   oxidative stress in overweight and moderately obese participants treated
   for 3 years with dietary modification
SO NUTRITION RESEARCH
LA English
DT Article
DE Overweight/obese; Diet-induced, long-term, mild weight reduction;
   Proinflammatory cytokines; Leukocyte count; Oxidative stress
ID BLOOD-CELL COUNT; NECROSIS-FACTOR-ALPHA; LOW-CALORIE DIET; METABOLIC
   SYNDROME; INTERLEUKIN-6 LEVELS; OXIDIZED LDL; HEALTHY; ASSOCIATION;
   BIOMARKERS; CORONARY
AB Obesity-induced oxidative stress and inflammation are involved in the pathogenesis of cardiovascular disease. We investigated whether diet-induced, long-term, mild weight loss improved proinflammatory cytokine levels, leukocyte count, and oxidative stress. Overweight/obese participants (25 <= body mass index < 34 kg/m(2), N = 122, 30-59 years) joined a 3-year-long clinical intervention involving daily 100-kcal calorie deficits. Successful weight loss was defined as a reduction in initial body weight equal to 2 kg after the clinical intervention period. Body weight in the successful mild weight loss group (SWL, n = 50) changed 5.4% (-4.16 +/- 0.31 kg) compared to 0.05 +/- 0.14 kg in the unsuccessful weight loss group (n = 49). After 3 years, SWL participants exhibited significantly reduced insulin, triglycerides, total and low-density lipoprotein cholesterol, free fatty acids, and leukocyte count (P = .030). Furthermore, in the SWL group, serum interleukin (IL)-1 beta, IL-6, and urinary 8-epi-prostaglandin (PG)F-2 alpha were significantly reduced (45%, 30%, and 14%, respectively). In contrast, the unsuccessful weight loss group exhibited significant increases in percentage of body fat, waist circumference, oxidized low-density lipoprotein, and tumor necrosis factor-alpha, as well as a significant decrease in high-density lipoprotein cholesterol. After adjusting for baseline values, the 2 groups demonstrated significantly different percentage of body fat, waist circumference, leukocyte count (P = .018), insulin, IL-6 (P = .031), IL-1 beta (P < .001), and tumor necrosis factor-alpha (P < .001), as well as urinary 8-epi-PGF(2 alpha) (P = .036). A positive correlation existed between IL-1 beta and urinary 8-epi-PGF(2 alpha) (r = 0.435, P < .001) and between changes in IL-6 and urinary 8-epi-PGF(2 alpha) (r = 0.393, P < .001). Long-term mild weight loss reduces inflammatory cytokine levels, leukocyte counts, and oxidative stress and may reverse the elevated oxidative stress induced by inflammatory mediators in the overweight and obese. (C) 2013 Elsevier Inc. All rights reserved.
C1 [Chae, Jey Sook; Paik, Jean Kyung; Lee, Jong Ho] Yonsei Univ, Res Inst Sci Aging, Seoul 120749, South Korea.
   [Chae, Jey Sook; Paik, Jean Kyung; Kang, Ryungwoo; Kim, Minjoo; Choi, Yongin; Lee, Jong Ho] Yonsei Univ, Dept Food & Nutr, Natl Res Lab Clin Nutrigenet Nutrigen, Seoul 120749, South Korea.
   [Lee, Sang-Hyun] Natl Hlth Insurance Corp Ilsan Hosp, Dept Family Practice, Goyang Si, South Korea.
C3 Yonsei University; Yonsei University
RP Lee, JH (corresponding author), Yonsei Univ, Coll Human Ecol, Dept Food & Nutr, 134 Shinchon Dong, Seoul 120749, South Korea.
EM jhleeb@yonsei.ac.kr
RI Kim, Minjoo/AEN-5516-2022; Kang, Hyun-Seung/J-5365-2012
FU National Research Foundation, Ministry of Education, Science and
   Technology, Republic of Korea [2011-0016444, M10642120002-06N4212-00210,
   2011-0000068]
FX This work was supported by the National Research Foundation, Ministry of
   Education, Science and Technology (Midcareer Researcher Program:
   2011-0016444, M10642120002-06N4212-00210, and 2011-0000068), Republic of
   Korea.
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NR 44
TC 52
Z9 65
U1 0
U2 9
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0271-5317
J9 NUTR RES
JI Nutr. Res.
PD MAR
PY 2013
VL 33
IS 3
BP 195
EP 203
DI 10.1016/j.nutres.2013.01.005
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 115WP
UT WOS:000316842900004
PM 23507225
DA 2025-06-11
ER

PT J
AU Corica, D
   Aversa, T
   Ruggeri, RM
   Cristani, M
   Alibrandi, A
   Pepe, G
   De Luca, F
   Wasniewska, M
AF Corica, Domenico
   Aversa, Tommaso
   Ruggeri, Rosaria Maddalena
   Cristani, Mariateresa
   Alibrandi, Angela
   Pepe, Giorgia
   De Luca, Filippo
   Wasniewska, Malgorzata
TI Could AGE/RAGE-Related Oxidative Homeostasis Dysregulation Enhance
   Susceptibility to Pathogenesis of Cardio-Metabolic Complications in
   Childhood Obesity?
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Article
DE oxidative stress; advanced glycation end-products; cardiometabolic risk;
   sRAGE; AGEs/sRAGE-ratio; advanced oxidation-protein products
ID GLYCATION END-PRODUCTS; CHOLESTEROL RATIO; GLYOXALASE-I; RISK; STRESS;
   OVERWEIGHT; CHILDREN; RECEPTORS; MARKERS; INDEX
AB Background: Advanced glycation end-products (AGEs) and their cell receptor (RAGE) are involved in the pathophysiology of cardio-metabolic diseases. Interaction of AGEs with RAGE results in increased generation of oxygen radicals and pro-inflammatory cytokines. Circulating soluble RAGE (sRAGE) interacts with AGEs in order to counterbalance the negative effects of AGEs-RAGE interaction.
   Objectives: To define factors influencing AGEs, sRAGE, AGEs/sRAGE-ratio, and advanced oxidation-protein products (AOPPs) levels and to investigate changes in oxidative balance among overweight/obese children.
   Materials and methods: Cross-sectional, one Center, case-control study included 41 overweight and obese children aged between 5 and 16 years and 36 lean matched controls. Inclusion criteria were: BMI >= 1 SD; term birth; no genetic or endocrine causes of obesity; no associated chronic diseases neither chronic therapies. All patients underwent clinical and biochemical investigations (lipid and glucose profiles, liver, renal and thyroid function tests, uric acid, C-reactive protein (CRP), AGEs, sRAGE, and AOPPs serum concentrations). Significance was established at 0.050.
   Results: AOPPs, AGEs/sRAGE-ratio, HOMA-IR, triglycerides, triglycerides/HDL-ratio, total cholesterol (TC)/HDL-ratio, atherogenic-index of plasma (AIP), uric acid, CRP were significantly higher, whereas sRAGE and HDL were significantly lower in overweight/obese children than controls. sRAGE was significantly negatively correlated with BMI SD, TC/HDL-ratio, CRP, AOPPs, and positively with HDL. AGE/sRAGE-ratio and AOPPs were significantly positively correlated with BMI SD, TC/HDL-ratio, AIR CRP, and negatively with HDL. BMI SD was independently associated with AGEs/sRAGE-ratio (B = 0.06; p = 0.008), AOPPs (B = 0.13; p = 0.02), and sRAGE (B = -73.18; p = 0.000).
   Conclusions: We demonstrated, for the first time in a pediatric cohort, a significant higher value of AGEs/sRAGE-ratio among overweight/obese children, expression of a relative shift to oxidant from anti-oxidant factors, suggesting an AGE/RAGE-related oxidative homeostasis dysregulation that could enhance susceptibility to oxidative/inflammatory tissues damage. Severity of overweight, influencing the increase of oxidative stress in human organism and even in children, may contribute to the pathogenesis of long-term cardiovascular and metabolic alterations.
C1 [Corica, Domenico; Aversa, Tommaso; Pepe, Giorgia; De Luca, Filippo; Wasniewska, Malgorzata] Univ Messina, Dept Human Pathol Adulthood & Childhood, Unit Pediat, Messina, Italy.
   [Ruggeri, Rosaria Maddalena] Univ Messina, Dept Clin & Expt Med, Unit Endocrinol, Messina, Italy.
   [Cristani, Mariateresa] Univ Messina, Dept Chem Biol Pharmaceut & Environm Sci, Messina, Italy.
   [Alibrandi, Angela] Univ Messina, Dept Econ, Messina, Italy.
C3 University of Messina; University of Messina; University of Messina;
   University of Messina
RP Corica, D (corresponding author), Univ Messina, Dept Human Pathol Adulthood & Childhood, Unit Pediat, Messina, Italy.
EM coricadomenico@hotmail.com
RI Corica, Domenico/AAC-7112-2021; Ruggeri, Rosaria/AAB-7364-2019; Pepe,
   Giorgia/AAP-8204-2020; Wasniewska, Malgorzata/AAR-9900-2021; Aversa,
   Tommaso/O-2490-2014
OI Pepe, Giorgia/0000-0003-1130-829X; Aversa, Tommaso/0000-0002-1754-6822
CR Accacha S, 2013, HORM RES PAEDIAT, V80, P318, DOI 10.1159/000354831
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NR 33
TC 32
Z9 32
U1 0
U2 1
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD JUN 28
PY 2019
VL 10
AR 426
DI 10.3389/fendo.2019.00426
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA IF7OQ
UT WOS:000473273900001
PM 31316471
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Korandji, C
   Zeller, M
   Guilland, JC
   Collin, B
   Lauzier, B
   Sicard, P
   Duvillard, L
   Goirand, F
   Moreau, D
   Cottin, Y
   Rochette, L
   Vergely, C
AF Korandji, C.
   Zeller, M.
   Guilland, J. C.
   Collin, B.
   Lauzier, B.
   Sicard, P.
   Duvillard, L.
   Goirand, F.
   Moreau, D.
   Cottin, Y.
   Rochette, L.
   Vergely, C.
TI Time course of asymmetric dimethylarginine (ADMA) and oxidative stress
   in fructose-hypertensive rats: A model related to metabolic syndrome
SO ATHEROSCLEROSIS
LA English
DT Article
DE ADMA; Oxidative stress; NAD(P)H oxidase; Endothelial relaxation;
   Fructose-fed rat
ID NITRIC-OXIDE SYNTHASE; INSULIN-RESISTANCE; ENDOTHELIAL DYSFUNCTION;
   VASCULAR FUNCTION; CONSUMPTION; MODULATION; EXPRESSION; PATHWAY; TISSUE
AB Objective: Asymmetric dimethylarginine (ADMA) is an endogenous modulator of endothelial function and oxidative stress, and increased levels of this molecule have been reported in some metabolic disorders and cardiovascular diseases. The aim of this work was to analyze the time course of dimethylarginine compounds and oxidative stress levels and the relationship between these and cardiovascular function in fructose-hypertensive rats.
   Methods and results: 90 male Sprague-Dawley rats were randomized into 2 groups, fed for 3 months with standard (C) chow supplemented or not with fructose (F, 60%). After sacrifice at different weeks (W), the aorta and plasma were harvested to assess the vascular and biochemical parameters. Our work showed that the plasma levels of ADMA in the fructose-fed rats increased after 2 weeks of the diet (1.6 +/- 0.3 mu M vs. 1.2 +/- 0.3 mu M, p < 0.05) with no changes in plasma levels of either SDMA or l-arginine and after an increase in glycemia. Levels of vascular oxidative stress, estimated in aortic segments using an oxidative fluorescence technique, were higher in the F group (W2: 1.14 +/- 0.2% vs. 0.33 +/- 0.02%, p < 0.01). An increase in expression levels of nitrotyrosine (3-fold) and iNOS (2-fold) were noted in the fructose-fed rats. After 1 month, this was associated with a significant increase in NAD(P)H oxidase activity. Concerning vascular function, a 15% decrease in maximal endothelium-dependent relaxation was found in the aorta of the F group. Our work showed that the presence of exogenous L-MMA, an inhibitor of NO synthase, was associated with a significant reduction in endothelium-dependent relaxation in isolated aorta rings of the C group; this effect was not observed in the vessels of fructose-fed rats.
   Conclusion: Our findings suggest that the elevated levels of ADMA observed could in part be secondary to the early development of oxidative stress associated with the development of hypertension. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
C1 [Zeller, M.] Univ Burgundy, Lab Cardiovasc & Expt Pathophysiol & Pharmacol, IFR 100, Sante STIC,STIC,Fac Med, F-21000 Dijon, France.
   [Zeller, M.] Univ Burgundy, Lab Cardiovasc & Expt Pathophysiol & Pharmacol, IFR 100, Sante STIC,STIC,Fac Pharm, F-21000 Dijon, France.
   [Zeller, M.; Cottin, Y.] Univ Hosp, Dept Cardiol, Dijon, France.
   [Duvillard, L.] Univ Hosp, Dept Biochem, Dijon, France.
C3 Universite Bourgogne Europe; Universite Bourgogne Europe; Universite
   Bourgogne Europe; CHU Dijon Bourgogne; Universite Bourgogne Europe; CHU
   Dijon Bourgogne
RP Zeller, M (corresponding author), Univ Burgundy, Lab Cardiovasc & Expt Pathophysiol & Pharmacol, IFR 100, Sante STIC,STIC,Fac Med, 7 Bd Jeanne dArc, F-21000 Dijon, France.
EM marianne.zeller@u-bourgogne.fr
RI Sicard, Pierre/JCE-3774-2023; COTTIN, YVES/ABA-4622-2020; Lauzier,
   Benjamin/D-3570-2015; Sicard, Pierre/N-7310-2018; VERGELY,
   CATHERINE/L-9534-2015
OI Lauzier, Benjamin/0000-0002-1370-6155; Sicard,
   Pierre/0000-0001-5837-3916; VERGELY, CATHERINE/0000-0003-4009-776X;
   Rochette, Luc/0000-0001-9973-8803
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NR 34
TC 30
Z9 31
U1 0
U2 11
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0021-9150
EI 1879-1484
J9 ATHEROSCLEROSIS
JI Atherosclerosis
PD FEB
PY 2011
VL 214
IS 2
BP 310
EP 315
DI 10.1016/j.atherosclerosis.2010.11.014
PG 6
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 712FV
UT WOS:000286651100013
PM 21146169
DA 2025-06-11
ER

PT J
AU Sovova, E
   Nakladalová, M
   Kaletova, M
   Sovova, M
   Radova, L
   Kribska, M
AF Sovova, Eliska
   Nakladalova, Marie
   Kaletova, Marketa
   Sovova, Marketa
   Radova, Lenka
   Kribska, Michaela
TI Which health professionals are most at risk for cardiovascular disease?
   Or do not be a manager
SO INTERNATIONAL JOURNAL OF OCCUPATIONAL MEDICINE AND ENVIRONMENTAL HEALTH
LA English
DT Article
DE Cardiovascular; Event; Hospital employees; Risk factors
ID CARDIOMETABOLIC RISK; OCCUPATIONAL STRESS; HEART-DISEASE; WORK STRESS;
   PHYSICIANS; LIFE; ANESTHESIOLOGISTS; PREVALENCE; TIME; CARE
AB Health care workers constitute a high-risk occupational category owing to the character of their work that includes high-risk environment, shift work and mental as well as physical stress. In occupational medicine, caring for their health condition should be a priority and include measures aimed at preventing cardiovascular diseases. The study aimed at determining the prevalence of cardiovascular disease (CVD) risk factors in employees of a large hospital and assessing their effect on the incidence of cardiovascular events.
   The group comprised 3124 employees with a mean age of 36.1 years (SD = 11.4), out of whom 562 were males (mean age of 37.1 years, range: 18-72; SD = 12.26) and 2562 were females (mean age of 35.9 years, range: 18-68; SD = 11.24). At their initial examination, the employees filled in a questionnaire on basic CVD risk factors (according to valid recommendations). This was supplemented with objective data to determine the risk of CVD using valid charts. From this group, a subset of persons at a high or intermediate risk was selected, comprising 247 individuals with a mean age of 54.1 years (SD = 5.73). After 5-9 years (mean 7.24 +/- 1.38 years), they either underwent another examination or their health status was ascertained by phone or in a computer database. The end point was the incidence of cardiovascular events (sudden death, acute myocardial infarction, unstable angina pectoris, percutaneous coronary intervention, cardiac failure, stroke or transient ischemic attack).
   The end point was noted in a total of 15 males (6.07%) and 6 females (2.42%), being statistically significantly present in managers (males p < 0.00007, females p < 0.00001), male physicians/surgeons (p < 0.025), tertiary-educated males (p < 0.0095), female smokers (p < 0.015), male ex-smokers (p < 0.007), overweight or obese males (p < 0.02) and those with the waist-to-hip ratio above 1.0 (p < 0.005).
   Cardiovascular events are most likely to occur in obese male physicians/surgeons holding managerial positions and in female managers.
C1 [Sovova, Eliska; Kaletova, Marketa] Palacky Univ, Dept Internal Med Cardiol 1, Univ Hosp Olomouc, CR-77147 Olomouc, Czech Republic.
   [Sovova, Eliska; Nakladalova, Marie; Kaletova, Marketa; Sovova, Marketa; Kribska, Michaela] Palacky Univ, Fac Med & Dent, CR-77147 Olomouc, Czech Republic.
   [Nakladalova, Marie; Kribska, Michaela] Palacky Univ, Dept Occupat Med, Univ Hosp Olomouc, CR-77147 Olomouc, Czech Republic.
   [Radova, Lenka] Palacky Univ, Inst Mol & Translat Med, Fac Med & Dent, CR-77147 Olomouc, Czech Republic.
C3 University Hospital Olomouc; Palacky University Olomouc; Palacky
   University Olomouc; University Hospital Olomouc; Palacky University
   Olomouc; Palacky University Olomouc
RP Sovova, E (corresponding author), Univ Hosp Olomouc, Dept Internal Med Cardiol 1, IP Pavlova 5, Olomouc 77520, Czech Republic.
EM eliska.sovova@fnol.cz
RI Radova, Lenka/I-1182-2014
OI Radova, Lenka/0000-0001-8103-148X; Nakladalova,
   Marie/0000-0002-7766-3158
FU Operational Programme Research and Development for Innovations
   [CZ.1.05/2.1.00/01.0030]
FX The infrastructural part of the project (Institute of Molecular and
   Translational Medicine) was supported by the Operational Programme
   Research and Development for Innovations (project
   CZ.1.05/2.1.00/01.0030).
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NR 24
TC 11
Z9 11
U1 0
U2 12
PU NOFER INST OCCUPATIONAL MEDICINE, POLAND
PI LODZ
PA SW TERESY 8, LODZ, 91-348, POLAND
SN 1232-1087
EI 1896-494X
J9 INT J OCCUP MED ENV
JI Int. J. Occup. Med. Environ. Health
PY 2014
VL 27
IS 1
BP 71
EP 77
DI 10.2478/s13382-014-0228-1
PG 7
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA AD6BO
UT WOS:000333338500008
PM 24488775
OA gold
DA 2025-06-11
ER

PT J
AU Petersen, JW
   Pepine, CJ
AF Petersen, John W.
   Pepine, Carl J.
TI Microvascular coronary dysfunction and ischemic heart disease: Where are
   we in 2014?
SO TRENDS IN CARDIOVASCULAR MEDICINE
LA English
DT Article
ID SYNDROME EVALUATION WISE; CARDIAC SYNDROME-X; CONVERTING
   ENZYME-INHIBITION; LEFT-VENTRICULAR FUNCTION; STABLE ANGINA-PECTORIS;
   ARTERY-DISEASE; CHEST-PAIN; NATIONAL-HEART; CARDIOVASCULAR EVENTS;
   MYOCARDIAL-ISCHEMIA
AB Many patients with angina and signs of myocardial ischemia on stress testing have no significant obstructive epicardial coronary disease. There are many potential coronary and non-coronary mechanisms for ischemia without obstructive epicardial coronary disease, and prominent among these is coronary microvascular and/or endothelial dysfunction. Patients with coronary microvascular and/or endothelial dysfunction are often at increased risk of adverse cardiovascular events, including ischemic events and heart failure despite preserved ventricular systolic function. In this article, we will review the diagnosis and treatment of coronary microvascular and endothelial dysfunction, discuss their potential contribution to heart failure with preserved ejection fraction, and highlight recent advances in the evaluation of atherosclerotic morphology in these patients, many of whom have non-obstructive epicardial disease. (C) 2015 Elsevier Inc. All rights reserved.
C1 [Petersen, John W.; Pepine, Carl J.] Univ Florida, Div Cardiovasc Med, Gainesville, FL 32610 USA.
C3 State University System of Florida; University of Florida
RP Pepine, CJ (corresponding author), Univ Florida, Div Cardiovasc Med, 1600 SW Archer Rd,POB 100277, Gainesville, FL 32610 USA.
EM carl.pepine@medicine.ufl.edu
OI Petersen, John/0000-0003-0401-5421; Pepine, Carl/0000-0002-6011-681X
FU NCATS NIH HHS [UL1 TR000064, UL1 TR001427] Funding Source: Medline;
   NHLBI NIH HHS [R01 HL090957] Funding Source: Medline
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NR 40
TC 25
Z9 32
U1 0
U2 10
PU ELSEVIER SCIENCE LONDON
PI LONDON
PA 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND
SN 1050-1738
J9 TRENDS CARDIOVAS MED
JI Trends Cardiovasc. Med.
PD FEB
PY 2015
VL 25
IS 2
BP 98
EP 103
DI 10.1016/j.tcm.2014.09.013
PG 6
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA CD0RE
UT WOS:000350780800005
PM 25454903
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Hartwig, FP
   Ataullahjan, A
   Adair, L
   Goncalves, H
   Horta, B
   Lee, NET
   Martorell, R
   Menezes, AMB
   Motta, JVD
   Norris, S
   Ramirez-Zea, M
   Richter, L
   Bhutta, Z
   Stein, A
   Victora, C
AF Hartwig, Fernando Pires
   Ataullahjan, Anushka
   Adair, Linda
   Goncalves, Helen
   Horta, Bernardo
   Lee, Nanette
   Martorell, Reynaldo
   Menezes, Ana Maria B.
   Motta, Janaina Vieira dos Santos
   Norris, Shane
   Ramirez-Zea, Manuel
   Richter, Linda
   Bhutta, Zulfiqar
   Stein, Aryeh
   Victora, Cesar
TI Women's health and well-being in five birth cohorts from low- and
   middle-income countries: Domains and their associations with early-life
   conditions
SO JOURNAL OF GLOBAL HEALTH
LA English
DT Article
ID WEIGHT-GAIN; ADULT HEALTH; PROFILE; DISEASE; CHILD; AGE
AB Background Women's health and well-being (WHW) have been receiving growing attention, but limited progress has been made on how to measure its different domains in low- and middle-income countries (LMICs). We used data from five long-term birth cohorts in Brazil, Guatemala, the Philippines and South Africa to explore different domains of adult WHW, and how these domains relate to early life exposures. Methods Based upon an a priori conceptualisation of eight postulated WHW outcomes available in the data, we grouped them as follows: human capital (intelligence quotient, schooling, height, and teenage childbearing), metabolic health (body mass index and metabolic syndrome score), and psychological (happiness and Self-Reported Questionnaire (SRQ) scores). Correlation analyses confirmed the variables theoretically belonging to the same dimension of WHW were statistically related. We then applied principal component analysis to each group of variables separately and used the first principal component as a summary quantitative measure of the corresponding WHW dimension. Finally, we assessed the association of each domain with a range of early-life factors: wealth, maternal education, maternal height, water, and sanitation, birthweight, length at two years and development quotient in mid-childhood. Results The three domains were largely uncorrelated. Early determinants were positively associated with human capital, while birth order was negatively associated. Fewer associations were found for the metabolic or psychological components. Birthweight and weight at age two years were inversely associated with metabolic health. Maternal education was associated with better psychological health. Conclusions Our findings indicate that WHW is multidimensional, with most women in the cohorts being compromised in one or more domains while few women scored highly in all three domains. Our analyses are limited by lack of data on adolescent exposures and on other relevant WHW dimensions such as safety, agency, empowerment, and violence. Further research is needed in LMICs for identifying and measuring the multiple domains of WHW.
C1 [Hartwig, Fernando Pires; Goncalves, Helen; Horta, Bernardo; Menezes, Ana Maria B.; Motta, Janaina Vieira dos Santos; Victora, Cesar] Univ Fed Pelotas, Postgrad Program Epidemiol, Pelotas, Brazil.
   [Ataullahjan, Anushka; Bhutta, Zulfiqar] Hosp Sick Children, Ctr Global Child Hlth, Toronto, ON, Canada.
   [Adair, Linda] Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Nutr, Chapel Hill, NC USA.
   [Lee, Nanette] Univ San Carlos, USC Off Populat Studies Fdn, Cebu, Philippines.
   [Martorell, Reynaldo; Stein, Aryeh] Emory Univ, Rollins Sch Publ Hlth, Hubert Dept Global Hlth, Atlanta, GA USA.
   [Norris, Shane] Univ Witwatersrand, Fac Hlth Sci, Sch Publ Hlth, SAMRC Pathways Hlth Res Unit, Johannesburg, South Africa.
   [Ramirez-Zea, Manuel] Inst Nutr Cent Amer & Panama, INCAP Res Ctr Prevent Chron Dis, Guatemala City, Guatemala.
   [Richter, Linda] Univ Witwatersrand, Natl Res Fdn Ctr Excellence Human Dev, Fac Hlth Sci, Sch Publ Hlth, Johannesburg, South Africa.
   [Bhutta, Zulfiqar] Aga Khan Univ, Inst Global Hlth & Dev, Karachi, Pakistan.
   [Victora, Cesar] Univ Fed Pelotas, Int Ctr Equ Hlth, Pelotas, Brazil.
C3 Universidade Federal de Pelotas; University of Toronto; Hospital for
   Sick Children (SickKids); University of North Carolina; University of
   North Carolina Chapel Hill; University of San Carlos; Emory University;
   Rollins School Public Health; University of Witwatersrand; Institute of
   Nutrition of Central America & Panama (INCAP); University of
   Witwatersrand; Aga Khan University; Universidade Federal de Pelotas
RP Hartwig, FP (corresponding author), Univ Fed Pelotas, Rua Marechal Deodoro 1160, Pelotas, Brazil.
EM fernandophartwig@gmail.com
RI Bhutta, Zulfiqar/ADZ-0156-2022; Ataullahjan, Anushka/AAV-8082-2021;
   Martin-Prevel, Yves/E-7637-2011; dos Santos Motta,
   Janaína/AAH-4968-2019; Hartwig, Fernando/AAG-5578-2020; Horta,
   Bernardo/A-7604-2008
FU Wellcome Trust [101815/Z/13/Z, 082554/Z/07/Z]; Bill & Melinda Gates
   Foundation [OPP1164115]; Wellcome Trust [082554/Z/07/Z] Funding Source:
   Wellcome Trust
FX Funding for the research contributing to this paper was provided by the
   Wellcome Trust (grant #101815/Z/13/Z). The COHORTS consortium was
   established through a grant from the Wellcome Trust (# 082554/Z/07/Z)
   and recent data collection was supported by a grant to Emory University
   from Bill & Melinda Gates Foundation (OPP1164115).
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NR 43
TC 1
Z9 1
U1 0
U2 2
PU INT SOC GLOBAL HEALTH
PI EDINBURGH
PA CALEDONIAN EXCHANGE, 19A CANNING ST, EDINBURGH, Lothian, ENGLAND
SN 2047-2978
EI 2047-2986
J9 J GLOB HEALTH
JI J. Glob. Health
PY 2024
VL 14
AR 04137
DI 10.7189/jogh.14.04137
PG 12
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA F1U8Z
UT WOS:001307748300001
PM 39148472
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Colak, D
   Kucic, AC
   Pintar, T
   Gaspirc, B
   Gaspersic, R
AF Colak, Dejana
   Cmok Kucic, Alja
   Pintar, Tadeja
   Gaspirc, Boris
   Gaspersic, Rok
TI Periodontal and systemic health of morbidly obese patients eligible for
   bariatric surgery: a cross-sectional study
SO BMC ORAL HEALTH
LA English
DT Article
DE Obesity; Bariatric surgery; Periodontist; Gingivitis; Hypertension;
   Cardiovascular risk factors
ID POLYCYSTIC-OVARY-SYNDROME; BLOOD-PRESSURE; METABOLIC SYNDROME;
   DIAGNOSTIC-CRITERIA; STAGING SYSTEM; RISK-FACTORS; ORAL-HEALTH;
   ASSOCIATION; DISEASE; HYPERTENSION
AB Background In obese patients, periodontitis might be associated with deprived systemic health. Edmonton obesity staging system (EOSS) is a new tool for classification of obesity that considers the metabolic, physical, and psychological health. The cross-sectional study aimed to evaluate the periodontal status of morbidly obese patients eligible for bariatric surgery and the association between periodontitis, obesity-related comorbidities, and EOSS. Methods Morbidly obese patients eligible for bariatric surgery underwent detailed periodontal examination and were divided into the periodontitis group (PG) and the non-periodontitis group (NPG). The medical and demographic data were obtained from medical files, while behavioural data were obtained by the interview. Descriptive statistics and simple statistical tests were used to summarise the characteristics of the sample and the differences between PG and NPG. The logistic regression models were used to calculate the association (odds ratio (OR)) between periodontitis and obesity-related diseases and EOSS. Results The study included 79 patients, with an average BMI of 44.6 kg/m(2) (SD = 7.2). The prevalence of periodontitis was 65% (CI 95% 53%-75%). PG patients (n = 51) were older, more often smokers and were more often hypertensive than NPG patients (n = 28) (p < 0.05). Hypertension was positively associated with periodontitis with adjusted OR 3.98 (95% CI 1.23-12.8; p = 0.021)) and age with adjusted OR 1.06, (95% CI 1.01-1.13; p = 0.038)), while other tested conditions (diabetes, dyslipidaemia, and smoking habits) did not show significant association with periodontitis. Periodontitis did not correlate with EOSS or other obesity-related comorbidities (p > 0.05). Conclusion The morbidly obese patients eligible for bariatric surgery show a high prevalence of periodontitis and, therefore, are advised to be examined by a dentist before undergoing surgery. They have higher odds of hypertension but not of other obesity-related diseases or higher stages of EOSS. The medical personnel should raise awareness among obese patients on the potential association of poor periodontal health with hypertension.
C1 [Colak, Dejana; Cmok Kucic, Alja; Gaspirc, Boris; Gaspersic, Rok] Univ Med Ctr Ljubljana, Dent Clin, Dept Oral Dis & Periodontol, Hrvatski Trg 6, Ljubljana 1000, Slovenia.
   [Pintar, Tadeja] Univ Med Ctr, Dept Abdominal Surg, Ljubljana, Slovenia.
   [Colak, Dejana; Cmok Kucic, Alja; Pintar, Tadeja; Gaspirc, Boris; Gaspersic, Rok] Univ Ljubljana, Fac Med, Ljubljana, Slovenia.
C3 University Medical Centre Ljubljana; University Medical Centre
   Ljubljana; University of Ljubljana
RP Colak, D (corresponding author), Univ Med Ctr Ljubljana, Dent Clin, Dept Oral Dis & Periodontol, Hrvatski Trg 6, Ljubljana 1000, Slovenia.; Colak, D (corresponding author), Univ Ljubljana, Fac Med, Ljubljana, Slovenia.
EM dejana.colak.23@gmail.com
RI GASPIRC, BORIS/AAF-3504-2021; Pintar, Tadeja/HNS-7436-2023
OI Gaspersic, Rok/0000-0002-3765-7378; Colak, Dejana/0000-0002-9694-7148
FU ARRS program [P3-0293]
FX The study was funded by ARRS program P3-0293.
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NR 96
TC 4
Z9 4
U1 0
U2 5
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1472-6831
J9 BMC ORAL HEALTH
JI BMC Oral Health
PD MAY 13
PY 2022
VL 22
IS 1
AR 174
DI 10.1186/s12903-022-02207-0
PG 11
WC Dentistry, Oral Surgery & Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dentistry, Oral Surgery & Medicine
GA 1G0QI
UT WOS:000795561400002
PM 35562737
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Jovanovic, I
   Tesic, M
   Djordjevic-Dikic, A
   Giga, V
   Beleslin, B
   Aleksandric, S
   Boskovic, N
   Petrovic, O
   Marjanovic, M
   Vratonjic, J
   Paunovic, I
   Ivanovic, B
   Trifunovic-Zamaklar, D
AF Jovanovic, Ivana
   Tesic, Milorad
   Djordjevic-Dikic, Ana
   Giga, Vojislav
   Beleslin, Branko
   Aleksandric, Srdjan
   Boskovic, Nikola
   Petrovic, Olga
   Marjanovic, Marija
   Vratonjic, Jelena
   Paunovic, Ivana
   Ivanovic, Branislava
   Trifunovic-Zamaklar, Danijela
TI Role of different echocardiographic modalities in the assessment of
   microvascular function in women with ischemia and no obstructive
   coronary arteries
SO JOURNAL OF CLINICAL ULTRASOUND
LA English
DT Review
DE coronary flow velocity reserve; INOCA; left ventricular global
   longitudinal strain; microvascular dysfunction; stress echocardiography
ID CARDIAC SYNDROME-X; PRESERVED EJECTION FRACTION; TRANSTHORACIC
   DOPPLER-ECHOCARDIOGRAPHY; GLOBAL LONGITUDINAL STRAIN; FLOW VELOCITY
   RESERVE; HEART-FAILURE; CHEST-PAIN; PROGNOSTIC VALUE; ANGINA-PECTORIS;
   MYOCARDIAL DYSFUNCTION
AB This review summarizes current knowledge about echocardiographic modalities used to assess microvascular function and left ventricular (LV) systolic function in women with ischemia and no obstructive coronary arteries (INOCA). Although the entire pathophysiological background of this clinical entity still remains elusive, it is primarily linked to microvascular dysfunction which can be assessed by coronary flow velocity reserve. Subtle impairments of LV systolic function in women with INOCA are difficult to assess by interpretation of wall motion abnormalities. LV longitudinal function impairment is considered to be an early marker of subclinical systolic dysfunction and can be assessed by global longitudinal strain quantification.
C1 [Jovanovic, Ivana; Tesic, Milorad; Djordjevic-Dikic, Ana; Giga, Vojislav; Beleslin, Branko; Aleksandric, Srdjan; Boskovic, Nikola; Petrovic, Olga; Marjanovic, Marija; Vratonjic, Jelena; Paunovic, Ivana; Ivanovic, Branislava; Trifunovic-Zamaklar, Danijela] Univ Clin Ctr Serbia, Clin Cardiol, Visegradska 26, Belgrade 11000, Serbia.
   [Tesic, Milorad; Djordjevic-Dikic, Ana; Giga, Vojislav; Beleslin, Branko; Aleksandric, Srdjan; Petrovic, Olga; Ivanovic, Branislava; Trifunovic-Zamaklar, Danijela] Univ Belgrade, Sch Med, Belgrade, Serbia.
C3 Clinical Centre of Serbia; University of Belgrade
RP Jovanovic, I (corresponding author), Univ Clin Ctr Serbia, Clin Cardiol, Visegradska 26, Belgrade 11000, Serbia.
EM ivana170679@gmail.com
RI ; Aleksandric, Srdjan/AAZ-1005-2021
OI Giga, Vojislav/0000-0003-1049-6321; Boskovic,
   Nikola/0000-0001-8987-4190; Aleksandric, Srdjan/0000-0001-6903-4477;
   Tesic, Milorad/0000-0002-3758-3719; Petrovic, Olga/0000-0002-6631-6353
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NR 93
TC 0
Z9 0
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0091-2751
EI 1097-0096
J9 J CLIN ULTRASOUND
JI J. Clin. Ultrasound
PD OCT
PY 2022
VL 50
IS 8
SI SI
BP 1134
EP 1142
DI 10.1002/jcu.23313
PG 9
WC Acoustics; Radiology, Nuclear Medicine & Medical Imaging
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Acoustics; Radiology, Nuclear Medicine & Medical Imaging
GA 5L3PU
UT WOS:000870328100014
PM 36218210
DA 2025-06-11
ER

PT J
AU Heshmati, J
AF Heshmati, Javad
TI Effect of omega-3 fatty acid supplementation on gene expression of
   inflammation, oxidative stress and cardiometabolic parameters:
   Systematic review and meta-analysis
SO JOURNAL OF FUNCTIONAL FOODS
LA English
DT Review
DE Omega-3 FAs; Gene expression; PPAR-gamma; LDLR; IL-1
ID POLYUNSATURATED FATTY-ACIDS; TYPE-2 DIABETIC-PATIENTS; E
   CO-SUPPLEMENTATION; PPAR-GAMMA; FISH-OIL; DOUBLE-BLIND;
   CARDIOVASCULAR-DISEASE; ADIPONECTIN LEVELS; MONONUCLEAR-CELLS; TNF-ALPHA
AB There is growing evidence of the beneficial health effects of omega-3 fatty acid (FAs) supplementation on gene expression of metabolic factors, but a summation of outcomes from randomized controlled trials (RCTs) is lacking. Our aim was to investigate the state of the evidence on the potential impacts of omega-3 FA oral intake on gene expression of factors related to inflammation and oxidative stress (IL-1, IL-8, Sirt-1 and TNF-alpha) and cardiometabolic parameters (LDLR, PPAR-gamma, adiponectin, Lp(a), and GLUT-1). Scopus, Web of Science, MEDLINE, and the Cochrane Central Register of Controlled Trials were searched from inception until December 2020. RCTs which evaluated the effect of oral intake of omega-3 FA on gene expression of cardiometabolic risk factors were included. Data were extracted using STATA software and analyzed using a random effect model. The effect size is given in a standardized mean difference (SMD) and a 95% confidence interval (95% CI). The quality of the included RCTs was assessed by Cochrane tool and almost all studies had a fair quality. Thirteen trials were included in this systematic review. Current analysis indicated that omega-3 FA intake significantly up-regulated the PPAR-gamma (SMD: 1.05; 95% CI: 0.62, 1.48; I2 = 73.9%) and down-regulation of LDLR (SMD: -0.75; 95% CI: -0.38, -0.13; I2 = 77.8%) and IL-1(SMD: -0.89; 95% CI: -1.24, -0.54; I2 = 00.0%). However, these outcomes also indicate that omega-3 FA intake has no significant effect on the gene expression of adiponectin, GLUT-1, Lp(a), IL-8, Sirt-1 and TNF-alpha. This analysis suggests that omega-3 FA intake may improve gene expression of PPAR-gamma, LDLR and IL-1. However, large well-designed, and long-duration RCTs are still required to clarify the effect of omega-3 FA intake on the expression of critical factors related to inflammation, oxidative stress, and cardiometabolic parameters codifying genes.
C1 [Heshmati, Javad] Kermanshah Univ Med Sci, Songhor Hlthcare Ctr, Kermanshah, Iran.
C3 Kermanshah University of Medical Sciences
RP Heshmati, J (corresponding author), Songhor Hlthcare Ctr, Dept Nutr Sci, Songhor, Kermanshah, Iran.
EM Javad.Heshmati@gmail.com
RI heshmati, javad/H-6812-2019
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NR 81
TC 8
Z9 9
U1 1
U2 25
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1756-4646
EI 2214-9414
J9 J FUNCT FOODS
JI J. Funct. Food.
PD OCT
PY 2021
VL 85
AR 104619
DI 10.1016/j.jff.2021.104619
EA JUL 2021
PG 13
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA UD0KI
UT WOS:000686905800010
OA gold
DA 2025-06-11
ER

PT J
AU Contos, MJ
   Sanyal, TJ
AF Contos, MJ
   Sanyal, TJ
TI The clinicopathologic spectrum and management of nonalcoholic fatty
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SO ADVANCES IN ANATOMIC PATHOLOGY
LA English
DT Review
DE nonalcoholic fatty liver disease; nonalcoholic steatohepatitis; fatty
   liver; insulin resistance; diabetes mellitus; obesity
ID INSULIN-RESISTANCE; SYNDROME-X; CRYPTOGENIC CIRRHOSIS; STEATOHEPATITIS
   NASH; GLUCOSE-METABOLISM; GENERAL-POPULATION; HEPATIC STEATOSIS;
   NATURAL-HISTORY; RISK-FACTORS; PREVALENCE
AB Nonalcoholic fatty liver disease (NAFD) comprises a spectrum of conditions characterized by the presence of predominantly macrovesicular fatty change in the liver and the absence of alcohol consumption in amounts considered detrimental to the liver. The histologic spectrum of NAFLD includes fatty liver alone or steatohepatitis (NASH). Nonalcoholic steatohepatitis is associated with increasing fibrosis is sonic cases and may progress to cirrhosis. Nonalcoholic fatty liver disease is often associated with insulin resistance. It is likely that there are one or more additional pathophysiologic defects in those with NASH, rendering them more susceptible to injury from oxidative stress, The clinical and histologic features of NASH are described, and an approach to the diagnosis and treatment of NAFLD is provided.
C1 Virginia Commonwealth Univ, Med Coll Virginia, Dept Pathol, Richmond, VA 23298 USA.
   Virginia Commonwealth Univ, Med Coll Virginia, Dept Internal Med, Div Gastroenterol, Richmond, VA 23298 USA.
C3 Virginia Commonwealth University; Virginia Commonwealth University
RP Virginia Commonwealth Univ, Med Coll Virginia, Dept Pathol, MCV Box 980662, Richmond, VA 23298 USA.
EM mcontos@hsc.vcu.edu
FU NIDDK NIH HHS [DK-02755-02] Funding Source: Medline
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NR 104
TC 59
Z9 66
U1 0
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1072-4109
EI 1533-4031
J9 ADV ANAT PATHOL
JI Adv. Anat. Pathol.
PD JAN
PY 2002
VL 9
IS 1
BP 37
EP 51
DI 10.1097/00125480-200201000-00005
PG 15
WC Pathology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pathology
GA 509JK
UT WOS:000173144500007
PM 11756758
DA 2025-06-11
ER

PT J
AU Fernandes, BS
   Steiner, J
   Bernstein, HG
   Dodd, S
   Pasco, JA
   Dean, OM
   Nardin, P
   Gonçalves, CA
   Berk, M
AF Fernandes, B. S.
   Steiner, J.
   Bernstein, H-G
   Dodd, S.
   Pasco, J. A.
   Dean, O. M.
   Nardin, P.
   Goncalves, C-A
   Berk, M.
TI C-reactive protein is increased in schizophrenia but is not altered by
   antipsychotics: meta-analysis and implications
SO MOLECULAR PSYCHIATRY
LA English
DT Article
ID KYNURENINE AMINOTRANSFERASE II; BIPOLAR DISORDER; NEUROTROPHIC FACTOR;
   METABOLIC SYNDROME; DISEASE RISK; SERUM-LEVELS; TNF-ALPHA; INFLAMMATION;
   ASSOCIATION; MARKERS
AB The inflammatory hypothesis of schizophrenia (SZ) posits that inflammatory processes and neural-immune interactions are involved in its pathogenesis, and may underpin some of its neurobiological correlates. SZ is the psychiatric disorder causing the most severe burden of illness, not just owing to its psychiatric impairment, but also owing to its significant medical comorbidity. C-reactive protein (CRP) is a commonly used biomarker of systemic inflammation worldwide. There are some conflicting results regarding the behaviour of CRP in SZ. The aims of this study were to verify whether peripheral CRP levels are indeed increased in SZ, whether different classes of antipsychotics divergently modulate CRP levels and whether its levels are correlated with positive and negative symptomatology. With that in mind, we performed a meta-analysis of all cross-sectional studies of serum and plasma CRP levels in SZ compared to healthy subjects. In addition, we evaluated longitudinal studies on CRP levels before and after antipsychotic use. Our meta-analyses of CRP in SZ included a total of 26 cross-sectional or longitudinal studies comprising 85 000 participants. CRP levels were moderately increased in persons with SZ regardless of the use of antipsychotics and did not change between the first episode of psychosis and with progression of SZ (g = 0.66, 95% confidence interval (95% CI) 0.43 to 0.88, P < 0.001, 24 between-group comparisons, n = 82 962). The extent of the increase in peripheral CRP levels paralleled the increase in severity of positive symptoms, but was unrelated to the severity of negative symptoms. CRP levels were also aligned with an increased body mass index. Conversely, higher age correlated with a smaller difference in CRP levels between persons with SZ and controls. Furthermore, CRP levels did not increase after initiation of antipsychotic medication notwithstanding whether these were typical or atypical antipsychotics (g = 0.01, 95% CI -0.20 to 0.22, P = 0.803, 8 within-group comparisons, n = 713). In summary, our study provides further evidence of the inflammatory hypothesis of SZ. Whether there is a causal relationship between higher CRP levels and the development of SZ and aggravation of psychotic symptoms, or whether they are solely a marker of systemic low-grade inflammation in SZ, remains to be clarified.
C1 [Fernandes, B. S.; Dodd, S.; Pasco, J. A.; Dean, O. M.; Berk, M.] Deakin Univ, Sch Med, Barwon Hlth, IMPACT Strateg Res Ctr, Geelong, Vic 3217, Australia.
   [Fernandes, B. S.; Nardin, P.; Goncalves, C-A] Univ Fed Rio Grande do Sul, UFRGS, Dept Biochem, Lab Calcium Binding Proteins Cent Nervous Syst, Porto Alegre, RS, Brazil.
   [Steiner, J.; Bernstein, H-G] Univ Magdeburg, Dept Psychiat, D-39106 Magdeburg, Germany.
   [Dodd, S.; Dean, O. M.; Berk, M.] Univ Melbourne, Dept Psychiat & Orygen, Florey Inst Neurosci & Mental Hlth, Natl Ctr Excellence Youth Mental Hlth, Parkville, Vic 3052, Australia.
   [Pasco, J. A.] Univ Melbourne, Dept Med, Northwest Acad Ctr, St Albans, Vic, Australia.
C3 Deakin University; Barwon Health; Universidade Federal do Rio Grande do
   Sul; Otto von Guericke University; University of Melbourne; Florey
   Institute of Neuroscience & Mental Health; Orygen, The National Centre
   of Excellence in Youth Mental Health; University of Melbourne
RP Fernandes, BS (corresponding author), Deakin Univ, Sch Med, Barwon Hlth, IMPACT Strateg Res Ctr, Geelong, Vic 3217, Australia.
EM brisasf@gmail.com
RI Berk, Michael/AGH-9427-2022; Dean, Olivia/ADN-9162-2022; Nardin,
   Patrícia/AEG-5280-2022; Goncalves, Carlos/A-6529-2008; Ackland,
   Julie/C-8607-2012; Fernandes, Brisa/B-6614-2009; Berk,
   Michael/M-7891-2013
OI Fernandes, Brisa/0000-0002-3797-7582; Steiner,
   Johann/0000-0002-2611-2268; Berk, Michael/0000-0002-5554-6946; Nardin,
   Patricia/0000-0003-0719-9369
FU MCTI/CNPQ/Universal from CNPq, Brazil [14/2014461833/2014-0]; NHMRC
   Senior Principal Research Fellowship [1059660]
FX We thank all the authors of the included papers, in particular Drs
   Domenico De Berardis, Nilay Hepgul, Susanne Kraemer, Vanessa Mondelli
   and Jaana Suvisaari, who very kindly provided us with unpublished data
   for our paper. BSF is supported by a scholarship and by a research grant
   MCTI/CNPQ/Universal 14/2014461833/2014-0, both from CNPq, Brazil. MB is
   supported by a NHMRC Senior Principal Research Fellowship 1059660.
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NR 71
TC 252
Z9 260
U1 0
U2 34
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 1359-4184
EI 1476-5578
J9 MOL PSYCHIATR
JI Mol. Psychiatr.
PD APR
PY 2016
VL 21
IS 4
BP 554
EP 564
DI 10.1038/mp.2015.87
PG 11
WC Biochemistry & Molecular Biology; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Neurosciences & Neurology; Psychiatry
GA DG9RM
UT WOS:000372421500015
PM 26169974
DA 2025-06-11
ER

PT J
AU Wei, YM
   Wang, XJ
   Yang, XD
   Wang, CS
   Wang, LL
   Xu, XY
   Zhao, GJ
   Li, B
   Zhu, DM
   Wu, Q
   Shen, YF
AF Wei, Yu-Mei
   Wang, Xi-Jin
   Yang, Xiao-Dong
   Wang, Chuan-Sheng
   Wang, Li-Li
   Xu, Xiao-Ying
   Zhao, Gui-Jun
   Li, Bin
   Zhu, Dao-Min
   Wu, Qi
   Shen, Yi-Feng
TI Safety and effectiveness of lurasidone in the treatment of Chinese
   schizophrenia patients: An interim analysis of post-marketing
   surveillance
SO WORLD JOURNAL OF PSYCHIATRY
LA English
DT Article
DE Lurasidone; Safety; Effectiveness; Surveillance; Schizophrenia; Chinese
ID DOUBLE-BLIND; METABOLIC SYNDROME; ANTIPSYCHOTIC AGENT; POOLED ANALYSIS;
   SHORT-TERM; EFFICACY; PLACEBO; TOLERABILITY; OBESITY; METAANALYSIS
AB BACKGROUNDSchizophrenia is a psychiatric disorder characterized by chronic or recurrent symptoms. Lurasidone was licensed in China in 2019 for the treatment of adult schizophrenia in adults with a maximum dose of 80 mg/d. However, post-market surveillance (PMS) with an adequate sample size is required for further validation of the drug's safety profile and effectiveness. AIMTo conduct PMS in real-world clinical settings and evaluate the safety and effectiveness of lurasidone in the Chinese population. METHODSA prospective, multicenter, open-label, 12-wk surveillance was conducted in mainland China. All patients with schizophrenia from 10 sites who had begun medication with lurasidone between September 2019 and August 2022 were eligible for enrollment. Safety assessments included adverse events (AEs), adverse drug reactions (ADRs), extrapyramidal symptoms (EPS), akathisia, use of EPS drugs, weight gain, and laboratory values as metabolic parameters and the QTc interval. The effectiveness was assessed using the brief psychiatric rating scale (BPRS) from baseline to the end of treatment. RESULTSA total of 965 patients were enrolled in the full analysis set and 894 in the safety set in this interim analysis. The average daily dose was 61.7 +/- 19.08 mg (mean +/- SD) during the treatment. AEs and ADRs were experienced by 101 patients (11.3%) and 78 patients (8.7%), respectively, which were mostly mild. EPS occurred in 25 individuals with a 2.8% incidence, including akathisia in 20 individuals (2.2%). Moreover, 59 patients received drugs for treating EPS during the treatment, with an incidence of 6.6% which dropped to 5.4% at the end of the treatment. The average weight change was 0.20 +/- 2.36 kg (P = 0.01687) with 0.8% of patients showing a weight gain of >= 7% at week 12 compared with that at the baseline. The mean values of metabolic parameters and the QTc interval at baseline and week 12 were within normal ranges. The mean changes in total BPRS scores were-8.9 +/- 9.76 (n = 959),-13.5 +/- 12.29 (n = 959), and-16.8 +/- 13.97 (n = 959) after 2/4, 6/8, and 12 wk, respectively (P < 0.001 for each visit compared with the baseline) using the last-observation-carried-forward method. CONCLUSIONThe interim analysis of the PMS of adult patients with schizophrenia demonstrate the safety and effectiveness of lurasidone in the Chinese population. No new safety or efficacy concerns were identified.
C1 [Wei, Yu-Mei] Shanghai Jiao Tong Univ, Shanghai Clin Res Ctr Mental Hlth, Sch Med, Shanghai 200030, Peoples R China.
   [Wang, Xi-Jin] First Psychiat Hosp Harbin, Dept Psychiat, Harbin 150056, Heilongjiang, Peoples R China.
   [Yang, Xiao-Dong] Shandong Prov Mental Hlth Ctr, Dept Psychiat, Jinan 250014, Shandong, Peoples R China.
   [Wang, Chuan-Sheng] Xinxiang Med Univ, Affiliated Hosp 2, Dept Psychiat, Xinxiang 453002, Henan, Peoples R China.
   [Wang, Li-Li] Tianjin Anding Hosp, Tianjin Mental Hlth Ctr, Dept Psychiat, Tianjin 300222, Peoples R China.
   [Xu, Xiao-Ying] Fifth Peoples Hosp Zigong, Dept Psychiat, Zigong 643020, Sichuan, Peoples R China.
   [Zhao, Gui-Jun] Guangyuan Mental Hlth Ctr, Dept Psychiat, Guangyuan 628001, Guizhou, Peoples R China.
   [Li, Bin] Fujian Energy Gen Hosp, Dept Psychol, Fuzhou 350001, Fujian, Peoples R China.
   [Zhu, Dao-Min] Anhui Med Univ, Affiliated Psychol Hosp, Hefei Peoples Hosp 4, Anhui Mental Hlth Ctr,Dept Sleep Disorders, Hefei 230022, Anhui, Peoples R China.
   [Wu, Qi] Sumitomo Pharm China Co Ltd, Shanghai 200025, Peoples R China.
   [Shen, Yi-Feng] Shanghai Jiao Tong Univ, Shanghai Clin Res Ctr Mental Hlth, Shanghai Key Lab Psychot Disorders, 600 Wanping Nan Rd, Shanghai 200030, Peoples R China.
C3 Shanghai Jiao Tong University; Xinxiang Medical University; Anhui
   Medical University; Shanghai Jiao Tong University
RP Shen, YF (corresponding author), Shanghai Jiao Tong Univ, Shanghai Clin Res Ctr Mental Hlth, Shanghai Key Lab Psychot Disorders, 600 Wanping Nan Rd, Shanghai 200030, Peoples R China.
EM shenyifeng@sina.com
RI 许, 筱颖/ACG-9319-2022
OI SHEN, Yifeng/0000-0002-3298-6682
FU Collaborative Innovation Center Project of Translational Medicine,
   Shanghai Jiaotong University School of Medicine [TM202116PT]; Clinical
   Research Plan of SHDC [SHDC2022CRS032]; Sumitomo Pharmaceuticals
   (Suzhou) Co., Ltd.
FX Supported by Collaborative Innovation Center Project of Translational
   Medicine, Shanghai Jiaotong University School of Medicine, No.
   TM202116PT (2021-2023); Clinical Research Plan of SHDC, No.
   SHDC2022CRS032; and the Sumitomo Pharmaceuticals (Suzhou) Co., Ltd.
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NR 47
TC 4
Z9 5
U1 0
U2 4
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 7041 Koll Center Parkway, Suite 160, PLEASANTON, CA, UNITED STATES
SN 2220-3206
J9 WORLD J PSYCHIATR
JI World J. Psychiatr.
PD NOV 19
PY 2023
VL 13
IS 11
BP 937
EP 948
DI 10.5498/wjp.v13.i11.937
PG 12
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychiatry
GA AH7E7
UT WOS:001117631300012
PM 38073894
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Sodagar, S
   Ghane, Y
   Heidari, A
   Heidari, N
   Khodadust, E
   Ahmadi, SAY
   Seirafianpour, F
   Baradaran, H
   Goodarzi, A
AF Sodagar, Sogand
   Ghane, Yekta
   Heidari, Amirhossein
   Heidari, Nazila
   Khodadust, Elaheh
   Ahmadi, Seyyed Amir Yasin
   Seirafianpour, Farnoosh
   Baradaran, Hamid
   Goodarzi, Azadeh
TI Association between metabolic syndrome and prevalent skin diseases: A
   systematic review and meta-analysis of case-control studies
SO HEALTH SCIENCE REPORTS
LA English
DT Review
DE androgenic alopecia; dermatology; hidradenitis suppurativa; insulin
   resistance; lichen planus; metabolic syndrome; psoriasis; rosacea;
   seborrheic dermatitis; skin disease; vitiligo
ID CARDIOVASCULAR RISK-FACTORS; SEMIURBAN MAHARASHTRIAN POPULATION; ONSET
   ANDROGENETIC ALOPECIA; PSORIATIC PATIENTS; LICHEN-PLANUS; COMORBIDITIES;
   SEVERITY; DURATION; ROSACEA; NCEP
AB Background and AimMetabolic syndrome (MetS) is a well-known noncommunicable disease that plays a significant role in emerging other chronic disorders and following complications. MetS is also involved in the pathophysiology of numerous dermatological diseases. We aim to evaluate the association of MetS with the most prevalent dermatological diseases.MethodsA systematic search was carried out on PubMed, Science Direct, Web of Science, Cochrane, as well as the Google Scholar search engine. Only English case-control studies regarding MetS and any skin disease from the beginning of 2010 up to November 15, 2022, were selected. The study was conducted based on the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA).ResultsA total of 37 studies (13,830 participants) met the inclusion criteria. According to our result, patients with psoriasis, hidradenitis suppurativa (HS), vitiligo, androgenetic alopecia (AGA), and lichen planus (LP) have a higher chance of having MetS compared to the general population. Furthermore, people with seborrheic dermatitis (SED) and rosacea are more prone to insulin resistance, high blood pressure (BP), and higher blood lipids. After pooling data, the meta-analysis revealed a significant association between MetS and skin diseases (pooled odds ratio [OR]: 3.28, 95% confidence interval: 2.62-4.10). Concerning the type of disease, MetS has been correlated with AGA (OR: 11.86), HS (OR: 4.46), LP (OR: 3.79), and SED (OR: 2.45). Psoriasis also showed a significant association but with high heterogeneity (OR: 2.89). Moreover, skin diseases and MetS are strongly associated in Spain (OR: 5.25) and Thailand (OR: 11.86). Regarding the metaregression model, the effect size was reduced with increasing age (OR: 0.965), while the size increased with AGA (OR: 3.064).ConclusionsMetS is closely associated with skin complications. Dermatologists and other multidisciplinary teams should be cautious while treating these patients to prevent severe complications resulting from MetS.
   Metabolic syndrome (MetS) is one of the major scourges among noncommunicable diseases, with a prevalence of 25%-33% of all individuals suffering from this condition globally.Skin manifestations can occur in the case of any pathophysiological disorder that results in a loss of metabolic control or involves inflammatory factors such as interleukins, TNF, and oxidative stress.Patients with psoriasis, vitiligo, hidradenitis suppurativa, and lichen planus are more likely to suffer from MetS compared to the general population.People suffering from seborrheic dermatitis and rosacea are more prone to insulin resistance, high blood pressure, and higher blood lipids.The relationship between discoid lupus, acne, atopic dermatitis, alopecia areata, and blistering diseases like pemphigus vulgaris has not been examined yet in case-control studies; however, there has been some evidence of relationships in the field of MetS components, including insulin resistance.
C1 [Sodagar, Sogand; Heidari, Nazila; Khodadust, Elaheh] Iran Univ Med Sci, Sch Med, Tehran, Iran.
   [Ghane, Yekta] Univ Tehran Med Sci, Sch Med, Tehran, Iran.
   [Heidari, Amirhossein] Islamic Azad Univ, Fac Med, Tehran Med Sci, Tehran, Iran.
   [Ahmadi, Seyyed Amir Yasin] Iran Univ Med Sci, Prevent Med & Publ Hlth Res Ctr, Tehran, Iran.
   [Seirafianpour, Farnoosh] Iran Univ Med Sci IUMS, Razi Drug Res Ctr, Tehran, Iran.
   [Baradaran, Hamid] Iran Univ Med Sci, Inst Endocrinol & Metab, Tehran, Iran.
   [Baradaran, Hamid] Univ Aberdeen, Inst Appl Hlth Sci, Aging Clin & Expt Res Team, Aberdeen, Scotland.
   [Goodarzi, Azadeh] Iran Univ Med Sci, Sch Med, Rasool Akram Med Complex Clin Res Dev Ctr RCRDC, Dept Dermatol, Tehran, Iran.
   [Goodarzi, Azadeh] Iran Univ Med Sci, Sch Med, Rasool Akram Med Complex Clin Res Dev Ctr RCRDC, Dermatol, Sattarkhan Ave, Tehran, Iran.
C3 Iran University of Medical Sciences; Tehran University of Medical
   Sciences; Islamic Azad University; Iran University of Medical Sciences;
   Iran University of Medical Sciences; Iran University of Medical
   Sciences; University of Aberdeen; Iran University of Medical Sciences;
   Iran University of Medical Sciences
RP Goodarzi, A (corresponding author), Iran Univ Med Sci, Sch Med, Rasool Akram Med Complex Clin Res Dev Ctr RCRDC, Dermatol, Sattarkhan Ave, Tehran, Iran.
EM Azadeh_goodarzi1984@yahoo.com
RI seirafianpour, farnoosh/AAT-3885-2020; Baradaran, Hamid/N-2577-2019;
   goodarzi, Azadeh/Z-1736-2018; Ahmadi, Seyyed Amir Yasin/E-9575-2017;
   Heidari, Amirhossein/JMQ-2187-2023; Baradaran, Hamid Reza/C-1556-2017
OI Heidari, Amirhossein/0000-0003-4327-8814; Baradaran, Hamid
   Reza/0000-0002-5070-5864; Ghane, Yekta/0000-0002-7309-4066;
   Seirafianpour, Farnoosh/0000-0003-3794-6206; Heidari,
   Nazila/0000-0001-7259-4926; Khodadoust, Elaheh/0009-0003-4551-5139;
   goodarzi, azadeh/0000-0002-1249-4429
FU The authors would like to express their gratitude to the authorities of
   Rasool Akram Medical Complex Clinical Research Development Center
   (RCRDC) for their technical and editorial assistance.
FX The authors would like to express their gratitude to the authorities of
   Rasool Akram Medical Complex Clinical Research Development Center
   (RCRDC) for their technical and editorial assistance.
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NR 63
TC 15
Z9 15
U1 0
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
EI 2398-8835
J9 HEALTH SCI REP-US
JI Health Sci. Rep.
PD SEP
PY 2023
VL 6
IS 9
AR e1576
DI 10.1002/hsr2.1576
PG 19
WC Public, Environmental & Occupational Health; Medicine, General &
   Internal
WE Emerging Sources Citation Index (ESCI)
SC Public, Environmental & Occupational Health; General & Internal Medicine
GA T1NE5
UT WOS:001075714700001
PM 37752973
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Gabrick, K
   Alperovich, M
   Chouari, F
   Mets, EJ
   Reinhart, M
   Dinis, J
   Avraham, T
AF Gabrick, Kyle
   Alperovich, Michael
   Chouari, Fouad
   Mets, Elbert J.
   Reinhart, Manuel
   Dinis, Jacob
   Avraham, Tomer
TI Breast reconstruction patterns and outcomes in academic and community
   practices within a single institution
SO BREAST JOURNAL
LA English
DT Article
DE academic plastic surgery; breast reconstruction; community-based plastic
   surgery; outcomes
ID PSYCHOLOGICAL RESPONSE; CARDIOMETABOLIC RISK; SMOKING-CESSATION;
   SCHIZOPHRENIA; MASTECTOMY; CANCER; SURVIVAL; COMPLICATIONS;
   METAANALYSIS; DEPRESSION
AB Breast reconstruction is a common procedure that is performed in both community and academic settings. At Yale-New Haven Hospital (YNHH), both academic (AP) and community-based (CP) plastic surgeons perform breast reconstructions. We aim to compare practice patterns in breast reconstruction between two practice environments within a single institution. A retrospective chart review of all breast reconstructions at YNHH between 2013 and 2018 was performed. Data collected included demographics, preoperative history, and postoperative outcomes. Results were further subdivided by practice setting. A total of 1045 patients (1683 breasts) underwent breast reconstruction during the study period. About 52.8% were performed by AP while 47.2% were performed by CP. CP had higher rates of autologous reconstruction (P < .001) and nipple-sparing mastectomy (P < .0001). Age and BMI were similar between the cohorts. However, patients cared for by AP had 2.6% increased prevalence of diabetes (P = .064), 5.5% greater prevalence of psychiatric diagnoses (P = .004), and 7.1% higher open abdominal surgery rates (P < .001). Outcomes were similar between the groups except for higher infection rates (P = .027) and explant rates (P = .003) in the CP cohort. When evaluating insurance status, the AP cohort had 30.5% fewer patients with commercial insurance, 16.7% more patients with Medicaid and 6.1% more patients with Medicare (P < .001). Within our institution, academic and community-based plastic surgeons perform breast reconstruction with overall similar complication rates. Patients treated by AP have a higher rate of preoperative medical and psychiatric comorbidities. Patients treated by CP have higher rates of infection and implant explant. AP plastic surgeons care for a significantly higher rate of Medicare and Medicaid patients with proportionally fewer patients with commercial insurance.
C1 [Gabrick, Kyle; Alperovich, Michael; Chouari, Fouad; Mets, Elbert J.; Reinhart, Manuel; Dinis, Jacob; Avraham, Tomer] Yale Sch Med, Dept Surg, Sect Plast & Reconstruct Surg, 330 Cedar St,Boardman Bldg,3rd Floor, New Haven, CT 06510 USA.
C3 Yale University
RP Avraham, T (corresponding author), Yale Sch Med, Dept Surg, Sect Plast & Reconstruct Surg, 330 Cedar St,Boardman Bldg,3rd Floor, New Haven, CT 06510 USA.
EM Tomer.avraham@yale.edu
OI Mets, Elbert/0000-0002-0690-4575
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NR 33
TC 2
Z9 2
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1075-122X
EI 1524-4741
J9 BREAST J
JI Breast J.
PD MAY
PY 2020
VL 26
IS 5
BP 924
EP 930
DI 10.1111/tbj.13693
EA DEC 2019
PG 7
WC Oncology; Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Oncology; Obstetrics & Gynecology
GA LP9ZN
UT WOS:000501456500001
PM 31788914
OA gold
DA 2025-06-11
ER

PT J
AU Courel-Ibáñez, J
   Pallarés, JG
   Navarro, RM
   Guillén, ES
   Cava, AM
   Pay, AS
   Romero, AB
   Conesa, SG
AF Courel-Ibanez, Javier
   Pallares, Jesus G.
   Moran Navarro, Ricardo
   Saura Guillen, Elena
   Martinez Cava, Alejandro
   Sanchez Pay, Alejandro
   Buendia Romero, Angel
   Garcia Conesa, Silverio
CA HEAL Study Grp
TI Effects of β-hydroxy-β-methylbutyrate (HMB) supplementation in addition
   to multicomponent exercise in adults older than 70years living in
   nursing homes, a cluster randomized placebo-controlled trial: the HEAL
   study protocol
SO BMC GERIATRICS
LA English
DT Article
DE Healthy ageing; Physical activity; Physical fitness; Falls; Dynapenia
ID PHYSICAL PERFORMANCE; DOUBLE-BLIND; VITAMIN-D; SARCOPENIA; LEUCINE;
   FRAILTY; PEOPLE; RISK; INTERVENTIONS; PREVALENCE
AB BackgroundEvidence supports the fact that multicomponent exercise and HMB supplementation are, separately, effective in improving older adult's health and palliate functional metabolic diseases in older people. However, the true effect of HMB supplementation combined with a tailored exercise program in frail older adults is still unknown. Thus, the aim of the HEAL (HMB+Exercise=Adults Living longer) study is to assess the effects of the combination of a daily multicomponent exercise and resistance training (VIVIFRAIL program) intervention in addition to HMB supplementation on older adults' health.Methods/designA 24-week cluster randomized, double-blind, placebo-controlled study will be conducted on 104 adults >= 70years. Nursing homes will be randomized to either of four groups: Ex-HMB (exercise intervention with HMB), Ex-Plac (exercise intervention with placebo), NoEx-HMB (no exercise intervention with HMB), and Controls (No exercise and no HMB). Intervention groups which include exercise will complete the individualized multicomponent (strength, balance and cardiovascular exercises) training program VIVIFRAIL. Intervention groups which include HMB supplementation will receive a 3g/daily dose of free acid HMB in powder form. The primary outcome measure is the functional capacity. Secondary outcome measures are muscle strength and power, frailty and fall risk, body composition, biochemical analyses and cardiometabolic risk factor, disability and comorbidity, cognitive function and depression.DiscussionThe findings of the HEAL study will help professionals from public health systems to identify cost-effective and innovative actions to improve older people's health and quality of life, and endorse exercise practice in older adults and people living in nursing homes.Trial registrationNCT03827499; Date of registration: 01/02/2019.
C1 [Courel-Ibanez, Javier; Pallares, Jesus G.] Univ Murcia, Fac Sport Sci, Human Performance & Sports Sci Lab, Calle Argentina 19, Murcia 30720, Spain.
   [Courel-Ibanez, Javier; Pallares, Jesus G.; Moran Navarro, Ricardo; Martinez Cava, Alejandro; Sanchez Pay, Alejandro] Univ Murcia, Fac Sport Sci, Dept Phys Activ & Sport, Human Performance & Sports Sci Lab, Murcia, Spain.
   [Saura Guillen, Elena] Univ Hosp Virgen Arrixaca, Endocrinol & Nutr Serv, Murcia, Spain.
   [Buendia Romero, Angel; Garcia Conesa, Silverio] Univ Murcia, Fac Sport Sci, Murcia, Spain.
C3 University of Murcia; University of Murcia; Hospital Clinico
   Universitario Virgen de la Arrixaca; University of Murcia
RP Courel-Ibáñez, J (corresponding author), Univ Murcia, Fac Sport Sci, Human Performance & Sports Sci Lab, Calle Argentina 19, Murcia 30720, Spain.
EM Javier.courel.ibanez@gmail.com
RI Pallarés, Jesús/J-3054-2016; Sánchez-Pay, Alejandro/AAD-6592-2021;
   Buendía-Romero, Ángel/LOR-7330-2024; Moran-Navarro,
   Ricardo/KOZ-9689-2024; Courel-Ibanez, Javier/I-4264-2015
OI Moran-Navarro, Ricardo/0000-0002-0991-9203; Courel-Ibanez,
   Javier/0000-0003-2446-1875; Garcia Conesa, Silverio/0000-0001-5445-5236;
   Sanchez-Pay, Alejandro/0000-0003-1600-4172
FU Autonomous Community of the Region of Murcia, Regional Program for the
   Promotion of Scientific and Technical Research; Seneca Foundation-Agency
   of Science and Technology, Region of Murcia [20872/PI/18]
FX This protocol has been peer-reviewed and funded by the Autonomous
   Community of the Region of Murcia, Regional Program for the Promotion of
   Scientific and Technical Research (Action Plan 2018), Seneca
   Foundation-Agency of Science and Technology, Region of Murcia (ID:
   20872/PI/18).
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NR 61
TC 11
Z9 13
U1 1
U2 33
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2318
J9 BMC GERIATR
JI BMC Geriatr.
PD JUL 5
PY 2019
VL 19
AR 188
DI 10.1186/s12877-019-1200-5
PG 10
WC Geriatrics & Gerontology; Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA IH5SB
UT WOS:000474552700004
PM 31277595
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Guillet, C
   Seeli, C
   Nina, M
   Maul, LV
   Maul, JT
AF Guillet, Carole
   Seeli, Corsin
   Nina, Meienberger
   Maul, Lara Valeska
   Maul, Julia-Tatjana
TI The impact of gender and sex in psoriasis: What to be aware of when
   treating women with psoriasis
SO INTERNATIONAL JOURNAL OF WOMENS DERMATOLOGY
LA English
DT Review
DE Differences; gender; pregnancy; psoriasis
ID IMMUNE-MEDIATED DISEASES; T-CELL PARADIGM; PSYCHOLOGICAL DISTRESS;
   SYSTEMIC TREATMENT; TACROLIMUS OINTMENT; CERTOLIZUMAB PEGOL;
   PLACENTAL-TRANSFER; METABOLIC SYNDROME; NATIONAL-HEALTH; GENOME-WIDE
AB Background:Psoriasis is a common chronic inflammatory skin disease with an exceptionally high burden for women.Objective:Sex-dependent differences in disease manifestation, severity, treatment choices, subjective disease perception, and the impact on quality of life and risk factors are described and comprehensively discussed.Methods:A literature search was conducted using MEDLINE (PubMed) and the Cochrane Library for systematic reviews to investigate the challenges in treating women with psoriasis.Results and conclusions:The incidence, prevalence, and manifestation of psoriasis of the skin are similar between different sexes. Genetic and environmental factors such as obesity and metabolic syndrome are risk factors and are not equally relevant or pronounced in women and men. Overall, women have a lower disease severity measured by the Psoriasis Area Severity Index, which is associated with a higher impairment of their life quality measured by the Dermatology Life Quality Index compared with men. In addition, women with psoriasis are more likely to have depression than men. Hormonal factors affect psoriasis, with a correlation of high estrogen levels and improvement of psoriasis. Data regarding differences in prescribing patterns of systemic treatments and the severity of psoriasis are not entirely consistent. Registry studies show that men tend to have more severe psoriasis and, in some cases, are prescribed systemic therapies more frequently. Women tend to respond better to systemic treatments and to experience more adverse events. Treatment options are the same for both sexes, except during pregnancy and lactation. Various treatment options are contraindicated due to fear of fetal or neonate harm and lack of data. Topical steroids can be prescribed with a high degree of safety during pregnancy. For other topical therapies (calcineurin inhibitors and vitamin D analogs), no studies of adverse effects in pregnancy are available, and safety data mainly stem from studies examining effects after systemic administration. Antitumor necrosis factor monoclonal antibodies (except for certolizumab pegol) have been associated with a possible increased risk of preterm birth, low gestational age, and cesarean deliveries. Prospective data on the safety of biologics other than antitumor necrosis factor-alpha antibodies to accurately assess whether novel biologics (eg, anti-interleukin 17, 12/23, 23) can be used for systemic therapy in pregnancy are lacking or currently being conducted.
C1 [Guillet, Carole; Nina, Meienberger; Maul, Julia-Tatjana] Univ Hosp Zurich, Dept Dermatol, Zurich, Switzerland.
   [Guillet, Carole; Nina, Meienberger; Maul, Julia-Tatjana] Univ Zurich, Fac Med, Zurich, Switzerland.
   [Seeli, Corsin] Hochgebirgsklin Davos AG, Dept Dermatol, Davos, Switzerland.
   [Maul, Lara Valeska] Univ Hosp Basel, Dept Dermatol, Basel, Switzerland.
C3 University of Zurich; University Zurich Hospital; University of Zurich;
   University of Geneva; University of Basel
RP Maul, JT (corresponding author), Univ Hosp Zurich, Dept Dermatol, Zurich, Switzerland.; Maul, JT (corresponding author), Univ Zurich, Fac Med, Zurich, Switzerland.
EM Julia-tatjana.maul@usz.ch
RI Maul, Julia-Tatjana/HDM-1043-2022
OI Maul, Julia-Tatjana/0000-0002-9914-1545
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NR 152
TC 39
Z9 41
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 2352-6475
J9 INT J WOMEN DERMATOL
JI Int. J. Womens Dermatol.
PD JUN
PY 2022
VL 8
IS 2
AR e010
DI 10.1097/JW9.0000000000000010
PG 10
WC Dermatology
WE Emerging Sources Citation Index (ESCI)
SC Dermatology
GA P7D8Q
UT WOS:001379477700001
PM 35619672
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Romanelli, RJ
   Sudat, S
   Huang, QW
   Ma, J
   Venditti, EM
   Greenwood, DA
   Pressman, AR
   Azar, KMJ
AF Romanelli, Robert J.
   Sudat, Sylvia
   Huang, Qiwen
   Ma, Jun
   Venditti, Elizabeth M.
   Greenwood, Deborah A.
   Pressman, Alice R.
   Azar, Kristen M. J.
TI Short-term weight trajectories and long-term weight outcomes from a
   lifestyle intervention in real-world clinical practice
SO TRANSLATIONAL BEHAVIORAL MEDICINE
LA English
DT Article
DE Behavioral lifestyle program; Weight loss; real world; Electronic health
   records
ID DIABETES PREVENTION PROGRAM; UNITED-STATES; LOSS PATTERNS; RISK-FACTORS;
   TASK-FORCE; COMMUNITY; OBESITY; DEPRESSION; MANAGEMENT; METAANALYSIS
AB Centers for Disease Control and Prevention aligned lifestyle change programs are effective in promoting weight loss among those with elevated cardiometabolic risk; yet, variability in weight outcomes among participants is high. Little is known about heterogeneity of short-term weight changes among participants in real-world clinical practice. We sought to identify short-term weight trajectory clusters among lifestyle change program participants in real-world clinical practice and to examine the relationship between cluster membership and long-term weight outcomes. We identified participants from the electronic health records (2010-2017) with weight measured <= 30 days prior to program initiation (baseline) and in four intervals (3-week segments) in the 12 weeks after baseline. Clustering analysis was performed to identify distinct trajectories in percent weight change over 12 weeks. Cluster-specific differences in weight change at 12 and 52 weeks were assessed. Among 1,148 participants, across 18 clinic sites, three clusters were identified: minimal-to-no weight loss (MWL), delayed-minimal weight loss (DWL), and steadymoderate weight loss (SWL), corresponding to mean weight changes of 0.4%, -2.3%, and -4.8% at 12 weeks follow-up, respectively. Mean weight changes were 0.4%, -1.8%, and -5.1% for MWL, DWL, and SWL clusters, respectively, at 52 weeks follow-up, which correlated in direction and magnitude with short-term weight changes. Clustering analysis reveals heterogeneous, short-term weight trajectories among lifestyle change program participants in real-world clinical practice. Given the relationship between the magnitudes of short- and longterm weight change, individual participant weight trajectories may be useful in identifying potential non-responders in need of adjunctive or alternative therapy.
C1 [Romanelli, Robert J.; Huang, Qiwen] Palo Alto Med Fdn Res Inst, Ctr Hlth Syst Res, Sutter Hlth, Palo Alto, CA 94301 USA.
   [Sudat, Sylvia; Pressman, Alice R.; Azar, Kristen M. J.] Sutter Hlth, Div Res Dev & Disseminat, Ctr Hlth Syst Res, Walnut Creek, CA 94596 USA.
   [Ma, Jun] Univ Illinois, Inst Hlth Res & Policy, Dept Med, Chicago, IL 60637 USA.
   [Ma, Jun] Univ Illinois, Ctr Hlth Behav Res, Chicago, IL 60637 USA.
   [Venditti, Elizabeth M.] Univ Pittsburgh, Dept Psychiat, Pittsburgh, PA 15213 USA.
C3 Palo Alto Medical Foundation Research Institute; University of Illinois
   System; University of Illinois Chicago; University of Illinois Chicago
   Hospital; University of Illinois System; University of Illinois Chicago;
   University of Illinois Chicago Hospital; Pennsylvania Commonwealth
   System of Higher Education (PCSHE); University of Pittsburgh
RP Romanelli, RJ (corresponding author), Palo Alto Med Fdn Res Inst, Ctr Hlth Syst Res, Sutter Hlth, Palo Alto, CA 94301 USA.
EM romanerj1@sutterhealth.org
RI Venditti, Elizabeth/E-4732-2018
OI Romanelli, Robert/0009-0001-8244-1939
FU National Institute of Diabetes and Digestive and Kidney Diseases of the
   National Institutes of Health [R18DK110739]
FX Research reported in this publication was supported by the National
   Institute of Diabetes and Digestive and Kidney Diseases of the National
   Institutes of Health under Award Number R18DK110739. The content is
   solely the responsibility of the authors and does not necessarily
   represent the official views of the National Institutes of Health, nor
   did this sponsor have any involvement in creation or submission of this
   report.
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NR 41
TC 7
Z9 7
U1 0
U2 7
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1869-6716
EI 1613-9860
J9 TRANSL BEHAV MED
JI Transl. Behav. Med.
PD DEC
PY 2020
VL 10
IS 6
SI SI
BP 1458
EP 1471
DI 10.1093/tbm/ibz118
PG 14
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA PY7CM
UT WOS:000612199100023
PM 31369678
OA Green Published
DA 2025-06-11
ER

PT J
AU Chitturi, S
   Farrell, GC
AF Chitturi, S
   Farrell, GC
TI Etiopathogenesis of nonalcoholic steatohepatitis
SO SEMINARS IN LIVER DISEASE
LA English
DT Review
DE nonalcoholic steatohepatitis; pathogenesis; etiology
ID FATTY LIVER HEPATITIS; NON-ALCOHOLIC STEATOHEPATITIS; ACTIVATED
   RECEPTOR-ALPHA; NECROSIS-FACTOR-ALPHA; ACYL-COA OXIDASE;
   JEJUNOILEAL-BYPASS; LIPID-PEROXIDATION; AMIODARONE HEPATOTOXICITY;
   CRYPTOGENIC CIRRHOSIS; CYTOCHROME-P450 2E1
AB The definable causes of nonalcoholic steatohepatitis (NASH) include jejunoileal bypass surgery (JIB), other causes of rapid and profound weight loss in obese subjects, total parenteral nutrition, drugs, industrial toxins, copper toxicity, and disorders characterized by extreme insulin resistance. However, the etiopathogenesis in most cases of NASH appears multifactorial. Obesity, type 2 diabetes, and hypertriglyceridemia are often associated with hepatic steatosis, and although this does not invariably lead to NASH, the fatty liver is vulnerable to hepatocellular injury initiated by reactive oxygen species (ROS). It is critical to understand not only the triggers for hepatitis (injury and inflammation) in NASH but also how this is perpetuated as chronic liver disease. The present focus is on whether the biochemical processes that generate oxidative stress lead to hepatocyte injury and secondary recruitment of inflammation or whether inflammation is the primary mediator of liver cell injury. Insulin resistance is a reproducible pathogenic factor in NASH. It favors accumulation of free fatty acids in the liver and predisposes to oxidative stress by stimulating microsomal lipid peroxidases and by the direct effects of high insulin levels in decreasing mitochondrial beta -oxidation. CYP2E1 is normally suppressed by insulin but is invariably increased in the livers of patients with NASH. In rodent dietary models of steatohepatitis, CYP2E1 is the catalyst of microsomal lipid peroxidation, while in Cyp 2e1 nullizygous mice, CYP4A proteins are induced and function as alternative microsomal lipid peroxidases. Other studies implicate activation of peroxisome proliferator-activated receptor-alpha (PPAR alpha) as leading to NASH; PPAR alpha is a transcription factor that governs both microsomal (via CYP4A) and peroxisomal (beta -oxidation) pathways of lipid oxidation and ultimately production of ROS. Increased lipid peroxidation is a crucial difference between the livers of rodents with experimental NASH and those of ob/ob genetically obese mice that have uncomplicated steatosis. Administration of endotoxin, through the release of tumor necrosis factor-alpha (TNF-alpha), provokes liver inflammation with hepatocyte injury in the steatotic liver. This may be particularly relevant in JIB and has been suggested as a pathogenic mechanism in primary NASH. It has been proposed that inheriting one or more copies of the hemochromatosis gene, C282Y, promotes fibrotic progression in NASH because of increased hepatic iron deposition, but recent studies have failed to confirm this. The relationship between the severity of hepatitis in NASH and progression to cirrhosis implies that products of the inflammatory infiltrate play a role in fibrogenesis. In summary, NASH can be regarded as the hepatic consequence of the metabolic syndrome (or syndrome X). Attention should now shift from steatosis, a generally benign process that is less evident in the advanced stages of cirrhosis, to the mechanisms for hepatocellular injury, inflammation, and hepatic fibrosis. In particular, the genetic, molecular, and cellular factors that ordain and moderate fibrosis in the context of steatohepatitis will be of greatest relevance to effective therapy and clinical outcome.
C1 Univ Sydney, Storr Liver Unit, Westmead Millennium Inst, Westmead Hosp, Westmead, NSW 2145, Australia.
C3 NSW Health; Westmead Hospital; University of Sydney; Westmead Institute
   for Medical Research
RP Univ Sydney, Storr Liver Unit, Westmead Millennium Inst, Westmead Hosp, Westmead, NSW 2145, Australia.
EM geoff_farrell@wmi.usyd.edu.au
OI Chitturi, Shivakumar/0000-0002-2367-9859
FU NIDDK NIH HHS [1R01DK562401-01] Funding Source: Medline
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NR 124
TC 506
Z9 554
U1 2
U2 58
PU THIEME MEDICAL PUBL INC
PI NEW YORK
PA 333 SEVENTH AVE, NEW YORK, NY 10001 USA
SN 0272-8087
EI 1098-8971
J9 SEMIN LIVER DIS
JI Semin. Liver Dis.
PY 2001
VL 21
IS 1
BP 27
EP 41
DI 10.1055/s-2001-12927
PG 15
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 416LB
UT WOS:000167781000004
PM 11296694
DA 2025-06-11
ER

PT J
AU Sui, ZG
   Song, XY
   Wu, YJ
   Hou, R
   Liu, JH
   Zhao, BF
   Liang, Z
   Chen, JP
   Zhang, LH
   Zhang, YK
AF Sui, Zhigang
   Song, Xiaoyao
   Wu, Yujie
   Hou, Rui
   Liu, Jianhui
   Zhao, Baofeng
   Liang, Zhen
   Chen, Jiping
   Zhang, Lihua
   Zhang, Yukui
TI The cytotoxicity of PM2.5 and its effect on the secretome of
   normal human bronchial epithelial cells
SO ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
LA English
DT Article
DE Secretome; Proteomic analysis; PM2.5; Cytotoxicity; Apoptosis;
   Extracellular matrix
ID FINE PARTICULATE MATTER; OXIDATIVE STRESS; APOPTOSIS; ACTIVATION;
   EXPOSURE; REGULATOR; RESPONSES; BURDEN; ARREST; TARGET
AB Exposure to airborne fine particulate matter (PM2.5) induced various adverse health effects, such as metabolic syndrome, systemic inflammation, and respiratory disease. Many works have studied the effects of PM2.5 exposure on cells through intracellular proteomics analyses. However, changes of the extracellular proteome under PM2.5 exposure and its correlation with PM2.5-induced cytotoxicity still remain unclear. Herein, the cytotoxicity of PM2.5 on normal human bronchial epithelia cells (BEAS-2B cells) was evaluated, and the secretome profile of BEAS-2B cells before and after PM2.5 exposure was investigated. A total of 83 proteins (58 upregulated and 25 downregulated) were differentially expressed in extracellular space after PM2.5 treatment. Notably, we found that PM2.5 promoted the release of several pro-apoptotic factors and induced dysregulated secretion of extracellular matrix (ECM) constituents, showing that the abnormal extracellular environment attributed to PM2.5-induced cell damage. This study provided a secretome data for the deep understanding of the molecular mechanism underlying PM2.5-caused human bronchial epithelia cell damage.
C1 [Sui, Zhigang; Wu, Yujie; Hou, Rui; Liu, Jianhui; Zhao, Baofeng; Liang, Zhen; Zhang, Lihua; Zhang, Yukui] Chinese Acad Sci, Natl Chromatog R&A Ctr, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, 457 Zhongshan Rd, Dalian 116023, Peoples R China.
   [Song, Xiaoyao; Chen, Jiping] Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Environm Assessment & Anal Grp, Dalian 116023, Peoples R China.
   [Wu, Yujie] Dalian Univ Technol, Zhang Dayu Sch Chem, Dalian 116024, Peoples R China.
C3 Chinese Academy of Sciences; Dalian Institute of Chemical Physics, CAS;
   Chinese Academy of Sciences; Dalian Institute of Chemical Physics, CAS;
   Dalian University of Technology
RP Zhang, LH (corresponding author), Chinese Acad Sci, Natl Chromatog R&A Ctr, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, 457 Zhongshan Rd, Dalian 116023, Peoples R China.
EM lihuazhang@dicp.ac.cn
RI Liu, Jianhui/ISV-5494-2023; Wu, Yujie/C-3510-2012; Li,
   Xin/AAW-2791-2020; Hou, Rui/JXX-9645-2024
OI chen, jiping/0000-0003-0553-7811
FU National Key Research and Development Program of China [2017YFA0505003];
   National Natural Science Foundation [21775149, 91543201, 21806165,
   21725506]
FX This work was supported by National Key Research and Development Program
   of China (Grant 2017YFA0505003) and National Natural Science Foundation
   (Grants 21775149, 91543201, 21806165, and 21725506).
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NR 61
TC 6
Z9 6
U1 4
U2 48
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0944-1344
EI 1614-7499
J9 ENVIRON SCI POLLUT R
JI Environ. Sci. Pollut. Res.
PD OCT
PY 2022
VL 29
IS 50
BP 75966
EP 75977
DI 10.1007/s11356-022-20726-9
EA JUN 2022
PG 12
WC Environmental Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology
GA 5F2WZ
UT WOS:000805915700002
PM 35665889
DA 2025-06-11
ER

PT J
AU Tiwari, S
   Saoji, AA
   Madle, K
   Sapkota, N
   Shashikiran, HC
   Shetty, P
AF Tiwari, Sagun
   Saoji, Apar Avinash
   Madle, Kshamashree
   Sapkota, Namrata
   Shashikiran, H. C.
   Shetty, Prashanth
TI Naturopathy and Yoga for improving quality of life in Pemphigus
   vulgaris and managing co-morbid type 2 diabetes: A case report
SO JOURNAL OF AYURVEDA AND INTEGRATIVE MEDICINE
LA English
DT Article
DE Autoimmunity; Dermatology; Integrative medicine; Naturopathy; Pemphigus
   vulgaris; Yoga
ID MANAGEMENT; MECHANISM; STRESS; INDEX
AB A 57 years old male patient was admitted to an inpatient Naturopathy and Yoga (N & Y) hospital, diag- nosed with pemphigus vulgaris (PV) for one year and co-morbid type 2 diabetes (T2DM) for 10 years, associated with poor quality of life (QoL). He was administered N & Y therapies for 10 days, along with conventional medicines. There was improved QoL and reduced dosage of insulin, along with reduction in body weight. These changes were sustained and improved further during the 60-day follow-up period. Although there was no improvement in the skin lesions, the improvement in QoL indicate a possible role of N & Y in management of PV and T2DM. This case report also warrants further studies for N & Y in the management of dermatological conditions as well as metabolic syndrome. (C) 2020 The Authors. Published by Elsevier B.V. on behalf of Institute of Transdisciplinary Health Sciences and Technology and World Ayurveda Foundation. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
C1 [Tiwari, Sagun; Sapkota, Namrata; Shashikiran, H. C.; Shetty, Prashanth] Sri Dharmasthala Manjunatheswara Coll Naturopathy, Ujire, India.
   [Saoji, Apar Avinash; Madle, Kshamashree] Swami Vivekananda Yoga Anusnadhana Samthana, Div Yoga & Life Sci, Sch Yoga & Naturopath Med, Bangalore, Karnataka, India.
RP Saoji, AA (corresponding author), Swami Vivekananda Yoga Anusnadhana Samthana, Div Yoga & Life Sci, Sch Yoga & Naturopath Med, Bangalore, Karnataka, India.
EM aparsaoji@gmail.com
RI Saoji, Apar/I-8279-2019; TIWARI, SAGUN/GPK-5401-2022
OI Saoji, Apar Avinash/0000-0002-0710-9004
CR Funk JL, 2006, ARTHRITIS RHEUM-US, V54, P3452, DOI 10.1002/art.22180
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NR 22
TC 7
Z9 7
U1 0
U2 0
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0975-9476
EI 0976-2809
J9 J AYURVEDA INTEGR ME
JI J. Ayurveda Integr. Med.
PD APR-JUN
PY 2020
VL 11
IS 2
BP 110
EP 113
DI 10.1016/j.jaim.2020.01.002
PG 4
WC Integrative & Complementary Medicine
WE Emerging Sources Citation Index (ESCI)
SC Integrative & Complementary Medicine
GA MH7LH
UT WOS:000546905300005
PM 32247570
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Castaldo, L
   Narváez, A
   Izzo, L
   Graziani, G
   Gaspari, A
   Di Minno, G
   Ritieni, A
AF Castaldo, Luigi
   Narvaez, Alfonso
   Izzo, Luana
   Graziani, Giulia
   Gaspari, Anna
   Di Minno, Giovanni
   Ritieni, Alberto
TI Red Wine Consumption and Cardiovascular Health
SO MOLECULES
LA English
DT Review
DE red wine; resveratrol; polyphenols; alcohol; cardioprotective;
   antioxidants
ID MYOCARDIAL-INFARCTION; LIQUID-CHROMATOGRAPHY; PHENOLIC COMPOSITION;
   ALCOHOL-CONSUMPTION; ANTIOXIDANT ACTIVITY; DIETARY FLAVONOIDS; PRIMARY
   PREVENTION; METABOLIC SYNDROME; TRANS-RESVERATROL; OAK ELLAGITANNINS
AB Wine is a popular alcoholic beverage that has been consumed for hundreds of years. Benefits from moderate alcohol consumption have been widely supported by the scientific literature and, in this line, red wine intake has been related to a lesser risk for coronary heart disease (CHD). Experimental studies and meta-analyses have mainly attributed this outcome to the presence in red wine of a great variety of polyphenolic compounds such as resveratrol, catechin, epicatechin, quercetin, and anthocyanin. Resveratrol is considered the most effective wine compound with respect to the prevention of CHD because of its antioxidant properties. The mechanisms responsible for its putative cardioprotective effects would include changes in lipid profiles, reduction of insulin resistance, and decrease in oxidative stress of low-density lipoprotein cholesterol (LDL-C). The aim of this review is to summarize the accumulated evidence correlating moderate red wine consumption with prevention of CHD by focusing on the different mechanisms underlying this relationship. Furthermore, the chemistry of wine as well as chemical factors that influence the composition of the bioactive components of red wine are also discussed.
C1 [Castaldo, Luigi; Narvaez, Alfonso; Izzo, Luana; Graziani, Giulia; Gaspari, Anna; Ritieni, Alberto] Univ Naples Federico II, Fac Pharm, Dept Pharm, Via Domenico Montesano 49, I-80131 Naples, Italy.
   [Castaldo, Luigi; Di Minno, Giovanni] Univ Naples Federico II, Dept Clin Med & Surg, Via S Pansini 5, I-80131 Naples, Italy.
C3 University of Naples Federico II; University of Naples Federico II
RP Ritieni, A (corresponding author), Univ Naples Federico II, Fac Pharm, Dept Pharm, Via Domenico Montesano 49, I-80131 Naples, Italy.
EM luigi.castaldo2@unina.it; alfonsonsimon@gmail.com; luana.izzo@unina.it;
   giulia.graziani@unina.it; annagaspari@virgilio.it; diminno@unina.it;
   alberto.ritieni@unina.it
RI Graziani, Giulia/AAN-4828-2020; Ritieni, Alberto/G-8490-2012; Castaldo,
   Luigi/AFY-3423-2022
OI gaspari, anna/0000-0001-7155-8624; NARVAEZ, ALFONSO/0000-0002-4328-2330;
   Graziani, Giulia/0000-0003-3070-5389; Castaldo,
   Luigi/0000-0001-6883-9396; Ritieni, Alberto/0000-0003-0314-8839; Izzo,
   Luana/0000-0002-8365-9032
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NR 130
TC 164
Z9 173
U1 7
U2 76
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1420-3049
J9 MOLECULES
JI Molecules
PD OCT
PY 2019
VL 24
IS 19
AR 3626
DI 10.3390/molecules24193626
PG 20
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA JM5GK
UT WOS:000496242300211
PM 31597344
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Zhou, J
   Farah, BL
   Sinha, RA
   Wu, YJ
   Singh, BK
   Bay, BH
   Yang, CS
   Yen, PM
AF Zhou, Jin
   Farah, Benjamin Livingston
   Sinha, Rohit Anthony
   Wu, Yajun
   Singh, Brijesh Kumar
   Bay, Boon-Huat
   Yang, Chung S.
   Yen, Paul Michael
TI Epigallocatechin-3-Gallate (EGCG), a Green Tea Polyphenol, Stimulates
   Hepatic Autophagy and Lipid Clearance
SO PLOS ONE
LA English
DT Article
ID METABOLIC SYNDROME; POTENTIAL-ROLE; DISEASE; OBESITY; CELLS;
   (-)-EPIGALLOCATECHIN-3-GALLATE; STRESS; HEALTH; INJURY; AMPK
AB Epigallocatechin gallate (EGCG) is a major polyphenol in green tea that has been shown to have anti-inflammatory, anticancer, anti-steatotic effects on the liver. Autophagy also mediates similar effects; however, it is not currently known whether EGCG can regulate hepatic autophagy. Here, we show that EGCG increases hepatic autophagy by promoting the formation of autophagosomes, increasing lysosomal acidification, and stimulating autophagic flux in hepatic cells and in vivo. EGCG also increases phosphorylation of AMPK, one of the major regulators of autophagy. Importantly, siRNA knockdown of AMPK abrogated autophagy induced by EGCG. Interestingly, we observed lipid droplet within autophagosomes and autolysosomes and increased lipid clearance by EGCG, suggesting it promotes lipid metabolism by increasing autophagy. In mice fed with high-fat/western style diet (HFW; 60% energy as fat, reduced levels of calcium, vitamin D3, choline, folate, and fiber), EGCG treatment reduces hepatosteatosis and concomitantly increases autophagy. In summary, we have used genetic and pharmacological approaches to demonstrate EGCG induction of hepatic autophagy, and this may contribute to its beneficial effects in reducing hepatosteatosis and potentially some other pathological liver conditions.
C1 [Zhou, Jin; Farah, Benjamin Livingston; Sinha, Rohit Anthony; Singh, Brijesh Kumar; Yen, Paul Michael] Duke NUS Grad Med Hool, Program Cardiovaular & Metab Disorders, Singapore, Singapore.
   [Wu, Yajun; Bay, Boon-Huat] Natl Univ Singapore, Dept Anat, Yong Loo Lin Hool Med, Singapore 117548, Singapore.
   [Yen, Paul Michael] Duke Univ, Med Ctr, Sarah W Stedman Nutr & Metab Ctr, Dept Med & Pharmacol, Durham, NC USA.
   [Yen, Paul Michael] Duke Univ, Med Ctr, Sarah W Stedman Nutr & Metab Ctr, Dept Canc Biol, Durham, NC USA.
   [Yang, Chung S.] Rutgers State Univ, Ernest Mario Hool Pharm, Dept Biol Chem, Piataway, NJ USA.
C3 National University of Singapore; Duke University; Duke University;
   Rutgers University System; Rutgers University New Brunswick
RP Yen, PM (corresponding author), Duke NUS Grad Med Hool, Program Cardiovaular & Metab Disorders, Singapore, Singapore.
EM paul.yen@duke-nus.edu.sg
RI Sinha, Rohit/GXV-2427-2022; Yen, Paul/V-9857-2019; Singh, Brijesh
   Kumar/C-1093-2009
OI Yen, Paul Michael/0000-0002-3790-8114; Wu, Yajun/0000-0001-9598-4433;
   Singh, Brijesh Kumar/0000-0003-4615-3988
FU Duke-NUS Graduate Medical hool Faculty Funds; Ministry of Health,
   Ministry of Education, and Ministry of Trade, Singapore; A*StaR
FX This work was supported by Duke-NUS Graduate Medical hool Faculty Funds
   (PMY) sponsored by the Ministry of Health, Ministry of Education, and
   Ministry of Trade, Singapore and A*StaR. The funders had no role in
   study design, data collection and analysis, decision to publish, or
   preparation of the manuript.
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NR 27
TC 51
Z9 62
U1 2
U2 43
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JAN 29
PY 2014
VL 9
IS 1
AR e87161
DI 10.1371/journal.pone.0087161
PG 10
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 301ZC
UT WOS:000330570000111
PM 24489859
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Lu, M
   Wang, BG
   Rong, CY
   Wang, Y
   Zhang, WH
AF Lu, Ming
   Wang, Baoguo
   Rong, Chunyan
   Wang, Yin
   Zhang, Weihua
TI Therapeutic challenges and new therapeutic targets for combined
   capillary pulmonary hypertension: a review
SO FRONTIERS IN MEDICINE
LA English
DT Review
DE combined pre-and postcapillary pulmonary hypertension (Cpc-PH);
   pathophysiological mechanisms; targeted therapy; current medical and
   surgical treatments; clinical trials; pulmonary vascular resistance
   (PVR)
ID CHRONIC HEART-FAILURE; RANDOMIZED CONTROLLED-TRIAL;
   ARTERIAL-HYPERTENSION; SYSTEMIC-SCLEROSIS; EJECTION FRACTION;
   DOUBLE-BLIND; RIOCIGUAT; RECEPTOR; SURVIVAL; DENERVATION
AB With a high frequency and a poor prognosis, combined pre-and post-capillary pulmonary hypertension (Cpc-PH) is a significant subtype of pulmonary hypertension linked to left-sided heart disease (PH-LHD). The complicated pathophysiology of Cpc-PH is primarily characterized by elevated pulmonary venous pressure leading to an increase in retrocapillary pressure, which is followed by elevated pulmonary artery pressure and a marked rise in pulmonary vascular resistance (PVR). There is currently no well-defined treatment plan for Cpc-PH, and there are numerous obstacles to overcome. In patients with Cpc-PH, the effectiveness of targeted medications for pulmonary hypertension is limited and debatable. Recent research has revealed that the prevalence and progression of Cpc-PH may be influenced by genetic factors, metabolic syndrome, oxidative stress, and fibrosis. To help doctors better manage and treat patients with Cpc-PH, this review provides a detailed description of the disease's epidemiology, pathogenesis, diagnostic techniques, current treatment status, and potential therapeutic targets.
C1 [Lu, Ming; Wang, Baoguo; Rong, Chunyan; Wang, Yin; Zhang, Weihua] Jilin Univ, Changchun, Peoples R China.
C3 Jilin University
RP Zhang, WH (corresponding author), Jilin Univ, Changchun, Peoples R China.
EM weihua@jlu.edu.cn
RI zhang, weihua/JMC-4368-2023
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NR 155
TC 0
Z9 0
U1 0
U2 0
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 2296-858X
J9 FRONT MED-LAUSANNE
JI Front. Med.
PD MAY 2
PY 2025
VL 12
AR 1579112
DI 10.3389/fmed.2025.1579112
PG 18
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 2ZM6A
UT WOS:001495019900001
PM 40385572
DA 2025-06-11
ER

PT J
AU Xu, M
   Lv, DQ
   Wei, HX
   Li, Z
   Jin, SQ
   Liu, QH
   Zhang, Y
   Liu, YF
AF Xu, Ming
   Lv, Dongqing
   Wei, Hongxia
   Li, Zhe
   Jin, Shuqing
   Liu, Qinhao
   Zhang, Yi
   Liu, Yunfeng
TI Effects of antidiabetic agents on lipid metabolism of skeletal muscle: A
   narrative review
SO DIABETES OBESITY & METABOLISM
LA English
DT Review
DE antidiabetic drug; body composition; drug mechanism; incretin therapy;
   type 2 diabetes; weight control
ID ACTIVATED PROTEIN-KINASE; TYPE-2 DIABETES-MELLITUS; HIGH-FAT DIET;
   IMPROVES INSULIN SENSITIVITY; PEPTIDE-1 RECEPTOR AGONISTS;
   MITOCHONDRIAL-FUNCTION; ACID OXIDATION; ADIPOSE-TISSUE; RESVERATROL
   SUPPLEMENTATION; INDUCED INFLAMMATION
AB Metabolic syndrome-related diseases frequently involve disturbances in skeletal muscle lipid metabolism. The accumulation of lipid metabolites, lipid-induced mitochondrial stress in skeletal muscle cells, as well as the inflammation of adjacent adipose tissue, are associated with the development of insulin resistance and metabolic dysfunction. Consequently, when antidiabetic medications are used to treat various chronic conditions related to hyperglycaemia, the impact on skeletal muscle lipid metabolism should not be overlooked. However, current research has predominantly focused on muscle mass rather than skeletal muscle lipid metabolism and its interplay with glucose metabolism. In this review, we summarised the latest research on the effects of antidiabetic drugs and certain natural compounds with antidiabetic activity on skeletal muscle lipid metabolism, focusing on data from preclinical to clinical studies. Given the widespread use of antidiabetic drugs, a better understanding of their effects on skeletal muscle lipid metabolism merits further attention in future research.
C1 [Xu, Ming; Lv, Dongqing; Wei, Hongxia; Li, Zhe; Jin, Shuqing; Liu, Qinhao; Liu, Yunfeng] Shanxi Med Univ, Hosp 1, Dept Endocrinol, Taiyuan, Peoples R China.
   [Xu, Ming; Lv, Dongqing; Wei, Hongxia; Li, Zhe; Jin, Shuqing; Liu, Qinhao; Liu, Yunfeng] Shanxi Med Univ, Clin Med Coll 1, Taiyuan, Peoples R China.
   [Zhang, Yi] Shanxi Med Univ, Dept Pharmacol, Taiyuan, Peoples R China.
   [Zhang, Yi] Shanxi Med Univ, Med Basic Res Innovat Ctr Chron Kidney Dis, Minist Educ, Taiyuan, Peoples R China.
C3 Shanxi Medical University; Shanxi Medical University; Shanxi Medical
   University; Ministry of Education - China; Shanxi Medical University
RP Liu, YF (corresponding author), Shanxi Med Univ, Hosp 1, Dept Endocrinol, Taiyuan, Peoples R China.; Zhang, Y (corresponding author), Shanxi Med Univ, Dept Pharmacol, Taiyuan, Peoples R China.
EM yizhang@sxmu.edu.cn; nectarliu@163.com
RI Yunfeng, Liu/JDC-5735-2023
OI Li, Zhe/0009-0004-9900-506X
FU National Natural Science Foundation of China;  [82073909]
FX The co-authors thank the National Natural Science Foundation of China
   (82073909) for their support.
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NR 160
TC 0
Z9 0
U1 6
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1462-8902
EI 1463-1326
J9 DIABETES OBES METAB
JI Diabetes Obes. Metab.
PD APR
PY 2025
VL 27
IS 4
BP 1693
EP 1707
DI 10.1111/dom.16189
EA JAN 2025
PG 15
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA Z6W3X
UT WOS:001395526100001
PM 39807619
DA 2025-06-11
ER

PT J
AU Igbayilola, YD
   Gujja, MG
AF Igbayilola, Y. D.
   Gujja, M. G.
TI Alpha-amylase and alpha-glucosidase upregulated glucose homeostasis in
   high-fat fed wistar rats supplemented with cocoa flavonoid-rich aqueous
SO FOOD BIOSCIENCE
LA English
DT Article
DE Amylase; Cocoa; Flavonoid; Glucose; Wistar rats
ID METABOLIC SYNDROME; OXIDATIVE STRESS; TOXICITY; EXTRACTS
AB This study investigates the impact of cocoa (Theobroma Cacao L.) flavonoid-rich aqueous supplementation on alpha-amylase and alpha-glucosidase enzymes, influencing glucose homeostasis in Wistar rats. Over 12 weeks, Wistar rats underwent a high-fat diet induction for obesity. Group assignments included a negative control on a normal diet, a positive control on a normal diet with 600 mg/kg cocoa-containing flavonoid-rich water extract, a fat-treated group on a high-fat diet with the same cocoa extract, and an untreated fat group exclusively on a highfat diet. The cocoa extract was orally administered for 14 days, evaluating various metabolic parameters. Results showed that the rats displayed improved glucose tolerance, reduced fasting serum glucose, and enhanced insulin sensitivity with increased alpha-amylase and alpha-glucosidase levels compared to the untreated high-fat group and controls. This study suggests that cocoa-derived polyphenols hold potential in mitigating high-fat dietinduced adverse effects on glucose metabolism by regulating the secretion of alpha-amylase and alphaglucosidase in rats.
C1 [Igbayilola, Y. D.; Gujja, M. G.] Baze Univ, Dept Human Physiol, Plot 686 Cadastral Zone C00, Jabi, Abuja, Nigeria.
RP Igbayilola, YD (corresponding author), Baze Univ, Dept Human Physiol, Plot 686 Cadastral Zone C00, Jabi, Abuja, Nigeria.
EM yusuff.igbayilola@bazeuniversity.edu.ng; gremamariamgujja@gmail.com
RI Igbayilola, Yusuff/GNP-4641-2022
OI Dimeji, Igbayilola/0000-0002-2405-5554
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NR 48
TC 1
Z9 1
U1 1
U2 5
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2212-4292
EI 2212-4306
J9 FOOD BIOSCI
JI Food Biosci.
PD JUN
PY 2024
VL 59
AR 104070
DI 10.1016/j.fbio.2024.104070
EA APR 2024
PG 10
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA SU9W1
UT WOS:001237087800001
DA 2025-06-11
ER

PT J
AU Ugovsek, S
   Zupan, J
   Likozar, AR
   Sebestjen, M
AF Ugovsek, Sabina
   Zupan, Janja
   Likozar, Andreja Rehberger
   Sebestjen, Miran
TI Influence of lipid-lowering drugs on inflammation: what is yet to be
   done?
SO ARCHIVES OF MEDICAL SCIENCE
LA English
DT Article
DE atherosclerosis; inflammation; C-reactive protein; lipid-lowering drugs
ID C-REACTIVE PROTEIN; EXTENDED-RELEASE NIACIN; DENSITY-LIPOPROTEIN
   CHOLESTEROL; HIGH CARDIOVASCULAR RISK; CORONARY-ARTERY-DISEASE; STATIN
   THERAPY; METABOLIC SYNDROME; OXIDATIVE STRESS; ANTISENSE
   OLIGONUCLEOTIDES; LDL CHOLESTEROL
AB Atherosclerosis is a chronic inflammatory disease that is associated with risk of cardiovascular events. The best-characterised and well-standardised clin-ical indicator of inflammation is C-reactive protein. Current evidence-based drug therapies for prevention and treatment of cardiovascular diseases are mainly focused on reduction of low-density lipoprotein cholesterol. However, these drugs do not provide sufficient protection against recurrent cardio-vascular events. One of the possible mechanisms behind this recurrence might be the persistence of residual inflammation. For the most common -ly used lipid-lowering drugs, the statins, their reduction of cardiovascular events goes beyond lowering of low-density lipoprotein cholesterol. Here, we review the effects of these lipid-lowering drugs on inflammation, con -sidering statins, ezetimibe, fibrates, niacin, proprotein convertase subtilisin/ kexin type 9 inhibitors, bempedoic acid, ethyl eicosapentaenoic acid and antisense oligonucleotides. We focus in particular on C-reactive protein, and discuss how the effects of the statins might be related to reduced rates of cardiovascular events.
C1 [Ugovsek, Sabina; Sebestjen, Miran] Univ Ljubljana, Fac Med, Dept Internal Med, Ljubljana, Slovenia.
   [Zupan, Janja] Univ Ljubljana, Fac Pharm, Dept Clin Biochem, Ljubljana, Slovenia.
   [Likozar, Andreja Rehberger; Sebestjen, Miran] Univ Med Ctr, Dept Vasc Dis, Ljubljana, Slovenia.
   [Sebestjen, Miran] Univ Med Ctr Ljubljana, Dept Cardiol, Ljubljana, Slovenia.
C3 University of Ljubljana; University of Ljubljana; University Medical
   Centre Ljubljana; University Medical Centre Ljubljana
RP Sebestjen, M (corresponding author), Univ Ljubljana, Univ Med Ctr Ljubljana, Fac Med, Dept Cardiol,Dept Vasc Dis, Ljubljana, Slovenia.
EM miran.sebestjen@guest.arnes.si
RI Zupan, Janja/L-6760-2017; Sebestjen, Miran/ABA-9864-2021
OI Ugovsek, Sabina/0000-0002-2056-4781; Sebestjen,
   Miran/0000-0001-9907-3522; Rehberger Likozar,
   Andreja/0000-0002-8592-192X
CR Aday AW, 2018, CIRCULATION, V138, P2330, DOI [10.1161/CIRCULATIONAHA.118.035432, 10.1161/CIRCULATIONAHA.118.034645]
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NR 90
TC 10
Z9 10
U1 0
U2 3
PU TERMEDIA PUBLISHING HOUSE LTD
PI POZNAN
PA KLEEBERGA 2, POZNAN, 61-615, POLAND
SN 1734-1922
EI 1896-9151
J9 ARCH MED SCI
JI Arch. Med. Sci.
PD JUL
PY 2022
VL 18
IS 4
BP 855
EP 869
DI 10.5114/aoms/133936
PG 15
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 2R4IU
UT WOS:000821077400002
PM 35832698
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Zhang, S
   Peng, XQ
   Yang, S
   Li, XY
   Huang, MY
   Wei, SB
   Liu, JX
   He, GP
   Zheng, HY
   Yang, L
   Li, HY
   Fan, Q
AF Zhang, Sheng
   Peng, Xueqiang
   Yang, Shuo
   Li, Xinyu
   Huang, Mingyao
   Wei, Shibo
   Liu, Jiaxing
   He, Guangpeng
   Zheng, Hongyu
   Yang, Liang
   Li, Hangyu
   Fan, Qing
TI The regulation, function, and role of lipophagy, a form of selective
   autophagy, in metabolic disorders
SO CELL DEATH & DISEASE
LA English
DT Review
ID CHAPERONE-MEDIATED AUTOPHAGY; DEPENDENT LIPID-METABOLISM; FATTY-ACID; ER
   STRESS; CELL-DEATH; ENDOPLASMIC-RETICULUM; DROPLET BIOGENESIS; CARGO
   RECOGNITION; MECHANISM; PROTECTS
AB Autophagy is a conserved method of quality control in which cytoplasmic contents are degraded via lysosomes. Lipophagy, a form of selective autophagy and a novel type of lipid metabolism, has recently received much attention. Lipophagy is defined as the autophagic degradation of intracellular lipid droplets (LDs). Although much remains unknown, lipophagy appears to play a significant role in many organisms, cell types, metabolic states, and diseases. It participates in the regulation of intracellular lipid storage, intracellular free lipid levels (e.g., fatty acids), and energy balance. However, it remains unclear how intracellular lipids regulate autophagy. Impaired lipophagy can cause cells to become sensitive to death stimuli and may be responsible for the onset of a variety of diseases, including nonalcoholic fatty liver disease and metabolic syndrome. Like autophagy, the role of lipophagy in cancer is poorly understood, although analysis of specific autophagy receptors has helped to expand the diversity of chemotherapeutic targets. These studies have stimulated increasing interest in the role of lipophagy in the pathogenesis and treatment of cancer and other human diseases.
C1 [Zhang, Sheng; Peng, Xueqiang; Yang, Shuo; Li, Xinyu; Huang, Mingyao; Wei, Shibo; Liu, Jiaxing; He, Guangpeng; Zheng, Hongyu; Yang, Liang; Li, Hangyu; Fan, Qing] China Med Univ, Affiliated Hosp 4, Dept Gen Surg, Shenyang 110032, Peoples R China.
C3 China Medical University
RP Fan, Q (corresponding author), China Med Univ, Affiliated Hosp 4, Dept Gen Surg, Shenyang 110032, Peoples R China.
EM qingfan@cmu.edu.cn
RI He, Guangpeng/HLG-4065-2023; li, hangyu/LIG-6449-2024; Zheng,
   Hongyu/AAP-2039-2021
OI He, Guangpeng/0000-0002-7528-7638; Huang, Mingyao/0009-0004-4566-4350
FU National Natural Science Foundation of China [82003040]; Natural Science
   Foundation of Liaoning Province [2020-BS-103]
FX This study was supported by grants from National Natural Science
   Foundation of China (No. 82003040), Natural Science Foundation of
   Liaoning Province (2020-BS-103).
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NR 147
TC 137
Z9 148
U1 12
U2 90
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 2041-4889
J9 CELL DEATH DIS
JI Cell Death Dis.
PD FEB 8
PY 2022
VL 13
IS 2
AR 132
DI 10.1038/s41419-022-04593-3
PG 11
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA YZ1BA
UT WOS:000755216400014
PM 35136038
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Yun, JM
   Lee, M
   Kim, D
   Prasad, KS
   Eun, S
   Kim, OK
   Lee, J
AF Yun, Jeong Moon
   Lee, Minhee
   Kim, Dakyung
   Prasad, K. Shyam
   Eun, Sangwon
   Kim, Ok-Kyung
   Lee, Jeongmin
TI Standardized Saw Palmetto Extract Directly and Indirectly Affects
   Testosterone Biosynthesis and Spermatogenesis
SO JOURNAL OF MEDICINAL FOOD
LA English
DT Article
DE aging; andropause; saw palmetto extract; spermatogenesis; testosterone
ID LUTEINIZING-HORMONE; MALE MENOPAUSE; CELLS; TESTES
AB We investigated whether a standardized saw palmetto extract (SP, mixture of supercritical extract and ethanol extract at a ratio of 9.5 to 0.5) can relieve the symptoms of andropause, including metabolic syndrome, and decreases in muscle endurance and spermatogenesis, in old rats. Twenty-four-week-old male Sprague Dawley rats received oral supplementation of SP at 40, 80, and 160 mg/kg body weight (bw) for 4 weeks. We found that SP supplementation reduced body weight gain by decreasing visceral and epididymal fat weights and the levels of serum triglycerides, total cholesterol, and low-density lipoprotein/very low-density lipoprotein cholesterol. In addition, SP supplementation increased muscle endurance, sperm counts, and testosterone biosynthesis through hormonal regulation. In Leydig cells under hydrogen peroxide-induced oxidative stress, SP treatment directly induced testosterone biosynthesis by activating the mRNA expression of the genes encoding 17,20-desmolase and 3 beta-hydroxysteroid dehydrogenase 4. In conclusion, our results suggest that supplementation of SP may be useful for alleviating the symptoms of andropause via direct and indirect regulation of testosterone biosynthesis.
C1 [Yun, Jeong Moon; Kim, Dakyung] PENS Co Ltd, Seoul, South Korea.
   [Lee, Minhee; Lee, Jeongmin] Kyung Hee Univ, Dept Med Nutr, Yongin 17104, South Korea.
   [Lee, Minhee; Lee, Jeongmin] Kyung Hee Univ, Res Inst Clin Nutr, Seoul, South Korea.
   [Prasad, K. Shyam] Vidya Herbs Pvt Ltd, R&D Ctr Excellence, Bangalore, Karnataka, India.
   [Eun, Sangwon] Daehan Chemtech Co Ltd, R&D Div, Seoul, South Korea.
   [Kim, Ok-Kyung] Chonnam Natl Univ, Div Food & Nutr & Human Ecol, Res Inst, Gwangju 61186, South Korea.
C3 Kyung Hee University; Kyung Hee University; Chonnam National University
RP Lee, J (corresponding author), Kyung Hee Univ, Dept Med Nutr, Yongin 17104, South Korea.; Kim, OK (corresponding author), Chonnam Natl Univ, Div Food & Nutr & Human Ecol, Res Inst, Gwangju 61186, South Korea.
EM 20woskxm@jnu.ac.kr; jlee2007@khu.ac.kr
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NR 21
TC 2
Z9 3
U1 1
U2 7
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1096-620X
EI 1557-7600
J9 J MED FOOD
JI J. Med. Food
PD JUN 1
PY 2021
VL 24
IS 6
BP 617
EP 625
DI 10.1089/jmf.2021.K.0021
PG 9
WC Chemistry, Medicinal; Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Food Science & Technology; Nutrition &
   Dietetics
GA SW7PI
UT WOS:000664704500007
PM 34161166
DA 2025-06-11
ER

PT J
AU Usal, M
   Veyrenc, S
   Darracq--Ghitalla-Ciock, M
   Regnault, C
   Sroda, S
   Fini, JB
   Canlet, C
   Tremblay-Franco, M
   Raveton, M
   Reynaud, S
AF Usal, Marie
   Veyrenc, Sylvie
   Darracq--Ghitalla-Ciock, Marie
   Regnault, Christophe
   Sroda, Sophie
   Fini, Jean-Baptiste
   Canlet, Cecile
   Tremblay-Franco, Marie
   Raveton, Muriel
   Reynaud, Stephane
TI Transgenerational metabolic disorders and reproduction defects induced
   by benzo[a]pyrene in Xenopus tropicalis
SO ENVIRONMENTAL POLLUTION
LA English
DT Article
DE Endocrine disruptor; Transgenerational; Metabolic syndrome; Amphibian
   population decline; Xenopus tropicalis
ID ENDOPLASMIC-RETICULUM STRESS; ENDOCRINE DISRUPTORS; AMPHIBIAN DECLINES;
   EXPOSURE; INSULIN; ATRAZINE; FROGS; ACID; GLUCONEOGENESIS; METAMORPHOSIS
AB Metabolic disorders induced by endocrine disruptors (ED) may contribute to amphibian population declines but no transgenerational studies have evaluated this hypothesis. Here we show that Xenopus tropicalis, exposed from the tadpole stage, to the ED benzo[a]pyrene (BaP, 50 ng.L-1) produced F2 progeny with delayed metamorphosis and sexual maturity. At the adult stage, F2-BaP females displayed fatty liver with inflammation, tissue disorganization and metabolomic and transcriptomic signatures typical of nonalcoholic steato-hepatitis (NASH). This phenotype, similar to that observed in F0 and F1 females, was accompanied by a pancreatic insulin secretory defect. Metabolic disrupted F2-BaP females laid eggs with metabolite contents significantly different from the control and these eggs did not produce viable progeny. This study demonstrated that an ED can induce transgenerational disruption of metabolism and population collapse in amphibians under laboratory conditions. These results show that ED benzo[a]pyrene can impact metabolism over multiple generations and support epidemiological studies implicating environmental EDs in metabolic diseases in humans. (C) 2020 Elsevier Ltd. All rights reserved.
C1 [Usal, Marie; Veyrenc, Sylvie; Darracq--Ghitalla-Ciock, Marie; Regnault, Christophe; Sroda, Sophie; Raveton, Muriel; Reynaud, Stephane] Univ Grenoble Alpes, Univ Savoie Mt Blanc, LECA, CNRS, F-38000 Grenoble, France.
   [Fini, Jean-Baptiste] Museum Natl Hist Nat, Unite PhyMA Lab, Adaptat Vivant, 7 Rue Cuvier, F-75005 Paris, France.
   [Canlet, Cecile; Tremblay-Franco, Marie] Paul Sabatier Univ, Toulouse Univ, Toxalim Res Ctr Food Toxicol, INRAE UMR 1331,ENVT,INP Purpan, F-31027 Toulouse, France.
   [Canlet, Cecile; Tremblay-Franco, Marie] MetaboHUB, Natl Infrastruct Metabol & Fluxom, Metatoul Axiom Platform, Toxalim,INRAE UMR 1331, F-31027 Toulouse, France.
C3 Communaute Universite Grenoble Alpes; Universite Grenoble Alpes (UGA);
   Centre National de la Recherche Scientifique (CNRS); Universite Savoie
   Mont Blanc; Museum National d'Histoire Naturelle (MNHN); Universite de
   Toulouse; Universite Toulouse III - Paul Sabatier; Universite Federale
   Toulouse Midi-Pyrenees (ComUE); Ecole Nationale Veterinaire de Toulouse;
   INRAE; INRAE; Universite Federale Toulouse Midi-Pyrenees (ComUE);
   Universite de Toulouse; Institut National Polytechnique de Toulouse;
   Universite Toulouse III - Paul Sabatier
RP Reynaud, S (corresponding author), Univ Grenoble Alpes, Univ Savoie Mt Blanc, LECA, CNRS, F-38000 Grenoble, France.
EM marie.usal@hotmail.fr; sylvie.veyrenc@univ-grenoble-alpes.fr;
   marieghitalla@gmail.com; christophe.regnault@gmail.com;
   sophie.sroda@univ-grenoble-alpes.fr; fini@mnhn.fr;
   cecile.canlet@inrae.fr; marie.tremblay-franco@inrae.fr;
   muriel.raveton@univ-grenoble-alpes.fr;
   stephane.reynaud@univ-grenoble-alpes.fr
RI Sroda, Sophie/IQV-5068-2023; Raveton, Muriel/K-1403-2013; Reynaud,
   Stephane/H-5493-2013
OI Reynaud, Stephane/0000-0003-0248-0602; Darracq--Ghitalla-Ciock,
   Marie/0000-0002-8411-2362; FINI, Jean-Baptiste/0000-0002-5620-2600
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NR 79
TC 16
Z9 17
U1 5
U2 43
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0269-7491
EI 1873-6424
J9 ENVIRON POLLUT
JI Environ. Pollut.
PD JAN 15
PY 2021
VL 269
AR 116109
DI 10.1016/j.envpol.2020.116109
PG 12
WC Environmental Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology
GA PN4CS
UT WOS:000604429000038
PM 33234375
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Cruz, KJC
   de Oliveira, ARS
   de Freitas, ST
   Henriques, GS
   Marreiro, DD
AF Cruz, Kyria J. C.
   de Oliveira, Ana R. S.
   de Freitas, Suelem T.
   Henriques, Gilberto S.
   Marreiro, Dilina do Nascimento
TI Hypomagnesemia in Obese Subjects: Evidence of Systematic Review and
   Meta-analysis
SO CURRENT NUTRITION & FOOD SCIENCE
LA English
DT Review
DE Human; hypomagnesemia; magnesium; obesity; observational study; review
ID SERUM MAGNESIUM LEVELS; C-REACTIVE PROTEIN; METABOLIC SYNDROME;
   GLUCOSE-TOLERANCE; OXIDATIVE STRESS; NATIONAL-HEALTH; DEFICIENCY;
   COPPER; IRON; ZINC
AB Background: Magnesium deficiency is a global nutritional problem which seems to influence obesity-associated metabolic disorders because magnesium plays an important role in the prevention and treatment of many diseases.
   Objective: We conducted a systematic review and meta-analysis to evaluate the relationship between plasma magnesium concentrations and obesity.
   Methods: A systematic review and meta-analysis of case-control studies was conducted. Relevant studies were identified from a literature search using electronic databases.
   Results: Ten case-control studies were evaluated in this meta-analysis. Results demonstrated that obese individuals presented lower plasma magnesium concentration than healthy individuals (standardized mean difference [SMD] = -0.44, 95% confidence interval = -0.88 to -0.01). In subgroup analyses, there were differences in plasma magnesium concentration between obese and healthy individuals according to study location, gender, case age, control age, method for assessment of magnesium concentration and study quality. Furthermore, meta-regression analyses showed that the source of heterogeneity of magnesium levels among studies was control age.
   Conclusion: Evidence of this systematic review and meta-analysis show hypomagnesemia in obese individuals of both genders.
C1 [Cruz, Kyria J. C.; de Oliveira, Ana R. S.; Marreiro, Dilina do Nascimento] Univ Fed Piaui, Dept Nutr, Campus Minister Petronio Portela, Teresina, Piaui, Brazil.
   [de Freitas, Suelem T.] Fed Univ, Dean Planning & Inst Dev, Belem, Para, Brazil.
   [Henriques, Gilberto S.] Univ Fed Minas Gerais, Dept Nutr, Belo Horizonte, MG, Brazil.
C3 Universidade Federal do Piaui; Universidade Federal de Minas Gerais
RP Marreiro, DD (corresponding author), Univ Fed Piaui, Dept Nutr, Campus Minister Petronio Portela, Teresina, Piaui, Brazil.
EM dilina.marreiro@gmail.com
RI CRUZ, KYRIA/LOQ-9371-2024; Henriques, Gilberto/LGZ-7328-2024
OI do Nascimento Marreiro, Dilina/0000-0002-7550-1403; Henriques,
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NR 42
TC 2
Z9 2
U1 2
U2 7
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1573-4013
EI 2212-3881
J9 CURR NUTR FOOD SCI
JI Curr. Nutr. Food Sci.
PY 2020
VL 16
IS 7
BP 1044
EP 1051
DI 10.2174/1573401315666190821110459
PG 8
WC Nutrition & Dietetics
WE Emerging Sources Citation Index (ESCI)
SC Nutrition & Dietetics
GA NM8EB
UT WOS:000568324900005
DA 2025-06-11
ER

PT J
AU Samji, NS
   Heda, R
   Satapathy, SK
AF Samji, Naga Swetha
   Heda, Rajiv
   Satapathy, Sanjaya K.
TI Peri-transplant management of nonalcoholic fatty liver disease in liver
   transplant candidates
SO TRANSLATIONAL GASTROENTEROLOGY AND HEPATOLOGY
LA English
DT Review
DE Liver transplant; peri-transplant management; non-alcoholic fatty liver
   disease (NAFLD); non-alcoholic steatohepatitis (NASH); cirrhosis
ID PORTAL-VEIN THROMBOSIS; CHRONIC KIDNEY-DISEASE; CORONARY-ARTERY-DISEASE;
   BODY-MASS INDEX; DOBUTAMINE STRESS ECHOCARDIOGRAPHY; RAPIDLY GROWING
   INDICATION; SEVERELY OBESE-PATIENTS; LONG-TERM SURVIVAL; INCREASED RISK;
   CRYPTOGENIC CIRRHOSIS
AB The incidence of non-alcoholic fatty liver disease (NAFLD) is rapidly growing, affecting 25% of the world population. Non-alcoholic steatohepatitis (NASH) is the most severe form of NAFLD and affects 1.5% to 6.5% of the world population. Its rising incidence will make end-stage liver disease (ESLD) due to NASH the number one indication for liver transplantation (LT) in the next 10 to 20 years, overtaking Hepatitis C. Patients with NASH also have a high prevalence of associated comorbidities such as type 2 diabetes, obesity, metabolic syndrome, cardiovascular disease, and chronic kidney disease (CKD), which must be adequately managed during the peritransplant period for optimal post-transplant outcomes. The focus of this review article is to provide a comprehensive overview of the unique challenges these patients present in the peritransplant period, which comprises the pre-transplant, intraoperative, and immediate postoperative periods.
C1 [Samji, Naga Swetha] Tennova Cleveland Hosp, 2305 Chambliss Ave NW, Cleveland, TN USA.
   [Heda, Rajiv] Univ Tennessee, Ctr Hlth Sci, Coll Med, Memphis, TN 38163 USA.
   [Satapathy, Sanjaya K.] Northwell Hlth, Div Hepatol, Manhasset, NY USA.
   [Satapathy, Sanjaya K.] Northwell Hlth, Sandra Atlas Bass Ctr Liver Dis, Manhasset, NY USA.
C3 University of Tennessee System; University of Tennessee Health Science
   Center; Northwell Health; Northwell Health
RP Satapathy, SK (corresponding author), Sandra Atlas Bass Ctr Liver Dis & Transplantat, Div Hepatol, Liver Transplantat, 400 Community Dr, Manhasset, NY 11030 USA.; Satapathy, SK (corresponding author), Northwell Hlth, Donald & Barbara Zucker Sch Med, Med, 400 Community Dr, Manhasset, NY 11030 USA.
EM ssatapat@northwell.edu
RI Satapathy, Sanjaya/AAG-9830-2019
OI Satapathy, Sanjaya/0000-0003-0153-2829
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NR 182
TC 14
Z9 15
U1 0
U2 1
PU AME PUBLISHING COMPANY
PI SHATIN
PA FLAT-RM C 16F, KINGS WING PLAZA 1, NO 3 KWAN ST, SHATIN, HONG KONG
   00000, PEOPLES R CHINA
EI 2415-1289
J9 TRANSL GASTROENT HEP
JI Transl. Gastroenterol. Hepatol.
PD JAN
PY 2020
VL 5
AR 10
DI 10.21037/tgh.2019.09.09
PG 20
WC Gastroenterology & Hepatology
WE Emerging Sources Citation Index (ESCI)
SC Gastroenterology & Hepatology
GA JY8SD
UT WOS:000504677300010
PM 32190778
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Shimizu, S
   Tsounapi, P
   Shimizu, T
   Honda, M
   Inoue, K
   Dimitriadis, F
   Saito, M
AF Shimizu, Shogo
   Tsounapi, Panagiota
   Shimizu, Takahiro
   Honda, Masashi
   Inoue, Keiji
   Dimitriadis, Fotios
   Saito, Motoaki
TI Lower urinary tract symptoms, benign prostatic hyperplasia/benign
   prostatic enlargement and erectile dysfunction: Are these conditions
   related to vascular dysfunction?
SO INTERNATIONAL JOURNAL OF UROLOGY
LA English
DT Review
DE benign prostatic enlargement; benign prostatic hyperplasia; erectile
   dysfunction; lower urinary tract symptoms; pelvic blood flow; urinary
   bladder
ID BLADDER BLOOD-FLOW; SPONTANEOUSLY HYPERTENSIVE-RAT;
   CORONARY-ARTERY-DISEASE; POPULATION-BASED SURVEY; DETRUSOR OVERACTIVITY;
   OXIDATIVE STRESS; CHRONIC ISCHEMIA; DOPPLER ULTRASONOGRAPHY; METABOLIC
   SYNDROME; VOIDING SYMPTOMS
AB Although the pathogenesis of lower urinary tract symptoms, benign prostatic hyperplasia/benign prostatic enlargement and erectile dysfunction is poorly understood and thought to be multifactorial, it has been traditionally recognized that these conditions increase with age. There is increasing evidence that there is an association between cardiovascular disease and lower urinary tract symptoms as well as benign prostatic hyperplasia/benign prostatic enlargement and erectile dysfunction in elderly patients. Age might activate systemic vascular risk factors, resulting in disturbed blood flow. Hypertension, diabetes, hyperlipidemia and atherosclerosis are also linked to the etiology of lower urinary tract symptoms, benign prostatic hyperplasia/benign prostatic enlargement and erectile dysfunction. In the present review, we discuss the relationship between decreased pelvic blood flow and lower urinary tract symptoms, benign prostatic hyperplasia/benign prostatic enlargement and erectile dysfunction. Furthermore, we suggest possible common mechanisms underlining these urological conditions.
C1 [Shimizu, Shogo; Shimizu, Takahiro; Saito, Motoaki] Kochi Univ, Kochi Med Sch, Dept Pharmacol, Nankoku, Kochi 7838505, Japan.
   [Tsounapi, Panagiota; Honda, Masashi] Tottori Univ, Sch Med, Div Urol, Yonago, Tottori 683, Japan.
   [Inoue, Keiji] Kochi Univ, Kochi Med Sch, Dept Urol, Nankoku, Kochi 7838505, Japan.
   [Dimitriadis, Fotios] Aristotle Univ Thessaloniki, Papageorgiou Gen Hosp, Sch Med, Urol Dept B, GR-54006 Thessaloniki, Greece.
C3 Kochi University; Tottori University; Kochi University; Aristotle
   University of Thessaloniki; Papageorgiou Hospital
RP Saito, M (corresponding author), Kochi Univ, Kochi Med Sch, Dept Pharmacol, Nankoku, Kochi 7838505, Japan.
EM saitomo@kochi-u.ac.jp
RI Shimizu, Shogo/LWK-4571-2024; Dimitriadis, Fotios/D-2571-2009
OI Shimizu, Shogo/0000-0001-9564-1916
FU Japan Society for the Promotion of Science [24592431, 20591880];
   Grants-in-Aid for Scientific Research [24592431] Funding Source: KAKEN
FX This study was supported by a grant in aid from the Japan Society for
   the Promotion of Science (#24592431 and 20591880).
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NR 86
TC 27
Z9 34
U1 0
U2 14
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0919-8172
EI 1442-2042
J9 INT J UROL
JI Int. J. Urol.
PD SEP
PY 2014
VL 21
IS 9
BP 856
EP 864
DI 10.1111/iju.12501
PG 9
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA AO7AN
UT WOS:000341504400003
PM 24930630
OA Bronze
DA 2025-06-11
ER

PT J
AU Baird, TA
   Parsons, MW
   Barber, PA
   Butcher, KS
   Desmond, PM
   Tress, BM
   Colman, PG
   Jerums, G
   Chambers, BR
   Davis, SM
AF Baird, TA
   Parsons, MW
   Barber, PA
   Butcher, KS
   Desmond, PM
   Tress, BM
   Colman, PG
   Jerums, G
   Chambers, BR
   Davis, SM
TI The influence of diabetes mellitus and hyperglycaemia on stroke
   incidence and outcome
SO JOURNAL OF CLINICAL NEUROSCIENCE
LA English
DT Review
DE review; diabetes mellitus; hyperglycaemia; cerebrovascular disease
ID ACUTE MYOCARDIAL-INFARCTION; MIDDLE CEREBRAL-ARTERY; ISCHEMIC
   BRAIN-DAMAGE; RISK-FACTORS; BLOOD-GLUCOSE; CEREBROVASCULAR-DISEASE;
   CARDIOVASCULAR-DISEASE; CAROTID-ENDARTERECTOMY; MODERATE HYPERGLYCEMIA;
   STRESS HYPERGLYCEMIA
AB Diabetes mellitus is a complex metabolic syndrome with significant effects on the systemic and cerebral vasculature. The incidence and severity of ischaemic stroke are increased by the presence of diabetes, and outcome from stroke is poorer. More than one third of patients admitted with acute stroke are hyperglycaemic at presentation. Reasons for the altered prognosis in diabetes associated stroke are multifactorial. A direct influence of hyperglycaemia at the time of ischaemia is likely to be important. The use of novel methods to delineate stroke topography and pathophysiology such as MR spectroscopy, diffusion and perfusion weighted MRI appear helpful in delineating the effects of hyperglycaemia on stroke pathophysiology. Randomised clinical trials to determine optimal management for patients with hyperglycaemia following stroke are ongoing. Such trials will determine if aggressive control of acute hyperglycaemia following stroke has similar benefits to that observed following acute myocardial infarction. Clinicians responsible for stroke patients should be aware of the importance of adequate glycaemic control in both primary and secondary prevention of stroke. (C) 2002 Published by Elsevier Science Ltd.
C1 Royal Melbourne Hosp, Dept Neurol, Melbourne, Vic 3050, Australia.
   Royal Melbourne Hosp, Dept Radiol, Melbourne, Vic 3050, Australia.
   Royal Melbourne Hosp, Dept Endocrinol & Diabet, Melbourne, Vic 3050, Australia.
   Austin & Repatriat Med Ctr, Dept Neurol, Melbourne, Vic, Australia.
   Austin & Repatriat Med Ctr, Dept Endocrinol & Diabet, Melbourne, Vic, Australia.
C3 Melbourne Health; Royal Melbourne Hospital; Melbourne Health; Royal
   Melbourne Hospital; Melbourne Health; Royal Melbourne Hospital; Florey
   Institute of Neuroscience & Mental Health; Howard Florey Institute
   Affiliates; Austin Research Institute; Austin Research Institute; Florey
   Institute of Neuroscience & Mental Health; Howard Florey Institute
   Affiliates
RP Royal Melbourne Hosp, Dept Neurol, Parkville, Vic 3050, Australia.
EM sdavis@mh.org.au
RI Davis, Stephen/L-5260-2013; Parsons, Mark/G-3750-2014; Desmond,
   Patricia/D-1966-2014; Barber, P Alan/HLG-8927-2023; Butcher,
   Ken/AEP-3693-2022
OI Desmond, Patricia/0000-0002-4803-6323; Barber, P
   Alan/0000-0003-2469-9023; Colman, Peter/0000-0001-8718-6175; Butcher,
   Ken/0000-0002-0590-7918
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NR 116
TC 115
Z9 137
U1 1
U2 8
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0967-5868
EI 1532-2653
J9 J CLIN NEUROSCI
JI J. Clin. Neurosci.
PD NOV
PY 2002
VL 9
IS 6
BP 618
EP 626
DI 10.1054/jocn.2002.1081
PG 9
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 620CY
UT WOS:000179516900002
PM 12604269
DA 2025-06-11
ER

PT J
AU Papachatzakis, I
   Velentza, L
   Zarogoulidis, P
   Kallianos, A
   Trakada, G
AF Papachatzakis, I.
   Velentza, L.
   Zarogoulidis, P.
   Kallianos, A.
   Trakada, G.
TI Comorbidities in coexisting chronic obstructive pulmonary disease and
   obstructive sleep apnea - overlap syndrome
SO EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
LA English
DT Article
DE Chronic Obstructive Pulmonary Disease (COPD); Obstructive Sleep Apnea
   (OSA); Overlap syndrome; Comorbidities; Cardiometabolic risk
ID COPD; PREVALENCE; HYPERTENSION; ASSOCIATION; MANAGEMENT; DISORDERS;
   DIAGNOSIS; OBESITY; ADULTS
AB OBJECTIVE: Chronic Obstructive Pulmonary Disease (COPD) and Obstructive Sleep Apnea (OSA) are separately associated with several comorbidities. The coexistence of the two diseases. referred to as overlap syndrome. may act as a predisposing factor for a higher prevalence of comorbidities compared to those associated with each disease separately. The objective of the study was to evaluate the relative prevalence of cardiovascular as well as other comorbidities, in patients with the overlap syndrome, as compared to patients that are diagnosed solely with OSA.
   PATIENTS AND METHODS: We examined thirty-eight (38) patients (27 men, 11 women) with coexisting COPD and OSA - overlap syndrome (Group 1) vs. 38 patients with OSA-only (Group 2). matched for sex, age, and Body Mass Index (BMI). All patients underwent pulmonary function tests (PFTs), oximetry and overnight polysomnography and were asked about other coexisting chronic diseases and medications.
   RESULTS: The two groups differed significantly, as expected, in PFTs (Forced Vital Capacity - FVC. p=0.005. Forced Expiratory Volume in 1 s - FEV1 , p<0.001) and in daytime oximetry (p=0.007). Three (3) overlap (7.89%) and 9 OSA patients (23.69%) had no other known diseases. All others suffered from 1 - >= 4 comorbidities. Overlap patients suffered more often from multiple (>= 4) comorbidities than OSA-only patients (11, 28.95% vs. 4, 10.52%, respectively). The most common coexisting diseases were hypertension (50% vs. 42.1%), cardiovascular disease (CVD) (44.74% vs. 26.31%), diabetes mellitus (DM) (28.95% vs. 13.16%), dyslipidemia (21.05% vs. 26.31%) and depression (7.89% vs. 13.16%).
   CONCLUSIONS: We conclude that comorbidities, especially cardiovascular, in patients with overlap syndrome are at least as prevalent as in sleep apneic only patients and may contribute to the overall severity and prognosis of the disease.
C1 [Papachatzakis, I.; Velentza, L.; Kallianos, A.; Trakada, G.] Univ Athens, Alexandra Hosp, Sch Med, Dept Clin Therapeut,Div Pulmonol, Athens, Greece.
   [Zarogoulidis, P.] Aristotle Univ Thessaloniki, G Papanikolaou Gen Hosp, Pulmonary Dept, Oncol Unit, Thessaloniki, Greece.
C3 Alexandra Hospital; National & Kapodistrian University of Athens; Athens
   Medical School; Aristotle University of Thessaloniki; George
   Papanikolaou General Hospital of Thessaloniki
RP Trakada, G (corresponding author), Univ Athens, Alexandra Hosp, Sch Med, Dept Clin Therapeut,Div Pulmonol, Athens, Greece.
EM gtrakada@hotmail.com
RI Trakada, Georgia/S-3844-2019
OI Trakada, Georgia/0000-0003-0037-1269; Zarogoulidis,
   Paul/0000-0001-5119-2207
CR [Anonymous], report 2020-11-01
   [Anonymous], 2014, INT CLASSLEEP DIS
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NR 29
TC 22
Z9 24
U1 0
U2 6
PU VERDUCI PUBLISHER
PI ROME
PA VIA GREGORIO VII, ROME, 186-00165, ITALY
SN 1128-3602
J9 EUR REV MED PHARMACO
JI Eur. Rev. Med. Pharmacol. Sci.
PD JUL
PY 2018
VL 22
IS 13
BP 4325
EP 4331
PG 7
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA GN6HU
UT WOS:000439180600035
PM 30024626
DA 2025-06-11
ER

PT J
AU Alidadi, M
   Jamialahmadi, T
   Cicero, AFG
   Bianconi, V
   Pirro, M
   Banach, M
   Sahebkar, A
AF Alidadi, Mona
   Jamialahmadi, Tannaz
   Cicero, Arrigo F. G.
   Bianconi, Vanessa
   Pirro, Matteo
   Banach, Maciej
   Sahebkar, Amirhossein
TI The potential role of plant-derived natural products in improving
   arterial stiffness: A review of dietary intervention studies
SO TRENDS IN FOOD SCIENCE & TECHNOLOGY
LA English
DT Review
DE Phytochemical; Vascular elasticity; Natural products
ID RANDOMIZED CONTROLLED-TRIAL; SYSTEMIC OXIDATIVE STRESS; AGED GARLIC
   EXTRACT; FATTY LIVER-DISEASE; PULSE-WAVE VELOCITY; BLOOD-PRESSURE;
   ENDOTHELIAL FUNCTION; DOUBLE-BLIND; POSTMENOPAUSAL WOMEN; METABOLIC
   SYNDROME
AB Background: Arterial stiffness is an early marker of cardiovascular disease. In fact, carotid-femoral pulse wave velocity, the gold standard method for the evaluation of arterial stiffness, has a positive correlation with cardiovascular events and mortality. A number of studies have shown that the consumption of different phytochemicals and plant-derived natural foods can improve arterial elasticity through various molecular mechanisms.
   Scope and approach: The principal purpose of this review was to provide a summary of the clinical evidence provided by different interventional studies on the potential beneficial effects of some natural products and nutraceuticals on arterial stiffness.
   Key findings and conclusions: There is evidence that some foods and food components, including cocoa flavanols, tea, watermelon, grapefruit, grape juice, berries, cherries, apples, psyllium, tomatoes, garlic, beetroot, melinja, pistachio, walnut, astaxanthin, curcumin, and safflower seeds assumption are associated with significant improvements in arterial stiffness in both healthy subjects and subjects with mildly increased cardiovascular disease risk. Further studies are needed to confirm these promising data.
C1 [Alidadi, Mona] Mashhad Univ Med Sci, Sch Med, Mashhad, Razavi Khorasan, Iran.
   [Jamialahmadi, Tannaz] Halal Res Ctr IRI, FDA, Tehran, Iran.
   [Jamialahmadi, Tannaz] Mashhad Univ Med Sci, Fac Med, Dept Nutr, Mashhad, Razavi Khorasan, Iran.
   [Cicero, Arrigo F. G.] Alma Mater Studiorum Univ Bologna, Dept Med & Surg Sci, Bologna, Italy.
   [Bianconi, Vanessa; Pirro, Matteo] Univ Perugia, Dept Med, Unit Internal Med, Perugia, Italy.
   [Banach, Maciej] Med Univ Lodz, WAM Univ Hosp Lodz, Dept Hypertens, Zeromskiego 113, Lodz, Poland.
   [Banach, Maciej] PMMHRI, Lodz, Poland.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Neurogen Inflammat Res Ctr, Mashhad, Razavi Khorasan, Iran.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Biotechnol Res Ctr, Mashhad, Razavi Khorasan, Iran.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Sch Pharm, Mashhad, Razavi Khorasan, Iran.
C3 Mashhad University of Medical Sciences; Mashhad University of Medical
   Sciences; University of Bologna; University of Perugia; Medical
   University Lodz; Mashhad University of Medical Sciences; Mashhad
   University of Medical Sciences; Mashhad University of Medical Sciences
RP Sahebkar, A (corresponding author), Mashhad Univ Med Sci, Sch Med, Dept Med Biotechnol, POB 91779-48564, Mashhad, Razavi Khorasan, Iran.
EM sahebkara@mums.ac.ir
RI Sahebkar, Amirhossein/B-5124-2018; Banach, Maciej/A-1271-2009; Pirro,
   Matteo/AAC-2318-2022; Cicero, Arrigo/H-8244-2019; Bianconi,
   Vanessa/AAC-2058-2019
OI Jami, Tannaz/0000-0001-9521-3153; Pirro, Matteo/0000-0002-5527-4821;
   Bianconi, Vanessa/0000-0001-6987-9349; Cicero, Arrigo Francesco
   Giuseppe/0000-0002-4367-3884
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NR 123
TC 43
Z9 44
U1 1
U2 36
PU ELSEVIER SCIENCE LONDON
PI LONDON
PA 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND
SN 0924-2244
EI 1879-3053
J9 TRENDS FOOD SCI TECH
JI Trends Food Sci. Technol.
PD MAY
PY 2020
VL 99
BP 426
EP 440
DI 10.1016/j.tifs.2020.03.026
PG 15
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA LE4WD
UT WOS:000526719400034
DA 2025-06-11
ER

PT J
AU Adigun, NS
   Oladiji, AT
   Ajiboye, TO
AF Adigun, Nurudeen S.
   Oladiji, A. Temidayo
   Ajiboye, Taofeek O.
TI Hydro-Ethanolic Fruit Extract of Capsicum frutescens Reversed
   Triton-X-100-Induced Hyperlipidaemia in Rats
SO JOURNAL OF DIETARY SUPPLEMENTS
LA English
DT Article
DE antioxidants; atorvastatin; capsicum frutescens; hyperlipidaemia; lipid
   profile; triton X-100
ID OXYGEN SPECIES DETOXIFICATION; INDUCED METABOLIC SYNDROME; ANTIOXIDANT
   ACTIVITY; HYPERCHOLESTEROLEMIC ATHEROSCLEROSIS; INSULIN-RESISTANCE;
   SERUM-CHOLESTEROL; OXIDATIVE STRESS; SEED EXTRACT; LEAVES; HYPERGLYCEMIA
AB This study evaluates the anti-hyperlipidaemic and antioxidant activities of hydro-ethanolic fruits extract of Capsicum frutescens in hyperlipidemia rats. The secondary volatile metabolite constituents of the extract were identified using Gas chromatography. In vitro antioxidant activity of the extract (0.2-1.0 mg/mL) was investigated using 2, 2-diphenyl-1-picrylhydrazyl (DPPH) radical, hydrogen peroxide (H2O2) and hydroxyl radical (OH.). In vivo antioxidant and anti-hyperlipidaemic properties of the extract were evaluated in triton X-100-induced hyperlipidaemic rats. Gas chromatogram indicates the presence of 13 compounds with tans beta-ocimene being the major constituent. The extract scavenged DPPH, H2O2 and OH. radicals in concentrations dependent manner. C. frutescens reversed triton X-100-mediated increase in serum total cholesterol, triglycerides and low-density lipoprotein, and reduction in high-density lipoprotein. Triton X-100-mediated decrease in superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase and glucose 6-phospahte dehydrogenase were significantly reversed by the extract. The results indicate that C. frutescens has antioxidant and anti-hyperlipidaemic properties.
C1 [Adigun, Nurudeen S.; Oladiji, A. Temidayo] Univ Ilorin, Dept Biochem, Ilorin, Nigeria.
   [Ajiboye, Taofeek O.] Nile Univ Nigeria, Coll Hlth Sci, Dept Med Biochem, Antioxidants Redox Biol & Toxicol Res Grp, Fct Abuja, Nigeria.
C3 University of Ilorin
RP Ajiboye, TO (corresponding author), Nile Univ Nigeria, Coll Hlth Sci, Dept Med Biochem, Antioxidants Redox Biol & Toxicol Res Grp, Fct Abuja, Nigeria.
EM ajiboyeyong@gmail.com
RI Ajiboye, Taofeek/H-5383-2011
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TC 8
Z9 10
U1 0
U2 5
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1939-0211
EI 1939-022X
J9 J DIET SUPPL
JI J. Diet. Suppl.
PD JAN 2
PY 2020
VL 17
IS 1
BP 53
EP 66
DI 10.1080/19390211.2018.1482982
PG 14
WC Nutrition & Dietetics; Pharmacology & Pharmacy
WE Emerging Sources Citation Index (ESCI)
SC Nutrition & Dietetics; Pharmacology & Pharmacy
GA JZ5KO
UT WOS:000505140800005
PM 30451048
DA 2025-06-11
ER

PT J
AU Peto, A
   Kósa, D
   Fehér, P
   Ujhelyi, Z
   Sinka, D
   Vecsernyés, M
   Szilvássy, Z
   Juhász, B
   Csanádi, Z
   Vígh, L
   Bácskay, I
AF Peto, Agota
   Kosa, Dora
   Feher, Palma
   Ujhelyi, Zoltan
   Sinka, David
   Vecsernyes, Miklos
   Szilvassy, Zoltan
   Juhasz, Bela
   Csanadi, Zoltan
   Vigh, Laszlo
   Bacskay, Ildiko
TI Pharmacological Overview of the BGP-15 Chemical Agent as a New Drug
   Candidate for the Treatment of Symptoms of Metabolic Syndrome
SO MOLECULES
LA English
DT Review
DE BGP-15; chaperone co-inducer; PARP inhibitor; insulin sensitizer
ID CO-INDUCER BGP-15; IN-VITRO MODEL; PERIPHERAL NEUROPATHY; INSULIN
   SENSITIVITY; DOUBLE-BLIND; CELL; DYSFUNCTION; PROTECTS; PREVENT; HEART
AB BGP-15 is a new insulin sensitizer drug candidate, which was developed by Hungarian researchers. In recent years, numerous research groups have studied its beneficial effects. It is effective in the treatment of insulin resistance and it has protective effects in Duchenne muscular dystrophy, diastolic dysfunction, tachycardia, heart failure, and atrial fibrillation, and it can alleviate cardiotoxicity. BGP-15 exhibits chemoprotective properties in different cytostatic therapies, and has also proven to be photoprotective. It can additionally have advantageous effects in mitochondrial-stress-related diseases. Although the precise mechanism of the effect is still unknown to us, we know that the molecule is a PARP inhibitor, chaperone co-inducer, reduces ROS production, and is able to remodel the organization of cholesterol-rich membrane domains. In the following review, our aim was to summarize the investigated molecular mechanisms and pharmacological effects of this potential API. The main objective was to present the wide pharmacological potentials of this chemical agent.
C1 [Peto, Agota; Kosa, Dora; Feher, Palma; Ujhelyi, Zoltan; Sinka, David; Vecsernyes, Miklos; Bacskay, Ildiko] Univ Debrecen, Fac Pharm, Dept Pharmaceut Technol, Egyet Ter 1, H-4032 Debrecen, Hungary.
   [Szilvassy, Zoltan; Juhasz, Bela] Univ Debrecen, Fac Med, Dept Pharmacol & Pharmacotherapy, Nagyerdei Korut 98, H-4032 Debrecen, Hungary.
   [Csanadi, Zoltan] Univ Debrecen, Inst Cardiol, Moricz Zsigmond Korut 22, H-4032 Debrecen, Hungary.
   [Vigh, Laszlo] Hungarian Acad Sci, Biol Res Ctr, Temesvari Korut 62, H-6726 Szeged, Hungary.
C3 University of Debrecen; University of Debrecen; University of Debrecen;
   Hungarian Academy of Sciences; HUN-REN; HUN-REN Biological Research
   Center
RP Bácskay, I (corresponding author), Univ Debrecen, Fac Pharm, Dept Pharmaceut Technol, Egyet Ter 1, H-4032 Debrecen, Hungary.
EM peto.agota@pharm.unideb.hu; kosa.dora@pharm.unideb.hu;
   feher.palma@pharm.unideb.hu; ujhelyi.zoltan@pharm.unideb.hu;
   sinka.david@pharm.unideb.hu; vecsernyes.miklos@pharm.unideb.hu;
   szilvassy.zoltan@med.unideb.hu; juhasz.bela@med.unideb.hu;
   csanadi.zoltan@med.unideb.hu; vigh@brc.hu;
   bacskay.ildiko@pharm.unideb.hu
RI Ujhelyi, Zoltan/AAF-7036-2021
OI Ujhelyi PharmD PhD, Zoltan/0000-0001-9724-0614
FU Higher Education Institutional Excellence Programme of the Ministry of
   Human Capacities in Hungary, within the framework of the Research and
   Development on Therapeutic Purposes Thematic Programme of the University
   of Debrecen [NKFIH-1150-6/2019]; European Union; European Social Fund;
   Richter Gedeon Talent foundation;  [EFOP-3.6.1-16-2016-00022]
FX The research was financed by the Higher Education Institutional
   Excellence Programme of the Ministry of Human Capacities in Hungary,
   within the framework of the Research and Development on Therapeutic
   Purposes Thematic Programme of the University of Debrecen
   (NKFIH-1150-6/2019). The work is also supported by the
   EFOP-3.6.1-16-2016-00022 project. The project is co-financed by the
   European Union and the European Social Fund. The research was
   co-financed by the Richter Gedeon Talent foundation.
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NR 54
TC 28
Z9 28
U1 0
U2 11
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1420-3049
J9 MOLECULES
JI Molecules
PD JAN 2
PY 2020
VL 25
IS 2
AR 429
DI 10.3390/molecules25020429
PG 13
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA KO2LR
UT WOS:000515381800190
PM 31968693
OA Green Accepted, gold, Green Published
DA 2025-06-11
ER

PT J
AU Martínez, R
   Kapravelou, G
   Porres, JM
   Melesio, AM
   Heras, L
   Cantarero, S
   Gribble, FM
   Parker, H
   Aranda, P
   López-Jurado, M
AF Martinez, Rosario
   Kapravelou, Garyfallia
   Porres, Jesus M.
   Melesio, Adela M.
   Heras, Leticia
   Cantarero, Samuel
   Gribble, Fiona M.
   Parker, Helen
   Aranda, Pilar
   Lopez-Jurado, Maria
TI Medicago sativa L., a functional food to relieve hypertension and
   metabolic disorders in a spontaneously hypertensive rat model
SO JOURNAL OF FUNCTIONAL FOODS
LA English
DT Article
DE Alfalfa; Blood pressure; Polyphenols; Fatty liver; Glucagon-like
   peptide-1; Spontaneously hypertensive rat
ID GLUTATHIONE-PEROXIDASE-ACTIVITY; FATTY LIVER-DISEASE; BLOOD-PRESSURE;
   OXIDATIVE STRESS; ALFALFA; PEPTIDE; INSULIN; GLUCOSE; PLANT; LINK
AB Medicago saliva L. (alfalfa) is a leguminous plant with beneficial effects on altered glucose and lipid metabolism, moreover exhibiting hypotensive activity. We improved the functional properties of alfalfa, growing the plant under specific soil conditions of high salinity. We determined the main bioactive compounds and five new phenolic compounds were identified. Alfalfa grown under high salinity conditions was added to experimental diets and assayed in an experimental model of spontaneously hypertensive rat. Among the main findings, a slight decrease on blood pressure, a reduction in the risk of kidney stone formation, a protective action against oxidative damage in fatty liver disease, as well as an improvement of glucose metabolism through the normalization of the gcg expression in colon should be underlined. Alfalfa can be used as an efficient functional food for the dietary prevention and treatment of several metabolic alterations, characteristic of the metabolic syndrome. Crown Copyright (C) 2016 Published by Elsevier Ltd. All rights reserved.
C1 [Martinez, Rosario; Kapravelou, Garyfallia; Porres, Jesus M.; Melesio, Adela M.; Heras, Leticia; Aranda, Pilar; Lopez-Jurado, Maria] Univ Granada, Ctr Biomed Res, Inst Nutr & Food Technol, Dept Physiol,Fac Pharm, Campus Univ Cartuja,S-N, E-18071 Granada, Spain.
   [Cantarero, Samuel] Univ Granada, Ctr Instrumentac Cient, Campus Univ Fuentenueva,S-N, E-18071 Granada, Spain.
   [Gribble, Fiona M.; Parker, Helen] Univ Cambridge, Wellcome Trust MRC Inst Metab Sci, Hills Rd, Cambridge CB2 0QQ, England.
C3 University of Granada; University of Granada; University of Cambridge
RP Martínez, R (corresponding author), Univ Granada, Fac Farm, Dept Fisiol, Campus Univ Cartuja S-N, E-18071 Granada, Spain.
EM rosario.mzmz@gmail.com
RI Porres Foulquie, Jesus Maria/B-6442-2018; Kapravelou,
   Garyfallia/K-8635-2017; Martinez, Rosario/K-7712-2017; Aranda Ramirez,
   Pilar/B-8037-2016; Cantarero Malagon, Antonio Samuel/C-3258-2017
OI Porres Foulquie, Jesus Maria/0000-0001-5657-0764; Kapravelou,
   Garyfallia/0000-0001-8414-9723; Martinez, Rosario/0000-0003-2032-1621;
   Aranda Ramirez, Pilar/0000-0002-7982-1359; Gribble,
   Fiona/0000-0002-4232-2898; Cantarero Malagon, Antonio
   Samuel/0000-0002-3716-0070
FU Junta de Andalucia, Spain [P07-AGR-2704, P09AGR-4658]; FEDER program
   [AGL2013-43247-R]; Cambridge Institute for Medical Research; MRC
   [MC_UU_12012/3] Funding Source: UKRI
FX This study was funded by Grants P07-AGR-2704 and P09AGR-4658 from Junta
   de Andalucia, Spain. The authors want to acknowledge the Ministry of
   Economy and Competitiveness (MINECO, Spain), the European Union and
   FEDER program through project no AGL2013-43247-R. Gene expression work
   was carried out at Cambridge University and was funded by the Cambridge
   Institute for Medical Research.
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NR 79
TC 19
Z9 19
U1 0
U2 19
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1756-4646
EI 2214-9414
J9 J FUNCT FOODS
JI J. Funct. Food.
PD OCT
PY 2016
VL 26
BP 470
EP 484
DI 10.1016/j.jff.2016.08.013
PG 15
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA DZ9KG
UT WOS:000386193400043
DA 2025-06-11
ER

PT J
AU Luk, A
   Chan, JCN
AF Luk, Andrea
   Chan, Juliana C. N.
TI Diabetic nephropathy-What are the unmet needs?
SO DIABETES RESEARCH AND CLINICAL PRACTICE
LA English
DT Article; Proceedings Paper
CT International Symposium on Diabetic Nephropathy
CY 2008
CL Shiga, JAPAN
DE Diabetes; Obesity; End stage renal disease
ID ALL-CAUSE MORTALITY; CHRONIC KIDNEY-DISEASE; STAGE RENAL-DISEASE;
   BLOOD-CELL COUNT; METABOLIC SYNDROME; CHINESE PATIENTS; RISK SCORE;
   MICROVASCULAR COMPLICATIONS; CARDIOVASCULAR-DISEASE; HEART-DISEASE
AB In this pandemic of diabetes and obesity, Asia will have the highest number of affected people with the greatest increase in the young-to-middle aged group. Asian patients have increased risk for diabetic kidney disease which maybe compounded by low grade infection, obesity and genetic factors, In these subjects, the onset of albuminuria and diabetic kidney disease causes further perturbation of metabolic milieu with increased oxidative stress, anaemia and vascular calcification which interact to markedly increase the risk of cardiovascular disease. Despite receiving optimal care to control blood pressure and metabolic risk factors as well as inhibition of the renin-angiotensin system in a clinical trial setting, there is a considerable residual risk for cardio-renal complications in patients with diabetic kidney disease. Control of obesity and low grade inflammation as well as correction of anaemia may represent areas where novel strategies can be developed and tested to curb this rising global burden of cardio-renal complications. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
C1 [Luk, Andrea; Chan, Juliana C. N.] Chinese Univ Hong Kong, Prince Wales Hosp, Dept Med & Therapeut, Shatin, Hong Kong, Peoples R China.
   [Chan, Juliana C. N.] Chinese Univ Hong Kong, Prince Wales Hosp, Hong Kong Inst Diabet & Obes, Shatin, Hong Kong, Peoples R China.
C3 Chinese University of Hong Kong; Prince of Wales Hospital; Chinese
   University of Hong Kong; Prince of Wales Hospital
RP Chan, JCN (corresponding author), Chinese Univ Hong Kong, Prince Wales Hosp, Dept Med & Therapeut, Shatin, Hong Kong, Peoples R China.
EM jchan@cuhk.edu.hk
RI Luk, Andrea/B-5766-2016; Chan, Juliana/B-7918-2016
OI Chan, Juliana/0000-0003-1325-1194
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NR 68
TC 25
Z9 29
U1 0
U2 2
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0168-8227
EI 1872-8227
J9 DIABETES RES CLIN PR
JI Diabetes Res. Clin. Pract.
PD NOV 13
PY 2008
VL 82
SU 1
BP S15
EP S20
DI 10.1016/j.diabres.2008.09.033
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Endocrinology & Metabolism
GA 381RM
UT WOS:000261553600004
PM 18952313
DA 2025-06-11
ER

PT J
AU Tawa, M
   Nakagawa, K
   Ohkita, M
AF Tawa, Masashi
   Nakagawa, Keisuke
   Ohkita, Mamoru
TI Soluble guanylate cyclase stimulators and activators as potential
   antihypertensive drugs
SO HYPERTENSION RESEARCH
LA English
DT Review
DE Soluble guanylate cyclase; sGC activators; sGC stimulators; hypertension
ID DEPENDENT PROTEIN-KINASE; NITRIC-OXIDE; INDEPENDENT ACTIVATION; ORGAN
   DAMAGE; BAY 41-2272; OXIDATIVE STRESS; NO; HYPERTENSION; PROGRESSION;
   MODEL
AB Poor blood pressure control in treated patients with hypertension is an important topic in the field of hypertension, and an unmet need for new therapeutic drugs remains. Soluble guanylate cyclase (sGC), a key signal transduction enzyme responsible for vasodilation, has attracted increasing interest as a therapeutic target in various cardiovascular diseases. Two different sGC agonists, sGC stimulators and activators, can increase its enzymatic activity in reduced and oxidized/apo forms, respectively. With some sGC agonists being already in clinical use, drugs in this category are expected to become new therapeutic agents for various conditions, including hypertension. In this review, we summarize the current knowledge on the antihypertensive effects of sGC agonists in various preclinical studies involving animal models of spontaneous hypertension, salt-sensitive hypertension, nitric oxide-deficient hypertension, renin-angiotensin-aldosterone system-dependent hypertension, malignant hypertension, metabolic syndrome, renoprival hypertension, renovascular hypertension, drug-induced hypertension, pregnancy hypertension, and treatment-resistant hypertension. Our compilation provides a comprehensive rationale for advancing the clinical development of sGC agonists for the treatment of hypertension.
C1 [Tawa, Masashi; Nakagawa, Keisuke; Ohkita, Mamoru] Osaka Med & Pharmaceut Univ, Fac Pharm, Dept Pathol & Mol Pharmacol, Takatsuki, Osaka, Japan.
C3 Osaka Medical & Pharmaceutical University
RP Tawa, M (corresponding author), Osaka Med & Pharmaceut Univ, Fac Pharm, Dept Pathol & Mol Pharmacol, Takatsuki, Osaka, Japan.
EM masashi.tawa@ompu.ac.jp
FU Japan Society for the Promotion of Science [22K15299]
FX This study was supported in part by the Grants-in-Aid for Scientific
   Research Program from the Japan Society for the Promotion of Science
   (grant number 22K15299 to M.T.). We would like to thank Editage
   (www.editage.jp) for English language editing.
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NR 77
TC 1
Z9 1
U1 7
U2 7
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0916-9636
EI 1348-4214
J9 HYPERTENS RES
JI Hypertens. Res.
PD APR
PY 2025
VL 48
IS 4
BP 1458
EP 1470
DI 10.1038/s41440-025-02110-5
EA JAN 2025
PG 13
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 1BB8N
UT WOS:001400832600001
PM 39833553
DA 2025-06-11
ER

PT J
AU Munari, EV
   Amer, M
   Amodeo, A
   Bollino, R
   Federici, S
   Goggi, G
   Giovanelli, L
   Persani, L
   Cangiano, B
   Bonomi, M
AF Munari, Elisabetta Veronica
   Amer, Myriam
   Amodeo, Alessandro
   Bollino, Ruggiero
   Federici, Silvia
   Goggi, Giovanni
   Giovanelli, Luca
   Persani, Luca
   Cangiano, Biagio
   Bonomi, Marco
TI The complications of male hypogonadism: is it just a matter of low
   testosterone?
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Review
DE osteoporosis; endothelial dysfunction; cardiovascular events;
   hypogonadism; complications
ID BONE-MINERAL DENSITY; ENDOTHELIAL PROGENITOR CELLS;
   FOLLICLE-STIMULATING-HORMONE; INSULIN-LIKE FACTOR-3;
   KLINEFELTER-SYNDROME; ANDROGEN RECEPTOR; METABOLIC SYNDROME; REDUCED
   NUMBER; RISK-FACTOR; MEN
AB The history of diagnosing hypogonadism and hypotestosteronemia shows us the many steps that were necessary to achieve our current knowledge and the ability to improve these patients' well-being. Moreover, so far, criteria for diagnosing hypotestosteronemia varies according to the underlying condition, and according to the consensus or guideline adopted. Furthermore, besides the many signs and symptoms, there are several complications associated with low testosterone levels such as osteoporosis, metabolic alterations, as well as cardiovascular disorders. However, data are often conflicting regarding the severity, timing or even the real clinical relevance of these complications, although these studies often lack essential information such as gonadotropin levels or the underlying cause of hypogonadism. The present review focus on the complications of male hypogonadism according to the cause of testosterone deficiency, highlighting the lack of information found in many studies investigating its effects. We thereby stress the necessity to always perform a complete evaluation of the type of hypogonadism (including at least gonadotropins and secondary causes) when investigating the effects of low testosterone levels.
C1 [Munari, Elisabetta Veronica; Amer, Myriam; Amodeo, Alessandro; Bollino, Ruggiero; Federici, Silvia; Giovanelli, Luca; Persani, Luca; Cangiano, Biagio; Bonomi, Marco] Univ Milan, Dept Med Biotechnol & Translat Med, Milan, Italy.
   [Goggi, Giovanni; Persani, Luca; Cangiano, Biagio; Bonomi, Marco] IRCCS Ist Auxol Italiano, Dept Endocrine & Metab Dis, Milan, Italy.
C3 University of Milan; IRCCS Istituto Auxologico Italiano
RP Cangiano, B (corresponding author), Univ Milan, Dept Med Biotechnol & Translat Med, Milan, Italy.; Cangiano, B (corresponding author), IRCCS Ist Auxol Italiano, Dept Endocrine & Metab Dis, Milan, Italy.
EM b.cangiano@auxologico.it
RI Goggi, Giovanni/LSK-6475-2024; Amodeo, Alessandro/KII-7393-2024;
   Federici, Silvia/HKO-1438-2023; Bonomi, Marco/A-3285-2009; Cangiano,
   Biagio/K-1236-2018; Persani, Luca/B-6543-2008
OI Goggi, Giovanni/0000-0003-3141-468X; Bonomi, Marco/0000-0001-5454-6074;
   Cangiano, Biagio/0000-0002-2658-744X; Persani, Luca/0000-0003-2068-9581
FU Italian Ministry of Health [05C622_2016]
FX This paper was partially supported by Ricerca Corrente funds from
   Italian Ministry of Health to IRCCS Istituto Auxologico Italiano (fund:
   05C622_2016).
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NR 106
TC 8
Z9 8
U1 0
U2 6
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD JUN 28
PY 2023
VL 14
AR 1201313
DI 10.3389/fendo.2023.1201313
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA L9PS1
UT WOS:001026520900001
PM 37455904
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Xie, ZQ
   Yao, MH
   Castro-Mejía, JL
   Ma, M
   Zhu, YY
   Fu, X
   Huang, Q
   Zhang, B
AF Xie, Zhuqing
   Yao, Minghua
   Castro-Mejia, Josue L.
   Ma, Ming
   Zhu, Yuyan
   Fu, Xiong
   Huang, Qiang
   Zhang, Bin
TI Propionylated high-amylose maize starch alleviates obesity by modulating
   gut microbiota in high-fat diet-fed mice
SO JOURNAL OF FUNCTIONAL FOODS
LA English
DT Article
DE Propionylated high-amylose maize starch; High-fat diet; Propionate; Gut
   microbiota
ID RS4-TYPE RESISTANT STARCH; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   OXIDATIVE STRESS; ASSOCIATION; BUTYRATE; SERUM; ACIDS; FERMENTATION;
   INFLAMMATION
AB Obesity threatens human health worldwide, and mounting findings have found that gut microbiota (GM) changes induced by diet intervention influence its development. This study aims to investigate the anti-obesity effects and GM changes of propionylated high-amylose maize starch (PS) in C57BL/6J mice fed with high-fat diet (HFD). In our results, PS decreased the body weight of HFD-fed mice after 8 weeks and regulated the glucose stability and insulin resistance. High-amylose maize starch (HAMS) and PS regulated the serum lipid levels and inflammatory response. Moreover, PS yielded more propionate relative to HAMS, proving that introduced propionyl groups could be released in the colon. 16S rRNA results showed that PS altered GM with the increase of bacteria (S24-7 and Ruminococcus) and decrease of harmful genera, which is linked to the anti-obesity effect. Our results provide a reference for the design of functional dietary fibers inducing high propionate production and GM modulation.
C1 [Xie, Zhuqing; Huang, Qiang; Zhang, Bin] South China Univ Technol, Sch Food Sci & Engn, Guangdong Prov Key Lab Green Proc Nat Prod & Prod, Guangzhou 510640, Peoples R China.
   [Xie, Zhuqing] Univ Copenhagen, Dept Food Sci, Rolighedsvej 26, DK-1958 Frederiksberg C, Denmark.
   [Yao, Minghua] Shanghai Jiao Tong Univ, Shanghai Gen Hosp, Sch Med, Shanghai 200080, Peoples R China.
   [Ma, Ming] Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China.
   [Zhu, Yuyan] Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Hung Hom, Kowloon, Hong Kong, Peoples R China.
   [Zhang, Bin] South China Univ Technol, Overseas Expertise Intro Ctr Discipline Innovat F, Guangzhou 510640, Peoples R China.
C3 South China University of Technology; University of Copenhagen; Shanghai
   Jiao Tong University; Chinese Academy of Sciences; Shanghai Institute of
   Ceramics, CAS; Hong Kong Polytechnic University; South China University
   of Technology
RP Zhang, B (corresponding author), South China Univ Technol, Sch Food Sci & Engn, Guangdong Prov Key Lab Green Proc Nat Prod & Prod, Guangzhou 510640, Peoples R China.; Yao, MH (corresponding author), Shanghai Jiao Tong Univ, Shanghai Gen Hosp, Sch Med, Shanghai 200080, Peoples R China.
EM yaominghua115@163.com; zhangb@scut.edu.cn
RI Huang, Qiang/ACF-7958-2022; Xie, Zhuqing/LOR-2853-2024; Zhang,
   Bin/AAW-5334-2021; Ma, Ming/J-1833-2015; Castro-Mejia, Josue/P-5649-2014
OI Xie, Zhuqing/0000-0002-8323-4472
FU National Natural Science Foundation of China [82171951]; Distinguished
   Overseas Experts Pro- gram of Guangdong Province; 111 Project [B17018]
FX This work was supported by the National Natural Science Foundation of
   China (Grants No. 82171951) , Distinguished Overseas Experts Pro- gram
   of Guangdong Province, and the 111 Project (B17018) .
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NR 64
TC 8
Z9 8
U1 6
U2 48
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1756-4646
EI 2214-9414
J9 J FUNCT FOODS
JI J. Funct. Food.
PD MAR
PY 2023
VL 102
AR 105447
DI 10.1016/j.jff.2023.105447
EA FEB 2023
PG 10
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA 9P8XN
UT WOS:000944561400001
OA gold
DA 2025-06-11
ER

PT J
AU Durkovicova, Z
   Faktorova, X
   Jakabovicova, M
   Szantova, M
AF Durkovicova, Zuzana
   Faktorova, Xenia
   Jakabovicova, Martina
   Szantova, Maria
TI Molecular mechanisms in the pathogenesis of metabolically associated
   fatty liver disease
SO BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY
LA English
DT Article
DE NASH; MAFLD; microbiome; lipotoxicity; bile acids; inflammasomes
ID NLRP3 INFLAMMASOME ACTIVATION; NONALCOHOLIC STEATOHEPATITIS; OBESE MICE;
   ER STRESS; RECEPTOR; CELLS; PERMEABILITY; TRIGLYCERIDE; CERAMIDES
AB Inflammation is a common feature of all chronic liver diseases and atherosclerosis. The article discusses the participation of cytokines and inflammasomes in the process of development of metabolically associated fatty liver disease (MAFLD) and the ways of their activation under the influence of inductive stimuli (toxins, alcohol, fat, viruses, etc.), most often in the case of disruption of intestinal permeability through toll-like receptors with an imbalance in the composition of intestinal microflora and bile acids. Inflammasomes and cytokines are the sources of sterile inflammation in the liver in obesity and metabolic syndrome with subsequent lipotoxicity which is followed by fibrogenesis. The prospects for therapeutic modulation of diseases with the participation of inflammasomes are therefore sought precisely at the level of influencing the mentioned molecular mechanisms. The article emphasizes the importance of the liver-intestinal axis and modulation of microbiome, as well as calls attention to the influence of the circadian rhythm of the 12-hour pacemaker on gene production in NASH (non-alcoholic steatohepatitis) developing (Fig. 4, Ref. 56). Text in PDF www.elis.sk
C1 [Durkovicova, Zuzana; Szantova, Maria] Comenius Univ, Fac Med, Dept Internal Med 3, Bratislava, Slovakia.
   [Durkovicova, Zuzana; Szantova, Maria] Univ Hosp Bratislava, Bratislava, Slovakia.
   [Faktorova, Xenia] St Michael Hosp, Dept Internal Med, Bratislava, Slovakia.
   [Jakabovicova, Martina] Gen Practitioner Off, Modra, Slovakia.
   [Durkovicova, Zuzana] Univ Hosp Bratislava, Dept Internal Med 3, Limbova 5, SK-83305 Bratislava, Slovakia.
C3 Comenius University Bratislava; Slovak Medical University Bratislava;
   Slovak Medical University Bratislava
RP Durkovicova, Z (corresponding author), Univ Hosp Bratislava, Dept Internal Med 3, Limbova 5, SK-83305 Bratislava, Slovakia.
EM zuz.sedlakova@gmail.com
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NR 56
TC 1
Z9 2
U1 2
U2 9
PU AEPRESS SRO
PI BRATISLAVA
PA BAJZOVA 7, BRATISLAVA, 821 08, SLOVAKIA
SN 0006-9248
EI 1336-0345
J9 BRATISL MED J
JI Bratisl. Med. J.
PY 2023
VL 124
IS 6
BP 427
EP 436
DI 10.4149/BLL_2023_065
PG 10
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA H2IQ5
UT WOS:000994256900004
PM 36876377
OA gold
DA 2025-06-11
ER

PT J
AU Sun, WL
   Shahrajabian, MH
   Cheng, Q
AF Sun, Wenli
   Shahrajabian, Mohamad Hesam
   Cheng, Qi
TI Barberry (Berberis vulgaris), a medicinal fruit and food with
   traditional and modern pharmaceutical uses
SO ISRAEL JOURNAL OF PLANT SCIENCES
LA English
DT Article
DE Barberry; Berberrine; Zereshk; traditional medicine; modern science
ID CHINESE MEDICINE; AQUEOUS EXTRACT; L. FRUITS; DIVERSITY; ENZYMES;
   QUALITY; STRESS; ROOT
AB Barberry is a resistant shrub which is able to grow up in semi-arid region with low-water or salty fields. Its red fruit widely used in Iranian foods because of its color and delicious taste. Berberis known as Zereshk in Persian has been consumed as both a remedy and traditional food additive. Its fruits are used mainly in Persian food in preparing juices, jam, chocolates, sauces and also a garniture. In both traditional and folkore medicine, it has been applied for its many biological and pharmacological activities. The most important compounds of B. Vulgaris are lupeol, oleanolic acid, stigmasterol, stigmasterolglucoside, berberamine, palmatine, berberine, oxyberberine, columbamine, isocorydie, lambertine, magniflorine, and oxycanthine. Barberry which are high in nutrients, contain beneficial plant compounds, which may help to manage diabetes, treat diarrhea, protect against metabolic syndrome, maintain dental health, and help fight acne. It also has anti-cancer effects, and it is appropriate to add to the diet. This review summarizes the beneficial effects of Barberry which is recommended for consumption.
C1 [Sun, Wenli; Shahrajabian, Mohamad Hesam; Cheng, Qi] Chinese Acad Agr Sci, Biotechnol Res Inst, Beijing 100081, Peoples R China.
   [Cheng, Qi] Hebei Agr Univ, Coll Life Sci, Baoding 071000, Hebei, Peoples R China.
   [Cheng, Qi] Global Alliance HeBAU, CLS&HeQiS BioAl Mfg, Baoding 071000, Hebei, Peoples R China.
C3 Chinese Academy of Agricultural Sciences; Biotechnology Research
   Institute, CAAS; Hebei Agricultural University
RP Cheng, Q (corresponding author), Chinese Acad Agr Sci, Biotechnol Res Inst, Beijing 100081, Peoples R China.; Cheng, Q (corresponding author), Hebei Agr Univ, Coll Life Sci, Baoding 071000, Hebei, Peoples R China.; Cheng, Q (corresponding author), Global Alliance HeBAU, CLS&HeQiS BioAl Mfg, Baoding 071000, Hebei, Peoples R China.
EM chengqi@caas.cn
RI Cheng, Qi/C-9922-2018; Sun, Wenli/HJY-5181-2023
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NR 129
TC 26
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PU BRILL
PI LEIDEN
PA PLANTIJNSTRAAT 2, P O BOX 9000, 2300 PA LEIDEN, NETHERLANDS
SN 0792-9978
EI 2223-8980
J9 ISR J PLANT SCI
JI Isr. J. Plant Sci.
PD SEP
PY 2021
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BP 61
EP 71
DI 10.1163/22238980-bja10019
PG 11
WC Plant Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences
GA WC1RE
UT WOS:000704040400002
DA 2025-06-11
ER

PT J
AU AlAmri, OD
   Albeltagy, RS
   Akabawy, AMA
   Mahgoub, S
   Abdel-Mohsen, DM
   Moneim, AEA
   Amin, HK
AF AlAmri, Ohoud D.
   Albeltagy, Rasha S.
   Akabawy, Ahmed M. A.
   Mahgoub, Shahenda
   Abdel-Mohsen, Doaa M.
   Moneim, Ahmed E. Abdel
   Amin, Hatem K.
TI Investigation of antioxidant and anti-inflammatory activities as well as
   the renal protective potential of green coffee extract in high
   fat-diet/streptozotocin-induced diabetes in male albino rats
SO JOURNAL OF FUNCTIONAL FOODS
LA English
DT Article
DE High-fat diet; STZ; Green coffee; Renal function; Apoptosis;
   Inflammation
ID OXIDATIVE STRESS; CHLOROGENIC ACID; APOPTOSIS; RISK; CONSUMPTION;
   MECHANISMS; AUTOPHAGY; GLUCOSE; LEVEL; MODEL
AB Green coffee consumption has been stated to have a converse association with type 2 diabetes and metabolic syndrome. Hence, we assessed changes produced by the administration of different doses of green coffee on biomarkers related to renal and antioxidant systems. The study was carried out on 42 diabetic male albino rats; a high-fat diet (HFD) and a single dose of streptozotocin (STZ; 35 mg kg(-1)) were utilized for model induction. Diabetic rats were received green coffee water extract (GCWE; 50 and 100 mg kg(-1)) daily for 28 days. GCWE caused a remarkable recovery of kidney weight, kidney function, and aldosterone level, particularly. Proapoptotic, antiapoptotic and inflammatory markers were significantly improved and showing a great retain to their normal levels specifically in GCWE-treated groups. Also, a marked improvement in the antioxidants defense system was noted. GCWE has a great protective influence on kidney injury of HFD/STZ-induced diabetic rats.
C1 [AlAmri, Ohoud D.] King Saud Univ, Fac Sci, Dept Zool, Riyadh, Saudi Arabia.
   [Albeltagy, Rasha S.; Moneim, Ahmed E. Abdel] Helwan Univ, Fac Sci, Dept Zool & Entomol, Cairo, Egypt.
   [Akabawy, Ahmed M. A.; Mahgoub, Shahenda; Abdel-Mohsen, Doaa M.; Amin, Hatem K.] Helwan Univ, Fac Pharm, Dept Biochem & Mol Biol, Cairo, Egypt.
C3 King Saud University; Egyptian Knowledge Bank (EKB); Helwan University;
   Egyptian Knowledge Bank (EKB); Helwan University
RP AlAmri, OD (corresponding author), King Saud Univ, Fac Sci, Dept Zool, Riyadh, Saudi Arabia.; Moneim, AEA (corresponding author), Helwan Univ, Fac Sci, Dept Zool & Entomol, Cairo, Egypt.
EM ohalamri@ksu.edu.sa; ahmed_abdelmoneim@science.helwan.edu.eg
RI Amin, Hatem/AAB-4554-2019; Abdel Mohsen, Doaa/ABG-2151-2021; Moneim,
   Ahmed/C-7461-2012; Elbeltagy, Rasha/AAU-2252-2020; AlAmri, Dr
   Ohoud/AFC-7020-2022; Akabawy, Ahmed Mohammed Abd El-Mohsin
   Mahmoud/JPL-1102-2023; mahgoub, shahenda/D-6395-2019
OI Abdel Mohsen, Doaa/0000-0002-8312-4353; Akabawy, Ahmed Mohammed Abd
   El-Mohsin Mahmoud/0000-0002-5737-1166; mahgoub,
   shahenda/0000-0002-6095-1081; Al Amri, Ohoud/0000-0002-2820-3606; Amin,
   Hatem/0000-0003-3757-5927
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DI 10.1016/j.jff.2020.103996
PG 10
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA MH7XU
UT WOS:000546937800008
OA gold
DA 2025-06-11
ER

PT J
AU Farkhondeh, T
   Samarghandian, S
   Pourbagher-Shahri, AM
AF Farkhondeh, Tahereh
   Samarghandian, Saeed
   Pourbagher-Shahri, Ali Mohammad
TI Hypolipidemic effects of Rosmarinus officinalis L
SO JOURNAL OF CELLULAR PHYSIOLOGY
LA English
DT Review
DE carnosic acid; carnosol; dyslipidemia; rosemary; rosmarinic acid
ID LIMITS WEIGHT-GAIN; CARNOSIC ACID; METABOLIC SYNDROME; ROSEMARY
   EXTRACTS; DIABETES-MELLITUS; OBESITY; PROFILE; MICE; DIFFERENTIATION;
   STEATOSIS
AB Dyslipidemia is one of the major risk factors for cardiovascular diseases (CVDs). Current strategies are not effective in the management of dyslipidemia. Thus, there is a necessity to find new preventative and therapeutic approaches. In recent years, herbal medicine has drawn great attention regarding the prevention and management of dyslipidemia. Rosmarinus officinalis, commonly known as rosemary, is an evergreen shrub containing several polyphenols. The plant grows in the Mediterranean and South American regions. Rosemary and its main components have antioxidant, anti-inflammatory, and lipid-lowering properties. The present review has focused on in vivo and in vitro studies on the hypolipidemic effects of rosemary and its main constituents as well as their functional mechanisms. Studies have described lipid-scavenging activities of rosemary through its FLavonoid contents. Modulating inflammation and oxidative stress have been described as possible mechanisms by which rosemary ameliorates dyslipidemia. However, the exact mechanisms are not fully understood yet. Conducting experimental and clinical trial studies are recommended to confirm the safety and efficacy of rosemary in the prevention and management of dyslipidemia and other cardio-metabolic diseases.
C1 [Farkhondeh, Tahereh] Birjand Univ Med Sci, Cardiovasc Dis Res Ctr, Birjand, Iran.
   [Samarghandian, Saeed] Neyshabur Univ Med Sci, Dept Basic Med Sci, Neyshabur 9318614139, Iran.
   [Pourbagher-Shahri, Ali Mohammad] Birjand Univ Med Sci, Fac Med, Birjand, Iran.
C3 Birjand University of Medical Sciences; Birjand University of Medical
   Sciences
RP Samarghandian, S (corresponding author), Neyshabur Univ Med Sci, Dept Basic Med Sci, Neyshabur 9318614139, Iran.
EM samarghandians1@nums.ac.ir
RI Farkhondeh, Tahereh/Y-2083-2018; Pourbagher-Shahri, Ali
   Mohammad/Y-5021-2018
OI Pourbagher-Shahri, Ali Mohammad/0000-0003-4462-9890; farkhondeh,
   tahereh/0000-0002-9579-8339; , Saeed/0000-0001-5461-9579
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NR 73
TC 18
Z9 18
U1 2
U2 81
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0021-9541
EI 1097-4652
J9 J CELL PHYSIOL
JI J. Cell. Physiol.
PD SEP
PY 2019
VL 234
IS 9
BP 14680
EP 14688
DI 10.1002/jcp.28221
PG 9
WC Cell Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Physiology
GA IB3NM
UT WOS:000470174200025
PM 30693502
DA 2025-06-11
ER

PT J
AU Desmedt, S
   Desmedt, V
   De Vos, L
   Delanghe, JR
   Speeckaert, R
   Speeckaert, MM
AF Desmedt, Stephanie
   Desmedt, Valerie
   De Vos, Leen
   Delanghe, Joris R.
   Speeckaert, Reinhart
   Speeckaert, Marijn M.
TI Growth differentiation factor 15: A novel biomarker with high clinical
   potential
SO CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES
LA English
DT Review
DE Biomarker; growth differentiation factor 15; macrophage inhibitory
   cytokine-1; transforming growth factor-beta
ID MACROPHAGE INHIBITORY CYTOKINE-1; TGF-BETA SUPERFAMILY; ACUTE CORONARY
   SYNDROME; SENSITIVITY TROPONIN-T; HEART-FAILURE; MYOCARDIAL-INFARCTION;
   RISK STRATIFICATION; SOLUBLE ST2; ALL-CAUSE; CARDIOVASCULAR DYSFUNCTION
AB Initially considered as a macrophage inhibitor (macrophage inhibitory cytokine-1), growth differentiation factor 15 (GDF-15) has been identified as a pleiotropic protein that plays key roles in prenatal development, in inflammation, in the regulation of cellular responses to stress signals, and in tissue repair after acute injuries in adult life. Multiple studies have revealed that GDF-15, a distant member of the transforming growth factor beta (TGF-beta) family, acts as a critical hormone to regulate lipid and carbohydrate metabolism. Besides its role in the tumorigenesis and diagnosis of cancer, serum GDF-15 concentrations reflect a systemic response and are predictive of all-cause mortality. Based on the knowledge from animal studies of its involvement in multiple inflammatory processes, we will focus in this review on the current clinical data on GDF-15 as a biomarker for cardiovascular disease, kidney disease, liver disease, the metabolic syndrome, diabetes mellitus, and sepsis.
C1 [Desmedt, Stephanie; Desmedt, Valerie; De Vos, Leen; Speeckaert, Marijn M.] Ghent Univ Hosp, Dept Nephrol, Corneel Heymanslaan 10, B-9000 Ghent, Belgium.
   [Delanghe, Joris R.] Univ Ghent, Dept Diagnost Sci, Ghent, Belgium.
   [Speeckaert, Reinhart] Ghent Univ Hosp, Dept Dermatol, Ghent, Belgium.
   [Speeckaert, Marijn M.] Res Fdn Flanders, Brussels, Belgium.
C3 Ghent University; Ghent University Hospital; Ghent University; Ghent
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RP Speeckaert, MM (corresponding author), Ghent Univ Hosp, Dept Nephrol, Corneel Heymanslaan 10, B-9000 Ghent, Belgium.
EM Marijn.Speeckaert@ugent.be
RI Speeckaert, Marijn/HPB-8611-2023
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NR 169
TC 73
Z9 75
U1 1
U2 24
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1040-8363
EI 1549-781X
J9 CRIT REV CL LAB SCI
JI Crit. Rev. Clin. Lab. Sci.
PD JUL 4
PY 2019
VL 56
IS 5
BP 333
EP 350
DI 10.1080/10408363.2019.1615034
PG 18
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA IH7SF
UT WOS:000474703600004
PM 31076013
DA 2025-06-11
ER

PT J
AU Punapart, M
   Eltermaa, M
   Oflijan, J
   Sütt, S
   Must, A
   Koks, S
   Schalkwyk, LC
   Fernandes, C
   Vasar, E
   Soomets, U
   Terasmaa, A
AF Punapart, Marite
   Eltermaa, Mall
   Oflijan, Julia
   Suett, Silva
   Must, Anne
   Koks, Sulev
   Schalkwyk, Leonard C.
   Fernandes, Catherine
   Vasar, Eero
   Soomets, Ursel
   Terasmaa, Anton
TI Effect of Chronic Valproic Acid Treatment on Hepatic Gene Expression
   Profile in Wfs1 Knockout Mouse
SO PPAR RESEARCH
LA English
DT Article
ID ENDOPLASMIC-RETICULUM STRESS; WOLFRAM-SYNDROME GENE; BIPOLAR DISORDER;
   PPAR-DELTA; PSYCHIATRIC-DISORDERS; INCREASES EXPRESSION; THERAPEUTIC
   TARGET; METABOLIC SYNDROME; DIABETES-MELLITUS; CHROMOSOME 4P16
AB Valproic acid (VPA) is a widely used anticonvulsant and mood-stabilizing drug whose use is often associated with drug-induced weight gain. Treatment with VPA has been shown to upregulate Wfs1 expression in vitro. Aim of the present study was to compare the effect of chronic VPA treatment in wild type (WT) and Wfs1 knockout (KO) mice on hepatic gene expression profile. Wild type, Wfs1 heterozygous, and homozygous mice were treated with VPA for threemonths (300mg/kg i.p. daily) and gene expression profiles in liver were evaluated using Affymetrix Mouse GeneChip 1.0 ST array. We identified 42 genes affected by Wfs1 genotype, 10 genes regulated by VPA treatment, and 9 genes whose regulation by VPA was dependent on genotype. Among the genes that were regulated differentially by VPA depending on genotype was peroxisome proliferator-activated receptor delta (Ppard), whose expression was upregulated in response to VPA treatment in WT, but not in Wfs1 KO mice. Thus, regulation of Ppard by VPA is dependent on Wfs1 genotype.
C1 [Punapart, Marite; Eltermaa, Mall; Oflijan, Julia; Suett, Silva; Must, Anne; Koks, Sulev; Vasar, Eero; Terasmaa, Anton] Univ Tartu, Inst Biomed & Translat Med, Dept Physiol, EE-50411 Tartu, Estonia.
   [Punapart, Marite; Eltermaa, Mall; Oflijan, Julia; Suett, Silva; Must, Anne; Koks, Sulev; Vasar, Eero; Soomets, Ursel; Terasmaa, Anton] Ctr Excellence Translat Med, EE-50411 Tartu, Estonia.
   [Schalkwyk, Leonard C.; Fernandes, Catherine] Kings Coll London, Inst Psychiat Maudsley, SGDP, London SE5 8AF, England.
   [Soomets, Ursel] Univ Tartu, Inst Biomed & Translat Med, Dept Biochem, EE-50411 Tartu, Estonia.
C3 University of Tartu; University of London; King's College London;
   University of Tartu
RP Terasmaa, A (corresponding author), Univ Tartu, Inst Biomed & Translat Med, Dept Physiol, 19 Ravila St, EE-50411 Tartu, Estonia.
EM anton.terasmaa@ut.ee
RI Fernandes, Cathy/F-3422-2011; Vasar, Eero/H-4490-2015; Koks,
   Sulev/HSA-8160-2023; Must, Anne/I-3268-2016; Schalkwyk,
   Leonard/A-2150-2010; /H-3655-2015; Terasmaa, Anton/I-3312-2015; Soomets,
   Ursel/H-5919-2015
OI Schalkwyk, Leonard/0000-0001-7030-5756; /0000-0001-6087-6643; Terasmaa,
   Anton/0000-0002-5139-1764; Soomets, Ursel/0000-0002-3681-188X; Eltermaa,
   Mall/0000-0002-9651-4107; Fernandes, Cathy/0000-0001-7318-3352; Vasar,
   Eero/0000-0001-5226-345X
FU Estonian Science Foundation [GARFS 8414, GARBK 7856, SF0180148s08
   (TARFS0416)]; European Science Foundation [2949]; Centre of
   Translational Genomics of the University of Tartu [SP1GVARENG]; COST
   action [BM901]
FX This study was supported by Grants GARFS 8414, GARBK 7856, and
   SF0180148s08 (TARFS0416) from Estonian Science Foundation, by exchange
   Grant 2949 from European Science Foundation, by the Centre of
   Translational Genomics of the University of Tartu (SP1GVARENG) and by a
   COST action BM901.
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NR 56
TC 8
Z9 9
U1 0
U2 5
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1687-4757
EI 1687-4765
J9 PPAR RES
JI PPAR Res.
PY 2014
VL 2014
AR 349525
DI 10.1155/2014/349525
PG 11
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA AE8XU
UT WOS:000334287100001
PM 24799886
OA gold, Green Published, Green Accepted, Green Submitted
DA 2025-06-11
ER

PT J
AU Galigniana, NM
   Ruiz, MC
   Piwien-Pilipuk, G
AF Galigniana, Natalia M.
   Ruiz, Marina C.
   Piwien-Pilipuk, Graciela
TI FK506 binding protein 51: Its role in the adipose organ and beyond
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Review
DE adipogenesis; adipose tissue; FKBP51; obesity
ID ACTIVATED RECEPTOR-GAMMA; GLYCOGEN-SYNTHASE KINASE; DIET-INDUCED
   OBESITY; PPAR-GAMMA; INSULIN-RESISTANCE; GENE-EXPRESSION; C/EBP-BETA;
   ADIPOCYTE DIFFERENTIATION; MEDIATED PHOSPHORYLATION; INHIBIT
   ADIPOGENESIS
AB There is a great body of evidence that the adipose organ plays a central role in the control not only of energy balance, but importantly, in the maintenance of metabolic homeostasis. Interest in the study of different aspects of its physiology grew in the last decades due to the pandemic of obesity and the consequences of metabolic syndrome. It was not until recently that the first evidence for the role of the high molecular weight immunophilin FK506 binding protein (FKBP) 51 in the process of adipocyte differentiation have been described. Since then, many new facets have been discovered of this stress-responsive FKBP51 as a central node for precise coordination of many cell functions, as shown for nuclear steroid receptors, autophagy, signaling pathways as Akt, p38 MAPK, and GSK3, as well as for insulin signaling and the control of glucose homeostasis. Thus, the aim of this review is to integrate and discuss the recent advances in the understanding of the many roles of FKBP51 in the adipose organ.
C1 [Galigniana, Natalia M.; Ruiz, Marina C.; Piwien-Pilipuk, Graciela] Consejo Nacl Invest Cient & Tecn, Inst Biol & Med Expt IBYME, Lab Nucl Architecture, Buenos Aires, Argentina.
   [Galigniana, Natalia M.] Univ Oslo, Inst Basic Med Sci, Fac Med, Dept Mol Med, Oslo, Norway.
   [Piwien-Pilipuk, Graciela] Consejo Nacl Invest Cient & Tecn, Inst Biol & Med Expt IBYME, Lab Nucl Architecture, Vuelta Obligado 2490, RA-C1428ADN Buenos Aires, Argentina.
C3 Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET);
   Institute of Biology & Experimental Medicine; University of Oslo;
   Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET);
   Institute of Biology & Experimental Medicine
RP Piwien-Pilipuk, G (corresponding author), Consejo Nacl Invest Cient & Tecn, Inst Biol & Med Expt IBYME, Lab Nucl Architecture, Vuelta Obligado 2490, RA-C1428ADN Buenos Aires, Argentina.
EM gpiwien@conicet.gov.ar
OI Piwien-Pilipuk, Graciela/0000-0002-7289-5494; Galigniana, Natalia
   M./0000-0002-0712-719X
FU Agencia Nacional de Promocion Cientifica y Tecnologica; 
   [PICT2017-1692];  [PICT2018-3506]
FX ACKNOWLEDGMENTS This work was supported by grants from Agencia Nacional
   de Promocion Cientifica y Tecnologica to GPP (PICT2017-1692 and
   PICT2018-3506), Fundacion Rene Baron and Fundacion Williams.
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NR 159
TC 6
Z9 6
U1 0
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0730-2312
EI 1097-4644
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PD DEC
PY 2024
VL 125
IS 12
SI SI
DI 10.1002/jcb.30351
EA DEC 2022
PG 14
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA P7F7W
UT WOS:000895959100001
PM 36502528
DA 2025-06-11
ER

PT J
AU Topel, H
   Bagirsakçi, E
   Yilmaz, Y
   Günes, A
   Bagci, G
   Çömez, D
   Kahraman, E
   Korhan, P
   Atabey, N
AF Topel, Hande
   Bagirsakci, Ezgi
   Yilmaz, Yeliz
   Gunes, Aysim
   Bagci, Gulsun
   Comez, Dehan
   Kahraman, Erkan
   Korhan, Peyda
   Atabey, Nese
TI High glucose induced c-Met activation promotes aggressive phenotype and
   regulates expression of glucose metabolism genes in HCC cells
SO SCIENTIFIC REPORTS
LA English
DT Article
ID HEPATOCELLULAR-CARCINOMA; LIVER-CANCER; HYPERGLYCEMIA; PATHWAY; AXIS;
   INHIBITION; GLYCOLYSIS; APOPTOSIS; MOTILITY; PLATFORM
AB Hepatocellular carcinoma (HCC) is strongly associated with metabolic dysregulations/deregulations and hyperglycemia is a common metabolic disturbance in metabolic diseases. Hyperglycemia is defined to promote epithelial to mesenchymal transition (EMT) of cancer cells in various cancers but its molecular contribution to HCC progression and aggressiveness is relatively unclear. In this study, we analyzed the molecular mechanisms behind the hyperglycemia-induced EMT in HCC cell lines. Here, we report that high glucose promotes EMT through activating c-Met receptor tyrosine kinase via promoting its ligand-independent homodimerization. c-Met activation is critical for high glucose induced acquisition of mesenchymal phenotype, survival under high glucose stress and reprogramming of cellular metabolism by modulating glucose metabolism gene expression to promote aggressiveness in HCC cells. The crucial role of c-Met in high glucose induced EMT and aggressiveness may be the potential link between metabolic syndrome-related hepatocarcinogenesis and/or HCC progression. Considering c-Met inhibition in hyperglycemic patients would be an important complementary strategy for therapy that favors sensitization of HCC cells to therapeutics.
C1 [Topel, Hande; Bagirsakci, Ezgi; Yilmaz, Yeliz; Gunes, Aysim; Bagci, Gulsun; Comez, Dehan; Kahraman, Erkan; Korhan, Peyda; Atabey, Nese] Izmir Biomed & Genome Ctr IBG, TR-35340 Izmir, Turkey.
   [Topel, Hande; Yilmaz, Yeliz; Kahraman, Erkan] Dokuz Eylul Univ, Grad Sch Hlth Sci, Dept Med Biol & Genet, TR-35340 Izmir, Turkey.
   [Bagirsakci, Ezgi; Bagci, Gulsun; Comez, Dehan] Dokuz Eylul Univ, Izmir Int Biomed & Genome Inst, Dept Mol Biol & Genet, TR-35340 Izmir, Turkey.
C3 Izmir Biomedicine & Genome Center; Dokuz Eylul University; Dokuz Eylul
   University
RP Atabey, N (corresponding author), Izmir Biomed & Genome Ctr IBG, TR-35340 Izmir, Turkey.
EM nese.atabey@ibg.edu.tr
RI Kahraman, Erkan/AAE-6696-2019; Yilmaz, Yeliz/HJG-6563-2022; COMEZ,
   DEHAN/AAG-1632-2021; Korhan, Peyda/AAI-5995-2021; Topel,
   Hande/AAY-7627-2020; Atabey, Nese/A-1853-2018
OI COMEZ, DEHAN/0000-0001-6889-2429; Topel, Hande/0000-0001-5743-4019;
   Kahraman, Erkan/0000-0003-0051-416X; BAGCI, GULSUN/0000-0002-3901-6275;
   YILMAZ, YELIZ/0000-0003-4923-2788; Atabey, Nese/0000-0003-4966-2980
FU Scientific and Technological Research Council of Turkey (TUBITAK)
   [114S359]
FX We thank Prof. Dr. Mehmet Ozturk for providing HCC cells, Izmir
   Biomedicine and Genome Center for establishment of required technical
   and instrumental infrastructure for this study, Prof. Dr. Jan-Wilhelm
   Kornfeld and Dr. Matteo Oliverio for their support in Seahorse
   experiments and Dr. Yasemin oztemur Islakolu for her kind contribution
   to bioinformatic data analysis. This research was funded by "Scientific
   and Technological Research Council of Turkey (TUBITAK)" with the grant
   number of "114S359".
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NR 52
TC 14
Z9 16
U1 1
U2 12
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD MAY 31
PY 2021
VL 11
IS 1
AR 11376
DI 10.1038/s41598-021-89765-5
PG 15
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA SO8CQ
UT WOS:000659203100006
PM 34059694
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Prince, PD
   Fischerman, L
   Toblli, JE
   Fraga, CG
   Galleano, M
AF Denise Prince, Paula
   Fischerman, Laura
   Toblli, Jorge E.
   Fraga, Cesar G.
   Galleano, Monica
TI LPS-induced renal inflammation is prevented by (-)-epicatechin in rats
SO REDOX BIOLOGY
LA English
DT Article
DE Endotoxemia; Flavonoids; Renopathies; Toll-like receptors; Reactive
   oxygen species
ID NF-KAPPA-B; TOLL-LIKE RECEPTOR-4; NADPH OXIDASE; IN-VIVO; METABOLIC
   SYNDROME; ENDOTHELIAL-CELLS; 3T3-L1 ADIPOCYTES; OXIDATIVE STRESS;
   BLOOD-PRESSURE; NITRIC-OXIDE
AB This work investigated the capacity of (-)-epicatechin to prevent the renal damage induced by LPS administration in rats. Male Sprague Dawley rats were fed for 4 days a diet without or with supplementation with (-)-epicatechin (80 mg/kg BW/d), and subsequently i.p. injected with lipopolysaccharide (LPS). Six hours after injection, LPS-treated rats exhibited increased plasma creatinine and urea levels as indicators of impaired renal function. The renal cortex of the LPS-treated rats showed: i) increased expression of inflammatory molecules (TNF-alpha, iNOS and IL-6); ii) activation of several steps of NF-kappa B pathway; iii) overexpression of TLR4, and iv) higher superoxide anion production and lipid peroxidation index in association with increased levels of gp91(phox) and p47(phox) (NOX2) and NOX4. Pretreatment with dietary (-)-epicatechin prevented the adverse effects of LPS challenge essentially by inhibiting TLR4 upregulation and NOX activation and the consequent downstream events, e.g. NF-kappa B activation.
C1 [Denise Prince, Paula; Fischerman, Laura; Fraga, Cesar G.; Galleano, Monica] Univ Buenos Aires, Fac Farm & Bioquim, Dept Quim Analit & Fisicoquim, Catedra Fisicoquim, Buenos Aires, DF, Argentina.
   [Denise Prince, Paula; Fischerman, Laura; Fraga, Cesar G.; Galleano, Monica] Univ Buenos Aires, CONICET, Inst Bioquim & Med Mol IBIMOL, Buenos Aires, DF, Argentina.
   [Toblli, Jorge E.] Hosp Aleman, Lab Med Expt, Buenos Aires, DF, Argentina.
   [Fraga, Cesar G.] Univ Calif Davis, Dept Nutr, Davis, CA 95616 USA.
C3 University of Buenos Aires; University of Buenos Aires; Consejo Nacional
   de Investigaciones Cientificas y Tecnicas (CONICET); University of
   Buenos Aires; University of Buenos Aires Hospital; Hospital Aleman;
   University of California System; University of California Davis
RP Galleano, M (corresponding author), Univ Buenos Aires, Fac Farm & Bioquim, Dept Quim Analit & Fisicoquim, Catedra Fisicoquim, Buenos Aires, DF, Argentina.; Galleano, M (corresponding author), Univ Buenos Aires, CONICET, Inst Bioquim & Med Mol IBIMOL, Buenos Aires, DF, Argentina.
EM mgallean@ffyb.uba.ar
RI Prince, Paula/O-5318-2019; Fraga, Cesar/Q-8161-2019
OI Fraga, Cesar G./0000-0003-4168-9927; Prince, Paula
   Denise/0000-0002-7075-4014
FU Universidad de Buenos Aires [UBACyT 20020120100177, 20020130100760BA];
   Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET)
   [PIP0612]; Agencia Nacional de Promocion Cientifica y Tecnologica
   (ANPCyT) [PICT 2012-0765]
FX This work was supported by grants from the Universidad de Buenos Aires
   (UBACyT 20020120100177 and 20020130100760BA); Consejo Nacional de
   Investigaciones Cientificas y Tecnicas (CONICET) (PIP0612); and Agencia
   Nacional de Promocion Cientifica y Tecnologica (ANPCyT) (PICT
   2012-0765).
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   Steffen Y, 2007, BIOCHEM BIOPH RES CO, V359, P828, DOI 10.1016/j.bbrc.2007.05.200
   Vazquez-Prieto MA, 2012, ARCH BIOCHEM BIOPHYS, V527, P113, DOI 10.1016/j.abb.2012.02.019
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NR 46
TC 68
Z9 75
U1 0
U2 31
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 2213-2317
J9 REDOX BIOL
JI Redox Biol.
PD APR
PY 2017
VL 11
BP 342
EP 349
DI 10.1016/j.redox.2016.12.023
PG 8
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA EQ6RY
UT WOS:000398212000035
PM 28039839
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Rothermel, J
   Reinehr, T
AF Rothermel, Juliane
   Reinehr, Thomas
TI Metabolic alterations in paediatric GH deficiency
SO BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Article
DE growth hormone; lipids; glucose metabolism adipokines; fat mass intima;
   media thickness
ID GROWTH-HORMONE DEFICIENCY; INTIMA-MEDIA THICKNESS; CARDIOVASCULAR
   RISK-FACTORS; LIFE-STYLE INTERVENTION; IGF-BINDING PROTEIN-3; LONG-TERM
   MORTALITY; BODY-COMPOSITION; REPLACEMENT THERAPY; INSULIN-RESISTANCE;
   CHILDHOOD OBESITY
AB Growth hormone (GH) has a large number of metabolic effects, involving lipid and glucose homoeostasis, lean and fat mass. Growth hormone deficiency (GHD) is associated with a metabolic profile similar to the Metabolic Syndrome which is characterized by dyslipidemia, insulin resistance, haemostatic alterations, oxidative stress, and chronic inflammation. GH replacement treatment in GHD children improves these cardiovascular risk factors, while cessation of GH is associated with a deterioration of most of these risk factors. However, it is unclear whether the changes of these risk factors are associated with an increased risk of cardiovascular diseases especially after discontinuing GH treatment. GH treatment itself can lead to insulin resistance, which probably also influences the cardiovascular health status. Therefore, longitudinal studies with the primary outcome cardiovascular diseases are needed in GHD children. Furthermore, new approaches such as metabolomic studies might be helpful to understand the relationship between GHD, GH treatment, and cardiovascular diseases. (C) 2016 Elsevier Ltd. All rights reserved.
C1 [Rothermel, Juliane; Reinehr, Thomas] Univ Witten Herdecke, Vestische Hosp Children & Adolescents Datteln, Dept Paediat Endocrinol Diabet & Nutr Med, Dr F Steiner Str 5, D-45711 Datteln, Germany.
C3 Witten Herdecke University
RP Reinehr, T (corresponding author), Univ Witten Herdecke, Vestische Hosp Children & Adolescents Datteln, Dept Paediat Endocrinol Diabet & Nutr Med, Dr F Steiner Str 5, D-45711 Datteln, Germany.
EM T.Reinehr@kinderklinik-datteln.de
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NR 95
TC 35
Z9 35
U1 0
U2 16
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1521-690X
EI 1532-1908
J9 BEST PRACT RES CL EN
JI Best Pract. Res. Clin. Endoc. Metab.
PD DEC
PY 2016
VL 30
IS 6
BP 757
EP 770
DI 10.1016/j.beem.2016.11.004
PG 14
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA EG5LE
UT WOS:000391084500007
PM 27974189
DA 2025-06-11
ER

PT J
AU Markovic, VM
   Cupic, Z
   Macesic, S
   Stanojevic, A
   Vukojevic, V
   Kolar-Anic, L
AF Markovic, Vladimir M.
   Cupic, Zeljko
   Macesic, Stevan
   Stanojevic, Ana
   Vukojevic, Vladana
   Kolar-Anic, Ljiljana
TI Modelling cholesterol effects on the dynamics of the
   hypothalamic-pituitary-adrenal (HPA) axis
SO MATHEMATICAL MEDICINE AND BIOLOGY-A JOURNAL OF THE IMA
LA English
DT Article
DE hypothalamic-pituitary-adrenal (HPA) axis; cholesterol; circadian and
   ultradian rhythms; cortisol; dynamical diseases; stoichiometric network
   analysis
ID STOICHIOMETRIC NETWORK ANALYSIS; CORTICOTROPIN-RELEASING HORMONE;
   HIGH-FAT DIET; RHEUMATOID-ARTHRITIS; MATHEMATICAL-MODEL; METABOLIC
   SYNDROME; CIRCADIAN-RHYTHM; GENE-EXPRESSION; STRESS-RESPONSE; BASAL
   ACTIVITY
AB A mathematical model of the hypothalamic-pituitary-adrenal (HPA) axis with cholesterol as a dynamical variable was derived to investigate the effects of cholesterol, the primary precursor of all steroid hormones, on the ultradian and circadian HPA axis activity. To develop the model, the parameter space was systematically examined by stoichiometric network analysis to identify conditions for ultradian oscillations, determine conditions under which dynamic transitions, i.e. bifurcations occur and identify bifurcation types. The bifurcations were further characterized using numerical simulations. Model predictions agree well with empirical findings reported in the literature, indicating that cholesterol levels may critically affect the global dynamics of the HPA axis. The proposed model provides a base for better understanding of experimental observations, it may be used as a tool for designing experiments and offers useful insights into the characteristics of basic dynamic regulatory mechanisms that, when impaired, may lead to the development of some modern-lifestyle-associated diseases.
C1 [Markovic, Vladimir M.; Macesic, Stevan; Stanojevic, Ana; Kolar-Anic, Ljiljana] Univ Belgrade, Fac Phys Chem, Studentski Trg 12-16, Belgrade 11000, Serbia.
   [Cupic, Zeljko; Kolar-Anic, Ljiljana] Univ Belgrade, Inst Chem Technol & Met, Dept Catalysis & Chem Engn, Njegoseva 12, Belgrade 11000, Serbia.
   [Vukojevic, Vladana] Ctr Mol Med CMM, Karolinska Inst, Dept Clin Neurosci, L8 01, S-17176 Stockholm, Sweden.
C3 University of Belgrade; University of Belgrade; Karolinska Institutet
RP Markovic, VM (corresponding author), Univ Belgrade, Fac Phys Chem, Studentski Trg 12-16, Belgrade 11000, Serbia.; Vukojevic, V (corresponding author), Ctr Mol Med CMM, Karolinska Inst, Dept Clin Neurosci, L8 01, S-17176 Stockholm, Sweden.
EM vmarkovic@ffh.bg.ac.rs; vladana.vukojevic@ki.se
RI Macesic, Stevan/AAS-1179-2020; Čupić, Željko/ITU-7921-2023; Vukojevic,
   Vladana/AAY-3144-2021
OI Markovic, Vladimir M./0000-0003-3075-7226; Cupic,
   Zeljko/0000-0002-4939-6718; Stanojevic, Ana/0000-0002-8302-191X;
   Vukojevic, Vladana/0000-0003-0873-5653
FU Karolinska Institute Research Funds; Swedish Research Council; Knut and
   Alice Wallenberg Foundation; Rajko and Maj Dermanovic Fund; Ministry of
   Education, Science and Technological Development of the Republic of
   Serbia [172015, 45001]
FX Support from the Karolinska Institute Research Funds, the Swedish
   Research Council, the Knut and Alice Wallenberg Foundation, the Rajko
   and Maj Dermanovic Fund, and the Ministry of Education, Science and
   Technological Development of the Republic of Serbia, grants 172015 and
   45001, is gratefully acknowledged.
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NR 77
TC 19
Z9 19
U1 0
U2 8
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1477-8599
EI 1477-8602
J9 MATH MED BIOL
JI Math. Med. Biol.
PD MAR
PY 2016
VL 33
IS 1
BP 1
EP 28
DI 10.1093/imammb/dqu020
PG 28
WC Biology; Mathematical & Computational Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics; Mathematical & Computational
   Biology
GA DJ5FQ
UT WOS:000374232600001
PM 25332212
OA Green Published
DA 2025-06-11
ER

PT J
AU Yahagi, K
   Otsuka, F
   Sakakura, K
   Sanchez, OD
   Kutys, R
   Ladich, E
   Kolodgie, FD
   Virmani, R
   Joner, M
AF Yahagi, K.
   Otsuka, F.
   Sakakura, K.
   Sanchez, O. D.
   Kutys, R.
   Ladich, E.
   Kolodgie, F. D.
   Virmani, R.
   Joner, M.
TI Pathophysiology of superficial femoral artery in-stent restenosis
SO JOURNAL OF CARDIOVASCULAR SURGERY
LA English
DT Review
DE Coronary restenosis; Stents; Atherosclerosis
ID SMOOTH-MUSCLE-CELL; WALL SHEAR-STRESS; PERCUTANEOUS TRANSLUMINAL
   ANGIOPLASTY; PACLITAXEL-ELUTING STENTS; BALLOON ANGIOPLASTY; NITINOL
   STENT; FOLLOW-UP; ATHEROSCLEROTIC LESIONS; NEOINTIMAL HYPERPLASIA;
   ENDOVASCULAR TREATMENT
AB Peripheral artery disease (PAD) is an emerging problem especially with aging population and increase in the incidence of diabetes and metabolic syndrome. The disease is histologically characterized by the presence of moderate to severe calcification and fibrous plaques as compared to coronary and carotid atherosclerotic disease, which are richer in necrotic core. Endovascular therapy for the superficial femoral artery (SFA), at least in the United States, has been largely limited to balloon angioplasty and stenting and these are considered safe and relatively effective therapies. However, the patency rates remain low even at one year and restenosis is a growing and challenging problem. Recently the development of newer devices, i.e., drugeluting stent, and drug coated balloon are showing greater efficacy and are being adopted into daily practice. In this review, we will present the morphologic characteristics of the underlying SFA atherosclerotic disease and discuss in-stent restenosis and the mechanisms that may be involved in the induction of excessive smooth muscle cell proliferation and deposition of proteoglycans and collagen, that lead to restenosis.
C1 [Yahagi, K.; Otsuka, F.; Sakakura, K.; Sanchez, O. D.; Kutys, R.; Ladich, E.; Kolodgie, F. D.; Virmani, R.; Joner, M.] CVPath Inst Inc, Gaithersburg, MD 20878 USA.
C3 CVPath Institute
RP Joner, M (corresponding author), CVPath Inst Inc, 19 First Field Rd, Gaithersburg, MD 20878 USA.
EM mjoner@cvpath.org
RI Virmani, Renu/ADN-4400-2022; Sakakura, Kenichi/AAK-4564-2020
OI Sakakura, Kenichi/0000-0003-3566-0394
FU CVPath Institute, Gaithersburg, MD, USA
FX CVPath Institute, Gaithersburg, MD, USA provided full support for this
   work.
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NR 80
TC 51
Z9 57
U1 0
U2 13
PU EDIZIONI MINERVA MEDICA
PI TURIN
PA CORSO BRAMANTE 83-85 INT JOURNALS DEPT., 10126 TURIN, ITALY
SN 0021-9509
EI 1827-191X
J9 J CARDIOVASC SURG
JI J. Cardiovasc. Surg.
PD JUN
PY 2014
VL 55
IS 3
BP 307
EP 323
PG 17
WC Cardiac & Cardiovascular Systems; Surgery; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Surgery
GA AI4HF
UT WOS:000336825600002
PM 24755699
DA 2025-06-11
ER

PT J
AU Hawkins, UA
   Gomez-Sanchez, EP
   Gomez-Sanchez, CM
   Gomez-Sanchez, CE
AF Hawkins, Urseline A.
   Gomez-Sanchez, Elise P.
   Gomez-Sanchez, Clara M.
   Gomez-Sanchez, Celso E.
TI The Ubiquitous Mineralocorticoid Receptor: Clinical Implications
SO CURRENT HYPERTENSION REPORTS
LA English
DT Article
DE Hypertension; Blood pressure; Aldosterone; Mineralocorticoid receptor;
   (MR); Glucocorticoids; Thiazides; Thiazide diuretics; Congestive heart
   failure; CHF; Primary aldosteronism; Obesity; Diabetes mellitus;
   Diabetic nephropathy; Cardiac fibrosis; Metabolic syndrome; Sympathetic
   nerve activation; Hyperkalemia
ID LEFT-VENTRICULAR DYSFUNCTION; ACUTE MYOCARDIAL-INFARCTION; PRIMARY
   ALDOSTERONISM; HEART-FAILURE; PLASMA-ALDOSTERONE; INSULIN-RESISTANCE;
   BLOOD-PRESSURE; SALT APPETITE; SPIRONOLACTONE; HYPERTENSION
AB Mineralocorticoid receptors (MR) exist in many tissues, in which they mediate diverse functions crucial to normal physiology, including tissue repair and electrolyte and fluid homeostasis. However, inappropriate activation of MR within these tissues, and especially in the brain, causes hypertension and pathological vascular, cardiac, and renal remodeling. MR binds aldosterone, cortisol and corticosterone with equal affinity. In aldosterone-target cells, co-expression with the 11 beta-hydroxysteroid dehydrogenase 2 (HSD2) allows aldosterone specifically to activate MR. Aldosterone levels are excessive in primary aldosteronism, but in conditions with increased oxidative stress, like CHF, obesity and diabetes, MR may also be inappropriately activated by glucocorticoids. Unlike thiazide diuretics, MR antagonists are diuretics that do not cause insulin resistance. Addition of MR antagonists to standard treatment for hypertension and cardiac or renal disease decreases end-organ pathology and sympathetic nerve activation (SNA), and increases quality of life indices.
C1 [Hawkins, Urseline A.; Gomez-Sanchez, Elise P.; Gomez-Sanchez, Celso E.] GV Sonny Montgomery VA Med Ctr, Jackson, MS 39216 USA.
   [Hawkins, Urseline A.; Gomez-Sanchez, Elise P.; Gomez-Sanchez, Clara M.; Gomez-Sanchez, Celso E.] Univ Mississippi, Med Ctr, Div Endocrinol, Dept Med, Jackson, MS 39216 USA.
   [Gomez-Sanchez, Elise P.] Univ Mississippi, Med Ctr, Dept Pharmacol & Toxicol, Jackson, MS 39216 USA.
C3 University of Mississippi Medical Center; University of Mississippi;
   University of Mississippi Medical Center; University of Mississippi
RP Gomez-Sanchez, CE (corresponding author), GV Sonny Montgomery VA Med Ctr, 1500 E Woodrow Wilson Dr, Jackson, MS 39216 USA.
EM uhawkins@umc.edu; egomez-sanchez@umc.edu; cgomezsanchez@umc.edu;
   cgomez-sanchez@umc.edu
OI Gomez-Sanchez, Clara/0000-0003-2936-3246
FU NHLBI NIH HHS [R01 HL027255] Funding Source: Medline
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NR 98
TC 74
Z9 79
U1 0
U2 10
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1522-6417
EI 1534-3111
J9 CURR HYPERTENS REP
JI Curr. Hypertens. Rep.
PD DEC
PY 2012
VL 14
IS 6
BP 573
EP 580
DI 10.1007/s11906-012-0297-0
PG 8
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 032TL
UT WOS:000310741900013
PM 22843494
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Kennedy, DJ
   Kuchibhotla, S
   Westfall, KM
   Silverstein, RL
   Morton, RE
   Febbraio, M
AF Kennedy, David J.
   Kuchibhotla, Sai
   Westfall, Kristen M.
   Silverstein, Roy L.
   Morton, Richard E.
   Febbraio, Maria
TI A CD36-dependent pathway enhances macrophage and adipose tissue
   inflammation and impairs insulin signalling
SO CARDIOVASCULAR RESEARCH
LA English
DT Article
DE CD36; Obesity; Insulin resistance; Macrophages; Adipocytes
ID LOW-DENSITY-LIPOPROTEIN; FOAM CELL-FORMATION; METABOLIC SYNDROME; CD36
   DEFICIENCY; INNATE IMMUNITY; PPAR-GAMMA; RESISTANCE; OBESITY; RECEPTOR;
   MICE
AB Aims Obesity and hyperlipidaemia are associated with insulin resistance (IR); however, the mechanisms responsible remain incompletely understood. Pro-atherogenic hyperlipidaemic states are characterized by inflammation, oxidant stress, and pathophysiologic oxidized lipids, including ligands for the scavenger receptor CD36. Here we tested the hypothesis that the absence of CD36 protects mice from IR associated with diet-induced obesity and hyperlipidaemia.
   Methods and results Adipose tissue from CD36(-/-) mice demonstrated a less inflammatory phenotype and improved insulin signalling in vivo and at the level of the adipocyte and macrophage. The pathophysiologic ligand oxidized low-density lipoprotein (oxLDL) activated c-Jun N-terminal kinase (JNK) and disrupted insulin signalling in both adipocytes and macrophages in a CD36-dependent manner. Macrophages isolated from CD36(-/-) mice after high-fat diet feeding elicited less JNK activation and inhibition of insulin signalling in adipocytes after co-culture compared with wild-type macrophages.
   Conclusion These data suggest that a CD36-dependent inflammatory paracrine loop between adipocytes and macrophages facilitates chronic inflammation and contributes to IR common in obesity and dyslipidaemia.
C1 [Febbraio, Maria] Cleveland Clin, Lerner Res Inst, Dept Mol Cardiol, Cleveland, OH 44195 USA.
   [Kennedy, David J.; Kuchibhotla, Sai; Westfall, Kristen M.; Silverstein, Roy L.; Morton, Richard E.] Cleveland Clin, Lerner Res Inst, Dept Cell Biol, Cleveland, OH 44195 USA.
C3 Cleveland Clinic Foundation; Cleveland Clinic Foundation
RP Febbraio, M (corresponding author), Cleveland Clin, Lerner Res Inst, Dept Mol Cardiol, Cleveland, OH 44195 USA.
EM febbram@ccf.org
FU NIH [P01 HL087018, P01 HL46403, HL072942]; AHA Great Rivers Affiliate
   [0825685D]; Lerner Research Institute; Cleveland Clinic; American Heart
   Association (AHA) [0825685D] Funding Source: American Heart Association
   (AHA)
FX This work was supported by the NIH (P01 HL087018, P01 HL46403, HL072942
   to M.F. and R.L.S.); the AHA Great Rivers Affiliate (0825685D to
   D.J.K.); the Lerner Research Institute's David and Lindsay Morgenthaler
   Endowed Fellowship (to D.J.K.). Funding to pay the Open Access
   publication charge was provided by the Cleveland Clinic.
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NR 46
TC 148
Z9 166
U1 0
U2 25
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0008-6363
EI 1755-3245
J9 CARDIOVASC RES
JI Cardiovasc. Res.
PD FEB
PY 2011
VL 89
IS 3
BP 604
EP 613
DI 10.1093/cvr/cvq360
PG 10
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 712OT
UT WOS:000286676800018
PM 21088116
OA Green Submitted, Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Sakurai, T
   Nishioka, H
   Fujii, H
   Nakano, N
   Kizaki, T
   Radak, Z
   Izawa, T
   Haga, S
   Ohno, H
AF Sakurai, Takuya
   Nishioka, Hiroshi
   Fujii, Hajime
   Nakano, Norihiko
   Kizaki, Takako
   Radak, Zsolt
   Izawa, Tetsuya
   Haga, Shukoh
   Ohno, Hideki
TI Antioxidative effects of a new lychee fruit-derived polyphenol mixture,
   Oligonol, converted into a low-molecular form in adipocytes
SO BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
LA English
DT Article
DE adipocytes; Oligonol; antioxidative effects; adipokines; metabolic
   syndrome
ID NECROSIS-FACTOR-ALPHA; PLASMINOGEN-ACTIVATOR INHIBITOR-1; MONOCYTE
   CHEMOATTRACTANT PROTEIN-1; MANGANESE SUPEROXIDE-DISMUTASE; OXIDATIVE
   STRESS; ADIPOSE-TISSUE; EXPRESSION; ADIPONECTIN; OBESITY;
   DIFFERENTIATION
AB In this study we investigated the antioxidative effects of Oligonol (Amino Up Chemical Co., Ltd., Sapporo, Japan), a new polyphenol, in adipocytes. The levels of reactive oxygen species (ROS) and the expression of adipokine genes decreased in HW mouse white adipocytes upon treatment with Oligonol as compared to control cells. The transcriptional activity of nuclear factor-kappaB (NF-kappa B) and the activation of extracellular signal-regulated kinase (ERK) 1/2 were also down-regulated by Oligonol. In addition, when C57BL/6J mice were fed a high fat diet (HFD) for 5 weeks, the levels of epididymal white adipose tissue (WAT) mass and lipid peroxidation in WAT both increased, but Oligonol intake clearly inhibited such HFD-induced increases. Furthermore, dysregulated expression of genes for adipokines in WAT of mice fed solely a HFD was attenuated by Oligonol intake. These results suggest that Oligonol has antioxidative effects and that it attenuates HFD-induced dysregulated expression of genes for adipokines in adipocytes.
C1 [Sakurai, Takuya; Nakano, Norihiko; Kizaki, Takako; Ohno, Hideki] Kyorin Univ, Sch Med, Dept Mol Predict Med & Sport Sci, Mitaka, Tokyo 1818611, Japan.
   [Nishioka, Hiroshi; Fujii, Hajime] Amino Up Chem Co Ltd, Kiyoda Ku, Sapporo, Hokkaido 0040839, Japan.
   [Radak, Zsolt] Semmelweis Univ, Fac Phys Educ & Sport Sci, Inst Sport Sci, Budapest, Hungary.
   [Izawa, Tetsuya] Tokyo Metropolitan Univ, Grad Sch Human Hlth Sci, Hlth Promot Sci Grp, Hachioji, Tokyo 1920397, Japan.
   [Haga, Shukoh] Koriyama Womens Univ, Sch Hoem Econm, Dept Human Life Sci, Koriyama, Fukushima 9638503, Japan.
C3 Kyorin University; Semmelweis University; University of Physical
   Education; Tokyo Metropolitan University
RP Ohno, H (corresponding author), Kyorin Univ, Sch Med, Dept Mol Predict Med & Sport Sci, Mitaka, Tokyo 1818611, Japan.
EM ohnoh2o@kyorin-u.ac.jp
OI Izawa, Tetsuya/0000-0001-5197-9085; Radak, Zsolt/0000-0003-1297-6804
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NR 43
TC 62
Z9 68
U1 1
U2 14
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0916-8451
EI 1347-6947
J9 BIOSCI BIOTECH BIOCH
JI Biosci. Biotechnol. Biochem.
PD FEB
PY 2008
VL 72
IS 2
BP 463
EP 476
DI 10.1271/bbb.70567
PG 14
WC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
   Chemistry, Applied; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
   Chemistry; Food Science & Technology
GA 272WQ
UT WOS:000253892800025
PM 18256485
OA Bronze
DA 2025-06-11
ER

PT J
AU Yau, PL
   Kim, M
   Tirsi, A
   Convit, A
AF Yau, Po Lai
   Kim, Minsung
   Tirsi, Aziz
   Convit, Antonio
TI Retinal Vessel Alterations and Cerebral White Matter Microstructural
   Damage in Obese Adolescents With Metabolic Syndrome
SO JAMA PEDIATRICS
LA English
DT Article
ID ENDOTHELIAL DYSFUNCTION; INSULIN SENSITIVITY; ARTERIAL STIFFNESS;
   RISK-FACTORS; BRAIN; CHILDREN; ABNORMALITIES; ASSOCIATIONS; ALGORITHMS;
   DEPRESSION
AB IMPORTANCE Cerebral white matter (WM) damage has been reported in childhood obesity and in metabolic syndrome (MetS) but mechanisms remain unclear.
   OBJECTIVES To ascertain whether adolescents with MetS have retinal vessel alterations and if the anticipated reductions in retinal arteriolar diameter are associated with diminished cerebral WM microstructural integrity and to test a model for vascular etiology of the WM abnormalities.
   DESIGN, SETTING, AND PARTICIPANTS Cross-sectional study of the brain correlates of obesity and related metabolic disease in youths. This study was conducted at the Brain, Obesity, and Diabetes Laboratory, New York University School of Medicine, New York. Thirty-nine obese adolescents with MetS and 51 matched adolescents without MetS received comprehensive endocrine, neuropsychological, retinal vessel, and diffusion tensor imaging-based cerebral WM evaluations.
   MAIN OUTCOMES AND MEASURES Retinal arteriolar diameter, cerebral WM microstructural integrity, waist circumference, and insulin resistance.
   RESULTS Obese adolescents with MetS had significant reductions in retinal arteriolar diameter relative to adolescents without MetS (mean [SD] central retinal arteriolar equivalent, 182.35 [16.10] vs 198.62 [19.03] mu m, respectively; P < .001). The greater the number of MetS criteria present, the greater the reduction was in retinal arteriolar diameter (beta= -8.61; Delta r(2) = 0.335; Delta F-1,F-83 = 70.79; P < .001). We found that abdominal obesity (waist circumference) was the strongest MetS component related to reductions in retinal arteriolar diameter (r(p)[85] = -0.661; P < .001), and importantly, for the first time to our knowledge, we demonstrated that its effect was partially mediated by comorbid insulin resistance (indirect effect = -0.1355 [95% CI, -0.2471 to -0.0593]; Z = -2.56; P = .01). Consistent with our prior report of nondiabetic adolescents with MetS, we also uncovered cerebral WM microstructural damage. These subtle WM changes were associated with reductions in retinal arteriolar diameter, a proxy for cerebral microvascular health (3150 voxels or 3.15 cm(3); P < .001). Importantly, some of the WM regions showing lower microstructural integrity also demonstrated associations with retinal arteriolar diameter, suggesting that the observed WM pathology is likely vascular in nature.
   CONCLUSIONS AND RELEVANCE We document, for the first time to our knowledge, the associations between retinal vessel alterations and subclinical WM pathology among obese adolescents with MetS. This suggests that the subtle WM pathology in adolescents with MetS may have a vascular origin. Future work should include direct assessments of cerebral microvascular health.
C1 [Yau, Po Lai; Kim, Minsung; Tirsi, Aziz; Convit, Antonio] NYU, Sch Med, Dept Psychiat, New York, NY 10016 USA.
   [Convit, Antonio] NYU, Sch Med, Dept Med, New York, NY 10016 USA.
   [Convit, Antonio] NYU, Sch Med, Dept Radiol, New York, NY 10016 USA.
   [Convit, Antonio] Nathan S Kline Inst Psychiat Res, Orangeburg, NY USA.
C3 New York University; New York University; New York University; Nathan
   Kline Institute for Psychiatric Research
RP Convit, A (corresponding author), NYU, Sch Med, Brain Obes & Diabet Lab, 145 E 32nd St,Eighth Floor, New York, NY 10016 USA.
EM antonio.convit@med.nyu.edu
OI Yau, Po Lai/0000-0002-2901-2705; Convit, Antonio/0000-0003-2201-2689
FU National Institutes of Health [DK 083537]; National Center for Research
   Resources [1UL1RR029893]
FX This work was supported by grants DK 083537 from the National Institutes
   of Health and 1UL1RR029893 from the National Center for Research
   Resources.
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NR 40
TC 21
Z9 21
U1 0
U2 12
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 2168-6203
EI 2168-6211
J9 JAMA PEDIATR
JI JAMA Pediatr.
PD DEC
PY 2014
VL 168
IS 12
AR e142815
DI 10.1001/jamapediatrics.2014.2815
PG 10
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA AU9GO
UT WOS:000345900000002
PM 25436854
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Skonieski, C
   Fagundes, KR
   Silva, LD
   Segat, HJ
   Andrade, AJM
   Bolzan, RC
   Hirata, MH
   Ferreira, GM
   Benvegnu, DM
AF Skonieski, Calinca
   Fagundes, Karina Raquel
   Silva, Larissa da
   Segat, Hecson Jesser
   Andrade, Anderson Joel Martino
   Bolzan, Rodrigo Cordeiro
   Hirata, Mario Hiroyuki
   Ferreira, Glaucio Monteiro
   Benvegnu, Dalila Moter
TI Association of occupational exposure to pesticides with overweight in
   farmers in Southern Brazil
SO BIOMARKERS
LA English
DT Article
DE Agrochemicals; endocrine disruptors; obesity; associated comorbidities
ID PERSISTENT ORGANIC POLLUTANTS; DIET-INDUCED ADIPOSITY; ORGANOCHLORINE
   PESTICIDES; INSULIN-RESISTANCE; ENVIRONMENTAL OBESOGENS; CIRCULATING
   LEVELS; OXIDATIVE STRESS; NATIONAL-HEALTH; OBESITY; TISSUE
AB Introduction:Exposure to pesticides may be related to overweight and associated comorbidities. The aim of this work was to evaluate occupational exposure to pesticides, overweight and associated comorbidities among farmers in Southern Brazil. Methods:This cross-sectional study included a random sample of 257 farmers, living in the municipality of Mafra and Planalto, southern Brazil. Data on pesticide use and overweight prevalence from farmers were collected using an in-person interview questionnaire, followed by blood collection and biochemical analyses. Results:Pesticide exposure was positively correlated with body mass index, waist circumference, waist-to-hip ratio, triglycerides and glucose levels, presence of hypertension and metabolic syndrome. Besides that, the fact of being exposed to pesticides represents a decrease of no protein thiol groups. Furthermore, the main pesticides used by farmers have hepatic toxicity. Conclusion:These findings suggest that exposure to pesticides may be associated with overweight and associated comorbidities. Further studies are required to validate our findings and elucidate the specific mechanisms by which these pollutants contribute to the development of overweight.
C1 [Skonieski, Calinca; Fagundes, Karina Raquel; Silva, Larissa da; Benvegnu, Dalila Moter] Fed Univ Fronteira Sul UFFS, Campus Realeza, Realeza, PR, Brazil.
   [Segat, Hecson Jesser] Fed Univ Santa Maria UFSM, Dept Physiol & Pharmacol, Santa Maria, Brazil.
   [Andrade, Anderson Joel Martino] Univ Fed Parana, Dept Physiol, Curitiba, Brazil.
   [Bolzan, Rodrigo Cordeiro] Fed Univ Santa Maria UFSM, Dept Chem, Santa Maria, Brazil.
   [Hirata, Mario Hiroyuki; Ferreira, Glaucio Monteiro] Univ Sao Paulo, Sch Pharmaceut Sci, Dept Clin & Toxicol Anal, Sao Paulo, Brazil.
   [Benvegnu, Dalila Moter] State Univ West Parana Unioeste, Hlth Appl Sci Post Grad Program, Francisco Beltrao, Parana, Brazil.
C3 Universidade Federal de Santa Maria (UFSM); Universidade Federal do
   Parana; Universidade Federal de Santa Maria (UFSM); Universidade de Sao
   Paulo; Universidade Estadual do Oeste do Parana
RP Benvegnu, DM (corresponding author), Fed Univ Fronteira Sul UFFS, Campus Realeza, Realeza, PR, Brazil.
EM calincasko@gmail.com; dalilabenvegnu@yahoo.com.br
RI Benvegnú, Dalila/AAL-3958-2021; Hirata, Mario/C-9718-2013; Segat,
   Hecson/LWK-7668-2024; Monteiro Ferreira, Glaucio/X-6909-2018;
   Martino-Andrade, Anderson/E-1846-2014
OI Monteiro Ferreira, Glaucio/0000-0002-1952-9428; Benvegnu, Dalila
   Moter/0000-0002-3419-9674; Martino-Andrade,
   Anderson/0000-0001-5199-2810; Raquel Fagundes,
   Karina/0000-0003-2818-5601; Bolzan, Rodrigo/0000-0002-5176-1438;
   Skonieski, Calinca/0000-0003-4204-3861
FU CNPq, Brazil [447120/2014-0]; FAPESP, Brazil [2016/12899-6,
   2019/06172-4, 2019/24112-9]; Araucaria Foundation, Brazil
   [496/GR/UFFS/2018]
FX This study was partially supported by: CNPq (Grant # 447120/2014-0) and
   FAPESP (Grant # 2016/12899-6, 2019/06172-4 and 2019/24112-9), Brazil.
   MHH is recipients of fellowships from CNPq and FAPESP, Brazil. GMF is a
   recipient of a fellowship from FAPESP, Brazil. CS received of a
   fellowship from Araucaria Foundation, Brazil (496/GR/UFFS/2018).
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NR 72
TC 1
Z9 2
U1 1
U2 13
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1354-750X
EI 1366-5804
J9 BIOMARKERS
JI Biomarkers
PD DEC 3
PY 2023
VL 28
IS 7
BP 608
EP 616
DI 10.1080/1354750X.2023.2268859
EA OCT 2023
PG 9
WC Biotechnology & Applied Microbiology; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Toxicology
GA AG1N3
UT WOS:001087371300001
PM 37815377
DA 2025-06-11
ER

PT J
AU Bakis, H
   Lasseur, C
   Pfirmann, P
   Combe, C
   Chauveau, P
AF Bakis, Hugo
   Lasseur, Catherine
   Pfirmann, Pierre
   Combe, Christian
   Chauveau, Philippe
TI Vegetarian, Mediterranean diet and chronic kidney diseases
SO CAHIERS DE NUTRITION ET DE DIETETIQUE
LA English
DT Article
DE Chronic kidney disease; Plant-based diet; Mediterranean diet; Vegetarian
   diet
ID ALL-CAUSE MORTALITY; PLANT-BASED DIETS; METABOLIC-ACIDOSIS;
   NUTRITIONAL-STATUS; OXIDATIVE STRESS; PROTEIN-INTAKE; HEMODIALYSIS;
   RISK; PATTERNS; FIBER
AB Increase the intake of plants, vegetables, fruits and decrease in animal intake characterize plant-based diet (PBD). Vegetarian diet (VG) and Mediterranean diet (MD) in gene-ral population are associated with lower incident chronic kidney disease (CKD). It may be in relation with a reduction in glomerular hyperfiltration and of cardiovascular comorbidities (dia-betes mellitus, arterial hypertension, metabolic syndrome). Considering CKD patients, there are numerous evidence for an association between these diet patterns and slower CKD progression. In addition, VG and MD are associated with better management of CKD complications: bet-ter control of metabolic acidosis and calcium and phosphate homeostasis, reduction in uremic toxins and chronic inflammation. PBD is associated with a diminution of morbidity and mor-tality amongst CKD population. Hyperkaliemia and protein energy wasting conditions are not limiting introduction of these dietary patterns. Furthermore, PBD are in accordance with CKD nutritional recommendations. For these reasons, VG and MD should occupy a prominent place in CKD medical nutrition therapy.(c) 2022 Societe francaise de nutrition. Published by Elsevier Masson SAS. All rights reserved.
C1 [Bakis, Hugo; Pfirmann, Pierre; Combe, Christian] CHU Bordeaux, Serv nephrol transplantat dialyse & aphereses, Pl Amelie Raba Leon, F-33000 Bordeaux, France.
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C3 Universite de Bordeaux; CHU Bordeaux; Institut National de la Sante et
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RP Bakis, H (corresponding author), CHU Bordeaux, Serv nephrol transplantat dialyse & aphereses, Pl Amelie Raba Leon, F-33000 Bordeaux, France.
EM hugo.bakis@chu-bordeaux.fr
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NR 75
TC 1
Z9 1
U1 5
U2 18
PU MASSON EDITEUR
PI MOULINEAUX CEDEX 9
PA 21 STREET CAMILLE DESMOULINS, ISSY, 92789 MOULINEAUX CEDEX 9, FRANCE
SN 0007-9960
J9 CAH NUTR DIET
JI Cah. Nutr. Diet.
PD OCT
PY 2022
VL 57
IS 5
BP 315
EP 324
DI 10.1016/j.cnd.2022.02.005
EA OCT 2022
PG 10
WC Nutrition & Dietetics
WE Emerging Sources Citation Index (ESCI)
SC Nutrition & Dietetics
GA 6S6GP
UT WOS:000893083500007
OA Bronze
DA 2025-06-11
ER

PT J
AU Xia, N
   Daiber, A
   Förstermann, U
   Li, HG
AF Xia, Ning
   Daiber, Andreas
   Foerstermann, Ulrich
   Li, Huige
TI Antioxidant effects of resveratrol in the cardiovascular system
SO BRITISH JOURNAL OF PHARMACOLOGY
LA English
DT Review
ID ENDOTHELIAL NITRIC-OXIDE; CORONARY-ARTERY-DISEASE; FATTY LIVER-DISEASE;
   VASCULAR OXIDATIVE STRESS; SMALL-MOLECULE ACTIVATORS; TYPE-2
   DIABETES-MELLITUS; BLOOD MONONUCLEAR-CELLS; CLINICAL-TRIAL;
   SUPEROXIDE-DISMUTASE; METABOLIC SYNDROME
AB The antioxidant effects of resveratrol (3,5,4'-trihydroxy-trans-stilbene) contribute substantially to the health benefits of this compound. Resveratrol has been shown to be a scavenger of a number of free radicals. However, the direct scavenging activities of resveratrol are relatively poor. The antioxidant properties of resveratrol in vivo are more likely to be attributable to its effect as a gene regulator. Resveratrol inhibits NADPH oxidase-mediated production of ROS by down-regulating the expression and activity of the oxidase. This polyphenolic compound reduces mitochondrial superoxide generation by stimulating mitochondria biogenesis. Resveratrol prevents superoxide production from uncoupled endothelial nitric oxide synthase by up-regulating the tetrahydrobiopterin-synthesizing enzyme GTP cyclohydrolase I. In addition, resveratrol increases the expression of various antioxidant enzymes. Some of the gene-regulating effects of resveratrol are mediated by the histone/protein deacetylase sirtuin 1 or by the nuclear factor-E2-related factor-2. In this review article, we have also summarized the cardiovascular effects of resveratrol observed in clinical trials.
C1 [Xia, Ning; Foerstermann, Ulrich; Li, Huige] Johannes Gutenberg Univ Mainz, Dept Pharmacol, Med Ctr, Obere Zahlbacher Str 67, D-55131 Mainz, Germany.
   [Daiber, Andreas] Johannes Gutenberg Univ Mainz, Med Ctr, Med Dept Cardiol & Angiol 2, Mainz, Germany.
C3 Johannes Gutenberg University of Mainz; Johannes Gutenberg University of
   Mainz
RP Li, HG (corresponding author), Johannes Gutenberg Univ Mainz, Dept Pharmacol, Med Ctr, Obere Zahlbacher Str 67, D-55131 Mainz, Germany.
EM huigeli@uni-mainz.de
RI Daiber, Andreas/HJY-5274-2023; Li, Huige/M-2662-2013; Xia, Dr.,
   Ning/P-3535-2015
OI Li, Huige/0000-0003-3458-7391; Xia, Dr., Ning/0000-0002-5553-1752
FU Collaborative Research Center [SFB 553]; DFG (Deutsche
   Forschungsgemeinschaft), Bonn, Germany [LI-1042/1-1, LI-1042/3-1];
   European Cooperation in Science and Research (COST Action)
   [BM1203/EU-ROS]
FX Original work from our own laboratory contributing to this review was
   supported by the Collaborative Research Center SFB 553 and by grants
   LI-1042/1-1 and LI-1042/3-1 from the DFG (Deutsche
   Forschungsgemeinschaft), Bonn, Germany. The present work was supported
   by the European Cooperation in Science and Research (COST Action
   BM1203/EU-ROS).
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NR 122
TC 430
Z9 464
U1 12
U2 159
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0007-1188
EI 1476-5381
J9 BRIT J PHARMACOL
JI Br. J. Pharmacol.
PD JUN
PY 2017
VL 174
IS 12
SI SI
BP 1633
EP 1646
DI 10.1111/bph.13492
PG 14
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA EV9YH
UT WOS:000402143300008
PM 27058985
OA Bronze, Green Published
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Zeman, M
   Vecka, M
   Perlík, F
   Stanková, B
   Hromádka, R
   Tvrzická, E
   Sirc, J
   Hrib, J
   Zák, A
AF Zeman, Miroslav
   Vecka, Marek
   Perlik, Frantisek
   Stankova, Barbora
   Hromadka, Robert
   Tvrzicka, Eva
   Sirc, Jakub
   Hrib, Jakub
   Zak, Ales
TI Pleiotropic effects of niacin: Current possibilities for its clinical
   use
SO ACTA PHARMACEUTICA
LA English
DT Review
DE niacin; pleiotropic effects; HCA2 receptor; dyslipidemia; cardiovascular
   mortality/morbidity
ID EXTENDED-RELEASE NIACIN; CORONARY-HEART-DISEASE; PLASMA ADIPONECTIN
   LEVELS; NICOTINIC-ACID; OXIDATIVE STRESS; CARDIOVASCULAR-DISEASE;
   INSULIN-RESISTANCE; MYOCARDIAL-INFARCTION; VASCULAR INFLAMMATION;
   METABOLIC SYNDROME
AB Niacin was the first hypolipidemic drug to significantly reduce both major cardiovascular events and mortality in patients with cardiovascular disease. Niacin favorably influences all lipoprotein classes, including lipoprotein[a],and belongs to the most potent hypolipidemic drugs for increasing HDL-C. Moreover, niacin causes favorable changes to the qualitative composition of lipoprotein HDL. In addition to its pronounced hypolipidemic action, niacin exerts many other, non-hypolipidemic effects (e.g., antioxidative, anti-inflammatory, antithrombotic), which favorably influence the development and progression of atherosclerosis. These effects are dependent on activation of the specific receptor HCA2. Recent results published by the two large clinical studies, AIM-HIGH and HPS2-THRIVE, have led to the impugnation of niacin's role in future clinical practice. However, due to several methodological flaws in the AIM-HIGH and HPS2-THRIVE studies, the pleiotropic effects of niacin now deserve thorough evaluation. This review summarizes the present and possible future use of niacin in clinical practice in light of its newly recognized pleiotropic effects.
C1 [Zeman, Miroslav; Vecka, Marek; Stankova, Barbora; Tvrzicka, Eva; Zak, Ales] Charles Univ Prague, Fac Med 1, Dept Med 4, Prague, Czech Republic.
   [Perlik, Frantisek] Charles Univ Prague, Fac Med 1, Inst Pharmacol, Prague, Czech Republic.
   [Hromadka, Robert] C2P Sro, Ctr Res & Dev, Chlumecln Cidlinou, Czech Republic.
   [Sirc, Jakub; Hrib, Jakub] Acad Sci Czech Republ Prague, Inst Macromol Chem, Prague, Czech Republic.
C3 Charles University Prague; Charles University Prague; Czech Academy of
   Sciences; Institute of Macromolecular Chemistry of the Czech Academy of
   Sciences
RP Zeman, M (corresponding author), Charles Univ Prague, Fac Med 1, Dept Med 4, Prague, Czech Republic.
EM mirozem@centrum.cz
RI Hrib, Jakub/H-8160-2014; Sirc, Jakub/I-1015-2014; Vecka,
   Marek/A-3560-2008; Tvrzicka, Eva/Q-6300-2016; Zeman,
   Miroslav/J-5281-2016; Zak, Ales/G-8318-2016; Stankova,
   Barbora/L-7933-2016; Perlik, Frantisek/K-3555-2017
OI Vecka, Marek/0000-0002-3269-1817; Tvrzicka, Eva/0000-0003-0794-8454;
   Zeman, Miroslav/0000-0001-5338-603X; Sirc, Jakub/0000-0003-4373-8470;
   Zak, Ales/0000-0002-1698-6068; Stankova, Barbora/0000-0002-6184-4878;
   Perlik, Frantisek/0000-0002-6089-1883
FU  [MPO TIP FR-TI4/638]
FX The study was supported by Research grant MPO TIP FR-TI4/638.
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NR 129
TC 25
Z9 25
U1 0
U2 23
PU SCIENDO
PI WARSAW
PA BOGUMILA ZUGA 32A, WARSAW, MAZOVIA, POLAND
SN 1330-0075
EI 1846-9558
J9 ACTA PHARMACEUT
JI Acta Pharm.
PD DEC
PY 2016
VL 66
IS 4
BP 449
EP 469
DI 10.1515/acph-2016-0043
PG 21
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA EA8CS
UT WOS:000386863500001
PM 27749252
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Kolovou, G
   Ooi, TC
AF Kolovou, Genovefa
   Ooi, Teik Chye
TI Postprandial lipaemia and vascular disease
SO CURRENT OPINION IN CARDIOLOGY
LA English
DT Review
DE coronary heart disease; hypertriglyceridaemia; peripheral artery
   disease; postprandial lipaemia
ID TRIGLYCERIDE-RICH LIPOPROTEINS; ENDOTHELIAL PROGENITOR CELLS;
   REMNANT-LIKE LIPOPROTEINS; METABOLIC SYNDROME; NONFASTING TRIGLYCERIDES;
   CLINICAL-RELEVANCE; HEART-DISEASE; DIABETES-MELLITUS; OXIDATIVE STRESS;
   LDL SUBCLASSES
AB Purpose of reviewIn this review we discuss the postprandial pathophysiological mechanisms that promote vascular disease, the evidence for a role of postprandial lipaemia (PPL) in vascular disease and the effect of modifiable and nonmodifiable factors in PPL.Recent findingsPPL refers to the dynamic changes in serum lipids and lipoproteins (mainly in serum triglycerides) that occur after a fat load or a meal. Recent data indicate that postprandial or nonfasting triglyceride levels are better predictors of cardiovascular risk, suggesting that efficiency of postprandial handling of triglyceride-rich lipoproteins plays a role in the causation of vascular disease.SummaryThe recent finding that postprandial serum triglyceride levels are even better than fasting serum triglyceride levels as predictors of vascular disease indicate that it is better to measure an index of triglyceride-rich lipoproteins (in most cases serum triglyceride levels) in the postprandial period than in the postabsorptive fasting state. Moreover, by the time the postabsorptive state is reached, some of these proatherogenic triglyceride-rich lipoprotein changes may be missed in the measurement.
C1 [Kolovou, Genovefa] Onassis Cardiac Surg Ctr, Dept Cardiol, Athens 17674, Greece.
   [Ooi, Teik Chye] Univ Ottawa, Ottawa Hosp, Res Inst, Chron Dis Program, Ottawa, ON, Canada.
   [Ooi, Teik Chye] Univ Ottawa, Ottawa Hosp, Dept Med, Ottawa, ON, Canada.
C3 Onassis Cardiac Surgery Center; University of Ottawa; Ottawa Hospital
   Research Institute; University of Ottawa; Ottawa Hospital Research
   Institute
RP Kolovou, G (corresponding author), Onassis Cardiac Surg Ctr, 356 Sygrou Ave, Athens 17674, Greece.
EM genovefa@kolovou.com
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NR 86
TC 28
Z9 29
U1 2
U2 15
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0268-4705
EI 1531-7080
J9 CURR OPIN CARDIOL
JI Curr. Opin. Cardiol.
PD JUL
PY 2013
VL 28
IS 4
BP 446
EP 451
DI 10.1097/HCO.0b013e3283606971
PG 6
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 247DM
UT WOS:000326594900010
PM 23591556
DA 2025-06-11
ER

EF﻿FN Clarivate Analytics Web of Science
VR 1.0
PT J
AU Huerta-alvarez, A
   Arellano, M
   Chávez-Méndez, CA
   Carpinteyro-Espin, P
   Palacios-Reyes, C
   Perez-Escobar, J
AF Huerta-alvarez, Aline
   Arellano, Mariana
   Chavez-Mendez, Clyo Anahi
   Carpinteyro-Espin, Paulina
   Palacios-Reyes, Carmen
   Perez-Escobar, Juanita
TI Milpa Diet for MASLD in Mesoamerican Populations: Feasibility,
   Advantages, and Future Perspectives
SO LIFE-BASEL
LA English
DT Review
DE milpa diet; MASLD; antioxidants; proteins; fiber
ID FATTY LIVER-DISEASE; INSULIN-RESISTANCE; OXIDATIVE STRESS; HEPATIC
   STEATOSIS; CONSUMPTION; CINNAMON; SERUM; PROTEIN; ADULTS; RISK
AB Metabolic dysfunction-associated steatotic liver disease (MASLD) is the leading cause of chronic liver disease, linked closely to metabolic syndrome and rising obesity rates. Affecting up to 37% of the global adult population, MASLD prevalence is exceptionally high among individuals of Hispanic descent, with genetic factors such as the PNPLA3 gene mutation playing a significant role. The subject of this review is the traditional Mesoamerican "milpa" diet, which includes unprocessed local crops like maize, beans, pumpkins, chili, and tomatoes and may represent a strategy to combat MASLD. Current treatment recommendations emphasize weight loss; a reduced intake of saturated fats, processed meats, and added sugars; and increased physical activity. The milpa diet, rich in protein, fiber, vitamins, and bioactive compounds, aligns with these recommendations and could potentially mitigate MASLD by preventing liver fat accumulation and fibrosis. This narrative review focuses on available preclinical and clinical studies adopting the milpa diet as a culturally relevant, nutritious, and sustainable dietary approach in preventing and treating MASLD. More clinical studies are needed to develop precise nutritional quantitative recommendations and guidelines.
C1 [Huerta-alvarez, Aline] Hosp Juarez Mexico, Dept Nutr, Mexico City 07760, Mexico.
   [Arellano, Mariana] Natl Inst Publ Hlth, Ctr Res Nutr & Hlth, Cuernavaca 62100, Mexico.
   [Chavez-Mendez, Clyo Anahi] Hosp Angeles Mocel, Private Nutr Practice, Mexico City 11850, Mexico.
   [Carpinteyro-Espin, Paulina; Perez-Escobar, Juanita] Hosp Juarez Mexico, Dept Transplantat, Mexico City 07760, Mexico.
   [Palacios-Reyes, Carmen] Univ Guanajuato, Dept Ciencias Med, Div Ciencias Salud, Leon De Los Aldama 37320, Mexico.
C3 Instituto Nacional de Salud Publica; Universidad de Guanajuato
RP Perez-Escobar, J (corresponding author), Hosp Juarez Mexico, Dept Transplantat, Mexico City 07760, Mexico.
EM nutriologaaline@gmail.com; mc.arellano99@gmail.com;
   nc.clyochavez@gmail.com; paucarpi@gmail.com; cyapalacios@gmail.com;
   dra.jsperez@gmail.com
RI Palacios, Carmen/JCE-8677-2023
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NR 104
TC 0
Z9 0
U1 0
U2 0
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2075-1729
J9 LIFE-BASEL
JI Life-Basel
PD MAY 19
PY 2025
VL 15
IS 5
AR 812
DI 10.3390/life15050812
PG 17
WC Biology; Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics; Microbiology
GA 3CC3B
UT WOS:001496788500001
PM 40430238
DA 2025-06-11
ER

PT J
AU Maghool, F
   Emami, MH
   Alipour, R
   Mohammadzadeh, S
   Dehkordi, SAE
   Sereshki, N
   Fahim, A
   Tayarani-Najaran, Z
   Sheikh, A
   Kesharwani, P
   Sahebkar, A
AF Maghool, Fatemeh
   Emami, Mohammad Hassan
   Alipour, Razieh
   Mohammadzadeh, Samane
   Dehkordi, Sayed Ali Ehsan
   Sereshki, Nasrin
   Fahim, Alireza
   Tayarani-Najaran, Zahra
   Sheikh, Afsana
   Kesharwani, Prashant
   Sahebkar, Amirhossein
TI Rescue effect of curcumin against copper toxicity
SO JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
LA English
DT Article
DE Turmeric; Wounds; Curcuminoids; Heavy metals; Antioxidant;
   Anti-inflammatory; Curcumin; Hepatic diseases; Neurodegenerative
   diseases; Cardiovascular disease; Copper-curcumin interaction
ID INDUCED OXIDATIVE STRESS; WILSONS-DISEASE; DNA-DAMAGE; CELLS; RATS;
   NEUROTOXICITY; CYTOTOXICITY; INTOXICATION; INVOLVEMENT; INDUCTION
AB Turmeric has long been used not only as an indispensable part of Asian cuisine but as a medicinal herb for dressing wounds, bites, burns, treating eye infections and acne. Curcuminoids are the active substances and their synthetic derivatives (i.e. diacetylcurcumin (DAC) and metal-curcumin complexes) possess an incredibly wide range of medicinal properties that encompass chelation capacity for multiple heavy metals, antioxidant activity, anti-inflammatory properties, cytotoxicity against cancerous cells, antiviral and antibacterial effects, antihypertensive and insulin sensitizing role, and regulatory role on apoptosis. The aforementioned properties have put curcumin on spotlight as a potential treatment for ailments such as, hepatic diseases, neurodegenerative diseases, metabolic syndrome, dyslipidemia, cardiovascular disease, auto-immune diseases, malignancies and conditions associated with metal overload. Copper is essential for major biological functions, however, an excess causes chronic ailments including neurodegenerative disorders. The fascinating approach of curcumin could alleviate such effect by forming a complex. Thus, this review aims to present available data on the effect of coppercurcumin interaction in various in vitro, ex-vivo in vivo, and clinical studies.
C1 [Maghool, Fatemeh; Emami, Mohammad Hassan; Mohammadzadeh, Samane; Sereshki, Nasrin; Fahim, Alireza] Isfahan Univ Med Sci, Poursina Hakim Digest Dis Res Ctr, Esfahan, Iran.
   [Alipour, Razieh] Isfahan Univ Med Sci, Med Sch, Immunol Dept, Esfahan, Iran.
   [Dehkordi, Sayed Ali Ehsan] Univ Debrecen, Med Sch Hungary, Egyet ter 1, Debrecen, Hungary.
   [Tayarani-Najaran, Zahra] Mashhad Univ Med Sci, Med Toxicol Res Ctr, Mashhad, Iran.
   [Tayarani-Najaran, Zahra] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Targeted Drug Delivery Res Ctr, Mashhad, Iran.
   [Sheikh, Afsana; Kesharwani, Prashant] Jamia Hamdard, Sch Pharmaceut Educ & Res, Dept Pharmaceut, New Delhi 110062, India.
   [Kesharwani, Prashant] Saveetha Inst Med & Tech Sci, Saveetha Dent Coll, Ctr Transdisciplinary Res, Dept Pharmacol, Chennai 602105, India.
   [Kesharwani, Prashant] Chandigarh Univ, Univ Inst Pharm Sci, Mohali, Punjab, India.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Biotechnol Res Ctr, Mashhad, Iran.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Appl Biomed Res Ctr, Mashhad, Iran.
   [Sahebkar, Amirhossein] Univ Western Australia, Sch Med, Perth, Australia.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Sch Pharm, Dept Biotechnol, Mashhad, Iran.
C3 Isfahan University of Medical Sciences; Isfahan University of Medical
   Sciences; University of Debrecen; Mashhad University of Medical
   Sciences; Mashhad University of Medical Sciences; Jamia Hamdard
   University; Saveetha Institute of Medical & Technical Science; Saveetha
   Dental College & Hospital; Chandigarh University; Mashhad University of
   Medical Sciences; Mashhad University of Medical Sciences; University of
   Western Australia; Mashhad University of Medical Sciences
RP Kesharwani, P (corresponding author), Jamia Hamdard, Sch Pharmaceut Educ & Res, Dept Pharmaceut, New Delhi 110062, India.; Sahebkar, A (corresponding author), Mashhad Univ Med Sci, Pharmaceut Technol Inst, Biotechnol Res Ctr, Mashhad, Iran.
EM prashantdops@gmail.com; amir_saheb2000@yahoo.com
RI Maghool, Fatemeh/ABI-7612-2020; emami, Mohammad/HGU-9687-2022;
   Mohammadzadeh, Samane/AAV-5570-2020; Sereshki, Nasrin/AAF-6882-2019;
   Tayarani-Najaran, Zahra/I-1999-2014; Sahebkar, Amirhossein/B-5124-2018;
   Sheikh, Afsana/LCE-4217-2024
OI Emami, Mohammad Hassan/0000-0002-0318-0081
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NR 106
TC 11
Z9 11
U1 2
U2 18
PU ELSEVIER GMBH
PI MUNICH
PA HACKERBRUCKE 6, 80335 MUNICH, GERMANY
SN 0946-672X
EI 1878-3252
J9 J TRACE ELEM MED BIO
JI J. Trace Elem. Med. Biol.
PD JUL
PY 2023
VL 78
AR 127153
DI 10.1016/j.jtemb.2023.127153
EA MAR 2023
PG 11
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA D8HI7
UT WOS:000971078900001
PM 36989586
DA 2025-06-11
ER

PT J
AU Musumeci, ML
   Nasca, MR
   Boscaglia, S
   Micali, G
AF Musumeci, Maria L.
   Nasca, Maria R.
   Boscaglia, Simona
   Micali, Giuseppe
TI The role of lifestyle and nutrition in psoriasis: Current status of
   knowledge and interventions
SO DERMATOLOGIC THERAPY
LA English
DT Review
DE diet; food; lifestyle; nutrients; nutrition; psoriasis
ID METABOLIC SYNDROME; CELIAC-DISEASE; WESTERN DIET; RISK; ASSOCIATION;
   CONSUMPTION; PATHOGENESIS; METAANALYSIS; COFFEE; GAMMA
AB Extrinsic environmental factors, including patient lifestyle (alcohol intake, smoking, stress, sleep disturbances, and sedentary habit), diet and single nutrients intake may affect psoriasis clinical presentation, severity, and course. All English language articles dealing with psoriasis and lifestyle factors or diet gathered by an extensive PubMed search were carefully examined in order to explore their impact on the disease. Current authoritative knowledge confirms that low-calories, Mediterranean, and protein restricted/vegetarian diets may be beneficial. Psoriatic patients are also recommended to engage regular physical activity, to avoid alcohol intake and to consume fish rich in omega-3 polyunsaturated fatty acids, as well as fruit and vegetables. Prebiotics and probiotics may also provide potential benefit, whereas vitamin D supplementation and gluten-free diet are useful in selected cases only. Changing of dietary and lifestyle habits alone does not replace conventional treatment, but must be considered as an adjuvant. Physicians may play a crucial role, by adequately acknowledging psoriatic patients on the advantages of proper lifestyle and diet habits as well as providing clues to reliable sources of dietary advice.
C1 [Musumeci, Maria L.; Nasca, Maria R.; Boscaglia, Simona; Micali, Giuseppe] Univ Catania, Dermatol Clin, Catania, Italy.
C3 University of Catania
RP Micali, G (corresponding author), Univ Catania, Dermatol Clin, AOU Policlin G Rodolico San Marco, Via Santa Sofia 78, I-95123 Catania, Italy.
EM cldermct@gmail.com
RI Nasca, Maria Rita/ADN-9004-2022; Micali, Giuseppe/K-6848-2016; Musumeci,
   Maria Letizia/AAC-1898-2022
OI MICALI, Giuseppe/0000-0002-5157-3939
FU Universita degli Studi di Catania within the CRUI-CARE Agreement
FX Open Access Funding provided by Universita degli Studi di Catania within
   the CRUI-CARE Agreement.
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NR 55
TC 26
Z9 27
U1 3
U2 17
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1396-0296
EI 1529-8019
J9 DERMATOL THER
JI Dermatol. Ther.
PD SEP
PY 2022
VL 35
IS 9
AR e15685
DI 10.1111/dth.15685
EA JUL 2022
PG 9
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 4H4WC
UT WOS:000826282000001
PM 35790061
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Deng, N
   He, ZQ
   Guo, RX
   Zheng, BS
   Li, T
   Liu, RH
AF Deng, Na
   He, Ziqian
   Guo, Ruixue
   Zheng, Bisheng
   Li, Tong
   Liu, Rui Hai
TI Highland Barley Whole Grain (Hordeum vulgare L.)
   Ameliorates Hyperlipidemia by Modulating Cecal Microbiota, miRNAs, and
   AMPK Pathways in Leptin Receptor-Deficient db/db Mice
SO JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
LA English
DT Article
DE highland barley; whole grain; hyperlipidemia; cecal microbiota; AMPK
   pathway; miRNAs
ID BETA-GLUCAN; METABOLIC SYNDROME; LIPID PROFILE; FERULIC ACID; RATS;
   ANTIOXIDANT; ORYZANOL; NARINGIN; EXTRACT; RISK
AB The mechanisms of highland barley whole grain (BWG) with rich phenolics on obese db/db mice were investigated in this study. Oral consumption of BWG reduced food intake, body weight, organ/body weight indexes of liver and fat, levels of serum and hepatic lipids, liver injury, and oxidative stress. Furthermore, BWG recovered the disorder of cecal microbiota by augmenting the Bacteroidetes/Firmicutes ratio and Alistipes abundance and decreasing the abundances of Bacteroides and Desulfovibrionaceae to modulate lipid metabolism-related genes. BWG inhibited fatty acid biosynthesis via upregulating the phosphorylation of AMP-activated protein kinase alpha, while downregulating sterol regulatory element binding protein-1c, fatty acid synthase (FAS), and stearoyl-CoA desaturase 1 levels. BWG also significantly downregulated miRNA-122, miRNA-33, miRNA-34a, and miRNA-206 levels. Accordingly, BWG exhibited hypolipidemic potential through modulating cecal microbiota, AMPK/SREBP-1c/FAS pathway, and related miRNAs, triggering the alleviation of dyslipidemia. These findings suggested BWG as an effective candidate to ameliorate the symptoms of hyperlipidemia.
C1 [Deng, Na; He, Ziqian; Zheng, Bisheng] South China Univ Technol, Overseas Expertise Intro Ctr Discipline Innovat F, Ctr 111, Sch Food Sci & Engn, Guangzhou 510641, Peoples R China.
   [Guo, Ruixue] Guangdong Pharmaceut Univ, Sch Food Sci, Zhongshan 528458, Peoples R China.
   [Li, Tong; Liu, Rui Hai] Cornell Univ, Dept Food Sci, Ithaca, NY 14853 USA.
   [Zheng, Bisheng] Guangdong Era Food & Life Hlth Res Inst, Guangzhou 510670, Peoples R China.
C3 South China University of Technology; Guangdong Pharmaceutical
   University; Cornell University
RP Zheng, BS (corresponding author), South China Univ Technol, Overseas Expertise Intro Ctr Discipline Innovat F, Ctr 111, Sch Food Sci & Engn, Guangzhou 510641, Peoples R China.; Liu, RH (corresponding author), Cornell Univ, Dept Food Sci, Ithaca, NY 14853 USA.; Zheng, BS (corresponding author), Guangdong Era Food & Life Hlth Res Inst, Guangzhou 510670, Peoples R China.
EM febzheng@scut.edu.cn; RL23@cornell.edu
RI Deng, Na/ABH-6112-2020; Liu, Rui/AAE-4865-2019; li, tong/JYO-7530-2024
OI Zheng, Bisheng/0000-0003-1643-6493
FU 111 project [B17018]; Innovative Leading Talents Project of Guangzhou
   Development Zone; Guangdong Basic and Applied Basic Research Foundation
   [2020A1515011376]; Guangzhou Innovation Leading Talent Project; Natural
   Science Foundation of Guangdong Province, China
FX This work was supported by the 111 project (B17018), the Innovative
   Leading Talents Project of Guangzhou Development Zone, the Guangdong
   Basic and Applied Basic Research Foundation (2020A1515011376), the
   Guangzhou Innovation Leading Talent Project, and Natural Science
   Foundation of Guangdong Province, China.
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NR 45
TC 40
Z9 42
U1 8
U2 113
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0021-8561
EI 1520-5118
J9 J AGR FOOD CHEM
JI J. Agric. Food Chem.
PD OCT 21
PY 2020
VL 68
IS 42
BP 11735
EP 11746
DI 10.1021/acs.jafc.0c04780
PG 12
WC Agriculture, Multidisciplinary; Chemistry, Applied; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture; Chemistry; Food Science & Technology
GA OK9DG
UT WOS:000584943700012
PM 32985184
DA 2025-06-11
ER

PT J
AU Zeman, M
   Macásek, J
   Burda, M
   Tvrzická, E
   Vecka, M
   Krechler, T
   Stanková, B
   Hrabák, P
   Zák, A
AF Zeman, Miroslav
   Macasek, Jaroslav
   Burda, Michal
   Tvrzicka, Eva
   Vecka, Marek
   Krechler, Tomas
   Stankova, Barbora
   Hrabak, Petr, Jr.
   Zak, Ales
TI Chronic pancreatitis and the composition of plasma phosphatidylcholine
   fatty acids
SO PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
LA English
DT Article
DE Chronic pancreatitis; Fatty acid profile; Discriminant analysis;
   Diabetes mellitus; Malnutrition
ID CORONARY-ARTERY-DISEASE; DESATURASE ACTIVITY; METABOLIC SYNDROME;
   DIABETES-MELLITUS; ERYTHROCYTE-MEMBRANE; INSULIN-RESISTANCE; ANTIOXIDANT
   STATUS; OXIDATIVE STRESS; RISK-FACTORS; CANCER
AB Chronic pancreatitis (CP) is an irreversible inflammatory disorder characterized by the destruction of both exocrine and endocrine tissue. There is growing evidence that dysregulation of fatty acid (FA) metabolism is connected with many diseases; however, there are few data concerning FA composition in CP. Therefore, we analyzed FA profiles in plasma phosphatidyicholines in 96 patients with CP and in 108 control subjects (CON).
   The patients with CP had, in comparison with CON, increased sum of monounsaturated FA (EMUFA) and decreased content of polyunsaturated FA (PUFA) in both n-6 and n-3 families. Moreover, CP patients had increased indexes for delta-9, delta-6 desaturases, and fall in activity of delta-5 desaturase. Increased ratio of 16:1n-7/18:2n-6 (marker of essential n-6 FA deficiency), was more prevalent among CP patients.
   These changes implicated decreased fat intake, including n-3 as well as n-6 PUFA, and intrinsic changes in FA metabolism due to the alteration of delta desaturase activities. (C) 2016 Elsevier Ltd. All rights reserved.
C1 [Zeman, Miroslav; Macasek, Jaroslav; Tvrzicka, Eva; Vecka, Marek; Krechler, Tomas; Stankova, Barbora; Hrabak, Petr, Jr.; Zak, Ales] Charles Univ Prague, Gen Univ Hosp Prague, Fac Med 1, Dept Med 4, U Nemocnice 2, Prague 12808, Czech Republic.
   [Burda, Michal] Univ Ostrava, Inst Res & Applicat Fuzzy Modeling, CE IT4Innovat, Ostrava, Czech Republic.
C3 Charles University Prague; General University Hospital Prague;
   University of Ostrava
RP Vecka, M (corresponding author), Charles Univ Prague, Fac Med 1, Dept Med 4, Gen Univ Hosp Prague, U Nemocnice 2, Prague 12808, Czech Republic.
EM marek.vecka@lf1.cuni.cz
RI Zeman, Miroslav/J-5281-2016; Macasek, Jaroslav/G-8337-2016; Burda,
   Michal/D-6699-2014; Stankova, Barbora/L-7933-2016; Krechler,
   Tomas/H-4152-2016; Hrabak, Petr/Q-8220-2016; Zak, Ales/G-8318-2016;
   Tvrzicka, Eva/Q-6300-2016; Vecka, Marek/A-3560-2008
OI Zeman, Miroslav/0000-0001-5338-603X; Macasek,
   Jaroslav/0000-0002-8009-8970; Burda, Michal/0000-0002-4182-4407;
   Stankova, Barbora/0000-0002-6184-4878; Krechler,
   Tomas/0000-0003-4759-3037; Hrabak, Petr/0000-0002-7995-1081; Zak,
   Ales/0000-0002-1698-6068; Tvrzicka, Eva/0000-0003-0794-8454; Vecka,
   Marek/0000-0002-3269-1817
FU Ministry of Health of the Czech Republic (IGA) [RVO-VFN64165/2012,
   NT/13199]; Ministry of Education, Youth and Sports of the Czech Republic
   (Charles University in Prague) [PRVOUK-P25/LF1/2]; Ministry of
   Education, Youth and Sports of the Czech Republic (1st Faculty of
   Medicine); IT41I XS project [LQ1602]
FX Financial support from the Ministry of Health of the Czech Republic
   (project RVO-VFN64165/2012, and the grant NT/13199, IGA), the Ministry
   of Education, Youth and Sports of the Czech Republic (research project
   PRVOUK-P25/LF1/2 of Charles University in Prague, the 1st Faculty of
   Medicine) and the IT41I XS project number LQ1602 are gratefully
   acknowledged.
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NR 41
TC 13
Z9 14
U1 0
U2 13
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0952-3278
EI 1532-2823
J9 PROSTAG LEUKOTR ESS
JI Prostaglandins Leukot. Essent. Fatty Acids
PD MAY
PY 2016
VL 108
BP 38
EP 44
DI 10.1016/j.plefa.2016.03.012
PG 7
WC Biochemistry & Molecular Biology; Cell Biology; Endocrinology &
   Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology; Endocrinology &
   Metabolism
GA DM9VG
UT WOS:000376713200006
PM 27154363
DA 2025-06-11
ER

PT J
AU Si, HW
   Liu, DM
AF Si, Hongwei
   Liu, Dongmin
TI Dietary antiaging phytochemicals and mechanisms associated with
   prolonged survival
SO JOURNAL OF NUTRITIONAL BIOCHEMISTRY
LA English
DT Review
DE Aging; Phytochemicals; Calorie restriction; Reactive oxygen species;
   Inflammation; Autophagy
ID ACTIVATED PROTEIN-KINASE; LIFE-SPAN EXTENSION; FOXO TRANSCRIPTION
   FACTORS; NITRIC-OXIDE SYNTHASE; GREEN TEA CATECHINS; NF-KAPPA-B;
   SUPEROXIDE-DISMUTASE; METABOLIC SYNDROME; OXIDATIVE STRESS;
   SKELETAL-MUSCLE
AB Aging is well-known an inevitable process that is influenced by genetic, lifestyle and environmental factors. However, the exact mechanisms underlying the aging process are not well understood. Increasing evidence shows that aging is highly associated with chronic increase in reactive oxygen species (ROS), accumulation of a low-grade proinflammatory phenotype and reduction in age-related autophagy, suggesting that these factors may play important roles in promoting aging. Indeed, reduction of ROS and low-grade inflammation and promotion of autophagy by calorie restriction or other dietary manipulation can extend lifespan in a wide spectrum of model organisms. Interestingly, recent studies show that some food-derived small molecules, also called phytochemicals, can extend lifespan in various animal species. In this paper, we review several recently identified potential antiaging phytochemicals that have been studied in cells, animals and humans and further highlight the cellular and molecular mechanisms underlying the antiaging actions by these molecules. (C) 2014 Elsevier Inc. All rights reserved.
C1 [Si, Hongwei] Tennessee State Univ, Dept Family & Consumer Sci, Nashville, TN 37209 USA.
   [Liu, Dongmin] Virginia Tech, Coll Agr & Life Sci, Dept Human Nutr Foods & Exercise, Blacksburg, VA 24061 USA.
C3 Tennessee State University; Virginia Polytechnic Institute & State
   University
RP Si, HW (corresponding author), Tennessee State Univ, Dept Family & Consumer Sci, Nashville, TN 37209 USA.
EM hsi@tnstate.edu; doliu@vt.edu
FU National Institutes of Health (NIH)/National Center for Complementary
   and Alternative Medicine (NCCAM) grant [1R01AT007077-01]; American
   Diabetes Association (ADA) Basic Research award [7-11-BS-84]
FX This work was supported by the National Institutes of Health
   (NIH)/National Center for Complementary and Alternative Medicine (NCCAM)
   grant (1R01AT007077-01) and an American Diabetes Association (ADA) Basic
   Research award (7-11-BS-84). The contents of this manuscript are solely
   the responsibility of the authors and do not necessarily represent the
   official views of NCCAM or ADA.
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NR 209
TC 144
Z9 153
U1 1
U2 74
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0955-2863
EI 1873-4847
J9 J NUTR BIOCHEM
JI J. Nutr. Biochem.
PD JUN
PY 2014
VL 25
IS 6
BP 581
EP 591
DI 10.1016/j.jnutbio.2014.02.001
PG 11
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA AH8AD
UT WOS:000336355600001
PM 24742470
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Turan, Ç
   Kesebir, S
   Süner, Ö
AF Turan, Cetin
   Kesebir, Sermin
   Suner, Ozgur
TI Are ICAM, VCAM and E-selectin levels different in first manic episode
   and subsequent remission?
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Bipolar disorder; ICAM; VCAM; E-selectin; Atherosclerosis
ID CELL-ADHESION MOLECULES; BIPOLAR DISORDER; CARDIOVASCULAR-DISEASE;
   METABOLIC SYNDROME; RISK-FACTORS; PREVALENCE; SCHIZOPHRENIA;
   ASSOCIATION; MARKERS
AB Objective: In bipolar patients, the rate of mortality from cardiovascular diseases is two-fold higher than that in other psychiatric disorders. The risk of cardiovascular diseases was found to be associated with sonic cellular adhesion molecules: Intracellular adhesion molecule ([CAM), vascular cell adhesion molecule (VCAM) and E-selectin. The aim of this study was to compare [CAM, VCAM and E-selectin levels at first manic episode and subsequent remission period, and to investigate the presence of a relationship between adhesion molecules levels and clinical and metabolic variables.
   Methods: In line with this purpose, 50 patients diagnosed with mania according to DSM IV-TR criteria, who had their first episode were evaluated consecutively. The control group consisted of 50 healthy individuals without any history of psychiatric admission and treatment, matched with the manic patients in terms of age, gender, BMI and smoking status. For the confirmation of subsequent remission period (n=40), Young Mania Rating Scale and Hamilton Depression Rating Scale were used In three groups plasma ICAM, VCAM and E-selectin, fasting blood glucose, total cholesterol, LDL cholesterol, HDL cholesterol and triglyceride levels were measured and compared.
   Results: [CAM and VCAM levels were found to be higher in first manic episode than those in subsequent remission and healthy individuals. A weak correlation was found between [CAM levels and YMRS scores in manic patients. In first manic episode, a weak correlation was found between [CAM and total cholesterol and LDL cholesterol levels and a weak correlation was found between ICAM, VCAM and E-selectin levels and BMI.
   Conclusion: In the present study, which is the first investigation of proinflammatory and prothrombotic state, which is defined as a risk for metabolic syndrome and cardiovascular disease, in bipolar disorder, ICAM and VCAM levels were found to be higher in first episode mania than those in subsequent remission and healthy individuals. As the study group included first episode mani cases, there was no effect of chronic psychotropic use. Probable risk of cardiovascular disease, reflected by increased ICAM and VCAM levels is already present in bipolar patients at the onset of the disease. In addition, ICAM and VCAM levels increasing in manic episode, return to normal in the subsequent remission period. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Turan, Cetin; Kesebir, Sermin; Suner, Ozgur] Erenkoy Mental & Neurol Dis Training & Res Hosp, Istanbul, Turkey.
C3 Erenkoy Mental & Neurological Disorders Education & Research Hospital
RP Kesebir, S (corresponding author), Erenkoy Mental & Neurol Dis Training & Res Hosp, Sinan Ercan CN 29 Kadikoy, Istanbul, Turkey.
EM serminkesebir@hotmail.com
RI TURAN, CETIN/HHN-1721-2022
OI TURAN, CETIN/0000-0002-5259-6112
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NR 30
TC 16
Z9 18
U1 0
U2 6
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD JUL
PY 2014
VL 163
BP 76
EP 80
DI 10.1016/j.jad.2014.03.052
PG 5
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA AH9BS
UT WOS:000336435000011
PM 24836091
DA 2025-06-11
ER

PT J
AU Bi, JM
   Zhang, CM
   Lu, CH
   Mo, CZ
   Zeng, JW
   Yao, MY
   Jia, B
   Liu, ZJ
   Yuan, PY
   Xu, SM
AF Bi, Jiaming
   Zhang, Caimei
   Lu, Caihong
   Mo, Chuzi
   Zeng, Jiawei
   Yao, Mingyan
   Jia, Bo
   Liu, Zhongjun
   Yuan, Peiyan
   Xu, Shuaimei
TI Age-related bone diseases: Role of inflammaging
SO JOURNAL OF AUTOIMMUNITY
LA English
DT Article
DE Aging; Bone; Inflammaging; Cell senescence; Aging-related diseases
ID GINGIVAL CREVICULAR FLUID; C-REACTIVE PROTEIN; CELLULAR SENESCENCE;
   DNA-DAMAGE; SECRETORY PHENOTYPE; OXIDATIVE STRESS; METABOLIC SYNDROME;
   DIABETES-MELLITUS; IMMUNE-SYSTEM; OLDER-ADULTS
AB Bone aging is characterized by an imbalance in the physiological and pathological processes of osteogenesis, osteoclastogenesis, adipogenesis, and chondrogenesis, resulting in exacerbated bone loss and the development of age-related bone diseases, including osteoporosis, osteoarthritis, rheumatoid arthritis, and periodontitis. Inflammaging, a novel concept in the field of aging research, pertains to the persistent and gradual escalation of pro-inflammatory reactions during the aging process. This phenomenon is distinguished by its low intensity, systemic nature, absence of symptoms, and potential for management. The mechanisms by which inflammaging contribute to age-related chronic diseases, particularly in the context of age-related bone diseases, remain unclear. The precise manner in which systemic inflammation induces bone aging and consequently contributes to the development of age-related bone diseases has yet to be fully elucidated. This article primarily examines the mechanisms underlying inflammaging and its association with age-related bone diseases, to elucidate the potential mechanisms of inflammaging in age-related bone diseases and offer insights for developing preventive and therapeutic strategies for such conditions.
C1 [Bi, Jiaming; Zhang, Caimei; Lu, Caihong; Mo, Chuzi; Zeng, Jiawei; Liu, Zhongjun; Yuan, Peiyan; Xu, Shuaimei] Southern Med Univ, Stomatol Hosp, Sch Stomatol, Dept Endodont, Guangzhou, Guangdong, Peoples R China.
   [Jia, Bo] Southern Med Univ, Stomatol Hosp, Sch Stomatol, Dept Oral & Maxillofacial Surg, Guangzhou, Guangdong, Peoples R China.
   [Yao, Mingyan] Hebei Med Univ, Hosp 3, Dept Endocrinol, Shijiazhuang, Peoples R China.
   [Yao, Mingyan] Baoding 1 Cent Hosp, Dept Endocrinol, Baoding, Peoples R China.
C3 Southern Medical University - China; Southern Medical University -
   China; Hebei Medical University
RP Yuan, PY; Xu, SM (corresponding author), Southern Med Univ, Stomatol Hosp, Sch Stomatol, Dept Endodont, Guangzhou, Guangdong, Peoples R China.
EM peiyanyuan@163.com; xushuaimei@smu.edu.cn
RI Yuan, Peiyan/M-6040-2015; Zhang, Jun-Jie/AAD-8468-2019
FU Scientific Research and Cultivation Project of Stomatological Hospital,
   Southern Medical University [PY2021018, PY2022013]; Natural Science
   Foundation of Hebei Province [H2023104011]
FX This work was supported by Scientific Research and Cultivation Project
   of Stomatological Hospital, Southern Medical University (Grant no.,
   PY2021018 and PY2022013) . In addition, this work also received funding
   from Natural Science Foundation of Hebei Province. Award number :
   H2023104011.
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NR 281
TC 24
Z9 24
U1 29
U2 53
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 0896-8411
EI 1095-9157
J9 J AUTOIMMUN
JI J. Autoimmun.
PD FEB
PY 2024
VL 143
AR 103169
DI 10.1016/j.jaut.2024.103169
EA FEB 2024
PG 21
WC Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology
GA LD0J9
UT WOS:001184721900001
PM 38340675
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Singal, AK
   Shah, VH
   Malhi, H
AF Singal, Ashwani K.
   Shah, Vijay H.
   Malhi, Harmeet
TI Emerging targets for therapy in ALD: Lessons from NASH
SO HEPATOLOGY
LA English
DT Review
ID FATTY LIVER-DISEASE; ENDOPLASMIC-RETICULUM STRESS; ACTIVATED
   RECEPTOR-ALPHA; HEPATIC STEATOSIS; NONALCOHOLIC STEATOHEPATITIS;
   INSULIN-RESISTANCE; LIPID-METABOLISM; MURINE MODEL; DOUBLE-BLIND;
   ALCOHOL-USE
AB Alcohol-associated liver disease due to harmful alcohol use and NAFLD associated with metabolic syndrome are the 2 most common liver diseases worldwide. Control of respective risk factors is the cornerstone in the long-term management of these diseases. Furthermore, there are no effective therapies. Both diseases are characterized by metabolic derangements; thus, the focus of this review was to broaden our understanding of metabolic targets investigated in NAFLD, and how these can be applied to alcohol-associated liver disease. Conserved pathogenic pathways such as dysregulated lipid metabolism, cell death pathways including apoptosis and activation of innate immune cells, and stellate cells mediate both alcohol and NAFLDs, resulting in histological abnormalities of steatosis, inflammation, fibrosis, and cirrhosis. However, pathways such as gut microbiome changes, glucose metabolism and insulin resistance, inflammatory signaling, and microRNA abnormalities are distinct in these 2 diseases. In this review article, we describe conserved and distinct pathogenic pathways highlighting therapeutic targets that may be of potential in both diseases and those that are unique to each disease.
C1 [Singal, Ashwani K.] Univ South Dakota, Sanford Sch Med, Dept Internal Med, Sioux Falls, SD USA.
   [Singal, Ashwani K.] Avera Transplant Inst, Div Gastroenterol & Hepatol, Sioux Falls, SD USA.
   [Singal, Ashwani K.] VA Med Ctr, Sioux Falls, SD USA.
   [Shah, Vijay H.; Malhi, Harmeet] Mayo Clin, Div Gastroenterol & Hepatol, Rochester, MN USA.
   [Singal, Ashwani K.] Univ South Dakota, Sanford Sch Med, 1815 S Cliff Ave, Sioux Falls, SD 57105 USA.
C3 University of South Dakota; Mayo Clinic; University of South Dakota
RP Singal, AK (corresponding author), Univ South Dakota, Sanford Sch Med, 1815 S Cliff Ave, Sioux Falls, SD 57105 USA.
EM ashwanisingal.com@gmail.com; shah.vijay@mayo.edu; malhi.harmeet@mayo.edu
RI Singal, Ashwani/H-6181-2019
OI Singal, Ashwani/0000-0003-1207-3998; Malhi, Harmeet/0000-0002-0882-4990
FU National Institutes of Health [DK111378, AA21788]
FX Harmeet Malhi is supported by the National Institutes of Health
   (DK111378, AA21788). Vijay H. Shah is supported by the National
   Institutes of Health (AA21788).
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NR 119
TC 10
Z9 10
U1 3
U2 22
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0270-9139
EI 1527-3350
J9 HEPATOLOGY
JI Hepatology
PD JUL
PY 2024
VL 80
IS 1
BP 223
EP 237
DI 10.1097/HEP.0000000000000381
EA MAR 2023
PG 15
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA UZ3O2
UT WOS:001058657000001
PM 36938877
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Li, J
   Chen, QY
   Zhai, XM
   Wang, D
   Hou, YJ
   Tang, M
AF Li, Jie
   Chen, Qiyang
   Zhai, Xiuming
   Wang, Dan
   Hou, Yujia
   Tang, Min
TI Green tea aqueous extract (GTAE) prevents high-fat diet-induced obesity
   by activating fat browning
SO FOOD SCIENCE & NUTRITION
LA English
DT Article
DE BAT; browning; green tea; Ing-WAT; low-grade systemic inflammation;
   obesity
ID KAPPA-B ACTIVATION; ADIPOSE-TISSUE; NONALCOHOLIC STEATOHEPATITIS;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; MICE; CATECHINS; EXPRESSION;
   INFLAMMATION; OVERWEIGHT
AB Adipose browning leads to increased energy expenditure and reduced adiposity and has, therefore, become an attractive therapeutic strategy for obesity. In this study, we elucidated the effect of green tea aqueous extract (GTAE) on the browning of inguinal white adipose tissue (Ing-WAT) and brown adipose tissue (BAT) in high-fat diet (HFD)-fed mice. The main phytochemical components identified in GTAE through high-performance liquid chromatography (HPLC) included (-)-gallocatechin, (-)-epigallocatechin, (-)-catechin, (-)-epigallocatechin-3-gallate, caffeine, (-)-epicatechin, (-)-gallocatechin gallate, and (-)-epicatechin-3-gallate. Daily supplementation with 1% GTAE for 12 weeks markedly reduced bodyweight gain, systemic inflammation, oxidative stress, and improved insulin resistance. Additionally, histological analysis revealed that dietary supplementation with 1% GTAE reversed HFD-induced adipocyte size and hepatic steatosis. These effects were associated with activation of browning in the Ing-WAT and BAT, which mediate systemic metabolic dysfunction in HFD-fed mice. Taken together, our data support the use of GTAE, a natural product, for the attenuation of obesity through the activation of fat browning.
C1 [Li, Jie; Zhai, Xiuming; Hou, Yujia; Tang, Min] Chongqing Acad Agr Sci, Res Inst Tea, Chongqing 402160, Peoples R China.
   [Chen, Qiyang; Wang, Dan] Southwest Univ, Coll Hort & Landscape Architecture, Chongqing, Peoples R China.
C3 Chongqing Academy of Agricultural Sciences; Southwest University - China
RP Hou, YJ; Tang, M (corresponding author), Chongqing Acad Agr Sci, Res Inst Tea, Chongqing 402160, Peoples R China.
EM 564661213@qq.com; tangmin945@163.com
RI Tang, Min/KOC-3090-2024
FU Natural Science Foundation Project of Chongqing Science and Technology
   Bureau of Yongchuan District [2019nb0103]; Chongqing Science and
   Technology Commission Basic and Frontier Research Project
   [cstc2019jcyj-msxmX0553]
FX Natural Science Foundation Project of Chongqing Science and Technology
   Bureau of Yongchuan District, Grant/Award Number: Ycstc and 2019nb0103;
   Chongqing Science and Technology Commission Basic and Frontier Research
   Project, Grant/Award Number: cstc2019jcyj-msxmX0553
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NR 48
TC 4
Z9 5
U1 2
U2 31
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2048-7177
J9 FOOD SCI NUTR
JI Food Sci. Nutr.
PD DEC
PY 2021
VL 9
IS 12
BP 6548
EP 6558
DI 10.1002/fsn3.2580
EA OCT 2021
PG 11
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA XM1DN
UT WOS:000704204900001
PM 34925784
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Habtemariam, S
AF Habtemariam, Solomon
TI The Quest to Enhance the Efficacy of Berberine for Type-2 Diabetes and
   Associated Diseases: Physicochemical Modification Approaches
SO BIOMEDICINES
LA English
DT Review
DE nanoparticles; efflux; bioavailability; pharmacokinetics; synthesis;
   efficacy
ID ORAL BIOAVAILABILITY; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   SALACIA-CHINENSIS; SUSTAINED-RELEASE; OXIDATIVE STRESS; SOLID
   DISPERSION; DELIVERY-SYSTEM; MANGIFERIN; AMPK
AB Berberine is a quaternary isoquinoline alkaloid that has been isolated from numerous plants which are still in use today as medicine and herbal supplements. The great deal of enthusiasm for intense research on berberine to date is based on its diverse pharmacological effects via action on multiple biological targets. Its poor bioavailability resulting from low intestinal absorption coupled with its efflux by the action of P-glycoprotein is, however, the major limitation. In this communication, the chemical approach of improving berberine's bioavailability and pharmacological efficacy is scrutinised with specific reference to type-2 diabetes and associated diseases such as hyperlipidaemia and obesity. The application of modern delivery systems, research from combination studies to preparation of berberine structural hybrids with known biologically active compounds (antidiabetic, antihyperlipidaemic and antioxidant), as well as synthesis approaches of berberine derivative are presented. Improvement of bioavailability and efficacy through in vitro and ex vivo transport studies, as well as animal models of bioavailability/efficacy in lipid metabolism and diabetes targets are discussed.
C1 [Habtemariam, Solomon] Univ Greenwich, Pharmacognosy Res Labs, Chatham ME4 4TB, Kent, England.
   [Habtemariam, Solomon] Univ Greenwich, Herbal Anal Serv UK, Chatham ME4 4TB, Kent, England.
C3 University of Greenwich; University of Greenwich
RP Habtemariam, S (corresponding author), Univ Greenwich, Pharmacognosy Res Labs, Chatham ME4 4TB, Kent, England.; Habtemariam, S (corresponding author), Univ Greenwich, Herbal Anal Serv UK, Chatham ME4 4TB, Kent, England.
EM s.habtemariam@herbalanalysis.co.uk
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NR 121
TC 22
Z9 23
U1 1
U2 31
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2227-9059
J9 BIOMEDICINES
JI Biomedicines
PD APR
PY 2020
VL 8
IS 4
AR 90
DI 10.3390/biomedicines8040090
PG 19
WC Biochemistry & Molecular Biology; Medicine, Research & Experimental;
   Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Research & Experimental Medicine;
   Pharmacology & Pharmacy
GA LO5DG
UT WOS:000533647600028
PM 32325761
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Jamshidi, N
   Da Costa, C
   Cohen, M
AF Jamshidi, Negar
   Da Costa, Cliff
   Cohen, Marc
TI Holybasil (tulsi) lowers fasting glucose and improves lipid profile in
   adults with metabolic disease: A meta-analysis of randomized clinical
   trials
SO JOURNAL OF FUNCTIONAL FOODS
LA English
DT Article
DE Ayurveda; Cholesterol; Diabetes; Glucose; Ocimum sanctum; Metabolic
   disorders
ID TYPE-2 DIABETES-MELLITUS; OCIMUM-SANCTUM; LEAF POWDER; INSULIN;
   SUPPLEMENTATION; STRESS; LEAVES; ACID; CHOLESTEROL; PREVALENCE
AB Objective: To examine the effect of holy basil (tulsi) on metabolic syndrome parameters.
   Methods: Electronic database searches using relevant MeSH, free text terms and manual searches of the key references was performed up to August 2017. Study quality was evaluated using the Jadad scale. Effect size estimates were calculated as Mean Differences with 95% confidence interval(CI) using the random-effects model.
   Results: Consumption of tulsi significantly lowered mean fasting blood glucose [pooled MD: -15.69, 95% CI: -28.67 to -2.70; p = 0.02, I-2 = 91.22%] compared to control interventions. Subgroup analysis further revealed total, LDL and VLDL cholesterol levels were significantly reduced in older participants with metabolic disease.
   Conclusions: Short-term effects of tulsi as a single herb was effective at reducing fasting blood glucose. In older (>= 40 years) patients with metabolic disease tulsi supplementation at higher doses (>= 1 g/day) is associated with a reduction in total, LDL and VLDL cholesterol without changing overall lipid profiles.
C1 [Jamshidi, Negar; Cohen, Marc] RMIT Univ, Sch Hlth & Biomed Sci, Bundoora, Vic 3083, Australia.
   [Da Costa, Cliff] RMIT Univ, Sch Math & Geospatial Sci, Bundoora, Vic, Australia.
C3 Royal Melbourne Institute of Technology (RMIT); Royal Melbourne
   Institute of Technology (RMIT)
RP Cohen, M (corresponding author), RMIT Univ, Sch Hlth & Biomed Sci, Bundoora, Vic 3083, Australia.
EM marc.cohen@rmit.edu.au
RI Cohen, Marc/GWV-0933-2022; Jamshidi, Negar/J-6136-2019
OI Cohen, Marc/0000-0002-5876-6565; Jamshidi, Negar/0000-0003-2861-2140
FU RMIT University Scholarship
FX Negar Jamshidi is a Ph.D. student supported by an RMIT University
   Scholarship.
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NR 60
TC 6
Z9 6
U1 0
U2 5
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1756-4646
EI 2214-9414
J9 J FUNCT FOODS
JI J. Funct. Food.
PD JUN
PY 2018
VL 45
BP 47
EP 57
DI 10.1016/j.jff.2018.03.030
PG 11
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA GI6QB
UT WOS:000434494300006
DA 2025-06-11
ER

PT J
AU Houben, T
   Brandsma, E
   Walenbergh, SMA
   Hofker, MH
   Shiri-Sverdlov, R
AF Houben, T.
   Brandsma, E.
   Walenbergh, S. M. A.
   Hofker, M. H.
   Shiri-Sverdlov, R.
TI Oxidized LDL at the crossroads of immunity in non-alcoholic
   steatohepatitis
SO BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
LA English
DT Review
DE OxLDL; Lipid metabolism; Hepatic inflammation; NASH
ID LOW-DENSITY-LIPOPROTEIN; FATTY LIVER-DISEASE; HEPATIC STELLATE CELLS;
   SINUSOIDAL ENDOTHELIAL-CELLS; OXIDATIVE STRESS; GUT MICROBIOTA;
   VITAMIN-E; KUPFFER CELLS; LIPID-PEROXIDATION; PLANT STEROLS
AB Non-alcoholic steatohepatitis (NASH) is viewed as the hepatic manifestation of the metabolic syndrome and is a condition hallmarked by lipid accumulation in the liver (steatosis) along with inflammation (hepatitis). Currently, the etiology and mechanisms leading to obesity-induced hepatic inflammation are not clear and, as a consequence, strategies to diagnose or treat NASH in an accurate manner do not exist. In the current review, we put forward the concept of oxidized lipids as a significant risk factor for NASH. We will focus on the contribution of the different types of oxidized lipids as part of the oxidized low-density lipoprotein (oxLDL) to the hepatic inflammatory response. Furthermore, we will elaborate on the underlying mechanisms linking oxLDL to inflammatory responses in the liver and on how these cascades can be used as therapeutic targets to combat NASH. This article is part of a Special Issue entitled: Lipid modification and lipid peroxidation products in innate immunity and inflammation edited by Christoph J. Binder. (C) 2016 Elsevier B.V. All rights reserved.
C1 [Houben, T.; Walenbergh, S. M. A.; Shiri-Sverdlov, R.] Maastricht Univ, Sch Nutr & Translat Res Metab NUTRIM, Dept Mol Genet, Maastricht, Netherlands.
   [Brandsma, E.; Hofker, M. H.] Univ Groningen, Univ Med Ctr Groningen, Dept Pediat, Mol Genet Sect, NL-9700 AB Groningen, Netherlands.
C3 Maastricht University; University of Groningen
RP Shiri-Sverdlov, R (corresponding author), Maastricht Univ, Dept Mol Genet, POB 616, NL-6200 MD Maastricht, Netherlands.
EM r.sverdlov@maastrichtuniversity.nl
RI Shiri-Sverdlov, Ronit/X-2642-2019; Shiri-Sverdlov, Ronit/E-5571-2017;
   Houben, Tom/T-1083-2017
OI Shiri-Sverdlov, Ronit/0000-0002-6736-7814; Houben,
   Tom/0000-0002-0441-3166
FU Maag Lever Darm Stichting (MLDS) [WO 08-16, WO 11-35]; Netherlands
   Organisation for Scientific Research (NWO) [016.126.327, 015.008.043];
   Cardiovascular Research Netherlands (CVON) project IN-CONTROL [2012-03]
FX This research was supported by the Maag Lever Darm Stichting (MLDS) (WO
   08-16 and WO 11-35), the Netherlands Organisation for Scientific
   Research (NWO) (Vidi grant number: 016.126.327 and ASPASIA grant number:
   015.008.043) and the Cardiovascular Research Netherlands (CVON) project
   IN-CONTROL (2012-03).
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NR 210
TC 22
Z9 28
U1 0
U2 16
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1388-1981
EI 1879-2618
J9 BBA-MOL CELL BIOL L
JI Biochim. Biophys. Acta Mol. Cell Biol. Lipids
PD APR
PY 2017
VL 1862
IS 4
SI SI
BP 416
EP 429
DI 10.1016/j.bbalip.2016.07.008
PG 14
WC Biochemistry & Molecular Biology; Biophysics; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Cell Biology
GA EM3MC
UT WOS:000395218300007
PM 27472963
DA 2025-06-11
ER

PT J
AU Charytoniuk, T
   Drygalski, K
   Konstantynowicz-Nowicka, K
   Chabowski, A
AF Charytoniuk, Tomasz
   Drygalski, Krzysztof
   Konstantynowicz-Nowicka, Karolina
   Chabowski, Adrian
TI Alternative treatment methods attenuate the development of NAFLD: A
   review of resveratrol molecular mechanisms and clinical trials
SO NUTRITION
LA English
DT Review
DE Resveratrol; NAFLD; Liver steatosis; Clinical trials; Metabolism of
   resveratrol; Alternative NAFLD treatment
ID NONALCOHOLIC FATTY LIVER; NF-KAPPA-B; DIET-INDUCED STEATOHEPATITIS;
   OXIDATIVE STRESS; INSULIN-RESISTANCE; HEPATIC STEATOSIS; VITAMIN-E;
   METABOLIC SYNDROME; AMERICAN ASSOCIATION; LIPID-METABOLISM
AB Nonalcoholic fatty liver disease (NAFLD) is considered to be one of the most common liver pathologies that occur widely among societies with a predominance of the Western dietary pattern. NAFLD may progress from hepatic steatosis to nonalcoholic steatohepatitis (NASH), subsequently leading to cirrhosis and becoming a major cause of hepatocellular carcinoma. Thus its prevention and therapy play an important role in hepatology. To our knowledge, there is no effective treatment for patients with NAFLD. The aim of this review was to summarize the results of recent alternative treatment studies conducted both on cell cultures and in vivo that concern molecular effects of resveratrol (3,5,4'-trihydroxystilbene) in the treatment of NAFLD. The precise metabolism, pharmacology, and clinical trials with different concentrations of resveratrol were described. The review also presents a brief summary of other alternative treatment methods of NAFLD and their mechanisms compared with current clinical understanding. (C) 2016 Elsevier Inc. All rights reserved.
C1 [Charytoniuk, Tomasz; Drygalski, Krzysztof; Konstantynowicz-Nowicka, Karolina; Chabowski, Adrian] Med Univ Bialystok, Dept Physiol, Bialystok, Poland.
C3 Medical University of Bialystok
RP Drygalski, K (corresponding author), Med Univ Bialystok, Dept Physiol, Bialystok, Poland.
EM drygalskikrzysztof@gmail.com
RI ; Konstantynowicz-Nowicka, Karolina/T-9339-2018; Chabowski,
   Adrian/T-2225-2018
OI Drygalski, Krzysztof/0000-0003-0645-7020; Charytoniuk,
   Tomasz/0000-0002-4593-7476; Konstantynowicz-Nowicka,
   Karolina/0000-0001-9274-5488; Chabowski, Adrian/0000-0002-7407-8156
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TC 66
Z9 72
U1 4
U2 62
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0899-9007
EI 1873-1244
J9 NUTRITION
JI Nutrition
PD FEB
PY 2017
VL 34
BP 108
EP 117
DI 10.1016/j.nut.2016.09.001
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA EI4JP
UT WOS:000392460200015
PM 28063505
DA 2025-06-11
ER

PT J
AU Li, WD
   Saud, SM
   Young, MR
   Chen, GH
   Hua, BJ
AF Li, Weidong
   Saud, Shakir M.
   Young, Matthew R.
   Chen, Guohong
   Hua, Baojin
TI Targeting AMPK for cancer prevention and treatment
SO ONCOTARGET
LA English
DT Article
DE AMP activated kinase; cancer; prevention; treatment
ID ACTIVATED PROTEIN-KINASE; AUTOPHAGIC CELL-DEATH; SIGNALING PATHWAYS;
   CYCLOOXYGENASE-2 INHIBITOR; INDUCED APOPTOSIS; OXIDATIVE STRESS;
   LIVER-CANCER; IN-VITRO; METFORMIN; GROWTH
AB AMP-activated protein kinase (AMPK) is an important mediator in maintaining cellular energy homeostasis. AMPK is activated in response to a shortage of energy. Once activated, AMPK can promote ATP production and regulate metabolic energy. AMPK is a known target for treating metabolic syndrome and type-2 diabetes; however, recently AMPK is emerging as a possible metabolic tumor suppressor and target for cancer prevention and treatment. Recent epidemiological studies indicate that treatment with metformin, an AMPK activator reduces the incidence of cancer. In this article we review the role of AMPK in regulating inflammation, metabolism, and other regulatory processes with an emphasis on cancer, as well as, discuss the potential for targeting AMPK to treat various types of cancer. Activation of AMPK has been found to oppose tumor progression in several cancer types and offers a promising cancer therapy. This review evaluates the evidence linking AMPK with tumor suppressor function and analyzes the molecular mechanisms involved. AMPK activity opposes tumor development and progression in part by regulating inflammation and metabolism.
C1 [Li, Weidong; Hua, Baojin] China Acad Chinese Med Sci, Guanganmen Hosp, Dept Oncol, Beijing, Peoples R China.
   [Saud, Shakir M.] NCI, Nutr Sci Res Grp, Canc Prevent Div, NIH, Rockville, MD USA.
   [Li, Weidong; Saud, Shakir M.; Young, Matthew R.] NCI, Basic Res Lab, Ctr Canc Res, NIH, Frederick, MD 21701 USA.
   [Chen, Guohong] China Acad Chinese Med Sci, Guanganmen Hosp, Dept Urinary Surg, Beijing, Peoples R China.
C3 Guang'anmen Hospital, CACMS; China Academy of Chinese Medical Sciences;
   National Institutes of Health (NIH) - USA; NIH National Cancer Institute
   (NCI); National Institutes of Health (NIH) - USA; NIH National Cancer
   Institute (NCI); Guang'anmen Hospital, CACMS; China Academy of Chinese
   Medical Sciences
RP Hua, BJ (corresponding author), China Acad Chinese Med Sci, Guanganmen Hosp, Dept Oncol, Beijing, Peoples R China.
EM cghdoctor@sina.com; dr.huabaojin@hotmail.com
FU National Natural Science Foundation of China [81273718, 81102587]; China
   Postdoctoral Science Foundation [2012T50199]
FX Weidong Li and Shakir M. Saud contributed equally to this work and
   should be considered co-first authors. This work was partly supported by
   National Natural Science Foundation of China (No.81273718 and 81102587)
   and China Postdoctoral Science Foundation (No. 2012T50199).
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NR 145
TC 285
Z9 301
U1 0
U2 35
PU IMPACT JOURNALS LLC
PI ORCHARD PARK
PA 6666 E QUAKER ST, STE 1, ORCHARD PARK, NY 14127 USA
EI 1949-2553
J9 ONCOTARGET
JI Oncotarget
PD APR 10
PY 2015
VL 6
IS 10
BP 7365
EP 7378
DI 10.18632/oncotarget.3629
PG 14
WC Oncology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Cell Biology
GA CI6QJ
UT WOS:000354885300002
PM 25812084
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Cárdeno, A
   Sánchez-Hidalgo, M
   Alarcón-de-la-Lastra, C
AF Cardeno, A.
   Sanchez-Hidalgo, M.
   Alarcon-de-la-Lastra, C.
TI An Up-date of Olive Oil Phenols in Inflammation and Cancer: Molecular
   Mechanisms and Clinical Implications
SO CURRENT MEDICINAL CHEMISTRY
LA English
DT Article
DE Cancer; inflammation; olive oil; oxidative stress; phenols
ID OXIDATIVE DNA-DAMAGE; METABOLIC SYNDROME; IN-VITRO; HYDROXYTYROSOL
   PROTECTS; ANTIOXIDANT ACTIVITY; OLEUROPEIN AGLYCONE; LIPID-PEROXIDATION;
   CEREBRAL-ISCHEMIA; COX-2 EXPRESSION; GENE-EXPRESSION
AB Olive oil (OO), the main fatty component of the Mediterranean diet, exhibits numerous biological functions which are beneficial for the state of health. In addition to monounsaturated fatty acid (MUFA) evidences have accumulated on the favorable properties of its minor though highly bioactive components, particularly the phenolic compounds, which have shown a broad spectrum of bioactive properties, including antioxidant and anti-inflammatory effects both associated with the origin of the main chronic diseases. Additional studies have demonstrated that the health effects of olive oil polyphenols have been also associated with their, neuroprotective, antiaging and antiatherogenic effects. On the other hand, because of their ability to modulate cell death, olive polyphenols have been proposed as chemopreventive and therapeutic agents. Thus, the purpose of this article is to review the chemistry, bioavailability and pharmacokinetic characteristics of OO polyphenols, in addition to provide the reader an up-date of their putative antioxidant, anti-inflammatory and anti-cancer activities as well as the plausible action mechanisms involved.
C1 [Cardeno, A.; Sanchez-Hidalgo, M.; Alarcon-de-la-Lastra, C.] Univ Seville, Fac Pharm, Dept Pharmacol, Seville, Spain.
C3 University of Sevilla
RP Alarcón-de-la-Lastra, C (corresponding author), Univ Seville, Fac Pharm, Dept Pharmacol, Seville, Spain.
RI Sanchez-Hidalgo, Marina/E-9231-2010; Alarcon-de-la-Lastra,
   Catalina/F-6282-2013
OI Sanchez-Hidalgo, Marina/0000-0002-9210-2404; Alarcon-de-la-Lastra,
   Catalina/0000-0001-6625-3818; Cardeno Galvan, Ana/0000-0003-4426-2259
FU Spanish Ministerio de Ciencia e Innovacion [AGL 2008-02475, AGL
   2011-26949]; Junta de Andalucia; Postgraduate National Program of FPU
   fellowship; Spanish Ministerio de Educacion
FX This work was supported by funds from the Spanish Ministerio de Ciencia
   e Innovacion (AGL 2008-02475, AGL 2011-26949) and Junta de Andalucia. AC
   gratefully acknowledges support from a Postgraduate National Program of
   FPU fellowship and financial sponsorship from the Spanish Ministerio de
   Educacion.
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NR 144
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U1 0
U2 42
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 0929-8673
EI 1875-533X
J9 CURR MED CHEM
JI Curr. Med. Chem.
PD DEC
PY 2013
VL 20
IS 37
BP 4758
EP 4776
DI 10.2174/09298673113209990159
PG 19
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Pharmacology &
   Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
GA 258FS
UT WOS:000327445300009
PM 23834184
DA 2025-06-11
ER

PT J
AU Husseini, A
   Abu-Rmeileh, NME
   Mikki, N
   Ramahi, TM
   Abu Ghosh, H
   Barghuthi, N
   Khalili, M
   Bjertness, E
   Holmboe-Ottesen, G
   Jervell, J
AF Husseini, Abdullatif
   Abu-Rmeileh, Niveen M. E.
   Mikki, Nahed
   Ramahi, Tarik M.
   Abu Ghosh, Heidar
   Barghuthi, Nadim
   Khalili, Mohammad
   Bjertness, Espen
   Holmboe-Ottesen, Gerd
   Jervell, Jak
TI Health in the Occupied Palestinian Territory 3 Cardiovascular diseases,
   diabetes mellitus, and cancer in the occupied Palestinian territory
SO LANCET
LA English
DT Article
ID CORONARY-HEART-DISEASE; PREVENTING CHRONIC DISEASES;
   UNIVERSITY-STUDENTS; MEDITERRANEAN DIET; METABOLIC SYNDROME;
   PUBLIC-HEALTH; RISK-FACTORS; OBESITY; ADOLESCENTS; UNDERNUTRITION
AB Heart disease, cerebrovascular disease, and cancer are the major causes of morbidity and mortality in the occupied Palestinian territory, resulting in a high direct cost of care, high indirect cost in loss of production, and much societal stress. The rates of the classic risk factors for atherosclerotic disease-namely, hypertension, diabetes mellitus, tobacco smoking, and dyslipidaemia-are high and similar to those in neighbouring countries. The urbanisation and continuing nutritional change from a healthy Mediterranean diet to an increasingly western-style diet is associated with reduced activity, obesity and a loss of the protective effect of the traditional diet. Rates of cancer seem to be lower than those in neighbouring countries, with the leading causes of death being lung cancer in Palestinian men and breast cancer in women. The response of society and the health-care system to this epidemic is inadequate. A large proportion of health-care expenditure is on expensive curative care outside the area. Effective comprehensive prevention programmes should be implemented, and the health-care system should be redesigned to address these diseases.
C1 [Husseini, Abdullatif; Abu-Rmeileh, Niveen M. E.; Mikki, Nahed] Birzeit Univ, Inst Community & Publ Hlth, POB 14, Birzeit, Israel.
   [Mikki, Nahed; Bjertness, Espen; Holmboe-Ottesen, Gerd; Jervell, Jak] Univ Oslo, Inst Gen Practice & Community Med, Oslo, Norway.
   [Ramahi, Tarik M.] Yale Univ, Council Middle E Studies, New Haven, CT USA.
   [Abu Ghosh, Heidar] Palestinian Med Relief Soc, Chron Dis Ctr, Ramallah, Palestine.
   [Barghuthi, Nadim] Minist Hlth, Dept Noncommunicable dis, Ramallah, Palestine.
   [Khalili, Mohammad] UN, Relief & Works Agcy, Jerusalem, Israel.
   [Bjertness, Espen] Tibet Univ, Coll Med, Lhasa, Peoples R China.
C3 Birzeit University; University of Oslo; Yale University; Tibet
   University
RP Husseini, A (corresponding author), Birzeit Univ, Inst Community & Publ Hlth, POB 14, Birzeit, Israel.
EM abdullatif@birzeit.edu
RI Husseini, Abdullatif/E-8377-2015; Bjertness, Espen/LBH-4851-2024;
   Abu-Rmeileh, Niveen/H-7135-2019
OI Mikki, Nahed/0000-0003-0947-2146; Husseini,
   Abdullatif/0000-0001-8767-5956
FU Norwegian Programme for Development, Research and Education
FX We thank the Lancet Palestine Steering Group (lain Chalmers, Rita
   Giacaman, Jennifer Leaning, Harry Shannon, and Huda Zurayk) for reading,
   discussing, and commenting on several drafts of this report; Graham
   Watt, and Karl Sabbagh for their valuable comments and support; Medical
   Aid for Palestinians UK, University of Oslo, Institute for General
   Practice and Community Medicine, and the Norwegian Programme for
   Development, Research and Education for their financial contributions
   that made the workshops related to this Series possible; and the
   reviewers ofthis report, whose comments improved this final draft
   substantially for their support and valuable advice.
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   BTSELEM SEPARATION B
NR 80
TC 103
Z9 106
U1 2
U2 10
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0140-6736
EI 1474-547X
J9 LANCET
JI Lancet
PD MAR 21
PY 2009
VL 373
IS 9668
BP 1041
EP 1049
DI 10.1016/S0140-6736(09)60109-4
PG 9
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 422AA
UT WOS:000264398200032
PM 19268350
DA 2025-06-11
ER

PT J
AU Ashonibare, VJ
   Akorede, BA
   Ashonibare, PJ
   Akhigbe, TM
   Akhigbe, RE
AF Ashonibare, Victory J.
   Akorede, Bolaji A.
   Ashonibare, Precious J.
   Akhigbe, Tunmise M.
   Akhigbe, Roland Eghoghosoa
TI Gut microbiota-gonadal axis: the impact of gut microbiota on
   reproductive functions
SO FRONTIERS IN IMMUNOLOGY
LA English
DT Review
DE gut microbiota; infertility; inflammation; insulin resistance;
   microbiome; oxidative stress
ID SEGMENTED FILAMENTOUS BACTERIA; IRRITABLE-BOWEL-SYNDROME;
   AKKERMANSIA-MUCINIPHILA; FECAL MICROBIOTA; COLONIC MUCUS; INSULIN
   SENSITIVITY; METABOLIC SYNDROME; SPERM QUALITY; IMMUNE-SYSTEM;
   INFLAMMATION
AB The influence of gut microbiota on physiological processes is rapidly gaining attention globally. Despite being under-studied, there are available data demonstrating a gut microbiota-gonadal cross-talk, and the importance of this axis in reproduction. This study reviews the impacts of gut microbiota on reproduction. In addition, the possible mechanisms by which gut microbiota modulates male and female reproduction are presented. Databases, including Embase, Google scholar, Pubmed/Medline, Scopus, and Web of Science, were explored using relevant key words. Findings showed that gut microbiota promotes gonadal functions by modulating the circulating levels of steroid sex hormones, insulin sensitivity, immune system, and gonadal microbiota. Gut microbiota also alters ROS generation and the activation of cytokine accumulation. In conclusion, available data demonstrate the existence of a gut microbiota-gonadal axis, and role of this axis on gonadal functions. However, majority of the data were compelling evidences from animal studies with a great dearth of human data. Therefore, human studies validating the reports of experimental studies using animal models are important.
C1 [Ashonibare, Victory J.] Leibniz Inst Nat Prod Res & Infect Biol, Dept Infect Biol, Jena, Germany.
   [Ashonibare, Victory J.] Friedrich Schiller Univ, Inst Microbiol, Jena, Germany.
   [Ashonibare, Victory J.; Akorede, Bolaji A.; Ashonibare, Precious J.; Akhigbe, Tunmise M.; Akhigbe, Roland Eghoghosoa] Oasis Grace Hosp, Reprod Biol & Toxicol Res Lab, Osogbo, Nigeria.
   [Akorede, Bolaji A.] Univ Wyoming, Plant Sci Dept, Laramie, WY USA.
   [Ashonibare, Precious J.; Akhigbe, Roland Eghoghosoa] Ladoke Akintola Univ Technol, Dept Physiol, Ogbomosho, Oyo, Nigeria.
   [Akhigbe, Tunmise M.] Osun State Univ, Dept Agron, Breeding & Genet Unit, Ejigbo, Osun, Nigeria.
C3 Leibniz Association; Hans Knoll Institute (HKI); Friedrich Schiller
   University of Jena; University of Wyoming
RP Akhigbe, RE (corresponding author), Oasis Grace Hosp, Reprod Biol & Toxicol Res Lab, Osogbo, Nigeria.; Akhigbe, RE (corresponding author), Ladoke Akintola Univ Technol, Dept Physiol, Ogbomosho, Oyo, Nigeria.
EM akhigberoland@gmail.com
RI Akorede, Bolaji/LDF-2008-2024
OI Akorede, Bolaji/0000-0001-6465-6701
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NR 204
TC 17
Z9 17
U1 17
U2 47
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-3224
J9 FRONT IMMUNOL
JI Front. Immunol.
PD FEB 28
PY 2024
VL 15
AR 1346035
DI 10.3389/fimmu.2024.1346035
PG 14
WC Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology
GA KT3J5
UT WOS:001182173700001
PM 38482009
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Chen, L
   Jiang, QH
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AF Chen, Lin
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   Tan, Chin Ping
   Xiang, Xingwei
   Shen, Guoxin
TI Sciadonic acid ameliorates cyclophosphamide-induced immunosuppression by
   modulating the immune response and altering the gut microbiota
SO JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
LA English
DT Article
DE cyclophosphamide; gut microbiota; immunomodulatory activity; intestinal
   barrier; sciadonic acid
ID PROTECTS
AB BACKGROUNDCyclophosphamide (Cy) is a frequently used chemotherapeutic drug, but long-term Cy treatment can cause immunosuppression and intestinal mucosal damage. The intestinal mucosal barrier and gut flora play important roles in regulating host metabolism, maintaining physiological functions and protecting immune homeostasis. Dysbiosis of the intestinal flora affects the development of the intestinal microenvironment, as well as the development of various external systemic diseases and metabolic syndrome.RESULTSThe present study investigated the influence of sciadonic acid (SA) on Cy-induced immunosuppression in mice. The results showed that SA gavage significantly alleviated Cy-induced immune damage by improving the immune system organ index, immune response and oxidative stress. Moreover, SA restored intestinal morphology, improved villus integrity and activated the nuclear factor kappa B signaling pathway, stimulated cytokine production, and reduced serum lipopolysaccharide (LPS) levels. Furthermore, gut microbiota analysis indicated that SA increased t beneficial bacteria (Alistipes, Lachnospiraceae_NK4A136_group, Rikenella and Odoribacter) and decreased pathogenic bacteria (norank-f-Oscillospiraceae, Ruminococcus and Desulfovibrio) to maintain intestinal homeostasis.CONCLUSIONThe present study provided new insights into the SA regulation of intestinal flora to enhance immune responses. (c) 2024 Society of Chemical Industry.
C1 [Chen, Lin; Jiang, Qihong; Jiang, Chenkai; Lu, Hongling; Hu, Wenjun; Yu, Shaofang; Shen, Guoxin] Zhejiang Acad Agr Sci, Inst Sericultural & Tea, Hangzhou 310021, Peoples R China.
   [Yao, Shiwei; Xiang, Xingwei] Zhejiang Univ Technol, Coll Food Sci & Technol, Hangzhou 310014, Peoples R China.
   [Li, Mingqian] Tongde Hosp Zhejiang Prov, Zhejiang Acad Tradit Chinese Med, Zhejiang Prov Key Lab Canc Prevent & Treatment Tec, Hangzhou, Peoples R China.
   [Feng, Yongcai; Tan, Chin Ping] Zhuji Lvkang Biotechnol Co Ltd, Shaoxing, Peoples R China.
C3 Zhejiang Academy of Agricultural Sciences; Zhejiang University of
   Technology
RP Shen, GX (corresponding author), Zhejiang Acad Agr Sci, Inst Sericultural & Tea, Hangzhou 310021, Peoples R China.; Xiang, XW (corresponding author), Zhejiang Univ Technol, Coll Food Sci & Technol, Hangzhou 310014, Peoples R China.
EM xxw11086@zjut.edu.cn; guoxin.shen@ttu.edu
RI Chen, Lin/G-3516-2013; Shen, Guoxin/GPT-2191-2022; Jiang,
   Chenkai/AAG-8077-2021; L, mq/ITR-8440-2023; Tan, Chin Ping/A-8130-2008
OI Tan, Chin Ping/0000-0003-4177-4072; Chen, Lin/0000-0002-6727-0529
FU the grants from Development of deep-processed products of Torreya and
   Evaluation of Functional Active Substances (2021R06B88D02) [202208CL,
   2021R06B88D02]; Foundation of Key Laboratory of Cancer Prevention and
   Therapy Combining Traditional Chinese and Western Medicine of Zhejiang
   Province [2021 K34]; Project of Science and Technology Program of Quzhou
FX This work was supported by the Foundation of Key Laboratory of Cancer
   Prevention and Therapy Combining Traditional Chinese and Western
   Medicine of Zhejiang Province (202208CL), grants from Development of
   deep-processed products of Torreya and Evaluation of Functional Active
   Substances (2021R06B88D02) and the Project of Science and Technology
   Program of Quzhou (no. 2021 K34).
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NR 49
TC 3
Z9 3
U1 8
U2 24
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-5142
EI 1097-0010
J9 J SCI FOOD AGR
JI J. Sci. Food Agric.
PD MAY
PY 2024
VL 104
IS 7
BP 3902
EP 3912
DI 10.1002/jsfa.13271
EA JAN 2024
PG 11
WC Agriculture, Multidisciplinary; Chemistry, Applied; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture; Chemistry; Food Science & Technology
GA NI6S0
UT WOS:001147517700001
PM 38264943
DA 2025-06-11
ER

PT J
AU Li, W
   Liu, JY
   Cai, JJ
   Zhang, XJ
   Zhang, P
   She, ZG
   Chen, SZ
   Li, HL
AF Li, Wei
   Liu, Jiayi
   Cai, Jingjing
   Zhang, Xiao-jing
   Zhang, Peng
   She, Zhi-gang
   Chen, Shaoze
   Li, Hongliang
TI NAFLD as a continuous driver in the whole spectrum of vascular disease
SO JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
LA English
DT Review
DE Vascular health; NAFLD; Early vascular damage; Cardiovascular event;
   Endothelial dysfunction; Atherosclerosis
ID FATTY LIVER-DISEASE; CORONARY-ARTERY CALCIFICATION;
   LOW-DENSITY-LIPOPROTEIN; INCIDENT CARDIOVASCULAR-DISEASE; INTIMA-MEDIA
   THICKNESS; INSULIN-RESISTANCE; HEPATIC STEATOSIS; METABOLIC SYNDROME;
   CAROTID ATHEROSCLEROSIS; ENDOTHELIAL DYSFUNCTION
AB Vascular disease is the prime determinant to cardiovascular morbidities and mortalities, which comprises the early vascular damage and subsequent cardiovascular events. Non-alcohol Fatty Liver Disease (NAFLD) is a systemic metabolic disorder that drives the progression of vascular disease through complex interactions. Although a causal relationship between NAFLD and cardiovascular disease (CVD) has not been established, a growing number of epidemiological studies have demonstrated an independent association between NAFLD and early vascular disease and subsequent cardiovascular events. In addition, mechanistic studies suggest that NAFLD initiates and accelerates vascular injury by increasing systemic inflammation and oxidative stress, impairing insulin sensitivity and lipid metabolism, and modulating epigenetics, the intestinal flora and hepatic autonomic nervous system; thus, NAFLD is a putative driving force for CVD progression. In this review, we summarize the clinical evidence supporting the association of NAFLD with subclinical vascular disease and cardiovascular events and discuss the potential mechanisms by which NAFLD promotes the progression of vascular disease.
C1 [Li, Wei; Liu, Jiayi; She, Zhi-gang; Li, Hongliang] Wuhan Univ, Renmin Hosp, Dept Cardiol, Wuhan 430072, Peoples R China.
   [Li, Wei; Liu, Jiayi; Cai, Jingjing; Zhang, Xiao-jing; Zhang, Peng; She, Zhi-gang; Li, Hongliang] Wuhan Univ, Inst Model Anim, Wuhan, Peoples R China.
   [Cai, Jingjing] Cent South Univ, Xiangya Hosp 3, Dept Cardiol, Changsha, Peoples R China.
   [Zhang, Xiao-jing; Zhang, Peng; Li, Hongliang] Wuhan Univ, Sch Basic Med Sci, Wuhan, Peoples R China.
   [Chen, Shaoze] Huanggang Cent Hosp, Dept Cardiol, Kaopeng Rd, Huanggang 438021, Peoples R China.
   [Chen, Shaoze] Huanggang Inst Translat Med, Huanggang, Peoples R China.
C3 Wuhan University; Wuhan University; Central South University; Wuhan
   University
RP She, ZG; Li, HL (corresponding author), Wuhan Univ, Renmin Hosp, Dept Cardiol, Wuhan 430072, Peoples R China.; Chen, SZ (corresponding author), Huanggang Cent Hosp, Dept Cardiol, Kaopeng Rd, Huanggang 438021, Peoples R China.
EM zgshe@whu.edu.cn; chrmshaoze@hgyy.org.cn; lihl@whu.edu.cn
RI Chen, Shaoze/GLU-9377-2022; Cai, Jingjing/JXN-8391-2024; jiayi,
   liu/JMQ-9878-2023; Li, Wei/LSL-0298-2024; She, Zhi-Gang/AFP-9194-2022
OI She, Zhi-Gang/0000-0001-9402-4166
FU National Key R&D Program of China [2016YFF0101504, 2020YFC2004702];
   National Science Foundation of China [81630011, 81970364, 81970070,
   81770053, 81870171, 81970011]; Hubei Science and Technology Support
   Project [2019BFC582, 2018BEC473]; Medical flight plan of Wuhan
   University [TFJH2018006]
FX This work was supported by grants from the National Key R&D Program of
   China (2016YFF0101504, 2020YFC2004702), the National Science Foundation
   of China (81630011, 81970364, 81970070, 81770053, 81870171, 81970011),
   the Hubei Science and Technology Support Project (2019BFC582,
   2018BEC473), and Medical flight plan of Wuhan University (TFJH2018006).
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NR 174
TC 20
Z9 21
U1 4
U2 45
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 0022-2828
EI 1095-8584
J9 J MOL CELL CARDIOL
JI J. Mol. Cell. Cardiol.
PD FEB
PY 2022
VL 163
BP 118
EP 132
DI 10.1016/j.yjmcc.2021.10.007
EA NOV 2021
PG 15
WC Cardiac & Cardiovascular Systems; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Cell Biology
GA WW7GU
UT WOS:000718081000006
PM 34737121
DA 2025-06-11
ER

PT J
AU Khan, J
   Al Asoom, LI
   Al Sunni, A
   Rafique, N
   Latif, R
   Al Saif, S
   Almandil, NB
   Almohazey, D
   AbdulAzeez, S
   Borgio, JF
AF Khan, Johra
   Al Asoom, Lubna Ibrahim
   Al Sunni, Ahmad
   Rafique, Nazish
   Latif, Rabia
   Al Saif, Seham
   Almandil, Noor B.
   Almohazey, Dana
   AbdulAzeez, Sayed
   Borgio, J. Francis
TI Genetics, pathophysiology, diagnosis, treatment, management, and
   prevention of migraine
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Review
DE Migraine; Pathophysiology; Endocrine; Metabolic syndrome; Diagnosis;
   Genetics
ID COMPUTERIZED AXIAL-TOMOGRAPHY; ISOLATED BLOOD-VESSELS; DOUBLE-BLIND;
   AMERICAN MIGRAINE; OXIDATIVE STRESS; CHRONIC HEADACHE; GLOBAL BURDEN;
   UNITED-STATES; SODIUM-INTAKE; CT-SCANS
AB Migraine is a neurological ailment that is characterized by severe throbbing unilateral headache and associated with nausea, photophobia, phonophobia and vomiting. A full and clear mechanism of the pathogenesis of migraine, though studied extensively, has not been established yet. The current available information indicates an intracranial network activation that culminates in the sensitization of the trigemino-vascular system, release of inflammatory markers, and initiation of meningeal-like inflammatory reaction that is sensed as headache. Genetic factors might play a significant role in deciding an individual's susceptibility to migraine. Twin studies have revealed that a single gene polymorphism can lead to migraine in individuals with a monogenic migraine disorder. In this review, we describe recent advancements in the genetics, pathophysiology, diagnosis, treatment, management, and prevention of migraine. We also discuss the potential roles of genetic and abnormal factors, including some of the metabolic triggering factors that result in migraine attacks. This review will help to accumulate current knowledge about migraine and understanding of its pathophysiology, and provides up-todate prevention strategies.
C1 [Khan, Johra] Majmaah Univ, Coll Appl Med Sci, Dept Med Lab Sci, Majmaah 11952, Saudi Arabia.
   [Al Asoom, Lubna Ibrahim; Al Sunni, Ahmad; Rafique, Nazish; Latif, Rabia; Al Saif, Seham] Imam Abdulrahman Bin Faisal Univ, Coll Med, Dept Physiol, Dammam 31541, Saudi Arabia.
   [Almandil, Noor B.] Imam Abdulrahman Bin Faisal Univ, Inst Res & Med Consultat IRMC, Dept Clin Pharm Res, Dammam 31441, Saudi Arabia.
   [Almohazey, Dana] Imam Abdulrahman Bin Faisal Univ, Inst Res & Med Consultat IRMC, Dept Stem Cell Res, Dammam 31441, Saudi Arabia.
   [AbdulAzeez, Sayed; Borgio, J. Francis] Imam Abdulrahman Bin Faisal Univ, Inst Res & Med Consultat IRMC, Dept Genet Res, Dammam 31441, Saudi Arabia.
   [Borgio, J. Francis] Imam Abdulrahman Bin Faisal Univ, Inst Res & Med Consultat IRMC, Dept Epidem Dis Res, Dammam 31441, Saudi Arabia.
C3 Majmaah University; Imam Abdulrahman Bin Faisal University; Imam
   Abdulrahman Bin Faisal University; Imam Abdulrahman Bin Faisal
   University; Imam Abdulrahman Bin Faisal University; Imam Abdulrahman Bin
   Faisal University
RP Al Asoom, LI (corresponding author), Imam Abdulrahman Bin Faisal Univ, Coll Med, Dept Physiol, Dammam 31541, Saudi Arabia.; Borgio, JF (corresponding author), Imam Abdulrahman Bin Faisal Univ, Inst Res & Med Consultat IRMC, Dept Genet Res, Dammam 31441, Saudi Arabia.
EM j.khan@mu.edu.sa; lasoom@iau.edu.sa; aalsunni@iau.edu.sa;
   nryahmed@iau.edu.sa; rlhussain@iau.edu.sa; ssalsaif@iau.edu.sa;
   nbalmandil@iau.edu.sa; daaalmohazey@iau.edu.sa; asayed@iau.edu.sa;
   fbalexander@iau.edu.sa
RI Almohazey, Dana/D-8048-2017; Asoom, Lubna/V-2977-2019; Almandil,
   Noor/A-3533-2015; Latif, Rabia/AAD-9024-2021; Alsaif,
   Seham/AGG-7270-2022; Khan, Dr Johra/AAW-3957-2020; Borgio, J
   Francis/P-5586-2014; AbdulAzeez, Sayed/I-6770-2019; Rafique,
   Nazish/HSE-5177-2023
OI Alsunni, Ahmed A/0000-0001-5402-1091; Borgio, J
   Francis/0000-0001-7199-1540; , Rabia Latif/0000-0001-6489-5809;
   AbdulAzeez, Sayed/0000-0002-9763-9446; Rafique,
   Nazish/0000-0002-1565-415X
FU Deanship of Scientific Research [IFP-2020-46]; Majmaah University,
   Al-Majmaah, Saudi Arabia
FX The project is funded by the Deanship of Scientific Research
   (IFP-2020-46), Majmaah University, Al-Majmaah, Saudi Arabia.
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NR 167
TC 96
Z9 112
U1 2
U2 34
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD JUL
PY 2021
VL 139
AR 111557
DI 10.1016/j.biopha.2021.111557
EA MAY 2021
PG 15
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA SV2UY
UT WOS:000663680800004
PM 34243621
OA gold
DA 2025-06-11
ER

PT J
AU Serafica, R
   Angosta, AD
AF Serafica, Reimund
   Angosta, Alona D.
TI Acculturation and changes in body mass index, waist circumference, and
   waist-hip ratio among Filipino Americans with hypertension
SO JOURNAL OF THE AMERICAN SOCIETY OF HYPERTENSION
LA English
DT Article
DE Bicultural; blood pressure; immigrants; weight gain
ID CARDIOVASCULAR-DISEASE; BLOOD-PRESSURE; METABOLIC SYNDROME;
   PHYSICAL-ACTIVITY; RISK-FACTORS; WOMEN; PREVALENCE; IMMIGRANTS; OBESITY;
   US
AB The purpose of this research study was to examine whether level of acculturation is a predictor of body mass index, waist circumference, and waist-hip ratio in Filipino Americans with hypertension in the United States. The Filipino Americans (N = 108) were recruited from a primary care clinic in the United States. Two instruments were used to collect and operationalize the variables, specifically: (1) Socioeconomic/Demographic Questionnaire and (2) A Short Acculturation Scale for Filipino Americans. Descriptive statistics and partial least squares were used to calculate the results. The partial least square path model identified acculturation as a predictor of body mass index, wait circumference, and waist-hip ratio among Filipino Americans. The positive path coefficient (beta = 0.384) was statistically significant (t = 5.92, P < .001). Health care providers need to stress the importance of the degree of acculturation when developing culturally appropriate lifestyle and health promotion interventions among immigrant patients with hypertension. (C) 2016 American Society of Hypertension. All rights reserved.
C1 [Serafica, Reimund; Angosta, Alona D.] Univ Nevada, Sch Nursing, 4505 S Maryland Pkwy,Box 453018, Las Vegas, NV 89154 USA.
C3 Nevada System of Higher Education (NSHE); University of Nevada Las Vegas
RP Serafica, R (corresponding author), Univ Nevada, Sch Nursing, 4505 S Maryland Pkwy,Box 453018, Las Vegas, NV 89154 USA.
EM reimund.serafica@unlv.edu
RI Serafica, Reimund/Q-5439-2019; Angosta, Alona/O-8530-2015
OI D. Angosta, Alona/0000-0001-8796-3245; Serafica,
   Reimund/0000-0001-6875-5168
FU University of Nevada, Las Vegas School of Nursing Intramural Research
   Grant Award
FX This project was funded by the University of Nevada, Las Vegas School of
   Nursing Intramural Research Grant Award.
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NR 27
TC 13
Z9 14
U1 1
U2 9
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1933-1711
EI 1878-7436
J9 J AM SOC HYPERTENS
JI J. Am. Soc. Hypertens.
PD SEP
PY 2016
VL 10
IS 9
BP 733
EP 740
DI 10.1016/j.jash.2016.07.002
PG 8
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Cardiovascular System & Cardiology
GA DW8RI
UT WOS:000383922800010
PM 27515181
DA 2025-06-11
ER

PT J
AU Ruiz-Ramírez, A
   López-Acosta, O
   Barrios-Maya, MA
   El-Hafidi, M
AF Ruiz-Ramirez, Angelica
   Lopez-Acosta, Ocarol
   Angel Barrios-Maya, Miguel
   El-Hafidi, Mohammed
TI Cell Death and Heart Failure in Obesity: Role of Uncoupling Proteins
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Review
ID FATTY-ACID OXIDATION; OXYGEN SPECIES PRODUCTION; ACTIVATED
   RECEPTOR-ALPHA; ACYL-COA DEHYDROGENASE; CYTOCHROME-C RELEASE;
   PRESSURE-OVERLOAD; CARDIAC-HYPERTROPHY; SKELETAL-MUSCLE; MITOCHONDRIA;
   APOPTOSIS
AB Metabolic diseases such as obesity, metabolic syndrome, and type II diabetes are often characterized by increased reactive oxygen species (ROS) generation in mitochondrial respiratory complexes, associated with fat accumulation in cardiomyocytes, skeletal muscle, and hepatocytes. Several rodents studies showed that lipid accumulation in cardiac myocytes produces lipotoxicity that causes apoptosis and leads to heart failure, a dynamic pathological process. Meanwhile, several tissues including cardiac tissue develop an adaptive mechanism against oxidative stress and lipotoxicity by overexpressing uncoupling proteins (UCPs), specific mitochondrial membrane proteins. In heart from rodent and human with obesity, UCP2 and UCP3 may protect cardiomyocytes from death and from a state progressing to heart failure by downregulating programmed cell death. UCP activation may affect cytochrome c and proapoptotic protein release from mitochondria by reducing ROS generation and apoptotic cell death. Therefore the aim of this review is to discuss recent findings regarding the role that UCPs play in cardiomyocyte survival by protecting against ROS generation and maintaining bioenergetic metabolism homeostasis to promote heart protection.
C1 [Ruiz-Ramirez, Angelica; Lopez-Acosta, Ocarol; Angel Barrios-Maya, Miguel; El-Hafidi, Mohammed] Inst Nacl Cardiol Ignacio Chavez, Dept Biomed Cardiovasc, Juan Badiano 1, Mexico City 14080, DF, Mexico.
C3 National Institute of Cardiology - Mexico
RP El-Hafidi, M (corresponding author), Inst Nacl Cardiol Ignacio Chavez, Dept Biomed Cardiovasc, Juan Badiano 1, Mexico City 14080, DF, Mexico.
EM medelhafidi@yahoo.com
RI El-Hafidi, Mohammed/AAN-4083-2021
FU CONACyT [106845]; Instituto de Ciencia y Tecnologia del Distrito
   Federal, Mexico City (ICyTDF) [PICDS08-67]
FX This work was supported in part by CONACyT: Grant no. 106845, and by
   Instituto de Ciencia y Tecnologia del Distrito Federal, Mexico City
   (ICyTDF): Grant no. PICDS08-67.
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NR 113
TC 42
Z9 45
U1 1
U2 11
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PY 2016
VL 2016
AR 9340654
DI 10.1155/2016/9340654
PG 11
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA DV0WD
UT WOS:000382640400001
PM 27642497
OA hybrid, Green Submitted, Green Published, Green Accepted
DA 2025-06-11
ER

PT J
AU Mucci, L
   Santilli, F
   Cuccurullo, C
   Davì, G
AF Mucci, Luciana
   Santilli, Francesca
   Cuccurullo, Chiara
   Davi, Giovanni
TI Cardiovascular risk and dietary sugar intake: is the link so sweet?
SO INTERNAL AND EMERGENCY MEDICINE
LA English
DT Review
DE Sugar sweetened beverages; Diabetes; Obesity; Cardiovascular risk
ID TYPE-2 DIABETES-MELLITUS; SOFT DRINK CONSUMPTION; INDUCED WEIGHT-LOSS;
   MIDDLE-AGED WOMEN; BEVERAGE CONSUMPTION; PLATELET ACTIVATION; METABOLIC
   SYNDROME; INSULIN SENSITIVITY; DISEASE RISK; OBESE WOMEN
AB Soft drinks and sugar-sweetened beverages have been targeted as one of the primary culprits in the escalating rates of obesity and diabetes and reduction of added sugars is considered between the goals to achieve in order to promote cardiovascular health and to reduce deaths from cardiovascular causes. Many reliable mechanisms, such as dislypidemia, inflammation and enhanced oxidative stress, have been proposed to support a causal link between sugar sweetened beverages intake and cardiovascular risk, but the ultimate underlying pathways remain to be determined in adequately designed studies. Furthermore, while epidemiological evidence strongly supports an association between sugar sweetened beverages consumption and obesity, type 2 diabetes mellitus or cardiovascular risk, incongruous findings yielded by clinical trials, or formal meta-analyses make difficult to draw firm conclusions in this regard. Further and rigorous studies are needed to better understand the role of sugar sweetened beverages in the etiology of cardiovascular diseases and to better address the warnings and decisions of regulatory authorities on public health worldwide.
C1 [Santilli, Francesca; Davi, Giovanni] Univ G dAnnunzio, Ctr Excellence Aging, Chieti, Italy.
   [Mucci, Luciana] Univ Cattolica Sacro Cuore, Sch Med, Dept Pharmacol, Rome, Italy.
   [Cuccurullo, Chiara] Univ Molise, Dept Hlth Sci, Campobasso, Italy.
C3 G d'Annunzio University of Chieti-Pescara; Catholic University of the
   Sacred Heart; IRCCS Policlinico Gemelli; University of Molise
RP Davì, G (corresponding author), Univ G dAnnunzio, Ctr Excellence Aging, Chieti, Italy.
EM gdavi@unich.it
RI Santilli, Francesca/ABC-6243-2021; Davi, Giovanni/K-7659-2016
OI Davi, Giovanni/0000-0002-3044-0870; Santilli,
   Francesca/0000-0002-4593-905X
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NR 50
TC 17
Z9 17
U1 1
U2 23
PU SPRINGER-VERLAG ITALIA SRL
PI MILAN
PA VIA DECEMBRIO, 28, MILAN, 20137, ITALY
SN 1828-0447
J9 INTERN EMERG MED
JI Intern. Emerg. Med.
PD AUG
PY 2012
VL 7
IS 4
BP 313
EP 322
DI 10.1007/s11739-011-0606-7
PG 10
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 980ZF
UT WOS:000306932000006
PM 21544534
DA 2025-06-11
ER

PT J
AU Okazaki, Y
   Kakehi, S
   Xu, YH
   Tsujimo, K
   Sasaki, M
   Ogawa, H
   Kato, N
AF Okazaki, Yukako
   Kakehi, Shoko
   Xu, Yonghui
   Tsujimo, Kazuhisa
   Sasaki, Masahiro
   Ogawa, Hiroshi
   Kato, Norihisa
TI Consumption of Sericin Reduces Serum Lipids, Ameliorates Glucose
   Tolerance and Elevates Serum Adiponectin in Rats Fed a High-Fat Diet
SO BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
LA English
DT Article
DE sericin; serum lipid; adiponectin; glucose tolerance; rat
ID OXIDATIVE STRESS; SILK PROTEIN; METABOLIC SYNDROME; OBESITY;
   TUMORIGENESIS; HEALTH; MOUSE; ACID; MICE; SKIN
AB The effect was examined of dietary sericin on the lipid and carbohydrate metabolism in rats fed with a high-fat diet. The rats were fed with a 20% beef tallow diet with or without sericin at the level of 4% for 5 weeks. The final body weight and white adipose tissue weight were unaffected by dietary manipulation. The consumption of sericin significantly reduced the serum levels of triglyceride, cholesterol, phospholipids and free fatty acids. Serum very-low-density lipoprotein (VLDL)-triglyceride, VLDL-cholesterol, low-density lipoprotein (LDL)-cholesterol and LDL-phospholipids were also significantly reduced by the sericin intake. Liver triglyceride and the activities of glucose 6-phosphate dehydrogenase and malic enzyme, the lipogenic enzymes, were also reduced by the sericin intake. Dietary sericin caused a marked elevation in serum adiponectin. The consumption of sericin suppressed the increases in plasma glucose and insulin levels after an intraperitoneal glucose injection. These results imply the usefulness of sericin for improving the lipid and carbohydrate metabolism in rats fed on a high-fat diet.
C1 [Okazaki, Yukako] Fuji Womens Univ, Fac Human Life Sci, Ishikari, Hokkaido 0613204, Japan.
   [Kakehi, Shoko; Xu, Yonghui; Kato, Norihisa] Hiroshima Univ, Grad Sch Biosphere Sci, Higashihiroshima 7398528, Japan.
   [Tsujimo, Kazuhisa; Sasaki, Masahiro] Seiren Co Ltd, Fukui 9188560, Japan.
   [Ogawa, Hiroshi] Tezukayamagakuin Univ, Osaka 5900113, Japan.
C3 Hiroshima University
RP Okazaki, Y (corresponding author), Fuji Womens Univ, Fac Human Life Sci, Ishikari, Hokkaido 0613204, Japan.
EM yokazaki@fujijoshi.ac.jp
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NR 28
TC 60
Z9 65
U1 6
U2 16
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 0916-8451
EI 1347-6947
J9 BIOSCI BIOTECH BIOCH
JI Biosci. Biotechnol. Biochem.
PD AUG
PY 2010
VL 74
IS 8
BP 1534
EP 1538
DI 10.1271/bbb.100065
PG 5
WC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
   Chemistry, Applied; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
   Chemistry; Food Science & Technology
GA 648VJ
UT WOS:000281722200004
PM 20699593
OA Bronze
DA 2025-06-11
ER

PT J
AU Zsálig, D
   Berta, A
   Tóth, V
   Szabó, Z
   Simon, K
   Figler, M
   Pusztafalvi, H
   Polyák, É
AF Zsalig, Dorottya
   Berta, Aniko
   Toth, Vivien
   Szabo, Zoltan
   Simon, Klara
   Figler, Maria
   Pusztafalvi, Henriette
   Polyak, Eva
TI A Review of the Relationship between Gut Microbiome and Obesity
SO APPLIED SCIENCES-BASEL
LA English
DT Review
DE gut microbiome; obesity; weight loss
ID HIGH-FAT; INTESTINAL PERMEABILITY; METABOLIC SYNDROME; CESAREAN-SECTION;
   DOUBLE-BLIND; DIET; ASSOCIATION; DYSBIOSIS; BIRTH; CONSUMPTION
AB Obesity is a rapidly growing problem of public health on a worldwide scale, responsible for more than 60% of deaths associated with high body mass index. Recent studies underpinned the augmenting importance of the gut microbiota in obesity. Gut microbiota alterations affect the energy balance of the host organism; namely, as a factor affecting energy production from the diet and as a factor affecting host genes regulating energy expenditure and storage. Gut microbiota composition is characterised by constant variability, and is affected by several dietary factors, suggesting the probability that manipulation of the gut microbiota may promote leaning or prevent obesity. Our narrative review summarizes the results of recent years that stress the effect of gut microbiota in the development of obesity. It investigates the factors (diet, dietary components, lifestyle, and environment) that might affect the gut microbiota composition. Possible strategies for the prevention and/or treatment of obesity include restoring or modifying the composition of the microbiota by consuming prebiotics and probiotics, fermented foods, fruits, vegetables, and avoiding foods of animal origin high in saturated fat and sugar.
C1 [Zsalig, Dorottya; Simon, Klara] Univ Pecs, Fac Hlth Sci, Doctoral Sch Hlth Sci, H-7621 Pecs, Hungary.
   [Berta, Aniko] Univ Pecs, Med Sch, Dept Languages Biomed Purposes & Commun, H-7624 Pecs, Hungary.
   [Toth, Vivien] Univ Pecs, Inst Biol, Dept Gen & Environm Microbiol, H-7604 Pecs, Hungary.
   [Toth, Vivien; Szabo, Zoltan; Figler, Maria; Polyak, Eva] Univ Pecs, Fac Hlth Sci, Inst Nutr Sci & Dietet, H-7621 Pecs, Hungary.
   [Figler, Maria] Univ Pecs, Clin Ctr, Dept Internal Med 2, H-7624 Pecs, Hungary.
   [Figler, Maria] Univ Pecs, Nephrol Ctr, H-7624 Pecs, Hungary.
   [Pusztafalvi, Henriette] Univ Pecs, Fac Hlth Sci, Inst Hlth Insurance, Dept Hlth Promot & Publ Hlth, H-7621 Pecs, Hungary.
C3 University of Pecs; University of Pecs; University of Pecs; University
   of Pecs; University of Pecs; University of Pecs; University of Pecs
RP Zsálig, D (corresponding author), Univ Pecs, Fac Hlth Sci, Doctoral Sch Hlth Sci, H-7621 Pecs, Hungary.
EM dorottya.zsalig@etk.pte.hu
RI Szabó, Zoltán/IZQ-3233-2023
OI Polyak, Eva/0000-0002-3648-1614
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NR 116
TC 41
Z9 42
U1 3
U2 43
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3417
J9 APPL SCI-BASEL
JI Appl. Sci.-Basel
PD JAN
PY 2023
VL 13
IS 1
AR 610
DI 10.3390/app13010610
PG 16
WC Chemistry, Multidisciplinary; Engineering, Multidisciplinary; Materials
   Science, Multidisciplinary; Physics, Applied
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Engineering; Materials Science; Physics
GA 7P5XM
UT WOS:000908778100001
OA gold
DA 2025-06-11
ER

PT J
AU Burger, RJ
   Delagrange, H
   van Valkengoed, IGM
   de Groot, CJM
   van den Born, BJH
   Gordijn, SJ
   Ganzevoort, W
AF Burger, Renee J.
   Delagrange, Hannelore
   van Valkengoed, Irene G. M.
   de Groot, Christianne J. M.
   van den Born, Bert-Jan H.
   Gordijn, Sanne J.
   Ganzevoort, Wessel
TI Hypertensive Disorders of Pregnancy and Cardiovascular Disease Risk
   Across Races and Ethnicities: A Review
SO FRONTIERS IN CARDIOVASCULAR MEDICINE
LA English
DT Review
DE hypertensive disorders of pregnancy; preeclampsia; cardiovascular
   disease; hypertension; diabetes; ethnicity; chronic kidney disease;
   dyslipidemia
ID TERTIARY CARE CENTER; BODY-MASS INDEX; PERSISTENT HYPERTENSION; MATERNAL
   HYPERTENSION; RACIAL DISPARITIES; METABOLIC SYNDROME; DIABETES-MELLITUS;
   AFRICAN-AMERICAN; FOLLOW-UP; SUBSEQUENT HYPERTENSION
AB Pregnancy is often considered to be a "cardiometabolic stress-test" and pregnancy complications including hypertensive disorders of pregnancy can be the first indicator of increased risk of future cardiovascular disease. Over the last two decades, more evidence on the association between hypertensive disorders of pregnancy and cardiovascular disease has become available. However, despite the importance of addressing existing racial and ethnic differences in the incidence of cardiovascular disease, most research on the role of hypertensive disorders of pregnancy is conducted in white majority populations. The fragmented knowledge prohibits evidence-based targeted prevention and intervention strategies in multi-ethnic populations and maintains the gap in health outcomes. In this review, we present an overview of the evidence on racial and ethnic differences in the occurrence of hypertensive disorders of pregnancy, as well as evidence on the association of hypertensive disorders of pregnancy with cardiovascular risk factors and cardiovascular disease across different non-White populations, aiming to advance equity in medicine.
C1 [Burger, Renee J.; Ganzevoort, Wessel] Amsterdam UMC Locat Univ Amsterdam, Dept Obstet & Gynaecol, Amsterdam, Netherlands.
   [Burger, Renee J.; de Groot, Christianne J. M.; Ganzevoort, Wessel] Amsterdam Reprod & Dev Pregnancy & Birth, Amsterdam, Netherlands.
   [Delagrange, Hannelore; Gordijn, Sanne J.] Univ Groningen, Univ Med Ctr Groningen, Dept Obstet, Groningen, Netherlands.
   [van Valkengoed, Irene G. M.] Amsterdam UMC Locat Univ Amsterdam, Dept Publ & Occupat Hlth, Amsterdam, Netherlands.
   [van Valkengoed, Irene G. M.] Amsterdam Publ Hlth Hlth Behav & Chron Dis, Amsterdam, Netherlands.
   [de Groot, Christianne J. M.] Amsterdam UMC Locat Vrije Univ Amsterdam, Dept Obstet & Gynaecol, Amsterdam, Netherlands.
   [van den Born, Bert-Jan H.] Amsterdam UMC Locat Univ Amsterdam, Dept Vasc Med, Amsterdam, Netherlands.
   [van den Born, Bert-Jan H.] Amsterdam Cardiovasc Sci Atherosclerosis & Ischem, Amsterdam, Netherlands.
C3 University of Groningen
RP Burger, RJ (corresponding author), Amsterdam UMC Locat Univ Amsterdam, Dept Obstet & Gynaecol, Amsterdam, Netherlands.; Burger, RJ (corresponding author), Amsterdam Reprod & Dev Pregnancy & Birth, Amsterdam, Netherlands.
EM r.j.burger@amsterdamumc.nl
RI van den Born, Bert-Jan/IUQ-0970-2023; Gordijn, Sanne/ACV-2652-2022; van
   Valkengoed, Irene/ABA-1551-2021; Ganzevoort, Wessel/AAH-4468-2020
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NR 139
TC 19
Z9 21
U1 0
U2 8
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2297-055X
J9 FRONT CARDIOVASC MED
JI Front. Cardiovasc. Med.
PD JUN 28
PY 2022
VL 9
AR 933822
DI 10.3389/fcvm.2022.933822
PG 15
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 3H3TY
UT WOS:000831962400001
PM 35837605
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Mahalaxmi, G
   Ashok, S
   Arun, G
   Srinivas, G
AF Mahalaxmi, Ganjoo
   Ashok, Sivasailam
   Arun, Gangadharan
   Srinivas, Gopala
TI Albumin binds to uncoupler CCCP to diminish depolarization of
   mitochondria
SO TOXICOLOGY IN VITRO
LA English
DT Article
DE CCCP; Albumin; BSA; Serum; Mitochondrial depolarization
AB Mitochondria are at the core of cellular energy metabolism and are also involved in the oxidative stress response and programmed cell death pathways. Mitochondrial dysfunction is found to be associated with many disease conditions like metabolic syndrome, neurodegenerative disorders, coronary artery diseases, cancer, etc. This has generated considerable interest in the scientific community over the assessment of mitochondrial function and mitochondrial damage. One of the most common methodologies in these studies is by analysing the mitochondrial activity in the presence of mitochondrial substrates, inhibitors and uncouplers. Apart from the specific effects of these molecules on mitochondria, their interactions with the components of the experimental system could interfere with the results derived. Therefore, the role some specific experimental conditions would have on the outcome should be carefully elucidated. Fetal Bovine Serum or Bovine Serum Albumin (BSA); routinely used in in vitro experiments for their growth promoting and surfactant properties; can have profound impact on the pharmacokinetics of chemical compounds as albumin residue can bind to and affect their bioavailability. In the present study, we demonstrate that Carbonyl cyanide 3-chlorophenylhydrazone (CCCP) induced mitochondrial depolarization is hindered in the presence of albumin due to the molecular interaction between CCCP and albumin.
C1 [Mahalaxmi, Ganjoo; Ashok, Sivasailam; Srinivas, Gopala] Sree Chitra Tirunal Inst Med Sci & Technol, Dept Biochem, Trivandrum 695011, Kerala, India.
   [Arun, Gangadharan] Kannur Univ, Dept Biotechnol & Microbiol, Kannur, Kerala, India.
C3 Department of Science & Technology (India); Sree Chitra Tirunal
   Institute for Medical Sciences Technology (SCTIMST)
RP Srinivas, G (corresponding author), Sree Chitra Tirunal Inst Med Sci & Technol, Dept Biochem, Trivandrum 695011, Kerala, India.
EM srinivasg@sctimst.ac.in
RI Govindarajulu, Srinivas/ABF-4608-2020
OI Sivasailam, Ashok/0000-0001-8536-4206; Gopala,
   Srinivas/0000-0001-5885-6256
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NR 17
TC 9
Z9 9
U1 2
U2 10
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0887-2333
EI 1879-3177
J9 TOXICOL IN VITRO
JI Toxicol. Vitro
PD APR
PY 2022
VL 80
AR 105325
DI 10.1016/j.tiv.2022.105325
EA FEB 2022
PG 7
WC Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Toxicology
GA 0E5JA
UT WOS:000776716500002
PM 35121064
DA 2025-06-11
ER

PT J
AU Khalil, M
   Hayek, S
   Khalil, N
   Serale, N
   Vergani, L
   Calasso, M
   De Angelis, M
   Portincasa, P
AF Khalil, Mohamad
   Hayek, Soukayna
   Khalil, Nour
   Serale, Nadia
   Vergani, Laura
   Calasso, Maria
   De Angelis, Maria
   Portincasa, Piero
TI Role of Sumac (Rhus coriaria L.) in the management of metabolic syndrome
   and related disorders: Focus on NAFLD-atherosclerosis interplay
SO JOURNAL OF FUNCTIONAL FOODS
LA English
DT Article
DE Rhus coriaria L; (sumac); Functional foods; Metabolic diseases;
   Medicinal plants; Atherosclerosis
ID FATTY LIVER-DISEASE; INTIMA-MEDIA THICKNESS; DIET-INDUCED OBESITY;
   BODY-MASS INDEX; INSULIN-RESISTANCE; METHYL GALLATE; BLOOD-PRESSURE;
   GLUCOSE-TOLERANCE; EXTRACT; ACID
AB Sumac (Rhus coriaria L.) is a commonly used spice in the Mediterranean region and considered as healthy food ingredients. The beneficial value of sumac is well documented in folk medicine. Accumulating data explored the phytochemical, nutritional and therapeutic proprieties suggesting sumac as a potential functional food. Here, we discuss the general and scientific aspects of sumac. Sumac is rich in different polyphenolic compounds such as flavonoids, tannins, and phenolic acids. The potential therapeutic effects of sumac have been studied in various cellular and animal models, as well as in human. These reports suggest that Sumac has potential effect against oxidative stress, inflammation, obesity, hyperglycemia, hypercholesterolemia, and hyperlipidemia, which represent key pathogenic mechanisms contributing to cardio-metabolic, liver, and cancer diseases. Clinical studies using sumac or its major compounds, suggest that this herbal product may represent a useful therapeutic tool in the management of metabolic-related conditions such as liver-atherosclerosis complications.
C1 [Khalil, Mohamad; Portincasa, Piero] Univ Bari, Med Sch, Dept Biomed Sci & Human Oncol, Clin Med A Murri, Piazza Giulio Cesare 11, I-70124 Bari, Italy.
   [Khalil, Mohamad; Serale, Nadia; Calasso, Maria; De Angelis, Maria] Univ Bari Aldo Moro, Dept Soil Plant & Food Sci, Via Amendola 165-a, I-70126 Bari, Italy.
   [Hayek, Soukayna] Notre Dame Univ, Fac Nat & Appl Sci, Louaize, Lebanon.
   [Hayek, Soukayna] Lebanese Univ, Fac Agr Sci, Dekwaneh, Lebanon.
   [Khalil, Nour] Al Jinan Univ, Fac Publ Hlth, Saida, Lebanon.
   [Vergani, Laura] Univ Genoa, Dept Earth Environm & Life Sci DISTAV, Corso Europa 26, I-16132 Genoa, Italy.
C3 Universita degli Studi di Bari Aldo Moro; Universita degli Studi di Bari
   Aldo Moro; Notre Dame University Lebanon; University of Genoa
RP Portincasa, P (corresponding author), Univ Bari, Med Sch, Dept Biomed Sci & Human Oncol, Clin Med A Murri, Piazza Giulio Cesare 11, I-70124 Bari, Italy.
EM piero.portincasa@uniba.it
RI De Angelis, Maria/AAA-9909-2019; Khalil, Mohamad/ISA-5550-2023; Vergani,
   Laura/AAS-2711-2020; portincasa, piero/J-7245-2018; Serale,
   Nadia/KLY-5058-2024
OI Serale, Nadia/0000-0002-5552-9361; De Angelis,
   Maria/0000-0002-2010-884X; KHALIL, MOHAMAD/0000-0002-5943-9531; Hayek,
   Soukayna/0000-0002-4762-6284
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NR 152
TC 18
Z9 18
U1 1
U2 17
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1756-4646
EI 2214-9414
J9 J FUNCT FOODS
JI J. Funct. Food.
PD DEC
PY 2021
VL 87
AR 104811
DI 10.1016/j.jff.2021.104811
EA OCT 2021
PG 16
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA WN2ZH
UT WOS:000711641500004
OA gold
DA 2025-06-11
ER

PT J
AU Lorenzo, PI
   Cobo-Vuilleumier, N
   Gauthier, BR
AF Lorenzo, Petra I.
   Cobo-Vuilleumier, Nadia
   Gauthier, Benoit R.
TI Therapeutic potential of pancreatic PAX4-regulated pathways in treating
   diabetes mellitus
SO CURRENT OPINION IN PHARMACOLOGY
LA English
DT Article
ID FATTY-ACID-COMPOSITION; BETA-CELLS; MICROBUBBLE DESTRUCTION; METABOLIC
   SYNDROME; GALECTIN-9; PROMOTES; ALPHA; PAX4; OVEREXPRESSION; INHIBITORS
AB The high prevalence of diabetes mellitus (DM) in our society, together with the fact that current treatments are only palliative and do not prevent the development of life threatening side effects, highlights the urgent need for novel therapies targeting the root cause of the disease. Independent of the etiology of DM, the definitive therapeutic approach will imply the restitution of an adequate functional beta-cell mass capable of compensating for the insulin demand of the organism. The recent demonstration of heterogeneity within the islets as well as their innate plasticity has encouraged the development of studies aiming at potentiation of the regenerative capacity of islets. In this regard, factors implicated in pancreas ontogeny as well as in the adaptation processes that take place in the islets under situations of increased insulin demand have gained much interest. One of these factors is the transcription factor PAX4, required for beta-cell formation during embryonic development and implicated in adult beta-cell adaptation under stress situations. Here we review the therapeutic potential of PAX4 as well as its downstream targets for the development of novel treatments for DM.
C1 [Lorenzo, Petra I.; Cobo-Vuilleumier, Nadia; Gauthier, Benoit R.] Univ Seville, Univ Pablo de Olavide, Andalusian Ctr Mol Biol & Regenerat Med, CSIC,CABIMER,Junta Andalucia, Seville 41092, Spain.
C3 Consejo Superior de Investigaciones Cientificas (CSIC); Universidad
   Pablo de Olavide; University of Sevilla; CSIC - Centro Andaluz de
   Biologia Molecular y Medicina Regenerativa (CABIMER)
RP Gauthier, BR (corresponding author), Univ Seville, Univ Pablo de Olavide, Andalusian Ctr Mol Biol & Regenerat Med, CSIC,CABIMER,Junta Andalucia, Seville 41092, Spain.
EM benoit.gauthier@cabimer.es
RI Lorenzo, Petra I/H-8962-2017; Gauthier, Benoit/C-3138-2017
OI Gauthier, Benoit/0000-0001-8146-7486; Lorenzo, Petra
   I./0000-0002-3926-6514
FU Consejeria de Salud, Fundacion Ptiblica Andaluza Progreso v Salud, junta
   de Andalucia [PI-0727-2010, P1-0085-2013]; Consejeria de Economia,
   Innovacion y Ciencia [P10.CTS.6359]; Ministerio de Economia y
   Competidividad, Institute de Salud Carlos III - Fondos FEDER
   [PI10/00871, PI13/00593]
FX The authors thank past and present members of the laboratory for
   discussions related to PAX4. Authors are supported by grants from the
   Consejeria de Salud, Fundacion Ptiblica Andaluza Progreso v Salud, junta
   de Andalucia (PI-0727-2010 to BRG and P1-0085-2013 to PIL), Consejeria
   de Economia, Innovacion y Ciencia (P10.CTS.6359 to BRG) and the
   Ministerio de Economia y Competidividad, Institute de Salud Carlos III
   co-funded by Fondos FEDER (PI10/00871 and PI13/00593 to BRG).
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NR 63
TC 13
Z9 14
U1 0
U2 5
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1471-4892
EI 1471-4973
J9 CURR OPIN PHARMACOL
JI Curr. Opin. Pharmacol.
PD DEC
PY 2018
VL 43
BP 1
EP 10
DI 10.1016/j.coph.2018.07.004
PG 10
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA HG6CD
UT WOS:000455067700003
PM 30048825
DA 2025-06-11
ER

PT J
AU Ma, ZH
   Liu, HY
   Wang, WJ
   Guan, SJ
   Yi, JF
   Chu, L
AF Ma, Zhihong
   Liu, Hongying
   Wang, Weijie
   Guan, Shengjiang
   Yi, Jianfeng
   Chu, Li
TI Paeoniflorin suppresses lipid accumulation and alleviates insulin
   resistance by regulating the Rho kinase/IRS-1 pathway in
   palmitate-induced HepG2Cells
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Article
DE Paeoniflorin; Lipid accumulation; Insulin resistance; Rho kinase
ID FATTY LIVER-DISEASE; KAPPA-B PATHWAY; METABOLIC SYNDROME; NONALCOHOLIC
   STEATOHEPATITIS; OXIDATIVE STRESS; SKELETAL-MUSCLE; RATS; HEPATOCYTES;
   STEATOSIS; MICE
AB In this study, we evaluated the effects of paeoniflorin (PF) on palmitate (PA)-induced insulin resistance and explored the potential molecular mechanisms in HepG2 cells. HepG2 cells were pre-treated with 3 mu M, 30 mu M, or 100 mu M PF for 1 h followed by immediate stimulation with 0.25 mM palmitate for 24 h to induce hepatic steatosis. PF treatment could decrease PA-induced intracellular lipid deposition via inhibiting de novo lipid synthesis. PF treatment also restored insulin sensitivity by suppressing the activation of Rho kinase (ROCK) and the expression of serine phosphorylation of insulin receptor substrate (IRS)-1, thereby promoting Akt and glycogen synthase kinase (GSK)-3 beta phosphorylation. These results suggest that PF alleviates PA-induced hepatic steatosis and insulin resistance in HepG2 cells. Furthermore, the effect of PF may be associated with its role in inhibiting de novo lipid synthesis and in regulating the ROCK/IRS/Akt signalling pathways. (C) 2017 Elsevier Masson SAS. All rights reserved.
C1 [Ma, Zhihong; Yi, Jianfeng] Yichun Univ, Key Lab Res Act Ingredients Nat Med Jiangxi Prov, Yichun 336000, Peoples R China.
   [Ma, Zhihong] Hebei Univ Chinese Med, Dept Immunol & Pathobiol, Shijiazhuang 050200, Peoples R China.
   [Liu, Hongying] Hebei Gen Hosp, Dept Infect Dis, Shijiazhuang 050051, Peoples R China.
   [Wang, Weijie] Hebei Med Univ, Dept Surg, Hosp 2, Shijiazhuang 050000, Peoples R China.
   [Guan, Shengjiang] Hebei Univ Chinese Med, Dept Pharmacol, Shijiazhuang 050200, Peoples R China.
   [Chu, Li] Hebei Univ Chinese Med, Dept Pharmaceut, Shijiazhuang 050200, Peoples R China.
C3 Yichun University; Hebei University of Chinese Medicine; Hebei Medical
   University; Hebei University of Chinese Medicine; Hebei University of
   Chinese Medicine
RP Yi, JF (corresponding author), Yichun Univ, Key Lab Res Act Ingredients Nat Med Jiangxi Prov, Yichun 336000, Peoples R China.; Chu, L (corresponding author), Hebei Univ Chinese Med, Dept Pharmaceut, Shijiazhuang 050200, Peoples R China.
EM ycxyyjf@163.com; chuli0614@126.com
FU Postdoctoral Science Fundation of Jiangxi Province, China [2014KY49];
   Natural Science Fundation of Hebei Province, China [H2014206285];
   Research Fundation of Health and Family Planning Commission of Hebei
   Province, China [20130144]
FX This study was supported by grants from the Postdoctoral Science
   Fundation of Jiangxi Province (No. 2014KY49), China; the Natural Science
   Fundation of Hebei Province (No. H2014206285), China; and the Research
   Fundation of Health and Family Planning Commission of Hebei Province
   (No. 20130144), China. The authors thank American Journal Experts for
   linguistic support.
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NR 34
TC 25
Z9 25
U1 4
U2 54
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI PARIS
PA 23 RUE LINOIS, 75724 PARIS, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD JUN
PY 2017
VL 90
BP 361
EP 367
DI 10.1016/j.biopha.2017.03.087
PG 7
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA EW4KS
UT WOS:000402471000046
PM 28380411
DA 2025-06-11
ER

PT J
AU Sims-Robinson, C
   Bakeman, A
   Bruno, E
   Jackson, S
   Glasser, R
   Murphy, GG
   Feldman, EL
AF Sims-Robinson, Catrina
   Bakeman, Anna
   Bruno, Elizabeth
   Jackson, Samuel
   Glasser, Rebecca
   Murphy, Geoffrey G.
   Feldman, Eva L.
TI Dietary Reversal Ameliorates Short- and Long-Term Memory Deficits
   Induced by High-fat Diet Early in Life
SO PLOS ONE
LA English
DT Article
ID ENDOPLASMIC-RETICULUM STRESS; INSULIN-RECEPTOR SUBSTRATE-1; BRAIN
   GLUCOSE-METABOLISM; REMOTE SPATIAL MEMORY; INDUCED OBESITY; SERINE
   PHOSPHORYLATION; HIPPOCAMPAL MORPHOLOGY; TAU PHOSPHORYLATION;
   ALZHEIMER-DISEASE; ZUCKER RATS
AB A high-fat diet (HFD), one of the major factors contributing to metabolic syndrome, which is associated with an increased risk of neurodegenerative diseases, leads to insulin resistance and cognitive impairment. It is not known whether these alterations are improved with dietary intervention. To investigate the long-term impact of a HFD on hippocampal insulin signaling and memory, C57BL6 mice were placed into one of three groups based on the diet: a standard diet (control), a HFD, or a HFD for 16 weeks and then the standard diet for 8 weeks (HF16). HFD-induced impairments in glucose tolerance and hippocampal insulin signaling occurred concurrently with deficits in both short-and long-term memory. Furthermore, these conditions were improved with dietary intervention; however, the HFD-induced decrease in insulin receptor expression in the hippocampus was not altered with dietary intervention. Our results demonstrate that memory deficits due to the consumption of a HFD at an early age are reversible.
C1 [Sims-Robinson, Catrina] Med Univ South Carolina, Dept Neurol, Charleston, SC 29425 USA.
   [Sims-Robinson, Catrina; Bakeman, Anna; Bruno, Elizabeth; Jackson, Samuel; Glasser, Rebecca; Feldman, Eva L.] Univ Michigan, Dept Neurol, Ann Arbor, MI 48109 USA.
   [Murphy, Geoffrey G.] Univ Michigan, Dept Mol & Integrat Physiol, Ann Arbor, MI 48109 USA.
   [Murphy, Geoffrey G.] Univ Michigan, Dept Mol, Ann Arbor, MI 48109 USA.
   [Murphy, Geoffrey G.] Univ Michigan, Behav Neurosci Inst, Ann Arbor, MI 48109 USA.
C3 Medical University of South Carolina; University of Michigan System;
   University of Michigan; University of Michigan System; University of
   Michigan; University of Michigan System; University of Michigan;
   University of Michigan System; University of Michigan
RP Sims-Robinson, C (corresponding author), Med Univ South Carolina, Dept Neurol, Charleston, SC 29425 USA.; Sims-Robinson, C (corresponding author), Univ Michigan, Dept Neurol, Ann Arbor, MI 48109 USA.
EM robinsoc@musc.edu
OI Robinson, Catrina/0000-0003-4776-5839; Bruno,
   Elizabeth/0000-0002-8142-4432; Feldman, Eva/0000-0002-9162-2694
FU National Institute of Health (NINDS) [5K01NS079461]; National Institute
   of Health (NIDDK) [5-R24-DK-082941]; National Institute of Health (NIA
   Training Grant) [T32 AG000114]; National Institute of Health (NINDS
   Neurology Training Grant) [T32 NS007222]; A. Alfred Taubman Medical
   Research Institute; Program for Neurology Research and Discovery;
   National Institute of Diabetes and Digestive and Kidney Diseases
   [P30DK020572] Funding Source: NIH RePORTER; National Institute of
   Neurological Disorders and Stroke [T32NS007222] Funding Source: NIH
   RePORTER; National Institute on Aging [T32AG000114] Funding Source: NIH
   RePORTER
FX This work was supported by the National Institute of Health (NINDS
   5K01NS079461, to C. S-R.; NIDDK 5-R24-DK-082941, to E.F.; NIDDK
   Supplement to 5-R24-DK-082941, to C.S-R.; NIA Training Grant T32
   AG000114, to C. S-R.; NINDS Neurology Training Grant T32 NS007222, to C.
   S-R.), the A. Alfred Taubman Medical Research Institute, and the Program
   for Neurology Research and Discovery. The funders had no role in study
   design, data collection, analysis, decision to publish, or preparation
   of the manuscript.
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NR 72
TC 39
Z9 44
U1 0
U2 9
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD SEP 27
PY 2016
VL 11
IS 9
AR e0163883
DI 10.1371/journal.pone.0163883
PG 16
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Science & Technology - Other Topics
GA DX2AT
UT WOS:000384169900033
PM 27676071
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Park, KH
   Park, WJ
AF Park, Kyoung-Ha
   Park, Woo Jung
TI Endothelial Dysfunction: Clinical Implications in Cardiovascular Disease
   and Therapeutic Approaches
SO JOURNAL OF KOREAN MEDICAL SCIENCE
LA English
DT Article
DE Endothelium; Atherosclerosis; Cardiovascular Disease
ID NITRIC-OXIDE SYNTHASE; ASYMMETRIC DIMETHYLARGININE ADMA;
   CORONARY-ARTERY-DISEASE; CHRONIC HEART-FAILURE; C-REACTIVE PROTEIN;
   OXIDATIVE STRESS; VASOMOTOR FUNCTION; DEPENDENT VASODILATION;
   MYOCARDIAL-INFARCTION; METABOLIC SYNDROME
AB Atherosclerosis is a chronic progressive vascular disease. It starts early in life, has a long asymptomatic phase, and a progression accelerated by various cardiovascular risk factors. The endothelium is an active inner layer of the blood vessel. It generates many factors that regulate vascular tone, the adhesion of circulating blood cells, smooth muscle proliferation, and inflammation, which are the key mechanisms of atherosclerosis and can contribute to the development of cardiovascular events. There is growing evidence that functional impairment of the endothelium is one of the first recognizable signs of development of atherosclerosis and is present long before the occurrence of atherosclerotic cardiovascular disease. Therefore, understanding the endothelium's central role provides not only insights into pathophysiology, but also a possible clinical opportunity to detect early disease, stratify cardiovascular risk, and assess response to treatments. In the present review, we will discuss the clinical implications of endothelial function as well as the therapeutic issues for endothelial dysfunction in cardiovascular disease as primary and secondary endothelial therapy.
C1 [Park, Kyoung-Ha; Park, Woo Jung] Hallym Univ, Med Ctr, Dept Internal Med, Cardiovasc Div, Anyang 431796, South Korea.
C3 Hallym University
RP Park, WJ (corresponding author), Hallym Univ, Med Ctr, Dept Internal Med, Cardiovasc Div, 22 Gwanpyeong Ro 170beon Gil, Anyang 431796, South Korea.
EM cathpark@hallym.or.kr
OI Park, Kyoung-Ha/0000-0002-5935-8715
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NR 121
TC 225
Z9 267
U1 0
U2 17
PU KOREAN ACAD MEDICAL SCIENCES
PI SEOUL
PA 302 75 DONG DU ICHON, DONG YONGSAN KU, SEOUL 140 031, SOUTH KOREA
SN 1011-8934
EI 1598-6357
J9 J KOREAN MED SCI
JI J. Korean Med. Sci.
PD SEP
PY 2015
VL 30
IS 9
BP 1213
EP 1225
DI 10.3346/jkms.2015.30.9.1213
PG 13
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA CV4AR
UT WOS:000364208300002
PM 26339159
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Liu, Y
   Chen, HZ
   Liu, DP
AF Liu Yue
   Chen HouZao
   Liu DePei
TI Mechanistic perspectives of calorie restriction on vascular homeostasis
SO SCIENCE CHINA-LIFE SCIENCES
LA English
DT Review
DE calorie restriction (CR); vascular homeostasis; Sirtuin 1 (SIRT1);
   AMP-activated protein kinase (AMPK); mammalian target of rapamycin
   (mTOR); endothelial nitric oxide synthase (eNOS)
ID ACTIVATED PROTEIN-KINASE; NITRIC-OXIDE SYNTHASE; SMOOTH-MUSCLE-CELLS;
   FATTY-ACID OXIDATION; LIFE-SPAN EXTENSION; E-DEFICIENT MICE; INDUCED
   ENDOTHELIAL DYSFUNCTION; CARDIOVASCULAR RISK-FACTORS; ABDOMINAL
   AORTIC-ANEURYSMS; HUMAN METABOLIC SYNDROME
AB Calorie restriction (CR) is a dietary regime based on low calorie intake. CR without malnutrition extends lifespan in a wide range of organisms from yeast to rodents, and CR can prevent and delay the onset of age-related functional decline and diseases in human and non-human primates. CR is a safe and effective intervention to reduce vascular risk factors in humans. In recent years, studies in rodents have provided mechanistic insights into the beneficial effects of CR on vascular homeostasis, including reduced oxidative stress, enhanced nitric oxide (NO) bioactivity, and decreased inflammation. A number of important molecules, including sirtuins, AMP-activated protein kinase, mammalian targets of rapamycin, endothelial nitric oxidase and their regulatory pathways are involved in the maintenance of vascular homeostasis. Evidence has shown that these pathways are responsible for many aspects of CR's effects, and that they may also mediate the effects of CR on vasculature.
C1 [Liu Yue; Chen HouZao; Liu DePei] Chinese Acad Med Sci, Inst Basic Med Sci, Dept Biochem & Mol Biol, State Key Lab Med Mol Biol, Beijing 100005, Peoples R China.
   [Liu Yue; Chen HouZao; Liu DePei] Peking Union Med Coll, Beijing 100005, Peoples R China.
C3 Institute of Basic Medical Sciences - CAMS; Chinese Academy of Medical
   Sciences - Peking Union Medical College; Chinese Academy of Medical
   Sciences - Peking Union Medical College; Peking Union Medical College
RP Chen, HZ (corresponding author), Chinese Acad Med Sci, Inst Basic Med Sci, Dept Biochem & Mol Biol, State Key Lab Med Mol Biol, Beijing 100005, Peoples R China.
EM houzao@gmail.com; liudp@pumc.edu.cn
OI LIU, Yue/0000-0002-7136-1298
FU National Natural Science Foundation of China [31271227, 91339201];
   Beijing Nova Program [XX2013064]; National Basic Research Program of
   China [2011CB503902]
FX We thank Zhang Ran and Fu WenYan (State Key Laboratory of Medical
   Molecular Biology, Department of Biochemistry and Molecular Biology,
   Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences
   & Peking Union Medical College) for critically reading this manuscript.
   This work was supported by the National Natural Science Foundation of
   China (31271227, 91339201), the Beijing Nova Program (XX2013064), and
   the National Basic Research Program of China (2011CB503902).
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PT J
AU Kanikarla-Marie, P
   Jain, SK
AF Kanikarla-Marie, Preeti
   Jain, Sushil K.
TI L-Cysteine supplementation reduces high-glucose and ketone-induced
   adhesion of monocytes to endothelial cells by inhibiting ROS
SO MOLECULAR AND CELLULAR BIOCHEMISTRY
LA English
DT Article
DE L-Cysteine; High glucose; Acetoacetate; ROS; Adhesion; CVD
ID LIPID-PEROXIDATION; OXIDATIVE STRESS; WHEY-PROTEIN; GLUTATHIONE LEVELS;
   METABOLIC SYNDROME; DIABETES-MELLITUS; HYDROGEN-SULFIDE;
   N-ACETYLCYSTEINE; EXPRESSION; RATS
AB Type 1 diabetic (T1D) patients are hyperglycemic and also show elevated blood levels of ketone bodies, particularly acetoacetate (AA) and beta-hydroxybutyrate (BHB). T1D patients have a greater risk of developing endothelial dysfunction and cardiovascular disease (CVD). Supplementation with cysteine-rich milk proteins has been shown to be beneficial in improving various biomarkers of endothelial dysfunction and CVD. This study examines whether l-cysteine (LC) per se prevents monocyte adhesion to endothelial cells, a critical step in endothelial dysfunction. Human umbilical vein endothelial cells and THP-1 monocytes were pretreated with and without LC (500 mu M) for 2 h and then exposed to ketones (AA or BHB, 0-4 mM) and/or high glucose (HG) (25 mM) for 24 h. This study shows that LC reduces HG and ketone-induced ROS production, ICAM-1 expression, and the adhesion of monocytes to endothelial cells. This study provides a biochemical mechanism by which milk protein supplementation can be beneficial in preventing the excess endothelial dysfunction and CVD seen in diabetic patients.
C1 [Kanikarla-Marie, Preeti; Jain, Sushil K.] Louisiana State Univ, Hlth Sci Ctr, Dept Pediat, Shreveport, LA 71130 USA.
   [Kanikarla-Marie, Preeti; Jain, Sushil K.] Louisiana State Univ, Hlth Sci Ctr, Dept Biochem & Mol Biol, Shreveport, LA 71130 USA.
C3 Louisiana State University System; Louisiana State University Health
   Sciences Center at Shreveport; Louisiana State University System;
   Louisiana State University Health Sciences Center at Shreveport
RP Jain, SK (corresponding author), Louisiana State Univ, Hlth Sci Ctr, Dept Pediat, 1501 Kings Highway,POB 33932, Shreveport, LA 71130 USA.
EM sjain@lsuhsc.edu
OI Jain, Sushil/0000-0002-9574-0436; Kanikarla, Preeti/0000-0002-4913-8575
FU NIDDK; ODS [RO1 DK072433]; Malcolm Feist Chair in Diabetes; Malcolm
   Feist Predoctoral Fellowship; Institute for Cardiovascular Diseases and
   Imaging
FX The authors thank Georgia Morgan for excellent editing. The authors are
   supported by NIDDK and the ODS (RO1 DK072433), the Malcolm Feist Chair
   in Diabetes, and the Malcolm Feist Predoctoral Fellowship by the
   Institute for Cardiovascular Diseases and Imaging.
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NR 54
TC 19
Z9 21
U1 0
U2 11
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0300-8177
EI 1573-4919
J9 MOL CELL BIOCHEM
JI Mol. Cell. Biochem.
PD JUN
PY 2014
VL 391
IS 1-2
BP 251
EP 256
DI 10.1007/s11010-014-2009-3
PG 6
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA AG7AM
UT WOS:000335570400028
PM 24627243
DA 2025-06-11
ER

PT J
AU Wang, Y
   Xu, C
   Liang, Y
   Vanhoutte, PM
AF Wang, Yu
   Xu, Cheng
   Liang, Yan
   Vanhoutte, Paul M.
TI SIRT1 in metabolic syndrome: Where to target matters
SO PHARMACOLOGY & THERAPEUTICS
LA English
DT Review
DE Silent information regulator; Aging; Sirtuin; Metabolic disorders;
   Cardiovascular diseases
ID TRANSCRIPTION FACTOR FOXO1; NAD-DEPENDENT DEACETYLASE; LIFE-SPAN
   EXTENSION; MATING-TYPE LOCUS; SACCHAROMYCES-CEREVISIAE; CALORIE
   RESTRICTION; SKELETAL-MUSCLE; ADIPOSE-TISSUE; OXIDATIVE STRESS;
   FATTY-ACID
AB Sirtuin 1 (SIRT1), the mammalian ortholog of yeast Sir2p, is a highly conserved NAD(+)-dependent protein deacetylase that has emerged as a key cardiometabolic regulator. During the past decade, Sir2p has been the focus of intense investigations and discussion because it regulates longevity in yeast, worms and flies. Although the extrapolation of data obtained from yeast Sir2p to mammalian SIRT1 cannot be automatic, animal studies provide convincing evidence that SIRT1 is a potent protector against aging-associated pathologies, in particular metabolic disorders and cardiovascular diseases. Indeed, many exciting connections exist between the protein deacetylation function of SIRT1 and its role in fundamental biological responses to various nutritional and environmental signals. As a result, pharmaceutical and nutriceutical interventions targeting SIRT1 are promising strategies to combat aging-associated diseases. The present review summarizes the recent progress in SIRT1 research with a particular focus on the specificities of this protein in individual tissues as they relate to cardiometabolic control. (C) 2012 Elsevier Inc. All rights reserved.
C1 [Wang, Yu; Xu, Cheng; Liang, Yan; Vanhoutte, Paul M.] Univ Hong Kong, LKS Fac Med, Dept Pharmacol & Pharm, Pokfulam, Hong Kong, Peoples R China.
C3 University of Hong Kong
RP Wang, Y (corresponding author), LKS Fac, Level 2,Lab Block,Med Bldg,21 Sassoon Rd, Pokfulam, Hong Kong, Peoples R China.
EM yuwanghk@hku.hk; vanhoutt@hku.hk
RI Wang, Yu/B-4534-2009; Vanhoutte, Paul/B-4533-2009
OI wang, yu/0000-0001-8697-2940
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NR 240
TC 45
Z9 49
U1 0
U2 30
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0163-7258
J9 PHARMACOL THERAPEUT
JI Pharmacol. Ther.
PD DEC
PY 2012
VL 136
IS 3
BP 305
EP 318
DI 10.1016/j.pharmthera.2012.08.009
PG 14
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 036JT
UT WOS:000311022900004
PM 22939883
DA 2025-06-11
ER

PT J
AU Pauwels, EKJ
AF Pauwels, Ernest K. J.
TI THE MEDITERRANEAN DIET, PART III: COMPOUNDS, COMPONENTS AND
   CONSIDERATIONS IN RELATION TO THE RISK OF TYPE 2 DIABETES
SO DRUGS OF THE FUTURE
LA English
DT Review
ID VIRGIN OLIVE OIL; LIFE-STYLE; INSULIN-RESISTANCE; GLYCEMIC INDEX;
   SWEETENED BEVERAGES; METABOLIC SYNDROME; GLUCOSE-TOLERANCE;
   PIMA-INDIANS; WHOLE GRAINS; WEIGHT-GAIN
AB The dramatic increase in diabetes incidence worldwide has been attributed to various factors, including major lifestyle changes, over the post few decades. One lifestyle-related factor is the increased intake of food with a high glycemic index. The resulting high demand for insulin promotes insulin resistance and beta-cell insufficiency. Together with decreased physical exercise, this predisposes individuals to the development of type 2 diabetes. Oxidative stress also ploys a role in the pathogenesis of insulin resistance and it has been hypothesized that dietary antioxidants could diminish the risk of type 2 diabetes. Therefore, specific dietary strategies may contribute to improved glucose homoeostasis and help in the prevention of this disease. The epidemiological evidence and molecular details that link the Mediterranean diet, typically rich in antioxidants, with the decreased risk for type 2 diabetes are discussed in this review. It is concluded that prospective observational studies and intervention studies support on inverse relationship between this diet and insulin resistance with the resulting type 2 diabetes.
C1 Univ Pisa, Sch Med, I-56100 Pisa, Italy.
C3 University of Pisa
RP Pauwels, EKJ (corresponding author), Univ Pisa, Sch Med, I-56100 Pisa, Italy.
EM ernestpauwels@gmail.com
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NR 93
TC 2
Z9 2
U1 0
U2 11
PU PROUS SCIENCE, SAU-THOMSON REUTERS
PI BARCELONA
PA 398 PROVENCA, 08025 BARCELONA, SPAIN
SN 0377-8282
EI 2013-0368
J9 DRUG FUTURE
JI Drug Future
PD NOV
PY 2009
VL 34
IS 11
BP 903
EP 909
DI 10.1358/dof.2009.034.11.1436080
PG 7
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 567YY
UT WOS:000275486800005
DA 2025-06-11
ER

PT J
AU Bonizzi, A
   Piuri, G
   Corsi, F
   Cazzola, R
   Mazzucchelli, S
AF Bonizzi, Arianna
   Piuri, Gabriele
   Corsi, Fabio
   Cazzola, Roberta
   Mazzucchelli, Serena
TI HDL Dysfunctionality: Clinical Relevance of Quality Rather Than Quantity
SO BIOMEDICINES
LA English
DT Review
DE high-density lipoproteins; HDL cholesterol; dysfunctional HDL; obesity;
   diabetes mellitus type 2; cardiovascular disease
ID HIGH-DENSITY-LIPOPROTEIN; CHOLESTEROL EFFLUX CAPACITY;
   APOLIPOPROTEIN-A-I; FATTY LIVER-DISEASE; METABOLIC SYNDROME;
   CARDIOVASCULAR-DISEASE; MOLECULAR-MECHANISMS; SERUM TRIGLYCERIDE;
   DIABETES-MELLITUS; INHIBITS 3
AB High-density lipoproteins (HDLs) represent a class of lipoproteins very heterogeneous in structure, composition, and biological functions, which carry out reverse cholesterol transport, antioxidant, anti-inflammatory, antithrombotic, and vasodilator actions. Despite the evidence suggesting a clear inverse relationship between HDL cholesterol (HDL-c) concentration and the risk for cardiovascular disease, plasma HDL cholesterol levels do not predict the functionality and composition of HDLs. The importance of defining both the amount of cholesterol transported and lipoprotein functionality has recently been highlighted. Indeed, different clinical conditions such as obesity, diabetes mellitus type 2 (T2DM), and cardiovascular disease (CVD) can alter the HDL functionality, converting normal HDLs into dysfunctional ones, undergoing structural changes, and exhibiting proinflammatory, pro-oxidant, prothrombotic, and proapoptotic properties. The aim of the current review is to summarize the actual knowledge concerning the physical-chemical alteration of HDLs related to their functions, which have been found to be relevant in several pathological conditions associated with systemic inflammation and oxidative stress.
C1 [Bonizzi, Arianna; Piuri, Gabriele; Corsi, Fabio; Cazzola, Roberta; Mazzucchelli, Serena] Univ Milan, Dept Biomed & Clin Sci L Sacco, I-20157 Milan, Italy.
   [Corsi, Fabio] Ist Clin Sci Maugeri IRCCS, I-27100 Pavia, Italy.
C3 University of Milan; Luigi Sacco Hospital
RP Cazzola, R (corresponding author), Univ Milan, Dept Biomed & Clin Sci L Sacco, I-20157 Milan, Italy.
EM arianna.bonizzi@unimi.It; gabriele.piuri@me.com;
   fabio.corsi@icsmaugeri.it; roberta.cazzola@unimi.it;
   serena.mazzucchelli@unimi.it
RI Bonizzi, Arianna/AHE-5627-2022; Corsi, Fabio/ABH-9554-2020; Piuri,
   Gabriele/AAA-4844-2022; cazzola, roberta/A-1023-2008; Mazzucchelli,
   Serena/I-9982-2018; Corsi, Fabio/E-9204-2017
OI cazzola, roberta/0000-0002-0778-8529; Mazzucchelli,
   Serena/0000-0001-6904-8895; Bonizzi, Arianna/0000-0002-5948-8747; Corsi,
   Fabio/0000-0002-6469-4086; Piuri, Gabriele/0000-0002-2925-3007
FU University of Milan
FX This research received no external funding. The APC was funded by the
   University of Milan.
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NR 112
TC 28
Z9 33
U1 1
U2 12
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2227-9059
J9 BIOMEDICINES
JI Biomedicines
PD JUL
PY 2021
VL 9
IS 7
AR 729
DI 10.3390/biomedicines9070729
PG 14
WC Biochemistry & Molecular Biology; Medicine, Research & Experimental;
   Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Research & Experimental Medicine;
   Pharmacology & Pharmacy
GA TQ3NZ
UT WOS:000678191600001
PM 34202201
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Thon, M
   Hosoi, T
   Chea, C
   Ozawa, K
AF Thon, Mina
   Hosoi, Toru
   Chea, Chanbora
   Ozawa, Koichiro
TI Loss of Stearoyl-CoA Desaturase-1 Activity Induced Leptin Resistance in
   Neuronal Cells
SO BIOLOGICAL & PHARMACEUTICAL BULLETIN
LA English
DT Article
DE saturated fatty acid (SFA); palmitate; stearoyl-CoA desaturase-1 (SCD1);
   leptin; leptin resistance; obesity
ID ENDOPLASMIC-RETICULUM STRESS; UNFOLDED PROTEIN RESPONSE; DIET-INDUCED
   OBESITY; INSULIN-RESISTANCE; METABOLIC SYNDROME; A DESATURASE;
   FATTY-ACIDS; BODY-WEIGHT; KAPPA-B; MICE
AB The lack of response to leptin's actions in the brain, "leptin resistance," is one of the main causes of the pathogenesis of obesity. However, although high-fat diets affect sensitivity to leptin, the underlying mechanisms of leptin resistance are still an enigma. Here we examined the effect of excess saturated fatty acids (SFAs) on leptin signaling in human neuronal cells. Palmitate, the principle source of SFAs in diet, induced leptin resistance in a human neuroblastoma cell line stably transfected with the Ob-Rb leptin receptor (SH-SY5Y-ObRb). We next investigated the function of stearoyl-CoA desaturase-1 (SCD1), an enzyme which converts SFAs into monounsaturated fatty acids (MUFAs), on leptin-induced signaling. We found that reduction of SCD1 activity, through SCD1 inhibition and knockdown, impairs leptin-induced signal transducer and activator of transcription 3 (STAT3) phosphorylation in human neuronal cells. Our findings suggested that SCD1 plays a key role in the pathophysiology of leptin resistance in neuronal cells associated with obesity.
C1 [Thon, Mina; Hosoi, Toru; Ozawa, Koichiro] Hiroshima Univ, Grad Sch Biomed & Hlth Sci, Dept Pharmacotherapy, Minami Ku, 1-2-3 Kasumi, Hiroshima 7348551, Japan.
   [Chea, Chanbora] Hiroshima Univ, Grad Sch Biomed & Hlth Sci, Dept Oral & Maxillofacial Pathobiol, Minami Ku, 1-2-3 Kasumi, Hiroshima 7348551, Japan.
C3 Hiroshima University; Hiroshima University
RP Hosoi, T; Ozawa, K (corresponding author), Hiroshima Univ, Grad Sch Biomed & Hlth Sci, Dept Pharmacotherapy, Minami Ku, 1-2-3 Kasumi, Hiroshima 7348551, Japan.
EM toruh@hiroshima-u.ac.jp; ozawak@hiroshima-u.ac.jp
RI Hosoi, Toru/A-7954-2018
FU Kobayashi International Scholarship Foundation; JSPS KAKENHI; Takeda
   Science Foundation
FX This research was supported by the Kobayashi International Scholarship
   Foundation, JSPS KAKENHI, and Takeda Science Foundation.
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NR 37
TC 7
Z9 8
U1 0
U2 10
PU PHARMACEUTICAL SOC JAPAN
PI TOKYO
PA 2-12-15 SHIBUYA, SHIBUYA-KU, TOKYO, 150-0002, JAPAN
SN 0918-6158
J9 BIOL PHARM BULL
JI Biol. Pharm. Bull.
PD AUG
PY 2017
VL 40
IS 8
BP 1161
EP 1164
DI 10.1248/bpb.b17-00311
PG 4
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA FC4OZ
UT WOS:000406821600006
PM 28768997
OA gold
DA 2025-06-11
ER

PT J
AU Somogyi, A
   Horvai, G
   Csala, M
   Tóth, B
AF Somogyi, Anna
   Horvai, George
   Csala, Miklos
   Toth, Blanka
TI Analytical Approaches for the Quantitation of Redox-active Pyridine
   Dinucleotides in Biological Matrices
SO PERIODICA POLYTECHNICA-CHEMICAL ENGINEERING
LA English
DT Article
DE nicotinamide adenine dinucleotide; redox couple; separation; HPLC; mass
   spectrometry; method
ID TANDEM MASS-SPECTROMETRY; PERFORMANCE LIQUID-CHROMATOGRAPHY;
   HYDROPHILIC-INTERACTION CHROMATOGRAPHY;
   NICOTINAMIDE-ADENINE-DINUCLEOTIDE; ENDOPLASMIC-RETICULUM;
   CAPILLARY-ELECTROPHORESIS; INTRACELLULAR METABOLITES; INTERNAL
   STANDARDS; POLAR COMPOUNDS; NUCLEOTIDES
AB Some of the main electron carriers in the metabolism are mono- or dinucleotides and they play crucial roles in maintaining a balanced redox homeostasis of cells, and in coupling many anabolic and catabolic reactions. Altered cellular redox status can be an indicator of various metabolic disorders such as obesity, the metabolic syndrome, or type 2 diabetes and of other pathological conditions, which involve oxidative stress, such as cardiovascular diseases. Adequate NAD(+)/NADH and NADP(+)/NADPH ratios are fundamental for normal cellular functions, thus accurate measurement of these pyridine dinucleotides is essential in biochemical research. Liquid chromatography coupled to tandem mass spectrometry has become the leading analytical technology in (targeted) state-of-the-art metabolic profiling. Main difficulties that hamper quantification of metabolites are chemical similarities, high polarity, and chemical and biological instability of the molecules to be measured. In this review, some critical steps of studying cellular redox status are described, in particular, different techniques of sample preparation and challenges in chromatographic separation.
C1 [Somogyi, Anna; Horvai, George; Toth, Blanka] Budapest Univ Technol & Econ, Dept Inorgan & Analyt Chem, H-1111 Budapest, Hungary.
   [Horvai, George] MTA BME Res Grp Tech & Analyt Chem, H-1111 Budapest, Hungary.
   [Csala, Miklos] Semmelweis Univ, Dept Med Chem Mol Biol & Pathobiochem, H-1144 Budapest, Hungary.
C3 Budapest University of Technology & Economics; Budapest University of
   Technology & Economics; Semmelweis University
RP Tóth, B (corresponding author), Budapest Univ Technol & Econ, Dept Inorgan & Analyt Chem, H-1111 Budapest, Hungary.
EM tblanka@mail.bme.hu
RI Csala, Miklos/H-5369-2011; Somogyi, Anna/R-2243-2016
OI Csala, Miklos/0000-0002-3829-4361; Toth, Blanka/0000-0002-9944-4175
FU Hungarian Scientific Research Fund [OTKA 106060]
FX The authors thank the Hungarian Scientific Research Fund (OTKA 106060)
   for its support.
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NR 39
TC 6
Z9 7
U1 0
U2 8
PU BUDAPEST UNIV TECHNOLOGY ECONOMICS
PI BUDAPEST
PA PERIODICA POLYTECHNICA CIVIL ENGINEERING, BUDAPEST, 1521, HUNGARY
SN 0324-5853
EI 1587-3765
J9 PERIOD POLYTECH-CHEM
JI Period. Polytech.-Chem. Eng.
PY 2016
VL 60
IS 4
BP 218
EP 230
DI 10.3311/PPch.9470
PG 13
WC Engineering, Chemical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering
GA EJ3WL
UT WOS:000393142800001
OA Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Delbin, MA
   Trask, AJ
AF Delbin, Maria A.
   Trask, Aaron J.
TI The diabetic vasculature: Physiological mechanisms of dysfunction and
   influence of aerobic exercise training in animal models
SO LIFE SCIENCES
LA English
DT Review
DE Diabetes mellitus; Vascular responsiveness; Vascular remodeling; Aerobic
   exercise training
ID ENDOTHELIUM-DEPENDENT RELAXATION; SMALL MESENTERIC-ARTERIES; GLYCATION
   END-PRODUCTS; NITRIC-OXIDE SYNTHASE; OXIDATIVE STRESS; SMOOTH-MUSCLE;
   PHYSICAL-ACTIVITY; METABOLIC SYNDROME; GENE-EXPRESSION;
   MOLECULAR-MECHANISMS
AB Diabetes mellitus (DM) is associated with a number of complications of which chronic vascular complications are undoubtedly the most complex and significant consequence. With a significant impact on health care, 50-80% of people with diabetes die of cardiovascular disease (including coronary artery disease, stroke, peripheral vascular disease and other vascular disease), making it the major cause of morbidity and mortality in diabetic patients. A healthy lifestyle is essential in the management of DM, especially the inclusion of aerobic exercise, which has been shown effective in reducing the deleterious effects in vasculature. Interest in exercise studies has increased significantly with promising results that demonstrate a future for investigation. Considering the importance of this emerging field, the aim of this mini-review is to summarize and integrate animal studies investigating physiological mechanisms of vascular dysfunction and remodeling in type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) and how these are influenced by chronic aerobic exercise training. (C) 2014 Elsevier Inc. All rights reserved.
C1 [Delbin, Maria A.] Univ Campinas UNICAMP, Inst Biol, Dept Struct & Funct Biol, Campinas, SP, Brazil.
   [Trask, Aaron J.] Nationwide Childrens Hosp, Res Inst, Ctr Cardiovasc & Pulm Res, Columbus, OH USA.
   [Trask, Aaron J.] Nationwide Childrens Hosp, Res Inst, Ctr Heart, Columbus, OH USA.
   [Trask, Aaron J.] Ohio State Univ, Coll Med, Dept Pediat, Columbus, OH 43210 USA.
C3 Universidade de Sao Paulo; Universidade Estadual de Campinas; University
   System of Ohio; Ohio State University; Nationwide Childrens Hospital;
   Research Institute at Nationwide Children's Hospital; Center for
   Cardiovascular & Pulmonary Research; University System of Ohio; Ohio
   State University; Nationwide Childrens Hospital; Research Institute at
   Nationwide Children's Hospital; Center for Cardiovascular & Pulmonary
   Research; University System of Ohio; Ohio State University
RP Delbin, MA (corresponding author), Rua Monteiro Lobato 255, Campinas, SP, Brazil.
EM nadelbin@hotmail.com
RI Delbin, Maria/F-4233-2012; Trask, Aaron/I-4076-2013
OI Delbin, Maria/0000-0002-3537-055X
FU Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP); American
   Heart Association [13SDG16840035]; American Heart Association (AHA)
   [13SDG16840035] Funding Source: American Heart Association (AHA)
FX M.A. Delbin is supported by the Fundacao de Amparo a Pesquisa do Estado
   de Sao Paulo (FAPESP). A.J. Trask is supported by the American Heart
   Association (13SDG16840035).
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NR 120
TC 18
Z9 22
U1 0
U2 30
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0024-3205
EI 1879-0631
J9 LIFE SCI
JI Life Sci.
PD APR 25
PY 2014
VL 102
IS 1
BP 1
EP 9
DI 10.1016/j.lfs.2014.02.021
PG 9
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA AG0GR
UT WOS:000335094400001
PM 24583313
DA 2025-06-11
ER

PT J
AU Ramsey, JM
   Guest, PC
   Broek, JAC
   Glennon, JC
   Rommelse, N
   Franke, B
   Rahmoune, H
   Buitelaar, JK
   Bahn, S
AF Ramsey, Jordan M.
   Guest, Paul C.
   Broek, Jantine A. C.
   Glennon, Jeffrey C.
   Rommelse, Nanda
   Franke, Barbara
   Rahmoune, Hassan
   Buitelaar, Jan K.
   Bahn, Sabine
TI Identification of an age-dependent biomarker signature in children and
   adolescents with autism spectrum disorders
SO MOLECULAR AUTISM
LA English
DT Article
DE Autism; Age; Biomarkers; Molecular profiling; Inflammation; Metabolism
ID METABOLIC SYNDROME; GROWTH-FACTOR; MALADAPTIVE BEHAVIORS; IMMUNE
   DYSFUNCTION; OXIDATIVE STRESS; SERUM-LEVELS; SYMPTOMS; ADIPONECTIN;
   BRAIN; SCHIZOPHRENIA
AB Background: Autism spectrum disorders (ASDs) are neurodevelopmental conditions with symptoms manifesting before the age of 3, generally persisting throughout life and affecting social development and communication. Here, we have investigated changes in protein biomarkers in blood during childhood and adolescent development.
   Methods: We carried out a multiplex immunoassay profiling analysis of serum samples from 37 individuals with a diagnosis of ASD and their matched, non-affected siblings, aged between 4 and 18 years, to identify molecular pathways affected over the course of ASDs.
   Results: This analysis revealed age-dependent differences in the levels of 12 proteins involved in inflammation, growth and hormonal signaling.
   Conclusions: These deviations in age-related molecular trajectories provide further insight into the progression and pathophysiology of the disorder and, if replicated, may contribute to better classification of ASD individuals, as well as to improved treatment and prognosis. The results also underline the importance of stratifying and analyzing samples by age, especially in ASD and potentially other developmental disorders.
C1 [Ramsey, Jordan M.; Guest, Paul C.; Broek, Jantine A. C.; Rahmoune, Hassan; Bahn, Sabine] Univ Cambridge, Dept Chem Engn & Biotechnol, Cambridge CB2 1QT, England.
   [Glennon, Jeffrey C.] Radboud Univ Nijmegen, Med Ctr, Dept Cognit Neurosci, Donders Inst Brain Cognit & Behav, NL-6525 EZ Nijmegen, Netherlands.
   [Rommelse, Nanda; Franke, Barbara; Buitelaar, Jan K.] Radboud Univ Nijmegen, Med Ctr, Dept Psychiat, Donders Inst Brain Cognit & Behav, NL-6525 EZ Nijmegen, Netherlands.
   [Rommelse, Nanda; Buitelaar, Jan K.] Karakter Child & Adolescent Psychiat Univ Ctr, NL-6525 GA Nijmegen, Netherlands.
   [Franke, Barbara] Radboud Univ Nijmegen, Med Ctr, Dept Genet, Donders Inst Brain Cognit & Behav, NL-6500 HB Nijmegen, Netherlands.
   [Bahn, Sabine] Erasmus MC, Dept Neurosci, NL-3015 CE Rotterdam, Netherlands.
C3 University of Cambridge; Radboud University Nijmegen; Radboud University
   Nijmegen; Radboud University Nijmegen; Radboud University Nijmegen;
   Erasmus University Rotterdam; Erasmus MC
RP Bahn, S (corresponding author), Univ Cambridge, Dept Chem Engn & Biotechnol, Tennis Court Rd, Cambridge CB2 1QT, England.
EM sb209@cam.ac.uk
RI Rommelse, Nanda/D-4872-2009; Buitelaar, Jan/AAY-7522-2020; Glennon,
   Jeffrey/AAK-8394-2020; Franke, Barbara/D-4836-2009
OI Franke, Barbara/0000-0003-4375-6572; guest, paul/0000-0002-5030-7137;
   Glennon, Jeffrey/0000-0002-2371-0422
FU Autism Speaks [6009]; EU FP7 TACTICS Translational Adolescent and
   Childhood Therapeutic Interventions in Compulsive Syndromes [278948];
   Dutch Fund for Economic Structure Reinforcement (FES) [0908]; de
   Hersenstichting Nederland [15F.07]; Netherlands Organization for
   Scientific Research (NWO, Veni grant)
FX This work was funded by Autism Speaks Grant #6009, EU FP7 TACTICS
   Translational Adolescent and Childhood Therapeutic Interventions in
   Compulsive Syndromes. Grant No. Project number 278948, the Dutch Fund
   for Economic Structure Reinforcement (FES), under grant agreement number
   0908 (NeuroBasic PharmaPhenomics project), by de Hersenstichting
   Nederland (grant 15F.07) to Jan Buitelaar) and the Netherlands
   Organization for Scientific Research (NWO, Veni grant to Nanda
   Rommelse).
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NR 52
TC 26
Z9 26
U1 0
U2 14
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 2040-2392
J9 MOL AUTISM
JI Mol. Autism
PD AUG 6
PY 2013
VL 4
AR 27
DI 10.1186/2040-2392-4-27
PG 9
WC Genetics & Heredity; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Genetics & Heredity; Neurosciences & Neurology
GA 254WY
UT WOS:000327201200001
PM 23915542
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Uslu, S
   Kebapçi, N
   Kara, M
   Bal, C
AF Uslu, Sema
   Kebapci, Nur
   Kara, Mehmet
   Bal, Cengiz
TI Relationship between adipocytokines and cardiovascular risk factors in
   patients with type 2 diabetes mellitus
SO EXPERIMENTAL AND THERAPEUTIC MEDICINE
LA English
DT Article
DE adipocytokines; cardiovascular risk markers; type 2 diabetes mellitus
ID INSULIN-RESISTANCE; ASYMMETRIC DIMETHYLARGININE; HOMOCYSTEINE LEVELS;
   METABOLIC SYNDROME; ADIPONECTIN LEVELS; JAPANESE PATIENTS; OXIDATIVE
   STRESS; SERUM VISFATIN; LEPTIN; DISEASE
AB The aim of this study was to explore the relationship between serum profiles of adiponectin, leptin, resistin and visfatin and traditional and non-traditional cardiovascular risk factors in patients with type 2 diabetes mellitus (T2DM). A total of 85 patients with T2DM and 30 non-diabetic controls were enrolled in the study. Levels of adipocytokines (adiponectin, leptin, resistin and visfatin), lipids (total cholesterol, triglycerides), lipoproteins [HDL-cholesterol, LDL-cholesterol, lipoprotein (a)], apolipoproteins (Apo-A1 and Apo-B), non-traditional cardiovascular risk markers [asymmetric dimethylarginine (ADMA), homocysteine] and the inflammatory marker hs-CRP were measured, and anthropometric variables were determined. Serum adiponectin levels were decreased and leptin, resistin and visfatin levels were increased in T2DM patients compared to controls. They were associated with obesity (BM I), insulin resistance (HOMA-IR) and various markers of glucose/lipid profile, inflammation and endothelial dysfunction markers. These results suggest that decreased serum adiponectin and increased leptin, resistin and visfatin levels in T2DM may be novel biochemical risk factors for cardiovascular complications.
C1 [Uslu, Sema; Kara, Mehmet] Eskisehir Osmangazi Univ, Sch Med, Dept Med Biochem, TR-26480 Eskisehir, Turkey.
   [Kebapci, Nur] Eskisehir Osmangazi Univ, Sch Med, Dept Endocrinol, TR-26480 Eskisehir, Turkey.
   [Bal, Cengiz] Eskisehir Osmangazi Univ, Sch Med, Dept Biostat, TR-26480 Eskisehir, Turkey.
C3 Eskisehir Osmangazi University; Eskisehir Osmangazi University;
   Eskisehir Osmangazi University
RP Uslu, S (corresponding author), Eskisehir Osmangazi Univ, Sch Med, Dept Med Biochem, TR-26480 Eskisehir, Turkey.
EM suslu@ogu.edu.tr
RI BAL, CENGIZ/V-4637-2017; KARA, Mehmet/D-9361-2013
OI BAL, CENGIZ/0000-0002-1553-2902; KARA, Mehmet/0000-0002-4287-5433
FU Scientific Research Projects Commission of Eskisehir Osmangazi
   University [2006-11031]
FX This study was supported by grants from the Scientific Research Projects
   Commission of Eskisehir Osmangazi University (2006-11031).
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NR 50
TC 70
Z9 79
U1 1
U2 25
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1792-0981
EI 1792-1015
J9 EXP THER MED
JI Exp. Ther. Med.
PD JUL
PY 2012
VL 4
IS 1
BP 113
EP 120
DI 10.3892/etm.2012.557
PG 8
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 955UJ
UT WOS:000305046100020
PM 23060933
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Shehab-Eldin, W
   Zaki, A
   Gazareen, S
   Shoker, A
AF Shehab-Eldin, Walid
   Zaki, Ali
   Gazareen, Sanaa
   Shoker, Ahmed
TI Susceptibility to Hyperglycemia in Patients with Chronic Kidney Disease
SO AMERICAN JOURNAL OF NEPHROLOGY
LA English
DT Article
DE Insulin resistance; Adiponectin; Reactive oxygen species; Inflammation;
   Hyperglycemia; Kidney diseases
ID C-REACTIVE PROTEIN; BETA-CELL FUNCTION; MOLECULAR-WEIGHT ADIPONECTIN;
   INSULIN-RESISTANCE; GLUCOSE-INTOLERANCE; OXIDATIVE STRESS; PLASMA
   ADIPONECTIN; METABOLIC SYNDROME; SENSITIVITY; ISLET
AB Background: Patients with chronic kidney disease (CKD) are susceptible to hyperglycemia. Aim: To study the prevalence of pre-diabetes in CKD patients and determine the contribution of insulin resistance (IR) versus beta-cell dysfunction in patients with CKD. Methods: 45 consecutive nondiabetic CKD patients and 40 healthy subjects were included. Patients were divided into a normoglycemic (NG) and a pre-diabetic (PDM) group. IR was assessed by homeostasis model assessment of insulin resistance (HOMA-IR) and beta-cell function was assessed by proinsulin/insulin ratio and beta-cell%. Results: The prevalence of PDM was 40%. The prevalence of high HOMA-IR was 22.2 and 77.8% in the NG and PDM groups. Compared to NG patients, the PDM group showed higher fasting plasma glucose, HOMA-IR, insulin, and proinsulin, while the prevalence of beta-cell dysfunction of 22.2% was lower than the 37% present in the NG group. Conclusion: Increased IR, rather than beta-cell dysfunction, is the primary mechanism of PDM in CKD patients. Copyright (c) 2008 S. Karger AG, Basel
C1 [Shoker, Ahmed] Univ Saskatchewan, Dept Med, Div Nephrol, Saskatoon, SK S7N 0W8, Canada.
   [Shehab-Eldin, Walid; Zaki, Ali; Gazareen, Sanaa] Menoufia Univ, Fac Med, Dept Internal Med, Cairo, Egypt.
C3 University of Saskatchewan; Egyptian Knowledge Bank (EKB); Menofia
   University
RP Shoker, A (corresponding author), Univ Saskatchewan, Dept Med, Div Nephrol, 103 Hosp Dr, Saskatoon, SK S7N 0W8, Canada.
EM shoker@sask.usask.ca
RI Shehabeldin, Walid/AAJ-1875-2021
OI Shehab-Eldin, Walid/0000-0002-4736-9310
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NR 34
TC 7
Z9 7
U1 0
U2 2
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0250-8095
EI 1421-9670
J9 AM J NEPHROL
JI Am. J. Nephrol.
PY 2009
VL 29
IS 5
DI 10.1159/000171379
PG 8
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 428SO
UT WOS:000264870200009
PM 18997456
DA 2025-06-11
ER

PT J
AU Gal, AM
   Iatcu, CO
   Popa, AD
   Arhire, LI
   Mihalache, L
   Gherasim, A
   Nita, O
   Soimaru, RM
   Gheorghita, R
   Graur, M
   Covasa, M
AF Gal, Ana Maria
   Iatcu, Camelia Oana
   Popa, Alina Delia
   Arhire, Lidia Iuliana
   Mihalache, Laura
   Gherasim, Andreea
   Nita, Otilia
   Soimaru, Raluca Meda
   Gheorghita, Roxana
   Graur, Mariana
   Covasa, Mihai
TI Understanding the Interplay of Dietary Intake and Eating Behavior in
   Type 2 Diabetes
SO NUTRIENTS
LA English
DT Article
DE diabetes mellitus; T2DM; EPIC FFQ; DEBQ; emotional eating; external
   eating; restrained eating
ID METABOLIC SYNDROME; FOOD-INTAKE; STRESS; NUTRITION; ADULTS;
   QUESTIONNAIRE; ASSOCIATIONS; METAANALYSIS; CONSUMPTION; PREVALENCE
AB Diet and eating behavior both play a crucial role in the prevention and management of type 2 diabetes mellitus (T2DM). The main objective of this study was to investigate the relationship between dietary intake and eating behavior in a population of patients with T2DM. A cross-sectional study was performed using 416 patients with T2DM and their dietary intake and eating behavior were assessed with validated questionnaires. Women scored significantly higher than men for emotional and restrained eating (p < 0.001). Correlation analyses showed that emotional eaters consumed significantly more calories (r = 0.120, p = 0.014) and fat (r = 0.101, p = 0.039), as well as non-alcoholic beverages for women (r = 0.193, p = 0.003) and alcohol for men (r = 0.154, p = 0.038). Also, individuals who ate based on external cues consumed significantly more calories (r = 0.188, p < 0.001) and fat (r = 0.139, p = 0.005). These results demonstrate that eating behavior influences dietary intake. Understanding this relationship could optimize diabetes management and allow for more individualized nutritional guidance.
C1 [Gal, Ana Maria; Iatcu, Camelia Oana; Popa, Alina Delia; Arhire, Lidia Iuliana; Mihalache, Laura; Gherasim, Andreea; Nita, Otilia; Soimaru, Raluca Meda] Grigore T Popa Univ Med & Pharm, Fac Med, Iasi 700115, Romania.
   [Gal, Ana Maria; Iatcu, Camelia Oana; Soimaru, Raluca Meda; Gheorghita, Roxana; Graur, Mariana; Covasa, Mihai] Stefan cel Mare Univ, Fac Med & Biol Sci, Dept Biomed Sci, Suceava 720229, Romania.
C3 Grigore T Popa University of Medicine & Pharmacy; Stefan cel Mare
   University of Suceava
RP Arhire, LI (corresponding author), Grigore T Popa Univ Med & Pharm, Fac Med, Iasi 700115, Romania.
EM ana-maria.a.ilisei@d.umfiasi.ro; oana.iatcu@usm.ro;
   alina.popa@umfiasi.ro; lidia.graur@umfiasi.ro;
   laura.mihalache@umfiasi.ro; andreea.gherasim@umfiasi.ro;
   otilia.nita@umfiasi.ro; raluca-meda-m-frigura@d.umfiasi.ro;
   roxana.puscaselu@usm.ro; mariana.graur@usm.ro; mcovasa@westernu.edu
RI Iatcu, Camelia/AAQ-7392-2021; Mihalache, Laura/K-1529-2019; Arhire,
   Lidia/AAW-2920-2020; Gherasim, Andreea/KZU-9980-2024; Gal, Ana
   Maria/KPY-1788-2024; popa, alina delia/ABG-7843-2020
OI Nita, Otilia/0000-0003-0468-1141; popa, alina delia/0000-0003-0639-0479;
   Gal, Ana-Maria/0000-0003-0986-3227
FU European Regional Development Fund
FX No Statement Available
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NR 81
TC 4
Z9 4
U1 2
U2 5
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD MAR
PY 2024
VL 16
IS 6
AR 771
DI 10.3390/nu16060771
PG 15
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA MK7D6
UT WOS:001193571300001
PM 38542683
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Wang, ZY
   Yang, Y
   Zhang, JW
   Hu, JM
   Yan, X
   Zeng, SX
   Huang, XJ
   Lin, SL
AF Wang, Zhenyu
   Yang, Yang
   Zhang, Jiawen
   Hu, Jiamiao
   Yan, Xin
   Zeng, Shaoxiao
   Huang, Xiujuan
   Lin, Shaoling
TI Ferulic acid ameliorates intrahepatic triglyceride accumulation in
   vitro but not in high fat diet-fed C57BL/6 mice
SO FOOD AND CHEMICAL TOXICOLOGY
LA English
DT Article
DE Ferulic acid; HepG2 cells; HFD-Fed mice; Cellular lipid; Hepatic
   steatosis
ID INSULIN-RESISTANCE; HEPATIC STEATOSIS; OBESITY; METABOLISM; EXPRESSION;
   STRESS; CELLS
AB Phenolic acids can improve obesity-related and metabolic syndrome-related conditions including non-alcoholic fatty liver disease (NAFLD). In this study, the effects of ferulic acid (FA) on the metabolic changes related to NAFLD were investigated in oleic acid (OA)-treated HepG2 cells and C57BL/6 mice fed a high fat diet (HFD). In vitro, FA (25 and 50 mu g/mL) treatment significantly reduced cellular lipid accumulation with no obvious cytotoxicity, in-part mediated by the suppression of ERK1/2, JNK1/2/3, and HGMB1 expression. However, in vivo administration of FA (20 mg/kg bw.day) for 17 weeks led to no obvious effects on body weight and liver weight gain, blood lipid profiles, or histological abnormalities in obese C57BL/6 mice induced by HFD. Taken together, the positive effects of FA on the reduction of hepatic triglyceride accumulation were therefore demonstrated in cellular model, while its hepatic protective effects might need to be further explored in rodent models and clinical trials.
C1 [Wang, Zhenyu; Yang, Yang; Zhang, Jiawen; Hu, Jiamiao; Yan, Xin; Zeng, Shaoxiao; Lin, Shaoling] Fujian Agr & Forestry Univ, Coll Food Sci, Fuzhou 350002, Peoples R China.
   [Huang, Xiujuan] Fujian Saifu Food Inspect Co Ltd, Fuzhou 350011, Peoples R China.
C3 Fujian Agriculture & Forestry University
RP Lin, SL (corresponding author), Fujian Agr & Forestry Univ, Coll Food Sci, Fuzhou 350002, Peoples R China.; Huang, XJ (corresponding author), Fujian Saifu Food Inspect Co Ltd, Fuzhou 350011, Peoples R China.
EM xiujuanhuang@126.com; shaoling.lin@fafu.edu.cn
RI Hu, Jiamiao/W-5312-2019; Wang, Zhenyu/IXD-4651-2023
OI zhenyu, Wang/0000-0003-2965-6997; Hu, Jiamiao/0000-0001-6489-9877; Yang,
   Yang/0000-0002-5005-5558
FU China Postdoctoral Science Foundation [2018M63072, 2019T120551]
FX The authors acknowledge financial support from the China Postdoctoral
   Science Foundation (Grant 2018M63072 & 2019T120551).
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NR 38
TC 17
Z9 17
U1 3
U2 31
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0278-6915
EI 1873-6351
J9 FOOD CHEM TOXICOL
JI Food Chem. Toxicol.
PD MAR
PY 2021
VL 149
AR 111978
DI 10.1016/j.fct.2021.111978
EA JAN 2021
PG 6
WC Food Science & Technology; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Toxicology
GA RB6YZ
UT WOS:000632256600010
PM 33428987
DA 2025-06-11
ER

PT J
AU Anuurad, E
   Bremer, A
   Berglund, L
AF Anuurad, Erdembileg
   Bremer, Andrew
   Berglund, Lars
TI HIV protease inhibitors and obesity
SO CURRENT OPINION IN ENDOCRINOLOGY DIABETES AND OBESITY
LA English
DT Article
DE HIV; lipodystrophy; metabolic disorders; protease inhibitors
ID ACTIVE ANTIRETROVIRAL THERAPY; NAIVE HIV-1-INFECTED PATIENTS;
   HORMONE-RELEASING FACTOR; PLACEBO-CONTROLLED TRIAL; INSULIN-RESISTANCE;
   INFECTED PATIENTS; FAT DISTRIBUTION; BODY-COMPOSITION; GROWTH-HORMONE;
   APOLIPOPROTEIN-B
AB Purpose of review
   To review the current scientific literature and recent clinical trials on HIV protease inhibitors and their potential role in the pathogenesis of lipodystrophy and metabolic disorders.
   Recent findings
   HIV protease inhibitor treatment may affect the normal stimulatory effect of insulin on glucose and fat storage. Further, chronic inflammation from HIV infection and protease inhibitor treatment trigger cellular homeostatic stress responses with adverse effects on intermediary metabolism. The physiologic outcome is such that total adipocyte storage capacity is decreased, and the remaining adipocytes resist further fat storage. This process leads to a pathologic cycle of lipodystrophy and lipotoxicity, a proatherogenic lipid profile, and a clinical phenotype of increased central body fat distribution similar to the metabolic syndrome.
   Summary
   Protease inhibitors are a key component of antiretroviral therapy and have dramatically improved the life expectancy of HIV-infected individuals. However, they are also associated with abnormalities in glucose/lipid metabolism and body fat distribution. Further studies are needed to better define the pathogenesis of protease inhibitor-associated metabolic and body fat changes and their potential treatment.
C1 [Berglund, Lars] Univ Calif Davis, Dept Med, UCD Med Ctr, CTSC, Sacramento, CA 95817 USA.
   [Berglund, Lars] VA No Calif Healthcare Syst, Sacramento, CA USA.
   [Bremer, Andrew] Univ Calif Davis, Dept Pediat, Sacramento, CA 95817 USA.
C3 University of California System; University of California Davis;
   University of California System; University of California Davis
RP Berglund, L (corresponding author), Univ Calif Davis, Dept Med, UCD Med Ctr, CTSC, 2921 Stockton Blvd,Suite 1400, Sacramento, CA 95817 USA.
EM lars.berglund@ucdmc.ucdavis.edu
OI Berglund, Lars/0000-0001-6705-1791
FU National Heart, Lung, and Blood Institute [HL 65938, 62705]; UC Davis
   Clinical and Translational Research Center [RR024146]
FX Supported by grants HL 65938 and 62705 (PI: L Berglund) from the
   National Heart, Lung, and Blood Institute. This work was supported by
   the UC Davis Clinical and Translational Research Center (RR024146). We
   are grateful to Dr David Asmuth for valuable discussions and
   suggestions.
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   2010, HIV DRUG DEV
NR 104
TC 40
Z9 43
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1752-296X
EI 1752-2978
J9 CURR OPIN ENDOCRINOL
JI Curr. Opin. Endocrinol. Diabetes Obes.
PD OCT
PY 2010
VL 17
IS 5
BP 478
EP 485
DI 10.1097/MED.0b013e32833dde87
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 691FJ
UT WOS:000285065400017
PM 20717021
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Kishore, A
   Nampurath, GK
   Mathew, SP
   Zachariah, RT
   Potu, BK
   Rao, MS
   Valiathan, M
   Chamallamudi, MR
AF Kishore, Anoop
   Nampurath, Gopalan Kutty
   Mathew, Suma P.
   Zachariah, Robby T.
   Potu, Bhagath Kumar
   Rao, Muddanna S.
   Valiathan, Manna
   Chamallamudi, Mallikarjuna Rao
TI Antidiabetic effect through islet cell protection in streptozotocin
   diabetes: A preliminary assessment of two thiazolidin-4-ones in Swiss
   albino mice
SO CHEMICO-BIOLOGICAL INTERACTIONS
LA English
DT Article
DE Thiazolidin-4-ones; Hypoglycaemic; Hypolipidaemic; Nicotinic acid
ID GLUCOSE-INFUSION; ADULT-RATS; NEW-MODEL
AB This study was undertaken on the basis of several reports in the literature that pancreatic beta cells are capable of replication/regeneration and also being afforded protection against damage induced by streptozotocin. Nicotinamide was reported to give protection against streptozotocin-induced damage in rats. In the present study, two thiazolidine-4-ones with nicotinamide substitution were administered to Swiss albino mice with streptozotocin diabetes for 15 days. Concurrently, one group received nicotinic acid. Both the test compounds reversed the hyperglycaemia diabetic mice. Damage to pancreatic islets was also reduced in these groups compared to diabetic control and nicotinic acid treated groups. Since these compounds have been earlier found have antioxidant activity, one of the possible mechanisms of action could be by reducing oxidative stress in pancreas. Further, possibly by releasing nicotinamide in vivo, the molecules could have contributed to the NAD pool in pancreas and afforded protection. It is concluded that the test compounds have potential to be developed for multiple beneficial action in conditions like metabolic syndrome. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
C1 [Kishore, Anoop; Nampurath, Gopalan Kutty; Mathew, Suma P.; Zachariah, Robby T.; Chamallamudi, Mallikarjuna Rao] Manipal Coll Pharmaceut Sci, Dept Pharmacol, Manipal 576104, Karnataka, India.
   [Zachariah, Robby T.; Potu, Bhagath Kumar; Rao, Muddanna S.] Kasturba Med Coll & Hosp, Dept Anat, Manipal 576104, Karnataka, India.
   [Valiathan, Manna] Kasturba Med Coll & Hosp, Dept Pathol, Manipal 576104, Karnataka, India.
C3 Manipal Academy of Higher Education (MAHE); Manipal Academy of Higher
   Education (MAHE); Kasturba Medical College, Manipal; Manipal Academy of
   Higher Education (MAHE); Kasturba Medical College, Manipal
RP Nampurath, GK (corresponding author), Manipal Coll Pharmaceut Sci, Dept Pharmacol, Madhava Nagar, Manipal 576104, Karnataka, India.
EM ng.kutty@manipal.edu
RI Rao, Muddanna/LOR-7281-2024; Rao, Chamallamudi/H-6041-2019; Kishore,
   Anoop/H-5052-2019; Bhat, Kumar MR/AAD-8831-2019
OI POTU, BHAGATH KUMAR/0000-0002-7945-5037; Rao,
   Muddanna/0000-0002-8815-2089; Chamallamudi, Mallikarjuna
   Rao/0000-0003-3744-8135; Bhat, Kumar MR/0000-0003-1805-3453
FU Department of Science and Technology (DST), New Delhi
FX The authors wish to thank Manipal University, Manipal for providing the
   seed money to carry out the study. Thanks are also due to Department of
   Science and Technology (DST), New Delhi for funding the purchase of
   instruments under FIST, one of which, the Microtome (Leica) was used for
   making sections for histology slides.
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NR 12
TC 25
Z9 25
U1 0
U2 0
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0009-2797
EI 1872-7786
J9 CHEM-BIOL INTERACT
JI Chem.-Biol. Interact.
PD FEB 12
PY 2009
VL 177
IS 3
BP 242
EP 246
DI 10.1016/j.cbi.2008.10.032
PG 5
WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology
GA 410NQ
UT WOS:000263584900010
PM 19038238
DA 2025-06-11
ER

PT J
AU Shibata, R
   Ouchi, N
   Kihara, S
   Sato, K
   Funahashi, T
   Walsh, K
AF Shibata, R
   Ouchi, N
   Kihara, S
   Sato, K
   Funahashi, T
   Walsh, K
TI Adiponectin stimulates angiogenesis in response to tissue ischemia
   through stimulation of AMP-activated protein kinase signaling
SO JOURNAL OF BIOLOGICAL CHEMISTRY
LA English
DT Article
ID FATTY-ACID OXIDATION; PLASMA-PROTEIN; INSULIN-RESISTANCE; METABOLIC
   SYNDROME; GLUCOSE-TRANSPORT; ENDOTHELIAL-CELLS; GLOBULAR DOMAIN;
   GROWTH-FACTOR; NITRIC-OXIDE; ASSOCIATION
AB Obesity is a risk factor for the development of cardiovascular diseases that are associated with impaired angiogenesis. Adiponectin is an adipocyte-specific adipocytokine with anti-atherogenic and anti-diabetic properties, and its plasma levels are reduced in association with obesity-linked diseases. Here, we investigated whether adiponectin regulates angiogenesis in response to tissue ischemia using adiponectin knock-out ( KO) mice. Angiogenic repair of ischemic hind limbs was impaired in adiponectin-KO mice compared with wildtype (WT) mice as evaluated by laser Doppler flow method and capillary density analyses. Adenovirus-mediated supplement of adiponectin accelerated angiogenic repair in both adiponectin-KO and WT mice. Intramuscular injection of an adenovirus encoding dominant-negative AMP-activated kinase diminished the improvement in limb perfusion seen in WT mice and abolished the adiponectin-induced enhancement of perfusion. These data indicate that adiponectin can function to stimulate angiogenesis in response to ischemic stress by promoting AMP-activated kinase signaling. Therefore, adiponectin may be useful in the treatment for obesity-related vascular deficiency diseases.
C1 Boston Univ, Sch Med, Whitaker Cardiovasc Inst, Boston, MA 02118 USA.
   Osaka Univ, Grad Sch Med, Dept Internal Med & Mol Sci, Suita, Osaka 5650871, Japan.
C3 Boston University; The University of Osaka
RP Boston Univ, Sch Med, Whitaker Cardiovasc Inst, 715 Albany St,W611, Boston, MA 02118 USA.
EM kxwalsh@bu.edu
RI OUCHI, Noriyuki/I-7306-2014
FU NIAMS NIH HHS [AR 40197] Funding Source: Medline; NIA NIH HHS [AG 17241,
   AG 15052] Funding Source: Medline; PHS HHS [HE 23641] Funding Source:
   Medline
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NR 34
TC 274
Z9 329
U1 0
U2 6
PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
PI ROCKVILLE
PA 11200 ROCKVILLE PIKE, SUITE 302, ROCKVILLE, MD, UNITED STATES
SN 0021-9258
EI 1083-351X
J9 J BIOL CHEM
JI J. Biol. Chem.
PD JUL 2
PY 2004
VL 279
IS 27
BP 28670
EP 28674
DI 10.1074/jbc.M402558200
PG 5
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 832KC
UT WOS:000222265400103
PM 15123726
OA hybrid
DA 2025-06-11
ER

PT J
AU Niaura, RS
   Stroud, LR
   Todaro, J
   Ward, KD
   Spiro, A
   Aldwin, C
   Landsberg, L
   Weiss, ST
AF Niaura, RS
   Stroud, LR
   Todaro, J
   Ward, KD
   Spiro, A
   Aldwin, C
   Landsberg, L
   Weiss, ST
TI Associations between repression, general maladjustment, body weight, and
   body shape in older males: The normative aging study
SO INTERNATIONAL JOURNAL OF BEHAVIORAL MEDICINE
LA English
DT Article
DE body mass index; waist-hip ratio; repression; maladjustment;
   personality; body shape
ID CORONARY-HEART-DISEASE; ADIPOSE-TISSUE DISTRIBUTION; REGIONAL FAT
   DISTRIBUTION; DEFENSIVE COPING STYLES; STRESS-INDUCED CORTISOL;
   PSYCHIATRIC ILL-HEALTH; MIDDLE-AGED MEN; METABOLIC SYNDROME;
   CARDIOVASCULAR-DISEASE; RISK-FACTORS
AB We examined relationships between repression, general maladjustment, body mass index (BMI), and waist-to-hip ratio (WHR). The participants were 1,081 healthy older men from the Normative Aging Study. Repression and General Maladjustment Scales of the Minnesota Multiphasic Personality Inventory were composite measures of personality. Repression was associated with lower BMI and WHR, and maladjustment with higher BMI and WHR. However, associations between WHR and personality dimensions were no longer significant when controlling for BMI, but associations between BMI and personality dimensions remained significant when controlling for WHR. These effects were explained by differing relationships between WHR, repression, and maladjustment for normal weight, overweight, and obese individuals. Specifically, associations between repression, maladjustment, and body shape were significant for normal weight and overweight individuals, but not for obese individuals. Health behaviors including smoking did not mediate relationships between repression, maladjustment, and body shape, but might be considered in future studies as mechanisms underlying links between personality and body shape.
C1 Brown Med Sch, Ctr Behav & Prevent Med, Providence, RI 02903 USA.
   Miriam Hosp, Ctr Behav & Prevent Med, Providence, RI USA.
   Univ Memphis, Ctr Community Hlth, Memphis, TN 38152 USA.
   Boston VA Healthcare Syst, Massachusetts Vet Epidemiol Res & Informat Ctr, Normat Aging Study, Boston, MA USA.
   Boston Univ, Sch Publ Hlth, Boston, MA 02215 USA.
   Univ Calif Davis, Dept Human & Community Dev, Davis, CA 95616 USA.
   Northwestern Univ, Feinberg Sch Med, Dept Med, Evanston, IL 60208 USA.
   Brigham & Womens Hosp, Channing Lab, Boston, MA 02115 USA.
   Harvard Univ, Sch Med, Cambridge, MA 02138 USA.
C3 Brown University; Lifespan Health Rhode Island; Miriam Hospital;
   University of Memphis; Harvard University; Harvard University Medical
   Affiliates; US Department of Veterans Affairs; Veterans Health
   Administration (VHA); VA Boston Healthcare System; Boston University;
   University of California System; University of California Davis;
   Northwestern University; Feinberg School of Medicine; Harvard
   University; Harvard University Medical Affiliates; Brigham & Women's
   Hospital; Harvard University
RP Brown Med Sch, Ctr Behav & Prevent Med, Coro W Suite 500,1 Hoppin St, Providence, RI 02903 USA.
EM Raymond_Niaura@brown.edu
RI Aldwin, Carolyn/K-9584-2013; Stroud, Laura/O-7807-2019; Niaura,
   Raymond/AAE-7319-2019
OI Spiro III, Avron/0000-0003-4080-8621; Aldwin,
   Carolyn/0000-0002-7461-5126; Stroud, Laura/0000-0002-2138-968X
FU NHLBI NIH HHS [HL48363, HL32318, HL37871] Funding Source: Medline; NIA
   NIH HHS [AG02287] Funding Source: Medline
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NR 77
TC 4
Z9 4
U1 0
U2 3
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1070-5503
EI 1532-7558
J9 INT J BEHAV MED
JI Int. J. Behav. Med.
PY 2003
VL 10
IS 3
BP 221
EP 238
DI 10.1207/S15327558IJBM1003_03
PG 18
WC Psychology, Clinical
WE Social Science Citation Index (SSCI)
SC Psychology
GA 717JN
UT WOS:000185085500003
PM 14525718
DA 2025-06-11
ER

PT J
AU Ye, J
   Wang, JG
   Liu, RQ
   Shi, Q
   Wang, WX
AF Ye, Jing
   Wang, Jian-Guo
   Liu, Rong-Qiang
   Shi, Qiao
   Wang, Wei-Xing
TI Association between intra-pancreatic fat deposition and diseases of the
   exocrine pancreas: A narrative review
SO WORLD JOURNAL OF GASTROENTEROLOGY
LA English
DT Review
DE Intrapancreatic fat deposition; Pancreatic steatosis; Nonalcoholic fatty
   pancreas disease; Pancreatitis; Pancreatic cancer
ID ECTOPIC FAT; ENDOSCOPIC ULTRASOUND; METABOLIC SYNDROME; QUANTITATIVE
   ASSESSMENT; CLINICAL-SIGNIFICANCE; INSULIN-RESISTANCE; ADIPOSE-TISSUE;
   HIGH-FRUCTOSE; RISK-FACTORS; STEATOSIS
AB Intrapancreatic fat deposition (IPFD) has garnered increasing attention in recent years. The prevalence of IPFD is relatively high and associated with factors such as obesity, age, and sex. However, the pathophysiological mechanisms underlying IPFD remain unclear, with several potential contributing factors, including oxidative stress, alterations in the gut microbiota, and hormonal imbalances. IPFD was found to be highly correlated with the occurrence and prognosis of exocrine pancreatic diseases. Although imaging techniques remain the primary diagnostic approach for IPFD, an expanding array of biomarkers and clinical scoring systems have been identified for screening purposes. Currently, effective treatments for IPFD are not available; however, existing medications, such as glucagon-like peptide-1 receptor agonists, and new therapeutic approaches explored in animal models have shown considerable potential for managing this disease. This paper reviews the pathogenesis of IPFD, its association with exocrine pancreatic diseases, and recent advancements in its diagnosis and treatment, emphasizing the significant clinical relevance of IPFD.
C1 [Ye, Jing; Wang, Jian-Guo; Liu, Rong-Qiang; Wang, Wei-Xing] Wuhan Univ, Dept Gen Surg, Renmin Hosp, 238 Jiefang Rd, Wuhan 430060, Hubei, Peoples R China.
   [Shi, Qiao] Wuhan Univ, Renmin Hosp, Dept Pancreat Surg, Wuhan 430060, Hubei, Peoples R China.
C3 Wuhan University; Wuhan University
RP Wang, WX (corresponding author), Wuhan Univ, Dept Gen Surg, Renmin Hosp, 238 Jiefang Rd, Wuhan 430060, Hubei, Peoples R China.
EM sate.llite@163.com
OI Shi, Qiao/0000-0002-8027-1155
FU National Natural Science Foundation of China [82170651]; Research
   Support Fund of Hubei Microcirculation Society [HBWXH2024(1)-1]
FX Supported by National Natural Science Foundation of China, No. 82170651;
   and the Research Support Fund of Hubei Microcirculation Society, No.
   HBWXH2024(1)-1.
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NR 140
TC 1
Z9 1
U1 4
U2 4
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 7041 Koll Center Parkway, Suite 160, PLEASANTON, CA, UNITED STATES
SN 1007-9327
EI 2219-2840
J9 WORLD J GASTROENTERO
JI World J. Gastroenterol.
PD JAN 14
PY 2025
VL 31
IS 2
AR 101180
DI 10.3748/wjg.v31.i2.101180
PG 16
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA U7I6R
UT WOS:001413488700009
PM 39811515
DA 2025-06-11
ER

PT J
AU Zhu, C
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AF Zhu, Chuang
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SO JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
LA English
DT Review
DE whole grains; phenolic acids; metabolic syndrome; thermal processing;
   nonthermal processing
ID PULSED ELECTRIC-FIELD; ANTIOXIDANT ACTIVITY; FERULIC ACID; BROWN RICE;
   IN-VITRO; GUT MICROBIOTA; COUMARIC ACID; SEEDS; WHEAT; BIOACCESSIBILITY
AB Phenolic acids, essential compounds in whole grains, are renowned for their health-enhancing antioxidant and anti-inflammatory properties. Variations in concentration, particularly of hydroxybenzoic and hydroxycinnamic acids, are observed among grain types. Their antiobesity and antidiabetes effects are linked to their modulation of key signaling pathways like AMPK and PI3K, crucial for metabolic regulation and the body's response to inflammation and oxidative stress. Processing methods significantly influence phenolic acid content and bioavailability in whole grains. Thermal techniques like boiling, baking, or roasting can degrade these compounds, with loss influenced by processing conditions. Nonthermal methods such as germination, fermentation, or their combination, can protect or enhance phenolic acid content under ideal conditions. Novel nonthermal approaches like ultrahigh pressure (UHP), irradiation, and pulsed electric fields (PEF) show promise in preserving these compounds. Further research is needed to fully comprehend the impact mechanisms of these innovative methods on the nutritional and sensory attributes of cereals.
C1 [Zhu, Chuang; Lin, Zihan; Jiang, Huibin; Wei, Fenfen; Wu, Yan; Song, Lihua] Shanghai Jiao Tong Univ, Sch Agr & Biol, Dept Food Sci & Technol, Shanghai 200240, Peoples R China.
   [Song, Lihua] Shanghai Jiao Tong Univ, Ctr Hydrogen Sci, Shanghai 200240, Peoples R China.
C3 Shanghai Jiao Tong University; Shanghai Jiao Tong University
RP Song, LH (corresponding author), Shanghai Jiao Tong Univ, Sch Agr & Biol, Dept Food Sci & Technol, Shanghai 200240, Peoples R China.; Song, LH (corresponding author), Shanghai Jiao Tong Univ, Ctr Hydrogen Sci, Shanghai 200240, Peoples R China.
EM lihuas@sjtu.edu.cn
FU National Natural Science Foundation of China [32172221]; National
   Natural Science Foundation of China [2019-02-08-00-08-F01154]; Shanghai
   Agriculture Applied Technology Development Program, China [SL2020ZD103];
   Oceanic Interdisciplinary Program of Shanghai Jiao Tong University
FX This work was supported by grants from the National Natural Science
   Foundation of China (grant no. 32172221), the Shanghai Agriculture
   Applied Technology Development Program, China (2019-02-08-00-08-F01154),
   and the Oceanic Interdisciplinary Program of Shanghai Jiao Tong
   University (SL2020ZD103).
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NR 158
TC 2
Z9 2
U1 25
U2 43
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0021-8561
EI 1520-5118
J9 J AGR FOOD CHEM
JI J. Agric. Food Chem.
PD OCT 23
PY 2024
VL 72
IS 44
BP 24131
EP 24157
DI 10.1021/acs.jafc.4c05245
EA OCT 2024
PG 27
WC Agriculture, Multidisciplinary; Chemistry, Applied; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture; Chemistry; Food Science & Technology
GA L2I3S
UT WOS:001340131900001
PM 39441722
DA 2025-06-11
ER

PT J
AU Zhao, BY
   Zhang, J
   Zhao, KY
   Zhao, WB
   Shi, YJ
   Liu, J
   Zeng, L
   Wang, CX
   Zeng, X
   Shi, JP
AF Zhao, Baiyun
   Zhang, Jing
   Zhao, Kaiyue
   Zhao, Wenbin
   Shi, Yajuan
   Liu, Jing
   Zeng, Ling
   Wang, Chaoxuan
   Zeng, Xin
   Shi, Junping
TI Study on the mechanism of vitamin E alleviating non-alcoholic fatty
   liver function based on non-targeted metabolomics analysis in rats
SO NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
LA English
DT Article
DE Non-alcoholic fatty liver disease; Vitamin E; Non-targeted metabolomics;
   Biosynthesis of cofactors
ID EXPRESSION; CHOLINE; BETAINE
AB Non-alcoholic fatty liver disease (NAFLD) is a hepatic manifestation of metabolic syndrome. Vitamin E (VE) has antioxidant properties and can mediate lipid metabolism. Non-targeted metabolomics technology was employed to uncover comprehensively the metabolome of VE in NAFLD rats. NAFLD model was created with a high-fat and high-cholesterol diet (HFD) in rats. NAFLD rats in the VE group were given 75 mg/(kg day) VE. The metabolites in the serum of rats were identified via UPLC and Q-TOF/MS analysis. KEGG was applied for the pathway enrichment. VE improved the liver function, lipid metabolism, and oxidative stress in NAFLD rats induced by HFD. Based on the metabolite profile data, 132 differential metabolites were identified between VE group and the HFD group, mainly including pyridoxamine, betaine, and bretylium. According to the KEGG results, biosynthesis of cofactors was a key metabolic pathway of VE in NAFLD rats. VE can alleviate NAFLD induced by HFD, and the underlying mechanism is associated with the biosynthesis of cofactors, mainly including pyridoxine and betaine.
C1 [Zhao, Baiyun; Zeng, Ling; Wang, Chaoxuan] Hangzhou Normal Univ, Drug Clin Trial Inst, Affiliated Hosp, Hangzhou, Peoples R China.
   [Zhang, Jing] Jining Med Univ, Affiliated Hosp, Dept Gastroenterol, Jining, Peoples R China.
   [Zhao, Kaiyue; Zhao, Wenbin] Hangzhou Normal Univ, Med Dept, Affiliated Hosp, Hangzhou, Peoples R China.
   [Shi, Yajuan; Shi, Junping] Hangzhou Normal Univ, Dept Translat Med Ctr, Affiliated Hosp, 126 Wenzhou Rd, Hangzhou 310015, Zhejiang, Peoples R China.
   [Liu, Jing] Hangzhou Normal Univ, Dept Clin Med, Hangzhou, Peoples R China.
   [Zeng, Xin] China Pharmaceut Univ Sch, Tradit Chinese Pharm, Nanjing, Peoples R China.
C3 Hangzhou Normal University; Jining Medical University; Hangzhou Normal
   University; Hangzhou Normal University; Hangzhou Normal University
RP Shi, JP (corresponding author), Hangzhou Normal Univ, Dept Translat Med Ctr, Affiliated Hosp, 126 Wenzhou Rd, Hangzhou 310015, Zhejiang, Peoples R China.
EM 20131004@hznu.edu.cn
RI Zhao, Baiyun/LOS-1751-2024; Zhao, Wenbin/AAS-4373-2021
FU Hangzhou Special Fund for supporting science and technology in the
   development of biomedical and health industries
FX No Statement Available
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NR 39
TC 3
Z9 3
U1 3
U2 27
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0028-1298
EI 1432-1912
J9 N-S ARCH PHARMACOL
JI Naunyn-Schmiedebergs Arch. Pharmacol.
PD JUN
PY 2024
VL 397
IS 6
BP 4299
EP 4307
DI 10.1007/s00210-023-02864-0
EA DEC 2023
PG 9
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA RS4A9
UT WOS:001126678900001
PM 38091076
DA 2025-06-11
ER

PT J
AU Beeler, JA
   Burghardt, NS
AF Beeler, Jeff A.
   Burghardt, Nesha S.
TI The Rise and Fall of Dopamine: A Two-Stage Model of the Development and
   Entrenchment of Anorexia Nervosa
SO FRONTIERS IN PSYCHIATRY
LA English
DT Article
DE anorexia nervosa; compulsive behavioral disorders; dopamine; chronic
   stress; behavioral plasticity
ID VENTRAL TEGMENTAL AREA; NUCLEUS-ACCUMBENS; FOOD RESTRICTION;
   EATING-DISORDERS; RECEPTOR-BINDING; OREXIN-A; SYNAPTIC-TRANSMISSION;
   MESOLIMBIC DOPAMINE; NEUROTROPHIC FACTOR; METABOLIC SYNDROME
AB Dopamine has long been implicated as a critical neural substrate mediating anorexia nervosa (AN). Despite nearly 50 years of research, the putative direction of change in dopamine function remains unclear and no consensus on the mechanistic role of dopamine in AN has been achieved. We hypothesize two stages in AN- corresponding to initial development and entrenchment- characterized by opposite changes in dopamine. First, caloric restriction, particularly when combined with exercise, triggers an escalating spiral of increasing dopamine that facilitates the behavioral plasticity necessary to establish and reinforce weight-loss behaviors. Second, chronic self-starvation reverses this escalation to reduce or impair dopamine which, in turn, confers behavioral inflexibility and entrenchment of now established AN behaviors. This pattern of enhanced, followed by impaired dopamine might be a common path to many behavioral disorders characterized by reinforcement learning and subsequent behavioral inflexibility. If correct, our hypothesis has significant clinical and research implications for AN and other disorders, such as addiction and obesity.
C1 [Beeler, Jeff A.] CUNY Queens Coll, Dept Psychol, Flushing, NY 11367 USA.
   [Beeler, Jeff A.; Burghardt, Nesha S.] CUNY, Grad Ctr, Psychol Program, New York, NY 10016 USA.
   [Beeler, Jeff A.] CUNY, Grad Ctr, Biol Program, New York, NY 10016 USA.
   [Burghardt, Nesha S.] CUNY Hunter Coll, Dept Psychol, 695 Pk Ave, New York, NY 10021 USA.
C3 City University of New York (CUNY) System; Queens College NY (CUNY);
   City University of New York (CUNY) System; City University of New York
   (CUNY) System; City University of New York (CUNY) System; Hunter College
   (CUNY)
RP Beeler, JA (corresponding author), CUNY Queens Coll, Dept Psychol, Flushing, NY 11367 USA.; Beeler, JA; Burghardt, NS (corresponding author), CUNY, Grad Ctr, Psychol Program, New York, NY 10016 USA.; Beeler, JA (corresponding author), CUNY, Grad Ctr, Biol Program, New York, NY 10016 USA.; Burghardt, NS (corresponding author), CUNY Hunter Coll, Dept Psychol, 695 Pk Ave, New York, NY 10021 USA.
EM jbeeler@qc.cuny.edu; nb844@hunter.cuny.edu
RI Burghardt, Nesha/JTV-4305-2023
FU NIDA [DA046058]; NIMH [R21MH114182]; US National Institute on Minority
   Health and Health Disparities of the NIH [G12MD007599]; PSC-CUNY Awards;
   Professional Staff Congress; City University of New York; Klarman Family
   Foundation Eating Disorders Grant
FX This work was supported by NIDA, DA046058 (JB), NIMH, R21MH114182 (NB),
   US National Institute on Minority Health and Health Disparities of the
   NIH, G12MD007599 (NB), PSC-CUNY Awards jointly funded by the
   Professional Staff Congress and The City University of New York (JB and
   NB) and a Klarman Family Foundation Eating Disorders Grant (JB and NB).
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NR 130
TC 7
Z9 7
U1 0
U2 17
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-0640
J9 FRONT PSYCHIATRY
JI Front. Psychiatry
PD JAN 11
PY 2022
VL 12
AR 799548
DI 10.3389/fpsyt.2021.799548
PG 10
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA YS4NQ
UT WOS:000750656100001
PM 35087433
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Kim, MJ
   Namkung, J
   Chang, JS
   Kim, SJ
   Park, KS
   Kong, ID
AF Kim, Min-Jeong
   Namkung, Jun
   Chang, Jae Seung
   Kim, Soo-Jin
   Park, Kyu-Sang
   Kong, In Deok
TI Leptin regulates the expression of angiopoietin-like 6
SO BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
LA English
DT Article
DE Leptin; ANGPTL6; Liver; Gene expression regulation; Exercise
ID GROWTH-FACTOR; DIABETES-MELLITUS; SERUM-LEVELS; INSULIN-RESISTANCE;
   METABOLIC SYNDROME; GENE-EXPRESSION; ADIPOSE-TISSUE; OBESITY; DIET;
   HEPATOCYTES
AB Angiopoietin-like 6 (ANGPTL6) is a hepatokine that antagonizes obesity and insulin resistance by increasing energy expenditure. Despite its beneficial effects on metabolism, human studies have shown a paradoxical increase in ANGPTL6 level in the serum of patients with metabolic diseases, which has been interpreted as a compensatory upregulation. However, the regulatory mechanism of ANGPTL6 remains unclear. Since upregulation of ANGPTL6 is induced on metabolic stress, we investigated the hepatic expression of ANGPTL6 by leptin, a representative adipokine of obesity. Mice on a high-fat diet showed increased serum leptin levels and hepatic Angptl6 expression, which were attenuated by exercise training. A single leptin injection also induced hepatic ANGPTL6 expression and increased serum ANGPTL6 levels. In an in vitro model using primary hepatocytes, leptin treatment significantly upregulated ANGPTL6 expression at the mRNA and protein levels, as well as the amount of secreted ANGPTL6 protein in conditioned media. Similarly, exercise training on human participants also showed diminished serum levels of leptin and ANGPTL6. Altogether, these results strongly indicated that hepatic ANGPTL6 expression was determined by leptin. (C) 2018 Elsevier Inc. All rights reserved.
C1 [Kim, Min-Jeong] Sungkyunkwan Univ, Sch Med, Kangbuk Samsung Hosp, Inst Med Res, Seoul, South Korea.
   [Kim, Min-Jeong; Kim, Soo-Jin; Park, Kyu-Sang; Kong, In Deok] Yonsei Univ, Wonju Coll Med, Dept Physiol, Wonju, South Korea.
   [Namkung, Jun] Yonsei Univ, Wonju Coll Med, Dept Biochem, Wonju, South Korea.
   [Namkung, Jun; Chang, Jae Seung; Kim, Soo-Jin; Park, Kyu-Sang] Yonsei Univ, Wonju Coll Med, Mitohormesis Res Ctr, Wonju, South Korea.
   [Chang, Jae Seung; Park, Kyu-Sang; Kong, In Deok] Yonsei Univ, Wonju Coll Med, Inst Lifestyle Med, Wonju, South Korea.
C3 Sungkyunkwan University (SKKU); Samsung Medical Center; Yonsei
   University; Yonsei University; Yonsei University; Yonsei University
RP Kong, ID (corresponding author), Yonsei Univ, Wonju Coll Med, Dept Physiol, 20 Ilsan Ro, Wonju 26426, Gangwon Do, South Korea.
EM kong@yonsei.ac.kr
RI Chang, Jae Seung/JED-9976-2023; NAMKUNG, Jun/AAJ-4549-2020
OI Chang, Jae Seung/0000-0002-4047-1128; Namkung, Jun/0000-0003-0515-0860;
   Park, Kyu-Sang/0000-0003-0322-9807
FU Myung-Sun Kim Memorial Foundation
FX We thank to Jihye Kim and Jiyoung Choi for their technical supports.
   This study was supported by a grant from the Myung-Sun Kim Memorial
   Foundation (2017) to In Deok Kong.
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NR 33
TC 13
Z9 15
U1 0
U2 7
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0006-291X
EI 1090-2104
J9 BIOCHEM BIOPH RES CO
JI Biochem. Biophys. Res. Commun.
PD JUL 20
PY 2018
VL 502
IS 3
BP 397
EP 402
DI 10.1016/j.bbrc.2018.05.180
PG 6
WC Biochemistry & Molecular Biology; Biophysics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics
GA GK7LH
UT WOS:000436385200017
PM 29852166
DA 2025-06-11
ER

PT J
AU Nickens, MA
   Long, RC
   Geraci, SA
AF Nickens, Myrna Alexander
   Long, Robert Craig
   Geraci, Stephen A.
TI Cardiovascular Disease in Pregnancy (Women's Health
   Series)
SO SOUTHERN MEDICAL JOURNAL
LA English
DT Review
DE cardiovascular disease; management; mortality; pregnancy; prognosis
ID ACUTE MYOCARDIAL-INFARCTION; CONGENITAL HEART-DISEASE; UNITED-STATES;
   MATERNAL MORTALITY; RISK; POPULATION; COMPLICATIONS; PREVALENCE;
   OUTCOMES
AB Cardiovascular disease is the leading cause of death generally and the most common cause of death during pregnancy in industrialized countries. Improvement in early diagnosis and treatment of congenital heart disease has increased the number of women with such conditions reaching reproductive age. The growing prevalence of diabetes, hypertension, obesity, hyperlipidemia, and metabolic syndrome has concurrently added to the population of pregnant women with acquired heart disease, including coronary artery disease. Physiologic changes occurring during pregnancy can stress a compromised cardiovascular system, resulting in maternal morbidity, mortality, and compromised fetal outcomes. These risks complicate affected women's decisions to become pregnant, their ability to carry a pregnancy to term, and the complexity and risk benefit of cardiovascular treatments delivered during pregnancy. Risk assessment indices assist the obstetrician, cardiologist, and primary care provider in determining the general prognosis of the patient during pregnancy and although imperfect, can aid patients in making informed decisions. Treatments must be selected that ideally benefit the health of both mother and fetus and at a minimum limit risk to the fetus during gestation.
C1 [Nickens, Myrna Alexander] Univ Mississippi, Med Ctr, Dept Med, Div Cardiovasc Dis, Jackson, MS 39216 USA.
   E Tennessee State Univ, Quillen Coll Med, Dept Med, Johnson City, TN 37614 USA.
C3 University of Mississippi Medical Center; University of Mississippi;
   East Tennessee State University
RP Nickens, MA (corresponding author), Univ Mississippi, Med Ctr, Dept Med, Div Cardiovasc Dis, 2500 N State St, Jackson, MS 39216 USA.
EM Mealexander@umc.edu
RI Stephenson, Priscilla/HTN-3124-2023
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NR 47
TC 8
Z9 10
U1 1
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0038-4348
EI 1541-8243
J9 SOUTH MED J
JI South.Med.J.
PD NOV
PY 2013
VL 106
IS 11
BP 624
EP 630
DI 10.1097/SMJ.0000000000000015
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 298VB
UT WOS:000330351500008
PM 24192594
DA 2025-06-11
ER

PT J
AU Ntalouka, F
   Tsirivakou, A
AF Ntalouka, Foteini
   Tsirivakou, Athina
TI Morus alba: natural and valuable effects in weight loss
   management
SO FRONTIERS IN CLINICAL DIABETES AND HEALTHCARE
LA English
DT Review
DE Morus alba; white mulberry; weight loss; diabesity;
   mulberry's safety
ID MULBERRY LEAF EXTRACT; POSTPRANDIAL GLUCOSE RESPONSE; HIGH-FAT-DIET;
   INSULIN-RESISTANCE; PANCREATIC LIPASE; OXIDATIVE STRESS; METABOLIC
   SYNDROME; OBESITY; 1-DEOXYNOJIRIMYCIN; L.
AB Overweight and obesity are conditions associated with serious comorbidities, such as diabetes and cardiovascular disease. Prevalence of excessive fat accumulation is increasing worldwide, and thus the need for efficient and sustainable weight loss regimes has become a major issue in clinical practice. Despite the important advances in the development of anti-obesity medications (AOM), their side effects, cost, and accessibility, are limiting factors for their routine use. Conversely, the studies of medicinal plants for weight management holds strong promise as a growing area of research. This review consolidates the representative evidence about the beneficial impacts of Morus alba on weight management and associated metabolic parameters, encompassing: inhibition of digestive enzymes, and thus contribution to the energy deficit required for weight loss, improvements in glucose and lipid metabolism, and attenuation of adiposity. Findings from in vitro, in vivo, and clinical investigations reviewed in the paper, demonstrate that white mulberry extracts have the potency to supplement efficiently and safely a healthy weight management approach.
C1 [Ntalouka, Foteini; Tsirivakou, Athina] Herbalist PC, Dept Res & Dev, Athens, Greece.
RP Ntalouka, F (corresponding author), Herbalist PC, Dept Res & Dev, Athens, Greece.
EM fntalouka@gmail.com
FU Herbalist P.C
FX The authors declare that financial support was received by Herbalist
   P.C. only for the publication of this article. Article processing fees
   were funded by Herbalist P.C.. The funder was not involved in the study
   design, collection, analysis, interpretation of data, the writing of
   this article, or the decision to submit it for publication.
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NR 127
TC 0
Z9 0
U1 2
U2 2
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 2673-6616
J9 FRONT CLIN DIABETES
JI Front. Clin. Diabet. Healthc.
PD OCT 25
PY 2024
VL 5
AR 1395688
DI 10.3389/fcdhc.2024.1395688
PG 17
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA M3J4N
UT WOS:001356536400001
PM 39544693
OA gold
DA 2025-06-11
ER

PT J
AU Soto-Covasich, J
   Reyes-Farias, M
   Torres, RF
   Vasquez, K
   Duarte, L
   Quezada, J
   Jimenez, P
   Pino, MT
   Garcia-Nannig, L
   Mercado, L
   Garcia-Diaz, DF
AF Soto-Covasich, J.
   Reyes-Farias, M.
   Torres, R. F.
   Vasquez, K.
   Duarte, L.
   Quezada, J.
   Jimenez, P.
   Pino, M. T.
   Garcia-Nannig, L.
   Mercado, L.
   Garcia-Diaz, D. F.
TI A polyphenol-rich Calafate (Berberis microphylla) extract rescues
   glucose tolerance in mice fed with cafeteria diet
SO JOURNAL OF FUNCTIONAL FOODS
LA English
DT Article
DE Obesity; Adipose tissue; Inflammation; Glucose tolerance; Natural
   product
ID CHRONIC-MILD STRESS; HIGH-FAT DIET; INSULIN-RESISTANCE; INDUCED OBESITY;
   PATHOGENIC INTERACTION; METABOLIC SYNDROME; ADIPOSE-TISSUE;
   INFLAMMATION; ADIPOCYTES; MODEL
AB The establishment of a chronic inflammatory state in the adipose tissue contributes to obesity-associated insulin resistance. Hence, disrupting the inflammatory response elicited by obesity remains a relevant target to tackle the modern-world pandemic. We evaluated the anti-inflammatory and insulin-sensitizing effect of Calafate (Berberis microphylla) by producing and characterizing a polyphenol-pure Calafate extract (PPCE). C57BL/6 mice fed with cafeteria diet for 14 weeks were administered PPCE (50 mg/Kg/day) for 4 weeks. PPCE administration rescued glucose tolerance and insulin-elicited AKT phosphorylation in white adipose tissue of diet-induced insulin-resistant mice. Furthermore, the cafeteria diet-induced expression of TNF-alpha and F4/80 was attenuated by PPCE administration, suggesting that PPCE rescues insulin sensibility by ameliorating the obesity-associated inflammatory state. Altogether, our data shows that Calafate represents a natural source of polyphenols with glucose tolerance-improving properties in vivo, suggesting a potential use of PPCE as a complementary tool against insulin resistance.
C1 [Soto-Covasich, J.] Pontificia Univ Catolica Valparaiso, Programa Doctorado Biotecnol, Univ Tecn Federico Santa Maria, Valparaiso, Chile.
   [Reyes-Farias, M.; Vasquez, K.; Duarte, L.; Quezada, J.; Jimenez, P.; Garcia-Diaz, D. F.] Univ Chile, Fac Med, Dept Nutr, Independencia 1027, Santiago, Chile.
   [Torres, R. F.] Fdn Cultura Cient, Lab Biol, Valdivia, Chile.
   [Torres, R. F.] UCSC, Fac Med, Dept Ciencias Basicas, Concepcion, Chile.
   [Pino, M. T.] Inst Invest Agr, Santiago, Chile.
   [Garcia-Nannig, L.] Univ Chile, Adv Ctr Chron Dis ACCDiS, Santiago, Chile.
   [Mercado, L.] Pontificia Univ Catolica Valparaiso, Inst Biol, Lab Inmunol, Valparaiso, Chile.
C3 Universidad Tecnica Federico Santa Maria; Pontificia Universidad
   Catolica de Valparaiso; Universidad de Chile; Universidad Catolica de la
   Santisima Concepcion; Universidad de Chile; Pontificia Universidad
   Catolica de Valparaiso
RP Garcia-Diaz, DF (corresponding author), Univ Chile, Fac Med, Dept Nutr, Independencia 1027, Santiago, Chile.
EM dgarcia@med.uchile.cl
RI Garcia, Diego/AGH-4056-2022; Reyes Farias, Marjorie/AGP-5221-2022;
   Jiménez, Paula/H-3136-2018; Duarte, Lissette/AAW-9831-2020
OI Garcia-Diaz, Diego/0000-0002-7551-0553; Mercado,
   Luis/0000-0003-3883-5188; Torres, Rodrigo/0000-0002-4328-2920;
   Reyes-Farias, Marjorie/0000-0001-9179-7251
FU CONICYT Scholarship (Chile) [21120219]; FONDECYT Project (CONICYT,
   Chile) [11110219]
FX Soto Covasich J has a CONICYT Scholarship (Chile, 21120219) for his
   graduate studies at the PhD program in Biotechnology, Universidad
   Tecnica Federico Santa Maria-Pontificia Universidad Catolica de
   Valparaiso. This work was supported by FONDECYT Project 11110219
   (CONICYT, Chile). Finally, authors thank the technical assistance of
   Francisca Echeverria (Department of Nutrition, University of Chile).
CR Anhê FF, 2017, MOL METAB, V6, P1563, DOI 10.1016/j.molmet.2017.10.003
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NR 43
TC 16
Z9 16
U1 0
U2 11
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1756-4646
EI 2214-9414
J9 J FUNCT FOODS
JI J. Funct. Food.
PD APR
PY 2020
VL 67
AR 103856
DI 10.1016/j.jff.2020.103856
PG 9
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA LD0RC
UT WOS:000525739700025
OA gold
DA 2025-06-11
ER

PT J
AU Baltzis, D
   Meimeti, E
   Grammatikopoulou, MG
   Roustit, M
   Mavrogonatou, E
   Kletsas, D
   Efraimidou, S
   Manes, C
   Nikolouzakis, TK
   Tsiaoussis, J
   Tsatsakis, AM
   Spandidos, DA
   Trakatelli, CM
   Drakoulis, N
AF Baltzis, Dimitrios
   Meimeti, Evangelia
   Grammatikopoulou, Maria G.
   Roustit, Matthieu
   Mavrogonatou, Eleni
   Kletsas, Dimitris
   Efraimidou, Smaragda
   Manes, Christos
   Nikolouzakis, Taxiarchis K.
   Tsiaoussis, John
   Tsatsakis, Aristides M.
   Spandidos, Demetrios A.
   Trakatelli, Christina-Maria
   Drakoulis, Nikolaos
TI Assessment of telomerase activity in leukocytes of type 2 diabetes
   mellitus patients having or not foot ulcer: Possible correlation with
   other clinical parameters
SO EXPERIMENTAL AND THERAPEUTIC MEDICINE
LA English
DT Article
DE diabetic peripheral neuropathy; neuropathy disability score; oxidative
   damage; telomere-diabetes
ID OXIDATIVE STRESS; MYOCARDIAL-ISCHEMIA; INSULIN-RESISTANCE; METABOLIC
   SYNDROME; HUMAN FIBROBLASTS; LENGTH; CELLS; RISK; ASSOCIATION;
   SENESCENCE
AB Telomerase is the enzyme that maintains telomere length by adding telomeric repeats after each cell division. Numerous metabolic factors such as obesity, insulin resistance or physical inactivity have been associated with shortened telomeres. In the present study, we assessed telomerase activity in diabetic patients having or not foot ulcer. A total of 90 adult patients with type 2 diabetes mellitus (T2DM) were studied. Patients were allocated into two groups according to the absence or presence of active foot ulcers as follows: on-ulcer group (N=58) and ulcer group (N=32). Our data revealed that the patients with diabetic ulcers had significantly greater waist circumference and neuropathy disability score, while exhibiting lower telomerase activity, indicating the possible existence of a common clinical profile among ulcer-bearing diabetic patients. Validation of our findings by extending the study in larger patient groups may contribute to the understanding of T2DM pathophysiology and its main clinical implications.
C1 [Baltzis, Dimitrios; Manes, Christos] Papageorgiou Gen Hosp, Ctr Diabet, Thessaloniki 56403, Greece.
   [Baltzis, Dimitrios; Trakatelli, Christina-Maria] Papageorgiou Gen Hosp, Dept Internal Med 3, Thessaloniki 56403, Greece.
   [Meimeti, Evangelia; Drakoulis, Nikolaos] Univ Athens, Sch Hlth Sci, Res Grp Clin Pharmacol & Pharmacogen, Fac Pharm, Athens 15771, Greece.
   [Grammatikopoulou, Maria G.] Alexander Technol Educ Inst, Dept Nutr & Dietet, Thessaloniki 57400, Greece.
   [Roustit, Matthieu] La Tronche Univ Grenoble Alpes, Univ Grenoble Alpes, HP2 Lab, Grenoble, France.
   [Mavrogonatou, Eleni; Kletsas, Dimitris] Natl Ctr Sci Res Demokritos, Inst Biosci & Applicat, Lab Cell Proliferat & Ageing, Athens 15341, Greece.
   [Efraimidou, Smaragda] Papageorgiou Gen Hosp, Dept Hematol, Thessaloniki 56403, Greece.
   [Nikolouzakis, Taxiarchis K.; Tsiaoussis, John] Univ Crete, Sch Med, Lab Anat Histol Embryol, Iraklion 71003, Greece.
   [Tsatsakis, Aristides M.] Univ Crete, Sch Med, Dept Forens Sci & Toxicol, Iraklion 71003, Greece.
   [Spandidos, Demetrios A.] Univ Crete, Sch Med, Lab Clin Virol, Iraklion 71003, Greece.
C3 Papageorgiou Hospital; Papageorgiou Hospital; National & Kapodistrian
   University of Athens; International Hellenic University; Communaute
   Universite Grenoble Alpes; Universite Grenoble Alpes (UGA); Institut
   National de la Sante et de la Recherche Medicale (Inserm); National
   Centre of Scientific Research "Demokritos"; Papageorgiou Hospital;
   University of Crete; University of Crete; University of Crete
RP Drakoulis, N (corresponding author), Univ Athens, Sch Hlth Sci, Res Grp Clin Pharmacol & Pharmacogen, Fac Pharm, Athens 15771, Greece.
EM drakoulis@pharm.uoa.gr
RI Kletsas, Dimitris/F-6953-2010; Mavrogonatou, Eleni/N-1923-2019; Roustit,
   Matthieu/M-6927-2014; TSATSAKIS, ARISTIDIS/H-2890-2013
OI Kletsas, Dimitris/0000-0002-9828-3963; Trakatelli,
   Christina/0000-0001-8110-938X; Mavrogonatou, Eleni/0000-0003-0982-6426;
   TSATSAKIS, ARISTIDIS/0000-0003-3824-2462; Spandidos,
   Demetrios/0000-0002-1146-931X
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NR 40
TC 17
Z9 18
U1 0
U2 1
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1792-0981
EI 1792-1015
J9 EXP THER MED
JI Exp. Ther. Med.
PD APR
PY 2018
VL 15
IS 4
BP 3420
EP 3424
DI 10.3892/etm.2018.5798
PG 5
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA GB3GV
UT WOS:000428945200036
PM 29616085
OA Green Submitted, gold, Green Published
DA 2025-06-11
ER

PT J
AU Krishnaveni, GV
   Yajnik, CS
AF Krishnaveni, G. V.
   Yajnik, C. S.
TI Developmental origins of diabetes-an Indian perspective
SO EUROPEAN JOURNAL OF CLINICAL NUTRITION
LA English
DT Review
ID PUNE MATERNAL NUTRITION; BODY-MASS INDEX; INSULIN-RESISTANCE;
   BIRTH-WEIGHT; CARDIOVASCULAR RISK; GLUCOSE-TOLERANCE; FETAL-GROWTH;
   NEONATAL ANTHROPOMETRY; FOLATE CONCENTRATIONS; METABOLIC SYNDROME
AB The developmental origins of health disease (DOHaD) hypothesis proposes that altered environmental influences (nutrition, metabolism, pollutants, stress and so on) during critical stages of fetal growth predisposes individuals to diabetes and other non-communicable disease in later life. This phenomenon is thought to reflect permanent effects ('programming') of unbalanced fetal development on physiological systems. Intrauterine programming may underlie the characteristic Indian 'thin-fat' phenotype and the current unprecedented epidemic of diabetes on the backdrop of multigenerational maternal undernutrition in the country. India has been at the forefront of the DOHaD research for over two decades. Both retrospective and prospective birth cohorts in India provide evidence for the role of impaired early-life nutrition on the later diabetes risk. These studies show that in a transitioning country such as India, maternal undernutrition (of micronutrients) and overnutrition (gestational diabetes) co-exist, and expose the offspring to disease risk through multiple pathways. Currently, the Indian scientists are embarking on complex mechanistic and intervention studies to find solutions for the diabetes susceptibility of this population. However, a few unresolved issues in this context warrant continued research and a cautious approach.
C1 [Krishnaveni, G. V.] CSI Holdsworth Mem Hosp, Epidemiol Res Unit, Mysore 570021, Karnataka, India.
   [Yajnik, C. S.] King Edward Mem Hosp & Res Ctr, Diabet Unit, Pune, Maharashtra, India.
RP Krishnaveni, GV (corresponding author), CSI Holdsworth Mem Hosp, Epidemiol Res Unit, Mysore 570021, Karnataka, India.
EM gv.krishnaveni@gmail.com
OI Krishnaveni, Ghattu V/0000-0002-6532-8272
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NR 44
TC 24
Z9 25
U1 1
U2 10
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0954-3007
EI 1476-5640
J9 EUR J CLIN NUTR
JI Eur. J. Clin. Nutr.
PD JUL
PY 2017
VL 71
IS 7
BP 865
EP 869
DI 10.1038/ejcn.2017.87
PG 5
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA FA1DH
UT WOS:000405178900012
PM 28537579
DA 2025-06-11
ER

PT J
AU Abd El-Wahab, HMF
   Mohamed, MA
   El Sayed, HH
   Bauomy, AE
AF Abd El-Wahab, Hanan M. F.
   Mohamed, Mona A.
   El Sayed, Hanaa H.
   Bauomy, Alshimaa E.
TI Modulatory effects of rice bran and its oil on lipid metabolism in
   insulin resistance rats
SO JOURNAL OF FOOD BIOCHEMISTRY
LA English
DT Article
DE fructose; HMG-CoA reductase; insulin receptor; metabolic syndrome; rice
   bran
ID HMG-COA REDUCTASE; KINASE C-DELTA; HIGH-FAT; DEFENSE SYSTEM; OXIDATIVE
   STRESS; SKELETAL-MUSCLE; GENE-EXPRESSION; FRUCTOSE; DIET;
   PHOSPHORYLATION
AB The study was designed to evaluate the effects of rice bran (RB) or its oil (RBO) on lipid metabolism, hepatic insulin receptor substrate-1 (IRS-1) and hepatic expression of 3-hydroxy-3methylglutaryl-Co A (HMG-CoA) reductase in rats fed high-fructose diet (HFD). Rats were divided into four groups: Group 1, animals received standard diet as control, while groups 2, 3 and 4 were fed on a HFD. Groups 3 and 4 animals fed HFD containing RB (5%) instead of cellulose and RBO (10%) instead of corn oil, respectively for 5 weeks. Fructose feeding to rats caused significant elevations in plasma glucose, serum insulin, and lipid profile, while serum total antioxidant capacity was significantly reduced compared to control. Hepatic concentration of IRS-1 was decreased while malondialdehyde (MDA) and HMG-CoA reductase mRNA were elevated compared to control group. Addition of RB or RBO to fructose fed rats alleviated the hazardous effects of fructose.
C1 [Abd El-Wahab, Hanan M. F.] Ain Shams Univ, Womens Coll Art Sci & Educ, Dept Biochem & Nutr, Cairo, Egypt.
   [Mohamed, Mona A.] Al Azhar Univ, Fac Sci, Dept Chem, Div Biochem, PO 11754, Cairo, Egypt.
   [El Sayed, Hanaa H.] Natl Inst Nutr, Dept Nutr Biochem & Metab, Cairo, Egypt.
   [Bauomy, Alshimaa E.] Al Azhar Univ, Sci, Cairo, Egypt.
   [Bauomy, Alshimaa E.] Menoufia Univ, Biochem & Analyt Chem, Cairo, Egypt.
C3 Egyptian Knowledge Bank (EKB); Ain Shams University; Egyptian Knowledge
   Bank (EKB); Al Azhar University; Egyptian Knowledge Bank (EKB); Al Azhar
   University; Egyptian Knowledge Bank (EKB); Menofia University
RP Mohamed, MA (corresponding author), Al Azhar Univ, Fac Sci, Dept Chem, Div Biochem, PO 11754, Cairo, Egypt.
EM mabdelgelel@gmail.com
RI mohamed, mona/F-5840-2016; El-Wahab, Hanan/H-9523-2019
OI Abdel Wahab, Hanan MF/0000-0003-4965-2117
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NR 67
TC 9
Z9 9
U1 0
U2 8
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0145-8884
EI 1745-4514
J9 J FOOD BIOCHEM
JI J. Food Biochem.
PD FEB
PY 2017
VL 41
IS 1
AR e12318
DI 10.1111/jfbc.12318
PG 8
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA EP3LO
UT WOS:000397284000014
OA gold
DA 2025-06-11
ER

PT J
AU McPherson, NO
   Owens, JA
   Fullston, T
   Lane, M
AF McPherson, Nicole O.
   Owens, Julie A.
   Fullston, Tod
   Lane, Michelle
TI Preconception diet or exercise intervention in obese fathers normalizes
   sperm microRNA profile and metabolic syndrome in female offspring
SO AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
LA English
DT Article
DE fertility; infertility; paternal programming; interventions; obesity
ID BODY-MASS INDEX; HIGH-FAT DIET; TRANSGENERATIONAL INHERITANCE;
   REPRODUCTIVE HEALTH; INSULIN-RESISTANCE; PATERNAL OBESITY;
   ADIPOSE-TISSUE; WEIGHT-LOSS; MICE; MOUSE
AB Obesity and type 2 diabetes are increasingly prevalent across all demographics. Paternal obesity in humans and rodents can program obesity and impair insulin sensitivity in female offspring. It remains to be determined whether these perturbed offspring phenotypes can be improved through targeted lifestyle interventions in the obese father. Using a mouse model, we demonstrate that diet or exercise interventions for 8 wk (2 rounds of spermatogenesis) in obese founder males restores insulin sensitivity and normalized adiposity in female offspring. Founder diet and/or exercise also normalizes abundance of X-linked sperm microRNAs that target genes regulating cell cycle and apoptosis, pathways central to oocyte and early embryogenesis. Additionally, obesity-associated comorbidities, including inflammation, glucose intolerance, stress, and hypercholesterolemia, were good predictors for sperm microRNA abundance and offspring phenotypes. Interventions aimed at improving paternal metabolic health during specific windows prior to conception can partially normalize aberrant epigenetic signals in sperm and improve the metabolic health of female offspring.
C1 [McPherson, Nicole O.; Owens, Julie A.; Fullston, Tod; Lane, Michelle] Univ Adelaide, Sch Pediat & Reprod Hlth, Discipline Obstet & Gynaecol, Robinson Res Inst, Adelaide, SA 5005, Australia.
   [McPherson, Nicole O.; Lane, Michelle] Univ Adelaide, Freemasons Ctr Mens Hlth, Adelaide, SA 5005, Australia.
   [Lane, Michelle] Monash IVF Grp, Melbourne, Australia.
C3 University of Adelaide; Robinson Research Institute; University of
   Adelaide
RP McPherson, NO (corresponding author), Univ Adelaide, Sch Pediat & Reprod Hlth, Discipline Obstet & Gynaecol, Med Sch South, Level 3, Adelaide, SA 5005, Australia.
EM nicole.mcpherson@adelaide.edu.au
RI Owens, Julie/C-9744-2009
OI Owens, Julie/0000-0002-7498-1353; McPherson, Nicole/0000-0002-3492-9403
FU National Health and Medical Research Council (NHMRC)
FX This research is supported by a National Health and Medical Research
   Council (NHMRC) grant awarded to M. Lane. M. Lane is a recipient of an
   NHMRC Senior Research Fellowship, and N. O. McPherson is a recipient of
   an NHMRC Early Career Fellowship.
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NR 70
TC 150
Z9 160
U1 2
U2 42
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0193-1849
EI 1522-1555
J9 AM J PHYSIOL-ENDOC M
JI Am. J. Physiol.-Endocrinol. Metab.
PD MAY 1
PY 2015
VL 308
IS 9
BP E805
EP E821
DI 10.1152/ajpendo.00013.2015
PG 17
WC Endocrinology & Metabolism; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Physiology
GA CH3SX
UT WOS:000353951700010
PM 25690453
DA 2025-06-11
ER

PT J
AU Hanks, LJ
   Casazza, K
   Alvarez, JA
   Fernandez, JR
AF Hanks, Lynae J.
   Casazza, Krista
   Alvarez, Jessica A.
   Fernandez, Jose R.
TI Does Fat Fuel the Fire: Independent and Interactive Effects of Genetic,
   Physiological, and Environmental Factors on Variations in Fat Deposition
   and Distribution across Populations
SO JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
LA English
DT Article
ID INSULIN-RESISTANCE; METABOLIC SYNDROME; FOREARM FRACTURES;
   ADIPOSE-TISSUE; CARDIOVASCULAR RISK; OVERWEIGHT CHILDREN; OXIDATIVE
   STRESS; AFRICAN-AMERICAN; PUBERTAL CHANGES; VISCERAL FAT
AB Markers of inflammation (MOI) have been reported to influence bone health in adults, with reports of inverse associations. Adipose has also been linked to bone. In children, the interrelationships are unclear. The objective of this study was to evaluate the relationship between MOI (i.e. CRP, TNFR2, IL-6) and bone mineral content (BMC) and determine the contribution of fat deposition/distribution in children. Forty-nine children (59% male) 7-12 y participated. Body composition was evaluated by DXA, and MOI and insulin sensitivity (S(I)) were obtained during an IVGTT. Multiple linear regression was used for analyses. TNFR2 was inversely associated with BMC. In boys, TNFR2 was inversely associated with BMC, and in girls IL-6 was inversely associated with BMC, and total and percent fat influenced the relationships. Our results suggest a potential inhibitory role of inflammation on bone as well as a negative impact of adiposity. Future investigations are warranted to further investigate these relationships.
C1 [Hanks, Lynae J.; Casazza, Krista; Alvarez, Jessica A.; Fernandez, Jose R.] Univ Alabama, Dept Nutr Sci, Birmingham, AL 35294 USA.
   [Hanks, Lynae J.; Casazza, Krista; Alvarez, Jessica A.; Fernandez, Jose R.] Univ Alabama, Clin Nutr Res Ctr, Birmingham, AL 35294 USA.
   [Fernandez, Jose R.] Univ Alabama, Dept Biostat, Sect Stat Genet, Birmingham, AL 35294 USA.
C3 University of Alabama System; University of Alabama Birmingham;
   University of Alabama System; University of Alabama Birmingham;
   University of Alabama System; University of Alabama Birmingham
RP Hanks, LJ (corresponding author), Univ Alabama, Dept Nutr Sci, Birmingham, AL 35294 USA.
EM hankslj@uab.edu
FU National Institutes of Health [R01 DK067426-01, M01 RR00032,
   5K99DK83333]; American Heart Association (Greater Southeast Affiliate); 
   [K99/R00]
FX This work has been supported in part by National Institutes of Health
   grants: R01 DK067426-01, M01 RR00032. K.C. was supported by K99/R00
   Transition to Independence Award (NIH 5K99DK83333). J.A.A. was supported
   by a pre-doctoral grant from the American Heart Association (Greater
   Southeast Affiliate). We are grateful to Maryellen Williams, Betty
   Darnell and the UAB Participant & Clinical Interactions Resources for
   their assistance with data collection. Additionally, none of the authors
   or these individuals has potential conflicts of interest.
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NR 41
TC 6
Z9 6
U1 0
U2 6
PU FREUND PUBLISHING HOUSE LTD
PI TEL AVIV
PA PO BOX 35010, TEL AVIV 61350, ISRAEL
SN 0334-018X
J9 J PEDIATR ENDOCR MET
JI J. Pediatr. Endocrinol. Metab.
PD DEC
PY 2010
VL 23
IS 12
BP 1233
EP 1244
DI 10.1515/jpem.2010.197
PG 12
WC Endocrinology & Metabolism; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Pediatrics
GA 712YC
UT WOS:000286701200005
PM 21714457
OA Green Submitted, Green Accepted
DA 2025-06-11
ER

PT J
AU Heikkala, E
   Oura, P
   Paananen, M
   Ho, EM
   Ferreira, P
   Tanguay-Sabourin, C
   Karppinen, J
AF Heikkala, Eveliina
   Oura, Petteri
   Paananen, Markus
   Ho, Emma
   Ferreira, Paulo
   Tanguay-Sabourin, Christophe
   Karppinen, Jaro
TI Chronic disease clusters are associated with prolonged, bothersome, and
   multisite musculoskeletal pain: a population-based study on Northern
   Finns
SO ANNALS OF MEDICINE
LA English
DT Article
DE Musculoskeletal pain; pain severity; chronic diseases; cohort study
ID LOW-BACK-PAIN; METABOLIC SYNDROME; RHEUMATOID-ARTHRITIS; RISK-FACTORS;
   DEPRESSION; MULTIMORBIDITY; ANXIETY; OSTEOARTHRITIS; SYMPTOMS; HEALTH
AB Background Chronic diseases often accumulate with musculoskeletal (MSK) pain. However, less evidence is available on idiosyncratic patterns of chronic diseases and their relationships with the severity of MSK pain in general MSK pain populations. Material and methods Questionnaire-based data on physician-diagnosed chronic diseases, MSK pain and its dimensions (frequency, intensity, bothersomeness, and the number of pain sites), and confounders were collected from the Northern Finland Birth Cohort 1966 at the age of 46. Latent Class Analysis (LCA) was used to identify chronic disease clusters among individuals who reported any MSK pain within the previous year (n = 6105). The associations between chronic disease clusters, pain dimensions, and severe MSK pain, which was defined as prolonged (over 30 d within the preceding year), bothersome (Numerical Rating Scale >5), and multisite (two or more pain sites) pain, were analyzed using logistic regression and general linear regression models, adjusted for sex and educational level (n for the full sample = 4768). Results LCA resulted in three clusters: Metabolic (10.8% of the full sample), Psychiatric (2.9%), and Relatively Healthy (86.3%). Compared to the Relatively Healthy cluster, the Metabolic and Psychiatric clusters had higher odds for daily pain and higher mean pain intensity, bothersomeness, and the number of pain sites. Similarly, the odds for severe MSK pain were up to 75% (95% confidence interval: 44%-113%) and 155% (81%-259%) higher in the Metabolic and Psychiatric clusters, respectively, after adjustments for sex and educational level. Conclusions Distinct patterns of chronic disease accumulation can be identified in the general MSK pain population. It seems that mental and metabolic health are at interplay with severe MSK pain. These findings suggest a potential need to screen for psychiatric and metabolic entities of health when treating working-aged people with MSK pain. Key messages This large study on middle-aged people with musculoskeletal pain aimed to examine the idiosyncratic patterns of chronic diseases and their relationships with the severity of musculoskeletal pain. Latent class cluster analysis identified three chronic disease clusters: Psychiatric, Metabolic, and Relatively Healthy. People with accumulated mental (Psychiatric cluster) or metabolic diseases (Metabolic cluster) experienced more severe pain than people who were relatively healthy (Relatively Healthy cluster). These findings suggest a potential need to screen for psychiatric and metabolic entities of health when treating working-aged people with MSK pain.
C1 [Heikkala, Eveliina; Oura, Petteri; Paananen, Markus; Karppinen, Jaro] Univ Oulu, Res Unit Populat Hlth, Oulu, Finland.
   [Heikkala, Eveliina; Oura, Petteri; Paananen, Markus; Karppinen, Jaro] Univ Oulu, Med Res Ctr Oulu, Oulu, Finland.
   [Heikkala, Eveliina; Oura, Petteri; Paananen, Markus; Karppinen, Jaro] Oulu Univ Hosp, Oulu, Finland.
   [Heikkala, Eveliina] Rovaniemi Hlth Ctr, Rovaniemi, Finland.
   [Paananen, Markus] Western Uusimaa Wellbeing Serv Cty, Social & Hlth Care Serv, Espoo, Finland.
   [Ho, Emma; Ferreira, Paulo] Univ Sydney, Charles Perkins Ctr, Sch Hlth Sci, Sydney Musculoskeletal Hlth, Sydney, Australia.
   [Ho, Emma] Univ Sydney, Kolling Inst, Sch Hlth Sci, Sydney Musculoskeletal Hlth, Sydney, Australia.
   [Tanguay-Sabourin, Christophe] McGill Univ, Alan Edwards Pain Ctr Res Pain, Montreal, PQ, Canada.
   [Tanguay-Sabourin, Christophe] Univ Montreal, Fac Med, Montreal, PQ, Canada.
   [Karppinen, Jaro] Rehabil Serv South Karel Social & Hlth Care Dist, Lappeenranta, Finland.
   [Heikkala, Eveliina] Univ Oulu, Res Unit Populat Hlth, Oulu 90014, Finland.
C3 University of Oulu; University of Oulu; University of Oulu; University
   of Sydney; University of Sydney; Kolling Institute of Medical Research;
   McGill University; Universite de Montreal; University of Oulu
RP Heikkala, E (corresponding author), Univ Oulu, Res Unit Populat Hlth, Oulu 90014, Finland.
RI Heikkala, Eveliina/ISA-0751-2023; Ho, Emma/ABD-7424-2020
OI Karppinen, Jaro/0000-0002-2158-6042; Ho, Emma
   Kwan-Yee/0000-0002-2479-0081; Heikkala, Eveliina/0000-0001-7156-491X
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NR 72
TC 4
Z9 4
U1 3
U2 18
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0785-3890
EI 1365-2060
J9 ANN MED
JI Ann. Med.
PD DEC 31
PY 2023
VL 55
IS 1
BP 592
EP 602
DI 10.1080/07853890.2023.2177723
PG 11
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 8X5NA
UT WOS:000932058900001
PM 36773018
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Mahmoodi, Z
   Ghaleno, SR
AF Mahmoodi, Zohreh
   Ghaleno, Saeedeh Rashki
TI Comparison of serum ferritin levels between diabetic and non-diabetic
   acute myocardial infarction patients
SO TRACE ELEMENTS AND ELECTROLYTES
LA English
DT Article
DE serum ferritin level; diabetes; acute myocardial infarction
ID RISK-FACTORS; IRON STORES; BODY IRON; INSULIN-RESISTANCE; METABOLIC
   SYNDROME; OXIDATIVE STRESS; HEART-DISEASE; RED MEAT; ASSOCIATION;
   METAANALYSIS
AB Background: As diabetes is an important risk factor for myocardial infarction (MI), the present study investigates the relationship between coronary artery disease (CAD) and ferritin levels in diabetic and non -diabetic Iranian patients. Materials and methods: This is a descriptive -analytical prospective study among MI patients in cardiac care units (CCU) in 2020. The eligible patients admitted from January 1, 2020 to January 1, 2021 participated according to the inclusion criteria. The ferritin level was measured using ELISA. Data were analyzed via SPSS 22. Results: Out of 135 MI patients, 55 (40.74%) were in the diabetic group, and 80 (59.25%) were non -diabetic. The diabetics' serum ferritin (122.56 ng/mL) was significantly higher than that of the control group (92.67 ng/mL) (p = 0.02). However, the other laboratory findings were not significantly different between the two groups. Conclusion: Higher levels of ferritin were associated with diabetes mellitus in patients with acute MI. The exact mechanism of such a relationship must be examined in further prospective studies.
C1 [Mahmoodi, Zohreh; Ghaleno, Saeedeh Rashki] Zabol Univ Med Sci, Cardiol Dept, Zabol, Iran.
   [Ghaleno, Saeedeh Rashki] Zabol Univ Med Sci, Cardiol Dept, Cardiol, Zabol, Iran.
RP Ghaleno, SR (corresponding author), Zabol Univ Med Sci, Cardiol Dept, Cardiol, Zabol, Iran.
EM 30stana@gmail.com
RI Mahmoodi, zohre/V-6047-2017
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Z9 0
U1 0
U2 1
PU DUSTRI-VERLAG DR KARL FEISTLE
PI DEISENHOFEN-MUENCHEN
PA BAHNHOFSTRASSE 9 POSTFACH 49, D-82032 DEISENHOFEN-MUENCHEN, GERMANY
SN 0946-2104
J9 TRACE ELEM ELECTROLY
JI Trace Elem. Electrolytes
PY 2024
VL 41
IS 1-2
BP 16
EP 22
DI 10.5414/TE500055
PG 7
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA MR6S3
UT WOS:001195404900001
DA 2025-06-11
ER

PT J
AU Huang, WW
   Shen, BY
   Li, XM
   Zhang, TC
   Zhou, X
AF Huang, Wenwu
   Shen, Boyuan
   Li, Xiumei
   Zhang, Tongcun
   Zhou, Xiang
TI Benefits of Combining Sonchus brachyotus DC. Extracts and
   Synbiotics in Alleviating Non-Alcoholic Fatty Liver Disease
SO FOODS
LA English
DT Review
DE NAFLD; synbiotics; gut microbiota; Sonchus brachyotus DC. extracts
ID INFLAMMATORY-BOWEL-DISEASE; TISSUE INSULIN-RESISTANCE; DOUBLE-BLIND;
   VITAMIN-E; HEPATIC STEATOSIS; OXIDATIVE STRESS; BACTERIAL TRANSLOCATION;
   METABOLIC SYNDROME; GUT MICROBIOTA; LEAN PATIENTS
AB Non-alcoholic fatty liver disease, commonly abbreviated to NAFLD, is a pervasive ailment within the digestive system, exhibiting a rising prevalence, and impacting individuals at increasingly younger ages. Those afflicted by NAFLD face a heightened vulnerability to the onset of profound liver fibrosis, cardiovascular complications, and malignancies. Currently, NAFLD poses a significant threat to human health, and there is no approved therapeutic treatment for it. Recent studies have shown that synbiotics, which regulate intestinal microecology, can positively impact glucolipid metabolism, and improve NAFLD-related indicators. Sonchus brachyotus DC., a Chinese herb, exhibits hepatoprotective and potent antioxidant properties, suggesting its potential therapeutic use in NAFLD. Our preclinical animal model investigation suggests that the synergy between Sonchus brachyotus DC. extracts and synbiotics is significantly more effective in preventing and treating NAFLD, compared to the isolated use of either component. As a result, this combination holds the potential to introduce a fresh and encouraging therapeutic approach to addressing NAFLD.
C1 [Huang, Wenwu; Shen, Boyuan; Zhang, Tongcun; Zhou, Xiang] Wuhan Univ Sci & Technol, Coll Life Sci & Hlth, Wuhan 430065, Peoples R China.
   [Li, Xiumei] Inst Feed Res CAAS, Minist Agr & Rural Affairs, Key Lab Feed Biotechnol, Beijing 100000, Peoples R China.
C3 Wuhan University of Science & Technology; Ministry of Agriculture &
   Rural Affairs
RP Zhou, X (corresponding author), Wuhan Univ Sci & Technol, Coll Life Sci & Hlth, Wuhan 430065, Peoples R China.
EM wenwu@wust.edu.cn; shenboyuan07@163.com; lixiumei@caas.cn;
   zhangtongcun@wust.edu.cn; zhouxiang@wust.edu.cn
RI WEN, HAO/KZV-0977-2024
FU National Key Research and Development Program of China [2017YFD0400300]
FX This research was funded a grant from National Key Research and
   Development Program of China (grant number: 2017YFD0400300) to Tongcun
   Zhang.
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NR 127
TC 3
Z9 3
U1 2
U2 8
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2304-8158
J9 FOODS
JI Foods
PD SEP
PY 2023
VL 12
IS 18
AR 3393
DI 10.3390/foods12183393
PG 19
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA T9DA1
UT WOS:001080904300001
PM 37761102
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Lee, TH
   Chen, JJ
   Wu, CY
   Yang, CW
   Yang, HY
AF Lee, Tao Han
   Chen, Jia-Jin
   Wu, Chao-Yi
   Yang, Chih-Wei
   Yang, Huang-Yu
TI Hyperuricemia and Progression of Chronic Kidney Disease: A Review from
   Physiology and Pathogenesis to the Role of Urate-Lowering Therapy
SO DIAGNOSTICS
LA English
DT Review
DE hyperuricemia; gout; chronic kidney disease; xanthine oxidase inhibitor;
   allopurinol; febuxostat
ID SERUM URIC-ACID; BLOOD-PRESSURE; CARDIOVASCULAR EVENTS; METABOLIC
   SYNDROME; ASYMPTOMATIC HYPERURICEMIA; MILD HYPERURICEMIA; NALP3
   INFLAMMASOME; GOUT; ALLOPURINOL; RISK
AB The relationship between hyperuricemia, gout, and renal disease has been investigated for several years. From the beginning, kidney disease has been considered a complication of gout; however, the viewpoints changed, claiming that hypertension and elevated uric acid (UA) levels are caused by decreased urate excretion in patients with renal impairment. To date, several examples of evidence support the role of hyperuricemia in cardiovascular or renal diseases. Several mechanisms have been identified that explain the relationship between hyperuricemia and chronic kidney disease, including the crystal effect, renin-angiotensin-aldosterone system activation, nitric oxide synthesis inhibition, and intracellular oxidative stress stimulation, and urate-lowering therapy (ULT) has been proven to reduce renal disease progression in the past few years. In this comprehensive review, the source and physiology of UA are introduced, and the mechanisms that explain the reciprocal relationship between hyperuricemia and kidney disease are reviewed. Lastly, current evidence supporting the use of ULT to postpone renal disease progression in patients with hyperuricemia and gout are summarized.
C1 [Lee, Tao Han; Chen, Jia-Jin; Yang, Chih-Wei; Yang, Huang-Yu] Chang Gung Univ, Chang Gung Mem Hosp, Coll Med, Dept Nephrol, Taoyuan 33305, Taiwan.
   [Wu, Chao-Yi] Chang Gung Univ, Chang Gung Mem Hosp, Coll Med, Dept Pediat,Div Allergy Asthma & Rheumatol, Taoyuan 33305, Taiwan.
   [Yang, Huang-Yu] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Hlth Policy & Management, Baltimore, MD 21205 USA.
C3 Chang Gung Memorial Hospital; Chang Gung University; Chang Gung Memorial
   Hospital; Chang Gung University; Johns Hopkins University; Johns Hopkins
   Bloomberg School of Public Health
RP Yang, HY (corresponding author), Chang Gung Univ, Chang Gung Mem Hosp, Coll Med, Dept Nephrol, Taoyuan 33305, Taiwan.; Yang, HY (corresponding author), Johns Hopkins Bloomberg Sch Publ Hlth, Dept Hlth Policy & Management, Baltimore, MD 21205 USA.
EM kate0327@hotmail.com; Raymond110234@hotmail.com; joywucgu@cgmh.org.tw;
   cwyang00@gmail.com; hyyang01@gmail.com
RI Chen, Jia-Jin/AAX-2147-2021; lee, tao/KWT-9328-2024
OI Chen, Jia-Jin/0000-0001-9508-5956; Lee, Tao Han/0000-0003-3650-7236;
   YANG, HUANG-YU/0000-0001-6826-9717
FU Chang Gung Memorial Hospital [CORPG5J0031]
FX This review article was supported by grants from the Chang Gung Memorial
   Hospital (CORPG5J0031).
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NR 114
TC 38
Z9 40
U1 5
U2 91
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2075-4418
J9 DIAGNOSTICS
JI Diagnostics
PD SEP
PY 2021
VL 11
IS 9
AR 1674
DI 10.3390/diagnostics11091674
PG 16
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA UV3VS
UT WOS:000699411100001
PM 34574015
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Senesi, P
   Luzi, L
   Terruzzi, I
AF Senesi, Pamela
   Luzi, Livio
   Terruzzi, Ileana
TI Adipokines, Myokines, and Cardiokines: The Role of Nutritional
   Interventions
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE cardiovascular diseases; metabolic syndrome; obesity; nutraceuticals;
   adipokines; myokines; cardiokines
ID ISCHEMIA-REPERFUSION INJURY; POLYUNSATURATED FATTY-ACIDS;
   VITAMIN-D-RECEPTOR; OXIDATIVE STRESS; CARDIAC-HYPERTROPHY; APELIN/APJ
   SYSTEM; CARDIOVASCULAR-DISEASE; NATRIURETIC PEPTIDES; CALORIE
   RESTRICTION; ADIPOSE-TISSUE
AB It is now established that adipose tissue, skeletal muscle, and heart are endocrine organs and secrete in normal and in pathological conditions several molecules, called, respectively, adipokines, myokines, and cardiokines. These secretory proteins constitute a closed network that plays a crucial role in obesity and above all in cardiac diseases associated with obesity. In particular, the interaction between adipokines, myokines, and cardiokines is mainly involved in inflammatory and oxidative damage characterized obesity condition. Identifying new therapeutic agents or treatment having a positive action on the expression of these molecules could have a key positive effect on the management of obesity and its cardiac complications. Results from recent studies indicate that several nutritional interventions, including nutraceutical supplements, could represent new therapeutic agents on the adipo-myo-cardiokines network. This review focuses the biological action on the main adipokines, myokines and cardiokines involved in obesity and cardiovascular diseases and describe the principal nutraceutical approaches able to regulate leptin, adiponectin, apelin, irisin, natriuretic peptides, and follistatin-like 1 expression.
C1 [Senesi, Pamela; Luzi, Livio; Terruzzi, Ileana] Univ Milan, Dept Biomed Sci Hlth, I-20131 Milan, Italy.
   [Senesi, Pamela; Luzi, Livio; Terruzzi, Ileana] IRCCS MultiMed, Dept Endocrinol Nutr & Metab Dis, I-20138 Milan, Italy.
C3 University of Milan; IRCCS Multimedica
RP Terruzzi, I (corresponding author), Univ Milan, Dept Biomed Sci Hlth, I-20131 Milan, Italy.; Terruzzi, I (corresponding author), IRCCS MultiMed, Dept Endocrinol Nutr & Metab Dis, I-20138 Milan, Italy.
EM pamela.senesi@unimi.it; livio.luzi@unimi.it; ileana.terruzzi@unimi.it
RI Senesi, Pamela/AAA-5678-2019; Terruzzi, Ileana/AAA-9737-2019
OI Senesi, Pamela/0000-0003-0304-1564; Terruzzi, Ileana/0000-0002-8663-4033
FU Italian Ministry of Health-Ricerca Corrente-IRCCS Multimedica
FX This work was supported by Italian Ministry of Health-Ricerca
   Corrente-IRCCS Multimedica.
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NR 206
TC 44
Z9 46
U1 0
U2 17
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD NOV
PY 2020
VL 21
IS 21
AR 8372
DI 10.3390/ijms21218372
PG 26
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA OR0LP
UT WOS:000589167000001
PM 33171610
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Drummond, GS
   Baum, J
   Greenberg, M
   Lewis, D
   Abraham, NG
AF Drummond, George S.
   Baum, Jeffrey
   Greenberg, Menachem
   Lewis, David
   Abraham, Nader G.
TI HO-1 overexpression and underexpression: Clinical implications
SO ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
LA English
DT Review
DE Obesity; Hyperbilirubinemia; Bilirubin; Adipocyte inflammation; Fatty
   liver; Hypertension
ID HEME OXYGENASE-1 GENE; HIGH-FAT DIET; IMPROVES INSULIN SENSITIVITY;
   PROMOTER MICROSATELLITE POLYMORPHISM; HEMOGLOBIN SCAVENGER RECEPTOR;
   INCREASES ADIPONECTIN LEVELS; CORONARY-ARTERY DISEASE; LOWERS
   BLOOD-PRESSURE; II-MEDIATED INCREASE; NF-KAPPA-B
AB In this review we examine the effects of both over- and under-production of heme oxygenase-1 (HO-1) and HO activity on a broad spectrum of biological systems and on vascular disease. In a few instances e.g., neonatal jaundice, overproduction of HO-1 and increased HO activity results in elevated levels of bilirubin requiring clinical intervention with inhibitors of HO activity. In contrast HO-1 levels and HO activity are low in obesity and the HO system responds to mitigate the deleterious effects of oxidative stress through increased levels of bilirubin (anti-inflammatory) and CO (anti-apoptotic) and decreased levels of heme (pro-oxidant). Site specific HO-1 overexpression diminishes adipocyte terminal differentiation and lipid accumulation of obesity mediated release of inflammatory molecules. A series of diverse strategies have been implemented that focus on increasing HO-1 and HO activity that are central to reversing the clinical complications associated with diseases including, obesity, metabolic syndrome and vascular disease.
C1 [Baum, Jeffrey; Greenberg, Menachem; Lewis, David; Abraham, Nader G.] New York Med Coll, Dept Med, Valhalla, NY 10595 USA.
   [Drummond, George S.; Baum, Jeffrey; Greenberg, Menachem; Lewis, David; Abraham, Nader G.] New York Med Coll, Dept Pharmacol, Valhalla, NY 10595 USA.
   [Abraham, Nader G.] Marshall Univ, Joan C Edwards Sch Med, Huntington, WV 25701 USA.
C3 New York Medical College; New York Medical College; Marshall University
RP Abraham, NG (corresponding author), New York Med Coll, Dept Med, Valhalla, NY 10595 USA.; Abraham, NG (corresponding author), New York Med Coll, Dept Pharmacol, Valhalla, NY 10595 USA.
EM nader_abraham@nymc.edu
FU National Institutes of Health [HL55601]
FX This work was supported by National Institutes of Health grants HL55601
   (NGA). We thank Mrs. Jennifer Brown for her outstanding assistance in
   preparing the manuscript.
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NR 259
TC 114
Z9 122
U1 1
U2 18
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0003-9861
EI 1096-0384
J9 ARCH BIOCHEM BIOPHYS
JI Arch. Biochem. Biophys.
PD SEP 30
PY 2019
VL 673
AR 108073
DI 10.1016/j.abb.2019.108073
PG 16
WC Biochemistry & Molecular Biology; Biophysics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics
GA LC6JK
UT WOS:000525439300001
PM 31425676
OA hybrid, Green Accepted
DA 2025-06-11
ER

PT J
AU Mousavizadeh, K
   Rajabi, P
   Alaee, M
   Dadgar, S
   Houshmand, M
AF Mousavizadeh, Kazem
   Rajabi, Peyman
   Alaee, Mahsa
   Dadgar, Sepideh
   Houshmand, Massoud
TI Usage of mitochondrial D-loop variation to predict risk for Huntington
   disease
SO MITOCHONDRIAL DNA
LA English
DT Article
DE Displacement loop; Huntington's disease; mitochondrial DNA;
   PCR-sequencing method; single nucleotide polymorphism
ID OXIDATIVE STRESS; DNA VARIANT; METABOLIC SYNDROME; IDENTIFICATION;
   DYSFUNCTION; MUTATIONS; REPEAT; SUSCEPTIBILITY; DELETIONS; DAMAGE
AB Huntington's disease (HD) is an inherited autosomal neurodegenerative disease caused by the abnormal expansion of the CAG repeats in the Huntingtin (Htt) gene. It has been proven that mitochondrial dysfunction is contributed to the pathogenesis of Huntington's disease. The mitochondrial displacement loop (D-loop) is proven to accumulate mutations at a higher rate than other regions of mtDNA. Thus, we hypothesized that specific SNPs in the D-loop may contribute to the pathogenesis of Huntington's disease. In the present study, 30 patients with Huntington's disease and 463 healthy controls were evaluated for mitochondrial mutation sites within the D-loop region using PCR-sequencing method. Sequence analysis revealed 35 variations in HD group from Cambridge Mitochondrial Sequences. A significant difference (p<0.05) was seen between patients and control group in eight SNPs. Polymorphisms at C16069T, T16126C, T16189C, T16519C and C16223T were correlated with an increased risk of HD while SNPs at C16150T, T16086C and T16195C were associated with a decreased risk of Huntington's disease.
C1 [Mousavizadeh, Kazem; Rajabi, Peyman; Alaee, Mahsa] Iran Univ Med Sci, Dept Mol Med, Tehran, Iran.
   [Rajabi, Peyman; Alaee, Mahsa] Univ Tehran Med Sci, Dept Med Biotechnol, Tehran, Iran.
   [Dadgar, Sepideh; Houshmand, Massoud] Special Med Ctr, Dept Genet, Tehran, Iran.
   [Houshmand, Massoud] Natl Inst Genet Engn & Biotechnol, Dept Med Genet, Tehran, Iran.
C3 Iran University of Medical Sciences; Tehran University of Medical
   Sciences
RP Houshmand, M (corresponding author), Natl Inst Genet Engn & Biotechnol, Dept Med Genet, Tehran, Iran.
EM massoudh@nigeb.ac.ir
RI Houshmand, Massoud/AEG-9909-2022
OI Mousavizadeh, Kazem/0000-0001-9695-2337; Houshmand,
   Massoud/0000-0002-2198-223X; mousavizadeh, kazem/0000-0002-4213-5523; ,
   Masoud/0000-0001-7687-7464
FU Iran University of Medical Sciences
FX The authors report no conflicts of interest. The authors alone are
   responsible for the content and writing of this article. This research
   was supported by a research grant from Iran University of Medical
   Sciences.
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NR 34
TC 16
Z9 17
U1 0
U2 18
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1940-1736
EI 1940-1744
J9 MITOCHONDR DNA
JI Mitochondrial DNA
PD AUG
PY 2015
VL 26
IS 4
BP 579
EP 582
DI 10.3109/19401736.2013.878902
PG 4
WC Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Genetics & Heredity
GA CP7VW
UT WOS:000360098200014
PM 24471944
DA 2025-06-11
ER

PT J
AU Turfan, M
   Tasal, A
   Erdogan, E
   Vatankulu, MA
   Jafarov, P
   Sonmez, O
   Ertas, G
   Bacaksiz, A
   Ergelen, M
   Goktekin, O
AF Turfan, Murat
   Tasal, Abdurrahman
   Erdogan, Ercan
   Vatankulu, Mehmet Akif
   Jafarov, Parviz
   Sonmez, Osman
   Ertas, Gokhan
   Bacaksiz, Ahmet
   Ergelen, Mehmet
   Goktekin, Omer
TI Serum gamma-glutamyl transferase levels and in-hospital mortality in
   patients with acute heart failure
SO KARDIOLOGIA POLSKA
LA English
DT Article
DE gamma-glutamyl transferase; in-hospital mortality; acute heart failure
ID CARDIOVASCULAR-DISEASE MORTALITY; METABOLIC SYNDROME; OXIDATIVE STRESS;
   KOREAN ADULTS; RISK; ASSOCIATION; PREDICTOR; HEALTH; LIVER
AB Background: Acute heart failure (AHF) is a major cause of hospitalisation, morbidity and mortality worldwide. Gamma-glutamyl transferase (GGT) is an enzyme responsible for the extracellular catabolism of antioxidant glutathione and a potential risk indicator of cardiac mortality. Limited data exists on the prognostic value of circulating levels of GGT in patients hospitalised due to AHF.
   Aim: To study the association between baseline GGT activity and in-hospital mortality in AHF patients.
   Methods: The study cohort consisted of 183 AHF patients with left ventricular ejection fraction (LVEF) < 50%. The primary endpoint was in-hospital mortality. Patients were divided into two groups according to in-hospital mortality. The relationship between GGT activity and in-hospital mortality was tested using logistic regression models, adjusting for clinical characteristics and echocardiographic findings.
   Results: After adjustment for possible confounders, GGT level was significantly related (OR 1.056, 95% CI 1.018-1.096, p = 0.04) to in-hospital mortality
   Conclusions: Elevated GGT activity is an independent predictor of short-term mortality in patients with AHF and reduced LVEF.
C1 [Turfan, Murat; Tasal, Abdurrahman; Erdogan, Ercan; Vatankulu, Mehmet Akif; Jafarov, Parviz; Sonmez, Osman; Ertas, Gokhan; Bacaksiz, Ahmet; Ergelen, Mehmet; Goktekin, Omer] Bezmialem Vakif Univ, Dept Cardiol, Istanbul, Turkey.
C3 Bezmialem Vakif University
RP Turfan, M (corresponding author), Bezmialem Vakif Univ, Dept Cardiol, Istanbul, Turkey.
EM turphan@gmail.com
RI Erdogan, Ercan/H-4114-2013; Ertas, G/AAG-8379-2019; Turfan,
   Murat/B-8972-2014
OI Tasal, Abdurrahman/0000-0003-4506-6348; Sonmez,
   Osman/0000-0002-9871-8146; Ergelen, Mehmet/0009-0007-1559-5480; Ertas,
   Gokhan/0000-0002-9077-8814; Erdogan, Ercan/0009-0003-8941-2342
CR Abdul-Rasheed Omar F, 2010, Oman Med J, V25, P286, DOI 10.5001/omj.2010.83
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NR 27
TC 6
Z9 6
U1 0
U2 3
PU VIA MEDICA
PI GDANSK
PA UL SWIETOKRZYSKA 73, 80-180 GDANSK, POLAND
SN 0022-9032
EI 1897-4279
J9 KARDIOL POL
JI Kardiol. Pol.
PY 2014
VL 72
IS 8
BP 735
EP 739
DI 10.5603/KP.a2014.0048
PG 5
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA AO3QB
UT WOS:000341247300008
PM 24526562
OA hybrid
DA 2025-06-11
ER

PT J
AU Pomponi, MFL
   Gambassi, G
   Pomponi, M
   Di Gioia, A
   Masullo, C
AF Pomponi, Massimo F. L.
   Gambassi, Giovanni
   Pomponi, Massimiliano
   Di Gioia, Annamaria
   Masullo, Carlo
TI Why docosahexaenoic acid and aspirin supplementation could be useful in
   women as a primary prevention therapy against Alzheimer's disease?
SO AGEING RESEARCH REVIEWS
LA English
DT Review
DE Alzheimer's disease prevention; Sex-specific risk factors;
   Docosahexaenoic acid; Aspirin
ID NONSTEROIDAL ANTIINFLAMMATORY DRUGS; BLOOD-BRAIN-BARRIER; AMYLOID
   BURDEN; LIPID-PEROXIDATION; GENDER-DIFFERENCES; METABOLIC SYNDROME;
   OXIDATIVE STRESS; FISH-OIL; DEMENTIA; RISK
AB The assumption that disease specific risk factors are similar or the same in men and women may lead to incorrect primary prevention strategies. This study focused on the evaluation of gender-specific Alzheimer's disease (AD) risk factors. In AD, female gender appears to be an important risk factor associated with the aberrant production of beta amyloid (beta A) peptides. Although decreased levels in plasma DHA concentration are associated with cognitive decline in healthy elderly and Alzheimer's patients, pretreatment with DHA significantly reduced the survival of cortical neurons incubated with beta amyloid (beta A). Hence, in the presence of an increasing amount of beta A, paradoxically women - who have higher plasma levels of DHA - are more likely to develop AD. Aspirin (ASA) converts cyclooxygenase (COX)-2 into a form that generates new neuroprotective docosanoids from DHA; therefore, ASA might positively resolve the paradoxical effect of the concomitant presence of DHA and beta A. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Pomponi, Massimo F. L.] UCSC, Ist Biochim & Biochim Clin, I-00168 Rome, Italy.
   [Gambassi, Giovanni] UCSC, Ctr Med Invecchiamento, I-00168 Rome, Italy.
   [Pomponi, Massimiliano; Di Gioia, Annamaria] UCSC, Ist Psichiatria, I-00168 Rome, Italy.
   [Masullo, Carlo] UCSC, Ist Neurol, I-00168 Rome, Italy.
C3 Catholic University of the Sacred Heart; Catholic University of the
   Sacred Heart; Catholic University of the Sacred Heart; Catholic
   University of the Sacred Heart
RP Pomponi, MFL (corresponding author), UCSC, Ist Biochim & Biochim Clin, Largo F Vito 1, I-00168 Rome, Italy.
EM m.pomponi@rm.unicatt.it; giovanni_gambassi@rm.unicatt.it;
   massimilianopomponi@alice.it; annamariadigioia@alice.it;
   cmasullo@rm.unicatt.it
RI Cammarota, Giovanni/AAD-1732-2022
OI Gambassi, Giovanni/0000-0002-7030-9359
FU National Ministero dell'Istruzione, dell'Universita e della Ricerca
   (MIUR)
FX This work was supported by the National Ministero dell'Istruzione,
   dell'UniversitA e della Ricerca (MIUR).
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NR 88
TC 14
Z9 15
U1 0
U2 14
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 1568-1637
EI 1872-9649
J9 AGEING RES REV
JI Ageing Res. Rev.
PD JAN
PY 2011
VL 10
IS 1
SI SI
BP 124
EP 131
DI 10.1016/j.arr.2010.09.003
PG 8
WC Cell Biology; Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Geriatrics & Gerontology
GA 717SY
UT WOS:000287068900013
PM 20920611
DA 2025-06-11
ER

PT J
AU Wang, K
   Xu, QP
   Xia, L
   Sun, JN
   Shen, KE
   Liu, HR
   Xu, LN
   Li, R
AF Wang, Kun
   Xu, Qingpeng
   Xia, Lu
   Sun, Jianing
   Shen, Kanger
   Liu, Haoran
   Xu, Linning
   Li, Rui
TI Gallbladder polypoid lesions: Current practices and future prospects
SO CHINESE MEDICAL JOURNAL
LA English
DT Review
DE Gallbladder neoplasms; Benign polyps; Malignant polyps; Risk factors;
   Biological mechanism; Diagnosis; Treatment
ID NOTES TRANSVAGINAL CHOLECYSTECTOMY; RISK-FACTORS;
   DIFFERENTIAL-DIAGNOSIS; ENDOSCOPIC ULTRASONOGRAPHY; METABOLIC SYNDROME;
   FOLLOW-UP; MOLECULAR-MECHANISMS; NATURAL-HISTORY; CANCER; ULTRASOUND
AB Gallbladder polypoid lesions (GPLs) refer to any elevated lesion of the mucosal surface of the gallbladder wall, and the prevalence is estimated to be between 0.9% and 12.1%. GPLs include benign polyps and malignant polyps. Benign polyps are further classified as non-neoplastic polyps and neoplastic polyps. Cholesterol polyps are the most common benign polyps and adenocarcinoma is the main type of malignant polyp. Hepatitis B virus infection, liver function abnormalities, dyslipidemia, and obesity are the main risk factors for GPLs. Studies of biological mechanisms have focused on malignant gallbladder polyps, the development of which is regulated by hormone levels in vivo, gut microbiota, inflammation, oxidative stress, Salmonella typhimurium, and related molecules. Diagnostic modalities include chemical examination and imaging examination, with imaging examination currently being the mainstay. Treatment of patients with GPLs is based on the presence or absence of symptoms, age, size of the polyps, tendency of the polyp to increase, and risk factors for symptomatic malignancy to determine whether surgery should be performed.
C1 [Wang, Kun; Xu, Qingpeng; Xia, Lu; Sun, Jianing; Shen, Kanger; Liu, Haoran; Xu, Linning; Li, Rui] Soochow Univ, Affiliated Hosp 1, Dept Gastroenterol, Suzhou 215026, Jiangsu, Peoples R China.
C3 Soochow University - China
RP Li, R (corresponding author), Soochow Univ, Affiliated Hosp 1, Dept Gastroenterol, Suzhou 215026, Jiangsu, Peoples R China.
EM lrhcsz@163.com
RI liu, haoran/JMP-8256-2023
FU Jiangsu Province-Establishment of an endoscopic diagnosis and treatment
   system for submucosal tumors of the digestive tract and optimization of
   key technologies [BE2019667]
FX This review was funded by Jiangsu Province-Establishment of an
   endoscopic diagnosis and treatment system for submucosal tumors of the
   digestive tract and optimization of key technologies (No. BE2019667).
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NR 98
TC 3
Z9 3
U1 1
U2 7
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0366-6999
EI 2542-5641
J9 CHINESE MED J-PEKING
JI Chin. Med. J.
PD JUL 20
PY 2024
VL 137
IS 14
BP 1674
EP 1683
DI 10.1097/CM9.0000000000003019
PG 10
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA ZG5O3
UT WOS:001274157700008
PM 38420780
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Raman, P
   Khanal, S
AF Raman, Priya
   Khanal, Saugat
TI Leptin in Atherosclerosis: Focus on Macrophages, Endothelial and Smooth
   Muscle Cells
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE hyperleptinemia; endothelial cells; vascular smooth muscle cells;
   macrophages; atherosclerosis
ID ADIPOSE-TISSUE; CARDIOVASCULAR-DISEASE; NEOINTIMA FORMATION; SIGNALING
   PATHWAYS; METABOLIC SYNDROME; POTENTIAL ROLE; SERUM LEPTIN;
   MYOCARDIAL-INFARCTION; OXIDATIVE STRESS; ARTERIAL INJURY
AB Increasing adipose tissue mass in obesity directly correlates with elevated circulating leptin levels. Leptin is an adipokine known to play a role in numerous biological processes including regulation of energy homeostasis, inflammation, vascular function and angiogenesis. While physiological concentrations of leptin may exhibit multiple beneficial effects, chronically elevated pathophysiological levels or hyperleptinemia, characteristic of obesity and diabetes, is a major risk factor for development of atherosclerosis. Hyperleptinemia results in a state of selective leptin resistance such that while beneficial metabolic effects of leptin are dampened, deleterious vascular effects of leptin are conserved attributing to vascular dysfunction. Leptin exerts potent proatherogenic effects on multiple vascular cell types including macrophages, endothelial cells and smooth muscle cells; these effects are mediated via an interaction of leptin with the long form of leptin receptor, abundantly expressed in atherosclerotic plaques. This review provides a summary of recent in vivo and in vitro studies that highlight a role of leptin in the pathogenesis of atherosclerotic complications associated with obesity and diabetes.
C1 [Raman, Priya; Khanal, Saugat] Northeast Ohio Med Univ, Integrat Med Sci, Rootstown, OH 44272 USA.
   [Raman, Priya; Khanal, Saugat] Kent State Univ, Sch Biomed Sci, Kent, OH 44240 USA.
C3 University System of Ohio; Northeast Ohio Medical University (NEOMED);
   University System of Ohio; Kent State University; Kent State University
   Kent; Kent State University Salem
RP Raman, P (corresponding author), Northeast Ohio Med Univ, Integrat Med Sci, Rootstown, OH 44272 USA.; Raman, P (corresponding author), Kent State Univ, Sch Biomed Sci, Kent, OH 44240 USA.
EM praman@neomed.edu; skhanal@neomed.edu
FU Ameriacn Heart Association Scientist Development [0835190N,
   1R15HL147245-01]; Northeast Ohio Medical University (NEOMED) start-up
   funds; American Heart Association (AHA) [0835190N] Funding Source:
   American Heart Association (AHA)
FX This work was supported in part by Ameriacn Heart Association Scientist
   Development Grant 0835190N, 1R15HL147245-01 and Northeast Ohio Medical
   University (NEOMED) start-up funds to P.R.
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NR 123
TC 51
Z9 54
U1 1
U2 13
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD JUN
PY 2021
VL 22
IS 11
AR 5446
DI 10.3390/ijms22115446
PG 19
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA SQ2JW
UT WOS:000660185000001
PM 34064112
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Guo, H
   Zhang, QL
   Yuan, HP
   Zhou, L
   Li, FF
   Wang, SM
   Shi, G
   Wang, MJ
AF Guo, Hua
   Zhang, Qinglan
   Yuan, Haipo
   Zhou, Lin
   Li, Fang-fang
   Wang, Sheng-Ming
   Shi, Gang
   Wang, Maojuan
TI Nitric Oxide Mediates Inflammation in Type II Diabetes Mellitus through
   the PPARγ/eNOS Signaling Pathway
SO PPAR RESEARCH
LA English
DT Article
ID METABOLIC SYNDROME; INDUCTION; PROMISE; MARKERS; STRESS; CELLS
AB Inflammation accounts for the process of type II diabetes mellitus (T2DM), the specific mechanism of which is still to be elucidated yet. Nitric oxide (NO), a critical inflammation regulator, the role of which is the inflammation of T2DM, is rarely reported. Therefore, our study is aimed at exploring the effect of NO on the inflammation in T2DM and the corresponding mechanism. We analyzed the NO levels in plasma samples from T2DM patients and paired healthy adults by Nitric Oxide Analyzer then measured the expression of inflammatory cytokines (C-reactive protein, heptoglobin, IL-1 beta, TNF-alpha, IL-6) in insulin-induced HepG2 cells treated with NO donor or NO scavenger, and the PPAR gamma, eNOS, C-reactive protein, heptoglobin, IL-1 beta, TNF-alpha, and IL-6 levels were detected by RT-PCR and western blot in insulin-induced HepG2 cells transfected with si-PPAR gamma. The results showed that excess NO increased the inflammation marker levels in T2DM, which is activated by the PPAR gamma/eNOS pathway. These findings will strengthen the understanding of NO in T2DM and provide a new target for the treatment of T2DM.
C1 [Guo, Hua] Hosp Chengdu Univ Tradit Chinese Med, Dept Clin Lab, Chengdu, Peoples R China.
   [Zhang, Qinglan] Chongqing Hosp Tradit Chinese Med, Dept Endocrinol, Chongqing, Peoples R China.
   [Yuan, Haipo] Hosp Chengdu Univ Tradit Chinese Med, Dept Endocrinol, Chengdu, Peoples R China.
   [Zhou, Lin; Li, Fang-fang] Xuzhou Med Univ, Affiliated Huaian Hosp, Huaian Peoples Hosp 2, Dept Ophthalmol, Huaian, Jiangsu, Peoples R China.
   [Wang, Sheng-Ming] Xuzhou Med Univ, Affiliated Huaian Hosp, Huaian Peoples Hosp 2, Dept Stomatol, Huaian, Jiangsu, Peoples R China.
   [Shi, Gang] Hosp Chengdu Univ Tradit Chinese Med, Dept Pharm Serv, Chengdu, Peoples R China.
   [Wang, Maojuan] Hosp Chengdu Univ Tradit Chinese Med, Dept Outpatient, Chengdu, Peoples R China.
C3 Chengdu University of Traditional Chinese Medicine; Chengdu University
   of Traditional Chinese Medicine; Xuzhou Medical University; Xuzhou
   Medical University; Chengdu University of Traditional Chinese Medicine;
   Chengdu University of Traditional Chinese Medicine
RP Shi, G (corresponding author), Hosp Chengdu Univ Tradit Chinese Med, Dept Pharm Serv, Chengdu, Peoples R China.; Wang, MJ (corresponding author), Hosp Chengdu Univ Tradit Chinese Med, Dept Outpatient, Chengdu, Peoples R China.
EM madpanda1978@163.com; zql2002702@163.com; yuanhaipo3075@163.com;
   20194133137@stu.suda.edu.cn; m13382339055@163.com; m15061225191@163.com;
   shigangctu@163.com; wmjlxc1029@163.com
RI Li, Fangfang/D-9908-2013; guo, hua/JJE-7793-2023
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NR 33
TC 12
Z9 14
U1 0
U2 18
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1687-4757
EI 1687-4765
J9 PPAR RES
JI PPAR Res.
PD NOV 27
PY 2020
VL 2020
AR 8889612
DI 10.1155/2020/8889612
PG 7
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA PE5FM
UT WOS:000598391500001
PM 33293942
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Gong, G
   Hargrave, KA
   Hobson, V
   Spallholz, J
   Boylan, M
   Lefforge, D
   O'Bryant, SE
AF Gong, Gordon
   Hargrave, Kristopher A.
   Hobson, Valerie
   Spallholz, Julian
   Boylan, Mallory
   Lefforge, David
   O'Bryant, Sid E.
TI Low-Level Groundwater Arsenic Exposure Impacts Cognition: A Project
   FRONTIER Study
SO JOURNAL OF ENVIRONMENTAL HEALTH
LA English
DT Article
ID CHILDRENS INTELLECTUAL FUNCTION; S-TRANSFERASE OMEGA-1;
   MINI-MENTAL-STATE; DRINKING-WATER; ALZHEIMER-DISEASE; SODIUM ARSENITE;
   METABOLIC SYNDROME; OXIDATIVE STRESS; FOLLOW-UP; BANGLADESH
AB Arsenic is a ubiquitous environmental toxin with known neurological consequences. Few studies, however, have investigated groundwater arsenic concentrations and cognition among adults and elders. In the study described in this article, the authors examined the potential link between cognitive functioning and low concentrations of arsenic in drinking water. Arsenic concentrations were estimated by the Geographic Information System approach (GIS-arsenic) for 299 rural-dwelling adults and elders. Cognition was assessed with Folstein Mini-Mental State Examination (MMSE). Those in the relatively high GIS-arsenic exposure (>10.0 mu g/L) group had significantly lower MMSE scores than those in the low GIS-arsenic exposure (<= 10.0 mu g/L) group (p < .03). The number of years of education was significantly lower in those in the high GIS-arsenic group(s) than in those in the low GIS-arsenic group (p < .05). These results suggest that poorer cognitive functioning and lower education levels were associated with higher (though still low-level) GIS-arsenic levels in this rural adult cohort.
EM sid.obryant@ttuhsc.edu
OI O'Bryant, Sid/0000-0003-0582-5266
FU Carl B. & Florence E. King Foundation of Dallas, Texas; South Plains
   Foundation
FX This study was funded in part by the Carl B. & Florence E. King
   Foundation of Dallas, Texas. The funding source had no input into data
   collection, study design, analysis, interpretation of the data, or
   writing of the manuscript. The authors would like to thank the entire
   research team with special thanks to the people of Cochran County as
   well as our advisory board, particularly Nancy Luper; without their help
   this project would not be possible. We thank Cochran County Memorial
   Hospital and its staff for all of their assistance and provision of
   office space. This work would not have been possible without the
   assistance of our community recruiters Joel Torango and Cynthia Ramirez.
   We thank Dr. Mohammad Alauddin, Wagner College, New York, for his
   assistance in measuring water arsenic concentration from sample wells.
   The measurement of arsenic concentrations in seven wells in Texas was
   funded by South Plains Foundation.
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TC 24
Z9 29
U1 1
U2 18
PU NATL ENVIRON HEALTH ASSOC
PI DENVER
PA 720 S COLORADO BLVD SUITE 970, SOUTH TOWER, DENVER, CO 80246 USA
SN 0022-0892
J9 J ENVIRON HEALTH
JI J. Environ. Health
PD SEP
PY 2011
VL 74
IS 2
BP 16
EP 22
PG 7
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA 816IR
UT WOS:000294592400003
PM 21949980
DA 2025-06-11
ER

PT J
AU Cowan, S
   Lim, S
   Alycia, C
   Pirotta, S
   Thomson, R
   Gibson-Helm, M
   Blackmore, R
   Naderpoor, N
   Bennett, C
   Ee, C
   Rao, VBT
   Mousa, A
   Alesi, S
   Moran, L
AF Cowan, Stephanie
   Lim, Siew
   Alycia, Chelsea
   Pirotta, Stephanie
   Thomson, Rebecca
   Gibson-Helm, Melanie
   Blackmore, Rebecca
   Naderpoor, Negar
   Bennett, Christie
   Ee, Carolyn
   Rao, Vibhuti
   Mousa, Aya
   Alesi, Simon
   Moran, Lisa
TI Lifestyle management in polycystic ovary syndrome - beyond diet and
   physical activity
SO BMC ENDOCRINE DISORDERS
LA English
DT Review
DE Polycystic ovary syndrome; diet; guideline; physical activity; sleep;
   cognitive behavioural therapy; quality of life; complementary medicine
ID OBSTRUCTIVE SLEEP-APNEA; BODY-MASS INDEX; CARDIOMETABOLIC RISK-FACTORS;
   VITAMIN-D SUPPLEMENTATION; MENTAL-HEALTH PARAMETERS; ALTERNATIVE
   MEDICINE CAM; STOP HYPERTENSION DIET; QUALITY-OF-LIFE; WEIGHT-LOSS;
   OBESE WOMEN
AB Polycystic ovary syndrome (PCOS) is a common condition affecting reproductive-aged women with reproductive, metabolic and psychological consequences. Weight and lifestyle (diet, physical activity and behavioural) management are first-line therapy in international evidence-based guidelines for PCOS. While these recommend following population-level diet and physical activity guidelines, there is ongoing interest and research in the potential benefit of including psychological and sleep interventions, as well as a range of traditional, complimentary and integrative medicine (TCIM) approaches, for optimal management of PCOS. There is limited evidence to recommend a specific diet composition for PCOS with approaches including modifying protein, carbohydrate or fat quality or quantity generally having similar effects on the presentations of PCOS. With regards to physical activity, promising evidence supports the provision of vigorous aerobic exercise, which has been shown to improve body composition, cardiorespiratory fitness and insulin resistance. Psychological and sleep interventions are also important considerations, with women displaying poor emotional wellbeing and higher rates of clinical and subclinical sleep disturbance, potentially limiting their ability to make positive lifestyle change. While optimising sleep and emotional wellbeing may aid symptom management in PCOS, research exploring the efficacy of clinical interventions is lacking. Uptake of TCIM approaches, in particular supplement and herbal medicine use, by women with PCOS is growing. However, there is currently insufficient evidence to support integration into routine clinical practice. Research investigating inositol supplementation have produced the most promising findings, showing improved metabolic profiles and reduced hyperandrogenism. Findings for other supplements, herbal medicines, acupuncture and yoga is so far inconsistent, and to reduce heterogeneity more research in specific PCOS populations, (e.g. defined age and BMI ranges) and consistent approaches to intervention delivery, duration and comparators are needed. While there are a range of lifestyle components in addition to population-recommendations for diet and physical activity of potential benefit in PCOS, robust clinical trials are warranted to expand the relatively limited evidence-base regarding holistic lifestyle management. With consumer interest in holistic healthcare rising, healthcare providers will be required to broaden their knowledge pertaining to how these therapies can be safely and appropriately utilised as adjuncts to conventional medical management.
C1 [Cowan, Stephanie; Alycia, Chelsea; Gibson-Helm, Melanie; Naderpoor, Negar; Mousa, Aya; Alesi, Simon; Moran, Lisa] Monash Univ, Monash Ctr Hlth Res & Implementat, Clayton, Vic, Australia.
   [Lim, Siew] Monash Univ, Eastern Hlth Clin Sch, Box Hill, Vic, Australia.
   [Pirotta, Stephanie] Monash Univ, Hlth & Social Care Unit, Clayton, Vic, Australia.
   [Thomson, Rebecca] Univ Adelaide, Robinson Res Inst, North Adelaide, SA, Australia.
   [Gibson-Helm, Melanie] Te Herenga Waka Victoria Univ Wellington, Te Tatai Hauora Hine Natl Ctr Womens Hlth Res Aote, Wellington, New Zealand.
   [Blackmore, Rebecca] Swinburne Univ Technol, Ctr Mental Hlth, Hawthorn, Vic, Australia.
   [Bennett, Christie] Monash Univ, Dept Nutr Dietet & Food, Notting Hill, Vic, Australia.
   [Ee, Carolyn; Rao, Vibhuti] Western Sydney Univ, NICM Hlth Res Inst, Westmead, NSW, Australia.
C3 Monash University; Monash University; Monash University; Robinson
   Research Institute; University of Adelaide; Swinburne University of
   Technology; Monash University; Western Sydney University
RP Cowan, S (corresponding author), Monash Univ, Monash Ctr Hlth Res & Implementat, Clayton, Vic, Australia.
EM stephanie.cowan@monash.edu
RI Rao, Vibhuti/LDG-5410-2024; Mousa, Aya/AFU-5166-2022; Naderpoor,
   Negar/IUM-7706-2023; Blackmore, Rebecca/ABG-4566-2021; Bennett,
   Christie/AAH-5042-2019; Moran, Lisa/E-9850-2015; Thomson,
   Rebecca/AAL-8597-2021; Ee, Carolyn/V-5070-2019; K, Ajith/JZJ-6503-2024
OI Moran, Lisa/0000-0001-5772-6484; Rao, Vibhuti/0000-0003-2614-6457;
   Mousa, Aya/0000-0002-7356-4523; Cowan, Stephanie/0000-0001-6731-4221;
   Blackmore, Rebecca/0000-0002-4617-0609; Ee, Carolyn/0000-0002-3363-9199;
   K, Ajith/0000-0001-7080-3229; Naderpoor, Negar/0000-0002-1738-3189; Lim,
   Siew/0000-0002-5333-6451
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NR 296
TC 72
Z9 76
U1 12
U2 75
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1472-6823
J9 BMC ENDOCR DISORD
JI BMC Endocr. Disord.
PD JAN 16
PY 2023
VL 23
IS 1
AR 14
DI 10.1186/s12902-022-01208-y
PG 33
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 7Z3YS
UT WOS:000915499100002
PM 36647089
OA gold, Green Published
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Dayal, U
   Soni, U
   Bansal, S
   Aggarwal, K
   Chennupati, C
   Kanagala, SG
   Gupta, V
   Munjal, RS
   Jain, R
AF Dayal, Utkarsh
   Soni, Ujjwal
   Bansal, Sourav
   Aggarwal, Kanishk
   Chennupati, Chaitanya
   Kanagala, Sai G.
   Gupta, Vasu
   Munjal, Ripudaman S.
   Jain, Rohit
TI MAFLD: Exploring the Systemic Effects Beyond Liver
SO JOURNAL OF COMMUNITY HOSPITAL INTERNAL MEDICINE PERSPECTIVES
LA English
DT Review
DE MAFLD; NAFLD; NASH; Metabolic syndrome; CVD; CKD
ID NONALCOHOLIC FATTY LIVER; DISEASE; PATHOGENESIS; NAFLD
AB Metabolic dysfunction-associated fatty liver disease (MAFLD) is a growing global health concern which is driven by the increasing prevalence of diabetes and obesity. MAFLD is characterized by excessive fat accumulation in the liver, which encompasses a range of conditions, from simple hepatic steatosis to more severe forms. This condition is associated with various complications, including chronic kidney disease (CKD), Cardiovascular Disease (CVD), liver cirrhosis, and even malignancy. Recent research has highlighted a potential connection between gut dysbiosis and MAFLD, particularly in relation to CKD. This has underscored the significance of the gut-liver-kidney axis in understanding MAFLD's pathogenesis. Inflammation triggered by MAFLD increases the risk of CVD through multiple mechanisms linked to metabolic dysfunction. These mechanisms include heightened oxidative stress, systemic and hepatic insulin resistance, low-grade inflammation, and endothelial dysfunction. Hepatic steatosis and metabolic dysfunction are major diagnostic criteria for MAFLD, often coexisting with other liver ailments. This prospective review emphasizes the intricate associations between MAFLD, cardiovascular complications, renal issues, and hepatic diseases. Understanding the underlying pathophysiological pathways is crucial in comprehending the increased risk of CKD, CVD, and other hepatic complications in individuals with MAFLD.
C1 [Dayal, Utkarsh] St Vincent Hosp, Dept Internal Med, Worcester, MA USA.
   [Bansal, Sourav] Govt Med Coll, Dept Internal Med, Amritsar, Punjab, India.
   [Aggarwal, Kanishk] Dayanand Med Coll & Hosp, Dept Internal Med, Ludhiana, India.
   [Chennupati, Chaitanya] Mt House High Sch, Hillsdale, MI 49242 USA.
   [Kanagala, Sai G.] Metropolitan Hosp Ctr, Dept Internal Med, New York, NY USA.
   [Gupta, Vasu] Cleveland Clin Akron Gen, Dept Internal Med, Akron, OH USA.
   [Munjal, Ripudaman S.] Touro Univ, Coll Osteopath Med, Pomona, CA USA.
   [Jain, Rohit] Penn State Hlth Milton S Hershey Med Ctr, Div Hosp Med, Hershey, PA USA.
   [Soni, Ujjwal] Univ Oklahoma Hlth Sci, Dept Internal Med, Oklahoma City, OK 73019 USA.
C3 Dayanand Medical College & Hospital; Metropolitan Hospital Center;
   Cleveland Clinic Foundation; Touro University California; Pennsylvania
   Commonwealth System of Higher Education (PCSHE); Pennsylvania State
   University; Penn State Health; University of Oklahoma System; University
   of Oklahoma Health Sciences Center
RP Soni, U (corresponding author), Univ Oklahoma Hlth Sci, Dept Internal Med, Oklahoma City, OK 73019 USA.
EM udayal1103@gmail.com; ujjwalsoni01@gmail.com; souravbansal30@gmail.com;
   aggarwals216@gmail.com; ck612008@gmail.com; gauthamkanagala@gmail.com;
   drgupta.vasu@gmail.com; munjal@hotmail.com; drrohitjain2010@gmail.com
RI Aggarwal, Kanishk/MBV-6086-2025; Munjal, Ripudaman/IZQ-2981-2023
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NR 41
TC 4
Z9 4
U1 5
U2 5
PU DIGITAL COMMONS BEPRESS
PI BERKELEY
PA 2100 MILVIA ST, STE 300, BERKELEY, CA 94704 USA
SN 2000-9666
J9 J COMM HOSP INT MED
JI J. Community Hosp. Intern. Med. Perspect.
PD JAN 6
PY 2025
VL 15
IS 1
DI 10.55729/2000-9666.1426
PG 9
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA R4R9X
UT WOS:001391353000018
PM 39867144
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Neto, CJCL
   de Melo, IMF
   Alpiovezza, PKBM
   de Albuquerque, YML
   Soares, AF
   Teixeira, AAC
   Wanderley-Teixeira, V
AF Neto, Clovis J. C. Lapa
   de Melo, Ismaela M. F.
   Alpiovezza, Paloma K. B. M.
   de Albuquerque, Yuri M. L.
   Soares, Anisio Francisco
   Teixeira, Alvaro A. C.
   Wanderley-Teixeira, Valeria
TI Melatonin associated with a high-fat diet during pregnancy and lactation
   prevents liver changes in the offspring
SO GENERAL AND COMPARATIVE ENDOCRINOLOGY
LA English
DT Article
DE High-fat diet; Rats; Histophysiology; Morphometry; Liver; Melatonin
ID OXIDATIVE STRESS; METABOLIC SYNDROME; INSULIN-RESISTANCE; HEPATIC
   GLUCONEOGENESIS; MATERNAL OBESITY; LIPID-METABOLISM; GRAPE SEED;
   CONSUMPTION; HOMEOSTASIS; PARAMETERS
AB In the present study, we set out to determine whether melatonin combined with a high-fat diet during pregnancy and lactation can prevent liver disorders in offspring. Forty rats were divided into four groups: DC - pregnant rats submitted to the standard diet; DC + Mel - pregnant rats submitted to the standard diet combined with melatonin; HFD - pregnant rats submitted to a high-fat diet; HFD + Mel - pregnant rats submitted to a high-fat diet combined with melatonin. Morphophysiological and biochemical parameters were analyzed. Melatonin (5 mg/ kg) was administered intraperitoneally. The HFD group offspring showed an increase in AST, ALT, alkaline phosphatase, cholesterol, triglycerides, LDL and glucose levels, and a reduction in HDL and lipase levels. In the liver obseved steatosis, hepatocellular ballooning, increased lobular parenchyma and reduced non-lobular parenchyma, beside reduced liver glycogen and fibrosis. These changes were not observed in the HFD + Mel group. In conclusion, melatonin combined with a high-fat diet preserves the liver architecture and function in the offspring.
C1 [Neto, Clovis J. C. Lapa; de Melo, Ismaela M. F.; Alpiovezza, Paloma K. B. M.; de Albuquerque, Yuri M. L.; Soares, Anisio Francisco; Teixeira, Alvaro A. C.; Wanderley-Teixeira, Valeria] Univ Fed Rural Pernambuco, Dept Morphol & Anim Physiol, Ave Dom Manoel de Medeiros S-N, BR-52171900 Recife, PE, Brazil.
C3 Universidade Federal Rural de Pernambuco (UFRPE)
RP Wanderley-Teixeira, V (corresponding author), Univ Fed Rural Pernambuco, Dept Morphol & Anim Physiol, Ave Dom Manoel de Medeiros S-N, BR-52171900 Recife, PE, Brazil.
EM valeria.wanderley@ufrpe.br
RI Lima de Albuquerque, Yuri/AEU-3457-2022; SOARES, ANÍSIO/AAS-6950-2021;
   Teixeira, Álvaro/I-2616-2017; Wanderley-Teixeira, Valeria/AAS-6380-2021
OI Wanderley Teixeira, Valeria/0000-0001-9533-5476; Lima de Albuquerque,
   Yuri/0000-0002-0580-9920
FU Pernambuco State Science and Technology Foundation (FACEPE)
   [IBPG-1244-5.05/15]
FX We would like to thank the Pernambuco State Science and Technology
   Foundation (FACEPE) for granting a scholarship to the first author
   (IBPG-1244-5.05/15).
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NR 84
TC 2
Z9 2
U1 0
U2 2
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0016-6480
EI 1095-6840
J9 GEN COMP ENDOCR
JI Gen. Comp. Endocrinol.
PD NOV 1
PY 2023
VL 343
AR 114357
DI 10.1016/j.ygcen.2023.114357
EA AUG 2023
PG 9
WC Endocrinology & Metabolism; Zoology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Zoology
GA R0KB1
UT WOS:001061304100001
PM 37586542
DA 2025-06-11
ER

PT J
AU Haghbin, H
   Gangwani, MK
   Ravi, JK
   Perisetti, A
   Aziz, M
   Goyal, H
   Nawras, A
   Sodeman, T
AF Haghbin, Hossein
   Gangwani, Manesh Kumar
   Ravi, Jai Kirshan
   Perisetti, Abhilash
   Aziz, Muhammad
   Goyal, Hemant
   Nawras, Ali
   Sodeman, Thomas
TI Nonalcoholic fatty liver disease and atrial fibrillation: possible
   pathophysiological links and therapeutic interventions
SO ANNALS OF GASTROENTEROLOGY
LA English
DT Review
DE Non-alcoholic fatty liver disease; atrial fibrillation; treatment;
   intervention; pathophysiology
ID C-REACTIVE PROTEIN; URSODEOXYCHOLIC ACID; UNITED-STATES;
   CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; OXIDATIVE STRESS;
   ANGIOTENSIN-II; OBESE-PATIENTS; HEART-FAILURE; WEIGHT-LOSS
AB Atrial fibrillation (AF) and nonalcoholic fatty liver disease (NAFLD) share common risk factors and appear to have an association. Independently, the incidence and prevalence of both diseases are on the rise. Epidemiological evidence, experimental studies and various randomized clinical trials suggest a link between the 2 entities, delineating cumulative risks and clinical strategies to improve outcomes. Dyslipidemia, insulin resistance, inflammatory milieu, and activation of the renin-angiotensin system are likely common pathophysiological mechanisms linking AF and NAFLD. In this article we review the known pathways and pathophysiology that link the 2 conditions. This review also discusses therapies that target both NAFLD and AF, such as angiotensin-converting enzyme inhibitors/angiotensin receptor blockers, statins, metformin, and vitamin E. We further discuss other potential medications that have shown effects in NAFLD or AF through anti-inflammatory, antidiabetic, lipid-lowering, or renin-angiotensin system inhibiting effects. Future epidemiological studies are needed to establish a direct causal relationship between NAFLD and AF.
C1 [Haghbin, Hossein; Aziz, Muhammad] Univ Toledo, Dept Internal Med, Med Ctr, 2801 W Bancroft St, Toledo, OH 43606 USA.
   [Gangwani, Manesh Kumar] Mercy Hosp St Louis, Dept Internal Med, St Louis, MO USA.
   [Ravi, Jai Kirshan] Guthrie Robert Packer Hosp, Dept Internal Med, Sayre, PA USA.
   [Perisetti, Abhilash] Univ Arkansas Med Sci, Dept Gastroenterol & Hepatol, Little Rock, AR 72205 USA.
   [Goyal, Hemant] Wright Ctr Grad Med Educ, Div Gastroenterol, Scranton, PA USA.
   [Nawras, Ali; Sodeman, Thomas] Univ Toledo, Div Gastroenterol & Hepatol, Med Ctr, 2801 W Bancroft St, Toledo, OH 43606 USA.
C3 University System of Ohio; University of Toledo; Saint Johns Mercy
   Medical Center; University of Arkansas System; University of Arkansas
   Medical Sciences; University System of Ohio; University of Toledo
RP Aziz, M (corresponding author), Univ Toledo, Med Ctr, 2801 W Bancroft St, Toledo, OH 43606 USA.
EM marajani@hotmail.com
RI Goyal, Hemant/E-3153-2012; Perisetti, Abhilash/L-2619-2019
OI GOYAL, HEMANT/0000-0002-9433-9042; Perisetti,
   Abhilash/0000-0003-4074-6395
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NR 118
TC 21
Z9 21
U1 3
U2 8
PU HELLENIC SOC GASTROENTEROLOGY
PI ATHENS
PA DEMOKRATIAS AVE 67, ATHENS, 15451, GREECE
SN 1108-7471
EI 1792-7463
J9 ANN GASTROENTEROL
JI Ann. Gastroenterol.
PY 2020
VL 33
IS 6
BP 603
EP 614
DI 10.20524/aog.2020.0550
PG 12
WC Gastroenterology & Hepatology
WE Emerging Sources Citation Index (ESCI)
SC Gastroenterology & Hepatology
GA PA2YE
UT WOS:000595498400006
PM 33162737
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Parveen, F
   Bender, D
   Law, SH
   Mishra, VK
   Chen, CC
   Ke, LY
AF Parveen, Farzana
   Bender, Daniel
   Law, Shi-Hui
   Mishra, Vineet Kumar
   Chen, Chih-Chieh
   Ke, Liang-Yin
TI Role of Ceramidases in Sphingolipid Metabolism and Human Diseases
SO CELLS
LA English
DT Review
DE neutral ceramidase; ceramide accumulation; metabolic syndrome; insulin
   resistance; type 2 diabetes; Alzheimer's disease; inflammatory bowel
   disease
ID HUMAN ACID CERAMIDASE; HUMAN ALKALINE CERAMIDASE; SPINAL
   MUSCULAR-ATROPHY; SATURATED FATTY-ACIDS; NEUTRAL CERAMIDASE;
   INSULIN-RESISTANCE; MOLECULAR-CLONING; OXIDATIVE STRESS;
   CELL-PROLIFERATION; FARBERS DISEASE
AB Human pathologies such as Alzheimer's disease, type 2 diabetes-induced insulin resistance, cancer, and cardiovascular diseases have altered lipid homeostasis. Among these imbalanced lipids, the bioactive sphingolipids ceramide and sphingosine-1 phosphate (S1P) are pivotal in the pathophysiology of these diseases. Several enzymes within the sphingolipid pathway contribute to the homeostasis of ceramide and S1P. Ceramidase is key in the degradation of ceramide into sphingosine and free fatty acids. In humans, five different ceramidases are known-acid ceramidase, neutral ceramidase, and alkaline ceramidase 1, 2, and 3-which are encoded by five different genes (ASAH1, ASAH2, ACER1, ACER2, and ACER3, respectively). Notably, the neutral ceramidase N-acylsphingosine amidohydrolase 2 (ASAH2) shows considerable differences between humans and animals in terms of tissue expression levels. Besides, the subcellular localization of ASAH2 remains controversial. In this review, we sum up the results obtained for identifying gene divergence, structure, subcellular localization, and manipulating factors and address the role of ASAH2 along with other ceramidases in human diseases.
C1 [Parveen, Farzana; Law, Shi-Hui; Mishra, Vineet Kumar; Ke, Liang-Yin] Kaohsiung Med Univ, Coll Hlth Sci, Dept Med Lab Sci & Biotechnol, Kaohsiung 80708, Taiwan.
   [Bender, Daniel] Univ Cologne, Inst Biochem, Dept Chem, D-50674 Cologne, Germany.
   [Chen, Chih-Chieh] Natl Sun Yat Sen Univ, Inst Med Sci & Technol, Kaohsiung 80424, Taiwan.
   [Ke, Liang-Yin] Kaohsiung Med Univ Hosp, Ctr Lipid Biosci, Kaohsiung 80708, Taiwan.
   [Ke, Liang-Yin] Kaohsiung Med Univ, Coll Med, Grad Inst Med, Kaohsiung 80708, Taiwan.
   [Ke, Liang-Yin] Kaohsiung Med Univ, Drug Dev & Value Creat Res Ctr, Kaohsiung 80708, Taiwan.
C3 Kaohsiung Medical University; University of Cologne; National Sun Yat
   Sen University; Kaohsiung Medical University; Kaohsiung Medical
   University Hospital; Kaohsiung Medical University; Kaohsiung Medical
   University
RP Ke, LY (corresponding author), Kaohsiung Med Univ, Coll Hlth Sci, Dept Med Lab Sci & Biotechnol, Kaohsiung 80708, Taiwan.; Ke, LY (corresponding author), Kaohsiung Med Univ Hosp, Ctr Lipid Biosci, Kaohsiung 80708, Taiwan.; Ke, LY (corresponding author), Kaohsiung Med Univ, Coll Med, Grad Inst Med, Kaohsiung 80708, Taiwan.; Ke, LY (corresponding author), Kaohsiung Med Univ, Drug Dev & Value Creat Res Ctr, Kaohsiung 80708, Taiwan.
EM fparveen.jh@gmail.com; dbender2@gmx.de; shlaw_0909@hotmail.com;
   vineetkmishra.jh@gmail.com; chieh@imst.nsysu.edu.tw; kly@gap.kmu.edu.tw
RI Mishra, Vineet/HSH-2854-2023; Ke, Liang-Yin/A-2778-2009
OI Bender, Daniel/0000-0002-2975-4186; Chen,
   Chih-Chieh/0000-0002-5844-8428; Ke, Liang-Yin/0000-0002-2547-0987
FU Kaohsiung Medical University [KMU-DK108004, KMU-TC108A03-0]; Taiwanese
   Ministry of Science and Technology [107-2911-I-037-505,
   107-2314-B-037-114-MY3, 107-2321-B-037-002-]
FX This work was supported in part by grants from the Kaohsiung Medical
   University (KMU-DK108004, KMU-TC108A03-0) and the Taiwanese Ministry of
   Science and Technology (107-2911-I-037-505, 107-2314-B-037-114-MY3, and
   107-2321-B-037-002-).
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NR 117
TC 102
Z9 109
U1 2
U2 30
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2073-4409
J9 CELLS-BASEL
JI Cells
PD DEC
PY 2019
VL 8
IS 12
AR 1573
DI 10.3390/cells8121573
PG 19
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA KB7AN
UT WOS:000506643500101
PM 31817238
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Gresová, L
   Kvandová, M
   Kvasnicka, P
   Dovinová, I
AF Gresova, Linda
   Kvandova, Miroslava
   Kvasnicka, Peter
   Dovinova, Ima
TI Age-dependent effect of PPARγ agonist pioglitazone on kidney signaling
   in borderline hypertensive rats
SO GENERAL PHYSIOLOGY AND BIOPHYSICS
LA English
DT Article
DE Age-dependence; BHR; Kidney; PPAR gamma; Nrf2; NOS; Hypertension
ID ROSTRAL VENTROLATERAL MEDULLA; ACTIVATED RECEPTOR-GAMMA; PROLIFERATOR;
   STRESS; NRF2
AB The peroxisome proliferator-activated receptor gamma (PPAR gamma) is a nuclear receptor and nutrition factor which takes part in the cellular signaling by several agonists such as pioglitazone. PPAR gamma can serve as potential target in treatments of metabolic syndrome diseases and/or hypertension. In the present study we investigated the effects of pioglitazone, a PPAR gamma agonist, on hypertension development in young and adult borderline hypertensive rats (BHR). In renal signaling we observed connections between PPAR gamma and Nrf2, antioxidant in adult animals and differences between young and adult BHR in Nrf2-activated detoxificant outputs (NQO1, HO-1) and NO-synthases. Blood pressure in animals had been detected by cuff plethysmography, cell signaling in the kidney was studied by gene expression determination using qPCR, and nitric oxide synthase (NOS) activity was measured by radioactive detection. Pioglitazone treatment in adult BHR caused no detectable changes in antioxidant and detoxificant responses. The main effects were observed in blood pressure improvement, endothelial NOS expression and NOS activities in both young and adult BHR.
C1 [Gresova, Linda; Kvandova, Miroslava; Dovinova, Ima] Slovak Acad Sci, Ctr Expt Med, Inst Normal & Pathol Physiol, Sienkiewiczova 1, Bratislava 81371, Slovakia.
   [Kvandova, Miroslava] Johannes Gutenberg Univ Mainz, Univ Med Ctr, Cardiol Lab Mol Cardiol 1, Ctr Cardiol, Mainz, Germany.
   [Kvasnicka, Peter] Charles Univ Prague, Fac Math & Phys, Inst Particle & Nucl Phys, Prague, Czech Republic.
C3 Slovak Academy of Sciences; Institute of Normal & Pathological
   Physiology, SAS; Centre of Experimental Medicine, SAS; Johannes
   Gutenberg University of Mainz; Charles University Prague
RP Dovinová, I (corresponding author), Slovak Acad Sci, Ctr Expt Med, Inst Normal & Pathol Physiol, Sienkiewiczova 1, Bratislava 81371, Slovakia.
OI DOVINOVA, IMA/0000-0001-9840-1950
FU  [VEGA 2/0148/17];  [APVV-0348-12]
FX The study was supported by grants VEGA 2/0148/17 and APVV-0348-12.
CR [Anonymous], CARDIOL LETT
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   [Anonymous], OXID MED CELL LONGEV
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NR 31
TC 2
Z9 2
U1 0
U2 5
PU AEPRESS SRO
PI BRATISLAVA
PA BAJZOVA 7, BRATISLAVA, 821 08, SLOVAKIA
SN 0231-5882
EI 1338-4325
J9 GEN PHYSIOL BIOPHYS
JI Gen. Physiol. Biophys.
PY 2019
VL 38
IS 3
BP 259
EP 264
DI 10.4149/gpb_2019005
PG 6
WC Biochemistry & Molecular Biology; Biophysics; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Physiology
GA IC7NN
UT WOS:000471161600008
PM 31184312
OA gold
DA 2025-06-11
ER

PT J
AU Demirelli, S
   Firtina, S
   Askin, L
   Gur, STA
   Sen Tanrikulu, C
   Ermis, E
   Ipek, E
   Kalkan, K
   Yildirim, E
   Kiziltunc, A
AF Demirelli, Selami
   Firtina, Serdar
   Askin, Lutfu
   Gur, Sultan Tuna Akgol
   Sen Tanrikulu, Ceren
   Ermis, Emrah
   Ipek, Emrah
   Kalkan, Kamuran
   Yildirim, Erkan
   Kiziltunc, Ahmet
TI Utility of γ-Glutamyl Transferase in Predicting Troponin Elevation in
   Emergency Departments
SO ANGIOLOGY
LA English
DT Article
DE chest pain; emergency department; -glutamyl transferase; troponin
ID ACUTE CORONARY SYNDROME; NEUTROPHIL-LYMPHOCYTE RATIO; PROGNOSTIC VALUE;
   CARDIOVASCULAR-DISEASE; MYOCARDIAL-INFARCTION; ARTERY-DISEASE; METABOLIC
   SYNDROME; OXIDATIVE STRESS; HEART-DISEASE; ATHEROSCLEROSIS
AB Serum -glutamyl transferase (GGT) activity is a risk predictor for the development of coronary artery disease and is related to cardiovascular morbidity and mortality. We evaluated the clinical utility of GGT activity in predicting high troponin levels in patients with acute coronary syndrome (ACS) admitted to the emergency department with chest pain. A total of 200 troponin-positive and 203 troponin-negative patients were classified into groups 1 and 2, respectively. -Glutamyl transferase activity was significantly higher in group 1 (44 +/- 34 U/L) compared with group 2 (31 +/- 26 U/L, P = .001). A GGT activity cutoff >25.5 showed 62% sensitivity and 61% specificity in predicting troponin positivity. Logistic regression analysis demonstrated a significant predictive value of GGT for troponin positivity. Spearman rank correlation analysis showed a moderately strong relationship between GGT activity and troponin positivity. Considering the predictive value of high GGT activity for troponin positivity, GGT activity may complement other diagnostic biomarkers for predicting troponin positivity in patients having ACS admitted with chest pain.
C1 [Demirelli, Selami; Ermis, Emrah; Ipek, Emrah; Kalkan, Kamuran; Yildirim, Erkan] Erzurum Educ & Res Hosp, Dept Cardiol, TR-25100 Erzurum, Turkey.
   [Firtina, Serdar] Maresal Cakmak Mil Hosp, Dept Cardiol, Erzurum, Turkey.
   [Askin, Lutfu] Palandoken State Hosp, Dept Cardiol, Erzurum, Turkey.
   [Gur, Sultan Tuna Akgol; Sen Tanrikulu, Ceren] Erzurum Educ & Res Hosp, Dept Emergency Med, Erzurum, Turkey.
   [Kiziltunc, Ahmet] Ataturk Univ, Dept Biochem, Fac Med, Erzurum, Turkey.
C3 Erzurum Bolge Training & Research Hospital; Erzurum Military Hospital;
   Palandoken State Hospital; Erzurum Bolge Training & Research Hospital;
   Ataturk University
RP Demirelli, S (corresponding author), Erzurum Educ & Res Hosp, Dept Cardiol, TR-25100 Erzurum, Turkey.
EM demirelli23@yahoo.com
RI Ermiş, Emrah/ABB-7141-2020; Demirelli, Selami/A-1208-2018; Yıldırım,
   Erkan/Q-9702-2019; İpek, Emrah/HJP-5781-2023; Kalkan,
   Kamuran/HKF-3108-2023; askin, lutfu/H-1047-2018
OI Kalkan, Kamuran/0000-0001-6204-316X; Ermis, Emrah/0000-0001-7292-7516;
   askin, lutfu/0000-0001-7768-2562; Ipek, Emrah/0000-0002-5439-1970
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NR 31
TC 4
Z9 4
U1 0
U2 7
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0003-3197
EI 1940-1574
J9 ANGIOLOGY
JI Angiology
PD SEP
PY 2016
VL 67
IS 8
BP 737
EP 741
DI 10.1177/0003319715613923
PG 5
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA DV3XG
UT WOS:000382857900005
PM 26514415
DA 2025-06-11
ER

PT J
AU Rosa, CDB
   dos Santos, CA
   Leite, JIA
   Caldas, APS
   Bressan, J
AF Barbosa Rosa, Carla de Oliveira
   dos Santos, Carolina Araujo
   Alvarez Leite, Jacqueline Isaura
   Silva Caldas, Ana Paula
   Bressan, Josefina
TI Impact of Nutrients and Food Components on Dyslipidemias: What Is the
   Evidence?
SO ADVANCES IN NUTRITION
LA English
DT Review
DE nutrients; food components; dyslipidemias; cardiovascular disease;
   antioxidants
ID DENSITY-LIPOPROTEIN CHOLESTEROL; RANDOMIZED CONTROLLED-TRIALS; ESTER
   TRANSFER PROTEIN; DISEASE RISK-FACTORS; CARDIOVASCULAR-DISEASE;
   ANTIOXIDANT STATUS; METABOLIC SYNDROME; OXIDATIVE STRESS; LIPID PROFILE;
   BRAZILIAN GUIDELINES
AB Dyslipidemias have been shown to bear a close association with an increased risk of cardiovascular diseases, atherosclerosis in particular. As efforts are being made to find alternative therapies and ways to prevent disease, there is a corresponding rise in public interest in food and/or active food components that contribute to an improved lipid profile and, thus, to better health. Besides supplying the basic nutrients necessary for well-being, some foods add further physiologic benefits. In fact, specific foods and bioactive components could be beneficial in controlling dyslipidemias. From a review of the literature on foods and bioactive compounds, their recommended quantities, and expected effects, we found that the following nutrients and food components could positively impact the lipid profile: monounsaturated and polyunsaturated fatty acids, soluble fiber, vegetable proteins, phytosterols, and polyphenols. Therefore, incorporating these components into the regular diets of individuals is justified, because they contribute additional positive effects. This suggests that they also be recommended in clinical practice.
C1 [Barbosa Rosa, Carla de Oliveira; dos Santos, Carolina Araujo; Silva Caldas, Ana Paula; Bressan, Josefina] Univ Fed Vicosa, Vicosa, MG, Brazil.
   [Alvarez Leite, Jacqueline Isaura] Univ Fed Minas Gerais, Belo Horizonte, MG, Brazil.
C3 Universidade Federal de Vicosa; Universidade Federal de Minas Gerais
RP Rosa, CDB (corresponding author), Univ Fed Vicosa, Vicosa, MG, Brazil.
EM carla.rosa@ufv.br
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NR 85
TC 33
Z9 36
U1 0
U2 24
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 2161-8313
EI 2156-5376
J9 ADV NUTR
JI Adv. Nutr.
PD NOV
PY 2015
VL 6
IS 6
BP 703
EP 711
DI 10.3945/an.115.009480
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA CV8ZQ
UT WOS:000364577400008
PM 26567195
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Zhao, XY
   Wang, JQ
   Neely, GG
   Shi, YC
   Wang, QP
AF Zhao, Xin-Yuan
   Wang, Ji-Qiu
   Neely, G. Gregory
   Shi, Yan-Chuan
   Wang, Qiao-Ping
TI Natural compounds as obesity pharmacotherapies
SO PHYTOTHERAPY RESEARCH
LA English
DT Review
DE energy expenditure; food intake; natural compounds; obesity;
   pharmacotherapies; weight loss efficacy
ID HIGH-FAT DIET; WHITE ADIPOSE-TISSUE; 11-BETA-HYDROXYSTEROID
   DEHYDROGENASE TYPE-1; SUPPRESSES LIPID-ACCUMULATION; IMPROVING
   INSULIN-RESISTANCE; ENDOPLASMIC-RETICULUM STRESS; PROTEIN-KINASE AMPK;
   REDUCES BODY-WEIGHT; GREEN TEA EXTRACT; METABOLIC SYNDROME
AB Obesity has become a serious global public health problem, affecting over 988 million people worldwide. Nevertheless, current pharmacotherapies have proven inadequate. Natural compounds have garnered significant attention due to their potential antiobesity effects. Over the past three decades, ca. 50 natural compounds have been evaluated for the preventive and/or therapeutic effects on obesity in animals and humans. However, variations in the antiobesity efficacies among these natural compounds have been substantial, owing to differences in experimental designs, including variations in animal models, dosages, treatment durations, and administration methods. The feasibility of employing these natural compounds as pharmacotherapies for obesity remained uncertain. In this review, we systematically summarized the antiobesity efficacy and mechanisms of action of each natural compound in animal models. This comprehensive review furnishes valuable insights for the development of antiobesity medications based on natural compounds.
   This review systematically summarizes the preventive and therapeutic effects, and molecular mechanisms of natural compounds on obesity.image
C1 [Zhao, Xin-Yuan; Wang, Qiao-Ping] Sun Yat Sen Univ, Sch Pharmaceut Sci Shenzhen, Lab Metab & Aging, Shenzhen Campus, Shenzhen 518107, Peoples R China.
   [Wang, Ji-Qiu] Shanghai Jiao Tong Univ, Ruijin Hosp, Dept Endocrinol & Metab, Sch Med, Shanghai, Peoples R China.
   [Neely, G. Gregory] Univ Sydney, Charles Perkins Ctr, Dr John & Anne Chong Lab Funct Genom, Sydney, NSW, Australia.
   [Neely, G. Gregory] Univ Sydney, Sch Life & Environm Sci, Sydney, NSW, Australia.
   [Shi, Yan-Chuan] Garvan Inst Med Res, Diabet & Metab Div, Sydney, NSW, Australia.
   [Shi, Yan-Chuan] Univ New South Wales, Fac Med, St Vincents Clin Sch, Sydney, NSW, Australia.
   [Wang, Qiao-Ping] Sun Yat Sen Univ, Affiliated Hosp 3, Med Ctr Comprehens Weight Control, Guangzhou, Peoples R China.
   [Wang, Qiao-Ping] Sun Yat Sen Univ, Affiliated Hosp 3, Guangdong Prov Key Lab Diabetol, Guangzhou Key Lab Mechanist & Translat Obes Res, Guangzhou, Peoples R China.
   [Wang, Qiao-Ping] Sun Yat Sen Univ, Sch Pharmaceut Sci Shenzhen, Lab Metab & Aging, Shenzhen Campus, Shenzhen 518107, Peoples R China.
C3 Sun Yat Sen University; Shanghai Jiao Tong University; University of
   Sydney; University of Sydney; Garvan Institute of Medical Research;
   University of New South Wales Sydney; Sun Yat Sen University; Sun Yat
   Sen University; Sun Yat Sen University
RP Wang, QP (corresponding author), Sun Yat Sen Univ, Sch Pharmaceut Sci Shenzhen, Lab Metab & Aging, Shenzhen Campus, Shenzhen 518107, Peoples R China.
EM wangqp7@mail.sysu.edu.cn
RI Shi, Yanchuan/H-5608-2012; zhao, xinyuan/JAC-3801-2023; zhang,
   hui/GXH-6098-2022; Wang, Qiao-Ping/HPC-0287-2023; Neely, G.
   Gregory/AAB-4642-2020
OI Zhao, Xinyuan/0000-0003-2388-5967; Wang, Qiao-Ping/0000-0003-2809-6457;
   Neely, G. Gregory/0000-0002-1957-9732
FU Natural Science Foundation of China; Natural Science of Foundation of
   Guangdong Province, China [2018B030306002]; Science and Technology
   Innovation Committee of Shenzhen, China [201908073000449]; Fundamental
   Research Funds for the Central Universities; Sun Yat-sen University,
   China [20ykzd18];  [31800993];  [31970934]
FX This work was funded by the Natural Science Foundation of China
   (31800993 and 31970934), Natural Science of Foundation of Guangdong
   Province, China (2018B030306002), Science and Technology Innovation
   Committee of Shenzhen, China (201908073000449), and the Fundamental
   Research Funds for the Central Universities, Sun Yat-sen University,
   China (20ykzd18).
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NR 350
TC 11
Z9 11
U1 10
U2 31
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0951-418X
EI 1099-1573
J9 PHYTOTHER RES
JI Phytother. Res.
PD FEB
PY 2024
VL 38
IS 2
BP 797
EP 838
DI 10.1002/ptr.8083
EA DEC 2023
PG 42
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA HV6V6
UT WOS:001121177400001
PM 38083970
DA 2025-06-11
ER

PT J
AU Serrano, E
   Shenoy, P
   Cantarin, MPM
AF Serrano, Eurico
   Shenoy, Prashamsa
   Cantarin, Maria Paula Martinez
TI Adipose tissue metabolic changes in chronic kidney disease
SO IMMUNOMETABOLISM
LA English
DT Review
DE chronic kidney disease; adipose tissue inflammation; adipokines; chronic
   inflammation; protein energy wasting; insulin resistance; adiponectin;
   leptin
ID ENDOPLASMIC-RETICULUM STRESS; STAGE RENAL-DISEASE; OXIDATION PROTEIN
   PRODUCTS; INSULIN-RESISTANCE; GLUCOSE-UPTAKE; INFLAMMATORY CYTOKINES;
   ENERGY HOMEOSTASIS; HUMAN ADIPOCYTES; UREMIC TOXINS; PLASMA LEPTIN
AB Adipose tissue is a complex organ whose functions go beyond being an energy reservoir to sustain proper body energy homeostasis. Functioning as an endocrine organ, the adipose tissue has an active role in the body's metabolic balance regulation through several secreted factors generally termed as adipokines. Thus, adipose tissue dysregulation in chronic kidney disease (CKD) can have a deep impact in the pathophysiology of diseases associated with metabolic dysregulation including metabolic syndrome, insulin resistance (IR), atherosclerosis, and even cachexia. CKD is a progressive disorder linked to increased morbidity and mortality. Despite being characterized by renal function loss, CKD is accompanied by metabolic disturbances such as dyslipidemia, protein energy wasting, chronic low-grade inflammation, IR, and lipid redistribution. Thus far, the mechanisms by which these changes occur and the role of adipose tissue in CKD development and progression are unclear. Further understanding of how these factors develop could have implications for the management of CKD by helping identify pharmacological targets to improve CKD outcomes.
C1 [Serrano, Eurico; Shenoy, Prashamsa; Cantarin, Maria Paula Martinez] Thomas Jefferson Univ, Sidney Kimmel Med Coll, Dept Med, Div Nephrol, Philadelphia, PA 19144 USA.
C3 Thomas Jefferson University
RP Cantarin, MPM (corresponding author), Thomas Jefferson Univ, Sidney Kimmel Med Coll, Dept Med, Div Nephrol, Philadelphia, PA 19144 USA.
EM maria.p.martinezcantarin@jefferson.edu
OI Serrano, Eurico/0000-0002-5047-164X
FU National Institute of Diabetes and Digestive and Kidney Disease (NIDDK)
   Division of Intramural Research [R01DK111574]
FX The work was primarily funded by the National Institute of Diabetes and
   Digestive and Kidney Disease (NIDDK) Division of Intramural Research
   projects R01DK111574 (to M.P.M.).
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NR 141
TC 9
Z9 10
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 2633-0407
J9 IMMUNOMETABOLISM
JI Immunometabolism
PD APR
PY 2023
VL 5
IS 2
AR e00023
DI 10.1097/IN9.0000000000000023
PG 8
WC Endocrinology & Metabolism; Immunology
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism; Immunology
GA WB1X9
UT WOS:001252328500003
PM 37128293
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Dua, P
   Mishra, A
   Reeta, KH
AF Dua, Pamila
   Mishra, Archana
   Reeta, K. H.
TI Lp-PLA2 as a biomarker and its possible associations with SARS-CoV-2
   infection
SO BIOMARKERS IN MEDICINE
LA English
DT Review
DE biomarker; COVID-19; Lp-PLA2
ID LIPOPROTEIN-ASSOCIATED PHOSPHOLIPASE-A2; ACUTE CORONARY SYNDROME; FUTURE
   CARDIOVASCULAR EVENTS; PLATELET-ACTIVATING-FACTOR; FATTY LIVER-DISEASE;
   A(2) ACTIVITY; VASCULAR INFLAMMATION; RISK-STRATIFICATION; METABOLIC
   SYNDROME; PROGNOSTIC VALUE
AB Lp-PLA2 is an enzyme encoded by the PLA2G7 gene located at chromosome 6p12-21, which is included in different signal transduction pathways. The potential of serum levels of Lp-PLA2 as a marker of inflammation quantifying cardio-metabolic risk, renal impairment and oxidative stress has been explored in earlier studies. It has also been used in chronic obstructive pulmonary disease, hepatic disease, metabolic conditions and exercise tolerance. Additionally, it shows promising evidence for the assessment of risk for certain cardiovascular conditions in otherwise seemingly healthy individuals. COVID-19 has affected life and the economy globally. The identification of biomarkers to assess the sickness and treatment plan is the need of the hour. This review summarizes the pathophysiological inter-relationship between serum levels of Lp-PLA2 and COVID-19. The authors hypothesize that the estimation of Lp-PLA2 levels may help in the early identification of risk and thus may play a beneficial role in the proactive management of COVID-19.
C1 [Dua, Pamila; Mishra, Archana; Reeta, K. H.] All India Inst Med Sci, Dept Pharmacol, New Delhi 110029, India.
C3 All India Institute of Medical Sciences (AIIMS) New Delhi
RP Reeta, KH (corresponding author), All India Inst Med Sci, Dept Pharmacol, New Delhi 110029, India.
EM reetakh@gmail.com
RI Reeta, Kh/AAU-2462-2021
OI DUA, PAMILA/0000-0003-2381-0455; , Archana/0000-0001-8837-299X
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NR 94
TC 9
Z9 11
U1 4
U2 13
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1752-0363
EI 1752-0371
J9 BIOMARK MED
JI Biomark. Med.
PD JUL
PY 2022
VL 16
IS 10
BP 821
EP 832
DI 10.2217/bmm-2021-1129
EA JUN 2022
PG 12
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 2R9YO
UT WOS:000809887000001
PM 35694871
OA Green Published
DA 2025-06-11
ER

PT J
AU Nowotny, K
   Schröter, D
   Schreiner, M
   Grune, T
AF Nowotny, Kerstin
   Schroeter, David
   Schreiner, Monika
   Grune, Tilman
TI Dietary advanced glycation end products and their relevance for human
   health
SO AGEING RESEARCH REVIEWS
LA English
DT Review
DE Advanced glycation end products; Human health; Ageing; Dietary burden
ID MAILLARD REACTION-PRODUCTS; EPSILON-CARBOXYMETHYL-LYSINE; OXIDATIVE
   STRESS; ENDOTHELIAL FUNCTION; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   CROSS-LINKING; SERUM-LEVELS; RISK-FACTOR; IN-VITRO
AB Due to their bioactivity and harmful potential, advanced glycation end products (AGEs) are discussed to affect human health. AGEs are compounds formed endogenously in the human body andexogenously, especially, in foods while thermal processing. In contrast to endogenous AGEs, dietary AGEs are formed in much higher extent. However, their risk potential is also depending on absorption, distribution, metabolism and elimination. For over 10 years an intense debate on the risk of dietary AGEs on human health is going on. On the one hand, studies provided evidence that dietary AGEs contribute to clinical outcomes. On the other hand, human studies failed to observe any association. Because it was not possible to draw a final conclusion, the call for new interdisciplinary approaches arose. In this review, we will give an overview on the current state of scientific knowledge in this field. In particular, we focus on (I) the occurrence of AGEs in foods and the daily uptake of AGEs, (II) contribution to endogenous levels and (III) the effect on health-/disease-related biomarkers in humans.
C1 [Nowotny, Kerstin; Schroeter, David; Grune, Tilman] German Inst Human Nutr Potsdam Rehbruecke DIfE, Dept Mol Toxicol, D-14558 Nuthetal, Germany.
   [Schroeter, David; Schreiner, Monika] Leibniz Inst Vegetable & Ornamental Crops Grossbe, D-14979 Grossbeeren, Germany.
   [Schroeter, David] Univ Hamburg, Inst Food Chem, Hamburg Sch Food Sci, D-20146 Hamburg, Germany.
   [Grune, Tilman] Univ Potsdam, Inst Nutr, D-14558 Nuthetal, Germany.
   [Grune, Tilman] German Ctr Diabet Res DZD, D-85764 Munich, Germany.
   [Grune, Tilman] German Ctr Cardiovasc Res DZHK, D-10117 Berlin, Germany.
   [Schreiner, Monika; Grune, Tilman] NutriAct Competence Cluster Nutr Res Berlin Potsd, D-14458 Nuthetal, Germany.
C3 Leibniz Association; Deutsches Institut fur Ernahrungsforschung
   Potsdam-Rehbrucke (DIfE); Leibniz Association; Leibniz Institut fur
   Gemuse- und Zierpflanzenbau (IGZ); University of Hamburg; German Center
   for Diabetes Research (DZD); German Centre for Cardiovascular Research
RP Grune, T (corresponding author), German Inst Human Nutr Potsdam Rehbrucke, Arthur Scheunert Allee 114-116, D-14558 Nuthetal, Germany.
EM scientiflc.director@dife.de
OI Grune, Tilman/0000-0003-4775-9973; Schreiner,
   Monika/0000-0002-5629-4429; Schroter, David/0000-0001-8296-5620
FU Leibniz Research Alliance "Sustainable Food Production and Healthy
   Nutrition"
FX This work was supported by the Leibniz Research Alliance "Sustainable
   Food Production and Healthy Nutrition" to TG.
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NR 116
TC 186
Z9 196
U1 6
U2 124
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 1568-1637
EI 1872-9649
J9 AGEING RES REV
JI Ageing Res. Rev.
PD NOV
PY 2018
VL 47
BP 55
EP 66
DI 10.1016/j.arr.2018.06.005
PG 12
WC Cell Biology; Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Cell Biology; Geriatrics & Gerontology
GA GZ1MU
UT WOS:000449133000007
PM 29969676
OA hybrid
DA 2025-06-11
ER

PT J
AU Lin, YY
   Lee, SD
AF Lin, Yi-Yuan
   Lee, Shin-Da
TI Cardiovascular Benefits of Exercise Training in Postmenopausal
   Hypertension
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE physical training; heart disease; cardiac remodeling; fibrosis;
   apoptosis
ID BLOOD-PRESSURE; METABOLIC SYNDROME; AEROBIC EXERCISE; ARTERIAL
   STIFFNESS; ESTROGEN; RESISTANCE; MENOPAUSE; STRENGTH; RISK
AB Exercise training is often considered the cornerstone of nonpharmacological therapy for postmenopausal hypertension while aerobic exercise is the mainstay of life style modification for antihypertension. Moderate-intensity aerobic exercise is well tolerated on most days of the week by most people with postmenopausal hypertension and is not suspected to detract from exercise adherence. That being said, moderate aerobic exercise may be superior for eliciting cardiovascular benefits in hypertensive postmenopausal women and resistance exercise may offer desirable benefits. The beneficial outcomes of exercise training for hypertensive postmenopausal women include improvements in blood pressure, autonomic tone, baroreflex sensitivity, oxidative stress, nitric oxide (NO), bioavailability, and lipid profiles, as well as cardiovascular function and cardiorespiratory fitness. This partly explains the fact that exercise training programs have a positive effect for cardiovascular disease in hypertensive postmenopausal women. This review is to collect and present the literature of exercise training in postmenopausal hypertension. Our review may provide the current understanding of beneficial effects and mechanisms of exercise intervention for prevention and treatment of stage 1 to 2 hypertensive postmenopausal women.
C1 [Lin, Yi-Yuan] China Med Univ, Grad Inst Clin Med Sci, Taichung 40402, Taiwan.
   [Lee, Shin-Da] China Med Univ, Grad Inst Rehabil Sci, Dept Phys Therapy, Taichung 40402, Taiwan.
   [Lee, Shin-Da] Asia Univ, Dept Occupat Therapy, Taichung 41354, Taiwan.
   [Lee, Shin-Da] Shanghai Univ Tradit Chinese Med, Sch Rehabil Sci, Shanghai 201203, Peoples R China.
C3 China Medical University Taiwan; China Medical University Taiwan; Asia
   University Taiwan; Shanghai University of Traditional Chinese Medicine
RP Lee, SD (corresponding author), China Med Univ, Grad Inst Rehabil Sci, Dept Phys Therapy, Taichung 40402, Taiwan.; Lee, SD (corresponding author), Asia Univ, Dept Occupat Therapy, Taichung 41354, Taiwan.; Lee, SD (corresponding author), Shanghai Univ Tradit Chinese Med, Sch Rehabil Sci, Shanghai 201203, Peoples R China.
EM charlet8116@gmail.com.tw; shinda@mail.cmu.edu.tw
RI ; Lee, Shin-Da/Q-2798-2015
OI Lin, Yi-Yuan/0000-0002-6147-0183; Lee, Shin-Da/0000-0002-8393-8349
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NR 46
TC 50
Z9 57
U1 1
U2 18
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD SEP
PY 2018
VL 19
IS 9
AR 2523
DI 10.3390/ijms19092523
PG 13
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA HA1OU
UT WOS:000449988100059
PM 30149647
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Sutter, C
   Ontai, LL
   Shilts, MK
   Lanoue, L
   Allen, LH
   Townsend, MS
AF Sutter, Carolyn
   Ontai, Lenna L.
   Shilts, Mical K.
   Lanoue, Louise
   Allen, Lindsay H.
   Townsend, Marilyn S.
TI Associations Between School Readiness and Obesity- and
   Inflammation-Related Biomarkers in Low-Income Preschoolers Within the
   Healthy Kids Study
SO MIND BRAIN AND EDUCATION
LA English
DT Article
ID EARLY-LIFE ADVERSITY; RESULTS DEVELOPMENTAL PROFILE; GRADE SYSTEMIC
   INFLAMMATION; BODY-MASS INDEX; ACADEMIC-PERFORMANCE; UNITED-STATES;
   BEHAVIOR QUESTIONNAIRE; OVERWEIGHT CHILDREN; COGNITIVE FUNCTION;
   METABOLIC SYNDROME
AB Previous research suggests obesity is negatively related to cognitive functioning and academic outcomes in addition to physical health. However, not much is known about this association in early childhood or potential physiological underpinnings. Biomarkers related to obesity have been associated with cognition, in particular the adipokine leptin, and pro-inflammatory cytokines including interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha) and C-reactive protein (CRP). These associations may be further exacerbated for children who experience early life stress. With a sample of low-income preschoolers, the current study examined associations between obesity-related biomarkers and aspects of behavioral and cognitive school readiness. Partial correlations controlling for child age show hypothesized negative associations between pro-inflammatory cytokines and school readiness, while leptin was positively associated with cognitive school readiness and body mass index (BMI) z-score. Findings suggest connections between obesity, physiology, and school readiness need further examination, but may have implications for early childhood education and health interventions.
C1 [Sutter, Carolyn] Univ Illinois, Family Resiliency Ctr, Urbana, IL 61801 USA.
   [Ontai, Lenna L.] Univ Calif Davis, Dept Human Ecol, Davis, CA 95616 USA.
   [Shilts, Mical K.] Calif State Univ Sacramento, Dept Family & Consumer Studies, Sacramento, CA 95819 USA.
   [Lanoue, Louise; Townsend, Marilyn S.] Univ Calif Davis, Dept Nutr, Davis, CA 95616 USA.
   [Allen, Lindsay H.] ARS, Western Human Nutr Res Ctr, USDA, Washington, DC USA.
C3 University of Illinois System; University of Illinois Urbana-Champaign;
   University of California System; University of California Davis;
   California State University System; California State University
   Sacramento; University of California System; University of California
   Davis; United States Department of Agriculture (USDA)
RP Sutter, C (corresponding author), Univ Illinois, Family Resiliency Ctr, Urbana, IL 61801 USA.
EM carolyns@illinois.edu
RI Sutter, Carolyn/J-8593-2019
OI Sutter, Carolyn/0000-0001-8448-2251; Ontai, Lenna/0000-0002-1644-2888
FU U.S. Department of Agriculture, National Institute of Food and
   Agriculture
FX This research was funded by the U.S. Department of Agriculture, National
   Institute of Food and Agriculture.
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   [No title captured]
NR 48
TC 1
Z9 3
U1 1
U2 17
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1751-2271
EI 1751-228X
J9 MIND BRAIN EDUC
JI Mind Brain Educ.
PD MAR
PY 2018
VL 12
IS 1
BP 28
EP 38
DI 10.1111/mbe.12165
PG 11
WC Education & Educational Research; Psychology, Developmental
WE Social Science Citation Index (SSCI)
SC Education & Educational Research; Psychology
GA GM8UH
UT WOS:000438510600004
DA 2025-06-11
ER

PT J
AU Bandini, M
   Gandaglia, G
   Briganti, A
AF Bandini, Marco
   Gandaglia, Giorgio
   Briganti, Alberto
TI Obesity and prostate cancer
SO CURRENT OPINION IN UROLOGY
LA English
DT Review
DE body mass index; obesity; prostate cancer; upgrade; upstage
ID BODY-MASS INDEX; ANDROGEN DEPRIVATION THERAPY; RADICAL PROSTATECTOMY;
   BIOCHEMICAL RECURRENCE; METABOLIC SYNDROME; ADIPOSE-TISSUE; ANTIGEN
   LEVELS; LIFE-STYLE; RISK; IMPACT
AB Purpose of review
   To investigate the association between obesity and prostate cancer (PCa).
   Recent findings
   Obesity has been proposed to be involved in the pathogenesis of PCa through different biological mechanisms that include deregulation of the insulin axis, sex hormone secretion, adipokines signaling, and oxidative stress. Hypertrophic peritumoral adipocytes may also facilitate the local spread of PCa through the chemo-attraction of tumor cells. Clinical studies demonstrate that obesity might have clinical implications also in disease detection and management. Obese men have been shown to be less likely to be diagnosed with early-stage disease. Moreover, they are at increased risk of experiencing upgrading and upstaging when managed with active surveillance. However, the association between obesity and the risk of PCa recurrence and mortality after radical treatment is still debated.
   Summary
   Obesity may facilitate the development and progression of PCa trough different biologic mechanisms that may pose obese men at higher risk of advanced and high-grade disease. However, the association between obesity and long-term oncologic outcome after radical treatments appears unclear.
C1 [Bandini, Marco; Gandaglia, Giorgio; Briganti, Alberto] IRCCS Hosp San Raffaele, URI, Unit Urol, Div Oncol, I-20131 Milan, Italy.
   [Bandini, Marco; Gandaglia, Giorgio; Briganti, Alberto] Univ Vita Salute San Raffaele, Milan, Italy.
C3 Vita-Salute San Raffaele University; IRCCS Ospedale San Raffaele;
   Vita-Salute San Raffaele University
RP Briganti, A (corresponding author), IRCCS Hosp San Raffaele, URI, Unit Urol, Div Oncol, I-20131 Milan, Italy.
EM briganti.alberto@hsr.it
RI Gandaglia, Giorgio/ABP-8940-2022; Bandini, Marco/AGN-2010-2022;
   Briganti, Alberto/AAN-1965-2020
OI Bandini, Marco/0000-0002-1462-1698
CR [Anonymous], UROL ONCOL
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NR 61
TC 45
Z9 48
U1 0
U2 12
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0963-0643
EI 1473-6586
J9 CURR OPIN UROL
JI Curr. Opin. Urol.
PD SEP
PY 2017
VL 27
IS 5
BP 415
EP 421
DI 10.1097/MOU.0000000000000424
PG 7
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA FB9OR
UT WOS:000406469100003
PM 28632505
DA 2025-06-11
ER

PT J
AU Bo, S
   Milanesio, N
   Schiavone, C
   Villois, P
   Durazzo, M
   Gentile, L
   Cassader, M
   Cavallo-Perin, P
AF Bo, Simona
   Milanesio, Nadia
   Schiavone, Claudia
   Villois, Paola
   Durazzo, Marilena
   Gentile, Luigi
   Cassader, Maurizio
   Cavallo-Perin, Paolo
TI Magnesium and trace element intake after a lifestyle intervention
SO NUTRITION
LA English
DT Article
DE Trace elements; Magnesium; Lifestyle intervention; Metabolic syndrome;
   Glucose
ID INSULIN SENSITIVITY; SUPPLEMENTATION; ZINC; DIETARY; COPPER
AB Objective: Observational studies suggest that some trace elements and magnesium (Mg) improve glucose metabolism, markers of inflammation, and oxidative stress, but supplementation studies have yielded inconsistent results. Our objective was to evaluate whether a lifestyle intervention trial, aimed at reducing total and saturated fat and increasing fiber intake, can affect also the intake of selenium (Se), zinc (Zn), copper (Cu), chromium (Cr), and Mg.
   Methods: Dietary intake of Se, Cr, Zn, Cu, and Mg was evaluated at baseline and at the end of a lifestyle intervention trial performed in 335 dysmetabolic adults.
   Results: At baseline, trace element and Mg intake in the intervention (n = 169) and control (n = 166) groups of the trial were not significantly different. The former significantly increased their intake of Se, Mg, and Cr, while the latter reduced the intake of Mg, Zn, and Cr. Between-group differences were significant for Mg, Cr, and Se.
   Conclusion: Healthier lifestyle recommendations might improve the pattern of micronutrient and Mg intake, which might play an independent role in ameliorating some metabolic, inflammatory, and oxidative markers. (C) 2011 Elsevier Inc. All rights reserved.
C1 [Bo, Simona; Milanesio, Nadia; Schiavone, Claudia; Villois, Paola; Durazzo, Marilena; Cassader, Maurizio; Cavallo-Perin, Paolo] Univ Turin, Dept Internal Med, Turin, Italy.
   [Gentile, Luigi] Hosp Asti, Diabet Clin, Asti, Italy.
C3 University of Turin
RP Bo, S (corresponding author), Univ Turin, Dept Internal Med, Turin, Italy.
EM sbo@molinette.piemonte.it
RI Bo, Simona/AAC-1110-2019
OI Bo, Simona/0000-0001-6862-8628; DURAZZO, Marilena/0000-0003-2450-5911
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NR 11
TC 5
Z9 5
U1 0
U2 4
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0899-9007
EI 1873-1244
J9 NUTRITION
JI Nutrition
PD JAN
PY 2011
VL 27
IS 1
BP 108
EP 110
DI 10.1016/j.nut.2010.04.005
PG 3
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 699JM
UT WOS:000285659700017
PM 20621449
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Khalil, M
   Caponio, GR
   Diab, F
   Shanmugam, H
   Di Ciaula, A
   Khalifeh, H
   Vergani, L
   Calasso, M
   De Angelis, M
   Portincasa, P
AF Khalil, Mohamad
   Caponio, Giusy Rita
   Diab, Farah
   Shanmugam, Harshitha
   Di Ciaula, Agostino
   Khalifeh, Hala
   Vergani, Laura
   Calasso, Maria
   De Angelis, Maria
   Portincasa, Piero
TI Unraveling the beneficial effects of herbal Lebanese mixture "Za'atar".
   History, studies, and properties of a potential healthy food ingredient
SO JOURNAL OF FUNCTIONAL FOODS
LA English
DT Article
DE Biological activities; Gut microbiota; Metabolic syndrome;
   Nutraceutical; Phenolic compounds; Za 'atar
ID VIRGIN OLIVE OIL; CARDIOVASCULAR RISK-FACTORS; SUMAC RHUS-CORIARIA;
   ROSMARINIC ACID; ORIGANUM-SYRIACUM; SESAME OIL; IN-VITRO;
   CHEMICAL-COMPOSITION; ANTIOXIDANT ACTIVITY; OXIDATIVE STRESS
AB Interest in plant-based food has grown in recent years due to their primary prevention potential. Za'atar, an ancient and popular Lebanese herbal mixture, might disclose relevant clinical interest, due to the well-known intrinsic properties of its individual components. Za'atar mixture contain Origanum syriacum (Lebanese thyme), Thymbra spicata (Wild thyme), Rhus coriaria (Sumac), and Sesamum indicum (Sesame). Here we explored the history, composition, general employment, and bio-active aspects of Za'atar through available in vitro, animal, and clinical trials evidence to depict its possible role as an innovative nutraceutical tool. The combined action of Za'atar constituents is able to generate comprehensive beneficial effects on several common pathogenic pathways underlying chronic cardio-metabolic diseases and cancer. However, main available evidence derives from animal and in vitro studies. Thus, further human studies are needed to fully characterize Za'atar as a preventive and curative tool.
C1 [Khalil, Mohamad; Caponio, Giusy Rita; Shanmugam, Harshitha; Di Ciaula, Agostino; Portincasa, Piero] Univ Bari, Dept Biomed Sci & Human Oncol, Clin Med A Murri, Med Sch, Piazza Giulio Cesare 11, I-70124 Bari, Italy.
   [Khalil, Mohamad; Diab, Farah; Vergani, Laura] Univ Genoa, Dept Earth Environm & Life Sci DISTAV, Corso Europa 26, I-16132 Genoa, Italy.
   [Khalil, Mohamad; Caponio, Giusy Rita; Shanmugam, Harshitha; Calasso, Maria; De Angelis, Maria] Univ Bari Aldo Moro, Dept Soil Plant & Food Sci, Via Amendola 165-a, I-70126 Bari, Italy.
   [Khalil, Mohamad; Khalifeh, Hala] Lebanese Univ, Fac Sci, Dept Biol, Lab Rammal Rammal ATAC, Hadath Campus, Beirut, Lebanon.
C3 Universita degli Studi di Bari Aldo Moro; University of Genoa;
   Universita degli Studi di Bari Aldo Moro; Lebanese University
RP Portincasa, P (corresponding author), Univ Bari, Dept Biomed Sci & Human Oncol, Clin Med A Murri, Med Sch, Piazza Giulio Cesare 11, I-70124 Bari, Italy.
EM piero.portincasa@uniba.it
RI Di Ciaula, Agostino/AAW-3499-2021; Khalil, Mohamad/ISA-5550-2023; De
   Angelis, Maria/AAA-9909-2019; Vergani, Laura/AAS-2711-2020; Shanmugam,
   Harshitha/LCE-0958-2024; portincasa, piero/J-7245-2018; Caponio, Giusy
   Rita/AAA-3053-2021
OI Diab, Farah/0000-0002-4488-5547; Caponio, Giusy
   Rita/0000-0001-5446-5776; De Angelis, Maria/0000-0002-2010-884X
FU European Union [722,619]; H2020-MSCA-RISE-2016/H2020-MSCA-RISE-2016
   Grant [734,719]; Foie Gras Early Research Training Grant; project
   SYSTEMIC "an integrated approach to the challenge of sustainable food
   systems: adaptive and mitigatory strategies to address climate change
   and malnutrition", Knowledge hub on Nutrition and Food Security; France
   (INRA); Germany (BLE); Italy (MIPAAF); Latvia (IZM); Norway (RCN);
   Portugal (FCT); Spain (AEI); Belgium (FWO); ERANET ERA-HDHL [696295]
FX The present work is written in the context of the project FOIE GRAS,
   which has received funding from the European Union's Horizon 2020
   Research and Innovation framework, under the Marie Sklodowska-Curie
   Grant Agreement No. 722,619 (P.P.) and the mitoFOIE GRAS funded by
   H2020-MSCA-RISE-2016/H2020-MSCA-RISE-2016 Grant Agreement No. 734,719
   (P.P.). H.S. is recipients of Foie Gras Early Research Training Grant.
   This research received funding from the project SYSTEMIC "an integrated
   approach to the challenge of sustainable food systems: adaptive and
   mitigatory strategies to address climate change and malnutrition",
   Knowledge hub on Nutrition and Food Security, has received funding from
   national research funding parties in Belgium (FWO), France (INRA),
   Germany (BLE), Italy (MIPAAF), Latvia (IZM), Norway (RCN), Portugal
   (FCT), and Spain (AEI) in a joint action of JPI HDHL, JPI-OCEANS, and
   FACCE-JPI launched in 2019 under the ERANET ERA-HDHL (n. 696295).
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NR 191
TC 17
Z9 19
U1 1
U2 13
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1756-4646
EI 2214-9414
J9 J FUNCT FOODS
JI J. Funct. Food.
PD MAR
PY 2022
VL 90
AR 104993
DI 10.1016/j.jff.2022.104993
EA FEB 2022
PG 20
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA ZY3BQ
UT WOS:000772463100010
OA gold
DA 2025-06-11
ER

PT J
AU Ribeiro, IC
   Aranda, LC
   Freitas, TO
   Degani-Costa, LH
   Ferreira, EVM
   Nery, LE
   Silva, BM
AF Ribeiro, Indyanara C.
   Aranda, Liliane C.
   Freitas, Tiago O.
   Degani-Costa, Luiza H.
   Ferreira, Eloara V. M.
   Nery, Luiz E.
   Silva, Bruno M.
TI Intercostal and vastus lateralis microcirculatory response to a
   sympathoexcitatory manoeuvre in patients with chronic obstructive
   pulmonary disease
SO RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
LA English
DT Article
DE Perfusion; Vascular resistance; Skeletal muscle; Vasoconstriction;
   Sympathetic
ID SYMPATHETIC-NERVE ACTIVITY; ENDOTHELIAL DYSFUNCTION; METABOLIC SYNDROME;
   MENTAL STRESS; BLOOD-FLOW; EXERCISE; REPRODUCIBILITY; VALIDATION;
   HYPEREMIA; ROLES
AB Patients with COPD present with systemic vascular malfunctioning and their microcirculation is possibly more fragile to overcome an increase in the sympathetic vasoconstrictor outflow during sympathoexcitatory situations. To test the skeletal muscle microvascular responsiveness to sympathoexcitation, we asked patients with COPD and age- and sex-matched controls to immerse a hand in iced water [Cold Pressor Test (CPT)]. Near-infrared spectroscopy detection of the indocyanine green dye in the intercostal and vastus lateralis microcirculation provided a blood flow index (BFI). BFI divided by mean blood pressure (MBP) provided an index of microvascular conductance (BFI/MBP). The CPT decreased BFI and BFI/MBP in the intercostal (P = 0.01 and < 0.01, respectively) and vastus lateralis (P = 0.08 and 0.03, respectively) only in the COPD group, and the per cent BFI and BFI/MBP decrease was similar between muscles (P = 0.78 and 0.85, respectively). Thus, our findings support that sympathoexcitation similarly impairs intercostal and vastus lateralis microvascular regulation in patients with COPD.
C1 [Ribeiro, Indyanara C.; Aranda, Liliane C.; Freitas, Tiago O.; Degani-Costa, Luiza H.; Ferreira, Eloara V. M.; Nery, Luiz E.; Silva, Bruno M.] Fed Univ Sao Paulo UNIFESP, Div Resp Med, Sao Paulo, SP, Brazil.
   [Silva, Bruno M.] Univ Fed Sao Paulo, Dept Physiol, Sao Paulo, SP, Brazil.
C3 Universidade Federal de Sao Paulo (UNIFESP); Universidade Federal de Sao
   Paulo (UNIFESP)
RP Silva, BM (corresponding author), Botucatu St 862,Biomed Sci Bldg,5th Floor, BR-04023062 Sao Paulo, SP, Brazil.
EM silva.bruno@unifesp.br
RI Falcao, Luiza/T-2207-2019; Ribeiro, Indyanara/ABC-9008-2020; Nery,
   Luiz/O-6844-2019; Ferreira, Eloara/ABA-4719-2021; Silva,
   Bruno/F-7781-2010
OI Ferreira, Eloara/0000-0002-3291-6473; Silva, Bruno/0000-0003-0473-3706;
   Ribeiro, Indyanara Cristina/0000-0001-6317-3361
FU FAPESP [17/07771-3, 18/03501 4]; CNPq [310,110/2019-0, 301,475/2015-6];
   CAPES; Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
   [17/07771-3, 18/03501-4] Funding Source: FAPESP
FX FAPESP: grant to BMS (17/07771-3) and scholarship to ICR (18/03501 4) .
   CNPq: scholarship to ICR and research productivity award to BMS
   (310,110/20190) and LEN (301,475/20156) . CAPES: scholarships to LCA and
   TOF.
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NR 34
TC 5
Z9 5
U1 1
U2 3
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1569-9048
EI 1878-1519
J9 RESP PHYSIOL NEUROBI
JI Respir. Physiol. Neuro.
PD AUG
PY 2021
VL 290
AR 103678
DI 10.1016/j.resp.2021.103678
EA MAY 2021
PG 7
WC Physiology; Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology; Respiratory System
GA SI6QR
UT WOS:000654953300005
PM 33957298
OA Bronze
DA 2025-06-11
ER

PT J
AU Sakurai, Y
   Kubota, N
   Yamauchi, T
   Kadowaki, T
AF Sakurai, Yoshitaka
   Kubota, Naoto
   Yamauchi, Toshimasa
   Kadowaki, Takashi
TI Role of Insulin Resistance in MAFLD
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE NAFLD; MAFLD; insulin signaling; insulin resistance; de novo lipogenesis
   (DNL); triglycerides (TG); diacylglycerol (DAG); lipid metabolism
AB Many studies have reported that metabolic dysfunction is closely involved in the complex mechanism underlying the development of non-alcoholic fatty liver disease (NAFLD), which has prompted a movement to consider renaming NAFLD as metabolic dysfunction-associated fatty liver disease (MAFLD). Metabolic dysfunction in this context encompasses obesity, type 2 diabetes mellitus, hypertension, dyslipidemia, and metabolic syndrome, with insulin resistance as the common underlying pathophysiology. Imbalance between energy intake and expenditure results in insulin resistance in various tissues and alteration of the gut microbiota, resulting in fat accumulation in the liver. The role of genetics has also been revealed in hepatic fat accumulation and fibrosis. In the process of fat accumulation in the liver, intracellular damage as well as hepatic insulin resistance further potentiates inflammation, fibrosis, and carcinogenesis. Increased lipogenic substrate supply from other tissues, hepatic zonation of Irs1, and other factors, including ER stress, play crucial roles in increased hepatic de novo lipogenesis in MAFLD with hepatic insulin resistance. Herein, we provide an overview of the factors contributing to and the role of systemic and local insulin resistance in the development and progression of MAFLD.
C1 [Sakurai, Yoshitaka; Kubota, Naoto; Yamauchi, Toshimasa] Univ Tokyo, Grad Sch Med, Dept Diabet & Metab Dis, Tokyo 1138655, Japan.
   [Kubota, Naoto] Univ Tokyo, Dept Clin Nutr Therapy, Tokyo 1138655, Japan.
   [Kubota, Naoto] Natl Inst Biomed Innovat Hlth & Nutr, Clin Nutr Program, Osaka 5670085, Japan.
   [Kadowaki, Takashi] Toranomon Gen Hosp, Tokyo 1058470, Japan.
C3 University of Tokyo; University of Tokyo; Toranomon Hospital
RP Kubota, N (corresponding author), Univ Tokyo, Grad Sch Med, Dept Diabet & Metab Dis, Tokyo 1138655, Japan.; Kubota, N (corresponding author), Univ Tokyo, Dept Clin Nutr Therapy, Tokyo 1138655, Japan.; Kubota, N (corresponding author), Natl Inst Biomed Innovat Hlth & Nutr, Clin Nutr Program, Osaka 5670085, Japan.; Kadowaki, T (corresponding author), Toranomon Gen Hosp, Tokyo 1058470, Japan.
EM sakuraichin-tky@umin.ac.jp; nkubota-tky@umin.ac.jp; tyamau-tky@umin.net;
   t-kadowaki@toranomon.kkr.or.jp
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NR 187
TC 240
Z9 258
U1 13
U2 76
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD APR
PY 2021
VL 22
IS 8
AR 4156
DI 10.3390/ijms22084156
PG 26
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA RT3FV
UT WOS:000644349000001
PM 33923817
OA Green Published, gold
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Kwon, SY
   Massey, K
   Watson, MA
   Hussain, T
   Volpe, G
   Buckley, CD
   Nicolaou, A
   Badenhorst, P
AF Kwon, So Yeon
   Massey, Karen
   Watson, Mark A.
   Hussain, Tayab
   Volpe, Giacomo
   Buckley, Christopher D.
   Nicolaou, Anna
   Badenhorst, Paul
TI Oxidised metabolites of the omega-6 fatty acid linoleic acid activate
   dFOXO
SO LIFE SCIENCE ALLIANCE
LA English
DT Article
ID INSULIN-RESISTANCE; OXIDATIVE STRESS; LIPID DROPLETS; DROSOPHILA;
   MYELOPEROXIDASE; TRANSCRIPTION; RECEPTOR; GENES; FOXO; CYCLOOXYGENASE
AB Obesity-induced inflammation, or meta-inflammation, plays key roles in metabolic syndrome and is a significant risk factor in diabetes and cardiovascular disease. To investigate causal links between obesity, meta-inflammation, and insulin signaling we established a Drosophila model to determine how elevated dietary fat and changes in the levels and balance of saturated fatty acids (SFAs) and polyunsaturated fatty acids (PUFAs) influence inflammation. We observe negligible effect of saturated fatty acid on inflammation but marked enhancement or suppression by omega-6 and omega-3 PUFAs, respectively. Using combined lipidomic and genetic analysis, we show omega-6 PUFA enhances meta-inflammation by producing linoleic acid-derived lipid mediator 9-hydroxy-octadecadienoic acid (9-HODE). Transcriptome analysis reveals 9-HODE functions by regulating FOXO family transcription factors. We show 9-HODE activates JNK, triggering FOXO nuclear localisation and chromatin binding. FOXO TFs are important transducers of the insulin signaling pathway that are normally down-regulated by insulin. By activating FOXO, 9-HODE could antagonise insulin signaling providing a molecular conduit linking changes in dietary fatty acid balance, meta-inflammation, and insulin resistance.
C1 [Kwon, So Yeon; Watson, Mark A.; Hussain, Tayab; Volpe, Giacomo; Badenhorst, Paul] Univ Birmingham, Inst Canc & Genom Sci, Edgbaston, England.
   [Massey, Karen; Nicolaou, Anna] Univ Bradford, Bradford Sch Pharm, Bradford, W Yorkshire, England.
   [Buckley, Christopher D.] Queen Elizabeth Hosp, Ctr Translat Inflammat Res, Inst Inflammat & Ageing, Edgbaston, England.
   [Buckley, Christopher D.] Univ Oxford, Kennedy Inst Rheumatol, Oxford, England.
   [Nicolaou, Anna] Manchester Acad Hlth Sci Ctr, Fac Biol Med & Hlth, Div Pharm & Optometry, Lab Lipid & Lipid Biol, Manchester, Lancs, England.
   [Massey, Karen] BASF Pharma, Isle Of Lewis, Scotland.
   [Watson, Mark A.] Buck Inst Res Aging, Novato, CA USA.
   [Volpe, Giacomo] Guangzhou Inst Biomed & Hlth, Joint Sch Life Sci, Key Lab Regenerat Biol, Guangzhou, Peoples R China.
C3 University of Birmingham; University of Bradford; University of
   Birmingham; University of Oxford; Kennedy Institute for Rheumatology;
   University of Manchester; BASF; Buck Institute for Research on Aging;
   Chinese Academy of Sciences; Guangzhou Institute of Biomedicine &
   Health, CAS
RP Badenhorst, P (corresponding author), Univ Birmingham, Inst Canc & Genom Sci, Edgbaston, England.
EM p.w.badenhorst@bham.ac.uk
RI Volpe, Giacomo/AAT-2783-2020; Nicolaou, Anna/D-4025-2018; Buckley,
   Christopher Dominic/AAN-6378-2021
OI /0000-0002-2542-0250; Nicolaou, Anna/0000-0002-1314-413X; Volpe,
   Giacomo/0000-0001-5000-6951; Buckley, Christopher
   Dominic/0000-0001-6924-6402
FU BBSRC [BB/M028054/1, BB/P021816/1] Funding Source: UKRI
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PU LIFE SCIENCE ALLIANCE LLC
PI COLD SPRING HARBOR
PA 1 BUNGTOWN RD, COLD SPRING HARBOR, NY 11724 USA
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PD FEB
PY 2020
VL 3
IS 2
AR e201900356
DI 10.26508/lsa.201900356
PG 17
WC Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics
GA KS7BX
UT WOS:000518462300002
PM 31992650
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Benameur, T
   Osman, A
   Parray, A
   Hssain, AA
   Munusamy, S
   Agouni, A
AF Benameur, Tarek
   Osman, Aisha
   Parray, Aijaz
   Hssain, Ali Ait
   Munusamy, Shankar
   Agouni, Abdelali
TI Molecular Mechanisms Underpinning Microparticle-Mediated Cellular Injury
   in Cardiovascular Complications Associated with Diabetes
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Review
ID CIRCULATING ENDOTHELIAL MICROPARTICLES; PLATELET-DERIVED MICROPARTICLE;
   ENDOPLASMIC-RETICULUM STRESS; SHED MEMBRANE MICROPARTICLES; ACUTE
   CORONARY SYNDROME; FLOW-CYTOMETRY; TISSUE-FACTOR; METABOLIC SYNDROME;
   PROGENITOR CELLS; PLASMA-MEMBRANE
AB Microparticles (MPs) are small vesicles shed from the cytoplasmic membrane of healthy, activated, or apoptotic cells. MPs are very heterogeneous in size (100-1,000 nm), and they harbor proteins and surface antigens specific to cells they originate from. Virtually, all cells can shed MPs, and therefore, they can be found in all body fluids, but also entrapped in tissues. Of interest and because of their easy detection using a variety of techniques, circulating MPs were recognized as biomarkers for cell activation. MPs were also found to mediate critical actions in intercellular communication and transmitting biological messages by acting as paracrine vehicles. High plasma numbers of MPs were reported in many cardiovascular and metabolic disturbances that are closely associated with insulin resistance and low-grade inflammation and have been linked to adverse actions on cardiovascular function. This review highlights the involvement of MPs in cardiovascular complications associated with diabetes and discusses the molecular mechanisms that underpin the pathophysiological role of MPs in the onset and progression of cellular injury in diabetes.
C1 [Benameur, Tarek] King Faisal Univ, Coll Med, POB 400, Al Hasa, Saudi Arabia.
   [Osman, Aisha; Agouni, Abdelali] Qatar Univ, Dept Pharmaceut Sci, Coll Pharm, POB 2713, Doha, Qatar.
   [Parray, Aijaz] Hamad Med Corp, Neurosci Inst, Stroke Program, POB 3050, Doha, Qatar.
   [Hssain, Ali Ait] Hamad Med Corp, Med Intens Care Unit, ECMO Team, POB 3050, Doha, Qatar.
   [Munusamy, Shankar] Drake Univ, Dept Pharmaceut & Adm Sci, Coll Pharm & Hlth Sci, Des Moines, IA 50311 USA.
C3 King Faisal University; Qatar University; Hamad Medical Corporation;
   Hamad Medical Corporation; Drake University
RP Agouni, A (corresponding author), Qatar Univ, Dept Pharmaceut Sci, Coll Pharm, POB 2713, Doha, Qatar.
EM aagouni@qu.edu.qa
RI BENAMEUR, T/KIH-8629-2024; Agouni, Abdelali/AAP-5298-2020; Munusamy,
   Shankar/D-6474-2014
OI Agouni, Abdelali/0000-0002-8363-1582; Munusamy,
   Shankar/0000-0002-2023-7705; AIT HSSAIN, Ali/0000-0002-7764-5793
FU NPRP award from Qatar National Research Fund (a member of Qatar
   Foundation) [NPRP8-1750-3-360]; Qatar University high collaborative
   grant [QUCG-CPH-2018\2019-2]; Qatar National Library
FX The figure in this article was partly produced by adapting freely
   available tools from Servier Medical Art, which are licensed under a
   Creative Commons Attribution 3.0 Unported License
   (https://creativecommons.org/licenses/by/3.0/). This work was supported
   by a NPRP award (NPRP8-1750-3-360) from Qatar National Research Fund (a
   member of Qatar Foundation) and a Qatar University high collaborative
   grant (QUCG-CPH-2018\2019-2) to Dr. Abdelali Agouni. The publication of
   this article was funded by Qatar National Library.
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NR 158
TC 17
Z9 18
U1 2
U2 9
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PY 2019
VL 2019
AR 6475187
DI 10.1155/2019/6475187
PG 23
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA HN6BG
UT WOS:000460269000001
PM 30915196
OA Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Grohmann, M
   Wiede, F
   Dodd, GT
   Gurzov, EN
   Ooi, GJ
   Butt, T
   Rasmiena, AA
   Kaur, S
   Gulati, T
   Goh, PK
   Treloar, AE
   Archer, S
   Brown, WA
   Muller, M
   Watt, MJ
   Ohara, O
   McLean, CA
   Tiganis, T
AF Grohmann, Marcus
   Wiede, Florian
   Dodd, Garron T.
   Gurzov, Esteban N.
   Ooi, Geraldine J.
   Butt, Tariq
   Rasmiena, Aliki A.
   Kaur, Supreet
   Gulati, Twishi
   Goh, Pei K.
   Treloar, Aislinn E.
   Archer, Stuart
   Brown, Wendy A.
   Muller, Mathias
   Watt, Matthew J.
   Ohara, Osamu
   McLean, Catriona A.
   Tiganis, Tony
TI Obesity Drives STAT-1-Dependent NASH and STAT-3-Dependent HCC
SO CELL
LA English
DT Article
ID FATTY LIVER-DISEASE; PROTEIN-TYROSINE-PHOSPHATASE;
   HEPATOCELLULAR-CARCINOMA; NONALCOHOLIC STEATOHEPATITIS; CHEMICAL
   HEPATOCARCINOGENESIS; INSULIN SENSITIVITY; METABOLIC SYNDROME; CANCER;
   ACTIVATION; CELLS
AB Obesity is a major driver of cancer, especially hepatocellular carcinoma (HCC). The prevailing view is that non-alcoholic steatohepatitis (NASH) and fibrosis or cirrhosis are required for HCC in obesity. Here, we report that NASH and fibrosis and HCC in obesity can be dissociated. We show that the oxidative hepatic environment in obesity inactivates the STAT-1 and STAT-3 phosphatase T cell protein tyrosine phosphatase (TCPTP) and increases STAT-1 and STAT-3 signaling. TCPTP deletion in hepatocytes promoted T cell recruitment and ensuing NASH and fibrosis as well as HCC in obese C57BU 6 mice that normally do not develop NASH and fibrosis or HCC. Attenuating the enhanced STAT-1 signaling prevented T cell recruitment and NASH and fibrosis but did not prevent HCC. By contrast, correcting STAT-3 signaling prevented HCC without affecting NASH and fibrosis. TCPTP-deletion in hepatocytes also markedly accelerated HCC in mice treated with a chemical carcinogen that promotes HCC without HASH and fibrosis. Our studies reveal how obisity-associated hepatic oxidative stress can independently contribute to the pathogenesis of NASH, fibrosis, and HCC.
C1 [Grohmann, Marcus; Wiede, Florian; Dodd, Garron T.; Gurzov, Esteban N.; Butt, Tariq; Kaur, Supreet; Goh, Pei K.; Archer, Stuart; Watt, Matthew J.; Tiganis, Tony] Monash Univ, Monash Biomed Discovery Inst, Clayton, Vic 3800, Australia.
   [Wiede, Florian; Rasmiena, Aliki A.; Gulati, Twishi; Goh, Pei K.; Treloar, Aislinn E.; Tiganis, Tony] Peter MacCallum Canc Ctr, Melbourne, Vic 3000, Australia.
   [Ooi, Geraldine J.; Brown, Wendy A.] Monash Univ, Alfred Hosp, Dept Surg, Melbourne, Vic 3004, Australia.
   [Muller, Mathias] Univ Vet Med Vienna, Inst Anim Breeding & Genet, Vienna, Austria.
   [Ohara, Osamu] RIKEN Ctr Integrat Med Sci, Yokohama, Kanagawa 2300045, Japan.
   [McLean, Catriona A.] Alfred Hosp, Anat Pathol, Prahran, Vic 3004, Australia.
   [Archer, Stuart] Monash Univ, Monash Bioinformat Platform, Clayton, Vic 3800, Australia.
   [Ohara, Osamu] Kazusa DNA Res Inst Kisarazu, Chiba 2920818, Japan.
   [Grohmann, Marcus; Wiede, Florian; Dodd, Garron T.; Butt, Tariq; Kaur, Supreet; Goh, Pei K.] Monash Univ, Dept Biochem & Mol Biol, Clayton, Vic 3800, Australia.
   [Gurzov, Esteban N.] ULB, Route Lennik 808, B-1070 Brussels, Belgium.
   [Watt, Matthew J.] Univ Melbourne, Dept Physiol, Melbourne, Vic 3010, Australia.
C3 Monash University; Peter Maccallum Cancer Center; Monash University;
   Florey Institute of Neuroscience & Mental Health; Howard Florey
   Institute Affiliates; University of Veterinary Medicine Vienna; RIKEN;
   Florey Institute of Neuroscience & Mental Health; Howard Florey
   Institute Affiliates; Monash University; Monash University; Universite
   Libre de Bruxelles; University of Melbourne
RP Tiganis, T (corresponding author), Monash Univ, Monash Biomed Discovery Inst, Clayton, Vic 3800, Australia.; Tiganis, T (corresponding author), Peter MacCallum Canc Ctr, Melbourne, Vic 3000, Australia.
EM tony.tiganis@monash.edu
RI Watt, Matthew/B-2089-2014; Dodd, Garron/AAC-9171-2019; Tiganis,
   Tony/AAV-3495-2020; Brown, Wendy/H-7130-2014; Ohara, Osamu/G-5448-2015
OI McLean, Catriona/0000-0002-0302-5727; Butt, Tariq/0000-0001-7532-1747;
   Ohara, Osamu/0000-0002-3328-9571; Archer, Stuart/0000-0003-0450-1243;
   Dodd, Garron/0000-0002-7554-4876; Brown, Wendy/0000-0002-0137-2688;
   Muller, Mathias/0000-0002-7879-3552; Wiede, Florian/0000-0001-5145-7180;
   Gulati, Twishi/0000-0003-3841-8392; Gurzov, Esteban/0000-0003-4642-0273;
   Tiganis, Tony/0000-0002-8065-9942
FU NHMRC of Australia [1103037, 1047060, 107703, 1061278]; Cancer Council
   Victoria [1141137]; Association for International Cancer Research,
   United Kingdom [12-1172]; Austrian Science Fund, Vienna Austria [FWF SFB
   F6101, F6106]; National Health and Medical Research Council of Australia
   [1103037, 1061278] Funding Source: NHMRC
FX This work was supported by the NHMRC of Australia T.T. (1103037), T.T.
   and C.A.M. (1047060), and M.J.W. (107703 and 1061278), Cancer Council
   Victoria T.T. and C.A.M. (1141137), Association for International Cancer
   Research, United Kingdom to T.T. and C.A.M. (12-1172), and the Austrian
   Science Fund, Vienna Austria to M.M. (FWF SFB F6101 and F6106).
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NR 59
TC 273
Z9 302
U1 3
U2 63
PU CELL PRESS
PI CAMBRIDGE
PA 50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA
SN 0092-8674
EI 1097-4172
J9 CELL
JI Cell
PD NOV 15
PY 2018
VL 175
IS 5
BP 1289
EP +
DI 10.1016/j.cell.2018.09.053
PG 38
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA HA5PX
UT WOS:000450328800014
PM 30454647
OA Green Published
DA 2025-06-11
ER

PT J
AU Nemazanyy, I
   Montagnac, G
   Russell, RC
   Morzyglod, L
   Burnol, AF
   Guan, KL
   Pende, M
   Panasyuk, G
AF Nemazanyy, Ivan
   Montagnac, Guillaume
   Russell, Ryan C.
   Morzyglod, Lucille
   Burnol, Anne-Francoise
   Guan, Kun-Liang
   Pende, Mario
   Panasyuk, Ganna
TI Class III PI3K regulates organismal glucose homeostasis by providing
   negative feedback on hepatic insulin signalling
SO NATURE COMMUNICATIONS
LA English
DT Article
ID RECEPTOR-MEDIATED ENDOCYTOSIS; FORKHEAD TRANSCRIPTION FACTOR;
   PHOSPHATIDYLINOSITOL 3-KINASE; CELL-SURVIVAL; RAT-LIVER;
   LIPID-METABOLISM; NUTRIENT STRESS; CRE RECOMBINASE; FATTY LIVER; BECLIN
   1
AB Defective hepatic insulin receptor (IR) signalling is a pathogenic manifestation of metabolic disorders including obesity and diabetes. The endo/lysosomal trafficking system may coordinate insulin action and nutrient homeostasis by endocytosis of IR and the autophagic control of intracellular nutrient levels. Here we show that class III PI3K-a master regulator of endocytosis, endosomal sorting and autophagy-provides negative feedback on hepatic insulin signalling. The ultraviolet radiation resistance-associated gene protein (UVRAG)associated class III PI3K complex interacts with IR and is stimulated by insulin treatment. Acute and chronic depletion of hepatic Vps15, the regulatory subunit of class III PI3K, increases insulin sensitivity and Akt signalling, an effect that requires functional IR. This is reflected by FoxO1-dependent transcriptional defects and blunted gluconeogenesis in Vps15 mutant cells. On depletion of Vps15, the metabolic syndrome in genetic and diet-induced models of insulin resistance and diabetes is alleviated. Thus, feedback regulation of IR trafficking and function by class III PI3K may be a therapeutic target in metabolic conditions of insulin resistance.
C1 [Nemazanyy, Ivan; Pende, Mario; Panasyuk, Ganna] INEM, F-75993 Paris 14, France.
   [Nemazanyy, Ivan; Pende, Mario; Panasyuk, Ganna] INSERM, U1151, F-75993 Paris 14, France.
   [Nemazanyy, Ivan; Morzyglod, Lucille; Burnol, Anne-Francoise; Pende, Mario; Panasyuk, Ganna] Univ Paris 05, Sorbonne Paris Cite, F-75006 Paris, France.
   [Montagnac, Guillaume] Inst Gustave Roussy, INSERM, U1170, F-94805 Villejuif, France.
   [Russell, Ryan C.; Guan, Kun-Liang] Univ Calif San Diego, Dept Pharmacol, La Jolla, CA 92093 USA.
   [Russell, Ryan C.; Guan, Kun-Liang] Univ Calif San Diego, Moores Canc Ctr, La Jolla, CA 92093 USA.
   [Morzyglod, Lucille; Burnol, Anne-Francoise] Inst Cochin Genet Mol, INSERM, U1016, F-75014 Paris, France.
   [Morzyglod, Lucille; Burnol, Anne-Francoise] CNRS, UMR8104, F-75014 Paris, France.
C3 Institut National de la Sante et de la Recherche Medicale (Inserm);
   Universite Paris Cite; Universite Paris Saclay; UNICANCER; Gustave
   Roussy; Institut National de la Sante et de la Recherche Medicale
   (Inserm); University of California System; University of California San
   Diego; University of California System; University of California San
   Diego; Universite Paris Cite; Institut National de la Sante et de la
   Recherche Medicale (Inserm); Centre National de la Recherche
   Scientifique (CNRS); CNRS - National Institute for Biology (INSB);
   Universite Paris Cite
RP Pende, M (corresponding author), INEM, F-75993 Paris 14, France.
EM mario.pende@inserm.fr; ganna.panasyuk@inserm.fr
RI Pende, Mario/AFR-1348-2022; Guan, Kun-Liang/ADK-7088-2022; Burnol,
   Anne-Francoise/P-2181-2017; montagnac, guillaume/Y-3654-2018; Panasyuk,
   Ganna/A-4133-2018
OI Pende, Mario/0000-0002-7864-8937; Russell, Ryan/0000-0003-3364-8869;
   Panasyuk, Ganna/0000-0002-5591-848X
FU European Research Council; European 7th Framework MyoAge program;
   Fondation de la Recherche Medicale; Fondation Schlumberger pour
   l'Education et la Recherche; European Foundation for the Study of
   Diabetes; Institut National du Cancer (INCa); French Muscular Dystrophy
   Asscoiation (AFM); Agence nationale de la recherche
   [ANR-10-Wnt-Metaboliv]; Fondation pour la Recherche Medicale; National
   Institutes of Health, U.S.A. [GM51586]; Fondation Tourre; EFSD; INCa;
   EMBO; French Ministry of Research; ATIP-Avenir Plan Cancer Programme
FX We are grateful to the members of INSERM-U1151 for support, and to
   Patrice Codogno and Owen Sansom for helpful discussions and sharing
   reagents. We thank Sophie Berissi (Small animal histology and morphology
   platform) and Sylvie Fabrega (Viral vector and gene transfer platform)
   for excellent technical support. The mouse mutant line was established
   at the Mouse Clinical Institute (Institute Clinique de la Souris,
   MCI/ICS) in the Genetic Engineering and Model Validation Department.
   This work was supported by grants from the European Research Council,
   from the European 7th Framework MyoAge program, from Fondation de la
   Recherche Medicale), from Fondation Schlumberger pour l'Education et la
   Recherche, from European Foundation for the Study of Diabetes, from
   Institut National du Cancer (INCa), from French Muscular Dystrophy
   Asscoiation (AFM) to M.P.; from the Agence nationale de la recherche
   (ANR-10-Wnt-Metaboliv) and by the Fondation pour la Recherche Medicale
   (Labelisation Equipe) to A.-F.B.; from the National Institutes of
   Health, U.S.A. (GM51586) to K.L.G. G.P. was supported by Fondation
   Tourre, EFSD and INCa. I.N. was supported by EFSD, INCa and EMBO Short
   Term Fellowship. L.M. was supported by a PhD grant from the French
   Ministry of Research. G.M. was supported by the ATIP-Avenir Plan Cancer
   Programme.
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NR 70
TC 38
Z9 44
U1 0
U2 21
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 2041-1723
J9 NAT COMMUN
JI Nat. Commun.
PD SEP
PY 2015
VL 6
AR 8283
DI 10.1038/ncomms9283
PG 16
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA CT7UC
UT WOS:000363019000013
PM 26387534
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Ma, H
   Xu, CF
   Xu, L
   Yu, CH
   Mao, M
   Li, YM
AF Ma, Han
   Xu, Chengfu
   Xu, Lei
   Yu, Chaohui
   Mao, Min
   Li, Youming
TI Independent association of HbA1c and nonalcoholic fatty liver disease in
   an elderly Chinese population
SO BMC GASTROENTEROLOGY
LA English
DT Article
DE Fatty liver; Glycosylated hemoglobin; Elderly; Obesity
ID METABOLIC SYNDROME; GLYCOSYLATED HEMOGLOBIN; CARDIOVASCULAR-DISEASE;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; PATHOGENESIS; PREVALENCE;
   STEATOSIS; DIAGNOSIS; MEMBRANE
AB Background: To investigate the association between serum glycosylated hemoglobin (HbA1c) levels and nonalcoholic fatty liver disease (NAFLD) in an elderly Chinese population.
   Methods: A cross-sectional study was performed among the 949 retired elderly employees of Zhenhai Refining & Chemical Company Ltd., Ningbo, China.
   Results: A total of 257 (27.08%) subjects fulfilled the diagnostic criteria of NAFLD, and NAFLD patients had significantly higher serum HbA1c levels than controls (P <0.001). The prevalence of NAFLD was significantly higher in subjects with increased serum HbA1c level (HbA1c >= 6.5%) than in those with normal range of serum HbA1c level (51.71% vs. 25.20%; P <0.001), and the prevalence increased along with progressively higher serum HbA1c levels (P for trend <0.001). Stepwise logistic regression analysis showed that serum HbA1c level was significantly associated with the risk for NAFLD (odds ratio: 1.547, 95% confidence interval: 1.054 - 2.270; P =0.026).
   Conclusions: Our results suggest that serum HbA1c level is associated with NAFLD, and increased serum HbA1c level is an independent risk factor for NAFLD in elderly Chinese.
C1 [Ma, Han; Xu, Chengfu; Xu, Lei; Yu, Chaohui; Li, Youming] Zhejiang Univ, Sch Med, Affiliated Hosp 1, Dept Gastroenterol, Hangzhou 310003, Zhejiang, Peoples R China.
   [Xu, Lei] Ningbo 1 Hosp, Dept Gastroenterol, Ningbo, Zhejiang, Peoples R China.
   [Mao, Min] Zhenhai Lianhua Hosp, Dept Internal Med, Ningbo, Zhejiang, Peoples R China.
C3 Zhejiang University
RP Li, YM (corresponding author), Zhejiang Univ, Sch Med, Affiliated Hosp 1, Dept Gastroenterol, 79 Qingchun Rd, Hangzhou 310003, Zhejiang, Peoples R China.
EM xiaofu@zju.edu.cn
RI Xu, Chengfu/HTL-9950-2023; Mao, Min/IAQ-2666-2023
OI Xu, Chengfu/0000-0002-6172-1253; Ma, Han/0000-0001-9985-3035
FU National Key Basic Research Development Program [2012CB524905]; National
   Science and Technology Support Plan Project [2012BAI06B04]; National
   Natural Science Foundation of China [31070315, 81100278, 81170378];
   Zhejiang Provincial Natural Science Foundation of China [Y2110026];
   Science Foundation of Health Bureau of Zhejiang Province [2012RCA026]
FX This study was supported by National Key Basic Research Development
   Program (No. 2012CB524905), National Science and Technology Support Plan
   Project (No. 2012BAI06B04), National Natural Science Foundation of China
   (Nos. 31070315, 81100278, and 81170378), Zhejiang Provincial Natural
   Science Foundation of China (No. Y2110026), and Science Foundation of
   Health Bureau of Zhejiang Province (No. 2012RCA026). The funders had no
   role in study design, data collection and analysis, decision to publish,
   or preparation of the manuscript. The authors thank Drs. Tong Huang and
   Jingyi Yuan at Zhenhai Lianhua Hospital, Ningbo, China for their help in
   data collection.
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NR 34
TC 34
Z9 42
U1 0
U2 11
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-230X
J9 BMC GASTROENTEROL
JI BMC Gastroenterol.
PD JAN 7
PY 2013
VL 13
AR 3
DI 10.1186/1471-230X-13-3
PG 6
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 070OV
UT WOS:000313519800001
PM 23294935
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Mattei, J
   Tamez, M
   Ríos-Bedoya, CF
   Xiao, RS
   Tucker, KL
   Rodríguez-Orengo, JF
AF Mattei, Josiemer
   Tamez, Martha
   Rios-Bedoya, Carlos F.
   Xiao, Rui S.
   Tucker, Katherine L.
   Rodriguez-Orengo, Jose F.
TI Health conditions and lifestyle risk factors of adults living in Puerto
   Rico: a cross-sectional study
SO BMC PUBLIC HEALTH
LA English
DT Article
DE Puerto Rico; Health disparities; Chronic disease; Lifestyle risk
   factors; Population health
ID JUAN METROPOLITAN-AREA; METABOLIC SYNDROME; SAN-JUAN; CHRONIC DISEASES;
   SOCIAL SUPPORT; UNITED-STATES; PREVALENCE; CARE; BACKGROUNDS;
   DISPARITIES
AB Background: Puerto Rico is experiencing an economic and healthcare crisis, yet there are scarce recent and comprehensive reports on the population's health profile. We aimed to describe prevalent risk factors and health conditions of adults living in Puerto Rico and assess their interrelationship.
   Methods: Participants (n = 380) aged 30-75y recruited from a 2015 convenience sample in primary care clinics in the San Juan, Puerto Rico metropolitan area answered cross-sectional interviewer-administered questionnaires on sociodemographic characteristics, lifestyle behaviors, self-reported medically-diagnosed diseases, health services, and psychosocial factors. Anthropometric measures were obtained. Logistic regression models assessed factors associated with having >= 2 cardiometabolic conditions or >= 2 chronic diseases.
   Results: Most participants had completed = college education (57%), had household income <$10,000/y (60%), received government-assisted food benefits (51%), and had health insurance (93%). Nearly 20% reported smoking, 27% alcohol use, 74% light/sedentary physical activity, 51% sleeping difficulties, and 36% self-rated fair/poor diet. Social support was moderate, and 53% screened positive for depressive symptomatology. Abdominal obesity was observed in 33% of men and 76% of women (p < 0.0001). Self-reported medically-diagnosed conditions included hypertension (39%), anxiety (30%), obesity (28%), arthritis (26%), hypercholesterolemia (24%), depression (22%), respiratory problems (21%), and diabetes (21%). Higher odds of having >= 2 cardiometabolic conditions (37%) was observed among participants aged >= 50y, with sedentary physical activity, and self-rated fair/poor diet. Odds of having = 2 chronic diseases (62%) were higher among >= 50y, sleeping difficulties, > 2 h/day television, and self-rated fair/poor diet. Participants obtained (79%) and trusted (92%) health information from physicians. While most participants with a cardiometabolic condition reported receiving medical recommendations on diet (> 73%) and physical activity (> 67%), fewer followed them (< 67% and < 53%, respectively), yet most adhered to medication treatments (> 73%). Participants following medical recommendations were more likely to report healthy vs. poor behaviors (90% vs. 75%, self-rated diet); (73% vs. 56%, physical activity).
   Conclusions: Adults living in Puerto Rico have multiple lifestyles risk factors and high prevalence of chronic diseases, namely cardiometabolic and psychological conditions. Comprehensive epidemiological studies are needed to identify contributors to chronic disease, including lifestyle behaviors. Concerted multi-level public health and clinical programs should be prioritized to help this population improve their health.
C1 [Mattei, Josiemer; Tamez, Martha; Xiao, Rui S.] Harvard TH Chan Sch Publ Hlth, Dept Nutr, 665 Huntington Ave,Bldg 2, Boston, MA 02115 USA.
   [Rios-Bedoya, Carlos F.] Hurley Med Ctr, Dept Internal Med, Flint, MI USA.
   [Rios-Bedoya, Carlos F.; Rodriguez-Orengo, Jose F.] FDI Clin Res, San Juan, PR USA.
   [Tucker, Katherine L.] Univ Massachusetts, Dept Biochem & Nutr Sci, Lowell, MA USA.
   [Rodriguez-Orengo, Jose F.] Univ Puerto Rico, Dept Biochem, Sch Med, Med Sci Campus, San Juan, PR USA.
C3 Harvard University; Harvard T.H. Chan School of Public Health;
   University of Massachusetts System; University of Massachusetts Lowell;
   University of Puerto Rico; University of Puerto Rico Medical Sciences
   Campus
RP Mattei, J (corresponding author), Harvard TH Chan Sch Publ Hlth, Dept Nutr, 665 Huntington Ave,Bldg 2, Boston, MA 02115 USA.
EM jmattei@hsph.harvard.edu
RI Tucker, Katherine/A-4545-2010; Mattei, Josiemer/H-1800-2016
OI Tucker, Katherine/0000-0001-7640-662X; Tamez,
   Martha/0000-0003-3164-1647; Mattei, Josiemer/0000-0001-5424-8245
FU Northarvest Bean Growers Association; FDI Clinical Research; National
   Heart, Lung, and Blood Institute at the National Institutes of Health
   [K01-HL120951]
FX This work was supported by private anonymous donations to Harvard TH
   Chan School of Public Health; a Dry Bean Health Research Program
   Incentive Award from the Northarvest Bean Growers Association;
   institutional funds from FDI Clinical Research; and the National Heart,
   Lung, and Blood Institute at the National Institutes of Health (grant
   number K01-HL120951) to JM.
CR [Anonymous], 2008, REPORT WHO EXPERT CO
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NR 43
TC 40
Z9 50
U1 0
U2 23
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1471-2458
J9 BMC PUBLIC HEALTH
JI BMC Public Health
PD APR 12
PY 2018
VL 18
AR 491
DI 10.1186/s12889-018-5359-z
PG 12
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA GC5UV
UT WOS:000429856500001
PM 29650018
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Zhao, SS
   Guo, Y
   Yin, XZ
AF Zhao, Shuangshuang
   Guo, Yan
   Yin, Xunzhe
TI Autophagy, Ferroptosis, Apoptosis and Pyroptosis in Metabolic
   Dysfunction-Associated Steatotic Liver Disease
SO FRONTIERS IN BIOSCIENCE-LANDMARK
LA English
DT Review
DE autophagy; ferroptosis; apoptosis; pyroptosis; metabolic
   dysfunction-associated steatotic liver disease
ID NONALCOHOLIC STEATOHEPATITIS; CELL-DEATH; MOLECULAR-MECHANISMS;
   LIPID-METABOLISM; FIBROSIS; NASH; DEGRADATION; GLUTATHIONE; NAFLD; MICE
AB Metabolic dysfunction-associated steatotic liver disease (MASLD) has a global prevalence of 25% and isa leading cause of cirrhosis and hepatocellular carcinoma. The prevalence of MASLD has been increasing, mirroring the global increase in diabetes and metabolic syndrome. MASLD is a chronic and progressive condition characterized by inflammation, oxidative stress, insulin resistance, and disruptions in lipid metabolism. Programmed cell death (PCD) plays a pivotal role in determining the pathological aspects of MASLD, including liver inflammation, fibrosis, and even the potential for malignant transformation. PCD is a dominant process that is fundamental for eukaryotic growth and serves as a regulatory factor in MASLD. PCD encompasses various pathways, including autophagy, ferroptosis, apoptosis, and pyroptosis. These PCD pathways can be activated at different stages of MASLD. The key effector molecules involved in these processes are central focal points in the development of therapeutic interventions for MASLD. Here, we comprehensively review the idea that targeted the modulation of the PCD pathway may be an effective approach for the prevention and/or treatment of MASLD.
C1 [Zhao, Shuangshuang; Guo, Yan] Changchun Univ Chinese Med, Sch Clin Med, Changchun 130117, Jilin, Peoples R China.
   [Yin, Xunzhe] Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Electroanalyt Chem, Changchun 130022, Jilin, Peoples R China.
C3 Changchun University of Chinese Medicine; Chinese Academy of Sciences;
   Changchun Institute of Applied Chemistry, CAS
RP Guo, Y (corresponding author), Changchun Univ Chinese Med, Sch Clin Med, Changchun 130117, Jilin, Peoples R China.; Yin, XZ (corresponding author), Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Electroanalyt Chem, Changchun 130022, Jilin, Peoples R China.
EM ccguoyan@163.com; xzyin@ciac.ac.cn
FU Science and Technol-ogy Development Plan of Jilin Province
   [20210204029YY, YDZJ202201ZYTS151]
FX Funding This work was supported by the Science and Technol-ogy
   Development Plan of Jilin Province (20210204029YY and YDZJ202201ZYTS151)
   .
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NR 125
TC 6
Z9 7
U1 6
U2 16
PU IMR PRESS
PI ROBINSON
PA 112 ROBINSON RD, ROBINSON, SINGAPORE
SN 2768-6701
EI 2768-6698
J9 FRONT BIOSCI-LANDMRK
JI Front. Biosci.
PD JAN
PY 2024
VL 29
IS 1
AR 30
DI 10.31083/j.fbl2901030
PG 15
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA GW7C1
UT WOS:001155765700028
PM 38287834
OA gold
DA 2025-06-11
ER

PT J
AU Shunkina, D
   Dakhnevich, A
   Shunkin, E
   Khaziakhmatova, O
   Shupletsova, V
   Vulf, M
   Komar, A
   Kirienkova, E
   Litvinova, L
AF Shunkina, Daria
   Dakhnevich, Anastasia
   Shunkin, Egor
   Khaziakhmatova, Olga
   Shupletsova, Valeria
   Vulf, Maria
   Komar, Alexandra
   Kirienkova, Elena
   Litvinova, Larisa
TI gp130 Activates Mitochondrial Dynamics for Hepatocyte Survival in a
   Model of Steatohepatitis
SO BIOMEDICINES
LA English
DT Article
DE metabolic syndrome; non-alcoholic fatty liver disease (NAFLD); IL-6;
   gp130; mitochondria; oxidative stress; inflammation; metabolism
ID SUPEROXIDE-DISMUTASE; LIVER; INTERLEUKIN-6; DYSFUNCTION; PATHWAY; IL-6
AB Obesity is the main cause of metabolic complications. Fatty liver infiltration is a companion of obesity. NAFLD is associated with impaired energy metabolism with an excess of nutrients. Mitochondrial dynamics are important for the regulation of energy balance, which regulates mitochondrial function, apoptosis, and mitophagy. The aim of this study was to investigate the effect of gp130 on the components of mitochondrial dynamics in a cellular model of steatohepatitis. Addition of IL-6/gp130 contributed to an increase in the percentage of live cells and a decrease in the percentage of dead and apoptotic cells. Addition of IL-6/gp130 increased the expression of NF-kB1 gene and mitochondrial dynamics markers (MFN2 and TFAM) in HepG2 with tBHP/Oleic. Addition of IL-6 or gp130 reduced the expression of cytoprotector genes (HSF1 and HSP70) in HepG2 cell cultures with tBHP/Oleic. Increased mitochondrial dynamics gene activity protected against HepG2 cell death in the steatohepatitis model. Trans-signaling resulted in increased TFAM and MAPLC3B, and decreased DNM1L gene expression in HepG2 with tBHP/Oleic.
C1 [Shunkina, Daria; Dakhnevich, Anastasia; Shunkin, Egor; Khaziakhmatova, Olga; Shupletsova, Valeria; Vulf, Maria; Komar, Alexandra; Kirienkova, Elena; Litvinova, Larisa] Immanuel Kant Balt Fed Univ, Ctr Immunol & Cellular Biotechnol, Kaliningrad 236041, Russia.
C3 Immanuel Kant Baltic Federal University
RP Shunkina, D (corresponding author), Immanuel Kant Balt Fed Univ, Ctr Immunol & Cellular Biotechnol, Kaliningrad 236041, Russia.
EM dariask@list.ru
RI Shunkina, Daria/K-7525-2019; Dakhnevich, Anastasiia/HOH-8745-2023;
   Shupletsova, Valeria/D-3979-2018; Shunkin, Egor/H-1911-2019; Kirienkova,
   Elena/B-2164-2014; Khaziakhmatova, Olga/F-7767-2017; Litvinova,
   Larisa/A-9672-2014; Vulf, Maria/E-4926-2017
OI Shunkina (Skuratovskaia), Daria/0000-0002-8679-1135; Litvinova,
   Larisa/0000-0001-5231-6910; Vulf, Maria/0000-0002-4989-045X; ,
   Dakhnevich Anastasia/0009-0008-6063-4079
FU State Assignment Grant [FZWM-2020-0010];  [MK-925.2022.1.4]
FX This research was funded by Presidential Grant grant number
   MK-925.2022.1.4 and The APC was funded by State Assignment Grant grant
   number FZWM-2020-0010.
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NR 49
TC 2
Z9 2
U1 1
U2 6
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2227-9059
J9 BIOMEDICINES
JI Biomedicines
PD FEB
PY 2023
VL 11
IS 2
AR 396
DI 10.3390/biomedicines11020396
PG 17
WC Biochemistry & Molecular Biology; Medicine, Research & Experimental;
   Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Research & Experimental Medicine;
   Pharmacology & Pharmacy
GA 9H5MZ
UT WOS:000938878200001
PM 36830933
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Bukhari, SNA
   Asif, H
   Alamgeer
   Asim, MH
   Irfan, HM
   Ejaz, H
   Elsherif, MA
   Junaid, K
AF Bukhari, Syed Nasir Abbas
   Asif, Hira
   Alamgeer
   Asim, Mulazim Hussain
   Muhammad Irfan, Hafiz
   Ejaz, Hasan
   Elsherif, Mervat A.
   Junaid, Kashaf
TI Protective Effect of Butanolic Fraction of Delphinium brunonianum
   on Fructose-Mediated Metabolic Alterations in Rats
SO METABOLITES
LA English
DT Article
DE metabolic syndrome; oxidative stress; sympathetic over-activity; insulin
   resistance; LC-MS analysis
ID P-COUMARIC ACID; INSULIN-RESISTANCE; DIURETIC ACTIVITY; DIETARY
   FRUCTOSE; ASCORBIC-ACID; LEAF EXTRACT; ANTIOXIDANT; GLUCOSE;
   HYPERURICEMIA; PREVENTS
AB The present study was conducted with an intent to evaluate the protective effect of butanolic fraction of Delphinium brunonianum on fructose mediated metabolic abnormalities in rats. Rats in all groups except control group were fed on 10% fructose for 6 weeks; however, rats in the treated group also received butanolic fraction for the last 3 weeks, along with the fructose. Moreover, phytoconstituents present in butanolic fraction were analyzed using LC-MS. All doses of butanolic fraction profoundly reduce the fructose-induced blood pressure, sympathetic over-activity, and weight gain. Furthermore, butanolic fraction prominently reduces the glucose intolerance and hyperinsulinemia in fructose-fed rats. On treatment with butanolic fraction, oxidative enzymes and the functionality of the aorta was also restored. Phytochemical analysis revealed the presence of several active constituents including bergenin, scopolin, rutinoside, kaempferol, coumaric acid, apigenin, and gingerol. In conclusion, butanolic fraction of Delphinium brunonianum has the potential to prevent and recover the fructose-induced metabolic perturbations.
C1 [Bukhari, Syed Nasir Abbas] Jouf Univ, Dept Pharmaceut Chem, Coll Pharm, Sakaka 72388, Saudi Arabia.
   [Asif, Hira] Lahore Pharm Coll, Lahore Med & Dent Coll, Lahore 54850, Pakistan.
   [Asif, Hira; Alamgeer; Asim, Mulazim Hussain; Muhammad Irfan, Hafiz] Univ Sargodha, Coll Pharm, Sargodha 40100, Pakistan.
   [Alamgeer] Univ Punjab, Coll Pharm, Lahore 05422, Pakistan.
   [Ejaz, Hasan; Junaid, Kashaf] Jouf Univ, Dept Clin Lab Sci, Coll Appl Med Sci, Sakaka 72388, Saudi Arabia.
   [Elsherif, Mervat A.] Jouf Univ, Coll Sci, Dept Chem, Sakaka 72388, Saudi Arabia.
C3 Al Jouf University; University of Sargodha; University of Punjab; Al
   Jouf University; Al Jouf University
RP Asif, H (corresponding author), Lahore Pharm Coll, Lahore Med & Dent Coll, Lahore 54850, Pakistan.; Asif, H; Alamgeer (corresponding author), Univ Sargodha, Coll Pharm, Sargodha 40100, Pakistan.; Alamgeer (corresponding author), Univ Punjab, Coll Pharm, Lahore 05422, Pakistan.
EM sbukhari@ju.edu.sa; hira.asif@lmdc.edu.pk; alamgeer.pharmacy@pu.edu.pk;
   asimawan786pk@gmail.com; irfan_pharmacist06@yahoo.com;
   hetariq@ju.edu.sa; maelsherif@ju.edu.sa; kjunaid@ju.edu.sa
RI Junaid, Kashaf/AAU-3693-2020; Alamgeer/K-8284-2019; Irfan,
   Muhammad/K-8432-2019; Asif, Dr. Hira/J-7340-2016; Hussain Asim, Dr.
   Mulazim/AAA-4051-2020; Bukhari, Syed Nasir Abbas/R-3825-2017; Ejaz,
   Hasan/V-8762-2018
OI Hussain Asim, Dr. Mulazim/0000-0003-1910-9615; Junaid,
   Kashaf/0000-0001-5328-4105; Bukhari, Syed Nasir
   Abbas/0000-0001-8125-7972; Ejaz, Hasan/0000-0002-6185-2042; Asif, Dr.
   Hira/0000-0002-3027-4518; -, Dr Alamgeer/0000-0003-4775-7337
FU Deputyship for Research and Innovation, Ministry of Education, in Saudi
   Arabia [375213500]
FX The authors' work was supported through grant number "375213500" from
   the Deputyship for Research and Innovation, Ministry of Education, in
   Saudi Arabia.
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NR 50
TC 3
Z9 3
U1 0
U2 5
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2218-1989
J9 METABOLITES
JI Metabolites
PD JUN
PY 2022
VL 12
IS 6
AR 481
DI 10.3390/metabo12060481
PG 15
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 2L0DF
UT WOS:000816694600001
PM 35736413
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Goldberg, IJ
   Reue, K
   Abumrad, NA
   Bickel, PE
   Cohen, S
   Fisher, EA
   Galis, ZS
   Granneman, JG
   Lewandowski, ED
   Murphy, R
   Olive, M
   Schaffer, JE
   Schwartz-Longacre, L
   Shulman, GI
   Walther, TC
   Chen, J
AF Goldberg, Ira J.
   Reue, Karen
   Abumrad, Nada A.
   Bickel, Perry E.
   Cohen, Sarah
   Fisher, Edward A.
   Galis, Zorina S.
   Granneman, James G.
   Lewandowski, E. Douglas
   Murphy, Robert
   Olive, Michelle
   Schaffer, Jean E.
   Schwartz-Longacre, Lisa
   Shulman, Gerald I.
   Walther, Tobias C.
   Chen, Jue
TI Deciphering the Role of Lipid Droplets in Cardiovascular Disease: A
   Report From the 2017 National Heart, Lung, and Blood Institute Workshop
SO CIRCULATION
LA English
DT Article
DE atherosclerosis; heart failure; metabolic syndrome; obesity;
   triglycerides
ID SMOOTH-MUSCLE-CELLS; FATTY-ACID UPTAKE; INSULIN-RESISTANCE; PERILIPIN 5;
   PPAR-ALPHA; CHOLESTEROL ACCUMULATION; CARDIAC STEATOSIS; OXIDATIVE
   STRESS; PHYSICAL STATE; CD36 PROTEIN
AB Lipid droplets (LDs) are distinct and dynamic organelles that affect the health of cells and organs. Much progress has been made in understanding how these structures are formed, how they interact with other cellular organelles, how they are used for storage of triacylglycerol in adipose tissue, and how they regulate lipolysis. Our understanding of the biology of LDs in the heart and vascular tissue is relatively primitive in comparison with LDs in adipose tissue and liver. The National Heart, Lung, and Blood Institute convened a working group to discuss how LDs affect cardiovascular diseases. The goal of the working group was to examine the current state of knowledge on the cell biology of LDs, including current methods to study them in cells and organs and reflect on how LDs influence the development and progression of cardiovascular diseases. This review summarizes the working group discussion and recommendations on research areas ripe for future investigation that will likely improve our understanding of atherosclerosis and heart function.
C1 [Goldberg, Ira J.; Fisher, Edward A.] NYU, New York, NY USA.
   [Reue, Karen] Univ Calif Los Angeles, Los Angeles, CA USA.
   [Abumrad, Nada A.; Schaffer, Jean E.] Washington Univ, St Louis, MO USA.
   [Bickel, Perry E.] Univ Texas Southwestern Med Ctr Dallas, Dallas, TX 75390 USA.
   [Cohen, Sarah] Univ N Carolina, Chapel Hill, NC 27515 USA.
   [Galis, Zorina S.; Olive, Michelle; Schwartz-Longacre, Lisa; Chen, Jue] NHLBI, NIH, Bldg 10, Bethesda, MD 20892 USA.
   [Granneman, James G.] Wayne State Univ, Detroit, MI USA.
   [Lewandowski, E. Douglas] Ohio State Univ, Wexner Med Ctr, Columbus, OH 43210 USA.
   [Murphy, Robert] Univ Colorado, Denver, CO 80202 USA.
   [Shulman, Gerald I.] Yale Univ, Howard Hughes Med Inst, New Haven, CT 06511 USA.
   [Walther, Tobias C.] Harvard Univ, Howard Hughes Med Inst, Boston, MA 02115 USA.
C3 New York University; University of California System; University of
   California Los Angeles; Washington University (WUSTL); University of
   Texas System; University of Texas Southwestern Medical Center Dallas;
   University of North Carolina; University of North Carolina Chapel Hill;
   National Institutes of Health (NIH) - USA; NIH National Heart Lung &
   Blood Institute (NHLBI); Wayne State University; University System of
   Ohio; Ohio State University; University of Colorado System; University
   of Colorado Denver; Yale University; Howard Hughes Medical Institute;
   Howard Hughes Medical Institute; Harvard University
RP Chen, J (corresponding author), NHLBI, Div Cardiovasc Sci, Rm 8160,6701 Rockledge Dr, Bethesda, MD 20892 USA.
EM jue.chen@nih.gov
RI Shulman, Gerald/P-7176-2019; Fisher, Edward/ABE-7469-2020; Olivé,
   Montse/AAI-6150-2021; Bickel, Perry/Q-9185-2019; Ribeiro de Andrade
   Ramos, Bruna/P-6448-2015
OI Walther, Tobias/0000-0003-1442-1327; Shulman,
   Gerald/0000-0003-1529-5668; Galis, Zorina S./0000-0001-6686-4766
FU National Heart, Lung, and Blood Institute (NHLBI), National Institutes
   of Health (NIH); NIH Intramural Program, National Institute of Child
   Health and Human Development; Howard Hughes Medical Institute; G. Harold
   and Leila Y. Mathers Foundation;  [R01 DK033301];  [R01 DK060022];  [R01
   DK111175];  [R01 HL127930];  [R01 HL084312];  [PO1 HL092969];  [R01
   HL129433];  [R01 DK 076629];  [R01 DK105963];  [R01 HL073029];  [R01
   HL045095];  [R01 HL127649];  [R01 HL132525];  [R01 HL049244];  [R01
   HL113057];  [P01 HL028481];  [P01 HL090553];  [R01 DK064989];  [R01
   DK108357];  [R01 DK113984];  [R01 DK40936];  [P30 DK045735];  [R01
   GM097194]; National Institute of Diabetes and Digestive and Kidney
   Diseases [P30DK020572] Funding Source: NIH RePORTER
FX This Workshop was supported by the National Heart, Lung, and Blood
   Institute (NHLBI), National Institutes of Health (NIH). Relevant grant
   supports of authors are as follows: Dr Abumrad: R01 DK033301, R01
   DK060022, and R01 DK111175; Dr Cohen: NIH Intramural Program, National
   Institute of Child Health and Human Development; Dr Fisher: R01
   HL127930, R01 HL084312, PO1 HL092969, and R01 HL129433; Dr Granneman:
   R01 DK 076629 and R01 DK105963; Dr Goldberg: R01 HL073029, R01 HL045095,
   PO1 HL092969, and R01 HL127649; Dr Lewandowski: R01 HL132525, R01
   HL049244, and R01 HL113057; Dr Reue: P01 HL028481 and P01 HL090553; Dr
   Schaffer: R01 DK064989 and R01 DK108357; Dr Shulman: R01 DK113984, R01
   DK40936, P30 DK045735, and the Howard Hughes Medical Institute; Dr
   Walther: R01 GM097194, the G. Harold and Leila Y. Mathers Foundation,
   and the Howard Hughes Medical Institute.
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NR 101
TC 101
Z9 110
U1 0
U2 25
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0009-7322
EI 1524-4539
J9 CIRCULATION
JI Circulation
PD JUL 17
PY 2018
VL 138
IS 3
BP 305
EP 315
DI 10.1161/CIRCULATIONAHA.118.033704
PG 11
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA GN1IK
UT WOS:000438742400010
PM 30012703
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Kahal, H
   Kyrou, I
   Tahrani, AA
   Randeva, HS
AF Kahal, Hassan
   Kyrou, Ioannis
   Tahrani, Abd A.
   Randeva, Harpal S.
TI Obstructive sleep apnoea and polycystic ovary syndrome: A comprehensive
   review of clinical interactions and underlying pathophysiology
SO CLINICAL ENDOCRINOLOGY
LA English
DT Review
DE hyperandrogenism; insulin resistance; obesity; obstructive sleep apnoea;
   polycystic ovary syndrome
ID SYMPATHETIC-NERVOUS-SYSTEM; POSITIVE AIRWAY PRESSURE;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; ENDOTHELIAL FUNCTION;
   LUTEINIZING-HORMONE; SYNDROME PCOS; OBESE WOMEN; ACTIVATION; IMPACT
AB Polycystic ovary syndrome (PCOS) is the most prevalent endocrine disorder in women of reproductive age. PCOS is associated with multiple comorbidities including, obesity, insulin resistance and type 2 diabetes, as well as mood disorders and impaired quality of life (QoL). Obstructive sleep apnoea (OSA) is also a common medical condition that is often undiagnosed, particularly in women. OSA is associated with a similar spectrum of comorbidities to that observed in PCOS, including manifestations of the metabolic syndrome and impaired QoL, whilst obesity frequently constitutes a common denominator in the pathophysiology of both OSA and PCOS. Hence, it is not surprising that OSA and PCOS may coexist in women of reproductive age, and the current clinical guidelines on the management of PCOS recommend screening for OSA symptoms in overweight/obese women with PCOS. In this review, we examine the relationship between OSA and PCOS and explore the potential underlying mechanisms that link these two conditions.
C1 [Kahal, Hassan; Kyrou, Ioannis; Randeva, Harpal S.] Univ Warwick, Div Translat & Expt Med, Warwick Med Sch, Coventry, W Midlands, England.
   [Kahal, Hassan; Kyrou, Ioannis; Randeva, Harpal S.] Univ Hosp Coventry & Warwickshire NHS Trust, WISDEM, Coventry, W Midlands, England.
   [Kyrou, Ioannis; Randeva, Harpal S.] Aston Univ, Aston Med Res Inst, Aston Med Sch, Birmingham, W Midlands, England.
   [Tahrani, Abd A.] Univ Birmingham, Inst Metab & Syst Res, Coll Med & Dent Sci, Birmingham, W Midlands, England.
   [Tahrani, Abd A.] Birmingham Hlth Partners, CEDAM, Birmingham, W Midlands, England.
   [Tahrani, Abd A.] Birmingham Heartlands Hosp, Dept Endocrinol & Diabet, Birmingham, W Midlands, England.
C3 University of Warwick; University of Warwick; Aston University;
   University of Birmingham; University of Birmingham; Heart of England NHS
   Foundation Trust; Heartlands Hospital
RP Randeva, HS (corresponding author), Univ Hosp Coventry & Warwickshire NHS Trust, WISDEM, Coventry, W Midlands, England.
EM Harpal.Randeva@warwick.ac.uk
RI Tahrani, Abd/C-6939-2014
OI Tahrani, Abd/0000-0001-9037-1937
FU National Institute for Health Research; NIHR
FX The authors declare that there is no conflict of interest that could be
   perceived as prejudicing the impartiality of the paper reported. No
   funding was received for doing this work. Dr Abd Tahrani is a Clinician
   Scientist supported by the National Institute for Health Research. The
   views expressed in this publication are those of the author(s) and not
   necessarily those of the NHS, the National Institute for Health Research
   or the Department of Health. NIHR Clinical Lectureship supported Dr.
   Hassan Kahal. All authors reviewed and edited the manuscript and
   approved the final version of the manuscript.
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NR 58
TC 44
Z9 48
U1 1
U2 20
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0300-0664
EI 1365-2265
J9 CLIN ENDOCRINOL
JI Clin. Endocrinol.
PD OCT
PY 2017
VL 87
IS 4
BP 313
EP 319
DI 10.1111/cen.13392
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA FF8NI
UT WOS:000409274700001
PM 28640938
OA Green Accepted, Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Buzzetti, E
   Pinzani, M
   Tsochatzis, EA
AF Buzzetti, Elena
   Pinzani, Massimo
   Tsochatzis, Emmanuel A.
TI The multiple-hit pathogenesis of non-alcoholic fatty liver disease
   (NAFLD)
SO METABOLISM-CLINICAL AND EXPERIMENTAL
LA English
DT Article
DE Insulin resistance; Lipotoxicity; Gut microbiome; Metabolic syndrome;
   PNPLA3
ID ENDOPLASMIC-RETICULUM STRESS; NECROSIS-FACTOR-ALPHA; DE-NOVO
   LIPOGENESIS; IMPROVES HEPATIC STEATOSIS; 3 GENE PNPLA3; NF-KAPPA-B;
   INSULIN-RESISTANCE; ADIPOSE-TISSUE; MITOCHONDRIAL DYSFUNCTION;
   INTESTINAL PERMEABILITY
AB Nonalcoholic fatty liver disease (NAFLD) is increasingly prevalent and represents a growing challenge in terms of prevention and treatment. Despite its high prevalence, only a small minority of affected patients develops inflammation and subsequently fibrosis and chronic liver disease, while most of them only exhibit simple steatosis. In this context, the full understanding of the mechanisms underlying the development of NAFLD and nonalcoholic steatohepatitis (NASH) is of extreme importance; despite advances in this field, knowledge on the pathogenesis of NAFLD is still incomplete. The 'two-hit' hypothesis is now obsolete, as it is inadequate to explain the several molecular and metabolic changes that take place in NAFLD. The "multiple hit" hypothesis considers multiple insults acting together on genetically predisposed subjects to induce NAFLD and provides a more accurate explanation of NAFLD pathogenesis. Such hits include insulin resistance, hormones secreted from the adipose tissue, nutritional factors, gut microbiota and genetic and epigenetic factors. In this article, we review the factors that form this hypothesis. (C) 2016 Elsevier Inc. All rights reserved.
C1 [Tsochatzis, Emmanuel A.] Royal Free Hosp, UCL Inst Liver & Digest Hlth, London, England.
   Royal Free Hosp, Sheila Sherlock Liver Unit, London, England.
   [Tsochatzis, Emmanuel A.] UCL, London, England.
C3 University of London; University College London; Royal Free London NHS
   Foundation Trust; UCL Medical School; University of London; University
   College London; Royal Free London NHS Foundation Trust; UCL Medical
   School; University of London; University College London
RP Tsochatzis, EA (corresponding author), Royal Free Hosp, UCL Inst Liver & Digest Hlth, London, England.; Tsochatzis, EA (corresponding author), UCL, London, England.
EM e.tsochatzis@ucl.ac.uk
RI Buzzetti, Elena/AAC-1975-2019; Tsochatzis, Emmanuel/A-1651-2012
OI Tsochatzis, Emmanuel/0000-0001-5069-2461; Buzzetti,
   Elena/0000-0002-4462-7935
FU AIGO (Associazione Italiana Gastroenterologi Ospedalieri); MIMI
   (Montecatini Interactive Medicine International)
FX Dr. Buzzetti was supported by an educational grant from AIGO
   (Associazione Italiana Gastroenterologi Ospedalieri) and MIMI
   (Montecatini Interactive Medicine International).
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NR 147
TC 2162
Z9 2385
U1 43
U2 719
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0026-0495
EI 1532-8600
J9 METABOLISM
JI Metab.-Clin. Exp.
PD AUG
PY 2016
VL 65
IS 8
BP 1038
EP 1048
DI 10.1016/j.metabol.2015.12.012
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA DR4RH
UT WOS:000379889400004
PM 26823198
OA Green Submitted
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Korkmaz, L
   Bastug, O
   Kurtoglu, S
AF Korkmaz, Levent
   Bastug, Osman
   Kurtoglu, Selim
TI Maternal Obesity and its Short- and Long-Term Maternal and Infantile
   Effects
SO JOURNAL OF CLINICAL RESEARCH IN PEDIATRIC ENDOCRINOLOGY
LA English
DT Article
DE Maternal obesity; fetal; neonatal; short; and long-term effects
ID BODY-MASS INDEX; GESTATIONAL WEIGHT-GAIN; METABOLIC SYNDROME;
   PROTEIN-TURNOVER; OXIDATIVE STRESS; RISK-FACTOR; PREGNANCY; WOMEN;
   OVERWEIGHT; AGE
AB Obesity, in childhood or in adulthood, remains to be a global health problem. The worldwide prevalence of obesity has increased in the last few decades, and consequently, the women of our time suffer more gestational problems than women in the past. The prevalence of obesity is greater in older women than in younger ones and in women with low educational level than in their counterparts with a higher level of education. Maternal obesity during pregnancy may increase congenital malformations and neonatal morbidity and mortality. Maternal obesity is associated with a decreased intention to breastfeed, decreased initiation of breastfeeding, and decreased duration of breastfeeding. We discuss the current epidemiological evidence for the association of maternal obesity with congenital structural neural tube and cardiac defects, fetal macrosomia that predisposes infants to birth injuries and to problems with physiological and metabolic transition, as well as potential for long-term complications secondary to prenatal and neonatal programming effects compounded by a reduction in sustained breastfeeding.
C1 [Korkmaz, Levent; Bastug, Osman] Erciyes Univ, Fac Med, Dept Pediat, Div Neonatol, Kayseri, Turkey.
   [Kurtoglu, Selim] Erciyes Univ, Fac Med, Dept Pediat, Div Endocrinol, Kayseri, Turkey.
C3 Erciyes University; Erciyes University
RP Korkmaz, L (corresponding author), Erciyes Univ, Fac Med, Dept Pediat, Div Neonatol, Kayseri, Turkey.
EM drleventkorkmaz@yahoo.com
OI Kurtoglu, Selim/0000-0002-5256-0128; Bastug, Osman/0000-0002-5753-0075
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NR 96
TC 14
Z9 18
U1 1
U2 11
PU GALENOS PUBL HOUSE
PI ISTANBUL
PA Kacamak Sokak 21/1, ISTANBUL, Findikzade, TURKIYE
SN 1308-5727
EI 1308-5735
J9 J CLIN RES PEDIATR E
JI J. Clin Res. Pediatr. Endocrinol.
PD JUN
PY 2016
VL 8
IS 2
BP 114
EP 124
DI 10.4274/jcrpe.2127
PG 11
WC Endocrinology & Metabolism; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Pediatrics
GA DP0HF
UT WOS:000378169400001
PM 26758575
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Sunbul, M
   Agirbasli, M
AF Sunbul, Murat
   Agirbasli, Mehmet
TI Psoriasis and Atherosclerosis: Is There a Need For Novel Biomarkers
   Assessing Cardiovascular Risk?
SO CURRENT PHARMACEUTICAL DESIGN
LA English
DT Article
DE Cardiovascular risk; psoriasis; psoriatic arthritis; inflammation;
   biomarker; atherosclerosis
ID PLASMINOGEN-ACTIVATOR INHIBITOR-1; NECROSIS-FACTOR-ALPHA;
   CORONARY-ARTERY-DISEASE; RHEUMATOID-ARTHRITIS; MYOCARDIAL-INFARCTION;
   METABOLIC SYNDROME; SUBCLINICAL ATHEROSCLEROSIS; HIGH PREVALENCE;
   DOUBLE-BLIND; MORTALITY
AB Epidemiological studies indicate increased mortality rates in cohorts of patients with psoriatic arthritis (PsA). Psoriasis is associated with an enhanced cardiovascular risk. The excess mortality in psoriasis and PsA is predominantly due to coronary artery disease. The aim of this review is to overview the biomarkers and/or mediators of increased cardiovascular risk in patients with psoriasis and PsA. We searched through Medline/PubMed to retrieve sources on cardiovascular disease (CVD), related risk factors and inflammatory markers in psoriasis and PsA. We analyzed the relationship between psoriasis and novel vascular biomarkers with potential use for preventive studies. Studies underline the importance of considering psoriatic patients as a high-risk population in terms of CVD. Novel biomarkers of inflammation, thrombosis, oxidative stress and atherosclerosis can provide risk stratification and strategies for early detection and treatment of CVD in patients with psoriasis. A better understanding of the association between psoriasis and vascular risk can help the clinician to manage the increased morbidity and mortality related to CVD.
C1 [Sunbul, Murat; Agirbasli, Mehmet] Marmara Univ, Sch Med, Dept Cardiol, Istanbul, Turkey.
C3 Marmara University
RP Agirbasli, M (corresponding author), Yesilbahar Sok 68-14 Goztepe, TR-34726 Istanbul, Turkey.
EM magirbasli@gmail.com
RI Agirbasli, Mehmet/AFP-1794-2022; Sunbul, Murat/AAS-5797-2020
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NR 82
TC 5
Z9 5
U1 0
U2 8
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1381-6128
EI 1873-4286
J9 CURR PHARM DESIGN
JI Curr. Pharm. Design
PD FEB
PY 2014
VL 20
IS 4
BP 529
EP 535
DI 10.2174/138161282004140213124141
PG 7
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA AE9DV
UT WOS:000334305800006
PM 23565636
DA 2025-06-11
ER

PT J
AU Boersma, G
   Benthem, L
   van Dijk, G
   Steimer, TJ
   Scheurink, AJW
AF Boersma, Gretha
   Benthem, Lambertus
   van Dijk, Gertjan
   Steimer, Thierry J.
   Scheurink, Anton J. W.
TI Pharmacological treatment of hyperinsulineamia in rats depends on coping
   style
SO EUROPEAN JOURNAL OF PHARMACOLOGY
LA English
DT Article
DE Rosiglitazone; RU486; Glucocorticoid; PPAR gamma agonist; Intravenous
   glucose tolerance test
ID ROMAN HIGH-AVOIDANCE; INSULIN-RESISTANCE; METABOLIC SYNDROME; FAT;
   GLUCOSE; STRESS; PATTERNS; INFUSION; MUSCLE; RU-486
AB Passive and proactive coping styles are associated with marked differences in behavioral and neuroendocrine responses. Previous studies revealed that the passive individuals are more prone to hyperinsulineamia. Likewise, we hypothesize that different coping styles may require different drugs to treat this. We tested this by treating passive and proactive rats (Roman Low Avoidance and Roman High Avoidance rats respectively) with either Rosiglitazone or with RU486. After eight days of treatment we performed and intravenous glucose tolerance test (IVGTT) and we compared the insulin and glucose levels with those measured during the IVGTT at baseline. Rosiglitazone improved insulin levels during an IVGTT in both passive and proactive coping styles. RU486, however, lowered insulin levels only in rats with a passive coping style. This study suggests that insight in the neuroendocrine differences between passive and proactive coping styles may provide an extra impulse to improve treatment of insulin resistance, since it allows the application of drugs targeted at the individual. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Boersma, Gretha; van Dijk, Gertjan; Scheurink, Anton J. W.] Univ Groningen, Dept Neuroendocrinol, NL-9750 AA Haren, Netherlands.
   [Benthem, Lambertus] AstraZeneca, Dept Res & Dev, Sodertalje, Sweden.
   [Steimer, Thierry J.] Univ Geneva, Dept Psychopharmacol, CH-1211 Geneva 4, Switzerland.
C3 University of Groningen; AstraZeneca; University of Geneva
RP Boersma, G (corresponding author), Univ Groningen, Dept Neuroendocrinol, POB 14, NL-9750 AA Haren, Netherlands.
EM g.j.boersma@rug.nl; Bert.Benthem@astrazeneca.com;
   gertjan.van.dijk@rug.nl; Thierry.Steimer@hcuge.ch;
   A.J.W.Scheurink@rug.nl
OI van Dijk, Gertjan/0000-0002-6565-4019
FU AstraZeneca
FX We would like to thank Jan Bruggink for his excellent technical support.
   These studies were supported by an unrestricted research grant by
   AstraZeneca.
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NR 24
TC 7
Z9 7
U1 0
U2 4
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0014-2999
J9 EUR J PHARMACOL
JI Eur. J. Pharmacol.
PD MAR 1
PY 2011
VL 654
IS 1
BP 122
EP 127
DI 10.1016/j.ejphar.2010.12.017
PG 6
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 720OY
UT WOS:000287291200018
PM 21185824
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Chen, SQ
   Zheng, DY
   Wang, H
AF Chen, Shuqi
   Zheng, Danyang
   Wang, Hao
TI Research progress on the pathogenesis of androgenetic alopecia
SO EUROPEAN JOURNAL OF DERMATOLOGY
LA English
DT Article
DE androgenetic alopecia (AGA); male-pattern baldness; AGA genetics;
   androgen metabolism; pathogenesis
ID DERMAL PAPILLA CELLS; WNT/BETA-CATENIN; HAIR-FOLLICLES; RECEPTOR;
   EXPRESSION; APOPTOSIS; GROWTH; MEN; DIFFERENTIATION; IDENTIFICATION
AB Androgenetic alopecia is a common, dermatological, chronic, non-cicatricial hair loss disorder, characterized by progressive hair follicular miniaturization. Although androgenetic alopecia is a benign condition, it can have a significant impact on patients' self-esteem, mood and quality of life. There are currently two FDA-approved drugs for androgenetic alopecia; topical minoxidil and finasteride. However, some patients with these two drugs show little improvement in hair loss. Thus, there is an urgent need to clarify the mechanisms involved and treatment methods. Studies have shown that the pathogenesis of androgenetic alopecia involves many aspects, among which a genetic factor is most important in determining the individual differences between androgenetic alopecia patients. An abnormal increase in 5-alpha reductase and androgenetic receptors in hair follicles plays a decisive role in the pathogenesis of androgenetic alopecia. Microinflammation of hair follicles, changes in the state of oxidative stress, loss of hair follicle stem cells, and metabolic syndrome are also associated with androgenetic alopecia. We review the complex mechanism of androgenic alopecia, providing insight into the possible direction of future research.
C1 [Chen, Shuqi; Zheng, Danyang; Wang, Hao] Xi An Jiao Tong Univ, Dept Dermatol, Affiliated Hosp 2, Xian, Shaanxi, Peoples R China.
C3 Xi'an Jiaotong University
RP Wang, H (corresponding author), Xi An Jiao Tong Univ, Dept Dermatol, Affiliated Hosp 2, Xian, Shaanxi, Peoples R China.
EM 18235150599@163.com
RI Zheng, Danyang/JCE-4101-2023
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NR 67
TC 0
Z9 0
U1 14
U2 14
PU JLE
PI ARCUEIL
PA 30, RUE BERTHOLLET, BATIMENT A, 94110 ARCUEIL, ?, FRANCE
SN 1167-1122
EI 1952-4013
J9 EUR J DERMATOL
JI Eur. J. Dermatol.
PD JAN-FEB
PY 2025
VL 35
IS 1
BP 3
EP 8
DI 10.1684/ejd.2025.4815
PG 6
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 0YY3H
UT WOS:001459342700001
PM 40110814
DA 2025-06-11
ER

PT J
AU Ahn, Y
   Aung, N
   Ahn, HS
AF Ahn, Yuran
   Aung, Nay
   Ahn, Hyo-Suk
TI A Comprehensive Review of Clinical Studies Applying Flow-Mediated
   Dilation
SO DIAGNOSTICS
LA English
DT Review
DE flow-mediated dilation (FMD); endothelial function
ID CORONARY-ARTERY-DISEASE; IMPROVES ENDOTHELIAL FUNCTION; VASCULAR
   FUNCTION; SHEAR-STRESS; HYPERTENSIVE PATIENTS; METABOLIC SYNDROME;
   BRACHIAL-ARTERY; ILIAC ARTERY; GLYCOCALYX; DYSFUNCTION
AB Flow-mediated dilation (FMD) is a noninvasive method to evaluate vascular endothelial function, which manifests the vascular inflammatory response, cell proliferation, and autoregulation. Since FMD is noninvasive and assesses commonly in the brachial artery by ultrasound, compared to other invasive methods such as optical coherence tomography (OCT) and intravascular ultrasound (IVUS), it is widely used to evaluate endothelial function and allows serial assessment. In this review, we present the currently accepted mechanisms and methods of FMD measurement with the studies applied in the current clinical practice using FMD. After all, the association with cardiovascular diseases is of substance, and so we introduce clinical studies of FMD related to cardiovascular disease such as diabetes, hyperlipidemia, chronic kidney disease, coronary artery disease, and peripheral vascular disease. In addition, studies related to pregnancy and COVID-19 were also inspected. Yet, endothelial examination is not endorsed as a cardiovascular prevention measure, for the lack of a clear standardized value methodology. Still, many studies recommend practicable FMD and would be a better prognostic value in the cardiovascular prognosis in future clinical research.
C1 [Ahn, Yuran; Ahn, Hyo-Suk] Catholic Univ Korea, Uijeongbu St Marys Hosp, Dept Internal Med, Div Cardiol, Seoul 06591, South Korea.
   [Ahn, Yuran; Ahn, Hyo-Suk] Catholic Univ Korea, Catholic Res Inst Intractable Cardiovasc Dis CRID, Coll Med, Seoul 06591, South Korea.
   [Aung, Nay] Queen Mary Univ London, William Harvey Res Inst, Barts & London Sch Med & Dent, London E1 2AD, England.
   [Aung, Nay] Queen Mary Univ London, Natl Inst Hlth & Care Res, Barts Cardiovasc Biomed Res Ctr, London E1 4NS, England.
   [Aung, Nay] St Bartholomews Hosp, Barts Hlth NHS Trust, Dept Cardiol, Barts Heart Ctr, London EC1A 7BE, England.
C3 Catholic University of Korea; Catholic University of Korea; University
   of London; Queen Mary University London; University of London; Queen
   Mary University London; University of London; Queen Mary University
   London; Barts Health NHS Trust
RP Ahn, HS (corresponding author), Catholic Univ Korea, Uijeongbu St Marys Hosp, Dept Internal Med, Div Cardiol, Seoul 06591, South Korea.; Ahn, HS (corresponding author), Catholic Univ Korea, Catholic Res Inst Intractable Cardiovasc Dis CRID, Coll Med, Seoul 06591, South Korea.
EM niceayr@naver.com; n.aung@qmul.ac.kr; alaco0502@gmail.com
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NR 92
TC 2
Z9 2
U1 1
U2 1
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2075-4418
J9 DIAGNOSTICS
JI Diagnostics
PD NOV
PY 2024
VL 14
IS 22
AR 2499
DI 10.3390/diagnostics14222499
PG 15
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA N4V5C
UT WOS:001364334800001
PM 39594169
OA gold
DA 2025-06-11
ER

PT J
AU Lee, YA
   Friedman, SL
AF Lee, Youngmin A.
   Friedman, Scott L.
TI Inflammatory and fibrotic mechanisms in NAFLD-Implications for new
   treatment strategies
SO JOURNAL OF INTERNAL MEDICINE
LA English
DT Review
DE fibrosis; insulin resistance; lipotoxicity; liver cancer; nonalcoholic
   fatty liver disease; nonalcoholic steatohepatitis
ID FATTY LIVER-DISEASE; HEPATIC STELLATE CELLS; NONALCOHOLIC
   STEATOHEPATITIS; ER STRESS; INSULIN SENSITIVITY; GASTRIC BYPASS; GUT
   MICROBIOTA; INTESTINAL MICROBIOTA; METABOLIC SYNDROME; LIPID-METABOLISM
AB Non-alcoholic fatty liver disease is comprised of either simple steatosis (non-alcoholic fatty liver) or a more advanced inflammatory and fibrogenic stage (non-alcoholic steatohepatitis [NASH]). NASH affects a growing proportion of the global adult and pediatric population, leading to rising rates of liver fibrosis and hepatocellular carcinoma. NASH is a multifactorial disease that is part of a systemic metabolic disorder. Here, we provide an overview of the metabolic underpinnings of NASH pathogenesis and established drivers of inflammation and fibrosis. Clarification of underlying fibrogenic and inflammatory mechanisms will advance the development of novel treatment strategies as there are no approved therapies at present. We discuss emerging experimental approaches and potential novel investigational strategies derived from animal models including the inflammasome, epigenetic reprogramming, Hippo signaling, Notch signaling, engineered T cells to remove fibrogenic HSCs, and HSC-specific targeting therapies. Recently completed and ongoing clinical trials and antifibrotics are discussed, illuminating the growing expectation that one or more therapies will yield clinical benefit in NASH in the coming years.
C1 [Lee, Youngmin A.] Vanderbilt Univ, Dept Surg, Med Ctr, 2213 Garland Ave, Nashville, TN 37232 USA.
   [Friedman, Scott L.] Icahn Sch Med Mt Sinai, Div Liver Dis, New York, NY 10029 USA.
C3 Vanderbilt University; Icahn School of Medicine at Mount Sinai
RP Lee, YA (corresponding author), Vanderbilt Univ, Dept Surg, Med Ctr, 2213 Garland Ave, Nashville, TN 37232 USA.
EM Youngmin.Lee@vumc.org
RI Lee, Youngmin/KYQ-3944-2024; Friedman, Scott/AFV-6304-2022
OI Friedman, Scott/0000-0003-1178-6195
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TC 66
Z9 67
U1 1
U2 32
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0954-6820
EI 1365-2796
J9 J INTERN MED
JI J. Intern. Med.
PD JAN
PY 2022
VL 291
IS 1
BP 11
EP 31
DI 10.1111/joim.13380
EA SEP 2021
PG 21
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA XP8SO
UT WOS:000699445300001
PM 34564899
OA Bronze, Green Accepted
DA 2025-06-11
ER

PT J
AU Burra, P
   Bizzaro, D
   Gonta, A
   Shalaby, S
   Gambato, M
   Morelli, MC
   Trapani, S
   Floreani, A
   Marra, F
   Brunetto, MR
   Taliani, G
   Villa, E
AF Burra, Patrizia
   Bizzaro, Debora
   Gonta, Anna
   Shalaby, Sarah
   Gambato, Martina
   Morelli, Maria Cristina
   Trapani, Silvia
   Floreani, Annarosa
   Marra, Fabio
   Brunetto, Maurizia Rossana
   Taliani, Gloria
   Villa, Erica
CA Italian Assoc Study Liver AISF
TI Clinical impact of sexual dimorphism in non-alcoholic fatty liver
   disease (NAFLD) and non-alcoholic steatohepatitis (NASH)
SO LIVER INTERNATIONAL
LA English
DT Review
DE acute-on-chronic liver failure; chronic kidney disease; HCC; liver
   disease; liver transplantation; NAFLD; NASH; sex dimorphism
ID HORMONE-BINDING GLOBULIN; SERUM ALANINE AMINOTRANSFERASE;
   POLYCYSTIC-OVARY-SYNDROME; LIFE-STYLE MODIFICATION; BODY-MASS INDEX;
   HEPATOCELLULAR-CARCINOMA; RISK-FACTORS; UNITED-STATES; METABOLIC
   SYNDROME; HEPATIC STEATOSIS
AB NAFLD/NASH is a sex-dimorphic disease, with a general higher prevalence in men. Women are at reduced risk of NAFLD compared to men in fertile age, whereas after menopause women have a comparable prevalence of NAFLD as men. Indeed, sexual category, sex hormones and gender habits interact with numerous NAFLD factors including cytokines, stress and environmental factors and alter the risk profiles and phenotypes of NAFLD. In the present review, we summarized the last findings about the influence of sex on epidemiology, pathogenesis, progression in cirrhosis, indication for liver transplantation and alternative therapies, including lifestyle modification and pharmacological strategies. We are confident that an appropriate consideration of sex, age, hormonal status and sociocultural gender differences will lead to a better understanding of sex differences in NAFLD risk, therapeutic targets and treatment responses and will aid in achieving sex-specific personalized therapies.
C1 [Burra, Patrizia; Bizzaro, Debora; Gonta, Anna; Shalaby, Sarah; Gambato, Martina] Univ Hosp Padua, Dept Surg Oncol & Gastroenterol, Multivisceral Transplant Unit, Via Giustiniani 2, I-35128 Padua, Italy.
   [Morelli, Maria Cristina] Azienda Osped Univ Bologna, Bologna, Italy.
   [Trapani, Silvia] Italian Natl Inst Hlth, Italian Natl Transplant Ctr, Rome, Italy.
   [Floreani, Annarosa] Univ Padua, Padua, Italy.
   [Floreani, Annarosa] IRCCS Osped Sacro Cuore Don Calabria, Negrar, Italy.
   [Marra, Fabio] Univ Florence, Dept Expt & Clin Med, Florence, Italy.
   [Brunetto, Maurizia Rossana] Univ Pisa, Dept Clin & Expt Med, Hepatol & Liver Physiopathol Lab & Internal Med, Pisa, Italy.
   [Taliani, Gloria] Sapienza Univ Rome, Dept Translat & Precis Med, Infect Dis Unit, Rome, Italy.
   [Villa, Erica] Azienda Osped Univ Policlin Modena, Gastroenterol Unit, Modena, Italy.
C3 University of Padua; Azienda Ospedaliera - Universita di Padova; IRCCS
   Azienda Ospedaliero-Universitaria di Bologna; Istituto Superiore di
   Sanita (ISS); University of Padua; IRCCS Sacro Cuore Don Calabria;
   University of Florence; University of Pisa; Sapienza University Rome;
   Universita di Modena e Reggio Emilia; Universita di Modena e Reggio
   Emilia Hospital
RP Burra, P (corresponding author), Univ Hosp Padua, Dept Surg Oncol & Gastroenterol, Multivisceral Transplant Unit, Via Giustiniani 2, I-35128 Padua, Italy.
EM burra@unipd.it
RI Brunetto, Maurizia/AAU-2906-2020; Shalaby, Sarah/AAX-3860-2020; Burra,
   Patrizia/AAB-2448-2019; Marra, Fabio/K-7263-2016; Bizzaro,
   Debora/K-4570-2016; Villa, Erica/A-7576-2012
OI Marra, Fabio/0000-0001-8629-0878; Bizzaro, Debora/0000-0002-5808-9285;
   SHALABY, SARAH/0000-0002-8700-6282; Burra, Patrizia/0000-0002-8791-191X;
   morelli, maria cristina/0000-0002-9742-1981; Villa,
   Erica/0000-0001-6388-7022
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NR 204
TC 104
Z9 107
U1 4
U2 20
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1478-3223
EI 1478-3231
J9 LIVER INT
JI Liver Int.
PD AUG
PY 2021
VL 41
IS 8
BP 1713
EP 1733
DI 10.1111/liv.14943
EA JUN 2021
PG 21
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA TJ5VF
UT WOS:000658796500001
PM 33982400
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Xi, D
   Bhattacharjee, J
   Salazar-Gonzalez, RM
   Park, S
   Jang, A
   Warren, M
   Merritt, R
   Michail, S
   Bouret, S
   Kohli, R
AF Xi, Dong
   Bhattacharjee, Jashdeep
   Salazar-Gonzalez, Rosa-Maria
   Park, Soyoung
   Jang, Alice
   Warren, Mikako
   Merritt, Russell
   Michail, Sonia
   Bouret, Sebastien
   Kohli, Rohit
TI Rebaudioside affords hepatoprotection ameliorating sugar sweetened
   beverage- induced nonalcoholic steatohepatitis
SO SCIENTIFIC REPORTS
LA English
DT Article
ID METABOLIC SYNDROME; GUT MICROBIOME; STEVIOSIDE; STEVIA; CONSUMPTION;
   RISK; MICE; INFLAMMATION; STIMULATION; SACCHARIN
AB Sugar-sweetened beverage consumption is a known independent risk factor for nonalcoholic steatohepatitis (NASH). Non-caloric sweeteners (NCS) are food additives providing sweetness without calories and are considered safe and/or not metabolized by the liver. The potential role of newer NCS in the regulation of NASH, however, remain unknown. Our study aimed to determine the impact of newer NCS including Rebaudioside A and sucralose on NASH using high fat diet induced obesity mouse model by substituting fructose and sucrose with NCS in the drinking water. We characterized the phenotype of NCS- treated obesity and investigated the alterations of hepatic function and underlying mechanisms. We found that NCS have no impact on weight gain and energy balance in high fat diet induced obesity. However, in comparison to fructose and sucrose, Rebaudioside A significantly improved liver enzymes, hepatic steatosis and hepatic fibrosis. Additionally, Rebaudioside A improved endoplasmic reticulum (ER) stress related gene expressions, fasting glucose levels, insulin sensitivity and restored pancreatic islet cell mass, neuronal innervation and microbiome composition. We concluded that Rebaudioside A significantly ameliorated murine NASH, while the underlying mechanisms requires further investigation.
C1 [Xi, Dong; Bhattacharjee, Jashdeep; Salazar-Gonzalez, Rosa-Maria; Merritt, Russell; Michail, Sonia; Kohli, Rohit] Gastroenterol Hepatol & Nutr, Los Angeles, CA 90027 USA.
   [Park, Soyoung; Jang, Alice; Bouret, Sebastien] Ctr Endocrinol Diabet & Metab, Dev Neurosci Program, Richmond, VA 23298 USA.
   [Park, Soyoung; Jang, Alice; Bouret, Sebastien] Ctr Endocrinol Diabet & Metab, Diabet & Obes Program, Richmond, VA 23298 USA.
   [Warren, Mikako] Childrens Hosp Los Angeles, Pathol & Lab Med, Los Angeles, CA 90027 USA.
   [Warren, Mikako] Univ Southern Calif, Keck Sch Med, Los Angeles, CA 90027 USA.
C3 Children's Hospital Los Angeles; University of Southern California
RP Kohli, R (corresponding author), Gastroenterol Hepatol & Nutr, Los Angeles, CA 90027 USA.
EM rokohli@chla.usc.edu
RI Bhattacharjee, Jashdeep/AAH-4088-2019; Warren, Mikako/AAN-4062-2021;
   Bouret, Sebastien/AAG-7120-2021; kohli, Rohit/H-3020-2013
OI kohli, Rohit/0000-0002-0198-7703; Park, Soyoung/0000-0001-8129-9064
FU NIH [DK100314]; Stanley Ekstrom Foundation
FX This study was supported by NIH grant DK100314 (RK) and a research grant
   from the Stanley Ekstrom Foundation. We thank CHLA pathology research
   core, CHLA metabolic core, CHLA SC2 Core and USC microbiome core for
   their technical support.
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NR 53
TC 17
Z9 17
U1 5
U2 23
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD APR 21
PY 2020
VL 10
IS 1
AR 6689
DI 10.1038/s41598-020-63688-z
PG 11
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA NA4CO
UT WOS:000559762800013
PM 32317687
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Jiang, N
   Li, Y
   Shu, T
   Wang, J
AF Jiang, Ning
   Li, Yao
   Shu, Ting
   Wang, Jing
TI Cytokines and inflammation in adipogenesis: an updated review
SO FRONTIERS OF MEDICINE
LA English
DT Review
DE cytokines; inflammation; adipogenesis; type 2 diabetes mellitus;
   metabolic disorder
ID TUMOR-NECROSIS-FACTOR; ADIPOSE-TISSUE INFLAMMATION; INDUCED
   INSULIN-RESISTANCE; NF-KAPPA-B; MONOCYTE CHEMOATTRACTANT PROTEIN-1;
   ENDOPLASMIC-RETICULUM STRESS; ACTIVATED RECEPTOR-GAMMA; INHIBITS
   ADIPOCYTE DIFFERENTIATION; OBESITY-INDUCED INFLAMMATION; TNF-ALPHA
AB The biological relevance of cytokines is known for more than 20 years. Evidence suggests that adipogenesis is one of the biological events involved in the regulation of cytokines, and pro-inflammatory cytokines (e.g., TNF and IL-1) inhibit adipogenesis through various pathways. This inhibitory effect can constrain the hyperplastic expandability of adipose tissues. Meanwhile, chronic low-grade inflammation is commonly observed in obese populations. In some individuals, the impaired ability of adipose tissues to recruit new adipocytes to adipose depots during overnutrition results in adipocyte hypertrophy, ectopic lipid accumulation, and insulin resistance. Intervention studies showed that pro-inflammatory cytokine antagonists improve metabolism in patients with metabolic syndrome. This review focuses on the cytokines currently known to regulate adipogenesis under physiological and pathophysiological circumstances. Recent studies on how inhibited adipogenesis leads to metabolic disorders were summarized. Although the interplay of cytokines and lipid metabolism is yet incompletely understood, cytokines represent a class of potential therapeutic targets in the treatment of metabolic disorders.
C1 [Jiang, Ning; Li, Yao; Shu, Ting; Wang, Jing] Chinese Acad Med Sci, Inst Basic Med Sci, State Key Lab Med Mol Biol, Dept Pathophysiol,Peking Union Med Coll, Beijing 100730, Peoples R China.
C3 Chinese Academy of Medical Sciences - Peking Union Medical College;
   Peking Union Medical College
RP Wang, J (corresponding author), Chinese Acad Med Sci, Inst Basic Med Sci, State Key Lab Med Mol Biol, Dept Pathophysiol,Peking Union Med Coll, Beijing 100730, Peoples R China.
EM wangjing@ibms.pumc.edu.cn
OI Jiang, Ning/0000-0002-1212-0291
FU National Natural Science Foundation of China [81622008, 81470579]
FX This study was financially supported by the National Natural Science
   Foundation of China (Nos. 81622008 and 81470579) (to Jing Wang).
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NR 189
TC 70
Z9 74
U1 1
U2 39
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 2095-0217
EI 2095-0225
J9 FRONT MED-PRC
JI Front. Med.
PD JUN
PY 2019
VL 13
IS 3
BP 314
EP 329
DI 10.1007/s11684-018-0625-0
PG 16
WC Oncology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Research & Experimental Medicine
GA IC7VD
UT WOS:000471184700003
PM 30066061
DA 2025-06-11
ER

PT J
AU Kolbe, I
   Oster, H
AF Kolbe, Isa
   Oster, Henrik
TI Chronodisruption, Metabolic Homeostasis, and the Regulation of
   Inflammation in Adipose Tissues
SO YALE JOURNAL OF BIOLOGY AND MEDICINE
LA English
DT Review
ID HIGH-FAT DIET; CIRCADIAN ENERGY-METABOLISM; REV-ERB-ALPHA; OXIDATIVE
   STRESS; SLEEP-DEPRIVATION; BODY-MASS; DIM LIGHT; INSULIN SENSITIVITY;
   GLUCOSE-TOLERANCE; RISK-FACTORS
AB Molecular circadian clocks align daily behavioral and metabolic rhythms with the external day-night cycle. Priming energy metabolism for recurring changes on a 24-hour basis, these clocks are deeply interlinked with metabolic homeostasis and health. Circadian rhythm disruptions, as occurring in shift work or sleep disorders, are often accompanied by metabolic disturbances - from the promotion of overweight and type-2 diabetes to the development of the metabolic syndrome. An important indicator of the adverse outcomes of overweight seems to be a systemic low-grade inflammation which is initially observed in adipose tissues and is promoted by circadian misalignment. Interestingly, the genetic disruption of circadian clocks in rodents leads to metabolic dysregulations very comparable to what is observed in shift workers and with the development of tissue specific clock gene knockout mice, the importance of single-tissue clocks for the metabolic regulation was further deciphered. In this review, we summarize the current knowledge on the role of mistimed behavior in metabolic health and outline behavioral interventions aiming at reducing the metabolic ramifications of chronodisruption.
C1 [Kolbe, Isa; Oster, Henrik] Univ Lubeck, Inst Neurobiol, CBBM House 66,Marie Curie St, D-23562 Lubeck, Germany.
C3 University of Lubeck
RP Oster, H (corresponding author), Univ Lubeck, Inst Neurobiol, CBBM House 66,Marie Curie St, D-23562 Lubeck, Germany.
EM henrik.oster@uni-luebeck.de
RI Oster, Henrik/D-2335-2013
OI Oster, Henrik/0000-0002-1414-7068
FU German Research Foundation (DFG) [GRK-1957, OS353-7/1]; Lichtenberg
   Fellowship of the Volkswagen Foundation
FX This work was funded by grants of the German Research Foundation (DFG;
   GRK-1957 & OS353-7/1) and a Lichtenberg Fellowship of the Volkswagen
   Foundation (HO).
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NR 112
TC 22
Z9 25
U1 2
U2 5
PU YALE J BIOLOGY MEDICINE, INC
PI NEW HAVEN
PA 333 CEDAR ST, PO BOX 208000, NEW HAVEN, CT 06520-8000 USA
SN 0044-0086
EI 1551-4056
J9 YALE J BIOL MED
JI Yale J. Biol. Med.
PD JUN
PY 2019
VL 92
IS 2
BP 317
EP 325
PG 9
WC Biology; Medicine, General & Internal; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics; General & Internal Medicine;
   Research & Experimental Medicine
GA IF4YJ
UT WOS:000473087800018
PM 31249492
DA 2025-06-11
ER

PT J
AU Dowling, D
   McAuliffe, FM
AF Dowling, Daniel
   McAuliffe, Fionnuala M.
TI The Molecular Mechanisms of Offspring Effects from Obese Pregnancy
SO OBESITY FACTS
LA English
DT Review
DE Maternal obesity; Epigenetics; Reactive oxygen species
ID HYPOTHALAMIC FEEDING CIRCUITS; NITRIC-OXIDE; MATERNAL OBESITY; CARDIAC
   FIBROBLASTS; INSULIN-RESISTANCE; METABOLIC SYNDROME; OXIDATIVE STRESS;
   ANGIOTENSIN-II; PREIMPLANTATION EMBRYOS; DEVELOPMENTAL ORIGINS
AB The incidence of obesity, increased weight gain and the popularity of high-fat / high-sugar diets are seriously impacting upon the global population. Billions of individuals are affected, and although diet and lifestyle are of paramount importance to the development of adult obesity, compelling evidence is emerging which suggests that maternal obesity and related disorders may be passed on to the next generation by non-genetic means. The processes acting within the uteri of obese mothers may permanently predispose offspring to a diverse plethora of diseases ranging from obesity and diabetes to psychiatric disorders. This review aims to summarise some of the molecular mechanisms and active processes currently known about maternal obesity and its effect on foetal and neonatal physiology and metabolism. Complex and multifactorial networks of molecules are intertwined and culminate in a pathologically synergistic manner to cause disruption and disorganisation of foetal physiology. This altered phenotype may potentiate the cycle of intergenerational transmission of obesity and related disorders. Copyright (C) 2013 S. Karger GmbH, Freiburg
C1 [Dowling, Daniel; McAuliffe, Fionnuala M.] Univ Coll Dublin, Natl Matern Hosp, Sch Med & Med Sci, UCD Obstet & Gynaecol, Dublin 2, Ireland.
C3 National Maternity Hospital, Dublin; University College Dublin
RP McAuliffe, FM (corresponding author), Univ Coll Dublin, Natl Matern Hosp, Sch Med & Med Sci, UCD Obstet & Gynaecol, Dublin 2, Ireland.
EM Fionnuala.mcauliffe@ucd.ie
OI mcauliffe, fionnuala/0000-0002-3477-6494
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NR 89
TC 7
Z9 7
U1 0
U2 16
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1662-4025
EI 1662-4033
J9 OBESITY FACTS
JI Obes. Facts
PD APR
PY 2013
VL 6
IS 2
BP 134
EP 145
DI 10.1159/000350706
PG 12
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 137ZT
UT WOS:000318478500004
PM 23571656
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Stepp, DW
AF Stepp, DW
TI Impact of obesity and insulin resistance on vasomotor tone: Nitric oxide
   and beyond
SO CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
LA English
DT Review
DE adrenergic; angiotensin II; endothelin; endothelium; insulin resistance;
   sympathetic
ID ENDOTHELIUM-DEPENDENT RELAXATION; SYMPATHETIC-NERVE ACTIVITY; MUSCLE
   GLUCOSE-UPTAKE; PPAR-GAMMA AGONIST; PROTEIN-KINASE-C; SKELETAL-MUSCLE;
   OXIDATIVE STRESS; VASCULAR REACTIVITY; METABOLIC SYNDROME;
   ANGIOTENSIN-II
AB 1. Obesity is rapidly increasing in Western populations, driving a parallel increase in hypertension, diabetes and vascular disease. Prior to the development of overt diabetes or hypertension, obese patients spend years in a state of progressive insulin resistance and metabolic disease. Mounting evidence suggests that this insulin-resistant state has deleterious effects on the control of blood flow, thus placing organ systems at a higher risk for end-organ damage and increasing cardiovascular mortality.
   2. The purpose of the present review is to examine the current literature on the effects of obesity and insulin resistance on the acute control of vascular tone. Effects on nitric oxide (NO)-mediated control of vascular tone are particularly examined with regard to proximal causes and distal mechanisms of the impaired NO-mediation of vasodilation.
   3. Finally, novel pathways of impaired control of perfusion are summarized from the recent literature to identify new avenues of exploring impaired vascular function in patients with metabolic disease.
C1 Med Coll Georgia, Vasc Biol Ctr, Augusta, GA 30912 USA.
C3 University System of Georgia; Augusta University
RP Med Coll Georgia, Vasc Biol Ctr, 1459 Laney Walker Blvd, Augusta, GA 30912 USA.
EM dstepp@mail.mcg.edu
RI Stepp, David/F-4250-2011
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NR 129
TC 37
Z9 39
U1 0
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0305-1870
EI 1440-1681
J9 CLIN EXP PHARMACOL P
JI Clin. Exp. Pharmacol. Physiol.
PD MAY-JUN
PY 2006
VL 33
IS 5-6
BP 407
EP 414
DI 10.1111/j.1440-1681.2006.04381.x
PG 8
WC Pharmacology & Pharmacy; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Physiology
GA 040YY
UT WOS:000237420800001
PM 16700872
DA 2025-06-11
ER

PT J
AU Wang, LM
   Yang, Y
   Sun, HB
   Fei, MX
AF Wang, Liming
   Yang, Yan
   Sun, Haibing
   Fei, Mengxue
TI Magnoflorine alleviates nonalcoholic fatty liver disease by modulating
   lipid metabolism, mitophagy and inflammation
SO PROSTAGLANDINS & OTHER LIPID MEDIATORS
LA English
DT Article
DE Nonalcoholic fatty liver disease; Magnoflorine; Mitophagy; NLRP3
   inflammasome; Lipid metabolism
ID OXIDATIVE STRESS; PATHOPHYSIOLOGY
AB Background: Nonalcoholic fatty liver disease (NAFLD) is a prevalent liver condition associated with metabolic syndrome, often aggravated by inflammation and mitochondrial dysfunction. This study aims to explore the therapeutic potential of magnoflorine, an alkaloid with known anti-inflammatory properties, in ameliorating NAFLD by modulating mitochondrial autophagy and inhibiting the NLRP3 inflammasome. Methods: Male C57BL/6 J mice were fed a high-fat diet (HFD) for 16 weeks to induce NAFLD. Magnoflorine (5 and 10 mg/kg) was administered by gavage daily for 16 weeks. Liver and serum samples were analyzed for lipid profiles, inflammation markers, and autophagy-related proteins, and liver histology was examined to assess changes. results: Magnoflorine treatment improved dyslipidemia in NAFLD mice, shown by decreased serum triglycerides, total cholesterol, and LDL-C, and increased HDL-C. Histological analysis showed reduced hepatic steatosis and inflammation, with less lipid droplet accumulation and hepatocyte ballooning. Western blot results indicated upregulation of Parkin and PINK1, and downregulation of NLRP3, ASC, and caspase-1, with lower serum IL-1(3 levels, reflecting reduced inflammation. Conclusions: Magnoflorine offers a promising approach for mitigating NAFLD progression through modulating mitochondrial autophagy and inhibiting inflammation.
C1 [Wang, Liming; Yang, Yan; Sun, Haibing; Fei, Mengxue] Second Peoples Hosp Hefei, Dept Endocrinol, Guangde Rd, Hefei 230000, Anhui, Peoples R China.
RP Wang, LM (corresponding author), Second Peoples Hosp Hefei, Dept Endocrinol, Guangde Rd, Hefei 230000, Anhui, Peoples R China.
EM wlm810903@126.com
RI Wang, Liming/M-7381-2019
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NR 31
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1098-8823
EI 2212-196X
J9 PROSTAG OTH LIPID M
JI Prostaglandins Other Lipid Mediat.
PD JUN
PY 2025
VL 178
AR 106997
DI 10.1016/j.prostaglandins.2025.106997
PG 9
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA 3DT0Z
UT WOS:001497907500001
PM 40378915
DA 2025-06-11
ER

PT J
AU Gonzalez-Cano, SI
   Flores, G
   Guevara, J
   Morales-Medina, JC
   Treviño, S
   Diaz, A
AF Gonzalez-Cano, Sonia Irais
   Flores, Gonzalo
   Guevara, Jorge
   Morales-Medina, Julio Cesar
   Trevino, Samuel
   Diaz, Alfonso
TI Polyoxidovanadates a new therapeutic alternative for neurodegenerative
   and aging diseases
SO NEURAL REGENERATION RESEARCH
LA English
DT Review
DE Alzheimer's disease; antidiabetic; brain; cognition; diabetes; insulin;
   neurodegeneration; neuroinflammation; oxidative stress; Vanadium species
ID BRAIN INSULIN-RESISTANCE; ALZHEIMERS-DISEASE; VANADYL SULFATE; WISTAR
   RATS; G-ACTIN; METFORMIN; INHIBITION; IMPAIRMENT; EXPRESSION; COMPLEXES
AB Aging is a natural phenomenon characterized by a progressive decline in physiological integrity, leading to a deterioration of cognitive function and increasing the risk of suffering from chronic-degenerative diseases, including cardiovascular diseases, osteoporosis, cancer, diabetes, and neurodegeneration. Aging is considered the major risk factor for Parkinson's and Alzheimer's disease develops. Likewise, diabetes and insulin resistance constitute additional risk factors for developing neurodegenerative disorders. Currently, no treatment can effectively reverse these neurodegenerative pathologies. However, some antidiabetic drugs have opened the possibility of being used against neurodegenerative processes. In the previous framework, Vanadium species have demonstrated a notable antidiabetic effect. Our research group evaluated polyoxidovanadates such as decavanadate and metforminium-decavanadate with preventive and corrective activity on neurodegeneration in brain-specific areas from rats with metabolic syndrome. The results suggest that these polyoxidovanadates induce neuronal and cognitive restoration mechanisms. This review aims to describe the therapeutic potential of polyoxidovanadates as insulin-enhancer agents in the brain, constituting a therapeutic alternative for aging and neurodegenerative diseases.
C1 [Gonzalez-Cano, Sonia Irais; Trevino, Samuel; Diaz, Alfonso] Benemerita Autonomous Univ Puebla, Fac Chem Sci, Puebla, Mexico.
   [Flores, Gonzalo] Benemerita Autonomous Univ Puebla, Inst Physiol, Puebla, Mexico.
   [Guevara, Jorge] Univ Nacl Autonoma Mexico, Fac Med, Dept Biochem, Mexico City, Mexico.
   [Morales-Medina, Julio Cesar] Autonomous Univ Tlaxcala, Anim Reprod Res Ctr, CINVESTAV, Tlaxcala, Mexico.
C3 Benemerita Universidad Autonoma de Puebla; Benemerita Universidad
   Autonoma de Puebla; Universidad Nacional Autonoma de Mexico; CINVESTAV -
   Centro de Investigacion y de Estudios Avanzados del Instituto
   Politecnico Nacional
RP Diaz, A (corresponding author), Benemerita Autonomous Univ Puebla, Fac Chem Sci, Puebla, Mexico.
EM alfonso.diaz@correo.buap.mx
RI Flores, Gonzalo/B-1807-2014; Morales-Medina, Julio Cesar/ABE-3920-2021
OI Flores, Gonzalo/0000-0002-4100-2104; Diaz, Alfonso/0000-0003-4092-6636
FU National Research System (CONACYT), Mexico
FX This work was funded by project from National Research System (CONACYT),
   Mexico (to SIGC). CONACYT has no role in the writing or discussion of
   the present review.& nbsp;
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NR 98
TC 13
Z9 13
U1 6
U2 59
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, Maharashtra, INDIA
SN 1673-5374
EI 1876-7958
J9 NEURAL REGEN RES
JI Neural Regen. Res.
PD MAR
PY 2024
VL 19
IS 3
BP 571
EP 577
DI 10.4103/1673-5374.380877
PG 7
WC Cell Biology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Neurosciences & Neurology
GA P0GO2
UT WOS:001047511200030
PM 37721286
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Idris, IB
   Azit, NA
   Abdul Ghani, SR
   Syed Nor, SF
   Mohammed Nawi, A
AF Idris, Idayu Badilla
   Azit, Noor Atika
   Abdul Ghani, Siti Rasidah
   Syed Nor, Sharifah Fazlinda
   Mohammed Nawi, Azmawati
TI A systematic review on noncommunicable diseases among working women
SO INDUSTRIAL HEALTH
LA English
DT Review
DE Women; Working; NCD; Burden; Risk factors; Working hours
ID HEALTH; OBESITY
AB The increasing involvement of women in the paid-labor market has led to multifactorial exposure towards the development of noncommunicable diseases (NCDs). This review aims to identify the prevalence of NCDs and the associated risk factors among working women. A systematic review was performed using PubMed and Scopus databases. Twelve articles published between 2015 and 2019 satisfied the inclusion and exclusion criteria and were selected for qualitative synthesis. Among working women, the prevalence of NCDs was as follows: coronary heart disease, 0.3%-5.9%; metabolic syndrome, 52.0%; diabetes mellitus, 8.9%-16.0%; hypertension, 16.6%-66.4%; non-skin cancer, 3.7%. The prevalence of NCD risk factors was as follows: overweight/obesity, 33.8%-77.0%; low physical activity, 51.0%; unhealthy diet, 44.9%-69.9%; dyslipidemia, 27.8%-44.0%. The factors associated with NCDs were long working hours, double work burden, and stress. NCD is an important burden of working women that will lead to reduced work quality and affect family well-being. Disease prevention approaches, such as the intervention of common workplace risk factors and specific work schedule design, are among the strategies for improving the situation.
C1 [Idris, Idayu Badilla; Azit, Noor Atika; Abdul Ghani, Siti Rasidah; Syed Nor, Sharifah Fazlinda; Mohammed Nawi, Azmawati] Univ Kebangsaan Malaysia, Fac Med, Dept Community Hlth, Bangi, Malaysia.
C3 Universiti Kebangsaan Malaysia
RP Mohammed Nawi, A (corresponding author), Univ Kebangsaan Malaysia, Fac Med, Dept Community Hlth, Bangi, Malaysia.
EM azmawati@ppukm.ukm.edu.my
RI Idris, Idayu/AAI-3369-2021
OI idris, idayu badilla/0000-0002-7238-2904; Syed Nor, Sharifah
   Fazlinda/0000-0002-0348-7198
CR Al Saweer A, 2017, BAHRAIN MED B, V39, P216, DOI 10.12816/0047770
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   World Health Organization (WHO), 2016, WHO NCD WOM
NR 26
TC 9
Z9 9
U1 2
U2 9
PU NATL INST OCCUPATIONAL SAFETY & HEALTH, JAPAN
PI KAWASAKI KANAGAWA
PA 21-1 NAGAO 6-CHOME TAMA-KU, KAWASAKI KANAGAWA, 214, JAPAN
SN 0019-8366
EI 1880-8026
J9 IND HEALTH
JI Ind. Health
PY 2021
VL 59
IS 3
BP 146
EP 160
DI 10.2486/indhealth.2020-0204
PG 15
WC Environmental Sciences; Public, Environmental & Occupational Health;
   Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health; Toxicology
GA UC0MB
UT WOS:000686228400002
PM 33551443
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Kan, X
   Liu, GL
   Yang, Y
   Yang, QY
   Li, YP
   Wang, F
AF Kan, Xuan
   Liu, Geli
   Yang, Yong
   Yang, Qingyan
   Li, Yapu
   Wang, Feng
TI Serum vascular endothelial cadherin and thrombomodulin are markers of
   non-alcoholic fatty liver disease in children
SO JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
LA English
DT Article
DE non-alcoholic fatty liver disease; thrombomodulin; vascular endothelial
   cadherin
ID INTIMA-MEDIA THICKNESS; METABOLIC SYNDROME; OBESE CHILDREN; OXIDATIVE
   STRESS; URIC-ACID; ADOLESCENTS; ASSOCIATION; OVERWEIGHT; NAFLD
AB Background: The diagnosis of non-alcoholic fatty liver disease (NAFLD) is usually based on liver ultrasonography and serum alanine aminotransferase (ALT) levels. However, the serum ALT level is not sensitive for detecting NAFLD. If more serum markers are available, serum analysis may play a more important role in the diagnosis of NAFLD.
   Methods: Here, we have investigated whether vascular endothelial cadherin (VE-cad) and thrombomodulin (TM) are markers of NAFLD in children. After an examination of liver ultrasonography, 90 children were divided into a lean control group (n = 32), an overweight/obese NAFLD group (group-NAFLD, n = 34) and an overweight/obese non-NAFLD group (group-SOO, n = 24).
   Results: Two overweight/obese groups had similar obesity. However, serum VE-cad and TM levels were increased in group-NAFLD but not group-SOO. When data from all children were pooled, serum VE-cad and TM levels were positively correlated to body-mass index (BMI) and serum ALT levels.
   Conclusions: In conclusion, VE-cad and TM are markers of pediatric NAFLD.
C1 [Wang, Feng] Nankai Hosp, Tianjin Inst Integrat Med Acute Abdominal Dis, Changjiang Rd 6, Tianjin 300100, Peoples R China.
   [Kan, Xuan; Liu, Geli; Yang, Qingyan; Li, Yapu] Tianjin Med Univ, Gen Hosp, Dept Pediat, Tianjin, Peoples R China.
   [Yang, Yong] Ctr Dis Control, Tianjin, Peoples R China.
C3 Tianjin Medical University
RP Wang, F (corresponding author), Nankai Hosp, Tianjin Inst Integrat Med Acute Abdominal Dis, Changjiang Rd 6, Tianjin 300100, Peoples R China.
EM fengwangpi@163.com
FU Tianjin Medical University; Tianjin Municipal Government
FX We thank Tianjin Medical University and Tianjin Municipal Government for
   financial supports.
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NR 17
TC 5
Z9 5
U1 0
U2 3
PU WALTER DE GRUYTER GMBH
PI BERLIN
PA GENTHINER STRASSE 13, D-10785 BERLIN, GERMANY
SN 0334-018X
EI 2191-0251
J9 J PEDIATR ENDOCR MET
JI J. Pediatr. Endocrinol. Metab.
PD DEC
PY 2016
VL 29
IS 12
BP 1331
EP 1335
DI 10.1515/jpem-2015-0328
PG 5
WC Endocrinology & Metabolism; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Pediatrics
GA EE2TL
UT WOS:000389437300002
PM 26959535
DA 2025-06-11
ER

PT J
AU Takahashi, Y
   Ohoka, N
   Hayashi, H
   Sato, R
AF Takahashi, Yu
   Ohoka, Nobumichi
   Hayashi, Hidetoshi
   Sato, Ryuichiro
TI TRB3 suppresses adipocyte differentiation by negatively regulating PPARγ
   transcriptional activity
SO JOURNAL OF LIPID RESEARCH
LA English
DT Article
DE tribbles homolog 3; perilipin; triglyceride; 3T3-LI; peroxisome
   proliferator-activated receptor gamma
ID GENE-EXPRESSION; GLUCOSE-HOMEOSTASIS; INSULIN-RESISTANCE; METABOLIC
   SYNDROME; NUCLEAR RECEPTORS; TRIBBLES HOMOLOG; BINDING-PROTEIN;
   X-RECEPTOR; ER STRESS; ACTIVATION
AB In the course of an effort to identify the regulators for peroxisome proliferator-activated receptor gamma (PPAR gamma)-dependent perilipin gene expression, we found that tribbles homolog 3 (TRB3), containing a single kinase domain without enzymatic activity, downregulates PPAR gamma transcriptional activities by protein-protein interaction. We examined the role that TRB3 plays in adipocyte differentiation in 3T3-LI cells. TRB3 gene and protein expression was increased during adipocyte differentiation concomitantly with an increase in the mRNA levels of CCAAT/enhancer binding protein homologous protein. The physical interaction between TRB3 and PPAR gamma was also verified in 3T3-LI adipocytes. Forced TRB3 expression in 3T3-LI cells decreased the mRNA levels of PPAR gamma-target genes and intracellular triglyceride levels, whereas knockdown of TRB3 expression by RNA interference increased them. TRB3 also inhibits PPAR gamma-dependent adipocyte differentiation in lentivirus-mediated PPAR gamma-expressing 3T3-LI cells. These results provide evidence that TRB3 acts as a potent negative regulator of PPAR gamma, a master regulator of adipocyte differentiation, and tightly controls adipogenesis.
C1 [Hayashi, Hidetoshi] Nagoya City Univ, Grad Sch Pharmaceut Sci, Dept Mol Hlth Sci, Nagoya, Aichi 4678603, Japan.
   [Takahashi, Yu; Ohoka, Nobumichi; Sato, Ryuichiro] Univ Tokyo, Grad Sch Agr & Life Sci, Dept Appl Biol Chem, Tokyo 1138657, Japan.
   [Ohoka, Nobumichi; Sato, Ryuichiro] Basic Res Activ Innovat Biosci, Tokyo 1050001, Japan.
C3 Nagoya City University; University of Tokyo
RP Hayashi, H (corresponding author), Nagoya City Univ, Grad Sch Pharmaceut Sci, Dept Mol Hlth Sci, Nagoya, Aichi 4678603, Japan.
EM hhayashi@phar.nagoya-cu.ac.jp; aroysato@mail.ecc.u-tokyo.acjp
OI Takahashi, Yu/0000-0003-3186-2925
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NR 36
TC 101
Z9 117
U1 0
U2 9
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0022-2275
EI 1539-7262
J9 J LIPID RES
JI J. Lipid Res.
PD APR
PY 2008
VL 49
IS 4
BP 880
EP 892
DI 10.1194/jlr.M700545-JLR200
PG 13
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 280IV
UT WOS:000254420800018
PM 18187772
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Prakash, R
   Mintz, JD
   Stepp, DW
AF Prakash, Rajan
   Mintz, James D.
   Stepp, David W.
TI Impact of obesity on coronary microvascular function in the Zucker rat
SO MICROCIRCULATION
LA English
DT Article
DE cardiac output; endothelin; microcirculation; nitric oxide
ID NITRIC-OXIDE FUNCTION; VASCULAR REACTIVITY; METABOLIC SYNDROME;
   INSULIN-RESISTANCE; HYPERTENSIVE-RATS; CARDIAC MYOCYTES; INDUCED
   INCREASE; IN-VITRO; ARTERIES; STRESS
AB Objective: To test the hypothesis that vasomotor control is impaired in the coronary circulation of prediabetic obese (OZR) relative to lean Zucker rats (LZR).
   Methods: Cardiac function was assessed with in vivo measures of cardiac output and microvascular structure and function was assessed in vitro using videomicroscopic techniques.
   Results: OZR showed a marked hyperdynamic circulation with an increased cardiac output and elevated stroke volume. Contrary to the stated hypothesis, the authors found no diminution of vasodilator function and no augmentation of vasoconstriction. Indeed, dilation to acetylcholine was potentiated and vasoconstriction to endothelin was reduced in OZR compared to LZR. Structural characteristics of small coronary arteries were similar between LZR and OZR.
   Conclusions: Taken together, these results indicate that obesity, as manifested in the prediabetic OZR, does not impair coronary vasomotor control. This lack of dysfunction in the presence of the same risk factors that affect other beds may reflect a reversal of vascular injury by the increased metabolism and coronary blood flow caused by hyperdynamic cardiac function early in obesity.
C1 Med Coll Georgia, Vasc Biol Ctr, Augusta, GA 30912 USA.
C3 University System of Georgia; Augusta University
RP Stepp, DW (corresponding author), Med Coll Georgia, Vasc Biol Ctr, 1459 Laney Walker Blvd, Augusta, GA 30912 USA.
EM dstepp@mail.mcg.edu
RI Stepp, David/F-4250-2011
FU NHLBI NIH HHS [HL 76533, HL-67303] Funding Source: Medline
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NR 34
TC 26
Z9 30
U1 0
U2 1
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA
SN 1073-9688
J9 MICROCIRCULATION
JI Microcirculation
PD JUL-AUG
PY 2006
VL 13
IS 5
BP 389
EP 396
DI 10.1080/10739680600745919
PG 8
WC Hematology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Hematology; Cardiovascular System & Cardiology
GA 060PF
UT WOS:000238813400004
PM 16815824
DA 2025-06-11
ER

PT J
AU Ganesan, SM
   Vazana, S
   Stuhr, S
AF Ganesan, Sukirth M.
   Vazana, Stephanie
   Stuhr, Sandra
TI Waistline to the gumline: Relationship between obesity and periodontal
   disease-biological and management considerations
SO PERIODONTOLOGY 2000
LA English
DT Review
DE dental setting; obesity; oral health; periodontal disease; practice
   management; risk
ID BODY-MASS INDEX; HUMAN GUT MICROBIOME; ADIPOSE-TISSUE; SUBGINGIVAL
   MICROBIOME; METABOLIC SYNDROME; FAT DISTRIBUTION; SALIVARY-GLANDS;
   VENOUS ACCESS; ASSOCIATION; HEALTH
AB Obesity is a pandemic and periodontitis is the sixth most prevalent disease in the world. These two noncommunicable diseases share several risk determinants. Epidemiologic evidence from the last 2 decades has established an increase in periodontitis prevalence in obese and overweight individuals. Biologic mechanisms potentially linking obesity and periodontal disease are adiposity-associated hyperinflammation, microbial dysbiosis, altered immune response, specific genetic polymorphisms, and increased stress. However, because of the lack of longitudinal interventional studies and randomized clinical trials, there is insufficient evidence to determine the cause-effect relationship between these two diseases. Despite this, the negative impact of obesity on oral health is well established. Several logistic and physiologic complications are associated with treating obese patients in a dental setting, and it requires an interprofessional team approach. Oral health care professionals need to be aware of the specific management considerations while rendering for this cohort, including modified practice facility and equipment, tailored supportive periodontal therapy, and heightened precaution during conscious sedation and surgical procedures.
C1 [Ganesan, Sukirth M.; Vazana, Stephanie; Stuhr, Sandra] Univ Iowa, Coll Dent & Dent Clin, Dept Periodont, Iowa City, IA USA.
C3 University of Iowa
RP Ganesan, SM (corresponding author), Dent Sci Bldg S448, Iowa City, IA 52242 USA.
EM sukirth-ganesan@uiowa.edu
RI Stuhr, Sandra/AAU-8274-2020
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NR 152
TC 23
Z9 26
U1 0
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0906-6713
EI 1600-0757
J9 PERIODONTOL 2000
JI Periodontol. 2000
PD OCT
PY 2021
VL 87
IS 1
BP 299
EP 314
DI 10.1111/prd.12390
PG 16
WC Dentistry, Oral Surgery & Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dentistry, Oral Surgery & Medicine
GA UK2BO
UT WOS:000691780100022
PM 34463987
DA 2025-06-11
ER

PT J
AU Ahluwalia, A
   Misto, A
   Vozzi, F
   Magliaro, C
   Mattei, G
   Marescotti, MC
   Avogaro, A
   Iori, E
AF Ahluwalia, Arti
   Misto, Alessandra
   Vozzi, Federico
   Magliaro, Chiara
   Mattei, Giorgio
   Marescotti, Maria Cristina
   Avogaro, Angelo
   Iori, Elisabetta
TI Systemic and vascular inflammation in an in-vitro model of central
   obesity
SO PLOS ONE
LA English
DT Article
ID FREE FATTY-ACIDS; ADIPOSE-TISSUE; METABOLIC SYNDROME; ENDOTHELIAL
   DYSFUNCTION; INSULIN-RESISTANCE; LACTATE PRODUCTION; LIPID-METABOLISM;
   GLUCOSE; CELL; DIFFERENTIATION
AB Metabolic disorders due to over-nutrition are a major global health problem, often associated with obesity and related morbidities. Obesity is peculiar to humans, as it is associated with lifestyle and diet, and so difficult to reproduce in animal models. Here we describe a model of human central adiposity based on a 3-tissue system consisting of a series of interconnected fluidic modules. Given the causal link between obesity and systemic inflammation, we focused primarily on pro-inflammatory markers, examining the similarities and differences between the 3-tissue model and evidence from human studies in the literature. When challenged with high levels of adiposity, the in-vitro system manifests cardiovascular stress through expression of E-selectin and von Willebrand factor as well as systemic inflammation (expressing IL-6 and MCP-1) as observed in humans. Interestingly, most of the responses are dependent on the synergic interaction between adiposity and the presence of multiple tissue types. The set-up has the potential to reduce animal experiments in obesity research and may help unravel specific cellular mechanisms which underlie tissue response to nutritional overload.
C1 [Ahluwalia, Arti; Magliaro, Chiara; Mattei, Giorgio] Univ Pisa, Res Ctr E Piaggio, Pisa, Italy.
   [Misto, Alessandra; Vozzi, Federico] Italian Natl Council Res, Inst Clin Physiol, Pisa, Italy.
   [Marescotti, Maria Cristina; Avogaro, Angelo; Iori, Elisabetta] Univ Padua, Dept Med, Padua, Italy.
C3 University of Pisa; Consiglio Nazionale delle Ricerche (CNR); University
   of Padua
RP Ahluwalia, A (corresponding author), Univ Pisa, Res Ctr E Piaggio, Pisa, Italy.
EM arti.ahluwalia@unipi.it
RI Magliaro, Chiara/AGJ-0790-2022; Avogaro, Angelo/S-3808-2016; Vozzi,
   Federico/C-9706-2014
OI Mattei, Giorgio/0000-0003-0441-9653; Vozzi,
   Federico/0000-0001-5457-2328; AVOGARO, ANGELO/0000-0002-1177-0516;
   Ahluwalia, Arti/0000-0001-5370-6750
FU European Union Seventh Framework Programme [304961]
FX The work leading to these results has received funding from the European
   Union Seventh Framework Programme (FP7/2007-2013) under grant agreement
   304961 (ReLiver). The funders had no role in study design, data
   collection and analysis, decision to publish, or preparation of the
   manuscript.
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NR 55
TC 22
Z9 23
U1 0
U2 1
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD FEB 13
PY 2018
VL 13
IS 2
AR e0192824
DI 10.1371/journal.pone.0192824
PG 15
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA FW1TV
UT WOS:000425083400058
PM 29438401
OA Green Submitted, gold, Green Published
DA 2025-06-11
ER

PT J
AU Rauf, A
   Imran, M
   Suleria, HAR
   Ahmad, B
   Peters, DG
   Mubarak, MS
AF Rauf, Abdur
   Imran, Muhammad
   Suleria, Hafiz Ansar Rasul
   Ahmad, Bashir
   Peters, Dennis G.
   Mubarak, Mohammad S.
TI A comprehensive review of the health perspectives of resveratrol
SO FOOD & FUNCTION
LA English
DT Review
ID INDUCED ENDOTHELIAL DYSFUNCTION; RENAL INTERSTITIAL FIBROSIS; CELL
   LUNG-CANCER; TF/J MOUSE MODEL; OXIDATIVE STRESS; DNA-DAMAGE; RAT MODEL;
   COGNITIVE IMPAIRMENT; DIABETIC-NEPHROPATHY; INFLAMMATORY MARKERS
AB Many natural products present in our diet, including flavonoids, can prevent the progression of cancer and other diseases. Resveratrol, a natural polyphenol present in various fruits and vegetables, plays an important role as a therapeutic and chemopreventive agent used in the treatment of various illnesses. It exhibits effects against different types of cancer through different pathways. It additionally exerts antidiabetic, anti-inflammatory, and anti-oxidant effects in a variety of cell types. Furthermore, the cardiovascular protective capacities of resveratrol are associated with multiple molecular targets and may lead to the development of novel therapeutic strategies for atherosclerosis, ischemia/reperfusion,metabolic syndrome, and heart failure. Accordingly, this article presents an overview of recent developments in the use of resveratrol for the prevention and treatment of different diseases along with various mechanisms. In addition, the present review summarizes the most recent literature pertaining to resveratrol as a chemotherapeutic agent against multiple diseases and provides an assessment of the potential of this natural compound as a complementary or alternative medicine.
C1 [Rauf, Abdur] Univ Swabi, Dept Chem, Anbar 23561, Khyber Pakhtunk, Pakistan.
   [Imran, Muhammad] Imperial Coll Business Studies, Dept Diet & Nutr Sci, Lahore, Pakistan.
   [Suleria, Hafiz Ansar Rasul] Univ Queensland, UQ Diamantina Inst, Translat Res Inst, Fac Med, 37 Kent St Woolloongabba, Brisbane, Qld 4072, Australia.
   [Suleria, Hafiz Ansar Rasul] Kansas State Univ, Dept Food Nutr Dietet & Hlth, Manhattan, KS 66506 USA.
   [Ahmad, Bashir] Univ Peshawar, Ctr Biotechnol & Microbiol, Peshawar 25120, Kpk, Pakistan.
   [Peters, Dennis G.] Indiana Univ, Dept Chem, Bloomington, IN 47405 USA.
   [Mubarak, Mohammad S.] Univ Jordan, Dept Chem, Amman 11942, Jordan.
C3 University of Queensland; Kansas State University; University of
   Peshawar; Indiana University System; Indiana University Bloomington;
   University of Jordan
RP Rauf, A (corresponding author), Univ Swabi, Dept Chem, Anbar 23561, Khyber Pakhtunk, Pakistan.; Mubarak, MS (corresponding author), Univ Jordan, Dept Chem, Amman 11942, Jordan.
EM mashaljcs@yahoo.com; mmubarak@ju.edu.jo
RI Suleria, Hafiz Ansar Rasul/D-3385-2013; ahmad, bashir/I-6884-2015;
   Imran, Muhammad/JEF-6364-2023; Mubarak, Mohammad/D-4182-2015; Rauf,
   Abdur/G-3304-2013
OI Rauf, Dr. Abdur/0000-0003-2429-5491; Mubarak,
   Mohammad/0000-0002-9782-0835; Suleria, Hafiz Ansar
   Rasul/0000-0002-2450-0830
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NR 151
TC 226
Z9 242
U1 7
U2 140
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PD DEC
PY 2017
VL 8
IS 12
BP 4284
EP 4305
DI 10.1039/c7fo01300k
PG 22
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA FQ1SC
UT WOS:000418136900001
PM 29044265
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Kaisaki, PJ
   Otto, GW
   McGouran, JF
   Toubal, A
   Argoud, K
   Waller-Evans, H
   Finlay, C
   Caldérari, S
   Bihoreau, MT
   Kessler, BM
   Gauguier, D
   Mott, R
AF Kaisaki, Pamela J.
   Otto, Georg W.
   McGouran, Joanna F.
   Toubal, Amine
   Argoud, Karene
   Waller-Evans, Helen
   Finlay, Clare
   Calderari, Sophie
   Bihoreau, Marie-Therese
   Kessler, Benedikt M.
   Gauguier, Dominique
   Mott, Richard
TI Genetic Control of Differential Acetylation in Diabetic Rats
SO PLOS ONE
LA English
DT Article
ID LIVER-MITOCHONDRIA; RODENT MODEL; SIRT3; STRESS; DEACETYLASE; ACETYLOME;
   LONGEVITY; INSIGHTS
AB Post-translational protein modifications such as acetylation have significant regulatory roles in metabolic processes, but their relationship to both variation in gene expression and DNA sequence is unclear. We address this question in the Goto-Kakizaki (GK) rat inbred strain, a model of polygenic type 2 diabetes. Expression of the NAD-dependent deacetylase Sirtuin-3 is down-regulated in GK rats compared to normoglycemic Brown Norway (BN) rats. We show first that a promoter SNP causes down-regulation of Sirtuin-3 expression in GK rats. We then use mass-spectrometry to identify proteome-wide differential lysine acetylation of putative Sirtuin-3 protein targets in livers of GK and BN rats. These include many proteins in pathways connected to diabetes and metabolic syndrome. We finally sequence GK and BN liver transcriptomes and find that mRNA expression of these targets does not differ significantly between GK and BN rats, in contrast to other components of the same pathways. We conclude that physiological differences between GK and BN rats are mediated by a combination of differential protein acetylation and gene transcription and that genetic variation can modulate acetylation independently of expression.
C1 [Kaisaki, Pamela J.; Otto, Georg W.; Argoud, Karene; Waller-Evans, Helen; Finlay, Clare; Mott, Richard] Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.
   [McGouran, Joanna F.; Kessler, Benedikt M.] Univ Oxford, Nuffield Dept Med, Target Discovery Inst, Oxford, England.
   [Toubal, Amine; Calderari, Sophie; Gauguier, Dominique] INSERM, Cordeliers Res Ctr, U872, Paris, France.
   [Toubal, Amine; Calderari, Sophie; Gauguier, Dominique] Univ Paris 06, ICAN, Pitie Salpetriere Hosp, Inst Cardiometab & Nutr, Paris, France.
   [Bihoreau, Marie-Therese] Natl Genotyping Ctr, Evry, France.
C3 University of Oxford; Wellcome Centre for Human Genetics; University of
   Oxford; Universite Paris Cite; Sorbonne Universite; Institut National de
   la Sante et de la Recherche Medicale (Inserm); Assistance Publique
   Hopitaux Paris (APHP); Hopital Universitaire Pitie-Salpetriere - APHP;
   Institut National de la Sante et de la Recherche Medicale (Inserm);
   Sorbonne Universite
RP Mott, R (corresponding author), Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.
EM richard.mott@well.ox.ac.uk
RI Kessler, Benedikt/JGC-6978-2023; McGouran, Joanna/A-1545-2019; Gauguier,
   Dominique/G-2190-2016
OI Kessler, Benedikt/0000-0002-8160-2446; Calderari,
   Sophie/0000-0002-9669-681X; McGouran, Joanna/0000-0002-9349-2141; Mott,
   Richard/0000-0002-1022-9330; Otto, Georg W/0000-0002-3929-948X;
   Waller-Evans, Helen/0000-0003-4133-6064; Gauguier,
   Dominique/0000-0001-6156-9530
FU Wellcome Trust [083573/Z/07/Z, 057733, 075491/Z/04, 090532/Z/09/Z]; MRC
   Hub grant [G0900747 91070]; European Community [HEALTH-F4-2010-241504];
   Agence Nationale pour la Recherche [ANR-08-GENOPAT-030]; Fondation pour
   la Recherche Medicale (FRM) [INE20091217993]; Institute of
   Cardiometabolism and Nutrition (ICAN) [ANR-10-IAHU-05]; Biomedical
   Research Centre (NIHR) Oxford; John Fell OUP award; Wellcome Trust
   [083573/Z/07/Z] Funding Source: Wellcome Trust
FX This work was supported by a Wellcome Trust grant to RM (083573/Z/07/Z),
   a Wellcome Trust Senior Fellowship in Basic Biomedical Science (057733)
   to DG, a Wellcome Trust Core Award Grant (075491/Z/04), Wellcome Trust
   grant reference 090532/Z/09/Z, MRC Hub grant G0900747 91070, a grant
   from the European Community's Seventh Framework Programmes under the
   grant agreement HEALTH-F4-2010-241504 (EURATRANS), the Agence Nationale
   pour la Recherche (ANR-08-GENOPAT-030), the Fondation pour la Recherche
   Medicale (FRM, INE20091217993) and the Institute of Cardiometabolism and
   Nutrition (ICAN, ANR-10-IAHU-05). BMK is supported by the Biomedical
   Research Centre (NIHR) Oxford and a John Fell OUP award. The funders had
   no role in study design, data collection and analysis, decision to
   publish, or preparation of the manuscript.
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NR 43
TC 4
Z9 4
U1 0
U2 18
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD APR 17
PY 2014
VL 9
IS 4
AR e94555
DI 10.1371/journal.pone.0094555
PG 11
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA AG3IK
UT WOS:000335309100034
PM 24743600
OA Green Accepted, Green Submitted, gold, Green Published
DA 2025-06-11
ER

PT J
AU Krishnan, E
   Sokolove, J
AF Krishnan, Eswar
   Sokolove, Jeremy
TI Uric acid in heart disease: a new C-reactive protein?
SO CURRENT OPINION IN RHEUMATOLOGY
LA English
DT Review
DE cardiovascular; hyperuricemia; risk; uric acid
ID INTIMA-MEDIA THICKNESS; CARDIOVASCULAR-DISEASE; MYOCARDIAL-INFARCTION;
   ENDOTHELIAL FUNCTION; METABOLIC SYNDROME; OXIDATIVE STRESS;
   BLOOD-PRESSURE; ALLOPURINOL; RISK; ATHEROSCLEROSIS
AB Purpose of review
   To review and interpret the recently published data on hyperuricemia and cardiovascular disease to present an opinion on the nature of link between serum uric acid concentration and the risk for cardiovascular outcomes, and to comment on its implications for clinical practice.
   Recent findings
   Evidence has accumulated in prospective observational studies that link hyperuricemia among younger adults with the risk of subsequent hypertension. Such associations have been observed with respect to insulin resistance, diabetes, and other cardiovascular risk factors. Newer data confirm the link between hyperuricemia and cardiovascular mortality. The use of allopurinol has been shown to be associated with reduced mortality risk in longer term observational studies and with reduced blood pressure in short-term randomized controlled trials. None of these findings is confounded by traditional risk factors.
   Summary
   The available evidence has established a link between hyperuricemia and cardiovascular disease and this may be causal. Without waiting for the resolution of causality arguments, one can start using serum uric acid concentration as an inexpensive cardiovascular risk marker.
C1 [Krishnan, Eswar; Sokolove, Jeremy] Stanford Univ, Sch Med, Stanford, CA 94305 USA.
C3 Stanford University
RP Krishnan, E (corresponding author), 1000 Welch Rd,Suite 203, Palo Alto, CA 94304 USA.
EM E.krishnan@stanford.edu
RI krishnan, Eswar/AAY-1269-2020
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NR 37
TC 26
Z9 29
U1 0
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1040-8711
J9 CURR OPIN RHEUMATOL
JI Curr. Opin. Rheumatol.
PD MAR
PY 2011
VL 23
IS 2
BP 174
EP 177
DI 10.1097/BOR.0b013e3283432dd3
PG 4
WC Rheumatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Rheumatology
GA 715JB
UT WOS:000286879200009
PM 21178630
DA 2025-06-11
ER

PT J
AU Park, HJ
   Rhie, SJ
   Shim, I
AF Park, Hyun Jung
   Rhie, Sung Ja
   Shim, Insop
TI The effects of physical exercise therapy on weight control: its
   regulation of adipocyte physiology and metabolic capacity
SO JOURNAL OF EXERCISE REHABILITATION
LA English
DT Review
DE Cardiovascular diseases; Obesity; Physical exercise; Meta-bolic
   mechanism
ID BODY-MASS INDEX; BREAST-CANCER RISK; PSYCHIATRIC-DISORDERS; ADIPONECTIN
   LEVELS; OBESITY; LEPTIN; HEALTH; ASSOCIATION; MECHANISMS; SEX
AB Factors associated with increased body mass, including dyslipidemia, hypertension, insulin resistance, vascular endothelial dysfunction and sleep disorders, may contribute to the exacerbation of cardiovascular disease. These health problems associated with obesity are caused by accumulated metabolism and physical and emotional stress. Lifestyle, especially exercise, is a major therapeutic strategy for the treatment and management of obesity-induced metabolic problems. Metabolic disease often co-occurs with abdominal obesity. Exercise is necessary for the treatment of obesity, diabetes and cardiovascular disease. A po-tential benefit of exercise is to promote fat burning and energy use in- creases both during exercise itself and in the post-exercise period. Ex-ercise suppresses basal metabolic rate and also has many health ben-efits. Why should we exercise to lose weight? Does physical activity help lower blood pressure, blood cholesterol, and blood sugar? In this article, we review the positive effects of physical exercise on weight maintenance and weight loss, and the effectiveness of physical exer-cise on the treatment and prevention of metabolic syndrome.
C1 [Park, Hyun Jung] Kyonggi Univ, Dept Food Sci & Biotechnol, Suwon, South Korea.
   [Rhie, Sung Ja] Halla Univ, Dept Beauty Design, Wonju, South Korea.
   [Shim, Insop] Kyung Hee Univ, Coll Med, Dept Physiol, Seoul, South Korea.
   [Shim, Insop] Kyung Hee Univ, Coll Med, Dept Physiol, 26 Kyungheeedae ro, Seoul 02447, South Korea.
   [Park, Hyun Jung] Kyonggi Univ, Dept Food Sci & Biotechnol, 154-42 Gwanggyosan ro, Suwon 16227, South Korea.
C3 Kyonggi University; Kyung Hee University; Kyung Hee University; Kyonggi
   University
RP Shim, I (corresponding author), Kyung Hee Univ, Coll Med, Dept Physiol, 26 Kyungheeedae ro, Seoul 02447, South Korea.; Park, HJ (corresponding author), Kyonggi Univ, Dept Food Sci & Biotechnol, 154-42 Gwanggyosan ro, Suwon 16227, South Korea.
EM phj1116@kyonggi.ac.kr; ishim@khu.ac.kr
OI Shim, Insop/0000-0002-8014-9782
FU National Research Foundation of Korea [NRF2021R1A2C1093825]; World-home
   doctor Co.
FX This research was supported by National Research Foundation of Korea
   (NRF2021R1A2C1093825) and World-home doctor Co. (2022) .
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NR 68
TC 5
Z9 6
U1 2
U2 21
PU KOREAN SOC EXERCISE REHABILITATION
PI SEOUL
PA 264 BAEKJEGOBUN-RO, SONGPA-GU, SEOUL, 138-841, SOUTH KOREA
SN 2288-176X
EI 2288-1778
J9 J EXERC REHABIL
JI J. Exerc. Rehabil.
PD JUN
PY 2023
VL 19
IS 3
BP 141
EP 148
DI 10.12965/jer.2346232.116
PG 8
WC Rehabilitation
WE Emerging Sources Citation Index (ESCI)
SC Rehabilitation
GA M9VZ8
UT WOS:001033631100002
PM 37435589
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Graus-Nunes, F
   Souza-Mello, V
AF Graus-Nunes, Francielle
   Souza-Mello, Vanessa
TI The renin-angiotensin system as a target to solve the riddle of
   endocrine pancreas homeostasis
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Review
DE Pancreas; Islet; Local renin-angiotensin system; GSIS; AT1R
ID CONVERTING ENZYME 2; STIMULATED INSULIN-SECRETION; BETA-CELL
   DYSFUNCTION; HIGH-FAT DIET; MOUSE MODEL; METABOLIC SYNDROME; RESISTANCE;
   INHIBITION; BLOCKADE; ISLETS
AB Local renin-angiotensin system (RAS) in the pancreas is linked to the modulation of glucose-stimulated insulin secretion (GSIS) in beta cells and insulin sensitivity in target tissues, emerging as a promising tool in the prevention and/or treatment of obesity, diabetes, and systemic arterial hypertension. Insulin resistance alters pancreatic islet cell distribution and morphology and hypertrophied islets exhibit upregulated angiotensin II type 1 receptor, which drives oxidative stress, apoptosis, and fibrosis, configuring beta cell dysfunction and diminishing islet lifespan. Pharmacological modulation of RAS has shown beneficial effects in diet-induced obesity model, mainly related to the translational potential that angiotensin receptor blockers and ECA2/ANG (1-7)/MAS receptor axis modulation have when it comes to islet preservation and type 2 diabetes prevention and/or treatment. This review describes the existing evidence for different approaches to blocking RAS elements in the management of insulin resistance and diabetes and focuses on islet remodeling and GSIS in rodents and humans.
C1 [Graus-Nunes, Francielle; Souza-Mello, Vanessa] Univ Estado Rio De Janeiro, Inst Biol, Biomed Ctr, Lab Morphometry Metab & Cardiovasc Dis, Av 28 Setembro 87 Fds, BR-20551030 Rio De Janeiro, RJ, Brazil.
C3 Universidade do Estado do Rio de Janeiro
RP Souza-Mello, V (corresponding author), Univ Estado Rio De Janeiro, Inst Biol, Biomed Ctr, Lab Morphometry Metab & Cardiovasc Dis, Av 28 Setembro 87 Fds, BR-20551030 Rio De Janeiro, RJ, Brazil.
EM souzamello.uerj@gmail.com
RI Souza-Mello, Vanessa/E-3463-2014
OI Souza-Mello, Vanessa/0000-0002-2510-9569
FU Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior - Brasil
   (CAPES) [001]
FX This study was financed in part by the Coordenacao de Aperfeicoamento de
   Pessoal de Nivel Superior - Brasil (CAPES) - Finance Code 001. The
   authors declare no conflict of interest.
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NR 73
TC 28
Z9 30
U1 0
U2 11
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD JAN
PY 2019
VL 109
BP 639
EP 645
DI 10.1016/j.biopha.2018.10.191
PG 7
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA HD5AE
UT WOS:000452539100072
PM 30404071
OA gold
DA 2025-06-11
ER

PT J
AU Jadeja, RN
   Thounaojam, MC
   Singh, TB
   Devkar, RV
   Ramachandran, AV
AF Jadeja, Ravirajsinh N.
   Thounaojam, Menaka C.
   Singh, Thouchom Brojendro
   Devkar, Ranjitsinh V.
   Ramachandran, A. V.
TI Traditional uses, phytochemistry and pharmacology of Clerodendron
   glandulosum Coleb - a review
SO ASIAN PACIFIC JOURNAL OF TROPICAL MEDICINE
LA English
DT Review
DE Clerodendron glandulosum. Coleb; Hypertension; Hyperlipidemia; Insulin
   resistance; Obesity; Atherosclerosis
ID HIGH-FAT DIET; METABOLIC SYNDROME; NONALCOHOLIC STEATOHEPATITIS;
   LIVER-DISEASE; EXTRACT; ATHEROSCLEROSIS; VERBENACEAE; CHALLENGES;
   MODELS; ISSUES
AB Present review for the first time provides a complete botanical description and information on ethnomedicinal uses of Clerodendron glandulosum.Coleb (CG: Fam, Verbenaceae). Recent studies conducted from our laboratory provide pharmacological evidence for its anti-hypertensive, anti-diabetic and anti-obesity potentials. Further, its beneficial potential in preventing in vitro and in vivo non-alcoholic steatohepatitis and atherosclerosis and potent hepatoprotective and free radical scavenging abilities along with its acute and sub-chronic toxicological evaluations are also reported from our laboratory. In keeping with its traditional uses. CG extract was capable of ameliorating experimentally induced hypertension, diabetes and obesity. Its beneficial potential against NASH induced oxidative stress and atherosclerosis can be attributed to its potent free radical scavenging potential. Non-toxic nature of CG leaf extract further provides added merit to its reported pharmacological properties. The present review summarizes the pioneering scientific evidence for the pharmacological effects of CG against related metabolic disorders like hypertension, diabetes and obesity along with anti oxidant potential and beneficial effects against non alcoholic steatohepatitis.
C1 [Jadeja, Ravirajsinh N.; Thounaojam, Menaka C.; Devkar, Ranjitsinh V.; Ramachandran, A. V.] Maharaja Sayajirao Univ Baroda, Fac Sci, Div Phytotherapeut & Metab Endocrinol, Dept Zool, Vadodara 390002, Gujarat, India.
   [Singh, Thouchom Brojendro] Oriental Coll, Dept Chem, Imphal 795001, Manipur, India.
C3 Maharaja Sayajirao University Baroda
RP Devkar, RV (corresponding author), Maharaja Sayajirao Univ Baroda, Fac Sci, Div Phytotherapeut & Metab Endocrinol, Dept Zool, Vadodara 390002, Gujarat, India.
EM phyto_met@yahoo.com
RI Jadeja, Ravirajsinh/G-3116-2011; Thounaojam, Menaka/AAO-5842-2020
OI Thounaojam, menaka/0000-0002-3422-2053; Jadeja,
   Ravirajsinh/0000-0002-1712-454X; A. V., Ramachandran/0000-0002-2326-0994
FU Council of Scientific and Industrial Research (CSIR), New Delhi, INDIA
   [09/114/(0179)/2011/EMR-1]
FX Mr. Ravirajsinh N Jadeja wish to acknowledge Council of Scientific and
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NR 51
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Z9 20
U1 0
U2 4
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1995-7645
J9 ASIAN PAC J TROP MED
JI Asian Pac. J. Trop. Med.
PD JAN
PY 2012
VL 5
IS 1
BP 1
EP 6
DI 10.1016/S1995-7645(11)60236-8
PG 6
WC Public, Environmental & Occupational Health; Tropical Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health; Tropical Medicine
GA 878NU
UT WOS:000299264600001
PM 22182635
OA gold
DA 2025-06-11
ER

PT J
AU Affourtit, C
   Jastroch, M
   Brand, MD
AF Affourtit, Charles
   Jastroch, Martin
   Brand, Martin D.
TI Uncoupling protein-2 attenuates glucose-stimulated insulin, secretion in
   INS-1E insulinoma cells by lowering mitochondrial reactive oxygen
   species
SO FREE RADICAL BIOLOGY AND MEDICINE
LA English
DT Article
DE Pancreatic beta cells; Glucose-stimulated insulin secretion; Uncoupling
   protein 2; Mitochondrial respiration; Reactive oxygen species; Coupling
   efficiency of oxidative phosphorylation; Type 2 diabetes; Metabolic
   syndrome; Free radicals
ID PANCREATIC BETA-CELLS; PROTON LEAK; UCP2; DYSFUNCTION; EXPRESSION;
   CAPACITY; NEURONS
AB Glucose-stimulated insulin secretion (GSIS) by pancreatic beta cells is regulated by mitochondrial uncoupling protein-2 (UCP2), but opposing phenotypes, GSIS improvement and impairment, have been reported for different Ucp2-ablated mouse models. By measuring mitochondrial bioenergetics in attached INS-1E insulinoma cells with and without UCP2, we show that UCP2 contributes to proton leak and attenuates glucose-induced rises in both respiratory activity and the coupling efficiency of oxidative phosphorylation. Strikingly, the GSIS improvement seen upon UCP2 knockdown in INS-1E cells is annulled completely by the cell-permeative antioxidant MnTMPyP. Consistent with this observation. UCP2 lowers mitochondrial reactive oxygen species at high glucose levels. We conclude that UCP2 plays both regulatory and protective roles in beta cells by acutely lowering GSIS and chronically preventing oxidative stress. Our findings thus provide a mechanistic explanation for the apparently discrepant findings in the field. (C) 2010 Elsevier Inc. All rights reserved.
C1 [Affourtit, Charles; Brand, Martin D.] MRC, Mitochondria Biol Unit, Cambridge CB2 0XY, England.
   [Affourtit, Charles; Jastroch, Martin; Brand, Martin D.] Buck Inst Res Aging, Novato, CA 94945 USA.
C3 Buck Institute for Research on Aging
RP Affourtit, C (corresponding author), Univ Plymouth, Sch Biomed & Biol Sci, Portland Sq Bldg, Plymouth PL4 8AA, Devon, England.
EM charles.affourtit@plymouth.ac.uk
RI Affourtit, Charles/I-3958-2019; Jastroch, Martin/I-7494-2017; Brand,
   Martin/A-9423-2012
OI Brand, Martin/0000-0003-4418-6153; Affourtit,
   Charles/0000-0003-1776-9943
FU Medical Research Council; National Institutes of Health [P01 AG025901,
   PL1 AG032118, P30 AG025708, R01 AG033542]; W.M. Keck Foundation; Ellison
   Medical Foundation [AG-SS-2288-09]; Deutsche Forschungsgemeinschaft [JA
   1884/2-1]
FX This work was supported by the Medical Research Council, UK (C. A. and
   M.D.B.), and the National Institutes of Health (P01 AG025901, PL1
   AG032118, P30 AG025708, and R01 AG033542), the W.M. Keck Foundation, The
   Ellison Medical Foundation (AG-SS-2288-09) (M.D. B.), and the Deutsche
   Forschungsgemeinschaft (JA 1884/2-1) (M.J.). C. A. and M.D.B. are
   consultants to Seahorse Bioscience. We thank Drs. Pierre Maechler and
   Claes Wollheim (Department of Internal Medicine, University Medical
   Center, Geneva, Switzerland) for the kind donation of INS-1E cells.
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NR 35
TC 68
Z9 77
U1 0
U2 3
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0891-5849
EI 1873-4596
J9 FREE RADICAL BIO MED
JI Free Radic. Biol. Med.
PD MAR 1
PY 2011
VL 50
IS 5
BP 609
EP 616
DI 10.1016/j.freeradbiomed.2010.12.020
PG 8
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 719BQ
UT WOS:000287174700007
PM 21172424
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Schnabl, B
AF Schnabl, Bernd
TI Peroxisome Proliferator-Activated Receptor-δ as Emerging Target in Liver
   Disease
SO DRUG DEVELOPMENT RESEARCH
LA English
DT Article
DE PPAR delta; hepatic steatosis; hepatic steatohepatitis; metabolic
   syndrome; liver fibrosis; chronic liver disease
ID CHRONIC HEPATITIS-C; PPAR-DELTA; ANTIFIBROTIC AGENTS; OXIDATIVE STRESS;
   AGONIST; THERAPY; GROWTH; BETA; STEATOHEPATITIS; METABOLISM
AB Liver fibrosis is characterized by an excessive deposition of extracellular matrix (ECM) proteins that occurs in chronic liver disease of any origin, including nonalcoholic steatohepatitis (NASH), alcohol abuse, and viral hepatitis. Cirrhosis occurs with the development of regenerating nodules of hepatocytes and is a major health burden worldwide. Patients with decompensated liver cirrhosis have a poor prognosis, with liver transplantation often being necessary. The current treatment paradigm for patients with hepatic fibrosis is to treat the underlying liver disease. However, if this cannot be achieved, there are currently no effective antifibrotic treatments for patients with chronic liver diseases. With the advent of basic molecular technology providing insight into the mechanisms of the development of hepatic fibrosis, there is now an opportunity to develop therapeutic interventions for human clinical use. In this review, the function of peroxisome proliferator-activated receptor-delta (PPAR delta) will be summarized with a special emphasis on ligand activation as potential use in liver disease. Drug Dev Res 71:106-111, 2010. (C) 2009 Wiley-Liss, Inc.
C1 Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA.
C3 University of California System; University of California San Diego
RP Schnabl, B (corresponding author), Univ Calif San Diego, Dept Med, MC0702,9500 Gilman Dr, La Jolla, CA 92093 USA.
EM beschnabl@ucsd.edu
RI Schnabl, Bernd/HCH-3471-2022
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NR 44
TC 1
Z9 1
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0272-4391
EI 1098-2299
J9 DRUG DEVELOP RES
JI Drug Dev. Res.
PD APR
PY 2010
VL 71
IS 2
BP 106
EP 111
DI 10.1002/ddr.20358
PG 6
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 591TO
UT WOS:000277327600002
OA Bronze
DA 2025-06-11
ER

PT J
AU Ishay, Y
   Kolben, Y
   Kessler, A
   Ilan, Y
AF Ishay, Yuval
   Kolben, Yotam
   Kessler, Asa
   Ilan, Yaron
TI Role of circadian rhythm and autonomic nervous system in liver function:
   a hypothetical basis for improving the management of hepatic
   encephalopathy
SO AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
LA English
DT Review
DE chronotherapy; circadian rhythm; digital system; encephalopathy; hepatic
   encephalopathy
ID RANDOMIZED CONTROLLED-TRIAL; FATTY LIVER; NONALCOHOLIC STEATOHEPATITIS;
   METABOLIC SYNDROME; CLOCK GENES; LONG-TERM; INFLAMMATORY RESPONSE;
   RIFAXIMIN TREATMENT; INSULIN-RESISTANCE; OXIDATIVE STRESS
AB Hepatic encephalopathy (HE) is a common, incapacitating complication of cirrhosis that affects many patients with cirrhosis. Although several therapies have proven effective in the treatment and prevention of this condition, several patients continue to suffer from covert disease or episodes of relapse. The circadian rhythm has been demonstrated to be pivotal for many body functions, including those of the liver. Here, we explore the impact of circadian rhythm-dependent signaling on the liver and discuss the evidence of its impact on liver pathology and metabolism. We describe the various pathways through which circadian influences are mediated. Finally, we introduce a novel method for improving patient response to drugs aimed at treating HE by utilizing the circadian rhythm. A digital system that introduces a customization-based technique for improving the response to therapies is presented as a hypothetical approach for improving the effectiveness of current medications used for the treatment of recurrent and persistent hepatic encephalopathy.
C1 [Ishay, Yuval; Kolben, Yotam; Kessler, Asa; Ilan, Yaron] Hebrew Univ Jerusalem, Fac Med, Hadassah Med Ctr, Dept Med, Jerusalem, Israel.
C3 Hebrew University of Jerusalem; Hadassah University Hospital; Hadassah
   University Medical Center
RP Ilan, Y (corresponding author), Hebrew Univ Jerusalem, Fac Med, Hadassah Med Ctr, Dept Med, Jerusalem, Israel.
EM ilan@hadassah.org.il
OI Ilan, Yaron/0000-0003-0802-1220
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NR 208
TC 28
Z9 28
U1 0
U2 7
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0193-1857
EI 1522-1547
J9 AM J PHYSIOL-GASTR L
JI Am. J. Physiol.-Gastroint. Liver Physiol.
PD OCT
PY 2021
VL 321
IS 4
BP G400
EP G412
DI 10.1152/ajpgi.00186.2021
PG 13
WC Gastroenterology & Hepatology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Physiology
GA UY8OH
UT WOS:000701776200005
PM 34346773
DA 2025-06-11
ER

PT J
AU Iqbal, WA
   Mendes, I
   Finney, K
   Oxley, A
   Lietz, G
AF Iqbal, Wasim A.
   Mendes, Ines
   Finney, Kieran
   Oxley, Anthony
   Lietz, Georg
TI Reduced plasma carotenoids in individuals suffering from metabolic
   diseases with disturbances in lipid metabolism: a systematic review and
   meta-analysis of observational studies
SO INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION
LA English
DT Review
DE Non-communicable disease; metabolic diseases; carotenoids
ID BODY-MASS INDEX; OXIDATIVE STRESS; ANTIOXIDANT STATUS; LOWER PREVALENCE;
   NUTRIENT INTAKE; US ADULTS; SERUM; OBESITY; ASSOCIATION; RETINOL
AB This review summarises the association between serum carotenoids, serum retinoids and dietary intake outcomes with obesity/overweight and individuals with metabolic diseases with disturbances in lipid metabolism. Observational studies reporting dietary intakes and serum concentrations of carotenoids and retinol were collected from Medline and Web of Science. Mean differences were calculated between "cases" (classified as obese, overweight or having a metabolic disease with disturbances in lipid metabolism; i.e. non-alcoholic fatty liver disease, type 2 diabetes, dyslipidaemia or metabolic syndrome) and "comparator group" (classified as normal weight healthy individuals) and summarised in meta-analyses. Significant summary measures were observed for most serum provitamin A and non-provitamin A carotenoids. Studies reporting total serum carotenoids had shown the greatest decrease (-0.28 mu mol/l [-0.33, -0.23], p<.001, I (2)=62.5%, n = 7). There were no significant summary measures for dietary outcomes, suggesting a physiological role of low serum carotenoids in the development of obesity and associated diseases.
C1 [Iqbal, Wasim A.] Newcastle Univ, Sch Nat & Environm Sci, Plant & Microbe Grp, Newcastle Upon Tyne, Tyne & Wear, England.
   [Mendes, Ines] Divino Espirito Santo Hosp, Endocrinol & Nutr Serv, Ponta Delgada, Portugal.
   [Finney, Kieran; Oxley, Anthony; Lietz, Georg] Newcastle Univ, Populat Hlth Sci Inst, Human Nutr Res Ctr, Newcastle Upon Tyne, Tyne & Wear, England.
C3 Newcastle University - UK; Newcastle University - UK
RP Iqbal, WA (corresponding author), Newcastle Univ, Sch Nat & Environm Sci, Plant & Microbe Grp, Newcastle Upon Tyne, Tyne & Wear, England.; Lietz, G (corresponding author), Newcastle Univ, Populat Hlth Sci Inst, Human Nutr Res Ctr, Newcastle Upon Tyne, Tyne & Wear, England.
EM w.iqbal@ncl.ac.uk; georg.lietz@ncl.ac.uk
RI Lietz, Georg/A-4084-2012; Oxley, Anthony/GYE-0700-2022
OI Lietz, Georg/0000-0002-2103-0335; Oxley, Anthony/0000-0002-5311-8016;
   Mendes, Ines/0000-0001-7956-288X
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NR 83
TC 7
Z9 8
U1 0
U2 3
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0963-7486
EI 1465-3478
J9 INT J FOOD SCI NUTR
JI Int. J. Food Sci. Nutr.
PD OCT 3
PY 2021
VL 72
IS 7
BP 879
EP 891
DI 10.1080/09637486.2021.1882962
EA FEB 2021
PG 13
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA WG7DZ
UT WOS:000617974600001
PM 33586569
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Fang, ZJ
   Pyne, S
   Pyne, NJ
AF Fang, Zijian
   Pyne, Susan
   Pyne, Nigel J.
TI Ceramide and sphingosine 1-phosphate in adipose dysfunction
SO PROGRESS IN LIPID RESEARCH
LA English
DT Review
ID INDUCED INSULIN-RESISTANCE; ENDOPLASMIC-RETICULUM STRESS; NOVO
   SPHINGOLIPID BIOSYNTHESIS; INDUCED INFLAMMATORY RESPONSE; ADIPOCYTE
   PRECURSOR CELLS; FREE FATTY-ACIDS; SKELETAL-MUSCLE; KINASE 1;
   PLASMA-MEMBRANE; DIHYDROCERAMIDE DESATURASE
AB The increased adipose tissue mass of obese individuals enhances the risk of metabolic syndrome, type 2 diabetes and cardiovascular diseases. During pathological expansion of adipose tissue, multiple molecular controls of lipid storage, adipocyte turn-over and endocrine secretion are perturbed and abnormal lipid metabolism results in a distinct lipid profile. There is a role for ceramides and sphingosine 1-phosphate (S1P) in inducing adipose dysfunction. For instance, the alteration of ceramide biosynthesis, through the de-regulation of key enzymes, results in aberrant formation of ceramides (e.g. C-16:0 and C-18:0) which block insulin signaling and promote adipose inflammation. Furthermore, SIP can induce defective adipose tissue phenotypes by promoting chronic inflammation and inhibiting adipogenesis. These abnormal changes are discussed in the context of possible therapeutic approaches to re-establish normal adipose function and to, thereby, increase insulin sensitivity in type 2 diabetes. Such novel approaches include blockade of ceramide biosynthesis using inhibitors of sphingomyelinase or dihydroceramide desaturase and by antagonism of S1P receptors, such as S1P(2).
C1 [Fang, Zijian; Pyne, Susan; Pyne, Nigel J.] Univ Strathclyde, Strathclyde Inst Pharm & Biomed Sci, 161 Cathedral St, Glasgow G4 0RE, Lanark, Scotland.
C3 University of Strathclyde
RP Pyne, NJ (corresponding author), Univ Strathclyde, Strathclyde Inst Pharm & Biomed Sci, 161 Cathedral St, Glasgow G4 0RE, Lanark, Scotland.
EM n.j.pyne@strath.ac.uk
RI Pyne, Susan/AAF-5001-2019
OI Pyne, Susan/0000-0002-6608-9584
FU China Pharmaceutical University; Undergraduate International Exchange
   fund
FX Zijian Fang would like thank the China Pharmaceutical University for a
   Scholarship from the Undergraduate International Exchange fund.
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NR 227
TC 33
Z9 40
U1 0
U2 23
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0163-7827
EI 1873-2194
J9 PROG LIPID RES
JI Prog. Lipid Res.
PD APR
PY 2019
VL 74
BP 145
EP 159
DI 10.1016/j.plipres.2019.04.001
PG 15
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA HX6KC
UT WOS:000467511500008
PM 30951736
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Shoji, H
   Shimizu, T
AF Shoji, Hiromichi
   Shimizu, Toshiaki
TI Effect of human breast milk on biological metabolism in infants
SO PEDIATRICS INTERNATIONAL
LA English
DT Review
DE human breast milk; metabolic syndrome; metabolomics; oxidative stress;
   prostaglandin
ID CARDIOVASCULAR RISK-FACTORS; INDUCED OXIDATIVE DAMAGE; PROSTAGLANDIN
   D-2; TERM INFANTS; COGNITIVE-DEVELOPMENT; URINARY METABOLITE;
   ARACHIDONIC-ACID; BLOOD-PRESSURE; LIPID PROFILE; TETRANOR-PGDM
AB The metabolic changes that occur during the postnatal weaning period appear to be particularly important for future health, and human breast milk is considered to provide the optimal source of nutrition for infants. Our previous studies examined the effect of feeding type on antioxidative properties, glucose and insulin metabolism, the lipid profile, metabolomics, and prostaglandin (PG) metabolism in term and preterm infants. A urinary marker of oxidative DNA damage (8-hydroxy-2 '-deoxyguanosine) was significantly lower in breast-fed term and preterm infants than in formula-fed infants. Markers of insulin sensitivity were significantly lower and atherosclerotic indices were significantly higher in breast-fed preterm infants than in mixed-fed infants at discharge. On urinary metabolomics analysis, choline, choline metabolites, and lactic acid were significantly lower in breast-fed term infants than in formula-fed infants. Urinary PGD(2) metabolite level in breast-fed term infants was also significantly lower than in formula-fed term infants. This indicates that human breast milk affects biological metabolism in early infancy.
C1 [Shoji, Hiromichi; Shimizu, Toshiaki] Juntendo Univ, Dept Pediat & Adolescent Med, Grad Sch Med, Tokyo, Japan.
C3 Juntendo University
RP Shoji, H (corresponding author), Juntendo Univ, Dept Pediat & Adolescent Med, Grad Sch Med, Bunkyo Ku, 2-1-1 Hongo, Tokyo 1138421, Japan.
EM hshoji@juntendo.ac.jp
RI Shoji, Hiromichi/ABB-5653-2021
FU JSPS KAKENHI [16790592, 22791039, 15K09727]; Grants-in-Aid for
   Scientific Research [16790592, 15K09727, 22791039] Funding Source: KAKEN
FX We are grateful to Dr Satoshi Oguchi (Oguchi Children's Clinic) for his
   suggestion of oxidative stress research, and to Dr Yoshiki Miura
   (Laboratory of Proteomics and Biomolecular Science, Research Support
   Center, Juntendo University Graduate School of Medicine) and Dr Takehiko
   Yokomizo (Department of Biochemistry, Juntendo University School of
   Medicine) for their technical support and helpful suggestions. This
   review was supported by JSPS KAKENHI (grant numbers 16790592, 22791039,
   and 15K09727). We thank Ellen Knapp, PhD, from Edanz Group
   (www.edanzediting.com/ac) for editing a draft of this manuscript.
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NR 56
TC 26
Z9 30
U1 1
U2 26
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1328-8067
EI 1442-200X
J9 PEDIATR INT
JI Pediatr. Int.
PD JAN
PY 2019
VL 61
IS 1
BP 6
EP 15
DI 10.1111/ped.13693
PG 10
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA HK9TY
UT WOS:000458336000004
PM 30194786
DA 2025-06-11
ER

PT J
AU Yang, R
   Li, XL
   Yang, XH
   Zheng, XH
AF Yang, Rui
   Li, Xianli
   Yang, Xiaohong
   Zheng, Xiaohui
TI The pro-inflammatory effect of uric acid in human umbilical vein
   endothelial cells via ROS-PI3K/AKT-NF-κB signal pathway
SO INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
LA English
DT Article
DE Uric acid; tumor necrosis factors-alpha; inflammatory; atherosclerosis
ID C-REACTIVE PROTEIN; NF-KAPPA-B; TNF-ALPHA; OXIDATIVE STRESS;
   CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; DYSFUNCTION;
   ATHEROSCLEROSIS; EXPRESSION; MARKERS
AB Inflammation plays an important role in the pathological process of many cardiovascular diseases specially atherosclerosis. As a biomarker of inflammatory Tumor necrosis factor-alpha (TNF-alpha) plays a key role in the process of atherogenesis. In this research we investigated the pro-inflammatory effect of uric acid in human umbilical vein endothelial cells. Our research indicated that uric acid was able to induce TNF-alpha expression in HUVECs. Antioxidant NAC abolished uric acid-induced TNF-alpha expression. In addition, uric acid stimulated generation of reactive oxygen species (ROS) and activated AKT phosphorylation. The further study confirmed that PI3K/AKT inhibitor LY294002 and NF-kappa B inhibitor pyrrolidine dithiocarbamate both abolished uric acid induced TNF-alpha expression. In conclusion, uric acid is able to induce TNF-alpha expression via PI3K/AKT-NF-kappa B signal pathway in HUVECs, which provides a new evidence for the pro-inflammatory and pro-atherosclerotic effects of uric acid.
C1 [Yang, Rui; Li, Xianli; Yang, Xiaohong; Zheng, Xiaohui] Anyang Dist Hosp, Dept Cardiovasc, Puyang, Henan, Peoples R China.
RP Zheng, XH (corresponding author), Anyang Dist Hosp, Dept Cardiovasc, Puyang, Henan, Peoples R China.
EM zhengxiaohui41@163.com
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NR 34
TC 0
Z9 0
U1 1
U2 10
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 1940-5901
J9 INT J CLIN EXP MED
JI Int. J. Clin. Exp. Med.
PY 2019
VL 12
IS 1
BP 549
EP 556
PG 8
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA HJ5FA
UT WOS:000457202700056
DA 2025-06-11
ER

PT J
AU Veloso, AGB
   Lima, NEA
   Ornelas, ED
   Cardoso, CG
   Marques, MR
   Reis, BDAA
   Fonseca, FLA
   Maifrino, LBM
AF Bexiga Veloso, Aparecida Gabriela
   Alves Lima, Nathalia Edviges
   Ornelas, Elisabete de Marco
   Cardoso, Clever Gomes
   Marques, Mara Rubia
   Aguiar Alves Reis, Beatriz da Costa
   Affonso Fonseca, Fernando Luiz
   Mesiano Maifrino, Laura Beatriz
TI Effects of moderate exercise on biochemical, morphological, and
   physiological parameters of the pancreas of female mice with estrogen
   deprivation and dyslipidemia
SO MEDICAL MOLECULAR MORPHOLOGY
LA English
DT Article
DE Dyslipidemia; Pancreas; Physical exercise; Menopause; Estrogen
   deprivation
ID IMPAIRED GLUCOSE-TOLERANCE; BETA-CELL FUNCTION; FATTY-ACID; INSULIN
   SENSITIVITY; WAIST CIRCUMFERENCE; METABOLIC SYNDROME; SERUM-LIPIDS;
   MENOPAUSE; TYPE-2; STRESS
AB Menopausal women are at high risk of developing heart disease. However, physical exercise practice can reverse this scenario. We evaluated the biochemical, morphological, and physiological effects of moderate aerobic physical exercise on the pancreas of knockout mice for LDL receptor with estrogen deprivation by ovariectomy. Animals were divided into six groups (n = 5): sedentary non-ovariectomized control; sedentary ovariectomized control; trained ovariectomized control; sedentary non-ovariectomized LDL-R knockout; sedentary ovariectomized LDL-R knockout; and trained ovariectomized LDL-R knockout. Physical exercise practice promoted improvement in biometric and biochemical parameters analyzed, with reduction of visceral adipose tissue and VLDL, triglycerides, total cholesterol, and blood glucose levels. In addition, physical exercise practice altered the morphology of pancreatic islets and improved their response to the effects of menopause. Thus, physical exercise practice was fundamental to minimize the effects of dyslipidemia associated with ovariectomy in the pancreatic tissue of LDL-R knockout animals, contributing to reduce the risk of developing cardiac diseases in the menopause period.
C1 [Bexiga Veloso, Aparecida Gabriela; Alves Lima, Nathalia Edviges; Ornelas, Elisabete de Marco; Mesiano Maifrino, Laura Beatriz] Univ Sao Judas Tadeu, Lab Estudos Morfoquantitat & Imunohistoquim, R Taquari 546, BR-03166000 Sao Paulo, SP, Brazil.
   [Cardoso, Clever Gomes; Marques, Mara Rubia] Univ Fed Goias, Ave Esperanca S-N, BR-74690900 Goiania, Go, Brazil.
   [Aguiar Alves Reis, Beatriz da Costa; Affonso Fonseca, Fernando Luiz] Fac Med ABC, Lab Anal Clin, Ave Principe Gales 821, BR-09060650 Santo Andre, SP, Brazil.
   [Affonso Fonseca, Fernando Luiz] Univ Fed Sao Paulo, Dept Ciencias Farmaceut, R Prof Artur Riedel 275, BR-09972270 Diadema, SP, Brazil.
C3 Universidade Sao Judas Tadeu; Universidade Federal de Goias; Faculdade
   de Medicina do ABC; Universidade Federal de Sao Paulo (UNIFESP)
RP Maifrino, LBM (corresponding author), Univ Sao Judas Tadeu, Lab Estudos Morfoquantitat & Imunohistoquim, R Taquari 546, BR-03166000 Sao Paulo, SP, Brazil.
EM lmaifrino@uol.com.br
RI Lima, Nathalia/D-2790-2015; Gomes Cardoso, Clever/M-7206-2018; Alves,
   Beatriz/F-2311-2014; Maifrino, Laura Beatriz Mesiano/E-6769-2012
OI Gomes Cardoso, Clever/0000-0002-9175-7695; Alves,
   Beatriz/0000-0001-9930-7747; Maifrino, Laura Beatriz
   Mesiano/0000-0002-9456-192X
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NR 45
TC 6
Z9 6
U1 0
U2 1
PU SPRINGER JAPAN KK
PI TOKYO
PA CHIYODA FIRST BLDG EAST, 3-8-1 NISHI-KANDA, CHIYODA-KU, TOKYO, 101-0065,
   JAPAN
SN 1860-1480
EI 1860-1499
J9 MED MOL MORPHOL
JI Med. Mol. Morphol.
PD JUN
PY 2018
VL 51
IS 2
BP 118
EP 127
DI 10.1007/s00795-018-0179-x
PG 10
WC Biology; Microscopy; Pathology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics; Microscopy; Pathology
GA GG5DB
UT WOS:000432714400007
PM 29335884
DA 2025-06-11
ER

PT J
AU Paradkar, PH
   Mishra, LS
   Joshi, J
   Dandekar, SP
   Vaidya, RA
   Vaidya, AB
AF Paradkar, P. H.
   Mishra, L. S.
   Joshi, J., V
   Dandekar, S. P.
   Vaidya, R. A.
   Vaidya, A. B.
TI In vitro macrophage activation: A technique for screening
   anti-inflammatory, immunomodulatory and anticancer activity of
   phytomolecules
SO INDIAN JOURNAL OF EXPERIMENTAL BIOLOGY
LA English
DT Review
DE Chemokines; Cytokines; Herbal; Homeostasis; Inflammation; Tumor
   associated macrophages (TAMs)
ID TUMOR-ASSOCIATED MACROPHAGES; NF-KAPPA-B; PERITONEAL-MACROPHAGES; M2
   MACROPHAGES; CELL-LINE; MODEL; IL-6; 2-METHOXYESTRADIOL; PLASTICITY;
   MONOCYTES
AB Macrophage activation plays a significant role in homeostasis of organisms. Various internal and external stress factors may affect their function, leading to adverse effects on the body. 'In vitro macrophage activation techniques provide us with a window to understand the mechanisms of inflammation and response of macrophages to the modulating interventions. Apart from infectious diseases, inflammation is also the major culprit in pathogenesis of many noncommunicable diseases such as arthritis, obesity, metabolic syndrome, diabetes, cancer, cardiovascular disease etc. In vitro macrophage activation allows us to study the role of polarized macrophages in the process of pathogenesis. This emerging technique leads to newer diagnostics, understanding pathophysiological mechanism/s, drug development and management of chronic inflammatory diseases. We, at MRC-KHS, use this technique for screening of medicinal plant-derived phytomolecules for their anti-inflammatory, immunomodulatory and anticancer activities. This review briefly outlines the different experimental models of in vitro macrophage activation and their applications for understanding the pathophysiological mechanisms of underlying chronic inflammation and screening of therapeutic activity of plant-based phytomolecules.
C1 [Paradkar, P. H.; Mishra, L. S.; Joshi, J., V; Vaidya, R. A.; Vaidya, A. B.] Kasturba Hlth Soc, Med Res Ctr, Vile Parle West, Bombay, Maharashtra, India.
   [Paradkar, P. H.; Dandekar, S. P.] Seth GS Med Coll, Bombay, Maharashtra, India.
   [Paradkar, P. H.; Dandekar, S. P.] King Edward Mem Hosp, Bombay, Maharashtra, India.
C3 Seth Gordhandas Sunderdas Medical College & King Edward Memorial
   Hospital; Seth Gordhandas Sunderdas Medical College & King Edward
   Memorial Hospital
RP Paradkar, PH (corresponding author), Kasturba Hlth Soc, Med Res Ctr, Vile Parle West, Bombay, Maharashtra, India.; Paradkar, PH (corresponding author), Seth GS Med Coll, Bombay, Maharashtra, India.; Paradkar, PH (corresponding author), King Edward Mem Hosp, Bombay, Maharashtra, India.
RI MISHRA, LAXMI/HOC-5278-2023
OI MISHRA, LAXMI/0000-0002-7212-3785
CR [Anonymous], CLIN DEV IMMUNOL
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NR 60
TC 11
Z9 11
U1 0
U2 6
PU NATL INST SCIENCE COMMUNICATION-NISCAIR
PI NEW DELHI
PA DR K S KRISHNAN MARG, PUSA CAMPUS, NEW DELHI 110 012, INDIA
SN 0019-5189
EI 0975-1009
J9 INDIAN J EXP BIOL
JI Indian J. Exp. Biol.
PD MAR
PY 2017
VL 55
IS 3
BP 133
EP 141
PG 9
WC Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics
GA EN2OK
UT WOS:000395849600001
PM 30184414
DA 2025-06-11
ER

PT J
AU Baños, G
   Medina-Campos, ON
   Maldonado, PD
   Zamora, J
   Pérez, I
   Pavón, N
   Pedraza-Chaverrí, J
AF Baños, G
   Medina-Campos, ON
   Maldonado, PD
   Zamora, J
   Pérez, I
   Pavón, N
   Pedraza-Chaverrí, J
TI Activities of antioxidant enzymes in two stages of pathology development
   in sucrose-fed rats
SO CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
LA English
DT Article
DE antioxidant enzymes; gender influence; hypertriglyceridemia;
   hypertension; sucrose-fed rats
ID CORONARY-ARTERY-DISEASE; SUPEROXIDE-DISMUTASE; METABOLIC SYNDROME;
   OXIDATIVE STRESS; GLUTATHIONE-PEROXIDASE; LIPID-PEROXIDATION;
   HEART-DISEASE; FREE-RADICALS; EXPRESSION; CATALASE
AB The activities of catalase in liver, heart and kidney as well as glutathione peroxidase and superoxide dismutase in liver, heart, kidney, and serum from hypertriglyceridemic and hypertensive female and male rats were measured at 3 and 8 months of daily administration of sucrose in their drinking water. This treatment induces high levels of serum triglycerides, central obesity, moderate hypertension, hyperinsulinemia, and an increase in lipoper oxida tion, among other alterations. The experimental periods were chosen on the basis of previous observations: at 3 months the level of serum triglycerides increases significantly above the normal value and remains without major changes thereafter, but the blood pressure only rises significantly at about 4 months in males and 5 months in females. So, at 8 months the rats have been subjected to abnormal conditions for 3-4 months. The effect of these and the influence of sex on levels of antioxidant enzymes were investigated. Both factors, sucrose treatment and sex, were conducive to significant changes in those variables.
C1 INCICh, Dept Bioquim, Mexico City 14080, DF, Mexico.
   Univ Nacl Autonoma Mexico, Dept Endocrinol, Mexico City, DF, Mexico.
   Univ Nacl Autonoma Mexico, Inst Nacl Cardiol Ignacio Chavez, Dept Patol, Mexico City, DF, Mexico.
   Univ Nacl Autonoma Mexico, Fac Quim, Mexico City, DF, Mexico.
C3 Universidad Nacional Autonoma de Mexico; National Institute of
   Cardiology - Mexico; Universidad Nacional Autonoma de Mexico;
   Universidad Nacional Autonoma de Mexico
RP INCICh, Dept Bioquim, Juan Badiano 1, Mexico City 14080, DF, Mexico.
EM gbanos@yahoo.com
RI Maldonado, Perla/AAW-8417-2020
OI Pavon, Natalia/0000-0002-8520-5077; Maldonado, Perla
   D/0000-0002-7629-0580
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NR 56
TC 10
Z9 10
U1 0
U2 2
PU CANADIAN SCIENCE PUBLISHING
PI OTTAWA
PA 65 AURIGA DR, SUITE 203, OTTAWA, ON K2E 7W6, CANADA
SN 0008-4212
EI 1205-7541
J9 CAN J PHYSIOL PHARM
JI Can. J. Physiol. Pharmacol.
PD MAR
PY 2005
VL 83
IS 3
BP 278
EP 286
DI 10.1139/Y05-013
PG 9
WC Pharmacology & Pharmacy; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Physiology
GA 930KC
UT WOS:000229413700006
PM 15870842
DA 2025-06-11
ER

PT J
AU Ryan, AS
   Serra, MC
   Bigman, G
   Jaber, S
AF Ryan, Alice S.
   Serra, Monica C.
   Bigman, Galya
   Jaber, Sausan
TI The Effects of Weight Loss and Aerobic Exercise on Cortisol and Cortisol
   Suppression in Postmenopausal Women with Overweight and Obesity
SO ENDOCRINE RESEARCH
LA English
DT Article
DE Aerobic exercise; cortisol; postmenopausal women; weight loss
ID METABOLIC SYNDROME; ABDOMINAL OBESITY; FAT DISTRIBUTION; FOOD CHOICE;
   LIFE-STYLE; STRESS; DIET; SENSITIVITY; INCREASES; LIPOLYSIS
AB Purpose: The goal of this study was to explore the complex relationship between obesity, dietary content, weight loss, and cortisol concentrations in postmenopausal women with overweight and obesity. Methods: Women completed basal cortisol testing, a dexamethasone suppression test (DST), DXA scan, 3-hour oral glucose tolerance test (OGTT), and food records before (n = 60) and a subset after 6-months of weight loss (WL; n = 15) or aerobic exercise training+weight loss (AEX+WL, n = 34). Results: At baseline, plasma cortisol concentrations decreased significantly after DST in the entire group, a 54% suppression which was associated with basal glucose. Basal glucose levels and glucose AUC from the OGTT are associated with basal cortisol levels (r = 0.44 and r = 0.29, p < 0.05 respectively). The intervention resulted in significant weight loss (-8%) but no significant changes in basal cortisol or changes in cortisol from basal to DST were observed. Conclusion: Additional research is necessary to better comprehend cortisol regulation in postmenopausal women particularly in response to effective weight reduction interventions.
C1 [Ryan, Alice S.] Univ Maryland, Dept Med, VA Res Serv, Div Gerontol Geriatr & Palliat Med,Sch Med, Baltimore, MD 21201 USA.
   [Ryan, Alice S.; Bigman, Galya; Jaber, Sausan] VA Maryland Hlth Care Syst, Baltimore VA Med Ctr Geriatr Res, Educ & Clin Ctr GRECC, Baltimore, MD 21201 USA.
   [Serra, Monica C.] UT Hlth San Antonio & San Antonio VA GRECC, Dept Med, Div Geriatr Gerontol & Palliat Med, San Antonio, TX USA.
   [Serra, Monica C.] UT Hlth San Antonio & San Antonio VA GRECC, Sam & Ann Barshop Inst Longev & Aging Studies, Dept Med, San Antonio, TX USA.
C3 University System of Maryland; University of Maryland Baltimore;
   Geriatric Research Education & Clinical Center
RP Ryan, AS (corresponding author), Univ Maryland, Dept Med, VA Res Serv, Div Gerontol Geriatr & Palliat Med,Sch Med, Baltimore, MD 21201 USA.; Ryan, AS (corresponding author), VA Maryland Hlth Care Syst, Baltimore VA Med Ctr Geriatr Res, Educ & Clin Ctr GRECC, Baltimore, MD 21201 USA.
EM aryan@som.umaryland.edu
RI Bigman, Galya/J-9072-2019; Jaber, Sausan/LMN-4893-2024
FU Senior Research Career Scientist Award [IK6 RX003977]; U.S. Department
   of Veterans Affairs Rehabilitation R&D Service (A.S.R.); VA Baltimore
   GRECC, National Institute on Aging awards [RO1-AG19310, R01 AG20116];
   Claude D. Pepper Older Americans Independence Center [P30-AG028747]
FX Funding includes support from a Senior Research Career Scientist Award
   IK6 RX003977 from the U.S. Department of Veterans Affairs Rehabilitation
   R&D Service (A.S.R.), and VA Baltimore GRECC, National Institute on
   Aging awards RO1-AG19310, R01 AG20116, and Claude D. Pepper Older
   Americans Independence Center P30-AG028747
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NR 47
TC 0
Z9 0
U1 0
U2 0
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 0743-5800
EI 1532-4206
J9 ENDOCR RES
JI Endocr. Res.
PD APR 3
PY 2025
VL 50
IS 2
BP 87
EP 95
DI 10.1080/07435800.2024.2439408
EA DEC 2024
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 2DE3W
UT WOS:001376857800001
PM 39665581
DA 2025-06-11
ER

PT J
AU Mollace, R
   Longo, S
   Nardin, M
   Tavernese, A
   Musolino, V
   Cardamone, A
   Federici, M
AF Mollace, Rocco
   Longo, Susanna
   Nardin, Matteo
   Tavernese, Annamaria
   Musolino, Vincenzo
   Cardamone, Antonio
   Federici, Massimo
TI Role of MASLD in CVD: A review of emerging treatment options
SO DIABETES RESEARCH AND CLINICAL PRACTICE
LA English
DT Article
DE MASLD; Cardiovascular disease; Insulin resistance; Diabetes
ID FATTY LIVER-DISEASE; NONALCOHOLIC STEATOHEPATITIS; CARDIOVASCULAR
   EVENTS; GLUCOSE-METABOLISM; PRACTICE GUIDANCE; CONTROLLED-TRIAL;
   MANAGEMENT; EZETIMIBE; EFFICACY; SAFETY
AB Metabolic dysfunction-associated steatotic liver disease (MASLD), represents a growing health concern due to its strong association with metabolic syndrome, obesity, and type 2 diabetes mellitus (T2DM). This condition, characterized by excessive fat accumulation in the liver not attributed to alcohol consumption, has emerged as a leading cause of chronic liver disease globally. MASLD significantly elevates the risk of major adverse cardiovascular events (MACE) through mechanisms like increased oxidative stress, insulin resistance, and chronic inflammation, all of which contribute to the development of atherosclerosis and endothelial dysfunction. Effective management of MASLD is crucial not only for liver health but also for cardiovascular disease (CVD) prevention. Lifestyle modifications, particularly weight loss achieved through dietary changes and increased physical activity, are the cornerstone of MASLD treatment. Additionally, pharmacological interventions, especially antihyperglycemic agents, play a pivotal role in treating MASLD in patients with T2DM. Novel therapeutic agents targeting various pathways of metabolic and liver dysfunction are under investigation, offering hope for more effective management strategies. This review explores the interconnectedness of MASLD and CVD, highlighting current and emerging therapeutic approaches.
C1 [Mollace, Rocco] Tor Vergata Univ, Dept Expt Med, I-00133 Rome, Italy.
   [Mollace, Rocco] Humanitas Gavazzeni, Cardiol Unit, I-24125 Bergamo, Italy.
   [Longo, Susanna; Federici, Massimo] Policlin Tor Vergata Univ Hosp, Ctr Atherosclerosis, Internal Med Unit, Via Oxford 81, I-00133 Rome, Italy.
   [Longo, Susanna; Federici, Massimo] Univ Roma Tor Vergata, Dept Syst Med, I-00133 Rome, Italy.
   [Nardin, Matteo] Humanitas Univ, Dept Biomed Sci, Via Rita Levi Montalcini 4, I-20090 Milan, Italy.
   [Nardin, Matteo] ASST Spedali Civili Brescia, Dept Med, Internal Med, I-25123 Brescia, Italy.
   [Tavernese, Annamaria] IRCCS San Raffaele Sci Inst, Cardiovasc Imaging Unit, Cardiothorac Vasc Dept, Milan, Italy.
   [Musolino, Vincenzo; Cardamone, Antonio] Magna Graecia Univ Catanzaro, IRC FSH Ctr, Dept Hlth Sci, I-88100 Germaneto, Catanzaro, Italy.
C3 University of Rome Tor Vergata; Istituto Clinico Humanitas Gavazzeni;
   University of Rome Tor Vergata; Policlin Tor Vergata; University of Rome
   Tor Vergata; Humanitas University; Hospital Spedali Civili Brescia;
   Vita-Salute San Raffaele University; IRCCS Ospedale San Raffaele; Magna
   Graecia University of Catanzaro
RP Federici, M (corresponding author), Univ Roma Tor Vergata, Dept Med Syst, Via Cracovia 50, I-00133 Rome, Italy.
EM federicm@uniroma2.it
RI Musolino, Vincenzo/AAD-2678-2019; Mollace, Rocco/ABH-5643-2020;
   Cardamone, Antonio/HGA-5612-2022; Nardin, Matteo/AAI-9457-2021;
   Federici, Massimo/G-9940-2012
OI Musolino, Vincenzo/0000-0002-4763-2211
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NR 74
TC 2
Z9 2
U1 3
U2 6
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0168-8227
EI 1872-8227
J9 DIABETES RES CLIN PR
JI Diabetes Res. Clin. Pract.
PD NOV
PY 2024
VL 217
AR 111891
DI 10.1016/j.diabres.2024.111891
EA OCT 2024
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA J8E7Y
UT WOS:001339344600001
PM 39414088
OA hybrid
DA 2025-06-11
ER

PT J
AU Niu, MY
   Li, L
   Su, ZL
   Wei, LL
   Pu, WY
   Zhao, C
   Ding, YB
   Wazir, J
   Cao, WS
   Song, SY
   Gao, Q
   Wang, HW
AF Niu, Mengyuan
   Li, Li
   Su, Zhonglan
   Wei, Lulu
   Pu, Wenyuan
   Zhao, Chen
   Ding, Yibing
   Wazir, Junaid
   Cao, Wangsen
   Song, Shiyu
   Gao, Qian
   Wang, Hongwei
TI An integrative transcriptome study reveals Ddit4/Redd1 as a key
   regulator of cancer cachexia in rodent models
SO CELL DEATH & DISEASE
LA English
DT Article
ID UBIQUITIN LIGASE ATROGIN1/MAFBX; SKELETAL-MUSCLE; GENE-EXPRESSION; P38
   MAPK; PACKAGE; ATROPHY; STRESS; IDENTIFICATION; ATROGIN-1; HYPOXIA
AB Cancer cachexia is a multifactorial metabolic syndrome that causes up to 20% of cancer-related deaths. Muscle atrophy, the hallmark of cancer cachexia, strongly impairs the quality of life of cancer patients; however, the underlying pathological process is still poorly understood. Investigation of the disease pathogenesis largely relies on cachectic mouse models. In our study, the transcriptome of the cachectic gastrocnemius muscle in the C26 xenograft model was integrated and compared with that of 5 more different datasets. The bioinformatic analysis revealed pivotal gene ontology (GO) terms and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways of the disease, and the key genes were validated. Construction of the protein-protein interaction network and the comparison of pathways enriched in cancer cachexia with 5 other muscle atrophy models revealed Ddit4 (DNA damage-inducible transcript 4), as a key protein in cancer cachexia. The higher expression of Ddit4 in cachectic muscle was further validated in animal models and cachectic cancer patients. Further study revealed that p38 induced the expression of Ddit4, which in turn inhibited the mTOR pathway in atrophic cells.
C1 [Niu, Mengyuan; Li, Li; Wei, Lulu; Pu, Wenyuan; Zhao, Chen; Wazir, Junaid; Song, Shiyu; Wang, Hongwei] Nanjing Univ, Med Sch, State Key Lab Analyt Chem Life Sci, Nanjing, Peoples R China.
   [Niu, Mengyuan; Li, Li; Wei, Lulu; Pu, Wenyuan; Zhao, Chen; Ding, Yibing; Wazir, Junaid; Cao, Wangsen; Song, Shiyu; Gao, Qian; Wang, Hongwei] Nanjing Univ, Med Sch, Ctr Translat Med, Nanjing, Peoples R China.
   [Niu, Mengyuan; Li, Li; Wei, Lulu; Pu, Wenyuan; Zhao, Chen; Ding, Yibing; Wazir, Junaid; Cao, Wangsen; Song, Shiyu; Gao, Qian; Wang, Hongwei] Nanjing Univ, Med Sch, Jiangsu Key Lab Mol Med, Nanjing, Peoples R China.
   [Su, Zhonglan] Nanjing Med Univ, Affiliated Hosp 1, Dept Dermatol, Nanjing, Peoples R China.
C3 Nanjing University; Nanjing University; Nanjing University; Nanjing
   Medical University
RP Song, SY; Wang, HW (corresponding author), Nanjing Univ, Med Sch, State Key Lab Analyt Chem Life Sci, Nanjing, Peoples R China.; Song, SY; Gao, Q; Wang, HW (corresponding author), Nanjing Univ, Med Sch, Ctr Translat Med, Nanjing, Peoples R China.; Song, SY; Gao, Q; Wang, HW (corresponding author), Nanjing Univ, Med Sch, Jiangsu Key Lab Mol Med, Nanjing, Peoples R China.
EM songshiyu@nju.edu.cn; qian_gao@nju.edu.cn; hwang@nju.edu.cn
RI niu, mengyuan/KJL-4050-2024; Pu, Wenyuan/LKN-2563-2024; Song,
   Shiyu/AAO-5023-2021; Wazir, Junaid/ABF-1948-2020
OI Wazir, Junaid/0000-0001-9299-4716; Cao, Wangsen/0000-0001-6209-3482; Pu,
   Wenyuan/0000-0003-4955-4947
FU National Natural Science Foundation of China [82070912, 81773326];
   Fundamental Research Funds for the Central Universities [0214-14380509];
   Key Project of Research and Development of Ningxia Hui Autonomous Region
   of China [2017BN04]; Natural Science Foundation of Jiangsu Province
   China [BK20171347, BE2019676]; National Key R&D Program of China
   [2020YFC2005600, 2020YFC2005601, 2020YFC2005100, 2020YFC2005300]
FX This work was supported by grants from the National Natural Science
   Foundation of China (Nos. 82070912 and 81773326), The Fundamental
   Research Funds for the Central Universities (0214-14380509). The Key
   Project of Research and Development of Ningxia Hui Autonomous Region of
   China (No. 2017BN04), a grant from the Natural Science Foundation of
   Jiangsu Province China (No. BK20171347 and BE2019676) and grants from
   the National Key R&D Program of China (2020YFC2005600, 2020YFC2005601,
   2020YFC2005100, and 2020YFC2005300).
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NR 42
TC 20
Z9 21
U1 1
U2 15
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 2041-4889
J9 CELL DEATH DIS
JI Cell Death Dis.
PD JUN 26
PY 2021
VL 12
IS 7
AR 652
DI 10.1038/s41419-021-03932-0
PG 12
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA TC6HU
UT WOS:000668743100001
PM 34175899
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Sadeghi, A
   Rostamirad, A
   Seyyedebrahimi, S
   Meshkani, R
AF Sadeghi, Asie
   Rostamirad, Atefeh
   Seyyedebrahimi, Shadisadat
   Meshkani, Reza
TI Curcumin ameliorates palmitate-induced inflammation in skeletal muscle
   cells by regulating JNK/NF-kB pathway and ROS production
SO INFLAMMOPHARMACOLOGY
LA English
DT Article
DE Curcumin; Inflammation; Skeletal muscle cells; NF-kB; JNK; TNF-; IL-6;
   Reactive oxygen species
ID NF-KAPPA-B; INDUCED INSULIN-RESISTANCE; ATTENUATING OXIDATIVE STRESS;
   RANDOMIZED CONTROLLED-TRIAL; FATTY-ACIDS; KEY ROLE; ACTIVATION;
   MACROPHAGES; OXYGEN; SUPPRESSION
AB Curcumin, a natural polyphenol compound, has the beneficial effects on several diseases such as metabolic syndrome, cancer, and diabetes. The anti-inflammatory property of curcumin has been demonstrated in different cells; however, its role in prevention of palmitate-induced inflammation in skeletal muscle C2C12 cells is not known. In this study, we examined the effect of curcumin on the inflammatory responses stimulated by palmitate in C2C2 cells. The results showed that palmitate upregulated the mRNA expression and protein release of IL-6 and TNF- cytokines in C2C12 cells, while pretreatment with curcumin was able to attenuate the effect of palmitate on inflammatory cytokines. The anti-inflammatory effect of curcumin was associated with the repression of phosphorylation of IKK-IKK, and JNK. Palmitate also caused an increase in reactive oxygen species (ROS) level that curcumin abrogated it. Collectively, these findings suggest that curcumin may represent a promising therapy for prevention of inflammation in skeletal muscle cells.
C1 [Sadeghi, Asie] Kerman Univ Med Sci, Afzalipour Sch Med, Dept Biochem, Kerman, Iran.
   [Rostamirad, Atefeh] Tarbiat Modares Univ, Fac Med Sci, Dept Clin Biochem, Tehran, Iran.
   [Seyyedebrahimi, Shadisadat; Meshkani, Reza] Univ Tehran Med Sci, Fac Med, Dept Clin Biochem, Tehran, Iran.
   [Meshkani, Reza] Univ Tehran Med Sci, Fac Med, Dept Biochem, Tehran, Iran.
C3 Kerman University of Medical Sciences; Tarbiat Modares University;
   Tehran University of Medical Sciences; Tehran University of Medical
   Sciences
RP Meshkani, R (corresponding author), Univ Tehran Med Sci, Fac Med, Dept Clin Biochem, Tehran, Iran.; Meshkani, R (corresponding author), Univ Tehran Med Sci, Fac Med, Dept Biochem, Tehran, Iran.
EM rmeshkani@tums.ac.ir
RI Sadeghi, Asie/AAD-8519-2019
FU Deputy of Research, Tehran University of Medical Sciences
   [96-04-30-36707]
FX This work was financially supported by a Grant (96-04-30-36707) from the
   Deputy of Research, Tehran University of Medical Sciences.
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NR 39
TC 62
Z9 66
U1 2
U2 54
PU SPRINGER BASEL AG
PI BASEL
PA PICASSOPLATZ 4, BASEL, 4052, SWITZERLAND
SN 0925-4692
EI 1568-5608
J9 INFLAMMOPHARMACOLOGY
JI Inflammopharmacology
PD OCT
PY 2018
VL 26
IS 5
BP 1265
EP 1272
DI 10.1007/s10787-018-0466-0
PG 8
WC Immunology; Pharmacology & Pharmacy; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Pharmacology & Pharmacy; Toxicology
GA GU2IY
UT WOS:000445094000012
PM 29644554
DA 2025-06-11
ER

PT J
AU Wilhelm, C
   Masouleh, SK
   Kazakov, A
AF Wilhelm, Christoph
   Masouleh, Schekufe Kharabi
   Kazakov, Alexander
TI Metabolic Regulation of Innate Lymphoid Cell-Mediated Tissue
   Protection-Linking the Nutritional State to Barrier Immunity
SO FRONTIERS IN IMMUNOLOGY
LA English
DT Article
DE innate lymphoid cells; metabolic syndrome; allergic inflammation;
   immunometabolism; aryl hydrocarbon receptor; vitamin A; lipid mediators
ID ARYL-HYDROCARBON RECEPTOR; ALTERNATIVELY ACTIVATED MACROPHAGES;
   IFN-GAMMA PRODUCTION; ADIPOSE-TISSUE; RETINOIC ACID; T-CELLS; ADAPTIVE
   THERMOGENESIS; INTESTINAL IMMUNITY; BEIGE FAT; VITAMIN-A
AB Innate lymphoid cells (ILC) are a recently described group of tissue-resident immune cells that play essential roles in maintaining and protecting the tissue barrier against invading pathogens. Extensive research has revealed that ILC-mediated immune responses are controlled by dietary components and metabolites. An additional role of ILC as important direct regulators of host metabolism and glucose tolerance is emerging. This suggests that ILC may act as key dietary sensors integrating nutritional and metabolic stress to facilitate both maintenance of barrier sites and a coordinated immune response protecting these tissues. In this respect, investigations have begun to determine how different ILC responses are metabolically fueled and the impact of nutrient availability on the regulation of ILC function. Here, we discuss the current literature concerning dietary and metabolic control of ILC. In particular, we address whether the dietary and metabolic control of ILC and their simultaneous influence on host metabolism may function as a coordinated program of barrier defense.
C1 [Wilhelm, Christoph; Masouleh, Schekufe Kharabi; Kazakov, Alexander] Univ Bonn, Univ Hosp Bonn, Dept Clin Chem & Clin Pharmacol, Unit Immunopathol, Bonn, Germany.
C3 University of Bonn
RP Wilhelm, C (corresponding author), Univ Bonn, Univ Hosp Bonn, Dept Clin Chem & Clin Pharmacol, Unit Immunopathol, Bonn, Germany.
EM christoph.wilhelm@uni-bonn.de
RI Wilhelm, Christoph/ABE-7176-2020
OI Wilhelm, Christoph/0000-0002-9839-0291
FU NRW-Return programme of the Ministry for Science and Education of
   North-Rhine-Westfalia; Deutsche Forschungsgemeinschaft DFG [DFG
   (SPP1937)]
FX This work was supported by the NRW-Return programme of the Ministry for
   Science and Education of North-Rhine-Westfalia and the Deutsche
   Forschungsgemeinschaft DFG [program grant from the DFG (SPP1937)]. CW is
   a member of the DFG Excellence Cluster ImmunoSensation.
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NR 72
TC 29
Z9 31
U1 1
U2 10
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA PO BOX 110, EPFL INNOVATION PARK, BUILDING I, LAUSANNE, 1015,
   SWITZERLAND
SN 1664-3224
J9 FRONT IMMUNOL
JI Front. Immunol.
PD DEC 7
PY 2017
VL 8
AR 1742
DI 10.3389/fimmu.2017.01742
PG 8
WC Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology
GA FO9XP
UT WOS:000417252100001
PM 29375541
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Jung, SA
   Choi, M
   Kim, S
   Yu, R
   Park, T
AF Jung, Sung A.
   Choi, Miseon
   Kim, Sohee
   Yu, Rina
   Park, Taesun
TI Cinchonine Prevents High-Fat-Diet-Induced Obesity through Downregulation
   of Adipogenesis and Adipose Inflammation
SO PPAR RESEARCH
LA English
DT Article
ID BETA-CATENIN; METABOLIC SYNDROME; OXIDATIVE STRESS; INNATE IMMUNITY;
   CELL FACTOR; RESISTANCE; RECEPTORS; ADIPOCYTES; MODULATION; ACTIVATION
AB Cinchonine (C19H22N2O) is a natural compound of Cinchona bark. Although cinchonine's antiplatelet effect has been reported in the previous study, antiobesity effect of cinchonine has never been studied. The main objective of this study was to investigate whether cinchonine reduces high-fat-diet- (HFD-) induced adipogenesis and inflammation in the epididymal fat tissues of mice and to explore the underlying mechanisms involved in these reductions. HFD- fed mice treated with 0.05% dietary cinchonine for 10 weeks had reduced body weight gain (-38%), visceral fat-pad weights (-26%), and plasma levels of triglyceride, free fatty acids, total cholesterol, and glucose compared with mice fed with the HFD. Moreover, cinchonine significantly reversed HFD-induced downregulations of WNT10b and galanin-mediated signaling molecules and key adipogenic genes in the epididymal adipose tissues of mice. Cinchonine also attenuated the HFD- induced upregulation of proinflammatory cytokines by inhibiting toll-like-receptor-2- (TLR2-) and TLR4-mediated signaling cascades in the adipose tissue of mice. Our findings suggest that dietary cinchonine with its effects on adipogenesis and inflammation may have a potential benefit in preventing obesity.
C1 [Jung, Sung A.; Choi, Miseon; Kim, Sohee; Park, Taesun] Yonsei Univ, Dept Food & Nutr, Seoul 120749, South Korea.
   [Yu, Rina] Univ Ulsan, Dept Food Sci & Nutr, Ulsan 680749, South Korea.
C3 Yonsei University; University of Ulsan
RP Park, T (corresponding author), Yonsei Univ, Dept Food & Nutr, Seoul 120749, South Korea.
EM tspark@yonsei.ac.kr
OI Yu, Rina/0000-0002-1965-3891; Park, Taesun/0000-0002-9752-9407
FU Ministry of Health and Welfare, Republic of Korea [A110532]; Center for
   Food & Nutritional Genomics of the National Research Foundation (NRF) of
   Korea [2011-0000919]; Ministry of Education, Science and Technology
FX This research was supported by the Korea Health 21 R&D Project, Ministry
   of Health and Welfare, Republic of Korea (no. A110532), and by the SRC
   program (Center for Food & Nutritional Genomics: Grant no.,
   2011-0000919) of the National Research Foundation (NRF) of Korea funded
   by the Ministry of Education, Science and Technology.
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NR 39
TC 27
Z9 28
U1 0
U2 8
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1687-4757
EI 1687-4765
J9 PPAR RES
JI PPAR Res.
PY 2012
VL 2012
AR 541204
DI 10.1155/2012/541204
PG 11
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 955KX
UT WOS:000305019100001
PM 22675336
OA gold, Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Guilford, BL
   Ryals, JM
   Wright, DE
AF Guilford, B. L.
   Ryals, J. M.
   Wright, D. E.
TI Phenotypic Changes in Diabetic Neuropathy Induced by a High-Fat Diet in
   Diabetic C57Bl/6 Mice
SO EXPERIMENTAL DIABETES RESEARCH
LA English
DT Article
ID NERVE-CONDUCTION-VELOCITY; POLY(ADP-RIBOSE) POLYMERASE ACTIVATION;
   OXIDATIVE-NITROSATIVE STRESS; MUSCLE-SPINDLE INNERVATION; IMPAIRED
   GLUCOSE-TOLERANCE; INDUCED MOUSE MODEL; PERIPHERAL NEUROPATHY;
   NEUROTROPHIN TREATMENT; CUTANEOUS INNERVATION; METABOLIC SYNDROME
AB Emerging evidence suggests that dyslipidemia is an independent risk factor for diabetic neuropathy (DN) (reviewed by Vincent et al. 2009). To experimentally determine how dyslipidemia alters DN, we quantified neuropathic symptoms in diabetic mice fed a high-fat diet. Streptozotocin-induced diabetic C57BL/6 mice fed a high-fat diet developed dyslipidemia and a painful neuropathy (mechanical allodynia) instead of the insensate neuropathy (mechanical insensitivity) that normally develops in this strain. Nondiabetic mice fed a high-fat diet also developed dyslipidemia and mechanical allodynia. Thermal sensitivity was significantly reduced in diabetic compared to nondiabetic mice, but was not worsened by the high-fat diet. Moreover, diabetic mice fed a high-fat diet had significantly slower sensory and motor nerve conduction velocities compared to nondiabetic mice. Overall, dyslipidemia resulting from a high-fat diet may modify DN phenotypes and/or increase risk for developing DN. These results provide new insight as to how dyslipidemia may alter the development and phenotype of diabetic neuropathy.
C1 [Guilford, B. L.; Ryals, J. M.; Wright, D. E.] Univ Kansas, Med Ctr, Dept Anat & Cell Biol, Kansas City, KS 66160 USA.
C3 University of Kansas; University of Kansas Medical Center
RP Wright, DE (corresponding author), Univ Kansas, Med Ctr, Dept Anat & Cell Biol, Kansas City, KS 66160 USA.
EM dwright@kumc.edu
FU Eunice Kennedy Shriver National Institute of Child Health & Human
   Development [T32HD057850]; Juvenile Diabetes Research Foundation; NIH
   [RO1NS43314]; Kansas Intellectual and Developmental Disabilities
   Research Center [P30 NICHD HD 002528]; NIH from the Idea Network of
   Biomedical Research Excellence (INBRE) of the National Center for
   Research Resources [P20 RR016475, R01NS43313]
FX This paper was supported by Award no. T32HD057850 from the Eunice
   Kennedy Shriver National Institute of Child Health & Human Development
   (B. L. G.), the Juvenile Diabetes Research Foundation, and NIH
   RO1NS43314 (D. E. W). In addition, support was provided by the Kansas
   Intellectual and Developmental Disabilities Research Center P30 NICHD HD
   002528 and NIH Grant R01NS43313 and NIH Grant P20 RR016475 from the Idea
   Network of Biomedical Research Excellence (INBRE) program of the
   National Center for Research Resources. Some data from this study was
   previously presented in abstract/poster form at the 40th annual meeting
   of the Society for Neuroscience, San Diego, Calif, 13-17 November 2010
   and at the American College of Sports Medicine's The Integrative
   Physiology of Exercise, Miami Beach, Fla, 22-25 September 2010. The
   authors thank the members of the Wright lab for insightful discussion
   and comments on this paper, Dr. Hiroshi Nishimune for use of his
   microscope and assistance with image analysis, and Dr. Karra Muller for
   technical assistance with electrophysiology.
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PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1687-5214
EI 1687-5303
J9 EXP DIABETES RES
JI Exp. Diabetes Res.
PY 2011
AR 848307
DI 10.1155/2011/848307
PG 14
WC Endocrinology & Metabolism; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Research & Experimental Medicine
GA 867QJ
UT WOS:000298468600001
PM 22144990
OA Green Published, hybrid, Green Submitted
DA 2025-06-11
ER

PT J
AU Singh, SP
   Niemczyk, M
   Zimniak, L
   Zimniak, P
AF Singh, Sharda P.
   Niemczyk, Maciej
   Zimniak, Ludwika
   Zimniak, Piotr
TI Fat accumulation in Caenorhabditis elegans triggered by the
   electrophilic lipid peroxidation product 4-Hydroxynonenal (4-HNE)
SO AGING-US
LA English
DT Article
DE Lipid peroxidation; 4-hydroxynonenal; malonyl-CoA; acetyl-CoA
   carboxylase; citrate; obesity
ID ACTIVATED PROTEIN-KINASE; ACETYL-COA CARBOXYLASE; LIFE-SPAN EXTENSION;
   ADIPOSE-TISSUE; METABOLIC SYNDROME; OXIDATIVE STRESS; C-ELEGANS; ACID
   OXIDATION; GLUTATHIONE TRANSFERASE; INSULIN-RESISTANCE
AB Deposition and mobilization of fat in an organism are tightly controlled by multiple levels of endocrine and neuroendocrine regulation. Because these hormonal mechanisms ultimately act by affecting biochemical reactions of fat synthesis or utilization, obesity could be also modulated by altering directly the underlying lipid biochemistry. We have previously shown that genetically modified mice with an elevated level of the lipid peroxidation product 4-HNE become obese. We now demonstrate that the process is phylogenetically conserved and thus likely to be universal. In the nematode C. elegans, disruption of either conjugation or oxidation of 4-HNE leads to fat accumulation, where as augmentation of 4-HNE conjugation results in a lean phenotype. Moreover, direct treatment of C. elegans with synthetic 4H-NE causes increased lipid storage, directly demonstrating a causative role of 4-HNE. The postulated mechanism, which involves modulation of acetyl-CoA carboxylase activity, could contribute to the triggering and maintenance of the obese phenotype on a purely metabolic level.
C1 [Singh, Sharda P.; Niemczyk, Maciej; Zimniak, Ludwika; Zimniak, Piotr] Univ Arkansas Med Sci, Dept Pharmacol & Toxicol, Little Rock, AR 72205 USA.
   [Zimniak, Piotr] Cent Arkansas Vet Healthcare Syst, Little Rock, AR 72205 USA.
C3 University of Arkansas System; University of Arkansas Medical Sciences;
   US Department of Veterans Affairs; Veterans Health Administration (VHA);
   Central Arkansas Veterans Healthcare System
RP Zimniak, P (corresponding author), Univ Arkansas Med Sci, Dept Pharmacol & Toxicol, 4301 W Markham St, Little Rock, AR 72205 USA.
EM zimniakpiotr@uams.edu
FU National Institutes of Health [R01 AG028088, AG018845]; VA Research
   Career Scientist Award
FX This work was supported in part by National Institutes of Health grants
   R01 AG028088 and AG018845 (to P.Z.). P.Z. is a recipient of a VA
   Research Career Scientist Award.
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NR 95
TC 28
Z9 35
U1 0
U2 6
PU IMPACT JOURNALS LLC
PI ORCHARD PARK
PA 6666 E QUAKER ST, STE 1, ORCHARD PARK, NY 14127 USA
SN 1945-4589
J9 AGING-US
JI Aging-US
PD JAN
PY 2009
VL 1
IS 1
BP 68
EP 80
PG 13
WC Cell Biology; Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Geriatrics & Gerontology
GA 579DK
UT WOS:000276347200010
PM 20157589
DA 2025-06-11
ER

PT J
AU Raee, P
   Tan, SC
   Najafi, S
   Zandsalimi, F
   Low, TY
   Aghamiri, S
   Fazeli, E
   Aghapour, M
   Mofarahe, ZS
   Heidari, MH
   Fathabadi, FF
   Abdi, F
   Asouri, M
   Ahmadi, AA
   Ghanbarian, H
AF Raee, Pourya
   Tan, Shing Cheng
   Najafi, Sajad
   Zandsalimi, Farshid
   Low, Teck Yew
   Aghamiri, Shahin
   Fazeli, Elham
   Aghapour, Mahyar
   Mofarahe, Zahra Shams
   Heidari, Mohammad Hossein
   Fathabadi, Fatemeh Fadaei
   Abdi, Farid
   Asouri, Mohsen
   Ahmadi, Ali Asghar
   Ghanbarian, Hossein
TI Autophagy, a critical element in the aging male reproductive disorders
   and prostate cancer: a therapeutic point of view
SO REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
LA English
DT Review
DE Aging; Autophagy; Erectile dysfunction; Inflammaging; Male infertility;
   Prostate cancer
ID ENDOPLASMIC-RETICULUM STRESS; ERECTILE DYSFUNCTION; DIABETES-MELLITUS;
   MALE-INFERTILITY; INHIBITING APOPTOSIS; MEDIATED AUTOPHAGY; METABOLIC
   SYNDROME; CORPUS CAVERNOSUM; MESSENGER-RNA; SERTOLI-CELLS
AB Autophagy is a highly conserved, lysosome-dependent biological mechanism involved in the degradation and recycling of cellular components. There is growing evidence that autophagy is related to male reproductive biology, particularly spermatogenic and endocrinologic processes closely associated with male sexual and reproductive health. In recent decades, problems such as decreasing sperm count, erectile dysfunction, and infertility have worsened. In addition, reproductive health is closely related to overall health and comorbidity in aging men. In this review, we will outline the role of autophagy as a new player in aging male reproductive dysfunction and prostate cancer. We first provide an overview of the mechanisms of autophagy and its role in regulating male reproductive cells. We then focus on the link between autophagy and aging-related diseases. This is followed by a discussion of therapeutic strategies targeting autophagy before we end with limitations of current studies and suggestions for future developments in the field.
C1 [Raee, Pourya] Shahid Beheshti Univ Med Sci, Sch Med, Dept Biol & Anat Sci, Student Res Comm, Tehran, Iran.
   [Tan, Shing Cheng; Low, Teck Yew] Univ Kebangsaan Malaysia, UKM Med Mol Biol Inst, Kuala Lumpur, Malaysia.
   [Najafi, Sajad; Ghanbarian, Hossein] Shahid Beheshti Univ Med Sci, Sch Adv Technol Med, Dept Med Biotechnol, Tehran 193954719, Iran.
   [Zandsalimi, Farshid] Univ Tehran Med Sci, Sch Adv Technol Med, Dept Mol Med, Tehran, Iran.
   [Aghamiri, Shahin] Shahid Beheshti Univ Med Sci, Student Res Comm, Sch Adv Technol Med, Dept Med Biotechnol, Tehran, Iran.
   [Aghamiri, Shahin] Shahid Beheshti Univ Med Sci, Cellular & Mol Biol Res Ctr, Tehran, Iran.
   [Fazeli, Elham] Guilan Univ Med Sci, Mehr Fertil Res Ctr, Rasht, Iran.
   [Aghapour, Mahyar] Ulm Univ, Dept Dermatol & Allerg Dis, Ulm, Germany.
   [Mofarahe, Zahra Shams; Heidari, Mohammad Hossein; Fathabadi, Fatemeh Fadaei] Shahid Beheshti Univ Med Sci, Sch Med, Dept Biol & Anat Sci, Tehran, Iran.
   [Abdi, Farid] Islamic Azad Univ, Dept Chem Engn, Sci & Res Branch, Tehran, Iran.
   [Asouri, Mohsen; Ahmadi, Ali Asghar] Pasteur Inst Iran, North Res Ctr, Amol, Iran.
   [Ghanbarian, Hossein] Shahid Beheshti Univ Med Sci, Urogenital Stem Cell Res Ctr, Tehran, Iran.
C3 Shahid Beheshti University Medical Sciences; Universiti Kebangsaan
   Malaysia; Shahid Beheshti University Medical Sciences; Tehran University
   of Medical Sciences; Shahid Beheshti University Medical Sciences; Shahid
   Beheshti University Medical Sciences; Guilan University of Medical
   Sciences; Ulm University; Shahid Beheshti University Medical Sciences;
   Islamic Azad University; Pasteur Network; Pasteur Institute of Iran;
   Shahid Beheshti University Medical Sciences
RP Ghanbarian, H (corresponding author), Shahid Beheshti Univ Med Sci, Sch Adv Technol Med, Dept Med Biotechnol, Tehran 193954719, Iran.; Ghanbarian, H (corresponding author), Shahid Beheshti Univ Med Sci, Urogenital Stem Cell Res Ctr, Tehran, Iran.
EM hghanbarian@sbmu.ac.ir
RI Najafi, Sajad/GWN-0791-2022; Tan, Shing/J-3435-2013; FARID,
   ABDI/C-8807-2019; Aghamiri, Shahin/ABG-4656-2020; Ghanbarian,
   Hossein/P-6082-2019; Low, Teck/Q-5946-2019; Mofarahe,
   Zahra/AAF-1722-2019; Ahmadi, Ali Asghar/I-5937-2018
OI Raee, Pourya/0000-0001-7262-9658; Ahmadi, Ali Asghar/0000-0003-2286-534X
FU This study is related to project NO. 1399/61311 From Student Research
   Committee, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
   The authors also appreciate the "Student Research Committee" and
   "Research amp;amp; Technology Chancellor" in Sh [1399/61311]; Student
   Research Committee, Shahid Beheshti University of Medical Sciences,
   Tehran, Iran; "Research amp;amp; Technology Chancellor" in Shahid
   Beheshti University of Medical Sciences
FX This study is related to project NO. 1399/61311 From Student Research
   Committee, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
   The authors also appreciate the "Student Research Committee" and
   "Research & amp; Technology Chancellor" in Shahid Beheshti University of
   Medical Sciences for their financial support of this study.
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NR 237
TC 7
Z9 8
U1 0
U2 12
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1477-7827
J9 REPROD BIOL ENDOCRIN
JI Reprod. Biol. Endocrinol.
PD SEP 26
PY 2023
VL 21
IS 1
AR 88
DI 10.1186/s12958-023-01134-1
PG 23
WC Endocrinology & Metabolism; Reproductive Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Reproductive Biology
GA S3RW8
UT WOS:001070385600001
PM 37749573
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Wang, YY
   Ma, HY
   Narula, A
   Liu, L
   Ahn, KS
AF Wang, Yangyang
   Ma, Hongying
   Narula, Acharan
   Liu, Lian
   Ahn, Kwang Seok
TI Molecular targets and anticancer potential of evodiamine
SO PHYTOCHEMISTRY LETTERS
LA English
DT Article
DE Evodiamine; Anticancer; Toxicology; Molecular targets; Epigenetic
   modifications
ID STAT3 SIGNALING CASCADE; INHIBITS TUMOR-GROWTH; CELLS IN-VITRO;
   HEPATOCELLULAR-CARCINOMA; PANCREATIC-CANCER; OXIDATIVE STRESS;
   EUODIA-RUTAECARPA; BREAST-CANCER; LUNG-CANCER; APOPTOSIS
AB The identification of anticancer active ingredients and their molecular targets in traditional Chinese medicine is a great challenge in modern pharmacology research. Evodiamine is one of the bioactive components isolated from the fruit of Wu-Zhu-Yu and displays significant pharmacological activities, especially anti-inflammatory, antimicrobial, regulate metabolic syndrome and neuroprotective activity. Evodiamine has attracted great interest recently for its potential anticancer activities, and has also been found to inhibit the proliferation of various cancer cells and arrest cell cycle and cell migration. In recent years, evodiamine has been found to have potential toxic effects, mainly manifested as hepatotoxicity and cardiotoxicity. However, the pharmacological and toxicological mechanism of evodiamine is not clear. In this review, we summarized the anticancer effects of evodiamine and its target molecules in vitro and in vivo, focusing on key molecules such as HIF-1 alpha, NF-kappa B and STAT3, and proposed that epigenetic modifications (DNA methylation, histone acetylation and microRNA) mediate the regulation of key molecules, which are still being explored and excavate into clinical practice.
C1 [Wang, Yangyang] Yangtze Univ, Dept Pharmacol, Basic Med Sch, Jingzhou, Hubei, Peoples R China.
   [Ma, Hongying] Yangtze Univ, Dept Pathol & Physiol, Basic Med Sch, Jingzhou, Hubei, Peoples R China.
   [Narula, Acharan] Narula Res, Chapel Hill, NC 27516 USA.
   [Liu, Lian] Kyung Hee Univ, Dept Sci Korean Med, 24 Kyungheedae ro, Seoul 02447, South Korea.
   [Liu, Lian] Yangtze Univ, Dept Pharmacol, Basic Med Sch, Jingzhou 434023, Hubei, Peoples R China.
   [Ahn, Kwang Seok] Kyung Hee Univ, Coll Korean Med, Dept Sci Korean Med, 24 Kyungheedae ro, Seoul 02447, South Korea.
C3 Yangtze University; Yangtze University; Kyung Hee University; Yangtze
   University; Kyung Hee University
RP Liu, L (corresponding author), Yangtze Univ, Dept Pharmacol, Basic Med Sch, Jingzhou 434023, Hubei, Peoples R China.; Ahn, KS (corresponding author), Kyung Hee Univ, Coll Korean Med, Dept Sci Korean Med, 24 Kyungheedae ro, Seoul 02447, South Korea.
EM liulian@yangtzeu.edu.cn; ksahn@khu.ac.kr
FU Health Commission of Hubei Province scientific research project;
   National Research Foundation of Korea (NRF) - Korean government (MSIP); 
   [WJ2021Q015];  [NRF-2021R1I1A2060024]
FX Funding This research was funded by the Health Commission of Hubei
   Province scientific research project (NO. WJ2021Q015) . This work was
   also supported by a National Research Foundation of Korea (NRF) grant
   funded by the Korean government (MSIP) (NRF-2021R1I1A2060024) .
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NR 132
TC 6
Z9 6
U1 4
U2 24
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1874-3900
EI 1876-7486
J9 PHYTOCHEM LETT
JI Phytochem. Lett.
PD DEC
PY 2022
VL 52
BP 92
EP 103
DI 10.1016/j.phytol.2022.10.001
EA OCT 2022
PG 12
WC Plant Sciences; Chemistry, Medicinal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy
GA 5U2SA
UT WOS:000876402000002
DA 2025-06-11
ER

PT J
AU Zhao, PF
   Xu, AM
   Leung, WK
AF Zhao, Pengfei
   Xu, Aimin
   Leung, Wai Keung
TI Obesity, Bone Loss, and Periodontitis: The Interlink
SO BIOMOLECULES
LA English
DT Review
DE alveolar bone loss; bone and bones; bone remodeling; obesity;
   periodontitis
ID DIET-INDUCED OBESITY; BODY-MASS INDEX; IMMUNE-MECHANISMS RELEVANT;
   GINGIVAL OXIDATIVE STRESS; ADIPOSE-TISSUE; OSTEOBLAST DIFFERENTIATION;
   SYSTEMATIC REVIEWS; METABOLIC SYNDROME; MINERAL DENSITY; GUT MICROBIOTA
AB Obesity and periodontitis are both common health concerns that have given rise to considerable economic and societal burden worldwide. There are established negative relationships between bone metabolism and obesity, obesity and diabetes mellitus (DM), and DM and periodontitis, to name a few, with osteoporosis being considered a long-term complication of obesity. In the oral cavity, bone metabolic disorders primarily display as increased risks for periodontitis and alveolar bone loss. Obesity-driven alveolar bone loss and mandibular osteoporosis have been observed in animal models without inoculation of periodontopathogens. Clinical reports have also indicated a possible association between obesity and periodontitis. This review systematically summarizes the clinical periodontium changes, including alveolar bone loss in obese individuals. Relevant laboratory-based reports focusing on biological interlinks in obesity-associated bone remodeling via processes like hyperinflammation, immune dysregulation, and microbial dysbiosis, were reviewed. We also discuss the potential mechanism underlying obesity-enhanced alveolar bone loss from both the systemic and periodontal perspectives, focusing on delineating the practical considerations for managing periodontal disease in obese patients.
C1 [Zhao, Pengfei; Leung, Wai Keung] Univ Hong Kong, Fac Dent, Hong Kong, Peoples R China.
   [Xu, Aimin] Univ Hong Kong, Li Ka Shing Fac Med, Dept Med, Hong Kong, Peoples R China.
C3 University of Hong Kong; University of Hong Kong
RP Leung, WK (corresponding author), Univ Hong Kong, Fac Dent, Hong Kong, Peoples R China.
EM pfzhao@connect.hku.hk; amxu@hku.hk; ewkleung@hku.hk
RI ; /B-2159-2009
OI Leung, W. Keung/0000-0003-1979-910X; /0000-0002-1346-0327
FU Research Grants Council of the Hong Kong Special Administrative Region,
   China [17116819]
FX The work described in this study was substantially supported by the
   Research Grants Council of the Hong Kong Special Administrative Region,
   China (17116819).
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NR 161
TC 48
Z9 53
U1 5
U2 31
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2218-273X
J9 BIOMOLECULES
JI Biomolecules
PD JUL
PY 2022
VL 12
IS 7
AR 865
DI 10.3390/biom12070865
PG 23
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 3H4IG
UT WOS:000832000200001
PM 35883424
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Shimizu, K
   Egusa, Y
   Nishimuta, S
   Fukumura, Y
   Yoshimura, M
   Inomoto, T
   Terada, T
   Tomita, K
   Nishinaka, T
AF Shimizu, Kahori
   Egusa, Yuka
   Nishimuta, Syogo
   Fukumura, Yuri
   Yoshimura, Misato
   Inomoto, Tomoya
   Terada, Tomoyuki
   Tomita, Koji
   Nishinaka, Toru
TI Dietary calamondin supplementation slows the progression of
   non-alcoholic fatty liver disease in C57BL/6 mice fed a high-fat diet
SO INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION
LA English
DT Article
DE Calamondin; NAFLD; obesity; metabolic syndrome
ID INSULIN-RESISTANCE; OXIDATIVE STRESS; ADIPOSE-TISSUE; HEPATIC STEATOSIS;
   OBESITY; EXPRESSION; DYSLIPIDEMIA; INFLAMMATION; CONTRIBUTES; RECEPTOR
AB Obesity is associated with an increased risk of metabolic abnormalities. The citrus fruit calamondin contains nobiletin and hesperidin, which are involved in lipid metabolism, and vitamin C, which is an antioxidant. We investigated the metabolic profiles of C57BL/6 mice fed a normal diet, high-fat diet (HFD), HFD + 1% (w/w) calamondin puree (HFD + CL1), or HFD + 5% (w/w) calamondin puree (HFD + CL5). Glucose tolerance was significantly higher in HFD + CL than in HFD-fed mice. Histological analysis revealed less lipid accumulation in the livers of HFD + CL-fed mice than in those of HFD-fed control mice. Hepatocyte ballooning and large lipid droplets - key non-alcoholic fatty liver disease characteristics - were observed in HFD-fed mice after 4 weeks; however, they were nearly absent in HFD + CL-fed mice. The serum expression level of inflammation-associated Ccl2 was lower in HFD + CL-fed mice than in HFD-fed mice. Thus, calamondin may ameliorate HFD-induced metabolic disturbances, including the progression of non-alcoholic fatty liver disease.
C1 [Shimizu, Kahori; Egusa, Yuka; Nishimuta, Syogo; Fukumura, Yuri; Yoshimura, Misato; Inomoto, Tomoya; Terada, Tomoyuki; Nishinaka, Toru] Osaka Ohtani Univ, Fac Pharm, Lab Biochem, 3-11-1 Nishikiori Kita, Tondabayashi 5848540, Japan.
   [Tomita, Koji] Osaka Ohtani Univ, Fac Pharm, Lab Mol Biol, Tondabayashi, Japan.
RP Shimizu, K (corresponding author), Osaka Ohtani Univ, Fac Pharm, Lab Biochem, 3-11-1 Nishikiori Kita, Tondabayashi 5848540, Japan.
EM simizukaho@osaka-ohtani.ac.jp
RI Shimizu, Kahori/ITU-3575-2023
FU JSPS KAKENHI [JP15K18939, JP18K14964]; Osaka Ohtani University Research
   Foundation
FX This study was supported by JSPS KAKENHI [JP15K18939 and JP18K14964] and
   the Osaka Ohtani University Research Foundation (KS).
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PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0963-7486
EI 1465-3478
J9 INT J FOOD SCI NUTR
JI Int. J. Food Sci. Nutr.
PD APR 3
PY 2021
VL 72
IS 3
BP 335
EP 347
DI 10.1080/09637486.2020.1813262
EA AUG 2020
PG 13
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA RN0LO
UT WOS:000564202800001
PM 32862731
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Ban, QF
   Cheng, JJ
   Sun, XM
   Jiang, YQ
   Zhao, SB
   Song, X
   Guo, MR
AF Ban, Qingfeng
   Cheng, Jianjun
   Sun, Xiaomeng
   Jiang, Yunqing
   Zhao, Shanbo
   Song, Xiao
   Guo, Mingruo
TI Effects of a synbiotic yogurt using monk fruit extract as sweetener on
   glucose regulation and gut microbiota in rats with type 2 diabetes
   mellitus
SO JOURNAL OF DAIRY SCIENCE
LA English
DT Article
DE synbiotic yogurt; monk fruit extract; gut microbiota; type 2 diabetes
   mellitus
ID MOGROSIDE V; CARDIOVASCULAR-DISEASE; SIRAITIA-GROSVENORI;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; OXIDATIVE STRESS; CELL-FUNCTION;
   IN-VITRO; OLIGOSACCHARIDES; ASSOCIATION
AB We developed a synbiotic yogurt using monk fruit extract as a sweetener and investigated the effects of feeding the yogurt to rats with type 2 diabetes induced by streptozotocin and a high-fat diet. The rats fed the synbiotic yogurt showed greater blood glucose regulation and a significant decrease in insulin resistance and glycosylated hemoglobin compared with rats fed yogurt sweetened with sucrose, and they showed a remarkable improvement in short-chain fatty acid levels and gut microbiota status. Liver and kidney damage was also ameliorated in the rats fed the synbiotic yogurt. Immunohistochemistry analysis showed that the synbiotic yogurt inhibited beta-cell loss compared with the control yogurt. Consuming the synbiotic yogurt helped to restore the islets of Langerhans. Our results indicated that monk fruit extract may be a good alternative to sucrose for synbiotic yogurt products in people with type 2 diabetes to delay the progression of diabetes and associated complications.
C1 [Ban, Qingfeng; Cheng, Jianjun; Sun, Xiaomeng; Jiang, Yunqing; Zhao, Shanbo; Song, Xiao] Northeast Agr Univ, Coll Food Sci, Harbin 150030, Peoples R China.
   [Ban, Qingfeng; Jiang, Yunqing; Zhao, Shanbo; Song, Xiao; Guo, Mingruo] Northeast Agr Univ, Key Lab Dairy Sci, Minist Educ, Harbin 150030, Peoples R China.
   [Guo, Mingruo] Univ Vermont, Coll Agr & Life Sci, Dept Nutr & Food Sci, Burlington, VT 05405 USA.
C3 Northeast Agricultural University - China; Northeast Agricultural
   University - China; Ministry of Education - China; University of Vermont
RP Cheng, JJ (corresponding author), Northeast Agr Univ, Coll Food Sci, Harbin 150030, Peoples R China.; Guo, MR (corresponding author), Northeast Agr Univ, Key Lab Dairy Sci, Minist Educ, Harbin 150030, Peoples R China.; Guo, MR (corresponding author), Univ Vermont, Coll Agr & Life Sci, Dept Nutr & Food Sci, Burlington, VT 05405 USA.
EM cheng577@163.com; mguo@uvm.edu
RI Sun, Xiaomeng/MIQ-9590-2025
OI Sun, Xiaomeng/0000-0002-1132-8584
FU Northeast Agricultural University (Harbin, China); China Scholarship
   Council (Beijing, China)
FX The financial support for this project was provided by a special fund
   from Northeast Agricultural University (Harbin, China). The financial
   support for this project was also provided by the China Scholarship
   Council (Beijing, China). The authors have not stated any conflicts of
   interest.
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NR 53
TC 37
Z9 39
U1 1
U2 103
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0022-0302
EI 1525-3198
J9 J DAIRY SCI
JI J. Dairy Sci.
PD APR
PY 2020
VL 103
IS 4
BP 2956
EP 2968
DI 10.3168/jds.2019-17700
PG 13
WC Agriculture, Dairy & Animal Science; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture; Food Science & Technology
GA KU8WG
UT WOS:000519992900003
PM 32089310
OA Bronze
DA 2025-06-11
ER

PT J
AU Kaltenecker, D
   Themanns, M
   Mueller, KM
   Spirk, K
   Suske, T
   Merkel, O
   Kenner, L
   Luís, A
   Kozlov, A
   Haybaeck, J
   Müller, M
   Han, XN
   Moriggl, R
AF Kaltenecker, Doris
   Themanns, Madeleine
   Mueller, Kristina M.
   Spirk, Katrin
   Suske, Tobias
   Merkel, Olaf
   Kenner, Lukas
   Luis, Andreia
   Kozlov, Andrey
   Haybaeck, Johannes
   Mueller, Mathias
   Han, Xiaonan
   Moriggl, Richard
TI Hepatic growth hormone-JAK2-STAT5 signalling: Metabolic function,
   non-alcoholic fatty liver disease and hepatocellular carcinoma
   progression
SO CYTOKINE
LA English
DT Article; Proceedings Paper
CT 2nd Aegean Conference on Cytokine Signaling in Cancer (ACCSC)
CY MAY 30-JUN 04, 2017
CL Heraklion, GREECE
DE Liver; Hepatic lipid metabolism; NAFLD; Liver cancer
ID HEPATOCYTE-SPECIFIC DELETION; LEPTIN-DEFICIENT MICE; OXIDATIVE STRESS;
   GLUCOCORTICOID-RECEPTOR; PPAR-GAMMA; VITAMIN-E; INSULIN-RESISTANCE;
   LIPID-METABOLISM; GENE-EXPRESSION; MITOCHONDRIAL DYSFUNCTION
AB The rising prevalence of obesity came along with an increase in associated metabolic disorders in Western countries. Non-alcoholic fatty liver disease (NAFLD) represents the hepatic manifestation of the metabolic syndrome and is linked to primary stages of liver cancer development. Growth hormone (GH) regulates various vital processes such as energy supply and cellular regeneration. In addition, GH regulates various aspects of liver physiology through activating the Janus kinase (JAK) 2- signal transducer and activator of transcription (STAT) 5 pathway. Consequently, disrupted GH - JAK2 - STAT5 signaling in the liver alters hepatic lipid metabolism and is associated with NAFLD development in humans and mouse models. Interestingly, while STAT5 as well as JAK2 deficiency correlates with hepatic lipid accumulation, recent studies suggest that these proteins have unique ambivalent functions in chronic liver disease progression and tumorigenesis. In this review, we focus on the consequences of altered GH - JAK2 - STAT5 signaling for hepatic lipid metabolism and liver cancer development with an emphasis on lessons learned from genetic knockout models.
C1 [Kaltenecker, Doris; Themanns, Madeleine; Mueller, Kristina M.; Spirk, Katrin; Suske, Tobias; Mueller, Mathias; Moriggl, Richard] Univ Vet Med Vienna, Inst Anim Breeding & Genet, Vet Pl 1, A-1210 Vienna, Austria.
   [Kaltenecker, Doris; Themanns, Madeleine; Mueller, Kristina M.; Spirk, Katrin; Kenner, Lukas; Moriggl, Richard] Ludwig Boltzmann Inst Canc Res, Vienna, Austria.
   [Themanns, Madeleine; Spirk, Katrin; Moriggl, Richard] Med Univ Vienna, Vienna, Austria.
   [Merkel, Olaf; Kenner, Lukas] Med Univ Vienna, Dept Clin Pathol, Vienna, Austria.
   [Kenner, Lukas] Univ Vet Med Vienna, Inst Lab Anim Pathol, Vienna, Austria.
   [Luis, Andreia; Kozlov, Andrey] Ludwig Boltzmann Inst Expt & Clin Traumatol, Vienna, Austria.
   [Haybaeck, Johannes] Med Univ Graz, Diagnost & Res Ctr Mol BioMed, Inst Pathol, Graz, Austria.
   [Haybaeck, Johannes] Otto Von Guericke Univ, Dept Pathol, Fac Med, Magdeburg, Germany.
   [Haybaeck, Johannes] Med Univ Innsbruck, Dept Pathol, Innsbruck, Austria.
   [Han, Xiaonan] Chinese Acad Med Sci CAMS & Peking Union Med Coll, Key Lab Human Dis Comparat Med, Minist Hlth, Beijing, Peoples R China.
   [Han, Xiaonan] Chinese Acad Med Sci CAMS & Peking Union Med Coll, ILAS, Beijing, Peoples R China.
   [Han, Xiaonan] Cincinnati Childrens Hosp Med Ctr, Div Gastroenterol Hepatol & Nutr, Cincinnati, OH 45229 USA.
   [Mueller, Kristina M.] Fresenius Kabi Deutschland GmbH, Bad Homburg Vdh, Germany.
C3 University of Veterinary Medicine Vienna; Ludwig Boltzmann Institute;
   Ludwig Boltzmann Institute for Cancer Research; Medical University of
   Vienna; Medical University of Vienna; University of Veterinary Medicine
   Vienna; Ludwig Boltzmann Institute; Ludwig Boltzmann Institute for
   Experimental & Clinical Traumatology; Medical University of Graz; Otto
   von Guericke University; Medical University of Innsbruck; Chinese
   Academy of Medical Sciences - Peking Union Medical College; Peking Union
   Medical College; Cancer Institute & Hospital - CAMS; Chinese Academy of
   Medical Sciences - Peking Union Medical College; Peking Union Medical
   College; Cancer Institute & Hospital - CAMS; Cincinnati Children's
   Hospital Medical Center
RP Moriggl, R (corresponding author), Univ Vet Med Vienna, Inst Anim Breeding & Genet, Vet Pl 1, A-1210 Vienna, Austria.
EM richard.moriggl@vetmeduni.ac.at
RI Luis, Andreia/AAC-2823-2019; Moriggl, Richard/H-8118-2019
OI Luis, Andreia/0000-0001-7721-2835; Muller, Mathias/0000-0002-7879-3552;
   Kenner, Lukas/0000-0003-2184-1338; Han, Xiaonan/0000-0001-5368-6489;
   Kozlov, Andrey/0000-0002-0834-4997; Kaltenecker,
   Doris/0000-0002-4110-1006; Merkel, Olaf/0000-0001-5089-344X; Moriggl,
   Richard/0000-0003-0918-9463
FU Austrian Science Fund (FWF) [SFB F4704 -B20, SFB F4707-B20, SFB-F06105]
FX DK, MT, KMM, KS, TS, MM, and RM are supported by the Austrian Science
   Fund (FWF) SFB F4704 -B20, SFB F4707-B20 and SFB-F06105.
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NR 185
TC 44
Z9 45
U1 1
U2 11
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 1043-4666
EI 1096-0023
J9 CYTOKINE
JI Cytokine
PD DEC
PY 2019
VL 124
SI SI
AR 154569
DI 10.1016/j.cyto.2018.10.010
PG 12
WC Biochemistry & Molecular Biology; Cell Biology; Immunology
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Biochemistry & Molecular Biology; Cell Biology; Immunology
GA JN9YM
UT WOS:000497244900006
PM 30389231
OA hybrid
DA 2025-06-11
ER

PT J
AU Urmi, JF
   Itoh, H
   Muramatsu-Kato, K
   Kohmura-Kobayashi, Y
   Hariya, N
   Jain, D
   Tamura, N
   Uchida, T
   Suzuki, K
   Ogawa, Y
   Shiraki, N
   Mochizuki, K
   Kubota, T
   Kanayama, N
AF Urmi, Jeenat Ferdous
   Itoh, Hiroaki
   Muramatsu-Kato, Keiko
   Kohmura-Kobayashi, Yukiko
   Hariya, Natsuyo
   Jain, Divyanu
   Tamura, Naoaki
   Uchida, Toshiyuki
   Suzuki, Kazunao
   Ogawa, Yoshihiro
   Shiraki, Nobuaki
   Mochizuki, Kazuki
   Kubota, Takeo
   Kanayama, Naohiro
TI Plasticity of histone modifications around Cidea and Cidec genes with
   secondary bile in the amelioration of developmentally-programmed hepatic
   steatosis
SO SCIENTIFIC REPORTS
LA English
DT Article
ID FATTY LIVER-DISEASE; METABOLIC SYNDROME; H3K27 METHYLATION;
   BIRTH-WEIGHT; ER STRESS; H3; EXPRESSION; PROTEINS; EPIGENOMICS;
   MECHANISMS
AB We recently reported that a treatment with tauroursodeoxycholic acid (TUDCA), a secondary bile acid, improved developmentally-deteriorated hepatic steatosis in an undernourishment (UN, 40% caloric restriction) in utero mouse model after a postnatal high-fat diet (HFD). We performed a microarray analysis and focused on two genes (Cidea and Cidec) because they are enhancers of lipid droplet (LD) sizes in hepatocytes and showed the greatest up-regulation in expression by UN that were completely recovered by TUDCA, concomitant with parallel changes in LD sizes. TUDCA remodeled developmentally-induced histone modifications (dimethylation of H3K4, H3K27, or H3K36), but not DNA methylation, around the Cidea and Cidec genes in UN pups only. Changes in these histone modifications may contribute to the markedly down-regulated expression of Cidea and Cidec genes in UN pups, which was observed in the alleviation of hepatic fat deposition, even under HFD. These results provide an insight into the future of precision medicine for developmentally-programmed hepatic steatosis by targeting histone modifications.
C1 [Urmi, Jeenat Ferdous; Itoh, Hiroaki; Muramatsu-Kato, Keiko; Kohmura-Kobayashi, Yukiko; Jain, Divyanu; Tamura, Naoaki; Uchida, Toshiyuki; Suzuki, Kazunao; Kanayama, Naohiro] Hamamatsu Univ Sch Med, Dept Obstet & Gynecol, Hamamatsu, Shizuoka, Japan.
   [Hariya, Natsuyo] Yamanashi Gakuin Univ, Fac Hlth & Nutr, Dept Nutr, Kofu, Yamanashi, Japan.
   [Ogawa, Yoshihiro] Kyushu Univ, Grad Sch Med Sci, Dept Med & Bioregulatory Sci, Fukuoka, Fukuoka, Japan.
   [Ogawa, Yoshihiro] Tokyo Med & Dent Univ, Grad Sch Med & Dent Sci, Dept Mol & Cellular Metab, Tokyo, Japan.
   [Shiraki, Nobuaki] Tokyo Inst Technol, Sch Life Sci & Technol, Dept Life Sci & Technol, Yokohama, Kanagawa, Japan.
   [Mochizuki, Kazuki] Univ Yamanashi, Fac Life & Environm Sci, Dept Local Produce & Food Sci, Lab Food & Nutr Sci, Kofu, Yamanashi, Japan.
   [Kubota, Takeo] Seitoku Univ, Fac Child Studies, Matsudo, Chiba, Japan.
C3 Hamamatsu University School of Medicine; Kyushu University; Institute of
   Science Tokyo; Tokyo Medical & Dental University (TMDU); Institute of
   Science Tokyo; Tokyo Institute of Technology; University of Yamanashi
RP Itoh, H (corresponding author), Hamamatsu Univ Sch Med, Dept Obstet & Gynecol, Hamamatsu, Shizuoka, Japan.
EM hitou-endo@umin.ac.jp
RI Urmi, Jeenat/AFA-2946-2022
OI shiraki, nobuaki/0000-0001-6708-9976; Jain, Divyanu/0000-0002-7883-3470;
   Ogawa, Yoshihiro/0000-0002-0834-2836
FU MEXT KAKENHI [15H04882, JP16K15703]
FX This work was supported in part by MEXT KAKENHI (Grants-in-Aid for
   Scientific Research) Grant Numbers 15H04882 and JP16K15703.
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NR 50
TC 8
Z9 8
U1 0
U2 4
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD NOV 19
PY 2019
VL 9
AR 17100
DI 10.1038/s41598-019-52943-7
PG 12
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA JO6QJ
UT WOS:000497701800057
PM 31745102
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Sathasivam, R
   Ki, JS
AF Sathasivam, Ramaraj
   Ki, Jang-Seu
TI A Review of the Biological Activities of Microalgal Carotenoids and
   Their Potential Use in Healthcare and Cosmetic Industries
SO MARINE DRUGS
LA English
DT Review
DE carotenoids; microalgae; anti-angiogenic; cardioprotective activity;
   anti-cancer; anti-diabetic; anti-inflammatory; anti-obesity;
   anti-oxidant; beauty
ID MESSENGER-RNA EXPRESSION; INFLAMMATION IN-VITRO; NITRIC-OXIDE SYNTHASE;
   DIET-INDUCED OBESITY; NF-KAPPA-B; BETA-CAROTENE; ANTIOXIDANT ACTIVITY;
   MARINE CAROTENOIDS; METABOLIC SYNDROME; OXIDATIVE STRESS
AB Carotenoids are natural pigments that play pivotal roles in many physiological functions. The characteristics of carotenoids, their effects on health, and the cosmetic benefits of their usage have been under investigation for a long time; however, most reviews on this subject focus on carotenoids obtained from several microalgae, vegetables, fruits, and higher plants. Recently, microalgae have received much attention due to their abilities in producing novel bioactive metabolites, including a wide range of different carotenoids that can provide for health and cosmetic benefits. The main objectives of this review are to provide an updated view of recent work on the health and cosmetic benefits associated with carotenoid use, as well as to provide a list of microalgae that produce different types of carotenoids. This review could provide new insights to researchers on the potential role of carotenoids in improving human health.
C1 [Sathasivam, Ramaraj; Ki, Jang-Seu] Sangmyung Univ, Dept Biotechnol, Seoul 03016, South Korea.
C3 Sangmyung University
RP Ki, JS (corresponding author), Sangmyung Univ, Dept Biotechnol, Seoul 03016, South Korea.
EM ramarajbiotech@gmail.com; kijs@smu.ac.kr
RI Sathasivam, Ramaraj/AAD-4800-2020
OI SATHASIVAM, RAMARAJ/0000-0002-3516-9274
FU National Research Foundation of Korea - Korean Government
   [2015M1A5A1041805, 2016R1D1A1A09920198]; National Fisheries Research and
   Development [R2017047]
FX We thank S. Abassi for critical comments and English editing on the
   early version of manuscript. This work was supported by the National
   Research Foundation of Korea Grant funded by the Korean Government
   (2015M1A5A1041805 and 2016R1D1A1A09920198), and by a grant from the
   National Fisheries Research and Development (R2017047) funded to J.-S.
   Ki.
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NR 191
TC 290
Z9 304
U1 8
U2 167
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1660-3397
J9 MAR DRUGS
JI Mar. Drugs
PD JAN
PY 2018
VL 16
IS 1
AR 26
DI 10.3390/md16010026
PG 31
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA FU8SN
UT WOS:000424125600026
PM 29329235
OA gold, Green Published, Green Submitted
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Kunutsor, SK
AF Kunutsor, Setor K.
TI Gamma-glutamyltransferase-friend or foe within?
SO LIVER INTERNATIONAL
LA English
DT Review
DE dementia; diabetes; fracture; gamma-glutamyltransferase; mortality;
   vascular disease
ID FATTY LIVER-DISEASE; GLUTAMYL-TRANSFERASE ACTIVITY; CARDIOVASCULAR
   RISK-FACTORS; DOSE-RESPONSE METAANALYSIS; GENOME-WIDE ASSOCIATION;
   CHRONIC KIDNEY-DISEASE; ALL-CAUSE MORTALITY; METABOLIC SYNDROME;
   OXIDATIVE STRESS; HEART-FAILURE
AB Gamma-glutamyltransferase (GGT) is a liver enzyme, which is located on the plasma membranes of most cells and organ tissues, but more commonly in hepatocytes, and is routinely used in clinical practice to help indicate liver injury and as a marker of excessive alcohol consumption. Among the liver enzymes, important advances have especially been made in understanding the physiological functions of GGT. The primary role of GGT is the extracellular catabolism of glutathione, the major thiol antioxidant in mammalian cells, which plays a relevant role in protecting cells against oxidants produced during normal metabolism; GGT, therefore, plays an important role in cellular defence. Beyond its physiological functions, circulating serum GGT has been linked to a remarkable array of chronic conditions and diseases, which include nonalcoholic fatty liver disease, vascular and nonvascular diseases and mortality outcomes. This review summarizes the available epidemiological and genetic evidence for the associations between GGT and these adverse outcomes, the postulated biologic mechanisms underlying these associations, outlines areas of outstanding uncertainty and the implications for clinical practice.
C1 [Kunutsor, Setor K.] Univ Bristol, Sch Clin Sci, Bristol, Avon, England.
C3 University of Bristol
RP Kunutsor, SK (corresponding author), Univ Bristol, Sch Clin Sci, Bristol, Avon, England.
EM skk31@cantab.net
RI Kunutsor, Setor/H-9807-2019
OI KUNUTSOR, SETOR/0000-0002-2625-0273
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NR 129
TC 122
Z9 128
U1 2
U2 16
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1478-3223
EI 1478-3231
J9 LIVER INT
JI Liver Int.
PD DEC
PY 2016
VL 36
IS 12
BP 1723
EP 1734
DI 10.1111/liv.13221
PG 12
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA EJ3HS
UT WOS:000393103800001
PM 27512925
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Segal, MS
   Gollub, E
   Johnson, RJ
AF Segal, Mark S.
   Gollub, Elizabeth
   Johnson, Richard J.
TI Is the fructose index more relevant with regards to cardiovascular
   disease than the glycemic index?
SO EUROPEAN JOURNAL OF NUTRITION
LA English
DT Review
DE cardiovascular disease; fructose; metabolic syndrome; obesity; uric acid
ID SERUM URIC-ACID; XANTHINE-OXIDASE INHIBITION; SALT-SENSITIVE
   HYPERTENSION; CHRONIC HEART-FAILURE; IMPROVES ENDOTHELIAL FUNCTION;
   INCREASED OXIDATIVE STRESS; IMMUNE CELL INFILTRATION; BLOOD-PRESSURE;
   INSULIN-RESISTANCE; DIETARY FRUCTOSE
AB The glycemic index (G.I.) is a means for categorizing carbohydrates based on their ability to raise blood glucose, subsequently this index has been popularized as a way for selecting foods to reduce the risk for obesity, diabetes, and cardiovascular disease. We suggest that the G.I. is better aimed at identifying foods that stimulate insulin secretion rather than foods that stimulate insulin resistance. In this regard, fructose has a low G.I. but may be causally linked with the obesity and cardiovascular disease epidemic. The reported association of high G.I. with cardiovascular dis- ease may be due to the association of sugar intake which contains fructose, but which has a high G.I. due to its glucose content. We propose the use of a fructose index to categorize foods and propose studies to determine the effect of low fructose diets as a means to prevent obesity, diabetes, and cardiovascular disease in the population.
C1 Univ Florida, Div Nephrol Hypertens & Transplantat, Gainesville, FL 32611 USA.
C3 State University System of Florida; University of Florida
RP Johnson, RJ (corresponding author), Univ Florida, Div Nephrol Hypertens & Transplantat, Gainesville, FL 32611 USA.
EM johnsrj@medicine.ufl.edu
RI Silver, Heidi/KLZ-4262-2024
OI Segal, Mark/0000-0002-5502-2042
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NR 170
TC 57
Z9 65
U1 1
U2 15
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1436-6207
EI 1436-6215
J9 EUR J NUTR
JI Eur. J. Nutr.
PD OCT
PY 2007
VL 46
IS 7
BP 406
EP 417
DI 10.1007/s00394-007-0680-9
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 223BV
UT WOS:000250345500006
PM 17763967
DA 2025-06-11
ER

PT J
AU Pang, ML
   Wang, SD
   Shi, TY
   Chen, JS
AF Pang, Mingli
   Wang, Shidi
   Shi, Tianyi
   Chen, Jinsong
TI Overview of MitoQ on prevention and management of cardiometabolic
   diseases: a scoping review
SO FRONTIERS IN CARDIOVASCULAR MEDICINE
LA English
DT Review
DE MitoQ; cardiometabolic diseases; metabolic health; cardiovascular
   diseases; liver health
ID MITOCHONDRIAL-TARGETED ANTIOXIDANT; PANCREATIC BETA-CELLS; OXIDATIVE
   STRESS; METABOLIC SYNDROME; VASCULAR FUNCTION; KIDNEY-DISEASE;
   INFLAMMATION; SUPPLEMENTATION; FEATURES
AB Background The exploration of mitochondrial-targeted antioxidants represented a burgeoning field of research with significant implications for cardiometabolic diseases (CMD). The studies reviewed in this scoping analysis collectively highlighted the effect of MitoQ on prevention and management of CMD and underlying mechanisms were discussed, mainly including cardiovascular diseases (CVDs), liver health and others. Methods This scoping review aimed to synthesize current research on the health impacts of MitoQ on CMD, focusing primarily on human-based clinical trials. While the primary focus was on human trials, in vivo and in vitro studies were referenced as supplementary material to provide a broader understanding of MitoQ's mechanisms and potential effects. Results This scoping review had synthesized the findings that collectively contributed to the understanding of mitochondrial-targeted antioxidants and their role in CMD. Conclusion The synthesis of these findings illustrated a broad spectrum of benefits ranging from enhanced insulin secretion to improved lipid profiles and mitochondrial function, yet the path to clinical application required further investigation on appropriate doses and populations.
C1 [Pang, Mingli; Chen, Jinsong] Zhejiang Univ, Sch Publ Affairs, Hangzhou, Peoples R China.
   [Pang, Mingli; Chen, Jinsong] Univ Auckland, Natl Inst Hlth Innovat, Sch Populat Hlth, Auckland, New Zealand.
   [Wang, Shidi] Fudan Univ, Dept Social Med & Hlth Care Management, Shanghai, Peoples R China.
   [Shi, Tianyi] Univ Auckland, Fac Med & Hlth Sci, Sch Populat Hlth, Auckland, New Zealand.
   [Chen, Jinsong] Hangzhou City Univ, Fac Publ Adm, Sch Law, Hangzhou, Peoples R China.
C3 Zhejiang University; University of Auckland; Fudan University;
   University of Auckland; Hangzhou City University
RP Chen, JS (corresponding author), Zhejiang Univ, Sch Publ Affairs, Hangzhou, Peoples R China.; Chen, JS (corresponding author), Univ Auckland, Natl Inst Hlth Innovat, Sch Populat Hlth, Auckland, New Zealand.; Chen, JS (corresponding author), Hangzhou City Univ, Fac Publ Adm, Sch Law, Hangzhou, Peoples R China.
EM 0623d62@zju.edu.cn
RI Shi, Tianyi/LLK-8073-2024; Pang, Mingli/LLL-8390-2024
FU MitoQ Ltd
FX The research team greatly appreciated the funding support. The authors
   were deeply grateful to MitoQ research team for their valuable insights
   and consultations, which greatly enhanced the quality of this study.
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NR 55
TC 0
Z9 0
U1 2
U2 2
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2297-055X
J9 FRONT CARDIOVASC MED
JI Front. Cardiovasc. Med.
PD MAR 11
PY 2025
VL 12
AR 1506460
DI 10.3389/fcvm.2025.1506460
PG 12
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 0MX8M
UT WOS:001451183500001
PM 40134978
OA gold
DA 2025-06-11
ER

PT J
AU Fiorenza, M
   Onslev, J
   Henríquez-Olguín, C
   Persson, KW
   Hesselager, SA
   Jensen, TE
   Wojtaszewski, JFP
   Hostrup, M
   Bangsbo, J
AF Fiorenza, Matteo
   Onslev, Johan
   Henriquez-Olguin, Carlos
   Persson, Kaspar W.
   Hesselager, Sofie A.
   Jensen, Thomas E.
   Wojtaszewski, Jorgen F. P.
   Hostrup, Morten
   Bangsbo, Jens
TI Reducing the mitochondrial oxidative burden alleviates lipid-induced
   muscle insulin resistance in humans
SO SCIENCE ADVANCES
LA English
DT Article
ID HUMAN SKELETAL-MUSCLE; FREE FATTY-ACIDS; ANGIOPOIETIN-LIKE PROTEIN-4;
   IMPROVES GLUCOSE-TOLERANCE; OXYGEN SPECIES ROS; FACTOR-KAPPA-B; TARGETED
   ANTIOXIDANT; ELECTRON-TRANSPORT; METABOLIC SYNDROME; RESPIRATORY-CHAIN
AB Preclinical models suggest mitochondria-derived oxidative stress as an underlying cause of insulin resistance. However, it remains unknown whether this pathophysiological mechanism is conserved in humans. Here, we used an invasive in vivo mechanistic approach to interrogate muscle insulin action while selectively manipulating the mitochondrial redox state in humans. To this end, we conducted insulin clamp studies combining intravenous infusion of a lipid overload with intake of a mitochondria-targeted antioxidant (mitoquinone). Under lipid overload, selective modulation of mitochondrial redox state by mitoquinone enhanced insulin-stimulated glucose uptake in skeletal muscle. Mechanistically, mitoquinone did not affect canonical insulin signaling but augmented insulin-stimulated glucose transporter type 4 (GLUT4) translocation while reducing the mitochondrial oxidative burden under lipid oversupply. Complementary ex vivo studies in human muscle fibers exposed to high intracellular lipid levels revealed that mitoquinone improves features of mitochondrial bioenergetics, including diminished mitochondrial H2O2 emission. These findings provide translational and mechanistic evidence implicating mitochondrial oxidants in the development of lipid-induced muscle insulin resistance in humans.
C1 [Fiorenza, Matteo; Hostrup, Morten; Bangsbo, Jens] Univ Copenhagen, Dept Nutr Exercise & Sports, August Krogh Sect Human Physiol, DK-2100 Copenhagen, Denmark.
   [Fiorenza, Matteo] Univ Copenhagen, Dept Biomed Sci, DK-2200 Copenhagen, Denmark.
   [Onslev, Johan; Henriquez-Olguin, Carlos; Persson, Kaspar W.; Hesselager, Sofie A.; Jensen, Thomas E.; Wojtaszewski, Jorgen F. P.] Univ Copenhagen, Dept Nutr Exercise & Sports, August Krogh Sect Mol Physiol, DK-2100 Copenhagen, Denmark.
   [Henriquez-Olguin, Carlos] Univ Finis Terrae, Fac Med, Exercise Sci Lab, Santiago 1509, Chile.
C3 University of Copenhagen; University of Copenhagen; University of
   Copenhagen; Universidad Finis Terrae
RP Fiorenza, M (corresponding author), Univ Copenhagen, Dept Nutr Exercise & Sports, August Krogh Sect Human Physiol, DK-2100 Copenhagen, Denmark.; Fiorenza, M (corresponding author), Univ Copenhagen, Dept Biomed Sci, DK-2200 Copenhagen, Denmark.
EM matteo.fiorenza@sund.ku.dk
RI Fiorenza, Matteo/AAA-1887-2020; Wojtaszewski, Jørgen/P-6583-2014;
   Hostrup, Morten/D-9053-2015; Henriquez-Olguin, Carlos/K-7671-2012;
   Bangsbo, Jens/A-7192-2015; Jensen, Thomas/E-1215-2015
OI Hostrup, Morten/0000-0002-6201-2483; Henriquez-Olguin,
   Carlos/0000-0002-9315-9365; Bangsbo, Jens/0000-0003-1305-9274; Fiorenza,
   Matteo/0000-0002-8377-0857; Onslev, Johan/0000-0002-5143-9377;
   wojtaszewski, jorgen/0000-0001-8185-3408; Persson, Kaspar
   Wredstrom/0000-0001-9557-3503; Jensen, Thomas/0000-0001-6139-8268
FU Novo Nordisk Foundation [NNF18OC0052883]; Danish Diabetes Academy
   [NNF17SA0031406]
FX This work was supported by Novo Nordisk Foundation grant NNF18OC0052883
   (M.F. and J.B.) and Danish Diabetes Academy grant NNF17SA0031406 (J.O.
   and C.H.-O.).
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NR 123
TC 8
Z9 8
U1 7
U2 11
PU AMER ASSOC ADVANCEMENT SCIENCE
PI WASHINGTON
PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA
SN 2375-2548
J9 SCI ADV
JI Sci. Adv.
PD OCT 30
PY 2024
VL 10
IS 44
AR eadq4461
DI 10.1126/sciadv.adq4461
PG 20
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA K7V9E
UT WOS:001345933500012
PM 39475607
OA gold, Green Accepted
DA 2025-06-11
ER

PT J
AU Coman, AE
   Ceasovschih, A
   Petroaie, AD
   Popa, E
   Lionte, C
   Bologa, C
   Haliga, RE
   Cosmescu, A
   Slanina, AM
   Bacusca, AI
   Sorodoc, V
   Sorodoc, L
AF Coman, Adorata Elena
   Ceasovschih, Alexandr
   Petroaie, Antoneta Dacia
   Popa, Elena
   Lionte, Catalina
   Bologa, Cristina
   Haliga, Raluca Ecaterina
   Cosmescu, Adriana
   Slanina, Ana Maria
   Bacusca, Agnes Iacinta
   Sorodoc, Victoria
   Sorodoc, Laureniu
TI The Significance of Low Magnesium Levels in COVID-19 Patients
SO MEDICINA-LITHUANIA
LA English
DT Review
DE COVID-19; SARS-CoV-2; magnesium; endothelial dysfunction; coagulation;
   inflammation; "long COVID-19" syndrome; pregnancy
ID DIETARY MAGNESIUM; OXIDATIVE STRESS; ENDOTHELIAL DYSFUNCTION;
   INTRAVENOUS MAGNESIUM; INFLAMMATORY RESPONSE; METABOLIC SYNDROME; STENT
   THROMBOSIS; TISSUE FACTOR; VITAMIN-D; DEFICIENCY
AB Magnesium is the fourth most common mineral in the human body and the second richest intracellular cation. This element is necessary for many physiological reactions, especially in the cardiovascular and respiratory systems. COVID-19 is an infectious disease caused by SARS-CoV-2. The majority of people who become ill as a result of COVID-19 have mild-to-moderate symptoms and recover without specific treatment. Moreover, there are people who develop severe forms of COVID-19, which require highly specialized medical assistance. Magnesium deficiency may play a role in the pathophysiology of infection with SARS-CoV-2. The primary manifestation of COVID-19 remains respiratory, but the virus can spread to other organs and tissues, complicating the clinical picture and culminating in multiorgan failure. The key mechanisms involved in the disease include direct viral cytotoxicity, endothelial dysfunction, and exaggerated release of inflammatory cytokines. The aim of this review was to summarize the available data regarding the role of magnesium in COVID-19 patients and its particularities in different clinical settings.
C1 [Coman, Adorata Elena; Petroaie, Antoneta Dacia; Popa, Elena; Cosmescu, Adriana; Slanina, Ana Maria; Bacusca, Agnes Iacinta] Grigore T Popa Univ Med & Pharm Iasi, Prevent Med & Interdisciplinar Dept, Iasi 700115, Romania.
   [Ceasovschih, Alexandr; Bologa, Cristina; Haliga, Raluca Ecaterina; Sorodoc, Victoria; Sorodoc, Laureniu] Sf Spiridon Clin Emergency Hosp, Internal Med Dept 2, Iasi 700111, Romania.
   [Lionte, Catalina; Bologa, Cristina; Haliga, Raluca Ecaterina; Sorodoc, Victoria; Sorodoc, Laureniu] Grigore T Popa Univ Med & Pharm, Fac Med, Internal Med Dept, Iasi 700115, Romania.
C3 Grigore T Popa University of Medicine & Pharmacy; Grigore T Popa
   University of Medicine & Pharmacy
RP Ceasovschih, A (corresponding author), Sf Spiridon Clin Emergency Hosp, Internal Med Dept 2, Iasi 700111, Romania.; Lionte, C (corresponding author), Grigore T Popa Univ Med & Pharm, Fac Med, Internal Med Dept, Iasi 700115, Romania.
EM alexandr.ceasovschih@yahoo.com; catalina.lionte@umfiasi.ro
RI Ceasovschih, Alexandr/AAF-2773-2021; Slanina, Ana-Maria/HZK-5116-2023;
   Cristina, Bologa/KWU-8665-2024; petroaie, antoneta/AAF-4463-2020; Popa,
   Elena/LTZ-5219-2024; Victorita, Sorodoc/AGH-5818-2022; Coman, Elena
   Adorata/D-2759-2015; Elena, Popa/B-1808-2015; LIONTE,
   CATALINA/A-5283-2013
OI Haliga, Raluca Ecaterina/0000-0002-4674-5580; Victorita,
   Sorodoc/0000-0003-1721-2360; Coman, Elena Adorata/0000-0002-6348-2954;
   Elena, Popa/0000-0003-2207-5129; Slanina, Ana-Maria/0000-0002-6456-9744;
   PETROAIE, ANTONETA DACIA/0000-0002-1239-8058; LIONTE,
   CATALINA/0000-0002-0525-0645; Ceasovschih, Alexandr/0000-0002-0043-9051
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NR 153
TC 17
Z9 17
U1 4
U2 21
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1010-660X
EI 1648-9144
J9 MEDICINA-LITHUANIA
JI Med. Lith.
PD FEB
PY 2023
VL 59
IS 2
AR 279
DI 10.3390/medicina59020279
PG 20
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 9J2MP
UT WOS:000940028000001
PM 36837480
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Izquierdo, AG
   Crujeiras, AB
AF Izquierdo, Andrea G.
   Crujeiras, Ana B.
TI Role of epigenomic mechanisms in the onset and management of insulin
   resistance
SO REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
LA English
DT Review
DE DNA methylation; Non-coding RNA; Glucose homeostasis; Insulin
   sensitivity; Type 2 diabetes; Biomarkers
ID GENOMIC DNA METHYLATION; ENDOPLASMIC-RETICULUM STRESS; MITOCHONDRIAL
   DYSFUNCTION; METABOLIC SYNDROME; NONCODING RNAS; ADIPOSE-TISSUE;
   EPIGENETIC MODIFICATIONS; THERAPEUTIC TARGET; GENE-EXPRESSION; EMERGING
   FIELD
AB The prevalence of insulin resistance (IR) is increasing rapidly worldwide and it is a relevant health problem because it is associated with several diseases, such as type 2 diabetes, cardiovascular disorders and cancer. Understanding the mechanisms involved in IR onset and progression will open new avenues for identifying biomarkers for preventing and treating IR and its co-diseases. Epigenetic mechanisms such as DNA methylation are important factors that mediate the environmental effect in the genome by regulating gene expression and consequently its effect on the phenotype and the development of disease. Taking into account that IR results from a complex interplay between genes and the environment and that epigenetic marks are reversible, disentangling the relationship between IR and epigenetics will provide new tools to improve the management and prevention of IR. Here, we review the current scientific evidence regarding the association between IR and epigenetic markers as mechanisms involved in IR development and potential management.
C1 [Izquierdo, Andrea G.; Crujeiras, Ana B.] Complejo Hosp Univ Santiago CHUS SERGAS, Inst Invest Sanitaria IDIS, Epigen Endocrinol & Nutr Grp, C Choupana S-N, Santiago De Compostela 15706, Spain.
   [Izquierdo, Andrea G.; Crujeiras, Ana B.] CIBER Fisiopatol Obesidad & Nutr CIBERobn, Madrid, Spain.
C3 CIBER - Centro de Investigacion Biomedica en Red; CIBEROBN
RP Crujeiras, AB (corresponding author), Complejo Hosp Univ Santiago CHUS SERGAS, Inst Invest Sanitaria IDIS, Epigen Endocrinol & Nutr Grp, C Choupana S-N, Santiago De Compostela 15706, Spain.; Crujeiras, AB (corresponding author), CIBER Fisiopatol Obesidad & Nutr CIBERobn, Madrid, Spain.
EM anabelencrujeiras@hotmail.com
RI Izquierdo, Andrea G/HLX-1356-2023; Crujeiras, Ana B/ABA-8866-2021
OI Izquierdo, Andrea G/0000-0002-0846-8834; Crujeiras, Ana
   B/0000-0003-4392-0301
FU Centro de Investigacion Biomedica en Red de la Fisiopatologia de la
   Obesidad y Nutricion (CIBERobn); Instituto de Salud Carlos III-ISCIII -
   European Regional Development Fund (FEDER) [PI17/01287, CP17/00088];
   ISCIII [CP17/00088]
FX The research of the author's lab is supported by Centro de Investigacion
   Biomedica en Red de la Fisiopatologia de la Obesidad y Nutricion
   (CIBERobn) and grants from the Instituto de Salud Carlos III-ISCIII
   (PI17/01287, CP17/00088) co-financed by the European Regional
   Development Fund (FEDER). Ana B Crujeiras is funded by a research
   contract "Miguel Servet" (CP17/00088) from the ISCIII.
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NR 130
TC 17
Z9 18
U1 0
U2 10
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1389-9155
EI 1573-2606
J9 REV ENDOCR METAB DIS
JI Rev. Endocr. Metab. Disord.
PD MAR
PY 2019
VL 20
IS 1
BP 89
EP 102
DI 10.1007/s11154-019-09485-0
PG 14
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA IC8DH
UT WOS:000471206000011
PM 30887406
DA 2025-06-11
ER

PT J
AU Cendales, B
   Useche, S
   Gómez, V
AF Cendales, Boris
   Useche, Sergio
   Gomez, Viviola
TI Psychosocial Work Factors, Blood Pressure and Psychological Strain in
   Male Bus Operators
SO INDUSTRIAL HEALTH
LA English
DT Article
DE Demands; Control; Effort; Rewards; Psychological strain; Blood pressure;
   Bus operators
ID EFFORT-REWARD IMBALANCE; CORONARY-HEART-DISEASE; CONTROL SUPPORT MODEL;
   JOB-STRESS-MODELS; INTERNATIONAL PROTOCOL; CARDIOVASCULAR-DISEASE;
   PROFESSIONAL DRIVERS; METABOLIC SYNDROME; MEASURING DEVICE; POSITION
   SENSOR
AB The research aim was to predict the bus operators' blood pressure (BP) and psychological strain using a combination of the Job-Demand Control (JDC) and Effort-Reward Imbalance (ERI) models. The study was conducted with a sample of 139 bus operators in the city of Bogota (Colombia), who answered a questionnaire that included the Job Content Questionnaire (JCQ), the ERI Questionnaire, and the General Health Questionnaire (GHQ). Four consecutive BP readings taken in the workplace were averaged to calculate an estimation of the bus operators' BP. By conducting multiple linear regressions it was found that, taken together, JDC and ERI models explain 10% (F-(11,F-139)=2,502; p=0.00) of systolic BP variance, and 34% (F-(6,F-139)=8,638; p=0.00) of psychological strain variance. These results suggest that the JDC and ERI predictors provide complementary information which increases the probability of accurately model the bus operators' health.
C1 [Cendales, Boris; Useche, Sergio; Gomez, Viviola] Univ Los Andes, Dept Psychol, Bogota, Colombia.
C3 Universidad de los Andes (Colombia)
RP Cendales, B (corresponding author), Univ Los Andes, Dept Psychol, Bogota, Colombia.
EM be.cendales42@uniandes.edu.co
RI ; Useche, Sergio/O-7552-2014
OI Cendales, Boris/0000-0002-6904-7339; Gomez, Viviola/0000-0002-1066-9483;
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NR 72
TC 16
Z9 17
U1 1
U2 15
PU NATL INST OCCUPATIONAL SAFETY & HEALTH, JAPAN
PI KAWASAKI KANAGAWA
PA 21-1 NAGAO 6-CHOME TAMA-KU, KAWASAKI KANAGAWA, 214, JAPAN
SN 0019-8366
EI 1880-8026
J9 IND HEALTH
JI Ind. Health
PD JUL
PY 2014
VL 52
IS 4
BP 279
EP 288
DI 10.2486/indhealth.2013-0156
PG 10
WC Environmental Sciences; Public, Environmental & Occupational Health;
   Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health; Toxicology
GA AM9RK
UT WOS:000340218500002
PM 24869893
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Hu, Y
   Liu, J
   Wang, JF
   Liu, QS
AF Hu, Yi
   Liu, Jing
   Wang, Junfeng
   Liu, Qingsong
TI The controversial links among calorie restriction, SIRT1, and
   resveratrol
SO FREE RADICAL BIOLOGY AND MEDICINE
LA English
DT Review
DE Calorie restriction; SIRT1; Resveratrol; Deacetylase; Life span
ID ACTIVATED PROTEIN-KINASE; SMALL-MOLECULE ACTIVATORS; LIFE-SPAN
   EXTENSION; OXIDATIVE STRESS; ENDOTHELIAL-CELLS;
   SACCHAROMYCES-CEREVISIAE; HISTONE DEACETYLASE; DIETARY RESTRICTION;
   METABOLIC SYNDROME; INDUCED APOPTOSIS
AB It has been widely known that slow metabolism induced by calorie restriction (CR) can extend the life span of model organisms though the underlying mechanism remains poorly understood. Accumulated evidence suggests that SIRT1 may be actively involved in CR-induced signaling pathways. As a putative activator of SIRT1, resveratrol, known for the French paradox, can partially mimic the physiological effects of CR. While the deacetylase activity of SIRT1 is important for the beneficial effects of resveratrol, resveratrol-induced SIRT1 activation has recently been challenged by the observations that resveratrol could not induce SIRT1-mediated deacetylation of native substrates in vitro. To resolve the discrepancy of resveratrol-induced activation of SIRT1 deacetylase activity between the in vitro and in vivo assays, a model of indirect SIRT1 activation by resveratrol is proposed. In this review, we will discuss the emerging roles of SIRT1 and resveratrol in CR and focus on debate over the links between SIRT1 and resveratrol. (C) 2011 Elsevier Inc. All rights reserved.
C1 [Liu, Qingsong] Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02115 USA.
   [Hu, Yi] Harvard Univ, Sch Med, Ctr Neurol Dis, Cambridge, MA 02139 USA.
   [Hu, Yi] Brigham & Womens Hosp, Cambridge, MA 02139 USA.
   [Liu, Jing; Wang, Junfeng; Liu, Qingsong] Chinese Acad Sci, High Field Magnet Lab, Hefei 230031, Anhui, Peoples R China.
   [Liu, Jing] Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA.
   [Liu, Qingsong] Harvard Univ, Sch Med, Dept Biol Chem & Mol Pharmacol, Boston, MA 02115 USA.
C3 Harvard University; Harvard University Medical Affiliates; Dana-Farber
   Cancer Institute; Harvard University; Harvard University; Harvard
   University Medical Affiliates; Brigham & Women's Hospital; Chinese
   Academy of Sciences; Hefei Institutes of Physical Science, CAS; Harvard
   University; Harvard Medical School; Harvard University; Harvard Medical
   School
RP Liu, QS (corresponding author), Dana Farber Canc Inst, Dept Canc Biol, 44 Binney St, Boston, MA 02115 USA.
EM nkliuqs97@gmail.com
RI HU, YI/L-3309-2016; Liu, Qingsong/AFS-0714-2022; Liu, Jing/C-9666-2014
OI liu, qing song/0000-0002-7829-2547
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NR 107
TC 60
Z9 67
U1 1
U2 57
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0891-5849
EI 1873-4596
J9 FREE RADICAL BIO MED
JI Free Radic. Biol. Med.
PD JUL 15
PY 2011
VL 51
IS 2
BP 250
EP 256
DI 10.1016/j.freeradbiomed.2011.04.034
PG 7
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 787BV
UT WOS:000292352500003
PM 21569839
DA 2025-06-11
ER

PT J
AU Woodall, A
   Gampel, A
   Walker, LE
   Mair, FS
   Sheard, S
   Symon, P
   Buchan, I
AF Woodall, Alan
   Gampel, Alex
   Walker, Lauren E.
   Mair, Frances S.
   Sheard, Sally
   Symon, Pyers
   Buchan, Iain
TI Antipsychotic management in general practice: serial cross-sectional
   study (2011-2020)
SO BRITISH JOURNAL OF GENERAL PRACTICE
LA English
DT Article; Early Access
DE antipsychotics; cardiometabolic risk factors; cross- sectional studies;
   general practice; medication review; psychiatry
ID MENTAL-ILLNESS; HEALTH; MORTALITY; PEOPLE; TRENDS; CARE; EPIDEMIOLOGY;
   ENVIRONMENT; PRIVACY; DISEASE
AB Background Long- term use of antipsychotics confers increased risk of cardiometabolic disease. Ongoing need should be reviewed regularly by psychiatrists. Aim To explore trends in antipsychotic management in general practice, and the proportions of patients prescribed antipsychotics receiving psychiatrist review. Design and setting Serial cross- sectional study using linked general practice and hospital data in Wales (2011- 2020). Method Participants were adults (aged >= 18 years) registered with general practices in Wales. Outcome measures were prevalence of patients receiving >= 6 antipsychotic prescriptions annually, the proportion of patients prescribed antipsychotics receiving annual psychiatrist review, and the proportion of patients prescribed antipsychotics who were registered on the UK serious mental illness, depression, and/or dementia registers, or not on any of these registers. Results Prevalence of adults prescribed long- term antipsychotics increased from 1.055% (95% confidence interval [CI] = 1.041 to 1.069) in 2011 to 1.448% (95% CI = 1.432 to 1.464) in 2020. The proportion receiving annual psychiatrist review decreased from 59.6% (95% CI = 58.9 to 60.4) in 2011 to 52.0% (95% CI = 51.4 to 52.7) in 2020. The proportion of overall antipsychotic use prescribed to patients on the serious mental illness register decreased from 50.0% (95% CI = 49.4 to 50.7) in 2011 to 43.6% (95% CI = 43.0 to 44.1) by 2020. Conclusion Prevalence of long- term antipsychotic use is increasing. More patients are managed by GPs without psychiatrist review and are not on monitored disease registers; they thus may be less likely to undergo cardiometabolic monitoring and miss opportunities to optimise or deprescribe antipsychotics. These trends pose risks for patients and need to be addressed urgently.
C1 [Woodall, Alan] Univ Liverpool, Inst Populat Hlth, Dept Primary Care & Mental Hlth, Liverpool, England.
   [Woodall, Alan] Powys Teaching Hlth Board, Clin lead integrated care, Bronllys, Powys, Wales.
   [Gampel, Alex] Powys Teaching Hlth Board, Bronllys, Powys, Wales.
   [Walker, Lauren E.] Univ Liverpool, Ctr Expt Therapeut, Clin pharmacol & Gen internal Med, Liverpool, England.
   [Mair, Frances S.] Univ Glasgow, Sch Hlth & Wellbeing, Gen Practice & Primary Care, Glasgow, Scotland.
   [Sheard, Sally] Univ Liverpool, Inst Populat Hlth, Dept Publ Hlth Policy & Syst, Liverpool, England.
   [Symon, Pyers] Univ Liverpool, Natl Inst Hlth Care Res NIHR, Mental Hlth Res Innovat Ctr, Liverpool, England.
   [Buchan, Iain] Univ Liverpool, NIHR Mental Hlth Res Innovat Ctr, Publ Hlth Syst, Liverpool, England.
   [Buchan, Iain] Univ Liverpool, Civ Hlth Innovat Labs, Liverpool, England.
C3 University of Liverpool; University of Liverpool; University of Glasgow;
   University of Liverpool; University of Liverpool; University of
   Liverpool; University of Liverpool
RP Buchan, I (corresponding author), NIHR Mental Hlth Res Innovat Ctr, Civ Hlth Innovat Labs, Liverpool Sci Pk,131 Mt Pleasant, Liverpool L3 5TF, England.
EM buchan@liverpool.ac.uk
RI Woodall, Alan/JRW-8536-2023; Buchan, Iain/H-5767-2013; Mair, Frances
   S/JNT-6073-2023
OI Sheard, Sally/0000-0001-8116-9120; WALKER, LAUREN/0000-0002-3827-4387;
   Buchan, Iain/0000-0003-3392-1650; Woodall, Alan/0000-0003-2933-0508;
   Symon, Pyers/0009-0001-6499-8442; Mair, Frances S/0000-0001-9780-1135
FU Heath and Care Wales Research Time Award [RTA-NHS-21-02]; National
   Institute for Health and Care Research (NIHR) Senior Investigator award
   [NIHR 205131]
FX Alan Woodall is funded by a Heath and Care Wales Research Time Award
   (reference: RTA-NHS-21-02) . Iain Buchan is funded by a National
   Institute for Health and Care Research (NIHR) Senior Investigator award
   (reference: NIHR 205131) .
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NR 57
TC 2
Z9 2
U1 1
U2 1
PU ROYAL COLL GENERAL PRACTITIONERS
PI LONDON
PA 14 PRINCES GATE, HYDE PARK, LONDON SW7 1PU, ENGLAND
SN 0960-1643
EI 1478-5242
J9 BRIT J GEN PRACT
JI Br. J. Gen. Pract.
PD 2024 NOV 26
PY 2024
DI 10.3399/BJGP.2024.0367
EA NOV 2024
PG 12
WC Primary Health Care; Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA N3N2B
UT WOS:001363438700001
PM 39304310
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Johnson, RJ
   Lozada, LGS
   Lanaspa, MA
   Piani, F
   Borghi, C
AF Johnson, Richard J.
   Lozada, Laura G. Sanchez
   Lanaspa, Miguel A.
   Piani, Federica
   Borghi, Claudio
TI Uric Acid and Chronic Kidney Disease: Still More to Do
SO KIDNEY INTERNATIONAL REPORTS
LA English
DT Review
DE chronic kidney disease; gout; hyperuricemia; metabolic syndrome;
   systemic inflammation
ID URATE-LOWERING THERAPY; SMOOTH-MUSCLE-CELLS; ASYMPTOMATIC HYPERURICEMIA;
   RENAL-FUNCTION; ENDOTHELIAL DYSFUNCTION; CARDIOVASCULAR-DISEASE;
   XANTHINE-OXIDASE; OXIDATIVE STRESS; ALL-CAUSE; GOUT
AB Gout and hyperuricemia are present in 25% and 60% of patients with chronic kidney disease (CKD), respectively. Despite the common association, the role of uric acid in the progression of kidney disease and in metabolic complications remains contested. Some authorities argue that the treatment of asymptomatic hyperuricemia in CKD is not indicated, and some have even suggested hyperuricemia may be beneficial. Here, we review the various arguments both for and against treatment. The weight of the evidence suggests asymptomatic hyperuricemia is likely injurious, but it may primarily relate to sub-groups, those who have systemic crystal deposits, those with frequent urinary crystalluria or kidney stones, and those with high intracellular uric acid levels. We recommend carefully designed clinical trials to test if lowering uric acid in hyperuricemic subjects with cardiometabolic complications is protective. 2022 International Society of Nephrology. Published by Elsevier Inc. This is an open access article under the CC BY -NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
C1 [Johnson, Richard J.; Lanaspa, Miguel A.] Univ Colorado, Dept Med, Anschutz Med Campus, Aurora, CO USA.
   [Lozada, Laura G. Sanchez] Inst Nacl Cardiol Ignacio Chavez, Dept Cardiorenal Physiopathol, Mexico City, Mexico.
   [Piani, Federica; Borghi, Claudio] Univ Bologna, Dept Med & Surg Sci, Bologna, Italy.
   [Johnson, Richard J.] Univ Colorado, Div Renal Dis & Hypertens, Anschutz Med Campus,12700 East 19th Ave,RC-2 Res, Aurora, CO 80045 USA.
C3 University of Colorado System; University of Colorado Anschutz Medical
   Campus; National Institute of Cardiology - Mexico; University of
   Bologna; University of Colorado System; University of Colorado Anschutz
   Medical Campus
RP Johnson, RJ (corresponding author), Univ Colorado, Div Renal Dis & Hypertens, Anschutz Med Campus,12700 East 19th Ave,RC-2 Res, Aurora, CO 80045 USA.
EM richard.johnson@ucdenver.edu
RI Sanchez-Lozada, Laura/AAS-2104-2021; Piani, Federica/AAV-4395-2020;
   Lanaspa, Miguel/AAO-4971-2020
OI Johnson, Richard/0000-0003-3312-8193; Piani,
   Federica/0000-0003-3338-1172
FU NIH [DK121496]
FX Funding Supported in part by NIH grant DK121496.
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NR 127
TC 63
Z9 66
U1 33
U2 162
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 2468-0249
J9 KIDNEY INT REP
JI Kidney Int. Rep.
PD FEB
PY 2023
VL 8
IS 2
BP 229
EP 239
DI 10.1016/j.ekir.2022.11.016
EA FEB 2023
PG 11
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 8X1WH
UT WOS:000931809100001
PM 36815099
OA gold, Green Published
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Brandao, BB
   Poojari, A
   Rabiee, A
AF Brandao, Bruna B.
   Poojari, Ankita
   Rabiee, Atefeh
TI Thermogenic Fat: Development, Physiological Function, and Therapeutic
   Potential
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE adipose tissue; development; molecular circuits; secretome;
   thermogenesis; metabolism; obesity; therapy
ID BROWN ADIPOSE-TISSUE; ENDOPLASMIC-RETICULUM STRESS; ACTIVATED
   PROTEIN-KINASE; ENHANCES ENERGY-EXPENDITURE; FIBROBLAST GROWTH
   FACTOR-21; SYMPATHETIC-NERVOUS-SYSTEM; ESTROGEN-RELATED RECEPTORS;
   NECROSIS-FACTOR-ALPHA; DE-NOVO LIPOGENESIS; GENE-EXPRESSION
AB The concerning worldwide increase of obesity and chronic metabolic diseases, such as T2D, dyslipidemia, and cardiovascular disease, motivates further investigations into preventive and alternative therapeutic approaches. Over the past decade, there has been growing evidence that the formation and activation of thermogenic adipocytes (brown and beige) may serve as therapy to treat obesity and its associated diseases owing to its capacity to increase energy expenditure and to modulate circulating lipids and glucose levels. Thus, understanding the molecular mechanism of brown and beige adipocytes formation and activation will facilitate the development of strategies to combat metabolic disorders. Here, we provide a comprehensive overview of pathways and players involved in the development of brown and beige fat, as well as the role of thermogenic adipocytes in energy homeostasis and metabolism. Furthermore, we discuss the alterations in brown and beige adipose tissue function during obesity and explore the therapeutic potential of thermogenic activation to treat metabolic syndrome.
C1 [Brandao, Bruna B.] Harvard Med Sch, Joslin Diabet Ctr, Sect Integrat Physiol & Metab, Boston, MA 02215 USA.
   [Poojari, Ankita; Rabiee, Atefeh] Univ Pacific, Thomas J Long Sch Pharm & Hlth Sci, Dept Physiol & Pharmacol, Stockton, CA 95211 USA.
C3 Harvard University; Harvard University Medical Affiliates; Joslin
   Diabetes Center, Inc.; Harvard Medical School; University of the Pacific
RP Rabiee, A (corresponding author), Univ Pacific, Thomas J Long Sch Pharm & Hlth Sci, Dept Physiol & Pharmacol, Stockton, CA 95211 USA.
EM bruna.brasilbrandao@joslin.harvard.edu; a_poojari@u.pacific.edu;
   arabiee@pacific.edu
RI Brandao, Bruna/AAY-3939-2021; Rabiee, Atefeh/AAO-4441-2020
OI Brasil Brandao, Bruna/0000-0001-8762-6310; Poojari,
   Ankita/0000-0002-2547-5403
FU Nutting Family Foundation
FX Dr. Rabiee was partly funded by Nutting Family Foundation.
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NR 438
TC 19
Z9 21
U1 1
U2 19
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD JUN
PY 2021
VL 22
IS 11
AR 5906
DI 10.3390/ijms22115906
PG 38
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA SQ1NI
UT WOS:000660126200001
PM 34072788
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Heda, R
   Yazawa, M
   Shi, M
   Bhaskaran, M
   Aloor, FZ
   Thuluvath, PJ
   Satapathy, SK
AF Heda, Rajiv
   Yazawa, Masahiko
   Shi, Michelle
   Bhaskaran, Madhu
   Aloor, Fuad Zain
   Thuluvath, Paul J.
   Satapathy, Sanjaya K.
TI Non-alcoholic fatty liver and chronic kidney disease: Retrospect,
   introspect, and prospect
SO WORLD JOURNAL OF GASTROENTEROLOGY
LA English
DT Review
DE Nonalcoholic fatty liver disease; Chronic kidney disease; Nonalcoholic
   steatohepatitis; Organ transplant; genetic; Microbiome; Pathophysiology
ID PLACEBO-CONTROLLED TRIAL; ENDOPLASMIC-RETICULUM STRESS;
   GAMMA-GLUTAMYL-TRANSFERASE; URIC-ACID LEVELS; METABOLIC SYNDROME;
   COENZYME-Q10 SUPPLEMENTATION; RENAL-FUNCTION; DOUBLE-BLIND; INCREASED
   PREVALENCE; INSULIN-RESISTANCE
AB With the growing prevalence of obesity and diabetes in the United States and across the world, a rise in the overall incidence and prevalence of non-alcoholic fatty liver disease (NAFLD) is expected. The risk factors for NAFLD are also associated with the development of chronic kidney disease (CKD). We review the epidemiology, risk factors, genetics, implications of gut dysbiosis, and specific pathogenic mechanisms linking NAFLD to CKD. Mechanisms such as ectopic lipid accumulation, cellular signaling abnormalities, and the interplay between fructose consumption and uric acid accumulation have led to the emergence of potential therapeutic implications for this patient population. Transplant evaluation in the setting of both NAFLD and CKD is also reviewed. Potential strategies for surveillance and management include the monitoring of comorbidities, the use of non-invasive fibrosis scoring systems, and the measurement of laboratory markers. Lastly, we discuss the management of patients with NAFLD and CKD, from preventative measures to experimental interventions.
C1 [Heda, Rajiv] Tulane Univ, Dept Internal Med, Sch Med, New Orleans, LA 70112 USA.
   [Yazawa, Masahiko] St Marianna Univ, Dept Nephrol & Hypertens, Sch Med, Kawasaki, Kanagawa 2168511, Japan.
   [Shi, Michelle; Satapathy, Sanjaya K.] Northwell Hlth, Dept Internal Med, Donald & Barbara Zucker Sch Med, 400 Community Dr, Manhasset, NY 11030 USA.
   [Bhaskaran, Madhu] Northwell Hlth Zucker Sch Med Hosftra, Dept Nephrol, Manhasset, NY 11030 USA.
   [Aloor, Fuad Zain] Baylor Coll Med, Dept Internal Med, Houston, TX 77030 USA.
   [Thuluvath, Paul J.] Mercy Med Ctr, Inst Digest Hlth & Liver Dis, Baltimore, MD 21202 USA.
C3 Tulane University; Saint Marianna University; Northwell Health;
   Northwell Health; Baylor College of Medicine; Mercy Medical Center -
   Maryland
RP Satapathy, SK (corresponding author), Northwell Hlth, Dept Internal Med, Donald & Barbara Zucker Sch Med, 400 Community Dr, Manhasset, NY 11030 USA.
EM ssatapat@northwell.edu
RI Satapathy, Sanjaya/AAG-9830-2019
OI Satapathy, Sanjaya/0000-0003-0153-2829; Yazawa,
   Masahiko/0000-0002-3907-5347
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NR 147
TC 26
Z9 26
U1 1
U2 12
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 7041 Koll Center Parkway, Suite 160, PLEASANTON, CA, UNITED STATES
SN 1007-9327
EI 2219-2840
J9 WORLD J GASTROENTERO
JI World J. Gastroenterol.
PD MAY 7
PY 2021
VL 27
IS 17
BP 1864
EP 1882
DI 10.3748/wjg.v27.i17.1864
PG 19
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA SA2NV
UT WOS:000649138100002
PM 34007127
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Juanola, O
   Martínez-López, S
   Francés, R
   Gómez-Hurtado, I
AF Juanola, Oriol
   Martinez-Lopez, Sebastian
   Frances, Ruben
   Gomez-Hurtado, Isabel
TI Non-Alcoholic Fatty Liver Disease: Metabolic, Genetic, Epigenetic and
   Environmental Risk Factors
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Review
DE non-alcoholic fatty liver disease; non-alcoholic steatohepatitis;
   obesity; metabolic syndrome; type 2 diabetes mellitus
ID SUPERFAMILY MEMBER 2; ENDOPLASMIC-RETICULUM STRESS; AIRBORNE PARTICULATE
   MATTER; INSULIN-RESISTANCE; HEPATIC STEATOSIS; HEPATOCELLULAR-CARCINOMA;
   AMINOTRANSFERASE LEVELS; CONFERS SUSCEPTIBILITY; HISTOLOGICAL SEVERITY;
   FIBROSIS PROGRESSION
AB Non-alcoholic fatty liver disease (NAFLD) is one of the most frequent causes of chronic liver disease in the Western world, probably due to the growing prevalence of obesity, metabolic diseases, and exposure to some environmental agents. In certain patients, simple hepatic steatosis can progress to non-alcoholic steatohepatitis (NASH), which can sometimes lead to liver cirrhosis and its complications including hepatocellular carcinoma. Understanding the mechanisms that cause the progression of NAFLD to NASH is crucial to be able to control the advancement of the disease. The main hypothesis considers that it is due to multiple factors that act together on genetically predisposed subjects to suffer from NAFLD including insulin resistance, nutritional factors, gut microbiota, and genetic and epigenetic factors. In this article, we will discuss the epidemiology of NAFLD, and we overview several topics that influence the development of the disease from simple steatosis to liver cirrhosis and its possible complications.
C1 [Juanola, Oriol] Univ Svizzera Italiana, Ente Osped Cantonale, Translat Res Lab, Gastroenterol & Hepatol, CH-6900 Lugano, Switzerland.
   [Martinez-Lopez, Sebastian; Frances, Ruben] Miguel Hernandez Univ, Clin Med Dept, Alacant 03550, Spain.
   [Martinez-Lopez, Sebastian; Frances, Ruben; Gomez-Hurtado, Isabel] Hosp Gen Univ Alicante, Alicante Inst Hlth & Biomed Res ISABIAL, Alicante 03010, Spain.
   [Frances, Ruben; Gomez-Hurtado, Isabel] Inst Hlth Carlos III, Networked Biomed Res Ctr Hepat & Digest Dis CIBER, Madrid 28029, Spain.
C3 Universita della Svizzera Italiana; Universidad Miguel Hernandez de
   Elche; General University Hospital of Alicante; Universidad Miguel
   Hernandez de Elche; Universitat d'Alacant; Instituto de Investigacion
   Sanitaria y Biomedica de Alicante (ISABIAL); CIBER - Centro de
   Investigacion Biomedica en Red; CIBERES; CIBEREHD
RP Gómez-Hurtado, I (corresponding author), Hosp Gen Univ Alicante, Alicante Inst Hlth & Biomed Res ISABIAL, Alicante 03010, Spain.; Gómez-Hurtado, I (corresponding author), Inst Hlth Carlos III, Networked Biomed Res Ctr Hepat & Digest Dis CIBER, Madrid 28029, Spain.
EM oriol.juanola.juarez@usi.ch; sebastian.martinez@goumh.umh.es;
   frances_rub@umh.es; gomezhurtado_isa@gva.es
RI Juanola, Oriol/KUD-3025-2024; Gomez-Hurtado, Isabel/AAA-5815-2019;
   Frances, Ruben/V-4120-2019
OI Gomez-Hurtado, Isabel/0000-0003-4305-9427; Juanola,
   Oriol/0000-0001-7432-8808; Frances, Ruben/0000-0001-5105-1201; Martinez,
   Sebastian/0000-0003-1720-845X
FU Ministerio de Ciencia, Innovacion y Universidades, Madrid, Spain
   [PID2019-107036RB-I00]; Generalitat Valenciana, Valencia, Spain
   [GV/2019/141]; Asociacion Espanola para el estudio del Higado;
   Ministerio de Educacion, Ciencia y Universidades, Madrid, Spain [FPU
   19/03460]
FX This work was funded by grants PID2019-107036RB-I00 from the Ministerio
   de Ciencia, Innovacion y Universidades, Madrid, Spain and GV/2019/141
   from Generalitat Valenciana, Valencia, Spain. OJ has a post-doctoral
   fellowship from the Asociacion Espanola para el estudio del Higado. SM
   is recipient of a grant (FPU 19/03460) by Ministerio de Educacion,
   Ciencia y Universidades, Madrid, Spain.
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NR 253
TC 170
Z9 178
U1 4
U2 37
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD MAY
PY 2021
VL 18
IS 10
AR 5227
DI 10.3390/ijerph18105227
PG 24
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA SI5KJ
UT WOS:000654862800001
PM 34069012
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Lukosiute, A
   Karmali, A
   Cousins, JM
AF Lukosiute, Asta
   Karmali, Anil
   Cousins, Jonathan Mark
TI Anaesthetic Preparation of Obese Patients: Current Status on Optimal
   Work-up
SO CURRENT OBESITY REPORTS
LA English
DT Article
DE Obesity; Perioperative management of obese; Bariatric anaesthesia;
   Sleep-related breathing disorders; Metabolic syndrome; Pre-assessment of
   obese
ID OBSTRUCTIVE SLEEP-APNEA; POSITIVE AIRWAY PRESSURE; BARIATRIC SURGERY
   PRIOR; LOW-CALORIE DIET; BODY-MASS-INDEX; HYPOVENTILATION SYNDROME;
   POSTOPERATIVE OUTCOMES; STRESS ECHOCARDIOGRAPHY; KNEE ARTHROPLASTY;
   IRON-DEFICIENCY
AB With the prevalence of obesity rapidly growing, bariatric anaesthesia becomes everyday anaesthesia rather than a subspecialty. In this review, we are aiming to draw attention to this complex group of patients and their comorbidities, relevant to everyday practice for contemporary anaesthetists.
   We wanted to focus greatly on sleep-related breathing disorders, because preoperative screening, diagnosis and treatment of the aforementioned make a huge impact in the improvement of preoperative morbidity and mortality, including positive effects on the cardiovascular system. The overview is touching on main obesity-related comorbidities and guides the anaesthetist and associated health professionals on how to approach and manage them.
   A multidisciplinary approach widely used in bariatric care may be adopted in the care of obese patients in order to reduce preoperative morbidity and mortality. We advocate the early involvement of the anaesthetic team in the preoperative assessment of obese patients in order to achieve appropriate risk stratification and optimise the care.
C1 [Lukosiute, Asta; Karmali, Anil; Cousins, Jonathan Mark] St Marys Hosp, Imperial Coll Healthcare NHS Trust, London W2 1NY, England.
C3 Imperial College London
RP Lukosiute, A (corresponding author), St Marys Hosp, Imperial Coll Healthcare NHS Trust, London W2 1NY, England.
EM astalukosiu@gmail.com; anilkarmali@doctors.net.uk; johncousins@me.com
OI Lukosiute, Asta/0000-0002-1937-1667
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NR 97
TC 5
Z9 6
U1 0
U2 8
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 2162-4968
J9 CURR OBES REP
JI Curr. Obes. Rep.
PD SEP
PY 2017
VL 6
IS 3
BP 229
EP 237
DI 10.1007/s13679-017-0268-5
PG 9
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA FE8KA
UT WOS:000408452800001
PM 28707209
DA 2025-06-11
ER

PT J
AU Izquierdo-Lahuerta, A
   Martínez-García, C
   Medina-Gómez, G
AF Izquierdo-Lahuerta, Adriana
   Martinez-Garcia, Cristina
   Medina-Gomez, Gema
TI Lipotoxicity as a trigger factor of renal disease
SO JOURNAL OF NEPHROLOGY
LA English
DT Review
DE Lipotoxicity; Kidney disease; Biomarkers; miRNAs; Long non-coding RNAs
ID ADIPOSE-TISSUE EXPANDABILITY; CHRONIC KIDNEY-DISEASE; FATTY-ACID
   OXIDATION; PPAR-GAMMA; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   LIPID-METABOLISM; MESANGIAL CELLS; TGF-BETA; RECEPTOR
AB In the last few decades, rapid changes in lifestyle have led to an alarming increase in the prevalence of obesity and obesity-associated complications. Obese patients are at increased risk of developing hypertension, heart disease, insulin resistance, dyslipidemia, type 2 diabetes and kidney disease. The surplus of calories is normally stored as triglycerides in adipose tissue. However, excess lipids can also accumulate ectopically in other organs, including the kidney, contributing to their damage through toxic processes named lipotoxicity. The kidney is negatively affected by dyslipidemia, lipid accumulation and changes in circulating adipokines that bring about alterations in renal lipid metabolism and promote insulin resistance, generation of reactive oxygen species and endoplasmic reticulum stress, ultimately leading to alterations in the glomerular filtration barrier and renal failure. This review focuses on the pathogenic molecular mechanisms associated with renal lipotoxicity, and presents new insights about potential new therapeutic targets and biomarkers such as microRNAs and long non-coding RNAs, of relevance for the early detection of lipid-associated kidney disease.
C1 [Izquierdo-Lahuerta, Adriana; Martinez-Garcia, Cristina; Medina-Gomez, Gema] Univ Rey Juan Carlos, Dept Ciencias Basicas Salud, Area Bioquim & Biol Mol, Avda Atenas S-N, Madrid 28922, Spain.
C3 Universidad Rey Juan Carlos
RP Medina-Gómez, G (corresponding author), Univ Rey Juan Carlos, Dept Ciencias Basicas Salud, Area Bioquim & Biol Mol, Avda Atenas S-N, Madrid 28922, Spain.
EM gema.medina@urjc.es
RI Medina-Gomez, Gema/F-5667-2016
OI Medina-Gomez, Gema/0000-0001-8169-681X
FU Ministerio de Economia y Competitividad of Spain [BFU2012-33594,
   BFU2013-47384-R]; Comunidad de Madrid, Spain [S2010/BMD-2423]
FX This study was funded by Ministerio de Economia y Competitividad of
   Spain (BFU2012-33594, BFU2013-47384-R) and Comunidad de Madrid, Spain
   (S2010/BMD-2423).
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NR 68
TC 96
Z9 106
U1 0
U2 15
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1121-8428
EI 1724-6059
J9 J NEPHROL
JI J. Nephrol.
PD OCT
PY 2016
VL 29
IS 5
BP 603
EP 610
DI 10.1007/s40620-016-0278-5
PG 8
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA DV6AK
UT WOS:000383012600002
PM 26956132
DA 2025-06-11
ER

PT J
AU Riso, P
   Vendrame, S
   Del Bo', C
   Martini, D
   Martinetti, A
   Seregni, E
   Visioli, F
   Parolini, M
   Porrini, M
AF Riso, Patrizia
   Vendrame, Stefano
   Del Bo', Cristian
   Martini, Daniela
   Martinetti, Antonia
   Seregni, Ettore
   Visioli, Francesco
   Parolini, Marina
   Porrini, Marisa
TI Effect of 10-day broccoli consumption on inflammatory status of young
   healthy smokers
SO INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION
LA English
DT Article
DE Brassica vegetables; C-reactive protein; dietary intervention; humans;
   inflammation
ID C-REACTIVE PROTEIN; LOW-GRADE INFLAMMATION; OXIDATIVE STRESS; METABOLIC
   SYNDROME; DIETARY-INTAKE; VITAMIN-C; BRASSICA VEGETABLES;
   LIPID-PEROXIDATION; FATTY-ACIDS; DNA-DAMAGE
AB This study evaluated the effects of 10-day broccoli (250 g/day) intake on dietary markers and markers of inflammations in young male smokers. A dietary intervention study with a repeated measures crossover design was conducted. Circulating levels of carotenoids, folate, C-reactive protein (CRP), tumor necrosis factor alpha (TNF-alpha), interleukin 6 (IL-6), interleukin 6 receptor (IL-6sR) and adiponectin were measured. Broccoli intake significantly increased plasma levels of folate (+17%) and lutein (+39%), while no significant effect was observed for TNF-alpha, IL-6, IL-6sR or adiponectin. Plasma CRP decreased by 48% (post-hoc analysis, p<0.05) following broccoli diet; this resulted to be independent from the plasma variations in lutein and folate. An inverse correlation between lycopene, TNF-alpha and IL-6sR was observed at baseline. In conclusion, broccoli consumption may reduce CRP levels in smokers, consistent with epidemiologic observations that fruit and vegetable intake is associated with lower circulating CRP concentrations.
C1 [Riso, Patrizia; Vendrame, Stefano; Del Bo', Cristian; Martini, Daniela; Porrini, Marisa] Univ Milan, Dept Food Environm & Nutr Sci, Div Human Nutr, I-20133 Milan, Italy.
   [Martinetti, Antonia; Seregni, Ettore] Fdn IRCCS, Ist Nazl Tumori, Nucl Med Units, Milan, Italy.
   [Visioli, Francesco] CEI UAM CSIC, IMDEA Food, Madrid, Spain.
   [Parolini, Marina] Osped Niguarda Ca Granda, CNR Inst Clin Physiol, CardioThorac & Vasc Dept, Milan, Italy.
C3 University of Milan; Fondazione IRCCS Istituto Nazionale Tumori Milan;
   Consejo Superior de Investigaciones Cientificas (CSIC); IMDEA Food
   Institute; Consiglio Nazionale delle Ricerche (CNR); Istituto di
   Fisiologia Clinica (IFC-CNR); Ospedale Niguarda Ca' Granda; IRCCS Ca
   Granda Ospedale Maggiore Policlinico
RP Riso, P (corresponding author), Univ Milan, DeFENS Dept Food Environm & Nutr Sci, Div Human Nutr, Via Celoria 2, I-20133 Milan, Italy.
EM patrizia.riso@unimi.it
RI Martini, Daniela/S-2499-2019; Riso, Patrizia/AAC-2072-2019; Del Bò,
   Cristian/AFT-1534-2022; porrini, marisa/AAF-6788-2021; Seregni,
   Ettore/C-2597-2017; Visioli, Francesco/J-9356-2013; martini,
   daniela/D-6241-2015; Martinetti, Antonia/L-4011-2017
OI Riso, Patrizia/0000-0002-9204-7257; Seregni, Ettore/0000-0002-5097-049X;
   porrini, marisa/0000-0003-2693-3311; Visioli,
   Francesco/0000-0002-1756-1723; martini, daniela/0000-0001-8298-926X; DEL
   BO', CRISTIAN/0000-0001-7562-377X; Martinetti,
   Antonia/0000-0002-8020-7751
FU Ministry of Education, University and Research PRIN [prot. 200505819];
   Cariplo Foundation [2007.5810]
FX This work was supported by the Ministry of Education, University and
   Research PRIN 2005, prot. 200505819. Research grants were supported by
   the Cariplo Foundation [grant number 2007.5810].
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NR 43
TC 14
Z9 14
U1 2
U2 24
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0963-7486
EI 1465-3478
J9 INT J FOOD SCI NUTR
JI Int. J. Food Sci. Nutr.
PD FEB
PY 2014
VL 65
IS 1
BP 106
EP 111
DI 10.3109/09637486.2013.830084
PG 6
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA 291TE
UT WOS:000329851900016
PM 23992556
DA 2025-06-11
ER

PT J
AU Safeer, RS
   Ugalat, PS
AF Safeer, RS
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TI Cholesterol treatment guidelines update
SO AMERICAN FAMILY PHYSICIAN
LA English
DT Article
ID CORONARY-HEART-DISEASE; MYOCARDIAL-INFARCTION; SECONDARY PREVENTION;
   INSULIN-RESISTANCE; THERAPY; REDUCTION; EVENTS; WOMEN; MEN
AB Hypercholesterolemia is one of the major contributors to atherosclerosis and coronary heart disease in our society. The National Cholesterol Education Program of the National Institutes of Health has created a set of guidelines that standardize the clinical assessment and management of hypercholesterolemia for practicing physicians and other professionals in the medical community. In May 2001, the National Cholesterol Education Program released its third set of guidelines, reflecting changes in cholesterol management since their previous report in 1993. In addition to modifying current strategies of risk assessment, the new guidelines stress the importance of an aggressive therapeutic approach in the management of hypercholesterolemia. The major risk factors that modify low-density lipoprotein goals include age, smoking status, hypertension, high-density lipoprotein levels, and family history. The concept of "CHD equivalent" is introduced-conditions requiring the same vigilance used in patients with coronary heart disease. Patients with diabetes and those with a 10-year cardiac event risk of 20 percent or greater are considered CHD equivalents. Once low-density lipoprotein cholesterol is at an accepted level, physicians are advised to address the metabolic syndrome and hypertriglyceridemia.
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RP 13711 Lambertina Pl, Rockville, MD 20850 USA.
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UT WOS:000174255800008
PM 11898959
DA 2025-06-11
ER

PT J
AU Yuce, K
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AF Yuce, Kemal
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TI The kruppel-like factor (KLF) family, diseases, and physiological events
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LA English
DT Article
DE Klfs; Transcription factors; Cancer; The immune system; The
   cardiovascular system; The nervous system
ID INDUCED CARDIAC-HYPERTROPHY; CANCER CELL-PROLIFERATION; TRANSCRIPTION
   FACTOR; PANCREATIC-CANCER; TUMOR-GROWTH; LUNG-CANCER; AXON REGENERATION;
   GASTRIC-CANCER; BLOOD-CELLS; STEM-CELLS
AB The Kruppel-Like Factor family of regulatory proteins, which has 18 members, is transcription factors. This family contains zinc finger proteins, regulates the activation and suppression of transcription, and binds to DNA, RNA, and proteins. Klfs related to the immune system are Klf1, Klf2, Klf3, Klf4, Klf6, and Klf14. Klfs related to adipose tissue development and/or glucose metabolism are Klf3, Klf7, Klf9, Klf10, Klf11, Klf14, Klf15, and Klf16. Klfs related to cancer are Klf3, Klf4, Klf5, Klf6, Klf7, Klf8, Klf9, Klf10, Klf11, Klf12, Klf13, Klf14, Klf16, and Klf17. Klfs related to the cardiovascular system are Klf4, Klf5, Klf10, Klf13, Klf14, and Klf15. Klfs related to the nervous system are Klf4, Klf7, Klf8, and Klf9. Klfs are associated with diseases such as carcinogenesis, oxidative stress, diabetes, liver fibrosis, thalassemia, and the metabolic syndrome. The aim of this review is to provide information about the relationship of Klfs with some diseases and physiological events and to guide future studies.
C1 [Yuce, Kemal] Selcuk Univ, Med Fac, Dept Basic Med Sci, Physiol, Konya, Turkiye.
   [Ozkan, Ahmet Ismail] Artvin Coruh Univ, Med Aromat Plants Applicat & Res Ctr, Artvin, Turkiye.
   [Yuce, Kemal] Selcuk Univ, Med Fac, Dept Basic Med Sci, Konya, Turkiye.
C3 Selcuk University; Artvin Coruh University; Selcuk University
RP Yuce, K (corresponding author), Selcuk Univ, Med Fac, Dept Basic Med Sci, Konya, Turkiye.
EM yuce2020@hotmail.com; aiozkan@artvin.edu.tr
RI Yuce, Kemal/KQU-7394-2024; OZKAN, AHMET ISMAIL/JVM-7895-2024
OI Yuce, Kemal/0000-0001-8915-4900; OZKAN, AHMET ISMAIL/0000-0002-4511-2386
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NR 254
TC 35
Z9 38
U1 7
U2 30
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0378-1119
EI 1879-0038
J9 GENE
JI Gene
PD FEB 15
PY 2024
VL 895
AR 148027
DI 10.1016/j.gene.2023.148027
EA NOV 2023
PG 17
WC Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Genetics & Heredity
GA DB7X5
UT WOS:001129649100001
PM 38000704
DA 2025-06-11
ER

PT J
AU Zimmermann, A
AF Zimmermann, A.
TI NEW MOLECULAR AND METABOLIC ASPECTS IN ROMANIAN PATIENTS WITH CLASSIC
   21-HYDROXYLASE DEFICIENCY
SO ACTA ENDOCRINOLOGICA-BUCHAREST
LA English
DT Article
DE classic 21-hydroxylase deficiency
ID CONGENITAL ADRENAL-HYPERPLASIA; BONE-MINERAL DENSITY; STEROID
   21-HYDROXYLASE; ADULT WOMEN; PHENOTYPE; GENES; REPLACEMENT; MUTATIONS;
   GENOTYPE; DISEASE
AB 21-hydroxylase deficiency is with 90% the most frequent cause of congenital adrenal hyperplasia and is due to an inborn enzymatic defect of adrenal steroidogenesis inherited in an autosomal recessive manner.
   Here we report on the mutational spectrum of Romanian patients with classic 21-hydroxylase deficiency and describe differences to other surrounding or Latin countries. The overall genotype-phenotype correlation was 87.8%. A new mutation P94L, has been identified in a subgroup of patients with 11-beta-hydroxylase deficiency.
   Furthermore, we address the issues of early alterations in bone mineral density and metabolism as well as early discrete at in lipid and carbohydrate metabolism with enhancement of the atherogenic small dense LDL-subfraction and emerging insulin resistance. The relationship of these discrete changes to treatment variables such as the mean and cumulative hydrocortisone close stress once more the importance of an optimal glucocorticoid treatment with the lowest effective individual doses, to preclude the achievement of a suboptimal peak bone mass as well as the early appearance of traits of the metabolic syndrome.
C1 Univ Mainz Endocrinol & Metab Dis, D-55131 Mainz, Germany.
RP Zimmermann, A (corresponding author), Univ Mainz Endocrinol & Metab Dis, Langenbeckstr 1, D-55131 Mainz, Germany.
EM zimmeran@uni-mainz.de
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NR 20
TC 1
Z9 1
U1 0
U2 0
PU EDITURA ACAD ROMANE
PI BUCURESTI
PA CALEA 13 SEPTEMBRIE NR 13, SECTOR 5, BUCURESTI 050711, ROMANIA
SN 1841-0987
EI 1843-066X
J9 ACTA ENDOCRINOL-BUCH
JI Acta Endocrinol.
PD JUL-SEP
PY 2012
VL 8
IS 3
BP 471
EP 478
DI 10.4183/aeb.2012.471
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 017BU
UT WOS:000309565900013
DA 2025-06-11
ER

PT J
AU Niewöhner, J
   Döring, M
   Kontopodis, M
   Madarász, J
   Heintze, C
AF Niewoehner, Joerg
   Doering, Martin
   Kontopodis, Michalis
   Madarasz, Jeannette
   Heintze, Christoph
TI Cardiovascular Disease and Obesity Prevention in Germany: An
   Investigation into a Heterogeneous Engineering Project
SO SCIENCE TECHNOLOGY & HUMAN VALUES
LA English
DT Article
DE cardiovascular risk; prevention; heterogeneous engineering; ordering;
   overweight
ID BLOOD-BRAIN-BARRIER; METABOLIC SYNDROME; PRIMARY-CARE; OVERWEIGHT;
   STRESS; FAT; ANTHROPOLOGY; PHYSICIANS; HEALTH; RISK
AB Cardiovascular diseases present the leading cause of death worldwide. Over the last decade, their preventio has become not only a central medical and public health issue but also a matter of political concern as well as a major market for pharma, nutrition, and exercise. A preventive assemblage has formed that integrates diverse kinds of knowledges, technologies, and actors, from molecular biology to social work, to foster a specific healthy lifestyle. In this article, the authors analyze this preventive assemblage as a heterogeneous engineer, that is, as an attempt to order complex everyday life into an architecture of modernism. This article draws on research conducted as part of the interdisciplinary research cluster "preventive self" (2006-2009) bringing together analyses from social anthropology, history, linguistics, sociology of knowledge, and medicine. The authors report here primarily from ethnographic investigations into biomedical research, primary care, and educational practices in kindergartens. The authors conclude that the preventive assemblage largely fails to install any kind of singular order. Instead, it is translated into existing orderings producing heterogeneity of a different nuance.
C1 [Niewoehner, Joerg; Kontopodis, Michalis] Humboldt Univ, Dept European Ethnol, D-10117 Berlin, Germany.
   [Doering, Martin] Univ Hamburg, Forsch Schwerpunkt BIOGUM, Hamburg, Germany.
   [Madarasz, Jeannette] Social Sci Res Ctr Berlin, WZB, Berlin, Germany.
   [Heintze, Christoph] Charite, Inst Gen Med, D-13353 Berlin, Germany.
   [Niewoehner, Joerg] Humboldt Univ, Ctr Integrat Life Sci, D-10117 Berlin, Germany.
   [Doering, Martin] Univ Hamburg, Ctr Biotechnol Soc & Environm, Hamburg, Germany.
C3 Humboldt University of Berlin; University of Hamburg; Berlin Institute
   of Health; Free University of Berlin; Humboldt University of Berlin;
   Charite Universitatsmedizin Berlin; Humboldt University of Berlin;
   University of Hamburg
RP Niewöhner, J (corresponding author), Humboldt Univ, Dept European Ethnol, Mohrenstr 41, D-10117 Berlin, Germany.
EM joerg.niewoehner@staff.hu-berlin.de
RI Niewöhner, Jörg/B-5631-2013; Kontopodis, Michalis/C-8568-2013
OI Niewohner, Jorg/0000-0002-9034-9761; Kontopodis,
   Michalis/0000-0003-3948-2265; Heintze, Christoph/0000-0002-2179-8192
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NR 93
TC 13
Z9 14
U1 0
U2 9
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0162-2439
EI 1552-8251
J9 SCI TECHNOL HUM VAL
JI Sci. Technol. Hum. Values
PD SEP
PY 2011
VL 36
IS 5
SI SI
BP 723
EP 751
DI 10.1177/0162243910392797
PG 29
WC Social Issues
WE Social Science Citation Index (SSCI)
SC Social Issues
GA 823XB
UT WOS:000295159900007
DA 2025-06-11
ER

PT J
AU Peral, B
   Camafeita, E
   Fernández-Real, JM
   López, JA
AF Peral, Belen
   Camafeita, Emilio
   Fernandez-Real, Jose-Manuel
   Antonio Lopez, Juan
TI Tackling the human adipose tissue proteome to gain insight into obesity
   and related pathologies
SO EXPERT REVIEW OF PROTEOMICS
LA English
DT Review
DE 2D fluorescence difference gel electrophoresis; adipose tissue; mass
   spectrometry; metabolic syndrome; obesity; omental fat; polycystic ovary
   syndrome; proteomics; secretome; subcutaneous fat
ID POLYCYSTIC-OVARY-SYNDROME; DIFFERENCE GEL-ELECTROPHORESIS;
   CARDIOVASCULAR-DISEASE; INSULIN-RESISTANCE; STEM-CELLS;
   MASS-SPECTROMETRY; OXIDATIVE STRESS; PRIMARY CULTURES; GENE-EXPRESSION;
   ENERGY-BALANCE
AB Obesity is becoming an important public health problem given its strong association with insulin resistance and Type 2 diabetes. Previously considered an inert depot, fat is now regarded as a highly metabolically active tissue in many pathophysiological processes. In humans, the accumulation of omental rather than subcutaneous adipose tissue appears to be tightly linked to cardiovascular disease and other important comorbidities. Proteomics has emerged as a method for the large-scale study of proteins in biological samples, for instance, fluids, cells or tissues, which encompasses not only the identities of the proteins present, but also quantification and post-translational modification events. Human adipose tissue proteome analysis, still in its early stages, may help understand the molecular mechanisms of obesity and the role of omental fat in the pathogenesis of obesity-associated diseases. This review covers recent advances in human adipose tissue proteomics, focusing on the analysis of the omental and the subcutaneous fat.
C1 [Peral, Belen] CSIC, Inst Invest Biomed, E-28029 Madrid, Spain.
   [Peral, Belen] Univ Autonoma Madrid, E-28029 Madrid, Spain.
   [Camafeita, Emilio; Antonio Lopez, Juan] CNIC, Unidad Proteom, E-28029 Madrid, Spain.
   [Fernandez-Real, Jose-Manuel] Hosp Dr Josep Trueta, Dept Diabet Endocrinol & Nutr, Girona, Spain.
   [Fernandez-Real, Jose-Manuel] Hosp Dr Josep Trueta, CIBERobn Fisiopatol Obesidad & Nutr, Girona, Spain.
C3 Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Instituto
   de Investigaciones Biomedicas Alberto Sols (IIBM); Autonomous University
   of Madrid; Centro Nacional de Investigaciones Cardiovasculares (CNIC);
   Universitat de Girona; Girona University Hospital Dr. Josep Trueta;
   CIBER - Centro de Investigacion Biomedica en Red; CIBEROBN; Universitat
   de Girona; Girona University Hospital Dr. Josep Trueta
RP Peral, B (corresponding author), CSIC, Inst Invest Biomed, Arturo Duperier 4, E-28029 Madrid, Spain.
EM bperal@iib.uam.es; ecamafeita@cnic.es;
   jmfernandezreal.girona.ics@gencat.cat; jalopez@cnic.es
RI Fernández-Real, Jose Manuel/AGH-3599-2022; Lopez, Juan/JCD-9404-2023;
   PERAL, BELEN/F-4562-2015; Lopez, Juan Antonio/G-7750-2015
OI PERAL, BELEN/0000-0003-4984-4020; Lopez, Juan
   Antonio/0000-0002-9097-6060; Fernandez-Real, Jose
   Manuel/0000-0002-7442-9323
FU Ministerio de Educacion y Ciencia, Spain [SAF-2006-02354,
   SAF-2008-02073]; Ministerio de Ciencia e Innovacion and the Fundacion
   Pro CNIC
FX This work was supported by Grants SAF-2006-02354 and SAF-2008-02073 from
   the Ministerio de Educacion y Ciencia, Spain. We thank Rafael
   Perez-Perez, Eva Garcia-Santos and Francisco Ortega-Delgado for their
   technical help. The CNIC is supported by the Ministerio de Ciencia e
   Innovacion and the Fundacion Pro CNIC. CIBERobn is an initiative from
   the Instituto de Salud Carlos III. The authors have no other relevant
   affiliations or financial involvement with any organization or entity
   with a financial interest in or financial conflict with the subject
   matter or materials discussed in the manuscript apart from those
   disclosed.
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NR 55
TC 24
Z9 27
U1 0
U2 9
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1478-9450
EI 1744-8387
J9 EXPERT REV PROTEOMIC
JI Expert Rev. Proteomics
PD AUG
PY 2009
VL 6
IS 4
BP 353
EP 361
DI 10.1586/EPR.09.53
PG 9
WC Biochemical Research Methods
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 501RN
UT WOS:000270399200009
PM 19681671
OA Green Published
DA 2025-06-11
ER

PT J
AU Abu Zaid, M
   Dinh, PC
   Monahan, PO
   Fung, C
   El-Charif, O
   Feldman, DR
   Hamilton, RJ
   Vaughn, DJ
   Beard, CJ
   Cook, R
   Althouse, S
   Ardeshir-Rouhani-Fard, S
   Sesso, HD
   Huddart, R
   Mushiroda, T
   Kubo, M
   Dolan, ME
   Einhorn, LH
   Fossa, SD
   Travis, LB
AF Abu Zaid, Mohammad
   Dinh, Paul C., Jr.
   Monahan, Patrick O.
   Fung, Chunkit
   El-Charif, Omar
   Feldman, Darren R.
   Hamilton, Robert J.
   Vaughn, David J.
   Beard, Clair J.
   Cook, Ryan
   Althouse, Sandra
   Ardeshir-Rouhani-Fard, Shirin
   Sesso, Howard D.
   Huddart, Robert
   Mushiroda, Taisei
   Kubo, Michiaki
   Dolan, M. Eileen
   Einhorn, Lawrence H.
   Fossa, Sophie D.
   Travis, Lois B.
CA Platinum Study Grp
TI Adverse Health Outcomes in Relationship to Hypogonadism After
   Chemotherapy: A Multicenter Study of Testicular Cancer Survivors
SO JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK
LA English
DT Article
ID LONG-TERM SURVIVORS; INDUCED PERIPHERAL NEUROPATHY; MIDDLE-AGED MEN;
   QUALITY-OF-LIFE; METABOLIC SYNDROME; CARDIOVASCULAR-DISEASE; DYSGENESIS
   SYNDROME; TESTOSTERONE THERAPY; ANDROGEN DEFICIENCY; SERUM TESTOSTERONE
AB Background: This study examined the prevalence of hypogonadism, its clinical and genetic risk factors, and its relationship to adverse health outcomes (AHOs) in North American testicular cancer survivors (TCS) after modern platinum-based chemotherapy. Patients and Methods: Eligible TCS were <55 years of age at diagnosis and treated with first-line platinum-based chemotherapy. Participants underwent physical examinations and completed questionnaires regarding 15 AHOs and health behaviors. Hypogonadism was defined as serum testosterone levels <= 3.0 ng/mL or use of testosterone replacement therapy. We investigated the role of 2 single nucleotide polymorphisms (rs6258 and rs12150660) in the sex hormone-binding globulin (SHBG) locus implicated in increased hypogonadism risk in the general population. Results: Of 491 TCS (median age at assessment, 38.2 years; range, 18.7-68.4 years), 38.5% had hypogonadism. Multivariable binary logistic regression analysis identified hypogonadism risk factors, including age at clinical evaluation (odds ratio [OR], 1.42 per 10-year increase; P=.006) and body mass index of 25 to <30 kg/m(2) (OR, 2.08; P=.011) or >= 30 kg/m(2) (OR, 2.36; P=.005) compared with <25 kg/m(2). TCS with >= 2 risk alleles for the SHBG SNPs had a marginally significant increased hypogonadism risk (OR, 1.45; P=.09). Vigorous-intensity physical activity appeared protective (OR, 0.66; P=.07). Type of cisplatinbased chemotherapy regimen and socioeconomic factors did not correlate with hypogonadism. Compared with TCS without hypogonadism, those with hypogonadism were more likely to report >= 2 AHOs (65% vs 51%; P=.003), to take medications for hypercholesterolemia (20.1% vs 6.0%; P<.001) or hypertension (18.5% vs 10.6%; P=.013), and to report erectile dysfunction (19.6% vs 11.9%; P=.018) or peripheral neuropathy (30.7% vs 22.5%; P=.041). A marginally significant trend for increased use of prescription medications for either diabetes (5.8% vs 2.6%; P=.07) or anxiety/depression (14.8% vs 9.3%; P=.06) was observed. Conclusions: At a relatively young median age, more than one-third of TCS have hypogonadism, which is significantly associated with increased cardiovascular disease risk factors, and erectile dysfunction. Providers should screen TCS for hypogonadism and treat symptomatic patients.
C1 [Abu Zaid, Mohammad; Dinh, Paul C., Jr.; Monahan, Patrick O.; Cook, Ryan; Althouse, Sandra; Ardeshir-Rouhani-Fard, Shirin; Einhorn, Lawrence H.; Travis, Lois B.] Indiana Univ, Melvin & Bren Simon Canc Ctr, Indianapolis, IN 46202 USA.
   [Fung, Chunkit] Univ Rochester, Med Ctr, James P Wilmot Canc Inst, Rochester, NY USA.
   [El-Charif, Omar; Dolan, M. Eileen] Univ Chicago, Dept Med, 5841 S Maryland Ave, Chicago, IL 60637 USA.
   [Feldman, Darren R.] Mem Sloan Kettering Canc Ctr, Dept Med Oncol, 1275 York Ave, New York, NY 10021 USA.
   [Hamilton, Robert J.] Princess Margaret Canc Ctr, Div Urol, Toronto, ON, Canada.
   [Vaughn, David J.] Univ Penn, Dept Med, Philadelphia, PA 19104 USA.
   [Beard, Clair J.] Dana Farber Canc Inst, Dept Radiat Oncol, Boston, MA 02115 USA.
   [Sesso, Howard D.] Brigham & Womens Hosp, Dept Med, Div Prevent Med, 75 Francis St, Boston, MA 02115 USA.
   [Sesso, Howard D.] Brigham & Womens Hosp, Dept Med, Div Aging, 75 Francis St, Boston, MA 02115 USA.
   [Huddart, Robert] Royal Marsden Hosp, London, England.
   [Mushiroda, Taisei; Kubo, Michiaki] RIKEN, Ctr Integrat Med Sci, Yokohama, Kanagawa, Japan.
   [Fossa, Sophie D.] Oslo Univ Hosp, Radium Hosp, Dept Oncol, Oslo, Norway.
C3 Indiana University System; Indiana University Indianapolis; University
   of Rochester; University of Chicago; Memorial Sloan Kettering Cancer
   Center; University of Toronto; University Health Network Toronto;
   Princess Margaret Cancer Centre; University of Pennsylvania; Harvard
   University; Harvard University Medical Affiliates; Dana-Farber Cancer
   Institute; Harvard University; Harvard University Medical Affiliates;
   Brigham & Women's Hospital; Harvard University; Harvard University
   Medical Affiliates; Brigham & Women's Hospital; Royal Marsden NHS
   Foundation Trust; RIKEN; University of Oslo
RP Abu Zaid, M (corresponding author), Indiana Univ, Bone Marrow & Blood Stem Cell Transplantat, Melvin & Bren Simon Canc Ctr, 535 Barnhill Dr,RT 449, Indianapolis, IN 46202 USA.
EM mabuzaid@iu.edu
RI Abu Zaid, Mohammad/AFO-3625-2022; Dinh, Paul/HTR-1669-2023
OI Dinh, Paul/0000-0003-0235-8519; huddart, robert/0000-0003-3604-1990
FU National Cancer Institute [R01 CA157823]; National Institute of General
   Medical Sciences [U19 GM061390]
FX This study was funded by the National Cancer Institute (R01 CA157823, to
   L.B.T.) and the National Institute of General Medical Sciences (U19
   GM061390). The NCI had no role in the design of the study; the
   collection, analysis, or interpretation of data; the writing of the
   manuscript; or the decision to submit the manuscript for publication.
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NR 53
TC 16
Z9 16
U1 1
U2 5
PU HARBORSIDE PRESS
PI HUNTINGTON
PA 94 NORTH WOODHULL RD, HUNTINGTON, NY 11743 USA
SN 1540-1405
EI 1540-1413
J9 J NATL COMPR CANC NE
JI J. Natl. Compr. Cancer Netw.
PD MAY
PY 2019
VL 17
IS 5
BP 459
EP 468
DI 10.6004/jnccn.2018.7109
PG 10
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA HZ6VA
UT WOS:000468989400008
PM 31085753
OA Bronze, Green Submitted, Green Accepted
DA 2025-06-11
ER

PT J
AU Lu, G
   Liu, DM
   Xie, DN
   Lau, WB
   Liu, J
   Christopher, TA
   Lopez, B
   Liu, L
   Hu, H
   Yao, P
   He, YR
   Gao, ER
   Koch, WJ
   Zhao, JL
   Ma, XL
   Cao, Y
   Wang, YJ
AF Lu, Gan
   Liu, Demin
   Xie, Dina
   Bond Lau, Wayne
   Liu, Jing
   Christopher, Theodore A.
   Lopez, Bernard
   Liu, Lian
   Hu, Hang
   Yao, Peng
   He, Yarong
   Gao, Erhe
   Koch, Walter J.
   Zhao, Jianli
   Ma, Xin-Liang
   Cao, Yu
   Wang, Yajing
TI Ischemic Heart-Derived Small Extracellular Vesicles Impair Adipocyte
   Function
SO CIRCULATION RESEARCH
LA English
DT Article
DE adipocytes; adipokines; extracellular vesicles; homeostasis;
   transcription factors
ID ENDOPLASMIC-RETICULUM STRESS; WHITE ADIPOSE-TISSUE;
   MYOCARDIAL-INFARCTION; METABOLIC SYNDROME; MICRORNA SPONGES;
   ADIPONECTIN; EXOSOMES; CARDIOMYOCYTES; INFLAMMATION; EXPRESSION
AB Background: Patients with acute myocardial infarction suffer systemic metabolic dysfunction via incompletely understood mechanisms. Adipocytes play critical role in metabolic homeostasis. The impact of acute myocardial infarction upon adipocyte function is unclear. Small extracellular vesicles (sEVs) critically contribute to organ-organ communication. Whether and how small extracellular vesicle mediate post-MI cardiomyocyte/adipocyte communication remain unknown. Methods: Plasma sEVs were isolated from sham control (Pla-sEV(Sham)) or 3 hours after myocardial ischemia/reperfusion (Pla-sEV(MI/R)) and incubated with adipocytes for 24 hours. Compared with Pla-sEV(Sham), Pla-sEV(MI/R) significantly altered expression of genes known to be important in adipocyte function, including a well-known metabolic regulatory/cardioprotective adipokine, APN (adiponectin). Pla-sEV(MI/R) activated 2 (PERK-CHOP and ATF6 [transcription factor 6]-EDEM [ER degradation enhancing alpha-mannosidase like protein 1] pathways) of the 3 endoplasmic reticulum (ER) stress pathways in adipocytes. These pathological alterations were also observed in adipocytes treated with sEVs isolated from adult cardiomyocytes subjected to in vivo myocardial ischemia/reperfusion (MI/R) (Myo-sEV(MI/R)). Bioinformatic/RT-qPCR analysis demonstrates that the members of miR-23-27-24 cluster are significantly increased in Pla-sEV(MI/R), Myo-sEV(MI/R), and adipose tissue of MI/R animals. Administration of cardiomyocyte-specific miR-23-27-24 sponges abolished adipocyte miR-23-27-24 elevation in MI/R animals, supporting the cardiomyocyte origin of adipocyte miR-23-27-24 cluster. In similar fashion to Myo-sEV(MI/R), a miR-27a mimic activated PERK-CHOP and ATF6-EDEM-mediated ER stress. Conversely, a miR-27a inhibitor significantly attenuated Myo-sEV(MI/R)-induced ER stress and restored APN production. Results: An unbiased approach identified EDEM3 (ER degradation enhancing alpha-mannosidase like protein 3) as a novel downstream target of miR-27a. Adipocyte EDEM3 deficiency phenocopied multiple pathological alterations caused by Myo-sEV(MI/R), whereas EDEM3 overexpression attenuated Myo-sEV(MI/R)-resulted ER stress. Finally, administration of GW4869 or cardiomyocyte-specific miR-23-27-24 cluster sponges attenuated adipocyte ER stress, improved adipocyte endocrine function, and restored plasma APN levels in MI/R animals. Conclusions: We demonstrate for the first time that MI/R causes significant adipocyte ER stress and endocrine dysfunction by releasing miR-23-27-24 cluster-enriched small extracellular vesicle. Targeting small extracellular vesicle-mediated cardiomyocyte-adipocyte pathological communication may be of therapeutic potential to prevent metabolic dysfunction after MI/R.
C1 [Lu, Gan; Liu, Lian; Hu, Hang; Yao, Peng; He, Yarong; Cao, Yu] Sichuan Univ, West China Hosp, Lab Emergency Med, Dept Emergency Med, Chengdu 610041, Peoples R China.
   [Lu, Gan; Liu, Lian; Hu, Hang; Yao, Peng; He, Yarong; Cao, Yu] Sichuan Univ, West China Hosp, Natl Clin Res Ctr Geriatr, Chengdu, Peoples R China.
   [Cao, Yu] Sichuan Univ, Disaster Med Ctr, Chengdu, Peoples R China.
   [Lu, Gan; Liu, Demin; Xie, Dina; Bond Lau, Wayne; Liu, Jing; Christopher, Theodore A.; Lopez, Bernard; Yao, Peng; Zhao, Jianli; Ma, Xin-Liang; Wang, Yajing] Thomas Jefferson Univ, Dept Emergency Med, Philadelphia, PA 19107 USA.
   [Liu, Demin] Hebei Med Univ, Dept Cardiol, Shijiazhuang, Hebei, Peoples R China.
   [Gao, Erhe; Koch, Walter J.] Temple Univ, Ctr Translat Med, Philadelphia, PA 19122 USA.
C3 Sichuan University; Sichuan University; Sichuan University; Thomas
   Jefferson University; Hebei Medical University; Pennsylvania
   Commonwealth System of Higher Education (PCSHE); Temple University
RP Cao, Y (corresponding author), Sichuan Univ, West China Hosp, Lab Emergency Med, Dept Emergency Med, Chengdu 610041, Peoples R China.; Wang, YJ (corresponding author), Thomas Jefferson Univ, Dept Emergency Med, Philadelphia, PA 19107 USA.
EM wendylu1981@163.com; 1181859683@qq.com; xiedina208@outlook.com;
   Waynebond.Lau@Jefferson.edu; 1181859683@qq.com;
   theodore.christopher@jefferson.edu; Bernard.Lopez@jefferson.edu;
   1181859683@qq.com; 1282639592@qq.com; yaopengjy@163.com;
   heyarong321@163.com; erhe.gao@temple.edu; walter.koch@temple.edu;
   Jianli.zhao@jefferson.edu; xin.ma@jefferson.edu; caoyu@wchscu.cn
RI Peng, Yao/IRY-9641-2023; Koch, Walter/LKK-1594-2024; Zhao,
   Jian-Li/AEZ-5361-2022; Gan, Lu/GLU-5032-2022; Xie, Dina/JLO-9671-2023
OI Liu, Demin/0000-0002-8784-1026; Lau, Wayne Bond/0000-0002-8064-8290;
   Xie, Dina/0000-0002-2326-2041
FU National Natural Science Foundation of China [82070421, 82072135,
   81801883, 81772037]; Key R&D Project of Sichuan Provincial Department of
   Science and Technology [2021YFS0023]; 1.3.5 Project for Disciplines of
   Excellence [ZYJC18019]; Center of Excellence~International Cooperation
   Initiative Grant [139170032]; National Clinical Research Center for
   Geriatrics, West China Hospital, Sichuan University [Z20201012]
FX This work was supported by the National Natural Science Foundation of
   China (82070421, 82072135, 81801883, 81772037), Key R&D Project of
   Sichuan Provincial Department of Science and Technology (2021YFS0023),
   and supported by 1.3.5 Project for Disciplines of Excellence
   (ZYJC18019), Center of Excellence~International Cooperation Initiative
   Grant (139170032), National Clinical Research Center for Geriatrics
   (Z20201012), West China Hospital, Sichuan University.
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NR 61
TC 47
Z9 51
U1 4
U2 49
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0009-7330
EI 1524-4571
J9 CIRC RES
JI Circ.Res.
PD JAN 7
PY 2022
VL 130
IS 1
BP 48
EP 66
DI 10.1161/CIRCRESAHA.121.320157
PG 19
WC Cardiac & Cardiovascular Systems; Hematology; Peripheral Vascular
   Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Hematology
GA YC8HS
UT WOS:000739927500008
PM 34763521
OA Bronze
DA 2025-06-11
ER

PT J
AU Darmian, MA
   Hoseini, R
   Amiri, E
   Golshani, S
AF Darmian, Mahsa Ahmadi
   Hoseini, Rastegar
   Amiri, Ehsan
   Golshani, Sanam
TI Downregulated hs-CRP and MAD, upregulated GSH and TAC, and improved
   metabolic status following combined exercise and turmeric
   supplementation: a clinical trial in middle-aged women with
   hyperlipidemic type 2 diabetes
SO JOURNAL OF DIABETES AND METABOLIC DISORDERS
LA English
DT Article
DE Curcumin; Exercise; Lipids; Insulin resistance; Type 2 diabetes mellitus
ID OXIDATIVE STRESS; CURCUMA-LONGA; WEIGHT-LOSS; RESISTANCE; PLASMA;
   EXPRESSION; CAPACITY; EXTRACT; MUSCLE; TISSUE
AB Background Aerobic training (AT) and Turmeric Supplementation (TS) are known to exert multiple beneficial effects including metabolic status and Oxidative Stress. To our knowledge, data on the effects of AT and TS on metabolic status and oxidative stress biomarkers related to inflammation in subjects with Hyperlipidemic Type 2 Diabetes Mellitus (HT2DM) are scarce. Objectives This study was conducted to evaluate the effects of AT and TS on metabolic status and oxidative stress biomarkers related to inflammation in subjects with HT2DM. Methods This randomized single-blinded, placebo-controlled trial was conducted among 42 subjects with HT2DM, aged 45-60 years old. Participants were randomly assigned to four groups; AT+TS (n = 11), AT+placebo (AT; n = 10), TS (n = 11), and Control+placebo (C; n = 10). The AT program consisted of 60-75% of Maximum heart rate (HRmax), 20-40 min/day, three days/week for eight weeks. The participants in the TS group consumed three 700 mg capsules/day containing turmeric powder for eight weeks. Metabolic status and oxidative stress biomarkers were assessed at baseline and end of treatment. The data were analyzed through paired t-test and one-way analysis of variance (ANOVA) and Bonferroni post hoc test at the signification level of P < 0.05. Results After eight weeks, significant improvements were observed in metabolic status, oxidative stress biomarkers and high-sensitivity C-reactive protein (hs-CRP) in the AT+TS, TS, and AT compared to C. Additionally, a significant decrease of Metabolic Syndrome (MetS) Z scores (p = 0.001; p = 0.011), hs-CRP (p = 0.028; p = 0.041), Malondialdehyde (MAD) (p = 0.023; p = 0.001), and significantly higher Glutathione (GSH) (p = 0.003; p = 0.001), and Total Antioxidant Capacity (TAC) (p = 0.001; p = 0.001) compared to the AT and TS groups. The results also revealed a significant difference in terms of MetS Z scores (p = 0.001), hs-CRP (p = 0.018), MAD (p = 0.011), GSH (p = 0.001) and TAC (p = 0.025) between the AT and TS. Conclusions The findings suggest that AT+TS improves metabolic status, oxidative stress biomarkers, and hs-CRP more effectively compared to TS or AT in middle-aged females with T2DM and hyperlipidemia.
C1 [Darmian, Mahsa Ahmadi; Hoseini, Rastegar; Amiri, Ehsan] Razi Univ, Fac Sport Sci, Dept Exercise Physiol, 9 Taq Bostan, Kermanshah, Iran.
   [Golshani, Sanam] Kermanshah Univ Med Sci, Army Hosp 520, Kermanshah, Iran.
C3 Razi University; Kermanshah University of Medical Sciences
RP Hoseini, R (corresponding author), Razi Univ, Fac Sport Sci, Dept Exercise Physiol, 9 Taq Bostan, Kermanshah, Iran.
EM R.hoseini@razi.ac.ir
RI Amiri, Ehsan/AAA-1956-2021; Hoseini, Rastegar/ABH-7065-2020
OI Hoseini, Rastegar/0000-0001-8685-2471; Amiri, Ehsan/0000-0001-6120-9252
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NR 47
TC 14
Z9 14
U1 2
U2 7
PU SPRINGER INT PUBL AG
PI CHAM
PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND
EI 2251-6581
J9 J DIABETES METAB DIS
JI J. Diabetes Metab. Disord.
PD JUN
PY 2022
VL 21
IS 1
BP 275
EP 283
DI 10.1007/s40200-022-00970-z
EA JAN 2022
PG 9
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA 1V2OI
UT WOS:000749046700001
PM 35106289
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Ukhanova, M
   Marino, M
   Angier, H
   Jacob, L
   O'Malley, J
   Cottrell, EK
   Dambrun, K
   Heintzman, J
AF Ukhanova, Maria
   Marino, Miguel
   Angier, Heather
   Jacob, Lorie
   O'Malley, Jean
   Cottrell, Erika K.
   Dambrun, Katie
   Heintzman, John
TI The impact of capitated payment on preventive care utilization in
   community health clinics
SO PREVENTIVE MEDICINE
LA English
DT Article
DE Alternative payment model; Capitated payment model; Health policy;
   Health services; Health care systems; Oregon; Protection and affordable
   care act; Primary health care; Preventive care services
AB Only half of the United States population regularly receives recommended preventive care services. Alternative payment models (e.g., a per-member-per-month capitated payment model) may encourage the delivery of preventive services when compared to a fee-for-service visitbased model; however, evaluation is lacking in the United States. This study assesses the impact of implementing Oregon?s Alternative Payment Methodology (APM) on orders for preventive services within community health centers (CHCs). This retrospective cohort study uses electronic health record data from the OCHIN, Inc., 2012?2018, analyzed in 2018?2019. Twenty-seven CHCs which implemented APM in 2013?2016 were compared to six non-APM CHCs. Clinic-level quarterly rates of ordering nine preventive services in 2012?2018 were calculated. For each phase and preventive service, we used difference-in-differences analysis to assess the APM impact on ordering preventive care. We found greater increases for APM CHCs compared to non-APM CHCs for orders of mammograms (difference-in-differences estimates (DDs) across four phases:1.69?2.45). Both groups had decreases in ordering cervical cancer screenings, however, APM CHCs had smaller decreases (DDs:1.62?1.93). The APM CHCs had significantly greater decreases in influenza vaccinations (DDs:0.17?0.32). There were no consistent significant differences in pre-post changes in APM vs. non-APM CHCs for cardiometabolic risk screenings, smoking status and depression assessments. There was nonsignificant change in the proportion of nontraditional encounters in APM clinics compared to controls. Transition from fee-for-service to an APM did not negatively impact delivery of preventive care. Further studies are needed to understand how to change encounter structures to best deliver recommended preventive care.
C1 [Ukhanova, Maria; Marino, Miguel; Angier, Heather; Cottrell, Erika K.; Heintzman, John] Oregon Hlth & Sci Univ, Dept Family Med, Mailcode FM,3181 SW Sam Jackson Pk Rd, Portland, OR 97201 USA.
   [Marino, Miguel] Oregon Hlth & Sci Univ, Dept Publ Hlth & Prevent Med, Div Biostat, Portland, OR 97201 USA.
   [Jacob, Lorie; O'Malley, Jean; Cottrell, Erika K.; Dambrun, Katie; Heintzman, John] OCHIN Inc, Portland, OR USA.
C3 Oregon Health & Science University; Oregon Health & Science University
RP Ukhanova, M (corresponding author), Oregon Hlth & Sci Univ, Dept Family Med, Mailcode FM,3181 SW Sam Jackson Pk Rd, Portland, OR 97201 USA.
EM ukhanovaz@gmail.com
RI Ukhanova, Maria/ACN-4416-2022
OI Ukhanova, Maria/0000-0003-1143-3461
FU Agency for Healthcare Research and Quality [R01HS022651]; OCHIN, Inc.;
   Oregon Primary Care Association; Oregon Health Authority
FX This work was supported by the Agency for Healthcare Research and
   Quality (R01HS022651). We would like to acknowledge OCHIN, Inc., Oregon
   Primary Care Association, Oregon Health Authority and the participating
   APM CHCs for their support and assistance with interpreting results.
CR Abraham JM, 2014, MILBANK Q, V92, P63, DOI 10.1111/1468-0009.12041
   Alternative Payment & Advanced Care Model, 2014, ALTERNATIVE PAYMENT
   Angier H, 2017, CONTEMP CLIN TRIALS, V52, P35, DOI 10.1016/j.cct.2016.11.001
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NR 28
TC 4
Z9 4
U1 0
U2 6
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0091-7435
EI 1096-0260
J9 PREV MED
JI Prev. Med.
PD APR
PY 2021
VL 145
AR 106405
DI 10.1016/j.ypmed.2020.106405
EA JAN 2021
PG 7
WC Public, Environmental & Occupational Health; Medicine, General &
   Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; General & Internal Medicine
GA RC3HF
UT WOS:000632693900021
PM 33388331
DA 2025-06-11
ER

PT J
AU Malik, S
   Billimek, J
   Greenfield, S
   Sorkin, DH
   Ngo-Metzger, Q
   Kaplan, SH
AF Malik, Shaista
   Billimek, John
   Greenfield, Sheldon
   Sorkin, Dara H.
   Ngo-Metzger, Quyen
   Kaplan, Sherrie H.
TI Patient Complexity and Risk Factor Control Among Multimorbid Patients
   With Type 2 Diabetes Results From the R2D2C2 Study
SO MEDICAL CARE
LA English
DT Article
DE risk factors; diabetes; patient complexity; comorbidity; cardiovascular
   disease
ID CORONARY-HEART-DISEASE; LONG-TERM PERSISTENCE; ILLNESS BURDEN INDEX;
   MEDICATION NONADHERENCE; CARDIOVASCULAR-DISEASE; ADHERENCE; COMORBIDITY;
   HEALTH; HOSPITALIZATION; OUTCOMES
AB Background: Among patients with type 2 diabetes, it is not known whether risk factor control is better or worse for those who also have heart disease, depression, multiple other comorbidities, and associated management challenges.
   Objective: To examine the relationship between this complex constellation of multimorbidities, adherence to treatment and risk factor control among patients with type 2 diabetes, independent of regimen intensity.
   Research Design: Observational cross-sectional study.
   Subjects: A total of 1314 patients with diabetes from the Reducing Racial Disparities in Diabetes Coached Care (R2D2C2) Study.
   Measures: A composite cardiometabolic risk factor profile was the dependent variable. Independent variables included a composite measure of patient complexity, patient-reported adherence to treatment, history of coronary heart disease (CHD), and intensity of medication regimen.
   Results: A higher proportion of the most complex patient-reported problems with adherence compared with the least complex patients (83.5% vs. 43.3%, P <0.001). Compared with those without a history of CHD, fewer patients with CHD-reported problems with medication adherence (59.3% vs. 69.3%, P <0.01) and had better risk factor control, independent of complexity and regimen intensity. Better risk factor control was independently associated with less patient complexity (P = 0.003) and to history of CHD (P = 0.01).
   Conclusions: The presence of a complex illness profile was associated with poorer control of risk factors. Those with CHD were more adherent to treatment and had better risk factor control. The occurrence of CHD may present an opportunity for physicians to emphasize risk factor management. Diabetes patients with a complex illness profile may be at highest risk for cardiovascular events and in greatest need of prevention of cardiac disease.
C1 [Malik, Shaista] Univ Calif Irvine, Dept Med, Div Cardiol, Irvine, CA 92868 USA.
   [Billimek, John; Greenfield, Sheldon; Sorkin, Dara H.; Kaplan, Sherrie H.] Univ Calif Irvine, Dept Med, Hlth Policy Res Inst, Irvine, CA 92868 USA.
   [Ngo-Metzger, Quyen] Bur Primary Hlth Care, Off Qual & Data, Hlth Resources & Serv Adm, US Dept HHS, Rockville, MD USA.
C3 University of California System; University of California Irvine;
   University of California System; University of California Irvine; United
   States Health Resources & Service Administration (HRSA)
RP Malik, S (corresponding author), Univ Calif Irvine, Dept Med, Div Cardiol, 333 City Blvd W,Suite 400, Irvine, CA 92868 USA.
EM smalik@uci.edu
OI Greenfield, Sheldon/0000-0003-4628-1998; Kaplan,
   Sherrie/0000-0002-8644-5849
FU National Institute of Diabetes, Digestive and Kidney Diseases
   [R18DK69846, K01DK078939]; Robert Wood Johnson Foundation [1051084,
   59758]; NovoNordisk Foundation; Lilly Research Laboratories
FX Supported by the National Institute of Diabetes, Digestive and Kidney
   Diseases (R18DK69846 and K01DK078939), the Robert Wood Johnson
   Foundation (Generalist Physician Faculty Award #1051084 and Finding
   Answers: Disparities Research for Change #59758), the NovoNordisk
   Foundation, and Lilly Research Laboratories. S. M., J.B., S. G., D. H.
   S., Q.N.M., and S. H. K. had full access to the data in the study and
   take responsibility for the integrity of the data and accuracy of the
   data analysis. S. G. and S. H. K. received funding for research grants
   from Lilly Research Laboratories and NovoNordisk Foundation (modest). S.
   M. received funding for research grant from Lilly Research Laboratories.
   The authors declare no conflict of interest.
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NR 34
TC 12
Z9 13
U1 0
U2 12
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7079
EI 1537-1948
J9 MED CARE
JI Med. Care
PD FEB
PY 2013
VL 51
IS 2
BP 180
EP 185
DI 10.1097/MLR.0b013e318273119b
PG 6
WC Health Care Sciences & Services; Health Policy & Services; Public,
   Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services; Public, Environmental & Occupational
   Health
GA 078LW
UT WOS:000314101400011
PM 23047130
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Meepring, S
   Gray, R
   Li, Y
   Ho, G
   Chien, WT
   Bressington, D
AF Meepring, Soontareeporn
   Gray, Richard
   Li, Yan
   Ho, Grace
   Chien, Wai-Tong
   Bressington, Daniel
TI Cardiometabolic health risks, lifestyle behaviours and quality of life
   in people diagnosed with early psychosis - A cross-sectional study
SO JOURNAL OF PSYCHIATRIC AND MENTAL HEALTH NURSING
LA English
DT Article
DE cardiovascular disease risk; early psychosis; lifestyle behaviours;
   quality of life
ID INDUCED WEIGHT-GAIN; BODY-MASS INDEX; METABOLIC SYNDROME; PHYSICAL
   HEALTH; WHOQOL-BREF; CARDIOVASCULAR-DISEASE; SCHIZOPHRENIA; PREVALENCE;
   INTERVENTION; METAANALYSIS
AB Accessible summary What is known on the subject? People diagnosed with schizophrenia have poor cardiometabolic health, with elevated 10-year cardiovascular disease risk (CVD-R) scores and low quality of life (QOL). There is a lack of understanding about CVD-R scores in people diagnosed with early psychosis and no studies have quantified CVD-R using the QRISK(R)3 calculator in this client group. Establishing potential relationships between modifiable lifestyle behaviours/treatment characteristics with CVD-R or QOL may identify targets for early intervention. What the paper adds to existing knowledge? This is the first study to quantify the individual 10-year CVD-R of people diagnosed with early psychosis utilising the QRISK(R)3 calculator. This is also the first study to investigate relationships between QOL and CVD-R and lifestyle factors in a cohort of Thai people diagnosed with early psychosis. We observed low levels of physical health-related QOL and high levels of CVR-R despite participants reporting relatively positive lifestyle behaviours. What are the implications for practice? The cardiometabolic health state of this client group warrants as much attention as for those with an enduring severe mental illness; early preventative interventions are warranted. It may be useful to routinely quantify the CVD-R of people diagnosed with early psychosis using the QRISK(R)3 calculator, even in the absence of immediate concerns about lifestyle behaviours. Mental health nurses should utilise evidence-based approaches such as increasing activity levels, dietary counselling and behaviour change interventions to mitigate poor physical health in this client group. Introduction People diagnosed with schizophrenia have poor cardiometabolic health, with elevated 10-year cardiovascular disease risk (CVD-R) scores and poor quality of life (QOL). There is lack of understanding of these issues in early psychosis. Aims To quantify CVD-R in people diagnosed with early psychosis and profile their obesity prevalence, lifestyle behaviours and QOL. Secondary aim was to explore associations between lifestyle behaviours/treatment characteristics and CVD-R/QOL. Method Baseline data from 81 RCT participants were used to profile cardiometabolic health risks (QRISK(R)3, BMI and waist circumference). Participants self-reported lifestyle behaviours and QOL. Relationships between modifiable treatment/lifestyle factors and QOL/CVD-R were explored. Results Participants' relative risk for CVD over 10 years was 1.93 times higher than healthy counterparts; 39% also had an obese BMI and physical QOL was poor. No significant associations were observed between CVD-R or QOL with treatment characteristics and lifestyle factors. Discussion Despite positive lifestyle behaviours, participants had elevated CVD-R scores and poor physical health-related QOL. Quantifying CVD-R with QRISK(R)3 may highlight the need for health promotion interventions. Implications for practice Mental health professionals should be aware that elevated CVD-R exists in the context of relatively healthy lifestyle behaviours and utilise evidence-based interventions to address these issues.
C1 [Meepring, Soontareeporn] Naresuan Univ, Phitsanulok, Thailand.
   [Gray, Richard] La Trobe Univ, Melbourne, Vic, Australia.
   [Li, Yan; Ho, Grace] Hong Kong Polytech Univ, Hong Kong, Peoples R China.
   [Chien, Wai-Tong] Chinese Univ Hong Kong, Hong Kong, Peoples R China.
   [Bressington, Daniel] Charles Darwin Univ, Darwin, NT, Australia.
C3 Naresuan University; La Trobe University; Hong Kong Polytechnic
   University; Chinese University of Hong Kong; Charles Darwin University
RP Bressington, D (corresponding author), Charles Darwin Univ, Coll Nursing & Midwifery, Darwin, NT, Australia.
EM daniel.bressington@cdu.edu.au
RI Chien, Wai Tong/M-6106-2019; HO, Grace/AAY-3410-2021; Bressington,
   Daniel/G-2789-2017; Gray, Richard/C-9945-2017; Chien, Wai
   Tong/F-9604-2014; HO, Grace Wing Ka/G-3246-2017
OI LI, Yan/0000-0002-5311-9190; Bressington, Daniel/0000-0003-0951-2208;
   Gray, Richard/0000-0001-9694-4206; Chien, Wai Tong/0000-0001-5321-5791;
   HO, Grace Wing Ka/0000-0003-4703-5430
FU Thailand Research Fund; Office of The Higher Education Commission, Royal
   Thai Government [MRG6080216]
FX This study was supported by a research grant from The Thailand Research
   Fund and the Office of The Higher Education Commission, Royal Thai
   Government, contract No. MRG6080216
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NR 62
TC 3
Z9 4
U1 1
U2 14
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1351-0126
EI 1365-2850
J9 J PSYCHIATR MENT HLT
JI J. Psychiatr. Ment. Health Nurs.
PD AUG
PY 2022
VL 29
IS 4
BP 578
EP 591
DI 10.1111/jpm.12809
EA DEC 2021
PG 14
WC Nursing; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Psychiatry
GA 2W5OU
UT WOS:000730328200001
PM 34854171
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Audureau, E
   Pouchot, J
   Coste, J
AF Audureau, Etienne
   Pouchot, Jacques
   Coste, Joel
TI Gender-Related Differential Effects of Obesity on Health-Related Quality
   of Life via Obesity-Related Comorbidities A Mediation Analysis of a
   French Nationwide Survey
SO CIRCULATION-CARDIOVASCULAR QUALITY AND OUTCOMES
LA English
DT Article
DE gender differences; health-related quality of life; obesity; population
   studies; women
ID BODY-MASS INDEX; OVERWEIGHT; WEIGHT; IMPACT; ADULTS; SF-36; PAIN;
   ASSOCIATIONS; DEPRESSION; MORTALITY
AB Background-Negative effects of obesity on health-related quality of life (HRQoL) have been reported, especially in women, but the relative contribution of cardiometabolic and other obesity-related comorbidities to such effects remains unclear. Our objective was to model the association by sex between body mass index and HRQoL and to precisely quantify the indirect effects mediated by obesity-related comorbidities.
   Methods and Results-Data were drawn from the latest French Decennial Health Survey, a nationwide cross-sectional study conducted in 2003 (21 239 adults aged 25-64 years analyzed). HRQoL was measured by the 36-item short-form health survey questionnaire. A mediation analysis based on the counterfactual framework was performed to quantify the proportion of obesity effects on HRQoL mediated by related comorbidities, including cardiometabolic risk factors (diabetes mellitus, hypertension, dyslipidemia) and diseases (ischemic heart disease, cerebrovascular, and peripheral vascular disease), musculoskeletal disorders, and asthma. After multiple linear regression, inverse associations were found between increasing body mass index category and physically oriented and most mentally oriented 36-item short-form health survey dimensions, with evidence of greater effects in women. Mediation analysis revealed that obesity effects were significantly mediated by several comorbidities, more apparently in men (eg, proportion of obesity class II total effect mediated via cardiometabolic factors: general health 27.0% [men] versus 13.6% [women]; proportion of obesity class II total effect mediated via total count of comorbidities: physical functioning 17.8% [men] versus 7.7% [women] and general health 37.1% [men] versus 20.3% [women]).
   Conclusions-Women have a greater overall impact of obesity on HRQoL, but with proportionally lower effects mediated by cardiometabolic and other obesity-related conditions, suggesting the possible role of other specific psychosocial processes.
C1 [Audureau, Etienne; Coste, Joel] Hop Hotel Dieu, AP HP, Biostat & Epidemiol Unit, Paris, France.
   [Audureau, Etienne; Pouchot, Jacques; Coste, Joel] Univ Lorraine, Res Unit APEMAC, EA 4360, Univ Paris Descartes,Sorbonne Paris Cite, Nancy, France.
   [Pouchot, Jacques] Hop Europeen Georges Pompidou, AP HP, Dept Internal Med, Paris, France.
C3 Assistance Publique Hopitaux Paris (APHP); Universite Paris Cite;
   Hopital Universitaire Hotel-Dieu - APHP; Universite de Lorraine;
   Universite Paris Cite; Assistance Publique Hopitaux Paris (APHP);
   Universite Paris Cite; Hopital Universitaire Europeen Georges-Pompidou -
   APHP
RP Audureau, E (corresponding author), Hop Henri Mondor, Serv Sante Publ, 51 Ave Marechal Lattre de Tassigny, F-94010 Creteil, France.
EM etienne.audureau@gmail.com
RI Audureau, Etienne/R-4359-2018
OI Audureau, Etienne/0000-0002-6166-149X
FU National Institute for Statistics and Economic Studies
FX The Decennial Health Survey was funded and performed by the National
   Institute for Statistics and Economic Studies. The funding source had no
   role in the present analysis, article preparation, interpretation, or
   decision to submit the article for publication.
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NR 54
TC 37
Z9 37
U1 0
U2 12
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1941-7705
EI 1941-7713
J9 CIRC-CARDIOVASC QUAL
JI Circ.-Cardiovasc. Qual. Outcomes
PD MAY
PY 2016
VL 9
IS 3
BP 246
EP +
DI 10.1161/CIRCOUTCOMES.115.002127
PG 17
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Cardiovascular System & Cardiology
GA DN0JQ
UT WOS:000376750600009
PM 27166204
OA Bronze
DA 2025-06-11
ER

PT J
AU Bahrami, S
   Steen, NE
   Shadrin, A
   O'Connell, K
   Frei, O
   Bettella, F
   Wirgenes, KV
   Krull, F
   Fan, CC
   Dale, AM
   Smeland, OB
   Djurovic, S
   Andreassen, OA
AF Bahrami, Shahram
   Steen, Nils Eiel
   Shadrin, Alexey
   O'Connell, Kevin
   Frei, Oleksandr
   Bettella, Francesco
   Wirgenes, Katrine V.
   Krull, Florian
   Fan, Chun C.
   Dale, Anders M.
   Smeland, Olav B.
   Djurovic, Srdjan
   Andreassen, Ole A.
TI Shared Genetic Loci Between Body Mass Index and Major Psychiatric
   Disorders A Genome-wide Association Study
SO JAMA PSYCHIATRY
LA English
DT Article
ID BIPOLAR DISORDER; BLOOD-PRESSURE; SCHIZOPHRENIA; OBESITY; RISK;
   DEPRESSION; VARIANTS; PLEIOTROPY; IDENTIFICATION; METAANALYSIS
AB Importance People with major psychiatric disorders (MPDs) have a 10- to 20-year shorter life span than the rest of the population, and this difference is mainly due to comorbid cardiovascular diseases. Genome-wide association studies have identified common variants involved in schizophrenia (SCZ), bipolar disorder (BIP), and major depression (MD) and body mass index (BMI), a key cardiometabolic risk factor. However, genetic variants jointly influencing MPD and BMI remain largely unknown.
   Objective To assess the extent of the overlap between the genetic architectures of MPDs and BMI and identify genetic loci shared between them.
   Design, Setting, and Participants Using a conditional false discovery rate statistical framework, independent genome-wide association study data on individuals with SCZ (n = 82 315), BIP (n = 51 710), MD (n = 480 359), and BMI (n = 795 640) were analyzed. The UK Biobank cohort (n = 29 740) was excluded from the MD data set to avoid sample overlap. Data were collected from August 2017 to May 2018, and analysis began July 2018.
   Main Outcomes and Measures The primary outcomes were a list of genetic loci shared between BMI and MPDs and their functional pathways.
   Results Genome-wide association study data from 1 380 284 participants were analyzed, and the genetic correlation between BMI and MPDs varied (SCZ: r for genetic = -0.11, P = 2.1 x 10(-10); BIP: r for genetic = -0.06, P = .0103; MD: r for genetic = 0.12, P = 6.7 x 10(-10)). Overall, 63, 17, and 32 loci shared between BMI and SCZ, BIP, and MD, respectively, were analyzed at conjunctional false discovery rate less than 0.01. Of the shared loci, 34% (73 of 213) in SCZ, 52% (36 of 69) in BIP, and 57% (56 of 99) in MD had risk alleles associated with higher BMI (conjunctional false discovery rate <0.05), while the rest had opposite directions of associations. Functional analyses indicated that the overlapping loci are involved in several pathways including neurodevelopment, neurotransmitter signaling, and intracellular processes, and the loci with concordant and opposite association directions pointed mostly to different pathways.
   Conclusions and Relevance In this genome-wide association study, extensive polygenic overlap between BMI and SCZ, BIP, and MD were found, and 111 shared genetic loci were identified, implicating novel functional mechanisms. There was mixture of association directions in SCZ and BMI, albeit with a preponderance of discordant ones.
C1 [Bahrami, Shahram; Steen, Nils Eiel; Shadrin, Alexey; O'Connell, Kevin; Frei, Oleksandr; Bettella, Francesco; Krull, Florian; Smeland, Olav B.; Andreassen, Ole A.] Univ Oslo, NORMENT Ctr, Inst Clin Med, Oslo, Norway.
   [Bahrami, Shahram; Steen, Nils Eiel; Shadrin, Alexey; O'Connell, Kevin; Frei, Oleksandr; Bettella, Francesco; Krull, Florian; Smeland, Olav B.; Andreassen, Ole A.] Oslo Univ Hosp, Div Mental Hlth & Addict, Oslo, Norway.
   [Wirgenes, Katrine V.; Djurovic, Srdjan] Oslo Univ Hosp, Dept Med Genet, Oslo, Norway.
   [Fan, Chun C.; Dale, Anders M.] Univ Calif San Diego, Dept Radiol, La Jolla, CA 92093 USA.
   [Fan, Chun C.] Univ Calif San Diego, Dept Cognit Sci, La Jolla, CA 92093 USA.
   [Dale, Anders M.] Univ Calif San Diego, Multimodal Imaging Lab, La Jolla, CA 92093 USA.
   [Dale, Anders M.] Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA.
   [Dale, Anders M.] Univ Calif San Diego, Dept Neurosci, La Jolla, CA 92093 USA.
   [Djurovic, Srdjan] Univ Bergen, Dept Clin Sci, NORMENT Ctr, Bergen, Norway.
C3 University of Oslo; University of Oslo; University of Oslo; University
   of California System; University of California San Diego; University of
   California System; University of California San Diego; University of
   California System; University of California San Diego; University of
   California System; University of California San Diego; University of
   California System; University of California San Diego; University of
   Bergen
RP Bahrami, S (corresponding author), Univ Oslo, Univ Sykehus HF Ulleval Avdeling Psykoseforskning, Bygg 49, N-0424 Oslo, Norway.; Andreassen, OA (corresponding author), NORMENT, Psychiat, Irkeveien 166, N-0407 Oslo, Norway.
EM shahram.bahrami@medisin.uio.no; o.a.andreassen@medisin.uio.no
RI Dinan, Timothy/ABA-8284-2020; Steen, Nils Eiel/GRO-6284-2022; Fan, Chun
   Chieh/JDC-7329-2023; Andreassen, Ole/AAY-7531-2020; Smeland,
   Olav/AAM-5284-2020
OI Smeland, Olav Bjerkehagen/0000-0002-3761-5215; Frei,
   Oleksandr/0000-0002-6427-2625
FU National Institutes of Health [NS057198, EB00790]; Research Council of
   Norway [229129, 213837, 223273]; South-Eastern Norway Regional Health
   Authority [2017-112]; Kristian Gerhard Jebsen Foundation [SKGJ-MED-008]
FX We gratefully acknowledge support from the National Institutes of Health
   (grants NS057198 and EB00790), the Research Council of Norway (grants
   229129, 213837, and 223273), the South-Eastern Norway Regional Health
   Authority (grant 2017-112), and Kristian Gerhard Jebsen Foundation
   (grant SKGJ-MED-008).
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NR 73
TC 84
Z9 86
U1 1
U2 11
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 2168-622X
EI 2168-6238
J9 JAMA PSYCHIAT
JI JAMA Psychiatry
PD MAY
PY 2020
VL 77
IS 5
BP 503
EP 512
DI 10.1001/jamapsychiatry.2019.4188
PG 10
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA LP0VU
UT WOS:000534040500012
PM 31913414
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Chimenti, C
   Sale, P
   Verardo, R
   Cicalini, S
   Petrosillo, N
   Russo, MA
   Fedele, F
   Frustaci, A
AF Chimenti, Cristina
   Sale, Patrizio
   Verardo, Romina
   Cicalini, Stefania
   Petrosillo, Nicola
   Russo, Matteo A.
   Fedele, Francesco
   Frustaci, Andrea
TI High prevalence of intramural coronary infection in patients with
   drug-resistant cardiac syndrome X: comparison with chronic stable angina
   and normal controls
SO HEART
LA English
DT Article
ID C-REACTIVE PROTEIN; INFLAMMATORY CARDIOMYOPATHY; MYOCARDIAL-ISCHEMIA;
   VIRAL-INFECTIONS; ARTERY-DISEASE; CHEST-PAIN; STRESS; DYSFUNCTION;
   ANGIOGRAMS; PECTORIS
AB Background Coronary microvascular dysfunction has been reported along with myocardial viral infection. Whether intramural coronary vessels infection plays a role in patients with cardiac syndrome X (CSX) is unknown.
   Methods Thirteen consecutive patients (four men, nine women, mean age 51 +/- 10.5 years) with drug-resistant CSX underwent left ventricular endomyocardial biopsy. Myocardial tissue was examined for histology, immunohistochemistry and for the presence of cardiotropic viruses by PCR analysis. In the presence of a viral infection on the whole tissue, laser microdissection was performed to analyse the viral genome selectively in intramural vessels and cardiomyocytes. Controls were surgical cardiac biopsies from patients with chronic stable angina and from patients with mitral stenosis and normal cardiac function (normal controls).
   Results Histology showed hypertrophy and degeneration of cardiomyocytes with interstitial and replacement fibrosis in all CSX, while focal lymphocytic myocarditis was additionally recognised in three patients. No vasculitis was observed. Viral genomes were detected in nine of 13 CSX (Epstein-Barr virus in four, adenovirus in three, human herpes virus (HHV) 6 in one, Epstein-Barr adenovirus co-infection in one). Laser microdissection showed that Epstein-Barr and adenovirus localised both in cardiomyocytes and intramural vessels, while HHV-6 infection was confined to the vessel wall.
   Conclusions Viral genomes can be detected in intramural vessels of up to 69% of drug-resistant CSX. Coronary small vessels infection represents an alternative pathophysiological mechanism of this syndrome and can explain the poor response to anti-ischaemic drugs.
C1 [Chimenti, Cristina; Fedele, Francesco; Frustaci, Andrea] Univ Roma La Sapienza, Cardiovasc & Resp Sci Dept, I-00161 Rome, Italy.
   [Chimenti, Cristina; Verardo, Romina; Frustaci, Andrea] IRCCS Lazzaro Spallanzani, Mol & Cellular Cardiol Lab, Rome, Italy.
   [Chimenti, Cristina; Sale, Patrizio; Russo, Matteo A.] Univ Roma La Sapienza, Expt Med & Pathol Dept, I-00161 Rome, Italy.
   [Sale, Patrizio; Russo, Matteo A.] IRCCS San Raffaele La Pisana, Rome, Italy.
   [Cicalini, Stefania; Petrosillo, Nicola] IRCCS L Spallanzani, Infect Dis Unit 2, Rome, Italy.
C3 Sapienza University Rome; IRCCS Lazzaro Spallanzani; Sapienza University
   Rome; IRCCS San Raffaele Pisana; IRCCS Lazzaro Spallanzani
RP Frustaci, A (corresponding author), Univ Roma La Sapienza, Cardiovasc & Resp Sci Dept, Viale Policlin 155, I-00161 Rome, Italy.
EM biocard@inmi.it
RI Petrosillo, Nicola/AAZ-2095-2021; Verardo, Romina/LRV-1647-2024; Russo,
   Matteo/AAD-7733-2021; Fedele, Francesco/J-7651-2012; Chimenti,
   Cristina/AAC-2437-2019; Sale, Patrizio/K-8757-2016
OI petrosillo, nicola/0000-0002-2585-7567; Sale,
   Patrizio/0000-0002-4850-3673; Verardo, Romina/0000-0001-5542-567X
FU EX ART.56
FX This study was funded by grant EX ART.56 entitled 'HIV-related and
   unrelated inflammatory cardiomyopathy: identification of causal agents
   and pathogenetic mechanisms providing a tailored therapy'.
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NR 30
TC 9
Z9 9
U1 0
U2 0
PU B M J PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 1355-6037
J9 HEART
JI Heart
PD DEC
PY 2010
VL 96
IS 23
BP 1926
EP 1931
DI 10.1136/hrt.2010.196626
PG 6
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 677LZ
UT WOS:000283995200014
PM 20889988
DA 2025-06-11
ER

PT J
AU Mashiba, J
   Koike, G
   Kamiunten, H
   Ikeda, M
   Sunagawa, K
AF Mashiba, J
   Koike, G
   Kamiunten, H
   Ikeda, M
   Sunagawa, K
TI Vasospastic angina and microvascular angina are differentially
   influenced by PON1 A632G polymorphism in the Japanese
SO CIRCULATION JOURNAL
LA English
DT Article
DE coronary vasospasm; oxidative stress; polymorphism; PON1 (paraoxonase 1
   gene); smoking
ID CORONARY SPASTIC ANGINA; ACTIVATING-FACTOR-ACETYLHYDROLASE;
   LOW-DENSITY-LIPOPROTEIN; NEUTROPHIL CYTOCHROME-B; POSTMENOPAUSAL WOMEN;
   ARTERY SPASM; MYOCARDIAL-INFARCTION; VASOMOTOR REACTIVITY; LIGHT CHAIN;
   SYNDROME-X
AB Background Ethnicity and smoking are well-known risk factors for the pathogenesis of coronary vasospasm. Oxidative stress induced by smoking plays a crucial role in coronary vasospasm, but is not enough to account for the pathogenesis of coronary vasospasm, indicating that genetic factors are strongly involved.
   Methods and Results The study group comprised 162 vasospastic angina patients (VSAs), 61 microvascular angina patients (MVAs) and 61 non-responders (NRs) diagnosed by acetylcholine provocation test. Four polymorphisms of the oxidative stress related genes, cytochrome b-245, alpha polypeptide gene (CYBA) C242T and A640G, paraoxonase 1 gene (PON1) A632G, phospholipase A2 group VII gene (PLA2G7) G994T were genotyped. Allele frequency of PON1 632-G was significantly higher in both the VSA with dominant fashion and the MVA with recessive fashion compared with NR. This association was strongly influenced by gender in the MVA only. There were no significant associations between the other polymorphisms and coronary vasospasm. In addition, the allele frequency of PON1 632-G in the Japanese was higher than in Caucasians.
   Conclusions There was a significant association between PON1 A632G polymorphism and MVA as well as VSA, but the impact of this on VSA and MVA is different in the Japanese.
C1 Kyushu Univ, Grad Sch Med Sci, Dept Cardiovasc Med, Higashi Ku, Fukuoka 8128582, Japan.
C3 Kyushu University
RP Kyushu Univ, Grad Sch Med Sci, Dept Cardiovasc Med, Higashi Ku, 3-1-1 Maidashi, Fukuoka 8128582, Japan.
EM koike@cardiol.med.kyushu-u.ac.jp
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NR 46
TC 20
Z9 20
U1 0
U2 0
PU JAPANESE CIRCULATION SOC
PI TOYKO
PA 18TH FLOOR IMPERIAL HOTEL TOWER, 1-1-1 UCHISAIWAI-CHO CHIYODA-KU, TOYKO,
   100-0011, JAPAN
SN 1346-9843
EI 1347-4820
J9 CIRC J
JI Circ. J.
PD DEC
PY 2005
VL 69
IS 12
BP 1466
EP 1471
DI 10.1253/circj.69.1466
PG 6
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 988SF
UT WOS:000233620300005
PM 16308493
OA Bronze
DA 2025-06-11
ER

PT J
AU Huang, SS
   Huang, PH
   Leu, HB
   Wu, TC
   Lin, SJ
   Chen, JW
AF Huang, Shao-Sung
   Huang, Po-Hsun
   Leu, Hsin-Bang
   Wu, Tao-Cheng
   Lin, Shing-Jong
   Chen, Jaw-Wen
TI Serum bilirubin predicts long-term clinical outcomes in patients with
   cardiac syndrome X
SO HEART
LA English
DT Article
ID NORMAL CORONARY ANGIOGRAMS; ALBUMIN-BOUND BILIRUBIN; ARTERY-DISEASE;
   ANGINA-PECTORIS; INCREASED RISK; CHEST-PAIN; ANTIOXIDANT; DYSFUNCTION;
   INFLAMMATION; INDUCTION
AB Background Increased oxidative stress and vascular inflammation have been demonstrated in patients with cardiac syndrome X (CSX). Bilirubin, once considered simply the metabolic end product of haem degradation, has emerged as a potential endogenous inhibitor of atherosclerosis. This study was conducted to evaluate the prognostic role of serum bilirubin in disease progression and clinical outcome in patients with CSX.
   Methods A total of 108 consecutive CSX patients were enrolled. Serum bilirubin levels were examined from blood samples collected before coronary angiography. All patients were prospectively followed up for 5 years for the composite end point of total adverse events including death and non-fatal cardiovascular events (non-fatal myocardial infarction, ischaemic stroke, rehospitalisation for unstable angina, and coronary revascularisation).
   Results There were 20 adverse events, including five deaths, five ischaemic strokes and 10 rehospitalisations for unstable angina during follow-up. Patients with adverse events had lower baseline serum bilirubin levels (p<0.001). All patients were stratified into high-bilirubin, normal-bilirubin and low-bilirubin groups. The patients in the high-bilirubin group had the lowest incidence of total adverse events (p=0.008) and non-fatal cardiovascular events (p=0.008). In a multivariate Cox regression analysis, serum bilirubin, in addition to age and basal superoxide generation of circulating mononuclear cells, was also an independent predictor of total adverse events (HR 0.002; 95% CI 0.000 to 0.520; p=0.028).
   Conclusions In patients with CSX, baseline serum bilirubin level was associated with long-term outcomes. Serum bilirubin could be a predictive and protective biomarker for disease progression and the development of cardiovascular events in CSX patients.
C1 [Huang, Shao-Sung; Huang, Po-Hsun; Leu, Hsin-Bang; Wu, Tao-Cheng; Lin, Shing-Jong; Chen, Jaw-Wen] Taipei Vet Gen Hosp, Div Cardiol, Dept Internal Med, Taipei, Taiwan.
   [Huang, Shao-Sung; Huang, Po-Hsun; Leu, Hsin-Bang; Wu, Tao-Cheng; Lin, Shing-Jong; Chen, Jaw-Wen] Natl Yang Ming Univ, Cardiovasc Res Ctr, Taipei 112, Taiwan.
   [Huang, Po-Hsun; Leu, Hsin-Bang; Lin, Shing-Jong] Natl Yang Ming Univ, Sch Med, Inst Clin Med, Taipei 112, Taiwan.
   [Lin, Shing-Jong; Chen, Jaw-Wen] Taipei Vet Gen Hosp, Dept Med Res & Educ, Taipei, Taiwan.
   [Chen, Jaw-Wen] Natl Yang Ming Univ, Sch Med, Inst Pharmacol, Taipei 112, Taiwan.
C3 Taipei Veterans General Hospital; National Yang Ming Chiao Tung
   University; National Yang Ming Chiao Tung University; Taipei Veterans
   General Hospital; National Yang Ming Chiao Tung University
RP Chen, JW (corresponding author), Taipei Vet Gen Hosp, Div Cardiol, Dept Internal Med, 201 Sec 2,Shih Pai Rd, Taipei, Taiwan.
EM jwchen@vghtpe.gov.tw
RI Huang, Po-Hsun/A-2713-2015; Chen, jianhui/AAY-1195-2021
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NR 32
TC 33
Z9 33
U1 0
U2 4
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 1355-6037
J9 HEART
JI Heart
PD AUG
PY 2010
VL 96
IS 15
BP 1227
EP 1232
DI 10.1136/hrt.2009.192393
PG 6
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 626HJ
UT WOS:000279956700014
PM 20639239
DA 2025-06-11
ER

PT J
AU Gulli, G
   Cemin, R
   Pancera, P
   Menegatti, G
   Vassanelli, C
   Cevese, A
AF Gulli, G
   Cemin, R
   Pancera, P
   Menegatti, G
   Vassanelli, C
   Cevese, A
TI Evidence of parasympathetic impairment in some patients with cardiac
   syndrome X
SO CARDIOVASCULAR RESEARCH
LA English
DT Article
DE autonomic nervous system; coronary disease; heart rate (variability);
   microcirculation
ID NORMAL CORONARY-ARTERIES; SPECTRAL-ANALYSIS; ANGINA-PECTORIS; HEART
   PERIOD; DYSFUNCTION; BAROREFLEX; PAIN; VASODILATION; PERCEPTION;
   RESISTANCE
AB Objectives: Cardiac syndrome X (SX) is a clinical condition characterised by angina, positive exercise stress test and negative coronary angiography it has often been attributed to sympathetic hyperactivity. Here we tested the hypothesis that a parasympathetic, rather than a sympathetic, dysfunction could be the cause of the autonomic imbalance observed in SX. Methods: In 20 subjects with diagnosed SX and in 12 age-matched controls, we studied autonomic function by performing spectral analysis of RR interval and finger arterial pressure (SAP), in supine position and during head-up tilting. We also carried out a set of tests of parasympathetic function. Results: The group of SX patients did not differ significantly from control subjects in any of the variables tested. In a subgroup of 13 SX, however, tilting increased the low-frequency power of SAP, but did not induce the expected increase in low-frequency and decrease in high-frequency power of RR. These patients, in supine position, had significantly lower sinus arrhythmia and a higher ratio of low to high frequency of RR, in comparison with control subjects. We interpreted these differences as signs of reduced parasympathetic, but essentially normal sympathetic, activity. The parasympathetic tests confirmed vagal impairment in the same SX subjects. On the other hand, all the tests indicated normal parasympathetic functions in the control subjects and in those SX patients who displayed the expected spectral changes in tilting. Conclusions: In about two thirds of the patients with SX, the pathophysiological mechanism causing the symptoms could be related to the reduced parasympathetic tone, rather than to an augmented sympathetic activity. (C) 2001 Elsevier Science B.V. All rights reserved.
C1 Univ Verona, Dept Neurol Sci & Vis, I-37134 Verona, Italy.
   Univ Verona, Dept Biomed & Surg Sci, Cardiol Sect, I-37134 Verona, Italy.
   Civic Hosp San Bonifacio, Unit Internal Med, Verona, Italy.
   Univ Piemonte Orientale, Div Cardiol, Novara, Italy.
C3 University of Verona; University of Verona; University of Eastern
   Piedmont Amedeo Avogadro
RP Univ Verona, Dept Neurol Sci & Vis, Strada Le Grazie 8, I-37134 Verona, Italy.
EM antonio.cevese@univr.it
RI Cemin, Roberto/ITR-9833-2023; Gulli, Giosue/KGL-3320-2024
OI Gulli, Giosue/0000-0002-4540-7053
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NR 41
TC 35
Z9 39
U1 0
U2 3
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0008-6363
EI 1755-3245
J9 CARDIOVASC RES
JI Cardiovasc. Res.
PD NOV
PY 2001
VL 52
IS 2
BP 208
EP 216
AR PII S0008-6363(01)00369-8
DI 10.1016/S0008-6363(01)00369-8
PG 9
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 542HQ
UT WOS:000175037800007
PM 11684068
DA 2025-06-11
ER

PT J
AU Lu, DY
   Yang, AC
   Cheng, HM
   Lu, TM
   Yu, WC
   Chen, CH
   Sung, SH
AF Lu, Dai-Yin
   Yang, Albert C.
   Cheng, Hao-Min
   Lu, Tse-Min
   Yu, Wen-Chung
   Chen, Chen-Huan
   Sung, Shih-Hsien
TI Heart Rate Variability Is Associated with Exercise Capacity in Patients
   with Cardiac Syndrome X
SO PLOS ONE
LA English
DT Article
ID LEFT-VENTRICULAR FUNCTION; POWER SPECTRUM ANALYSIS; ANGINA-PECTORIS;
   RATE RECOVERY; MECHANISMS; DYSFUNCTION; PREDICTORS; MORTALITY; ENDURANCE
AB Heart rate variability (HRV) reflects the healthiness of autonomic nervous system, which is associated with exercise capacity. We therefore investigated whether HRV could predict the exercise capacity in the adults with cardiac syndrome X (CSX). A total of 238 subjects (57 +/- 12 years, 67.8% men), who were diagnosed as CSX by the positive exercise stress test and nearly normal coronary angiogram were enrolled. Power spectrum from the 24-hour recording of heart rate was analyzed in frequency domain using total power (TP) and spectral components of the very low frequency (VLF), low frequency (LF) and high frequency (HF) ranges. Among the study population, 129 subjects with impaired exercise capacity during the treadmill test had significantly lower HRV indices than those with preserved exercise capacity (>= 90% of the age predicted maximal heart rate). After accounting for age, sex, and baseline SBP and heart rate, VLF (odds ratio per 1SD and 95% CI: 2.02, 1.19-3.42), LF (1.67, 1.10-2.55), and TP (1.82, 1.17-2.83) remained significantly associated with preserved exercise capacity. In addition, increased HRV indices were also associated with increased exercise duration, rate-pressure product, and heart rate recovery, independent of age, body mass index, and baseline SBP and heart rate. In subgroup analysis, HRV indices demonstrated similar predictive values related to exercise capacity across various subpopulations, especially in the young. In patients with CSX, HRV was independently associated with exercise capacity, especially in young subjects. The healthiness of autonomic nervous system may have a role in modulating the exercise capacity in patients with CSX.
C1 [Lu, Dai-Yin; Lu, Tse-Min; Yu, Wen-Chung; Sung, Shih-Hsien] Taipei Vet Gen Hosp, Dept Med, Taipei, Taiwan.
   [Yang, Albert C.] Taipei Vet Gen Hosp, Dept Psychiat, Taipei, Taiwan.
   [Cheng, Hao-Min; Chen, Chen-Huan] Taipei Vet Gen Hosp, Dept Med Educ, Taipei, Taiwan.
   [Lu, Dai-Yin; Yu, Wen-Chung] Natl Yang Ming Univ, Inst Clin Med, Taipei 112, Taiwan.
   [Lu, Dai-Yin; Yang, Albert C.; Cheng, Hao-Min; Lu, Tse-Min; Chen, Chen-Huan; Sung, Shih-Hsien] Natl Yang Ming Univ, Dept Med, Taipei 112, Taiwan.
   [Chen, Chen-Huan; Sung, Shih-Hsien] Natl Yang Ming Univ, Dept Publ Hlth, Taipei 112, Taiwan.
   [Yang, Albert C.] Natl Cent Univ, Res Ctr Adapt Data Anal, Taoyuan, Taiwan.
C3 Taipei Veterans General Hospital; Taipei Veterans General Hospital;
   Taipei Veterans General Hospital; National Yang Ming Chiao Tung
   University; National Yang Ming Chiao Tung University; National Yang Ming
   Chiao Tung University; National Central University
RP Sung, SH (corresponding author), Taipei Vet Gen Hosp, Dept Med, Taipei, Taiwan.; Sung, SH (corresponding author), Natl Yang Ming Univ, Dept Med, Taipei 112, Taiwan.; Sung, SH (corresponding author), Natl Yang Ming Univ, Dept Publ Hlth, Taipei 112, Taiwan.
EM mr.sungsh@gmail.com
RI Cheng, Hao-min/L-2576-2018; Yang, Albert/JSL-0102-2023; Chen,
   Wei-Yi/CAI-6775-2022
OI Yang, Albert Chih-Chieh/0000-0003-2794-9649
FU Taipei Veterans General Hospital [V103B-017]; Ministry of Health and
   Welfare, Taiwan [MOHW-104-TDU-B-211-113003]
FX The study was supported by Taipei Veterans General Hospital (V103B-017),
   and Ministry of Health and Welfare, Taiwan (MOHW-104-TDU-B-211-113003).
   The funders had no role in study design, data collection and analysis,
   decision to publish, or preparation of the manuscript.
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NR 35
TC 9
Z9 11
U1 0
U2 6
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JAN 26
PY 2016
VL 11
IS 1
AR e0144935
DI 10.1371/journal.pone.0144935
PG 11
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA DC9GB
UT WOS:000369528000001
PM 26812652
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Fragasso, G
   Chierchia, SL
   Dosio, F
   Rossetti, E
   Gianolli, L
   Picchio, M
   Margonato, A
   Fazio, F
AF Fragasso, G
   Chierchia, SL
   Dosio, F
   Rossetti, E
   Gianolli, L
   Picchio, M
   Margonato, A
   Fazio, F
TI High prevalence of <SUP>99m</SUP>tc-tetrofosmin reverse perfusion
   pattern in patients with myocardial infarction and angiographically
   smooth coronary arteries
SO INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING
LA English
DT Article
DE myocardial infarction; myocardial perfusion scintigraphy; normal
   coronary arteries; reverse redistribution
ID SYNDROME-X; REDISTRIBUTION PHENOMENON; YOUNG-WOMEN; TL-201; ANGINA;
   ISCHEMIA; DISEASE; CINEARTERIOGRAPHY; SCINTIGRAPHY; PATENCY
AB Background: There are no published data in the literature on the scintigraphic perfusion pattern in patients with myocardial infarction (MI) and normal coronary arteries (NCA). Objectives: To evaluate myocardial perfusion imaging in a series of patients with MI and NCA. Methods: Twenty-seven patients who had developed a MI and had NCA were studied. As a control group we included 27 patients with a recent MI and coronary artery disease (CAD). All patients underwent stress/rest tetrofosmin myocardial perfusion SPECT within 6 months from MI. Results: In patients with NCA tetrofosmin stress images revealed 41 hypoperfused segments in 17 patients (63%). On rest images, 13 segments remained unchanged, 4 showed partial reperfusion, 10 normalized and 14 worsened. Additionally, there were 18 new hypoperfused segments in nine patients. Therefore, perfusion worsened at rest in 18 patients (67%) (32 segments). Overall, at rest there were 49 hypoperfused segments in 22 patients (81%). In patients with CAD, stress images revealed 71 hypoperfused segments. On rest images, 39 segments remained unchanged, 16 showed partial reperfusion and 12 normalized. Four segments worsened at rest and only four patients (15%) showed new perfusion defects at rest. Conclusions: Myocardial perfusion with tetrofosmin might appear considerably worse at rest than at stress in patients with MI and NCA. Specifically, a reverse perfusion pattern in the infarct area is a frequent finding and is likely to be due to residual tissue viability. We postulate that in these patients the hyperemic response to exercise may mask resting underperfusion areas.
C1 Univ Milano Bicocca, Hosp San Raffaele, Ist Sci,Clin Cardiol Unit, Dept Cardiol & Cardiovasc Sci,Div Cardiol, I-20132 Milan, Italy.
   Univ Milano Bicocca, Hosp San Raffaele, Ist Sci, CNR,INB, I-20132 Milan, Italy.
C3 Vita-Salute San Raffaele University; IRCCS Ospedale San Raffaele;
   University of Milano-Bicocca; Consiglio Nazionale delle Ricerche (CNR);
   Vita-Salute San Raffaele University; IRCCS Ospedale San Raffaele;
   University of Milano-Bicocca
RP Fragasso, G (corresponding author), Univ Milano Bicocca, Hosp San Raffaele, Ist Sci,Clin Cardiol Unit, Dept Cardiol & Cardiovasc Sci,Div Cardiol, Via Olgettina 60, I-20132 Milan, Italy.
RI gianolli, luigi/AAN-3892-2020; MARGONATO, ALBERTO/B-4185-2015; fragasso,
   gabriele/K-5483-2012; Picchio, Maria/K-4941-2016
OI Picchio, Maria/0000-0002-7532-6211
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NR 49
TC 4
Z9 4
U1 0
U2 2
PU KLUWER ACADEMIC PUBL
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0167-9899
J9 INT J CARDIOVAS IMAG
JI Int. J. Cardiovasc. Imaging
PD FEB
PY 2002
VL 18
IS 1
BP 31
EP 40
DI 10.1023/A:1014373209524
PG 10
WC Cardiac & Cardiovascular Systems; Radiology, Nuclear Medicine & Medical
   Imaging
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Radiology, Nuclear Medicine &
   Medical Imaging
GA 568MJ
UT WOS:000176545700005
PM 12135120
DA 2025-06-11
ER

PT J
AU Rodriguez, O
   Picano, E
   Fedele, S
   Morelos, M
   Marzilli, M
AF Rodriguez, O
   Picano, E
   Fedele, S
   Morelos, M
   Marzilli, M
TI Noninvasive prediction of coronary artery disease progression by
   comparison of serial exercise electrocardiography and dipyridamole
   stress echocardiography
SO INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING
LA English
DT Article
DE atherosclerosis; dipyridamole; echocardiography; stress
ID CARDIAC ALLOGRAFT VASCULOPATHY; POSITRON EMISSION TOMOGRAPHY; LOW-FAT
   DIET; CHEST PAIN; MYOCARDIAL PERFUSION; SYNDROME-X; PROGNOSTIC VALUE;
   CLINICAL-TRIALS; ANGINA-PECTORIS; ANGIOGRAPHY
AB Background: The possibility of noninvasive prediction of angiographically assessed coronary artery disease (CAD) progression by comparison of serial studies of exercise electrocardiography (EET) and dipyridamole stress echocardiography (DET) is not known. Aim: To assess the relative value of EET and DET in predicting angiographically assessed progression of CAD. Methods: From the Institute of Clinical Physiology, National Research Council, Pisa Italy stress echo data bank (1983-1998), we selected 46 patients with two repeated EET, DET and coronary angiography (CA) in two different hospital admissions (46 30 months). A priori, angiographic progressors were defined as any stenosis progression to occlusion and/or any stenosis >30% with >20% stenosis progression measured by visual and quantitative CA. EET progressors were defined as a previous negative test becoming positive or as a positive test with decrease in ischemic threshold response in the second test. DET progressors were defined as previous negative test becoming positive or as a positive test with a more severe ischemic response in the second test. Results: Angiographic progressors were 31/46 patients (67%) and angiographic nonprogressors were 15/46 (33%). When angiography was taken as the gold standard, there were no differences in sensitivity for EET and DET (87 vs. 87%). Specificity was significantly higher for DET (93 vs. 40% p =< 0.001). By κ statistics DET had a good concordance (κ = 0.768) and EET a poor concordance (κ = 0.299) with angiographic progression. Conclusion: DET is more accurate than EET at predicting angiographically assessed CAD progression.
C1 CNR, Inst Clin Physiol, I-56100 Pisa, Italy.
   Inst Mexicano Seguridad Social, Mexico City, DF, Mexico.
C3 Consiglio Nazionale delle Ricerche (CNR); Istituto di Fisiologia Clinica
   (IFC-CNR); Instituto Mexicano del Seguro Social
RP Picano, E (corresponding author), CNR, Inst Clin Physiol, Via Moruzzi 1, I-56100 Pisa, Italy.
RI Picano, E/G-2261-2014
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NR 35
TC 2
Z9 2
U1 0
U2 0
PU KLUWER ACADEMIC PUBL
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0167-9899
J9 INT J CARDIOVAS IMAG
JI Int. J. Cardiovasc. Imaging
PD APR
PY 2002
VL 18
IS 2
BP 93
EP 99
DI 10.1023/A:1014672704210
PG 7
WC Cardiac & Cardiovascular Systems; Radiology, Nuclear Medicine & Medical
   Imaging
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Radiology, Nuclear Medicine &
   Medical Imaging
GA 568ML
UT WOS:000176545900003
PM 12108913
DA 2025-06-11
ER

PT J
AU Pilz, G
   Klos, M
   Ali, E
   Hoefling, B
   Scheck, R
   Bernhardt, P
AF Pilz, Guenter
   Klos, Markus
   Ali, Eman
   Hoefling, Berthold
   Scheck, Roland
   Bernhardt, Peter
TI Angiographic correlations of patients with small vessel disease
   diagnosed by adenosine-stress cardiac magnetic resonance imaging
SO JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE
LA English
DT Article
ID CORONARY-ARTERY-DISEASE; TIMI FRAME COUNT; FRACTIONAL FLOW RESERVE;
   MYOCARDIAL-PERFUSION; SYNDROME-X; ANGINA-PECTORIS; CHEST-PAIN;
   MICROVASCULAR ANGINA; FOLLOW-UP; INFARCTION
AB Cardiac magnetic resonance imaging (CMR) with adenosine-stress myocardial perfusion is gaining importance for the detection and quantification of coronary artery disease (CAD). However, there is little knowledge about patients with CMR-detected ischemia, but having no relevant stenosis as seen on coronary angiography (CA). The aims of our study were to characterize these patients by CMR and CA and evaluate correlations and potential reasons for the ischemic findings. 73 patients with an indication for CA were first scanned on a 1.5T whole-body CMR-scanner including adenosine-stress first-pass perfusion. The images were analyzed by two independent investigators for myocardial perfusion which was classified as subendocardial ischemia (n = 22), no perfusion deficit (n = 27, control 1), or more than subendocardial ischemia (n = 24, control 2). All patients underwent CA, and a highly significant correlation between the classification of CMR perfusion deficit and the degree of coronary luminal narrowing was found. For quantification of coronary blood flow, corrected Thrombolysis in Myocardial Infarction (TIMI) frame count (TFC) was evaluated for the left anterior descending (LAD), circumflex (LCX) and right coronary artery (RCA). The main result was that corrected TFC in all coronaries was significantly increased in study patients compared to both control 1 and to control 2 patients. Study patients had hypertension or diabetes more often than control 1 patients. In conclusion, patients with CMR detected subendocardial ischemia have prolonged coronary blood flow. In connection with normal resting flow values in CAD, this supports the hypothesis of underlying coronary microvascular impairment. CMR stress perfusion differentiates non-invasively between this entity and relevant CAD.
C1 [Pilz, Guenter; Klos, Markus; Ali, Eman; Hoefling, Berthold; Bernhardt, Peter] Hosp Univ Munich, Dept Cardiol, Clin Agatharied, Acad Teaching, Munich, Germany.
   [Scheck, Roland] Hosp Univ Munich, Dept Radiol, Clin Agatharied, Acad Teaching, Munich, Germany.
   [Bernhardt, Peter] Univ Ulm, Dept Med 2, D-89069 Ulm, Germany.
C3 University of Munich; University of Munich; Ulm University
RP Pilz, G (corresponding author), Hosp Univ Munich, Dept Cardiol, Clin Agatharied, Acad Teaching, Munich, Germany.
EM pilz@khagatharied.de; klos@khagatharied.de; ali@khagatharied.de;
   hoefling@khagatharied.de; scheck@khagatharied.de; Peter.Bernhardt@web.de
RI Ali, Eman/R-2789-2019
OI Ali, Eman/0000-0002-9325-4194
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NR 40
TC 49
Z9 49
U1 0
U2 1
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1097-6647
J9 J CARDIOVASC MAGN R
JI J. Cardiov. Magn. Reson.
PD JAN 31
PY 2008
VL 10
AR 8
DI 10.1186/1532-429X-10-8
PG 9
WC Cardiac & Cardiovascular Systems; Radiology, Nuclear Medicine & Medical
   Imaging
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Radiology, Nuclear Medicine &
   Medical Imaging
GA 319JS
UT WOS:000257160500001
PM 18275591
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU de Beijer, IAE
   Bouwman, E
   Mulder, RL
   Steensma, P
   Brown, MC
   Araujo-Soares, V
   Balcerek, M
   Bardi, E
   Winther, JF
   Frederiksen, LE
   van Gorp, M
   Oberti, S
   van Kalsbeek, RJ
   Kepak, T
   Kepakova, K
   Gsell, H
   Kienesberger, A
   van Litsenburg, R
   Mader, L
   Michel, G
   Muraca, M
   van den Oever, SR
   van der Pal, HJH
   Roser, K
   Skinner, R
   Stolman, I
   Uyttebroeck, A
   Kremer, LCM
   Loonen, J
   van Dalen, EC
   Pluijm, SMF
AF de Beijer, Ismay A. E.
   Bouwman, Eline
   Mulder, Renee L.
   Steensma, Philippa
   Brown, Morven C.
   Araujo-Soares, Vera
   Balcerek, Magdalena
   Bardi, Edit
   Falck Winther, Jeanette
   Frederiksen, Line Elmerdahl
   van Gorp, Marloes
   Oberti, Sara
   van Kalsbeek, Rebecca J.
   Kepak, Tomas
   Kepakova, Katerina
   Gsell, Hannah
   Kienesberger, Anita
   van Litsenburg, Raphaele
   Mader, Luzius
   Michel, Gisela
   Muraca, Monica
   van den Oever, Selina R.
   van Der Pal, Helena J. H.
   Roser, Katharina
   Skinner, Roderick
   Stolman, Iridi
   Uyttebroeck, Anne
   Kremer, Leontien C. M.
   Loonen, Jacqueline
   van Dalen, Elvira C.
   Pluijm, Saskia M. F.
CA PanCareFollowUp Consortium
TI Barriers, facilitators, and other factors associated with health
   behaviors in childhood, adolescent, and young adult cancer survivors: A
   systematic review
SO CANCER MEDICINE
LA English
DT Review
DE barriers; CAYA cancer survivors; facilitators; factors; health
   behaviors; healthy lifestyle; pediatric oncology; systematic review
ID PHYSICAL PERFORMANCE LIMITATIONS; RISK-FACTORS; METABOLIC SYNDROME;
   LIFE-STYLE; SMOKING; PARTNERSHIP; EXERCISE; INTERVENTION; CHEMOTHERAPY;
   CESSATION
AB BackgroundHealthy behaviors are paramount in preventing long-term adverse health outcomes in childhood, adolescent, and young adult (CAYA) cancer survivors. We systematically reviewed and synthesized existing literature on barriers, facilitators, and other factors associated with health behaviors in this population.MethodsMEDLINE and PsycInfo were searched for qualitative and quantitative studies including survivors aged 16-50 years at study, a cancer diagnosis <= 25 years and >= 2 years post diagnosis. Health behaviors included physical activity, smoking, diet, alcohol consumption, sun exposure, and a combination of these behaviors (defined as health behaviors in general).ResultsBarriers, facilitators, and other factors reported in >= 2 two studies were considered relevant. Out of 4529 studies, 27 were included (n = 31,905 participants). Physical activity was the most frequently examined behavior (n = 12 studies), followed by smoking (n = 7), diet (n = 7), alcohol (n = 4), sun exposure (n = 4), and health behavior in general (n = 4). Relevant barriers to physical activity were fatigue, lack of motivation, time constraints, and current smoking. Relevant facilitators were perceived health benefits and motivation. Influence of the social environment and poor mental health were associated with more smoking, while increased energy was associated with less smoking. No relevant barriers and facilitators were identified for diet, alcohol consumption, and sun exposure. Barriers to healthy behavior in general were unmet information needs and time constraints whereas lifestyle advice, information, and discussions with a healthcare professional facilitated healthy behavior in general. Concerning other factors, women were more likely to be physically inactive, but less likely to drink alcohol and more likely to comply with sun protection recommendations than men. Higher education was associated with more physical activity, and lower education with more smoking.ConclusionThis knowledge can be used as a starting point to develop health behavior interventions, inform lifestyle coaches, and increase awareness among healthcare providers regarding which survivors are most at risk of unhealthy behaviors.
C1 [de Beijer, Ismay A. E.; Mulder, Renee L.; Steensma, Philippa; van Gorp, Marloes; van Kalsbeek, Rebecca J.; van Litsenburg, Raphaele; van den Oever, Selina R.; van Der Pal, Helena J. H.; Kremer, Leontien C. M.; van Dalen, Elvira C.; Pluijm, Saskia M. F.] Princess Maxima Ctr Pediat Oncol, Heidelberglaan 25, Utrecht, Netherlands.
   [Bouwman, Eline; Stolman, Iridi; Loonen, Jacqueline] Radboud Univ Nijmegen, Radboud Inst Hlth Sci, Med Ctr, Dept Hematol, Nijmegen, Netherlands.
   [Brown, Morven C.] Newcastle Univ, Populat Hlth Sci Inst, Ctr Canc, Newcastle Upon Tyne, England.
   [Araujo-Soares, Vera] Heidelberg Univ, Med Fac Mannheim, Ctr Prevent Med & Digital Hlth, Dept Prevent, Mannheim, Germany.
   [Balcerek, Magdalena] Dept Pediat Oncol & Hematol, Charite Univ Med Berlin, Berlin, Germany.
   [Balcerek, Magdalena] Free Univ Berlin, Berlin, Germany.
   [Balcerek, Magdalena] Humboldt Univ, Berlin, Germany.
   [Bardi, Edit] St Anna Childrens Hosp, Vienna, Austria.
   [Bardi, Edit] Kepler Univ Clin, Dept Pediat & Adolescent Med, Linz, Austria.
   [Falck Winther, Jeanette; Frederiksen, Line Elmerdahl; Mader, Luzius] Danish Canc Soc Res Ctr, Childhood Canc Res Grp, Copenhagen, Denmark.
   [Falck Winther, Jeanette] Aarhus Univ, Dept Clin Med, Aarhus, Denmark.
   [Falck Winther, Jeanette] Aarhus Univ, Fac Hlth, Aarhus, Denmark.
   [Oberti, Sara; Muraca, Monica] IRCCS Ist Giannina Gaslini, Dept Hematol Oncol, DOPO Clin, Genoa, Italy.
   [Kepak, Tomas; Kepakova, Katerina] St Annes Univ Hosp Brno, Int Clin Res Ctr, Brno, Czech Republic.
   [Gsell, Hannah; Kienesberger, Anita] Childhood Canc Int Europe, Vienna, Austria.
   [Mader, Luzius] Univ Bern, Inst Social & Prevent Med, Bern, Switzerland.
   [Michel, Gisela; Roser, Katharina] Univ Lucerne, Fac Hlth Sci & Med, Luzern, Switzerland.
   [van Der Pal, Helena J. H.] PanCare, Bussum, Netherlands.
   [Skinner, Roderick] Great North Childrens Hosp, Royal Victoria Infirm, Newcastle Upon Tyne, England.
   [Skinner, Roderick] Wolfson Childhood Canc Res Ctr, Translat & Clin Res Inst, Newcastle Upon Tyne, England.
   [Uyttebroeck, Anne] Katholieke Univ Leuven, Univ Hosp Leuven, Dept Oncol, Dept Paediat Haematol & Oncol,Paediat Oncol, Leuven, Belgium.
   [Kremer, Leontien C. M.] Emma Childrens Hosp, Dept Paediat, Amsterdam, Netherlands.
   [Kremer, Leontien C. M.] Univ Utrecht, Fac Med, Utrecht, Netherlands.
C3 Princess Maxima Center; Radboud University Nijmegen; Newcastle
   University - UK; Ruprecht Karls University Heidelberg; Berlin Institute
   of Health; Free University of Berlin; Humboldt University of Berlin;
   Charite Universitatsmedizin Berlin; Free University of Berlin; Humboldt
   University of Berlin; Saint Anna Children's Hospital; Kepler University
   Hospital; Danish Cancer Society; Aarhus University; Aarhus University;
   University of Genoa; IRCCS Istituto Giannina Gaslini; St. Anne's
   University Hospital Brno (FNUSA); St. Anne's University Hospital Brno
   (FNUSA-ICRC); University of Bern; Swiss School of Public Health (SSPH+);
   University of Lucerne; Newcastle University - UK; KU Leuven; University
   Hospital Leuven; Emma Children's Hospital; University of Amsterdam;
   Utrecht University
RP de Beijer, IAE (corresponding author), Princess Maxima Ctr Pediat Oncol, Heidelberglaan 25, Utrecht, Netherlands.
EM i.a.e.debeijer-3@prinsesmaximacentrum.nl
RI Michel, Gisela/G-1081-2018; Loonen, J.J./L-4495-2015; Roser,
   Katharina/AAI-1429-2020; Kepak, Tomas/AAT-6482-2020; Muraca,
   Monica/ABF-4444-2020; Bouwman, Eline/A-6653-2018; Winther,
   Jeanette/AAS-2754-2020; Araujo-Soares, Vera/ABF-8144-2021; van Gorp,
   Marloes/ABE-9739-2020
OI Strublova, Lucie/0009-0001-1194-4475; Bouwman,
   Eline/0000-0002-9149-9745; Kepakova, Katerina/0000-0002-7508-7193;
   Winther, Jeanette Falck/0000-0002-3440-5108; Kepak,
   Tomas/0000-0002-1449-5273
FU European Union [824982]; H2020 Societal Challenges Programme [824982]
   Funding Source: H2020 Societal Challenges Programme
FX This work was supported by the European Union's Horizon 2020 Framework
   Program (Grant Number 824982). The funder had no role in study design,
   data collection, data analysis, data interpretation, or in writing the
   report. The material presented and views expressed here are the
   responsibility of the author(s) only. The EU Commission takes no
   responsibility for any use made of the information set out
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NR 69
TC 2
Z9 2
U1 5
U2 8
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2045-7634
J9 CANCER MED-US
JI Cancer Med.
PD JUN
PY 2024
VL 13
IS 12
AR e7361
DI 10.1002/cam4.7361
PG 30
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA UX7O4
UT WOS:001251431100001
PM 39291862
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Daré, LO
   Bruand, PE
   Gérard, D
   Marin, B
   Lameyre, V
   Boumédiène, F
   Preux, PM
AF Dare, Labante Outcha
   Bruand, Pierre-Emile
   Gerard, Daniel
   Marin, Benoit
   Lameyre, Valerie
   Boumediene, Farid
   Preux, Pierre-Marie
TI Co-morbidities of mental disorders and chronic physical diseases in
   developing and emerging countries: a meta-analysis
SO BMC PUBLIC HEALTH
LA English
DT Article
DE Meta-analysis; Association; Comorbidities; Mental disorders; Chronic
   diseases
ID OBSTRUCTIVE PULMONARY-DISEASE; QUALITY-OF-LIFE; TYPE-2
   DIABETES-MELLITUS; CANCER-PATIENTS; RISK-FACTORS; PSYCHIATRIC MORBIDITY;
   HEART-DISEASE; GLOBAL BURDEN; DEPRESSIVE SYMPTOMS; METABOLIC SYNDROME
AB BackgroundAs the data on the association of mental disorders and chronic physical diseases in developing and emerging countries is heterogeneous, this study aims to produce the first meta-analysis of these comorbidities.MethodologyThe meta-analysis protocol was registered in PROSPERO (N degrees CRD42017056521) and was performed in accordance with PRISMA guidelines. Initially, an article search was conducted on Medline, Embase, Lilacs and the Institut d'Epidemiologie et de Neurologie Tropicale database [Institute of Epidemiology and Tropical Neurology], as well as manually, with no restriction on language or date focusing on mental disorders, chronic diseases and neurotropic diseases. Two independent investigators assessed the quality of the studies which met the inclusion criteria using the Downs and Black assessment grid. The pooled estimates were calculated out using a random-effects method with CMA software Version 3.0. A meta-regression was then performed, and the significance level was set at 0.05.ResultsOf the 2604 articles identified, 40 articles involving 21,747 subjects met the inclusion criteria for co-morbidities between mental disorders and chronic physical diseases. Thirty-one articles were included in the meta-analysis of prevalence studies and 9 articles in that of the analytical studies. The pooled prevalence of mental disorders in patients with chronic physical diseases was 36.6% (95% CI, 31.4-42.1) and the pooled odds ratio was 3.1 (95% CI, 1.7-5.2). There was heterogeneity in all the estimates and in some cases, this was explained by the quality of the studies.ConclusionSome estimates regarding the prevalence of mental disorders in people with chronic physical diseases living in developing and emerging countries were similar to those in developed countries. Mental disorders are a burden in these countries. In order to respond effectively and efficiently to the morbidity and mortality associated with them, mental health care could be integrated with physical care.
C1 [Dare, Labante Outcha; Marin, Benoit; Boumediene, Farid; Preux, Pierre-Marie] Univ Limoges, Inst Neuroepidemiol & Trop Neurol, Trop Neuroepidemiol, INSERM,CHU Limoges,UMR S 1094,CNRS FR 3503 GEIST, F-87000 Limoges, France.
   [Bruand, Pierre-Emile; Gerard, Daniel; Lameyre, Valerie] SAG CSVB, Access Med, SANOFI, 82 Ave Raspail, F-94250 Gentilly, France.
C3 CHU Limoges; Universite de Limoges; Centre National de la Recherche
   Scientifique (CNRS); CNRS - National Institute for Biology (INSB);
   Institut National de la Sante et de la Recherche Medicale (Inserm);
   Sanofi-Aventis; Sanofi France
RP Daré, LO (corresponding author), Univ Limoges, Inst Neuroepidemiol & Trop Neurol, Trop Neuroepidemiol, INSERM,CHU Limoges,UMR S 1094,CNRS FR 3503 GEIST, F-87000 Limoges, France.
EM outcha_dare1986@yahoo.com
RI Boumediene, Faiza/Q-7777-2019; Preux, Pierre-Marie/B-8393-2014; MARIN,
   Benoit/E-2356-2015
OI /0000-0003-0075-9271; Bruand, Pierre-Emile/0000-0002-4056-8798; Preux,
   Pierre-Marie/0000-0002-2171-2977; MARIN, Benoit/0000-0001-8857-0910;
   BOUMEDIENE, Farid/0000-0001-9505-683X
FU Sanofi
FX LOD was an intern at Sanofi for six months during which he received a
   grant. Sanofi also provided access to the electronic databases and
   assistance with the finalization of the article.
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NR 103
TC 121
Z9 130
U1 2
U2 7
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2458
J9 BMC PUBLIC HEALTH
JI BMC Public Health
PD MAR 13
PY 2019
VL 19
AR 304
DI 10.1186/s12889-019-6623-6
PG 12
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA HO9QN
UT WOS:000461300200005
PM 30866883
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Lundqvist, S
   Börjesson, M
   Larsson, MEH
   Hagberg, L
   Cider, Å
AF Lundqvist, Stefan
   Borjesson, Mats
   Larsson, Maria E. H.
   Hagberg, Lars
   Cider, Asa
TI Physical Activity on Prescription (PAP), in patients with metabolic risk
   factors. A 6-month follow-up study in primary health care
SO PLOS ONE
LA English
DT Article
ID QUALITY-OF-LIFE; RANDOMIZED CONTROLLED-TRIAL; EXERCISE REFERRAL PROGRAM;
   ACTIVITY QUESTIONNAIRE; SPORTS-MEDICINE; ACTIVITY LEVEL; VALIDITY;
   RELIABILITY; FITNESS; DISEASE
AB There is strong evidence that inadequate physical activity (PA) leads to an increased risk of lifestyle-related diseases and premature mortality. Physical activity on prescription (PAP) is a method to increase the level of PA of patients in primary care, but needs further evaluation. The aim of this observational study was to explore the association between PAP-treatment and the PA level of patients with metabolic risk factors and the relationship between changes in the PA level and health outcomes at the 6 month follow-up. This study included 444 patients in primary care, aged 27-85 years (56% females), who were physically inactive with at least one component of metabolic syndrome. The PAP-treatment model included: individualized dialogue concerning PA, prescribed PA, and a structured follow-up. A total of 368 patients (83%) completed the 6 months of follow-up. Of these patients, 73% increased their PA level and 42% moved from an inadequate PA level to sufficient, according to public health recommendations. There were significant improvements (p <= 0.05) in the following metabolic risk factors: body mass index, waist circumference, systolic blood pressure, fasting plasma glucose, cholesterol, and low density lipoprotein. There were also significant improvements regarding health-related quality of life, assessed by the Short Form 36, in: general health, vitality, social function, mental health, role limitation-physical/emotional, mental component summary, and physical component summary. Regression analysis showed a significant association between changes in the PA level and health outcomes. During the first 6-month period, the caregiver provided PAP support 1-2 times. This study indicates that an individual-based model of PAP-treatment has the potential to change people's PA behavior with improved metabolic risk factors and self-reported quality of life at the 6 month follow-up. Thus, PAP seems to be feasible in a clinical primary care practice, with minimum effort from healthcare professionals.
C1 [Lundqvist, Stefan; Cider, Asa] Univ Gothenburg, Sahlgrenska Acad, Inst Neurosci & Physiol, Dept Hlth & Rehabil,Unit Physotherapy, Gothenburg, Sweden.
   [Lundqvist, Stefan] Narhalsan Rehabil FaR teamet Cent & western Gothe, Gothenburg, Sweden.
   [Borjesson, Mats] Univ Gothenburg, Fac Educ, Dept Food & Nutr & Sport Sci, Gothenburg, Sweden.
   [Borjesson, Mats] Sahlgrens Univ Hosp, Sahlgrenska Acad, Inst Neurosci & Physiol, Gothenburg, Sweden.
   [Larsson, Maria E. H.] Narhalsan Res & Dev Primary Hlth Care, Gothenburg, Sweden.
   [Hagberg, Lars] Univ Orebro, Univ Hlth Care Res Ctr, Fac Med & Hlth, Orebro, Sweden.
C3 University of Gothenburg; University of Gothenburg; University of
   Gothenburg; Sahlgrenska University Hospital; Orebro University
RP Lundqvist, S (corresponding author), Univ Gothenburg, Sahlgrenska Acad, Inst Neurosci & Physiol, Dept Hlth & Rehabil,Unit Physotherapy, Gothenburg, Sweden.; Lundqvist, S (corresponding author), Narhalsan Rehabil FaR teamet Cent & western Gothe, Gothenburg, Sweden.
RI Lundqvist, Stefan/LWI-5029-2024; Larsson, Maria/IZE-0424-2023
FU Narhalsan Research & Development Primary Health Care, Region Vastra
   Gotaland
FX Funding was provided as economic support for doctoral thesis by
   Narhalsan Research & Development Primary Health Care, Region Vastra
   Gotaland, http://www.nartialsan. The funder had no role in study design,
   data collection and analysis, decision to publish, or preparation of the
   manuscript.
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NR 73
TC 26
Z9 29
U1 0
U2 16
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD APR 12
PY 2017
VL 12
IS 4
AR e0175190
DI 10.1371/journal.pone.0175190
PG 20
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Science & Technology - Other Topics
GA ET0LZ
UT WOS:000399955200040
PM 28403151
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Serra-Majem, L
   Román-Viñas, B
   Sanchez-Villegas, A
   Guasch-Ferré, M
   Corella, D
   La Vecchia, C
AF Serra-Majem, Lluis
   Roman-Vinas, Blanca
   Sanchez-Villegas, Almudena
   Guasch-Ferre, Marta
   Corella, Dolores
   La Vecchia, Carlo
TI Benefits of the Mediterranean diet: Epidemiological and molecular
   aspects
SO MOLECULAR ASPECTS OF MEDICINE
LA English
DT Review
DE Mediterranean diet; Metabolomics; Genomics; Food policy; Observational
   studies; Randomized controlled trials
ID HIGH-CARDIOVASCULAR-RISK; HEALTHY LIFE-STYLE; INTIMA-MEDIA THICKNESS;
   ALL-CAUSE MORTALITY; BREAST-CANCER RISK; FOOD-FREQUENCY QUESTIONNAIRE;
   METABOLIC SYNDROME PATIENTS; UNVEILS URINARY CHANGES;
   CORONARY-HEART-DISEASE; DIABETES FOLLOW-UP
AB More than 50 years after the Seven Countries Study, a large number of epidemiological studies have explored the relationship between the Mediterranean diet (MD) and health, through observational, case-control, some longitudinal and a few experimental studies. The overall results show strong evidence suggesting a protective effect of the MD mainly on the risk of cardiovascular disease (CVD) and certain types of cancer. The beneficial effects have been attributed to the types of food consumed, total dietary pattern, components in the food, cooking techniques, eating behaviors and lifestyle behaviors, among others. The aim of this article is to review and summarize the knowledge derived from the literature focusing on the benefits of the MD on health, including those that have been extensively investigated (CVD, cancer) along with more recent issues such as mental health, immunity, quality of life, etc. The review begins with a brief description of the MD and its components. Then we present a review of studies evaluating metabolic biomarkers and genotypes in relation to the MD. Other sections are dedicated to observation and intervention studies for various pathologies. Finally, some insights into the relationship between the MD and sustainability are explored. In conclusion, the research undertaken on metabolomics approaches has identified potential markers for certain MD components and patterns, but more investigation is needed to obtain valid measures. Further evaluation of gene-MD interactions are also required to better understand the mechanisms by which the MD diet exerts its beneficial effects on health. Observation and intervention studies, particularly PREDIMED, have provided invaluable data on the benefits of the MD for a wide range of chronic diseases. However further research is needed to explore the effects of other lifestyle components associated with Mediterranean populations, its environmental impact, as well as the MD extrapolation to non-Mediterranean contexts.
C1 [Serra-Majem, Lluis; Sanchez-Villegas, Almudena] Univ Las Palmas Gran Canaria, Res Inst Biomed & Hlth Sci IUIBS, Las Palmas Gran Canaria, Spain.
   [Serra-Majem, Lluis] CHUIMI, Prevent Med Serv, Canarian Hlth Serv, Las Palmas Gran Canaria, Spain.
   [Serra-Majem, Lluis; Roman-Vinas, Blanca; Sanchez-Villegas, Almudena; Guasch-Ferre, Marta; Corella, Dolores] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr CIBERobn, Madrid, Spain.
   [Serra-Majem, Lluis; Roman-Vinas, Blanca] Univ Barcelona, Nutr Res Fdn, Sci Pk, Barcelona, Spain.
   [Roman-Vinas, Blanca] Univ Girona, Sch Hlth & Sport Sci EUSES, Salt, Spain.
   [Roman-Vinas, Blanca] Univ Ramon Llull, Dept Phys Act & Sport Sci, Barcelona, Spain.
   [Guasch-Ferre, Marta] Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA.
   [Corella, Dolores] Univ Valencia, Genet & Mol Epidemiol Unit, Dept Prevent Med, Valencia, Spain.
   [La Vecchia, Carlo] Univ Milan, Dept Clin Sci & Community Hlth, I-20133 Milan, Italy.
C3 Universidad de Las Palmas de Gran Canaria; CIBER - Centro de
   Investigacion Biomedica en Red; CIBEROBN; Instituto de Salud Carlos III;
   University of Barcelona; Universitat de Girona; Universitat Ramon Llull;
   Harvard University; Harvard T.H. Chan School of Public Health;
   University of Valencia; University of Milan
RP Serra-Majem, L (corresponding author), Univ Las Palmas Gran Canaria, Res Inst Biomed & Hlth Sci, Las Palmas Gran Canaria 35016, Spain.
EM lluis.serra@ulpgc.es
RI Corella, Dolores/L-9888-2014; Guasch-Ferre, Marta/JJM-4619-2023; La
   Vecchia, Carlo/Z-1710-2019; Sanchez-Villegas, Almudena/T-6733-2019
OI Guasch-Ferre, Marta/0000-0001-8525-1404; Roman-Vinas,
   Blanca/0000-0003-1804-2324; Sanchez Villegas,
   Almudena/0000-0001-7733-9238
FU Spanish Ministry of Health (Instituto de Salud Carlos III); Ministerio
   de Economia y Competitividad-Fondo Europeo de Desarrollo Regional
   (FEDER) [CIBER 06/03, PI16/00366, SAF2016-80532-R]; Fundacio la Marato
   de TV3 [538/U/2016]; Generalitat Valenciana [PROMETEO 2017/017]; Italian
   Association of Research on Cancer (AIRC)
FX This study was partially supported by the Spanish Ministry of Health
   (Instituto de Salud Carlos III), the Ministerio de Economia y
   Competitividad-Fondo Europeo de Desarrollo Regional (FEDER) (grants
   CIBER 06/03, PI16/00366 and SAF2016-80532-R), the Fundacio la Marato de
   TV3 (grant 538/U/2016), the Generalitat Valenciana (grant PROMETEO
   2017/017) and the Italian Association of Research on Cancer (AIRC). None
   of these entities were involved with the study design, collection,
   analysis and interpretation of data; in the writing of the report or the
   decision to submit the article for publication.
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NR 445
TC 163
Z9 170
U1 1
U2 35
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0098-2997
EI 1872-9452
J9 MOL ASPECTS MED
JI Mol. Asp. Med.
PD JUN
PY 2019
VL 67
BP 1
EP 55
DI 10.1016/j.mam.2019.06.001
PG 55
WC Biochemistry & Molecular Biology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Research & Experimental Medicine
GA IH2ST
UT WOS:000474345500001
PM 31254553
DA 2025-06-11
ER

PT J
AU Compton, MT
   Daumit, GL
   Druss, BG
AF Compton, Michael T.
   Daumit, Gail L.
   Druss, Benjamin G.
TI Cigarette smoking and overweight/obesity among individuals with serious
   mental illnesses: A preventive perspective
SO HARVARD REVIEW OF PSYCHIATRY
LA English
DT Review
DE health behaviors; mental disorders; obesity; smoking
ID INDUCED WEIGHT-GAIN; BODY-MASS INDEX; BUPROPION SUSTAINED-RELEASE;
   CORONARY-HEART-DISEASE; PHYSICAL-ACTIVITY; NICOTINE DEPENDENCE;
   METABOLIC SYNDROME; TOBACCO USE; PSYCHIATRIC-DISORDERS; CARDIOVASCULAR
   RISK
AB Background: Cigarette smoking and lifestyle factors underlying overweight/obesity (such as unhealthy diet and physical inactivity) appear to play a major role in the excess medical morbidity and mortality among persons with serious mental illnesses. The literature on the prevalence, etiology, prevention, and treatment of these two risk factors, in the context of serious mental illnesses, are reviewed following a preventive approach. Methods: The review relied upon searches of the MEDLINE database, from 1996 through April 2006, restricted to the English language. Original research, review articles, and clinical guidelines relevant to the topics of cigarette smoking, unhealthy diet, physical inactivity, and overweight/obesity among individuals with serious mental illnesses were identified. Results: Compared to those without a mental illness, individuals with a current mental illness are more than twice as likely to smoke cigarettes and more than 50% more likely to be overweight/obese, presumably the product of unhealthy diet and physical inactivity. Various biological, iatrogenic, and social factors place psychiatric patients at risk for these and other adverse health behaviors. Studies suggest that many of the same preventive approaches developed for general medical populations are likely to be effective in persons with serious mental disorders, though specialized approaches also are needed. Domains of prevention include primary prevention (population-based strategies to reduce the incidence of these adverse health behaviors), secondary prevention (early detection and treatment), and tertiary prevention (pharmacological and psychosocial treatments to reduce the burden of illness among those with the behaviors in question). However, mental health clinicians commonly lack the training or expertise to provide these services. Conclusions: The high prevalence, adverse effects, and efficaciousness of treatments for smoking and obesity in persons with serious mental illnesses suggest the importance of addressing these problems in this population. Both further research and dissemination efforts are needed to ensure that patients with serious mental illnesses receive the appropriate preventive and clinical services for these two adverse health conditions.
C1 Emory Univ, Sch Med, Dept Psychiat & Behav Sci, Atlanta, GA 30303 USA.
   Emory Univ, Sch Med, Dept Family & Prevent Med, Atlanta, GA 30303 USA.
   Emory Univ, Sch Med, Dept Hlth Policy & Management, Atlanta, GA 30303 USA.
   Johns Hopkins Med Inst, Dept Med, Div Gen Internal Med, Baltimore, MD 21205 USA.
C3 Emory University; Emory University; Emory University; Johns Hopkins
   University; Johns Hopkins Medicine
RP Compton, MT (corresponding author), Emory Univ, Sch Med, Dept Psychiat & Behav Sci, 49 Jesse Hill Dr Dr,SE,Room 333, Atlanta, GA 30303 USA.
EM mcompto@emory.edu
RI Compton, Michael/C-2350-2011
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NR 138
TC 122
Z9 140
U1 0
U2 13
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1067-3229
EI 1465-7309
J9 HARVARD REV PSYCHIAT
JI Harv. Rev. Psychiatr.
PD JUL-AUG
PY 2006
VL 14
IS 4
BP 212
EP 222
DI 10.1080/10673220600889256
PG 11
WC Psychiatry
WE Social Science Citation Index (SSCI)
SC Psychiatry
GA 085YS
UT WOS:000240640900005
PM 16912007
DA 2025-06-11
ER

PT J
AU Bleil, ME
   Roisman, G
   Gregorich, SE
   Appelhans, BM
   Hiatt, RA
   Pianta, RC
   Marsland, AL
   Slavich, GM
   Thomas, AS
   Yeung, WS
   Booth-LaForce, C
AF Bleil, Maria E.
   Roisman, Glenn, I
   Gregorich, Steven E.
   Appelhans, Bradley M.
   Hiatt, Robert A.
   Pianta, Robert C.
   Marsland, Anna L.
   Slavich, George M.
   Thomas, Alexis S.
   Yeung, Winnie S.
   Booth-LaForce, Cathryn
TI Thirty-year follow-up of the NICHD Study of Early Child Care and Youth
   Development (SECCYD): the challenges and triumphs of conducting
   in-person research at a distance
SO BMJ OPEN
LA English
DT Article
DE EPIDEMIOLOGY; MENTAL HEALTH; PREVENTIVE MEDICINE; PUBLIC HEALTH; SOCIAL
   MEDICINE; CARDIOLOGY
ID EARLY-LIFE ADVERSITY; CAUSE-SPECIFIC MORTALITY; UNITED-STATES;
   SOCIOECONOMIC CIRCUMSTANCES; CARDIOVASCULAR-DISEASE; SOCIAL
   DETERMINANTS; ATTACHMENT SECURITY; METABOLIC-SYNDROME; EARLY MENARCHE;
   RISK-FACTORS
AB Purpose The purpose of the current study, The National Institute of Child Health and Human Development (NICHD) Study of Health in Early and Adult Life (SHINE), was to build on the landmark Study of Early Child Care and Youth Development (SECCYD), a longitudinal birth cohort initiated in 1991, by conducting a health-focused follow-up of the now adult participants. This effort has produced an invaluable resource for the pursuit of life course research examining links between early life risk and resilience factors and adulthood health and disease risk.
   Participants Of the 927 NICHD SECCYD participants available for recruitment in the current study, 705 (76.1%) participated in the study. Participants were between 26 and 31 years and living in diverse geographic locations throughout the USA.
   Findings to date 'In descriptive analyses, the sample exhibited risk on health status indicators, especially related to obesity, hypertension and diabetes. Of particular concern, the prevalence of hypertension (29.4%) and diabetes (25.8%) exceeded national estimates in similar-age individuals. Health behaviour indicators generally tracked with the parameters of poor health status, showing a pattern of poor diet, low activity and disrupted sleep. The juxtaposition of the sample's relatively young age (mean=28.6 years) and high educational status (55.6% college educated or greater) with its poor health status is noteworthy, suggesting a dissociation between health and factors that are typically health protective. This is consistent with observed population health trends, which show a worsening of cardiometabolic health status in younger generations of Americans.
   Future plans The current study, SHINE, lays the groundwork for future analyses in which the uniquely robust measures collected as a part of the original NICHD SECCYD will be leveraged to pinpoint specific early life risk and resilience factors as well as the correlates and potential mechanisms accounting for variability in health and disease risk indicators in young adulthood.
C1 [Bleil, Maria E.; Thomas, Alexis S.; Yeung, Winnie S.; Booth-LaForce, Cathryn] Univ Washington, Dept Child Family & Populat Hlth Nursing, Seattle, WA 98195 USA.
   [Roisman, Glenn, I] Univ Minnesota Twin Cities, Inst Child Dev, Minneapolis, MN USA.
   [Gregorich, Steven E.] Univ Calif San Francisco, Sch Med, Dept Med, San Francisco, CA USA.
   [Appelhans, Bradley M.] Rush Univ, Dept Prevent Med, Med Ctr, Chicago, IL 60612 USA.
   [Hiatt, Robert A.] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA USA.
   [Pianta, Robert C.] Univ Virginia, Sch Educ & Human Dev, Charlottesville, VA USA.
   [Marsland, Anna L.] Univ Pittsburgh, Dept Psychol, Pittsburgh, PA 15260 USA.
   [Slavich, George M.] Univ Calif Los Angeles, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90024 USA.
C3 University of Washington; University of Washington Seattle; University
   of Minnesota System; University of Minnesota Twin Cities; University of
   California System; University of California San Francisco; Rush
   University; University of California System; University of California
   San Francisco; University of Virginia; Pennsylvania Commonwealth System
   of Higher Education (PCSHE); University of Pittsburgh; University of
   California System; University of California Los Angeles
RP Bleil, ME (corresponding author), Univ Washington, Dept Child Family & Populat Hlth Nursing, Seattle, WA 98195 USA.
EM mbleil@uw.edu
RI Slavich, George/C-6208-2008; Hiatt, Robert/AAQ-1537-2021
OI Slavich, George/0000-0001-5710-3818
FU Eunice Kennedy Shriver National Institute of Child Health and Human
   Development [U10HD025447, R01HD091132]; National Heart, Lung, and Blood
   Institute at the National Institutes of Health [R01HL130103]
FX This work was supported by the Eunice Kennedy Shriver National Institute
   of Child Health and Human Development (U10HD025447, R01HD091132) and the
   National Heart, Lung, and Blood Institute (R01HL130103) at the National
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   US Department of Agriculture, FOOD NUTR SERV HLTH
   Vandell DL, 2010, CHILD DEV, V81, P737, DOI 10.1111/j.1467-8624.2010.01431.x
   Wegman HL, 2009, PSYCHOSOM MED, V71, P805, DOI 10.1097/PSY.0b013e3181bb2b46
   Widén E, 2012, DIABETES CARE, V35, P850, DOI 10.2337/dc11-1365
   Young ES, 2021, DEV PSYCHOPATHOL, V33, P301, DOI 10.1017/S0954579419001779
   Young ES, 2019, PSYCHOL SCI, V30, P739, DOI 10.1177/0956797619833664
NR 77
TC 5
Z9 5
U1 0
U2 3
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2044-6055
J9 BMJ OPEN
JI BMJ Open
PD FEB
PY 2023
VL 13
IS 3
AR e066655
DI 10.1136/bmjopen-2022-066655
PG 16
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA G8ZO7
UT WOS:000991974800046
PM 36940940
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Meulendijks, ER
   Roelofs, MJM
   de Vries, TAC
   Wesselink, R
   Al-Shama, RFM
   van Boven, WJP
   Driessen, AHG
   Berger, WR
   de Jong, JSSG
   de Groot, JR
AF Meulendijks, Eva R.
   Roelofs, Manouck J. M.
   de Vries, Tim A. C.
   Wesselink, Robin
   Al-Shama, Rushd F. M.
   van Boven, Wim-Jan P.
   Driessen, Antoine H. G.
   Berger, Wouter R.
   de Jong, Jonas S. S. G.
   de Groot, Joris R.
TI Obese patients exhibit a greater enhancement in mental health-related
   quality of life compared to non-obese patients following thoracoscopic
   ablation of atrial fibrillation
SO FRONTIERS IN CARDIOVASCULAR MEDICINE
LA English
DT Article
DE obesity; atrial fibillation; quality of life; ablation; thoracoscopic;
   SF36 health survey
ID BODY-MASS INDEX; GANGLION PLEXUS ABLATION; PULMONARY VEIN ISOLATION;
   CATHETER ABLATION; METABOLIC SYNDROME; RECURRENCE; IMPACT; METAANALYSIS;
   WEIGHT; BRAIN
AB Background Obesity is an important risk factor for atrial fibrillation (AF) development and progression. Furthermore, obesity reduces health-related quality of life (HRQoL), an essential indicator for treatment efficacy of AF ablation. Nevertheless, the extent to which obesity influences changes in HRQoL and the recurrence of AF following ablation, especially thoracoscopic AF ablation, remains largely unexplored. Aims We assessed in obese vs. non-obese patients undergoing thoracoscopic AF ablation: (1) HRQoL upon ablation, (2) AF recurrence incidence, (3) the association between recurrence incidence and HRQoL. Methods & results 408 prospectively enrolled patients were included for analysis. Heart rhythm was systematically monitored during follow-up. AF recurrence was defined as any atrial tachyarrhythmia episode > 30 s. HRQoL and recurrence incidence were assessed for normal weight (BMI <= 24.9 kg/m(2)), overweight (25.0-29.9 kg/m(2)) and obese (>= 30.0 kg/m(2)) patients. HRQoL was assessed at baseline and 1-year follow-up. Obese patients scored lower in pre-operative HRQoL across 6/8 subscales vs. non-obese patients (p < 0.01-0.05). While HRQoL increased in all patients, obese patients showed a trend towards an even greater improvement of mental HRQoL (p = 0.07) vs. non- obese patients. In obesity, mental HRQoL increased similarly for those with and without AF recurrence (p = 0.78), whereas in non-obese patients, AF recurrence was associated with less improved mental HRQoL (p = 0.03). AF recurrence at 1-year was similar between all weight groups (72.4%, 68.0%, 70.4%, p = 0.69). Conclusions After thoracoscopic ablation, obese patients experience a comparable incidence of AF recurrence as non-obese patients. Interestingly, obese patients also exhibit a more significant enhancement in mental quality of life, regardless of whether AF recurs or not.
C1 [Meulendijks, Eva R.; Roelofs, Manouck J. M.; de Vries, Tim A. C.; Wesselink, Robin; Al-Shama, Rushd F. M.; van Boven, Wim-Jan P.; Driessen, Antoine H. G.; de Groot, Joris R.] Univ Amsterdam, Amsterdam UMC, Heart Ctr, Dept Clin & Expt Cardiol, Amsterdam, Netherlands.
   [Meulendijks, Eva R.; Roelofs, Manouck J. M.; Wesselink, Robin; Al-Shama, Rushd F. M.; van Boven, Wim-Jan P.; Driessen, Antoine H. G.; de Groot, Joris R.] Univ Amsterdam, Amsterdam UMC, Heart Ctr, Dept Cardiothorac Surg, Amsterdam, Netherlands.
   [Meulendijks, Eva R.; Roelofs, Manouck J. M.; Wesselink, Robin; Al-Shama, Rushd F. M.; van Boven, Wim-Jan P.; Driessen, Antoine H. G.; de Groot, Joris R.] Amsterdam Cardiovasc Sci, Amsterdam, Netherlands.
   [de Vries, Tim A. C.] Rijnstate Ziekenhuis, Dept Cardiol, Arnhem, Netherlands.
   [Berger, Wouter R.; de Jong, Jonas S. S. G.] OLVG, Dept Cardiol, Amsterdam, Netherlands.
C3 University of Amsterdam; University of Amsterdam; Rijnstate Hospital;
   Onze Lieve Vrouwe Gasthuis Hospital
RP de Groot, JR (corresponding author), Univ Amsterdam, Amsterdam UMC, Heart Ctr, Dept Clin & Expt Cardiol, Amsterdam, Netherlands.; de Groot, JR (corresponding author), Univ Amsterdam, Amsterdam UMC, Heart Ctr, Dept Cardiothorac Surg, Amsterdam, Netherlands.; de Groot, JR (corresponding author), Amsterdam Cardiovasc Sci, Amsterdam, Netherlands.
EM j.r.degroot@amsterdamumc.nl
RI Al-Shama, Rushd/AFS-2224-2022; de Groot, Joris/M-3282-2017; de Vries,
   Tim A.C./AAY-6431-2020
OI de Vries, Tim A.C./0000-0003-1392-8193
FU CVON/Dutch Heart Foundation [EmbRACE 01-002-2022-0118]; Information
   Technology for European Advancement-ITEA4 [21026]; Atricure; Bayer;
   Boston Scientific; Daiichi Sankyo; Johnson Johnson; Medtronic;
   Population Health Research Institute
FX The author(s) declarefinancial support was received for theresearch,
   authorship, and/or publication of this article. This workis supported by
   CVON/Dutch Heart Foundation grant EmbRACE 01-002-2022-0118 and by
   Information Technology for European Advancement-ITEA4 grant 21026. JG
   receivedresearch grants through his institution from Atricure, Bayer,
   Boston Scientific, Daiichi Sankyo, Johnson&Johnson and Medtronic, and
   honoraria/speakers fees from Atricure, Bayer,Biotronik, Daiichi Sankyo,
   Medtronic, Novartis, Servier. W-JBand AD are consultant for Atricure. TV
   reports nonfinancialsupport from Daiichi Sankyo, and speaker fees from
   bothBristol-Myers-Squibb and speakers bureaus; all outside thecurrent
   work. He also reports that is he is being considered forthe adjudication
   committee of the LIMIT & DANCE trials,which are sponsored by the
   Population Health Research Institute.
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NR 45
TC 0
Z9 0
U1 0
U2 0
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2297-055X
J9 FRONT CARDIOVASC MED
JI Front. Cardiovasc. Med.
PD MAR 4
PY 2025
VL 12
AR 1433790
DI 10.3389/fcvm.2025.1433790
PG 9
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 0GP1O
UT WOS:001446878600001
PM 40104146
OA gold
DA 2025-06-11
ER

PT J
AU Dadvand, P
   Poursafa, P
   Heshmat, R
   Motlagh, ME
   Qorbani, M
   Basagaña, X
   Kelishadi, R
AF Dadvand, Payam
   Poursafa, Parinaz
   Heshmat, Ramin
   Motlagh, Mohammad Esmaeil
   Qorbani, Mostafa
   Basagana, Xavier
   Kelishadi, Roya
TI Use of green spaces and blood glucose in children; a population-based
   CASPIAN-V study
SO ENVIRONMENTAL POLLUTION
LA English
DT Article
DE Natural environment; Ecosystem services; Diabetes; Metabolic syndrome;
   Built environment; Park; Middle east
ID AIR-POLLUTION; BEHAVIORAL-DEVELOPMENT; SURROUNDING GREENNESS;
   NATURAL-ENVIRONMENT; INSULIN-RESISTANCE; MENTAL-HEALTH; RISK-FACTOR;
   EXPOSURE; ASSOCIATION; INEQUALITIES
AB A limited but emerging body of evidence is suggestive for a beneficial association between contact with green spaces and glucose homeostasis in adults; however, such an evidence for children is scarce. We evaluated the association between time spent in green spaces and fasting blood glucose (FBG) levels and impaired fasting glucose (IFG, FBG >= 110 mg/dL) in a population-based multicentric sample of 3844 Iranian schoolchildren aged 7-18 years (2015). Participants were instructed to report the average hours per week spent in green spaces separately during each season and in each type of green space (parks, woods/other natural green spaces, and private gardens/agricultural field) for a 12-month period preceding the interview. We developed linear and logistic mixed effects models with centre as random effect to evaluate the association of time spent in green spaces (separately for each type as well as all types together) with FBG and IFG, respectively, controlled for a wide range of covariates including household indicators of socioeconomic status. We observed inverse associations between time spent in green spaces, especially in natural green spaces, and FBG levels. Specifically, 1.83 h increase in the total time spent in green spaces was associated with -0.5 mg/dl (95% confidence intervals: -0.9, -0.1) change in FBG levels. We also observed reduced risk of IFG associated with time spent in green spaces; however, the association was statistically significant only for the time spent in natural green spaces. There were suggestions for stronger associations for those residing in urban areas and those from lower socioeconomic status groups; however, the interaction terms for socioeconomic status and urbanity were not statistically significant. Further longitudinal studies are required to replicate our findings in other settings with different climates and population susceptibilities. (C) 2018 Elsevier Ltd. All rights reserved.
C1 [Dadvand, Payam; Basagana, Xavier] ISGlobal, Doctor Aiguader 88, Barcelona 08003, Catalonia, Spain.
   [Dadvand, Payam; Basagana, Xavier] UPF, Barcelona, Spain.
   [Dadvand, Payam; Basagana, Xavier] CIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain.
   [Poursafa, Parinaz] Isfahan Univ Med Sci, Environm Res Ctr, Res Inst Primordial Prevent Noncommunicable Dis, Esfahan, Iran.
   [Heshmat, Ramin] Univ Tehran Med Sci, Chron Dis Res Ctr, Endocrinol & Metab Populat Sci Inst, Tehran, Iran.
   [Motlagh, Mohammad Esmaeil] Ahvaz Jundishapur Univ Med Sci, Dept Pediat, Ahvaz, Iran.
   [Qorbani, Mostafa] Alborz Univ Med Sci, Noncommunicable Dis Res Ctr, Karaj, Iran.
   [Kelishadi, Roya] Isfahan Univ Med Sci, Child Growth & Dev Res Ctr, Res Inst Primordial Prevent Noncommunicable Dis, Hezarjerib Ave, Esfahan, Iran.
C3 ISGlobal; Pompeu Fabra University; CIBER - Centro de Investigacion
   Biomedica en Red; CIBERESP; Isfahan University of Medical Sciences;
   Tehran University of Medical Sciences; Ahvaz Jundishapur University of
   Medical Sciences (AJUMS); Alborz University of Medical Sciences; Isfahan
   University of Medical Sciences
RP Dadvand, P (corresponding author), ISGlobal, Doctor Aiguader 88, Barcelona 08003, Catalonia, Spain.; Kelishadi, R (corresponding author), Isfahan Univ Med Sci, Child Growth & Dev Res Ctr, Res Inst Primordial Prevent Noncommunicable Dis, Hezarjerib Ave, Esfahan, Iran.
EM payam.dadvand@isglobal.org; kroya@aap.net
RI Heshmat, Ramin/S-7435-2017; motlagh, Mohammad/AAC-2653-2019; Kelishadi,
   Roya/E-6154-2012; Qorbani, Mostafa/M-8171-2017; poursafa,
   parinaz/U-2924-2017; Dadvand, Payam/O-8053-2018; Basagana,
   Xavier/C-3901-2017
OI Dadvand, Payam/0000-0002-2325-1027; motlagh, mohammad
   esmaiel/0000-0002-2971-8660; Basagana, Xavier/0000-0002-8457-1489
FU Ramon y Cajal fellowship - Spanish Ministry of Economy and Enterprise
   [RYC-2012-10995]
FX The study was conducted on the data obtained in a national surveillance
   program in Iran. Payam Dadvand is funded by a Ramon y Cajal fellowship
   (RYC-2012-10995) awarded by the Spanish Ministry of Economy and
   Enterprise.
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NR 55
TC 31
Z9 32
U1 0
U2 34
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 0269-7491
EI 1873-6424
J9 ENVIRON POLLUT
JI Environ. Pollut.
PD DEC
PY 2018
VL 243
BP 1134
EP 1140
DI 10.1016/j.envpol.2018.09.094
PN B
PG 7
WC Environmental Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology
GA HA0IW
UT WOS:000449892700038
PM 30261453
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Mhango, SN
   Kalimbira, A
   Mwagomba, B
AF Mhango, S. N.
   Kalimbira, A.
   Mwagomba, B.
TI Anthropometric characteristics and the burden of altered nutritional
   status among neuropsychiatric patients at Zomba Mental Hospital in
   Zomba, Malawi
SO MALAWI MEDICAL JOURNAL
LA English
DT Article
ID METABOLIC SYNDROME; SCHIZOPHRENIA; INDIVIDUALS; PREVALENCE; OBESITY;
   ALCOHOL; HEALTH; LIFE
AB Objective
   To determine the prevalence of overnutrition and undernutrition among neuropsychiatric inpatients and outpatients at Zomba Mental Hospital in Zomba, Malawi.
   Methods
   In this analytical cross-sectional study (n = 239), data were collected from psychiatric patients who were either inpatients (n = 181) or outpatients (n = 58) at Zomba Mental Hospital, which is the largest mental health facility in Malawi. Information was collected about patient demographics, anthropometric data, dietary information, and tobacco and alcohol use, among other variables. Data were entered and analysed in SPSS 16.0 (SPSS Inc., Chicago, IL, USA). Means were generated and compared between male and female patients, and between inpatients and outpatients.
   Results
   The study recruited 158 male and 81 female patients, with mean ages of 31.24 +/- 11.85 years and 33.08 +/- 15.18 years (p = 0.328), respectively. Male patients were significantly taller (165.27 +/- 7.25 cm) than female patients (155.30 +/- 6.56 cm) (p < 0.001); were significantly heavier than females (60.02 +/- 10.56 kg versus 55.64 +/- 10.53 kg); and had a significantly lower mean body mass index (BMI) than females (21.87 +/- 3.21 vs. 23.01 +/- 3.78) (p = 0.016). Overweight and obese patients comprised 17.6% of the participants, and 8.8% were underweight. There were no significant differences in the prevalence of overweight, obesity, and underweight between male and female participants, or between inpatients and outpatients.
   Conclusion
   Our study-the first one of its kind in Malawi-characterised the anthropometry of neuropsychiatric patients at a major metal health facility in Malawi, and has shown a high proportion of overweight patients and a notable presence of underweight patients among them. Being overweight or obese is a risk factor for metabolic disorders. Being underweight may aggravate mental illness or disturb the effect of medication. There is need, therefore, to include nutrition screening and therapeutic or supplementary feeding as part of a comprehensive care and treatment plan for neuropsychiatric patients.
C1 [Mhango, S. N.; Kalimbira, A.] Lilongwe Univ Agr & Nat Resources LUANAR, Dept Human Nutr & Hlth, Lilongwe, Malawi.
   [Mwagomba, B.] Govt Malawi, Minist Hlth, Directorate Clin Serv, Noncommunicable Dis & Mental Hlth Unit, Lilongwe, Malawi.
C3 Lilongwe University of Agriculture & Natural Resources
RP Mhango, SN (corresponding author), Lilongwe Univ Agr & Nat Resources LUANAR, Dept Human Nutr & Hlth, Lilongwe, Malawi.
OI Kalimbira, Alexander Archippus/0009-0000-9771-5093
FU United States Agency for International Development (USAID), through an
   academic scholarship
FX We thank the members of staff at Zomba Mental Hospital, especially Mr.
   Michael Udedi (Mental Health Officer) who made the data collection a lot
   easier than we expected. This work was supported by the United States
   Agency for International Development (USAID), through an academic
   scholarship.
CR Allison DB, 2009, PSYCHIAT RES, V170, P172, DOI 10.1016/j.psychres.2008.10.007
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NR 25
TC 5
Z9 5
U1 0
U2 3
PU MED COLL MALAWI
PI CHICHIRI
PA MALAWAI MEDICAL JOURNAL, PRIVATE BAG 360, CHICHIRI, BLANTYRE 3 00000,
   MALAWI
SN 1995-7262
EI 1995-7270
J9 MALAWI MED J
JI Malawi Med. J.
PD JUN
PY 2015
VL 27
IS 2
BP 41
EP 44
DI 10.4314/mmj.v27i2.2
PG 4
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA CP5UZ
UT WOS:000359951800002
PM 26405510
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Thorndike, AN
   Achtyes, ED
   Cather, C
   Pratt, S
   Pachas, GN
   Hoeppner, SS
   Evins, AE
AF Thorndike, Anne N.
   Achtyes, Eric D.
   Cather, Corinne
   Pratt, Sarah
   Pachas, Gladys N.
   Hoeppner, Susanne S.
   Evins, A. Eden
TI Weight Gain and 10-Year Cardiovascular Risk With Sustained Tobacco
   Abstinence in Smokers With Serious Mental Illness: A Subgroup Analysis
   of a Randomized Trial
SO JOURNAL OF CLINICAL PSYCHIATRY
LA English
DT Article
ID CATIE SCHIZOPHRENIA TRIAL; SMOKING-CESSATION; BIPOLAR DISORDER;
   DOUBLE-BLIND; METABOLIC SYNDROME; DIABETES-MELLITUS; EXCESS MORTALITY;
   PRIMARY-CARE; LIFE-STYLE; INDIVIDUALS
AB Objective: People with serious mental illness die earlier than those without mental illness, largely from cardiovascular disease due to high rates of smoking and obesity. The objective of this study was to determine whether the metabolic effects of postcessation weight gain among smokers with serious mental illness attenuated the cardiovascular benefit of tobacco abstinence.
   Method: A subgroup analysis was conducted of 65 outpatient smokers with DSM-IV diagnosis of schizophrenia, schizoaffective disorder, or bipolar disorder from 10 community mental health centers in 6 states who enrolled between March 2008-April 2012 and completed a trial of varenicline for tobacco abstinence. The intervention included a 12-week open-label phase with varenicline followed by a 40-week randomized, placebo-controlled phase in 87 participants who achieved 12-week abstinence. Main outcome measures were smoking status and change from baseline in weight and 10-year Framingham cardiovascular risk score at end of intervention (week 52).
   Results: At week 52, 65 participants completed follow-up (33 abstinent; 32 relapsed). At baseline, the 2 groups did not differ in body mass index (mean = 31 kg/m(2)), blood pressure, serum glucose, or diagnoses of diabetes (31%) and hypertension (34%). Abstinent participants were older and had a higher mean baseline Framingham risk score (14.2% vs 10.3%, P = .002). At week 52, abstinent participants gained more weight than relapsed participants (4.8 vs 1.2 kg, P = .048) and, as a result of quitting smoking, had a greater reduction in Framingham risk score (-7.6% vs 0.0%, P < .001). There was no effect of study drug assignment on weight or Framingham risk score.
   Conclusions: Sustained tobacco abstinence reduced 10-year cardiovascular risk in outpatients with serious mental illness despite significant postcessation weight gain and high prevalence of obesity, diabetes, and hypertension. (C) Copyright 2016 Physicians Postgraduate Press, Inc.
C1 [Thorndike, Anne N.] Massachusetts Gen Hosp, Dept Med, Boston, MA 02114 USA.
   [Thorndike, Anne N.; Cather, Corinne; Pachas, Gladys N.; Hoeppner, Susanne S.; Evins, A. Eden] Harvard Med Sch, Boston, MA USA.
   [Achtyes, Eric D.] Cherry Hlth, Grand Rapids, MI USA.
   [Achtyes, Eric D.] Michigan State Univ, Coll Human Med, Grand Rapids, MI USA.
   [Cather, Corinne; Pachas, Gladys N.; Hoeppner, Susanne S.; Evins, A. Eden] Massachusetts Gen Hosp, Dept Psychiat, Boston, MA 02114 USA.
   [Pratt, Sarah] Dartmouth Coll, Geisel Sch Med, Hanover, NH USA.
C3 Harvard University; Harvard University Medical Affiliates; Massachusetts
   General Hospital; Harvard University; Harvard Medical School; Michigan
   State University; Michigan State University College of Human Medicine;
   Harvard University; Harvard University Medical Affiliates; Massachusetts
   General Hospital; Dartmouth College
RP Thorndike, AN (corresponding author), Massachusetts Gen Hosp, 50 Staniford St,9th Fl, Boston, MA 02114 USA.
EM athorndike@partners.org
RI Thorndike, Anne/R-6291-2019; Hoeppner, Susanne S./C-4631-2015; Achtyes,
   Eric/M-6024-2016
OI Thorndike, Anne/0000-0003-1096-9221; Hoeppner, Susanne
   S./0000-0003-2060-1666; Achtyes, Eric/0000-0001-8939-1535
FU National Institute on Drug Abuse [R01 DA021245, K24 DA030443]; Pfizer
FX This study was funded by grant R01 DA021245 by National Institute on
   Drug Abuse with supplemental financial and material support from an
   investigator-initiated award from Pfizer for study medications and
   project funding. Drs Evins and Hoeppner were supported by grant K24
   DA030443 from the National Institute on Drug Abuse.
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NR 61
TC 19
Z9 19
U1 1
U2 10
PU PHYSICIANS POSTGRADUATE PRESS
PI MEMPHIS
PA P O BOX 752870, MEMPHIS, TN 38175-2870 USA
SN 0160-6689
EI 1555-2101
J9 J CLIN PSYCHIAT
JI J. Clin. Psychiatry
PD MAR
PY 2016
VL 77
IS 3
BP E320
EP E326
DI 10.4088/JCP.15m10074
PG 7
WC Psychology, Clinical; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA DQ5LC
UT WOS:000379245700008
PM 27046320
DA 2025-06-11
ER

PT J
AU Zhou, X
   Niu, JM
   Ji, WJ
   Zhang, ZL
   Wang, PP
   Ling, XFB
   Li, YM
AF Zhou, Xin
   Niu, Jian-Min
   Ji, Wen-Jie
   Zhang, Zhuoli
   Wang, Peizhong P.
   Ling, Xue-Feng B.
   Li, Yu-Ming
TI Precision test for precision medicine: opportunities, challenges and
   perspectives regarding pre-eclampsia as an intervention window for
   future cardiovascular disease
SO AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
LA English
DT Review
DE Pre-eclampsia; hypertensive disorders in pregnancy; cardiovascular risk;
   precision medicine; cardiac stress test
ID ISCHEMIC-HEART-DISEASE; ELEVATION MYOCARDIAL-INFARCTION;
   CORONARY-ARTERY-DISEASE; HYPERTENSIVE DISORDERS; BLOOD-PRESSURE;
   SEX-DIFFERENCES; SODIUM-INTAKE; PREGNANCY COMPLICATIONS; METABOLIC
   SYNDROME; GENETIC-VARIANTS
AB Hypertensive disorders of pregnancy (HDP) comprise a spectrum of syndromes that range in severity from gestational hypertension and pre-eclamplsia (PE) to eclampsia, as well as chronic hypertension and chronic hypertension with superimposed PE. HDP occur in 2% to 10% of pregnant women worldwide, and impose a substantial burden on maternal and fetal/infant health. Cardiovascular disease (CVD) is the leading cause of death in women. The high prevalence of non-obstructive coronary artery disease and the lack of an efficient diagnostic workup make the identification of CVD in women challenging. Accumulating evidence suggests that a previous history of PE is consistently associated with future CVD risk. Moreover, PE as a maladaptation to pregnancy-induced hemodynamic and metabolic stress may also be regarded as a "precision" testing result that predicts future cardiovascular risk. Therefore, the development of PE provides a tremendous, early opportunity that may lead to changes in maternal and infant future well-being. However, the underlying pathogenesis of PE is not precise, which warrants precision medicine-based approaches to establish a more precise definition and reclassification. In this review, we proposed a stage-specific, PE-targeted algorithm, which may provide novel hypotheses that bridge the gap between Big Data-generating approaches and clinical translational research in terms of PE prediction and prevention, clinical treatment, and long-term CVD management.
C1 [Zhou, Xin; Ji, Wen-Jie; Li, Yu-Ming] Logist Univ, PAPF, Pingjin Hosp,Heart Ctr, Tianjin Key Lab Cardiovasc Remodeling & Target Or, Tianjin 300162, Peoples R China.
   [Niu, Jian-Min] Guangdong Women & Children Hosp, Guangzhou 511400, Guangdong, Peoples R China.
   [Zhang, Zhuoli] Northwestern Univ, Feinberg Sch Med, Dept Radiol, Chicago, IL 60611 USA.
   [Wang, Peizhong P.] Mem Univ Newfoundland, Fac Med, 300 Prince Phillip Dr, St John, NF A1C 5S7, Canada.
   [Ling, Xue-Feng B.] Stanford Univ, Dept Surg, Palo Alto, CA 94305 USA.
C3 Northwestern University; Feinberg School of Medicine; Memorial
   University Newfoundland; Stanford University
RP Zhou, X; Li, YM (corresponding author), Pingjin Hosp, Ctr Heart, Tianjin Key Lab Cardiovasc Remodeling & Target Or, 220 Cheng Lin St, Tianjin 300162, Peoples R China.
EM xzhou@live.com; cardiolab@live.com
RI wang, peter/AAD-5851-2020; Zhou, Xin/AAH-7351-2019; JI,
   WENJIE/H-1274-2015
OI Zhou, Xin/0000-0003-1395-7103; Ling, Bruce/0000-0002-5386-3884
FU National Natural Science Foundation of China [81170238, 81570335]; China
   Scholarship Council; Tianjin Municipal Science and Technology Commission
   Key Funding [15ZXJZSY00010]
FX This work was supported by research grants from National Natural Science
   Foundation of China to Dr. Z.X and Dr. Y-M.L (81170238 and 81570335) and
   China Scholarship Council and Tianjin Municipal Science and Technology
   Commission Key Funding to Dr. Y-M.L (15ZXJZSY00010).
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NR 98
TC 13
Z9 16
U1 0
U2 17
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 1943-8141
J9 AM J TRANSL RES
JI Am. J. Transl. Res.
PY 2016
VL 8
IS 5
BP 1920
EP 1934
PG 15
WC Oncology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Research & Experimental Medicine
GA DN5HI
UT WOS:000377096800001
PM 27347303
DA 2025-06-11
ER

PT J
AU Gupta, H
   Bhandari, U
AF Gupta, Himani
   Bhandari, Uma
TI Molecular Insight into Obesity-Associated Nephropathy: Clinical
   Implications and Possible Strategies for its Management
SO CURRENT DRUG TARGETS
LA English
DT Review
DE Obesity; chronic kidney disease; insulin resistance; inflammation; lipid
   metabolism
ID CHRONIC KIDNEY-DISEASE; X-RECEPTOR-ALPHA; WEIGHT-LOSS; METABOLIC
   SYNDROME; OXIDATIVE STRESS; INFLAMMATORY STRESS; LIPID-ACCUMULATION;
   RENAL INFLAMMATION; BARIATRIC SURGERY; BLOOD-PRESSURE
AB Obesity is a significant health concern due to its rapid increase worldwide. It has been linked to the pathogenic factors of renal diseases, cancer, cardiovascular diseases, hypertension, dyslipidemia, and type 2 diabetes. Notably, obesity raises the likelihood of developing chronic kidney disease (CKD), leading to higher adult mortality and morbidity rates. This study explores the molecular mechanisms that underlie obesity-associated nephropathy and its clinical implications. Obesity-Associated Nephropathy (OAN) develops and worsens due to insulin resistance and hyperinsulinemia, which promote renal sodium reabsorption, glomerular hyperfiltration, and hypertension, leading to progressive kidney damage. Renal damage is further aggravated by persistent inflammation and redox damage, mediated by adipokines and proinflammatory cytokines, such as TNF-alpha and IL-6. Furthermore, stimulation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) intensifies glomerular hypertension and fibrosis. These elements cause glomerular hyperfiltration, renal hypertrophy, and progressive kidney damage. Clinical manifestations of obesity-associated nephropathy include proteinuria, reduced glomerular filtration rate (GFR), and ultimately, CKD. Management strategies currently focus on lifestyle modifications, such as weight loss through diet and exercise, which have been effective in reducing proteinuria and improving GFR. Pharmacological treatments targeting metabolic pathways, including GLP-1 receptor agonists and SGLT2 inhibitors, have shown renoprotective properties. Additionally, traditional RAAS inhibitors offer therapeutic benefits. Early detection and comprehensive management of OAN are essential to prevent its progression and lessen the burden of CKD.
C1 [Gupta, Himani; Bhandari, Uma] Jamia Hamdard, Sch Pharmaceut Educ & Res SPER, Dept Pharmacol, New Delhi 110062, India.
C3 Jamia Hamdard University
RP Bhandari, U (corresponding author), Jamia Hamdard, Sch Pharmaceut Educ & Res SPER, Dept Pharmacol, New Delhi 110062, India.
EM ubhandari@jamiahamdard.ac.in
RI Bhandari, Uma/GPX-1103-2022
FX Declared none.
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NR 118
TC 1
Z9 1
U1 1
U2 1
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1389-4501
EI 1873-5592
J9 CURR DRUG TARGETS
JI Curr. Drug Targets
PY 2025
VL 26
IS 3
BP 188
EP 202
DI 10.2174/0113894501314788241008115712
EA SEP 2024
PG 15
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA X1S9M
UT WOS:001333089600001
PM 39411934
DA 2025-06-11
ER

PT J
AU Nilsson, C
   Larsson, BM
   Jennische, E
   Eriksson, E
   Björntorp, P
   York, DA
   Holmäng, A
AF Nilsson, C
   Larsson, BM
   Jennische, E
   Eriksson, E
   Björntorp, P
   York, DA
   Holmäng, A
TI Maternal endotoxemia results in obesity and insulin resistance in adult
   male offspring
SO ENDOCRINOLOGY
LA English
DT Article
ID SEXUALLY DIMORPHIC NUCLEUS; PITUITARY-ADRENAL AXIS;
   CENTRAL-NERVOUS-SYSTEM; ABDOMINAL OBESITY; LEPTIN RECEPTOR; PREOPTIC
   AREA; BODY-WEIGHT; FEMALE RATS; IN-VIVO; STRESS
AB Events in utero appear to be important factors contributing to the development of somatic disorders at adult age. The aim of this study was to examine whether maternal immune challenge would be followed at adult age by metabolic and endocrine abnormalities in the offspring. Pregnant rats were given injections of either endotoxin (Escherichia coli lipopolysaccharide; 0.79 mg/kg, ip) or vehicle on days 8, 10, and 12 of gestation. Adult male offspring to lipopolysaccharide-exposed dams were heavier than controls (P < 0.05) and showed increased adipose tissue weights (P < 0.05), elevated food intake (P < 0.05), and increased circulating leptin (P < 0.01). The effect of insulin on glucose uptake was reduced, as measured by an euglycemic hyperinsulinemic clamp technique (P < 0.05). Serum levels of 17 beta -estradiol and progesterone were elevated (P < 0.01 and P < 0.05, respectively). Baseline levels of corticosterone were normal, but the corticosterone response to stress was attenuated (P < 0.05), and hippocampal glucocorticoid receptor protein was up-regulated (P < 0.05). Female offspring were uninfluenced, except for increased testosterone levels (P < 0.05), increased baseline corticosterone levels (P < 0.05), and enlargement of heart and adrenals (P < 0.05). The results indicate that maternal endotoxemia leads to obesity, insulin resistance, and high serum levels of leptin in the adult male offspring. This study reports a novel animal model of obesity with features of the metabolic syndrome.
C1 Gothenburg Univ, Wallenberg Lab, S-41345 Gothenburg, Sweden.
   Gothenburg Univ, Dept Heart & Lung Dis, S-41345 Gothenburg, Sweden.
   Gothenburg Univ, Dept Histol, S-41345 Gothenburg, Sweden.
   Gothenburg Univ, Dept Pharmacol, S-41345 Gothenburg, Sweden.
   Louisiana State Univ, Pennington Biomed Res Ctr, Baton Rouge, LA 70808 USA.
C3 University of Gothenburg; University of Gothenburg; University of
   Gothenburg; University of Gothenburg; Louisiana State University System;
   Louisiana State University; Pennington Biomedical Research Center
RP Gothenburg Univ, Wallenberg Lab, S-41345 Gothenburg, Sweden.
EM cecilia.nilsson@wlab.wall.gu.se
FU NIDDK NIH HHS [DK 28997] Funding Source: Medline
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NR 48
TC 79
Z9 88
U1 0
U2 5
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0013-7227
EI 1945-7170
J9 ENDOCRINOLOGY
JI Endocrinology
PD JUN
PY 2001
VL 142
IS 6
BP 2622
EP 2630
DI 10.1210/en.142.6.2622
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 435VP
UT WOS:000168903100058
PM 11356713
OA Bronze
DA 2025-06-11
ER

PT J
AU Primo, D
   Rioja, JG
   Izaola, O
   San Cristóbal, CD
   Teno, RP
   Román, DD
AF Primo, David
   Garcia Rioja, Javier
   Izaola, Olatz
   del Rio San Cristobal, Carlos
   Pinero Teno, Ruben
   de Luis Roman, Daniel
TI Real-world study of an online platform for the prescription of physical
   exercise to obese patients Effect on anthropometric, biochemical
   parameters and quality of life
SO NUTRICION HOSPITALARIA
LA English
DT Article
DE Real world study; Physical exercise; Obesity; Online platform
ID BODY-COMPOSITION; RESISTANCE EXERCISE; WEIGHT-LOSS; INTENSITY; INTERVAL;
   GLUCOSE; MUSCLE; ADULTS; ANGIOGENESIS; CHOLESTEROL
AB Introduction: one of the risk factors related to obesity is a sedentary lifestyle. Physical exercise produces metabolic benefits. Its prescription through online tools has been poorly evaluated, though.
   Objective: the objective of our study was to assess the effect of the prescription of physical exercise through an online platform on anthropometric parameters, cardiovascular risk factors, and quality of life in sedentary obese patients.
   Material and methods: in a total of 35 obese patients, anthropometric data, muscle mass by ultrasound at the quadriceps level, laboratory parameters, blood pressure, and quality of life using the SF36 tool were collected at baseline and at 12 weeks. For 12 weeks, a structured physical exercise program was prescribed through an online platform - www.vibraup.com.
   Results: after the physical exercise program with the online platform, there was a significant improvement in body mass index (-1.51 +/- 0.1 kg/ m(2); p = 0.01), weight (-3.7 +/- 0.6 kg; p = 0.01), waist circumference (-6.9 +/- 0.3 cm; p = 0.01), fat mass (-3.9 +/- 0.2 kg; p = 0.01), muscle mass (5.5 +/- 1.6 kg; p = 0.01), diastolic blood pressure (-4.5 +/- 0.4 mm Hg; p = 0.01), insulin (-2.8 +/- 0.1 IU/L; p = 0.04), and insulin resistance (HOMA-IR) (-0.9 +/- 0.1 units; p = 0.03). The ultrasound parameters of the anterior rectus muscle also improved significantly. The prevalence of metabolic syndrome decreased from 27.3 % to 12.1 % (p = 0.03). The SF36 quality of life test showed a significant improvement in general health (20.9 +/- 4.1 points; p = 0.001), physical role (6.9 +/- 0.9 points; p = 0.01), and mental health (14.0 +/- 1.3 points; p = 0.01).
   Conclusion: the prescription of physical exercise with an online platform to obese patients improves weight, decreases body fat mass and increases muscle mass, with a decrease in insulin resistance and an improvement in quality of life.
C1 [Primo, David; Garcia Rioja, Javier; Izaola, Olatz; de Luis Roman, Daniel] Univ Valladolid, Fac Med, Ctr Invest Endocrinol & Nutr Clin, Av Ramon y Cajal 7, Valladolid 47003, Spain.
   [Primo, David; Izaola, Olatz; de Luis Roman, Daniel] Univ Valladolid, Hosp Univ Valladolid, Serv Endocrinol & Nutr, Valladolid, Spain.
   [Garcia Rioja, Javier; del Rio San Cristobal, Carlos; Pinero Teno, Ruben] Ctr Vibia, Valladolid, Spain.
C3 Universidad de Valladolid; Universidad de Valladolid; University
   Hospital of Valladolid
RP Román, DD (corresponding author), Univ Valladolid, Fac Med, Ctr Invest Endocrinol & Nutr Clin, Av Ramon y Cajal 7, Valladolid 47003, Spain.
EM dadluis@yahoo.es
RI de luis roman, Daniel/HKN-3846-2023
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NR 37
TC 1
Z9 1
U1 2
U2 6
PU ARAN EDICIONES, S L
PI MADRID
PA C/ CASTELLO, 128, 1O, MADRID, 28006, SPAIN
SN 0212-1611
EI 1699-5198
J9 NUTR HOSP
JI Nutr. Hosp.
PD MAR-APR
PY 2022
VL 39
IS 2
BP 337
EP 347
DI 10.20960/nh.03842
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 3F3BO
UT WOS:000830544300013
PM 35068165
DA 2025-06-11
ER

PT J
AU Gong, M
   Antony, S
   Sakurai, R
   Liu, J
   Iacovino, M
   Rehan, VK
AF Gong, M.
   Antony, S.
   Sakurai, R.
   Liu, J.
   Iacovino, M.
   Rehan, V. K.
TI Bone marrow mesenchymal stem cells of the intrauterine growth-restricted
   rat offspring exhibit enhanced adipogenic phenotype
SO INTERNATIONAL JOURNAL OF OBESITY
LA English
DT Article
ID MATERNAL FOOD RESTRICTION; ADIPOSE-TISSUE; ADIPOCYTE DIFFERENTIATION;
   METABOLIC SYNDROME; LUNG DEVELOPMENT; OBESITY; PREADIPOCYTES;
   EXPRESSION; OSTEOBLAST; NUTRITION
AB OBJECTIVE: Although intrauterine nutritional stress is known to result in offspring obesity and the metabolic phenotype, the underlying cellular/molecular mechanisms remain incompletely understood. We tested the hypothesis that compared with the controls, the bone marrow-derived mesenchymal stem cells (BMSCs) of the intrauterine growth-restricted (IUGR) offspring exhibit a more adipogenic phenotype.
   METHODS: A well-established rat model of maternal food restriction (MFR), that is, 50% global caloric restriction during the later-half of pregnancy and ad libitum diet following birth that is known to result in an obese offspring with a metabolic phenotype was used. BMSCs at 3 weeks of age were isolated, and then molecularly and functionally profiled.
   RESULTS: BMSCs of the intrauterine nutritionally-restricted offspring demonstrated an increased proliferation and an enhanced adipogenic molecular profile at miRNA, mRNA and protein levels, with an overall up-regulated PPAR gamma (miR-30d, miR-103, PPAR gamma, C/EPB alpha, ADRP, LPL, SREBP1), but down-regulated Wnt (LRP5, LEF-1, beta-catenin, ZNF521 and RUNX2) signaling profile. Following adipogenic induction, compared with the control BMSCs, the already up-regulated adipogenic profile of the MFR BMSCs, showed a further increased adipogenic response.
   CONCLUSIONS: Markedly enhanced adipogenic molecular profile and increased cell proliferation of MFR BMSCs suggest a possible novel cellular/mechanistic link between the intrauterine nutritional stress and offspring metabolic phenotype. This provides new potential predictive and therapeutic targets against these conditions in the IUGR offspring.
C1 [Gong, M.; Antony, S.; Sakurai, R.; Liu, J.; Iacovino, M.; Rehan, V. K.] David Geffen Sch Med, Harbor UCLA Med Ctr, Los Angeles Biomed Res Inst, Neonatal Intens Care Unit,Dept Pediat, Torrance, CA USA.
C3 University of California System; University of California Los Angeles;
   University of California Los Angeles Medical Center; David Geffen School
   of Medicine at UCLA; Lundquist Institute
RP Rehan, VK (corresponding author), Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles Biomed Res Inst, Neonatal Intens Care Unit,Dept Pediat,Harbor UCLA, 1124 West Carson St, Torrance, CA 90502 USA.
EM vrehan@labiomed.org
OI iacovino, michelina/0000-0002-1076-3146
FU NIH [HD058948, HL107118, HD071731, HD127237]; TRDRP [17RT-0170,
   23RT-0018]
FX This research was funded by grants from the NIH (HD058948, HL107118,
   HD071731, HD127237) and the TRDRP (17RT-0170, and 23RT-0018). The
   authors had full access to all of the data and take responsibility for
   the integrity of the data and the accuracy of analysis.
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NR 37
TC 15
Z9 15
U1 0
U2 11
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0307-0565
EI 1476-5497
J9 INT J OBESITY
JI Int. J. Obes.
PD NOV
PY 2016
VL 40
IS 11
BP 1768
EP 1775
DI 10.1038/ijo.2016.157
PG 8
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA EC4TT
UT WOS:000388127600024
PM 27599633
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Streja, E
   Kovesdy, CP
   Streja, DA
   Moradi, H
   Kalantar-Zadeh, K
   Kashyap, ML
AF Streja, Elani
   Kovesdy, Csaba P.
   Streja, Dan A.
   Moradi, Hamid
   Kalantar-Zadeh, Kamyar
   Kashyap, Moti L.
TI Niacin and Progression of CKD
SO AMERICAN JOURNAL OF KIDNEY DISEASES
LA English
DT Review
DE Niacin; chronic kidney disease; HDL function; hyperphosphatemia;
   cardiovascular disease; phosphorus absorption
ID CHRONIC KIDNEY-DISEASE; DENSITY-LIPOPROTEIN CHOLESTEROL;
   EXTENDED-RELEASE NIACIN; TYPE-2 DIABETES-MELLITUS;
   GLOMERULAR-FILTRATION-RATE; BLOOD-PRESSURE CONTROL; CHRONIC
   RENAL-DISEASE; PULSE-WAVE VELOCITY; METABOLIC SYNDROME; OXIDATIVE STRESS
AB Niacin is the oldest drug available for the treatment of dyslipidemia. It has been studied extensively and tested in clinical trials of atherosclerotic cardiovascular disease prevention and regression in the general population, but not specifically in patients with chronic kidney disease (CKD), who are at extremely high residual risk despite current therapy. Despite the current controversy about recent trials with niacin, including their limitations, there may be a place for this agent in select patients with CKD with dyslipidemia. Niacin has a favorable unique impact on factors affecting the rate of glomerular filtration rate decline, including high-density lipoprotein (HDL) particle number and function, triglyceride levels, oxidant stress, inflammation and endothelial function, and lowering of serum phosphorus levels by reducing dietary phosphorus absorption in the gastrointestinal tract. These effects may slow glomerular filtration rate decline and ultimately improve CKD outcomes and prevent cardiovascular risk. This review presents the clinically relevant concept that niacin holds significant potential as a renoprotective therapeutic agent. In addition, this review concludes that clinical investigations to assess the effect of niacin (in addition to aggressive low-density lipoprotein cholesterol lowering) on reduction of cardiovascular events in patients with CKD with very low HDL cholesterol (or those with identified dysfunctional HDL) and elevated triglyceride levels need to be considered seriously to address the high residual risk in this population. (C) 2015 by the National Kidney Foundation, Inc.
C1 [Streja, Elani; Moradi, Hamid; Kalantar-Zadeh, Kamyar] Univ Calif Irvine, Med Ctr, Div Nephrol & Hypertens, Harold Simmons Ctr Kidney Dis Res & Epidemiol, Orange, CA 92868 USA.
   [Kovesdy, Csaba P.] Memphis Vet Affairs Med Ctr, Nephrol Sect, Memphis, TN USA.
   [Kovesdy, Csaba P.] Univ Tennessee, Ctr Hlth Sci, Div Nephrol, Memphis, TN 38163 USA.
   [Streja, Dan A.] Infosphere Clin Res, West Hills, England.
   [Streja, Dan A.] Providence Med Grp, West Hills, England.
   [Kalantar-Zadeh, Kamyar; Kashyap, Moti L.] Univ Calif Irvine, Sch Med, Dept Med, Orange, CA 92868 USA.
   [Kashyap, Moti L.] Long Beach Veteran Affairs Healthcare Syst, Atherosclerosis Res Ctr, Long Beach, CA USA.
C3 University of California System; University of California Irvine; US
   Department of Veterans Affairs; Veterans Health Administration (VHA);
   Memphis VA Medical Center; University of Tennessee System; University of
   Tennessee Health Science Center; University of California System;
   University of California Irvine; US Department of Veterans Affairs;
   Veterans Health Administration (VHA); VA Long Beach Healthcare System
RP Streja, E (corresponding author), Univ Calif Irvine, Med Ctr, Div Nephrol & Hypertens, Harold Simmons Ctr Kidney Dis Res & Epidemiol, 101 City Dr,City Tower,Ste 424, Orange, CA 92868 USA.
EM estreja@uci.edu; moti.kashyap@va.gov
RI Kalantar-Zadeh, Kamyar/Q-4734-2018
OI Kashyap, Moti/0000-0002-0052-8302; Kalantar-Zadeh,
   Kamyar/0000-0002-8666-0725
FU Abbvie; AstraZeneca; Sanofi-Aventis; Merck; Eli-Lilly; Amgen; Amylin;
   Arisaph
FX Drs Kovesdy, Kalantar-Zadeh, and Kashyap are employees of the US
   Department of Veterans Affairs. Opinions expressed in this article are
   those of the authors and do not necessarily represent the opinion of the
   Department of Veterans Affairs. Dr Kashyap currently has research grant
   support as Principal Investigator (PI) or sub-PI through the VA from
   Abbvie, AstraZeneca, Sanofi-Aventis, Merck, Eli-Lilly, Amgen, Amylin,
   and Arisaph. The remaining authors state that they have no relevant
   financial interests.
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NR 175
TC 29
Z9 31
U1 0
U2 14
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0272-6386
EI 1523-6838
J9 AM J KIDNEY DIS
JI Am. J. Kidney Dis.
PD MAY
PY 2015
VL 65
IS 5
BP 785
EP 798
DI 10.1053/j.ajkd.2014.11.033
PG 14
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA CL1SA
UT WOS:000356723300022
PM 25708553
OA Green Published
DA 2025-06-11
ER

PT J
AU Matravadia, S
   Herbst, EAF
   Jain, SS
   Mutch, DM
   Holloway, GP
AF Matravadia, Sarthak
   Herbst, Eric A. F.
   Jain, Swati S.
   Mutch, David M.
   Holloway, Graham P.
TI Both linoleic and α-linolenic acid prevent insulin resistance but have
   divergent impacts on skeletal muscle mitochondrial bioenergetics in
   obese Zucker rats
SO AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
LA English
DT Article
DE linoleic acid; alpha-linoleic acid; polyunsaturated fatty acids; insulin
   resistance; mitochondria
ID POLYUNSATURATED FATTY-ACIDS; INTERMYOFIBRILLAR MITOCHONDRIA; PALMITATE
   OXIDATION; METABOLIC SYNDROME; FISH-OIL; IN-VIVO; N-3; SENSITIVITY;
   INFLAMMATION; TRANSPORT
AB The therapeutic use of polyunsaturated fatty acids (PUFA) in preserving insulin sensitivity has gained interest in recent decades; however, the roles of linoleic acid (LA) and alpha-linolenic acid (ALA) remain poorly understood. We investigated the efficacy of diets enriched with either LA or ALA on attenuating the development of insulin resistance (IR) in obesity. Following a 12-wk intervention, LA and ALA both prevented the shift toward an IR phenotype and maintained muscle-specific insulin sensitivity otherwise lost in obese control animals. The beneficial effects of ALA were independent of changes in skeletal muscle mitochondrial content and oxidative capacity, as obese control and ALA-treated rats showed similar increases in these parameters. However, ALA increased the propensity for mitochondrial H2O2 emission and catalase content within whole muscle and reduced markers of oxidative stress (4-HNE and protein carbonylation). In contrast, LA prevented changes in markers of mitochondrial content, respiratory function, H2O2 emission, and oxidative stress in obese animals, thereby resembling levels seen in lean animals. Together, our data suggest that LA and ALA are efficacious in preventing IR but have divergent impacts on skeletal muscle mitochondrial content and function. Moreover, we propose that LA has value in preserving insulin sensitivity in the development of obesity, thereby challenging the classical view that n-6 PUFAs are detrimental.
C1 [Matravadia, Sarthak; Herbst, Eric A. F.; Jain, Swati S.; Mutch, David M.; Holloway, Graham P.] Univ Guelph, Dept Human Hlth & Nutr Sci, Guelph, ON N1G 2W1, Canada.
C3 University of Guelph
RP Holloway, GP (corresponding author), Univ Guelph, 491 Gordon St, Guelph, ON N1G 2W1, Canada.
EM ghollowa@uoguelph.ca
OI Mutch, David/0000-0002-0908-7259
FU Ontario Ministry of Agriculture, Food, and Rural Affairs
FX This work was funded by the Ontario Ministry of Agriculture, Food, and
   Rural Affairs, and infrastructure was purchased with the assistance of
   the Canadian Foundation for Innovation as well as the Ontario Research
   Fund.
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NR 56
TC 38
Z9 42
U1 1
U2 17
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0193-1849
EI 1522-1555
J9 AM J PHYSIOL-ENDOC M
JI Am. J. Physiol.-Endocrinol. Metab.
PD JUL 1
PY 2014
VL 307
IS 1
BP E102
EP E114
DI 10.1152/ajpendo.00032.2014
PG 13
WC Endocrinology & Metabolism; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Physiology
GA AL1WQ
UT WOS:000338917400010
PM 24844257
DA 2025-06-11
ER

PT J
AU Aversa, A
   Duca, Y
   Condorelli, RA
   Calogero, AE
   La Vignera, S
AF Aversa, Antonio
   Duca, Ylenia
   Condorelli, Rosita Angela
   Calogero, Aldo Eugenio
   La Vignera, Sandro
TI Androgen Deficiency and Phosphodiesterase Type 5 Expression Changes in
   Aging Male: Therapeutic Implications
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Review
DE aging; hypogonadism; erectile dysfunction; sexual desire; pde5
   expression; pde5 inhibitors; testosterone replacement therapy; elderly
ID ENDOTHELIAL PROGENITOR CELLS; ARTERIAL ERECTILE DYSFUNCTION; LATE-ONSET
   HYPOGONADISM; SERUM TESTOSTERONE LEVELS; NITRIC-OXIDE; METABOLIC
   SYNDROME; LEYDIG-CELLS; CORPUS CAVERNOSUM; OXIDATIVE STRESS;
   URINARY-BLADDER
AB The age-related decline of serum T occurs in similar to 20-30% of adult men and it is today defined as late-onset hypogonadism (LOH). In the elderly, such decline becomes more prevalent (up to 60%) and shows-up with erectile dysfunction (ED) and hypoactive sexual desire. A large body of experimental evidences have shown that the combination of T replacement therapy (TRT) and phosphodiesterase type 5 inhibitors (PDE5i) is, usually, effective in restoring erectile function in patients with LOH and ED who have not responded to monotherapy for sexual disturbances. In fact, PDE5is potentiate the action of nitric oxide (NO) produced by endothelial cells, resulting in a vasodilator effect, while T facilitates PDE5i effects by increasing the expression of PDE5 in corpora cavernosa. Meta-analytic data have recognized to PDE5i a protective role on the cardiovascular health in patients with decreased left ventricular ejection fraction. In addition, several studies have shown pleiotropic beneficial effects of these drugs throughout the body (i.e., on bones, urogenital tract and cerebral, metabolic, and cardiovascular levels). TRT itself is able to decrease endothelial dysfunction, oxidative stress and inflammation, thus lowering the cardiovascular risk. Furthermore, untreated hypogonadism could be the cause of PDE5i ineffectiveness especially in the elderly. For these reasons, aging men complaining ED who have LOH should undergo TRT before or at the moment when PDE5i treatment is started.
C1 [Aversa, Antonio] Magna Graecia Univ Catanzaro, Dept Expt & Clin Med, Catanzaro, Italy.
   [Duca, Ylenia; Condorelli, Rosita Angela; Calogero, Aldo Eugenio; La Vignera, Sandro] Univ Catania, Dept Clin & Expt Med, Catania, Italy.
C3 Magna Graecia University of Catanzaro; University of Catania
RP La Vignera, S (corresponding author), Univ Catania, Dept Clin & Expt Med, Catania, Italy.
EM sandrolavignera@unict.it
RI Duca, Ylenia/ABB-2042-2020; Calogero, Aldo/AAA-9538-2021; Aversa,
   Antonio/O-3151-2019; La Vignera, Sandro/AAR-1589-2020
OI La Vignera, Sandro/0000-0002-7113-2372; Duca,
   Ylenia/0000-0002-9923-3079; Condorelli, Rosita
   Angela/0000-0002-5217-9343
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NR 107
TC 22
Z9 22
U1 0
U2 5
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD APR 11
PY 2019
VL 10
AR 225
DI 10.3389/fendo.2019.00225
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA HT2EG
UT WOS:000464375400001
PM 31110491
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Al Zarzour, RH
   Ahmad, M
   Asmawi, MZ
   Kaur, G
   Saeed, MAA
   Al-Mansoub, MA
   Saghir, SAM
   Usman, NS
   Al-Dulaimi, DW
   Yam, MF
AF Al Zarzour, Raghdaa Hamdan
   Ahmad, Mariam
   Asmawi, Mohd Zaini
   Kaur, Gurjeet
   Saeed, Mohammed Ali Ahmed
   Al-Mansoub, Majed Ahmed
   Saghir, Sultan Ayesh Mohammed
   Usman, Nasiba Salisu
   Al-Dulaimi, Dhamraa W.
   Yam, Mun Fei
TI Phyllanthus Niruri Standardized Extract Alleviates the
   Progression of Non-Alcoholic Fatty Liver Disease and Decreases
   Atherosclerotic Risk in Sprague-Dawley Rats
SO NUTRIENTS
LA English
DT Article
DE Phyllanthus niruri; non-alcoholic fatty liver disease (NAFLD); insulin
   resistance; atherosclerosis; alpha-glucosidase; pancreatic lipase;
   cholesterol micellization; ellagic acid; phyllanthin
ID OXIDATIVE STRESS; ANTIOXIDANT ACTIVITIES; HEPATIC STEATOSIS; IN-VITRO;
   METABOLIC SYNDROME; CHOLESTEROL; EZETIMIBE; NAFLD; ACIDS; DIET
AB Non-alcoholic fatty liver disease (NAFLD) is one of the major global health issues, strongly correlated with insulin resistance, obesity and oxidative stress. The current study aimed to evaluate anti-NAFLD effects of three different extracts of Phyllanthus niruri (P. niruri). NAFLD was induced in male Sprague-Dawley rats using a special high-fat diet (HFD). A 50% methanolic extract (50% ME) exhibited the highest inhibitory effect against NAFLD progression. It significantly reduced hepatomegaly (16%) and visceral fat weight (22%), decreased NAFLD score, prevented fibrosis, and reduced serum total cholesterol (TC) (48%), low-density lipoprotein (LDL) (65%), free fatty acids (FFAs) (25%), alanine aminotransferase (ALT) (45%), alkaline phosphatase (ALP) (38%), insulin concentration (67%), homeostatic model assessment of insulin resistance (HOMA-IR) (73%), serum atherogenic ratios TC/high-density lipoprotein (HDL) (29%), LDL/HDL (66%) and (TC-HDL)/HDL (64%), hepatic content of cholesterol (43%), triglyceride (29%) and malondialdehyde (MDA) (40%) compared to a non-treated HFD group. In vitro, 50% ME of P. niruri inhibited alpha-glucosidase, pancreatic lipase enzymes and cholesterol micellization. It also had higher total phenolic and total flavonoid contents compared to other extracts. Ellagic acid and phyllanthin were identified as major compounds. These results suggest that P. niruri could be further developed as a novel natural hepatoprotective agent against NAFLD and atherosclerosis.
C1 [Al Zarzour, Raghdaa Hamdan; Ahmad, Mariam; Asmawi, Mohd Zaini; Al-Mansoub, Majed Ahmed; Saghir, Sultan Ayesh Mohammed; Usman, Nasiba Salisu; Al-Dulaimi, Dhamraa W.; Yam, Mun Fei] Univ Sains Malaysia, Discipline Pharmacol, Sch Pharmaceut Sci, George Town 11800, Malaysia.
   [Kaur, Gurjeet] Univ Sains Malaysia, Inst Res Mol Med INFORMM, George Town 11800, Malaysia.
   [Saeed, Mohammed Ali Ahmed] Univ Sains Malaysia, Discipline Pharmaceut Chem, Sch Pharmaceut Sci, George Town 11800, Malaysia.
C3 Universiti Sains Malaysia; Universiti Sains Malaysia; Universiti Sains
   Malaysia
RP Al Zarzour, RH; Ahmad, M (corresponding author), Univ Sains Malaysia, Discipline Pharmacol, Sch Pharmaceut Sci, George Town 11800, Malaysia.
EM raghdaa.alzarzour@yahoo.com; mariam@usm.my; amzaini@usm.my;
   gurjeet@usm.my; mohali141@yahoo.com; madjed_25@yahoo.fr;
   sultan_a1976@yahoo.com; nasibausman@gmail.com; dhamora@yahoo.com;
   yammunfei@yahoo.com
RI Yam, Mun/E-2862-2012; Saghir, Sultan/B-3643-2017; Zarzour,
   Raghdaa/AAH-1018-2020; Kaur, Gurjeet/A-1085-2011; Saeed, Mohammed Ali
   Ahmed/S-4184-2018; Al-Mansoub, Majed Ahmed/N-7782-2018
OI Kaur, Gurjeet/0000-0002-6232-5703; Saeed, Mohammed Ali
   Ahmed/0000-0003-3914-6130; Asmawi, Mohd Zaini/0000-0003-0420-6797;
   Al-Mansoub, Majed Ahmed/0000-0003-0162-5830
FU School of Pharmaceutical Sciences, University Sains Malaysia;
   fundamental research grant scheme (FRGS), ministry of education,
   Malaysia [203/PFARMASI/6711451]
FX The researchers would like to thank the School of Pharmaceutical
   Sciences, University Sains Malaysia, for providing the necessary
   facility and financial support for this research. Special thanks go to
   Safia Akhtar Khan, Adlin Yousof, Bassel Al Hindi, Abdul Menem Bakory and
   Idiri Bello (USM Malaysia), Sawsan AL Madi, Ayman Ali (Damascus
   University), Issam Sabbagh and Wafiqa Zarzour from School of Pharmacy at
   Arab International University (AIU) for their great assistance. This
   work was in part supported by the fundamental research grant scheme
   (FRGS), ministry of education, Malaysia, No.: 203/PFARMASI/6711451.
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NR 71
TC 46
Z9 46
U1 1
U2 15
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JUL
PY 2017
VL 9
IS 7
AR 766
DI 10.3390/nu9070766
PG 19
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA FC2PF
UT WOS:000406679700122
PM 28718838
OA Green Published, Green Accepted, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Agaba, DC
   Migisha, R
   Lugobe, HM
   Katamba, G
   Ashaba, S
AF Agaba, David Collins
   Migisha, Richard
   Lugobe, Henry Mark
   Katamba, Godfrey
   Ashaba, Scholastic
TI A 10-Year Risk of Cardiovascular Disease among Patients with Severe
   Mental Illness at Mbarara Regional Referral Hospital, Southwestern
   Uganda
SO BIOMED RESEARCH INTERNATIONAL
LA English
DT Article
ID MAJOR DEPRESSIVE DISORDER; CORONARY-HEART-DISEASE; SYSTEMATIC ANALYSIS;
   METABOLIC SYNDROME; LIFETIME RISK; GLOBAL BURDEN; MORTALITY;
   SCHIZOPHRENIA; GUIDELINES; PEOPLE
AB Cardiovascular disease (CVD) is a leading cause of morbidity and mortality worldwide. Patients with severe mental illness (SMI) are at a higher risk for developing CVD and have a higher risk for harboring factors related to CVD. In addition to the effects of antipsychotic medications, unhealthy lifestyle factors, such as poor diet, inadequate physical activity, cigarette smoking, and sedentary behaviors, are known to be risk factors that may contribute to poor cardiovascular health in patients with SMI. Early identification of individuals at elevated risk of CVD is essential so that dietary and lifestyle modifications or pharmacological interventions can be prescribed to alleviate the risk of cardiovascular disease. The objective of the study was to determine the 10-year risk of cardiovascular disease among patients with severe mental illness at Mbarara Regional Referral Hospital, southwestern Uganda. We conducted a cross-sectional study at the outpatient mental health clinic of Mbarara Regional Referral Hospital, between October 2018 and March 2019. We used the Globorisk CVD risk score to estimate the 10-year risk of CVD among patients with SMI, using the online Globorisk calculator. Participants were then assigned to one of three categories depending on their 10-year CVD risk score: <3% (low), 3-10% (intermediate), and >10% (high). We calculated the risk scores of 125 participants aged 40-74 years. Most of the participants were female 75 (60%), had a diagnosis of bipolar disorder 75 (60%), and had mental illness for >= 10 years 57 (46%). Eighty five percent (85%) of the participants had intermediate to high 10-year risk of CVD (64% with intermediate and 21% with high risk). The average risk score was significantly higher in males compared to females, 8.82% versus 6.43%,p=0.016. We detected a high 10-year risk of CVD in a significant proportion of patients with SMI in southwestern Uganda. We recommend lifestyle modifications and pharmacological interventions to reverse risk or delay progression to CVD in this patient population.
C1 [Agaba, David Collins; Migisha, Richard] Mbarara Univ Sci & Technol, Dept Physiol, Mbarara, Uganda.
   [Lugobe, Henry Mark] Mbarara Univ Sci & Technol, Dept Obstet & Gynaecol, Mbarara, Uganda.
   [Katamba, Godfrey] King Ceasor Univ, Dept Physiol, Kampala, Uganda.
   [Ashaba, Scholastic] Mbarara Univ Sci & Technol, Dept Psychiat, Mbarara, Uganda.
   [Ashaba, Scholastic] Kampala Int Univ, Dept Psychiat, Kampala, Uganda.
C3 Mbarara University of Science & Technology; Mbarara University of
   Science & Technology; Mbarara University of Science & Technology
RP Agaba, DC (corresponding author), Mbarara Univ Sci & Technol, Dept Physiol, Mbarara, Uganda.
EM acollins@must.ac.ug
RI Katamba, Godfrey/AAF-6166-2020; Lugobe, Henry/AHC-7276-2022
OI Agaba, David Collins/0000-0002-7894-7611; Katamba,
   Godfrey/0000-0002-7456-0786
FU Mbarara University Research Training initiative, an NIH funded project;
   Fogarty International Center; NIH Common Fund, Office of Strategic
   Coordination, Office of the Director (OD/OSC/CF/NIH) of the National
   Institutes of Health [D43TW010128]; Office of AIDS Research, Office of
   the Director (OAR/NIH) of the National Institutes of Health
   [D43TW010128]; National Institute of Mental Health (NIMH/NIH) of the
   National Institutes of Health [D43TW010128]; National Institute of
   Neurological Disorders and Stroke (NINDS/NIH) of the National Institutes
   of Health [D43TW010128]
FX We thank all the patients who participated in the study and Mbarara
   Regional Referral Hospital administration for the administrative
   support. We are grateful to our research assistant Mr. Gerald Wakweyika
   and Mr. George Segutunga, the laboratory technician, for their immense
   contribution in data collection and analysis of the blood samples,
   respectively. Special thanks to Prof. Celestino Obua, the principal
   investigator of the Mbarara University Research Training initiative, an
   NIH funded project that funded this research. The research reported in
   this publication was supported by the Fogarty International Center and
   cofunding partners (NIH Common Fund, Office of Strategic Coordination,
   Office of the Director (OD/OSC/CF/NIH); Office of AIDS Research, Office
   of the Director (OAR/NIH); National Institute of Mental Health
   (NIMH/NIH); and National Institute of Neurological Disorders and Stroke
   (NINDS/NIH)) of the National Institutes of Health under Award Number
   D43TW010128.
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NR 35
TC 5
Z9 5
U1 0
U2 2
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2314-6133
EI 2314-6141
J9 BIOMED RES INT-UK
JI Biomed Res. Int.
PD JUL 24
PY 2020
VL 2020
AR 2508751
DI 10.1155/2020/2508751
PG 6
WC Biotechnology & Applied Microbiology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Biotechnology & Applied Microbiology; Research & Experimental Medicine
GA MZ3ZG
UT WOS:000559060500001
PM 32775412
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Wei, YZ
   Clark, SE
   Thyfault, JP
   Uptergrove, GME
   Li, WH
   Whaley-Connell, AT
   Ferrario, CM
   Sowers, JR
   Ibdah, JA
AF Wei, Yongzhong
   Clark, Suzanne E.
   Thyfault, John P.
   Uptergrove, Grace M. E.
   Li, Wenhan
   Whaley-Connell, Adam T.
   Ferrario, Carlos M.
   Sowers, James R.
   Ibdah, Jamal A.
TI Oxidative Stress-Mediated Mitochondrial Dysfunction Contributes to
   Angiotensin II-Induced Nonalcoholic Fatty Liver Disease in Transgenic
   Ren2 Rats
SO AMERICAN JOURNAL OF PATHOLOGY
LA English
DT Article
ID CYTOCHROME-C-OXIDASE; OBESE ZUCKER RATS; INSULIN-RESISTANCE; METABOLIC
   SYNDROME; HEPATIC STEATOSIS; ACID OXIDATION; STEATOHEPATITIS; MICE;
   INHIBITION; HYPERTENSION
AB Emerging evidence indicates that impaired mitochondrial fatty acid beta-oxidation plays a key role in liver steatosis. We have recently demonstrated that increased angiotensin (ANG) II causes progressive hepatic steatosis associated with oxidative stress; however, the underlying mechanisms remain unclear. We hypothesized that ANG II causes hepatic mitochondrial oxidative damage and impairs mitochondrial beta-oxidation, thereby leading to hepatic steatosis. We used the Ren2 rat with elevated endogenous ANG II levels to evaluate mitochondrial ultrastructural changes, gene expression levels, and beta-oxidation. Compared with Sprague-Dawley littermates, Rent livers exhibited mitochondrial damage and reduced beta-oxidation, as evidenced by ultrastructural abnormalities, decrease of mitochondrial content, percentage of palmitate oxidation to CO2, enzymatic activities (beta-HAD and citrate synthase), and the expression levels of cytochrome c, cytochrome c oxidase subunit 1, and mitochondria) transcription factor A. These abnormalities were improved with either ANG II receptor blocker valsartan or superoxide dismutase/catalase mimetic tempol treatment. Both valsartan and tempol substantially attenuated mitochondrial lipid peroxidation in Ren2 livers. Interestingly, there was no difference in the expression of key enzymes (ACC1 and FAS) for fatty acid syntheses and their transcription factors (SREBP-1c and ChREBP) between Sprague-Dawley, untreated Ren2, and valsartan- or tempol-treated Ren2 rats. These results document that ANG II induces mitochondrial oxidative damage and impairs mitochondrial beta-oxidation, contributing to liver steatosis. (Am J Pathol 2009, 174:1329-1337; DOI: 10.2353/ajpath.2009.080697)
C1 [Ibdah, Jamal A.] Univ Missouri, Div Gastroenterol & Hepatol, Dept Internal Med, Sch Med, Columbia, MO 65212 USA.
   [Wei, Yongzhong; Clark, Suzanne E.; Thyfault, John P.; Uptergrove, Grace M. E.; Li, Wenhan; Whaley-Connell, Adam T.; Sowers, James R.; Ibdah, Jamal A.] Harry Truman Vet Adm Med Ctr, Columbia, MO USA.
   [Ferrario, Carlos M.] Wake Forest Univ, Bowman Gray Sch Med, Winston Salem, NC USA.
C3 University of Missouri System; University of Missouri Columbia; US
   Department of Veterans Affairs; Veterans Health Administration (VHA);
   Harry S. Truman Memorial Veterans' Hospital; Wake Forest University;
   Wake Forest Baptist Medical Center
RP Ibdah, JA (corresponding author), Univ Missouri, Div Gastroenterol & Hepatol, Dept Internal Med, Sch Med, Columbia, MO 65212 USA.
EM ibdahj@health.missouri.edu
RI Ferrario, Carlos/ABD-2791-2020; Thyfault, John/JMB-3070-2023
OI Ferrario, Carlos M/0000-0003-0792-6239; Whaley-Connell,
   Adam/0000-0001-8955-5560; Thyfault, John/0000-0001-7920-7466; Ibdah,
   Jamal/0000-0002-5646-9014
FU National Institutes of Health [RO1-DK56345, RO1-HL073101]; Novartis
   Pharmaceutical Co.; University of Missouri Research Council
FX Supported in part by the National Institutes of Health (grants
   RO1-DK56345 to J.A.I. and RO1-HL073101 to J.R.S.), the Novartis
   Pharmaceutical Co. (to J.R.S.), and the University of Missouri Research
   Council (to Y.W.).
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NR 42
TC 57
Z9 60
U1 0
U2 10
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0002-9440
EI 1525-2191
J9 AM J PATHOL
JI Am. J. Pathol.
PD APR
PY 2009
VL 174
IS 4
BP 1329
EP 1337
DI 10.2353/ajpath.2009.080697
PG 9
WC Pathology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pathology
GA 425SQ
UT WOS:000264657800019
PM 19246643
OA Bronze, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Arslan, N
   Köksal, E
AF Arslan, Neslihan
   Koksal, Eda
TI Mediterranean diet and telomere length: aspects from obesity
SO NUTRITION & FOOD SCIENCE
LA English
DT Review
DE Telomere length; Mediterranean diet; Obesity; Oxidative stress
ID OXIDATIVE STRESS; METABOLIC SYNDROME; CIGARETTE-SMOKING; WEIGHT-LOSS;
   FOOD GROUPS; DNA-DAMAGE; LIFE-STYLE; ASSOCIATION; PATTERNS; CANCER
AB PurposeThe goal of this narrative review was to look at the link between the Mediterranean diet (MD) and the telomere length. Furthermore, this study aims to understand the impact of the MD on obesity-related telomere length.Design/methodology/approachRelevant literature was reviewed to explore the potential influence of the MD on telomere length and its association with obesity.FindingsThe MD is one of the healthiest diets of all known dietary patterns, and it is also linked to the telomere length. Except for fruits and vegetables, the main findings for other MD components are inconsistent. In terms of antioxidant and antiinflammatory properties, using the MD as a weight loss approach is a good method. For predicting changes in obesity characteristics, the initial telomere length is critical. However, there are not many studies in the field that have looked at the MD as a weight loss approach and its link to the telomere length. As a result, more research is needed to understand these connections in various groups.Originality/valueThis study is unique since it examines the MD, telomere length and obesity-related consequences. This study examines the MD, telomere length and obesity to determine if the MD can help lose weight while maintaining telomere length. As there are few studies on MD weight loss and telomere length, the work emphasizes the need for greater research in this area. This study fills a research gap and improves the understanding of nutrition, telomere biology and obesity-related outcomes.
C1 [Arslan, Neslihan; Koksal, Eda] Gazi Univ, Fac Hlth Sci, Dept Nutr & Dietet, Ankara, Turkiye.
C3 Gazi University
RP Arslan, N (corresponding author), Gazi Univ, Fac Hlth Sci, Dept Nutr & Dietet, Ankara, Turkiye.
EM akdeniz.neslihan91@gmail.com
RI ARSLAN, Neslihan/AAW-2874-2021; Koksal, Eda/AAW-2900-2021
FU Gazi University Scientific Research Projects Unit (BAP) [TDK-2021-7320]
FX The authors had support from Gazi University Scientific Research
   Projects Unit (BAP)(TDK-2021-7320).
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NR 84
TC 0
Z9 0
U1 1
U2 5
PU EMERALD GROUP PUBLISHING LTD
PI Leeds
PA Floor 5, Northspring 21-23 Wellington Street, Leeds, W YORKSHIRE,
   ENGLAND
SN 0034-6659
EI 1758-6917
J9 NUTR FOOD SCI
JI Nutr. Food Sci.
PD FEB 21
PY 2024
VL 54
IS 2
BP 302
EP 318
DI 10.1108/NFS-07-2023-0140
EA JAN 2024
PG 17
WC Food Science & Technology
WE Emerging Sources Citation Index (ESCI)
SC Food Science & Technology
GA IH4O4
UT WOS:001135819300001
DA 2025-06-11
ER

PT J
AU Jung, JH
   Kim, HS
AF Jung, Ji-Hye
   Kim, Hyun-Sook
TI The inhibitory effect of black soybean on hepatic cholesterol
   accumulation in high cholesterol and high fat diet-induced non-alcoholic
   fatty liver disease
SO FOOD AND CHEMICAL TOXICOLOGY
LA English
DT Article
DE Non-alcoholic fatty liver disease; Cholesterol accumulation; Insulin
   resistance; Antioxidative activity; Mice
ID INSULIN-RESISTANCE; METABOLIC SYNDROME; LIPID-METABOLISM; ABCA1
   EXPRESSION; SOY ISOFLAVONES; STRESS; RATS; MICE; PPAR; ROSIGLITAZONE
AB Non-alcoholic fatty liver disease (NAFLD) is defined as excess of fat in the liver. We investigated the effects of black soybean on the cholesterol metabolism and insulin resistance of mice fed high cholesterol/fat diets. Mice were randomly allocated into four groups that were fed different diets: the normal cholesterol/fat diet; high cholesterol/fat diets (HCD); and HCD with 1%, and 4% black soybean powder (1B-HCD, and 4B-HCD). Liver total cholesterol and triglyceride concentrations were significantly lower in the black soybean-supplemented groups than that in the HCD group. PCR revealed significantly lower hepatic SREBP2 and HMG-CoA reductase mRNA levels of black soybean-supplemented mice. Real-time PCR revealed significantly higher hepatic ABCA1 mRNA level of black soybean-supplemented mice, which may increase cholesterol efflux. Liver bile acids concentration was significantly high in the 4B-HCD group. Black soybean stimulated secretion of adiponectin, activation of pAMPK, and eliminated free fatty acids in the liver. Black soybean supplementation decreased MDA and nitrate level. The activities of SOD, catalase, and GPx were restored by black soybean supplementation. Our data strongly indicate that black soybean influences the balance between oxidative and antioxidative stress. We suggest that black soybean improves cholesterol metabolism, insulin resistance, and alleviates oxidative damage in NAFLD. Published by Elsevier Ltd.
C1 [Jung, Ji-Hye] Sookmyung Womens Univ, Coll Sci, Div Biol Sci, Seoul 140742, South Korea.
   [Kim, Hyun-Sook] Sookmyung Womens Univ, Coll Human Ecol, Seoul 140742, South Korea.
C3 Sookmyung Women's University; Sookmyung Women's University
RP Kim, HS (corresponding author), Sookmyung Womens Univ, Chungpa Dong 2 Ka,Sunhun Bldg 307, Seoul 140742, South Korea.
EM hskim@sookmyung.ac.kr
FU SRC Research Center for Women's Diseases of Sookmyung Women's
   University; BK 21
FX This work was supported by the SRC Research Center for Women's Diseases
   of Sookmyung Women's University (2011) and also supported by BK 21.
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NR 39
TC 43
Z9 49
U1 2
U2 49
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0278-6915
EI 1873-6351
J9 FOOD CHEM TOXICOL
JI Food Chem. Toxicol.
PD OCT
PY 2013
VL 60
BP 404
EP 412
DI 10.1016/j.fct.2013.07.048
PG 9
WC Food Science & Technology; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Toxicology
GA 228ZN
UT WOS:000325231700049
PM 23900008
DA 2025-06-11
ER

PT J
AU Prasad, F
   De, RDT
   Korann, V
   Chintoh, AF
   Remington, G
   Ebdrup, BH
   Siskind, D
   Knop, FK
   Vilsboll, T
   Fink-Jensen, A
   Hahn, MK
   Agarwal, SM
AF Prasad, Femin
   De, Riddhita
   Korann, Vittal
   Chintoh, Araba F.
   Remington, Gary
   Ebdrup, Bjorn H.
   Siskind, Dan
   Knop, Filip Krag
   Vilsboll, Tina
   Fink-Jensen, Anders
   Hahn, Margaret K.
   Agarwal, Sri Mahavir
TI Semaglutide for the treatment of antipsychotic-associated weight gain in
   patients not responding to metformin - a case series
SO THERAPEUTIC ADVANCES IN PSYCHOPHARMACOLOGY
LA English
DT Article
DE antipsychotics; metformin; obesity; semaglutide; severe mental illness
ID ONCE-WEEKLY SEMAGLUTIDE; PHASE 3A; OPEN-LABEL; DOUBLE-BLIND; ADD-ON;
   JAPANESE PATIENTS; DAILY SITAGLIPTIN; ORAL SEMAGLUTIDE; DIABETES CARE;
   DOUBLE-DUMMY
AB Metformin is the currently accepted first-line treatment for antipsychotic-associated weight gain (AAWG). However, not all patients benefit from metformin. Glucagon-like peptide-1 receptor agonists (GLP1-RA) have shown promise in the management of obesity in the general population, with preliminary evidence supporting efficacy in AAWG. Semaglutide is a weekly injectable GLP-1RA which received recent approval for obesity management and noted superiority over other GLP-1RAs. This study explored the efficacy and tolerability of semaglutide in AAWG among individuals with severe mental illness. A retrospective chart review of patients treated with semaglutide in the Metabolic Clinic at the Center for Addiction and Mental Health (CAMH) between 2019 and 2021 was conducted. Patients failing a trial of metformin (<5% weight loss or continuing to meet criteria for metabolic syndrome) after 3 months at the maximum tolerated dose (1500-2000 mg/day) were initiated on semaglutide up to 2 mg/week. The primary outcome measure was a change in weight at 3, 6, and 12 months. Twelve patients on weekly semaglutide injections of 0.71 +/- 0.47 mg/week were included in the analysis. About 50% were female; the average age was 36.09 +/- 13.32 years. At baseline, mean weight was 111.4 +/- 31.7 kg, BMI was 36.7 +/- 8.2 kg/m(2), with a mean waist circumference of 118.1 +/- 19.3 cm. A weight loss of 4.56 +/- 3.15 kg (p < 0.001), 5.16 +/- 6.27 kg (p = 0.04) and 8.67 +/- 9 kg (p = 0.04) was seen at 3, 6, and 12 months, respectively, after initiation of semaglutide with relatively well-tolerated side-effects. Initial evidence from our real-world clinical setting suggests that semaglutide may be effective in reducing AAWG in patients not responding to metformin. Randomized control trials investigating semaglutide for AAWG are needed to corroborate these findings.
C1 [Hahn, Margaret K.; Agarwal, Sri Mahavir] Ctr Addict & Mental Hlth, Schizophrenia Div, 1051 Queen St, Toronto, ON M6J 1H3, Canada.
   [Prasad, Femin; De, Riddhita; Korann, Vittal; Chintoh, Araba F.; Remington, Gary; Hahn, Margaret K.; Agarwal, Sri Mahavir] Univ Toronto, Inst Med Sci, Temerty Fac Med, Toronto, ON, Canada.
   [Chintoh, Araba F.; Remington, Gary; Hahn, Margaret K.; Agarwal, Sri Mahavir] Univ Toronto, Dept Psychiat, Toronto, ON, Canada.
   [Hahn, Margaret K.; Agarwal, Sri Mahavir] Univ Toronto, Banting & Best Diabet Ctr BBDC, Toronto, ON, Canada.
   [Prasad, Femin; De, Riddhita; Korann, Vittal; Chintoh, Araba F.; Remington, Gary] Ctr Addict & Mental Hlth CAMH, Schizophrenia Div, Toronto, ON, Canada.
   [Ebdrup, Bjorn H.; Knop, Filip Krag; Vilsboll, Tina; Fink-Jensen, Anders] Univ Copenhagen, Ctr Neuropsychiat Schizophrenia Res, Mental Hlth Ctr Glostrup, Glostrup, Denmark.
   [Ebdrup, Bjorn H.; Knop, Filip Krag; Vilsboll, Tina] Univ Copenhagen, Fac Hlth & Med Sci, Dept Clin Med, Copenhagen, Denmark.
   [Ebdrup, Bjorn H.] Univ Copenhagen, Gentofte Hosp, Ctr Clin Metab Res, Copenhagen, Denmark.
   [Ebdrup, Bjorn H.] Ctr Clin Intervent & Neuropsychiat Schizophrenia R, Glostrup, Denmark.
   [Siskind, Dan] Univ Queensland, Fac Med, Brisbane, Qld, Australia.
   [Siskind, Dan] Metro South Addict & Mental Hlth Serv, Brisbane, Qld, Australia.
   [Knop, Filip Krag; Vilsboll, Tina] Steno Diabet Ctr Copenhagen, Copenhagen, Denmark.
   [Knop, Filip Krag; Vilsboll, Tina] Univ Copenhagen, Novo Nord Fdn Ctr Basic Metab Res, Fac Hlth & Med Sci, Copenhagen, Denmark.
   [Fink-Jensen, Anders] Rigshosp, Psychiat Ctr Copenhagen, Mental Hlth Serv Capital Reg Denmark, Copenhagen, Denmark.
C3 University of Toronto; Centre for Addiction & Mental Health - Canada;
   University of Toronto; University of Toronto; University of Toronto;
   University of Toronto; Centre for Addiction & Mental Health - Canada;
   University of Copenhagen; University of Copenhagen; University of
   Copenhagen; Herlev & Gentofte Hospital; University of Queensland; Steno
   Diabetes Center; University of Copenhagen; University of Copenhagen;
   Copenhagen University Hospital; Rigshospitalet
RP Hahn, MK; Agarwal, SM (corresponding author), Ctr Addict & Mental Hlth, Schizophrenia Div, 1051 Queen St, Toronto, ON M6J 1H3, Canada.; Hahn, MK; Agarwal, SM (corresponding author), Univ Toronto, Inst Med Sci, Temerty Fac Med, Toronto, ON, Canada.; Hahn, MK; Agarwal, SM (corresponding author), Univ Toronto, Dept Psychiat, Toronto, ON, Canada.; Hahn, MK; Agarwal, SM (corresponding author), Univ Toronto, Banting & Best Diabet Ctr BBDC, Toronto, ON, Canada.
EM margaret.hahn@camh.ca; mahavir.agarwal@camh.ca
RI Vilsboll, Tina/I-6562-2016; Agarwal, Mahavir/ITV-3244-2023; Knop, Filip
   K/B-5130-2018; Hahn, Margaret/F-5034-2014; Ebdrup, Bjørn/P-8358-2018
OI De, Riddhita/0000-0002-8953-4716; Hahn, Margaret/0000-0001-8884-9946;
   Prasad, Femin/0000-0002-5445-2489
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NR 54
TC 30
Z9 30
U1 2
U2 6
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 2045-1253
EI 2045-1261
J9 THER ADV PSYCHOPHARM
JI Ther. Adv. Psychopharm.
PY 2023
VL 13
AR 20451253231165169
DI 10.1177/20451253231165169
PG 10
WC Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Psychiatry
GA G6MC9
UT WOS:000990267200001
PM 37113745
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Chang, HT
   Wu, CD
   Wang, JD
   Chen, PS
   Su, HJ
AF Chang, Hao-Ting
   Wu, Chih-Da
   Wang, Jung-Der
   Chen, Po-See
   Su, Huey-Jen
TI Residential green space structures are associated with a lower risk of
   bipolar disorder: A nationwide population-based study in Taiwan
SO ENVIRONMENTAL POLLUTION
LA English
DT Article
DE Green space structures; Greenness index; Bipolar disorder; Incidence;
   Frailty models
ID STRESSFUL LIFE EVENTS; MENTAL-HEALTH; PSYCHIATRIC-DISORDERS; LAND-COVER;
   ENVIRONMENT; AREAS; SCHIZOPHRENIA; PREVALENCE; MORTALITY; PROSPECT
AB Although many researchers have identified the potential psychological benefits offered by greenness, the association between green space structures and mental disorders is not well understood. The purpose of this study was to identify associations between green space structures and the incidence of bipolar disorder. To this end, we investigated 1,907,776 individuals collected from Taiwan's National Health Insurance Research Database. After a follow-up investigation from 2005 to 2016, among those with no history of bipolar disorder, 20,548 individuals were further found to be diagnosed with bipolar disorder. A geographic information system and landscape index were used to quantify three indices of green space structures: mean patch area (area and edge), mean fractal dimension index (shape), and mean proximity index (proximity). Additionally, greenness indices, the normalized difference vegetation index, and the enhanced vegetation index were used to confirm the association between greenness and incidence of bipolar disorder. These five indices were used to represent the individual's exposure according to the township of the hospital that they most frequently visited with symptoms of the common cold. Spearman's correlation analysis was performed to select variables by considering their collinearity. Subsequently, the frailty model for each index was used to examine the specific associations between those respective indices and the incidence of bipolar disorder by adjusting for related risk factors, such as socioeconomic status, metabolic syndrome, and air pollution. A negative association was identified between the mean patch area and the mean proximity index, and the incidence of bipolar disorder. In contrast, a positive association was found between the mean fractal dimension index and the incidence of bipolar disorder. We observed similar results in sensitivity testing and subgroup analysis. Exposure to green spaces with a larger area, greater proximity, lower complexity, and greener area may reduce the risk of bipolar disorder. (C) 2020 Elsevier Ltd. All rights reserved.
C1 [Chang, Hao-Ting; Su, Huey-Jen] Natl Cheng Kung Univ, Coll Med, Dept Environm & Occupat Hlth, Tainan 70101, Taiwan.
   [Wu, Chih-Da] Natl Cheng Kung Univ, Coll Engn, Dept Geomat, Tainan 70101, Taiwan.
   [Wu, Chih-Da] Natl Hlth Res Inst, Natl Inst Environm Hlth Sci, Miaoli 350, Taiwan.
   [Wang, Jung-Der] Natl Cheng Kung Univ, Coll Med, Dept Publ Hlth, Tainan 70101, Taiwan.
   [Chen, Po-See] Natl Cheng Kung Univ, Natl Cheng Kung Univ Hosp, Coll Med, Dept Psychiat, Tainan 70101, Taiwan.
   [Chen, Po-See] Natl Cheng Kung Univ, Coll Med, Inst Behav Med, Tainan 70101, Taiwan.
   [Chen, Po-See] Natl Cheng Kung Univ Hosp, Dou Liou Branch, Dept Psychiat, Touliu 64000, Yunlin, Taiwan.
C3 National Cheng Kung University; National Cheng Kung University; National
   Health Research Institutes - Taiwan; National Cheng Kung University;
   National Cheng Kung University; National Cheng Kung University Hospital;
   National Cheng Kung University; National Cheng Kung University; National
   Cheng Kung University Hospital
RP Su, HJ (corresponding author), Natl Cheng Kung Univ, Coll Med, Dept Environm & Occupat Hlth, Tainan 70101, Taiwan.
EM hjsu@mail.ncku.edu.tw
RI Chen, Po/AAA-6492-2021
OI Chang, Hao-Ting/0000-0001-8254-8923
FU Ministry of Science and Technology, Taiwan [MOST 107-2119-M-006-030];
   Ministry of Health and Welfare
FX This study was funded by the Ministry of Science and Technology, Taiwan
   (Grant no.: MOST 107-2119-M-006-030). The interpretation and conclusions
   contained herein do not represent those of the National Health Insurance
   Administration, Ministry of Health and Welfare.
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NR 96
TC 11
Z9 13
U1 3
U2 40
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0269-7491
EI 1873-6424
J9 ENVIRON POLLUT
JI Environ. Pollut.
PD AUG 15
PY 2021
VL 283
AR 115864
DI 10.1016/j.envpol.2020.115864
EA APR 2021
PG 12
WC Environmental Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology
GA SU4TR
UT WOS:000663132500007
PM 33857883
DA 2025-06-11
ER

PT J
AU Baykara, S
   Yilmaz, M
   Baykara, M
AF Baykara, Sema
   Yilmaz, Mucahit
   Baykara, Murat
TI QT dispersion and P wave dispersion in schizophrenia
SO PSYCHIATRY AND CLINICAL PSYCHOPHARMACOLOGY
LA English
DT Article
DE Schizophrenia; electrocardiography; heart function tests
ID METABOLIC SYNDROME; RISK-FACTORS; ANTIPSYCHOTIC-DRUGS; CARDIOVASCULAR
   RISK; DE-POINTES; INTERVAL; ABNORMALITIES; DISORDERS; SMOKING; PEOPLE
AB BACKGROUND: The difference between maximum QT (QTmax) and minimum (QTmin) on electrocardiography (ECG) is known as QT dispersion (QTd). An increase in QTd carries the risk of ventricular arrhythmia and subsequent death. P wave dispersion (Pd) shows the difference between maximum P (Pmax) and minimum P (Pmin). Prolonged P wave duration and an increase in Pd are a risk for irregular electrical transmission and atrial fibrillation.
   OBJECTIVES: The aim of this study was to examine QTd and Pd values which indicate atrial fibrillation and ventricular arrhythmia in schizophrenia patients with whom cardiovascular diseases (CVD) are seen at a higher rate than the general population.
   METHOD: The patient group consisted of 30 male patients diagnosed with schizophrenia according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) and receiving treatment either as inpatients or outpatients in the Mental Health and Diseases Hospital. The patient group had no other psychiatric, neurological or physical disease. The control group comprised 30 age-matched healthy males with no history of neurological, psychiatric, or physical disease.
   RESULTS: The cases in both groups were all males and there was no difference between the groups in respect of age. Corrected QTd was determined as 25.55 +/- 13.18 (ms) in the control group and 54.26 +/- 8.46 (ms) in the patient group (p<.001). Pd was determined as 36.22 +/- 10.08 (ms) in the control group and 46.32 +/- 5.87 (ms) in the patient group (p <.001). The differences in the values between the groups were statistically significant.
   DISCUSSIONS: The QTd and Pd values which show increased CVD risk were found to be significantly greater in schizophrenia patients than in the healthy control group. However, there is a need for further studies to determine whether this is a result of the nature of schizophrenia or the effect of the treatment drugs used. Thus, future studies could be planned to compare the QTd and Pd values of treated and untreated schizophrenia patients.
C1 [Baykara, Sema] Firat Univ, Sch Med, Dept Psychiat, Elazig, Turkey.
   [Yilmaz, Mucahit] Elazig Educ & Training Hosp, Elazig, Turkey.
   [Baykara, Murat] Firat Univ, Sch Med, Dept Radiol, Elazig, Turkey.
C3 Firat University; Elazig Training & Research Hospital; Firat University
RP Baykara, S (corresponding author), Firat Univ, Firat Tip Merkezi, Psikiyatri Anabilim Dali, TR-23119 Elazig, Turkey.
EM semabaykara@hotmail.com
RI Baykara, Sema/W-1080-2018; Yilmaz, Mucahid/NBY-4459-2025; Baykara,
   Murat/V-9081-2018
OI Baykara, Murat/0000-0003-2588-9013
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NR 35
TC 4
Z9 4
U1 0
U2 8
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 2475-0573
EI 2475-0581
J9 PSYCHIAT CLIN PSYCH
JI Psychiatry Clin. Psychopharmacol.
PD OCT 2
PY 2019
VL 29
IS 4
BP 538
EP 543
DI 10.1080/24750573.2018.1472906
PG 6
WC Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Psychiatry
GA KH4MJ
UT WOS:000510621700011
OA gold
DA 2025-06-11
ER

PT J
AU Qamar, H
   Mehmood, K
   Li, AY
   Waqas, M
   Iqbal, M
   Zhang, LH
   Tong, XL
   Li, JK
AF Qamar, Hammad
   Mehmood, Khalid
   Li, Aoyun
   Waqas, Muhammad
   Iqbal, Mudassar
   Zhang, Lihong
   Tong, Xiaole
   Li, Jiakui
TI Recovery of Chickens Affected with Tibial Dyschondroplasia by
   Application of Grape Seed Extract through Downregulating CA2 Gene and
   Enhancing Liver Functions
SO PAKISTAN VETERINARY JOURNAL
LA English
DT Article
DE Broiler; Carbonic anhydrase; Liver oxidative stress; Tibial
   dyschondroplasia lesion; Toxicity
ID OXIDATIVE STRESS; GROWTH-PLATE; PROANTHOCYANIDIN EXTRACT;
   IDENTIFICATION; ANGIOGENESIS; EXPRESSION; TOXICITY
AB Globally Tibial Dyschondroplasia (TD) is a serious metabolic syndrome in broilers that is identified by the accretion of the growth plate (GP) into the tibialmetaphyseal portion. Grape seed extract (GSE) is a well-known significant antioxidant since it possesses multifaceted anti-inflammatory, anti-cancer and reducing reactive oxygen ability. The experiment was intended to evaluate the proficiency of GSE to recover the chicks affected with TD. For this purpose, 210 chicks were bought and fed normal starter feed for the first 3 days. After that two groups were made having 70 (Control group; normal feed) and 140 chickens (Thiram group; normal feed+ thiram @ 50 mg/kg). Further two equal divisions were made in Thiram group on 7th day viz TD group and GSE group (@ 50 mg/kg/day). GSE significantly (P<0.05) reverted the blood serum profile and liver antioxidants metabolites and, reduced the histopathological abrasion of the liver as compared to the TD group. Furthermore, GSE chicks exhibited a significant decrease (P<0.05) in CA2 gene expression and less mortality, TD score and GP size. In inference, GSE is a natural plant-based extract which owns solid scavenging and bone healing property, and strong antioxidant capacity. GSE provided recovery to chicks affected with TD chicks via dropping TD score, whereas stabilized the GP width through the CA2 mRNA downregulation. (C)2019 PVJ. All rights reserved
C1 [Qamar, Hammad; Li, Jiakui] Tibet Agr & Anim Husb Univ, Coll Anim Husb & Vet Med, Linzhi 860000, Tibet, Peoples R China.
   [Qamar, Hammad; Mehmood, Khalid; Li, Aoyun; Waqas, Muhammad; Iqbal, Mudassar; Zhang, Lihong; Tong, Xiaole; Li, Jiakui] Huazhong Agr Univ, Coll Vet Med, Wuhan 430070, Hubei, Peoples R China.
   [Mehmood, Khalid; Iqbal, Mudassar] Islamia Univ Bahawalpur, Univ Coll Vet & Anim Sci, Bahawalpur 63100, Punjab, Pakistan.
   [Waqas, Muhammad] Univ Poonch, Fac Vet & Anim Sci, Dist Poonch 12350, Azad Jammu & Ka, Pakistan.
C3 Xizang Agricultural & Animal Husbandry University; Huazhong Agricultural
   University; Islamia University of Bahawalpur
RP Li, JK (corresponding author), Tibet Agr & Anim Husb Univ, Coll Anim Husb & Vet Med, Linzhi 860000, Tibet, Peoples R China.; Li, JK (corresponding author), Huazhong Agr Univ, Coll Vet Med, Wuhan 430070, Hubei, Peoples R China.
EM lijk210@sina.com
RI Li, Ao/GRR-5311-2022; Waqas, Muhammad/HTL-8680-2023; Li,
   Jiakui/HDN-1674-2022; Iqbal, Mudassir/GPS-7678-2022; MEHMOOD,
   KHALID/Y-5882-2019
OI Waqas, Dr. Muhammad/0000-0001-6576-3330; Zhang,
   Lihong/0009-0007-5341-576X; MEHMOOD, KHALID/0000-0003-4720-8792; Li,
   Jiakui/0000-0002-6065-6648; Qamar, Hammad/0009-0007-3571-5101
FU National Key Research and Development Program of China [2017YFD0502200];
   National Natural Science Foundation of China [31460682]
FX The authors would like to thank the lab mates and friends who helped in
   the slaughtering of chickens and buying the chickens and feed and
   support morally. The study was supported by the National Key Research
   and Development Program of China (Project No. 2017YFD0502200), and the
   National Natural Science Foundation of China (31460682).
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NR 31
TC 6
Z9 6
U1 0
U2 4
PU UNIV AGRICULTURE, FAC VETERINARY SCIENCE
PI FAISALABAD
PA UNIV AGRICULTURE, FAC VETERINARY SCIENCE, FAISALABAD, 00000, PAKISTAN
SN 0253-8318
EI 2074-7764
J9 PAK VET J
JI Pak. Vet. J.
PY 2019
VL 39
IS 4
BP 527
EP 533
DI 10.29261/pakvetj/2019.076
PG 7
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA JV3IY
UT WOS:000502261100010
OA gold
DA 2025-06-11
ER

PT J
AU Kawamoto, R
   Ninomiya, D
   Hasegawa, Y
   Kasai, Y
   Kusunoki, T
   Ohtsuka, N
   Kumagi, T
   Abe, M
AF Kawamoto, Ryuichi
   Ninomiya, Daisuke
   Hasegawa, Yoichi
   Kasai, Yoshihisa
   Kusunoki, Tomo
   Ohtsuka, Nobuyuki
   Kumagi, Teru
   Abe, Masanori
TI Mildly elevated serum total bilirubin levels are negatively associated
   with carotid atherosclerosis among elderly persons with type 2 diabetes
SO CLINICAL AND EXPERIMENTAL HYPERTENSION
LA English
DT Article
DE Atherosclerosis; carotid artery; confounding factor; Serum total
   bilirubin; ultrasonography; type 2 diabetes
ID INTIMA-MEDIA THICKNESS; CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME;
   OXIDATIVE STRESS; RENAL-DISEASE; URIC-ACID; RISK; ARTERY; ANTIOXIDANT;
   MELLITUS
AB Diabetes is strongly associated with several mechanisms of tissue damage such as oxidative stress. Serum bilirubin may have a beneficial role in preventing oxidative changes in cardiovascular disease (CVD). Limited information is available on whether serum bilirubin is an independent confounding factor for carotid atherosclerosis among elderly persons with type 2 diabetes. The study subjects were 169 men aged 79 +/- 8 (mean +/- SD) years and 205 women aged 81 +/- 8 years that were enrolled consecutively from patients in the medical department. Carotid intima-media thickness (IMT) and plaque were derived via B-mode ultrasonography. Multiple linear regression analysis showed that serum total bilirubin (=-0.160) was significantly associated with carotid IMT. Compared to subjects with a serum total bilirubin of tertile-1 (0.13-0.58mg/dL), the multivariate-adjusted odds ratio (95% confidence interval) of carotid IMT 1.0mm including plaque and carotid plaque was 0.46 (0.23-0.93) and 0.32 (0.17-0.60) in the Tertile-3 group (0.87-1.93mg/dL), respectively. Next, data were further stratified by gender, age, smoking status, medication and prevalence of CVD. There were no significant differences in serum total bilirubin levels between selected subgroups. Our data demonstrated a negative association between serum total bilirubin and carotid atherosclerosis among elderly persons with type 2 diabetes.
C1 [Kawamoto, Ryuichi; Ninomiya, Daisuke; Hasegawa, Yoichi; Kumagi, Teru; Abe, Masanori] Ehime Univ, Grad Sch Med, Dept Community Med, Matsuyama, Ehime 790, Japan.
   [Kawamoto, Ryuichi; Ninomiya, Daisuke; Hasegawa, Yoichi; Kasai, Yoshihisa; Kusunoki, Tomo; Ohtsuka, Nobuyuki] Seiyo Municipal Nomura Hosp, Dept Internal Med, Seiyo City, Ehime 7971212, Japan.
C3 Ehime University
RP Kawamoto, R (corresponding author), Seiyo Municipal Nomura Hosp, Dept Internal Med, 9-53 Nomura,Nomura Cho, Seiyo City, Ehime 7971212, Japan.
EM rykawamo@m.ehime-u.ac.jp
RI Kumagi, Teru/AAS-7427-2021
OI Kumagi, Teru/0000-0002-2292-7750
FU Foundation for the Development of the Community
FX The authors declare that they have no competing interests. This study
   was supported, in part, by a grant-in-aid from the Foundation for the
   Development of the Community (2014).
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NR 37
TC 17
Z9 17
U1 0
U2 7
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1064-1963
EI 1525-6006
J9 CLIN EXP HYPERTENS
JI Clin. Exp. Hypertens.
PD JAN 2
PY 2016
VL 38
IS 1
BP 107
EP 112
DI 10.3109/10641963.2015.1060990
PG 6
WC Pharmacology & Pharmacy; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Cardiovascular System & Cardiology
GA DA6NI
UT WOS:000367921300015
PM 26362780
DA 2025-06-11
ER

PT J
AU Ehtisham, J
   Altieri, M
   Salame, E
   Saloux, E
   Ollivier, I
   Hamon, M
AF Ehtisham, Javed
   Altieri, Mario
   Salame, Ephrem
   Saloux, Eric
   Ollivier, Isabelle
   Hamon, Martial
TI Coronary Artery Disease in Orthotopic Liver Transplantation:
   Pretransplant Assessment and Management
SO LIVER TRANSPLANTATION
LA English
DT Review
ID DOBUTAMINE STRESS ECHOCARDIOGRAPHY; CARDIAC OPERATIONS; CARDIOVASCULAR
   RISK; METABOLIC SYNDROME; PREDICTIVE-VALUE; STATIN THERAPY; BYPASS;
   CIRRHOSIS; SURGERY; PRAVASTATIN
AB The prevalence of coronary artery disease in end-stage liver disease is only now being recognized. Liver transplant patients are a high risk subgroup for coronary artery disease, even if asymptomatic. Coronary artery disease is a predictor of poor outcomes; therefore, identification of those at risk must be a key clinical priority. However, risk assessment is particularly difficult as many of the available diagnostic tools have either proven to be unhelpful or remain to be validated. Risk factor profiling has been unable to identify those at risk and commonly underestimates risk. The high negative predictive value of Dobutamine stress echo, when target heart rates are achieved, allows it to be used to identify a low risk group. For all other patients, proceeding to invasive coronary angiography is often necessary, and the risks of the procedure can be reduced by a transradial approach. Pharmacological reduction of the consequences of coronary artery disease can be limited by the underlying liver disease. Revascularization pre-transplantation is recommended in international guidelines but has demonstrated little evidence of benefit. Surgical revascularization carries an increased risk in these patients and is commonly performed pre-transplantation, although combined liver and cardiac surgery has been described. Percutaneous coronary intervention is increasingly used with patients requiring anti-platelet medication for up to one year after intervention. We present a review of all these issues and the evidence for assessing and managing these high-risk patients. Liver Transpl 16:550-557, 2010. (C) 2010 AASLD.
C1 [Ehtisham, Javed; Saloux, Eric; Hamon, Martial] Univ Hosp Caen, Dept Cardiol, Normandy, France.
   [Altieri, Mario; Salame, Ephrem] Univ Hosp Caen, Dept Surg, Normandy, France.
   [Ollivier, Isabelle] Univ Hosp Caen, Dept Hepatogastroenterol, Normandy, France.
   [Hamon, Martial] Natl Inst Hlth & Med Res, Unit 744, Lille, France.
C3 CHU de Caen NORMANDIE; CHU de Caen NORMANDIE; CHU de Caen NORMANDIE;
   Institut National de la Sante et de la Recherche Medicale (Inserm)
RP Hamon, M (corresponding author), CHU Caen, UF Soins Intensifs Cardiol, Serv Malad Coeur & Vaisseaux, Ave Cote Nacre, F-14033 Caen, Normandy, France.
EM hamon-m@chu-caen.fr
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NR 84
TC 61
Z9 63
U1 0
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1527-6465
EI 1527-6473
J9 LIVER TRANSPLANT
JI Liver Transplant.
PD MAY
PY 2010
VL 16
IS 5
BP 550
EP 557
DI 10.1002/lt.22035
PG 8
WC Gastroenterology & Hepatology; Surgery; Transplantation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery; Transplantation
GA 594HH
UT WOS:000277526500003
PM 20440764
DA 2025-06-11
ER

PT J
AU Tarnopolsky, M
   Zimmer, A
   Paikin, J
   Safdar, A
   Aboud, A
   Pearce, E
   Roy, B
   Doherty, T
AF Tarnopolsky, Mark
   Zimmer, Andrew
   Paikin, Jeremy
   Safdar, Adeel
   Aboud, Alissa
   Pearce, Erin
   Roy, Brian
   Doherty, Timothy
TI Creatine Monohydrate and Conjugated Linoleic Acid Improve Strength and
   Body Composition Following Resistance Exercise in Older Adults
SO PLOS ONE
LA English
DT Article
ID HUMAN SKELETAL-MUSCLE; C-REACTIVE PROTEIN; FAT MASS; SATELLITE CELL;
   ELDERLY-MEN; LIPID-PEROXIDATION; ORAL CREATINE; INSULIN SENSITIVITY;
   METABOLIC SYNDROME; OXIDATIVE STRESS
AB Aging is associated with lower muscle mass and an increase in body fat. We examined whether creatine monohydrate (CrM) and conjugated linoleic acid (CLA) could enhance strength gains and improve body composition (i.e., increase fat-free mass (FFM); decrease body fat) following resistance exercise training in older adults (>65 y). Men (N = 19) and women (N = 20) completed six months of resistance exercise training with CrM (5g/d)+CLA (6g/d) or placebo with randomized, double blind, allocation. Outcomes included: strength and muscular endurance, functional tasks, body composition (DEXA scan), blood tests (lipids, liver function, CK, glucose, systemic inflammation markers (IL-6, C-reactive protein)), urinary markers of compliance (creatine/creatinine), oxidative stress (8-OH-2dG, 8-isoP) and bone resorption (N-telopeptides). Exercise training improved all measurements of functional capacity (P < 0.05) and strength (P < 0.001), with greater improvement for the CrM+CLA group in most measurements of muscular endurance, isokinetic knee extension strength, FFM, and lower fat mass (P < 0.05). Plasma creatinine (P < 0.05), but not creatinine clearance, increased for CrM+CLA, with no changes in serum CK activity or liver function tests. Together, this data confirms that supervised resistance exercise training is safe and effective for increasing strength in older adults and that a combination of CrM and CLA can enhance some of the beneficial effects of training over a six-month period.
C1 [Tarnopolsky, Mark; Zimmer, Andrew; Paikin, Jeremy; Safdar, Adeel; Aboud, Alissa; Pearce, Erin] McMaster Univ, Dept Pediat & Med, Hamilton, ON, Canada.
   [Roy, Brian] Brock Univ, Dept Phys Educ & Kinesiol, St Catharines, ON L2S 3A1, Canada.
   [Doherty, Timothy] Univ Western Ontario, Dept Clin Neurol Sci, London, ON, Canada.
   [Doherty, Timothy] Univ Western Ontario, Dept Phys Med & Rehabil, London, ON, Canada.
C3 McMaster University; Brock University; Western University (University of
   Western Ontario); Western University (University of Western Ontario)
RP Tarnopolsky, M (corresponding author), McMaster Univ, Dept Pediat & Med, Hamilton, ON, Canada.
EM tarnopol@mcmaster.ca
RI Roy, Brian/V-6612-2019; Doherty, Timothy/H-3576-2015
OI Hatcher, Erin/0000-0002-3638-4742; Safdar, Adeel/0000-0003-2469-0467;
   Roy, Brian/0000-0003-4638-5586
FU Canadian Institute of Health Research
FX This study was funded entirely by the Canadian Institute of Health
   Research.
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NR 79
TC 116
Z9 130
U1 0
U2 19
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD OCT 3
PY 2007
VL 2
IS 10
AR e991
DI 10.1371/journal.pone.0000991
PG 11
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA V10HU
UT WOS:000207455900027
PM 17912368
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Abedi, S
   Vessal, M
   Asadian, F
   Takhshid, MA
AF Abedi, Sara
   Vessal, Mahmood
   Asadian, Fatemeh
   Takhshid, Mohammad Ali
TI Association of serum kynurenine/tryptophan ratio with poor glycemic
   control in patients with type2 diabetes
SO JOURNAL OF DIABETES AND METABOLIC DISORDERS
LA English
DT Article
DE Type 2 diabetes mellitus; Insulin resistance; Indoleamine 2; 3
   dioxygenase; Oxidative stress
ID INSULIN-RESISTANCE; INDOLEAMINE 2,3-DIOXYGENASE; KYNURENINE; OBESITY;
   INFLAMMATION; EXPRESSION; MELLITUS; PEOPLE
AB Purpose The role of indoleamine 2,3-dioxygenase (IDO) has been shown in insulin resistance and metabolic syndrome. The present study aimed to measure serum IDO activity in patients with type 2 diabetes (T2DM) and to determine its association with glycemic control, oxidative stress, and insulin resistance. Methods Seventy-four patients with T2DM and 74 healthy subjects were selected to participate in this study. Fasting serum biochemical parameters including fasting blood sugar (FBS), HbA1c, insulin, uric acid, albumin, tryptophan, kynurenine, and total antioxidant capacity (TAC) were measured. HOMA-IR, QUICKI, and HOMA-B were calculated using serum FBS and insulin values. IDO activity was estimated using kynurenine/tryptophan ratio (KTR). Data were analyzed using SPSS software (Version 15) and p < 0.05 was considered as a significant difference. Results The findings showed higher levels of FBS, HbA1c, HOMA-IR, and KTR in the patients compared to the controls. TAC and HOMA-B were significantly lowered in the T2DM patients compared to controls. KTR was significantly correlated with the level of HbA1c, and T2DM patients with poor glycemic control (HbA1c <= 8) had significantly higher level of KTR. HOMA-B was significantly correlated with serum tryptophan and inversely correlated with HbA1c. Conclusion Serum KTR is increased in T2DM patients with poor glycemic control. Potential clinical implications and possible pathogenic roles of IDO in T2DM development should be further elucidated.
C1 [Abedi, Sara; Vessal, Mahmood] Islamic Azad Univ, Dept Mol Biol Biochem, Shiraz Branch, Shiraz, Iran.
   [Asadian, Fatemeh; Takhshid, Mohammad Ali] Shiraz Univ Med Sci, Sch Paramed Sci, Lab Sci Dept, Shiraz, Iran.
   [Takhshid, Mohammad Ali] Shiraz Univ Med Sci, Diagnost Lab Sci & Technol Res Ctr, Sch Paramed Sci, Meshkinfam St, Shiraz, Iran.
C3 Islamic Azad University; Shiraz University of Medical Science; Shiraz
   University of Medical Science
RP Takhshid, MA (corresponding author), Shiraz Univ Med Sci, Sch Paramed Sci, Lab Sci Dept, Shiraz, Iran.; Takhshid, MA (corresponding author), Shiraz Univ Med Sci, Diagnost Lab Sci & Technol Res Ctr, Sch Paramed Sci, Meshkinfam St, Shiraz, Iran.
EM saraabedi65@yahoo.com; Mahmoodv@yahoo.com; Asadian@sums.ac.ir;
   takhshidma@sums.ac.ir
RI takhshid, mohammad/P-1190-2017; Asadian, Fatemeh/W-3257-2018
OI Asadian, Fatemeh/0000-0002-5421-7761; Takhshid, Mohammad
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NR 46
TC 15
Z9 15
U1 0
U2 6
PU SPRINGER INT PUBL AG
PI CHAM
PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND
EI 2251-6581
J9 J DIABETES METAB DIS
JI J. Diabetes Metab. Disord.
PD DEC
PY 2021
VL 20
IS 2
BP 1521
EP 1527
DI 10.1007/s40200-021-00895-z
EA SEP 2021
PG 7
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA XE9GG
UT WOS:000695944000001
PM 34900804
OA Green Published
DA 2025-06-11
ER

PT J
AU Youssef, DA
   El-Fayoumi, HM
   Mahmoud, MF
AF Youssef, Dareen A.
   El-Fayoumi, Hassan M.
   Mahmoud, Mona F.
TI Beta-caryophyllene protects against diet-induced dyslipidemia and
   vascular inflammation in rats: Involvement of CB2 and PPAR-γ receptors
SO CHEMICO-BIOLOGICAL INTERACTIONS
LA English
DT Article
DE Beta-caryophyllene; Insulin resistance; Cannabinoid receptor 2;
   PPAR-gamma; Vascular inflammation; High fat/fructose diet
ID HIGH-FAT DIET; OXIDATIVE STRESS; INSULIN-RESISTANCE; NATURAL
   SESQUITERPENE; CANNABINOID RECEPTORS; TRANS-CARYOPHYLLENE; METABOLIC
   SYNDROME; ATHEROGENIC INDEX; TNF-ALPHA; PIOGLITAZONE
AB Beta-caryophyllene (BCP) is a phytocannabinoid possessing selective agonistic activity to cannabinoid type-2 receptors (CB2R) and peroxisome proliferator-activated receptors-alpha (PPAR-alpha). However, few studies reported the contribution of PPAR-gamma receptors in BCP effects. The aim of this study was to investigate the BCP effects on diet-induced dyslipidemia and vascular inflammation as well as the involvement of CB2R and PPAR-gamma receptors. Wistar rats were fed a high-fat diet and administered 10% fructose for 12 weeks. Treatment with pioglitazone, BCP, BCP + CB2R antagonist, AM630, or BCP + PPAR-gamma antagonist, BADGE was started from the 9th week and continued till the 12th week. BCP significantly ameliorated all diet-induced alterations in a CB2R-dependant manner as it improved glycemic parameters, dyslipidemia, and vascular oxidative stress and inflammation. It also downregulated proatherogenic adhesion molecule (VCAM-1) and restored vascular eNOS/iNOS expression balance. PPAR-gamma was involved in BCP-evoked suppression of vascular inflammation, VCAM-1 and restoration of normal vascular eNOS/iNOS balance thus normal NO level. Furthermore, part of BCP hypolipidemic effects (lowering total cholesterol, LDL, VLDL) involved both CB2R and PPAR-gamma receptors. BCP treatment was superior to pioglitazone in anti-inflammatory and anti-atherosclerotic measures. BCP may represent a more potent alternate to pioglitazone avoiding its side effects in the treatment of insulin resistance and vascular inflammation.
C1 [Youssef, Dareen A.; El-Fayoumi, Hassan M.; Mahmoud, Mona F.] Zagazig Univ, Dept Pharmacol & Toxicol, Fac Pharm, Zagazig, Egypt.
   [El-Fayoumi, Hassan M.] Sinai Univ Qantara, Fac Pharm, Pharmacol & Toxicol, Ismailia, Egypt.
C3 Egyptian Knowledge Bank (EKB); Zagazig University; Egyptian Knowledge
   Bank (EKB); Sinai University
RP Mahmoud, MF (corresponding author), Zagazig Univ, Dept Pharmacol & Toxicol, Fac Pharm, Zagazig 44519, Al Sharkia, Egypt.
EM mona_pharmacology@yahoo.com
RI Youssef, Dareen/ABH-3574-2020; Mahmoud, Mona/Q-8851-2019
OI Mahmoud, Mona/0000-0002-5312-2066; Youssef, Dareen/0000-0002-6672-3258
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NR 65
TC 63
Z9 68
U1 0
U2 13
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0009-2797
EI 1872-7786
J9 CHEM-BIOL INTERACT
JI Chem.-Biol. Interact.
PD JAN 5
PY 2019
VL 297
BP 16
EP 24
DI 10.1016/j.cbi.2018.10.010
PG 9
WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology
GA HD7FC
UT WOS:000452715400003
PM 30343038
DA 2025-06-11
ER

PT J
AU Kamada, Y
   Matsumoto, H
   Tamura, S
   Fukushima, J
   Kiso, S
   Fukui, K
   Igura, T
   Maeda, N
   Kihara, S
   Funahashi, T
   Matsuzawa, Y
   Shimomura, L
   Hayashi, N
AF Kamada, Yoshihiro
   Matsumoto, Hitoshi
   Tamura, Shinji
   Fukushima, Juichi
   Kiso, Shinichi
   Fukui, Koji
   Igura, Takumi
   Maeda, Norikazu
   Kihara, Shinji
   Funahashi, Tohru
   Matsuzawa, Yuji
   Shimomura, Lichiro
   Hayashi, Norio
TI Hypoadiponectinemia accelerates hepatic tumor formation in a
   nonalcoholic steatohepatitis mouse model
SO JOURNAL OF HEPATOLOGY
LA English
DT Article
DE nonalcoholic steatohepatitis (NASH); hepatocellular carcinoma (HCC);
   adiponectin; reactive oxygen species (ROS); obesity
ID ADIPOSE-SPECIFIC PROTEIN; NECROSIS-FACTOR-ALPHA; METABOLIC SYNDROME;
   LIVER FIBROSIS; HEPATOCELLULAR-CARCINOMA; INSULIN-RESISTANCE;
   CHOLINE-DEFICIENT; CANCER RISK; US ADULTS; ADIPONECTIN
AB Background/Aims: Adipose tissue produces a number of adipocytokines, including adiponectin, leptin, and tumor necrosis factor-alpha. Obesity, which is associated with low plasma adiponectin levels, is an independent risk factor for various liver diseases including nonalcoholic steatohepatitis (NASH). The aim of this study was to examine the effects of adiponectin on the progression of NASH to cirrhosis and tumor formation using adiponectin-knockout (KO) mice.
   Methods: Using a choline-deficient L-amino acid-defined (CDAA) diet-induced mouse NASH model, liver histology and oxidative stress markers were investigated in KO and wild-type (WT) mice.
   Results: Hepatic steatosis was enhanced to a greater extent in KO mice, compared to WT mice after a 1-week CDAA diet. After 24 weeks, 6 out of 14 KO mice developed liver cirrhosis and hepatic tumors, whereas the 15 WT mice showed only simple steatosis. In KO mice, hepatic cytochrome P450 2E1 levels were upregulated, and markers of oxidative stress (thiobarbituric acid reactive substances, 8-hydroxydeoxyguanosine-positive cells) were significantly increased compared with WT mice.
   Conclusions: Our results indicate that lack of adiponectin enhances the progression of hepatic steatosis, fibrosis, and hepatic tumor formation in an animal model of NASH. Hypoadiponectinemia in obesity could be a risk factor for NASH-related hepatic tumor formation. (C) 2007 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
C1 Osaka Univ, Grad Sch Med, Dept Gastroenterol & Hepatol, Osaka 565, Japan.
   Osaka Univ, Grad Sch Med, Dept Metab Med, Osaka 565, Japan.
   Sumimoto Hosp, Kita Ku, Osaka 530, Japan.
C3 The University of Osaka; The University of Osaka; Sumitomo Hospital
RP Tamura, S (corresponding author), Osaka Univ, Grad Sch Med, Dept Gastroenterol & Hepatol, 2-2 K1, Osaka 565, Japan.
EM tamura@gh.med.osaka-u.ac.jp
RI Kihara, Shinji/AAW-2015-2021; Fukui, Koji/I-7067-2019; Maeda,
   Norikazu/LZI-4561-2025; Kamada, Yoshihiro/H-3309-2019
OI Kamada, Yoshihiro/0000-0001-5485-902X
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NR 45
TC 160
Z9 168
U1 0
U2 3
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0168-8278
J9 J HEPATOL
JI J. Hepatol.
PD OCT
PY 2007
VL 47
IS 4
BP 556
EP 564
DI 10.1016/j.jhep.2007.03.020
PG 9
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 218OQ
UT WOS:000250025200019
PM 17459514
DA 2025-06-11
ER

PT J
AU Tan, T
   Song, ZY
   Li, WY
   Wang, RM
   Zhu, ML
   Liang, ZX
   Bai, YLN
   Wang, Q
   Wu, HY
   Hu, XX
   Xing, YM
AF Tan, Tan
   Song, Zhiyuan
   Li, Wenya
   Wang, Runming
   Zhu, Mingli
   Liang, Zuoxiang
   Bai, Yilina
   Wang, Qi
   Wu, Hanyu
   Hu, Xiaoxiang
   Xing, Yiming
TI Modelling porcine NAFLD by deletion of leptin and defining the role of
   AMPK in hepatic fibrosis
SO CELL AND BIOSCIENCE
LA English
DT Article
DE Liver fibrosis; LEPTIN; Pig; NAFLD; AMPK pathway
ID FATTY LIVER-DISEASE; NF-KAPPA-B; EXPRESSION; SUPPRESSORS; MECHANISMS;
   RESISTANCE; STEATOSIS; STRESS; MATRIX
AB BackgroundNon-alcoholic fatty liver disease (NAFLD) is the most prevalent cause of chronic hepatic disease and results in non-alcoholic steatohepatitis (NASH), which progresses to fibrosis and cirrhosis. Although the Leptin deficient rodent models are widely used in study of metabolic syndrome and obesity, they fail to develop liver injuries as in patients.MethodsDue to the high similarity with humans, we generated Leptin-deficient (Leptin-/-) pigs to investigate the mechanisms and clinical trials of obesity and NAFLD caused by Leptin.ResultsThe Leptin-/- pigs showed increased body fat and significant insulin resistance at the age of 12 months. Moreover, Leptin-/- pig developed fatty liver, non-alcoholic steatohepatitis and hepatic fibrosis with age. Absence of Leptin in pig reduced the phosphorylation of JAK2-STAT3 and AMPK. The inactivation of JAK2-STAT3 and AMPK enhanced fatty acid beta-oxidation and leaded to mitochondrial autophagy respectively, and both contributed to increased oxidative stress in liver cells. In contrast with Leptin-/- pig, although Leptin deletion in rat liver inhibited JAK2-STAT3 phosphorylation, the activation of AMPK pathway might prevent liver injury. Therefore, beta-oxidation, mitochondrial autophagy and hepatic fibrosis did not occurred in Leptin-/- rat livers.ConclusionsThe Leptin-deficient pigs presents an ideal model to illustrate the full spectrum of human NAFLD. The activity of AMPK signaling pathway suggests a potential target to develop new strategy for the diagnosis and treatment of NAFLD.
C1 [Tan, Tan; Song, Zhiyuan; Li, Wenya; Wang, Runming; Zhu, Mingli; Liang, Zuoxiang; Bai, Yilina; Wang, Qi; Wu, Hanyu; Hu, Xiaoxiang; Xing, Yiming] China Agr Univ, Coll Biol Sci, State Key Lab Anim Biotech Breeding, Beijing, Peoples R China.
   [Tan, Tan] Minist Agr & Rural Affairs, Dev Ctr Sci & Technol, Beijing, Peoples R China.
C3 China Agricultural University; Ministry of Agriculture & Rural Affairs
RP Xing, YM (corresponding author), China Agr Univ, Coll Biol Sci, State Key Lab Anim Biotech Breeding, Beijing, Peoples R China.
EM ymxing@cau.edu.cn
RI Wang, Runming/AAC-7465-2019; Song, Zhiyuan/HSB-6014-2023; Xing,
   Yiming/HTL-8845-2023
FU We are grateful for the gift of
   Leptin-/- pigs by Dr. Ning
   Li and Leptin-/- rats by
   Dr. Sen Wu. We would like to acknowledge the helps of Dr. Changgong Li
   for technic
FX We are grateful for the gift of
   <ITALIC>Leptin</ITALIC><SUP><ITALIC>-/-</ITALIC></SUP> pigs by Dr. Ning
   Li and <ITALIC>Leptin</ITALIC><SUP><ITALIC>-/-</ITALIC></SUP> rats by
   Dr. Sen Wu. We would like to acknowledge the helps of Dr. Changgong Li
   for technical supporting and Dr. Lennart Hammarstrom for manuscript
   writing.
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NR 37
TC 4
Z9 4
U1 1
U2 12
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 2045-3701
J9 CELL BIOSCI
JI Cell Biosci.
PD SEP 13
PY 2023
VL 13
IS 1
AR 169
DI 10.1186/s13578-023-01124-1
PG 17
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA W9EM3
UT WOS:001094587500002
PM 37705071
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Inaba, T
   Ohnishi-Kameyama, M
   Liu, Y
   Tanaka, Y
   Kobori, M
   Tamaki, S
   Ito, T
   Higa, K
   Shimazaki, J
   Tsubota, K
AF Inaba, Takaaki
   Ohnishi-Kameyama, Mayumi
   Liu, Ying
   Tanaka, Yasuhisa
   Kobori, Masuko
   Tamaki, Shusaku
   Ito, Tomotaka
   Higa, Kazunari
   Shimazaki, Jun
   Tsubota, Kazuo
TI Quercetin improves lacrimal gland function through its anti-oxidant
   actions: Evidence from animal studies, and a pilot study in healthy
   human volunteers
SO FRONTIERS IN NUTRITION
LA English
DT Article
DE quercetin; dry eye; tear secretion; lacrimal gland; anti-oxidant
ID DRY EYE; OXIDATIVE STRESS; DIETARY SUPPLEMENTATION; OCULAR INFLAMMATION;
   METABOLIC SYNDROME; BLOOD-PRESSURE; FISH-OIL; RESVERATROL; DYSFUNCTION;
   PREVENTION
AB Anti-oxidant properties of polyphenols have been gaining medical attention as a preventive factor against aging and/or lifestyle diseases. In this study, we examined the anti-oxidant activity of quercetin improved tear function through its effects on the lacrimal gland in mice and humans. Six week-old diabetic mice, a model for decreased tear production, were fed for 12 weeks ad libitum with an experimental diet containing 0.5% quercetin. As a result, the tear volume was significantly improved compared to the control, despite no changes in body weight, food intake, lacrimal gland morphology or biochemical serum parameters. Moreover, significantly higher SOD-1 and SOD-2 protein levels were detected in the lacrimal glands of quercetin-treated mice by western blot. In addition, quercetin treatment of mouse corneal cell lines exposed to oxidative stress resulted in dose-dependent inhibition of ROS production and enhanced cell survival. Finally, we examined quercetin pharmacokinetics, specifically its presence in serum and tears subsequent to onion consumption in healthy volunteers, and found that the distribution of quercetin and its metabolite shifted from serum to tear following onion intake. An improvement in tear film stability also resulted following the intake by these healthy volunteers of a new, quercetin-rich onion cultivar ("Quergold") in powder form. These results suggested that quercetin improved tear function through its effects on the lacrimal gland in mice and humans.
C1 [Inaba, Takaaki; Liu, Ying; Tanaka, Yasuhisa; Tamaki, Shusaku; Ito, Tomotaka; Tsubota, Kazuo] Keio Univ Sch Med, Dept Ophthalmol, Tokyo, Japan.
   [Inaba, Takaaki; Higa, Kazunari; Shimazaki, Jun] Tokyo Dent Coll Ichikawa Gen Hosp, Cornea Ctr, Dept Ophthalmol, Ichikawa, Japan.
   [Ohnishi-Kameyama, Mayumi; Kobori, Masuko] Natl Agr & Food Res Org NARO, Food Res Inst, Tsukuba, Japan.
   [Tsubota, Kazuo] Tsubota Lab Inc, Tokyo, Japan.
C3 Keio University; Tokyo Dental College; National Agriculture & Food
   Research Organization - Japan
RP Tsubota, K (corresponding author), Keio Univ Sch Med, Dept Ophthalmol, Tokyo, Japan.; Tsubota, K (corresponding author), Tsubota Lab Inc, Tokyo, Japan.
EM tsubota@tsubota-lab.com
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NR 37
TC 13
Z9 13
U1 5
U2 20
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD OCT 6
PY 2022
VL 9
AR 974530
DI 10.3389/fnut.2022.974530
PG 13
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 5U2ZR
UT WOS:000876422000001
PM 36313100
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Paudel, YN
   Ali, MR
   Shah, S
   Adil, M
   Akhtar, MS
   Wadhwa, R
   Bawa, S
   Sharma, M
AF Paudel, Yam Nath
   Ali, Md. Rahmat
   Shah, Sadia
   Adil, Mohd
   Akhtar, Md. Sayeed
   Wadhwa, Ravisha
   Bawa, Sandhya
   Sharma, Manju
TI 2-[(4-Chlorobenzyl) amino]-4-methyl-1,3-thiazole-5-carboxylic acid
   exhibits antidiabetic potential and raises insulin sensitivity via
   amelioration of oxidative enzymes and inflammatory cytokines in
   streptozotocin induced diabetic rats
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Article
DE NIDDM; Insulin resistance; Hyperinsulinemia; Oxidative stress;
   Inflammatory cytokines; Streptozotocin
ID BETA-CELL DYSFUNCTION; TNF-ALPHA; CHROMIUM PICOLINATE;
   WITHANIA-SOMNIFERA; METABOLIC SYNDROME; RESISTANCE; STRESS;
   HYPERGLYCEMIA; THIAZOLE; MELLITUS
AB Thiazole derivatives are potential candidates for drug development. They can be efficiently synthesized and are extremely active against several diseases, including diabetes. In our present study, we investigated the anti-diabetic, anti-oxidant and anti-inflammatory properties of 2-[(4-Chlorobenzyl) amino]-4-methyl-1,3-thiazole-5-carboxylic acid (BAC) a new thiazole derivative, in a streptozotocin (STZ) induced neonatal model of non-insulin dependent diabetes mellitus (NIDDM) rats. Diabetes was induced by injecting STZ (100 mg/kg) intraperitoneally to two days old pups. BAC administration for 3 weeks significantly decreased blood glucose and raised insulin level and improves insulin sensitivity (K-ITT) level. Additionally, BAC also suppressed several inflammatory cytokines generation as evidenced by decreased levels of serum tumor necrosis factor-a and interleukin-6. In addition, BAC also protects against hyperlipidemia and liver injury. Furthermore, BAC significantly restored pancreatic lipid peroxidation, catalase, superoxide dismutase, and reduced glutathione content. Histological studies of pancreatic tissues showed normal architecture after BAC administration to diabetic rats. Altogether, our results suggest that BAC successfully reduces the blood glucose level and possesses anti-oxidant as well as anti-inflammatory activity. This leads to decreased histological damage in diabetic pancreatic tissues suggesting the possibility of future diabetes treatments. (C) 2017 Elsevier Masson SAS. All rights reserved.
C1 [Paudel, Yam Nath; Shah, Sadia; Adil, Mohd; Akhtar, Md. Sayeed; Wadhwa, Ravisha; Sharma, Manju] Jamia Hamdard, Fac Pharm, Dept Pharmacol, New Delhi 110062, India.
   [Ali, Md. Rahmat; Bawa, Sandhya] Jamia Hamdard, Fac Pharm, Dept Pharmaceut Chem, New Delhi 110062, India.
   [Akhtar, Md. Sayeed] Sharda Univ, Sch Allied Hlth Sci, Greater Noida, Uttar Pradesh, India.
C3 Jamia Hamdard University; Jamia Hamdard University; Sharda University
RP Sharma, M (corresponding author), Jamia Hamdard, Fac Pharm, Dept Pharmacol, New Delhi 110062, India.
EM msharma@jamiahamdard.ac.in
RI Sharma, Manju/E-3735-2016; akhtar, sayeed/AAY-3459-2020; SHAH,
   SADIA/JEF-4998-2023; Adil, Mohammad/B-9401-2017; Paudel, Yam/L-2908-2019
OI Sharma, Manju/0000-0003-4013-6626; Akhtar, Mohd/0000-0002-3333-2672
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NR 53
TC 22
Z9 22
U1 0
U2 3
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD MAY
PY 2017
VL 89
BP 651
EP 659
DI 10.1016/j.biopha.2017.02.043
PG 9
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA EW4JQ
UT WOS:000402468200075
PM 28262618
DA 2025-06-11
ER

PT J
AU Guizoni, DM
   Vettorazzi, JF
   Carneiro, EM
   Davel, AP
AF Guizoni, Daniele M.
   Vettorazzi, Jean F.
   Carneiro, Everardo M.
   Davel, Ana Paula
TI Modulation of endothelium-derived nitric oxide production and activity
   by taurine and taurine-conjugated bile acids
SO NITRIC OXIDE-BIOLOGY AND CHEMISTRY
LA English
DT Article
DE Nitric oxide; Taurine; Taurine-conjugated bile acids; Endothelium;
   Vasodilation
ID ENDOPLASMIC-RETICULUM STRESS; FARNESOID-X RECEPTOR; TAUROURSODEOXYCHOLIC
   ACID; ASYMMETRIC DIMETHYLARGININE; HYDROGEN-SULFIDE; OXIDATIVE STRESS;
   HEART-DISEASE; DYSFUNCTION; RAT; EXPRESSION
AB Taurine is a semiessential amino acid found at high concentrations in mammalian plasma and cells, where it regulates cellular functions such as ion flux, controls cell volume and serves as a substrate for conjugated bile acids (BM). Exogenous administration of both taurine and taurine-conjugated BAs have also been implicated in the modulation of cardiovascular functions. This brief review summarizes the role of taurine and taurine-conjugated BAs in vascular relaxation through the modulation of endothelium-derived nitric oxide (NO). The effects of taurine on vascular health are controversial. However, in the presence of cardiometabolic risk factors, it has been proposed that taurine can increase vascular NO levels by increasing eNOS expression, eNOS phosphorylation on Ser1177, NO bioavailability, the level of antioxidative defense, and the L-arginine/NOS inhibitor asymmetric dimethylarginine (ADMA) ratio. The taurine-conjugated BA-mediated activation of Farnesoid X receptor (FXR), G protein-coupled BA receptor (TGR5) and/or muscarinic 3 receptor (M3) was also reported to increase vascular NO production. FXR activation increases eNOS expression and may reduce ADMA formation, while TGR5 increases mobilization of Ca2+ and phosphorylation of eNOS and Akt in endothelial cells. Furthermore, taurine and taurine-conjugated BAs might regulate NO synthesis and activity by enhancing H2S generation. Several studies have demonstrated the beneficial effects of both taurine and taurine-conjugated BAs in reversing the endothelial dysfunction associated with diabetes, atherosclerosis, hypertension, obesity, malnutrition, and smoking. In addition, taurine-conjugated BAs have emerged as a potential treatment for portal hypertension. Despite these favorable findings, there is a need to further explore the mechanisms and signaling pathways underlying the endothelial effects of taurine and taurine-conjugated BAs. Here, we summarize the main findings regarding the effects of taurine and taurine-conjugated BAs on the endothelial dysfunction associated with altered NO metabolism in cardiovascular diseases.
C1 [Guizoni, Daniele M.; Carneiro, Everardo M.; Davel, Ana Paula] Univ Estadual Campinas, Inst Biol, Dept Struct & Funct Biol, UNICAMP, Campinas, SP, Brazil.
   [Vettorazzi, Jean F.; Carneiro, Everardo M.] Univ Estadual Campinas, Sao Paulo Res Fdn FAPESP, Obes & Comorbid Res Ctr, Inst Biol,UNICAMP,Dept Struct & Funct Biol, Campinas, SP, Brazil.
C3 Universidade Estadual de Campinas; Universidade de Sao Paulo;
   Universidade Estadual de Campinas; Fundacao de Amparo a Pesquisa do
   Estado de Sao Paulo (FAPESP); Universidade de Sao Paulo
RP Davel, AP (corresponding author), Univ Estadual Campinas, Inst Biol, Dept Struct & Funct Biol, Bertrand Russel Ave, Campinas, SP, Brazil.
EM anadavel@unicamp.br
RI Carneiro, Everardo/D-4758-2012; Mendes Guizoni, Daniele/R-6974-2018;
   Davel, Ana/L-8801-2013
OI Mendes Guizoni, Daniele/0000-0001-7317-6371; VETTORAZZI,
   JEAN/0000-0002-6411-2947; Davel, Ana/0000-0002-9862-4262
FU Sao Paulo Research Foundation - FAPESP - Sao Paulo - Brazil
   [2013/07607-8, 2014/01717-9, 2016/14461-8]; Coordenacao de
   Aperfeicoamento de Pessoal de Nivel Superior Brazil (CAPES); Formas
   [2014-01717] Funding Source: Formas; Fundacao de Amparo a Pesquisa do
   Estado de Sao Paulo (FAPESP) [13/07607-8, 14/01717-9, 16/14461-8]
   Funding Source: FAPESP
FX This work was supported by the Sao Paulo Research Foundation - FAPESP -
   Sao Paulo - Brazil [grant numbers 2013/07607-8, 2014/01717-9 and
   2016/14461-8]. This study was also financed in part by the Coordenacao
   de Aperfeicoamento de Pessoal de Nivel Superior Brazil (CAPES). The
   authors declare no conflicts of interest.
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NR 88
TC 49
Z9 57
U1 3
U2 25
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 1089-8603
EI 1089-8611
J9 NITRIC OXIDE-BIOL CH
JI Nitric Oxide-Biol. Chem.
PD JAN 1
PY 2020
VL 94
BP 48
EP 53
DI 10.1016/j.niox.2019.10.008
PG 6
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA KE0YU
UT WOS:000508287900006
PM 31669041
DA 2025-06-11
ER

PT J
AU Akseer, N
   Mehta, S
   Wigle, J
   Chera, R
   Brickman, ZJ
   Al-Gashm, S
   Sorichetti, B
   Vandermorris, A
   Hipgrave, DB
   Schwalbe, N
   Bhutta, ZA
AF Akseer, N.
   Mehta, S.
   Wigle, J.
   Chera, R.
   Brickman, Z. J.
   Al-Gashm, S.
   Sorichetti, B.
   Vandermorris, A.
   Hipgrave, D. B.
   Schwalbe, N.
   Bhutta, Z. A.
TI Non-communicable diseases among adolescents: current status,
   determinants, interventions and policies
SO BMC PUBLIC HEALTH
LA English
DT Article
DE Adolescents; Non-communicable diseases; Determinants; Policies; Risk
   factors
ID SOCIAL-DEVELOPMENT INTERVENTION; EARLY-CHILDHOOD INTERVENTION;
   MIDDLE-INCOME COUNTRIES; CASH TRANSFER PROGRAM; YOUNG-PEOPLE; FOLLOW-UP;
   HEALTH-SERVICES; SEXUAL-BEHAVIOR; YOUTH VIOLENCE; SUBSTANCE USE
AB BackgroundAddressing non-communicable disease (NCDs) is a global priority in the Sustainable Development Goals, especially for adolescents. However, existing literature on NCD burden, risk factors and determinants, and effective interventions and policies for targeting these diseases in adolescents, is limited. This study develops an evidence-based conceptual framework, and highlights pathways between risk factors and interventions to NCD development during adolescence (ages 10-19years) and continuing into adulthood. Additionally, the epidemiologic profile of key NCD risk factors and outcomes among adolescents and preventative NCD policies/laws/legislations are examined, and a multivariable analysis is conducted to explore the determinants of NCDs among adolescents and adults.MethodsWe reviewed literature to develop an adolescent-specific conceptual framework for NCDs. Global data repositories were searched from Jan-July 2018 for data on NCD-related risk factors, outcomes, and policy data for 194 countries from 1990 to 2016. Disability-Adjusted Life Years were used to assess disease burden. A hierarchical modeling approach and ordinary least squares regression was used to explore the basic and underlying causes of NCD burden.ResultsMental health disorders are the most common NCDs found in adolescents. Adverse behaviours and lifestyle factors, specifically smoking, alcohol and drug use, poor diet and metabolic syndrome, are key risk factors for NCD development in adolescence. Across countries, laws and policies for preventing NCD-related risk factors exist, however those targeting contraceptive use, drug harm reduction, mental health and nutrition are generally limited. Many effective interventions for NCD prevention exist but must be implemented at scale through multisectoral action utilizing diverse delivery mechanisms. Multivariable analyses showed that structural/macro, community and household factors have significant associations with NCD burden among adolescents and adults.ConclusionsMulti-sectoral efforts are needed to target NCD risk factors among adolescents to mitigate disease burden and adverse outcomes in adulthood. Findings could guide policy and programming to reduce NCD burden in the sustainable development era.
C1 [Akseer, N.; Mehta, S.; Wigle, J.; Chera, R.; Brickman, Z. J.; Al-Gashm, S.; Sorichetti, B.; Vandermorris, A.; Bhutta, Z. A.] Hosp Sick Children, Ctr Global Child Hlth, Toronto, ON M5G 0A4, Canada.
   [Akseer, N.; Wigle, J.; Sorichetti, B.; Bhutta, Z. A.] Univ Toronto, Dalla Lana Sch Publ Hlth, Toronto, ON, Canada.
   [Vandermorris, A.] Hosp Sick Children, Div Adolescent Med, Toronto, ON, Canada.
   [Hipgrave, D. B.] UNICEF, New York, NY USA.
   [Schwalbe, N.] Spark Consulting, New York, NY USA.
   [Bhutta, Z. A.] Aga Khan Univ, Ctr Excellence Women & Child Hlth, Karachi, Pakistan.
C3 University of Toronto; Hospital for Sick Children (SickKids); University
   of Toronto; University of Toronto; Hospital for Sick Children
   (SickKids); UNICEF; Aga Khan University
RP Akseer, N (corresponding author), Hosp Sick Children, Ctr Global Child Hlth, Toronto, ON M5G 0A4, Canada.; Akseer, N (corresponding author), Univ Toronto, Dalla Lana Sch Publ Hlth, Toronto, ON, Canada.
EM nadia.akseer@gmail.com
RI Bhutta, Zulfiqar/ADZ-0156-2022; Bhutta, Zulfiqar/L-7822-2015
OI Bhutta, Zulfiqar/0000-0003-0637-599X; Wasif,
   Muhammad/0009-0004-1374-302X; Wigle, Jannah/0000-0001-9826-0625;
   Hipgrave, David B/0000-0002-4880-0029
FU UNICEF; Centre for Global Child Health at the Hospital for Sick Children
FX This study was funded by UNICEF and the Centre for Global Child Health
   at the Hospital for Sick Children. The funder commissioned the review,
   but had no role in the research process, methods or inferences from the
   analyses.
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NR 120
TC 83
Z9 86
U1 0
U2 21
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2458
J9 BMC PUBLIC HEALTH
JI BMC Public Health
PD DEC 14
PY 2020
VL 20
IS 1
AR 1908
DI 10.1186/s12889-020-09988-5
PG 20
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA PH0VX
UT WOS:000600142700004
PM 33317507
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Ciftel, S
   Klisic, A
   Ciftel, E
   Mercantepe, T
   Yilmaz, A
   Ciftel, S
   Pinarbas, E
   Toraman, MN
   Mercantepe, F
AF Ciftel, Serpil
   Klisic, Aleksandra
   Ciftel, Enver
   Mercantepe, Tolga
   Yilmaz, Adnan
   Ciftel, Sedat
   Pinarbas, Esra
   Toraman, Merve Nur
   Mercantepe, Filiz
TI Investigating the Hepatic Response to Orlistat and White Tea in Rats on
   a High-Fat Diet
SO LIFE-BASEL
LA English
DT Article
DE hepatosteatosis; high-fat diet; liver; Nf-kB/p65; rat; white tea
ID LIVER-DISEASE; OXIDATIVE STRESS; GREEN TEA; EPIGALLOCATECHIN-3-GALLATE;
   EXTRACT; MODEL
AB High-fat diets have detrimental health impacts that increase the likelihood of developing obesity and metabolic syndrome. This study aimed to examine the potential antioxidant and anti-inflammatory effects of orlistat and white tea in rats fed a high-fat diet. Thirty-two rats were randomized into four groups: control (standard diet), HFD (high-fat diet), HFD+Orlistat (high-fat diet+orlistat), and HFD+WT (high-fat diet+white tea extract). A significant increase in malondialdehyde (MDA) levels and a decrease in total thiol (TT) levels were detected in the HFD group (p < 0.001). On the other hand, a decrease in the MDA level (p < 0.001) and an increase in the TT level were observed in the orlistat and white tea groups compared with those in the HFD group (p < 0.001). Histopathological examinations revealed that, compared with the HFD alone, orlistat and white tea reduced fat accumulation, prevented degenerative changes in hepatocytes, and decreased the histopathological damage score (p = 0.001). Immunohistochemical examinations of nuclear factor-kappa B (NF-kB/p65) revealed that compared with the HFD, orlistat and white tea reduced immunopositivity (p = 0.001). White tea decreases lipid peroxidation and oxidative stress. Both white tea and orlistat decreased fat formation and inflammation in the liver and regulated inflammation by reducing Nf-kB positivity. Nevertheless, further research is needed to assess their impact on human subjects.
C1 [Ciftel, Serpil] Erzurum Training & Res Hosp, Dept Endocrinol & Metab, TR-25100 Erzurum, Turkiye.
   [Klisic, Aleksandra] Univ Montenegro, Fac Med, Podgorica 81000, Montenegro.
   [Klisic, Aleksandra] Primary Hlth Care Ctr, Ctr Lab Diagnost, Podgorica 81000, Montenegro.
   [Ciftel, Enver] Sivas Numune Hosp, Dept Endocrinol & Metab, TR-58060 Sivas, Turkiye.
   [Mercantepe, Tolga] Recep Tayyip Erdogan Univ, Fac Med, Dept Histol & Embryol, TR-53100 Rize, Turkiye.
   [Yilmaz, Adnan; Pinarbas, Esra] Recep Tayyip Erdogan Univ, Fac Med, Dept Biochem, TR-53100 Rize, Turkiye.
   [Ciftel, Sedat] Erzurum Training & Res Hosp, Dept Gastroenterol & Hepatol, TR-25100 Erzurum, Turkiye.
   [Toraman, Merve Nur] Recep Tayyip Erdogan Univ, Fac Med, Dept Nutr & Dietary, TR-53100 Rize, Turkiye.
   [Mercantepe, Filiz] Recep Tayyip Erdogan Univ, Fac Med, Dept Endocrinol & Metab, TR-53100 Rize, Turkiye.
C3 Erzurum Bolge Training & Research Hospital; University of Montenegro;
   Sivas Numune Hospital; Recep Tayyip Erdogan University; Recep Tayyip
   Erdogan University; Erzurum Bolge Training & Research Hospital; Recep
   Tayyip Erdogan University; Recep Tayyip Erdogan University
RP Mercantepe, T (corresponding author), Recep Tayyip Erdogan Univ, Fac Med, Dept Histol & Embryol, TR-53100 Rize, Turkiye.; Mercantepe, F (corresponding author), Recep Tayyip Erdogan Univ, Fac Med, Dept Endocrinol & Metab, TR-53100 Rize, Turkiye.
EM serpil.ciftel@saglik.gov.tr; aleksandranklisic@gmail.com;
   enver.ciftel@saglik.gov.tr; tolga.mercantepe@erdogan.edu.tr;
   adnan.yilmaz@erdogan.edu.tr; sedat.ciftel@saglik.gov.tr;
   esra.pinarbas@erdogan.edu.tr; mervenur.toraman@saglik.gov.tr;
   filiz.mercantepe@saglik.gov.tr
RI Ciftel, serpil/HGC-9673-2022; ÇİFTEL, SEDAT/IZP-6896-2023; Mercantepe,
   Tolga/O-1073-2013; Klisic, Aleksandra/ABC-9219-2020; yilmaz,
   adnan/ABB-9340-2020; Mercantepe, Filiz/GLR-2648-2022
OI ciftel, serpil/0000-0001-6962-4039; mercantepe,
   tolga/0000-0002-8506-1755; Klisic, Aleksandra/0000-0001-7870-0996;
   ciftel, sedat/0000-0003-4905-1944; yilmaz, adnan/0000-0003-4842-1173;
   Mercantepe, Filiz/0000-0002-4325-1534
FU Recep Tayyip Erdogan University Development Foundation; 
   [02024009030096]
FX The Recep Tayyip Erdogan University Development Foundation provided
   funding for the open access publishing of this study (Grant number:
   02024009030096).
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NR 56
TC 1
Z9 1
U1 8
U2 8
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2075-1729
J9 LIFE-BASEL
JI Life-Basel
PD OCT
PY 2024
VL 14
IS 10
AR 1283
DI 10.3390/life14101283
PG 13
WC Biology; Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics; Microbiology
GA K4J5Z
UT WOS:001343556700001
PM 39459583
OA gold
DA 2025-06-11
ER

PT J
AU Gao, ZY
   Xiu, MH
   Liu, JH
   Wu, FC
   Zhang, XY
AF Gao, Zhiyong
   Xiu, Meihong
   Liu, Jiahong
   Wu, Fengchun
   Zhang, Xiang-Yang
TI Obesity, antioxidants and negative symptom improvement in first-episode
   schizophrenia patients treated with risperidone
SO SCHIZOPHRENIA
LA English
DT Article
ID OXIDATIVE STRESS MARKERS; 1ST EPISODE PSYCHOSIS; SUPEROXIDE-DISMUTASE;
   METABOLIC SYNDROME; WEIGHT-GAIN; ASSOCIATION; METAANALYSIS; PREVALENCE;
   CLOZAPINE; PSYCHOPATHOLOGY
AB Negative symptoms remain a main therapeutic challenge in patients with schizophrenia (SZ). Obesity is associated with more severe negative symptoms after the first episode of psychosis. Oxidative stress caused by an impaired antioxidant defense system is involved in the pathophysiology of SZ. Yet, it is unclear regarding the role of obesity and antioxidants in negative symptom improvements in SZ. Therefore, this longitudinal study was designed to assess the impact of obesity on antioxidant defenses and negative symptom improvements in first-episode SZ patients. A total of 241 medication-naive and first-episode patients with SZ were treated with risperidone for 3 months. Outcome measures including symptoms, body weight, and total antioxidant status (TAS) levels were measured at baseline and the end of the third month. We found that after 12 weeks of treatment with risperidone, the body weight increased and clinical symptoms significantly improved. Baseline body mass index (BMI) was negatively correlated with negative symptom improvement after treatment and an increase in TAS was negatively associated with an increase in BMI only in the high BMI group. More importantly, the TAS x BMI interaction at baseline was an independent predictor of negative symptom improvement. Our longitudinal study indicates that the improvement in negative symptoms by risperidone was associated with baseline BMI and TAS levels in patients with SZ. Baseline BMI and TAS may be a predictor for negative improvement in SZ patients after risperidone treatment.
C1 [Gao, Zhiyong; Liu, Jiahong] Wenzhou Med Univ, Zhejiang Prov Clin Res Ctr Mental Disorder, Affiliated Kangning Hosp, Wenzhou, Peoples R China.
   [Xiu, Meihong] Peking Univ, Beijing HuiLongGuan Hosp, HuiLongGuan Clin Med Sch, Beijing, Peoples R China.
   [Wu, Fengchun; Zhang, Xiang-Yang] Guangzhou Med Univ, Dept Psychiat, Affiliated Brain Hosp, Guangzhou, Peoples R China.
   [Wu, Fengchun] Guangdong Engn Technol Res Ctr Translat Med Mental, Guangzhou, Peoples R China.
   [Zhang, Xiang-Yang] Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China.
C3 Wenzhou Medical University; Peking University; Guangzhou Medical
   University
RP Wu, FC; Zhang, XY (corresponding author), Guangzhou Med Univ, Dept Psychiat, Affiliated Brain Hosp, Guangzhou, Peoples R China.; Wu, FC (corresponding author), Guangdong Engn Technol Res Ctr Translat Med Mental, Guangzhou, Peoples R China.; Zhang, XY (corresponding author), Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China.
EM 13580380071@163.com; zhangxy9@gmail.com
RI Zhang, yicheng/HNC-5513-2023; Wu, Fengchun/JBR-9982-2023; Zhang,
   Xiangyang/ABC-7380-2022
OI Zhang, Xiangyang/0000-0003-3326-382X
FU National Key Research and Development Program of China [2021YFC2009403];
   Science and Technology Program of Guangzhou [202206060005]; Guangdong
   Basic and Applied Basic Research Foundation Outstanding Youth Project
   [2021B1515020064]
FX This study was supported by grants from the National Key Research and
   Development Program of China (2021YFC2009403), the Science and
   Technology Program of Guangzhou (202206060005), and the Guangdong Basic
   and Applied Basic Research Foundation Outstanding Youth Project
   (2021B1515020064).
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NR 74
TC 4
Z9 5
U1 1
U2 11
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
EI 2754-6993
J9 SCHIZOPHRENIA-UK
JI Schizophr.
PD MAR 23
PY 2023
VL 9
IS 1
AR 17
DI 10.1038/s41537-023-00346-z
PG 6
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychiatry
GA A0OB7
UT WOS:000952198700001
PM 36949120
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Giordo, R
   Wehbe, Z
   Posadino, AM
   Erre, GL
   Eid, AH
   Mangoni, AA
   Pintus, G
AF Giordo, Roberta
   Wehbe, Zena
   Posadino, Anna Maria
   Erre, Gian Luca
   Eid, Ali H.
   Mangoni, Arduino A.
   Pintus, Gianfranco
TI Disease-Associated Regulation of Non-Coding RNAs by Resveratrol:
   Molecular Insights and Therapeutic Applications
SO FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
LA English
DT Review
DE non-coding RNAs; ncRNAs; resveratrol; atherosclerosis; diabetes;
   obesity; cancer
ID OVARIAN-CANCER CELLS; HIGH-FAT DIET; INSULIN-RESISTANCE; METABOLIC
   SYNDROME; LIVER FIBROSIS; UP-REGULATION; PROSTATE; MODULATION;
   PROLIFERATION; TUMORIGENESIS
AB There have been significant advances, particularly over the last 20 years, in the identification of non-coding RNAs (ncRNAs) and their pathophysiological role in a wide range of disease states, particularly cancer and other chronic conditions characterized by excess inflammation and oxidative stress such as atherosclerosis, diabetes, obesity, multiple sclerosis, osteoporosis, liver and lung fibrosis. Such discoveries have potential therapeutic implications as a better understanding of the molecular mechanisms underpinning the effects of ncRNAs on critical homeostatic control mechanisms and biochemical pathways might lead to the identification of novel druggable targets. In this context, increasing evidence suggests that several natural compounds can target ncRNAs at different levels and, consequently, influence processes involved in the onset and progression of disease states. The natural phenol resveratrol has been extensively studied for therapeutic purposes in view of its established anti-inflammatory and antioxidant effects, particularly in disease states such as cancer and cardiovascular disease that are associated with human aging. However, increasing in vitro and in vivo evidence also suggests that resveratrol can directly target various ncRNAs and that this mediates, at least in part, its potential therapeutic effects. This review critically appraises the available evidence regarding the resveratrol-mediated modulation of different ncRNAs in a wide range of disease states characterized by a pro-inflammatory state and oxidative stress, the potential therapeutic applications, and future research directions.
C1 [Giordo, Roberta] Mohammed Bin Rashid Univ Med & Hlth Sci, Coll Med, Dubai, U Arab Emirates.
   [Wehbe, Zena] Univ London, Mol & Clin Res Inst, Vasc Biol Res Ctr, London, England.
   [Posadino, Anna Maria; Pintus, Gianfranco] Univ Sassari, Dept Biomed Sci, Sassari, Italy.
   [Erre, Gian Luca] Univ Sassari, Univ Hosp AOUSS, Dept Clin & Expt Med, Rheumatol Unit, Sassari, Italy.
   [Eid, Ali H.] QU Hlth Qatar Univ, Coll Med, Dept Basic Med Sci, Doha, Qatar.
   [Mangoni, Arduino A.] Flinders Univ S Australia, Coll Med & Publ Hlth, Discipline Clin Pharmacol, Adelaide, SA, Australia.
   [Mangoni, Arduino A.] Flinders Med Ctr, Dept Clin Pharmacol, Adelaide, SA, Australia.
   [Pintus, Gianfranco] Univ Sharjah, Sharjah Inst Med Res, Coll Hlth Sci, Dept Med Lab Sci, Sharjah, U Arab Emirates.
C3 University of London; University of Sassari; University of Sassari;
   Qatar University; Flinders University South Australia; Flinders Medical
   Centre; University of Sharjah
RP Pintus, G (corresponding author), Univ Sassari, Dept Biomed Sci, Sassari, Italy.; Mangoni, AA (corresponding author), Flinders Univ S Australia, Coll Med & Publ Hlth, Discipline Clin Pharmacol, Adelaide, SA, Australia.; Mangoni, AA (corresponding author), Flinders Med Ctr, Dept Clin Pharmacol, Adelaide, SA, Australia.; Pintus, G (corresponding author), Univ Sharjah, Sharjah Inst Med Res, Coll Hlth Sci, Dept Med Lab Sci, Sharjah, U Arab Emirates.
EM arduino.mangoni@flinders.edu.au; gpintus@uniss.it
RI Posadino, Anna Maria/LGZ-1717-2024; Eid, Ali/ABD-6291-2021; Pintus,
   Gianfranco/C-2975-2009; Mangoni, Arduino/F-8000-2010; Giordo,
   Roberta/AEB-6969-2022; Erre, Gian Luca/C-7907-2017
OI Erre, Gian Luca/0000-0001-6818-7666; Posadino, Anna
   Maria/0000-0002-6155-159X
FU Progetto Fondazione di Sardegna-bando; University of Sharjah
   [2101050160]
FX This work has been made possible thanks to grants from (Progetto
   Fondazione di Sardegna--bando 2022-2023 and FAR2020-Pintus) to GP and
   the (University of Sharjah Collaborative 2101050160) to GP and AM.
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NR 138
TC 26
Z9 26
U1 2
U2 15
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-634X
J9 FRONT CELL DEV BIOL
JI Front. Cell. Dev. Biol.
PD JUL 13
PY 2022
VL 10
AR 894305
DI 10.3389/fcell.2022.894305
PG 14
WC Cell Biology; Developmental Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Developmental Biology
GA 3I5YB
UT WOS:000832790800001
PM 35912113
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Badavi, M
   Mard, SA
   Dianat, M
   Dashtbozorgi, N
AF Badavi, Mohammad
   Mard, Seyyed Ali
   Dianat, Mahin
   Dashtbozorgi, Neda
TI Crocin attenuates oxidative stress and inflammation in myocardial
   infarction induced by isoprenaline via PPARγ activation in diabetic rats
SO JOURNAL OF DIABETES AND METABOLIC DISORDERS
LA English
DT Article
DE Crocin; Myocardial infarction; Inflammation; PPAR gamma; Rat
ID ISCHEMIA-REPERFUSION INJURY; INSULIN-RESISTANCE; INDUCED CARDIOTOXICITY;
   METABOLIC SYNDROME; LIPID PROFILE; ANTIOXIDANT; RECEPTOR; SAFFRON;
   CONSTITUENT; SATIVUS
AB Background and purpose Hyperglycemia induced oxidative stress and inflammation lead to development of diabetic cardiomyopathy. Diabetic patients are more at risk for myocardial infarction than non-diabetics. The current study has investigated the involvement of PPAR gamma activation in effects of crocin as a natural carotenoid against cardiac infarction in diabetic rats.
   Materials and methods Diabetes was induced in male Wistar rats by streptozotocin injection (55 mg/kg, i.p) 15 min after the administration of nicotinamide (110 mg/kg). Then saline, crocin (40 mg/kg, orally) and GW9662 (1 mg/kg, as PPAR gamma antagonist) were injected for 4 weeks. Isoprenaline was administrated on the 27th and 28th days to induce infarction. Cardiac injury markers, antioxidant enzymes content, blood glucose level, lipid profile, pro and anti-inflammatory cytokines, and PPAR gamma gene expression were measured.
   Results GSH, CAT content, CK-MB isoenzyme, LDH level, IL-10 and PPAR gamma gene expression in myocardial tissue were decreased in diabetic rats receiving isoprenaline and inflammatory cytokines TNF alpha and IL-6 and also plasma lipids were increased. Crocin administration significantly ameliorated inflammatory cytokines levels, CK-MB, and LDH contents and also it could enhance antioxidant capacity and PPAR gamma expression. However, GW9662 administration reversed the effects of crocin.
   Conclusion Overexpression of PPAR gamma in crocin treated rats and inhibition of crocin effects by GW9662 reflected the potential involvement of PPAR gamma pathway in the protective effects of crocin.
C1 [Badavi, Mohammad; Mard, Seyyed Ali; Dianat, Mahin; Dashtbozorgi, Neda] Ahvaz Jundishapur Univ Med Sci, Ahvaz Physiol Res Ctr, Ahvaz, Iran.
   [Badavi, Mohammad; Mard, Seyyed Ali; Dianat, Mahin; Dashtbozorgi, Neda] Ahvaz Jundishapur Univ Med Sci, Sch Med, Dept Physiol, Ahvaz, Iran.
   [Mard, Seyyed Ali] Imam Khomeini Hosp, Alimentary Tract Res Ctr, Clin Res Dev Unit, Ahvaz, Iran.
C3 Ahvaz Jundishapur University of Medical Sciences (AJUMS); Ahvaz
   Jundishapur University of Medical Sciences (AJUMS)
RP Dashtbozorgi, N (corresponding author), Ahvaz Jundishapur Univ Med Sci, Ahvaz Physiol Res Ctr, Ahvaz, Iran.; Dashtbozorgi, N (corresponding author), Ahvaz Jundishapur Univ Med Sci, Sch Med, Dept Physiol, Ahvaz, Iran.
EM n.dashtbozorgi@gmail.com
RI Dianat, Mahin/H-2370-2016; Badavi, Mohammad/C-1452-2013; Mard,
   Seyed/ABF-5973-2020
FU Physiology Research Center of Ahvaz Jundishapur University of Medical
   Sciences [APRC-9702]
FX This study was supported by funds received from the Physiology Research
   Center of Ahvaz Jundishapur University of Medical Sciences (Grant No.
   APRC-9702).
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NR 48
TC 13
Z9 15
U1 0
U2 7
PU SPRINGER INT PUBL AG
PI CHAM
PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND
EI 2251-6581
J9 J DIABETES METAB DIS
JI J. Diabetes Metab. Disord.
PD DEC
PY 2020
VL 19
IS 2
BP 1517
EP 1525
DI 10.1007/s40200-020-00686-y
EA NOV 2020
PG 9
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA QC8UX
UT WOS:000592780900001
PM 33553037
OA Green Published
DA 2025-06-11
ER

PT J
AU Domingos, ALG
   Hermsdorff, HHM
   Bressan, J
AF Gomes Domingos, Ana Luiza
   Miranda Hermsdorff, Helen Hermana
   Bressan, Josefina
TI Melatonin intake and potential chronobiological effects on human health
SO CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
LA English
DT Review
DE Food analysis; Food composition; Food intake; Melatonin; Nutritional
   sciences
ID URINARY 6-SULFATOXYMELATONIN; OXIDATIVE STRESS; INDOLE COMPOUNDS; SLEEP;
   CONSUMPTION; PARAMETERS; ORANGE; GRAPE
AB Melatonin is an indolamine with a recognized chronobiotic role. In turn, the supplementation of melatonin through capsules has been shown to be efficient in the modulation of inflammatory markers, oxidative stress, as well as in the control of hypertension and metabolic syndrome. However, the science of nutrition is interested in the study of the food sources of this hormone and its possible therapeutic effects. Thus, this review aimed to identify and present scientific papers that quantified melatonin in foods and evaluated its application in intervention studies. In total, 278 studies were found, of which 17 were included in this review. The results show that meats, fish, eggs, cereals, tubers, oilseeds, mushrooms, fruits, vegetables, alcoholic and non-alcoholic beverages and dairy products had some items analyzed for their melatonin concentrations. The concentrations reported presented considerable amplitude among different foods and even within the same species, possibly due to differences in cultivation and different hormonal dosing techniques. Also, different concentrations of melatonin can be presented for the same food when submitted to processes such as cooking, roasting or fermentation. The intervention studies presented positive results regarding the consumption of foods rich in melatonin and clinical-metabolic indicators. However, in order to guide nutritional behavior, it is necessary to consult a composition table that makes melatonin concentrations available and considers the processes involved in the preparation of the food. With this table, it will be possible to analyze the real effect of habitual consumption of melatonin from food on health.
C1 [Gomes Domingos, Ana Luiza; Miranda Hermsdorff, Helen Hermana; Bressan, Josefina] Univ Fed Vicosa, Dept Nutr & Hlth, Av PH Rolfs S-N, BR-36570000 Vicosa, MG, Brazil.
C3 Universidade Federal de Vicosa
RP Bressan, J (corresponding author), Univ Fed Vicosa, Dept Nutr & Hlth, Av PH Rolfs S-N, BR-36570000 Vicosa, MG, Brazil.
EM jbrm@ufv.br
RI Bressan, Josefina/A-2598-2009; Gomes Domingos, Ana Luiza/R-2956-2018;
   Hermsdorff, Helen Hermana Miranda/H-4525-2015
OI Bressan, Josefina/0000-0002-4993-9436; Gomes Domingos, Ana
   Luiza/0000-0001-7010-0574; Hermsdorff, Helen Hermana
   Miranda/0000-0002-4441-6572
FU CAPES (Ministry of Education, Brazil)
FX We thank CAPES (Ministry of Education, Brazil) for granting a doctoral
   fellowship to ALG Domingos. HHM Hermsdorff and JBressan are Research
   Productivity fellows - CNPq.
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NR 37
TC 25
Z9 26
U1 2
U2 48
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1040-8398
EI 1549-7852
J9 CRIT REV FOOD SCI
JI Crit. Rev. Food Sci. Nutr.
PD JAN 2
PY 2019
VL 59
IS 1
BP 133
EP 140
DI 10.1080/10408398.2017.1360837
PG 8
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA HM9PP
UT WOS:000459817600010
PM 28799779
DA 2025-06-11
ER

PT J
AU Bhatraju, NK
   Agrawal, A
AF Bhatraju, Naveen K.
   Agrawal, Anurag
TI Mitochondrial Dysfunction Linking Obesity and Asthma
SO ANNALS OF THE AMERICAN THORACIC SOCIETY
LA English
DT Article; Proceedings Paper
CT 32nd Annual Transatlantic Airway Conference on Lung Diseases
CY JAN 18-20, 2017
CL Lucerne, SWITZERLAND
DE mitochondria; asthma; lung; diabetes; metabolic syndrome
ID INSULIN-RESISTANCE; CLUSTER-ANALYSIS; INFLAMMATION; ASSOCIATION;
   IDENTIFICATION; INTERFACE; STRESS
AB The bidirectional epidemiological association between asthma and obesity is well known. Recent evidence suggests that there is an intersection of the pathophysiological molecular pathways leading to either obesity or asthma, at the level of mitochondria. This is not surprising, because mitochondria, beyond their roles as the metabolic powerhouses of the cell, serve as sensors of threats, regulators of stress signaling, and effectors of cytotoxicity. Reduced mitochondrial function and low metabolic activity are well-recognized features of obesity. Three distinct lines of experimental evidences connect mitochondrial dysfunction with asthma. First, asthma is associated with aberrant mitochondrial metabolism. Second, mitochondrial dysfunction may either induce asthma-like features or increase asthma severity. Third, mitochondria-targeted therapies appear effective in preventing or reversing asthma features. Importantly, mitochondrial dysfunction in airway epithelial cells appears to be a powerful trigger for airway remodeling that is independent of cellular inflammation. This is clinically relevant to the obese-asthma phenotype, with exaggerated symptoms despite apparently low levels of inflammation, and poor response to anti-inflammatory treatment. In summary, mitochondrial dysfunction is a common thread tying together the twin epidemics of obesity and asthma. Environmental and lifestyle factors leading to primary mitochondrial dysfunction may be increasing the risk for either disease. Further, secondary mitochondrial dysfunction emerging from the pathogenesis of either obesity or asthma may increase the risk of the other. Mitochondrial health-centric strategies may be relevant to prevention and treatment of both obesity and asthma, and should be actively considered.
C1 [Bhatraju, Naveen K.; Agrawal, Anurag] CSIR, Inst Genom & Integrat Biol, Mall Rd, Delhi 110007, India.
   [Agrawal, Anurag] Acad Sci & Innovat Res, Delhi, India.
   [Agrawal, Anurag] Baylor Coll Med, Houston, TX 77030 USA.
C3 Council of Scientific & Industrial Research (CSIR) - India; CSIR -
   Institute of Genomics & Integrative Biology (IGIB); Academy of
   Scientific & Innovative Research (AcSIR); Baylor College of Medicine
RP Agrawal, A (corresponding author), CSIR, Inst Genom & Integrat Biol, Mall Rd, Delhi 110007, India.
EM a.agrawal@igib.in
RI Agrawal, Anurag/GZL-5821-2022
OI Agrawal, Anurag/0000-0002-0340-5252; Bhatraju, Naveen
   Kumar/0000-0002-6248-7956
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NR 50
TC 31
Z9 33
U1 2
U2 22
PU AMER THORACIC SOC
PI NEW YORK
PA 25 BROADWAY, 18 FL, NEW YORK, NY 10004 USA
SN 1546-3222
EI 2325-6621
J9 ANN AM THORAC SOC
JI Ann. Am. Thoracic Society
PD NOV
PY 2017
VL 14
SU 5
BP S368
EP S373
DI 10.1513/AnnalsATS.201701-042AW
PG 6
WC Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Respiratory System
GA FN3HN
UT WOS:000415888800011
PM 29161084
DA 2025-06-11
ER

PT J
AU Martino, F
   Magenta, A
   Pannarale, G
   Martino, E
   Zanoni, C
   Perla, FM
   Puddu, PE
   Barillà, F
AF Martino, Francesco
   Magenta, Alessandra
   Pannarale, Giuseppe
   Martino, Eliana
   Zanoni, Cristina
   Perla, Francesco M.
   Puddu, Paolo E.
   Barilla, Francesco
TI Epigenetics and cardiovascular risk in childhood
SO JOURNAL OF CARDIOVASCULAR MEDICINE
LA English
DT Review
DE cardiovascular disease; epigenetics; methylation; microRNA; pediatric
ID OXIDATIVE STRESS; MATERNAL HYPERCHOLESTEROLEMIA; CHOLESTEROL
   HOMEOSTASIS; REGULATORY FUNCTIONS; METABOLIC SYNDROME; DNA METHYLATION;
   DOWN-REGULATION; 7 COUNTRIES; IN-UTERO; ATHEROSCLEROSIS
AB Cardiovascular disease (CVD) can arise at the early stages of development and growth. Genetic and environmental factors may interact resulting in epigenetic modifications with abnormal phenotypic expression of genetic information without any change in the nucleotide sequence of DNA. Maternal dietary imbalance, inadequate to meet the nutritional needs of the fetus can lead to intrauterine growth retardation, decreased gestational age, low birth weight, excessive post-natal growth and metabolic alterations, with subsequent appearance of CVD risk factors. Fetal exposure to high cholesterol, diabetes and maternal obesity is associated with increased risk and progression of atherosclerosis. Maternal smoking during pregnancy and exposure to various environmental pollutants induce epigenetic alterations of gene expression relevant to the onset or progression of CVD. In children with hypercholesterolemia and/or obesity, oxidative stress activates platelets and monocytes, which release proinflammatory and proatherogenic substances, inducing endothelial dysfunction, decreased Doppler flow-mediated dilation and increased carotid intima-media thickness. Primary prevention of atherosclerosis should be implemented early. It is necessary to identify, through screening, high-risk apparently healthy children and take care of them enforcing healthy lifestyle (mainly consisting of Mediterranean diet and physical activity), prescribing nutraceuticals and eventual medications, if required by a high-risk profile. The key issue is the restoration of endothelial function in the reversible stage of atherosclerosis. Epigenetics may provide new markers for an early identification of children at risk and thereby develop innovative therapies and specific nutritional interventions in critical times.
C1 [Martino, Francesco; Martino, Eliana; Zanoni, Cristina; Perla, Francesco M.] Univ Roma La Sapienza, Dept Pediat & Child Neuropsychiat, Rome, Italy.
   [Magenta, Alessandra] Ist Dermopat Immacolata IRCCS, Fdn Luigi Monti, Vasc Pathol Lab, Rome, Italy.
   [Pannarale, Giuseppe; Puddu, Paolo E.; Barilla, Francesco] Univ Roma La Sapienza, Dept Cardiovasc Resp Nephrol Anesthesiol & Geriat, Rome, Italy.
C3 Sapienza University Rome; IRCCS Istituto Dermopatico dell'Immacolata
   (IDI); Sapienza University Rome
RP Barillà, F (corresponding author), Univ Roma La Sapienza, Dept Cardiovasc Resp Nephrol Anesthesiol & Geriat, Rome, Italy.
EM francesco.barilla@uniroma1.it
RI Puddu, Paolo/G-6180-2012; magenta, alessandra/A-9473-2017; BARILLA',
   Francesco/Q-2665-2016
OI Martino, Francesco/0000-0002-0368-1994; BARILLA',
   Francesco/0000-0003-0594-7212; Puddu, Paolo Emilio/0000-0002-6191-7838
FU Ministero della Salute [GR-2010-2309531]
FX This study was partly supported by Ministero della Salute
   GR-2010-2309531 to A.M.
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NR 72
TC 23
Z9 24
U1 0
U2 36
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1558-2027
EI 1558-2035
J9 J CARDIOVASC MED
JI J. Cardiovasc. Med.
PD AUG
PY 2016
VL 17
IS 8
BP 539
EP 546
DI 10.2459/JCM.0000000000000334
PG 8
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA DS1II
UT WOS:000380348700001
PM 27367935
DA 2025-06-11
ER

PT J
AU Li, JH
   Sapper, TN
   Mah, E
   Rudraiah, S
   Schill, KE
   Chitchumroonchokchai, C
   Moller, MV
   McDonald, JD
   Rohrer, PR
   Manautou, JE
   Bruno, RS
AF Li, Jinhui
   Sapper, Teryn N.
   Mah, Eunice
   Rudraiah, Swetha
   Schill, Kevin E.
   Chitchumroonchokchai, Chureeporn
   Moller, Meredith V.
   McDonald, Joshua D.
   Rohrer, Philip R.
   Manautou, Jose E.
   Bruno, Richard S.
TI Green tea extract provides extensive Nrf2-independent protection against
   lipid accumulation and NFB pro- inflammatory responses during
   nonalcoholic steatohepatitis in mice fed a high-fat diet
SO MOLECULAR NUTRITION & FOOD RESEARCH
LA English
DT Article
DE Green tea; Inflammation; NASH; Nrf2; Oxidative stress
ID KAPPA-B ACTIVATION; LIVER-DISEASE; HEPATIC STEATOSIS; GENE-EXPRESSION;
   NRF2-MEDIATED ANTIOXIDANT; METABOLIC SYNDROME; OXIDATIVE STRESS; OBESE
   MICE; TNF-ALPHA; NRF2
AB ScopeGreen tea extract (GTE) reduces liver steatosis and inflammation during nonalcoholic steatohepatitis (NASH). We hypothesized GTE would mitigate NASH in a nuclear factor erythroid-2-related-factor-2 (Nrf2)-dependent manner in a high fat (HF) induced model.
   Methods and resultsNrf2-null and wild-type (WT) mice were fed an HF diet containing 0 or 2% GTE for eight weeks prior to assessing parameters of NASH. Compared to WT mice, Nrf2-null mice had increased serum alanine aminotransferase, hepatic triglyceride, expression of free fatty acid uptake and lipogenic genes, malondialdehyde and NFB phosphorylation and expression of pro-inflammatory genes. In WT mice, GTE increased Nrf2 and NADPH:quinone oxidoreductase-1 mRNA, and lowered hepatic steatosis, lipid uptake and lipogenic gene expression, malondialdehyde, and NFB-dependent inflammation. In Nrf2-null mice, GTE lowered NFB phosphorylation and TNF- and MCP1 mRNA to levels observed in WT mice fed GTE whereas hepatic triglyceride and lipogenic genes were lowered only to those of WT mice fed no GTE. Malondialdehyde was lowered in Nrf2-null mice fed GTE, but not to levels of WT mice, and without improving the hepatic antioxidants -tocopherol, ascorbic acid and uric acid.
   ConclusionNrf2 deficiency exacerbates NASH whereas anti-inflammatory and hypolipidemic activities of GTE likely occur largely independent of Nrf2 signaling.
C1 [Li, Jinhui; Sapper, Teryn N.; Mah, Eunice; Schill, Kevin E.; Chitchumroonchokchai, Chureeporn; Moller, Meredith V.; McDonald, Joshua D.; Bruno, Richard S.] Ohio State Univ, Human Nutr Program, Columbus, OH 43210 USA.
   [Mah, Eunice] Biofortis Inc, Addison, IL USA.
   [Rudraiah, Swetha; Rohrer, Philip R.; Manautou, Jose E.] Univ Connecticut, Dept Pharmaceut Sci, Storrs, CT USA.
C3 University System of Ohio; Ohio State University; University of
   Connecticut
RP Bruno, RS (corresponding author), Ohio State Univ, Human Nutr Program, Columbus, OH 43210 USA.
EM Bruno.27@osu.edu
RI Bruno, Richard/K-1930-2012
OI Bruno, Richard/0000-0002-6772-2038
FU USDA-NIFA [2014-67017-21761]; Ohio State University (OSU) Food
   Innovation Center; Molecular Carcinogenesis and Chemoprevention Program
   of the OSU Comprehensive Cancer (National Institutes of Health, National
   Cancer Institute) [P30CA16058]; OSU Center for Advanced Functional Foods
   Research and Entrepreneurship; NIFA [687115, 2014-67017-21761] Funding
   Source: Federal RePORTER
FX This work was supported by grants to R.S.B. from USDA-NIFA
   (2014-67017-21761), The Ohio State University (OSU) Food Innovation
   Center, the Molecular Carcinogenesis and Chemoprevention Program of the
   OSU Comprehensive Cancer (National Institutes of Health, National Cancer
   Institute P30CA16058) and the OSU Center for Advanced Functional Foods
   Research and Entrepreneurship as well as state and federal funds
   appropriated to the OSU Ohio Agricultural Research and Development
   Center.
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NR 61
TC 59
Z9 70
U1 0
U2 36
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1613-4125
EI 1613-4133
J9 MOL NUTR FOOD RES
JI Mol. Nutr. Food Res.
PD APR
PY 2016
VL 60
IS 4
BP 858
EP 870
DI 10.1002/mnfr.201500814
PG 13
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA DJ4BQ
UT WOS:000374150800014
PM 26679056
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Mahadev, K
   Wu, XD
   Donnelly, S
   Ouedraogo, R
   Eckhart, AD
   Goldstein, BJ
AF Mahadev, Kalyankar
   Wu, Xiangdong
   Donnelly, Sylvia
   Ouedraogo, Raogo
   Eckhart, Andrea D.
   Goldstein, Barry J.
TI Adiponectin inhibits vascular endothelial growth factor-induced
   migration of human coronary artery endothelial cells
SO CARDIOVASCULAR RESEARCH
LA English
DT Article
DE adiponectin; acrp30; VEGF; endothelium; reactive oxygen species;
   apoptosis; focal adhesions; actin stress fibres; RhoA
ID SMOOTH-MUSCLE-CELLS; NF-KAPPA-B; REACTIVE OXYGEN; METABOLIC SYNDROME;
   NADPH OXIDASE; MITOCHONDRIAL SUPEROXIDE; CARDIOVASCULAR-DISEASE;
   SIGNAL-TRANSDUCTION; ADHESION MOLECULES; INSULIN-RESISTANCE
AB Aims Vascular endothelial growth factor (VEGF)-induced endothelial cell migration and angiogenesis are associated with the vascular complications of diabetes mellitus, and adiponectin is an abundant plasma adipokine that exhibits salutary effects on endothelial function. We investigated whether adiponectin suppresses VEGF-induced migration and related signal transduction responses in human coronary artery endothelial cells (HCAECs).
   Methods and results Using a modified Boyden chamber technique and a monolayer 'wound-healing' assay, both the recombinant adiponectin globular domain and full-length adiponectin protein potently suppressed the migration of HCAEC induced by VEGF. Adiponectin did not increase endothelial. cell apoptosis, as measured by Terminal deoxynucleotidyl Transferase Biotin-dUTP Nick End Labelling assay. Adiponectin also suppressed VEGF-induced reactive oxygen species generation, activation of Akt, the mitogen-activated protein kinase ERK and the RhoGTPase RhoA, and induction of the formation of actin stress fibres and focal cellular adhesions. VEGF-stimulated cell migration was inhibited by activation of adenylyl cyclase with forskolin, and adiponectin treatment increased cellular cyclic adenosine monophosphate (cAMP) levels and protein kinase A (PKA) enzymatic activity. Pharmacological inhibition of either adenylyl cyclase or PKA significantly abrogated the effect of adiponectin globular domain to suppress VEGF-induced cell migration.
   Conclusion Adiponectin suppresses VEGF-stimulated HCAEC migration via cAMP/PKA-dependent signalling, an important effect with implications for a regulatory rote of adiponectin in vascular processes associated with diabetes and atherosclerosis.
C1 [Mahadev, Kalyankar; Wu, Xiangdong; Donnelly, Sylvia; Ouedraogo, Raogo; Goldstein, Barry J.] Thomas Jefferson Univ, Jefferson Med Coll, Div Endocrinol Diabet & Metab Dis, Dept Med, Philadelphia, PA 19107 USA.
   [Eckhart, Andrea D.] Thomas Jefferson Univ, Jefferson Med Coll, Dept Med, Ctr Translat Med,Eugene Feiner Lab Vasc Biol & Th, Philadelphia, PA 19107 USA.
C3 Thomas Jefferson University; Thomas Jefferson University
RP Mahadev, K (corresponding author), Thomas Jefferson Univ, Jefferson Med Coll, Div Endocrinol Diabet & Metab Dis, Dept Med, Suite 320,Curtis Bldg,1015 Walnut St, Philadelphia, PA 19107 USA.
EM mahadev.kalyankar@jefferson.edu; barry.goldstein@jefferson.edu
OI Kalyankar, Mahadev/0000-0002-8628-1944
FU NIDDK NIH HHS [DK63018, DK71360] Funding Source: Medline
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NR 43
TC 86
Z9 103
U1 0
U2 11
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0008-6363
J9 CARDIOVASC RES
JI Cardiovasc. Res.
PD MAY 1
PY 2008
VL 78
IS 2
BP 376
EP 384
DI 10.1093/cvr/cvn034
PG 9
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 300FD
UT WOS:000255808800022
PM 18267956
OA Bronze
DA 2025-06-11
ER

PT J
AU Yeo, H
   Lim, JH
   Eom, J
   Kim, M
   Kwon, H
   Kang, SW
   Song, Y
AF Yeo, Hyejin
   Lim, Ji-Hye
   Eom, Ji
   Kim, Minjeong
   Kwon, Hyeji
   Kang, Sang-Wook
   Song, Youngsup
TI Diet-induced obesity and aging-induced upregulation of Trib3 interfere
   with energy homeostasis by downregulating the thermogenic capacity of
   BAT
SO EXPERIMENTAL AND MOLECULAR MEDICINE
LA English
DT Article
ID TRIBBLES HOMOLOG 3; INSULIN-RESISTANCE; ADIPOCYTE DIFFERENTIATION;
   ADIPOSE-TISSUE; RETICULUM STRESS; TRB3 LINKS; ER STRESS; BROWN FAT;
   PROTEIN; MUSCLE
AB Characterized by UCP1 expression and abundant mitochondria, brown adipose tissue (BAT) plays a crucial role in energy balance by converting chemical energy into heat through the cost of ATP production. In this study, it was demonstrated that Trib3 is a critical determinant of BAT-mediated energy expenditure and whole-body energy homeostasis. Under 60% high-fat diet conditions, Trib3 expression in BAT was elevated. Mice deficient in Trib3 are resistant to diet-induced obesity and exhibit improved glucose homeostasis due to enhanced BAT activity. Furthermore, brown adipocyte progenitor cells (APCs) lacking Trib3 exhibited increased proliferation and promoted brown adipocyte differentiation and mitochondrial biogenesis, contributing to the increase in the maximal thermogenic capacity of BAT in Trib3-deficient mice. Mechanistically, it was discovered that Trib3 expression is upregulated by free fatty acids at the transcriptional level and synergistically upregulated by DAG-PKC at the posttranslational level. This occurs through the modulation of COP1-mediated Trib3 protein turnover. Interestingly, the level of Trib3 expression in BAT increased with age. Trib3 knockout mice were protected from aging-related weight gain and impaired glucose homeostasis. These results suggest that Trib3 acts as an obesity- and aging-associated factor that negatively regulates BAT activity and that the loss of Trib3 may provide a beneficial approach to prevent obesity and aging-associated metabolic syndrome by increasing the thermogenic capacity of BAT.
C1 [Yeo, Hyejin; Lim, Ji-Hye; Eom, Ji; Kim, Minjeong; Kwon, Hyeji; Song, Youngsup] Univ Ulsan, Asan Med Ctr, Dept Brain Sci, Brain Korea Project 21,Coll Med, Seoul, South Korea.
   [Kang, Sang-Wook] Univ Ulsan, Asan Med Ctr, Coll Med, Dept Biochem & Mol Biol,Brain Korea Project 21, Seoul 138736, South Korea.
C3 University of Ulsan; Asan Medical Center; University of Ulsan; Asan
   Medical Center
RP Song, Y (corresponding author), Univ Ulsan, Asan Med Ctr, Dept Brain Sci, Brain Korea Project 21,Coll Med, Seoul, South Korea.
EM ysong@amc.seoul.kr
OI Song, Youngsup/0000-0002-6268-5223
FU National Research Foundation of Korea (NRF) [RS-2023-00208426]; National
   Research Foundation of Korea [RS-2460000193]; Ministry of Health &
   Welfare, Republic of Korea [2023IP0128]; Asan Institute for Life
   Sciences; Asan Life Science Institute
FX This study was supported by a grant from the National Research
   Foundation of Korea (RS-2023-00208426), a grant from the Ministry of
   Health & Welfare, Republic of Korea (RS-2460000193) and the Asan
   Institute for Life Sciences (2023IP0128). This paper is dedicated to the
   memory of Kyung-Chul Park, whose significant contributions greatly
   influenced this work. The authors would also like to express their
   gratitude to Min-Seo Kwon for technical support, the Asan Life Science
   Institute and Asan Medical Center (AMC) pathology laboratory for tissue
   processing support and Jin Hwa Jung at the Positron Emission Tomography
   (PET) core, Convergence Medicine Research Center, Asan Institute for
   Life Sciences, for PET analysis.
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NR 60
TC 1
Z9 1
U1 2
U2 2
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 1226-3613
EI 2092-6413
J9 EXP MOL MED
JI Exp. Mol. Med.
PD DEC
PY 2024
VL 56
IS 12
BP 2690
EP 2702
DI 10.1038/s12276-024-01361-5
EA DEC 2024
PG 13
WC Biochemistry & Molecular Biology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Research & Experimental Medicine
GA Q3H3G
UT WOS:001375659400001
PM 39623091
OA gold
DA 2025-06-11
ER

PT J
AU Karimi, A
   Tutunchi, H
   Naeini, F
   Vajdi, M
   Mobasseri, M
   Najafipour, F
AF Karimi, Arash
   Tutunchi, Helda
   Naeini, Fatemeh
   Vajdi, Mahdi
   Mobasseri, Majid
   Najafipour, Farzad
TI The therapeutic effects and mechanisms of action of resveratrol on
   polycystic ovary syndrome: A comprehensive systematic review of
   clinical, animal and in vitro studies
SO CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
LA English
DT Review
DE polycystic ovary syndrome (PCOS); resveratrol; systematic review
ID INSULIN-RESISTANCE; OXIDATIVE STRESS; RAT MODEL; METABOLIC SYNDROME;
   WOMEN; HYPERANDROGENISM; OBESITY; DYSLIPIDEMIA; ANTIOXIDANTS;
   INFLAMMATION
AB Polycystic ovary syndrome (PCOS) is one of the most important and common polygenic endocrine disorders among women of reproductive age. Resveratrol, a natural phenol, is involved in various biological activities, including antioxidant, antiseptic, anti-inflammatory, anti-ageing and anti-cancer effects. This systematic review aimed to investigate the therapeutic effects and mechanisms of actions of resveratrol in PCOS. The present study was conducted according to the guidelines of the Preferred Reporting Items for Systematic Review and Meta-Analysis statements. We searched PubMed, Science Direct, Google Scholar, Scopus, ISI Web of Science, ProQuest and Embase databases up to August 2021 by using the relative keywords. Original studies published in the English language that assessed the effects of resveratrol on PCOS and its associated complications were considered. Out of 417 records screened, only 24 articles met the inclusion criteria: 10 in vitro, 10 animal and 4 human studies. The results obtained in the present study showed that resveratrol supplementation might be effective in improving PCOS-related symptoms by reducing insulin resistance, alleviating dyslipidaemia, improving ovarian morphology and anthropometric indices, regulating the reproductive hormones and reducing inflammation and oxidative stress by affecting biological pathways. According to the available evidence, resveratrol may reduce the complications of PCOS. However, further studies are recommended for a comprehensive conclusion on the exact mechanism of resveratrol in PCOS patients.
C1 [Karimi, Arash] Tabriz Univ Med Sci, Nutr Res Ctr, Sch Nutr & Food Sci, Dept Al Clin Nutr, Tabriz, Iran.
   [Tutunchi, Helda; Mobasseri, Majid; Najafipour, Farzad] Tabriz Univ Med Sci, Endocrine Res Ctr, Tabriz, Iran.
   [Naeini, Fatemeh] Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Clin Nutr, Tehran, Iran.
   [Vajdi, Mahdi] Isfahan Univ Med Sci, Sch Nutr & Food Sci, Dept Clin Nutr, Student Res Comm, Esfahan, Iran.
C3 Tabriz University of Medical Science; Tabriz University of Medical
   Science; Tehran University of Medical Sciences; Isfahan University of
   Medical Sciences
RP Najafipour, F (corresponding author), Tabriz Univ Med Sci, Endocrinol & Metab, Endocrine Res Ctr, Tabriz, Iran.
EM farzadnajafipour@gmail.com
RI Tutunchi, Helda/AAC-1573-2022; Vajdi, Mahdi/GZG-7674-2022; najafipour,
   farzad/M-2686-2017; Karimi, Arash/AAE-4063-2022
OI Karimi, Arash/0000-0001-6407-8286; Vajdi, Mahdi/0000-0002-2828-1161
FU Tabriz University of Medical Sciences
FX The authors would like to thank the Tabriz University of Medical
   Sciencesfor its support.
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NR 80
TC 10
Z9 13
U1 4
U2 12
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0305-1870
EI 1440-1681
J9 CLIN EXP PHARMACOL P
JI Clin. Exp. Pharmacol. Physiol.
PD SEP
PY 2022
VL 49
IS 9
BP 935
EP 949
DI 10.1111/1440-1681.13698
EA JUL 2022
PG 15
WC Pharmacology & Pharmacy; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Physiology
GA 3P1XY
UT WOS:000829757100001
PM 35778955
DA 2025-06-11
ER

PT J
AU Van Hecke, T
   De Vrieze, J
   Boon, N
   De Vos, WH
   Vossen, E
   De Smet, S
AF Van Hecke, Thomas
   De Vrieze, Jo
   Boon, Nico
   De Vos, Winnok H.
   Vossen, Els
   De Smet, Stefaan
TI Combined Consumption of Beef-Based Cooked Mince and Sucrose Stimulates
   Oxidative Stress, Cardiac Hypertrophy, and Colonic Outgrowth of
   Desulfovibrionaceae in Rats
SO MOLECULAR NUTRITION & FOOD RESEARCH
LA English
DT Article
DE chronic disease; colonic microbiota; digestion; oxidation; red meat
ID GRADIENT GEL-ELECTROPHORESIS; POLYUNSATURATED FATTY-ACIDS;
   SUGAR-SWEETENED BEVERAGES; CORONARY-HEART-DISEASE; RED MEAT; METABOLIC
   SYNDROME; METHYL LINOLEATE; LIPID OXIDATION; REDUCING SUGARS; MUCUS
   BARRIER
AB Scope High red meat and sucrose consumption increases the epidemiological risk for chronic diseases. Mechanistic hypotheses include alterations in oxidative status, gut microbiome, fat deposition, and low-grade inflammation. Methods and results For 2 weeks, 40 rats consumed a diet high in white or red meat (chicken-based or beef-based cooked mince, respectively), and containing corn starch or sucrose in a 2 x 2 factorial design. Lard was mixed with lean chicken or beef to obtain comparable dietary fatty acid profiles. Beef (vs chicken)-fed rats had higher lipid oxidation products (malondialdehyde, 4-hydroxy-2-nonenal, and hexanal) in stomach content and blood, and lower blood glutathione. Sucrose (vs corn starch)-fed rats showed increased blood lipid oxidation products and glutathione peroxidase activity, higher liver weight and malondialdehyde concentrations, and mesenterial and retroperitoneal fat accumulation. Beef-sucrose-fed rats had increased cardiac weight, suggesting pathophysiological effects on the cardiovascular system. The colonic microbiome of beef-sucrose-fed rats showed an outgrowth of the sulfate-reducing family of the Desulfovibrionaceae, and lower abundance of the Lactobacillus genus, indicating intestinal dysbiosis. Blood C-reactive protein, a marker for inflammation, was not different among groups. Conclusions Consumption of a cooked beef-based meat product with sucrose increased oxidative stress parameters and promoted cardiac hypertrophy and intestinal dysbiosis.
C1 [Van Hecke, Thomas; Vossen, Els; De Smet, Stefaan] Univ Ghent, Dept Anim Sci & Aquat Ecol, Lab Anim Nutr & Anim Prod Qual, Coupure Links 653, B-9000 Ghent, Belgium.
   [De Vrieze, Jo; Boon, Nico] Univ Ghent, Ctr Microbial Ecol & Technol, Coupure Links 653, B-9000 Ghent, Belgium.
   [De Vos, Winnok H.] Univ Antwerp, Dept Vet Sci, Lab Cell Biol & Histol, Groenenborgerlaan 171, B-2020 Antwerp, Belgium.
C3 Ghent University; Ghent University; University of Antwerp
RP De Smet, S (corresponding author), Univ Ghent, Dept Anim Sci & Aquat Ecol, Lab Anim Nutr & Anim Prod Qual, Coupure Links 653, B-9000 Ghent, Belgium.
EM stefaan.desmet@ugent.be
RI Boon, Nico/B-4083-2011; De Smet, Stefaan/N-7576-2017; de vos,
   winnok/A-6445-2012; De Vrieze, Jo/F-9589-2013
OI Boon, Nico/0000-0002-7734-3103; De Smet, Stefaan/0000-0003-1422-805X;
   Van Hecke, Thomas/0000-0002-6176-6523; de vos,
   winnok/0000-0003-0960-6781; De Vrieze, Jo/0000-0001-9365-8896
FU Special Research Fund (BOF grant) [PDO.2016.0021.01]; Research
   Foundation Flanders (FWO-Vlaanderen)
FX T.V.H. and S.D.S. designed the study. T.V.H., J.D.V. and W.H.D.V.
   performed the experiment and/or analyses. T.V.H., J.D.V., E.V., and N.B.
   analyzed and interpreted the data. T.V.H. wrote the first draft of the
   manuscript and all authors revised the manuscript. This work was
   financially supported by the Special Research Fund (BOF grant
   PDO.2016.0021.01) and benefitted from a statistical consult with Ghent
   University FIRE (Fostering Innovative Research based on Evidence).
   T.V.H., J.D.V. and E.V. were supported as postdoctoral fellows from the
   Research Foundation Flanders (FWO-Vlaanderen). The authors thank S.
   Coolsaet, D. Baeyens, C. Melis, T. Van Der Eecken, and E. Claeys for
   their practical assistance during sampling and laboratory analyses, and
   J. Vermeiren for his practical assistance in the animal facilities.
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NR 60
TC 37
Z9 38
U1 3
U2 28
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1613-4125
EI 1613-4133
J9 MOL NUTR FOOD RES
JI Mol. Nutr. Food Res.
PD JAN
PY 2019
VL 63
IS 2
AR 1800962
DI 10.1002/mnfr.201800962
PG 11
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA HI8KZ
UT WOS:000456706100004
PM 30379400
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Chaudhuri, GR
   Das, A
   Kesh, SB
   Bhattacharya, K
   Dutta, S
   Sengupta, P
   Syamal, AK
AF Chaudhuri, Gargi Ray
   Das, Arnab
   Kesh, Swaraj Bandhu
   Bhattacharya, Koushik
   Dutta, Sulagna
   Sengupta, Pallav
   Syamal, Alak Kumar
TI Obesity and male infertility: multifaceted reproductive disruption
SO MIDDLE EAST FERTILITY SOCIETY JOURNAL
LA English
DT Review
DE Male infertility; Hormones; Obesity; Inflammation; Oxidative stress
ID BODY-MASS INDEX; SPERM DNA FRAGMENTATION; HORMONE-BINDING GLOBULIN;
   PITUITARY-ADRENAL AXIS; NECROSIS-FACTOR-ALPHA; PRADER-WILLI-SYNDROME;
   SEMEN PARAMETERS; ERECTILE DYSFUNCTION; INSULIN-RESISTANCE; METABOLIC
   SYNDROME
AB Background: The global prevalence of obesity has soared to a concerning height in the past few decades. Interestingly, the global decline in semen quality is a parallel occurrence that urges researchers to evaluate if obesity is among the most essential causatives of male infertility or subfertility.
   Main body: Obesity may alter the synchronized working of the reproductive-endocrine milieu, mainly the hypothalamic-pituitary-gonadal (HPG) axis along with its crosstalks with other reproductive hormones. Obesity-mediated impairment in semen parameters may include several intermediate factors, which include physical factors, essentially increased scrotal temperature due to heavy adipose tissue deposits, and systemic inflammation and oxidative stress (OS) initiated by various adipose tissue-derived pro-inflammatory mediators. Obesity, via its multifaceted mechanisms, may modulate sperm genetic and epigenetic conformation, which severely disrupt sperm functions. Paternal obesity reportedly has significant adverse effects upon the outcome of assisted reproductive techniques (ARTs) and the overall health of offspring. Given the complexity of the underlying mechanisms and rapid emergence of new evidence-based hypotheses, the concept of obesity-mediated male infertility needs timely updates and pristine understanding.
   Conclusions: The present review comprehensively explains the possible obesity-mediated mechanisms, especially via physical factors, OS induction, endocrine modulation, immune alterations, and genetic and epigenetic changes, which may culminate in perturbed spermatogenesis, disrupted sperm DNA integrity, compromised sperm functions, and diminished semen quality, leading to impaired male reproductive functions.
C1 [Chaudhuri, Gargi Ray] Nopany Inst Hlth Care Studies, Dept Physiotherapy, Kolkata, W Bengal, India.
   [Das, Arnab] Ramakrishna Miss Vivekanada Educ & Res Inst, Dept Sports Sci & Yoga, Belur Math, Howrah, India.
   [Kesh, Swaraj Bandhu] Govt Med Coll Rajnandgaon, Dept Physiol, Chhattisgarh, Rajnandgaon, India.
   [Bhattacharya, Koushik] Maitri Coll Dent & Res Ctr, Dept Physiol, Durg, Chhattisgarh, India.
   [Dutta, Sulagna] MAHSA Univ, Dept Oral Biol & Biomed Sci, Fac Dent, Jenjarom, Malaysia.
   [Dutta, Sulagna; Sengupta, Pallav] Bharath Inst Higher Educ & Res BIHER, Sch Med Sci, Chennai, Tamil Nadu, India.
   [Sengupta, Pallav] MAHSA Univ, Physiol Unit, Fac Med Biosci & Nursing, Jenjarom, Malaysia.
   [Syamal, Alak Kumar] Univ Burdwan, Post Grad Dept Physiol, Hooghly Mohsin Coll, Burdwan, W Bengal, India.
C3 Mahsa University; Bharath Institute of Higher Education & Research;
   Mahsa University; University of Burdwan
RP Sengupta, P (corresponding author), Bharath Inst Higher Educ & Res BIHER, Sch Med Sci, Chennai, Tamil Nadu, India.; Sengupta, P (corresponding author), MAHSA Univ, Physiol Unit, Fac Med Biosci & Nursing, Jenjarom, Malaysia.
EM pallav_cu@yahoo.com
RI Dutta, Sulagna/W-5151-2017; Das, Arnab/HZL-6235-2023; Sengupta,
   Pallav/E-3392-2016
OI Das, Arnab/0000-0002-3464-4141; Sengupta, Pallav/0000-0002-1928-5048
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NR 180
TC 26
Z9 26
U1 0
U2 11
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1110-5690
EI 2090-3251
J9 MIDDLE EAST FERTIL S
JI Middle East Fertil. Soc. J.
PD APR 4
PY 2022
VL 27
IS 1
AR 8
DI 10.1186/s43043-022-00099-2
PG 12
WC Reproductive Biology
WE Emerging Sources Citation Index (ESCI)
SC Reproductive Biology
GA 0G3YT
UT WOS:000777984800001
OA gold
DA 2025-06-11
ER

PT J
AU Karbownik-Lewinska, M
   Szosland, J
   Kokoszko-Bilska, A
   Stepniak, J
   Zasada, K
   Gesing, A
   Lewinski, A
AF Karbownik-Lewinska, Malgorzata
   Szosland, Janusz
   Kokoszko-Bilska, Agnieszka
   Stepniak, Jan
   Zasada, Krzysztof
   Gesing, Adam
   Lewinski, Andrzej
TI Direct contribution of obesity to oxidative damage to macromolecules
SO NEUROENDOCRINOLOGY LETTERS
LA English
DT Article
DE obesity; oxidative damage; lipid peroxidation; 8-oxo-7,8-dihydro-2
   '-deoxyguanosine; non-communicable diseases
ID INCREASED LIPID-PEROXIDATION; METABOLIC SYNDROME; INSULIN-RESISTANCE;
   DNA-DAMAGE; FENTON REACTION; GROWTH-HORMONE; HIGH-FAT; STRESS; CANCER;
   MELATONIN
AB BACKGROUND: Obesity constitutes a common modifiable risk factor for certain non-communicable diseases (NCDs) associated with enhanced oxidative stress.
   OBJECTIVES AND METHODS: The aim of the study was to examine serum concentrations of malondialdehyde + 4-hydroxyalkenals (MDA+4-HDA), as an index of lipid peroxidation (LPO), and 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) concentration in peripheral blood lymphocytes, as an index of nuclear DNA damage, in overweight and obese adult patients. LPO and 8-oxodG, as well as clinical and laboratory parameters, which are frequently affected by obesity, were evaluated in 58 overweight and obese adult patients, and in 20 healthy volunteers.
   RESULTS: Both LPO and 8-oxodG levels were increased in overweight and obese patients, with further increase observed with the increasing body mass index (BMI). LPO correlated positively with body mass, BMI, waist circumference, hip circumference, waist:hip ratio, systolic or diastolic blood pressure, glucose, C-reactive protein and ferritin concentrations. 8-oxodG correlated positively with body mass, BMI, hip circumference and triglyceride concentration, whereas it correlated negatively with iron concentration. Expectedly, positive correlation between LPO and 8-oxodG was also found.
   CONCLUSIONS: BMI constituted the only independent determinant (predictor) of LPO in overweight and obese patients. Consistently, LPO did constitute the only independent determinant of obesity. Overweight and obesity in adults are directly associated with increased oxidative damage to macromolecules.
C1 [Karbownik-Lewinska, Malgorzata; Szosland, Janusz; Kokoszko-Bilska, Agnieszka; Stepniak, Jan; Zasada, Krzysztof; Gesing, Adam] Med Univ Lodz, Dept Oncol Endocrinol, PL-90752 Lodz, Poland.
   [Lewinski, Andrzej] Med Univ Lodz, Dept Endocrinol & Metab Dis, PL-90752 Lodz, Poland.
   [Karbownik-Lewinska, Malgorzata; Kokoszko-Bilska, Agnieszka; Zasada, Krzysztof; Lewinski, Andrzej] Polish Mothers Mem Hosp, Res Inst, Lodz, Poland.
C3 Medical University Lodz; Medical University Lodz; Polish Mother's
   Memorial Hospital - Research Institute
RP Karbownik-Lewinska, M (corresponding author), Med Univ Lodz, Dept Oncol Endocrinol, 7-9 Zeligowski St, PL-90752 Lodz, Poland.
EM MKarbownik@hotmail.com
RI Stepniak, Jan/AAF-3230-2020; Kokoszko-Bilska, Agnieszka/O-2307-2014;
   Lewinski, Andrzej/N-3971-2014; Gesing, Adam/S-4509-2016; Lewinski,
   Andrzej/S-9985-2016; Karbownik-Lewinska, Malgorzata/S-9169-2016
OI Gesing, Adam/0000-0003-4276-057X; Stepniak, Jan/0000-0002-7547-6228;
   Lewinski, Andrzej/0000-0002-8748-3337; Karbownik-Lewinska,
   Malgorzata/0000-0002-3045-5669
FU Medical University of Lodz [503-1107-5]
FX The research was supported by the Medical University of Lodz (grant
   number 503-1107-5).
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NR 39
TC 30
Z9 32
U1 1
U2 9
PU MAGHIRA & MAAS PUBLICATIONS
PI STOCKHOLM
PA PO BOX 26132, S-100 41 STOCKHOLM, SWEDEN
SN 0172-780X
J9 NEUROENDOCRINOL LETT
JI Neuroendocrinol. Lett.
PY 2012
VL 33
IS 4
BP 453
EP 461
PG 9
WC Endocrinology & Metabolism; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology
GA 026FH
UT WOS:000310259500016
PM 22936256
DA 2025-06-11
ER

PT J
AU Calmasini, FB
   Silva, FH
   Alexandre, EC
   Antunes, E
AF Calmasini, F. B.
   Silva, F. H.
   Alexandre, E. C.
   Antunes, E.
TI Efficacy of resveratrol in male urogenital tract dysfunctions: an
   evaluation of pre-clinical data
SO NUTRITION RESEARCH REVIEWS
LA English
DT Review
DE Prostatic diseases; Lower urinary tract; Erectile dysfunction;
   Polyphenol
ID BENIGN PROSTATIC HYPERPLASIA; TRANS-RESVERATROL; OXIDATIVE STRESS;
   SMOOTH-MUSCLE; DOWN-REGULATION; ERECTILE DYSFUNCTION; URINARY
   DYSFUNCTION; METABOLIC SYNDROME; CORPUS CAVERNOSUM; PEANUT SPROUT
AB Resveratrol is a polyphenol found naturally in fruits and plants. Recently, studies in humans and animal models have suggested beneficial properties of this polyphenol, such as improvements to metabolic and lipid profiles, along with antioxidant, anti-inflammatory and anti-proliferative effects. In the urogenital tract (UGT), resveratrol has also been tested clinically and experimentally as a therapeutic drug in several diseases; however, the translational efficacy of resveratrol, especially in UGT, is still a matter of debate. In the present review, we address the pre-clinical efficacy of resveratrol in UGT-related dysfunctions, focusing on lower urinary tract symptoms, non-cancerous prostatic disease (benign prostatic hyperplasia and prostatitis) and erectile dysfunction. In vitro studies indicate that resveratrol reduces inflammatory markers and oxidative stress, and improves endothelial function in UGT organs and cells isolated from humans and animals. Despite displaying low oral bioavailability, in vivo administration of resveratrol largely improves erectile dysfunction, benign prostatic hyperplasia, prostatitis and voiding impairments, as evidenced in different animal models. Resveratrol also acts as a microbiota modulator, which may explain some of its beneficial effects in vivo. In contrast to the large amount of pre-clinical data, there are insufficient clinical trials to establish resveratrol treatment efficacy in human UGT-related diseases. In summary, we provide an overview of the in vivo and in vitro efficacy of resveratrol in animal and human UGT dysfunctions, which may support future clinical trials.
C1 [Calmasini, F. B.] Univ Campinas UNICAMP, Dept Struct & Funct Biol, Campinas, SP, Brazil.
   [Silva, F. H.] Sao Francisco Univ USF, Lab Multidisciplinary Res, Braganca Paulista, SP, Brazil.
   [Alexandre, E. C.; Antunes, E.] Univ Campinas UNICAMP, Fac Med Sci, Dept Pharmacol, Campinas, SP, Brazil.
C3 Universidade Estadual de Campinas; Universidade Sao Francisco;
   Universidade Estadual de Campinas
RP Calmasini, FB (corresponding author), Univ Campinas UNICAMP, Dept Struct & Funct Biol, Campinas, SP, Brazil.
EM fabiano.b.calmasini@gmail.com
RI Alexandre, Eduardo/D-3797-2013; Calmasini, Fabiano/S-9691-2019; SILVA,
   FABIO/AAZ-8140-2020; Silva, Fabio/D-5412-2013
OI Silva, Fabio/0000-0003-3374-5570; Beraldi Calmasini,
   Fabiano/0000-0002-7790-2550
FU Sao Paulo Research Foundation (FAPESP) [2019/09912-9, 2020/06254-8]
FX This work was supported by the Sao Paulo Research Foundation (FAPESP;
   grant numbers 2019/09912-9 and 2020/06254-8). FAPESP had no role in the
   design, analysis orwriting of this article.
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NR 104
TC 4
Z9 4
U1 0
U2 8
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0954-4224
EI 1475-2700
J9 NUTR RES REV
JI Nutr. Res. Rev.
PD JUN
PY 2023
VL 36
IS 1
BP 86
EP 97
AR S0954422421000354
DI 10.1017/S0954422421000354
EA NOV 2021
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA F9MB0
UT WOS:000777860000001
PM 34776039
OA Bronze
DA 2025-06-11
ER

PT J
AU He, Q
   Zhang, TQ
   Jin, B
   Wu, YH
   Wu, JM
   Gao, P
   Wu, SW
AF He, Qi
   Zhang, Tianqing
   Jin, Bing
   Wu, Yonghe
   Wu, Jiamin
   Gao, Pu
   Wu, Shiwei
TI Exploring the Regulatory Mechanism of Modified Huanglian Maidong
   Decoction on Type 2 Diabetes Mellitus Biological Network Based on
   Systematic Pharmacology
SO EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Article
ID TRADITIONAL CHINESE MEDICINE; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   COPTIDIS-RHIZOMA; OLIGOSACCHARIDES; PATHOPHYSIOLOGY; POLYSACCHARIDE;
   OPHIOPOGONIS; JAPONICUS; STRESS
AB Objective. To explore the mechanism of modified Huanglian Maidong decoction (Maidong-Sanqi-Huanglian Compounds, MSHCs) intervention in type 2 diabetes mellitus (T2DM). Method. This study used PubChem and SciFinder to collect the molecular structure of MSHCs, used PharmMapper to predict the potential targets of MSHC, and combined them with the T2DM gene to construct MSHC-T2DM protein-protein interaction (PPI) network. The plugin MCODE in Cytoscape 3.7.1 was then used to perform cluster analysis on the MSHC-T2DM PPI network. The genes and targets were input into DAVID for Gene Ontology (GO) and pathway enrichment analysis. Finally, animal experiments were performed to verify the therapeutic effect of MSHC on T2DM. Results. Several T2DM-related targets, clusters, signaling pathways, and biological processes are found. The experimental results showed that compared with the blank group, the content of fasting blood glucose (FBG) in the model group was higher (P<0.01). Compared with the model group, the content of FBG decreased and the insulin level increased in the MSHC medium-dose (0.15 g/kg) and high-dose (0.45 g/kg) groups and metformin group after 4 weeks of drug administration (P<0.05). MSHC can also improve blood liquid levels and inflammatory factor levels (P<0.05). Conclusion. MSHC may achieve therapeutic effects through regulating the T2DM-related targets, biological processes, and pathways, such as insulin resistance, energy metabolism, oxidative stress, and inflammation, found in this research.
C1 [He, Qi] Peoples Hosp Ningxiang City, Ningxiang, Hunan, Peoples R China.
   [Zhang, Tianqing; Wu, Yonghe; Wu, Jiamin] Univ South China, Grad Coll, Hengyang, Hunan, Peoples R China.
   [Jin, Bing; Gao, Pu] China Acad Chinese Med Sci, Xiyuan Hosp, Beijing, Peoples R China.
   [Wu, Shiwei] Sun Yat Sen Univ, Affiliated Hosp 8, Dept Tradit Chinese Med, Shenzhen, Guangdong, Peoples R China.
C3 University of South China; Xiyuan Hospital, CACMS; China Academy of
   Chinese Medical Sciences; Sun Yat Sen University
RP Wu, SW (corresponding author), Sun Yat Sen Univ, Affiliated Hosp 8, Dept Tradit Chinese Med, Shenzhen, Guangdong, Peoples R China.
EM heqi.ningxiang@outlook.com; 892821194@qq.com; lordnec@126.com;
   923489595@qq.com; 769520635@qq.com; xiyuangp321@163.com;
   zhongyiyao321@163.com
OI He, Qi/0000-0002-3243-8002; He, Qi/0000-0002-5416-5623
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NR 52
TC 3
Z9 4
U1 2
U2 30
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1741-427X
EI 1741-4288
J9 EVID-BASED COMPL ALT
JI Evid.-based Complement Altern. Med.
PD JUL 13
PY 2021
VL 2021
AR 1768720
DI 10.1155/2021/1768720
PG 13
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA TT7JP
UT WOS:000680521200006
PM 34335798
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Kimura, H
   Ota, H
   Kimura, Y
   Takasawa, S
AF Kimura, Hiroshi
   Ota, Hiroyo
   Kimura, Yuya
   Takasawa, Shin
TI Effects of Intermittent Hypoxia on Pulmonary Vascular and Systemic
   Diseases
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Review
DE sleep apnea; intermittent hypoxia; sympathetic nerve; pulmonary
   hypertension; REM sleep; lifestyle-related diseases; insulin secretion;
   insulin resistance
ID OBSTRUCTIVE SLEEP-APNEA; INDUCED INSULIN-SECRETION; ADP-RIBOSE
   HYDROLASE; METABOLIC SYNDROME; REGENERATION FACTOR; OXIDATIVE STRESS;
   UP-REGULATION; GENE; REG; AUTOANTIBODIES
AB Obstructive sleep apnea (OSA) causes many systemic disorders via mechanisms related to sympathetic nerve activation, systemic inflammation, and oxidative stress. OSA typically shows repeated sleep apnea followed by hyperventilation, which results in intermittent hypoxia (IH). IH is associated with an increase in sympathetic activity, which is a well-known pathophysiological mechanism in hypertension and insulin resistance. In this review, we show the basic and clinical significance of IH from the viewpoint of not only systemic regulatory mechanisms focusing on pulmonary circulation, but also cellular mechanisms causing lifestyle-related diseases. First, we demonstrate how IH influences pulmonary circulation to cause pulmonary hypertension during sleep in association with sleep state-specific change in OSA. We also clarify how nocturnal IH activates circulating monocytes to accelerate the infiltration ability to vascular wall in OSA. Finally, the effects of IH on insulin secretion and insulin resistance are elucidated by using an in vitro chamber system that can mimic and manipulate IH. The obtained data implies that glucose-induced insulin secretion (GIS) in pancreatic beta cells is significantly attenuated by IH, and that IH increases selenoprotein P, which is one of the hepatokines, as well as TNF-alpha, CCL-2, and resistin, members of adipokines, to induce insulin resistance via direct cellular mechanisms. Clinical and experimental findings concerning IH give us productive new knowledge of how lifestyle-related diseases and pulmonary hypertension develop during sleep.
C1 [Kimura, Hiroshi] Nippon Med Sch, Grad Sch Med, Dept Adv Med Pulm Circulat & Resp Failure, Bunkyo Ku, Tokyo 1138603, Japan.
   [Ota, Hiroyo] Nara Med Univ, Dept Resp Med, Kashihara, Nara 6348522, Japan.
   [Kimura, Yuya] NHO Tokyo Natl Hosp, Ctr Pulm Dis, Tokyo 2040023, Japan.
   [Takasawa, Shin] Nara Med Univ, Dept Biochem, Kashihara, Nara 6348521, Japan.
C3 Nippon Medical School; Nara Medical University; Nara Medical University
RP Kimura, H (corresponding author), Nippon Med Sch, Grad Sch Med, Dept Adv Med Pulm Circulat & Resp Failure, Bunkyo Ku, Tokyo 1138603, Japan.
EM kimura@naramed-u.ac.jp
RI Kimura, Hiroshi/AGU-7339-2022; Kimura, Yuya/KYP-1829-2024
OI Kimura, Yuya/0000-0003-1649-0596; Takasawa, Shin/0000-0002-4066-0199
FU Actelion Pharmaceuticals Japan
FX H. Kimura works in the Department of Advanced Medicine for Pulmonary
   Circulation and Respiratory Failure, Nippon Medical School Graduate
   School of Medicine, which is an endowment department, supported with an
   unrestricted grant to Nippon Medical School from Actelion
   Pharmaceuticals Japan. This research received no external funding.
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NR 74
TC 33
Z9 36
U1 0
U2 7
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-7827
EI 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD SEP 1
PY 2019
VL 16
IS 17
AR 3101
DI 10.3390/ijerph16173101
PG 13
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA IZ4EQ
UT WOS:000487037500096
PM 31455007
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Barbosa, KBF
   Volp, ACP
   Marques-Rocha, JL
   Ribeiro, SMR
   Navarro-Blasco, I
   Zulet, MA
   Martínez, JA
   Bressan, J
AF Ferreira Barbosa, Kiriaque Barra
   Pinheiro Volp, Ana Carolina
   Marques-Rocha, Jose Luiz
   Rocha Ribeiro, Sonia Machado
   Navarro-Blasco, Inigo
   Angeles Zulet, Maria
   Alfredo Martinez, J.
   Bressan, Josefina
TI Modulators of erythrocyte glutathione peroxidase activity in healthy
   adults: An observational study
SO REDOX REPORT
LA English
DT Article
DE Erythrocyte GPx activity; Oxidative stress; Antioxidant capacity;
   Dietary intake; Biomarkers; Antioxidant assessment
ID OXIDATIVE STRESS MARKERS; SUPEROXIDE-DISMUTASE; ANTIOXIDANT STATUS;
   METABOLIC SYNDROME; VITAMIN-C; SELENIUM SUPPLEMENTATION;
   LIPID-PEROXIDATION; YOUNG ADULTS; IN-VIVO; SERUM
AB The aim of this study was to investigate the potential modulators of erythrocyte glutathione peroxidase (GPx) activity in young and apparently healthy individuals. One hundred one individuals (53 women and 48 men) were evaluated for anthropometric measurements, biochemical markers, clinical, dietary, and endogenous and exogenous components of the antioxidant defense system. Statistical analysis was performed to detect differences among subjects by the median of GPx activity. A linear regression model and Spearman correlation coefficients were used to screen the associations between GPx activity and interest variables. Individuals with higher GPx enzymatic activity were older and higher circulating levels of oxidized low-density lipoprotein (ox-LDL) values, but conversely lower nail concentrations of selenium and copper (P<0.05). The GPx activity was positively correlated to truncal fat percentage values (r = 0.24, P = 0.016), circulating levels of ox-LDL (r = 0.28, P = 0.004), and daily vitamin C intake (r = 0.28, P = 0.007), and negatively correlated to the nail concentration of selenium (r = -0.24, P = 0.026). Interesting, it was noticed that the truncal fat percentage and circulating levels of ox-LDL explained 5.9 and 7.4% of the GPx enzymatic activity. Thus, preventive measures such as adequate antioxidant intake and proper fat percentage would be a priority in the nutritional care of young and apparently healthy individuals.
C1 [Ferreira Barbosa, Kiriaque Barra] Univ Fed Sergipe, Nutr Ctr, Aracaju, Brazil.
   [Pinheiro Volp, Ana Carolina] Univ Fed Ouro Preto, Dept Social Clin & Nutr, Ouro Preto, Brazil.
   [Marques-Rocha, Jose Luiz; Rocha Ribeiro, Sonia Machado; Bressan, Josefina] Univ Fed Vicosa, Dept Nutr & Hlth, Vicosa, MG, Brazil.
   [Navarro-Blasco, Inigo] Univ Navarra, Dept Chem & Soil Sci, E-31080 Pamplona, Spain.
   [Marques-Rocha, Jose Luiz; Angeles Zulet, Maria; Alfredo Martinez, J.] Univ Navarra, Ctr Nutr Res, Dept Nutr Food Sci & Physiol, E-31080 Pamplona, Spain.
   [Angeles Zulet, Maria; Alfredo Martinez, J.] Carlos III Inst, CIBERobn, Madrid, Spain.
C3 Universidade Federal de Sergipe; Universidade Federal de Ouro Preto;
   Universidade Federal de Vicosa; University of Navarra; University of
   Navarra; CIBER - Centro de Investigacion Biomedica en Red; CIBEROBN
RP Martínez, JA (corresponding author), Univ Navarra, Dept Nutr Food Sci & Physiol, C Irunlarrea 1, Navarra 31008, Spain.
EM jalfmtz@unav.es
RI Bressan, Josefina/A-2598-2009; Barbosa, Kiriaque/E-4269-2014; Zulet, M.
   Angeles/H-1317-2017; Martinez Hernandez, J Alfredo/K-8709-2014;
   Navarro-Blasco, Inigo/D-8148-2012
OI Zulet, M. Angeles/0000-0002-3926-0892; Martinez Hernandez, J
   Alfredo/0000-0001-5218-6941; Marques-Rocha, Jose
   Luiz/0000-0002-0783-5807; Navarro-Blasco, Inigo/0000-0003-1863-0580;
   Bressan, Josefina/0000-0002-4993-9436
FU Fundacao de Amparo a Pesquisa do Estado de Minas Gerais [FAPEMIG CDS
   303/06]; Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior
   (CAPES)
FX This study was supported by the Fundacao de Amparo a Pesquisa do Estado
   de Minas Gerais (FAPEMIG CDS 303/06) and the Coordenacao de
   Aperfeicoamento de Pessoal de Nivel Superior (CAPES). We acknowledge
   D.S., Sergio O. de Paula, D.S., Leandro L. de Oliveira, D.S., Antonio
   Policarpo S. Carneiro, and D.S. Neuza M.B. Costa for technical
   assistance, Shauna Drumm, for language review and Elisangela Lessa,
   Damiana D. Rosa and Carolina O. Resende for helping with data
   collection. We also thank all volunteers for their participation in the
   study.
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NR 42
TC 3
Z9 4
U1 0
U2 5
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1351-0002
EI 1743-2928
J9 REDOX REP
JI Redox Rep.
PD NOV
PY 2014
VL 19
IS 6
BP 251
EP 258
DI 10.1179/1351000214Y.0000000098
PG 8
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA AR0DW
UT WOS:000343238300004
PM 24949651
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Garcia, JJ
   Martin-Cordero, L
   Hinchado, MD
   Bote, ME
   Ortega, E
AF Garcia, J. J.
   Martin-Cordero, L.
   Hinchado, M. D.
   Bote, M. E.
   Ortega, E.
TI Effects of Habitual Exercise on the eHsp72-Induced Release of
   Inflammatory Cytokines by Macrophages from Obese Zucker Rats
SO INTERNATIONAL JOURNAL OF SPORTS MEDICINE
LA English
DT Article
DE obesity; inflammation; IL-1 beta; IL-6; TNF alpha; Zucker rats
ID HEAT-SHOCK PROTEINS; EXTRACELLULAR HSP72; CANDIDA-ALBICANS;
   IMMUNE-RESPONSE; DANGER SIGNAL; STRESS; INTENSITY; CORTICOSTERONE;
   PHAGOCYTOSIS; ANTIOXIDANT
AB Regular exercise is a good non-pharmacological treatment of metabolic syndrome in that it improves obesity, diabetes, and inflammation. The 72 kDa extracellular heat shock protein (eHsp72) is released during exercise, thus stimulating the inflammatory responses. The aim of the present work was to evaluate the effect of regular exercise on the eHsp72-induced release of IL-1 beta, IL-6, and TNF alpha by macrophages from genetically obese Zucker rats (fa/fa) (ObZ), using lean Zucker (LZ) rats (Fa/fa) to provide reference values. ObZ presented a higher plasma concentration of eHsp72 than LZ, and exercise increased that concentration. In response to eHsp72, the macrophages from ObZ released less IL-1 beta and TNF alpha, but more IL-6, than macrophages from LZ. While eHsp72 stimulated the release of IL-1 beta, TNF alpha, and IL-6 in the macrophages from healthy LZ (with respect to the constitutive release), it inhibited the release of IL-1 beta and IL-6 in macrophages from ObZ. The habitual exercise improved the release of inflammatory cytokines by macrophages from ObZ in response to eHsp72 (it increased IL-1 beta and TNF alpha, and decreased IL-6), tending to values closer to those determined in healthy LZ. A deregulated macrophage inflammatory and stress response induced by eHsp72 underlies MS, and this is improved by habitual exercise.
C1 [Garcia, J. J.; Martin-Cordero, L.; Hinchado, M. D.; Bote, M. E.; Ortega, E.] Univ Extremadura, E-06071 Badajoz, Spain.
C3 Universidad de Extremadura
RP Ortega, E (corresponding author), Univ Extremadura, Fac Ciencias, Avda Elvas S-N, E-06071 Badajoz, Spain.
EM orincon@unex.es
RI ; Ortega, Eduardo/H-9891-2016; Martin-Cordero, Leticia/H-9711-2015;
   Garcia, Juan/C-7383-2013
OI Bote, Maria Elena/0000-0002-3112-9259; HINCHADO SANCHEZ-MORO, MARIA
   DOLORES/0000-0002-9709-4714; Ortega, Eduardo/0000-0002-7007-7615;
   Martin-Cordero, Leticia/0000-0002-3651-2265; Garcia,
   Juan/0000-0002-8222-4213
FU MICIN-FEDER [DEP2006 56187]; Junta de Extremadura-FEDER, Spain [GR10020]
FX This work was supported by MICIN-FEDER (DEP2006 56187) and Junta de
   Extremadura-FEDER (GR10020), Spain. We are grateful for the
   collaboration of specialized personnel of the animal facilities at the
   Faculty of Medicine of the Autonomous University of Madrid.
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NR 52
TC 12
Z9 12
U1 0
U2 7
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0172-4622
EI 1439-3964
J9 INT J SPORTS MED
JI Int. J. Sports Med.
PD JUN
PY 2013
VL 34
IS 6
BP 559
EP 564
DI 10.1055/s-0032-1327650
PG 6
WC Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Sport Sciences
GA 174FO
UT WOS:000321140100015
PM 23180211
DA 2025-06-11
ER

PT J
AU Standl, E
   Schnell, O
AF Standl, Eberhard
   Schnell, Oliver
TI Increased Risk of Cancer-An Integral Component of the
   Cardio-Renal-Metabolic Disease Cluster and Its Management
SO CELLS
LA English
DT Article
DE cancer; hyperinsulinemia; insulin resistance; oxidative stress;
   low-grade inflammation; diabetes; cardio-renal-metabolic syndrome
ID CARDIOVASCULAR-DISEASE; OUTCOMES; MORTALITY; INSIGHTS; INSULIN; TYPE-1
AB Cancer risk increases by 25 to 250% not only in dysmetabolic obese or overweight people with overt type 2 diabetes but also in individuals with intermediate hyperglycemia (pre-diabetes), with especially pronounced risk of pancreatic or hepatocellular cancer and obesity-related cancers, e.g., colorectal and kidney cancers, bladder cancer in men, and endometrial and breast cancers in women. Cancer may often be present before or upon the diagnosis of diabetes, as there is a common pathogenetic dysmetabolic-inflammatory background with insulin resistance for developing diabetes, cardiorenal disease, and cancer in parallel. The mechanisms involved relate to hyperinsulinemia as a potential carcinogenic priming event with ectopic visceral, hepatic, pancreatic, or renal fat accumulation that subsequently fuel inflammation and lipo-oncogenic signals, causing mitochondrial oxidative stress and deregulation. Moreover, hyperinsulinemia may foster mitogenic MAP kinase-related signaling, which can also occur via IGF1 receptors due to increased free IGF1 levels in obesity. Weight reduction of 10% or more in obese people with diabetes or pre-diabetes, e.g., through intensive lifestyle intervention or bariatric (=metabolic) surgery or through treatment with GLP-1 receptor agonists or metformin, is associated with significantly lower incidence of "diabesity"-associated cancers. In conclusion, there seems to be huge utility in adopting the new "Cardio-Renal-Metabolic-Cancer Syndrome" approach, also looking for cancer at the time of diabetes diagnosis in addition to proactively screening for undiagnosed dysglycemia.
C1 [Standl, Eberhard; Schnell, Oliver] Helmholtz Ctr Munich, Forschergruppe Diabet e V, Ingolstaedter Landstr 1, D-85764 Munich, Germany.
C3 Helmholtz Association; Helmholtz-Center Munich - German Research Center
   for Environmental Health
RP Standl, E (corresponding author), Helmholtz Ctr Munich, Forschergruppe Diabet e V, Ingolstaedter Landstr 1, D-85764 Munich, Germany.
EM eberhard.standl@lrz.uni-muenchen.de
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NR 66
TC 0
Z9 0
U1 0
U2 0
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2073-4409
J9 CELLS-BASEL
JI Cells
PD APR 9
PY 2025
VL 14
IS 8
AR 564
DI 10.3390/cells14080564
PG 13
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA 1VD6P
UT WOS:001474402500001
PM 40277890
DA 2025-06-11
ER

PT J
AU Garza-Campos, A
   Prieto-Correa, JR
   Domínguez-Rosales, JA
   Hernández-Nazará, ZH
AF Garza-Campos, Andrea
   Prieto-Correa, Jose Roberto
   Dominguez-Rosales, Jose Alfredo
   Hernandez-Nazara, Zamira Helena
TI Implications of receptor for advanced glycation end products for
   progression from obesity to diabetes and from diabetes to cancer
SO WORLD JOURNAL OF DIABETES
LA English
DT Review
DE Type 2 diabetes; Cancer; Obesity; Advanced glycation end product
   receptor; Receptor for advanced glycation end products; Glycation end
   products; advanced
ID FATTY LIVER-DISEASE; SOLUBLE RECEPTOR; METABOLIC SYNDROME; SERUM-LEVELS;
   RAGE; EXPRESSION; AUTOPHAGY; MARKERS; FOOD; AGE
AB Obesity and type 2 diabetes mellitus (T2DM) are chronic pathologies with a high incidence worldwide. They share some pathological mechanisms, including hyperinsulinemia, the production and release of hormones, and hyperglycemia. The above, over time, affects other systems of the human body by causing tissue hypoxia, low-grade inflammation, and oxidative stress, which lay the pathophysiological groundwork for cancer. The leading causes of death globally are T2DM and cancer. Other main alterations of this pathological triad include the accumulation of advanced glycation end products and the release of endogenous alarmins due to cell death (i.e., damage-associated molecular patterns) such as the intracellular proteins high-mobility group box protein 1 and protein S100 that bind to the receptor for advanced glycation products (RAGE) - a multiligand receptor involved in inflammatory and metabolic and neoplastic processes. This review analyzes the latest advanced reports on the role of RAGE in the development of obesity, T2DM, and cancer, with an aim to understand the intracellular signaling mechanisms linked with cancer initiation. This review also explores inflammation, oxidative stress, hypoxia, cellular senescence, RAGE ligands, tumor microenvironment changes, and the "cancer hallmarks" of the leading tumors associated with T2DM. The assimilation of this information could aid in the development of diagnostic and therapeutic approaches to lower the morbidity and mortality associated with these diseases.
C1 [Garza-Campos, Andrea; Prieto-Correa, Jose Roberto] Univ Guadalajara, Programa Ciencias Biol Mol Med, Guadalajara 44340, Jalisco, Mexico.
   [Garza-Campos, Andrea; Prieto-Correa, Jose Roberto; Dominguez-Rosales, Jose Alfredo; Hernandez-Nazara, Zamira Helena] Univ Guadalajara, Dept Biol Mol & Genom, Inst Invest Enfermedades Cron Degenerat, Guadalajara 44340, Jalisco, Mexico.
   [Hernandez-Nazara, Zamira Helena] Univ Guadalajara, Dept Biol Mol & Genom, Inst Invest Enfermedades Cron Degenerat, Sierra Mojada 950, Guadalajara 44340, Jalisco, Mexico.
C3 Universidad de Guadalajara; Universidad de Guadalajara; Universidad de
   Guadalajara
RP Hernández-Nazará, ZH (corresponding author), Univ Guadalajara, Dept Biol Mol & Genom, Inst Invest Enfermedades Cron Degenerat, Sierra Mojada 950, Guadalajara 44340, Jalisco, Mexico.
EM zamirahelena@yahoo.com.mx
RI Hernandez Nazara, Zamira Helena/KCY-5114-2024
FU Proyectos de Impulso a la Investigacion to Hernandez-Nazara ZH from
   Universidad de Guadalajara, Mexico [PIN 2020-I]
FX Supported by the Founding Proyectos de Impulso a la Investigacion to
   Hernandez-Nazara ZH from Universidad de Guadalajara, Mexico, No. PIN
   2020-I.
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NR 169
TC 9
Z9 9
U1 7
U2 30
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 7041 Koll Center Parkway, Suite 160, PLEASANTON, CA, UNITED STATES
EI 1948-9358
J9 WORLD J DIABETES
JI World J. Diabetes
PD JUL 15
PY 2023
VL 14
IS 7
BP 977
EP 994
DI 10.4239/wjd.v14.i7.977
PG 18
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA O5UV9
UT WOS:001044467500004
PM 37547586
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Oh, SJ
   Lee, MS
AF Oh, Soo-Jin
   Lee, Myung-Shik
TI Role of Autophagy in the Pathogenesis of Diabetes and Therapeutic
   Potential of Autophagy Modulators in the Treatment of Diabetes and
   Metabolic Syndrome
SO JOURNAL OF KOREAN MEDICAL SCIENCE
LA English
DT Review
DE Autophagy; ER; Mitochondria; Metabolic Inflammation; Islet Amyloid; IAPP
ID ISLET AMYLOID POLYPEPTIDE; ENDOPLASMIC-RETICULUM STRESS; PANCREATIC
   BETA-CELLS; TRANSGENIC MICE; INSULIN-RESISTANCE; HUMAN IAPP; RAT-LIVER;
   IDENTIFICATION; ACTIVATION; OBESITY
AB Autophagy is critically involved in the maintenance of intracellular nutrient homeostasis and organelle function. Dysregulated autophagy is likely to play a role in the development of metabolic disorders and diabetes because autophagy is critical in the rejuvenation of dysfunctional or stressed endoplasmic reticulum and mitochondria that play a crucial role in the development of diabetes. Indeed, systemic autophagy insufficiency led to the increased tissue lipid content, aggravated metabolic and finally more severe diabetes when metabolic stress was imposed, suggesting that autophagy insufficiency of dysfunction of lysosome, an effector organelle of autophagy, due to aging, genetic predisposition or environmental factors could be an underlying cause of diabetes. Conversely, autophagy enhancer could improve metabolic profile of obese mice by reducing tissue lipid content and ameliorating metabolic inflammation. Furthermore, clearance of human islet amyloid polypeptide (hIAPP) oligomer and amyloid that accumulate in pancreatic islets of > 90% of diabetes patients was also dependent on autophagy. Consistently, autophagy enhancer could improve glucose profile and beta-cell function of transgenic mice expressing amyloidogenic hIAPP in pancreatic beta-cells, which was accompanied by reduced accumulation of hIAPP oligomer or amyloid, ameliorated beta-cell apoptosis and increased beta-cell mass. These results suggest that autophagy enhancer could be a novel therapeutic modality against diabetes associated with lipid overload and human diabetes characterized by islet amyloid accumulation.
C1 [Oh, Soo-Jin; Lee, Myung-Shik] Soonchunhyang Univ, Soonchunhyang Inst Medibio Sci, Coll Med, Cheonan, South Korea.
   [Oh, Soo-Jin; Lee, Myung-Shik] Soonchunhyang Univ, Dept Internal Med, Div Endocrinol, Coll Med, Cheonan, South Korea.
   [Lee, Myung-Shik] Soonchunhyang Inst Medibio Sci, 25 Bondjung Ro, Cheonan 31151, South Korea.
C3 Soonchunhyang University; Soonchunhyang University; Soonchunhyang
   University
RP Lee, MS (corresponding author), Soonchunhyang Inst Medibio Sci, 25 Bondjung Ro, Cheonan 31151, South Korea.
EM mslee0923@sch.ac.kr
RI Lee, Myung/C-9606-2011
OI Lee, Myung-Shik/0000-0003-3292-1720; Oh, Soo-Jin/0000-0001-9267-2039
FU National Research Foundation of Korea (NRF) - Korea government (MSIT)
   [NRF-2019R1A2C3002924]; Bio&Medical Technology Development Program
   [2017M3A9G7073521]; Korea Drug Development Fund from the Ministry of
   Science & ICT, Ministry of Trade, Industry & Energy and Ministry of
   Health Welfare [HN22C0278]; Faculty Research Assistance Program of
   Soonchunhyang University [20220346]
FX This study was supported by a National Research Foundation of Korea
   (NRF) grant funded by the Korea government (MSIT) (NRF-2019R1A2C3002924)
   and by the Bio&Medical Technology Development Program
   (2017M3A9G7073521). M-S Lee is the recipient of Korea Drug Development
   Fund from the Ministry of Science & ICT, Ministry of Trade, Industry &
   Energy and Ministry of Health & Welfare (HN22C0278), and a grant from
   the Faculty Research Assistance Program of Soonchunhyang University
   (20220346).
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NR 76
TC 8
Z9 8
U1 2
U2 22
PU KOREAN ACAD MEDICAL SCIENCES
PI SEOUL
PA 4F, 37 Ichon-ro 46-Gil, Yongsan-gu, SEOUL, SOUTH KOREA
SN 1011-8934
EI 1598-6357
J9 J KOREAN MED SCI
JI J. Korean Med. Sci.
PD SEP 26
PY 2022
VL 37
IS 37
AR e276
DI 10.3346/jkms.2022.37.e276
PG 17
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 5C7WF
UT WOS:000864465400003
PM 36163475
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Soto, ME
   Guarner-Lans, V
   Díaz-Díaz, E
   Manzano-Pech, L
   Palacios-Chavarría, A
   Valdez-Vázquez, RR
   Aisa-Alvarez, A
   Saucedo-Orozco, H
   Pérez-Torres, I
AF Elena Soto, Maria
   Guarner-Lans, Veronica
   Diaz-Diaz, Eulises
   Manzano-Pech, Linaloe
   Palacios-Chavarria, Adrian
   Valdez-Vazquez, Rafael Ricardo
   Aisa-Alvarez, Alfredo
   Saucedo-Orozco, Huitzilihuitl
   Perez-Torres, Israel
TI Hyperglycemia and Loss of Redox Homeostasis in COVID-19 Patients
SO CELLS
LA English
DT Article
DE SARS-CoV-2; homeostasis redox; hyperglycemia; lipid peroxidation;
   selenium; thiols; nitrotyrosine; H2S
ID HEPATITIS-C VIRUS; INSULIN-RESISTANCE; OXIDATIVE STRESS; SARS-COV-2
   INFECTION; BETA-CELLS; GLUCOSE; ASSOCIATION; DISEASE; MARKER
AB The infection with SARS-CoV-2 impairs the glucose-insulin axis and this contributes to oxidative (OS) and nitrosative (NSS) stress. Here, we evaluated changes in glucose metabolism that could promote the loss of redox homeostasis in COVID-19 patients. This was comparative cohort and analytical study that compared COVID-19 patients and healthy subjects. The study population consisted of 61 COVID-19 patients with and without comorbidities and 25 healthy subjects (HS). In all subjects the plasma glucose, insulin, 8-isoprostane, Vitamin D, H2S and 3-nitrotyrosine were determined by ELISA. The nitrites (NO2-), lipid-peroxidation (LPO), total-antioxidant-capacity (TAC), thiols, glutathione (GSH) and selenium (Se) were determined by spectrophotometry. The glucose, insulin and HOMA-IR (p < 0.001), 8-isoprostanes, 3-nitrotyrosine (p < 0.001) and LPO were increased (p = 0.02) while Vitamin D (p = 0.01), H2S, thiols, TAC, GSH and Se (p < 0.001) decreased in COVID-19 patients in comparison to HS. The SARS-CoV-2 infection resulted in alterations in the glucose-insulin axis that led to hyperglycemia, hyperinsulinemia and IR in patients with and without comorbidities. These alterations increase OS and NSS reflected in increases or decreases in some oxidative markers in plasma with major impact or fatal consequences in patients that course with metabolic syndrome. Moreover, subjects without comorbidities could have long-term alterations in the redox homeostasis after infection.
C1 [Elena Soto, Maria; Aisa-Alvarez, Alfredo; Saucedo-Orozco, Huitzilihuitl] Inst Nacl Cardiol Ignacio Chavez, Dept Immunol, Juan Badiano 1,Secc 16, Mexico City 14080, DF, Mexico.
   [Guarner-Lans, Veronica] Inst Nacl Cardiol Ignacio Chavez, Dept Physiol, Juan Badiano 1,Secc 16, Mexico City 14080, DF, Mexico.
   [Diaz-Diaz, Eulises] Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Reprod Biol, Vasco de Quiroga 15,Secc 16, Mexico City 14000, DF, Mexico.
   [Manzano-Pech, Linaloe; Perez-Torres, Israel] Inst Nacl Cardiol Ignacio Chavez, Dept Cardiovasc Biomed, Mexico City 14080, DF, Mexico.
   [Palacios-Chavarria, Adrian; Valdez-Vazquez, Rafael Ricardo] Citibanamex Ctr, Crit Care Unit, Temporal COVID 19 Unit, Mexico City 11200, DF, Mexico.
C3 National Institute of Cardiology - Mexico; National Institute of
   Cardiology - Mexico; Instituto Nacional de Ciencias Medicas y Nutricion
   Salvador Zubiran - Mexico; National Institute of Cardiology - Mexico
RP Pérez-Torres, I (corresponding author), Inst Nacl Cardiol Ignacio Chavez, Dept Cardiovasc Biomed, Mexico City 14080, DF, Mexico.
EM elena.soto@cardiologia.org.mx; veronica.guarner@cardiologia.org.mx;
   eulisesd@yahoo.com; loe_mana@hotmail.com; a2novi@hotmail.com;
   rrvaldezvazquez@gmail.com; alfredoaisaa@gmail.com;
   huitzilihuitls@hotmail.com; israel.perez@cardiologia.org.mx
RI Pérez Torres, Israel/AAE-2579-2022; Saucedo-Orozco,
   Huitzilihuitl/CAG-8695-2022; V, Guarner/AFW-2513-2022
OI Saucedo-Orozco, Huitzilihuitl/0000-0002-4156-6364; Palacios,
   Adrian/0000-0003-2299-1581; Soto, Maria Elena/0000-0003-1332-2888
FU Consejo Nacional de Ciencia y Tecnologia (CONACYT) Mexico [312167]
FX This work was supported by Consejo Nacional de Ciencia y Tecnologia
   (CONACYT) Mexico, Project Number 312167.
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NR 76
TC 27
Z9 27
U1 0
U2 11
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2073-4409
J9 CELLS-BASEL
JI Cells
PD MAR
PY 2022
VL 11
IS 6
AR 932
DI 10.3390/cells11060932
PG 23
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA 0E8ZC
UT WOS:000776961500001
PM 35326383
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Abdelzaher, WY
   Bahaa, HA
   Toni, NDM
   Sanad, AS
AF Abdelzaher, Walaa Yehia
   Bahaa, Haitham Ahmed
   Toni, Nisreen D. M.
   Sanad, Ahmad Sameer
TI Mechanisms underlying the protective effect of montelukast in prevention
   of endometrial hyperplasia in female rats
SO INTERNATIONAL IMMUNOPHARMACOLOGY
LA English
DT Article
DE Endometrial hyperplasia; Estradiol valerate; Female rats; Montelukast
ID LEUKOTRIENE RECEPTOR ANTAGONIST; METABOLIC SYNDROME; OXIDATIVE STRESS;
   MOUSE MODEL; INFLAMMATION; CARCINOGENESIS; DISEASE; ESTRADIOL; CANCER;
   DAMAGE
AB Objective: To study the possible protective role of montelukast in endometrial hyperplesia (EH) rat model, induced by estradiol valerate (EV).
   Methods/materials: Thirty six female albino Wistar rats were classified into 7 groups: normal control, EV (2 mg/kg/day, p.o.), montelukast (10 mg/kg/day, p.o.), montelukast (1 mg/kg/day, p.o.) + EV (2 mg/kg/day, p.o.), montelukast (10 mg/kg/day, p.o.) + EV (2 mg/kg/day, p.o.), montelukast (20 mg/kg/day, p.o.) + EV (2 mg/kg/day, p.o.) groups. Uterine malondialdehyde (MDA), superoxide dismutase (SOD), total nitrites (NO) and serum total antioxidant capacity (TAC) were determined. Uterine, serum total cholesterol, high density lipoprotein (HDL) and tumor necrosis factor (TNF)-alpha were measured. Histopathological examination of the uterine tissue was also done. In addition, immunohistochemistry was done using Phosphatase and tensin homolog (PTEN) and inducible nitric oxide synthase (iNOS) antibodies.
   Results: Our results showed that montelukast in dose dependant manner improves oxidative stress, lipids profile and TNF alpha which were affected by EV. Moreover, immunohistochemical examination revealed that montelukast markedly reduced iNOS expression, while expression of PTEN was markedly enhanced, as compared to EV group. The protective effects of montelukast were also verified histopathologically.
   Conclusions: Montelukast in dose dependant manner provided biochemical and histo-pathological improvement in EV induced EH, through its anti-inflammatory, antioxidant activity and inhibition of iNOS expression with induction of PTEN expression.
C1 [Abdelzaher, Walaa Yehia] Menia Univ, Fac Med, Dept Pharmacol, Al Minya, Egypt.
   [Bahaa, Haitham Ahmed; Sanad, Ahmad Sameer] Menia Univ, Fac Med, Dept Obstet & Gynecol, Al Minya, Egypt.
   [Toni, Nisreen D. M.] Menia Univ, Fac Med, Dept Pathol, Al Minya, Egypt.
C3 Egyptian Knowledge Bank (EKB); Minia University; Egyptian Knowledge Bank
   (EKB); Minia University; Egyptian Knowledge Bank (EKB); Minia University
RP Abdelzaher, WY (corresponding author), Menia Univ, Fac Med, Dept Pharmacol, Al Minya, Egypt.
EM walaayehia22@yahoo.com
RI Abdelzaher, Walaa/W-1092-2019
OI Toni, Nisreen/0000-0002-1902-4745; bahaa, haitham/0000-0001-5271-7896
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NR 47
TC 13
Z9 14
U1 0
U2 7
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1567-5769
EI 1878-1705
J9 INT IMMUNOPHARMACOL
JI Int. Immunopharmacol.
PD SEP
PY 2018
VL 62
BP 326
EP 333
DI 10.1016/j.intimp.2018.07.008
PG 8
WC Immunology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Pharmacology & Pharmacy
GA GU5IA
UT WOS:000445318000039
PM 30056375
DA 2025-06-11
ER

PT J
AU Cherkas, A
   Zarkovic, N
AF Cherkas, Andriy
   Zarkovic, Neven
TI 4-Hydroxynonenal in Redox Homeostasis of Gastrointestinal Mucosa:
   Implications for the Stomach in Health and Diseases
SO ANTIOXIDANTS
LA English
DT Review
DE 4-hydroxynonenal; lipid peroxidation; redox balance; oxidative stress;
   stomach; peptic ulcer; gastritis; Helicobacter pylori; gastric cancer;
   non-steroid anti-inflammatory drugs-induced gastropathy
ID HELICOBACTER-PYLORI INFECTION; HEART-RATE-VARIABILITY;
   LIPID-PEROXIDATION; PEPTIC-ULCER; OXIDATIVE STRESS; INSULIN-RESISTANCE;
   GASTRIC-MUCOSA; METABOLIC SYNDROME; SERUM-ALBUMIN; FREE-RADICALS
AB Maintenance of integrity and function of the gastric mucosa (GM) requires a high regeneration rate of epithelial cells during the whole life span. The health of the gastric epithelium highly depends on redox homeostasis, antioxidant defense, and activity of detoxifying systems within the cells, as well as robustness of blood supply. Bioactive products of lipid peroxidation, in particular, second messengers of free radicals, the bellwether of which is 4-hydroxynonenal (HNE), are important mediators in physiological adaptive reactions and signaling, but they are also thought to be implicated in the pathogenesis of numerous gastric diseases. Molecular mechanisms and consequences of increased production of HNE, and its protein adducts, in response to stressors during acute and chronic gastric injury, are well studied. However, several important issues related to the role of HNE in gastric carcinogenesis, tumor growth and progression, the condition of GM after eradication of Helicobacter pylori, or the relevance of antioxidants for HNE-related redox homeostasis in GM, still need more studies and new comprehensive approaches. In this regard, preclinical studies and clinical intervention trials are required, which should also include the use of state-of-the-art analytical techniques, such as HNE determination by immunohistochemistry and enzyme-linked immunosorbent assay (ELISA), as well as modern mass-spectroscopy methods.
C1 [Cherkas, Andriy] Danylo Halystkyi Lviv Natl Med Univ, Dept Internal Med 1, UA-79010 Lvov, Ukraine.
   [Zarkovic, Neven] Inst Rudjer Boskovic, Lab Oxidat Stress LabOS, HR-10000 Zagreb, Croatia.
C3 Danylo Halytsky Lviv National Medical University; Rudjer Boskovic
   Institute
RP Zarkovic, N (corresponding author), Inst Rudjer Boskovic, Lab Oxidat Stress LabOS, HR-10000 Zagreb, Croatia.
EM cherkasandriy@yahoo.com; zarkovic@irb.hr
RI Cherkas, Andriy/H-8190-2018; Zarkovic, Neven/AAG-5836-2019
OI Cherkas, Andriy/0000-0002-6652-6983; Zarkovic, Neven/0000-0001-5032-0369
FU COST Action B35 "LPO-lipid peroxidation associated disorders"; COST
   Action "Chemistry of non-enzymatic protein modification-modulation of
   protein structure and function" [CM1001]; COST Action [BM1203]; COST
   Action "EU-ROS"; COST Action "New concepts and views in redox biology
   and oxidative stress research"; COST Action "Personalized Nutrition in
   aging society: redox control of major age-related diseases" [CA16112];
   Alexander Von Humboldt Foundation (Bonn, Germany)
FX This work was supported by COST Actions B35 "LPO-lipid peroxidation
   associated disorders", CM1001 "Chemistry of non-enzymatic protein
   modification-modulation of protein structure and function", "BM1203",
   "EU-ROS", "New concepts and views in redox biology and oxidative stress
   research", CA16112 "Personalized Nutrition in aging society: redox
   control of major age-related diseases", A.C. was supported by the Georg
   Forster (HERMES) Scholarship from Alexander Von Humboldt Foundation
   (Bonn, Germany).
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NR 89
TC 17
Z9 18
U1 0
U2 9
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD SEP
PY 2018
VL 7
IS 9
AR 118
DI 10.3390/antiox7090118
PG 14
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA GY2SO
UT WOS:000448393600009
PM 30177630
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Guo, W
   Li, YH
   Liang, W
   Wong, S
   Apovian, C
   Kirkland, JL
   Corkey, BE
AF Guo, Wen
   Li, Yahui
   Liang, Wentao
   Wong, Siu
   Apovian, Caroline
   Kirkland, James L.
   Corkey, Barbara E.
TI Beta-Mecaptoethanol Suppresses Inflammation and Induces Adipogenic
   Differentiation in 3T3-F442A Murine Preadipocytes
SO PLOS ONE
LA English
DT Article
ID NF-KAPPA-B; ACTIVATED RECEPTOR-GAMMA; NECROSIS-FACTOR-ALPHA; ADIPOCYTE
   DIFFERENTIATION; GENE-EXPRESSION; PPAR-GAMMA; DIETARY 2-MERCAPTOETHANOL;
   OXIDATIVE STRESS; NORMAL-WEIGHT; REDOX STATUS
AB Preadipocytes are present in adipose tissues throughout adult life that can proliferate and differentiate into mature adipocytes in response to environmental cues. Abnormal increase in adipocyte number or size leads to fat tissue expansion. However, it is now recognized that adipocyte hypertrophy is a greater risk factor for metabolic syndrome whereas fat tissue that continues to produce newer and smaller fat cells through preadipocyte differentiation is "metabolically healthy". Because adipocyte hypertrophy is often associated with increased oxidant stress and low grade inflammation, both are linked to disturbed cellular redox, we tested how preadipocyte differentiation may be regulated by beta-mercaptoethanol (BME), a pharmacological redox regulator and radical scavenger, using murine 3T3-F442A preadipocytes as the cell model. Effects of BME on adipogenesis were measured by microphotography, real-time PCR, and Western analysis. Our data demonstrated that preadipocyte differentiation could be regulated by extracellular BME. At an optimal concentration, BME enhanced expression of adipogenic gene markers and lipid accumulation. This effect was associated with BME-mediated down-regulation of inflammatory cytokine expression during early differentiation. BME also attenuated TNFalpha-induced activation of NFkappaB in differentiating preadipocytes and partially restored TNFalpha-mediated suppression on adipogenesis. Using a non-adipogenic HEK293 cell line transfected with luciferase reporter genes, we demonstrated that BME reduced basal and TNFalpha-induced NFkappaB activity and increased basal and ciglitazone-induced PPARgamma activity; both may contribute to the pro-adipogenic effect of BME in differentiating F442A preadipocytes.
C1 [Guo, Wen; Li, Yahui; Liang, Wentao; Wong, Siu; Apovian, Caroline; Corkey, Barbara E.] Boston Univ, Sch Med, Dept Med, Boston, MA 02118 USA.
   [Kirkland, James L.] Mayo Clin, Robert & Arlene Kogod Ctr Aging, Rochester, MN USA.
C3 Boston University; Mayo Clinic
RP Guo, W (corresponding author), Boston Univ, Sch Med, Dept Med, Boston, MA 02118 USA.
EM wguo@bu.edu
RI Liang, Wentao/AGK-2574-2022; Kirkland, James/F-9159-2016
OI Liang, Wentao/0000-0002-0609-6280; Guo, Wen/0000-0002-4474-2837;
   Apovian, Caroline/0000-0002-8029-1922
FU National Institutes of Health [AG013925, DK56690, AG037859]; Department
   of Medicine Bridge Fund
FX This work is supported by National Institutes of Health funding AG013925
   (JLK), DK56690 (BEC, WG), AG037859 (WG) and the Department of Medicine
   Bridge Fund (WG). The funders had no role in study design, data
   collection and analysis, decision to publish, or preparation of the
   manuscript.
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NR 78
TC 11
Z9 11
U1 0
U2 13
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JUL 23
PY 2012
VL 7
IS 7
AR e40958
DI 10.1371/journal.pone.0040958
PG 9
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 977TM
UT WOS:000306687700028
PM 22911724
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Zhang, XL
   Chen, Y
   Yang, HD
   Ding, H
   Cai, PP
   Ge, YP
   Zheng, HY
   Sun, XJ
   Yang, Y
   Li, XY
   Lin, T
AF Zhang, Xiaoli
   Chen, Yi
   Yang, Hedan
   Ding, Hui
   Cai, Pingping
   Ge, Yiping
   Zheng, Huiying
   Sun, Xiaojie
   Yang, Yin
   Li, Xinyu
   Lin, Tong
TI Plasma Metabolomics Indicates Potential Biomarkers and Abnormal
   Metabolic Pathways in Female Melasma Patients
SO ANNALS OF DERMATOLOGY
LA English
DT Article
DE Biomarkers; Melasma; Metabolic pathways; Metabolomics; Tryptophan
ID OXIDATIVE STRESS; MELANOGENESIS; EXPRESSION; SERUM
AB Background: Melasma is a common and chronic pigmentary disorder with complex pathogenesis, and the relationship between melasma and metabolic syndrome remains elusive. Thus, metabolomics might contribute to the early detection of potential metabolic abnormalities in individuals with melasma. Objective: The present study aims to analyze changes in plasma metabolites of female melasma patients and identify disease markers as well as explore potential therapeutic targets. Methods: Plasma samples from 20 female patients with melasma and 21 healthy female controls that were comparable in terms of age and body mass index were collected for untargeted metabolomics investigations. Ultra-high performance liquid chromatography-mass spectrometry was used to analyze metabolites in the plasma. Metabolic pathway analyses were employed to identify significantly differentially expressed metabolites in melasma patients. Receiver operating characteristic curves were constructed, and correlation analyses were performed using the modified Melasma Area and Severity Index and oxidative stress levels. Results: In contrast to healthy subjects, melasma patients showed significant alterations in 125 plasma metabolites, including amino acids, lipids, and carbohydrate-related metabolites. KEGG pathway analysis suggested that primary pathways associated with the development of melasma include tryptophan metabolism, as well as the biosynthesis of phenylalanine, tyrosine, and tryptophan. Importantly, based on receiver operating characteristic curves and correlation analyses, several metabolites were identified as robust biomarkers for melasma. Conclusion: Collectively, this study identified significant changes in plasma metabolites in melasma patients, providing new insights into the pathogenesis of melasma and opening novel therapeutic avenues.
C1 [Zhang, Xiaoli; Yang, Hedan; Ding, Hui; Cai, Pingping; Ge, Yiping; Zheng, Huiying; Sun, Xiaojie; Yang, Yin] Chinese Acad Med Sci & Peking Union Med Coll, Inst Dermatol, Dept Cosmet Laser Surg, 12 Jiangwangmiao Rd, Nanjing 210042, Peoples R China.
   [Chen, Yi; Li, Xinyu] Chinese Acad Med Sci & Peking Union Med Coll, Inst Dermatol, Pharmacal Res Lab, 12 Jiangwangmiao Rd, Nanjing 210042, Peoples R China.
   [Lin, Tong] Chinese Acad Med Sci & Peking Union Med Coll, Inst Dermatol, Jiangsu Key Lab Mol Biol Skin Dis & STIs, 12 Jiangwangmiao Rd, Nanjing 210042, Peoples R China.
C3 Chinese Academy of Medical Sciences - Peking Union Medical College;
   Institute of Dermatology - CAMS; Peking Union Medical College; Chinese
   Academy of Medical Sciences - Peking Union Medical College; Institute of
   Dermatology - CAMS; Peking Union Medical College; Chinese Academy of
   Medical Sciences - Peking Union Medical College; Peking Union Medical
   College; Institute of Dermatology - CAMS
RP Yang, Y (corresponding author), Chinese Acad Med Sci & Peking Union Med Coll, Inst Dermatol, Dept Cosmet Laser Surg, 12 Jiangwangmiao Rd, Nanjing 210042, Peoples R China.; Li, XY (corresponding author), Chinese Acad Med Sci & Peking Union Med Coll, Inst Dermatol, Pharmacal Res Lab, 12 Jiangwangmiao Rd, Nanjing 210042, Peoples R China.; Lin, T (corresponding author), Chinese Acad Med Sci & Peking Union Med Coll, Inst Dermatol, Jiangsu Key Lab Mol Biol Skin Dis & STIs, 12 Jiangwangmiao Rd, Nanjing 210042, Peoples R China.
EM yushiyy@163.com; xinyusli609@163.com; ddlin@hotmail.com
RI yang, yin/E-4198-2017; Ge, Yiping/HIR-6663-2022
OI Yang, Hedan/0000-0001-6649-550X; Yang, Yin/0000-0001-7469-4218; Sun,
   Xiaojie/0009-0004-0613-5448
FU CAMS Innovation Fund for Medical Sciences [CIFMS-2021-I2M-1-001,
   2022-I2M-CT-B-095]; National Natural Science Foundation of China
   [82103705]
FX The work was supported by the CAMS Innovation Fund for Medical Sciences
   (CIFMS-2021-I2M-1-001; 2022-I2M-C&T-B-095) and the National Natural
   Science Foundation of China (Grant no. 82103705) .
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NR 28
TC 0
Z9 0
U1 1
U2 4
PU KOREAN DERMATOLOGICAL ASSOC
PI SEOUL
PA 305 SEOCHO NASAN, SUITE OFFICE 1330-16, SEOCHO-2-DONG, SEOCHO-GU, SEOUL,
   137-858, SOUTH KOREA
SN 1013-9087
EI 2005-3894
J9 ANN DERMATOL
JI Ann. Dermatol.
PD OCT
PY 2024
VL 36
IS 5
BP 300
EP 309
DI 10.5021/ad.23.141
PG 10
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA H0U0U
UT WOS:001320670900006
PM 39343757
OA gold
DA 2025-06-11
ER

PT J
AU Baliou, S
   Ioannou, P
   Apetroaei, MM
   Vakonaki, E
   Fragkiadaki, P
   Kirithras, E
   Tzatzarakis, MN
   Arsene, AL
   Docea, AO
   Tsatsakis, A
AF Baliou, Stella
   Ioannou, Petros
   Apetroaei, Miruna-Maria
   Vakonaki, Elena
   Fragkiadaki, Persefoni
   Kirithras, Evangelos
   Tzatzarakis, Manolis N.
   Arsene, Andreea Letitia
   Docea, Anca Oana
   Tsatsakis, Aristides
TI The Impact of the Mediterranean Diet on Telomere Biology: Implications
   for Disease Management-A Narrative Review
SO NUTRIENTS
LA English
DT Review
DE telomere length; Mediterranean diet; polyphenols; vitamins; minerals;
   fatty acids; antioxidant; anti-inflammatory; diseases; autoimmunity
ID POLYUNSATURATED FATTY-ACIDS; CARDIOVASCULAR-DISEASE; OXIDATIVE-STRESS;
   VITAMIN-D; DNA-DAMAGE; GREEN TEA; ANTIOXIDANT CAPACITY; GENOMIC
   INSTABILITY; HOMOCYSTEINE LEVELS; METABOLIC SYNDROME
AB Introduction: Telomeres are nucleoprotein complexes at the ends of chromosomes that are under the control of genetic and environmental triggers. Accelerated telomere shortening is causally implicated in the increasing incidence of diseases. The Mediterranean diet has recently been identified as one that confers protection against diseases. This review aimed to identify the effect of each component of the Mediterranean diet on telomere length dynamics, highlighting the underlying molecular mechanisms. Methods: PubMed was searched to identify relevant studies to extract data for conducting a narrative review. Results: The Mediterranean diet alleviates clinical manifestations in many diseases. Focusing on autoimmune diseases, the Mediterranean diet can be protective by preventing inflammation, mitochondrial malfunction, and abnormal telomerase activity. Also, each Mediterranean diet constituent seems to attenuate aging through the sustenance or elongation of telomere length, providing insights into the underlying molecular mechanisms. Polyphenols, vitamins, minerals, and fatty acids seem to be essential in telomere homeostasis, since they inhibit inflammatory responses, DNA damage, oxidative stress, mitochondrial malfunction, and cell death and induce telomerase activation. Conclusions: The Mediterranean diet is beneficial for maintaining telomere dynamics and alleviating age-related illnesses. This review provides a comprehensive overview of cross-sectional, observational, and randomized controlled trials regarding the beneficial impact of every constituent in the Mediterranean diet on telomere length and chronic disease management.
C1 [Baliou, Stella; Vakonaki, Elena; Fragkiadaki, Persefoni; Kirithras, Evangelos; Tzatzarakis, Manolis N.; Tsatsakis, Aristides] Univ Crete, Med Sch, Lab Toxicol, Iraklion 71003, Greece.
   [Baliou, Stella; Vakonaki, Elena; Fragkiadaki, Persefoni; Kirithras, Evangelos; Tsatsakis, Aristides] Lifeplus SA, Sci & Technol Pk Crete, C Bldg, Vassilika Vouton 70013, Heraklion, Greece.
   [Ioannou, Petros] Univ Crete, Sch Med, Iraklion 71003, Greece.
   [Apetroaei, Miruna-Maria; Arsene, Andreea Letitia] Carol Davila Univ Med & Pharm, Fac Pharm, 6 Traian Vuia St, Bucharest 020956, Romania.
   [Docea, Anca Oana] Univ Med & Pharm Craiova, Dept Toxicol, Craiova 200349, Romania.
   [Docea, Anca Oana] Univ Med & Pharm, Fac Pharm, Dept Toxicol, Craiova 200349, Romania.
C3 University of Crete; University of Crete; Carol Davila University of
   Medicine & Pharmacy; University of Medicine & Pharmacy of Craiova;
   University of Medicine & Pharmacy of Craiova
RP Docea, AO (corresponding author), Univ Med & Pharm Craiova, Dept Toxicol, Craiova 200349, Romania.; Docea, AO (corresponding author), Univ Med & Pharm, Fac Pharm, Dept Toxicol, Craiova 200349, Romania.
EM s.baliou@med.uoc.gr; miruna-maria.apetroaei@rez.umfcd.ro;
   evakonaki@gmail.com; persefoni.f@gmail.com; vaggelis@libero.it;
   tzatzarakis@med.uoc.gr; andreea.arsene@umfcd.ro; daoana00@gmail.com;
   tsatsaka@uoc.gr
RI Docea, Anca/P-5807-2019; Vakonaki, Elena/MCX-6769-2025; Arsene,
   Andreea/AAD-4246-2020; Apetroaei, Miruna-Maria/IVU-7388-2023; TSATSAKIS,
   ARISTIDIS/H-2890-2013
OI Kirithras, Evangelos/0009-0007-2504-5407; Docea, Anca
   Oana/0000-0002-8162-5955; Ioannou, Petros/0000-0003-1082-5674; Arsene,
   Andreea Letitia/0000-0002-9478-6176; TSATSAKIS,
   ARISTIDIS/0000-0003-3824-2462; Apetroaei,
   Miruna-Maria/0009-0008-9574-7276
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PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
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SC Nutrition & Dietetics
GA C1M1E
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PM 39125404
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Deutsch, L
   Debevec, T
   Millet, GP
   Osredkar, D
   Opara, S
   Sket, R
   Murovec, B
   Mramor, M
   Plavec, J
   Stres, B
AF Deutsch, Leon
   Debevec, Tadej
   Millet, Gregoire P.
   Osredkar, Damjan
   Opara, Simona
   Sket, Robert
   Murovec, Bostjan
   Mramor, Minca
   Plavec, Janez
   Stres, Blaz
TI Urine and Fecal <SUP>1</SUP>H-NMR Metabolomes Differ Significantly
   between Pre-Term and Full-Term Born Physically Fit Healthy Adult Males
SO METABOLITES
LA English
DT Article
DE premature birth; H-1-NMR metabolomics; hypoxia; fecal metagenomics;
   biomarkers; activity; hypoxia
ID PULMONARY GAS-EXCHANGE; BILE-ACID METABOLISM; GUT MICROBIOTA; OXIDATIVE
   STRESS; EXERCISE CAPACITY; L-CARNITINE; BIRTH; SUCCINATE; HYPOXIA; HOST
AB Preterm birth (before 37 weeks gestation) accounts for similar to 10% of births worldwide and remains one of the leading causes of death in children under 5 years of age. Preterm born adults have been consistently shown to be at an increased risk for chronic disorders including cardiovascular, endocrine/metabolic, respiratory, renal, neurologic, and psychiatric disorders that result in increased death risk. Oxidative stress was shown to be an important risk factor for hypertension, metabolic syndrome and lung disease (reduced pulmonary function, long-term obstructive pulmonary disease, respiratory infections, and sleep disturbances). The aim of this study was to explore the differences between preterm and full-term male participants' levels of urine and fecal proton nuclear magnetic resonance (H-1-NMR) metabolomes, during rest and exercise in normoxia and hypoxia and to assess general differences in human gut-microbiomes through metagenomics at the level of taxonomy, diversity, functional genes, enzymatic reactions, metabolic pathways and predicted gut metabolites. Significant differences existed between the two groups based on the analysis of H-1-NMR urine and fecal metabolomes and their respective metabolic pathways, enabling the elucidation of a complex set of microbiome related metabolic biomarkers, supporting the idea of distinct host-microbiome interactions between the two groups and enabling the efficient classification of samples; however, this could not be directed to specific taxonomic characteristics.
C1 [Deutsch, Leon; Opara, Simona; Stres, Blaz] Univ Ljubljana, Biotech Fac, Dept Anim Sci, SI-1000 Ljubljana, Slovenia.
   [Debevec, Tadej] Univ Ljubljana, Fac Sports, SI-1000 Ljubljana, Slovenia.
   [Debevec, Tadej; Stres, Blaz] Jozef Stefan Inst, Dept Automat Biocybernet & Robot, SI-1000 Ljubljana, Slovenia.
   [Millet, Gregoire P.] Univ Lausanne, Inst Sport Sci, CH-1015 Lausanne, Switzerland.
   [Osredkar, Damjan] Univ Med Ctr Ljubljana, Univ Childrens Hosp, Dept Pediat Neurol, SI-1000 Ljubljana, Slovenia.
   [Osredkar, Damjan] Univ Ljubljana, Fac Med, SI-1000 Ljubljana, Slovenia.
   [Sket, Robert] Univ Med Ctr Ljubljana, Univ Childrens Hosp, Inst Special Lab Diagnost, SI-1000 Ljubljana, Slovenia.
   [Murovec, Bostjan] Univ Ljubljana, Fac Elect Engn, Jamova 2, SI-1000 Ljubljana, Slovenia.
   [Mramor, Minca] Univ Med Ctr Ljubljana, Dept Infect Dis, SI-1000 Ljubljana, Slovenia.
   [Plavec, Janez] NMR Ctr, Natl Inst Chem, SI-1000 Ljubljana, Slovenia.
   [Stres, Blaz] Univ Ljubljana, Fac Civil & Geodet Engn, Inst Sanit Engn, SI-1000 Ljubljana, Slovenia.
C3 University of Ljubljana; University of Ljubljana; Slovenian Academy of
   Sciences & Arts (SASA); Jozef Stefan Institute; University of Lausanne;
   University Medical Centre Ljubljana; University of Ljubljana; University
   Medical Centre Ljubljana; University of Ljubljana; University Medical
   Centre Ljubljana; National Institute of Chemistry - Slovenia; University
   of Ljubljana
RP Stres, B (corresponding author), Univ Ljubljana, Biotech Fac, Dept Anim Sci, SI-1000 Ljubljana, Slovenia.; Stres, B (corresponding author), Jozef Stefan Inst, Dept Automat Biocybernet & Robot, SI-1000 Ljubljana, Slovenia.; Stres, B (corresponding author), Univ Ljubljana, Fac Civil & Geodet Engn, Inst Sanit Engn, SI-1000 Ljubljana, Slovenia.
EM leon.deutsch@bf.uni-lj.si; tadej.debevec@fsp.uni-lj.si;
   gregoire.millet@unil.ch; damjan.osredkar@kclj.si;
   simona.konda@gmail.com; robert.sket@kclj.si;
   bostjan.murovec@fe.uni-lj.si; minca.mramor@kclj.si; janez.plavec@ki.si;
   blaz.stres@bf.uni-lj.si
RI Stres, Blaz/AAF-7279-2020; Millet, Guillaume/AAO-6520-2020; Debevec,
   Tadej/D-7917-2013; Osredkar, Damjan/B-6293-2011
OI Debevec, Tadej/0000-0001-7053-3978; Stres, Blaz/0000-0003-2972-2907;
   Millet, Gregoire/0000-0001-8081-4423; Deutsch, Leon/0000-0002-3739-8142;
   Murovec, Bostjan/0000-0002-1478-7380; Plavec, Janez/0000-0003-1570-8602;
   Osredkar, Damjan/0000-0002-2188-420X
FU Slovenian Research Agency (ARRS) [J3-7536]; Ljubljana University Medical
   Centre [TP20140088]; ARRS [P1-0242, 51867, P2-0095]
FX This research was funded by Slovenian Research Agency (ARRS)
   Cardio-respiratory responses during hypoxic exercise in individuals born
   prematurely-ARRS research project J3-7536, Ljubljana University Medical
   Centre (Grant No-TP20140088), ARRS grant no. P1-0242 and Young fellow
   scholarship MR+ (SRA R#51867) awarded to B.S. for L.D. BM was partially
   supported by ARRS grant no. P2-0095. The APC was funded by T.D.
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NR 130
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PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
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JI Metabolites
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PY 2022
VL 12
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AR 536
DI 10.3390/metabo12060536
PG 22
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 2J8QJ
UT WOS:000815914100001
PM 35736470
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Ghazizadeh, H
   Bohn, MK
   Yaghooti-Khorasani, M
   Ghaffarian-Zirak, R
   Valizadeh, M
   Saberi-Karimian, M
   Safarian, H
   Kamel-Khodabandeh, A
   Zare-Feyzabadi, R
   Timar, A
   Mohammadi-Bajgiran, M
   Oladi, MR
   Gachpazan, M
   Rohban, M
   Esmaily, H
   Ferns, GA
   Adeli, K
   Ghayour-Mobarhan, M
AF Ghazizadeh, Hamideh
   Bohn, Mary Kathryn
   Yaghooti-Khorasani, Mahdiyeh
   Ghaffarian-Zirak, Roshanak
   Valizadeh, Mohsen
   Saberi-Karimian, Maryam
   Safarian, Hamideh
   Kamel-Khodabandeh, Atieh
   Zare-Feyzabadi, Reza
   Timar, Ameneh
   Mohammadi-Bajgiran, Maryam
   Oladi, Mohammad Reza
   Gachpazan, Meysam
   Rohban, Mohadeseh
   Esmaily, Habibollah
   Ferns, Gordon A.
   Adeli, Khosrow
   Ghayour-Mobarhan, Majid
TI Age and sex-specific reference intervals for prooxidant-antioxidant
   balance, anti-heat-shock protein 27 (anti-hsp27), and routine laboratory
   tests in the middle-aged adult population
SO BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY
LA English
DT Article
DE anti-heat-shock protein 27; high-sensitivity C-reactive protein;
   laboratory biomarkers; prooxidant-antioxidant balance; reference
   interval
ID C-REACTIVE PROTEIN; PEDIATRIC REFERENCE INTERVALS;
   CORONARY-ARTERY-DISEASE; OXIDATIVE STRESS; CARDIOVASCULAR-DISEASE;
   METABOLIC SYNDROME; HORMONAL CHANGES; RISK; MARKERS; ASSOCIATION
AB Introduction We aimed to define specific reference intervals (RIs) for 11 biomarkers including inflammatory and oxidative stress biomarkers, liver, and renal function tests in a healthy Iranian adult population for the first time. Methods CLSI Ep28-A3 guidelines were then used to calculate accurate age- and sex- as well as body mass index (BMI)-specific RIs. Results RIs for studied biomarkers showed no significant age and sex-specific differences, except for uric acid, which had higher concentrations in men when compared to women. Additionally, after partitioning the participants based on the BMI with a cutoff point of 25 kg/m(2), only the levels of hs-CRP were positively associated with higher BMI (RI for BMI>25: 0.51-7.85 mg/L and for BMI<25: 0.40-4.46 mg/L). RI for PAB and anti-hsp-27 were reported 4.69-155.36 HK and 0.01-0.70 OD in men and women aged 35-65 years old. Conclusion Partitioning by sex and BMI was only required for uric acid and hs-CRP, respectively, while other biomarkers required no partitioning. These results can be expected to valuably contribute to improve laboratory test result interpretation in adults for improved monitoring of various diseases in the Iranian population.
C1 [Ghazizadeh, Hamideh] Mashhad Univ Med Sci, Student Res Comm, Mashhad, Iran.
   [Ghazizadeh, Hamideh; Yaghooti-Khorasani, Mahdiyeh; Ghaffarian-Zirak, Roshanak; Valizadeh, Mohsen; Safarian, Hamideh; Zare-Feyzabadi, Reza; Timar, Ameneh; Mohammadi-Bajgiran, Maryam; Oladi, Mohammad Reza; Gachpazan, Meysam; Rohban, Mohadeseh; Ghayour-Mobarhan, Majid] Mashhad Univ Med Sci, Metab Syndrome Res Ctr, Mashhad, Iran.
   [Ghazizadeh, Hamideh; Ghayour-Mobarhan, Majid] Mashhad Univ Med Sci, Int UNESCO Ctr Hlth, Related Basic Sci & Human Nutr, Mashhad, Iran.
   [Bohn, Mary Kathryn; Adeli, Khosrow] Hosp Sick Children, CALIPER Program, Div Clin Biochem, Pediat Lab Med, Toronto, ON, Canada.
   [Bohn, Mary Kathryn; Adeli, Khosrow] Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON, Canada.
   [Kamel-Khodabandeh, Atieh; Esmaily, Habibollah] Mashhad Univ Med Sci, Social Determinants Hlth Res Ctr, Mashhad, Iran.
   [Ferns, Gordon A.] Div Med Educ, Brighton & Sussex Med Sch, Brighton, England.
   [Saberi-Karimian, Maryam] Mashhad Univ Med Sci, Lung Dis Res Ctr, Mashhad, Iran.
C3 Mashhad University of Medical Sciences; Mashhad University of Medical
   Sciences; Mashhad University of Medical Sciences; University of Toronto;
   Hospital for Sick Children (SickKids); University of Toronto; Mashhad
   University of Medical Sciences; University of Sussex; University of
   Brighton; Mashhad University of Medical Sciences
RP Ghayour-Mobarhan, M (corresponding author), Mashhad Univ Med Sci, Int UNESCO Ctr Hlth, Related Basic Sci & Human Nutr, Mashhad, Iran.; Adeli, K (corresponding author), Univ Toronto, Hosp Sick Children, CALIPER Program, Div Clin Biochem,Pediat Lab Med, Mashhad, Iran.; Ghayour-Mobarhan, M (corresponding author), Mashhad Univ Med Sci, Sch Med, Metab Syndrome Res Ctr, Mashhad, Iran.
EM khosrow.adeli@sickkids.ca; ghayourm@mums.ac.ir
RI Ghayour-Mobarhan, Majid/AAY-5963-2020; Ghazizadeh, Hamideh/ABE-8941-2020
OI Yaghooti Khorasani, Mahdiyeh/0000-0001-5110-0851; Adeli,
   Khosrow/0000-0002-5839-5709
FU National Institutes for Medical Research Development (NIMAD) of Tehran;
   Mashhad University of Medical Sciences Research Council; Mashhad
   University of Medical Sciences, Mashhad, Iran; Elite Researcher Grant
   Committee from the NIMAD, Tehran, Iran [982966]
FX We would like to thank the National Institutes for Medical Research
   Development (NIMAD) of Tehran andMashhad University of Medical Sciences
   Research Council for their financial supports. The research reported in
   this publication was supported by Mashhad University of Medical
   Sciences, Mashhad, Iran, and Elite Researcher Grant Committee under
   award number from the NIMAD (982966), Tehran, Iran.
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NR 67
TC 2
Z9 2
U1 1
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0885-4513
EI 1470-8744
J9 BIOTECHNOL APPL BIOC
JI Biotechnol. Appl. Biochem.
PD JUN
PY 2022
VL 69
IS 3
BP 1300
EP 1310
DI 10.1002/bab.2203
EA AUG 2021
PG 11
WC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology
GA 2Q9YJ
UT WOS:000682533900001
PM 34028875
DA 2025-06-11
ER

PT J
AU De Campos, OC
   Osaigbovo, DI
   Bisi-Adeniyi, TI
   Iheagwam, FN
   Rotimi, SO
   Chinedu, SN
AF De Campos, Opeyemi Christianah
   Osaigbovo, Daniel Ikpomwosa
   Bisi-Adeniyi, Titilayo Ifeoluwa
   Iheagwam, Franklyn Nonso
   Rotimi, Solomon Oladapo
   Chinedu, Shalom Nwodo
TI Protective Role of Picralima nitida Seed Extract in High-Fat
   High-Fructose-Fed Rats
SO ADVANCES IN PHARMACOLOGICAL AND PHARMACEUTICAL SCIENCES
LA English
DT Article
ID INDUCED METABOLIC SYNDROME; DIET-INDUCED OBESITY; OXIDATIVE STRESS;
   INSULIN-RESISTANCE; MEDICINAL-PLANTS; APOCYNACEAE; LIVER;
   PATHOPHYSIOLOGY; HYPERGLYCEMIA; INFLAMMATION
AB Picralima nitida is a therapeutic herb used in ethnomedicine for the management of several disease conditions including diabetes. This study examined the potential palliative effect of aqueous seed extract of Picralima nitida (APN) on dyslipidemia, hyperglycemia, oxidative stress, insulin resistance, and the expression of some metabolic genes in high-fat high-fructose-fed rats. Experimental rats (2 months old) were fed a control diet or a high-fat diet with 25% fructose (HFHF diet) in their drinking water for nine weeks. APN was administered orally during the last four weeks. Anthropometric and antioxidant parameters, lipid profile, plasma glucose, and insulin levels and the relative expression of some metabolic genes were assessed. APN caused a significant decrease (P0.05) in weight gained, body mass index, insulin resistance, plasma glucose, and insulin levels. High-density lipoprotein cholesterol level was significantly increased (P0.05), while triacylglycerol, cholesterol, low-density lipoprotein, cardiac index, atherogenic index, coronary artery index, and malondialdehyde levels in plasma and liver samples were also significantly decreased (P0.05) by APN at all experimental doses when compared to the group fed with an HFHF diet only. APN also significantly (P0.05) upregulated the relative expression of glucokinase, carnitine palmitoyltransferase-1 (CPT-1), and leptin at 400 mg/kg body weight when compared to the group fed with an HFHF diet only. This study showed that APN alleviated dyslipidemia, hyperglycemia, and oxidant effect associated with the intake of a high-fat high-fructose diet.
C1 [De Campos, Opeyemi Christianah; Osaigbovo, Daniel Ikpomwosa; Bisi-Adeniyi, Titilayo Ifeoluwa; Iheagwam, Franklyn Nonso; Rotimi, Solomon Oladapo; Chinedu, Shalom Nwodo] Covenant Univ, Dept Biochem, Coll Sci & Technol, PMB 1023, Ota, Ogun State, Nigeria.
   [De Campos, Opeyemi Christianah; Iheagwam, Franklyn Nonso; Rotimi, Solomon Oladapo; Chinedu, Shalom Nwodo] Covenant Univ, Publ Hlth & Wellbeing Res Cluster CUPHERC, PMB 1023, Ota, Ogun State, Nigeria.
C3 Covenant University; Covenant University
RP De Campos, OC (corresponding author), Covenant Univ, Dept Biochem, Coll Sci & Technol, PMB 1023, Ota, Ogun State, Nigeria.; De Campos, OC (corresponding author), Covenant Univ, Publ Hlth & Wellbeing Res Cluster CUPHERC, PMB 1023, Ota, Ogun State, Nigeria.
EM opeyemi.decampos@covenantuniversity.edu.ng; osaigbovodaniel35@gmail.com;
   ifeoluwabisiadeniyi13@gmail.com;
   franklyn.iheagwam@covenantuniversity.edu.ng;
   ola.rotimi@covenantuniversity.edu.ng;
   shalom.chinedu@covenantuniversity.edu.ng
RI Rotimi, Solomon/H-8683-2012; Chinedu, Shalom Nwodo/B-5956-2016;
   Iheagwam, Franklyn/J-4716-2016
OI De Campos, Opeyemi/0000-0001-9094-5670; Chinedu, Shalom
   Nwodo/0000-0001-6421-2043; Iheagwam, Franklyn/0000-0001-8487-4052
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NR 70
TC 2
Z9 2
U1 0
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2633-4682
EI 2633-4690
J9 ADV PHARM PHARM SCI
JI Adv. Pharm. Pharm. Sci.
PD OCT 24
PY 2020
VL 2020
AR 5206204
DI 10.1155/2020/5206204
PG 11
WC Pharmacology & Pharmacy
WE Emerging Sources Citation Index (ESCI)
SC Pharmacology & Pharmacy
GA OT3NS
UT WOS:000590757600001
PM 33163962
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Kudoh, A
   Satoh, H
   Hirai, H
   Watanabe, T
   Shimabukuro, M
AF Kudoh, Akihiro
   Satoh, Hiroaki
   Hirai, Hiroyuki
   Watanabe, Tsuyoshi
   Shimabukuro, Michio
TI Preliminary Evidence for Adipocytokine Signals in Skeletal Muscle
   Glucose Uptake
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Article
DE adipose tissue; insulin resistance; adipocytokines; glucose transporter
   4; skeletal muscle
ID INDUCED INSULIN-RESISTANCE; NECROSIS-FACTOR-ALPHA; METABOLIC SYNDROME;
   OXIDATIVE STRESS; CARDIAC-MUSCLE; RAT ADIPOCYTES; CELLS; ACTIVATION;
   EXPRESSION; OBESITY
AB The cross talk between the adipose tissue and insulin target tissues is a key mechanism for obesity-associated insulin resistance. However, the precise role of the interaction between the skeletal muscle and adipose tissue for insulin signaling and glucose uptake is questionable. L6 myocytes were co-cultured with or without 3T3-L1 adipocytes (similar to 5 x 10(3) cells/cm(2)) up to 24 h. Glucose uptake was evaluated by 2-[H-3] deoxyglucose uptake assay. Levels of mRNA expression of Glutl and Glut4 and mitochondrial enzymes were analyzed by quantitative real-time reverse transcription polymerase chain reaction. Levels of Glutl and Glut4 protein and phosphorylation of Akt (Ser473 and Thr308) were analyzed by immunoblotting. Study 1: co-culture with 3T3-L1 adipocytes increased glucose uptake in dose- and time-dependent manner in L6 myocytes under insulin-untreated conditions. When co-cultured with 3T3-L1 cells, reactive oxygen species production and levels of Glutl mRNA and protein were increased in L6 cells, while these changes were abrogated and the glucose uptake partially inhibited by antioxidant treatment. Study 2: co-culture with 3T3-L1 adipocytes suppressed insulin-stimulated glucose uptake in L6 myocytes. Insulin-induced Akt phosphorylation at Ser473 decreased, which was proportional to 3T3-L1 density. Antioxidant treatment partially reversed this effect. Interactions between skeletal muscle and adipose tissues are important for glucose uptake under insulin-untreated or -treated condition through oxygen stress mechanism.
C1 [Kudoh, Akihiro; Hirai, Hiroyuki; Shimabukuro, Michio] Fukushima Med Univ, Dept Diabet Endocrinol & Metab, Fukushima, Japan.
   [Satoh, Hiroaki] Juntendo Univ, Grad Sch Med, Dept Endocrinol & Metab, Tokyo, Japan.
   [Watanabe, Tsuyoshi] Fukushima Rosai Hosp, Dept Internal Med, Iwaki, Fukushima, Japan.
C3 Fukushima Medical University; Juntendo University
RP Kudoh, A; Shimabukuro, M (corresponding author), Fukushima Med Univ, Dept Diabet Endocrinol & Metab, Fukushima, Japan.
EM a-kudoh@fmu.ac.jp; mshimabukuro-ur@umin.ac.jp
RI Satoh, Hiroaki/E-9096-2017
OI hirai, hiroyuki/0000-0001-5325-3827
FU JSPS [17K00924, 16K09363, 16K01823, 24659570]; Grants-in-Aid for
   Scientific Research [16K09363, 24659570, 16K01823, 17K00924] Funding
   Source: KAKEN
FX This work was supported in part by JSPS Grant-in-Aid for Challenging
   Exploratory Research #24659570 (HS) and for Scientific Research
   #17K00924 (AK), #16K09363 (HS), and #16K01823 (MS).
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NR 34
TC 6
Z9 7
U1 1
U2 12
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD JUN 7
PY 2018
VL 9
AR 295
DI 10.3389/fendo.2018.00295
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA GI5DV
UT WOS:000434392100001
PM 29930536
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Sebert, S
   Sharkey, D
   Budge, H
   Symonds, ME
AF Sebert, Sylvain
   Sharkey, Don
   Budge, Helen
   Symonds, Michael E.
TI The early programming of metabolic health: is epigenetic setting the
   missing link?
SO AMERICAN JOURNAL OF CLINICAL NUTRITION
LA English
DT Article; Proceedings Paper
CT International Conference on The Power of Programming - Developmental
   Origins of Health and Disease
CY MAY 06-08, 2010
CL Univ Munich Med Ctr, Munich, GERMANY
SP Early Nutr Acad, European Early Nutr Programming Project, Dev Origins Hlth & Dis Soc, Abbott Nutr Hlth Inst/Abbott Nutr, Danone Baby Nutr/Danone Res, Nestle Nutr Inst, Ferrero MSC GmbH & Co KG, S.A. Beneo Orafti, Biovitrum AB, DSM Nutrit Prod Ltd, Fresenius Kabi Deutschland GmbH, Labs Ordesa SL, Life Measurement Inc, Martek Corp
HO Univ Munich Med Ctr
ID MATERNAL NUTRIENT RESTRICTION; CATCH-UP GROWTH; FTO GENE; PROTEIN
   RESTRICTION; ADIPOSE-TISSUE; BIRTH-WEIGHT; INSULIN-RESISTANCE; MAMMALIAN
   TARGET; POSTNATAL-GROWTH; LATE-GESTATION
AB Adult health is dependent, in part, on maternal nutrition and growth during early life, which may independently affect insulin sensitivity, body composition, and overall energy homeostasis. Since the publication of the "thrifty phenotype hypothesis" by Hales and Barker (Diabetologia 1992;35:595-601), animal experiments have focused on establishing the mechanisms involved, which include changes in fetal cortisol, insulin, and leptin secretion or sensitivity. Intrauterine growth retardation can be induced by either prolonged modest changes in maternal diet or by more severe changes in uterine blood supply near to term. These contrasting challenges result in different amounts of cellular stress in the offspring. In addition, shifts in the transcriptional activity of DNA may produce sustained metabolic adaptations. Within tissues and organs that control metabolic homeostasis (eg, hypothalamus, adipose tissue, stomach, skeletal muscle, and heart), a range of phenotypes can be induced by sustained changes in maternal diet via modulation of genes that control DNA methylation and by histone acetylation, which suggests epigenetic programming. We now need to understand how changes in maternal diet affect DNA and how they are conserved on exposure to oxidative stress. A main challenge will be to establish how the dietary environment interacts with the programmed phenotype to trigger the development of metabolic disease. This may aid in the establishment of nutrigenomic strategies to prevent the metabolic syndrome. Am J Clin Nutr 2011;94(suppl):1953S-8S.
C1 Univ Nottingham Hosp, Early Life Nutr Res Unit, Acad Div Child Hlth, Nottingham NG7 2UH, England.
   Univ Nottingham Hosp, Nottingham Resp Med Biomed Res Unit, Sch Clin Sci, Nottingham NG7 2UH, England.
C3 University of Nottingham; University of Nottingham
RP Symonds, ME (corresponding author), Univ Nottingham Hosp, Early Life Nutr Res Unit, Div Human Dev, Nottingham NG7 2UH, England.
EM michael.symonds@nottingham.ac.uk
OI Sharkey, Don/0000-0002-4989-8697; Sebert, Sylvain/0000-0001-6681-6983;
   Symonds, Michael/0000-0001-9649-8963
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NR 62
TC 88
Z9 94
U1 1
U2 27
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0002-9165
EI 1938-3207
J9 AM J CLIN NUTR
JI Am. J. Clin. Nutr.
PD DEC
PY 2011
VL 94
IS 6
BP 1953S
EP 1958S
DI 10.3945/ajcn.110.001040
PG 6
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Nutrition & Dietetics
GA 852PA
UT WOS:000297368700086
PM 21543542
OA Bronze
DA 2025-06-11
ER

PT J
AU Sreedharan, S
   Zouganelis, G
   Drake, SJ
   Tripathi, G
   Kermanizadeh, A
AF Sreedharan, Sreejesh
   Zouganelis, Georgios
   Drake, Samantha J.
   Tripathi, Gyanendra
   Kermanizadeh, Ali
TI Nanomaterial-induced toxicity in pathophysiological models
   representative of individuals with pre-existing medical conditions
SO JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS
LA English
DT Review
DE Engineered nanomaterials; pre-existing disease; toxicity; inflammation;
   oxidative stress; genotoxicity; hazard assessment
ID ZINC-OXIDE NANOPARTICLES; ALLERGIC AIRWAY INFLAMMATION; MULTIWALLED
   CARBON NANOTUBES; TITANIUM-DIOXIDE TIO2; SILVER NANOPARTICLES; OXIDATIVE
   STRESS; CARDIOVASCULAR-DISEASE; INHALATION EXPOSURE; LIPID
   NANOPARTICLES; METABOLIC SYNDROME
AB The integration of nanomaterials (NMs) into an ever-expanding number of daily used products has proven to be highly desirable in numerous industries and applications. Unfortunately, the same "nano" specific physicochemical properties, which make these materials attractive, may also contribute to hazards for individuals exposed to these materials. In 2021, it was estimated that 7 out of 10 deaths globally were accredited to chronic diseases, such as chronic liver disease, asthma, and cardiovascular-related illnesses. Crucially, it is also understood that a significant proportion of global populace numbering in the billions are currently living with a range of chronic undiagnosed health conditions. Due to the significant number of individuals affected, it is important that people suffering from chronic disease also be considered and incorporated in NM hazard assessment strategies. This review examined and analyzed the literature that focused on NM-induced adverse health effects in models which are representative of individuals exhibiting pre-existing medical conditions with focus on the pulmonary, cardiovascular, hepatic, gastrointestinal, and central nervous systems. The overall objective of this review was to outline available data, highlighting the important role of pre-existing disease in NM-induced toxicity with the aim of establishing a weight of evidence approach to inform the public on the potential hazards posed by NMs in both healthy and compromised persons in general population.
C1 [Sreedharan, Sreejesh; Zouganelis, Georgios; Drake, Samantha J.; Tripathi, Gyanendra; Kermanizadeh, Ali] Univ Derby, Human Sci Res Ctr, Derby, England.
C3 University of Derby
RP Kermanizadeh, A (corresponding author), Univ Derby, Human Sci Res Ctr, Derby, England.
EM a.kermanizadeh@derby.ac.uk
RI Kermanizadeh, Ali/AAD-6281-2019; Tripathi, Gyanendra/C-8832-2011; Drake,
   Samantha/CAI-2975-2022; Kermanizadeh, Ali/L-9691-2017
OI Zouganelis, George/0000-0003-4746-2416; Kermanizadeh,
   Ali/0000-0002-2989-9078; Drake, Samantha/0000-0002-9748-2856;
   Sreedharan, Dr/0000-0001-9523-0404
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NR 125
TC 7
Z9 8
U1 2
U2 10
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1093-7404
EI 1521-6950
J9 J TOXICOL ENV HEAL B
JI J. Toxicol. Env. Health-Pt b-Crit. Rev.
PD JAN 2
PY 2023
VL 26
IS 1
BP 1
EP 27
DI 10.1080/10937404.2022.2153456
EA DEC 2022
PG 27
WC Environmental Sciences; Public, Environmental & Occupational Health;
   Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health; Toxicology
GA AW5A5
UT WOS:000897155600001
PM 36474307
OA hybrid
DA 2025-06-11
ER

PT J
AU Gong, M
   Wen, S
   Nguyen, T
   Wang, CX
   Jin, JL
   Zhou, LG
AF Gong, Min
   Wen, Song
   Nguyen, Thiquynhnga
   Wang, Chaoxun
   Jin, Jianlan
   Zhou, Ligang
TI Converging Relationships of Obesity and Hyperuricemia with Special
   Reference to Metabolic Disorders and Plausible Therapeutic Implications
SO DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
LA English
DT Review
DE obesity; hyperuricemia; pathophysiology; complication; pharmacotherapy
ID HEPATIC INSULIN-RESISTANCE; SERUM URIC-ACID; ADIPOSE-TISSUE
   INFLAMMATION; GLUCAGON-LIKE PEPTIDE-1; BODY-MASS INDEX; OXIDATIVE
   STRESS; GUT MICROBIOTA; MELANOCORTIN-4 RECEPTOR; CARDIOVASCULAR-DISEASE;
   WEIGHT-LOSS
AB Background: Obesity and hyperuricemia mutually influence metabolic syndrome. This study discusses the metabolic relationships between obesity and hyperuricemia in terms of pathophysiology, complications, and treatments.
   Methods: We searched for preclinical or clinical studies on the pathophysiology, complications, and therapy of obesity and hyperuricemia on the PubMed database.
   Results: In this systemic review, we summarized our searching results on topics of pathophysiology, complications and therapeutic strategy. In pathophysiology, we firstly introduce genetic variations for obesity, hyperuricemia and their relationships by genetic studies. Secondly, we talk about the epigenetic influences on obesity and hyperuricemia. Thirdly, we describe the central metabolic regulation and the role of hyperuricemia. Then, we refer to the character of adipose tissue inflammation and oxidative stress in the obesity and hyperuricemia. In the last part of this topic, we reviewed the critical links of gut microbiota in the obesity and hyperuricemia. In the following part, we review the pathophysiology of major complications in obesity and hyperuricemia including insulin resistance and type 2 diabetes mellitus, chronic kidney disease, cardiovascular diseases, and cancers. Finally, we recapitulate the therapeutic strategies especially the novel pharmaceutic interventions for obesity and hyperuricemia, which concurrently show the mutual metabolic influences between two diseases.
   Conclusion: The data reviewed here delineate the metabolic relationships between obesity and hyperuricemia, and provide a comprehensive overview of the therapeutic targets for the management of metabolic syndromes.
C1 [Gong, Min; Wen, Song; Nguyen, Thiquynhnga; Wang, Chaoxun; Jin, Jianlan; Zhou, Ligang] Fudan Univ, Dept Endocrinol, Shanghai Pudong Hosp, Shanghai 201399, Peoples R China.
C3 Fudan University
RP Zhou, LG (corresponding author), Fudan Univ, Dept Endocrinol, Shanghai Pudong Hosp, Shanghai 201399, Peoples R China.
EM zhouligang@yahoo.com
RI Min, Gong/AAW-2473-2021
OI Wen, Song/0000-0001-6173-0507
FU National Natural Science Foundation of China [81370932]; Key Studies
   (Special) Department Fund of the Pudong, New Area Health Planning
   Commission [PWZzk2017-03]; Integrative Medicine special fund of Shanghai
   Municipal Health Planning Committee [ZHYY-ZXYJHZX-2-201712]; Outstanding
   Leaders Training Program of Pudong Health Bureau of Shanghai
   [PWR12014-06]; Outstanding Clinical Discipline Project of Shanghai
   Pudong [PWYgy-2018-08]; Natural Science Foundation of China [21675034];
   Shanghai Natural Science Foundation [19ZR1447500]
FX This work was supported by National Natural Science Foundation of China
   (81370932), the Key Studies (Special) Department Fund of the Pudong, New
   Area Health Planning Commission (PWZzk2017-03), and Integrative Medicine
   special fund of Shanghai Municipal Health Planning Committee
   (ZHYY-ZXYJHZX-2-201712), Outstanding Leaders Training Program of Pudong
   Health Bureau of Shanghai (PWR12014-06), the Outstanding Clinical
   Discipline Project of Shanghai Pudong (PWYgy-2018-08), the Natural
   Science Foundation of China (Project no. 21675034), Shanghai Natural
   Science Foundation (19ZR1447500).
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NR 238
TC 49
Z9 57
U1 6
U2 46
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-7007
J9 DIABET METAB SYND OB
JI Diabetes Metab. Syndr. Obes.
PY 2020
VL 13
BP 943
EP 962
DI 10.2147/DMSO.S232377
PG 20
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA KZ0UJ
UT WOS:000522986800001
PM 32280253
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Serviddio, G
   Bellanti, F
   Villani, R
   Tamborra, R
   Zerbinati, C
   Blonda, M
   Ciacciarelli, M
   Poli, G
   Vendemiale, G
   Iuliano, L
AF Serviddio, Gaetano
   Bellanti, Francesco
   Villani, Rosanna
   Tamborra, Rosanna
   Zerbinati, Chiara
   Blonda, Maria
   Ciacciarelli, Marco
   Poli, Giuseppe
   Vendemiale, Gianluigi
   Iuliano, Luigi
TI Effects of dietary fatty acids and cholesterol excess on liver injury: A
   lipidomic approach
SO REDOX BIOLOGY
LA English
DT Article
DE Oxysterols; Non-alcoholic fatty liver disease; Cholesterol excess; Fatty
   acids
ID METABOLIC SYNDROME; OXIDATIVE STRESS; PATHOGENESIS; OXYSTEROLS; PLASMA;
   STEATOHEPATITIS; CYTOTOXICITY; AUTOXIDATION; EXPRESSION; PATHWAYS
AB Lipid accumulation is the hallmark of Non-alcoholic Fatty Liver Disease (NAFLD) and has been suggested to play a role in promoting fatty liver inflammation. Previous findings indicate that during oxidative stress conditions excess cholesterol autoxidizes to oxysterols. To date, the role of oxysterols and their potential interaction with fatty acids accumulation in NASH pathogenesis remains little investigated.
   We used the nutritional model of high fatty acids (HFA), high cholesterol (HCh) or high fat and high cholesterol (HFA+FCh) diets and explored by a lipidomic approach, the blood and liver distribution of fatty acids and oxysterols in response to dietary manipulation. We observed that HFA or HCh diets induced fatty liver without inflammation, which was otherwise observed only after supplementation of HFA+HCh. Very interestingly, the combination model was associated with a specific oxysterol fingerprint.
   The present work provides a complete analysis of the change in lipids and oxysterols profile induced by different lipid dietary model and their association with histological alteration of the liver. This study allows the generation of interesting hypotheses on the role of interaction of lipid and cholesterol metabolites in the liver injury during NAFLD development and progression. Moreover, the changes in the concentration and quality of oxysterols induced by a combination diet suggest a novel potential pathogenic mechanism in the progression from simple steatosis to steatohepatitis. (C) 2016 The Authors. Published by Elsevier B.V.
C1 [Serviddio, Gaetano; Bellanti, Francesco; Villani, Rosanna; Tamborra, Rosanna; Blonda, Maria; Vendemiale, Gianluigi] Univ Foggia, Dept Med & Surg Sci, Inst Internal Med, CURE Univ Ctr Liver Dis Res & Treatment, I-71122 Foggia, Italy.
   [Zerbinati, Chiara; Ciacciarelli, Marco; Iuliano, Luigi] Sapienza Univ Rome, Dept Med Surg Sci & Biotechnol, Lab Vasc Biol & Mass Spectrometry, I-04100 Latina, Italy.
   [Poli, Giuseppe] Univ Turin, San Luigi Gonzaga Hosp, Dept Clin & Biol Sci, I-10043 Turin, Orbassano, Italy.
C3 University of Foggia; Sapienza University Rome; Azienda
   Ospedaliero-Universitaria San Luigi Gonzaga; University of Turin
RP Serviddio, G (corresponding author), Univ Foggia, CURE Univ Ctr Liver Dis Res & Treatment, Dept Med & Surg Sci, Viale Pinto 1, I-71122 Foggia, Italy.
EM gaetano.serviddio@unifg.it
RI Bellanti, Francesco/K-4059-2016; Ciacciarelli, Marco/HSG-4468-2023;
   serviddio, gaetano/C-7629-2011; Villani, Rosanna/K-5753-2018; Iuliano,
   Luigi/A-5266-2008
OI Villani, Rosanna/0000-0001-9875-019X; BELLANTI,
   Francesco/0000-0002-8196-7373; Iuliano, Luigi/0000-0002-0027-9326
FU Italian Society of Internal Medicine (SIMI); Regione Puglia (Future In
   Research Project)
FX The present research was partially funded by the Italian Society of
   Internal Medicine (SIMI). Francesco Bellanti was granted by Regione
   Puglia (Future In Research Project).
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NR 37
TC 43
Z9 45
U1 0
U2 6
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 2213-2317
J9 REDOX BIOL
JI Redox Biol.
PD OCT
PY 2016
VL 9
BP 296
EP 305
DI 10.1016/j.redox.2016.09.002
PG 10
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA EA6RQ
UT WOS:000386757000031
PM 27639112
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Chielle, EO
   de Souza, WM
   da Silva, TP
   Moresco, RN
   Moretto, MB
AF Chielle, Eduardo Ottobelli
   de Souza, Willian Marciel
   da Silva, Thainan Paz
   Moresco, Rafael Noal
   Moretto, Maria Beatriz
TI Adipocytokines, inflammatory and oxidative stress markers of clinical
   relevance altered in young overweight/obese subjects
SO CLINICAL BIOCHEMISTRY
LA English
DT Article
DE Obesity; Adipocytokines; Adenosine deaminase; Dipeptidyl peptidase-IV;
   Young adult
ID RETINOL-BINDING-PROTEIN; INSULIN-RESISTANCE; ANTIOXIDANT CAPACITY;
   ADENOSINE-DEAMINASE; METABOLIC SYNDROME; VISCERAL FAT; OBESE;
   INTERLEUKIN-6; RECEPTOR; TISSUE
AB Objective: The aim of the study was to assess the influence of overweight and obesity in youth on adipocytokines levels, inflammatory and oxidative markers.
   Design and methods: Cross-sectional study of 149 young adults (54 normal weight, 27 overweight, 68 obese). Clinical and biochemical parameters, including lipid profile, fasting glucose, insulin and HOMA were determined. The levels of adipocytokines(adiponectin, retinol-binding protein 4 (RBP4), and resistin), markers of inflammation (high-sensitivity C-reactive protein (hs-CRP) adenosine deaminase (ADA), dipeptidyl peptidase-IV (DPP-IV) activities, serum IL-6 levels and oxidative stress (malondialdehyde and ferric reducing antioxidant power - FRAP) were measured.
   Results: Obese subjects presented significantly lower levels of Sulfhydryl groups (SH groups), adiponectin, HDL-C and the highest levels of RBP4, hs-CRP, resistin, IL-6, ADA, DPP-IV activities, and oxidative markers than compared to those who were of normal weight. There was a positive correlation between hs-CRP, IL-6, DDP-IV activity, anthropometric measurements and biochemical parameters.
   Conclusions: This analysis shows that resistin, RBP4, IL-6, ADA and DPP-IV activities and the reduction of adiponectin can promote inflammation, impairment of insulin sensitivity, and may contribute development of the pathways involved in obesity. These findings may hold promise in identifying new inflammatory markers, benchmarks that assist in the diagnosis and monitoring of patients with overweight and obese. (C) 2016 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
C1 [Chielle, Eduardo Ottobelli; da Silva, Thainan Paz; Moresco, Rafael Noal; Moretto, Maria Beatriz] Univ Fed Santa Maria, Ctr Hlth Sci, Dept Clin & Toxicol Anal, BR-97105900 Santa Maria, RS, Brazil.
   [Moresco, Rafael Noal; Moretto, Maria Beatriz] Univ Fed Santa Maria, Ctr Hlth Sci, BR-97105900 Santa Maria, RS, Brazil.
   [Chielle, Eduardo Ottobelli; de Souza, Willian Marciel] Univ West Santa Catarina, Ctr Hlth Sci, UNOESC, BR-89900000 Sao Miguel Do Oeste, SC, Brazil.
C3 Universidade Federal de Santa Maria (UFSM); Universidade Federal de
   Santa Maria (UFSM); Universidade do Oeste de Santa Catarina
RP Moretto, MB (corresponding author), Univ Fed Santa Maria, Ctr Hlth Sci, Dept Clin & Toxicol Anal, BR-97105900 Santa Maria, RS, Brazil.
EM beatriz@smail.ufsm.br
RI Moresco, Rafael/K-6118-2017; Souza, William/D-3044-2017
OI Moresco, Rafael/0000-0003-3072-5080; Souza, William/0000-0002-0025-8293
FU National Council for Scientific and Technological Development
   (CNPq/Brazil) [477029/2011-6, 308617/2014-2]
FX This study was supported by scholarships from the National Council for
   Scientific and Technological Development (CNPq/Brazil) (numbers
   477029/2011-6- M.B.Moretto and 308617/2014-2-R.N.Moresco).
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NR 46
TC 24
Z9 27
U1 0
U2 11
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0009-9120
EI 1873-2933
J9 CLIN BIOCHEM
JI Clin. Biochem.
PD MAY
PY 2016
VL 49
IS 7-8
BP 548
EP 553
DI 10.1016/j.clinbiochem.2016.01.003
PG 6
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA DL1TO
UT WOS:000375415500006
PM 26794633
DA 2025-06-11
ER

PT J
AU Rabelo, LA
   Alenina, N
   Bader, M
AF Rabelo, Luiza A.
   Alenina, Natalia
   Bader, Michael
TI ACE2-angiotensin-(1-7)-Mas axis and oxidative stress in cardiovascular
   disease
SO HYPERTENSION RESEARCH
LA English
DT Review
DE Ang-(1-7)/ACE2/MAS axis; cardiovascular disease; oxidative stress;
   vascular function
ID ANGIOTENSIN-CONVERTING ENZYME; NITRIC-OXIDE SYNTHASE;
   SMOOTH-MUSCLE-CELLS; IMPROVES ENDOTHELIAL FUNCTION; COUPLED-RECEPTOR
   MAS; II TYPE-1 RECEPTOR; E-DEFICIENT MICE; NADPH OXIDASE; METABOLIC
   SYNDROME; VASCULAR DYSFUNCTION
AB The renin-angiotensin-aldosterone system (RAAS) is a pivotal regulator of physiological homeostasis and diseases of the cardiovascular system. Recently, new factors have been discovered, such as angiotensin-converting enzyme 2 (ACE2), angiotensin-(1-7) and Mas. This newly defined ACE2-angiotensin-(1-7)-Mas axis was shown to have a critical role in the vasculature and in the heart, exerting mainly protective effects. One important mechanism of the classic and the new RAAS regulate vascular function is through the regulation of redox signaling. Angiotensin II is a classic prooxidant peptide that increases superoxide production through the activation of NAD(P) H oxidases. This review summarizes the current knowledge about the ACE2-angiotensin-(1-7)-Mas axis and redox signaling in the context of cardiovascular regulation and disease. By interacting with its receptor Mas, angiotensin-(1-7) induces the release of nitric oxide from endothelial cells and thereby counteracts the effects of angiotensin II. ACE2 converts angiotensin II to angiotensin-(1-7) and, thus, is a pivotal regulator of the local effects of the RAAS on the vessel wall. Taken together, the ACE2-angiotensin-(1-7)-Mas axis emerges as a novel therapeutic target in the context of cardiovascular and metabolic diseases. Hypertension Research (2011) 34, 154-160; doi: 10.1038/hr.2010.235; published online 2 December 2010
C1 [Rabelo, Luiza A.; Alenina, Natalia; Bader, Michael] Max Delbruck Ctr Mol Med, D-13125 Berlin, Germany.
   [Rabelo, Luiza A.] Univ Fed Alagoas, Inst Ciencias Biol & Saude, Setor Fisiol & Farmacol, Lab Reatividade Cardiovasc, Maceio, Alagoas, Brazil.
C3 Helmholtz Association; Max Delbruck Center for Molecular Medicine;
   Universidade Federal de Alagoas
RP Bader, M (corresponding author), Max Delbruck Ctr Mol Med, Robert Rossle St 10, D-13125 Berlin, Germany.
EM mbader@mdc-berlin.de
RI Bader, Michael/K-2124-2013; Rabêlo, Luiza/S-4050-2019
OI Bader, Michael/0000-0003-4780-4164
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NR 95
TC 128
Z9 145
U1 0
U2 17
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0916-9636
EI 1348-4214
J9 HYPERTENS RES
JI Hypertens. Res.
PD FEB
PY 2011
VL 34
IS 2
BP 154
EP 160
DI 10.1038/hr.2010.235
PG 7
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 717CL
UT WOS:000287020000001
PM 21124322
OA Bronze
DA 2025-06-11
ER

PT J
AU Nespolo, RJS
   Veras, ASC
   Marin, LCS
   de Oliveira, MJ
   Santos, AD
   Pereira, EHP
   de Souza, FLA
   Pacagnelli, FL
   Castilho, C
   Teixeira, GR
   Castoldi, RC
   Giometti, IC
AF Nespolo, Ronivania Jenuario Silva
   Veras, Allice Santos Cruz
   Marin, Lauren Chrys Soato
   de Oliveira, Margarete Jardinetti
   Santos, Aline de Oliveira
   Pereira, Evellin Heloisa Paulineli
   de Souza, Francilene Lima Agostinho
   Pacagnelli, Francis Lopes
   Castilho, Calie
   Teixeira, Giovana Rampazzo
   Castoldi, Robson Chacon
   Giometti, Ines Cristina
TI High-intensity interval training reduces inflammatory mediator levels in
   the testes of spontaneously hypertensive rats
SO ANIMAL REPRODUCTION
LA English
DT Article
DE exercise; hormonal dosage; interleukin; testosterone; TNF alpha
ID CARDIOVASCULAR-DISEASE RISK; METABOLIC SYNDROME; OXIDATIVE STRESS;
   BLOOD-PRESSURE; EXERCISE; INTERLEUKIN-6; TESTOSTERONE; PROLACTIN; IL-6;
   DYSFUNCTION
AB Hypertension is an age-related pathology that causes a decline in the function of all organ systems, including the reproductive system, due to its association with increased oxidative stress and inflammation. The inflammatory cytokine levels increase as a result of hypertension and cause inflammation and tissue injury. Although high-intensity interval training (HIIT) has shown promise as a nondrug treatment for hypertensive individuals, its effects on the reproductive system of hypertensive individuals remain unknown. The aim of this study was to investigate the effects of HIIT on plasma hormone concentrations and the expression of inflammatory mediators in the testes of spontaneously hypertensive rats (SHRs). Male SHRs were divided into 2 groups: SHR (control, n=8) and HIIT (SHRs subjected to HIIT on a treadmill for 8 weeks, n=9) groups. The expression of inflammatory mediators (TNF alpha and IL-6) in the testes and testosterone, prolactin, and corticosterone concentrations in plasma were measured. No difference in TNF alpha expression was found between the groups. The groups also showed no significant differences in hormone levels. However, SHRs that underwent HIIT showed lower immunostaining for IL-6 in their testes than did SHRs that did not undergo HIIT training (P < 0.05) and the HIIT group presented lower lower systolic blood pressure than did the SHR group. We concluded that HIIT for two months reduces the BSP and IL-6 levels in the testes of hypertensive rats.
C1 [Nespolo, Ronivania Jenuario Silva; Marin, Lauren Chrys Soato; de Oliveira, Margarete Jardinetti; Santos, Aline de Oliveira; Pereira, Evellin Heloisa Paulineli; de Souza, Francilene Lima Agostinho; Pacagnelli, Francis Lopes; Castilho, Calie; Giometti, Ines Cristina] Univ Oeste Paulista, Presidente Prudente, SP, Brazil.
   [Veras, Allice Santos Cruz; Teixeira, Giovana Rampazzo] Univ Estadual Paulista, Soc Brasileira Fisiol, Programa Posgrad Multictr Ciencias Fisiol, Presidente Prudente, SP, Brazil.
   [Teixeira, Giovana Rampazzo] Univ Estadual Paulista, Fac Ciencias & Tecnol, Presidente Prudente, SP, Brazil.
   [Castoldi, Robson Chacon] Univ Norte Parana, Programa Posgrad Exercicio Fis Promocao Saude, Londrina, PR, Brazil.
C3 Universidade do Oeste Paulista; Sociedade Brasileira de Fisiologia;
   Universidade Estadual Paulista; Universidade Estadual Paulista;
   University Norte Parana
RP Giometti, IC (corresponding author), Univ Oeste Paulista, Presidente Prudente, SP, Brazil.
EM inesgiometti@yahoo.com.br
RI Teixeira, Giovana/C-1342-2012; Giometti, Ines/I-4786-2012; Castoldi,
   Robson/F-4209-2018; Veras, Allice/AAT-7160-2020; Pacagnelli,
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FU So Paulo State Research Support Foundation-FAPESP [2018/22682-0]; CNPq
   [163635/2018-8]
FX ICG received funding for this research from S & atilde;o Paulo State
   Research Support Foundation-FAPESP (grant number #2018/22682-0) . EHPP
   forthe PIBIC and PIBIC-EM scholarships from CNPq (grant number
   #163635/2018-8) .
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NR 68
TC 0
Z9 0
U1 0
U2 0
PU BRAZILIAN COLL ANIMAL REPRODUCTION
PI BELO HORIZONTE
PA ALAMEDA DAS PRINCESAS, 1275-BAIRRO SAO JOSE, BELO HORIZONTE, MG
   31275-180, BRAZIL
SN 1806-9614
EI 1984-3143
J9 ANIM REPROD
JI Anim. Reprod.
PY 2025
VL 22
IS 2
AR e20240024
DI 10.1590/1984-3143-AR2024-0024
PG 13
WC Agriculture, Dairy & Animal Science; Reproductive Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture; Reproductive Biology
GA 2KT7X
UT WOS:001485001000001
PM 40357058
DA 2025-06-11
ER

PT J
AU Choudhuri, S
   Sarkar, S
   Chowdhury, PR
   Choudhuri, D
   Das, S
AF Choudhuri, Soma
   Sarkar, Susmita
   Chowdhury, Panisree R.
   Choudhuri, Dipayan
   Das, Sandeep
TI Dietary calcium improves the reproductive functions against high-fat
   diet (HFD)-induced testicular toxicity in male obese rats
SO NUTRIRE
LA English
DT Article
DE Obesity; Calcium; Sperm; Testosterone; Oxidative stress; Inflammation
ID METABOLIC SYNDROME; PARAMETERS
AB IntroductionObesity-associated metabolic disorders are often associated with reproductive disorders affecting the spermatogenesis program and infertility. Recently, dietary calcium has shown a protective effect against obesity and its associated metabolic disorders. Calcium is a common nutrient in our daily diet with a diverse physiological role, but its role against reproductive function during obesity remains unknown.PurposeThe present study aimed to investigate the dietary effect of calcium against male reproductive function in high-fat diet (HFD) rats.MethodsMale rats were randomly divided into four groups: the control group, the HFD obese group, the low calcium (0.25% Ca) HFD group, and the high calcium (1.0%Ca) HFD group. The rats were fed with the low or high-calcium diet for 12 weeks after inducing obesity. At the end of the study, several reproductive markers including sperm count, testicular steroidogenic enzymatic activity, testosterone, antioxidant, inflammatory and apoptotic markers were studied.ResultsHigh calcium (1.0% Ca) group was found to improve the reproductive parameters like sperm count, sperm motility, testosterone level, and steroidogenic enzymes indicating improvement in spermatogenesis which is affected by diet-induced obesity. These improvements in reproductive parameters are improved by restoring the physiological balance between antioxidant and oxidative stress levels and reducing the inflammatory and apoptosis markers in the high calcium group.ConclusionHigh calcium diet during obese conditions seemed to improve the male reproductive parameters and spermatogenesis program thereby preventing the risk of obesity-associated male infertility.
C1 [Choudhuri, Soma; Sarkar, Susmita; Chowdhury, Panisree R.; Choudhuri, Dipayan; Das, Sandeep] Tripura Univ, Dept Human Physiol, Agartala 799022, Tripura, India.
   [Choudhuri, Soma] Tripura Med Coll & Dr BR Ambedkar Teaching Hosp, Dept Physiol, Agartala 799014, Tripura, India.
C3 Tripura University
RP Das, S (corresponding author), Tripura Univ, Dept Human Physiol, Agartala 799022, Tripura, India.
EM sandeepdas11196@gmail.com
OI Das, Sandeep/0000-0002-6722-3909
FU Indian Council of Medical Research (ICMR), Govt. of India
   [5/7/1213/2014-RCH, 5/7/1617/2018]
FX This study was funded by the Indian Council of Medical Research (ICMR),
   Govt. of India, grant number (5/7/1213/2014-RCH and 5/7/1617/2018 RBMH &
   CH).
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NR 41
TC 0
Z9 0
U1 1
U2 1
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
EI 2316-7874
J9 NUTRIRE
JI Nutrire
PD NOV 27
PY 2023
VL 48
IS 2
AR 55
DI 10.1186/s41110-023-00243-6
PG 11
WC Food Science & Technology; Nutrition & Dietetics
WE Emerging Sources Citation Index (ESCI)
SC Food Science & Technology; Nutrition & Dietetics
GA XE3U0
UT WOS:001259976000001
DA 2025-06-11
ER

PT J
AU Ribeiro, PVM
   Tavares, JF
   Costa, MAC
   Mattar, JB
   Alfenas, RCG
AF Ribeiro, Priscila V. M.
   Tavares, Juliana F.
   Costa, Mirian A. C.
   Mattar, Jessica B.
   Alfenas, Rita C. G.
TI Effect of reducing dietary advanced glycation end products on
   obesity-associated complications: a systematic review
SO NUTRITION REVIEWS
LA English
DT Review
DE advanced glycation end product; RAGE; insulin resistance; NF-kappa B;
   ROS; pathway PI3K-AKT; dietary recommendations; dietary AGEs; obesity;
   renal injury and endothelial dysfunction
ID ADVANCED GLYCOSYLATION; INSULIN-RESISTANCE; OXIDATIVE STRESS;
   NITRIC-OXIDE; TRANSCRIPTION FACTOR; METABOLIC SYNDROME; AGE RESTRICTION;
   INFLAMMATION; ENDPRODUCTS; GLYCOTOXINS
AB Context: Consumption of dietary advanced glycation end products (AGEs) is associated with oxidative stress, inflammation, and other chronic conditions commonly associated with obesity. Objective: To analyze the effects of dietary AGEs on complications associated with obesity. Data sources: This systematic review was conducted and reported according to PRISMA guidelines. The PubMed, Cochrane, and Scopus databases were searched, using the terms "advanced glycation end products," "overweight," and "obesity." The last search was performed in October 2018. Data extraction: Six studies that evaluated the effects of low-AGE and high-AGE diets were included in the review. The duration of the studies ranged from 1 day to 12weeks. A comparison of all the compiled data was conducted by the authors. Data analysis: Circulating and urinary AGE markers, besides soluble receptor for AGEs, were considered as the primary outcomes. The secondary outcomes were cardiometabolic, inflammatory, glycemic, anthropometric, and renal markers. Conclusions: AGE-RAGE interactions can activate the NF-kappa B (nuclear factor kappa B) signaling pathway and inhibit the PI3K-AKT pathway in adipocytes, which may explain their association with chronic diseases. This interaction can be considered as a novel explanation for the pathogenesis of obesity. AGEs can also be used as a biomarker for monitoring responses to dietary interventions in overweight and obese people.
C1 [Ribeiro, Priscila V. M.; Tavares, Juliana F.; Costa, Mirian A. C.; Mattar, Jessica B.; Alfenas, Rita C. G.] Univ Fed Vicosa, Dept Nutr & Hlth, Ave PH Rolfs S-N, BR-36570900 Vicosa, MG, Brazil.
C3 Universidade Federal de Vicosa
RP Ribeiro, PVM (corresponding author), Univ Fed Vicosa, Dept Nutr & Hlth, Ave PH Rolfs S-N, BR-36570900 Vicosa, MG, Brazil.
EM priscilavazdemelo@yahoo.com.br
RI de Melo Ribeiro, Priscila/AAO-8190-2020
OI Alfenas, Rita/0000-0003-2290-1611; de Campos Costa, Mirian
   Aparecida/0000-0003-0532-5798; Bevenuto Mattar,
   Jessica/0000-0001-7229-1984
FU Fundacao de Amparo a Pesquisa do Estado de Minas Gerais (FAPEMIG,
   Brazil); Coordenacao de Aperfeicoamento de Pessoal de Ensino Superior
   (CAPES, Brazil); Conselho Nacional de Desenvolvimento Cientifico e
   Tecnologico (CNPq, Brazil)
FX The authors thank Fundacao de Amparo a Pesquisa do Estado de Minas
   Gerais (FAPEMIG, Brazil), Coordenacao de Aperfeicoamento de Pessoal de
   Ensino Superior (CAPES, Brazil) (PVMR, MACC and JBM's scholarships), and
   Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq,
   Brazil) for the RCGA's Research Productivity Grant.
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NR 60
TC 31
Z9 32
U1 0
U2 37
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0029-6643
EI 1753-4887
J9 NUTR REV
JI Nutr. Rev.
PD OCT
PY 2019
VL 77
IS 10
BP 725
EP 734
DI 10.1093/nutrit/nuz034
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA JF2ZR
UT WOS:000491255400004
PM 31228247
OA Bronze
DA 2025-06-11
ER

PT J
AU Maruhashi, T
   Hisatome, I
   Kihara, Y
   Higashi, Y
AF Maruhashi, Tatsuya
   Hisatome, Ichiro
   Kihara, Yasuki
   Higashi, Yukihito
TI Hyperuricemia and endothelial function: From molecular background to
   clinical perspectives
SO ATHEROSCLEROSIS
LA English
DT Review
DE Uric acid; Endothelial function; Xanthine oxidase; Uric acid transporter
ID SERUM URIC-ACID; XANTHINE-OXIDASE INHIBITION; HIGH-DOSE ALLOPURINOL;
   LEFT-VENTRICULAR MASS; CARDIOVASCULAR-DISEASE; OXIDATIVE STRESS;
   METABOLIC SYNDROME; RISK-FACTOR; DYSFUNCTION; ATHEROSCLEROSIS
AB Uric acid is the end product of purine metabolism catalyzed by xanthine oxidase in humans. In the process of purine metabolism, reactive oxygen species, including superoxide, are generated concomitantly with uric acid production, which may deteriorate endothelial function through the reaction of superoxide with nitric oxide (NO), leading to decreased NO bioavailability and increased production of peroxynitrite, a reactive oxidant. Therefore, xanthine oxidase may be a therapeutic target in the treatment of endothelial dysfunction. Indeed, clinical studies have shown that endothelial dysfunction is restored by treatment with a xanthine oxidase inhibitor in patients with cardiovascular risk factors. However, it has not been fully determined whether uric acid per se is an independent causal risk factor of endothelial dysfunction in humans. Although experimental studies have indicated that uric acid absorbed into endothelial cells via the activation of uric acid transporters expressed in endothelial cells causes endothelial dysfunction through increased oxidative stress and inflammation, an actual biological effect of uric acid on endothelial function in vivo has not been fully elucidated, in part, because of the difficulty in investigating the effect of uric acid alone on endothelial function due to the close associations of uric acid with other conventional cardiovascular risk factors and the complicated relationship between uric acid and endothelial function attributed to the potent antioxidant properties of uric acid. In this review, we focus on the relationship between uric acid and endothelial function from molecular to clinical perspectives.
C1 [Maruhashi, Tatsuya; Kihara, Yasuki] Hiroshima Univ, Dept Cardiovasc Med, Grad Sch Biomed Sci, Hiroshima, Japan.
   [Hisatome, Ichiro] Tottori Univ, Inst Regenerat Med & Biofunct, Div Regenerat Med & Therapeut, Dept Genet Med & Regenerat Therapeut,Grad Sch Med, Yonago, Tottori, Japan.
   [Higashi, Yukihito] Hiroshima Univ Hosp, Div Regenerat & Med, Hiroshima, Japan.
   [Higashi, Yukihito] Hiroshima Univ, Res Inst Radiat Biol & Med, Dept Cardiovasc Regenerat & Med, Hiroshima, Japan.
C3 Hiroshima University; Tottori University; Hiroshima University;
   Hiroshima University
RP Higashi, Y (corresponding author), Hiroshima Univ, Dept Cardiovasc Regenerat & Med, RIRBM, Minami Ku, 1-2-3 Kasumi, Hiroshima 7348553, Japan.
EM yhigashi@hiroshima-u.ac.jp
RI Higashi, Yukihito/G-5343-2019
FU Ministry of Education, Science and Culture of Japan [1859081500,
   21590898]; Japanese Arteriosclerosis Prevention Fund; Grants-in-Aid for
   Scientific Research [21590898] Funding Source: KAKEN
FX This study was supported in part by a Grant-in-Aid for Scientific
   Research from the Ministry of Education, Science and Culture of Japan
   (1859081500 and 21590898) and a Grant in Aid of Japanese
   Arteriosclerosis Prevention Fund.
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NR 79
TC 163
Z9 177
U1 1
U2 37
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0021-9150
EI 1879-1484
J9 ATHEROSCLEROSIS
JI Atherosclerosis
PD NOV
PY 2018
VL 278
BP 226
EP 231
DI 10.1016/j.atherosclerosis.2018.10.007
PG 6
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA HB4WA
UT WOS:000451056500029
PM 30326405
OA hybrid
DA 2025-06-11
ER

PT J
AU Emre, S
   Asli, S
   Sener, M
   Eker, SS
   Esma, SG
AF Emre, Sarandol
   Asli, Sarandol
   Sener, Mercan
   Eker, Salih Saygin
   Esma, Surmen-Gur
TI Antipsychotic-Treated Schizophrenia Patients Develop Inflammatory and
   Oxidative Responses Independently From Obesity: However, Metabolic
   Disturbances Arise From Schizophrenia-Related Obesity
SO HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL
LA English
DT Article
DE cytokine; inflammatory markers; obesity; oxidative stress; schizophrenia
ID SERUM; CYTOKINES; LEPTIN; ACID
AB Objective: To define the impact of obesity on inflammatory and oxidative disturbances in antipsychotic-treated schizophrenia patients. Methods: Several cytokines, inflammatory, metabolic, and oxidative status markers were evaluated in obese (n = 40) and non-obese (n = 40) antipsychotic-treated patients and compared with age-and BMI-matched controls (n = 80). Results: Schizophrenia patients had higher leptin, TNF-alpha, adiponectin, visfatin, resistin, P-selectin, NPY, BDNF, CD40-L, MCP-1, and malondialdehyde, and lower IL-6, ghrelin, neopterin, and vitamin E levels compared to their respective controls (p < 0.001). Total oxidant status was higher in non-obese patients compared to controls (p < 0.001), total antioxidant capacity was higher in obese compared to non-obese patients (p < 0.01), but vitamin A and paraoxonase levels were not different. High sensitive-CRP levels were higher in obsese controls relative to non-obese controls (p < 0.05) and in obese patients relative to non-obese patients (p < 0.001). Fasting glucose, insulin, HbA1c, HOMA-IR, uric acid, total cholesterol, and triglyceride concentrations were higher in obese patients compared to non-obese patients. Insulin concentrations and HOMA-IR were also higher in obese controls than in non-obese controls. Conclusions: Our results suggest that inflammatory responses and oxidative stress develop independently from obesity in antipsychotic-treated schizophrenia patients. However, schizophrenia-induced obesity causes metabolic disturbances; thereby, obese schizophrenia patients are more liable to cardiovascular events and progress of metabolic syndrome than non-obese patients.
C1 [Emre, Sarandol; Esma, Surmen-Gur] Bursa Uludag Univ, Med Fac, Dept Med Biochem, Bursa, Turkiye.
   [Asli, Sarandol; Sener, Mercan; Eker, Salih Saygin] Bursa Uludag Universitiy, Med Fac, Dept Psychiat, Bursa, Turkiye.
C3 Uludag University; Uludag University
RP Emre, S (corresponding author), Bursa Uludag Univ, Med Fac, Dept Med Biochem, Bursa, Turkiye.
EM sarandol@uludag.edu.tr
RI Surmen-Gur, Esma/AAG-7327-2021
OI Sarandol, Emre/0000-0002-2593-7196; EKER, SALIH
   SAYGIN/0000-0003-4629-8669
FU Bursa Uludagbreve; niversitesi
FX The authors are grateful to Prof. Dr. Guven Ozkaya for his guidance and
   assistance in statistical evaluation of the data of this study.
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NR 34
TC 0
Z9 0
U1 5
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0885-6222
EI 1099-1077
J9 HUM PSYCHOPHARM CLIN
JI Hum. Psychopharmacol.-Clin. Exp.
PD NOV
PY 2024
VL 39
IS 6
AR e2913
DI 10.1002/hup.2913
EA NOV 2024
PG 10
WC Clinical Neurology; Pharmacology & Pharmacy; Psychiatry; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry;
   Psychology
GA L9Z8X
UT WOS:001355349900001
PM 39511900
OA hybrid
DA 2025-06-11
ER

PT J
AU Zanko, A
   Siewko, K
   Kretowski, AJ
   Milewski, R
AF Zanko, Adrianna
   Siewko, Katarzyna
   Kretowski, Adam Jacek
   Milewski, Robert
TI Lifestyle, Insulin Resistance and Semen Quality as Co-Dependent Factors
   of Male Infertility
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Review
DE fertility; insulin resistance; semen quality; lifestyle
ID POLYCYSTIC-OVARY-SYNDROME; SPERM QUALITY; DASH DIET; MEDITERRANEAN DIET;
   WAIST CIRCUMFERENCE; METABOLIC SYNDROME; PHYSICAL-ACTIVITY; OXIDATIVE
   STRESS; SATURATED FAT; MEAT INTAKE
AB Infertility is a problem that affects millions of couples around the world. It is known as a disease of couples, not individuals, which makes diagnosis difficult and treatment unclear. Male infertility can have many causes, from mechanical ones to abnormal spermatogenesis or spermiogenesis. Semen quality is determined by a number of factors, including those dependent on men themselves, with the number of infertile men growing every year. These include, e.g., diet, physical activity, sleep quality, stress, among many others. As these factors co-exist with insulin resistance, which is a disease closely related to lifestyle, it has been singled out in the study due to its role in affecting semen quality. In order to examine connections between lifestyle, insulin resistance, and semen quality, a review of literature published from 1989 to 2020 in the following databases PubMed/Medline, EMBASE (Elsevier), Scopus, Web of Science, and Google Scholar was performed. Hence, semen quality, environment, and insulin resistance are interrelated, thus it is difficult to indicate which aspect is the cause and which is the effect in a particular relationship and the nature of possible correlations. Since the influence of lifestyle on semen quality has been extensively studied, it is recommended that more thorough research be done on the relationship between insulin resistance and semen quality, comparing the semen quality of men with and without insulin resistance.
C1 [Zanko, Adrianna] Med Univ Bialystok, Doctoral Sch, PL-15089 Bialystok, Poland.
   [Siewko, Katarzyna; Kretowski, Adam Jacek] Med Univ Bialystok, Dept Endocrinol Diabetol & Internal Med, PL-15276 Bialystok, Poland.
   [Milewski, Robert] Med Univ Bialystok, Dept Biostat & Med Informat, PL-15295 Bialystok, Poland.
C3 Medical University of Bialystok; Medical University of Bialystok;
   Medical University of Bialystok
RP Milewski, R (corresponding author), Med Univ Bialystok, Dept Biostat & Med Informat, PL-15295 Bialystok, Poland.
EM robert.milewski@umb.edu.pl
RI Siewko, Katarzyna/U-7997-2018; Kretowski, Adam/U-6299-2018; Milewski,
   Robert/S-6539-2018
OI Milewski, Robert/0000-0001-6241-8283
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NR 123
TC 15
Z9 17
U1 1
U2 5
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD JAN
PY 2023
VL 20
IS 1
AR 732
DI 10.3390/ijerph20010732
PG 14
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA 7Q0LH
UT WOS:000909087800001
PM 36613051
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU González-Torres, L
   Matos, C
   Vázquez-Velasco, M
   Santos-López, JA
   Sánchez-Martínez, I
   García-Fernández, C
   Bastida, S
   Benedí, J
   Sánchez-Muniz, FJ
AF Gonzalez-Torres, Laura
   Matos, Catia
   Vazquez-Velasco, Miguel
   Santos-Lopez, Jorge A.
   Sanchez-Martinez, Iria
   Garcia-Fernandez, Camino
   Bastida, Sara
   Benedi, Juana
   Sanchez-Muniz, Francisco J.
TI Glucomannan- and glucomannan plus spirulina-enriched pork affect liver
   fatty acid profile, LDL receptor expression and antioxidant status in
   Zucker fa/fa rats fed atherogenic diets
SO FOOD & NUTRITION RESEARCH
LA English
DT Article
DE Glucomannan; spirulina; functional meats; oxidative stress; fatty acid
   profile; hypercholesterolemia
ID KONJAC GLUCOMANNAN; ARYLESTERASE ACTIVITY; SERUM-LIPOPROTEINS;
   RESTRUCTURED PORK; OXIDATIVE STRESS; GENE-EXPRESSION; RISK-FACTORS;
   LONG-TERM; CHOLESTEROL; GLUCOSE
AB We evaluated the effects of glucomannan or glucomannan plus spirulina-restructured pork (RP) on liver fatty acid profile, desaturase/elongase enzyme activities and oxidative status of Zucker fa/fa rats for seven weeks. Control (C), glucomannan (G) and glucomannan/spirulina (GS)-RP; HC (cholesterol-enriched control), HG and HGS (cholesterol-enriched glucomannan and glucomannan/spirulina-RP) experimental diets were tested. Increased metabolic syndrome markers were found in C, G and GS rats. Cholesterol feeding increased liver size, fat, and cholesterol and reduced antioxidant enzyme levels and expressions. Cholesterolemia was lower in HG and HGS than in HC. GS vs. G showed higher stearic but lower oleic levels. SFA and PUFA decreased while MUFA increased by cholesterol feeding. The arachidonic/linoleic and docosahexaenoic/alphalinolenic ratios were lower in HC, HG, and HGS vs. C, G, and GS, respectively, suggesting a delta-6-elongase-desaturase system inhibition. Moreover, cholesterol feeding, mainly in HGS, decreased low-density-lipoprotein receptor expression and the delta-5-desaturase activity and increased the delta-9-desaturase activity. In conclusion, the liver production of highly unsaturated fatty acids was limited to decrease their oxidation in presence of hypercholesterolaemia. Glucomannan or glucomannan/spirulina-RP has added new attributes to their functional properties in meat, partially arresting the negative effects induced by high-fat-high-cholesterol feeding on the liver fatty acid and antioxidant statuses.
C1 [Gonzalez-Torres, Laura; Matos, Catia; Vazquez-Velasco, Miguel; Sanchez-Martinez, Iria; Bastida, Sara; Sanchez-Muniz, Francisco J.] Univ Complutense Madrid, Fac Farm, Dept Nutr & Bromatol Nutr 1, Madrid, Spain.
   [Santos-Lopez, Jorge A.; Benedi, Juana] Univ Complutense Madrid, Fac Farm, Dept Farmacol, Madrid, Spain.
   [Garcia-Fernandez, Camino] Univ Leon, Fac Vet, Dept Nutr, Leon, Spain.
C3 Complutense University of Madrid; Complutense University of Madrid;
   Universidad de Leon
RP Sánchez-Muniz, FJ (corresponding author), Univ Complutense Madrid, Fac Farm, Dept Nutr & Bromatol 1, Plaza Ramon y Cajal S-N, Madrid 28040, Spain.
EM frasan@ucm.es
RI Velasco, M./AAA-9858-2019; Bastida, Sara/L-1619-2014; GonzálezTorres,
   Laura/AAE-6577-2019; Santos-López, Jorge/L-5371-2019; Sanchez-Muniz,
   Francisco J/K-9795-2014
OI Sanchez-Martinez, Iria/0000-0001-5210-212X; Sanchez-Muniz, Francisco
   J/0000-0002-2660-5126; Vazquez-Velasco, Miguel/0000-0002-4168-2234;
   GonzalezTorres, Laura/0000-0002-1589-2190; Santos-Lopez, Jorge
   Arturo/0000-0003-4924-0809
FU Spanish projects [AGL-2008-04892-C03-02]; Consolider-Ingenio 2010
   project [CSD2007-00016]; Consejo Nacional de Ciencia y Tecnologia
   (CONACYT)
FX This work was supported by the Spanish projects;
   [AGL-2008-04892-C03-02]; Consolider-Ingenio 2010 project; [#
   CSD2007-00016]; Consejo Nacional de Ciencia y Tecnologia (CONACYT).
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NR 60
TC 10
Z9 11
U1 0
U2 12
PU SWEDISH NUTRITION FOUNDATION-SNF
PI LUND
PA IDEON SCIENCE PARK, BESOK SCHEELEV 17 BETA 5, 3V, LUND, 223 70, SWEDEN
SN 1654-6628
EI 1654-661X
J9 FOOD NUTR RES
JI Food Nutr. Res.
PY 2017
VL 61
AR 1264710
DI 10.1080/16546628.2017.1264710
PG 14
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA EO7PI
UT WOS:000396882200001
PM 28325998
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Kamiya, T
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AF Kamiya, Tetsuro
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TI The effect of hypoxia mimetic cobalt chloride on the expression of
   EC-SOD in 3T3-L1 adipocytes
SO REDOX REPORT
LA English
DT Article
DE extracellular-superoxide dismutase; adiponectin; tumor necrosis
   factor-alpha; c-Jun N-terminal kinase; cobalt chloride
ID EXTRACELLULAR-SUPEROXIDE-DISMUTASE; ACTIVATED PROTEIN-KINASE;
   ADIPOSE-SPECIFIC PROTEIN; TYPE-2 DIABETIC-PATIENTS; OXIDATIVE STRESS;
   INSULIN-RESISTANCE; TRANSCRIPTIONAL REGULATION; ADIPONECTIN SECRETION;
   VASCULAR PROTECTION; METABOLIC SYNDROME
AB It is well known that adipose tissue is not only a passive reservoir for energy storage but also produces and secretes a variety of bioactive molecules called adipocytokines, including adiponectin and tumor necrosis factor-alpha (TNF-alpha). Recently, it has been reported that adipose tissue can suffer a chronic hypoxic condition during hypertrophy of adipocytes, and this condition leads to the dysregulation of adipocytokines. Further, hypoxic adipocytes are in an increased oxidative stress. Extracellular-superoxide dismutase (EC-SOD) is an anti-inflammatory enzyme that protects cells from reactive oxygen species (ROS) by scavenging superoxide anion. Previous reports showed that plasma EC-SOD levels in type 2 diabetes patients were significantly and inversely related to the body mass index, homeostasis model assessment-insulin resistance index; however, the mechanisms of EC-SOD and adiponectin reductions during hypoxia remain poorly understood. Here, we demonstrate that cobalt chloride (CoCl(2)), a hypoxia mimetic, decreases EC-SOD and adiponectin in 3T3-L1 adipocytes by intracellular ROS-independent, but TNF-alpha and c-jun N-terminal kinase (JNK)-dependent mechanisms. From these results, it is possible that TNF-alpha is a key regulator of the reduction of EC-SOD and adiponectin in CoCl(2)-treated 3T3-L1 adipocytes, and we speculated that the reduction of EC-SOD and adiponectin would lead to and/or promote metabolic disorders.
C1 [Kamiya, Tetsuro; Hara, Hirokazu; Adachi, Tetsuo] Gifu Pharmaceut Univ, Lab Clin Pharmaceut, Dept Biomed Pharmaceut, Gifu 5011196, Japan.
   [Kamiya, Tetsuro; Inagaki, Naoki] Gifu Univ, Field Biofunct Control, Med Informat Sci Div, United Grad Sch Drug Discovery & Med Informat Sci, Gifu, Japan.
C3 Gifu Pharmaceutical University; Gifu University
RP Kamiya, T (corresponding author), Gifu Pharmaceut Univ, Lab Clin Pharmaceut, Dept Biomed Pharmaceut, 1-25-4 Daigaku Nishi, Gifu 5011196, Japan.
EM tekamiya@gifu-pu.ac.jp
RI Kamiya, Tetsuro/AAY-7093-2021
FU Japan Society for the Promotion for Science; Grants-in-Aid for
   Scientific Research [21590169] Funding Source: KAKEN
FX This study was supported, in part, by Grant-in-aid for Scientific
   Research from the Japan Society for the Promotion for Science (to TK and
   TA).
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NR 34
TC 25
Z9 25
U1 0
U2 3
PU MANEY PUBLISHING
PI LEEDS
PA STE 1C, JOSEPHS WELL, HANOVER WALK, LEEDS LS3 1AB, W YORKS, ENGLAND
SN 1351-0002
J9 REDOX REP
JI Redox Rep.
PD JUN
PY 2010
VL 15
IS 3
BP 131
EP 137
DI 10.1179/174329210X12650506623483
PG 7
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 619VT
UT WOS:000279459100004
PM 20594416
OA Green Published
DA 2025-06-11
ER

PT J
AU Dong, C
   Hu, XZ
   Tripathi, AS
AF Dong, Cheng
   Hu, Xuzhi
   Tripathi, Alok Shiomurti
TI A brief review of vitamin D as a potential target for the regulation of
   blood glucose and inflammation in diabetes-associated periodontitis
SO MOLECULAR AND CELLULAR BIOCHEMISTRY
LA English
DT Review
DE Vitamin D; Periodontitis; Diabetes; Inflammation; Insulin
ID GINGIVAL CREVICULAR FLUID; GLYCATION END-PRODUCTS; OXIDATIVE STRESS;
   INSULIN-RESISTANCE; D-RECEPTOR; D SUPPLEMENTATION; MOLECULAR-MECHANISMS;
   METABOLIC SYNDROME; GROWTH-FACTOR; D DEFICIENCY
AB Diabetes is a metabolic disorder associated with various complications, including periodontitis. The risk of periodontitis is increased in patients with diabetes, while vitamin D deficiency is associated with both diabetes and periodontitis. Thus, there is a need to identify the molecular effects of vitamin D on the regulation of inflammation and glucose in diabetes-associated periodontitis. The Web of Science, Scopus, and PubMed databases were searched for studies of the molecular effects of vitamin D. Molecular effects were reportedly mediated by salivary secretions, interactions of advanced glycation end products (AGEs) with receptors of AGEs (RAGEs), cytokines, and oxidative stress pathways linking diabetes with periodontitis. Vitamin D supplementation attenuates inflammation in diabetes-associated periodontitis by reducing the levels of inflammatory cytokines and numbers of immune cells; it also has antibacterial effects. Vitamin D reduces cytokine levels through regulation of the extracellular signal-related kinase 1/2 and Toll-like receptor 1/2 pathways, along with the suppression of interleukin expression. Glucose homeostasis is altered in diabetes either because of reduced insulin production or decreased insulin sensitivity. These vitamin D-related alterations of glucoregulatory factors may contribute to hyperglycaemia; hyperglycaemia may also lead to alterations of glucoregulatory factors. This review discusses the pathways involved in glucose regulation and effects of vitamin D supplementation on glucose regulation. Further studies are needed to characterise the effects of vitamin D on diabetes-associated periodontitis.
C1 [Dong, Cheng; Hu, Xuzhi] Peoples Hosp Beilun Dist, Dept Stomatol, Ningbo 315800, Peoples R China.
   [Tripathi, Alok Shiomurti] Amity Univ, Amity Inst Pharm, Dept Pharmacol, Noida, UP, India.
C3 Amity University Noida
RP Hu, XZ (corresponding author), Peoples Hosp Beilun Dist, Dept Stomatol, Ningbo 315800, Peoples R China.
EM huxuzhi0314@sina.com
RI TRIPATHI, Alok/AAN-9748-2020; Hu, Xuzhi/AAM-6420-2021
OI Tripathi, Alok Shiomurti/0000-0001-7070-4933
FU People's Hospital of Beilun District, China
FX Author of this manuscript thankful to The People's Hospital of Beilun
   District, China for providing necessary support for presented
   manuscript.
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NR 143
TC 8
Z9 8
U1 0
U2 9
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0300-8177
EI 1573-4919
J9 MOL CELL BIOCHEM
JI Mol. Cell. Biochem.
PD SEP
PY 2022
VL 477
IS 9
BP 2257
EP 2268
DI 10.1007/s11010-022-04445-w
EA APR 2022
PG 12
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA 3X6PT
UT WOS:000796011500001
PM 35478388
DA 2025-06-11
ER

PT J
AU Huang, F
   Liu, AD
   Fang, HS
   Geng, XP
AF Huang, Fan
   Liu, Anding
   Fang, Haoshu
   Geng, Xiaoping
TI Serum uric acid levels in non-alcoholic steatosis patients: a
   meta-analysis
SO ASIA PACIFIC JOURNAL OF CLINICAL NUTRITION
LA English
DT Article
DE serum uric acid; non-alcoholic fatty liver disease; fatty liver; SUA;
   NAFLD
ID FATTY LIVER-DISEASE; ENDOPLASMIC-RETICULUM STRESS; METABOLIC SYNDROME;
   RISK-FACTORS; OXIDATIVE STRESS; FASTING INSULIN; SCORING SYSTEM;
   ASSOCIATION; STEATOHEPATITIS; HYPERURICEMIA
AB Background and Objectives: Experimental and observational studies suggest a role for increased uric acid in non-alcoholic fatty liver disease (NAFLD). This study aimed to systematically review the association between serum uric acid (SUA) levels and NAFLD. Method and Study Design: We used PubMed, and the EMBASE database to identify all applicable studies through November 2015. We used the weighted mean difference (WMD) to demonstrate the differences between the control and NAFLD groups in continuous data. We calculated the odds ratios (ORs) for dichotomous data using the Mantel-Haenszel method. A total of 16 observational studies were identified and used for the analysis of continuous data, and 4 studies were analyzed for dichotomous data. Results: The WMD was 52.3 (95% CI: 39.0, 65.5, p<0.00001). The pooled OR in observational studies was 2.08 (95% CI: 1.93-2.24, p<0.00001). The results were heterogeneous for the comparison of continuous data and homogeneous for the comparison of dichotomous data. The SUA cutoff value for the occurrence of NAFLD was 308, with a sensitivity of 94.12% [71.3-99.9] and specificity of 70.6% [44.0-89.7]. Conclusion: We observed a positive association between increased SUA levels and the diagnosis of NAFLD in all analyses. Our results suggest that SUA is upregulated in patients with NAFLD and might be related to the pathogenesis of NAFLD.
C1 [Huang, Fan; Geng, Xiaoping] Anhui Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Meishan Rd 81, Hefei 230032, Peoples R China.
   [Liu, Anding] Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Ctr Med Expt, Wuhan, Peoples R China.
   [Fang, Haoshu] Anhui Med Univ, Dept Pathophysiol, Hefei, Peoples R China.
C3 Anhui Medical University; Huazhong University of Science & Technology;
   Anhui Medical University
RP Geng, XP (corresponding author), Anhui Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Meishan Rd 81, Hefei 230032, Peoples R China.
EM xp_geng@163.net
RI Liu, Anding/AAU-2477-2020
FU National Natural Science Fund of China [NSFC 81401617]; Anhui Provincial
   Natural Science Foundation [1408085QH170]; Anhui Medical University
   [XJ201317]
FX This study was supported by the National Natural Science Fund of China
   (NSFC 81401617), Anhui Provincial Natural Science Foundation
   (1408085QH170) as well as Grants for Scientific Research of BSKY
   (XJ201317) from Anhui Medical University.
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NR 56
TC 10
Z9 10
U1 0
U2 12
PU H E C PRESS, HEALTHY EATING CLUB PTY LTD
PI MCKINNON
PA PO BOX 4121, MCKINNON, VIC 3204, AUSTRALIA
SN 0964-7058
EI 1440-6047
J9 ASIA PAC J CLIN NUTR
JI Asia Pac. J. Clin. Nutr.
PY 2017
VL 26
IS 2
BP 334
EP 342
DI 10.6133/apjcn.092016.04
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA EN4FX
UT WOS:000395964500020
PM 28244714
DA 2025-06-11
ER

PT J
AU Morsi, M
   Kobeissy, F
   Magdeldin, S
   Maher, A
   Aboelmagd, O
   Johar, D
   Bernstein, L
AF Morsi, Mahmoud
   Kobeissy, Firas
   Magdeldin, Sameh
   Maher, Ahmed
   Aboelmagd, Omnia
   Johar, Dina
   Bernstein, Larry
TI A shared comparison of diabetes mellitus and neurodegenerative disorders
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Article
DE diabetes mellitus; endoplasmic reticulum; mitochondria;
   neurodegeneration; stress
ID ALZHEIMERS-DISEASE; INSULIN-RESISTANCE; AUTOPHAGY
AB Diabetes mellitus (DM), one of the most prevalent metabolic diseases in the world population, is associated with a number of comorbid conditions including obesity, pancreatic endocrine changes, and renal and cardio-cerebrovascular alterations, coupled with peripheral neuropathy and neurodegenerative disease, some of these disorders are bundled into metabolic syndrome. Type 1 DM (T1DM) is an autoimmune disease that destroys the insulin-secreting islet cells. Type 2 DM (T2DM) is diabetes that is associated with an imbalance in the glucagon/insulin homeostasis that leads to the formation of amyloid deposits in the brain, pancreatic islet cells, and possibly in the kidney glomerulus. There are several layers of molecular pathologic alterations that contribute to the DM metabolic pathophysiology and its associated neuropathic manifestations. In this review, we describe the general signature metabolic features of DM and the cross-talk with neurodegeneration. We will assess the underlying molecular key players associated with DM-induced neuropathic disorders that are associated with both T1DM and T2DM. In this context, we will highlight the role of tau and amyloid protein deposits in the brain as well in the pancreatic islet cells, and possibly in the kidney glomerulus. Furthermore, we will discuss the central role of mitochondria, oxidative stress, and the unfolded protein response in mediating the DM-associated neuropathic degeneration. This study will elucidate the relationship between DM and neurodegeneration which may account for the evolution of other neurodegenerative diseases, particularly Alzheimer's disease and Parkinson's disease as discussed later.
C1 [Morsi, Mahmoud] Menoufia Univ, Fac Med, Shibin Al Kawm, Egypt.
   [Kobeissy, Firas] Amer Univ Beirut, Fac Med, Dept Biochem & Mol Genet, Beirut, Lebanon.
   [Magdeldin, Sameh] Childrens Canc Hosp, Prote & Metab Unit, Basic Res, Cairo, Egypt.
   [Magdeldin, Sameh] Suez Canal Univ, Fac Vet Med, Physiol Dept, Ismailia, Egypt.
   [Maher, Ahmed] Natl Res Ctr, Zoonot Dis Dept, Dokki, Egypt.
   [Aboelmagd, Omnia] Cairo Univ, Fac Med, Cairo, Egypt.
   [Johar, Dina] Ain Shams Univ, Fac Women Arts Sci & Educ, Dept Biochem & Nutr, Cairo, Egypt.
   [Johar, Dina] Max Rady Univ Manitoba, Rady Coll Med, Fac Hlth Sci, Dept Physiol & Pathophysiol, Winnipeg, MB, Canada.
   [Bernstein, Larry] Triplex Consulting, Northampton, MA USA.
C3 Egyptian Knowledge Bank (EKB); Menofia University; American University
   of Beirut; Children's Cancer Hospital 57357; Egyptian Knowledge Bank
   (EKB); Suez Canal University; Egyptian Knowledge Bank (EKB); National
   Research Centre (NRC); Egyptian Knowledge Bank (EKB); Cairo University;
   Egyptian Knowledge Bank (EKB); Ain Shams University; University of
   Manitoba
RP Johar, D (corresponding author), Univ Manitoba, Rady Coll Med, Max Rady Fac Hlth Sci, Dept Physiol & Pathophysiol, Winnipeg, MB R3E 1Y7, Canada.
EM dinajohar@gmail.com
RI Johar, Dina/JTV-7123-2023; AboElmagd, Ahmed/KGL-5479-2024; morsi,
   mahmoud/Y-8086-2019; Kobeissy, Firas/E-7042-2017
OI Morsi, Mahmoud/0000-0002-6621-0751; Kobeissy, Firas/0000-0002-5008-6944;
   Maher, Ahmed/0000-0002-7572-9053; Magdeldin, sameh/0000-0002-7507-9935;
   morsi, mahmoud/0000-0001-6825-7361; JOHAR, DINA/0000-0003-0866-9959
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NR 24
TC 16
Z9 16
U1 1
U2 14
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0730-2312
EI 1097-4644
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PD SEP
PY 2019
VL 120
IS 9
BP 14318
EP 14325
DI 10.1002/jcb.28094
PG 8
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA IK7WN
UT WOS:000476804200012
PM 30565720
DA 2025-06-11
ER

PT J
AU Cheng, AS
   Cheng, YH
   Chiou, CH
   Chang, TL
AF Cheng, An-Sheng
   Cheng, Yu-Hsiang
   Chiou, Chiu-Hsia
   Chang, Tsu-Liang
TI Resveratrol Upregulates Nrf2 Expression To Attenuate
   Methylglyoxal-Induced Insulin Resistance in Hep G2 Cells
SO JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
LA English
DT Article
DE Methylglyoxal; insulin resistance; resveratrol; nuclear factor erythroid
   2-related factor 2; heme oxygenase-1; glyoxalase
ID HEME OXYGENASE-1 EXPRESSION; GLUCOSE-SENSING APPARATUS; OXIDATIVE
   STRESS; MOLECULAR-MECHANISMS; METABOLIC SYNDROME; ACTIVATING SIRT1; FAT
   DIET; ANTIOXIDANT; LIVER; GLUCOKINASE
AB Oxidative stress can result in insulin resistance, a primary cause of type-2 diabetes. Methylglyoxal (MG), a highly reactive dicarbonyl metabolite generated during glucose metabolism, has also been confirmed to cause pancreatic injury and induce inflammation, thereby resulting in insulin resistance. Recently, resveratrol has been reported to exert antioxidant properties, protecting cells from the generation of reactive oxygen species (ROS). The aim of this study was to evaluate resveratrol activation of nuclear factor erythroid 2-related factor 2 (Nrf2) to attenuate MG-induced insulin resistance in Hep G2 cells. Therefore, the molecular signaling events affecting resveratrol-mediated heme oxygenase-1 (HO-1) and glyoxalase expression levels were further investigated in this study. Our findings indicated that resveratrol activated the extracellular signal-regulated kinase (ERK) pathway but not the p38 or c-Jun N-terminal kinase (INK) pathways, subsequently leading to Nrf2 nuclear translocation and elevation of HO-1 and glyoxalase expression levels. Moreover, resveratrol significantly elevated glucose uptake and protected against MG-induced insulin resistance in Hep G2 cells. In contrast, depletion of Nrf2 by small interfering RNA (si-RNA) resulted in the abrogation of HO-1 and glyoxalase expression in the MG-treated resveratrol group in Hep G2 cells. Administration of an appropriate chemopreventive agent, such as resveratrol, may be an alternative strategy for protecting against MG-induced diabetes.
C1 [Cheng, An-Sheng; Chang, Tsu-Liang] Natl Taiwan Univ, Dept Hort & Landscape Architecture, Taipei 10617, Taiwan.
   [Cheng, Yu-Hsiang] Univ Auckland, Dept Sci, Auckland 1142, New Zealand.
   [Chiou, Chiu-Hsia] Natl Pingtung Univ Sci & Technol, Dept Food Sci, Neipu 912, Pingtung, Taiwan.
C3 National Taiwan University; University of Auckland; National Pingtung
   University Science & Technology
RP Chang, TL (corresponding author), Natl Taiwan Univ, Dept Hort & Landscape Architecture, Taipei 10617, Taiwan.
EM ghouse@ntu.edu.tw
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NR 62
TC 128
Z9 144
U1 0
U2 39
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0021-8561
EI 1520-5118
J9 J AGR FOOD CHEM
JI J. Agric. Food Chem.
PD SEP 12
PY 2012
VL 60
IS 36
SI SI
BP 9180
EP 9187
DI 10.1021/jf302831d
PG 8
WC Agriculture, Multidisciplinary; Chemistry, Applied; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture; Chemistry; Food Science & Technology
GA 002YL
UT WOS:000308574900051
PM 22917016
DA 2025-06-11
ER

PT J
AU Ji, E
   Weickert, CS
   Purves-Tyson, T
   White, C
   Handelsman, DJ
   Desai, R
   O'Donnell, M
   Liu, D
   Galletly, C
   Lenroot, R
   Weickert, TW
AF Ji, Ellen
   Weickert, Cynthia Shannon
   Purves-Tyson, Tertia
   White, Christopher
   Handelsman, David J.
   Desai, Reena
   O'Donnell, Maryanne
   Liu, Dennis
   Galletly, Cherrie
   Lenroot, Rhoshel
   Weickert, Thomas W.
TI Cortisol-dehydroepiandrosterone ratios are inversely associated with
   hippocampal and prefrontal brain volume in schizophrenia
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE Schizophrenia; Dehydroepiandrosterone; Cortisol; Hippocampus;
   Dorsolateral prefrontal cortex, Hypothalamic-pituitary-adrenal axis
ID PROLONGED GLUCOCORTICOID EXPOSURE; METABOLIC SYNDROME; OXIDATIVE STRESS;
   NEUROACTIVE STEROIDS; CEREBROSPINAL-FLUID; SOCIAL STRESS; DHEA SULFATE;
   1ST EPISODE; SERUM; CORTEX
AB While high levels of glucocorticoids are generally neuro-damaging, a related adrenal steroid, dehydroepiandrosterone (DHEA), has anti-glucocorticoid and neuroprotective properties. Previous work has shown increased circulating levels of DHEA and abnormal cortisol/DHEA ratios in people with schizophrenia, however reports are limited and their relationship to neuropathology is unclear. We performed the largest study to date to compare levels of serum DHEA and cortisol/DHEA ratios in people with schizophrenia and healthy controls, and investigated the extent to which cortisol/DHEA ratios predict brain volume. Serum cortisol and DHEA were assayed in 94 people with schizophrenia and 81 healthy controls. T1-weighted high-resolution anatomical scans were obtained using a 3 T Achieva scanner on a subset of 59 people with schizophrenia and 60 healthy controls. Imaging data were preprocessed and analyzed using SPM12. People with schizophrenia had significantly increased serum DHEA levels (p = 0.002), decreased cortisol/DHEA ratios (p = 0.02) and no difference in cortisol levels compared to healthy controls. Cortisol/DHEA ratios were inversely correlated with hippocampal (r =-0.33 p = 0.01) and dorsolateral prefrontal cortex (r =-0.30, p = 0.02) volumes in patients. Our findings suggest that the cortisol/ DHEA ratio may be a molecular blood signature of hippocampal and cortical damage. These results further implicate the role of DHEA and hypothalamic-pituitary-adrenal axis dysfunction in the pathophysiology of schizophrenia.
C1 [Ji, Ellen] Univ Zurich, Hosp Psychiat, Lenggstr 31, CH-8032 Zurich, Switzerland.
   [Ji, Ellen; Weickert, Cynthia Shannon; Purves-Tyson, Tertia; Weickert, Thomas W.] Neurosci Res Australia, Schizophrenia Res, Sydney, NSW 2031, Australia.
   [Ji, Ellen; Weickert, Cynthia Shannon; Purves-Tyson, Tertia; O'Donnell, Maryanne; Lenroot, Rhoshel; Weickert, Thomas W.] Univ New South Wales, Sch Psychiat, Sydney, NSW 2052, Australia.
   [Weickert, Cynthia Shannon; Weickert, Thomas W.] Upstate Med Univ, Dept Neurosci & Physiol, Syracuse, NY 13210 USA.
   [White, Christopher] Prince Wales Hosp, Dept Endocrinol, Randwick, NSW 2031, Australia.
   [Handelsman, David J.; Desai, Reena] Univ Sydney, Concord Hosp, ANZAC Res Inst, Sydney, NSW, Australia.
   [Liu, Dennis; Galletly, Cherrie] Univ Adelaide, Sch Med, Discipline Psychiat, Adelaide, SA, Australia.
   [Liu, Dennis; Galletly, Cherrie] Northern Adelaide Local Hlth Network, Adelaide, SA, Australia.
   [Galletly, Cherrie] Ramsay Hlth Care SA Mental Hlth Serv, Adelaide, SA, Australia.
C3 University of Zurich; Neuroscience Research Australia; University of New
   South Wales Sydney; State University of New York (SUNY) System; State
   University of New York (SUNY) Upstate Medical Center; University of New
   South Wales Sydney; Prince of Wales Hospital (POWH); Concord
   Repatriation General Hospital; University of Sydney; ANZAC Research
   Institute; University of Adelaide; Ramsay Health Care Limited
RP Ji, E (corresponding author), Univ Zurich, Hosp Psychiat, Lenggstr 31, CH-8032 Zurich, Switzerland.
EM ellen.ji@uzh.ch
RI White, Christopher/K-8262-2019; Purves-Tyson, Tertia/KBP-9654-2024;
   Handelsman, David/AAR-9580-2021; Weickert, Thomas/AFS-7669-2022;
   Weickert, Cynthia/G-3171-2011; Purves-Tyson, Tertia/C-9799-2011;
   Weickert, Thomas/D-3827-2011
OI Ji, Ellen/0000-0003-1527-8868; Handelsman, David/0000-0002-4200-7476;
   Purves-Tyson, Tertia/0000-0003-2401-4266; Shannon Weickert,
   Cynthia/0000-0002-4560-0259; Weickert, Thomas/0000-0002-6408-718X
FU National Health and Medical Research Council (NHMRC) of Australia
   [568807]; NSW Ministry of Health, Office of Health and Medical Research;
   Pratt Foundation; Ramsay Health Care; Viertel Charitable Foundation;
   National Health and Medical Research Council (Australia) Principal
   Research Fellowship (PRF) [1117079]
FX This work was supported by grant 568807 from the National Health and
   Medical Research Council (NHMRC) of Australia, the NSW Ministry of
   Health, Office of Health and Medical Research, the Pratt Foundation,
   Ramsay Health Care and the Viertel Charitable Foundation. CSW is a
   recipient of a National Health and Medical Research Council (Australia)
   Principal Research Fellowship (PRF) (#1117079). The authors declare no
   conflict of interest in relation to this work.
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NR 70
TC 11
Z9 12
U1 1
U2 4
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
EI 1873-3360
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD JAN
PY 2021
VL 123
AR 104916
DI 10.1016/j.psyneuen.2020.104916
PG 8
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA PB7OT
UT WOS:000596506700015
PM 33169678
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Nicolai, E
   Wrzesien, M
AF Nicolai, Eleonora
   Wrzesien, Malgorzata
TI Risk factors for eye lens opacity in nuclear medicine workers - An
   overview
SO RADIATION PHYSICS AND CHEMISTRY
LA English
DT Article
DE Risk factor; Radiation protection; Nuclear medicine; Nutrients; Eye
   lens; Caratogenesis
ID AGE-RELATED CATARACT; RADIATION-INDUCED CATARACTS; ALDOSE REDUCTASE
   ENZYME; NEURONAL CELL-DEATH; IONIZING-RADIATION; METABOLIC SYNDROME;
   OXIDATIVE STRESS; DOSE LIMIT; PROSPECTIVE COHORT; VITAMIN-C
AB Workers occupationally exposed to ionizing radiation, including nuclear medicine workers, are one of the groups at higher risk of a radiation cataract. Reducing the lens dose limit from 150 mSv/year to 20 mSv (averaged over defined periods of 5 yrs, or 50 mSv in 1 yr) makes other risk factors less obvious. The presented work is a review of the literature not only in the scope of the most obvious risk factor in this occupational group - ionizing radiation, with special attention given to issues specific to nuclear medicine (e.g. the variety of radionuclides or manual performing of procedures), as well as the difficulties related to the routine monitoring of eye lens exposure. Moreover, the paper presents several other risk factors that may play a key role in modulating damage to the eye lens. These include age, exposure to UV radiation, oxidative stress, genetic factors and dietary nutrient intake. An overview of all known molecular and biophysical mechanisms that imply the modulation of the cataract-related mechanism most often focus on radiation protection, has been given. The prepared review is the basis for the possibility of developing new studies aimed to introduce new protocols based on the intake of specific nutrients that could reduce the effects of the dose absorbed by the lens and, consequently, reduce the onset of cataracts in an employee involved in nuclear medicine practices.
C1 [Nicolai, Eleonora] Univ Roma Tor Vergata, Dept Expt Med, Via Montpellier 1, I-00133 Rome, Italy.
   [Wrzesien, Malgorzata] Univ Lodz, Facil Phys & Appl Informat, Dept Nucl Phys & Radiat Safety, Pomorska 149-153, PL-90236 Lodz, Poland.
C3 University of Rome Tor Vergata; University of Lodz
RP Wrzesien, M (corresponding author), Univ Lodz, Facil Phys & Appl Informat, Dept Nucl Phys & Radiat Safety, Pomorska 149-153, PL-90236 Lodz, Poland.
EM nicolai@med.uniroma2.it; malgorzata.wrzesien@uni.lodz.pl
RI Nicolai, Eleonora/AAR-4554-2020
OI Nicolai, Eleonora/0000-0003-1415-9808
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NR 136
TC 1
Z9 1
U1 1
U2 6
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0969-806X
EI 1879-0895
J9 RADIAT PHYS CHEM
JI Radiat. Phys. Chem.
PD JAN
PY 2024
VL 214
AR 111260
DI 10.1016/j.radphyschem.2023.111260
EA SEP 2023
PG 10
WC Chemistry, Physical; Nuclear Science & Technology; Physics, Atomic,
   Molecular & Chemical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Nuclear Science & Technology; Physics
GA S7NN6
UT WOS:001073002000001
OA hybrid
DA 2025-06-11
ER

PT J
AU Yamagishi, S
   Matsui, T
AF Yamagishi, Sho-ichi
   Matsui, Takanori
TI Pigment Epithelium-Derived Factor: A Novel Therapeutic Target for
   Cardiometabolic Diseases and Related Complications
SO CURRENT MEDICINAL CHEMISTRY
LA English
DT Review
DE Cardiovascular disease; inflammation; metabolic disorder; oxidative
   stress; PEDF; retinopathy; diabetic nephropathy
ID GLYCATION END-PRODUCTS; ENDOTHELIAL-GROWTH-FACTOR; C-REACTIVE PROTEIN;
   FACTOR PEDF BLOCKS; HEPATIC INSULIN-RESISTANCE; IMPROVES
   CARDIAC-FUNCTION; FACTOR VEGF EXPRESSION; RETINAL MULLER CELLS; FATTY
   LIVER-DISEASE; SERUM-LEVELS
AB Pigment epithelium-derived factor (PEDF) is a glycoprotein that belongs to the superfamily of serine protease inhibitors, serpins. It was first identified as a neuronal differentiating factor secreted by human retinal pigment epithelial cells, and then found to be the most potent inhibitor of pathological angiogenesis in mammalian eyes. Recently, PEDF has been shown not only to suppress oxidative stress and inflammatory reactions in vascular wall cells, T cells and macrophages, and adipocytes, but also to exert antithrombotic and anti-fibrotic properties, thereby protecting against the development and progression of various cardiometabolic diseases and related complications. Furthermore, accumulating evidence has suggested that circulating PEDF levels may be a biomarker of severity and prognosis of these devastating disorders. Number of subjects with visceral obesity and insulin resistance is increasing, and the metabolic syndrome and its related complications, such as diabetes, nonalcoholic fatty liver disease/non-alcoholic steatohepatits, and atherosclerotic cardiovascular disease are a growing health challenge. Therefore, in this study, we review the pathophysiological role of PEDF in obesity and metabolic disorders, cardiovascular disease, diabetic eye and kidney complications, liver diseases, and reproductive system disorders, and discuss the potential clinical utility of modulating the expression and actions of PEDF for preventing these cardiometabolic disorders. We also refer to the clinical value of PEDF as a biomarker in cardiometabolic complications.
C1 [Yamagishi, Sho-ichi; Matsui, Takanori] Kurume Univ, Sch Med, Dept Pathophysiol & Therapeut Diabet Vasc Complic, Kurume, Fukuoka 8300011, Japan.
C3 Kurume University
RP Yamagishi, S (corresponding author), Kurume Univ, Sch Med, Dept Pathophysiol & Therapeut Diabet Vasc Complic, Kurume, Fukuoka 8300011, Japan.
EM shoichi@med.kurume-u.ac.jp
OI Matsui, Takanori/0000-0001-9506-7571
FU Ministry of Education, Culture, Sports, Science and Technology, Japan
   [25293127]; Grants-in-Aid for Scientific Research [25293127] Funding
   Source: KAKEN
FX This study was supported in part by Grants-in-Aid for Scientific
   Research (B) (Grant Number 25293127) from the Ministry of Education,
   Culture, Sports, Science and Technology, Japan (to S.Y.).
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NR 225
TC 23
Z9 24
U1 1
U2 15
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 0929-8673
EI 1875-533X
J9 CURR MED CHEM
JI Curr. Med. Chem.
PY 2018
VL 25
IS 13
BP 1480
EP 1500
DI 10.2174/0929867324666170608103140
PG 21
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Pharmacology &
   Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
GA GF8SV
UT WOS:000432244300002
PM 28595552
DA 2025-06-11
ER

PT J
AU Schloms, L
   Smith, C
   Storbeck, KH
   Marnewick, JL
   Swart, P
   Swart, AC
AF Schloms, Lindie
   Smith, Carine
   Storbeck, Karl-Heinz
   Marnewick, Jeanine L.
   Swart, Pieter
   Swart, Amanda C.
TI Rooibos influences glucocorticoid levels and steroid ratios in vivo and
   in vitro: A natural approach in the management of stress and metabolic
   disorders?
SO MOLECULAR NUTRITION & FOOD RESEARCH
LA English
DT Article
DE Adrenal H295R cells; Cytochrome P450; Functional food; Metabolic
   syndrome; Rooibos tea polyphenol flavonoids
ID ASPALATHUS-LINEARIS; FLAVONOIDS; CORTISOL; INHIBITION; PRODUCTS;
   DISEASE; ASSAY
AB ScopeTo determine the effect of Rooibos (Aspalathus linearis) on glucocorticoid biosynthesis and inactivation in vivo and in vitro.
   Methods and resultsUltra-performance liquid chromatography/tandem mass spectrometry (UPLC-MS/MS) analyses of in vivo studies showed that human Rooibos consumption increased cortisone plasma levels in males (p = 0.0465) and reduced cortisol:cortisone ratios in males and females (p = 0.0486) at risk for cardiovascular disease. In rats, corticosterone (CORT) (p = 0.0275) and deoxycorticosterone (p = 0.0298) levels as well as the CORT:testosterone ratio (p = 0.0009) decreased following Rooibos consumption. The inactivation of cortisol was investigated in vitro by expressing 11-hydroxysteroid dehydrogenase type 1 (11HSD1) and type 2 (11HSD2) in CHO-K1 cells. Rooibos inhibited 11HSD1, which resulted in a significant reduction in the cortisol:cortisone ratio (p < 0.01). No significant effect was detected on 11HSD2. In vitro studies in adrenal H295R cells showed that Rooibos and rutin, one of the more stable flavonoid compounds present in Rooibos, significantly reduced the levels of cortisol and CORT in cells stimulated with forskolin to mimic a stress response.
   ConclusionIn vivo studies demonstrate that Rooibos significantly decreased glucocorticoid levels in rats and steroid metabolite ratios linked to metabolic disorderscortisol:cortisone in humans and CORT:testosterone in rats. Results obtained at cellular level elucidate possible mechanisms by which these effects were achieved.
C1 [Schloms, Lindie; Storbeck, Karl-Heinz; Swart, Pieter; Swart, Amanda C.] Univ Stellenbosch, Dept Biochem, ZA-7600 Stellenbosch, South Africa.
   [Smith, Carine] Univ Stellenbosch, Dept Physiol Sci, ZA-7600 Stellenbosch, South Africa.
   [Marnewick, Jeanine L.] Cape Peninsula Univ Technol, Oxidat Stress Res Ctr, Fac Hlth & Wellness Sci, Bellville, South Africa.
C3 Stellenbosch University; Stellenbosch University; Cape Peninsula
   University of Technology
RP Swart, AC (corresponding author), Univ Stellenbosch, Dept Biochem, Private Bag X1, ZA-7602 Matieland, South Africa.
EM acswart@sun.ac.za
RI Storbeck, Karl/AAF-5126-2020; TECHNOLOGY, CAPE PENINSULA
   UNIVERSITY/L-3761-2019; Smith, Carine/D-7159-2012; Swart, Amanda
   C./O-5939-2017; Swart, Pieter/J-3856-2015
OI Marnewick, Jeanine L/0000-0002-1819-1699; Storbeck,
   Karl-Heinz/0000-0003-1669-6383; Smith, Carine/0000-0001-5924-9204;
   Swart, Amanda C./0000-0001-7529-8989; Swart, Pieter/0000-0001-8610-4799
FU South African Rooibos Council; Medical Research Council, South Africa;
   National Research Foundation/THRIP
FX The authors wish to acknowledge the financial support of the South
   African Rooibos Council, the Medical Research Council, South Africa, and
   the National Research Foundation/THRIP. The authors thank Dr. Lize van
   der Merwe for comprehensive statistical analyses and subsequent
   contributions in the preparation of the manuscript. The authors also
   wish to acknowledge Dr. Christiaan Malherbe and Professor Lizette
   Joubert for Rooibos analyses and Mr. Marthinus Janse van Vuuren for his
   dedicated technical assistance during the weeks in which the rat study
   was undertaken. The H295R cell line was a kind gift from Professor
   William E. Rainey.
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NR 34
TC 20
Z9 21
U1 2
U2 28
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1613-4125
EI 1613-4133
J9 MOL NUTR FOOD RES
JI Mol. Nutr. Food Res.
PD MAR
PY 2014
VL 58
IS 3
BP 537
EP 549
DI 10.1002/mnfr.201300463
PG 13
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA AC2NZ
UT WOS:000332339600011
PM 24022885
DA 2025-06-11
ER

PT J
AU El-Kersh, DM
   Kotob, SE
   Ammar, NM
   Mohawed, OAM
   Ahmed, HH
   Farag, MA
AF El-Kersh, Dina M.
   Kotob, Soheir E.
   Ammar, Naglaa M.
   Mohawed, Ola A. M.
   Ahmed, Hanaa H.
   Farag, Mohamed A.
TI Unravelling the anti-inflammatory and antioxidant effects of
   standardized green and black caffeinated coffee, tea, and their mixtures
   in an obese male rat model: Insights from biochemical, metabolomic, and
   histopathological analyses
SO FOOD AND CHEMICAL TOXICOLOGY
LA English
DT Article
DE Coffee and tea; Obesity; Biomarkers; Metabolomics; Serum; GC-MS
ID HEPATIC INSULIN-RESISTANCE; HIGH-FRUCTOSE DIET; CHAIN FATTY-ACIDS;
   OXIDATIVE STRESS; ADIPOSE-TISSUE; EPIGALLOCATECHIN GALLATE; CHLOROGENIC
   ACIDS; LIVER; INFLAMMATION; ANTIOBESITY
AB Obesity is one of the major metabolic syndrome risk factors upon which altered metabolic pathways follow. This study aimed to discern altered metabolic pathways associated with obesity and to pinpoint metabolite biomarkers in serum of obese rats fed on high fructose diet using metabolomics. Further, the effect of standardized green versus black caffeinated aqueous extracts (tea and coffee) in controlling obesity and its comorbidities through monitoring relevant serum biomarkers viz. Leptin, adiponectin, spexin, malondialdehyde, total antioxidant capacity. Liver tissue oxidative stress (catalase, super oxide dismutase and glutathione) and inflammation (IL-1 & beta; and IL-6) markers were assessed for green coffee and its mixture with green tea. Results revealed improvement of all parameters upon treatments with more prominence for those treated with green caffeinated extract (coffee and tea) especially in mixture. Upon comparing with obese rat group, the green mixture of coffee and tea exhibited anti-hyperlipidemic action through lowering serum triglycerides by 35.0% and elevating high density lipoprotein by 71.0%. Black tea was likewise effective in lowering serum cholesterol and low density lipoprotein by 28.0 and 50.6%, respectively. GC-MS- based metabolomics of rat serum led to the identification of 34 metabolites with obese rat serum enriched in fatty acids (oleamide).
C1 [El-Kersh, Dina M.] British Univ Egypt, Fac Pharm, Dept Pharmacognosy, Cairo 11837, Egypt.
   [Kotob, Soheir E.; Mohawed, Ola A. M.; Ahmed, Hanaa H.] Med Res & Clin Studies Inst, Natl Res Ctr, Hormones Dept, Dokki, Giza, Egypt.
   [Ammar, Naglaa M.] Natl Res Ctr, Pharmaceut & Drug Ind Res Inst, Therapeut Chem Dept, Dokki 12622, Giza, Egypt.
   [Farag, Mohamed A.] Cairo Univ, Coll Pharm, Pharmacognosy Dept, Kasr El Aini St, Cairo 11562, Egypt.
C3 Egyptian Knowledge Bank (EKB); British University in Egypt; Egyptian
   Knowledge Bank (EKB); National Research Centre (NRC); Egyptian Knowledge
   Bank (EKB); National Research Centre (NRC); Egyptian Knowledge Bank
   (EKB); Cairo University
RP El-Kersh, DM (corresponding author), British Univ Egypt, Fac Pharm, Dept Pharmacognosy, Cairo 11837, Egypt.; Farag, MA (corresponding author), Cairo Univ, Coll Pharm, Pharmacognosy Dept, Kasr El Aini St, Cairo 11562, Egypt.
EM dina.elkersh@bue.edu.eg; Mohamed.farag@pharma.cu.edu.eg
RI Kotob, Soheir/P-3341-2015; Ammar, Naglaa/ACL-3524-2022; Elseedi,
   Hesham/KGK-5692-2024
FU British University in Egypt
FX The authors would like to thank The British University in Egypt "Young
   Investigator Research Grants (YIRG)" for their financial support for
   this project entitled "A metabolomics approach of some functional foods
   in obesity management". Dina M. El-Kersh would like to thanks Prof.
   Mohamed M. Elmazar, Pharmacology department and Dean Faculty of
   Pharmacy, The British University in Egypt for his generous support in
   the statistical analysis section.
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NR 109
TC 4
Z9 4
U1 2
U2 20
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0278-6915
EI 1873-6351
J9 FOOD CHEM TOXICOL
JI Food Chem. Toxicol.
PD SEP
PY 2023
VL 179
AR 113971
DI 10.1016/j.fct.2023.113971
EA JUL 2023
PG 17
WC Food Science & Technology; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Toxicology
GA P6NT7
UT WOS:001051831100001
PM 37506863
DA 2025-06-11
ER

PT J
AU Tao, SS
   Yang, YJ
   Li, JZ
   Wang, HY
   Ma, Y
AF Tao, Shasha
   Yang, Youjing
   Li, Jianzhong
   Wang, Hongyan
   Ma, Yu
TI Bixin Attenuates High-Fat Diet-Caused Liver Steatosis and Inflammatory
   Injury through Nrf2/PPARα Signals
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Article
AB Nonalcoholic fatty liver disease is the most common liver disease worldwide. Hepatic steatosis and oxidative stress are the main characteristics of NAFLD (nonalcoholic fatty liver disease), which also affect its prognosis. Bixin acts as novel Nrf2 (NF-E2 p45-related factor 2) activator with the cytoprotection against oxidative stress and inflammation; this study mainly focused on the mechanism of Nrf2 activation by bixin and explored its potential feasibilities in long-term high-fat diet- (HFD-) caused hepatic steatosis and inflammatory response in vitro and in vivo. Bixin was found to activate Nrf2 signals by the modification of critical Keap1 (Kelch-like ECH-associated protein 1) cystine and competitive interaction with Keap1 with upregulating P62 mRNA and protein expression. In human liver cells exposed to FFA (free fatty acid), bixin displayed a pronounced cytoprotective activity with upregulation of Nrf2-mediated gene expression, such as PPAR alpha and its targets related with fatty acid oxidation. In HFD-fed mice, systemic administration of bixin attenuated lipid accumulation, decreased oxidant inflammatory damage in the liver, and reduced circulating lipid levels through Nrf2. Different from most of other established inducers, bixin activated Nrf2 signals through two different mechanisms with safe administration for protection of oxidant inflammatory damage and attenuation of lipid accumulation in the in vivo long-term HFD-fed mice. Bixin represents a prototype Nrf2 activator that displays cytoprotective activity upon system administration targeting hepatic steatosis and oxidant inflammation originating from long-term HFD-fed mice. And bixin-based Nrf2-directed systemic intervention may also provide therapeutic benefit in protecting other organs in the process of metabolic syndrome.
C1 [Tao, Shasha; Wang, Hongyan; Ma, Yu] Chongqing Univ Cent Hosp & Chongqing Emergency Me, 1 Jiankang Rd, Chongqing 400014, Peoples R China.
   [Tao, Shasha; Yang, Youjing] Soochow Univ, Coll Med, Sch Publ Hlth, 199 Renai Rd, Suzhou 215123, Peoples R China.
   [Li, Jianzhong] Soochow Univ, Dept Nephrol, Affiliated Hosp 1, Suzhou 215006, Jiangsu, Peoples R China.
C3 Soochow University - China; Soochow University - China
RP Tao, SS (corresponding author), Chongqing Univ Cent Hosp & Chongqing Emergency Me, 1 Jiankang Rd, Chongqing 400014, Peoples R China.; Tao, SS (corresponding author), Soochow Univ, Coll Med, Sch Publ Hlth, 199 Renai Rd, Suzhou 215123, Peoples R China.
EM taoqishu619@126.com; 18783921296@163.com; 358278982@qq.com;
   1048989208@qq.com; yr7964@sina.com
RI Jianzhong, Li/AFT-9520-2022; , Shasha Tao/HJJ-0609-2023
OI , Shasha Tao/0000-0002-6765-3829
FU National Natural Science Foundation of China [81703205]; Foundation from
   Chongqing Yuzhong District Science and Technology Bureau [201930];
   Priority Academic Program Development of Jiangsu Higher Education
   Institutions (PAPD); Natural Science Foundation of Chongqing
   [cstc2020jcyj-msxm3187]
FX The grants that supported our study are as follows: the National Natural
   Science Foundation of China (81703205), the Foundation from Chongqing
   Yuzhong District Science and Technology Bureau (201930), a project
   funded by the Priority Academic Program Development of Jiangsu Higher
   Education Institutions (PAPD), and the Natural Science Foundation of
   Chongqing (cstc2020jcyj-msxm3187).
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NR 46
TC 16
Z9 17
U1 2
U2 16
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PD FEB 2
PY 2021
VL 2021
AR 6610124
DI 10.1155/2021/6610124
PG 17
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA QK1RI
UT WOS:000620158100002
PM 33603948
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Taguchi, K
   Hamamoto, S
   Okada, A
   Unno, R
   Kamisawa, H
   Naiki, T
   Ando, R
   Mizuno, K
   Kawai, N
   Tozawa, K
   Kohri, K
   Yasui, T
AF Taguchi, Kazumi
   Hamamoto, Shuzo
   Okada, Atsushi
   Unno, Rei
   Kamisawa, Hideyuki
   Naiki, Taku
   Ando, Ryosuke
   Mizuno, Kentaro
   Kawai, Noriyasu
   Tozawa, Keiichi
   Kohri, Kenjiro
   Yasui, Takahiro
TI Genome-Wide Gene Expression Profiling of Randall's Plaques in Calcium
   Oxalate Stone Formers
SO JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
LA English
DT Article
ID KIDNEY-STONES; BASEMENT-MEMBRANES; METABOLIC SYNDROME; NEPHROLITHIASIS;
   ASSOCIATION; UROLITHIASIS; GROWTH; PATHOGENESIS; PREVALENCE; TRENDS
AB Randall plaques (RPs) can contribute to the formation of idiopathic calcium oxalate (CaOx) kidney stones; however, genes related to RP formation have not been identified. We previously reported the potential therapeutic role of osteopontin (OPN) and macrophages in CaOx kidney stone formation, discovered using genome-recombined mice and genome-wide analyses. Here, to characterize the genetic pathogenesis of RPs, we used microarrays and immunohistology to compare gene expression among renal papillary RP and non-RP tissues of 23 CaOx stone formers (SFs) (age- and sex-matched) and normal papillary tissue of seven controls. Transmission electron microscopy showed OPN and collagen expression inside and around RPs, respectively. Cluster analysis revealed that the papillary gene expression of CaOx SFs differed significantly from that of controls. Disease and function analysis of gene expression revealed activation of cellular hyperpolarization, reproductive development, and molecular transport in papillary tissue from RPs and non-RP regions of CaOx SFs. Compared with non-RP tissue, RP tissue showed upregulation (>2-fold) of LCN2, IL11, PTGS1, GPX3, and MMD and downregulation (0.5-fold) of SLC12A1 and NALCN (P<0.01). In network and toxicity analyses, these genes associated with activated mitogenactivated protein kinase, the Akt/phosphatidylinositol 3-kinase pathway, and proinflammatory cytokines that cause renal injury and oxidative stress. Additionally, expression of proinflammatory cytokines, numbers of immune cells, and cellular apoptosis increased in RP tissue. This study establishes an association between genes related to renal dysfunction, proinflammation, oxidative stress, and ion transport and RP development in CaOx SFs.
C1 [Taguchi, Kazumi; Hamamoto, Shuzo; Okada, Atsushi; Unno, Rei; Kamisawa, Hideyuki; Naiki, Taku; Ando, Ryosuke; Mizuno, Kentaro; Kawai, Noriyasu; Tozawa, Keiichi; Kohri, Kenjiro; Yasui, Takahiro] Nagoya City Univ, Grad Sch Med Sci, Dept Nephrourol, Nagoya, Aichi, Japan.
   [Taguchi, Kazumi; Kamisawa, Hideyuki] Kojunkai Daido Hosp, Social Med Corp, Daido Clin, Dept Urol, Nagoya, Aichi, Japan.
C3 Nagoya City University
RP Okada, A (corresponding author), Nagoya City Univ, Grad Sch Med Sci, Dept Nephrourol, Mizuho Ku, 1 Kawasumi,Mizuho Cho, Nagoya, Aichi 4678601, Japan.
EM a-okada@med.nagoya-cu.ac.jp
RI YASUI, Takahiro/E-6401-2018; Naiki, Taku/AEC-7521-2022; Mizuno,
   Kentaro/H-8950-2019; Taguchi, Kazumi/AFU-4486-2022
OI Yasui, Takahiro/0000-0003-2197-2477; Naiki, Taku/0000-0002-7638-6048;
   Taguchi, Kazumi/0000-0002-3092-5114; Mizuno, Kentaro/0000-0002-9624-2009
FU Ministry of Education, Culture, Sports, Science and Technology, Japan
   [15H04976, 15K10627, 25861443]; Japanese Society on Urolithiasis
   Research; Japanese Urological Association; Takeda Science Foundation;
   Medical Research Encouragement Prize of the Japan Medical Association;
   Grants-in-Aid for Scientific Research [25861443, 16K11054, 15H04976,
   15K10627, 15K20103, 16K15692, 15K10628] Funding Source: KAKEN
FX We thank Hiroshi Takase from the Medical Sciences Core Laboratory at
   Nagoya City University Graduate School for the assistance with TEM and
   EDX analyses, and Dr. Takeshi Sakakura from the Department of Urology,
   Konan Kosei Hospital and Dr. Yutaka Iwase from the Department of
   Urology, Toyota Kosei Hospital for obtaining approval from the ethical
   committees of their hospitals. This work was supported in part by
   Grants-in-Aid for Scientific Research from the Ministry of Education,
   Culture, Sports, Science and Technology, Japan (Nos. 15H04976, 15K10627,
   and 25861443), the first research grant of the Japanese Society on
   Urolithiasis Research, the eighth Young Researcher Promotion Grant of
   the Japanese Urological Association, a medical research grant of the
   Takeda Science Foundation, and the Medical Research Encouragement Prize
   of the Japan Medical Association.
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NR 51
TC 100
Z9 111
U1 1
U2 14
PU AMER SOC NEPHROLOGY
PI WASHINGTON
PA 1725 I ST, NW STE 510, WASHINGTON, DC 20006 USA
SN 1046-6673
EI 1533-3450
J9 J AM SOC NEPHROL
JI J. Am. Soc. Nephrol.
PD JAN
PY 2017
VL 28
IS 1
BP 333
EP 347
DI 10.1681/ASN.2015111271
PG 15
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA EH3CW
UT WOS:000391647700034
PM 27297950
OA Green Published
DA 2025-06-11
ER

PT J
AU Imhoff, BR
   Hansen, JM
AF Imhoff, Barry R.
   Hansen, Jason M.
TI Extracellular redox environments regulate adipocyte differentiation
SO DIFFERENTIATION
LA English
DT Article
DE Redox; Extracellular; Cysteine; Adipogenesis; Oxidative stress
ID OXIDATIVE STRESS; METABOLIC SYNDROME; LIPID-PEROXIDATION; HUMAN PLASMA;
   WEIGHT-LOSS; GLUTATHIONE; PROTEIN; OBESITY; CELLS; STATE
AB Oxidized extracellular redox states have been associated with many diseases related to obesity, including heart disease and diabetes, but relatively little is known about the relationship between extracellular redox states and obesity. In 3T3-L1 preadipocytes, oxidizing extracellular redox potentials (Eh) increased intracellular and mitochondrial reactive oxygen species (ROS) production. 3T3-L1 adipocytes showed a greater response to extracellular E-h, producing more intracellular ROS, than preadipocytes. 3T3-L1 adipocytes also produced more extracellular ROS and re-regulated the extracellular E-h to a more oxidizing state than preadipocytes. During 3T3-L1 differentiation, cellular glutathione and mitochondrial thioredoxin-2 become oxidized, suggesting that adipogenesis may be enhanced under conditions promoting intracellular and mitochondrial compartment oxidation. Under various extracellular E-h, 3T3-L1 adipogenesis, as determined by lipid accumulation and the expression of early genetic markers of adipogenesis, was sensitive to the extracellular redox environment, where it was enhanced under oxidizing conditions and lower under reducing conditions. Using a diet-induced obesity mouse model, plasma was collected before and after the 8 week diet regimens. Plasma GSH E-h was unchanged as a consequence of weight gain but plasma cystiene (Cys) Eh was significantly oxidized in overweight animals. Data presented here show that adipocytes/excessive adipose preferentially alter extracellular E-h to a more oxidized state in vivo and in vitro and may promote further adipogenesis. (C) 2010 International Society of Differentiation. Published by Elsevier Ltd. All rights reserved.
C1 [Imhoff, Barry R.; Hansen, Jason M.] Emory Univ, Emory Dept Pediat, Div Pulm Allergy Immunol Cyst Fibrosis & Sleep, Atlanta, GA 30322 USA.
C3 Emory University
RP Hansen, JM (corresponding author), Emory Univ, Emory Dept Pediat, Div Pulm Allergy Immunol Cyst Fibrosis & Sleep, 2015 Uppergate Dr,Room 350, Atlanta, GA 30322 USA.
EM jhansen@emory.edu
FU Emory Egleston Children's Research Committee; Children's Healthcare of
   Atlanta
FX This works was funded through the Emory Egleston Children's Research
   Committee Pilot Program and Children's Healthcare of Atlanta.
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NR 33
TC 45
Z9 52
U1 0
U2 6
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0301-4681
EI 1432-0436
J9 DIFFERENTIATION
JI Differentiation
PD JUL
PY 2010
VL 80
IS 1
BP 31
EP 39
DI 10.1016/j.diff.2010.04.005
PG 9
WC Cell Biology; Developmental Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Developmental Biology
GA 672QO
UT WOS:000283602200004
PM 20471742
DA 2025-06-11
ER

PT J
AU Kojima, T
   Norose, T
   Tsuchiya, K
   Sakamoto, K
AF Kojima, Takayuki
   Norose, Takanari
   Tsuchiya, Keita
   Sakamoto, Kazuichi
TI Mouse 3T3-L1 cells acquire resistance against oxidative stress as the
   adipocytes differentiate via the transcription factor FoxO
SO APOPTOSIS
LA English
DT Article
DE ROS; Apoptosis; 3T3-L1; FoxO; Antioxidative enzymes
ID ADIPOSE-TISSUE; INDUCED APOPTOSIS; GENE-EXPRESSION; FATTY-ACIDS;
   ACTIVATION; BIM; INDUCTION; BAX; RECEPTORS; PROTECTS
AB Repression of excessive increase and enlargement of adipocytes that is closely associated with obesity is effective in the prevention and treatment of metabolic syndrome. Generally, apoptosis is induced in cells via a wide variety of intracellular or extracellular substances, and recently, it has been suggested that the FoxO subfamily is involved in the induction of apoptosis. We aimed to elucidate the mechanism of FoxO-mediated apoptosis-induction in the adipocytes under the reactive oxygen species (ROS) stimulus. The treatment of differentiated and undifferentiated 3T3-L1 cells with glucose oxidase (GOD), an enzyme that generates H2O2, induced apoptosis and led to the accumulation of 8-OHdG. Apoptosis analysis revealed that GOD treatment induced apoptosis in differentiated 3T3-L1 cells less efficiently than in undifferentiated preadipocytes. GOD remarkably increased the levels of Bad, Bax, and Bim-the genes that are actively involved in cell apoptosis. GOD treatment also increased the expression of FoxO3a mRNA and protein. The introduction of FoxO3a-siRNA into 3T3-L1 cells suppressed the oxidative stress-induced expression of Bim mRNA, as well as the GOD-induced apoptosis. Furthermore, the expression of MnSOD, Cu/ZnSOD, and catalase, as well as of FoxO, increased significantly along with the progression of adipocyte differentiation. These results indicated that ROS-induced apoptosis in undifferentiated 3T3-L1 cells via the expression of FoxO3a, whereas FoxO expression suppressed the ROS-induced apoptosis in differentiated 3T3-L1 cells via the expression of ROS-scavenging enzymes.
C1 [Kojima, Takayuki; Norose, Takanari; Tsuchiya, Keita; Sakamoto, Kazuichi] Univ Tsukuba, Grad Sch Life & Environm Sci, Tsukuba, Ibaraki 3058572, Japan.
C3 University of Tsukuba
RP Sakamoto, K (corresponding author), Univ Tsukuba, Grad Sch Life & Environm Sci, 1-1-1 Tennoudai, Tsukuba, Ibaraki 3058572, Japan.
EM sakamoto@biol.tsukuba.ac.jp
FU Ministry of Education, Science, Sports, and Culture of Japan
FX This work was supported in part by Grants-in-Aid for Scientific Research
   from the Ministry of Education, Science, Sports, and Culture of Japan.
   We wish to thank Dr. Keisuke Munekata (University of Tsukuba) for
   providing adenovirus (Ad-FoxO1Si, Ad-FoxO3aSi, Ad-NCSi) for RNAi and to
   his helpful discussion.
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NR 50
TC 24
Z9 29
U1 0
U2 7
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1360-8185
EI 1573-675X
J9 APOPTOSIS
JI Apoptosis
PD JAN
PY 2010
VL 15
IS 1
BP 83
EP 93
DI 10.1007/s10495-009-0415-x
PG 11
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA 539DT
UT WOS:000273234400008
PM 19842039
DA 2025-06-11
ER

PT J
AU Khamar, T
   Jahani, N
   Jafari-Nozad, AM
   Farkhondeh, T
   Samarghandian, S
AF Khamar, Tayybeh
   Jahani, Najmeh
   Jafari-Nozad, Amir Masoud
   Farkhondeh, Tahereh
   Samarghandian, Saeed
TI Beneficial Effects of Curcumin in Polycystic Ovary Syndrome: A Review of
   Recent Literature and Underlying Mechanisms
SO CURRENT MEDICINAL CHEMISTRY
LA English
DT Article; Early Access
DE Antioxidant; curcumin; infertility; phytochemical; polycystic ovary
   syndrome
ID OXIDATIVE STRESS; INSULIN-RESISTANCE; LUTEINIZING-HORMONE;
   GENE-EXPRESSION; SYNDROME PCOS; WOMEN; ANTIOXIDANT; MODEL;
   SUPPLEMENTATION; POLYMORPHISMS
AB Polycystic Ovary Syndrome (PCOS) is a common endocrinological disorder that affects women of reproductive age and can lead to infertility. The prevalence of PCOS ranges from 5-21% depending on the diagnostic criteria and study population. Clinical manifestations include irregular or absent menstrual periods, obesity, and signs of hyperandrogenism. PCOS can also lead to long-term consequences such as metabolic syndrome, increased risk of cardiovascular diseases, endometrial cancer, diabetes mellitus, and hypertension. Metformin and oral contraceptive pills are the most commonly used drugs for PCOS management, but their efficiency is limited and they have some considerable side effects. Researchers are looking into alternative therapeutic options such as phytochemicals. Curcumin (CUR) is a polyphenolic compound found in the rhizome of Curcuma longa and has shown promising effects for females with PCOS. CUR exerts its anti-PCOS effects through different mechanisms such as reducing oxidative stress and inflammation, balancing hormone levels, and controlling the blood sugar and lipid profile. It can also reduce insulin resistance, regulate menstruation, and improve ovarian morphology and function. Despite its beneficial effects, CUR faces several challenges and limitations in clinical use, such as low bioavailability, instability, and rapid elimination. Therefore, researchers are investigating the potential of CUR nanoformulations and new drug delivery systems to overcome these barriers. With growing evidence regarding the potential role of CUR in PCOS treatment, we decided to provide an updated summary of the recent literature from clinical and preclinical studies on this topic.
C1 [Khamar, Tayybeh] Zahedan Univ Med Sci, Student Res Comm, Fac Med, Zahedan, Iran.
   [Khamar, Tayybeh] Zahedan Univ Med Sci, Dept Obstet & Gynecol, Sch Med, Zahedan, Iran.
   [Jahani, Najmeh] Birjand Univ Med Sci, Valiasr Hosp, Sch Med, Dept Gynecol, Birjand, Iran.
   [Jafari-Nozad, Amir Masoud] Birjand Univ Med Sci, Student Res Comm, Birjand, Iran.
   [Farkhondeh, Tahereh] Birjand Univ Med Sci, Sch Pharm, Dept Toxicol & Pharmacol, Birjand, Iran.
   [Samarghandian, Saeed] Neyshabur Univ Med Sci, Fac Med, Dept Pathol, Neyshabur, Iran.
C3 Zahedan University of Medical Sciences; Zahedan University of Medical
   Sciences; Birjand University of Medical Sciences; Birjand University of
   Medical Sciences; Birjand University of Medical Sciences
RP Farkhondeh, T (corresponding author), Birjand Univ Med Sci, Sch Pharm, Dept Toxicol & Pharmacol, Birjand, Iran.; Samarghandian, S (corresponding author), Neyshabur Univ Med Sci, Fac Med, Dept Pathol, Neyshabur, Iran.
EM farkhondeh2324@gmail.com; samarghandians1@nums.ac.ir
RI Farkhondeh, Tahereh/Y-2083-2018
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NR 132
TC 0
Z9 0
U1 1
U2 1
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 0929-8673
EI 1875-533X
J9 CURR MED CHEM
JI Curr. Med. Chem.
PD 2024 OCT 17
PY 2024
DI 10.2174/0109298673320502241002075427
EA OCT 2024
PG 17
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Pharmacology &
   Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
GA J5F2D
UT WOS:001337311500001
PM 39421997
DA 2025-06-11
ER

PT J
AU Abu Bakar, NAF
   Ahmad, A
   Musa, WZW
   Shahril, MR
   Wan-Arfah, N
   Majid, HA
   Piernas, C
   Ramli, AW
   Naing, NN
AF Abu Bakar, Nur Ain Fatinah
   Ahmad, Aryati
   Musa, Wan Zulaika Wan
   Shahril, Mohd Razif
   Wan-Arfah, Nadiah
   Majid, Hazreen Abdul
   Piernas, Carmen
   Ramli, Ahmad Wazi
   Naing, Nyi Nyi
TI Association between a dietary pattern high in saturated fatty acids,
   dietary energy density, and sodium with coronary heart disease
SO SCIENTIFIC REPORTS
LA English
DT Article
ID PERCEIVED STRESS SCALE; PHYSICAL-ACTIVITY; MALAY VERSION; RISK;
   RELIABILITY; INCREASES; STROKE; HEALTH; ADULTS
AB This study aimed to determine the association between dietary pattern (DP) and coronary heart disease (CHD) among high-risk adults as determined by metabolic syndrome (MetS) criteria in Malaysia. This cross-sectional study involved 365 participants with (CHD = 178; non-CHD = 187) who were recruited from selected health clinics. Dietary intake was measured using a 189-item semi-quantitative foods frequency questionnaire (FFQ) whilst anthropometry and clinical data were measured by trained researcher and biochemical data were obtained from medical records. The reduced rank regression (RRR) method was used to derive DPs scores and binary logistic regression was used to assess the associations between identified DPs and CHD. The main DP found in this study was characterised by "high saturated fatty acid (SFA), high dietary energy density (DED), high sodium". This DP, which is attributed to high consumption of coconut-based dishes, fast foods and snacks, rice dishes, fat spread, seasoning sauces, salted and processed foods, and low intake of fruits, green leafy vegetables, white rice and other vegetables were associated with CHD (OR:1.32, 95% CI:1.03, 1.69) p value = 0.026 when, adjusted for age, sex, race, education level, household income, family history of CHD, marital status, smoking status, physical activity, stress level and BMI. This study suggests that individuals with a DP of high SFA, high DED, and high sodium have a significantly increased likelihood of having CHD compared to those who do not practice this DP.
C1 [Abu Bakar, Nur Ain Fatinah; Ahmad, Aryati; Musa, Wan Zulaika Wan; Wan-Arfah, Nadiah] Univ Sultan Zainal Abidin UniSZA, Fac Hlth Sci, Terengganu, Malaysia.
   [Ahmad, Aryati; Piernas, Carmen] Univ Oxford, Nuffield Dept Primary Care Hlth Sci, Oxford, England.
   [Shahril, Mohd Razif] Univ Kebangsaan Malaysia, Fac Hlth Sci, Ctr Hlth Ageing & Wellness HCARE, Kuala Lumpur, Malaysia.
   [Majid, Hazreen Abdul] Univ Malaya, Fac Med, Dept Social & Prevent Med, Kuala Lumpur, Malaysia.
   [Ramli, Ahmad Wazi] Hosp Sultanah Nur Zahirah HSNZ, Med Dept, Terengganu, Malaysia.
   [Naing, Nyi Nyi] Univ Sultan Zainal Abidin UniSZA, Fac Med, Terengganu, Malaysia.
C3 Universiti Sultan Zainal Abidin; University of Oxford; Universiti
   Kebangsaan Malaysia; Universiti Malaya; Universiti Sultan Zainal Abidin
RP Ahmad, A (corresponding author), Univ Sultan Zainal Abidin UniSZA, Fac Hlth Sci, Terengganu, Malaysia.; Ahmad, A (corresponding author), Univ Oxford, Nuffield Dept Primary Care Hlth Sci, Oxford, England.
EM aryatiahmad@unisza.edu.my
RI Piernas, Carmen/AAT-8276-2020; ABU BAKAR, NUR AIN/HZL-0037-2023;
   Wan-Arfah, Nadiah/AAZ-1317-2021; Shahril, Mohd Razif/K-7320-2015; Naing,
   Nyi/M-3455-2015; Abdul Majid, Hazreen/B-8619-2010
OI , Wan-Arfah Nadiah/0000-0002-4265-442X; Abdul Majid,
   Hazreen/0000-0002-2718-8424
FU Special Research Grant Scheme (SRGS) [UniSZA: 2017/SRGS/13]
FX This research project was funded by Special Research Grant Scheme (SRGS)
   (UniSZA: 2017/SRGS/13). Special acknowledgement to all participants,
   staff of the Ministry of Health (MOH), and members of study team for
   their contribution to this project.
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NR 65
TC 12
Z9 12
U1 0
U2 3
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD JUL 29
PY 2022
VL 12
IS 1
AR 13049
DI 10.1038/s41598-022-17388-5
PG 11
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 3J3ZD
UT WOS:000833335700078
PM 35906378
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Albrahim, T
   Alonazi, M
AF Albrahim, Tarfa
   Alonazi, Mona
TI Effect of Blueberry Extract on Liver in Aged Rats
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Article
ID ANTIOXIDANT CAPACITY; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   PHENOLIC-COMPOUNDS; OXIDATIVE STRESS; INFLAMMATION; BRAIN; POLYPHENOLS
AB Aging and age-related disorders are prominent issues. Aging is associated with a gradual impairment of physiology at the genetic, cellular, tissue, and whole organism level that directly influences the development of chronic diseases and organ failure. Blueberries, on the other hand, are well known for their high content of bioactive compounds and have demonstrated positive impacts on metabolic factors that influence health and general well-being. This study is aimed at evaluating the ameliorating the effects of blueberry on the liver of aged rats by monitoring changes in metabolic disturbances, oxidative stress, and inflammatory disruption. The aged group of rats was orally administered with blueberry extract (200 mg/kg) for a period of 4 weeks. The results revealed that aging was associated with an increase in body weight, liver weight, and metabolic parameters like serum insulin, triglycerides, total cholesterol, and liver function markers accompanied with a decrease in vitamin D levels. Furthermore, the results showed a significant diminish in the activities of antioxidant enzymes, glutathione content with an elevation in lipid peroxidation, inflammatory mediators (tumor necrosis factor alpha, interleukin 6, and nuclear factor kappa-light-chain-enhancer of activated B cells) as well as fibrotic markers (TGF-beta 1) in the liver of aged rats. Compared to the young rats (control group), blueberry effectively reversed age-mediated disruption of the aforementioned parameters. Hence, blueberries can be used as a potential therapeutic strategy for the management of age-related liver dysfunction and disease.
C1 [Albrahim, Tarfa] Princess Nourah Bint Abdulrahman Univ, Coll Hlth & Rehabil Sci, Dept Hlth Sci, Clin Nutr, POB 84428, Riyadh 11671, Saudi Arabia.
   [Alonazi, Mona] King Saud Univ, Sci Coll, Biochem Dept, POB 22452, Riyadh 11495, Saudi Arabia.
C3 Princess Nourah bint Abdulrahman University; King Saud University
RP Albrahim, T (corresponding author), Princess Nourah Bint Abdulrahman Univ, Coll Hlth & Rehabil Sci, Dept Hlth Sci, Clin Nutr, POB 84428, Riyadh 11671, Saudi Arabia.
EM tarfa.ibrahim21@gmail.com; moalonazi@ksu.edu.sa
RI A, Mona/AAF-6911-2019
OI Albrahim, Tarfa/0000-0003-4360-8115
FU Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia
   [PNURS2022R69]
FX AcknowledgmentsPrincess Nourah Bint Abdulrahman University Research
   Supporting Project number (PNURS2022R69), Princess Nourah Bint
   Abdulrahman University, Riyadh, Saudi Arabia, supported this study.
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NR 51
TC 6
Z9 6
U1 2
U2 21
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PD JUL 18
PY 2022
VL 2022
AR 3490776
DI 10.1155/2022/3490776
PG 11
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA 3L9MA
UT WOS:000835083200003
PM 35898615
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Champaneri, S
   Xu, XQ
   Carnethon, MR
   Bertoni, AG
   Seeman, T
   DeSantis, AS
   Roux, AD
   Shrager, S
   Golden, SH
AF Champaneri, Shivam
   Xu, Xiaoqiang
   Carnethon, Mercedes R.
   Bertoni, Alain G.
   Seeman, Teresa
   DeSantis, Amy S.
   Roux, Ana Diez
   Shrager, Sandi
   Golden, Sherita Hill
TI Diurnal Salivary Cortisol Is Associated with Body Mass Index and Waist
   Circumference: The Multiethnic Study of Atherosclerosis
SO OBESITY
LA English
DT Article
ID PITUITARY-ADRENAL AXIS; METABOLIC SYNDROME; ABDOMINAL OBESITY;
   INSULIN-RESISTANCE; VISCERAL FAT; STRESS; MEN; SECRETION; DYSREGULATION;
   ADIPOSITY
AB Objective: Neuroendocrine abnormalities, such as activation of the hypothalamic-pituitary-adrenal (HPA) axis, are associated with obesity; however, few large-scale population-based studies have examined HPA axis and markers of obesity. We examined the cross-sectional association of the cortisol awakening response (CAR) and diurnal salivary cortisol curve with obesity.
   Design and Methods: The Multiethnic Study of Atherosclerosis Stress Study includes 1,002 White, Hispanic, and Black men and women (mean age 65 +/- 9.8 years) who collected up to 18 salivary cortisol samples over 3 days. Cortisol profiles were modeled using regression spline models that incorporated random parameters for subject-specific effects. Cortisol curve measures included awakening cortisol, CAR (awakening to 30-min postawakening), early decline (30 min to 2-h postawakening), late decline (2-h postawakening to bedtime), and the corresponding areas under the curve (AUC). Body mass index (BMI) and waist circumference (WC) were used to estimate adiposity.
   Results: For the entire cohort, both BMI and WC were negatively correlated with awakening cortisol (P < 0.05), AUC during awakening rise, and early decline and positively correlated to the early decline slope (P < 0.05) after adjustments for age, race/ethnicity, gender, diabetes status, socioeconomic status, beta-blockers, steroids, hormone replacement therapy, and smoking status. No heterogeneities of effects were observed by gender, age, and race/ethnicity.
   Conclusions: Higher BMI and WC are associated with neuroendocrine dysregulation, which is present in a large population sample, and only partially explained by other covariates.
C1 [Champaneri, Shivam; Xu, Xiaoqiang; Golden, Sherita Hill] Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21205 USA.
   [Carnethon, Mercedes R.] Northwestern Univ, Feinberg Sch Med, Dept Prevent Med, Chicago, IL 60611 USA.
   [Bertoni, Alain G.] Wake Forest Univ Hlth Sci, Div Publ Hlth Sci, Winston Salem, NC USA.
   [Seeman, Teresa] Univ Calif Los Angeles, David Geffen Sch Med, Div Geriatr, Los Angeles, CA 90095 USA.
   [DeSantis, Amy S.; Roux, Ana Diez] Univ Michigan, Dept Epidemiol, Ann Arbor, MI 48109 USA.
   [Shrager, Sandi] Univ Washington, Dept Biostat, Seattle, WA 98195 USA.
   [Golden, Sherita Hill] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA.
C3 Johns Hopkins University; Northwestern University; Feinberg School of
   Medicine; Wake Forest University; Wake Forest University School of
   Medicine; University of California System; University of California Los
   Angeles; University of California Los Angeles Medical Center; David
   Geffen School of Medicine at UCLA; University of Michigan System;
   University of Michigan; University of Washington; University of
   Washington Seattle; Johns Hopkins University; Johns Hopkins Bloomberg
   School of Public Health
RP Golden, SH (corresponding author), Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21205 USA.
EM sahill@jhmi.edu
RI XU, Xiaoqiang/AAA-5897-2022
OI Bertoni, Alain/0000-0002-7503-6273; Carnethon,
   Mercedes/0000-0001-7035-0848
FU NIH; NHLBI
FX S.C., X.X., M.R.C., A.G.B., T.S., A.S.D., and S.S. have nothing to
   declare. A.D.R. is funded by a research grant from NIH. S.H.G. is funded
   by NIH and NHLBI contracts, which support MESA and MESA Stress Study.
   Full financial disclosures and author notes may be found in the online
   version of this article.
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NR 40
TC 119
Z9 135
U1 0
U2 16
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1930-7381
EI 1930-739X
J9 OBESITY
JI Obesity
PD JAN
PY 2013
VL 21
IS 1
BP E56
EP E63
DI 10.1002/oby.20047
PG 8
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 187AE
UT WOS:000322086900008
PM 23404865
OA Green Accepted, Green Published
DA 2025-06-11
ER

PT J
AU Kendig, EL
   Schneider, SN
   Clegg, DJ
   Genter, MB
   Shertzer, HG
AF Kendig, Eric L.
   Schneider, Scott N.
   Clegg, Deborah J.
   Genter, Mary Beth
   Shertzer, Howard G.
TI Over-the-counter analgesics normalize blood glucose and body composition
   in mice fed a high fat diet
SO BIOCHEMICAL PHARMACOLOGY
LA English
DT Article
DE analgesic drugs; diabetes; high fat diet; mice; NADPH oxidase; oxidative
   stress
ID NF-KAPPA-B; REACTIVE OXYGEN PRODUCTION; OXIDATIVE STRESS;
   CARDIOVASCULAR-DISEASE; DIABETIC-NEPHROPATHY; HYPERGLYCEMIC DAMAGE;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; ASPIRIN; OBESITY
AB Type 2 diabetes (noninsulin-dependent diabetes mellitus) develops from a pre-diabetic condition that is characterized by insulin resistance and glucose intolerance, and is exacerbated by obesity. In this study, we compared the ability of over-the-counter analgesic drugs (OTCAD) [acetaminophen (APAP); ibuprofen (IBU); naproxen (NAP); aspirin (ASA)], to protect against the development of a pre-diabetic state in mice fed a high fat diet. After 10 weeks on the high fat diet, mice had normal fasting blood glucose (FBG) levels, but exhibited impaired glucose tolerance. Treatment with 20 mg OTCADs/kg body weight improved glucose tolerance, with the order of efficacy, APAP = ASA > IBU, while NAP proved ineffective. Mice fed the high fat diet also exhibited increases in weight gain associated with an increase in body fat. OTCADs prevented in part this increase in body fat, in the order of efficacy, APAP = IBU > NAP = ASA. In isolated liver mitochondria, OTCADs inhibited succinate-dependent H2O2 production, while in white adipose tissue, APAP inhibited NADPH-oxidase mediated H2O2 production and lipid peroxidation. Thus, OTCADs diminish pro-oxidant processes that might otherwise exacerbate inflammation and a pre-diabetic state. We conclude that OTCADs, especially APAP and IBU, may be valuable tools to delay or prevent the development of type 2 diabetes from a pre-diabetic condition. (C) 2008 Elsevier Inc. All rights reserved.
C1 [Kendig, Eric L.; Schneider, Scott N.; Genter, Mary Beth; Shertzer, Howard G.] Univ Cincinnati, Coll Med, Dept Environm Hlth, Cincinnati, OH 45267 USA.
   [Kendig, Eric L.; Schneider, Scott N.; Genter, Mary Beth; Shertzer, Howard G.] Univ Cincinnati, Coll Med, Ctr Environm Genet, Cincinnati, OH 45267 USA.
   [Clegg, Deborah J.] Univ Texas SW Med Ctr Dallas, Touchstone Diabet Ctr, Dept Internal Med, Dallas, TX 75390 USA.
C3 University System of Ohio; University of Cincinnati; University System
   of Ohio; University of Cincinnati; University of Texas System;
   University of Texas Southwestern Medical Center Dallas
RP Shertzer, HG (corresponding author), Univ Cincinnati, Coll Med, Dept Environm Hlth, 3223 Eden Ave, Cincinnati, OH 45267 USA.
EM shertzhg@ucmail.uc.edu
FU NIEHS NIH HHS [P30 ES06096] Funding Source: Medline
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NR 58
TC 16
Z9 20
U1 0
U2 7
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0006-2952
EI 1873-2968
J9 BIOCHEM PHARMACOL
JI Biochem. Pharmacol.
PD JUL 15
PY 2008
VL 76
IS 2
BP 216
EP 224
DI 10.1016/j.bcp.2008.05.001
PG 9
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 324YP
UT WOS:000257555600008
PM 18554574
DA 2025-06-11
ER

PT J
AU Schreuder, TCMA
   Verwer, BJ
   van Nieuwkerk, CMJ
   Mulder, CJJ
AF Schreuder, Tim C. M. A.
   Verwer, Bart J.
   van Nieuwkerk, Carin M. J.
   Mulder, Chris J. J.
TI Nonalcoholic fatty liver disease: An overview of current insights in
   pathogenesis, diagnosis and treatment
SO WORLD JOURNAL OF GASTROENTEROLOGY
LA English
DT Review
DE non-alcoholic fatty liver disease; non-alcoholic steatohepatitis;
   insulin resistance; liver; obesity; steatosis
ID NECROSIS-FACTOR-ALPHA; ENDOPLASMIC-RETICULUM STRESS; HEPATIC
   CYTOCHROME-P450 2E1; LEPTIN-REPLACEMENT THERAPY; PLACEBO-CONTROLLED
   TRIAL; INSULIN-RESISTANCE; METABOLIC SYNDROME; VITAMIN-E;
   ADIPOSE-TISSUE; ALANINE AMINOTRANSFERASE
AB Estimates of people suffering from overweight (one billion) and obesity (300 million) are increasing. The accumulation of triglycerides in the liver, in the absence of excess alcohol intake, has been described in the early sixties, It was not until 1980, however, that Ludwig et al named this condition nonalcoholic steatohepatitis (NASH). Subsequently, nonalcoholic fatty liver disease (NAFLD) has been used as a general name for conditions ranging from simple steatosis through steatohepatitis to end-stage liver disease (cirrhosis). Many studies have demonstrated the significant correlation with obesity and insulin resistance. Other studies have revealed a significant correlation between hepatic steatosis, cardiovascular disease and increased intima-media thickness. WHO estimated that at least two million patients will develop cirrhosis due to hepatic steatosis in the years to come. Longitudinal cohort studies have demonstrated that those patients with cirrhosis have a similar risk to develop hepatocellular carcinoma as those with other causes of cirrhosis. Taken all together, NAFLD has become the third most important indication for liver transplantation. Therefore, training programmes in internal medicine, gastroenterology and hepatology should stress the importance of diagnosing this entity and treat properly those at risk for developing complications of portal hypertension and concomittant cardiovascular disease. This review will focus on the clinical characteristics, pathophysiology, imaging techniques and the readily available therapeutic options. (C) 2008 WJG. All rights reserved.
C1 [Schreuder, Tim C. M. A.; Verwer, Bart J.; van Nieuwkerk, Carin M. J.; Mulder, Chris J. J.] Vrije Univ Amsterdam Med Ctr, Dept Gastroenterol & Hepatol, NL-1007 MB Amsterdam, Netherlands.
C3 Vrije Universiteit Amsterdam; VU UNIVERSITY MEDICAL CENTER
RP Schreuder, TCMA (corresponding author), Vrije Univ Amsterdam Med Ctr, Dept Gastroenterol & Hepatol, POB 7057, NL-1007 MB Amsterdam, Netherlands.
EM t.schreuder@vumc.nl
RI Kluin-Nelemans, Johanna/F-8658-2018
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NR 164
TC 158
Z9 175
U1 2
U2 28
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 8226 REGENCY DR, PLEASANTON, CA 94588 USA
SN 1007-9327
EI 2219-2840
J9 WORLD J GASTROENTERO
JI World J. Gastroenterol.
PD APR 28
PY 2008
VL 14
IS 16
BP 2474
EP 2486
DI 10.3748/wjg.14.2474
PG 13
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 295TN
UT WOS:000255496900002
PM 18442193
OA hybrid, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Itoh, H
   Tanaka, M
AF Itoh, Hiroshi
   Tanaka, Masami
TI "Greedy Organs Hypothesis" for sugar and salt in the pathophysiology of
   non-communicable diseases in relation to sodium-glucose co-transporters
   in the intestines and the kidney
SO METABOLISM OPEN
LA English
DT Article
DE Sodium-glucose cotransporter; Diabetes mellitus; Chronic kidney disease;
   Non-communicable diseases; Metabolic syndrome; Obesity
ID RECEPTOR TRANSCRIPTIONAL ACTIVITY; CONVERTING ENZYME-INHIBITOR;
   MINERALOCORTICOID RECEPTOR; MESSENGER-RNA; SENSITIVE HYPERTENSION;
   DIABETIC-NEPHROPATHY; OXIDATIVE STRESS; RAC1 GTPASE; EXPRESSION; PROTEIN
AB Deposition of visceral fat and insulin resistance play central role in the development of non -communicable diseases (NCDs) including obesity, hypertension and type 2 diabetes. However, we shed more light upon the intestines and the kidney as a strong driver of NCDs. Based upon unexpected outcomes of clinical trials using sodium -glucose cotransporter (SGLT) 2 inhibitors to demonstrate their actions for not only body weight reduction and blood glucose fall but also remarkable cardiorenal protection, we speculate that hyperfunction of the intestines and the kidney is one of critical contributing factors for initiation of NCDs. By detecting high amount of glucose and sodium chloride around them by sweet/salt taste sensors, the intestines and the kidney are designed to (re)absorb these nutrients by up -regulating SGLT1 or SGLT2. We designate these hyperfunctioning organs for nutrient uptake as "greedy organs". The greedy organs can induce NCDs ("greedy organ hypothesis"). SGLTs are regulated by glucose and sodium chloride, and SGLTs or other genes can be "greedy genes." Regulating factors for greedy organs are renin-angiotensin system, renal sympathetic nervous activity, gut inflammation/microbiota or oxidative stress. Mitigation of organ greediness by SGLT2 inhibitors, ketone bodies, bariatric surgery, and regular lifestyle to keep rhythmicity of biological clock are promising.
C1 [Itoh, Hiroshi] Keio Univ, Sch Med, Dept Endocrinol Metab & Nephrol, 35 Shinanomachi,Shinju ku, Tokyo 1608582, Japan.
   [Tanaka, Masami] Tokyo Womens Med Univ, Adachi Med Ctr, Dept Med, Sch Med, Kohoku 4-33-1,Adachi ku, Tokyo 1238558, Japan.
C3 Keio University; Tokyo Women's Medical University
RP Itoh, H (corresponding author), Keio Univ, Sch Med, Dept Endocrinol Metab & Nephrol, 35 Shinanomachi,Shinju ku, Tokyo 1608582, Japan.
EM hiito@keio.jp
FU Advanced Research and Development Programs for Medical Innovation
   (AMED-CREST)
FX HI was supported by Grants-in-Aid for Scientific Research (A) ,
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NR 94
TC 4
Z9 5
U1 1
U2 4
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
EI 2589-9368
J9 METAB OPEN
JI Metab. Open
PD MAR
PY 2022
VL 13
AR 100169
DI 10.1016/j.metop.2022.100169
PG 9
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA JF8G1
UT WOS:001171837900008
PM 35198947
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Korolczuk, A
   Dudka, J
AF Korolczuk, Agnieszka
   Dudka, Jaroslaw
TI Increased Risk of Cardiovascular Complications in Chronic Kidney
   Disease: A Possible Role of Leptin
SO CURRENT PHARMACEUTICAL DESIGN
LA English
DT Article
DE Leptin; cardiovascular disease; chronic kidney disease; obesity
ID STAGE RENAL-DISEASE; OBESITY-RELATED GLOMERULOPATHY; EVALUATION-PROGRAM
   KEEP; SERUM LEPTIN; PLASMA LEPTIN; OXIDATIVE STRESS;
   HEMODIALYSIS-PATIENTS; BLOOD-PRESSURE; PERITONEAL-DIALYSIS; BODY-FAT
AB Leptin is a small peptide hormone (16 kDa), a product of the obesity gene (Ob), and is mainly synthesized and secreted by adipocytes. It is removed from the blood by the kidneys. The kidney is not only a site of leptin clearance, but also a target organ for its action in different pathophysiological states. Several studies have documented a strong relationship between chronic kidney disease (CKD) and accelerated cardiovascular disease (CVD) defined as a cardiorenal syndrome. Patients with stage 3 and 4 CKD develop cardiovascular complications and are at increased risk of death from CVD. Renal dysfunction promotes several mechanisms responsible for exacerbation of cardiovascular disease. These include activation of the renin-angiotensin system, oxidative stress, elevated asymmetric dimethylarginine (ADMA), low-grade inflammation with increased circulating cytokines, and dyslipidemia. Recently, it has been observed that plasma leptin level is elevated in patients with cardiorenal syndrome. In obesity, hyperleptinemia combined with selective leptin resistance appear to have a critical role in the development and progression of kidney disease, CVD and metabolic syndrome. This has clinical implications for the treatment of obesity-related hypertension and kidney disease. In this paper the role of leptin in chronic kidney disease and accelerated cardiovascular disease is out lined. The link between hyperleptinemia and development and progression of morphologic changes that effect kidney in obese patients is also discussed.
C1 [Korolczuk, Agnieszka] Med Univ Lublin, Dept Clin Pathomorphol, Lublin, Poland.
   [Dudka, Jaroslaw] Med Univ Lublin, Med Biol Unit, Lublin, Poland.
C3 Medical University of Lublin; Medical University of Lublin
RP Korolczuk, A (corresponding author), Swietochowskiego 23, PL-20467 Lublin, Poland.
EM agnieszka.korolczuk@wp.pl
OI Korolczuk, Agnieszka/0000-0003-1016-2735
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NR 132
TC 8
Z9 11
U1 0
U2 10
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1381-6128
EI 1873-4286
J9 CURR PHARM DESIGN
JI Curr. Pharm. Design
PD FEB
PY 2014
VL 20
IS 4
BP 666
EP 674
DI 10.2174/13816128113199990013
PG 9
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA AE9DV
UT WOS:000334305800023
PM 23688007
DA 2025-06-11
ER

PT J
AU van Dijk, SJ
   Feskens, EJM
   Bos, MB
   de Groot, LCPGM
   de Vries, JHM
   Müller, M
   Afman, LA
AF van Dijk, Susan J.
   Feskens, Edith J. M.
   Bos, Marieke B.
   de Groot, Lisette C. P. G. M.
   de Vries, Jeanne H. M.
   Muller, Michael
   Afman, Lydia A.
TI Consumption of a High Monounsaturated Fat Diet Reduces Oxidative
   Phosphorylation Gene Expression in Peripheral Blood Mononuclear Cells of
   Abdominally Overweight Men and Women
SO JOURNAL OF NUTRITION
LA English
DT Article
ID VIRGIN OLIVE OIL; MEDITERRANEAN DIET; METABOLIC SYNDROME;
   SKELETAL-MUSCLE; GROWTH-FACTOR; HEALTH; NUTRIGENOMICS; STRESS; HUMANS;
   COMPLICATIONS
AB The Mediterranean (MED) diet is often considered health-promoting due to its high content of MUFA and polyphenols. These bioactive compounds can affect gene expression and accordingly may regulate pathways and proteins related to cardiovascular disease prevention. This study aimed to identify the effects of a MED-type diet, and the replacement of SEA with MUFA in a Western-type diet, on peripheral blood mononuclear cell (PBMC) gene expression and plasma proteins. Abdominally overweight men and women (waist: women >= 80 cm, men >= 94 cm) were allocated to an 8-wk, completely controlled SFA diet (19% daily energy as SFA), a MUFA diet (20% daily energy MUFA), or a MED diet (21% daily energy MUFA). Concentrations of 124 plasma proteins and PBMC whole-genome transcriptional profiles were assessed. Consumption of the MUFA and MED diets, compared with the SFA diet, decreased the expression of oxidative phosphorylation (OXPHOS) genes, plasma connective tissue growth factor, and apoB concentrations. Compared with the MED and SFA diets, the MUFA diet changed the expression of genes involved in B-cell receptor signaling and endocytosis signaling. Participants who consumed the MED diet had lower concentrations of proinflammatory proteins at 8 wk compared with baseline. We hypothesize that replacement of SFA with MUFA may improve health, thereby reducing metabolic stress and OXPHOS activity in PBMC. The MED diet may have additional antiatherogenic effects by lowering proinflammatory plasma proteins. J. Nutr. 142: 1219-1225, 2012.
C1 [van Dijk, Susan J.; Feskens, Edith J. M.; Bos, Marieke B.; de Groot, Lisette C. P. G. M.; de Vries, Jeanne H. M.; Muller, Michael; Afman, Lydia A.] Wageningen Univ, Div Human Nutr, Wageningen, Netherlands.
   [Muller, Michael] Netherlands Nutrigenom Ctr, Wageningen, Netherlands.
C3 Wageningen University & Research
RP Afman, LA (corresponding author), Wageningen Univ, Div Human Nutr, Wageningen, Netherlands.
EM Lydia.afman@wur.nl
RI Muller, Michael/M-5724-2019; Afman, Lydia/A-2463-2011; Feskens,
   Edith/ABI-1446-2020; Muller, Michael/B-5795-2008; /H-8910-2013
OI Muller, Michael/0000-0002-5930-9905; Feskens, Edith/0000-0001-5819-2488;
   /0000-0001-7019-0418; de Groot, Lisette/0000-0003-2778-2789
FU Dutch Diabetes Research Foundation [20060052]; Netherlands Heart
   Foundation [2003B068]; Netherlands Nutrigenomics Consortium
FX Supported by the Dutch Diabetes Research Foundation (20060052), the
   Netherlands Heart Foundation (2003B068), and the Netherlands
   Nutrigenomics Consortium.
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NR 48
TC 52
Z9 57
U1 0
U2 13
PU AMER SOC NUTRITION-ASN
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-3166
J9 J NUTR
JI J. Nutr.
PD JUL
PY 2012
VL 142
IS 7
BP 1219
EP 1225
DI 10.3945/jn.111.155283
PG 7
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 963AP
UT WOS:000305592800006
PM 22623392
OA Bronze
DA 2025-06-11
ER

PT J
AU Saka, SO
   Salisu, YY
   Sahabi, HM
   Sanusi, KO
   Ibrahim, KG
   Abubakar, MB
   Isa, SA
   Liman, MG
   Shehu, S
   Malami, I
   Chan, KW
   Azmi, NH
   Imam, MU
AF Saka, Saheed Olanrewaju
   Salisu, Yusuf Yahaya
   Sahabi, Hauwa'u Muhammad
   Sanusi, Kamaldeen Olalekan
   Ibrahim, Kasimu Ghandi
   Abubakar, Murtala Bello
   Isa, Suleiman Ahmed
   Liman, Muhammad Gidado
   Shehu, Sha'aya'u
   Malami, Ibrahim
   Chan, Kim Wei
   Azmi, Nur Hanisah
   Imam, Mustapha Umar
TI Nutrigenomic Effects of White Rice and Brown Rice on the Pathogenesis of
   Metabolic Disorders in a Fruit Fly Model
SO MOLECULES
LA English
DT Article
DE brown rice; white rice; metabolic syndrome; insulin resistance; dPEPCK;
   dIRS; dACC; oxidative stress; obesity; fruit fly
ID HIGH-FAT-DIET; HEPATIC CHOLESTEROL-METABOLISM; CARDIOVASCULAR-DISEASE
   RISK; INSULIN-RESISTANCE; OXIDATIVE STRESS; PROXIMATE COMPOSITION;
   ANTIOXIDANT ACTIVITY; GLUCOSE-METABOLISM; DOWN-REGULATION;
   GAMMA-ORYZANOL
AB Consumption of white rice (WR) has been shown to predispose individuals to metabolic disorders. However, brown rice (BR), which is relatively richer in bioactive compounds, possesses anti-glycaemic and antioxidant effects. In this study, fifteen cultivars of paddy rice that are predominantly consumed in North West Nigeria were analysed for their nutritional composition, bioactive contents and effects on metabolic outcomes in a fruit fly model. Gene expression analyses were conducted on the whole fly, targeting dPEPCK, dIRS, and dACC. The protein, carbohydrate, and fibre contents and bioactives of all BR cultivars were significantly different (p < 0.05) from the WR cultivars. Moreover, it was demonstrated that the glucose and trehalose levels were significantly higher (p < 0.05), while glycogen was significantly lower (p < 0.05) in the WR groups compared to the BR groups. Similarly, the expression of dACC and dPEPCK was upregulated, while that of dIRS was downregulated in the WR groups compared to the BR groups. Sex differences (p < 0.05) were observed in the WR groups in relation to the nutrigenomic effects. Our findings confirm metabolic perturbations in fruit flies following consumption of WR via distortion of insulin signalling and activation of glycogenolysis and gluconeogenesis. BR prevented these metabolic changes possibly due to its richer nutritional composition.
C1 [Saka, Saheed Olanrewaju; Salisu, Yusuf Yahaya; Sahabi, Hauwa'u Muhammad; Sanusi, Kamaldeen Olalekan; Ibrahim, Kasimu Ghandi; Abubakar, Murtala Bello; Malami, Ibrahim; Imam, Mustapha Umar] Usmanu Danfodiyo Univ, Ctr Adv Med Res & Training, Sokoto PMB 2254, Sokoto, Nigeria.
   [Saka, Saheed Olanrewaju; Sanusi, Kamaldeen Olalekan; Ibrahim, Kasimu Ghandi; Abubakar, Murtala Bello] Usmanu Danfodiyo Univ, Coll Hlth Sci, Fac Basic Med Sci, Dept Physiol, Sokoto PMB 2346, Sokoto, Nigeria.
   [Salisu, Yusuf Yahaya; Sahabi, Hauwa'u Muhammad; Isa, Suleiman Ahmed; Shehu, Sha'aya'u] Usmanu Danfodiyo Univ, Fac Sci, Dept Biochem & Mol Biol, Sokoto PMB 2346, Sokoto, Nigeria.
   [Ibrahim, Kasimu Ghandi] Zarqa Univ, Fac Dent, Dept Basic Med & Dent Sci, Zarqa 13110, Jordan.
   [Liman, Muhammad Gidado] Usmanu Danfodiyo Univ, Fac Sci, Dept Pure & Appl Chem, Sokoto PMB 2346, Sokoto, Nigeria.
   [Malami, Ibrahim] Usmanu Danfodiyo Univ, Fac Pharmaceut Sci, Dept Pharmacognosy & Ethnopharmacy, Sokoto PMB 2346, Sokoto, Nigeria.
   [Chan, Kim Wei] Univ Putra Malaysia, UPM, Inst Biosci, Nat Med & Prod Res Lab, Serdang 43400, Selangor, Malaysia.
   [Azmi, Nur Hanisah] Univ Malaysia Sabah, Fac Food Sci & Nutr, Kota Kinabalu 88400, Sabah, Malaysia.
   [Imam, Mustapha Umar] Usmanu Danfodiyo Univ, Coll Hlth Sci, Fac Basic Med Sci, Dept Med Biochem, Sokoto PMB 2346, Sokoto, Nigeria.
C3 Zarqa University; Universiti Putra Malaysia; Universiti Malaysia Sabah
RP Imam, MU (corresponding author), Usmanu Danfodiyo Univ, Ctr Adv Med Res & Training, Sokoto PMB 2254, Sokoto, Nigeria.; Imam, MU (corresponding author), Usmanu Danfodiyo Univ, Coll Hlth Sci, Fac Basic Med Sci, Dept Med Biochem, Sokoto PMB 2346, Sokoto, Nigeria.
EM mustyimam@gmail.com
RI Malami, Ibrahim/C-4513-2019; AZMI, NUR HANISAH/J-6735-2019; Abubakar,
   Murtala/G-8964-2016; Imam, Mustapha/K-3490-2012; Kane,
   Sonila/GRY-7161-2022; Sanusi, Kamaldeen Olalekan/A-6438-2016; Ghandi,
   Kasimu/L-7904-2017
OI Chan, Kim Wei/0000-0003-3028-0800; Imam, Mustapha
   Umar/0000-0001-9888-4809; Sanusi, Kamaldeen
   Olalekan/0000-0002-9588-7710; , Salisu Yusuf Yahaya/0000-0002-3770-7187;
   Ghandi, Kasimu/0000-0002-2119-580X
FU Institution-based research (IBR) grant of the Tertiary Education Trust
   Fund (TETFUND) of Nigeria [TETF/DR&D/CE/UNIV/SOKOTO/IBR/2016/VOL.1]
FX This study was funded through the Institution-based research (IBR) grant
   of the Tertiary Education Trust Fund (TETFUND) of Nigeria given to
   Usmanu Danfodiyo University Sokoto
   (TETF/DR&D/CE/UNIV/SOKOTO/IBR/2016/VOL.1).
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NR 85
TC 8
Z9 7
U1 0
U2 8
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1420-3049
J9 MOLECULES
JI Molecules
PD JAN
PY 2023
VL 28
IS 2
AR 532
DI 10.3390/molecules28020532
PG 23
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 8Q9YF
UT WOS:000927553100001
PM 36677591
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Wen, L
   Li, MY
   Lin, XJ
   Li, Y
   Song, HD
   Chen, HQ
AF Wen, Ling
   Li, Minyan
   Lin, Xiaojun
   Li, Yan
   Song, Huidong
   Chen, Hanqing
TI AgNPs Aggravated Hepatic Steatosis, Inflammation, Oxidative Stress, and
   Epigenetic Changes in Mice With NAFLD Induced by HFD
SO FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
LA English
DT Article
DE silver nanoparticles; non-alcoholic fatty liver disease; hepatic
   steatosis; global DNA methylation; liver inflammation; hepatotoxicity
ID SILVER NANOPARTICLES; METHYLATION
AB The recent development of silver nanoparticles (AgNPs) has sparked increased interest in biomedical and pharmaceutical applications, leading to the possibility of human exposure. The liver is the primary target organ in the metabolism and transport of nanoparticles. Non-alcoholic fatty liver disease (NAFLD) is the most common and leading cause of hepatic metabolic syndrome with approximately 15% of patients will develop into non-alcoholic steatohepatitis, fibrosis, cirrhosis, and eventually hepatocellular carcinoma. Thus, the potential hepatotoxicity of AgNPs on NAFLD development and progression should be of great concern. Herein, we explored the potential hepatic effect of a single intravenously injected dose of 0.5, 2.5, and 12.5 mg/kg BW on the liver function of high-fat-diet (HFD)-fed mice for 7 days. AgNP treatment increased serum levels of alanine aminotransferase, aspartate transaminase, triglycerides and cholesterols, the number of lipid droplets, and the contents of triglycerides and cholesterols in NAFLD mice livers compared to HFD-fed mice. The mechanism of AgNP-induced worsen hepatotoxicity in mice is associated with hyperactivation of SREBP-1c-mediated de novo lipogenesis and liver inflammation. Additionally, HFD-fed mice treated with AgNPs had significantly higher oxidative damage and lower global DNA methylation and DNA hydroxymethylation than NAFLD mice. This study suggests that AgNP treatment exacerbated HFD-induced hepatic steatosis, liver inflammation, oxidative stress, and epigenetic changes in mice, which is relevant to the risk of AgNP exposure on NAFLD development and progression.
C1 [Wen, Ling; Li, Minyan; Li, Yan; Song, Huidong] Guangzhou Twelfth Peoples Hosp, Guangzhou, Peoples R China.
   [Lin, Xiaojun] Guangzhou Med Univ, Guangzhou Peoples Hosp 12, Dept Gastroenterol, Guangzhou, Peoples R China.
   [Chen, Hanqing] South China Univ Technol, Guangzhou Peoples Hosp 1, Guangzhou Digest Dis Ctr, Sch Med,Dept Gastroenterol, Guangzhou, Peoples R China.
C3 Guangzhou Medical University; South China University of Technology
RP Song, HD (corresponding author), Guangzhou Twelfth Peoples Hosp, Guangzhou, Peoples R China.; Chen, HQ (corresponding author), South China Univ Technol, Guangzhou Peoples Hosp 1, Guangzhou Digest Dis Ctr, Sch Med,Dept Gastroenterol, Guangzhou, Peoples R China.
EM 2354412112@qq.com; eyhanqingchen@scut.edu.cn
RI Chen, Hanqing/GLN-5182-2022
OI Chen, Hanqing/0000-0001-5442-2071
FU National Natural Science Foundation of China [32171370, 11505193];
   Natural Science Foundation of Guangdong Province [2022A1515010415];
   Research Foundation of Guangzhou First Peoples Hospital [KY09040029]
FX This study was supported by the National Natural Science Foundation of
   China (32171370 and 11505193), the Natural Science Foundation of
   Guangdong Province (2022A1515010415), and the Research Foundation of
   Guangzhou First Peoples Hospital (KY09040029).
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NR 42
TC 19
Z9 20
U1 1
U2 21
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-4185
J9 FRONT BIOENG BIOTECH
JI Front. Bioeng. Biotechnol.
PD MAY 19
PY 2022
VL 10
AR 912178
DI 10.3389/fbioe.2022.912178
PG 13
WC Biotechnology & Applied Microbiology; Engineering, Biomedical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Engineering
GA 1W9VG
UT WOS:000807113700001
PM 35677306
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Lee, JH
   Jung, SB
   Lee, SE
   Kim, JE
   Kim, JT
   Kang, YE
   Kang, SG
   Yi, HS
   Ko, YB
   Lee, KH
   Ku, BJ
   Shong, M
   Kim, HJ
AF Lee, Ju Hee
   Jung, Saet-Byel
   Lee, Seong Eun
   Kim, Ji Eun
   Kim, Jung Tae
   Kang, Yea Eun
   Kang, Seul Gi
   Yi, Hyon-Seung
   Ko, Young Bok
   Lee, Ki Hwan
   Ku, Bon Jeong
   Shong, Minho
   Kim, Hyun Jin
TI Expression of LONP1 Is High in Visceral Adipose Tissue in
   Obesity, and Is Associated with Glucose and Lipid Metabolism
SO ENDOCRINOLOGY AND METABOLISM
LA English
DT Article
DE Intra-abdominal fat; Obesity; Metabolic syndrome
ID UNFOLDED PROTEIN RESPONSE; MITOCHONDRIAL-FUNCTION
AB Background: The nature and role of the mitochondrial stress response in adipose tissue in relation to obesity are not yet known. To determine whether the mitochondrial unfolded protein response (UPRmt) in adipose tissue is associated with obesity in humans and rodents.
   Methods: Visceral adipose tissue (VAT) was obtained from 48 normoglyeemic women who underwent surgery. Expression levels of mRNA and proteins were measured for mitochondrial chaperones, intrinsic proteases, and components of electron-transport chains. Furthermore. we systematically analyzed metabolic phenotypes with a large panel of isogenic BXD inbred mouse strains and Genotype-Tissue Expression (GTEx) data.
   Results: In VAT, expression of mitochondrial chaperones and intrinsic proteases localized in inner and outer mitochondrial membranes was not associated with body mass index (BMI), except for the Lon protease homolog, mitochondrial, and the corresponding gene LONP1, which showed high-level expression in the VAT of overweight or obese individuals. Expression of LONP1 in VAT positively correlated with BMI. Analysis of the GTEx database revealed that elevation of LONP1 expression is associated with enhancement of genes involved in glucose and lipid metabolism in VAT Mice with higher Lonp1 expression in adipose tissue had better systemic glucose metabolism than mice with lower Lonp1 expression.
   Conclusion: Expression of mitochondrial LONP1, which is involved in the mitochondrial quality control stress response, was elevated in the VAT of obese individuals. In a bioinformatics analysis, high LONP1 expression in VAT was associated with enhanced glucose and lipid metabolism.
C1 [Lee, Ju Hee; Kang, Yea Eun; Yi, Hyon-Seung; Ku, Bon Jeong; Shong, Minho; Kim, Hyun Jin] Chungnam Natl Univ, Coll Med, Dept Internal Med, 282 Munhwa Ro, Daejeon 35015, South Korea.
   [Lee, Ju Hee; Jung, Saet-Byel; Lee, Seong Eun; Kim, Ji Eun; Kim, Jung Tae; Kang, Yea Eun; Kang, Seul Gi; Yi, Hyon-Seung; Ku, Bon Jeong; Shong, Minho; Kim, Hyun Jin] Chungnam Natl Univ, Coll Med, Res Ctr Endocrine & Metab Dis, Daejeon, South Korea.
   [Ko, Young Bok; Lee, Ki Hwan] Chungnam Natl Univ, Coll Med, Dept Obstet & Gynecol, Daejeon, South Korea.
C3 Chungnam National University; Chungnam National University; Chungnam
   National University
RP Kim, HJ (corresponding author), Chungnam Natl Univ, Coll Med, Dept Internal Med, 282 Munhwa Ro, Daejeon 35015, South Korea.
EM kimjh43@cnuh.co.kr
RI Yi, Hyon-Seung/ABA-2729-2022; Kim, Hyun-Jin/AAJ-2905-2021; shong,
   minho/H-7803-2012
OI Kim, Hyun Jin/0000-0002-6760-4963; Lee, Ju Hee/0000-0001-5976-7175;
   Jung, Saetbyel/0000-0003-2471-8108
FU Korean Diabetes Association, Korea; Basic Science Research Program,
   through the National Research Foundation of Korea (NRF) by the Ministry
   of Science, ICT, Korea [NRF-2020R1C1C1003269]
FX This work was supported by the 2017S-Hyangseol grant (Ju Hee Lee) from
   Korean Diabetes Association, Korea. Ju Hee Lee was supported by the
   Basic Science Research Program, through the National Research Foundation
   of Korea (NRF) by the Ministry of Science, ICT (NRF-2020R1C1C1003269),
   Korea.
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NR 28
TC 10
Z9 11
U1 0
U2 3
PU KOREAN ENDOCRINE SOC
PI SEOUL
PA 101-2503, 109 MAPO-DAERO, MAPO-GU, SEOUL, 04146, SOUTH KOREA
SN 2093-596X
EI 2093-5978
J9 ENDOCRINOL METAB
JI Endocrinol. Metab.
PD JUN
PY 2021
VL 36
IS 3
BP 661
EP 671
DI 10.3803/EnM.2021.1023
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA TB7WP
UT WOS:000668158300021
PM 34154043
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Du, SY
   Lv, Y
   Li, N
   Huang, XX
   Liu, XM
   Li, H
   Wang, C
   Jia, YF
AF Du, Shengye
   Lv, Yan
   Li, Na
   Huang, Xianxia
   Liu, Xuemei
   Li, Hui
   Wang, Chao
   Jia, Yi-Fang
TI Biological investigations on therapeutic effect of chitosan encapsulated
   nano resveratrol against gestational diabetes mellitus rats induced by
   streptozotocin
SO DRUG DELIVERY
LA English
DT Article
DE Gestational diabetes mellitus; chitosan; streptozotocin; resveratrol;
   endoplasmic reticulum stress
ID INSULIN-RESISTANCE; MEDITERRANEAN DIET; METABOLIC SYNDROME;
   ALPHA-AMYLASE; FREE-RADICALS; SUPPLEMENTATION; NANOPARTICLES;
   RESTRICTION; EXPRESSION; HEALTH
AB The chitosan encapsulation with bioactive compounds (resveratrol) is a significant method that can be used to raise the stability and effectiveness of substances in gestational diabetes management. In this study, the resveratrol-zinc oxide complex is encapsulated with chitosan (CS-ZnO-RS). The synthesized CS-ZnO-RS could be used to deliver the resveratrol with minimized side effects and also improved bioavailability. CS-ZnO-RS were characterized by various techniques such as particle size analyzer, DSC, FT-IR, TEM, SEM, and AFM. The electron microscopic and particle analyzer confirmed that the synthesized CS-ZnO-RS were monodispersed, spherical and its average size was 38 nm. The drug-releasing profile showed that 95% of RS is released from CS-ZnO-RS within 24 h.In vitrostudies confirmed that alpha-glucosidase and alpha-amylase inhibitory activities were closely related to the concentration of CS-ZnO-RS. The highest inhibition of alpha-glucosidase (77.32%) and alpha-amylase (78.4%) was observed at 500 mu g/mL. Furthermore, the treatment of CS-ZnO-RS significantly decreased the blood glucose levels in gestational diabetes mellitus induced rats and maintained the lipid content toward the normal rats. In addition, the CS-ZnO-RS reduced the level of inflammation factors (IL-6 and MCP-1) and endoplasmic reticulum stress (GRP78, p-IRE1 alpha, p-eIF2 alpha, and p-PERK).
C1 [Du, Shengye; Huang, Xianxia; Liu, Xuemei; Li, Hui; Wang, Chao] Jinan City Peoples Hosp, Dept Obstet, Jinan, Peoples R China.
   [Lv, Yan] Jinan City Peoples Hosp, Gynecol Reprod Clin, Jinan, Peoples R China.
   [Li, Na] Jinan City Peoples Hosp, Dept Gynecol & Tradit Chinese Med, Jinan, Peoples R China.
   [Jia, Yi-Fang] Shandong First Med Univ, Ctr Prenatal Diag, Shandong Prov Hosp, Jinan, Peoples R China.
C3 Shandong First Medical University & Shandong Academy of Medical Sciences
RP Du, SY (corresponding author), 001 Xuehu St,Changshanbei Rd, Jinan 271100, Shandong, Peoples R China.; Jia, YF (corresponding author), 324 Jingwuweiqi Rd, Jinan 250021, Shandong, Peoples R China.
EM shengye_d@yahoo.com; jyf690629@163.com
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NR 41
TC 38
Z9 40
U1 3
U2 37
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1071-7544
EI 1521-0464
J9 DRUG DELIV
JI Drug Deliv.
PD JAN 1
PY 2020
VL 27
IS 1
BP 953
EP 963
DI 10.1080/10717544.2020.1775722
PG 11
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA MI0EZ
UT WOS:000547092300001
PM 32611265
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Michalsen, A
   Li, CY
AF Michalsen, Andreas
   Li, Chenying
TI Fasting Therapy for Treating and Preventing Disease Current State of
   Evidence
SO FORSCHENDE KOMPLEMENTARMEDIZIN
LA English
DT Review
DE Fasting; Salutogenesis; Chronic diseases; Complementary treatment
ID ATRIAL-NATRIURETIC-PEPTIDE; PITUITARY-GONADAL AXIS; DIETARY RESTRICTION;
   CALORIC RESTRICTION; KETOGENIC DIET; LIFE-SPAN; VEGETARIAN DIET; CHRONIC
   PAIN; RAT-BRAIN; NEUROTROPHIC FACTOR
AB Periods of deliberate fasting with restriction of solid food intake are practiced worldwide, mostly based on traditional, cultural or religious reasons. There is large empirical and observational evidence that medically supervised modified fasting (fasting cure, 200-500 kcal nutritional intake per day) with periods of 7-21 days is efficacious in the treatment of rheumatic diseases, chronic pain syndromes, hypertension, and metabolic syndrome. The beneficial effects of fasting followed by vegetarian diet in rheumatoid arthritis are confirmed by ran domized controlled trials. Further beneficial effects of fasting are supported by observational data and abundant evidence from experimental research which found caloric restriction and intermittent fasting being associated with deceleration or prevention of most chronic degenerative and chronic inflammatory diseases. Intermittent fasting may also be useful as an accompanying treatment during chemotherapy of cancer. A further beneficial effect of fasting relates to improvements in sustainable lifestyle modification and adoption of a healthy diet, possibly mediated by fasting-induced mood enhancement. Various identified mechanisms of fasting point to its potential health-promoting effects, e. g., fasting-induced neuroendocrine activation and hormetic stress response, increased production of neurotrophic factors, reduced mitochondrial oxidative stress, general decrease of signals associated with aging, and promotion of autophagy. Fasting therapy might contribute to the prevention and treatment of chronic diseases and should be further evaluated in controlled clinical trials and observational studies.
C1 [Michalsen, Andreas; Li, Chenying] Charite, Inst Social Med Epidemiol & Hlth Econ, D-13353 Berlin, Germany.
   [Michalsen, Andreas] Immanuel Hosp, Dept Internal & Complementary Med, Berlin, Germany.
   [Li, Chenying] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Tradit Chinese Med, Guangzhou 510275, Guangdong, Peoples R China.
C3 Berlin Institute of Health; Free University of Berlin; Humboldt
   University of Berlin; Charite Universitatsmedizin Berlin; Sun Yat Sen
   University
RP Michalsen, A (corresponding author), Charite, Immanuel Krankenhaus Berlin, Konigstr 63, D-14109 Berlin, Germany.
EM a.michalsen@immanuel.de
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NR 125
TC 91
Z9 98
U1 1
U2 65
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1661-4119
EI 1661-4127
J9 FORSCH KOMPLEMENTMED
JI Forsch. Komplement.med.
PY 2013
VL 20
IS 6
BP 444
EP 453
DI 10.1159/000357765
PG 10
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA 296NT
UT WOS:000330192500006
PM 24434759
DA 2025-06-11
ER

PT J
AU Christodoulou, A
   Christophi, CA
   Sotos-Prieto, M
   Moffatt, S
   Zhao, LG
   Kales, SN
   Hébert, JR
AF Christodoulou, Andria
   Christophi, Costas A.
   Sotos-Prieto, Mercedes
   Moffatt, Steven
   Zhao, Longgang
   Kales, Stefanos N.
   Hebert, James R.
TI The dietary inflammatory index and cardiometabolic parameters in US
   firefighters
SO FRONTIERS IN NUTRITION
LA English
DT Article
DE DII scores; cardiovascular disease; US firefighters; nutrition;
   inflammatory index
ID HIGH-CARDIOVASCULAR-RISK; ASSOCIATION; OBESITY
AB Introduction Dietary choices play a crucial role in influencing systemic inflammation and the eventual development of cardiovascular diseases (CVD). The Dietary Inflammatory Index (DII (R)) is a novel tool designed to assess the inflammatory potential of one's diet. Firefighting, which is characterized by high-stress environments and elevated CVD risk, represents an interesting context for exploring the dietary inflammatory-CVD connection.Aim This study aims to investigate the associations between Energy-adjusted Dietary Inflammatory Index (E-DII (TM)) scores and cardiometabolic risk parameters among US firefighters.Methods The study analyzed 413 participants from the Indianapolis Fire Department who took part in a Federal Emergency Management Agency (FEMA)-sponsored Mediterranean diet intervention trial. Thorough medical evaluations, encompassing physical examinations, standard laboratory tests, resting electrocardiograms, and submaximal treadmill exercise testing, were carried out. Participants also completed a detailed food frequency questionnaire to evaluate dietary patterns, and E-DII scores were subsequently computed based on the gathered information.Results Participants had a mean body mass index (BMI) of 30.0 +/- 4.5 kg/m2 and an average body fat percentage of 28.1 +/- 6.6%. Regression analyses, adjusted for sex, BMI, maximal oxygen consumption (VO2 max), max metabolic equivalents (METS), age, and body fat percentage, revealed significant associations between high vs. low E-DII scores and total cholesterol (beta = 10.37, p = 0.04). When comparing low Vs median E-DII scores there is an increase in glucose (beta = 0.91, p = 0.72) and total cholesterol (beta = 5.51, p = 0.26).Conclusion Our findings support an association between higher E-DII scores and increasing adiposity, as well as worse lipid profiles.
C1 [Christodoulou, Andria; Christophi, Costas A.] Cyprus Univ Technol, Cyprus Int Inst Environm & Publ Hlth, Limassol, Cyprus.
   [Christophi, Costas A.; Sotos-Prieto, Mercedes; Kales, Stefanos N.] Harvard TH Chan Sch Publ Hlth, Dept Environm Hlth, Boston, MA USA.
   [Sotos-Prieto, Mercedes] Univ Autonoma Madrid, Sch Med, Dept Prevent Med & Publ Hlth, Madrid, Spain.
   [Sotos-Prieto, Mercedes] Carlos III Hlth Inst, Biomed Res Network Ctr Epidemiol & Publ Hlth CIBER, Madrid, Spain.
   [Sotos-Prieto, Mercedes] CEI UAM CSIC, IMDEA Food Inst, Madrid, Spain.
   [Moffatt, Steven] Natl Inst Publ Safety Hlth, Indianapolis, IN USA.
   [Zhao, Longgang; Hebert, James R.] Univ South Carolina, Arnold Sch Publ Hlth, Dept Epidemiol & Biostat, Columbia, SC USA.
   [Zhao, Longgang; Hebert, James R.] Univ South Carolina, Arnold Sch Publ Hlth, Canc Prevent & Control Program, Columbia, SC USA.
   [Zhao, Longgang; Hebert, James R.] Connecting Hlth Innovat LLC, Columbia, SC USA.
   [Kales, Stefanos N.] Cambridge Hlth Alliance, Dept Occupat Med, Cambridge, MA USA.
   [Kales, Stefanos N.] Harvard Med Sch, Cambridge, MA USA.
C3 Cyprus International Institute for Environmental & Public Health; Cyprus
   University of Technology; Harvard University; Harvard T.H. Chan School
   of Public Health; Autonomous University of Madrid; Consejo Superior de
   Investigaciones Cientificas (CSIC); IMDEA Food Institute; University of
   South Carolina System; University of South Carolina Columbia; University
   of South Carolina System; University of South Carolina Columbia;
   Connecting Health Innovations LLC; Harvard University; Harvard
   University Medical Affiliates; Cambridge Health Alliance
RP Christodoulou, A (corresponding author), Cyprus Univ Technol, Cyprus Int Inst Environm & Publ Hlth, Limassol, Cyprus.
EM at.christodoulou@edu.cut.ac.cy
RI Hebert, James/IUO-5628-2023; Zhao, Longgang/ABB-9175-2021; PRIETO,
   MERCEDES/F-9180-2013
FU US Department of Homeland Security, Ohio University OURC grant
   [EMW-2014-FP-00612]; CHSP Research Innovation grant; Southeast Center
   for Integrated Metabolomics Pilot and Feasibility Project; Ramon y Cajal
   Ministry of Science, Innovation and Universities [RYC-2018-025069-I];
   FEDER/FSE [PI20/00896]; FIS [PI20/00896]
FX The author(s) declare that financial support was received for the
   research, authorship, and/or publication of this article. This research
   was funded by EMW-2014-FP-00612, US Department of Homeland Security,
   Ohio University OURC grant, CHSP Research Innovation grant, and the 2018
   Southeast Center for Integrated Metabolomics Pilot and Feasibility
   Project. MS-P holds a Ramon y Cajal contract (RYC-2018-025069-I) from
   the Ministry of Science, Innovation and Universities and FEDER/FSE and
   FIS grant PI20/00896. The funding agencies had no role in study design,
   data collection and analysis, interpretation of results, manuscript
   preparation or in the decision to submit this manuscript for
   publication.
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NR 54
TC 0
Z9 0
U1 1
U2 4
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD JUN 13
PY 2024
VL 11
AR 1382306
DI 10.3389/fnut.2024.1382306
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA WM1U9
UT WOS:001255203200001
PM 38938668
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Timpka, S
   Melander, O
   Engström, G
   Elmståhl, S
   Nilsson, PM
   Lind, L
   Pihlsgård, M
   Enhörning, S
AF Timpka, Simon
   Melander, Olle
   Engstrom, Gunnar
   Elmstahl, Solve
   Nilsson, Peter M.
   Lind, Lars
   Pihlsgard, Mats
   Enhorning, Sofia
TI Short-term association between outdoor temperature and the
   hydration-marker copeptin: a pooled analysis in five cohorts
SO EBIOMEDICINE
LA English
DT Article
DE Cold environment; Heat; Temperature-related morbidity; Water intake;
   Vasopressin; Climate change; Copeptin
ID MORTALITY; VASOPRESSIN; DISEASE; WATER; COLD; STRESS; RISK
AB Background Whereas outdoor temperature is linked to both mortality and hydration status, the hormone vasopressin, measured through the surrogate copeptin, is a marker of cardiometabolic risk and hydration. We recently showed that copeptin has a seasonal pattern with higher plasma concentration in winter. Here, we aimed to investigate the as-sociation between outdoor temperature and copeptin.Methods Copeptin was analysed in fasting plasma from five cohorts in Malmu, Sweden (n = 26,753, 49.7% men, age 18-86 years). We utilized a multivariable adjusted non-linear spline model with four knots to investigate the association between short-term temperature (24 h mean apparent) and log copeptin z-score.Findings We found a distinct non-linear association between temperature and log copeptin z-score, with both moderately low and high temperatures linked to higher copeptin concentration (p < 0.0001). Between 0 C-degrees and nadir at the 75th temperature percentile (corresponding to 14.3 degrees C), log copeptin decreased 0.13 z-scores (95% CI 0.096; 0.16), which also inversely corresponded to the increase in z-score log copeptin between the nadir and 21.3 C-degrees. Interpretation The J-shaped association between short-term temperature and copeptin resembles the J-shaped association between temperature and mortality. Whereas the untangling of temperature from other seasonal effects on hydration warrants further study, moderately increased water intake constitutes a feasible intervention to lower vasopressin and might mitigate adverse health effects of both moderately cold and hot outdoor temperatures.Funding Swedish Research Council, A Wiberg, M Stephen, A Pahlsson, Crafoord and Swedish Heart-Lung Foun-dations, Swedish Society for Medical Research and Swedish Society of Medicine.
C1 [Timpka, Simon; Enhorning, Sofia] Lund Univ, Diabet Ctr, Dept Clin Sci Malmo, Perinatal & Cardiovasc Epidemiol, Malmo, Sweden.
   [Timpka, Simon] Skane Univ Hosp, Dept Obstet & Gynecol, Malmo, Sweden.
   [Melander, Olle] Lund Univ, Dept Clin Sci Malmo, Malmo, Sweden.
   [Melander, Olle; Enhorning, Sofia] Skane Univ Hosp, Dept Internal Med, Malmo, Sweden.
   [Elmstahl, Solve] Lund Univ, Dept Clin Sci Malmo, Div Geriatr Med, Malmo, Sweden.
   [Nilsson, Peter M.] Lund Univ, Dept Clin Sci Malmo, Internal Med Epidemiol, Malmo, Sweden.
   [Lind, Lars] Uppsala Univ, Dept Med Sci, Uppsala, Sweden.
   [Enhorning, Sofia] Skane Univ Hosp, Clin Res Ctr, Perinatal & Cardiovasc Epidemiol, Jan Waldenstroms Gata 35 91-12, S-21428 Malmo, Sweden.
C3 Lund University; Lund University; Skane University Hospital; Lund
   University; Lund University; Skane University Hospital; Lund University;
   Lund University; Uppsala University; Lund University; Skane University
   Hospital
RP Enhörning, S (corresponding author), Skane Univ Hosp, Clin Res Ctr, Perinatal & Cardiovasc Epidemiol, Jan Waldenstroms Gata 35 91-12, S-21428 Malmo, Sweden.
RI Timpka, Simon/ABG-2173-2020; Lind, Lars/KAM-1968-2024
OI Timpka, Simon/0000-0001-7445-7212; Engstrom, Gunnar/0000-0002-8618-9152;
   Enhorning, Sofia/0000-0001-8895-0534; Melander, Olle/0000-0002-2581-484X
FU Swedish Research Council; A Wiberg Foundation; M Stephen Foundation; A
   Pahlsson Foundation; Crafoord Foundation; Swedish Heart-Lung Foundation;
   Swedish Society for Medical Research; Swedish Society of Medicine
FX Swedish Research Council, A Wiberg, M Stephen, A Pahlsson, Crafoord and
   Swedish Heart-Lung Foundations, Swedish Society for Medical Research and
   Swedish Society of Medicine
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NR 36
TC 2
Z9 2
U1 0
U2 1
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2352-3964
J9 EBIOMEDICINE
JI EBioMedicine
PD SEP
PY 2023
VL 95
AR 104750
DI 10.1016/j.ebiom.2023.104750
EA AUG 2023
PG 8
WC Medicine, General & Internal; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Research & Experimental Medicine
GA R2OF9
UT WOS:001062786700001
PM 37556945
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Karthiga, K
   Pal, GK
   Dasari, P
   Nanda, N
   Velkumary, S
   Chinnakali, P
AF Karthiga, Kuzhanthaivelu
   Pal, Gopal Krushna
   Dasari, Papa
   Nanda, Nivedita
   Velkumary, Subramanian
   Chinnakali, Palanivel
TI Attenuation of baroreflex sensitivity and heart rate variability is
   linked to reduced levels of nitric oxide in pregnant women having risks
   of developing gestational hypertension
SO CLINICAL AND EXPERIMENTAL HYPERTENSION
LA English
DT Article
DE Gestational hypertension; nitric oxide; sympathovagal imbalance;
   cardiovascular risk; interleukin-6
AB Purpose: Decreased baroreflex sensitivity (BRS) and sympathovagal imbalance (SVI) have been reported as a cardiovascular (CV) risk in gestational hypertension (GH). Nitric oxide (NO) has been implicated in pathophysiology of GH. In the present study, we assessed the link of CV risks (decreased BRS and SVI) to the plasma levels of NO in women having risk of developing GH. Materials and Methods: A total of 96 pregnant women having risk factors for GH were recruited for the study. The blood pressure variability (BPV), heart rate variability (HRV), plasma NO, marker of insulin resistance (HOMA-IR), lipid risk factors, inflammatory markers (hsCRP, interleukin-6), and malondialdehyde (MDA), the marker of oxidative stress (OS) were measured at 16(th) and 36(th) week. Link of various parameters to NO was assessed by correlation and multiple regression analysis. Results: Of HRV indices, parasympathetic components were decreased and sympathetic components were increased, BRS was decreased, NO was decreased, HOMA-IR, lipid risk factors, hsCRP, interleukin-6, and MDA were increased significantly at 36(th) week compared to 16(th) week of pregnancy. Most of the markers of cardiometabolic risk were correlated with NO. However, only the markers of CV risk (SVI and reduced BRS) were independently associated with decreased level of NO, but not the metabolic markers except interleukin-6. The independent contribution of BRS (beta = 0.334, P < .001) to NO was found to be most significant. Conclusion: It was concluded that decreased BRS, SVI, and increased interleukin-6 are associated with reduction in NO in GH, which may possibly be linked to the development of CV risks in GH.
C1 [Karthiga, Kuzhanthaivelu; Pal, Gopal Krushna; Velkumary, Subramanian] JIPMER, Dept Physiol, Pondicherry 605006, India.
   [Dasari, Papa] JIPMER, Dept Obstet & Gynecol, Pondicherry, India.
   [Nanda, Nivedita] JIPMER, Dept Biochem, Pondicherry, India.
   [Chinnakali, Palanivel] JIPMER, Dept Prevent & Social Med, Pondicherry, India.
C3 Jawaharlal Institute of Postgraduate Medical Education & Research;
   Jawaharlal Institute of Postgraduate Medical Education & Research;
   Jawaharlal Institute of Postgraduate Medical Education & Research;
   Jawaharlal Institute of Postgraduate Medical Education & Research
RP Pal, GK (corresponding author), JIPMER, Dept Physiol, Pondicherry 605006, India.
EM drgkpal@gmail.com
RI Chinnakali, Palanivel/N-8659-2013; Subramanian, Velkumary/IUQ-6299-2023;
   Dasari, Papa/AGS-0983-2022; Nanda, Nivedita/P-6453-2014
OI Chinnakali, Palanivel/0000-0001-8320-1016; Nanda,
   Nivedita/0000-0002-8887-8357
FU JIPMER, Puducherry
FX Authors acknowledge the support given by JIPMER, Puducherry, for the
   first author as part of her PhD Intramural Research Fund.
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NR 44
TC 6
Z9 8
U1 0
U2 5
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1064-1963
EI 1525-6006
J9 CLIN EXP HYPERTENS
JI Clin. Exp. Hypertens.
PD MAY 19
PY 2021
VL 43
IS 4
BP 356
EP 362
DI 10.1080/10641963.2021.1883053
EA FEB 2021
PG 7
WC Pharmacology & Pharmacy; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Cardiovascular System & Cardiology
GA QX0DX
UT WOS:000617224400001
PM 33567918
DA 2025-06-11
ER

PT J
AU Garay-Sevilla, ME
   Torres-Graciano, S
   Villegas-Rodríguez, ME
   Rivera-Cisneros, AE
   Wrobel, K
   Uribarri, J
AF Eugenia Garay-Sevilla, Ma.
   Torres-Graciano, Sofia
   Etzabel Villegas-Rodriguez, Ma.
   Rivera-Cisneros, Antonio E.
   Wrobel, Katarzyna
   Uribarri, Jaime
TI Advanced glycation end products and their receptors did not show any
   association with body mass parameters in metabolically healthy
   adolescents
SO ACTA PAEDIATRICA
LA English
DT Article
DE Adolescents; Advanced glycation end products; Insulin resistance;
   Metabolically healthy obese; Soluble receptor for advanced glycation end
   products
ID CARDIOMETABOLIC RISK MARKERS; HOMEOSTASIS MODEL ASSESSMENT;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; AGE RECEPTOR-1; OBESE CHILDREN;
   NORMAL-WEIGHT; INFLAMMATION; RESTRICTION; OVERWEIGHT
AB Aim We determined the relationship between circulating advanced glycation end products (AGEs), AGE receptors and homeostatic model assessment for insulin resistance (HOMA-IR) in metabolically healthy obese and normal weight adolescents. Methods Results In 2015, we recruited 80 normal weight adolescents and 80 with obesity from schools Leon city, Mexico, and put them into metabolically healthy (HOMA-IR <3.0) and unhealthy (HOMA-IR >3.0) groups. We measured their body mass index (BMI) and carried out detailed blood analyses. We found a higher triglycerides, triglycerides/high-density lipoproteins cholesterol (TG/HDL-C) index, HOMA-IR, tumour necrosis factor alpha (TNF-alpha) and interleukin-6 (IL-6) in the metabolically healthy group and found correlations between HOMA-IR with BMI, the TG/HDL-C index and IL-6 and the TG/HDL-C index and BMI and (TNF-alpha). There was no correlation between markers of obesity and circulating N-carboxymethyl-lysine (CML) or soluble receptor for advanced glycation end products (sRAGE). Some unhealthy adolescents had higher CML (15.5 +/- 2.7 U/mL, p < 0.028) and sRAGE (3123 +/- 1364 pg/mL, p < 0.001) than the healthy group. Conclusion HOMA-IR and the TG/HDL-C index were associated with BMI and inflammation markers. CML and sRAGE were not associated with obesity or inflammation. These parameters were higher in unhealthy obese adolescents.
C1 [Eugenia Garay-Sevilla, Ma.; Torres-Graciano, Sofia; Etzabel Villegas-Rodriguez, Ma.] Univ Guanajuato Campus, Div Hlth Sci, Dept Med Sci, 20 Enero 929,Col Obregon, Leon, Guanajuato, Mexico.
   [Rivera-Cisneros, Antonio E.] Univ Autonoma Guadalajara, Pachuca, Mexico.
   [Rivera-Cisneros, Antonio E.] Univ Futbol & Deporte, Pachuca, Mexico.
   [Wrobel, Katarzyna] Univ Guanajuato, Dept Chem, Guanajuato, Mexico.
   [Uribarri, Jaime] Icahn Sch Med Mt Sinai, Dept Med, New York, NY 10029 USA.
C3 Universidad Autonoma de Guadalajara; Universidad de Guanajuato; Icahn
   School of Medicine at Mount Sinai
RP Garay-Sevilla, ME (corresponding author), Univ Guanajuato Campus, Div Hlth Sci, Dept Med Sci, 20 Enero 929,Col Obregon, Leon, Guanajuato, Mexico.
EM marugaray_2000@yahoo.com
RI Uribarri, Jaime/ADX-7655-2022; Wrobel, Katarzyna/AFL-8445-2022
OI uribarri, jaime/0000-0001-9826-1134; Wrobel,
   Katarzyna/0000-0001-5623-7312
FU CONACYT Mexico [FOMIX GTO-2012-C03-195211]
FX This study was partially supported by funds from CONACYT Mexico (FOMIX
   GTO-2012-C03-195211).
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NR 30
TC 8
Z9 8
U1 0
U2 8
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0803-5253
EI 1651-2227
J9 ACTA PAEDIATR
JI Acta Paediatr.
PD DEC
PY 2018
VL 107
IS 12
BP 2146
EP 2151
DI 10.1111/apa.14426
PG 6
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA GZ7DU
UT WOS:000449638100021
PM 29846968
DA 2025-06-11
ER

PT J
AU Grizzanti, J
   Lee, HG
   Camins, A
   Pallas, M
   Casadesus, G
AF Grizzanti, John
   Lee, Hyoung-Gon
   Camins, Antoni
   Pallas, Merce
   Casadesus, Gemma
TI The therapeutic potential of metabolic hormones in the treatment of
   age-related cognitive decline and Alzheimer's disease
SO NUTRITION RESEARCH
LA English
DT Review
DE Diabetes; Obesity; Alzheimer disease; Insulin; Leptin; Amylin
ID INSULIN-DEGRADING ENZYME; DIET-INDUCED OBESITY; BODY-MASS INDEX;
   ISLET-AMYLOID POLYPEPTIDE; GROWTH-FACTOR EXPRESSION; TRANSGENIC MOUSE
   MODEL; CENTRAL-NERVOUS-SYSTEM; BLOOD-BRAIN-BARRIER; OXIDATIVE STRESS;
   A-BETA
AB Aging leads to a number of physiological alterations, specifically changes in circulating hormone levels, increases in fat deposition, decreases in metabolism, changes in inflammatory responses, and reductions in growth factors. These progressive changes in physiology and metabolism are exacerbated by modern culture and Western diet and give rise to diseases such as obesity, metabolic syndrome, and type 2 (non-insulin-dependent) diabetes (T2D). These age and lifestyle-related metabolic diseases are often accompanied by insulin and leptin resistance, as well as aberrant amylin production and signaling. Many of these alterations in hormone production and signaling are directly influenced by an increase in both oxidative stress and inflammation. Importantly, changes in hormone production and signaling have direct effects on brain function and the development of age-related neurologic disorders. Therefore, this review aims to present evidence on the effects that diet and metabolic disease have on age-related cognitive decline and the development of cognitive diseases, particularly Alzheimer disease. This review will focus on the metabolic hormones insulin, leptin, and amylin and their role in cognitive decline, as well as the therapeutic potential of these hormones in treating cognitive disease. Future investigations targeting the long-term effects of insulin and leptin treatment may reveal evidence to reduce risk of cognitive decline and Alzheimer disease. (C) 2016 Published by Elsevier Inc.
C1 [Grizzanti, John; Casadesus, Gemma] Kent State Univ, Sch Biomed Sci, Kent, OH 44242 USA.
   [Casadesus, Gemma] Kent State Univ, Dept Biol Sci, 256 Cunningham Hall, Kent, OH 44242 USA.
   [Lee, Hyoung-Gon] Univ Texas San Antonio, Dept Biol, San Antonio, TX USA.
   [Camins, Antoni; Pallas, Merce] Univ Barcelona, Dept Pharmacol & Therapeut Chem, Barcelona, Spain.
C3 University System of Ohio; Kent State University; Kent State University
   Salem; Kent State University Kent; University System of Ohio; Kent State
   University; Kent State University Salem; Kent State University Kent;
   University of Texas System; University of Texas at San Antonio (UTSA);
   University of Barcelona
RP Casadesus, G (corresponding author), Kent State Univ, Dept Biol Sci, 256 Cunningham Hall, Kent, OH 44242 USA.
EM Gcasades@kent.edu
RI Lee, Hyoung-gon/A-9637-2009; Camins, Antonio/J-5126-2019
OI Camins, Antoni/0000-0002-1229-5956; Lee, Hyoung-gon/0000-0003-1786-8319;
   Casadesus, Gemma/0000-0002-5206-5637; Grizzanti,
   John/0000-0003-4542-8660
FU National Institutes of Aging [1R15AG050292]; Alzheimer's Association
   [NPSPAD 247219]
FX The authors thank Jeffrey A. Blair and Sabina Bhatta for their
   assistance in proofreading, editing, and formatting this review. This
   work was supported by the National Institutes of Aging (Grant No.
   1R15AG050292) and the Alzheimer's Association (Grant No. NPSPAD 247219).
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NR 162
TC 17
Z9 18
U1 0
U2 21
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0271-5317
EI 1879-0739
J9 NUTR RES
JI Nutr. Res.
PD DEC
PY 2016
VL 36
IS 12
BP 1305
EP 1315
DI 10.1016/j.nutres.2016.11.002
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA EG5KN
UT WOS:000391082800001
PM 27923524
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Fülöp, P
   Harangi, M
   Seres, I
   Paragh, G
AF Fulop, Peter
   Harangi, Mariann
   Seres, Ildiko
   Paragh, Gyorgy
TI Paraoxonase-1 and adipokines: Potential links between obesity and
   atherosclerosis
SO CHEMICO-BIOLOGICAL INTERACTIONS
LA English
DT Article; Proceedings Paper
CT 12th International Meeting on Cholinesterases / 6th International
   Conference on Paraoxonase
CY 2015
CL Elche, SPAIN
DE Paraoxonase-1; Adipokines; Atherosclerosis; White adipose tissue;
   Fine-tuning
ID C-REACTIVE PROTEIN; OXIDATIVE STRESS; SERUM PARAOXONASE; METABOLIC
   SYNDROME; NONDIABETIC OBESE; PON1 ACTIVITY; LEPTIN; PLASMA;
   INFLAMMATION; ADIPONECTIN
AB Oxidative stress and chronic low-grade inflammation are major characteristics of obesity-related disorders. The dominance of pro-oxidant and pro-inflammatory mechanisms triggers insulin resistance and enhances the progression of atherosclerosis. Discovered first as an esterase that hydrolyze organophosphates, human paraoxonase-1 is bound to high-density lipoprotein and inhibits the oxidation of lipoproteins and reduces the degree of inflammation, hence it is considered to act against atherosclerosis. In contrast, the majority of the adipokines secreted from the enlarged white adipose tissue promote the atherosclerotic process; and altered adipokine secretion is now regarded as one of the major contributors of increased cardiovascular morbidity and mortality in obesity. In this review, we detail the correlations between paraoxonase-1 and some selected adipokines, namely leptin, adiponectin and chemerin. Adipokine imbalance leads to decreased paraoxonase-1 activity that results in enhanced atherosclerosis; therefore, altered adipokine secretion may be predictive of cardiovascular complications in obesity. As an active organ secreting biological active substances, white adipose tissue may also act as a "fine-tuner" of immune and endocrine actions attenuating or enhancing reactions triggered by pathogens, inflammation and metabolic stimuli; and obesity, as a chronic noxious state may perturb the proper functioning of this fine-tuning process. Further investigations are of major importance to elucidate the associations between adipokines and paraoxonase-1 and to establish accurate interventions against obesity-related disorders. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
C1 [Fulop, Peter; Harangi, Mariann; Seres, Ildiko; Paragh, Gyorgy] Univ Debrecen, Inst Internal Med, Div Metab Dis, Fac Med, Nagyerdei Krt 98, H-4032 Debrecen, Hungary.
C3 University of Debrecen
RP Paragh, G (corresponding author), Univ Debrecen, Inst Internal Med, Div Metab Dis, Fac Med, Nagyerdei Krt 98, H-4032 Debrecen, Hungary.
EM pfulop@belklinika.com; mharangi@hotmail.com; seres@belklinika.com;
   paragh@belklinika.com
RI Harangi, Mariann/ACY-2278-2022
OI Harangi, Mariann/0000-0001-9761-9595
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NR 46
TC 24
Z9 24
U1 1
U2 18
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0009-2797
EI 1872-7786
J9 CHEM-BIOL INTERACT
JI Chem.-Biol. Interact.
PD NOV 25
PY 2016
VL 259
SI SI
BP 388
EP 393
DI 10.1016/j.cbi.2016.04.003
PN B
PG 6
WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology
GA ED4TC
UT WOS:000388843500048
PM 27062889
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Hill, EE
   Eisenmann, JC
   Gentile, D
   Holmes, ME
   Walsh, D
AF Hill, Emily E.
   Eisenmann, Joey C.
   Gentile, Douglas
   Holmes, Megan E.
   Walsh, David
TI The association between morning cortisol and adiposity in children
   varies by weight status
SO JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
LA English
DT Article
DE hypothalamic-pituitary-adrenal axis; obesity; overweight; stress;
   visceral fatness
ID METABOLIC SYNDROME; SALIVARY CORTISOL; OBESITY; STRESS; TISSUE;
   OVERWEIGHT; RHYTHMS; GIRLS; BOYS; MASS
AB Objective: To examine the associations between morning cortisol and adiposity in children at baseline and 9-month follow-up.
   Methods: Participants included 649 (301 males, 348 females) children (9.6+/-0.9 years) for the cross-sectional analysis and 316 (153 males, 163 females) for the longitudinal analysis. Body mass index (BMI, kg/m(2)) was calculated from measured height and weight and waist circumference (WC, cm) was measured at the superior border of the iliac crest. Cortisol was assessed via saliva samples collected on a single morning. Cross-sectional and longitudinal analyses were conducted to examine the relationships between cortisol and adiposity.
   Results: Approximately 31% were overweight (17.7%) or obese (12.8%). The mean cortisol level was 9.36+/-5.64 nmol/L (0.34+/-0.20 mu g/dL). At baseline, no significant correlations were found between cortisol and BMI or WC (r<0.07). Baseline cortisol did not correlate with change in BMI z-score (r=-0.03) or WC (r<-0.01) over the follow-up period. When examined by weight status, baseline cortisol was significantly related to changes in WC (r=0.32) and BMI z-score (r=0.28) among overweight subjects.
   Conclusions: A positive relationship was found between morning cortisol and change in WC over 9 months in overweight children. Future studies should examine the association between 24-h cortisol patterns and direct measures of trunk fat.
C1 [Hill, Emily E.; Eisenmann, Joey C.; Holmes, Megan E.] Michigan State Univ, Dept Kinesiol, E Lansing, MI 48824 USA.
   [Gentile, Douglas] Iowa State Univ, Dept Psychol, Ames, IA USA.
   [Walsh, David] Mind Posit Parenting, Minneapolis, MN USA.
C3 Michigan State University; Iowa State University
RP Eisenmann, JC (corresponding author), Helen DeVos Childrens Hosp, Women & Childrens Ctr D129, Mailcode 011,330 Barclay NE, Grand Rapids, MI 49503 USA.
EM Joey.Eisenmann@helendevoschildrens.org
RI Holmes, Megan/AAX-6919-2021; Gentile, Douglas/I-7759-2012
OI Holmes, Megan/0000-0003-1716-6122; Gentile, Douglas/0000-0002-5934-2860
FU Medica Foundation; Healthy and Active America Foundation; Fairview
   Health Services; Cargill, Inc.
FX In Lakeville, Minnesota Switch is sponsored by Medica Foundation,
   Healthy and Active America Foundation, and Fairview Health Services. In
   Cedar Rapids, Iowa Switch is sponsored by Cargill, Inc. and the Healthy
   and Active America Foundation. The authors acknowledge and thank all
   members of the Switch intervention team including Lakeville School
   District, Cedar Rapids School District, Linda Swanson, Joe McGillicuddy,
   Jim Paterson, Hal Garwood, Alex Dahlquist, and William Stone III. Switch
   (TM)-active lifestyles from MediaWise (R) is a registered trademark of
   the National Institute on Media and the Family, Minneapolis, MN.
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NR 30
TC 12
Z9 14
U1 0
U2 10
PU WALTER DE GRUYTER GMBH
PI BERLIN
PA GENTHINER STRASSE 13, D-10785 BERLIN, GERMANY
SN 0334-018X
EI 2191-0251
J9 J PEDIATR ENDOCR MET
JI J. Pediatr. Endocrinol. Metab.
PD OCT
PY 2011
VL 24
IS 9-10
BP 709
EP 713
DI 10.1515/JPEM.2011.267
PG 5
WC Endocrinology & Metabolism; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Pediatrics
GA 854BQ
UT WOS:000297470000017
PM 22145461
DA 2025-06-11
ER

PT J
AU Labrecque, B
   Beaudry, D
   Mayhue, M
   Hallé, C
   Bordignon, V
   Murphy, BD
   Palin, MF
AF Labrecque, Benoit
   Beaudry, Daniele
   Mayhue, Marian
   Halle, Catherine
   Bordignon, Vilceu
   Murphy, Bruce D.
   Palin, Marie-France
TI Molecular characterization and expression analysis of the porcine
   paraoxonase 3 (PON3) gene
SO GENE
LA English
DT Article
DE Adipose tissue; Gene expression; Isoform, Paraoxonase 3; Pig; SNP
ID LOW-DENSITY-LIPOPROTEIN; CORONARY-HEART-DISEASE; SERUM PARAOXONASE;
   METABOLIC SYNDROME; OXIDATIVE STRESS; LIPID-METABOLISM; TRANSGENIC MICE;
   ATHEROSCLEROSIS; POLYMORPHISMS; SWINE
AB The paraoxonase (PON) gene family has 3 members, PON1, PON2 and PON3, which are known to be involved in oxidative stress-associated processes such as dyslipidemia, diabetes and coronary heart disease. Although PON3 is the least studied paraoxonase, recent findings have shown that it can significantly reduce atherosclerotic lesion formation and obesity in PON3 transgenic mice. Here, we describe the isolation and molecular characterization of the cDNA encoding the porcine PON3 gene. We also report the cloning of three porcine PON3 transcript variants resulting from alternate splicing of exons. Our results show that PON3 mRNA and protein are ubiquitously expressed in pig tissues. Moreover, the relative abundance of PON3 mRNA, measured in perirenal and subcutaneous fat tissues, is higher in obese Upton Meishan gilts compared with the leaner Large White and Ham Line gilts. PON3 mRNA levels measured in fat tissues positively correlate with subcutaneous. visceral and total body fat weights. Four single nucleotide polymorphisms (SNP) were identified in the PON3 coding sequence. and among these, an association was found between the c.449G>A polymorphism and the longissimus dorsi depth estimated breeding value (EBV) trait. Knowledge of the structure, distribution and expression profile of the porcine PON3 gene provides insights into its physiological function. Our results provide further support for involvement of PON3 in obesity-related disorders. Crown Copyright (C) 2009 Published by Elsevier B.V. All rights reserved.
C1 [Labrecque, Benoit; Beaudry, Daniele; Mayhue, Marian; Halle, Catherine; Palin, Marie-France] Agr & Agri Food Canada, Dairy & Swine Res & Dev Ctr, Sherbrooke, PQ J1M 1Z3, Canada.
   [Labrecque, Benoit; Murphy, Bruce D.] Univ Montreal, Fac Med Vet, Ctr Rech Reprod Anim, St Hyacinthe, PQ J2S 7C6, Canada.
   [Bordignon, Vilceu] McGill Univ, Ste Anne De Bellevue, PQ H9X 3V9, Canada.
C3 Agriculture & Agri Food Canada; Universite de Montreal; McGill
   University
RP Palin, MF (corresponding author), Agr & Agri Food Canada, Dairy & Swine Res & Dev Ctr, 2000 Rue Coll,CP 90, Sherbrooke, PQ J1M 1Z3, Canada.
EM palinmf@agr.gc.ca
RI Bordignon, Vilceu/LTE-8003-2024
OI Bordignon, Vilceu/0000-0001-7076-7707; Murphy, Bruce/0000-0001-7158-3360
FU National Sciences and Engineering Research Council of Canada [322101-05]
FX This work was supported by the National Sciences and Engineering
   Research Council of Canada through Strategic Grant no. 322101-05 made to
   B.D. Murphy, V. Bordignon and M.F. Palin, by Genetiporc Inc.
   (St-Bernard, QC, Canada), by Agriculture and Agri-Food Canada and by
   Hypor (formerly Genex Swine Group, Regina, SK, Canada). The authors are
   grateful to S. Methot for performing the statistical analyses, Professor
   Srinivasa T. Reddy, of the University of California, for providing the
   Ab raised against human PON3 and, to the staff of the Swine Complex for
   animals care. Sherbrooke Dairy and Swine R&D Centre contribution no
   1005.
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NR 66
TC 39
Z9 46
U1 0
U2 4
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-1119
EI 1879-0038
J9 GENE
JI Gene
PD AUG 15
PY 2009
VL 443
IS 1-2
BP 110
EP 120
DI 10.1016/j.gene.2009.04.026
PG 11
WC Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Genetics & Heredity
GA 471UP
UT WOS:000268084100014
PM 19426787
DA 2025-06-11
ER

PT J
AU Alsunbul, M
   El-Masry, TA
   El Zahaby, EI
   Gaballa, MMS
   El-Nagar, MMF
AF Alsunbul, Maha
   El-Masry, Thanaa A.
   El Zahaby, Enas I.
   Gaballa, Mohamed M. S.
   El-Nagar, Maysa M. F.
TI Potential Protective Effect of Orlistat: A Formulation of Nanocrystals
   Targeting Inflammation, Oxidative Stress, and Apoptosis in an
   Experimental Model of Doxorubicin-Induced Cardiotoxicity
SO PHARMACEUTICS
LA English
DT Article
DE cardioprotective; orlistat nanocrystals; oxidative stress; inflammation;
   apoptosis; Sirt-1; Nrf2; HO-1
ID GENE-EXPRESSION; WEIGHT-LOSS; MITOCHONDRIAL; MICE
AB Background: Doxorubicin (DOX) is a widely used chemotherapeutic agent; nevertheless, cardiotoxicity limits its effectiveness. Orlistat (Orli) is an irreversible lipase enzyme inhibitor with poor solubility and bioavailability. Furthermore, Orli has a favorable impact on the decrease in cardiometabolic risk variables. Thus, this study aimed to investigate the novel use of Orlistat Nanocrystals (Orli-Nanocrystals) to mitigate DOX-induced cardiotoxicity and to identify probable pathways behind the cardioprotective effects. Methods: The pharmacokinetic parameters-area under % dose/g heart time curve (AUC0 -> 4h), Drug targeting index (DTI), and relative targeting efficiency (RTE)-were calculated. Furthermore, experimental design mice were categorized into six groups: a (1) Normal control group, (2) Orli-Free group, (3) Orli-Nanocrystals group, (4) DOX group, (5) Orli-Free-DOX group, and (6) Orli-Nanocrystals-DOX group. All treatments were intraperitoneally injected once daily for 14 days with a single dose of DOX (15 mg/kg) on the 12th day for 4, 5, and 6 groups. Results: The pharmacokinetic parameters (Cmax, AUC) following oral administration of Orli-Nanocrystals presented a significant difference (higher values) in comparison to Orli due to the enhanced extent of the absorption of nanocrystals and, subsequently, their distribution to the heart. The study results indicated that DOX caused significant cardiotoxicity, as revealed by a remarkable rise in cardiac function biomarkers like LDH and CK-MB, which involve enzyme activities. Additionally, cardiac MDA content also increased; however, glutathione peroxidase, catalase, and superoxide dismutase activities were decreased. In the same context, DOX was found to have a remarkable downregulation in Nrf2, HO-1, Sirt-1, and Bcl2, while the upregulation of NF-kappa B, TNF-alpha, and BAX gene and protein expression occurred. Pretreatment with Orli-Nanocrystals displayed the most notable recovery of the altered immunohistochemical, histological, and biochemical characteristics as compared to the Orli-Free group. Conclusions: This work is the first investigation into the potential use of antioxidant, anti-inflammatory, and anti-apoptotic characteristics of Orli-Nanocrystals to protect against DOX-induced cardiotoxicity in vivo.
C1 [Alsunbul, Maha] Princess Nourah bint Abdulrahman Univ, Coll Pharm, Dept Pharmaceut Sci, POB 84428, Riyadh 11671, Saudi Arabia.
   [El-Masry, Thanaa A.; El-Nagar, Maysa M. F.] Tanta Univ, Fac Pharm, Dept Pharmacol & Toxicol, Tanta 31527, Egypt.
   [El Zahaby, Enas I.] Delta Univ Sci & Technol, Fac Pharm, Dept Pharmaceut, Gamasa 35712, Egypt.
   [Gaballa, Mohamed M. S.] Benha Univ, Fac Vet Med, Dept Pathol, Toukh 13736, Egypt.
C3 Princess Nourah bint Abdulrahman University; Egyptian Knowledge Bank
   (EKB); Tanta University; Delta University for Science & Technology;
   Egyptian Knowledge Bank (EKB); Benha University
RP El-Nagar, MMF (corresponding author), Tanta Univ, Fac Pharm, Dept Pharmacol & Toxicol, Tanta 31527, Egypt.
EM maalsonbel@pnu.edu.sa; thanaa.elmasri@pharm.tanta.edu.eg;
   elzahabi@deltauniv.edu.eg; mohamed.gaballah@fvtm.bu.edu.eg;
   maysa_elnagar@outlook.com
RI Gaballa, Mohamed/GXZ-8478-2022; Elmasry, Thanaa/HSH-7601-2023
OI Gaballa, Mohamed/0000-0003-2949-430X
FU Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia
   [PNURSP2024R736]
FX The authors extend their appreciation to Princess Nourah bint
   Abdulrahman University Researchers Supporting Project number
   (PNURSP2024R736), Princess Nourah bint Abdulrahman University, Riyadh,
   Saudi Arabia.
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NR 76
TC 0
Z9 0
U1 1
U2 1
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1999-4923
J9 PHARMACEUTICS
JI Pharmaceutics
PD NOV
PY 2024
VL 16
IS 11
AR 1356
DI 10.3390/pharmaceutics16111356
PG 29
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA N7C5J
UT WOS:001365873900001
PM 39598480
OA gold
DA 2025-06-11
ER

PT J
AU Trojnar, M
   Patro-Malysza, J
   Kimber-Trojnar, Z
   Leszczynska-Gorzelak, B
   Mosiewicz, J
AF Trojnar, Marcin
   Patro-Malysza, Jolanta
   Kimber-Trojnar, Zaneta
   Leszczynska-Gorzelak, Bozena
   Mosiewicz, Jerzy
TI Associations between Fatty Acid-Binding Protein 4-A Proinflammatory
   Adipokine and Insulin Resistance, Gestational and Type 2 Diabetes
   Mellitus
SO CELLS
LA English
DT Review
DE adipose tissue; fatty acid-binding protein 4; proinflammatory adipokine;
   insulin resistance; gestational diabetes mellitus; type 2 diabetes
   mellitus
ID ENDOPLASMIC-RETICULUM STRESS; PPAR-GAMMA; 4 FABP4; LIPID-ACCUMULATION;
   METABOLIC SYNDROME; OXIDATIVE STRESS; LEVELS PREDICT; ADIPOCYTE;
   EXPRESSION; MACROPHAGES
AB There is ample scientific evidence to suggest a link between the fatty acid-binding protein 4 (FABP4) and insulin resistance, gestational (GDM), and type 2 (T2DM) diabetes mellitus. This novel proinflammatory adipokine is engaged in the regulation of lipid metabolism at the cellular level. The molecule takes part in lipid oxidation, the regulation of transcription as well as the synthesis of membranes. An involvement of FABP4 in the pathogenesis of obesity and insulin resistance seems to be mediated via FABP4-dependent peroxisome proliferator-activated receptor gamma (PPAR gamma) inhibition. A considerable number of studies have shown that plasma concentrations of FABP4 is increased in obesity and T2DM, and that circulating FABP4 levels are correlated with certain clinical parameters, such as body mass index, insulin resistance, and dyslipidemia. Since plasma-circulating FABP4 has the potential to modulate the function of several types of cells, it appears to be of extreme interest to try to develop potential therapeutic strategies targeting the pathogenesis of metabolic diseases in this respect. In this manuscript, representing a detailed review of the literature on FABP4 and the abovementioned metabolic disorders, various mechanisms of the interaction of FABP4 with insulin signaling pathways are thoroughly discussed. Clinical aspects of insulin resistance in diabetic patients, including women diagnosed with GDM, are analyzed as well.
C1 [Trojnar, Marcin; Mosiewicz, Jerzy] Med Univ Lublin, Chair & Dept Internal Med, PL-20081 Lublin, Poland.
   [Patro-Malysza, Jolanta; Kimber-Trojnar, Zaneta; Leszczynska-Gorzelak, Bozena] Med Univ Lublin, Chair & Dept Obstet & Perinatol, PL-20090 Lublin, Poland.
C3 Medical University of Lublin; Medical University of Lublin
RP Kimber-Trojnar, Z (corresponding author), Med Univ Lublin, Chair & Dept Obstet & Perinatol, PL-20090 Lublin, Poland.
EM marcin.trojnar@umlub.pl; jolapatro@wp.pl; zkimber@poczta.onet.pl;
   b.leszczynska@umlub.pl; jerzy.mosiewicz@umlub.pl
OI Kimber-Trojnar, Zaneta/0000-0001-7295-0409; Patro-Malysza,
   Jolanta/0000-0002-4118-7698; Mosiewicz, Jerzy/0000-0003-0320-1863;
   Trojnar, Marcin/0000-0001-9318-1995; Leszczynska-Gorzelak,
   Bozena/0000-0002-0221-1982
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NR 99
TC 80
Z9 86
U1 4
U2 19
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2073-4409
J9 CELLS-BASEL
JI Cells
PD MAR 8
PY 2019
VL 8
IS 3
AR 227
DI 10.3390/cells8030227
PG 15
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA HS9MO
UT WOS:000464191600004
PM 30857223
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Ke, K
   Safder, AM
   Sul, OJ
   Suh, JH
   Joe, Y
   Chung, HT
   Choi, HS
AF Ke, Ke
   Safder, Ali Muhammad
   Sul, Ok-Joo
   Suh, Jae-Hee
   Joe, Yeonsoo
   Chung, Hun-Taeg
   Choi, Hye-Seon
TI Cilostazol Attenuates Ovariectomy-Induced Bone Loss by Inhibiting
   Osteoclastogenesis
SO PLOS ONE
LA English
DT Article
ID DIFFERENTIATION; RECEPTOR; MICE; ACTIVATION; CELLS; ATHEROSCLEROSIS;
   SUPPRESSION; SUPEROXIDE; MODULATION; OSTEOBLAST
AB Background
   Cilostazol has been reported to alleviate the metabolic syndrome induced by increased intracellular adenosine 3',5'-cyclic monophosphate (cAMP) levels, which is also associated with osteoclast (OC) differentiation. We hypothesized that bone loss might be attenuated via an action on OC by cilostazol.
   Methodology and Principal Findings
   To test this idea, we investigated the effect of cilostazol on ovariectomy (OVX)-induced bone loss in mice and on OC differentiation in vitro, using mu CT and tartrate-resistant acid phosphatase staining, respectively. Cilostazol prevented from OVX-induced bone loss and decreased oxidative stress in vivo. It also decreased the number and activity of OC in vitro. The effect of cilostazol on reactive oxygen species (ROS) occurred via protein kinase A (PKA) and cAMP-regulated guanine nucleotide exchange factor 1, two major effectors of cAMP. Knockdown of NADPH oxidase using siRNA of p47(phox) attenuated the inhibitory effect of cilostazol on OC formation, suggesting that decreased OC formation by cilostazol was partly due to impaired ROS generation. Cilostazol enhanced phosphorylation of nuclear factor of activated T cells, cytoplasmic 1 (NFAT2) at PKA phosphorylation sites, preventing its nuclear translocation to result in reduced receptor activator of nuclear factor-kappa B ligand-induced NFAT2 expression and decreased binding of nuclear factor-kappa B-DNA, finally leading to reduced levels of two transcription factors required for OC differentiation.
   Conclusions/Significance
   Our data highlight the therapeutic potential of cilostazol for attenuating bone loss and oxidative stress caused by loss of ovarian function.
C1 [Ke, Ke; Safder, Ali Muhammad; Sul, Ok-Joo; Joe, Yeonsoo; Chung, Hun-Taeg; Choi, Hye-Seon] Univ Ulsan, Dept Biol Sci, Ulsan 680749, South Korea.
   [Suh, Jae-Hee] Ulsan Univ Hosp, Dept Pathol, Ulsan 682714, South Korea.
C3 University of Ulsan; University of Ulsan; Ulsan University Hospital
RP Choi, HS (corresponding author), Univ Ulsan, Dept Biol Sci, Ulsan 680749, South Korea.
EM hschoi@mail.ulsan.ac.kr
RI Sul, Onejae/U-9544-2019; Ke, Ke/LYC-1661-2024
OI Ke, Ke/0009-0004-1117-3457; Choi, Hye-Seon/0000-0003-2992-2677; Sul, Ok
   Joo/0000-0002-8517-0898
FU Korea Healthcare Technology R&D Project, Ministry of Health, Welfare &
   Family Affairs, Republic of Korea - Korean government [A111295]; Basic
   Science Research Program through National Research Foundation of Korea
   (NRF) - Ministry of Education [NRF-2014R1A1A2008740, 2014R1A6A1030318]
FX This work was supported by the Korea Healthcare Technology R&D Project,
   Ministry of Health, Welfare & Family Affairs, Republic of Korea
   (A111295) funded by the Korean government. KK (NRF-2014R1A1A2008740),
   AMS, and OJS (2014R1A6A1030318) were supported by Basic Science Research
   Program through the National Research Foundation of Korea (NRF) funded
   by the Ministry of Education. The funders had no role in study design,
   data collection and analysis, decision of publish, or preparation of the
   manuscript.
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NR 39
TC 6
Z9 6
U1 0
U2 0
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAY 18
PY 2015
VL 10
IS 5
AR e0124869
DI 10.1371/journal.pone.0124869
PG 16
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA CI7BG
UT WOS:000354917300011
PM 25992691
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Yang, H
   Nie, YQ
   Li, YY
   Wan, YJY
AF Yang, Hui
   Nie, Yuqiang
   Li, Yuyuan
   Wan, Yu-Jui Yvonne
TI Histone modification-mediated CYP2E1 gene expression and apoptosis of
   HepG2 cells
SO EXPERIMENTAL BIOLOGY AND MEDICINE
LA English
DT Article
DE histone acetylation; CYP2E1; liver cancer; apoptosis; HNF-1; HNF-3 beta
ID ACID INDUCES APOPTOSIS; HEPATOCELLULAR-CARCINOMA; DEACETYLASE
   INHIBITORS; CYTOCHROME-P450 2E1; TRICHOSTATIN-A; OXIDATIVE STRESS;
   HEPATOMA-CELLS; TRANSCRIPTIONAL CONTROL; RAT HEPATOCYTES; UNITED-STATES
AB The incidence of hepatocellular carcinoma is rising due to alcohol drinking, hepatitis C viral infection and metabolic syndrome. Differential expression of CYP2E1 may play a pleiotropic role in the multistep process of liver carcinogenesis. Considerable attention has focused on the antitumor effect of trichostatin A (TSA) as well as CYP2E1 expression-induced apoptosis of cancer cells. However, very few studies have examined the mechanisms by which TSA has an antitumor effect and its association to CYP2E1 expression. The current study examined the action of TSA on CYP2E1 expression and the role of CYP2E1 in inducing apoptosis of HepG2 cells. Our data showed that TSA selectively induced CYP2E1 in four studied human hepatocellular carcinoma (HCC) cell lines (Huh7, PLC/PRF/5, Hep3B and HepG2), but not in normal primary human hepatocytes. TSA-mediated up-regulation of CYP2E1 expression was associated with histone H3 acetylation and the recruitment of HNF-1 and HNF-3 beta to the CYP2E1 promoter in HepG2 cells. siRNA-mediated knockdown experiments showed that TSA-induced caspase-3 cleavage was decreased due to reduced expression of CYP2E1 in HepG2 cells. Moreover, down-regulation of CYP2E1 was accompanied by decreased production of mitochondrial reactive oxygen species. These results suggest that histone modification is involved in CYP2E1 gene expression and that CYP2E1-dependent mitochondrial oxidative stress plays a role in TSA-induced apoptosis.
C1 [Yang, Hui; Nie, Yuqiang; Li, Yuyuan; Wan, Yu-Jui Yvonne] First Municipals People Hosp Guangzhou, Guangzhou Med Coll, Dept Gastroenterol Hepatol, Guangzhou 510180, Guangdong, Peoples R China.
   [Yang, Hui; Wan, Yu-Jui Yvonne] Univ Kansas, Med Ctr, Dept Pharmacol Toxicol & Therapeut, Kansas City, KS 66160 USA.
C3 Guangzhou Medical University; South China University of Technology;
   University of Kansas; University of Kansas Medical Center
RP Wan, YJY (corresponding author), First Municipals People Hosp Guangzhou, Guangzhou Med Coll, Dept Gastroenterol Hepatol, Guangzhou 510180, Guangdong, Peoples R China.
EM ywan@kumc.edu
FU NIH [CA 53596, P20RR021940]
FX We thank Drs Don Warn and Eric Grimes from the Confocal Core at the
   University of Kansas Medical Center for technical assistance with the
   confocal microscope. We thank Barbara Brede for proofreading this
   manuscript. This work was supported by NIH grants CA 53596 and
   P20RR021940 Molecular Biology Core.
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NR 59
TC 35
Z9 37
U1 0
U2 9
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1535-3702
EI 1535-3699
J9 EXP BIOL MED
JI Exp. Biol. Med.
PD JAN
PY 2010
VL 235
IS 1
BP 32
EP 39
DI 10.1258/ebm.2009.009252
PG 8
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 555TK
UT WOS:000274538200006
PM 20404016
OA Green Accepted
DA 2025-06-11
ER

PT J
AU ter Avest, E
   Abbink, EJ
   de Graaf, J
   Tack, CJ
   Stalenhoef, AFH
AF ter Avest, E
   Abbink, EJ
   de Graaf, J
   Tack, CJ
   Stalenhoef, AFH
TI Effect of rosuvastatin on insulin sensitivity in patients with familial
   combined hyperlipidaemia
SO EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
LA English
DT Article
DE familial combined hyperlipidaemia; insulin sensitivity; rosuvastatin
ID LOW-DENSITY-LIPOPROTEIN; C-REACTIVE PROTEIN; DEPENDENT
   DIABETES-MELLITUS; METABOLIC SYNDROME; RESISTANCE ATHEROSCLEROSIS;
   ADIPOSE-TISSUE; DOUBLE-BLIND; FATTY-ACIDS; SIMVASTATIN; PRAVASTATIN
AB Background By influencing the mevalonate pathway, statins may have multiple effects besides lipid lowering. This study was designed to evaluate the effect of rosuvastatin on serum lipids and insulin sensitivity in nondiabetic subjects with familial combined hyperlipidaemia (FCH), a population characterized by decreased insulin sensitivity.
   Methods In a double-blind randomized crossover study, 18 subjects with FCH (without evident cardiovascular disease, mean age 54 +/- 7 years) were randomized to rosuvastatin 40 mg day(-1) or placebo for 12 weeks. Blood samples were taken at baseline and after 4, 8 and 12 weeks of both treatment periods. Insulin sensitivity was determined with euglycaemic-hyperinsulinaemic clamp after 12 weeks of both treatment periods.
   Results Serum lipids and lipoproteins improved significantly. Mean total cholesterol after the rosuvastatin treatment period was 44% lower compared to the placebo treatment period (triglycerides -28%; LDL-c -50%; VLDL-c -56%, VLDL-TG -39%) and both parameters of low-grade inflammation (as measured by hsCRP, -16%) and oxidative stress (as measured by plasma-oxLDL, -55%) decreased markedly after rosuvastatin therapy as compared to placebo. However, the insulin sensitivity index was unchanged (41.7 +/- 17.4 vs. 40.6 +/- 11.1 L kg(-1) min(-1), placebo vs. rosuvastatin, P = 0.71).
   Conclusion Despite marked improvements in lipid and lipoprotein values, low-grade inflammation and oxidative stress, a relatively high dose of rosuvastatin did not change insulin sensitivity in subjects with FCH.
C1 Radboud Univ Nijmegen Med Ctr, Dept Med, Div Gen Internal Med, Nijmegen, Netherlands.
C3 Radboud University Nijmegen
RP Radboud Univ Nijmegen Med Ctr, Div Gen Internal Med 541, POB 9101, NL-6500 HB Nijmegen, Netherlands.
EM a.stalenhoef@aig.umcn.nl
RI Stalenhoef, A.F.H./H-8094-2014; Tack, Cees/A-2368-2014; de Graaf,
   J./H-8038-2014
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NR 39
TC 34
Z9 34
U1 0
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0014-2972
EI 1365-2362
J9 EUR J CLIN INVEST
JI Eur. J. Clin. Invest.
PD SEP
PY 2005
VL 35
IS 9
BP 558
EP 564
DI 10.1111/j.1365-2362.2005.01549.x
PG 7
WC Medicine, General & Internal; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Research & Experimental Medicine
GA 959GR
UT WOS:000231506700004
PM 16128862
DA 2025-06-11
ER

PT J
AU Giacco, R
   Costabile, G
   Fatati, G
   Frittitta, L
   Maiorino, MI
   Marelli, G
   Parillo, M
   Pistis, D
   Tubili, C
   Vetrani, C
   Vitale, M
AF Giacco, Rosalba
   Costabile, Giuseppina
   Fatati, Giuseppe
   Frittitta, Lucia
   Maiorino, Maria, I
   Marelli, Giuseppe
   Parillo, Mario
   Pistis, Danila
   Tubili, Claudio
   Vetrani, Claudia
   Vitale, Marilena
TI Effects of polyphenols on cardio-metabolic risk factors and risk of type
   2 diabetes. A joint position statement of the Diabetes and Nutrition
   Study Group of the Italian Society of Diabetology (SID), the Italian
   Association of Dietetics and Clinical Nutrition (ADI) and the Italian
   Association of Medical Diabetologists (AMD)
SO NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
LA English
DT Article
DE Dietary polyphenols; Cardiovascular risk factors; Type 2 diabetes
ID GRAPE SEED EXTRACT; IMPROVE INSULIN SENSITIVITY; LOW-GRADE INFLAMMATION;
   GREEN TEA CONSUMPTION; BLOOD-PRESSURE; DOUBLE-BLIND; CARDIOVASCULAR
   RISK; DIETARY POLYPHENOLS; COFFEE CONSUMPTION; OXIDATIVE STRESS
AB Aim: A large body of evidence supports a role of polyphenols in the prevention of chronic diseases, i.e. type 2 diabetes (DMT2), cardiovascular diseases and some types of cancer. In the present manuscript, the effect of polyphenol/phenolic compounds on the main cardio-metabolic risk factors (body weight, blood pressure, blood glucose concentrations, plasma lipids, inflammation and oxidative stress) in humans will be discussed.
   Data synthesis: Epidemiological evidence supports the beneficial effects of polyphenol-rich diets in the prevention of T2D risk. However, the available evidence from randomized controlled clinical trials did not allow the identification of specific phenolic compounds or polyphenol-rich foods that effectively improve cardio-metabolic risk factors. The most promising results in terms of the management of cardio-metabolic risk factors derive from RCTs based on a long-term intake of polyphenol-rich foods and beverages. Therefore, future studies should focus on a diet containing different classes of polyphenols rather than a specific food or phenolic compound. The hypothesis is that a polyphenol-rich diet may have a pleiotropic effect on cardiometabolic risk factors thanks to the specific action of different polyphenol subclasses.
   Conclusion: The lack of conclusive evidence on the effectiveness of polyphenols in the management of cardio-metabolic risk factors does not allow recommendation of their use as supplements to reduce T2D and CVD risk. However, the daily consumption of naturally polyphenol- rich foods and beverages might be advised according to the current nutritional dietary recommendation. (C) 2019 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.
C1 [Giacco, Rosalba] CNR, Inst Food Sci, Avellino, Italy.
   [Giacco, Rosalba; Costabile, Giuseppina; Frittitta, Lucia; Maiorino, Maria, I; Vetrani, Claudia; Vitale, Marilena] Italian Soc Diabetol SID, Rome, Italy.
   [Costabile, Giuseppina; Vetrani, Claudia; Vitale, Marilena] Univ Naples Federico II, Dept Clin Med & Surg, Via Pansini 5, I-80131 Naples, Italy.
   [Fatati, Giuseppe] S Maria Hosp, Unit Diabetol Dietol & Clin Nutr, Terni, Italy.
   [Fatati, Giuseppe; Parillo, Mario; Tubili, Claudio] Italian Assoc Dietet & Clin Nutr ADI, Rome, Italy.
   [Frittitta, Lucia] Univ Catania, Garibaldi Hosp, Dept Clin & Expt Med, Endocrinol, Via Palermo 636, I-95122 Catania, Italy.
   [Maiorino, Maria, I] Univ Campania Luigi Vanvitelli, Dept Adv Med & Surg Sci, Diabet Unit, Naples, Italy.
   [Marelli, Giuseppe] Vimercate Hosp, Unit Endocrinol Diabetol & Clin Nutr, Vimercate, Italy.
   [Marelli, Giuseppe; Pistis, Danila] AMD, Rome, Italy.
   [Parillo, Mario] St Anna & St Sebastian Hosp, Dept Internal Med, Caserta, Italy.
   [Pistis, Danila] ATS Sardegna UO Diabetol Poliambulatorio Quartu S, Cagliari, Italy.
   [Tubili, Claudio] S Camillo Forlanini Hosp, Diabet Unit, Rome, Italy.
C3 Consiglio Nazionale delle Ricerche (CNR); Istituto di Scienze dell'
   Alimentazione (ISA-CNR); University of Naples Federico II; University of
   Catania; Universita della Campania Vanvitelli; Ospedale di Vimercate;
   Azienda Ospedaliera San Camillo-Forlanini
RP Costabile, G (corresponding author), Univ Naples Federico II, Dept Clin Med & Surg, Via Pansini 5, I-80131 Naples, Italy.
EM giuseppina.costabile@unina.it
RI Costabile, Giuseppina/AAJ-8382-2020; Maiorino, Maria Ida/AHE-9986-2022;
   frittitta, lucia/J-2334-2012; Maiorino, Maria Ida/K-3264-2016; Vetrani,
   Claudia/D-3306-2018; Vitale, Marilena/J-1457-2014
OI Maiorino, Maria Ida/0000-0003-4659-7546; Vetrani,
   Claudia/0000-0001-8335-5939; Costabile, Giuseppina/0000-0001-5761-8002;
   Vitale, Marilena/0000-0001-9951-4674
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NR 136
TC 32
Z9 32
U1 1
U2 31
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0939-4753
EI 1590-3729
J9 NUTR METAB CARDIOVAS
JI Nutr. Metab. Carbiovasc. Dis.
PD MAR 9
PY 2020
VL 30
IS 3
BP 355
EP 367
DI 10.1016/j.numecd.2019.11.015
PG 13
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism; Nutrition
   & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism;
   Nutrition & Dietetics
GA KQ2HK
UT WOS:000516749500001
PM 31918979
DA 2025-06-11
ER

PT J
AU Wang, NN
   Ma, YN
   Liu, ZQ
   Liu, L
   Yang, KM
   Wei, YG
   Liu, Y
   Chen, X
   Sun, XC
   Wen, DL
AF Wang, Ningning
   Ma, Yanan
   Liu, Zhuoqun
   Liu, Lei
   Yang, Keming
   Wei, Yaguang
   Liu, Yang
   Chen, Xin
   Sun, Xiance
   Wen, Deliang
TI Hydroxytyrosol prevents PM2.5-induced adiposity and insulin
   resistance by restraining oxidative stress related NF-κB pathway and
   modulation of gut microbiota in a murine model
SO FREE RADICAL BIOLOGY AND MEDICINE
LA English
DT Article
DE Fine particular matter; PM2.5; Hydroxytyrosol; Oxidative stress; Gut
   microbiota; Insulin resistance; Adiposity
ID AMBIENT AIR-POLLUTION; ENDOPLASMIC-RETICULUM STRESS; INDUCED METABOLIC
   SYNDROME; STAPHYLOCOCCUS-AUREUS; RAT MODEL; IKK-BETA; OBESITY;
   INFLAMMATION; EXPOSURE; DIET
AB Exposure to fine particular matter (<= 2.5 mu M, PM2.5) contributes to increased risk of obesity and type 2 diabetes. Hydroxytyrosol (HT), a simple polyphenol found in virgin olive oil, is considered to be beneficial for cardiovascular and metabolic disorders. The current study determined whether HT could improve PM2.5-induced adiposity and insulin resistance (IR), and explored the underlying mechanisms. Fifteen adult female C57BL/6j mice on a chow diet were randomly divided into three groups receiving (1) sterile PBS, (2) PM2.5 suspended in sterile PBS (1 mg/mL) and (3) PM2.5 + HT (50 mg/kg/day). PM2.5/PBS exposure was administered by oropharynx instillation every other day and HT supplementation was achieved by gavage every day. Four-week PM2.5 exposure did not affect body weight, but significantly increased visceral fat mass. The abdominal adiposity coincided with adipocyte hypertrophy and proliferation in visceral white adipose tissue (WAT), as well as decreased metabolic activity in brown adipose tissue and subcutaneous WAT. PM2.5 enhanced the oxidative stress by diminishing antioxidant enzyme activities in liver and serum, whereas contents of 4-hydroxynonenal (4-HNE), malondialdehyde (MDA) levels in liver and serum were elevated. These changes were accompanied by macrophage infiltration and activation of NF-kappa B pathway in the liver. Moreover, PM2.5 exposure led to glucose intolerance and insulin insensitivity, impaired hepatic glycogenesis, and decreased insulin-stimulated Akt phosphorylation in peripheral tissues. Importantly, HT treatment prevented PM2.5-induced visceral adipogenesis, oxidative stress, hepatic inflammation and NF-kappa B activation, systemic and peripheral IR. In vitro, after HepG2 cells were incubated with PM2.5 (0, 5, 25, 50, 100 and 200 pg/mL), reduced glutathione depletion and 4-HNE, 8-hydroxy-2'-deoxyguanosine, MDA increment in a dose-dependent manner were observed; likewise, insulin-stimulated glucose uptake decreased in a dose-dependent manner. Further, with antioxidant NAC and NF-kappa B inhibitor PDTC, we confirmed that HT attenuated PM2.5-induced IR through restraining NF-kappa B activation evoked by oxidative stress. In addition, HT could expand gut microbiota richness, reduce pathogenic bacteria and accommodate the microbial architecture in PM2.5-exposed mice, which were correlated with parameters of adiposity, oxidative stress and glycometabolism. HT could effectively correct imbalanced oxidative stress triggered by PM2.5, in turn ameliorated NF-kappa B pathway and insulin signaling. Gut microbiota may mediate the actions of HT.
C1 [Wang, Ningning] Dalian Med Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Dalian, Liaoning, Peoples R China.
   [Ma, Yanan] China Med Univ, Sch Publ Hlth, Shenyang, Liaoning, Peoples R China.
   [Liu, Zhuoqun; Liu, Lei] Dalian Med Univ, Sch Publ Hlth, Dalian, Liaoning, Peoples R China.
   [Yang, Keming] Indiana Univ, Richard M Fairbanks Sch Publ Hlth, Dept Epidemiol, Indianapolis, IN 46204 USA.
   [Wei, Yaguang] Harvard TH Chan Sch Publ Hlth, Dept Environm Hlth, Boston, MA USA.
   [Liu, Yang; Wen, Deliang] China Med Univ, Inst Hlth Sci, 77 Puhe Rd, Shenyang, Liaoning, Peoples R China.
   [Chen, Xin] Dalian Med Univ, Sch Publ Hlth, Dept Epidemiol, Dalian, Liaoning, Peoples R China.
   [Sun, Xiance] Dalian Med Univ, Sch Publ Hlth, Dept Occupat & Environm Hlth, Dalian, Liaoning, Peoples R China.
C3 Dalian Medical University; China Medical University; Dalian Medical
   University; Indiana University System; Indiana University Indianapolis;
   Harvard University; Harvard T.H. Chan School of Public Health; China
   Medical University; Dalian Medical University; Dalian Medical University
RP Wen, DL (corresponding author), China Med Univ, Inst Hlth Sci, 77 Puhe Rd, Shenyang, Liaoning, Peoples R China.
EM zkxwnn@dmu.edu.cn; ynma@cmu.edu.cn; 978337926@qq.com;
   liulei_dmu@163.com; kemyang@iu.edu; weiyg@g.harvard.edu;
   cmu_ly@hotmail.com; chenx@dmu.edu.cn; sunxiance@aliyun.com;
   dlwen@cmu.edu.cn
RI Wang, Ningning/KCX-7219-2024; Wei, Yaguang/AFN-8388-2022
OI liu, zhuoqun/0009-0008-2904-1590
FU National Natural Science Foundation of China [71774173]; Liaoning
   Provincial Natural Science Foundation of China [20180530054]
FX This work was supported by National Natural Science Foundation of China
   (71774173), and Liaoning Provincial Natural Science Foundation of China
   (20180530054).
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NR 68
TC 64
Z9 68
U1 7
U2 98
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0891-5849
EI 1873-4596
J9 FREE RADICAL BIO MED
JI Free Radic. Biol. Med.
PD SEP
PY 2019
VL 141
BP 393
EP 407
DI 10.1016/j.freeradbiomed.2019.07.002
PG 15
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA IU9SG
UT WOS:000483920100035
PM 31279968
DA 2025-06-11
ER

PT J
AU Hu, YQ
   Zhao, HR
   Lu, JM
   Xie, D
   Wang, Q
   Huang, TL
   Xin, HC
   Hisatome, I
   Yamamoto, T
   Wang, W
   Cheng, JD
AF Hu, Yaqiu
   Zhao, Hairong
   Lu, Jiaming
   Xie, De
   Wang, Qiang
   Huang, Tianliang
   Xin, Hancheng
   Hisatome, Ichiro
   Yamamoto, Tetsuya
   Wang, Wei
   Cheng, Jidong
TI High uric acid promotes dysfunction in pancreatic β cells by blocking
   IRS2/AKT signalling
SO MOLECULAR AND CELLULAR ENDOCRINOLOGY
LA English
DT Article
DE High uric acid; Pancreatic beta-cell; Insulin resistance; Oxidative
   stress; Glycolysis
ID METABOLIC SYNDROME; MITOCHONDRIAL-FUNCTION; INSULIN-RESISTANCE;
   OXIDATIVE STRESS; GLUCOSE; SECRETION; ASSOCIATION; MELLITUS; PATHWAYS;
   LINE
AB Hyperuricaemia is a disorder of purine metabolism. Elevated serum uric acid is strongly associated with many diseases, including gout, abdominal obesity, insulin resistance, and cardiovascular and kidney disease. Our previous studies showed that high uric acid (HUA) induced insulin resistance in several peripheral organs, including the liver, myocardium and adipose tissue. However, whether HUA directly induces insulin resistance of pancreatic beta cells, the only source of insulin in the body and also a sensitive insulin target, is unknown. In this study, pancreatic beta cells pretreated with HUA showed impaired insulin expression/secretion, glucose uptake and the glycolytic pathway. RNA-seq revealed that HUA affected the biological processes of INS-1 cells broadly, including oxidoreduction coenzyme metabolic process, pyruvate metabolic process, and glycolytic process. In addition, HUA reduced mitochondrial membrane potential and increased the production of reactive oxygen species(ROS) in INS-1 cells. INS-1 cells pretreated with pmbenecid, an organic anion transporter inhibitor, protected INS-1 cells against HUA-induced insulin secretion decrease, Pretreatment with N-acetyl-L-cysteine (NAC), a globally used antioxidant, recovered HUA-decreased insulin secretion and glucose uptake by pancreatic beta cells. Insulin-like growth factor 1 (IGF-1), the phosphatidylinositol beta-kinase (PI3K) activator, rescues HUA-decreased insulin secretion by re-activating AKT phosphorylation. Thus, HUA induce insulin resistance, impaired insulin secretion and glycolytic pathway of pancreatic beta cell through IRS2/AKT pathway.
C1 [Zhao, Hairong; Lu, Jiaming; Xie, De; Wang, Qiang; Wang, Wei; Cheng, Jidong] Xiamen Univ, Dept Endocrinol, Xiangan Hosp, Xiamen, Fujian, Peoples R China.
   [Hu, Yaqiu; Huang, Tianliang; Xin, Hancheng] Shantou Univ Med Coll, Affiliated Hosp 1, Dept Internal Med, Shantou, Guangdong, Peoples R China.
   [Hisatome, Ichiro] Tottori Univ, Grad Sch Med Sci, Inst Regenerat Med & Biofunct, Div Regenerat Med & Therapeut, Yonago, Tottori, Japan.
   [Yamamoto, Tetsuya] Hyogo Coll Med, Dept Internal Med, Nishinomiya, Hyogo, Japan.
C3 Xiamen University; Shantou University; Tottori University; Hyogo Medical
   University
RP Wang, W; Cheng, JD (corresponding author), Xiamen Univ, Dept Endocrinol, Xiangan Hosp, Xiamen, Fujian, Peoples R China.
EM wwei19742007@hotmail.com; jidongcheng36@hotmail.com
RI lu, jm/JPK-3675-2023; zhao, hairong/KVC-0567-2024
OI Zhao, Hairong/0000-0003-0000-8136
FU National Natural Science Foundation of China [81703742, 81570772,
   81471081]; Natural Science Foundation of Guangdong Province
   [2015A030313434]; Natural Science Foundation of Fujian Province
   [2019J01010]; Gout Research Foundation (Japan)
FX This work was supported by grants from the National Natural Science
   Foundation of China (81703742, 81570772 and 81471081), the Natural
   Science Foundation of Guangdong Province (2015A030313434), the Natural
   Science Foundation of Fujian Province (2019J01010) and the Gout Research
   Foundation (Japan,2019). The experiments were mainly carried out in the
   Center Laboratory, First Affiliated Hospital, Shantou University Medical
   College. The authors would like to thank Core Facility of Biomedical,
   Xiamen University for assistance with fluorescenceactivated cell sorting
   (Beckmen, MoFlo Astrios EQS) confocal microscopy (FV1000MPE-B, Olympus).
   The authors would like to also thank Xiang You, Jing Ru Huang and
   Haiping Zheng.
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U1 1
U2 32
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0303-7207
EI 1872-8057
J9 MOL CELL ENDOCRINOL
JI Mol. Cell. Endocrinol.
PD JAN 15
PY 2021
VL 520
AR 111070
DI 10.1016/j.mce.2020.111070
PG 11
WC Cell Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Endocrinology & Metabolism
GA PH9XV
UT WOS:000600756700004
PM 33127482
DA 2025-06-11
ER

PT J
AU Kim, HS
   Park, JA
   Na, JS
   Lee, KH
   Bae, KH
AF Kim, Hyang-Sun
   Park, Ji-A
   Na, Jun-Sung
   Lee, Kyoung-Hoon
   Bae, Kwang-Hak
TI Association Between Plasma Levels of Manganese and Periodontal Status: A
   Study Based on the Fourth Korean National Health and Nutrition
   Examination Survey
SO JOURNAL OF PERIODONTOLOGY
LA English
DT Article
DE Antioxidants; inflammation; manganese; nutrition surveys; periodontal
   diseases; oxidative stress
ID SUPEROXIDE-DISMUTASE ACTIVITY; OXIDATIVE STRESS; METABOLIC SYNDROME;
   GLUTATHIONE-PEROXIDASE; ANTIOXIDANT ENZYMES; SMOKING-CESSATION; REACTIVE
   OXYGEN; MENSTRUAL-CYCLE; DISEASE; INFLAMMATION
AB Background: This study aims to evaluate the association between plasma levels of manganese (Mn) and periodontal status in a representative sample of Korean adults.
   Methods: Plasma levels of Mn and periodontal status were analyzed in 1,679 participants, all of whom were >19 years old. Plasma levels of Mn were divided into four quartiles: first (<1.057 mu g/dL), second (1.057 to 1.274 mu g/dL), third (1.275 to 1.544 mu g/dL), and fourth (>1.544 mu g/dL). Periodontal status was assessed using the Community Periodontal Index (CPI). Multivariate logistic regression analyses were performed after adjusting for sociodemographic variables, oral and general health behavior, oral health status, and systemic conditions. All analyses took into consideration the complex sampling design, and multivariate analyses were performed in the subgroups.
   Results: Multivariate logistic regression analyses revealed a significant association between plasma levels of Mn and higher CPI in the total sample. There was a moderate association between first-quartile plasma levels of Mn and higher CPI in males (odds ratio [OR]: 2.13; 95% confidence interval [CI] 1.25 to 3.63) and current smokers (OR: 2.07; 95% CI 1.04 to 4.11), compared to the fourth quartile.
   Conclusion: Periodontal status is significantly associated with plasma levels of Mn in Korean adults, especially in men and smokers.
C1 [Kim, Hyang-Sun] Seoul Natl Univ, Coll Med, Dept Physiol, Seoul 110749, South Korea.
   [Park, Ji-A; Bae, Kwang-Hak] Seoul Natl Univ, Sch Dent, Dept Prevent & Publ Hlth Dent, Seoul 110749, South Korea.
   [Na, Jun-Sung] Korean Minjok Leadership Acad, Hoengseong Gun, Gangwon Do, South Korea.
   [Lee, Kyoung-Hoon] Daejeonjungang High Sch, Taejon, South Korea.
   [Bae, Kwang-Hak] Seoul Natl Univ, Sch Dent, Dent Res Inst, Seoul 110749, South Korea.
C3 Seoul National University (SNU); Seoul National University (SNU); Seoul
   National University (SNU)
RP Bae, KH (corresponding author), Seoul Natl Univ, Sch Dent, Dept Prevent & Publ Hlth Dent, 28 Yeongeuon Dong, Seoul 110749, South Korea.
EM baekh@snu.ac.kr
OI PARK, JI-A/0000-0002-7397-5701
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NR 47
TC 5
Z9 6
U1 0
U2 4
PU AMER ACAD PERIODONTOLOGY
PI CHICAGO
PA 737 NORTH MICHIGAN AVENUE, SUITE 800, CHICAGO, IL 60611-2690 USA
SN 0022-3492
EI 1943-3670
J9 J PERIODONTOL
JI J. Periodont.
PD DEC
PY 2014
VL 85
IS 12
BP 1748
EP 1754
DI 10.1902/jop.2014.140250
PG 7
WC Dentistry, Oral Surgery & Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dentistry, Oral Surgery & Medicine
GA AU6XI
UT WOS:000345744300015
PM 25079397
DA 2025-06-11
ER

PT J
AU Wallerius, S
   Rosmond, R
   Ljung, T
   Holm, G
   Björntorp, P
AF Wallerius, S
   Rosmond, R
   Ljung, T
   Holm, G
   Björntorp, P
TI Rise in morning saliva cortisol is associated with abdominal obesity in
   men:: A preliminary report
SO JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
LA English
DT Article
DE saliva cortisol; awakening; risk factors; men
ID SECRETION; STRESS
AB An abnormal regulation of the hypothalamic-pituitary-adrenal (HPA) axis is associated with risk factors for cardiovascular disease and Type 2 diabetes mellitus. The objective of this study was to examine if morning saliva cortisols show similar associations. Twenty-eight men, all 53 yr of age, delivered during an ordinary working day saliva cortisol samples immediately upon awakening and 15 min thereafter as well as at different times during the day, including after a standardized lunch. Dexamethasone (0.5 mg) suppression of cortisol was also measured. The rise of morning cortisol values was positively associated with body mass index (r: 0.45, p=0.016), waist/hip ratio (r: 0.54, p=0.003), abdominal sagittal diameter (r: 0.54, p=0.003), glucose (r: 0.54, p=0.003), insulin (r: 0.57, p=0.002) and triglycerides (r: 0.46, p=0.014). The morning rise also correlated positively with the elevation of cortisol following lunch (r: 0.45, p=0.043) but not with other cortisol measurements or dexamethasone suppression. Elevation of cortisol immediately after awakening has previously been found to provide a simple indicator of HPA axis regulation, as suggested also by the results of this study, and an elevated rise has been reported after exposure to frequent or chronic perceived stress. The rise of cortisol immediately after awakening might be an indicator of an increased risk of developing serious, prevalent diseases via the metabolic syndrome. (C) 2003, Editrice Kurtis.
C1 Univ Gothenburg, Dept Heart & Lung Dis, S-41345 Gothenburg, Sweden.
C3 University of Gothenburg
RP Björntorp, P (corresponding author), Univ Gothenburg, Dept Heart & Lung Dis, S-41345 Gothenburg, Sweden.
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NR 13
TC 96
Z9 118
U1 0
U2 4
PU EDITRICE KURTIS S R L
PI MILAN
PA VIA LUIGI ZOJA 30, 20153 MILAN, ITALY
SN 0391-4097
J9 J ENDOCRINOL INVEST
JI J. Endocrinol. Invest.
PD JUL
PY 2003
VL 26
IS 7
BP 616
EP 619
DI 10.1007/BF03347017
PG 4
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 729PA
UT WOS:000185781300004
PM 14594110
DA 2025-06-11
ER

PT J
AU Sarikaya, B
   Kolay, E
   Guney-Coskun, M
   Ziolkowski, AY
   Aktaç, S
AF Sarikaya, Buse
   Kolay, Ezgi
   Guney-Coskun, Merve
   Yigit- Ziolkowski, Asli
   Aktac, Sule
TI The Effect of Black Chokeberry (Aronia melanocarpa) on Human
   Inflammation Biomarkers and Antioxidant Enzymes: A Systematic Review of
   Randomized Controlled Trials
SO NUTRITION REVIEWS
LA English
DT Review
DE antioxidants; Aronia melanocarpa; black chokeberry; inflammation
ID LOW-GRADE INFLAMMATION; NF-KAPPA-B; OXIDATIVE STRESS; BLOOD-PRESSURE;
   DOUBLE-BLIND; JUICE SUPPLEMENTATION; CARDIOMETABOLIC RISK; LIPID STATUS;
   CONSUMPTION; EXTRACT
AB Context: Consuming antioxidant-rich foods has been associated with potential benefits in managing chronic diseases by reducing oxidative stress and inflammation. Objective: This systematic review aimed to evaluate the effects of Aronia melanocarpa (aronia berry or chokeberry) on human inflammation biomarkers and antioxidant enzymes. Data Sources: A systematic search was conducted across multiple databases, including PubMed, Scopus, Science Direct, and Web of Science, to identify relevant studies investigating the potential effects of aronia on human inflammation biomarkers and antioxidant enzymes between April 2022 and November 2023. Data Extraction: The selection of studies followed the PRISMA guidelines, data screening was conducted by 4 independent reviewers, and data extraction and risk-of-bias assessments were performed by 2 independent reviewers using the Cochrane Risk of Bias 2 tool. Data Analysis: A total of 1986 studies were screened, and 18 studies that met the inclusion criteria were included in a systematic review that investigated the anti-inflammatory effects of aronia on various health parameters. These studies primarily focused on the effects of aronia on cardiometabolic diseases, performance in sport, and other health parameters. Conclusions: This study exam: ined the effects of Aronia intervention on human health outcomes using aronia juice, extract, or oven-dried powder for a period of 4 to 13 weeks. The primary health parameters considered were C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-alpha), interleukin-8 (IL-8), interleukin-10 (IL-10), interleukin-1 ss (IL-1 ss), superoxide dismutase (SOD), catalase (CAT), and reduced glutathione peroxidase (GSH-Px). The results showed that aronia had a beneficial effect on several inflammatory cytokines, including reductions in CRP, TNF-alpha and IL-6 concentrations, as well as elevated IL-10 levels. Moreover, positive changes have been observed in antioxidant enzyme systems, including; elevated SOD, GSH-Px and CAT activity. The findings of the presented studies provide evidence that Aronia melanocarpa may have beneficial effects on inflammatory markers. Systematic Review Registration: PROSPERO registration No. CRD42022325633.
C1 [Sarikaya, Buse] Amasya Univ, Dept Nutr & Dietet, Fac Hlth Sci, TR-05100 Amasya, Turkiye.
   [Guney-Coskun, Merve] Medipol Univ, Fac Hlth Sci, Dept Nutr & Dietet, TR-34810 Istanbul, Turkiye.
   [Yigit- Ziolkowski, Asli] Poznan Univ Life Sci, Dept Biochem & Biotechnol, PL-60632 Poznan, Poland.
   [Aktac, Sule] Marmara Univ, Fac Hlth Sci, Dept Nutr & Dietet, TR-34854 Istanbul, Turkiye.
C3 Amasya University; Istanbul Medipol University; Poznan University of
   Life Sciences; Marmara University
RP Sarikaya, B (corresponding author), Amasya Univ, Fac Hlth Sci, Dept Nutr & Dietet, TR-05100 Merkez Amasya, Turkiye.
EM buse.sarikaya@amasya.edu.tr
RI Kolay, Ezgi/AFQ-9261-2022; Guney-Coskun, Merve/CAF-6140-2022; Yiğit,
   Aslı/HJH-3344-2023; AKTAÇ, ŞULE/AAD-3809-2019
OI Guney Coskun, Merve/0000-0002-5940-2413; Kolay,
   Ezgi/0000-0001-7040-819X; Sarikaya, Buse/0000-0001-8555-6662; Yigit
   Ziolkowski, Asli/0000-0001-5919-2244
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NR 108
TC 2
Z9 2
U1 7
U2 11
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0029-6643
EI 1753-4887
J9 NUTR REV
JI Nutr. Rev.
PD JUN
PY 2025
VL 83
IS 6
BP 1083
EP 1098
DI 10.1093/nutrit/nuae143
EA NOV 2024
PG 16
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 2KZ2V
UT WOS:001348049300001
PM 39499790
DA 2025-06-11
ER

PT J
AU Vega-Cárdenas, M
   Vargas-Morales, JM
   Portales-Pérez, DP
   Gómez-Ojeda, A
   Luevano-Contreras, C
   Aradillas-García, C
AF Vega-Cardenas, Mariela
   Vargas-Morales, Juan Manuel
   Portales-Perez, Diana Patricia
   Gomez-Ojeda, Armando
   Luevano-Contreras, Claudia
   Aradillas-Garcia, Celia
TI Soluble receptor for advanced glycation end-products (sRAGE) in
   childhood obesity: association with gene expression of RAGE and
   cardiometabolic markers
SO NUTRICION HOSPITALARIA
LA English
DT Article
DE sRAGE; Cardiometabolic markers; RAGE; Childhood obesity
ID CHILDREN; ISOFORMS; STRESS; HEALTH; RISK
AB Introduction: advanced glycation end-products (AGEs) interact with the receptor for AGEs (RAGE). Full-length RAGE is associated with intracellular signal transduction, and soluble-RAGE (sRAGE) lacks the transmembrane and cytoplasmic domains, acting as a competitive inhibitor of AGEs-RAGE binding. sRAGE levels in healthy children are associated with cell surface expression of RAGE. However, the expression of RAGE has not been explored in childhood obesity.Objective: the study aim was to evaluate the sRAGE levels and the gene expression of RAGE in children and its association with cardiometabolic markers.Methods: this is a cross-sectional study with 6-11-year children, 20 with overweight and 20 with obesity. Anthropometric measurements included waist circumference (cm) (WC), neck circumference (NC), weight (kg), fat mass (%), trunk fat (kg), muscular mass (kg), height (cm), and body mass index (BMI) (kg/m(2)). Blood samples following an overnight fast were collected to measure glucose (mg/dl) and lipid profile with colorimetric methods. sRAGE was determined in serum using the enzyme-linked immunosorbent assay (ELISA). Quantitative reverse transcription (RT-qPCR) was performed to analyze RAGE transcripts in peripheral blood mononuclear cells isolated by Ficoll (R)-Hypaque.Results: we found higher RAGE (p = 0.0315) and lower sRAGE (p = 0.0305) levels in the obesity group. sRAGE level showed a negative correlation with RAGE (r =-0.35) and BMI (r =-0.24), and positive with HDL-cholesterol (r = 0.29). Regression analysis suggests that HDL-C and RAGE levels are predictors of sRAGE levels.Conclusions: expression of RAGE is associated with lower sRAGE levels in childhood obesity. Moreover, obese children show higher cardiometabolic risk markers, and a positively associated with sRAGE.
C1 [Vega-Cardenas, Mariela] Ctr Appl Res Environm & Hlth CIACYT, San Luis Potosi, Mexico.
   [Vargas-Morales, Juan Manuel; Portales-Perez, Diana Patricia] Univ Autonoma San Luis Potosi, Fac Chem Sci, San Luis Potosi, Mexico.
   [Gomez-Ojeda, Armando; Luevano-Contreras, Claudia] Univ Guanajuato, Dept Med Sci, Leon, Mexico.
   [Aradillas-Garcia, Celia] Univ Autonoma San Luis Potosi, Fac Med, San Luis Potosi, Mexico.
   [Aradillas-Garcia, Celia] Univ Autonoma San Luis Potosi, Fac Med, Dept Publ Hlth, Av Venustiano Carranza,2405 Colonia Filtros, San Luis Potosi 78210, Mexico.
C3 Universidad Autonoma de San Luis Potosi; Universidad de Guanajuato;
   Universidad Autonoma de San Luis Potosi; Universidad Autonoma de San
   Luis Potosi
RP Aradillas-García, C (corresponding author), Univ Autonoma San Luis Potosi, Fac Med, Dept Publ Hlth, Av Venustiano Carranza,2405 Colonia Filtros, San Luis Potosi 78210, Mexico.
RI Luevano-Contreras, Claudia/ADJ-1806-2022; Garcia, Celia/B-5830-2014
OI GOMEZ-OJEDA, ARMANDO/0009-0005-3711-8605; Luevano-Contreras,
   Claudia/0000-0002-2632-8093
CR González-Cortés CA, 2019, MEDICINA-LITHUANIA, V55, DOI 10.3390/medicina55050183
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NR 35
TC 5
Z9 5
U1 0
U2 1
PU ARAN EDICIONES, S L
PI MADRID
PA C/ CASTELLO, 128, 1O, MADRID, 28006, SPAIN
SN 0212-1611
EI 1699-5198
J9 NUTR HOSP
JI Nutr. Hosp.
PD SEP-OCT
PY 2023
VL 40
IS 5
BP 960
EP 966
DI 10.20960/nh.04666
PG 7
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA Z5MG2
UT WOS:001112508400001
PM 37732356
OA gold
DA 2025-06-11
ER

PT J
AU Hirschler, V
   Martin, M
   Molinari, C
   Botta, E
   Tetzlaff, WF
   Brites, F
AF Hirschler, Valeria
   Martin, Maximiliano
   Molinari, Claudia
   Botta, Eliana
   Francisco Tetzlaff, Walter
   Brites, Fernando
TI Activity of Lipoprotein-Associated Enzymes in Indigenous Children Living
   at Different Altitudes
SO ARCHIVES OF MEDICAL RESEARCH
LA English
DT Article
DE Indigenous school children; Paraoxonase 1; Cholesteryl Transfer Protein;
   High Altitude; Hypoxia; Oxidative Stress
ID LIFE-STYLE BEHAVIORS; DENSITY-LIPOPROTEIN; CARDIOVASCULAR-DISEASE;
   MYOCARDIAL-INFARCTION; CARDIOMETABOLIC RISK; INVERSE ASSOCIATION;
   OXIDATIVE STRESS; LEPTIN LEVELS; CHOLESTEROL; OBESITY
AB Background. High altitude is associated with hypobaric hypoxia, and metabolic modifications. In particular, alterations to lipoprotein-associated enzymes have been reported under hypoxia.
   Objective. To determine the association between paraoxonase 1 (PON-1) and Cholesteryl-ester transfer protein (CETP) activities and altitude in two groups of Argentinean Indigenous schoolchildren living at different altitudes.
   Methods. A cross-sectional study compared 151 schoolchildren from San Antonio de los Cobres (SAC), 3,750 m, with 175 schoolchildren from Chicoana (CH), 1,400 m. Anthropometric data, lipids, apolipoprotein (apo) A-I, apo B, plus PON-1 and CETP activities were determined.
   Results. The prevalence of overweight/obesity was significantly lower in SAC than in CH. Z- BMI (0.3 vs 0.7), Apo A-I/Apo B (1.67 vs. 1.85) and PON-1 (170 vs. 243 nmol/mL.min) were significantly lower in SAC than in CH, respectively. Total cholesterol (156 vs 144 mg/dL), triglycerides (TG) (119 vs. 94 mg/dL), apo A-I (133 vs. 128 mg/dL), apo B (84 vs. 73 mg/dL), hematocrit (48 vs. 41%), transferrin (295 vs. 260 mg/dL) and CETP (181 vs. 150%/mL.h) were significantly higher in SAC than in CH. There was a significant univariate association between altitude and transferrin (r0.38), hematocrit (r0.75), TG (r0.24), apo B (r0.29), PON-1 (r-0.40), and CETP (r0.37). Multiple linear regression analyses showed that altitude was significantly associated with children's TG (beta = 0.28, R-2 = 0.14), HDL-C (beta = 0.27; R-2 = 0.23), apo B (beta = 0.32; R-2 = 0.14), CETP (beta = 0.38; R-2 = 0.15) and PON-1 (beta = -0.36; R-2 = 0.16), adjusted for age, gender and BMI.
   Conclusion. SAC children presented a more atherogenic lipid profile, plus lower PON1 and higher CETP activities, than CH children. (C) 2019 IMSS. Published by Elsevier Inc.
C1 [Hirschler, Valeria; Molinari, Claudia] Univ Buenos Aires, Nutr, Maipu 812, Buenos Aires, DF, Argentina.
   [Martin, Maximiliano; Botta, Eliana; Francisco Tetzlaff, Walter; Brites, Fernando] Univ Buenos Aires, CONICET, Sch Pharm & Biochem, Lab Lipids & Athemsclerosis,Dept Clin Biochem, Buenos Aires, DF, Argentina.
C3 University of Buenos Aires; Consejo Nacional de Investigaciones
   Cientificas y Tecnicas (CONICET); University of Buenos Aires
RP Hirschler, V (corresponding author), Univ Buenos Aires, Nutr, Maipu 812, Buenos Aires, DF, Argentina.
EM vhirschler@gmail.com
RI Evelson, Pablo/J-1245-2014
OI Martin, Maximiliano/0000-0002-8555-9174; Hirschler,
   Valeria/0000-0002-9533-9343; Tetzlaff, Walter
   Francisco/0000-0003-2705-7683
FU University of Buenos Aires [UBACyT CB23]; CONICET [PIP 516]; ANPCyT
   [PICT 2016-2018]
FX The present study was primarily supported by grants from the University
   of Buenos Aires (UBACyT CB23), CONICET (PIP 516) and ANPCyT (PICT
   2016-2018).
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NR 45
TC 2
Z9 2
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0188-4409
EI 1873-5487
J9 ARCH MED RES
JI Arch. Med. Res.
PD APR
PY 2019
VL 50
IS 3
BP 98
EP 104
DI 10.1016/j.arcmed.2019.07.001
PG 7
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA IZ6CA
UT WOS:000487168200004
PM 31495396
DA 2025-06-11
ER

PT J
AU Bleil, ME
   Spieker, SJ
   Gregorich, SE
   Thomas, AS
   Hiatt, RA
   Appelhans, BM
   Roisman, GI
   Booth-LaForce, C
AF Bleil, Maria E.
   Spieker, Susan J.
   Gregorich, Steven E.
   Thomas, Alexis S.
   Hiatt, Robert A.
   Appelhans, Bradley M.
   Roisman, Glenn, I
   Booth-LaForce, Cathryn
TI Early Life Adversity and Pubertal Timing: Implications for
   Cardiometabolic Health
SO JOURNAL OF PEDIATRIC PSYCHOLOGY
LA English
DT Article
DE cardiometabolic disease; chronic illness; endocrinology; family
   functioning; health behavior; health promotion and prevention;
   longitudinal research; obesity; parenting; prevention/control;
   psychosocial functioning; pubertal timing; stress
AB Objective To identify early life adversity (ELA) risk factors for earlier pubertal timing, itself a risk factor for poor cardiometabolic health, and to determine whether such ELA-related risk may be mediated by pre-pubertal body mass index (BMI). Methods Subjects included 426 female participants in a prospective birth cohort study, the NICHD Study of Early Child Care and Youth Development. Survival analysis models were fit to examine ELA exposures, representing childhood socioeconomic status (SES), maternal sensitivity, mother-child attachment, and negative life events, along with child health indicators and covariates, in relation to pubertal timing outcomes, including age at menarche and ages at Tanner stage II for breast and pubic hair development. Results Higher childhood SES emerged as an independent predictor of older age at menarche, showing each one standard deviation increase in childhood SES corresponded to a 1.3% increase in age at menarche (factor change = 1.013; 1.003-1.022; p < .01), but did not predict breast or pubic hair development (ps >.05). In mediation analyses, indirect (mediated) effects of mother-child attachment on the pubertal timing outcomes, via pre-pubertal BMI, were all statistically significant (ps < .05). Conclusions Higher childhood SES predicted directly, and secure (vs. insecure) mother-child attachment predicted indirectly (via pre-pubertal BMI), later pubertal timing, suggesting these factors may protect girls from earlier pubertal development. By extension, clinical implications are that intervention strategies designed to lessen ELA- and pre-pubertal obesity-related risk may be effective in remediating life course pathways linking ELA, accelerated pubertal development, and cardiometabolic risk.
C1 [Bleil, Maria E.; Spieker, Susan J.; Thomas, Alexis S.; Booth-LaForce, Cathryn] Univ Washington, Child Family & Populat Hlth Nursing, Seattle, WA 98195 USA.
   [Gregorich, Steven E.] Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA.
   [Hiatt, Robert A.] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA USA.
   [Appelhans, Bradley M.] Rush Univ, Div Behav Sci, Chicago, IL USA.
   [Roisman, Glenn, I] Univ Minnesota, Inst Child Dev, 51 E River Rd, Minneapolis, MN 55455 USA.
C3 University of Washington; University of Washington Seattle; University
   of California System; University of California San Francisco; University
   of California System; University of California San Francisco; Rush
   University; University of Minnesota System; University of Minnesota Twin
   Cities
RP Bleil, ME (corresponding author), Univ Washington, Dept Child Family & Populat Hlth Nursing, Box 357262, Seattle, WA 98195 USA.
EM mbleil@uw.edu
RI Hiatt, Robert/AAQ-1537-2021
FU Eunice Kennedy Shriver National Institute of Child Health and Human
   Development at the National Institutes of Health [U10HD025447,
   R01HD091132]; National Heart, Lung, and Blood Institute at the National
   Institutes of Health [R01HL130103]
FX This work was supported by the Eunice Kennedy Shriver National Institute
   of Child Health and Human Development (U10HD025447, R01HD091132) and the
   National Heart, Lung, and Blood Institute (R01HL130103) at the National
   Institutes of Health.
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NR 77
TC 18
Z9 18
U1 1
U2 6
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0146-8693
EI 1465-735X
J9 J PEDIATR PSYCHOL
JI J. Pediatr. Psychol.
PD JAN-FEB
PY 2021
VL 46
IS 1
BP 36
EP 48
DI 10.1093/jpepsy/jsaa082
PG 13
WC Psychology, Developmental
WE Social Science Citation Index (SSCI)
SC Psychology
GA RJ0RZ
UT WOS:000637312100005
PM 33120426
OA Green Published
DA 2025-06-11
ER

PT J
AU Rajesh, T
   Lakshmi, KS
   Sharma, S
   Reddy, PD
   Lakshmi, S
AF Rajesh, Tirumala
   Lakshmi, Karunanidhi Santhana
   Sharma, Shrinivas
   Reddy, Pulukurthy Dileep
   Lakshmi, Sivasubramanian
TI Use of a Validated Stability-Indicating HPTLC Method to Study the
   Degradation of Rimonabant
SO JPC-JOURNAL OF PLANAR CHROMATOGRAPHY-MODERN TLC
LA English
DT Article
DE Rimonabant; HPTLC; Stress-degradation; Validation; Stability-indicating;
   Degradation kinetics
ID CANNABINOID CB1; RECEPTOR ANTAGONISM; PHARMACOLOGY; SR141716A
AB Rimonabant (RIM) is a synthetic cannabinoid CB, receptor antagonist being developed for the treatment of multiple cardiometabolic risk factors, including abdominal obesity and smoking. This paper describes development and subsequent validation, in accordance with International Conference on Harmonization (ICH) guidelines, of a simple, sensitive, selective, precise, and stability-indicating HPTLC method for analysis of rimonabant. Silica gel plates were used with methanol water 7:3 (v/v) as mobile phase. Densitometry was performed at 250 nm. Compact bands were obtained at R, 0.71 +/- 0.02. Linear regression analysis of calibration data revealed good linear relationship with r(2) = 0.9985 in the working concentration range of 100-800 ng per band. The method was validated for precision, accuracy, ruggedness, robustness, specificity and recovery. The drug was subjected to acidic and alkaline hydrolysis, oxidation, dry heat, UV irradiation, and photodegradation in daylight. The peaks of degradation products were well resolved from that of the drug with significantly different R-F values. Statistical analysis showed the method is reproducible and selective. Because the method effectively separates the drug from its degradation products, it can be regarded as stability-indicating. The method enabled successful analysis of marketed formulations of rimonabant and was also used to investigate the kinetics of acidic and alkaline degradation at different temperatures. An Arrhenius plot was constructed and apparent pseudo-first-order rate constant, half-life, and activation energy were calculated. The pH rate profile for degradation of rimonabant in constant-ionic-strength buffer solutions was studied in the pH range 1.2-10.8.
C1 [Rajesh, Tirumala; Lakshmi, Karunanidhi Santhana; Lakshmi, Sivasubramanian] SRM Univ, SRM Coll Pharm, Dept Pharmaceut Anal, Kattankulathur 603203, Tamil Nadu, India.
   [Reddy, Pulukurthy Dileep] SRM Univ, SRM Coll Pharm, Dept Pharmacol, Kattankulathur 603203, Tamil Nadu, India.
C3 SRM Institute of Science & Technology Chennai; SRM Institute of Science
   & Technology Chennai
RP Rajesh, T (corresponding author), SRM Univ, SRM Coll Pharm, Dept Pharmaceut Anal, Kattankulathur 603203, Tamil Nadu, India.
EM rajeshtirumala@hotmail.com
RI K, Lakshmi/MBV-8497-2025; SIVASUBRAMANIAN, LAKSHMI/ABG-5045-2021
OI SIVASUBRAMANIAN, LAKSHMI/0000-0002-2460-0073
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NR 32
TC 1
Z9 1
U1 0
U2 3
PU AKADEMIAI KIADO ZRT
PI BUDAPEST
PA BUDAFOKI UT 187-189-A-3, H-1117 BUDAPEST, HUNGARY
SN 0933-4173
EI 1789-0993
J9 JPC-J PLANAR CHROMAT
JI JPC-J. Planar Chromatogr.-Mod. TLC
PD APR
PY 2010
VL 23
IS 2
BP 148
EP 155
DI 10.1556/JPC.23.2010.2.12
PG 8
WC Chemistry, Analytical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry
GA 601AW
UT WOS:000278031400012
DA 2025-06-11
ER

PT J
AU Menni, C
   Louca, P
   Berry, SE
   Vijay, A
   Astbury, S
   Leeming, ER
   Gibson, R
   Asnicar, F
   Piccinno, G
   Wolf, J
   Davies, R
   Mangino, M
   Segata, N
   Spector, TD
   Valdes, AM
AF Menni, Cristina
   Louca, Panayiotis
   Berry, Sarah E.
   Vijay, Amrita
   Astbury, Stuart
   Leeming, Emily R.
   Gibson, Rachel
   Asnicar, Francesco
   Piccinno, Gianmarco
   Wolf, Jonathan
   Davies, Richard
   Mangino, Massimo
   Segata, Nicola
   Spector, Tim D.
   Valdes, Ana M.
TI High intake of vegetables is linked to lower white blood cell profile
   and the effect is mediated by the gut microbiome
SO BMC MEDICINE
LA English
DT Article
DE White blood cell; Gut microbiome; Diet; Vegetable intake; Chronic
   inflammation
ID INORGANIC NITRATE; DIETARY NITRATE; OXIDATIVE STRESS; INFLAMMATION;
   DISEASE; NITRITE; SUPPLEMENTATION; RECRUITMENT; DYSFUNCTION; METABOLISM
AB Background: Chronic inflammation, which can be modulated by diet, is linked to high white blood cell counts and correlates with higher cardiometabolic risk and risk of more severe infections, as in the case of COVID-19.
   Methods: Here, we assessed the association between white blood cell profile (lymphocytes, basophils, eosinophils, neutrophils, monocytes and total white blood cells) as markers of chronic inflammation, habitual diet and gut microbiome composition (determined by sequencing of the 16S RNA) in 986 healthy individuals from the PREDICT-1 nutritional intervention study. We then investigated whether the gut microbiome mediates part of the benefits of vegetable intake on lymphocyte counts.
   Results: Higher levels of white blood cells, lymphocytes and basophils were all significantly correlated with lower habitual intake of vegetables, with vegetable intake explaining between 3.59 and 6.58% of variation in white blood cells after adjusting for covariates and multiple testing using false discovery rate (q < 0.1). No such association was seen with fruit intake. A mediation analysis found that 20.00% of the effect of vegetable intake on lymphocyte counts was mediated by one bacterial genus, Collinsella, known to increase with the intake of processed foods and previously associated with fatty liver disease. We further correlated white blood cells to other inflammatory markers including IL6 and GlycA, fasting and post-prandial glucose levels and found a significant relationship between inflammation and diet.
   Conclusion: A habitual diet high in vegetables, but not fruits, is linked to a lower inflammatory profile for white blood cells, and a fifth of the effect is mediated by the genus Collinsella.
C1 [Menni, Cristina; Louca, Panayiotis; Leeming, Emily R.; Mangino, Massimo; Spector, Tim D.; Valdes, Ana M.] Kings Coll London, Dept Twin Res & Genet Epidemiol, St Thomas Hosp Campus,Westminster Bridge Rd, London SE1 7EH, England.
   [Berry, Sarah E.; Gibson, Rachel] Kings Coll London, Dept Nutr Sci, Franklin Wilkins Bldg,Stamford St, London SE1 9NH, England.
   [Vijay, Amrita; Astbury, Stuart; Valdes, Ana M.] Univ Nottingham, Nottingham City Hosp, Sch Med, Acad Rheumatol Clin Sci Bldg,Hucknall Rd, Nottingham NG5 1PB, England.
   [Vijay, Amrita; Astbury, Stuart; Valdes, Ana M.] Nottingham Univ Hosp NHS Trust, Natl Inst Hlth Res NIHR Nottingham Biomed Res Ctr, Nottingham, England.
   [Vijay, Amrita; Astbury, Stuart; Valdes, Ana M.] Univ Nottingham, Nottingham, England.
   [Asnicar, Francesco; Piccinno, Gianmarco; Segata, Nicola] Univ Trento, Dept CIBIO, Via Sommar 9, I-38123 Trento, Italy.
   [Wolf, Jonathan; Davies, Richard] Zoe Global Ltd, 164 Westminster Bridge Rd, London SE1 7RW, England.
   [Mangino, Massimo] Guys & St Thomas Fdn Trust, NIHR Biomed Res Ctr, London SE1 9RT, England.
C3 University of London; King's College London; University of London;
   King's College London; Nottingham University Hospital NHS Trust;
   Nottingham City Hospital; University of Nottingham; Nottingham
   University Hospital NHS Trust; University of Nottingham; University of
   Trento; Guy's & St Thomas' NHS Foundation Trust
RP Menni, C; Valdes, AM (corresponding author), Kings Coll London, Dept Twin Res & Genet Epidemiol, St Thomas Hosp Campus,Westminster Bridge Rd, London SE1 7EH, England.; Valdes, AM (corresponding author), Univ Nottingham, Nottingham City Hosp, Sch Med, Acad Rheumatol Clin Sci Bldg,Hucknall Rd, Nottingham NG5 1PB, England.; Valdes, AM (corresponding author), Nottingham Univ Hosp NHS Trust, Natl Inst Hlth Res NIHR Nottingham Biomed Res Ctr, Nottingham, England.
EM cristina.menni@kcl.ac.uk; Ana.Valdes@nottingham.ac.uk
RI Valdes, Ana/AFK-8052-2022; Asnicar, Francesco/AAB-9255-2020; Louca,
   Panayiotis/AAE-4325-2022; Piccinno, Gianmarco/N-4062-2016; Segata,
   Nicola/K-7240-2016; Menni, Cristina/JLL-2864-2023; mangino,
   massimo/F-5134-2011
OI Astbury, Stuart/0000-0002-1919-3952; Vijay, Amrita/0000-0002-9595-5680;
   Piccinno, Gianmarco/0000-0003-1947-1817; Louca,
   Panayiotis/0000-0001-5956-1433; Segata, Nicola/0000-0002-1583-5794;
   Gibson, Rachel/0000-0002-5823-6468; Menni, Cristina/0000-0001-9790-0571;
   Berry, Sarah/0000-0002-5819-5109; Valdes, Ana M./0000-0003-1141-4471;
   mangino, massimo/0000-0002-2167-7470
FU Zoe Global; Wellcome Trust [212904/Z/18/Z]; Medical Research Council
   (MRC)/British Heart Foundation Ancestry and Biological Informative
   Markers for Stratification of Hypertension (AIMHY) [MR/M016560/1];
   Medical Research Council; European Union; Chronic Disease Research
   Foundation (CDRF); National Institute for Health Research (NIHR); King's
   College London; MRC AIMHY grant; Chronic Disease Research Foundation;
   BBSRC [BB/NO12739/1]; European Research Council (ERC-STG project
   MetaPG); European H2020 program [ONCOBIOME-825410, MASTER-818368];
   National Cancer Institute of the National Institutes of Health
   [1U01CA230551]; National Institute for Health Research Nottingham
   Biomedical Research Centre; MRC [MR/N01183X/1] Funding Source: UKRI
FX This work was supported by Zoe Global and also received support from
   grants from the Wellcome Trust (212904/Z/18/Z) and the Medical Research
   Council (MRC)/British Heart Foundation Ancestry and Biological
   Informative Markers for Stratification of Hypertension (AIMHY;
   MR/M016560/1). TwinsUK is funded by the Wellcome Trust, Medical Research
   Council, European Union, Chronic Disease Research Foundation (CDRF), Zoe
   Global and the National Institute for Health Research (NIHR)-funded
   BioResource, Clinical Research Facility and Biomedical Research Centre
   based at Guy's and St Thomas' NHS Foundation Trust in partnership with
   King's College London. CM was supported by the MRC AIMHY grant and by
   the Chronic Disease Research Foundation. PB was supported by the Chronic
   Disease Research Foundation. SEB was supported in part by a grant funded
   by the BBSRC (BB/NO12739/1). NS received support from the European
   Research Council (ERC-STG project MetaPG), the European H2020 program
   (ONCOBIOME-825410 project and MASTER-818368 project) and the National
   Cancer Institute of the National Institutes of Health (1U01CA230551).
   AMV was supported by the National Institute for Health Research
   Nottingham Biomedical Research Centre.
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NR 55
TC 36
Z9 37
U1 0
U2 7
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1741-7015
J9 BMC MED
JI BMC Med.
PD FEB 11
PY 2021
VL 19
IS 1
AR 37
DI 10.1186/s12916-021-01913-w
PG 10
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA QF8FP
UT WOS:000617126400001
PM 33568158
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Medina-Gomez, G
   Yetukuri, L
   Velagapudi, V
   Campbell, M
   Blount, M
   Jimenez-Linan, M
   Ros, M
   Oresic, M
   Vidal-Puig, A
AF Medina-Gomez, Gema
   Yetukuri, Laxman
   Velagapudi, Vidya
   Campbell, Mark
   Blount, Margaret
   Jimenez-Linan, Mercedes
   Ros, Manuel
   Oresic, Matej
   Vidal-Puig, Antonio
TI Adaptation and failure of pancreatic β cells in murine models with
   different degrees of metabolic syndrome
SO DISEASE MODELS & MECHANISMS
LA English
DT Article
ID ENDOPLASMIC-RETICULUM STRESS; ELEMENT-BINDING PROTEIN-1C; INSULIN
   GENE-TRANSCRIPTION; PYRUVATE-CARBOXYLASE; OXIDATIVE STRESS; CHRONIC
   EXPOSURE; CYCLE ARREST; MALONYL-COA; ER STRESS; GLUCOSE
AB The events that contribute to the expansion of beta-cell mass and enhanced beta-cell function in insulin-resistant states have not been elucidated fully. Recently, we showed that beta-cell adaptation failed dramatically in adult, insulin-resistant POKO mice, which contrasts with the appropriate expansion of beta cells in their ob/ob littermates. Thus, we hypothesised that characterisation of the islets in these mouse models at an early age should provide a unique opportunity to: (1) identify mechanisms involved in sensing insulin resistance at the level of the beta cells, (2) identify molecular effectors that contribute to increasing beta-cell mass and function, and (3) distinguish primary events from secondary events that are more likely to be present at more advanced stages of diabetes. Our results define the POKO mouse as a model of early lipotoxicity. At 4 weeks of age, it manifests with inappropriate beta-cell function and defects in proliferation markers. Other well-recognised pathogenic effectors that were observed previously in 16-week-old mice, such as increased reactive oxygen species (ROS), macrophage infiltration and endoplasmic reticulum (ER) stress, are also present in both young POKO and young ob/ob mice, indicating the lack of predictive power with regards to the severity of beta-cell failure. Of interest, the relatively preserved lipidomic profile in islets from young POKO mice contrasted with the large changes in lipid composition and the differences in the chain length of triacylglycerols in the serum, liver, muscle and adipose tissue in adult POKO mice. Later lipotoxic insults in adult beta cells contribute to the failure of the POKO beta cell. Our results indicate that the rapid development of insulin resistance and beta-cell failure in POKO mice makes this model a useful tool to study early molecular events leading to insulin resistance and beta-cell failure. Furthermore, comparisons with ob/ob mice might reveal important adaptive mechanisms in beta cells with either therapeutic or diagnostic potential.
C1 [Medina-Gomez, Gema; Campbell, Mark; Blount, Margaret; Ros, Manuel; Vidal-Puig, Antonio] Univ Cambridge, Addenbrookes Hosp, Metab Res Labs, Inst Metab Sci, Cambridge CB2 0QQ, England.
   [Yetukuri, Laxman; Velagapudi, Vidya; Oresic, Matej] VTT Tech Res Ctr Finland, FIN-02044 Espoo, Vtt, Finland.
   [Jimenez-Linan, Mercedes] Univ Cambridge, Addenbrookes Hosp, Dept Histopathol, Cambridge CB2 0QQ, England.
C3 University of Cambridge; Cambridge University Hospitals NHS Foundation
   Trust; Addenbrooke's Hospital; VTT Technical Research Center Finland;
   University of Cambridge; Cambridge University Hospitals NHS Foundation
   Trust; Addenbrooke's Hospital
RP Medina-Gomez, G (corresponding author), Univ Rey Juan Carlos, Fac Ciencias Salud, Dept Bioquim Fisiol & Genet Mol, Avda Atenas S-N, Madrid 28922, Spain.
EM gema.medina@urjc.es; ajv22@cam.ac.uk
RI Oresic, Matej/K-7673-2016; Velagapudi, Vidya/L-7278-2015; Ros Lasierra,
   Maria Angeles/K-8160-2014; Medina-Gomez, Gema/F-5667-2016
OI Ros, Manuel/0000-0003-2982-513X; Velagapudi, Vidya/0000-0002-8261-7164;
   Vidal-Puig, Antonio/0000-0003-4220-9577; Ros Lasierra, Maria
   Angeles/0000-0002-1224-7671; Medina-Gomez, Gema/0000-0001-8169-681X
FU Diabetes UK; FP6 Hepadip; MRC; MRC CORD; MEC, Spain; MRC [G0600717,
   G0400192] Funding Source: UKRI
FX We thank Keith Burling, Janice Carter and Daniel Hart for their work. We
   thank Sophie Gough, Maria Adams and Sergio Rodriguez-Cuenca for their
   comments on the writing of this manuscript. We thank the funding bodies
   that have supported the research within our laboratory leading to this
   work: Diabetes UK, FP6 Hepadip, and the MRC career establishment award
   and MRC CORD. Manuel Ros is a recipient of a Salvador de Madariaga
   fellowship from MEC, Spain. Deposited in PMC for release after 6 months.
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NR 44
TC 31
Z9 35
U1 0
U2 5
PU COMPANY BIOLOGISTS LTD
PI CAMBRIDGE
PA BIDDER BUILDING, STATION RD, HISTON, CAMBRIDGE CB24 9LF, ENGLAND
SN 1754-8403
EI 1754-8411
J9 DIS MODEL MECH
JI Dis. Model. Mech.
PD NOV-DEC
PY 2009
VL 2
IS 11-12
BP 582
EP 592
DI 10.1242/dmm.003251
PG 11
WC Cell Biology; Medicine, Research & Experimental; Pathology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Research & Experimental Medicine; Pathology
GA 533OF
UT WOS:000272832900011
PM 19841237
OA Green Published
DA 2025-06-11
ER

PT J
AU Schinke, C
   Hesse, S
   Rullmann, M
   Becker, GA
   Luthardt, J
   Zientek, F
   Patt, M
   Stoppe, M
   Schmidt, E
   Meyer, K
   Meyer, PM
   Orthgie, J
   Blüher, M
   Kratzsch, J
   Ding, YS
   Bergh, FT
   Sabri, O
AF Schinke, Christian
   Hesse, Swen
   Rullmann, Michael
   Becker, Georg-Alexander
   Luthardt, Julia
   Zientek, Franziska
   Patt, Marianne
   Stoppe, Muriel
   Schmidt, Elisa
   Meyer, Klara
   Meyer, Philipp M.
   Orthgie, Johannes
   Blueher, Matthias
   Kratzsch, Juergen
   Ding, Yu-Shin
   Bergh, Florian Then
   Sabri, Osama
TI Central noradrenaline transporter availability is linked with HPA axis
   responsiveness and copeptin in human obesity and non-obese controls
SO STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS
LA English
DT Article
DE Noradrenaline transporter (NAT); PET; obesity; dexamethasone; CRH test;
   stress; cortisol; copeptin
ID PITUITARY-ADRENAL AXIS; CORTICOTROPIN-RELEASING-FACTOR; MAJOR DEPRESSIVE
   DISORDER; NOREPINEPHRINE TRANSPORTER; METABOLIC SYNDROME; PREFRONTAL
   CORTEX; PLASMA COPEPTIN; STRESS; CORTISOL; SYSTEM
AB The central noradrenaline (NA) stress-response network co-mediates hypothalamic-pituitary-adrenal (HPA) axis activation and arginine-vasopressin (AVP) release. Dysregulation of these systems contributes to stress-related diseases such as human obesity, but their interrelation remains unclear. The study was aimed to test for the first time in vivo whether central noradrenergic activity quantitatively indexed by the availability of the presynaptic NA transporter (NAT) is associated with HPA axis responsiveness as measured with the combined dexamethasone suppression/corticotropin releasing hormone stimulation (dex/CRH) test and copeptin as a surrogate marker of the serum AVP tone in highly obese, otherwise, healthy individuals compared to age- and sex-matched non-obese, healthy controls. In order to assess central NAT availability, positron emission tomography (PET) was applied using the NAT-selective radiotracer S,S-[C-11]O-methylreboxetine (MRB) and correlated with curve indicators derived from the dex/CRH test (maximum, MAX, and area under the curve, AUC, for cortisol and adrenocorticotropic hormone, ACTH) as well as with copeptin. In non-obese controls, positive correlations were found between the NAT distribution volume ratios (DVR) of the orbitofrontal cortex (OFC) and the amygdala with the HPA response (OFC: ACTH(MAX) r = 0.87, p = .001; cortisol(MAX) r = 0.86, p = .002; amygdala: ACTH(MAX) r = 0.86, p = .002; cortisol(MAX) r = 0.79, p = .006), while in obesity, the hypothalamic DVR correlated inversely with the HPA axis response (cortisol(MAX), r = -0.66, p = .04) and with copeptin (r = -0.71, p = .02). This association of central NAT availability with HPA axis responsiveness and copeptin suggests a mechanistic interaction between noradrenergic transmission with HPA axis activity and the serum AVP system that differs between non-obese individuals with prefrontal-limbic involvement and obesity with a hypothalamic-centered relationship. Whether the latter finding contributes to obesogenic behavior needs to be further explored.
C1 [Schinke, Christian; Hesse, Swen; Rullmann, Michael; Zientek, Franziska; Sabri, Osama] Univ Leipzig, Med Ctr, Integrated Res & Treatment Ctr IFB Adipos Dis, Leipzig, Germany.
   [Schinke, Christian; Stoppe, Muriel; Schmidt, Elisa; Meyer, Klara; Orthgie, Johannes; Bergh, Florian Then] Univ Leipzig, Dept Neurol, Leipzig, Germany.
   [Schinke, Christian] Charite Univ Med Berlin, Berlin, Germany.
   [Schinke, Christian] Free Univ Berlin, Berlin, Germany.
   [Schinke, Christian] Humboldt Univ, Berlin, Germany.
   [Schinke, Christian] Berlin Inst Hlth, Klin & Hochschulambulanz Neurol, Berlin, Germany.
   [Hesse, Swen; Rullmann, Michael; Becker, Georg-Alexander; Luthardt, Julia; Zientek, Franziska; Patt, Marianne; Meyer, Philipp M.; Sabri, Osama] Univ Leipzig, Dept Nucl Med, Leipzig, Germany.
   [Stoppe, Muriel; Bergh, Florian Then] Univ Leipzig, Translat Ctr Regenerat Med, Leipzig, Germany.
   [Blueher, Matthias] Univ Leipzig, Dept Internal Med, Leipzig, Germany.
   [Kratzsch, Juergen] Univ Leipzig, Inst Lab Med Clin Chem & Mol Diagnost, Leipzig, Germany.
   [Ding, Yu-Shin] NYU, Dept Radiol, Sch Med, 560 1St Ave, New York, NY 10016 USA.
   [Ding, Yu-Shin] NYU, Sch Med, Dept Psychiat, New York, NY USA.
C3 Leipzig University; Leipzig University; Berlin Institute of Health; Free
   University of Berlin; Humboldt University of Berlin; Charite
   Universitatsmedizin Berlin; Free University of Berlin; Humboldt
   University of Berlin; Berlin Institute of Health; Leipzig University;
   Leipzig University; Leipzig University; Leipzig University; New York
   University; New York University
RP Hesse, S (corresponding author), Univ Leipzig, Med Ctr, Integrated Res & Treatment Ctr IFB Adipos Dis, Leipzig, Germany.
EM swen.hesse@medizin.uni-leipzig.de
OI Hesse, Swen/0000-0002-2055-2764; Sabri, Osama/0000-0002-6425-3504;
   Rullmann, Michael/0000-0002-2683-9432; Schinke,
   Christian/0000-0003-0199-9672
FU IFB AdiposityDiseases, Federal Ministry of Education and Research
   (BMBF), Germany [01E01001]; TRM, by the German Federal Ministry of
   Education and Research [BMBF 1315883]
FX The work is supported by the IFB AdiposityDiseases, Federal Ministry of
   Education and Research (BMBF), Germany, FKZ: [01E01001]
   (http://www.bmbf.de).MS and FTB were funded, in part, through TRM, by
   the German Federal Ministry of Education and Research [BMBF 1315883].
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NR 52
TC 11
Z9 12
U1 0
U2 5
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1025-3890
EI 1607-8888
J9 STRESS
JI Stress
PD JAN 2
PY 2019
VL 22
IS 1
BP 93
EP 102
DI 10.1080/10253890.2018.1511698
PG 10
WC Behavioral Sciences; Endocrinology & Metabolism; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Behavioral Sciences; Endocrinology & Metabolism; Neurosciences &
   Neurology
GA HS4TU
UT WOS:000463861400011
PM 30369292
DA 2025-06-11
ER

PT J
AU Chang, SH
   Wu, LS
   Chiou, MJ
   Liu, JR
   Yu, KH
   Kuo, CF
   Wen, MS
   Chen, WJ
   Yeh, YH
   See, LC
AF Chang, Shang-Hung
   Wu, Lung-Sheng
   Chiou, Meng-Jiun
   Liu, Jia-Rou
   Yu, Kuang-Hui
   Kuo, Chang-Fu
   Wen, Ming-Shien
   Chen, Wei-Jan
   Yeh, Yung-Hsin
   See, Lai-Chu
TI Association of metformin with lower atrial fibrillation risk among
   patients with type 2 diabetes mellitus: a population-based dynamic
   cohort and in vitro studies
SO CARDIOVASCULAR DIABETOLOGY
LA English
DT Article
DE Metformin; Atrial fibrillation; Myolysis; Oxidative stress; Diabetes
   mellitus
ID METABOLIC SYNDROME; INSULIN-RESISTANCE; OXIDATIVE STRESS;
   THIAZOLIDINEDIONES; INFLAMMATION; ATHEROSCLEROSIS; ACTIVATION;
   EXPRESSION; ADULTS; CELLS
AB Background: Atrial fibrillation (AF), an inflammatory process involving arrhythmia, is associated with severe morbidity and mortality and commonly seen in patients with diabetes mellitus (DM). The effect of metformin, the most commonly used medication for patients with DM, on AF has not been investigated. The primary aim of this study was to examine whether metformin prevented the occurrence of AF in type 2 DM patients by analyzing a nationwide, population-based dynamic cohort. Additionally, we investigated the effect of metformin on tachycardia-induced myolysis and oxidative stress in atrial cells.
   Methods: The study population included 645,710 patients with type 2 diabetes and not using other anti-diabetic medication from a subset of the Taiwan National Health Insurance Research Database. Of these patients, those who used metformin were categorized as the user group, and the remaining were classified as the non-user group. The time-dependent Cox's proportional hazard model was used to examine the effect of metformin on AF and the status of metformin use was treated as a time-dependent covariate. HL-1 atrial cells were paced with or without metformin, and then troponin and heavy-chain-myosin were measured as markers of myolysis.
   Results: After 13 years of follow-up, 9,983 patients developed AF with an incidence rate of 1.5% (287 per 100,000 person-years). After adjusting for co-morbidities and medications, metformin independently protected the diabetic patients from new-onset AF with a hazard ratio of .81 (95% confidence interval 0.76-0.86, p < 0.0001). Metformin significantly decreased the extent of pacing-induced myolysis and the production of reactive oxygen species.
   Conclusion: Metformin use was associated with a decreased risk of AF in patients with type 2 DM who were not using other anti-diabetic medication, probably via attenuation of atrial cell tachycardia-induced myolysis and oxidative stress.
C1 [Chang, Shang-Hung; Wu, Lung-Sheng; Wen, Ming-Shien; Chen, Wei-Jan; Yeh, Yung-Hsin] Chang Gung Univ, Taoyuan 333, Taiwan.
   [Chang, Shang-Hung; Wu, Lung-Sheng; Wen, Ming-Shien; Chen, Wei-Jan; Yeh, Yung-Hsin] Chang Gung Mem Hosp, Dept Cardiol, Taoyuan 333, Taiwan.
   [Chiou, Meng-Jiun; Liu, Jia-Rou; See, Lai-Chu] Chang Gung Univ, Dept Publ Hlth, Coll Med, Taoyuan 333, Taiwan.
   [Yu, Kuang-Hui; Kuo, Chang-Fu] Chang Gung Mem Hosp, Dept Rheumatol Allergy & Immunol, Kweishan 333, Taiwan.
   [See, Lai-Chu] Chang Gung Univ, Mol Med Res Ctr, Biostat Core Lab, Kweishan 333, Taiwan.
C3 Chang Gung University; Chang Gung Memorial Hospital; Chang Gung
   University; Chang Gung Memorial Hospital; Chang Gung University
RP Yeh, YH (corresponding author), Chang Gung Univ, Taoyuan 333, Taiwan.
EM yeongshinn@adm.cgmh.org.tw; lichu@mail.cgu.edu.tw
RI Chiou, Meng-Jiun/GPG-1381-2022; Kuo, Chang-Fu/Q-1714-2016; Hung,
   yu-chiang/ABE-7636-2020; Yeh, Yung-Hsin/ABD-9351-2021
OI See, Lai-Chu/0000-0002-1379-8969; Chang, Shang-hung/0000-0003-0462-2344
FU Chang-Gung Memorial Hospital [CMRPG391113, CMRPG3A0641, CMRPG3B1691-3,
   CMRPG3A0571-3]; Ministry of Science and Technology
   [102-2628-B-182-011-MY3]
FX This work was supported by grants from Chang-Gung Memorial Hospital
   (CMRPG391113, CMRPG3A0641, CMRPG3B1691-3, and CMRPG3A0571-3) and
   Ministry of Science and Technology (102-2628-B-182-011-MY3).
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NR 31
TC 165
Z9 173
U1 0
U2 11
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1475-2840
J9 CARDIOVASC DIABETOL
JI Cardiovasc. Diabetol.
PD AUG 10
PY 2014
VL 13
AR 123
DI 10.1186/s12933-014-0123-x
PG 8
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism
GA AU1CQ
UT WOS:000345359200001
PM 25106079
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Zeng, KW
   Gu, MY
AF Zeng, Ke-Wu
   Gu, Ming-Yao
TI Annual advances of integrative pharmacology in 2019
SO TRADITIONAL MEDICINE RESEARCH
LA English
DT Review
DE Traditional medicine; Natural product; Pharmacology; Cancer;
   Inflammation; Infectious diseases
ID INHIBITION
AB Representative studies concerning the pharmacology of traditional medicine and active herbal products have been summarized over the past 12 months. This annual integrative pharmacology review encompasses research articles published during 2019 on the bioactive compounds and extracts used in traditional medicine. Reports highlighting the pharmacology progress of traditional medicine were specifically introduced, including artemisinin for cancer cell sensibility and induction to ferroptosis, rutin for neuroinflammation suppression, Ginseng Radix et Rhizoma for gut microbiota regulation against obesity, green tea and Pu-erh tea for metabolic syndrome, and marine-derived oligosaccharide (GV-971) from brown algae for anti-dementia. Moreover, novel TCM molecular targets and pharmacological mechanisms were trialed against different human diseases, including cancers, cardiovascular, cerebrovascular diseases, diabetes, and metabolic diseases. Notably, herb-derived bioactive products have become important treatment alternatives for cancer research in 2019. Cardiovascular and cerebrovascular diseases, together with diabetes and metabolic diseases, are ongoing research areas for traditional medicine. Moreover, inflammation and infectious disease are also attracting more attention by researchers, which might have been influenced by seasonal influenza or HIV/Ebola viral infections. Further traditional medicine investigations are required in neurodegenerative diseases, depression, and mental diseases. Taken together, the findings of the integrative pharmacology review in 2019 provide a vast number of novel lead compounds or drug candidates for future clinical agent development and also details a novel series of attractive therapeutic targets and molecular mechanisms for human diseases.
C1 [Zeng, Ke-Wu] Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, 38 Xueyuan Rd, Beijing 100191, Peoples R China.
   [Gu, Ming-Yao] Shenzhen Univ, Dept Cell Biol & Med Genet, Sch Basic Med Sci, Hlth Sci Ctr, Shenzhen 51801, Peoples R China.
C3 Peking University; Shenzhen University
RP Zeng, KW (corresponding author), Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, 38 Xueyuan Rd, Beijing 100191, Peoples R China.; Gu, MY (corresponding author), Shenzhen Univ, 1066 Xueyuan Ave, Shenzhen 51801, Peoples R China.
EM ZKW@bjmu.edu.cn; mingyao@szu.edu.cn
RI Ke-wu, Zeng/U-6930-2019
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NR 60
TC 0
Z9 0
U1 4
U2 38
PU TMR PUBLISHING GROUP
PI TIANJIN
PA BOLING BUILDING 902, DAZHIGU CENTER ST, TIANJIN, 00000, PEOPLES R CHINA
SN 2413-3973
J9 TRADIT MED RES
JI Tradit. Med. Res.
PD MAR 2
PY 2020
VL 5
IS 2
BP 74
EP 82
DI 10.12032/TMR20200214163
PG 9
WC Integrative & Complementary Medicine
WE Emerging Sources Citation Index (ESCI)
SC Integrative & Complementary Medicine
GA KS6ON
UT WOS:000518426600003
DA 2025-06-11
ER

PT J
AU Fernandez-Egea, E
   García-Rizo, C
   Miller, B
   Parellada, E
   Justicia, A
   Bernardo, M
   Kirkpatrick, B
AF Fernandez-Egea, Emilio
   Garcia-Rizo, Clemente
   Miller, Brian
   Parellada, Eduard
   Justicia, Azucena
   Bernardo, Miguel
   Kirkpatrick, Brian
TI Testosterone in Newly Diagnosed, Antipsychotic-Naive Men With
   Nonaffective Psychosis: A Test of the Accelerated Aging Hypothesis
SO PSYCHOSOMATIC MEDICINE
LA English
DT Article
DE schizophrenia; sex hormone; androgen; senescence; aging; first episode
ID SERUM TESTOSTERONE; NEGATIVE SYMPTOMS; CHRONIC-SCHIZOPHRENIA; METABOLIC
   SYNDROME; DISORDERS; SEVERITY; HORMONES; DIMENSIONS; PEOPLE; LEVEL
AB Objective: Schizophrenia has been associated with age-related abnormalities, including abnormal glucose tolerance, increased pulse pressure, increased inflammation, abnormal stem cell signaling, and shorter telomere length. These metabolic abnormalities and other findings suggest that schizophrenia and related disorders might be associated with accelerated aging. Testosterone activity has a progressive decline with increasing age. Methods: We tested the hypothesis that circulating biologically active testosterone is lower in newly diagnosed, antipsychotic-naive male patients with nonaffective psychosis than in matched control subjects. Results: Patients (n = 33) were matched to control subjects (n = 33) for age, sex, body mass index, socioeconomic status of the family of origin, and smoking. The free androgen index, a measure of biologically active testosterone, was significantly lower in the psychosis group (mean [standard deviation] = 57.7% [26.1]) than in control subjects (71.6% [27.0], p = .04), with an effect size of 0.53. Multivariate analysis also supported the findings. In the psychosis group, free androgen index had a significant negative correlation with the conceptual disorganization item (r = -0.35, p = .049) but not with reality distortion (r = -0.21, p = .24), negative symptoms (r = 0.004, p = .98), or depression (r = -0.014, p = .94). Conclusions: Lower testosterone level is consistent with accelerated aging in nonaffective psychosis, but further testing of this hypothesis is needed.
C1 [Fernandez-Egea, Emilio; Justicia, Azucena] Univ Cambridge, Behav & Clin Neurosci Inst, Dept Psychiat, Cambridge CB2 0QQ, England.
   [Fernandez-Egea, Emilio] Cambridgeshire & Peterborough NHS Fdn Trust, Huntingdon, England.
   [Fernandez-Egea, Emilio; Garcia-Rizo, Clemente; Parellada, Eduard; Justicia, Azucena; Bernardo, Miguel] Hosp Clin Barcelona, Inst Neurosci, Dept Psychiat, Schizophrenia Program, Barcelona, Spain.
   [Garcia-Rizo, Clemente; Parellada, Eduard; Bernardo, Miguel] Ctr Invest Biomed Red Salud Mental, Barcelona, Spain.
   [Miller, Brian] Med Coll Georgia, Dept Psychiat & Hlth Behav, Augusta, GA 30912 USA.
   [Parellada, Eduard; Bernardo, Miguel] Univ Barcelona, Inst Biomed Res Agusti Pi i Sunyer, Barcelona, Spain.
   [Parellada, Eduard; Bernardo, Miguel] Univ Barcelona, Dept Psychiat & Clin Psychobiol, Barcelona, Spain.
   [Kirkpatrick, Brian] Texas A&M Univ, Coll Med, Dept Psychiat, Temple, TX 76508 USA.
   Scott & White Healthcare, Temple, TX USA.
C3 University of Cambridge; University of Barcelona; Hospital Clinic de
   Barcelona; CIBER - Centro de Investigacion Biomedica en Red; CIBERSAM;
   University System of Georgia; Augusta University; University of
   Barcelona; Hospital Clinic de Barcelona; IDIBAPS; University of
   Barcelona; Texas A&M University System
RP Fernandez-Egea, E (corresponding author), Univ Cambridge, Addenbrookes Hosp, Dept Psychiat Level 4, Box 189, Cambridge CB2 0QQ, England.
EM ef280@cam.ac.uk
RI Parellada, Eduard/I-2675-2015; garcia-rizo, clemente/C-5520-2019;
   Bernardo, Miquel/P-3049-2015
OI Parellada, Eduard/0000-0003-1131-4980; garcia-rizo,
   clemente/0000-0002-4855-1608; Justicia, Azucena/0000-0002-5950-9528;
   Bernardo, Miquel/0000-0001-8748-6717; Fernandez-Egea,
   Emilio/0000-0003-4128-8955
FU National Institute of Diabetes and Digestive and Kidney Diseases [RO1
   DK069265]; National Alliance for Research on Schizophrenia and
   Depression; Government of Catalonia, Comissionat per Universitats I
   Recerca del Departament d'Innovacio, Universitats I Empresa
   [2009SGR1295]; Instituto de Salud Carlos III, Centro de Investigacion
   Biomedica en Red de Salud Mental; Bristol-Meyers Squibb; Janssen-Cilag;
   GlaxoSmithKline; Pfizer; Organon; AstraZeneca; Wyeth; Lilly; Cephalon;
   Solvay
FX This study is supported in part by Grant RO1 DK069265 from the National
   Institute of Diabetes and Digestive and Kidney Diseases (Dr Kirkpatrick)
   and National Alliance for Research on Schizophrenia and Depression (Dr
   Fernandez-Egea), by the Government of Catalonia, Comissionat per
   Universitats I Recerca del Departament d'Innovacio, Universitats I
   Empresa 2009SGR1295, and by the Instituto de Salud Carlos III, Centro de
   Investigacion Biomedica en Red de Salud Mental (Dr Bernardo). The views
   stated in this article represent those of the authors and are not
   official statements of the National Institute of Diabetes and Digestive
   and Kidney Diseases or the National Institutes of Health. Drs
   Fernandez-Egea, Garcia-Rizo, and Miller and Ms Justicia have no conflict
   of interest to disclose. Dr Bernardo received consultant fees from
   Bristol-Meyers Squibb and Wyeth. He also received honoraria from
   Janssen-Cilag, Eli Lilly Company, Pfizer, Synthelabo, GlaxoSmithKline,
   and AstraZeneca. Dr Parellada received research grants and consultant
   fees from Janssen-Cilag and GlaxoSmithKline and served on the
   speakers/advisory boards for Janssen-Cilag. Dr Kirkpatrick received
   consulting and/or speaking fees from Pfizer, Organon, AstraZeneca,
   Wyeth, Lilly, Bristol-Myers Squibb, Cephalon, and Solvay.
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NR 38
TC 33
Z9 35
U1 0
U2 7
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0033-3174
EI 1534-7796
J9 PSYCHOSOM MED
JI Psychosom. Med.
PD OCT
PY 2011
VL 73
IS 8
BP 643
EP 647
DI 10.1097/PSY.0b013e318230343f
PG 5
WC Psychiatry; Psychology; Psychology, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry; Psychology
GA 835QP
UT WOS:000296051200002
PM 21949421
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Ko, DH
   Lee, K
   Chung, J
AF Ko, Duk Han
   Lee, Kyujin
   Chung, Jinwook
TI EFFECTS OF LONG-TERM AND SHORT-TERM CARDIAC REHABILITATION PROGRAMS ON
   CARDIOVASCULAR RISK FACTORS AND PHYSICAL FITNESS AFTER PERCUTANEOUS
   CORONARY INTERVENTION
SO JOURNAL OF MENS HEALTH
LA English
DT Article
DE cardiac rehabilitation; risk factor; fitness; percutaneous coronary
   intervention
ID ARTERY-DISEASE; METABOLIC SYNDROME; EXERCISE; ASSOCIATION; IMPACT;
   PREDICTORS; PREVENTION; DEPRESSION; NUTRITION; MORTALITY
AB Background
   Cardiac rehabilitation programs reduce the likelihood of relapse and cardiac arrest in patients with coronary artery disease. The goal of this study was to compare and analyze changes in cardiovascular risk factors and physical fitness in patients who participated in short-term (ST) and long-term (LT) cardiac rehabilitation programs following coronary artery percutaneous coronary intervention (PCI).
   Methods
   This study included 193 men aged >= 45 years who received PCI for coronary artery occlusive disease. The participants were divided into ST program participants (3 months, 108 participants; ST group) and LT program participants (12 months, 85 participants; LT group). Blood lipids analysis, body composition, and physical fitness tests were performed to assess cardiovascular risk factors and physical fitness. Paired t-test and two-way ANOVA with repeated measures were used to investigate the effect of the intervention.
   Results
   Both groups had significant improvements after cardiac rehabilitation in body fat, high-density lipoprotein cholesterol, exercise duration, heart rate (HR) at rest, double product peak, VO2 peak, 6-min walking, and sit-to-stand, compared to baseline. The LT group also had significant improvements after cardiac rehabilitation in waist circumference (WC), total cholesterol (TC), triglyceride (TG), and HR peak. LT group had significantly improved effect than ST group in WC, TC, TG, exercise time, HR peak, and 6-min walking.
C1 [Ko, Duk Han; Chung, Jinwook] Dongguk Univ, Dept Sports Sci Convergence, Seoul, South Korea.
   [Lee, Kyujin] Seoul Natl Univ, Inst Sports Sci, Dept Phys Educ, Seoul, South Korea.
C3 Dongguk University; Seoul National University (SNU)
RP Chung, J (corresponding author), Dongguk Univ, Dept Sports Sci Convergence, Seoul, South Korea.; Lee, K (corresponding author), Seoul Natl Univ, Inst Sports Sci, Dept Phys Educ, Seoul, South Korea.
EM my993286@snu.ac.kr; cjw826@dongguk.edu
OI Lee, Kyujin/0000-0002-0245-7085; Ko, Duk han/0000-0002-8745-4851
CR Al-Daghri NM, 2014, BMC CARDIOVASC DISOR, V14, DOI [10.1186/1471-2458-14-391, 10.1186/1471-2261-14-51]
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NR 33
TC 2
Z9 2
U1 1
U2 14
PU MRE PRESS
PI SINGAPORE
PA 14 ROBINSON RD #08-01A FAR EAST FINANCE, SINGAPORE, SINGAPORE
SN 1875-6867
EI 1875-6859
J9 J MENS HEALTH
JI J. Mens Health
PY 2020
VL 16
IS 3
BP E29
EP E37
DI 10.15586/jomh.v16i3.253
PG 9
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA PH7WK
UT WOS:000600617700001
OA gold
DA 2025-06-11
ER

PT J
AU Choromanska, B
   Mysliwiec, P
   Dadan, J
   Maleckas, A
   Zalewska, A
   Maciejczyk, M
AF Choromanska, Barbara
   Mysliwiec, Piotr
   Dadan, Jacek
   Maleckas, Almantas
   Zalewska, Anna
   Maciejczyk, Mateusz
TI Effects of age and gender on the redox homeostasis of morbidly obese
   people
SO FREE RADICAL BIOLOGY AND MEDICINE
LA English
DT Article
DE Morbid obesity; Redox biomarkers; Oxidative; nitrosative stress;
   Antioxidants; Total antioxidant activity
ID GLYCATION END-PRODUCTS; OXIDATION PROTEIN PRODUCTS; TOTAL ANTIOXIDANT
   CAPACITY; NITRIC-OXIDE SYNTHASE; NECROSIS-FACTOR-ALPHA;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; S-NITROSOTHIOLS; STRESS MARKERS;
   PLASMA
AB Obesity is a chronic disease of complex etiology. Recent evidence suggests that obesity is caused by inflammation of adipose tissue leading to metabolic disorders, cardiovascular disease and cancer. This is the first study to evaluated the effects of age and gender on redox homeostasis, glutathione metabolism, and oxidative damage to plasma/serum lipids and proteins in morbidly obese patients. The study included 120 (60 men and 60 women) morbidly obese patients with class 3 obesity (BMI > 40 kg/m2), classified into three groups depending on age: 20-39 years (n = 20), 40-59 years (n = 20) and 60 years or older (n = 20). The number of patients was calculated a priori based on our previous experiment. We observed a reduction in serum activity of antioxidant enzymes (down arrow SOD) and plasma concentration of non-enzymatic antioxidants (down arrow GSH) in obese patients compared to the lean controls, which further decreased with age. Redox status (up arrow TAC, up arrow TOS and down arrow OSI) in morbidly obese men and women was shifted towards oxidation. Moreover, lipid (up arrow MDA and up arrow LOOH) and protein (up arrow AOPP, up arrow AGE and up arrow Amadori products) damage products of oxidation and nitrosylation/nitration (up arrow total NO, up arrow S-nitrosothiols, up arrow peroxynitrite and up arrow nitrotyrosine) were elevated in both genders of morbidly obese patients and were higher in the elderly. Interestingly, the concentrations of oxidative and nitrosative stress markers were generally higher in obese men compared to obese women at the same age. Summarizing, we showed that the total antioxidant/ oxidant potential of obese patients is significantly increased and shifted towards oxidation. Obese patients have increased lipid and protein oxidation, glycation and nitration as compared to the lean controls. Disturbances in redox homeostasis increase with age in obese patients. Oxidative and nitrosative stress are more intense in men than in women at the same age.
C1 [Choromanska, Barbara; Mysliwiec, Piotr; Dadan, Jacek] Med Univ Bialystok, Dept Gen & Endocrine Surg 1, 24a M Sklodowskiej Curie St, PL-15276 Bialystok, Poland.
   [Maleckas, Almantas] Lithuanian Univ Hlth Sci, Dept Surg, Kaunas, Lithuania.
   [Maleckas, Almantas] Univ Gothenburg, Sahlgrenska Acad, Dept Gastrosurg Res & Educ, Gothenburg, Sweden.
   [Zalewska, Anna] Med Univ Bialystok, Expt Dent Lab, 24a M Sklodowskiej Curie St, PL-15274 Bialystok, Poland.
   [Maciejczyk, Mateusz] Med Univ Bialystok, Dept Hyg Epidemiol & Ergon, 2c Mickiewicza St, PL-15233 Bialystok, Poland.
C3 Medical University of Bialystok; Lithuanian University of Health
   Sciences; University of Gothenburg; Medical University of Bialystok;
   Medical University of Bialystok
RP Maciejczyk, M (corresponding author), Med Univ Bialystok, Dept Hyg Epidemiol & Ergon, 2c Mickiewicza St, PL-15233 Bialystok, Poland.
EM barbara.choromanska@umb.edu.pl; piotr.a.mysliwiec@gmail.com;
   jacdad@poczta.onet.pl; almantas.maleckas@gmail.com;
   azalewska426@gmail.com; mat.maciejczyk@gmail.com
RI Zalewska, Anna/AAG-9484-2019; Myśliwiec, Piotr/T-4220-2018; Maciejczyk,
   Mateusz/R-6568-2018
OI Maciejczyk, Mateusz/0000-0001-5609-3187
FU Medical University of Bialystok, Poland [SUB/1/DN/21/001/1140,
   SUB/1/DN/21/002/3330]; Foundation for Polish Science (FNP)
FX This work was granted by the Medical University of Bialystok, Poland
   (grant number: SUB/1/DN/21/001/1140, SUB/1/DN/21/002/3330) . Dr. Mateusz
   Maciejczyk was supported by the Foundation for Polish Science (FNP) .
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NR 89
TC 20
Z9 21
U1 0
U2 6
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0891-5849
EI 1873-4596
J9 FREE RADICAL BIO MED
JI Free Radic. Biol. Med.
PD NOV 1
PY 2021
VL 175
BP 108
EP 120
DI 10.1016/j.freeradbiomed.2021.08.009
EA SEP 2021
PG 13
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA UY7CZ
UT WOS:000701678600002
PM 34390781
OA hybrid
DA 2025-06-11
ER

PT J
AU Ekta
   Gupta, M
   Kaur, A
   Singh, TG
   Bedi, O
AF Ekta
   Gupta, Manisha
   Kaur, Amarjot
   Singh, Thakur Gurjeet
   Bedi, Onkar
TI Pathobiological and molecular connections involved in the high fructose
   and high fat diet induced diabetes associated nonalcoholic fatty liver
   disease
SO INFLAMMATION RESEARCH
LA English
DT Review
DE Diabetes mellitus; High fat high fructose; Proinflammatory mediators;
   Apolipoprotein; Diabetic liver injury; Thioredoxin 2; Metabolic
   disorders
ID ENDOPLASMIC-RETICULUM STRESS; INSULIN-RESISTANCE; GUT MICROBIOTA;
   HEPATIC STEATOSIS; METABOLIC SYNDROME; KAPPA-B; LIPOPROTEIN-LIPASE;
   OXIDATIVE STRESS; LIPID-METABOLISM; SKELETAL-MUSCLE
AB Background Poor dietary habits such as an over consumption of high fructose and high fat diet are considered as the major culprit for the induction of diabetes associated liver injury. Diabetes mellitus is a metabolic disorder that affects various vital organs of the body especially the kidney, brain, heart, and liver. The high fructose and high fat (HFHF) diet worsen the metabolic conditions by producing various pathogenic burdens such as oxidative stress, inflammation, etc. on liver. The hyperlipidemic and hyperglycemic conditions induced by HFHF diet leads to the generation of various proinflammatory mediators like TNF alpha, interleukin and cytokines. Aim and methods The systematic bibliographical literature survey was done with the help of PubMed, Google scholar and MedLine to identify all pathological and molecular concerened with HFHF induced diabetic liver injury. The consumption of HFHF diet leads to an increase in mitochondrial oxidative stress thereby decreases the liver protective antioxidants required for cell viability. HFHF diet disturbs lipid and lipoprotein clearance by elevating the level of apolipoprotein CIII and impairing the hydrolysis of triglyceride. As a result, there is an increase in free fatty acid concentration, triglycerides and diacylglycerol in the liver which further triggers the situation of insulin resistance. Conclusion The focus of present review is based upon the various pathological, genetic and molecular mechanism involved in the development of high-fat high fructose diet induced diabetic liver injury. However, the current review also documented few shreds of evidence related to various microRNAs (miR-31, miR-33a, miR-34a, miR-144, miR-146b, miR-150) concerned to HFHF diet which play an important role in the pathogenesis of diabetes associated liver injury Dietary life style modification may prove beneficial in the management of various metabolic disorders.
C1 [Ekta; Gupta, Manisha; Kaur, Amarjot; Singh, Thakur Gurjeet; Bedi, Onkar] Chitkara Univ, Chitkara Coll Pharm, Rajpura, Punjab, India.
C3 Chitkara University, Punjab
RP Bedi, O (corresponding author), Chitkara Univ, Chitkara Coll Pharm, Rajpura, Punjab, India.
EM onkar.bedi@chitkara.edu.in
RI grewal, amarjot/HLQ-4585-2023; Bedi, Onkar/AAZ-5394-2020; Singh, Dr.
   Thakur Gurjeet/AGV-7671-2022
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   Gurjeet/0000-0003-2979-1590
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NR 169
TC 17
Z9 18
U1 5
U2 44
PU SPRINGER BASEL AG
PI BASEL
PA PICASSOPLATZ 4, BASEL, 4052, SWITZERLAND
SN 1023-3830
EI 1420-908X
J9 INFLAMM RES
JI Inflamm. Res.
PD SEP
PY 2020
VL 69
IS 9
BP 851
EP 867
DI 10.1007/s00011-020-01373-7
EA JUN 2020
PG 17
WC Cell Biology; Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Immunology
GA MT1ND
UT WOS:000542512500001
PM 32577775
DA 2025-06-11
ER

PT J
AU Ge, CX
   Xu, MX
   Qin, YT
   Gu, TT
   Feng, J
   Lv, JX
   Wang, SJ
   Ma, YJ
   Lou, DS
   Li, Q
   Hu, LF
   Nie, XY
   Wang, MX
   Huang, P
   Tan, J
AF Ge Chenxu
   Xu Minxuan
   Qin Yuting
   Gu Tingting
   Feng Jing
   Lv Jinxiao
   Wang Sujun
   Ma Yongjie
   Lou Deshuai
   Li Qiang
   Hu Linfeng
   Nie Xuyuan
   Wang Mingxing
   Huang Ping
   Tan Jun
TI Loss of RIP3 initiates annihilation of high-fat diet initialized
   nonalcoholic hepatosteatosis: A mechanism involving Toll-like receptor 4
   and oxidative stress
SO FREE RADICAL BIOLOGY AND MEDICINE
LA English
DT Article
DE NAFLD; RIP3; Inflammation and oxidative stress; TLR-4/NF-kappa B;
   Nrf-2/HO-1
ID ISCHEMIA-REPERFUSION INJURY; LIVER-DISEASE; CELL-DEATH; TNF-ALPHA;
   INSULIN-RESISTANCE; HEPATIC STEATOSIS; MITOCHONDRIAL ROS; ACTIVATION;
   NECROSIS; NAFLD
AB Non-alcoholic fatty liver disease (NAFLD) is a prevalent and complex disease that confers a high risk of severe liver disorders. Although such public and clinical health importance, very few effective therapies are presently available for NAFLD. Here, we showed that receptor-interacting kinase-3 (RIP3) was up-regulated in liver of mouse with hepatic steatosis induced by high fat diet (HFD). After 16 weeks on a HFD, obesity, insulin resistance, metabolic syndrome, hepatic steatosis, inflammatory response and oxidative stress were significantly alleviated in liver of mice with the loss of RIP3. We provided mechanistic evidence that RIP3 knockdown attenuated hepatic dyslipidemia through preventing the expression of lipogenesis-associated genes. Furthermore, in the absence of RIP3, the transcription factor of nuclear factor-kappa B (NF-kappa B) signaling pathway activated by HFD was blocked, accompanied with the inhibition of NLRP3 inflammasome. We also found that RIP3 knockdown-induced activation of nuclear factor-erythroid 2 related factor 2/heme oxygenase-1 (Nrf-2/HO-1) led to the inhibition of oxidative stress. The detrimental effects of RIP3 on hepatic steatosis and related pathologies were confirmed in palmitate (PAL)-treated mouse liver cells. Of note, lipopolysaccharide (LPS)-or PAL-activated TLR4 resulted in the up-regulation of RIP3 that was accompanied by the elevated inflammation and lipid deposition, and these effects were reversed in TLR-4 knockdown cells. Furthermore, promoting Nrf-2 pathway activation effectively reduced reactive oxygen species (ROS) generation and RIP3 expression in PAL-stimulated cells, consequently leading to the suppression of cellular inflammation and lipid accumulation. In contrast, blocking Nrf-2/HO-1 signaling abrogated RIP3 knockdown-reduced reactive oxygen species (ROS), inflammatory response and lipid deposition in PAL-stimulated cells. Taken together, the present study helped to elucidate how HFD-induced hepatic steatosis was regulated by RIP3, via the TLR-4/ NF-kappa B and Nrf-2/ HO-1 signaling pathways.
C1 [Ge Chenxu; Xu Minxuan; Feng Jing; Lou Deshuai; Li Qiang; Hu Linfeng; Nie Xuyuan; Tan Jun] Chongqing Univ Educ, Sch Biol & Chem Engn, Chongqing Key Lab Med Resources Three Gorges Rese, Chongqing 400067, Peoples R China.
   [Qin Yuting; Lv Jinxiao] Ocean Univ China, Sch Med & Pharm, Qingdao 266100, Shandong, Peoples R China.
   [Ge Chenxu; Xu Minxuan; Lou Deshuai; Li Qiang; Hu Linfeng; Nie Xuyuan; Tan Jun] Chongqing Univ Educ, Res Ctr Brain Intellectual Promot & Dev Children, Chongqing 400067, Peoples R China.
   [Gu Tingting] Nanjing Univ, Coll Engn & Appl Sci, Nanjing 210023, Jiangsu, Peoples R China.
   [Wang Sujun; Ma Yongjie; Wang Mingxing] Luoyang Normal Univ, Coll Food & Drug, Luoyang 471934, Peoples R China.
   [Huang Ping] Chongqing Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Chongqing 400000, Peoples R China.
C3 Chongqing University of Education; Ocean University of China; Chongqing
   University of Education; Nanjing University; Luoyang Normal University;
   Chongqing Medical University
RP Xu, MX; Tan, J (corresponding author), Chongqing Univ Educ, Sch Biol & Chem Engn, Chongqing Key Lab Med Resources Three Gorges Rese, Chongqing 400067, Peoples R China.
EM minxuanxu@foxmail.com; tanjun@cque.edu.cn
RI hu, linfeng/C-6491-2014
FU National Natural Science Foundation of China (NSFC) [81703527];
   Chongqing Research Program of Basic Research and Frontier Technology
   [cstc2017jcyjAX0356, cstc2018jcyjA3686, cstc2018jcyjA1472,
   cstc2018jcyjA3533]; 2018 Chongqing College Students' Innovation and
   Entrepreneurship Training Project [201814388021, 201814388022];
   School-level Research Program of Chongqing University of Education
   [KY201710B, 17GZKP01]; Advanced Programs of Post-doctor of Chongqing
   [2017LY39]
FX This work was supported by National Natural Science Foundation of China
   (NSFC Grant no.: 81703527); Chongqing Research Program of Basic Research
   and Frontier Technology (Grant nos.: cstc2017jcyjAX0356,
   cstc2018jcyjA3686, cstc2018jcyjA1472 and cstc2018jcyjA3533); 2018
   Chongqing College Students' Innovation and Entrepreneurship Training
   Project (Grant nos.: 201814388021 and 201814388022); School-level
   Research Program of Chongqing University of Education (Grant nos.:
   KY201710B and 17GZKP01); Advanced Programs of Post-doctor of Chongqing
   (Grant no.: 2017LY39).
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NR 84
TC 51
Z9 55
U1 0
U2 22
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0891-5849
EI 1873-4596
J9 FREE RADICAL BIO MED
JI Free Radic. Biol. Med.
PD APR
PY 2019
VL 134
BP 23
EP 41
DI 10.1016/j.freeradbiomed.2018.12.034
PG 19
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA ID6WQ
UT WOS:000471822700003
PM 30599260
DA 2025-06-11
ER

PT J
AU Kubota, M
   Shimizu, M
   Sakai, H
   Yasuda, Y
   Ohno, T
   Kochi, T
   Tsurumi, H
   Tanaka, T
   Moriwaki, H
AF Kubota, Masaya
   Shimizu, Masahito
   Sakai, Hiroyasu
   Yasuda, Yoichi
   Ohno, Tomohiko
   Kochi, Takahiro
   Tsurumi, Hisashi
   Tanaka, Takuji
   Moriwaki, Hisataka
TI Renin-angiotensin system inhibitors suppress azoxymethane-induced
   colonic preneoplastic lesions in C57BL/KsJ-db/db obese
   mice
SO BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
LA English
DT Article
DE Obesity; Colorectal cancer; Chemoprevention; Renin-angiotensin system;
   Inflammation; Oxidative stress
ID NECROSIS-FACTOR-ALPHA; COLORECTAL-CANCER; PREMALIGNANT LESIONS;
   METABOLIC SYNDROME; RECEPTOR BLOCKERS; OXIDATIVE STRESS; ACE-INHIBITORS;
   MOUSE MODEL; RISK; CARCINOGENESIS
AB Obesity-related metabolic abnormalities, including chronic inflammation and oxidative stress, increase the risk of colorectal cancer. Dysregulation of the renin-angiotensin system (RAS) also plays a critical role in obesity-related metabolic disorders and in several types of carcinogenesis. In the present study, we examined the effects of an angiotensin-converting enzyme (ACE) inhibitor and angiotensin-II type 1 receptor blocker (ARB), both of which inhibit the RAS, on the development of azoxymethane (AOM)-initiated colonic premalignant lesions in C57BL/KsJ-db/db (db/db) obese mice. Male db/db mice were given 4 weekly subcutaneous injections of AOM (15 mg/kg body weight), and then, they received drinking water containing captopril (ACE inhibitor, 5 mg/kg/day) or telmisartan (ARB, 5 mg/kg/day) for 7 weeks. At sacrifice, administration of either captopril or telmisartan significantly reduced the total number of colonic premalignant lesions, i.e., aberrant crypt foci and beta-catenin accumulated crypts, compared to that observed in the control group. The expression levels of TNF-alpha mRNA in the colonic mucosa of AOM-treated db/db mice were decreased by captopril and telmisartan. Captopril lowered the expression levels of TNF-alpha, IL-1 beta, IL-6, and PAI-1 mRNAs, while telmisartan lowered the expression levels of COX-2, IL-1 beta, IL-6, and PAI-1 mRNAs in the white adipose tissues of these mice. In addition, these agents significantly reduced the levels of urinary 8-OHdG, a surrogate marker of oxidative damage to DNA, in the experimental mice. These findings suggested that both ACE inhibitor and ARB suppress chemically-induced colon carcinogenesis by attenuating chronic inflammation and reducing oxidative stress in obese mice. Therefore, targeting dysregulation of the RAS might be an effective strategy for chemoprevention of colorectal carcinogenesis in obese individuals. (C) 2011 Elsevier Inc. All rights reserved.
C1 [Kubota, Masaya; Shimizu, Masahito; Sakai, Hiroyasu; Yasuda, Yoichi; Ohno, Tomohiko; Kochi, Takahiro; Tsurumi, Hisashi; Moriwaki, Hisataka] Gifu Univ, Grad Sch Med, Dept Internal Med, Gifu 5011194, Japan.
   [Tanaka, Takuji] Tohkai Cytopathol Inst, Gifu, Japan.
C3 Gifu University
RP Shimizu, M (corresponding author), Gifu Univ, Grad Sch Med, Dept Internal Med, 1-1 Yanagido, Gifu 5011194, Japan.
EM shimim-gif@umin.ac.jp
FU Ministry of Education, Science, Sports and Culture of Japan [22790638,
   21590838]; Ministry of Health, Labor and Welfare of Japan; Grants-in-Aid
   for Scientific Research [21590838] Funding Source: KAKEN
FX This work was supported in part by Grants-in-Aid from the Ministry of
   Education, Science, Sports and Culture of Japan (No. 22790638 to M.S.
   and No. 21590838 to H.M.) and by a Grant-in-Aid for the 3rd Term
   Comprehensive 10-Year Strategy for Cancer Control from the Ministry of
   Health, Labor and Welfare of Japan.
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NR 42
TC 38
Z9 39
U1 0
U2 8
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0006-291X
EI 1090-2104
J9 BIOCHEM BIOPH RES CO
JI Biochem. Biophys. Res. Commun.
PD JUN 24
PY 2011
VL 410
IS 1
BP 108
EP 113
DI 10.1016/j.bbrc.2011.05.115
PG 6
WC Biochemistry & Molecular Biology; Biophysics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics
GA 788HG
UT WOS:000292435400020
PM 21640075
DA 2025-06-11
ER

PT J
AU Zhao, JW
   Cai, XT
   Hu, JL
   Song, SW
   Zhu, Q
   Shen, D
   Yang, WB
   Luo, Q
   Yao, XG
   Zhang, DL
   Hong, J
   Li, NF
AF Zhao, Jianwen
   Cai, Xintian
   Hu, Junli
   Song, Shuaiwei
   Zhu, Qing
   Shen, Di
   Yang, Wenbo
   Luo, Qin
   Yao, Xiaoguang
   Zhang, Delian
   Hong, Jing
   Li, Nanfang
TI J-Shaped Relationship Between Weight-AdjustedWaist Index and
   Cardiovascular Disease Risk in Hypertensive Patients with Obstructive
   Sleep Apnea: A Cohort Study
SO DIABETES METABOLIC SYNDROME AND OBESITY
LA English
DT Article
DE hypertensive; obstructive sleep apnea; weight-adjusted-waist index;
   cardiovascular disease; visceral obesity
ID BODY-MASS INDEX; VISCERAL ADIPOSITY INDEX; TO-HEIGHT RATIO; WAIST
   CIRCUMFERENCE; CARDIOMETABOLIC RISK; FAT DISTRIBUTION; OXIDATIVE STRESS;
   OBESITY PARADOX; BMI; ASSOCIATION
AB Background: A newly introduced obesity-related index, the weight-adjusted-waist index (WWI), emerges as a promising predictor of cardiovascular disease (CVD). Given the known synergistic effects of hypertension and obstructive sleep apnea (OSA) on cardiovascular risk, we aimed to explore the relationship between the WWI and CVD risk specifically within this high-risk cohort. Methods: A total of 2265 participants with hypertension and OSA were included in the study. Multivariate Cox regression analysis was used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) for CVD events. The restricted cubic spline (RCS) was used to further evaluate the nonlinear dose-response relationship. Results: During a median follow-up period of 6.8 years, 324 participants experienced a CVD event. Multivariate Cox regression analysis revealed that compared to the reference group, the HRs for the second, third, and fourth groups were 1.12 (95% CI, 0.79- 1.59), 1.35 (95% CI, 0.96-1.89), and 1.58 (95% CI, 1.13-2.22), respectively. Moreover, RCS analysis illustrated a clear J-shaped relationship between the WWI and CVD risk, particularly notable when WWI exceeded 11.5 cm/ kg, signifying a significant increase in CVD risk. Conclusion: There was a J-shaped relationship between WWI and CVD in hypertensive patients with OSA, especially when the WWI was greater than 11.5 cm/ kg, the risk of CVD was significantly increased.
C1 [Zhao, Jianwen; Cai, Xintian; Hu, Junli; Song, Shuaiwei; Zhu, Qing; Shen, Di; Yang, Wenbo; Luo, Qin; Yao, Xiaoguang; Zhang, Delian; Hong, Jing; Li, Nanfang] Peoples Hosp Xinjiang Uygur Autonomous Reg, Hypertens Ctr, 91 Tianchi Rd, Urumqi 830001, Xinjiang, Peoples R China.
   [Zhao, Jianwen; Cai, Xintian; Hu, Junli; Song, Shuaiwei; Zhu, Qing; Shen, Di; Yang, Wenbo; Luo, Qin; Yao, Xiaoguang; Zhang, Delian; Hong, Jing; Li, Nanfang] Xinjiang Hypertens Inst, Urumqi 830001, Xinjiang, Peoples R China.
   [Zhao, Jianwen; Cai, Xintian; Hu, Junli; Song, Shuaiwei; Zhu, Qing; Shen, Di; Yang, Wenbo; Luo, Qin; Yao, Xiaoguang; Zhang, Delian; Hong, Jing; Li, Nanfang] NHC Key Lab Hypertens Clin Res, Urumqi 830001, Xinjiang, Peoples R China.
   [Zhao, Jianwen; Cai, Xintian; Hu, Junli; Song, Shuaiwei; Zhu, Qing; Shen, Di; Yang, Wenbo; Luo, Qin; Yao, Xiaoguang; Zhang, Delian; Hong, Jing; Li, Nanfang] Key Lab Xinjiang Uygur Autonomous Reg, Hypertens Res Lab, Urumqi 830001, Xinjiang, Peoples R China.
   [Zhao, Jianwen; Cai, Xintian; Hu, Junli; Song, Shuaiwei; Zhu, Qing; Shen, Di; Yang, Wenbo; Luo, Qin; Yao, Xiaoguang; Zhang, Delian; Hong, Jing; Li, Nanfang] Xinjiang Clin Med Res Ctr Hypertens Cardio Cerebro, Urumqi 830001, Xinjiang, Peoples R China.
RP Li, NF (corresponding author), Peoples Hosp Xinjiang Uygur Autonomous Reg, Hypertens Ctr, 91 Tianchi Rd, Urumqi 830001, Xinjiang, Peoples R China.
EM lnanfang2016@sina.com
RI 周, 丽敏/JEO-3613-2023; Yang, Wenbo/NJR-4372-2025; Luo, Qin/KDM-6812-2024;
   Song, Shuaiwei/HPH-0267-2023
OI Cai, Xintian/0000-0003-3172-1540; Song, Shuaiwei/0009-0007-2444-2136;
   Li, Nanfang/0000-0003-1505-8566; Shen, Di/0009-0005-3689-7475
FU Tianshan Talent Training Program -Science and Technology Innovation Team
   [2023TSYCTD0016]; People's Hospital of Xinjiang Uygur Autonomous Region
   [20220111]
FX Funding This study was funded by the Tianshan Talent Training Program
   -Science and Technology Innovation Team (No. 2023TSYCTD0016) and the
   People's Hospital of Xinjiang Uygur Autonomous Region (No. 20220111) .
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NR 51
TC 29
Z9 29
U1 7
U2 15
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-7007
J9 DIABET METAB SYND OB
JI Diabetes Metab. Syndr. Obes.
PY 2024
VL 17
BP 2671
EP 2681
DI 10.2147/DMSO.S469376
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA XK8K5
UT WOS:001261667700001
PM 38978818
OA gold
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Gioxari, A
   Amerikanou, C
   Peraki, S
   Kaliora, AC
   Skouroliakou, M
AF Gioxari, Aristea
   Amerikanou, Charalampia
   Peraki, Sevasti
   Kaliora, Andriana C.
   Skouroliakou, Maria
TI Eating Behavior and Factors of Metabolic Health in Primary
   Schoolchildren: A Cross-Sectional Study in Greek Children
SO NUTRIENTS
LA English
DT Article
DE primary school children; breakfast at home; metabolic health;
   cardiorespiratory fitness; handgrip strength; antioxidant status
ID VITAMIN-E TREATMENT; BODY-MASS INDEX; TO-HEIGHT RATIO; CARDIOMETABOLIC
   RISK; OXIDATIVE STRESS; OBESE CHILDREN; OVERWEIGHT; WEIGHT; ASSOCIATION;
   GENDER
AB Childhood obesity has been associated with altered blood lipids and bad eating habits. In this cross-sectional study, we assessed cardiorespiratory fitness and metabolic health markers in regard to weight status and dietary habits in schoolchildren. In 134 children (6-11 years), we conducted: (1) Anthropometry, namely z-score BMI (z-BMI), waist-to-height ratio (WHtR), and body composition analysis. (2) Measurements of handgrip strength (HGS), resting metabolic rate (RMR) and VO(2)max. (3) Quantification of blood lipids and antioxidant vitamins A, E, C. (4) Eating breakfast assessment. About 35% of children were overweight/obese. The z-BMI positively correlated with WHtR (r = 0.637, p < 0.001), and adversely correlated with fat-free mass (r = -0.728, p < 0.001) and vitamin E (r = -0.286, p < 0.001). RMR and VO(2)max were greater in normal weight children compared to those with overweight/obesity (p < 0.001). HGS did not differ between these groups, but was negatively correlated with dyslipidemia as shown by TG/HDL-C ratio (r = -0.224, p = 0.037). According to regression analysis, eating breakfast routinely at home was positively associated with RMR and adversely associated with z-BMI. Hence, regular breakfast consumption at home may improve RMR in kids. Cardiorespiratory fitness and physical strength are key modulators of metabolic health in Greek children added to a social determinant of health i.e., eating breakfast at home.
C1 [Gioxari, Aristea; Peraki, Sevasti] Univ Peloponnese, Sch Hlth Sci, Dept Nutr Sci & Dietet, Antikalamos 24100, Kalamata Messin, Greece.
   [Amerikanou, Charalampia; Kaliora, Andriana C.; Skouroliakou, Maria] Harokopio Univ, Sch Hlth Sci & Educ, Dept Dietet & Nutr Sci, 70 El Venizelou Ave, Athens 17671, Greece.
C3 Harokopio University Athens
RP Kaliora, AC (corresponding author), Harokopio Univ, Sch Hlth Sci & Educ, Dept Dietet & Nutr Sci, 70 El Venizelou Ave, Athens 17671, Greece.
EM a.gioxari@uop.gr; amerikanou@windowslive.com; nds19117@go.uop.gr;
   akaliora@hua.gr; mskour@hua.gr
RI Skouroliakou, Maria/AAN-3002-2021; Kaliora, Andriana/AAM-2912-2021;
   Gioxari, Aristea/AAA-1163-2021; Amerikanou, Charalampia/ABE-1634-2022
OI AMERIKANOU, CHARALAMPIA/0000-0002-2014-5392; Gioxari,
   Aristea/0000-0002-4869-6815; Skouroliakou, Maria/0000-0002-0468-8397
FU The authors would like to express their gratitude to all volunteers who
   participated in the study.
FX The authors would like to express their gratitude to all volunteers who
   participated in the study.
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NR 62
TC 4
Z9 4
U1 1
U2 7
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD AUG
PY 2023
VL 15
IS 16
AR 3592
DI 10.3390/nu15163592
PG 16
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA Q1WQ0
UT WOS:001055495300001
PM 37630782
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Sala, R
   Malacarne, M
   Solaro, N
   Pagani, M
   Lucini, D
AF Sala, Roberto
   Malacarne, Mara
   Solaro, Nadia
   Pagani, Massimo
   Lucini, Daniela
TI A composite autonomic index as unitary metric for heart rate
   variability: a proof of concept
SO EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
LA English
DT Article
DE Autonomic nervous system; BMI; cardiometabolic risk; hypertension;
   personal prevention; smoke
ID SYMPATHETIC-NERVE ACTIVITY; SPECTRAL-ANALYSIS; BAROREFLEX SENSITIVITY;
   STRESS; DYSFUNCTION; MORTALITY; INSIGHTS; TOOL
AB Background This study addresses whether a unitary cardiac autonomic nervous system index (ANSI), obtained combining multiple metrics from heart rate variability (HRV) into a radar plot could provide an easy appreciation of autonomic performance in a clinical setting.
   Materials and Methods Data are standardized using percentile ranking of autonomic proxies from a relatively large reference population (n = 1593, age 39 13 years). Autonomic indices are obtained from autoregressive spectral analysis of (ECG derived) HRV at rest and during standing up. A reduced ANSI (using RR, RR variance and rest-stand difference of LFnu) is then constructed as a radar plot, quantified according to its combined area and tested against different risk subgroups.
   Results With growing risk profile, there is a marked reduction of the rank value of ANSI, quantified individually by the radar plot area. The practical usefulness of the approach was tested in small groups of additional subjects putatively characterized by elevated or poor autonomic performance. Data show that elite endurance athletes are characterized by elevated values of ANSI (80.6 +/- 14.9, P < 0.001) while subjects with either Type 1 or Type 2 diabetes show lower values (DM1 = 37.0 +/- 18.9 and DM2 = 26.8 +/- 23.3, P = 0.002), and patients with coronary artery disease (CAD) represent a nadir (17 +/- 20, P < 0.001).
   Conclusions This observational study shows the feasibility of testing simpler metrics of cardiac autonomic regulation based on a multivariate unitary index in a preventive setting. This simple approach might foster a wider application of HRV in the clinical arena, and permit an easier appreciation of autonomic performance.
C1 [Sala, Roberto; Malacarne, Mara; Pagani, Massimo; Lucini, Daniela] Univ Milan, BIOMETRA Dept, Milan, Italy.
   [Sala, Roberto; Malacarne, Mara; Lucini, Daniela] Humanitas Clin & Res Hosp, Exercise Med Unit, Rozzano, Italy.
   [Solaro, Nadia] Univ Milano Bicocca, Dept Stat & Quantitat Methods, Milan, Italy.
C3 University of Milan; IRCCS Humanitas Research Hospital; University of
   Milano-Bicocca
RP Lucini, D (corresponding author), Humanitas Clin & Res Hosp, Exercise Med Unit, Via Alessandro Manzoni 56, I-20089 Milan, Italy.
EM daniela.lucini@unimi.it
RI ; Lucini, Daniela/ABD-7517-2021
OI SOLARO, NADIA/0000-0001-8732-5737; Lucini, Daniela/0000-0003-4845-8988
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NR 39
TC 27
Z9 28
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0014-2972
EI 1365-2362
J9 EUR J CLIN INVEST
JI Eur. J. Clin. Invest.
PD MAR
PY 2017
VL 47
IS 3
BP 241
EP 249
DI 10.1111/eci.12730
PG 9
WC Medicine, General & Internal; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Research & Experimental Medicine
GA EM0MC
UT WOS:000395011400005
PM 28102898
DA 2025-06-11
ER

PT J
AU Habbout, A
   Li, N
   Rochette, L
   Vergely, C
AF Habbout, Ahmed
   Li, Na
   Rochette, Luc
   Vergely, Catherine
TI Postnatal Overfeeding in Rodents by Litter Size Reduction Induces Major
   Short- and Long-Term Pathophysiological Consequences
SO JOURNAL OF NUTRITION
LA English
DT Review
ID HYPOTHALAMIC ARCUATE NEURONS; DIET-INDUCED OBESITY; NEUROPEPTIDE-Y;
   GLUCOCORTICOID METABOLISM; CARDIOVASCULAR RISK; EARLY OVERNUTRITION;
   INSULIN-SECRETION; DIABETES-MELLITUS; LEPTIN RECEPTOR; GENE-EXPRESSION
AB Numerous studies have demonstrated that the early postnatal environment can influence body weight and energy homeostasis into adulthood. Rodents raised in small litters have been shown to be a useful experimental model to study the short- and long-term consequences of early overnutrition, which can lead to modifications not only in body weight but also of several metabolic features. Postnatal overfeeding (PNOF) induces early malprogramming of the hypothalamic system, inducing acquired persisting central leptin and insulin resistance and an increase in orexigenic signals. Visceral white adipose tissue, lipogenic activity, and inflammatory status are increased in PNOF rodents, while brown adipose tissue shows reduced thermogenic activity Pancreatic and hepatic glucose responsiveness is persistently reduced in PNOF rodents, which also frequently present disturbances in plasma lipids. PNOF rodents present increased circulating concentrations of leptin, elevated corticosterone secretion, and significant changes in glucocorticoid sensitivity. PNOF also influences nephrogenesis and renal maturation. Increased oxidative stress is also described in circulating blood and in some tissues, such as the heart or liver. At the cardiovascular level, a moderate increase in arterial blood pressure is sometimes observed and rapid cardiac hypertrophy is observed at weaning; however, during maturation, impaired contractility and fibrosis are observed. Myocardial genome expression is rapidly modified in overfed mice. Moreover, hearts of PNOF rodents are more sensitive to ischemia-reperfusion injury. Together, these results suggest that the nutritional state in the immediate postnatal period should be taken into account, because it may have an impact on cardiometabolic risk in adulthood. J. Nutr. 143: 553-562, 2013.
C1 [Vergely, Catherine] Univ Burgundy, Inserm UMR866, LPPCM, Fac Med, Dijon, France.
   Univ Burgundy, Fac Pharm, Dijon, France.
C3 Universite Bourgogne Europe; Institut National de la Sante et de la
   Recherche Medicale (Inserm); Institut Agro; AgroSup Dijon; Universite
   Bourgogne Europe
RP Vergely, C (corresponding author), Univ Burgundy, Inserm UMR866, LPPCM, Fac Med, Dijon, France.
EM cvergely@u-bourgogne.fr
RI VERGELY, CATHERINE/L-9534-2015
OI VERGELY, CATHERINE/0000-0003-4009-776X; Rochette,
   Luc/0000-0001-9973-8803
FU French Ministry of Research; Institut National de la Sante et de la
   Recherche Medicale; Regional Council of Burgundy
FX Supported by grants from the French Ministry of Research, from the
   Institut National de la Sante et de la Recherche Medicale and from the
   Regional Council of Burgundy.
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NR 77
TC 111
Z9 123
U1 0
U2 22
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0022-3166
EI 1541-6100
J9 J NUTR
JI J. Nutr.
PD MAY
PY 2013
VL 143
IS 5
BP 553
EP 562
DI 10.3945/jn.112.172825
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 132GU
UT WOS:000318056700001
PM 23446961
OA Bronze, Green Submitted
DA 2025-06-11
ER

PT J
AU Gorska-Ciebiada, M
   Ciebiada, M
AF Gorska-Ciebiada, Malgorzata
   Ciebiada, Maciej
TI Adiponectin and Inflammatory Marker Levels in the Elderly Patients with
   Diabetes, Mild Cognitive Impairment and Depressive Symptoms
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE adiponectin; hs-CRP; TNF-alpha; mild cognitive impairment; depressive
   symptoms; elderly; type 2 diabetes
ID METABOLIC SYNDROME; MCI; LIFE; MOCA
AB Some studies suggest that low-grade inflammation and adipokines may be involved in mild cognitive impairment (MCI) and depression in subjects with type 2 diabetes; however, the available data concerning the elderly population are limited. Therefore, we conducted novel research to determine the serum adiponectin, hs-CRP and TNF-alpha levels in elderly diabetic patients with MCI and depressive symptoms and to identify the factors associated with MCI in this group. A total of 178 diabetic patients (mean age 84.4 +/- 3.4 years) were screened for MCI and depressive symptoms. Various biochemical and biomarker data were collected. We found that patients with MCI and depressive symptoms demonstrated lower adiponectin levels and high hs-CRP and TNF-alpha. In this group, adiponectin concentration was negatively correlated with hs-CRP, TNF-alpha, HbA1c, and GDS-30 scores and positively correlated with MoCA scores. Multivariable analysis found the risk of MCI to be associated with higher TNF-alpha levels, fewer years of formal education, an increased number of comorbidities, and the presence of CVD. We concluded that low-grade inflammation and the presence of adipokines are associated with MCI and depressive symptoms in elderly diabetics. Further research should evaluate the suitability of Hs-CRP, TNF-alpha, and adiponectin as diagnostic markers for MCI and potential therapeutic targets.
C1 [Gorska-Ciebiada, Malgorzata] Med Univ Lodz, Dept Propaedeut Lifestyle Dis, PL-90251 Lodz, Poland.
   [Ciebiada, Maciej] Med Univ Lodz, Dept Gen & Oncol Pneumol, Lodz, Poland.
C3 Medical University Lodz; Medical University Lodz
RP Gorska-Ciebiada, M (corresponding author), Med Univ Lodz, Dept Propaedeut Lifestyle Dis, PL-90251 Lodz, Poland.
EM malgorzata.gorska-ciebiada@umed.lodz.pl; maciej.ciebiada@umed.lodz.pl
RI Ciebiada, Maciej/S-9324-2016; Gorska-Ciebiada, Malgorzata/S-9668-2016
OI Gorska-Ciebiada, Malgorzata/0000-0002-0065-4376
FU Medical University of Lodz;  [503/8-072-04/503-81-001]
FX This research was funded by the Medical University of Lodz grant number
   [503/8-072-04/503-81-001] and the APC was funded by the Medical
   University of Lodz grant number [503/8-072-04/503-81-001].
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NR 45
TC 0
Z9 0
U1 0
U2 0
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD OCT
PY 2024
VL 25
IS 19
AR 10804
DI 10.3390/ijms251910804
PG 16
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA I7Z4I
UT WOS:001332399500001
PM 39409133
OA gold
DA 2025-06-11
ER

PT J
AU Kwak, PP
   Ibarra, C
   Hernandez, A
   Carrasco, J
   Sears, DD
   Jeste, D
   Marquine, MJ
   Lee, EE
AF Kwak, Paulyn P.
   Ibarra, Cynthia
   Hernandez, Alexa
   Carrasco, Jessica
   Sears, Dorothy D.
   Jeste, Dilip
   Marquine, Maria J.
   Lee, Ellen E.
TI Differences in metabolic biomarkers in people with schizophrenia who are
   of Mexican descent compared to non-Hispanic whites
SO PSYCHIATRY RESEARCH
LA English
DT Article
DE Leptin; Insulin resistance; Hispanic; Psychosis; Metabolic syndrome;
   Hemoglobin A1c
ID 3RD NATIONAL-HEALTH; BETA-CELL FUNCTION; INSULIN-RESISTANCE;
   UNITED-STATES; DIVERSE BACKGROUNDS; ETHNIC-DIFFERENCES; NEGATIVE
   SYMPTOMS; PLASMA-PROTEIN; LEPTIN LEVELS; DOUBLE-BLIND
AB Metabolic dysfunction is highly prevalent and contributes to premature mortality among people with schizophrenia (PwS), especially in Hispanic/Latino/a/x/e PwS, compared to non-Hispanic White (NHW) PwS. This study evaluated the relative contributions of Mexican descent and schizophrenia diagnosis to metabolic biomarker levels. This cross-sectional study included 115 PwS and 102 non-psychiatric comparison (NC) participants - English-speakers aged 26-66 years, 27% Mexican descent, and 52% women across both groups. Assessments included evaluations of BMI, psychopathology, and fasting metabolic biomarkers. We used ANOVA analyses to compare metabolic outcomes between diagnostic and ethnic subgroups, linear regression models to examine associations between Mexican descent and metabolic outcomes, and Spearman's correlations to examine relationships between metabolic outcomes and illness-related variables in PwS. Mexican PwS had higher hemoglobin A1c levels, insulin resistance, and body mass index than NHW PwS. Mexican descent was associated with higher hemoglobin A1c levels, insulin resistance, body mass index, and leptin levels, controlling for age, sex, depression, education, and smoking. Among Mexican PwS, worse negative symptoms were associated with greater insulin resistance. These findings support the possibility of ethnicity-based differences in metabolic dysregulation, though further investigation is warranted to create targeted health interventions for Hispanic PwS.
C1 [Kwak, Paulyn P.; Ibarra, Cynthia; Hernandez, Alexa; Lee, Ellen E.] Univ Calif San Diego, Dept Psychiat, 9500 Gilman Dr, La Jolla, CA 92093 USA.
   [Kwak, Paulyn P.; Ibarra, Cynthia; Hernandez, Alexa; Jeste, Dilip; Lee, Ellen E.] Univ Calif San Diego, Sam & Rose Stein Inst Res Aging, 9500 Gilman Dr, La Jolla, CA 92093 USA.
   [Carrasco, Jessica; Lee, Ellen E.] Vet Affairs San Diego Healthcare Syst, Desert Pacific Mental Illness Res Educ & Clin Ctr, 3350 La Jolla Village Dr, San Diego, CA 92161 USA.
   [Sears, Dorothy D.] Univ Calif San Diego, Dept Med, 9500 Gilman Dr, La Jolla, CA 92093 USA.
   [Sears, Dorothy D.] Univ Calif San Diego, Dept Family Med, 9500 Gilman Dr, La Jolla, CA 92093 USA.
   [Sears, Dorothy D.] Arizona State Univ, Coll Hlth Solut, 550N 3rd St, Phoenix, AZ 85004 USA.
   [Marquine, Maria J.] Duke Univ, Duke Ctr Study Aging & Human Dev, Dept Med, Geriatr Div, 201 Trent Dr, Durham, NC 27710 USA.
   [Marquine, Maria J.] Duke Univ, Duke Ctr Study Aging & Human Dev, Dept Psychiat & Behav Sci, 201 Trent Dr, Durham, NC 27710 USA.
   [Lee, Ellen E.] Univ Calif San Diego, Dept Psychiat, 9500 Gilman Dr 0664, La Jolla, CA 92023 USA.
C3 University of California System; University of California San Diego;
   University of California System; University of California San Diego; US
   Department of Veterans Affairs; Veterans Health Administration (VHA); VA
   San Diego Healthcare System; University of California System; University
   of California San Diego; University of California System; University of
   California San Diego; Arizona State University; Arizona State
   University-Downtown Phoenix; Duke University; Duke University;
   University of California System; University of California San Diego
RP Lee, EE (corresponding author), Univ Calif San Diego, Dept Psychiat, 9500 Gilman Dr 0664, La Jolla, CA 92023 USA.
EM eel013@health.ucsd.edu
RI Lee, Ellen/AAV-7621-2020; Sears, Dorothy/B-6979-2019
OI Lee, Ellen/0000-0002-2250-765X
FU National Institute of Mental Health [R01MH094151-01, K23 MH119375-01];
   National Institutes of Health Grant [NIH UL1TR001442]; Brain & Behavior
   Research Foundation; Midcareer Investigator Award in Patient -Oriented
   Research [K24AG075240]; Desert -Pacific Mental Illness Research
   Education and Clinical Center at the VA San Diego Healthcare System;
   Stein Institute for Research on Aging at the University of California
   San Diego
FX This work was supported, in part, by the National Institute of Mental
   Health [an R01 grant (R01MH094151-01 to DVJ [PI] ) , a K23 grant (K23
   MH119375-01 to EEL [PI] , National Institutes of Health Grant NIH
   UL1TR001442 of CTSA (PI: Gary Firestein, MD) , A Havens Established
   Investigator Grant from The Brain & Behavior Research Foundation (PI:
   EEL) , a Midcareer Investigator Award in Patient -Oriented Research
   K24AG075240 (PI: MJM) , the Desert -Pacific Mental Illness Research
   Education and Clinical Center at the VA San Diego Healthcare System, as
   well as the Stein Institute for Research on Aging at the University of
   California San Diego. The content of this paper is solely the
   responsibility of the authors and does not necessarily represent the
   official views of the NIH. Aside from the funding sources listed above,
   the authors have no conflicts of interest to report.
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NR 84
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0165-1781
EI 1872-7123
J9 PSYCHIAT RES
JI Psychiatry Res.
PD APR
PY 2024
VL 334
AR 115788
DI 10.1016/j.psychres.2024.115788
EA FEB 2024
PG 9
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA MV4M2
UT WOS:001196397700001
PM 38401486
DA 2025-06-11
ER

PT J
AU Kattimani, S
   Subramanian, K
   Sarkar, S
   Rajkumar, RP
   Balasubramanian, S
AF Kattimani, Shivanand
   Subramanian, Karthick
   Sarkar, Siddharth
   Rajkumar, Ravi Philip
   Balasubramanian, Shanmuganathan
TI Lifetime suicide attempt in bipolar I disorder: its correlates and
   effect on illness course
SO INTERNATIONAL JOURNAL OF PSYCHIATRY IN CLINICAL PRACTICE
LA English
DT Article
DE Bipolar I; suicide attempt; course; sleep; adherence; India
ID SUBSTANCE USE DISORDERS; RISK-FACTORS; METABOLIC SYNDROME; SLEEP
   DISTURBANCE; STEP-BD; ADOLESCENTS; IDEATION; VALIDITY; COHORT; BEHAVIORS
AB Objectives: To identify the prevalence and correlates of bipolar I patients with a lifetime history of suicide attempt.
   Methods: Bipolar I disorder was diagnosed in 150 patients as per DSM-IV-TR criteria. Their lifetime suicide risk was assessed using the Columbia Suicide Severity Rating Scale. NIMH retrospective Life Chart Methodology was used to chart the illness course. Medication Adherence Rating Scale (MARS) and Pittsburgh Sleep Quality Index (PSQI) were used to assess the recent adherence and subjective sleep quality, respectively. The suicide attempters were compared with non-attempters on individual variables.
   Results: Around 23% had a positive lifetime history of suicide attempt. They were predominantly female, had an index (first ever) episode of depression, spent more proportion of time being ill, especially in depressive or mixed episode phase. Comorbid substance use disorder along with suicidal attempts was seen only in males. Suicide attempters displayed poor medication adherence attitudes for medications taken during the past week and reported impaired sleep quality for the previous month.
   Conclusions: A positive history of lifetime suicide attempt was significantly associated with a worse course of bipolar I disorder. Effective treatment of depressive episodes, addressing non-adherence, substance use and sleep problems can reduce the suicide risk in such patients. Retrospective design of the study and recall bias are some of the limitations.
C1 [Kattimani, Shivanand; Subramanian, Karthick; Rajkumar, Ravi Philip; Balasubramanian, Shanmuganathan] Jawaharlal Inst Post Grad Med Educ & Res, Dept Psychiat, Pondicherry, India.
   [Sarkar, Siddharth] All India Inst Med Sci, Dept Psychiat, New Delhi, India.
C3 Jawaharlal Institute of Postgraduate Medical Education & Research; All
   India Institute of Medical Sciences (AIIMS) New Delhi
RP Subramanian, K (corresponding author), Jawaharlal Inst Post Grad Med Educ & Res JIPMER, Dept Psychiat, Dhanvanthri Nagar 605006, Puducherry, India.
EM karthick.jipmer@gmail.com
RI Subramanian, Karthick/AAV-4876-2020
OI Subramanian, Karthick/0000-0001-7452-5713; Rajkumar,
   Ravi/0000-0003-2699-7438; KATTIMANI, SHIVANAND/0000-0002-9481-2784
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NR 60
TC 14
Z9 15
U1 0
U2 5
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1365-1501
EI 1471-1788
J9 INT J PSYCHIAT CLIN
JI Int. J. Psychiat. Clin.
PY 2017
VL 21
IS 2
BP 118
EP 124
DI 10.1080/13651501.2016.1250912
PG 7
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA EV1SO
UT WOS:000401526900007
PM 27854557
DA 2025-06-11
ER

PT J
AU Vancampfort, D
   Sienaert, P
   Wyckaert, S
   De Hert, M
   Stubbs, B
   Probst, M
AF Vancampfort, Davy
   Sienaert, Pascal
   Wyckaert, Sabine
   De Hert, Marc
   Stubbs, Brendon
   Probst, Michel
TI Sitting time, physical fitness impairments and metabolic abnormalities
   in people with bipolar disorder: An exploratory study
SO PSYCHIATRY RESEARCH
LA English
DT Article
DE Bipolar disorder; Depression; Sitting; Exercise; Metabolic syndrome;
   Physical fitness
ID MAJOR DEPRESSIVE DISORDER; REPORT QIDS-SR; SEDENTARY BEHAVIOR;
   CARDIOVASCULAR-DISEASE; HEALTHY CONTROLS; QUICK INVENTORY; EXERCISE;
   SCHIZOPHRENIA; MORTALITY; ADULTS
AB A sedentary lifestyle is an independent risk factor for cardiovascular disease and mortality. Little is known however about sedentary behavior in people with bipolar disorder (BD). The primary aim of this study was to explore associations between sitting time (as a proxy for a sedentary lifestyle) and physical fitness and metabolic parameters in BD. A secondary aim was to investigate associations between psychiatric symptoms, psychotropic medication use and sitting time. Thirty-nine (219) participants (43.7 +/- 12.4 years) completed a full metabolic screening, the sitting time item of the International Physical Activity Questionnaire, the Quick Inventory of Depressive Symptomatology self-report and the Hypomania Checklist-32. Additionally participants performed the Eurofit-test battery and 6-min walk test. The mean time spent sitting per day for the entire sample was 7.0 +/- 3.0 h. A higher body mass index, worse physical fitness and higher antipsychotic medication dose were identified as independent predictors of higher levels of sitting behavior. The model explained 76.5% of the variability in the sitting time. Given that a sedentary lifestyle is an independent predictor of cardiovascular disease, future interventions specifically targeting time spend sitting are warranted in BD, with a particular emphasis on those with high body mass index and low fitness levels. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
C1 [Vancampfort, Davy; Probst, Michel] Univ Leuven, KU Leuven, Dept Rehabil Sci, Leuven, Belgium.
   [Vancampfort, Davy; Sienaert, Pascal; Wyckaert, Sabine; De Hert, Marc] Univ Leuven, KU Leuven, Univ Psychiat Ctr, Kortenberg, Leuven, Belgium.
   [Stubbs, Brendon] South London & Maudsley NHS Fdn Trust, Physiotherapy Dept, London, England.
   [Stubbs, Brendon] Kings Coll London, Inst Psychiat Psychol & Neurosci, Hlth Serv & Populat Res Dept, De Crespigny Pk, London, England.
C3 KU Leuven; KU Leuven; South London & Maudsley NHS Trust; University of
   London; King's College London
RP Vancampfort, D (corresponding author), Leuvensesteenweg 517, B-3070 Kortenberg, Belgium.
EM Davy.Vancampfort@uc-kortenberg.be
RI De Hert, Marc/AAH-6090-2021; Stubbs, Brendon/X-1904-2018; Vancampfort,
   Davy/AAD-1987-2019; sienaert, pascal/HTP-4217-2023; Probst,
   Michel/ABE-6137-2020; Stubbs, Brendon/C-5696-2015
OI Stubbs, Brendon/0000-0001-7387-3791; De Hert, Marc/0000-0003-4255-5920;
   Sienaert, Pascal/0000-0002-0650-415X
FU Research Foundation - Flanders (FWO-Vlaanderen)
FX The first author receives funding from the Research Foundation -
   Flanders (FWO-Vlaanderen).
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NR 42
TC 16
Z9 16
U1 0
U2 5
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0165-1781
J9 PSYCHIAT RES
JI Psychiatry Res.
PD AUG 30
PY 2016
VL 242
BP 7
EP 12
DI 10.1016/j.psychres.2016.05.023
PG 6
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA DT9TC
UT WOS:000381844200002
PM 27235986
OA Green Accepted, Green Submitted
DA 2025-06-11
ER

PT J
AU Paavonen, EJ
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   Räikkönen, K
   Heinonen, K
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   Andersson, S
   Järvenpää, AL
   Eriksson, JG
   Kajantie, E
AF Paavonen, E. Juulia
   Strang-Karlsson, Sonja
   Raikkonen, Katri
   Heinonen, Kati
   Pesonen, Anu-Katriina
   Hovi, Petteri
   Andersson, Sture
   Jarvenpaa, Anna-Liisa
   Eriksson, Johan G.
   Kajantie, Eero
TI Very low birth weight increases risk for sleep-disordered breathing in
   young adulthood:: The Helsinki Study of very low birth weight adults
SO PEDIATRICS
LA English
DT Article
DE sleep-disordered breathing; snoring; prematurity; very low birth weight
ID BLOOD-PRESSURE; METABOLIC SYNDROME; APNEA SYNDROME; AGED CHILDREN;
   ASSOCIATION; CHILDHOOD; PREVALENCE; PRETERM; METAANALYSIS; PREMATURITY
AB OBJECTIVE. We investigated whether very low birth weight (< 1500 g) is associated with the risk of sleep-disordered breathing in young adulthood.
   METHODS. The study was a retrospective longitudinal study of 158 young adults born with very low birth weight and 169 term-born control subjects (aged 18.5-27.1 years). The principal outcome variable was sleep-disordered breathing defined as chronic snoring.
   RESULTS. The crude prevalence of chronic snoring was similar in both groups: 15.8% for the very low birth weight group versus 13.6% for the control group. However, after controlling for the confounding variables in multivariate logistic regression models (age, gender, current smoking, parental education, height, BMI, and depression), chronic snoring was 2.2 times more likely in the very low birth weight group compared with the control group. In addition, maternal smoking during pregnancy was significantly and independently of very low birth weight related to risk of sleep-disordered breathing. Maternal preeclampsia, standardized birth weight, and, for very low birth weight infants, small-for-gestational-age status were not related to sleep-disordered breathing.
   CONCLUSIONS. Premature infants with very low birth weight have a twofold risk of sleep-disordered breathing as young adults. In addition, maternal smoking during pregnancy increases the risk of sleep-disordered breathing by more than twofold.
C1 Univ Helsinki, Dept Psychol, Helsinki 00014, Finland.
   Univ Helsinki, Dept Psychol & Publ Hlth, Helsinki, Finland.
   Natl Publ Hlth Inst, Helsinki, Finland.
   Univ Helsinki, Cent Hosp, Hosp Children & Adolescents, Helsinki, Finland.
C3 University of Helsinki; University of Helsinki; Finland National
   Institute for Health & Welfare; University of Helsinki; Helsinki
   University Central Hospital
RP Paavonen, EJ (corresponding author), Univ Helsinki, Dept Psychol, PO Box 9, Helsinki 00014, Finland.
EM juulia.paavonen@helsinki.fi
RI Gibbs, J. Raphael/A-3984-2010; Paavonen, E./AAD-3528-2019
OI Raikkonen, Katri/0000-0003-3124-3470; Pesonen,
   Anu-Katriina/0000-0002-0662-6261; Hovi, Petteri/0000-0002-7790-007X;
   Heinonen, Kati/0000-0002-1262-5599; Andersson,
   Sture/0000-0001-9026-412X; Eriksson, Johan/0000-0002-2516-2060;
   Paavonen, Juulia/0000-0002-1421-9877
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NR 38
TC 88
Z9 94
U1 0
U2 5
PU AMER ACAD PEDIATRICS
PI ELK GROVE VILLAGE
PA 141 NORTH-WEST POINT BLVD,, ELK GROVE VILLAGE, IL 60007-1098 USA
SN 0031-4005
J9 PEDIATRICS
JI Pediatrics
PD OCT
PY 2007
VL 120
IS 4
BP 778
EP 784
DI 10.1542/peds.2007-0540
PG 7
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA 216HV
UT WOS:000249870000011
PM 17908765
DA 2025-06-11
ER

PT J
AU Bakac, ER
   Percin, E
   Gunes-Bayir, A
   Dadak, A
AF Bakac, Elif Rabia
   Percin, Ece
   Gunes-Bayir, Ayse
   Dadak, Agnes
TI A Narrative Review: The Effect and Importance of Carotenoids on Aging
   and Aging-Related Diseases
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE carotenoids; aging; aging-related diseases; oxidative stress;
   antioxidant; pro-oxidant
ID OXIDATIVE STRESS; METABOLIC SYNDROME; DIABETES-MELLITUS; LOWER
   PREVALENCE; BINDING PROTEIN; BETA-CAROTENE; ASTAXANTHIN; LUTEIN;
   LYCOPENE; RISK
AB Aging is generally defined as a time-dependent functional decline that affects most living organisms. The positive increase in life expectancy has brought along aging-related diseases. Oxidative stress caused by the imbalance between pro-oxidants and antioxidants can be given as one of the causes of aging. At the same time, the increase in oxidative stress and reactive oxygen species (ROS) is main reason for the increase in aging-related diseases such as cardiovascular, neurodegenerative, liver, skin, and eye diseases and diabetes. Carotenoids, a natural compound, can be used to change the course of aging and aging-related diseases, thanks to their highly effective oxygen-quenching and ROS-scavenging properties. Therefore, in this narrative review, conducted using the PubMed, ScienceDirect, and Google Scholar databases and complying with the Scale for the Assessment of Narrative Review Articles (SANRA) guidelines, the effects of carotenoids on aging and aging-related diseases were analyzed. Carotenoids are fat-soluble, highly unsaturated pigments that occur naturally in plants, fungi, algae, and photosynthetic bacteria. A large number of works have been conducted on carotenoids in relation to aging and aging-related diseases. Animal and human studies have found that carotenoids can significantly reduce obesity and fatty liver, lower blood sugar, and improve liver fibrosis in cirrhosis, as well as reduce the risk of cardiovascular disease and erythema formation, while also lowering glycated hemoglobin and fasting plasma glucose levels. Carotenoid supplementation may be effective in preventing and delaying aging and aging-related diseases, preventing and treating eye fatigue and dry eye disease, and improving macular function. These pigments can be used to stop, delay, or treat aging-related diseases due to their powerful antioxidant, restorative, anti-proliferative, anti-inflammatory, and anti-aging properties. As an increasingly aging population emerges globally, this review could provide an important prospective contribution to public health.
C1 [Bakac, Elif Rabia; Percin, Ece; Gunes-Bayir, Ayse] Bezmialem Vakif Univ, Fac Hlth Sci, Dept Nutr & Dietet, TR-34065 Istanbul, Turkiye.
   [Dadak, Agnes] Univ Vet Med Vienna, Inst Pharmacol & Toxicol, Clin Pharmacol, A-1210 Vienna, Austria.
C3 Bezmialem Vakif University; University of Veterinary Medicine Vienna
RP Gunes-Bayir, A (corresponding author), Bezmialem Vakif Univ, Fac Hlth Sci, Dept Nutr & Dietet, TR-34065 Istanbul, Turkiye.
EM agunes@bezmialem.edu.tr; agnes.dadak@vetmeduni.ac.at
RI Güneş Bayır, Ayşe/LXW-2765-2024
OI GUNES BAYIR, AYSE/0000-0002-9993-7850; Bakac, Elif
   Rabia/0009-0004-4708-0148
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NR 124
TC 19
Z9 19
U1 2
U2 19
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD OCT
PY 2023
VL 24
IS 20
AR 15199
DI 10.3390/ijms242015199
PG 16
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA W2JE0
UT WOS:001089936500001
PM 37894880
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Kumar, GG
   Kilari, EK
   Nelli, G
   Bin Salleh, N
AF Kumar, Gowri Gopa
   Kilari, Eswar Kumar
   Nelli, Giribabu
   Bin Salleh, Naguib
TI Oral administration of Turnera diffusa willd. ex Schult.
   extract ameliorates steroidogenesis and spermatogenesis impairment in
   the testes of rats with type-2 diabetes mellitus
SO JOURNAL OF ETHNOPHARMACOLOGY
LA English
DT Article
DE DM-Induced male infertility; T; diffusa; Testes; Oxidative stress;
   Inflammation; Steroidogenesis; Spermatogenesis
ID NF-KAPPA-B; ANDROGEN RECEPTOR COREGULATORS; OXIDATIVE STRESS;
   BLOOD-TESTIS; INSULIN-RESISTANCE; METABOLIC SYNDROME; WILD TURNERACEAE;
   SERTOLI-CELLS; EXPRESSION; BARRIER
AB Ethnopharmacological relevance: Turnera diffusa Willd. ex Schult. (T. diffusa) has traditionally been used to treat male reproductive dysfunction and have aphrodisiac properties.Aims of the study: This study aims to investigate the ability of T. diffusa to ameliorate the impairment in testicular steroidogenesis and spermatogenesis in DM that might help to improve testicular function, and sub-sequently restore male fertility.Materials and methods: DM-induced adult male rats were given 100 mg/kg/day and 200 mg/kg/day T. diffusa leaf extract orally for 28 consecutive days. Rats were then sacrificed; sperm and testes were harvested and sperm parameter analysis were performed. Histo-morphological changes in the testes were observed. Biochemical as-says were performed to measure testosterone and testicular oxidative stress levels. Immunohistochemistry and double immunofluorescence were used to monitor oxidative stress and inflammation levels in testes as well as Sertoli and steroidogenic marker proteins' expression.Results: Treatment with T. diffusa restores sperm count, motility, and viability near normal and reduces sperm morphological abnormalities and sperm DNA fragmentation in diabetic rats. T. diffusa treatment also reduces testicular NOX-2 and lipid peroxidation levels, increases testicular antioxidant enzymes (SOD, CAT, and GPx) activities, ameliorates testicular inflammation via downregulating NF-Kappa B, p-Ikk beta and TNF-alpha and upregulating I kappa B alpha expression. In diabetic rats, T. diffusa treatment increases testicular steroidogenic proteins (StAR, CYP11A1, SHBG, and ARA54, 3 and 17 beta-HSD) and plasma testosterone levels. Furthermore, in diabetic rats treated with T. diffusa, Sertoli cell marker proteins including Connexin 43, N-cadherin, and occludin levels in the testes were elevated.Conclusion: T. diffusa treatment could help to ameliorate the detrimental effects of DM on the testes, thus this plant has potential to be used to restore male fertility.
C1 [Kumar, Gowri Gopa; Nelli, Giribabu; Bin Salleh, Naguib] Univ Malaya, Fac Med, Dept Physiol, Kuala Lumpur 50603, Malaysia.
   [Kilari, Eswar Kumar] Andhra Univ, AU Coll Pharmaceut Sci, Pharmacol Div, Visakhapatnam 530003, Andhra Pradesh, India.
C3 Universiti Malaya; Andhra University
RP Nelli, G; Bin Salleh, N (corresponding author), Univ Malaya, Fac Med, Dept Physiol, Kuala Lumpur 50603, Malaysia.
EM nelli.giribabu@gmail.com; naguibsalleh@um.edu.my
RI Salleh, Naguib/ABG-6960-2021; Nelli, Giribabu/C-1203-2017; Salleh,
   Naguib/E-1213-2013
OI Nelli, Giribabu/0000-0001-7079-4289; Salleh, Naguib/0000-0002-4926-0490
FU AICTE RPS project , India [A.V. (3) /AICTE-RPS/2014]
FX This research is funded by AICTE RPS project grant no. A.V. (3)
   /AICTE-RPS/2014, India.
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NR 97
TC 4
Z9 4
U1 2
U2 5
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0378-8741
EI 1872-7573
J9 J ETHNOPHARMACOL
JI J. Ethnopharmacol.
PD OCT 5
PY 2023
VL 314
AR 116638
DI 10.1016/j.jep.2023.116638
EA MAY 2023
PG 16
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA J1PP3
UT WOS:001007398800001
PM 37187362
DA 2025-06-11
ER

PT J
AU Bhatti, SI
   Mindikoglu, AL
AF Bhatti, Sundus I.
   Mindikoglu, Ayse L.
TI The impact of dawn to sunset fasting on immune system and its clinical
   significance in COVID-19 pandemic
SO METABOLISM OPEN
LA English
DT Article
DE COVID-19; SARS-CoV-2; Coronavirus; Intermittent fasting; Ramadan
   fasting; Ramadan-associated intermittent fasting; Diurnal fasting;
   Immune system; Dawn to sunset fasting; Fasting; Inflammation; Oxidative
   stress; Autophagy
ID NECROSIS-FACTOR-ALPHA; OXIDATIVE STRESS; GUT MICROBIOME; INFLAMMATORY
   RESPONSES; FUNCTIONAL RECEPTOR; BODY-COMPOSITION; ADIPOSE-TISSUE;
   BLOOD-PRESSURE; LIPID PROFILE; RAMADAN
AB Dawn to sunset fasting, a type of intermittent fasting commonly practiced in the month of Ramadan, requires abstinence from food and drink from dawn to sunset. Dawn and dusk are two transition time zones of the day that play a critical role in the human circadian rhythm. Practicing dawn to sunset fasting requires the alignment of mealtimes and wake-sleep times with the human biological dawn and dusk. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) impairs immune cell responses at multiple levels and leads to severe Coronavirus Disease 2019 (COVID-19). It generates high levels of pro-inflammatory cytokines and chemokines, also known as a cytokine storm, leads to mitochondrial dysfunction and generation of excessive amounts of mitochondrial reactive oxygen species, downregulates autophagy to escape detection for unchecked replication, and alters gut microbiome composition. Severe cases of COVID-19 have been associated with several comorbidities that impair immune responses (e.g., obesity, diabetes, malignancy) and blood laboratory abnormalities (e.g., elevated procalcitonin, C-reactive protein, interleukin-6, leukocytosis, lymphopenia). Several studies of dawn to sunset fasting showed anti-inflammatory effect by suppressing several proinflammatory cytokines, reducing oxidative stress, inducing a proteome response associated with increased autophagy, remodeling the gut microbiome, and improving the components of metabolic syndrome (e.g., obesity, blood glucose levels, blood pressure, lipids). In conclusion, dawn to sunset fasting has the potential to optimize the immune system function against SARSCoV-2 during the COVID-19 pandemic as it suppresses chronic inflammation and oxidative stress, improves metabolic profile, and remodels the gut microbiome. This review presents scientific literature related to the effects of dawn to sunset fasting on the immune system. Studies are needed to assess and confirm the potential benefits of dawn to sunset fasting against SARS-CoV-2.
C1 [Bhatti, Sundus I.; Mindikoglu, Ayse L.] Baylor Coll Med, Margaret M & Albert B Alkek Dept Med, Sect Gastroenterol & Hepatol, Houston, TX USA.
   [Bhatti, Sundus I.; Mindikoglu, Ayse L.] Baylor Coll Med, Michael E DeBakey Dept Surg, Div Abdominal Transplantat, Houston, TX USA.
   [Mindikoglu, Ayse L.] Baylor Coll Med, Michael E DeBakey Dept Surg, Margaret M & Albert B Alkek Dept Med, Div Abdominal Transplantat,Sect Gastroenterol & He, 6620 Main St,Suite 1450, Houston, TX 77030 USA.
C3 Baylor College of Medicine; Baylor College of Medicine; Baylor College
   of Medicine
RP Mindikoglu, AL (corresponding author), Baylor Coll Med, Michael E DeBakey Dept Surg, Margaret M & Albert B Alkek Dept Med, Div Abdominal Transplantat,Sect Gastroenterol & He, 6620 Main St,Suite 1450, Houston, TX 77030 USA.
EM Ayse.Mindikoglu@bcm.edu
RI Mindikoglu, Ayse/HOF-9696-2023
OI Mindikoglu, Ayse/0000-0003-4598-8692
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NR 135
TC 7
Z9 8
U1 2
U2 5
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
EI 2589-9368
J9 METAB OPEN
JI Metab. Open
PD MAR
PY 2022
VL 13
AR 100162
DI 10.1016/j.metop.2021.100162
PG 11
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA JF8G1
UT WOS:001171837900007
PM 34977523
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Szucs, G
   Sója, A
   Péter, M
   Sárközy, M
   Bruszel, B
   Siska, A
   Földesi, I
   Szabó, Z
   Janáky, T
   Vígh, L
   Balogh, G
   Csont, T
AF Szucs, Gergo
   Soja, Andrea
   Peter, Maria
   Sarkozy, Marta
   Bruszel, Bella
   Siska, Andrea
   Foldesi, Imre
   Szabo, Zoltan
   Janaky, Tamas
   Vigh, Laszlo
   Balogh, Gabor
   Csont, Tamas
TI Prediabetes Induced by Fructose-Enriched Diet Influences Cardiac
   Lipidome and Proteome and Leads to Deterioration of Cardiac Function
   prior to the Development of Excessive Oxidative Stress and Cell Damage
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Article
ID FATTY LIVER-DISEASE; CARDIOVASCULAR-DISEASE; DIASTOLIC DYSFUNCTION;
   DIABETIC MYOCARDIUM; SHOTGUN LIPIDOMICS; METABOLIC SYNDROME;
   GENE-EXPRESSION; BARTH-SYNDROME; ANIMAL-MODELS; RAT-HEART
AB Prediabetes is a condition affecting more than 35% of the population. In some forms, excessive carbohydrate intake (primarily refined sugar) plays a prominent role. Prediabetes is a symptomless, mostly unrecognized disease which increases cardiovascular risk. In our work, we examined the effect of a fructose-enriched diet on cardiac function and lipidome as well as proteome of cardiac muscle. Male Wistar rats were divided into two groups. The control group received a normal diet while the fructose-fed group received 60% fructose-supplemented chow for 24 weeks. Fasting blood glucose measurement and oral glucose tolerance test (OGTT) showed slightly but significantly elevated values due to fructose feeding indicating development of a prediabetic condition. Both echocardiography and isolated working heart perfusion performed at the end of the feeding protocol demonstrated diastolic cardiac dysfunction in the fructose-fed group. Mass spectrometry-based, high-performance lipidomic and proteomic analyses were executed from cardiac tissue. The lipidomic analysis revealed complex rearrangement of the whole lipidome with special emphasis on defects in cardiolipin remodeling. The proteomic analysis showed significant changes in 75 cardiac proteins due to fructose feeding including mitochondria-, apoptosis-, and oxidative stress-related proteins. Nevertheless, just very weak or no signs of apoptosis induction and oxidative stress were detected in the hearts of fructose-fed rats. Our results suggest that fructose feeding induces marked alterations in the cardiac lipidome, especially in cardiolipin remodeling, which leads to mitochondrial dysfunction and impaired cardiac function. However, at the same time, several adaptive responses are induced at the proteome level in order to maintain a homeostatic balance. These findings demonstrate that even very early stages of prediabetes can impair cardiac function and can result in significant changes in the lipidome and proteome of the heart prior to the development of excessive oxidative stress and cell damage.
C1 [Szucs, Gergo; Soja, Andrea; Sarkozy, Marta; Csont, Tamas] Univ Szeged, Fac Med, Dept Biochem, Metab Dis & Cell Signaling Grp, H-6720 Szeged, Hungary.
   [Szucs, Gergo; Soja, Andrea; Sarkozy, Marta; Bruszel, Bella; Szabo, Zoltan; Janaky, Tamas; Csont, Tamas] Univ Szeged, Interdisciplinary Ctr Excellence, H-6720 Szeged, Hungary.
   [Peter, Maria; Vigh, Laszlo; Balogh, Gabor] Hungarian Acad Sci, Biol Res Ctr, Inst Biochem, H-6720 Szeged, Hungary.
   [Bruszel, Bella; Szabo, Zoltan; Janaky, Tamas] Univ Szeged, Fac Med, Inst Med Chem, H-6720 Szeged, Hungary.
   [Siska, Andrea; Foldesi, Imre] Univ Szeged, Fac Med, Dept Lab Med, H-6720 Szeged, Hungary.
C3 Szeged University; Szeged University; Hungarian Academy of Sciences;
   HUN-REN; HUN-REN Biological Research Center; Institute of Biochemistry -
   HAS; Szeged University; Szeged University
RP Szucs, G; Csont, T (corresponding author), Univ Szeged, Fac Med, Dept Biochem, Metab Dis & Cell Signaling Grp, H-6720 Szeged, Hungary.; Szucs, G; Csont, T (corresponding author), Univ Szeged, Interdisciplinary Ctr Excellence, H-6720 Szeged, Hungary.
EM szucs.gergo@med.u-szeged.hu; csont.tamas@med.u-szeged.hu
RI Szűcs, Gergő/O-8732-2019; Balogh, Gábor/AIC-8192-2022; Szabo,
   Zoltan/H-9983-2015; Sarkozy, Marta/G-1657-2016
OI Siska, Andrea/0000-0002-2252-7095; Szucs, Gergo/0000-0003-1874-2718;
   Janaky, Tamas/0000-0002-6466-8283; Szabo, Zoltan/0000-0001-8278-8038;
   Balogh, Gabor/0000-0002-4565-6850; Sarkozy, Marta/0000-0002-5929-2146
FU Janos Bolyai Research Scholarship of the Hungarian Academy of Sciences;
   New National Excellence Program of the Ministry of Human Capacities
   [UNKP-18-4-SZTE-63];  [GINOP 2.3.2-15-2016-00006];  [EFOP
   3.6.2-16-2017-00006];  [OTKA-NKFIH (K115990)];  [20391 3/2018/FEKUSTRAT]
FX We acknowledge the outstanding technical support of Flora Diana Gausz
   and Alexandra Fejes for blood sampling, oral glucose tolerance test,
   organ weight measurement, and frozen tissue sample preparation and of
   Ilona Ungi for anaesthetizing and shaving the animals for
   echocardiography and of Ferenc Pentek in the sample preparation for
   proteomics studies. This article was supported by the grants GINOP
   2.3.2-15-2016-00006, EFOP 3.6.2-16-2017-00006, OTKA-NKFIH (K115990), and
   20391 3/2018/FEKUSTRAT. Marta Sarkozy was supported by the Janos Bolyai
   Research Scholarship of the Hungarian Academy of Sciences and the New
   National Excellence Program of the Ministry of Human Capacities
   (UNKP-18-4-SZTE-63).
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NR 96
TC 31
Z9 35
U1 0
U2 18
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PD DEC 9
PY 2019
VL 2019
AR 3218275
DI 10.1155/2019/3218275
PG 21
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA JY1ZB
UT WOS:000504219500002
PM 31885782
OA Green Published, hybrid, Green Accepted
DA 2025-06-11
ER

PT S
AU Ripperger, JA
   Albrecht, U
AF Ripperger, Juergen A.
   Albrecht, Urs
BE Kalsbeek, A
   Merrow, M
   Roenneberg, T
   Foster, RG
TI The circadian clock component PERIOD2: From molecular to cerebral
   functions
SO NEUROBIOLOGY OF CIRCADIAN TIMING
SE Progress in Brain Research
LA English
DT Review; Book Chapter
DE metabolism; mood; synchronization; Per2
ID GENE-EXPRESSION; NEGATIVE LIMB; TRANSCRIPTION; MPER2; MUTANT;
   RHYTHMICITY; PER2; FEEDBACK; MUTATION; PROTEIN
AB The circadian clock is based on a molecular oscillator, which simulates the external day within nearly all of a body's cells. This "internalized" day then defines activity and rest phases for the cells and the organism by generating precise rhythms in the metabolism, physiology, and behavior. In its perfect state, this timing system allows for the synchronization of an organism to its environment and this may optimize energy handling and responses to daily recurring challenges. However, nowadays, we believe that desynchronization of an organism due to its lifestyle or problems with its circadian clock not only causes discomfort but also may aggravate conditions such as depression, metabolic syndrome, addiction, or cancer.
   In this review, we focus on one simple cogwheel of the mammalian circadian clock, the PERIOD2 (PER2) protein. Originally identified as an integral part of the molecular mechanism that yields overt rhythms of about 24 h, more recently multiple other functions have been identified. In essence, the PER proteins, in addition to their important function within the molecular oscillator, can be seen not only as integrators on the input side of the circadian clock but also as mediators of clock output. This diversity in their function is possible, because the PER proteins can interact with a multitude of other proteins transferring oscillator timing information to the latter. In this fashion, the circadian clock synchronizes many rhythmic processes.
C1 [Ripperger, Juergen A.; Albrecht, Urs] Univ Fribourg, Dept Biol, Biochem Unit, CH-1700 Fribourg, Switzerland.
C3 University of Fribourg
RP Ripperger, JA (corresponding author), Univ Fribourg, Dept Biol, Biochem Unit, CH-1700 Fribourg, Switzerland.
EM juergenalexandereduard.ripperger@unifr.ch
RI Albrecht, Urs/A-9831-2011
OI Albrecht, Urs/0000-0002-0663-8676
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NR 93
TC 24
Z9 26
U1 2
U2 19
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA SARA BURGERHARTSTRAAT 25, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0079-6123
BN 978-0-444-59427-3
J9 PROG BRAIN RES
JI Prog. Brain Res.
PY 2012
VL 199
BP 233
EP 245
DI 10.1016/B978-0-444-59427-3.00014-9
PG 13
WC Neurosciences
WE Book Citation Index – Science (BKCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA BC0QF
UT WOS:000349336900014
PM 22877669
DA 2025-06-11
ER

PT J
AU Vinereanu, D
   Mädler, CF
   Gherghinescu, C
   Ciobanu, AO
   Fraser, AG
AF Vinereanu, Dragos
   Maedler, Christopher F.
   Gherghinescu, Carmen
   Ciobanu, Andrea Olivia
   Fraser, Alan G.
TI Cumulative Impact of Cardiovascular Risk Factors on Regional Left
   Ventricular Function and Reserve: Progressive Long-Axis Dysfunction with
   Compensatory Radial Changes
SO ECHOCARDIOGRAPHY-A JOURNAL OF CARDIOVASCULAR ULTRASOUND AND ALLIED
   TECHNIQUES
LA English
DT Article
DE risk factors; stress echocardiography; tissue Doppler; ventricular
   function
ID CONGESTIVE-HEART-FAILURE; TISSUE DOPPLER-ECHOCARDIOGRAPHY; NORMAL
   EJECTION FRACTION; CORONARY-ARTERY-DISEASE; SYSTOLIC DYSFUNCTION;
   DIABETES-MELLITUS; SYSTEMIC HYPERTENSION; METABOLIC SYNDROME;
   CIGARETTE-SMOKING; STRAIN
AB Background: The risk factors that contribute to atherosclerosis also predict clinical heart failure, but it is unclear how they affect myocardial function. Aims were to assess if major cardiovascular risk factors cause subclinical myocardial dysfunction in asymptomatic subjects. Methods: We measured regional left ventricular (LV) function at rest and during dobutamine stress echocardiography in 246 subjects (54 +/- 12 years, 54% men) analyzed in five groups according to the presence of six risk factors (diabetes, hypertension, obesity, dyslipidemia, smoking, and family history; age was similar in the five groups). LV longitudinal function was assessed from the mean velocities of four basal segments, and radial function from the velocities of the basal posterior wall. Results: Risk factors did not affect LV ejection fraction, but longitudinal systolic velocity decreased progressively with the number of risk factors, at rest (6.8 +/- 1.3 vs. 6.2 +/- 1.6 vs. 5.8 +/- 1.5 vs. 5.4 +/- 1.3 vs. 5.3 +/- 1.3 cm/sec, for the five groups, respectively) and at peak stress (14.3 +/- 3.3 vs. 12.9 +/- 3.2 vs. 11.8 +/- 3.4 vs. 11.3 +/- 2.6 vs. 11.1 +/- 2.3 cm/sec) (both P < 0.0001). Radial systolic velocity increased according to the number of risk factors (P < 0.01). By multivariate regression, determinants of reduced longitudinal systolic velocity at rest were body mass index, diastolic blood pressure, age, and fasting plasma glucose (r = 0.57, r(2) = 0.32, P < 0.0001). Conclusion: Asymptomatic subjects have impaired LV long-axis function at rest and during stress, according to their number of major cardiovascular risk factors. Global LV systolic function is maintained by compensatory increases in radial function. These changes provide new targets for preclinical diagnosis and for monitoring responses to preventive strategies. (Echocardiography 2011;28:813-820)
C1 [Maedler, Christopher F.; Fraser, Alan G.] Wales Heart Res Inst, Cardiff, S Glam, Wales.
   [Vinereanu, Dragos; Gherghinescu, Carmen; Ciobanu, Andrea Olivia] Univ Med & Pharm Carol Davila, Bucharest, Romania.
C3 Cardiff University; Carol Davila University of Medicine & Pharmacy
RP Vinereanu, D (corresponding author), Univ Bucharest, Splaiul Independentei 169, Bucharest, Romania.
EM dvinereanu@yahoo.com
OI Vinereanu, Dragos/0000-0002-9054-8779; Ciobanu, Andrea
   Olivia/0000-0002-9868-4011
FU Menarini International, Italy
FX We gratefully acknowledge the contribution of all MYDISE study
   investigators (7) and ENESYS study investigators (ClinicalTrials.org:
   NCT00942487). The ENESYS study was partially supported by an
   unrestricted grant from Menarini International, Italy.
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NR 31
TC 13
Z9 15
U1 0
U2 1
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0742-2822
J9 ECHOCARDIOGR-J CARD
JI Echocardiography-J. Cardiovasc. Ultrasound Allied Tech.
PD SEP
PY 2011
VL 28
IS 8
BP 813
EP 820
DI 10.1111/j.1540-8175.2011.01456.x
PG 8
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 820NC
UT WOS:000294911700006
PM 21827541
DA 2025-06-11
ER

PT J
AU Othman, AI
   El-Sawi, MR
   El-Missiry, MA
   Abukhalil, MH
AF Othman, Azza I.
   El-Sawi, Mamdouh R.
   El-Missiry, Mohamed A.
   Abukhalil, Mohammad H.
TI Epigallocatechin-3-gallate protects against diabetic cardiomyopathy
   through modulating the cardiometabolic risk factors, oxidative stress,
   inflammation, cell death and fibrosis in
   streptozotocin-nicotinamide-induced diabetic rats
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Article
DE Diabetic heart; EGCG; Oxidative stress; Streptozotocin-nicotinamide;
   Cell death; Lipids
ID DOXORUBICIN-INDUCED CARDIOTOXICITY; GREEN TEA POLYPHENOLS;
   INSULIN-RESISTANCE; GALLATE EGCG; DNA-DAMAGE; EXPRESSION; APOPTOSIS;
   METABOLISM; ENZYMES; PLASMA
AB The potential protective effect of epigallocatechin-3-gallate (EGCG) on type 2 diabetes-induced heart injury was investigated. A rat model of diabetes was achieved by injection of nicotinamide (100 mg/kg, i.p), 20 min before the administration of streptozotocin (55 mg/kg, i.p.). After confirmation of diabetes, EGCG (2 mg/kg, p.o.) was administrated on alternate days for one month. Treatment of diabetic rats with EGCG showed a remarkable reduction in glucose, glycosylated hemoglobin, HOMA-IR and lipid profile levels with an elevation in insulin levels, indicating its antihyperglycemic and antidyslipidemic actions. EGCG treatment also suppressed the increase in the levels of superoxide, 4-hydroxynonenal and protein carbonyl, whereas it increased the content of glutathione and the activities of superoxide dismutase and catalase in heart of diabetic rats, indicating its antioxidant capacity. In addition, EGCG improved heart function of diabetic rats as evidenced by a remarkable reduction in troponin T level and creatine kinase-MB, lactate dehydrogenase and aspartate aminotransferase activities in the serum. Oral administration of EGCG for one month after diabetes induction significantly protected the increase in serum levels of proinflammatory cytokines (IL-1 beta, IL-6 and TNF-alpha) and adhesion molecules (ICAM-1 and VCAM-1), suggesting its anti-inflammatory potential. Furthermore, EGCG hampered the mitochondrial apoptotic pathway through increasing Bcl-2 level and decreasing p53, Bax, cytochrome c and caspase-3 and 9 levels in hearts of diabetic rats, indicating its anti-apoptotic action. Diabetic rats treated with EGCG also exhibited decreased level of DNA damage in the myocardium. The histological examinations indicated the cardioprotective effect of EGCG against harmful impact of diabetes. Therefore, these findings suggest that EGCG has a protective effect on the heart affected by type 2 diabetes and recommend it as a complementary supplement for diabetic patients. (C) 2017 Elsevier Masson SAS. All rights reserved.
C1 [Othman, Azza I.; El-Sawi, Mamdouh R.; El-Missiry, Mohamed A.; Abukhalil, Mohammad H.] Mansoura Univ, Zool Dept, Fac Sci, Mansoura, Egypt.
C3 Egyptian Knowledge Bank (EKB); Mansoura University
RP El-Missiry, MA (corresponding author), Mansoura Univ, Zool Dept, Fac Sci, Mansoura, Egypt.
EM maelmissiry@yahoo.com
RI othman, azza/O-3828-2018; abukhalil, Mohammad/H-5245-2017; El-Missiry,
   Mohamed Amr/L-9850-2018
OI El-Sawi, Mamdouh/0000-0001-8792-2136; abukhalil,
   Mohammad/0000-0002-4018-6925; El-Missiry, Mohamed
   Amr/0000-0002-4566-0497
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NR 57
TC 93
Z9 100
U1 1
U2 36
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD OCT
PY 2017
VL 94
BP 362
EP 373
DI 10.1016/j.biopha.2017.07.129
PG 12
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA FP6MU
UT WOS:000417741000039
PM 28772214
DA 2025-06-11
ER

PT J
AU Soontornniyomkij, V
   Lee, EE
   Jin, H
   Martin, AS
   Daly, RE
   Liu, JY
   Tu, XM
   Eyler, LT
   Jeste, DV
AF Soontornniyomkij, Virawudh
   Lee, Ellen E.
   Jin, Hua
   Martin, Averria Sirkin
   Daly, Rebecca E.
   Liu, Jinyuan
   Tu, Xin M.
   Eyler, Lisa Todd
   Jeste, Dilip, V
TI Clinical Correlates of Insulin Resistance in Chronic Schizophrenia:
   Relationship to Negative Symptoms
SO FRONTIERS IN PSYCHIATRY
LA English
DT Article
DE body mass index; cognitive function; depression; hemoglobin A1c;
   psychosis; antipsychotics
ID SERIOUS MENTAL-ILLNESS; HOMEOSTASIS MODEL ASSESSMENT; LIFE-STYLE
   INTERVENTION; DRUG-NAIVE PATIENTS; METABOLIC SYNDROME; COGNITIVE
   IMPAIRMENT; WEIGHT-LOSS; 1ST-EPISODE SCHIZOPHRENIA;
   CARDIOVASCULAR-DISEASE; TELEPHONE INTERVIEW
AB Higher prevalence of physical comorbidity and premature mortality in persons with schizophrenia (PwS) results primarily from heightened cardiovascular and metabolic risks. The literature suggests that insulin resistance precedes the development of obesity, smoking, and use of antipsychotic medications, although these likely play a compounding role later in the course of the disorder. It is thus important to discover the clinical characteristics of PwS with high insulin resistance, as these individuals may represent an etiopathologically distinct subgroup with a distinct course and treatment needs. We conducted a cross-sectional study and compared insulin resistance between 145 PwS and 140 nonpsychiatric comparison (NC) participants, similar in age, sex, and race distribution. In addition, we examined correlates of insulin resistance in PwS. As expected, PwS had higher levels of insulin resistance [Homeostatic Model Assessment of Insulin Resistance (HOMA-IR)] and body mass index (BMI) compared to the NC participants. HOMA-IR in the PwS was most associated with negative symptoms, BMI, and non-White race/ethnicity. The mechanistic relationships between insulin resistance and negative symptoms in schizophrenia patients warrant further investigation, and future studies should examine outcomes of PwS with this cluster of physical and mental symptoms and determine how management of insulin resistance might improve health of these individuals.
C1 [Soontornniyomkij, Virawudh; Lee, Ellen E.; Jin, Hua; Martin, Averria Sirkin; Daly, Rebecca E.; Eyler, Lisa Todd; Jeste, Dilip, V] Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA.
   [Lee, Ellen E.; Martin, Averria Sirkin; Daly, Rebecca E.; Liu, Jinyuan; Tu, Xin M.; Jeste, Dilip, V] Univ Calif San Diego, Sam & Rose Stein Inst Res Aging, La Jolla, CA 92093 USA.
   [Liu, Jinyuan; Tu, Xin M.] Univ Calif San Diego, Dept Family Med & Publ Hlth, La Jolla, CA 92093 USA.
   [Eyler, Lisa Todd] Vet Affairs San Diego Healthcare Syst, Desert Pacific Mental Illness Res Educ & Clin Ctr, San Diego, CA 92161 USA.
   [Jeste, Dilip, V] Univ Calif San Diego, Ctr Hlth Aging, La Jolla, CA 92093 USA.
   [Jeste, Dilip, V] Univ Calif San Diego, Dept Neurosci, La Jolla, CA 92093 USA.
C3 University of California System; University of California San Diego;
   University of California System; University of California San Diego;
   University of California System; University of California San Diego; US
   Department of Veterans Affairs; Veterans Health Administration (VHA); VA
   San Diego Healthcare System; University of California System; University
   of California San Diego; University of California System; University of
   California San Diego
RP Eyler, LT (corresponding author), Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA.; Eyler, LT (corresponding author), Vet Affairs San Diego Healthcare Syst, Desert Pacific Mental Illness Res Educ & Clin Ctr, San Diego, CA 92161 USA.
EM lteyler@ucsd.edu
RI jin, hua/AAX-1569-2020; Lee, Ellen/AAV-7621-2020; Eyler,
   Lisa/AAQ-4337-2021; Soontornniyomkij, Virawudh/C-7852-2009
OI Lee, Ellen/0000-0002-2250-765X; Soontornniyomkij,
   Virawudh/0000-0002-0471-7020
FU United States National Institutes of Health (NIH) [R01MH094151-01,
   MH019934]; NARSAD Young Investigator grant from the Brain and Behavior
   Research Foundation; Stein Institute for Research on Aging at the
   University of California San Diego; NIH [R56 AG059437]; United States
   National Institutes of Health (NIH) [CTSA funding] [UL1TR001442]
FX This work was supported by the United States National Institutes of
   Health (NIH) [grants R01MH094151-01 to DJ (PI), MH019934 to DJ (PI), and
   Grant UL1TR001442 of CTSA funding], NARSAD Young Investigator grant from
   the Brain and Behavior Research Foundation (PI: Ellen E. Lee, MD) and by
   the Stein Institute for Research on Aging at the University of
   California San Diego. VS was supported by NIH Grant R56 AG059437. The
   content is solely the responsibility of the authors and does not
   necessarily represent the official views of the NIH.
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NR 86
TC 18
Z9 20
U1 0
U2 2
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-0640
J9 FRONT PSYCHIATRY
JI Front. Psychiatry
PD APR 23
PY 2019
VL 10
AR 251
DI 10.3389/fpsyt.2019.00251
PG 9
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA HU9UL
UT WOS:000465639300001
PM 31065243
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Kim, HB
   So, WY
AF Kim, Han-Byul
   So, Wi-Young
TI EFFECT OF SIXTEEN WEEKS OF COMBINED EXERCISE ON BODY COMPOSITION,
   PHYSICAL FITNESS AND COGNITIVE FUNCTION IN KOREAN CHILDREN
SO SOUTH AFRICAN JOURNAL FOR RESEARCH IN SPORT PHYSICAL EDUCATION AND
   RECREATION
LA English
DT Article
DE Body composition; Cognitive function; Combined exercise;
   Electroencephalography activation; Physical fitness; Youth
ID METABOLIC SYNDROME; PERFORMANCE; INTERVENTIONS; ADOLESCENTS; DEPRESSION;
   HEALTH
AB This study examined the effects of 16-week combined exercise programme on body composition, physical fitness and cognitive function of Korean children. The 20 participants were randomly assigned to the Combined Exercise Training (CET) (resistance exercise and aerobics) group (n=10) or a control group (CG n=10). The CET group performed 90-min exercise sessions twice per week for 16 weeks, including 40min of resistance exercise, 40min of aerobic exercise and 10min warm-up and cool-down. The CG did not participate in any exercise or physical activity. Body composition variables (weight, body mass index, fat-free mass, per cent body fat, and basal metabolic rate) were measured using bio-electrical impedance analysis. Subjects underwent a physical fitness test consisting of sit-ups, grip strength, sit-and-reach, standing long jump, side-steps and isokinetic leg extension strength. The cognitive function test consisted of electro-encephalography (EEG) activation and the Stroop test. Significant interaction effects (time x group) on EEG activation (brain activity) in the Fp1 (p=0.034), F3 (p=0.028), and C4 (p=0.013) areas and Stroop test (cognitive function) (p=0.005) were observed in the CET group compared to the CG There were no interaction effects (time x group) on body composition or physical fitness variables. The CET affected the cognitive function of Korean children positively.
C1 [Kim, Han-Byul] Korea Natl Sport Univ, Dept Sport Psychol, Seoul, South Korea.
   [So, Wi-Young] Korea Natl Univ Transportat, Coll Humanities & Arts, Chungju Si 380702, Chungbuk, South Korea.
C3 Korea National Sport University; Korea National University of
   Transportation
RP So, WY (corresponding author), Korea Natl Univ Transportat, Coll Humanities & Arts, 50 Daehak Ro, Chungju Si 380702, Chungbuk, South Korea.
EM wowso@ut.ac.kr
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NR 43
TC 5
Z9 5
U1 0
U2 23
PU STELLENBOSCH UNIV
PI MATIELAND
PA MARKETING & COMMUNICATION SECTION, PRIVATE BAG X1, MATIELAND, 7602,
   SOUTH AFRICA
SN 0379-9069
J9 S AFR J RES SPORT PH
JI S. Afr. J. Res. Sport. Phys. Educ. R.
PY 2015
VL 37
IS 1
BP 47
EP 57
PG 11
WC Social Sciences, Interdisciplinary
WE Social Science Citation Index (SSCI)
SC Social Sciences - Other Topics
GA CO8BQ
UT WOS:000359390400004
DA 2025-06-11
ER

PT J
AU Zheng, K
   Wu, MD
   Cao, YJ
   Wang, JH
   Zhu, HJ
   Li, BW
   Yang, YF
   Hu, Y
   Ren, QT
   Lan, XH
   Pan, XM
AF Zheng, Kun
   Wu, Mengdi
   Cao, Yanjie
   Wang, Junhua
   Zhu, Huijing
   Li, Bowen
   Yang, Yifeng
   Hu, Yue
   Ren, Qitao
   Lan, Xiaohua
   Pan, Xiuming
TI Circadian syndrome and mortality risk in adults aged ≥ 40 years: a
   prospective cohort analysis of CHARLS and NHANES
SO SCIENTIFIC REPORTS
LA English
DT Article
DE Circadian syndrome; All-cause; CHARLS; NHANES; Mortality
ID ALL-CAUSE MORTALITY; METABOLIC SYNDROME; SLEEP DURATION; RHYTHMS;
   METAANALYSIS; ASSOCIATION; DEPRESSION
AB Circadian rhythm disruption is increasingly prevalent and associated with higher morbidity and mortality. This study investigates the relationship between Circadian Rhythm Syndrome (CircS) and mortality in middle-aged and older adults. This prospective cohort study utilized mortality follow-up data from the China Health and Retirement Longitudinal Study (CHARLS) and the National Health and Nutrition Examination Survey (NHANES). Cox proportional hazards models examined the association between CircS and all-cause mortality, while restricted cubic spline analysis explored non-linear relationships. Subgroup analyses investigated potential modifying factors. Cox models and Bayesian generalized linear models were used to explore relationships between CircS and specific causes of death. The study included 7,637 participants from CHARLS (2011-2020) and 9,320 participants from NHANES (2005-2018), with 142 and 1,321 all-cause deaths. The follow-up periods were 9.17 years for CHARLS and 15 years for NHANES. CircS was significantly associated with increased all-cause mortality risk (CHARLS: HR 1.79, 95% CI: 1.23-2.62; NHANES: HR 1.21, 95% CI: 1.03-1.42). A linear dose-response relationship was observed between the number of CircS components and mortality risk. CircS was positively associated with mortality from diabetes, cardiovascular, cerebrovascular, and kidney-related diseases. CircS is strongly associated with increased mortality risk. These findings underscore the importance of addressing circadian disruptions in public health strategies.
C1 [Zheng, Kun; Wang, Junhua; Yang, Yifeng] Air Force Med Ctr, Dept Cardiol, Beijing 100142, Peoples R China.
   [Zheng, Kun; Wu, Mengdi; Yang, Yifeng; Hu, Yue; Ren, Qitao] China Med Univ, Grad Sch, Shenyang 110122, Liao Ning Prov, Peoples R China.
   [Wu, Mengdi; Cao, Yanjie] Air Force Med Ctr, Dept Geriatr, Beijing 100142, Peoples R China.
   [Zhu, Huijing; Li, Bowen; Lan, Xiaohua; Pan, Xiuming] Hebei North Univ, Zhangjiakou 075000, Hebei, Peoples R China.
C3 China Medical University; Hebei North University
RP Cao, YJ (corresponding author), Air Force Med Ctr, Dept Geriatr, Beijing 100142, Peoples R China.
EM 18610089727@163.com
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NR 39
TC 0
Z9 0
U1 9
U2 9
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD APR 28
PY 2025
VL 15
IS 1
AR 14791
DI 10.1038/s41598-025-99631-3
PG 12
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 2BC7U
UT WOS:001478444700047
PM 40295832
OA gold
DA 2025-06-11
ER

PT J
AU Nishida, Y
   Anzai, T
   Takahashi, K
   Kozuma, T
   Kanda, E
   Yamauchi, K
   Katsukawa, F
AF Nishida, Yuki
   Anzai, Tatsuhiko
   Takahashi, Kunihiko
   Kozuma, Takahide
   Kanda, Eiichiro
   Yamauchi, Keita
   Katsukawa, Fuminori
TI Multimorbidity patterns in the working age population with the top 10%
   medical cost from exhaustive insurance claims data of Japan Health
   Insurance Association
SO PLOS ONE
LA English
DT Article
ID DEPRESSION
AB Although the economic burden of multimorbidity is a growing global challenge, the contribution of multimorbidity in patients with high medical expenses remains unclear. We aimed to clarify multimorbidity patterns that have a large impact on medical costs in the Japanese population. We conducted a cross-sectional study using health insurance claims data provided by the Japan Health Insurance Association. Latent class analysis (LCA) was used to identify multimorbidity patterns in 1,698,902 patients who had the top 10% of total medical costs in 2015. The present parameters of the LCA model included 68 disease labels that were frequent among this population. Moreover, subgroup analysis was performed using a generalized linear model (GLM) to assess the factors influencing annual medical cost and 5-year mortality. As a result of obtaining 30 latent classes, the kidney disease class required the most expensive cost per capita, while the highest portion (28.6%) of the total medical cost was spent on metabolic syndrome (MetS) classes, which were characterized by hypertension, dyslipidemia, and type 2 diabetes. GLM applied to patients with MetS classes showed that cardiovascular diseases or complex conditions, including malignancies, were powerful determinants of medical cost and mortality. MetS was classified into 7 classes based on real-world data and accounts for a large portion of the total medical costs. MetS classes with cardiovascular diseases or complex conditions, including malignancies, have a significant impact on medical costs and mortality.
C1 [Nishida, Yuki; Anzai, Tatsuhiko; Takahashi, Kunihiko] Tokyo Med & Dent Univ, M&D Data Sci Ctr, Dept Biostat, Tokyo, Japan.
   [Nishida, Yuki; Yamauchi, Keita] Keio Univ, Grad Sch Hlth Management, Yokohama, Kanagawa, Japan.
   [Nishida, Yuki; Katsukawa, Fuminori] Keio Univ, Sports Med Res Ctr, Yokohama, Kanagawa, Japan.
   [Kozuma, Takahide] Keio Univ, Sch Med, Dept Internal Med, Tokyo, Japan.
   [Kanda, Eiichiro] Kawasaki Med Sch, Med Sci, Okayama, Japan.
C3 Institute of Science Tokyo; Tokyo Medical & Dental University (TMDU);
   Keio University; Keio University; Keio University; Kawasaki Medical
   School
RP Katsukawa, F (corresponding author), Keio Univ, Sports Med Res Ctr, Yokohama, Kanagawa, Japan.
EM fuminori@keio.jp
RI NISHIDA, YUKI/LZH-2985-2025; Takahashi, Kunihiko/I-7104-2014
OI Takahashi, Kunihiko/0000-0003-2387-7772
FU The authors would like to thank Takehiko Baba and Yosuke Ihara for their
   technical assistance and knowledge of insurance societies. We are also
   grateful to Nobuki Ando, the chairman of the Japan Health Insurance
   Association, and all the relevant staff for
FX The authors would like to thank Takehiko Baba and Yosuke Ihara for their
   technical assistance and knowledge of insurance societies. We are also
   grateful to Nobuki Ando, the chairman of the Japan Health Insurance
   Association, and all the relevant staff for providing the opportunity to
   conduct this study.
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NR 48
TC 3
Z9 3
U1 2
U2 6
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD SEP 28
PY 2023
VL 18
IS 9
AR e0291554
DI 10.1371/journal.pone.0291554
PG 21
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA T5QM7
UT WOS:001078533700045
PM 37768909
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Nagahara, R
   Matono, T
   Sugihara, T
   Matsuki, Y
   Yamane, M
   Okamoto, T
   Miyoshi, K
   Nagahara, T
   Okano, J
   Koda, M
   Isomoto, H
AF Nagahara, Ran
   Matono, Tomomitsu
   Sugihara, Takaaki
   Matsuki, Yukako
   Yamane, Masafumi
   Okamoto, Toshiaki
   Miyoshi, Kenichi
   Nagahara, Takakazu
   Okano, Jun-ichi
   Koda, Masahiko
   Isomoto, Hajime
TI Gene Expression Analysis of the Activating Factor 3/Nuclear Protein 1
   Axis in a Non-alcoholic Steatohepatitis Mouse Model
SO YONAGO ACTA MEDICA
LA English
DT Article
DE endoplasmic reticulum stress; mouse model; nonalcoholic fatty liver
   disease; nonalcoholic steatohepatitis
ID ENDOPLASMIC-RETICULUM STRESS; FATTY LIVER-DISEASE; PATHOGENESIS; ATF3;
   P8; REGULATOR; PATHWAYS; ACTS; MICE; TNF
AB Background Nonalcoholic fatty liver disease/steatohepatitis (NAFLD/NASH) is a chronic liver disease related to metabolic syndrome that can progress to liver cirrhosis. The involvement of the endoplasmic reticulum (ER) stress response in NAFLD progression and the roles played by activating factor 3 (ATF3) and the downstream nuclear protein 1 (NUPR1) are poorly understood. The aim of this study was to determine the gene expression profiles around the ATF3/NUPR1 axis in relation to the development of NAFLD using novel mouse models.
   Methods Fatty liver Shionogi (FLS) mice (n = 12) as a NAFLD model and FLS-ob/ob mice (n = 28) as a NASH model were fed a standard diet. The FLS mice were sacrificed at 24 weeks of age as a control, whereas the FLS-ob/ob mice were sacrificed at 24, 36, and 48 weeks of age. Hepatic steatosis, inflammation, and fibrosis were evaluated by biochemical, histological, and gene expression analyses. The expression levels of the ER-stress related genes Jun proto-oncogene (C-jun), Atf3, Nupr1, and C/EBP homologous protein (Chop) were measured in liver tissue. Apoptosis was evaluated by terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) staining.
   Results Control mice demonstrated hepatic steatosis alone without apparent fibrosis. On the other hand, FLS-ob/ob mice showed severe steatohepatitis at both 24 and 36 weeks of age and severe fibrosis at both 36 and 48 weeks of age. The expression levels of Atf3, Nupr-1, and C-jun significantly increased from 24 to 48 weeks of age in FLS-ob/ob mice compared with control mice. The expression level of Chop was already high in FLS mice and maintained similar levels in FLS-ob/ob mice; the expression level was consistent with the percentage of TUNEL-positive cells.
   Conclusion The ATF3/NUPR1 axis plays a pivotal role in NASH progression in association with C-jun and Chop and appears to induce apoptosis from early steatosis in the NASH model mice.
C1 [Nagahara, Ran; Matono, Tomomitsu; Sugihara, Takaaki; Matsuki, Yukako; Yamane, Masafumi; Okamoto, Toshiaki; Miyoshi, Kenichi; Nagahara, Takakazu; Okano, Jun-ichi; Koda, Masahiko; Isomoto, Hajime] Tottori Univ, Fac Med, Div Med & Clin Sci, Dept Multidisciplinary Internal Med,Sch Med, Yonago, Tottori 6838504, Japan.
C3 Tottori University
RP Matono, T (corresponding author), Tottori Univ, Fac Med, Div Med & Clin Sci, Dept Multidisciplinary Internal Med,Sch Med, Yonago, Tottori 6838504, Japan.
EM matono@tottori-u.ac.jp
FU JSPS KAKENHI [JP16K19343]
FX This study was supported by a JSPS KAKENHI Grant-in-Aid for Young
   Scientists (B), Grant Number JP16K19343.
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PU TOTTORI UNIV MEDICAL PRESS
PI YONAGO
PA 86 NISHI-CHO, YONAGO, TOTTORI-KEN 683-8503, JAPAN
SN 0513-5710
EI 1346-8049
J9 YONAGO ACTA MED
JI Yonago Acta Med.
PD MAR
PY 2019
VL 62
IS 1
BP 36
EP 46
DI 10.33160/yam.2019.03.006
PG 11
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA HS4TX
UT WOS:000463861900006
PM 30962743
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Kilic, E
   Özer, ÖF
   Erek, AT
   Erman, H
   Torun, E
   Ayhan, SK
   Caglar, HG
   Selek, S
   Kocyigit, A
AF Kilic, Elif
   Ozer, Omer Faruk
   Erek, Aybala Toprak
   Erman, Hayriye
   Torun, Emel
   Ayhan, Siddika Kesgin
   Caglar, Hifa Gulru
   Selek, Sahbettin
   Kocyigit, Abdurrahim
TI Oxidative Stress Status in Childhood Obesity: A Potential Risk Predictor
SO MEDICAL SCIENCE MONITOR
LA English
DT Article
DE Antioxidants; Oxidative Stress; Pediatric Obesity; Sulfhydryl Reagents
ID INSULIN-RESISTANCE; METABOLIC SYNDROME; ADIPOSE-TISSUE; NADPH OXIDASES;
   INFLAMMATION; ANTIOXIDANT; REDOX; CHILDREN; CONSEQUENCES; MITOCHONDRIA
AB Background: Childhood obesity characterized by excessive fat in the body is one of the most serious health problems worldwide due to the social, medical, and physiological complications. Obesity and associated diseases are triggering factors for oxidative stress and inflammation. The aim of this study was to explore the possible association between childhood obesity and inflammatory and oxidative status.
   Material/Methods: Thirty-seven obese children and 37 healthy controls selected from among children admitted to BLIND University Paediatrics Department were included in the study. Anthropometric measurements were performed using standard methods. Glucose, lipid parameters, CRP, insulin, total oxidant status (TOS), total anti-oxidant status (TAS) levels, and total thiol levels (TTL) were measured in serum. HOMA index (HOMA-IR) were calculated. The differences between the groups were evaluated statistically using the Mann-Whitney U test.
   Results: Body mass index was significantly higher in the obese group (median: 28.31(p<0.001). Glucose metabolism, insulin, and HOMA-IR levels were significantly higher in the obese group (both p<0.001). Total cholesterol, HDL cholesterol, LDL cholesterol, and triglyceride levels were significantly higher in the obese group (p<0.001). TAS (med: 2.5 mu mol Trolox eq/L (1.7-3.3)) and TOS (med: 49.1 mu mol H2O2 eq/L (34.5-78.8)) levels and TTL (med: 0.22 mmol/L (0.16-0.26)) were significantly higher in the obese group (p=0.001). CRP levels showed positive correlation with TOS and negative correlation with TTL levels (p=0.005, r=0.473; p=0.01, r=-0.417; respectively). TTL levels exhibited negative correlation with TOS levels (p=0.03, r=-0.347).
   Conclusions: In conclusion, obese children were exposed to more oxidative burden than children with normal weight. Increased systemic oxidative stress induced by childhood obesity can cause development of obesity-related complications and diseases. Widely focussed studies are required on the use of oxidative parameters as early prognostic parameters in detection of obesity-related complications.
C1 [Kilic, Elif; Ozer, Omer Faruk; Ayhan, Siddika Kesgin; Caglar, Hifa Gulru; Selek, Sahbettin; Kocyigit, Abdurrahim] Bezmialem Vakif Univ, Fac Med, Dept Biochem, Istanbul, Turkey.
   [Erek, Aybala Toprak; Erman, Hayriye] Medeniyet Univ, Fac Med, Dept Biochem, Istanbul, Turkey.
   [Torun, Emel] Bezmialem Vakif Univ, Fac Med, Dept Paediat, Istanbul, Turkey.
C3 Bezmialem Vakif University; Istanbul Medeniyet University; Bezmialem
   Vakif University
RP Kilic, E (corresponding author), Bezmialem Vakif Univ, Fac Med, Dept Biochem, Istanbul, Turkey.
EM drelifkilic@gmail.com
RI Caglar, Hifa/AAH-1085-2020; Uzun, Hafize/D-4811-2019; torun,
   emel/NKP-0985-2025; Kocyigit, Abdurrahim/P-8685-2019; Ayık Kılıç,
   Elif/MZS-4228-2025; SELEK, Sahabettin/N-9323-2019; Ozer, Omer
   Faruk/Y-2516-2018
OI SELEK, Sahabettin/0000-0003-1235-3957; Ozer, Omer
   Faruk/0000-0002-9034-4805
CR [Anonymous], 2014, World Health Statistics full report World Health Organization
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NR 40
TC 34
Z9 36
U1 1
U2 12
PU INT SCIENTIFIC LITERATURE, INC
PI SMITHTOWN
PA 361 FOREST LANE, SMITHTOWN, NY 11787 USA
SN 1643-3750
J9 MED SCI MONITOR
JI Med. Sci. Monitor
PD OCT 13
PY 2016
VL 22
BP 3673
EP 3679
DI 10.12659/MSM.897965
PG 7
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA DY5JK
UT WOS:000385135600001
PM 27733746
OA Green Published
DA 2025-06-11
ER

PT J
AU Njajou, OT
   Kanaya, AM
   Holvoet, P
   Connelly, S
   Strotmeyer, ES
   Harris, TB
   Cummings, SR
   Hsueh, WC
AF Njajou, Omer T.
   Kanaya, Alka M.
   Holvoet, Paul
   Connelly, Stephanie
   Strotmeyer, Elsa S.
   Harris, Tamara B.
   Cummings, Steve R.
   Hsueh, Wen-Chi
CA Hlth ABC Study
TI Association between oxidized LDL, obesity and type 2 diabetes in a
   population-based cohort, the Health, Aging and Body Composition Study
SO DIABETES-METABOLISM RESEARCH AND REVIEWS
LA English
DT Article
DE oxLDL; diabetes; oxidation; obesity
ID LOW-DENSITY-LIPOPROTEIN; OXIDATIVE STRESS; INSULIN-RESISTANCE; METABOLIC
   SYNDROME; PLASMA; RISK; GLUCOSE; PROTEIN; ADIPONECTIN; CHOLESTEROL
AB Background Accumulating evidence suggests a cross-sectional association between oxidative stress and type 2 diabetes (T2D). Systemic oxidative stress, as measured by oxidized LDL (oxLDL), has been correlated with visceral fat. We examined the relationship between oxLDL, and T2D- and obesity-related traits in a bi-racial sample of 2985 subjects at baseline and after 7 years of follow-up.
   Methods We examined six T2D-related traits (T2D status, HbA(1c), fasting glucose, insulin, adiponectin and HOMA-IR) as well as six obesity-related traits (obesity status, BMI, leptin, % body fat, visceral and subcutaneous fat mass) using logistic and linear regression models.
   Results In all subjects at baseline, oxLDL was positively associated with T2D (OR = 1.3, 95% CI:1.1-1.5), fasting glucose (beta = 0.03 +/- 0.006), HbA(1c) (beta = 0.02 +/- 0.004), fasting insulin (beta = 0.12 +/- 0.02), HOMA-IR (beta = 0.13 +/- 0.02) and negatively with adiponectin (beta = -0.16 +/- 0.03), (all p < 0.001). The strength and magnitude of these associations did not differ much between blacks and whites. in both blacks and whites, oxLDL was also associated with obesity (OR = 1.3, 95% CI:1.1-1.4) and three of its related traits (beta = 0.60 +/- 0.14 for BMI, beta = 0.74 +/- 0.17 for % body fat, beta = 0.29 +/- 0.06 for visceral fat; all p < 0.001). Furthermore, of four traits measured after 7 years of follow-up (fasting glucose, HbA1c, BMI and % fat), their relationship with oxLDL was similar to baseline observations. No significant association was found between oxLDL and incident T2D. interestingly oxLDL was significantly associated with % change in T2D- and, obesity-related traits in whites but not in blacks.
   Conclusion/Interpretation Our data suggest that systemic oxidative stress may be a novel risk factor for T2D and obesity. Copyright (C) 2009 John Wiley & Sons, Ltd.
C1 [Hsueh, Wen-Chi] Univ Calif San Francisco, Sch Med, Dept Med, Inst Human Genet, San Francisco, CA 94143 USA.
   [Holvoet, Paul] Katholieke Univ Leuven, Louvain, Belgium.
   [Connelly, Stephanie] Univ Tennessee, Memphis, TN USA.
   [Strotmeyer, Elsa S.] Univ Pittsburgh, Pittsburgh, PA 15260 USA.
   [Harris, Tamara B.] NIA, Lab Epidemiol Demog & Biometry, Bethesda, MD 20892 USA.
C3 University of California System; University of California San Francisco;
   KU Leuven; University of Tennessee System; University of Tennessee
   Health Science Center; Pennsylvania Commonwealth System of Higher
   Education (PCSHE); University of Pittsburgh; National Institutes of
   Health (NIH) - USA; NIH National Institute on Aging (NIA)
RP Hsueh, WC (corresponding author), Univ Calif San Francisco, Sch Med, Dept Med, Inst Human Genet, 513 Parnassus Ave,HSE 672C, San Francisco, CA 94143 USA.
EM wen-chi.hsueh@ucsf.edu
RI HOLVOET, PAUL/T-8434-2017; Strotmeyer, Elsa/F-3015-2014
OI Strotmeyer, Elsa/0000-0002-4093-6036
FU Intramural Research Program of the National Institute on Aging; NIH
   [N01-AG-6-2101, N01-AG-6-2103, N01-AG-6-2106]; Interuniversity
   Attraction Poles Program [P6/30];  [K01 AG022782]
FX This study was supported in part by the Intramural Research Program of
   the National Institute on Aging, NIH contracts (N01-AG-6-2101,
   N01-AG-6-2103 and N01-AG-6-2106) and grant K01 AG022782. This work was
   also supported by the Interuniversity Attraction Poles Program P6/30
   (Belgian Science Policy).
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NR 38
TC 121
Z9 129
U1 0
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1520-7552
EI 1520-7560
J9 DIABETES-METAB RES
JI Diabetes-Metab. Res. Rev.
PD NOV
PY 2009
VL 25
IS 8
BP 733
EP 739
DI 10.1002/dmrr.1011
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 522RP
UT WOS:000272016300006
PM 19780064
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Mansego, ML
   Redon, J
   Martinez-Hervas, S
   Real, JT
   Martinez, F
   Blesa, S
   Gonzalez-Albert, V
   Saez, GT
   Carmena, R
   Chaves, FJ
AF Mansego, Maria L.
   Redon, Josep
   Martinez-Hervas, Sergio
   Real, Jose T.
   Martinez, Fernando
   Blesa, Sebastian
   Gonzalez-Albert, Veronica
   Saez, Guillermo T.
   Carmena, Rafael
   Chaves, Felipe J.
TI Different Impacts of Cardiovascular Risk Factors on Oxidative Stress
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE oxidative stress; glutathione peroxidase; superoxide dismutases; mRNA;
   hypertension; familial hypercholesterolemia; combined familial
   dyslipidemia
ID EXTRACELLULAR-SUPEROXIDE DISMUTASE; INSULIN-RESISTANCE; GENE-EXPRESSION;
   NITRIC-OXIDE; BLOOD-PRESSURE; XANTHINE OXIDOREDUCTASE;
   GLUTATHIONE-PEROXIDASE; NAD(P)H OXIDASE; PLASMA; HYPERTENSION
AB The objective of the study was to evaluate oxidative stress (OS) status in subjects with different cardiovascular risk factors. With this in mind, we have studied three models of high cardiovascular risk: hypertension (HT) with and without metabolic syndrome, familial hypercholesterolemia (FH) and familial combined hyperlipidemia (FCH) with and without insulin resistance. Oxidative stress markers (oxidized/reduced glutathione ratio, 8-oxo-deoxyguanosine and malondialdehide) together with the activity of antioxidant enzyme triad (superoxide dismutase, catalase, glutathione peroxidase) and activation of both pro-oxidant enzyme (NAPDH oxidase components) and AGTR1 genes, as well as antioxidant enzyme genes (CuZn-SOD, CAT, GPX1, GSR, GSS and TXN) were measured in mononuclear cells of controls (n = 20) and patients (n = 90) by assessing mRNA levels. Activity of some of these antioxidant enzymes was also tested. An increase in OS and pro-oxidant gene mRNA values was observed in patients compared to controls. The hypertensive group showed not only the highest OS values, but also the highest pro-oxidant activation compared to those observed in the other groups. In addition, in HT a significantly reduced antioxidant activity and mRNA induction of antioxidant genes were found when compared to controls and the other groups. In FH and FCH, the activation of pro-oxidant enzymes was also higher and antioxidant ones lower than in the control group, although it did not reach the values obtained in hypertensives. The thioredoxin system was more activated in patients as compared to controls, and the highest levels were in hypertensives. The increased oxidative status in the presence of cardiovascular risk factors is a consequence of both the activation of pro-oxidant mechanisms and the reduction of the antioxidant ones. The altered response of the main cytoplasmic antioxidant systems largely contributes to OS despite the apparent attempt of the thioredoxin system to control it.
C1 [Mansego, Maria L.; Blesa, Sebastian; Gonzalez-Albert, Veronica; Chaves, Felipe J.] Hosp Clin, Res Fdn, Genotyping & Genet Diag Unit, Valencia 46010, Spain.
   [Mansego, Maria L.; Redon, Josep; Martinez, Fernando] CIBER Obes CIBERob, Santiago De Compostela 15706, Spain.
   [Redon, Josep; Martinez, Fernando] Hosp Clin, Hypertens Unit, Valencia 46010, Spain.
   [Martinez-Hervas, Sergio; Real, Jose T.; Carmena, Rafael] Hosp Clin Univ, Serv Endocrinol & Nutr, Valencia 46010, Spain.
   [Martinez-Hervas, Sergio; Real, Jose T.; Carmena, Rafael; Chaves, Felipe J.] CIBER Diabet & Enfermedades Metab Asociadas CIBER, Barcelona 08017, Spain.
   [Saez, Guillermo T.] Univ Valencia, Dept Biochem & Mol Biol, Valencia 46010, Spain.
C3 Hospital Clinic Universitari de Valencia; CIBER - Centro de
   Investigacion Biomedica en Red; CIBERES; University of Valencia
RP Mansego, ML (corresponding author), Hosp Clin, Res Fdn, Genotyping & Genet Diag Unit, Ave Blasco Ibanez 17, Valencia 46010, Spain.
EM m.luisa.mansego@uv.es; Josep.redon@uv.es; Sergio.Martinez@uv.es;
   Jose.T.Real@uv.es; fernandoctor@hotmail.com; Sebastian.Blesa@uv.es;
   veronica.gonzalez@uv.es; Guillermo.Saez@uv.es; Rafael.Carmena@uv.es;
   felipe.chaves@uv.es
RI Redon, Josep/L-5997-2019; Blesa, Sebastián/AAC-3857-2019; CHAVES,
   FELIPE/ABC-3294-2021; Martínez, Fernando/AAO-5879-2021; Martinez Hervas,
   Sergio/K-2829-2014; MANSEGO, MARIA/A-5687-2011
OI Saez, Guillermo/0000-0002-8164-4048; CHAVES, FELIPE
   J/0000-0001-8009-3689; Martinez Hervas, Sergio/0000-0002-6775-2034;
   Blesa, Sebastian/0000-0002-5219-0796; MANSEGO,
   MARIA/0000-0001-8914-7890; Martinez Garcia,
   Fernando/0000-0001-8562-4477; Redon, Josep/0000-0001-8777-6773
FU Fondo de Investigaciones Sanitarias (F.I.S.) [PI03/0862, SAF2005-02883,
   RCMN C03/01 (RECAVA)]; Spanish Health Ministry, Valencian Government
   [GRUPOS03/101]
FX This study was supported by grants PI03/0862, SAF2005-02883 and RCMN
   C03/01 (RECAVA) of the Fondo de Investigaciones Sanitarias (F.I.S.), of
   the Spanish Health Ministry and grant GRUPOS03/101 from the Valencian
   Government. CIBER de Diabetes y Enfermedades Metabolicas Asociadas
   (CIBERDEM) and CIBER de obesidad (CIBEROB) are initiatives of the
   Instituto Carlos III, Ministerio de Ciencia e Innovacion.
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NR 77
TC 19
Z9 19
U1 0
U2 4
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD SEP
PY 2011
VL 12
IS 9
BP 6146
EP 6163
DI 10.3390/ijms12096146
PG 18
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 824PE
UT WOS:000295213600049
PM 22016650
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Saxe, GA
   Major, JM
   Westerberg, L
   Khandrika, S
   Downs, TM
AF Saxe, Gordon A.
   Major, Jacqueline M.
   Westerberg, Lindsey
   Khandrika, Srikrishna
   Downs, Tracy M.
TI Biological mediators of effect of diet and stress reduction on prostate
   cancer
SO INTEGRATIVE CANCER THERAPIES
LA English
DT Article
DE prostate; prostatic neoplasms; prostate-specific antigen; plant-based
   diet; stress reduction; sex steroid hormones; cytokines; disease
   progression
ID SEX STEROID-HORMONES; PLANT-BASED DIET; RADICAL PROSTATECTOMY;
   BIOCHEMICAL RECURRENCE; METABOLIC SYNDROME; BINDING GLOBULIN; OBESITY;
   ANTIGEN; RISK; RADIATION
AB Background. A 6-month pilot intervention trial was conducted to determine whether adoption of a plant-based diet, reinforced by stress reduction, could reduce the rate of prostate-specific antigen (PSA) increase, a marker of disease progression, in asymptomatic, hormonally untreated patients experiencing consistently increasing PSA levels after surgery or radiation. Methods. A pre-post design was used to examine (1) the effect of intervention on potential mediators of disease progression, including body composition and weight-related biomarkers (sex steroid hormones and cytokines), and (2) whether changes in these variables were associated with change in rate of PSA increase. The baseline rate of PSA increase (from the time of posttreatment recurrence to the start of intervention) was ascertained from medical records. Body composition and biomarkers were assessed at baseline (prior to intervention), during the intervention (3 months), and at the end of the intervention (6 months). Changes in body composition and biomarkers were determined and compared with rates of PSA increase over the corresponding time intervals. Results. There was a significant reduction in waist-to-hip ratio (P = .03) and increase in circulating sex hormone binding globulin (P = .04). The rate of PSA increase decreased from the preintervention period (PSA slope = 0.059) to the period from 0 to 3 months (PSA slope = 0.002, P < .01) and increased slightly, although not significantly, from 0 to 3 months to the period from 3 to 6 months (0.029, P = .43). Conclusions. Adoption of a plant-based diet and stress reduction may reduce central adiposity and improve the hormonal milieu in patients with recurrent PC. Changes in the rate of increase in PSA were in the same direction as changes in waist-to-hip ratio and opposite those of sex hormone binding globulin, raising the possibility that the effect of the intervention may have been mediated, in part, by these variables.
C1 [Saxe, Gordon A.; Downs, Tracy M.] Univ Calif San Diego, Moores UCSD Canc Ctr, La Jolla, CA 92093 USA.
   [Saxe, Gordon A.; Major, Jacqueline M.] Univ Calif San Diego, Dept Family & Prevent Med, La Jolla, CA 92093 USA.
   [Westerberg, Lindsey] Univ Calif San Diego, UCSD Sch Med, La Jolla, CA 92093 USA.
   [Khandrika, Srikrishna] Univ Calif San Diego, Dept Med Clin Res, La Jolla, CA 92093 USA.
   [Downs, Tracy M.] Univ Calif San Diego, Dept Surg, La Jolla, CA 92093 USA.
C3 University of California System; University of California San Diego;
   University of California System; University of California San Diego;
   University of California System; University of California San Diego;
   University of California System; University of California San Diego;
   University of California System; University of California San Diego
RP Saxe, GA (corresponding author), Univ Calif San Diego, Moores UCSD Canc Ctr, 385 Hlth Sci Dr 0901, La Jolla, CA 92093 USA.
EM gsaxe@ucsd.edu
FU NIH [K23 AT002965-03]; American Cancer Society [CRTG-03-073-01-PBP];
   UCSD GCRC
FX This study was supported by NIH grant 1 K23 AT002965-03, American Cancer
   Society Grant CRTG-03-073-01-PBP, and UCSD GCRC 1989. We also thank Ms.
   Eva Brzezinski, Ms. Cindy Knott, Ms. Mina Marjanovic, Ms. Aisha Menon,
   Ms. jean Richardson, Dr. Carol Salem-Hand, and Mr. Paul Shragg for their
   contributions to this study.
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NR 54
TC 22
Z9 23
U1 0
U2 5
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1534-7354
EI 1552-695X
J9 INTEGR CANCER THER
JI Integr. Cancer Ther.
PD SEP
PY 2008
VL 7
IS 3
BP 130
EP 138
DI 10.1177/1534735408322849
PG 9
WC Oncology; Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Integrative & Complementary Medicine
GA 351PQ
UT WOS:000259436800003
PM 18815144
OA gold, Green Accepted
DA 2025-06-11
ER

PT J
AU Kattoor, AJ
   Goel, A
   Mehta, JL
AF Kattoor, Ajoe John
   Goel, Akshay
   Mehta, Jawahar L.
TI LOX-1: Regulation, Signaling and Its Role in Atherosclerosis
SO ANTIOXIDANTS
LA English
DT Review
DE LOX-1; ox-LDL; atherogenesis; atherosclerosis; oxidative stress
ID LOW-DENSITY-LIPOPROTEIN; OXIDIZED LDL RECEPTOR; AORTIC
   ENDOTHELIAL-CELLS; INDUCED OXIDATIVE STRESS; SMOOTH-MUSCLE-CELLS;
   OX-LDL; UP-REGULATION; COLLAGEN ACCUMULATION; PLATELET ACTIVATION;
   SCAVENGER RECEPTORS
AB Atherosclerosis has long been known to be a chronic inflammatory disease. In addition, there is intense oxidative stress in atherosclerosis resulting from an imbalance between the excess reactive oxygen species (ROS) generation and inadequate anti-oxidant defense forces. The excess of the oxidative forces results in the conversion of low-density lipoproteins (LDL) to oxidized LDL (ox-LDL), which is highly atherogenic. The sub-endothelial deposition of ox-LDL, formation of foamy macrophages, vascular smooth muscle cell (VSMC) proliferation and migration, and deposition of collagen are central pathophysiologic steps in the formation of atherosclerotic plaque. Ox-LDL exerts its action through several different scavenger receptors, the most important of which is LOX-1 in atherogenesis. LOX-1 is a transmembrane glycoprotein that binds to and internalizes ox-LDL. This interaction results in variable downstream effects based on the cell type. In endothelial cells, there is an increased expression of cellular adhesion molecules, resulting in the increased attachment and migration of inflammatory cells to intima, followed by their differentiation into macrophages. There is also a worsening endothelial dysfunction due to the increased production of vasoconstrictors, increased ROS, and depletion of endothelial nitric oxide (NO). In the macrophages and VSMCs, ox-LDL causes further upregulation of the LOX-1 gene, modulation of calpains, macrophage migration, VSMC proliferation and foam cell formation. Soluble LOX-1 (sLOX-1), a fragment of the main LOX-1 molecule, is being investigated as a diagnostic marker because it has been shown to be present in increased quantities in patients with hypertension, diabetes, metabolic syndrome and coronary artery disease. LOX-1 gene deletion in mice and anti-LOX-1 therapy has been shown to decrease inflammation, oxidative stress and atherosclerosis. LOX-1 deletion also results in damage from ischemia, making LOX-1 a promising target of therapy for atherosclerosis and related disorders. In this article we focus on the different mechanisms for regulation, signaling and the various effects of LOX-1 in contributing to atherosclerosis.
C1 [Kattoor, Ajoe John] John H Stroger Jr Hosp Cook Cty, Div Cardiol, Chicago, IL 60612 USA.
   [Goel, Akshay; Mehta, Jawahar L.] Univ Arkansas Med Sci, Cent Arkansas Vet Healthcare Syst, Div Cardiol, Little Rock, AR 72205 USA.
C3 University of Illinois System; University of Illinois Chicago;
   University of Illinois Chicago Hospital; John H Stroger Junior Hospital
   Cook County; US Department of Veterans Affairs; Veterans Health
   Administration (VHA); Central Arkansas Veterans Healthcare System;
   University of Arkansas System; University of Arkansas Medical Sciences
RP Mehta, JL (corresponding author), Univ Arkansas Med Sci, Cent Arkansas Vet Healthcare Syst, Div Cardiol, Little Rock, AR 72205 USA.
EM MehtaJL@uams.edu
RI Goel, Akshay/ABD-2916-2021; Mehta, jl/AAB-8832-2019; Kattoor,
   Ajoe/X-9313-2019
OI Goel, Akshay/0000-0003-4517-4197; Mehta, jl/0000-0003-0384-2097
FU United States Department of Veterans Affairs Biomedical Laboratory
   Research and Development Service [BX000282-09A2]
FX This work was supported by Award # BX000282-09A2 from the United States
   Department of Veterans Affairs Biomedical Laboratory Research and
   Development Service.
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NR 99
TC 190
Z9 199
U1 5
U2 29
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD JUL
PY 2019
VL 8
IS 7
AR 218
DI 10.3390/antiox8070218
PG 15
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA IN3XB
UT WOS:000478608600025
PM 31336709
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Triest, FJJ
   Franssen, FME
   Reynaert, N
   Gaffron, S
   Spruit, MA
   Janssen, DJA
   Rutten, EPA
   Wouters, EFM
   Vanfleteren, LEGW
AF Triest, Filip J. J.
   Franssen, Frits M. E.
   Reynaert, Niki
   Gaffron, Swetlana
   Spruit, Martijn A.
   Janssen, Daisy J. A.
   Rutten, Erica P. A.
   Wouters, Emiel F. M.
   Vanfleteren, Lowie E. G. W.
TI Disease-Specific Comorbidity Clusters in COPD and Accelerated Aging
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Article
DE comorbidity; multimorbidity; cluster; COPD; accelerated aging; telomere
   length
ID OBSTRUCTIVE PULMONARY-DISEASE; BODY-MASS INDEX; TELOMERE LENGTH;
   ARTERIAL STIFFNESS; CIRCULATING LEUKOCYTES; CARDIOVASCULAR-DISEASE;
   SYSTEMIC INFLAMMATION; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   DEPRESSION
AB Background: Patients with chronic obstructive pulmonary disease (COPD) often suffer from multiple morbidities, which occur in clusters and are sometimes related to accelerated aging. This study aimed to assess the disease specificity of comorbidity clusters in COPD and their association with a biomarker of accelerated aging as a potential mechanistic factor. Methods: Body composition, metabolic, cardiovascular, musculoskeletal, and psychological morbidities were objectively evaluated in 208 COPD patients (age 62 +/- 7 years, 58% males, FEV1 50 +/- 16% predicted) and 200 non-COPD controls (age 61 +/- 7 years, 45% males). Based on their presence and severity, the morbidities were clustered to generate distinct clusters in COPD and controls. Telomere length in circulating leukocytes was compared across the clusters. Results: (co)morbidities were more prevalent in COPD patients compared to controls (3.9 +/- 1.7 vs. 2.4 +/- 1.5, p < 0.05). A Psychologic and Cachectic cluster were only present in the COPD population. Less (co)morbidity, Cardiovascular, and Metabolic clusters were also observed in controls, although with less complexity. Telomere length was reduced in COPD patients, but did not differ between the (co)morbidity clusters in both populations. Conclusions: Two COPD-specific comorbidity clusters, a Cachectic and Psychologic cluster, were identified and warrant further studies regarding their development. Accelerated aging was present across various multimorbidity clusters in COPD.
C1 [Triest, Filip J. J.; Franssen, Frits M. E.; Spruit, Martijn A.; Janssen, Daisy J. A.; Rutten, Erica P. A.; Wouters, Emiel F. M.; Vanfleteren, Lowie E. G. W.] Ctr Expertise Chron Organ Failure, CIRO, NL-6085 NM Horn, Netherlands.
   [Triest, Filip J. J.; Franssen, Frits M. E.; Reynaert, Niki; Spruit, Martijn A.; Wouters, Emiel F. M.; Vanfleteren, Lowie E. G. W.] MUMC, Dept Resp Med, NL-6229 ER Maastricht, Netherlands.
   [Triest, Filip J. J.] AZ Sint Lucas, Dept Resp Med, B-9000 Ghent, Belgium.
   [Franssen, Frits M. E.; Spruit, Martijn A.] Maastricht Univ Med Ctr, NUTRIM Sch Nutr & Translat Res Metab, NL-6229 ER Maastricht, Netherlands.
   [Gaffron, Swetlana] Viscovery Software GmbH, A-1130 Vienna, Austria.
C3 Maastricht University; Maastricht University; Maastricht University
   Medical Centre (MUMC)
RP Vanfleteren, LEGW (corresponding author), Ctr Expertise Chron Organ Failure, CIRO, NL-6085 NM Horn, Netherlands.; Vanfleteren, LEGW (corresponding author), MUMC, Dept Resp Med, NL-6229 ER Maastricht, Netherlands.
EM filiptriest@hotmail.com; fritsfranssen@ciro-horn.nl;
   n.reynaert@maastrichtuniversity.nl; s.gaffron@viscovery.net;
   martijnspruit@ciro-horn.nl; daisyjanssen@ciro-horn.nl;
   ericarutten07@gmail.com; e.wouters@mumc.nl;
   lowievanfleteren@ciro-horn.nl
RI Spruit, Martijn/NES-5959-2025; Vanfleteren, Lowie/AFP-7937-2022;
   Janssen, Daisy/AAW-2248-2021; Reynaert, Niki/C-5491-2014; Wouters,
   Emiel/ABD-6200-2021; Franssen, Frits M.E./B-6988-2018
OI Franssen, Frits M.E./0000-0002-1633-6356; Reynaert,
   Niki/0000-0002-8577-8094; Janssen, Daisy/0000-0002-1827-9869; Gaffron,
   Swetlana/0000-0002-4540-0732
FU Lung Foundation Netherlands, previously Dutch Asthma Foundation
   [3.2.09.049]; Weijerhorst Foundation
FX This research was partly funded by the Lung Foundation Netherlands,
   previously Dutch Asthma Foundation, grant number 3.2.09.049 and an
   unrestricted grant from the Weijerhorst Foundation.
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NR 56
TC 32
Z9 32
U1 1
U2 2
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD APR
PY 2019
VL 8
IS 4
AR 511
DI 10.3390/jcm8040511
PG 18
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA HX6FT
UT WOS:000467500200096
PM 31013986
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Gerdes, S
   Zahl, VA
   Knopf, H
   Weichenthal, M
   Mrowietz, U
AF Gerdes, S.
   Zahl, V. A.
   Knopf, H.
   Weichenthal, M.
   Mrowietz, U.
TI Comedication related to comorbidities: a study in 1203 hospitalized
   patients with severe psoriasis
SO BRITISH JOURNAL OF DERMATOLOGY
LA English
DT Article
DE comedication; comorbidities; psoriasis
ID GENERAL-POPULATION; RISK; DISEASE; DEPRESSION; PREVALENCE; VULGARIS;
   THERAPY; DRUGS
AB Background Psoriasis is a common dermatological disorder characterized by an immune-mediated chronic inflammation which is associated with a variety of other diseases commonly referred to as comorbidities. The treatments for these diseases may interfere with the course and the treatment of psoriasis. Little is known on the general drug intake of patients with psoriasis.
   Objectives To gain more insight into the general drug intake of patients with severe psoriasis. A correlation of comedication to respective diseases could lead to a better knowledge of comorbidities.
   Methods Data on demographics, comedication and comorbidities from 1203 patients with severe psoriasis in Germany were analysed. As a control group data from 7099 subjects from the German National Health Survey 1998 were used.
   Results Patients with severe psoriasis are receiving significantly more different systemic drugs on average than the general population, with the most prominent difference in multidrug treatment. Drugs used in the treatment of arterial hypertension, diabetes mellitus and other diseases of the metabolic syndrome as well as oral anticoagulants and anticonvulsant agents showed the greatest differences. Special characteristics of antihypertensive drug treatments could be determined.
   Conclusions The data obtained in this study provide the basis for an improved management of patients with psoriasis. Knowledge of existing comedication and comorbidities may lead to the ability to treat psoriasis and comorbidities at the same time more safely and to use possible synergistic effects.
C1 [Gerdes, S.; Zahl, V. A.; Weichenthal, M.; Mrowietz, U.] Univ Clin Schleswig Holstein, Dept Dermatol, Psoriasis Ctr, D-24105 Kiel, Germany.
   [Knopf, H.] Robert Koch Inst, D-1000 Berlin, Germany.
C3 University of Kiel; Schleswig Holstein University Hospital; Robert Koch
   Institute
RP Gerdes, S (corresponding author), Univ Clin Schleswig Holstein, Dept Dermatol, Psoriasis Ctr, Campus Kiel, D-24105 Kiel, Germany.
EM sgerdes@dermatology.uni-kiel.de
RI Weichenthal, Michael/A-5692-2009; mrowietz, ulrich/B-1645-2010; Gerdes,
   Sascha/J-4308-2017
OI mrowietz, ulrich/0000-0002-9539-0712; Gerdes,
   Sascha/0000-0002-6667-7757; Weichenthal, Michael/0000-0002-9060-4961
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NR 26
TC 64
Z9 68
U1 0
U2 1
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0007-0963
J9 BRIT J DERMATOL
JI Br. J. Dermatol.
PD NOV
PY 2008
VL 159
IS 5
BP 1116
EP 1123
DI 10.1111/j.1365-2133.2008.08786.x
PG 8
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 362FS
UT WOS:000260184200008
PM 18717681
DA 2025-06-11
ER

PT J
AU Subhashri, S
   Pal, P
   Pal, GK
   Papa, D
   Nanda, N
AF Subhashri, Soundirarajan
   Pal, Pravati
   Pal, Gopal Krushna
   Papa, Dasari
   Nanda, Nivedita
TI Decreased baroreflex sensitivity is associated with cardiometabolic
   risks and prehypertension status in early-postmenopausal women
SO CLINICAL AND EXPERIMENTAL HYPERTENSION
LA English
DT Article
DE Cardiovascular risk; baroreflex sensitivity; prehypertension status;
   early-postmenopausal women; sympathovagal imbalance
ID HEART-RATE-VARIABILITY; OBESITY; PLASMA; YOUNG
AB Objective We studied the link of decreased baroreflex sensitivity (BRS) to cardiometabolic risks and prehypertension status in postmenopausal women during their early menopausal phase. Methods Premenopausal women (n= 55) and early-postmenopausal women (n= 50) of age group between 40 and 55 years were recruited for the study, and their anthropometric parameters, complete battery of autonomic function tests (AFT), BRS, hormone levels, and cardiometabolic risk parameters were measured and compared between two groups. Correlation analysis of BRS with various physiological and biochemical parameters in these two groups were performed. Multiple regression analysis of BRS with various other associated factors in postmenopausal subjects and bivariate logistic regression analysis for assessing prediction of prehypertension status by BRS in postmenopausal group were performed. Results There was a significant difference in AFT and metabolic parameters between premenopausal and postmenopausal women. Sympathovagal imbalance (increased sympathetic and decreased parasympathetic) was prominent in early-postmenopausal women. Decreased BRS, the marker of cardiovascular (CV) risk was found to be significant (P< .001) and correlated with various cardiometabolic parameters in early-postmenopausal subjects. Multiple regression analysis demonstrated that decreased BRS is independently linked to parameters of decreased vagal activity, inflammation, and oxidative stress in early-postmenopausal group. Decreased BRS could predict prehypertension status in early-postmenopausal subjects as confirmed by bivariate logistic regression analysis. Conclusion Sympathovagal imbalance, decreased BRS and considerable metabolic derangements were observed in women in their early phase of menopause. Decreased BRS appears to be associated with the cardiometabolic risks in these women. Prehypertension status in early-postmenopausal subjects could be predicted by decreased BRS.
C1 [Subhashri, Soundirarajan; Pal, Pravati; Pal, Gopal Krushna] JIPMER, Dept Physiol, Pondicherry 605006, India.
   [Papa, Dasari] JIPMER, Dept Obstet & Gynaecol, Pondicherry, India.
   [Nanda, Nivedita] JIPMER, Dept Biochem, Pondicherry, India.
   [Subhashri, Soundirarajan] Bhaarath Med Coll & Hosp, Chennai, Tamil Nadu, India.
C3 Jawaharlal Institute of Postgraduate Medical Education & Research;
   Jawaharlal Institute of Postgraduate Medical Education & Research;
   Jawaharlal Institute of Postgraduate Medical Education & Research
RP Pal, GK (corresponding author), JIPMER, Dept Physiol, Pondicherry 605006, India.
EM drgkpal@gmail.com
RI Nanda, Nivedita/P-6453-2014; Pal, Pravati/IUQ-5179-2023
OI Pal, Pravati/0009-0003-4061-0241
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NR 45
TC 5
Z9 5
U1 0
U2 3
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1064-1963
EI 1525-6006
J9 CLIN EXP HYPERTENS
JI Clin. Exp. Hypertens.
PD FEB 17
PY 2021
VL 43
IS 2
BP 112
EP 119
DI 10.1080/10641963.2020.1817475
EA SEP 2020
PG 8
WC Pharmacology & Pharmacy; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Cardiovascular System & Cardiology
GA PO7MV
UT WOS:000567197000001
PM 32896167
DA 2025-06-11
ER

PT J
AU Crane, JD
   Joy, G
   Knott, KD
   Augusto, JB
   Lau, C
   Bhuva, AN
   Seraphim, A
   Evain, T
   Brown, LAE
   Chowdhary, A
   Kotecha, T
   Fontana, M
   Plein, S
   Ramar, S
   Rubino, F
   Kellman, P
   Xue, H
   Pierce, I
   Davies, RH
   Moon, JC
   Cruickshank, JK
   McGowan, BM
   Manisty, C
AF Crane, James D.
   Joy, George
   Knott, Kristopher D.
   Augusto, Joao B.
   Lau, Clement
   Bhuva, Anish N.
   Seraphim, Andreas
   Evain, Timothee
   Brown, Louise A. E.
   Chowdhary, Amrit
   Kotecha, Tushar
   Fontana, Marianna
   Plein, Sven
   Ramar, Sasindran
   Rubino, Francesco
   Kellman, Peter
   Xue, Hui
   Pierce, Iain
   Davies, Rhodri H.
   Moon, James C.
   Cruickshank, J. Kennedy
   McGowan, Barbara M.
   Manisty, Charlotte
TI The Impact of Bariatric Surgery on Coronary Microvascular Function
   Assessed Using Automated Quantitative Perfusion CMR
SO JACC-CARDIOVASCULAR IMAGING
LA English
DT Article
DE bariatric surgery; coronary microvascular function; obesity;
   quantitative perfusion CMR
ID WEIGHT-LOSS; CARDIAC STRUCTURE; HEART-FAILURE; DYSFUNCTION;
   ENDOCANNABINOIDS; INDIVIDUALS; OBESITY; RISK
AB Background Coronary microvascular function is impaired in patients with obesity, contributing to myocardial dysfunction and heart failure. Bariatric surgery decreases cardiovascular mortality and heart failure, but the mechanisms are unclear. Objectives The authors studied the impact of bariatric surgery on coronary microvascular function in patients with obesity and its relationship with metabolic syndrome. Methods Fully automated quantitative perfusion cardiac magnetic resonance and metabolic markers were performed before and 6 months after bariatric surgery. Results Compared with age- and sex-matched healthy volunteers, 38 patients living with obesity had lower stress myocardial blood flow (MBF) (P = 0.001) and lower myocardial perfusion reserve (P < 0.001). A total of 27 participants underwent paired follow-up 6 months post-surgery. Metabolic abnormalities reduced significantly at follow-up including mean body mass index by 11 +/- 3 kg/m(2) (P < 0.001), glycated hemoglobin by 9 mmol/mol (Q1-Q3: 4-19 mmol/mol; P < 0.001), fasting insulin by 142 +/- 131 pmol/L (P < 0.001), and hepatic fat fraction by 5.6% (Q1-Q3: 2.6%-15.0%; P < 0.001). Stress MBF increased by 0.28 mL/g/min (Q1-Q3: -0.02 to 0.75 mL/g/min; P = 0.003) and myocardial perfusion reserve by 0.13 (Q1-Q3: -0.25 to 1.10; P = 0.036). The increase in stress MBF was lower in those with preoperative type 2 diabetes mellitus (0.1 mL/g/min [Q1-Q3: -0.09 to 0.46 mL/g/min] vs 0.75 mL/g/min [Q1-Q3: 0.31-1.25 mL/g/min]; P = 0.002). Improvement in stress MBF was associated with reduction in fasting insulin (beta = -0.45 [95% CI: -0.05 to 0.90]; P = 0.03). Conclusions Coronary microvascular function is impaired in patients with obesity, but can be improved significantly with bariatric surgery. Improvements in microvascular function are associated with improvements in insulin resistance but are attenuated in those with preoperative type 2 diabetes mellitus.
C1 [Crane, James D.; Cruickshank, J. Kennedy; McGowan, Barbara M.] Kings Coll London, Sch Life Course Sci, London, England.
   [Crane, James D.; Ramar, Sasindran; Rubino, Francesco] Kings Coll Hosp NHS Fdn Trust, London, England.
   [Joy, George; Bhuva, Anish N.; Pierce, Iain; Davies, Rhodri H.; Moon, James C.; Manisty, Charlotte] Barts Hlth NHS Trust, Barts Heart Ctr, London, England.
   [Joy, George; Knott, Kristopher D.; Augusto, Joao B.; Bhuva, Anish N.; Seraphim, Andreas; Kotecha, Tushar; Fontana, Marianna; Pierce, Iain; Davies, Rhodri H.; Moon, James C.; Manisty, Charlotte] UCL, Inst Cardiovasc Sci, Roger Williams Bldg,69-75 Chenies Mews, London WC1E 6HX, England.
   [Lau, Clement] Queen Mary Univ London, William Harvey Res Inst, London, England.
   [Evain, Timothee] Imageens, Paris, France.
   [Brown, Louise A. E.; Plein, Sven] Univ Leeds, Leeds Inst Cardiovasc & Metab Med, Leeds, England.
   [Kotecha, Tushar; Fontana, Marianna] Royal Free London NHS Fdn Trust London, Dept Cardiol, London, England.
   [Kellman, Peter; Xue, Hui] NHLBI, NIH, Bethesda, MD USA.
   [Pierce, Iain; Davies, Rhodri H.] UCL, Med Res Council Unit Lifelong Hlth & Ageing, London, England.
   [Cruickshank, J. Kennedy; McGowan, Barbara M.] Guys & St Thomas NHS Fdn Trust, Dept Diabet & Endocrinol, London, England.
C3 University of London; King's College London; King's College Hospital NHS
   Foundation Trust; Barts Health NHS Trust; University of London;
   University College London; University of London; Queen Mary University
   London; University of Leeds; National Institutes of Health (NIH) - USA;
   NIH National Heart Lung & Blood Institute (NHLBI); University of London;
   University College London; UK Research & Innovation (UKRI); Medical
   Research Council UK (MRC); Guy's & St Thomas' NHS Foundation Trust
RP Manisty, C (corresponding author), Barts Hlth NHS Trust, Barts Heart Ctr, London, England.; Manisty, C (corresponding author), UCL, Inst Cardiovasc Sci, Roger Williams Bldg,69-75 Chenies Mews, London WC1E 6HX, England.
EM c.manisty@ucl.ac.uk
RI Augusto, João/W-8208-2019; Plein, Sven/LRT-1077-2024; Manisty,
   Charlotte/AAN-3723-2021; Fontana, Marianna/ADU-3327-2022; Moon,
   James/F-1031-2014
OI Bhuva, Anish/0000-0001-7532-7815; Augusto, Joao/0000-0003-0040-5270;
   Davies, Rhodri/0000-0001-7630-7517; Chowdhary,
   Amrit/0000-0002-2073-4138; Brown, Louise Anne
   Elizabeth/0000-0002-1327-6482; Joy, George/0000-0003-1467-5490
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NR 40
TC 6
Z9 6
U1 1
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1936-878X
EI 1876-7591
J9 JACC-CARDIOVASC IMAG
JI JACC-Cardiovasc. Imag.
PD NOV
PY 2024
VL 17
IS 11
BP 1305
EP 1316
DI 10.1016/j.jcmg.2024.05.022
EA NOV 2024
PG 12
WC Cardiac & Cardiovascular Systems; Radiology, Nuclear Medicine & Medical
   Imaging
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Radiology, Nuclear Medicine &
   Medical Imaging
GA L6Y5S
UT WOS:001352154000001
PM 39115498
DA 2025-06-11
ER

PT J
AU Alsuwayt, B
   Iftikhar, N
   Hussain, AI
   Ahmad, A
   Zafar, I
   Khanam, A
   Tan, WN
   Nahar, L
   Almuqati, AF
   Haji, EM
   Almutairy, AF
   Sarker, SD
AF Alsuwayt, Bader
   Iftikhar, Neelam
   Hussain, Abdullah Ijaz
   Ahmad, Ashfaq
   Zafar, Irsa
   Khanam, Arifa
   Tan, Wen-Nee
   Nahar, Lutfun
   Almuqati, Afaf F.
   Haji, Esraa Mohammad
   Almutairy, Ali F.
   Sarker, Satyajit D.
TI The Bioprotective Effects of Marigold Tea Polyphenols on Obesity and
   Oxidative Stress Biomarkers in High-Fat-Sugar Diet-Fed Rats
SO CARDIOVASCULAR THERAPEUTICS
LA English
DT Article
DE lipid profile; marigold petal tea; obesity; oxidative stress; rutin
ID SERUM BILIRUBIN LEVELS; ANTIMICROBIAL ACTIVITIES; CALENDULA-OFFICINALIS;
   ZINGIBER-OFFICINALE; METABOLIC SYNDROME; ANTIOXIDANT; L.; EXTRACTS;
   PROFILE; LIPASE
AB Background: The research is aimed at exploring the potential of marigold petal tea (MPT), rich in polyphenol contents, against oxidative stress and obesity in a rat model following a high-fat-sugar diet (HFSD).Methods: The MPT was prepared through the customary method of decoction and was subjected to analysis for its polyphenol composition using reversed-phase high-performance liquid chromatography (RP-HPLC). Two specific doses of MPT, namely, 250 and 500 mg/kg body weight (BW), were chosen for the study-referred to as MPT-250 and MPT-500, respectively.Result: The main phenolic acids and flavonoids identified in MPT, with concentrations exceeding 10 mg/100 mL of tea, included catechin, rutin, salicylic acid, gallic acid, sinapic acid, chlorogenic acid, cinnamic acid, and ellagic acid. The total phenolic (TP) and total flavonoid (TF) contents in MPT were measured to be 5.53 and 7.73 mg/g, respectively. Additionally, MPT demonstrated a 57.2% scavenging capacity with 2,2-diphenyl-1-picrylhydrazyl radical. Notably, the administration of a higher dose (MPT-500) showed a significant reduction in body mass index (BMI) and a 51.24% reduction in the rate of increase in BW compared to the HFSD group. The findings indicated that all the treatment groups, that is, orlistat treatment (OT), MPT-250, and MPT-500 groups, experienced reduced levels of serum total cholesterol (TC), triglyceride (TG), and markers of lipoproteins in contrast to the HFSD group. Moreover, MPT helped restore the levels of malondialdehyde (MDA), superoxide dismutase (SOD), and reduced glutathione (GSH), thereby demonstrating its potential in combating oxidative stress. The MPT-500 group also displayed decreased liver and kidney weights and an improved atherogenic index when compared to the HFSD group.Conclusion: The results clearly indicate that a high dosage of MPT showed antiobesity activity which was comparable to the same effects produced by the conventional drug orlistat.
C1 [Alsuwayt, Bader; Ahmad, Ashfaq] Univ Hafr Al Batin, Coll Pharm, Dept Pharm Practice, Hafar Al Batin 39524, Saudi Arabia.
   [Iftikhar, Neelam; Hussain, Abdullah Ijaz; Zafar, Irsa; Khanam, Arifa] Govt Coll Univ Faisalabad, Dept Chem, Faisalabad 38000, Pakistan.
   [Tan, Wen-Nee] Univ Sains Malaysia, Sch Distance Educ, Chem Sect, Gelugor 11800, Penang, Malaysia.
   [Nahar, Lutfun] Inst Expt Bot ASCR, Lab Growth Regulators, Slechtitelu 27, Olomouc 78371, Czech Republic.
   [Nahar, Lutfun] Palacky Univ, Slechtitelu 27, Olomouc 78371, Czech Republic.
   [Almuqati, Afaf F.; Haji, Esraa Mohammad] Univ Hafr Al Batin, Coll Pharm, Dept Pharmaceut Chem, Hafar Al Batin 39524, Saudi Arabia.
   [Almutairy, Ali F.] Qassim Univ, Coll Pharm, Dept Pharmacol & Toxicol, Buraydah 51452, Saudi Arabia.
   [Sarker, Satyajit D.] Liverpool John Moores Univ, Sch Pharm & Biomol Sci, Ctr Nat Prod Discovery, James Parsons Bldg,Byrom St, Liverpool L3 3AF, England.
C3 Hafr Albatin University; Government College University Faisalabad;
   Universiti Sains Malaysia; Czech Academy of Sciences; Institute of
   Experimental Botany of the Czech Academy of Sciences; Palacky University
   Olomouc; Hafr Albatin University; Qassim University; Liverpool John
   Moores University
RP Ahmad, A (corresponding author), Univ Hafr Al Batin, Coll Pharm, Dept Pharm Practice, Hafar Al Batin 39524, Saudi Arabia.; Hussain, AI (corresponding author), Govt Coll Univ Faisalabad, Dept Chem, Faisalabad 38000, Pakistan.
EM balsuwayt@uhb.edu.sa; nelamiftikhar26@yahoo.com;
   abdullahijaz@gcuf.edu.pk; ashfaqa@uhb.edu.sa; irsazafar3600@gmail.com;
   arifakhanam007@gmail.com; tanwn@usm.my; drnahar@live.co.uk;
   aalmaqati@uhb.edu.sa; emhaji@uhb.edu.sa; a.almotairi@qu.edu.sa;
   s.sarker@ljmu.ac.uk
RI Haji, Esraa/LNP-8890-2024; Hussain, Abdullah/AGI-0192-2022; Tan,
   Wen-Nee/A-2201-2016; Alsuwayt, Bader/HSG-7114-2023; Sarker,
   Satyajit/ABC-6278-2021; Ahmad, Ashfaq/GQV-4782-2022; Almuqati,
   Afaf/HSG-9056-2023
OI Almutairy, Ali/0009-0007-7954-4893; Hussain, Abdullah
   Ijaz/0000-0001-7862-8859; Ahmad, Ashfaq/0000-0002-9185-4639; Sarker,
   Satyajit/0000-0003-4038-0514; Almuqati, Afaf/0000-0002-4361-6791;
   Alsuwayt, Bader/0000-0002-3435-7994
FU GCUF, Faisalabad, Pakistan
FX The services provided by the Central Hi-Tech Lab, GCUF, Faisalabad,
   Pakistan, for the characterization of compounds are greatly
   acknowledged.
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NR 49
TC 2
Z9 2
U1 7
U2 11
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1755-5914
EI 1755-5922
J9 CARDIOVASC THER
JI Cardiovasc. Ther.
PD OCT 4
PY 2024
VL 2024
AR 3833521
DI 10.1155/2024/3833521
PG 10
WC Cardiac & Cardiovascular Systems; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Pharmacology & Pharmacy
GA I4Y8G
UT WOS:001330336000001
PM 39742004
OA gold
DA 2025-06-11
ER

PT J
AU Antwi, J
   Appiah, B
   Oluwakuse, B
   Abu, BAZ
AF Antwi, Janet
   Appiah, Bernard
   Oluwakuse, Busayo
   Abu, Brenda A. Z.
TI The Nutrition-COVID-19 Interplay: a Review
SO CURRENT NUTRITION REPORTS
LA English
DT Review
DE Nutrition; COVID-19; Immune system; Double burden of malnutrition;
   Nutrition behavior; Weight changes; Food insecurity; Ageusia; Dysgeusia;
   Lockdown
ID FOOD INSECURITY; COVID-19; MALNUTRITION; ADULTS; OBESITY; TASTE
AB Purpose of Review Nutritional status is affected by the COVID-19 pandemic, directly or indirectly. Even with the recent rollout of the coronavirus disease 2019 (COVID-19) vaccines and availability of medicines such as remdesivir, and monoclonal antibodies, host nutritional status is pivotal in the fight against the acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and outcomes. The purpose of this review is to discuss the effects of COVID-19-related lockdown on lifestyle behaviors, and the nutritional consequences, and the direct sequelae of the infection on nutrition including potential nutritional interventions. Recent Findings The COVID-19-related lockdown imposed radical changes in lifestyle behaviors with considerable short-term and long-term health and nutritional consequences including weight gain and obesity and increased cardiometabolic risk, consistently linked to worsened prognosis. The extent of the impact was dependent on food insecurity, overall stress and disordered eating, physical inactivity, and exposure to COVID-19-related nutrition information sources. COVID-19 could directly induce inflammatory responses and poor nutrient intake and absorption leading to undernutrition with micronutrient deficiencies, which impairs immune system function with subsequent amplified risk of infection and disease severity. Nutrition interventions through nutrition support, dietary supplementation, and home remedies such as use of zinc, selenium, vitamin D, and omega-3 fatty acids showed the most significant promise to mitigate the course of COVID-19 infection and improve survival rates. The nutrition-COVID-19 relationship and related dietary changes mimic a vicious cycle of the double burden of malnutrition, both obesity and undernutrition with micronutrient deficiencies, which promote infection, disease progression, and potential death.
C1 [Antwi, Janet; Oluwakuse, Busayo] Prairie View A&M Univ, Dept Agr Nutr & Human Ecol, Prairie View, TX 77446 USA.
   [Appiah, Bernard] Syracuse Univ, Dept Publ Hlth, Syracuse, NY USA.
   [Abu, Brenda A. Z.] Coll Hlth Sci & Technol, Wegmans Sch Hlth & Nutr, Rochester, NY USA.
C3 Texas A&M University System; Prairie View A&M University; Syracuse
   University
RP Antwi, J (corresponding author), Prairie View A&M Univ, Dept Agr Nutr & Human Ecol, Prairie View, TX 77446 USA.
EM jaantwi@pvamu.edu
RI Appiah, Bernard/HKN-0925-2023; Abu, Brenda/AAE-5674-2021
OI Antwi, Janet/0000-0002-8270-7717; Appiah, Bernard/0000-0002-5473-3459
FU Cooperative Agriculture Research Center of the College of Agriculture
   and Human Sciences at Prairie View AM University
FX The authors would like to thank the Cooperative Agriculture Research
   Center of the College of Agriculture and Human Sciences at Prairie View
   A&M University for supporting cost of publication of this work.
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NR 93
TC 47
Z9 47
U1 2
U2 42
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
EI 2161-3311
J9 CURR NUTR REP
JI Curr. Nutr. Rep.
PD DEC
PY 2021
VL 10
IS 4
BP 364
EP 374
DI 10.1007/s13668-021-00380-2
EA NOV 2021
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nutrition & Dietetics
GA XY1DS
UT WOS:000722954700001
PM 34837637
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Machado, IBS
   Tofanelli, MR
   da Silva, AAS
   Silva, ACSE
AF Machado, Isabella Barreto S.
   Tofanelli, Matheus Rampinelli
   Saldanha da Silva, Ariadna A.
   Simoes e Silva, Ana Cristina
TI Factors Associated with Primary Hypertension in Pediatric Patients: An
   Up-to-Date
SO CURRENT PEDIATRIC REVIEWS
LA English
DT Review
DE Primary hypertension; pediatrics; arterial hypertension; genetic
   factors; environmental factors; risk factors; blood pressure;
   cardiovascular diseases
ID LOW-BIRTH-WEIGHT; HIGH BLOOD-PRESSURE; CARDIOMETABOLIC RISK-FACTORS;
   PRENATAL METHYLMERCURY EXPOSURE; OBESITY-RELATED HYPERTENSION; VIGOROUS
   PHYSICAL-ACTIVITY; GENOME-WIDE ASSOCIATION; EARLY-LIFE STRESS; BODY-MASS
   INDEX; SOCIOECONOMIC-STATUS
AB Background: Arterial hypertension in children is considered a common alteration nowadays, mainly because obesity is a growing worldwide problem closely related to increased blood pressure. Childhood hypertension can be classified as primary or secondary, depending on the etiology. Primary or essential hypertension still has its pathophysiology not fully elucidated, and there is no consensus in the literature on most underlying mechanisms. In this review, genetic and environmental factors, including sodium and potassium intake, socioeconomic status, ethnicity, family structure, obesity, sedentary lifestyle, prematurity and low birth weight, prenatal and postnatal exposures are highlighted.
   Objective: The present study aimed to perform an update on primary hypertension in childhood, providing clinicians and researchers an overview of the current state of the literature regarding the influence of genetic and environmental factors.
   Methods: This integrative review searched for articles on genetic and environmental factors related to primary hypertension in pediatric patients. The databases evaluated were PubMed and Scopus.
   Results: The studies have provided insights regarding many genetic and environmental factors, in addition to their association with the pathophysiology of primary hypertension in childhood. Findings corroborated the idea that primary hypertension is a multifactorial disease. Further studies in the pediatric population are needed to elucidate the underlying mechanisms.
   Conclusion: The study of primary hypertension in pediatrics has utmost importance for the adoption of preventive measures and the development of more efficient treatments, therefore reducing childhood morbidity and the incidence of cardiovascular diseases and other health consequences later in life.
C1 [Machado, Isabella Barreto S.; Tofanelli, Matheus Rampinelli; Saldanha da Silva, Ariadna A.; Simoes e Silva, Ana Cristina] Fed Univ Minas Gerais UFMG, Fac Med, Interdisciplinary Lab Med Invest, Belo Horizonte, MG, Brazil.
C3 Universidade Federal de Minas Gerais
RP Silva, ACSE (corresponding author), Fed Univ Minas Gerais UFMG, Fac Med, Interdisciplinary Lab Med Invest, Belo Horizonte, MG, Brazil.
EM acssilva@hotmail.com
RI Mota, Ana/JBS-4609-2023; Simoes e Silva, Ana Cristina/A-4409-2013
OI Simoes e Silva, Ana Cristina/0000-0001-9222-3882; Barreto de Souza
   Machado, Isabella/0000-0003-1494-7994; Andrade Saldanha da Silva,
   Ariadna/0000-0003-2538-4509; Rampinelli Tofanelli,
   Matheus/0000-0003-3687-2639
FU Brazilian National Council of Research Development (CPNq)
   [302153/2019-5]; Coordination of High Education Level Personnel (CAPES)
   [002345/2019]; Foundation of Research of Minas Gerais (FAPEMIG) [CDS
   -APQ-02541-17]
FX This work was partially supported by Brazilian National Council of
   Research Development (CPNq -Grant #302153/2019-5), Coordination of High
   Education Level Personnel (CAPES -Grant #002345/2019), and Foundation of
   Research of Minas Gerais (FAPEMIG -CDS -APQ-02541-17).
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EI 1875-6336
J9 CURR PEDIATR REV
JI Curr. Pediatr. Rev.
PY 2021
VL 17
IS 1
BP 15
EP 37
DI 10.2174/1573396317999210111200222
PG 23
WC Pediatrics
WE Emerging Sources Citation Index (ESCI)
SC Pediatrics
GA RI8XN
UT WOS:000637189500003
PM 33430749
DA 2025-06-11
ER

PT J
AU Perkkiö, Y
   Auvinen, J
   Timonen, M
   Jokelainen, J
   Valkeapää, N
   Koiranen, M
   Saltevo, J
   Keinänen-Kiukaanniemi, S
AF Perkkio, Yrjo
   Auvinen, Juha
   Timonen, Markku
   Jokelainen, Jari
   Valkeapaa, Nihkolas
   Koiranen, Markku
   Saltevo, Juha
   Keinanen-Kiukaanniemi, Sirkka
TI Factors predicting 31-year survival among a population cohort in
   Northern Finland
SO INTERNATIONAL JOURNAL OF CIRCUMPOLAR HEALTH
LA English
DT Article
DE Mortality; risk factors predicting death; causes-of-death
ID METABOLIC SYNDROME; MORTALITY; SMOKING
AB We evaluated the survival of a subarctic population and the significance of traditional risk factors for mortality, causes of death and their seasonal variation from the period of 1984-2014. By the end of 2014 (follow-up), 644 (34.4% from 1,869) participants had died (42.1% of cardiovascular causes, 22.4% of neoplastic diseases). The average age at death +/- SD was 74.6 +/- 11.4 years for women (n=284) and 70.2 +/- 12.0 years for men (n=360). After adjusting for baseline age, the major risk factors predicting death were male sex (hazard ratio [HR] 1.80; 95% confidence interval [CI] 1.54-2.10), current smoking (HR 1.85; 95% CI 1.58-2.17), obesity (HR 1.75; 95% CI 1.45-2.12), high blood pressure (HR 1.46; 95% CI 1.24-1.72), cardiovascular disease (HR 1.62; 95% CI 1.36-1.93) and depression (HR 1.61; 95% CI 1.21-2.14) at baseline.
   The most common causes of death and the main risk factors predicting death in this population were the same as reported globally. Lifestyle factors had an important impact in predicting survival. The most common causes of death were the same for men and women. There was no significant difference in overall mortality rate between winter and summer, but cerebrovascular and pulmonary causes of death were more common during winter.
C1 [Perkkio, Yrjo; Auvinen, Juha; Timonen, Markku; Koiranen, Markku; Keinanen-Kiukaanniemi, Sirkka] Univ Oulu, Fac Med, Ctr Life Course Hlth Res, Oulu, Finland.
   [Perkkio, Yrjo] Hlth Ctr Muonio Enontekio, Lapland Cent Hosp, Dept Primary Hlth Care, Rovaniemi, Finland.
   [Auvinen, Juha] Hlth Ctr Oulunkaari, Ii, Finland.
   [Timonen, Markku; Jokelainen, Jari] Oulu Univ Hosp, Unit Gen Practice, Oulu, Finland.
   [Jokelainen, Jari] Univ Oulu, Infrastruct Populat Studies, Oulu, Finland.
   [Valkeapaa, Nihkolas] Lapland Cent Hosp, Rovaniemi, Finland.
   [Saltevo, Juha] Cent Finland Cent Hosp, Jyvaskyla, Finland.
   [Keinanen-Kiukaanniemi, Sirkka] Hlth Ctr Selanne, Pyhajarvi, Finland.
C3 University of Oulu; University of Oulu; University of Oulu; Central
   Finland Central Hospital
RP Perkkiö, Y (corresponding author), Hlth Ctr Muonio Enontekio, Katkajarventie 75, Katkasuvanto 99320, Finland.
EM yrjo.perkkio@fimnet.fi
FU Center for Life Course Health Research, University of Oulu; Cultural
   Foundation of Finland; Health Centre of Muonio-Enontekio; Northern
   Finland Health Care Foundation
FX This work was supported by,Center for Life Course Health Research,
   University of Oulu [1];Cultural Foundation of Finland [4];Health Centre
   of Muonio-Enontekio [3]; and Northern Finland Health Care Foundation
   [2].
CR [Anonymous], MORT DIAGN YEARS 200
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NR 22
TC 0
Z9 0
U1 0
U2 0
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1239-9736
EI 2242-3982
J9 INT J CIRCUMPOL HEAL
JI Int. J. Circumpolar Health
PD JAN 1
PY 2021
VL 80
IS 1
AR 1909334
DI 10.1080/22423982.2021.1909334
PG 10
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA RN5NY
UT WOS:000640399000001
PM 33858289
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Chen, YY
   Kao, TW
   Wang, CC
   Chen, YJ
   Wu, CJ
   Lai, CH
   Chen, WL
AF Chen, Yuan-Yuei
   Kao, Tung-Wei
   Wang, Chung-Ching
   Chen, Ying-Jen
   Wu, Chen-Jung
   Lai, Ching-Huang
   Chen, Wei-Liang
TI Exposure to polycyclic aromatic hydrocarbons and risk of disability
   among an elderly population
SO ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
LA English
DT Article
DE Polycyclic aromatic hydrocarbons; Functional dependence; Disability;
   National Health and Nutrition Examination Survey
ID PERIPHERAL ARTERIAL-DISEASE; FUNCTIONAL DEPENDENCE; COGNITIVE
   IMPAIRMENT; METABOLIC SYNDROME; ASSOCIATION; CARCINOGENS; DEPRESSION;
   DEMENTIA; FORCE; SMOKE
AB Polycyclic aromatic hydrocarbons (PAHs) are environmental pollutants. Exposure to PAHs is associated with several adverse health outcomes. However, no previous study has examined the relationship between PAH exposure and functional dependence in an elderly population. Our aim was to examine whether PAH exposure was associated with functional dependence including total disability, activities of daily living (ADL), instrumental activities of daily living (IADL), leisure and social activities (LSA), lower extremity mobility (LEM), and general physical activities (GPA) in an elderly population. A total of 5816 elderly adults from the National Health and Nutrition Examination Survey (NHANES) from 2001 to 2006 were examined. PAH exposure was measured by urinary biomarkers. Functional dependence was assessed by 19 structured questions. The association between PAH exposures with functional dependence was performed by using a multivariable linear regression model. After adjusting for pertinent variables, positive associations were observed between the total number of disabilities and 2-naphthalene and 1-pyrene quartiles (all P-trend < 0.05). There was a dose-dependent relationship between 1-pyrene quartiles and all functional dependence domains, and the higher quartile of 1-pyrene was more closely associated with functional impairment (all P-trend < 0.05). PAH exposure is associated with functional dependence in American elderly adults. Future research is needed to bring to light the pathophysiological underlying mechanisms related to these findings.
C1 [Chen, Yuan-Yuei] Natl Def Med Ctr, Songshan Branch, Triserv Gen Hosp, Dept Internal Med, Taipei, Taiwan.
   [Chen, Yuan-Yuei; Kao, Tung-Wei; Wang, Chung-Ching; Chen, Ying-Jen; Wu, Chen-Jung; Chen, Wei-Liang] Natl Def Med Ctr, Sch Med, 325,Sect 2,Chang Gong Rd, Taipei 114, Taiwan.
   [Chen, Yuan-Yuei; Kao, Tung-Wei; Wang, Chung-Ching; Wu, Chen-Jung; Chen, Wei-Liang] Natl Def Med Ctr, Triserv Gen Hosp, Dept Family & Community Med, Div Family Med, Taipei, Taiwan.
   [Kao, Tung-Wei; Wu, Chen-Jung; Chen, Wei-Liang] Natl Def Med Ctr, Div Geriatr Med, Dept Family & Community Med, Triserv Gen Hosp, 325,Sect 2,Chang Gong Rd, Taipei 114, Taiwan.
   [Kao, Tung-Wei] Natl Taiwan Univ, Coll Med, Grad Inst Clin Med, Taipei, Taiwan.
   [Chen, Ying-Jen] Natl Def Med Ctr, Dept Ophthalmol, Triserv Gen Hosp, Taipei, Taiwan.
   [Wu, Chen-Jung] Taoyuan Armed Forces Gen Hosp, Dept Community Med, Div Family Med, Taoyuan, Taiwan.
   [Lai, Ching-Huang] Natl Def Med Ctr, Sch Publ Hlth, Taipei, Taiwan.
C3 Tri-Service General Hospital; National Defense Medical Center; National
   Defense Medical Center; Tri-Service General Hospital; National Defense
   Medical Center; National Defense Medical Center; Tri-Service General
   Hospital; National Taiwan University; National Defense Medical Center;
   Tri-Service General Hospital; National Defense Medical Center
RP Chen, WL (corresponding author), Natl Def Med Ctr, Sch Med, 325,Sect 2,Chang Gong Rd, Taipei 114, Taiwan.; Chen, WL (corresponding author), Natl Def Med Ctr, Triserv Gen Hosp, Dept Family & Community Med, Div Family Med, Taipei, Taiwan.; Chen, WL (corresponding author), Natl Def Med Ctr, Div Geriatr Med, Dept Family & Community Med, Triserv Gen Hosp, 325,Sect 2,Chang Gong Rd, Taipei 114, Taiwan.
EM weiliang0508@gmail.com
RI Lai, Ching-Huang/ABF-9274-2021
CR Agency for Toxic Substances and Disease Registry, 1995, TOX PROF POL AR HYDR
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NR 38
TC 10
Z9 10
U1 0
U2 13
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0944-1344
EI 1614-7499
J9 ENVIRON SCI POLLUT R
JI Environ. Sci. Pollut. Res.
PD APR
PY 2019
VL 26
IS 11
BP 10719
EP 10726
DI 10.1007/s11356-019-04498-3
PG 8
WC Environmental Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology
GA HT8ZR
UT WOS:000464854500023
PM 30778934
DA 2025-06-11
ER

PT J
AU Henry, BL
   Quintana, E
   Moore, DJ
   Garcia, J
   Montoya, JL
AF Henry, Brook L.
   Quintana, Elizabeth
   Moore, David J.
   Garcia, John
   Montoya, Jessica L.
TI Focus groups inform a mobile health intervention to promote adherence to
   a Mediterranean diet and engagement in physical activity among people
   living with HIV
SO BMC PUBLIC HEALTH
LA English
DT Article
DE Focus groups; Mediterranean diet; HIV; mHealth; Neurocognition
ID INFECTED PATIENTS; ANTIRETROVIRAL THERAPY; METABOLIC SYNDROME; ADULTS;
   BARRIERS; BIOMARKERS; INFLAMMATION; DYSLIPIDEMIA; EXPERIENCE; MEDICATION
AB BackgroundA personalized mobile health intervention (iSTEP) aims to promote a Mediterranean diet and increase physical activity, thereby improving neurocognitive functioning among persons living with HIV (PLWH). This article describes a qualitative study conducted to develop iSTEP for PLWH, including assessment of diet habits and preferences for tracking physical activity.MethodTwo focus groups, with seven and 13 PLWH respectively, discussed barriers and facilitators of a healthy diet and provided feedback to refine iSTEP components, including the feasibility of using a Fitbit and the content of text messages designed to encourage improved diet and physical activity.ResultsFocus group discussions revealed several healthy diet barriers, including housing instability, time required for food preparation, cost of healthy food, depression, gastrointestinal issues, physical disability, and changes in appetite since HIV diagnosis. Participant-identified healthy diet facilitators included affordable price options for healthy food, a structured food plan, desire to modify appearance or weight, access to medical professionals, motivation for disease prevention, and social support. Participants endorsed wearing a Fitbit on the wrist and receiving text messages as useful methods to monitor and encourage a better diet and greater physical activity.ConclusionsThese findings assisted the expansion of a mobile health intervention that promotes health behaviors in order to improve neurocognitive outcomes among PLWH.Trial registrationNCT03123731, prospectively registered on ClinicalTrials.gov, April 21, 2017.
C1 [Henry, Brook L.; Moore, David J.; Garcia, John; Montoya, Jessica L.] Univ Calif San Diego, Sch Med, Dept Psychiat, 9500 Gillman Dr, La Jolla, CA 92093 USA.
   [Quintana, Elizabeth] Univ Calif San Diego, Canc Ctr, La Jolla, CA 92093 USA.
C3 University of California System; University of California San Diego;
   University of California System; University of California San Diego
RP Henry, BL (corresponding author), Univ Calif San Diego, Sch Med, Dept Psychiat, 9500 Gillman Dr, La Jolla, CA 92093 USA.
EM blhenry@ucsd.edu
OI Moore, David/0000-0001-9699-318X
FU NINR [R01 NR016912]; NIMH [R21 MH100968, P30 MH062512]
FX This study was supported by NINR grant R01 NR016912 and NIMH grants R21
   MH100968, and P30 MH062512. The funders had no role in the study design,
   collection, analysis or interpretation of the data, writing of the
   report, or decision to submit the article for publication.
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NR 52
TC 16
Z9 16
U1 1
U2 13
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1471-2458
J9 BMC PUBLIC HEALTH
JI BMC Public Health
PD JAN 22
PY 2019
VL 19
AR 101
DI 10.1186/s12889-018-6386-5
PG 9
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA HI4FD
UT WOS:000456405600002
PM 30669986
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Lee, SY
   Lai, FY
   Shi, LS
   Chou, YC
   Yen, IC
   Chang, TC
AF Lee, Shih-Yu
   Lai, Feng-Yi
   Shi, Li-Shian
   Chou, Yu-Ching
   Yen, I-Chuan
   Chang, Tsu-Chung
TI Rhodiola crenulata extract suppresses hepatic
   gluconeogenesis via activation of the AMPK pathway
SO PHYTOMEDICINE
LA English
DT Article
DE Rhodiola crenulata; Hepatic gluconeogenesis; AMPK
ID ISOLATED NEUROGLIAL CELLS; PROTEIN-KINASE; METABOLIC SYNDROME; SIGNALING
   PATHWAY; GLUCOSE-UPTAKE; IDENTIFICATION; SALIDROSIDE; INHIBITION;
   EXPRESSION; LIVER
AB Background: Rhodiola, a popular herb, has been used for treating high altitude sicknesses, depression, fatigue, and diabetes. However, the detailed mechanisms by which Rhodiola crenulata functions in the liver need further clarification.
   Purpose: The current study was designed to examine the effects of Rhodiola crenulata root extract (RCE) on hepatic glucose production.
   Methods: Human hepatoma HepG2 cells were treated with RCE for 6 h. Glucose production, the expression level of p-AMPK, and the expression of key gluconeogenic genes were measured. The effects of RCE were also studied in Sprague-Dawley (SD) rats. The efficacy and underlying mechanism of RCE in the liver were examined.
   Results: RCE significantly suppressed glucose production and gluconeogenic gene expression in HepG2 cells while activating the AMPK signaling pathway. Interestingly, RCE-suppressed hepatic gluconeogenesis was eliminated by an AMPK-specific inhibitor, but not by the PI3K/AKT-specific inhibitor. In addition, oral administration of RCE significantly increased phosphoiylated AMPK levels and inhibited gluconeogenic gene expression in the rat liver. Furthermore, RCE treatment also decreased plasma glucose concentration in rats.
   Conclusion: We present in vitro and in vivo evidence that RCE might exert the glucose-lowering effect partly by inhibiting hepatic gluconeogenesis through activating the AMPK signaling pathway. These findings provide evidence that Rhodiola crenulata may be helpful for the management of type II diabetes. (C) 2015 Elsevier GmbH. All rights reserved.
C1 [Lee, Shih-Yu] Natl Def Med Ctr, Inst Aerosp Undersea Med, Taipei 114, Taiwan.
   [Lai, Feng-Yi; Chang, Tsu-Chung] Natl Def Med Ctr, Dept Biochem, Taipei 114, Taiwan.
   [Shi, Li-Shian] Natl Def Med Ctr, Dept Biotechnol, Taipei 114, Taiwan.
   [Chou, Yu-Ching] Natl Def Med Ctr, Sch Publ Hlth, Taipei 114, Taiwan.
   [Yen, I-Chuan] Natl Def Med Ctr, Sch Pharm, Taipei 114, Taiwan.
   [Chang, Tsu-Chung] China Med Univ, Grad Inst Basic Med Sci, Taichung, Taiwan.
C3 National Defense Medical Center; National Defense Medical Center;
   National Defense Medical Center; National Defense Medical Center;
   National Defense Medical Center; China Medical University Taiwan
RP Chang, TC (corresponding author), Natl Def Med Ctr, Dept Biochem, POB 90048-501, Taipei 114, Taiwan.
EM leeshihyuno1@mail.ndmctsgh.edu.tw; rocodo29@hotmail.com;
   lsshi@sunws.nfu.edu.tw; trishow@mail.ndmctsgh.edu.tw;
   yenichuan@mail.ndmctsgh.edu.tw; tcchang@mail.ndmctsgh.edu.tw
RI YU-CHING, CHOU/AAV-1623-2020; Lee, Shih-Yu/AAO-4110-2020; Liao,
   Chun-Hsing/HTQ-5271-2023
OI Lee, Shih-Yu/0000-0002-4713-6410
FU Ministry of Science and Technology [NSC 101-2320-B-016-010-MY2, MOST
   103-2320-B-016-005]; Ministry of National Defense, Taipei, Taiwan, ROC
   [MAB-102-9, 103-M019, MAB-103-M078]
FX The study was supported by grants from the Ministry of Science and
   Technology (NSC 101-2320-B-016-010-MY2 and MOST 103-2320-B-016-005 to
   T.-C. Chang) and the Ministry of National Defense (MAB-102-9 and
   103-M019 to T.-C. Chang; MAB-103-M078 to S.-Y. Lee), Taipei, Taiwan,
   ROC.
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NR 29
TC 35
Z9 42
U1 1
U2 53
PU ELSEVIER GMBH, URBAN & FISCHER VERLAG
PI JENA
PA OFFICE JENA, P O BOX 100537, 07705 JENA, GERMANY
SN 0944-7113
EI 1618-095X
J9 PHYTOMEDICINE
JI Phytomedicine
PD APR 15
PY 2015
VL 22
IS 4
BP 477
EP 486
DI 10.1016/j.phymed.2015.01.016
PG 10
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA CG8KL
UT WOS:000353556300008
PM 25925970
DA 2025-06-11
ER

PT J
AU Champaneri, S
   Xu, XQ
   Carnethon, MR
   Bertoni, AG
   Seeman, T
   Roux, AD
   Golden, SH
AF Champaneri, Shivam
   Xu, Xiaoqiang
   Carnethon, Mercedes R.
   Bertoni, Alain G.
   Seeman, Teresa
   Roux, Ana Diez
   Golden, Sherita Hill
TI Diurnal salivary cortisol and urinary catecholamines are associated with
   diabetes mellitus: the Multi-Ethnic Study of Atherosclerosis
SO METABOLISM-CLINICAL AND EXPERIMENTAL
LA English
DT Article
ID METABOLIC SYNDROME; NORADRENALINE CONCENTRATIONS; AUTONOMIC DYSFUNCTION;
   BLOOD-PRESSURE; TYPE-2; OBESITY; NOREPINEPHRINE; ADRENALINE; DEPRESSION;
   NEUROPATHY
AB The objective was to examine the cross-sectional association of diurnal salivary cortisol curve components and urinary catecholamines with diabetes status. Up to 18 salivary cortisol samples over 3 days and overnight urinary catecholamines were collected from 1002 participants in the Multi-Ethnic Study of Atherosclerosis. Diabetes was defined as a fasting blood glucose of at least 126 mg/dL or medication use. Cortisol curve measures included awakening cortisol, cortisol awakening response, early decline, late decline, and cortisol area under the curve (AUC). Urinary catecholamines included epinephrine, norepinephrine, and dopamine. Participants with diabetes had significantly lower cortisol awakening response (beta = -0.19; 95% confidence interval [CI], -0.34 to -0.04) than those without diabetes in multivariable models. Whereas men with diabetes had a nonsignificant trend toward lower total AUC (beta = -1.56; 95% CI, -3.93 to 0.80), women with diabetes had significantly higher total AUC (beta = 2.62; 95% CI, 0.72 to 4.51) (P = .02 for interaction) compared with those without diabetes. Men but not women with diabetes had significantly lower urinary catecholamines compared with those without diabetes (P < .05). Diabetes is associated with neuroendocrine dysregulation, which may differ by sex. Further studies are needed to determine the role of the neuroendocrine system in the pathophysiology of diabetes. (c) 2012 Elsevier Inc. All rights reserved.
C1 [Golden, Sherita Hill] Johns Hopkins Univ, Sch Med, Div Endocrinol & Metab, Baltimore, MD 21205 USA.
   [Champaneri, Shivam; Xu, Xiaoqiang; Golden, Sherita Hill] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Med, Baltimore, MD USA.
   [Golden, Sherita Hill] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA.
   [Carnethon, Mercedes R.] Northwestern Univ, Feinberg Sch Med, Dept Prevent Med, Chicago, IL 60611 USA.
   [Bertoni, Alain G.] Wake Forest Univ Hlth Sci, Div Publ Hlth Sci, Winston Salem, NC USA.
   [Seeman, Teresa] Univ Calif Los Angeles, David Geffen Sch Med, Div Geriatr, Los Angeles, CA 90095 USA.
   [Roux, Ana Diez] Univ Michigan, Dept Epidemiol, Ann Arbor, MI 48109 USA.
C3 Johns Hopkins University; Johns Hopkins University; Johns Hopkins
   Bloomberg School of Public Health; Johns Hopkins University; Johns
   Hopkins Bloomberg School of Public Health; Northwestern University;
   Feinberg School of Medicine; Wake Forest University; Wake Forest
   University School of Medicine; University of California System;
   University of California Los Angeles; University of California Los
   Angeles Medical Center; David Geffen School of Medicine at UCLA;
   University of Michigan System; University of Michigan
RP Golden, SH (corresponding author), Johns Hopkins Univ, Sch Med, Div Endocrinol & Metab, Baltimore, MD 21205 USA.
EM sahill@jhmi.edu
RI XU, Xiaoqiang/AAA-5897-2022
OI Bertoni, Alain/0000-0002-7503-6273; Carnethon,
   Mercedes/0000-0001-7035-0848
FU National Heart, Lung, and Blood Institute [NO1-HC-95159, NO1-HC-95160,
   NO1-HC-95161, NO1-HC-95162, NO1-HC-95163, NO1-HC-95164, NO1-HC-95165,
   NO1-HC-95169]; National Institute of Diabetes, Digestive, and Kidney
   Diseases, Bethesda, MD [5 K23 DK071565]; Ruth L. Kirschstein National
   Research Service [T32]; National Institutes of Health; National Heart,
   Lung, and Blood Institute;  [RO1 HL076831]
FX MESA was supported by contracts NO1-HC-95159 through NO1-HC-95165 and
   NO1-HC-95169 from the National Heart, Lung, and Blood Institute. MESA
   Stress Study was supported by RO1 HL076831 (PI: Dr Diez-Roux). Dr Golden
   was supported by a Patient-Oriented Mentored Scientist Award through the
   National Institute of Diabetes, Digestive, and Kidney Diseases,
   Bethesda, MD (5 K23 DK071565). Dr Champaneri was supported by a training
   grant (T32 Ruth L. Kirschstein National Research Service Award).SC, XX,
   MC, AB, and TS have nothing to declare. ADR is funded by a research
   grant from the National Institutes of Health. SHG is funded by National
   Institutes of Health and National Heart, Lung, and Blood Institute
   contracts that support MESA and MESA Stress.
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NR 49
TC 65
Z9 73
U1 0
U2 14
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0026-0495
EI 1532-8600
J9 METABOLISM
JI Metab.-Clin. Exp.
PD JUL
PY 2012
VL 61
IS 7
BP 986
EP 995
DI 10.1016/j.metabol.2011.11.006
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 960EV
UT WOS:000305371700011
PM 22209664
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Accattato, F
   Greco, M
   Pullano, SA
   Carè, I
   Fiorillo, AS
   Pujia, A
   Montalcini, T
   Foti, DP
   Brunetti, A
   Gulletta, E
AF Accattato, Francesca
   Greco, Marta
   Pullano, Salvatore A.
   Care, Ilaria
   Fiorillo, Antonino S.
   Pujia, Arturo
   Montalcini, Tiziana
   Foti, Daniela P.
   Brunetti, Antonio
   Gulletta, Elio
TI Effects of acute physical exercise on oxidative stress and inflammatory
   status in young, sedentary obese subjects
SO PLOS ONE
LA English
DT Article
ID EPIDERMAL-GROWTH-FACTOR; ADIPOSE-TISSUE; INSULIN-RESISTANCE;
   SKELETAL-MUSCLE; METABOLIC SYNDROME; GENE-EXPRESSION; HEART-FAILURE;
   OLDER-ADULTS; HYPOXIA; MEN
AB Circulating oxidative stress and pro-inflammatory markers change after regular physical exercise; however, how a short session of acute physical activity affects the inflammatory status and redox balance in sedentary individuals is still unclear. Aim of this study is to assess antioxidant and inflammatory parameters, both at rest and after acute exercise, in sedentary young men with or without obesity. Thirty sedentary male volunteers, aged 20-45 (mean age 32 +/- 7 years), were recruited, divided into 3 groups (normal weight: BMI < 25 kg/m(2); overweight to moderate obesity: 25-35 kg/m(2); severe obesity: 35-40 kg/m(2)), and their blood samples collected before and after a 20-min run at similar to 70% of their VO2max for the measurement of Glutathione Reductase, Glutathione Peroxidase, Superoxide Dismutase, Total Antioxidant Status (TAS) and cytokines (IL-2, IL-4, IL-6, IL-8, IL-10, IL-1 alpha, IL-1 beta, TNF alpha, MCP-1, VEGF, IFNY, EGF). Inter-group comparisons demonstrated significantly higher Glutathione Reductase activity in severely obese subjects in the post-exercise period (P = 0.036), and higher EGF levels in normal weight individuals, either before (P = 0.003) and after exercise (P = 0.05). Intra-group comparisons showed that the acute exercise stress induced a significant increase in Glutathione Reductase activity in severely obese subjects only (P = 0.007), a significant decrease in MCP-1 in the normal weight group (P = 0.02), and a decrease in EGF levels in all groups (normal weight: P = 0.025, overweight/moderate obesity: P = 0.04, severe obesity: P = 0.018). Altogether, these findings suggest that in sedentary individuals with different ranges of BMI, Glutathione Reductase and distinct cytokines are differentially involved into the adaptive metabolic changes and redox responses induced by physical exercise. Therefore, these biomarkers may have the potential to identify individuals at higher risk for developing diseases pathophysiologically linked to oxidative stress.
C1 [Accattato, Francesca; Greco, Marta; Pullano, Salvatore A.; Fiorillo, Antonino S.; Foti, Daniela P.; Brunetti, Antonio; Gulletta, Elio] Magna Graecia Univ Catanzaro, Dept Hlth Sci, Catanzaro, Italy.
   [Care, Ilaria; Pujia, Arturo; Montalcini, Tiziana] Magna Graecia Univ Catanzaro, Dept Med & Surg Sci, Catanzaro, Italy.
C3 Magna Graecia University of Catanzaro; Magna Graecia University of
   Catanzaro
RP Foti, DP (corresponding author), Magna Graecia Univ Catanzaro, Dept Hlth Sci, Catanzaro, Italy.
EM foti@unicz.it
RI Montalcini, Tiziana/AGV-1479-2022; Greco, Marta/K-8227-2016; Foti,
   Daniela/K-8038-2016; Brunetti, Antonio/K-7756-2016; Brunetti,
   Arturo/AAE-5261-2019; Pullano, Salvatore Andrea/H-1149-2016
OI Pullano, Salvatore Andrea/0000-0003-3391-1698; Brunetti,
   Antonio/0000-0003-1533-8779
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NR 71
TC 79
Z9 82
U1 0
U2 11
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JUN 5
PY 2017
VL 12
IS 6
AR e0178900
DI 10.1371/journal.pone.0178900
PG 13
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA EW9KF
UT WOS:000402837600053
PM 28582461
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Machado, MV
   Ravasco, P
   Jesus, L
   Marques-Vidal, P
   Oliveira, CR
   Proenca, T
   Baldeiras, I
   Camilo, ME
   Cortez-Pinto, H
AF Machado, Maiana Verdelho
   Ravasco, Paula
   Jesus, Lia
   Marques-Vidal, Pedro
   Oliveira, Catarina R.
   Proenca, Teresa
   Baldeiras, Ines
   Camilo, Maria Ermelinda
   Cortez-Pinto, Helena
TI Blood oxidative stress markers in non-alcoholic steatohepatitis and how
   it correlates with diet
SO SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
LA English
DT Article
DE dietary intake; non-alcoholic steatohepatitis; oxidative stress
ID FATTY LIVER-DISEASE; LIPID-PEROXIDATION; ALPHA-TOCOPHEROL;
   INSULIN-RESISTANCE; ANTIOXIDANT STATUS; LIQUID-CHROMATOGRAPHY;
   GLUTATHIONE CONTENT; METABOLIC SYNDROME; HEPATIC STEATOSIS;
   BETA-CAROTENE
AB Objective. Non-alcoholic fatty liver disease is a common condition that can progress to endstage liver disease. The steatotic liver seems to be particularly susceptible to oxidative stress damage. The aim of this study was to evaluate the redox state in patients with non-alcoholic steatohepatitis (NASH) and its correlation with dietary intake. Material and methods. Plasma concentrations of 4-hydroxynonenal (4-HNE), 8-hydroxydeoxyguanosine (8-OHdG), reduced and oxidized glutathione (GSH and GSSG), vitamins A and E, total antioxidant status (TAS), glutathione peroxidase (GSH-Px) and reductase (GSH-Red) erythrocyte activities were compared between 43 NASH patients and 33 healthy controls. 4-HNE, GSH-Px, GSH-Red and TAS were evaluated by spectrophotometry, 8-OHdG by ELISA assay, GSH and GSSG by fluorimetric assay and vitamins A and E by high performance liquid chromatography. Dietary habits were also evaluated in these patients. Results. GSH levels (21.1 +/- 18.3 versus 33.1 +/- 22.2 mu M, p = 0.01) and GSH/GSSG ratio (0.9 +/- 0.7 versus 1.5 +/- 0.8, p = 0.01) were lower and TAS (832 +/- 146 versus 630 +/- 140 mu M, p < 0.001) and vitamin E (47.1 +/- 14.9 versus 34.5 +/- 7.3 mu M, p < 0.001) were higher in NASH patients, although there was no difference in GSH-Px and GSH-Red activities, 8-OHdG and 4-HNE levels between groups. After adjusting for total energy consumption, a negative correlation was found with total and saturated fat intake and GSH/GSSG ratio, and a positive correlation with carbohydrates, fiber, monounsaturated fatty acids (MUFA), polyunsaturated fatty acids (PUFA), specifically N-3 PUFA, and vitamins E, C, selenium and folate. Conclusions. Our data suggest an impaired glutathione metabolism towards an oxidant status in NASH patients, correlating with a higher intake of saturated fat and a lower intake of carbohydrates. Plasmatic concentrations of oxidative stress cellular markers did not translate to hepatic oxidative damage.
C1 [Machado, Maiana Verdelho; Ravasco, Paula; Jesus, Lia; Marques-Vidal, Pedro; Camilo, Maria Ermelinda; Cortez-Pinto, Helena] Fac Med Lisbon, Inst Med Mol, Unidade Nutr & Metab, Lisbon, Portugal.
   [Machado, Maiana Verdelho; Cortez-Pinto, Helena] Fac Med Lisbon, Dept Gastroenterol, Lisbon, Portugal.
   [Oliveira, Catarina R.; Proenca, Teresa; Baldeiras, Ines] Univ Coimbra, Fac Med, Ctr Neuroquim, P-3000 Coimbra, Portugal.
C3 Universidade de Lisboa; Universidade de Lisboa; Universidade de Coimbra
RP Cortez-Pinto, H (corresponding author), Hosp Santa Maria, Unidade Gastroenterol, Av Prof Egas Moniz, PT-1649035 Lisbon, Portugal.
EM hlcortezpinto@netcabo.pt
RI Machado, Magno/C-2671-2013; Oliveira, Catarina/F-3685-2010;
   Cortez-Pinto, Helena/AAN-2712-2020; Marques-Vidal, Pedro/C-9449-2009
OI Cortez-Pinto, Helena/0000-0002-8537-8744; Baldeiras,
   Ines/0000-0002-8106-7308; Ravasco, Paula/0000-0002-6056-8269; Oliveira,
   Catarina/0000-0001-6942-4328; Marques-Vidal, Pedro/0000-0002-4548-8500
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NR 52
TC 68
Z9 74
U1 0
U2 14
PU TAYLOR & FRANCIS AS
PI OSLO
PA PO BOX 12 POSTHUSET, NO-0051 OSLO, NORWAY
SN 0036-5521
J9 SCAND J GASTROENTERO
JI Scand. J. Gastroenterol.
PY 2008
VL 43
IS 1
BP 95
EP 102
DI 10.1080/00365520701559003
PG 8
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 244CF
UT WOS:000251842900013
PM 18938777
DA 2025-06-11
ER

PT J
AU Yang, T
   Gao, X
   Sandberg, M
   Zollbrecht, C
   Zhang, XM
   Hezel, M
   Liu, M
   Peleli, M
   Lai, EY
   Harris, RA
   Persson, AEG
   Fredholm, BB
   Jansson, L
   Carlström, M
AF Yang, Ting
   Gao, Xiang
   Sandberg, Monica
   Zollbrecht, Christa
   Zhang, Xing-Mei
   Hezel, Michael
   Liu, Ming
   Peleli, Maria
   Lai, En-Yin
   Harris, Robert A.
   Persson, A. Erik G.
   Fredholm, Bertil B.
   Jansson, Leif
   Carlstrom, Mattias
TI Abrogation of adenosine A1 receptor signalling improves
   metabolic regulation in mice by modulating oxidative stress and
   inflammatory responses
SO DIABETOLOGIA
LA English
DT Article
DE Insulin sensitivity and resistance; Islets; Metabolic physiology in
   vivo; Metabolic syndrome; Oxidative stress; Type 2 diabetes; Visceral
   adipose tissue
ID TUMOR-NECROSIS-FACTOR; ADIPOSE-TISSUE; INSULIN-RESISTANCE; LINKING
   OBESITY; LEPTIN; EXPRESSION; SECRETION; LIPOLYSIS; GLUCAGON; WEIGHT
AB Aims/hypothesis Adenosine is an important regulator of metabolism; however, the role of the A(1) receptor during ageing and obesity is unclear. The aim of this study was to investigate the effects of A(1) signalling in modulating metabolic function during ageing.
   Methods Age-matched young and aged A (1) (also known as Adora1)-knockout (A (1) (-/-)) and wild-type (A (1) (+/+)) mice were used. Metabolic regulation was evaluated by body composition, and glucose and insulin tolerance tests. Isolated islets and islet arterioles were used to detect islet endocrine and vascular function. Oxidative stress and inflammation status were measured in metabolic organs and systemically.
   Results Advanced age was associated with both reduced glucose clearance and insulin sensitivity, as well as increased visceral adipose tissue (VAT) in A (1) (+/+) compared with A (1) (-/-) mice. Islet morphology and insulin content were similar between genotypes, but relative changes in in vitro insulin release following glucose stimulation were reduced in aged A (1) (+/+) compared with A (1) (-/-) mice. Islet arteriolar responses to angiotensin II were stronger in aged A (1) (+/+) mice, this being associated with increased NADPH oxidase activity. Ageing resulted in multiple changes in A (1) (+/+) compared with A (1) (-/-) mice, including enhanced NADPH oxidase-derived O-2 (-) formation and NADPH oxidase isoform 2 (Nox2) protein expression in pancreas and VAT; elevated levels of circulating insulin, leptin and proinflammatory cytokines (TNF-alpha, IL-1 beta, IL-6 and IL-12); and accumulation of CD4(+) T cells in VAT. This was associated with impaired insulin signalling in VAT from aged A (1) (+/+) mice.
   Conclusions/interpretation These studies emphasise that A(1) receptors regulate metabolism and islet endocrine and vascular functions during ageing, including via the modulation of oxidative stress and inflammatory responses, among other things.
C1 [Yang, Ting; Zollbrecht, Christa; Hezel, Michael; Liu, Ming; Peleli, Maria; Fredholm, Bertil B.; Carlstrom, Mattias] Karolinska Inst, Dept Physiol & Pharmacol, SE-17177 Stockholm, Sweden.
   [Gao, Xiang; Sandberg, Monica; Persson, A. Erik G.; Jansson, Leif] Uppsala Univ, Dept Med Cell Biol, Uppsala, Sweden.
   [Zhang, Xing-Mei; Harris, Robert A.] Karolinska Inst, Dept Clin Neurosci, SE-17177 Stockholm, Sweden.
   [Lai, En-Yin; Carlstrom, Mattias] Georgetown Univ, Kidney & Vasc Res Ctr, Div Nephrol & Hypertens & Hypertens, Washington, DC USA.
C3 Karolinska Institutet; Uppsala University; Karolinska Institutet;
   Georgetown University
RP Carlström, M (corresponding author), Karolinska Inst, Dept Physiol & Pharmacol, Nanna Svartz Vag 2, SE-17177 Stockholm, Sweden.
EM mattias.carlstrom@ki.se
RI Peleli, Maria/AAQ-2326-2021; Harris, Robert/I-6234-2019; Carlstrom,
   Mattias/E-7350-2015
OI Carlstrom, Mattias/0000-0001-9923-8729; Harris,
   Robert/0000-0003-4990-509X
FU Swedish Research Council [521-2011-2639, 521-2011-3777]; Swedish Heart
   and Lung Foundation [20140448, 20110589]; Jeanssons Foundation
   [JS2013-00064]; Wenner-Gren Foundation; Family Ernfors Fund; Swedish
   Society of Medicine; Novo Nordisk Foundation Excellence Project; Swedish
   Diabetes Foundation; EXODIAb grant; Swedish Society of Medical Research
   (SSMF)
FX This work was supported by grants from the Swedish Research Council
   (521-2011-2639 to MC and 521-2011-3777 to LJ), Swedish Heart and Lung
   Foundation (20140448, 20110589), Jeanssons Foundation (JS2013-00064),
   Swedish Diabetes Foundation, an EXODIAb grant, Swedish Society of
   Medical Research (SSMF), the Wenner-Gren Foundation, the Family Ernfors
   Fund, the Swedish Society of Medicine and Novo Nordisk Foundation
   Excellence Project.
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NR 51
TC 35
Z9 38
U1 0
U2 8
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0012-186X
EI 1432-0428
J9 DIABETOLOGIA
JI Diabetologia
PD JUL
PY 2015
VL 58
IS 7
BP 1610
EP 1620
DI 10.1007/s00125-015-3570-3
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA CK8ZL
UT WOS:000356528900026
PM 25835725
OA Bronze
DA 2025-06-11
ER

PT J
AU Dinh, CHL
   Szabo, A
   Camer, D
   Yu, YH
   Wang, HQ
   Huang, XF
AF Dinh, Chi H. L.
   Szabo, Alexander
   Camer, Danielle
   Yu, Yinghua
   Wang, Hongqin
   Huang, Xu-Feng
TI Bardoxolone methyl prevents fat deposition and inflammation in the
   visceral fat of mice fed a high-fat diet
SO CHEMICO-BIOLOGICAL INTERACTIONS
LA English
DT Article
DE Obesity; Adipose tissue; Inflammation; Bardoxolone methyl
ID WHITE ADIPOSE-TISSUE; ACTIVATED SIGNALING PATHWAYS;
   SYMPATHETIC-NERVOUS-SYSTEM; INCREASED OXIDATIVE STRESS;
   TYROSINE-HYDROXYLASE; INSULIN-RESISTANCE; METABOLIC SYNDROME; LEPTIN
   RESISTANCE; INDUCED OBESITY; EXPRESSION
AB Key features of diet-induced obesity are visceral fat deposition, macrophage infiltration and inflammation that can lead to metabolic disorders. This study examined the effects of bardoxolone methyl (BARD) in preventing obesity and inflammation in the visceral fat of mice fed high-fat diet. Male C57BL/6J mice were fed a high-fat diet (HFD), a low-fat diet (LFD, i.e., lab chow diet) or a high-fat diet supplemented with BARD (HFD/BARD) for 21 weeks. BARD at a dosage of 10 mg/kg body weight was administered orally in drinking water. Histology, immunohistochemistry and Western blot were used for the analysis of epididymal adipose tissue. Morphological results demonstrated that HFD fed mice treated with BARD had smaller adipocytes and fewer macrophages present in epididymal adipose tissue than the HFD group. Furthermore, BARD administration reduced the inflammatory profile in this tissue by increasing the expression of nuclear factor of kappa-light-polypeptide gene enhancer in B-cells inhibitor, alpha (I kappa B-alpha) protein and decreasing the protein expression of tumour necrosis factor alpha (TNF-alpha). BARD also prevented oxidative stress reflected by a reduction in stress activated proteins, including signal transducer and activator of transcription 3 (STAT3), protein kinase B (Akt), extracellular-signal-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK). BARD administration activated the sympathetic nervous system in epididymal adipose tissue assessed by the increased synthesis of tyrosine hydroxylase (TH) and uncoupling protein 2 (UCP2). The expression of inflammatory and sympathetic nervous system proteins in BARD mice fed a HFD was equivalent to that of the LFD control mice, indicating the anti-inflammatory and anti-obesity properties of this drug. In conclusion, the oral administration of BARD in HFD mice prevented fat deposition, inflammation and oxidative stress, and improved sympathetic activity in visceral fat. This study suggests a potential therapeutic role of BARD in preventing the development of obesity. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
C1 [Dinh, Chi H. L.; Szabo, Alexander; Camer, Danielle; Yu, Yinghua; Wang, Hongqin; Huang, Xu-Feng] Univ Wollongong, Sch Med, Ctr Translat Neurosci, Wollongong, NSW 2522, Australia.
   [Dinh, Chi H. L.; Szabo, Alexander; Camer, Danielle; Yu, Yinghua; Wang, Hongqin; Huang, Xu-Feng] Illawarra Hlth & Med Res Inst, Wollongong, NSW 2522, Australia.
   [Szabo, Alexander] Australian Nucl Sci & Technol Org, ANSTO LifeSci, Menai, NSW 2234, Australia.
C3 University of Wollongong; Illawarra Health & Medical Research Institute;
   University of Wollongong; Australian Nuclear Science & Technology
   Organisation
RP Huang, XF (corresponding author), Univ Wollongong, Illawarra Hlth & Med Res Inst, Northfields Ave, Wollongong, NSW 2522, Australia.
EM xhuang@uow.edu.au
RI Huang, Xu-Feng/D-6053-2013; Huang, Xu-Feng/H-7408-2015
OI Huang, Xu-Feng/0000-0002-5895-2253; Camer, Danielle/0000-0003-2259-2767;
   Yu, Yinghua/0000-0003-2508-7512
FU Diabetes Australia Trust
FX This research was funded by the Diabetes Australia Trust to Prof.
   Xu-Feng Huang, 2011. C.H.L. Dinh completed the experiments, data
   analysis and wrote the manuscript. A. Szabo, Y. Yu and X. Huang
   contributed to the experimental design, data collection and integration
   and reviewing the manuscript. D. Camer contributed to animal work and
   manuscript revision. H. Wang contributed to data collection.
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NR 72
TC 21
Z9 22
U1 0
U2 18
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0009-2797
EI 1872-7786
J9 CHEM-BIOL INTERACT
JI Chem.-Biol. Interact.
PD MAR 5
PY 2015
VL 229
BP 1
EP 8
DI 10.1016/j.cbi.2015.01.025
PG 8
WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology
GA CE7VU
UT WOS:000352050800001
PM 25637688
DA 2025-06-11
ER

PT J
AU Citko, A
   Górski, S
   Marcinowicz, L
   Mateusz, C
   Matylda, S
AF Citko, Anna
   Gorski, Stanislaw
   Marcinowicz, Ludmila
   Mateusz, Cybulski
   Matylda, Sierakowska
TI Nonspecific cervical spine pain/neck pain/in medical personnel of
   north-eastern Poland-A cross-sectional study
SO FRONTIERS IN MEDICINE
LA English
DT Article
DE nurses; paramedics; neck pain (NP); spondylogenic pain syndrome;
   predictive factors
ID LOW-BACK-PAIN; RISK-FACTORS; NECK PAIN; QUESTIONNAIRE; RADICULOPATHY;
   CONSEQUENCES; PREVALENCE
AB Both mechanical and psychological overload are inherent to the work of nurses and paramedics, resulting spondylogenic pain. Aim of the study: To identify potential risk factors influencing the prevalence of non-specific cervical spine pain in professionally active nurses and paramedics. Material and methods: 324 nurses (53.2% of the total) and 285 paramedics (46.8%) were included in the study-609 people in total. The study was carried out using an auditorium survey technique supervised by the researchers. The methods used were: Nordic Musculoskeletal Questionnaire, a spinal pain questionnaire validated according to IEA guidelines, a short version of the IPAQ and the author's survey questionnaire, concerning sociodemographic data, chronic diseases including metabolic syndrome (MetS). A univariate logistic regression model was used in the statistical analysis. The level of statistical significance was taken as p < 0.05. Results: Recurrent NP was significantly more common in paramedics compared to nurses (29.5 % vs. 9.3 %; p < 0.0001). In a univariate logistic regression model, the risk of NP was significantly increased by: length of service > 15 years (p < 0.024), presence of: low back pain (p < 0.0001), type 2 diabetes (p = 0.013), hypertension (p < 0.001), depression (p < 0.01). Of the modifiable factors, the risk of NP was significantly increased by high physical activity and short sleep <7 h (p < 0.001).
C1 [Citko, Anna] Akad Med Nauk Stosowanych i Holistycznych, Warsaw, Mazowieckie Voi, Poland.
   [Citko, Anna] European Univ Appl Med & Social Sci, Olsztyn, Poland.
   [Gorski, Stanislaw] Jagiellonian Univ, Med Coll, Dept Med Educ, Krakow, Malopolskie Voi, Poland.
   [Marcinowicz, Ludmila] Med Univ Bialystok, Fac Hlth Sci, Dept Obstet Gynecol & Matern Care, Bialystok, Podlaskie Voivo, Poland.
   [Mateusz, Cybulski; Matylda, Sierakowska] Med Univ Bialystok, Fac Hlth Sci, Dept Integrated Med Care, Bialystok, Podlaskie Voivo, Poland.
C3 Jagiellonian University; Collegium Medicum Jagiellonian University;
   Medical University of Bialystok; Medical University of Bialystok
RP Citko, A (corresponding author), Akad Med Nauk Stosowanych i Holistycznych, Warsaw, Mazowieckie Voi, Poland.; Citko, A (corresponding author), European Univ Appl Med & Social Sci, Olsztyn, Poland.; Mateusz, C (corresponding author), Med Univ Bialystok, Fac Hlth Sci, Dept Integrated Med Care, Bialystok, Podlaskie Voivo, Poland.
EM anka234@gmail.com; mateusz.cybulski@umb.edu.pl
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NR 42
TC 0
Z9 0
U1 2
U2 2
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 2296-858X
J9 FRONT MED-LAUSANNE
JI Front. Med.
PD DEC 9
PY 2024
VL 11
AR 1466370
DI 10.3389/fmed.2024.1466370
PG 10
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA Q0P0F
UT WOS:001381800900001
PM 39717177
OA gold
DA 2025-06-11
ER

PT J
AU Persynaki, A
   Karras, S
   Pichard, C
AF Persynaki, Angeliki
   Karras, Spyridon
   Pichard, Claude
TI Unraveling the metabolic health benefits of fasting related to religious
   beliefs: A narrative review
SO NUTRITION
LA English
DT Review
DE Religious fasting; Health benefits; Side-effects; Intermittent fasting;
   Alternate day fasting
ID CALORIC RESTRICTION; BODY-COMPOSITION; RISK-FACTORS; DANIEL FAST;
   RAMADAN; DIET; PROFILE; SUPPLEMENTATION; NUTRIENT; GLUCOSE
AB Periodic fasting, under a religious aspect, has been adopted by humans for centuries as a crucial pathway of spiritual purification. Caloric restriction, with or without exclusion of certain types of food, is often a key component. Fasting varies significantly among different populations according to cultural habits and local climate conditions. Religious fasting in terms of patterns (continuous versus intermittent) and duration can vary from 1 to 200 d; thus, the positive and negative impact on health can be considerable. Advantages of religious fasting are claimed by many but have been explored mainly by a limited number of studies conducted in Buddhist, Christian, or Muslim populations. These trials indicate that religious fasting has beneficial effects on body weight and glycemia, cardiometabolic risk markers, and oxidative stress parameters. Animals exposed to a diet mimicking fasting have demonstrated weight loss as well as lowered plasma levels of glucose, triacylglycerols, and insulin growth factor-1, although lean body mass remained stable. Diabetic mice on repeated intermittent fasting had less insulin resistance that mice fed ad libitum. The long-term significance of such changes on global health remains to be explored. This review summarizes the data available with regard to benefits of fasting followed for religious reasons on human health, body anthropometry, and cardio-metabolic risk markers; aims to bridge the current knowledge gap on available evidence and suggests considerations for the future research agenda. Future studies should explore every type of religious fasting, as well as their consequences in subpopulations such as children, pregnant women, and the elderly, or patients with chronic metabolic diseases.(C) 2016 Elsevier Inc. All rights reserved.
C1 [Persynaki, Angeliki; Pichard, Claude] Univ Hosp Geneva, Clin Nutr, Geneva, Switzerland.
   [Karras, Spyridon] AHEPA Hosp, Dept Internal Med 1, Div Endocrinol & Metab, Thessaloniki, Greece.
C3 University of Geneva; Aristotle University of Thessaloniki; Ahepa
   University Hospital
RP Persynaki, A (corresponding author), Univ Hosp Geneva, Clin Nutr, Geneva, Switzerland.
EM Angeliki.Persynaki@hcuge.ch
OI Persynaki, Angeliki/0000-0003-3219-8042; Karras,
   Spyridon/0000-0002-4225-2746
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NR 39
TC 84
Z9 90
U1 0
U2 72
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0899-9007
EI 1873-1244
J9 NUTRITION
JI Nutrition
PD MAR
PY 2017
VL 35
BP 14
EP 20
DI 10.1016/j.nut.2016.10.005
PG 7
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA EP9MO
UT WOS:000397697900003
PM 28241983
DA 2025-06-11
ER

PT J
AU van Dijk, GM
   Kavousi, M
   Troup, J
   Franco, OH
AF van Dijk, Gabriella M.
   Kavousi, Maryam
   Troup, Jenna
   Franco, Oscar H.
TI Health issues for menopausal women: The top 11 conditions have common
   solutions
SO MATURITAS
LA English
DT Review
DE Noncommunicable diseases; Menopause; Risk Factors; Interventions;
   Nutrition; Lifestyle
ID POSTMENOPAUSAL HORMONE-THERAPY; CARDIOVASCULAR-DISEASE; REPLACEMENT
   THERAPY; SYSTEMATIC ANALYSIS; BREAST-CANCER; GLOBAL BURDEN; 187
   COUNTRIES; HOT FLASHES; VITAMIN-D; RISK
AB Multiple health issues affect women throughout the life course differently from men, or do not affect men at all. Although attention to women's health is important in all stages in life, health among middle-aged and elderly women has not received sufficient attention by scientists and policy-makers. Related to the menopausal transition and the experiences accumulated until that age, many diseases occur or further develop in middle-aged and elderly women. To improve women's quality of life and guarantee a long-lasting and active role for middle-aged and elderly women in society, prevention of chronic diseases and disability is a key aspect.
   In this manuscript we give an overview of the major health issues for pen- and post-menopausal women, we summarize risk factors and interventions to improve menopausal health. Based on the available scientific literature and the global burden of disease endeavor, we have selected and herein describe the following top 11 key health issues, selected in terms of burden exerted in women's mortality, morbidity, disability and quality of life: cardiovascular disease, musculoskeletal disorders, cancer, cognitive decline and dementia, chronic obstructive pulmonary disease, diabetes mellitus, metabolic syndrome, depression, vasomotor symptoms, sleep disturbances and migraine. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
C1 [van Dijk, Gabriella M.; Kavousi, Maryam; Troup, Jenna; Franco, Oscar H.] Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands.
C3 Erasmus University Rotterdam; Erasmus MC
RP Franco, OH (corresponding author), Univ Med Ctr Rotterdam, Erasmus MC, Dept Epidemiol, Off NA29-16,POB 2040, NL-3000 CA Rotterdam, Netherlands.
EM o.franco@erasmusmc.nl
RI Franco, Óscar/ABE-2305-2020; Kavousi, Maryam/F-1174-2018
OI Kavousi, Maryam/0000-0001-5976-6519; Franco, Oscar/0000-0002-4606-4929
FU AXA Research Fund; Nestle Nutrition (Nestec Ltd.); Metagenics Inc.; AXA
FX Maryam Kavousi is supported by the AXA Research Fund. G.M. van Dijk, J.
   Troup and O.H. Franco work in ErasmusAGE, a center for aging research
   across the life course funded by Nestle Nutrition (Nestec Ltd.);
   Metagenics Inc.; and AXA. Nestle Nutrition (Nestec Ltd.); Metagenics
   Inc.; and AXA had no role in design and conduct of the study;
   collection, management, analysis, and interpretation of the data; and
   preparation, review or approval of the manuscript.
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NR 76
TC 70
Z9 75
U1 6
U2 53
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0378-5122
EI 1873-4111
J9 MATURITAS
JI Maturitas
PD JAN
PY 2015
VL 80
IS 1
BP 24
EP 30
DI 10.1016/j.maturitas.2014.09.013
PG 7
WC Geriatrics & Gerontology; Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Obstetrics & Gynecology
GA AZ1QU
UT WOS:000348013900004
PM 25449663
DA 2025-06-11
ER

PT J
AU Taylor, V
   Macdonald, K
   McKinnon, MC
   Joffe, RT
   MacQueen, GM
AF Taylor, Valerie
   Macdonald, Kathryn
   McKinnon, Margaret C.
   Joffe, Russell T.
   MacQueen, Glenda M.
TI Increased rates of obesity in first-presentation adults with mood
   disorders over the course of four-year follow-up
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE obesity; mood disorder; morality; first episode
ID METABOLIC SYNDROME; EATING BEHAVIOR; WEIGHT CHANGE; RATING-SCALE;
   BODY-WEIGHT; DEPRESSION; BIPOLAR; PREVALENCE; DYSLIPIDEMIA; ASSOCIATION
AB Background: Patients with mood disorders have higher rates of obesity than the general population. With respect to this, little is known regarding how patient look like prior to treatment or the rates of change.
   Objective: To identify changes in the rates of obesity in never-treated patients with mood disorder over 4 years of follow-up.
   Methods: Sixty-six never-treated patients with mood disorders were evaluated via clinical interview, symptom assessment and body mass index (BMI). Patients were followed 4 years. Population attributable risk (PAR%) was calculated.
   Results: Patients in underweight and normal weight groups fell by nearly 29%, with a corresponding increase in patients entering overweight and obese groups. Rates of PAR% increased to 16.0, a significant 5-point increase over baseline.
   Limitations: This study had a small sample size and the population was ethnically homogenous. BMI was used as a maker of weight and not waist circumference.
   Conclusions: Over 4 years there was a significant increase in BMI and the risk conferred by obesity. Shift from normal weight to overweight and obese is a significant risk for patients with a mood disorder and clinical programs should consider interventions that might ameliorate risk of this shift early in the course of the illness. (C) 2007 Elsevier B.V. All rights reserved.
C1 [Taylor, Valerie; Macdonald, Kathryn; McKinnon, Margaret C.; MacQueen, Glenda M.] McMaster Univ, Hamilton, ON, Canada.
   [Joffe, Russell T.] Univ Med & Dent New Jersey, Newark, NJ 07103 USA.
C3 McMaster University; Rutgers University System; Rutgers University New
   Brunswick; Rutgers University Biomedical & Health Sciences
RP MacQueen, GM (corresponding author), St Josephs Healthcare, Ctr Mt Hlth Serv, Mood Disorders Program, D104-F, Hamilton, ON L8N 3K7, Canada.
EM macqueng@mcmaster.ca
RI Taylor, Valerie/H-6242-2015; McKinnon, Margaret/AAT-5821-2021
OI Taylor, Valerie/0000-0002-8948-638X
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NR 41
TC 14
Z9 16
U1 0
U2 6
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD JUL
PY 2008
VL 109
IS 1-2
BP 127
EP 131
DI 10.1016/j.jad.2007.12.003
PG 5
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA 316YY
UT WOS:000256987300013
PM 18221791
DA 2025-06-11
ER

PT J
AU Rosero-Bixby, L
   Dow, WH
AF Rosero-Bixby, Luis
   Dow, William H.
TI Surprising SES Gradients in Mortality, Health, and Biomarkers in a Latin
   American Population of Adults
SO JOURNALS OF GERONTOLOGY SERIES B-PSYCHOLOGICAL SCIENCES AND SOCIAL
   SCIENCES
LA English
DT Article; Proceedings Paper
CT Annual Meeting of the Population-Association-of-America
CY MAR 29-31, 2007
CL New York, NY
SP Populat Assoc Amer
DE Aging; Biological markers; Costa Rica; Health; Mortality; Socioeconomic
   status
ID CUMULATIVE BIOLOGICAL RISK; SOCIOECONOMIC DIFFERENCES; UNITED-STATES; US
   ADULTS; DIFFERENTIALS; DETERMINANTS; LONGEVITY; EDUCATION
AB Background. To determine socioeconomic status (SES) gradients in the different dimensions of health among elderly Costa Ricans. Hypothesis: SES disparities in adult health are minimal in Costa Rican society.
   Methods. Data from the Costa Rican Study on Longevity and Healthy Aging study: 8,000 elderly Costa Ricans to determine mortality in the period 2000-2007 and a subsample of 3,000 to determine prevalence of several health conditions and biomarkers from anthropometry and blood and urine specimens.
   Results. The ultimate health indicator, mortality, as well as the metabolic syndrome, reveals that better educated and wealthier individuals are worse off. In contrast, quality of life-related measures such as functional and cognitive disabilities, physical frailty, and depression all clearly worsen with lower SES. Overall self-reported health (SRH) also shows a strong positive SES gradient. Traditional cardiovascular risk factors such as diabetes and cholesterol are not significantly related to SES, but hypertension and obesity are worse among high-SES individuals. Reflecting mixed SES gradients in behaviors, smoking and lack of exercise are more common among low SES, but high calorie diets are more common among high SES.
   Conclusions. Negative modern behaviors among high-SES groups may be reversing cardiovascular risks across SES groups, hence reversing mortality risks. But negative SES gradients in healthy years of life persist.
C1 [Rosero-Bixby, Luis] Univ Costa Rica, Cent Amer Populat Ctr, San Jose, Costa Rica.
   [Rosero-Bixby, Luis] Univ Costa Rica, Inst Hlth Res, San Jose, Costa Rica.
   [Dow, William H.] Univ Calif Berkeley, Sch Publ Hlth, Berkeley, CA 94720 USA.
C3 Universidad Costa Rica; Universidad Costa Rica; University of California
   System; University of California Berkeley
RP Rosero-Bixby, L (corresponding author), Univ Costa Rica, CCP, San Jose 2060, Costa Rica.
EM lrosero@ccp.ucr.ac.cr
OI Dow, William/0000-0002-4080-1668; Rosero-Bixby, Luis/0000-0002-3063-3111
FU National Institute on Aging [P30AG012839] Funding Source: NIH RePORTER;
   NIA NIH HHS [P30 AG012839] Funding Source: Medline; Wellcome Trust
   [072406] Funding Source: Medline
CR [Anonymous], 2005, STAT STAT SOFTW REL
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   [No title captured]
NR 37
TC 107
Z9 120
U1 0
U2 19
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1079-5014
EI 1758-5368
J9 J GERONTOL B-PSYCHOL
JI J. Gerontol. Ser. B-Psychol. Sci. Soc. Sci.
PD JAN
PY 2009
VL 64
IS 1
BP 105
EP 117
DI 10.1093/geronb/gbn004
PG 13
WC Geriatrics & Gerontology; Gerontology; Psychology; Psychology,
   Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI); Conference Proceedings Citation Index - Science (CPCI-S); Conference Proceedings Citation Index - Social Science &amp; Humanities (CPCI-SSH)
SC Geriatrics & Gerontology; Psychology
GA 419AD
UT WOS:000264190600014
PM 19196695
OA Green Published, hybrid, Green Submitted
DA 2025-06-11
ER

PT J
AU Vancampfort, D
   Mugisha, J
   Richards, J
   De Hert, M
   Probst, M
   Stubbs, B
AF Vancampfort, Davy
   Mugisha, James
   Richards, Justin
   De Hert, Marc
   Probst, Michel
   Stubbs, Brendon
TI Physical activity correlates in people living with HIV/AIDS: a
   systematic review of 45 studies
SO DISABILITY AND REHABILITATION
LA English
DT Review
DE Physical activity; exercise; physiotherapy; AIDS; HIV
ID HUMAN-IMMUNODEFICIENCY-VIRUS; HIV-INFECTED PATIENTS; QUALITY-OF-LIFE;
   METABOLIC SYNDROME; ANTIRETROVIRAL THERAPY; CARDIORESPIRATORY FITNESS;
   CARDIOVASCULAR RISK; ENERGY-EXPENDITURE; EXERCISE PROGRAM; OLDER-ADULTS
AB Purpose: Understanding barriers and facilitators of physical activity participation in persons living with HIV/AIDS is an essential first step in order to devise effective interventions. The present review provides a systematic quantitative review of the physical activity correlates in people with HIV/AIDS.
   Methods: Major electronic databases were searched till August 2016. Keywords included "physical activity" or "exercise" or "sports" and "AIDS" or "HIV".
   Results: Out of 55 correlates from 45 studies (N=13,167; mean age range=30.5-58.3years; 63.2% male) five consistent (i.e., reported in four or more studies) correlates were identified. Lower levels of physical activity were consistently associated with older age (6/10 studies), a lower educational level (6/7), a lower number of CD4 cells/mu l (7/11), exposure to antiviral therapy (4/6), and the presence of lipodystrophy (4/4). Other important barriers were the presence of bodily pain (2/2), depression (3/3), and opportunistic infections (3/4). Facilitators were a higher cardiorespiratory fitness level (3/3), a higher self-efficacy (2/2), more perceived benefits (2/2), and a better health motivation (3/3).
   Conclusions: The current review has elucidated that participation in physical activity by people with HIV/AIDS is associated with a range of complex factors which should be considered in rehabilitation programs.
C1 [Vancampfort, Davy; Probst, Michel] Univ Leuven, KU Leuven, Dept Rehabil Sci, Leuven, Belgium.
   [Vancampfort, Davy; De Hert, Marc] Univ Leuven, KU Leuven, Univ Psychiat Ctr KU Leuven, Leuven Kortenberg, Belgium.
   [Mugisha, James] Butabika Natl Referral & Mental Hlth Hosp, Kampala, Uganda.
   [Mugisha, James] Kyambogo Univ, Dept Sociol & Social Adm, Kampala, Uganda.
   [Richards, Justin] Univ Sydney, Sch Publ Hlth, Sydney, NSW, Australia.
   [Richards, Justin] Univ Sydney, Charles Perkins Ctr, Sydney, NSW, Australia.
   [Stubbs, Brendon] South London & Maudsley NHS Fdn Trust, Dept Physiotherapy, London, England.
   [Stubbs, Brendon] Kings Coll London, Dept Hlth Serv & Populat Res, Crespigny Pk, London, England.
C3 KU Leuven; KU Leuven; Kyambogo University; University of Sydney;
   University of Sydney; South London & Maudsley NHS Trust; University of
   London; King's College London
RP Vancampfort, D (corresponding author), Univ Leuven, KU Leuven, UPC KU Leuven, Campus Kortenberg, B-3070 Kortenberg, Belgium.
EM davy.vancampfort@kuleuven.be
RI De Hert, Marc/AAH-6090-2021; Probst, Michel/ABE-6137-2020; Vancampfort,
   Davy/AAD-1987-2019; Stubbs, Brendon/X-1904-2018; Stubbs,
   Brendon/C-5696-2015
OI Richards, Justin/0000-0003-4584-8614; De Hert, Marc/0000-0003-4255-5920;
   Mugisha, James/0000-0003-2084-8693; Stubbs, Brendon/0000-0001-7387-3791
FU Collaboration for Leadership in Applied Health Research and Care South
   London
FX This research received no specific grant from any funding agency in the
   public, commercial, or not-for-profit sectors. Brendon Stubbs was
   supported by the Collaboration for Leadership in Applied Health Research
   and Care South London theme. No sources of funding were used to assist
   in the preparation of this article.
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NR 105
TC 72
Z9 75
U1 0
U2 22
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0963-8288
EI 1464-5165
J9 DISABIL REHABIL
JI Disabil. Rehabil.
PY 2018
VL 40
IS 14
BP 1618
EP 1629
DI 10.1080/09638288.2017.1306587
PG 12
WC Rehabilitation
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Rehabilitation
GA GA7LD
UT WOS:000428516800002
PM 28325087
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Tokarek, J
   Gadzinowska, J
   Mlynarska, E
   Franczyk, B
   Rysz, J
AF Tokarek, Julita
   Gadzinowska, Joanna
   Mlynarska, Ewelina
   Franczyk, Beata
   Rysz, Jacek
TI What Is the Role of Gut Microbiota in Obesity Prevalence? A Few Words
   about Gut Microbiota and Its Association with Obesity and Related
   Diseases
SO MICROORGANISMS
LA English
DT Article
DE obesity; microbiota; dysbiosis; morbidities; gastrointestinal
   microbiome; probiotics; metabolic syndrome
ID ADIPOSE-TISSUE; INTESTINAL MICROBIOTA; CHILDHOOD OBESITY; MODULATION;
   RESISTIN; LINKS; DIET
AB Obesity is becoming the most dangerous lifestyle disease of our time, and its effects are already being observed in both developed and developing countries. The aim of this study was to investigate the impact of gut microbiota on the prevalence of obesity and associated morbidities, taking into consideration underlying molecular mechanisms. In addition to exploring the relationship between obesity and fecal microorganisms with their metabolites, the study also focused on the factors that would be able to stimulate growth and remodeling of microbiota. Assessed articles were carefully classified according to a predetermined criterion and were critically appraised and used as a basis for conclusions. The considered articles and reviews acknowledge that intestinal microbiota forms a multifunctional system that might significantly affect human homeostasis. It has been proved that alterations in the gut microbiota are found in obese and metabolically diseased patients. The imbalance of microbiome composition, such as changes in Bacteroidetes/Firmicutes ratio and presence of different species of genus Lactobacillus, might promote obesity and comorbidities (type 2 diabetes mellitus, hypertension, dyslipidemia, depression, obstructive sleep apnea). However, there are also studies that contradict this theory. Therefore, further well-designed studies are needed to improve the knowledge about the influence of microbiota, its metabolites, and probiotics on obesity.
C1 [Tokarek, Julita; Gadzinowska, Joanna; Mlynarska, Ewelina; Franczyk, Beata; Rysz, Jacek] Med Univ Lodz, Dept Nephrol Hypertens & Family Med, Ul Zeromskiego 113, PL-90549 Lodz, Poland.
C3 Medical University Lodz
RP Mlynarska, E (corresponding author), Med Univ Lodz, Dept Nephrol Hypertens & Family Med, Ul Zeromskiego 113, PL-90549 Lodz, Poland.
EM julita.tokarek@stud.umed.lodz.pl; joanna.gadzinowska@stud.umed.lodz.pl;
   emmlynarska@gmail.com; bfranczyk-skora@wp.pl; jacek.rysz@umed.lodz.pl
RI Franczyk, Beata/AAG-2657-2019; Rysz, Jacek/L-8313-2013
OI Franczyk, Beata/0000-0003-4060-8822; Gadzinowska,
   Joanna/0000-0002-7257-8552; Tokarek, Julita/0000-0003-4527-3355;
   Mlynarska, Ewelina/0000-0002-6799-4746; Rysz, Jacek/0000-0002-2757-6443
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NR 76
TC 31
Z9 32
U1 2
U2 51
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2076-2607
J9 MICROORGANISMS
JI Microorganisms
PD JAN
PY 2022
VL 10
IS 1
AR 52
DI 10.3390/microorganisms10010052
PG 17
WC Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Microbiology
GA YL6OJ
UT WOS:000746008100001
PM 35056501
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Chen, SZ
   Jiang, HT
   Liu, Y
   Hou, ZH
   Yue, YY
   Zhang, YQ
   Zhao, FY
   Xu, Z
   Li, YH
   Mou, XD
   Li, L
   Wang, TY
   Zhao, JJ
   Han, CY
   Sui, YX
   Wang, M
   Yang, Z
   Lu, Y
   Zhu, YF
   Li, JH
   Shen, XH
   Sun, F
   Chen, QS
   Chen, HX
   Yuan, YG
AF Chen, Suzhen
   Jiang, Haitang
   Liu, Yang
   Hou, Zhenhua
   Yue, Yingying
   Zhang, Yuqun
   Zhao, Fuying
   Xu, Zhi
   Li, Yinghui
   Mou, Xiaodong
   Li, Lei
   Wang, Tianyu
   Zhao, Jingjing
   Han, Chongyang
   Sui, Yuxiu
   Wang, Ming
   Yang, Zhong
   Lu, Yan
   Zhu, Yifeng
   Li, Jianhua
   Shen, Xinhua
   Sun, Fei
   Chen, Qingsong
   Chen, Huanxin
   Yuan, Yonggui
TI Combined serum levels of multiple proteins in tPA-BDNF pathway may aid
   the diagnosis of five mental disorders
SO SCIENTIFIC REPORTS
LA English
DT Article
ID NEUROTROPHIC FACTOR LEVELS; MAJOR DEPRESSIVE DISORDER; MOOD DISORDERS;
   ELECTROCONVULSIVE-THERAPY; ANTIPSYCHOTIC TREATMENT; INFLAMMATION
   MARKERS; METABOLIC SYNDROME; BIPOLAR DISORDER; PANIC DISORDER;
   RATING-SCALE
AB Mental disorders are severe, disabling conditions with unknown etiology and are commonly misdiagnosed when clinical symptomology criteria are solely used. Our previous work indicated that combination of serum levels of multiple proteins in tissue plasminogen activator (tPA)-brain-derived neurotrophic factor (BDNF) pathway improved accuracy of diagnosis of major depressive disorder (MDD). Here, we measured serum levels of tPA, plasminogen activator inhibitor-1 (PAI-1), BDNF, precursor-BDNF (proBDNF), tropomyosin-related kinase B (TrkB) and neurotrophin receptor p75 (p75NTR) in patients with paranoid schizophrenia (SZ, n = 34), MDD (n = 30), bipolar mania (BM, n = 30), bipolar depression (BD, n = 22), panic disorder (PD, n = 30), and healthy controls (HCs, n = 30) by Enzyme-linked immunosorbent assay kits. We used receiver operating characteristic (ROC) curve to analyze diagnostic potential of these proteins. We found, compared with HCs, that serum tPA and proBDNF were lower in SZ, BM and BD; TrkB was lower in SZ and BD; and p75NTR was declined in SZ and BM. ROC analysis showed that combined serum level of tPA, PAI-1, BDNF, proBDNF, TrkB and p75NTR was better than any single protein in accuracy of diagnosis and differentiation, suggesting that the combination of multiple serum proteins levels in tPA-BDNF pathway may have a potential for a diagnostic panel in mental disorders.
C1 [Chen, Suzhen; Jiang, Haitang; Hou, Zhenhua; Yue, Yingying; Zhang, Yuqun; Zhao, Fuying; Xu, Zhi; Li, Yinghui; Mou, Xiaodong; Li, Lei; Wang, Tianyu; Yuan, Yonggui] Southeast Univ, ZhongDa Hosp, Med Sch, Dept Psychosomat & Psychiat, Nanjing 210009, Jiangsu, Peoples R China.
   [Chen, Suzhen; Jiang, Haitang; Hou, Zhenhua; Yue, Yingying; Zhang, Yuqun; Zhao, Fuying; Xu, Zhi; Li, Yinghui; Mou, Xiaodong; Li, Lei; Wang, Tianyu; Yuan, Yonggui] Southeast Univ, Med Sch, Inst Psychosomat, Nanjing 210009, Jiangsu, Peoples R China.
   [Liu, Yang] Nanjing Med Univ, Brain Hosp, Inst Neuropsychiat, Nanjing 210029, Jiangsu, Peoples R China.
   [Zhao, Jingjing; Han, Chongyang; Sui, Yuxiu] Nanjing Med Univ, Brain Hosp, Dept Psychiat, Nanjing 210029, Jiangsu, Peoples R China.
   [Wang, Ming; Yang, Zhong] Third Peoples Hosp Changshu, Dept Psychiat, Suzhou 215500, Peoples R China.
   [Lu, Yan; Zhu, Yifeng] Fourth Peoples Hosp Zhangjiagang, Dept Psychiat, Suzhou 215600, Peoples R China.
   [Li, Jianhua; Shen, Xinhua] Third Peoples Hosp Huzhou, Dept Psychiat, Huzhou 313000, Peoples R China.
   [Sun, Fei; Chen, Qingsong] Second Peoples Hosp Jingjiang, Dept Psychiat, Taizhou 214500, Peoples R China.
   [Chen, Huanxin] Minist Educ, Key Lab Cognit & Personal, Chongqing 400175, Peoples R China.
   [Chen, Huanxin] Southwest Univ, Sch Psychol, Chongqing 400175, Peoples R China.
C3 Southeast University - China; Southeast University - China; Nanjing
   Medical University; Nanjing Medical University; Ministry of Education -
   China; Southwest University - China
RP Yuan, YG (corresponding author), Southeast Univ, ZhongDa Hosp, Med Sch, Dept Psychosomat & Psychiat, Nanjing 210009, Jiangsu, Peoples R China.; Yuan, YG (corresponding author), Southeast Univ, Med Sch, Inst Psychosomat, Nanjing 210009, Jiangsu, Peoples R China.
EM yygylh2000@sina.com
RI chen, qing-song/C-2210-2011; Chen, Suzhen/JNS-2516-2023; Yuan,
   Yonggui/JAN-6160-2023; Wang, Tianyu/AAT-6941-2021
OI Yuan, Yonggui/0000-0001-6496-3998
FU National Natural Science Foundation of China [81071101, 81571330,
   81301167]; Fundamental Research Funds for the Central Universities
   (Southeast University) [2242016K41053]
FX We are grateful to all the participants in this study. This work was
   supported by National Natural Science Foundation of China (grant number
   81071101 and 81571330, Yonggui Yuan, and grant number 81301167, Zhi Xu)
   and the Fundamental Research Funds for the Central Universities
   (Southeast University, grant number 2242016K41053).
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NR 53
TC 31
Z9 31
U1 2
U2 16
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD JUL 31
PY 2017
VL 7
AR 6871
DI 10.1038/s41598-017-06832-6
PG 9
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Science & Technology - Other Topics
GA FX3JW
UT WOS:000425969300004
PM 28761093
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Lluís, L
   Taltavull, N
   Muñoz-Cortés, M
   Sánchez-Martos, V
   Romeu, M
   Giralt, M
   Molinar-Toribio, E
   Torres, JL
   Pérez-Jiménez, J
   Pazos, M
   Méndez, L
   Gallardo, JM
   Medina, I
   Nogués, MR
AF Lluis, Laura
   Taltavull, Nuria
   Munoz-Cortes, Monica
   Sanchez-Martos, Vanesa
   Romeu, Marta
   Giralt, Montse
   Molinar-Toribio, Eunice
   Torres, Josep Lluis
   Perez-Jimenez, Jara
   Pazos, Manuel
   Mendez, Lucia
   Gallardo, Jose M.
   Medina, Isabel
   Nogues, M. Rosa
TI Protective effect of the omega-3 polyunsaturated fatty acids:
   Eicosapentaenoic acid/Docosahexaenoic acid 1:1 ratio on cardiovascular
   disease risk markers in rats
SO LIPIDS IN HEALTH AND DISEASE
LA English
DT Article
DE Omega-3 polyunsaturated fatty acids (PUFA); Eicosapentaenoic acid (EPA);
   Docosahexaenoic acid (DHA); Fish oils; Oxidative stress; Antioxidant
   status; Cardiovascular disease risk; Insulin resistance
ID FISH-OIL; METABOLIC SYNDROME; OXIDATIVE STRESS; SUPPLEMENTATION; LIVER;
   TRIACYLGLYCEROLS; INCREASES; CATALASE; WEIGHT; SERUM
AB Background: High consumption of fish carries a lower risk of cardiovascular disease as a consequence of dietary omega-3 long chain polyunsaturated fatty acid (n-3 PUFA; especially EPA and DHA) content. A controversy exists about the component/s responsible of these beneficial effects and, in consequence, which is the best proportion between both fatty acids. We sought to determine, in healthy Wistar rats, the proportions of EPA and DHA that would induce beneficial effects on biomarkers of oxidative stress, and cardiovascular disease risk.
   Methods: Female Wistar rats were fed for 13 weeks with 5 different dietary supplements of oils; 3 derived from fish (EPA/DHA ratios of 1: 1, 2: 1, 1: 2) plus soybean and linseed as controls. The activities of major antioxidant enzymes (SOD, CAT, GPX, and GR) were determined in erythrocytes and liver, and the ORAC test was used to determine the antioxidant capacity in plasma. Also measured were: C reactive protein (CRP), endothelial dysfunction (sVCAM and sICAM), prothrombotic activity (PAI-1), lipid profile (triglycerides, cholesterol, HDLc, LDLc, Apo-A1, and Apo-B100), glycated haemoglobin and lipid peroxidation (LDL-ox and MDA values).
   Results: After three months of nutritional intervention, we observed statistically significant differences in the ApoB100/ApoA1 ratio, glycated haemoglobin, VCAM-1, SOD and GPx in erythrocytes, ORAC values and LDL-ox. Supplementation with fish oil derived omega-3 PUFA increased VCAM-1, LDL-ox and plasma antioxidant capacity (ORAC). Conversely, the ApoB100/ApoA1 ratio and percentage glycated haemoglobin decreased.
   Conclusions: Our results showed that a diet of a 1: 1 ratio of EPA/DHA improved many of the oxidative stress parameters (SOD and GPx in erythrocytes), plasma antioxidant capacity (ORAC) and cardiovascular risk factors (glycated haemoglobin) relative to the other diets.
C1 [Lluis, Laura; Taltavull, Nuria; Munoz-Cortes, Monica; Sanchez-Martos, Vanesa; Romeu, Marta; Giralt, Montse; Nogues, M. Rosa] Univ Rovira & Virgili, Fac Med & Hlth Sci, Pharmacol Unit, Reus 43201, Spain.
   [Molinar-Toribio, Eunice; Torres, Josep Lluis; Perez-Jimenez, Jara] Inst Adv Chem Catalonia CSIC IQAC CSIC, Barcelona, Spain.
   [Pazos, Manuel; Mendez, Lucia; Gallardo, Jose M.; Medina, Isabel] Inst Marine Research CSIC IIM CSIC, Vigo, Spain.
C3 Universitat Rovira i Virgili; Consejo Superior de Investigaciones
   Cientificas (CSIC); CSIC - Centro de Investigacion y Desarrollo Pascual
   Vila (CID-CSIC); CSIC - Instituto de Quimica Avanzada de Cataluna
   (IQAC); Consejo Superior de Investigaciones Cientificas (CSIC); CSIC -
   Instituto de Investigaciones Marinas (IIM)
RP Nogués, MR (corresponding author), Univ Rovira & Virgili, Fac Med & Hlth Sci, Pharmacol Unit, Sant Llorenc 21, Reus 43201, Spain.
EM mariarosa.nogues@urv.cat
RI Perez-Jimenez, Jara/B-3989-2009; ROMEU, MARTA/O-7129-2019; MEDINA,
   ISABEL/AAL-4012-2021; Nogués, M./ABH-5645-2020; Pazos,
   Manuel/N-5007-2014; Giralt, Montserrat/I-3905-2015; Mendez,
   Lucia/T-7016-2017; Torres, Josep/N-7256-2013
OI Mendez, Lucia/0000-0002-9711-2994; Torres, Josep/0000-0002-5072-8265
FU Spanish Ministry of Science and Innovation [AGL2009-12374-C03-01,
   AGL2009-12374-C03-02, AGL2009-12374-C03-03]; Spanish Ministry of Science
   and Innovation and Xunta de Galicia; Panamanian Government
   (SENACYT/IFARHU); Instituto de Salud Carlos III for a Sara Borrell
FX This investigation was supported, in part, by the Spanish Ministry of
   Science and Innovation (Grants AGL2009-12374-C03-01,-02 and -03). We
   acknowledge the Spanish Ministry of Science and Innovation and Xunta de
   Galicia for the post-graduate fellowship to L. M. and the postdoctoral
   "Isidro Parga Pondal" contract to M. P.; the Panamanian Government
   (SENACYT/IFARHU) for the postgraduate fellowship to EMT and the
   Instituto de Salud Carlos III for a Sara Borrell postdoctoral contract
   to JP-J.
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NR 32
TC 7
Z9 7
U1 0
U2 0
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1476-511X
J9 LIPIDS HEALTH DIS
JI Lipids Health Dis.
PD OCT 1
PY 2013
VL 12
DI 10.1186/1476-511X-12-140
PG 8
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA 244RK
UT WOS:000326406900001
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Abedi, A
   Ghobadi, H
   Sharghi, A
   Iranpour, S
   Fazlzadeh, M
   Aslani, MR
AF Abedi, Ali
   Ghobadi, Hassan
   Sharghi, Afshan
   Iranpour, Sohrab
   Fazlzadeh, Mehdi
   Aslani, Mohammad Reza
TI Effect of saffron supplementation on oxidative stress markers (MDA, TAC,
   TOS, GPx, SOD, and pro-oxidant/antioxidant balance): An updated
   systematic review and meta-analysis of randomized placebo-controlled
   trials
SO FRONTIERS IN MEDICINE
LA English
DT Review
DE Crocus sativus; oxidative stress; meta-analysis; saffron;
   malondialdehyde; total antioxidant capacity
ID CROCUS-SATIVUS L.; PIG TRACHEAL CHAINS; DOUBLE-BLIND; METABOLIC
   SYNDROME; ALZHEIMERS-DISEASE; TRIPLE-BLIND; ANTIOXIDANT; MODERATE; MILD;
   INFLAMMATION
AB Introduction This study aimed to perform an updated systematic review and meta-analysis to evaluate the effectiveness of saffron supplementation on oxidative stress markers [malondialdehyde (MDA), total antioxidant capacity (TAC), total oxidant status (TOS), glutathione peroxidase (GPx), superoxide dismutase (SOD), and prooxidant/antioxidant balance (PAB)] in randomized controlled trials (RCTs).Methods We searched PubMed/Medline, Web of Science, Scopus, Cochrane CENTRAL, and Google Scholar until December 2022. Trial studies investigating the effects of oral saffron supplements on MDA, TAC, TOS, GPx, SOD, and PAB concentrations were included in the study. To analyze the results, mean differences (SMD) and 95% confidence intervals (CI) were pooled using a random effects model. Heterogeneity was assessed using the Cochrane Q and I-2 values. Sixteen cases were included in the meta-analysis (468 and 466 subjects in the saffron and control groups, respectively).Results It was found that saffron consumption caused a significant decrease in MDA (SMD: -0.322; 95% CI: -0.53, -0.16; I-2 = 32.58%) and TOS (SMD: -0.654; 95% CI: -1.08, -0.23; I-2 = 68%) levels as well as a significant increase in TAC (SMD: 0.302; 95% CI: 0.13, 0.47; I-2 = 10.12%) and GPx (SMD: 0.447; 95% CI: 0.10, 0.80; I-2 = 35%). Subgroup analysis demonstrated a significant reduction in MDA levels in studies with a saffron dosage of > 30 mg/day, age of < 50 years, and study duration of < 12 weeks. Among the limitations of the study, we can point out that the studies were from Iran, the different nature of the diseases included, and were not considered of some potential confounders such as smoking, physical activity, and diet in the studies.Discussion In summary, the results showed that saffron has beneficial effects on oxidative stress markers.
C1 [Abedi, Ali] Ardabil Univ Med Sci, Fac Med, Dept Physiol, Ardebil, Iran.
   [Ghobadi, Hassan; Aslani, Mohammad Reza] Ardabil Univ Med Sci, Lung Dis Res Ctr, Ardebil, Iran.
   [Ghobadi, Hassan] Ardabil Univ Med Sci, Fac Med, Dept Internal Med, Ardebil, Iran.
   [Sharghi, Afshan; Iranpour, Sohrab] Ardabil Univ Med Sci, Fac Med, Dept Community Med, Ardebil, Iran.
   [Fazlzadeh, Mehdi] Ardabil Univ Med Sci, Social Determinants Hlth Res Ctr, Ardebil, Iran.
   [Aslani, Mohammad Reza] Mashhad Univ Med Sci, Appl Biomed Res Ctr, Mashhad, Iran.
C3 Ardabil University of Medical Sciences; Ardabil University of Medical
   Sciences; Ardabil University of Medical Sciences; Ardabil University of
   Medical Sciences; Ardabil University of Medical Sciences; Mashhad
   University of Medical Sciences
RP Aslani, MR (corresponding author), Ardabil Univ Med Sci, Lung Dis Res Ctr, Ardebil, Iran.; Aslani, MR (corresponding author), Mashhad Univ Med Sci, Appl Biomed Res Ctr, Mashhad, Iran.
EM mraslani105@yahoo.com
RI Iranpour, sohrab/ABH-1858-2021; sharghi, afshan/K-4155-2018; ghobadi,
   hassan/J-5241-2017; Abedi, Ali/R-7384-2017; fazlzadeh,
   mehdi/J-6218-2017; Aslani, Mohammad Reza/J-3566-2017
OI Aslani, Mohammad Reza/0000-0003-1519-7611
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NR 65
TC 29
Z9 31
U1 3
U2 15
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 2296-858X
J9 FRONT MED-LAUSANNE
JI Front. Med.
PD FEB 1
PY 2023
VL 10
AR 1071514
DI 10.3389/fmed.2023.1071514
PG 13
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 8Z6DF
UT WOS:000933465800001
PM 36817799
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Wang, HY
   Ai, J
   Shopit, A
   Niu, MY
   Ahmed, N
   Tesfaldet, T
   Tang, ZY
   Li, XD
   Jamalat, Y
   Chu, P
   Peng, JY
   Ma, XD
   Qaed, E
   Han, GZ
   Zhang, WS
   Wang, J
   Tang, ZY
AF Wang, Hongyan
   Ai, Jie
   Shopit, Abdullah
   Niu, Mengyue
   Ahmed, Nisar
   Tesfaldet, Tsehaye
   Tang, Zhongyuan
   Li, Xiaodong
   Jamalat, Yazeed
   Chu, Peng
   Peng, Jinyong
   Ma, Xiaodong
   Qaed, Eskandar
   Han, Guozhu
   Zhang, Weisheng
   Wang, Jun
   Tang, Zeyao
TI Protection of pancreatic β-cell by phosphocreatine through mitochondrial
   improvement via the regulation of dual AKT/IRS-1/GSK-3β and STAT3/Cyp-D
   signaling pathways
SO CELL BIOLOGY AND TOXICOLOGY
LA English
DT Article
DE Pancreatic beta-cells; Methylglyoxal; Phosphocreatine; Mitochondria;
   Cyclophilin D
ID INDUCED CYTOTOXICITY; OXIDATIVE STRESS; APOPTOSIS; METHYLGLYOXAL;
   ACTIVATION; INJURY
AB Diabetes mellitus (DM) is a metabolic syndrome, caused by insufficient insulin secretion or insulin resistance (IR). DM enhances oxidative stress and induces mitochondrial function in different kinds of cell types, including pancreatic beta-cells. Our previous study has showed phosphocreatine (PCr) can advance the mitochondrial function through enhancing the oxidative phosphorylation and electron transport ability in mitochondria damaged by methylglyoxal (MG). Our aim was to explore the potential role of PCr as a molecule to protect mitochondria from diabetes-induced pancreatic beta-cell injury with insulin secretion deficiency or IR through dual AKT/IRS-1/GSK-3 beta and STAT3/Cyclophilin D (Cyp-D) signaling pathways. MG-induced INS-1 cell viability, apoptosis, mitochondrial division and fusion, the morphology, and function of mitochondria were suppressed. Flow cytometry was used to detect the production of intracellular reactive oxygen species (ROS) and the changes of intracellular calcium, and the respiratory function was measured by oxygraph-2k. The expressions of AKT, IRS-1, GSK-3 beta, STAT3, and Cyp-D were detected using Western blot. The result showed that the oxidative stress-related kinases were significantly restored to the normal level after the pretreatment with PCr. Moreover, PCr pretreatment significantly inhibited cell apoptosis, decreased intracellular calcium, and ROS production, and inhibited mitochondrial division and fusion, and increased ATP synthesis damaged by MG in INS-1 cells. In addition, pretreatment with PCr suppressed Cytochrome C, p-STAT3, and Cyp-D expressions, while increased p-AKT, p-IRS-1, p-GSK-3 beta, caspase-3, and caspase-9 expressions. In conclusion, PCr has protective effect on INS-1 cells in vitro and in vivo, relying on AKT mediated STAT3/ Cyp-D pathway to inhibit oxidative stress and restore mitochondrial function, signifying that PCr might become an emerging candidate for the cure of diabetic pancreatic cancer beta-cell damage.
C1 [Wang, Hongyan; Ai, Jie; Shopit, Abdullah; Niu, Mengyue; Ahmed, Nisar; Tesfaldet, Tsehaye; Jamalat, Yazeed; Chu, Peng; Peng, Jinyong; Ma, Xiaodong; Qaed, Eskandar; Han, Guozhu; Tang, Zeyao] Dalian Med Univ, Acad Integrated Med, 9 Western Sect,Lvshun South St, Dalian 116044, Peoples R China.
   [Wang, Hongyan; Ai, Jie; Shopit, Abdullah; Niu, Mengyue; Ahmed, Nisar; Tesfaldet, Tsehaye; Jamalat, Yazeed; Chu, Peng; Peng, Jinyong; Ma, Xiaodong; Qaed, Eskandar; Han, Guozhu; Tang, Zeyao] Dalian Med Univ, Coll Pharm, Dept Pharmacol, 9 Western Sect,Lvshun South St, Dalian 116044, Peoples R China.
   [Tang, Zhongyuan] Dept Jilin Univ, Changchun, Peoples R China.
   [Li, Xiaodong] Dalian Med Univ, Clin Coll 2, Dalian, Peoples R China.
   [Zhang, Weisheng] Dalian Med Univ, Clin Coll 1, 9 Western Sect,Lvshun South St, Dalian 116044, Peoples R China.
   [Wang, Jun] Dalian Med Univ, Dept Pathophysiol, 9 Western Sect,Lvshun South St, Dalian 116044, Peoples R China.
C3 Dalian Medical University; Dalian Medical University; Dalian Medical
   University; Dalian Medical University; Dalian Medical University
RP Tang, ZY (corresponding author), Dalian Med Univ, Acad Integrated Med, 9 Western Sect,Lvshun South St, Dalian 116044, Peoples R China.; Tang, ZY (corresponding author), Dalian Med Univ, Coll Pharm, Dept Pharmacol, 9 Western Sect,Lvshun South St, Dalian 116044, Peoples R China.; Zhang, WS (corresponding author), Dalian Med Univ, Clin Coll 1, 9 Western Sect,Lvshun South St, Dalian 116044, Peoples R China.; Wang, J (corresponding author), Dalian Med Univ, Dept Pathophysiol, 9 Western Sect,Lvshun South St, Dalian 116044, Peoples R China.
EM 11111210027@fudan.edu.cn; Junwangw@yahoo.com; zeyaotang@163.com
RI Tang, Zeyao/C-5204-2018; Shopit, Abdullah/AAV-2720-2020
OI Shopit, Abdullah/0000-0003-1454-2970; Qaed, Eskandar/0000-0002-4624-9341
FU Natural Science Foundation of China [30772601]; University Innovation
   Team Project Foundation of Education Department of Liaoning Province
   [LT2013019]
FX This work was financially supported by the Natural Science Foundation of
   China (30772601) and the University Innovation Team Project Foundation
   of Education Department of Liaoning Province (LT2013019).
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NR 45
TC 13
Z9 13
U1 2
U2 12
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0742-2091
EI 1573-6822
J9 CELL BIOL TOXICOL
JI Cell Biol. Toxicol.
PD JUN
PY 2022
VL 38
IS 3
BP 531
EP 551
DI 10.1007/s10565-021-09644-7
EA AUG 2021
PG 21
WC Cell Biology; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Toxicology
GA 2D8JQ
UT WOS:000690715600001
PM 34455488
DA 2025-06-11
ER

PT J
AU Cho, H
   Shin, J
   Choi, JK
AF Cho, Hana
   Shin, Jinyoung
   Choi, Jae Kyung
TI Serum Lipid Levels and Suicidal Ideation of Adults: A Cross-Sectional
   Study Using the Korea National Health and Nutrition Examination Survey
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Article
DE low-density lipoprotein; household income; education level; suicidality;
   sex
ID DENSITY-LIPOPROTEIN CHOLESTEROL; SOCIOECONOMIC-STATUS; METABOLIC
   SYNDROME; FOLLOW-UP; PROGRAM; DYSLIPIDEMIA; METAANALYSIS; IMPULSIVITY;
   DISORDERS; MORTALITY
AB Cholesterol plays a crucial role in the brain, which suggests that changes in its concentration levels may have an impact on the central nervous system. To examine the association between serum lipid levels and suicidal ideation according to sex, we performed a cross-sectional study using data from the Korea National Health and Nutrition Examination Survey 2014-2018. A total of 13,772 adults 19 years or older were analyzed. The ninth item of the Patient Health Questionnaire was used to evaluate the suicidal ideation of participants. After sorting by sex, a complex logistic regression was performed to measure the association between serum lipid indicators and suicidal ideation. The analysis adjusted for age, body mass index, smoking, heavy drinking, regular exercise, household income, education level, dyslipidemia medication, depression, and chronic diseases. Compared to the intermediated category, the lowest range of low-density lipoprotein cholesterol (LDL-C; <100 mg/dL) was associated with increased suicidal ideation in men (odds ratio [OR] = 1.97; 95% confidence interval [CI]: 1.30-3.01). The association between lipid levels and suicidal ideation was not clear in women. We found an association between lower LDL-C levels and an increased risk of suicidal ideation among Korean men aged 19 years or older.
C1 [Cho, Hana; Shin, Jinyoung; Choi, Jae Kyung] Konkuk Univ, Sch Med, Dept Family Med, Med Ctr, Seoul 05030, South Korea.
C3 Konkuk University; Konkuk University Medical Center
RP Shin, J (corresponding author), Konkuk Univ, Sch Med, Dept Family Med, Med Ctr, Seoul 05030, South Korea.
EM 20210100@kuh.ac.kr; jyshin@kuh.ac.kr; cjk@kuh.ac.kr
OI Shin, Jinyoung/0000-0001-9558-1853; Choi, Jaekyung/0000-0002-0875-7505
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NR 50
TC 5
Z9 5
U1 2
U2 3
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD JUL
PY 2023
VL 12
IS 13
AR 4285
DI 10.3390/jcm12134285
PG 11
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA M2JU4
UT WOS:001028503900001
PM 37445320
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Wiebe, N
   Stueck, A
   Mcleod, M
AF Wiebe, Nicole
   Stueck, Ashley
   Mcleod, Magnus
TI Steatotic liver disease arising in an asymptomatic 20-year-old man with
   panhypopituitarism and elevated transaminases
SO CANADIAN LIVER JOURNAL
LA English
DT Article
DE growth hormone deficiency; fibrosis; panhypopituitarism; Rathke cleft
   cyst; steatohepatitis; steatotic liver disease
ID GROWTH-HORMONE REPLACEMENT
AB Background: Steatotic liver disease (SLD) may be caused by cardiometabolic risk factors, drugs/toxins, viral hepatitis, genetic diseases, malnutrition, or panhypopituitarism. SLD can advance to steatohepatitis with resulting lipid accumulation, inflammation, and hepatocellular damage. SLD is associated with pituitary dysfunction, in particular growth hormone deficiency, as insulin resistance leads to lipid buildup and oxidative stress. Growth hormone replacement may improve liver steatosis and fibrosis in patients with hypopituitarism.Case: We report a case of a 20-year-old man who was referred to Hepatology with abnormal liver enzymes. He had panhypopituitarism from a resected pituitary mass, for which he was treated with levothyroxine, hydrocortisone, growth hormone, and testosterone. He presented with elevated liver enzymes, normal liver function, obesity, dyslipidemia, and had no extrahepatic manifestations of chronic liver disease. Work-up for secondary causes of liver disease, including infectious, autoimmune, drug-induced, and genetic causes, were negative. An abdominal ultrasound revealed moderate hepatic steatosis with mild hepatomegaly and splenomegaly. His liver enzymes remained elevated, and his biochemical liver function remained normal despite withdrawal of hepatotoxic medications. Liver biopsy showed grade II/III steatohepatitis with stage III-IV fibrosis. The biopsy results suggested that panhypopituitarism, with growth hormone deficiency and related metabolic dysfunction, caused his liver disease.Conclusions: This is a unique case of an aggressive form of SLD due to panhypopituitarism, and treating growth hormone deficiency with hormone replacement did not improve liver enzymes or liver damage. Physicians should recognize SLD as a serious complication of panhypopituitarism and resulting growth hormone deficiency and follow patients closely given the risk of disease progression.
C1 [Wiebe, Nicole] Dalhousie Univ, Dept Med, Halifax, NS, Canada.
   [Stueck, Ashley] Dalhousie Univ, Dept Pathol, Halifax, NS, Canada.
   [Mcleod, Magnus] Hlth PEI, Charlottetown, PE, Canada.
C3 Dalhousie University; Dalhousie University
RP Mcleod, M (corresponding author), 51 Lantern Crescent,Price Edward Isl, Cornwall, PE C05 1H8, Canada.
EM magnusmcleod@ihis.org
RI Stueck, Ashley/AFJ-8257-2022
CR Adams LA, 2004, HEPATOLOGY, V39, P909, DOI 10.1002/hep.20140
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NR 18
TC 0
Z9 0
U1 0
U2 0
PU UNIV TORONTO PRESS INC
PI TORONTO
PA JOURNALS DIVISION, 5201 DUFFERIN ST, DOWNSVIEW, TORONTO, ON M3H 5T8,
   CANADA
EI 2561-4444
J9 CAN LIVER J
JI Can. Liver J.
PD DEC 19
PY 2024
VL 7
IS 4
BP 511
EP 516
DI 10.3138/canlivj-2024-0030
PG 6
WC Gastroenterology & Hepatology
WE Emerging Sources Citation Index (ESCI)
SC Gastroenterology & Hepatology
GA Q1S2J
UT WOS:001382561500006
DA 2025-06-11
ER

PT J
AU Stratigou, T
   Dalamaga, M
   Antonakos, G
   Marinou, I
   Vogiatzakis, E
   Christodoulatos, GS
   Karampela, I
   Papavassiliou, AG
AF Stratigou, Theodora
   Dalamaga, Maria
   Antonakos, Georgios
   Marinou, Ioanna
   Vogiatzakis, Evaggelos
   Christodoulatos, Gerasimos Socrates
   Karampela, Irene
   Papavassiliou, Athanasios G.
TI Hyperirisinemia is independently associated with subclinical
   hypothyroidism: correlations with cardiometabolic biomarkers and risk
   factors
SO ENDOCRINE
LA English
DT Article
DE Adipokine; Cardiovascular; Irisin; Myokine; Subclinical hypothyroidism;
   Thyroid
ID BROWN ADIPOSE-TISSUE; CIRCULATING IRISIN LEVELS; CORONARY-HEART-DISEASE;
   THYROID-HORMONE; BREAST-CANCER; MESSENGER-RNA; SERUM; ADIPONECTIN;
   FNDC5; METABOLISM
AB Irisin, a newly discovered adipo-myokine, is implicated in the modulation of the adipose phenotype, increasing energy expenditure and ameliorating systemic metabolism. Our aim was to investigate circulating irisin in subclinical hypothyroidism (SH) and study its associations with cardiometabolic risk factors.
   In a large case-control study, serum irisin, insulin resistance and lipid parameters, classic adipokines, inflammatory and hepatic biomarkers, and cardiovascular risk factors were determined in 120 consecutive patients with SH and 120 healthy controls matched on age, gender, and date of blood draw. Sixteen patients with SH received L-T4 treatment and, after 6 months, serum irisin and other biomarkers were assessed.
   SH cases exhibited significantly higher circulating irisin than controls (p < 0.001). In all participants, irisin was positively associated with TSH, anti-TG, HOMA-IR, C-peptide, lipid and inflammatory biomarkers, leptin, and cardiovascular risk factors, including Framigham score and apolipoprotein B/apolipoprotein A-I. Irisin was negatively correlated with adiponectin, HDL-C, and thyroid hormones. Serum irisin was independently associated with SH, above and beyond body mass index and cardiometabolic factors (p = 0.02). TSH was an independent predictor of circulating irisin (p = 0.003). L-T4 therapy did not reverse considerably the hyperirisinemic status in treated SH patients (p = 0.09).
   Irisin may represent an adipo-myokine counterbalancing a potential, gradual deterioration of lipid metabolism and insulin sensitivity in SH as well as reflecting a protective compensatory mechanism against oxidative muscle and thyroid cell stress. More mechanistic and prospective studies shedding light on the pathogenetic role of irisin in SH are needed to confirm and extend these data.
C1 [Stratigou, Theodora; Dalamaga, Maria; Christodoulatos, Gerasimos Socrates; Papavassiliou, Athanasios G.] Natl & Kapodistrian Univ Athens, Sch Med, Dept Biol Chem, 75 Mikras Asias St, Athens 11527, Greece.
   [Stratigou, Theodora] Evangelismos Gen Hosp Athens, Dept Endocrinol, 45-47 Ypsilantou St, Athens 10676, Greece.
   [Antonakos, Georgios] Natl & Kapodistrian Univ Athens, Attikon Gen Univ Hosp, Sch Med, Lab Clin Biochem, 1 Rimini St, Athens 12462, Greece.
   [Marinou, Ioanna; Vogiatzakis, Evaggelos] Sotiria Gen Hosp, Microbiol Lab, 152 Mesoge Ave, Athens 11527, Greece.
   [Karampela, Irene] Natl & Kapodistrian Univ Athens, Attikon Gen Univ Hosp, Sch Med, Dept Internal Med, 1 Rimini St, Athens 12462, Greece.
C3 National & Kapodistrian University of Athens; Athens Medical School;
   National & Kapodistrian University of Athens; Athens Medical School;
   University Hospital Attikon; University Hospital Attikon; Athens Medical
   School; National & Kapodistrian University of Athens
RP Dalamaga, M (corresponding author), Natl & Kapodistrian Univ Athens, Sch Med, Dept Biol Chem, 75 Mikras Asias St, Athens 11527, Greece.
EM madalamaga@med.uoa.gr
RI Dalamaga, Maria/A-4041-2013; Karampela, Irene/AAE-6235-2021
OI Papavassiliou, Athanasios/0000-0001-5803-4527; Dalamaga,
   Maria/0000-0002-7008-388X; Karampela, Irene/0000-0001-6912-4042
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NR 45
TC 40
Z9 40
U1 0
U2 12
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1355-008X
EI 1559-0100
J9 ENDOCRINE
JI Endocrine
PD JUL
PY 2018
VL 61
IS 1
BP 83
EP 93
DI 10.1007/s12020-018-1550-3
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA GJ2UQ
UT WOS:000435129400014
PM 29455364
DA 2025-06-11
ER

PT J
AU Di Renzo, L
   Galvano, F
   Orlandi, C
   Bianchi, A
   Di Giacomo, C
   La Fauci, L
   Acquaviva, R
   De Lorenzo, A
AF Di Renzo, Laura
   Galvano, Fabio
   Orlandi, Carmine
   Bianchi, Alessia
   Di Giacomo, Claudia
   La Fauci, Luca
   Acquaviva, Rosaria
   De Lorenzo, Antonino
TI Oxidative Stress in Normal-Weight Obese Syndrome
SO OBESITY
LA English
DT Article
ID BODY-COMPOSITION; METABOLIC SYNDROME; GENE POLYMORPHISM; ADIPOSE-TISSUE;
   OXIDANT STRESS; GLUTATHIONE; MECHANISMS; BIOMARKERS; WOMEN; FAT
AB The normal-weight obese (NWO) syndrome was identified in women whose body weight (BW) and BMI are normal but whose fat mass (FM) is >30%. In these subjects, an early inflammatory status has been demonstrated. The aim was to verify whether oxidative stress occurs in NWO. Sixty age-matched white Italian women were studied and subdivided as follows: 20 normal-weight individuals (NW) (BMI <25 kg/m(2); FM% <30%); 20 NWO (BMI <25 kg/m(2); FM% >30%); 20 preobese-obese (OB) (BMI >25 kg/m(2); FM% >30%). Anthropometric, body composition (by dual-energy X-ray absorptiometry) variables, plasma levels of some cytokines, reduced glutathione (GSH), lipid hydroperoxide (LOOH), nitric oxide (NO) metabolites (NO2-/NO3-), antioxidant nonproteic capacity (ANPC) were measured and compared between groups. Glucose and lipid metabolism parameters were assessed. GSH and NO2-/NO3- levels resulted lower in OB and NWO compared to NW (P < 0.01). LOOH levels resulted higher in OB and NWO (P < 0.01). ANPC in NWO was lower than NW but higher with respect to OB (P < 0.01). Correlation analysis revealed strong associations between GSH levels and BW, BMI, FM% (R = -0.45, at least P < 0.05); waist circumference (W) (R = -0.33, P < 0.05); FFM% (R = 0.45, P < 0.01); IL-1 alpha, IL-6, IL-10, IL-15 (R = -0.39, -0.33, -0.36 -0.34, respectively, P < 0.05); triglycerides (R = -0.416, P < 0.05). LOOH levels were negatively related to FFM% (R = -0.413, P < 0.05) and positively to FM%, IL-15, TNF-alpha, insulin, total cholesterol, low-density lipoprotein cholesterol, and triglycerides (R = 0.408, R = 0.502, R = 0.341, R = 0.412, R = 0.4036, R = 0.405, R = 0.405, respectively, P < 0.05). The study clearly indicates that NWO, besides being in early inflammatory status, are contextually exposed to an oxidative stress related to metabolic abnormalities occurring in obesity.
C1 [Di Renzo, Laura; Orlandi, Carmine; Bianchi, Alessia; De Lorenzo, Antonino] Univ Roma Tor Vergata, Dept Neurosci, Div Human Nutr, Rome, Italy.
   [Di Renzo, Laura; De Lorenzo, Antonino] Natl Inst Mediterranean Diet & Nutrigenom, INDiM, Reggio Di Calabria, Italy.
   [Galvano, Fabio; Di Giacomo, Claudia; La Fauci, Luca; Acquaviva, Rosaria] Univ Catania, Dept Biol Chem, Div Med Chem & Mol Biol, Catania, Italy.
C3 University of Rome Tor Vergata; University of Catania
RP De Lorenzo, A (corresponding author), Univ Roma Tor Vergata, Dept Neurosci, Div Human Nutr, Rome, Italy.
EM delorenzo@uniroma2.it
RI Acquaviva, Rosaria/A-6750-2018; Orlandi, Carmine/JUV-6172-2023; Galvano,
   Fabio/JSL-7451-2023; Di Renzo, Laura/ACB-2003-2022; Galvano,
   Fabio/F-8122-2010
OI Di Giacomo, Claudia/0000-0002-2665-0007; Acquaviva,
   Rosaria/0000-0002-3139-1177; De Lorenzo, Antonino/0000-0001-6524-4493;
   Galvano, Fabio/0000-0003-0644-0755; di renzo, laura/0000-0001-8875-6723
FU Ministero Politiche Agricole e Forestali, Italy (PACB) [D.M. 91567 Dic
   29]
FX This study was supported by grants from Ministero Politiche Agricole e
   Forestali, Italy (PACB, D.M. 91567 Dic 29, 2004/2008). The authors'
   responsibilities were as follows: F. G. and L. D. R. designed the study
   and wrote the manuscript; C.O., A. B., C. D. G., L. L. F., R. A.
   collected the data and supervised its collection; A. D. L. analyzed and
   interpreted the data.
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NR 39
TC 92
Z9 100
U1 0
U2 11
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1930-7381
EI 1930-739X
J9 OBESITY
JI Obesity
PD NOV
PY 2010
VL 18
IS 11
BP 2125
EP 2130
DI 10.1038/oby.2010.50
PG 6
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 671GE
UT WOS:000283487700012
PM 20339360
DA 2025-06-11
ER

PT J
AU Issa, CTMI
   Silva, AS
   Toscano, LT
   Medeiros, MS
   Persuhn, DC
   Diniz, AD
   Costa, MJD
   Gonçalves, MDR
AF Mahd Ibrahim Issa, Chahira Taha
   Silva, Alexandre Sergio
   Toscano, Luciana Tavares
   Medeiros, Marcia Silva
   Persuhn, Darlene Camati
   Diniz, Alcides da Silva
   de Carvalho Costa, Maria Jose
   Rodrigues Goncalves, Maria da Conceicao
TI Relationship between cardiometabolic profile, vitamin D status and Bsml
   polymorphism of the VDR gene in non-institutionalized elderly subjects
   Cardiometabolic profile, vitamin D status and Bsml polymorphism of the
   VDR gene in non-institutionalized elderly subjects
SO EXPERIMENTAL GERONTOLOGY
LA English
DT Article
DE Elderly; Vitamin D; Oxidative stress; Hyperglycemia; Polymorphism
ID D-RECEPTOR GENE; 25-HYDROXYVITAMIN D LEVELS; OXIDATIVE STRESS; D
   DEFICIENCY; RISK-FACTORS; CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; D
   SUPPLEMENTATION; FASTING GLUCOSE; INFLAMMATION
AB This study aimed to evaluate the relationship between the cardiometabolic profile, vitamin D status and BsmI polymorphism of the VDR gene in non-institutionalized elderly subjects. A cross-sectional study was conducted with a random and representative sample of 142 elderly subjects selected by cluster and recruited from a municipal assistance program. Clinical, nutritional, biochemical and inflammatory profiles, oxidative stress and genotyping for the BsmI polymorphism were evaluated. Participants had mean age of 69.9 (7.0) years, BMI of 28.3 (4.4) kg/m(2) and 80.3% were women. The prevalence of a 25-hydroxyvitamin D [25(OH) D] status <75 nmol/L was 40.8%. A vitamin D level < 75 nmol/L was found to be associated with gender and fish consumption. The INSUF/DEF group [25(OH) D < 75 nmol/L] showed higher fasting blood glucose MDA values when compared to the SUF group [25(OH) D >= 75 nmol/L]; this relationship was maintained only for women in the analysis by sex. The BsmI polymorphism showed allelic frequencies in the SUF group of B 49% and b 51% and in the INSUF/DEF group B 38% and b 62%. The frequency of bb homozygosity was significantly associated with lower serum total cholesterol and LDL cholesterol concentrations compared to Bb, both in the general population and in the SUF group. Among individuals with bb, the INSUF/DEF group showed higher levels of triglycerides and VLDL cholesterol. Blood glucose levels and oxidative stress were increased in elderly subjects with 25(OH) D < 75 nmol/L. The presence of the bb genotype with adequate vitamin D status resulted in lower total and LDL cholesterol, but the benefit was lost when vitamin D insufficiency or deficiency was present. (C) 2016 Elsevier Inc. All rights reserved.
C1 [Mahd Ibrahim Issa, Chahira Taha; Toscano, Luciana Tavares] Univ Fed Paraiba, Ctr Ciencias Saude, Posgrad Ciencias Nutr, BR-58059900 Joao Pessoa, PB, Brazil.
   [Silva, Alexandre Sergio; de Carvalho Costa, Maria Jose; Rodrigues Goncalves, Maria da Conceicao] Univ Fed Paraiba, Ctr Ciencias Saude, Dept Nutr, Programa Posgrad Ciencias Nutr, BR-58059900 Joao Pessoa, PB, Brazil.
   [Persuhn, Darlene Camati] Univ Fed Paraiba, Dept Biol Mol, Ctr Ciencias Exatas & Nat, BR-58059900 Joao Pessoa, PB, Brazil.
   [Diniz, Alcides da Silva] Univ Fed Pernambuco, Ctr Ciencias Saude, Dept Nutr, Campus 1, BR-50670901 Recife, PE, Brazil.
   [Medeiros, Marcia Silva] Univ Fed Paraiba, Ctr Ciencias Saude, Grad Ciencias Nutr, BR-58059900 Joao Pessoa, PB, Brazil.
   [Mahd Ibrahim Issa, Chahira Taha] Univ Fed Paraiba, Programa Posgrad Ciencias Nutr, Campus 1, BR-58059900 Joao Pessoa, Paraiba, Brazil.
C3 Universidade Federal da Paraiba; Universidade Federal da Paraiba;
   Universidade Federal da Paraiba; Universidade Federal de Pernambuco;
   Universidade Federal da Paraiba; Universidade Federal da Paraiba
RP Issa, CTMI (corresponding author), Rua Francisca Bento de Farias Apto 301, BR-58035245 Joao Pessoa, Paraiba, Brazil.; Issa, CTMI (corresponding author), Univ Fed Paraiba, Programa Posgrad Ciencias Nutr, Campus 1, BR-58059900 Joao Pessoa, Paraiba, Brazil.
EM chahiraissa@hotmail.com
RI darlene persuhn, DC/U-4682-2018; Diniz, Alcides/LVS-6640-2024; Silva,
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NR 71
TC 12
Z9 12
U1 0
U2 11
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0531-5565
EI 1873-6815
J9 EXP GERONTOL
JI Exp. Gerontol.
PD AUG
PY 2016
VL 81
BP 56
EP 64
DI 10.1016/j.exger.2016.04.020
PG 9
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA DR0JY
UT WOS:000379595000009
PM 27125758
DA 2025-06-11
ER

PT J
AU Ceriello, A
   Esposito, K
   La Sala, L
   Pujadas, G
   De Nigris, V
   Testa, R
   Bucciarelli, L
   Rondinelli, M
   Genovese, S
AF Ceriello, Antonio
   Esposito, Katherine
   La Sala, Lucia
   Pujadas, Gemma
   De Nigris, Valeria
   Testa, Roberto
   Bucciarelli, Loredana
   Rondinelli, Maurizio
   Genovese, Stefano
TI The protective effect of the Mediterranean diet on endothelial
   resistance to GLP-1 in type 2 diabetes: a preliminary report
SO CARDIOVASCULAR DIABETOLOGY
LA English
DT Article
DE Diabetes mellitus; Acute hyperglycemia; GLP-1; Oxidative stress;
   Mediterranean diet
ID GLUCAGON-LIKE PEPTIDE-1; INCRETIN-BASED THERAPIES; VIRGIN OLIVE OIL;
   OXIDATIVE STRESS; ACUTE HYPERGLYCEMIA; VITAMIN-C;
   CARDIOVASCULAR-DISEASE; ANTIOXIDANT CAPACITY; METABOLIC SYNDROME;
   INSULIN-SECRETION
AB Background: In type 2 diabetes, acute hyperglycemia worsens endothelial function and inflammation, while resistance to GLP-1 action occurs. All these phenomena seem to be related to the generation of oxidative stress. A Mediterranean diet, supplemented with olive oil, increases plasma antioxidant capacity, suggesting that its implementation can have a favorable effect on the aforementioned phenomena. In the present study, we test the hypothesis that a Mediterranean diet using olive oil can counteract the effects of acute hyperglycemia and can improve the resistance of the endothelium to GLP-1 action.
   Methods: Two groups of type 2 diabetic patients, each consisting of twelve subjects, participated in a randomized trial for three months, following a Mediterranean diet using olive oil or a control low-fat diet. Plasma antioxidant capacity, endothelial function, nitrotyrosine, 8-iso-PGF2a, IL-6 and ICAM-1 levels were evaluated at baseline and at the end of the study. The effect of GLP-1 during a hyperglycemic clamp, was also studied at baseline and at the end of the study.
   Results: Compared to the control diet, the Mediterranean diet increased plasma antioxidant capacity and improved basal endothelial function, nitrotyrosine, 8-iso-PGF2a, IL-6 and ICAM-1 levels. The Mediterranean diet also reduced the negative effects of acute hyperglycemia, induced by a hyperglycemic clamp, on endothelial function, nitrotyrosine, 8-iso-PGF2a, IL-6 and ICAM-1 levels. Furthermore, the Mediterranean diet improved the protective action of GLP-1 on endothelial function, nitrotyrosine, 8-iso-PGF2a, IL-6 and ICAM-1 levels, also increasing GLP-1-induced insulin secretion.
   Conclusions: These data suggest that the Mediterranean diet, using olive oil, prevents the acute hyperglycemia effect on endothelial function, inflammation and oxidative stress, and improves the action of GLP-1, which may have a favorable effect on the management of type 2 diabetes, particularly for the prevention of cardiovascular disease.
C1 [Ceriello, Antonio; La Sala, Lucia; Pujadas, Gemma; De Nigris, Valeria] Hosp Clin Barcelona, Inst Invest Biomed August Pi i Sunyer, Barcelona 08036, Spain.
   [Ceriello, Antonio; La Sala, Lucia; Pujadas, Gemma; De Nigris, Valeria] Hosp Clin Barcelona, Ctr Invest Biomed Red Diabet & Enfermedades Metab, Barcelona 08036, Spain.
   [Esposito, Katherine] 2 Univ Naples SUN, Ctr Excellence Cardiovasc Dis, Div Metab Dis, Naples, Italy.
   [Testa, Roberto] INRCA IRCCS Natl Inst, Expt Models Clin Pathol, Ancona, Italy.
   [Bucciarelli, Loredana; Rondinelli, Maurizio; Genovese, Stefano] IRCCS, Dept Cardiovasc & Metab Dis, Grp Multimed, Sesto San Giovanni, MI, Italy.
C3 University of Barcelona; Hospital Clinic de Barcelona; IDIBAPS; CIBER -
   Centro de Investigacion Biomedica en Red; CIBERDEM; University of
   Barcelona; Hospital Clinic de Barcelona; IRCCS INRCA
RP Ceriello, A (corresponding author), Hosp Clin Barcelona, Inst Invest Biomed August Pi i Sunyer, C Rossello 149-153, Barcelona 08036, Spain.
EM aceriell@clinic.ub.es
RI bucciarelli, loredana/JMB-6796-2023; Testa, Roberto/ABH-7467-2020;
   Esposito, Katherine/AHE-2564-2022; Ceriello, Antonio/J-9575-2016; La
   Sala, Lucia/A-4467-2019; La Sala, Lucia/Q-9969-2016; Genovese,
   Stefano/F-9706-2017
OI Ceriello, Antonio/0000-0001-8122-3203; Pujadas,
   Gemma/0000-0002-3871-5883; Bucciarelli, Loredana/0000-0001-9110-6529; La
   Sala, Lucia/0000-0002-7580-1377; DE NIGRIS, VALERIA/0000-0002-7556-4906;
   Testa, Roberto/0000-0001-8308-7663; Genovese,
   Stefano/0000-0002-6085-437X
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NR 37
TC 58
Z9 64
U1 0
U2 12
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1475-2840
J9 CARDIOVASC DIABETOL
JI Cardiovasc. Diabetol.
PD NOV 19
PY 2014
VL 13
AR 140
DI 10.1186/s12933-014-0140-9
PG 9
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism
GA AW1PK
UT WOS:000346061600001
PM 25407792
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Asemi, Z
   Samimi, M
   Tabassi, Z
   Shakeri, H
   Sabihi, SS
   Esmaillzadeh, A
AF Asemi, Zatollah
   Samimi, Mansooreh
   Tabassi, Zohreh
   Shakeri, Hossein
   Sabihi, Sima-Sadat
   Esmaillzadeh, Ahmad
TI Effects of DASH diet on lipid profiles and biomarkers of oxidative
   stress in overweight and obese women with polycystic ovary syndrome: A
   randomized clinical trial
SO NUTRITION
LA English
DT Article
DE DASH; Polycystic-ovary syndrome; Lipids; Oxidative stress; Women
ID HORMONE BINDING GLOBULIN; BLOOD-PRESSURE; METABOLIC SYNDROME;
   INSULIN-RESISTANCE; DIAGNOSTIC-CRITERIA; GLUCOSE-TOLERANCE; MAGNESIUM
   INTAKE; SODIUM-INTAKE; HIGH-PROTEIN; EATING PLAN
AB Objective: The aim of this study was to assess the effects of the Dietary Approaches to Stop Hypertension (DASH) diet on lipid profiles and biomarkers of oxidative stress in overweight and obese women with polycystic ovary syndrome (PCOS).
   Methods: This randomized controlled clinical trial was conducted with 48 women diagnosed with PCOS. The women were randomly assigned to consume either the control (n = 24) or DASH diet (n = 24) for 8 wk. Both diets were designed to be calorie-restricted. Both diets consisted of 52% carbohydrates, 18% proteins, and 30% total fats. The DASH diet was designed to be rich in fruits, vegetables, whole grains, and low-fat dairy products and to be low in saturated fats, cholesterol, and refined grains. Fasting blood samples were taken at baseline and after 8-wk intervention to measure lipid profiles and biomarkers of oxidative stress including plasma total antioxidant capacity (TAC) and total glutathione (GSH).
   Results: Adherence to the DASH diet, compared with the control diet, resulted in a significant decrease in weight (-4.4 versus -1.5 kg; P < 0.001) and body mass index (-1.7 versus -0.6 kg/m(2); P < 0.001), decreased serum triglycerides (-10.0 versus +19.2 mg/dL; P interaction = 0.005) and very-low-density lipoprotein cholesterol levels (-2.0 versus +3.9 mg/dL; P interaction = 0.005). Increased concentrations of TAC (+98.6 versus -174.8 mmol/L; P interaction <0.001) and GSH (+66.4 versus -155.6 mu mol/L; P interaction = 0.005) also were found in the DASH group compared with the control group.
   Conclusion: Consumption of DASH diet for 8 wk led to a significant reduction in serum insulin, triglycerides and very-low-density lipoprotein cholesterol and a significant increase in TAC and GSH levels. (C) 2014 Elsevier Inc. All rights reserved.
C1 [Asemi, Zatollah; Shakeri, Hossein; Sabihi, Sima-Sadat] Kashan Univ Med Sci, Res Ctr Biochem & Nutr Metab Dis, Kashan, Iran.
   [Samimi, Mansooreh; Tabassi, Zohreh] Kashan Univ Med Sci, Sch Med, Dept Gynecol & Obstet, Kashan, Iran.
   [Esmaillzadeh, Ahmad] Isfahan Univ Med Sci, Food Secur Res Ctr, Esfahan, Iran.
   [Esmaillzadeh, Ahmad] Isfahan Univ Med Sci, Sch Nutr & Food Sci, Dept Community Nutr, Esfahan, Iran.
C3 Isfahan University of Medical Sciences; Isfahan University of Medical
   Sciences
RP Esmaillzadeh, A (corresponding author), Isfahan Univ Med Sci, Food Secur Res Ctr, Esfahan, Iran.
EM Esmaillzadeh@hlth.mui.ac.ir
RI asemi, zatollah/J-2677-2018; Tabassi, Zohreh/V-3979-2017; Samimi,
   Mansoreh/V-3813-2017; Esmaillzadeh, Ahmad/N-5704-2014; Asemi,
   Zatollah/G-7393-2017
OI Tabassi, Zohreh/0000-0002-5860-892X; Samimi,
   Mansoreh/0000-0002-5809-3612; Esmaillzadeh, Ahmad/0000-0002-8735-6047;
   Asemi, Zatollah/0000-0001-5265-4792
FU KUMS, Kashan, Iran [9213]
FX The present study was supported by a grant (no. 9213) from the
   vice-chancellor for research, KUMS, Kashan, Iran. ZA conducted the
   study, carried out the statistical analyses, drafted the manuscript, and
   contributed to the interpretation of the findings. MS, ZT, HS, and S-SS
   contributed to the data collection and assisted in drafting the
   manuscript. AE contributed to the conception and design, advised on
   statistical analyses, and assisted in interpretation of the findings.
   None of the authors had any personal or financial conflict of interest.
   All authors approved the final version for submission.
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NR 59
TC 97
Z9 102
U1 2
U2 51
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0899-9007
EI 1873-1244
J9 NUTRITION
JI Nutrition
PD NOV-DEC
PY 2014
VL 30
IS 11-12
BP 1287
EP 1293
DI 10.1016/j.nut.2014.03.008
PG 7
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA AQ7AE
UT WOS:000342964200007
PM 25194966
DA 2025-06-11
ER

PT J
AU Powell-Wiley, TM
   Ayers, C
   Agyemang, P
   Leonard, T
   Berrigan, D
   Ballard-Barbash, R
   Lian, M
   Das, SR
   Hoehner, CM
AF Powell-Wiley, Tiffany M.
   Ayers, Colby
   Agyemang, Priscilla
   Leonard, Tammy
   Berrigan, David
   Ballard-Barbash, Rachel
   Lian, Min
   Das, Sandeep R.
   Hoehner, Christine M.
TI Neighborhood-level socioeconomic deprivation predicts weight gain in a
   multi-ethnic population: Longitudinal data from the Dallas Heart Study
SO PREVENTIVE MEDICINE
LA English
DT Article
DE Neighborhood environment; Socioeconomic status; Socioeconomic
   deprivation; Obesity
ID BODY-MASS INDEX; CARDIOMETABOLIC RISK-FACTORS; PSYCHOSOCIAL STRESS;
   PHYSICAL-ACTIVITY; OBESITY; BMI; ASSOCIATIONS; ENVIRONMENT; MULTILEVEL;
   HEALTH
AB Objective. The aim of this study is to examine a relationship between neighborhood-level socioeconomic deprivation and weight change in a multi-ethnic cohort from Dallas County, Texas and whether behavioral/psychosocial factors attenuate the relationship.
   Methods. Non-movers (those in the same neighborhood throughout the study period) aged 18-65 (N = 939) in Dallas Heart Study (DHS) underwent weight measurements between 2000 and 2009 (median 7-year follow-up). Geocoded home addresses defined block groups; a neighborhood deprivation index (NDI) was created (higher NDI = greater deprivation). Multi-level modeling determined weight change relative to NDI. Model fit improvement was examined with adding physical activity and neighborhood environment perceptions (higher score = more unfavorable perceptions) as covariates. A significant interaction between residence length and NDI was found (p-interaction = 0.04); results were stratified by median residence length (11 years).
   Results. Adjusting for age, sex, race/ethnicity, smoking, and education/income, those who lived in neighborhood > 11 years gained 1.0 kg per one-unit increment of NDI (p = 0.03), or 6 kg for those in highest NDI tertile compared with those in the lowest tertile. Physical activity improved model fit; NDI remained associated with weight gain after adjustment for physical activity and neighborhood environment perceptions. There was no significant relationship between NDI and weight change for those in their neighborhood <= 11 years.
   Conclusions. Living in more socioeconomically deprived neighborhoods over a longer time period was associated with weight gain in DHS. Published by Elsevier Inc.
C1 [Powell-Wiley, Tiffany M.; Agyemang, Priscilla] NHLBI, Cardiovasc & Pulm Branch, NIH, Bethesda, MD 20892 USA.
   [Ayers, Colby; Das, Sandeep R.] Univ Texas Dallas, SW Med Ctr, Dept Med, Div Cardiol, Dallas, TX 75235 USA.
   [Leonard, Tammy] Univ Texas Dallas, Dept Econ, Richardson, TX 75080 USA.
   [Powell-Wiley, Tiffany M.; Berrigan, David; Ballard-Barbash, Rachel] NCI, Appl Res Program, Div Canc Control & Populat Sci, Rockville, MD 20850 USA.
   [Lian, Min; Hoehner, Christine M.] Washington Univ, St Louis, MO 63130 USA.
C3 National Institutes of Health (NIH) - USA; NIH National Heart Lung &
   Blood Institute (NHLBI); University of Texas System; University of Texas
   Dallas; University of Texas Southwestern Medical Center Dallas;
   University of Texas System; University of Texas Dallas; National
   Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI);
   NIH Division of Cancer Control & Population Sciences; Washington
   University (WUSTL)
RP Powell-Wiley, TM (corresponding author), NCI, Cardiovasc & Pulm Branch, Div Intramural Res,NHLBI,Appl Res Program, Div Canc Control & Populat Studies,NIH, Bldg 10,Room 5E3340, Bethesda, MD 20892 USA.
EM tiffany.powell@nih.gov; colby.ayers@utsouthwestern.edu;
   pagyeman169@gmail.com; Leonard@utdallas.edu; berrigad@mail.nih.gov;
   barbashr@mail.nih.gov; mlian@dom.wustl.edu;
   Sandeep.das@utsouthwestem.edu; christyhoehner@gmail.com
RI PowellWiley, Tiffany/MCY-2981-2025; Leonard, Tammy/AFH-1258-2022;
   Berrigan, David/AAF-1576-2020
OI Berrigan, David/0000-0002-5333-179X; Powell-Wiley, Tiffany
   M./0000-0001-9488-4131; Leonard, Tammy/0000-0002-8621-9358
FU Division of Intramural Research of NHLBI at NIH [ZIA HL006148-02,
   HHSN268201300173P]
FX Funding for Dr. Powell-Wiley and Ms. Agyemang is provided by the
   Division of Intramural Research of NHLBI at NIH (ZIA HL006148-02).
   Funding for Mr. Ayers is provided through a professional services
   contract (contract # HHSN268201300173P) through the Division of
   Intramural Research of NHLBI at NIH. The funding source had no role in
   the study design, collection, analysis, and interpretation of data, in
   writing of the report, or in the decision to submit the article for
   publication.
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NR 45
TC 70
Z9 82
U1 0
U2 8
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0091-7435
EI 1096-0260
J9 PREV MED
JI Prev. Med.
PD SEP
PY 2014
VL 66
BP 22
EP 27
DI 10.1016/j.ypmed.2014.05.011
PG 6
WC Public, Environmental & Occupational Health; Medicine, General &
   Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; General & Internal Medicine
GA AM9RB
UT WOS:000340217600005
PM 24875231
OA Green Accepted, Green Submitted
DA 2025-06-11
ER

PT J
AU Zhang, MQ
   Guo, CC
   Li, ZL
   Cai, XL
   Wen, X
   Lv, F
   Lin, C
   Ji, LN
AF Zhang, Mengqing
   Guo, Chengcheng
   Li, Zonglin
   Cai, Xiaoling
   Wen, Xin
   Lv, Fang
   Lin, Chu
   Ji, Linong
TI Mulberry Twig Alkaloids Improved the Progression of Metabolic-Associated
   Fatty Liver Disease in High-Fat Diet-Induced Obese Mice by Regulating
   the PGC1α/PPARα and KEAP1/NRF2 Pathways
SO PHARMACEUTICALS
LA English
DT Article
DE MAFLD; mulberry twig alkaloids; PGC1 alpha; NRF2; lipid metabolism;
   anti-oxidative stress
ID PROTECTS
AB Background/Objectives: Metabolic-associated fatty liver disease (MAFLD) is one of the most common liver disorders associated with obesity and metabolic syndrome, and poses a significant global health burden with limited effective treatments. The aim of this study was to assess the protective effects of mulberry twig alkaloids (SZ-A) on MAFLD and to further investigate the underlying mechanisms including the specific targets or pathways. Methods: Diet-induced obesity (DIO) and normal mouse models were established by feeding C57Bl/6J mice with a high-fat diet (HFD) or common diet for 12 weeks. SZ-A, dapagliflozin, and placebo were administered to corresponding mouse groups for 8 weeks. Data of fasting blood glucose, glucose tolerance, insulin tolerance, and the body weight of mice were collected at the baseline and termination of the experiment. Serum liver enzymes and lipids were measured by ELISA. Western blotting, qPCR, and pathological section staining were implemented to evaluate the degrees of liver steatosis, fibrosis, and oxidative stress in mice. Results: In DIO mouse models, high-dose SZ-A (800 mg/kg/d) treatment significantly inhibited HFD-induced weight gain, improved insulin tolerance, and reduced serum alanine aminotransferase, total cholesterol, and triglyceride levels compared with placebo. In DIO mice, SZ-A could alleviate the pathological changes of hepatic steatosis and fibrosis compared with placebo. Lipid catabolism and antioxidant stress-related proteins were significantly increased in the livers of the high-dose SZ-A group (p < 0.05). Inhibition of PGC1 alpha could inhibit the function of SZ-A to enhance lipid metabolism in hepatocytes. PGC1 alpha might interact with NRF2 to exert MAFLD-remedying effects. Conclusions: By regulating the expression of PGC1 alpha and its interacting KEAP1/NRF2 pathway in mouse liver cells, SZ-A played important roles in regulating lipid metabolism, inhibiting oxidative stress, and postponing liver fibrosis in mice with MAFLD.
C1 [Zhang, Mengqing; Guo, Chengcheng; Li, Zonglin; Cai, Xiaoling; Wen, Xin; Lv, Fang; Lin, Chu; Ji, Linong] Peking Univ, Peoples Hosp, Dept Endocrinol & Metab, Beijing 100044, Peoples R China.
C3 Peking University
RP Cai, XL; Ji, LN (corresponding author), Peking Univ, Peoples Hosp, Dept Endocrinol & Metab, Beijing 100044, Peoples R China.
EM dr_junel@sina.com; jiln@bjmu.edu.cn
RI Linong, Ji/AAB-6543-2020; Cai, Xiaoling/AFR-4880-2022
FU Chinese Journal of Diabetes;  [2119000446]
FX This work was supported by the Chinese Journal of Diabetes (No.
   2119000446). The funding agencies had no roles in the study design, data
   collection or analysis, decision to publish, or preparation of the
   manuscript.
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Z9 3
U1 4
U2 6
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1424-8247
J9 PHARMACEUTICALS-BASE
JI Pharmaceuticals
PD OCT
PY 2024
VL 17
IS 10
AR 1287
DI 10.3390/ph17101287
PG 16
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA K4P2J
UT WOS:001343703800001
PM 39458927
OA gold
DA 2025-06-11
ER

PT J
AU Gianturco, V
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AF Gianturco, V.
   Bellomo, A.
   D'Ottavio, E.
   Formosa, V.
   Iori, A.
   Mancinella, M.
   Troisi, G.
   Marigliano, V.
TI IMPACT OF THERAPY WITH α-LIPOIC ACID (ALA) ON THE OXIDATIVE STRESS IN
   THE CONTROLLED NIDDM: A POSSIBLE PREVENTIVE WAY AGAINST THE ORGAN
   DYSFUNCTION?
SO ARCHIVES OF GERONTOLOGY AND GERIATRICS
LA English
DT Article
DE alpha-lipoic acid; NIDDM-complications; total cholesterol, high-density
   lipoprotein-cholesterol; low-density lipoprotein-cholesterol, d-ROMs
   test; C-reactive protein, oxidative stress
ID SYMPTOMATIC DIABETIC POLYNEUROPATHY; NEUROPATHY
AB There is a growing evidence that excess generation of highly reactive free radicals, largely due to hyperglycemia, causes oxidative stress, which further exacerbates the development and progression of diabetes and its complications. The purpose of this study was to evaluate the impact of ALA on lipid profile, oxidative pattern and inflammation in patients with controlled non-insulin dependent diabetes mellitus (NIDDM). ALA, 400 mg/day was investigated in NIDDM patients over a period of 4 weeks using a randomized, placebo-(PLA)-controlled study with two parallel groups. The marker of oxidative stress was the concentration of reactive oxygen metabolites, evaluated using a commercially available test, called d-ROMs test, and the biological antioxidant potential (BAP); besides, the lipid profile (total cholesterol = TC, high-density lipoprotein-cholesterol = HDL-C; low-density lipoprotein-cholesterol = LDL-C, and triglycerides = TG) and the C-reactive protein (CRP), marker of inflammation were measured at the beginning and at the end of the treatment. A total of 14 patients were randomly assigned to the two groups. ALA was safe and well tolerated in the only oral daily administration. The d-ROMs test (p = 0.03) and HDL-C (p = 0.04) showed a significant difference between the two groups. BAP (p = 0.06) tended to be higher in the treated patients, while LDL-C (p = 0.07) presented a moderate decline. There were no significant differences in TC (p = 0.65), TG (p = 0.78) and CRP (p = 0.96) between the ALA and PLA groups. ALA therapy appears to reduce significantly d-ROMs and to improve HDL-C value, especially in men with metabolic syndrome treated with oral hypoglycemic drugs. These findings will be useful in patient selection in future clinical trials with ALA in long term studies.
C1 [Gianturco, V.; Bellomo, A.; D'Ottavio, E.; Formosa, V.; Iori, A.; Mancinella, M.; Troisi, G.; Marigliano, V.] Sapienza Univ Roma, Dipartimento Sci Invecchiamento, Umberto Policlin Roma 1, I-00161 Rome, Italy.
C3 Sapienza University Rome; University Hospital Sapienza Rome
RP Marigliano, V (corresponding author), Sapienza Univ Roma, Dipartimento Sci Invecchiamento, Umberto Policlin Roma 1, Viale Policlin 155, I-00161 Rome, Italy.
EM vincenzo.marigliano@uniroma1.it
OI TROISI, Giovanni/0000-0002-0647-5504
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NR 8
TC 46
Z9 50
U1 0
U2 5
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0167-4943
EI 1872-6976
J9 ARCH GERONTOL GERIAT
JI Arch. Gerontol. Geriatr.
PY 2009
VL 49
SU 1
BP 129
EP 133
DI 10.1016/j.archger.2009.09.022
PG 5
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA 525AK
UT WOS:000272185300018
PM 19836626
DA 2025-06-11
ER

PT J
AU Gallart-Palau, X
   Muntané, G
   Martorell, L
   Amigó, N
   Correig, X
   Ribalta, J
   Sánchez-Gistau, V
   Labad, J
   Vilella, E
AF Gallart-Palau, Xavier
   Muntane, Gerard
   Martorell, Lourdes
   Amigo, Nuria
   Correig, Xavier
   Ribalta, Josep
   Sanchez-Gistau, Vanessa
   Labad, Javier
   Vilella, Elisabet
TI Gradual Increase in Inflammation-Linked Glycoproteins and a
   Proatherogenic Lipoprotein Profile in the Early Stages of Psychosis as
   Characterized by <SUP>1</SUP>H NMR Blood Analysis
SO JOURNAL OF PROTEOME RESEARCH
LA English
DT Article
DE ARMS; blood markers; early psychosis; first episode of psychosis;
   glycoprotein; GlycA; GlycB; HDL; H-1 NMR; lipoprotein; remnant
   lipoprotein
ID NUCLEAR-MAGNETIC-RESONANCE; RISK MENTAL STATES; METABOLIC SYNDROME;
   SCHIZOPHRENIA; DEPRESSION; BIOMARKERS; CONSENSUS; GLYCA; ABNORMALITIES;
   ASSOCIATIONS
AB Minimally invasive prognostic markersof inflammation and dyslipidemiain individuals with a risk of psychosis, also called "at-riskmental state" (ARMS), or in the first episode of psychosis(FEP) are of utmost clinical importance to prevent cardiovasculardisorders. We analyzed the plasma concentration of inflammation-linkedglycoproteins (Glycs) and lipoprotein subclasses by proton nuclearmagnetic resonance (H-1 NMR) in a single acquisition. Studyparticipants were healthy controls (HCs, N = 67) and patients withARMS (N = 58), FEP (N = 110), orearly psychosis diagnosis with & GE;2 episodes (critical period(CP), N = 53). Clinical biomarkers such as high-sensitivityC-reactive protein, interleukin 6, fibrinogen, insulin, and lipoproteinswere also measured. Although all participants had normal lipoproteinprofiles and no inflammation according to conventional biomarkers,a gradual increase in the Glyc H-1 NMR levels was observedfrom HCs to CP patients; this increase was statistically significantfor GlycA (CP vs HC). In parallel, a progressive and significant proatherogenic H-1 NMR lipoprotein profile was also identified across stagesof psychosis (ARMS and CP vs HC). These findings highlight the potentialof using H-1 NMR Glyc and lipoprotein profiling to identifyblood changes in individuals with ARMS or FEP and pave the way forapplications using this technology to monitor metabolic and cardiovascularrisks in clinical psychiatry.
C1 [Gallart-Palau, Xavier; Muntane, Gerard; Martorell, Lourdes; Amigo, Nuria; Correig, Xavier; Ribalta, Josep; Sanchez-Gistau, Vanessa; Vilella, Elisabet] Inst Invest Sanitaria Pere Virgili IISPV CERCA, Reus 43204, Spain.
   [Gallart-Palau, Xavier; Muntane, Gerard; Martorell, Lourdes; Sanchez-Gistau, Vanessa; Vilella, Elisabet] Hosp Univ Inst Pere Mata, Reus 43206, Spain.
   [Gallart-Palau, Xavier; Muntane, Gerard; Martorell, Lourdes; Sanchez-Gistau, Vanessa; Labad, Javier; Vilella, Elisabet] Inst Salud Carlos III, Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid 28029, Spain.
   [Gallart-Palau, Xavier] Proteored Inst Salud Carlos III ISCIII, Madrid 28029, Spain.
   [Gallart-Palau, Xavier; Muntane, Gerard] Univ Lleida UdL, Univ Hosp Arnau de Vilanova HUAV, Biomed Res Inst Lleida Dr Pifarre Fdn IRBLLEIDA, Psychol Dept, Lleida 25198, Spain.
   [Muntane, Gerard; Martorell, Lourdes; Amigo, Nuria; Correig, Xavier; Ribalta, Josep; Sanchez-Gistau, Vanessa; Vilella, Elisabet] Univ Rovira & Virgili, Reus 43201, Spain.
   [Muntane, Gerard] Univ Pompeu Fabra, Inst Evolutionary Biol UPF CSIC, Dept Expt & Hlth Sci, Barcelona 08005, Spain.
   [Amigo, Nuria] Biosfer Teslab, Reus 43201, Spain.
   [Amigo, Nuria; Correig, Xavier; Ribalta, Josep] Inst Salud Carlos III, Ctr Invest Biomed Red Diabet & Enfermedades Metabo, Madrid 28029, Spain.
   [Labad, Javier] Consorci Sanitari Maresme, Dept Mental Hlth, Mataro 08304, Spain.
   [Labad, Javier] Inst Invest & Innovacio Parc Tauli I3PT CERCA, Sabadell 08208, Spain.
   Ctr Biomed Res Unit I3PT INc UAB, Bellaterra 08193, Spain.
C3 Instituto de Salud Carlos III; CIBER - Centro de Investigacion Biomedica
   en Red; CIBERSAM; Universitat de Lleida; Universitat Rovira i Virgili;
   Consejo Superior de Investigaciones Cientificas (CSIC); CSIC-UPF -
   Institut de Biologia Evolutiva (IBE); Pompeu Fabra University; Instituto
   de Salud Carlos III
RP Vilella, E (corresponding author), Inst Invest Sanitaria Pere Virgili IISPV CERCA, Reus 43204, Spain.; Vilella, E (corresponding author), Hosp Univ Inst Pere Mata, Reus 43206, Spain.; Vilella, E (corresponding author), Inst Salud Carlos III, Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid 28029, Spain.; Vilella, E (corresponding author), Univ Rovira & Virgili, Reus 43201, Spain.
EM vilellae@premata.com
RI Gallart-Palau, Xavier/L-6566-2016; sanchez, vanessa/KBC-3471-2024;
   Vilella, Elisabet/HII-9781-2022; Muntane, Gerard/V-4477-2019
OI Martorell, Lourdes/0000-0003-4999-2197
FU Fundacio~La Marato~de TV3 [092230, 092231]; Instituto de Salud Carlos
   III [PI10/01607, PI21/01294]; European Union; Agencia Catalana de Gestio
   d'Ajuts per Universitats i Recerca (AGAUR) [2017SGR444]
FX We are grateful to the young patients and HCs who participated in this
   study. We also thank the technicians from the IISPV Biobank in Reus
   (http://www.iispv.cat) for sample management. Funding for this study was
   provided by Fundacio & nbsp;La Marato & nbsp;de TV3 (grant numbers
   092230, 092231) and the Instituto de Salud Carlos III (grant numbers
   PI10/01607 to J.L. and PI21/01294 to J.R. and Sara Borrell contract to
   X.G.) and co-funded by the European Union and the Agencia Catalana de
   Gestio & nbsp;d'Ajuts per Universitats i Recerca (AGAUR) (grant number
   2017SGR444 to E.V.).
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NR 67
TC 2
Z9 2
U1 1
U2 6
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1535-3893
EI 1535-3907
J9 J PROTEOME RES
JI J. Proteome Res.
PD JUN 24
PY 2023
VL 22
IS 7
BP 2271
EP 2280
DI 10.1021/acs.jproteome.2c00847
EA JUN 2023
PG 10
WC Biochemical Research Methods
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA M6TH1
UT WOS:001018139700001
PM 37354121
DA 2025-06-11
ER

PT J
AU Poveda, I
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AF Poveda, Ines
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   Martorell, Antonio
   Javier Garcia-Martinez, Francisco
   Manuel Segura, Juan
   Hispan, Patricia
   Sanchez-Paya, Jose
   Jose Alvarez, Pedro
   Gonzalez, Iris
   Carlos Pascual, Jose
TI Serum Zinc Levels in Hidradenitis Suppurativa: A Case-Control Study
SO AMERICAN JOURNAL OF CLINICAL DERMATOLOGY
LA English
DT Article
ID METABOLIC SYNDROME; ACNE-VULGARIS; SUPPLEMENTATION; METAANALYSIS;
   PREVALENCE; DISEASE; COMORBIDITIES; DEFICIENCY; DEPRESSION
AB BackgroundSerum zinc levels in patients with hidradenitis suppurativa (HS) have not been previously studied.ObjectiveThe aim was to investigate the association between HS and serum zinc levels.MethodsA multicenter, prospective clinical and analytical case-control study was designed to assess the possible association between HS and serum zinc levels. Consecutive patients with moderate or severe HS (Hurley II or III exclusively) were enrolled. A control population was recruited from primary care clinics. Fasting blood samples were extracted from each patient and serum zinc levels determined. Candidate predictors for low serum zinc levels were determined using logistic regression models.ResultsIn total, 122 patients with HS and 122 control subjects were studied. Of the 122 HS patients, 79 (64.8%) were Hurley II and 43 (35.2%) were Hurley III. Low serum zinc levels (83.3 mu g/dL) were more prevalent in HS (adjusted odds ratio [ORa] 6.7, P<0.001). After logistic regression analysis, low serum zinc levels were associated with Hurley III (ORa 4.4, P<0.001), Dermatology Life Quality Index9 (ORa 3.1, P=0.005), number of affected sites3 (ORa 2.4, P=0.042), genital location (ORa 2.9, P=0.009), and perineal location (ORa 2.5, P=0.025).ConclusionLow serum zinc levels are more prevalent in HS than in a healthy population, an indicator that may also be associated with disease severity.
C1 [Poveda, Ines; Hispan, Patricia; Jose Alvarez, Pedro; Carlos Pascual, Jose] Alicante Univ Gen Hosp, Dept Dermatol, Alicante Inst Hlth & Biomed Res, ISABIAL FISABIO Fdn, Pintor Baeza 11 St, Alicante 03010, Spain.
   [Vilarrasa, Eva] Univ Autonoma Barcelona, Dept Dermatol, Hosp Santa Creu & St Pau, Barcelona, Spain.
   [Martorell, Antonio] Hosp Manises, Dept Dermatol, Valencia, Spain.
   [Javier Garcia-Martinez, Francisco] Clin Univ Navarra, Dept Dermatol, Madrid, Spain.
   [Manuel Segura, Juan] Hosp Costa del Sol, Dept Dermatol, Marbella, Spain.
   [Sanchez-Paya, Jose] Alicante Univ Gen Hosp, Alicante Inst Hlth & Biomed Res, Epidemiol Unit, ISABIAL FISABIO Fdn, Alicante, Spain.
   [Gonzalez, Iris] Hosp Marina Baixa, Dept Dermatol, Alicante, Spain.
C3 General University Hospital of Alicante; Universidad Miguel Hernandez de
   Elche; Universitat d'Alacant; Instituto de Investigacion Sanitaria y
   Biomedica de Alicante (ISABIAL); Hospital of Santa Creu i Sant Pau;
   Autonomous University of Barcelona; University of Navarra; General
   University Hospital of Alicante; Universidad Miguel Hernandez de Elche;
   Universitat d'Alacant; Instituto de Investigacion Sanitaria y Biomedica
   de Alicante (ISABIAL)
RP Poveda, I (corresponding author), Alicante Univ Gen Hosp, Dept Dermatol, Alicante Inst Hlth & Biomed Res, ISABIAL FISABIO Fdn, Pintor Baeza 11 St, Alicante 03010, Spain.
EM inespovedamontoyo@gmail.com
RI Martorell Calatayud, Antonio/JLK-9722-2023; Sánchez-Payá,
   José/N-6851-2017; Garcia Martinez, Francisco Javier/AAC-7213-2020
OI Martorell, Antonio/0000-0003-1378-1590; PASCUAL, JOSE
   C./0000-0001-8279-215X; Garcia Martinez, Francisco
   Javier/0000-0003-0175-8123
CR Alikhan A, 2009, J AM ACAD DERMATOL, V60, P539, DOI 10.1016/j.jaad.2008.11.911
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   Boyle M, 2018, J HEPATOL, V68, P251, DOI 10.1016/j.jhep.2017.11.006
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   Brocard A, 2007, DERMATOLOGY, V214, P325, DOI 10.1159/000100883
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   Gupta M, 2014, DERMAT RES PRACT, V2014, DOI 10.1155/2014/709152
   Hessam S, 2016, J DERMATOL SCI, V84, P197, DOI 10.1016/j.jdermsci.2016.08.010
   Jemec GBE, 2015, J AM ACAD DERMATOL, V73, pS4, DOI 10.1016/j.jaad.2015.07.052
   Kelly G, 2016, DERMATOL CLIN, V34, P51, DOI 10.1016/j.det.2015.08.004
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NR 36
TC 26
Z9 27
U1 0
U2 10
PU ADIS INT LTD
PI NORTHCOTE
PA 5 THE WAREHOUSE WAY, NORTHCOTE 0627, AUCKLAND, NEW ZEALAND
SN 1175-0561
EI 1179-1888
J9 AM J CLIN DERMATOL
JI Am. J. Clin. Dermatol.
PD OCT
PY 2018
VL 19
IS 5
BP 771
EP 777
DI 10.1007/s40257-018-0374-5
PG 7
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA GS8OS
UT WOS:000443972200011
PM 30043129
DA 2025-06-11
ER

PT J
AU Wright, MJ
   Woo, E
   Birath, JB
   Siders, CA
   Kelly, DF
   Wang, C
   Swerdloff, R
   Romero, E
   Kernan, C
   Cantu, RC
   Guskiewicz, K
AF Wright, Mathew J.
   Woo, Ellen
   Birath, J. Brandon
   Siders, Craig A.
   Kelly, Daniel F.
   Wang, Christina
   Swerdloff, Ronald
   Romero, Elizabeth
   Kernan, Claudia
   Cantu, Robert C.
   Guskiewicz, Kevin
TI An index predictive of cognitive outcome in retired professional
   American Football players with a history of sports concussion
SO JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY
LA English
DT Article
DE Traumatic brain injury; Cognitive reserve; Cerebral concussion; Sports;
   Cognition
ID TRAUMATIC BRAIN-INJURY; RECURRENT CONCUSSION; METABOLIC SYNDROME; NCAA
   CONCUSSION; LEAGUE PLAYERS; BODY-MASS; DEPRESSION; VALIDITY; RESERVE;
   IMPACT
AB Objective: Various concussion characteristics and personal factors are associated with cognitive recovery in athletes. We developed an index based on concussion frequency, severity, and timeframe, as well as cognitive reserve (CR), and we assessed its predictive power regarding cognitive ability in retired professional football players. Method: Data from 40 retired professional American football players were used in the current study. On average, participants had been retired from football for 20 years. Current neuropsychological performances, indicators of CR, concussion history, and play data were used to create an index for predicting cognitive outcome. Results: The sample displayed a range of concussions, concussion severities, seasons played, CR, and cognitive ability. Many of the participants demonstrated cognitive deficits. The index strongly predicted global cognitive ability (R-2 = .31). The index also predicted the number of areas of neuropsychological deficit, which varied as a function of the deficit classification system used (Heaton: R-2 = .15; Wechsler: R-2 = .28). Conclusions: The current study demonstrated that a unique combination of CR, sports concussion, and game-related data can predict cognitive outcomes in participants who had been retired from professional American football for an average of 20 years. Such indices may prove to be useful for clinical decision making and research.
C1 [Wright, Mathew J.; Birath, J. Brandon; Siders, Craig A.; Wang, Christina; Swerdloff, Ronald; Romero, Elizabeth] Harbor UCLA Med Ctr, Los Angeles Biomed Res Inst, Torrance, CA 90509 USA.
   [Wright, Mathew J.; Kernan, Claudia] Univ Calif Los Angeles, Sch Med, Dept Psychiat & Behav Sci, Los Angeles, CA 90024 USA.
   [Wright, Mathew J.; Birath, J. Brandon; Siders, Craig A.] Harbor UCLA Med Ctr, Dept Psychiat, Div Psychol, Torrance, CA 90509 USA.
   [Woo, Ellen] Univ Calif Los Angeles, Sch Med, Dept Neurol, Easton Ctr Alzheimers Dis Res, Los Angeles, CA USA.
   [Kelly, Daniel F.] St Johns Hlth Ctr, Brain Tumor Ctr, Santa Monica, CA USA.
   [Kelly, Daniel F.] St Johns Hlth Ctr, John Wayne Canc Inst, Pituitary Disorders Program, Santa Monica, CA USA.
   [Wang, Christina; Swerdloff, Ronald] Harbor UCLA Med Ctr, Dept Med, Div Endocrinol, Torrance, CA 90509 USA.
   [Cantu, Robert C.] Boston Univ, Sch Med, Boston, MA 02215 USA.
   [Guskiewicz, Kevin] Univ N Carolina, Ctr Study Retired Athletes, Chapel Hill, NC USA.
C3 Lundquist Institute; University of California System; University of
   California Los Angeles; University of California Los Angeles Medical
   Center; University of California System; University of California Los
   Angeles; University of California Los Angeles Medical Center; David
   Geffen School of Medicine at UCLA; University of California System;
   University of California Los Angeles; University of California Los
   Angeles Medical Center; University of California System; University of
   California Los Angeles; University of California Los Angeles Medical
   Center; David Geffen School of Medicine at UCLA; John Wayne Cancer
   Institute; University of California System; University of California Los
   Angeles; University of California Los Angeles Medical Center; Boston
   University; University of North Carolina; University of North Carolina
   Chapel Hill
RP Wright, MJ (corresponding author), Harbor UCLA Med Ctr, 1124 W Carson St B-4 South,Box 490, Torrance, CA 90502 USA.
EM mwright@labiomed.org
OI Cantu, Robert/0009-0002-4300-4063
FU National Operating Committee on Standards for Athletic Equipment;
   National Center for Research Resources, USA [M01 RR 19975]
FX This research was supported by National Operating Committee on Standards
   for Athletic Equipment and the National Center for Research Resources,
   USA [grant number M01 RR 19975].
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NR 54
TC 19
Z9 20
U1 0
U2 49
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1380-3395
EI 1744-411X
J9 J CLIN EXP NEUROPSYC
JI J. Clin. Exp. Neuropsychol.
PD MAY 27
PY 2016
VL 38
IS 5
BP 561
EP 571
DI 10.1080/13803395.2016.1139057
PG 11
WC Psychology, Clinical; Clinical Neurology; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Neurosciences & Neurology
GA DG4HN
UT WOS:000372033100007
PM 26898803
DA 2025-06-11
ER

PT J
AU Kim, JH
   Kim, DH
   Park, YS
AF Kim, Jeong-Hyeon
   Kim, Dong-Hyun
   Park, Yong Soon
TI Body Composition, Sarcopenia, and Suicidal Ideation in Elderly Koreans:
   Hallym Aging Study
SO JOURNAL OF KOREAN MEDICAL SCIENCE
LA English
DT Article
DE Suicide; Suicidal Ideation; Sarcopenia; Obesity; Elderly; Korean
ID METABOLIC SYNDROME; NATIONAL-HEALTH; MUSCLE MASS; OBESITY; RISK;
   DEPRESSION; ASSOCIATION; PREVALENCE; MORTALITY; DISORDER
AB This study was conducted to assess the relationship between body composition and suicidal ideation among the Korean elderly population (n = 302; >= 65 years) who participated in the Hallym Aging Study in 2010. Body composition was measured using dual-energy X-ray absorptiometry, and obesity was measured by the indices of body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR), waist-to-height ratio (WHtR), and body fat percentage. Sarcopenia was defined as presence of both low muscle mass and low muscle function. Suicidal ideation was assessed using the Beck Scale for Suicide Ideation. We found no differences in body composition measures between subjects with suicidal ideation and those without. In the logistic regression analyses, there were no significant relationships for suicidal ideation according to body composition measures, including BMI, WC, WHR, WHtR, and body fat percentage in both sexes. After adjusting for age, smoking status, alcohol drinking, regular exercise, medical comorbidities, monthly income, education level, and presence of depressive symptoms, the odds ratio (OR) of suicidal ideation was higher in elderly men with sarcopenia compared to those without, whereas no significant relationships were observed in elderly women (OR 8.28, 95% confidence interval [CI] 1.20-61.34 in men; OR 0.79, 95% CI 0.07-8.43 in women). Sarcopenia is closely associated with an increased risk of suicidal ideation in elderly men.
C1 [Kim, Jeong-Hyeon; Park, Yong Soon] Hallym Univ, Chuncheon Sacred Heart Hosp, Dept Family Med, Coll Med, 77 Sakju Ro, Chunchon 24253, South Korea.
   [Kim, Dong-Hyun] Hallym Univ, Dept Social & Prevent Med, Coll Med, Chunchon 24253, South Korea.
   [Kim, Dong-Hyun] Hallym Univ, Hallym Res Inst Clin Epidemiol, Coll Med, Chunchon 24253, South Korea.
C3 Hallym University; Hallym University; Hallym University
RP Park, YS (corresponding author), Hallym Univ, Chuncheon Sacred Heart Hosp, Dept Family Med, Coll Med, 77 Sakju Ro, Chunchon 24253, South Korea.
EM pyongs@hanmail.net
RI Kim, Dong/I-7600-2015
OI Kim, Dong-Hyun/0000-0002-1492-5253
CR Bae SM, 2013, J KOREAN MED SCI, V28, P602, DOI 10.3346/jkms.2013.28.4.602
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NR 33
TC 11
Z9 11
U1 0
U2 9
PU KOREAN ACAD MEDICAL SCIENCES
PI SEOUL
PA 302 75 DONG DU ICHON, DONG YONGSAN KU, SEOUL 140 031, SOUTH KOREA
SN 1011-8934
EI 1598-6357
J9 J KOREAN MED SCI
JI J. Korean Med. Sci.
PD APR
PY 2016
VL 31
IS 4
BP 604
EP 610
DI 10.3346/jkms.2016.31.4.604
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA DJ0YT
UT WOS:000373931000018
PM 27051246
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Jamil, H
   Dallo, F
   Fakhouri, M
   Templin, T
   Khoury, R
   Fakhouri, H
AF Jamil, Hikmet
   Dallo, Florence
   Fakhouri, Monty
   Templin, Thomas
   Khoury, Radwan
   Fakhouri, Haifa
TI THE PREVALENCE OF SELF-REPORTED CHRONIC CONDITIONS AMONG ARAB, CHALDEAN,
   AND AFRICAN AMERICANS IN SOUTHEAST MICHIGAN
SO ETHNICITY & DISEASE
LA English
DT Article
DE Arab; Chaldean; Black; Chronic Conditions
ID MULTIPLE CHRONIC CONDITIONS; RISK-FACTORS; METABOLIC SYNDROME;
   NATIONAL-HEALTH; UNITED-STATES; HYPERTENSION; EPIDEMIOLOGY; POPULATION;
   AWARENESS; VALIDITY
AB Objectives: While there is a plethora of research on the prevalence of individual chronic conditions, studies that examine the clustering of these conditions are lacking, especially among immigrant, minority groups.
   Design: Cross-sectional, convenience sample.
   Setting: A self-administered survey was distributed at churches, mosques, and small businesses.
   Participants: Arabs (n=1383), Chaldeans 0 868), Blacks (n=809) and Whites (n=220) in southeast Michigan.
   Main outcome measures: We estimated the prevalence of hypertension, high cholesterol, heart disease, diabetes, asthma, and depression. Using a logistic regression model, we estimated odds ratios and 95% confidence intervals for the association between ethnicity and reporting one or more chronic conditions before and after adjusting for demographic, socioeconomic status, health care, chronic conditions, and health behavior variables.
   Results: The overall age and sex-adjusted prevalence of having one or more chronic conditions was 44%. Estimates were lower for Chaldeans (32%) compared to Arabs (44%), Whites and Blacks (50% for each group). In the fully adjusted model, Chaldeans were less likely (OR=0.62; 95% CI=0.43-0.89) to report having one more chronic conditions compared to Whites.
   Conclusions: Future studies should employ probability samples, and should collect more detailed sociodemographic and acculturation data, which influence the relationship between race/ethnicity and the prevalence of chronic conditions. (Ethn Dis. 2009;19:293-300)
C1 [Jamil, Hikmet] Wayne State Univ, Div Occupat & Environm Hlth, Detroit, MI 48201 USA.
   [Dallo, Florence] Oakland Univ, Sch Hlth & Sci, Rochester, MI 48063 USA.
C3 Wayne State University; Oakland University
RP Jamil, H (corresponding author), Wayne State Univ, Div Occupat & Environm Hlth, 3800 Woodward Ave, Detroit, MI 48201 USA.
EM hjamil@med.wayne.edu
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NR 28
TC 15
Z9 17
U1 0
U2 10
PU INT SOC HYPERTENSION BLACKS-ISHIB
PI ATLANTA
PA 100 AUBURN AVE NE STE 401, ATLANTA, GA 30303-2527 USA
SN 1049-510X
J9 ETHNIC DIS
JI Ethn. Dis.
PD SUM
PY 2009
VL 19
IS 3
BP 293
EP 300
PG 8
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA 490QM
UT WOS:000269516400009
PM 19769012
DA 2025-06-11
ER

PT J
AU Pietowska, Z
   Nowicka, D
   Szepietowski, J
AF Pietowska, Zuzanna
   Nowicka, Danuta
   Szepietowski, Jacek
TI Can Biological Drugs Diminish the Risk of Sarcopenia in Psoriatic
   Patients? A Systematic Review
SO LIFE-BASEL
LA English
DT Article
DE sarcopenia; psoriasis; psoriatic arthritis; muscle loss; body
   composition; drugs intake; biological therapy
ID NECROSIS-FACTOR-ALPHA; BIOELECTRICAL PHASE-ANGLE; ASIAN WORKING GROUP;
   QUALITY-OF-LIFE; MUSCLE MASS; BODY-COMPOSITION; INSULIN SENSITIVITY;
   ADIPOSE-TISSUE; TNF-ALPHA; CARDIOVASCULAR-DISEASE
AB Sarcopenia and psoriasis are different inflammatory diseases that share common comorbidities (e.g., cardiovascular diseases, metabolic syndrome, obesity, autoimmune diseases, depression). Psoriasis is a dermatosis involving the skin, joints, and nails. Its estimated prevalence is 2-4%, and the possibility of progression to psoriatic arthritis reaches 6-42%. Sarcopenia is defined as reduced muscle strength, muscle quantity, and physical performance due to non-ageing related causes. It affects up to 10% of the general population. We conducted a review of the literature to provide up-to-date information about the risk of sarcopenia in psoriasis and to identify risk factors that increase this risk. The search of the literature allowed us to include 51 publications, but only five cross-sectional studies provided quantitative results on the rates of sarcopenia in psoriasis. The prevalence of sarcopenia in psoriasis varied from 9.1% to 61.7%. This wide range was caused by different definitions of sarcopenia and different cut-off values across studies. Prognostic factors include lean mass and fat mass. Further research based on the European Working Group on Sarcopenia in Older People guidelines is required. Such studies should include not only muscle mass and strength but also other factors that may influence the occurrence of sarcopenia and inflammatory markers.
C1 [Pietowska, Zuzanna; Nowicka, Danuta; Szepietowski, Jacek] Wroclaw Med Univ, Dept Dermatol Venereol & Allergol, PL-50368 Wroclaw, Poland.
C3 Wroclaw Medical University
RP Nowicka, D (corresponding author), Wroclaw Med Univ, Dept Dermatol Venereol & Allergol, PL-50368 Wroclaw, Poland.
EM zuzia.pietowska@gmail.com; danuta.nowicka@umw.edu.pl;
   jacek.szepietowski@umw.edu.pl
OI Nowicka, Danuta/0000-0002-1717-4280; Pietowska,
   Zuzanna/0000-0002-1593-1495; Szepietowski, Jacek/0000-0003-0766-6342
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NR 122
TC 4
Z9 4
U1 1
U2 5
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2075-1729
J9 LIFE-BASEL
JI Life-Basel
PD MAR
PY 2022
VL 12
IS 3
AR 435
DI 10.3390/life12030435
PG 13
WC Biology; Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Life Sciences & Biomedicine - Other Topics; Microbiology
GA 0C1TD
UT WOS:000775103300001
PM 35330186
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Grassi, D
   Necozione, S
   Desideri, G
   Abballe, S
   Mai, F
   De Feo, M
   Carducci, A
   Ferri, C
AF Grassi, Davide
   Necozione, Stefano
   Desideri, Giovambattista
   Abballe, Stefano
   Mai, Francesca
   De Feo, Martina
   Carducci, Augusto
   Ferri, Claudio
TI Acute and Long Term Effects of a Nutraceutical Combination on Lipid
   Profile, Glucose Metabolism and Vascular Function in Patients with
   Dyslipidaemia with and Without Cigarette Smoking
SO HIGH BLOOD PRESSURE & CARDIOVASCULAR PREVENTION
LA English
DT Article
DE Nutraceuticals; Hypercholesterolemia; Smoking; Flavonoids;
   Cardiovascular risk
ID FLOW-MEDIATED DILATION; ENDOTHELIAL DYSFUNCTION; CARDIOVASCULAR-DISEASE;
   OXIDATIVE STRESS; BLIND; RISK
AB Introduction Lifestyle changes present a fundamental role in cardiovascular prevention. Nutraceuticals also supplementing diet could help in controlling the cardiometabolic risk. Aim (1) to evaluate acute effects of a combination of nutraceuticals (cNUT) on vascular function, BP, metabolism in dyslipidaemic patients before and after smoking; (2) to evaluate 12 weeks effects of the cNUT on lipid profile, insulin resistance and vascular function in patients with hypercholesterolemia not on statins. Methods After 14 d run-in period, 33 patients assumed a cNUT [patented formula containing: berberine (531.25 mg), red yeast rice powder (220 mg, 3.3 mg monacolin K) and leaf extract of Morus alba (200 mg) (LopiGLIK(R), Akademy Pharma)]. To evaluate acute effects, cNUT or cNUT + smoking (in smoking subjects) on the morning of the first day of the study and then 26 patients prolonged 12 weeks effects. Results In non smokers, cNUT improved FMD (p = 0.041 for treatment). In smokers, FMD decreased after smoking, this was counteracted by intake of cNUT. In smokers, DBP increased after smoking a cigarette (p = 0.042 for treatment), counteracted by the cNUT intake. In non smokers, thermogenesis was increased after cNUT administration (p < 0.0001 for treatment). After 12 weeks of cNUT, FMD significantly increased (p < 0.05) and SBP (p = 0.04), total cholesterol and LDL cholesterol (p = 0.03) decreased. Conclusions Our study suggests benefits of cNUT on cardiovascular prevention in hypercolesterolemic patients, non statin treated, that goes beyond the cholesterol and insulin resistance reduction protecting the subject from negative effects induced by smoking too.
C1 [Grassi, Davide; Necozione, Stefano; Desideri, Giovambattista; Abballe, Stefano; Mai, Francesca; De Feo, Martina; Carducci, Augusto; Ferri, Claudio] Univ Aquila, Dept Life Hlth & Environm Sci, Viale S Salvatore,Delta 6 Med, I-67100 Coppito, Italy.
C3 University of L'Aquila
RP Grassi, D (corresponding author), Univ Aquila, Dept Life Hlth & Environm Sci, Viale S Salvatore,Delta 6 Med, I-67100 Coppito, Italy.
EM davide.grassi@univaq.it
RI Desideri, Giovambattista/AAB-5079-2022; Ferri, Claudio/AAB-5070-2022;
   Grassi, Davide/O-6519-2015
OI Grassi, Davide/0000-0003-1005-4689
FU Universita degli Studi dell'Aquila within the CRUI-CARE Agreement
FX Open access funding provided by Universita degli Studi dell'Aquila
   within the CRUI-CARE Agreement.
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NR 32
TC 4
Z9 4
U1 2
U2 2
PU ADIS INT LTD
PI NORTHCOTE
PA 5 THE WAREHOUSE WAY, NORTHCOTE 0627, AUCKLAND, NEW ZEALAND
SN 1120-9879
EI 1179-1985
J9 HIGH BLOOD PRESS CAR
JI High Blood Press. Cardiovasc. Prevent.
PD SEP
PY 2021
VL 28
IS 5
BP 483
EP 491
DI 10.1007/s40292-021-00468-4
EA SEP 2021
PG 9
WC Peripheral Vascular Disease
WE Emerging Sources Citation Index (ESCI)
SC Cardiovascular System & Cardiology
GA UZ7RC
UT WOS:000695403700002
PM 34519016
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Mötteli, S
   Provaznikova, B
   Vetter, S
   Jäger, M
   Seifritz, E
   Hotzy, F
AF Motteli, Sonja
   Provaznikova, Barbora
   Vetter, Stefan
   Jager, Matthias
   Seifritz, Erich
   Hotzy, Florian
TI Examining Nutrition Knowledge, Skills, and Eating Behaviours in People
   with Severe Mental Illness: A Cross-Sectional Comparison among
   Psychiatric Inpatients, Outpatients, and Healthy Adults
SO NUTRIENTS
LA English
DT Article
DE severe mental illness; psychiatry; depression; psychosis; health; diet;
   nutrition knowledge and skills; eating behaviour
ID VALIDATION; DISORDERS; WEIGHT; RISK; SCHIZOPHRENIA; INTERVENTIONS;
   ASSOCIATIONS; SCALE; FOOD
AB Compared to the general population, people with severe mental illness (SMI) have an increased risk of weight gain and metabolic syndrome, but also of malnutrition, in part due to unhealthy lifestyle behaviours. The aim of this cross-sectional study was to identify barriers to healthy eating, including nutrition knowledge and skills in people with SMI. For this purpose, we compared the means of anthropometric data such as body mass index, waist-to-hip ratio, and interview data on nutrition knowledge and skills, health-related variables, eating behaviours, personality, motivation, and attitudes in 65 inpatients and 67 outpatients of the Psychiatric Hospital of the University of Zurich and 64 healthy adults using ANOVA and chi-squared tests. The results showed that patients with SMI had worse nutritional status and lifestyle compared to the healthy controls, including disordered (e.g., night eating) and unhealthy (e.g., high intake of sugary foods) eating habits. However, levels of nutrition knowledge, cooking and food skills, and motivation to eat healthily were not significantly lower in the psychiatric patients than in the healthy adults and were not associated with weight change. Based on our findings, nutritional support for people with SMI is urgently needed and should include not only educational but also behavioural and long-term approaches.
C1 [Motteli, Sonja; Provaznikova, Barbora; Vetter, Stefan; Jager, Matthias; Seifritz, Erich; Hotzy, Florian] Univ Zurich, Psychiat Univ Hosp Zurich, Dept Psychiat Psychotherapy & Psychosomat, CH-8032 Zurich, Switzerland.
   [Motteli, Sonja] Univ Bern, Univ Hosp Psychiat & Psychotherapy, CH-3012 Bern, Switzerland.
   [Jager, Matthias] Psychiat Baselland, CH-4410 Liestal, Switzerland.
C3 University of Zurich; University of Bern; University Hospital of Bern
RP Hotzy, F (corresponding author), Univ Zurich, Psychiat Univ Hosp Zurich, Dept Psychiat Psychotherapy & Psychosomat, CH-8032 Zurich, Switzerland.
EM florian.hotzy@pukzh.ch
RI Vetter, Stefan/A-6930-2008; Jäger, Matthias/MGT-1993-2025
OI Motteli, Sonja/0000-0002-1055-7238; Hotzy, Florian/0000-0003-0661-9608
FU Foundation for the Encouragement of Nutrition Research in Switzerland
   (SFEFS) [551_Rev]
FX This research was partially funded by the Foundation for the
   Encouragement of Nutrition Research in Switzerland (SFEFS; grant number:
   551_Rev). The SFEFS was not involved in the chosen study design, data
   collection, analysis, or interpretation of the data, nor in the
   preparation, review, and approval of the manuscript.
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NR 51
TC 14
Z9 15
U1 1
U2 5
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD APR 29
PY 2023
VL 15
IS 9
AR 2136
DI 10.3390/nu15092136
PG 13
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA G2QT4
UT WOS:000987672300001
PM 37432259
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Vamecq, J
   Andreoletti, P
   El Kebbaj, R
   Saih, FE
   Latruffe, N
   El Kebbaj, MS
   Lizard, G
   Nasser, B
   Cherkaoui-Malki, M
AF Vamecq, Joseph
   Andreoletti, Pierre
   El Kebbaj, Riad
   Saih, Fatima-Ezzahra
   Latruffe, Norbert
   Said El Kebbaj, M'Hammed
   Lizard, Gerard
   Nasser, Boubker
   Cherkaoui-Malki, Mustapha
TI Peroxisomal Acyl-CoA Oxidase Type 1: Anti-Inflammatory and Anti-Aging
   Properties with a Special Emphasis on Studies with LPS and Argan Oil as
   a Model Transposable to Aging
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Review
ID POLYUNSATURATED FATTY-ACIDS; MYOCARDIAL ENERGY-METABOLISM;
   DOCOSAHEXAENOIC ACID; BETA-OXIDATION; INSULIN-RESISTANCE; MITOCHONDRIAL
   DYSFUNCTION; LIPID-ACCUMULATION; HEART-FAILURE; PGC-1-ALPHA; MICE
AB To clarify appropriateness of current claims for health and wellness virtues of argan oil, studies were conducted in inflammatory states. LPS induces inflammation with reduction of PGC1-alpha signaling and energy metabolism. Argan oil protected the liver against LPS toxicity and interestingly enough preservation of peroxisomal acyl-CoA oxidase type 1 (ACOX1) activity against depression by LPS. This model of LPS-driven toxicity circumvented by argan oil along with a key anti-inflammatory role attributed to ACOX1 has been here transposed to model aging. This view is consistent with known physiological role of ACOX1 in yielding precursors of specialized proresolving mediators (SPM) and with characteristics of aging and related disorders including reduced PGC1-a function and improvement by strategies rising ACOX1 (via hormonal gut FGF19 and nordihydroguaiaretic acid in metabolic syndrome and diabetes conditions) and SPM (neurodegenerative disorders, atherosclerosis, and stroke). Delay of aging to resolve inflammation results from altered production of SPM, SPM improving most aging disorders. The strategic metabolic place of ACOX1, upstream of SPM biosynthesis, along with ability of ACOX1 preservation/induction and SPM to improve aging-related disorders and known association of aging with drop in ACOX1 and SPM, all converge to conclude that ACOX1 represents a previously unsuspected and currently emerging antiaging protein.
C1 [Vamecq, Joseph] Univ Lille 2, INSERM, CHRU, HMNO,CBP, Lille, France.
   [Vamecq, Joseph] Univ Lille 2, Fac Med, EA 7364, RADEME, Lille, France.
   [Andreoletti, Pierre; Saih, Fatima-Ezzahra; Latruffe, Norbert; Lizard, Gerard; Cherkaoui-Malki, Mustapha] Univ Bourgogne Franche Comte, INSERM, Lab BioPeroxIL Biochimie Peroxysome Inflammat & M, EA 7270, Dijon, France.
   [El Kebbaj, Riad; Nasser, Boubker] Univ Hassan Premier, Inst Super Sci Sante, Lab Sci & Technol Sante, Settat, Morocco.
   [Saih, Fatima-Ezzahra] Univ Hassan I, Fac Sci & Tech, Lab Biochimie & Neurosci, Settat, Morocco.
   [Said El Kebbaj, M'Hammed] Univ Hassan II Mohammedia Casablanca, Fac Sci BenMsik, Lab Rech Lipoprot & Atherosclerose, Casablanca, Morocco.
C3 Institut National de la Sante et de la Recherche Medicale (Inserm);
   Universite de Lille; CHU Lille; Universite de Lille; Institut National
   de la Sante et de la Recherche Medicale (Inserm); Universite Bourgogne
   Europe; Hassan First University of Settat; Hassan First University of
   Settat; Hassan II University of Casablanca
RP Vamecq, J (corresponding author), Univ Lille 2, INSERM, CHRU, HMNO,CBP, Lille, France.; Vamecq, J (corresponding author), Univ Lille 2, Fac Med, EA 7364, RADEME, Lille, France.; Cherkaoui-Malki, M (corresponding author), Univ Bourgogne Franche Comte, INSERM, Lab BioPeroxIL Biochimie Peroxysome Inflammat & M, EA 7270, Dijon, France.
EM joseph.vamecq@inserm.fr; mustapha.cherkaoui-malki@u-bourgogne.fr
RI Lizard, Gerard/B-2439-2012; De Dios Alche, Juan/K-6079-2014; Vamecq,
   Joseph/M-4953-2018; Andreoletti, Pierre/B-5245-2012; Cherkaoui-Malki,
   Mustapha/B-2412-2012; El Kebbaj, Riad/ABB-5121-2021
OI Vamecq, Joseph/0000-0002-4089-7663; Andreoletti,
   Pierre/0000-0003-2118-7858; Cherkaoui-Malki,
   Mustapha/0000-0001-5010-739X; El Kebbaj, Riad/0000-0003-4965-2168; El
   kebbaj, Mhammed Said/0000-0002-0812-3158
FU Action Integree of the Comite Mixte Inter-universitaire Franco-Marocain
   (CMIFM, Campus France) [AIMA/14/310]; PHC Volubilis/Toubkal program
   [30293PA]; Ministry of Foreign Affairs; Centre National Pour la
   Recherche Scientifique et Technique (CNRST) Morocco; Conseil Regional de
   Bourgogne [PARI2012:A324, PARI2013:B135, CPS0009]; Ministere de
   l'enseignement et de la Recherche (credits recurrents); COST (European
   Cooperation in Science and Technology) Action [CA 16112 NutRedOx]
FX This work was supported by the Action Integree of the Comite Mixte
   Inter-universitaire Franco-Marocain (CMIFM, AIMA/14/310, Campus France)
   from the PHC Volubilis/Toubkal program (No30293PA), Ministry of Foreign
   Affairs, The Centre National Pour la Recherche Scientifique et Technique
   (CNRST) Morocco, the Conseil Regional de Bourgogne (PARI2012:A324;
   PARI2013:B135; CPS0009) and the Ministere de l'enseignement et de la
   Recherche (credits recurrents). The authors would like to acknowledge
   networking support by the COST (European Cooperation in Science and
   Technology) Action CA 16112 NutRedOx (Personalized Nutrition in aging
   society: redox control of major age-related diseases).
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NR 108
TC 30
Z9 32
U1 2
U2 21
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PY 2018
VL 2018
AR 6986984
DI 10.1155/2018/6986984
PG 13
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA GC3QB
UT WOS:000429697500001
PM 29765501
OA Green Published, Green Submitted, hybrid
DA 2025-06-11
ER

PT J
AU Gajewska, J
   Chelchowska, M
   Ambroszkiewicz, J
   Riahi, A
   Weker, H
   Szamotulska, K
AF Gajewska, Joanna
   Chelchowska, Magdalena
   Ambroszkiewicz, Jadwiga
   Riahi, Agnieszka
   Weker, Halina
   Szamotulska, Katarzyna
TI Changes in Oxidized Low-Density Lipoprotein Rather Than in Paraoxonase1
   are Associated with Changes in the Leptin/Leptin Receptor Ratio in Obese
   Children During Weight-Loss Therapy
SO EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
LA English
DT Article
DE ox-LDL; PON1; anti ox-LDL; adipokines; prepubertal period
ID LIFE-STYLE INTERVENTION; INTIMA-MEDIA THICKNESS; OXIDATIVE STRESS;
   CARDIOMETABOLIC RISK; INSULIN-RESISTANCE; CHILDHOOD OBESITY; LEPTIN;
   LDL; INFLAMMATION; MARKERS
AB Background Oxidative stress and impaired production of adipokines in childhood obesity contribute to the development of obesity-related disorders. We assessed whether weight loss after lifestyle intervention alters biomarkers of oxidant/antioxidant status, and whether these alterations are associated with changes in anthropometric parameters and adipokines in obese children.
   Materials and Methods We determined oxidized low-density lipoprotein (ox-LDL), anti ox-LDL, paraoxonase1 (PON1), leptin, soluble leptin receptor (sOB-R), total adiponectin, high molecular weight adiponectin concentrations and body composition (by dual-energy X-ray absorptiometry) in 60 prepubertal obese children (Body Mass Index, BMI Z-score > 2) before and after a 3-month intervention. The control group consisted of 44 non-obese children (BMI Z-score < - 1 + 1 > ).
   Results Ox-LDL, ox-LDL/LDL, and anti ox-LDL concentrations as well as leptin to sOb-R ratio were reduced (p < 0.001; p = 0.018; p < 0.001; p < 0.001, respectively) in obese children with weight loss (BMI Z-score change <= - 0.5) after a 3-month therapy. These parameters were stable in the obese group without weight loss (BMI Z-score change > - 0.5). Changes in ox-LDL and PON1 levels in all obese children correlated positively with changes in the leptin to sOB-R ratio (r = 0.400, p = 0.002; r = 0.304, p = 0.028, respectively). After adjustment for changes in BMI Z-score in the multivariate regression model, the association between the changes in ox-LDL levels and changes in the leptin/sOb-R ratio remained statistically significant (beta = 0.184, p = 0.014).
   Conclusions We found out that a 3-month lifestyle intervention associated with weight loss improves the oxidant/antioxidant balance and promotes anti-atherogenic changes in prepubertal obese children in a way dependent on the alterations in the leptin to sOB-R ratio.
C1 [Gajewska, Joanna; Chelchowska, Magdalena; Ambroszkiewicz, Jadwiga] Inst Mother & Child Hlth, Screening Dept & Metab Diagnost, Kasprzaka 17a, PL-01211 Warsaw, Poland.
   [Riahi, Agnieszka; Weker, Halina] Inst Mother & Child Hlth, Dept Nutr, Warsaw, Poland.
   [Szamotulska, Katarzyna] Inst Mother & Child Hlth, Dept Epidemiol & Biostat, Warsaw, Poland.
RP Gajewska, J (corresponding author), Inst Mother & Child Hlth, Screening Dept & Metab Diagnost, Kasprzaka 17a, PL-01211 Warsaw, Poland.
EM joanna.gajewska@imid.med.pl
RI Weker, Halina/N-3714-2018; Szamotulska, Katarzyna/K-2303-2012;
   Ambroszkiewicz, Jadwiga/W-1516-2018; Chelchowska, Magdalena/Y-2951-2018;
   Gajewska, Joanna/F-2414-2019
OI Szamotulska, Katarzyna/0000-0003-1045-7584; Ambroszkiewicz,
   Jadwiga/0000-0001-7320-7561; Chelchowska, Magdalena/0000-0002-6174-6813;
   Gajewska, Joanna/0000-0002-1349-0155; Weker, Halina/0000-0002-5072-2066
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PU JOHANN AMBROSIUS BARTH VERLAG MEDIZINVERLAGE HEIDELBERG GMBH
PI STUTTGART
PA RUEDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0947-7349
EI 1439-3646
J9 EXP CLIN ENDOCR DIAB
JI Exp. Clin. Endocrinol. Diabet.
PD MAY
PY 2019
VL 127
IS 5
BP 267
EP 275
DI 10.1055/a-0723-3951
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA HX1CV
UT WOS:000467127900001
PM 30235491
DA 2025-06-11
ER

PT J
AU Victor, VM
   Rovira-Llopis, S
   Banuls, C
   Diaz-Morales, N
   de Marañon, AM
   Rios-Navarro, C
   Alvarez, A
   Gomez, M
   Rocha, M
   Hernández-Mijares, A
AF Victor, Victor M.
   Rovira-Llopis, Susana
   Banuls, Celia
   Diaz-Morales, Noelia
   Martinez de Maranon, Arantxa
   Rios-Navarro, Cesar
   Alvarez, Angeles
   Gomez, Marcelino
   Rocha, Milagros
   Hernandez-Mijares, Antonio
TI Insulin Resistance in PCOS Patients Enhances Oxidative Stress and
   Leukocyte Adhesion: Role of Myeloperoxidase
SO PLOS ONE
LA English
DT Article
ID POLYCYSTIC-OVARY-SYNDROME; LEUKOCYTE/ENDOTHELIAL CELL-INTERACTIONS;
   GRADE CHRONIC INFLAMMATION; METABOLIC SYNDROME; ENDOTHELIAL DYSFUNCTION;
   CARDIOVASCULAR RISK; GLYCEMIC CONTROL; WOMEN; NEUTROPHILS; EXPRESSION
AB Cardiovascular diseases and oxidative stress are related to polycystic ovary syndrome (PCOS) and insulin resistance (IR). We have evaluated the relationship between myeloperoxidase (MPO) and leukocyte activation in PCOS patients according to homeostatic model assessment of IR (HOMA-IR), and have explored a possible correlation between these factors and endocrine and inflammatory parameters. This was a prospective controlled study conducted in an academic medical center. The study population consisted of 101 PCOS subjects and 105 control subjects. We divided PCOS subjects into PCOS non-IR (HOMA-IR<2.5) and PCOS IR (HOMA-IR>2.5). Metabolic and anthropometric parameters, total and mitochondrial reactive oxygen species (ROS) production, MPO levels, interactions between human umbilical vein endothelial cells and leukocytes, adhesion molecules (E-selectin, ICAM-1 and VCAM-1) and proinflammatory cytokines (IL-6 and TNF-alpha) were evaluated. Oxidative stress was observed in PCOS patients, in whom there was an increase in total and mitochondrial ROS production and MPO levels. Enhanced rolling flux and adhesion, and a decrease in polymorphonuclear cell rolling velocity were also detected in PCOS subjects. Increases in IL-6 and TNF-alpha and adhesion molecules (E-selectin, ICAM-1 and VCAM-1) were also observed, particularly in the PCOS IR group, providing evidence that inflammation and oxidative stress are related in PCOS patients. HOMA-IR was positively correlated with hsCRP (p<0.001, r = 0.304), ROS production (p<0.01, r = 0.593), leukocyte rolling flux (p<0.05, r = 0.446), E-selectin (p<0.01, r = 0.436) and IL-6 (p<0.001, r = 0.443). The results show an increase in the rate of ROS and MPO levels in PCOS patients in general, and particularly in those with IR. Inflammation in PCOS induces leukocyte-endothelium interactions and a simultaneous increase in IL-6, TNF-alpha, E-selectin, ICAM-1 and VCAM-1. These conditions are aggravated by the presence of IR.
C1 [Victor, Victor M.; Rovira-Llopis, Susana; Banuls, Celia; Diaz-Morales, Noelia; Martinez de Maranon, Arantxa; Gomez, Marcelino; Rocha, Milagros; Hernandez-Mijares, Antonio] Univ Hosp Doctor Peset, Serv Endocrinol, Fdn Promot Hlth & Biomed Res Valencian Reg FISABI, Valencia, Spain.
   [Victor, Victor M.; Rovira-Llopis, Susana; Banuls, Celia; Rocha, Milagros; Hernandez-Mijares, Antonio] Univ Valencia, Inst Hlth Res INCLIVA, Valencia, Spain.
   [Victor, Victor M.; Rios-Navarro, Cesar; Alvarez, Angeles; Rocha, Milagros] Univ Valencia, CIBERehd Dept Pharmacol & Physiol, Valencia, Spain.
   [Victor, Victor M.] Univ Valencia, Dept Physiol, Valencia, Spain.
   [Alvarez, Angeles] Univ Valencia, Gen Fdn, Valencia, Spain.
   [Hernandez-Mijares, Antonio] Univ Valencia, Dept Med, Valencia, Spain.
C3 University of Valencia; CIBER - Centro de Investigacion Biomedica en
   Red; CIBEREHD; University of Valencia; University of Valencia;
   University of Valencia; University of Valencia
RP Victor, VM; Rocha, M; Hernández-Mijares, A (corresponding author), Univ Hosp Doctor Peset, Serv Endocrinol, Fdn Promot Hlth & Biomed Res Valencian Reg FISABI, Valencia, Spain.; Victor, VM; Rocha, M; Hernández-Mijares, A (corresponding author), Univ Valencia, Inst Hlth Res INCLIVA, Valencia, Spain.; Victor, VM; Rocha, M (corresponding author), Univ Valencia, CIBERehd Dept Pharmacol & Physiol, Valencia, Spain.; Victor, VM (corresponding author), Univ Valencia, Dept Physiol, Valencia, Spain.; Hernández-Mijares, A (corresponding author), Univ Valencia, Dept Med, Valencia, Spain.
EM Victor.Victor@uv.es; milagros.rocha@uv.es; hernandez_antmij@gva.es
RI VICTOR, VICTOR/I-3270-2015; Alvarez, Angeles/ABF-4589-2020; Rocha,
   Milagros/I-4987-2015; Banuls, Celia/H-7359-2017; Diaz-Morales,
   Noelia/H-1978-2015; Rovira-Llopis, Susana/AAX-8666-2021; Martinez de
   Maranon Peris, Aranzazu/H-4399-2017; Rios-Navarro, Cesar/AAB-3875-2019
OI Rocha, Milagros/0000-0003-2923-6546; Banuls, Celia/0000-0001-8077-7642;
   Diaz-Morales, Noelia/0000-0003-1657-2700; Alvarez,
   Angeles/0000-0002-2301-9746; Rovira-Llopis, Susana/0000-0002-8476-5128;
   VICTOR, VICTOR/0000-0002-3027-3945; Martinez de Maranon Peris,
   Aranzazu/0000-0002-4153-0396; Rios-Navarro, Cesar/0000-0002-6405-6279
FU European Regional Development Fund (ERDF "A way to build Europe");
   Ministry of Health of the Valencian Regional Government; Carlos III
   Health Institute [CES10/030, CP10/0360, FI11/00637, CD14/00043,
   FI14/00125]; Conselleria de Educacion, Cultura y Deporte [CPI-13-194];
   Ministerio de Ciencia e Innovacion [RYC2005-002295];  [PI12/1984]; 
   [PI13/1025];  [PI13/0073];  [PI15/1424];  [CIBERehd CB06/04/0071]; 
   [PROMETEOII2014/035];  [SAF2010/16030];  [UGP-14-93];  [UGP-14-95]
FX This study was financed by grants PI12/1984, PI13/1025, PI13/0073,
   PI15/1424, CIBERehd CB06/04/0071, PROMETEOII2014/035, SAF2010/16030,
   UGP-14-93, UGP-14-95 and by the European Regional Development Fund (ERDF
   "A way to build Europe"). VMV and MR are recipients of contracts from
   the Ministry of Health of the Valencian Regional Government and Carlos
   III Health Institute (CES10/030 and CP10/0360, respectively). SR-L is
   the recipient of a predoctoral fellowship from Carlos III Health
   Institute (FI11/00637). CB is the recipient of a postdoctoral contract
   from Carlos III Health Institute (CD14/00043). ND-M is the recipient of
   a predoctoral contract from Carlos III Health Institute (FI14/00125).
   CR-N was supported by Conselleria de Educacion, Cultura y Deporte
   (CPI-13-194). AA was supported by Ministerio de Ciencia e Innovacion
   (Ramon y Cajal program RYC2005-002295 and I3 program).
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NR 44
TC 94
Z9 100
U1 0
U2 18
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAR 23
PY 2016
VL 11
IS 3
AR e0151960
DI 10.1371/journal.pone.0151960
PG 16
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA DH3QJ
UT WOS:000372701200078
PM 27007571
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Sam-Yellowe, TY
AF Sam-Yellowe, Tobili Y.
TI Nutritional Barriers to the Adherence to the Mediterranean Diet in
   Non-Mediterranean Populations
SO FOODS
LA English
DT Review
DE Mediterranean diet; dietary pattern; food barriers; nutrition education;
   public health nutrition; food insecurity; racial/ethnic minorities; diet
   of Crete; Blue Zone diet; Native American diet
ID QUALITY INDEXES; METABOLIC SYNDROME; STYLE DIET;
   CARDIOVASCULAR-DISEASES; RACIAL-DIFFERENCES; AMERICAN WOMEN; RISK;
   SCORE; STROKE; HEALTH
AB Adherence to the Mediterranean diet has been shown to lower the risk of developing chronic non-communicable diseases like cardiovascular and neurodegenerative diseases and cancer. Improvements in depression, participation in daily activities in older individuals, weight loss and a reduction in adverse pregnancy outcomes are associated with adherence to the Mediterranean diet. The number of studies that have evaluated barriers to adherence to the Mediterranean diet in the US and, in particular, in racial and ethnic minority populations within the US are few. Among Native American and Alaskan Native populations, studies evaluating traditional or alternative Mediterranean diet adherence for chronic non-infectious diseases is unavailable. Mediterranean diet scoring instruments used in studies in European and Mediterranean countries and among white participants in the US fail to capture the dietary patterns of racial and ethnic minority populations. In this narrative review, the food components of the traditional Mediterranean diet are discussed, adherence to the Mediterranean diet is examined in Mediterranean and non-Mediterranean countries and barriers preventing adherence to the Mediterranean diet in the US and among racial and ethnic minority populations is reviewed. Recommendations for improving nutrition education and intervention and for increasing adherence and cultural adaptions to the Mediterranean diet are provided.
C1 [Sam-Yellowe, Tobili Y.] Canisius Univ, Grad Coll, 2001 Main St, Buffalo, NY 14208 USA.
   [Sam-Yellowe, Tobili Y.] Cleveland State Univ, Dept Biol Geol & Environm Sci, 2121 Euclid Ave, Cleveland, OH 44115 USA.
C3 University System of Ohio; Cleveland State University
RP Sam-Yellowe, TY (corresponding author), Canisius Univ, Grad Coll, 2001 Main St, Buffalo, NY 14208 USA.; Sam-Yellowe, TY (corresponding author), Cleveland State Univ, Dept Biol Geol & Environm Sci, 2121 Euclid Ave, Cleveland, OH 44115 USA.
EM t.sam-yellowe@csuohio.edu
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NR 162
TC 8
Z9 8
U1 9
U2 15
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2304-8158
J9 FOODS
JI Foods
PD JUN
PY 2024
VL 13
IS 11
AR 1750
DI 10.3390/foods13111750
PG 34
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA UB3P6
UT WOS:001245566400001
PM 38890978
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Godoy-Matos, AF
   Vieira, AR
   Moreira, RO
   Coutinho, WF
   Carrao, LM
   Moreira, DM
   Pasquali, R
   Meirelles, RMR
AF Godoy-Matos, AF
   Vieira, AR
   Moreira, RO
   Coutinho, WF
   Carrao, LM
   Moreira, DM
   Pasquali, R
   Meirelles, RMR
TI The potential role of increased adrenal volume in the pathophysiology of
   obesity-related Type 2 diabetes
SO JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
LA English
DT Article
DE adrenal volume; obesity; Type 2 diabetes mellitus; visceral fat
ID INSULIN-RESISTANCE; METABOLIC SYNDROME; ABDOMINAL OBESITY; FAT
   DISTRIBUTION; GLAND VOLUME; CORTISOL; AXIS; ABNORMALITIES; DEPRESSION;
   MELLITUS
AB The hypothalamic-pituitary-adrenal (HPA) axis seems to play an important role in obesity and Type 2 diabetes (DM). The aim of the present study was to determine the adrenal volume in obese patients with DIM in comparison to obese non-diabetic patients. Eleven diabetic obese and 19 non-diabetic obese women were sequentially invited to take part in the study. Computed tomography (CT) scan of the abdomen was performed to determine adrenal volume, visceral (VF) and sc fat (SCF). Daily urinary free cortisol (UFC) was used as a measure of integrated cortisol production. In the diabetic patients, hemoglobin A(1c) was measured as an index of metabolic control. Compared to non-diabetic controls, patients with diabetes had a significantly higher total adrenal volume (4.29 +/- 1.50 vs 2.95 +/- 1.64; p=0.03). A highly significant correlation was detected between VF and VF/SCF ratio and total adrenal volume in the whole group (r=0.36, p=0.04 and r=0.48, p=0.008, respectively). This study, therefore, suggests an association between abdominal obesity, enlarged adrenals and Type 2 diabetes. These findings support the hypothesis that an increased activity of the HPA axis in obese subjects may be involved in the pathogenesis of Type 2 diabetes.
C1 Univ Fed Rio de Janeiro, Inst Estadual Diabet & Endocrinol, BR-20211340 Rio De Janeiro, Brazil.
   Univ Fed Rio de Janeiro, Dept Radiol, BR-20211340 Rio De Janeiro, Brazil.
   Univ Alma Mater Studiorum, S Orsola Malpighi Hosp, Div Endocrinol, Bologna, Italy.
C3 Universidade Federal do Rio de Janeiro; Universidade Federal do Rio de
   Janeiro; IRCCS Azienda Ospedaliero-Universitaria di Bologna; University
   of Bologna
RP Godoy-Matos, AF (corresponding author), Univ Fed Rio de Janeiro, Inst Estadual Diabet & Endocrinol, Rua Moncorvo Filho 90, BR-20211340 Rio De Janeiro, Brazil.
EM godoymatos@openlink.com.br
RI Meirelles, Ricardo/L-6800-2019; Moreira, Rodrigo/N-7131-2015
OI Godoy-Matos, Amelio/0000-0001-9089-9889
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NR 22
TC 28
Z9 32
U1 0
U2 2
PU EDITRICE KURTIS S R L
PI MILAN
PA VIA LUIGI ZOJA 30, 20153 MILAN, ITALY
SN 0391-4097
J9 J ENDOCRINOL INVEST
JI J. Endocrinol. Invest.
PD FEB
PY 2006
VL 29
IS 2
BP 159
EP 163
DI 10.1007/BF03344090
PG 5
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 023IA
UT WOS:000236119100010
PM 16610243
DA 2025-06-11
ER

PT J
AU Gazdzinska, AP
   Gazdzinski, SP
   Jagielski, P
   Wylezol, M
AF Gazdzinska, Agata P.
   Gazdzinski, Stefan P.
   Jagielski, Pawel
   Wylezol, Mariusz
TI Health Behaviors of Patients Qualified for Bariatric Surgery: The Role
   of Excess Body Weight, Age, and Depressive Symptoms
SO BARIATRIC SURGICAL PRACTICE AND PATIENT CARE
LA English
DT Article
DE morbid obesity; health behaviors; nutrition habits; depressive symptoms;
   bariatric surgery
ID PHYSICAL-ACTIVITY; METABOLIC SYNDROME; NATIONAL-HEALTH; UNITED-STATES;
   US ADULTS; OBESITY; ASSOCIATION; WOMEN; PREVALENCE; OVERWEIGHT
AB Introduction: Health behaviors exhibited by patients qualified for bariatric surgery has never been evaluated simultaneously with depressive symptoms. Objectives: To compare the health behaviors of obese patients with the general Polish population and establish their associations with demographic and clinical factors. Subjects and Methods: Proper nutrition habits, preventive behaviors, health practices, and positive mental attitude were evaluated with the Juczynski Health Behaviors. Inventory in 93 patients (66 females) qualified for bariatric surgery (44.211.5 years, body mass index [BMI]=44.310.5, percent excess body weight [%EBW]=81%+/- 39%), and depressive symptoms were assessed with the Beck Depression Inventory. Results: Scores obtained are similar to those of the general Polish population. Women scored higher in the proper nutrition habit category than men (p=0.02), but they scored lower in health practices and positive mental attitude than women in the general population. Higher severity of depressive symptoms negatively correlated with proper eating habits (R=-0.21; p=0.04). Higher BMI and higher %EBW were correlated to higher scores in health practices (R>0.24, p=0.02), independent of age. Conclusions: Generally, associations between health behaviors, BMI, and %EBW are weakly positive or absent. Therefore, they either do not contribute to the development of obesity or they might be adopted by patients once the disease is underway.
C1 [Gazdzinska, Agata P.] Mil Inst Aviat Med, Dept Nutr & Obes, 54-56 Krasinskiego St, PL-01755 Warsaw, Poland.
   [Gazdzinski, Stefan P.] Mil Inst Aviat Med, Dept Magnet Resonance, Warsaw, Poland.
   [Jagielski, Pawel] Jagiellonian Univ, Coll Med, Fac Hlth Sci, Dept Human Nutr, Krakow, Poland.
   [Wylezol, Mariusz] Mil Inst Aviat Med, Dept Surg, Warsaw, Poland.
C3 Military Institute of Aviation Medicine; Military Institute of Aviation
   Medicine; Jagiellonian University; Collegium Medicum Jagiellonian
   University; Military Institute of Aviation Medicine
RP Gazdzinska, AP (corresponding author), Mil Inst Aviat Med, Dept Nutr & Obes, 54-56 Krasinskiego St, PL-01755 Warsaw, Poland.
EM afrotena@gmail.com
RI Gazdzinski, Stefan/HZL-1869-2023; Gaździńska, Agata/GZM-2291-2022;
   Jagielski, Pawel/U-4944-2018
OI Jagielski, Pawel/0000-0001-7583-8965; Gazdzinski,
   Stefan/0000-0003-0740-8765
FU Polish National Science Centre (NCN) [2013/09/B/NZ7/03763]
FX The study was partially supported by Polish National Science Centre
   (NCN) for partial support under grant 2013/09/B/NZ7/03763.
CR [Anonymous], DEPRESSION INVENTORY
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NR 36
TC 0
Z9 0
U1 0
U2 6
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 2168-023X
EI 2168-0248
J9 BARIATR SURG PRACT P
JI Bariatr. Surg. Pract. Patient Care
PD MAR
PY 2018
VL 13
IS 1
BP 38
EP 43
DI 10.1089/bari.2017.0027
EA FEB 2018
PG 6
WC Nursing; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Surgery
GA GC2CV
UT WOS:000424154900001
DA 2025-06-11
ER

PT J
AU Batista, GMS
   Rocha, HNM
   Storch, AS
   Garcia, VP
   Teixeira, GF
   Mentzinger, J
   Gome, EAC
   Velasco, LL
   Nóbreg, ACL
   Rocha, NG
AF Batista, G. M. S.
   Rocha, H. N. M.
   Storch, A. S.
   Garcia, V. P.
   Teixeira, G. F.
   Mentzinger, J.
   Gome, E. A. C.
   Velasco, L. L.
   Nobreg, A. C. L.
   Rocha, N. G.
TI Ascorbic acid inhibits vascular remodeling induced by mental stress in
   overweight/obese men
SO LIFE SCIENCES
LA English
DT Article
DE Obesity; Ascorbic acid; Vascular remodeling; Oxidative stress
ID ENDOTHELIAL DYSFUNCTION; MATRIX METALLOPROTEINASE-2; NADPH OXIDASE;
   METABOLIC SYNDROME; OXIDATIVE STRESS; NITRIC-OXIDE; CELLS; SUPEROXIDE;
   EXPRESSION; EXERCISE
AB Background: Mental stress (MS) is related to endothelial dysfunction in overweight/obese men. It is believed that the pro-oxidant profile, associated with an imbalance in the vascular remodeling process, may contribute to deleterious effects of MS on endothelial function. However, it is unknown whether administration of ascorbic acid (AA), a potent antioxidant, can prevent oxidative and remodeling dysfunction during MS in these subjects.
   Methods: Fourteen overweight/obese grade I men (27 +/- 7 years; 29.7 +/- 2.6 kg.m(-2)) underwent the Stroop Color Word Test for 5 min to induce MS after AA (3 g) or placebo (PL, 0.9% NaCl) intravenous infusions. Venous blood samples were collected at baseline and the last minute of MS to measure nitrite concentration (chemiluminescence), protein carbonylation, thiobarbituric acid reactive substances (TBARS) and catalase activity (colorimetric assays), superoxide dismutase (SOD; immunoenzymatic assay), activities of active/inactive (pro) forms of metalloproteinases-9 and -2 (MMP; zymography) and its respective tissue inhibitors concentration (TIMP-1 and TIMP-2; immunoenzymatic assays).
   Results: At baseline, MMP-9 activity (p < 0.01), the MMP-9/proMMP-9 ratio (p = 0.02) and TIMP-1 concentration (p = 0.05) were reduced, whereas proMPP-9 activity was increased (p = 0.02) after AA compared to PL infusion. After PL infusion, MS increased protein carbonylation (p < 0.01), catalase (p < 0.01), and the MMP-9/proMMP-9 ratio (p = 0.04) when compared to baseline. AA infusion reduced protein carbonylation (p = 0.02), MMP-9 activity (p < 0.01), and MMP-9/pro-MMP-9 ratio (p < 0.01), while SOD (p = 0.04 vs baseline), proMPP-9 (p < 0.01 vs PL), MMP-2 (p < 0.01 vs PL) and TIMP-2 (p = 0.02 vs baseline) remained elevated during MS.
   Conclusions: AA appears to minimize the oxidative imbalance and vascular remodeling induced by MS.
C1 [Batista, G. M. S.; Rocha, H. N. M.; Storch, A. S.; Garcia, V. P.; Teixeira, G. F.; Mentzinger, J.; Velasco, L. L.; Rocha, N. G.] Fluminense Fed Univ, Dept Physiol & Pharmacol, Lab Integrat Cardiometabol, Niteroi, RJ, Brazil.
   [Batista, G. M. S.; Rocha, H. N. M.; Storch, A. S.; Garcia, V. P.; Teixeira, G. F.; Mentzinger, J.; Gome, E. A. C.; Velasco, L. L.; Nobreg, A. C. L.; Rocha, N. G.] Fluminense Fed Univ, Dept Physiol & Pharmacol, Lab Exercise Sci, Niteroi, RJ, Brazil.
C3 Universidade Federal Fluminense; Universidade Federal Fluminense
RP Rocha, NG (corresponding author), Fluminense Fed Univ, Dept Physiol & Pharmacol, 101 Hernani Pires de Melo St,Suite 106, BR-24210130 Niteroi, RJ, Brazil.
EM nataliagalito@id.uff.br
RI Pacheco Garcia, Vinicius/ABE-2776-2020; Rocha, Natalia
   Galito/AAN-7903-2020; Storch, Amanda/G-9080-2017; Rocha,
   Helena/B-9530-2018
OI Rocha, Natalia Galito/0000-0002-1990-9834; ,
   Larissa/0000-0003-1907-5021; Storch, Amanda/0000-0003-4666-8359; Pacheco
   Garcia, Vinicius/0000-0003-3022-1616; Batista,
   Gabriel/0000-0002-1542-5242; Fernandes Teixeira,
   Gabriel/0000-0002-7078-1880; Rocha, Helena/0000-0002-4741-7343
FU Brazilian National Council of Scientific and Technological Development
   (CNPq) [Universal: 462265/2014-5]; Foundation for Research Support of
   Rio de Janeiro (FAPERJ) [APQ 1: E-26/111.339/2014]; Coordination for the
   Improvement of Higher Education Personnel (CAPES)
FX This study was supported by grants from the Brazilian National Council
   of Scientific and Technological Development (CNPq; Universal:
   462265/2014-5), the Foundation for Research Support of Rio de Janeiro
   (FAPERJ; APQ 1: E-26/111.339/2014), and the Coordination for the
   Improvement of Higher Education Personnel (CAPES).
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NR 58
TC 6
Z9 7
U1 0
U2 0
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0024-3205
EI 1879-0631
J9 LIFE SCI
JI Life Sci.
PD JUN 1
PY 2020
VL 250
AR 117554
DI 10.1016/j.lfs.2020.117554
PG 8
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA LK2SC
UT WOS:000530710200019
PM 32184123
OA hybrid
DA 2025-06-11
ER

PT J
AU Lavie, CJ
   Kuruvanka, T
   Milani, RV
   Prasad, A
   Ventura, HO
AF Lavie, CJ
   Kuruvanka, T
   Milani, RV
   Prasad, A
   Ventura, HO
TI Exercise capacity in adult African-Americans referred for exercise
   stress testing - Is fitness affected by race?
SO CHEST
LA English
DT Article
DE aging; exercise testing; fitness; obesity; race
ID ALL-CAUSE MORTALITY; BODY-MASS INDEX; PHYSICAL-FITNESS; PROGNOSTIC
   VALUE; CARDIORESPIRATORY FITNESS; CARDIAC REHABILITATION;
   CARDIOVASCULAR-DISEASE; FUNCTIONAL-CAPACITY; METABOLIC SYNDROME;
   UNITED-STATES
AB Study objectives: To determine the factors associated with exercise capacity.
   Design: Retrospective evaluation of large stress-testing database.
   Setting: Multispecialty tertiary care center.
   Patients: A total of 5,069 consecutive patients who were referred for exercise stress testing.
   Measurements: We compared levels of fitness in 641 African-Americans (52% male) with 4,428 whites (73% male), and performed univariate and multivariate analyses to determine the predictors of fitness (including race).
   Results: Compared with African-American men (mean [+/- SD] age, 60 +/- 11 years), white men (mean age, 63 +/- 11 years) have significantly higher exercise capacity (10.7 +/- 3.5 vs 11.4 +/- 3.4 metabolic equivalents [METs], respectively; p < 0.001). The exercise capacity in African-American and white women was similar (8.5 +/- 2.9 vs 8.7 +/- 3.0 METs, respectively). However, body mass indexes (BMIs) were significantly higher in both African-American men (29.1 +/- 4.3 vs 28.2 +/- 4.3 kg/m(2), respectively; p < 0.001) and women (30.2 +/- 5.7 vs 27.9 +/- 5.5 kg/m(2), respectively; p < 0.0001) compared to their white counterparts, as was the prevalence of obesity (men, 44% vs 33%, respectively; women, 37% vs 27%, respectively; both p < 0.001). Although a model containing age, gender, BMI, and race only accounted for 32% of exercise capacity, all independently (p < 0.0001) predicted higher exercise capacity, as follows: younger age (r(2) = 0.14); male gender (r(2) = 0.12); BNH (r(2) = 0.06); and white race (r(2) = 0.004).
   Conclusions: In an adult population of individuals who were referred for exercise stress testing, African-Americans were more obese and had significantly lower exercise capacity than their white counterparts. Emphasis on weight reduction and increasing physical fitness is particularly needed for the prevention of cardiovascular diseases in African-Americans.
C1 Alton Ochsner Med Fdn & Ochsner Clin, Ochsner Heart & Vasc Inst, New Orleans, LA 70121 USA.
C3 Ochsner Health System
RP Alton Ochsner Med Fdn & Ochsner Clin, Ochsner Heart & Vasc Inst, 1514 Jefferson Highway, New Orleans, LA 70121 USA.
EM clavie@ochsner.org
RI Lavie, Carl/A-6014-2011; Milani, Richard/AAS-7955-2020
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NR 44
TC 44
Z9 51
U1 0
U2 3
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0012-3692
EI 1931-3543
J9 CHEST
JI Chest
PD DEC
PY 2004
VL 126
IS 6
BP 1962
EP 1968
DI 10.1378/chest.126.6.1962
PG 7
WC Critical Care Medicine; Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Respiratory System
GA 879YI
UT WOS:000225754900041
PM 15596699
DA 2025-06-11
ER

PT J
AU Bispo, P
   Rodrigues, PO
   Bandarra, NM
AF Bispo, Paulo
   Rodrigues, Pedro O.
   Bandarra, Narcisa M.
TI Dietary Oleic Acid and SCD16 and ELOVL6 Estimated Activities Can Modify
   Erythrocyte Membrane n-3 and n-6 HUFA Partition: A Pilot Study
SO CURRENT ISSUES IN MOLECULAR BIOLOGY
LA English
DT Article
DE dietary oleic acid; n-6/n-3 HUFA; metabolism; cardiometabolic
   biomarkers; red blood cells
ID STEAROYL-COA DESATURASE; POLYUNSATURATED FATTY-ACIDS;
   LYSOPHOSPHATIDYLCHOLINE ACYLTRANSFERASE 3; ARACHIDONIC-ACID; ER STRESS;
   LIVER; ACTIVATION; INCREASES; PROTEIN; RISK
AB In this work, we studied the relationships between the most representative fatty acids (FAs) and their ratios in red blood cell (RBC) membranes and dietary fatty acids alongside several cardiometabolic risk factors. Twenty-six individuals were enrolled with a mean age of 50.4 +/- 12.7 years (16 males and 10 females). By bivariate analysis, dietary oleic acid (OA) correlated negatively with C20:4n-6 (AA) (p = 0.031) in RBCs. With multivariate regression analysis, dietary OA (p < 0.001) is an independent predictor and negatively associated with AA levels in RBCs, while the elongation of very-long-chain fatty acids 6 (ELOVL6) and stearoyl-CoA desaturase 16 (SCD16) activities (p < 0.05) was positively associated with AA levels in RBCs. The multivariate regression models also showed that dietary OA was an independent predictor and positively associated with C22:5n-3 (DPA) in RBCs. Furthermore, BMI positively correlated with SCD16, and both SCD16 and SCD18 were positively associated with triacylglycerols levels. In addition, SCD16 positively and significantly correlated with LDL-c and the LDL-c/HDL-c ratio and negatively correlated with the ApoA1/ApoB ratio, and SCD16 and ELOVL6 were significantly associated with HDL molecular subfractions. Therefore, our data underline that OA, SCD16 and ELOVL6 can interfere with n-3 and n-6 partition in biomembranes such as RBCs, suggesting an important molecular (patho)physiological regulatory mechanism role in controlling bioactive molecules' availability such as those involved in the immune-inflammatory response.
C1 [Bispo, Paulo] Inst Politecn Santarem, Dept Food Tecnhol Biotecnol & Nutr, Escola Super Agr, P-2001904 Santarem, Portugal.
   [Rodrigues, Pedro O.] Univ Nova Lisboa UNL, Fac Med Sci, NOVA Med Sch, Dept Biochem, P-1169056 Lisbon, Portugal.
   [Rodrigues, Pedro O.] Univ Nova Lisboa UNL, Fac Med Sci, NOVA Med Sch, CEDOC, P-1169056 Lisbon, Portugal.
   [Bandarra, Narcisa M.] IPMA, Dept Mar & Recursos Marinhos, Div Aquacultura Valorizacao & Biosprospecao, IP, P-1495165 Lisbon, Portugal.
   [Bandarra, Narcisa M.] CIIMAR, Ctr Interdisciplinar Invest Marinha & Ambiental, Terminal Cruzeiros Leixoes, P-4450208 Matosinhos, Portugal.
C3 Instituto Politecnico de Santarem; Universidade Nova de Lisboa;
   Universidade Nova de Lisboa; Instituto Portugues do Mar e da Atmosfera;
   Universidade do Porto
RP Bispo, P (corresponding author), Inst Politecn Santarem, Dept Food Tecnhol Biotecnol & Nutr, Escola Super Agr, P-2001904 Santarem, Portugal.
EM paulo.bispo@esa.ipsantarem.pt; prof.orlandorod@gmail.com;
   narcisa@ipma.pt
RI Bandarra, Narcisa/C-4780-2013
FU Fundaco para a Ciencia e a Tecnologia (FCT) [PTDC-SAU/OSM/2006/70560]
FX The present study was supported by Fundaco para a Ciencia e a Tecnologia
   (FCT) through the grant PTDC-SAU/OSM/2006/70560 (principal investigator:
   P.O.R.).
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NR 68
TC 0
Z9 0
U1 3
U2 3
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
SN 1467-3037
EI 1467-3045
J9 CURR ISSUES MOL BIOL
JI Curr. Issues Mol. Biol.
PD FEB
PY 2025
VL 47
IS 2
AR 81
DI 10.3390/cimb47020081
PG 15
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA Y2K3J
UT WOS:001430474100001
PM 39996802
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Zhang, Z
   Fu, XD
   Zhou, FZ
   Zhang, DC
   Xu, YQ
   Fan, ZH
   Wen, SM
   Shao, YT
   Yao, Z
   He, YM
AF Zhang, Zeng
   Fu, Xiaodong
   Zhou, Fengzhu
   Zhang, Duanchun
   Xu, Yanqiu
   Fan, Zhaohua
   Wen, Shimei
   Shao, Yanting
   Yao, Zheng
   He, Yanming
TI Huaju Xiaoji Formula Regulates ERS-lncMGC/miRNA to Enhance the Renal
   Function of Hypertensive Diabetic Mice with Nephropathy
SO JOURNAL OF DIABETES RESEARCH
LA English
DT Article
ID ENDOPLASMIC-RETICULUM-STRESS; CHINESE HERBAL MEDICINE; CHRONIC
   KIDNEY-DISEASE; VASCULAR ENDOTHELIAL DYSFUNCTION; UNFOLDED PROTEIN
   RESPONSE; OXIDATIVE-STRESS; TRANSCRIPTIONAL REGULATION; METABOLIC
   SYNDROME; MELLITUS; FIBROSIS
AB Background. Better therapeutic drugs are required for treating hypertensive diabetic nephropathy. In our previous study, the Huaju Xiaoji (HJXJ) formula promoted the renal function of patients with diabetes and hypertensive nephropathy. In this study, we investigated the therapeutic effect and regulation mechanism of HJXJ in hypertensive diabetic mice with nephropathy. Methods. We constructed a mouse hypertensive diabetic nephropathy (HDN) model by treating mice with streptozotocin (STZ) and nomega-nitro-L-arginine methyl ester (LNAME). We also constructed a human glomerular mesangial cell (HGMC) model that was induced by high doses of sugar (30 mmol/mL) and TGF beta 1 (5 ng/mL). Pathological changes were evaluated by hematoxylin and eosin (H&E) staining, periodic acid Schiff (PAS) staining, and Masson staining. The fibrosis-related molecules (TGF beta 1, fibronectin, laminin, COL I, COL IV, alpha-SMA, and p-smad2/3) were detected by enzyme-linked immunosorbent assay (ELISA). The mRNA levels and protein expression of endoplasmic reticulum stress, fibrosis molecules, and their downstream molecules were assessed using qPCR and Western blotting assays. Results. Administering HJXJ promoted the renal function of HDN mice. HJXJ reduced the expression of ER stress makers (CHOP and GRP78) and lncMGC, miR379, miR494, miR495, miR377, CUGBP2, CPEB4, EDEM3, and ATF3 in HDN mice and model HGMCs. The positive control drugs (dapagliflozin and valsartan) also showed similar effects after treatment with HJXJ. Additionally, in model HGMCs, the overexpression of CHOP or lncMGC decreased the effects of HJXJ-M on the level of fibrosis molecules and downstream target molecules. Conclusion. In this study, we showed that the HJXJ formula may regulate ERS-lncMGC/miRNA to enhance renal function in hypertensive diabetic mice with nephropathy. This study may act as a reference for further investigating whether combining HJXJ with other drugs can enhance its therapeutic effect. The findings of this study might provide new insights into the clinical treatment of hypertensive diabetic nephropathy with HJXJ.
C1 [Zhang, Zeng; Zhou, Fengzhu; Zhang, Duanchun; Xu, Yanqiu; Fan, Zhaohua; Wen, Shimei; Shao, Yanting; Yao, Zheng; He, Yanming] Shanghai Univ Tradit Chinese Med, Yueyang Hosp Integrated Tradit Chinese & Western M, Dept Endocrinol, Shanghai 200437, Peoples R China.
   [Fu, Xiaodong] Fudan Univ, Huashan Hosp, Dept Integrated Tradit Chinese & Western Med, Shanghai 200040, Peoples R China.
C3 Shanghai University of Traditional Chinese Medicine; Fudan University
RP Yao, Z; He, YM (corresponding author), Shanghai Univ Tradit Chinese Med, Yueyang Hosp Integrated Tradit Chinese & Western M, Dept Endocrinol, Shanghai 200437, Peoples R China.
EM zengzeng31@163.com; 13012838220@163.com; zhutunmu8628391491@163.com;
   zhang1998930@126.com; xuyanqiu1781@163.com; lanlanfanfan@sina.com;
   wsm2319@126.com; ytshao529@163.com; yaozheng8848@163.com;
   heyanming@shutcm.edu.cn
RI shao bin, li/HME-2779-2023
FU National Natural Science Foundation of China; Youth Project of National
   Natural Science Foundation of China [82004263];  [81973818]
FX This work was supported by the National Natural Science Foundation of
   China (Grant No.: 81973818) and Youth Project of National Natural
   Science Foundation of China (Grant No.: 82004263).
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NR 87
TC 4
Z9 4
U1 3
U2 9
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2314-6745
EI 2314-6753
J9 J DIABETES RES
JI J. Diabetes Res.
PD JAN 20
PY 2024
VL 2024
AR 6942156
DI 10.1155/2024/6942156
PG 19
WC Endocrinology & Metabolism; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Research & Experimental Medicine
GA FY0X5
UT WOS:001149306400002
PM 38282657
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Kochi, T
   Shimizu, M
   Sumi, T
   Kubota, M
   Shirakami, Y
   Tanaka, T
   Moriwaki, H
AF Kochi, Takahiro
   Shimizu, Masahito
   Sumi, Takafumi
   Kubota, Masaya
   Shirakami, Yohei
   Tanaka, Takuji
   Moriwaki, Hisataka
TI Inhibitory effects of astaxanthin on azoxymethane-induced colonic
   preneoplastic lesions in C57/BL/KsJ-db/db mice
SO BMC GASTROENTEROLOGY
LA English
DT Article
DE Astaxanthin; Chemoprevention; Preneoplastic lesions; Colon; Obesity;
   Mice
ID BASE-LINE CHARACTERISTICS; ABERRANT CRYPT FOCI; NF-KAPPA-B; METABOLIC
   SYNDROME; OXIDATIVE STRESS; BETA-CAROTENE; PREMALIGNANT LESIONS;
   COLORECTAL-CANCER; ALPHA-TOCOPHEROL; OBESE
AB Background: Obesity and related metabolic abnormalities, including excess oxidative stress and chronic inflammation, are associated with colorectal carcinogenesis. Astaxanthin, a xanthophyll carotenoid found in aquatic animals, is known to possess antioxidant, anti-inflammatory, and antineoplastic properties. The present study examined the effects of astaxanthin on the development of azoxymethane (AOM)-induced colonic premalignant lesions in C57BL/KsJ-db/db (db/db) obese mice.
   Method: Male db/db mice were administered 4 weekly subcutaneous injections of AOM (15 mg/kg body weight) from 5 weeks of age and subsequently, from 1 week after the last injection of AOM, were fed a diet containing 200 ppm astaxanthin throughout the experiment (8 weeks).
   Result: The development of colonic premalignant lesions, i.e., aberrant crypt foci and beta-catenin accumulated crypts, was significantly inhibited in mice treated with astaxanthin than in mice fed the basal diet. Astaxanthin administration markedly reduced urinary levels of 8-OHdG and serum levels of d-ROMs, which are oxidative stress markers, while increasing the expression of mRNA for the antioxidant enzymes GPx1, SOD1, and CAT in the colonic mucosa of AOM-treated db/db mice. The expression levels of IL-1 beta, IL-6, F4/80, CCL2, and CXCL2 mRNA in the colonic mucosa of AOM-treated mice were significantly decreased by astaxanthin. Dietary feeding with astaxanthin also resulted in a reduction in the numbers of NF-kappa B- and PCNA-positive cells that were increased by AOM exposure, in the colonic epithelium.
   Conclusion: These findings suggest that astaxanthin inhibits the development of colonic premalignant lesions in an obesity-related colorectal carcinogenesis model by reducing oxidative stress, attenuating chronic inflammation, and inhibiting NF-kappa B activation and cell proliferation in the colonic mucosa. Astaxanthin, therefore, may be a potential candidate as a chemoprevention agent against colorectal carcinogenesis in obese individuals.
C1 [Kochi, Takahiro; Shimizu, Masahito; Sumi, Takafumi; Kubota, Masaya; Shirakami, Yohei; Moriwaki, Hisataka] Gifu Univ, Grad Sch Med, Dept Gastroenterol Internal Med, Gifu 5011194, Japan.
   [Tanaka, Takuji] Gifu Univ, Grad Sch Med, Dept Tumor Pathol, Gifu 5011194, Japan.
C3 Gifu University; Gifu University
RP Shimizu, M (corresponding author), Gifu Univ, Grad Sch Med, Dept Gastroenterol Internal Med, 1-1 Yanagido, Gifu 5011194, Japan.
EM shimim-gif@umin.ac.jp
FU Ministry of Education, Science, Sports and Culture of Japan [22790638,
   25460988]; Ministry of Health, Labor and Welfare of Japan; Takeda
   Science Foundation; Grants-in-Aid for Scientific Research [22790638,
   25460988] Funding Source: KAKEN
FX This work was supported in part by Grants-in-Aid from the Ministry of
   Education, Science, Sports and Culture of Japan (No. 22790638 and No.
   25460988), Grant-in-Aid for the 3rd Term Comprehensive 10-Year Strategy
   for Cancer Control from the Ministry of Health, Labor and Welfare of
   Japan, and the Takeda Science Foundation.
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NR 54
TC 29
Z9 29
U1 1
U2 31
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-230X
J9 BMC GASTROENTEROL
JI BMC Gastroenterol.
PD DEC 17
PY 2014
VL 14
AR 212
DI 10.1186/s12876-014-0212-z
PG 10
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA AX2AG
UT WOS:000346744900001
PM 25515685
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Risérus, U
   Vessby, B
   Ärnlöv, J
   Basu, S
AF Risérus, U
   Vessby, B
   Ärnlöv, J
   Basu, S
TI Effects of cis-9,trans-11 conjugated linoleic acid
   supplementation on insulin sensitivity, lipid peroxidation, and
   proinflammatory markers in obese men
SO AMERICAN JOURNAL OF CLINICAL NUTRITION
LA English
DT Article
DE trans fatty acids; fatty acids; conjugated linoleic acid; dairy fat;
   diet; insulin resistance; abdominal obesity; inflammation; oxidative
   stress; lipid peroxidation
ID OXIDATIVE STRESS; METABOLIC SYNDROME; OXIDANT STRESS; RESISTANCE;
   HUMANS; ISOMER; INDEX; RADIOIMMUNOASSAY; F2-ALPHA; PROTEIN
AB Background: We recently showed that trans-10,cis-12 (t10,c12) conjugated linoleic acid (CLA) causes insulin resistance in obese men. However, metabolic effects of the c9,t11 CLA isomer are still unknown in obese men. Because c9,t11 CLA is the predominant CLA isomer in foods and is included in dietary weight-loss products, it is important to conduct randomized controlled studies that use c9,t11 CLA preparations.
   Objective: We investigated the effects of c9,t11 CLA supplementation on insulin sensitivity, body composition, and lipid peroxidation in a group at high risk for cardiovascular disease.
   Design: In a randomized, double-blind, placebo-controlled study, 25 abdominally obese men received 3 g c9,t11 CLA/d or placebo (olive oil). Before and after 3 mo of supplementation, we assessed insulin sensitivity (hyperinsulinemic euglycemic clamp), lipid metabolism. body composition, and urinary 8-iso-prostaglandin F-2alpha (a major F-2-isoprostane) and 15-keto-dihydro-prostaglandin F-2alpha, markers of in vivo oxidative stress and inflammation, respectively.
   Results: All subjects completed the study. Compared with placebo, c9,t11 CLA decreased insulin sensitivity by 15% (P < 0.05) and increased 8-iso-prostagiandin F-2alpha and 15-keto-dihydroprostaglandin F-2alpha excretion by 50% (P < 0.01) and 15% (P < 0.05), respectively. The decreased insulin sensitivity was independent of changes in serum lipids, glycemia, body mass index, and body fat but was abolished after adjustment for changes in 8-iso-prostaglandin F2, concentrations. There were no differences between groups in body composition.
   Conclusions: A CLA preparation containing the purified c9,t1 I CLA isomer increased insulin resistance and lipid peroxidation compared with placebo in obese men. Because c9,t1 I CLA occurs in commercial supplements as well as in the diet, the present results should be confirmed in larger studies that also include women.
C1 Uppsala Univ, Dept Publ Hlth & Caring Sci Geriatr, Clin Nutr Res Unit, S-75125 Uppsala, Sweden.
C3 Uppsala University
RP Uppsala Univ, Dept Publ Hlth & Caring Sci Geriatr, Clin Nutr Res Unit, Box 609, S-75125 Uppsala, Sweden.
EM ulf.nserus@pubcare.uu.se
RI ärnlöv, Johan/AAF-2746-2019
OI Arnlov, Johan/0000-0002-6933-4637
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NR 33
TC 199
Z9 216
U1 0
U2 13
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0002-9165
EI 1938-3207
J9 AM J CLIN NUTR
JI Am. J. Clin. Nutr.
PD AUG
PY 2004
VL 80
IS 2
BP 279
EP 283
PG 5
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 841ET
UT WOS:000222912800007
PM 15277146
DA 2025-06-11
ER

PT J
AU Hajek, T
   McIntyre, R
   Alda, M
AF Hajek, Tomas
   McIntyre, Roger
   Alda, Martin
TI Bipolar disorders, type 2 diabetes mellitus, and the brain
SO CURRENT OPINION IN PSYCHIATRY
LA English
DT Review
DE bipolar disorders; hippocampus; insulin resistance; lithium;
   pioglitazone; type 2 diabetes mellitus
ID MAJOR DEPRESSIVE DISORDER; PIOGLITAZONE ADJUNCTIVE THERAPY; BODY-MASS
   INDEX; INSULIN-RESISTANCE; COGNITIVE DECLINE; DOUBLE-BLIND;
   METAANALYSIS; PROGRESSION; VOLUMES; DISEASE
AB Purpose of reviewType 2 diabetes mellitus (T2DM) negatively affects brain structure and function. Meta-analytical data show that relative to age and sex matched non-psychiatric controls, patients with bipolar disorders have double the risk of T2DM. We review the evidence for association between T2DM and adverse clinical and brain imaging changes in bipolar disorders and summarize studies investigating effects of diabetes treatment on psychiatric and brain outcomes.Recent findingsParticipants with bipolar disorders and T2DM or insulin resistance demonstrate greater morbidity, chronicity and disability, and lower treatment response to Li. Bipolar disorders complicated by insulin resistance/T2DM are associated with smaller hippocampal and cortical gray matter volumes and lower prefrontal N-acetyl aspartate (neuronal marker). Treatment of T2DM yields preservation of brain gray matter and insulin sensitizers, such as pioglitazone, improve symptoms of depression in unipolar or bipolar disorders.SummaryT2DM or insulin resistance frequently cooccur with bipolar disorders and are associated with negative psychiatric clinical outcomes and compromised brain health. This is clinically concerning, as patients with bipolar disorders have an increased risk of metabolic syndrome and yet often receive suboptimal medical care. At the same time treatment of T2DM and insulin resistance has positive effects on psychiatric and brain outcomes. These findings create a rich agenda for future research, which could enhance psychiatric pharmacopeia and directly impact patient care.
C1 [Hajek, Tomas; Alda, Martin] Dalhousie Univ, Dept Psychiat, Halifax, NS B3H 2E2, Canada.
   [Hajek, Tomas; Alda, Martin] NIMH, Klecany, Czech Republic.
   [McIntyre, Roger] Univ Toronto, Dept Psychiat, Toronto, ON, Canada.
C3 Dalhousie University; National Institute of Mental Health - Czech
   Republic; University of Toronto
RP Hajek, T (corresponding author), Dalhousie Univ, Dept Psychiat, QEII HSC, AJ Lane Bldg,Room 3093,5909 Vet Mem Lane, Halifax, NS B3H 2E2, Canada.
EM tomas.hajek@dal.ca
RI Alda, Martin/F-5812-2010; McIntyre, Roger/AAU-1000-2020; Hajek,
   Tomas/U-9185-2018
OI Hajek, Tomas/0000-0003-0281-8458
FU NARSAD Independent Investigator Award; Canadian Institutes of Health
   Research grant [341717]; Johnson Johnson; AstraZeneca; Eli-Lilly;
   Purdue; Shire; Allergan; Lundbeck; Pfizer
FX This work was supported by NARSAD Independent Investigator Award to Dr
   Hajek and by funding from the Canadian Institutes of Health Research
   grant (341717).Dr McIntyre is a consultant/ speaker/received research
   grant support from Johnson & Johnson, AstraZeneca, Eli-Lilly, Purdue,
   Shire, Allergan, Lundbeck, Pfizer.
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NR 40
TC 26
Z9 26
U1 2
U2 11
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0951-7367
EI 1473-6578
J9 CURR OPIN PSYCHIATR
JI Curr. Opin. Psychiatr.
PD JAN
PY 2016
VL 29
IS 1
BP 1
EP 6
DI 10.1097/YCO.0000000000000215
PG 6
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA DD0ZF
UT WOS:000369649700001
PM 26575297
DA 2025-06-11
ER

PT J
AU Korman, NJ
   Zhao, Y
   Li, YF
   Liao, ML
   Tran, MH
AF Korman, Neil J.
   Zhao, Yang
   Li, Yunfeng
   Liao, Minlei
   Tran, Mary Helen
TI Clinical symptoms and self-reported disease severity among patients with
   psoriasis - Implications for psoriasis management
SO JOURNAL OF DERMATOLOGICAL TREATMENT
LA English
DT Article
DE Flare-ups; itching; pain; psoriasis; psoriasis symptoms
ID QUALITY-OF-LIFE; POPULATION-BASED-COHORT; METABOLIC SYNDROME;
   ADMINISTERED PSORIASIS; INCREASED RISK; PREVALENCE; PRURITUS; BURDEN;
   IMPACT; INDEX
AB Background: Pain, itching, burning and irritation are common symptoms of psoriasis but have not been well characterized by overall psoriasis severity. Methods: Using 2012 syndicated psoriasis patient survey data, 1050 subjects were classified into mild (n = 610) and moderate-to-severe (n = 440) psoriasis severity groups based on self-reporting. Demographics, comorbid medical conditions and patient-reported key symptoms (i. e. flare-up frequency, psoriasis-related pain, itching, burning, hurting, irritation) were compared between groups. Multiple regressions were employed to examine the impact of overall psoriasis severity on each key symptom, controlling for demographics and comorbidities. Results: Mild patients were older; more than 20% in both groups had joint pain and depression. Over 35 and 68% of the moderate-to-severe patients reported severe pain between or during flare-ups, respectively, and over 79% reported frequent bothersome itching. Controlling for between-group differences, moderate-to-severe patients had worse pain, were more likely to have continual flare-ups (odds ratio = 3.0) and flare-ups more than once monthly (odds ratio = 3.0), and reported more bothersome symptoms than patients with mild disease (all p<0.05). Conclusion: The presence and level of particular symptoms increase with self-reported disease severity in patients with psoriasis. Careful investigation of symptoms in tandem with clinical observation is important for effective psoriasis management.
C1 [Korman, Neil J.] Univ Hosp Case Med Ctr, Dept Dermatol, 11100 Euclid Ave, Cleveland, OH 44106 USA.
   [Zhao, Yang; Li, Yunfeng; Tran, Mary Helen] Novartis Pharmaceut, E Hanover, NJ USA.
   [Liao, Minlei] KMK Consulting Inc, Florham Pk, NJ USA.
C3 University System of Ohio; Case Western Reserve University; Case Western
   Reserve University Hospital; Novartis; Novartis USA
RP Korman, NJ (corresponding author), Univ Hosp Case Med Ctr, Dept Dermatol, 11100 Euclid Ave, Cleveland, OH 44106 USA.
EM Neil.Korman@UHhospitals.org
FU Abbvie; Amgen; Celgene; Eli Lily; Genentech; Janssen; Pfizer; Novartis
   Pharmaceuticals Corporation; Novartis Pharmaceuticals Corporation (East
   Hanover, NJ, USA)
FX N.J.K. received grant funding for his participation in this project; has
   been an investigator for Abbvie, Amgen, Celgene, Eli Lily, Genentech,
   Janssen and Pfizer; served on advisory boards for Amgen, Astellas,
   Baxter, Celgene, Eli Lily, Genentech, Janssen, Novartis and Pfizer; has
   been a consultant for Apopharma and Astellas; and served as a speaker
   for Abbvie, Amgen, Astellas, Genentech and Janssen. Y.Z. and Y.L. are
   salaried employees of Novartis Pharmaceuticals Corporation. M.L. is a
   paid consultant to Novartis Pharmaceuticals Corporation. M.H.T. was a
   salaried employee of Novartis Pharmaceuticals Corporation at the time
   the study was conducted.Novartis Pharmaceuticals Corporation (East
   Hanover, NJ, USA) provided funding for the study and for its
   publication.
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NR 47
TC 14
Z9 16
U1 0
U2 4
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0954-6634
EI 1471-1753
J9 J DERMATOL TREAT
JI J. Dermatol. Treat.
PY 2015
VL 26
IS 6
BP 514
EP 519
DI 10.3109/09546634.2015.1034074
PG 6
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA DD5JP
UT WOS:000369960000005
PM 25886083
DA 2025-06-11
ER

PT J
AU Martinez, JA
   Palacios, S
   Chavida, F
   Pérez, M
AF Martinez, J. A.
   Palacios, S.
   Chavida, F.
   Perez, M.
TI Urban-rural differences in Spanish menopausal women
SO RURAL AND REMOTE HEALTH
LA English
DT Article
DE cardiovascular disease; menopause; osteoporosis; risk factors; Spain;
   urban-rural differences; women's health
ID METABOLIC SYNDROME; RISK-FACTORS; HOT FLASHES; OSTEOPOROSIS; MANAGEMENT;
   SYMPTOMS; EXPERIENCE; TRANSITION; FRACTURE; THERAPY
AB Introduction: Most women spend one-third to half of their lifespan in the postmenopausal phase. As menopause involves biological and psychosocial changes that may significantly impair quality of life, the objectives of this study were to: (1) evaluate the prevalence of risk factors for osteoporosis and cardiovascular disease and the prevalence and severity of the appearance of menopausal symptoms among rural and urban Spanish menopausal women; (2) identify the main factors responsible for severity of symptoms; and (3) detect symptom differences between rural and urban women.
   Methods: This cross-sectional descriptive study included 10 514 random-sampled women aged 45-65 years from Spain. Sociodemographic information, medical history and lifestyle data were assessed by survey. The Kupperman scale was used to assess severity of menopausal symptoms.
   Results: Urban women had a higher prevalence of cardiovascular and osteoporosis risk factors than rural women, although this was not statistically significant. There was a greater frequency of menopausal symptoms in urban women although rural women experienced more hot flushes (p<0.05), depression, joint pain and tingling. In rural women menopausal symptoms were less severe (p<0.01).
   Conclusions: A high prevalence of risk factors for osteoporosis, and cardiovascular disease in particular, was observed. There were statistically significant differences between urban and rural women for some cardiovascular risk factors, frequency of hot flushes and severity of menopausal symptoms.
C1 [Martinez, J. A.] Primary Hlth Ctr Guadalajara Sur, Guadalajara, Spain.
   [Palacios, S.] Palacios Inst Womens Hlth & Med, Madrid, Spain.
   [Chavida, F.] Primary Hlth Ctr Cervantes, Guadalajara, Spain.
   [Perez, M.] Almirall Pharmaceut, Dept Med, Barcelona, Spain.
C3 Almirall
RP Martinez, JA (corresponding author), Primary Hlth Ctr Guadalajara Sur, Guadalajara, Spain.
RI PALACIOS, SANTIAGO/H-1818-2012
OI Palacios, Santiago/0000-0003-2229-1200
FU Almirall Pharmaceuticals; Sanofi-Aventis
FX The authors express sincere gratitude to all investigators who actively
   participated in this study. Although they are too many to list, without
   their dedication and quality of work this publication would not have
   been possible. Also thanked are Almirall Pharmaceuticals and
   Sanofi-Aventis for their support, which was essential in order to
   complete this study.
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NR 37
TC 12
Z9 14
U1 0
U2 3
PU AUSTRALIAN RURAL HEALTH EDUC NETWORK
PI DEAKIN WEST
PA PO BOX 242, DEAKIN WEST, ACT 2600, AUSTRALIA
SN 1445-6354
J9 RURAL REMOTE HEALTH
JI Rural Remote Health
PD APR-JUN
PY 2013
VL 13
IS 2
AR 1865
PG 12
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA 190UF
UT WOS:000322365600015
PM 23634693
DA 2025-06-11
ER

PT J
AU Ferrara, L
   Joksimovic, M
   D'Angelo, S
AF Ferrara, Luigi
   Joksimovic, Marko
   D'Angelo, Stefania
TI Could Polyphenolic Food Intake Help in the Control of Type 2 Diabetes? A
   Narrative Review of the Last Evidence
SO CURRENT NUTRITION & FOOD SCIENCE
LA English
DT Review
DE Type 2 diabetes; diet; polyphenols; polyphenolic food; nutrition; human;
   prevention
ID VIRGIN OLIVE OIL; DOUBLE-BLIND; CARDIOVASCULAR-DISEASE; INFLAMMATORY
   MARKERS; MEDITERRANEAN DIET; INSULIN-RESISTANCE; ENDOTHELIAL FUNCTION;
   GLYCEMIC CONTROL; PROCESSED MEAT; RISK-FACTORS
AB Background: Diabetes is one of the most serious global public health concerns, imposing a significant burden on public health and socio-economic development, with type 2 diabetes accounting for 90 percent of individuals with the disease (T2D).
   Introduction: Beyond the hereditary factor, there are several risk factors associated with the development of this syndrome; the lifestyle plays an increasingly predominant role in the development of the metabolic complications related to T2D and a significant role in the onset of this syndrome is played by an unbalanced diet. Polyphenolic food is a plant-based food, including vegetables, fruits, whole grains, tea, coffee, and nuts. In recent years, there has been growing evidence that polyphenols, due to their biological properties, may be used as nutraceuticals and supplementary treatments for various aspects of T2D. Polyphenols may influence glycemia and T2D through hypoglycemic properties, such as reduced insulin resistance, reduced fasting blood glucose, and glycosylated hemoglobin value. Based on several in vitro, animal models, and some human studies, it has been detected that polyphenol-rich products modulate carbohydrate and lipid metabolism, attenuate hyperglycemia, dyslipidemia, and insulin resistance, improve adipose tissue metabolism, and alleviate oxidative stress and stress-sensitive signaling pathways and inflammatory processes.
   Methods: This manuscript summarizes human clinical trials conducted within the last 5 years linking dietary polyphenols to T2D, with a focus on polyphenolic foods found in the Mediterranean diet.
   Results: Intaking polyphenols and their food sources have demonstrated beneficial effects on insulin resistance and other cardiometabolic risk factors. Prospective studies have shown inverse associations between polyphenol intake and T2D. The Mediterranean diet and its key components, olive oil, nuts, and red wine, have been inversely associated with insulin resistance and T2D.
   Conclusion: In conclusion, the intake of polyphenols may be beneficial for both insulin resistance and T2D risk. However, other human clinical studies are needed to evaluate the suitable dose and duration of supplementation with polyphenolic food in T2D patients.
C1 [Ferrara, Luigi; D'Angelo, Stefania] Univ Naples Parthenope, Dept Motor Sci & Wellness, Naples, Italy.
   [Joksimovic, Marko] Inst Sports & Sports Med, Podgorica, Montenegro.
C3 Parthenope University Naples
RP D'Angelo, S (corresponding author), Univ Naples Parthenope, Dept Motor Sci & Wellness, Naples, Italy.
EM stefania.dangelo@uniparthenope.it
RI Joksimovic, Marko/AAU-3782-2020; D'Angelo, Stefania/AAI-2594-2019
OI Ferrara, Luigi/0000-0002-4857-2118; Joksimovic,
   Marko/0000-0003-4232-5033; D'Angelo, Stefania/0000-0001-7585-5052
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NR 129
TC 3
Z9 3
U1 0
U2 6
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1573-4013
EI 2212-3881
J9 CURR NUTR FOOD SCI
JI Curr. Nutr. Food Sci.
PY 2022
VL 18
IS 9
BP 785
EP 798
DI 10.2174/1573401318666220317140717
PG 14
WC Nutrition & Dietetics
WE Emerging Sources Citation Index (ESCI)
SC Nutrition & Dietetics
GA 4M4TE
UT WOS:000853315300004
DA 2025-06-11
ER

PT J
AU Lemke, MK
   Hege, A
   Perko, M
   Sönmez, S
   Apostolopoulos, Y
AF Lemke, M. K.
   Hege, A.
   Perko, M.
   Sonmez, S.
   Apostolopoulos, Y.
TI Work patterns, sleeping hours and excess weight in commercial drivers
SO OCCUPATIONAL MEDICINE-OXFORD
LA English
DT Article
DE Central obesity; commercial drivers; shift work; total body obesity;
   work hours
ID QUALITY-OF-LIFE; RISK-FACTORS; OBESITY; DURATION; HEALTH; TRUCK;
   ASSOCIATION; QUESTIONNAIRE; STRESS; IMPACT
AB Background Work and sleep patterns for commercial motor vehicle (CMV) drivers often include long working hours, shift work and diminished sleep duration and quality, which have been linked to overweight, obesity and other problems. Aims To explore possible connections between work, sleep and obesity among CMV drivers.
   Methods Survey and anthropometric data were collected from male long-haul CMV drivers in central North Carolina, USA, over a period of 6 months. Drivers' body mass index (BMI) was used as a measure of total body obesity and sagittal abdominal diameter (SAD) as a measure of central adiposity.
   Results Among the 260 study subjects, mean BMI was 33.1 (64% were obese or morbidly obese) and mean SAD was 32.3 cm, classifying 89% of drivers as being at high or very high cardiometabolic risk. About 83% of drivers worked an irregular daily schedule, 64% worked irregular total daily hours, 32% worked irregular days of the week and 46% reported getting <7 h of sleep during work nights. Significant predictors of BMI included the number of hours worked daily (P < 0.05) and the age (P < 0.01) of the driver, while age was also a significant predictor for SAD (P < 0.05). Significant predictors of sleep quality included the extent of shift work (P < 0.05) and sleep duration (P < 0.001).
   Conclusions Work and sleep configurations appear to affect the weight status of CMV drivers. Shift work and sleep duration are both associated with the weight status of CMV drivers, and both appear to function as indicators of their sleep quality.
C1 [Lemke, M. K.; Apostolopoulos, Y.] Texas A&M Univ, Dept Hlth & Kinesiol, 4243 TAMU, College Stn, TX 77843 USA.
   [Hege, A.; Perko, M.] Univ N Carolina, Dept Publ Hlth Educ, Greensboro, NC 27412 USA.
   [Sonmez, S.] Univ Cent Florida, Dept Tourism Events & Attract, Orlando, FL 32819 USA.
C3 Texas A&M University System; Texas A&M University College Station;
   University of North Carolina; University of North Carolina Greensboro;
   State University System of Florida; University of Central Florida
RP Lemke, MK (corresponding author), Texas A&M Univ, Dept Hlth & Kinesiol, 4243 TAMU, College Stn, TX 77843 USA.
EM michael.lemke@hlkn.tamu.edu
RI Hege, Adam/AGF-0054-2022
OI Hege, Adam/0000-0003-2515-6848
FU University of North Carolina Greensboro's (UNCG) Office of Research and
   Economic Development; UNCG's School of Health and Human Sciences; Bryan
   School of Business and Economics; Department of Public Health Education;
   Department of Kinesiology
FX University of North Carolina Greensboro's (UNCG) Office of Research and
   Economic Development (to Y.A.); UNCG's School of Health and Human
   Sciences; Bryan School of Business and Economics; Department of Public
   Health Education; Department of Kinesiology.
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NR 30
TC 29
Z9 37
U1 0
U2 16
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0962-7480
EI 1471-8405
J9 OCCUP MED-OXFORD
JI Occup. Med.-Oxf.
PD DEC
PY 2015
VL 65
IS 9
BP 725
EP 731
DI 10.1093/occmed/kqv080
PG 7
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA DJ4OQ
UT WOS:000374186400010
PM 26116265
OA Bronze
DA 2025-06-11
ER

PT J
AU Bilbo, SD
   Tsang, V
AF Bilbo, Staci D.
   Tsang, Verne
TI Enduring consequences of maternal obesity for brain inflammation and
   behavior of offspring
SO FASEB JOURNAL
LA English
DT Article
DE cytokines; hippocampus; cognition; microglia; perinatal programming
ID DIET-INDUCED OBESITY; FATTY-ACIDS; INSULIN-RESISTANCE; METABOLIC
   SYNDROME; DUAL ROLE; INTERLEUKIN-1; TRANS; CONSUMPTION; RESTRICTION;
   MICROGLIA
AB Obesity is well characterized as a systemic inflammatory condition, and is also associated with cognitive disruption, suggesting a link between the two. We assessed whether peripheral inflammation in maternal obesity may be transferred to the offspring brain, in particular, the hippocampus, and thereby result in cognitive dysfunction. Rat dams were fed a high-saturated-fat diet (SFD), a high-trans-fat diet (TFD), or a low-fat diet (LFD) for 4 wk prior to mating, and remained on the diet throughout pregnancy and lactation. SFD/TFD exposure significantly increased body weight in both dams and pups compared to controls. Microglial activation markers were increased in the hippocampus of SFD/TFD pups at birth. At weaning and in adulthood, proinflammatory cytokine expression was strikingly increased in the periphery and hippocampus following a bacterial challenge [lipo-polysaccharide (LPS)] in the SFD/TFD groups compared to controls. Microglial activation within the hippocampus was also increased basally in SFD rats, suggesting a chronic priming of the cells. Finally, there were marked changes in anxiety and spatial learning in SFD/TFD groups. These effects were all observed in adulthood, even after the pups were placed on standard chow at weaning, suggesting these outcomes were programmed early in life.-Bilbo, S. D., Tsang, V. Enduring consequences of maternal obesity for brain inflammation and behavior of offspring. FASEB J. 24, 2104-2115 (2010). www.fasebj.org
C1 [Bilbo, Staci D.; Tsang, Verne] Duke Univ, Dept Psychol & Neurosci, Durham, NC 27708 USA.
C3 Duke University
RP Bilbo, SD (corresponding author), Duke Univ, Dept Psychol & Neurosci, 572 Res Dr,Box 91050,3016 GSRB 2, Durham, NC 27708 USA.
EM staci.bilbo@duke.edu
RI Bilbo, Staci/L-5076-2016
OI Bilbo, Staci/0000-0001-6736-7841; Bilbo, Staci/0000-0001-7395-5033
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NR 55
TC 403
Z9 450
U1 2
U2 50
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
EI 1530-6860
J9 FASEB J
JI Faseb J.
PD JUN
PY 2010
VL 24
IS 6
BP 2104
EP 2115
DI 10.1096/fj.09-144014
PG 12
WC Biochemistry & Molecular Biology; Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 603HR
UT WOS:000278200000043
PM 20124437
DA 2025-06-11
ER

PT J
AU Ferraz, VD
   Pereira, JPD
   Ramiro, CPSP
   Arcoverde, GMPF
   Rodrigues, IG
   Chagas, CL
   de Queiroz, JRA
   de Lemos, MCC
   Diniz, AD
   de Arruda, IKG
AF Ferraz, Victoria Domingues
   da Costa Pereira, Jarson Pedro
   Pinho Ramiro, Claudia Porto Sabino
   Floro Arcoverde, Gabriela Maria Pereira
   Rodrigues, Isa Galvao
   Chagas, Camila Lima
   de Queiroz, Jose Reginaldo Alves
   de Lemos, Maria Conceicao Chaves
   da Silva Diniz, Alcides
   de Arruda, Ilma Kruze Grande
TI Is phase angle associated with visceral adiposity and cardiometabolic
   risk in cardiology outpatients?
SO EUROPEAN JOURNAL OF CLINICAL NUTRITION
LA English
DT Article
ID BIOELECTRICAL-IMPEDANCE ANALYSIS
AB Background/objectives: Phase angle (PhA) serves as a prognostic marker in various clinical scenarios, reflecting oxidative stress and cellular damage. Despite its clinical relevance, its connection with adiposity and cardiovascular risk markers remains underexplored. Hence, our study sought to investigate the relationship between PhA and metabolic, adiposity, and cardiovascular risk parameters among outpatients with cardiology diagnosis. Subjects/methods: Adults aged between 26 and 59 years, under the care of a cardiology unit, were included. Ultrasound imaging was used to assess visceral adipose tissue (VAT). Single-frequency bioelectrical impedance analysis (BIA) [50 kHz] was employed to calculate PhA, from BIA's resistance and reactance measurements. Muscle strength, body mass index, waist circumference, and waist-to-height ratio were also evaluated. Framingham's risk score was calculated to estimate the cardiovascular risk events. Metabolic blood samples' results were obtained from medical records. Results: One hundred and five participants were included in our study. Low PhA was observed in 29.5% of our sample. Higher PhA values were independently and inversely associated with both higher VAT and cardiovascular risk (adjusted OR: 0.79 [95% CI 0.69;0.91], OR: 0.74 [95% CI 0.60;0.89], respectively). Lower PhA values (<= 5.59) were goodly associated with high VAT (AUC: 0.82 p < 0.001). Lower PhA values (<= 5.06) were fairly associated with higher cardiovascular risk (AUC: 0.70 p = 0.003). Conclusion:Our study provides evidence that PhA is independently and inversely associated with elevated VAT and cardiovascular risk. These findings underscore the potential of PhA as a valuable complementary marker in assessing cardiometabolic health.
C1 [Ferraz, Victoria Domingues; da Costa Pereira, Jarson Pedro; Floro Arcoverde, Gabriela Maria Pereira; de Lemos, Maria Conceicao Chaves; da Silva Diniz, Alcides; de Arruda, Ilma Kruze Grande] Univ Fed Pernambuco, Dept Nutr, Prof Moraes Rego Ave,1235 Cidade Univ, BR-50670901 Recife, PE, Brazil.
   [Pinho Ramiro, Claudia Porto Sabino; Floro Arcoverde, Gabriela Maria Pereira; Rodrigues, Isa Galvao; Chagas, Camila Lima] Univ Pernambuco, Emergency Cardiol Unit, R Palmares,N-N Santo Amaro, BR-74970240 Recife, PE, Brazil.
   [de Queiroz, Jose Reginaldo Alves] Univ Fed Pernambuco, Med Sci Ctr, Prof Moraes Rego Ave,1235 Cidade Univ, BR-50670901 Recife, PE, Brazil.
C3 Universidade Federal de Pernambuco; Universidade de Pernambuco (UPE);
   Universidade Federal de Pernambuco
RP Pereira, JPD (corresponding author), Univ Fed Pernambuco, Dept Nutr, Prof Moraes Rego Ave,1235 Cidade Univ, BR-50670901 Recife, PE, Brazil.
EM jarsoncostap@gmail.com
RI Diniz, Alcides/LVS-6640-2024; da Costa Pereira, Jarson
   Pedro/HTO-6450-2023
OI da Costa Pereira, Jarson Pedro/0000-0001-5412-6467; Ferraz,
   Victoria/0000-0002-8061-7582; lima chagas, camila/0009-0009-7340-3955;
   Arcoverde, Gabriela/0000-0001-8749-029X; Rodrigues,
   Isa/0000-0002-6650-8558
FU Coordenao de Aperfeioamento de Pessoal de Nvel Superior (Brazilian
   Federal Agency for the Support and Evaluation of Graduate Education)
FX No Statement Available
CR [Anonymous], 2008, Int J Body Compos Res
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NR 34
TC 2
Z9 2
U1 1
U2 2
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0954-3007
EI 1476-5640
J9 EUR J CLIN NUTR
JI Eur. J. Clin. Nutr.
PD JUN
PY 2024
VL 78
IS 6
BP 527
EP 533
DI 10.1038/s41430-024-01435-7
EA MAR 2024
PG 7
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA UN5N5
UT WOS:001188837600001
PM 38514829
DA 2025-06-11
ER

PT J
AU Kim, J
   Yoon, DW
   Myoung, S
   Lee, SK
   Shin, C
AF Kim, Jinkwan
   Yoon, Dae Wui
   Myoung, Sungmin
   Lee, Seung Ku
   Shin, Chol
TI Coexistence of Moderate-to-Severe Obstructive Sleep Apnea and
   Inflammation Accelerates the Risk of Progression of Arterial Stiffness:
   A Prospective 6-Year Study
SO LIFE-BASEL
LA English
DT Article
DE obstructive sleep apnea; inflammation; high sensitivity C-reactive
   protein; arterial stiffness; pulse wave velocity; cardiovascular disease
ID C-REACTIVE PROTEIN; PULSE-WAVE VELOCITY; ALL-CAUSE MORTALITY;
   CARDIOVASCULAR-DISEASE; OXIDATIVE STRESS; ALPHA THERAPY; CHILDREN;
   ASSOCIATION; EVENTS; HEART
AB Both obstructive sleep apnea (OSA) and inflammation have now been recognized as imposing substantial cardiometabolic risk. However, no prospective study has reported whether the coexistence of OSA and inflammation exacerbates the progressive arterial stiffening. Thus, the purpose of this study is to examine whether these conditions increase the risk of the progression of arterial stiffening. A total of 1945 participants were randomly selected for the study. Subjects with elevated inflammation were divided by high-sensitivity C-reactive protein (hsCRP) levels. A polysomnography and brachial-ankle pulse wave velocity (baPWV) were performed. The elevation of the baPWV was defined as the levels in the highest quartile of the baPWV. The percentage of the elevated baPWV and the change in the baPWV (Delta baPWV) were higher in individuals with OSA and higher hsCRP levels. After adjusting for confounders, the participants with OSA and inflammation in the groups not treated with antihypertensive medication had a higher risk of an elevated Delta baPWV in contrast to those with neither variable. Particularly, the alteration in the baPWV differed significantly based on the existence of moderate-to-severe OSA and inflammation at the 6-year follow-up. In combination, these conditions are associated with an accelerated risk of a future burden of the progression of the arterial stiffness, suggesting a potential important role in the increased risk of CVD.
C1 [Kim, Jinkwan; Yoon, Dae Wui] Jungwon Univ, Coll Hlth Sci, Dept Biomed Lab Sci, Geo San, South Korea.
   [Myoung, Sungmin] Jungwon Univ, Coll Hlth Sci, Dept Med Informat & Adm, Geo San, South Korea.
   [Lee, Seung Ku; Shin, Chol] Korea Univ, Ansan Hosp, Inst Human Genom Study, Ansan 15355, South Korea.
   [Shin, Chol] Korea Univ, Coll Med, Dept Pulm Sleep & Crit Care Med, Disorder Ctr, Ansan 15355, South Korea.
C3 Jungwon University; Jungwon University; Korea University; Korea
   University Medicine (KU Medicine); Korea University; Korea University
   Medicine (KU Medicine)
RP Kim, J (corresponding author), Jungwon Univ, Coll Hlth Sci, Dept Biomed Lab Sci, Geo San, South Korea.; Shin, C (corresponding author), Korea Univ, Ansan Hosp, Inst Human Genom Study, Ansan 15355, South Korea.; Shin, C (corresponding author), Korea Univ, Coll Med, Dept Pulm Sleep & Crit Care Med, Disorder Ctr, Ansan 15355, South Korea.
EM jkkim@jwu.ac.kr; chol-shin@korea.ac.kr
RI lee, seungku/GSN-5012-2022; Kim, Jinyoung/LFS-2554-2024
OI Kim, Jinkwan/0000-0002-7123-1354; shin, chol/0000-0002-2928-8576
FU Korea Centers for Disease Control and Prevention;  [2007-E71001-00]; 
   [2008-E71001-00];  [2009-E71002-00];  [2010-E71001-00]; 
   [2011-E71004-00];  [2012-E71005-00];  [2013-E71005-00]; 
   [2014-E71003-00]
FX This research was supported by a fund (Grants 2007-E71001-00,
   2008-E71001-00, 2009-E71002-00, 2010-E71001-00, 2011-E71004-00,
   2012-E71005-00, 2013-E71005-00, and 2014-E71003-00) from the Korea
   Centers for Disease Control and Prevention.
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NR 60
TC 1
Z9 1
U1 0
U2 0
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2075-1729
J9 LIFE-BASEL
JI Life-Basel
PD NOV
PY 2022
VL 12
IS 11
AR 1823
DI 10.3390/life12111823
PG 14
WC Biology; Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics; Microbiology
GA 6W2UT
UT WOS:000895588600001
PM 36362978
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Fazzini, L
   Hubers, SA
   Cao, JJ
   Scott, CG
   McCully, RB
   Castrichini, M
   Figueiral, M
   Mohananey, A
   Wang, L
   Gulati, R
   Montisci, R
   Pellikka, PA
   Pereira, NL
AF Fazzini, Luca
   Hubers, Scott A.
   Cao, Jenny J.
   Scott, Christopher G.
   McCully, Robert B.
   Castrichini, Matteo
   Figueiral, Marta
   Mohananey, Akanksha
   Wang, Li
   Gulati, Rajiv
   Montisci, Roberta
   Pellikka, Patricia A.
   Pereira, Naveen L.
TI Exercise-Induced Reduction in Left Ventricular Ejection Fraction in the
   Absence of Coronary Artery Disease: Clinical Characteristics and
   Outcomes
SO JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY
LA English
DT Article
DE Heart failure; Heart failure with preserved ejection fraction;
   Echocardiography; Stress echocardiography
ID HEART-FAILURE; BLOOD-PRESSURE; SYNDROME-X; MYOCARDIAL DYSFUNCTION;
   STRESS ECHOCARDIOGRAMS; PATHOPHYSIOLOGY; ABNORMALITIES; PERFUSION; FLOW;
   SEX
AB Background: During exercise stress echocardiography (ESE), there are patients with normal left ventricular ejection fraction (LVEF) who paradoxically develop reduced LVEF during exercise despite absence of coronary artery disease (CAD) and a significant hypertensive response. This study sought to describe the clinical features and outcomes of this population. Methods: Among ESEs performed between 2003 and 2022, patients without CAD by angiogram within 90 days of ESE and resting LVEF >= 50% with a >= 5% LVEF decrease during ESE were included. Outcomes assessed were all-cause mortality, heart failure (HF) hospitalization, and atrial fibrillation (AF). Kaplan-Meier and Cox regression methods were used to analyze time-to-event outcomes. Results: Among 213,643 ESE, 134 patients met the eligibility criteria. The mean age of the population was 66 +/- 10 years, 76% were women, and 16% had AF at baseline. Mean LVEF was 58% +/- 4% at rest and 43% +/- 4% at peak stress. Stress ECG met the criteria for ischemia in 14% of these patients. The 10-year estimated incidence of HF hospitalization was 17.6% (95% CI, 9.0%-26.2%). Among the subgroup without AF at baseline, the 10-year estimated incidence of developing AF was 23.4% (95% CI, 13.4%-33.4%). The 10-year estimated incidence of all-cause mortality was 12.9% (95% CI, 5.5%-20.3%), with 89% of deaths occurring due to noncardiovascular causes. Conclusion: Patients with exercise-induced reduction in LVEF in the absence of obstructive CAD have a high incidence of HF hospitalizations and AF. The underlying pathophysiology of this disease process needs to be further investigated. (J Am Soc Echocardiogr 2025;38:421-30.)
C1 [Fazzini, Luca; Cao, Jenny J.; McCully, Robert B.; Castrichini, Matteo; Figueiral, Marta; Mohananey, Akanksha; Wang, Li; Gulati, Rajiv; Pellikka, Patricia A.; Pereira, Naveen L.] Mayo Clin, Dept Cardiovasc Dis, Rochester, MN 55905 USA.
   [Fazzini, Luca; Montisci, Roberta] Univ Cagliari, Dept Med Sci & Publ Hlth, Clin Cardiol Unit, Cagliari, Italy.
   [Hubers, Scott A.] United Hosp, Minneapolis Heart Inst, Nasseff Specialty Ctr, St Paul, MN USA.
   [Scott, Christopher G.] Mayo Clin, Dept Quantitat Hlth Sci, Rochester, MN 55905 USA.
C3 Mayo Clinic; University of Cagliari; Minneapolis Heart Institute
   Foundation; Mayo Clinic
RP Pereira, NL (corresponding author), Mayo Clin, Dept Cardiovasc Dis, Rochester, MN 55905 USA.
EM pereira.naveen@mayo.edu
RI Montisci, Roberta/HKW-3498-2023; Combaret, Nicolas/JAC-4248-2023;
   Castrichini, Matteo/AAK-2292-2020
OI Cao, Jenny/0000-0002-7167-004X; Fazzini, Luca/0000-0003-2407-7435
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NR 46
TC 0
Z9 0
U1 0
U2 0
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0894-7317
J9 J AM SOC ECHOCARDIOG
JI J. Am. Soc. Echocardiogr.
PD MAY
PY 2025
VL 38
IS 5
BP 421
EP 430
DI 10.1016/j.echo.2024.11.008
PG 10
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 2KX4W
UT WOS:001485097100001
PM 39613116
DA 2025-06-11
ER

PT J
AU Sucato, V
   Corrado, E
   Manno, G
   Amata, F
   Testa, G
   Novo, G
   Galassi, AR
AF Sucato, Vincenzo
   Corrado, Egle
   Manno, Girolamo
   Amata, Francesco
   Testa, Gabriella
   Novo, Giuseppina
   Galassi, Alfredo R.
TI Biomarkers of Coronary Microvascular Dysfunction in Patients With
   Microvascular Angina: A Narrative Review
SO ANGIOLOGY
LA English
DT Review
DE coronary microvascular dysfunction; microvascular angina; endothelial
   dysfunction; inflammation; oxidative stress; biomarkers
ID CARDIAC SYNDROME-X; C-REACTIVE PROTEIN; NITRIC-OXIDE SYNTHASE;
   PLASMINOGEN-ACTIVATOR RECEPTOR; CELL-ADHESION MOLECULE-1; PLASMA
   ENDOTHELIN LEVELS; HDL CHOLESTEROL RATIO; HEAT-SHOCK PROTEINS;
   ARTERY-DISEASE; ASYMMETRIC DIMETHYLARGININE
AB The current gold standard for diagnosis of coronary microvascular dysfunction (CMD) in the absence of myocardial diseases, whose clinical manifestation is microvascular angina (MVA), is reactivity testing using adenosine or acetylcholine during coronary angiography. This invasive test can be difficult to perform, expensive, and harmful. The identification of easily obtainable blood biomarkers which reflect the pathophysiology of CMD, characterized by high reliability, precision, accuracy, and accessibility may reduce risks and costs related to invasive procedures and even facilitate the screening and diagnosis of CMD. In this review, we summarized the results of several studies that have investigated the possible relationships between blood biomarkers involved with CMD and MVA. More specifically, we have divided the analyzed biomarkers into 3 different groups, according to the main mechanisms underlying CMD: biomarkers of "endothelial dysfunction," "vascular inflammation," and "oxidative stress." Finally, in the last section of the review, we consider mixed mechanisms and biomarkers which are not included in the 3 major categories mentioned above, but could be involved in the pathogenesis of CMD.
C1 [Sucato, Vincenzo; Corrado, Egle; Manno, Girolamo; Testa, Gabriella; Novo, Giuseppina] Univ Palermo, Univ Hosp Paolo Giaccone, Unit Cardiol, Palermo, Italy.
   [Sucato, Vincenzo; Corrado, Egle; Manno, Girolamo; Amata, Francesco; Testa, Gabriella; Novo, Giuseppina; Galassi, Alfredo R.] Univ Palermo, Internal Med & Specialties, Dept Excellence Sci Hlth Promot & Maternal, Via Vespro 147, I-90127 Palermo, Italy.
C3 University of Palermo; Policlinico Paolo Giaccone; University of Palermo
RP Manno, G (corresponding author), Univ Palermo, Internal Med & Specialties, Dept Excellence Sci Hlth Promot & Maternal, Via Vespro 147, I-90127 Palermo, Italy.
EM girolamomanno@hotmail.it
RI Sucato, Vincenzo/AAB-7272-2022; novo, giuseppina/K-6580-2016; Galassi,
   Andrea/AAC-4273-2022
OI Galassi, Alfredo/0000-0002-9366-2251; Sucato,
   Vincenzo/0000-0001-9514-1575; Amata, Francesco/0000-0003-3651-6765
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NR 117
TC 12
Z9 12
U1 0
U2 9
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0003-3197
EI 1940-1574
J9 ANGIOLOGY
JI Angiology
PD MAY
PY 2022
VL 73
IS 5
BP 395
EP 406
AR 00033197211034267
DI 10.1177/00033197211034267
EA AUG 2021
PG 12
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 0D7ZI
UT WOS:000680612300001
PM 34338554
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Beauchemin, M
   Geguchadze, R
   Guntur, AR
   Nevola, K
   Le, PT
   Barlow, D
   Rue, M
   Vary, CPH
   Lary, CW
   Motyl, KJ
   Houseknecht, KL
AF Beauchemin, Megan
   Geguchadze, Ramaz
   Guntur, Anyonya R.
   Nevola, Kathleen
   Le, Phuong T.
   Barlow, Deborah
   Rue, Megan
   Vary, Calvin P. H.
   Lary, Christine W.
   Motyl, Katherine J.
   Houseknecht, Karen L.
TI Exploring mechanisms of increased cardiovascular disease risk with
   antipsychotic medications: Risperidone alters the cardiac proteomic
   signature in mice
SO PHARMACOLOGICAL RESEARCH
LA English
DT Article
DE Antipsychotics; Risperidone; Olanzapine; Heart; Energy metabolism;
   Mitochondria
ID AUTONOMIC NERVOUS-SYSTEM; TRABECULAR BONE LOSS; ATYPICAL ANTIPSYCHOTICS;
   GENE-EXPRESSION; WEIGHT-GAIN; 2ND-GENERATION ANTIPSYCHOTICS;
   MITOCHONDRIAL DYSFUNCTION; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   BODYWEIGHT GAIN
AB Atypical antipsychotic (AA) medications including risperidone (RIS) and olanzapine (OLAN) are FDA approved for the treatment of psychiatric disorders including schizophrenia, bipolar disorder and depression. Clinical side effects of AA medications include obesity, insulin resistance, dyslipidemia, hypertension and increased cardiovascular disease risk. Despite the known pharmacology of these AA medications, the mechanisms contributing to adverse metabolic side-effects are not well understood. To evaluate drug-associated effects on the heart, we assessed changes in the cardiac proteomic signature in mice administered for 4 weeks with clinically relevant exposure of RIS or OLAN. Using proteomic and gene enrichment analysis, we identified differentially expressed (DE) proteins in both RIS- and OLAN-treated mouse hearts (p < 0.05), including proteins comprising mitochondrial respiratory complex I and pathways involved in mitochondrial function and oxidative phosphorylation. A subset of DE proteins identified were further validated by both western blotting and quantitative realtime PCR. Histological evaluation of hearts indicated that AA-associated aberrant cardiac gene expression occurs prior to the onset of gross pathomorphological changes. Additionally, RIS treatment altered cardiac mitochondrial oxygen consumption and whole body energy expenditure. Our study provides insight into the mechanisms underlying increased patient risk for adverse cardiac outcomes with-chronic treatment of AA medications.
C1 [Beauchemin, Megan; Geguchadze, Ramaz; Barlow, Deborah; Houseknecht, Karen L.] Univ New England, Coll Osteopath Med, Biddeford, ME USA.
   [Guntur, Anyonya R.; Le, Phuong T.] Maine Med Ctr, Res Inst, Ctr Clin & Translat Res, Scarborough, ME USA.
   [Nevola, Kathleen; Rue, Megan; Vary, Calvin P. H.; Motyl, Katherine J.] Maine Med Ctr, Res Inst, Ctr Mol Med, Scarborough, ME USA.
   [Nevola, Kathleen] Tufts Univ, Sackler Sch Grad Biomed Res, Boston, MA 02111 USA.
   [Nevola, Kathleen; Lary, Christine W.] Maine Med Ctr, Res Inst, Ctr Outcomes Res & Evaluat, Portland, ME 04102 USA.
C3 University of New England - Maine; Maine Medical Center; Maine Medical
   Center; Tufts University; Maine Medical Center
RP Houseknecht, KL (corresponding author), Univ New England, Dept Biomed Sci, 11 Hills Beach Rd, Biddeford, ME 04005 USA.
EM khouseknecht@une.edu
RI Le, Phuong/B-3959-2019
FU National Institute of Health NIDDK [DK095143]; National Institute of
   Health NIAMS [AR067858]; National Institute of NIGMS [GM121301]
FX This work was supported by the National Institutes of Health NIDDK award
   number DK095143 to KLH; NIAMS award number AR067858 and NIGMS award
   number GM121301 to KJM.
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NR 108
TC 20
Z9 21
U1 1
U2 16
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 1043-6618
J9 PHARMACOL RES
JI Pharmacol. Res.
PD FEB
PY 2020
VL 152
AR 104589
DI 10.1016/j.phrs.2019.104589
PG 15
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA KT0KU
UT WOS:000518700200021
PM 31874253
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Cinar, R
   Iyer, MR
   Kunos, G
AF Cinar, Resat
   Iyer, Malliga R.
   Kunos, George
TI The therapeutic potential of second and third generation CB1R
   antagonists
SO PHARMACOLOGY & THERAPEUTICS
LA English
DT Review
DE Peripheral CB1R antagonists; Endocannabinoids; Hybrid drugs;
   Polypharmacology; Multi-target drugs; Fibrosis; Obesity; Diabetes
ID NITRIC-OXIDE SYNTHASE; CANNABINOID RECEPTOR 1; CARDIOMETABOLIC
   RISK-FACTORS; INDUCED INSULIN-RESISTANCE; INDUCED PULMONARY-FIBROSIS;
   ENDOCANNABINOID SYSTEM; OXIDATIVE STRESS; WEIGHT-LOSS; ENDOGENOUS
   CANNABINOIDS; BODY-WEIGHT
AB Endocannabinoids acting via CB1 receptors (CB1R) play a critical role in regulating energy homeostasis, which was the rationale for the pharmaceutical development of CB1R antagonists for the treatment of obesity. Although the first-in-class CB1R antagonist rimonabant proved to be effective in mitigating obesity and its multiple cardio-metabolic complications, it was withdrawn from clinical use due to CNS-mediated neuropsychiatric side effects, which halted the further therapeutic development of the whole class of these compounds. Compared to the brain, CB(1)Rs are expressed at low yet functional levels in peripheral organs involved in regulating energy homeostasis, including liver, skeletal muscle, adipose tissue and endocrine pancreas. In recent preclinical studies, selective targeting of these receptors by 'second generation' peripherally restricted CB1R antagonists replicated the metabolic benefits of rimonabant in rodent models of obesity and diabetes without causing CNS-mediated side effects. Increased CB1R activity also contributes to complex, multifactorial disorders such as various forms of tissue fibrosis, treatment of which may benefit from simultaneous engagement of more than one therapeutic target. Accordingly, novel 'third generation' hybrid inhibitors of peripheral CB1R and inducible NO synthase were tested in mouse models of liver and pulmonary fibrosis where their antifibrotic efficacy was found to exceed the efficacy of drugs that inhibit only one of these targets. In this review, we will discuss the challenges and opportunities offered by second and third generation CB1R antagonists and their potential therapeutic uses. Published by Elsevier Inc.
C1 [Cinar, Resat; Iyer, Malliga R.; Kunos, George] NIAAA, Lab Physiol Studies, NIH, 5625 Fishers Lane,Room 2S-18, Bethesda, MD 20892 USA.
C3 National Institutes of Health (NIH) - USA; NIH National Institute on
   Alcohol Abuse & Alcoholism (NIAAA)
RP Cinar, R; Iyer, MR (corresponding author), NIAAA, Lab Physiol Studies, NIH, 5625 Fishers Lane,Room 2S-18, Bethesda, MD 20892 USA.
EM resat.cinar@nih.gov; malliga.iyer@nih.gov
RI Cinar, Resat/H-7219-2019; CINAR, RESAT/E-5755-2010
OI CINAR, RESAT/0000-0002-8597-7253
FU National Institute on Alcohol Abuse and Alcoholism
FX This work was supported by intramural funds from the National Institute
   on Alcohol Abuse and Alcoholism.
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NR 225
TC 105
Z9 109
U1 2
U2 20
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0163-7258
EI 1879-016X
J9 PHARMACOL THERAPEUT
JI Pharmacol. Ther.
PD APR
PY 2020
VL 208
AR 107477
DI 10.1016/j.pharmthera.2020.107477
PG 24
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA KY5TF
UT WOS:000522634400012
PM 31926199
OA hybrid, Green Accepted
DA 2025-06-11
ER

PT J
AU Shenassa, ED
   Williams, AD
AF Shenassa, Edmond D.
   Williams, Andrew D.
TI Concomitant exposure to area-level poverty, ambient air volatile organic
   compounds, and cardiometabolic dysfunction: a cross-sectional study of
   US adolescents
SO ANNALS OF EPIDEMIOLOGY
LA English
DT Article
DE Social determinants of health; Area-level poverty; Adolescent health;
   Cardiometabolic risk factors; Air pollution
ID SOCIOECONOMIC MEASURES; POLLUTION EXPOSURES; INSULIN-RESISTANCE;
   EMISSION CHANGES; ALLOSTATIC LOAD; HEART-DISEASE; RISK-FACTORS; HEALTH;
   ASSOCIATIONS; STRESS
AB Purpose: A key to better understanding the influence of the place of residence on cardiometabolic function is the effect of concomitant exposure to both air pollution and residence in economically marginalized areas. We hypothesized that, among adolescents, the association between air pollution and cardiometabolic function is exacerbated among residents of economically marginalized areas.
   Methods: In this cross-sectional study, individual-level data on cardiometabolic function collected from a representative sample of U.S. adolescents in the National Health and Nutrition Examination Survey (n = 10,415) were merged with data on area-level poverty (U.S. decennial survey and American Community Survey) and air pollution levels (National-Scale Air Toxics Assessment) using contemporary census-tract identifiers. We excluded respondents who were pregnant, had hypertension or diabetes or using medication for hypertension or diabetes, or with missing data on outcome variables.
   Results: We observed a significant interaction between area-level poverty and air pollution. Among residents of high-poverty areas, exposure to high levels of air pollution predicted a 30% elevated odds of cardiometabolic dysfunction (OR = 1.30; 95% CI: 1.04, 1.61), whereas in low-poverty areas, exposure to high levels of air pollution was not associated with elevated odds of cardiometabolic dysfunction (OR = 1.04; 95% CI: 0.85, 1.28).
   Conclusions: Our findings suggest that the cardiometabolic consequences of air pollution are more readily realized among residents of economically marginalized areas. Structural remedies are discussed. (C) 2020 Elsevier Inc. All rights reserved.
C1 [Shenassa, Edmond D.] Univ Maryland, Maternal & Child Hlth Program, Dept Family Sci, 4200 Valley Dr, College Pk, MD 20742 USA.
   [Shenassa, Edmond D.] Univ Maryland, Dept Epidemiol & Biostat, College Pk, MD 20742 USA.
   [Shenassa, Edmond D.] Brown Univ, Dept Epidemiol & Biostat, Sch Publ Hlth, Providence, RI 02912 USA.
   [Shenassa, Edmond D.] Univ Maryland, Sch Med, Dept Epidemiol & Biostat, Baltimore, MD 21201 USA.
   [Williams, Andrew D.] Univ North Dakota, Sch Med & Hlth Sci, Publ Hlth Program, Grand Forks, ND USA.
C3 University System of Maryland; University of Maryland College Park;
   University System of Maryland; University of Maryland College Park;
   Brown University; University System of Maryland; University of Maryland
   Baltimore; University of North Dakota Grand Forks
RP Shenassa, ED (corresponding author), Univ Maryland, Maternal & Child Hlth Program, Dept Family Sci, 4200 Valley Dr, College Pk, MD 20742 USA.
EM shenassa@umd.edu
FU Maryland Population Research Center; University of Maryland Graduate
   School
FX The authors would like to thank Cole Hunt fro his help reviewing the
   literature. This work was supported by grants from Maryland Population
   Research Center and University of Maryland Graduate School to E.D.S.
   This study was based on secondary analysis of anonymized data andwas
   considered exempt by the institutional review board at the University of
   Maryland.
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NR 65
TC 6
Z9 7
U1 0
U2 7
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1047-2797
EI 1873-2585
J9 ANN EPIDEMIOL
JI Ann. Epidemiol.
PD AUG
PY 2020
VL 48
BP 15
EP 22
DI 10.1016/j.annepidem.2020.05.014
PG 8
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA MY9OL
UT WOS:000558750800003
PM 32778227
DA 2025-06-11
ER

PT J
AU Moradi, F
   Maleki, V
   Saleh-Ghadimi, S
   Kooshki, F
   Gargari, BP
AF Moradi, Fardin
   Maleki, Vahid
   Saleh-Ghadimi, Sevda
   Kooshki, Fatemeh
   Gargari, Bahram Pourghassem
TI Potential roles of chromium on inflammatory biomarkers in diabetes: A
   Systematic
SO CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
LA English
DT Review
DE chromium; diabetes mellitus; inflammation; systematic review
ID HIGH-FAT DIET; OXIDATIVE STRESS; INSULIN-RESISTANCE; TNF-ALPHA;
   DINICOCYSTEINATE SUPPLEMENTATION; SKELETAL-MUSCLE; PICOLINATE
   SUPPLEMENTATION; GLUT-4 TRANSLOCATION; LIPID-PEROXIDATION; 3T3-L1
   ADIPOCYTES
AB Diabetes, as a low-grade chronic inflammatory disease, causes disruption in proper function of immune and metabolic system. Chromium is an important element required for normal lipid and glucose metabolism. Chromium deficiency is correlated with elevation in cardiometabolic risk, which results from increased inflammation. This systematic review was conducted to discover the potential roles of chromium on inflammatory biomarkers. Eligible studies were all in vitro, animal and human studies published in English-language journals from inception until October 2018. PubMed, Scopus, Embase, ProQuest and Google Scholar databases were searched to fined interventional studies from the effects of chromium on inflammatory biomarkers such as tumour necrosis factor a (TNF-a), C-reactive protein (CRP), interleukins, monocyte chemoattractant protein-1 (MCP-1), intercellular adhesion molecule-1 (ICAM-1) and adipocytokines in hyperglycaemia and diabetes. Out of 647 articles found in the search, only 14 articles were eligible for analysis, three in vitro studies, eight animal studies and three human studies. Twelve of the 14 studies included in this review, chromium significantly decreased inflammatory factors. The findings of this review indicate, based on in vitro and in vivo studies, that chromium might have potential anti-inflammatory properties, but some of the studies did not show anti-inflammatory effects for chromium (two studies). There are only three studies in humans with controversial results. Therefore, more consistent randomized double-blind controlled trials are needed to reach relevant clinical recommendations, as well as to determine the precise mechanism, of chromium on inflammation in diabetes.
C1 [Moradi, Fardin; Maleki, Vahid; Saleh-Ghadimi, Sevda; Kooshki, Fatemeh] Tabriz Univ Med Sci, Fac Nutr & Food Sci, Tabriz, Iran.
   [Gargari, Bahram Pourghassem] Tabriz Univ Med Sci, Fac Nutr & Food Sci, Nutr Res Ctr, Tabriz, Iran.
C3 Tabriz University of Medical Science; Tabriz University of Medical
   Science
RP Gargari, BP (corresponding author), Tabriz Univ Med Sci, Fac Nutr & Food Sci, Nutr Res Ctr, Tabriz, Iran.
EM pourghassemb@tbzmed.ac.ir
RI Saleh-Ghadimi, Sevda/ABD-2355-2021; Maleki, Vahid/JXM-7786-2024;
   Pourghassem Gargari, Bahram/D-3556-2017
OI Pourghassem Gargari, Bahram/0000-0001-7667-099X
FU Nutrition Research Centre of Tabriz University of Medical Sciences
FX The authors would like to thank the Nutrition Research Centre of Tabriz
   University of Medical Sciences for their support.
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NR 92
TC 23
Z9 25
U1 1
U2 20
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0305-1870
EI 1440-1681
J9 CLIN EXP PHARMACOL P
JI Clin. Exp. Pharmacol. Physiol.
PD NOV
PY 2019
VL 46
IS 11
BP 975
EP 983
DI 10.1111/1440-1681.13144
EA AUG 2019
PG 9
WC Pharmacology & Pharmacy; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Physiology
GA JF0KS
UT WOS:000488399100001
PM 31330062
OA Bronze
DA 2025-06-11
ER

PT J
AU Gutierrez-Repiso, C
   Garcia-Serrano, S
   Rodriguez-Pacheco, F
   Garcia-Escobar, E
   Haro-Mora, JJ
   Garcia-Arnes, J
   Valdes, S
   Gonzalo, M
   Soriguer, F
   Moreno-Ruiz, FJ
   Rodriguez-Cañete, A
   Martinez-Ferriz, A
   Santoyo, JS
   Perez-Valero, V
   Garcia-Fuentes, E
AF Gutierrez-Repiso, Carolina
   Garcia-Serrano, Sara
   Rodriguez-Pacheco, Francisca
   Garcia-Escobar, Eva
   Haro-Mora, Juan J.
   Garcia-Arnes, Juan
   Valdes, Sergio
   Gonzalo, Montserrat
   Soriguer, Federico
   Moreno-Ruiz, Francisco J.
   Rodriguez-Canete, Alberto
   Martinez-Ferriz, Abelardo
   Santoyo, Julio S.
   Perez-Valero, Vidal
   Garcia-Fuentes, Eduardo
TI FNDC5 could be regulated by leptin in adipose tissue
SO EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
LA English
DT Article
DE Adipose tissue; FNDC5; irisin; leptin; morbid obesity; PCG1-alpha;
   waist-to-hip ratio
ID Y GASTRIC BYPASS; BODY-MASS INDEX; INSULIN-RESISTANCE; MORBIDLY OBESE;
   WAIST CIRCUMFERENCE; BARIATRIC SURGERY; OXIDATIVE STRESS; IRISIN;
   EXPRESSION; FAT
AB Introduction Irisin activates the thermogenic function in adipose tissues. However, little is known on the association between human irisin and different cardiometabolic risk factors. We analyse the influence of morbid obesity on irisin levels and its relation with leptin and different cardiovascular risk factors.
   Material and methods We measured the serum irisin level and the fibronectin type III domain containing 5 (FNDC5) expression in adipose tissue from 33 morbidly obese subjects and 12 nonobese subjects. We also studied the effect of leptin on FNDC5 expression.
   Results Serum irisin was higher in the nonobese subjects than in morbidly obese subjects, both before (P = 0.043) and after bariatric surgery (P = 0.042). The variable that best explained the serum irisin levels in a multiple linear regression model was the waist-to-hip ratio (WHR) (R-2 = 0.201) (Beta = -0.357, P = 0.046). Those morbidly obese subjects with android-type obesity had lower serum irisin levels than those with gynecoid-type obesity, both before (P = 0.027) and after bariatric surgery (P = 0.006). Only the percentage change in WHR was associated with serum irisin levels after bariatric surgery (r = -0.529, P = 0.005). FNDC5 expression levels in subcutaneous adipose tissue (SAT) were higher in the nonobese than in the morbidly obese subjects (P = 0.042). In SAT explants from nonobese subjects, leptin (20 and 150 ng/mL) produced a decrease in FNDC5 expression (P = 0.009 and P = 0.037, respectively).
   Conclusions We showed decreased serum irisin levels in morbidly obese subjects, related mainly to WHR. FNDC5 expression could be regulated by leptin.
C1 [Gutierrez-Repiso, Carolina; Garcia-Serrano, Sara; Rodriguez-Pacheco, Francisca; Garcia-Escobar, Eva; Haro-Mora, Juan J.; Garcia-Arnes, Juan; Valdes, Sergio; Gonzalo, Montserrat; Soriguer, Federico; Garcia-Fuentes, Eduardo] Hosp Reg Univ, Inst Invest Biomed Malaga IBIMA, Unidad Gest Clin Endocrinol & Nutr, Malaga 29009, Spain.
   [Garcia-Serrano, Sara; Garcia-Escobar, Eva; Valdes, Sergio; Soriguer, Federico] Inst Salud Carlos III, CIBERDEM, Malaga, Spain.
   [Soriguer, Federico; Garcia-Fuentes, Eduardo] Inst Salud Carlos III, CIBEROBN, Malaga, Spain.
   [Moreno-Ruiz, Francisco J.; Rodriguez-Canete, Alberto; Martinez-Ferriz, Abelardo; Santoyo, Julio S.] Hosp Reg Univ, Inst Invest Biomed Malaga IBIMA, Unidad Gest Clin Cirugia Gen Digest & Trasplantes, Malaga 29009, Spain.
   [Perez-Valero, Vidal] Hosp Reg Univ, Inst Invest Biomed Malaga IBIMA, Unidad Gest Clin Lab, Malaga 29009, Spain.
C3 Universidad de Malaga; Instituto de Investigacion Biomedica de Malaga y
   Plataforma en Nanomedicina (IBIMA); CIBER - Centro de Investigacion
   Biomedica en Red; CIBERDEM; Instituto de Salud Carlos III; Instituto de
   Salud Carlos III; CIBER - Centro de Investigacion Biomedica en Red;
   CIBEROBN; Universidad de Malaga; Instituto de Investigacion Biomedica de
   Malaga y Plataforma en Nanomedicina (IBIMA); Instituto de Investigacion
   Biomedica de Malaga y Plataforma en Nanomedicina (IBIMA); Universidad de
   Malaga
RP Garcia-Fuentes, E (corresponding author), Hosp Reg Univ, Unidad Gest Clin Endocrinol & Nutr, Plaza Hosp Civil S-N, Malaga 29009, Spain.
EM paqui.endocrino@gmail.com; edugf1@gmail.com
RI Garcia-Fuentes, Eduardo/AAB-1607-2020; Gutiérrez-Repiso,
   Carolina/F-8125-2010; Santoyo, Julio/K-1128-2012; Haro-Mora, Juan
   Jesus/F-6113-2010
OI GARCIA-FUENTES, EDUARDO/0000-0002-3491-2724; Gutierrez Repiso,
   Carolina/0000-0002-5842-8873; Santoyo, Julio/0000-0001-6861-1121;
   GARCIA-ESCOBAR, EVA/0000-0002-0134-3473; Haro-Mora, Juan
   Jesus/0000-0002-6679-7812
FU Instituto de Salud Carlos III [PS09/01060]; Consejeria de Economia,
   lnnovacion, Ciencia y Empresa de la Junta de Andalucia [CTS-8081]
FX This work was supported in part by a grant from the Instituto de Salud
   Carlos III (PS09/01060) and Consejeria de Economia, lnnovacion, Ciencia
   y Empresa de la Junta de Andalucia (CTS-8081).
CR [Anonymous], 2011, Waist Circumference and Waist-Hip Ratio: Report of a WHO Expert Consultation
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NR 33
TC 38
Z9 40
U1 0
U2 14
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0014-2972
EI 1365-2362
J9 EUR J CLIN INVEST
JI Eur. J. Clin. Invest.
PD OCT
PY 2014
VL 44
IS 10
BP 918
EP 925
DI 10.1111/eci.12324
PG 8
WC Medicine, General & Internal; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Research & Experimental Medicine
GA AQ4ML
UT WOS:000342771500004
PM 25112714
DA 2025-06-11
ER

PT J
AU Guo, TT
   Zou, Q
   Wang, Q
   Zhang, Y
   Zhong, XY
   Lin, HT
   Gong, WX
   Wang, YB
   Xie, K
   Wu, KP
   Chen, F
   Chen, W
AF Guo, Tingting
   Zou, Qing
   Wang, Qi
   Zhang, Yi
   Zhong, Xinyuan
   Lin, Hantong
   Gong, Wenxuan
   Wang, Yingbo
   Xie, Kun
   Wu, Kunpeng
   Chen, Feng
   Chen, Wen
TI Association of TyG Index and TG/HDL-C Ratio with Trajectories of
   Depressive Symptoms: Evidence from China Health and Retirement
   Longitudinal Study
SO NUTRIENTS
LA English
DT Article
DE trajectory; depressive symptoms; triglyceride-glucose (TyG) index;
   TG/HDL-C ratio; longitudinal study
ID LONG-TERM TRAJECTORIES; INSULIN-RESISTANCE; OLDER-ADULTS; SHORT-FORM;
   METABOLIC SYNDROME; METAANALYSIS; POPULATION; PREVALENCE; DISORDER;
   PREDICTORS
AB Objectives: To explore whether the triglyceride-glucose (TyG) index and the triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio are associated with the trajectories of depressive symptoms. Methods: In this longitudinal study, 4215 participants aged 45 years and older were recruited from the China Health and Retirement Longitudinal Study from 2011 to 2018. The trajectories of depressive symptoms, measured by the 10-item Center for Epidemiologic Studies Depression Scale (CESD-10), were identified using group-based trajectory modeling. Multinomial logistic models and restricted cubic spline analysis were used to investigate the relationships between the TyG index and the TG/HDL-C ratio and the trajectories of depressive symptoms. Stratified analyses were conducted based on sex, age, place of residence, and body mass index (BMI). Results: Five distinct trajectories of depressive symptoms characterized by stable low, stable moderate, decreasing, increasing, and stable high were identified during a follow-up of 7 years. The associations of the TyG index and the TG/HDL-C ratio with trajectories of depressive symptoms are not entirely consistent. After adjusting for covariates, a higher TyG index at baseline was associated with lower odds of being on the decreasing trajectory of depressive symptoms (ORad = 0.61, 95% CI: 0.40-0.92) compared to the stable low trajectory, and restricted cubic spline analysis revealed a negative linear relationship between the TyG index and the likelihood of a decreasing trajectory of depressive symptoms. However, the relationship between the TG/HDL-C ratio and the decreasing trajectory of depressive symptoms was no longer statistically significant when all confounders were controlled (ORad = 0.72, 95% CI: 0.50-1.04). Additionally, this negative association between the TyG index and decreasing trajectory of depressive symptoms was observed among 45-64-year-old individuals, female participants, those living in rural areas, and those with a normal BMI. Limitations: This study was conducted in a middle-aged and elderly population in China, and extrapolation to other regions and populations requires further confirmation. Conclusions: Compared to the TG/HDL-C ratio, the TyG index may be a better predictor for trajectories of depressive symptoms in middle-aged and older adults. Considering that the pathology of depression progresses long term, our findings may have utility for identifying available and reliable markers for the development of depression.
C1 [Guo, Tingting; Zou, Qing; Wang, Qi; Zhang, Yi; Zhong, Xinyuan; Lin, Hantong; Gong, Wenxuan; Wang, Yingbo; Xie, Kun; Wu, Kunpeng; Chen, Wen] Sun Yat Sen Univ, Sch Publ Hlth, Dept Med Stat, 74 Zhongshan Second Rd, Guangzhou 510080, Peoples R China.
   [Chen, Feng] Sun Yat sen Univ, Affiliated Hosp 8, Dept Clin Res, 3025 Shennan Zhong Rd, Shenzhen 518033, Peoples R China.
   [Chen, Wen] Sun Yat Sen Univ, Ctr Migrant Hlth Policy, 74 Zhongshan Second Rd, Guangzhou 510080, Peoples R China.
C3 Sun Yat Sen University; Sun Yat Sen University; Sun Yat Sen University
RP Chen, W (corresponding author), Sun Yat Sen Univ, Sch Publ Hlth, Dept Med Stat, 74 Zhongshan Second Rd, Guangzhou 510080, Peoples R China.; Chen, W (corresponding author), Sun Yat Sen Univ, Ctr Migrant Hlth Policy, 74 Zhongshan Second Rd, Guangzhou 510080, Peoples R China.
EM guott6@mail2.sysu.edu.cn; zouq25@mail2.sysu.edu.cn;
   wangq633@mail2.sysu.edu.cn; zhangy2553@mail2.sysu.edu.cn;
   zhongxy85@mail2.sysu.edu.cn; linht35@mail2.sysu.edu.cn;
   gongwx5@mail2.sysu.edu.cn; wangyb68@mail2.sysu.edu.cn;
   xiek9@mail2.sysu.edu.cn; wukp6@mail2.sysu.edu.cn;
   chenf329@mail.sysu.edu.cn; chenw43@mail.sysu.edu.cn
OI , wen/0000-0002-6839-8890
FU Natural Science Foundation of Guangdong Province for Distinguished Young
   Scholars; Science and Technology Program of Guangzhou [2024A04J6551]; 
   [2022B1515020094]
FX This research was funded by the Natural Science Foundation of Guangdong
   Province for Distinguished Young Scholars (Grant number:
   2022B1515020094), and the Science and Technology Program of Guangzhou
   (Grant number: 2024A04J6551).
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NR 107
TC 0
Z9 0
U1 7
U2 7
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD DEC
PY 2024
VL 16
IS 24
AR 4300
DI 10.3390/nu16244300
PG 20
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA Q4M5J
UT WOS:001384443300001
PM 39770920
OA gold
DA 2025-06-11
ER

PT J
AU Chen, XJ
   Zhang, Z
   Yang, HJ
   Qiu, PS
   Wang, HZ
   Wang, F
   Zhao, Q
   Fang, J
   Nie, JY
AF Chen, Xiaojia
   Zhang, Zhang
   Yang, Huijie
   Qiu, Peishan
   Wang, Haizhou
   Wang, Fan
   Zhao, Qiu
   Fang, Jun
   Nie, Jiayan
TI Consumption of ultra-processed foods and health outcomes: a systematic
   review of epidemiological studies
SO NUTRITION JOURNAL
LA English
DT Review
DE Ultra-processed foods; Noncommunicable diseases; Health; Systematic
   review
ID SEGUIMIENTO UNIVERSIDAD; MEDITERRANEAN COHORT; DIET QUALITY; ALL-CAUSE;
   MORTALITY; OBESITY; DISEASE; RISK; ASSOCIATION; SUGARS
AB Background Consumption of ultra-processed foods (UPFs) plays a potential role in the development of obesity and other diet-related noncommunicable diseases (NCDs), but no studies have systematically focused on this. This study aimed to summarize the evidence for the association between UPFs consumption and health outcomes. Methods A comprehensive search was conducted in PubMed, Embase, and Web of Science to identify all relevant studies. Epidemiological studies were included, and identified studies were evaluated for risk of bias.A narrative review of the synthesized findings was provided to assess the association between UPFs consumption and health outcomes. Results 20 studies (12 cohort and 8 cross-sectional studies) were included in the analysis, with a total of 334,114 participants and 10 health outcomes. In a narrative review, high UPFs consumption was obviously associated with an increased risk of all-cause mortality, overall cardiovascular diseases, coronary heart diseases, cerebrovascular diseases, hypertension, metabolic syndrome, overweight and obesity, depression, irritable bowel syndrome, overall cancer, postmenopausal breast cancer, gestational obesity, adolescent asthma and wheezing, and frailty. It showed no significant association with cardiovascular disease mortality, prostate and colorectal cancers, gestational diabetes mellitus and gestational overweight. Conclusions This study indicated a positive association between UPFs consumption and risk of several health outcomes. Large-scale prospective designed studies are needed to confirm our findings.
C1 [Chen, Xiaojia; Zhang, Zhang; Yang, Huijie; Qiu, Peishan; Wang, Haizhou; Wang, Fan; Zhao, Qiu; Fang, Jun; Nie, Jiayan] Wuhan Univ, Zhongnan Hosp, Dept Gastroenterol, 169 Donghu Rd, Wuhan 430071, Hubei, Peoples R China.
   [Chen, Xiaojia; Zhang, Zhang; Yang, Huijie; Qiu, Peishan; Wang, Haizhou; Wang, Fan; Zhao, Qiu; Fang, Jun; Nie, Jiayan] Hubei Clin Ctr, Wuhan, Peoples R China.
   [Chen, Xiaojia; Zhang, Zhang; Yang, Huijie; Qiu, Peishan; Wang, Haizhou; Wang, Fan; Zhao, Qiu; Fang, Jun; Nie, Jiayan] Key Lab Intestinal & Colorectal Dis, Wuhan, Peoples R China.
C3 Wuhan University
RP Zhao, Q; Fang, J; Nie, JY (corresponding author), Wuhan Univ, Zhongnan Hosp, Dept Gastroenterol, 169 Donghu Rd, Wuhan 430071, Hubei, Peoples R China.
EM zhaoqiuwhu@163.com; xhfangjun@163.com; 119140546@qq.com
RI Yang, Huijie/D-6458-2013; Chen, Xiaojia/JYV-2395-2024
OI zhao, qiu/0000-0002-3230-6077
FU National Key RAMP;D Program of China [2017YFC0112302]
FX National Key R&D Program of China (2017YFC0112302).
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NR 66
TC 317
Z9 327
U1 8
U2 84
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1475-2891
J9 NUTR J
JI Nutr. J.
PD AUG 20
PY 2020
VL 19
IS 1
AR 86
DI 10.1186/s12937-020-00604-1
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nutrition & Dietetics
GA NJ7OV
UT WOS:000566233400001
PM 32819372
OA Green Published, gold
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Li, JM
   Eriksson, M
   He, W
   Hall, P
   Czene, K
AF Li, Jingmei
   Eriksson, Mikael
   He, Wei
   Hall, Per
   Czene, Kamila
TI Associations between childhood body size and seventeen adverse outcomes:
   analysis of 65,057 European women
SO SCIENTIFIC REPORTS
LA English
DT Article
ID MASS INDEX; BREAST-CANCER; FOLLOW-UP; METABOLIC SYNDROME; DIFFERENT
   PERIODS; LIFE-COURSE; RISK; CHILDREN; OBESITY; ADOLESCENTS
AB Large childhood body size has been consistently shown to be associated with decreased breast cancer risk. However, it is important to consider the effects of a large childhood body size on other adult diseases. It is not clear if the associations between childhood body size and adult diseases will persist if they later attain healthy weight. The associations between body size at age 7 and 17 adverse outcomes in adulthood were examined using Cox models in a Swedish study of 65,057 women. Large body size at age 7, when compared to small body size, was associated with decreased risk for breast cancer (HR [95% CI]: 0.81 [0.70-0.93]) and increased risks for anorexia (2.13 [1.63-2.77]) and bulimia (1.91 [1.35-2.70]). Neither adjusting for adult BMI nor restricting the dataset to lean adults (BMI < 25 kg/m(2)) attenuated the associations. While large body size at age 7 by itself was positively associated with increased risks of diabetes (1.34 [1.16-1.55]), PCOS (1.69 [1.13-2.51]) and hypertension (before age 60), the associations were no longer significant after controlling for adult BMI. No clear associations were found with the remaining adverse outcomes (cervical, uterine, melanoma, colon cancer, depression, ovarian cyst, stroke, hyperlipidemia, heart failure, myocardial infarction, and angina pectoris).
C1 [Li, Jingmei] Genome Inst Singapore, 60 Biopolis St,Genome 02-01, Singapore 138672, Singapore.
   [Li, Jingmei] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Surg, Singapore 119228, Singapore.
   [Li, Jingmei; Eriksson, Mikael; He, Wei; Hall, Per; Czene, Kamila] Karolinska Inst, Dept Med Epidemiol & Biostat, Box 281, S-17177 Stockholm, Sweden.
   [Hall, Per] Soder Sjukhuset, Dept Oncol, S-11884 Stockholm, Sweden.
C3 Agency for Science Technology & Research (A*STAR); A*STAR - Genome
   Institute of Singapore (GIS); National University of Singapore;
   Karolinska Institutet; Sodersjukhuset Hospital
RP Li, JM (corresponding author), Genome Inst Singapore, 60 Biopolis St,Genome 02-01, Singapore 138672, Singapore.; Li, JM (corresponding author), Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Surg, Singapore 119228, Singapore.; Li, JM (corresponding author), Karolinska Inst, Dept Med Epidemiol & Biostat, Box 281, S-17177 Stockholm, Sweden.
EM lijm1@gis.a-star.edu.sg
RI ; Li, Jingmei/I-2904-2012; He, Wei/C-8441-2015
OI eriksson, mikael/0000-0001-8135-4270; Li, Jingmei/0000-0001-8587-7511;
   He, Wei/0000-0003-0161-3274
FU Marit and Hans Rausing Initiative Against Breast Cancer; Swedish
   Research Council [2014-2271]; Swedish Cancer Society [CAN 2016/684];
   FORTE [2016-00081]; Karolinska Institutet (Karolinska Institutets
   forskningsbidrag) [2016fobi47643]; Singapore National Research
   Foundation Fellowship; Forte [2016-00081] Funding Source: Forte
FX The KARMA study was supported by the Marit and Hans Rausing Initiative
   Against Breast Cancer, the Swedish Research Council (2014-2271); Swedish
   Cancer Society (CAN 2016/684); and FORTE (2016-00081). This work was
   also supported by a research grant from Karolinska Institutet
   (Karolinska Institutets forskningsbidrag (2016fobi47643)). JL is a
   recipient of a Singapore National Research Foundation Fellowship. The
   funding agencies had no role in the study design; in the collection,
   analysis, and interpretation of data; in the writing of the report; and
   in the decision to submit the article for publication. We thank the
   reviewers for their careful reviews and helpful comments.
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NR 59
TC 9
Z9 9
U1 0
U2 2
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD DEC 5
PY 2017
VL 7
AR 16917
DI 10.1038/s41598-017-17258-5
PG 10
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA FO7JP
UT WOS:000417050200007
PM 29208999
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Sarzynski, MA
   Rice, TK
   Despres, JP
   Perusse, L
   Tremblay, A
   Stanforth, PR
   Tchernof, A
   Barber, JL
   Falciani, F
   Clish, C
   Robbins, JM
   Ghosh, S
   Gerszten, RE
   Leon, AS
   Skinner, JS
   Rao, DC
   Bouchard, C
AF Sarzynski, Mark A.
   Rice, Treva K.
   Despres, Jean-Pierre
   Perusse, Louis
   Tremblay, Angelo
   Stanforth, Philip R.
   Tchernof, Andre
   Barber, Jacob L.
   Falciani, Francesco
   Clish, Clary
   Robbins, Jeremy M.
   Ghosh, Sujoy
   Gerszten, Robert E.
   Leon, Arthur S.
   Skinner, James S.
   Rao, D. C.
   Bouchard, Claude
TI The HERITAGE Family Study: A Review of the Effects of Exercise Training
   on Cardiometabolic Health, with Insights into Molecular Transducers
SO MEDICINE & SCIENCE IN SPORTS & EXERCISE
LA English
DT Review
DE EXERCISE GENOMICS; HERITABILITY; EXERCISE TRAINING; CARDIOMETABOLIC RISK
   FACTORS; EXERCISE AND GENE EXPRESSION; EXERCISE AND PROTEOMICS; EXERCISE
   AND METABOLOMICS; EXERCISE AND BIOINFORMATICS
ID RESTING METABOLIC-RATE; WIDE LINKAGE SCAN; HORMONE-BINDING GLOBULIN;
   AGOUTI-RELATED PROTEIN; DENSITY-LIPOPROTEIN CHOLESTEROL; MAXIMAL AEROBIC
   CAPACITY; QUANTITATIVE TRAIT LOCUS; VISCERAL ADIPOSE-TISSUE; FIBER-TYPE
   PROPORTION; LEPTIN RECEPTOR GENE
AB The aim of the HERITAGE Family Study was to investigate individual differences in response to a standardized endurance exercise program, the role of familial aggregation, and the genetics of response levels of cardiorespiratory fitness and cardiovascular disease and diabetes risk factors. Here we summarize the findings and their potential implications for cardiometabolic health and cardiorespiratory fitness. It begins with overviews of background and planning, recruitment, testing and exercise program protocol, quality control measures, and other relevant organizational issues. A summary of findings is then provided on cardiorespiratory fitness, exercise hemodynamics, insulin and glucose metabolism, lipid and lipoprotein profiles, adiposity and abdominal visceral fat, blood levels of steroids and other hormones, markers of oxidative stress, skeletal muscle morphology and metabolic indicators, and resting metabolic rate. These summaries document the extent of the individual differences in response to a standardized and fully monitored endurance exercise program and document the importance of familial aggregation and heritability level for exercise response traits. Findings from genomic markers, muscle gene expression studies, and proteomic and metabolomics explorations are reviewed, along with lessons learned from a bioinformatics-driven analysis pipeline. The new opportunities being pursued in integrative-omics and physiology have extended considerably the expected life of HERITAGE and are being discussed in relation to the original conceptualmodel of the study.
C1 [Sarzynski, Mark A.; Barber, Jacob L.] Univ South Carolina, Arnold Sch Publ Hlth, Dept Exercise Sci, Columbia, SC USA.
   [Rice, Treva K.; Rao, D. C.] Washington Univ, Div Biostatist, St Louis Sch Med, St Louis, MO USA.
   [Despres, Jean-Pierre; Perusse, Louis; Tremblay, Angelo] Laval Univ, Dept Kinesiol, Fac Med, Quebec City, PQ, Canada.
   [Despres, Jean-Pierre; Tchernof, Andre] Laval Univ, Quebec Heart & Lung Inst Res Ctr, Quebec City, PQ, Canada.
   [Perusse, Louis; Tremblay, Angelo] Laval Univ, Inst Nutr & Funct Foods INAF, Quebec City, PQ, Canada.
   [Stanforth, Philip R.] Univ Texas Austin, Dept Kinesiol & Hlth Educ, Austin, TX USA.
   [Tchernof, Andre] Laval Univ, Sch Nutr, Quebec City, PQ, Canada.
   [Falciani, Francesco] Univ Liverpool, Inst Syst Mol & Integrat Biol, Liverpool, England.
   [Clish, Clary] Broad Inst, Metabol Platform, Boston, MA USA.
   [Clish, Clary] Harvard Med Sch, Boston, MA USA.
   [Robbins, Jeremy M.; Gerszten, Robert E.] Beth Israel Deaconess Med Ctr, Div Cardiovasc Med, Boston, MA USA.
   [Robbins, Jeremy M.; Gerszten, Robert E.] Beth Israel Deaconess Med Ctr, Cardiovasc Res Ctr, Boston, MA USA.
   [Ghosh, Sujoy] Duke Natl Univ, Cardiovascular & Metab Disorders Program, Singapore Med Sch, Singapore, Singapore.
   [Ghosh, Sujoy] Duke Natl Univ, Ctr Computat Biol, Singapore Med Sch, Singapore, Singapore.
   [Ghosh, Sujoy; Bouchard, Claude] Pennington Biomed Res Ctr, Human Genom Lab, Baton Rouge, LA USA.
   [Leon, Arthur S.] Univ Minnesota, Sch Kinesiol, Minneapolis, MN USA.
   [Skinner, James S.] Indiana Univ, Dept Kinesiol, Bloomington, IN USA.
C3 University of South Carolina System; University of South Carolina
   Columbia; Saint Louis University; Washington University (WUSTL); Laval
   University; Quebec Heart & Lung Institute; Laval University; Laval
   University; University of Texas System; University of Texas Austin;
   Laval University; University of Liverpool; Harvard University;
   Massachusetts Institute of Technology (MIT); Broad Institute; Harvard
   University; Harvard Medical School; Harvard University; Harvard
   University Medical Affiliates; Beth Israel Deaconess Medical Center;
   Harvard University; Harvard University Medical Affiliates; Beth Israel
   Deaconess Medical Center; National University of Singapore; National
   University of Singapore; Louisiana State University System; Louisiana
   State University; Pennington Biomedical Research Center; University of
   Minnesota System; University of Minnesota Twin Cities; Indiana
   University System; Indiana University Bloomington
RP Bouchard, C (corresponding author), Pennington Biomed Res Ctr, 6400 Perkins Rd, Baton Rouge, LA 70808 USA.
EM claude.bouchard@pbrc.edu
RI Bouchard, Claude/AAE-2035-2019; Clish, Clary/AAB-7124-2019; Sarzynski,
   Mark/A-9798-2014; Barber, Jacob/AAC-1265-2022; Bouchard,
   Claude/A-7637-2009; GHOSH, SUJOY/I-3729-2017; Perusse, Louis/A-3444-2012
OI Bouchard, Claude/0000-0002-0048-491X; GHOSH, SUJOY/0000-0002-7601-165X;
   Perusse, Louis/0000-0001-6440-9698
FU National Heart, Lung and Blood Institute (NHLBI) [HL45670, HL47317,
   HL47321, HL47323, HL 47327, R01HL146462, R01NR019628, K23HL150327-02];
   National Institutes of Health (NIH) [R01HL146462, R01NR019628,
   P30GM118430, U24DK112340, U54GM115428, R01DK081572, R01DK128057, SCINBRE
   P20GM103499]; John W. Barton Sr. Chair in Genetics and Nutrition;
   Fondation de l'Universite Laval; Canadian Institutes of Health Research
   [FDN-167278]; NIGMS [U54GM104940, P20GM103528]; National Medical
   Research Council, Ministry of Health Singapore [WBS R913200076263]; John
   S. LaDue Memorial Fellowship in Cardiology at Harvard Medical School;
   Natural Sciences and Engineering Research Council of Canada; American
   Heart Association [833917]; NIH SC INBRE [P20 GM103499]; National
   Institute of Diabetes and Digestive and Kidney Diseases [R01DK081572]
   Funding Source: NIH RePORTER; NIH Office of the Director [U24DK112340]
   Funding Source: NIH RePORTER; American Heart Association (AHA) [833917]
   Funding Source: American Heart Association (AHA)
FX Thanks are expressed to the HERITAGE familieswho participated in the
   study. The authors also want to express our gratitude to all colleagues,
   research collaborators, and technical personnel who were involved in the
   planning and execution of the study. They are listed in Supplementary
   Table S3 (http://links.lww.com/MSS/C482).The authors thankMelanie
   Peterson for her support in the preparation and editing of the
   manuscript. The HERITAGE Family Study was initially funded by the
   National Heart, Lung and Blood Institute (NHLBI) through the following
   grants: HL45670 (C. Bouchard, PI) from 1992 to 2010, HL47317 (D. C. Rao,
   PI) from 1992 to 2010, HL47321 (J.H. Wilmore, PI, deceased) from 1992 to
   2003, HL47323 (A. S. Leon, PI) from 1992 to 2003, and HL 47327 (J.S.
   Skinner, PI) from 1992 to 2003. Current funding for HERITAGE is provided
   to Dr. Sarzynski (R01HL146462) and to Drs. Gerszten and Sarzynski
   (R01NR019628). Dr. Bouchard is supported by the John W. Barton Sr. Chair
   in Genetics and Nutrition and by National Institutes of Health (NIH)
   P30GM118430. Dr. Clish is supported by NIH U24DK112340. Dr. Despres is
   the ScientificDirector of the InternationalChair on Cardiometabolic Risk
   supported by the Fondation de l'Universite Laval, and he is supported by
   the Canadian Institutes of Health Research (FDN-167278). Dr. Gerszten is
   supported by NIH U54GM115428, R01DK081572, R01NR019628, and U24DK112340.
   Dr. Ghosh is supported by NIGMS U54GM104940 andP20GM103528 and the
   National Medical Research Council, Ministry of Health Singapore (WBS
   R913200076263). Dr. Robbins is supported by NHLBI K23HL150327-02 and
   John S. LaDue Memorial Fellowship in Cardiology at Harvard Medical
   School. Dr. Sarzynski is supported by NIH R01HL146462, R01NR019628,
   R01DK128057, and SCINBRE P20GM103499. Dr. Tchernof isCo-director of
   theResearchChair in Bariatric and Metabolic Surgery at Laval University.
   Dr. Tremblay is the holder of the Canada Research Chair in Environment
   and Energy Balance funded by the Natural Sciences and Engineering
   Research Council of Canada. Mr. Barber is supported byAmericanHeart
   Association Predoctoral Fellowship Award 833917 and NIH SC INBRE P20
   GM103499. HERITAGE website: Awebsite containing general information on
   the HERITAGE Family Study, including a listing of all associated
   publications, can be found at www.HeritageFamilyStudy.com.
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NR 287
TC 34
Z9 37
U1 1
U2 15
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0195-9131
EI 1530-0315
J9 MED SCI SPORT EXER
JI Med. Sci. Sports Exerc.
PD MAY
PY 2022
VL 54
IS 5
SU S
BP S1
EP S43
DI 10.1249/MSS.0000000000002859
PG 43
WC Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Sport Sciences
GA 0Y1IL
UT WOS:000790149400001
PM 35611651
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Dunstan, DW
   Kingwell, BA
   Larsen, R
   Healy, GN
   Cerin, E
   Hamilton, MT
   Shaw, JE
   Bertovic, DA
   Zimmet, PZ
   Salmon, J
   Owen, N
AF Dunstan, David W.
   Kingwell, Bronwyn A.
   Larsen, Robyn
   Healy, Genevieve N.
   Cerin, Ester
   Hamilton, Marc T.
   Shaw, Jonathan E.
   Bertovic, David A.
   Zimmet, Paul Z.
   Salmon, Jo
   Owen, Neville
TI Breaking Up Prolonged Sitting Reduces Postprandial Glucose and Insulin
   Responses
SO DIABETES CARE
LA English
DT Article; Proceedings Paper
CT Annual Conference of the
   International-Society-for-Behavioural-Nutrition-and-Physical-Activity
CY JUN 15-18, 2011
CL Melbourne, AUSTRALIA
SP Int Soc Behav Nutr & Phys Act
ID FASTING PLASMA-GLUCOSE; OXIDATIVE STRESS; PHYSICAL-ACTIVITY;
   ENERGY-EXPENDITURE; DIABETES-MELLITUS; SEDENTARY TIME; HYPERGLYCEMIA;
   EXERCISE; PREDICTOR; MORTALITY
AB OBJECTIVE-Observational studies show breaking up prolonged sitting has beneficial associations with cardiometabolic risk markers, but intervention studies are required to investigate causality. We examined the acute effects on postprandial glucose and insulin levels of uninterrupted sitting compared with sitting interrupted by brief bouts of light- or moderate-intensity walking.
   RESEARCH DESIGN AND METHODS-Overweight/obese adults (n = 19), aged 45-65 years, were recruited for a randomized three-period, three-treatment acute crossover trial: 1) uninterrupted sitting; 2) seated with 2-min bouts of light-intensity walking every 20 min; and 3) seated with 2-min bouts of moderate-intensity walking every 20 min. A standardized test drink was provided after an initial 2-h period of uninterrupted sitting. The positive incremental area under curves (iAUC) for glucose and insulin (mean [95% Cl]) for the 5 h after the test drink (75 g glucose, 50 g fat) were calculated for the respective treatments.
   RESULTS-The glucose iAUC (mmol/L) . h after both activity-break conditions was reduced (light: 5.2 [4.1-6.6]; moderate: 4.9 [3.8-6.1]; both P < 0.01) compared with uninterrupted sitting (6.9 [5.5-8.7]). insulin iAUC (pmol/L) . h was also reduced with both activity-break conditions (light: 633.6 [552.4-727.1]; moderate: 637.6 [555.5-731.9], P < 0.0001) compared with uninterrupted sitting (828.6 [722.0-950.9]).
   CONCLUSIONS-Interrupting sitting time with short bouts of light- or moderate-intensity walking lowers postprandial glucose and insulin levels in overweight/obese adults. This may improve glucose metabolism and potentially be an important public health and clinical intervention strategy for reducing cardiovascular risk.
C1 [Dunstan, David W.; Kingwell, Bronwyn A.; Larsen, Robyn; Healy, Genevieve N.; Shaw, Jonathan E.; Bertovic, David A.; Zimmet, Paul Z.; Owen, Neville] Baker IDI Heart & Diabet Inst, Melbourne, Vic, Australia.
   [Dunstan, David W.; Shaw, Jonathan E.; Zimmet, Paul Z.] Monash Univ, Dept Epidemiol & Prevent Med, Melbourne, Vic 3004, Australia.
   [Dunstan, David W.; Healy, Genevieve N.; Owen, Neville] Univ Queensland, Canc Prevent Res Ctr, Sch Populat Hlth, Brisbane, Qld, Australia.
   [Dunstan, David W.; Salmon, Jo] Deakin Univ, Sch Exercise & Nutr Sci, Melbourne, Vic, Australia.
   [Dunstan, David W.] Edith Cowan Univ, Edith Cowan Univ Hlth & Wellness Inst, Perth, WA, Australia.
   [Cerin, Ester] Univ Hong Kong, Inst Human Performance, Hong Kong, Hong Kong, Peoples R China.
   [Hamilton, Marc T.] Pennington Biomed Res Ctr, Baton Rouge, LA USA.
C3 Baker Heart and Diabetes Institute; Monash University; University of
   Queensland; Deakin University; Edith Cowan University; University of
   Hong Kong; Louisiana State University System; Louisiana State
   University; Pennington Biomedical Research Center
RP Dunstan, DW (corresponding author), Baker IDI Heart & Diabet Inst, Melbourne, Vic, Australia.
EM david.dunstan@bakeridi.edu.au
RI Kingwell, Bronwyn/B-1183-2009; Hamilton, Marc/KIC-9374-2024; Shaw,
   Jonathan/E-7388-2010; Owen, Neville/IXN-9070-2023; Larsen,
   Robyn/AAH-4137-2019; Zimmet, Paul/O-8486-2019; Salmon, Jo/X-2630-2019;
   Owen, Neville/K-5986-2012; Healy, Genevieve/A-7408-2008; /L-1271-2015;
   Salmon, Jo/C-1226-2009; Dunstan, David/E-8473-2010
OI Owen, Neville/0000-0003-2784-4820; Hamilton, Marc/0000-0003-0982-7859;
   Healy, Genevieve/0000-0001-7093-7892; Larsen, Robyn/0000-0002-4985-7211;
   Zimmet, Paul/0000-0003-0627-0776; /0000-0002-7599-165X; Salmon,
   Jo/0000-0002-4734-6354; Kingwell, Bronwyn/0000-0002-2162-0458; Dunstan,
   David/0000-0003-2629-9568
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NR 40
TC 878
Z9 999
U1 3
U2 127
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0149-5992
EI 1935-5548
J9 DIABETES CARE
JI Diabetes Care
PD MAY
PY 2012
VL 35
IS 5
BP 976
EP 983
DI 10.2337/dc11-1931
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Endocrinology & Metabolism
GA 931KN
UT WOS:000303218900009
PM 22374636
OA Green Published, hybrid, Green Submitted
DA 2025-06-11
ER

PT J
AU Goldman, DM
   Warbeck, CB
   Waterfall, TJ
   Sud, A
   Quarshie, M
   Craddock, JC
AF Goldman, David M.
   Warbeck, Cassandra B.
   Waterfall, Thomas J.
   Sud, Adam
   Quarshie, Michael
   Craddock, Joel C.
TI Plant-based and Early Time-restricted Eating for Prevention and
   Treatment of Type 2 Diabetes in Adults: A Narrative Review
SO CANADIAN JOURNAL OF DIABETES
LA English
DT Review
DE early time-restricted eating; intermittent fasting; plant-based diets;
   type 2 diabetes; vegan diets; vegetarian diets
ID DIETARY RECOMMENDATIONS; INSULIN-RESISTANCE; LOW-FAT; ASSOCIATION;
   METAANALYSIS; VEGETARIAN; NUTRITION; WEIGHT; MANAGEMENT; OXIDATION
AB Type 2 diabetes (T2D) is a significant public health challenge for which effective lifestyle interventions are needed. A growing body of evidence supports the use of both plant-based eating patterns and early time-restricted eating (eTRE) for the prevention and treatment of T2D, but research has not yet explored the potential of these dietary strategies in combination. In this narrative review, we assessed the evidence by which plant-based diets, in conjunction with eTRE, could support T2D care. The electronic databases MEDLINE and the Web of Science were searched for relevant articles published throughout the last decade. Observational research has shown that healthy plant-based eating patterns and eTRE are associated with reductions in T2D risk. Interventional trials demonstrated that plant-based diets promote improvements in glycated hemoglobin, insulin resistance, glycemic management, and cardiometabolic risk factors. These changes may be mediated, in part, by reductions in oxidative stress, dietary acid load, and hepatocellular and intramyocellular lipids. The eTRE strategies were also shown to improve insulin resistance and glycemic management, and mechanisms of action included enhanced regulation of circadian rhythm and increased metabolic flexibility. Integrating these dietary strategies may produce additive benefits, mediated by reduced visceral adiposity and beneficial shifts in gut micro biota composition. However, potential barriers to concurrent implementation of these interventions may exist, including social challenges, scheduling constraints, and tolerance. Prospective trials are needed to examine their acceptability and clinical effects. (c) 2024 Canadian Diabetes Association.
C1 [Goldman, David M.; Quarshie, Michael] Metabite Inc, New York, NY USA.
   [Warbeck, Cassandra B.] Univ Alberta, Dept Family Med, Edmonton, AB, Canada.
   [Waterfall, Thomas J.] Game Changers Inst, Laguna Niguel, CA USA.
   [Sud, Adam] Plant Based Posit Change, Austin, TX USA.
   [Craddock, Joel C.] Univ Wollongong, Sch Med Indigenous & Hlth Sci, Wollongong, NSW, Australia.
C3 University of Alberta; University of Wollongong
RP Goldman, DM (corresponding author), Metabite Inc, 43 W 43rd St,Suite 101, New York, NY 10036 USA.
EM dmg2140@tc.columbia.edu
RI Craddock, Joel/IAN-7994-2023; Goldman, David/LFV-8296-2024
OI Warbeck, Cassandra/0000-0002-0658-5009; Goldman,
   David/0009-0006-2636-9342; Waterfall, Thomas/0009-0007-5515-8488
FX D.M.G. consults for Metabite, Inc. T.J.W. consults for Game Changers
   Initiative and consults for and owns stock in FYTA and PBC. A.S. founded
   the nonprofit organization Plant-Based for Posi-tive Change, and
   consults for PlantStrong. M.Q. is employed by and owns stock in
   Metabite, Inc. C.B.W. and J.C.C. declare no conflicts of interest.
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NR 75
TC 0
Z9 0
U1 3
U2 13
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1499-2671
EI 2352-3840
J9 CAN J DIABETES
JI Can. J. Diabetes
PD JUL
PY 2024
VL 48
IS 5
AR 341e347
DI 10.1016/j.jcjd.2024.03.002
EA JUL 2024
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA ZH9Y6
UT WOS:001274535800001
PM 38513822
DA 2025-06-11
ER

PT J
AU van Deventer, CA
   Lindeque, JZ
   van Rensburg, PJJ
   Malan, L
   van der Westhuizen, FH
   Louw, R
AF van Deventer, Cynthia A.
   Lindeque, Jeremie Z.
   van Rensburg, Peet J. Jansen
   Malan, Leone
   van der Westhuizen, Francois H.
   Louw, Roan
TI Use of metabolomics to elucidate the metabolic perturbation associated
   with hypertension in a black South African male cohort: the SABPA study
SO JOURNAL OF THE AMERICAN SOCIETY OF HYPERTENSION
LA English
DT Article
DE Alcohol abuse; cardiometabolic disease; hypertension; metabolomics
ID ALCOHOL-ABUSE; S-ADENOSYLMETHIONINE; VASCULAR-DISEASE; BLOOD-PRESSURE;
   INFLAMMATION; URBAN; LIVER; MEN; URBANIZATION; POPULATION
AB There is concern about the increasing burden of essential hypertension in urban-dwelling black South Africans, especially males. Several studies have investigated urbanization and hypertension in South Africans, but in-depth metabolomics studies on these urbanized hypertensives are still lacking. We aimed to investigate hypertension via two metabolomics methods in order to explore underlying biological mechanisms, demonstrating the effectiveness of these methods in cardiovascular research. A comprehensive characterization of a group (n = 25) of black male South Africans was performed using urinary gas chromatography-mass spectrometry and liquid chromatography-mass spectrometry metabolic profiling in conjunction with 24-hour ambulatory blood pressure readings and anthropometric, clinical, and biochemical markers. Average 24-hour blood pressure readings served as the grouping variable, and test subjects were divided into quintiles. Statistical analyses were performed on Quintile 1 (normotensive subjects) and Quintile 5 (extreme hypertensive subjects). After feature selection was performed, several metabolites and cardiometabolic risk markers, including abdominal obesity and markers of liver damage, inflammation, and oxidative stress were significantly perturbed in Quintile 5 (hypertensives) compared with Quintile 1 (P < .05). Pathway analysis revealed perturbations in several systems involved in ethanol metabolism via shifted global NADH/NAD(+) ratio. Although alcohol abuse has been established as a risk factor for hypertension, this study illustrated a metabolic perturbation associated with alcohol abuse, contributing to the development of hypertension possibly by altering bioenergetics through a shift in the NADH/NAD(+) ratio. Following this finding, future intervention studies on alcohol moderation, as well as further enhancement of metabolomics methods in cardiovascular research are highly recommended. (C) 2015 American Society of Hypertension. All rights reserved.
C1 [van Deventer, Cynthia A.; Lindeque, Jeremie Z.; van Rensburg, Peet J. Jansen; van der Westhuizen, Francois H.; Louw, Roan] North West Univ, Ctr Human Metabon, ZA-2520 Potchefstroom, South Africa.
   [Malan, Leone] North West Univ, HART, ZA-2520 Potchefstroom, South Africa.
C3 North West University - South Africa; North West University - South
   Africa
RP Louw, R (corresponding author), North West Univ, Ctr Human Metabon, Potchefstroom Campus,Private Bag X6001, ZA-2520 Potchefstroom, South Africa.
EM roan.louw@nwu.ac.za
RI Lindeque, Jeremie/R-4491-2016; van Rensburg, Peet/F-9004-2010; Malan,
   Leone/Q-8187-2019; Malan, Leone/D-7203-2014; van der Westhuizen,
   Francois/E-6959-2011
OI Louw, Roan/0000-0002-6542-8644; Lindeque, Zander/0000-0001-8017-4278;
   Malan, Leone/0000-0003-3187-2410; van der Westhuizen,
   Francois/0000-0002-7879-1776; Jansen van Rensburg, Peet
   J/0000-0001-6911-1866
FU North-West University (Potchefstroom campus); North-West Department of
   Education; National Research Foundation; Medical Research Council; ROCHE
   Diagnostics, South Africa; Technology Innovation Agency (TIA); Metabolic
   Syndrome Institute, France
FX Funding grants for this study were obtained from the North-West
   University (Potchefstroom campus); North-West Department of Education;
   the National Research Foundation; Medical Research Council; ROCHE
   Diagnostics, South Africa, the Biotechnology Partnerships and
   Development (BIOPAD), now called the Technology Innovation Agency (TIA),
   and the Metabolic Syndrome Institute, France. The funding organizations
   played no role in the design and conduct of the study; collection,
   management, analysis and interpretation of the data; preparation,
   review, or approval of the manuscript.
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NR 58
TC 30
Z9 30
U1 2
U2 13
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1933-1711
EI 1878-7436
J9 J AM SOC HYPERTENS
JI J. Am. Soc. Hypertens.
PD FEB
PY 2015
VL 9
IS 2
BP 104
EP 114
DI 10.1016/j.jash.2014.11.007
PG 11
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA CD6HA
UT WOS:000351189000004
PM 25577962
DA 2025-06-11
ER

PT J
AU Gioiosa, L
   Palanza, P
   Parmigiani, S
   vom Saal, FS
AF Gioiosa, Laura
   Palanza, Paola
   Parmigiani, Stefano
   vom Saal, Frederick S.
TI Risk Evaluation of Endocrine-Disrupting Chemicals: Effects of
   Developmental Exposure to Low Doses of Bisphenol A on Behavior and
   Physiology in Mice (Mus musculus)
SO DOSE-RESPONSE
LA English
DT Review
DE endocrine disrupters; animal model; prenatal and postnatal exposure; sex
   differences; behavior; metabolism
ID CONSENSUS STATEMENT; METABOLIC SYNDROME; SEX-DIFFERENCES; PUBLIC-HEALTH;
   BODY-WEIGHT; URINARY; ASSOCIATION; RESPONSES; OBESITY; BPA
AB We review here our studies on early exposure to low doses of the estrogenic endocrine-disrupting chemical bisphenol A (BPA) on behavior and metabolism in CD-1 mice. Mice were exposed in utero from gestation day (GD) 11 to delivery (prenatal exposure) or via maternal milk from birth to postnatal day 7 (postnatal exposure) to 10 mu g/kg body weight/d of BPA or no BPA (controls). Bisphenol A exposure resulted in long-term disruption of sexually dimorphic behaviors. Females exposed to BPA pre- and postnatally showed increased anxiety and behavioral profiles similar to control males. We also evaluated metabolic effects in prenatally exposed adult male offspring of dams fed (from GD 9 to 18) with BPA at doses ranging from 5 to 50 000 mu g/kg/d. The males showed an age-related significant change in a number of metabolic indexes ranging from food intake to glucose regulation at BPA doses below the no observed adverse effect level (5000 mu g/kg/d). Consistent with prior findings, low but not high BPA doses produced significant effects for many outcomes. These findings provide further evidence of the potential risks that developmental exposure to low doses of the endocrine disrupter BPA may pose to human health, with fetuses and infants being highly vulnerable.
C1 [Gioiosa, Laura; Palanza, Paola; Parmigiani, Stefano] Univ Parma, Dept Neurosci, Behav Biol Unit, I-43124 Parma, Italy.
   [vom Saal, Frederick S.] Univ Missouri, Div Biol Sci, Columbia, MO 65211 USA.
C3 University of Parma; University of Missouri System; University of
   Missouri Columbia
RP Parmigiani, S (corresponding author), Univ Parma, Dept Neurosci, Behav Biol Unit, Viale Sci 11-A, I-43124 Parma, Italy.
EM stefano.parmigiani@unipr.it
RI GIOIOSA, Laura/LGZ-8917-2024
OI GIOIOSA, Laura/0000-0002-8334-863X
FU NIEHS [ES021394]; University of Parma; MIUR [PRIN 20107MSMA4_005]
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: Support to
   FvS is from NIEHS, ES021394; Support to PP, LG and SP is from University
   of Parma and MIUR, PRIN 20107MSMA4_005.
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NR 56
TC 33
Z9 37
U1 0
U2 23
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1559-3258
J9 DOSE-RESPONSE
JI Dose-Response
PD OCT-DEC
PY 2015
VL 13
IS 4
DI 10.1177/1559325815610760
PG 8
WC Pharmacology & Pharmacy; Radiology, Nuclear Medicine & Medical Imaging;
   Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Radiology, Nuclear Medicine & Medical Imaging;
   Toxicology
GA DA0IS
UT WOS:000367481400003
PM 26740806
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Roh, YS
   Huang, AH
   Sutaria, N
   Choi, U
   Wongvibulsin, S
   Choi, J
   Bordeaux, ZA
   Parthasarathy, V
   Deng, J
   Patel, DP
   Canner, JK
   Grossberg, AL
   Kwatra, SG
AF Roh, Youkyung S.
   Huang, Amy H.
   Sutaria, Nishadh
   Choi, Una
   Wongvibulsin, Shannon
   Choi, Justin
   Bordeaux, Zachary A.
   Parthasarathy, Varsha
   Deng, Junwen
   Patel, Deepa P.
   Canner, Joseph K.
   Grossberg, Anna L.
   Kwatra, Shawn G.
TI Real-world comorbidities of atopic dermatitis in the US adult ambulatory
   population
SO JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
LA English
DT Article
DE atopic dermatitis; comorbidities; eczema; epidemiology; itch;
   MarketScan; pruritus
ID AUTOIMMUNE-DISEASES; SLEEP DISTURBANCE; SKIN-DISEASE; PREVALENCE; RISK;
   ASSOCIATION; INFECTIONS; HEALTH; IMPACT; CANCER
AB Background: Atopic dermatitis (AD) is a pruritic, inflammatory skin disease associated with various comorbidities. However, comprehensive analyses of real-world comorbidities in adult patients with AD are limited.
   Objective: To characterize the real-world comorbidities associated with adult AD in an ambulatory population.
   Methods: We queried the MarketScan Commercial Claims and Encounters database from January 1, 2017 to December 31, 2017. Multivariable logistic regressions were performed to compare comorbidities in adult patients with AD versus age- and sex-matched controls.
   Results: A total of 39,779 patients with AD and 353,743 controls were identified. Increased odds of psychiatric conditions, including anxiety (odds ratio [OR] 1.44) and mood disorders (OR 1.31), were observed in patients with AD. Patients with AD had higher likelihoods of autoimmune diseases, including vitiligo (OR 4.44) and alopecia areata (OR 6.01). Adult AD was also associated with infections, including impetigo (OR 9.72), methicillin-resistant Staphylococcus aureus (OR 3.92), and cellulitis (OR 2.52). Patients with AD were more likely to have systemic conditions, including lymphoid/hematopoietic malignancy (OR 1.91), atherosclerosis (OR 1.69), and metabolic syndrome (OR 1.47). For all the above, P < .001.
   Limitations: Retrospective analysis of health care claims data.
   Conclusion: Adult AD is associated with various psychiatric and systemic comorbidities, emphasizing the systemic nature of AD and the need for the collaborative management of these patients.
C1 [Roh, Youkyung S.; Huang, Amy H.; Sutaria, Nishadh; Choi, Una; Wongvibulsin, Shannon; Choi, Justin; Bordeaux, Zachary A.; Parthasarathy, Varsha; Patel, Deepa P.; Grossberg, Anna L.; Kwatra, Shawn G.] Johns Hopkins Univ, Sch Med, Dept Dermatol, Canc Res Bldg 2,Suite 206,1550 Orleans St, Baltimore, MD 21231 USA.
   [Huang, Amy H.; Kwatra, Shawn G.] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Baltimore, MD 21231 USA.
   [Deng, Junwen] Albert Einstein Coll Med, Dept Dermatol, Bronx, NY 10467 USA.
   [Canner, Joseph K.] Johns Hopkins Univ, Sch Med, Johns Hopkins Surg Ctr Outcomes Res, Dept Surg, Baltimore, MD 21231 USA.
C3 Johns Hopkins University; Johns Hopkins University; Johns Hopkins
   Bloomberg School of Public Health; Montefiore Medical Center; Albert
   Einstein College of Medicine; Yeshiva University; Johns Hopkins
   University
RP Kwatra, SG (corresponding author), Johns Hopkins Univ, Sch Med, Dept Dermatol, Canc Res Bldg 2,Suite 206,1550 Orleans St, Baltimore, MD 21231 USA.
EM skwatra1@jhmi.edu
OI Wongvibulsin, Shannon/0000-0002-1390-7440
FU Pfizer Inc.
FX Dr Kwatra received grant funding from Pfizer Inc.
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NR 59
TC 29
Z9 30
U1 0
U2 4
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0190-9622
EI 1097-6787
J9 J AM ACAD DERMATOL
JI J. Am. Acad. Dermatol.
PD APR
PY 2022
VL 86
IS 4
BP 835
EP 845
DI 10.1016/j.jaad.2021.11.014
EA MAR 2022
PG 11
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 3T4TD
UT WOS:000840267700018
PM 34800600
DA 2025-06-11
ER

PT J
AU Nishi, D
   Suzuki, Y
   Nishida, J
   Mishima, K
   Yamanouchi, Y
AF Nishi, Daisuke
   Suzuki, Yuriko
   Nishida, Junko
   Mishima, Kazuo
   Yamanouchi, Yoshio
TI Personal lifestyle as a resource for work engagement
SO JOURNAL OF OCCUPATIONAL HEALTH
LA English
DT Article
DE Dietary intake of fish; Exercise; Lifestyle; Sleep; Tobacco use; Work
   engagement
ID JAPANESE COMPANY WORKERS; DEPRESSIVE SYMPTOMS; PHYSICAL-ACTIVITY; FISH
   CONSUMPTION; SHORT QUESTIONNAIRE; MENTAL-DISORDERS; SCREENING SCALES;
   JOB RESOURCES; LEISURE-TIME; METAANALYSIS
AB Objectives: Personal lifestyle, including diet, exercise, and sleep, might have an impact on work engagement, though previous studies have not focused on these relationships. The aim of this study was to examine whether dietary intake of fish, regular exercise, sufficient sleep, abstinence from alcohol, and abstinence from tobacco were positively associated with work engagement. Methods: We recruited adults aged 40-74 years who attended the health checkups with a particular focus on the metabolic syndrome in central Tokyo. In December 2015, 797 people responded to a questionnaire and 592 (74.3%) who had regular jobs were selected for this study. Work engagement was assessed on the 9-item Utrecht Work Engagement Scale (UWES-9). Bivariate and multivariate regression analyses were performed to examine the relationships between lifestyle and UWES-9. Results: Dietary intake of fish, regular exercise, sufficient sleep, and abstinence from tobacco were significantly correlated with the total UWES-9 score, even after adjusting for age, sex, and depressive and anxiety symptoms. The results suggested a doseresponse relationship between dietary fish intake and work engagement. Conclusions : Dietary fish intake, regular exercise, sufficient sleep, and abstinence from tobacco might be lifestyle factors that can serve as resources for work engagement. These findings could be useful in motivating employees to make lifestyle improvements and convincing employers and managers that lifestyle is important not only for health but also for productivity.
C1 [Nishi, Daisuke; Yamanouchi, Yoshio] Natl Ctr Neurol & Psychiat, Natl Inst Mental Hlth, Dept Mental Hlth Policy & Evaluat, Kodaira, Tokyo, Japan.
   [Nishi, Daisuke] Univ Tokyo, Grad Sch Med, Dept Publ Mental Hlth Policy, Tokyo, Japan.
   [Suzuki, Yuriko] Natl Ctr Neurol & Psychiat, Natl Inst Mental Hlth, Dept Adult Mental Hlth, Kodaira, Tokyo, Japan.
   [Nishida, Junko] Tokyo Yamate Med Ctr, Shinjuku Ku, Tokyo, Japan.
   [Mishima, Kazuo] Natl Ctr Neurol & Psychiat, Natl Inst Mental Hlth, Dept Psychophysiol, Kodaira, Tokyo, Japan.
C3 National Center for Neurology & Psychiatry - Japan; University of Tokyo;
   National Center for Neurology & Psychiatry - Japan; National Center for
   Neurology & Psychiatry - Japan
RP Nishi, D (corresponding author), Natl Ctr Neurol & Psychiat, Natl Inst Mental Hlth, 4-1-1 Ogawahigashicyo, Kodaira, Tokyo 1878553, Japan.
EM d-nishi@umin.ac.jp
RI Nishi, Daisuke/AAH-7211-2019
OI Nishi, Daisuke/0000-0001-9349-3294; MISHIMA, KAZUO/0000-0003-1182-1181
FU Health Labour Sciences Research Grant from the Ministry of Health,
   Labour and Welfare
FX The study was supported by a Health Labour Sciences Research Grant from
   the Ministry of Health, Labour and Welfare. We thank Mss. Emiko Anazawa
   and Mieko Narita for data management. None of the acknowledged
   individuals report any financial or other conflicts of interest related
   to the subject of this work.
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NR 36
TC 26
Z9 26
U1 0
U2 22
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1341-9145
EI 1348-9585
J9 J OCCUP HEALTH
JI J. Occup. Health
PD JAN
PY 2017
VL 59
IS 1
BP 17
EP 23
DI 10.1539/joh.16-0167-OA
PG 7
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA EJ2HN
UT WOS:000393030800003
PM 27885245
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Bhatt, IS
   Garay, JAR
   Bhagavan, SG
   Ingalls, V
   Dias, R
   Torkamani, A
AF Bhatt, Ishan Sunilkumar
   Garay, Juan Antonio Raygoza
   Bhagavan, Srividya Grama
   Ingalls, Valerie
   Dias, Raquel
   Torkamani, Ali
TI Polygenic Risk Score-Based Association Analysis Identifies Genetic
   Comorbidities Associated with Age-Related Hearing Difficulty in Two
   Independent Samples
SO JARO-JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY
LA English
DT Article
DE Polygenic risk scores; Age-related hearing difficulty; Age-related
   hearing loss; Presbycusis; Hearing loss; Extended-high frequency
   audiometry; Distortion-product otoacoustic emissions
ID GENOME-WIDE ASSOCIATION; PLASMA PROTEIN-A; METABOLIC SYNDROME; PAPP-A;
   HYPOTENSION; PREDICTOR; DISEASE; ADULTS; IRON
AB Purpose Age-related hearing loss is the most common form of permanent hearing loss that is associated with various health traits, including Alzheimer's disease, cognitive decline, and depression. The present study aims to identify genetic comorbidities of age-related hearing loss. Past genome-wide association studies identified multiple genomic loci involved in common adult-onset health traits. Polygenic risk scores (PRS) could summarize the polygenic inheritance and quantify the genetic susceptibility of complex traits independent of trait expression. The present study conducted a PRS-based association analysis of age-related hearing difficulty in the UK Biobank sample (N = 425,240), followed by a replication analysis using hearing thresholds (HTs) and distortion-product otoacoustic emissions (DPOAEs) in 242 young adults with self-reported normal hearing. We hypothesized that young adults with genetic comorbidities associated with age-related hearing difficulty would exhibit subclinical decline in HTs and DPOAEs in both ears. Methods A total of 111,243 participants reported age-related hearing difficulty in the UK Biobank sample (> 40 years). The PRS models were derived from the polygenic risk score catalog to obtain 2627 PRS predictors across the health spectrum. HTs (0.25-16 kHz) and DPOAEs (1-16 kHz, L1/L2 = 65/55 dB SPL, F2/F1 = 1.22) were measured on 242 young adults. Saliva-derived DNA samples were subjected to low-pass whole genome sequencing, followed by genome-wide imputation and PRS calculation. The logistic regression analyses were performed to identify PRS predictors of age-related hearing difficulty in the UK Biobank cohort. The linear mixed model analyses were performed to identify PRS predictors of HTs and DPOAEs. Results The PRS-based association analysis identified 977 PRS predictors across the health spectrum associated with age-related hearing difficulty. Hearing difficulty and hearing aid use PRS predictors revealed the strongest association with the age-related hearing difficulty phenotype. Youth with a higher genetic predisposition to hearing difficulty revealed a subclinical elevation in HTs and a decline in DPOAEs in both ears. PRS predictors associated with age-related hearing difficulty were enriched for mental health, lifestyle, metabolic, sleep, reproductive, digestive, respiratory, hematopoietic, and immune traits. Fifty PRS predictors belonging to various trait categories were replicated for HTs and DPOAEs in both ears. Conclusion The study identified genetic comorbidities associated with age-related hearing loss across the health spectrum. Youth with a high genetic predisposition to age-related hearing difficulty and other related complex traits could exhibit sub-clinical decline in HTs and DPOAEs decades before clinically meaningful age-related hearing loss is observed. We posit that effective communication of genetic risk, promoting a healthy lifestyle, and reducing exposure to environmental risk factors at younger ages could help prevent or delay the onset of age-related hearing difficulty at older ages.
C1 [Bhatt, Ishan Sunilkumar; Garay, Juan Antonio Raygoza; Bhagavan, Srividya Grama; Ingalls, Valerie] Univ Iowa, Dept Commun Sci & Disorders, 250 Hawkins Dr, Iowa City, IA 52242 USA.
   [Garay, Juan Antonio Raygoza] Univ Iowa, Holden Comprehens Canc Ctr, Iowa City, IA 52242 USA.
   [Dias, Raquel] Univ Florida, Dept Microbiol & Cell Sci, Gainesville, FL 32608 USA.
   [Torkamani, Ali] Scripps Res Inst, Dept Integrat Struct & Computat Biol, La Jolla, CA 92037 USA.
C3 University of Iowa; University of Iowa; State University System of
   Florida; University of Florida; Scripps Research Institute
RP Bhatt, IS (corresponding author), Univ Iowa, Dept Commun Sci & Disorders, 250 Hawkins Dr, Iowa City, IA 52242 USA.
EM Ishan-Bhatt@uiowa.edu; jraygozagaray@uiowa.edu;
   srividya-gramabhagavan@uiowa.edu; valerie-ingalls@uiowa.edu;
   raquel.dias@ufl.edu; atorkama@scripps.edu
RI Garay, Juan/AAM-9568-2021; Dias, Raquel/NDS-1897-2025
OI Raygoza Garay, Juan Antonio/0000-0003-4296-4118
FU National Institute on Deafness and Other Communication Disorders
FX No Statement Available
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NR 82
TC 0
Z9 0
U1 4
U2 4
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1525-3961
EI 1438-7573
J9 JARO-J ASSOC RES OTO
JI JARO
PD AUG
PY 2024
VL 25
IS 4
BP 387
EP 406
DI 10.1007/s10162-024-00947-0
EA MAY 2024
PG 20
WC Neurosciences; Otorhinolaryngology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Otorhinolaryngology
GA E0N8K
UT WOS:001230113900001
PM 38782831
DA 2025-06-11
ER

PT J
AU Joseph, JJ
   Wang, X
   Roux, AVD
   Sanchez, BN
   Seeman, TE
   Needham, BL
   Golden, SH
AF Joseph, Joshua J.
   Wang, Xu
   Roux, Ana V. Diez
   Sanchez, Brisa N.
   Seeman, Teresa E.
   Needham, Belinda L.
   Golden, Sherita Hill
TI Antecedent longitudinal changes in body mass index are associated with
   diurnal cortisol curve features: The multi-ethnic study of
   atherosclerosis
SO METABOLISM-CLINICAL AND EXPERIMENTAL
LA English
DT Article
DE Cortisol; Waist circumference; Body mass index; Obesity;
   Hypothalamic-Pituitary-Adrenal axis
ID SALIVARY CORTISOL; METABOLIC SYNDROME; ABDOMINAL OBESITY;
   CARDIOVASCULAR-DISEASE; INSULIN-RESISTANCE; MEN; SECRETION; STRESS;
   RESTRICTION; PATTERNS
AB Context. Prior studies have shown a cross-sectional association between body mass index (BMI) and salivary diurnal cortisol profile features (cortisol features); however, to our knowledge prior population-based studies have not examined the longitudinal association of body-mass index (BMI) with cortisol features.
   Objective. To examine the association of (1) prior annual BMI percent change over 7 years with cortisol features, (2) baseline cortisol features with subsequent change in BMI over 6 years and (3) the association of change in cortisol features with change in BMI over 6 years.
   Design. Longitudinal study.
   Setting. Multi-Ethnic Study of Atherosclerosis (MESA) Stress I & II Studies (2004-2006 & 2010-2012).
   Participants. 1685 ethnically diverse men and women attended either MESA Stress exam (mean age 65 10 years at MESA Stress I; mean age 69 9 years at MESA Stress II).
   Outcome Measures. Log-transformed cortisol features including wake-up cortisol, cortisol awakening response, early decline slope (30 min to 2 h post-awakening), late decline slope (2 h post-awakening to bedtime), bedtime, and total area under the curve (AUC) cortisol.
   Results. Over 7 years, following multivariable adjustment, (1) a 1% higher prior annual BMI % increase was associated with a 2.9% (95% CI: -5.0%, -0.8%) and 3.0% (95% CI: -4.7%, -1.4%) lower current wake-up and total AUC cortisol, respectively; (2) there was no significant association between baseline cortisol features and subsequent change in BMI and (3) among participants with BMI >= 30 kg/m(2), flattening of the late decline slope was associated with increases in BMI (every 1-unit increase late decline slope were associated with a 12.9% increase (95%CI: -1%, 26.8%) in BMI, respectively).
   Conclusions. We found a significant association between prior annual BMI % change and cortisol features, but no significant association between baseline cortisol features and subsequent change in BMI. In participants with obesity increases in BMI were associated with less pronounced declined. Collectively, our results suggest that greater adiposity may lead to a blunted diurnal cortisol profile. (C) 2016 Elsevier Inc. All rights reserved.
C1 [Joseph, Joshua J.; Golden, Sherita Hill] Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21205 USA.
   [Joseph, Joshua J.] Ohio State Univ, Wexner Med Ctr, Dept Med, 566 McCampbell Hall,1581 Dodd Dr, Columbus, OH 43210 USA.
   [Wang, Xu; Roux, Ana V. Diez] Drexel Univ, Sch Publ Hlth, Philadelphia, PA 19104 USA.
   [Sanchez, Brisa N.] Univ Michigan, Dept Biostat, Ann Arbor, MI 48109 USA.
   [Seeman, Teresa E.] Univ Calif Los Angeles, David Geffen Sch Med, Div Geriatr, Los Angeles, CA 90095 USA.
   [Needham, Belinda L.] Univ Michigan, Dept Epidemiol, Ann Arbor, MI 48109 USA.
   [Golden, Sherita Hill] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA.
C3 Johns Hopkins University; University System of Ohio; Ohio State
   University; Drexel University; University of Michigan System; University
   of Michigan; University of California System; University of California
   Los Angeles; University of California Los Angeles Medical Center; David
   Geffen School of Medicine at UCLA; University of Michigan System;
   University of Michigan; Johns Hopkins University; Johns Hopkins
   Bloomberg School of Public Health
RP Joseph, JJ (corresponding author), Ohio State Univ, Wexner Med Ctr, Dept Med, 566 McCampbell Hall,1581 Dodd Dr, Columbus, OH 43210 USA.
EM joseph.117@osu.edu
RI Joseph, Joshua/NDR-8695-2025
OI Joseph, Joshua/0000-0001-9169-8261; Sanchez, Brisa/0000-0002-4824-7200;
   Needham, Belinda/0000-0001-5939-2027
FU National Heart, Lung, and Blood Institute [HHSN268201500003I,
   N01-HC-95159, N01-HC-95169]; NCRR [UL1-TR-000040, UL1-TR-001079];
   National Institute of Diabetes, Digestive, and Kidney Diseases [T32
   DK062707];  [RO1 HL10161-01A1];  [R21 DA024273]
FX This research was supported by contracts HHSN268201500003I, N01-HC-95159
   through N01-HC-95169 from the National Heart, Lung, and Blood Institute
   and by grants UL1-TR-000040 and UL1-TR-001079 from NCRR. MESA Stress
   Study was supported by RO1 HL10161-01A1 and R21 DA024273 (PI: Dr. Diez
   Roux). Dr. Joshua J. Joseph MD was supported by an institutional
   training grant from the National Institute of Diabetes, Digestive, and
   Kidney Diseases (T32 DK062707).
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NR 48
TC 19
Z9 21
U1 0
U2 6
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0026-0495
EI 1532-8600
J9 METABOLISM
JI Metab.-Clin. Exp.
PD MAR
PY 2017
VL 68
BP 95
EP 107
DI 10.1016/j.metabol.2016.12.001
PG 13
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA EK4WF
UT WOS:000393927600010
PM 28183457
OA Green Accepted, Green Submitted
DA 2025-06-11
ER

PT J
AU Menini, S
   Iacobini, C
   Ricci, C
   Oddi, G
   Pesce, C
   Pugliese, F
   Block, K
   Abboud, HE
   Giorgio, M
   Migliaccio, E
   Pelicci, PG
   Pugliese, G
AF Menini, S.
   Iacobini, C.
   Ricci, C.
   Oddi, G.
   Pesce, C.
   Pugliese, F.
   Block, K.
   Abboud, H. E.
   Giorgio, M.
   Migliaccio, E.
   Pelicci, P. G.
   Pugliese, G.
TI Ablation of the gene encoding p66<SUP>Shc</SUP> protects mice against
   AGE-induced glomerulopathy by preventing oxidant-dependent tissue injury
   and further AGE accumulation
SO DIABETOLOGIA
LA English
DT Article
DE AGEs; AGE receptors; apoptosis; extracellular matrix; nephropathy;
   oxidative stress; p66(Shc); NAD(P)H oxidase; NOX4; Nuclear factor kappa
   B
ID GLYCATION END-PRODUCTS; ENDOTHELIAL GROWTH-FACTOR; HIGH-FAT DIET;
   NF-KAPPA-B; OXIDATIVE STRESS; DIABETIC COMPLICATIONS; METABOLIC
   SYNDROME; SIGNALING PATHWAY; HINDLIMB ISCHEMIA; INDUCED APOPTOSIS
AB Aims/hypothesis AGEs have been implicated in renal disease associated with ageing, diabetes and other age-related disorders. Reactive oxygen species (ROS) promote formation of AGEs, which cause AGE-receptor-mediated ROS generation with activation of signalling pathways leading to tissue injury and further AGE accumulation. ROS generation is regulated by the Src homology 2 domain-containing transforming protein C1 (Shc1) isoform p66(Shc), whose deletion has been shown to protect from tissue injury induced by ageing, diabetes, hyperlipidaemia and ischaemia-reperfusion by preventing oxidative stress. This study was aimed at assessing the role of p66(Shc) in the modulation of oxidative stress and oxidant-dependent renal injury induced by AGEs.
   Methods For 10 weeks, male p66 (shc) knockout (KO) and wild-type (WT) mice were injected with 60 mu g/day albumin modified or unmodified by N (epsilon)(carboxymethyl) lysine (CML). Mice were then killed for the assessment of renal function and structure, as well as systemic and renal tissue oxidative stress.
   Results Upon CML injection, KO mice, in contrast to WT mice, showed no or only mild forms of proteinuria, glomerular hypertrophy, mesangial expansion, glomerular sclerosis, renal/glomerular cell apoptosis and extracellular matrix upregulation. Moreover, KO mice had lower circulating and tissue AGEs than WT mice and unchanged plasma isoprostane 8-epi-prostaglandin-F-2 alpha levels, renal/glomerular CML, 4-hydroxy-2-nonenal, AGE receptor and NAD(P)H oxidase 4 (NOX4) content (and expression of the corresponding genes), and nuclear factor kappa B activation (NF kappa B). Mesangial cells from KO mice exposed to CML showed no or slight increase in ROS levels and NF kappa B activation, again at variance with WT cells.
   Conclusions/interpretation These data indicate that p66(Shc) participates in the pathogenesis of AGE-dependent glomerulopathy by mediating AGE-induced tissue injury and further AGE formation through ROS-dependent mechanisms involving NF kappa B activation and upregulation of Nox4 expression and NOX4 production.
C1 Univ Roma La Sapienza, Dept Clin Sci, I-00161 Rome, Italy.
   Univ Genoa, Sch Med, DISTBIMO, Genoa, Italy.
   Univ Texas, Hlth Sci Ctr, Dept Med, Div Nephrol, San Antonio, TX 78284 USA.
   European Inst Oncol, Dept Expt Oncol, Milan, Italy.
C3 Sapienza University Rome; University of Genoa; University of Texas
   System; University of Texas Health Science Center at San Antonio; IRCCS
   European Institute of Oncology (IEO)
RP Pugliese, G (corresponding author), Univ Roma La Sapienza, Dept Clin Sci, Via Policlin, I-00161 Rome, Italy.
EM giuseppe.pugliese@uniroma1.it
RI Pelicci, Pier/AAL-6572-2020; Migliaccio, Enrica/AAQ-8880-2020; Giorgio,
   Marco/I-9425-2012; Pugliese, Giuseppe/G-8776-2012; Menini,
   Stefano/G-1130-2010
OI , Enrica Migliaccio/0000-0002-3989-8773; Pugliese,
   Giuseppe/0000-0003-1574-0397; Menini, Stefano/0000-0001-7328-2385;
   PELICCI, PIER GIUSEPPE/0000-0002-5076-2316
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NR 50
TC 59
Z9 68
U1 0
U2 3
PU SPRINGER
PI NEW YORK
PA 233 SPRING STREET, NEW YORK, NY 10013 USA
SN 0012-186X
J9 DIABETOLOGIA
JI Diabetologia
PD SEP
PY 2007
VL 50
IS 9
BP 1997
EP 2007
DI 10.1007/s00125-007-0728-7
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 200OD
UT WOS:000248771800025
PM 17611735
OA Bronze
DA 2025-06-11
ER

PT J
AU Kothawade, K
   Bairey, CN
AF Kothawade, Kamlesh
   Bairey, C. Noel
TI Microvascular Coronary Dysfunction in Women-Pathophysiology, Diagnosis,
   and Management
SO CURRENT PROBLEMS IN CARDIOLOGY
LA English
DT Review
ID MYOCARDIAL BLOOD-FLOW; CARDIAC SYNDROME-X; CARDIOVASCULAR
   MAGNETIC-RESONANCE; CHEST-PAIN; ENDOTHELIAL DYSFUNCTION;
   ANGINA-PECTORIS; ARTERY-DISEASE; NATIONAL-HEART; HYPERTENSIVE PATIENTS;
   VASODILATOR RESERVE
AB Women exhibit a greater symptom burden, more functional disability, and a higher prevalence of no obstructive coronary artery disease compared to men when evaluated for signs and symptoms of myocardial ischemia. Microvascular coronary dysfunction (MCD), defined as limited coronary flow reserve and/or coronary endothelial dysfunction, is the predominant etiologic mechanism of ischemia in women with the triad of persistent chest pain, no obstructive coronary artery disease, and ischemia evidenced by stress testing. Evidence shows that approximately 50% of these patients have physiological evidence of MCD. MCD is associated with a 2.5% annual major adverse event rate that includes death, nonfatal myocardial infarction, nonfatal stroke, and congestive heart failure. Although tests such as adenosine stress cardiac magnetic resonance imaging may be a useful noninvasive method to predict subendocardial ischemia, the gold standard test to diagnose MCD is an invasive coronary reactivity testing. Early identification of MCD by coronary reactivity testing may be beneficial in prognostication and stratifying these patients for optimal medical therapy. Currently, understanding of MCD pathophysiology can be used to guide diagnosis and therapy. Continued research in MCD is needed to further advance our understanding. (Curr Probl Cardiol 2011;36:291-318.)
C1 [Bairey, C. Noel] Cedars Sinai Med Ctr, Womens Heart Ctr, New York, NY USA.
   [Bairey, C. Noel] Cedars Sinai Med Ctr, Prevent & Rehabilitat Cardiac Ctr, New York, NY USA.
C3 Cedars Sinai Medical Center; Cedars Sinai Medical Center
OI Bairey Merz, C. Noel/0000-0002-9933-5155
FU National Heart, Lung and Blood Institutes [N01-HV-68161, N01-HV-68162,
   N01-HV-68163, N01-HV-68164]; National Center for Research Resources
   [M01-RR00425]; Gustavus and Louis Pfeiffer Research Foundation,
   Denville, NJ; Women's Guild of Cedars-Sinai Medical Center, Los Angeles,
   CA; Ladies Hospital Aid Society of Western Pennsylvania, Pittsburgh, PA;
   Cedars-Sinai Medical Center, Los Angeles, CA
FX This work was supported by contracts from the National Heart, Lung and
   Blood Institutes, Nos. N01-HV-68161, N01-HV-68162, N01-HV-68163,
   N01-HV-68164, a GCRC Grant M01-RR00425 from the National Center for
   Research Resources, and grants from the Gustavus and Louis Pfeiffer
   Research Foundation, Denville, NJ, The Women's Guild of Cedars-Sinai
   Medical Center, Los Angeles, CA, and The Ladies Hospital Aid Society of
   Western Pennsylvania, Pittsburgh, PA; the Edythe L. Broad Women's Heart
   Research Fellowship, Cedars-Sinai Medical Center, Los Angeles, CA; and
   the Barbra Streisand Women's Cardiovascular Research and Education
   Program, Cedars-Sinai Medical Center, Los Angeles, CA.
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NR 111
TC 93
Z9 99
U1 1
U2 9
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0146-2806
EI 1535-6280
J9 CURR PROB CARDIOLOGY
JI Curr. Probl. Cardiol.
PD AUG
PY 2011
VL 36
IS 8
BP 291
EP 318
DI 10.1016/j.cpcardiol.2011.05.002
PG 28
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 790XA
UT WOS:000292622900002
PM 21723447
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Sokary, S
   Bawadi, H
   Zakaria, ZZ
   Al-Asmakh, M
AF Sokary, Sara
   Bawadi, Hiba
   Zakaria, Zain Zaki
   Al-Asmakh, Maha
TI The Effects of Spirulina Supplementation on Cardiometabolic Risk
   Factors: A Narrative Review
SO JOURNAL OF DIETARY SUPPLEMENTS
LA English
DT Review
DE Body weight; cardiometabolic diseases; glucose metabolism; inflammation;
   lipid profile; spirulina
ID ARTHROSPIRA-PLATENSIS SUPPLEMENTATION; LIPID PROFILE; CRETAN POPULATION;
   OXIDATIVE STRESS; DOUBLE-BLIND; OBESITY; PHYCOCYANOBILIN; METAANALYSIS;
   DISEASE; IMPACT
AB Spirulina (Arthrospira platensis) is a cyanobacterium associated with multiple health benefits. Cardiometabolic diseases such as cardiovascular disease, nonalcoholic fatty liver disease, and diabetes are prevalent yet usually preventable non-communicable diseases. Modifiable risk factors for cardiometabolic diseases include excessive body weight, body inflammation, atherogenic lipid profile, and imbalanced glucose metabolism. This review explores the effects of spirulina on cardiometabolic diseases risk factors. Spirulina was effective in reducing body weight, body mass index, and waist circumference, with a potential dose-dependent effect. It also decreased interleukin 6, an important biomarker of body inflammation, by inhibiting NADPH oxidase enzyme, and lowering insulin resistance. spirulina supplementation also reduced triglycerides, low-density lipoprotein cholesterol, and increased high-density lipoprotein cholesterol. Additionally, spirulina reduced fasting blood sugar and post-prandial blood sugar and increased insulin sensitivity, but no effect was observed on glycated hemoglobin A1c. The diverse nutrients, such as phycocyanin, gamma-linolenic acid, and vitamin B12, present in spirulina contribute to its cardiometabolic benefits. The doses used are heterogeneous for most studies, ranging from 1 to 8 grams daily, but most studies administered spirulina for 3 months to observe an effect. The collective evidence suggests that spirulina supplements may help improve risk factors for cardiometabolic diseases, thus, preventing its development. However, due to the heterogeneity of the results, more randomized clinical trials are needed to draw robust conclusions about spirulina's therapeutic potential in ameliorating risk factors for cardiometabolic diseases and fully elucidate the mechanisms by which it exerts its effects.
C1 [Sokary, Sara; Bawadi, Hiba] Qatar Univ, QU Hlth, Coll Hlth Sci, Dept Human Nutr, Doha, Qatar.
   [Zakaria, Zain Zaki] Qatar Univ, Hlth Cluster, Med & Hlth Sci off, Doha, Qatar.
   [Al-Asmakh, Maha] Qatar Univ, QU Hlth, Coll Hlth Sci, Dept Biomed Sci, Doha, Qatar.
   [Al-Asmakh, Maha] Qatar Univ, Biomed Res Ctr, Doha, Qatar.
   [Al-Asmakh, Maha] Qatar Univ, Qu Hlth, Coll Hlth Sci, Biomed Sci Dept, POB 2713, Doha, Qatar.
C3 Qatar University; Qatar University; Qatar University; Qatar University;
   Qatar University
RP Al-Asmakh, M (corresponding author), Qatar Univ, Qu Hlth, Coll Hlth Sci, Biomed Sci Dept, POB 2713, Doha, Qatar.
EM maha.alasmakh@qu.edu.qa
RI Zakaria, Zain/AAN-9420-2020
OI Sokary, Sara/0000-0001-5092-0153
FU Qatar University; Qatar National Library
FX Open Access funding provided by the Qatar National Library.
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NR 85
TC 4
Z9 4
U1 2
U2 11
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1939-0211
EI 1939-022X
J9 J DIET SUPPL
JI J. Diet. Suppl.
PD JUL 3
PY 2024
VL 21
IS 4
BP 527
EP 542
DI 10.1080/19390211.2023.2301366
EA JAN 2024
PG 16
WC Nutrition & Dietetics; Pharmacology & Pharmacy
WE Emerging Sources Citation Index (ESCI)
SC Nutrition & Dietetics; Pharmacology & Pharmacy
GA UU4S6
UT WOS:001147059800001
PM 38251049
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Huang, AH
   Roh, YS
   Sutaria, N
   Choi, J
   Williams, KA
   Canner, JK
   Grossberg, AL
   Kwatra, SG
AF Huang, Amy H.
   Roh, Youkyung Sophie
   Sutaria, Nishadh
   Choi, Justin
   Williams, Kyle A.
   Canner, Joseph K.
   Grossberg, Anna L.
   Kwatra, Shawn G.
TI Real-world comorbidities of atopic dermatitis in the pediatric
   ambulatory population in the United States
SO JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
LA English
DT Article
DE atopic dermatitis; comorbidities; eczema; MarketScan; pediatric
ID RESISTANT STAPHYLOCOCCUS-AUREUS; CHILDREN; ASSOCIATION; PREVALENCE;
   COLONIZATION; MANAGEMENT; PSORIASIS; DISEASES; ECZEMA; ADULTS
AB Background: Increasing evidence has suggested the systemic nature of atopic dermatitis (AD), a common inflammatory skin condition in children. However, comprehensive analyses of real-world comorbidities in pediatric AD are limited.
   Objective: To characterize comorbidity burden in patients with AD aged <18 years old.
   Methods: The MarketScan commercial claims database was queried from January 1, 2017, to December 31, 2017. Age-and sex-matched analyses were used to compare patients with AD with general population controls.
   Results: A total of 86,969 pediatric patients with AD and 116,564 matched controls were identified. Increased anxiety (odds ratio [OR], 1.20) and attention-deficit hyperactivity disorder (OR, 1.11) were noted in patients with AD. In addition to dermatologic/allergic diseases, AD was also associated with infections, including methicillin-resistant Staphylococcus aureus (OR, 3.76), and autoimmune conditions, including vitiligo (OR, 2.98) and alopecia areata (OR, 4.32). Pediatric patients with AD had higher likelihoods of lymphoid/hematologic malignancies (OR, 1.94), ocular disorders (OR, 1.37-2.02), metabolic syndrome (OR, 1.61), and obesity (OR, 1.81). For all the ORs mentioned above, P was <.001.
   Limitations: Retrospective analysis of health care claims data.
   Conclusions: AD in pediatric patients was associated with a wide range of psychologic and systemic comorbidities. Increased awareness can help minimize its negative effects on the quality of life and prevent long-term health consequences in young patients with AD.
C1 [Huang, Amy H.; Roh, Youkyung Sophie; Sutaria, Nishadh; Choi, Justin; Williams, Kyle A.; Grossberg, Anna L.; Kwatra, Shawn G.] Johns Hopkins Univ, Dept Dermatol, Sch Med, Baltimore, MD 21231 USA.
   [Huang, Amy H.; Kwatra, Shawn G.] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Baltimore, MD 21231 USA.
   [Canner, Joseph K.] Johns Hopkins Univ, Sch Med, Dept Surg, Johns Hopkins Surg Ctr Outcomes Res, Baltimore, MD 21231 USA.
C3 Johns Hopkins University; Johns Hopkins University; Johns Hopkins
   Bloomberg School of Public Health; Johns Hopkins University
RP Kwatra, SG (corresponding author), Johns Hopkins Univ, Sch Med, Canc Res Bldg 2,Suite 206,1550 Orleans St, Baltimore, MD 21231 USA.
EM skwatra1@jhmi.edu
FU Pfizer, Inc; Skin of Color Society; Dermatology Foundation Medical
   Dermatology Career Development Award
FX Dr Kwatra is supported by grant funding from Pfizer, Inc, the Skin of
   Color Society and a Dermatology Foundation Medical Dermatology Career
   Development Award.
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NR 59
TC 43
Z9 44
U1 0
U2 5
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0190-9622
EI 1097-6787
J9 J AM ACAD DERMATOL
JI J. Am. Acad. Dermatol.
PD OCT
PY 2021
VL 85
IS 4
BP 893
EP 900
DI 10.1016/j.jaad.2021.03.016
EA SEP 2021
PG 8
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA UQ7BD
UT WOS:000696215200015
PM 33689777
DA 2025-06-11
ER

PT J
AU Murdolo, G
   Piroddi, M
   Luchetti, F
   Tortoioli, C
   Canonico, B
   Zerbinati, C
   Galli, F
   Iuliano, L
AF Murdolo, Giuseppe
   Piroddi, Marta
   Luchetti, Francesca
   Tortoioli, Cristina
   Canonico, Barbara
   Zerbinati, Chiara
   Galli, Francesco
   Iuliano, Luigi
TI Oxidative stress and lipid peroxidation by-products at the crossroad
   between adipose organ dysregulation and obesity-linked insulin
   resistance
SO BIOCHIMIE
LA English
DT Review
DE Adipose tissue dysregulation; Insulin-resistance; Obesity; Oxidative
   stress preadipocytes
ID TYPE-2 DIABETES-MELLITUS; MESENCHYMAL STEM-CELLS; PPAR-GAMMA EXPRESSION;
   MARROW STROMAL CELLS; BODY-MASS INDEX; ADIPOCYTE DIFFERENTIATION;
   METABOLIC SYNDROME; GENE-EXPRESSION; REACTIVE OXYGEN; PREADIPOCYTE
   DIFFERENTIATION
AB Obesity has been proposed as an energy balance disorder in which the expansion of adipose tissue (AT) leads to unfavorable health outcomes. Even though adiposity represents the most powerful driving force for the development of insulin resistance (IR) and type 2 diabetes, mounting evidence points to "adipose dysregulation", rather than fat mass accrual per se, as a key pathophysiological trigger of the obesity-linked metabolic complications. The dysfunctional fat, besides hypertrophic adipose cells and inflammatory cues, displays a reduced ability to form new adipocytes from the undifferentiated precursor cells (ie, the preadipocytes). The failure of adipogenesis poses a "diabetogenic" milieu either by promoting the ectopic overflow/deposition of lipids in non-adipose targets (lipotoxicity) or by inducing a dysregulated secretion of different adipose-derived hormones (ie, adipokines and lipokines). This novel and provocative paradigm ("expandability hypothesis") further extends current "adipocentric view" implicating a reduced adipogenic capacity as a missing link between "unhealthy" fat expansion and impairment of metabolic homeostasis.
   Hitherto, reactive oxygen species have been implicated in multiple forms of IR. However, the effects of stress on adipogenesis remain controversial. Compelling circumstantial data indicate that lipid peroxidation by-products (ie, oxysterols and 4-hydrononenal) may detrimentally affect adipose homeostasis partly by impairing (pre)adipocyte differentiation. In this scenario, it is tempting to speculate that a fine tuning of the adipose redox status may provide new mechanistic insights at the interface between fat dysregulation and development of metabolic dysfunctions. Yet, in humans, the molecular "signatures" of oxidative stress in the dysregulated fat as well as the pathophysiological effects of adipose (per)oxidation on glucose homeostasis remain poorly investigated.
   In this review we will summarize the potential mechanisms by which increased oxidative stress in fat may impair (pre)adipocyte differentiation and promote the adipose dysfunction. We will also attempt to highlight the conundrum with the adipose redox changes and the regulation of glucose homeostasis. Finally, we will briefly discuss the scientific rationale for proposing the adipose redox state as a potential target for novel therapeutic strategies to curb/prevent adiposity-linked insulin resistance. (C) 2013 Elsevier Masson SAS. All rights reserved.
C1 [Murdolo, Giuseppe] Assisi Hosp, Dept Internal Med, I-06081 Perugia, Italy.
   [Piroddi, Marta; Galli, Francesco] Univ Perugia, Dept Internal Med, Sect Appl Biochem & Nutr Sci, I-06100 Perugia, Italy.
   [Luchetti, Francesca; Canonico, Barbara] Univ Carlo Bo, Dept Earth Life & Environm, Urbino, Italy.
   [Tortoioli, Cristina] Univ Perugia, Dept Internal Med, Sect Internal Med Endocrine & Metab Sci, I-06100 Perugia, Italy.
   [Zerbinati, Chiara; Iuliano, Luigi] Univ Roma La Sapienza, Dept Med Surg Sci & Biotechnol, Unit Vasc Med, Latina, Italy.
C3 University of Perugia; University of Perugia; University of Urbino;
   University of Perugia; Sapienza University Rome
RP Murdolo, G (corresponding author), Assisi Hosp, Dept Internal Med, Via Valentin Muller 1, I-06081 Perugia, Italy.
EM gmurdolo@tiscali.it
RI Murdolo, Giuseppe/I-1812-2012; Canonico, Barbara/AEP-0756-2022; Piroddi,
   Marta/K-5302-2016; Galli, Francesco/K-5048-2016; Iuliano,
   Luigi/A-5266-2008
OI Piroddi, Marta/0000-0002-0880-0630; Galli,
   Francesco/0000-0003-3626-051X; Iuliano, Luigi/0000-0002-0027-9326;
   Murdolo, Giuseppe/0000-0001-5654-1760; Canonico,
   Barbara/0000-0003-3383-715X
FU Fondazione Cassa di Risparmio di Perugia; Ricerca Scientifica e
   Tecnologica
FX This work was partly funded by grant from "Fondazione Cassa di Risparmio
   di Perugia; Ricerca Scientifica e Tecnologica".
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NR 134
TC 99
Z9 108
U1 0
U2 46
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0300-9084
EI 1638-6183
J9 BIOCHIMIE
JI Biochimie
PD MAR
PY 2013
VL 95
IS 3
BP 585
EP 594
DI 10.1016/j.biochi.2012.12.014
PG 10
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 111NM
UT WOS:000316528000018
PM 23274128
DA 2025-06-11
ER

PT J
AU Potenza, MA
   Gagliardi, S
   De Benedictis, L
   Zigrino, A
   Tiravanti, E
   Colantuono, G
   Federici, A
   Lorusso, L
   Benagiano, V
   Quon, MJ
   Montagnani, M
AF Potenza, Maria A.
   Gagliardi, Sara
   De Benedictis, Leonarda
   Zigrino, Addolorata
   Tiravanti, Edy
   Colantuono, Giuseppe
   Federici, Antonio
   Lorusso, Loredana
   Benagiano, Vincenzo
   Quon, Michael J.
   Montagnani, Monica
TI Treatment of spontaneously hypertensive rats with rosiglitazone
   ameliorates cardiovascular pathophysiology via antioxidant mechanisms in
   the vasculature
SO AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
LA English
DT Article
DE oxidative stress
ID ENHANCED SUPEROXIDE-PRODUCTION; ASSESSING INSULIN SENSITIVITY; ACTIVATED
   RECEPTOR-ALPHA; OXIDATIVE STRESS; ENDOTHELIAL DYSFUNCTION; NITRIC-OXIDE;
   PPAR-GAMMA; METABOLIC SYNDROME; IN-VIVO; INDUCED VASODILATION
AB Potenza MA, Gagliardi S, De Benedictis L, Zigrino A, Tiravanti E, Colantuono G, Federici A, Lorusso L, Benagiano V, Quon MJ, Montagnani M. Treatment of spontaneously hypertensive rats with rosiglitazone ameliorates cardiovascular pathophysiology via antioxidant mechanisms in the vasculature. Am J Physiol Endocrinol Metab 297: E685-E694, 2009. First published June 16, 2009; doi: 10.1152/ajpendo.00291.2009.-Oxidative stress contributes to cardiovascular complications of diabetes, in part, by reducing the bioavailability of nitric oxide (NO). We investigated the mechanisms whereby the insulin sensitizer rosiglitazone may ameliorate oxidative stress in the vasculature of spontaneously hypertensive rats (SHR). Nine-week-old SHR were treated by gavage for 7 wk with rosiglitazone (5 mg.kg(-1).day(-1)) or vehicle control. Treatment of SHR with rosiglitazone lowered systolic blood pressure, reduced fasting plasma insulin and asymmetrical dimethylarginine, and increased insulin sensitivity (when compared with vehicle treatment). In vessel homogenates and serum from rosiglitazone-treated SHR, SOD activity was enhanced, while 8-iso-PGF(2 alpha) (lipid peroxidation product) was reduced (when compared with samples from vehicle-treated SHR). Moreover, expression of p22phox (catalytic subunit of NADPH oxidase) as well as nitrotyrosine and superoxide content were all reduced in the aortas of rosiglitazone-treated SHR. In mesenteric vascular beds (MVB) isolated ex vivo from rosiglitazone-treated SHR, NO-dependent vasodilator actions of insulin were improved when compared with MVB from vehicle-treated SHR. Acute pretreatment of MVB from vehicle-treated SHR with apocynin (NADPH oxidase inhibitor) enhanced vasodilator actions of insulin (results comparable to those in MVB from rosiglitazone-treated SHR). In Langendorff heart preparations from rosiglitazone-treated SHR, ischemia/reperfusion injury caused infarcts 40% smaller than in hearts from vehicle-treated SHR. Acute pretreatment of hearts from vehicle-treated SHR with apocynin produced similar results. Finally, rosiglitazone treatment of endothelial cells in primary culture reduced superoxide induced by insulin-resistant conditions. We conclude that rosiglitazone therapy in SHR increases SOD activity and decreases p22phox expression in the vasculature to reduce oxidant stress leading to an improved cardiovascular phenotype.
C1 [Montagnani, Monica] Univ Bari, Dept Pharmacol & Human Physiol, Pharmacol Sect, Sch Med, I-70124 Bari, Italy.
   [Tiravanti, Edy; Colantuono, Giuseppe] Univ Bari, Dept Emergency & Transplants, I-70124 Bari, Italy.
   [Lorusso, Loredana; Benagiano, Vincenzo] Univ Bari, Dept Human Anat & Histol, I-70124 Bari, Italy.
   [Quon, Michael J.] Natl Ctr Complementary & Alternat Med, Diabet Unit, NIH, Bethesda, MD USA.
C3 Universita degli Studi di Bari Aldo Moro; Universita degli Studi di Bari
   Aldo Moro; Universita degli Studi di Bari Aldo Moro; National Institutes
   of Health (NIH) - USA; NIH National Center for Complementary &
   Alternative Medicine (NCCAM)
RP Montagnani, M (corresponding author), Univ Bari, Dept Pharmacol & Human Physiol, Pharmacol Sect, Sch Med, Policlin Piazza G Cesare 11, I-70124 Bari, Italy.
EM monica@farmacol.uniba.it
RI Quon, Michael/B-1970-2008; Montagnani, Monica/AAV-2057-2020
OI Potenza, Maria Assunta/0000-0002-9995-1468; Quon,
   Michael/0000-0002-9601-9915; BENAGIANO, VINCENZO/0000-0003-2579-9456;
   montagnani, monica/0000-0002-5697-8185; QUON,
   MICHAEL/0000-0002-5289-3707; federici, antonio/0000-0001-5102-9995
FU Italian Ministry for University and Research; Juvenile Diabetes Research
   Foundation [CDA 2-2006-32]; Intramural Research Program; National Center
   for Complementary and Alternative Medicine; National Institutes of
   Health
FX This work was supported, in part, by research grant awards from the
   Italian Ministry for University and Research and the Juvenile Diabetes
   Research Foundation (CDA 2-2006-32 to M. Montagnani) and by the
   Intramural Research Program, National Center for Complementary and
   Alternative Medicine, National Institutes of Health (to M. J. Quon).
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NR 77
TC 43
Z9 50
U1 0
U2 1
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0193-1849
EI 1522-1555
J9 AM J PHYSIOL-ENDOC M
JI Am. J. Physiol.-Endocrinol. Metab.
PD SEP
PY 2009
VL 297
IS 3
BP E685
EP E694
DI 10.1152/ajpendo.00291.2009
PG 10
WC Endocrinology & Metabolism; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Physiology
GA 484QW
UT WOS:000269063000014
PM 19531637
OA Green Published
DA 2025-06-11
ER

PT J
AU Makris, KC
   Heibati, B
   Narui, SZ
AF Makris, Konstantinos C.
   Heibati, Behzad
   Narui, Shan Zienolddiny
TI Chrono-modulated effects of external stressors on oxidative stress and
   damage in humans: A scoping review on night shift work
SO ENVIRONMENT INTERNATIONAL
LA English
DT Review
DE Oxidative stress; Personalized medicine; Personalized prevention;
   Precision medicine; Diurnal; Critical life stage; Circadian disruption;
   Chronobiology; Shift work
ID C-REACTIVE PROTEIN; CIRCADIAN MISALIGNMENT; OCCUPATIONAL STRESS;
   METABOLIC SYNDROME; SLEEP DURATION; RISK-FACTORS; DNA-DAMAGE;
   INFLAMMATION; BIOMARKERS; HEALTHY
AB Background: Oxidative stress and tissue damage (OSD) play a pivotal role as an early-stage process in chronic disease pathogenesis. However, there has been little research to better understand the temporal (xpovog[chronos]) dimensions of OSD process associated with environmental (non-genetic, including behaviors/lifestyle) and/or occupational stressors, like night shift work. OSD processes have recently attracted attention in relation to time-resolved external stressor trajectories in personalized medicine (prevention) initiatives, as they seem to interact with circadian clock systems towards the improved delineation of the early stages of (chronic) disease process.Objectives: This work critically reviewed human studies targeting the temporal dynamics of OSD and circadian clock system's activity in response to environmental/occupational stressors; the case of night shift work was examined.Methods: Being a key stressor influencing OSD processes and circadian rhythm, night shift work was evaluated as part of a scoping review of research in OSD, including inflammatory and metabolic processes to determine the extent of OSD research undertaken in human populations, methodologies, tools and biomarkers used and the extent that the temporal dimensions of exposure and biological effect(s) were accounted for. Online databases were searched for papers published from 2000 onwards, resulting in the selection of 53 original publications. Results and discussion: The majority of studies (n = 41) took place in occupational settings, while the rest were conducted in the general population or patient groups. Most occupational studies targeted outcomes of oxidative stress/damage (n = 19), followed by the combination of OSD with inflammatory response (n = 10), and studies focused on metabolic outcomes (n = 12). Only a minor fraction of the studies measured biomarkers related to circadian rhythm, such as, melatonin, its metabolite, or cortisol. Night shift work was associated with select biomarkers of OSD and inflammation, albeit with mixed results. Although much progress in delineating the biological mechanisms of OSD process has been made, an equally thorough investigation on the temporal trajectory of OSD processes as triggered by environmental/occupational stressors in human studies has yet to fully evolve.
C1 [Makris, Konstantinos C.; Heibati, Behzad] Cyprus Univ Technol, Cyprus Int Inst Environm & Publ Hlth, Limassol, Cyprus.
   [Heibati, Behzad] Canc Registry Norway, Dept Res, Oslo, Norway.
   [Narui, Shan Zienolddiny] Natl Inst Occupat Hlth, Oslo, Norway.
C3 Cyprus University of Technology; Cyprus International Institute for
   Environmental & Public Health; University of Oslo
RP Makris, KC (corresponding author), Cyprus Univ Technol, Cyprus Int Inst Environm & Publ Hlth, Limassol, Cyprus.
EM konstantinos.makris@cut.ac.cy
RI Makris, Konstantinos/GNP-4408-2022; Heibati, Behzad/AFK-6612-2022
OI Makris, Konstantinos/0000-0001-5251-8619; Heibati,
   Behzad/0000-0002-1640-8428
FU EXPOSOWORK project [OPPORTUNITY/0916/MSCA/0077]; European Regional
   Development Fund; Republic of Cyprus through the Research and Innovation
   Foundation
FX Heibati B. and K.C. Makris would like to acknowledge the partial funding
   support by the EXPOSOWORK project (OPPORTUNITY/0916/MSCA/0077) , co
   -financed by the European Regional Development Fund and the Republic of
   Cyprus through the Research and Innovation Foundation. The proposal has
   also received the Seal of Excellence by the European Commission as
   submitted in the Marie Sklodowska-Curie action H2020-MSCA-IF-2018. The
   authors would like to thank Ms. Maria Spyrou (CUT) and Oda Astrid Foss
   (NIOH) for their technical support in designing the high -quality
   schematics of this critical review. The funders had no role in study
   design, data collection and analysis, decision to publish, or
   preparation of the manuscript.
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NR 144
TC 8
Z9 9
U1 1
U2 4
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0160-4120
EI 1873-6750
J9 ENVIRON INT
JI Environ. Int.
PD AUG
PY 2023
VL 178
AR 108048
DI 10.1016/j.envint.2023.108048
EA JUL 2023
PG 23
WC Environmental Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology
GA O4KR0
UT WOS:001043524600001
PM 37463540
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Zeng, CR
   Chen, H
   Cao, T
   Wang, LW
   Jiao, SM
   Lin, CQ
   Zhang, BK
   Cai, HL
AF Zeng, Cuirong
   Chen, Hui
   Cao, Ting
   Wang, Liwei
   Jiao, Shimeng
   Lin, Chenquan
   Zhang, Bikui
   Cai, Hualin
TI B-GOS alleviates olanzapine-induced lipid disturbances in mice by
   enriching Akkermansia and upregulation of PGRMC1-Wnt signaling
SO FOOD AND CHEMICAL TOXICOLOGY
LA English
DT Article
DE Akkermansia; B-GOS; Lipotoxicity; Olanzapine; PGRMC1; Wnt pathway
ID GENE-EXPRESSION; ANTIPSYCHOTIC-DRUGS; METABOLIC SYNDROME; GUT
   MICROBIOME; SCHIZOPHRENIA; ANXIETY; OBESITY; BRAIN
AB Although olanzapine (OLZ) remains one of the most efficacious antipsychotic medications for the treatment of schizophrenia, there are significant tolerability issues related to its metabolic profile such as weight gain and dyslipidemia. Our previous studies have demonstrated that progesterone receptor membrane component 1 (PGRMC1) plays a key role in antipsychotic-induced metabolic side effects. Prebiotics showed positive effects on lipid metabolism, however, limited studies focused on their therapeutic potential and mechanisms in treating antipsychotic-induced lipid metabolic disorders. Herein, our study aims to explore the effects of the prebiotic BGOS on lipid disturbances induced by OLZ and elucidate its underlying mechanisms via PGRMC1 pathway. In an 8 -week study, long-term intraperitoneal administration of OLZ at a dosage of 8 mg/kg/day in mice induced lipid disturbances as manifested by significantly increased lipid indexes in plasma and liver. B-GOS effectively alleviated the OLZ-induced abnormal lipid metabolism by enhancing the diversity of the gut microbiota, with a 100fold increase in Akkermansia abundance and a 10 -fold decrease in Faecalibaculum abundance. Followed by the BGOS related changes of gut microbiota, OLZ-induced substantial hepatic inhibition of PGRMC1, and associated protein factors of Wnt signaling pathway (Wnt3a, beta-catenin, and PPAR-gamma) were reversed without affecting plasma levels of short -chain fatty acids. Taken together, prebiotics like B-GOS enriching Akkermansia offer a promising novel approach to alleviate antipsychotic-induced lipid disturbances by modulating the PGRMC1-Wnt signaling pathway.
C1 [Zeng, Cuirong; Chen, Hui; Cao, Ting; Wang, Liwei; Jiao, Shimeng; Lin, Chenquan; Zhang, Bikui; Cai, Hualin] Cent South Univ, Dept Pharm, Changsha, Peoples R China.
   [Zeng, Cuirong; Chen, Hui; Cao, Ting; Wang, Liwei; Jiao, Shimeng; Lin, Chenquan; Zhang, Bikui; Cai, Hualin] Cent South Univ, Inst Clin Pharm, Xiangya Hosp 2, Changsha, Peoples R China.
   [Zeng, Cuirong; Chen, Hui; Cao, Ting; Zhang, Bikui; Cai, Hualin] Cent South Univ, Xiangya Sch Pharmaceut Sci, Changsha, Peoples R China.
   [Zeng, Cuirong; Chen, Hui; Cao, Ting; Wang, Liwei; Jiao, Shimeng; Lin, Chenquan; Cai, Hualin] Cent South Univ, Natl Clin Res Ctr Mental Disorders, Xiangya Hosp 2, Changsha, Peoples R China.
   [Zeng, Cuirong; Chen, Hui; Cao, Ting; Wang, Liwei; Jiao, Shimeng; Lin, Chenquan; Zhang, Bikui; Cai, Hualin] Int Res Ctr Precis Med Transformat Technol & Softw, Changsha, Hunan, Peoples R China.
   [Cai, Hualin] Cent South Univ, Dept Pharm, 139 Middle Renmin Rd, Changsha 410011, Hunan, Peoples R China.
   [Cai, Hualin] Cent South Univ, Inst Clin Pharm, Xiangya Hosp 2, 139 Middle Renmin Rd, Changsha 410011, Hunan, Peoples R China.
C3 Central South University; Central South University; Central South
   University; Central South University; Central South University; Central
   South University
RP Cai, HL (corresponding author), Cent South Univ, Dept Pharm, 139 Middle Renmin Rd, Changsha 410011, Hunan, Peoples R China.; Cai, HL (corresponding author), Cent South Univ, Inst Clin Pharm, Xiangya Hosp 2, 139 Middle Renmin Rd, Changsha 410011, Hunan, Peoples R China.
EM hualincai@csu.edu.cn
FU Hunan Provincial Innovation Foundation For Postgraduate [CX20230289];
   Fundamental Research Funds for the Central Universities of Central South
   University [2023ZZTS0213, 2023ZZTS0883]; Hunan Pro-vincial Natural
   Science Foundation of China [2021JJ30922]; Hunan Provincial Health
   Commission Research Project [202113010595]; Talent Project established
   by Chinese Pharmaceutical Association Hospital Pharmacy Department
   [CPA-Z05-ZC-2021-003]; New Clinical Medical Technology Project of the
   Second Xiangya Hospital of Central South University [[2021] 94];
   Changsha Municipal Natural Science Foundation [kq2007045]
FX This work was supported in part by the grants from Hunan Provincial
   Innovation Foundation For Postgraduate [No. CX20230289] , the
   Fundamental Research Funds for the Central Universities of Central South
   University [No. 2023ZZTS0213, 2023ZZTS0883] , Hunan Provincial Natural
   Science Foundation of China [No. 2021JJ30922] , Hunan Provincial Health
   Commission Research Project [No. 202113010595] , Talent Project
   established by Chinese Pharmaceutical Association Hospital Pharmacy
   Department [No. CPA-Z05-ZC-2021-003] , New Clinical Medical Technology
   Project of the Second Xiangya Hospital of Central South University (
   [2021] 94) and Changsha Municipal Natural Science Foundation [kq2007045]
   .
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NR 47
TC 1
Z9 1
U1 2
U2 10
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0278-6915
EI 1873-6351
J9 FOOD CHEM TOXICOL
JI Food Chem. Toxicol.
PD MAR
PY 2024
VL 185
AR 114490
DI 10.1016/j.fct.2024.114490
EA FEB 2024
PG 12
WC Food Science & Technology; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Toxicology
GA KM3W5
UT WOS:001180355000001
PM 38325638
DA 2025-06-11
ER

PT J
AU Kwan, AC
   Wei, J
   Lee, BP
   Luong, E
   Salto, G
   Nguyen, TT
   Botting, PG
   Liu, YX
   Ouyang, D
   Ebinger, JE
   Li, DBA
   Noureddin, M
   Thomson, L
   Berman, DS
   Merz, CNB
   Cheng, SS
AF Kwan, Alan C.
   Wei, Janet
   Lee, Brian P.
   Luong, Eric
   Salto, Gerran
   Nguyen, Trevor-Trung
   Botting, Patrick G.
   Liu, Yunxian
   Ouyang, David
   Ebinger, Joseph E.
   Li, Debiao
   Noureddin, Mazen
   Thomson, Louise
   Berman, Daniel S.
   Merz, C. Noel Bairey
   Cheng, Susan
TI Subclinical hepatic fibrosis is associated with coronary microvascular
   dysfunction by myocardial perfusion reserve index: a retrospective
   cohort study
SO INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING
LA English
DT Article
DE Cardiac MRI; Hepatic fibrosis; Coronary perfusion
ID FATTY LIVER-DISEASE; HEART-FAILURE; FIB-4; RISK
AB The heart-liver axis is of growing importance. Previous studies have identified independent association of liver dysfunction and fibrosis with adverse cardiac outcomes, but mechanistic pathways remain uncertain. We sought to understand the relations between the degree of hepatic fibrosis identified by the Fibrosis-4 (Fib-4) risk score and comprehensive cardiac MRI (CMR) measures of subclinical cardiac disease. We conducted a retrospective single-center cohort study of patients between 2011 and 2021. We identified consecutive patients who underwent a comprehensive CMR imaging protocol including contrast enhanced with stress/rest perfusion, and lacked pre-existing cardiovascular disease or perfusion abnormalities on CMR. We examined the association of hepatic fibrosis, using the Fib-4 score, with subclinical cardiac disease on CMR while adjusting for cardiometabolic traits. Given known associations of hepatic disease and coronary microvascular dysfunction, we prioritized analyses with the myocardial perfusion reserve index (MPRI), a marker of coronary microvascular function. Of the 66 patients in our study cohort, 54 were female (81%) and the mean age was 53.7 +/- 15.3 years. We found that higher Fib-4 was associated with reduction in the MPRI (beta [SE] - 1.12 [0.46], P = 0.02), after adjusting for cardiometabolic risk factors. Importantly, Fib-4 was not significantly associated with any other CMR phenotypes including measures of cardiac remodeling, inflammation, fibrosis, or dysfunction. We found evidence that hepatic fibrosis associated with coronary microvascular dysfunction, in the absence of overt associations with any other subclinical cardiac disease measures. These findings highlight a potentially important precursor pathway leading to development of subsequent heart-liver disease.
C1 [Kwan, Alan C.; Wei, Janet; Luong, Eric; Salto, Gerran; Nguyen, Trevor-Trung; Botting, Patrick G.; Liu, Yunxian; Ouyang, David; Ebinger, Joseph E.; Li, Debiao; Noureddin, Mazen; Thomson, Louise; Berman, Daniel S.; Merz, C. Noel Bairey; Cheng, Susan] Cedars Sinai Med Ctr, Div Digest & Liver Dis, 127 S San Vicente Blvd A3600, Los Angeles, CA 90048 USA.
   [Kwan, Alan C.; Wei, Janet; Luong, Eric; Salto, Gerran; Nguyen, Trevor-Trung; Botting, Patrick G.; Liu, Yunxian; Ouyang, David; Ebinger, Joseph E.; Li, Debiao; Noureddin, Mazen; Thomson, Louise; Berman, Daniel S.; Merz, C. Noel Bairey; Cheng, Susan] Cedars Sinai Med Ctr, Dept Imaging, Barbra Streisand Womens Heart Ctr, Biomed Imaging Res Inst,Smidt Heart Inst Dept Car, 127 S San Vicente Blvd A3600, Los Angeles, CA 90048 USA.
   [Lee, Brian P.] Keck Sch Med USC, Dept Med, Los Angeles, CA USA.
C3 Cedars Sinai Medical Center; Cedars Sinai Medical Center
RP Kwan, AC (corresponding author), Cedars Sinai Med Ctr, Div Digest & Liver Dis, 127 S San Vicente Blvd A3600, Los Angeles, CA 90048 USA.; Kwan, AC (corresponding author), Cedars Sinai Med Ctr, Dept Imaging, Barbra Streisand Womens Heart Ctr, Biomed Imaging Res Inst,Smidt Heart Inst Dept Car, 127 S San Vicente Blvd A3600, Los Angeles, CA 90048 USA.
EM alan.kwan@cshs.org
RI berman, daniel/ABF-0670-2022; Li, Debiao/B-7622-2009; Cheng,
   Chi-An/AAD-7706-2022
OI Ouyang, David/0000-0002-3813-7518; Cheng, Susan/0000-0002-4977-036X;
   Kwan, Alan/0000-0002-4393-1011
FU Doris Duke Charitable Foundation [2020059]; Barbra Streisand Women's
   Cardiovascular Research and Education Program; Erika Glazer Women's
   Heart Health Project; Walter R. Ferguson Charitable Fund; Adelson Family
   Foundation
FX This work was supported in part by the Doris Duke Charitable Foundation
   Grant 2020059 (ACK), the Barbra Streisand Women's Cardiovascular
   Research and Education Program (CNB), the Linda Joy Pollin Women's Heart
   Health Program (NCB), the Erika Glazer Women's Heart Health Project
   (CNB), the Walter R. Ferguson Charitable Fund (CNB), and the Adelson
   Family Foundation (CNB).
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NR 33
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1569-5794
EI 1875-8312
J9 INT J CARDIOVAS IMAG
JI Int. J. Cardiovasc. Imaging
PD JUL
PY 2022
VL 38
IS 7
BP 1579
EP 1586
DI 10.1007/s10554-022-02546-7
EA FEB 2022
PG 8
WC Cardiac & Cardiovascular Systems; Radiology, Nuclear Medicine & Medical
   Imaging
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Radiology, Nuclear Medicine &
   Medical Imaging
GA 2X0VB
UT WOS:000749959300002
PM 35107770
OA Green Accepted
DA 2025-06-11
ER

PT J
AU García-Conesa, MT
   Chambers, K
   Combet, E
   Pinto, P
   Garcia-Aloy, M
   Andrés-Lacueva, C
   de Pascual-Teresa, S
   Mena, P
   Ristic, AK
   Hollands, WJ
   Kroon, PA
   Rodríguez-Mateos, A
   Istas, G
   Kontogiorgis, CA
   Rai, DK
   Gibney, ER
   Morand, C
   Espín, JC
   González-Sarrias, A
AF Garcia-Conesa, Maria-Teresa
   Chambers, Karen
   Combet, Emilie
   Pinto, Paula
   Garcia-Aloy, Mar
   Andres-Lacueva, Cristina
   de Pascual-Teresa, Sonia
   Mena, Pedro
   Ristic, Aleksandra Konic
   Hollands, Wendy J.
   Kroon, Paul A.
   Rodriguez-Mateos, Ana
   Istas, Geoffrey
   Kontogiorgis, Christos A.
   Rai, Dilip K.
   Gibney, Eileen R.
   Morand, Christine
   Carlos Espin, Juan
   Gonzalez-Sarrias, Antonio
TI Meta-Analysis of the Effects of Foods and Derived Products Containing
   Ellagitannins and Anthocyanins on Cardiometabolic Biomarkers: Analysis
   of Factors Influencing Variability of the Individual Responses
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE ellagitannins; anthocyanins; interindividual variability; meta-analysis;
   cardiometabolic disorders; pomegranate; nuts; berries; red wine; red
   grapes
ID LOW-DENSITY-LIPOPROTEIN; CRANBERRY JUICE CONSUMPTION; CARDIOVASCULAR
   RISK-FACTORS; RED WINE POLYPHENOLS; CONCORD GRAPE JUICE; POMEGRANATE
   EXTRACT SUPPLEMENTATION; IMPROVES ENDOTHELIAL FUNCTION; AMBULATORY
   BLOOD-PRESSURE; INDUCED OXIDATIVE STRESS; DOUBLE-BLIND
AB Understanding interindividual variability in response to dietary polyphenols remains essential to elucidate their effects on cardiometabolic disease development. A meta-analysis of 128 randomized clinical trials was conducted to investigate the effects of berries and red grapes/wine as sources of anthocyanins and of nuts and pomegranate as sources of ellagitannins on a range of cardiometabolic risk biomarkers. The potential influence of various demographic and lifestyle factors on the variability in the response to these products were explored. Both anthocyanin-and ellagitannin-containing products reduced total-cholesterol with nuts and berries yielding more significant effects than pomegranate and grapes. Blood pressure was significantly reduced by the two main sources of anthocyanins, berries and red grapes/wine, whereas waist circumference, LDL-cholesterol, triglycerides, and glucose weremost significantly lowered by the ellagitannin-products, particularly nuts. Additionally, we found an indication of a small increase in HDL-cholesterol most significant with nuts and, in flow-mediated dilation by nuts and berries. Most of these effects were detected in obese/overweight people but we found limited or non-evidence in normoweight individuals or of the influence of sex or smoking status. The effects of other factors, i.e., habitual diet, health status or country where the study was conducted, were inconsistent and require further investigation.
C1 [Garcia-Conesa, Maria-Teresa; Carlos Espin, Juan; Gonzalez-Sarrias, Antonio] CSIC, CEBAS, Res Grp Qual Safety & Bioact Plant Foods, POB 164,Campus Espinardo, Murcia 30100, Spain.
   [Chambers, Karen; Hollands, Wendy J.; Kroon, Paul A.] Quadram Inst Biosci, Norwich Res Pk, Norwich, Norfolk, England.
   [Combet, Emilie] Univ Glasgow, Coll Med Vet & Life Sci, Sch Med Dent & Nursing, Human Nutr, Glasgow G31 2ER, Lanark, Scotland.
   [Pinto, Paula] Polytech Inst Santarem, ESA, Dept Food Technol, Biotechnol & Nutr, P-2001904 Santarem, Portugal.
   [Pinto, Paula] Inst Tecnol Quim & Biol, iBET, Mol Nutr Hlth Lab, P-2780157 Oeiras, Portugal.
   [Garcia-Aloy, Mar; Andres-Lacueva, Cristina] Univ Barcelona, Fac Pharm & Food Sci, Dept Nutr Food Sci & Gastron, Biomarkers & Nutrimetab Lab,XaRTA,INSA, E-08028 Barcelona, Spain.
   [Garcia-Aloy, Mar; Andres-Lacueva, Cristina] Inst Salud Carlos III, CIBER Fragilidad & Envejecimiento Saludable CIBER, Barcelona 08028, Spain.
   [de Pascual-Teresa, Sonia] CSIC, Inst Food Sci Technol & Nutr ICTAN, Inst Food Sci, Dept Metab & Nutr, E-28040 Madrid, Spain.
   [Mena, Pedro] Univ Parma, Dept Food Drug, Human Nutr Unit, I-43125 Parma, Italy.
   [Ristic, Aleksandra Konic] Univ Belgrade, Inst Med Res, Belgrade 11000, Serbia.
   [Ristic, Aleksandra Konic] Univ Leeds, Sch Food Sci & Nutr, Leeds LS2 9JT, W Yorkshire, England.
   [Rodriguez-Mateos, Ana; Istas, Geoffrey] Kings Coll London, Fac Life Sci & Med, Sch Life Course Sci, Dept Nutr Sci, London SE1 9NH, England.
   [Kontogiorgis, Christos A.] Democritus Univ Thrace, Dept Med, Lab Hyg & Environm Protect, Alexandroupolis 68100, Greece.
   [Rai, Dilip K.] Teagasc Food Res Ctr Ashtown, Dublin D15 KN3K, Ireland.
   [Gibney, Eileen R.] UCD, Inst Food & Hlth, Dublin 4, Ireland.
   [Morand, Christine] UCA, CRNH Auvergne, INRA, Human Nutr Unit, F-63000 Clermont Ferrand, France.
C3 Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Centro de
   Edafologia y Biologia Aplicada del Segura (CEBAS); UK Research &
   Innovation (UKRI); Biotechnology and Biological Sciences Research
   Council (BBSRC); Quadram Institute; University of Glasgow; Instituto
   Politecnico de Santarem; University of Barcelona; Instituto de Salud
   Carlos III; CIBER - Centro de Investigacion Biomedica en Red; CIBERFES;
   Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Instituto
   de Ciencia y Tecnologia de Alimentos y Nutricion (ICTAN); University of
   Parma; University of Belgrade; University of Leeds; University of
   London; King's College London; Democritus University of Thrace; Teagasc;
   INRAE
RP García-Conesa, MT; González-Sarrias, A (corresponding author), CSIC, CEBAS, Res Grp Qual Safety & Bioact Plant Foods, POB 164,Campus Espinardo, Murcia 30100, Spain.
EM mtconesa@cebas.csic.es; Karen.Chambers@quadram.ac.uk;
   emilie.combetAspray@glasgow.ac.uk; paula.pinto@esa.ipsantarem.pt;
   margarcia@ub.edu; candres@ub.edu; s.depascualteresa@csic.es;
   pedromiguel.menaparreno@unipr.it; a.konicristic@leeds.ac.uk;
   wendy.hollands@quadram.ac.uk; paul.kroon@quadram.ac.uk;
   ana.rodriguez-mateos@kcl.ac.uk; g.istas@kcl.ac.uk; ckontogi@med.duth.gr;
   dilip.rai@teagasc.ie; eileen.gibney@ucd.ie; christine.morand@inra.fr;
   jcespin@cebas.csic.es; agsarrias@cebas.csic.es
RI Konic Ristic, Aleksandra/KDM-9154-2024; Rodriguez-Mateos,
   Ana/ABE-1560-2020; Pinto, Paula/GSD-4552-2022; Gonzalez-Sarrias,
   Antonio/P-5846-2014; Garcia-Aloy, Mar/A-9141-2012; MORAND,
   Christine/P-6988-2018; Espin, Juan Carlos/G-6231-2011; Rai,
   Dilip/E-9022-2011; Garcia Conesa, Maria Teresa/N-4032-2014;
   Andres-Lacueva, Cristina/J-3377-2012; Mena, Pedro/P-6353-2019; de
   Pascual-Teresa, Sonia/F-5321-2011; Kroon, Paul/H-5384-2013
OI Gonzalez-Sarrias, Antonio/0000-0002-3407-0678; Garcia-Aloy,
   Mar/0000-0002-1330-6610; MORAND, Christine/0000-0001-8128-1032; Espin,
   Juan Carlos/0000-0002-1068-8692; Rai, Dilip/0000-0002-8073-4981; Pinto,
   Paula/0000-0001-6379-1768; Garcia Conesa, Maria
   Teresa/0000-0002-4125-853X; Andres-Lacueva,
   Cristina/0000-0002-8494-4978; Rodriguez-Mateos, Ana/0000-0003-3242-402X;
   Mena, Pedro/0000-0003-2150-2977; Cordoba Mena,
   Franklin/0000-0001-5292-6225; Combet, Emilie/0000-0002-9302-8971; de
   Pascual-Teresa, Sonia/0000-0001-8546-8507; Kroon,
   Paul/0000-0002-9805-6947
FU COST (European Cooperation in Science and Technology) [FA1403-POSITIVe];
   COST Action "POSITIVe" [FA1403]; BBSRC [BBS/E/F/00044434, BB/N023951/1]
   Funding Source: UKRI
FX This article is based upon work from COST Action FA1403-POSITIVe
   "Interindividual variation in response to consumption of plant food
   bioactives and determinants involved" supported by COST (European
   Cooperation in Science and Technology, http://www.cost.eu/). The authors
   thank the financial support of the COST Action FA1403 "POSITIVe" to
   conduct a short-term scientific mission to K.C. at CEBAS-CSIC (A.G.-S.
   and M.T.G.-C.) during which the data analysis was performed.
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NR 201
TC 112
Z9 116
U1 0
U2 38
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD MAR
PY 2018
VL 19
IS 3
AR 694
DI 10.3390/ijms19030694
PG 33
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA GA4OO
UT WOS:000428309800051
PM 29495642
OA Green Submitted, Green Published, Green Accepted, gold
DA 2025-06-11
ER

PT J
AU Kaya, H
   Ertas, F
   Oylumlu, M
   Bilik, MZ
   Yildiz, A
   Yüksel, M
   Polat, N
   Acet, H
   Isik, F
   Ülgen, MS
AF Kaya, Hasan
   Ertas, Faruk
   Oylumlu, Mustafa
   Bilik, Mehmet Zihni
   Yildiz, Abdulkadir
   Yuksel, Murat
   Polat, Nihat
   Acet, Halit
   Isik, Ferhat
   Ulgen, Mehmet Siddik
TI Relation of epicardial fat thickness and brachial flow-mediated
   vasodilation with coronary artery disease
SO JOURNAL OF CARDIOLOGY
LA English
DT Article
DE Coronary artery disease; Epicardial fat thickness; Flow-mediated
   vasodilation
ID ADIPOSE-TISSUE; OXIDATIVE STRESS; ENDOTHELIAL DYSFUNCTION;
   CARDIOVASCULAR-DISEASE; INFLAMMATION; ECHOCARDIOGRAPHY; ATHEROSCLEROSIS;
   RISK; ASSOCIATION; ULTRASOUND
AB Objective: The purpose of this study is to investigate the presence of a statistical association between epicardial fat thickness (EFT) and coronary artery disease (CAD) and between flow-mediated vasodilation (FMD) and CAD.
   Methods: We measured the EFT and FMD in 64 subjects with suspected stable angina pectoris. The patients were separated into two groups according to their coronary angiography results: 34 patients with CAD and 30 patients with normal coronary arteries (NCA).
   Results: EFT was significantly higher in the patients with CAD than the NCA group (6.43 +/- 0.90 mm vs. 5.35 +/- 0.75 mm, p < 0.001) while FMD was significantly lower in the patients with CAD than those in the NCA group (6.41 +/- 2.51% vs. 8.33 +/- 3.45%, p = 0.015). No significant correlation was found between EFT and FMD. After adjustment for EFT, FMD, age, sex, ejection fraction, glucose, and low-density lipoprotein cholesterol through multivariate logistic regression analysis, EFT (odds ratio: 6.325,95% confidence interval 2.289-17.476, p < 0.001) and age (odds ratio: 1.093, 95% confidence interval 1.008-1.185, p = 0.032) remained significant predictors of CAD. A cut-off value of EFT >= 5.8 mm predicted the presence of CAD with 77% sensitivity and 70% specificity.
   Conclusion: An echocardiographic EFT assessment is independently associated with the presence of CAD. Thus, EFT may be helpful in cardiometabolic risk stratification and therapeutic interventions. (C) 2013 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved.
C1 [Kaya, Hasan; Ertas, Faruk; Oylumlu, Mustafa; Bilik, Mehmet Zihni; Yildiz, Abdulkadir; Yuksel, Murat; Polat, Nihat; Acet, Halit; Isik, Ferhat; Ulgen, Mehmet Siddik] Dicle Univ, Fac Med, Dept Cardiol, Diyarbakir, Turkey.
C3 Dicle University
RP Kaya, H (corresponding author), Dicle Univ, Fac Med, Dept Cardiol, Diyarbakir, Turkey.
EM dr_hasankaya@yahoo.com
RI Isik, Ferhat/AEW-6914-2022; Ertas, Faruk/N-6409-2013; YILDIZ,
   Abdulkadir/A-2857-2015; Yuksel, Murat/B-7287-2013; KAYA,
   HASAN/F-8496-2013
OI Yuksel, Murat/0000-0003-2636-5211; Isik, Ferhat/0000-0002-1438-3327;
   KAYA, HASAN/0000-0003-3923-4026; Yildiz, Abdulkadir/0000-0002-2291-5071
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NR 42
TC 10
Z9 11
U1 1
U2 22
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0914-5087
EI 1876-4738
J9 J CARDIOL
JI J. Cardiol.
PD NOV-DEC
PY 2013
VL 62
IS 5-6
BP 343
EP 347
DI 10.1016/j.jjcc.2013.05.009
PG 5
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 273ID
UT WOS:000328527600014
PM 23810068
DA 2025-06-11
ER

PT J
AU Driessen, S
   Francque, SM
   Anker, SD
   Cabezas, MC
   Grobbee, DE
   Tushuizen, ME
   Holleboom, AG
AF Driessen, Stan
   Francque, Sven M.
   Anker, Stefan D.
   Cabezas, Manuel Castro
   Grobbee, Diederick E.
   Tushuizen, Maarten E.
   Holleboom, Adriaan G.
TI Metabolic dysfunction-associated steatotic liver disease and the heart
SO HEPATOLOGY
LA English
DT Review; Early Access
ID OBSTRUCTIVE SLEEP-APNEA; GLYCATION END-PRODUCTS; INCREASED
   ENERGY-EXPENDITURE; RENIN-ANGIOTENSIN SYSTEM; FATTY LIVER;
   INSULIN-RESISTANCE; CARDIOVASCULAR-DISEASE; NONALCOHOLIC
   STEATOHEPATITIS; OXIDATIVE STRESS; ATRIAL-FIBRILLATION
AB The prevalence and severity of metabolic dysfunction-associated steatotic liver disease (MASLD) are increasing. Physicians who treat patients with MASLD may acknowledge the strong coincidence with cardiometabolic disease, including atherosclerotic cardiovascular disease (asCVD). This raises questions on co-occurrence, causality, and the need for screening and multidisciplinary care for MASLD in patients with asCVD, and vice versa. Here, we review the interrelations of MASLD and heart disease and formulate answers to these matters. Epidemiological studies scoring proxies for atherosclerosis and actual cardiovascular events indicate increased atherosclerosis in patients with MASLD, yet no increased risk of asCVD mortality. MASLD and asCVD share common drivers: obesity, insulin resistance and type 2 diabetes mellitus (T2DM), smoking, hypertension, and sleep apnea syndrome. In addition, Mendelian randomization studies support that MASLD may cause atherosclerosis through mixed hyperlipidemia, while such evidence is lacking for liver-derived procoagulant factors. In the more advanced fibrotic stages, MASLD may contribute to heart failure with preserved ejection fraction by reduced filling of the right ventricle, which may induce fatigue upon exertion, often mentioned by patients with MASLD. Some evidence points to an association between MASLD and cardiac arrhythmias. Regarding treatment and given the strong co-occurrence of MASLD and asCVD, pharmacotherapy in development for advanced stages of MASLD would ideally also reduce cardiovascular events, as has been demonstrated for T2DM treatments. Given the common drivers, potential causal factors and especially given the increased rate of cardiovascular events, comprehensive cardiometabolic risk management is warranted in patients with MASLD, preferably in a multidisciplinary approach.
C1 [Driessen, Stan; Holleboom, Adriaan G.] Univ Amsterdam, Dept Vasc Med, Med Ctr, Amsterdam, Netherlands.
   [Francque, Sven M.] Univ Hosp Antwerp, Dept Gastroenterol & Hepatol, Antwerp, Belgium.
   [Anker, Stefan D.] Charite, Inst Hlth Ctr Regenerat Therapies BCRT, Dept Cardiol CVK German Heart Ctr Charite, Dept Cardiol CVK,German Heart Ctr Charite, Berlin, Germany.
   [Anker, Stefan D.] Wroclaw Med Univ, Inst Heart Dis, Wroclaw, Poland.
   [Cabezas, Manuel Castro; Grobbee, Diederick E.] Julius Clin, Zeist, Netherlands.
   [Cabezas, Manuel Castro] Franciscus Gasthuis & Vlietland, Dept Internal Med, Rotterdam, Netherlands.
   [Cabezas, Manuel Castro] Dept Internal Med & Endocrinol, Erasmus MC, Rotterdam, Netherlands.
   [Grobbee, Diederick E.] Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands.
   [Tushuizen, Maarten E.] Leiden Univ, Dept Gastroenterol & Hepatol, Med Ctr, Leiden, Netherlands.
   [Holleboom, Adriaan G.] Univ Amsterdam, Dept Vasc Med, Med Ctr, Meibergdreef 9,Room D3-314, NL-1105AZ Amsterdam, Netherlands.
C3 University of Amsterdam; University of Antwerp; Berlin Institute of
   Health; Free University of Berlin; Humboldt University of Berlin;
   Charite Universitatsmedizin Berlin; Wroclaw Medical University;
   Franciscus Gasthuis; Erasmus University Rotterdam; Erasmus MC; Utrecht
   University; Utrecht University Medical Center; Leiden University; Leiden
   University Medical Center (LUMC); Leiden University - Excl LUMC;
   University of Amsterdam
RP Holleboom, AG (corresponding author), Univ Amsterdam, Dept Vasc Med, Med Ctr, Meibergdreef 9,Room D3-314, NL-1105AZ Amsterdam, Netherlands.
EM s.driessen2@amsterdamumc.nl; sven.francque@uza.be; s.anker@cachexia.de;
   manuel.cabezas@juliusclinical.com; d.E.Grobbee@umcutrecht.nl;
   m.e.tushuizen@lumc.nl; a.g.holleboom@amsterdamumc.nl
RI Grobbee, Diederick/C-7651-2014; Francque, sven/E-4526-2017
OI Grobbee, Diederick/0000-0003-4472-4468; Anker,
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NR 160
TC 31
Z9 32
U1 6
U2 14
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0270-9139
EI 1527-3350
J9 HEPATOLOGY
JI Hepatology
PD 2023 DEC 25
PY 2023
DI 10.1097/HEP.0000000000000735
EA DEC 2023
PG 17
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA JB2D7
UT WOS:001170619400001
PM 38147315
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Zheng, J
   Lee, J
   Byun, J
   Yu, D
   Ha, JH
AF Zheng, Jiaxiang
   Lee, Jisu
   Byun, Jaemin
   Yu, Daeung
   Ha, Jung-Heun
TI Partial replacement of high-fat diet with n-3 PUFAs enhanced beef
   tallow attenuates dyslipidemia and endoplasmic reticulum stress in
   tunicamycin-injected rats
SO FRONTIERS IN NUTRITION
LA English
DT Article
DE high fat high cholesterol diet; beef tallow; n-3 PUFAs; dyslipidemia;
   unfolded protein responses
ID METABOLIC SYNDROME; MEDITERRANEAN DIET; INSULIN-RESISTANCE;
   CARDIOVASCULAR-DISEASE; GLUCOSE-TOLERANCE; ALPHA-TOCOPHEROL;
   LIVER-DISEASE; HEALTH VALUE; ER STRESS; ACIDS
AB IntroductionMetabolic syndrome (MetS) is considered as a complex, intertwined multiple risk factors that directly increase the risk of various metabolic diseases, especially cardiovascular atherosclerotic diseases and diabetes mellitus type 2. While lifestyle changes, including dietary intervention are effective in mitigating or preventing MetS, there are no specific therapies against MetS. Typical western diets comprise of high saturated fatty acid, cholesterol, and simple sugar; consequently their consumption may increase the potential pathological developmental risk of MetS. Partial replacement of dietary fatty acids with polyunsaturated fatty acids (PUFAs) is widely recommended measure to manage MetS-related disorders. MethodsIn the present study, we used rat model to investigate the role of n-3 PUFA enriched beef tallows (BT) on MetS and tunicamycin (TM)-induced endoplasmic reticulum (ER) stress, by partially replacing dietary fat (lard) with equal amounts of two different BTs; regular BT or n-3 PUFA-enriched BT. The experimental rats were randomly assigned to three different dietary groups (n = 16 per group): (1) high-fat and high-cholesterol diet (HFCD); (2) HFCD partially replaced with regular BT (HFCD + BT1); (3) HFCD partially replaced with n-3 enhanced BT (w/w) (HFCD + BT2). After 10 weeks of dietary intervention, each experimental rodent was intraperitoneally injected with either phosphate-buffered saline or 1 mg/kg body weight of TM. ResultsHFCD + BT2 showed improved dyslipidemia before TM injection, and increased serum high-density lipoprotein cholesterol (HDL-C) levels after TM injection. BT replacement groups had significantly reduced hepatic triglyceride (TG) levels, and decreased total cholesterol (TC) and TG levels in epididymal adipose tissue (EAT). Furthermore, BT replacement remarkably attenuated TM-induced unfolded protein responses (UPRs) in liver, showing reduced ER stress, with BT2 being more effective in the EAT. DiscussionTherefore, our findings suggest that partially replacing dietary fats with n-3 PUFA to lower the ratio of n-6/n-3 PUFAs is beneficial in preventing pathological features of MetS by alleviating HFCD- and/or TM-induced dyslipidemia and ER stress.
C1 [Zheng, Jiaxiang; Lee, Jisu; Ha, Jung-Heun] Dankook Univ, Dept Food Sci & Nutr, Cheonan, South Korea.
   [Byun, Jaemin] Hackensack Meridian Hlth, Ctr Discovery & Innovat, Nutley, NJ USA.
   [Yu, Daeung] Changwon Natl Univ, Dept Food & Nutr, Chang Won, South Korea.
   [Yu, Daeung] Changwon Natl Univ, Interdisciplinary Program Sr Human Ecol, Major Food & Nutr, Chang Won, South Korea.
   [Ha, Jung-Heun] Dankook Univ, Res Ctr Ind Nat Neutralizat, Yongin, South Korea.
C3 Dankook University; Changwon National University; Changwon National
   University; Dankook University
RP Ha, JH (corresponding author), Dankook Univ, Dept Food Sci & Nutr, Cheonan, South Korea.; Yu, D (corresponding author), Changwon Natl Univ, Dept Food & Nutr, Chang Won, South Korea.; Yu, D (corresponding author), Changwon Natl Univ, Interdisciplinary Program Sr Human Ecol, Major Food & Nutr, Chang Won, South Korea.; Ha, JH (corresponding author), Dankook Univ, Res Ctr Ind Nat Neutralizat, Yongin, South Korea.
EM duyu@cwnu.ac.kr; ha@dankook.ac.kr
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U2 5
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD MAR 16
PY 2023
VL 10
AR 1155436
DI 10.3389/fnut.2023.1155436
PG 15
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA C0OQ6
UT WOS:000959021000001
PM 37006935
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU González-Rámila, S
   Mateos, R
   García-Cordero, J
   Seguido, MA
   Bravo-Clemente, L
   Sarriá, B
AF Gonzalez-Ramila, Susana
   Mateos, Raquel
   Garcia-Cordero, Joaquin
   Seguido, Miguel A.
   Bravo-Clemente, Laura
   Sarria, Beatriz
TI Olive Pomace Oil versus High Oleic Sunflower Oil and Sunflower Oil: A
   Comparative Study in Healthy and Cardiovascular Risk Humans
SO FOODS
LA English
DT Article
DE olive pomace oil; high oleic sunflower oil; sunflower oil; lipid
   profile; lipid peroxidation; anthropometric parameters; clinical trial
ID PERFORMANCE LIQUID-CHROMATOGRAPHY; CONJUGATED LINOLEIC-ACID; OXIDATIVE
   STRESS; OLEANOLIC ACID; GLUCOSE-TOLERANCE; FAT; CHOLESTEROL;
   CONSUMPTION; MECHANISMS; IMPROVES
AB Olive pomace oil (OPO) is mainly a source of monounsaturated fat together with a wide variety of bioactive compounds, such as triterpenic acids and dialcohols, squalene, tocopherols, sterols and aliphatic fatty alcohols. To date, two long-term intervention studies have evaluated OPO's health effects in comparison with high oleic sunflower oil (HOSO, study-1) and sunflower oil (SO, study-2) in healthy and cardiovascular risk subjects. The present study integrates the health effects observed with the three oils. Two randomized, blinded, cross-over controlled clinical trials were carried out in 65 normocholesterolemic and 67 moderately hypercholesterolemic subjects. Each study lasted fourteen weeks, with two four-week intervention phases (OPO versus HOSO or SO), each preceded by a three-week run-in or washout period. Regular OPO consumption reduced total cholesterol (p = 0.017) and LDL cholesterol (p = 0.018) levels as well as waist circumference (p = 0.026), and only within the healthy group did malondialdehyde (p = 0.004) levels decrease after OPO intake versus HOSO. Contrarily, after the SO intervention, apolipoprotein (Apo) B (p < 0.001) and Apo B/Apo A ratio (p < 0.001) increased, and to a lower extent Apo B increased with OPO. There were no differences between the study groups. OPO intake may improve cardiometabolic risk, particularly through reducing cholesterol-related parameters and waist circumference in healthy and hypercholesterolemic subjects.
C1 [Gonzalez-Ramila, Susana; Mateos, Raquel; Garcia-Cordero, Joaquin; Seguido, Miguel A.; Bravo-Clemente, Laura; Sarria, Beatriz] CSIC, Inst Food Sci Technol & Nutr ICTAN CSIC, Dept Metab & Nutr, Jose Antonio Novais 10, Madrid 28040, Spain.
C3 Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Instituto
   de Ciencia y Tecnologia de Alimentos y Nutricion (ICTAN)
RP Sarriá, B (corresponding author), CSIC, Inst Food Sci Technol & Nutr ICTAN CSIC, Dept Metab & Nutr, Jose Antonio Novais 10, Madrid 28040, Spain.
EM s.gonzalez@ictan.csic.es; raquel.mateos@ictan.csic.es;
   j.garcia@ictan.csic.es; m.seguido@ictan.csic.es; lbravo@ictan.csic.es;
   beasarria@ictan.csic.es
RI Bravo, Laura/JMC-4928-2023; BRIZ, Raquel/H-9125-2012; Bravo,
   Laura/F-4992-2012; Sarria, Beatriz/K-7929-2014
OI Bravo, Laura/0000-0002-7312-8641; Seguido, Miguel
   Angel/0000-0003-3883-7503; Sarria, Beatriz/0000-0003-0614-4606
FU Interprofesional del Aceite de Orujo de Oliva (ORIVA); Community of
   Madrid [PEJD-2017-PRE/BIO-4225, PEJD-2018-PRE/SAL-9104]
FX Interprofesional del Aceite de Orujo de Oliva (ORIVA) financed the study
   and the predoctoral contract of SG-R. Community of Madrid partly
   financed the predoctoral contracts of JG-C (PEJD-2017-PRE/BIO-4225) and
   MAS (PEJD-2018-PRE/SAL-9104). No other conflicts of interests are
   declared. ORIVA had no part on the design, conductance, analysis or
   interpretation of results.
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NR 64
TC 23
Z9 23
U1 0
U2 20
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2304-8158
J9 FOODS
JI Foods
PD AUG
PY 2022
VL 11
IS 15
AR 2186
DI 10.3390/foods11152186
PG 20
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA 3S8NX
UT WOS:000839847400001
PM 35892771
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Danielak, A
   Wojcik, D
   Mazur-Bialy, A
   Surmiak, M
   Bilski, J
   Targosz, A
   Magierowski, M
   Chmura, A
   Strzalka, M
   Krzysiek-Maczka, G
   Magierowska, K
   Szczyrk, U
   Kwiecien, S
   Ptak-Belowska, A
   Brzozowski, T
AF Danielak, Aleksandra
   Wojcik, Dagmara
   Mazur-Bialy, Agnieszka
   Surmiak, Marcin
   Bilski, Jan
   Targosz, Aneta
   Magierowski, Marcin
   Chmura, Anna
   Strzalka, Malgorzata
   Krzysiek-Maczka, Gracjana
   Magierowska, Katarzyna
   Szczyrk, Urszula
   Kwiecien, Slawomir
   Ptak-Belowska, Agata
   Brzozowski, Tomasz
TI Intestinal Alkaline Phosphatase Combined with Voluntary Physical
   Activity Alleviates Experimental Colitis in Obese Mice. Involvement of
   Oxidative Stress, Myokines, Adipokines and Proinflammatory Biomarkers
SO ANTIOXIDANTS
LA English
DT Article
DE experimental colitis; intestinal alkaline phosphatase; exercise;
   inflammatory bowel disease; physical activity; oxidative stress;
   myokines; adipokines; antioxidative factors
ID INFLAMMATORY-BOWEL-DISEASE; DIET-INDUCED OBESITY; QUALITY-OF-LIFE;
   ADIPOSE-TISSUE; SKELETAL-MUSCLE; CROHNS-DISEASE; GASTROINTESTINAL
   COMPLAINTS; METABOLIC SYNDROME; COLONIC-MUCOSA; POTENTIAL ROLE
AB Intestinal alkaline phosphatase (IAP) is an essential mucosal defense factor involved in the process of maintenance of gut homeostasis. We determined the effect of moderate exercise (voluntary wheel running) with or without treatment with IAP on the course of experimental murine 2,4,6-trinitrobenzenesulfonic acid (TNBS) colitis by assessing disease activity index (DAI), colonic blood flow (CBF), plasma myokine irisin levels and the colonic and adipose tissue expression of proinflammatory cytokines, markers of oxidative stress (SOD2, GPx) and adipokines in mice fed a standard diet (SD) or high-fat diet (HFD). Macroscopic and microscopic colitis in sedentary SD mice was accompanied by a significant decrease in CBF, and a significant increase in the colonic expression of tumor necrosis factor-alpha (TNF-alpha), IL-6, IL-1 beta and leptin mRNAs and decrease in the mRNA expression of adiponectin. These effects were aggravated in sedentary HFD mice but reduced in exercising animals, potentiated by concomitant treatment with IAP, especially in obese mice. Exercising HFD mice demonstrated a substantial increase in the mRNA for adiponectin and a decrease in mRNA leptin expression in intestinal mucosa and mesenteric fat as compared to sedentary animals. The expression of SOD2 and GPx mRNAs was significantly decreased in adipose tissue in HFD mice, but these effects were reversed in exercising mice with IAP administration. Our study shows for the first time that the combination of voluntary exercise and oral IAP treatment synergistically favored healing of intestinal inflammation, strengthened the antioxidant defense and ameliorated the course of experimental colitis; thus, IAP may represent a novel adjuvant therapy to alleviate inflammatory bowel disease (IBD) in humans.
C1 [Danielak, Aleksandra; Wojcik, Dagmara; Surmiak, Marcin; Targosz, Aneta; Magierowski, Marcin; Chmura, Anna; Strzalka, Malgorzata; Krzysiek-Maczka, Gracjana; Magierowska, Katarzyna; Szczyrk, Urszula; Kwiecien, Slawomir; Ptak-Belowska, Agata; Brzozowski, Tomasz] Jagiellonian Univ Med Coll, Dept Physiol, Fac Med, 16 Grzegorzecka St, PL-31531 Krakow, Poland.
   [Mazur-Bialy, Agnieszka; Bilski, Jan] Jagiellonian Univ Med Coll, Dept Biomech & Kinesiol, Fac Hlth Sci, 20 Grzegorzecka St, PL-31531 Krakow, Poland.
C3 Jagiellonian University; Collegium Medicum Jagiellonian University;
   Jagiellonian University; Collegium Medicum Jagiellonian University
RP Brzozowski, T (corresponding author), Jagiellonian Univ Med Coll, Dept Physiol, Fac Med, 16 Grzegorzecka St, PL-31531 Krakow, Poland.
EM aleksandradanielak26@gmail.com; dagmara1.wojcik@uj.edu.pl;
   agnieszka.mazur@uj.edu.pl; marcin.surmiak@uj.edu.pl;
   jan.bilski@uj.edu.pl; aneta.targosz@uj.edu.pl; m.magierowski@uj.edu.pl;
   anna.1.chmura@uj.edu.pl; malgorzata.strzalka@uj.edu.pl;
   gracjana98@gmail.com; katarzyna.magierowska@uj.edu.pl;
   urszula.szczyrk@uj.edu.pl; skwiecien@cm-uj.krakow.pl;
   agata.ptak-belowska@uj.edu.pl; mpbrzozo@cyf-kr.edu.pl
RI Mazur-Bialy, Agnieszka/I-4882-2012; Surmiak, Marcin/GYU-3390-2022;
   Magierowska, Katarzyna/LCE-2970-2024; Bilski, Jan/B-3412-2010;
   Magierowski, Marcin/AFO-9432-2022
OI Surmiak, Marcin/0000-0001-8396-1488; Mazur-Bialy,
   Agnieszka/0000-0003-1056-8276; Wojcik-Grzybek,
   Dagmara/0000-0003-3098-9617; Bilski, Jan/0000-0002-2699-3798; Chmura,
   Anna/0000-0001-5933-3158; Magierowski, Marcin/0000-0003-0175-5600
FU National Research Centre (NCN) in Poland [UMO-2015/19/B/NZ4/03130];
   Faculty of Health Sciences, Jagiellonian University Medical College,
   Cracow, Poland [N43/DBS/000149]
FX This work was supported by a grant (#UMO-2015/19/B/NZ4/03130) from the
   National Research Centre (NCN) in Poland and also received support from
   grant No. N43/DBS/000149 awarded by the Faculty of Health Sciences,
   Jagiellonian University Medical College, Cracow, Poland.
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NR 76
TC 9
Z9 10
U1 1
U2 14
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD FEB
PY 2021
VL 10
IS 2
AR 240
DI 10.3390/antiox10020240
PG 21
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA QM8ST
UT WOS:000622044600001
PM 33557311
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Stacchiotti, A
   Grossi, I
   García-Gómez, R
   Patel, GA
   Salvi, A
   Lavazza, A
   De Petro, G
   Monsalve, M
   Rezzani, R
AF Stacchiotti, Alessandra
   Grossi, Ilaria
   Garcia-Gomez, Raquel
   Patel, Gaurangkumar Arvindbhai
   Salvi, Alessandro
   Lavazza, Antonio
   De Petro, Giuseppina
   Monsalve, Maria
   Rezzani, Rita
TI Melatonin Effects on Non-Alcoholic Fatty Liver Disease Are Related to
   MicroRNA-34a-5p/Sirt1 Axis and Autophagy
SO CELLS
LA English
DT Article
DE melatonin; nonalcoholic fatty liver disease; SIRT1; microRNA-34a-5p;
   obesity
ID MITOCHONDRIAL DYSFUNCTION; HEPATOCELLULAR-CARCINOMA; SIRT1; EXPRESSION;
   DIET; GLUCOSE; ACID; STEATOSIS; MICRORNAS; PARTNER
AB Melatonin, an indole produced by pineal and extrapineal tissues, but also taken with a vegetarian diet, has strong anti-oxidant, anti-inflammatory and anti-obesogenic potentials. Non-alcoholic fatty liver disease (NAFLD) is the hepatic side of the metabolic syndrome. NAFLD is a still reversible phase but may evolve into steatohepatitis (NASH), cirrhosis and carcinoma. Currently, an effective therapy for blocking NAFLD staging is lacking. Silent information regulator 1 (SIRT1), a NAD+ dependent histone deacetylase, modulates the energetic metabolism in the liver. Micro-RNA-34a-5p, a direct inhibitor of SIRT1, is an emerging indicator of NAFLD grading. Thus, here we analyzed the effects of oral melatonin against NAFLD and underlying molecular mechanisms, focusing on steatosis, ER stress, mitochondrial shape and autophagy. Male C57BL/6J (WT) and SIRT1 heterozygous (HET) mice were placed either on a high-fat diet (58.4% energy from lard) (HFD) or on a standard maintenance diet (8.4% energy from lipids) for 16 weeks, drinking melatonin (10 mg/kg) or not. Indirect calorimetry, glucose tolerance, steatosis, inflammation, ER stress, mitochondrial changes, autophagy and microRNA-34a-5p expression were estimated. Melatonin improved hepatic metabolism and steatosis, influenced ER stress and mitochondrial shape, and promoted autophagy in WT HFD mice. Conversely, melatonin was ineffective in HET HFD mice, maintaining NASH changes. Indeed, autophagy was inconsistent in HET HFD or starved mice, as indicated by LC3II/LC3I ratio, p62/SQSTM1 and autophagosomes estimation. The beneficial role of melatonin in dietary induced NAFLD/NASH in mice was related to reduced expression of microRNA-34a-5p and sterol regulatory element-binding protein (SREBP1) but only in the presence of full SIRT1 availability.
C1 [Stacchiotti, Alessandra; Rezzani, Rita] Univ Brescia, Div Anat & Physiopathol, Dept Clin & Expt Sci, Viale Europa 11, I-25123 Brescia, Italy.
   [Stacchiotti, Alessandra; Rezzani, Rita] Univ Brescia, Interdipartmental Univ Ctr Res Adaptat & Regenera, I-25123 Brescia, Italy.
   [Grossi, Ilaria; Salvi, Alessandro; De Petro, Giuseppina] Univ Brescia, Dept Mol & Translat Med, Div Biol & Genet, I-25123 Brescia, Italy.
   [Garcia-Gomez, Raquel; Patel, Gaurangkumar Arvindbhai; Monsalve, Maria] UAM, CSIC, Inst Invest Biomed Alberto Sols, Madrid 28029, Spain.
   [Lavazza, Antonio] IZSLER, I-25124 Brescia, Italy.
C3 University of Brescia; University of Brescia; University of Brescia;
   Autonomous University of Madrid; Consejo Superior de Investigaciones
   Cientificas (CSIC); CSIC - Instituto de Investigaciones Biomedicas
   Alberto Sols (IIBM); IZS Lombardia e Emilia
RP Rezzani, R (corresponding author), Univ Brescia, Div Anat & Physiopathol, Dept Clin & Expt Sci, Viale Europa 11, I-25123 Brescia, Italy.; Rezzani, R (corresponding author), Univ Brescia, Interdipartmental Univ Ctr Res Adaptat & Regenera, I-25123 Brescia, Italy.
EM rita.rezzani@unibs.it
RI De Petro, Giuseppina/C-2719-2011; SALVI, Alessandro/AAB-7896-2019;
   Stacchiotti, Alessandra/AAA-2193-2019; GROSSI, Ilaria/AAA-4253-2019;
   Monsalve, Maria/K-4416-2014; lavazza, antonio/G-8182-2011
OI GROSSI, Ilaria/0000-0001-7768-0794; SALVI,
   Alessandro/0000-0001-6993-1565; Monsalve, Maria/0000-0003-2796-1453;
   Patel, Gaurangkumar/0000-0002-7495-809X; lavazza,
   antonio/0000-0002-7646-3592; De Petro, Giuseppina/0000-0001-9306-0851;
   Rezzani, Rita/0000-0002-7515-5846; Garcia Gomez,
   Raquel/0000-0002-3322-7477; stacchiotti, alessandra/0000-0002-6767-6617
FU FFABR 2017; University of Brescia (Italy); Spanish "Ministerio de
   Economia Industria y Competitividad" (MINEICO); FEDER funds
   [SAF2015-63904-R]; European Union's Horizon 2020 research and innovation
   programme under the Marie Sklodowska-Curie agreement [721236-TREATMENT]
FX This research was funded by FFABR 2017, 60% from grants of University of
   Brescia (Italy) and grants by the Spanish "Ministerio de Economia
   Industria y Competitividad" (MINEICO) including FEDER funds
   (SAF2015-63904-R) and the European Union's Horizon 2020 research and
   innovation programme under the Marie Sklodowska-Curie agreement
   721236-TREATMENT to M.M.
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NR 89
TC 60
Z9 62
U1 0
U2 15
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2073-4409
J9 CELLS-BASEL
JI Cells
PD SEP
PY 2019
VL 8
IS 9
AR 1053
DI 10.3390/cells8091053
PG 18
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA JC2JR
UT WOS:000489103800112
PM 31500354
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Toshihiro, M
   Saito, K
   Takikawa, S
   Takebe, N
   Onoda, T
   Satoh, J
AF Toshihiro, M.
   Saito, K.
   Takikawa, S.
   Takebe, N.
   Onoda, T.
   Satoh, J.
TI Psychosocial factors are independent risk factors for the development of
   Type 2 diabetes in Japanese workers with impaired fasting glucose and/or
   impaired glucose tolerance
SO DIABETIC MEDICINE
LA English
DT Article
DE impaired fasting glucose; impaired glucose tolerance; psychosocial
   factors; Type 2 diabetes
ID STRESSFUL LIFE EVENTS; METABOLIC SYNDROME; CARDIOVASCULAR-DISEASE;
   MYOCARDIAL-INFARCTION; DEPRESSIVE SYMPTOMS; CIGARETTE-SMOKING;
   ASSOCIATION; MELLITUS; PREVALENCE; ENZYMES
AB Aims We prospectively studied Japanese workers with impaired fasting glucose (IFG) and/or impaired glucose tolerance (IGT) and analysed possible risk factors for diabetes, including psychosocial factors such as stress.
   Methods The participants were 128 male Japanese company employees (mean age, 49.3 +/- 5.9 years) with IFG and/or IGT diagnosed by oral glucose tolerance test (OGTT). Participants were prospectively studied for 5 years with annual OGTTs. The Kaplan-Meier method and Cox's proportional hazard model were used to analyse the incidence of diabetes and the factors affecting glucose tolerance, including anthropometric, biochemical and social-psychological factors.
   Results Of 128 participants, 36 (28.1%) developed diabetes and 39 (30.5%) returned to normal glucose tolerance (NGT) during a mean follow-up of 3.2 years. Independent risk factors for diabetes were night duty [hazard ratio (HR) = 5.48, P = 0.002], higher fasting plasma glucose (FPG) levels within 6.1-6.9 mmol/l (HR = 1.05, P = 0.031), stress (HR = 3.81, P = 0.037) and administrative position (HR = 12.70, P = 0.045), while independent factors associated with recovery were lower FPG levels (HR = 0.94, P = 0.017), being a white-collar worker (HR = 0.34, P = 0.033), non-smoking (HR = 0.31, P = 0.040) and lower serum alanine aminotransferase (ALT) levels (HR = 0.97, P = 0.042).
   Conclusions In addition to FPG levels at baseline, psychosocial factors (night duty, stress and administrative position) are risk factors for Type 2 diabetes, while being a white-collar worker, a non-smoker and lower serum ALT levels are factors associated with return to NGT in Japanese workers with IFG and/or IGT.
C1 [Toshihiro, M.; Takebe, N.; Satoh, J.] Iwate Med Univ, Dept Diabet & Metab, Morioka, Iwate 0208505, Japan.
   [Saito, K.; Takikawa, S.] Iwate Med Univ, Nishimatsuzono Clin Internal Med, Morioka, Iwate 0208505, Japan.
   [Onoda, T.] Iwate Med Univ, Dept Publ Hlth, Morioka, Iwate 0208505, Japan.
C3 Iwate Medical University; Iwate Medical University; Iwate Medical
   University
RP Satoh, J (corresponding author), Iwate Med Univ, Dept Diabet & Metab, 19-1 Uchimaru, Morioka, Iwate 0208505, Japan.
EM jsatoh@iwate-med.ac.jp
FU Japanese Ministry of Education, Culture, Sports, Science and Technology
   (MEXT)
FX This research was supported by the 'Open Research Center' Project for
   Private Universities, a matching fund subsidy from the Japanese Ministry
   of Education, Culture, Sports, Science and Technology (MEXT), 2004-2008
   and by a research fund from Iwate Prefecture. We thank Dr N Nakamura for
   helpful advice.
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NR 36
TC 46
Z9 48
U1 0
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0742-3071
EI 1464-5491
J9 DIABETIC MED
JI Diabetic Med.
PD OCT
PY 2008
VL 25
IS 10
BP 1211
EP 1217
DI 10.1111/j.1464-5491.2008.02566.x
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 356YX
UT WOS:000259814600011
PM 19046200
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Gelaleti, RB
   Damasceno, DC
   Salvadori, DMF
   Marcondes, JPC
   Lima, PHO
   Morceli, G
   Calderon, IMP
   Rudge, MVC
AF Gelaleti, Rafael B.
   Damasceno, Debora C.
   Salvadori, Daisy M. F.
   Marcondes, Joao Paulo C.
   Lima, Paula H. O.
   Morceli, Glilciane
   Calderon, Iracema M. P.
   Rudge, Marilza V. C.
TI IRS-1 gene polymorphism and DNA damage in pregnant women
   with diabetes or mild gestational hyperglycemia
SO DIABETOLOGY & METABOLIC SYNDROME
LA English
DT Article
DE Diabetes; Mild gestational hyperglycemia; Pregnancy; Newborn;
   Polymorphism; DNA damage
ID INSULIN-RECEPTOR SUBSTRATE-1; MATERNAL DAILY HYPERGLYCEMIA; METABOLIC
   SYNDROME; OXIDATIVE STRESS; NO EVIDENCE; RESISTANCE; VARIANT; OBESITY;
   ASSOCIATION; ANTIOXIDANT
AB Background: Pregnant women with mild gestational hyperglycemia present a high risk for hypertension and obesity, and appear to reproduce the model of metabolic syndrome in pregnancy, including hyperinsulinemia and insulin resistance. Diabetic patients have a higher frequency of the IRS-1 Gly972Arg variant and this polymorphism is directly related to insulin resistance and subsequent hyperglycemia. In diabetes, hyperglycemia and other associated factors generate reactive oxygen species that increase DNA damage. The aims of this study were to evaluate the presence of the IRS-1 Arg972 polymorphism in pregnant women with diabetes or mild gestational hyperglycemia, and in their newborns. Additionally, we evaluated the level of primary DNA damage in lymphocytes of Brazilian pregnant women and the relationship between the amount of genetic damage and presence of the polymorphism.
   Methods: A based on the oral glucose tolerance test (OGTT) results and on glycemic profiles (GP), as follows: nondiabetic group, mild gestational hyperglycemia (MGH) and diabetic group. Eighty-five newborns were included in the study. Maternal peripheral blood samples and umbilical cord blood samples (5-10 mL) were collected for genotyping by PCR-RFLP and for comet assays.
   Results: The prevalence of genotype Gly/Arg in pregnant women groups was not statistically significant. In newborns, the frequency of Gly/Arg was significantly higher in the MGH and diabetic groups than in the non-diabetic group. Taken together, groups IIA and IIB (IIA + IIB; diabetes) presented lower amounts of DNA damage than the non-diabetic group (p = 0.064). No significant association was detected between genetic damage and the presence of the Arg972 genotype in pregnant women.
   Conclusion: The polymorphism was more prevalent in newborns of diabetic and MGH women. We believe that it is necessary to increase the number of subjects to be examined in order to better determine the biological role of the Arg972 polymorphism in these patients. Despite being classified as low-risk, pregnant women with mild gestational hyperglycemia characterize a population of maternal and perinatal adverse outcomes, and that, together with their newborns, require better monitoring by professionals and health services.
C1 [Gelaleti, Rafael B.; Damasceno, Debora C.; Lima, Paula H. O.; Morceli, Glilciane; Calderon, Iracema M. P.; Rudge, Marilza V. C.] Unesp Univ Estadual Paulista, Lab Expt Res Gynecol & Obstet, Dept Gynecol & Obstet, Botucatu Med Sch, BR-18618000 Sao Paulo, Brazil.
   [Salvadori, Daisy M. F.; Marcondes, Joao Paulo C.] Unesp Univ Estadual Paulista, Dept Pathol, Lab Toxigen & Nutrigen, Botucatu Med Sch, Botucatu, SP, Brazil.
C3 Universidade Estadual Paulista; Universidade Estadual Paulista
RP Gelaleti, RB (corresponding author), Unesp Univ Estadual Paulista, Lab Expt Res Gynecol & Obstet, Dept Gynecol & Obstet, Botucatu Med Sch, Dist Rubiao Junior S-N, BR-18618000 Sao Paulo, Brazil.
EM rafaelgelaleti@hotmail.com; marilzarudge@gmail.com
RI Lima, Paula/H-3559-2015; Rudge, Marilza/S-9057-2018; Calderon,
   Iracema/W-4336-2019; Marcondes, Joao Paulo/G-6980-2012; Calderon,
   Iracema/C-8136-2012; Gelaleti, Rafael/F-5664-2012; Morceli,
   Glilciane/C-7487-2012; FAVERO SALVADORI, DAISY MARIA/E-7744-2012; Vieira
   Cunha Rudge, Marilza/C-8338-2012; Damasceno, Debora Cristina/C-7234-2012
OI Marcondes, Joao Paulo/0000-0002-5116-2494; Calderon,
   Iracema/0000-0003-4761-4336; Ortiz Lima, Paula
   Helena/0000-0002-0631-8074; Gelaleti, Rafael/0000-0002-6098-9899;
   Morceli, Glilciane/0000-0001-8216-9931; FAVERO SALVADORI, DAISY
   MARIA/0000-0001-9323-3134; Vieira Cunha Rudge,
   Marilza/0000-0002-9227-832X; Damasceno, Debora
   Cristina/0000-0002-7003-9643
FU FAPESP - Fundacao de Amparo a Pesquisa do Estado de Sao Paulo/Brazil
   [2008/06642-6, 2008/06480-6]; Swedish Research Council [2008-06642]
   Funding Source: Swedish Research Council
FX The authors are thankful to the staff of the Laboratory for Experimental
   Research in Gynecology and Obstetrics and to Talisia Moretto for their
   technical contribution, and to the Research Support Center (GAP) of
   Botucatu Medical School, Unesp, for assisting with statistical analyses.
   This study was supported by FAPESP - Fundacao de Amparo a Pesquisa do
   Estado de Sao Paulo/Brazil (Grant number 2008/06642-6 and 2008/06480-6).
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NR 47
TC 7
Z9 8
U1 0
U2 8
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1758-5996
J9 DIABETOL METAB SYNDR
JI Diabetol. Metab. Syndr.
PD APR 2
PY 2015
VL 7
AR 30
DI 10.1186/s13098-015-0026-3
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA CF5IU
UT WOS:000352591500001
PM 25859280
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Sachdeva, AK
   Dharavath, RN
   Chopra, K
AF Sachdeva, Anand Kamal
   Dharavath, Ravinder Naik
   Chopra, Kanwaljit
TI Time-response studies on development of cognitive deficits in an
   experimental model of insulin resistance
SO CLINICAL NUTRITION
LA English
DT Article
DE Insulin resistance; Cognitive deficits; Metabolic syndrome; Fructose
   feeding; Neuroinflammation
ID FRUCTOSE-DRINKING RATS; OXIDATIVE STRESS; ACETYLCHOLINESTERASE ACTIVITY;
   ALZHEIMER-DISEASE; MEMORY DEFICITS; BRAIN; METABOLISM; BETA;
   HYPERTRIGLYCERIDEMIA; PIOGLITAZONE
AB Background & Aims: Alzheimer's disease is suggested to be primarily metabolic, mainly characterized by brain insulin resistance. Chronic fructose feeding results in hippocampal insulin resistance. However, variable opinion exists regarding the concentration and duration of fructose feeding to trigger insulin resistance and resultant cognitive insults. Therefore this study was planned to construct a time response curve of the appearance of fructose-induced insulin resistance and memory insufficiencies in rats over a period of 24 weeks. Further, Pearson's correlations were drawn between indices of insulin resistance and markers of memory deficits at various time points.
   Methods: Male Wistar rats (6 weeks old; 155 5 g) were fed with 15% fructose in normal drinking water for a period of 24 weeks. Body weight, food and water intake were weekly monitored. Fasting blood glucose, glycosylated hemoglobin (HbA(1C), lipid profiling, plasma insulin, HOMA-IR index, and systolic blood pressure were estimated to confirm the manifestation of insulin resistance. Cognitive derangements were evaluated by Elevated plus maze and Morris water maze at different time points during the study.
   Results: Most of the parameters including insulin resistance became evident at the 7th week and continued until the end of study (24th week) whereas cognitive insufficiency became significantly distinct at the 20th, 22nd and 24th week. Significantly increased serum nitro-oxidative stress, inflammatory cytokines and serum homocysteine levels were intensely connected with fructose-induced neuronal deficits.
   Conclusions: The construction of time response study reveals that the hallmark characteristics of insulin resistance appear from the 7th week of fructose feeding whereas the cognitive dysfunction appears on the 20th week and both persist till the end of the study. Fructose-induced oxidative stress and neuroinflammation plausibly impair neuronal signaling and synaptic plasticity. (C) 2018 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.
C1 [Sachdeva, Anand Kamal; Dharavath, Ravinder Naik; Chopra, Kanwaljit] Panjab Univ, UGC Ctr Adv Study, Univ Inst Pharmaceut Sci, Pharmacol Res Lab, Chandigarh 160014, India.
C3 Panjab University
RP Chopra, K (corresponding author), Panjab Univ, UGC Ctr Adv Study, Univ Inst Pharmaceut Sci, Pharmacol Res Lab, Chandigarh 160014, India.
EM dr_chopra_k@yahoo.com
RI Dharavath, Ravinder Naik/AAB-9469-2019
OI Chopra, Kanwaljit/0000-0001-5898-6093; Dharavath, Ravinder
   Naik/0000-0002-2356-2458
FU Council of Scientific and Industrial Research (CSIR); Ministry of
   Science & Technology, India [09/135/0654/2012- EMR-I]; University Grants
   Commission (UGC), India [39-156/2010]
FX The authors would like to acknowledge Council of Scientific and
   Industrial Research (CSIR), Ministry of Science & Technology (Grant:
   09/135/0654/2012- EMR-I), India for providing a Senior Research
   Fellowship to Dr. Anand Kamal Sachdeva and University Grants Commission
   (UGC) (Grant: Kanwaljit Chopra, PI UGC-MRP, 39-156/2010), India for
   funding this work.
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NR 51
TC 18
Z9 20
U1 1
U2 9
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0261-5614
EI 1532-1983
J9 CLIN NUTR
JI Clin. Nutr.
PD JUN
PY 2019
VL 38
IS 3
BP 1447
EP 1456
DI 10.1016/j.clnu.2018.06.966
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA IA9QL
UT WOS:000469891800058
PM 30037709
DA 2025-06-11
ER

PT J
AU Villagarcía, HG
   Castro, MC
   Arbelaez, LG
   Schinella, G
   Massa, ML
   Spinedi, E
   Francini, F
AF Gonzalo Villagarcia, Hernan
   Cecilia Castro, Maria
   Gonzalez Arbelaez, Luisa
   Schinella, Guillermo
   Laura Massa, Maria
   Spinedi, Eduardo
   Francini, Flavio
TI N-Acetyl-L-Cysteine treatment efficiently prevented pre-diabetes
   and inflamed-dysmetabolic liver development in hypothalamic obese rats
SO LIFE SCIENCES
LA English
DT Article
DE Antioxidant; Oxidative stress; Metabolic syndrome; Insulin-resistance;
   Liver dysfunction; MSG-damaged rat
ID NITRIC-OXIDE SYNTHASE; POLYCYSTIC-OVARY-SYNDROME; MONOSODIUM GLUTAMATE;
   OXIDATIVE STRESS; INSULIN-RESISTANCE; 3T3-L1 ADIPOCYTES; ADIPOSE-TISSUE;
   ENDOTHELIAL FUNCTION; METABOLIC-DISORDERS; ARCUATE NUCLEUS
AB Aim: Hypothalamic obese rats are characterized by pre-diabetes, dyslipidemia, hyperadiposity, inflammation and, liver dysmetabolism with oxidative stress (OS), among others. We studied endocrine-metabolic dysfunctions and, liver OS and inflammation in both monosodium L-glutamate (MSG)-neonatally damaged and control litter-mate (C) adult male rats, either chronically treated with N-Acetyl-L-Cysteine since weaned (C-NAC and MSG-NAC) or not.
   Methodology: We evaluated circulating TBARS, glucose, insulin, triglycerides, uric acid (UA) and, aspartate and alanine amino-transferase; insulin sensitivity markers (HOMA indexes, Liver Index of Insulin Sensitivity -LISI-) were calculated and liver steps of the insulin-signaling pathway were investigated. Additionally, we monitored liver OS (protein carbonyl groups, GSH and iNOS level) and inflammation-related markers (COX-2 and TNF alpha protein content; gene expression level of Il1b, Tnfa and Pai-1); and carbohydrate and lipid metabolic functions (glucokinase/fructokinase activities and, mRNA levels of Srebp1c, Fas and Gpat).
   Key Findings: Chronic NAC treatment in MSG rats efficiently decreased the high circulating levels of triglycerides, UA, transaminases and TBARS, as well as peripheral (high insulinemia and HOMA indexes) and liver (LISI and the P-AKT: AKT and P-eNOS: eNOS protein ratio values) insulin-resistance. Moreover, NAC therapy in MSG rats prevented liver dysmetabolism by decreasing local levels of OS and inflammation markers. Finally, NAC-treated MSG rats retained normal liver glucokinase and fructokinase activities, and Srebp1c, Fas and Gpat (lipogenic genes) expression levels.
   Significance: Our study strongly supports that chronic oral antioxidant therapy (NAC administration) prevented the development of pre-diabetes, dyslipidemia, and inflamed-dysmetabolic liver in hypothalamic obese rats by efficiently decreasing high endogenous OS.
C1 [Gonzalo Villagarcia, Hernan; Cecilia Castro, Maria; Laura Massa, Maria; Spinedi, Eduardo; Francini, Flavio] CENEXA Ctr Endocrinol Expt & Aplicada, La Plata, Buenos Aires, Argentina.
   [Gonzalo Villagarcia, Hernan; Cecilia Castro, Maria; Laura Massa, Maria; Spinedi, Eduardo; Francini, Flavio] UNLP, CONICET, FCM, CEAS,CICPBA, La Plata, Buenos Aires, Argentina.
   [Gonzalez Arbelaez, Luisa] CIC, La Plata, Buenos Aires, Argentina.
   [Gonzalez Arbelaez, Luisa] UNLP, CONICET, FCM, La Plata, Buenos Aires, Argentina.
   [Schinella, Guillermo] UNLP, Fac Ciencias Med, Catedra Farmacol Basica, RA-1900 La Plata, Buenos Aires, Argentina.
   [Schinella, Guillermo] CICPBA, RA-1900 La Plata, Buenos Aires, Argentina.
C3 Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET);
   National University of La Plata; Consejo Nacional de Investigaciones
   Cientificas y Tecnicas (CONICET); National University of La Plata;
   National University of La Plata
RP Francini, F (corresponding author), UNLP, CONICET, FCM, CENEXA, RA-1900 La Plata, Buenos Aires, Argentina.
EM f_francini@yahoo.com
RI Schinella, Guillermo/V-9937-2018
OI Schinella, Guillermo/0000-0001-9541-9688; CASTRO, MARIA
   CECILIA/0000-0003-0831-4111
FU National Research Council of Argentina (CONICET); CONICET
   [PIP-0181-2014]; Swiss Foundation for Studies on Endocrinology,
   Diabetology and Metabolism [FPREDM 052015]
FX Authors are grateful to Susan H Rogers for careful manuscript
   edition/correction and to ME Garcia for performing TBARS measurements.
   MLM, MCC, ES and FF are Research Career Awardees from the National
   Research Council of Argentina (CONICET). This work was partially
   supported by grants from CONICET (PIP-0181-2014) and the Swiss
   Foundation for Studies on Endocrinology, Diabetology and Metabolism
   (FPREDM 052015).
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NR 67
TC 13
Z9 14
U1 0
U2 13
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0024-3205
EI 1879-0631
J9 LIFE SCI
JI Life Sci.
PD APR 15
PY 2018
VL 199
BP 88
EP 95
DI 10.1016/j.lfs.2018.03.008
PG 8
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA GC3DO
UT WOS:000429664700011
PM 29522769
OA Green Published
DA 2025-06-11
ER

PT J
AU Côté, N
   Pibarot, P
   Pépin, A
   Fournier, D
   Audet, A
   Arsenault, B
   Couture, C
   Poirier, P
   Després, JP
   Mathieu, P
AF Cote, Nancy
   Pibarot, Philippe
   Pepin, Andree
   Fournier, Dominique
   Audet, Audrey
   Arsenault, Benoit
   Couture, Christian
   Poirier, Paul
   Despres, Jean-Pierre
   Mathieu, Patrick
TI Oxidized low-density lipoprotein, angiotensin II and increased waist
   cirumference are associated with valve inflammation in prehypertensive
   patients with aortic stenosis
SO INTERNATIONAL JOURNAL OF CARDIOLOGY
LA English
DT Article
DE Prehypertension; Aortic stenosis; Oxidized-LDL; Angiotensin II
ID CARDIOVASCULAR-DISEASE RISK; INSULIN-RESISTANCE; CONVERTING ENZYME;
   OXIDATIVE STRESS; BLOOD-PRESSURE; HEART-DISEASE; HYPERTENSION;
   HYPERCHOLESTEROLEMIA; ATHEROSCLEROSIS; PROGRESSION
AB Introduction: The progression of aortic stenosis (AS) has been shown to be faster in patients with the metabolic syndrome. We sought to determine the relationships between blood pressure, inflammation, oxidative stress and valvular inflammation in a population of normotensive and prehypertensive patients with AS.
   Methods: In this study, 36 male patients (age: 61.5 +/- 2 years) with AS undergoing an aortic valve replacement were investigated. Plasma levels of adiponectin, oxidized-LDL (ox-LDL), angiotensinogen (AGN) and angiotensin I-II (Ang I-II) were measured. On explanted aortic valves, immunohistochemistry studies and quantitative PCR (q-PCR) analyses were performed to document the expression of inflammatory cytokines.
   Results: Systolic blood pressure (SBP) was positively correlated with plasma level of ox-LDL (r = 0.4; p = 0.02), AGN (r = 0.41; p = 0.01), and white blood cells count (r = 0.33; p = 0.04), whereas it was inversely related to plasma level of adiponectin (r = -.35; p = 0.04). After adjustment for covariates, plasma level of ox-LDL (p = 0.01) remained significantly associated with SBP (p = 0.01). Within the aortic valve, expression of TNF-alpha was significantly associated with plasma levels of ox-LDL (r = 0.58; p = 0.03), Ang II (r = 0.69; p = 0.013), and waist circumference (r = 0.60; p = 0.02), whereas valvular expression of IL-6 was associated with plasma level of Ang II (r = 0.51; p = 0.03). In explanted AS valves, ox-LDL was documented near calcified areas and colocalized with Ang II, IL-6, and TNF-alpha.
   Conclusion: Conditions associated with a higher oxidative stress and activation of the renin angiotensin system, such as encountered in viscerally obese and prehypertensive patients, contribute to higher valvular inflammation in AS. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
C1 [Cote, Nancy; Pepin, Andree; Fournier, Dominique; Audet, Audrey; Mathieu, Patrick] Univ Laval, Dept Surg, Laval Hosp, LEMV,Res Ctr,Quebec Heart Inst, Quebec City, PQ G1V 4G5, Canada.
   [Arsenault, Benoit; Despres, Jean-Pierre] Univ Laval, Dept Social & Prevent Med, Div Kinesiol, Quebec City, PQ G1V 4G5, Canada.
   [Pibarot, Philippe] Univ Laval, Dept Med, Quebec City, PQ G1V 4G5, Canada.
   [Poirier, Paul] Univ Laval, Dept Pharm, Quebec City, PQ G1V 4G5, Canada.
   [Couture, Christian] Univ Laval, Dept Pathol, Quebec City, PQ G1V 4G5, Canada.
C3 Laval University; Laval University; Laval University; Laval University;
   Laval University
RP Mathieu, P (corresponding author), Univ Laval, Dept Surg, Laval Hosp, LEMV,Res Ctr,Quebec Heart Inst, 2725 Chemin Ste Foy, Quebec City, PQ G1V 4G5, Canada.
EM patrick.mathieu@chg.ulaval.ca
RI Côté, Nancy/JXM-6224-2024; Poirier, Paul/KFS-2253-2024; Pibarot,
   Philippe/ABD-5300-2021
FU Canadian Institute of Health Research (CIHR), Ottawa, Canada [79342];
   Quebec Heart Institute Foundation; Reseau d'Echanges et de Tissus
   Biologiques, Fonds de Recherche en Sante du Quebec, Montreal;
   Sanofi-Aventis; Academy of Finland (AKA) [79342] Funding Source: Academy
   of Finland (AKA)
FX This work was supported by the Canadian Institute of Health Research
   (CIHR), Ottawa, Canada; grant number 79342, the Quebec Heart Institute
   Foundation, and the Reseau d'Echanges et de Tissus Biologiques, Fonds de
   Recherche en Sante du Quebec, Montreal. Dr. Pibarot holds the Canada
   Research Chair in Valvular Heart Diseases, Canadian Institutes of Health
   Research, Ottawa, Ontario, Canada. Dr. Despres is the scientific
   director of the International Chair on Cardiometabolic Risk at
   University Laval, which is supported by an unrestricted grant from
   Sanofi-Aventis. Dr. Mathieu and Dr. Poirier are research scholars from
   the Fonds de Recherches en Sante du Quebec, Montreal, Canada.
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NR 32
TC 38
Z9 43
U1 0
U2 3
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0167-5273
EI 1874-1754
J9 INT J CARDIOL
JI Int. J. Cardiol.
PD DEC 3
PY 2010
VL 145
IS 3
BP 444
EP 449
DI 10.1016/j.ijcard.2009.05.054
PG 6
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 692EU
UT WOS:000285136200021
PM 19525020
DA 2025-06-11
ER

PT J
AU Kassi, E
   Dalamaga, M
   Hroussalas, G
   Kazanis, K
   Merantzi, G
   Zachari, A
   Giamarellos-Bourboulis, EJ
   Dionyssiou-Asteriou, A
AF Kassi, E.
   Dalamaga, M.
   Hroussalas, G.
   Kazanis, K.
   Merantzi, G.
   Zachari, A.
   Giamarellos-Bourboulis, E. J.
   Dionyssiou-Asteriou, A.
TI Adipocyte factors, high-sensitive C-reactive protein levels and
   lipoxidative stress products in overweight postmenopausal women with
   normal and impaired OGTT
SO MATURITAS
LA English
DT Article
DE Obesity; Menopause; Leptin; Adiponectin; Malondialdehyde; Oxidized LDL
ID NECROSIS-FACTOR-ALPHA; METABOLIC SYNDROME; OXIDATIVE STRESS;
   INSULIN-RESISTANCE; ADIPONECTIN LEVELS; GLUCOSE-TOLERANCE;
   ADIPOSE-TISSUE; OXIDIZED LDL; OBESE WOMEN; LEPTIN
AB Objective: In obese postmenopausal women we assessed leptin and adiponectin, high-sensitive C-reactive protein (hsCRP), serum lipids and lipoxidative stress products: oxidized LDL (oxLDL) and malondialdehyde (MDA), in relation to impaired glucose tolerance (IGT).
   Methods: Thirty-eight overweight/obese postmenopausal women were included in the study. Eighteen with normal glucose metabolism (NGT) and twenty with IGT, as it is diagnosed by OGTT. Serum leptin, adiponectin, hsCRP and MDA were measured at time 0 and 120 min of OGTT while total-cholesterol, LDL, HDL, triglycerides, oxLDL and anti-oxLDL autoantibodies at time 0. Insulin resistance (HOMA)/sensitivity (QUICK!) indexes were estimated.
   Results: In subjects with NGT, hsCRP was positively correlated with fasting leptin and HOMA, while in subjects with IGT negatively with QUICKI. In both groups, hsCRP was positively correlated with fasting insulin, body mass index and waist circumference. Fasting adiponectin was positively associated with HDL in both groups and negatively with triglycerides in subjects with NGT as well as with serum glucose levels at time 120 min of OGTT in subjects with IGT. No association was observed between oxLDL and adipokines. A significant positive association was found between oxLDL and HOMA in subjects with IGT. During OGTT there was a significant increase of leptin and MDA levels in both groups.
   Conclusions: A relationship exists between obesity, insulin and sub-clinical inflammation. Leptin and lipid peroxidation are linked to hyperglycaemic state while oxLDL might be considered as a predictor of insulin resistance. Adiponectin could exert its antiatherogenic effect through HDL independently of the presence of IGT. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
C1 [Kassi, E.; Dalamaga, M.; Hroussalas, G.; Kazanis, K.; Dionyssiou-Asteriou, A.] Univ Athens, Dept Clin Biochem, Sch Med, GR-10679 Athens, Greece.
   [Merantzi, G.] Evangelismos Gen Hosp, Biochem Lab, Athens, Greece.
   [Zachari, A.; Dionyssiou-Asteriou, A.] Univ Athens, Dept Biol Chem, Sch Med, GR-10679 Athens, Greece.
   [Giamarellos-Bourboulis, E. J.] Univ Athens, Dept Internal Med 4, Sch Med, GR-10679 Athens, Greece.
C3 National & Kapodistrian University of Athens; Athens Medical School;
   Evangelismos Hospital; National & Kapodistrian University of Athens;
   Athens Medical School; National & Kapodistrian University of Athens;
   Athens Medical School
RP Dionyssiou-Asteriou, A (corresponding author), 11 Korinthou Str, Athens 14564, Greece.
EM madalamaga@med.uoa.gr
RI Giamarellos-Bourboulis, Evangelos/AAD-7155-2019; Kassi, Eva/G-1278-2011;
   Dalamaga, Maria/A-4041-2013
OI Giamarellos-Bourboulis, Evangelos/0000-0003-4713-3911; Dalamaga,
   Maria/0000-0002-7008-388X
FU University of Athens
FX This work was supported by the Special Research Accounts of the
   University of Athens.
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NR 42
TC 26
Z9 26
U1 0
U2 2
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0378-5122
EI 1873-4111
J9 MATURITAS
JI Maturitas
PD SEP
PY 2010
VL 67
IS 1
BP 72
EP 77
DI 10.1016/j.maturitas.2010.05.004
PG 6
WC Geriatrics & Gerontology; Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology; Obstetrics & Gynecology
GA 651QU
UT WOS:000281943000015
PM 20570453
DA 2025-06-11
ER

PT J
AU Corbould, A
AF Corbould, A.
TI Insulin resistance in skeletal muscle and adipose tissue in polycystic
   ovary syndrome: are the molecular mechanisms distinct from type 2
   diabetes?
SO PANMINERVA MEDICA
LA English
DT Review
DE Insulin resistance; Polycystic ovary syndrome; Diabetes mellitus, type
   2; Muscle, skeletal; Adipocytes
ID IMPAIRED GLUCOSE-TOLERANCE; ENDOPLASMIC-RETICULUM STRESS; INCREASED
   OXIDATIVE STRESS; GTPASE-ACTIVATING PROTEIN; GENE-EXPRESSION PROFILE;
   AKT/PROTEIN KINASE-B; RECEPTOR SUBSTRATE-1; METABOLIC SYNDROME;
   CARDIOVASCULAR-DISEASE; ANDROGEN EXCESS
AB The association of polycystic ovary syndrome (PCOS) with insulin resistance was recognized almost three decades ago. Despite the pivotal role of insulin resistance in the pathogenesis of PCOS, the precise cellular and molecular mechanisms of impaired insulin action remain elusive. This review has two aims: 1) to review the mechanisms of insulin resistance, specifically impaired insulin-stimulated glucose transport, in skeletal muscle and adipose tissue in PCOS, and 2) to assess whether mechanisms of insulin resistance in PCOS are distinct from those in type 2 diabetes. As in type 2 diabetes, studies in skeletal muscle in PCOS support the existence of intrinsic defects in insulin signalling but also underscore the importance of in vivo environmental factors for the development of insulin resistance. In PCOS and type 2 diabetes, similar insulin signalling defects in muscle have been described i.e. impaired signalling via IRS-1 and up-regulation of ERK signalling. Similar defects in insulin signalling have also been (described in adipose tissue in PCOS and type 2 diabetes, but data are limited. As for type 2 diabetes, PCOS is characterized by chronic inflammation, mitochondrial dysfunction and cellular stress. Androgen excess, a key feature of PCOS, has a genetic component: the relationship of hyperandrogenemia to the development or insulin resistance requires further study. In conclusion, although similar insulin signalling defects have been identified in muscle and adipose tissue in PCOS and type 2 diabetes, these defects probably reflect a common final pathway resulting from genetic and environmental influences on insulin action that tire unique to each disorder.
C1 Prince Henrys Inst Med Res, Monash Med Ctr, Clayton, Vic 3168, Australia.
C3 Prince Henry's Institute of Medical Research; Monash University; Monash
   Health; Monash Medical Centre
RP Corbould, A (corresponding author), Prince Henrys Inst Med Res, Monash Med Ctr, Block E,Level 4,Clayton Rd, Clayton, Vic 3168, Australia.
EM anne.corbould@princehenrys.org
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NR 129
TC 21
Z9 23
U1 0
U2 7
PU EDIZIONI MINERVA MEDICA
PI TURIN
PA CORSO BRAMANTE 83-85 INT JOURNALS DEPT., 10126 TURIN, ITALY
SN 0031-0808
EI 1827-1898
J9 PANMINERVA MED
JI Panminerva Medica
PD DEC
PY 2008
VL 50
IS 4
BP 279
EP 294
PG 16
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 412DZ
UT WOS:000263705100002
PM 19078869
DA 2025-06-11
ER

PT J
AU Baptista, T
   Serrano, A
   Uzcátegui, E
   ElFakih, Y
   Rangel, N
   Carrizo, E
   Fernández, V
   Connell, L
   de Baptista, EA
   Quiroz, S
   Uzcátegui, M
   Rondón, J
   Matos, Y
   Uzcátegui, L
   Gómez, R
   Valery, L
   Novoa-Montero, D
AF Baptista, Trino
   Serrano, Ana
   Uzcategui, Euderruh
   ElFakih, Yamily
   Rangel, Nairy
   Carrizo, Edgardo
   Fernandez, Virginia
   Connell, Lisette
   Araujo de Baptista, Enma
   Quiroz, Segundo
   Uzcategui, Marycelvia
   Rondon, Juana
   Matos, Yimber
   Uzcategui, Lilia
   Gomez, Roald
   Valery, Lenin
   Novoa-Montero, Dario
TI The metabolic syndrome and its constituting variables in atypical
   antipsychotic-treated subjects: Comparison with other drug treatments,
   drug-free psychiatric patients, first-degree relatives and the general
   population in Venezuela
SO SCHIZOPHRENIA RESEARCH
LA English
DT Article
DE Cholesterol; Epidemiology; Glucose; Triglycerides; Obesity; Psychiatric
   patients
ID INDUCED WEIGHT-GAIN; BIPOLAR DISORDER; 2ND-GENERATION ANTIPSYCHOTICS;
   RISK-FACTORS; SCHIZOPHRENIA; PREVALENCE; MECHANISMS; CONSENSUS; OBESITY
AB Background: Few studies on the association between atypical antipsychotic drug (AAP) administration and metabolic dysfunction have concurrently evaluated the general population (GP), other psychotropic drug treatments and drug-free psychiatric patients.
   Methods: We assessed the frequency of the metabolic syndrome (MS) according to the National Cholesterol Education Program criteria (NCEP) and its constituting variables in a GP sample (n = 271) and in patients receiving, for at least three consecutive months, antiepileptic drugs (n = 93), olanzapine (n = 162), clozapine (n = 105), typical antipsychotics (n = 117), other AAP (n = 58), other psychotropic drugs (n= 185), and drug-free individuals (n = 636). Subjects were clinically classified as schizophrenia, bipolar or other axis I disorders (DSM-IV-RT), and as first-degree relatives of each diagnostic group.
   Results: The MS was detected in 26.6% of the GP (95% confidence interval: 21.5-31.8). No diagnostic or treatment group had a significantly higher age-adjusted frequency than the GP (p > 0.05). Treatment duration did not significantly affect the results. However, significant differences were observed in the frequency of abnormal MS constituting variables in comparison to the GP. For example, schizophrenia patients and their relatives, bipolar subjects and olanzapine- and clozapine-treated patients had higher abnormal waist circumference values. In addition, bipolar patients and their relatives and subjects treated with olanzapine and other AAPs had higher frequencies of abnormal glucose levels. Neither schizophrenia nor bipolar patients in the diagnostic categories nor the olanzapine or the clozapine groups displayed higher proportions of abnormal triglycerides, high density cholesterol or blood pressure levels than the GP.
   Conclusions: While we did not demonstrate an increased frequency of the MS in AAP-treated subjects, our results confirm that specific metabolic variables must be monitored in psychiatric patients. Besides they stress the importance, in epidemiological studies, of concurrently comparing the figures recorded in AAP-treated patients with those obtained in the local GP, other drug treatment groups and drug-free subjects when referring to the magnitude of the metabolic effects of specific antipsychotic agents. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Baptista, Trino] Univ Los Andes, Sch Med, Dept Physiol, Merida 5101A, Venezuela.
   [Serrano, Ana; Uzcategui, Euderruh; ElFakih, Yamily] Univ Los Andes, Sch Med, Dept Psychiat, Merida 5101A, Venezuela.
   [Rangel, Nairy] Dr Raul Castillo Psychiat Rehabil Inst, Peribeca, Tachira, Venezuela.
   [Carrizo, Edgardo; Fernandez, Virginia; Connell, Lisette] Univ Zulia, Sch Med, Dr Americo Negrette Inst Clin Invest, Maracaibo 4011, Zulia, Venezuela.
   [Araujo de Baptista, Enma] Univ Los Andes, Sch Pharm, Dept Microbiol, Merida 5101A, Venezuela.
   [Quiroz, Segundo; Valery, Lenin] Univ Los Andes, Sch Econ & Social Sci, Merida 5101A, Venezuela.
   [Uzcategui, Marycelvia] San Juan de Dios Hosp, Merida, Venezuela.
   [Rondon, Juana] Univ Los Andes, Sch Med, Dept Physiopathol, Merida 5101A, Venezuela.
   [Matos, Yimber] Univ Los Andes, Sch Med, Dept Neurol, Merida 5101A, Venezuela.
   [Uzcategui, Lilia; Gomez, Roald] Univ Los Andes, Sch Med, Dept Endocrinol, Merida 5101A, Venezuela.
   [Novoa-Montero, Dario] Univ Los Andes, Lab Interdisciplinario Invest Clin Epidemiol LABM, Merida 5101A, Venezuela.
C3 University of Los Andes Venezuela; University of Los Andes Venezuela;
   University of Los Andes Venezuela; University of Los Andes Venezuela;
   University of Los Andes Venezuela; University of Los Andes Venezuela;
   University of Los Andes Venezuela; University of Los Andes Venezuela
RP Baptista, T (corresponding author), Univ Los Andes, Sch Med, Dept Physiol, POB 93, Merida 5101A, Venezuela.
EM trinbap@yahoo.com
OI Matos, Yimber/0000-0002-3653-9134
FU FONACIT; Caracas; Venezuela [G-2005-000-384]; CDCH-T, Los Andes
   University [M-794-04-07-B]
FX Government of Venezuela, FONACIT, Caracas. Only provided funds. It did
   not participate in design, procedure, data analysis and manuscript
   presentation. This study was funded by FONACIT, Caracas, Venezuela,
   grant G-2005-000-384. and by the CDCH-T, Los Andes University, grant
   M-794-04-07-B. We are grateful to Francoise Salager-Meyer for her
   editorial assistance.
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NR 40
TC 30
Z9 35
U1 0
U2 8
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0920-9964
EI 1573-2509
J9 SCHIZOPHR RES
JI Schizophr. Res.
PD MAR
PY 2011
VL 126
IS 1-3
BP 93
EP 102
DI 10.1016/j.schres.2010.10.014
PG 10
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 743NS
UT WOS:000289025700014
PM 21071179
DA 2025-06-11
ER

PT J
AU Yang, KF
   Shen, XH
   Cai, W
AF Yang, Ke-Feng
   Shen, Xiu-Hua
   Cai, Wei
TI Prenatal and early postnatal exposure to high-saturated-fat diet
   represses Wnt signaling and myogenic genes in offspring rats
SO EXPERIMENTAL BIOLOGY AND MEDICINE
LA English
DT Article
DE perinatal stress; thrifty phenotype hypothesis; myogenesis; high-fat
   diet; Wnt signaling; metabolic syndrome
ID THRIFTY PHENOTYPE HYPOTHESIS; ADULT SKELETAL-MUSCLE; JUNK FOOD DIET;
   DIABETES-MELLITUS; BETA-CATENIN; OBESITY; MYOD; LACTATION; INSULIN;
   NUTRITION
AB The prenatal and early postnatal period is a key developmental window for nutrition status, and high-fat exposure in this period has been shown to be associated with type 2 diabetes, obesity and other features of metabolic disorders later in life. The present study was designed to investigate the underlying molecular mechanisms and role of relative genes involved in this process. We investigated the impact of prenatal and early postnatal exposure to a high-saturated-fat diet on the regulation of the Wnt signaling pathway and myogenic genes in skeletal muscle of rat offspring as well as the serum and muscle physiological outcomes. Timed-pregnant Sprague-Dawley rats were fed either a control (C, 16% kcal fat) or high-saturated-fat diet (HF, 45% kcal fat) throughout gestation and lactation. After weaning, female offspring were fed a control diet to generate two offspring groups: control diet-fed offspring of control diet-fed dams (C/C) and control diet-fed offspring of HF diet-fed dams (HF/C). The serum glucose of the HF/C offspring (5.58 +/- 0.26 mmol/L) was significantly higher than that of C/C offspring (4.97 +/- 0.28 mmol/L), and the Homeostasis Model Assessment-Insulin Resistance of HF/C offspring (2.00 +/- 0.11) was also significantly higher when compared with C/C (1.84 +/- 0.09). Furthermore, HF/C offspring presented excessive intramuscular fat accumulation (1.8-fold, P < 0.05) and decreased muscle glycogen (1.3-fold, P < 0.05), as well as impairment of muscle development at the age of 12 weeks. Meanwhile, we observed the repression of Wnt/beta-catenin signaling and myogenic genes in HF/C offspring. The present study indicates that prenatal and early postnatal exposure to a high-saturated-fat diet suppresses the development of skeletal muscle and myogenic genes via Wnt/beta-catenin signaling, and the inappropriate muscle development could potentially contribute to the predisposition of offspring to develop metabolic-syndrome-like phenotype in adulthood.
C1 [Yang, Ke-Feng; Shen, Xiu-Hua; Cai, Wei] Shanghai Jiao Tong Univ, Sch Med, Xin Hua Hosp, Clin Nutr Ctr, Shanghai 200092, Peoples R China.
   [Yang, Ke-Feng; Shen, Xiu-Hua; Cai, Wei] Shanghai Jiao Tong Univ, Sch Med, Dept Nutr, Shanghai 200025, Peoples R China.
   [Yang, Ke-Feng; Cai, Wei] Shanghai Inst Pediat Res, Shanghai 200092, Peoples R China.
   [Yang, Ke-Feng; Cai, Wei] Shanghai Key Lab Pediat Gastroenterol & Nutr, Shanghai 200092, Peoples R China.
C3 Shanghai Jiao Tong University; Shanghai Jiao Tong University
RP Cai, W (corresponding author), Shanghai Jiao Tong Univ, Sch Med, Xin Hua Hosp, Clin Nutr Ctr, 1665 Kongjiang Rd, Shanghai 200092, Peoples R China.
EM caiw204@yahoo.com.cn
RI cai, wei/JPY-3260-2023; 杨, 科峰/ISB-7962-2023; shen, Rachel/LCL-2708-2024
FU National Natural Science Foundation of China [30772270, 30972427];
   Program for Innovative Research Team of Shanghai Municipal Education
   Commission
FX The present study was supported by the National Natural Science
   Foundation of China (No. 30772270, 30972427) and Program for Innovative
   Research Team of Shanghai Municipal Education Commission.
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NR 42
TC 6
Z9 7
U1 1
U2 18
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1535-3702
EI 1535-3699
J9 EXP BIOL MED
JI Exp. Biol. Med.
PD AUG
PY 2012
VL 237
IS 8
BP 912
EP 918
DI 10.1258/ebm.2012.011395
PG 7
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 013KD
UT WOS:000309303400005
PM 22875341
DA 2025-06-11
ER

PT J
AU Sakr, HF
   Abbas, AM
   Khalil, K
   Shata, AM
AF Sakr, H. F.
   Abbas, A. M.
   Khalil, K.
   Shata, A. M.
TI MODULATORY EFFECT OF CONCOMITANT ADMINISTRATION OF SITAGLIPTIN AND
   VITAMIN E ON INFLAMMATORY BIOMARKERS IN RATS FED WITH HIGH FAT DIET:
   ROLE OF ADIPONECTIN
SO JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
LA English
DT Article
DE adiponectin; sitagliptin; vitamin E; hypercholesterolemia; senescence
   marker protein 30; oxidative stress; type 2 diabetes mellitus;
   non-alcoholic fatty liver disease; C-reactive protein
ID OXIDATIVE STRESS; HIGH CHOLESTEROL; NONALCOHOLIC STEATOHEPATITIS;
   DIABETIC-NEPHROPATHY; CARDIAC DYSFUNCTIONS; INSULIN-RESISTANCE;
   METABOLIC SYNDROME; OVERWEIGHT RATS; LIVER-DISEASE; FRUCTOSE DIET
AB Sitagliptin (SIT) is an antidiabetic used worldwide to ameliorate the hyperglycemia and insulin insensitivity induced dysmetabolism. In this study, we investigated the effect of sitagliptin and vitamin E on metabolic dysfunction in high-fat diet (HFD) fed rats. Sixty-four male rats were allocated into 8 groups (n = 8) as follow; control, control + vitamin E, control + sitagliptin, control + sitagliptin + vitamin E, HFD, HFD + vitamin E, HFD + sitagliptin and HFD + sitagliptin + vitamin E. Control groups were fed with chow diet for 15 weeks, while HFD groups were fed with HFD for the same duration. Vitamin E and sitagliptin were administered in the last 4 weeks of the study. At the end of the 15th week, body weight, liver weight/body weight ratio, weight gain, glucose, lipid profile, liver enzymes, adiponectin and proinflammatory cytokines as interleukin 6 (IL-6), high sensitive C reactive protein (hs-CRP) and tumour necrosis factor-alpha (TNF-alpha) were measured. Additionally, gene expressions of senescence marker protein 30 (SMP30), Bcl-2, and Bax were measured. Total antioxidant capacity (TAC) and thiobaribituric acid reactive substances (TBARS) were assayed. HFD increased TBARS, IL-6, hs-CRP and TNF-alpha significantly and decreased TAC and adiponectin. Sitagliptin produced a comparable result through increasing adiponectin, sitagliptin alone or in combination with vitamin E increased the TAC, and gene expression of SMP30 and Bcl-2 and decreased TBARS with downregulation of the overexpressed Bax. Vitamin E, as a natural antioxidant, ameliorates the oxidative stress with insignificant change in lipid profile and inflammatory cytokine levels. Concomitant sitagliptin and vitamin E reduced the hepatic dysfunction induced by HFD.
C1 [Sakr, H. F.] Sultan Qaboos Univ, Coll Med & Hlth Sci, Dept Physiol, Muscat, Oman.
   [Abbas, A. M.] King Khalid Univ, Coll Med, Dept Physiol, Abha, Saudi Arabia.
   [Khalil, K.] Majmaah Univ, Coll Med, Dept Physiol, Al Majmaah, Saudi Arabia.
   [Sakr, H. F.; Abbas, A. M.; Khalil, K.] Mansoura Univ, Fac Med, Med Physiol Dept, Mansoura, Egypt.
   [Shata, A. M.] Mansoura Univ, Fac Med, Clin Pharmacol Dept, Mansoura, Egypt.
C3 Sultan Qaboos University; King Khalid University; Majmaah University;
   Egyptian Knowledge Bank (EKB); Mansoura University; Egyptian Knowledge
   Bank (EKB); Mansoura University
RP Sakr, HF (corresponding author), Manoura Univ, Dept Physiol, Fac Med, POB 35516, Mansoura, Egypt.
EM hsakr@squ.edu.om
RI khalil, khaled/M-6138-2018; Sakr, Hussein/O-4888-2018
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NR 69
TC 9
Z9 10
U1 0
U2 2
PU POLISH PHYSIOLOGICAL SOC
PI GRZEGORZECKA
PA JAGIELLONIAN UNIV SCHOOL MED, INST PHYSIOLOGY, 31-531 KRAKOW, 16
   GRZEGORZECKA, POLAND
SN 0867-5910
J9 J PHYSIOL PHARMACOL
JI J. Physiol. Pharmacol.
PD DEC
PY 2019
VL 70
IS 6
BP 955
EP 967
DI 10.26402/jpp.2019.6.13
PG 13
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA LD2FH
UT WOS:000525846300013
PM 32203939
DA 2025-06-11
ER

PT J
AU Ahn, HY
   Kim, M
   Seo, CR
   Yoo, HJ
   Lee, SH
   Lee, JH
AF Ahn, Hyeon Yeong
   Kim, Minjoo
   Seo, Cho Rong
   Yoo, Hye Jin
   Lee, Sang-Hyun
   Lee, Jong Ho
TI The effects of Jerusalem artichoke and fermented soybean powder mixture
   supplementation on blood glucose and oxidative stress in subjects with
   prediabetes or newly diagnosed type 2 diabetes
SO NUTRITION & DIABETES
LA English
DT Article
ID IMPAIRED FASTING GLUCOSE; LONG-TERM CONSUMPTION; LIPID-PEROXIDATION;
   INSULIN-RESISTANCE; HELIANTHUS-TUBEROSUS; METABOLIC SYNDROME; INULIN;
   MELLITUS; DISEASE; OLIGOFRUCTOSE
AB Background/Objectives: The objective of this study was to evaluate the effect of supplementation with a Jerusalem artichoke and fermented soybean powder mixture on blood glucose and oxidative stress levels.
   Subjects/Methods: This randomized, double-blinded, placebo-controlled study was conducted on 60 subjects with impaired fasting glucose (IFG), impaired glucose tolerance (IGT), or newly diagnosed type 2 diabetes. The subjects were randomly assigned to either a group that ingested 40 g of a Jerusalem artichoke and fermented soybean powder mixture (19.45 g each) daily or a group that received a placebo for 12 weeks. Paired t-test and independent t-test were performed for comparisons within groups and between groups, respectively.
   Results: Supplementation with the Jerusalem artichoke and fermented soybean powder mixture reduced the levels of fasting glucose (p < 0.001) and FFAs (p = 0.034), glucose at 60 min (p = 0.004), glucose (p = 0.006) areas under the response curve (AUC), homeostasis model assessment-insulin resistance (p = 0.018), and the urinary 8-epi- prostaglandin F-2 alpha (8-epi-PGF(2 alpha)) level (p = 0.028). The changes (Delta) in urinary 8-epi-PGF(2 alpha), glucose at 60 min, 120 min, and AUC, FFAs at 0 min and AUC were significantly different between the two groups. In addition, Delta glucose at 120 min (r = 0.472, p = 0.027) and the Delta glucose AUC (r= 0.572, p = 0.005) were positively correlated with Delta plasma malondialdehyde in the test group.
   Conclusions: The consumption of a Jerusalem artichoke and fermented soybean powder mixture for 12 weeks was effective for reducing postprandial glucose and oxidative stress level, particularly 8-epi-PGF(2 alpha), in subjects with IFG, IGT, or newly diagnosed type 2 diabetes.
C1 [Ahn, Hyeon Yeong; Kim, Minjoo; Lee, Jong Ho] Yonsei Univ, Res Ctr Silver Sci, Inst Symbiot Life TECH, Seoul, South Korea.
   [Seo, Cho Rong] Yonsei Univ, Dept Sci Aging, Grad Sch, Seoul, South Korea.
   [Yoo, Hye Jin; Lee, Jong Ho] Yonsei Univ, Coll Human Ecol, Dept Food & Nutr, Brain Korea PLUS Project 21, Seoul, South Korea.
   [Lee, Sang-Hyun] Natl Hlth Insurance Corp, Dept Family Practice, Ilsan Hosp, Goyang, South Korea.
   [Lee, Jong Ho] Yonsei Univ, Coll Human Ecol, Dept Food & Nutr, Natl Leading Res Lab Clin Nutrigenet Nutrigen, Seoul, South Korea.
   [Lee, Jong Ho] Yonsei Univ, Cardiovasc Res Inst, Coll Med, Seoul, South Korea.
C3 Yonsei University; Yonsei University; Yonsei University; NHIS Ilsan
   Hospital; Yonsei University; Yonsei University; Yonsei University Health
   System
RP Lee, JH (corresponding author), Yonsei Univ, Res Ctr Silver Sci, Inst Symbiot Life TECH, Seoul, South Korea.; Lee, JH (corresponding author), Yonsei Univ, Coll Human Ecol, Dept Food & Nutr, Brain Korea PLUS Project 21, Seoul, South Korea.; Lee, JH (corresponding author), Yonsei Univ, Coll Human Ecol, Dept Food & Nutr, Natl Leading Res Lab Clin Nutrigenet Nutrigen, Seoul, South Korea.; Lee, JH (corresponding author), Yonsei Univ, Cardiovasc Res Inst, Coll Med, Seoul, South Korea.
EM jhleeb@yonsei.ac.kr
RI Kim, Minjoo/AEN-5516-2022; Choi, Kyung/C-4195-2018; Kang,
   Hyun-Seung/J-5365-2012
FU "Food Functionality Evaluation Program" under the Ministry of Food,
   Agriculture, Forestry and Fisheries; Bio-Synergy Research Project of the
   Ministry of Science, ICT and Future Planning through the National
   Research Foundation, Republic of Korea [NRF-2012M3A9C4048762]
FX We thank all the volunteers who participated in this study for their
   cooperation. This work was supported in part by the "Food Functionality
   Evaluation Program" under the Ministry of Food, Agriculture, Forestry
   and Fisheries and by the Bio-Synergy Research Project
   (NRF-2012M3A9C4048762) of the Ministry of Science, ICT and Future
   Planning through the National Research Foundation, Republic of Korea.
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NR 56
TC 31
Z9 31
U1 0
U2 29
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 2044-4052
J9 NUTR DIABETES
JI Nutr. Diabetes
PD JUL 19
PY 2018
VL 8
AR 42
DI 10.1038/s41387-018-0052-y
PG 13
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA GN9IZ
UT WOS:000439511200001
PM 30026514
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Prescott, SL
   Logan, AC
AF Prescott, Susan L.
   Logan, Alan C.
TI Each meal matters in the exposome: Biological and community
   considerations in fast-food-socioeconomic associations
SO ECONOMICS & HUMAN BIOLOGY
LA English
DT Article
DE Food and nutrition; Obesity; Heart disease; Socioeconomic gradient;
   Health inequities; Social justice; Ecology; Microbiome; Disease
   prevention; Health policy; Equity; Holism; Health translation;
   Non-communicable diseases (NCDs); Lifestyle medicine
ID HIGH-FAT MEAL; 3RD NATIONAL-HEALTH; NEIGHBORHOOD POVERTY; METABOLIC
   SYNDROME; INFLAMMATORY MARKERS; MEDITERRANEAN MEAL; ALLOSTATIC LOAD; DNA
   METHYLATION; GUT MICROBIOME; UNITED-STATES
AB Advances in omics and microbiome technology have transformed the ways in which the biological consequences of life in the 'ecological theatre' can be visualized. Exposome science examines the total accumulated environmental exposures (both detrimental and beneficial) as a means to understand the response of the 'total organism to the total environment' over time. The repetitive stimulation of compensatory physiological responses (immune, cardiovascular, neuroendocrine) in response to stress including sources of stress highly relevant to socioeconomic disadvantage - may lead to metabolic dysregulation and cellular damage, ultimately influencing behavior and disease. The collective toll of physiological wear and tear, known as allostatic load, is not paid equally throughout developed societies. It is paid in excess by the disadvantaged. In the context of fast-food, human and experimental research demonstrates that the biological response to a single fast-food-style meal-especially as mediated by the microbiome-is a product of the person's total lived experience, including the ability to buffer the fast-food meal-induced promotion of inflammation and oxidative stress. Emerging research indicates that each meal and its nutritional context matters. As we discuss, equal weekly visits to major fast-food outlets by the affluent and deprived do not translate into biological equivalency. Hence, debate concerning reducing fast-food outlets through policy-especially in disadvantaged neighborhoods where they are prevalent- requires a biological context. The fast-food establishment and fast-food meal- as they represent matters of food justice and press upon non-communicable disease risk-are far more than physical structures and collections of carbohydrate, fat, sugar and sodium. (C) 2017 The Authors. Published by Elsevier B.V.
C1 [Prescott, Susan L.] Univ Western Australia, Princess Margaret Hosp, Sch Med, POB D184, Perth, WA 6001, Australia.
   [Prescott, Susan L.; Logan, Alan C.] WUN, Res Grp, Int Inflammat In FLAME Network, 6010 Pk Ave,Suite 4081, West New York, NJ 07093 USA.
C3 Princess Margaret Hospital for Children; University of Western Australia
RP Prescott, SL (corresponding author), Univ Western Australia, Princess Margaret Hosp, Sch Med, POB D184, Perth, WA 6001, Australia.
EM susan.prescott@uwa.edu.au
RI Prescott, Susan/H-5665-2014
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NR 119
TC 30
Z9 30
U1 0
U2 21
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1570-677X
EI 1873-6130
J9 ECON HUM BIOL
JI Econ. Hum. Biol.
PD NOV
PY 2017
VL 27
BP 328
EP 335
DI 10.1016/j.ehb.2017.09.004
PN B
PG 8
WC Economics; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Business & Economics; Public, Environmental & Occupational Health
GA FQ2WO
UT WOS:000418218900004
PM 29107462
OA hybrid
DA 2025-06-11
ER

PT J
AU Allison, BJ
   Kaandorp, JJ
   Kane, AD
   Camm, EJ
   Lusby, C
   Cross, CM
   Nevin-Dolan, R
   Thakor, AS
   Derks, JB
   Tarry-Adkins, JL
   Ozanne, SE
   Giussani, DA
AF Allison, Beth J.
   Kaandorp, Joepe J.
   Kane, Andrew D.
   Camm, Emily J.
   Lusby, Ciara
   Cross, Christine M.
   Nevin-Dolan, Rhianon
   Thakor, Avnesh S.
   Derks, Jan B.
   Tarry-Adkins, Jane L.
   Ozanne, Susan E.
   Giussani, Dino A.
TI Divergence of mechanistic pathways mediating cardiovascular aging and
   developmental programming of cardiovascular disease
SO FASEB JOURNAL
LA English
DT Article
DE cell senescence; fetal hypoxia; oxidative stress; allopurinol; xanthine
   oxidase
ID POOR MATERNAL NUTRITION; CATCH-UP GROWTH; OXIDATIVE STRESS;
   XANTHINE-OXIDASE; ENDOTHELIAL FUNCTION; METABOLIC SYNDROME;
   HEART-DISEASE; BIRTH-WEIGHT; DNA-DAMAGE; RAT MODEL
AB Aging and developmental programming are both associated with oxidative stress and endothelial dysfunction, suggesting common mechanistic origins. However, their interrelationship has been little explored. In a rodent model of programmed cardiovascular dysfunction we determined endothelial function and vascular telomere length in young (4 mo) and aged (15 mo) adult offspring of normoxic or hypoxic pregnancy with or without maternal antioxidant treatment. We show loss of endothelial function [maximal arterial relaxation to acetylcholine (71 +/- 3 vs. 55 +/- 3%) and increased vascular short telomere abundance (4.2-1.3 kb) 43.0 +/- 1.5 vs. 55.1 +/- 3.8%) in aged vs. young offspring of normoxic pregnancy (P < 0.05). Hypoxic pregnancy in young off-spring accelerated endothelial dysfunction (maximal arterial relaxation to acetylcholine: 42 +/- 1%, P < 0.05) but this was dissociated from increased vascular short telomere length abundance. Maternal allopurinol rescued maximal arterial relaxation to acetylcholine in aged offspring of normoxic or hypoxic pregnancy but not in young offspring of hypoxic pregnancy. Aged offspring of hypoxic allopurinol pregnancy compared with aged offspring of untreated hypoxic pregnancy had lower levels of short telomeres (vascular short telomere length abundance 35.1 +/- 2.5 vs. 48.2 +/- 2.6%) and of plasma proinflammatory chemokine (24.6 +/- 2.8 vs. 36.8 +/- 5.5 pg/ml, P < 0.05). These data provide evidence for divergence of mechanistic pathways mediating cardiovascular aging and developmental programming of cardiovascular disease, and aging being decelerated by antioxidants even prior to birth.-Allison, B.J., Kaandorp, J.J., Kane, A.D., Camm, E.J., Lusby, C., Cross, C.M., Nevin-Dolan, R., Thakor, A.S., Derks, J.B., Tarry-Adkins, J.L., Ozanne, S.E., Giussani, D.A. Divergence of mechanistic pathways mediating cardiovascular aging and developmental programming of cardiovascular disease. www.fasebj.org
C1 [Allison, Beth J.; Kane, Andrew D.; Camm, Emily J.; Lusby, Ciara; Cross, Christine M.; Nevin-Dolan, Rhianon; Thakor, Avnesh S.; Giussani, Dino A.] Univ Cambridge, Dept Physiol Dev & Neurosci, Downing St, Cambridge CB2 3EG, England.
   [Kaandorp, Joepe J.; Derks, Jan B.] Univ Med Ctr, Perinatol, Utrecht, Netherlands.
   [Tarry-Adkins, Jane L.; Ozanne, Susan E.] Wellcome Trust MRC Inst Metab Sci, Addenbrookes Hosp, Metab Res Labs, Cambridge, England.
   [Tarry-Adkins, Jane L.; Ozanne, Susan E.] Wellcome Trust MRC Inst Metab Sci, Addenbrookes Hosp, Med Reseach Council MRC Metab Dis Unit, Cambridge, England.
C3 University of Cambridge; Utrecht University; Utrecht University Medical
   Center; University of Cambridge; Cambridge University Hospitals NHS
   Foundation Trust; Addenbrooke's Hospital; Cambridge University Hospitals
   NHS Foundation Trust; Addenbrooke's Hospital; University of Cambridge
RP Giussani, DA (corresponding author), Univ Cambridge, Dept Physiol Dev & Neurosci, Downing St, Cambridge CB2 3EG, England.
EM dag26@camac.uk
RI ; Allison, Beth/J-9441-2015; Kane, Andrew/C-5876-2013
OI Ozanne, Susan/0000-0001-8753-5144; Allison, Beth/0000-0002-1060-513X;
   Kane, Andrew/0000-0001-9488-4086
FU Royal Society; MRC Metabolic Diseases Unit, Addenbrookes Hospital
   [MRC_MC_UU_12012/4]; British Heart Foundation; Wellcome Trust; Perinatal
   Centre Wilhelmina Children's Hospital Utrecht; Royal Dutch Academy of
   Sciences (Ter Meulen Fonds); Dutch Institute for Scientific Research;
   Dutch Society of Obstetrics and Gynecology; BBSRC [BB/E002668/1] Funding
   Source: UKRI; MRC [MC_UU_12012/4] Funding Source: UKRI
FX D.A.G. is Professor of Cardiovascular Physiology and Medicine at the
   Department of Physiology Development and Neuroscience at the University
   of Cambridge, Professorial Fellow and Director of Studies in Medicine at
   Gonville and Caius College, a Lister Institute Fellow, and a Royal
   Society Wolfson Research Merit Award Holder. S.E.O. is supported by the
   MRC Metabolic Diseases Unit, Addenbrookes Hospital (MRC_MC_UU_12012/4).
   The work was supported by The British Heart Foundation, The Wellcome
   Trust, The Perinatal Centre Wilhelmina Children's Hospital Utrecht, The
   Royal Dutch Academy of Sciences (Ter Meulen Fonds), The Dutch Institute
   for Scientific Research and The Dutch Society of Obstetrics and
   Gynecology. The authors declare no conflicts of interest.
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NR 69
TC 50
Z9 54
U1 0
U2 14
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
EI 1530-6860
J9 FASEB J
JI Faseb J.
PD MAY
PY 2016
VL 30
IS 5
BP 1968
EP 1975
DI 10.1096/fj.201500057
PG 8
WC Biochemistry & Molecular Biology; Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA DK4HW
UT WOS:000374879400024
PM 26932929
OA Green Published, Green Accepted, hybrid
DA 2025-06-11
ER

PT J
AU Hermsdorff, HHM
   Barbosa, KBF
   Volp, ACP
   Puchau, B
   Bressan, J
   Zulet, MA
   Martínez, JA
AF Hermsdorff, Helen Hermana M.
   Barbosa, Kiriaque B. F.
   Volp, Ana Carolina P.
   Puchau, Blanca
   Bressan, Josefina
   Angeles Zulet, M.
   Alfredo Martinez, J.
TI Gender-specific relationships between plasma oxidized low-density
   lipoprotein cholesterol, total antioxidant capacity, and central
   adiposity indicators
SO EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
LA English
DT Article
DE Antioxidants; body fat distribution; glutathione peroxidase; oxidized
   LDL; sex difference; waist-to-hip ratio
ID OXIDATIVE STRESS BIOMARKERS; HORMONE REPLACEMENT THERAPY; HEALTHY-YOUNG
   ADULTS; POSTMENOPAUSAL WOMEN; METABOLIC SYNDROME; BODY-FAT;
   CARDIOVASCULAR RISK; SEX-DIFFERENCES; LIPID PROFILE; DISEASE
AB Background: Oxidative stress has a pivotal role in the onset of obesity-related chronic diseases. This study assessed potential gender differences in the associations of adiposity (total vs. central) with oxidative stress markers in healthy young adults.
   Methods: This cross-sectional study enrolled 272 subjects (97 males, 175 females; 22 +/- 3 years, body mass index 22.0 +/- 2.8 kg/m(2)). Body composition, cardiometabolic and lifestyle features, oxidized low-density lipoprotein cholesterol (ox-LDL) concentrations, plasma total antioxidant capacity (TAC), and glutathione peroxidase (GPx) activity in erythrocytes were determined by validated procedures.
   Results: Compared to women, men had statistically higher concentrations of ox-LDL (61.7 vs. 53.5 U/l, p 0.022). In analyses with the whole sample, those individuals included in the highest tertile of central adiposity indicators (waist circumference, WC, or waist-to-hip ratio, WHR) presented higher ox-LDL and lower TAC values (p < 0.01), while no statistical differences were found across tertiles of total body fat. WHR values were more strongly associated with ox-LDL and TAC concentrations, compared to other adiposity indicators, with higher slopes for women. Sex differences in ox-LDL concentrations were abolished (p > 0.05) after individual pairing of men and women for WC (53.8 vs. 61.6 U/l, p = 0.225) or WHR (56.1 vs. 56.3 U/l, p = 0.471). No differences were found in GPx values concerning gender or adiposity indicators.
   Conclusions: Plasma ox-LDL and TAC values were more strongly influenced by central adiposity indicators (WHR and WC) in women than in men, suggesting that the change of the gynoid to android pattern phenotype among young women could lead to a steeper unfavourable redox status compared to men.
C1 [Hermsdorff, Helen Hermana M.; Bressan, Josefina] Univ Fed Vicosa, Dept Nutr & Hlth, Vicosa, MG, Brazil.
   [Barbosa, Kiriaque B. F.] Univ Fed Sergipe, Nutr Ctr, Aracaju, Brazil.
   [Volp, Ana Carolina P.] Univ Fed Ouro Preto, Dept Clin & Social Nutr, Ouro Preto, Brazil.
   [Puchau, Blanca; Angeles Zulet, M.; Alfredo Martinez, J.] Univ Navarra, Dept Nutr Food Sci Physiol & Toxicol, E-31080 Pamplona, Spain.
C3 Universidade Federal de Vicosa; Universidade Federal de Sergipe;
   Universidade Federal de Ouro Preto; University of Navarra
RP Martínez, JA (corresponding author), Univ Navarra, Dept Nutr Food Sci Physiol & Toxicol, C Irunlarrea 1, Navarra 31008, Spain.
EM jalfmtz@unav.es
RI Barbosa, Kiriaque/E-4269-2014; Bressan, Josefina/A-2598-2009; Zulet, M.
   Angeles/H-1317-2017; Martinez Hernandez, J Alfredo/K-8709-2014;
   Hermsdorff, Helen Hermana Miranda/H-4525-2015
OI Zulet, M. Angeles/0000-0002-3926-0892; Bressan,
   Josefina/0000-0002-4993-9436; Martinez Hernandez, J
   Alfredo/0000-0001-5218-6941; Hermsdorff, Helen Hermana
   Miranda/0000-0002-4441-6572
FU Health Department of the Government of Navarra [22/2007]; Linea Especial
   about Nutrition, Obesity and Health [UNAV LE/97]; CIBERobn; RETICS
   (isaiii, Spain); Foundation for Research Support of the State of Minas
   Gerais [FAPEMIG- CDS 303/06]; Capes Foundation (Brazil) [CAPES/MECD-DGU
   109/06]; Ministry of Education of Spain [PHB-2005-0119-PC]
FX This work was supported by Health Department of the Government of
   Navarra (22/2007), Linea Especial about Nutrition, Obesity and Health
   (UNAV LE/97), CIBERobn, RETICS (isaiii, Spain), and Foundation for
   Research Support of the State of Minas Gerais (FAPEMIG- CDS 303/06). The
   Capes Foundation (Brazil, CAPES/MECD-DGU 109/06) as well as to Ministry
   of Education of Spain (PHB-2005-0119-PC) funded the Interuniversity
   Cooperation.
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NR 38
TC 24
Z9 27
U1 0
U2 7
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 2047-4873
EI 2047-4881
J9 EUR J PREV CARDIOL
JI Eur. J. Prev. Cardiol.
PD JUL
PY 2014
VL 21
IS 7
BP 884
EP 891
DI 10.1177/2047487312472420
PG 8
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA AJ3MW
UT WOS:000337571700011
PM 23253745
OA Bronze
DA 2025-06-11
ER

PT J
AU Atamer, A
   Övünç, AOK
   Yesil, A
   Atamer, Y
AF Atamer, Aytac
   Ovunc, Ayse Oya Kurdas
   Yesil, Atakan
   Atamer, Yildiz
TI Evaluation of leptin and insulin resistance in patients with
   cholelithiasis
SO INDIAN JOURNAL OF BIOCHEMISTRY & BIOPHYSICS
LA English
DT Article
DE Leptin; Insulin Resistance; Lipoproteins; Cholelithiasis
ID HOMEOSTASIS MODEL ASSESSMENT; GALLBLADDER-DISEASE; OXIDATIVE STRESS;
   REACTIVE OXYGEN; ADIPOSE-TISSUE; GLUCOSE; MECHANISMS; GENES;
   PARAOXONASE-1; LIPOPROTEINS
AB The association between insulin resistance, lipoproteins and leptin was evaluated in cholelithiasis. The study group included 55 women (68.8%) and 25 men (31.3%) with a mean age and SD of 50.56 +/- 14.28 yrs. The control group included 25 women (62.5%) and 15 men (37.5%) with a mean age of 50.93 +/- 11.73 yrs. Serum leptin levels were measured by the enzyme immunoassay method. HOMA-LR was determined by using fasting glucose and insulin levels. Insulin, total cholesterol (TC), LDL-C, HOMA-IR (p<0.01) and leptin (p<0.001) were significantly higher in the cholelithiasis group, compared to the controls. In patients with a HOMA-IR >2.2, age, body mass index (BMI), glucose, insulin, triglycerides (TG), TC and leptin levels were higher than in patients with a HOMA-IR <2.2. In patients with glucose levels >100 mg/dl, mean BMI, HOMA-IR, insulin, TG, TC and leptin levels were significantly higher than in patients with glucose levels <100 mg/dl. In patients with TG levels >150 mg/dl, mean age, BMI, glucose, insulin, TC, leptin and HOMA-IR were significantly higher than in patients with TG levels <150 mg/dl. In patients with BMI >25 kg/m(2), mean age, glucose, insulin, TG, TC, leptin, HOMA-IR were significantly higher than in patients with BMI <25. In cholelithiasis group, there was a positive correlation between leptin and age, BMI, glucose, insulin, TG, TC, LDL-C or HOMA-IR. In conclusion, we found a positive association between increased leptin levels and abnormal lipoprotein metabolism in cholelithiasis. Cholelithiasis subjects with insulin resistance showed higher cardiometabolic risk factors than those without it.
C1 [Atamer, Aytac; Ovunc, Ayse Oya Kurdas; Yesil, Atakan] Haydarpasa Numune Training & Res Hosp, Minist Hlth, Dept Internal Med, Div Gastroenterol, Istanbul, Turkey.
   [Atamer, Yildiz] Yalova Univ, Termal Profess Sch, Yalova, Turkey.
C3 Istanbul Haydarpasa Numune Training & Research Hospital; Istanbul
   Bagcilar Training & Research Hospital; Istanbul Haydarpasa Sultan
   Abdulhamid Training & Research Hospital; Ministry of Health - Turkey;
   Yalova University
RP Atamer, A (corresponding author), Haydarpasa Numune Training & Res Hosp, Minist Hlth, Dept Internal Med, Div Gastroenterol, Istanbul, Turkey.
EM aytacatamer1@gmail.com
RI yesil, Atakan/GRF-1640-2022
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NR 54
TC 7
Z9 7
U1 0
U2 3
PU NATL INST SCIENCE COMMUNICATION-NISCAIR
PI NEW DELHI
PA DR K S KRISHNAN MARG, PUSA CAMPUS, NEW DELHI 110 012, INDIA
SN 0301-1208
EI 0975-0959
J9 INDIAN J BIOCHEM BIO
JI Indian J. Biochem. Biophys.
PD AUG
PY 2013
VL 50
IS 4
BP 266
EP 272
PG 7
WC Biochemistry & Molecular Biology; Biophysics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics
GA 226TL
UT WOS:000325058800003
PM 24772944
DA 2025-06-11
ER

PT J
AU Thierry, M
   Pasquis, B
   Buteau, B
   Fourgeux, C
   Dembele, D
   Leclere, L
   Gambert-Nicot, S
   Acar, N
   Bron, AM
   Creuzot-Garcher, CP
   Bretillon, L
AF Thierry, Magalie
   Pasquis, Bruno
   Buteau, Benedicte
   Fourgeux, Cynthia
   Dembele, Doulaye
   Leclere, Laurent
   Gambert-Nicot, Segolene
   Acar, Niyazi
   Bron, Alain M.
   Creuzot-Garcher, Catherine P.
   Bretillon, Lionel
TI Early adaptive response of the retina to a pro-diabetogenic diet:
   Impairment of cone response and gene expression changes in high-fructose
   fed rats
SO EXPERIMENTAL EYE RESEARCH
LA English
DT Article
DE Fructose; Retina; Diet; Gene expression; Electroretinography
ID LEBER CONGENITAL AMAUROSIS; ALPHA-B-CRYSTALLIN; INSULIN-RESISTANCE;
   MOUSE MODEL; DIABETIC-RETINOPATHY; METABOLIC SYNDROME; MICE; ACTIVATION;
   DISEASE; LEADS
AB The lack of plasticity of neurons to respond to dietary changes, such as high fat and high fructose diets, by modulating gene and protein expression has been associated with functional and behavioral impairments that can have detrimental consequences. The inhibition of high fat-induced rewiring of hypothalamic neurons induced obesity. Feeding rodents with high fructose is a recognized and widely used model to trigger obesity and metabolic syndrome. However the adaptive response of the retina to short term feeding with high fructose is poorly documented. We therefore aimed to characterize both the functional and gene expression changes in the neurosensory retina of Brown Norway rats fed during 3 and 8 days with a 60%-rich fructose diet (n = 16 per diet and per time point). Glucose, insulin, leptin, triacylglycerols, total cholesterol, HDL-cholesterol, LDL-cholesterol and fructosamine were quantified in plasma (n = 8 in each group). Functionality of the inner retina was studied using scotopic single flash electroretinography (n = 8 in each group) and the individual response of rod and cone photoreceptors was determined using 8.02 Hz Flicker electroretinography (n = 8 in each group). Analysis of gene expression in the neurosensory retina was performed by Affymetrix genechips, and confirmed by RT-qPCR (n = 6 in each group). Elevated glycemia (+13%), insulinemia (+83%), and leptinemia (+172%) was observed after 8 days of fructose feeding. The cone photoreceptor response was altered at day 8 in high fructose fed rats (A = 0.5 log unit of light stimulus intensity). Affymetrix analysis of gene expression highlighted significant modulation of the pathimays of eIF2 signaling and endoplasmic reticulum stress, regulation of eIF4 and p70S6K signaling, as well as mTOR signaling and mitochondrial dysfunction. RT-qPCR analysis confirmed the down regulation of Crystallins, Npy, Nid1 and Optc genes after 3 days of fructose feeding, and up regulation of End2. Meanwhile, a trend towards an increased expression of alpha A- and alpha B-clystallin proteins was observed at day 8. Our results are consistent with early alterations of the functioning and gene expression in the retina in a pro diabetogenic environment. (C) 2015 Elsevier Ltd. All rights reserved.
C1 [Thierry, Magalie; Pasquis, Bruno; Buteau, Benedicte; Fourgeux, Cynthia; Leclere, Laurent; Gambert-Nicot, Segolene; Acar, Niyazi; Bron, Alain M.; Creuzot-Garcher, Catherine P.; Bretillon, Lionel] INRA, UMR1324, Ctr Sci Gout & Alimentat, Eye & Nutr Res Grp, F-21000 Dijon, France.
   [Thierry, Magalie; Pasquis, Bruno; Buteau, Benedicte; Fourgeux, Cynthia; Leclere, Laurent; Gambert-Nicot, Segolene; Acar, Niyazi; Bron, Alain M.; Creuzot-Garcher, Catherine P.; Bretillon, Lionel] CNRS, UMR6265, Ctr Sci Gout & Alimentat, F-21000 Dijon, France.
   [Thierry, Magalie; Pasquis, Bruno; Buteau, Benedicte; Fourgeux, Cynthia; Leclere, Laurent; Gambert-Nicot, Segolene; Acar, Niyazi; Bron, Alain M.; Creuzot-Garcher, Catherine P.; Bretillon, Lionel] Univ Bourgogne, Ctr Sci Gout & Alimentat, F-21000 Dijon, France.
   [Dembele, Doulaye] INSERM, UMR964, Inst Genet & Biol Mol & Cellulaire, F-67404 Illkirch Graffenstaden, France.
   [Dembele, Doulaye] CNRS, UMR7104, Inst Genet & Biol Mol & Cellulaire, F-67404 Illkirch Graffenstaden, France.
   [Dembele, Doulaye] Univ Strasbourg, Inst Genet & Biol Mol & Cellulaire, F-67404 Illkirch Graffenstaden, France.
   [Dembele, Doulaye] IGBMC, Microarray & Sequencing Platform, F-67404 Illkirch Graffenstaden, France.
   [Gambert-Nicot, Segolene] Univ Hosp, Dept Clin Chem, F-21000 Dijon, France.
   [Bron, Alain M.; Creuzot-Garcher, Catherine P.] Univ Hosp, Dept Ophthalmol, F-21000 Dijon, France.
C3 Institut Agro; AgroSup Dijon; Centre National de la Recherche
   Scientifique (CNRS); Universite Bourgogne Europe; INRAE; Institut Agro;
   AgroSup Dijon; Centre National de la Recherche Scientifique (CNRS);
   Universite Bourgogne Europe; CNRS - National Institute for Biology
   (INSB); Institut Agro; AgroSup Dijon; Centre National de la Recherche
   Scientifique (CNRS); Universite Bourgogne Europe; Universites de
   Strasbourg Etablissements Associes; Universite de Strasbourg; Institut
   National de la Sante et de la Recherche Medicale (Inserm); Universites
   de Strasbourg Etablissements Associes; Universite de Strasbourg;
   Institut National de la Sante et de la Recherche Medicale (Inserm);
   Centre National de la Recherche Scientifique (CNRS); CNRS - National
   Institute for Biology (INSB); Institut National de la Sante et de la
   Recherche Medicale (Inserm); Universites de Strasbourg Etablissements
   Associes; Universite de Strasbourg; Institut National de la Sante et de
   la Recherche Medicale (Inserm); Universite Bourgogne Europe; CHU Dijon
   Bourgogne; Universite Bourgogne Europe; CHU Dijon Bourgogne
RP Bretillon, L (corresponding author), Ctr INRA, Ctr Sci Gout & Alimentat, 17 Rue Sully,BP86510, F-21065 Dijon, France.
EM lionel.bretillon@dijon.inra.fr
RI Bron, Alain/AAP-8010-2020; Dembele, Doulaye/O-6513-2017
OI Bretillon, Lionel/0000-0002-6957-100X; Dembele,
   Doulaye/0000-0003-3879-6940
FU Laboratoires Horus Pharma (Saint Laurent du Var, France); Regional
   Council of Burgundy France (PARI Agrale 1); FEDER (European Funding for
   Regional Economic Development); INRA; CNRS; Universite de Bourgogne;
   French Government [ANR-11-LABX-0021-01-LipSTIC Labex]
FX This work was supported by grants from Laboratoires Horus Pharma (Saint
   Laurent du Var, France), the Regional Council of Burgundy France (PARI
   Agrale 1), the FEDER (European Funding for Regional Economic
   Development), INRA, CNRS, Universite de Bourgogne, and by a French
   Government grant managed by the French National Research Agency (ANR)
   under the "Investissements d'Avenir" program with reference
   ANR-11-LABX-0021-01-LipSTIC Labex. The funders had no role in study
   design, data collection and analysis, decision to publish, or
   preparation of the manuscript.
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NR 51
TC 13
Z9 14
U1 0
U2 6
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 0014-4835
EI 1096-0007
J9 EXP EYE RES
JI Exp. Eye Res.
PD JUN
PY 2015
VL 135
BP 37
EP 46
DI 10.1016/j.exer.2015.04.012
PG 10
WC Ophthalmology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Ophthalmology
GA CJ8RC
UT WOS:000355770200004
PM 25912194
DA 2025-06-11
ER

PT J
AU Martino, F
   Bassareo, PP
   Martino, E
   Romeo, F
   Calcaterra, G
   Filardi, PP
   Indolfi, C
   Nodari, S
   Montemurro, V
   Guccione, P
   Di Salvo, G
   Chessa, M
   Pedrinelli, R
   Mercuro, G
   Barilla, F
AF Martino, Francesco
   Bassareo, Pier Paolo
   Martino, Eliana
   Romeo, Francesco
   Calcaterra, Giuseppe
   Perrone Filardi, Pasquale
   Indolfi, Ciro
   Nodari, Savina
   Montemurro, Vincenzo
   Guccione, Paolo
   Di Salvo, Giovanni
   Chessa, Massimo
   Pedrinelli, Roberto
   Mercuro, Giuseppe
   Barilla, Francesco
TI Cardiovascular prevention in childhood: a consensus document of the
   Italian Society of Cardiology Working Group on Congenital Heart Disease
   and Cardiovascular Prevention in Paediatric Age
SO JOURNAL OF CARDIOVASCULAR MEDICINE
LA English
DT Review
DE atherosclerosis; cardiovascular disease; children; epigenetics;
   oxidative stress; prevention
ID INTIMA-MEDIA THICKNESS; DENSITY-LIPOPROTEIN CHOLESTEROL; TYPE-2
   DIABETES-MELLITUS; HIGH BLOOD-PRESSURE; BODY-MASS INDEX; FAMILIAL
   HYPERCHOLESTEROLEMIA; RISK-FACTORS; OXIDATIVE STRESS; MATERNAL
   HYPERCHOLESTEROLEMIA; METABOLIC-SYNDROME
AB Cardiovascular diseases (CVD) may be manifested from a very early age. Genetic and environmental (epigenetic) factors interact to affect development and give rise to an abnormal phenotypical expression of genetic information, although not eliciting changes in the nucleotide sequence of DNA. It has been scientifically proven that increased oxidative stress (OS) caused by disease (overweight, obesity, diabetes), nutritional imbalances, unhealthy lifestyles (smoking, alcohol, substance abuse) in the mother during pregnancy may induce placental dysfunction, intrauterine growth restriction, prematurity, low birth weight, postnatal adiposity rebound, metabolic alterations and consequent onset of traditional cardiovascular risk factors.OS represents the cornerstone in the onset of atherosclerosis and manifestation of CVD following an extended asymptomatic period. OS activates platelets and monocytes eliciting the release of pro-inflammatory, pro-atherogenic and pro-oxidising substances resulting in endothelial dysfunction, decrease in flow-mediated arterial dilatation and increase in carotid intima-media thickness. The prevention of CVD is defined as primordial (aimed at preventing risk factors development), primary (aimed at early identification and treatment of risk factors), secondary (aimed at reducing risk of future events in patients who have already manifested a cardiovascular event), and tertiary (aimed at limiting the complex outcome of disease). Atherosclerosis prevention should be implemented as early as possible. Appropriate screening should be carried out to identify children at high risk who are apparently healthy and implement measures including dietary and lifestyle changes, addition of nutritional supplements and, lastly, pharmacological treatment if risk profiles fail to normalise. Reinstating endothelial function during the reversible stage of atherosclerosis is crucial.
C1 [Martino, Francesco; Martino, Eliana] Univ Roma La Sapienza, Dept Internal Clin Anesthesiol & Cardiovasc Sci, Rome, Italy.
   [Bassareo, Pier Paolo] Univ Coll Dublin, Mater Misericordiae Univ Hosp, Sch Med, Dublin, Ireland.
   [Romeo, Francesco] UniCamillus Int Med Univ, Rome, Italy.
   [Calcaterra, Giuseppe] Univ Palermo, Post Grad Med Sch, Palermo, Italy.
   [Perrone Filardi, Pasquale] Univ Naples Federico II, Dept Adv Biomed Sci, Naples, Italy.
   [Indolfi, Ciro] Magna Graecia Univ Catanzaro, Res Ctr Cardiovasc Dis, Div Cardiol, Catanzaro, Italy.
   [Nodari, Savina] Univ Brescia, ASST Spedali Civili, Dept Med Surg Specialties Radiol Sci & Publ Hlth, Brescia, Italy.
   [Montemurro, Vincenzo] Scillesi Amer Hosp, Scilla, Reggio Calabria, Italy.
   [Guccione, Paolo] IRCCS Bambino Gesu Paediat Hosp, Dept Cardiol, Cardiac Surg, Cardiopulm Transplantat, Rome, Italy.
   [Di Salvo, Giovanni] Univ Padua, Dept Womens & Childrens Hlth, Div Paediat Cardiol, Padua, Italy.
   Univ Vita Salute San Raffaele, IRCCS Policlin San Donato, Pediat & Adult Congenital Heart Ctr, ACHD UNIT, Milan, Italy.
   Univ Pisa, Dept Surg Med & Mol Pathol & Crit Care Med, Pisa, Italy.
   Univ Cagliari, Cagliari, Italy.
   Tor Vergata Univ, Dept Syst Med, Rome, Italy.
   [Bassareo, Pier Paolo] Univ Coll Dublin, Sch Med, Mater Misericordiae Univ Hosp, Eccles St, Dublin D07 R2WY, Ireland.
C3 Sapienza University Rome; University College Dublin; Mater Misericordiae
   University Hospital; University of Palermo; University of Naples
   Federico II; Magna Graecia University of Catanzaro; University of
   Brescia; Hospital Spedali Civili Brescia; IRCCS Bambino Gesu; University
   of Padua; Vita-Salute San Raffaele University; IRCCS Policlinico San
   Donato; University of Pisa; University of Cagliari; University of Rome
   Tor Vergata; University College Dublin; Mater Misericordiae University
   Hospital
RP Bassareo, PP (corresponding author), Univ Coll Dublin, Sch Med, Mater Misericordiae Univ Hosp, Eccles St, Dublin D07 R2WY, Ireland.
EM piercard@inwind.it
RI Chessa, Massimo/ADD-4570-2022; Barillà, Francesco/Q-2665-2016; Nodari,
   Savina/K-4904-2018; Martino, Francesco/AAS-9718-2020; Perrone Filardi,
   Pasquale/AAC-7590-2022
OI Martino, Francesco/0000-0002-0368-1994
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NR 165
TC 6
Z9 6
U1 0
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1558-2027
EI 1558-2035
J9 J CARDIOVASC MED
JI J. Cardiovasc. Med.
PD AUG
PY 2023
VL 24
IS 8
BP 492
EP 505
DI 10.2459/JCM.0000000000001488
PG 14
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA L6ME4
UT WOS:001024375900003
PM 37409595
DA 2025-06-11
ER

PT J
AU Karamzad, N
   Maleki, V
   Carson-Chahhoud, K
   Azizi, S
   Sahebkar, A
   Gargari, BP
AF Karamzad, Nahid
   Maleki, Vahid
   Carson-Chahhoud, Kristin
   Azizi, Samaneh
   Sahebkar, Amirhossein
   Gargari, Bahram Pourghassem
TI A systematic review on the mechanisms of vitamin K effects on the
   complications of diabetes and pre-diabetes
SO BIOFACTORS
LA English
DT Review
DE antioxidant; diabetes; dyslipidemia; glycemic status; inflammation;
   menaquinone; MK-4; osteocalcin; oxidative stress; phyloquinone;
   pre-diabetes; vitamin K
ID GROWTH-FACTOR 21; INSULIN-RESISTANCE; OXIDATIVE STRESS; DIETARY
   PHYLLOQUINONE; METABOLIC SYNDROME; ENERGY-METABOLISM; MICROVASCULAR
   COMPLICATIONS; GLUCOSE-METABOLISM; GLYCEMIC CONTROL; PROTEIN-KINASE
AB Diabetes mellitus and pre-diabetes are prevalent endocrine disorders associated with substantial morbidity and premature mortality. Vitamin K is known to have several beneficial effects on complications of diabetes and pre-diabetes. However, systematic consolidation of evidence is required to quantify these effects in order to inform clinical practice and research. A systematic search in PubMed, Scopus, Embase, ProQuest, and Google Scholar databases was undertaken from database inception up to October 2018 to evaluate functional roles of different forms of vitamin K on diabetes and pre-diabetes. From 3,734 identified records, nine articles met the inclusion criteria and were evaluated. Vitamin K supplementation was found to be associated with significant reductions in blood glucose (six studies), increased fasting serum insulin (four studies), reduced hemoglobin A1c (three studies), reduced homeostatic model assessment-insulin resistance index (HOMA-IR) (two studies), and increased ss-cell function (two studies) in diabetic animal studies. Following 2-hour oral glucose tolerance test, vitamin K supplementation was observed to be effective in reducing blood glucose and insulin levels in the pre-diabetic population. However, no evidence of effect was observed for fasting blood sugar, insulin, HOMA-IR, and homeostatic model assessment-beta-cell function index (two studies). A statistically significant effect was also noted with vitamin K in improving dyslipidemia (three studies) as well as oxidative stress and inflammatory markers (five studies) in diabetic animals. In conclusion, clinical trials and animal studies confirm that vitamin K supplementation may improve both clinical features and complications of diabetes and pre-diabetes. However, quantification of clinical efficacy in the pre-diabetic population and among individuals with comorbidities requires further investigation.
C1 [Karamzad, Nahid; Maleki, Vahid; Azizi, Samaneh] Tabriz Univ Med Sci, Student Res Comm, Tabriz, Iran.
   [Karamzad, Nahid; Maleki, Vahid; Azizi, Samaneh; Gargari, Bahram Pourghassem] Tabriz Univ Med Sci, Fac Nutr & Food Sci, Dept Biochem & Diet Therapy, Tabriz, Iran.
   [Karamzad, Nahid; Gargari, Bahram Pourghassem] Tabriz Univ Med Sci, Fac Nutr & Food Sci, Nutr Res Ctr, Tabriz, Iran.
   [Carson-Chahhoud, Kristin] Univ South Australia, Sch Hlth Sci, Australian Ctr Precis Hlth, Adelaide, SA, Australia.
   [Carson-Chahhoud, Kristin] Univ Adelaide, Sch Med, Adelaide, SA, Australia.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Neurogen Inflammat Res Ctr, Mashhad, Razavi Khorasan, Iran.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Biotechnol Res Ctr, Mashhad, Razavi Khorasan, Iran.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Sch Pharm, Mashhad, Razavi Khorasan, Iran.
C3 Tabriz University of Medical Science; Tabriz University of Medical
   Science; Tabriz University of Medical Science; University of South
   Australia; University of Adelaide; Mashhad University of Medical
   Sciences; Mashhad University of Medical Sciences; Mashhad University of
   Medical Sciences
RP Gargari, BP (corresponding author), Tabriz Univ Med Sci, Fac Nutr & Food Sci, Dept Biochem & Diet Therapy, Tabriz, Iran.
EM bahrampg@yahoo.com
RI Azizi, Samaneh/AAB-7817-2021; Sahebkar, Amirhossein/B-5124-2018;
   Carson-Chahhoud, Kristin/I-1916-2018; Pourghassem Gargari,
   Bahram/D-3556-2017
OI Carson-Chahhoud, Kristin/0000-0001-9966-9289; Pourghassem Gargari,
   Bahram/0000-0001-7667-099X
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NR 128
TC 35
Z9 38
U1 0
U2 19
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0951-6433
EI 1872-8081
J9 BIOFACTORS
JI Biofactors
PD JAN
PY 2020
VL 46
IS 1
BP 21
EP 37
DI 10.1002/biof.1569
EA OCT 2019
PG 17
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA KF6CL
UT WOS:000491190900001
PM 31573736
DA 2025-06-11
ER

PT J
AU Leonetti, D
   Soleti, R
   Clere, N
   Vergori, L
   Jacques, C
   Duluc, L
   Dourguia, C
   Martínez, MC
   Andriantsitohaina, R
AF Leonetti, Daniela
   Soleti, Raffaella
   Clere, Nicolas
   Vergori, Luisa
   Jacques, Caroline
   Duluc, Lucie
   Dourguia, Catherine
   Martinez, Maria C.
   Andriantsitohaina, Ramaroson
TI Extract Enriched in Flavan-3-ols and Mainly Procyanidin Dimers Improves
   Metabolic Alterations in a Mouse Model of Obesity-Related Disorders
   Partially via Estrogen Receptor Alpha
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Article
DE estrogen receptor alpha; metabolic disorders; obesity; grape seed
   extract; vascular disorders
ID INDUCED DIABETIC-RATS; RED WINE POLYPHENOLS; DIET-INDUCED OBESITY;
   INSULIN-RESISTANCE; PLANT POLYPHENOLS; ADIPOSE-TISSUE; IN-VITRO;
   PROANTHOCYANIDINS; SUPPLEMENTATION; ANTHOCYANINS
AB Red wine polyphenol extracts improve cardiovascular and metabolic disorders linked to obesity. Their vascular protection is mediated by the activation of the alpha isoform of the estrogen receptor (ER alpha). In the present study, we explored the effects of a grape seed extract (GSE) enriched in the flavan-3-ols procyanidin dimers on obesity-related cardiovascular and metabolic disorders; with a particular interest in the role/contribution of ER alpha. Ovariectomized wild type or ER alpha knockout (KO) mice were fed with standard or western diet, supplemented or not with GSE, for 12 weeks. Their body weight was monitored throughout the study, and an echocardiography was performed at the end of the treatment. Blood and tissues were collected for biochemical and functional analysis, including nitric oxide and oxidative stress measurement. Vascular reactivity and liver mitochondrial complexes activity were also analyzed. In western diet-fed mice, GSE reduced adiposity, plasma triglycerides, and oxidative stress in the heart, liver, adipose and skeletal tissues; but did not improve the vascular dysfunction. In western diet-fed mice, ER alpha deletion prevented or reduced the beneficial effects of GSE on plasma triglycerides and visceral adiposity. ER alpha deletion also prevented/reduced the anti-oxidant effect of GSE in the liver, but did not affect its capacity to reduce oxidative stress in the heart and adipose tissue. In conclusion, dietary supplementation of GSE attenuated features of metabolic syndrome partially through ER alpha-dependent mechanisms. This report highlights the therapeutic potential of polyphenols, and especially extract enriched in procyanidin dimers, against the metabolic disorders associated with excessive energy intake.
C1 [Leonetti, Daniela; Soleti, Raffaella; Clere, Nicolas; Vergori, Luisa; Jacques, Caroline; Duluc, Lucie; Dourguia, Catherine; Martinez, Maria C.; Andriantsitohaina, Ramaroson] Univ Bretagne Loire, UNIV Angers, Fac Sante, INSERM UMR1063,Stress Oxydant & Pathol Metabol, Angers, France.
   [Martinez, Maria C.; Andriantsitohaina, Ramaroson] CHU Angers, Angers, France.
C3 Institut National de la Sante et de la Recherche Medicale (Inserm);
   Universite d'Angers; Universite d'Angers; Centre Hospitalier
   Universitaire d'Angers
RP Andriantsitohaina, R (corresponding author), Univ Bretagne Loire, UNIV Angers, Fac Sante, INSERM UMR1063,Stress Oxydant & Pathol Metabol, Angers, France.; Andriantsitohaina, R (corresponding author), CHU Angers, Angers, France.
EM ramaroson.andriantsitohaina@univ-angers.fr
RI SOLETI, RAFFAELLA/ABB-5455-2020; ANDRIANTSITOHAINA,
   Ramaroson/H-5286-2018; Clere, Nicolas/K-4414-2015; Martinez, Maria
   Carmen/LSJ-1622-2024
OI Martinez, M Carmen/0000-0003-3897-7397; andriantsitohaina,
   ramaroson/0000-0002-4770-3585; Clere, Nicolas/0000-0002-6008-597X;
   SOLETI, RAFFAELLA/0000-0002-0271-0490; Duluc, Lucie/0000-0002-5952-8008
FU grant of "OSEO" (bpiFrance "METAPOLYV")
FX This work was supported by grant of "OSEO" (bpiFrance "METAPOLYV").
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NR 55
TC 12
Z9 12
U1 0
U2 8
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD APR 24
PY 2018
VL 9
AR 406
DI 10.3389/fphar.2018.00406
PG 13
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA GD7UD
UT WOS:000430717600001
PM 29740325
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Tain, YL
   Lee, WC
   Wu, KLH
   Leu, S
   Chan, JYH
AF Tain, You-Lin
   Lee, Wei-Chia
   Wu, Kay L. H.
   Leu, Steve
   Chan, Julie Y. H.
TI Maternal High Fructose Intake Increases the Vulnerability to
   Post-Weaning High-Fat Diet-Induced Programmed Hypertension in Male
   Offspring
SO NUTRIENTS
LA English
DT Article
DE developmental origins of health and disease (DOHaD); high-fat; fructose;
   hypertension; nutrient sensing signal; oxidative stress; soluble epoxide
   hydrolase
ID DEVELOPMENTAL ORIGINS; RENAL TRANSCRIPTOME; NUTRITIONAL INSULTS;
   METABOLIC SYNDROME; BLOOD-PRESSURE; NITRIC-OXIDE; MECHANISMS; DISEASE;
   PREVENTS; OBESITY
AB Widespread consumption of high-fructose and high-fat diets relates to the global epidemic of hypertension. Hypertension may originate from early life by a combination of prenatal and postnatal nutritional insults. We examined whether maternal high-fructose diet increases vulnerability to post-weaning high-fructose or high-fat diets induced hypertension in adult offspring and determined the underlying mechanisms. Pregnant Sprague-Dawley rats received regular chow (ND) or chow supplemented with 60% fructose (HFR) during the entire pregnancy and lactation periods. Male offspring were onto either the regular chow, 60% fructose, or high-fat diet (HFA) from weaning to 12 weeks of age and assigned to four groups: ND/ND, HFR/ND, HFR/HFR, and HFR/HFA. Maternal high-fructose diet exacerbates post-weaning high-fat diet-induced programmed hypertension. Post-weaning high-fructose and high-fat diets similarly reduced Sirt4, Prkaa2, Prkag2, Ppara, Pparb, and Ppargc1a mRNA expression in offspring kidneys exposed to maternal high-fructose intake. Additionally, post-weaning high-fat diet significantly reduced renal mRNA levels of Ulk1, Atg5, and Nrf2 and induced greater oxidative stress than did high-fructose diet. Although maternal high-fructose intake increases soluble epoxide hydrolase (SEH) expression in the kidney, which was restored by post-weaning high-fructose and high-fat diets. Maternal high-fructose diet programs differential vulnerability to developing hypertension in male offspring in response to post-weaning high-fructose and high-fat diets. Our data implicated that specific therapy targeting on nutrient sensing signals, oxidative stress, and SEH may be a promising approach to prevent hypertension in children and mothers exposed to high-fructose and high-fat consumption.
C1 [Tain, You-Lin] Kaohsiung Chang Gung Mem Hosp, Dept Pediat, Kaohsiung 833, Taiwan.
   [Tain, You-Lin; Lee, Wei-Chia; Wu, Kay L. H.; Leu, Steve; Chan, Julie Y. H.] Chang Gung Univ, Coll Med, Kaohsiung 833, Taiwan.
   [Tain, You-Lin; Wu, Kay L. H.; Leu, Steve; Chan, Julie Y. H.] Kaohsiung Chang Gung Mem Hosp, Inst Translat Res Biomed, Kaohsiung 833, Taiwan.
   [Lee, Wei-Chia] Kaohsiung Chang Gung Mem Hosp, Dept Urol, Kaohsiung 833, Taiwan.
C3 Chang Gung Memorial Hospital; Chang Gung University; Chang Gung Memorial
   Hospital; Chang Gung Memorial Hospital
RP Chan, JYH (corresponding author), Chang Gung Univ, Coll Med, Kaohsiung 833, Taiwan.
EM tainyl@hotmail.com; dinor666@ms32.hinet.net; wlh0701@yahoo.com;
   leu@mail.cgu.edu.tw; jchan@adm.cgmh.org.tw
RI Wu, Kay/ACD-1767-2022; Leu, Steve/D-6807-2011; Chan, Julie/X-5253-2019;
   Tain, You-Lin/H-2827-2019
OI Wu, Kay L.H./0000-0002-7297-6788; Tain, You-Lin/0000-0002-7059-6407;
   Lee, Wei-Chia/0000-0003-0701-2285
FU Chang Gung Memorial Hospital, Kaohsiung, Taiwan [CMRPG8F0022,
   CMRPG8G0191]
FX This work was supported by grants (CMRPG8F0022 and CMRPG8G0191) from
   Chang Gung Memorial Hospital, Kaohsiung, Taiwan.
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NR 28
TC 32
Z9 33
U1 1
U2 9
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JAN
PY 2018
VL 10
IS 1
AR 56
DI 10.3390/nu10010056
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA FU8FF
UT WOS:000424088000056
PM 29315230
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Riojas-Hernández, A
   Bernal-Ramírez, J
   Rodríguez-Mier, D
   Morales-Marroquín, FE
   Domínguez-Barragán, EM
   Borja-Villa, C
   Rivera-Alvarez, I
   García-Rivas, G
   Altamirano, J
   García, N
AF Riojas-Hernandez, Adriana
   Bernal-Ramirez, Judith
   Rodriguez-Mier, David
   Morales-Marroquin, Flor E.
   Dominguez-Barragan, Elvia M.
   Borja-Villa, Cuauhtemoc
   Rivera-Alvarez, Irais
   Garcia-Rivas, Gerardo
   Altamirano, Julio
   Garcia, Noemi
TI Enhanced oxidative stress sensitizes the mitochondrial permeability
   transition pore to opening in heart from Zucker Fa/fa rats with type 2
   diabetes
SO LIFE SCIENCES
LA English
DT Article
DE Mitochondrial dysfunction; Calcium; Diastolic dysfunction;
   Cardiovascular disease; Obesity
ID CYTOCHROME-C RELEASE; SARCOPLASMIC-RETICULUM; VENTRICULAR MYOCYTES;
   NUCLEOTIDE TRANSLOCASE; ALTERED MECHANISMS; METABOLIC SYNDROME; CHANGING
   PATTERN; OBESE RATS; CELL-DEATH; APOPTOSIS
AB Aims: Obesity and diabetes mellitus type 2 (DM2) frequently coexist and increase the propensity of cardiovascular dysfunction by numerous mechanisms. Chief among them are oxidative stress and Ca2+ dysregulation, and both are inducers of the mitochondrial permeability transition pore (MPTP). Nevertheless, it is unknown whether MPTP formation is triggered in DM2 animals, and thereby contributing to cardiac dysfunction. We assessed MPTP sensitivity and reactive oxygen species production in cardiac mitochondria, as well as cytosolic Ca2+ handling in ventricular myocytes from rats with DM2.
   Main methods: Male Zucker Fa/fa rats (Fa/fa) 32 weeks old presenting DM2, concentric hypertrophy, and diastolic dysfunction were used. MPTP formation was evaluated in isolated mitochondria and Ca2+ handling in ventricular myocytes, by spectrophotometric and confocal microscope techniques, respectively.
   Key findings: We found that the systolic Ca2+ transient relaxation was similar to 40% slower, while mitochondrial H2O2 production increased by similar to 6-fold. MPTP opening in isolated mitochondria from Fa/fa (mFa/fa) was more sensitive to Ca2+ than in mitochondria from lean rats (mLean), and correlated with increased thiol group exposure. The mFa/fa showed decreased oxidative phosphorylation capacity. The ATP content decreased in myocytes, while the PCr/ATP ratio remained unchanged and caspase 9 activity largely increased in myocytes from Fa/fa animals.
   Significance: Our results showed that oxidative stress and diastolic Ca2+ dysregulation increased MPTP sensitivity leading to mitochondrial dysfunction and apoptosis. Mitochondrial dysfunction could compromise ATP synthesis, and lower ATP could be linked to decreased SERCA2 activity, which might underlie diastolic dysfunction. Prolonged Ca2+ transients might further exacerbate mitochondrial dysfunction. (C) 2015 Elsevier Inc. All rights reserved.
C1 [Riojas-Hernandez, Adriana; Bernal-Ramirez, Judith; Rodriguez-Mier, David; Morales-Marroquin, Flor E.; Dominguez-Barragan, Elvia M.; Borja-Villa, Cuauhtemoc; Rivera-Alvarez, Irais; Garcia-Rivas, Gerardo; Altamirano, Julio; Garcia, Noemi] Tecnol Monterrey, Escuela Nacl Med, Cardiol & Med Vasc, Monterrey, NL, Mexico.
   [Garcia-Rivas, Gerardo; Altamirano, Julio; Garcia, Noemi] Tecnol Monterrey, Ctr Invest Basica & Transferencia, Hosp Zambrano Hellion, San Pedro Garza Garcia 66278, Nuevo Leon, Mexico.
C3 Tecnologico de Monterrey; Tecnologico de Monterrey
RP García, N (corresponding author), Tecnol Monterrey, Escuela Nacl Med, Hosp Zambrano Hellion, Batallon San Patricio 112, San Pedro Garza Garcia 66278, Nuevo Leon, Mexico.
EM garcianr@itesm.mx
RI Garcia, Noemi/T-4688-2019; García-Rivas, Gerardo/F-5994-2012;
   Altamirano, Julio/F-8280-2019; Morales Marroquin, Flor
   Elisa/Q-4910-2018; Garcia-Rivas, Gerardo/A-9691-2011
OI Noemi, Garcia/0000-0002-1137-0117; Borja Villa,
   Cuauhtemoc/0000-0001-5404-7638; Morales Marroquin, Flor
   Elisa/0000-0002-6849-1657; Altamirano, Julio/0000-0003-4652-2245;
   Garcia-Rivas, Gerardo/0000-0003-4731-3293; Bernal-Ramirez,
   Judith/0000-0003-1223-7366
FU Endowed Chair in Cardiology-Tecnologico de Monterrey [CAT-131]; Consejo
   Nacional de Ciencia y Tecnologia-Mexico (CONACyT) [181460, 156717,
   151136]; Xignus-Metabolic Syndrome/Obesity Chair; CONACyT; Tecnologico
   de Monterrey scholarships
FX This work was partially supported by the Endowed Chair in
   Cardiology-Tecnologico de Monterrey CAT-131, as well as by the Consejo
   Nacional de Ciencia y Tecnologia-Mexico (CONACyT) grants 181460 (N.G.),
   156717 (J.A.) and 151136 (SSA/IMSS/ISSSTE) (G. G-R) and Xignus-Metabolic
   Syndrome/Obesity Chair. ARH and JB were supported by CONACyT and
   Tecnologico de Monterrey scholarships. We also would like to thank
   Roxana Alicia Rivera, Ph.D. for skillful technical support.
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NR 78
TC 34
Z9 36
U1 0
U2 13
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0024-3205
EI 1879-0631
J9 LIFE SCI
JI Life Sci.
PD NOV 15
PY 2015
VL 141
BP 32
EP 43
DI 10.1016/j.lfs.2015.09.018
PG 12
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA CX3XN
UT WOS:000365632900006
PM 26407476
DA 2025-06-11
ER

PT J
AU Vieira, VJ
   Valentine, RJ
   McAuley, E
   Evans, E
   Woods, JA
AF Vieira, Victoria J.
   Valentine, Rudy J.
   McAuley, Edward
   Evans, Ellen
   Woods, Jeffrey A.
TI Independent relationship between heart rate recovery and C-reactive
   protein in older adults
SO JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
LA English
DT Article
DE parasympathetic tone; fitness; obesity; inflammation; aging
ID TIME PHYSICAL-ACTIVITY; CARDIORESPIRATORY FITNESS; INFLAMMATORY MARKERS;
   CARDIOVASCULAR-DISEASE; COAGULATION MARKERS; METABOLIC SYNDROME;
   RATE-VARIABILITY; MENTAL STRESS; EXERCISE; ASSOCIATIONS
AB OBJECTIVES: To examine the independent effect of parasympathetic tone (PST), assessed here according to heart rate recovery (HRR) after exercise, on circulating levels of C-reactive protein (CRP) in 132 elderly participants.
   DESIGN: Cross-sectional analysis using baseline data from an ongoing trial assessing the effects of exercise on immune function.
   SETTING: Champaign/Urbana, Illinois, vicinity.
   PARTICIPANTS: Community-living older adults who had been sedentary for 6 months or longer. Major exclusion criteria were current use of medications that could interfere with immunity, severe arthritis, history of cancer or inflammatory disease, recent illness or vaccination, and smoking.
   MEASUREMENTS: Participants were assessed for serum CRP (using enzyme-linked immunosorbent assay), cardiorespiratory fitness (peak oxygen intake (VO2)), HRR, percentage body fat (using dual-energy x-ray absorptiometry), physical activity level (according to the Physical Activity Scale for the Elderly (PASE)), fasting plasma glucose, kidney function (creatinine level), and perceived stress.
   RESULTS: Mean CRP level +/- standard deviation was 3.81 +/- 2.7 mg/L, placing this group in a high-risk category. After adjusting for the effects of body fat (34.6%+/- 7.4%), aspirin use, VO2 peak (19.5 +/- 3.9 mL oxygen/kg per minute), PASE, sex (64% women), and perceived stress, HRR was the only independent predictor of CRP (beta=-0.257, P=.003, change in coefficient of determination=0.060).
   CONCLUSION: HRR after exercise appears to be independently associated with lower CRP in older sedentary individuals, suggesting that the parasympathetic nervous system is involved in regulating chronic inflammation in older adults. Improvements in PST, as a result of regular physical exercise, may contribute to the antiinflammatory effects of exercise, independent of physical fitness or fatness.
C1 Univ Illinois, Dept Kinesiol & Community Hlth, Urbana, IL 61801 USA.
   Univ Illinois, Div Nutr Sci, Urbana, IL 61801 USA.
C3 University of Illinois System; University of Illinois Urbana-Champaign;
   University of Illinois System; University of Illinois Urbana-Champaign
RP Woods, JA (corresponding author), Univ Illinois, Dept Kinesiol & Community Hlth, 906 S Goodwin Ave, Urbana, IL 61801 USA.
EM Woods1@uiuc.edu
RI McAuley, Edward/A-9508-2008
OI Vieira-Potter, Victoria/0000-0001-7563-0806
FU NIA NIH HHS [AG-18861] Funding Source: Medline; NIDDK NIH HHS
   [T32DK59802] Funding Source: Medline
CR [Anonymous], 2006, ACSMS GUIDELINES EXE, V7th
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NR 28
TC 21
Z9 23
U1 0
U2 4
PU BLACKWELL PUBLISHING
PI OXFORD
PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND
SN 0002-8614
J9 J AM GERIATR SOC
JI J. Am. Geriatr. Soc.
PD MAY
PY 2007
VL 55
IS 5
BP 747
EP 751
DI 10.1111/j.1532-5415.2007.01160.x
PG 5
WC Geriatrics & Gerontology; Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA 161RA
UT WOS:000246031900014
PM 17493195
DA 2025-06-11
ER

PT J
AU Tannous, A
   Bradford, AP
   Kuhn, K
   Fought, A
   Schauer, I
   Santoro, N
AF Tannous, Andrew
   Bradford, Andrew P.
   Kuhn, Katherine
   Fought, Angela
   Schauer, Irene
   Santoro, Nanette
TI A randomised trial examining inflammatory signaling in acutely induced
   hyperinsulinemia and hyperlipidemia in normal weight women-the
   reprometabolic syndrome
SO PLOS ONE
LA English
DT Article
ID ENDOPLASMIC-RETICULUM STRESS; GROWTH-FACTOR 21; FATTY-ACIDS; OBESITY;
   DYSFUNCTION; INDUCTION; SECRETION
AB Context Obesity, is a state of chronic inflammation, characterized by elevated lipids, insulin resistance and relative hypogonadotropic hypogonadism. We have defined the accompanying decreased Luteinizing Hormone (LH), Follicle-Stimulating Hormone (FSH), ovarian steroids and reduced pituitary response to Gonadotropin-releasing Hormone (GnRH) as Reprometabolic syndrome, a phenotype that can be induced in healthy normal weight women (NWW) by acute infusion of free fatty acids and insulin.
   Objective To identify potential mediators of insulin and lipid-related reproductive endocrine dysfunction.
   Design, setting, participants Secondary analysis of crossover study of eumenorrheic reproductive aged women of normal Body Mass Index (BMI) (< 25 kg/m(2)) at an academic medical center.
   Intervention Participants underwent 6-hour infusions of either saline/heparin or insulin plus fatty acids (Intralipid plus heparin), in the early follicular phase of sequential menstrual cycles, in random order. Euglycemia was maintained by glucose infusion. Frequent blood samples were obtained.
   Main outcome measures Pooled serum from each woman was analyzed for cytokines, interleukins, chemokines, adipokines, Fibroblast Growth Factor-21 (FGF-21) and markers of endoplasmic reticulum (ER) stress (CHOP and GRP78). Wilcoxon signed-rank tests were used to compare results across experimental conditions.
   Results Except for Macrophage Inflammatory Protein-1 beta (MIP-1 beta), no significant differences were observed in serum levels of any of the inflammatory signaling or ER stress markers tested.
   Conclusion Acute infusion of lipid and insulin, to mimic the metabolic syndrome of obesity, was not associated with an increase in inflammatory markers. These results imply that the endocrine disruption and adverse reproductive outcomes of obesity are not a consequence of the ambient inflammatory environment but may be mediated by direct lipotoxic effects on the hypothalamic-pituitary-ovarian (HPO) axis.
C1 [Tannous, Andrew; Bradford, Andrew P.; Kuhn, Katherine; Fought, Angela; Santoro, Nanette] Univ Colorado, Dept Obstet & Gynecol, Div Endocrinol Metab & Diabet, Sch Med, Aurora, CO 80045 USA.
   [Schauer, Irene] Univ Colorado, Dept Med, Div Endocrinol Metab & Diabet, Sch Med, Aurora, CO USA.
   [Schauer, Irene] Rocky Mt Reg Vet Affairs Med Ctr, Endocrinol Sect, Aurora, CO USA.
C3 University of Colorado System; University of Colorado Anschutz Medical
   Campus; University of Colorado System; University of Colorado Anschutz
   Medical Campus
RP Santoro, N (corresponding author), Univ Colorado, Dept Obstet & Gynecol, Div Endocrinol Metab & Diabet, Sch Med, Aurora, CO 80045 USA.
EM Nanette.Santoro@cuanschutz.edu
OI Santoro, Nanette/0000-0001-9096-7490; Schauer, Irene/0000-0003-0575-7566
FU NIH [R01HD0087314]; University of Colorado Clinical Translational
   Research Center [UL1 RR02578]
FX The work was supported by: NIH R01HD0087314 to NS The funders had no
   role in study design, data collection and analysis, decision to publish,
   or preparation of the manuscript. There was no additional external
   funding received for this study. The authors acknowledge the assistance
   of the University of Colorado Clinical Translational Research Center
   (UL1 RR02578) and the Human Immune Monitoring Shared Resources Services.
   We thank Dr. Josiane Broussard (Colorado State University) for help with
   euglycemic clamps.
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   Singhal G, 2016, MOL METAB, V5, P690, DOI 10.1016/j.molmet.2016.05.010
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NR 33
TC 5
Z9 7
U1 2
U2 4
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAR 25
PY 2021
VL 16
IS 3
AR e0247638
DI 10.1371/journal.pone.0247638
PG 12
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA RF4TN
UT WOS:000634832800022
PM 33764994
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Ridlo, M
   Putra, IB
   Jusuf, NK
AF Ridlo, Muhammad
   Putra, Imam Budi
   Jusuf, Nelva Karmila
TI Analysis of Malondialdehyde (MDA) levels in skin tags patients
SO BALI MEDICAL JOURNAL
LA English
DT Article
DE skin tags; malondialdehyde; oxidative stress
ID METABOLIC SYNDROME; ASSOCIATION; LEPTIN
AB Background: Skin tags (known as acrochordon) are the most common benign skin tumors, usually skin-colored or hyperpigmented, found in the natural folds of the skin. They have been associated with various clinical conditions. A few studies results have been reported regarding the oxidative stress are strongly associated with skin tumor. Malondialdehyde (MDA) is an end product of lipid peroxidation by free radicals in the body. MDA assay is widely used as a biomarker to evaluate systemic oxidative stress in biomedical fields. This study evaluated the difference in serum MDA level in skin tags patients and control.
   Methods: This study is an analytic observational study with a cross-sectional design, including 40 patients with skin tags and 40 healthy volunteer controls, based on inclusion and exclusion criteria. Age, sex, and family history of skin tags were estimated on the patients. Diagnosis of skin tags was made based on history and clinical examination. Measurement of MDA level by enzyme-linked immunosorbent assay (ELISA) to the patients and controls. Mann-Whitney test is used to determine the differences in serum MDA levels. The results were significant, with a p-value<0.05.
   Results: Mean MDA level of skin tags patients was highest at age 50-59 years (27,01 +/- 10,87 nmol/ml). The mean MDA level of male skin tag patients (15,99 +/- 8,23 nmol/ml) was higher than females (15,23 +/- 8,17 nmol/ml). The mean MDA level of skin tag patients with a family history (19,77 +/- 7,92 nmol/ml) was higher compared to patients without a family history (11,82 +/- 8,48 nmol/ml). The mean of MDA level was significantly higher in the skin tags group (15,81 +/- 8,23 nmol/ml) than the control group (8,86 +/- 7,02ng/ml) with p = 0.032.
   Conclusion: There were higher significant differences in serum MDA levels in the skin tags patients than in control.
C1 [Ridlo, Muhammad] Univ Sumatera Utara, Univ Sumatera Utara Hosp, Fac Med, Clin Med,Dept Dermatol & Venereol, Medan, Indonesia.
   [Putra, Imam Budi; Jusuf, Nelva Karmila] Univ Sumatera Utara, Univ Sumatera Utara Hosp, Fac Med, Dept Dermatol & Venereol, Medan, Indonesia.
C3 University of North Sumatra; University of North Sumatra
RP Ridlo, M (corresponding author), Univ Sumatera Utara, Univ Sumatera Utara Hosp, Fac Med, Clin Med,Dept Dermatol & Venereol, Medan, Indonesia.
EM ridlotea@gmail.com
RI Jusuf, Nelva/Q-5969-2019; Putra, Budi/T-9448-2019
OI Ridlo, Muhammad/0000-0001-9055-3087
CR Akbulut H, 2003, CANCER DETECT PREV, V27, P122, DOI 10.1016/S0361-090X(03)00029-1
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NR 28
TC 1
Z9 1
U1 1
U2 5
PU UNIV UDAYANA
PI BALI
PA KAMPUS UNUD SUDIRMAN, DENPASAR, BALI, 00000, INDONESIA
SN 2089-1180
EI 2302-2914
J9 BALI MED J
JI Bali Med. J.
PY 2021
VL 10
IS 1
BP 296
EP 299
DI 10.15562/bmj.v10i1.2214
PG 4
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA SI2XO
UT WOS:000654690200041
OA gold
DA 2025-06-11
ER

PT J
AU Thomas, MM
   Zaki, ME
   Youness, E
   Hamed, K
   Khedr, AA
   Abd El-Massieh, PM
   Abdo, SM
   El-Bassyouni, HT
AF Thomas, Manal M.
   Zaki, Moushira E.
   Youness, Eman
   Hamed, Khaled
   Khedr, Azzah A.
   Abd El-Massieh, Phoebe M.
   Abdo, Sara M.
   El-Bassyouni, Hala T.
TI Measurement of Serum Chemerin, Oxidized LDL, and Vitamin D Levels in
   Prader-Willi Syndrome: A Cross-Sectional Study in Pediatric Egyptian
   Patients
SO JOURNAL OF CHILD SCIENCE
LA English
DT Article
DE PWS; chemerin; oxidized LDL; 25 hydroxy vitamin D; BMI
ID BODY-MASS-INDEX; GROWTH-HORMONE DEFICIENCY; LOW-DENSITY-LIPOPROTEIN;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; CARDIOVASCULAR RISK;
   ADIPOSE-TISSUE; KNOCKOUT MICE; WEIGHT-LOSS; INFLAMMATION
AB Prader-Willi syndrome (PWS) is the commonest genetic cause of obesity. Oxidative stress and chronic low-grade inflammation play a crucial role in the pathogenesis of obesity. Alterations of vitamin D (25-OHD) levels are commonly encountered with obesity. The aim of this study was to analyze serum chemerin, oxidized low-density lipoprotein (ox-LDL), and 25-OHD values in pediatric PWS patients in comparison with obese healthy children and nonobese control groups, highlighting possible correlations with body mass index (BMI) and obesity. Twenty-six PWS Egyptian patients and 26 obese healthy individuals referred to the outpatient clinic of the Clinical Genetics Department, National Research Centre, Cairo, Egypt, and 20 control patients with matching age and sex were enrolled in the study. Patients were clinically diagnosed and confirmed by routine cytogenetic and fluorescence in-situ hybridization analysis. Anthropometric measurements were performed, and BMI was calculated by weight/height(2) (kg/m(2)), and BMI z score was also determined. Serum chemerin, ox-LDL, and vitamin D were determined by enzyme-linked immunosorbent assay. Chemerin levels, which reflected chronic inflammation, were significantly elevated as compared with obese and nonobese controls (p <= 0.0001). Concerning oxidative damage, children with PWS showed higher Ox-LDL levels compared with obese and nonobese controls (p < 0.0001). Vitamin D levels were significantly lower in PWS patients compared with obese and nonobese controls (p <= 0.0001). Our data showed that obesity in PWS is associated with oxidative stress and chronic low-grade inflammation. Ox-LDL is a good indicator of oxidative stress, and chemerin could be used as a biomarker for the chronic inflammatory state. Furthermore, vitamin D supplementation is recommended in PWS patients
C1 [Thomas, Manal M.; Hamed, Khaled; El-Bassyouni, Hala T.] Natl Res Ctr, Ctr Sci Excellence, Dept Clin Genet, Cairo, Egypt.
   [Zaki, Moushira E.; Youness, Eman] Natl Res Ctr, Dept Biol Anthropol, Cairo, Egypt.
   [Khedr, Azzah A.] Natl Res Ctr, Human Genet & Genome Res Div, Human Cytogenet Dept, Cairo, Egypt.
   [Abd El-Massieh, Phoebe M.] Natl Res Ctr, Human Genet & Genome Res Div, Orodental Genet Dept, Cairo, Egypt.
   [Abdo, Sara M.] Helwan Univ, Div Biochem, Dept Chem, Fac Sci, Cairo, Egypt.
C3 Egyptian Knowledge Bank (EKB); National Research Centre (NRC); Egyptian
   Knowledge Bank (EKB); National Research Centre (NRC); Egyptian Knowledge
   Bank (EKB); National Research Centre (NRC); Egyptian Knowledge Bank
   (EKB); National Research Centre (NRC); Egyptian Knowledge Bank (EKB);
   Helwan University
RP Thomas, MM (corresponding author), Natl Res Ctr, Dept Clin Genet, Human Genet & Genome Res Div, 33rd El Bohouth St, Giza 12622, Egypt.
EM nula_m@hotmail.com
RI Thomas, Manal/E-9816-2018; Khedr, Abdalla/AFL-8144-2022; Abdo,
   Sara/AAW-6327-2020; Alyoubi, Khaled/GPX-8364-2022; El-Bassyouni,
   Hala/A-1955-2016
OI El-Bassyouni, Hala/0000-0001-9825-1219
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NR 84
TC 1
Z9 1
U1 0
U2 0
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 2474-5871
J9 J CHILD SCI
JI J. Child. Sci.
PD JAN
PY 2020
VL 10
IS 1
BP E187
EP E195
DI 10.1055/s-0040-1718896
PG 9
WC Pediatrics
WE Emerging Sources Citation Index (ESCI)
SC Pediatrics
GA PA8JF
UT WOS:000595875000020
OA hybrid
DA 2025-06-11
ER

PT J
AU Koohdani, F
   Sadrzadeh-Yeganeh, H
   Djalali, M
   Eshraghian, M
   Keramat, L
   Mansournia, MA
   Zamani, E
AF Koohdani, Fariba
   Sadrzadeh-Yeganeh, Haleh
   Djalali, Mahmoud
   Eshraghian, Mohammadreza
   Keramat, Laleh
   Mansournia, Mohammad-Ali
   Zamani, Elham
TI Association between ApoA-II-265 T/C polymorphism and oxidative stress in
   patients with type 2 diabetes mellitus
SO JOURNAL OF DIABETES AND ITS COMPLICATIONS
LA English
DT Article
DE ApoA-II polymorphism; Oxidative stress; Diabetes; Obesity;
   Cardiovascular disease
ID APOLIPOPROTEIN-A-II; HIGH-DENSITY-LIPOPROTEIN; CORONARY-ARTERY-DISEASE;
   C-REACTIVE PROTEIN; BODY-MASS INDEX; HEART-DISEASE; ANTIOXIDANT
   PROPERTIES; LIPID-PEROXIDATION; METABOLIC SYNDROME; FOLLOW-UP
AB Background: Apolipoprotein A-II (ApoA-II) constitutes approximately 20% of the total HDL protein content. The results of various studies on the relationship between cardiovascular diseases (CVD) and the plasma ApoA-II level are contradictory. The aim of this study was to determine the relationship between ApoA-II polymorphism and oxidative stress (OS) as a risk factor for CVD.
   Methods: The present comparative study was carried out on 180 obese and non-obese patients with type 2 diabetes, with equal numbers of CC, TC, and TT genotypes of ApoA-II -265 T/C gene. The ApoA-II genotype was determined by the TaqMan assay method. The anthropometric measurements and serum levels of lipid profile, superoxide dismutase activity (SOD), total antioxidant capacity (TAC), and 8-isoprostaneF2 alpha were measured.
   Results: After adjusting for confounding factors, in the total study population and in obese and non-obese groups, the subjects with CC genotype had a lower mean serum SOD activity (p = 0.002, p = 0.007 and p = 0.005, respectively) and higher mean 8-isoprostaneF2 alpha concentration (p < 0.001, p = 0.003 and p = 0.004, respectively) than the T-allele carriers. In the TT/TC group, the mean 8-isoprostanF2 alpha concentration was significantly higher in the obese subjects than the non-obese subjects (p = 0.009). In the CC group, no significant differences were found in the OS factors between obese and non-obese groups.
   Conclusion: The T allele in patients with type 2 diabetes is a protective factor against OS; obesity inhibits this protective effect. The results of this study represent the anti-atherogenic properties of ApoA-II. However, further studies are needed in this field. (C) 2015 Elsevier Inc. All rights reserved.
C1 [Koohdani, Fariba; Djalali, Mahmoud; Keramat, Laleh; Zamani, Elham] Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Cellular & Mol Nutr, Tehran, Iran.
   [Sadrzadeh-Yeganeh, Haleh] Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Community Nutr, Tehran, Iran.
   [Eshraghian, Mohammadreza; Mansournia, Mohammad-Ali] Univ Tehran Med Sci, Sch Publ Hlth, Dept Biostat & Epidemiol, Tehran, Iran.
   [Koohdani, Fariba] Univ Tehran Med Sci, Endocrinol & Metab Clin Sci Inst, Diabet Res Ctr, Tehran, Iran.
C3 Tehran University of Medical Sciences; Tehran University of Medical
   Sciences; Tehran University of Medical Sciences; Tehran University of
   Medical Sciences
RP Zamani, E (corresponding author), Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Cellular & Mol Nutr, 44,Hojjat Dost Alley,Naderi St,Keshavarz Blvd, Tehran, Iran.
EM elh.zamani@yahoo.com
RI mansournia, Mohammad/AFA-8899-2022; Koohdani, Fariba/D-1298-2018
OI Mansournia, Mohammad Ali/0000-0003-3343-2718; Koohdani,
   Fariba/0000-0002-7108-5350
FU Tehran University of Medical Sciences [20414]
FX This research has been supported by Tehran University of Medical
   Sciences grant no. 20414.
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NR 47
TC 8
Z9 8
U1 0
U2 4
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1056-8727
EI 1873-460X
J9 J DIABETES COMPLICAT
JI J. Diabetes Complications
PD SEP-OCT
PY 2015
VL 29
IS 7
BP 908
EP 912
DI 10.1016/j.jdiacomp.2015.05.024
PG 5
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA CQ4UG
UT WOS:000360599500010
PM 26104730
DA 2025-06-11
ER

PT J
AU Gao, HT
   Zeng, ZG
   Zhang, H
   Zhou, XL
   Guan, LC
   Deng, WP
   Xu, LS
AF Gao, Huiting
   Zeng, Zhigang
   Zhang, Han
   Zhou, Xiaoli
   Guan, Lichang
   Deng, Weiping
   Xu, Lishu
TI The Glucagon-Like Peptide-1 Analogue Liraglutide Inhibits Oxidative
   Stress and Inflammatory Response in the Liver of Rats with Diet-Induced
   Non-alcoholic Fatty Liver Disease
SO BIOLOGICAL & PHARMACEUTICAL BULLETIN
LA English
DT Article
DE liraglutide; non-alcoholic fatty liver disease; oxidative stress;
   inflammatory response; adiponectin
ID INSULIN-RESISTANCE; HEPATIC STEATOSIS; TNF-ALPHA; SUPEROXIDE-DISMUTASE;
   METABOLIC SYNDROME; ENDOTHELIAL-CELLS; RECEPTOR AGONIST; MOUSE MODEL;
   OBESITY; ADIPONECTIN
AB Liraglutide, a glucagon-like peptide-1 (GLP-1) analogue, has been demonstrated to reduce hepatic steatosis. However, the mechanism of the lipid-lowering effect of liraglutide in the liver remains unclear. The aim of the present study was to investigate the beneficial effect of liraglutide on diet-induced non-alcoholic fatty liver disease (NAFLD) and the underlying mechanism in rats. NAFLD was induced in Sprague-Dawley rats by feeding a high fat and high cholesterol (HFHC) diet. Liraglutide (0.6 mg/kg body weight/d) was injected intraperitoneally to the rats subjected to HFHC diet four weeks before sacrificing the animals. Body and liver weight, fasting blood glucose (FBG), fasting insulin, serum aminotransferase (ALT) and lipid accumulation in the liver were determined. Markers of oxidative stress, such as malondialdehyde (MDA), free fatty acid (FFAs), superoxide dismutase (SOD), and pro-inflammatory cytokine tumor necrosis factor-alpha (TNF-alpha) were detected by colorimetric detection or enzyme-linked immunosorbent assay (ELISA). Serum and hepatic adiponectin were measured by ELISA. The expression of c-Jun N-terminal kinase-1 (JNK-1) and phosphorylated JNK-1 were examined by Western blotting. Liraglutide improved insulin resistance, decreased hepatic steatosis and reversed liver dysfunction. The hepatic levels of MDA, FFAs, and TNF-alpha were significantly decreased versus controls. Meanwhile, administration of liraglutide significantly increased SOD and adiponectin levels in the liver and inhibited the expression of JNK-1 and phosphorylated JNK-1 versus control rats. Liraglutide exerted anti-oxidative and anti-inflammatory effects in the liver and consequently reversed hepatic steatosis and insulin resistance. Such effects might be mediated by the elevation of adiponectin levels and the inactivation of JNK-1.
C1 [Gao, Huiting; Zeng, Zhigang; Zhang, Han; Zhou, Xiaoli; Guan, Lichang; Deng, Weiping; Xu, Lishu] Guangdong Acad Med Sci, Guangdong Gen Hosp, Dept Gastroenterol, Inst Geriatr, Guangzhou 510080, Guangdong, Peoples R China.
C3 Southern Medical University - China; Guangdong Academy of Medical
   Sciences & Guangdong General Hospital
RP Xu, LS (corresponding author), Guangdong Acad Med Sci, Guangdong Gen Hosp, Dept Gastroenterol, Inst Geriatr, Guangzhou 510080, Guangdong, Peoples R China.
EM xulishu70@163.com
RI Zhou, Xiaoli/HME-2175-2023; Deng, Weiping/F-3486-2015
FU Natural Science Foundation of Guangdong Province [10151008008000003,
   S201201001095]
FX This work was supported by Research Grants from the Natural Science
   Foundation of Guangdong Province (No. 10151008008000003 and No.
   S201201001095).
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NR 59
TC 56
Z9 67
U1 0
U2 17
PU PHARMACEUTICAL SOC JAPAN
PI TOKYO
PA 2-12-15 SHIBUYA, SHIBUYA-KU, TOKYO, 150-0002, JAPAN
SN 0918-6158
J9 BIOL PHARM BULL
JI Biol. Pharm. Bull.
PD MAY
PY 2015
VL 38
IS 5
BP 694
EP 702
DI 10.1248/bpb.b14-00505
PG 9
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA CH2LD
UT WOS:000353855800010
PM 25947915
OA gold
DA 2025-06-11
ER

PT J
AU de la Monte, SM
   Tong, M
AF de la Monte, Suzanne M.
   Tong, Ming
TI Brain metabolic dysfunction at the core of Alzheimer's disease
SO BIOCHEMICAL PHARMACOLOGY
LA English
DT Review
DE Alzheimer's disease; Insulin resistance; Type 3 diabetes; Ceramides;
   Nitrosamines; Obesity; Metabolic syndrome; Non-alcoholic fatty liver
   disease; Lifestyle
ID FATTY LIVER-DISEASE; TYPE-2 DIABETES-MELLITUS; GROWTH-FACTOR EXPRESSION;
   ENDOPLASMIC-RETICULUM STRESS; CEREBRAL GLUCOSE-UTILIZATION; BODY-MASS
   INDEX; INSULIN-RESISTANCE; OXIDATIVE STRESS; NONALCOHOLIC
   STEATOHEPATITIS; LIPID-METABOLISM
AB Growing evidence supports the concept that Alzheimer's disease (AD) is fundamentally a metabolic disease with molecular and biochemical features that correspond with diabetes mellitus and other peripheral insulin resistance disorders. Brain insulin/IGF resistance and its consequences can readily account for most of the structural and functional abnormalities in AD. However, disease pathogenesis is complicated by the fact that AD can occur as a separate disease process, or arise in association with systemic insulin resistance diseases, including diabetes, obesity, and non-alcoholic fatty liver disease. Whether primary or secondary in origin, brain insulin/IGF resistance initiates a cascade of neurodegeneration that is propagated by metabolic dysfunction, increased oxidative and ER stress, neuro-inflammation, impaired cell survival, and dysregulated lipid metabolism. These injurious processes compromise neuronal and glial functions, reduce neurotransmitter homeostasis, and cause toxic oligomeric pTau and (amyloid beta peptide of amyloid beta precursor protein) A beta PP-A beta fibrils and insoluble aggregates (neurofibrillary tangles and plaques) to accumulate in brain. AD progresses due to: (1) activation of a harmful positive feedback loop that progressively worsens the effects of insulin resistance; and (2) the formation of ROS- and RNS-related lipid, protein, and DNA adducts that permanently damage basic cellular and molecular functions. Epidemiologic data suggest that insulin resistance diseases, including AD, are exposure-related in etiology. Furthermore, experimental and lifestyle trend data suggest chronic low-level nitrosamine exposures are responsible. These concepts offer opportunities to discover and implement new treatments and devise preventive measures to conquer the AD and other insulin resistance disease epidemics. (C) 2013 Elsevier Inc. All rights reserved.
C1 [de la Monte, Suzanne M.] Rhode Isl Hosp, Dept Pathol Neuropathol, Providence, RI 02903 USA.
   [de la Monte, Suzanne M.; Tong, Ming] Brown Univ, Warren Alpert Med Sch, Providence, RI 02912 USA.
   [de la Monte, Suzanne M.] Rhode Isl Hosp, Dept Neurol, Providence, RI 02903 USA.
   [de la Monte, Suzanne M.] Rhode Isl Hosp, Dept Neurosurg, Providence, RI 02903 USA.
   [de la Monte, Suzanne M.; Tong, Ming] Rhode Isl Hosp, Dept Med, Providence, RI 02903 USA.
C3 Lifespan Health Rhode Island; Rhode Island Hospital; Brown University;
   Lifespan Health Rhode Island; Rhode Island Hospital; Lifespan Health
   Rhode Island; Rhode Island Hospital; Lifespan Health Rhode Island; Rhode
   Island Hospital
RP de la Monte, SM (corresponding author), Rhode Isl Hosp, Pierre Galletti Res Bldg,55 Claverick St,Rook 419, Providence, RI 02903 USA.
EM Suzanne_DeLaMonte_MD@Brown.edu
RI de la monte, suzanne/L-7670-2019
FU National Institutes of Health [AA-11431, AA-12908]
FX Funding sources are Grants AA-11431 and AA-12908 from the National
   Institutes of Health.
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NR 208
TC 341
Z9 370
U1 7
U2 184
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0006-2952
EI 1873-2968
J9 BIOCHEM PHARMACOL
JI Biochem. Pharmacol.
PD APR 15
PY 2014
VL 88
IS 4
SI SI
BP 548
EP 559
DI 10.1016/j.bcp.2013.12.012
PG 12
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Pharmacology & Pharmacy
GA AF8PF
UT WOS:000334977400013
PM 24380887
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Inami, N
   Nomura, S
   Inami, O
   Kimura, Y
   Urase, F
   Maeda, Y
   Iwasaka, T
AF Inami, Norihito
   Nomura, Shosaku
   Inami, Osamu
   Kimura, Yutaka
   Urase, Fumiaki
   Maeda, Yasuhiro
   Iwasaka, Toshiji
TI Significance of soluble CD40 ligand, adiponectin and reactive oxygen
   metabolites in aging
SO ARCHIVES OF GERONTOLOGY AND GERIATRICS
LA English
DT Article
DE Soluble CD40 ligand; Adiponectin; Aging; American football player;
   Oxidative stress; Insulin resistance
ID INSULIN-RESISTANCE; OBESE WOMEN; INFLAMMATORY MARKERS; NITRIC-OXIDE;
   WEIGHT-LOSS; AEROBIC EXERCISE; HYPOADIPONECTINEMIA; RESPONSES; GENE; FAT
AB We analyzed the association between platelet activation, adiponectin, insulin resistance and oxidative stress in aging. In addition, we included American football (AB) players to investigate whether this association is modulated by exercise. Eighty-six old age patients (>= 65 years old) hospitalized at the nursing institution and 62 AB players were recruited as study subjects. Reactive oxygen metabolites (ROM), soluble CD40 ligand (sCD40L) and adiponectin were estimated with these patients. In comparison to old age, plasma adiponectin levels in AB players were significantly low. In addition, the adiponectin values of elder group (>80 years) in old age were significantly increased higher than those for Younger group (<= 80 years). There were no differences of sCD40L in two groups. Levels of ROM in AB players were also significantly lower than that in old age. However, the ROM values of younger group in old age were significantly increased higher than those for elder group. The sCD40L also exhibited the same results. There were no significant differences in ROM and adiponectin levels between the high homeostasis model assessment-insulin resistance (HOMA-IR) (>2.0) and the low HOMA-IR (<= 2.0). In contrast, in the old age, the sCD40L and ROM levels in the high HOMA-IR group were significantly higher than those in the low HOMA-IR group. In addition, the adiponectin level in the high HOMA-IR group was significantly lower than that in the low HOMA-IR group. Our results suggest that platelet activation, adiponectin and oxidative stress are the very important factors for aging, and the maintenance of exercise could prevent the occurrence of metabolic syndrome or insulin resistance. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
C1 [Nomura, Shosaku] Kishiwada City Hosp, Div Hematol, Osaka 5968501, Japan.
   [Inami, Norihito; Inami, Osamu; Kimura, Yutaka; Iwasaka, Toshiji] Kansai Med Univ, Dept Internal Med 2, Osaka 5708507, Japan.
   [Urase, Fumiaki; Maeda, Yasuhiro] Kinki Univ, Sch Med, Dept Internal Med, Div Hematol, Osaka 5898511, Japan.
C3 Kansai Medical University; Kindai University (Kinki University)
RP Nomura, S (corresponding author), Kishiwada City Hosp, Div Hematol, 1001 Gakuhara Cho, Osaka 5968501, Japan.
EM shosaku-n@mbp.ocn.ne.jp
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NR 35
TC 4
Z9 5
U1 0
U2 0
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0167-4943
EI 1872-6976
J9 ARCH GERONTOL GERIAT
JI Arch. Gerontol. Geriatr.
PD JUL-AUG
PY 2009
VL 49
IS 1
BP 13
EP 16
DI 10.1016/j.archger.2008.04.004
PG 4
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA 455CF
UT WOS:000266733300003
PM 18468706
DA 2025-06-11
ER

PT J
AU Lee, DH
   Steffes, MW
   Jacobs, DR
AF Lee, D. -H.
   Steffes, M. W.
   Jacobs, D. R., Jr.
TI Can persistent organic pollutants explain the association between serum
   γ-glutamyltransferase and type 2 diabetes?
SO DIABETOLOGIA
LA English
DT Article
DE environmental pollutants; gamma-glutamyltransferase; obesity; persistent
   organic pollutants; type 2 diabetes
ID ARTERY RISK DEVELOPMENT; 3RD NATIONAL-HEALTH; CARDIOVASCULAR-DISEASE;
   GLUTATHIONE CONJUGATION; METABOLIC SYNDROME; OXIDATIVE-STRESS; DIOXIN;
   COHORT; GLUTAMYLTRANSFERASE; HYPERTENSION
AB The results of several epidemiological studies of serum gamma-glutamyltransferase (GGT) led us to hypothesise that associations of GGT within its normal range with type 2 diabetes may reflect detrimental effects of xenobiotics found in the environment, such as persistent organic pollutants (POPs). Epidemiological observations showed that serum GGT activity within its normal range strongly predicted future type 2 diabetes; the predictability of diabetes from obesity was low with GGT at the low end of the normal range; and GGT showed a positive association with known markers of oxidative stress or inflammation. Experimental findings on cellular GGT suggest that serum GGT levels within the normal range may reflect oxidative stress related to the re-synthesis of intracellular glutathione; however, this interpretation is not completely satisfying because, in its role of regenerating intracellular glutathione, GGT activity should be antioxidative. Alternatively, serum GGT activity may reflect amounts of glutathione conjugates formed during the metabolism of xenobiotics. Accordingly, we postulate a two-part hypothesis: that the association of serum GGT with type 2 diabetes reflects exposure to POPs, as these substances, which have a very long half-life, may influence diabetes risk by residing in adipose tissue as endocrine disruptors; and that POPs or similar substances may interact with obesity to cause type 2 diabetes. Supporting this hypothesis, cross-sectional investigation of background exposure to POPs in the National Health and Nutrition Examination Survey showed relationships similar to those observed for GGT, including a powerful association with prevalent diabetes and no association between obesity and diabetes for very low POP concentrations. Our hypothesis can be tested in both prospective studies and toxicological studies.
C1 [Lee, D. -H.] Kyungpook Natl Univ, Sch Med, Dept Prevent Med, Taegu 700422, South Korea.
   [Lee, D. -H.] Kyungpook Natl Univ, Sch Med, Hlth Promot Res Ctr, Taegu 700422, South Korea.
   [Steffes, M. W.] Univ Minnesota, Dept Lab Med & Pathol, Minneapolis, MN 55455 USA.
   [Jacobs, D. R., Jr.] Univ Minnesota, Sch Publ Hlth, Div Epidemiol, Minneapolis, MN 55455 USA.
   [Jacobs, D. R., Jr.] Univ Oslo, Dept Nutr, Oslo, Norway.
C3 Kyungpook National University (KNU); Kyungpook National University
   (KNU); University of Minnesota System; University of Minnesota Twin
   Cities; University of Minnesota System; University of Minnesota Twin
   Cities; University of Oslo
RP Lee, DH (corresponding author), Kyungpook Natl Univ, Sch Med, Dept Prevent Med, 101 Dongin Dong, Taegu 700422, South Korea.
EM lee_dh@knu.ac.kr
RI Jacobs, David/G-5405-2011
OI Jacobs, David/0000-0002-7232-0543
FU NHLBI NIH HHS [R01 HL053560] Funding Source: Medline
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NR 50
TC 59
Z9 60
U1 0
U2 8
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0012-186X
EI 1432-0428
J9 DIABETOLOGIA
JI Diabetologia
PD MAR
PY 2008
VL 51
IS 3
BP 402
EP 407
DI 10.1007/s00125-007-0896-5
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 258RW
UT WOS:000252888200005
PM 18071669
OA Bronze
DA 2025-06-11
ER

PT J
AU Hoogeveen, RC
   Ballantyne, CM
   Bang, H
   Heiss, G
   Duncan, BB
   Folsom, AR
   Pankow, JS
AF Hoogeveen, R. C.
   Ballantyne, C. M.
   Bang, H.
   Heiss, G.
   Duncan, B. B.
   Folsom, A. R.
   Pankow, J. S.
TI Circulating oxidised low-density lipoprotein and intercellular adhesion
   molecule-1 and risk of type 2 diabetes mellitus: the Atherosclerosis
   Risk in Communities Study
SO DIABETOLOGIA
LA English
DT Article
DE diabetes; ICAM-1; inflammation; oxidised LDL
ID IMPAIRED GLUCOSE-TOLERANCE; ENDOTHELIAL DYSFUNCTION;
   MYOCARDIAL-INFARCTION; METABOLIC SYNDROME; VASCULAR-DISEASE; LDL;
   INFLAMMATION; MARKERS; SUSCEPTIBILITY; HYPERGLYCEMIA
AB Aims/hypothesis To evaluate the role of oxidative stress and inflammation in the aetiology of type 2 diabetes, we examined the association of oxidised LDL (ox-LDL) and soluble intercellular adhesion molecule-1 (sICAM-1) levels with type 2 diabetes incidence over 9 years in the Atherosclerosis Risk in Communities Study.
   Materials and methods In a large, prospective, case-cohort design, ox-LDL and sICAM-1 were measured in stored plasma samples collected at baseline in stratified samples of 581 diabetes cases and 572 non-cases selected from 10,275 middle-aged men and women without prevalent diabetes at baseline.
   Results Compared with non-cases, diabetes cases had significantly higher mean baseline levels of ox-LDL and sICAM-1. Elevated ox-LDL and sICAM-1 were both associated with increased risk of incident diabetes after adjustment for age, sex, race and centre, with hazard ratios for the highest vs lowest tertiles of 1.68 (95% CI 1.25-2.24) and 1.91 (95% CI 1.45-2.50), respectively. After additional adjustment for fasting glucose, waist circumference, HDL-cholesterol, triacylglycerol, hypertension and C-reactive protein, only sICAM-1 remained an independent predictor of incident diabetes (hazard ratio 1.50; 95% CI 1.02-2.23).
   Conclusions/interpretation In this community-based cohort of middle-aged US adults, elevated plasma ox-LDL and sICAM-1 levels were associated with increased risk of type 2 diabetes. Measurement of ICAM-1 or ox-LDL, or other measures related to inflammation or oxidative stress, may be helpful in identifying those patient populations in which to test whether novel therapies that inhibit specific pathways related to inflammation or oxidative stress are beneficial in the prevention of diabetes in humans.
C1 Baylor Coll Med, Dept Med, Sect Atherosclerosis & Vasc Med, Houston, TX 77030 USA.
   Methodist DeBakey Heart Ctr, Ctr Cardiovasc Dis Prevent, Houston, TX USA.
   Cornell Univ, Div Biostat & Epidemiol, Dept Publ Hlth, Weill Med Coll, New York, NY USA.
   Univ N Carolina, Sch Publ Hlth, Dept Epidemiol, Chapel Hill, NC USA.
   Univ Fed Rio Grande do Sul, Sch Med, Grad Studies Program Epidemiol, Porto Alegre, RS, Brazil.
   Univ Minnesota, Sch Publ Hlth, Div Epidemiol & Community Hlth, Minneapolis, MN USA.
C3 Baylor College of Medicine; Houston Methodist; Cornell University; Weill
   Cornell Medicine; University of North Carolina; University of North
   Carolina Chapel Hill; Universidade Federal do Rio Grande do Sul;
   University of Minnesota System; University of Minnesota Twin Cities
RP Hoogeveen, RC (corresponding author), Baylor Coll Med, Dept Med, Sect Atherosclerosis & Vasc Med, Houston, TX 77030 USA.
EM ronh@bcm.tmc.edu
RI Ballantyne, Christie/A-6599-2008; Duncan, Bruce/L-4140-2016
OI Pankow, James/0000-0001-7076-483X; Duncan, Bruce/0000-0002-7491-2630;
   Ballantyne, Christie/0000-0002-6432-1730; Hoogeveen,
   Ron/0000-0003-2399-4653
FU NHLBI NIH HHS [N01-HC-55022, N01-HC-55020, N01-HC-55019, N01-HC-55015,
   N01-HC-55018, N01-HC-55016, N01-HC-55021] Funding Source: Medline; NIDDK
   NIH HHS [R01-DK56918] Funding Source: Medline
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NR 41
TC 42
Z9 49
U1 0
U2 5
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0012-186X
EI 1432-0428
J9 DIABETOLOGIA
JI Diabetologia
PD JAN
PY 2007
VL 50
IS 1
BP 36
EP 42
DI 10.1007/s00125-006-0533-8
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 121WP
UT WOS:000243188000007
PM 17136392
OA Bronze
DA 2025-06-11
ER

PT J
AU Obert, P
   Nottin, S
   Philouze, C
   Aboukhoudir, F
AF Obert, Philippe
   Nottin, Stephane
   Philouze, Clothilde
   Aboukhoudir, Falah
TI Major impact of vitamin D3 deficiency and supplementation on left
   ventricular torsional mechanics during dobutamine stress in
   uncomplicated type 2 diabetes
SO NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
LA English
DT Article
DE Uncomplicated type 2 diabetes; Dobutamine stress echocardiography;
   Speckle-tracking imaging; Regional myocardial function; Vitamin D3
ID EPICARDIAL ADIPOSE-TISSUE; SPECKLE-TRACKING ECHOCARDIOGRAPHY; CORONARY
   FLOW RESERVE; MYOCARDIAL DYSFUNCTION; EUROPEAN ASSOCIATION; METABOLIC
   SYNDROME; AMERICAN SOCIETY; FAT THICKNESS; MELLITUS; DISEASE
AB Background and aims: Hypovitaminosis D is associated with the risk of diabetic complications. Its role in diabetic-related cardiac abnormalities remain poorly understood. We aimed therefore to evaluate the effect of vitamin D deficiency and supplementation on early left ventricular (LV) dysfunction in vitamin D deficient patients with uncomplicated T2D.Methods and results: Sixty-three consecutive T2D patients who had a diagnosis of vitamin D-3 were prospectively recruited and allocated into 2 groups (25(OH)D < 20 ng/mL: VDD, >20 ng/mL VDND). Twenty-eight of them with 25(OH)D < 20 ng/mL benefited from a 3-month supplementation. At baseline and follow-up, after conventional echocardiography including evaluation of epicardial adipose tissue (EAT), both LV longitudinal (LS) and circumferential (CS) strains and rotation/twist mechanics were evaluated at rest and during dobutamine (DOB) stress. After treatment, T2D patients successfully normalized their 25(OH)D levels. The strongest associations between vitamin D deficiency and supplementation with LV myocardial function were noticed for torsional mechanics indexes under DOB. EAT correlated significantly (p < 0.01) with baseline 25(OH)D and was reduced after supplementation. Significant correlations were obtained between these 2 parameters with twist or apical rotation at baseline (p < 0.01) and between their delta changes at follow-up (p < 0.01) under DOB. Significant improvements in LS and CS (p < 0.05) under DOB were also underlined at follow-up, with major enhancements noticed in the apical region (p < 0.01) of the LV.Conclusions: This study provides the first evidences of the potential of vitamin D supplementation as an efficient prophylactic strategy to alleviate the progression of myocardial dysfunction in asymptomatic patients with uncomplicated T2D.
C1 [Obert, Philippe; Philouze, Clothilde; Aboukhoudir, Falah] Avignon Univ, Lab Expt Cardiovasc Physiol, UPR 4278 LaPEC, Avignon, France.
   [Aboukhoudir, Falah] Duffaut Hosp Ctr, Cardiol Dept, Avignon, France.
   [Obert, Philippe; Aboukhoudir, Falah] Univ Avignon, Fac Sci, 301 Rue Baruch de Spinoza, F-84916 Avignon 9, France.
C3 Avignon Universite; Avignon Universite
RP Obert, P; Aboukhoudir, F (corresponding author), Univ Avignon, Fac Sci, 301 Rue Baruch de Spinoza, F-84916 Avignon 9, France.
EM philippe.obert@univ-avignon.fr; faboukhoudir@ch-avignon.fr
OI Philouze, Clothilde/0000-0002-0669-0263; Nottin,
   Stephane/0000-0001-7797-1137; obert, philippe/0000-0003-0472-6338
FU French Society of Cardiology
FX <B>Sources of funding</B> This study was funded by a grant from the
   French Society of Cardiology.
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NR 57
TC 1
Z9 1
U1 0
U2 0
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 0939-4753
EI 1590-3729
J9 NUTR METAB CARDIOVAS
JI Nutr. Metab. Carbiovasc. Dis.
PD NOV
PY 2023
VL 33
IS 11
BP 2269
EP 2279
DI 10.1016/j.numecd.2023.06.017
EA OCT 2023
PG 11
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism; Nutrition
   & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism;
   Nutrition & Dietetics
GA Y7LO9
UT WOS:001107042200001
PM 37543521
OA Bronze
DA 2025-06-11
ER

PT J
AU Feairheller, DL
   Smith, M
   Carty, M
   Reeve, EH
AF Feairheller, Deborah L.
   Smith, Macie
   Carty, Megan
   Reeve, Emily H.
TI Blood pressure surge with alarm is reduced after exercise and diet
   intervention in firefighters
SO BLOOD PRESSURE MONITORING
LA English
DT Article
DE ambulatory blood pressure; blood pressure surge; cardiovascular disease;
   firefighters; Mediterranean diet; tactical
ID OXIDATIVE STRESS; RISK-FACTORS; ULTRASOUND ASSESSMENT; METABOLIC
   SYNDROME; DISEASE; RESPONSES; VALIDITY; CORONARY; ARTERY
AB BackgroundCardiac-related incidents are a public health concern for tactical occupations, and cardiovascular disease rates are higher in these populations compared with civilians. Research is needed to examine blood pressure (BP) responses in firefighters. The pager alert is one occupational hazard, and it is unknown if lifestyle change can reduce the systolic surge response. PurposeTo measure BP surge with alarm in firefighters to determine whether the magnitude is lower after a 6-week tactical exercise and Mediterranean-diet intervention. MethodsSBP and DBP and BP surge levels, circulating markers, vascular health, and fitness were analyzed. BP surge with alarm was captured during a 12-hour workshift. Exercise and diet were self-reported. Diet was tracked with diet scores based on number of servings. ResultsTwenty five firefighters (43.4 +/- 13.9 years) participated. We found changes in the magnitude of BP surge with alarm (SBP surge from16.7 +/- 12.9 to 10.5 +/- 11.7 mmHg, P < 0.05; DBP surge from 8.2 +/- 10.8 to 4.9 +/- 5.6 mmHg, P > 0.05) after intervention. We confirm that clinical (127.6 +/- 9.1 to 120 +/- 8.2 mmHg) and central (122.7 +/- 11.3 to 118.2 +/- 10.7 mmHg) SBP levels improve with exercise and diet. We report for the first time in firefighters that oxidative stress markers superoxide dismutase (9.1 +/- 1.5 to 11.2 +/- 2.2 U/ml) and nitric oxide (40.4 +/- 7 to 48.9 +/- 16.9 mu mol/l) levels improve with an exercise and diet intervention. ConclusionThese findings have implications toward the benefit that short-term lifestyle changes make toward reducing the alarm stress response in first responders.
C1 [Feairheller, Deborah L.; Smith, Macie] Calif State Univ San Marcos, Dept Kinesiol, San Marcos, CA USA.
   [Carty, Megan] Thomas Jefferson Univ, Jefferson Coll Populat Hlth, Philadelphia, PA USA.
   [Reeve, Emily H.] Univ Oregon, Dept Human Physiol, Eugene, OR USA.
   [Feairheller, Deborah L.] Calif State Univ San Marcos, Dept Kinesiol, 333 S Twin Oaks Valley Rd, San Marcos, CA 92096 USA.
C3 California State University System; California State University San
   Marcos; Thomas Jefferson University; University of Oregon; California
   State University System; California State University San Marcos
RP Feairheller, DL (corresponding author), Calif State Univ San Marcos, Dept Kinesiol, 333 S Twin Oaks Valley Rd, San Marcos, CA 92096 USA.
EM dfeairheller@csusm.edu
FU American Heart Association [19AIREA34450151]; American Heart Association
   (AHA) [19AIREA34450151] Funding Source: American Heart Association (AHA)
FX The authors would like to thank the firefighters for participating in
   our study. The authors would also like to thank the HEART lab student
   researchers who helped with data collection. This work was supported by
   the American Heart Association Grant 19AIREA34450151 (D.L.F.).
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NR 48
TC 1
Z9 1
U1 0
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1359-5237
EI 1473-5725
J9 BLOOD PRESS MONIT
JI Blood Press. Monit.
PD JUN
PY 2023
VL 28
IS 3
BP 134
EP 143
DI 10.1097/MBP.0000000000000649
PG 10
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA F5OJ0
UT WOS:000982835100003
PM 37070561
OA Green Published, hybrid
DA 2025-06-11
ER

EF﻿FN Clarivate Analytics Web of Science
VR 1.0
PT J
AU Barghi, M
   Ranjbar, AS
   Moazen, H
   Eskandari-Roozbahani, N
AF Barghi, Maryam
   Ranjbar, Amir Sadeghipoor
   Moazen, Homa
   Eskandari-Roozbahani, Narges
TI Serum levels of vitamin D, calcium, phosphorus, and oxidative parameters
   in healthy and diabetic people
SO FUNCTIONAL FOODS IN HEALTH AND DISEASE
LA English
DT Article
DE Vitamin D; Diabetes mellitus; HPLC; Oxidative stress
ID D SUPPLEMENTATION; METABOLIC SYNDROME; MELLITUS; STRESS; RISK; BONE
AB Introduction: Diabetes mellitus is a metabolic disease that is a primary public health consideration. Low Vitamin D levels are linked to type 2 diabetes (T2DM), diminished insulin release, and enhanced insulin resistance in humans and animals. Vitamin D is also involved in the regulation of calcium and phosphorus homeostasis. Oxidative stress and antioxidant imbalances are important for the progression of diabetes as well. In this endeavor, the levels of vitamin D, calcium, phosphorus, and evaluation of the oxidant-antioxidant factors of malondialdehyde (MDA) and total antioxidant capacity (TAC) in healthy and diabetic people were compared.
   Methods: This descriptive-analytical study was conducted in 2020 in Shiraz, Fars province, Iran. The population included 40 T2DM patients (with HbA1c equivalent 6-8) without comorbidities, 20-60 years old for both genders, and 40 healthy individuals (female and male between 20-60 years old without comorbidities). The high-performance liquid chromatography (HPLC) method was adopted for measuring Vitamin D and for measuring other levels, the colorimetric method was used. Using SPSS 22, statistical analysis was performed. The Mann-Whitney U test for quantitative data was applied. P<0.05 was deemed significant.
   Results: There was a statistically significant difference between the two groups when it came to the means of vitamin D and MDA. In the diabetic group, vitamin D levels were lower (p=0.001) and MDA levels were higher (p<0.001). Comparing the level of calcium and phosphorus in diabetics and healthy people revealed no significant difference. This result was also true for the TAC test.
   Conclusions: According to our results, the mean of vitamin D in T2DM was significantly lower than healthy people and MDA in T2DM significantly increased compared to the control group, suggesting that increasing the activity of this enzyme in the development of secondary complications in diabetic patients is a predisposing factor.
C1 [Barghi, Maryam] Shiraz Univ, Fac Vet Med, Dept Biochem, Shiraz, Iran.
   [Ranjbar, Amir Sadeghipoor] Islamic Azad Univ, Fac Engn, Dept Microbiol, Sirjan Branch, Kerman, Iran.
   [Moazen, Homa] Shahid Sadoughi Univ Med Sci, Dept Biostat & Epidemiol, Yazd, Iran.
   [Eskandari-Roozbahani, Narges] Kermanshah Univ Med Sci, Imam Reza Hosp, Clin Res Dev Ctr, Kermanshah, Iran.
C3 Shiraz University; Islamic Azad University; Shahid Sadoughi University
   of Medical Sciences; Kermanshah University of Medical Sciences
RP Eskandari-Roozbahani, N (corresponding author), Kermanshah Univ Med Sci, Imam Reza Hosp, Clin Res Dev Ctr, Kermanshah, Iran.
RI Eskandari-Roozbahani, Narges/AFJ-4946-2022
OI Eskandari Roozbahani, Narges/0000-0003-2509-9177
CR Alvarez JA, 2010, INT J ENDOCRINOL, V2010, DOI 10.1155/2010/351385
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NR 30
TC 1
Z9 1
U1 0
U2 0
PU FUNCTIONAL FOOD CENTER INC
PI DALLAS
PA 5050 QUORUM DR, STE 700,  NO 338, DALLAS, TX 75254 USA
SN 2160-3855
J9 FUNCT FOODS HEALTH D
JI Funct. Foods Health Dis.
PD MAY
PY 2021
VL 11
IS 5
BP 238
EP 245
DI 10.31989/ffhd.v11i5.787
PG 8
WC Food Science & Technology
WE Emerging Sources Citation Index (ESCI)
SC Food Science & Technology
GA SE7DX
UT WOS:000652231900003
OA gold
DA 2025-06-11
ER

PT J
AU Wang, Y
   Wang, GZ
   Rabinovitch, PS
   Tabas, I
AF Wang, Ying
   Wang, Gary Z.
   Rabinovitch, Peter S.
   Tabas, Ira
TI Macrophage Mitochondrial Oxidative Stress Promotes Atherosclerosis and
   Nuclear Factor-κB-Mediated Inflammation in Macrophages
SO CIRCULATION RESEARCH
LA English
DT Article
DE atherosclerosis; macrophages; NF-kappa B; reactive oxygen species
ID LOW-DENSITY-LIPOPROTEIN; MONOCYTE CHEMOATTRACTANT PROTEIN-1;
   ENDOPLASMIC-RETICULUM STRESS; PLASMACYTOID DENDRITIC CELLS;
   RECEPTOR-DEFICIENT MICE; APOE(-/-) MICE; DNA-DAMAGE; METABOLIC SYNDROME;
   PLAQUES; ACTIVATION
AB Rationale: Mitochondrial oxidative stress (mitoOS) has been shown to correlate with the progression of human atherosclerosis. However, definitive cell type-specific causation studies in vivo are lacking, and the molecular mechanisms of potential proatherogenic effects remain to be determined.
   Objective: Our aims were to assess the importance of macrophage mitoOS in atherogenesis and to explore the underlying molecular mechanisms.
   Methods and Results: We first validated Western diet-fed Ldlr(-/-) mice as a model of human mitoOS-atherosclerosis association by showing that non-nuclear oxidative DNA damage, a marker of mitoOS in lesional macrophages, correlates with aortic root lesion development. To investigate the importance of macrophage mitoOS, we used a genetic engineering strategy in which the OS suppressor catalase was ectopically expressed in mitochondria (mCAT) in macrophages. MitoOS in lesional macrophages was successfully suppressed in these mice, and this led to a significant reduction in aortic root lesional area. The mCAT lesions had less monocyte-derived cells, less Ly6c(hi) monocyte infiltration into lesions, and lower levels of monocyte chemotactic protein-1. The decrease in lesional monocyte chemotactic protein-1 was associated with the suppression of other markers of inflammation and with decreased phosphorylation of RelA (NF-B p65), indicating decreased activation of the proinflammatory NF-B pathway. Using models of mitoOS in cultured macrophages, we showed that mCAT suppressed monocyte chemotactic protein-1 expression by decreasing the activation of the IB-kinase -RelA NF-B pathway.
   Conclusions: MitoOS in lesional macrophages amplifies atherosclerotic lesion development by promoting NF-B-mediated entry of monocytes and other inflammatory processes. In view of the mitoOS-atherosclerosis link in human atheromata, these findings reveal a potentially new therapeutic target to prevent the progression of atherosclerosis.
C1 [Wang, Ying; Tabas, Ira] Columbia Univ, Dept Med Physiol & Cellular Biophys, New York, NY 10032 USA.
   [Wang, Ying; Tabas, Ira] Columbia Univ, Dept Pathol & Cell Biol, New York, NY 10032 USA.
   [Wang, Gary Z.] Columbia Univ, Med Scientist Training Program, New York, NY 10032 USA.
   [Rabinovitch, Peter S.] Univ Washington, Dept Pathol, Seattle, WA 98195 USA.
C3 Columbia University; Columbia University; Columbia University;
   University of Washington; University of Washington Seattle
RP Tabas, I (corresponding author), Columbia Univ, Med Ctr, Dept Med, 630 W 168th St, New York, NY 10032 USA.
EM iat1@columbia.edu
RI Wang, Ying/J-1479-2014
OI Tabas, Ira/0000-0003-3429-1515
FU American Heart Association; National Institutes of Health [PO1AG001751,
   RO1HL101186, P30AG13280, R01HL075662, R01HL106019]
FX This study was supported by an American Heart Association predoctoral
   training grant to Y.W., and by National Institutes of Health grants to
   P. S. R. (PO1AG001751, RO1HL101186, P30AG13280) and I. T. (R01HL075662,
   R01HL106019).
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NR 61
TC 213
Z9 229
U1 1
U2 21
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0009-7330
EI 1524-4571
J9 CIRC RES
JI Circ.Res.
PD JAN 31
PY 2014
VL 114
IS 3
BP 421
EP 433
DI 10.1161/CIRCRESAHA.114.302153
PG 13
WC Cardiac & Cardiovascular Systems; Hematology; Peripheral Vascular
   Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Hematology
GA AG7GR
UT WOS:000335586800007
PM 24297735
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Marta, M
   Zanchetti, A
   Wong, ND
   Malyszko, J
   Rysz, J
   Banach, M
AF Marta, Michalska
   Zanchetti, Alberto
   Wong, Nathan D.
   Malyszko, Jolanta
   Rysz, Jacek
   Banach, Maciej
TI Patients with Prehypertension - Do we have Enough Evidence to Treat
   them?
SO CURRENT VASCULAR PHARMACOLOGY
LA English
DT Article
DE Blood pressure; cardiovascular risk; high normal blood pressure;
   hypertension; prehypertension; risk stratification
ID EXPERT CONSENSUS DOCUMENT; NORMAL BLOOD-PRESSURE; CARDIOVASCULAR-DISEASE
   RISK; CONVERTING-ENZYME-INHIBITOR; JOINT NATIONAL COMMITTEE; TYPE-2
   DIABETIC-PATIENTS; LIFE-STYLE MODIFICATION; METABOLIC SYNDROME; ARTERIAL
   STIFFNESS; HEART-DISEASE
AB In 2003, the Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure established a definition of a new category of BP levels called 'prehypertension' (preHT) that included individuals with a systolic BP of 120-139 mm Hg or a diastolic BP of 80-89 mm Hg. Patients with preHT were considered to be at increased risk for progression to hypertension and in individuals with BP in the range 130/80 to 139/89 mmHg the risk of developing hypertension was twice as high as in subjects with lower values. Still then there has been a large debate whether the introduction of preHT was based on evidence and as a consequence, it was fully justified. It has been suggested that the term prehypertension may in many subjects create anxiety and a need for unnecessary medical visits and examinations. This group of patients is also very heterogeneous and it has been pointed out that subdividing preHT group into individuals with normal BP and high normal BP would much better correspond to the continuum of BP risk for CV disease. Finally, despite some data suggesting the potential benefits of antihypertensive therapy in patients with preHT (high normal BP), there are still no hard evidences on the outcome reduction by giving antihypertensive drugs in these individuals.
C1 [Marta, Michalska; Rysz, Jacek; Banach, Maciej] Med Univ Lodz, Dept Hypertens, PL-90549 Lodz, Poland.
   [Zanchetti, Alberto] Univ Milan, Ist Auxol Italiano, Milan, Italy.
   [Wong, Nathan D.] Univ CA, Dept Med, Irvine, CA USA.
   [Malyszko, Jolanta] Med Univ, Dept Nephrol & Transplantol, Bialystok, Poland.
C3 Medical University Lodz; University of Milan; IRCCS Istituto Auxologico
   Italiano; Medical University of Bialystok
RP Banach, M (corresponding author), Med Univ Lodz, WAM Univ Hosp Lodz, Dept Hypertens, Zeromskiego 113, PL-90549 Lodz, Poland.
EM maciejbanach@aol.co.uk
RI Malyszko, Jolanta/GSM-7177-2022; Malyszko, Jolanta/M-7295-2018; Rysz,
   Jacek/L-8313-2013; Banach, Maciej/A-1271-2009
OI Malyszko, Jolanta/0000-0001-8701-8171; zanchetti,
   alberto/0000-0003-4796-7959; Rysz, Jacek/0000-0002-2757-6443; Banach,
   Maciej/0000-0001-6690-6874
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NR 129
TC 3
Z9 3
U1 0
U2 5
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1570-1611
EI 1875-6212
J9 CURR VASC PHARMACOL
JI Current Vascular Pharmacology
PY 2014
VL 12
IS 4
BP 586
EP 597
DI 10.2174/15701611113119990126
PG 12
WC Pharmacology & Pharmacy; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Cardiovascular System & Cardiology
GA AW4US
UT WOS:000346276400005
PM 23627984
DA 2025-06-11
ER

PT J
AU Bharti, V
   Bhardwaj, A
   Elias, DA
   Metcalfe, AWS
   Kim, JS
AF Bharti, Veni
   Bhardwaj, Aseem
   Elias, David A.
   Metcalfe, Arron W. S.
   Kim, Jong Sung
TI A Systematic Review and Meta-Analysis of Lipid Signatures in
   Post-traumatic Stress Disorder
SO FRONTIERS IN PSYCHIATRY
LA English
DT Review
DE post-traumatic stress disorder; psychiatric disorders; major depressive
   disorder; lipids; fatty acids
ID CORONARY-HEART-DISEASE; DENSITY-LIPOPROTEIN CHOLESTEROL; METABOLIC
   SYNDROME; SERUM-CHOLESTEROL; NERVOUS-SYSTEM; WHITE-MATTER; RISK-FACTORS;
   TRIGLYCERIDE; VETERANS; CORTISOL
AB Background: Research assessing lipid levels in individuals diagnosed with post-traumatic stress disorder (PTSD) has yielded mixed results. This study aimed to employ meta-analytic techniques to characterize the relationship between the levels of lipid profiles and PTSD. Methods: We performed meta-analyses of studies comparing profiles and levels of lipids between PTSD patients and healthy individuals by searching Embase, Ovid Medline, Scopus, PsycINFO, and Cochrane databases for the studies until March 2021. Meta-analyses were performed using random-effects models with the restricted maximum-likelihood estimator to synthesize the effect size assessed by standardized mean difference (SMD) across studies. Findings: A total of 8,657 abstracts were identified, and 17 studies were included. Levels of total cholesterol (TC) (SMD = 0.57 95% CI, 0.27-0.87, p = 0.003), low-density lipoprotein (LDL) (SMD = 0.48, 95% CI, 0.19-0.76, p = 0.004), and triglyceride (TG) (SMD = 0.46, 95% CI, 0.22-0.70, p = 0.001) were found to be higher, while levels of high-density lipoprotein (HDL) (SMD = -0.47, -0.88 to -0.07, p = 0.026) were found to be lower in PTSD patients compared to healthy controls. Subgroup analysis showed that TG levels were higher in PTSD patients who were on or off of psychotropic medications, both < 40 and >= 40 years of age, and having body mass index of < 30 and >= 30 compared to healthy controls. Interpretation: This work suggested dysregulation of lipids in PTSD that may serve as biomarker to predict the risk. The study will be useful for physicians considering lipid profiles in PTSD patients to reduce cardiovascular morbidity and mortality.
C1 [Bharti, Veni; Kim, Jong Sung] Dalhousie Univ, Fac Med, Dept Community Hlth & Epidemiol, Halifax, NS B3H 4R2, Canada.
   [Bharti, Veni; Bhardwaj, Aseem; Kim, Jong Sung] Dalhousie Univ, Fac Med, Hlth & Environm Res Ctr HERC Lab, Halifax, NS B3H 1V7, Canada.
   [Elias, David A.; Metcalfe, Arron W. S.] Canadian Hlth Solut Inc, Saint John, NB, Canada.
   [Elias, David A.] Dalhousie Univ, Dalhousie Med New Brunswick, Halifax, NS, Canada.
   [Metcalfe, Arron W. S.] Canadian Imaging Res Ctr, Saint John, NB, Canada.
C3 Dalhousie University; Dalhousie University; Dalhousie University
RP Kim, JS (corresponding author), Dalhousie Univ, Fac Med, Dept Community Hlth & Epidemiol, Halifax, NS B3H 4R2, Canada.; Kim, JS (corresponding author), Dalhousie Univ, Fac Med, Hlth & Environm Res Ctr HERC Lab, Halifax, NS B3H 1V7, Canada.
EM jskim@dal.ca
RI Metcalfe, Arron/A-5806-2008
OI Metcalfe, Arron/0000-0002-8036-866X
FU Mitacs Accelerate Postdoctoral Fellowship; National Research Council of
   Canada Industrial Research Assistance Program (NRC-IRAP)-Canadian
   International Innovation Program (CIIP); Scientific Research and
   Experimental Development (SR&ED) Tax Incentive Program from the
   Government of Canada
FX This research was conducted with funding from the Mitacs Accelerate
   Postdoctoral Fellowship, investment from the National Research Council
   of Canada Industrial Research Assistance Program (NRC-IRAP)-Canadian
   International Innovation Program (CIIP), and the Scientific Research and
   Experimental Development (SR&ED) Tax Incentive Program from the
   Government of Canada.
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NR 95
TC 10
Z9 10
U1 0
U2 6
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-0640
J9 FRONT PSYCHIATRY
JI Front. Psychiatry
PD MAY 6
PY 2022
VL 13
AR 847310
DI 10.3389/fpsyt.2022.847310
PG 12
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 1K8DX
UT WOS:000798827700001
PM 35599759
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Ferri, J
   Navarro, I
   Alabadí, B
   Bosch-Sierra, N
   Benito, E
   Civera, M
   Ascaso, JF
   Martinez-Hervas, S
   Real, JT
AF Ferri, Jordi
   Navarro, Inmaculada
   Alabadi, Blanca
   Bosch-Sierra, Neus
   Benito, Esther
   Civera, Miguel
   Ascaso, Juan F.
   Martinez-Hervas, Sergio
   Real, Jose T.
TI Gender differences on oxidative stress markers and complement component
   C3 plasma values after an oral unsaturated fat load test
SO CLINICA E INVESTIGACION EN ARTERIOSCLEROSIS
LA English
DT Article
DE Complement component C3; Oxidative stress; Post-prandial; "paernia; Oral
   fat load tes; Unsaturated fat
ID POSTPRANDIAL LIPEMIA; ENDOTHELIAL FUNCTION; METABOLIC SYNDROME; OLIVE
   OIL; SEX; MODULATION
AB Objective: Post-prandial lipaemia (PL), oxidative stress (OS), and complement component C3 (C3) values are related to the atherosclerosis process. The post-prandial response of C3 after an oral fat toad test (OFLT) using unsaturated fat is poorly addressed. The aim of this study was to analyze and compare the post-prandial response of OS markers and C3 values in men and women after an OFLT using unsaturated fat. Methods: The study included a total of 22 healthy subjects with normal lipids and normal blood glucose (11 men and 11 pre-menopausal women). An oral unsaturated fat toad test (OFLT: 50g fat per m2 body surface) was performed using a commercial liquid preparation of tong chain triglycerides (SupracaL). OS markers and C3 were measured using standardized methods at fasting state and every 2 h up to 8 h after the OFLT. Results: Men showed statistically significant higher C3, oxidized glutathione (GSSG), and oxidized-reduced glutathione (GSSG/GSH) ratio values at fasting state compared to that obtained in women. In addition, post-prandial C3 values and GSSG/GSH ratios were significantly higher in men compared to women. The GSSG value and GSSG/GSH ratio significantly decreased in men after the OFLT compared to fasting values. In contrast, the post-prandial OS markers decrease observed in women was not statistically significant. Conclusions: In fasting state, men showed higher statistically significant C3 values and OS markers than women. The post -prandial OS markers (0550 and GSSG/GSH ratio) significantly decrease after the OFLT with unsaturated fat in men compared to women. 2019 Sociedad Espanola de Arteriosclerosis. Published by Elsevier Espana, S.L.U. All rights reserved.
C1 [Ferri, Jordi; Navarro, Inmaculada; Alabadi, Blanca; Bosch-Sierra, Neus; Benito, Esther; Civera, Miguel; Ascaso, Juan F.; Martinez-Hervas, Sergio; Real, Jose T.] Hosp Clin Univ Valencia, Serv Endocrinol & Nutr, Valencia, Spain.
   [Ferri, Jordi; Alabadi, Blanca; Benito, Esther; Civera, Miguel; Ascaso, Juan F.; Martinez-Hervas, Sergio; Real, Jose T.] Hosp Clin Univ Valencia INCLIVA, Inst Hlth Res, Valencia, Spain.
   [Ferri, Jordi; Civera, Miguel; Ascaso, Juan F.; Martinez-Hervas, Sergio; Real, Jose T.] Univ Valencia, Dept Med, Valencia, Spain.
   [Benito, Esther; Martinez-Hervas, Sergio; Real, Jose T.] CIBER Diabet & Enfermedades Metab Asociadas CIBER, Madrid, Spain.
C3 Hospital Clinic Universitari de Valencia; University of Valencia; CIBER
   - Centro de Investigacion Biomedica en Red; CIBERES
RP Martinez-Hervas, S (corresponding author), Hosp Clin Univ Valencia, Serv Endocrinol & Nutr, Valencia, Spain.; Martinez-Hervas, S (corresponding author), Hosp Clin Univ Valencia INCLIVA, Inst Hlth Res, Valencia, Spain.; Martinez-Hervas, S (corresponding author), Univ Valencia, Dept Med, Valencia, Spain.; Martinez-Hervas, S (corresponding author), CIBER Diabet & Enfermedades Metab Asociadas CIBER, Madrid, Spain.
EM sergio.martinez@uv.es
RI ; Martinez Hervas, Sergio/K-2829-2014
OI Alabadi, Blanca/0000-0001-5129-6954; Martinez Hervas,
   Sergio/0000-0002-6775-2034; Bosch, Neus/0000-0002-7582-4085
FU Carlos III Health Institute [PI15/00082, JR18/00051]; Spanish Ministry
   of Health; Spanish Ministry of Economy and Competiveness; European
   Regional Development Fund (FEDER)
FX We acknowledge financial support by grants PI15/00082, from the Carlos
   III Health Institute, the Spanish Ministry of Health, the Spanish
   Ministry of Economy and Competiveness, and the European Regional
   Development Fund (FEDER). Sergio Martinez Hervas is an investigator from
   the 'JuanRodes' programme (JR18/00051) financed by the Carlos III Health
   Institute and the European Regional Development Fund (FEDER).
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NR 25
TC 4
Z9 4
U1 0
U2 2
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0214-9168
EI 1578-1879
J9 CLIN INVEST ARTERIOS
JI Clin. Invest. Arterioscler.
PD MAY-JUN
PY 2020
VL 32
IS 3
BP 87
EP 93
DI 10.1016/j.arteri.2019.11.002
PG 7
WC Peripheral Vascular Disease
WE Emerging Sources Citation Index (ESCI)
SC Cardiovascular System & Cardiology
GA LX7OJ
UT WOS:000540016400002
PM 32291193
DA 2025-06-11
ER

PT J
AU Pausova, Z
   Mahboubi, A
   Abrahamowicz, M
   Leonard, GT
   Perron, M
   Richer, L
   Veillette, S
   Gaudet, D
   Paus, T
AF Pausova, Zdenka
   Mahboubi, Amel
   Abrahamowicz, Michal
   Leonard, Gabriel T.
   Perron, Michel
   Richer, Louis
   Veillette, Suzanne
   Gaudet, Daniel
   Paus, Tomas
TI Sex Differences in the Contributions of Visceral and Total Body Fat to
   Blood Pressure in Adolescence
SO HYPERTENSION
LA English
DT Article
DE abdominal obesity; blood pressure; adolescence; sex differences and
   mental stress
ID SUBCUTANEOUS ADIPOSE-TISSUE; CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME;
   RISK-FACTORS; US CHILDREN; HYPERTENSION; PREVALENCE; GENDER; OVERWEIGHT;
   OBESITY
AB Excess body fat deposited viscerally rather than elsewhere in the body is associated with higher risk for hypertension; this relationship is stronger in men than in women. Here we investigated whether similar sex dimorphism exists already in adolescence. A population-based sample of adolescent boys (n = 237) and girls (n = 262), age 12 to 18 years, was studied. Total body fat (TBF) was assessed with multifrequency bioelectrical impedance, and visceral fat (VF) was quantified with MRI. Blood pressure (BP) was measured beat by beat during an hour-long protocol, including supine, standing, sitting, mental stress, and poststress sections. Multivariate mixed-model analysis was used to assess the relative contributions of TBF and VF to BP during these sections. In boys, BP was strongly positively associated with VF (P<.0001), whereas it was less strongly and negatively associated with TBF (P=.004); these relationships did not substantially vary during the protocol. In contrast, in girls, BP was strongly positively associated with TBF (P=0.0006), whereas it was not associated with VF (P=0.08); the relationship with TBF varied during the protocol and was most apparent during mental stress (TBF*section interaction: P=0.002). Furthermore, when waist circumference was included in multivariate models instead of VF, it was not associated with BP in either sex; this indicates that waist circumference may not be an appropriate surrogate for VF. Thus, in adolescence, adiposity-related BP elevation is driven mainly by visceral fat in males and by fat deposited elsewhere in females. This dimorphism suggests sex-specific mechanisms of obesity-induced hypertension and the need for sex-specific criteria of its prevention. (Hypertension. 2012; 59: 572-579.). Online Data Supplement
C1 [Pausova, Zdenka] Univ Toronto, Hosp Sick Children, Toronto, ON M5G 1X8, Canada.
   [Mahboubi, Amel; Abrahamowicz, Michal; Leonard, Gabriel T.; Paus, Tomas] McGill Univ, Montreal Neurol Inst, Montreal, PQ, Canada.
   [Perron, Michel; Richer, Louis] Univ Quebec Chicoutimi, Chicoutimi, PQ, Canada.
   [Veillette, Suzanne] Groupe ECOBES, Jonquiere, PQ, Canada.
   [Gaudet, Daniel] Univ Montreal, Chicoutimi Hosp, Community Genom Ctr, Chicoutimi, PQ, Canada.
   [Paus, Tomas] Rotman Res Inst, Toronto, ON, Canada.
C3 University of Toronto; Hospital for Sick Children (SickKids); McGill
   University; University of Quebec; University of Quebec Chicoutimi;
   Universite de Montreal; University of Toronto; Baycrest
RP Pausova, Z (corresponding author), Univ Toronto, Hosp Sick Children, 555 Univ Ave, Toronto, ON M5G 1X8, Canada.
EM zdenka.pausova@sickkids.ca
RI Poustka, Luise/D-9299-2017
OI Abrahamowicz, Michal/0000-0002-3172-3952
FU Canadian Institutes of Health Research; Heart and Stroke Foundation of
   Quebec; Canadian Foundation for Innovation
FX The Canadian Institutes of Health Research (Z.P., T. P.), Heart and
   Stroke Foundation of Quebec (Z.P.), and the Canadian Foundation for
   Innovation (Z.P.) fund the Saguenay Youth Study. M. A. is a James McGill
   Professor of Biostatistics at McGill University.
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NR 54
TC 46
Z9 50
U1 0
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0194-911X
EI 1524-4563
J9 HYPERTENSION
JI Hypertension
PD MAR
PY 2012
VL 59
IS 3
BP 572
EP U113
DI 10.1161/HYPERTENSIONAHA.111.180372
PG 16
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 911KF
UT WOS:000301715000019
PM 22291448
DA 2025-06-11
ER

PT J
AU Norris, AL
   Steinberger, J
   Steffen, LM
   Metzig, AM
   Schwarzenberg, SJ
   Kelly, AS
AF Norris, Anne L.
   Steinberger, Julia
   Steffen, Lyn M.
   Metzig, Andrea M.
   Schwarzenberg, Sarah Jane
   Kelly, Aaron S.
TI Circulating Oxidized LDL and Inflammation in Extreme Pediatric Obesity
SO OBESITY
LA English
DT Article
ID LOW-DENSITY-LIPOPROTEIN; C-REACTIVE PROTEIN; CARDIOVASCULAR
   RISK-FACTORS; BODY-MASS-INDEX; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   OXIDATIVE STRESS; DIABETES-MELLITUS; CHILDREN; DISEASE
AB Oxidative stress and inflammation have not been well-characterized in extreme pediatric obesity. We compared levels of circulating oxidized low-density lipoprotein (oxLDL), C-reactive protein (CRP), and interleukin-6 (IL-6) in extremely obese (EO) children to normal weight (NW) and overweight/obese (OW/OB) children. OxLDL, CRP, IL-6, BMI, blood pressure, and fasting glucose, insulin, and lipids were obtained in 225 children and adolescents (age 13.5 +/- 2.5 years; boys 55%). Participants were classified into three groups based on gender-and age-specific BMI percentile: NW (<85th, n = 127), OW/OB (85th-<1.2 times the 95th percentile, n = 64) and EO (>= 1.2 times the 95th percentile or BMI >= 35kg/m(2), n = 34). Measures were compared across groups using analysis of covariance, adjusted for gender, age, and race. Blood pressure, insulin, and lipids worsened across BMI groups (all P < 0.0001). OxLDL (NW: 40.8 +/- 9.0 U/l, OW/OB: 45.7 +/- 12.1 U/l, EO: 63.5 +/- 13.8 U/l) and CRP (NW: 0.5 +/- 1.0 mg/l, OW/OB: 1.4 +/- 2.9 mg/l, EO: 5.6 +/- 4.9 mg/l) increased significantly across BMI groups (all groups differed with P < 0.01). IL-6 was significantly higher in EO (2.0 +/- 0.9 pg/ml) compared to OW/OB (1.3 +/- 1.2 pg/ml, P < 0.001) and NW (1.1 +/- 1.0 pg/ml, P < 0.0001) but was not different between NW and OW/OB. Extreme pediatric obesity, compared to milder forms of adiposity and NW, is associated with higher levels of oxidative stress and inflammation, suggesting that markers of early cardiovascular disease and type 2 diabetes mellitus are already present in this young population.
C1 [Norris, Anne L.; Steinberger, Julia; Metzig, Andrea M.; Schwarzenberg, Sarah Jane; Kelly, Aaron S.] Univ Minnesota, Sch Med, Dept Pediat, Minneapolis, MN 55455 USA.
   [Steffen, Lyn M.] Univ Minnesota, Sch Publ Hlth, Div Epidemiol, Minneapolis, MN 55455 USA.
C3 University of Minnesota System; University of Minnesota Twin Cities;
   University of Minnesota System; University of Minnesota Twin Cities
RP Kelly, AS (corresponding author), Univ Minnesota, Sch Med, Dept Pediat, Minneapolis, MN 55455 USA.
EM kelly105@umn.edu
OI Steinberger, Julia/0000-0002-2892-8594; Steffen, Lyn
   M/0000-0002-4053-6729
FU University of Minnesota; National Institutes of Health: NCI/NIDDK
   [1RO1CA113930-01A1]; GCRC [M01-RR00400]; General Clinical Research
   Center Program, NCRR/NIH
FX Funding for this study was provided by the University of Minnesota
   Vikings Children's Fund (A. S. K.), National Institutes of Health:
   NCI/NIDDK: 1RO1CA113930-01A1 (J.S.), and GCRC: M01-RR00400, General
   Clinical Research Center Program, NCRR/NIH. Statistical analysis was
   provided by Jae Choi (Macalester College, St Paul, MN) and Philippe
   Gaillard, PhD (Biostatistical Design and Analysis Center, University of
   Minnesota Clinical and Translational Science Institute, Minneapolis,
   MN).
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NR 40
TC 72
Z9 85
U1 0
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1930-7381
EI 1930-739X
J9 OBESITY
JI Obesity
PD JUL
PY 2011
VL 19
IS 7
BP 1415
EP 1419
DI 10.1038/oby.2011.21
PG 5
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 784CU
UT WOS:000292132300014
PM 21331062
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Oben, JE
   Enyegue, DM
   Fomekong, GI
   Soukontoua, YB
   Agbor, GA
AF Oben, Julius E.
   Enyegue, Damaris Mandob
   Fomekong, Gilles I.
   Soukontoua, Yves B.
   Agbor, Gabriel A.
TI The effect of Cissus quadrangularis (CQR-300) and a Cissus formulation
   (CORE) on obesity and obesity-induced oxidative stress
SO LIPIDS IN HEALTH AND DISEASE
LA English
DT Article
ID DENSITY-LIPOPROTEIN; METABOLIC SYNDROME; WEIGHT-LOSS; ANTIOXIDANTS;
   CHOLESTEROL; ASSOCIATION; ORLISTAT; GRAPES
AB Aim: Obesity is generally linked to complications in lipid metabolism and oxidative stress. The aim of this study was to compare the effect of a proprietary extract of Cissus quadrangularis (CQR-300) to that of a proprietary formulation containing CQR-300 (CORE) on weight, blood lipids, and oxidative stress in overweight and obese people.
   Methods: The first part of the study investigated the in vitro antioxidant properties of CQR-300 and CORE using 3 different methods, while the second part of the study was a double-blind placebo controlled design, involving initially 168 overweight and obese persons (38.7% males; 61.3% females; ages 19-54), of whom 153 completed the study. All participants received two daily doses of CQR-300, CORE, or placebo and were encouraged to maintain their normal levels of physical activity. Anthropometric measurements and blood sampling were done at the beginning and end of the study period.
   Results: CQR-300 as well as CORE exhibited antioxidant properties in vitro. They also acted as in vivo antioxidants, bringing about significant (p < 0.001) reductions in plasma TBARS and carbonyls. Both CQR-300 and CORE also brought about significant reductions in weight, body fat, total cholesterol, LDL-cholesterol, triglycerides, and fasting blood glucose levels over the respective study periods. These changes were accompanied by a significant increase in HDL-cholesterol levels, plasma 5-HT, and creatinine.
   Conclusion: CQR-300 (300 mg daily) and CORE (1028 mg daily) brought about significant reductions in weight and blood glucose levels, while decreasing serum lipids thus improving cardiovascular risk factors. The increase in plasma 5-HT and creatinine for both groups hypothesizes a mechanism of controlling appetite and promoting the increase of lean muscle mass by Cissus quadrangularis, thereby supporting the clinical data for weight loss and improving cardiovascular health.
C1 Univ Yaounde, Lab Nutr & Nutr Biochem, Dept Biochem, Yaounde, Cameroon.
   Inst Med Res & Med Plants Studies, CRPMT, Yaounde, Cameroon.
C3 University of Yaounde I
RP Oben, JE (corresponding author), Univ Yaounde, Lab Nutr & Nutr Biochem, Dept Biochem, BP 812, Yaounde, Cameroon.
EM juliusoben@hotmail.com; damand04@yahoo.fr; fdogines@yahoo.fr;
   soukyberto@yahoo.fr; agoga@yahoo.fr
RI Agbor, Gabriel/AAZ-7990-2020; Agbor, Gabriel/J-8377-2013
OI Agbor, Gabriel/0000-0001-5860-9853
CR AGBOR AG, IN PRESS NUTR RES
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NR 45
TC 53
Z9 67
U1 0
U2 10
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1476-511X
J9 LIPIDS HEALTH DIS
JI Lipids Health Dis.
PD FEB 4
PY 2007
VL 6
AR 4
DI 10.1186/1476-511X-6-4
PG 8
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA 182FQ
UT WOS:000247490900001
PM 17274828
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Huzum, B
   Chirila, I
   Veliceasa, B
   Puha, B
   Costache, AD
   Filip, A
   Morariu, BA
   Huzum, RM
   Lupu, A
   Sirbu, D
   Serban, IL
   Alexa, O
AF Huzum, B.
   Chirila, I.
   Veliceasa, B.
   Puha, B.
   Costache, A. D.
   Filip, A.
   Morariu, B-A.
   Huzum, Riana Maria
   Lupu, Ancua
   Sirbu, D.
   Serban, Ionela Lacramioara
   Alexa, O.
TI WEIGHT LOSS AND NUTRITIONAL STATUS IN YOUNG AND MIDDLE-AGED ADULTS:
   RATIONAL APPROACH AND HEALTH IMPLICATIONS
SO MEDICAL-SURGICAL JOURNAL-REVISTA MEDICO-CHIRURGICALA
LA English
DT Article
DE EXERCISE; WEIGHT-LOSS; BMI; WAIST-TO-HIP RATIO; DIET RESTRICTION;
   OXIDATIVE STRESS
ID PHYSICAL-ACTIVITY; OXIDATIVE STRESS; CARDIORESPIRATORY FITNESS;
   CARDIOVASCULAR-DISEASE; LIFE-STYLE; OBESITY; OVERWEIGHT; MORTALITY;
   EXERCISE; ADIPOSITY
AB Obesity is considered a major epidemic of the 21st century in many countries including Romania. Often, obesity is correlated with oxidative stress, metabolic syndrome and cardiovascular problems, which on the long-term increases the risk to diabetes and heart failure. The chances of long-term successful weight loss are enhanced by exercise and the sustained exercise is recommended as a non-invasive approach for the prevention and management of modern civilization diseases. The aim of the retrospective study was to monitor the evolution of body weight and some indicators that reflected the weight status of young and middle-aged adults, who exercised in an organized manner in gyms in the city of Iasi (Romania) by following the evolution of anthropometric parameters from the monitoring sheets of subjects who performed physical exercises in two gyms in Iasi. Material and methods: Data were extracted on socio-demographic aspects (sex, age, level of education, occupation) and physical status (height, weight, body perimeters) at the beginning of the organized physical exercises regimen and after a certain period of regular exercises. Results: Moreover, the respondents followed a caloric restrictive diet, using high protein bars to replace one of their meals. The average weight loss rate was -0.83 +/- 0.48 kg/month, higher in men (-1.12 kg/month, maximum 2.9 kg/month) than in women (-0.69 kg/month, maximum 3 kg/month). Conclusions: Strict diet and exercise regimen monitorization may have a better impact on weight loss, than allowing a free choice of hypocaloric diet and a standard exercise program. However, all available data shows that reducing overweight has long-term benefits on oxidative burden for obese individuals.
C1 [Huzum, B.; Veliceasa, B.; Puha, B.; Costache, A. D.; Filip, A.; Huzum, Riana Maria; Lupu, Ancua; Sirbu, D.; Serban, Ionela Lacramioara; Alexa, O.] Grigore T Popa Univ Med & Pharm, Fac Med, Iasi, Romania.
   [Chirila, I.] Natl Inst Publ Hlth, Iasi, Romania.
   [Morariu, B-A.] Sf Spiridon Cty Clin Emergency Hosp, Iasi, Romania.
C3 Grigore T Popa University of Medicine & Pharmacy
RP Costache, AD (corresponding author), Grigore T Popa Univ Med & Pharm, Fac Med, Iasi, Romania.
EM dan-alexandru.costache@umfiasi.ro
RI Serban, Ionela Lacramioara/GZL-6671-2022; Veliceasa,
   Bogdan/AFV-2751-2022; FIlip, Alexandru/HGB-1890-2022; Lupu,
   Ancuta/IVV-3125-2023
OI Lupu, Ancuta/0000-0001-8147-3632
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NR 38
TC 0
Z9 0
U1 0
U2 4
PU SOC MEDICI NATURALISTI IASI- SOC PHYSICIAN NATURALISTS
PI IASI
PA BD INDEPENDENTEI 16, PO BOX 25, IASI 6600, ROMANIA
SN 0048-7848
EI 2286-2560
J9 MED-SURG J
JI Med.-Surg. J.
PY 2023
VL 127
IS 3
BP 458
EP 473
DI 10.22551/MSJ.2023.03.15
PG 16
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA HO3G0
UT WOS:001160399800015
OA Bronze
DA 2025-06-11
ER

PT J
AU Hezel, M
   Peleli, M
   Liu, M
   Zollbrecht, C
   Jensen, BL
   Checa, A
   Giulietti, A
   Wheelock, CE
   Lundberg, JO
   Weitzberg, E
   Carlström, M
AF Hezel, Michael
   Peleli, Maria
   Liu, Ming
   Zollbrecht, Christa
   Jensen, Boye L.
   Checa, Antonio
   Giulietti, Alessia
   Wheelock, Craig E.
   Lundberg, Jon O.
   Weitzberg, Eddie
   Carlstrom, Mattias
TI Dietary nitrate improves age-related hypertension and metabolic
   abnormalities in rats via modulation of angiotensin II receptor
   signaling and inhibition of superoxide generation
SO FREE RADICAL BIOLOGY AND MEDICINE
LA English
DT Article
DE Aging; Angiotensin II receptors; Endothelial dysfunction; Hypertension;
   NADPH oxidase; Metabolic syndrome; Nitrite; Nitric oxide; Renin;
   Superoxide
ID REDUCES BLOOD-PRESSURE; SMOOTH-MUSCLE-CELLS; NITRIC-OXIDE; INORGANIC
   NITRATE; NADPH-OXIDASE; OXIDATIVE STRESS; CARDIOVASCULAR-DISEASE;
   INSULIN-SECRETION; AT(1) RECEPTORS; HEART-FAILURE
AB Advanced age is associated with increased risk for cardiovascular disease and type 2 diabetes. A proposed central event is diminished amounts of nitric oxide (NO) due to reduced generation by endothelial NO synthase (eNOS) and increased oxidative stress. In addition, it is widely accepted that increased angiotensin II (ANG II) signaling is also implicated in the pathogenesis of endothelial dysfunction and hypertension by accelerating formation of reactive oxygen species. This study was designed to test the hypothesis that dietary nitrate supplementation could reduce blood pressure and improve glucose tolerance in aged rats, via attenuation of NADPH oxidase activity and ANG II receptor signaling.
   Dietary nitrate supplementation for two weeks reduced blood pressure (10-15 mmHg) and improved glucose clearance in old, but not in young rats. These favorable effects were associated with increased insulin responses, reduced plasma creatinine as well as improved endothelial relaxation to acetylcholine and attenuated contractility to ANG II in resistance arteries. Mechanistically, nitrate reduced NADPH oxidase-mediated oxidative stress in the cardiovascular system and increased cGMP signaling. Finally, nitrate treatment in aged rats normalized the gene expression profile of ANG II receptors (AT(1A), AT(2), AT(1A)/AT(2) ratio) in the renal and cardiovascular systems without altering plasma levels of renin or ANG II.
   Our results show that boosting the nitrate-nitrite-NO pathway can partly compensate for age-related disturbances in endogenous NO generation via inhibition of NADPH oxidase and modulation of ANG II receptor expression. These novel findings may have implications for nutrition-based preventive and therapeutic strategies against cardiovascular and metabolic diseases. (C) 2016 Elsevier Inc. All rights reserved.
C1 [Hezel, Michael; Peleli, Maria; Liu, Ming; Zollbrecht, Christa; Giulietti, Alessia; Lundberg, Jon O.; Weitzberg, Eddie; Carlstrom, Mattias] Karolinska Inst, Dept Physiol & Pharmacol, S-17177 Stockholm, Sweden.
   [Jensen, Boye L.] Univ Southern Denmark, Dept Cardiovasc & Renal Res, DK-5230 Odense, Denmark.
   [Checa, Antonio; Wheelock, Craig E.] Karolinska Inst, Dept Med Biochem & Biophys, S-17177 Stockholm, Sweden.
C3 Karolinska Institutet; University of Southern Denmark; Karolinska
   Institutet
RP Carlström, M (corresponding author), Karolinska Inst, Dept Physiol & Pharmacol, S-17177 Stockholm, Sweden.
EM mihezel@gmail.com; Mattias.Carlstrom@ki.se
RI Peleli, Maria/AAQ-2326-2021; Carlstrom, Mattias/E-7350-2015
OI Carlstrom, Mattias/0000-0001-9923-8729; Checa,
   Antonio/0000-0002-0674-3329; Lundberg, Jon/0000-0002-0174-5210
FU Swedish Research Council [521-2011-2639]; Swedish Heart and Lung
   Foundation [20140448]; David and Astrid Hagelen Foundation; Jeanssons
   Foundation [J52013-00064]; Stockholm City Council (ALF); Bodossaki
   Foundation (Athens, Greece); Karolinska Institutet [2415/2012-225,
   2-3707/2013]
FX This work was supported by grants from the Swedish Research Council
   (521-2011-2639), the Swedish Heart and Lung Foundation (20140448), David
   and Astrid Hagelen Foundation (Dnr 2014-2015), Jeanssons Foundation
   (J52013-00064), Stockholm City Council (ALF, Dnr 2014-2015), the
   Bodossaki Foundation (Athens, Greece, Dnr 2012-2015) and by KID-funding
   from the Karolinska Institutet (Dnr 2415/2012-225 and Dnr 2-3707/2013).
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NR 51
TC 65
Z9 69
U1 0
U2 10
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0891-5849
EI 1873-4596
J9 FREE RADICAL BIO MED
JI Free Radic. Biol. Med.
PD OCT
PY 2016
VL 99
BP 87
EP 98
DI 10.1016/j.freeradbiomed.2016.07.025
PG 12
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA EC3AD
UT WOS:000387995400010
PM 27474450
DA 2025-06-11
ER

PT J
AU Valenzuela, R
   Espinosa, A
   Llanos, P
   Hernandez-Rodas, MC
   Barrera, C
   Vergara, D
   Romero, N
   Pérez, F
   Ruz, M
   Videla, LA
AF Valenzuela, Rodrigo
   Espinosa, Alejandra
   Llanos, Paola
   Catalina Hernandez-Rodas, Maria
   Barrera, Cynthia
   Vergara, Daniela
   Romero, Nalda
   Perez, Francisco
   Ruz, Manuel
   Videla, Luis A.
TI Anti-steatotic effects of an n-3 LCPUFA and extra virgin olive oil
   mixture in the liver of mice subjected to high-fat diet
SO FOOD & FUNCTION
LA English
DT Article
ID OXIDATIVE STRESS; INSULIN-RESISTANCE; METABOLIC SYNDROME; HEART-DISEASE;
   ACID; OMEGA-3-FATTY-ACIDS; INFLAMMATION; ANTIOXIDANT; ACTIVATION;
   MECHANISMS
AB Non-alcoholic fatty liver disease (NAFLD) is characterized by liver steatosis, oxidative stress, and drastic depletion of n-3 long-chain polyunsaturated fatty acids (n-3 LCPUFA), namely, eicosapentaenoic acid (C20: 5 n-3, EPA) and docosahexaenoic acid (C22: 6 n-3, DHA), which trigger lipolysis stimulation and lipogenesis inhibition. Extra virgin olive oil (EVOO) has important antioxidant effects. This study evaluated the anti-steatotic effects of n-3 LCPUFA plus EVOO in the liver of male C57BL/6J mice subjected to a control diet (CD) (10% fat, 20% protein, 70% carbohydrate) or high fat diet (HFD) (60% fat, 20% protein, 20% carbohydrate), without and with supplementation with n-3 LCPUFA (100 mg per kg per day) plus EVOO (100 mg per kg per day) for 12 weeks. HFD induced (i) liver steatosis (increased total fat, triacylglycerols, and free fatty acid total contents), (ii) higher fasting serum glucose and insulin levels and HOMA index, total cholesterol, triacylglycerols and TNF-alpha and IL-6, (iii) liver and plasma oxidative stress enhancement, (iv) depletion of the n-3 LCPUFA hepatic content, and (v) increment in lipogenic enzyme activity and reduction in lipolytic enzyme activity. These changes were either reduced (p < 0.05) or normalized to control the values in animals subjected to HFD supplemented with n-3 LCPUFA plus EVOO. In conclusion, n-3 LCPUFA plus EVOO intervention exerts anti-steatotic effects underlying antioxidant and antiinflammatory responses, improved insulin sensitivity, and recovery of the lipolytic/lipogenic status of the liver altered by HFD, and supports the potential therapeutic use of n-3 LCPUFA plus EVOO supplementation in the treatment of human liver steatosis induced by nutritional factors or other etiologies.
C1 [Valenzuela, Rodrigo; Catalina Hernandez-Rodas, Maria; Barrera, Cynthia; Vergara, Daniela; Perez, Francisco; Ruz, Manuel] Univ Chile, Fac Med, Dept Nutr, Santiago 7, Chile.
   [Espinosa, Alejandra] Univ Chile, Fac Med, Med Technol Dept, Santiago 7, Chile.
   [Llanos, Paola] Univ Chile, Fac Dent, Inst Res Dent Sci, Santiago, Chile.
   [Romero, Nalda] Univ Chile, Fac Chem Sci & Pharm, Dept Food Sci & Chem Technol, Santiago, Chile.
   [Videla, Luis A.] Univ Chile, Fac Med, Inst Biomed Sci, Mol & Clin Pharmacol Program, Santiago 7, Chile.
C3 Universidad de Chile; Universidad de Chile; Universidad de Chile;
   Universidad de Chile; Universidad de Chile
RP Valenzuela, R (corresponding author), Univ Chile, Fac Med, Dept Nutr, Santiago 7, Chile.
EM rvalenzuelab@med.uchile.cl
RI Hernández-Rodas, María/ABG-5275-2021; Espinosa, Alejandra/ISB-7050-2023;
   Perez Rodríguez, Francisco/GRN-8495-2022; Barrera, Cynthia/I-7108-2015
OI Barrera, Cynthia/0000-0002-7762-5696; Hernandez Rodas, Maria
   Catalina/0000-0001-9516-4056; Ruz, Manuel/0000-0001-6010-8409; Llanos,
   Paola/0000-0003-1383-7961
FU Chilean Endocrinology and Diabetes Society (SOCHED) [2013-04];
   Initiation FONDECYT (National Fund for Scientific and Technological
   Development) [11140174]; Enlaza-Mundos Program of the Mayor of Medellin
   (Colombia) - Agency for Higher Education of Medellin-SAPIENCIA
FX The authors are grateful to the Chilean Endocrinology and Diabetes
   Society (SOCHED 2013-04 PROJECT to R. V.) and grant (11140174) from
   Initiation FONDECYT (National Fund for Scientific and Technological
   Development) to R. V. for supporting this study. Finally, the
   Enlaza-Mundos Program of the Mayor of Medellin (Colombia) - Agency for
   Higher Education of Medellin-SAPIENCIA, for the support to co-finance
   postgraduate study abroad (Maria Catalina Hernandez-Rodas).
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NR 50
TC 34
Z9 35
U1 0
U2 15
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PY 2016
VL 7
IS 1
BP 140
EP 150
DI 10.1039/c5fo01086a
PG 11
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA DB9TO
UT WOS:000368860000013
PM 26471014
DA 2025-06-11
ER

PT J
AU Lozovoy, MAB
   Simao, ANC
   Morimoto, HK
   Iryioda, TMV
   Panis, C
   Reiche, EMV
   Borelli, SD
   Oliveira, SR
   Cecchini, R
   Dichi, I
AF Lozovoy, M. A. B.
   Simao, A. N. C.
   Morimoto, H. K.
   Iryioda, T. M. V.
   Panis, C.
   Reiche, E. M. V.
   Borelli, S. D.
   Oliveira, S. R.
   Cecchini, R.
   Dichi, I.
TI Hypertension is associated with serologically active disease in patients
   with systemic lupus erythematosus: role of increased Th1/Th2 ratio and
   oxidative stress
SO SCANDINAVIAN JOURNAL OF RHEUMATOLOGY
LA English
DT Article
ID METABOLIC SYNDROME; ACTIVATION; CYTOKINES; TISSUE; BLOOD; LIVER
AB Objectives: To determine whether disease activity verified by laboratorial parameters is associated with a higher frequency of hypertension in patients with systemic lupus erythematosus (SLE) without renal impairment and to investigate factors that could influence this hypertension.
   Method: This study included 102 controls, 70 patients with inactive SLE, and 53 patients with active SLE without renal impairment. We evaluated T helper type 1 (Th1)/Th2 lineage cytokines, nitric oxide (NO), insulin resistance (IR), and oxidative stress.
   Results: Patients with active SLE had a higher probability of developing hypertension compared to controls [odds ratio (OR) 3.833, 95% confidence interval (CI) 1.806-8.137, p<0.0003] and patients with inactive SLE (OR 2.215, 95% CI 1.032-4.752, p = 0.0394). Active SLE patients had a higher interleukin (IL)-12/IL-4 ratio (p < 0.05) than both controls and inactive SLE patients. Protein oxidation was significantly higher in patients with active SLE than in the control group and in patients with inactive SLE (p < 0.01 and p < 0.05, respectively). Multivariate analysis revealed an association between the presence of hypertension and he levels of glucose (p = 0.0276), insulin (p = 0.0498), hydroperoxides (p = 0.0221), IFN-gamma (p = 0.0494), IL-17 (p = 0.0272), IL-12/IL-10 (p = 0.0373), IFN-gamma/IL-10 (p = 0.0142), IFN-gamma/IL-4 (p = 0.0320), and adiponectin (p = 0.0433).
   Conclusions: Patients with active SLE without renal impairment had an increased frequency of high blood pressure (43.4%) compared with patients with inactive SLE (25.7%) and controls (16.7%). Hypertension was associated with serologically active disease and was influenced by an increased Th1/Th2 ratio and oxidative stress.
C1 [Lozovoy, M. A. B.] Univ North Parana UNOPAR, Dept Clin Anal, Londrina, Parana, Brazil.
   [Simao, A. N. C.; Morimoto, H. K.; Reiche, E. M. V.; Oliveira, S. R.] Univ Londrina, Dept Pathol Clin Anal & Toxicol, BR-86000000 Londrina, Parana, Brazil.
   [Iryioda, T. M. V.; Dichi, I.] Univ Londrina, Dept Internal Med, BR-86000000 Londrina, Parana, Brazil.
   [Panis, C.; Cecchini, R.] Univ Londrina, Lab Pathophysiol Free Rad, BR-86000000 Londrina, Parana, Brazil.
   [Borelli, S. D.] Univ Estadual Maringa, Dept Clin Anal, Maringa, Parana, Brazil.
C3 University Norte Parana; Universidade Estadual de Maringa
RP Simao, ANC (corresponding author), Univ Londrina, Dept Clin Pathol Clin Anal & Toxicol, Robert Koch Ave 60, BR-86000000 Londrina, Parana, Brazil.
EM deianame@yahoo.com.br
RI Lozovoy, Marcell/AAM-4897-2021; Reiche, EDNa/AAD-4186-2020; Simão,
   Andrea/AAM-4892-2021; Cecchini, Rubens/D-9811-2013; PANIS,
   CAROLINA/O-1490-2015; Reiche, Edna Maria Vissoci/C-4102-2013
OI Cecchini, Rubens/0000-0001-9941-2344; PANIS,
   CAROLINA/0000-0002-0104-4369; Reiche, Edna Maria
   Vissoci/0000-0001-6507-2839
FU University of Londrina Research Funds (FAEPE)
FX This work was supported by the University of Londrina Research Funds
   (FAEPE).
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NR 16
TC 22
Z9 26
U1 0
U2 5
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0300-9742
EI 1502-7732
J9 SCAND J RHEUMATOL
JI Scand. J. Rheumatol.
PY 2014
VL 43
IS 1
BP 59
EP 62
DI 10.3109/03009742.2013.834963
PG 4
WC Rheumatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Rheumatology
GA 302GJ
UT WOS:000330590300010
PM 24134304
DA 2025-06-11
ER

PT J
AU Feillet-Coudray, C
   Aoun, M
   Fouret, G
   Bonafos, B
   Ramos, J
   Casas, F
   Cristol, JP
   Coudray, C
AF Feillet-Coudray, Christine
   Aoun, Manar
   Fouret, Gilles
   Bonafos, Beatrice
   Ramos, Jeanne
   Casas, Francois
   Cristol, Jean Paul
   Coudray, Charles
TI Effects of long-term administration of saturated and n-3 fatty
   acid-rich diets on lipid utilisation and oxidative stress in rat liver
   and muscle tissues
SO BRITISH JOURNAL OF NUTRITION
LA English
DT Article
DE SFA; n-3 PUFA; High-lipid diets; Steatosis; Insulin resistance;
   Oxidative stress; Mitochondria
ID ESTIMATED DESATURASE ACTIVITIES; SKELETAL-MUSCLE; INSULIN-RESISTANCE;
   GENE-EXPRESSION; MEMBRANE; OMEGA-3-FATTY-ACIDS; ACCUMULATION; DISEASE;
   QUALITY; OBESITY
AB The incidence of metabolic syndrome components including obesity, lipid deregulation, insulin resistance (IR) and non-alcoholic fatty liver disease is increasing rapidly in wealthy societies. The present study was designed to determine the effect of different nutritional lipid patterns (quantity and quality) on lipid utilisation and oxidative stress in the liver and muscle of rats in an integrated fashion. A total of forty-eight Wistar male rats were fed for 12 weeks with a mixed, lard or fish-oil diet, containing either 50 or 300 g lipid/kg. Rats developed liver steatosis associated with moderate liver injury when fed the 30% lipid diets, in spite of the absence of overt obesity or IR, except when fed the lard 30% lipid diet. The intake of the 30% lipid diets decreased hepatic lipogenesis and mitochondriogenesis and increased lipid peroxidation and protein oxidation. Surprisingly, muscle lipid content was not modified whatever the administered diet. The intake of the 30% lipid diets increased the muscle protein expression of fatty acid (FA) translocase/cluster of differentiation 36 (FAT/CD36), PPAR gamma co-activator 1 alpha (PGC-1 alpha) and muscle carnitine palmitoyltransferase 1 (m-CPT1), reflecting increased FA transport in the muscle associated with increased oxidative metabolism. The lard 30% lipid diet led to IR without modifying the muscle lipid content. The fish-oil 30% lipid diet failed to prevent the development of hepatic steatosis and made the tissues more prone to oxidation. Overall, the present study suggests that the FA composition of muscle is more important than lipid accumulation itself in the modulation of insulin sensitivity, and indicates that precaution should be taken when advising an unphysiologically high (pharmacological) supplementation with long-chain n-3 PUFA.
C1 [Feillet-Coudray, Christine; Fouret, Gilles; Bonafos, Beatrice; Casas, Francois; Coudray, Charles] INRA, UMR Dynam Musculaire & Metab 866, F-34060 Montpellier, France.
   [Aoun, Manar; Cristol, Jean Paul] NUTRIPASS IRD Montpellier 1 Montpellier 2 Supagro, UMR 204, F-34000 Montpellier, France.
   [Ramos, Jeanne] CHU Gui de Chauliac, Anat Pathol Lab, F-34295 Montpellier 5, France.
C3 INRAE; Universite de Montpellier; Institut Agro; Montpellier SupAgro;
   Institut de Recherche pour le Developpement (IRD); Universite de
   Montpellier; Universite de Montpellier; CHU de Montpellier
RP Feillet-Coudray, C (corresponding author), INRA, UMR Dynam Musculaire & Metab 866, F-34060 Montpellier, France.
EM cfeillet@supagro.inra.fr
RI COUDRAY, Charles/AGG-4757-2022
OI Francois, Casas/0000-0002-5535-8195; Coudray,
   Charles/0000-0003-2680-7796; , Jean-Paul Cristol/0000-0001-8563-7278
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NR 43
TC 34
Z9 35
U1 0
U2 24
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1145
EI 1475-2662
J9 BRIT J NUTR
JI Br. J. Nutr.
PD NOV 28
PY 2013
VL 110
IS 10
BP 1789
EP 1802
DI 10.1017/S0007114513001311
PG 14
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 250VF
UT WOS:000326883600006
PM 23656726
OA Green Submitted, Bronze
DA 2025-06-11
ER

PT J
AU Cai, WJ
   Ramdas, M
   Zhu, L
   Chen, X
   Striker, GE
   Vlassara, H
AF Cai, Weijing
   Ramdas, Maya
   Zhu, Li
   Chen, Xue
   Striker, Gary E.
   Vlassara, Helen
TI Oral advanced glycation endproducts (AGEs) promote insulin resistance
   and diabetes by depleting the antioxidant defenses AGE receptor-1 and
   sirtuin 1
SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF
   AMERICA
LA English
DT Article
DE glycotoxins; obesity; aging
ID END-PRODUCTS; OXIDATIVE STRESS; OXIDANT STRESS; INFLAMMATORY RESPONSE;
   METABOLIC SYNDROME; MESANGIAL CELLS; DOWN-REGULATION; RISK-FACTOR;
   LIFE-SPAN; METHYLGLYOXAL
AB The epidemics of insulin resistance (IR) and type 2 diabetes (T2D) affect the first world as well as less-developed countries, and now affect children as well. Persistently elevated oxidative stress and inflammation (OS/Infl) precede these polygenic conditions. A hallmark of contemporary lifestyle is a preference for thermally processed nutrients, replete with pro-OS/Infl advanced glycation endproducts (AGEs), which enhance appetite and cause overnutrition. We propose that chronic ingestion of oral AGEs promotes IR and T2D. The mechanism(s) involved in these findings were assessed in four generations of C57BL6 mice fed isocaloric diets with or without AGEs [synthetic methyl-glyoxal-derivatives (MG(+))]. F3/MG(+) mice manifested increased adiposity and premature IR, marked by severe deficiency of anti-AGE advanced glycation receptor 1 (AGER1) and of survival factor sirtuin 1 (SIRT1) in white adipose tissue (WAT), skeletal muscle, and liver. Impaired 2-deoxy-glucose uptake was associated with marked changes in insulin receptor (InsR), IRS-1, IRS-2, Akt activation, and a macrophage and adipocyte shift to a pro-OS/inflammatory (M1) phenotype. These features were absent in F3/MG(-) mice. MG stimulation of 3T3-L1 adipocytes led to suppressed AGER1 and SIRT1, and altered InsR, IRS-1, IRS-2 phosphorylation, and nuclear factor kappa-light chain enhancer of activated B cells (Nf-kappa B) p65 acetylation. Gene modulation revealed these effects to be coregulated by AGER1 and SIRT1. Thus, prolonged oral exposure to MG-AGEs can deplete host-defenses AGER1 and SIRT1, raise basal OS/Infl, and increase susceptibility to dysmetabolic IR. Because exposure to AGEs can be decreased, these insights provide an important framework for alleviating a major lifestyle-linked disease epidemic.
C1 [Cai, Weijing; Ramdas, Maya; Zhu, Li; Chen, Xue; Striker, Gary E.; Vlassara, Helen] Mt Sinai Sch Med, Dept Geriatr, New York, NY 10029 USA.
   [Striker, Gary E.; Vlassara, Helen] Mt Sinai Sch Med, Dept Med, New York, NY 10029 USA.
C3 Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at
   Mount Sinai
RP Vlassara, H (corresponding author), Mt Sinai Sch Med, Dept Geriatr, New York, NY 10029 USA.
EM helen.vlassara@mssm.edu
FU MERIT Grant from the National Institutes of Health [AG-09453]; 
   [AG23188];  [HL73417]
FX This work was supported by AG23188, HL73417, and MERIT Grant AG-09453
   (to H.V.) from the National Institutes of Health.
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NR 45
TC 261
Z9 280
U1 0
U2 71
PU NATL ACAD SCIENCES
PI WASHINGTON
PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA
SN 0027-8424
J9 P NATL ACAD SCI USA
JI Proc. Natl. Acad. Sci. U. S. A.
PD SEP 25
PY 2012
VL 109
IS 39
BP 15888
EP 15893
DI 10.1073/pnas.1205847109
PG 6
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 017QD
UT WOS:000309604500073
PM 22908267
OA Green Published
DA 2025-06-11
ER

PT J
AU Berezin, AE
   Berezin, AA
   Lichtenauer, M
AF Berezin, Alexander E.
   Berezin, Alexander A.
   Lichtenauer, Michael
TI Emerging Role of Adipocyte Dysfunction in Inducing Heart Failure Among
   Obese Patients With Prediabetes and Known Diabetes Mellitus
SO FRONTIERS IN CARDIOVASCULAR MEDICINE
LA English
DT Review
DE adipose tissue; cardiac and vascular remodeling; heart failure;
   co-morbidities; biomarkers
ID BROWN ADIPOSE-TISSUE; RENIN-ANGIOTENSIN SYSTEM; BINDING-PROTEIN 4;
   INSULIN-RESISTANCE; SKELETAL-MUSCLE; METABOLIC SYNDROME; TNF-ALPHA;
   EJECTION FRACTION; SERUM RESISTIN; PATHOPHYSIOLOGICAL ROLES
AB Adipose tissue dysfunction is a predictor for cardiovascular (CV) events and heart failure (HF) in patient population with obesity, metabolic syndrome, and known type 2 diabetes mellitus. Previous preclinical and clinical studies have yielded controversial findings regarding the role of accumulation of adipose tissue various types in CV risk and HF-related clinical outcomes in obese patients. There is evidence for direct impact of infiltration of epicardial adipocytes into the underlying myocardium to induce adverse cardiac remodeling and mediate HF development and atrial fibrillation. Additionally, perivascular adipocytes accumulation is responsible for release of proinflammatory adipocytokines (adiponectin, leptin, resistin), stimulation of oxidative stress, macrophage phenotype switching, and worsening vascular reparation, which all lead to microvascular inflammation, endothelial dysfunction, atherosclerosis acceleration, and finally to increase in CV mortality. However, systemic effects of white and brown adipose tissue can be different, and adipogenesis including browning of adipose tissue and deficiency of anti-inflammatory adipocytokines (visfatin, omentin, zinc-alpha 2-glycoprotein, glypican-4) was frequently associated with adipose triglyceride lipase augmentation, altered glucose homeostasis, resistance to insulin of skeletal muscles, increased cardiomyocyte apoptosis, lowered survival, and weak function of progenitor endothelial cells, which could significantly influence on HF development, as well as end-organ fibrosis and multiple comorbidities. The exact underlying mechanisms for these effects are not fully understood, while they are essential to help develop improved treatment strategies. The aim of the review is to summarize the evidence showing that adipocyte dysfunction may induce the onset of HF and support advance of HF through different biological mechanisms involving inflammation, pericardial, and perivascular adipose tissue accumulation, adverse and electrical cardiac remodeling, and skeletal muscle dysfunction. The unbalancing effects of natriuretic peptides, neprilysin, and components of renin-angiotensin system, as exacerbating cause of altered adipocytokine signaling on myocardium and vasculature, in obesity patients at high risk of HF are disputed. The profile of proinflammatory and anti-inflammatory adipocytokines as promising biomarker for HF risk stratification is discussed in the review.
C1 [Berezin, Alexander E.] State Med Univ, Internal Med Dept, Minist Hlth Ukraine, Zaporozhe, Ukraine.
   [Berezin, Alexander A.] Med Acad Postgrad Educ, Internal Med Dept, Minist Hlth Ukraine, Zaporozhe, Ukraine.
   [Lichtenauer, Michael] Paracelsus Med Univ Salzburg, Dept Internal Med 2, Div Cardiol, Salzburg, Austria.
C3 Zaporizhzhia State Medical University; Ministry of Health of Ukraine;
   Zaporizhzhia State Medical & Pharmaceutical University; Ministry of
   Health of Ukraine; Paracelsus Private Medical University
RP Berezin, AE (corresponding author), State Med Univ, Internal Med Dept, Minist Hlth Ukraine, Zaporozhe, Ukraine.
EM aeberezin@gmail.com
RI Lichtenauer, Michael/H-5139-2019; Berezin, Alexander/B-9032-2014
OI Berezin, Alexander/0000-0002-0446-3999
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NR 242
TC 34
Z9 35
U1 0
U2 16
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2297-055X
J9 FRONT CARDIOVASC MED
JI Front. Cardiovasc. Med.
PD NOV 2
PY 2020
VL 7
AR 583175
DI 10.3389/fcvm.2020.583175
PG 20
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA OR2XS
UT WOS:000589338800001
PM 33240938
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Neamtu, AA
   Szoke-Kovacs, R
   Mihok, E
   Georgescu, C
   Turcus, V
   Olah, NK
   Frum, A
   Tita, O
   Neamtu, C
   Szoke-Kovacs, Z
   Cziaky, Z
   Mathe, E
AF Neamtu, Andreea-Adriana
   Szoke-Kovacs, Rita
   Mihok, Emoke
   Georgescu, Cecilia
   Turcus, Violeta
   Olah, Neli Kinga
   Frum, Adina
   Tita, Ovidiu
   Neamtu, Carmen
   Szoke-Kovacs, Zsombor
   Cziaky, Zoltan
   Mathe, Endre
TI Bilberry (Vaccinium myrtillus L.) Extracts Comparative Analysis
   Regarding Their Phytonutrient Profiles, Antioxidant Capacity along with
   the In Vivo Rescue Effects Tested on a Drosophila melanogaster
   High-Sugar Diet Model
SO ANTIOXIDANTS
LA English
DT Article
DE bilberry; phytochemical; antioxidant activity; flavonoid; polyphenol;
   hemolymph trehalose; insulin resistance; metabolic syndrome; Drosophila
   melanogaster
ID INDUCED ENDOTHELIAL DYSFUNCTION; INSULIN-DEGRADING ENZYME; MUSCLE
   PROTEIN-SYNTHESIS; NITRIC-OXIDE SYNTHASE; HUMAN CANCER-CELLS; EXTENDS
   LIFE-SPAN; OXIDATIVE STRESS; CHLOROGENIC ACID; PHENOLIC-COMPOUNDS;
   INDUCED APOPTOSIS
AB Bilberries (Vaccinium myrtillus L.) have been reported to hold a plentitude of health-promoting properties beyond basic nutrition, mainly attributed to their anthocyanin content and antioxidant activity. In this article, we built the phytochemical profile of three wild bilberry fruit extract formulations (aqueous, methanolic, and hydro-methanolic) using UHPLC-ESI-MS/MS putative analysis, identifying 88 individual phytochemicals, mainly flavonoids (total content 8.41 +/- 0.11 mg QE/g dw), free amino acids, polyphenols (total content 21.68 +/- 0.19 mg GAE/g dw), carboxylic acids, and vitamins. Furthermore, the antioxidant activity of the extract was assessed, reaching 78.03 +/- 0.16% DPPH free radical scavenging activity, comparable to literature values determined for bilberry extracts of other origin. Due to the increased prevalence of metabolic syndrome and based on the reviewed benefits of bilberries, we tested the most potent formulation of our bilberry extracts in this biological context. The in vivo rescue effect of a bilberry extract supplemented diet on Drosophila melanogaster was assessed by monitoring biochemical and genomic markers. Hemolymph trehalose levels were halved upon addition of 3% hydro-methanolic bilberry extract to a high-sugar (1.5 M sucrose) diet, as compared to the non-supplemented high-sugar diet. Noteworthy, the rescue seen for flies kept on the bilberry extract supplemented high-sugar diet appeared to parallel the trehalose levels observed in the case of the control diet (50 mM sucrose) flies. Moreover, next to the trehalose-lowering type of in vivo effects, other gene expression related rescues were also detected for genes such as InR, Akh, AstA, AstC, Irk, Npc2g, and CCHa2 upon supplementation of the high-sugar diet with our hydro-methanolic bilberry fruit extract. Our findings suggest that such a bilberry fruit extract could generate physiological and genomic type of compensatory mechanisms so that further translational approaches would advance the understanding of some human specific pathological conditions.
C1 [Neamtu, Andreea-Adriana] Univ Oradea, Sch Biomed Sci, Oradea 410087, Romania.
   [Szoke-Kovacs, Rita] Univ Debrecen, Fac Med, Sch Mol Cell Biol & Immunol, H-4032 Debrecen, Hungary.
   [Mihok, Emoke] Univ Debrecen, Fac Agr & Food Sci & Environm Management, Sch Anim Sci, H-4032 Debrecen, Hungary.
   [Georgescu, Cecilia; Frum, Adina; Tita, Ovidiu] Univ Sibiu, Fac Agr Sci Food Ind & Environm Protect Lucian Bl, Sibiu 550012, Romania.
   [Turcus, Violeta; Neamtu, Carmen; Mathe, Endre] Vasile Goldis Western Univ Arad, Fac Med, Arad 310045, Romania.
   [Olah, Neli Kinga] Vasile Goldis Western Univ Arad, Fac Pharm, Arad 310045, Romania.
   [Szoke-Kovacs, Zsombor] Univ Debrecen, Fac Agr & Food Sci & Environm Management, Sch Nutr, H-4032 Debrecen, Hungary.
   [Cziaky, Zoltan] Univ Nyiregyhaza, Agr & Mol Res & Serv Inst, H-4400 Nyiregyhaza, Hungary.
   [Mathe, Endre] Univ Debrecen, Fac Agr & Food Sci & Environm Management, H-4032 Debrecen, Hungary.
C3 University of Oradea; University of Debrecen; University of Debrecen;
   Lucian Blaga University of Sibiu; Vasile Goldis Western University of
   Arad; Vasile Goldis Western University of Arad; University of Debrecen;
   University of Nyiregyhaza; University of Debrecen
RP Georgescu, C (corresponding author), Univ Sibiu, Fac Agr Sci Food Ind & Environm Protect Lucian Bl, Sibiu 550012, Romania.; Mathe, E (corresponding author), Vasile Goldis Western Univ Arad, Fac Med, Arad 310045, Romania.; Mathe, E (corresponding author), Univ Debrecen, Fac Agr & Food Sci & Environm Management, H-4032 Debrecen, Hungary.
EM aneamtu94@gmail.com; takacsrita@unideb.hu; mihokemoke@uni.sapientia.ro;
   cecilia.georgescu@ulbsibiu.ro; violeta.turcus@uvvg.ro;
   olah.neli@uvvg.ro; adina.frum@ulbsibiu.ro; ovidiu.tita@ulbsibiu.ro;
   neamtu.carmen@uvvg.ro; szoke.zsombor@agr.unideb.hu;
   cziaky.zoltan@nye.hu; endre.mathe@agr.unideb.hu
RI Frum, Adina/AAC-5026-2020; NEAMTU, CARMEN/IAO-8636-2023; Szoke-Kovacs,
   Zsombor/E-2321-2017; Georgescu, Cecilia/I-7955-2019; Mathe,
   Endre/ISB-0840-2023; OVIDIU, TITA/ABB-8196-2020; Neamtu,
   Andreea-Adriana/AAJ-7540-2021
OI OVIDIU, TITA/0000-0001-5094-581X; Neamtu, Carmen/0000-0002-4766-5945;
   Neamtu, Andreea-Adriana/0000-0002-5219-5466; GEORGESCU,
   CECILIA/0000-0003-4804-1138; Szoke-Kovacs, Rita/0000-0002-1915-7783;
   Frum, Adina/0000-0003-4874-0430; Cziaky, Zoltan/0000-0002-1846-3236
FU European Union; European Social Fund;  [EFOP-3.6.3-VEKOP-16-2017-00008]
FX The research and publication is supported through the
   EFOP-3.6.3-VEKOP-16-2017-00008 grant. The project is co-financed by the
   European Union and the European Social Fund.
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NR 298
TC 26
Z9 27
U1 2
U2 48
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD NOV
PY 2020
VL 9
IS 11
AR 1067
DI 10.3390/antiox9111067
PG 33
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA OW3GV
UT WOS:000592780600001
PM 33143302
OA gold, Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Wang, Q
   Wu, Q
   Feng, J
   Sun, X
AF Wang, Qing
   Wu, Qi
   Feng, Jing
   Sun, Xin
TI Obstructive sleep apnea and endothelial progenitor cells
SO PATIENT PREFERENCE AND ADHERENCE
LA English
DT Review
DE intermittent hypoxia; systemic inflammation; oxidative stress;
   sympathetic activation; continuous positive airway pressure adherence
ID POSITIVE AIRWAY PRESSURE; NITRIC-OXIDE-SYNTHASE; C-REACTIVE PROTEIN;
   CARDIOVASCULAR RISK-FACTORS; SYMPATHETIC-NERVOUS-SYSTEM; LONG-TERM
   COMPLIANCE; OXIDATIVE STRESS; ANGIOTENSIN-II; GROWTH-FACTOR; METABOLIC
   SYNDROME
AB Background: Obstructive sleep apnea (OSA) occurs in 4% of middle-aged men and 2% of middle-aged women in the general population, and the prevalence is even higher in specific patient groups. OSA is an independent risk factor for a variety of cardiovascular diseases. Endothelial injury could be the pivotal determinant in the development of cardiovascular pathology in OSA. Endothelial damage ultimately represents a dynamic balance between the magnitude of injury and the capacity for repair. Bone marrow-derived endothelial progenitor cells (EPCs) within adult peripheral blood present a possible means of vascular maintenance that could home to sites of injury and restore endothelial integrity and normal function.
   Methods: We summarized pathogenetic mechanisms of OSA and searched for available studies on numbers and functions of EPCs in patients with OSA to explore the potential links between the numbers and functions of EPCs and OSA. In particular, we tried to elucidate the molecular mechanisms of the effects of OSA on EPCs.
   Conclusion: Intermittent hypoxia cycles and sleep fragmentation are major pathophysiologic characters of OSA. Intermittent hypoxia acts as a trigger of oxidative stress, systemic inflammation, and sympathetic activation. Sleep fragmentation is associated with a burst of sympathetic activation and systemic inflammation. In most studies, a reduction in circulating EPCs has emerged. The possible mechanisms underlying the decrease in the number or function of EPCs include prolonged inflammation response, oxidative stress, increased sympathetic activation, physiological adaptive responses of tissue to hypoxia, reduced EPC mobilization, EPC apoptosis, and functional impairment in untreated OSA. Continuous positive airway pressure (CPAP) therapy for OSA affects the mobilization, apoptosis, and function of EPCs through preventing intermittent hypoxia episodes, improving sleep quality, and reducing systemic inflammation, oxidative stress levels, and sympathetic overactivation. To improve CPAP adherence, the medical staff should pay attention to making the titration trial a comfortable first CPAP experience for the patients; for example, using the most appropriate ventilators or proper humidification. It is also important to give the patients education and support about CPAP use in the follow-up, especially in the early stage of the treatment.
C1 [Wang, Qing] First Peoples Hosp, Resp Dept 2, Kunming, Yunnan, Peoples R China.
   [Wu, Qi] Tianjin Haihe Hosp, Tianjin, Peoples R China.
   [Feng, Jing] Tianjin Med Univ, Resp Dept, Gen Hosp, Tianjin 300052, Peoples R China.
   [Feng, Jing] Duke Univ, Med Ctr, Div Pulm & Crit Care Med, Durham, NC USA.
   [Sun, Xin] Tianjin Haihe Hosp, Resp Dept, Tianjin, Peoples R China.
C3 Tianjin Medical University; Duke University
RP Feng, J (corresponding author), Tianjin Med Univ, Resp Dept, Gen Hosp, Tianjin 300052, Peoples R China.
EM zyyhxkfj@126.com; sunxin0917@126.com
FU National Natural Science Foundation of China [81270144, 30800507,
   81170071]
FX This study was supported by the grants from the National Natural Science
   Foundation of China (No 81270144, 30800507, 81170071).
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NR 166
TC 16
Z9 18
U1 0
U2 9
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1177-889X
J9 PATIENT PREFER ADHER
JI Patient Prefer. Adherence
PY 2013
VL 7
BP 1077
EP 1090
DI 10.2147/PPA.S51562
PG 14
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 235TR
UT WOS:000325744100001
PM 24204127
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Kothawade, SM
   Buttar, HS
   Tuli, HS
   Kaur, G
AF Kothawade, Sakshi M.
   Buttar, Harpal Singh
   Tuli, Hardeep Singh
   Kaur, Ginpreet
TI Therapeutic potential of flavonoids in the management of obesity-induced
   Alzheimer's disease: an overview of preclinical and clinical studies
SO NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
LA English
DT Review
DE Obesity-induced Alzheimer's disease; Oxidative stress;
   Neuro-inflammation; Animal models of Alzheimer's disease; Nutraceuticals
   containing flavonoids; Quercetin; Curcumin; Resveratrol;
   Epigallocatechin-3-gallate; Morin; Delphinidins; Luteolin; Oleocanthal
ID IN-VITRO; MECHANISM; CURCUMIN; STRESS
AB Obesity is a global epidemic that affects people of all ages, genders, and backgrounds. It can lead to a plethora of disorders, including diabetes mellitus, renal dysfunction, musculoskeletal problems, metabolic syndrome, cardiovascular, and neurodegenerative abnormalities. Obesity has also been linked to neurological diseases such as cognitive decline, dementia, and Alzheimer's disease (AD), caused by oxidative stress, pro-inflammatory cytokines, and the production of reactive oxygen free radicals (ROS). Secretion of insulin hormone is impaired in obese people, leading to hyperglycaemia and increased accumulation of amyloid-beta in the brain. Acetylcholine, a key neurotransmitter necessary for forming new neuronal connections in the brain, decreases in AD patients. To alleviate acetylcholine deficiency, researchers have proposed dietary interventions and adjuvant therapies that enhance the production of acetylcholine and assist in the management of AD patients. Such measures include dietary intervention with antioxidant and anti-inflammatory flavonoid-rich diets, which have been found to bind to tau receptors, reduce gliosis, and reduce neuroinflammatory markers in animal models. Furthermore, flavonoids like curcumin, resveratrol, epigallocatechin-3-gallate, morin, delphinidins, quercetin, luteolin, and oleocanthal have shown to cause significant reductions in interleukin-1 beta, increase BDNF levels, stimulate hippocampal neurogenesis and synapse formation, and ultimately prevent the loss of neurons in the brain. Thus, flavonoid-rich nutraceuticals can be a potential cost-effective therapeutic option for treating obesity-induced AD, but further well-designed, randomized, and placebo-controlled clinical studies are needed to assess their optimal dosages, efficacy, and long-term safety of flavonoids in humans. The main objectives of this review are to underscore the therapeutic potential of different nutraceuticals containing flavonoids that can be added in the daily diet of AD patients to enhance acetylcholine and reduce neuronal inflammation in the brain.
C1 [Kothawade, Sakshi M.; Kaur, Ginpreet] SVKMs NMIMS, Shobhaben Pratapbhai Patel Sch Pharm & Technol Man, Mumbai 56, Maharashtra, India.
   [Buttar, Harpal Singh] Univ Ottawa, Fac Med, Dept Pathol & Lab Med, Ottawa, ON, Canada.
   [Tuli, Hardeep Singh] Maharishi Markandeshwar Deemed Univ, Maharishi Markandeshwar Engn Coll, Dept Biotechnol, Mullana, Haryana, India.
C3 SVKM's NMIMS (Deemed to be University); University of Ottawa
RP Kaur, G (corresponding author), SVKMs NMIMS, Shobhaben Pratapbhai Patel Sch Pharm & Technol Man, Mumbai 56, Maharashtra, India.
EM ginpreet.aneja@gmail.com
RI kaur, Ginpreet/K-2325-2015; Tuli, Hardeep/ABA-9917-2021
OI Kaur, Ginpreet/0000-0002-5151-914X
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Z9 6
U1 1
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PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0028-1298
EI 1432-1912
J9 N-S ARCH PHARMACOL
JI Naunyn-Schmiedebergs Arch. Pharmacol.
PD NOV
PY 2023
VL 396
IS 11
BP 2813
EP 2830
DI 10.1007/s00210-023-02529-y
EA MAY 2023
PG 18
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA U1HD3
UT WOS:000994776600004
PM 37231172
DA 2025-06-11
ER

PT J
AU Sukkar, SG
   Traverso, N
   Furfaro, AL
   Tasso, B
   Marengo, B
   Domenicotti, C
   Pisciotta, L
   Pasta, A
   Marinari, UM
   Pronzato, MA
   Cottalasso, D
AF Sukkar, S. G.
   Traverso, N.
   Furfaro, A. L.
   Tasso, B.
   Marengo, B.
   Domenicotti, C.
   Pisciotta, L.
   Pasta, A.
   Marinari, U. M.
   Pronzato, M. A.
   Cottalasso, D.
TI Whey proteins inhibit food intake and tend to improve oxidative balance
   in obese zucker rats
SO EATING AND WEIGHT DISORDERS-STUDIES ON ANOREXIA BULIMIA AND OBESITY
LA English
DT Article
DE Body weight; Obesity; HNE; Glutathione; Appetite; Whey protein; Food
   intake; Oxidative stress
ID LIPID-PEROXIDATION; BODY-COMPOSITION; WEIGHT-GAIN; SUPPLEMENTATION;
   PERFORMANCE; FAT; RESTRICTION; GLUTATHIONE; METABOLITES; PRODUCT
AB Background/Aims Whey proteins (WP), obtained from milk after casein precipitation, represent a heterogeneous group of proteins. WP are reported to inhibit food intake in diet-induced experimental obesity; WP have been proposed as adjuvant therapy in oxidative stress-correlated pathologies. This work evaluates the effects of WP in comparison with casein, as a source of alimentary proteins, on food intake, weight growth and some indexes of oxidative equilibrium in Zucker Rats, genetically prone to obesity.
   Methods We monitored food intake and weight of Zucker Rats during the experiment, and some markers of oxidative equilibrium.
   Results WP induced significant decrease of food intake in comparison to casein (WP 80.41 +/- 1.069 ml/day; CAS: 88.95 +/- 1.084 ml/day; p < 0.0005). Body weight growth was slightly reduced, and the difference was just significant (WP 128.2 +/- 6.56 g/day; CAS 145.2 +/- 3.29 g/day; p = 0.049), while plasma HNE level was significantly lower in WP than in CAS (WP 41.2 +/- 6.3 vs CAS 69.61 +/- 4.69 pmol/ml, p = 0.007). Mild amelioration of oxidative equilibrium was indicated by a slight increase of total glutathione both in the liver and in the blood and a significant decrease of plasma 4-hydroxynonenal in the group receiving WP.
   Conclusions The effect of WP on food intake and weight growth in Zucker Rats is particularly noteworthy since the nature of their predisposition to obesity is genetic; the possible parallel amelioration of the oxidative balance may constitute a further advantage of WP since oxidative stress is believed to be interwoven to obesity, metabolic syndrome and their complications.
C1 [Traverso, N.; Furfaro, A. L.; Marengo, B.; Domenicotti, C.; Marinari, U. M.; Pronzato, M. A.; Cottalasso, D.] Univ Genoa, Gen Pathol Sect, DIMES, Genoa, Italy.
   [Sukkar, S. G.; Pisciotta, L.] IRCCS Osped Policlin San Martino Genova, Dietet & Nutr Unit, Largo R Benzi 2, I-16132 Genoa, Italy.
   [Tasso, B.] Univ Genoa, DISCIFAR, Genoa, Italy.
   [Pisciotta, L.; Pasta, A.] Univ Genoa, Dept Internal Med & Med Specialties, DIMI, Genoa, Italy.
C3 University of Genoa; University of Genoa; IRCCS AOU San Martino IST;
   University of Genoa; University of Genoa
RP Sukkar, SG (corresponding author), IRCCS Osped Policlin San Martino Genova, Dietet & Nutr Unit, Largo R Benzi 2, I-16132 Genoa, Italy.
EM Samir.sukkar@hsanmartino.it
RI Marengo, Barbara/U-3934-2019; Pasta, Andrea/AAX-3013-2021; Passalacqua,
   Mario/W-1973-2019; sukkar, samir/AAB-1850-2021; Pisciotta,
   Livia/K-4378-2018
OI sukkar, samir giuseppe/0000-0003-4194-1547; Pasta,
   Andrea/0000-0003-1791-4506
FU Difass International srlPrato (PO) (Italy)
FX This study has been supported by Difass International srlPrato (PO)
   (Italy). The Difass International srl-Prato (PO) (Italy) has provided us
   with Prother (R), (ultrafiltrated, undenaturated whey proteins formula)
   and with research supports and has participated in the design of the
   study; however, collection and analysis of data have been made by the
   authors independently from Difass International srl.
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NR 37
TC 2
Z9 2
U1 1
U2 4
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1124-4909
EI 1590-1262
J9 EAT WEIGHT DISORD-ST
JI Eat. Weight Disord.-Stud. Anorex.
PD DEC
PY 2021
VL 26
IS 8
BP 2453
EP 2461
DI 10.1007/s40519-020-01100-5
EA JAN 2021
PG 9
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychiatry
GA XA1RX
UT WOS:000606729100002
PM 33426629
DA 2025-06-11
ER

PT J
AU Cisternas, P
   Lindsay, CB
   Salazar, P
   Silva-Alvarez, C
   Retamales, RM
   Serrano, FG
   Vio, CP
   Inestrosa, NC
AF Cisternas, Pedro
   Lindsay, Carolina B.
   Salazar, Paulina
   Silva-Alvarez, Carmen
   Retamales, Rocio M.
   Serrano, Felipe G.
   Vio, Carlos P.
   Inestrosa, Nibaldo C.
TI The increased potassium intake improves cognitive performance and
   attenuates histopathological markers in a model of Alzheimer's disease
SO BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
LA English
DT Article
DE Alzheimer's disease; Potassium intake; Hypertension; Synaptic
   dysfunction
ID AMYLOID-BETA-PEPTIDE; OXIDATIVE STRESS; A-BETA; PHOSPHORYLATED TAU;
   MOUSE MODEL; MONOCLONAL-ANTIBODIES; SERUM INTERLEUKIN-6;
   LIPID-PEROXIDATION; METABOLIC SYNDROME; WATER-MAZE
AB Alzheimer's disease (AD) is a neurodegenerative disorder characterized by hallmarks that include an accumulation of amyloid-beta peptide (A beta), inflammation, oxidative stress and synaptic dysfunction, which lead to a decrease in cognitive function. To date, the onset and progression of AD have been associated with pathologies such as hypertension and diabetes. Hypertension, a disease with a high incidence worldwide, is characterized by a chronic increase in blood pressure. Interestingly, this disease has a close relationship to the eating behavior of patients because high Na+ intake is a significant risk factor for hypertension. In fact, a decrease in Na+ consumption, along with an increase in K+ intake, is a primary non-pharmacological approach to preventing hypertension. In the present work, we examined whether an increase in K+ intake affects the expression of certain neuropathological markers or the cognitive performance of a murine model of AD. We observed that an increase in K+ intake leads to a change in the aggregation pattern of the A beta peptide, a partial decrease in some epitopes of tau phosphorylation and improvement in the cognitive performance. The recovery in cognitive performance was correlated with a significant improvement in the generation of long-term potentiation. We also observed a decrease in markers related to inflammation and oxidative stress such as glial fibrillary acidic protein (GFAP), interleukin 6 (IL-6) and 4-hydroxynonenal (4-HNE). Together, our data support the idea that changes in diet, such as an increase in K+ intake, may be important in the prevention of AD onset as a non-pharmacological therapy. (C) 2015 Elsevier B.V. All rights reserved.
C1 [Cisternas, Pedro; Lindsay, Carolina B.; Salazar, Paulina; Silva-Alvarez, Carmen; Retamales, Rocio M.; Serrano, Felipe G.; Inestrosa, Nibaldo C.] Pontificia Univ Catolica Chile, Ctr Envejecimiento & Regenerat CARE, Dept Biol Celular, Fac Ciencias Biol, Santiago, Chile.
   [Vio, Carlos P.] Pontificia Univ Catolica Chile, Dept Fisiol, Fac Ciencias Biol, Santiago, Chile.
   [Inestrosa, Nibaldo C.] Univ New S Wales, Fac Med, Ctr Hlth Brain Ageing, Sch Psychiat, Sydney, NSW, Australia.
   [Inestrosa, Nibaldo C.] Pontificia Univ Catolica Chile, Ctr UC Sindrome Down, Santiago, Chile.
   [Inestrosa, Nibaldo C.] Univ Magallanes, Ctr Excelencia Biomed Magallanes CEBIMA, Punta Arenas, Chile.
C3 Pontificia Universidad Catolica de Chile; Pontificia Universidad
   Catolica de Chile; University of New South Wales Sydney; Pontificia
   Universidad Catolica de Chile; Universidad de Magallanes
RP Inestrosa, NC (corresponding author), Pontificia Univ Catolica Chile, CARE Biomed Res Ctr, Fac Biol Sci, Alameda 340,POB 114-D, Santiago, Chile.
EM ninestrosa@bio.puc.cl
RI Lindsay, Carolina/LXW-6683-2024; Vio, Carlos/JAX-7281-2023
OI CISTERNAS, PEDRO/0000-0001-7796-8982; Serrano,
   Felipe/0000-0003-1362-8561; Vio, Carlos/0000-0003-1850-5958;
   Retamales-Ortega, Rocio/0000-0002-9988-0356
FU Basal Center of Excellence in Aging and Regeneration [CONICYT-PFB
   12/2007]; FONDECYT [1120156, 11130529, 1130747, 3150475]; Sociedad
   Quimica y Minera de Chile (SQM)
FX This work was supported by grants from the Basal Center of Excellence in
   Aging and Regeneration (CONICYT-PFB 12/2007) to N.C.I. and C.P.V.,
   FONDECYT (no. 1120156) to N.C.I., FONDECYT (no. 11130529) to C.SA,
   FONDECYT (no. 1130747) to C.P.V. and postdoctoral fellowship from
   FONDECYT (no. 3150475) to P.C. We also thank to Sociedad Quimica y
   Minera de Chile (SQM) for special grants "The role of K<SUP>+</SUP> on
   hypertension and cognition" and "The role of lithium in human health and
   disease".
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NR 105
TC 27
Z9 27
U1 0
U2 36
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0925-4439
EI 1879-260X
J9 BBA-MOL BASIS DIS
JI Biochim. Biophys. Acta-Mol. Basis Dis.
PD DEC
PY 2015
VL 1852
IS 12
BP 2630
EP 2644
DI 10.1016/j.bbadis.2015.09.009
PG 15
WC Biochemistry & Molecular Biology; Biophysics; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Cell Biology
GA CU8XL
UT WOS:000363827300007
PM 26391254
OA Bronze
DA 2025-06-11
ER

PT J
AU Koren, S
   Shemesh-Bar, L
   Tirosh, A
   Peleg, RK
   Berman, S
   Abu Hamad, R
   Vinker, S
   Golik, A
   Efrati, S
AF Koren, Shlomit
   Shemesh-Bar, Lital
   Tirosh, Amit
   Peleg, Ronit Koren
   Berman, Sylvia
   Abu Hamad, Ramzia
   Vinker, Shlomo
   Golik, Ahuva
   Efrati, Shai
TI The Effect of Sitagliptin Versus Glibenclamide on Arterial Stiffness,
   Blood Pressure, Lipids, and Inflammation in Type 2 Diabetes Mellitus
   Patients
SO DIABETES TECHNOLOGY & THERAPEUTICS
LA English
DT Article
ID GLUCAGON-LIKE PEPTIDE-1; DIPEPTIDYL PEPTIDASE-4 INHIBITOR; GLYCEMIC
   CONTROL; CARDIOVASCULAR-DISEASE; ENDOTHELIAL FUNCTION; EXENATIDE
   EXENDIN-4; DOUBLE-BLIND; METABOLIC SYNDROME; TREATED PATIENTS;
   HEART-DISEASE
AB Aim: This study evaluated the effect of sitagliptin versus glibenclamide on arterial stiffness, blood pressure, lipid profile, oxidative stress, and high-sensitivity C-reactive protein (hsCRP) in type 2 diabetes mellitus patients.
   Subjects and Methods: Forty diabetes patients, inadequately controlled on metformin, were randomly assigned to either sitagliptin (100 mg/day) or glibenclamide (5 mg/day) for 3 months. Following a 1-month washout period, a crossover switch from glibenclamide to sitagliptin and vice versa was performed for an additional 3 months. Arterial stiffness, 24-h ambulatory blood pressure monitoring, lipids, hsCRP, glycated hemoglobin, fasting glucose, STAT-8-isoprostane (a measure of oxidative stress), body mass index (BMI), and waist circumference were measured at baseline and at 3 months with each of the study drugs.
   Results: Thirty-four patients completed the study. Glibenclamide had a better glucose-lowering effect than sitagliptin, but this was associated with more hypoglycemic events. BMI increased following glibenclamide treatment, whereas sitagliptin proved weight-neutral. Mean BMI gain was +0.5 +/- 1.0 kg/m(2) for glibenclamide versus -0.01 +/- 0.9 kg/m(2) for sitagliptin (P < 0.001). Triglyceride levels significantly dropped following sitagliptin, although they remained unaltered after glibenclamide treatment. Mean triglyceride decrease was -18.4 +/- 45 mg/mL after sitagliptin but -0.2 +/- 57 mg/dL following glibenclamide treatment (P = 0.018). There was no change in low-density lipoprotein, high-density lipoprotein, arterial stiffness, blood pressure monitoring, hsCRP, or STAT-8-isoprostane with each of the study drugs.
   Conclusions: Sitagliptin, but not glibenclamide, demonstrated a significant beneficial effect on BMI and triglyceride levels. However, arterial stiffness, blood pressure, oxidative stress, and inflammatory status were not significantly affected by adding sitagliptin or glibenclamide to metformin-treated type 2 diabetes patients.
C1 [Koren, Shlomit; Shemesh-Bar, Lital; Tirosh, Amit; Peleg, Ronit Koren; Golik, Ahuva] Assaf Harofeh Med Ctr, Dept Internal Med A, IL-70300 Zerifin, Israel.
   [Berman, Sylvia; Abu Hamad, Ramzia; Efrati, Shai] Assaf Harofeh Med Ctr, Res & Dev Unit, IL-70300 Zerifin, Israel.
   [Vinker, Shlomo] Tel Aviv Univ, Dept Family Med, Sackler Sch Med, IL-69978 Tel Aviv, Israel.
   [Vinker, Shlomo] Clalit Hlth Serv, Dept Family Med, Central Dist, Rishon Le Zion, Israel.
C3 Tel Aviv University; Shamir Medical Center (Assaf Harofeh); Shamir
   Medical Center (Assaf Harofeh); Tel Aviv University; Tel Aviv
   University; Sackler Faculty of Medicine; Clalit Health Services
RP Koren, S (corresponding author), Assaf Harofeh Med Ctr, Dept Internal Med, IL-70300 Zerifin, Israel.
EM shlomitks@gmail.com
RI vinker, Shlomo/HRC-3787-2023
OI Tirosh, Amit/0000-0003-3794-9634
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NR 43
TC 63
Z9 65
U1 0
U2 8
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1520-9156
EI 1557-8593
J9 DIABETES TECHNOL THE
JI Diabetes Technol. Ther.
PD JUL
PY 2012
VL 14
IS 7
BP 561
EP 567
DI 10.1089/dia.2011.0296
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 971ZF
UT WOS:000306245600004
PM 22512265
DA 2025-06-11
ER

PT J
AU Kamimura, N
   Nishimaki, K
   Ohsawa, I
   Ohta, S
AF Kamimura, Naomi
   Nishimaki, Kiyomi
   Ohsawa, Ikuroh
   Ohta, Shigeo
TI Molecular Hydrogen Improves Obesity and Diabetes by Inducing Hepatic
   FGF21 and Stimulating Energy Metabolism in db/db Mice
SO OBESITY
LA English
DT Article
ID ISCHEMIA-REPERFUSION INJURY; OXIDATIVE STRESS; PARKINSONS-DISEASE; RICH
   WATER; RAT MODEL; INHALATION; PREVENTS; ISCHEMIA/REPERFUSION;
   NEPHROPATHY; ANTIOXIDANT
AB Recent extensive studies have revealed that molecular hydrogen (H-2) has great potential for improving oxidative stress-related diseases by inhaling H-2 gas, injecting saline with dissolved H-2, or drinking water with dissolved H-2 (H-2-water); however, little is known about the dynamic movement of H-2 in a body. First, we show that hepatic glycogen accumulates H-2 after oral administration of H-2-water, explaining why consumption of even a small amount of H-2 over a short span time efficiently improves various disease models. This finding was supported by an in vitro experiment in which glycogen solution maintained H-2. Next, we examined the benefit of ad libitum drinking H-2-water to type 2 diabetes using db/db obesity model mice lacking the functional leptin receptor. Drinking H-2-water reduced hepatic oxidative stress, and significantly alleviated fatty liver in db/db mice as well as high fat-diet-induced fatty liver in wild-type mice. Long-term drinking H-2-water significantly controlled fat and body weights, despite no increase in consumption of diet and water. Moreover, drinking H-2-water decreased levels of plasma glucose, insulin, and triglyceride, the effect of which on hyperglycemia was similar to diet restriction. To examine how drinking H-2-water improves obesity and metabolic parameters at the molecular level, we examined gene-expression profiles, and found enhanced expression of a hepatic hormone, fibroblast growth factor 21 (FGF21), which functions to enhance fatty acid and glucose expenditure. Indeed, H-2 stimulated energy metabolism as measured by oxygen consumption. The present results suggest the potential benefit of H-2 in improving obesity, diabetes, and metabolic syndrome.
C1 [Kamimura, Naomi; Nishimaki, Kiyomi; Ohsawa, Ikuroh; Ohta, Shigeo] Nippon Med Sch, Grad Sch Med, Inst Dev & Aging Sci, Dept Biochem & Cell Biol, Kanagawa, Japan.
   [Ohsawa, Ikuroh] Tokyo Metropolitan Inst Gerontol, Dept Environm Gerontol, Itabashi Ku, Tokyo, Japan.
C3 Nippon Medical School; Tokyo Metropolitan Institute of Gerontology
RP Ohta, S (corresponding author), Nippon Med Sch, Grad Sch Med, Inst Dev & Aging Sci, Dept Biochem & Cell Biol, Kanagawa, Japan.
EM ohta@nms.ac.jp
RI Ohta, Shigeo/HKO-9826-2023
OI Ohta, Shigeo/0000-0002-2539-470X
FU Ministry of Education, Culture, Sports, Science and Technology of Japan
   [20300230, 20500723]; Ministry of Health, Labour and Welfare [20B-13];
   Grants-in-Aid for Scientific Research [23500971, 20300230, 20500723,
   23300257, 24651055, 22500680] Funding Source: KAKEN
FX We thank Blue Mercury (Tokyo, Japan) for the generous gift of hydrogen
   water and M. Takeda for technical assistance. This work was supported by
   a grant from the Ministry of Education, Culture, Sports, Science and
   Technology of Japan (No. 20300230 for S.O. and No. 20500723 for N.K.)
   and the Ministry of Health, Labour and Welfare for S.O. (Intramural
   Research Grant (20B-13) for Neurological and Psychiatric Disorders of
   NCNP).
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NR 33
TC 162
Z9 180
U1 1
U2 42
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1930-7381
EI 1930-739X
J9 OBESITY
JI Obesity
PD JUL
PY 2011
VL 19
IS 7
BP 1396
EP 1403
DI 10.1038/oby.2011.6
PG 8
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 784CU
UT WOS:000292132300012
PM 21293445
OA Bronze
DA 2025-06-11
ER

PT J
AU Pagano, F
   Picchio, V
   Bordin, A
   Cavarretta, E
   Nocella, C
   Cozzolino, C
   Floris, E
   Angelini, F
   Sordano, A
   Peruzzi, M
   Miraldi, F
   Biondi-Zoccai, G
   De Falco, E
   Carnevale, R
   Sciarretta, S
   Frati, G
   Chimenti, I
AF Pagano, Francesca
   Picchio, Vittorio
   Bordin, Antonella
   Cavarretta, Elena
   Nocella, Cristina
   Cozzolino, Claudia
   Floris, Erica
   Angelini, Francesco
   Sordano, Alessia
   Peruzzi, Mariangela
   Miraldi, Fabio
   Biondi-Zoccai, Giuseppe
   De Falco, Elena
   Carnevale, Roberto
   Sciarretta, Sebastiano
   Frati, Giacomo
   Chimenti, Isotta
TI Progressive stages of dysmetabolism are associated with impaired
   biological features of human cardiac stromal cells mediated by the
   oxidative state and autophagy
SO JOURNAL OF PATHOLOGY
LA English
DT Article
DE cardiac stromal cells; cardiac fibroblasts; autophagy; oxidative stress;
   cardiac fibrosis; metabolic syndrome; type 2 diabetes dmellitus;
   anti-fibrotic therapy
ID CARDIOSPHERE-DERIVED CELLS; HEART; HYPERGLYCEMIA; FIBROBLASTS;
   ACTIVATION; MECHANISMS; ENDOGLIN; PATHWAY
AB Cardiac stromal cells (CSCs) are the main players in fibrosis. Dysmetabolic conditions (metabolic syndrome-MetS, and type 2 diabetes mellitus-DM2) are strong pathogenetic contributors to cardiac fibrosis. Moreover, modulation of the oxidative state (OxSt) and autophagy is a fundamental function affecting the fibrotic commitment of CSCs, that are adversely modulated in MetS/DM2. We aimed to characterize CSCs from dysmetabolic patients, and to obtain a beneficial phenotypic setback from such fibrotic commitment by modulation of OxSt and autophagy. CSCs were isolated from 38 patients, stratified as MetS, DM2, or controls. Pharmacological modulation of OxSt and autophagy was obtained by treatment with trehalose and NOX4/NOX5 inhibitors (TREiNOX). Flow-cytometry and real-time quantitative polymerase chain reaction (RT-qPCR) analyses showed significantly increased expression of myofibroblasts markers in MetS-CSCs at baseline (GATA4, ACTA2, THY1/CD90) and after starvation (COL1A1, COL3A1). MetS- and DM2-CSCs displayed a paracrine profile distinct from control cells, as evidenced by screening of 30 secreted cytokines, with a significant reduction in vascular endothelial growth factor (VEGF) and endoglin confirmed by enzyme-linked immunoassay (ELISA). DM2-CSCs showed significantly reduced support for endothelial cells in angiogenic assays, and significantly increased H2O2 release and NOX4/5 expression levels. Autophagy impairment after starvation (reduced ATG7 and LC3-II proteins) was also detectable in DM2-CSCs. TREiNOX treatment significantly reduced ACTA2, COL1A1, COL3A1, and NOX4 expression in both DM2- and MetS-CSCs, as well as GATA4 and THY1/CD90 in DM2, all versus control cells. Moreover, TREiNOX significantly increased VEGF release by DM2-CSCs, and VEGF and endoglin release by both MetS- and DM2-CSCs, also recovering the angiogenic support to endothelial cells by DM2-CSCs. In conclusion, DM2 and MetS worsen microenvironmental conditioning by CSCs. Appropriate modulation of autophagy and OxSt in human CSCs appears to restore these features, mostly in DM2CSCs, suggesting a novel strategy against cardiac fibrosis in dysmetabolic patients. (c) 2022 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.
C1 [Pagano, Francesca] Natl Council Res IBBC CNR, Inst Biochem & Cell Biol, Monterotondo, Italy.
   [Picchio, Vittorio; Bordin, Antonella; Cavarretta, Elena; Cozzolino, Claudia; Floris, Erica; Angelini, Francesco; Sordano, Alessia; Biondi-Zoccai, Giuseppe; De Falco, Elena; Carnevale, Roberto; Sciarretta, Sebastiano; Frati, Giacomo; Chimenti, Isotta] Sapienza Univ, Dept Med Surg Sci & Biotechnol, Corso Repubbl 79, I-04100 Latina, Italy.
   [Cavarretta, Elena; Peruzzi, Mariangela; Biondi-Zoccai, Giuseppe; De Falco, Elena; Carnevale, Roberto; Chimenti, Isotta] Mediterranea Cardioctr, Naples, Italy.
   [Nocella, Cristina; Peruzzi, Mariangela; Miraldi, Fabio] Sapienza Univ, Dept Clin Internal Med Anesthesiol & Cardiovasc S, Rome, Italy.
   [Sciarretta, Sebastiano; Frati, Giacomo] IRCCS Neuromed, Dept AngioCardioNeurol, Pozzilli, Italy.
   [Picchio, Vittorio] Donawa Lifesci Consulting, Rome, Italy.
C3 Sapienza University Rome; Sapienza University Rome; IRCCS Neuromed
RP Chimenti, I (corresponding author), Sapienza Univ, Dept Med Surg Sci & Biotechnol, Corso Repubbl 79, I-04100 Latina, Italy.
EM isotta.chimenti@uniroma1.it
RI Nocella, Cristina/K-2175-2016; Frati, Giacomo/ABI-7410-2020; Peruzzi,
   Mariangela/AAG-5367-2019; Picchio, Vittorio/AAA-9661-2019; BORDIN,
   Antonella/AIC-6847-2022; Carnevale, Roberto/JMC-1138-2023; Chimenti,
   Isotta/D-2661-2015; Cavarretta, Elena/K-4468-2016; PICCHIO,
   VITTORIO/AAD-4697-2020; Pagano, Francesca/V-4204-2019; Biondi-Zoccai,
   Giuseppe/C-9670-2012
OI Chimenti, Isotta/0000-0002-0865-8814; Cavarretta,
   Elena/0000-0003-0221-6000; Peruzzi, Mariangela/0000-0002-9036-8495;
   PICCHIO, VITTORIO/0000-0003-1591-5118; Pagano,
   Francesca/0000-0003-1956-5864; Biondi-Zoccai,
   Giuseppe/0000-0001-6103-8510; angelini, francesco/0000-0002-0052-6956
FU Italian Health Ministry [2013-02355401]; Sapienza University
   [RG11916B85CDBF76, AR120172B8B543B3]; Regione Lazio [A0375-2020-36621]
FX The authors thank the funders of this work that was supported by: grant
   #GR-2013-02355401 from the Italian Health Ministry to SS and IC; grant
   #RG11916B85CDBF76 from Sapienza University to IC; grant
   #AR120172B8B543B3 from Sapienza University to VP. FP is supported by
   Grant #A0375-2020-36621 from Regione Lazio (POR-FESR 2014-2021).
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NR 60
TC 7
Z9 7
U1 2
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-3417
EI 1096-9896
J9 J PATHOL
JI J. Pathol.
PD OCT
PY 2022
VL 258
IS 2
BP 136
EP 148
DI 10.1002/path.5985
EA JUL 2022
PG 13
WC Oncology; Pathology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Pathology
GA 8E5GC
UT WOS:000832612100001
PM 35751644
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Ferreira, MR
   Alvarez, SM
   Illesca, P
   Giménez, MS
   Lombardo, YB
AF Ferreira, M. R.
   Alvarez, S. M.
   Illesca, P.
   Gimenez, M. S.
   Lombardo, Y. B.
TI Dietary Salba (Salvia hispanica L.) ameliorates the adipose
   tissue dysfunction of dyslipemic insulin-resistant rats through
   mechanisms involving oxidative stress, inflammatory cytokines and
   peroxisome proliferator-activated receptor γ
SO EUROPEAN JOURNAL OF NUTRITION
LA English
DT Article
DE alpha-linolenic acid (ALA); Adipose tissue; Dyslipidemia; High-sucrose
   diet; Oxidative stress; Insulin resistance
ID ALPHA-LINOLENIC ACID; POLYUNSATURATED FATTY-ACIDS; HIGH SUCROSE DIET;
   METABOLIC SYNDROME; CHIA SEED; 3T3-L1 ADIPOCYTES; LIPID-METABOLISM;
   SKELETAL-MUSCLE; RISK-FACTORS; RICH
AB Purpose Rats fed a long-term sucrose-rich diet (SRD) developed adipose tissue dysfunction. In the adipose tissue of these SRD-fed rats, the present study analyzed the possible beneficial effects of dietary Salba (chia) seeds in improving or reversing the depletion of antioxidant defenses, changes in pro-inflammatory cytokines and ROS production.
   Methods Wistar rats were fed a SRD for 3 months. After that, half of the animals continued with the SRD until month 6, while in the other half, corn oil was replaced by chia seeds for 3 months (SRD + chia). A reference group consumed a control diet all the time.
   Results Compared with the SRD-fed rats, the animals fed a SRD + chia showed a reduction in epididymal fat pad weight; the activities of antioxidant enzymes CAT, SOD and GPx returned to control values, while GR significantly improved; mRNA GPx increased, and both mRNA SOD and the redox state of glutathione returned to control values; a significant increase in the expression of Nrf2 was recorded. These results were accompanied by a decrease in XO activity and ROS contents as well as plasma IL-6 and TNF-alpha levels. Chia seeds reversed the decrease in PPAR gamma protein mass level and increased the n-3/n-6 fatty acids ratio of membrane phospholipids. Besides, dyslipidemia and insulin sensitivity were normalized.
   Conclusion This study provides new information concerning some mechanisms related to the beneficial effects of dietary chia seeds in reversing adipose tissue oxidative stress and improving the adipose tissue dysfunction induced by a SRD.
C1 [Ferreira, M. R.; Illesca, P.; Lombardo, Y. B.] Univ Nacl Litoral, Fac Bioquim, Dept Ciencias Biol, Ciudad Univ El Pozo CC 242, RA-3000 Santa Fe, Argentina.
   [Alvarez, S. M.; Gimenez, M. S.] Univ Nacl San Luis, Fac Quim Bioquim & Farm, Lab Biol Mol, Ave Ejercito Andes 950, RA-5700 San Luis, Argentina.
C3 National University of the Littoral; Universidad Nacional de San Luis
RP Lombardo, YB (corresponding author), Univ Nacl Litoral, Fac Bioquim, Dept Ciencias Biol, Ciudad Univ El Pozo CC 242, RA-3000 Santa Fe, Argentina.
EM ylombard@fbcb.unl.edu.ar
RI Alvarez, Silvina/GOE-5780-2022
OI Ferreira, Maria del Rosario/0000-0003-0760-9495; Alvarez,
   Silvina/0000-0001-7522-7208
FU Agencia Nacional de Promocion Cientifica y Tecnologica (ANPCYT) [PICT
   945 BID OC / AR 2011]; University of Litoral [CAI+D 0058 LI-2012]
FX The authors thank Dr. Carlos Marra INIBIOLP, Facultad de Ciencias
   Medicas, La Plata, Argentina for the evaluation of fatty acid
   composition of adipose tissue phospholipids. Thanks are also given to
   Silvia Rodriguez and Walter Da Ru for their skillful technical
   assistance. The present study was carried out with the financial support
   of Agencia Nacional de Promocion Cientifica y Tecnologica (ANPCYT)
   (Grant PICT 945 BID OC / AR 2011) and University of Litoral (CAI+D 0058
   LI-2012). The authors thank Agrisalba S.A, Buenos Aires, Argentina for
   providing the SALBA chia seeds.
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NR 47
TC 39
Z9 40
U1 0
U2 9
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1436-6207
EI 1436-6215
J9 EUR J NUTR
JI Eur. J. Nutr.
PD FEB
PY 2018
VL 57
IS 1
BP 83
EP 94
DI 10.1007/s00394-016-1299-5
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA FX0KU
UT WOS:000425733500006
PM 27566476
DA 2025-06-11
ER

PT J
AU Kim, HJ
   Joe, Y
   Kim, SK
   Park, SU
   Park, J
   Chen, Y
   Kim, J
   Ryu, J
   Cho, GJ
   Surh, YJ
   Ryter, SW
   Kim, UH
   Chung, HT
AF Kim, Hyo Jeong
   Joe, Yeonsoo
   Kim, Seul-Ki
   Park, Se-Ung
   Park, Jeongmin
   Chen, Yingqing
   Kim, Jin
   Ryu, Jinhyun
   Cho, Gyeong Jae
   Surh, Young-Joon
   Ryter, Stefan W.
   Kim, Uh-Hyun
   Chung, Hun-Taeg
TI Carbon monoxide protects against hepatic steatosis in mice by inducing
   sestrin-2 via the PERK-eIF2α-ATF4 pathway
SO FREE RADICAL BIOLOGY AND MEDICINE
LA English
DT Article
DE Autophagy; Carbon monoxide; Endoplasmic reticulum stress; Hepatic
   steatosis
ID FATTY LIVER-DISEASE; ENDOPLASMIC-RETICULUM-STRESS; HEME
   OXYGENASE-1/CARBON MONOXIDE; ENDOTHELIAL-CELL APOPTOSIS; KINASE PATHWAY;
   ISCHEMIA/REPERFUSION INJURY; MITOCHONDRIAL BIOGENESIS; ER STRESS;
   AUTOPHAGY; ACTIVATION
AB Nonalcoholic fatty liver disease (NAFLD), the hepatic manifestation of the metabolic syndrome, has emerged as one of the most common causes of chronic liver disease in developed countries over the last decade. NAFLD comprises a spectrum of pathological hepatic changes, including steatosis, steatohepatitis, advanced fibrosis, and cirrhosis. Autophagy, a homeostatic process for protein and organelle turnover, is decreased in the liver during the development of NAFLD. Previously, we have shown that carbon monoxide (CO), a reaction product of heme oxygenase (HO) activity, can confer protection in NAFLD, though the molecular mechanisms remain unclear. We therefore investigated the mechanisms underlying the protective effect of CO on methionine/choline-deficient (MCD) diet-induced hepatic steatosis. We found that CO induced sestrin-2 (SESN2) expression through enhanced mitochondrial ROS production and protected against MCD-induced NAFLD progression through activation of autophagy. SESN2 expression was increased by CO or CO-releasing molecule (CORM2), in a manner dependent on signaling through the protein kinase R-like endoplasmic reticulum kinase (PERK), eukaryotic initiation factor-2 alpha (eIF2 alpha)/activating transcription factor-4 (ATF4)-dependent pathway. CO-induced SESN2 upregulation in hepatocytes contributed to autophagy induction through activation of 5'-AMP-activated protein kinase (AMPK) and inhibition of mechanistic target of rapamycin (mTOR) complex I (mTORC1). Furthermore, we demonstrate that CO significantly induced the expression of SESN2 and enhanced autophagy in the livers of MCD-fed mice or in MCD-media treated hepatocytes. Conversely, knockdown of SESN2 abrogated autophagy activation and mTOR inhibition in response to CO. We conclude that CO ameliorates hepatic steatosis through the autophagy pathway induced by SESN2 upregulation.
C1 [Kim, Hyo Jeong; Joe, Yeonsoo; Kim, Seul-Ki; Park, Se-Ung; Park, Jeongmin; Chen, Yingqing; Kim, Jin; Chung, Hun-Taeg] Univ Ulsan, Dept Biol Sci, Ulsan 680749, South Korea.
   [Ryu, Jinhyun; Cho, Gyeong Jae] Gyeongsang Natl Univ, Sch Med, Dept Anat, Jinju 660701, South Korea.
   [Ryu, Jinhyun; Cho, Gyeong Jae] Gyeongsang Natl Univ, Inst Hlth Sci, Jinju 660701, South Korea.
   [Surh, Young-Joon] Seoul Natl Univ, Coll Pharm, Tumor Microenvironm Global Core Res Ctr, Seoul, South Korea.
   [Surh, Young-Joon] Seoul Natl Univ, Coll Pharm, Res Inst Pharmaceut Sci, Seoul, South Korea.
   [Ryter, Stefan W.] Weill Cornell Med Ctr, Div Pulm & Crit Care Med, New York Presbyterian Hosp, Joan & Sanford I Weill Dept Med, New York, NY USA.
   [Kim, Uh-Hyun] Chonbuk Natl Univ, Med Sch, Natl Creat Res Lab Signaling Network Ca2, Jeonju, South Korea.
C3 University of Ulsan; Gyeongsang National University; Gyeongsang National
   University; Seoul National University (SNU); Seoul National University
   (SNU); Cornell University; Weill Cornell Medicine; Weill Cornell Medical
   Center; NewYork-Presbyterian Hospital; Jeonbuk National University
RP Chung, HT (corresponding author), Univ Ulsan, Dept Biol Sci, Ulsan 680749, South Korea.; Kim, UH (corresponding author), Chonbuk Natl Univ, Med Sch, Natl Creat Res Lab Signaling Network Ca2, Jeonju, South Korea.
EM uhkim@chonbuk.ac.kr; chung@ulsan.ac.kr
RI Kim, Yoon/J-2746-2012; Chen, Yingqing/AAH-1367-2020
OI Chen, Yingqing/0000-0003-2326-7587
FU Priority Research Centers Program through the National Research
   Foundation of Korea (NRF) - Ministry of Education [2014R1A6A1030318];
   Bio & Medical Technology Development Program of the NRF - Ministry of
   Science, ICT & Future Planning [2012M3A9C3048687, NRF-2012R1A3A2026453]
FX This work was supported by Priority Research Centers Program through the
   National Research Foundation of Korea (NRF) funded by the Ministry of
   Education (2014R1A6A1030318) and the Bio & Medical Technology
   Development Program of the NRF funded by the Ministry of Science, ICT &
   Future Planning (2012M3A9C3048687) to H.T.C., NRF-2012R1A3A2026453 to
   U.H.K.
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TC 90
Z9 95
U1 0
U2 12
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0891-5849
EI 1873-4596
J9 FREE RADICAL BIO MED
JI Free Radic. Biol. Med.
PD SEP
PY 2017
VL 110
BP 81
EP 91
DI 10.1016/j.freeradbiomed.2017.05.026
PG 11
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA FB3NK
UT WOS:000406049200009
PM 28578014
OA hybrid
DA 2025-06-11
ER

PT J
AU Long, EK
   Olson, DM
   Bernlohr, DA
AF Long, Eric K.
   Olson, Dalay M.
   Bernlohr, David A.
TI High-fat diet induces changes in adipose tissue
   trans-4-oxo-2-nonenal and trans-4-hydroxy-2-nonenal levels
   in a depot-specific manner
SO FREE RADICAL BIOLOGY AND MEDICINE
LA English
DT Article
DE Adipose; Obesity; Oxidative stress; 4-HNE; 4-ONE; Gene expression; Free
   radicals
ID IONIZATION MASS-SPECTROMETRY; ACID-BINDING PROTEIN; LIPID-PEROXIDATION;
   OXIDATIVE STRESS; GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE; COVALENT
   MODIFICATION; INSULIN-RESISTANCE; METABOLIC SYNDROME; CROSS-LINKING;
   OBESITY
AB Protein carbonylation is the covalent modification of proteins by alpha,beta-unsaturated aldehydes produced by nonenzymatic lipid peroxidation of polyunsaturated fatty acids. The most widely studied aldehyde product of lipid peroxidation, trans-4-hydroxy-2-nonenal (4-HNE), is associated with obesity-induced metabolic dysfunction and has demonstrated reactivity toward key proteins involved in cellular function. However, 4-HNE is only one of many lipid peroxidation products and the lipid aldehyde profile in adipose tissue has not been characterized. To further understand the role of oxidative stress in obesity-induced metabolic dysfunction, a novel LC-MS/MS method was developed to evaluate aldehyde products of lipid peroxidation and applied to the analysis of adipose tissue. 4-HNE and trans-4-oxo-2-nonenal (4-ONE) were the most abundant aldehydes present in adipose tissue. In high fat-fed C57B1/6J and ob/ob mice the levels of lipid peroxidation products were increased 5- to 11-fold in epididymal adipose, unchanged in brown adipose, but decreased in subcutaneous adipose tissue. Epididymal adipose tissue of high fat-fed mice also exhibited increased levels of proteins modified by 4-HNE and 4-ONE, whereas subcutaneous adipose tissue levels of these modifications were decreased. High fat feeding of C57B1/6J mice resulted in decreased expression of a number of genes linked to antioxidant biology selectively in epididymal adipose tissue. Moreover, TNF alpha treatment of 3T3-L1 adipocytes resulted in decreased expression of GSTA4, GPx4, and Prdx3 while upregulating the expression of SOD2. These results suggest that inflammatory cytokines selectively downregulate antioxidant gene expression in visceral adipose tissue, resulting in elevated lipid aldehydes and increased protein carbonylation. (C) 2013 Elsevier Inc. All rights reserved.
C1 [Long, Eric K.; Olson, Dalay M.; Bernlohr, David A.] Univ Minnesota, Dept Biochem Mol Biol & Biophys, Minneapolis, MN 55455 USA.
   [Olson, Dalay M.] Univ Minnesota, Grad Program Integrat Biol & Physiol, Minneapolis, MN 55455 USA.
C3 University of Minnesota System; University of Minnesota Twin Cities;
   University of Minnesota System; University of Minnesota Twin Cities
RP Bernlohr, DA (corresponding author), Univ Minnesota, Dept Biochem Mol Biol & Biophys, Minneapolis, MN 55455 USA.
EM bernl001@umn.edu
FU NIH [DK084669, F32 DK091004]; Minnesota Obesity Center [NIH DK050456]
FX The authors thank the Minnesota Supercomputing Institute for
   computational and data storage support and the Minnesota Center for Mass
   Spectrometry and Proteomics for instrument usage. This work was funded
   by NIH DK084669 to D.A.B. and F32 DK091004 to E.K.L. and the Minnesota
   Obesity Center (NIH DK050456).
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NR 67
TC 61
Z9 72
U1 0
U2 50
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0891-5849
EI 1873-4596
J9 FREE RADICAL BIO MED
JI Free Radic. Biol. Med.
PD OCT
PY 2013
VL 63
SI SI
BP 390
EP 398
DI 10.1016/j.freeradbiomed.2013.05.030
PG 9
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 200TV
UT WOS:000323094700039
PM 23726997
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Collison, KS
   Saleh, SM
   Bakheet, RH
   Al-Rabiah, RK
   Inglis, AL
   Makhoul, NJ
   Maqbool, ZM
   Zaidi, MZ
   Al-Johi, MA
   Al-Mohanna, FA
AF Collison, Kate S.
   Saleh, Soad M.
   Bakheet, Razan H.
   Al-Rabiah, Rana K.
   Inglis, Angela L.
   Makhoul, Nadine J.
   Maqbool, Zakia M.
   Zaidi, Marya Zia
   Al-Johi, Mohammed A.
   Al-Mohanna, Futwan A.
TI Diabetes of the Liver: The Link Between Nonalcoholic Fatty Liver Disease
   and HFCS-55
SO OBESITY
LA English
DT Article
ID ENDOPLASMIC-RETICULUM STRESS; INDUCED INSULIN-RESISTANCE; FRUCTOSE CORN
   SYRUP; DIETARY FRUCTOSE; WEIGHT-GAIN; SERUM RETINOL-BINDING-PROTEIN-4;
   LIPOPROTEIN OVERPRODUCTION; MOLECULAR-MECHANISM; METABOLIC SYNDROME;
   OXIDATIVE STRESS
AB Nonalcoholic fatty liver disease (NAFLD) is associated with obesity and insulin resistance. It is also a predisposing factor for type 2 diabetes. Dietary factors are believed to contribute to all three diseases. NAFLD is characterized by increased intrahepatic fat and mitochondrial dysfunction, and its etiology may be attributed to excessive fructose intake. Consumption of high fructose corn syrup-55 (HFCS-55) stands at up to 15% of the average total daily energy intake in the United States, and is linked to weight gain and obesity. The aim of this study was to establish whether HFCS-55 could contribute to the pathogenesis of NAFLD, by examining the effects of HFCS-55 on hepatocyte lipogenesis, insulin signaling, and cellular function, in vitro and in vivo. Exposure of hepatocyles to HFCS-55 caused a significant increase in hepatocellular triglyceride (TG) and lipogenic proteins. Basal production of reactive oxygen metabolite (ROM) was increased, together with a decreased capacity to respond to an oxidative challenge. HFCS-55 induced a downregulation of the insulin signaling pathway, as indicated by attenuated (ser473)phosphorylation of AKT1. The c-Jun amino-terminal kinase (JNK), which is intimately linked to insulin resistance, was also activated; and this was accompanied by an increase in endoplasmic reticulum (ER) stress and intracellular free calcium perturbation. Hepatocytes exposed to HFCS-55 exhibited mitochondrial dysfunction and released cytochrome C (CytC) into the cytosol. Hepatic steatosis and mitochondrial disruption was induced in vivo by a diet enriched with 20% HFCS-55; accompanied by hypoadiponectinemia and elevated fasting serum insulin and retinol-binding protein-4 (RBP4) levels. Taken together our findings indicate a potential mechanism by which HFCS-55 may contribute to the pathogenesis of NAFLD.
C1 [Collison, Kate S.; Saleh, Soad M.; Bakheet, Razan H.; Al-Rabiah, Rana K.; Inglis, Angela L.; Makhoul, Nadine J.; Maqbool, Zakia M.; Zaidi, Marya Zia; Al-Johi, Mohammed A.; Al-Mohanna, Futwan A.] King Faisal Specialist Hosp & Res Ctr, Dept Biol & Med Res, Cell Biol & Diabet Res Unit, Riyadh 11211, Saudi Arabia.
C3 King Faisal Specialist Hospital & Research Center
RP Collison, KS (corresponding author), King Faisal Specialist Hosp & Res Ctr, Dept Biol & Med Res, Cell Biol & Diabet Res Unit, Riyadh 11211, Saudi Arabia.
RI Saleh, SOAD/KIB-4260-2024; Zaidi, Marya/JMR-2263-2023; Inglis,
   Angela/IXN-5890-2023
OI Bakheet, Razan/0009-0002-3534-181X; SALEH, SOAD/0009-0008-3368-3465;
   Makhoul, Nadine/0009-0006-6870-2262; Zaidi, Marya/0000-0002-0652-0184;
   Inglis, Angela/0009-0008-0756-2707
FU RAC [2070 006]
FX We thank Rhea Mondreal and Mohammed Al-Halaby for excellent technical
   assistance We also thank the staff of the Comparative Medicine
   Department, and our gratitude goes to Mr Hakim Al-Enazi for his
   unparalleled help in coordinating research resources. This work was
   supported by RAC project no 2070 006
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NR 71
TC 59
Z9 72
U1 0
U2 25
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1930-7381
EI 1930-739X
J9 OBESITY
JI Obesity
PD NOV
PY 2009
VL 17
IS 11
BP 2003
EP 2013
DI 10.1038/oby.2009.58
PG 11
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 512HT
UT WOS:000271237700008
PM 19282820
OA Bronze
DA 2025-06-11
ER

PT J
AU Reda, D
   Elshopakey, GE
   Albukhari, TA
   Almehmadi, SJ
   Refaat, B
   Risha, EF
   Mahgoub, HA
   El-Boshy, ME
   Abdelhamid, FM
AF Reda, Doha
   Elshopakey, Gehad E.
   Albukhari, Talat A.
   Almehmadi, Samah J.
   Refaat, Bassem
   Risha, Engy F.
   Mahgoub, Hebatallah A.
   El-Boshy, Mohamed E.
   Abdelhamid, Fatma M.
TI Vitamin D3 alleviates nonalcoholic fatty liver disease in rats by
   inhibiting hepatic oxidative stress and inflammation via the
   SREBP-1-c/PPARα-NF-κB/IR-S2 signaling pathway
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Article
DE hepatic steatosis; vitamin D; high-fat diet; insulin resistance;
   oxidative stress
ID METABOLIC SYNDROME; INSULIN-RESISTANCE; GENE-EXPRESSION; RISK-FACTORS;
   FRUCTOSE; NAFLD; OBESITY; SUPPLEMENTATION; STEATOHEPATITIS;
   ABNORMALITIES
AB Introduction: Nonalcoholic fatty liver disease (NAFLD) is a chronic disease characterized by fat deposits in liver cells, which can lead to hepatitis and fibrosis. This study attempted to explore the protective effect of vitamin D3 (VitD) against NAFLD.Methods: Adult male albino rats were randomized into four separate groups: the negative control group was fed a standard rat chow; the positive group received a high-fat diet (20%) and 25% fructose water (NAFLD); the VitD control group was intramuscularly treated with VitD (1,000 IU/kg BW) 3 days per week for 10 weeks; and the NAFLD group was treated with VitD therapy. Biochemical and hepatic histological analyses were performed. Hepatic oxidative stress and inflammatory conditions were also studied. Hepatic expression of sterol regulatory element-binding protein 1-c (SREBP-1-c), peroxisome proliferator-activated receptor alpha (PPAR-a), and insulin receptor substrate-2 was analyzed by quantitative real-time polymerase chain reaction.Results and discussion: The NAFLD rats exhibited elevated terminal body weight, hepatic injury markers, dyslipidemia, glucose intolerance, and insulin resistance. Moreover, the NAFLD rats had increased SREBP-1-c expression and reduced PPAR-a and IRS-2 expressions. Histological analysis showed hepatic steatosis and inflammation in the NAFLD group. In contrast, VitD administration improved the serum biochemical parameters and hepatic redox status in NAFLD rats. Also, VitD treatment ameliorated hepatic inflammation and steatosis in the NAFLD group by decreasing the expression of SREBP-1-c and increasing the expression of PPAR-a. Overall, these results suggest that VitD could have a protective effect against NAFLD and its associated complication.
C1 [Reda, Doha; Elshopakey, Gehad E.; Risha, Engy F.; El-Boshy, Mohamed E.; Abdelhamid, Fatma M.] Mansoura Univ, Fac Vet Med, Clin Pathol Dept, Mansoura, Egypt.
   [Albukhari, Talat A.] Umm Alqura Univ, Fac Med, Dept Haematol & Immunol, Mecca, Saudi Arabia.
   [Almehmadi, Samah J.; Refaat, Bassem] Umm Al Qura Univ, Fac Appl Med Sci, Lab Med Dept, Mecca, Saudi Arabia.
   [Mahgoub, Hebatallah A.] Mansoura Univ, Fac Vet Med, Pathol Dept, Mansoura, Egypt.
C3 Egyptian Knowledge Bank (EKB); Mansoura University; Umm Al-Qura
   University; Umm Al-Qura University; Egyptian Knowledge Bank (EKB);
   Mansoura University
RP Abdelhamid, FM (corresponding author), Mansoura Univ, Fac Vet Med, Clin Pathol Dept, Mansoura, Egypt.
EM may_mokh@mans.edu.eg
RI Refaat, Bassem/B-8836-2019; Elshopakey, Gehad/GQB-2109-2022; El-Boshy,
   Mohamed/N-2013-2018; Risha, Engy/L-7830-2018; Reda, Doha/GMX-1288-2022;
   M Abdelhamid, Fatma/AAA-9916-2020
OI M Abdelhamid, Fatma/0000-0003-0256-6828; Mahgoub, H.
   A./0000-0001-5832-9376
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NR 72
TC 20
Z9 21
U1 2
U2 11
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD MAY 16
PY 2023
VL 14
AR 1164512
DI 10.3389/fphar.2023.1164512
PG 13
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA I1IO7
UT WOS:001000385900001
PM 37261280
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Fuentes-Venado, CE
   Terán-Pérez, G
   Espinosa-Hernández, VM
   Martínez-Herrera, E
   Segura-Uribe, JJ
   Mercadillo, RE
   Pinto-Almazán, R
   Guerra-Araiza, C
AF Fuentes-Venado, Claudia Erika
   Teran-Perez, Guadalupe
   Espinosa-Hernandez, Victor Manuel
   Martinez-Herrera, Erick
   Segura-Uribe, Julia J.
   Mercadillo, Roberto E.
   Pinto-Almazan, Rodolfo
   Guerra-Araiza, Christian
TI Nutritional Status Influences Oxidative Stress and Insulin Resistance in
   Preschool Children
SO METABOLIC SYNDROME AND RELATED DISORDERS
LA English
DT Article
DE malnutrition; obesity; overweight; underweight; oxidative stress;
   children; insulin resistance
ID TRIGLYCERIDE-GLUCOSE INDEX; OBESE CHILDREN; METABOLIC SYNDROME;
   ANTIOXIDANT CAPACITY; NORMAL-WEIGHT; ADOLESCENTS; MALNUTRITION;
   OVERWEIGHT; INDICATOR; MARKERS
AB Background: Child malnutrition represents a major public health problem with physiological, psychological, and social short- and long-term implications. Objective: To compare the influence of nutritional status on oxidative stress (OS) markers in children aged 3-6 years. Methods: Children were categorized into four groups: underweight, normal weight, overweight, and obesity. Glucose (Glu), cholesterol (Chol), high-density lipoproteins, insulin, triacylglycerols (TG), triacylglycerols/glucose (TyG) index, and the homeostasis model assessment of insulin resistance (HOMA-IR) were analyzed. In addition, OS [malondialdehyde (MDA) and 3-nitrotyrosine (3-NT)] and antioxidant defense markers [superoxide dismutase (SOD), catalase (CAT), and the ratio of reduced/oxidized glutathione (GSH/GSSG)] were quantified. Results: Children with obesity showed significantly higher levels of MDA and 3-NT, and increased SOD activity compared with normal weight children. Glu, Chol, TG levels, TyG indexes, HOMA-IR, MDA, 3-NT, and SOD positively correlated with body mass index (BMI) and Centers for Disease Control and Prevention percentiles (CDC PC). However, CAT concentration and the GSH/GSSG ratio correlated negatively with BMI and CDC PC. In children with underweight, we found a positive correlation of TG levels and TyG indexes with BMI, whereas both markers positively correlated with BMI and CDC PC in children with overweight. MDA negatively correlated with BMI in children with underweight, while a positive association was observed in children with overweight. Finally, SOD, CAT, and GSH/GSSG negatively correlated with both BMI and CDC PC in children with overweight. Conclusions: Malnutrition, especially obesity, is associated with metabolic and OS disturbances in preschool children. It is urgent to design strategies to prevent malnutrition in this age group since this stage of development is crucial to potentially avoid future co-morbidities.
C1 [Fuentes-Venado, Claudia Erika] Univ Autonoma Metropolitana, Ciencias Biol & Salud, Mexico City, DF, Mexico.
   [Fuentes-Venado, Claudia Erika; Guerra-Araiza, Christian] Hosp Gen Zona 197, Serv Med Fis & Rehabil, Texcoco, Mexico.
   [Fuentes-Venado, Claudia Erika] Inst Mexicano Seguro Social, Ctr Med Nacl Siglo XXI, Hosp Especialidades, Unidad Invest Med Farmacol, Ave Cuauhtemoc 330, Mexico City 06720, DF, Mexico.
   [Teran-Perez, Guadalupe] Univ Autonoma Metropolitana Iztapalapa, Clin Trastornos Sueno, Mexico City, DF, Mexico.
   [Espinosa-Hernandez, Victor Manuel] Inst Politecn Nacl, Escuela Super Med, Ciencias Salud, Mexico City, DF, Mexico.
   [Espinosa-Hernandez, Victor Manuel; Martinez-Herrera, Erick; Pinto-Almazan, Rodolfo] Hosp Reg Alta Especialidad Ixtapaluca, Unidad Invest, Carretera Fed Mexico Puebla Km 34-5, Ixtapaluca 56530, State Of Mexico, Mexico.
   [Martinez-Herrera, Erick; Pinto-Almazan, Rodolfo] Inst Politecn Nacl, Escuela Super Med, Seccio Estudios Posgrad & Invest, Mexico City, DF, Mexico.
   [Segura-Uribe, Julia J.] Hosp Infantil Mexico Dr Federico Gomez, Secretaria Salud, Subdirecc Gest Invest, Mexico City, DF, Mexico.
   [Mercadillo, Roberto E.] Consejo Nacl Ciencia & Technol, Mexico City, DF, Mexico.
   [Mercadillo, Roberto E.] Univ Autonoma Metropolitana Iztapalapa, Dept Biol Reprod, Mexico City, DF, Mexico.
C3 Universidad Autonoma Metropolitana - Mexico; Instituto Mexicano del
   Seguro Social; Instituto Mexicano del Seguro Social; Universidad
   Autonoma Metropolitana - Mexico; Instituto Politecnico Nacional -
   Mexico; Instituto Politecnico Nacional - Mexico; Hospital Infantil de
   Mexico Federico Gomez; Consejo Nacional de Ciencia y Tecnologia
   (CONACyT); Universidad Autonoma Metropolitana - Mexico
RP Guerra-Araiza, C (corresponding author), Inst Mexicano Seguro Social, Ctr Med Nacl Siglo XXI, Hosp Especialidades, Unidad Invest Med Farmacol, Ave Cuauhtemoc 330, Mexico City 06720, DF, Mexico.; Pinto-Almazán, R (corresponding author), Hosp Reg Alta Especialidad Ixtapaluca, Unidad Invest, Carretera Fed Mexico Puebla Km 34-5, Ixtapaluca 56530, State Of Mexico, Mexico.
EM christianguerra2001@gmail.com
RI Martínez-Herrera, Erick/AEW-5266-2022; Segura-Uribe,
   Julia/AAD-7192-2020; Pinto-Almazan, Rodolfo/F-3483-2013; Segura-Uribe,
   Julia J./G-7011-2017
OI Pinto-Almazan, Rodolfo/0000-0002-5210-5395; Segura-Uribe, Julia
   J./0000-0002-0676-5667
FU CIS/IMSS/scholarships; Hospital General de Zona [197 IMSS]; Hospital
   Regional de Alta Especialidad de Ixtapaluca; Universidad del Valle de
   Mexico Campus Texcoco; municipality of Chiconcuac, Estado de Mexico;
   CONACyT [429750]
FX This work was submitted in partial fulfillment of the requirements for
   the PhD degree of Claudia Erika FuentesVenado at the Doctorado en
   Ciencias Biologicas y de la Salud Program (Universidad Autonoma
   Metropolitana). Claudia Erika Fuentes-Venado received financial support
   from CONACyT (429750) and CIS/IMSS/scholarships.The authors would like
   to thank the municipality of Chiconcuac, Estado de Mexico, especially
   Dr. Georgina Castillo Galvez; the Hospital General de Zona No. 197 IMSS,
   especially to Dr. Alfonso Cruz Hernandez; the Hospital Regional de Alta
   Especialidad de Ixtapaluca, especially to Dr. Heberto Arboleya Casanova;
   and the Universidad del Valle de Mexico Campus Texcoco for the support
   provided to conduct this study.
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NR 76
TC 9
Z9 9
U1 0
U2 8
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-4196
EI 1557-8518
J9 METAB SYNDR RELAT D
JI Metab. Syndr. Relat. Disord.
PD NOV 1
PY 2021
VL 19
IS 9
BP 513
EP 523
DI 10.1089/met.2021.0021
EA JUL 2021
PG 11
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA WV6IJ
UT WOS:000677827100001
PM 34314624
DA 2025-06-11
ER

PT J
AU Sparrow, RL
AF Sparrow, Rosemary L.
TI Red blood cell components: time to revisit the sources of variability
SO BLOOD TRANSFUSION
LA English
DT Review
DE blood donor; component processing; red blood cells; transfusion
ID OXIDATIVE STRESS; IN-VITRO; WHOLE-BLOOD;
   GLUCOSE-6-PHOSPHATE-DEHYDROGENASE DEFICIENCY; ERYTHROCYTE-MEMBRANES;
   DONOR CHARACTERISTICS; ANTIOXIDANT CAPACITY; INTERNATIONAL FORUM;
   RECIPIENT SURVIVAL; METABOLIC SYNDROME
AB Quality and safety of red blood cell (RBC) components is managed by screening of donors and strict regulatory controls of blood collection, processing and storage procedures. Despite these efforts, variations in RBC component quality exist as exemplified by the wide range in storage-induced haemolysis. This article provides a brief overview of the variables that contribute or potentially contribute to the quality of stored RBC components, including blood collection, processing, and donor-related variables. Particular focus is made on donor health and lifestyle factors that are not specifically screened and may impact on the physicobiochemical properties of RBCs and their storability. Inflammatory and oxidative stress states may be especially relevant as RBCs are susceptible to oxidative injury. Few studies have investigated the effect of specific donor-related variables on the quality of stored RBC components. Donor-related variables may be unaccounted confounders in the "age of blood" clinical studies that compared outcomes following transfusion of fresher or longer-stored RBC components. The conclusion is drawn that the blood donor is the greatest source of RBC component variability and the least "regulated" aspect of blood component production. It is proposed that more research is needed to better understand the connection between donor-related variables and quality consistency of stored RBC components. This could be very important given the impact of modern lifestyles that sees escalating rates of non-communicable health conditions that are associated with increased oxidative stress, such as hypertension, obesity and diabetes in children and adults, as well as an ageing population in many countries. The effect of these changes to global health and population demographics will impact on blood donor panels, and without significant new research, the consequences on the quality of stored blood components and transfusion outcomes are unknown.
C1 [Sparrow, Rosemary L.] Monash Univ, Dept Pathol & Immunol, Melbourne, Vic, Australia.
C3 Monash University
RP Sparrow, RL (corresponding author), Monash Univ, Dept Immunol, AMREP, 89 Commercial Rd, Melbourne, Vic 3004, Australia.
EM rosemary.sparrow@monash.edu
OI Sparrow, Rosemary/0000-0002-6689-2983
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NR 104
TC 40
Z9 40
U1 0
U2 14
PU SIMTIPRO SRL
PI MILAN
PA VIA DESIDERIO 21, MILAN, 20131, ITALY
SN 1723-2007
J9 BLOOD TRANSFUS-ITALY
JI Blood Transf.
PY 2017
VL 15
IS 2
BP 116
EP 125
DI 10.2450/2017.0326-16
PG 10
WC Hematology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Hematology
GA EM7QP
UT WOS:000395507700005
PM 28263168
DA 2025-06-11
ER

PT J
AU Fernández-Real, JM
   García-Fuentes, E
   Moreno-Navarrete, JM
   Murri-Pierri, M
   Garrido-Sánchez, L
   Ricart, W
   Tinahones, F
AF Fernandez-Real, Jose M.
   Garcia-Fuentes, Eduardo
   Moreno-Navarrete, Jose M.
   Murri-Pierri, Mora
   Garrido-Sanchez, Lourdes
   Ricart, Wifredo
   Tinahones, Francisco
TI Fat Overload Induces Changes in Circulating Lactoferrin That Are
   Associated With Postprandial Lipemia and Oxidative Stress in Severely
   Obese Subjects
SO OBESITY
LA English
DT Article
ID BLOOD MONONUCLEAR-CELLS; FACTOR-KAPPA-B; ENDOTHELIAL FUNCTION;
   HEALTHY-VOLUNTEERS; METABOLIC SYNDROME; DIABETES-MELLITUS; OLIVE OIL;
   RAT-LIVER; PLASMA; ACTIVATION
AB Lactoferrin is an innate immune system protein with anti-inflammatory and antioxidant activities. We aimed to evaluate circulating lactoferrin levels in association with lipid concentrations, and parameters of oxidative stress and inflammation in subjects with morbid obesity after an acute fat intake. The effects of a 60 g fat overload on circulating lactoferrin and antioxidant activities were evaluated in 45 severely obese patients (15 men and 30 women, BMI 53.4 +/- 7.2 kg/m(2)). The change in circulating lactoferrin after fat overload was significantly and inversely associated with the free fatty acid (FFA) change. In those subjects with the highest increase in lactoferrin (in the highest quartile), high-density lipoprotein (HDL)-cholesterol decreased after fat overload to a lesser extent (P = 0.03). In parallel to lipid changes, circulating lactoferrin concentrations were inversely linked to the variations in catalase (CAT) and glutathione reductase (GSH-Rd). Baseline circulating lactoferrin concentration was also inversely associated with the absolute change in antioxidant activity after fat overload, and with the change in C-reactive protein (CRP). Furthermore, those subjects with higher than the median value of homeostasis model assessment of insulin secretion (HOMA(IS)) had significantly increased lactoferrin concentration after fat load (885 +/- 262 vs. 700 +/- 286 ng/ml, P = 0.03). Finally, we further explored the action of lactoferrin in vitro. Lactoferrin (10 mu mol/l) led to significantly lower triglyceride (TG) concentrations and lactate dehydrogenase activity (as expression of cell viability) in the media from adipose explants obtained from severely obese subjects. In conclusion, circulating lactoferrin concentrations, both at baseline and fat-stimulated, were inversely associated with postprandial lipemia, and parameters of oxidative stress and fat-induced inflammation in severely obese subjects.
C1 [Fernandez-Real, Jose M.; Moreno-Navarrete, Jose M.; Ricart, Wifredo] Inst Invest Biomed Girona, Dept Diabet Endocrinol & Nutr, Girona, Spain.
   [Fernandez-Real, Jose M.; Moreno-Navarrete, Jose M.; Ricart, Wifredo] Inst Salud Carlos III, Dept Obes & Nutr, CIBEROBN Fisiopatol Obesidad & Nutr CB06 03 010, Madrid, Spain.
   [Garcia-Fuentes, Eduardo; Murri-Pierri, Mora; Garrido-Sanchez, Lourdes; Tinahones, Francisco] Hosp Virgen Victoria Malaga, Dept Endocrinol & Nutr, Malaga, Spain.
   [Garcia-Fuentes, Eduardo; Murri-Pierri, Mora; Garrido-Sanchez, Lourdes; Tinahones, Francisco] Inst Salud Carlos III, Dept Obes & Nutr, CIBEROBN Fisiopatol Obesidad & Nutr CB06 03 018, Madrid, Spain.
C3 Universitat de Girona; Girona University Hospital Dr. Josep Trueta;
   Institut d'Investigacio Biomedica de Girona (IDIBGI); CIBER - Centro de
   Investigacion Biomedica en Red; CIBEROBN; Instituto de Salud Carlos III;
   Instituto de Salud Carlos III; CIBER - Centro de Investigacion Biomedica
   en Red; CIBEROBN
RP Fernández-Real, JM (corresponding author), Inst Invest Biomed Girona, Dept Diabet Endocrinol & Nutr, Girona, Spain.
EM jmfernandezreal.girona.ics@gencat.cat
RI Fernández-Real, Jose Manuel/AGH-3599-2022; Tinahones,
   Francisco/AAB-2882-2020; Garcia-Fuentes, Eduardo/AAB-1607-2020;
   Moreno-Navarrete, Jose Maria/H-9772-2015
OI Ricart, Wifredo/0000-0002-3452-9098; GARCIA-FUENTES,
   EDUARDO/0000-0002-3491-2724; Murri, Mora/0000-0002-6482-192X;
   Fernandez-Real, Jose Manuel/0000-0002-7442-9323; Tinahones, Francisco
   J/0000-0001-6871-4403; Moreno-Navarrete, Jose Maria/0000-0002-2883-511X
FU CIBEROBN Fisiopatologia Obesidad y Nutricion [CB06/03/010]; Instituto de
   Salud Carlos III and CIBEROBN Fisiopatologia Obesidad y Nutricion
   [CB06/03/018]
FX This work was partially supported by CIBEROBN Fisiopatologia Obesidad y
   Nutricion (CB06/03/010), Instituto de Salud Carlos III and CIBEROBN
   Fisiopatologia Obesidad y Nutricion (CB06/03/018), Instituto de Salud
   Carlos III. We acknowledge the administrative help of Paula Otero. E.
   G.-F., M. M.-P., J. M. M.-N., and L. G.-S. collected and analyzed data.
   F. T., W. R., and J. M. F.-R. wrote the paper.
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TC 32
Z9 32
U1 0
U2 19
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 1930-7381
J9 OBESITY
JI Obesity
PD MAR
PY 2010
VL 18
IS 3
BP 482
EP 488
DI 10.1038/oby.2009.266
PG 7
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 562BO
UT WOS:000275024100009
PM 19696758
OA Bronze
DA 2025-06-11
ER

PT J
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   Nistor, C
   Carsote, M
AF Osman, Andrei
   Petrescu, Gabriel Sebastian
   Tuculina, Mihaela Jana
   Dascalu, Ionela Teodora
   Popescu, Cristina
   Enescu, Anca-Stefania
   Daguci, Constantin
   Cucu, Anca-Pati
   Nistor, Claudiu
   Carsote, Mara
TI Metabolic and Other Endocrine Elements with Regard to Lifestyle Choices:
   Focus on E-Cigarettes
SO METABOLITES
LA English
DT Review
DE lifestyle; metabolic; endocrine disorder; diabetes; obesity; metabolic
   syndrome; e-cigarettes; lung; vaping; steroid
ID ELECTRONIC-CIGARETTE; OXIDATIVE STRESS; REFILL LIQUID; SMOKING;
   EXPOSURE; IMPACT; YOUNG; MEN
AB Our objective was to overview recent data on metabolic/endocrine disorders with respect to e-cigarette (e-cig) use. This is a narrative review; we researched English, full-length, original articles on PubMed (between January 2020 and August 2023) by using different keywords in the area of metabolic/endocrine issues. We only included original clinical studies (n = 22) and excluded case reports and experimental studies. 3 studies (N1 = 22,385; N2 = 600,046; N3 = 5101) addressed prediabetes risk; N1 showed a 1.57-fold increased risk of dual vs. never smokers, a higher risk that was not confirmed in N2 (based on self-reported assessments). Current non-smokers (N1) who were dual smokers still have an increased odd of prediabetes (a 1.27-fold risk increase). N3 and another 2 studies addressed type 2 diabetes mellitus (DM): a lower prevalence of DM among dual users (3.3%) vs. cigarette smoking (5.9%) was identified. 6 studies investigated obesity profile (4 of them found positive correlations with e-cig use). One study (N4 = 373,781) showed that e-cig use was associated with obesity in the general population (OR = 1.6, 95%CI: 1.3-2.1, p < 0.05); another (N5 = 7505, 0.82% were e-cig-only) showed that obesity had a higher prevalence in dual smokers (51%) vs. cig-only (41.2%, p < 0.05), while another (N6 = 3055) found that female (not male) e-cig smokers had higher body mass index vs. non-smokers. Data on metabolic syndrome (MS) are provided for dual smokers (n = 2): one case-control study found that female dual smokers had higher odds of MS than non-smokers. The need for awareness with respect to potential e-cig--associated medical issues should be part of modern medicine, including daily anamnesis. Whether the metabolic/endocrine frame is part of the general picture is yet to be determined. Surveillance protocols should help clinicians to easily access the medical background of one subject, including this specific matter of e-cig with/without conventional cigarettes smoking and other habits/lifestyle elements, especially when taking into consideration metabolism anomalies.
C1 [Osman, Andrei; Popescu, Cristina; Enescu, Anca-Stefania] Univ Med & Pharm Craiova, Fac Dent Med, Dept Anat & Embryol, Dept ENT, Craiova 200349, Romania.
   [Osman, Andrei; Popescu, Cristina; Enescu, Anca-Stefania] Clin Emergency Cty Hosp Craiova, Craiova 200349, Romania.
   [Petrescu, Gabriel Sebastian] Univ Med & Pharm Craiova, Fac Dent Med, Dept Oral & Maxillofacial Surg, Craiova 200349, Romania.
   [Tuculina, Mihaela Jana] Univ Med & Pharm Craiova, Fac Dent Med, Dept Endodont, Craiova 200349, Romania.
   [Dascalu, Ionela Teodora] Univ Med & Pharm Craiova, Fac Dent Med, Dept Orthodont, Craiova 200349, Romania.
   [Daguci, Constantin] Univ Med & Pharm Craiova, Fac Dent Med, Dept Oro Dent Prevent, Craiova 200349, Romania.
   [Cucu, Anca-Pati] Carol Davila Univ Med & Pharm, Dr Carol Davila Cent Mil Emergency Univ Hosp, PhD Doctoral Sch, Bucharest & Thorac Surg Dept, Bucharest 010825, Romania.
   [Nistor, Claudiu] Carol Davila Univ Med & Pharm, Dr Carol Davila Cent Mil Emergency Univ Hosp, Dept Cardiothorac Pathol 4, Thorac Surg Discipline 2, Bucharest 010825, Romania.
   [Nistor, Claudiu] Dr Carol Davila Cent Mil Emergency Univ Hosp, Thorac Surg Dept, Bucharest 010825, Romania.
   [Carsote, Mara] Carol Davila Univ Med & Pharm, Dept Endocrinol, Bucharest, Romania.
   [Carsote, Mara] CI Parhon Natl Inst Endocrinol, Bucharest 011863, Romania.
C3 University of Medicine & Pharmacy of Craiova; University of Medicine &
   Pharmacy of Craiova; University of Medicine & Pharmacy of Craiova;
   University of Medicine & Pharmacy of Craiova; University of Medicine &
   Pharmacy of Craiova; Carol Davila University of Medicine & Pharmacy;
   Carol Davila University of Medicine & Pharmacy; Carol Davila University
   of Medicine & Pharmacy; National Institute of Endocrinology C.I. Parhon
RP Tuculina, MJ (corresponding author), Univ Med & Pharm Craiova, Fac Dent Med, Dept Endodont, Craiova 200349, Romania.; Dascalu, IT (corresponding author), Univ Med & Pharm Craiova, Fac Dent Med, Dept Orthodont, Craiova 200349, Romania.
EM andreiosman3@gmail.com; sebigabriel_petrescu@yahoo.com;
   mtuculina@yahoo.com; marceldascalu@yahoo.com;
   cristina.popescu25@yahoo.com; anca.stefania.enescu@gmail.com;
   dagucicristi@yahoo.com; ancutapati@gmail.com; ncd58@yahoo.com;
   carsote_m@hotmail.com
RI Petrescu, Gabriel/IQS-7395-2023; NISTOR, CLAUDIU EDUARD/ABA-3269-2021;
   Tuculina, Mihaela/B-2287-2015; Popescu, Cristina/ABH-3205-2020; CUCU,
   ANCA - PATI/AAE-3646-2022
OI Popescu, Cristina/0009-0001-6745-9823; CUCU, ANCA -
   PATI/0000-0003-0326-1145; Petrescu,
   Gabriel-Sebastian/0009-0001-5447-4936; Carsote,
   Mara/0000-0001-8585-3835; Nistor, Claudiu-Eduard/0000-0002-2274-5666;
   Tuculina, Mihaela/0000-0002-6535-3152
FU University of Medicine and Pharmacy of Craiova; Craiova, Romania
FX This paper was supported by University of Medicine and Pharmacy of
   Craiova, 200349 Craiova, Romania.
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NR 101
TC 29
Z9 29
U1 3
U2 5
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2218-1989
J9 METABOLITES
JI Metabolites
PD DEC
PY 2023
VL 13
IS 12
AR 1192
DI 10.3390/metabo13121192
PG 22
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA DM2B6
UT WOS:001132383900001
PM 38132874
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU van Drie, RWA
   van de Wouw, J
   Zandbergen, LM
   Dehairs, J
   Swinnen, JV
   Mulder, MT
   Verhaar, MC
   MaassenVandenbrink, A
   Duncker, DJ
   Sorop, O
   Merkus, D
AF van Drie, R. W. A.
   van de Wouw, J.
   Zandbergen, L. M.
   Dehairs, J.
   Swinnen, J. V.
   Mulder, M. T.
   Verhaar, M. C.
   MaassenVandenbrink, A.
   Duncker, D. J.
   Sorop, O.
   Merkus, D.
TI Vasodilator reactive oxygen species ameliorate perturbed myocardial
   oxygen delivery in exercising swine with multiple comorbidities
SO BASIC RESEARCH IN CARDIOLOGY
LA English
DT Article
DE Reactive oxygen species; Swine; Myocardial perfusion; Coronary
   microcirculation; Metabolic syndrome
ID PRESERVED EJECTION FRACTION; CORONARY-ARTERY-DISEASE; HYDROGEN-PEROXIDE;
   NITRIC-OXIDE; XANTHINE OXIDOREDUCTASE; OXIDATIVE STRESS; NEUTRAL
   SPHINGOMYELINASE-2; SUPEROXIDE-PRODUCTION; ARTERIOLAR DILATION;
   SEX-DIFFERENCES
AB Multiple common cardiovascular comorbidities produce coronary microvascular dysfunction. We previously observed in swine that a combination of diabetes mellitus (DM), high fat diet (HFD) and chronic kidney disease (CKD) induced systemic inflammation, increased oxidative stress and produced coronary endothelial dysfunction, altering control of coronary microvascular tone via loss of NO bioavailability, which was associated with an increase in circulating endothelin (ET). In the present study, we tested the hypotheses that (1) ROS scavenging and (2) ETA+B-receptor blockade improve myocardial oxygen delivery in the same female swine model. Healthy female swine on normal pig chow served as controls (Normal). Five months after induction of DM (streptozotocin, 3 x 50 mg kg-1 i.v.), hypercholesterolemia (HFD) and CKD (renal embolization), swine were chronically instrumented and studied at rest and during exercise. Sustained hyperglycemia, hypercholesterolemia and renal dysfunction were accompanied by systemic inflammation and oxidative stress. In vivo ROS scavenging (TEMPOL + MPG) reduced myocardial oxygen delivery in DM + HFD + CKD swine, suggestive of a vasodilator influence of endogenous ROS, while it had no effect in Normal swine. In vitro wire myography revealed a vasodilator role for hydrogen peroxide (H2O2) in isolated small coronary artery segments from DM + HFD + CKD, but not Normal swine. Increased catalase activity and ceramide production in left ventricular myocardial tissue of DM + HFD + CKD swine further suggest that increased H2O2 acts as vasodilator ROS in the coronary microvasculature. Despite elevated ET-1 plasma levels in DM + HFD + CKD swine, ETA+B blockade did not affect myocardial oxygen delivery in Normal or DM + HFD + CKD swine. In conclusion, loss of NO bioavailability due to 5 months exposure to multiple comorbidities is partially compensated by increased H2O2-mediated coronary vasodilation.
C1 [van Drie, R. W. A.; van de Wouw, J.; Zandbergen, L. M.; Duncker, D. J.; Sorop, O.; Merkus, D.] Erasmus MC, Dept Cardiol, Div Expt Cardiol, POB 2040, NL-3000 CA Rotterdam, Netherlands.
   [van Drie, R. W. A.; Mulder, M. T.; MaassenVandenbrink, A.] Erasmus MC, Dept Internal Med, Lab Vasc Med, Rotterdam, Netherlands.
   [Dehairs, J.; Swinnen, J. V.] Univ Leuven, KU Leuven, Lab Lipid Metab & Canc, Leuven, Belgium.
   [Verhaar, M. C.] Univ Med Ctr Utrecht, Dept Nephrol & Hypertens, Utrecht, Netherlands.
   [Zandbergen, L. M.; Merkus, D.] Ludwig Maximilians Univ Munchen, Univ Clin Munich, Walter Brendel Ctr Expt Med WBex, D-81377 Munich, Germany.
   [Merkus, D.] Munich Heart Alliance MHA, Ctr Cardiovasc Res DZHK, Partner Site Munich, D-81377 Munich, Germany.
   [Merkus, D.] Ludwig Maximilians Univ Munchen, Univ Clin Munich, Interfac Ctr Endocrine & Cardiovasc Dis Network Mo, Munich, Germany.
C3 Erasmus University Rotterdam; Erasmus MC; Erasmus University Rotterdam;
   Erasmus MC; KU Leuven; Utrecht University; Utrecht University Medical
   Center; University of Munich; German Centre for Cardiovascular Research;
   University of Munich
RP Merkus, D (corresponding author), Erasmus MC, Dept Cardiol, Div Expt Cardiol, POB 2040, NL-3000 CA Rotterdam, Netherlands.; Merkus, D (corresponding author), Ludwig Maximilians Univ Munchen, Univ Clin Munich, Walter Brendel Ctr Expt Med WBex, D-81377 Munich, Germany.; Merkus, D (corresponding author), Munich Heart Alliance MHA, Ctr Cardiovasc Res DZHK, Partner Site Munich, D-81377 Munich, Germany.; Merkus, D (corresponding author), Ludwig Maximilians Univ Munchen, Univ Clin Munich, Interfac Ctr Endocrine & Cardiovasc Dis Network Mo, Munich, Germany.
EM d.merkus@erasmusmc.nl
RI Mulder, Monique/JDW-8433-2023; Verhaar, Marianne/AAM-6788-2020; Danser,
   Jan/GLR-1479-2022; Swinnen, Johannes/AAA-2214-2022
OI Mulder, Monique/0000-0003-0460-3645; Swinnen,
   Johannes/0000-0002-7720-5077; Verhaar, Marianne/0000-0002-3276-6428
FU Dutch Cardiovascular Alliance
FX The authors thank Annemarie Verzijl, Lau Blonden and Ingrid Garrelds
   (Erasmus MC, Rotterdam, The Netherlands) for their expert technical
   support.
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NR 94
TC 3
Z9 3
U1 0
U2 0
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0300-8428
EI 1435-1803
J9 BASIC RES CARDIOL
JI Basic Res. Cardiol.
PD OCT
PY 2024
VL 119
IS 5
BP 869
EP 887
DI 10.1007/s00395-024-01055-z
EA MAY 2024
PG 19
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA I2H8U
UT WOS:001234040500001
PM 38796544
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Wang, XS
   Yi, XJ
   Tang, DH
AF Wang, Xishuai
   Yi, Xuejie
   Tang, Donghui
TI Aerobic Exercise Improves Pulmonary Fibrosis by Improving Insulin
   Resistance and Inflammation in Obese Mice
SO FRONTIERS IN PHYSIOLOGY
LA English
DT Article
DE obesity; pulmonary fibrosis; inflammation; oxidative stress; insulin
   resistance; exercise
ID VITAMIN-D; METABOLIC SYNDROME; OXIDATIVE STRESS; SIRT1; REGULATOR;
   CAPACITY; PROTEIN; SYSTEM; CELLS
AB BackgroundPrevious studies have demonstrated that obesity is associated with pulmonary fibrosis. We attempted to identify whether regular aerobic exercise (AE) can protect against high-fat diet (HFD)-associated pulmonary fibrosis. MethodsForty-eight C57BL/6 mice were randomly assigned to four groups: chow group (Ch), chow plus exercise group (CE), obesity group (Ob), and obesity plus exercise group (OE). The mice were fed either an HFD or a chow diet for 16 weeks, and low-intensity aerobic exercise (AE) was performed in the last 8 weeks. We measured the degree of pulmonary fibrosis; pulmonary inflammation; oxidative stress parameters; insulin resistance-related indicators; the number of inflammatory cells in bronchoalveolar lavage fluid (BALF); the mRNA expression levels of IL-10, IL-1 beta, TGF-beta, TNF-alpha, CXCL-1, IL-17, MMP-9, MPO, NE, and sirt-1; and the BALF levels of CXCL-1, IL-17, TGF-beta, IL-10, IL-1 beta, and TNF-alpha in lung tissue. ResultsAE in obese mice protected against obesity-associated pulmonary fibrosis, chronic inflammation, pro-oxidative/antioxidative imbalance, and insulin resistance. AE ameliorated the HFD-induced inflammatory response and neutrophil infiltration in the lung. AE downregulated BALF levels of CXCL-1, IL-1 beta, TNF-alpha IL-17, and TGF-beta but upregulated BALF levels of IL-10. AE decreased IL-1 beta, TGF-beta, TNF-alpha, CXCL-1, IL-17, MMP-9, MPO, and NE mRNA expression levels but upregulated IL-10 and sirt-1 mRNA expression levels in the lung. ConclusionsAE protects against HFD-induced pulmonary fibrosis by improving obesity-associated insulin resistance, chronic low-grade inflammation, and pro-oxidative/antioxidative imbalance. AE improved HFD-induced pulmonary fibrosis by suppressing IL-17, TGF-beta, NE, and MMP-9 expression and activating IL-10 and sirt-1 expression.
C1 [Wang, Xishuai; Tang, Donghui] Beijing Normal Univ, Dept Coll PE & Sports, Beijing, Peoples R China.
   [Wang, Xishuai] Chinese Acad Agr Sci, Inst Anim Sci, Dept Anim Genet Resources, Beijing, Peoples R China.
   [Yi, Xuejie] Shenyang Sport Univ, Dept Kinesiol, Shenyang, Peoples R China.
C3 Beijing Normal University; Chinese Academy of Agricultural Sciences;
   Institute of Animal Science, CAAS; Shenyang Sport University
RP Wang, XS; Tang, DH (corresponding author), Beijing Normal Univ, Dept Coll PE & Sports, Beijing, Peoples R China.; Wang, XS (corresponding author), Chinese Acad Agr Sci, Inst Anim Sci, Dept Anim Genet Resources, Beijing, Peoples R China.
EM 630200346@qq.com; 201831070011@mail.bnu.edu.cn
RI , 大道至简 最基本的往往是最重要的/GLU-0441-2022
OI Wang, Xishuai/0000-0001-5972-0676
FU National Natural Science Foundation of China (NSFC) [71874017, 81472992,
   81273096]; BNU Interdisciplinary Research Foundation for the First-Year
   Doctoral Candidates [BNUXKJC1814]; Natural Science Foundation of
   Liaoning Province [2015020704]
FX Funding This study was supported by the National Natural Science
   Foundation of China (NSFC) (Grant Nos. 71874017, 81472992, and
   81273096), the BNU Interdisciplinary Research Foundation for the
   First-Year Doctoral Candidates (Grant No. BNUXKJC1814), and the Natural
   Science Foundation of Liaoning Province (Grant No. 2015020704).
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NR 43
TC 9
Z9 11
U1 0
U2 33
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1664-042X
J9 FRONT PHYSIOL
JI Front. Physiol.
PD JAN 18
PY 2022
VL 12
AR 785117
DI 10.3389/fphys.2021.785117
PG 8
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA YS3ND
UT WOS:000750586100001
PM 35115954
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Miller, DB
   Karoly, ED
   Jones, JC
   Ward, WO
   Vallanat, BD
   Andrews, DL
   Schladweiler, MC
   Snow, SJ
   Bass, VL
   Richards, JE
   Ghio, AJ
   Cascio, WE
   Ledbetter, AD
   Kodavanti, UP
AF Miller, Desinia B.
   Karoly, Edward D.
   Jones, Jan C.
   Ward, William O.
   Vallanat, Beena D.
   Andrews, Debora L.
   Schladweiler, Mette C.
   Snow, Samantha J.
   Bass, Virginia L.
   Richards, Judy E.
   Ghio, Andrew J.
   Cascio, Wayne E.
   Ledbetter, Allen D.
   Kodavanti, Urmila P.
TI Inhaled ozone (O3)-induces changes in serum metabolomic and
   liver transcriptomic profiles in rats
SO TOXICOLOGY AND APPLIED PHARMACOLOGY
LA English
DT Article
DE Air pollution; Ozone; Metabolic syndrome; Serum metabolomic; Stress
   response
ID AUTONOMIC NERVOUS-SYSTEM; PARTICULATE MATTER; AIR-POLLUTION;
   INSULIN-RESISTANCE; FINE PARTICLES; EXPOSURE; INFLAMMATION; STRESS;
   GLUCOSE; EPINEPHRINE
AB Air pollution has been linked to increased incidence of diabetes. Recently, we showed that ozone (O-3) induces glucose intolerance, and increases serum leptin and epinephrine in Brown Norway rats. In this study, we hypothesized that O-3 exposure will cause systemic changes in metabolic homeostasis and that serum metabolomic and liver transcriptomic profiling will provide mechanistic insights. In the first experiment, male Wistar Kyoto (WRY) rats were exposed to filtered air (FA) or O-3 at 0.25, 0.50, or 1.0 ppm, 6 h/day for two days to establish concentration-related effects on glucose tolerance and lung injury. In a second experiment, rats were exposed to FA or 1.0 ppm O-3, 6 h/day for either one or two consecutive days, and systemic metabolic responses were determined immediately after or 18 h post-exposure. O-3 increased serum glucose and leptin on day 1. Glucose intolerance persisted through two days of exposure but reversed 18 h-post second exposure. O-3 increased circulating metabolites of glycolysis, long-chain free fatty acids, branched-chain amino acids and cholesterol, while 1,5-anhydroglucitol, bile acids and metabolites of TCA cycle were decreased, indicating impaired glycemic control, proteolysis and lipolysis. Liver gene expression increased for markers of glycolysis, TCA cycle and gluconeogenesis, and decreased for markers of steroid and fat biosynthesis. Genes involved in apoptosis and mitochondrial function were also impacted by O-3. In conclusion, short-term O-3 exposure induces global metabolic derangement involving glucose, lipid, and amino acid metabolism, typical of a stress-response. It remains to be examined if these alterations contribute to insulin resistance upon chronic exposure. Published by Elsevier Inc.
C1 [Miller, Desinia B.] Univ N Carolina, Curriculum Toxicol, Chapel Hill, NC USA.
   [Karoly, Edward D.; Jones, Jan C.] Metabolon Inc, Durham, NC USA.
   [Ward, William O.; Vallanat, Beena D.; Andrews, Debora L.] US EPA, Res Cores Unit, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA.
   [Schladweiler, Mette C.; Snow, Samantha J.; Richards, Judy E.; Ghio, Andrew J.; Cascio, Wayne E.; Ledbetter, Allen D.; Kodavanti, Urmila P.] US EPA, Environm Publ Hlth Div, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA.
   [Bass, Virginia L.] Univ N Carolina, Dept Environm Sci & Engn, Gillings Sch Global Publ Hlth, Chapel Hill, NC USA.
C3 University of North Carolina; University of North Carolina Chapel Hill;
   Metabolon; United States Environmental Protection Agency; United States
   Environmental Protection Agency; University of North Carolina;
   University of North Carolina Chapel Hill
RP Kodavanti, UP (corresponding author), US EPA, NHEERL, MD B105-02, Res Triangle Pk, NC 27711 USA.
EM kodavanti.urmila@epa.gov
RI Cascio, Wayne/GPG-0840-2022; Snow, Samantha/E-2614-2013
OI Snow, Samantha/0000-0003-1812-8582; Bass, Virginia/0000-0001-6219-2448
FU University of North Carolina-Chapel Hill's Initiative for Maximizing
   Diversity (IMSD) grant [5R25GM055336]; US-EPA-University of North
   Carolina-Co-Operative Trainee Agreement [CR-83515201]; NIEHS Toxicology
   Training Grant [T32 ES007126]
FX We would like to thank Beth Owens, Barbara Buckley and Christopher
   Gordon of the US EPA for their critical review of the manuscript We
   thank Mr. Dock Terrell of the U.S. EPA for conducting O<INF>3</INF>
   exposures. This research was supported by the University of North
   Carolina-Chapel Hill's Initiative for Maximizing Diversity (IMSD) grant
   (5R25GM055336), US-EPA-University of North Carolina-Co-Operative Trainee
   Agreement (#CR-83515201) and NIEHS Toxicology Training Grant (T32
   ES007126). The funders had no role in study design, data collection and
   analysis, decision to publish, or preparation of the manuscript.
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NR 64
TC 114
Z9 121
U1 2
U2 47
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0041-008X
EI 1096-0333
J9 TOXICOL APPL PHARM
JI Toxicol. Appl. Pharmacol.
PD JUL 15
PY 2015
VL 286
IS 2
BP 65
EP 79
DI 10.1016/j.taap.2015.03.025
PG 15
WC Pharmacology & Pharmacy; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Toxicology
GA CK3MG
UT WOS:000356119600001
PM 25838073
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Iwasaki, Y
   Kambayashi, M
   Asai, M
   Yoshida, M
   Nigawara, T
   Hashimoto, K
AF Iwasaki, Yasumasa
   Kambayashi, Machiko
   Asai, Masato
   Yoshida, Masanori
   Nigawara, Takeshi
   Hashimoto, Kozo
TI High glucose alone, as well as in combination with proinflammatory
   cytokines, stimulates nuclear factor kappa-B-mediated transcription in
   hepatocytes in vitro
SO JOURNAL OF DIABETES AND ITS COMPLICATIONS
LA English
DT Article
DE diabetes mellitus; hyperglycemia; nuclear factor-kappa B; oxidative
   stress; cytokine; hypercoagulation
ID CARDIOVASCULAR-DISEASE; SUPEROXIDE-PRODUCTION; ENDOTHELIAL-CELLS;
   ACTIVATION; EXPRESSION; FIBRINOGEN; STRESS; HYPERGLYCEMIA; MECHANISMS;
   TOLERANCE
AB Diabetes mellitus is frequently associated with coagulation disorders such as coronary heart disease and stroke. We aimed to clarify the molecular mechanism whereby hyperglycemia causes the procoagulant state. HuH7 human hepatocyte cells were treated with high glucose alone or in combination with proinflammatory cytokines, and the effects on the activity of the transcription factor nuclear factor kappa-B (NF-kappa B), which mediates the expression of acute-phase and coagulation-related genes, were examined. The results showed that increasing the medium glucose concentration from 3 to 24 mM significantly enhanced NF-kappa B-luciferase activity by 40% in the presence of insulin. The effect was promoter specific and not mimicked by comparable hyperosmolality with L-glucose. Proinflammatory cytokines such as interleukin-1 and tumor necrosis factor-alpha (TNF-alpha) also stimulated NF-kappa B-dependent transcription and showed an additive effect with high glucose. Similar effects were obtained on acute-phase or coagulation/fibrinolysis-related gene promoters such as fibrinogen or plasminogen activator inhibitor-1, all of which are shown to have NF-kappa B-mediated transcription. Finally, pretreatment of the cells with an antioxidant PDTC completely abolished the effect of high glucose and markedly attenuated that of TNF-alpha, suggesting the involvement of reactive oxygen species. These results suggest that (1) high glucose as well as proinflammatory cytokines have positive effects on NF-kappa B-mediated transcription in an additive manner and enhance coagulation-related gene expression and (2) the effects are mediated, at least partly, by the generation of oxidative stress and may be responsible for the high prevalence of thrombotic disorders in the metabolic syndrome with diabetes, hyperinsulinemia, obesity, and/or inflammation. (c) 2007 Elsevier Inc. All rights reserved.
C1 Kochi Univ, Kochi Med Sch, Dept Endocrinol Metab & Nephrol, Nankoku, Kochi 7838505, Japan.
   Nagoya Univ, Grad Sch Med, Dept Med, Nagoya, Aichi 4668550, Japan.
   Nagoya Univ, Grad Sch Med, Dept Clin Pathophysiol, Nagoya, Aichi 4668550, Japan.
C3 Kochi University; Nagoya University; Nagoya University
RP Iwasaki, Y (corresponding author), Kochi Univ, Kochi Med Sch, Dept Endocrinol Metab & Nephrol, Oko Cho, Nankoku, Kochi 7838505, Japan.
EM iwasaki@med.kochi-u.ac.jp
RI asai, masato/I-7294-2014
OI Asai, Masato/0000-0001-6397-373X
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NR 32
TC 52
Z9 64
U1 0
U2 3
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1056-8727
EI 1873-460X
J9 J DIABETES COMPLICAT
JI J. Diabetes Complications
PD JAN-FEB
PY 2007
VL 21
IS 1
BP 56
EP 62
DI 10.1016/j.jdiacomp.2006.02.001
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 125SM
UT WOS:000243462800009
PM 17189875
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Hermsdorff, HHM
   Zulet, MA
   Puchau, B
   Martínez, JA
AF Hermsdorff, Helen Hermana M.
   Angeles Zulet, Maria
   Puchau, Blanca
   Alfredo Martinez, Jose
TI Fruit and vegetable consumption and proinflammatory gene expression from
   peripheral blood mononuclear cells in young adults: a translational
   study
SO NUTRITION & METABOLISM
LA English
DT Article
ID C-REACTIVE PROTEIN; NF-KAPPA-B; ENERGY-RESTRICTED DIETS; LIFE-STYLE
   FACTORS; OXIDATIVE STRESS; SEGUIMIENTO-UNIVERSIDAD; METABOLIC SYNDROME;
   ADIPOSE-TISSUE; FIBER INTAKE; WEIGHT-LOSS
AB Background: Fruits and vegetables are important sources of fiber and nutrients with a recognized antioxidant capacity, which could have beneficial effects on the proinflammatory status as well as some metabolic syndrome and cardiovascular disease features. The current study assessed the potential relationships of fruit and vegetable consumption with the plasma concentrations and mRNA expression values of some proinflammatory markers in young adults.
   Methods: One-hundred and twenty healthy subjects (50 men/70 women; 20.8 +/- 2.6 y; 22.3 +/- 2.8 kg/m(2)) were enrolled. Experimental determinations included anthropometry, blood pressure and lifestyle features as well as blood biochemical and inflammatory measurements. The mRNA was isolated from peripheral blood mononuclear cells (PBMC) and the gene expression concerning selected inflammatory markers was assessed by quantitative real-time PCR. Nutritional intakes were estimated by a validated semi-quantitative food-frequency questionnaire.
   Results: The highest tertile of energy-adjusted fruit and vegetable consumption (> 660 g/d) was associated with lower plasma concentrations of C-reactive protein (CRP) and homocysteine and with lower ICAM1, IL1R1, IL6, TNF alpha and NF kappa B1 gene expression in PBMC (P for trend < 0.05), independently of gender, age, energy intake, physical activity, smoking, body mass index, systolic blood pressure and circulating non-esterified fatty acids. In addition, plasma CRP, homocysteine and TNF alpha concentrations and ICAM1, TNF alpha and NF kappa B1 gene expression in PBMC showed a descending trend as increased fiber intake (> 19.5 g/d) from fruits and vegetables (P for trend < 0.05). Furthermore, the participants within the higher tertile (> 11.8 mmol/d) of dietary total antioxidant capacity showed lower plasma CRP and mRNA values of ICAM1, IL1R1, IL6, TNF alpha and NF kappa B1 genes (P for trend < 0.05). The inverse association between fruit and vegetable consumption and study proinflammatory markers followed the same trend and remained statistically significant, after the inclusion of other foods/nutrients in the linear regression models.
   Conclusion: A higher fruit and vegetable consumption was independently associated not only with reduced CRP and homocysteine concentrations but also with a lower mRNA expression in PBMC of some relevant proinflammatory markers in healthy young adults.
C1 [Hermsdorff, Helen Hermana M.; Angeles Zulet, Maria; Puchau, Blanca; Alfredo Martinez, Jose] Univ Navarra, Dept Nutr Food Sci Physiol & Toxicol, E-31080 Pamplona, Spain.
C3 University of Navarra
RP Martínez, JA (corresponding author), Univ Navarra, Dept Nutr Food Sci Physiol & Toxicol, E-31080 Pamplona, Spain.
EM jalfmtz@unav.es
RI Martinez Hernandez, J Alfredo/K-8709-2014; Zulet, M.
   Angeles/H-1317-2017; Hermsdorff, Helen Hermana Miranda/H-4525-2015
OI Martinez Hernandez, J Alfredo/0000-0001-5218-6941; Zulet, M.
   Angeles/0000-0002-3926-0892; Hermsdorff, Helen Hermana
   Miranda/0000-0002-4441-6572
FU Health Department of the Government of Navarra [22/2007]; Linea Especial
   about Nutrition, Obesity and Health (University of Navarra) [LE/97];
   Capes Foundation; Ministry of Education of Brazil; University of Navarra
   [3756/05-0]
FX We wish to thank our physician Blanca E. Martinez de Morentin, our nurse
   Salome Perez, and our technician Veronica Ciaurriz for excellent
   technical assistance. This work was supported by Health Department of
   the Government of Navarra (22/2007) and by Linea Especial about
   Nutrition, Obesity and Health (University of Navarra LE/97). The Capes
   Foundation, Ministry of Education of Brazil as well as IBERCAJA and ADA
   fellowships scheme of the University of Navarra also provided research
   grants to HHM Hermsdorff (no. 3756/05-0) and B Puchau, respectively.
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NR 57
TC 109
Z9 116
U1 0
U2 6
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1743-7075
J9 NUTR METAB
JI Nutr. Metab.
PD MAY 13
PY 2010
VL 7
AR 42
DI 10.1186/1743-7075-7-42
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 617MM
UT WOS:000279284900001
PM 20465828
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Ma, YL
   Li, ZW
   Wang, Z
   Yang, AJ
AF Ma, Y. L.
   Li, Z. W.
   Wang, Z.
   Yang, A. J.
TI Afamin Ameliorates Testosterone Propionate (TP)-Induced Oxidative Stress
   and Mitochondrial Damage in Human Ovarian Granulosa Tumor Cells (KGN) by
   Upregulating the Expression of SIRT1
SO MOLECULAR BIOLOGY
LA English
DT Article
DE afamin; polycystic ovary syndrome; oxidative stress; mitochondria
   damage; KGN cells; SIRT1
ID VITAMIN-E; REPRODUCTIVE FUNCTION; INSULIN-RESISTANCE; WOMEN; INHIBITION;
   HEALTH; DNA
AB AbstractPolycystic ovary syndrome (PCOS) is a common endocrine disorder affecting women of reproductive age. Considerable research has confirmed that afamin is associated with the prevalence and development of metabolic syndrome. Thus, this study investigated the mechanism of action of afamin in PCOS and its potential therapeutic value. We found that PCOS patients had higher levels of afamin than normal control subjects. Afamin significantly enhanced the overall antioxidant ability and activity of antioxidant enzymes and reduced the levels of 8-hydroxydeoxyguanosine (8-OHdG), malondialdehyde (MDA), reactive oxygen species (ROS) and superoxide anion (\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${\text{O}}_{2}<^>{{\centerdot {\kern 1pt} - }}$$\end{document}) in human ovarian granulosa tumor cells (KGN cells). In addition, afamin was also found to protect KGN cells against testosterone propionate (TP)-induced mitochondrial damage and apoptosis. Additionally, silencing of SIRT1 revealed that SIRT1 protected KGN cells against TP-induced oxidative stress (OS) injury, mitochondrial damage and apoptosis. Furthermore, this study showed that besides restoring the estrous cycle in PCOS mice, afamin might also reduce the increased cycling testosterone (T) and luteinizing hormone (LH) levels and LH/Follicle-stimulating hormone (FSH) ratio, as well as decrease the number of cystic follicles, indicating the significance of afamin in the treatment of PCOS. Moreover, afamin reduced oxidative damage in PCOS mice by enhancing their antioxidant capacity. Also, afamin may protect KGN cells against TP-induced OS by enhancing their antioxidant ability, restoring mitochondrial function, and inhibiting cell apoptosis by upregulating the expression of SIRT1. Thus, afamin may play a protective role in PCOS mice.
C1 [Ma, Y. L.; Wang, Z.] Qingdao Univ, Sch Basic Med, Dept Genet & Cell Biol, Qingdao 266071, Shandong, Peoples R China.
   [Ma, Y. L.; Li, Z. W.; Yang, A. J.] Jining Med Univ, Dept Reprod Med, Affiliated Hosp, Jining 272029, Shandong, Peoples R China.
   [Wang, Z.] Qingdao Univ, Dept Reprod Med, Affiliated Hosp, Qingdao 266000, Shandong, Peoples R China.
C3 Qingdao University; Jining Medical University; Qingdao University
RP Wang, Z (corresponding author), Qingdao Univ, Sch Basic Med, Dept Genet & Cell Biol, Qingdao 266071, Shandong, Peoples R China.; Wang, Z (corresponding author), Qingdao Univ, Dept Reprod Med, Affiliated Hosp, Qingdao 266000, Shandong, Peoples R China.
EM zheng.wang@qdu.edu.cn; yajlws@126.com
RI wang, zheng/H-6328-2013; Yang, Aijun/H-9171-2017
OI Wang, Zheng/0000-0003-4471-5983
FU Postdoctoral program of Affiliated Hospital of Jining Medical University
   [JYFY322156]; Research Fund for the Natural Science Foundation of
   Shandong Province [ZR2023QH478]; Jining Key RD Plan [2023YXNS163];
   Taishan Scholars Program of Shandong Province [TS20190931]; National
   Natural Science Foundation of China [ZR2020MC083]; Shandong Natural
   Science Foundation [ZR2022MH094]; Jining Key RD Plan [2022YXNS027]
FX This work was supported by Postdoctoral program of Affiliated Hospital
   of Jining Medical University (Grant no. JYFY322156). Research Fund for
   the Natural Science Foundation of Shandong Province (Grant no.
   ZR2023QH478) and Jining Key R&D Plan (Grant no. 2023YXNS163). This work
   grants from Taishan Scholars Program of Shandong Province (Grant no.
   TS20190931), the National Natural Science Foundation of China (Grant no.
   32070859) and the Shandong Provincial Natural Science Foundation, China
   (Grant no. ZR2020MC083). This work was supported by Shandong Natural
   Science Foundation (Grant no. ZR2022MH094), Jining Key R&D Plan (Grant
   no. 2022YXNS027).
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NR 58
TC 0
Z9 0
U1 5
U2 5
PU PLEIADES PUBLISHING INC
PI NEW YORK
PA PLEIADES HOUSE, 7 W 54 ST, NEW YORK,  NY, UNITED STATES
SN 0026-8933
EI 1608-3245
J9 MOL BIOL+
JI Mol. Biol.
PD DEC
PY 2024
VL 58
IS 6
BP 1250
EP 1267
DI 10.1134/S0026893324060074
PG 18
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA P9K4N
UT WOS:001381004700002
OA hybrid
DA 2025-06-11
ER

PT J
AU Coehoorn, CJ
   Martin, PS
   Teran, J
   Cowart, H
   Waite, L
   Newman, S
AF Coehoorn, Cory J.
   Martin, Patrick St.
   Teran, Jonathan
   Cowart, Hannah
   Waite, Landon
   Newman, Shelby
TI Firefighter uncompensable heat stress results in excessive upper body
   temperatures measured by infrared thermography: Implications for cooling
   strategies
SO APPLIED ERGONOMICS
LA English
DT Article
DE Heat stress; Firefighting; Thermal mapping; Hyperthermia; Personal
   protective equipment
ID PROLONGED EXERCISE; METABOLIC SYNDROME; THERMAL COMFORT; STROKE VOLUME;
   BLOOD; HYPERTHERMIA; PERFORMANCE; RESPONSES; VELOCITY; RECOVERY
AB This research sought to evaluate the thermal zones of the upper body and firefighter personal protective equipment (PPE) immediately following uncompensable heat stress (0.03 degrees C increase/min). We hypothesized that the frontal portion of the head and the inside of the firefighter helmet would be the hottest as measured by infrared thermography. This hypothesis was due to previous research demonstrating that the head accounts for similar to 8-10% of the body surface area, but it accounts for similar to 20% of the overall body heat dissipation during moderate exercise. Twenty participants performed a 21-min graded treadmill exercise protocol (Altered Modified Naughton) in an environmental chamber (35 degrees C, 50 % humidity) in firefighter PPE. The body areas analyzed were the frontal area of the head, chest, abdomen, arm, neck, upper back, and lower back. The areas of the PPE that were analyzed were the inside of the helmet and the jacket. The hottest areas of the body post-exercise were the frontal area of the head (mean: 37.3 +/- 0.4 degrees C), chest (mean: 37.5 +/- 0.3 degrees C), and upper back (mean: 37.3 +/- 0.4 degrees C). The coldest area of the upper body was the abdomen (mean: 36.1 +/- 0.4 degrees C). The peak temperature of the inside of the helmet increased (p < 0.001) by 9.8 degrees C from 27.7 +/- 1.6 degrees C to 37.4 +/- 0.7 degrees C, and the inside of the jacket increased (p < 0.001) by 7.3 degrees C from 29.2 +/- 1.7 degrees C to 36.5 +/- 0.4 degrees C. The results of this study are relevant for cooling strategies for firefighters.
C1 [Coehoorn, Cory J.; Martin, Patrick St.; Teran, Jonathan; Cowart, Hannah; Waite, Landon; Newman, Shelby] Louisiana State Univ Hlth Shreveport, Shreveport, LA USA.
C3 Louisiana State University System; Louisiana State University Health
   Sciences Center at Shreveport
RP Coehoorn, CJ (corresponding author), 1501 Kings Highway, Shreveport, LA 71103 USA.
EM cory.coehoorn@lsuhs.edu
RI Coehoorn, Cory/ABA-3497-2021
OI Coehoorn, Cory/0000-0002-5026-9548; Newman, Shelby/0009-0004-4212-2521;
   , Hannah Cowart/0009-0009-0506-7814
FX We would also like to thank all participants for volunteering for this
   research.
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NR 48
TC 2
Z9 2
U1 1
U2 6
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 0003-6870
EI 1872-9126
J9 APPL ERGON
JI Appl. Ergon.
PD OCT
PY 2024
VL 120
AR 104342
DI 10.1016/j.apergo.2024.104342
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PG 7
WC Engineering, Industrial; Ergonomics; Psychology, Applied
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Engineering; Psychology
GA XY8Z4
UT WOS:001265345300001
PM 38959633
DA 2025-06-11
ER

PT J
AU Silva, MPDF
   Ferreira, MJ
   Shecaira, TP
   Dias, DD
   Kimura, DC
   Irigoyen, MC
   Gomes, GN
   De Angelis, K
AF Silva, Michel Pablo dos Santos Ferreira
   Ferreira, Maycon Junior
   Shecaira, Tania Plens
   Dias, Danielle da Silva
   Kimura, Debora Conte
   Irigoyen, Maria Claudia
   Gomes, Guiomar Nascimento
   De Angelis, Katia
TI Impact of exercise training associated with enalapril treatment on blood
   pressure variability and renal dysfunctions in an experimental model of
   arterial hypertension and postmenopause
SO PLOS ONE
LA English
DT Article
ID CARDIOVASCULAR AUTONOMIC CONTROL; OXIDATIVE STRESS; BAROREFLEX
   SENSITIVITY; METABOLIC SYNDROME; HYDROGEN-PEROXIDE; DISEASE; DAMAGE;
   RESISTANCE; HEART; RATS
AB Objective In this study, we aimed to investigate the effects of the concurrent exercise training (CET) associated with the enalapril maleate on blood pressure variability (BPV) and renal profile in an experimental model of arterial hypertension (AH) and postmenopause.Methods Female ovariectomized spontaneously hypertensive rats (SHR) were distributed into 4 groups (n = 8/group): sedentary (SO), sedentary + enalapril (SOE), trained (TO) and trained + enalapril (TOE). Both enalapril (3mg/kg) and CET (3 days/week) were conducted during 8 weeks. Blood pressure (BP) was directly recorded for BPV analyses. Renal function, morphology, inflammation and oxidative stress were assessed.Results The SOE, TO e TOE groups presented decreased systolic BP compared with SO. Both trained groups (TO and TOE) presented lower BPV and increased baroreflex sensitivity (TO: 0.76 +/- 0.20 and TOE: 1.02 +/- 0.40 vs. SO: 0.40 +/- 0.07 ms/mmHg) compared with SO group, with additional improvements in TOE group. Creatinine and IL-6 levels were reduced in SOE, TO and TOE compared with SO group, while IL-10 was increased only in TOE group (vs. SO). Enalapril combined with CET promote reduction in lipoperoxidation (TOE: 1.37 +/- 0.26 vs. SO: 2.08 +/- 0.48 and SOE: 1.84 +/- 0.35 mu mol/mg protein) and hydrogen peroxide (TOE: 1.89 +/- 0.40 vs. SO: 3.70 +/- 0.19 and SOE: 2.73 +/- 0.70 mu M), as well as increase in catalase activity (vs. sedentary groups). The tubulointerstitial injury was lower in interventions groups (SOE, TO and TOE vs. SO), with potentialized benefits in the trained groups.Conclusions Enalapril combined with CET attenuated BPV and baroreflex dysfunctions, probably impacting on end-organ damage, as demonstrated by attenuation in the AH-induced renal inflammations, oxidative stress and morphofunctional impairments in postmenopausal rats.
C1 [Silva, Michel Pablo dos Santos Ferreira; Shecaira, Tania Plens; De Angelis, Katia] Univ Nove Julho UNINOVE, Translat Physiol Lab, Sao Paulo, SP, Brazil.
   [Ferreira, Maycon Junior; Shecaira, Tania Plens; Dias, Danielle da Silva; De Angelis, Katia] Univ Fed Sao Paulo UNIFESP, Exercise Physiol Lab, Sao Paulo, SP, Brazil.
   [Dias, Danielle da Silva] Univ Sao Paulo, Heart Inst InCor, Sch Med, Hypertens Unit, Sao Paulo, SP, Brazil.
   [Dias, Danielle da Silva; Irigoyen, Maria Claudia] Univ Fed Maranhao, Postgrad Program Phys Educ, Sao Luis, MA, Brazil.
   [Kimura, Debora Conte; Gomes, Guiomar Nascimento] Univ Fed Sao Paulo UNIFESP, Dept Physiol, Sao Paulo, SP, Brazil.
C3 Universidade Nove de Julho; Universidade Federal de Sao Paulo (UNIFESP);
   Universidade de Sao Paulo; Universidade Federal do Maranhao;
   Universidade Federal de Sao Paulo (UNIFESP)
RP De Angelis, K (corresponding author), Univ Nove Julho UNINOVE, Translat Physiol Lab, Sao Paulo, SP, Brazil.; De Angelis, K (corresponding author), Univ Fed Sao Paulo UNIFESP, Exercise Physiol Lab, Sao Paulo, SP, Brazil.
EM prof.kangelis@yahoo.com.br
RI Gomes, Guiomar/E-6345-2013; Ferreira, Maycon/AET-1400-2022; DE ANGELIS,
   KATIA/I-6098-2016; IRIGOYEN, MARIA/N-6880-2014; da Silva Dias,
   Danielle/AAN-7618-2020
OI Junior Ferreira, Maycon/0000-0001-7198-1908; Gomes,
   Guiomar/0000-0002-6687-9885; Conte Kimura Lichtenecker,
   Debora/0000-0003-0456-4949
FU FAPESP [2019/06277-0]; Sao Paulo Research Foundation; National Council
   for Scientific and Technological Development (CNPq) [406792/2022-4];
   FAPESP Scholarship; CNPq Fellowship (CNPq-BPQ)
FX FAPESP (2019/06277-0), Sao Paulo Research Foundation
   (https://fapesp.br/). National Council for Scientific and Technological
   Development (CNPq) (406792/2022-4) (https://www.gov.br/cnpq/pt-br).
   Maycon Junior Ferreira is a beneficiary of the FAPESP Scholarship, while
   Katia De Angelis and Maria Claudia Irigoyen are recipients of the CNPq
   Fellowship (CNPq-BPQ). Please note that the funders played no role in
   the study's design, data collection and analysis, decision to publish,
   or manuscript preparation.
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NR 55
TC 3
Z9 3
U1 0
U2 5
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JAN 10
PY 2024
VL 19
IS 1
AR e0296687
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PG 16
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA GO6A5
UT WOS:001153638300026
PM 38198460
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Frias-toral, E
   Garcia-velasquez, E
   Carignano, MD
   Rodriguez-veintimilla, D
   Alvarado-aguilera, I
   Bautista-litardo, N
AF Frias-toral, Evelyn
   Garcia-velasquez, Eloisa
   Carignano, Maria de los A. N. G. E. L. E. S.
   Rodriguez-veintimilla, Dolores
   Alvarado-aguilera, Irene
   Bautista-litardo, Noemi
TI Polycystic ovary syndrome and obesity: clinical aspects and nutritional
   management
SO MINERVA ENDOCRINOLOGY
LA English
DT Review
DE Polycystic ovary syndrome; Oxidative stress; Obesity; Hyperandrogenism;
   Insulin resistance; Life style
ID VITAMIN-D LEVELS; GLYCATION END-PRODUCTS; C-REACTIVE PROTEIN; N-3
   FATTY-ACIDS; OXIDATIVE STRESS; CARDIOVASCULAR-DISEASE;
   INSULIN-RESISTANCE; CHROMIUM SUPPLEMENTATION; METABOLIC SYNDROME; LIPID
   PROFILES
AB Polycystic ovary syndrome (PCOS) is a multifactorial endocrine and metabolic disorder characterized by androgen ex-cess, oligo-anovulatory infertility, polycystic ovaries in ultrasound examination, insulin resistance, and cardiometabolic disorders, with overweight/obesity and visceral adiposity. This review aims to provide an overview of the clinical charac-teristics and nutritional therapy of PCOS and obesity. The authors analyzed the updated and relevant publications found on PubMed about clinical aspects and nutritional management of PCOS and obesity in studies done in animal and human models. It is crucial an early detection and intervention in PCOS patients to avoid the more challenging control of the onset of more impaired-health conditions that this pathology causes. It is presented evidence that clearly shows the close interaction among oxidative stress, low-grade inflammation, and PCOS. It is also analyzed the relevance of treating meta-bolic and nutritional correlations of PCOS with a complete therapeutic strategy that includes individualized medication, diet, and healthy habits. By an integral approach and treatment that includes not only medications for PCOS symptoms, supplementation of minerals and vitamins to control PCOS complications but an anti-inflammatory diet, nutritional edu-cation, exercise individualized program, lifestyle changes, it is possible to improve insulin resistance, sustained weight loss, ovulation rates, among other goals for the management of this disease. Further studies are needed to clarify mecha-nisms, beneficial effects, and doses of supplements and precise medication to determine the best combination of diets and exercise programs according to these patients' specific requirements. (Cite this article as: Frias-Toral E, Garcia-Velasquez E, De los Angeles Carignano M, Rodriguez-Veintimilla D, Alvarado-Aguilera I, Bautista-Litardo N. Polycystic ovary syndrome and obesity: clinical aspects and nutritional management. Minerva Endocrinol 2022;47:215-41. DOI: 10.23736/S2724-6507.21.03349-6)
C1 [Frias-toral, Evelyn] SOLCA, Res Comm, Guayaquil, Ecuador.
   [Frias-toral, Evelyn] Catholic Univ Santiago Guayaquil, Guayaquil, Ecuador.
   [Garcia-velasquez, Eloisa] San Francisco Clin Hosp, Clin Nutr Serv, Guayaquil, Ecuador.
   [Carignano, Maria de los A. N. G. E. L. E. S.] Hosp Italiano Buenos Aires, Nutr Support Serv, Buenos Aires, Argentina.
   [Rodriguez-veintimilla, Dolores] Clin Nutr & Dietet Serv, SOLCA, Guayaquil, Ecuador.
   [Alvarado-aguilera, Irene] Espiritu Santo Univ, Guayaquil, Ecuador.
   [Frias-toral, Evelyn] SOLCA, Res Comm, Ave Pedro Menendez gilbert, Guayaquil 090505, Ecuador.
C3 University of Buenos Aires; University of Buenos Aires Hospital;
   Hospital Italiano de Buenos Aires; Universidad de Especialidades
   Espiritu Santo
RP Frias-toral, E (corresponding author), SOLCA, Res Comm, Guayaquil, Ecuador.; Frias-toral, E (corresponding author), Catholic Univ Santiago Guayaquil, Guayaquil, Ecuador.; Frias-toral, E (corresponding author), SOLCA, Res Comm, Ave Pedro Menendez gilbert, Guayaquil 090505, Ecuador.
EM evelyn.frias@cu.ucsg.edu.ec
RI Frias-Toral, Evelyn/AAZ-7346-2020
OI Frias-Toral, Evelyn/0000-0002-2228-0141; Garcia - Velasquez,
   Eloisa/0000-0002-0210-9726; BAUTISTA, NOEMI/0000-0002-6321-970X
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NR 158
TC 23
Z9 23
U1 0
U2 15
PU EDIZIONI MINERVA MEDICA
PI TURIN
PA CORSO BRAMANTE 83-85 INT JOURNALS DEPT., 10126 TURIN, ITALY
SN 2724-6507
EI 2724-6116
J9 MINERVA ENDOCRINOL
JI Minerva Endocrinol.
PD JUN
PY 2022
VL 47
IS 2
BP 215
EP 241
DI 10.23736/S2724-6507.21.03349-6
PG 27
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 3D8JN
UT WOS:000829542500006
PM 33792235
DA 2025-06-11
ER

PT J
AU N'guessan, BB
   Twumasi-Ankrah, JS
   Amponsah, SK
   Adams, I
   Poakwah, AKK
   Brown, C
   Adinortey, MB
   Sarkodie, JA
   Adi-Dako, O
   Asiedu-Gyekye, IJ
   Appiah-Opong, R
AF N'guessan, Benoit Banga
   Twumasi-Ankrah, Jessica Sarpongmaa
   Amponsah, Seth Kwabena
   Adams, Ismaila
   Poakwah, Albert Kyei-Kankam
   Brown, Charles
   Adinortey, Michael Buenor
   Sarkodie, Joseph Adusei
   Adi-Dako, Ofosua
   Asiedu-Gyekye, Isaac Julius
   Appiah-Opong, Regina
TI Effect of Metaswitch® dietary supplement on anthropometric parameters,
   serum lipids, glucose level, oxidative stress and in vivo antioxidant
   properties in high fat diet-induced overweight Sprague Dawley rats
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Article
DE Overweight; Metaswitch (R); Weight-loss; Serum lipids; Oxidative stress;
   Dietary supplement; Antioxidant systems; Sprague Dawley
ID LIPOPROTEIN-CHOLESTEROL RATIO; INDUCED OBESITY; LIPOIC ACID;
   WEIGHT-LOSS; FOOD-INTAKE; CARDIOVASCULAR RISK; METABOLIC SYNDROME;
   ADIPOSE-TISSUE; NUTRITION TRANSITION; INSULIN-RESISTANCE
AB Purpose: Obesity and overweight are metabolic disorders associated with oxidative stress, and risk factors for many chronic diseases. We sought to investigate the effects of Metaswitch dietary supplement on weight gain and associated acute metabolic alterations in a high-fat diet-induced overweight rat model.
   Methods: Female Sprague Dawley (SD) rats were put into 6 groups. Control groups were fed normal (NCD) or high-fat diet (HFD). Treatment groups on HFD receieved 3 different daily doses of Metaswitch for 3 weeks. Another group on HFD received Slimrite (R) (phenylpropanolamine), a standard drug. Rats on HFD also received cyproheptadine to stimulate appetite. Food consumption and anthropometric parameters were determined weekly. Serum lipids, glucose level, hepatic lipid peroxidation, and antioxidant activity were used to assess overweight in rats.
   Results: Food intake remained relatively constant among groups. Rats on HFD had significantly increased body weight compared to rats fed NCD. Metaswitch significantly prevented weight gain; this effect was greater or similar to rats administered Slimrite, but was not dose-dependant. No significant changes occurred in the levels of serum lipids and glucose among the groups. However, serum triglyceride (TG) was significantly increased. The TG/HDL-C ratio revealed significant metabolic alterations which was prevented by Metaswitch. Catalase activity was significantly decreased in the HFD untreated group but was restored in Metaswitch-treated groups.
   Conclusions: A 3-week HFD regimen with cyproheptadine supplementation in female SD rats resulted in a sig-nificant increase in body weight and acute metabolic alterations. The aforementioned changes were found to have been prevented with the administration of Metaswitch.
C1 [N'guessan, Benoit Banga; Twumasi-Ankrah, Jessica Sarpongmaa; Adams, Ismaila; Poakwah, Albert Kyei-Kankam; Asiedu-Gyekye, Isaac Julius] Univ Ghana, Coll Hlth Sci, Sch Pharm, Dept Pharmacol & Toxicol, POB LG 43 Legon, Accra, Ghana.
   [Amponsah, Seth Kwabena] Univ Ghana, Coll Hlth Sci, Med Sch, Dept Med Pharmacol, Accra, Ghana.
   [Poakwah, Albert Kyei-Kankam] Univ Ghana, Coll Hlth Sci, Sch Biomed & Allied Hlth Sci, Dept Nutr & Dietet, Accra, Ghana.
   [Brown, Charles] Univ Ghana, Coll Hlth Sci, Sch Biomed & Allied Hlth Sci, Dept Med Lab Sci, Accra, Ghana.
   [Adinortey, Michael Buenor] Univ Cape Coast, Sch Biol Sci, Dept Biochem, Cape Coast, Ghana.
   [Sarkodie, Joseph Adusei] Univ Ghana, Coll Hlth Sci, Sch Pharm, Dept Pharmacognosy & Herbal Med, POB LG 43 Legon, Accra, Ghana.
   [Adi-Dako, Ofosua] Univ Ghana, Coll Hlth Sci, Sch Pharm, Dept Pharmaceut & Microbiol, Accra, Ghana.
   [Appiah-Opong, Regina] Univ Ghana, Noguchi Mem Inst Med Res, Coll Hlth Sci, Dept Clin Pathol, Accra, Ghana.
C3 University of Ghana; University of Ghana; University of Ghana;
   University of Ghana; University of Cape Coast; University of Ghana;
   University of Ghana; University of Ghana
RP N'guessan, BB (corresponding author), Univ Ghana, Coll Hlth Sci, Sch Pharm, Dept Pharmacol & Toxicol, POB LG 43 Legon, Accra, Ghana.
EM bbnguessan@ug.edu.gh
RI Adinortey, michael/K-3935-2019; N'guessan, Benoit/AAH-6421-2020;
   Asiedu-Gyekye, Isaac/AHC-4397-2022; Brown, Charles/J-3366-2014;
   Adi-Dako, Ofosua/AES-0121-2022; Sarkodie, Joseph Adusei/HNB-4654-2023; ,
   Charles/JGL-6343-2023
OI Adams, Ismaila/0000-0001-7113-3888; , Charles/0000-0002-7050-2634;
   Asiedu-Gyekye, Isaac/0000-0003-3902-5689; Sarkodie, Joseph
   Adusei/0000-0002-7306-3964; Adinortey, michael
   Buenor/0000-0001-8287-7460
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NR 76
TC 8
Z9 8
U1 0
U2 5
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD MAY
PY 2022
VL 149
AR 112892
DI 10.1016/j.biopha.2022.112892
EA MAR 2022
PG 11
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA 0Z7LT
UT WOS:000791256000007
PM 35358796
OA gold
DA 2025-06-11
ER

PT J
AU Schönfeld, P
   Reiser, G
AF Schoenfeld, Peter
   Reiser, Georg
TI How the brain fights fatty acids' toxicity
SO NEUROCHEMISTRY INTERNATIONAL
LA English
DT Review
DE Astrocytes; Autophagy; Lipotoxicity; Metabolic trafficking;
   Mitochondria; Oxidative stress
ID ADENINE-NUCLEOTIDE TRANSLOCASE; SUPPLIES DOCOSAHEXAENOIC ACID;
   HYDROGEN-PEROXIDE PRODUCTION; IN-VIVO INCORPORATION; CYTOCHROME-C
   RELEASE; INDUCED ER STRESS; ENERGY-METABOLISM; LIPID DROPLETS; AXONAL
   DEGENERATION; OXIDATIVE STRESS
AB Neurons spurn hydrogen-rich fatty acids for energizing oxidative ATP synthesis, contrary to other cells. This feature has been mainly attributed to a lower yield of ATP per reduced oxygen, as compared to glucose. Moreover, the use of fatty acids as hydrogen donor is accompanied by severe beta-oxidation-associated ROS generation. Neurons are especially susceptible to detrimental activities of ROS due to their poor antioxidative equipment. It is also important to note that free fatty acids (FFA) initiate multiple harmful activities inside the cells, particularly on phosphorylating mitochondria. Several processes enhance FFA-linked lipotoxicity in the cerebral tissue. Thus, an uptake of FFA from the circulation into the brain tissue takes place during an imbalance between energy intake and energy expenditure in the body, a situation similar to that during metabolic syndrome and fat-rich diet. Traumatic or hypoxic brain injuries increase hydrolytic degradation of membrane phospholipids and, thereby elevate the level of FFA in neural cells. Accumulation of FFA in brain tissue is markedly associated with some inherited neurological disorders, such as Refsum disease or X-linked adrenoleukodystrophy (X-ALD). What are strategies protecting neurons against FFA-linked lipotoxicity? Firstly, spurning the beta-oxidation pathway in mitochondria of neurons. Secondly, based on a tight metabolic communication between neurons and astrocytes, astrocytes donate metabolites to neurons for synthesis of antioxidants. Further, neuronal autophagy of ROS-emitting mitochondria combined with the transfer of degradation-committed FFA for their disposal in astrocytes, is a potent protective strategy against ROS and harmful activities of FFA. Finally, estrogens and neurosteroids are protective as triggers of ERK and PKB signaling pathways, consequently initiating the expression of various neuronal survival genes via the formation of cAMP response element-binding protein (CREB).
C1 [Schoenfeld, Peter] Otto von Guericke Univ, Inst Biochem & Zellbiol, Med Fak, Leipziger Str 44, D-39120 Magdeburg, Germany.
   [Reiser, Georg] Otto von Guericke Univ, Inst Inflammat & Neurodegenerat Neurobiochem, Med Fak, Leipziger Str 44, D-39120 Magdeburg, Germany.
C3 Otto von Guericke University; Otto von Guericke University
RP Reiser, G (corresponding author), Otto von Guericke Univ, Inst Inflammat & Neurodegenerat Neurobiochem, Med Fak, Leipziger Str 44, D-39120 Magdeburg, Germany.
EM georg.reiser@med.ovgu.de
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NR 196
TC 37
Z9 38
U1 1
U2 22
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0197-0186
EI 1872-9754
J9 NEUROCHEM INT
JI Neurochem. Int.
PD SEP
PY 2021
VL 148
AR 105050
DI 10.1016/j.neuint.2021.105050
EA MAY 2021
PG 12
WC Biochemistry & Molecular Biology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Neurosciences & Neurology
GA TM9KI
UT WOS:000675865200001
PM 33945834
DA 2025-06-11
ER

PT J
AU Mehanna, ET
   El-Sayed, NM
   Ibrahim, AK
   Ahmed, SA
   Abo-Elmatty, DM
AF Mehanna, Eman T.
   El-sayed, Norhan M.
   Ibrahim, Amany K.
   Ahmed, Safwat A.
   Abo-Elmatty, Dina M.
TI Isolated compounds from Cuscuta pedicellata ameliorate oxidative
   stress and upregulate expression of some energy regulatory genes in high
   fat diet induced obesity in rats
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Article
DE Cuscuta pedicellata; Insulin resistance; Antioxidant enzymes; Uncoupling
   protein-1; Carnitine palmitoyltransferase-1
ID BROWN ADIPOSE-TISSUE; INSULIN-RESISTANCE; METABOLIC SYNDROME; MICE;
   MITOCHONDRIA; INFLAMMATION; QUERCETIN
AB Background: Cuscuta pedicellata and some of its isolated compounds were suggested previously to have an antiobesity effect in rats. This study aimed to investigate the effect of ten isolated compounds from C. pedicellata on insulin resistance, some oxidative stress markers and expression of the mitochondrial uncoupling protein-1 (UCP-1) and Carnitine palmitoyltransferase-I (CPT-1) genes in brown adipose tissue of high fat diet (HFD) rats.
   Methods: One hundred and four male albino rats were divided into 13 groups. Group (1) was considered as normal untreated rats. Obesity was induced in all other groups by HFD. Group (2) served as obese control group and groups (3-11) were treated for four weeks with C. pedicellata extract or one of its isolated compounds (naringenin, kaempferol, aromadenderin, quercetin, 3,5,7,30,50-pentahydroxy flavanone, naringenin-7-O-b-D-glucoside, aromadenderin-7-O-b-D-glucoside, taxifolin 7-O-b-D-glucoside, kaempferol-3-O-b-D-glucoside [astragalin], and quercitin-3-O-b-D-glucoside [isoquercitrin]). At the end of the experiment, rats were then sacrificed under anesthesia and their brown adipose tissues were dissected out for determination of UCP-1 and CPT-1 genes using quantitative PCR. Blood samples were collected for determination of blood glucose, insulin, thiobarbituric acid reactive substances (TBARS), superoxide dismutase (SOD) and catalase.
   Results: A significant reduction in homeostasis model assessment-insulin resistance (HOMA-IR) and TBARS levels was observed in rats treated with C. pedicellata crude extract and some of its isolated compounds, with a significant increase in SOD and catalase levels and upregulation of UCP-1 and CPT-1 genes expression compared to the obese control group.
   Conclusions: This study suggests a beneficiary role of C. pedicellata in reducing insulin resistance, oxidative stress and enhancing energy expenditure.
C1 [Mehanna, Eman T.; Abo-Elmatty, Dina M.] Suez Canal Univ, Dept Biochem, Fac Pharm, Ismailia 41522, Egypt.
   [El-sayed, Norhan M.] Suez Canal Univ, Dept Pharmacol & Toxicol, Fac Pharm, Ismailia, Egypt.
   [Ibrahim, Amany K.; Ahmed, Safwat A.] Suez Canal Univ, Dept Pharmacognosy, Fac Pharm, Ismailia, Egypt.
C3 Egyptian Knowledge Bank (EKB); Suez Canal University; Egyptian Knowledge
   Bank (EKB); Suez Canal University; Egyptian Knowledge Bank (EKB); Suez
   Canal University
RP Mehanna, ET (corresponding author), Suez Canal Univ, Dept Biochem, Fac Pharm, Ismailia 41522, Egypt.
EM eman.taha@pharm.suez.edu.eg
RI Naguib, Ibrahim/ABM-0813-2022; ahmed, ahmed/JZD-7597-2024; M. El-Sayed,
   Norhan/GLT-2251-2022; Mehanna, Eman/GPX-1983-2022
OI Ahmed, Safwat/0000-0002-8753-6400; Ibrahim, Amany/0000-0002-1506-0044;
   M. El-Sayed, Norhan/0000-0002-0432-3152; abo-elmatty,
   dina/0000-0002-6074-2714; Mehanna, Eman/0000-0003-2759-2889
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NR 30
TC 21
Z9 23
U1 1
U2 18
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD DEC
PY 2018
VL 108
BP 1253
EP 1258
DI 10.1016/j.biopha.2018.09.126
PG 6
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA HA2UZ
UT WOS:000450101800140
PM 30372826
OA hybrid
DA 2025-06-11
ER

PT J
AU Short, JD
   Tavakoli, S
   Nguyen, HN
   Carrera, A
   Farnen, C
   Cox, LA
   Asmis, R
AF Short, John D.
   Tavakoli, Sina
   Huynh Nga Nguyen
   Carrera, Ana
   Farnen, Chelbee
   Cox, Laura A.
   Asmis, Reto
TI Dyslipidemic Diet-induced Monocyte "Priming" and Dysfunction in
   non-human Primates is Triggered by elevated Plasma cholesterol and
   accompanied by altered histone acetylation
SO FRONTIERS IN IMMUNOLOGY
LA English
DT Article
DE diabetes; monocytes; mitogen-activated protein kinase phosphatase 1;
   histone; epigenetics
ID RECEPTOR-DEFICIENT MICE; METABOLIC SYNDROME; EXPERIMENTAL
   ATHEROSCLEROSIS; MACROPHAGE DIFFERENTIATION; REDOX REGULATION;
   ADIPOSE-TISSUE; LDL RECEPTOR; OBESITY; BABOONS; HYPERCHOLESTEROLEMIA
AB Monocytes and the recruitment of monocyte-derived macrophages into sites of inflammation play a key role in atherogenesis and other chronic inflammatory diseases linked to cardiometabolic syndrome and obesity. Previous studies from our group have shown that metabolic stress promotes monocyte priming, i.e., enhanced adhesion and accelerated chemotaxis of monocytes in response to chemokines, both in vitro and in dyslipidemic LDLR-/- mice. We also showed that metabolic stress-induced monocyte dysfunction is, at least to a large extent caused by the S-glutathionylation, inactivation, and subsequent degradation of mitogen-activated protein kinase phosphatase 1. Here, we analyzed the effects of a Western-style, dyslipidemic diet (DD), which was composed of high levels of saturated fat, cholesterol, and simple sugars, on monocyte (dys) function in non-human primates (NHPs). We found that similar to mice, a DD enhances monocyte chemotaxis in NHP within 4 weeks, occurring concordantly with the onset of hypercholesterolemia but prior to changes in triglycerides, blood glucose, monocytosis, or changes in monocyte subset composition. In addition, we identified transitory decreases in the acetylation of histone H3 at the lysine residues 18 and 23 in metabolically primed monocytes, and we found that monocyte priming was correlated with the acetylation of histone H3 at lysine 27 after an 8-week DD regimen. Our data show that metabolic stress promotes monocyte priming and hyper-chemotactic responses in NHP. The histone modifications accompanying monocyte priming in primates suggest a reprogramming of the epigenetic landscape, which may lead to dysregulated responses and functionalities in macrophages derived from primed monocytes that are recruited to sites of inflammation.
C1 [Short, John D.; Carrera, Ana] Univ Texas Hlth Sci Ctr San Antonio, Dept Pharmacol, San Antonio, TX 78229 USA.
   [Tavakoli, Sina; Asmis, Reto] Univ Texas Hlth Sci Ctr San Antonio, Dept Radiol, San Antonio, TX 78229 USA.
   [Huynh Nga Nguyen; Asmis, Reto] Univ Texas Hlth Sci Ctr San Antonio, Dept Biochem & Struct Biol, San Antonio, TX 78229 USA.
   [Farnen, Chelbee] Univ Texas Hlth Sci Ctr San Antonio, Dept Mol Med, San Antonio, TX 78229 USA.
   [Cox, Laura A.] Texas Biomed Res Inst, Dept Genet, San Antonio, TX USA.
   [Cox, Laura A.] Southwest Natl Primate Res Ctr, San Antonio, TX USA.
   [Asmis, Reto] Univ Texas Hlth Sci Ctr San Antonio, Dept Clin Lab Sci, San Antonio, TX 78229 USA.
C3 University of Texas System; University of Texas Health Science Center at
   San Antonio; University of Texas System; University of Texas Health
   Science Center at San Antonio; University of Texas System; University of
   Texas Health Science Center at San Antonio; University of Texas System;
   University of Texas Health Science Center at San Antonio; Texas
   Biomedical Research Institute; Texas Biomedical Research Institute;
   University of Texas System; University of Texas Health Science Center at
   San Antonio
RP Asmis, R (corresponding author), Univ Texas Hlth Sci Ctr San Antonio, Dept Radiol, San Antonio, TX 78229 USA.; Asmis, R (corresponding author), Univ Texas Hlth Sci Ctr San Antonio, Dept Biochem & Struct Biol, San Antonio, TX 78229 USA.; Asmis, R (corresponding author), Univ Texas Hlth Sci Ctr San Antonio, Dept Clin Lab Sci, San Antonio, TX 78229 USA.
EM asmis@uthscsa.edu
RI , Sina/ACP-9331-2022; Asmis, Reto/W-1344-2019
OI Cox, Laura/0000-0002-8836-3783
FU NIH [HL70963, AT006885, NCI P30 CA054174]; Southwest National Primate
   Research Center; Texas Biomedical Research Institute [C06 RR013556, C06
   RR017515]; Flow Cytometry Facility at UT Health San Antonio
FX This work was supported by grants to RA from the NIH (HL70963 and
   AT006885) and pilot funds to RA, JS, and LC from the Southwest National
   Primate Research Center. The Texas Biomedical Research Institute
   facilities were supported, in part, from NIH Research Facilities
   Improvement Program Grants C06 RR013556 and C06 RR017515, and the Flow
   Cytometry Facility at UT Health San Antonio was supported with funding
   from the University and the NIH (NCI P30 CA054174). The authors wish to
   thank Dr. Melissa de la Garza and the team of veterinary research
   technicians at the SNPRC and the Pathology Core Facility at the Texas
   Biomedical Research Institute for their technical assistance in
   collecting blood and performing blood analyses. The authors also wish to
   thank Jessica Han, Kevin Downs, and Yong Joo Ahn for technical
   assistance and in writing the manuscript. Lastly, the authors would like
   to thank Dr. Benjamin Daniel and Karla Moncada of the Flow Cytometry
   Facility at UT Health San Antonio for technical assistance.
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NR 52
TC 20
Z9 22
U1 0
U2 6
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA PO BOX 110, EPFL INNOVATION PARK, BUILDING I, LAUSANNE, 1015,
   SWITZERLAND
SN 1664-3224
J9 FRONT IMMUNOL
JI Front. Immunol.
PD AUG 22
PY 2017
VL 8
AR 958
DI 10.3389/fimmu.2017.00958
PG 13
WC Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology
GA FE4CU
UT WOS:000408162800001
PM 28878765
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Pacheco, FJ
   Almaguel, FG
   Evans, W
   Rios-Colon, L
   Filippov, V
   Leoh, LS
   Rook-Arena, E
   Mediavilla-Varela, M
   De Leon, M
   Casiano, CA
AF Pacheco, Fabio J.
   Almaguel, Frankis G.
   Evans, Whitney
   Rios-Colon, Leslimar
   Filippov, Valery
   Leoh, Lai S.
   Rook-Arena, Elizabeth
   Mediavilla-Varela, Melanie
   De Leon, Marino
   Casiano, Carlos A.
TI Docosahexanoic acid antagonizes TNF-α-induced necroptosis by attenuating
   oxidative stress, ceramide production, lysosomal dysfunction, and
   autophagic features
SO INFLAMMATION RESEARCH
LA English
DT Article
DE DHA; L929 cells; Lysosomes; Necroptosis; Oxidative stress; Inflammation;
   TNF-alpha
ID POLYUNSATURATED FATTY-ACIDS; PROSTATE-CANCER RISK; DNA TOPOISOMERASE-I;
   CELL-DEATH; L929 CELLS; SECONDARY NECROSIS; METABOLIC SYNDROME;
   CATHEPSIN-L; CLEAVAGE; ACTIVATION
AB It was previously reported that docosahexanoic acid (DHA) reduces TNF-alpha-induced necrosis in L929 cells. However, the mechanisms underlying this reduction have not been investigated. The present study was designed to investigate cellular and biochemical mechanisms underlying the attenuation of TNF-alpha-induced necroptosis by DHA in L929 cells.
   L929 cells were pre-treated with DHA prior to exposure to TNF-alpha, zVAD, or Necrostatin-1 (Nec-1). Cell death and survival were assessed by MTT and caspase activity assays, and microscopic visualization. Reactive oxygen species (ROS) were measured by flow cytometry. C16- and C18-ceramides were measured by mass spectrometry. Lysosomal membrane permeabilization (LMP) was evaluated by fluorescence microscopy and flow cytometry using Acridine Orange. Cathepsin L activation was evaluated by immunoblotting and fluorescence microscopy. Autophagy was assessed by immunoblotting of LC3-II and Beclin.
   Exposure of L929 cells to TNF-alpha alone for 24 h induced necroptosis, as evidenced by the inhibition of cell death by Nec-1, absence of caspase-3 activity and Lamin B cleavage, and morphological analysis. DHA attenuated multiple biochemical events associated with TNF-alpha-induced necroptosis, including ROS generation, ceramide production, lysosomal dysfunction, cathepsin L activation, and autophagic features. DHA also attenuated zVAD-induced necroptosis but did not attenuate the enhanced apoptosis and necrosis induced by the combination of TNF-alpha with Actinomycin D or zVAD, respectively, suggesting that its protective effects might be limited by the strength of the cell death insult induced by TNF-alpha.
   DHA effectively attenuates TNF-alpha-induced necroptosis and autophagy, most likely via its ability to inhibit TNF-alpha-induced sphingolipid metabolism and oxidative stress. These results highlight the role of this Omega-3 fatty acid in antagonizing inflammatory cell death.
C1 [Pacheco, Fabio J.; Almaguel, Frankis G.; Evans, Whitney; Rios-Colon, Leslimar; Filippov, Valery; Leoh, Lai S.; Rook-Arena, Elizabeth; Mediavilla-Varela, Melanie; De Leon, Marino] Loma Linda Univ, Sch Med, Ctr Hlth Dispar & Mol Med, Loma Linda, CA 92350 USA.
   [Pacheco, Fabio J.; Almaguel, Frankis G.; Evans, Whitney; Rios-Colon, Leslimar; Filippov, Valery; Leoh, Lai S.; Rook-Arena, Elizabeth; Mediavilla-Varela, Melanie; De Leon, Marino; Casiano, Carlos A.] Loma Linda Univ, Sch Med, Dept Basic Sci, Loma Linda, CA 92350 USA.
   [Pacheco, Fabio J.] River Plate Adventist Univ, Sch Hlth Sci, Fac Med, Puiggari, Entre Rios, Argentina.
   [Rook-Arena, Elizabeth; Casiano, Carlos A.] Loma Linda Univ, Sch Med, Dept Med, Div Rheumatol, Loma Linda, CA 92350 USA.
C3 Loma Linda University; Loma Linda University; Loma Linda University
RP Casiano, CA (corresponding author), Loma Linda Univ, Sch Med, Ctr Hlth Dispar & Mol Med, Loma Linda, CA 92350 USA.
EM ccasiano@llu.edu
RI Filippov, Valeri/LFS-7398-2024; De Leon, Marino/A-6922-2009
OI De Leon, Marino/0000-0001-6576-785X
FU NIH [5P20MD006988, 5P20MD001632, 5R25GM060507]
FX We are grateful to Leanna Ursales, Teka-Ann Haynes, Anamika Basu, Tino
   Sanchez, and other members of the Casiano and De Leon laboratories for
   their technical and editorial assistance. This work was supported by NIH
   grants 5P20MD006988 (MDL and CAC), 5P20MD001632 (MDL and CAC), and
   5R25GM060507 (MDL).
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NR 62
TC 41
Z9 46
U1 1
U2 28
PU SPRINGER BASEL AG
PI BASEL
PA PICASSOPLATZ 4, BASEL, 4052, SWITZERLAND
SN 1023-3830
EI 1420-908X
J9 INFLAMM RES
JI Inflamm. Res.
PD OCT
PY 2014
VL 63
IS 10
BP 859
EP 871
DI 10.1007/s00011-014-0760-2
PG 13
WC Cell Biology; Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Immunology
GA AP2PO
UT WOS:000341916000007
PM 25095742
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Kuperman, Y
   Issler, O
   Vaughan, J
   Bilezikjian, L
   Vale, W
   Chen, A
AF Kuperman, Yael
   Issler, Orna
   Vaughan, Joan
   Bilezikjian, Louise
   Vale, Wylie
   Chen, Alon
TI Expression and Regulation of Corticotropin-Releasing Factor Receptor
   Type 2β in Developing and Mature Mouse Skeletal Muscle
SO MOLECULAR ENDOCRINOLOGY
LA English
DT Article
ID MESSENGER-RNA EXPRESSION; INSULIN-RESISTANCE; HORMONE-RECEPTOR;
   UROCORTIN-II; SERUM RETINOL-BINDING-PROTEIN-4; VENTROMEDIAL
   HYPOTHALAMUS; CARDIOVASCULAR-SYSTEM; NERVOUS-SYSTEM; CHRONIC STRESS; CRF
   RECEPTORS
AB Corticotropin-releasing factor receptor type 2 (CRFR2) is highly expressed in skeletal muscle (SM) tissue where it is suggested to inhibit interactions between insulin signaling pathway components affecting whole-body glucose homeostasis. However, little is known about factors regulating SM CRFR2 expression. Here, we demonstrate the exclusive expression of CRFR2, and not CRFR1, in mature SM tissue using RT-PCR and ribonuclease protection assays and report a differential expression of CRF receptors during C2C12 myogenic differentiation. Whereas C2C12 myoblasts exclusively express CRFR1, the C2C12 myotubes solely express CRFR2. Using cAMP luciferase assays and calcium mobilization measurements, we further demonstrate the functionality of these differentially expressed receptors. Using luciferase reporter assays we show a differential activation of CRFR promoters during myogenic differentiation. Transfections with different fragments of the 5'-flanking region of the mCRFR2 beta gene fused to a luciferase reporter gene show a promoter-dependent expression of the reporter gene and reveal the importance of the myocyte enhancer factor 2 consensus sequence located at the 3'-proximal region of CRFR2 beta promoter. Furthermore, we demonstrate that CRFR2 gene transcription in the mature mouse is stimulated by both high-fat diet and chronic variable stress conditions. Performing a whole-genome expression microarray analysis of SM tissues obtained from CRFR2-null mice or wild-type littermates revealed a robust reduction in retinol-binding protein 4 expression levels, an adipokine whose serum levels are elevated in insulin-resistant states. In correlation with the SM CRFR2 beta levels, the SM retinol-binding protein 4 levels were also elevated in mice subjected to high-fat diet and chronic variable stress conditions. The current findings further position the SM CRFR2 pathways as a relevant physiological system that may affect the known reciprocal relationship between psychological and physiological challenges and the metabolic syndrome. (Molecular Endocrinology 25: 157-169, 2011)
C1 [Kuperman, Yael; Issler, Orna; Chen, Alon] Weizmann Inst Sci, Dept Neurobiol, IL-76100 Rehovot, Israel.
   [Vaughan, Joan; Bilezikjian, Louise; Vale, Wylie] Salk Inst Biol Studies, Clayton Fdn Labs Peptide Biol, La Jolla, CA 92037 USA.
C3 Weizmann Institute of Science; Salk Institute
RP Chen, A (corresponding author), Weizmann Inst Sci, Dept Neurobiol, IL-76100 Rehovot, Israel.
EM alon.chen@weizmann.ac.il
OI Chen, Alon/0000-0003-3625-8233; Issler, Orna/0000-0003-1473-8295
FU Clayton Medical Research Foundation, Inc.; Roberto and Renata Ruhman,
   Brazil; Mark Besen and the Pratt Foundation, Australia; Israel Science
   Foundation; Legacy Heritage Biomedical Science Partnership; Nella and
   Leon Benoziyo Center for Neurosciences; Nella and Leon Benoziyo Center
   for Neurological Diseases; Carl and Micaela Einhorn-Dominic Brain
   Research Institute; Irwin Green Alzheimer; Gerhard and Hannah Bacharach
   (Fort Lee, NJ); National Institute of Diabetes and Digestive and Kidney
   Diseases [5P01DK026741-30]
FX This research was supported in part by the Clayton Medical Research
   Foundation, Inc. A.C. was supported by the following: Roberto and Renata
   Ruhman, Brazil; Mark Besen and the Pratt Foundation, Australia; the
   Israel Science Foundation; the Legacy Heritage Biomedical Science
   Partnership D-Cure Fellowship; Nella and Leon Benoziyo Center for
   Neurosciences; Nella and Leon Benoziyo Center for Neurological Diseases;
   Carl and Micaela Einhorn-Dominic Brain Research Institute; Irwin Green
   Alzheimer's Research Fund; Gerhard and Hannah Bacharach (Fort Lee, NJ)
   and is incumbent of the Philip Harris and Gerald Ronson Career
   Development Chair. W.V. was supported by Award No. 5P01DK026741-30 from
   the National Institute of Diabetes and Digestive and Kidney Diseases and
   is a Clayton Medical Research Foundation, Inc. Senior Investigator and
   the Helen McLoraine Professor of Molecular Neurobiology.
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NR 67
TC 16
Z9 21
U1 0
U2 7
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0888-8809
EI 1944-9917
J9 MOL ENDOCRINOL
JI Mol. Endocrinol.
PD JAN
PY 2011
VL 25
IS 1
BP 157
EP 169
DI 10.1210/me.2010-0308
PG 13
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 700MD
UT WOS:000285745800013
PM 21084379
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU He, LX
   Zhao, J
   Huang, YS
   Li, Y
AF He, Li-xia
   Zhao, Jian
   Huang, Yuan-sheng
   Li, Yong
TI The difference between oats and beta-glucan extract intake in the
   management of HbA1c, fasting glucose and insulin sensitivity: a
   meta-analysis of randomized controlled trials
SO FOOD & FUNCTION
LA English
DT Article
ID BLOOD-PRESSURE; SERUM-LIPIDS; POSTPRANDIAL GLUCOSE; METABOLIC SYNDROME;
   OXIDATIVE STRESS; DIETARY FIBER; BRAN; CHOLESTEROL; CONSUMPTION;
   RESPONSES
AB Increasing oats and beta-glucan extract intake has been associated with improved glycemic control, which is associated with the reduction in the development of diabetes. This study aims to assess the different effects between oat (whole and bran) and beta-glucan extract intake on glycemic control and insulin sensitivity. PubMed, Embase, Medline, The Cochrane Library, CINAHL and Web of Science were searched up to February 2014. We included randomized controlled trials with interventions that lasted at least four weeks that compared oats and beta-glucan (extracted from oats or other sources) intake with a control. A total of 1351 articles were screened for eligibility, and relevant data were extracted from 18 studies (n = 1024). Oat product dose ranged from 20 g d(-1) to 136 g d(-1), and beta-glucan extract dose ranged from 3 g d(-1) to 10 g d(-1). Compared with the control, oat intake resulted in a greater decrease in fasting glucose and insulin of subjects (P < 0.05), but beta-glucan extract intake did not. Furthermore, oat intake resulted in a greater decrease in glycosylated hemoglobin (HbA1c) (P < 0.001, I-2 = 0%) and fasting glucose (P < 0.001, I-2 = 68%) after removing one study using a concentrate and a different design and fasting insulin of type 2 diabetes (T2D) (P < 0.001, I-2 = 0%). The intake of oats and beta-glucan extracted from oats were effective in decreasing fasting glucose (P = 0.007, I-2 = 91%) and fasting insulin of T2D (P < 0.001, I-2 = 0%) and tented to lower HbA1c (P = 0.09, I-2 = 92%). Higher consumption of whole oats and oat bran, but not oat or barley beta-glucan extracts, are associated with lower HbA1c, fasting glucose and fasting insulin of T2D, hyperlipidaemic and overweight subjects, especially people with T2D, which supports the need for clinical trials to evaluate the potential role of oats in approaching to the management of glycemic control and insulin sensitivity of diabetes or metabolic syndrome subjects.
C1 [He, Li-xia; Li, Yong] Peking Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Beijing 100871, Peoples R China.
   [He, Li-xia; Li, Yong] Peking Univ, Beijing Key Lab Toxicol Res & Risk Assessment Foo, Beijing 100871, Peoples R China.
   [Zhao, Jian] Nanjing Agr Univ, Coll Vet Med, Nanjing, Jiangsu, Peoples R China.
   [Huang, Yuan-sheng] Peking Univ, Sch Publ Hlth, Dept Empidemiol & Biostat, Beijing 100871, Peoples R China.
C3 Peking University; Peking University; Nanjing Agricultural University;
   Peking University
RP Li, Y (corresponding author), Peking Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Beijing 100871, Peoples R China.; Li, Y (corresponding author), Peking Univ, Beijing Key Lab Toxicol Res & Risk Assessment Foo, Beijing 100871, Peoples R China.
EM helixiapku@163.com; stylezhaojian@163.com; huangshensd16@126.com;
   liyongbmu@163.com
OI He, Lixia/0000-0001-9725-8398
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NR 55
TC 56
Z9 62
U1 0
U2 53
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PY 2016
VL 7
IS 3
BP 1413
EP 1428
DI 10.1039/c5fo01364j
PG 16
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA DG7FZ
UT WOS:000372251500018
PM 26840185
DA 2025-06-11
ER

PT J
AU McAvoy, NC
   Kochar, N
   Mckillop, G
   Newby, DE
   Hayes, PC
AF McAvoy, Norma C.
   Kochar, Narendra
   Mckillop, Graham
   Newby, David E.
   Hayes, Peter C.
TI Prevalence of Coronary Artery Calcification in Patients Undergoing
   Assessment for Orthotopic Liver Transplantation
SO LIVER TRANSPLANTATION
LA English
DT Article
ID DOBUTAMINE STRESS ECHOCARDIOGRAPHY; STAGE RENAL-DISEASE;
   INSULIN-RESISTANCE; CALCIUM SCORE; RISK-FACTORS; EVENTS; MODEL;
   TOMOGRAPHY; PREDICTION; MORTALITY
AB Patients with advanced liver disease are at increased risk of cardiovascular events, especially following orthotopic liver transplantation (OLT). Coronary artery calcification (CAC) is a novel and independent predictor of cardiovascular risk, but its prevalence and utility in patients with cirrhosis are unknown. The aim of this study was to define the prevalence of CAC and its association with markers of disease severity and standard measures of cardiovascular risk in a large cohort of patients undergoing OLT assessment. A single-center, prospective, observational study of 147 consecutive patients undergoing assessment for OLT was performed. CAC scores were derived with the Agatston method from thoracic computed tomography scans and correlated with cardiovascular risk factors and measures of liver disease severity. There were 101 patients (66 males) with a mean age of 53.2 years; 46 patients were excluded because the CAC score was not reported. The median CAC score was 40 HU (range, 0-3533). Correlations were identified between the CAC score and age (r = 0.477; P < 0.001), male sex (r = 0.262; P = 0.008), family history of cardiovascular disease (r = 0.208; P = 0.036), Framingham risk score (r = 0.621; P < 0.001), Model for End-Stage Liver Disease score (r = 0.221; P = 0.027), systolic blood pressure (r = 0.285; P = 0.004), diastolic blood pressure (r = 0.267; P = 0.007), cytomegalovirus status (r = 0.278; P = 0.005), fasting glucose (r = 0.330; P = 0.001), number of coronary vessels involved (r = 0.899; P < 0.001), and components of the metabolic syndrome (r = 0.226; P = 0.026). After multivariate analysis, age, systolic blood pressure, fasting glucose, number of features of metabolic syndrome, and number of vessels involved remained significantly associated with CAC. In conclusion, this study identified a high prevalence of occult coronary artery disease in patients undergoing OLT assessment and identified a strong relationship between CAC scores and a limited number of specific cardiovascular risk factors. The usefulness of these factors in predicting perioperative and postoperative cardiovascular events in patients undergoing OLT requires prospective evaluation. Liver Transpl 14.1725-1731, 2008. (C) 2008 AASLD.
C1 [McAvoy, Norma C.; Kochar, Narendra; Hayes, Peter C.] Royal Infirm Edinburgh NHS Trust, Dept Hepatol, Edinburgh EH16 4SA, Midlothian, Scotland.
   [Mckillop, Graham] Royal Infirm Edinburgh NHS Trust, Dept Radiol, Edinburgh EH16 4SA, Midlothian, Scotland.
   [Newby, David E.] Royal Infirm Edinburgh NHS Trust, Dept Cardiol, Edinburgh EH16 4SA, Midlothian, Scotland.
C3 University of Edinburgh; Royal Infirmary of Edinburgh; Royal Infirmary
   of Edinburgh; University of Edinburgh; University of Edinburgh; Royal
   Infirmary of Edinburgh
RP McAvoy, NC (corresponding author), Royal Infirm Edinburgh NHS Trust, Dept Hepatol, 51 Little France Crescent, Edinburgh EH16 4SA, Midlothian, Scotland.
EM norma.mcavoy@ed.ac.uk
RI Newby, David/AAB-1364-2019
OI Newby, David/0000-0001-7971-4628
FU British Heart Foundation [PG/06/126/21673]
FX This work was supported by a project grant from the British Heart
   Foundation (PG/06/126/21673).
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NR 34
TC 75
Z9 76
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1527-6465
EI 1527-6473
J9 LIVER TRANSPLANT
JI Liver Transplant.
PD DEC
PY 2008
VL 14
IS 12
BP 1725
EP 1731
DI 10.1002/lt.21540
PG 7
WC Gastroenterology & Hepatology; Surgery; Transplantation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery; Transplantation
GA 382KL
UT WOS:000261604600005
PM 19025916
DA 2025-06-11
ER

PT J
AU Tenenbaum, A
   Klempfner, R
   Fisman, EZ
AF Tenenbaum, Alexander
   Klempfner, Robert
   Fisman, Enrique Z.
TI Hypertriglyceridemia: a too long unfairly neglected major cardiovascular
   risk factor
SO CARDIOVASCULAR DIABETOLOGY
LA English
DT Review
DE Cardiovascular risk; Cholesterol; Fibrates; Hypertriglyceridemia;
   Insulin resistance; Metabolic syndrome; Obesity; Statins; Triglycerides;
   Type 2 diabetes
ID FREE FATTY-ACIDS; CORONARY-HEART-DISEASE; TRIGLYCERIDE-RICH
   LIPOPROTEINS; APOLIPOPROTEIN-C-III; ENDOPLASMIC-RETICULUM STRESS;
   HIGH-DENSITY-LIPOPROTEINS; TYPE-2 DIABETIC-PATIENTS; GLUT4
   GENE-EXPRESSION; ALL-CAUSE MORTALITY; PROTEIN-KINASE-C
AB The existence of an independent association between elevated triglyceride (TG) levels, cardiovascular (CV) risk and mortality has been largely controversial. The main difficulty in isolating the effect of hypertriglyceridemia on CV risk is the fact that elevated triglyceride levels are commonly associated with concomitant changes in high density lipoprotein (HDL), low density lipoprotein (LDL) and other lipoproteins. As a result of this problem and in disregard of the real biological role of TG, its significance as a plausible therapeutic target was unfoundedly underestimated for many years. However, taking epidemiological data together, both moderate and severe hypertriglyceridaemia are associated with a substantially increased long term total mortality and CV risk. Plasma TG levels partially reflect the concentration of the triglyceride-carrying lipoproteins (TRL): very low density lipoprotein (VLDL), chylomicrons and their remnants. Furthermore, hypertriglyceridemia commonly leads to reduction in HDL and increase in atherogenic small dense LDL levels. TG may also stimulate atherogenesis by mechanisms, such excessive free fatty acids (FFA) release, production of proinflammatory cytokines, fibrinogen, coagulation factors and impairment of fibrinolysis. Genetic studies strongly support hypertriglyceridemia and high concentrations of TRL as causal risk factors for CV disease. The most common forms of hypertriglyceridemia are related to overweight and sedentary life style, which in turn lead to insulin resistance, metabolic syndrome (MS) and type 2 diabetes mellitus (T2DM). Intensive lifestyle therapy is the main initial treatment of hypertriglyceridemia. Statins are a cornerstone of the modern lipids-modifying therapy. If the primary goal is to lower TG levels, fibrates (bezafibrate and fenofibrate for monotherapy, and in combination with statin; gemfibrozil only for monotherapy) could be the preferable drugs. Also ezetimibe has mild positive effects in lowering TG. Initial experience with en ezetimibe/fibrates combination seems promising. The recently released IMPROVE-IT Trial is the first to prove that adding a non-statin drug (ezetimibe) to a statin lowers the risk of future CV events. In conclusion, the classical clinical paradigm of lipids-modifying treatment should be changed and high TG should be recognized as an important target for therapy in their own right. Hypertriglyceridemia should be treated.
C1 [Tenenbaum, Alexander; Klempfner, Robert] Sheba Med Ctr, Cardiac Rehabil Inst, IL-52621 Tel Hashomer, Israel.
   [Tenenbaum, Alexander; Klempfner, Robert; Fisman, Enrique Z.] Tel Aviv Univ, Sackler Fac Med, IL-69978 Tel Aviv, Israel.
   [Tenenbaum, Alexander; Fisman, Enrique Z.] Cardiovasc Diabetol Res Fdn, IL-58484 Holon, Israel.
C3 Chaim Sheba Medical Center; Tel Aviv University; Tel Aviv University;
   Sackler Faculty of Medicine
RP Tenenbaum, A (corresponding author), Sheba Med Ctr, Cardiac Rehabil Inst, IL-52621 Tel Hashomer, Israel.
EM altenen@post.tau.ac.il
RI Klempfner, Robert/M-4989-2016; Fisman, Enrique/ABV-2830-2022
FU Cardiovascular Diabetology Research Foundation, Holon, Israel [RA
   58-040-684-1]
FX This work was supported by the Cardiovascular Diabetology Research
   Foundation (RA 58-040-684-1), Holon, Israel.
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NR 174
TC 135
Z9 145
U1 0
U2 60
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1475-2840
J9 CARDIOVASC DIABETOL
JI Cardiovasc. Diabetol.
PD DEC 4
PY 2014
VL 13
AR 159
DI 10.1186/s12933-014-0159-y
PG 10
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism
GA AW1QY
UT WOS:000346065600001
PM 25471221
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Artacho-Cordón, F
   León, J
   Sáenz, JM
   Fernández, MF
   Martin-Olmedo, P
   Olea, N
   Arrebola, JP
AF Artacho-Cordon, Francisco
   Leon, Josefa
   Saenz, Jose M.
   Fernandez, Mariana F.
   Martin-Olmedo, Piedad
   Olea, Nicolas
   Arrebola, Juan P.
TI Contribution of Persistent Organic Pollutant Exposure to the Adipose
   Tissue Oxidative Microenvironment in an Adult Cohort: A Multipollutant
   Approach
SO ENVIRONMENTAL SCIENCE & TECHNOLOGY
LA English
DT Article
ID SOUTHERN SPAIN; BREAST-CANCER; FREE-RADICALS; POLYCHLORINATED-BIPHENYLS;
   RAT-LIVER; ORGANOCHLORINE PESTICIDES; EXERCISE INTERVENTION;
   LIPID-PEROXIDATION; METABOLIC SYNDROME; STRESS
AB Despite growing in vitro and in vivo evidence of the putative role of persistent organic pollutants (POPs) in the induction of oxidative damage in cell structures, this issue has been poorly addressed from an epidemiologic perspective. The aim of this study was to explore associations between adipose tissue POP concentrations and the in situ oxidative microenvironment. A cross-sectional study was conducted in a subsample (n = 271) of a previously established cohort, quantifying levels of eight POPs and four groups of oxidative stress biomarkers in adipose tissue. Associations were explored using multivariate linear regression analyses adjusted for potential confounders. We assessed the combined effect of POPs on oxidative stress/glutathione system biomarkers using weighted quantile sum regression (WQS). Increased concentrations of p,p'-DDE, HCB, beta-HCH, dicofol, and PCBs (congeners -138, -153, and -180) were predominantly associated with higher lipid peroxidation (TBARS) [exp(beta) = 1.09-1.78, p < 0.01-0.04)] and SOD activity [exp(beta) = 1.13-1.48, p < 0.01-0.05)] levels. However, only a few associations were observed with glutathione system biomarkers, e.g., PCB-180 with total glutathione [exp(beta) = 1.98, p = 0.03]. The WQS index was found to be positively associated with SOD activity, and PCB-138, PCB-180, and beta-HCH were the main contributors to the index. Likewise, the WQS index was positively associated with TBARS levels, with the three PCBs acting as the main contributors. This is the first epidemiological evidence of the putative disruption by POPs of the adipose tissue oxidative microenvironment. Our results indicate that POP exposure may enhance alternative pathways to the glutathione detoxification route, which might result in tissue damage. Further research is warranted to fully elucidate the potential health implications.
C1 [Artacho-Cordon, Francisco; Fernandez, Mariana F.; Olea, Nicolas] Univ Granada, Radiol & Phys Med Dept, Granada 18012, Spain.
   [Artacho-Cordon, Francisco; Leon, Josefa; Saenz, Jose M.; Fernandez, Mariana F.; Olea, Nicolas; Arrebola, Juan P.] Hosp Univ Granada, Inst Invest Biosanitaria ibsGRANADA, Granada 18012, Spain.
   [Leon, Josefa] CIBER Enfermedades Hepat & Digest CIBEREHD, Madrid 28029, Spain.
   [Fernandez, Mariana F.; Olea, Nicolas] CIBER Epidemiol & Salud Publ CIBERESP, Madrid 28029, Spain.
   [Martin-Olmedo, Piedad; Arrebola, Juan P.] Escuela Andaluza Salud Publ, Granada 18011, Spain.
   [Arrebola, Juan P.] Virgen Nieves Univ Hosp, Oncol Unit, Granada 18012, Spain.
C3 University of Granada; Instituto de Investigacion Biosanitaria IBS
   Granada; University of Granada; CIBER - Centro de Investigacion
   Biomedica en Red; CIBEREHD; CIBER - Centro de Investigacion Biomedica en
   Red; CIBERESP; Escuela Andaluza de Salud Publica; Hospital Universitario
   Virgen de las Nieves
RP Arrebola, JP (corresponding author), Hosp Univ Granada, Inst Invest Biosanitaria ibsGRANADA, Granada 18012, Spain.; Arrebola, JP (corresponding author), Escuela Andaluza Salud Publ, Granada 18011, Spain.; Arrebola, JP (corresponding author), Virgen Nieves Univ Hosp, Oncol Unit, Granada 18012, Spain.
EM jparrebola@ugr.es
RI Arrebola, Juan/A-5205-2017; Leon, Pepi/K-8972-2014; Fernandez, Mariana
   F/C-9877-2012; Olea, Nicolas/H-3198-2014; Artacho-Cordon,
   Francisco/A-3166-2015
OI Fernandez, Mariana F/0000-0001-6417-8914; Olea,
   Nicolas/0000-0002-8938-3743; MARTIN-OLMEDO, PIEDAD/0000-0002-3343-9760;
   Arrebola, Juan P./0000-0002-8643-2423; Artacho-Cordon,
   Francisco/0000-0003-3850-6173
FU Spanish Ministry of Education [FPU12/02524]; Institute of Health Carlos
   III [CP15/00193]; European Union Commission [H2020-EJP-HBM4EU,
   SOE1/P1/F0082]; Institute of Health Carlos III Spanish Ministry of
   Health (Biomedical Research Networking Center CIBERESP) [EF-0708-2013,
   FIS-PI13/02406, FIS-PI14/00067, FIS-PI16/01820, FIS-PI16/01812,
   FIS-PI16/01858]
FX The results would not have been achieved without the selfless
   collaboration of the patients who took part in the study. The authors
   gratefully acknowledge scientific and technical assistance provided by
   Richard Davies. F.A.C. has a fellowship from the Spanish Ministry of
   Education (FPU12/02524). Further the authors are grateful to Institute
   of Health Carlos III for the research contract (Miguel Servet Type I
   Program CP15/00193 granted to J.P.A.). This research was funded by
   grants from the European Union Commission (H2020-EJP-HBM4EU and
   SOE1/P1/F0082) and from the Institute of Health Carlos III Spanish
   Ministry of Health (Biomedical Research Networking Center CIBERESP,
   EF-0708-2013, FIS-PI13/02406, FIS-PI14/00067, FIS-PI16/01820,
   FIS-PI16/01812 and FIS-PI16/01858).
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NR 77
TC 42
Z9 43
U1 1
U2 47
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0013-936X
EI 1520-5851
J9 ENVIRON SCI TECHNOL
JI Environ. Sci. Technol.
PD DEC 20
PY 2016
VL 50
IS 24
BP 13529
EP 13538
DI 10.1021/acs.est.6b03783
PG 10
WC Engineering, Environmental; Environmental Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering; Environmental Sciences & Ecology
GA EF8ZQ
UT WOS:000390620900042
PM 27993081
DA 2025-06-11
ER

PT J
AU Sun, XW
   Feng, RN
   Li, YC
   Lin, S
   Zhang, W
   Li, Y
   Sun, CH
   Li, ST
AF Sun, Xiaowei
   Feng, Rennan
   Li, Yanchuan
   Lin, Song
   Zhang, Wei
   Li, Ying
   Sun, Changhao
   Li, Songtao
TI Histidine supplementation alleviates inflammation in the adipose tissue
   of high-fat diet-induced obese rats via the NF-κB- and PPARγ-involved
   pathways
SO BRITISH JOURNAL OF NUTRITION
LA English
DT Article
DE Histidine; High-fat diets; Obesity; Inflammation
ID PROLIFERATOR-ACTIVATED RECEPTOR; LOW-DENSITY-LIPOPROTEIN; SUPPRESSES
   FOOD-INTAKE; INSULIN-RESISTANCE; OXIDATIVE STRESS; METABOLIC SYNDROME;
   CARNOSINE; ADIPONECTIN; EXPRESSION; ASSOCIATIONS
AB Obesity is considered to be accompanied by a chronic low-grade inflammatory state that contributes to the occurrence of many chronic diseases. Our previous study has demonstrated that histidine supplementation significantly ameliorates inflammation and oxidative stress in obese women. However, the in vivo potential mechanisms are not known. The present study was conducted to investigate the mechanisms underlying the effects of histidine on inflammation in a high-fat diet (HFD)-induced female obese rat model. An obese model was established in female Sprague-Dawley rats by HFD feeding for 8 weeks and followed by histidine supplementation for another 4 weeks. The results revealed that HFD-increased body weight and HFD-lowered serum histidine concentrations were significantly reversed by histidine supplementation (P<0.05). In addition, the serum concentrations of TNF-alpha, IL-6, C-reactive protein (CRP) and malondialdehyde were significantly reduced and those of superoxide dismutase (SOD) were significantly increased by histidine supplementation when compared with those in obese rats (P<0.05). Correspondingly, the mRNA expressions of TNF-alpha, IL-6 and CRP in the adipose tissue were significantly down-regulated and that of CuZnSOD was significantly up-regulated by histidine supplementation (P<0.05). Histidine supplementation significantly reduced the HFD-induced translocation of NF-kappa B p65 into the nucleus (P=0.032) by reducing the phosphorylation of the inhibitor of kappa B alpha in the adipose tissue. The results also revealed that the expression of adiponectin was markedly increased both in the serum and in the adipose tissue after histidine supplementation, accompanied by the activation of PPAR gamma (P=0.021). These findings indicate that histidine is an effective candidate for ameliorating inflammation and oxidative stress in obese individuals via the NF-kappa B-and PPAR gamma-involved pathways.
C1 [Sun, Xiaowei; Feng, Rennan; Li, Yanchuan; Lin, Song; Zhang, Wei; Li, Ying; Sun, Changhao; Li, Songtao] Harbin Med Univ, Coll Publ Hlth, Dept Nutr & Food Hyg, Harbin 150081, Heilongjiang Pr, Peoples R China.
C3 Harbin Medical University
RP Li, ST (corresponding author), Harbin Med Univ, Coll Publ Hlth, Dept Nutr & Food Hyg, 157 Baojian Rd, Harbin 150081, Heilongjiang Pr, Peoples R China.
EM lisongtaoklds@126.com
RI Li, Songtao/I-1490-2019; Li, Yanchuan/AGX-9749-2022; Sun,
   Xiao/U-3439-2017
FU National Natural Science Fund of China [81130049, 81202184]; 12th China
   Five-Year Scientific and Technical Plan [2012BAI02B00]; Research Fund
   for Innovation Talents of Science and Technology in Harbin City
   [2013RFQXJ068]
FX The present study was supported by the National Natural Science Fund of
   China (81130049 and 81202184), the 12th China Five-Year Scientific and
   Technical Plan (grant no. 2012BAI02B00), and the Research Fund for
   Innovation Talents of Science and Technology in Harbin City
   (2013RFQXJ068).
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NR 43
TC 58
Z9 60
U1 2
U2 34
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1145
EI 1475-2662
J9 BRIT J NUTR
JI Br. J. Nutr.
PD AUG 28
PY 2014
VL 112
IS 4
BP 477
EP 485
DI 10.1017/S0007114514001056
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA AN4QD
UT WOS:000340571800001
PM 24833547
OA Bronze
DA 2025-06-11
ER

PT J
AU Zhang, XM
   Wang, ZG
   Li, JX
   Gu, DF
   Li, ST
   Shen, C
   Song, ZY
AF Zhang, Ximei
   Wang, Zhigang
   Li, Jiaxin
   Gu, Dongfang
   Li, Songtao
   Shen, Chen
   Song, Zhenyuan
TI Increased 4-Hydroxynonenal Formation Contributes to Obesity-Related
   Lipolytic Activation in Adipocytes
SO PLOS ONE
LA English
DT Article
ID HORMONE-SENSITIVE LIPASE; ENDOPLASMIC-RETICULUM STRESS; PROTEIN-KINASE
   CASCADE; OXIDATIVE STRESS; POTENTIAL MECHANISM; METABOLIC SYNDROME;
   3T3-L1 ADIPOCYTES; GENE-EXPRESSION; PATHWAY; INSULIN
AB Oxidative stress in adipose tissue plays an etiological role in a variety of obesity-related metabolic disorders. We previously reported that increased adipose tissue 4-hydroxynonenal (4-HNE) contents contributed to obesity-related plasma adiponectin decline in mice. In the present study, we investigated the effects of intracellular 4-HNE accumulation on lipolytic response in adipocytes/adipose tissues and underlying mechanisms. In both fully-differentiated 3T3-L1 and primary adipocytes, a 5-hour 4-HNE exposure elevated lipolytic reaction in a dose-dependent manner at both basal and isoproterenol-stimulated conditions, evidenced by significantly increased glycerol and fatty acids releases. This conclusion was corroborated by the comparable observations when the minced human visceral adipose tissues were used. Mechanistic investigations revealed that 4-HNE-stimulated lipolytic activation is multifactorial. 4-HNE exposure quickly increased intracellular cyclic AMP (cAMP) level, which was concomitant with increased phosphorylations of protein kinase A (PKA) and its direct downstream target, hormone sensitive lipase (HSL). Pre-incubation with H89, a potent PKA inhibitor, prevented 4-HNE stimulated glycerol release, suggesting that enhanced lipolytic action in response to 4-HNE increase is mediated mainly by cAMP/PKA signal pathway in adipocytes. In addition to activating cAMP/PKA/HSL pathway, 4-HNE exposure also suppresses AMP-activated protein kinase (AMPK), a suppressive pathway for lipolysis, measured by both Western blotting for phosphorylated form of AMPK and ELISA for enzyme activity. Furthermore, 5-Aminoimidazole-4-carboxamide 1-beta-D-ribofuranoside (AICAR), a pharmacological AMPK activator, alleviated 4-HNE-induced lipolysis, suggesting that AMPK suppression also contributes to 4-HNE elicited lipolytic response. In conclusion, our findings indicate that increased intracellular 4-HNE accumulation in adipocytes/adipose tissues contributes to obesity-related lipolytic activation.
C1 [Zhang, Ximei; Wang, Zhigang; Li, Jiaxin; Gu, Dongfang; Li, Songtao; Shen, Chen; Song, Zhenyuan] Univ Illinois, Dept Kinesiol & Nutr, Chicago, IL 60607 USA.
   [Zhang, Ximei] Harbin Med Univ, Dept Histol & Embryol, Harbin, Heilongjiang, Peoples R China.
   [Song, Zhenyuan] Univ Illinois, Med Ctr, Dept Pathol, Chicago, IL USA.
C3 University of Illinois System; University of Illinois Chicago;
   University of Illinois Chicago Hospital; Harbin Medical University;
   University of Illinois System; University of Illinois Chicago;
   University of Illinois Chicago Hospital
RP Song, ZY (corresponding author), Univ Illinois, Dept Kinesiol & Nutr, Chicago, IL 60607 USA.
EM song2008@uic.edu
RI Li, Songtao/I-1490-2019; gu, dongfang/JDD-9133-2023
FU National Institutes of Health NIAAA [R01 AA017442]; 49th China
   Postdoctoral Science Foundation [20110491103]; National Natural Science
   Foundation of China [81000168]
FX National Institutes of Health NIAAA grants R01 AA017442 (Z Song); The
   49th China Postdoctoral Science Foundation: 20110491103 (X Zhang); The
   National Natural Science Foundation of China 81000168 (Z. Wang). The
   funders had no role in study design, data collection and analysis,
   decision to publish, or preparation of the manuscript.
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NR 47
TC 45
Z9 47
U1 0
U2 10
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD AUG 5
PY 2013
VL 8
IS 8
AR e70663
DI 10.1371/journal.pone.0070663
PG 10
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 218XC
UT WOS:000324465000112
PM 23940618
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Eliassen, BM
   Melhus, M
   Hansen, KL
   Broderstad, AR
AF Eliassen, Bent-Martin
   Melhus, Marita
   Hansen, Ketil Lenert
   Broderstad, Ann Ragnhild
TI Marginalisation and cardiovascular disease among rural Sami in Northern
   Norway: a population-based cross-sectional study
SO BMC PUBLIC HEALTH
LA English
DT Article
DE Cardiovascular disease; Marginalisation; Stress; Indigenous; Sami;
   SAMINOR; Norway
ID NORWEGIAN POPULATIONS; METABOLIC SYNDROME; LIVING-CONDITIONS; HEALTH;
   PREVALENCE; MORTALITY; AREAS
AB Background: Like other indigenous peoples, the Sami have been exposed to the huge pressures of colonisation, rapid modernisation and subsequent marginalisation. Previous studies among indigenous peoples show that colonialism, rapid modernisation and marginalisation is accompanied by increased stress, an unhealthy cardiovascular risk factor profile and disease burden. Updated data on the general burden of cardiovascular disease among the Sami is lacking. The primary objective of this study was to assess the relationship between marginalisation and self-reported lifetime cardiovascular disease (CVD) by minority/majority status in the rural Sami population of Norway.
   Methods: A cross-sectional population-based study (the SAMINOR study) was carried out in 2003-2004. The overall participation rate was 60.9% and a total of 4027 Sami individuals aged 36-79 years were included in the analyses. Data was collected by self-administrated questionnaires and a clinical examination.
   Results: The logistic regression showed that marginalised Sami living in Norwegian dominated areas were more than twice as likely to report CVD as non-marginalised Sami living in Sami majority areas (OR 2.10, 95% CI: 1.40-3.14). No sex difference was found in the effects of marginalisation on self-reported life-time cardiovascular disease. Moderate to no intermediate effects were seen after including established CVD risk factors.
   Conclusions: This study showed that marginalised Sami living in Norwegian dominated areas were more than twice as likely as non-marginalised Sami from Sami majority areas to report lifetime cardiovascular disease (CVD). Moderate to no intermediate effects were seen after including established CVD risk factors, which suggest little difference in lifestyle related factors. Chronic stress exposure following marginalisation may however be a plausible explanation for some of the observed excess of CVD.
C1 [Eliassen, Bent-Martin; Melhus, Marita; Hansen, Ketil Lenert; Broderstad, Ann Ragnhild] Univ Tromso, Fac Hlth Sci, Dept Community Med, Ctr Sami Hlth Res, N-9037 Tromso, Norway.
   [Broderstad, Ann Ragnhild] Univ Hosp Northern Norway, Dept Med, N-9480 Harstad, Norway.
C3 UiT The Arctic University of Tromso; UiT The Arctic University of
   Tromso; University Hospital of North Norway
RP Eliassen, BM (corresponding author), Univ Tromso, Fac Hlth Sci, Dept Community Med, Ctr Sami Hlth Res, N-9037 Tromso, Norway.
EM bent-martin.eliassen@uit.no
OI Hansen, Ketil Lenert/0000-0002-5092-9200
FU Norwegian Ministry of Health and Care Services
FX The Centre for Sami Health Research, University of Tromso conducted the
   survey in collaboration with the Norwegian Institute of Public Health.
   Funding was provided by the Norwegian Ministry of Health and Care
   Services. The authors thank Vigdis Stordahl and Svanhild Andersen for
   constructive comments on an earlier version of this article.
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NR 33
TC 14
Z9 15
U1 0
U2 10
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2458
J9 BMC PUBLIC HEALTH
JI BMC Public Health
PD MAY 29
PY 2013
VL 13
AR 522
DI 10.1186/1471-2458-13-522
PG 9
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA 155UK
UT WOS:000319773500001
PM 23718264
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Auclair, M
   Vigouroux, C
   Boccara, F
   Capel, E
   Vigeral, C
   Guerci, B
   Lascols, O
   Capeau, J
   Caron-Debarle, M
AF Auclair, Martine
   Vigouroux, Corinne
   Boccara, Franck
   Capel, Emilie
   Vigeral, Catherine
   Guerci, Bruno
   Lascols, Olivier
   Capeau, Jacqueline
   Caron-Debarle, Martine
TI Peroxisome Proliferator-Activated Receptor-γ Mutations Responsible for
   Lipodystrophy With Severe Hypertension Activate the Cellular
   Renin-Angiotensin System
SO ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
LA English
DT Article
DE angiotensin; hypertension; lipodystrophy; mutation; peroxisome
   proliferator-activated receptor-gamma
ID SMOOTH-MUSCLE-CELLS; DOMINANT-NEGATIVE MUTATIONS; II TYPE-1 RECEPTOR;
   PPAR-GAMMA; INSULIN-RESISTANCE; BLOOD-PRESSURE; VASCULAR DYSFUNCTION;
   METABOLIC SYNDROME; GENE-EXPRESSION; INTERFERENCE
AB Objective-Inactivating peroxisome proliferator-activated receptor-gamma (PPAR gamma) mutations lead to a syndrome of familial partial lipodystrophy (FPLD3) associated with early-onset severe hypertension. PPAR gamma can repress the vascular reninangiotensin system (RAS) and angiotensin II receptor 1 expression. We evaluated the relationships between PPAR gamma inactivation and cellular RAS using FPLD3 patients' cells and human vascular smooth muscle cells expressing mutant or wild-type PPAR gamma.
   Approach and Results-We identified 2 novel PPARG mutations, R165T and L339X, located in the DNA and ligand-binding domains of PPAR., respectively in 4 patients from 2 FPLD3 families. In cultured skin fibroblasts and peripheral blood mononuclear cells from the 4 patients and healthy controls, we compared markers of RAS activation, oxidative stress, and inflammation, and tested the effect of modulators of PPAR gamma and angiotensin II receptor 1. We studied the impact of the 2 mutations on the transcriptional activity of PPAR gamma and on the vascular RAS in transfected human vascular smooth muscle cells. Systemic RAS was not altered in patients. However, RAS markers were overexpressed in patients' fibroblasts and peripheral blood mononuclear cells, as in vascular cells expressing mutant PPAR gamma. Angiotensin II-mediated mitogen-activated protein kinase activity increased in patients' fibroblasts, consistent with RAS constitutive activation. Patients' cells also displayed oxidative stress and inflammation. PPAR gamma activation and angiotensin II receptor 1 mRNA silencing reversed RAS overactivation, oxidative stress, and inflammation, arguing for a role of angiotensin II receptor 1 in these processes.
   Conclusions-Two novel FPLD3-linked PPARG mutations are associated with a defective transrepression of cellular RAS leading to cellular dysfunction, which might contribute to the specific FPLD3-linked severe hypertension. (Arterioscler Thromb Vasc Biol. 2013; 33: 829-838.)
C1 [Auclair, Martine; Vigouroux, Corinne; Boccara, Franck; Capel, Emilie; Lascols, Olivier; Capeau, Jacqueline; Caron-Debarle, Martine] Ctr Rech St Antoine, INSERM, UMRS938, Paris, France.
   [Auclair, Martine; Vigouroux, Corinne; Boccara, Franck; Capel, Emilie; Lascols, Olivier; Capeau, Jacqueline; Caron-Debarle, Martine] Univ Paris 06, Paris, France.
   [Auclair, Martine; Vigouroux, Corinne; Boccara, Franck; Capel, Emilie; Lascols, Olivier; Capeau, Jacqueline; Caron-Debarle, Martine] Inst Cardiometab & Nutr, ICAN, Paris, France.
   [Vigouroux, Corinne; Capeau, Jacqueline] Hop Tenon, AP HP, Serv Biochim & Hormonol, F-75970 Paris, France.
   [Boccara, Franck] Hop St Antoine, AP HP, Serv Cardiol, F-75571 Paris, France.
   [Vigeral, Catherine] Hop Hotel Dieu, AP HP, Serv Diabetol & Malad Endocriniennes, F-75181 Paris, France.
   [Guerci, Bruno] CHU Nancy, Hop Jeanne dArc, Serv Diabetol Endocrinol & Nutr, Toul, France.
   [Lascols, Olivier] Hop St Antoine, AP HP, Lab Commun Biol & Genet Mol, F-75571 Paris, France.
C3 Institut National de la Sante et de la Recherche Medicale (Inserm);
   Sorbonne Universite; Sorbonne Universite; Sorbonne Universite; Institut
   National de la Sante et de la Recherche Medicale (Inserm); Assistance
   Publique Hopitaux Paris (APHP); Sorbonne Universite; Hopital
   Universitaire Tenon - APHP; Assistance Publique Hopitaux Paris (APHP);
   Sorbonne Universite; Hopital Universitaire Saint-Antoine - APHP;
   Assistance Publique Hopitaux Paris (APHP); Universite Paris Cite;
   Hopital Universitaire Hotel-Dieu - APHP; CHU de Nancy; Assistance
   Publique Hopitaux Paris (APHP); Sorbonne Universite; Hopital
   Universitaire Saint-Antoine - APHP
RP Caron-Debarle, M (corresponding author), Univ Paris 06, INSERM, UMR S938, 27 Rue Chaligny, F-75012 Paris, France.
EM martine.debarle@inserm.fr
OI Capel, Emilie/0000-0001-8396-2843; Auclair, Martine/0000-0003-3600-1999
FU Institut de la Sante et de la Recherche Medicale (INSERM); Universite
   Pierre et Marie Curie (UPMC)
FX This work has been granted by Institut de la Sante et de la Recherche
   Medicale (INSERM) and Universite Pierre et Marie Curie (UPMC).
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NR 54
TC 51
Z9 57
U1 0
U2 9
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1079-5642
EI 1524-4636
J9 ARTERIOSCL THROM VAS
JI Arterioscler. Thromb. Vasc. Biol.
PD APR
PY 2013
VL 33
IS 4
BP 829
EP U449
DI 10.1161/ATVBAHA.112.300962
PG 13
WC Hematology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Hematology; Cardiovascular System & Cardiology
GA 105ZE
UT WOS:000316110400025
PM 23393388
OA Bronze
DA 2025-06-11
ER

PT J
AU Mijevic, C
   Nikolic, M
   Nikolic-Kokic, A
   Jones, DR
   Niketic, V
   Lecic-Tosevski, D
   Spasic, MB
AF Mijevic, Cedo
   Nikolic, Milan
   Nikolic-Kokic, Aleksandra
   Jones, David R.
   Niketic, Vesna
   Lecic-Tosevski, Dusica
   Spasic, Mihajlo B.
TI Lipid status, anti-oxidant enzyme defence and haemoglobin content in the
   blood of long-term clozapine-treated schizophrenic patients
SO PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
LA English
DT Review
DE Anti-oxidant enzymes; Clozapine; Oxidative stress; Red blood cells;
   Schizophrenia
ID GLUTATHIONE-PEROXIDASE; SUPEROXIDE-DISMUTASE; OXIDATIVE STRESS;
   DIFFERENT FORMS; HALOPERIDOL; METABOLISM; SYSTEM; ERYTHROCYTES;
   ELEVATION; PLASMA
AB Objective: Despite clozapine's unique effectiveness in patients with schizophrenia, a number of adverse effects have been recognised including abnormalities in lipid and glucose metabolisms. A high clozapine level in red blood cells (RBCs) and disturbed anti-oxidant enzyme activities in blood from schizophrenic patients prompted us to investigate lipid status and anti-oxidant enzyme defence in the blood of chronic schizophrenic patients on long-term clozapine therapy.
   Methods: Plasma lipids, RBC anti-oxidant enzyme activities and haemoglobin (Hb) content were measured using established procedures in a group of eighteen chronically-medicated (average 630 days of therapy) schizophrenic patients receiving clozapine (average dose of 295 mg/day) and data were compared with those from a group of eighteen well-matched normal controls.
   Results: Significantly higher levels of plasma triglycerides (by 47%, p<0.01) and total cholesterol and phospholipids (by 8% and 11%, respectively p<0.05) in patients were found. CuZn-superoxide dismutase (SOD1) activity was markedly higher (by 35%, p<0.001) while selenium-dependent glutathione peroxidase (GSH-Px1) activity was markedly lower (by 41%, p<0.001) in patients. In addition, metHb and HbA1c levels in patients were significantly higher (by 58% and 25%. respectively p<0.001). SOD1 activity was negatively correlated (p<0.001) to GSH-Px1 activity in patients.
   Conclusions:The findings support the view that ongoing oxidative stress may be a mechanism by which clozapine induces some adverse effects that increase the risk of diabetes and metabolic syndrome. If valid, this would indicate that in parallel with long-term clozapine treatment, schizophrenic patients could be encouraged to make some lifestyle changes to limit the detrimental effects of the medication. (C) 2009 Elsevier Inc. All rights reserved.
C1 [Nikolic, Milan; Jones, David R.; Niketic, Vesna] Univ Belgrade, Dept Biochem, Fac Chem, Belgrade 11000, Serbia.
   [Mijevic, Cedo; Lecic-Tosevski, Dusica] Inst Mental Hlth, Belgrade, Serbia.
   [Nikolic-Kokic, Aleksandra; Spasic, Mihajlo B.] Univ Belgrade, Inst Biol Res Sinisa Stankovic, Dept Physiol, Belgrade 11000, Serbia.
C3 University of Belgrade; University of Belgrade
RP Nikolic, M (corresponding author), Univ Belgrade, Dept Biochem, Fac Chem, Studentski Trg 12-16, Belgrade 11000, Serbia.
EM mnikolic@chem.bg.ac.rs
RI Spasic, Mihajlo/AAE-9381-2020; Nikolic-Kokic, Aleksandra/AAD-5591-2022;
   Nikolic, Milan/P-6923-2016
OI Spasic, Mihajlo/0000-0001-9046-0139; Nikolic-Kokic,
   Aleksandra/0000-0002-1116-2035; Nikolic, Milan/0000-0003-0932-889X
FU Ministry of Science and Technological Development of the Republic of
   Serbia [142017, 143034]
FX This work was supported by the Ministry of Science and Technological
   Development of the Republic of Serbia (projects 142017 and 143034).
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NR 45
TC 32
Z9 34
U1 0
U2 6
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0278-5846
EI 1878-4216
J9 PROG NEURO-PSYCHOPH
JI Prog. Neuro-Psychopharmacol. Biol. Psychiatry
PD MAR 17
PY 2010
VL 34
IS 2
BP 303
EP 307
DI 10.1016/j.pnpbp.2009.11.024
PG 5
WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA 571XU
UT WOS:000275790500008
PM 19962416
DA 2025-06-11
ER

PT J
AU Anuradha, R
   Srinivas, M
   Satyavani, M
   Suresh, K
   Muralidhar, MN
   Rao, KR
AF Anuradha, Rachakatla
   Srinivas, M.
   Satyavani, M.
   Suresh, K.
   Muralidhar, M. N.
   Rao, Kalashikam Rajender
TI Preconceptional paternal caloric restriction of high-fat diet-induced
   obesity in Wistar rats dysregulates the metabolism of their offspring
   via AMPK/SIRT1 pathway
SO LIPIDS IN HEALTH AND DISEASE
LA English
DT Article
DE Paternal caloric restriction; Metabolic disorders; Male fertility; SIRT1
   and AMPK.
ID SIRT1; EXPRESSION; PARAMETERS; DISEASE; PROTEIN; ALTERS; BETA
AB Background Obesity is a metabolic syndrome where allelic and environmental variations together determine the susceptibility of an individual to the disease. Caloric restriction (CR) is a nutritional dietary strategy recognized to be beneficial as a weight loss regime in obese individuals. Preconceptional parental CR is proven to have detrimental effects on the health and development of their offspring. As yet studies on maternal CR effect on their offspring are well established but paternal CR studies are not progressing. In current study, the impact of different paternal CR regimes in diet-induced obese male Wistar rats (WNIN), on their offspring concerning metabolic syndrome are addressed.Methods High-fat diet-induced obese male Wistar rats were subjected to caloric restriction of 50% (HFCR-I) and 40% (HFCR-II) and then they were mated with normal females. The male parent's reproductive function was assessed by sperm parameters and their DNMT's mRNA expression levels were also examined. The offspring's metabolic function was assessed by physiological, biochemical and molecular parameters.Results The HFCR-I male parents have shown reduced body weights, compromised male fertility and reduced DNA methylation activity. Further, the HFCR-I offspring showed attenuation of the AMPK/SIRT1 pathway, which is associated with the progression of proinflammatory status and oxidative stress. In line, the HFCR-I offspring also developed altered glucose and lipid homeostasis by exhibiting impaired glucose tolerance & insulin sensitivity, dyslipidemia and steatosis. However, these effects were largely mitigated in HFCR-II offspring. Regarding the obesogenic effects, female offspring exhibited greater susceptibility than male offspring, suggesting that females are more prone to the influences of the paternal diet.Conclusion The findings highlight that HFCR-I resulted in paternal undernutrition, impacting the health of offspring, whereas HFCR-II largely restored the effects of a high-fat diet on their offspring. As a result, moderate caloric restriction has emerged as an effective weight loss strategy with minimal implications on future generations. This underscores the shared responsibility of fathers in contributing to sperm-specific epigenetic imprints that influence the health of adult offspring.
C1 [Anuradha, Rachakatla; Srinivas, M.; Satyavani, M.; Suresh, K.; Rao, Kalashikam Rajender] ICMR Natl Inst Nutr, Anim Facil, Hyderabad 500007, Telangana, India.
   [Muralidhar, M. N.] ICMR Ctr Res Management & Control Haemoglobinopath, Chandrapur 442406, Maharashtra, India.
C3 Indian Council of Medical Research (ICMR); ICMR - National Institute of
   Nutrition (NIN); Indian Council of Medical Research (ICMR)
RP Rao, KR (corresponding author), ICMR Natl Inst Nutr, Anim Facil, Hyderabad 500007, Telangana, India.
EM rkrajender@yahoo.com
RI Suresh, K/ACR-4945-2022
FU Indian Council of Medical Research (ICMR), Ansari Nagar, New Delhi,
   India [5/4/8 - 5/2019-NCD-II]
FX Funding was provided by Indian Council of Medical Research (ICMR)
   (Project File No:5/4/8 - 5/2019-NCD-II), Ansari Nagar, New Delhi, India.
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NR 64
TC 3
Z9 3
U1 3
U2 5
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1476-511X
J9 LIPIDS HEALTH DIS
JI Lipids Health Dis.
PD JUN 8
PY 2024
VL 23
IS 1
AR 174
DI 10.1186/s12944-024-02161-6
PG 15
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA TW8A5
UT WOS:001244376100003
PM 38851752
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Rodríguez-Mortera, R
   Caccavello, R
   Hermo, R
   Garay-Sevilla, ME
   Gugliucci, A
AF Rodriguez-Mortera, Reyna
   Caccavello, Russell
   Hermo, Ricardo
   Garay-Sevilla, Maria Eugenia
   Gugliucci, Alejandro
TI Higher Hepcidin Levels in Adolescents with Obesity Are Associated with
   Metabolic Syndrome Dyslipidemia and Visceral Fat
SO ANTIOXIDANTS
LA English
DT Article
DE hepcidin; ferritin; dyslipidemia; obesity; metabolic syndrome;
   atherosclerosis
ID BODY-MASS INDEX; IRON STATUS; DISORDERS; CHILDREN
AB Tightly regulated iron metabolism prevents oxidative stress. Hepcidin is a hormone that regulates iron flow in plasma; its production is induced by an iron overload and by inflammation. It inhibits iron entry into the circulation by blocking dietary absorption in the duodenum, the release of recycled iron from macrophages and the exit of stored iron from hepatocytes. Varied signals responding to iron stores, erythropoietic activity and host defense converge to regulate hepcidin production and thereby affect iron homeostasis. Although it is known that hepcidin increases when interleukin 6 (IL-6) increases, the relationship between hepcidin, dyslipidemia, insulin resistance (IR) and visceral adiposity index (VAI) in adolescents with obesity is unclear. In this cross-sectional study of 29 obese adolescents and 30 control subjects, we explored the difference of hepcidin, iron metabolism markers and IL-6 between obese and non-obese adolescents, and identified associations with inflammation, atherogenic dyslipidemia and IR. As compared to lean controls, obese participants showed 67% higher hepcidin: 14,070.8 +/- 7213.5 vs. 8419.1 +/- 4826.1 pg/mL(C); 70% higher ferritin: 94.4 +/- 82.4 vs. 55.1 +/- 39.6 pg/mL(a) and 120% higher IL-6: 2.0 (1.1-4.9) vs. 0.9 (0.5-1.3) pg/mL(d). Transferrin, soluble transferrin receptor and total body iron (as measured by sTFR/ferritin, log10 sTFR/ferritin ratio and sTFR/log ferritin ratios) were not different between the two cohorts. In the whole cohort, hepcidin correlated with VAI (r = 0.29(a)), sd-LDL (r = 0.31(b)), HOMA-IR (r = 0.29(a)) and IL-6 (r = 0.35(C)). In obese adolescents hepcidin correlated with TG (r = 0.47(b)), VLDL-C (r = 0.43(b)) and smaller LDL2 (r = 0.39(a)). Hepcidin elevation in adolescents with obesity is linked more to inflammation and metabolic alterations than to iron metabolism since the other markers of iron metabolism were not different between groups, except for ferritin. Studies addressing the long-term effects of higher hepcidin levels and their impact on subclinical anemia and iron status are warranted. (a) p < 0.05; (b) p < 0.01, (C) p < 0.001 (d) p < 0.0001.
C1 [Rodriguez-Mortera, Reyna; Garay-Sevilla, Maria Eugenia] Univ Guanajuato, Dept Med Sci, Leon 37320, Mexico.
   [Rodriguez-Mortera, Reyna; Caccavello, Russell; Hermo, Ricardo; Gugliucci, Alejandro] Touro Univ Calif, Coll Osteopath Med, Dept Res, Glycat Oxidat & Dis Lab, Vallejo, CA 94592 USA.
C3 Universidad de Guanajuato; Touro University California
RP Gugliucci, A (corresponding author), Touro Univ Calif, Coll Osteopath Med, Dept Res, Glycat Oxidat & Dis Lab, Vallejo, CA 94592 USA.
EM ln.reynarm@gmail.com; russell.caccavello@tu.edu; rhermo1055@gmail.com;
   marugaray_@hotmail.com; alejandro.gugliucci@tu.edu
RI Rodríguez-Mortera, Reyna/H-1727-2011
OI Garay-Sevilla, Ma. Eugenia/0000-0002-6758-3197
FU Touro University-California [069]; Grant DAIP University of Guanajuato
   [011/2015]
FX Touro University-California (069) and Grant DAIP University of
   Guanajuato (Project 011/2015).
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NR 24
TC 16
Z9 17
U1 1
U2 8
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD MAY
PY 2021
VL 10
IS 5
AR 751
DI 10.3390/antiox10050751
PG 9
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA SG3KF
UT WOS:000653340100001
PM 34065056
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Sardu, C
   Marfella, R
   Santamaria, M
   Papini, S
   Parisi, Q
   Sacra, C
   Colaprete, D
   Paolisso, G
   Rizzo, MR
   Barbieri, M
AF Sardu, Celestino
   Marfella, Raffaele
   Santamaria, Matteo
   Papini, Stefano
   Parisi, Quintino
   Sacra, Cosimo
   Colaprete, Daniele
   Paolisso, Giuseppe
   Rizzo, Maria R.
   Barbieri, Michelangela
TI Stretch, Injury and Inflammation Markers Evaluation to Predict Clinical
   Outcomes After Implantable Cardioverter Defibrillator Therapy in Heart
   Failure Patients With Metabolic Syndrome
SO FRONTIERS IN PHYSIOLOGY
LA English
DT Article
DE ST2 protein; heart failure; internal cardioverter defibrillator; ICDs'
   shocks; hospitalization
ID CARDIAC RESYNCHRONIZATION THERAPY; SOLUBLE ST2; MYOCARDIAL-INFARCTION;
   NATRIURETIC PEPTIDES; EUROPEAN-SOCIETY; TASK-FORCE; DEATH; ASSOCIATION;
   MANAGEMENT; COLLEGE
AB Background: Internal cardioverter defibrillator (ICD) therapy reduced all-cause mortality. Conversely, few studies reported that ICDs' shocks may reduce survival. Recently authors suggested that, multiple inflammatory and molecular pathways were related to worse prognosis in metabolic syndrome (MS) patients treated by ICDs. Therefore, it may be relevant to find new biomarkers to predict ICDs' shock and worse prognosis in treated patients.
   Methods: In 99MS vs. 107 no MS patients treated by ICD for primary prevention, we evaluated all-cause mortality, cardiac deaths, hospitalization for heart failure, appropriate and inappropriate therapy, and survival after appropriate ICD therapy.
   Results: MS vs. no MS patients had higher levels of failing heart stress biomarkers. The highest values of ST2 were related to worse prognosis. Patients who had better survival after appropriate ICD therapy were those associated with lowest ST2 values. At multivariate Cox regression analysis, C reactive protein (CRP) (0.110 [0.027-0.446], p-value 0.002), troponine I (TnI) protein (0.010 [0.001-0.051], p-value 0.010), and B type natriuretic peptide (BNP) (1.151 [1.010-1.510], p-value 0.001), predicted all cause of deaths. BNP predicted cardiac deaths (1.010 [1.001-1.206], p-value 0.033). MS, and BNP predicted hospitalization for heart failure events (2.902 [1.345-4.795], p-value 0.001; 1.005 [1.000-1.016], p-value 0.007). ST2 predicted appropriate therapy (1.012 [1.007-1.260], p-value 0.001), as BNP (1.005 [1.001-1.160], p-value 0.028), LVEF (1.902 [1.857-1.950], p-value 0.001), and CRP (1.833 [1.878-1.993], p-value 0.028). ST2, and BNP predicted survival after ICD appropriate therapy (4.297 [1.985-9.302], p-value 0.001; 1.210 [1.072-1.685], p-value 0.024).
   Conclusions: ST2 values may differentiate MS patients with a higher risk of ICDs' therapy, and worse prognosis. Therefore, ST2 protein may be used as valid monitoring biomarker, and as a predictive biomarker in failing heart ICDs' patients affected by MS.
C1 [Sardu, Celestino; Marfella, Raffaele; Paolisso, Giuseppe; Rizzo, Maria R.; Barbieri, Michelangela] Univ Campania Luigi Vanvitelli, Dept Med Surg Neurol Metab & Aging Sci, Naples, Italy.
   [Santamaria, Matteo; Papini, Stefano; Parisi, Quintino; Sacra, Cosimo; Colaprete, Daniele] John Paul II Res & Care Fdn, Dept Cardiovasc & Arrhythmias, Campobasso, Italy.
C3 Universita della Campania Vanvitelli
RP Sardu, C (corresponding author), Univ Campania Luigi Vanvitelli, Dept Med Surg Neurol Metab & Aging Sci, Naples, Italy.
EM drsarducele@gmail.com
RI Rizzo, Maria Rosaria/AHH-3649-2022; paolisso, giuseppe/AAP-8516-2020;
   Santamaria, Matteo/U-4066-2019; Sacra, Cosimo/AAS-9085-2020; Sardu,
   Celestino/AAA-7451-2019; Marfella, Raffaele/AAH-2595-2019; Barbieri,
   Michelangela/K-2192-2016
OI Rizzo, Maria Rosaria/0000-0002-1023-4260; Santamaria,
   Matteo/0000-0003-1000-0592; Papini, Stefano/0000-0001-5158-5385; Sardu,
   Celestino/0000-0001-5099-3790; Sacra, Cosimo/0000-0003-4684-2521;
   Barbieri, Michelangela/0000-0002-9223-5792
CR Alpert JS, 2000, J AM COLL CARDIOL, V36, P959, DOI 10.1016/S0735-1097(00)00804-4
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NR 27
TC 42
Z9 43
U1 0
U2 5
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1664-042X
J9 FRONT PHYSIOL
JI Front. Physiol.
PD JUN 26
PY 2018
VL 9
AR 758
DI 10.3389/fphys.2018.00758
PG 15
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA GK6SJ
UT WOS:000436320000001
PM 29997521
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Scassellati, C
   Bonvicini, C
   Benussi, L
   Ghidoni, R
   Squitti, R
AF Scassellati, Catia
   Bonvicini, Cristian
   Benussi, Luisa
   Ghidoni, Roberta
   Squitti, Rosanna
TI Neurodevelopmental disorders: Metallomics studies for the identification
   of potential biomarkers associated to diagnosis and treatment
SO JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
LA English
DT Review
DE Diagnosis; Treatment; Neurodevelopmental disorders; Biomarkers;
   Metallomics; Biometals; Metallomes
ID ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; ESSENTIAL TRACE-METALS; SERUM
   COPPER; SCHIZOPHRENIC-PATIENTS; CSF COPPER; ZINC; ELEMENTS; IRON;
   MANGANESE; SELENIUM
AB Background: Diagnosis and treatment of complex diseases such as Neurodevelopmental Disorders (NDDs) can be resolved through the identification of biomarkers. Metallomics (research on biometals) and metallomes (metalloproteins/metalloenzymes/chaperones) along with genomics, proteomics and metabolomics, can contribute to accelerate and improve this process.
   Aim: This review focused on four NDDs pathologies (Schizophrenia, SZ; Attention Deficit Hyperactivity Disorder, ADHD; Autism, ADS; Epilepsy), and we reported, for the first time, different studies on the role played by the principal six essential trace elements (Cobalt, Co; Copper, Cu; Iron, Fe; Manganese, Mn; Selenium, Se; Zinc, Zn) that can influence diagnosis/treatment.
   Results: in light of the literature presented, based on meta-analyses, we suggest that Zn (glutamatergic neurotransmission, inflammation, neurodegeneration, autoimmunity alterations), could be a potential diagnostic biomarker associated to SZ. Moreover, considering the single association studies going in the same direction, increased Cu (catecholamine alterations, glucose intolerance, altered lipid metabolism/oxidative stress) and lower Fe (dopaminergic dysfunctions) levels were associated with a specific negative symptomatology. Lower Mn (lipid metabolism/oxidative stress alterations), and lower Se (metabolic syndrome) were linked to SZ. From the meta-analyses in ADHD, it is evidenced that Fe (and ferritin in particular), Mn, and Zn (oxidative stress dysfunctions) could be potential diagnostic biomarkers, mainly associated to severe hyperactive or inattentive symptoms; as well as Cu, Fe, Zn in ADS and Zn in Epilepsy. Fe, Zn and Mn levels seem to be influenced by antipsychotics treatment in SZ; Mn and Zn by methylphenidate treatment in ADHD; Cu and Zn by antiepileptic drugs in Epilepsy.
   Conclusions: Although there is controversy and further studies are needed, this work summarizes the state of art of the literature on this topic. We claim to avoid underreporting the impact of essential trace elements in paving the way for biomarkers research for NDDs.
C1 [Scassellati, Catia; Bonvicini, Cristian; Benussi, Luisa; Ghidoni, Roberta; Squitti, Rosanna] IRCCS Ist Ctr San Giovanni Dio Fatebenefratelli, Mol Markers Lab, Brescia, Italy.
C3 IRCCS Fatebenefratelli
RP Scassellati, C (corresponding author), IRCCS Ist Ctr San Giovanni Dio Fatebenefratelli, Via Pilastroni 4, I-25027 Brescia, Italy.
EM c.scassellati@fatebenefratelli.eu
RI Bonvicini, Cristian/G-4427-2011; Benussi, Luisa/K-4409-2016; Squitti,
   Rosanna/KSL-9262-2024; Ghidoni, Roberta/K-4507-2016; Scassellati,
   Catia/J-7710-2016
OI Bonvicini, Cristian/0000-0003-1577-2823; Benussi,
   Luisa/0000-0003-2836-8141; Squitti, Rosanna/0000-0002-5624-1140;
   Ghidoni, Roberta/0000-0002-7691-1957; Scassellati,
   Catia/0000-0003-2077-0830
FU Italian Ministry of Health
FX This research was supported by grants from the Italian Ministry of
   Health (Ricerca Corrente).
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NR 76
TC 35
Z9 37
U1 2
U2 53
PU ELSEVIER GMBH
PI MUNICH
PA HACKERBRUCKE 6, 80335 MUNICH, GERMANY
SN 0946-672X
EI 1878-3252
J9 J TRACE ELEM MED BIO
JI J. Trace Elem. Med. Biol.
PD JUL
PY 2020
VL 60
AR 126499
DI 10.1016/j.jtemb.2020.126499
PG 7
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA LB1SC
UT WOS:000524414400017
PM 32203724
OA hybrid
DA 2025-06-11
ER

PT J
AU Morimoto, H
   Sakata, K
   Oishi, M
   Tanaka, K
   Nakada, S
   Nogawa, K
   Suwazono, Y
AF Morimoto, H.
   Sakata, K.
   Oishi, M.
   Tanaka, K.
   Nakada, S.
   Nogawa, K.
   Suwazono, Y.
TI Effect of high-sensitivity C-reactive protein on the development of
   diabetes as demonstrated by pooled logistic-regression analysis of
   annual health-screening information from male Japanese workers
SO DIABETES & METABOLISM
LA English
DT Article
DE High-sensitivity C-reactive protein; Diabetes mellitus; Male;
   Job-related stress; Predictive value; Incidence; Longitudinal study;
   Japan; HbA(1c); Body mass index; Cohort study
ID SCOTLAND CORONARY PREVENTION; INFLAMMATORY MARKERS; SHIFT WORK;
   ALCOHOL-CONSUMPTION; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   RISK-FACTOR; MELLITUS; PREDICTOR; COHORT
AB Aim. The aim of this study was to determine the relationship between the development of diabetes mellitus and high-sensitivity C-reactive protein (HsCRP) adjusted for various potential confounders.
   Methods. This 5-year prospective cohort study was conducted at a Japanese steel factory and involved male workers who had received annual health screenings between 2005 and 2010. The 7392 male participants were aged 19-75 years. The study endpoint, the development of diabetes mellitus, was defined as HbA(1c) greater or equal to 6.5% or the use of antidiabetic medication. The association between variables was investigated using pooled logistic regression adjusted for various covariates such as age, baseline body mass index (BMI) and increase in BMI from baseline, blood biochemistry, job schedule and job-related stress.
   Results. The incidence rate of diabetes development per 1000 person-years was 13.9. Multivariate analysis showed a significant relationship between the development of diabetes and elevated levels of baseline HsCRP and increases in levels from baseline. The Odds ratios for a 2.9-fold (+/- 1 geometric standard deviation) increase in baseline HsCRP and increase in HsCRP level from baseline were 1.18 [95% confidence interval (CI): 1.03-1.34; P=0.018] and 1.21 (95% CI: 1.03-1.41; P=0.018), respectively.
   Conclusion. The present study has indicated that HsCRP is an independent predictor for the development of diabetes in men, together with various confounders such as BMI, type of job schedule and job-related stress. (C) 2012 Elsevier Masson SAS. All rights reserved.
C1 [Morimoto, H.; Sakata, K.; Oishi, M.; Tanaka, K.; Nogawa, K.; Suwazono, Y.] Chiba Univ, Dept Occupat & Environm Med, Grad Sch Med, Chuo Ku, Chiba 2608670, Japan.
   [Nakada, S.] Chiba Univ, Safety & Hlth Org, Chiba 2608670, Japan.
   [Suwazono, Y.] Chiba Univ, Ctr Prevent Med Sci, Chiba 2608670, Japan.
C3 Chiba University; Chiba University; Chiba University
RP Suwazono, Y (corresponding author), Chiba Univ, Dept Occupat & Environm Med, Grad Sch Med, Chuo Ku, Chiba 2608670, Japan.
EM suwa@faculty.chiba-u.jp
FU Japan Society for the Promotion of Science [17590508]; Kashiwado
   Memorial Foundation for Medical Research; Grants-in-Aid for Scientific
   Research [17590508] Funding Source: KAKEN
FX This study was supported by a grant from the Japan Society for the
   Promotion of Science [Grants-in-Aid for Scientific Research, (C) No.
   17590508] and a grant from the Kashiwado Memorial Foundation for Medical
   Research.
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NR 41
TC 14
Z9 14
U1 0
U2 5
PU MASSON EDITEUR
PI MOULINEAUX CEDEX 9
PA 21 STREET CAMILLE DESMOULINS, ISSY, 92789 MOULINEAUX CEDEX 9, FRANCE
SN 1262-3636
EI 1878-1780
J9 DIABETES METAB
JI Diabetes Metab.
PD FEB
PY 2013
VL 39
IS 1
BP 27
EP 33
DI 10.1016/j.diabet.2012.03.004
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 119JF
UT WOS:000317092900005
PM 22559931
DA 2025-06-11
ER

PT J
AU Helmersson, J
   Vessby, B
   Larsson, A
   Basu, S
AF Helmersson, J
   Vessby, B
   Larsson, A
   Basu, S
TI Association of type 2 diabetes with cyclooxygenase-mediated inflammation
   and oxidative stress in an elderly population
SO CIRCULATION
LA English
DT Article
DE diabetes mellitus; inflammation; prostaglandins; free radicals
ID C-REACTIVE PROTEIN; 8-ISO-PROSTAGLANDIN F2-ALPHA; LIPID-PEROXIDATION;
   METABOLIC SYNDROME; VITAMIN-E; IN-VIVO; INTERLEUKIN-6; DISEASE; INJURY;
   INDEX
AB Background - Involvement of cyclooxygenase ( COX)- mediated inflammation in type 2 diabetes has not been studied, and the association between cytokine-mediated inflammation and diabetes is not fully clarified.
   Methods and Results -15-Keto-dihydro-prostaglandin F-2alpha (a metabolite of prostaglandin F-2alpha and an indicator of COX-mediated inflammation), high-sensitivity C-reactive protein (CRP), serum amyloid protein A (SAA), 8-iso-PGF(2alpha) ( a nonenzymatic, free radical product of arachidonic acid and an indicator of oxidative stress), and alpha-tocopherol were measured in a population-based sample of 77-year-old men ( n = 765), in which 112 men had type 2 diabetes. The inflammatory indicators were increased in men with diabetes ( urinary 15-keto-dihydro-PGF(2alpha), P < 0.001, CRP and SAA, P < 0.05). However, when adjusted for body mass index, waist circumference, or fasting insulin, no association was found between diabetes and CRP or SAA. The oxidative stress indicator 8-iso-PGF(2alpha) in urine was increased (P < 0.01) in men with diabetes. Patients who were newly diagnosed with diabetes (<7 years since diagnosis) had increased urinary 15-keto-dihydro-PGF(2alpha) and decreased alpha-tocopherol, but 8-iso-PGF(2alpha) was unaltered.
   Conclusions - This is the first study to show that type 2 diabetes in elderly men is related to COX-mediated inflammation, reflected by enhanced prostaglandin formation. The high levels of cytokine-mediated acute-phase proteins observed in men with diabetes appear to be related to obesity and increased fasting insulin. The results further suggest that the appearance of chronic inflammation is an early process in the pathogenesis of diabetes, whereas oxidative injury may be a later process, possibly related to inflammation.
C1 Uppsala Univ, Fac Med, Sect Geriatr, SE-75125 Uppsala, Sweden.
   Uppsala Univ, Fac Med, Sect Clin Nutr Res, SE-75125 Uppsala, Sweden.
   Uppsala Univ, Fac Med, Sect Clin Chem, SE-75125 Uppsala, Sweden.
C3 Uppsala University; Uppsala University; Uppsala University
RP Uppsala Univ, Fac Med, Sect Geriatr, Box 609, SE-75125 Uppsala, Sweden.
EM Samar.Basu@pubcare.uu.se
CR [Anonymous], PUBL WHO
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NR 33
TC 187
Z9 212
U1 0
U2 9
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0009-7322
EI 1524-4539
J9 CIRCULATION
JI Circulation
PD APR 13
PY 2004
VL 109
IS 14
BP 1729
EP 1734
DI 10.1161/01.CIR.0000124718.99562.91
PG 6
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 811VN
UT WOS:000220799500009
PM 15037525
OA Bronze
DA 2025-06-11
ER

PT J
AU Maruani, J
   Anderson, G
   Etain, B
   Lejoyeux, M
   Bellivier, F
   Geoffroy, PA
AF Maruani, Julia
   Anderson, George
   Etain, Bruno
   Lejoyeux, Michel
   Bellivier, Frank
   Geoffroy, Pierre A.
TI The neurobiology of adaptation to seasons: Relevance and correlations in
   bipolar disorders
SO CHRONOBIOLOGY INTERNATIONAL
LA English
DT Article
DE Chronobiology; photoperiodism; light; melatonin; biological clock;
   circadian rhythm; 5-HT; suprachiasmatic nuclei (SCN)
ID SEROTONIN TRANSPORTER BINDING; N-ACETYLTRANSFERASE ACTIVITY;
   CARDIOVASCULAR RISK-FACTORS; ARYL-HYDROCARBON RECEPTOR;
   CIRCADIAN-RHYTHMS; SUPRACHIASMATIC NUCLEUS; MELATONIN SYNTHESIS;
   NITROSATIVE STRESS; METABOLIC SYNDROME; GENE-EXPRESSION
AB Bipolar disorders (BDs) are severe and common psychiatric disorders. BD pathogenesis, clinical manifestations and relapses are associated with numerous circadian rhythm abnormalities. In addition, infradian fluctuations of mood, social activity, weight and sleep patterns are very frequent in BD. Disease course with a seasonal pattern (SP) occurs in approximately 25% of depressive and 15% of manic episodes, which is coupled to a more severe disease symptomatology. The pathophysiological mechanisms of seasonal effects in BD await clarification, with likely important clinical consequences. This review aims at synthesizing available data regarding the underlying pathophysiological mechanisms of seasonality in BD patients, with implications for future research directions in the study of seasonality in BD. Three factors are suggested to play significant roles in BD with SP, namely the suprachiasmatic nuclei, as well as the melatonergic and photoperiodism systems. It is proposed that BD with SP may be considered as a complex disorder resulting from the interaction of clock gene vulnerabilities and biological clock neuroplasticity, with environmental factors, such as the response to light. Light seems to play a key role in BD with SP, mainly due to two seasonal signaling pathways: a light to cortex serotonin transporter pathway, as well as a pathway connecting light to melatonin synthesis. This provides a theoretical framework for BD with SP, including for future research and clinical management. The review proposes that future research should explore markers of seasonality in BD, such as plasma melatonin, sleep-wake rhythms (with actigraphy) and genetic or epigenetic variants within the melatonin synthesis pathway. The role of light in driving BD with SP is an active area of research. Seasonality may also be intimately linked to wider aspects of BD, including via interactions with the gut microbiome, the gut-liver axis, cholesterol regulation, aspects of metabolic syndrome, vitamin D, decreased longevity, suicide risk and medication treatment targets. Further research on the role of seasonality in BD is likely to clarify the etiology, course and treatment of BD more widely.
C1 [Maruani, Julia; Etain, Bruno; Bellivier, Frank; Geoffroy, Pierre A.] INSERM, U1144, Paris, France.
   [Maruani, Julia; Etain, Bruno; Bellivier, Frank; Geoffroy, Pierre A.] Univ Paris 05, UMR S 1144, Paris, France.
   [Maruani, Julia; Etain, Bruno; Lejoyeux, Michel; Bellivier, Frank; Geoffroy, Pierre A.] Univ Paris Diderot, Sorbonne Paris Cite, UMR S 1144, Paris, France.
   [Maruani, Julia; Etain, Bruno; Bellivier, Frank; Geoffroy, Pierre A.] GH St Louis Lariboisiere F Widal, AP HP, Pole Psychiat & Med Addictol, Paris, France.
   [Maruani, Julia; Etain, Bruno; Bellivier, Frank; Geoffroy, Pierre A.] Fondat FondaMental, Creteil, France.
   [Anderson, George] CRC Scotland & London, London, England.
   [Lejoyeux, Michel] Paris Hosp Grp Psychiat & Neurosci, Dept Epidemiol, Paris, France.
   [Lejoyeux, Michel] Univ Hosp Bichat Claude Bernard, AP HP, Dept Psychiat & Addict Med, Paris, France.
   [Lejoyeux, Michel] Paris Diderot Univ Paris VII, Paris, France.
C3 Universite Paris Cite; Institut National de la Sante et de la Recherche
   Medicale (Inserm); Universite Paris Cite; Universite Paris Cite;
   Assistance Publique Hopitaux Paris (APHP); Universite Paris Cite;
   Hopital Universitaire Lariboisiere-Fernand-Widal - APHP; Hopital
   Universitaire Saint-Louis - APHP; Universite Paris Cite; GHU PARIS
   Psychiatrie Neurosciences; Assistance Publique Hopitaux Paris (APHP);
   Universite Paris Cite; Hopital Universitaire Bichat-Claude Bernard -
   APHP; Universite Paris Cite
RP Maruani, J; Geoffroy, PA (corresponding author), INSERM, U1144, Paris, France.; Maruani, J; Geoffroy, PA (corresponding author), Univ Paris 05, UMR S 1144, Paris, France.; Maruani, J; Geoffroy, PA (corresponding author), Univ Paris Diderot, Sorbonne Paris Cite, UMR S 1144, Paris, France.; Maruani, J; Geoffroy, PA (corresponding author), GH St Louis Lariboisiere F Widal, AP HP, Pole Psychiat & Med Addictol, Paris, France.; Maruani, J; Geoffroy, PA (corresponding author), Fondat FondaMental, Creteil, France.
EM maruanijulia@gmail.com; pierre.a.geoffroy@gmail.com
RI Etain, Bruno/L-6647-2017; Anderson, George/AEO-3626-2022; Geoffroy,
   Pierre Alexis/D-9743-2011
OI Etain, Bruno/0000-0002-5377-1488; Anderson, George/0000-0001-7243-0817;
   Geoffroy, Pierre Alexis/0000-0001-9121-209X
FU INSERM (Institut National de la Sante et de la Recherche Medicale);
   AP-HP (Assistance Publique des Hopitaux de Paris); Fondation FondaMental
   (RTRS Sante Mentale); labex Bio-PSY (Investissements d'Avenir program)
   [ANR-11-IDEX-0004-02]
FX Authors acknowledge the support provided by INSERM (Institut National de
   la Sante et de la Recherche Medicale), AP-HP (Assistance Publique des
   Hopitaux de Paris), the Fondation FondaMental (RTRS Sante Mentale), and
   the labex Bio-PSY (Investissements d'Avenir program managed by the ANR
   under reference ANR-11-IDEX-0004-02).
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NR 110
TC 46
Z9 48
U1 0
U2 7
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 0742-0528
EI 1525-6073
J9 CHRONOBIOL INT
JI Chronobiol. Int.
PY 2018
VL 35
IS 10
BP 1335
EP 1353
DI 10.1080/07420528.2018.1487975
PG 19
WC Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Life Sciences & Biomedicine - Other Topics; Physiology
GA HA7DN
UT WOS:000450441500002
PM 29939763
DA 2025-06-11
ER

PT J
AU Joubert, MBV
   Ingaramo, PI
   Collins, P
   D'Alessandro, ME
AF Joubert, Michelle Berenice Vega
   Ingaramo, Paola Ines
   Collins, Pablo
   D'Alessandro, Maria Eugenia
TI Astaxanthin improves lipotoxicity, lipid peroxidation and oxidative
   stress in kidney of sucrose-rich diet-fed rats
SO JOURNAL OF NUTRITIONAL BIOCHEMISTRY
LA English
DT Article
DE Astaxanthin; Renal damage; Lipotoxicity; Oxidative stress; Sucrose-rich
   diet; Rats.
ID ADIPOSE-TISSUE DYSFUNCTION; REDUCES BLOOD-PRESSURE; INFLAMMATORY
   CYTOKINES; INDUCED OBESITY; LIVER; MICE; DYSLIPIDEMIA; NEPHROPATHY;
   GLUTATHIONE; RODENTS
AB Metabolic Syndrome (MS) is a cluster of metabolic risk factors, characterized by abdominal obesity, dyslipidemia, hypertension, insulin resistance, among others. The purpose of the study was to evaluate the astaxanthin (AXT) effects extracted from freshwater crab ( Dilocarcinus pagei) at the Paran & aacute; Basin on lipotoxicity, lipid peroxidation and oxidative stress in the kidney of rats fed with a sucrose-rich diet (SRD). We hypothesized that daily administration of AXT prevents kidney damage by reducing lipotoxicity, lipid peroxidation, and reactive oxygen species (ROS), and by improving antioxidant enzyme defenses and crosstalk between NrF2 and NF-KB transcription factors. Male Wistar rats were fed a reference diet (RD), RD +AXT, SRD and SRD +AXT (AXT daily oral dose: [10 mg/kg body weight]) for 90 days. Systolic and diastolic blood pressure, biochemical assays in serum and urine were evaluated. Renal cortex samples were taken for histological analysis, determination of triglyceride content, ROS, thiobarbituric acid reactive substances (TBARS), catalase (CAT), glutathione peroxidase (GPx) and glutathione reductase (GR) enzyme activities and glutathione content (GSH). 4-HNE, NrF2, and NF-KB p65 expression were analyzed by immunohistochemistry. We demonstrated that daily oral supplementation of AXT to animals fed a SRD reduced systolic and diastolic blood pressure, histological renal damage, lipid accumulation, ROS and lipid peroxidation, and increased CAT and GPx activities. NrF2 protein expression in renal cortex was increased, whilst NF-KB p65 was reduced. AXT extracted from freshwater crabs ( Dilocarcinus pagei) may be promising nutritional strategy for the prevention of renal alterations present in this model. (c) 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.
C1 [Joubert, Michelle Berenice Vega; D'Alessandro, Maria Eugenia] Univ Nacl Litoral, Fac Bioquim & Ciencias Biol, Dept Ciencias Biol, Lab Estudio Enfermedades Metab relacionadas con Nu, Santa Fe, Argentina.
   [Joubert, Michelle Berenice Vega; D'Alessandro, Maria Eugenia] Consejo Nacl Invest Cient & Tecn CONICET, Santa Fe, Argentina.
   [Ingaramo, Paola Ines] Consejo Nacl Invest Cient & Tecn CONICET, Fac Bioquim & Cs Biol, Dept Fisiopatol Ambiental, Inst Salud & Ambiente Litoral ISAL, Santa Fe, Argentina.
   [Collins, Pablo] Univ Nacl Litoral, Consejo Nacl Invest Cient & Tecn CONICET, Dept Acuicultura, Inst Nacl Limnol INALI, Santa Fe, Argentina.
C3 National University of the Littoral; Consejo Nacional de Investigaciones
   Cientificas y Tecnicas (CONICET); Consejo Nacional de Investigaciones
   Cientificas y Tecnicas (CONICET); National University of the Littoral;
   Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET)
RP D'Alessandro, ME (corresponding author), Univ Nacl Litoral, Fac Bioquim & Ciencias Biol, Ciudad Univ, RA-3000 Santa Fe, Argentina.
EM medaless@fbcb.unl.edu.ar
RI Collins, Pablo/Q-7376-2017
OI Collins, Pablo/0000-0001-9611-9089; D' Alessandro, Maria
   Eugenia/0000-0001-6008-5614
FU Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET) ,
   Argentina [11220200101185CO]
FX This work was supported by Consejo Nacional de Investigaciones
   Cientificas y Tecnicas (CONICET) , Argentina [PIP 2021-2023 GI
   #11220200101185CO] .
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NR 84
TC 4
Z9 4
U1 3
U2 4
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0955-2863
EI 1873-4847
J9 J NUTR BIOCHEM
JI J. Nutr. Biochem.
PD JAN
PY 2025
VL 135
AR 109779
DI 10.1016/j.jnutbio.2024.109779
EA OCT 2024
PG 12
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA K8Q9U
UT WOS:001346499400001
PM 39374743
DA 2025-06-11
ER

PT J
AU Bautista, CJ
   Reyes-Castro, LA
   Lomas-Soria, C
   Ibáñez, CA
   Zambrano, E
AF Bautista, Claudia J.
   Reyes-Castro, Luis A.
   Lomas-Soria, Consuelo
   Ibanez, Carlos A.
   Zambrano, Elena
TI Late-in-life Exercise Ameliorates the Aging Trajectory Metabolism
   Programmed by Maternal Obesity in Rats: It is Never Too Late
SO ARCHIVES OF MEDICAL RESEARCH
LA English
DT Article
DE Maternal obesity; Exercise intervention; Aging; Metabolism; Oxidative
   stress
ID HIGH-FAT DIET; BODY-WEIGHT GAIN; OXIDATIVE STRESS; PHYSICAL-ACTIVITY;
   GENE-EXPRESSION; ONSET EXERCISE; CONSUMPTION; HIPPOCAMPAL; MECHANISMS;
   REGULATORS
AB Background. Maternal obesity (MO) has been shown to adversely affect metabolic, oxidative, reproductive, and cognitive function in offspring. However, it is unclear whether lifestyle modification can ameliorate the metabolic and organ dysfunction programmed by MO and prevent the effects of metabolic syndrome in adulthood. This study aimed to evaluate whether moderate voluntary exercise in the offspring of rats born to obese mothers can ameliorate the adverse effects of MO programming on metabolism and liver function in mid-adulthood. Methods. Offspring of control (CF1) and MOF1 mothers were fed with a control diet from weaning. Adult males and females participated in 15 min exercise sessions five days/week. Metabolic parameters were analyzed before and after the exercise intervention. Liver oxidative stress biomarkers and antioxidant enzymes were analyzed before and after the intervention. Results. Males showed that CF1 ex ran more than MOF1 ex and increased the distance covered. In contrast, females in both groups ran similar distances and remained constant but ran more distance than males. At PND 300 and 450, male and female MOF1 had higher leptin, triglycerides, insulin, and HOMA-IR levels than CF1. However, male MOF1 ex had lower triglycerides, insulin, and HOMA-IR levels than MOF1. Improvements in liver fat and antioxidant enzymes were observed in CF1 ex and MOF1 ex males and females compared to their respective CF1 and MOF1 groups. Conclusion. These findings suggest that moderate voluntary exercise, even when started in mid-adulthood, can improve metabolic outcomes and delay accelerated metabolic aging in MO-programmed rats in a sex -dependent manner. (c) 2024 Instituto Mexicano del Seguro Social (IMSS). Published by Elsevier Inc. All rights reserved.
C1 [Bautista, Claudia J.; Reyes-Castro, Luis A.; Lomas-Soria, Consuelo; Ibanez, Carlos A.; Zambrano, Elena] Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Vasco Quiroga 15,Col Belisario Dominguez,Sec XVI, Mexico City, Mexico.
   [Lomas-Soria, Consuelo] Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Biol Reprod, Consejo Nacl Human Ciencias & Tecnol, Catedras Investigador Mexico, Mexico City, Mexico.
   [Zambrano, Elena] Univ Nacl Autonoma Mexico, Fac Quim, Mexico City, Mexico.
C3 Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran -
   Mexico; Instituto Nacional de Ciencias Medicas y Nutricion Salvador
   Zubiran - Mexico; Universidad Nacional Autonoma de Mexico
RP Zambrano, E (corresponding author), Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Vasco Quiroga 15,Col Belisario Dominguez,Sec XVI, Mexico City, Mexico.
EM elena.zambranog@incmnsz.mx
RI REYES CASTRO, LUIS ANTONIO/E-9896-2019; Ibanez Chavez, Carlos
   Alberto/AAG-2398-2020
OI Ibanez Chavez, Carlos Alberto/0000-0002-3435-497X; Zambrano,
   Elena/0000-0002-0362-9117
FU Consejo Nacional de Humanidades, Ciencias y Tecnologias (CONAHCyT)
   [155166]; Newton Fund RCUK-CONACyT (Research Councils UK-Consejo
   Nacional de Ciencia y Tecnologia), Mexico [I000/726/2016
   FONCICYT/49/2016]
FX This study was supported by the Consejo Nacional de Humanidades,
   Ciencias y Tecnologias (CONAHCyT) 155166 and the Newton Fund
   RCUK-CONACyT (Research Councils UK-Consejo Nacional de Ciencia y
   Tecnologia) I000/726/2016 FONCICYT/49/2016, Mexico.
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NR 102
TC 0
Z9 0
U1 1
U2 4
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0188-4409
EI 1873-5487
J9 ARCH MED RES
JI Arch. Med. Res.
PD JUN
PY 2024
VL 55
IS 4
AR 103002
DI 10.1016/j.arcmed.2024.103002
EA MAY 2024
PG 16
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA TJ1O0
UT WOS:001240806700001
PM 38735235
DA 2025-06-11
ER

PT J
AU Jaiswal, A
   Madaan, S
   Acharya, N
   Kumar, S
   Talwar, D
   Dewani, D
AF Jaiswal, Arpita
   Madaan, Sparsh
   Acharya, Neema
   Kumar, Sunil
   Talwar, Dhruv
   Dewani, Deepika
TI Salivary Uric Acid: A Noninvasive Wonder for Clinicians?
SO CUREUS JOURNAL OF MEDICAL SCIENCE
LA English
DT Review
DE human immunodeficiency virus; hyperuricemia; cancer; saliva; uric acid
ID OXIDATIVE STRESS; SERUM; OBESITY
AB This review is a summary of the modern-day approach and recent trend in the determination of uric acid in the saliva of humans and its use in diagnosis by clinicians. Uric acid, which is the end product obtained from the breakdown of purine nucleotides, is an important biomarker associated with various conditions. Uric acid is found in various body fluids, such as serum, plasma, and urine. It can be used as an important tool for various diseases, such as gout and hyperuricemia, or conditions that are associated with increased oxidative stress. Recently, there has been an emergence of studies that have utilized uric acid concentrations measured in the saliva and studied its association with various diseases. Salivary uric acid can prove to be a noninvasive method to provide a diagnosis of serious illness. A raised uric acid level in the saliva can be associated with cancer, human immunodeficiency virus (HIV) infection, gout, and hypertension. A reduced level of salivary uric acid on the other hand can be a marker for Alzheimer's disease, progression of multiple sclerosis, and impairment of cognition.
   Online search databases, including Google Scholar, Scopus, PubMed, and Web of Science, were searched, and articles that were published before September 2021 based on salivary uric acid analysis were analyzed for this review.
   Uric acid is an essential biomarker that has antioxidant properties. Assessment of salivary uric acid levels was found to be essential in conditions such as cancer, metabolic syndrome, neurological conditions, psychiatric conditions, human immunodeficiency virus, and gout and in monitoring treatment of hyperuricemia.
   Although having importance in diagnosis and therapeutic monitoring, salivary uric acid analysis has not gained enough popularity due to limitations such as saliva collection and sample processing issues. With proper education and standardization, salivary uric acid analysis can be used as a cost-effective and noninvasive tool for getting a clue about antioxidant biomarker concentration in saliva and hence various diseases associated with oxidative stress.
C1 [Jaiswal, Arpita; Madaan, Sparsh; Acharya, Neema; Dewani, Deepika] Datta Meghe Inst Med Sci, Jawaharlal Nehru Med Coll, Dept Obstet & Gynaecol, Wardha, India.
   [Kumar, Sunil; Talwar, Dhruv] Datta Meghe Inst Med Sci, Dept Med, Jawaharlal Nehru Med Coll, Wardha, India.
C3 Datta Meghe Institute of Higher Education & Research (Deemed to be
   University); Jawaharlal Nehru Medical College Wardha; Datta Meghe
   Institute of Higher Education & Research (Deemed to be University);
   Jawaharlal Nehru Medical College Wardha
RP Madaan, S (corresponding author), Datta Meghe Inst Med Sci, Jawaharlal Nehru Med Coll, Dept Obstet & Gynaecol, Wardha, India.
EM sparsh19madaan@gmail.com
RI Talwar, Dhruv/AAC-9554-2020; Acharya, Neema/AAZ-6872-2020; JAISWAL,
   ARPITA/ABA-8385-2020; Kumar, Sunil/AAI-2286-2019
OI Talwar, Dhruv/0000-0003-1643-9109; MADAAN, SPARSH/0000-0002-1634-9608;
   Kumar, Sunil/0000-0001-9905-4831
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NR 36
TC 16
Z9 17
U1 1
U2 17
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
EI 2168-8184
J9 CUREUS J MED SCIENCE
JI Cureus J Med Sci
PD NOV 16
PY 2021
VL 13
IS 11
AR e19649
DI 10.7759/cureus.19649
PG 7
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA XC9BU
UT WOS:000722306600006
PM 34956769
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Choi, EK
   Rajasekaran, M
   Sul, OJ
   Joe, Y
   Chung, HT
   Yu, R
   Choi, HS
AF Choi, Eun-Kyung
   Rajasekaran, Monisha
   Sul, Ok-Joo
   Joe, Yeonsoo
   Chung, Hyun-Taeg
   Yu, Rina
   Choi, Hye-Seon
TI Impaired insulin signaling upon loss of ovarian function is associated
   with a reduction of tristetraprolin and an increased stabilization of
   chemokine in adipose tissue
SO MOLECULAR AND CELLULAR ENDOCRINOLOGY
LA English
DT Article
DE Impaired insulin signaling; TIT; Loss of ovarian function; Chemokines;
   Adipose tissue
ID MONOCYTE CHEMOATTRACTANT PROTEIN-1; INFLAMMATION-RELATED GENES; NONOBESE
   PIMA-INDIANS; DIET-INDUCED OBESITY; FAT-FED RATS; MESSENGER-RNA;
   MACROPHAGE-INFILTRATION; INCREASED EXPRESSION; OVARIECTOMIZED MICE;
   METABOLIC SYNDROME
AB Loss of ovarian function can activate inflammation and lead to insulin resistance (IR). IR is also a core feature of obesity and obesity-associated metabolic dysfunction. Tristetraprolin/zinc finger protein 36 (TTP) interferes with TNF-alpha production by destabilizing TNF-alpha. mRNA, and mice deficient in TTP develop a complex syndrome of inflammatory disease (Carballo et al., 1998; Taylor et al., 1999). We hypothesized that ovariectomy (OVX) might also prime inflammation by reducing tristetraprolin/zinc finger protein 36 (TTP) levels. We used a mouse OVX model to study impaired insulin signaling due to loss of ovarian function by evaluating Akt activity upon insulin stimulus. Impaired insulin signaling was initially detected in adipose tissue (AT) at 4 weeks after OVX, and then spread to liver and muscle, finally resulting in systemic IR at 12 weeks after OVX. OVX decreased TTP protein levels and increased adipocyte size, oxidative stress, chemokine expression and fat mass in AT by 4 weeks after surgery. TIP deficiency due to TTP gene deletion induced aberrant insulin signaling and increased chemokine expression and macrophage numbers in AT but did not increase adipocyte size, oxidative stress, or fat mass, suggesting that it promotes insulin signaling by decreasing AT inflammation independent of oxidative stress and adiposity. OVX, like TTP deficiency, increased the stability of chemokine transcripts as assessed from their half-lives. Our data indicate that the impaired insulin signaling resulting from OVX is due to an OVX-induced reduction of TTP and the resulting stabilization of inflammatory chemokines. (C) 2017 Elsevier B.V. All rights reserved.
C1 [Choi, Eun-Kyung; Rajasekaran, Monisha; Sul, Ok-Joo; Joe, Yeonsoo; Chung, Hyun-Taeg; Choi, Hye-Seon] Univ Ulsan, Dept Biol Sci, Ulsan 680749, South Korea.
   [Yu, Rina] Univ Ulsan, Dept Food Sci & Nutr, Ulsan 680749, South Korea.
   [Choi, Eun-Kyung] Univ Michigan, Dept Mol & Integrat Physiol, Ann Arbor, MI 48109 USA.
C3 University of Ulsan; University of Ulsan; University of Michigan System;
   University of Michigan
RP Choi, HS (corresponding author), Univ Ulsan, Dept Biol Sci, Ulsan 680749, South Korea.
EM hschoi@mail.ulsan.ac.kr
RI Sul, Onejae/U-9544-2019; choi, eunkyung/JUF-8150-2023
OI Sul, Ok Joo/0000-0002-8517-0898; rajasekaran,
   monisha/0000-0003-2046-7727; Choi, Hye-Seon/0000-0003-2992-2677
FU Basic Science Research Program of the National Research Foundation of
   Korea (NRF) - Korean government [2015R1A2A2A01002417]; Basic Science
   Research Program through the NRF - Ministry of Education
   [2016R1A6A3A11932375, 2014R1A6A1030318]
FX This work was supported by the Basic Science Research Program
   (2015R1A2A2A01002417) of the National Research Foundation of Korea (NRF)
   funded by the Korean government. EKC, MR (2014R1A6A1030318) and OJS
   (2016R1A6A3A11932375) were supported by the Basic Science Research
   Program through the NRF funded by the Ministry of Education.
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NR 46
TC 8
Z9 8
U1 0
U2 6
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0303-7207
J9 MOL CELL ENDOCRINOL
JI Mol. Cell. Endocrinol.
PD FEB 5
PY 2018
VL 461
IS C
BP 122
EP 131
DI 10.1016/j.mce.2017.09.002
PG 10
WC Cell Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Endocrinology & Metabolism
GA FV1GJ
UT WOS:000424309100013
PM 28887124
DA 2025-06-11
ER

PT J
AU Vlassara, H
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   Shobha, MS
   Uribarri, J
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AF Vlassara, H.
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TI Managing Chronic Inflammation in the Aging Diabetic Patient With CKD by
   Diet or Sevelamer Carbonate: A Modern Paradigm Shift
SO JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL
   SCIENCES
LA English
DT Article
DE Diabetes; Hemodialysis; AGEs; Diet; Inflammation; Aging
ID GLYCATION END-PRODUCTS; ACUTE KIDNEY INJURY; STAGE RENAL-DISEASE; TNF
   RECEPTORS 1; OXIDATIVE-STRESS; METABOLIC SYNDROME; OXIDANT STRESS;
   ENDOTHELIAL DYSFUNCTION; GLYCOXIDATION PRODUCTS; INSULIN-RESISTANCE
AB The maintenance of normal metabolism and body defenses depends on the balance between cellular antioxidant and anti-inflammatory factors. This balance can be disrupted by agents/mechanisms in the extracellular milieu that induce excess reactive oxygen species (ROS) and inflammation. Cytopathic advanced glycation endproducts, present in ever increasing amounts in the modern diet, are one of the major environmental factors that cause excess ROS and/or inflammation at all ages and induce complications in aging, such as chronic kidney disease (CKD) and type 2 diabetes. Increased ROS and/or inflammation are present in both aging and CKD, and are associated with reduced cellular defenses against ROS and/or inflammation. Affected individuals have reduced defenses against further stress and are predisposed to organ failure, now a well-known phenomenon in aging. Thus, new methods are urgently needed to safely reduce ROS and/or inflammation in the aging type 2 diabetes patient with CKD. Studies of both normal aging and diabetic patients with kidney disease underline the fact that increased ROS and/or inflammation can be managed in these conditions by economical, safe, and effective interventions that reduce the uptake of advanced glycation endproducts by either modifying preparation of food or an oral drug. This communication reviews these data and adds new information on the efficacy of a drug, sevelamer carbonate, required to reduce ROS and/or inflammation in the aging type 2 diabetes patient complicated by CKD. If larger and longer studies confirm the hypothesis that one or both of these interventions reduce progression of CKD, it could represent a new paradigm in the management of complications in the type 2 diabetes patient with CKD.
C1 [Vlassara, H.; Cai, W.; Chen, X.; Serrano, E. J.; Shobha, M. S.; Uribarri, J.; Striker, G. E.] Mt Sinai Sch Med, Dept Geriatr & Palliat Care, Div Expt Diabet & Aging, New York, NY 10029 USA.
   [Uribarri, J.; Striker, G. E.] Mt Sinai Sch Med, Dept Med, Div Nephrol, New York, NY 10029 USA.
   [Woodward, M.] George Inst Global Hlth, Camperdown, NSW 2050, Australia.
C3 Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at
   Mount Sinai; George Institute for Global Health
RP Vlassara, H (corresponding author), Mt Sinai Sch Med, Dept Geriatr & Palliat Care, Div Expt Diabet & Aging, 1 Gustave Levy Pl, New York, NY 10029 USA.
EM helen.vlassara@mssm.edu
RI Woodward, Mark/L-6817-2017; Uribarri, Jaime/ADX-7655-2022; YUBERO,
   ELENA/AFM-2738-2022
OI Woodward, Mark/0000-0001-9800-5296; Yubero-Serrano, Elena
   M/0000-0002-2733-5359
FU National Institutes of Health [RO1AG0099453, AG23188, R01DK09123]
FX National Institutes of Health, RO1AG0099453, AG23188, and R01DK09123
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NR 57
TC 23
Z9 25
U1 0
U2 9
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1079-5006
J9 J GERONTOL A-BIOL
JI J. Gerontol. Ser. A-Biol. Sci. Med. Sci.
PD DEC
PY 2012
VL 67
IS 12
BP 1410
EP 1416
DI 10.1093/gerona/gls195
PG 7
WC Geriatrics & Gerontology; Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA 040ES
UT WOS:000311305000021
PM 23109677
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Vukovic, J
   Modun, D
   Budimir, D
   Sutlovic, D
   Salamunic, I
   Zaja, I
   Boban, M
AF Vukovic, Jonatan
   Modun, Darko
   Budimir, Danijela
   Sutlovic, Davorka
   Salamunic, Ilza
   Zaja, Ivan
   Boban, Mladen
TI Acute, food-induced moderate elevation of plasma uric acid protects
   against hyperoxia-induced oxidative stress and increase in arterial
   stiffness in healthy humans
SO ATHEROSCLEROSIS
LA English
DT Article
DE Uric acid; Oxidative stress; Hyperoxia; Augmentation index; Red wine;
   Vascular activity
ID LIPID-PEROXIDATION PRODUCTS; SERUM ANTIOXIDANT CAPACITY; RED WINE
   CONSUMPTION; VITAMIN-C; CARDIOVASCULAR RISK; ENDOTHELIAL FUNCTION;
   OXYGEN; DISEASE; URATE; EXERCISE
AB We examined the effects of acute, food-induced moderate increase of plasma uric acid (UA) on arterial stiffness and markers of oxidative damage inplasma in healthy males exposed to 100% normobaric oxygen. Acute elevation of plasma UA was induced by consumption of red wine, combination of ethanol and glycerol, or fructose. By using these beverages we were able to separate the effects of UA, wine polyphenols and ethanol. Water was used as a control beverage. Ten males randomly consumed test beverages in a cross-over design over the period of 4 weeks, one beverage per week. They breathed 100% O-2 between 60(th) and 90(th) min of the 4-h study protocol. Pulse wave augmentation index (AIx) at brachial and radial arteries, plasma antioxidant capacity (AOC), thiobarbituric acid-reactive substances (TBARS), lipid hydroperoxides (LOOH) assessed by xylenol orange method, UA and blood ethanol concentrations were determined before and 60, 90, 120, 150 and 240 min after beverage consumption. Consumption of the beverages did not affect the AIx, TBARS or LOOH values during 60 min before exposure to hyperoxia, while AOC and plasma UA increased except in the water group. Significant increase of AIx, plasma TBARS and LOOH, which occurred during 30 min of hyperoxia in the water group, was largely prevented in the groups that consumed red wine, glycerol + ethanol or fructose. In contrast to chronic hyperuricemia, generally considered as a risk factor for cardiovascular diseases and metabolic syndrome, acute increase of UA acts protectively against hyperoxia-induced oxidative stress and related increase of arterial stiffness in large peripheral arteries. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
C1 [Vukovic, Jonatan; Modun, Darko; Budimir, Danijela; Zaja, Ivan; Boban, Mladen] Univ Split, Sch Med, Dept Pharmacol, Split 21000, Croatia.
   [Sutlovic, Davorka] Univ Hosp Split, Dept Pathol & Forens Med, Split 21000, Croatia.
   [Salamunic, Ilza] Univ Hosp Split, Dept Lab Diagnost, Split 21000, Croatia.
C3 University of Split; University of Split; University of Split
RP Boban, M (corresponding author), Univ Split, Sch Med, Dept Pharmacol, Soltanska 2, Split 21000, Croatia.
EM mladen.boban@mefst.hr
RI Zaja, Ivan/N-1330-2015; Sutlovic, Davorka/AAA-1432-2019; Vuković,
   Jonatan/KGL-8697-2024; Modun, Darko/AAG-5988-2021; Modun,
   Darko/D-8590-2017; Boban, Mladen/E-2777-2017
OI Budimir Mrsic, Danijela/0000-0003-1362-2901; Sutlovic,
   Davorka/0000-0002-9899-5119; Vukovic, Jonatan/0000-0002-7878-7988;
   Modun, Darko/0000-0001-9508-9383; Boban, Mladen/0000-0003-1570-9621
FU Ministry of Science, Education and Sports of the Republic of Croatia
   [216-2160547-0537]
FX This work was supported by grant 216-2160547-0537 from the Ministry of
   Science, Education and Sports of the Republic of Croatia. We thank
   Antonela Sliskovic, Nikolina Turudic and Svjetlana Dosenovic for their
   technical assistance. We especially thank Mr. Enver Moralic for the
   donation of wine used in this study.
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NR 55
TC 30
Z9 32
U1 0
U2 9
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0021-9150
EI 1879-1484
J9 ATHEROSCLEROSIS
JI Atherosclerosis
PD NOV
PY 2009
VL 207
IS 1
BP 255
EP 260
DI 10.1016/j.atherosclerosis.2009.04.012
PG 6
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 528QE
UT WOS:000272460700041
PM 19457484
DA 2025-06-11
ER

PT J
AU Rashki, M
   Rahbardar, MG
   Boskabady, MH
AF Rashki, Mostafa
   Rahbardar, Mahboobeh Ghasemzadeh
   Boskabady, Mohammad Hossein
TI Nutritional Advantages of Walnut (Juglans regia L.) for
   Cardiovascular Diseases: A Comprehensive Review
SO FOOD SCIENCE & NUTRITION
LA English
DT Review
DE blood pressure; inflammation; Juglans regia; oxidative
   stress; stroke; thrombosis; walnut
ID CORONARY-HEART-DISEASE; OXIDATIVE STRESS; PLATELET ACTIVATION; METABOLIC
   SYNDROME; MEDICINAL-PLANTS; INTERNAL SEPTUM; LIPID PROFILES;
   NITRIC-OXIDE; ACID; CHOLESTEROL
AB Cardiovascular diseases (CVDs) remain one of the leading causes of morbidity and mortality worldwide. In recent years, the potential role of dietary interventions in preventing and managing CVDs has gained significant attention. Among these dietary components, walnuts (Juglans regia L.) have emerged as a promising candidate due to their unique nutrient profile and potential cardiovascular benefits. This review aims to provide a comprehensive analysis of the existing literature on the role of walnuts in cardiovascular health. Using databases from Scopus, Google Scholar, and PubMed, the most relevant in vitro, in vivo, and clinical trial research has been collected from the time of inception until 2024. Several studies have shown that walnut consumption has a positive effect on a variety of cardiovascular risk factors. Walnut bioactive ingredients, including omega-3 fatty acids, antioxidants, fiber, and polyphenols, have been demonstrated to improve lipid profiles, blood pressure, endothelial function, inflammation, oxidative stress, and thrombosis. These processes all contribute to the possible cardioprotective properties of walnuts. Epidemiological and clinical research indicates that daily walnut consumption can reduce the risk of CVDs like coronary heart disease and stroke. Walnuts may aid in managing CVDs through mechanisms such as enhancing lipid profiles, reducing inflammation, and improving overall cardiovascular function. This review highlights the potential role of walnuts as a dietary strategy for the prevention and management of CVDs. Further understanding of the mechanisms and long-term effects of walnut consumption is crucial for optimizing their therapeutic potential and integrating them into clinical practice. Future research should focus on elucidating specific dose-response relationships and exploring the synergistic effects of walnuts in combination with other dietary and lifestyle interventions.
C1 [Rashki, Mostafa; Rahbardar, Mahboobeh Ghasemzadeh; Boskabady, Mohammad Hossein] Mashhad Univ Med Sci, Appl Biomed Res Ctr, Mashhad, Iran.
   [Boskabady, Mohammad Hossein] Mashhad Univ Med Sci, Fac Med, Dept Physiol, Mashhad, Iran.
C3 Mashhad University of Medical Sciences; Mashhad University of Medical
   Sciences
RP Boskabady, MH (corresponding author), Mashhad Univ Med Sci, Appl Biomed Res Ctr, Mashhad, Iran.; Boskabady, MH (corresponding author), Mashhad Univ Med Sci, Fac Med, Dept Physiol, Mashhad, Iran.
EM boskabadymh@mums.ac.ir
RI Boskabady, Mohammad/AAR-5552-2021; Ghasemzadeh Rahbardar,
   Mahboobeh/V-4452-2019
OI Ghasemzadeh Rahbardar, Mahboobeh/0000-0002-5491-572X; Boskabady,
   Mohammad Hossein/0000-0001-5736-9755
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NR 158
TC 1
Z9 1
U1 11
U2 11
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2048-7177
J9 FOOD SCI NUTR
JI Food Sci. Nutr.
PD JAN
PY 2025
VL 13
IS 1
AR e4526
DI 10.1002/fsn3.4526
PG 21
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA S2B9I
UT WOS:001396354500001
PM 39803290
OA hybrid
DA 2025-06-11
ER

PT J
AU Ishitobi, T
   Hyogo, H
   Tokumo, H
   Arihiro, K
   Chayama, K
AF Ishitobi, Tomokazu
   Hyogo, Hideyuki
   Tokumo, Hironori
   Arihiro, Koji
   Chayama, Kazuaki
TI Efficacy of probucol for the treatment of non-alcoholic steatohepatitis
   with dyslipidemia: An open-label pilot study
SO HEPATOLOGY RESEARCH
LA English
DT Article
DE probucol; oxidative stress; dyslipidemia; non-alcoholic steatohepatitis
ID FATTY LIVER-DISEASE; GLYCATION END-PRODUCTS; INSULIN-RESISTANCE;
   METABOLIC SYNDROME; DIABETES-MELLITUS; FOLLOW-UP; PROGRESSION;
   COMMITTEE; SEVERITY; FIBROSIS
AB Aim
   Oxidative stress plays a pivotal role in the transition from simple steatosis to non-alcoholic steatohepatitis (NASH). Probucol is a lipid-lowering agent with strong antioxidant properties, and is reported to be effective for the treatment of NASH in several studies. The aim of the present study was to evaluate the efficacy of probucol for the treatment of NASH with dyslipidemia.
   Methods
   Twenty-six patients with biopsy-proven NASH accompanied by dyslipidemia were treated with 500 mg of probucol daily for 48 weeks. Body mass index, visceral fat area, liver function tests, serum lipids, fibrosis markers, ferritin, adiponectin, leptin, urinary 8-hydroxy-2 '-deoxyguanosine (U-8OHdG) and elasticity were measured periodically during the study. Follow-up liver biopsy was performed in 18 patients.
   Results
   Serum levels of aminotransferases, total cholesterol and U-8OHdG significantly decreased (P < 0.01). Levels of hemoglobin A1c (HbA1c), the Homeostasis Model of Assessment - Insulin Resistance index and serum levels of ferritin, type IV collagen 7S and hyaluronic acid significantly decreased (P < 0.05). The serum levels of adiponectin tended to be increased. Liver stiffness significantly decreased from 8.8 +/- 6.8 to 6.6 +/- 4.0 kPa (P < 0.01). Non-alcoholic fatty liver disease activity scores were significantly improved from 4.2 +/- 1.4 to 3.4 +/- 1.6 (P < 0.05) and fibrotic stages tended to be improved from 1.6 +/- 0.8 to 1.3 +/- 1.1, respectively. No adverse effects of this treatment were noted.
   Conclusion
   Probucol improved clinical and histological findings probably through its ability to reduce insulin resistance and oxidative stress. Probucol therapy was safe and effective for Japanese NASH patients with dyslipidemia.
C1 [Ishitobi, Tomokazu; Hyogo, Hideyuki; Chayama, Kazuaki] Hiroshima Univ, Grad Sch Biomed Sci, Dept Med & Mol Sci, Hiroshima 7348551, Japan.
   [Arihiro, Koji] Hiroshima Univ, Grad Sch Biomed Sci, Dept Pathol, Hiroshima 7348551, Japan.
   [Tokumo, Hironori] JA Hiroshima Gen Hosp, Dept Gastroenterol & Hepatol, Hiroshima, Japan.
C3 Hiroshima University; Hiroshima University
RP Hyogo, H (corresponding author), Hiroshima Univ, Grad Sch Biomed Sci, Dept Med & Mol Sci, Minami Ku, 1-2-3 Kasumi, Hiroshima 7348551, Japan.
EM hidehyogo@hiroshima-u.ac.jp
RI Chayama, Kazuaki/B-2493-2016
OI Chayama, Kazuaki/0000-0002-5530-5341
FU Grants-in-Aid for Scientific Research [25670369] Funding Source: KAKEN
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NR 47
TC 11
Z9 12
U1 0
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1386-6346
EI 1872-034X
J9 HEPATOL RES
JI Hepatol. Res.
PD APR
PY 2014
VL 44
IS 4
BP 429
EP 435
DI 10.1111/hepr.12135
PG 7
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA AE0DC
UT WOS:000333632700010
PM 23607264
DA 2025-06-11
ER

PT J
AU Kochi, T
   Shimizu, M
   Terakura, D
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   Ohno, T
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   Tsurumi, H
   Tanaka, T
   Moriwaki, H
AF Kochi, Takahiro
   Shimizu, Masahito
   Terakura, Daishi
   Baba, Atsushi
   Ohno, Tomohiko
   Kubota, Masaya
   Shirakami, Yohei
   Tsurumi, Hisashi
   Tanaka, Takuji
   Moriwaki, Hisataka
TI Non-alcoholic steatohepatitis and preneoplastic lesions develop in the
   liver of obese and hypertensive rats: Suppressing effects of EGCG on the
   development of liver lesions
SO CANCER LETTERS
LA English
DT Article
DE Obesity; Hypertension; Liver fibrosis; Liver tumorigenesis; EGCG
ID RENIN-ANGIOTENSIN SYSTEM; GREEN TEA CATECHINS; (-)-EPIGALLOCATECHIN
   GALLATE SUPPRESSES; DIABETIC C57BL/KSJ-DB/DB MICE;
   HEPATOCELLULAR-CARCINOMA; METABOLIC SYNDROME; RECEPTOR BLOCKER;
   OXIDATIVE STRESS; FIBROSIS; PREVENTION
AB Non-alcoholic steatohepatitis (NASH), which involves hepatic inflammation and fibrosis, is associated with liver carcinogenesis. The activation of the renin-angiotensin system (RAS), which plays a key role in blood pressure regulation, promotes hepatic fibrogenesis. In this study, we investigated the effects of (-)-epigallocatechin-3-gallate (EGCG), a major component of green tea catechins, on the development of glutathione S-transferase placental form (GST-P)-positive (GST-P+) foci, a hepatic preneoplastic lesion, in SHRSP.Z-Lepr(fa)/IzmDmcr (SHRSP-ZF) obese and hypertensive rats. Male 7-week-old SHRSP-ZF rats and control non-obese and normotensive WRY rats were fed a high fat diet and received intraperitoneal injections of carbon tetrachloride twice a week for 8 weeks. The rats were also provided tap water containing 0.1% EGCG during the experiment. SHRSP-ZF rats presented with obesity, insulin resistance, dyslipidemia, an imbalance of adipokines in the serum, and hepatic steatosis. The development of GST-P+ foci and liver fibrosis was markedly accelerated in SHRSP-ZF rats compared to that in control rats. Additionally, in SHRSP-ZF rats, RAS was activated and inflammation and oxidative stress were induced. Administration of EGCG, however, inhibited the development of hepatic premalignant lesions by improving liver fibrosis, inhibiting RAS activation, and attenuating inflammation and oxidative stress in SHRSP-ZF rats. In conclusion, obese and hypertensive SHRSP-ZF rats treated with a high fat diet and carbon tetrachloride displayed the histopathological and pathophysiological characteristics of NASH and developed GST-P+ foci hepatic premalignant lesions, suggesting the model might be useful for the evaluation of NASH-related liver tumorigenesis. EGCG might also be able to prevent NASH-related liver fibrosis and tumorigenesis. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
C1 [Kochi, Takahiro; Shimizu, Masahito; Terakura, Daishi; Baba, Atsushi; Ohno, Tomohiko; Kubota, Masaya; Shirakami, Yohei; Tsurumi, Hisashi; Moriwaki, Hisataka] Gifu Univ, Grad Sch Med, Dept Med, Gifu 5011194, Japan.
   [Tanaka, Takuji] Gifu Univ, Grad Sch Med, Dept Tumor Pathol, Gifu 5011194, Japan.
C3 Gifu University; Gifu University
RP Shimizu, M (corresponding author), Gifu Univ, Grad Sch Med, Dept Gastroenterol, 1-1 Yanagido, Gifu 5011194, Japan.
EM shimim-gif@umin.ac.jp
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NR 52
TC 47
Z9 51
U1 2
U2 29
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0304-3835
EI 1872-7980
J9 CANCER LETT
JI Cancer Lett.
PD JAN 1
PY 2014
VL 342
IS 1
BP 60
EP 69
DI 10.1016/j.canlet.2013.08.031
PG 10
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA 274FB
UT WOS:000328591100008
PM 23981577
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Indulekha, K
   Surendar, J
   Anjana, RM
   Gokulakrishnan, K
   Balasubramanyam, M
   Aravindhan, V
   Mohan, V
AF Indulekha, K.
   Surendar, J.
   Anjana, R. M.
   Gokulakrishnan, K.
   Balasubramanyam, M.
   Aravindhan, V.
   Mohan, V.
TI Circulating levels of high molecular weight (HMW) adiponectin and total
   adiponectin in relation to fat distribution, oxidative stress and
   inflammation in Asian Indians
SO DISEASE MARKERS
LA English
DT Article
DE Metabolic syndrome; obesity; type 2 diabetes; Asian Indians;
   adipocytokines
ID NECROSIS-FACTOR-ALPHA; INSULIN-RESISTANCE; SENSITIVITY; ATHEROSCLEROSIS;
   ACTIVATION; MARKERS; PROTEIN
AB Aim: To look at the association of total and high molecular weight (HMW) adiponectin with markers of fat distribution, oxidative stress and inflammation in Asian Indians.
   Methods: A total of 120 subjects were chosen randomly from Chennai Urban Rural Epidemiological Study. Fasting HMW adiponectin levels, TNF-alpha and oxidized LDL were measured using ELISA. High sensitivity C reactive protein (hsCRP) was measured by a high sensitive nephelometric assay. Lipid peroxidation was measured by Tbars assay and protein carbonyl content was assessed by DNPH assay. Visceral and subcutaneous fat areas were assessed by computed tomography (CT) scan.
   Results: When stratified based on the tertiles of visceral fat, the levels of total (p = 0.03) and HMW adiponectin(p = 0.007) were highest in the first tertile followed by tertiles 2 and 3 whereas in tertiles of subcutaneous fat, there was no such trend. With increasing tertiles of Tbars, the levels of total (p = 0.03) and HMW adiponectin decreased (p = 0.002). The levels of HMW (p < 0.001) but not total adiponectin was also found to decrease with increasing tertiles of Protein carbonyl content. The levels of Total (p = 0.02) and HMW adiponectin (p = 0.004) were highest in the first tertile of oxidized LDL followed by tertile 2 and tertile 3. With increasing tertiles of TNF-alpha total (p = 0.01) and HMW adiponectin (p = 0.004) was found to decrease. With increasing tertiles of hs-CRP, Total (p = 0.005) and HMW adiponectin (p = 0.007) was found to decrease.
   Conclusion: Oxidative stress markers, visceral but not subcutaneous fat and inflammation are associated with total and HMW adiponectin levles in Asian Indians.
C1 [Indulekha, K.; Surendar, J.; Anjana, R. M.; Gokulakrishnan, K.; Balasubramanyam, M.; Mohan, V.] Madras Diabet Res Fdn, Chennai 600086, Tamil Nadu, India.
   [Indulekha, K.; Surendar, J.; Anjana, R. M.; Gokulakrishnan, K.; Balasubramanyam, M.; Mohan, V.] Int Diab Federat Ctr Educ, WHO Collaborating Ctr Noncommunicable Dis Preven, Dr Mohans Diab Special Ctr, Chennai 600086, Tamil Nadu, India.
   [Aravindhan, V.] Anna Univ, KB Chandrashekar Res Ctr, Lab Mol Immunol, Chennai 600025, Tamil Nadu, India.
C3 Madras Diabetes Research Foundation; Anna University; Anna University
   Chennai
RP Mohan, V (corresponding author), Madras Diabet Res Fdn, 4 Conran Smith Rd, Chennai 600086, Tamil Nadu, India.
EM drmohans@diabetes.ind.in
RI Viswanathan, Mohan/C-2321-2009; GOKULAKRISHNAN, KUPPAN/AAT-3244-2020
OI GOKULAKRISHNAN, KUPPAN/0000-0003-3167-8239; Aravindhan,
   Vivekanandhan/0000-0002-5639-4948; Mohan,
   Viswanathan/0000-0001-5038-6210; Karunakaran,
   Indulekha/0000-0002-4014-4880
FU Chennai Willingdon corporate foundation, Chennai
FX We are grateful to the Chennai Willingdon corporate foundation, Chennai,
   for the financial support and the epidemiology team members for
   conducting the field studies. This is the 94th paper from CURES.
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NR 28
TC 12
Z9 12
U1 0
U2 3
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 0278-0240
EI 1875-8630
J9 DIS MARKERS
JI Dis. Markers
PY 2012
VL 33
IS 4
BP 185
EP 192
DI 10.1155/2012/672939
PG 8
WC Biotechnology & Applied Microbiology; Genetics & Heredity; Medicine,
   Research & Experimental; Pathology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Genetics & Heredity; Research &
   Experimental Medicine; Pathology
GA 035VT
UT WOS:000310979700004
PM 22960344
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Peairs, AD
   Rankin, JW
   Lee, YW
AF Peairs, Abigail D.
   Rankin, Janet W.
   Lee, Yong Woo
TI Effects of acute ingestion of different fats on oxidative stress and
   inflammation in overweight and obese adults
SO NUTRITION JOURNAL
LA English
DT Article
DE meal challenge; postprandial; endothelial activation; obesity;
   NF-kappa?K?B
ID FACTOR-KAPPA-B; IMPAIRED GLUCOSE-TOLERANCE; FISH-OIL SUPPLEMENTATION;
   ENDOTHELIAL DYSFUNCTION; MONONUCLEAR-CELLS; EICOSAPENTAENOIC ACID;
   LIPID-PEROXIDATION; DOCOSAHEXAENOIC ACID; TRANSCRIPTION FACTOR;
   METABOLIC SYNDROME
AB Background: Studies show that obese individuals have prolonged elevations in postprandial lipemia and an exacerbated inflammatory response to high fat meals, which can increase risk for cardiovascular diseases. As epidemiological studies indicate an association between type of fat and circulating inflammatory markers, the purpose of this study was to investigate the acute effect of different fat sources on inflammation and oxidative stress in overweight and obese individuals.
   Methods: Eleven overweight and obese subjects consumed three high fat milkshakes rich in monounsaturated fat (MFA), saturated fat (SFA), or long-chain omega 3 polyunsaturated fat (O3FA) in random order. Blood samples collected at baseline, 1, 2, 4, and 6 hours postprandial were analyzed for markers of inflammation (soluble intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), tumor necrosis factor-alpha (TNF-alpha), and C-reactive protein (CRP)), oxidative stress (8 epi-prostaglandin-F2 alpha (8-epi) and nuclear factor-kappa B (NF-kappa B)), and metabolic factors (glucose, insulin, non-esterified free fatty acids, and triglycerides (TG)).
   Results: O3FA enhanced NF-kB activation compared to SFA, but did not increase any inflammatory factors measured. Conversely, SFA led to higher ICAM-1 levels than MFA (p = 0.051), while MFA increased TG more than SFA (p < 0.05). CRP increased while TNF-alpha and 8-epi decreased with no difference between treatments.
   Conclusions: While most of the inflammatory factors measured had modest or no change following the meal, ICAM-1 and NF-kappa B responded differently by meal type. These results are provocative and suggest that type of fat in meals may differentially influence postprandial inflammation and endothelial activation.
C1 [Peairs, Abigail D.; Rankin, Janet W.] Virginia Polytech Inst & State Univ, Dept Human Nutr Foods & Exercise, Blacksburg, VA 24061 USA.
   [Lee, Yong Woo] Virginia Polytech Inst & State Univ, Sch Biomed Engn & Sci, Blacksburg, VA 24061 USA.
C3 Virginia Polytechnic Institute & State University; Virginia Polytechnic
   Institute & State University
RP Peairs, AD (corresponding author), Virginia Polytech Inst & State Univ, Dept Human Nutr Foods & Exercise, Blacksburg, VA 24061 USA.
EM Abigail.peairs@uc.edu
FU National Science Foundation [DGE-0333378]
FX We acknowledge Nature's Bounty for providing fish oil capsules for this
   study. The authors would like to thank Janet Rinehart for phlebotomy and
   laboratory assistance, Violet Russell for phlebotomy, Mary Andreae and
   Elizabeth Abbey for sample collection and preparation, Anjali Hirani for
   EMSA assistance, and Drs. Ginger L. Milne and Jason Morrow of the
   Eicosanoid Core Laboratory at Vanderbilt University for analysis of
   plasma 8-epi. Abigail Turpyn Peairs was supported by the Macromolecular
   Interfaces with Life Sciences (MILES) Integrative Graduate Education and
   Research Traineeship (IGERT) of the National Science Foundation under
   Agreement No. DGE-0333378.
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NR 55
TC 71
Z9 87
U1 0
U2 19
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1475-2891
J9 NUTR J
JI Nutr. J.
PD NOV 7
PY 2011
VL 10
AR 122
DI 10.1186/1475-2891-10-122
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 853DK
UT WOS:000297406200001
PM 22059644
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Preuss, HG
   Echard, B
   Yamashita, E
   Perricone, NV
AF Preuss, Harry G.
   Echard, Bobby
   Yamashita, Eiji
   Perricone, Nicholas V.
TI High Dose Astaxanthin Lowers Blood Pressure and Increases Insulin
   Sensitivity in Rats: Are These Effects Interdependent?
SO INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
LA English
DT Article
DE Astaxanthin; BP effect; Insulin resistance; Restraint stress;
   renin-angiotensin system
ID INDUCED HYPERTENSION; METABOLIC SYNDROME; FATTY; SUCROSE; PREVENTION;
   RESISTANCE; CHROMIUM; SYSTEM
AB The present investigation in Sprague-Dawley rats (SD) was designed to examine effects of astaxanthin (Asta) at different doses on elevated blood pressure (BP) and glucose-insulin perturbations produced by heavy sucrose ingestion. We also examined effects of Asta on BP during restraint stress. SD were divided into six groups each containing eight rats. All SD ate a basic diet of ground regular rat chow with sucrose added at 30% w/w. The Control group received only the basic diet containing added sucrose, while the other five groups each received the same diet with added test material: captopril, (30 mg/Kg), pioglitazone (15.0 mg/Kg), low Asta (25 mg/Kg), medium Asta (50 mg/kg) or high Asta (100 mg/Kg). Many tests were carried out to examine the mechanisms behind the effects of Asta on BP (serum ACE activity, losartan challenge, and LNAME challenge) and the glucose-insulin system (glucose tolerance, HOMA measurement, and insulin challenge). In SD, a relatively low dose of Asta decreased SBP, but produced no major changes in the glucose-insulin system simulating results from a previous study using Zucker Fatty Rats. Increasing the dose of Asta resulted in both a lowering of elevated systolic BP and enhanced insulin sensitivity determined by many different estimations. BP lowering was consistent with changes in the renin-angiotensin (RAS) and nitric oxide (NO) systems. At the examined doses of each, captopril lowered BP in SD without influencing glucose-insulin metabolism, whereas pioglitazone favorably affected glucose-insulin metabolism while showing essentially no effects on BP. Accordingly, Asta beneficially affects both sucrose-induced elevations of BP and insulin resistance at relatively high doses in SD. Also, Asta at higher doses lessens restraint stress, whereas, captopril and pioglitazone did not at the doses examined, even though they influenced the BP and glucose-insulin systems respectively.
C1 [Preuss, Harry G.; Echard, Bobby] Georgetown Univ, Med Ctr, Dept Biochem, Washington, DC 20057 USA.
   [Yamashita, Eiji] Fuji Chem Ind Co Ltd, Div Life Sci, Toyama 9300397, Japan.
   [Perricone, Nicholas V.] Michigan State Univ, Coll Human Med, E Lansing, MI 48824 USA.
C3 Georgetown University; Michigan State University; Michigan State
   University College of Human Medicine
RP Preuss, HG (corresponding author), Georgetown Univ, Med Ctr, Dept Biochem, Basic Sci Bldg,Room 231 B,4000 Reservoir Rd NW, Washington, DC 20057 USA.
EM preusshg@georgetown.edu
FU Perricone Charitable Foundation
FX The Perricone Charitable Foundation supported this work. Dr. Yamashita
   is employed by Fuji Chemicals of Japan who supplied the astaxanthin.
   Drs. Preuss, Echard and Perricone have no financial interest in the
   Astaxanthin product.
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NR 35
TC 52
Z9 57
U1 0
U2 4
PU IVYSPRING INT PUBL
PI LAKE HAVEN
PA PO BOX 4546, LAKE HAVEN, NSW 2263, AUSTRALIA
SN 1449-1907
J9 INT J MED SCI
JI Int. J. Med. Sci.
PY 2011
VL 8
IS 2
BP 126
EP 138
DI 10.7150/ijms.8.126
PG 13
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 735DG
UT WOS:000288393000005
PM 21326955
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Valtuena, S
   Pellegrini, N
   Franzini, L
   Bianchi, MA
   Ardigo, D
   Del Rio, D
   Piatti, P
   Scazzina, F
   Zavaroni, I
   Brighenti, F
AF Valtuena, Silvia
   Pellegrini, Nicoletta
   Franzini, Laura
   Bianchi, Marta A.
   Ardigo, Diego
   Del Rio, Daniele
   Piatti, PierMarco
   Scazzina, Francesca
   Zavaroni, Ivana
   Brighenti, Furio
TI Food selection based on total antioxidant capacity can modify
   antioxidant intake, systemic inflammation, and liver function without
   altering markers of oxidative stress
SO AMERICAN JOURNAL OF CLINICAL NUTRITION
LA English
DT Article
ID C-REACTIVE PROTEIN; GAMMA-GLUTAMYL-TRANSFERASE; CORONARY-HEART-DISEASE;
   CARDIOVASCULAR-DISEASE; ALANINE AMINOTRANSFERASE; LIPID-PEROXIDATION;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; ALPHA-TOCOPHEROL; VEGETABLE
   INTAKE
AB Background: It is unknown whether diets with a high dietary total antioxidant capacity (TAC) can modify oxidative stress, low-grade inflammation, or liver dysfunction, all of which are risk factors for type 2 diabetes and cardiovascular disease.
   Objective: We studied the effect of high-and low-TAC (HT and LT, respectively) diets on markers of antioxidant status, systemic inflammation, and liver dysfunction.
   Design: In a crossover intervention, 33 healthy adults (19 men, 14 women) received the HT and LT diets for 2 wk each. Dietary habits were checked with a 3-d food record during both diet periods and the washout period.
   Results: Fruit and vegetable, macronutrient, dietary fiber, and alcohol intakes did not differ significantly between the 2 diets, whereas dietary TAC, alpha-tocopherol, and ascorbic acid were significantly (P < 0.001) higher during the HT diet. Plasma a-tocopherol rose during the HT and decreased during the LT diet (P < 0.02 for difference) without changes in markers of oxidative stress except plasma malondialdehyde, which decreased unexpectedly during the LT diet (P < 0.05). Plasma high-sensitivity C-reactive protein, alanine aminotransferase, gamma-glutamyltranspeptidase, and alkaline phosphatase concentrations decreased during the HT compared with the LT diet (mean SEM for pre-post changes: -0.72 +/- 0.37 compared with 1.05 +/- 0.60 mg/L, P < 0.01; -1.73 +/- 1.02 compared with 2.33 +/- 2.58 U/L, P < 0.01; -2.12 +/- 1.45 compared with 5.15 +/- 2.98 U/L, P < 0.05; and 1.36 +/- 1.34 compared with 5.06 +/- 2.00 U/L, P < 0.01, respectively).
   Conclusion: Selecting foods according to their TAC markedly affects antioxidant intake and modulates hepatic contribution to systemic inflammation without affecting traditional markers of antioxidant status.
C1 [Brighenti, Furio] Univ Parma, Dept Publ Hlth, Human Nutr Unit, I-43100 Parma, Italy.
   [Valtuena, Silvia; Franzini, Laura; Ardigo, Diego; Zavaroni, Ivana] Univ Parma, Dept Internal Med & Biomed Sci, I-43100 Parma, Italy.
   [Piatti, PierMarco] Ist Sci San Raffaele, Diabetol Endocrinol & Metab Dis Unit, Div Med, I-20132 Milan, Italy.
C3 University of Parma; University of Parma; Vita-Salute San Raffaele
   University; IRCCS Ospedale San Raffaele
RP Brighenti, F (corresponding author), Univ Parma, Dept Publ Hlth, Human Nutr Unit, Via Volturno 39, I-43100 Parma, Italy.
EM furio.brighenti@unipr.it
RI Pellegrini, Nicoletta/F-5851-2010; ARDIGO, DIEGO/AAD-5928-2022; Piatti,
   Piermarco/AAN-3115-2020; Del Rio, Daniele/E-8696-2010; SCAZZINA,
   FRANCESCA/B-8466-2011; brighenti, furio/E-4174-2010
OI Del Rio, Daniele/0000-0001-5394-1259; Bianchi,
   Marta/0000-0002-3853-9031; SCAZZINA, FRANCESCA/0000-0002-5372-8658;
   Ardigo, Diego/0000-0003-1127-7999; brighenti, furio/0000-0001-8441-4611
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NR 51
TC 125
Z9 141
U1 0
U2 5
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0002-9165
EI 1938-3207
J9 AM J CLIN NUTR
JI Am. J. Clin. Nutr.
PD MAY
PY 2008
VL 87
IS 5
BP 1290
EP 1297
DI 10.1093/ajcn/87.5.1290
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 301EZ
UT WOS:000255880500027
PM 18469252
OA Bronze
DA 2025-06-11
ER

PT J
AU Al Asmari, AK
   Al Shehri, HA
   Khan, HA
   Al Omani, S
   Kadasah, SG
   Horaib, GB
   Al Buraidi, A
   Al Sharif, AA
   Mohammed, FS
   Abbasmanthiri, R
   Osman, NM
AF Al Asmari, Abdulrahman K.
   Al Shehri, Hamoud A.
   Khan, Haseeb A.
   Al Omani, Saud
   Kadasah, Saeed G.
   Horaib, Ghaleb B.
   Al Buraidi, Ahmed
   Al Sharif, Abdullah A.
   Mohammed, Fayez S.
   Abbasmanthiri, Rajamohamed
   Osman, Nasreddien M.
TI Serum Levels of Proinflammatory Biomarkers in Military Recruits with and
   without Metabolic Syndrome
SO MEDIATORS OF INFLAMMATION
LA English
DT Article
ID NECROSIS-FACTOR-ALPHA; MYELOPEROXIDASE LEVELS; ADIPOSE-TISSUE; OXIDATIVE
   STRESS; OBESE-PATIENTS; TNF-ALPHA; INFLAMMATION; RISK; INTERLEUKIN-6;
   ASSOCIATION
AB Objectives. Inflammatory mediators are associated with many chronic diseases; however, their role in metabolic syndrome (Met-S) is not well documented. We therefore aimed to compare the serum markers of inflammation including C-reactive protein (CRP), myeloperoxidase (MPO), interleukin-6 (IL-6), tumour necrosis factor alpha (TNF-alpha), and TNF-beta in young military recruits with and without Met-S. We hypothesized that any significant change in inflammatory markers between the two groups would indicate the role of inflammation in Met-S that would help in future directions for screening and treatment of Met-S. Design and Methods. A total of 2010 adult men, aged 18-30 years, were divided into two groups: with Met-S (N = 488) and without Met-S (N = 1522), according to the International Diabetes Federation definition. We compared the serum levels of inflammatory biomarkers between the two groups. We also studied the correlations between the inflammatory markers and the components of Met-S to explore the biomarker potential of inflammatory markers for screening of Met-S. Logistic regression analysis was performed to test the association between inflammatory markers and Met-S. Results. A large number of subjects in the Met-S group were suffering from obesity. Out of the 2010 total subjects, only 731 (36.4%) had normal fasting blood sugar (FBS), while the prevalence of prediabetes and diabetes was significantly higher in subjects with Met-S. We observed significant increases in serum levels of CRP, MPO, IL-6, and TNF-beta but not TNF-alpha in subjects with Met-S as compared to subjects without Met-S. All the markers of inflammation showed significant correlations with Met-S, triglycerides (TG), blood pressure, body mass index (BMI), and age; however, none of these markers were correlated with HDL. Logistic regression analysis showed a significant association between Met-S and inflammatory markers. Conclusions. Serum levels of CRP, MPO, IL-6, and TNF-beta are significantly increased in young adults with Met-S. This is probably the first study reporting TNF-beta levels in Met-S. Since a proinflammatory cascade precedes many years before the onset of cardiovascular disease, these inflammatory biomarkers could help in the monitoring of high-risk individuals with Met-S who will be requiring therapeutic intervention.
C1 [Al Asmari, Abdulrahman K.; Abbasmanthiri, Rajamohamed; Osman, Nasreddien M.] Minist Def, Med Serv Dept MSD, Sci Res Ctr, Riyadh, Saudi Arabia.
   [Al Shehri, Hamoud A.] Minist Def, Med Serv Dept MSD, Prince Sultan Cardiac Ctr, Adult Cardiol, Riyadh, Saudi Arabia.
   [Khan, Haseeb A.] King Saud Univ, Coll Sci, Dept Biochem, Riyadh 11451, Saudi Arabia.
   [Al Omani, Saud] Minist Def, Dept Surg, Med Serv Dept MSD, Prince Sultan Mil Med City, Riyadh, Saudi Arabia.
   [Kadasah, Saeed G.] Minist Def, Dept Psychiat, Med Serv Dept MSD, Prince Sultan Mil Med City, Riyadh, Saudi Arabia.
   [Horaib, Ghaleb B.] Minist Def, Dermatol Dept, Med Serv Dept MSD, Riyadh, Saudi Arabia.
   [Al Buraidi, Ahmed] Minist Def, Dept ENT, Med Serv Dept MSD, Prince Sultan Mil Med City, Riyadh, Saudi Arabia.
   [Al Sharif, Abdullah A.] Minist Def, Dept Dent, Med Serv Dept MSD, Prince Sultan Mil Med City, Riyadh, Saudi Arabia.
   [Mohammed, Fayez S.] Prince Sultan Mil Coll Hlth Sci, Dhahran, Saudi Arabia.
C3 Prince Sultan Cardiac Center; King Saud University; Prince Sultan
   Military Medical City; Prince Sultan Military Medical City; Prince
   Sultan Military Medical City; Prince Sultan Military Medical City;
   Prince Sultan Military College of Health Sciences
RP Al Asmari, AK (corresponding author), Minist Def, Med Serv Dept MSD, Sci Res Ctr, Riyadh, Saudi Arabia.
EM abdulrahman.alasmari@gmail.com; drmoshabek@hotmail.com;
   haseeb@ksu.edu.sa; saudomani@hotmail.com; skadasah@yahoo.com;
   ghoraib@msd.med.sa; aalburaidi36@hotmail.com; drendo2001@yahoo.com;
   fa2.fa2@hotmail.com; amohamed@psmmc.med.sa; nmaosman.1@gmail.com
RI Khan, Haseeb/E-3872-2014
OI Khan, Haseeb/0000-0001-6084-8589
FU Advanced and Strategic Technologies Program of King Abdulaziz City for
   Science and Technology (KACST), Saudi Arabia [14-MED59-63]
FX The authors would like to thank all the medical and paramedical staff
   associated with this project for their excellent services. The
   statistical data analysis by Ms. Nasira Asghar of the Scientific
   Research Center, Medical Services Department, is gratefully
   acknowledged. This project was financially supported by the Advanced and
   Strategic Technologies Program of King Abdulaziz City for Science and
   Technology (KACST), Saudi Arabia (Grant No. 14-MED59-63).
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NR 43
TC 1
Z9 1
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0962-9351
EI 1466-1861
J9 MEDIAT INFLAMM
JI Mediat. Inflamm.
PD APR 30
PY 2023
VL 2023
AR 4613842
DI 10.1155/2023/4613842
PG 6
WC Cell Biology; Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Immunology
GA F5PG6
UT WOS:000982858700001
PM 37168278
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Leermakers, ETM
   Darweesh, SKL
   Baena, CP
   Moreira, EM
   van Lent, DM
   Tielemans, MJ
   Muka, T
   Vitezova, A
   Chowdhury, R
   Bramer, WM
   Kiefte-de Jong, JC
   Felix, JF
   Franco, OH
AF Leermakers, Elisabeth T. M.
   Darweesh, Sirwan K. L.
   Baena, Cristina P.
   Moreira, Eduardo M.
   van Lent, Debora Melo
   Tielemans, Myrte J.
   Muka, Taulant
   Vitezova, Anna
   Chowdhury, Rajiv
   Bramer, Wichor M.
   Kiefte-de Jong, Jessica C.
   Felix, Janine F.
   Franco, Oscar H.
TI The effects of lutein on cardiometabolic health across the life course:
   a systematic review and meta-analysis
SO AMERICAN JOURNAL OF CLINICAL NUTRITION
LA English
DT Article
DE antioxidant; cardiometabolic health; life course; lutein; systematic
   review
ID NUTRITION EXAMINATION SURVEY; SERUM CAROTENOID CONCENTRATIONS; 3RD
   NATIONAL-HEALTH; C-REACTIVE PROTEIN; ACUTE MYOCARDIAL-INFARCTION; ARTERY
   RISK DEVELOPMENT; YOUNG-ADULTS CARDIA; INTIMA-MEDIA THICKNESS;
   CORONARY-HEART-DISEASE; METABOLIC SYNDROME
AB Background: The antioxidant lutein is suggested as being beneficial to cardiometabolic health because of its protective effect against oxidative stress, but evidence has not systematically been evaluated.
   Objective: We aimed to evaluate systematically the effects of lutein (intake or concentrations) on cardiometabolic outcomes in different life stages.
   Design: This is a systematic review with meta-analysis of literature published in MEDLINE, Embase, Cochrane Central, Web of Science, PubMed, and Google Scholar up to August 2014. Included were trials and cohort, case-control, and cross-sectional studies in which the association between lutein concentrations, dietary intake, or supplements and cardiometabolic outcomes was reported. Two independent investigators reviewed the articles.
   Results: Seventy-one relevant articles were identified that included a total of 387,569 participants. Only 1 article investigated the effects of lutein during pregnancy, and 3 studied lutein in children. Furthermore, 31 longitudinal, 33 cross-sectional, and 3 intervention studies were conducted in adults. Meta-analysis showed a lower risk of coronary heart disease (pooled RR: 0.88; 95% CI: 0.80, 0.98) and stroke (pooled RR: 0.82; 95% CI: 0.72, 0.93) for the highest compared with the lowest tertile of lutein blood concentration or intake. There was no significant association with type 2 diabetes mellitus (pooled RR: 0.97; 95% CI: 0.77, 1.22), but higher lutein was associated with a lower risk of metabolic syndrome (pooled RR: 0.75; 95% CI: 0.60, 0.92) for the highest compared with the lowest tertile. The literature on risk factors for cardiometabolic diseases showed that lutein might be beneficial for atherosclerosis and inflammatory markers, but there were inconsistent associations with blood pressure, adiposity, insulin resistance, and blood lipids.
   Conclusions: Our findings suggest that higher dietary intake and higher blood concentrations of lutein are generally associated with better cardiometabolic health. However, evidence mainly comes from observational studies in adults, whereas large-scale intervention studies and studies of lutein during pregnancy and childhood are scarce.
C1 [Leermakers, Elisabeth T. M.; Darweesh, Sirwan K. L.; Moreira, Eduardo M.; van Lent, Debora Melo; Tielemans, Myrte J.; Muka, Taulant; Vitezova, Anna; Kiefte-de Jong, Jessica C.; Felix, Janine F.; Franco, Oscar H.] Erasmus Univ, Med Ctr, Dept Epidemiol, Rotterdam, Netherlands.
   [Bramer, Wichor M.] Erasmus Univ, Med Ctr, Med Lib, Rotterdam, Netherlands.
   [Baena, Cristina P.] Pontificia Univ Catolica Parana, Sch Med, Curitiba, Parana, Brazil.
   [Chowdhury, Rajiv] Univ Cambridge, Dept Publ Hlth & Primary Care, Cardiovasc Epidemiol Unit, Cambridge, England.
   [Kiefte-de Jong, Jessica C.] Leiden Univ Coll, The Hague, Netherlands.
C3 Erasmus University Rotterdam; Erasmus MC; Erasmus University Rotterdam;
   Erasmus MC; Pontificia Universidade Catolica do Parana; University of
   Cambridge
RP Leermakers, ETM (corresponding author), Erasmus Univ, Med Ctr, Dept Epidemiol, Rotterdam, Netherlands.
EM e.leermakers@erasmusmc.nl
RI Chowdhury, Rajiv/AHB-1253-2022; Franco, Óscar/ABE-2305-2020; Kiefte-de
   Jong, Jessica/GLV-3216-2022; Baena, Cristina/W-6039-2019; Darweesh,
   Sirwan/ABG-8906-2021; Bramer, Wichor/P-5044-2014
OI Franco, Oscar/0000-0002-4606-4929; Baena, Cristina
   Pellegrino/0000-0002-5822-6622; Kiefte-de Jong,
   Jessica/0000-0002-8136-0918; Melo van Lent, Debora/0000-0002-7392-9289;
   Chowdhury, Rajiv/0000-0003-4881-5690; Muka, Taulant/0000-0003-3235-3073;
   Darweesh, Sirwan/0000-0002-4361-4593; Bramer, Wichor/0000-0003-2681-9180
FU Nestle Nutrition (Nestec Ltd.); Metagenics Inc.; AXA; Erasmus Mundus
   Western Balkans - European Commision; MRC [MR/L003120/1] Funding Source:
   UKRI
FX Supported by Nestle Nutrition (Nestec Ltd.), Metagenics Inc., and AXA
   (to ETML, DMvL, MJT, JCK-dJ, and OHF), and supported by Erasmus Mundus
   Western Balkans, a project funded by the European Commision (TM and AV).
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NR 99
TC 118
Z9 125
U1 1
U2 41
PU AMER SOC NUTRITION-ASN
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0002-9165
EI 1938-3207
J9 AM J CLIN NUTR
JI Am. J. Clin. Nutr.
PD FEB
PY 2016
VL 103
IS 2
BP 481
EP 494
DI 10.3945/ajcn.115.120931
PG 14
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA DC8JJ
UT WOS:000369465400024
PM 26762372
OA Bronze
DA 2025-06-11
ER

PT J
AU Shen, XF
   Yang, HL
   Yang, Y
   Zhu, XJ
   Sun, QX
AF Shen, Xiaofei
   Yang, Hongling
   Yang, Yang
   Zhu, Xianjun
   Sun, Qingxiang
TI The cellular and molecular targets of natural products against metabolic
   disorders: a translational approach to reach the bedside
SO MEDCOMM
LA English
DT Review
DE glucose/lipid metabolism; insulin resistance; metabolic disorders;
   metabolic inflammation; natural products; target identification
ID LIPID-METABOLISM; INSULIN-RESISTANCE; OXIDATIVE STRESS; ADIPOSE-TISSUE;
   OBESITY; INFLAMMATION; PROTEIN; INJURY; SREBP; PAQR3
AB Metabolic disorders, including obesity, dyslipidemia, diabetes, nonalcoholic fatty liver disease, and metabolic syndrome, are characterized by insulin resistance, abnormalities in circulating cholesterol and lipid profiles, and hypertension. The most common pathophysiologies of metabolic disorders are glucose/lipid metabolism dysregulation, insulin resistance, inflammatory response, and oxidative stress. Although several agents have been approved for the treatment of metabolic disorders, there is still a strong demand for more efficacious drugs with less side effects. Natural products have been critical sources of drug research and discovery for decades. However, the usefulness of bioactive natural products is often limited by incomplete understanding of their direct cellular targets. In this review, we highlight the current understanding of the established and emerging molecular mechanisms of metabolic disorders. We further summarize the therapeutic effects and underlying mechanisms of natural products on metabolic disorders, with highlights on their direct cellular targets, which are mainly implicated in the regulation of glucose/lipid metabolism, insulin resistance, metabolic inflammation, and oxidative stress. Finally, this review also covers the clinical studies of natural products in metabolic disorders. These progresses are expected to facilitate the application of these natural products and their derivatives in the development of novel drugs against metabolic disorders.
   Metabolic disorders seriously endanger the health of human beings. However, there are no approved drugs specific for metabolic disorders. Recently, sever natural products have been demonstrated to alleviate metabolic disorders, and also used as chemical probes to identify their functional targets, which are involved in insulin resistance, glycolipid metabolism, and metabolic inflammation. These developments may facilitate the discovery of natural product-based first-in-class therapeutics against metabolic disorders. image
C1 [Shen, Xiaofei] Chengdu Univ Tradit Chinese Med, Hosp Chengdu Univ Tradit Chinese Med, TCM Regulating Metab Dis Key Lab Sichuan Prov, Chengdu, Peoples R China.
   [Yang, Hongling] Univ Elect Sci & Technol China, Dept Nephrol, Chengdu, Peoples R China.
   [Yang, Hongling] Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Inst Nephrol, Sichuan Clin Res Ctr Kidney Dis, Chengdu, Peoples R China.
   [Yang, Yang; Sun, Qingxiang] Univ Elect Sci & Technol, Sichuan Prov Peoples Hosp, Dept Resp & Crit Care Med, Chengdu, Peoples R China.
   [Zhu, Xianjun] Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Ctr Med Genet, Sichuan Prov Key Lab Human Dis Gene Study, Chengdu 610072, Sichuan, Peoples R China.
   [Zhu, Xianjun] Univ Elect Sci & Technol, Sichuan Prov Peoples Hosp, Hlth Management Ctr, Chengdu, Peoples R China.
C3 Chengdu University of Traditional Chinese Medicine; University of
   Electronic Science & Technology of China; University of Electronic
   Science & Technology of China; Sichuan Provincial People's Hospital;
   University of Electronic Science & Technology of China; Sichuan
   Provincial People's Hospital; University of Electronic Science &
   Technology of China; Sichuan Provincial People's Hospital; Sichuan
   Provincial People's Hospital; University of Electronic Science &
   Technology of China
RP Yang, Y; Sun, QX (corresponding author), Univ Elect Sci & Technol, Sichuan Prov Peoples Hosp, Dept Resp & Crit Care Med, Chengdu, Peoples R China.; Zhu, XJ (corresponding author), Univ Elect Sci & Technol, Sichuan Prov Peoples Hosp, Hlth Management Ctr, Chengdu, Peoples R China.
EM 18981838300@189.cn; xjzhu@uestc.edu.cn; sunqingxiang@med.uestc.edu.cn
RI qing xiang, Sun/LFT-9215-2024; shen, xiaofei/LRT-1082-2024
OI Sun, Qingxiang/0000-0002-9474-8882
FU National Natural Science Foundation of China [82273850]; Key Projects of
   Sichuan Province [2022YFS0023]
FX National Natural Science Foundation of China, Grant/Award Number:
   82273850;Key Projects of Sichuan Province, Grant/Award Number:
   2022YFS0023
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NR 182
TC 5
Z9 5
U1 6
U2 13
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
EI 2688-2663
J9 MEDCOMM
JI MedComm
PD AUG
PY 2024
VL 5
IS 8
AR e664
DI 10.1002/mco2.664
PG 30
WC Medicine, Research & Experimental
WE Emerging Sources Citation Index (ESCI)
SC Research & Experimental Medicine
GA ZJ0P0
UT WOS:001274812900001
PM 39049964
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Hoong, CWS
   Chua, MWJ
AF Hoong, Caroline W. S.
   Chua, Marvin W. J.
TI SGLT2 Inhibitors as Calorie Restriction Mimetics: Insights on Longevity
   Pathways and Age-Related Diseases
SO ENDOCRINOLOGY
LA English
DT Review
DE SGLT2 inhibitors; aging; longevity; calorie restriction; cellular
   senescence
ID GLUCOSE COTRANSPORTER 2; FATTY LIVER-DISEASE; GROWTH-FACTOR-I; TYPE-2
   DIABETES-MELLITUS; BLOOD-PRESSURE; LIFE-SPAN; INSULIN-RESISTANCE;
   ARTERIAL STIFFNESS; RESVERATROL SUPPLEMENTATION; MITOCHONDRIAL-FUNCTION
AB Sodium-glucose cotransporter-2 (SGLT2) inhibitors induce glycosuria, reduce insulin levels, and promote fatty acid oxidation and ketogenesis. By promoting a nutrient deprivation state, SGLT2 inhibitors upregulate the energy deprivation sensors AMPK and SIRT1, inhibit the nutrient sensors mTOR and insulin/IGF1, and modulate the closely linked hypoxia-inducible factor (HIF)-2 alpha/HIF-1 alpha pathways. Phosphorylation of AMPK and upregulation of adiponectin and PPAR-alpha favor a reversal of the metabolic syndrome which have been linked to suppression of chronic inflammation. Downregulation of insulin/IGF1 pathways and mTOR signaling from a reduction in glucose and circulating amino acids promote cellular repair mechanisms, including autophagy and proteostasis which confer cellular stress resistance and attenuate cellular senescence. SIRT1, another energy sensor activated by NAD+ in nutrient-deficient states, is reciprocally activated by AMPK, and can deacetylate and activate transcription factors, such as PCG-1 alpha, mitochondrial transcription factor A (TFAM), and nuclear factor E2-related factor (NRF)-2, that regulate mitochondrial biogenesis. FOXO3 transcription factor which target genes in stress resistance, is also activated by AMPK and SIRT1. Modulation of these pathways by SGLT2 inhibitors have been shown to alleviate metabolic diseases, attenuate vascular inflammation and arterial stiffness, improve mitochondria! function and reduce oxidative stress-induced tissue damage. Compared with other calorie restriction mimetics such as metformin, rapamycin, resveratrol, and NAD+ precursors, SGLT2 inhibitors appear to be the most promising in the treatment of aging-related diseases, due to their regulation of multiple longevity pathways that closely resembles that achieved by calorie restriction and their established efficacy in reducing cardiovascular events and all-cause mortality. Evidence is compelling for the role of SGLT2 inhibitors as a calorie restriction mimetic in anti-aging therapeutics.
C1 [Hoong, Caroline W. S.] Woodlands Hlth Campus Singapore, Div Endocrinol, Natl Healthcare Grp Singapore, Dept Gen Med, Woodlands Hlth Campus, Singapore 768024, Singapore.
   [Chua, Marvin W. J.] Sengkang Gen Hosp Singapore, SingHlth Grp Singapore, Sengkang Gen Hosp, Dept Gen Med,Endocrinol Serv, Singapore 544886, Singapore.
RP Hoong, CWS (corresponding author), Woodlands Hlth Campus Singapore, Div Endocrinol, Natl Healthcare Grp Singapore, Dept Gen Med, Woodlands Hlth Campus, Singapore 768024, Singapore.; Hoong, CWS (corresponding author), Woodlands Hlth Campus Singapore, 2 Yishun Cent 2,Tower E Level 5, Singapore 768024, Singapore.
EM caroline_hoong@whc.sg
RI HOONG, CAROLINE/AAE-1313-2021
OI Hoong, Caroline/0000-0002-5206-5477
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NR 264
TC 58
Z9 60
U1 1
U2 25
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0013-7227
EI 1945-7170
J9 ENDOCRINOLOGY
JI Endocrinology
PD AUG
PY 2021
VL 162
IS 8
AR bqab079
DI 10.1210/endocr/bqab079
EA APR 2021
PG 20
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA TD0AE
UT WOS:000668998000002
PM 33857309
OA Bronze
DA 2025-06-11
ER

PT J
AU Fourny, N
   Lan, C
   Kober, F
   Boulghobra, D
   Bresciani, J
   Reboul, C
   Bernard, M
   Desrois, M
AF Fourny, Natacha
   Lan, Carole
   Kober, Frank
   Boulghobra, Doria
   Bresciani, Jordan
   Reboul, Cyril
   Bernard, Monique
   Desrois, Martine
TI Cardiac remodeling and higher sensitivity to ischemia-reperfusion injury
   in female rats submitted to high-fat high-sucrose diet: An in
   vivo/ex vivo longitudinal follow-up
SO JOURNAL OF NUTRITIONAL BIOCHEMISTRY
LA English
DT Article
DE Prediabetes; High-fat high-sucrose diet; Female gender; Cardiac MRI;
   Ischemia-reperfusion; Oxidative stress
ID AORTIC ENDOTHELIAL FUNCTION; INDUCED METABOLIC SYNDROME; IMPAIRED
   FASTING GLUCOSE; MYOCARDIAL BLOOD-FLOW; NITRIC-OXIDE; HIGH-CARBOHYDRATE;
   CARDIOVASCULAR-DISEASE; ABDOMINAL OBESITY; SEXUAL-DIMORPHISM; OXIDATIVE
   STRESS
AB Prediabetes is an important risk factor for Type 2 diabetes and cardiovascular complications, such as myocardial infarction. However, few studies explore female sex in this context. Here, we aim to investigate the effects of high-fat high-sucrose diet on cardiac parameters and sensitivity to ischemia-reperfusion injury of female Wistar rats. Female Wistar rats received for 5 months normal diet (CTRL group) or high-fat high-sucrose diet (HFS group). Every month, MRI was performed to follow myocardial morphology, function and perfusion; cardiac and hepatic triglyceride content; and amount of sub-cutaneous and visceral adipose tissues. Then, ex vivo experiments were performed on isolated perfused hearts to evaluate tolerance to ischemia-reperfusion, with simultaneous measurement of energy metabolism by P-31 MRS and contractile function. Coronary flow was measured before and after ischemia. At the end of the experiments, hearts were freeze-clamped for biochemical assays. Five months of high-fat high-sucrose diet induced a prediabetic condition in female Wistar rats, associated with an increase in myocardial perfusion, systolic and diastolic wall thickness. HFS rats also exhibited higher sensitivity to ischemia-reperfusion injury in comparison to controls, characterized by impaired cardiac function, energy metabolism and endothelial function. Biochemical analyses in hearts highlighted eNOS uncoupling, higher malondialdehyde level and lower S-Glutathionylation of proteins in HFS rats, indicating higher oxidative stress. Prediabetes induced by energy-dense diet was associated with modification of cardiac morphology and higher myocardial sensitivity to ischemia-reperfusion injury. These results may be related to the high risk of cardiovascular complications among Type 2 diabetic women. (C) 2019 Elsevier Inc. All rights reserved.
C1 [Fourny, Natacha; Lan, Carole; Kober, Frank; Bresciani, Jordan; Bernard, Monique; Desrois, Martine] Aix Marseille Univ, CNRS, CRMBM, Marseille, France.
   [Boulghobra, Doria; Reboul, Cyril] Univ Avignon, LaPEC EA4278, Avignon, France.
C3 Centre National de la Recherche Scientifique (CNRS); Aix-Marseille
   Universite; Avignon Universite
RP Fourny, N (corresponding author), Aix Marseille Univ, CNRS, UMR 7339, CRMBM,Fac Med, 27 Blvd Jean Moulin, F-13385 Marseille 05, France.
EM natacha.fourny@etu.univ-amu.fr; carole.lan@univ-amu.fr;
   frank.kober@univ-amu.fr; doriaboulghobra@gmail.com;
   jordan.bresciani@etu.univ-amu.fr; cyril.reboul@univ-avignon.fr;
   monique.bernard@univ-amu.fr; martine.desrois@univ-amu.fr
RI Bresciani, Jordan/AAX-9742-2020; Kober, Frank/L-8737-2013; BERNARD,
   Monique/Q-7254-2017
OI reboul, cyril/0000-0001-5181-3827; Kober, Frank/0000-0002-7869-3615;
   Bresciani, Jordan/0000-0001-5986-1807; BERNARD,
   Monique/0000-0002-3179-8698
FU Aix-Marseille Universite, CNRS [UMR 7339]; France Life Imaging
   [ANR-11-INBS-0006]; Agence Nationale de la Recherche [ANR-14-CE17-0016 -
   COFLORES]; Fondation pour la Recherche Medicate [FRM DBS20140930772]
FX This work was supported by Aix-Marseille Universite, CNRS (UMR 7339) and
   France Life Imaging (ANR-11-INBS-0006). We further acknowledge funding
   from Agence Nationale de la Recherche (ANR-14-CE17-0016 - COFLORES) and
   Fondation pour la Recherche Medicate (FRM DBS20140930772). Funding was
   not involved in study design; in collection, analysis and interpretation
   of data; in the writing of the report; and in the decision to submit the
   article for publication.
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NR 64
TC 6
Z9 7
U1 0
U2 12
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0955-2863
EI 1873-4847
J9 J NUTR BIOCHEM
JI J. Nutr. Biochem.
PD JUL
PY 2019
VL 69
BP 139
EP 150
DI 10.1016/j.jnutbio.2019.03.022
PG 12
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA IE2UJ
UT WOS:000472239600014
PM 31082660
OA Green Submitted, Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Jiang, H
   Wang, YH
   Wei, CX
   Zhang, X
   Liu, HC
   Liu, XQ
AF Jiang, Hao
   Wang, Yu-Hao
   Wei, Chun-Xiang
   Zhang, Xue
   Liu, Hao-Chen
   Liu, Xiao-Quan
TI A mini-network balance model for evaluating the progression of
   cardiovascular complications in Goto-Kakizaki rats
SO ACTA PHARMACOLOGICA SINICA
LA English
DT Article
DE diabetes; cardiovascular risk; endothelial function; oxidative stress;
   glycation; lipid profiles; modeling; metformin; salvianolic acid A;
   biomarkers; network pharmacology; Goto-Kakizaki rats
ID ENDOTHELIAL DYSFUNCTION; MULTIMARKER APPROACH; METABOLIC SYNDROME;
   OXIDATIVE STRESS; SALVIANOLIC ACID; TYPE-2; ACTIVATION; BIOMARKERS; ADMA
AB Cardiovascular complications represent a leading cause of mortality in patients with type 2 diabetes mellitus (T2DM). During such complicated progression, subtle variations in the cardiovascular risk (CVR)-related biomarkers have been used to identify cardiovascular disease at the incipient stage. In this study we attempt to integrally characterize the progression of cardiovascular complications and to assess the beneficial effects of metformin combined with salvianolic acid A (Sal A), in Goto-Kakizaki (GK) rats with spontaneous T2DM. The rats were treated with metformin (200 mg.kg(-1).d(-1), ig) alone or in combination with Sal A (1 mg.kg-1.d-1, ip) at ages from 8 to 22 weeks. During the treatment, the levels of asymmetric dimethylarginine, L-arginine, superoxide dismutase, malondialdehyde, glucose, high density lipoprotein and low density lipoprotein were assessed. Based on alterations in these biomarkers, a mini-network balance model was established using matrixes and vectors. Radar charts were created to visually depict the disruption of CVR-related modules (endothelial function, oxidative stress, glycation and lipid profiles). The description for the progression of cardiovascular disorder was quantitatively represented by u, the dynamic parameter of the model. The modeling results suggested that untreated GK rats tended to have more severe cardiovascular complications than the treatment groups. Metformin monotherapy retarded disease deterioration, whereas the combination treatment ameliorated the disease progression via restoring the balance. The current study, which focused on the balance of the mini-network and interactions among CVR-related modules, proposes a novel method for evaluating the progression of cardiovascular complications in T2DM as well as a more beneficial intervention strategy.
C1 [Jiang, Hao; Wang, Yu-Hao; Wei, Chun-Xiang; Zhang, Xue; Liu, Hao-Chen; Liu, Xiao-Quan] China Pharmaceut Univ, Ctr Drug Metab & Pharmacokinet, Nanjing 210009, Peoples R China.
C3 China Pharmaceutical University
RP Liu, XQ (corresponding author), China Pharmaceut Univ, Ctr Drug Metab & Pharmacokinet, Nanjing 210009, Peoples R China.
EM lxq@cpu.edu.cn
RI Wang, Yuhao/B-9238-2017; Liu, xiaoquan/LNP-4987-2024
FU National Natural Science Foundation of China [81273588, 81473274];
   Fundamental Research Funds for the Central Universities [ZJ15107]
FX This work was funded by the National Natural Science Foundation of China
   (No 81273588 and 81473274) and Fundamental Research Funds for the
   Central Universities (ZJ15107). The authors wish to thank Feng ZHANG
   from the Department of Pharmacology, School of Pharmacy, Nanjing
   University of Chinese Medicine and Ning LI for constructive advice and
   help revising the manuscript.
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NR 47
TC 0
Z9 0
U1 1
U2 16
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1671-4083
EI 1745-7254
J9 ACTA PHARMACOL SIN
JI Acta Pharmacol. Sin.
PD MAR
PY 2017
VL 38
IS 3
BP 362
EP 370
DI 10.1038/aps.2016.129
PG 9
WC Chemistry, Multidisciplinary; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Pharmacology & Pharmacy
GA EN1TK
UT WOS:000395792800007
PM 28042873
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Santiago, E
   Martínez, MP
   Climent, B
   Muñoz, M
   Briones, AM
   Salaices, M
   García-Sacristán, A
   Rivera, L
   Prieto, D
AF Santiago, Elvira
   Pilar Martinez, Maria
   Climent, Belen
   Munoz, Mercedes
   Maria Briones, Ana
   Salaices, Mercedes
   Garcia-Sacristan, Albino
   Rivera, Luis
   Prieto, Dolores
TI Augmented oxidative stress and preserved vasoconstriction induced by
   hydrogen peroxide in coronary arteries in obesity: role of COX-2
SO BRITISH JOURNAL OF PHARMACOLOGY
LA English
DT Article
ID VASCULAR SMOOTH-MUSCLE; ENDOTHELIAL DYSFUNCTION; CYCLOOXYGENASE-2
   EXPRESSION; NAD(P)H OXIDASE; HYPERPOLARIZING FACTOR;
   SUPEROXIDE-PRODUCTION; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   HYPERTENSIVE-RATS; CONCISE GUIDE
AB BACKGROUND AND PURPOSE
   Oxidative stress plays a key role in the vascular and metabolic abnormalities associated with obesity. Herein, we assessed whether obesity can increase coronary vasoconstriction induced by hydrogen peroxide (H2O2) and the signalling pathways involving COX-2 and superoxide (O-2(center dot-)) generation.
   EXPERIMENTAL APPROACH
   Contractile responses to H2O2 and O-2(center dot-) generation were measured in coronary arteries from genetically obese Zucker rats (OZR) and compared to lean Zucker rats (LZR).
   KEY RESULTS
   Both basal and H2O2-stimulated O-2(center dot-) production were enhanced in coronary arteries from OZR, but H2O2-induced vasoconstriction was unchanged. The selective COX-2 inhibitor NS398 significantly reduced H2O2-induced contractions in endothelium-denuded arteries from LZR and OZR, but only in endothelium-intact arteries from LZR. PGI(2) (IP) receptor antagonism modestly reduced the vasoconstrictor action of H2O2 while antagonism of the PGE2 receptor 4 (EP4) enhanced H2O2 contractions in arteries from OZR but not LZR. Basal release of COX-2-derived PGE2 was higher in coronary arteries from OZR where the selective agonist of EP4 receptors TCS 2519 evoked potent relaxations. COX-2 was up-regulated after acute exposure to H2O2 in coronary endothelium and vascular smooth muscle (VSM) and inhibition of COX-2 markedly reduced H2O2-elicited O-2(center dot-) generation in coronary arteries and myocardium. Expression of Nox subunits in VSM and NADPH-stimulated O-2(center dot-) generation was enhanced and contributed to H2O2 vasoconstriction in arteries from obese rats.
   CONCLUSION AND IMPLICATIONS
   COX-2 contributes to cardiac oxidative stress and to the endothelium-independent O-2(center dot-)-mediated coronary vasoconstriction induced by H2O2 in obesity, which is offset by the release of COX-2-derived endothelial PGE2 acting on EP4 vasodilator receptors.
C1 [Santiago, Elvira; Climent, Belen; Munoz, Mercedes; Garcia-Sacristan, Albino; Rivera, Luis; Prieto, Dolores] Univ Complutense Madrid, Fac Farm, Dept Fisiol, E-28040 Madrid, Spain.
   [Pilar Martinez, Maria] Univ Complutense Madrid, Fac Vet, Dept Anat & Anat Patol Comparadas, Madrid, Spain.
   [Maria Briones, Ana; Salaices, Mercedes] Univ Complutense Madrid, Inst Invest Hosp Univ La Paz IdiPAZ, Dept Farmacol, Fac Med, Madrid, Spain.
C3 Complutense University of Madrid; Complutense University of Madrid;
   Hospital Universitario La Paz; Complutense University of Madrid
RP Prieto, D (corresponding author), Univ Complutense Madrid, Fac Farm, Dept Fisiol, E-28040 Madrid, Spain.
EM dprieto@ucm.es
RI ; Martinez, Pilar/E-8591-2016; Rivera de los Arcos, Luis/T-2247-2018;
   Climent, Belen/P-2416-2015; PRIETO, DOLORES/S-8172-2018
OI Briones, Ana/0000-0001-8218-5579; Martinez, Pilar/0000-0001-9063-3191;
   Rivera de los Arcos, Luis/0000-0002-0187-707X; Salaices Sanchez,
   Mercedes/0000-0003-3323-1692; Climent, Belen/0000-0003-0852-9227;
   PRIETO, DOLORES/0000-0001-7049-5991; Munoz Picos,
   Mercedes/0000-0002-1679-9588
FU MINECO-Fondo Europeo de Desarrollo Regional (FEDER), Spain [SAF
   2012-31631]; Universidad Complutense de Madrid [GR3/14]; Ramon y Cajal
   Program [RYC-2010-06473]; ISCIII-FEDER [PI13/01488]
FX This work was supported by grant SAF 2012-31631 from MINECO-Fondo
   Europeo de Desarrollo Regional (FEDER), Spain and grant GR3/14 from
   Universidad Complutense de Madrid. AMB was supported by the Ramon y
   Cajal Program (RYC-2010-06473) and by grant PI13/01488 from
   ISCIII-FEDER. We thank Francisco Puente and Manuel Perales for their
   expert technical assistance.
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NR 70
TC 15
Z9 18
U1 0
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0007-1188
EI 1476-5381
J9 BRIT J PHARMACOL
JI Br. J. Pharmacol.
PD NOV
PY 2016
VL 173
IS 22
BP 3176
EP 3195
DI 10.1111/bph.13579
PG 20
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA EA6TZ
UT WOS:000386763200002
PM 27535007
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Ashida, T
   Ono, C
   Sugiyama, T
AF Ashida, Terunao
   Ono, Chikako
   Sugiyama, Takao
TI Effects of short-term hypocaloric diet on sympatho-vagal interaction
   assessed by spectral analysis of heart rate and blood pressure
   variability during stress tests in obese hypertensive patients
SO HYPERTENSION RESEARCH
LA English
DT Article
DE essential hypertension; obesity; sympatho-vagal interaction; spectral
   analysis; leptin
ID SYMPATHETIC NERVOUS-SYSTEM; METABOLIC SYNDROME; WEIGHT-REDUCTION;
   CATECHOLAMINES; MAINTENANCE; BAROREFLEX; HUMANS
AB We examined the effects of a short-term low-calorie diet on the activity of the autonomic nervous system during stress tests in obese patients with hypertension by analysis of heart rate and blood pressure variability. Eighteen obese inpatients with essential hypertension were given a regular-calorie diet (1,600 kcal, NaCl 7 g) for 4 days, and then a low-calorie diet (1,100 kcal, NaCl 7 g) for 11 days. During both the regular-calorie diet and low-calorie diet, power spectral analysis of heart rate and blood pressure variability at rest and during mental arithmetic test, deep breathing test, isometric handgrip test or cold pressor test was performed. Body weight and 24-h ambulatory blood pressure were significantly lower during the low-calorie diet than during the regular-calorie diet. Systolic and diastolic blood pressure significantly increased over the handgrip test and cold pressor test during both diets. The low frequency component (LF) of systolic blood pressure, a marker of sympathetic activity to the vasculature, during the deep breathing test and cold pressor test were significantly lower on the low-calorie diet than the regular-calorie diet. The blood leptin concentration was also significantly lower on the low-calorie diet than the regular-calorie diet. The decrease in body weight was positively correlated with the decrease in blood leptin concentration. The LF/high frequency component (HF) ratio of the RR interval at rest on the regular-calorie diet was negatively correlated with the decrease in blood leptin concentration. These results suggest that the autonomic nervous function assessed by analysis of heart rate and blood pressure variability during stress tests may be improved by weight loss due to a short-term low-calorie diet in obese patients with hypertension.
C1 [Ashida, Terunao; Ono, Chikako; Sugiyama, Takao] Asahi Life Fdn, Inst Adult Dis, Chiyoda Ku, Div Cardiovasc Dis, Tokyo 1000005, Japan.
C3 Asahi Life Foundation
RP Ashida, T (corresponding author), Asahi Life Fdn, Inst Adult Dis, Chiyoda Ku, Div Cardiovasc Dis, 1-6-1 Marunouchi, Tokyo 1000005, Japan.
EM ashidat@asahi-life.or.jp
CR ANDERSSON B, 1991, HYPERTENSION, V18, P783, DOI 10.1161/01.HYP.18.6.783
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NR 18
TC 24
Z9 27
U1 0
U2 8
PU JAPANESE SOC HYPERTENSION CENT ACADEMIC SOC, PUBL OFFICE
PI TOYONAKA
PA SENRI ASAHI HANKYU BLDG, 13TH FLOOR, 1-5-3 SHINSENRIHIGASHI-MACHI,
   TOYONAKA, 560-0082, JAPAN
SN 0916-9636
J9 HYPERTENS RES
JI Hypertens. Res.
PD DEC
PY 2007
VL 30
IS 12
BP 1199
EP 1203
DI 10.1291/hypres.30.1199
PG 5
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 272XM
UT WOS:000253895000008
PM 18344625
OA Bronze
DA 2025-06-11
ER

PT J
AU Noma, K
   Goto, C
   Nishioka, K
   Jitsuiki, D
   Umemura, T
   Ueda, K
   Kimura, M
   Nakagawa, K
   Oshima, T
   Chayama, K
   Yoshizumi, M
   Liao, JK
   Higashi, Y
AF Noma, Kensuke
   Goto, Chikara
   Nishioka, Kenji
   Jitsuiki, Daisuke
   Umemura, Takashi
   Ueda, Keiko
   Kimura, Masashi
   Nakagawa, Keigo
   Oshima, Tetsuya
   Chayama, Kazuaki
   Yoshizumi, Masao
   Liao, James K.
   Higashi, Yukihito
TI Roles of Rho-associated kinase and oxidative stress in the pathogenesis
   of aortic stiffness
SO JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
LA English
DT Article
ID NITRIC-OXIDE SYNTHASE; SMOOTH-MUSCLE-CELLS; STAGE RENAL-DISEASE;
   ENDOTHELIAL DYSFUNCTION; PROTEIN-KINASE; METABOLIC SYNDROME;
   HYPERTENSION; INHIBITION; ARTERIES; HUMANS
AB Objectives The purpose of this study was to determine the relationship between Rho-associated kinase (ROCK) activity and aortic stiffness in humans.
   Background Epidemiologic studies have shown that there is a relationship between aortic stiffness and cardiovascular complications. Recent evidence suggests that ROCK plays an important role in the process of atherosclerosis.
   Methods We evaluated the forearm blood flow (FBF) response to sodium nitroprusside (SNP), a nitric oxide donor, acetylcholine (ACh), an endothelium-dependent vasodilator, and fasudil, a specific ROCK inhibitor, in 51 healthy male subjects (mean age 45.6 +/- 3.0 years). The FBF was measured by using a strain-gauge plethysmography. Carotid-femoral pulse wave velocity (cf-PWV) was measured to assess the aortic stiffness using a pulse wave velocimeter.
   Results Intra-arterial infusion of SNP alone, ACh alone, or fasudil alone and after co-infusion of N-G-Monomethyl-L-arginine (L-NMMA), a nitric-oxide synthase inhibitor, significantly increased FBF in a dose-dependent manner (p < 0.01). Multivariate analysis showed that age and number of pack-years smoked were independent predictors of ROCK activity before or after co-infusion of L-NMMA (p < 0.01) and that age and ROCK activity before or after co-infusion of L-NMMA were independent predictors of cf-PWV (p < 0.01). The concentration of serum malondialdehyde-modified low-density lipoprotein, an index of oxidative stress, was significantly correlated with ROCK activity before and after co-infusion of L-NMMA and cf-PWV (p < 0.01).
   Conclusions These findings suggest that aging and accumulating smoking habit, which might induce excessive oxidative stress, are involved in ROCK activity in the vasculature, leading to an increase in aortic stiffness in humans.
C1 Hiroshima Univ, Grad Sch Biomed Sci, Dept Cardiovasc Physiol & Med, Minami Ku, Hiroshima 7348551, Japan.
   Hiroshima Univ, Grad Sch Biomed Sci, Dept Med & Mol Sci, Hiroshima 7348551, Japan.
   Hiroshima Univ, Grad Sch Biomed Sci, Dept Clin Lab Med, Hiroshima 7348551, Japan.
   Brigham & Womens Hosp, Vasc Med Res Unit, Boston, MA 02115 USA.
   Harvard Univ, Sch Med, Boston, MA 02115 USA.
C3 Hiroshima University; Hiroshima University; Hiroshima University;
   Harvard University; Harvard University Medical Affiliates; Brigham &
   Women's Hospital; Harvard University; Harvard Medical School
RP Higashi, Y (corresponding author), Hiroshima Univ, Grad Sch Biomed Sci, Dept Cardiovasc Physiol & Med, Minami Ku, 1-2-3 Kasumi, Hiroshima 7348551, Japan.
EM yhigashi@hiroshima-u.ac.jp
RI Higashi, Yukihito/G-5343-2019; Chayama, Kazuaki/B-2493-2016
OI Chayama, Kazuaki/0000-0002-5530-5341
FU NHLBI NIH HHS [R01 HL052233, R01 HL070274, R01 HL080187] Funding Source:
   Medline; NIDDK NIH HHS [R01 DK062729] Funding Source: Medline
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NR 39
TC 85
Z9 95
U1 0
U2 3
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0735-1097
EI 1558-3597
J9 J AM COLL CARDIOL
JI J. Am. Coll. Cardiol.
PD FEB 13
PY 2007
VL 49
IS 6
BP 698
EP 705
DI 10.1016/j.jacc.2006.06.082
PG 8
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 137TO
UT WOS:000244315300009
PM 17291936
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Palachai, N
   Wattanathorn, J
   Muchimapura, S
   Thukham-mee, W
AF Palachai, Nut
   Wattanathorn, Jintanaporn
   Muchimapura, Supaporn
   Thukham-mee, Wipawee
TI Antimetabolic Syndrome Effect of Phytosome Containing the Combined
   Extracts of Mulberry and Ginger in an Animal Model of Metabolic Syndrome
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Article
ID ANTIOXIDANT ACTIVITIES; INSULIN-RESISTANCE; PPAR-GAMMA; OBESITY;
   CHOLESTEROL; VALIDATION; ASSAY; FAT; PATHOPHYSIOLOGY; LIGAND
AB Due to the antimetabolic syndrome effect of mulberry and ginger together with the advantages of the synergistic effect and phytosome encapsulation technique, we hypothesized that phytosome containing the combined extracts of mulberry and ginger (PMG) should be able to manage MetS. PMG was developed and assessed the phenolic content and biological activities associated with the pathophysiology of MetS. The antimetabolic syndrome effect and the possible underlying mechanisms in the animal model of MetS were also assessed. Male Wistar rats induced MetS by subjecting to a 16-week high-carbohydrate high-fat diet. MetS rats were orally given PMG at doses of 50, 100, and 200 mg/kg for 21 days. They were determined metabolic parameter changes in serum, histomorphology changes of adipose tissue, the inflammatory cytokines such as IL-6 and TNF-alpha, oxidative stress status, PPAR-gamma, and HDAC3 in adipose tissue. Our in vitro data showed that PMG increased phenolic contents and biological activities. PMG significantly improved MetS parameters including body weight gain, lipid profiles, plasma glucose, HOMA-IR, and ACE. In addition, the density and size of adipocyte, adiposity index, and weights of adipose tissues were also improved. Moreover, the decrease in TNF-alpha and IL-6, oxidative stress status, and HDAC3 expression together with the increase in PPAR-gamma expression in adipose tissue was also observed. These data suggest that PMG exhibit antimetabolic syndrome and the possible underlying mechanism may be associated partly with the modulation effect on HDAC3, PPAR-gamma, and adipose tissue. In addition, PMG also improves oxidative stress and inflammation in MetS. Therefore, PMG can be served as the potential supplement to manage MetS. However, a clinical trial study is essential to confirm this health benefit.
C1 [Palachai, Nut; Wattanathorn, Jintanaporn; Muchimapura, Supaporn; Thukham-mee, Wipawee] Khon Kaen Univ, Fac Med, Dept Physiol, Khon Kaen 40002, Thailand.
   [Palachai, Nut] Khon Kaen Univ, Fac Med, Neurosci Program, Grad Sch, Khon Kaen 40002, Thailand.
   [Palachai, Nut; Wattanathorn, Jintanaporn; Muchimapura, Supaporn; Thukham-mee, Wipawee] Khon Kaen Univ, Integrat Complementary Alternat Med Res, Khon Kaen 40002, Thailand.
   [Palachai, Nut; Wattanathorn, Jintanaporn; Muchimapura, Supaporn; Thukham-mee, Wipawee] Khon Kaen Univ, Res Inst Human High Performance & Hlth Promot, Khon Kaen 40002, Thailand.
C3 Khon Kaen University; Khon Kaen University; Khon Kaen University; Khon
   Kaen University
RP Wattanathorn, J (corresponding author), Khon Kaen Univ, Fac Med, Dept Physiol, Khon Kaen 40002, Thailand.; Wattanathorn, J (corresponding author), Khon Kaen Univ, Integrat Complementary Alternat Med Res, Khon Kaen 40002, Thailand.; Wattanathorn, J (corresponding author), Khon Kaen Univ, Res Inst Human High Performance & Hlth Promot, Khon Kaen 40002, Thailand.
EM jinwat05@gmail.com
RI Palachai, Nut/HKM-6781-2023
OI Muchimapura, Supaporn/0000-0001-7756-1955; Palachai,
   Nut/0000-0002-9672-9941; Wattanathorn, Jintanaporn/0000-0002-7383-2348
FU Royal Golden Jubilee (RGJ) Ph.D., Thailand Research Fund (TRF)
   [PHD/0181/2558]; Integrative Complementary Alternative Medicine Research
   and Development Center in Research Institute of Human High Performance
   and Health Promotion, Khon Kaen University, Khon Kaen, Thailand
FX This study was supported by the Royal Golden Jubilee (RGJ) Ph.D. which
   is a part of Thailand Research Fund (TRF) (Research No. PHD/0181/2558)
   and Integrative Complementary Alternative Medicine Research and
   Development Center in Research Institute of Human High Performance and
   Health Promotion, Khon Kaen University, Khon Kaen, Thailand.
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NR 50
TC 25
Z9 25
U1 1
U2 13
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PD NOV 11
PY 2019
VL 2019
AR 5972575
DI 10.1155/2019/5972575
PG 19
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA JQ8AO
UT WOS:000499161600005
PM 31827683
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Queisser, N
   Happ, K
   Link, S
   Jahn, D
   Zimnol, A
   Geier, A
   Schupp, N
AF Queisser, Nina
   Happ, Kathrin
   Link, Samuel
   Jahn, Daniel
   Zimnol, Anna
   Geier, Andreas
   Schupp, Nicole
TI Aldosterone induces fibrosis, oxidative stress and DNA damage in livers
   of male rats independent of blood pressure changes
SO TOXICOLOGY AND APPLIED PHARMACOLOGY
LA English
DT Article
DE Hyperaldosteronism; Mineralocorticoid receptor; DNA damage; alpha-SMA;
   gamma-H2AX; Nrf2
ID MINERALOCORTICOID RECEPTOR ANTAGONIST; CHRONIC HEPATITIS-C; BILE-DUCT
   LIGATION; HEPATOCELLULAR-CARCINOMA; METABOLIC SYNDROME; ANGIOTENSIN-II;
   STRAND BREAKS; NADPH OXIDASE; GLUTATHIONE; CANCER
AB Mineralocorticoid receptor blockers show antifibrotic potential in hepatic fibrosis. The mechanism of this protective effect is not known yet, although reactive oxygen species seem to play an important role. Here, we investigated the effects of elevated levels of aldosterone (Ald), the primary ligand of the mineralocorticoid receptor, on livers of rats in a hyperaldosteronism model: aldosterone-induced hypertension.
   Male Sprague-Dawley rats were treated for 4 weeks with aldosterone. To distinguish if damage caused in the liver depended on increased blood pressure or on increased Ald levels, the mineralocorticoid receptor antagonist spironolactone was given in a subtherapeutic dose, not normalizing blood pressure. To investigate the impact of oxidative stress, the antioxidant tempol was administered.
   Aldosterone induced fibrosis, detected histopathologically, and by expression analysis of the fibrosis marker, alpha-smooth muscle actin. Further, the mRNA amount of the profibrotic cytokine TGF-beta was increased significantly. Fibrosis could be reduced by scavenging reactive oxygen species, and also by blocking the mineralocorticoid receptor. Furthermore, aldosterone treatment caused oxidative stress and DNA double strand breaks in livers, as well as the elevation of DNA repair activity. An increase of the transcription factor Nrf2, the main regulator of the antioxidative response could be observed, and of its target genes heme oxygenase-1 and gamma-glutamylcysteine synthetase. All these effects of aldosterone were prevented by spironolactone and tempol.
   Already after 4 weeks of treatment, aldosteroneinfusion induced fibrosis in the liver. This effect was independent of elevated blood pressure. DNA damage caused by aldosterone might contribute to fibrosis progression when aldosterone is chronically increased. (C) 2014 Elsevier Inc. All rights reserved.
C1 [Queisser, Nina; Happ, Kathrin; Link, Samuel; Zimnol, Anna; Schupp, Nicole] Univ Wurzburg, Inst Pharmacol & Toxicol, Versbacher Str 9, D-97078 Wurzburg, Germany.
   [Jahn, Daniel; Geier, Andreas] Univ Hosp Wurzburg, Dept Med 2, Div Hepatol, Wurzburg, Germany.
C3 University of Wurzburg; University of Wurzburg
RP Schupp, N (corresponding author), Univ Wurzburg, Inst Pharmacol & Toxicol, Versbacher Str 9, D-97078 Wurzburg, Germany.
EM schupp@uni-duesseldorf.de
OI Schupp, Nicole/0000-0002-1836-6348
FU German Research Foundation (Deutsche Forschungsgemeinschaft) [Schu
   2367/1-2]; German Cancer Aid (Deutsche Krebshilfe) [109328]
FX We would like to thank Prof. Justus Muller, Institute of Pathology,
   University of Wiirzburg, for pathological examinations and helpful
   discussions. This work was supported by the German Research Foundation
   (Deutsche Forschungsgemeinschaft: grant Schu 2367/1-2 to N.S.) and by
   the German Cancer Aid (Deutsche Krebshilfe: grant #109328 to N.S.).
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NR 47
TC 27
Z9 28
U1 0
U2 17
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0041-008X
EI 1096-0333
J9 TOXICOL APPL PHARM
JI Toxicol. Appl. Pharmacol.
PD NOV 1
PY 2014
VL 280
IS 3
BP 399
EP 407
DI 10.1016/j.taap.2014.08.029
PG 9
WC Pharmacology & Pharmacy; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Toxicology
GA AT5JU
UT WOS:000344980400002
PM 25204689
DA 2025-06-11
ER

PT J
AU Lima, AAM
   Anstead, GM
   Zhang, Q
   Figueiredo, IL
   Soares, AM
   Mota, RMS
   Lima, NL
   Guerrant, RL
   Oriáa, RB
AF Lima, Aldo A. M.
   Anstead, Gregory M.
   Zhang, Qiong
   Figueiredo, Italo L.
   Soares, Alberto M.
   Mota, Rosa M. S.
   Lima, Noelia L.
   Guerrant, Richard L.
   Oria, Reinaldo B.
TI Effects of glutamine alone or in combination with zinc and vitamin A on
   growth, intestinal barrier function, stress and satiety-related hormones
   in Brazilian shantytown children
SO CLINICS
LA English
DT Article
DE Micronutrients; Stress; Growth and Development; Intestinal Barrier
   Function; Hormonal Biomarkers
ID METABOLIC SYNDROME; IMMUNE-RESPONSE; LEPTIN; ADIPONECTIN; MALNUTRITION;
   ENERGY; IGF-1; CHILDHOOD; GHRELIN; INSULIN
AB OBJECTIVE: To determine the impact of supplemental zinc, vitamin A, and glutamine alone or in combination on growth, intestinal barrier function, stress and satiety-related hormones among Brazilian shantytown children with low median height-for-age z-scores.
   METHODS: A randomized, double-blind, placebo-controlled trial was conducted in children aged two months to nine years from the urban shanty compound community of Fortaleza, Brazil. Demographic and anthropometric information was assessed. The random treatment groups available for testing (a total of 120 children) were as follows: (1) glutamine alone, n = 38; (2) glutamine plus vitamin A plus zinc, n = 37; and a placebo (zinc plus vitamin A vehicle) plus glycine (isonitrogenous to glutamine) control treatment, n = 38. Leptin, adiponectin, insulin-like growth factor (IGF-1), and plasma levels of cortisol were measured with immune-enzymatic assays; urinary lactulose/mannitol and serum amino acids were measured with high-performance liquid chromatography. ClinicalTrials.gov: NCT00133406.
   RESULTS: Glutamine treatment significantly improved weight-for-height z-scores compared to the placeboglycine control treatment. Either glutamine alone or all nutrients combined prevented disruption of the intestinal barrier function, as measured by the percentage of lactulose urinary excretion and the lactulose: mannitol absorption ratio. Plasma leptin was negatively correlated with plasma glutamine (p = 0.002) and arginine (p = 0.001) levels at baseline. After glutamine treatment, leptin was correlated with weight-for-age (WAZ) and weight-for-height z-scores (WHZ) (p <= 0.002) at a 4-month follow-up. In addition, glutamine and all combined nutrients (glutamine, vitamin A, and zinc) improved the intestinal barrier function in these children.
   CONCLUSION: Taken together, these findings reveal the benefits of glutamine alone or in combination with other gut-trophic nutrients in growing children via interactions with leptin.
C1 [Lima, Aldo A. M.; Figueiredo, Italo L.; Soares, Alberto M.; Mota, Rosa M. S.; Lima, Noelia L.; Guerrant, Richard L.; Oria, Reinaldo B.] Univ Fed Ceara, Sch Med, Clin Res Unit, Fortaleza, CE, Brazil.
   [Lima, Aldo A. M.; Figueiredo, Italo L.; Soares, Alberto M.; Mota, Rosa M. S.; Lima, Noelia L.; Guerrant, Richard L.; Oria, Reinaldo B.] Ctr Global Hlth, Inst Biomed, Dept Physiol & Pharmacol, Fortaleza, CE, Brazil.
   [Zhang, Qiong; Guerrant, Richard L.] Univ Virginia, Sch Med, Ctr Global Hlth, Div Infect Dis, Charlottesville, VA 22908 USA.
   [Anstead, Gregory M.] South Texas Vet Hosp, San Antonio, TX USA.
C3 Universidade Federal do Ceara; University of Virginia
RP Lima, AAM (corresponding author), Univ Fed Ceara, Sch Med, Clin Res Unit, Fortaleza, CE, Brazil.
EM oria@ufc.br
RI Oria, Reinaldo/D-6440-2014; Anstead, Gregory/AAV-3255-2020; LIMA,
   ALDO/D-8251-2018
OI LIMA, ALDO/0000-0002-0299-1747; Oria, Reinaldo/0000-0002-6914-5481;
   Soares, Alberto Melo/0000-0002-3359-6109
FU Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq);
   International Collaborations in Infectious Disease Research (ICIDR)
   program of the US NIH [5 U01 AI026512]
FX The Brazilian funding agency Conselho Nacional de Desenvolvimento
   Cientifico e Tecnologico (CNPq) and the International Collaborations in
   Infectious Disease Research (ICIDR) program of the US NIH (Grant # 5 U01
   AI026512) supported this study.
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NR 36
TC 22
Z9 25
U1 1
U2 15
PU HOSPITAL CLINICAS, UNIV SAO PAULO
PI SAO PAULO
PA FAC MEDICINA, UNIV SAO PAULO, SAO PAULO, SP 00000, BRAZIL
SN 1807-5932
EI 1980-5322
J9 CLINICS
JI Clinics
PY 2014
VL 69
IS 4
BP 225
EP 233
DI 10.6061/clinics/2014(04)02
PG 9
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA AF3HL
UT WOS:000334602400002
PM 24714829
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Kurata, T
   Miyazaki, K
   Morimoto, N
   Kawai, H
   Ohta, Y
   Ikeda, Y
   Abe, K
AF Kurata, Tomoko
   Miyazaki, Kazunori
   Morimoto, Nobutoshi
   Kawai, Hiromi
   Ohta, Yasuyuki
   Ikeda, Yoshio
   Abe, Koji
TI Atorvastatin and pitavastatin reduce oxidative stress and improve
   IR/LDL-R signals in Alzheimer's disease
SO NEUROLOGICAL RESEARCH
LA English
DT Article
DE Alzheimer's disease; Atorvastatin; Insulin receptor; LDL receptor;
   Pitavastatin
ID TRANSGENIC MOUSE MODEL; APOLIPOPROTEIN E-DEFICIENT; AMYLOID
   PLAQUE-FORMATION; GLYCATION END-PRODUCTS; A-BETA; INSULIN-RESISTANCE;
   LIPID-PEROXIDATION; METABOLIC SYNDROME; IN-VITRO; DIABETIC-PATIENTS
AB Objectives: To examine and compare the pleiotropic effects on oxidative stress and metabolic signaling pathways of atorvastatin and pitavastatin in mouse model of Alzheimer's disease (AD).
   Methods: We gave the transgenic (Tg) mice either atorvastatin or pitavastatin from 5-20 months (M) of age, and performed immunohistological analysis [4-hydroxy-2-nonenal (4-HNE)-positive, advanced glycation end products (AGEs), low-density lipoprotein receptor (LDL-R)-positive neurons, apolipoprotein E (ApoE)-positive senile plaque (SP), and insulin receptor (IR)-positive endothelium], and biochemistry analysis (adiponectin and leptin).
   Results: The numbers of 4-HNE- and AGE-positive neurons and the sum of ApoE-positive SP size progressively increased with age in amyloid precursor protein (APP)-Tg mice, while the amount of IR-positive endothelium and the number of LDL-R-positive neurons decreased. Adiponectin and leptin serum levels were lower in APP-Tg mice than in non-Tg mice. Treatment with statins reduced the number of AGE-positive neurons from as early as 10 M, preserved the numbers of 4-HNE-and LDL-R-positive neurons and the amount of IR-positive endothelium at 15 M, and reduced the sum of ApoE-positive SP size and adiponectin serum level at 20 M.
   Discussion: Atorvastatin and pitavastatin reduced the level of oxidative stress, as revealed by the presence of 4-HNE and AGE, in AD mouse brains, and that treatment with statins improves insulin signaling and LDLR/ApoE systems. The beneficial effects of these statins may be associated with direct pleiotropic effects on AD mouse brains, indirect effects through improving the serum adiponectin/leptin balance, or both.
C1 [Kurata, Tomoko; Miyazaki, Kazunori; Morimoto, Nobutoshi; Kawai, Hiromi; Ohta, Yasuyuki; Ikeda, Yoshio; Abe, Koji] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Neurol, Okayama 7008558, Japan.
C3 Okayama University
RP Abe, K (corresponding author), Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Neurol, Kita Ku, 2-5-1 Shikatacho, Okayama 7008558, Japan.
EM toko11@cc.okayama-u.ac.jp
FU Ministry of Education, Culture, Sports, Science and Technology of Japan;
   Research Committee of CNS Degenerative Diseases; Ministry of Health,
   Labour and Welfare of Japan;  [21390267]
FX This work was partly supported by a Grant-in-Aid for Scientific Research
   (B) 21390267 and the Ministry of Education, Culture, Sports, Science and
   Technology of Japan, and by Grants-in-Aid from the Research Committee of
   CNS Degenerative Diseases (I. Nakano), and grants (M. Nishizawa and H.
   Mizusawa) from the Ministry of Health, Labour and Welfare of Japan.
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NR 70
TC 36
Z9 40
U1 0
U2 9
PU MANEY PUBLISHING
PI LEEDS
PA STE 1C, JOSEPHS WELL, HANOVER WALK, LEEDS LS3 1AB, W YORKS, ENGLAND
SN 0161-6412
J9 NEUROL RES
JI Neurol. Res.
PD MAR
PY 2013
VL 35
IS 2
BP 193
EP 205
DI 10.1179/1743132812Y.0000000127
PG 13
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 101KL
UT WOS:000315773800017
PM 23336815
DA 2025-06-11
ER

PT J
AU Mochizuki, K
   Misaki, Y
   Miyauchi, R
   Takabe, S
   Shimada, M
   Miyoshi, N
   Ichikawa, Y
   Goda, T
AF Mochizuki, Kazuki
   Misaki, Yasumi
   Miyauchi, Rie
   Takabe, Satsuki
   Shimada, Masaya
   Miyoshi, Noriyuki
   Ichikawa, Yoko
   Goda, Toshinao
TI Circulating interleukin-1β and interleukin-6 concentrations are closely
   associated with γ-glutamyltranspeptidase activity in middle-aged
   Japanese men without obvious cardiovascular diseases
SO METABOLISM-CLINICAL AND EXPERIMENTAL
LA English
DT Article
ID TYPE-2 DIABETES-MELLITUS; NF-KAPPA-B; OXIDATIVE STRESS;
   INSULIN-RESISTANCE; ALANINE AMINOTRANSFERASE; METABOLIC SYNDROME; REDOX
   REGULATION; ADIPOSE-TISSUE; SERUM-LEVELS; WEIGHT-LOSS
AB Interleukin (IL)-1 beta and IL-6 expressions are known to be induced by oxidant stress. In the present study, we examined the relationships between these interleukins and the activity of gamma-glutamyltranspeptidase (gamma-GTP), which was recently reported as a source of oxidant stress production, in the circulating blood of middle-aged Japanese men without obvious cardiovascular diseases. We conducted a cross-sectional study of 317 Japanese men without obvious cardiovascular diseases aged 40 to 69 years (mean SD, 58.6 +/- 7.6 years) who participated in health checkups in Japan. We analyzed their clinical parameters in serum, lifestyle factors, and plasma IL-1 beta and IL-6 concentrations. We compared the relationships between these interleukin concentrations and the clinical parameters and lifestyle factors by Spearman correlation coefficients. Stepwise multiple linear regression analyses for interleukins based on the other parameters and gamma-GTP, which were classified into 3 groups according to the concentrations, were performed. Interleukin-1 beta and IL-6 concentrations were closely associated with gamma-GTP activity but less associated with alanine aminotransferase and aspartate aminotransferase activities by Spearman correlation coefficients. Stepwise multiple linear regression analyses showed that gamma-GTP activity was the explanatory variable for elevated IL-1 beta and IL-6 concentrations. As natural logarithms, the IL-1 beta and IL-6 concentrations were estimated to be 1.734- and 1.157-fold higher, respectively, in subjects with high gamma-GTP activity ranges than in subjects with a low gamma-GTP activity range. The present results show that circulating IL-1 beta and IL-6 concentrations are strongly and independently associated with gamma-GTP activity in middle-aged Japanese men without obvious cardiovascular diseases. (C) 2011 Elsevier Inc. All rights reserved.
C1 [Goda, Toshinao] Univ Shizuoka, Sch Food & Nutr Sci, Lab Nutr Physiol, Grad Sch Nutr & Environm Sci, Shizuoka 4228526, Japan.
   [Mochizuki, Kazuki; Misaki, Yasumi; Miyauchi, Rie; Takabe, Satsuki; Shimada, Masaya; Goda, Toshinao] Univ Shizuoka, Grad Sch Nutr & Environm Sci, Global COE Program, Shizuoka 4228526, Japan.
   [Miyoshi, Noriyuki] Univ Shizuoka, Grad Sch Nutr & Environm Sci, Biochem Lab, Shizuoka 4228526, Japan.
   [Ichikawa, Yoko] Univ Shizuoka, Grad Sch Nutr & Environm Sci, Lab Food Management, Shizuoka 4228526, Japan.
C3 University of Shizuoka; University of Shizuoka; University of Shizuoka;
   University of Shizuoka
RP Goda, T (corresponding author), Univ Shizuoka, Sch Food & Nutr Sci, Lab Nutr Physiol, Grad Sch Nutr & Environm Sci, 52-1 Yada, Shizuoka 4228526, Japan.
EM gouda@u-shizuoka-ken.ac.jp
RI Miyoshi, Noriyuki/F-4554-2010; Goda, Toshinao/C-8981-2014
OI Miyoshi, Noriyuki/0000-0002-4233-4282
FU Ministry of Education, Science, Sports, and Culture of Japan; Ministry
   of Health, Labour, and Welfare of Japan
FX This study was financially supported by the Global COE Program for the
   Center of Excellence for Innovation in Human Health Sciences from the
   Ministry of Education, Science, Sports, and Culture of Japan, and a
   grant from the Ministry of Health, Labour, and Welfare of Japan.
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NR 41
TC 5
Z9 5
U1 0
U2 0
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0026-0495
J9 METABOLISM
JI Metab.-Clin. Exp.
PD JUL
PY 2011
VL 60
IS 7
BP 914
EP 922
DI 10.1016/j.metabol.2010.08.011
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 786XC
UT WOS:000292340200003
PM 20934730
DA 2025-06-11
ER

PT J
AU Liao, YL
   Takashima, S
   Zhao, H
   Asano, Y
   Shintani, Y
   Minamino, T
   Kim, J
   Fujita, M
   Hori, M
   Kitakaze, M
AF Liao, YL
   Takashima, S
   Zhao, H
   Asano, Y
   Shintani, Y
   Minamino, T
   Kim, J
   Fujita, M
   Hori, M
   Kitakaze, M
TI Control of plasma glucose with alpha-glucosidase inhibitor attenuates
   oxidative stress and slows the progression of heart failure in mice
SO CARDIOVASCULAR RESEARCH
LA English
DT Article
DE glucose metabolism; myocardial hypertrophy; oxidative stress; heart
   failure
ID LEFT-VENTRICULAR HYPERTROPHY; PRESSURE-OVERLOAD MODEL; FATTY-ACID
   OXIDATION; CARDIAC-HYPERTROPHY; NADPH OXIDASE; MYOCARDIAL-INFARCTION;
   MECHANICAL EFFICIENCY; CARDIOVASCULAR EVENTS; INSULIN SENSITIVITY;
   METABOLIC SYNDROME
AB Objective: It has been suggested that reduction in glucose levels contributes to the prolongation of life span of rodents in conjunction with restricted food intake, and hyperglycemia has been confirmed as a risk factor for cardiovascular disease (CVD), raising the possibility that better glycemic control could slow the progression of CVD. This study was designed to determine whether impaired glucose tolerance develops during the progression of cardiac hypertrophy and heart failure, and whether tight glycemic control could reduce the severity of heart failure.
   Methods: In male C57BL/6 mice, transverse aortic constriction (TAC) was employed to create cardiac hypertrophy and heart failure. The involvement of NADPH in TAC mice and cardiac myocytes in the neonatal rat was investigated.
   Results: The random-fed plasma glucose concentration was higher in TAC mice, and it was reduced to about 100 mg/dL by voglibose (an alpha-glycosidase inhibitor). Four weeks after TAC, both the heart weight/body weight ratio and the lung weight/body weight ratio were lower in the voglibose group than in the TAC group. Echocardiographic and invasive hemodynamic examination showed improvement of left ventricular function in voglibose-treated mice. Voglibose treatment decreased the myocardial expression of an NADPH oxidase subunit (p47(phox)). Glucose dose-dependently increased both neonatal rat myocyte protein synthesis and the expression of p47(phox) protein, while apocynin (an NADPH oxidase inhibitor) blocked the enhancement of protein synthesis by high glucose.
   Conclusion: Improvement of glycemic control through voglibose therapy inhibited cardiac remodeling by decreasing myocardial oxidative stress in mice with cardiac pressure overload. (c) 2006 European Society of Cardiology. Published by Elsevier B.V. All rights reserved.
C1 Natl Cardiovasc Ctr, Div Cardiovasc, Dept Med, Suita, Osaka 5658565, Japan.
   Osaka Univ, Grad Sch Med, Dept Cardiovasc Med, Suita, Osaka 5650871, Japan.
C3 National Cerebral & Cardiovascular Center - Japan; The University of
   Osaka
RP Natl Cardiovasc Ctr, Div Cardiovasc, Dept Med, 5-7-1 Fujishirodai, Suita, Osaka 5658565, Japan.
EM kitakaze@zf6.so-net.ne.jp
RI Liao, Yulin/AAP-6315-2021
OI Shintani, Yasunori/0000-0001-9579-0727; Liao, yulin/0000-0001-5961-390X
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NR 55
TC 40
Z9 51
U1 0
U2 2
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0008-6363
EI 1755-3245
J9 CARDIOVASC RES
JI Cardiovasc. Res.
PD APR 1
PY 2006
VL 70
IS 1
BP 107
EP 116
DI 10.1016/j.cardiores.2006.01.021
PG 10
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 034NA
UT WOS:000236934500015
PM 16510136
DA 2025-06-11
ER

PT J
AU Iftikhar, N
   Hussain, AI
   Kamal, GM
   Manzoor, S
   Fatima, T
   Alswailmi, FK
   Ahmad, A
   Alsuwayt, B
   Alnasser, SMA
AF Iftikhar, Neelam
   Hussain, Abdullah Ijaz
   Kamal, Ghulam Mustafa
   Manzoor, Sidra
   Fatima, Tabinda
   Alswailmi, Farhan Khashim
   Ahmad, Ashfaq
   Alsuwayt, Bader
   Abdullah Alnasser, Sulaiman Mohammed
TI Antioxidant, Anti-Obesity, and Hypolipidemic Effects of Polyphenol Rich
   Star Anise (Illicium verum) Tea in High-Fat-Sugar Diet-Induced
   Obesity Rat Model
SO ANTIOXIDANTS
LA English
DT Article
DE BMI; VLDL; HDL; kidney index; liver index; high-fat diet; DPPH radical
   scavenging activity; phenolic acids and flavonoids
ID SERUM BILIRUBIN LEVELS; ZINGIBER-OFFICINALE; METABOLIC SYNDROME;
   EXTRACT; PROFILE; LIPASE; L.
AB Star anise (Illicium verum Hook. fil.) is commonly utilized as a culinary and medicinal fruit and is most famous in indigenous systems of medicine. The present research work aims to appraise and validate the potential of polyphenol-rich star anise tea (SAT) on oxidative stress, obesity and related biochemical parameters in high-fat-sugar-diet (HFSD)-induced obesity model in rats. SAT was prepared using the traditional method in warm water. The Reverse Phase High Pressure Liquid Chromatography (RP-HPLC) analysis was performed for the simultaneous determination of phenolic acids and flavonoids in SAT. Two doses (250 and 500 mg/kg body weight) were selected to investigate the anti-obesity potential of SAT using HFSD-induced obese rat model. Major (>5 mg/100 mL) phenolic acids in SAT were p-coumeric acid, gallic aid, cinamic acid, chlorogenic acid and ferulic acid while catechin and rutin were the major flavonoids detected in the SAT. SAT exhibited 51.3% DPPH radical scavenging activity. In vivo study showed that higher doses of SAT (500 mg/kg body weight) significantly reduced the body weight increase (74.82%) and BMI (0.64 g/cm(2)). Moreover, significant reductions in the levels of serum total cholesterol, triglyceride, LDL and VLDL were recorded in all the treatment groups in comparison to the HFSDC group. Furthermore, SAT reduced the alterations in MDA, SOD and GSH levels of experimental groups thus showing the potential against oxidative stress. The SAT-500 group showed a significant decrease in the elevated kidney and liver weights and atherogenic index in comparison to the HFSDC group. The present study proved that SAT exhibited strong protective effects against obesity and oxidative stress, especially at higher doses.
C1 [Iftikhar, Neelam; Hussain, Abdullah Ijaz; Manzoor, Sidra] Govt Coll Univ Faisalabad, Dept Chem, Nat Prod & Synthet Chem NPSC Lab, Faisalabad 38000, Pakistan.
   [Hussain, Abdullah Ijaz] Govt Coll Univ Faisalabad, Cent Hitech Lab, Faisalabad 38000, Pakistan.
   [Kamal, Ghulam Mustafa] Khwaja Fareed Univ Engn & Informat Technol, Inst Chem, Rahim Yar Khan 64200, Pakistan.
   [Fatima, Tabinda] Univ Hafr Al Batin, Coll Pharm, Dept Pharmaceut Chem, Hafar al Batin 39524, Saudi Arabia.
   [Alswailmi, Farhan Khashim; Ahmad, Ashfaq; Alsuwayt, Bader] Univ Hafr Al Batin, Coll Pharm, Dept Pharm Practice, Hafar al Batin 39524, Saudi Arabia.
   [Abdullah Alnasser, Sulaiman Mohammed] Qassim Univ, Unaizah Coll Pharm, Dept Pharmacol & Toxicol, Buraydah 51452, Saudi Arabia.
C3 Government College University Faisalabad; Government College University
   Faisalabad; Khwaja Fareed University of Engineering & Information
   Technology, Pakistan; Hafr Albatin University; Hafr Albatin University;
   Qassim University
RP Hussain, AI (corresponding author), Govt Coll Univ Faisalabad, Dept Chem, Nat Prod & Synthet Chem NPSC Lab, Faisalabad 38000, Pakistan.; Hussain, AI (corresponding author), Govt Coll Univ Faisalabad, Cent Hitech Lab, Faisalabad 38000, Pakistan.; Alnasser, SMA (corresponding author), Qassim Univ, Unaizah Coll Pharm, Dept Pharmacol & Toxicol, Buraydah 51452, Saudi Arabia.
EM abdullahijaz@gcuf.edu.pk; sm.alnasser@qu.edu.sa
RI ALSWAILMI, FARHAN/ABM-1370-2022; Hussain, Abdullah/AGI-0192-2022; Ahmad,
   Ashfaq/IUM-8419-2023; Alsuwayt, Bader/HSG-7114-2023; Kamal,
   Ghulam/AAP-2325-2021
OI Hussain, Abdullah Ijaz/0000-0001-7862-8859; Alnasser,
   Sulaiman/0000-0001-8678-5029; Ahmad, Ashfaq/0000-0002-9185-4639; Kamal,
   Ghulam Mustafa/0000-0003-1323-2364
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NR 46
TC 18
Z9 18
U1 1
U2 33
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD NOV
PY 2022
VL 11
IS 11
AR 2240
DI 10.3390/antiox11112240
PG 15
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA 8U0PB
UT WOS:000929652300001
PM 36421427
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Qin, S
   Huang, LF
   Gong, JJ
   Shen, SS
   Huang, J
   Tang, Y
   Ren, H
   Hu, HD
AF Qin, Si
   Huang, Lifan
   Gong, Jiaojiao
   Shen, Shasha
   Huang, Juan
   Tang, Yao
   Ren, Hong
   Hu, Huaidong
TI Meta-analysis of randomized controlled trials of 4 weeks or longer
   suggest that curcumin may afford some protection against oxidative
   stress
SO NUTRITION RESEARCH
LA English
DT Review
DE Curcumin; Oxidative stress; Malondialdehyde; Superoxide dismutase;
   Glutathione peroxidase; Meta-analysis
ID TYPE-2 DIABETES-MELLITUS; QUALITY-OF-LIFE; ANTIOXIDANT MECHANISM;
   PIPERINE COMBINATION; MALONDIALDEHYDE MDA; BIOLOGICAL SAMPLES; METABOLIC
   SYNDROME; SULFUR MUSTARD; INJURY; SERUM
AB Oxidative stress (OS) is associated with aging and multiple diseases, yet the effects of curcumin in humans are not definite. We undertook a meta-analysis of the effects of curcumin on OS biomarkers. In January 2018, we searched PubMed, Books@Ovid, Joumals@Ovid, EMBASE, MEDLINE(R), and Web of Science to identify randomized controlled trials conducted >= 4 weeks and investigating the effects of curcumin on OS biomarkers, including glutathione peroxidase (GPX) activity in red blood cells (RBC), serum malondialdehyde (MDA) concentrations, and superoxide dismutase (SOD) activity. The standardized mean difference (SMD) with a 95% confidence interval (CI) was used to present the results. The meta-analysis included eight clinical studies (626 patients). There was a significant reduction in circulating MDA concentrations (SMD = -0.769, 95% CI: -1.059 to -0.478) and a significant increase in SOD activity (SMD = 1.084, 95% CI: 0.487 to 1.680) following curcumin supplementation. There was no change in the GPX activity in RBC. There was no significant association between the MDA-lowering effect of curcumin with underlying diseases or treatment duration. However, curcumin showed the MDA-lowering effect at curcuminoids doses >600 mg/d (P < .0001). This effect was greater when combined with piperine than curcuminoids alone (SMD = -1.085, 95% CI: -1.357 to -0.813; SMD = -0.850, 95% CI: -1.158 to -0.542). Curcumin may play an anti-oxidative role by reducing circulating MDA concentrations and increasing SOD activity. Further research of curcumin in different populations with multiple biomarkers of redox status is required. (C) 2018 Elsevier Inc. All rights reserved.
C1 [Qin, Si] Chongqing Med Univ, Affiliated Hosp 3, Gener Hosp, Ctr Endocrine Dis, Chongqing, Peoples R China.
   [Qin, Si; Huang, Lifan; Gong, Jiaojiao; Shen, Shasha; Huang, Juan; Tang, Yao; Hu, Huaidong] Chongqing Med Univ, Affiliated Hosp 2, Dept Clin Nutr, 76 Linjiang Rd, Chongqing 400010, Peoples R China.
   [Gong, Jiaojiao; Shen, Shasha; Huang, Juan; Tang, Yao; Ren, Hong; Hu, Huaidong] Chongqing Med Univ, Affiliated Hosp 2, Inst Viral Hepatitis,Dept Infect Dis, Key Lab Mol Biol Infect Dis,Minist Educ, Chongqing, Peoples R China.
C3 Chongqing Medical University; Chongqing Medical University; Ministry of
   Education - China; Chongqing Medical University
RP Hu, HD (corresponding author), Chongqing Med Univ, Affiliated Hosp 2, Dept Clin Nutr, 76 Linjiang Rd, Chongqing 400010, Peoples R China.
EM qinsi315@163.com; huanglifan10@163.com; gongjiaojiaogo@163.com;
   shashashensss@163.com; huangjuan_108@163.com; ty542610@126.com;
   renhong0531@vip.sina.com; huhuaidong@sina.com
RI qin, si/JCO-3256-2023
OI qin, si/0000-0002-0863-9699
FU National Natural Science Foundation of China [81171560]; "Par-Eu
   Scholars Program" of Chongqing City; National Science and Technology
   Major Project of China [2012ZX10002007001]
FX This work was supported by the National Natural Science Foundation of
   China [No. 81171560], the "Par-Eu Scholars Program" of Chongqing City
   and the National Science and Technology Major Project of China [No.
   2012ZX10002007001]. The funding bodies had no role in study design, data
   collection and analysis, decision to publish, or the preparation of the
   manuscript. The authors declare that they have no competing interests.
   The author contributions are as follows: SQ HR, and HDH contributed to
   the conception and design of the study. SQ LFH, and HDH conducted the
   literature search and data extraction. LFH and SQ performed the
   statistical analyses. SQ LFH, JJG, SSS, JH, YT, and HDH drafted the
   manuscript. HR and HDH supervised the study. All authors gave final
   approval of this manuscript.
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NR 69
TC 37
Z9 41
U1 1
U2 18
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0271-5317
EI 1879-0739
J9 NUTR RES
JI Nutr. Res.
PD DEC
PY 2018
VL 60
BP 1
EP 12
DI 10.1016/j.nutres.2018.08.003
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA HF4ER
UT WOS:000454186500001
PM 30527253
DA 2025-06-11
ER

PT J
AU Xu, MX
   Zhu, YF
   Chang, HF
   Liang, Y
AF Xu, Min-Xuan
   Zhu, Yan-Fang
   Chang, Hsiao-Feng
   Liang, Ying
TI Nanoceria restrains PM2.5-induced metabolic disorder and hypothalamus
   inflammation by inhibition of astrocytes activation related NF-κB
   pathway in Nrf2 deficient mice
SO FREE RADICAL BIOLOGY AND MEDICINE
LA English
DT Article
DE Particulate matter 2.5; Nanoceria; Neuroinflammation; NF-kappa B; Nrf2
ID CERIUM OXIDE NANOPARTICLES; CENTRAL-NERVOUS-SYSTEM; INDUCED OXIDATIVE
   STRESS; AIR-POLLUTION EXPOSURE; PARTICULATE MATTER;
   CARDIOVASCULAR-DISEASE; MICROGLIA; MECHANISMS; OBESITY; CELLS
AB Increasing studies demonstrated that air pollution (PM2.5) plays a significant role in metabolic and neurological diseases. Unfortunately, there is no direct testimony of this, and yet the molecular mechanism by which the occurrence remains unclear. In this regard, we investigated the role of NF-kappa B and Nrf2 signaling in PM2.5-induced metabolic disorders and neuroinflammation, and further confirmed whether Nrf2 deficiency promoted PM2.5-induced inflammatory response by up regulating astrocytes activation and nerve injury via modulating NF-kappa B signaling pathways. Present results found that, indeed, PM2.5 challenges results in glucose tolerance, insulin resistance, dysarteriotony, peripheral inflammation, nerve injury and hypothalamus oxidative stress through astrocytes activation related NF-kappa B pathway in Nrf2 deficient mice. Moreover, in vitro study, we confirmed that activated astrocytes induced by PM2.5 were involved in pathogenesis of hypothalamic inflammation, which were significantly associated with NF-kappa B signaling. Nanoceria as potential anti-inflammatory and anti-oxidant stress biomaterial has gained increasing attention. Moderate nanoceria treatment is able to restrain PM2.5-induced metabolic syndrome and inflammation. Inhibition of astrocytes activation related NF-kappa B and enhancement of Nrf2 by cerium oxide were observed in vivo and in vitro, suggesting cerium oxide inhibited hypothalamic inflammation and nerve injury by altering hypothalamic neuroendocrine alterations and decreasing glial cells activation. In addition, NF-kappa B inhibitor pyrollidine dithiocarbamate (PDTC) treated primary astrocytes directly determined Nrf2 pathway could be up regulated by dose-dependent nanoceria. These results suggest a new therapeutic approach or target to protect against air pollution related diseases by cerium oxide treatment. (C) 2016 Elsevier Inc. All rights reserved.
C1 [Liang, Ying] Changzhou Univ, Res Inst Leisure Ind, Changzhou 213164, Peoples R China.
   [Xu, Min-Xuan; Zhu, Yan-Fang; Chang, Hsiao-Feng] Fenchem Ingredient Technol Co, Nanjing 210023, Jiangsu, Peoples R China.
   [Xu, Min-Xuan; Zhu, Yan-Fang; Chang, Hsiao-Feng] Nanjing Univ, Nanjing 210023, Jiangsu, Peoples R China.
C3 Changzhou University; Nanjing University
RP Liang, Y (corresponding author), Changzhou Univ, Res Inst Leisure Ind, Changzhou 213164, Peoples R China.
EM bolucy79@163.com
OI Xu, Minxuan/0000-0002-0742-4717
FU School-Enterprise Cooperation project of Changzhou University
FX This work was funded by School-Enterprise Cooperation project of
   Changzhou University.
CR [Anonymous], MICROVASC RES
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NR 49
TC 99
Z9 109
U1 0
U2 62
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0891-5849
EI 1873-4596
J9 FREE RADICAL BIO MED
JI Free Radic. Biol. Med.
PD OCT
PY 2016
VL 99
BP 259
EP 272
DI 10.1016/j.freeradbiomed.2016.08.021
PG 14
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA EC3AD
UT WOS:000387995400025
PM 27554971
DA 2025-06-11
ER

PT J
AU Bloedon, LT
   Balikai, S
   Chittams, J
   Cunnane, SC
   Berlin, JA
   Rader, DJ
   Szapary, PO
AF Bloedon, LeAnne T.
   Balikai, Shilpa
   Chittams, Jesse
   Cunnane, Stephen C.
   Berlin, Jesse A.
   Rader, Daniel J.
   Szapary, Philippe O.
TI Flaxseed and cardiovascular risk factors: Results from a double blind,
   randomized, controlled clinical trial
SO JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION
LA English
DT Article
DE flaxseed; hypercholesterolemia; lipoproteins; insulin resistance;
   inflammation; oxidative stress
ID ALPHA-LINOLENIC ACID; CORONARY-HEART-DISEASE; C-REACTIVE PROTEIN;
   SERUM-LIPIDS; INSULIN SENSITIVITY; DIETARY-SUPPLEMENT; METABOLIC
   SYNDROME; LDL-CHOLESTEROL; FATTY-ACIDS; ENTEROLACTONE
AB Objective: Flaxseed is a rich source of alpha linolenic acid (ALA), fiber and lignans, making it a potentially attractive functional food for modulating cardiovascular risk. We studied the effects of flaxseed on markers of cardiovascular risk in hypercholesterolemic adults.
   Methods: Sixty-two men and post-menopausal women with pre-study low density lipoprotein cholesterol (LDL-C) between 130 and 200 mg/dl were randomized to 40g/day of ground flaxseed-containing baked products or matching wheat bran products for 10 weeks while following a low fat, low cholesterol diet. Fasting lipoproteins, measures of insulin resistance, inflammation, oxidative stress, and safety were assessed at 0, 5 and 10 weeks.
   Results: Flaxseed was well-tolerated, and increased serum levels of ALA (p < 0.001). Compared to wheat, flaxseed significantly reduced LDL-C at 5 weeks (-13%, p < 0.005), but not at 10 weeks (-7%, p = 0.07). Flaxseed reduced lipoprotein a (Lp[a]) by a net of 14% (p = 0.02), and reduced the homeostatic model assessment of insulin resistance (HOMA-IR) index by 23.7% (p = 0.03) compared to wheat at 10 weeks, but did not affect markers of inflammation (IL-6, Hs-CRP) or oxidative stress (ox LDL, urinary isoprostanes) at any time points. In men, flaxseed reduced HDL-C concentrations by a net of 16% (p = 0.03) and 9% (p = 0.05) at 5 and 10 weeks, respectively.
   Conclusions: Ground flaxseed has a modest but short lived LDL-C lowering effect, yet reduces Lp(a) and improves insulin sensitivity in hyperlipidemic adults. The HDL-C lowering effect of flaxseed in men warrants additional study.
C1 [Bloedon, LeAnne T.; Szapary, Philippe O.] Univ Penn, Sch Med, Gen Clin Res Ctr, Div Gen Internal Med, Philadelphia, PA 19104 USA.
   [Bloedon, LeAnne T.; Rader, Daniel J.; Szapary, Philippe O.] Univ Penn, Sch Med, Gen Clin Res Ctr, Inst Translat Med & Therapeut, Philadelphia, PA 19104 USA.
   [Chittams, Jesse; Berlin, Jesse A.; Szapary, Philippe O.] Univ Penn, Sch Med, Gen Clin Res Ctr, Ctr Clin Epidemiol & Biostat, Philadelphia, PA 19104 USA.
   [Cunnane, Stephen C.] Univ Sherbrooke, Res Ctr Aging, Sherbrooke, PQ J1K 2R1, Canada.
C3 University of Pennsylvania; University of Pennsylvania; University of
   Pennsylvania; University of Sherbrooke
RP Szapary, PO (corresponding author), Univ Penn Hlth Syst, Philadelphia Heart Inst, Cardiovasc Risk Intervent Program, 39th & Market St, Philadelphia, PA 19104 USA.
EM philippe.szapary@uphs.upenn.edu
RI Rader, Daniel/AFQ-9696-2022
OI Balikai, Shilpa/0000-0003-0979-7151
FU NCCIH NIH HHS [K-23 AT-00058, R21AT01291] Funding Source: Medline; NCRR
   NIH HHS [M01-RR00040] Funding Source: Medline
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NR 33
TC 176
Z9 200
U1 0
U2 32
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 0731-5724
EI 1541-1087
J9 J AM COLL NUTR
JI J. Am. Coll. Nutr.
PD FEB
PY 2008
VL 27
IS 1
BP 65
EP 74
DI 10.1080/07315724.2008.10719676
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 292VT
UT WOS:000255294900009
PM 18460483
DA 2025-06-11
ER

PT J
AU Davies, MG
   Saad, WE
AF Davies, Mark G.
   Saad, Wael E.
TI Impact of Elevated Perioperative Fasting Blood Glucose on Carotid Artery
   Stenting Outcomes
SO ANNALS OF VASCULAR SURGERY
LA English
DT Article
ID FOCAL CEREBRAL-ISCHEMIA; MYOCARDIAL-INFARCTION; INTRACEREBRAL
   HEMORRHAGE; STRESS HYPERGLYCEMIA; INCREASED RISK; STROKE; ADMISSION;
   LEVEL; MODULATION; INCREASES
AB Background: Carotid artery stenting (CAS) for high-risk individuals is accepted practice. An impaired fasting hyperglycemia (IFG) is often associated with poor procedural outcomes after other percutaneous procedures. The clinical outcomes of CAS for patients with elevated fasting blood sugar (FBS) are not well defined.
   Methods: A database of patients undergoing CAS was sampled from 2000 to 2009. An IFG was defined as plasma glucose >110 mg/dL. Life table analyses were performed to assess time-dependent outcome differences between those patients with and without IFG. The outcomes of freedom from restenosis, occlusion, death, recurrent symptoms, and neurologic event were calculated. Cox proportional hazard analysis or Fisher's exact test was performed to identify factors associated with outcomes.
   Results: During the study period 322 patients underwent 345 CAS procedures. The mean follow-up was 4.6 years. A total of 196 patients (61%) were male. The indications for CAS were neurologic symptoms in high-risk patients in 23% and asymptomatic high-risk in the remainder. Fifty-nine percent had an IFG but only 30% had a history of diabetes mellitus (DM). Patients with an IFG were more likely to suffer a major adverse event (MAE; death, myocardial infarction, stroke; 12% vs. 26%, <= 110 vs. >110, respectively, at 5 years, P = 0.021 by chi-squared analysis) in the 90-day perioperative period. By life table analysis, there were no differences between normal and IFG patients with regards to freedom from occlusion or target vessel revascularization. The long-term MAE rate was significantly worse in patients with an IFG, driven by decreased survival and stroke rates. Patients carrying the diagnosis of DM had equivalent outcomes to non-DM patients (67 +/- 5% vs. 62 +/- 7%, <= 110 vs. >110, respectively, at 5 years, P = 0.84). The presence of metabolic syndrome and/or the combination of diabetes and metabolic syndrome in the IFG group were drivers of increasing poor MAE rates.
   Conclusions: Patients with IFG undergoing CAS are at a greater risk for periprocedural morbidity and worse MAE in both the short and long term. The diagnosis of DM does not have a similar impact on outcomes. A current IFG, as opposed to a history of DM, should be considered an important risk factor when determining the suitability for CAS.
C1 [Davies, Mark G.; Saad, Wael E.] Houston Methodist Hosp, Dept Cardiovasc Surg, Houston Methodist DeBakey Heart & Vasc Ctr, Houston, TX 77030 USA.
C3 Houston Methodist
RP Davies, MG (corresponding author), Houston Methodist Hosp, Dept Cardiovasc Surg, Houston Methodist DeBakey Heart & Vasc Ctr, 6550 Fannin,Smith Tower,Suite 1401, Houston, TX 77030 USA.
EM MDavies@tmhs.org
RI Davies, Mark/IUQ-1315-2023
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NR 29
TC 8
Z9 8
U1 0
U2 3
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0890-5096
EI 1615-5947
J9 ANN VASC SURG
JI Ann. Vasc. Surg.
PD NOV
PY 2014
VL 28
IS 8
BP 1885
EP 1891
DI 10.1016/j.avsg.2014.07.001
PG 7
WC Surgery; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery; Cardiovascular System & Cardiology
GA AS8EZ
UT WOS:000344484100013
PM 25011085
DA 2025-06-11
ER

PT J
AU Joubert, MBV
   Degrave, V
   Ingaramo, P
   Oliva, ME
   D'Alessandro, ME
AF Vega Joubert, Michelle Berenice
   Degrave, Valentina
   Ingaramo, Paola
   Eugenia Oliva, Maria
   Eugenia D'Alessandro, Maria
TI Salvia hispanica L. (chia) seed improves liver inflammation and
   endothelial dysfunction in an experimental model of metabolic syndrome
SO FOOD & FUNCTION
LA English
DT Article
ID OXIDATIVE STRESS; BIOACTIVE PEPTIDES; INSULIN-RESISTANCE; ACID;
   FIBROSIS; OBESITY
AB The purposes of the present study were to analyze liver inflammation and endothelial dysfunction in an experimental model of metabolic syndrome (MS) induced by chronic administration of a sucrose-rich diet (SRD) and to evaluate the effects of chia seed as a therapeutic strategy. Male Wistar rats were fed with a reference diet (RD) for 6 months or a SRD for 3 months. Then, the latter group was randomly divided into two subgroups. One subgroup continued receiving the SRD for up to 6 months and the other was fed with a SRD where whole chia seed was incorporated as a source of dietary fat for the next 3 months (SRD + CHIA). Results showed that rats fed a SRD for a long period of time developed dyslipidemia, hyperglycemia, inflammation and endothelial dysfunction. Hepatic NAS, IL-1 beta, NF kappa B p65, PAI-1, and F4-80 expression, as well as MPO activity were significantly increased and IL-10 expression was significantly decreased; this was accompanied by increased plasma IL-6 and TNF-alpha levels in rats fed a SRD. In addition, serum and liver nitric oxide (NO) levels and nitric oxide synthase (NOS) were significantly increased in the SRD group. In addition, a significant increase in hepatic iNOS expression and a positive correlation of this with liver NF kappa B p65 was found. We observed a significant increase in hepatic intercellular adhesion molecule (ICAM), and a negative correlation of this with liver Nrf2 was found. The administration of chia seed for 3 months reversed dyslipidemia, hyperglycemia, inflammation and endothelial dysfunction. In the liver tissue, NAS, IL-1 beta, IL-10, NF kappa B p65, PAI-1, and F4-80 expression and MPO activity were normalized. Serum and liver NO and NOS levels and hepatic iNOS expression were decreased and this last one was associated with a decrease in liver NF kappa B p65 levels. Hepatic ICAM-1 was normalized and negatively correlated with liver NrF2 levels. This study showed new aspects of liver inflammation and endothelial dysfunction in dyslipidemic insulin resistant rats chronically fed with a sucrose-rich diet. In addition, we demonstrated new properties and molecular mechanisms associated with beneficial effects on inflammation and endothelial dysfunction of chia seed as a therapeutic strategy.
C1 [Vega Joubert, Michelle Berenice; Degrave, Valentina; Eugenia Oliva, Maria; Eugenia D'Alessandro, Maria] Univ Nacl Litoral, Fac Bioquim & Ciencias Biol, Lab Estudio Enfermedades Metab Relacionadas Nutr, CONICET, Ciudad Univ,Cc242, RA-3000 Santa Fe, Argentina.
   [Ingaramo, Paola] Consejo Nacl Invest Cient & Tecn, Inst Salud & Ambiente Litoral ISAL, Fac Bioquim & Cs Biol, Santa Fe, Argentina.
C3 Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET);
   National University of the Littoral; Consejo Nacional de Investigaciones
   Cientificas y Tecnicas (CONICET)
RP Oliva, ME; D'Alessandro, ME (corresponding author), Univ Nacl Litoral, Fac Bioquim & Ciencias Biol, Lab Estudio Enfermedades Metab Relacionadas Nutr, CONICET, Ciudad Univ,Cc242, RA-3000 Santa Fe, Argentina.
EM meoliva@fbcb.unl.edu.ar
RI Oliva, Maria/IUM-4089-2023
OI Oliva, Maria Eugenia/0000-0002-4368-4102; D' Alessandro, Maria
   Eugenia/0000-0001-6008-5614
FU Fondo para la Investigacion Cientifica y Tecnologica, Argentina;
   Universidad Nacional del Litoral, Argentina [CAI + D]
   [50620190100008LI]; Grant PICT [2018-01344]; Forte [2018-01344] Funding
   Source: Forte
FX This work was supported by Fondo para la Investigacion Cientifica y
   Tecnologica, Argentina. Grant PICT #2018-01344 and Universidad Nacional
   del Litoral, Argentina [CAI + D #50620190100008LI]. The authors would
   like to thank Silvia Rodriguez for her skillful technical assistance.
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NR 60
TC 10
Z9 10
U1 0
U2 9
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PD OCT 31
PY 2022
VL 13
IS 21
BP 11249
EP 11261
DI 10.1039/d2fo02216h
EA SEP 2022
PG 13
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA 5V3IK
UT WOS:000866143600001
PM 36222595
DA 2025-06-11
ER

PT J
AU White, CM
   Pasupuleti, V
   Roman, YM
   Li, YZ
   Hernandez, AV
AF White, C. Michael
   Pasupuleti, Vinay
   Roman, Yuani M.
   Li, Yangzhou
   Hernandez, Adrian V.
TI Oral turmeric/curcumin effects on inflammatory markers in chronic
   inflammatory diseases: A systematic review and meta-analysis of
   randomized controlled trials
SO PHARMACOLOGICAL RESEARCH
LA English
DT Review
DE Turmeric; Curcumin; Inflammation; Biomarkers; C-reactive protein
ID C-REACTIVE PROTEIN; DOUBLE-BLIND; METABOLIC SYNDROME; OXIDATIVE STRESS;
   CURCUMIN; PLACEBO; SUPPLEMENTATION; ARTHRITIS; EFFICACY; SYMPTOMS
AB Turmeric extract or active component curcumin may have anti-inflammatory effects in people with chronic inflammatory diseases. The effect of turmeric or curcumin on a wide range of inflammatory markers has not been evaluated in a systematic review. We performed a systematic review of randomized controlled trials (RCTs) evaluating the effects of oral turmeric or curcumin on inflammatory markers (CRP, hsCRP, IL-1, IL-6, TNF) in patients with a wide range of chronic inflammatory diseases. Pubmed, EMBASE, Scopus, the Web of Science, and the Cochrane library were evaluated until June 2018. Random effects meta-analyses with inverse variance methods and stratified by turmeric or curcumin were performed. Effects were expressed as mean differences (MD) and their 95% confidence intervals (CI). Risk of bias of RCTs was evaluated with the Cochrane tool. Nineteen RCTs were identified; included patients had rheumatic diseases, advanced chronic kidney disease with hemodialysis, metabolic syndrome, and cardiovascular diseases. Turmeric was the intervention in 5 RCTs (n = 356) and curcumin/curcuminoids in 14 RCTs (n = 988). Follow up times ranged between 4 and 16 weeks. One RCT had high risk of bias. In comparison to controls, turmeric or curcumin did not significantly decrease levels of CRP (MD-2.71 mg/L, 95%CI-5.73 to 0.31, p = 0.08, 5 studies), hsCRP (MD-1.44 mg/L, 95%CI-2.94 to 0.06, p = 0.06, 6 studies), IL-1 beta (MD-4.25 pg/mL, 95%CI-13.32 to 4.82, p = 0.36, 2 studies), IL-6 (MD -0.71 pg/mL, 95%CI-1.68 to 0.25, p = 0.15), and TNF alpha (MD-1.23 pg/mL, 95%CI-3.01 to 0.55, p = 0.18, 7 studies). There were no differences between turmeric and curcumin interventions. High heterogeneity of effects was observed for all markers across studies, except hsCRP. Other inflammatory markers such as IL-1 alpha, TNF beta, IL-17, and IL-22 had scarce data. Turmeric or curcumin did not decrease several inflammatory markers in patients with chronic inflammatory diseases.
C1 [White, C. Michael; Roman, Yuani M.; Li, Yangzhou; Hernandez, Adrian V.] Univ Connecticut, Sch Pharm, Hlth Outcomes Policy & Evidence Synth HOPES Grp, 69 North Eagleville Rd,U-3092, Storrs, CT 06269 USA.
   [Pasupuleti, Vinay] Pro Ed Commun Inc, Cleveland, OH USA.
   [Hernandez, Adrian V.] Univ Peruana Ciencias Aplicadas UPC, Sch Med, Lima, Peru.
C3 University of Connecticut; Universidad Peruana de Ciencias Aplicadas
   (UPC)
RP Hernandez, AV (corresponding author), Univ Connecticut, Sch Pharm, Hlth Outcomes Policy & Evidence Synth HOPES Grp, 69 North Eagleville Rd,U-3092, Storrs, CT 06269 USA.
EM adrian.hernandez-diaz@uconn.edu
RI Pasupuleti, Vinay/G-1316-2013; Hernandez, Adrian/ABD-4616-2021
OI Hernandez, Adrian V./0000-0002-9999-4003
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NR 40
TC 87
Z9 89
U1 1
U2 36
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 1043-6618
EI 1096-1186
J9 PHARMACOL RES
JI Pharmacol. Res.
PD AUG
PY 2019
VL 146
AR 104280
DI 10.1016/j.phrs.2019.104280
PG 7
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA IS6FS
UT WOS:000482248300023
PM 31121255
DA 2025-06-11
ER

PT J
AU Razliqi, RN
   Ahangarpour, A
   Mard, SA
   Khorsandi, L
AF Razliqi, Reza Noei
   Ahangarpour, Akram
   Mard, Seyyed Ali
   Khorsandi, Layasadat
TI Gentisic acid ameliorates type 2 diabetes induced by
   Nicotinamide-Streptozotocin in male mice by attenuating pancreatic
   oxidative stress and inflammation through modulation of Nrf2 and NF-kB
   pathways
SO LIFE SCIENCES
LA English
DT Article
DE Gentisic acid; Inflammation; Nrf2 pathway; Oxidative stress; Type 2
   diabetes mellitus
ID INSULIN-RESISTANCE; METABOLIC SYNDROME; BETA-CELLS; EXPRESSION; GLUCOSE;
   ACTIVATION; MECHANISM; METFORMIN; ISLETS; IL-1-BETA
AB Aims: There is a close link between oxidative stress, inflammation, and type 2 diabetes mellitus (T2DM). Gentisic acid (GA) is a di-phenolic compound and an active metabolite of aspirin that possesses antioxidant and anti-inflammatory properties, but its potential anti-diabetic effects have not been evaluated so far. Therefore, this study aimed to evaluate GA's potential antidiabetic effects through the Nuclear Factor Erythroid 2-Related Factor (Nrf2) and Nuclear Factor Kappa Beta (NF-kB) signaling pathways.Material and methods: In this study, T2DM induced by a single intraperitoneal injection of STZ (65 mg/kg B.W) after 15 min nicotinamide (120 mg/kg B.W) injection. After seven days of injections, fasting blood glucose (FBS) was measured. Seven days after FBS monitoring treatments started. Grouping and treatments were as follows: 1) Normal control group; NC, 2) Diabetic control group; DC, 3) Metformin group; MT (150 mg/kg B.W, daily), 4) Test group; GA (100 mg/kg B.W, daily). Treatments continued for 14 consecutive days.Key findings: Diabetic mice treatment with GA significantly decreased FBS, improved plasma lipid profiles and pancreatic antioxidant status. GA modulated Nrf2 pathway by upregulation of Nrf2 protein, NAD(P)H: quinone oxidoreductase 1 (Nqo1), and p21, and downregulation of miR-200a, Kelch-like ECH-associated protein 1 (Keap1), and nicotinamide adenine dinucleotide phosphate oxidase-2 (NOX2). Also, GA attenuated inflammation by upregulation of metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) and interleukin-10 (IL-10) and downregulation of miR-125b, NF-kB, tumor necrosis factor-alpha (TNF-alpha), and interleukin-1 beta (IL-1ss). Significance: GA attenuates T2DM, possibly by improving antioxidant status through the Nrf2 pathway and attenuation of inflammation.
C1 [Razliqi, Reza Noei] Ahvaz Jundishapur Univ Med Sci, Student Res Comm, Ahvaz, Iran.
   [Ahangarpour, Akram] Ahvaz Jundishapur Univ Med Sci, Med Basic Sci Res Inst, Persian Gulf Physiol Res Ctr, Dept Physiol, Ahvaz, Iran.
   [Mard, Seyyed Ali] Ahvaz Jundishapur Univ Med Sci, Physiol Res Ctr, Alimentary Tract Res Ctr, Dept Physiol,Sch Med, Ahvaz, Iran.
   [Khorsandi, Layasadat] Ahvaz Jundishapur Univ Med Sci, Med Basic Sci Res Inst, Cellular & Mol Res Ctr, Dept Anat Sci,Sch Med, Ahvaz, Iran.
C3 Ahvaz Jundishapur University of Medical Sciences (AJUMS); Ahvaz
   Jundishapur University of Medical Sciences (AJUMS); Ahvaz Jundishapur
   University of Medical Sciences (AJUMS); Ahvaz Jundishapur University of
   Medical Sciences (AJUMS)
RP Ahangarpour, A (corresponding author), Ahvaz Jundishapur Univ Med Sci, Med Basic Sci Res Inst, Persian Gulf Physiol Res Ctr, Dept Physiol, Ahvaz, Iran.
EM noei.r@ajums.ac.ir; akramahangarpour@gmail.com; mard-sa@ajums.ac.ir;
   khorsandi-l@ajums.ac.ir
RI Mard, Seyed/ABF-5973-2020; Khorsandi, Layasadat/R-3901-2017;
   Ahangarpour, Akram/I-7638-2017
OI Khorsandi, Layasadat/0000-0002-3391-3055; Noei Razliqi,
   Reza/0000-0002-4249-0322; Ahangarpour, Akram/0000-0002-9534-9699
FU Persian Gulf Physi- ology Research Center of Ahvaz Jundishapur
   University of Medical Sciences [APRC-0010]
FX This paper is a part of the Ph.D. thesis of Mr. Reza Noei Razliqi. This
   work is financially (APRC-0010) supported by the Persian Gulf Physi-
   ology Research Center of Ahvaz Jundishapur University of Medical
   Sciences.
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NR 59
TC 15
Z9 15
U1 2
U2 11
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0024-3205
EI 1879-0631
J9 LIFE SCI
JI Life Sci.
PD JUL 15
PY 2023
VL 325
AR 121770
DI 10.1016/j.lfs.2023.121770
EA MAY 2023
PG 13
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA I0BE6
UT WOS:000999505400001
PM 37192699
DA 2025-06-11
ER

PT J
AU Ikonomidis, I
   Katogiannis, K
   Chania, C
   Iakovis, N
   Tsoumani, M
   Christodoulou, A
   Brinia, E
   Pavlidis, G
   Thymis, J
   Tsilivarakis, D
   Kountouri, A
   Korakas, E
   Lambadiari, V
   Triposkiadis, F
   Skaltsounis, L
   Tseti, I
   Iliodromitis, EK
   Andreadou, I
AF Ikonomidis, Ignatios
   Katogiannis, Konstantinos
   Chania, Christina
   Iakovis, Nikolaos
   Tsoumani, Maria
   Christodoulou, Andriana
   Brinia, Evangelia
   Pavlidis, George
   Thymis, John
   Tsilivarakis, Damianos
   Kountouri, Aikaterini
   Korakas, Emmanouil
   Lambadiari, Vaia
   Triposkiadis, Filippos
   Skaltsounis, Leandros
   Tseti, Ioulia
   Iliodromitis, Efstathios K. K.
   Andreadou, Ioanna
TI Association of hydroxytyrosol enriched olive oil with vascular function
   in chronic coronary disease
SO EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
LA English
DT Article
DE coronary flow reserve; endothelial function; flow-mediated dilation;
   Hydroxytyrosol; oxidative stress; pulse wave velocity
ID INDUCED METABOLIC SYNDROME; ENDOTHELIAL FUNCTION; OXIDATIVE STRESS; FLOW
   RESERVE; ECHOCARDIOGRAPHY; OLEUROPEIN; RATS; BIOAVAILABILITY;
   CARDIOTOXICITY; CONSTITUENT
AB Background: Hydroxytyrosol reduces low-density lipoprotein oxidation, contributing to prevention of atherosclerosis progression.
   Methods: In a prospective, crossover, double-blind, placebo-controlled trial, 30 chronic coronary artery syndrome (CCAS) patients were randomized to 4 capsules/day, containing 412.5 mg olive oil with 2.5 mg hydroxytyrosol (OOHT) each one or placebo for 1 month and then were crossed over to the alternate treatment (placebo or OOHT). We measured (a) perfused boundary region (PBR) of the sublingual arterial microvessels (increased PBR indicates reduced glycocalyx thickness), (b) flow-mediated dilation (FMD), (c) Coronary Flow Reserve (CFR) and markers of LV diastolic function by Doppler echocardiography, (d) pulse wave velocity (PWV), and (e) oxidative stress, inflammatory biomarkers and blood lipids at baseline and after treatment.
   Results: Treatment with OOHT improved PBR, FMD, CFR and PWV compared to baseline (1.8 +/- .3 vs. 1.7 +/- .4 mu m, p = .040, 3.7 +/- 2.1 vs. 6.5% +/- 2.3%, p < .001, 2.3 +/- .4 vs. 2.5 +/- .4, p = .030 and 11.1 +/- 1.8 vs. 11.8 +/- 2.3 m/s, p = .002) while there was no effect after placebo (p = NS). No effect of OOHT treatment was observed on blood pressure. There was a parallel improvement of E' of the mitral annulus and deceleration time of the E wave of mitral inflow after OOHT (p < .05) but not after placebo. Compared to baseline, treatment with OOHT reduced malondialdehyde, a marker of lipid peroxidation, oxidized LDL, triglycerides, PCSK9 and CRP blood levels (p < .05) in contrast to placebo.
   Conclusions: Hydroxytyrosol-enriched olive oil may have beneficial effects on endothelial, arterial and LV diastolic function likely by reducing oxidative and inflammatory burden in CCAS, though further studies are needed to confirm this mechanism.
C1 [Ikonomidis, Ignatios; Katogiannis, Konstantinos; Pavlidis, George; Thymis, John; Tsilivarakis, Damianos; Iliodromitis, Efstathios K. K.] Natl & Kapodistrian Univ Athens, Attikon Univ Hosp, Lab Echocardiog & Prevent Cardiol, Cardiol Dept 2,Med Sch, Athens, Greece.
   [Chania, Christina; Tsoumani, Maria; Christodoulou, Andriana; Brinia, Evangelia; Andreadou, Ioanna] Natl & Kapodistrian Univ Athens, Fac Pharm, Lab Pharmacol, Athens, Greece.
   [Iakovis, Nikolaos; Triposkiadis, Filippos] Univ Hosp Larissa, Dept Cardiol, Larisa, Greece.
   [Kountouri, Aikaterini; Korakas, Emmanouil; Lambadiari, Vaia] Natl & Kapodistrian Univ Athens, Attikon Univ Hosp, Med Sch, Dept Internal Med 2, Athens, Greece.
   [Skaltsounis, Leandros] Natl & Kapodistrian Univ Athens, Sch Pharm, Div Pharmacognosy & Nat Prod Chem, Athens, Greece.
   [Tseti, Ioulia] Intermed, Athens, Greece.
   [Ikonomidis, Ignatios; Katogiannis, Konstantinos] Natl & Kapodistrian Univ Athens, Attikon Hosp, Cardiol Dept 2, Rimini 1, Haidari 12462, Greece.
C3 National & Kapodistrian University of Athens; University Hospital
   Attikon; National & Kapodistrian University of Athens; General
   University Hospital of Larissa; National & Kapodistrian University of
   Athens; University Hospital Attikon; National & Kapodistrian University
   of Athens; National & Kapodistrian University of Athens; University
   Hospital Attikon
RP Ikonomidis, I; Katogiannis, K (corresponding author), Natl & Kapodistrian Univ Athens, Attikon Hosp, Cardiol Dept 2, Rimini 1, Haidari 12462, Greece.
EM ignoik@gmail.com; kenndj89@gmail.com
RI Andreadou, Ioanna/AAF-7284-2019; Korakas, Emmanouil/ABH-1615-2020;
   Katogiannis, Konstantinos/AAX-1156-2020; Pavlidis, George/AAU-4168-2021
OI Pavlidis, George/0000-0003-3220-3446
FU Olive Heart Operational Programme Competitiveness, Entrepreneurship and
   Innovation 2014-2020 (EPAnEK)
FX Olive Heart Operational Programme Competitiveness, Entrepreneurship and
   Innovation 2014-2020 (EPAnEK).
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NR 52
TC 17
Z9 17
U1 1
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0014-2972
EI 1365-2362
J9 EUR J CLIN INVEST
JI Eur. J. Clin. Invest.
PD JUL
PY 2023
VL 53
IS 7
AR e13983
DI 10.1111/eci.13983
EA MAR 2023
PG 14
WC Medicine, General & Internal; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Research & Experimental Medicine
GA I5PN1
UT WOS:000957972400001
PM 36912212
OA hybrid
DA 2025-06-11
ER

PT J
AU Kowalczuk, A
   Bourebaba, N
   Kornicka-Garbowska, K
   Turlej, E
   Marycz, K
   Bourebaba, L
AF Kowalczuk, Anna
   Bourebaba, Nabila
   Kornicka-Garbowska, Katarzyna
   Turlej, Eliza
   Marycz, Krzysztof
   Bourebaba, Lynda
TI Hyoscyamus albus nortropane alkaloids reduce hyperglycemia and
   hyperinsulinemia induced in HepG2 cells through the regulation of
   SIRT1/NF-kB/JNK pathway
SO CELL COMMUNICATION AND SIGNALING
LA English
DT Article
DE Hyoscyamus albus; Calystegines; Insulin Resistance; Hyperglycemia;
   HepG2; Sirt1; NF-kappa B
ID INDUCED INSULIN-RESISTANCE; STROMAL STEM-CELLS; METABOLIC SYNDROME;
   ADIPOSE-TISSUE; CBL-B; INFLAMMATION; OBESITY; INHIBITION; ACTIVATION;
   EXPRESSION
AB Background: Chronic superphysiological glucose and insulin concentrations are known to trigger several tissue and organ failures, including insulin resistance, oxidative stress and chronic low-grade inflammation. Hence, the screening for molecules that may counteract such conditions is essential in current existing therapeutic strategies, thereby the use of medicinal plant derivatives represents a promising axis in this regard.
   Methods: In this study, the effect of a selected traditional medicinal plant, Hyoscyamus albus from which, calystegines have been isolated, was investigated in an experimental model of hyperinsulinemia and hyperglycemia induced on HepG2 cells. The mRNA and protein expression levels of different insulin signaling, gluconeogenic and inflammatory pathway- related molecules were examined. Additionally, cell viability and apoptosis, oxidative stress extent and mitochondrial dysfunctions were assayed using flow cytometric and qRT-PCR techniques.
   Results: Treatment of IR HepG2 cells with calystegines strongly protected the injured cells from apoptosis, oxidative stress and mitochondrial integrity loss. Interestingly, nortropane alkaloids efficiently regulated the impaired glucose metabolism in IR HepG2 cells, through the stimulation of glucose uptake and the modulation of SIRT1/Foxo1/G6PC/mTOR pathway, which is governing the hepatic gluconeogenesis. Furthermore, the alkaloidal extract restored the defective insulin signaling pathway, mainly by promoting the expression of Insr at the mRNA and protein levels. What is more, treated cells exhibited significant mitigated inflammatory response, as evidenced by the modulation and the regulation of the NF- kappa B/JNK/TLR4 axis and the downstream proinflammatory cytokines recruitment.
   Conclusion: Overall, the present investigation demonstrates that calystegines from Hyoscyamus albus provide cytoprotection to the HepG2 cells against insulin/glucose induced insulin resistance and apoptosis due to the regulation of SIRT1/Foxo1/G6PC/mTOR and NF-kappa B/JNK/TLR4 signaling pathways.
C1 [Kowalczuk, Anna] Natl Med Inst, Chelmska 30-34, PL-00725 Warsaw, Poland.
   [Bourebaba, Nabila; Kornicka-Garbowska, Katarzyna; Marycz, Krzysztof; Bourebaba, Lynda] Int Inst Translat Med, Jesionowa 11, PL-55114 Malin, Wisznia Mala, Poland.
   [Bourebaba, Nabila; Turlej, Eliza; Bourebaba, Lynda] Wroclaw Univ Environm & Life Sci, Fac Biol & Anim Sci, Dept Expt Biol, Norwida 27B, PL-50375 Wroclaw, Poland.
   [Marycz, Krzysztof] Cardinal Stefan Wyszynski Univ UKSW, Inst Med Sci, Coll Med, Dewajtis 5, PL-01815 Warsaw, Poland.
C3 National Medicines Institute Lekow (NIL); Wroclaw University of
   Environmental & Life Sciences; Cardinal Stefan Wyszynski University in
   Warsaw
RP Bourebaba, L (corresponding author), Wroclaw Univ Environm & Life Sci, Fac Biol & Anim Sci, Dept Expt Biol, Norwida 27B, PL-50375 Wroclaw, Poland.
EM lynda.bourebaba@upwr.edu.pl
RI Marycz, Krzysztof/A-2249-2017; Bourebaba, Lynda/AAX-7613-2020;
   Bourebaba, Nabila/JRY-9553-2023
OI Lynda, Bourebaba/0000-0003-0660-8706
FU National Science Center in Poland [2018/29/B/NZ7/02662]; National
   Medicines Institute in Warsaw; International Institute of Translational
   Medicine in Malin, Poland; Leading Research Groups support project
FX The achievement of this investigation was supported by a grant obtained
   from the National Science Center in Poland intitled: 'Inhibition of
   tyrosine phosphatase as a strategy to enhance insulin sensitivity
   through activation of chaperone mediated autophagy and amelioration of
   inflammation and cellular stress in the liver of equine metabolic
   syndrome (EMS) horses.' (2018/29/B/NZ7/02662). The research has been
   also co-financed by the National Medicines Institute in Warsaw, and the
   International Institute of Translational Medicine in Malin, Poland over
   the realization of the project "Study of the influence of selected
   African medicinal plants on insulin resistance and alleviation of
   syndrome X by activating the AMPK and Akt/Pi3K pathways in hepatic
   cells". Publication fees have been supported by the Leading Research
   Groups support project from the subsidy increased for the period
   2020-2025 in the amount of 2% of the subsidy referred to Art. 387 (3) of
   the Law of 20 July 2018 on Higher Education and Science, obtained in
   2019".
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NR 56
TC 9
Z9 9
U1 4
U2 40
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1478-811X
J9 CELL COMMUN SIGNAL
JI Cell Commun. Signal.
PD MAY 25
PY 2021
VL 19
IS 1
AR 61
DI 10.1186/s12964-021-00735-w
PG 26
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA SH6GU
UT WOS:000654234200001
PM 34034759
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Alizadeh-Fanalou, S
   Babaei, M
   Hosseini, A
   Azadi, N
   Nazarizadeh, A
   Shojaii, A
   Borji, M
   Malekinejad, H
   Bahreini, E
AF Alizadeh-Fanalou, Shahin
   Babaei, Mohammad
   Hosseini, Asieh
   Azadi, Namamali
   Nazarizadeh, Ali
   Shojaii, Asie
   Borji, Mohammad
   Malekinejad, Hassan
   Bahreini, Elham
TI Effects of Securigera Securidaca seed extract in combination with
   glibenclamide on antioxidant capacity, fibroblast growth factor 21 and
   insulin resistance in hyperglycemic rats
SO JOURNAL OF ETHNOPHARMACOLOGY
LA English
DT Article
DE Antioxidant; Diabetes; FGF21; Glibenclamide; Securigera Securidaca
ID METABOLIC SYNDROME; OXIDATIVE STRESS; BLOOD-GLUCOSE; PARAOXONASE 1;
   NITRIC-OXIDE; FGF21; OBESITY; INFLAMMATION; ASSOCIATION; FLAVONOIDS
AB Ethnopharmacological relevance: Undesired effects of synthetic antidiabetic agents have made researchers to seek for safer and healthier resources. With this aspect, herbal materials have attracted substantial research interest and are being extensively investigated. Considering that herb-drug interactions can be a double-edged sword presenting both risks and benefits, investigation of such interactions is greatly in demand.
   Aim of the study: to investigate possible beneficial effects of hydroalcoholic extract of Securigera Securidaca seed (HESS) on antioxidant capacity, fibroblast growth factor 21 (FGF21) and insulin resistance in Streptozotocin (STZ)-induced diabetic rats, alone and in combination with glibenclamide.
   Materials and methods: Forty male Wistar rats were randomly divided in to eight equal groups including healthy and diabetic controls and six treated groups with a various doses of HESS alone and in combination with glibenclamide, for 35 consecutive days. Serum samples were taken and analyzed for biochemical profile, HOMA indexes, FGF21, oxidative/nitrosative stress and inflammatory biomarkers as compared with the controls. Moreover, total phenolic and flavonoid contents of herbal extract were assessed.
   Results: The herbal extract was found to be rich in flavonoid and phenolic components. Both of glibenclamide and the HESS decreased glucose and insulin resistance, as well as increased body weight and insulin sensitivity. Moreover, the extract could mitigate oxidative/nitrosative stress and inflammation dose-dependently, however, the standard drug was less effective than HESS. Induction of diabetes increased FGF21 levels and both of the treatments could reduce its contents, however, glibenclamide was more effective than HESS.
   Conclusions: The results clearly show that there is no contradiction between HESS and glibenclamide. Moreover, the herbal extract could augment antioxidant and anti-inflammatory properties of the standard drug.
C1 [Alizadeh-Fanalou, Shahin; Nazarizadeh, Ali; Bahreini, Elham] Iran Univ Med Sci, Fac Med, Dept Biochem, POB 1449614525, Tehran, Iran.
   [Babaei, Mohammad] Bu Ali Sina Univ, Fac Vet Sci, Dept Clin Sci, Hamadan, Hamadan, Iran.
   [Hosseini, Asieh] Iran Univ Med Sci, Razi Drug Res Ctr, Tehran, Iran.
   [Azadi, Namamali] Iran Univ Med Sci, Sch Publ Hlth, Dept Biostat, Tehran, Iran.
   [Shojaii, Asie] Iran Univ Med Sci, Res Inst Islamic & Complementary Med, Dept Pharmacognosy, Tehran, Iran.
   [Borji, Mohammad] Shiraz Univ Med Sci, Fac Med, Dept Biochem, Shiraz, Iran.
   [Malekinejad, Hassan] Urmia Univ Med Univ, Fac Pharm, Dept Pharmacol & Toxicol, Orumiyeh, Iran.
C3 Iran University of Medical Sciences; Bu Ali Sina University; Iran
   University of Medical Sciences; Iran University of Medical Sciences;
   Iran University of Medical Sciences; Shiraz University of Medical
   Science
RP Bahreini, E (corresponding author), Iran Univ Med Sci, Fac Med, Dept Biochem, POB 1449614525, Tehran, Iran.
EM alizadeh.sh@tak.iums.ac.ir; mohammad.babaei@basu.ac.ir;
   hoseini.as@iums.ac.ir; azadi.n@iums.ac.ir; ali2nazarizadeh@gmail.com;
   shojaii.a@iums.ac.ir; mohammadborji32@yahoo.com;
   Hassanmalekinejad@yahoo.com; Bahreini.e@iums.ac.ir
RI Shojaii, Asie/T-2733-2019; Hosseini, Asieh/I-2996-2012; Bahreini,
   Elham/AAT-7055-2021; Borji, Mohammad/IAP-2940-2023; Nazarizadeh
   Khangheshlaghi, Ali/I-6753-2016; Azadi, Nammam/H-4236-2018; Babaei,
   Mohammad/R-1188-2019
OI Shojaii, Asie/0000-0002-9093-5525; Nazarizadeh Khangheshlaghi,
   Ali/0000-0003-0935-5142; Bahreini, Elham/0000-0001-6823-8638;
   Alizadeh-Fanalou, Shahin/0000-0003-0448-7074; Azadi,
   Nammam/0000-0001-7983-6318; Babaei, Mohammad/0000-0002-1517-7162
FU Iran University of Medical Sciences [95-01-30-27815]
FX This project was supported by Iran University of Medical Sciences with
   grant No: 95-01-30-27815. We sincerely thanks to the members of the
   Biochemistry Department of Iran University of Medical Sciences for their
   favors in improving this study.
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NR 59
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Z9 15
U1 1
U2 19
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0378-8741
EI 1872-7573
J9 J ETHNOPHARMACOL
JI J. Ethnopharmacol.
PD FEB 10
PY 2020
VL 248
AR 112331
DI 10.1016/j.jep.2019.112331
PG 11
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA JW8QY
UT WOS:000503312800040
PM 31655149
DA 2025-06-11
ER

PT J
AU Abdel-Hamid, AAM
   Firgany, AEL
AF Abdel-Hamid, Ahmed A. M.
   Firgany, Alaa El-Din L.
TI Favorable outcomes of hydroxychloroquine in insulin resistance may be
   accomplished by adjustment of the endothelial dysfunction as well as the
   skewed balance of adipokines
SO ACTA HISTOCHEMICA
LA English
DT Article
DE Hydroxychloroquine; Insulin resistance; beta-Cells; Islets neogenesis;
   Adipokines; sE-selectin; sICAM-1; sVCAM-1
ID SOLUBLE ADHESION MOLECULES; IMPAIRED GLUCOSE-TOLERANCE; BETA-CELL
   FUNCTION; RHEUMATOID-ARTHRITIS; DIABETES-MELLITUS; ENDOCRINE PANCREAS;
   METABOLIC SYNDROME; RANDOMIZED-TRIAL; LIPID PROFILE; OBESITY
AB Hydroxychloroquine (HCQ) has been demonstrated to reduce the risk to develop diabetes mellitus (DM). However no previous experimental study had investigated its effect on the structure of the endocrine pancreas, islets of Langerhans (IOL), in insulin resistance (IR). In addition, the mechanism by which HCQ can prevent DM is not well understood. In this study, we hypothesized that the possible favorable outcome of HCQ may be partly achieved by its molecular effect on the endothelial stress markers as well as on the imparied balance of the adipokines that usually accompanies IR.
   A total of 54 rats were divided equally into; control, high fat diet (HFD) and HFD + HCQgroups (received standard chow, HFD and HFD + HCQ respectively). After 12 weeks, samples from pancreas as well as visceral adipose tissue (VAT) were histologically studied for the consequent changes.
   In the HFD group, there were mild degenerative changes and expansion of the IOL accompanied with a significantly increased (p < 0.05) beta-cell area%, mass, proliferation and neogenesis as well as a significantly decreased (p < 0.05) alpha-cell area% compared with the other groups. On combining HCQ with HFD, reversal of these changes along with correction of the impaired adipokines levels (leptin, adiponectin, resistin, visfatin and lipocalin-2) and significant decrease (p < 0.05) of the vascular endothelial stress markers (sE-selectin, sICAM and sVICAM) were manifested compared with the HFD group.
   Therefore, HCQ favorable effects in IR may be attributed to relieving of the endothelial stress as well as normalization of the skewed balance of adipokines. (C) 2016 Elsevier GmbH. All rights reserved.
C1 [Abdel-Hamid, Ahmed A. M.; Firgany, Alaa El-Din L.] Mansoura Univ, Dept Histol & Cell Biol, Fac Med, PO 35516, Mansoura, Egypt.
C3 Egyptian Knowledge Bank (EKB); Mansoura University
RP Abdel-Hamid, AAM (corresponding author), Mansoura Univ, Dept Histol & Cell Biol, Fac Med, PO 35516, Mansoura, Egypt.
EM drahmadabdelhamid@gmail.com
RI firgany, alaa/P-9964-2018; Abdel-Hamid, Ahmed/L-3998-2016
OI Firgany, Alaa eldin/0000-0001-7057-8025; Abdel-Hamid,
   Ahmed/0000-0001-5444-4609
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NR 57
TC 25
Z9 25
U1 0
U2 1
PU ELSEVIER GMBH, URBAN & FISCHER VERLAG
PI JENA
PA OFFICE JENA, P O BOX 100537, 07705 JENA, GERMANY
SN 0065-1281
EI 1618-0372
J9 ACTA HISTOCHEM
JI Acta Histochem.
PY 2016
VL 118
IS 6
BP 560
EP 573
DI 10.1016/j.acthis.2016.06.002
PG 14
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA DV6AC
UT WOS:000383010800002
PM 27320898
DA 2025-06-11
ER

PT J
AU Woods, NF
   Carr, MC
   Tao, EY
   Taylor, HJ
   Mitchell, ES
AF Woods, NF
   Carr, MC
   Tao, EY
   Taylor, HJ
   Mitchell, ES
TI Increased urinary cortisol levels during the menopausal transition
SO MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY
LA English
DT Article
DE adrenal; menopausal transition; postmenopause; cortisol
ID METABOLIC SYNDROME; SEXUAL-DIMORPHISM; OVARIAN-FUNCTION;
   STRESS-RESPONSE; HORMONE LEVELS; MIDLIFE WOMEN; EXPERIENCES; POPULATION;
   MACARTHUR; EXCRETION
AB Objective: To determine whether cortisol levels change prospectively during the menopausal transition (MT); whether these changes are associated with changes in the hypothalamic-pituitary-ovarian axis (follicle-stimulating hormone [FSH] and estrone glucuronide [E1G]), stressors, or menopause symptoms; and whether women who experienced a rise in cortisol levels during the transition had behavioral practices, stressors, vasomotor symptoms, or mood or sleep disturbances that affected hypothalamic-pituitary-adrenal axis function.
   Design: One hundred sixty-nine women in the middle or late MT or early postmenopause stages provided monthly urine specimens for cortisol, FSH, and E1G, and rated symptoms and stress levels as part of a longitudinal study of the MT. Of these women, 91 completed a transition to the next NIT stage: from early to middle (n = 30), middle to late (n = 39), or late to postmenopause (n = 22) and were eligible for inclusion in the analyses.
   Results: Cortisol increased from 7 to 12 months before the late MT stage to 7 to 12 months after onset of the late NIT stage. There were no differences before and after the middle NIT stage or the final menstrual period. Women with increased coitisol (> 10 ng/mg creatinine) during the late MT stage had more severe vasomotor symptoms than those without changes, but did not differ in terms of age, body mass index, levels of FSH or E I G, health practices, exercise, mood, sleep, cognition, or stress levels.
   Conclusions: Cortisol levels rise with age, but have not been linked to stages of the MT. Increased cortisol levels during the late MT stage, when menstrual irregularities are greatest, suggest increases in adrenal androgens and intruabdominal fat with menopause, and may influence risk of cardiovascular disease, vasomotor symptoms, mood, cognition, and bone loss.
C1 Univ Washington, Sch Nursing, Dept Family & Child Nursing, Seattle, WA 98195 USA.
   Univ Washington, Div Metab Endocrinol & Nutr, Seattle, WA 98195 USA.
   Univ Washington, Dept Biobehav Nursing & Hlth Syst, Seattle, WA 98195 USA.
C3 University of Washington; University of Washington Seattle; University
   of Washington; University of Washington Seattle; University of
   Washington; University of Washington Seattle
RP Univ Washington, Sch Nursing, Dept Family & Child Nursing, T318,Hlth Sci Bldg,Box 357260, Seattle, WA 98195 USA.
EM nfwoods@u.washington.edu
FU NCRR NIH HHS [K23 RR16067] Funding Source: Medline; NINR NIH HHS
   [NR0414, P30-NR04001, P50-NR-02323] Funding Source: Medline
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NR 40
TC 75
Z9 80
U1 0
U2 7
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1072-3714
EI 1530-0374
J9 MENOPAUSE
JI Menopause-J. N. Am. Menopause Soc.
PD MAR-APR
PY 2006
VL 13
IS 2
BP 212
EP 221
DI 10.1097/01.gme.0000198490.57242.2e
PG 10
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA 031NQ
UT WOS:000236711700011
PM 16645535
DA 2025-06-11
ER

PT J
AU Rossi, F
   Di Paola, A
   Pota, E
   Argenziano, M
   Di Pinto, D
   Marrapodi, MM
   Di Leva, C
   Di Martino, M
   Tortora, C
AF Rossi, Francesca
   Di Paola, Alessandra
   Pota, Elvira
   Argenziano, Maura
   Di Pinto, Daniela
   Marrapodi, Maria Maddalena
   Di Leva, Caterina
   Di Martino, Martina
   Tortora, Chiara
TI Biological Aspects of Inflamm-Aging in Childhood Cancer Survivors
SO CANCERS
LA English
DT Review
DE childhood cancer survivors; inflamm-aging; frailty; immune system;
   oxidative stress; senescence; therapeutic strategies
ID HEMATOPOIETIC-CELL TRANSPLANTATION; SENESCENT SECRETORY PHENOTYPE;
   GLYCATION END-PRODUCTS; YOUNG-ADULT SURVIVORS; PHYSICAL-ACTIVITY;
   LONG-TERM; METABOLIC SYNDROME; OXIDATIVE STRESS; CARDIOVASCULAR EVENTS;
   PERIPHERAL-BLOOD
AB Simple Summary: Around 80% of children treated for childhood cancer become long-term survivors. Although chemotherapy and radiotherapy improve survival of these patients, they cause a low-grade chronic inflammation (inflamm-aging) which induces premature aging processes and vital organ failure, a condition known as frailty. Understanding frailty's biological and molecular mechanisms and identifying inflamm-aging key biomarkers in childhood cancer survivors could be useful to facilitate the screening of comorbidities and to understand whether treatments, used to counteract inflamm-aging, may prevent side effects.
   Anti-cancer treatments improve survival in children with cancer. A total of 80% of children treated for childhood cancer achieve 5-year survival, becoming long-term survivors. However, they undergo several chronic late effects related to treatments. In childhood cancer survivors a chronic low-grade inflammation, known as inflamm-aging, is responsible for frailty, a condition characterized by vital organ failure and by premature aging processes. Inflamm-aging is closely related to chemotherapy and radiotherapy, which induce inflammation, accumulation of senescent cells, DNA mutations, and the production of reactive oxygen species. All these conditions are responsible for the onset of secondary diseases, such as osteoporosis, cardiovascular diseases, obesity, and infertility. Considering that the pathobiology of frailty among childhood cancer survivors is still unknown, investigations are needed to better understand frailty's biological and molecular processes and to identify inflamm-aging key biomarkers in order to facilitate the screening of comorbidities and to clarify whether treatments, normally used to modulate inflamm-aging, may be beneficial. This review offers an overview of the possible biological mechanisms involved in the development of inflamm-aging, focusing our attention on immune system alteration, oxidative stress, cellular senescence, and therapeutic strategies.
C1 [Rossi, Francesca; Pota, Elvira; Argenziano, Maura; Di Pinto, Daniela; Marrapodi, Maria Maddalena; Di Leva, Caterina; Di Martino, Martina; Tortora, Chiara] Univ Campania Luigi Vanvitelli, Dept Woman Child & Gen & Specialist Surg, Via L De Crecchio 4, I-80138 Naples, Italy.
   [Di Paola, Alessandra] Univ Campania Luigi Vanvitelli, Dept Expt Med, Via S Maria Costantinopoli 16, I-80138 Naples, Italy.
C3 Universita della Campania Vanvitelli; Universita della Campania
   Vanvitelli
RP Rossi, F (corresponding author), Univ Campania Luigi Vanvitelli, Dept Woman Child & Gen & Specialist Surg, Via L De Crecchio 4, I-80138 Naples, Italy.
EM francesca.rossi@unicampania.it; alessandra.dipaola@unicampania.it;
   elvira.pota@unicampania.it; maura.argenziano@unicampania.it;
   daniela.dipinto@unicampania.it;
   mariamaddalena.marrapodi@studenti.unicampania.it;
   caterinadl.94@gmail.com; martina.dimartino@unicampania.it;
   chiara.tortora@unicampania.it
RI Di Paola, Alessandra/LUA-0359-2024; Rossi, Francesca/HTP-5870-2023
OI Argenziano, Maura/0000-0003-4457-1318; Di Paola,
   Alessandra/0000-0001-5634-3967; Rossi, Francesca/0000-0003-2879-6277
FU In-CHICAS [VALERE19]
FX This research was funded by VALERE19 "In-CHICAS".
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NR 183
TC 25
Z9 25
U1 0
U2 1
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6694
J9 CANCERS
JI Cancers
PD OCT
PY 2021
VL 13
IS 19
AR 4933
DI 10.3390/cancers13194933
PG 19
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA 0A4JQ
UT WOS:000773923000040
PM 34638416
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Mazo, T
   D'Annunzio, V
   Zaobornyj, T
   Perez, V
   Gomez, A
   Berg, G
   Barchuk, M
   Ossani, G
   Martinefski, M
   Tripodi, V
   Lago, N
   Gelpi, RJ
AF Mazo, Tamara
   D'Annunzio, Veronica
   Zaobornyj, Tamara
   Perez, Virginia
   Gomez, Anabella
   Berg, Gabriela
   Barchuk, Magali
   Ossani, Georgina
   Martinefski, Manuela
   Tripodi, Valeria
   Lago, Nestor
   Gelpi, Ricardo J.
TI High-fat diet abolishes the cardioprotective effects of ischemic
   postconditioning in murine models despite increased thioredoxin-1 levels
SO MOLECULAR AND CELLULAR BIOCHEMISTRY
LA English
DT Article
DE High-fat diet; Thioredoxin; Ischemic postconditioning; Oxidative stress
ID INFARCT SIZE; REPERFUSION INJURY; METABOLIC SYNDROME; OXIDATIVE STRESS;
   TRANSGENIC MICE; HYPERCHOLESTEROLEMIA; COMORBIDITIES; DYSFUNCTION;
   ACTIVATION; REDUCTASE
AB Ischemic postconditioning (PostC) reduces infarct size in healthy experimental models. However, if protective effects of PostC are abolished during early stages of atherosclerotic and if this is related with a disbalance in mitochondrial energetics and alterations in thioredoxin-1 (Trx1) is still unknown. The objectives were to generate a murine high-fat diet (HFD)-fed model that developed in a phenotype consistent with early stages of atherosclerosis to then evaluate whether HFD exposure increased oxidative stress and consequently abolished the cardioprotection conferred by PostC. We used C57/BL6 mice fed with control diet (CD) or HFD for 12 weeks. Isolated mice hearts were subjected to 30min of ischemia and 120min of reperfusion (I/R group). For PostC group, after ischemia, six cycles of reperfusion/ischemia were performed (10s per cycle) at the onset of reperfusion. In CD group, the PostC reduced infarct size (CD-I/R: 52.14 +/- 2.8 vs. CD-PostC: 36.58 +/- 1.8, P<0.05) and increased phosphorylation of GSK3 (CD-PostC: 2.341 +/- 1.03 vs. CD-Baseline: 0.923 +/- 0.41 AUOD, P<0.05), and this cardioprotection was abolished in HFD-exposed mice. HFD increased hydrogen peroxidelevels, produced a shift towards an oxidized intracellular environment (GSSG/GSH(2)), and increased Trx1 expression with higher fractions of oxidized protein. State 3 mitochondrial oxygen consumption in basal conditions decreased 24% in HFD-exposed mice and PostC improved state 3 values only in CD mice. Cellular redox state and mitochondrial bioenergetics were altered in HFD-exposed mice. We demonstrated that alterations in redox state at early stages of atherosclerosis abolished cardioprotective mechanisms, such as those induced by PostC, even with increased Trx1 levels.
C1 [Mazo, Tamara; D'Annunzio, Veronica; Perez, Virginia; Gomez, Anabella; Gelpi, Ricardo J.] Univ Buenos Aires, Inst Cardiovasc Physiopathol, Fac Med, Dept Pathol, JE Uriburu 950,2nd Floor, Buenos Aires, DF, Argentina.
   [Zaobornyj, Tamara] Univ Buenos Aires, Inst Biochem & Mol Med IBIMOL UBA CONICET, Sch Pharm & Biochem, Buenos Aires, DF, Argentina.
   [Mazo, Tamara; D'Annunzio, Veronica; Perez, Virginia; Gomez, Anabella; Gelpi, Ricardo J.] Univ Buenos Aires, Inst Biochem & Mol Med IBIMOL UBA CONICET, Fac Med, Buenos Aires, DF, Argentina.
   [Berg, Gabriela; Barchuk, Magali] Univ Buenos Aires, Sch Pharm & Biochem, Dept Clin Biochem, Lab Lipids & Atherosclerosis, Buenos Aires, DF, Argentina.
   [Ossani, Georgina; Lago, Nestor] Univ Buenos Aires, Dept Pathol, Expt & Appl Pathol Ctr, Fac Med, Buenos Aires, DF, Argentina.
   [Martinefski, Manuela; Tripodi, Valeria] Univ Buenos Aires, Sch Pharm & Biochem, Dept Pharmaceut Technol, Buenos Aires, DF, Argentina.
C3 University of Buenos Aires; Instituto Cardiovascular de Buenos Aires
   (ICBA); University of Buenos Aires; University of Buenos Aires;
   University of Buenos Aires; University of Buenos Aires; University of
   Buenos Aires
RP Gelpi, RJ (corresponding author), Univ Buenos Aires, Inst Cardiovasc Physiopathol, Fac Med, Dept Pathol, JE Uriburu 950,2nd Floor, Buenos Aires, DF, Argentina.; Gelpi, RJ (corresponding author), Univ Buenos Aires, Inst Biochem & Mol Med IBIMOL UBA CONICET, Fac Med, Buenos Aires, DF, Argentina.
EM rgelpi@fmed.uba.ar
OI Gomez, Anabella Cecilia/0009-0002-1293-1649; Berg,
   Gabriela/0000-0002-5787-8960; Martinefski, Manuela
   Romina/0000-0002-4501-3783; Lago, Nestor/0000-0002-7633-8687
FU University of Buenos Aires (UBACYT) [20020110100159]; National Agency
   for Technological and Scientific Promotion [PICT 0373]; CONICET [PIP
   2014/0012]
FX This study was supported by the University of Buenos Aires (UBACYT#
   20020110100159); and the National Agency for Technological and
   Scientific Promotion (PICT 0373) and CONICET (PIP 2014/0012).
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NR 43
TC 5
Z9 7
U1 0
U2 12
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0300-8177
EI 1573-4919
J9 MOL CELL BIOCHEM
JI Mol. Cell. Biochem.
PD FEB
PY 2019
VL 452
IS 1-2
BP 153
EP 166
DI 10.1007/s11010-018-3421-x
PG 14
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA HK5XG
UT WOS:000458042200015
PM 30094601
DA 2025-06-11
ER

PT J
AU Selenscig, D
   Ferreira, MD
   Chicco, A
   Lombardo, YB
AF Selenscig, Dante
   del Rosario Ferreira, Maria
   Chicco, Adriana
   Lombardo, Yolanda B.
TI Dietary fish oil ameliorates adipose tissue dysfunction in
   insulin-resistant rats fed a sucrose-rich diet improving oxidative
   stress, peroxisome proliferator-activated receptor γ and uncoupling
   protein 2
SO FOOD & FUNCTION
LA English
DT Article
ID POLYUNSATURATED FATTY-ACIDS; NECROSIS-FACTOR-ALPHA; INDUCED OBESE MICE;
   METABOLIC SYNDROME; 3T3-L1 ADIPOCYTES; INFLAMMATORY CYTOKINES; NUCLEAR
   RECEPTORS; ENZYME-ACTIVITIES; LIPID-METABOLISM; GENE-EXPRESSION
AB This work aims to assess the possible beneficial effects of dietary fish oil (FO) on the pre-existing adipose tissue dysfunction through the improvement or reversion of the mechanisms underlying oxidative stress and pro-inflammatory cytokines in dyslipemic insulin-resistant rats. Wistar rats were fed a sucrose rich diet (SRD) for 6 months. After that half of the animals continued with the SRD until month 8 while in the other half corn oil was replaced by FO for 2 months (SRD + FO). A reference group consumed a control diet all the time. In an epididymal fat pad, we analyzed antioxidant and oxidant enzyme activities, ROS content, glutathione redox state, the protein level of peroxisome proliferator-activated receptor gamma (PPAR gamma) and the expression and protein levels of uncoupling protein 2 (UCP2) as well as oxidative stress biomarkers and TNF-alpha and IL-6 plasma levels. Besides these, insulin sensitivity and the composition of fatty acid phospholipids of adipose tissue were measured. Compared with the SRD the SRD + FO fed group showed a decrease of fat pad weight and the antioxidant and oxidant enzyme activities and ROS content returned to control values along with normal plasma TNF-alpha and IL-6 levels. FO normalized both the decrease of PPAR gamma protein and the increase of protein and expression of UCP2. Furthermore, FO increased the n-3/n-6 fatty acid ratio in the adipose tissue phospholipids and normalized dyslipidemia and insulin resistance. Finally, these findings reinforce the view that dietary FO may exert a beneficial effect in ameliorating the dyslipidemia and insulin resistance in this animal model.
C1 [Lombardo, Yolanda B.] Univ Litoral, Sch Biochem, Dept Biochem, Ciudad Univ,Paraje El Pozo,CC 242, RA-3000 Santa Fe, Argentina.
   Consejo Nacl Invest Cient & Tecn, Santa Fe, Argentina.
C3 National University of the Littoral; Consejo Nacional de Investigaciones
   Cientificas y Tecnicas (CONICET)
RP Lombardo, YB (corresponding author), Univ Litoral, Sch Biochem, Dept Biochem, Ciudad Univ,Paraje El Pozo,CC 242, RA-3000 Santa Fe, Argentina.
EM ylombard@fbcb.unl.edu.ar
OI Ferreira, Maria del Rosario/0000-0003-0760-9495
FU Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET)
   [PIP 0105]; University of Litoral [CAI+D 0058 LI-2012]
FX The present study was carried out with the financial support of Consejo
   Nacional de Investigaciones Cientificas y Tecnicas (CONICET) (Grant PIP
   0105) and University of Litoral (CAI+D 0058 LI-2012).
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NR 66
TC 5
Z9 5
U1 0
U2 8
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PD APR 1
PY 2018
VL 9
IS 4
BP 2496
EP 2507
DI 10.1039/c7fo01993a
PG 12
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA GK3GV
UT WOS:000436031600053
PM 29645025
OA Green Published
DA 2025-06-11
ER

PT J
AU Chatzitomaris, A
   Hoermann, R
   Midgley, JE
   Hering, S
   Urban, A
   Dietrich, B
   Abood, A
   Klein, HH
   Dietrich, JW
AF Chatzitomaris, Apostolos
   Hoermann, Rudolf
   Midgley, John E.
   Hering, Steffen
   Urban, Aline
   Dietrich, Barbara
   Abood, Assjana
   Klein, Harald H.
   Dietrich, Johannes W.
TI Thyroid Allostasis-Adaptive Responses of Thyrotropic Feedback Control to
   Conditions of Strain, Stress, and Developmental Programming
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Review
DE thyroid allostasis; non-thyroidal illness syndrome; thyroid hormone
   metabolism; hypothalamus pituitary-thyroid feedback control; TACITUS
   syndrome
ID NONTHYROIDAL ILLNESS SYNDROME; TYPE-2 IODOTHYRONINE DEIODINASE;
   HORMONE-SYNTHESIZING NEURONS; HUMAN CHORIONIC-GONADOTROPIN;
   THYROXINE-BINDING GLOBULIN; BROWN ADIPOSE-TISSUE; HYPOTHALAMIC
   PARAVENTRICULAR NUCLEUS; SERUM TRIIODOTHYRONINE CONCENTRATION;
   CLINICAL-PRACTICE GUIDELINES; STRONG PROGNOSTIC PREDICTOR
AB The hypothalamus-pituitary-thyroid feedback control is a dynamic, adaptive system. In situations of illness and deprivation of energy representing type 1 allostasis, the stress response operates to alter both its set point and peripheral transfer parameters. In contrast, type 2 allostatic load, typically effective in psychosocial stress, pregnancy, metabolic syndrome, and adaptation to cold, produces a nearly opposite phenotype of predictive plasticity. The non-thyroidal illness syndrome (NTIS) or thyroid allostasis in critical illness, tumors, uremia, and starvation (TACITUS), commonly observed in hospitalized patients, displays a historically well-studied pattern of allostatic thyroid response. This is characterized by decreased total and free thyroid hormone concentrations and varying levels of thyroid-stimulating hormone (TSH) ranging from decreased (in severe cases) to normal or even elevated (mainly in the recovery phase) TSH concentrations. An acute versus chronic stage (wasting syndrome) of TACITUS can be discerned. The two types differ in molecular mechanisms and prognosis. The acute adaptation of thyroid hormone metabolism to critical illness may prove beneficial to the organism, whereas the far more complex molecular alterations associated with chronic illness frequently lead to allostatic overload. The latter is associated with poor outcome, independently of the underlying disease. Adaptive responses of thyroid homeostasis extend to alterations in thyroid hormone concentrations during fetal life, periods of weight gain or loss, thermoregulation, physical exercise, and psychiatric diseases. The various forms of thyroid allostasis pose serious problems in differential diagnosis of thyroid disease. This review article provides an overview of physiological mechanisms as well as major diagnostic and therapeutic implications of thyroid allostasis under a variety of developmental and straining conditions.
C1 [Chatzitomaris, Apostolos; Abood, Assjana; Klein, Harald H.; Dietrich, Johannes W.] Ruhr Univ Bochum, Bergmannsheil Univ Hosp, Med Dept 1, Endocrinol & Diabetol, Bochum, Germany.
   [Hoermann, Rudolf] Private Consultancy, Res & Dev, Yandina, Qld, Australia.
   [Midgley, John E.] North Lakes Clin, Ilkley, England.
   [Hering, Steffen] Krankenhaus Bietigheim Vaihingen, Dept Internal Med Cardiol Endocrinol Diabet & Med, Bietigheim Bissingen, Germany.
   [Urban, Aline] Eastern Allgau Kaufbeuren Hosp, Dept Anesthesiol Intens Care & Palliat Med, Kaufbeuren, Germany.
   [Dietrich, Barbara] Klinikum Munchen Ost, Kbo Isar Amper Klinikum, Haar, Germany.
   [Klein, Harald H.; Dietrich, Johannes W.] Ruhr Univ Bochum, Ruhr Ctr Rare Dis CeSER, Bochum, Germany.
   [Klein, Harald H.; Dietrich, Johannes W.] Witten Herdecke Univ, Bochum, Germany.
C3 Ruhr University Bochum; Ruhr University Bochum
RP Chatzitomaris, A (corresponding author), Ruhr Univ Bochum, Bergmannsheil Univ Hosp, Med Dept 1, Endocrinol & Diabetol, Bochum, Germany.
EM apostolos.chatzitomaris@ruhr-uni-bochum.de
RI Hoermann, Rudolf/MEO-8455-2025; Dietrich, Johannes W./C-3498-2009
OI Hoermann, Rudolf/0000-0002-1326-4270; Dietrich, Johannes
   W./0000-0002-1185-3549
FU DFG Open Access Publication Funds of the Ruhr-Universitat Bochum
FX Writing of this review article did not receive any specific grant from
   any funding agency in the public, commercial, or not-for profit sector.
   We acknowledge support by the DFG Open Access Publication Funds of the
   Ruhr-Universitat Bochum.
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NR 424
TC 108
Z9 112
U1 3
U2 31
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD JUL 20
PY 2017
VL 8
AR 163
DI 10.3389/fendo.2017.00163
PG 28
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism
GA FB7IN
UT WOS:000406314400001
PM 28775711
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Khoo, NKH
   Cantu-Medellin, N
   Devlin, JE
   St Croix, CM
   Watkins, SC
   Fleming, AM
   Champion, HC
   Mason, RP
   Freeman, BA
   Kelley, EE
AF Khoo, Nicholas K. H.
   Cantu-Medellin, Nadiezhda
   Devlin, Jason E.
   St Croix, Claudette M.
   Watkins, Simon C.
   Fleming, Alexander M.
   Champion, Hunter C.
   Mason, Ronald P.
   Freeman, Bruce A.
   Kelley, Eric E.
TI Obesity-induced tissue free radical generation: An in vivo
   immuno-spin trapping study
SO FREE RADICAL BIOLOGY AND MEDICINE
LA English
DT Article
DE Free radicals; Immuno-spin trapping; Obesity; Inflammation; Oxidative
   stress
ID OXIDATIVE STRESS; REACTIVE OXYGEN; MITOCHONDRIAL DYSFUNCTION;
   PULMONARY-HYPERTENSION; METABOLIC SYNDROME; SKELETAL-MUSCLE; PROTEIN;
   DIET; NITROGEN; KIDNEY
AB Assessment of tissue free radical production is routinely accomplished by measuring secondary by-products of redox reactions and/or diminution of key antioxidants such as reduced thiols. However, immuno-spin trapping, a newly developed immunohistochemical technique for detection of free radical formation, is garnering considerable interest as it allows for the visualization of 5,5-dimethyl-1-pyrroline N-oxide (DMPO)-adducted molecules. Yet, to date, immuno-spin trapping reports have utilized in vivo models in which successful detection of free radical adducts required exposure to lethal levels of oxidative stress not reflective of chronic inflammatory disease. To study the extents and anatomic locations of more clinically relevant levels of radical formation, we examined tissues from high-fat (HF) diet-fed mice, a model of low-grade chronic inflammation known to demonstrate enhanced rates of reactive species production. Mice subjected to 20 weeks of HF diet displayed increased free radical formation (anti-DMPO mean fluorescence staining) in skeletal muscle (0.863 +/- 0.06 units vs 0.512 +/- 0.07 units), kidney (0.076 +/- 0.0036 vs 0.043 +/- 0.0025), and liver (0.275 +/- 0.012 vs 0.135 +/- 0.014) compared to control mice fed normal laboratory chow (NC). Western blot analysis of tissue homogenates confirmed these results showing enhanced DMPO immunoreactivity in HF mice compared to NC samples. The obesity-related results were confirmed in a rat model of pulmonary hypertension and right heart failure in which intense immunodetectable radical formation was observed in the lung and right ventricle of monocrotaline-treated rats compared to saline-treated controls. Combined, these data affirm the utility of immuno-spin trapping as a tool for in vivo assessment of altered extents of macromolecule oxidation to radical intermediates under chronic inflammatory conditions. Published by Elsevier Inc.
C1 [Cantu-Medellin, Nadiezhda; Fleming, Alexander M.; Kelley, Eric E.] Univ Pittsburgh, Sch Med, Dept Anesthesiol, Pittsburgh, PA 15213 USA.
   [Khoo, Nicholas K. H.; Freeman, Bruce A.; Kelley, Eric E.] Univ Pittsburgh, Sch Med, Dept Pharmacol & Chem Biol, Pittsburgh, PA 15213 USA.
   [Cantu-Medellin, Nadiezhda; Champion, Hunter C.; Kelley, Eric E.] Univ Pittsburgh, Sch Med, Vasc Med Inst, Pittsburgh, PA 15213 USA.
   [Devlin, Jason E.; St Croix, Claudette M.; Watkins, Simon C.] Univ Pittsburgh, Sch Med, Ctr Biol Imaging, Pittsburgh, PA 15213 USA.
   [Mason, Ronald P.] NIEHS, Lab Pharmacol & Toxicol, Res Triangle Pk, NC 27709 USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE); University
   of Pittsburgh; Pennsylvania Commonwealth System of Higher Education
   (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of
   Higher Education (PCSHE); University of Pittsburgh; Pennsylvania
   Commonwealth System of Higher Education (PCSHE); University of
   Pittsburgh; National Institutes of Health (NIH) - USA; NIH National
   Institute of Environmental Health Sciences (NIEHS)
RP Kelley, EE (corresponding author), Univ Pittsburgh, Sch Med, Dept Anesthesiol, W-1357 Biomed Sci Tower,200 Lothrop St, Pittsburgh, PA 15213 USA.
EM ekelley@pitt.edu
RI Watkins, Simon/ABG-2590-2021; Freeman, Bruce/H-9342-2012; St Croix,
   Claudette/AAA-3338-2022; Mason, Ronald P./G-5967-2019
OI watkins, simon/0000-0003-4092-1552; Mason, Ronald P./0000-0002-1859-9109
FU American Heart Association [R01-HL058115, R01-HL64937, P01-HL103455];
   Gilead Sciences Research Scholars Program in Pulmonary Arterial
   Hypertension
FX This work was funded by the American Heart Association, a National
   Scientist Development grant (E.E.K.), R01-HL058115, R01-HL64937,
   P01-HL103455 (B.A.F.), and the Gilead Sciences Research Scholars Program
   in Pulmonary Arterial Hypertension (N.K.H.K.)
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NR 24
TC 30
Z9 32
U1 0
U2 15
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0891-5849
J9 FREE RADICAL BIO MED
JI Free Radic. Biol. Med.
PD JUN 1
PY 2012
VL 52
IS 11-12
BP 2312
EP 2319
DI 10.1016/j.freeradbiomed.2012.04.011
PG 8
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 966SI
UT WOS:000305857300017
PM 22564528
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Marsillach, J
   Aragonès, G
   Mackness, B
   Mackness, M
   Rull, A
   Beltrán-Debón, R
   Pedro-Botet, J
   Alonso-Villaverde, C
   Joven, J
   Camps, J
AF Marsillach, Judit
   Aragones, Gerard
   Mackness, Bharti
   Mackness, Michael
   Rull, Anna
   Beltran-Debon, Raul
   Pedro-Botet, Juan
   Alonso-Villaverde, Carlos
   Joven, Jorge
   Camps, Jordi
TI Decreased paraoxonase-1 activity is associated with alterations of
   high-density lipoprotein particles in chronic liver impairment
SO LIPIDS IN HEALTH AND DISEASE
LA English
DT Article
ID MONOCYTE CHEMOATTRACTANT PROTEIN-1; PHOSPHOLIPID TRANSFER PROTEIN;
   MACROPHAGE OXIDATIVE STRESS; ESTER TRANSFER PROTEIN; SERUM PARAOXONASE;
   HEPATIC INFLAMMATION; BIOLOGICAL-ACTIVITY; METABOLIC SYNDROME; HDL3
   PARTICLES; MICE
AB Background: Paraoxonase-1 (PON1), a lactonase synthesized by the liver, circulates in blood bound to high-density lipoproteins (HDL). This enzyme is thought to degrade oxidized phospholipids and play an important role in the organism's antioxidant and anti-inflammatory system. Chronic liver diseases are characterized by decreased serum PON1 activity. The aim of the present study was to investigate the compositional changes in HDL that could influence PON1 activity in liver impairment.
   Methods: The study was performed in samples from five patients with advanced liver cirrhosis and with preserved renal function, chosen on the basis of having low serum PON1 activity and high serum PON1 concentration. As a control group, we accessed five healthy volunteers from among our hospital staff. Lipid and protein compositional analysis of lipoprotein particles were done by high-performance liquid chromatography, gel electrophoresis, and Western-Blot.
   Results: HDL particles from cirrhotic patients had an increased phospholipid content that was inversely correlated to PON1 activity. The HDL particles contained high levels of PON1 that corresponded, in part, to an immunoreactive protein of high molecular weight (55 kDa) not present in control subjects. This protein was identified as glycosylated PON1 and was also present in biopsies from patients with steatosis and from rats with CCl4-induced hepatic impairment. These changes were associated with an increased plasma concentration of markers of oxidative stress, inflammation and fibrogenesis.
   Conclusion: Abnormalities in the composition of lipids and proteins of HDL particles, including PON1 glycosylation, are associated with the decrease in serum PON1 activity in patients with liver disease. These alterations may adversely affect the protective role of HDL against oxidative stress and inflammation in these patients.
C1 [Marsillach, Judit; Aragones, Gerard; Mackness, Bharti; Mackness, Michael; Rull, Anna; Beltran-Debon, Raul; Alonso-Villaverde, Carlos; Joven, Jorge; Camps, Jordi] Univ Rovira & Virgili, Inst Invest Sanitaria Pere Virgili, Ctr Recerca Biomed, Reus 43201, Catalunya, Spain.
   [Pedro-Botet, Juan] Hosp del Mar, Dept Internal Med, Inst Municipal Assistencia Sanitaria, Barcelona 08003, Catalunya, Spain.
C3 Universitat Rovira i Virgili; Institut d'Investigacio Sanitaria Pere
   Virgili (IISPV); Hospital del Mar Research Institute; Hospital del Mar
RP Camps, J (corresponding author), Univ Rovira & Virgili, Inst Invest Sanitaria Pere Virgili, Ctr Recerca Biomed, C St Joan S-N, Reus 43201, Catalunya, Spain.
EM jcamps@grupsagessa.cat
RI Aragonès, Gerard/AAJ-9150-2021; Rull, Anna/A-9438-2017; Camps,
   Jordi/AAG-3080-2020; Marsillach, Judit/I-1329-2015; Aragones,
   Gerard/F-9673-2016; Beltran-Debon, Raul/A-9287-2014; Joven,
   Jorge/B-3360-2016
OI Rull, Anna/0000-0002-8907-7754; Alonso-Villaverde,
   Carlos/0000-0001-8278-8388; Aragones, Gerard/0000-0001-8657-5726;
   Beltran-Debon, Raul/0000-0001-9691-1906; Joven,
   Jorge/0000-0003-2749-4541
FU Instituto de Salud Carlos III [FIS 02/0430, 05/1607, 08/1175];
   Ministerio de Sanidad, Madrid, Spain; Generalitat de Catalunya
   [FI06/01054, SGR00503, 08/00064]
FX Supported by grants from the Instituto de Salud Carlos III (FIS 02/0430,
   05/1607, 08/1175), Ministerio de Sanidad, Madrid, Spain. G A, AR, and RB
   are recipients of post-graduate fellowships from the Generalitat de
   Catalunya (FI06/01054, SGR00503, and 08/00064 respectively). Editorial
   assistance was provided by Dr. Peter R. Turner from t-SciMed (Reus,
   Spain).
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U1 0
U2 3
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1476-511X
J9 LIPIDS HEALTH DIS
JI Lipids Health Dis.
PD MAY 14
PY 2010
VL 9
AR 46
DI 10.1186/1476-511X-9-46
PG 10
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA 603EB
UT WOS:000278190200001
PM 20470383
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Bai, JH
   Meng, LY
   Tang, L
   Zhen, RF
   Xue, LP
   Li, F
   Zhao, RH
   Liang, ZQ
AF Bai, Jihong
   Meng, Liangyan
   Tang, Ling
   Zhen, Ruifeng
   Xue, Liping
   Li, Fan
   Zhao, Rihong
   Liang, Zhiqing
TI Artesunate ameliorates non-alcoholic fatty liver disease cells by
   regulating the inflammatory cytokines and oxidative stress in
   vitro
SO INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
LA English
DT Article
DE Artesunate; nonalcoholic fatty liver disease; TLR4/PI3K/Akt signal
   pathway; inflammation; oxidative stress
ID STEATOHEPATITIS; MALARIA; PATHWAY; MYD88; DRUG; DIET
AB Recently, nonalcoholic fatty liver disease has become the most common cause of chronic liver disease with the increasing prevalence of obesity, diabetes, and the metabolic syndrome in the general population. Nevertheless, it still has no obvious treatment mechanism so far. Artesunate is the water soluble derivatives of artemisinin which shows high activity against both drug-resistant and drug-sensitive of malaria. In the present study, we employed artesunate to assess whether it could improve nonalcoholic fatty liver disease. The 20 mu g/mL oleic acid was employed as a treating reagent to induce steatosis, this was used for building a hepatocyte LO-2 nonalcoholic fatty liver disease cell model, which could mimic the histological features and pathological symptom. Therefore, this model was treated with different concentrations of artesunate. The total content of triglyceride (TG), alanine aminotransferase, aspartate amino transferase, alkaline phosphatase and tumor necrosis factor (TNF-alpha), interleukin-6 (IL6), interleukin-10 (IL-10) and interleukin-18 (IL-18) were determined by Elisa, and immunoflurescence and Western blot were employed for further confirmation. Optical microscopy, Western blot, Elisa technique, immunoflurescence and dichlorofluorescin diacetate (DCFH-DA) assays suggested that artesunate was able to improve nonalcoholic fatty liver disease by regulating the downstream inflammatory cytokines (TNF-alpha, IL-6, IL-8 and IL-18) and oxidative stress which were associated with TLR4/PI3K/Akt pathway. These results demonstrated that artesunate could be a potential therapeutic strategy for preventing the progression and development of nonalcoholic fatty liver disease cells. This report is conductive to deepening the understanding of nonalcoholic fatty liver disease mechanism and provides theoretical basis for clinical application of artesunate in treating nonalcoholic fatty liver disease.
C1 [Bai, Jihong] Guilin Med Univ, Affiliated Hosp, Dept Grad Educ, Guilin, Guangxi, Peoples R China.
   [Meng, Liangyan; Liang, Zhiqing] Guilin Med Univ, Affiliated Hosp, Dept Infect Dis, 15 Lequn Rd, Guilin, Guangxi, Peoples R China.
   [Tang, Ling; Zhen, Ruifeng; Xue, Liping] Guilin Med Univ, Affiliated Hosp, Dept Gerontol, Guilin, Guangxi, Peoples R China.
   [Li, Fan] Guilin Med Univ, Affiliated Hosp, Dept Pharmaceut, Guilin, Guangxi, Peoples R China.
   [Zhao, Rihong] Guilin Med Univ, Affiliated Hosp, Dept Neonatol, Guilin, Guangxi, Peoples R China.
C3 Guilin Medical University; Guilin Medical University; Guilin Medical
   University; Guilin Medical University; Guilin Medical University
RP Liang, ZQ (corresponding author), Guilin Med Univ, Affiliated Hosp, Dept Infect Dis, 15 Lequn Rd, Guilin, Guangxi, Peoples R China.; Zhao, RH (corresponding author), Guilin Med Univ, Affiliated Hosp, Dept Neonatol, Guilin, Guangxi, Peoples R China.
EM zhrhemail@163.com; liangzhiqing2929@163.com
FU National Natural Science Foundation of China [81-260078]; Guangxi
   Natural Science Foundation [2012GXNSFAA276038, 2014 GXNSFAA118152];
   Guangxi medical self-raised funds plan project [Z2015367]
FX This research was supported by the National Natural Science Foundation
   of China (No. 81-260078); Guangxi Natural Science Foundation under Grant
   (2012GXNSFAA276038, 2014 GXNSFAA118152); Guangxi medical self-raised
   funds plan project (Z2015367).
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NR 23
TC 3
Z9 3
U1 0
U2 6
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 1940-5901
J9 INT J CLIN EXP MED
JI Int. J. Clin. Exp. Med.
PY 2017
VL 10
IS 12
BP 16064
EP 16074
PG 11
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA FR6XO
UT WOS:000419211000024
DA 2025-06-11
ER

PT J
AU Coss, E
   Watt, KDS
   Pedersen, R
   Dierkhising, R
   Heimbach, JK
   Charlton, MR
AF Coss, Elizabeth
   Watt, Kymberly D. S.
   Pedersen, Rachel
   Dierkhising, Ross
   Heimbach, Julie K.
   Charlton, Michael R.
TI Predictors of Cardiovascular Events After Liver Transplantation: A Role
   for Pretransplant Serum Troponin Levels
SO LIVER TRANSPLANTATION
LA English
DT Article
ID CORONARY-ARTERY-DISEASE; C-REACTIVE PROTEIN; DOBUTAMINE STRESS
   ECHOCARDIOGRAPHY; ACUTE MYOCARDIAL-INFARCTION; CIRRHOTIC CARDIOMYOPATHY;
   METABOLIC SYNDROME; MORTALITY; SURVIVAL; FAILURE; INJURY
AB Cardiovascular complications are major causes of morbidity and mortality after liver transplantation. Identifying candidates at highest risk of postoperative complications is a cornerstone of optimizing outcomes and utility. Using traditional cardiac risk factors in addition to C-reactive protein (CRP) levels, troponin levels, and echocardiographic parameters before transplantation, we sought to define cardiac risk so that we could predict cardiovascular events after transplantation. From December 1998 to December 2001, 230 adult patients who underwent liver transplantation with a median follow-up of 8.2 years were studied. The risk factors for cardiac disease were as follows: male gender with a mean age of approximately 50 years (57%), smoking history (60%), diabetes (23%), hypertension (19%), elevated troponin (25%), elevated CRP (25%), and preexisting cardiac disease (16%). Fifty-nine cardiac events occurred over 8.2 years. Risk factors (univariate analysis) for first cardiac events included age in decades [hazard ratio (HR) = 1.31, P = 0.047], diabetes (HR = 2.20, P = 0.004), prior cardiovascular disease (HR = 4.77, P < 0.0001), a troponin I level > 0.07 ng/mL (HR = 2.00, P = 0.023), left ventricular hypertrophy (HR = 2.06, P = 0.047), stress wall abnormalities (HR = 2.25, P = 0.018), and ischemia on stress imaging (HR = 2.89, P = 0.015). Multivariate analysis confirmed age, diabetes, a troponin I level > 0.07, and prior cardiac disease as independent risk factors for posttransplant cardiac events. In conclusion, pretransplant elevated troponin levels, diabetes, and a history of cardiovascular disease, alone or in combination, are strongly associated with the occurrence of posttransplant cardiovascular events. Liver Transpl 17:23-31, 2011. (C) 2011 AASLD. Received April 9, 2010; accepted July 15, 2010.
C1 [Watt, Kymberly D. S.; Charlton, Michael R.] Mayo Clin & Mayo Fdn, Div Gastroenterol & Hepatol, Rochester, MN 55905 USA.
   [Coss, Elizabeth; Watt, Kymberly D. S.; Pedersen, Rachel; Dierkhising, Ross; Heimbach, Julie K.; Charlton, Michael R.] Mayo Clin & Mayo Fdn, Mayo Clin Transplant Ctr, Rochester, MN 55905 USA.
   [Coss, Elizabeth; Watt, Kymberly D. S.; Charlton, Michael R.] Mayo Clin & Mayo Fdn, Dept Internal Med, Rochester, MN 55905 USA.
   [Pedersen, Rachel; Dierkhising, Ross] Mayo Clin & Mayo Fdn, Div Biomed Stat & Informat, Rochester, MN 55905 USA.
   [Heimbach, Julie K.] Mayo Clin & Mayo Fdn, Dept Surg, Rochester, MN 55905 USA.
C3 Mayo Clinic; Mayo Clinic; Mayo Clinic; Mayo Clinic; Mayo Clinic
RP Watt, KDS (corresponding author), Mayo Clin & Mayo Fdn, Div Gastroenterol & Hepatol, CH 10,200 1st St SW, Rochester, MN 55905 USA.
EM watt.kymberly@mayo.edu
RI Watt, Kymberly/D-5359-2017
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NR 35
TC 77
Z9 78
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1527-6465
EI 1527-6473
J9 LIVER TRANSPLANT
JI Liver Transplant.
PD JAN
PY 2011
VL 17
IS 1
BP 23
EP 31
DI 10.1002/lt.22140
PG 9
WC Gastroenterology & Hepatology; Surgery; Transplantation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery; Transplantation
GA 711GW
UT WOS:000286576100004
PM 21254341
OA Bronze
DA 2025-06-11
ER

PT J
AU Sugita, M
   Sugita, H
   Kaneki, M
AF Sugita, M
   Sugita, H
   Kaneki, M
TI Increased insulin receptor substrate 1 serine phosphorylation and
   stress-activated protein kinase/c-Jun N-terminal kinase
   activation associated with vascular insulin resistance in spontaneously
   hypertensive rats
SO HYPERTENSION
LA English
DT Article
DE insulin resistance; rats, spontaneously hypertensive; aorta;
   phosphorylation; kinase; signal transduction
ID INTIMA-MEDIA THICKNESS; HOMEOSTASIS MODEL ASSESSMENT; METABOLIC
   SYNDROME; ANGIOTENSIN-II; NITRIC-OXIDE; RISK-FACTOR; IN-VIVO;
   CARDIOVASCULAR-DISEASE; SIGNALING PATHWAYS; OXIDATIVE STRESS
AB Insulin resistance is associated with cardiovascular disease. Impaired insulin receptor substrate (IRS)-mediated signal transduction is a major contributor to insulin resistance. Recently, IRS-1 phosphorylation at serine 307 by stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) has been highlighted as a molecular event that causes insulin resistance. We investigated IRS-1-mediated insulin signaling, IRS-1 phosphorylation at serine 307, and SAPK/JNK activation status in the aorta of spontaneously hypertensive rats (SHR) by immunoprecipitation and immunoblotting. Insulin-stimulated tyrosine phosphorylation of insulin receptor and IRS-1 in SHR was decreased to 55% (P < 0.01) and 40% (P < 0.01) of the levels in Wistar-Kyoto rats (WKY), respectively. Insulin-stimulated IRS-1-associated phosphatidylinositol 3-kinase activation in SHR was reduced to 28% of the level in WKY (P < 0.0001). Immunoblot analysis revealed that phosphorylated IRS-1 at serine 307 in SHR was increased to 261% (P < 0.001) of the level in WKY. Phosphorylated ( activated) SAPK/JNK in SHR was increased to 223% of the level in WKY (P < 0.01). Serine-phosphorylated IRS-1 that was immunoprecipitated from the aorta of SHR was capable of inhibiting in vitro tyrosine phosphorylation by recombinant insulin receptor compared with WKY-derived IRS-1. These findings demonstrate that insulin resistance in the aorta of SHR was associated with elevated IRS-1 phosphorylation at serine 307 and increased SAPK/JNK activation. The present study suggests that increased SAPK/JNK activation may play an important role in the pathogenesis of vascular insulin resistance via inhibitory serine phosphorylation of IRS-1.
C1 Harvard Univ, Sch Med, Massachusetts Gen Hosp, Dept Anesthesia & Crit Care, Charlestown, MA 02129 USA.
C3 Harvard University; Harvard University Medical Affiliates; Massachusetts
   General Hospital
RP Harvard Univ, Sch Med, Massachusetts Gen Hosp, Dept Anesthesia & Crit Care, 149 13th St,Room 6604, Charlestown, MA 02129 USA.
EM mkaneki@partners.org
FU NIDDK NIH HHS [R01DK058127] Funding Source: Medline
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NR 51
TC 26
Z9 29
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0194-911X
EI 1524-4563
J9 HYPERTENSION
JI Hypertension
PD OCT
PY 2004
VL 44
IS 4
BP 484
EP 489
DI 10.1161/01.HYP.0000140778.53811.20
PG 6
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 856PB
UT WOS:000224056000023
PM 15302844
DA 2025-06-11
ER

PT J
AU Chang, CH
   Weng, HH
   Lin, YC
   Lin, CN
   Huang, TJ
   Chen, MY
AF Chang, Chia-Hao
   Weng, Hsu-Huei
   Lin, Yu-Chih
   Lin, Chia-Ni
   Huang, Tung-Jung
   Chen, Mei-Yen
TI Association between serum carcinoembryonic antigen and cardiometabolic
   risks: Implication for cardiometabolic prevention
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Article
DE tumor marker; carcinoembryonic antigen (CEA); oxidative stress;
   1hydroxypyrene (1-OHP); malondialdehyde (MDA); cardiometabolic diseases
   (CMDs); unhealthy lifestyle
ID CANCER
AB BackgroundSerum carcinoembryonic antigen (CEA) is a biomarker commonly used to detect colorectal cancer. CEA levels are affected by many factors, including cardiometabolic diseases, such as cardiovascular diseases (CVDs) and diabetes. Cardiometabolic diseases and cancer share a similar pathological inflammatory pathway, which correlates with an unhealthy lifestyle. Hence, establishing an adequate CEA cut-off value might be a valuable reference for developing precision healthcare programs for cardiometabolic disease prevention. This study aimed to investigate the association between cardiometabolic risks and serum CEA and the underlying factors. MethodsA community-based, cross-sectional study was conducted between March and December 2021 on the western coast of Taiwan. Lifestyle data were assessed using a structured questionnaire. The cardiometabolic biomarkers, serum CEA, urine malondialdehyde, and 1-hydroxypyrene were quantified by the central laboratory of the collaborating hospital. Chi-square and binary multivariable logistic regression implemented in R version 4.0.2 were used to identify factors defining the risk of high serum CEA levels. ResultsA total of 6,295 adult residents without cancer-related diseases completed the study. The mean age was 48.6 (SD = 16.4) years, 56% were female, 32% had metabolic syndrome, and 23% and 10% had CVDs and diabetes, respectively. Multivariate logistic regression showed that age >= 65 years, male sex, alcohol consumption, smoking, infrequent use of dental floss, fewer remaining teeth, CVDs, diabetes, and oxidative stress were significantly associated with serum CEA >= 3 ng/mL. The discriminatory performance of the area under the receiver operating characteristic curve was 0.75 (0.73-0.76), showing that this model was suitable for distinguishing high CEA levels. ConclusionOur findings highlight the importance of understanding cardiometabolic diseases, unhealthy lifestyles, and oxidative stress, which contribute to high serum CEA. This study demonstrates that CEA, a well-known tumor marker, can help the early detection and prevention of cardiometabolic diseases via personalized lifestyle modification.
C1 [Chang, Chia-Hao; Weng, Hsu-Huei; Huang, Tung-Jung; Chen, Mei-Yen] Chang Gung Univ Sci & Technol, Dept Nursing, Chiayi, Taiwan.
   [Weng, Hsu-Huei] Chang Gung Mem Hosp, Dept Diagnost Radiol, Chiayi, Taiwan.
   [Lin, Yu-Chih] Chang Gung Mem Hosp, Dept Family Med, Mailiao Township, Yunlin, Taiwan.
   [Lin, Chia-Ni] Chang Gung Mem Hosp, Dept Lab Med, Linkou, Taiwan.
   [Lin, Chia-Ni] Chang Gung Univ, Dept Med Biotechnol & Lab Sci, Taoyuan, Taiwan.
   [Huang, Tung-Jung] Chang Gung Mem Hosp, Dept Pulm & Crit Care, Mailiao Township, Yunlin, Taiwan.
   [Chen, Mei-Yen] Chang Gung Univ, Sch Nursing, Taoyuan, Taiwan.
   [Chen, Mei-Yen] Chang Gung Mem Hosp, Dept Cardiol, Chiayi, Taiwan.
C3 Chang Gung University of Science & Technology; Chang Gung Memorial
   Hospital; Chang Gung Memorial Hospital; Chang Gung Memorial Hospital;
   Chang Gung University; Chang Gung Memorial Hospital; Chang Gung
   University; Chang Gung Memorial Hospital
RP Chen, MY (corresponding author), Chang Gung Univ Sci & Technol, Dept Nursing, Chiayi, Taiwan.; Chen, MY (corresponding author), Chang Gung Univ, Sch Nursing, Taoyuan, Taiwan.; Chen, MY (corresponding author), Chang Gung Mem Hosp, Dept Cardiol, Chiayi, Taiwan.
EM meiyen@mail.cgust.edu.tw
RI Chang, Chia-Hao/HSF-6661-2023; Weng, Hsu-Huei/N-8329-2014
OI Lin, Yu-Chih/0000-0002-1190-406X; Weng, Hsu-Huei/0000-0002-2020-8912
CR Ahmad S, 2018, JAMA NETW OPEN, V1, DOI 10.1001/jamanetworkopen.2018.5708
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   World Health Organization, CARDIOVASC DIS
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NR 35
TC 2
Z9 3
U1 1
U2 4
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD FEB 23
PY 2023
VL 14
AR 1113178
DI 10.3389/fendo.2023.1113178
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 9R4GR
UT WOS:000945614000001
PM 36909325
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Jeong, MJ
   Kim, SR
   Jung, UJ
AF Jeong, Mi Ji
   Kim, Sang Ryong
   Jung, Un Ju
TI Schizandrin A supplementation improves nonalcoholic fatty liver disease
   in mice fed a high-fat and high-cholesterol diet
SO NUTRITION RESEARCH
LA English
DT Article
DE Schizandrin A; Nonalcohol fatty liver disease; Lipid metabolism;
   Antioxidant activity; High-fat and high-cholesterol diet
ID OXIDATIVE STRESS; METABOLIC SYNDROME; ACID HOMEOSTASIS; GENE-EXPRESSION;
   ABCA1; INHIBITION; CHINENSIS; ASSAY; 7-ALPHA-HYDROXYLASE; PATHOGENESIS
AB We hypothesized that schizandrin (SCH) A, a lignan found in the fruits of the Schisandra genus, would exert protective effects against high-fat and high-cholesterol (HFHC) diet-induced nonalcoholic fatty liver disease (NAFLD) via regulation of lipid metabolism and oxidative stress. To test our hypothesis, male C57BL/6J mice were fed an HFHC diet with or without SCH A for 15 weeks. There were no significant differences in food intake, body weight, fat mass, and plasma total cholesterol level between the 2 groups. However, supplementation of SCH A significantly decreased levels of plasma free fatty acid and triglyceride, whereas plasma high-density lipoprotein cholesterol level was increased in the SCH A-supplemented mice. Moreover, hepatic free fatty acid, triglyceride, and cholesterol content, as well as hepatic lipid droplet accumulation, were markedly lower in the SCH A group in contrast to the control group. Activity of hepatic enzymes involved in fatty acid and triglyceride synthesis was significantly decreased by SCH A supplementation, whereas SCH A markedly increased hepatic beta-oxidation and fatty acid oxidation-related gene expression as well as fecal excretion of free fatty acid and triglyceride. SCH A also significantly increased expression of genes involved in cholesterol homeostasis (biliary cholesterol excretion and cholesterol efflux to high-density lipoprotein) in the liver. Moreover, SCH A significantly decreased hepatic lipid peroxidation, which was accompanied by increased hepatic antioxidant enzymes activity. These results suggest that SCH A could alleviate HFHC diet-induced NAFLD by regulating hepatic lipid metabolism and oxidative stress as well as fecal lipid excretion. (C) 2019 Elsevier Inc. All rights reserved.
C1 [Jeong, Mi Ji; Jung, Un Ju] Pukyong Natl Univ, Dept Food Sci & Nutr, 45 Yongso Ro, Busan 48513, South Korea.
   [Kim, Sang Ryong] Kyungpook Natl Univ, Sch Life Sci, BK21 Plus KNU Creat BioRes Grp, 1370 San Kyuk Dong, Daegu 41566, South Korea.
C3 Pukyong National University; Kyungpook National University (KNU)
RP Jung, UJ (corresponding author), Pukyong Natl Univ, Dept Food Sci & Nutr, 45 Yongso Ro, Busan 48513, South Korea.
EM jungunju@naver.com
OI Kim, PhD, Sang Ryong/0000-0003-0299-1613
FU National Research Foundation of Korea - Korean government
   [NRF-2014R1A1A4A01007858, 2016R1D1A3B03931424]
FX This work was supported by grants from the National Research Foundation
   of Korea funded by the Korean government (NRF-2014R1A1A4A01007858 and
   2016R1D1A3B03931424). None of the authors have any conflicts of interest
   to declare.
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NR 60
TC 23
Z9 24
U1 0
U2 26
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0271-5317
EI 1879-0739
J9 NUTR RES
JI Nutr. Res.
PD APR
PY 2019
VL 64
BP 64
EP 71
DI 10.1016/j.nutres.2019.01.001
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA HT3TN
UT WOS:000464486200007
PM 30802724
DA 2025-06-11
ER

PT J
AU Kawamoto, R
   Kohara, K
   Katoh, T
   Kusunoki, T
   Ohtsuka, N
   Abe, M
   Kumagi, T
   Miki, T
AF Kawamoto, Ryuichi
   Kohara, Katsuhiko
   Katoh, Tateaki
   Kusunoki, Tomo
   Ohtsuka, Nobuyuki
   Abe, Masanori
   Kumagi, Teru
   Miki, Tetsuro
TI Changes in oxidized low-density lipoprotein cholesterol are associated
   with changes in handgrip strength in Japanese community-dwelling persons
SO ENDOCRINE
LA English
DT Article
DE Oxidized LDL-cholesterol; MDL-LDL; Handgrip strength; Nordic walking
   exercise
ID NORDIC WALKING; GRIP STRENGTH; METABOLIC SYNDROME; OXIDATIVE STRESS;
   BODY-COMPOSITION; OLD-AGE; SARCOPENIA; MORTALITY; EXERCISE; MUSCLE
AB Nordic walking (NW), characterized by the use of two walking poles, has positive effects on several muscle groups. Muscle strength and mass decrease with age, and recently, this decrease is defined as sarcopenia. Sarcopenia may be triggered by oxidative stress. We investigated whether changes in the oxidative stress marker, malondialdehyde-modified low-density lipoprotein (MDA-LDL)/LDLcholesterol (LDL-C) ratio are associated with change in handgrip strength (HGS), which is a useful indicator of sarcopenia, by a 12-week NW exercise among Japanese community-dwelling persons. The present study included 65 women aged 67 +/- 7 years and 9 men aged 71 +/- 8 years from a rural village. NW exercise of 120 min per week was performed for 12 weeks. Before and at the end of the 12-week intervention, various confounding factors and HGS were measured. 12-week changes in various factors were calculated by subtracting the baseline values from the 12-week values. Changes in HGS and follow-up HGS increased progressively with decreased changes in the MDA-LDL/LDL-C ratio after the 12-week walking exercise (r = -0.32, P = 0.006 and r = -0.35, P = 0.002, respectively). Multiple linear regression analysis showed that changes in HDL-C (beta = 0.26, P = 0.019) and MDALDL/LDL-C ratio (beta = -0.32, P = 0.004) were significantly and independently associated with changes in HGS. When the data were further stratified by gender, change in the MDA-LDL/LDL-C ratio was significantly and similarly associated with change in HGS in women only. These results suggest that change in MDA-LDL/LDL-C ratio may be a predictor for HGS after a 12-week NW exercise in community-dwelling persons.
C1 [Kawamoto, Ryuichi; Kusunoki, Tomo; Abe, Masanori; Kumagi, Teru] Ehime Univ, Grad Sch Med, Dept Community Med, Toon City, Ehime 7910295, Japan.
   [Kawamoto, Ryuichi; Katoh, Tateaki; Kusunoki, Tomo; Ohtsuka, Nobuyuki] Seiyo Municipal Nomura Hosp, Dept Internal Med, Seiyo City, Ehime 7971212, Japan.
   [Kohara, Katsuhiko; Katoh, Tateaki; Miki, Tetsuro] Ehime Univ, Grad Sch Med, Dept Geriatr Med, Toon City, Ehime 7910295, Japan.
C3 Ehime University; Ehime University
RP Kawamoto, R (corresponding author), Seiyo Municipal Nomura Hosp, Dept Internal Med, 9-53 Nomura,Nomura Cho, Seiyo City, Ehime 7971212, Japan.
EM rykawamo@m.ehime-u.ac.jp; koharak@m.ehime-u.ac.jp;
   takeaki.katoh@gmail.com; kusunoki.tomo.mm@ehime-u.ac.jp;
   ohtsukan@hotmail.com; masaben@m.ehime-u.ac.jp; terukuma@m.ehime-u.ac.jp;
   tmiki@m.ehime-u.ac.jp
RI Kumagi, Teru/AAS-7427-2021
OI Kumagi, Teru/0000-0002-2292-7750
FU Foundation for Development of Community; Grants-in-Aid for Scientific
   Research [25670353] Funding Source: KAKEN
FX This work was supported in part by a grant-in-aid for Scientific
   Research from the Foundation for Development of Community (2013).
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NR 28
TC 11
Z9 12
U1 0
U2 10
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1355-008X
EI 1559-0100
J9 ENDOCRINE
JI Endocrine
PD APR
PY 2015
VL 48
IS 3
BP 871
EP 877
DI 10.1007/s12020-014-0360-5
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA CE2QT
UT WOS:000351661100018
PM 25064380
DA 2025-06-11
ER

PT J
AU Christodoulou, MI
   Tchoumtchoua, J
   Skaltsounis, AL
   Scorilas, A
   Halabalaki, M
AF Christodoulou, Maria-Ioanna
   Tchoumtchoua, Job
   Skaltsounis, Alexios-Leandros
   Scorilas, Andreas
   Halabalaki, Maria
TI Natural Alkaloids Intervening the Insulin Pathway: New Hopes for
   Anti-Diabetic Agents?
SO CURRENT MEDICINAL CHEMISTRY
LA English
DT Review
DE Alkaloids; natural products; diabetes mellitus (DM); insulin-signaling
   pathway; insulin resistance; inflammation; oxidative stress
ID HIGH-FAT DIET; ACTIVATED PROTEIN-KINASE; NRF2 NUCLEAR TRANSLOCATION;
   BETA-CELL; OXIDATIVE STRESS; METABOLIC SYNDROME; INDUCED OBESITY;
   ADIPOSE-TISSUE; GLUCOSE-UPTAKE; ANTIHYPERGLYCEMIC ACTIVITY
AB Background: Accumulating experimental data supports the capacity of natural compounds to intervene in complicated molecular pathways underlying the pathogenesis of certain human morbidities. Among them, diabetes is now a world's epidemic associated with increased risk of death; thus, the detection of novel anti-diabetic agents and/or adjuvants is of vital importance. Alkaloids represent a diverse group of natural products with a range of therapeutic properties; during the last 20 years, published research on their anti-diabetic capacity has been tremendously increased.
   Purpose: To discuss current concepts on the anti-diabetic impact of certain alkaloids, with special reference to their molecular targets throughout the insulin-signaling pathway. Methodology: Upon in-depth search in the SCOPUS and PUBMED databases, the literature on alkaloids with insulin secretion/sensitization properties was critically reviewed.
   Results: In-vitro and in-vivo evidence supports the effect of berberine, trigonelline, piperine, oxymatrine, vindoneline, evodiamine and neferine on insulin-signaling and related cascades in beta-cells, myocytes, adipocytes, hepatocytes and other cells. Associated receptors, kinases, hormones and cytokines, are affected in terms of gene transcription, protein expression, activity and/or phosphorylation. Pathophysiological processes associated with insulin resistance, beta-cell failure, oxidative stress and inflammation, as well as clinical phenotype are also influenced.
   Discussion: Growing evidence suggests the ability of specific alkaloids to intervene in the insulin-signal transduction pathway, reverse molecular defects resulting in insulin resistance and glucose intolerance and improve disease complications, in-vitro and in-vivo. Future indepth molecular studies are expected to elucidate their exact mechanism of action, while large clinical trials are urgently needed to assess their potential as anti-diabetic agents.
C1 [Christodoulou, Maria-Ioanna; Scorilas, Andreas] Natl & Kapodistrian Univ Athens, Fac Biol, Dept Biochem & Mol Biol, Athens 15771, Greece.
   [Tchoumtchoua, Job; Skaltsounis, Alexios-Leandros; Halabalaki, Maria] Natl & Kapodistrian Univ Athens, Fac Pharm, Dept Pharmacognosy & Nat Prod Chem, Athens 15771, Greece.
C3 National & Kapodistrian University of Athens; National & Kapodistrian
   University of Athens
RP Christodoulou, MI (corresponding author), Natl & Kapodistrian Univ Athens, Fac Biol, Dept Biochem & Mol Biol, Athens 15771, Greece.
EM mchrist@biol.uoa.gr
RI skaltsounis, alexios/AAE-9617-2019; Halabalaki, Maria/AAD-2127-2020
OI Christodoulou, Maria-Ioanna (Marianna)/0000-0003-1659-4993;
   Tchoumtchoua, Job/0000-0002-5379-7020
FU Commission of the European Community through the INsPiRE project
   [284460]
FX This work was financially supported by the Commission of the European
   Community through the INsPiRE project (EU-FP7-REGPOT-2011-1, proposal
   284460).
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NR 176
TC 29
Z9 32
U1 1
U2 46
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 0929-8673
EI 1875-533X
J9 CURR MED CHEM
JI Curr. Med. Chem.
PY 2019
VL 26
IS 32
BP 5982
EP 6015
DI 10.2174/0929867325666180430152618
PG 34
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Pharmacology &
   Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
GA JO8IX
UT WOS:000497819700006
PM 29714135
DA 2025-06-11
ER

PT J
AU Aranda, N
   Fernandez-Cao, JC
   Tous, M
   Arija, V
AF Aranda, Nuria
   Candido Fernandez-Cao, Jose
   Tous, Monica
   Arija, Victoria
TI Increased iron levels and lipid peroxidation in a Mediterranean
   population of Spain
SO EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
LA English
DT Article
DE Elevated iron levels; lipid peroxidation; oxidative stress; oxidized
   low-density lipoprotein; oxLDL/LDL-cholesterol ratio
ID LOW-DENSITY-LIPOPROTEIN; CORONARY-HEART-DISEASE; OXIDATIVE DNA-DAMAGE;
   BODY IRON; METABOLIC SYNDROME; SERUM FERRITIN; OXIDIZED LDL;
   HEALTHY-MEN; STRESS; RISK
AB Background Many chronic diseases are adversely affected by elevated iron levels. It has been speculated that this relationship is mediated by increased oxidative stress, due to the ability of iron to generate reactive oxygen species. The aim of this study was to assess the relationship between elevated iron levels and lipid peroxidation in Caucasian adults residing in the north-eastern Mediterranean region of Spain.
   Materials and methods This cross-sectional case-control study included 300 subjects: 150 adults displaying elevated iron levels (cases) selected from a representative sample of our general population and 150 age-and sex-matched adults exhibiting normal iron levels (controls). Dietary assessment (3-day food records), iron biomarkers (serum iron, ferritin and transferrin saturation) and lipid profile were determined. Elevated iron levels were defined by high serum ferritin (SF>110 mu g/L in women and>200 mu g/L in men) and/or transferrin saturation (TS)>45%. Oxidized low-density lipoprotein (oxLDL) plasma levels were measured, and oxLDL/LDL-cholesterol ratio was calculated to estimate lipid peroxidation. Multiple linear regression (MLR) models were applied.
   Results Individuals with elevated serum iron levels showed increased oxLDL/LDL ratio, but not oxLDL levels, compared to control subjects (20.92 +/- 4.89 U/mmol vs. 19.72 +/- 3.573 U/mmol, P = 0.028). These results were further confirmed by the regression models adjusted for demographic characteristics, diet, lipid profile and inflammation. Importantly, higher serum levels of triglycerides, LDL-cholesterol and lower intake of Vitamin E increased lipid peroxidation.
   Conclusions In our general population, we have observed that higher circulating levels of iron, measured by serum ferritin and/or TS, increased lipid peroxidation (measured by oxLDL/LDL ratio).
C1 [Aranda, Nuria; Candido Fernandez-Cao, Jose; Tous, Monica; Arija, Victoria] Univ Rovira & Virgili, Res Grp Nutr & Mental Hlth NUTRISAM, Fac Med & Hlth Sci, Nutr & Publ Hlth Unit,IISPV, Reus, Spain.
   [Arija, Victoria] Inst Univ Invest Atencio Primaria Jordi Gol, Unitat Suport Recerca Tarragona Reus, Tarragona, Spain.
C3 Universitat Rovira i Virgili; Institut d'Investigacio Sanitaria Pere
   Virgili (IISPV)
RP Arija, V (corresponding author), Univ Rovira & Virgili, Nutr & Publ Hlth Unit, Fac Med & Hlth Sci, C St Llorenc 21, E-43201 Reus, Spain.
EM victoria.arija@urv.cat
RI Fernandez-Cao, Jose Candido/N-1509-2018; Aranda, Nuria/D-1942-2016
OI Fernandez-Cao, Jose Candido/0000-0002-1697-3443; Aranda,
   Nuria/0000-0001-9708-747X; Arija, Victoria/0000-0002-1758-0975; Tous,
   Monica/0000-0003-0104-9511
FU Instituto de Salud Carlos III, Fondo de Investigacion Sanitaria,
   Ministerio de Sanidad y Consumo, Madrid, Spain [PI021131]
FX This study was supported by a grant from the Instituto de Salud Carlos
   III, Fondo de Investigacion Sanitaria, Ministerio de Sanidad y Consumo,
   Madrid, Spain (PI021131).
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NR 41
TC 17
Z9 17
U1 0
U2 8
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0014-2972
EI 1365-2362
J9 EUR J CLIN INVEST
JI Eur. J. Clin. Invest.
PD JUN
PY 2016
VL 46
IS 6
BP 520
EP 526
DI 10.1111/eci.12625
PG 7
WC Medicine, General & Internal; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Research & Experimental Medicine
GA DR1MJ
UT WOS:000379669300003
PM 26999720
DA 2025-06-11
ER

PT J
AU Takada, S
   Hirabayashi, K
   Kinugawa, S
   Yokota, T
   Matsushima, S
   Suga, T
   Kadoguchi, T
   Fukushima, A
   Homma, T
   Mizushima, W
   Masaki, Y
   Furihata, T
   Katsuyama, R
   Okita, K
   Tsutsui, H
AF Takada, Shingo
   Hirabayashi, Kagami
   Kinugawa, Shintaro
   Yokota, Takashi
   Matsushima, Shouji
   Suga, Tadashi
   Kadoguchi, Tomoyasu
   Fukushima, Arata
   Homma, Tsuneaki
   Mizushima, Wataru
   Masaki, Yoshihiro
   Furihata, Takaaki
   Katsuyama, Ryoichi
   Okita, Koichi
   Tsutsui, Hiroyuki
TI Pioglitazone ameliorates the lowered exercise capacity and impaired
   mitochondrial function of the skeletal muscle in type 2 diabetic mice
SO EUROPEAN JOURNAL OF PHARMACOLOGY
LA English
DT Article
DE Insulin resistance; Diabetes; Mitochondria; Muscle; Oxidative stress
ID HIGH-FAT DIET; INDUCED INSULIN-RESISTANCE; LOWER AEROBIC CAPACITY;
   OXIDATIVE STRESS; METABOLIC SYNDROME; NAD(P)H OXIDASE; ADIPONECTIN;
   IMPROVES; ACID; RATS
AB We have reported that exercise capacity is reduced in high fat diet (HFD)-induced diabetic mice, and that this reduction is associated with impaired mitochondrial function in skeletal muscle (SKM). However, it remains to be clarified whether the treatment of diabetes ameliorates the reduced exercise capacity. Therefore, we examined whether an insulin sensitizing drug, pioglitazone, could improve exercise capacity in HFD mice. C57BL/6J mice were fed a normal diet (ND) or HFD, then treated with or without pioglitazone (3 mg/kg/day) to yield the following 4 groups: ND+vehicle, ND+pioglitazone, FLED I vehicle, and HFD+pioglitazone (n=10 each). After 8 weeks, body weight, plasma glucose, and insulin in the HFD+vehicle were significantly increased compared to the ND I vehicle group. Pioglitazone normalized the insulin levels in RED fed mice, but did not affect the body weight or plasma glucose. Exercise capacity determined by treadmill tests was significantly reduced in the HFD+vehicle, and this reduction was almost completely ameliorated in HFD+pioglitazone mice. ADP dependent mitochondrial respiration, complex l and Ill activities, and citrate synthase activity were significantly decreased in the SKM of the HFD+vehicle animals, and these decreases were also attenuated by pioglitazone. NAD(P)H oxidase activity was significantly increased in the HFD+vehicle compared with the ND+vehicle, and this increase was ameliorated in HFD+pioglitazone mice. Pioglitazone improved the exercise capacity in diabetic mice, which was due to the improvement in mitochondria! function and attenuation of oxidative stress in the SKM. Our data suggest that pioglitazone may be useful as an agent for the treatment of diabetes mellitus. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Takada, Shingo; Hirabayashi, Kagami; Kinugawa, Shintaro; Yokota, Takashi; Matsushima, Shouji; Kadoguchi, Tomoyasu; Fukushima, Arata; Homma, Tsuneaki; Mizushima, Wataru; Masaki, Yoshihiro; Furihata, Takaaki; Katsuyama, Ryoichi; Tsutsui, Hiroyuki] Hokkaido Univ, Grad Sch Med, Dept Cardiovasc Med, Kita Ku, Sapporo, Hokkaido 0608638, Japan.
   [Suga, Tadashi] Ritsumeikan Univ, Fac Sport & Hlth Sci, Kusatsu, Shiga, Japan.
   [Okita, Koichi] Hokusho Univ, Dept Sport Educ, Ebetsu, Hokkaido, Japan.
C3 Hokkaido University; Ritsumeikan University
RP Kinugawa, S (corresponding author), Hokkaido Univ, Grad Sch Med, Dept Cardiovasc Med, Kita Ku, Kita 15,Nishi 7, Sapporo, Hokkaido 0608638, Japan.
EM tuckahoe@med.hokudai.ac.jp
RI Kinugawa, Shintaro/E-1268-2012; matsushima, shouji/IUO-9529-2023
OI Kadoguchi, Tomoyasu/0000-0001-6336-5160
FU Ministry of Education, Science, and Culture [26750331, 26350879,
   25670378, 24390192, 25893005, 24003762, 23500784]; Takeda Pharmaceutical
   Co. Ltd.; Grants-in-Aid for Scientific Research [25893005, 26750331,
   24390192, 25670378, 26350879, 23500784] Funding Source: KAKEN
FX This study was supported by grants from the Ministry of Education,
   Science, and Culture (26750331, 26350879, 25670378, 24390192, 25893005,
   24003762 and 23500784) and from Takeda Pharmaceutical Co. Ltd.
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NR 37
TC 24
Z9 25
U1 0
U2 20
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0014-2999
EI 1879-0712
J9 EUR J PHARMACOL
JI Eur. J. Pharmacol.
PD OCT 5
PY 2014
VL 740
BP 690
EP 696
DI 10.1016/j.ejphar.2014.06.008
PG 7
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA AO2OH
UT WOS:000341163700085
PM 24964389
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Burut, DFP
   Borai, A
   Livingstone, C
   Ferns, G
AF Burut, Dayangku Fatiha Pengiran
   Borai, Anwar
   Livingstone, Callum
   Ferns, Gordon
TI Serum heat shock protein 27 antigen and antibody levels appear to be
   related to the macrovascular complications associated with insulin
   resistance: a pilot study
SO CELL STRESS & CHAPERONES
LA English
DT Article
DE Hsp27; Antibodies; Glucose tolerance; Cardiovascular disease
ID IMPAIRED GLUCOSE-TOLERANCE; OXIDATIVE STRESS; CARDIOVASCULAR-DISEASE;
   DIABETES-MELLITUS; ANTIOXIDANT STATUS; METABOLIC SYNDROME; FASTING
   GLUCOSE; HEAT-SHOCK-PROTEIN-60; EXPRESSION; HSP27
AB Heat shock protein 27 (Hsp27) is over-expressed when cells are exposed to stressful conditions that include oxidative stress. Oxidative stress has been implicated in the pathogenesis of cardiovascular disease (CVD), diabetes and insulin resistance. We have investigated the concentrations of serum Hsp27 antigen and antibodies in subjects from different glycaemic categories, who either did or did not have established CVD. Serum Hsp27 antigen and antibody levels (immunoglobulins M and G (IgM and IgG)) were determined by enzyme-linked immunosorbent assays (ELISAs) in 68 individuals: 26 with normal glucose tolerance (NGT), 10 with (+) and 16 without (-) a history of CVD and 42 individuals with varying degrees of glucose intolerance (GI; 21 with and 21 without a history of CVD). Insulin sensitivity was determined in each subject using indices derived from the homeostasis model assessment of sensitivity and the insulin sensitivity index for glycaemia. Serum Hsp27 concentrations were significantly higher in GI (+CVD) subjects compared to GI (-CVD) subjects (p = 0.03), NGT (-CVD) subjects (p = 0.02) and NGT (+CVD) subjects (p = 0.04) and were positively correlated to fasting plasma glucose for all subjects (r = 0.28, p = 0.03). IgM antibody levels were significantly higher in GI (+CVD) subjects compared to NGT (-CVD) group (p = 0.02) and were inversely related to fasting insulin concentrations (r = -0.27, p = 0.04) and the 2-h insulin concentrations (r = -0.29, p = 0.03) for all subjects. Serum IgG antibody levels were higher in GI (+CVD) group compared to GI (-CVD) group (p = 0.06). In conclusion, Hsp27 and its antibody concentrations appear to relate to the presence of cardiovascular complications in patients with GI.
C1 [Burut, Dayangku Fatiha Pengiran; Borai, Anwar; Livingstone, Callum; Ferns, Gordon] Univ Surrey, Fac Hlth & Med Sci, Surrey GU2 7XH, England.
   [Livingstone, Callum; Ferns, Gordon] Royal Surrey Cty Hosp, Dept Clin Biochem, Surrey GU2 7XX, England.
C3 University of Surrey; Royal Surrey County Hospital
RP Ferns, G (corresponding author), Daphne Jackson Rd, Surrey GU2 7WG, England.
EM g.ferns@surrey.ac.uk
FU Brunei Government
FX DFPB is a recipient of a PhD studentship from the Brunei Government. We
   thank colleagues in the Clinical Investigation Unit at the Royal Surrey
   County Hospital and Peter Williams from the Statistics Department,
   University of Surrey.
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NR 46
TC 21
Z9 24
U1 0
U2 0
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1355-8145
EI 1466-1268
J9 CELL STRESS CHAPERON
JI Cell Stress Chaperones
PD JUL
PY 2010
VL 15
IS 4
BP 379
EP 386
DI 10.1007/s12192-009-0152-7
PG 8
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA 609TX
UT WOS:000278681300004
PM 19882236
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Zhou, L
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AF Zhou, Li
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   Chen, Sijing
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   Shan, Zhilei
   Cao, Benfeng
   Hu, Xueting
   Rong, Ying
   Yang, Wei
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   Tan, Aijun
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TI Diverse Associations of Plasma Selenium Concentrations and SELENOP Gene
   Polymorphism with Metabolic Syndrome and Its Components
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Article
ID OXIDATIVE STRESS; TRACE-ELEMENTS; INSULIN; CANCER; RISK;
   SELENOMETHIONINE; DISEASE; ADULTS; LIVER; SENSITIVITY
AB The relationship between selenium and metabolic syndrome (MetS) has been discussed controversially, and limited studies have examined the associations of single nucleotide polymorphisms in selenoproteins genes with MetS. Hence, to examine the associations of plasma selenium concentrations and selenoprotein P rs7579 polymorphism with MetS, a case-control study of 1279 MetS cases and 1279 sex- and age- (+/- 2 years) matched controls was conducted based on the baseline data of the Tongji-Ezhou Cohort study. Plasma selenium concentrations were measured by inductively coupled plasma mass spectrometry. MetS was defined using the definition of the Joint Interim Statement, adjusted for the Chinese population. In addition, the rs7579 polymorphism was genotyped by the Agena MassARRAY System. Plasma selenium concentrations in the MetS group were higher than in the control group (93.88 mu g/L (83.17-107.41) vs. 92.66 mu g/L (82.36-103.53), P<0.05). Compared with quartile 4 (>= 103.53 mu g/L), the multivariate-adjusted odds ratios (ORs) and 95% confidence intervals (CIs) associated with MetS were 0.79 (0.59-1.06) for quartile 1 (mu g/L), 0.75 (0.56-1.01) for quartile 2 (82.37-92.66 mu g/L), and 0.61 (0.45-0.83) for quartile 3 (92.67-103.52 mu g/L). The cubic spline analyses revealed a U-shaped association between plasma selenium and MetS, with the lowest risk at around 93.69 mu g/L. Moreover, in cubic spline analyses, plasma selenium showed U-shaped associations with central obesity and high blood pressure, positive associations with hypertriglyceridemia and hyperglycemia, and a negative association with low high-density lipoprotein cholesterol. Additionally, both the GA and GA+AA genotype carriers were associated with increased ORs of MetS comparing with the GG genotype carriers. Our findings suggested a U-shaped association between plasma selenium and MetS and diverse associations between plasma selenium and components of MetS. Furthermore, our study found that the A allele of rs7579 was associated with higher odds of MetS. Further studies are needed to confirm our findings and elucidate the underlying mechanisms.
C1 [Zhou, Li; Luo, Cheng; Yin, Jiawei; Zhu, Yalun; Li, Peiyun; Chen, Sijing; Sun, Taoping; Shan, Zhilei; Cao, Benfeng; Hu, Xueting; Yang, Wei; Li, Xiaoqin; Liu, Liegang] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Dept Nutr & Food Hyg,Hubei Key Lab Food Nutr & Sa, Wuhan, Peoples R China.
   [Zhou, Li; Luo, Cheng; Yin, Jiawei; Zhu, Yalun; Li, Peiyun; Chen, Sijing; Sun, Taoping; Shan, Zhilei; Cao, Benfeng; Hu, Xueting; Yang, Wei; Li, Xiaoqin; Liu, Liegang] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Minist Educ,Key Lab Environm & Hlth, Wuhan, Peoples R China.
   [Xie, Manling] Mayo Clin, Dept Neurol, Rochester, MN USA.
   [Shan, Zhilei] Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA.
   [Rong, Ying] Shandong Univ, Dept Nutr, Shandong Prov Hosp, Jinan, Peoples R China.
   [Tan, Aijun] Zhuhai Ctr Dis Control & Prevent, Zhuhai, Peoples R China.
C3 Huazhong University of Science & Technology; Ministry of Education -
   China; Huazhong University of Science & Technology; Mayo Clinic; Harvard
   University; Harvard T.H. Chan School of Public Health; Shandong First
   Medical University & Shandong Academy of Medical Sciences; Shandong
   University
RP Liu, LG (corresponding author), Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Dept Nutr & Food Hyg,Hubei Key Lab Food Nutr & Sa, Wuhan, Peoples R China.; Liu, LG (corresponding author), Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Minist Educ,Key Lab Environm & Hlth, Wuhan, Peoples R China.; Tan, AJ (corresponding author), Zhuhai Ctr Dis Control & Prevent, Zhuhai, Peoples R China.
EM zhcdc@sina.com; 369483610@qq.com
RI liu, bingchun/HPF-1379-2023; Yin, Jiawei/MGV-1674-2025; Li,
   Xiaoqin/W-3020-2019; , xuetinghu/GXH-7352-2022
OI Sun, Taoping/0000-0002-6412-5166; Xie, Manling/0000-0002-1747-1699
FU Major International (Regional) Joint Research Project [NSFC
   81820108027]; National Natural Science Foundation of China [81600676];
   National Key Research and Development Program of China [2017YFC1600500]
FX This work was funded by the Major International (Regional) Joint
   Research Project (NSFC 81820108027), the National Natural Science
   Foundation of China (81600676), and the National Key Research and
   Development Program of China (2017YFC1600500). We are thankful to all
   the study participants for the substantial time and effort they spent in
   contributing to our study.
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NR 44
TC 26
Z9 27
U1 0
U2 27
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PD APR 23
PY 2020
VL 2020
AR 5343014
DI 10.1155/2020/5343014
PG 11
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA LM4WH
UT WOS:000532249900004
PM 32377302
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Vegda, HS
   Patel, B
   Girdhar, GA
   Pathan, MSH
   Ahmad, R
   Haque, M
   Sinha, S
   Kumar, S
AF Vegda, Hardika S.
   Patel, Bhavin
   Girdhar, Gaurav A.
   Pathan, Mohd. Shabankhan H.
   Ahmad, Rahnuma
   Haque, Mainul
   Sinha, Susmita
   Kumar, Santosh
TI Role of Nonalcoholic Fatty Liver Disease in Periodontitis: A
   Bidirectional Relationship
SO CUREUS JOURNAL OF MEDICAL SCIENCE
LA English
DT Article
DE Categories; Dentistry nonalcoholic fatty liver disease; inflammatory
   bowel disease; low socioeconomic status; oral hygiene status; distorted
   lipid metabolism; dyslipidemia; insulin resistance; obesity; chronic
   generalized periodontitis; nafld
ID GAMMA-GLUTAMYL-TRANSFERASE; GINGIVAL CREVICULAR FLUID; HUMAN GUT
   MICROBIOME; AGGREGATIBACTER-ACTINOMYCETEMCOMITANS; INSULIN-RESISTANCE;
   DYSBIOSIS; ASSOCIATION; SERUM; STEATOHEPATITIS; HISTOPATHOLOGY
AB Nonalcoholic fatty liver disease (NAFLD) and periodontitis share common risk factors such as obesity, insulin resistance (IR), and dyslipidemia, which contribute to systemic inflammation. It has been suggested that a bidirectional relationship exists between NAFLD and periodontitis, indicating that one condition may exacerbate the other. NAFLD is characterized by excessive fat deposition in the liver and is associated with low-grade chronic inflammation. There are several risk factors for the development of NAFLD, including gender, geriatric community, race, ethnicity, poor sleep quality and sleep deprivation, physical activity, nutritional status, dysbiosis gut microbiota, increased oxidative stress, overweight, obesity, higher body mass index (BMI), IR, type 2 diabetes mellitus (T2DM), metabolic syndrome (MetS), dyslipidemia (hypercholesterolemia), and sarcopenia (decreased skeletal muscle mass). This systemic inflammation can contribute to the progression of periodontitis by impairing immune responses and exacerbating the inflammatory processes in the periodontal tissues. Furthermore, individuals with NAFLD often exhibit altered lipid metabolism, which may affect oral microbiota composition, leading to dysbiosis and increased susceptibility to periodontal disease. Conversely, periodontitis has been linked to the progression of NAFLD through mechanisms involving systemic inflammation and oxidative stress. Chronic periodontal inflammation can release pro-inflammatory cytokines and bacterial toxins into the bloodstream, contributing to liver inflammation and exacerbating hepatic steatosis. Moreover, periodontitis-induced oxidative stress may promote hepatic lipid accumulation and IR, further aggravating NAFLD. The interplay between NAFLD and periodontitis underscores the importance of comprehensive management strategies targeting both conditions. Lifestyle modifications such as regular exercise, a healthy diet, and proper oral hygiene practices are crucial for preventing and managing these interconnected diseases. Additionally, interdisciplinary collaboration between hepatologists and periodontists is essential for optimizing patient care and improving outcomes in
C1 [Vegda, Hardika S.; Patel, Bhavin; Girdhar, Gaurav A.; Pathan, Mohd. Shabankhan H.; Kumar, Santosh] Karnavati Univ, Sch Dent, Dept Periodontol & Implantol, Gandhinagar, India.
   [Ahmad, Rahnuma] Med Coll Women & Hosp, Dept Physiol, Dhaka, Bangladesh.
   [Haque, Mainul] Karnavati Univ, Karnavati Sci Res Ctr KSRC, Dept Res, Sch Dent, Gandhinagar, India.
   [Haque, Mainul] Natl Def Univ Malaysia, Dept Pharmacol & Therapeut, Kuala Lumpur, Malaysia.
   [Sinha, Susmita] Enam Med Coll & Hosp, Dept Physiol, Dhaka, Bangladesh.
C3 Universiti Pertahanan Nasional Malaysia
RP Haque, M (corresponding author), Karnavati Univ, Karnavati Sci Res Ctr KSRC, Dept Res, Sch Dent, Gandhinagar, India.; Haque, M (corresponding author), Natl Def Univ Malaysia, Dept Pharmacol & Therapeut, Kuala Lumpur, Malaysia.
EM runurono@gmail.com
RI Pathan, Mohd Shafi/GXG-9674-2022; Haque, Mainul/ABG-2866-2020; Sinha,
   Susmita/HGC-1750-2022; Patel, Bhavin/KIC-1148-2024; Girdhar,
   DrGaurav/KIC-5802-2024; Kumar, Santosh/AHC-1924-2022; Ahmad,
   Rahnuma/ABB-3336-2021
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NR 202
TC 2
Z9 2
U1 7
U2 14
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
EI 2168-8184
J9 CUREUS J MED SCIENCE
JI Cureus J Med Sci
PD JUL 3
PY 2024
VL 16
IS 7
AR e63775
DI 10.7759/cureus.63775
PG 18
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA YC6G9
UT WOS:001266322200030
PM 39100036
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU de Brito, WA
   Ferreira, MRA
   Dantas, DDS
   Soares, LAL
AF de Brito, Wanessa Azevedo
   Assuncao Ferreira, Magda Rhayanny
   Dantas, Diego de Sousa
   Lira Soares, Luiz Alberto
TI Biological activities of Eugenia uniflora L. (pitangueira)
   extracts in oxidative stress-induced pathologies: A systematic review
   and meta-analysis of animal studies
SO PHARMANUTRITION
LA English
DT Review
DE Eugenia uniflora; Antioxidant Oxidative stress; Biological activity;
   Polyphenols
ID ANTIOXIDANT CAPACITY; SUPEROXIDE-DISMUTASE; METABOLIC SYNDROME; HEALTH;
   LEAVES; LIVER
AB Background: Eugenia uniflora L. (EU) is widely distributed geographically and has been used in traditional medicine owing to its range of therapeutic properties associated with antioxidant action. To determine the viability of this species as an herbal with promising pharmaceutical applications, we assessed the evidence from preclinical studies about the antioxidant potential of EU extracts as a natural source for prevention and treatment of diseases associated with oxidative stress.
   Methods: The search was conducted in the electronic databases: PubMed, ScienceDirect, and SciELO. In vivo studies related to the antioxidant properties and preclinical assays of this species were included. The risk of bias was assessed in all studies and meta-analysis was carried to summarize effect size of EU extracts.
   Results: From 738 reports, 7 studies were included in qualitative synthesis and 4 in meta-analysis. Studies using extracts or fractions, and different pharmacological activities were reported. Meta-analysis showed positive effects of EU versus control on superoxide dismutase levels in hippocampus (MD=6.59; 95% CI=4.56-8.63) and on cortex (MD=7.57; 95% CI=5.92-9.21); and glutathione peroxidase (GPx) on hippocampus (MD = 11.85; 95%CI = 10.42-13.29). However, EU extracts did not show significant effects on GPx levels on cortex (p = 0.56); on acetylcholinesterase on cortex (p = 0.05), and hippocampus (p = 0.66); and glutathione levels on liver (p = 0.38).
   Conclusion: In general, the studies have heterogeneity and some concerns about risk of bias, specially about randomization and blind outcome assessment. Current evidence of in vivo studies supports antioxidant action of EU extracts in brain tissue by increase of endogenous antioxidant molecules.
C1 [de Brito, Wanessa Azevedo; Assuncao Ferreira, Magda Rhayanny; Lira Soares, Luiz Alberto] Univ Fed Pernambuco, Dept Pharmaceut Sci, Lab Pharmacognosy, BR-50740521 Recife, PE, Brazil.
   [de Brito, Wanessa Azevedo; Lira Soares, Luiz Alberto] Univ Fed Pernambuco, Postgrad Program Pharmaceut Sci PPgCF, BR-50740600 Recife, PE, Brazil.
   [Dantas, Diego de Sousa] Univ Fed Pernambuco, Postgrad Program Physiotherapy PPgFT, BR-50740560 Recife, PE, Brazil.
C3 Universidade Federal de Pernambuco; Universidade Federal de Pernambuco;
   Universidade Federal de Pernambuco
RP Soares, LAL (corresponding author), Av Prof Arthur Sa, BR-50740521 Recife, PE, Brazil.
EM luiz.albertosoares@ufpe.br
RI Soares, Luiz/R-3373-2016; Assunção Ferreira, Magda/J-5374-2015; Dantas,
   Diego de Sousa/L-6373-2017
OI Dantas, Diego de Sousa/0000-0002-1966-3352; Lira Soares, Luiz
   Alberto/0000-0002-3142-6173
FU Fundacao de Amparo a Ciencia e Tecnologia do Estado de Pernambuco-FACEPE
   by Conselho Nacional de Desenvolvimento Cientifico e Tecnologico-CNPq
   [IBPG-1569-4.03/19, 380696/2020-7, 307110/2018-4]; CNPq [405297/2018-1]
FX The authors are grateful for the W.A.B. PhD scholarship provided by
   Fundacao de Amparo a Ciencia e Tecnologia do Estado de Pernambuco-FACEPE
   process number IBPG-1569-4.03/19, research grant for M.R.A. F. process
   number 380696/2020-7, and for L.A.L.S. process number 307110/2018-4
   provided by Conselho Nacional de Desenvolvimento Cientifico e
   Tecnologico-CNPq. This study was supported by the CNPq (405297/2018-1).
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NR 76
TC 3
Z9 3
U1 0
U2 4
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2213-4344
J9 PHARMANUTRITION
JI PharmaNutrition
PD JUN
PY 2022
VL 20
AR 100290
DI 10.1016/j.phanu.2022.100290
PG 11
WC Chemistry, Medicinal; Geriatrics & Gerontology; Gerontology; Nutrition &
   Dietetics; Pharmacology & Pharmacy
WE Emerging Sources Citation Index (ESCI)
SC Pharmacology & Pharmacy; Geriatrics & Gerontology; Nutrition & Dietetics
GA O0OA6
UT WOS:001040889000001
DA 2025-06-11
ER

PT J
AU Steed, MM
   Tyagi, SC
AF Steed, Mesia M.
   Tyagi, Suresh C.
TI Mechanisms of Cardiovascular Remodeling in Hyperhomocysteinemia
SO ANTIOXIDANTS & REDOX SIGNALING
LA English
DT Review
ID NITRIC-OXIDE; PLASMA HOMOCYSTEINE; OXIDATIVE STRESS;
   METHYLENETETRAHYDROFOLATE REDUCTASE; ENDOTHELIAL DYSFUNCTION; METABOLIC
   SYNDROME; HEART-DISEASE; GLOBAL BURDEN; RISK-FACTORS; METHIONINE
AB In hypertension, an increase in arterial wall thickness and loss of elasticity over time result in an increase in pulse wave velocity, a direct measure of arterial stiffness. This change is reflected in gradual fragmentation and loss of elastin fibers and accumulation of stiffer collagen fibers in the media that occurs independently of atherosclerosis. Similar results are seen with an elevated level of homocysteine (Hcy), known as hyperhomocysteinemia (HHcy), which increases vascular thickness, elastin fragmentation, and arterial blood pressure. Studies from our laboratory have demonstrated a decrease in elasticity and an increase in pulse wave velocity in HHcy cystathionine beta synthase heterozygote knockout (CBS-/+) mice. Nitric oxide (NO) is a potential regulator of matrix metalloproteinase (MMP) activity in MMP-NO-TIMP (tissue inhibitor of metalloproteinase) inhibitory tertiary complex. We have demonstrated the contribustion of the NO synthase (NOS) isoforms, endothelial NOS and inducible NOS, in the activation of latent MMP. The differential production of NO contributes to oxidative stress and increased oxidative/nitrative activation of MMP resulting in vascular remodeling in response to HHcy. The contribution of the NOS isoforms, endothelial and inducible in the collagen/elastin switch, has been demonstrated. We have showed that an increase in inducible NOS activity is a key contributor to HHcy-mediated collagen/elastin switch and resulting decline in aortic compliance. In addition, increased levels of Hcy compete and suppress the gamma-amino butyric acid-receptor, N-methyl-D-aspartame-receptor, and peroxisome proliferator-activated receptor. The HHcy causes oxidative stress by generating nitrotyrosine, activating the latent MMPs and decreasing the endothelial NO concentration. The HHcy causes elastinolysis and decrease elastic complicance of the vessel wall. The treatment with gamma-amino butyric acid-receptor agonist (muscimol), N-methyl-D-aspartame-receptor agonist (MK-801), and peroxisome proliferator-activated receptor agonists (ciprofibrate and ciglitazone) mitigates the cardiovascular dysfunction in HHcy. Antioxid. Redox Signal. 15, 1927-1943.
C1 [Steed, Mesia M.; Tyagi, Suresh C.] Univ Louisville, Sch Med, Dept Physiol & Biophys, Louisville, KY 40202 USA.
C3 University of Louisville
RP Tyagi, SC (corresponding author), Univ Louisville, Sch Med, Dept Physiol & Biophys, 500 S Preston St, Louisville, KY 40202 USA.
EM s0tyag01@louisville.edu
FU NIH [HL-71010, HL-74185, HL-88012, NS-51568]
FX A part of this study was supported by NIH grants HL-71010, HL-74185,
   HL-88012, and NS-51568.
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NR 84
TC 144
Z9 173
U1 1
U2 20
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1523-0864
EI 1557-7716
J9 ANTIOXID REDOX SIGN
JI Antioxid. Redox Signal.
PD OCT
PY 2011
VL 15
IS 7
BP 1927
EP 1943
DI 10.1089/ars.2010.3721
PG 17
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 818QY
UT WOS:000294770900013
PM 21126196
OA Green Published
DA 2025-06-11
ER

PT J
AU Bouanane, S
   Benkalfat, NB
   Ahmed, FZB
   Merzouk, H
   Mokhtari, NS
   Merzouk, SA
   Gresti, J
   Tessier, C
   Narce, M
AF Bouanane, Samira
   Benkalfat, Nassira B.
   Ahmed, Fatima-Zohra Baba
   Merzouk, Hafida
   Mokhtari, Nassima S.
   Merzouk, Sid-Ahmed
   Gresti, Joseph
   Tessier, Christian
   Narce, Michel
TI Time course of changes in serum oxidant/antioxidant status in overfed
   obese rats and their offspring
SO CLINICAL SCIENCE
LA English
DT Article
DE insulin; leptin; lipid; maternal obesity; offspring; oxidant/antioxidant
   status
ID ANTIOXIDANT CAPACITY; MATERNAL NUTRITION; OXIDATIVE STRESS; RICH DIET;
   MODELS; ACID; PREGNANCY; LEPTIN
AB The aim of the present study was to determine the time course of changes in oxidant/antioxidant status, as well as serum glucose, insulin, leptin and lipid levels, liver adipose tissue and muscle lipid and protein contents, in cafeteria-diet-fed dams during gestation and lactation, and in their offspring throughout adulthood. Food intake was also evaluated. The cafeteria diet induced a significant increase in maternal body and relative adipose tissue weights, daily energy intake, and plasma glucose, insulin, leptin and lipid levels at parturition (day 0) and at the end of lactation (day 21). Plasma total antioxidant status [ORAC (oxygen radical absorbance capacity)], erythrocyte catalase and SOD (superoxide dismutase) activities were lower, whereas plasma hydroperoxide and carbonyl protein levels were higher in cafeteria-diet-fed mothers compared with control mothers at days 0 and 21. Pups from cafeteria-diet-fed dams, both males and females, also had consistently higher body and relative adipose tissue weights, and plasma glucose, insulin, leptin, triacylglycerol (triglyceride) and cholesterol levels at birth (day 0), weaning (day 21) and 3 months of age (day 90). These offspring had significantly lower ORAC and catalase activity, and higher plasma hydroperoxide and carbonyl protein levels and SOD activity at birth, at days 21 and 90 compared with control offspring. In conclusion, excessive maternal fat and energy intake can play an important role in the development of metabolic disorders in the offspring. Maternal oxidative stress may be among the responsible factors. Fetal oxidative stress may present an additional confounding influence and probably contributes to additional disorders, aggravating features of the metabolic syndrome. An improvement in maternal oxidant/antioxidant status during pregnancy and lactation, with adequate nutrition, could have beneficial effects on the progeny.
C1 [Bouanane, Samira; Benkalfat, Nassira B.; Ahmed, Fatima-Zohra Baba; Merzouk, Hafida; Mokhtari, Nassima S.] Univ Abou Bekr Belkaid Tlemcen, Dept Mol & Cellular Biol, Lab Physiol & Biochem Nutr, Tilimsen 13000, Algeria.
   [Merzouk, Sid-Ahmed] Univ Abou Bekr Belkaid Tlemcen, Dept Phys, Fac Sci, Tilimsen 13000, Algeria.
   [Gresti, Joseph; Tessier, Christian; Narce, Michel] Univ Bourgogne, Fac Sci, INSERM, UMR 866, F-21000 Dijon, France.
C3 Universite Abou Bekr Belkaid; Universite Abou Bekr Belkaid; Institut
   National de la Sante et de la Recherche Medicale (Inserm); Institut
   Agro; AgroSup Dijon; Universite Bourgogne Europe
RP Merzouk, H (corresponding author), Univ Abou Bekr Belkaid Tlemcen, Dept Mol & Cellular Biol, Lab Physiol & Biochem Nutr, Tilimsen 13000, Algeria.
EM hafidamerzouk_2@hotmail.com
RI mokhtari, nassima/F-7775-2013
OI nassima, mokhtari soulimane/0000-0002-6934-5168; merzouk,
   hafida/0000-0001-5081-3358; Narce, Michel/0000-0002-9986-6247
FU French Foreign Office [TASSILI 08MDU 723]; Algerian Research
   Investigation Office (CNEPRU) [I02020070010]
FX This work was supported by the French Foreign Office [International
   Research Extension Grant TASSILI 08MDU 723]; and by the Algerian
   Research Investigation Office (CNEPRU) [grant number I02020070010].
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NR 49
TC 40
Z9 47
U1 0
U2 3
PU PORTLAND PRESS LTD
PI LONDON
PA 1ST FLR, 10 QUEEN STREET PLACE, LONDON, ENGLAND
SN 0143-5221
EI 1470-8736
J9 CLIN SCI
JI Clin. Sci.
PD APR
PY 2009
VL 116
IS 7-8
BP 669
EP 680
DI 10.1042/CS20080413
PG 12
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 429HM
UT WOS:000264911500012
PM 18986302
DA 2025-06-11
ER

PT J
AU Vitale, E
   Galatola, V
   Mea, R
   Di Dio, F
   Canonico, A
AF Vitale, Elsa
   Galatola, Vito
   Mea, Rocco
   Di Dio, Francesca
   Canonico, Anna
TI The Linkage "Body Mass Index-Insomnia Levels-Eating Disorder
   Flexibility" in Italian Nurses During the Covid-19 Outbreak: A
   Psychoendocrinological Employment Disease
SO ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS
LA English
DT Article
DE Body mass index; Covid-19; eating disorder; insomnia disorder; nurse;
   psychoendocrinological disease
ID HEALTH-CARE WORKERS; SLEEP DURATION; METABOLIC SYNDROME;
   GENDER-DIFFERENCES; SHIFT WORK; JOB STRESS; SYMPTOMS; PREVALENCE;
   ASSOCIATION; EXPERIENCES
AB Aim: To evaluate differences between insomnia condition and the flexibility attitude to eat in Italian nurses directly involved in the care of patients affected by Covid-19 according to sex, Body Mass Index, shift working condition and incidence of new Covid-19 cases in the region of participants. Moreover, any correlations between the insomnia condition and the flexibile attitude to eat have been investigated.
   Methods: An online questionnaire was administered in October 2020, which included: the socio-demographic section, the insomnia condition assessment and the behavioral flexibility evaluation to develop in connection with developing an eating disorder.
   Results: 341 Italian nurses answered the questionnaire. Regarding the insomnia condition levels, nurses belonging to regions with a higher incidence rate of the Covid-19 pandemic recorded higher levels of insomnia than others (p=.004). Females and nurses belonging to regions with lower Covid-19 incidence rate recorded a significant higher total eating flexibility attitude (p=.003; p<.001), also, in the Food and Exercise flexibility (p=.007; p<.001). As regards the flexibility attitude for weight and shape, significant differences were recorded among nurses according to their BMI values (p<.001) and to their incidence rate of the belonging region (p<.001). The insomnia condition levels significantly correlated with the flexibility attitude to eat both in its total score (p=.010), in the general score (p=.010) and in the weight and shape score (p<.001). All correlations between the insomnia conditions and the flexibility to eat were significantly inverse with the exception for of the food and exercise dimension. All the flexibility attitudes to eat sub dimensions significantly correlated among them (p<.001).
   Conclusion: There was a direct correlation among socio-demographic factors, BMI values, insomnia and behavioral flexibility scores in Italian nurses so, it could be assumed that the nursing profession is at risk of developing a metabolic syndrome condition and, therefore, it could be considered as a psychoendocrinological employment disease during the Covid-19 outbreak.
C1 [Vitale, Elsa] Local Hlth Co, Ctr Mental Hlth Modugno, Bari, Italy.
   [Galatola, Vito] Local Hlth Co, Occidental Hosp Castellaneta, Taranto, Italy.
   [Mea, Rocco] San Carlo Hosp, Potenza, Italy.
   [Di Dio, Francesca] Planet Hlth Multi Specialist Ctr, Bari, Italy.
   [Canonico, Anna] Di Venere Hosp, Local Hlth Co, Cardiol Unit, Bari, Italy.
RP Vitale, E (corresponding author), Local Hlth Co, Ctr Mental Hlth Modugno, ASL, Via X Marzo 43, Bari, Italy.
EM vitaleelsa@libero.it
RI MEA, ROCCO/GOJ-7458-2022; Vitale, Elsa/D-8904-2018
OI Vitale, Elsa/0000-0002-9738-3479
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NR 98
TC 5
Z9 5
U1 0
U2 3
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1871-5303
EI 2212-3873
J9 ENDOCR METAB IMMUNE
JI Endocr. Metab. Immune Disord.-Drug Targets
PY 2022
VL 22
IS 5
BP 490
EP 501
DI 10.2174/1871530321666210715125939
PG 12
WC Endocrinology & Metabolism; Immunology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Immunology; Pharmacology & Pharmacy
GA 6L0PS
UT WOS:000887892500004
PM 34269670
DA 2025-06-11
ER

PT J
AU Vanella, L
   Russo, GI
   Cimino, S
   Fragalà, E
   Favilla, V
   Volti, GL
   Barbagallo, I
   Sorrenti, V
   Morgia, G
AF Vanella, Luca
   Russo, Giorgio Ivan
   Cimino, Sebastiano
   Fragala, Eugenia
   Favilla, Vincenzo
   Volti, Giovanni Li
   Barbagallo, Ignazio
   Sorrenti, Valeria
   Morgia, Giuseppe
TI Correlation Between Lipid Profile and Heme Oxygenase System in Patients
   With Benign Prostatic Hyperplasia
SO UROLOGY
LA English
DT Article
ID URINARY-TRACT SYMPTOMS; METABOLIC SYNDROME; OXIDATIVE STRESS;
   INFLAMMATION; EXPRESSION; INSULIN; RISK; HO-1; AMPK; ASSOCIATION
AB OBJECTIVE To investigate the role of heme oxygenase (HO) system in moderate to severe benign prostatic hyperplasia and lower urinary tract symptom patients and the influence of metabolic syndrome (MetS) components on HO-1 or HO-2 prostatic levels.
   METHODS One hundred thirty-two consecutive patients who underwent transurethral resection of the prostate were prospectively enrolled. MetS was defined by the International Diabetes Federation. Patients were divided in 2 groups: group A (high-density lipoprotein-cholesterol [HDL-C] >= 40 mg/dL and triglycerides <150 mg/dL) and group B (HDL-C <40 mg/dL and triglycerides >= 150 mg/dL). Surgical specimens were collected for HO level determination. HO-1 levels were determined by enzyme-linked immunosorbent assay and HO-1 levels by Western blotting.
   RESULTS Patients with MetS showed lower levels of HO-1 (5.29 vs 6.28 ng/mL; P = .04), HO-2 (1.01 vs 1.83 ng/mL; P = .04), phosphorylated activated protein kinase (pAMPK; 0.62 vs 1.11 AUI; P <.01), and HO-activity (61.43 vs 70.22 AUI; P <.01) with respect to normal. The Pearson correlation analysis showed that HO-1, HO-2, and HO activity were negatively associated with waist circumference (P <.05), body mass index (P <.05), triglycerides (P <.05) and positively with HDL-C (P <.05). Group B showed lower levels of HO-1 (4.7 vs 6.6 ng/mL; P <.05), HO-2 (1.4 vs 0.4 ng/mL; P - .03), HO-activity (69.63 vs 58.42 AUI; P - .04), and higher International Prostate Symptoms Score (21.4 vs 25.0; P <.05) with respect to group A. The enzyme-linked immunosorbent assay showed that HO-1 and HO activity levels were significantly lower in group B compared with group A. Reduced HDL-C and elevated triglyceride levels decreased HO-1 expression in the prostate tissue. Western blot analysis of tissue samples showed significant differences in basal protein expression levels of HO-2 and pAMPK in group B compared with group A.
   CONCLUSION Alteration of serum triglycerides and HDL-C significantly impairs HO-1 and HO-2 levels in benign prostatic hyperplasia patients. (C) 2014 Elsevier Inc.
C1 Univ Catania, Dept Drug Sci, Biochem Sect, I-95100 Catania, Italy.
   Univ Catania, Policlin Hosp, Dept Urol, I-95100 Catania, Italy.
C3 University of Catania; University of Catania; University Catania
   Hospital
RP Russo, GI (corresponding author), Univ Catania, Policlin Hosp, Sch Med, Dept Urol, I-95100 Catania, Italy.
EM giorgioivan@virgilio.it
RI Volti, Giovanni/A-2435-2008; Gentile, Giuseppe/A-2745-2012; Favilla,
   Vincenzo/AAB-5801-2022; Russo, Giorgio/I-3347-2019; Vanella,
   Luca/J-7354-2016
OI Morgia, Giuseppe/0000-0002-7224-7577; Russo, Giorgio
   Ivan/0000-0003-4687-7353; Barbagallo, Ignazio/0000-0002-7761-0662;
   Vanella, Luca/0000-0002-6314-6029; Sorrenti,
   Valeria/0000-0002-5973-1495; Li Volti, Giovanni/0000-0002-8678-2183
CR Abraham NG, 2008, CURR PHARM DESIGN, V14, P412, DOI 10.2174/138161208783597371
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NR 32
TC 35
Z9 36
U1 1
U2 5
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0090-4295
EI 1527-9995
J9 UROLOGY
JI Urology
PD JUN
PY 2014
VL 83
IS 6
AR 1444.e7
DI 10.1016/j.urology.2014.03.007
PG 7
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA AI0DL
UT WOS:000336516300054
PM 24862399
DA 2025-06-11
ER

PT J
AU Roskaric, P
   Speranda, M
   Masek, T
   Verbanac, D
   Starcevic, K
AF Roskaric, Petra
   Speranda, Marcela
   Masek, Tomislav
   Verbanac, Donatella
   Starcevic, Kristina
TI Low Dietary n6/n3 Ratio Attenuates Changes in the NRF 2 Gene Expression,
   Lipid Peroxidation, and Inflammatory Markers Induced by Fructose
   Overconsumption in the Rat Abdominal Adipose Tissue
SO ANTIOXIDANTS
LA English
DT Article
DE adipose tissue; metabolic syndrome; oxidative stress; DHA; fatty acids
ID POLYUNSATURATED FATTY-ACIDS; STEAROYL-COA DESATURASE; INSULIN
   SENSITIVITY; DRINKING-WATER; GLUCOSE; ADIPONECTIN; SUCROSE; OBESITY;
   BETA; HYPERTENSION
AB The objective of this study was to examine the benefits of different n6/n3 polyunsaturated fatty acid ratios on the lipid metabolism, insulin resistance, and oxidative stress in the adipose tissue of rats fed a high-fructose diet. Male and female rats were divided into four groups: a control group (CON) (n6/n3 ratio ~7), a high-fructose group (HF) (n6/n3 ratio ~7), an N6-HF group (n6/n3 ratio ~50), and the DHA-HF group (n6/n3 ratio ~1, with the addition of docosahexaenoic (DHA) and eicosapentaenoic (EPA) acid). The CON group received plain water and the HF group received 15% fructose in their drinking water. Fructose induced an increase in the content of serum triglycerides, serum cholesterol, and HOMA-IR index. Among the fatty acids, elevated proportions of C18:1n9 and C16:1n7, as well as an increase in total monounsaturated fatty acid (MUFA), were found in the adipose tissue of the HF group. Fructose treatment also changed oxidative parameters, including a marked increase in the serum malondialdehyde (MDA) content. Meanwhile, DHA supplementation caused a significant decrease in the serum MDA concentration in comparison with the HF group. In addition, DHA/EPA supplementation attenuated oxidative stress by increasing NRF 2 gene expression. Fructose treatment also significantly decreased the adiponectin level, while DHA supplementation ameliorated it. The changes observed in this trial, including the decrease in the content of DHA and EPA, the decreased EPA/ARA ratio, and the increase in the expression of inflammatory genes, are characteristics of the low-grade inflammation caused by fructose treatment. These changes in the rat adipose tissue could be prevented by dietary intervention consisting of DHA supplementation and a low n6/n3 ratio.
C1 [Roskaric, Petra; Starcevic, Kristina] Univ Zagreb, Fac Vet Med, Dept Chem & Biochem, Heinzelova 55, Zagreb 10000, Croatia.
   [Speranda, Marcela] Univ Osijek, Fac Agr, Dept Anim Sci, Vladimira Preloga 1, Osijek 31000, Croatia.
   [Masek, Tomislav] Univ Zagreb, Fac Vet Med, Dept Anim Nutr & Dietet, Heinzelova 55, Zagreb 10000, Croatia.
   [Verbanac, Donatella] Univ Zagreb, Fac Pharm & Biochem, Dept Med Biochem & Hematol, A Kovacica 1, Zagreb 10000, Croatia.
C3 University of Zagreb; University of JJ Strossmayer Osijek; University of
   Zagreb; University of Zagreb
RP Starcevic, K (corresponding author), Univ Zagreb, Fac Vet Med, Dept Chem & Biochem, Heinzelova 55, Zagreb 10000, Croatia.
EM petra.roskaric@vef.hr; marcela.speranda@fazos.hr; tomislav.masek@vef.hr;
   donatella.verbanac@pharma.unizg.hr; kristina.starcevic@vef.hr
RI Speranda, Marcela/GWZ-8300-2022; Verbanac, Donatella/AAN-1947-2021
OI Speranda, Marcela/0000-0003-0785-5485; Masek,
   Tomislav/0000-0002-6103-4728; Verbanac, Donatella/0000-0002-9106-1604;
   Starcevic, Kristina/0000-0002-2606-7807
FU Croatian Science Foundation [IP-2016-06-3163]
FX This study was supported by the Croatian Science Foundation as the part
   of a project ]]Dietary lipids, sex and age in pathogenesis of metabolic
   syndrome (IP-2016-06-3163) granted to Kristina Starcevic
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NR 61
TC 9
Z9 10
U1 0
U2 10
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD DEC
PY 2021
VL 10
IS 12
AR 2005
DI 10.3390/antiox10122005
PG 14
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA XW7FX
UT WOS:000735781300001
PM 34943108
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Yasu, T
   Kobayashi, M
   Mutoh, A
   Yamakawa, K
   Momomura, S
   Ueda, S
AF Yasu, Takanori
   Kobayashi, Mayumi
   Mutoh, Akiko
   Yamakawa, Ken
   Momomura, Shin-ichi
   Ueda, Shinichiro
TI Dihydropyridine calcium channel blockers inhibit
   non-esterified-fatty-acid-induced endothelial and rheological
   dysfunction
SO CLINICAL SCIENCE
LA English
DT Article
DE calcium channel blocker; endothelial function; leucocyte; non-esterified
   fatty acid (NEFA); oxidative stress
ID NITRIC-OXIDE BIOAVAILABILITY; RANDOMIZED CONTROLLED-TRIAL;
   CORONARY-ARTERY-DISEASE; SMOOTH-MUSCLE-CELLS; NF-KAPPA-B;
   HUMAN-NEUTROPHILS; PROTEIN-KINASE; CARDIOVASCULAR-DISEASE;
   ESSENTIAL-HYPERTENSION; LEUKOCYTE ACTIVATION
AB Circulating NEFAs (non-esterified fatty acids) from adipose tissue lipolysis lead to endothelial dysfunction and insulin resistance in patients with the metabolic syndrome or Type 2 diabetes mellitus. The aim of the present study was to test the hypothesis that DHP (dihydropyridine) CCBs (calcium channel blockers) prevent NEFA-induced endothelial and haemorheological dysfunction independently of their antihypertensive properties. Using a double-blind cross-over study design, nifedipine, amlodipine, diltiazem or placebo were administered to eight healthy subjects for 2 days before each study day. On the study days, the following were assessed before and after the infusion of lipid and heparin to raise serum NEFAs: endothelial function, by measuring FBF (forearm blood flow) responses to ACh (acetylcholine); leucocyte activation, by ex vivo measurement of plasma MPO (myeloperoxidase) levels, adherent leucocyte numbers and whole blood transit time through microchannels; and oxidative stress, by determining plasma levels of d-ROMs (derivatives of reactive oxygen metabolites). Effects of the CCBs on NF-kappa B (nuclear factor kappa B) p65 phospholylation stimulated by NEFAs were assessed in cultured monocytic cells in vitro. Elevated NEFAs reduced the responses to ACh and significantly increased whole blood transit time, adherent leucocyte numbers and d-ROMs. Nifedipine and amlodipine, but not diltiazem, prevented NEFA-induced endothelial dysfunction, leucocyte activation and enhancement of oxidative stress without affecting BP (blood pressure), whereas all these drugs prevented NEFA-induced p65 activation in vitro. These results suggest that DHP CCBs, independent of their antihypertensive properties in humans, prevent NEFA-induced endothelial and haemorheological dysfunction through inhibition of NEFA-induced leucocyte activation, although the sensitivity to drugs of leucocyte Ca2+ channels may differ among cells.
C1 [Yasu, Takanori; Kobayashi, Mayumi; Mutoh, Akiko; Yamakawa, Ken; Ueda, Shinichiro] Univ Ryukyus, Sch Med, Dept Clin Pharmacol & Therapeut, Okinawa, Japan.
   [Momomura, Shin-ichi] Jichi Med Univ, Saitama Med Ctr, Dept Integrated Med 1, Saitama, Japan.
C3 University of the Ryukyus; Jichi Medical University
RP Ueda, S (corresponding author), Univ Ryukyus, Sch Med, Dept Clin Pharmacol & Therapeut, Okinawa, Japan.
EM blessyou@med.u-ryukyu.ac.jp
RI Yasu, Takanori/AAF-1668-2019
OI Mutoh, Akiko/0000-0001-5282-8182
FU Ministry of Education, Science and Culture of Japan [16590439,
   20590542]; Vehicle Racing Commemorative Foundation; Grants-in-Aid for
   Scientific Research [16590439, 22590503, 20590542] Funding Source: KAKEN
FX This work was supported by Grants-in-Aid from the Ministry of Education,
   Science and Culture of Japan [grant numbers16590439 (to S.U.) and
   20590542 (to K.Y.)] and from the Vehicle Racing Commemorative Foundation
   (to S.M. and T.Y.).
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NR 49
TC 21
Z9 22
U1 0
U2 13
PU PORTLAND PRESS LTD
PI LONDON
PA CHARLES DARWIN HOUSE, 12 ROGER STREET, LONDON WC1N 2JU, ENGLAND
SN 0143-5221
EI 1470-8736
J9 CLIN SCI
JI Clin. Sci.
PD SEP
PY 2013
VL 125
IS 5-6
BP 247
EP 255
DI 10.1042/CS20120311
PG 9
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 192SA
UT WOS:000322504400003
PM 23535137
DA 2025-06-11
ER

PT J
AU Taleb, A
   Witztum, JL
   Tsimikas, S
AF Taleb, Adam
   Witztum, Joseph L.
   Tsimikas, Sotirios
TI Oxidized phospholipids on apoB-100-containing lipoproteins: a biomarker
   predicting cardiovascular disease and cardiovascular events
SO BIOMARKERS IN MEDICINE
LA English
DT Review
DE atherosclerosis; biomarker; lipoproteins; outcome; oxidation; oxidative
   stress; oxidized phospholipid
ID LOW-DENSITY-LIPOPROTEIN; ACUTE CORONARY SYNDROMES; APOLIPOPROTEIN B-100
   PARTICLES; OXIDATION-SPECIFIC EPITOPES; ENDOPLASMIC-RETICULUM STRESS;
   LP(A) LIPOPROTEIN; ARTERY-DISEASE; HEART-DISEASE; PLASMA-LEVELS;
   FAMILIAL HYPERCHOLESTEROLEMIA
AB Oxidative stress is a well-known etiologic factor in the development of cardiovascular disease. Oxidation of lipoproteins, and in particular of low density lipoprotein, is a necessary if not obligatory mechanism for the generation of macrophage-derived foam cells, the first major initiating factor in the development of an atherosclerotic plaque. Oxidation of lipoproteins does not result in the generation of a single, defined molecular species, but of a variety of oxidation-specific epitopes, such as oxidized phospholipids and malondialdehyde-lysine epitopes. Unique monoclonal antibodies have been developed to bind these well-defined epitopes, and have been used in in vitro assays to detect them on circulating lipoproteins present in plasma. This article will summarize the accumulating clinical data of one oxidation-specific biomarker, oxidized phospholipids (OxPL) on apoB-100 lipoproteins. Elevated levels of OxPL/apoB predict the presence and progression of coronary, femoral and carotid artery disease, are increased following acute coronary syndromes and percutaneous coronary intervention, and predict the development of death, myocardial infarction, stroke and need for revascularization in unselected populations. OxPL/apoB levels are independent of traditional risk factors and the metabolic syndrome, and enhance the risk prediction of the Framingham Risk Score. The OxPLs measured in this assay reflect the biological activity of the most atherogenic lipoprotein(a) (Lp(a)) particles, reflected in patients with high plasma Lp(a) levels with small apo(a) isoforms. The predictive value of OxPL/apoB is amplified by Lp(a) and phospholipases such as lipoprotein-associated phospholipase A(2) and secretory phospholipase A(2), which are targets of therapy in clinical trials. This assay has now been validated in over 10,000 patients and efforts are underway to make it available to the research and clinical communities.
C1 [Tsimikas, Sotirios] Univ Calif San Diego, Vasc Med Program, Div Cardiol, Dept Med, La Jolla, CA 92093 USA.
   [Witztum, Joseph L.] Univ Calif San Diego, Div Endocrinol, Dept Med, La Jolla, CA 92093 USA.
C3 University of California System; University of California San Diego;
   University of California System; University of California San Diego
RP Tsimikas, S (corresponding author), Univ Calif San Diego, Vasc Med Program, Div Cardiol, Dept Med, 9500 Gilman Dr,BSB 1080, La Jolla, CA 92093 USA.
EM stsimikas@ucsd.edu
FU Fondation Leducq; Merck; Pfizer, Inc.
FX This study was supported by the Fondation Leducq. JL Witztum and S
   Tsimikas are named as co-inventors of patents and patent applications
   owned by the University of California for the clinical use of
   oxidation-specific antibodies. JL Witztum is a consultant to ISIS, Inc,
   Regulus and Lpath. S Tsimikas is a consultant to Quest, ISIS, Genzyme
   and Sanofi, Inc. and has received investigator-initiated grant research
   funding from Merck and Pfizer, Inc. JL Witztum and S Tsimikas are
   directors and have equity in Atherotope, Inc. The authors have no other
   relevant affiliations or financial involvement with any organization or
   entity with a financial interest in or financial conflict with the
   subject matter or materials discussed in the manuscript apart from those
   disclosed.
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NR 75
TC 148
Z9 153
U1 0
U2 27
PU FUTURE MEDICINE LTD
PI LONDON
PA UNITEC HOUSE, 3RD FLOOR, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON, N3
   1QB, ENGLAND
SN 1752-0363
J9 BIOMARK MED
JI Biomark. Med.
PD OCT
PY 2011
VL 5
IS 5
BP 673
EP 694
DI 10.2217/BMM.11.60
PG 22
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 857TW
UT WOS:000297744900024
PM 22003918
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Burghardt, PR
   Flagel, SB
   Burghardt, KJ
   Britton, SL
   Gerard-Koch, L
   Watson, SJ
   Akil, H
AF Burghardt, Paul R.
   Flagel, Shelly B.
   Burghardt, Kyle J.
   Britton, Steven L.
   Gerard-Koch, Lauren
   Watson, Stanley J.
   Akil, Huda
TI Risk-assessment and Coping Strategies Segregate with Divergent Intrinsic
   Aerobic Capacity in Rats
SO NEUROPSYCHOPHARMACOLOGY
LA English
DT Article
DE risk assessment; coping; stress; CRH; corticosterone; desipramine
ID CORTICOTROPIN-RELEASING HORMONE; PITUITARY-ADRENAL AXIS; ARTIFICIAL
   SELECTION; DEPRESSIVE SYMPTOMS; MESSENGER-RNA; DEFENSIVE BEHAVIORS;
   VOLUNTARY EXERCISE; METABOLIC SYNDROME; CAT ODOR; STRESS
AB Metabolic function is integrally related to an individual's susceptibility to, and progression of, disease. Selective breeding for intrinsic treadmill running in rats has produced distinct lines of high-or low-capacity runners (HCR and LCR, respectively) that exhibit numerous physiological differences. To date, the role of intrinsic aerobic capacity on behavior and stress response in these rats has not been addressed and was the focus of these studies. HCR and LCR rats did not differ in their locomotor response to novelty or behavior in the light/dark box. In contrast, immobility in the forced swim test was higher in LCR rats compared with HCR rats, regardless of desipramine treatment. Although both HCR and LCR rats responded to cat odor with decreased exploration and increased risk assessment, HCR rats showed greater contextual conditioning to cat odor. HCR rats exhibited higher expression of corticotropin-releasing hormone in the central nucleus of the amygdala, as well as heavier adrenal and thymus weight. Corticosterone was comparable among HCR and LCR rats at light/dark transitions, and in response to unavoidable cat odor. HCR rats, however, exhibited a greater corticosterone response following the light/dark box. These experiments show that the LCR phenotype associates with decreased risk assessment in response to salient danger signals and passive coping. In contrast, HCR rats show a more naturalistic strategy in that they employ active coping and a more vigilant and cautious response to environmental novelty and salient danger signals. Within this context, we propose that intrinsic aerobic capacity is a central feature mechanistically linking complex metabolic disease and behavior. Neuropsychopharmacology (2011) 36, 390-401; doi:10.1038/npp.2010.144; published online 6 October 2010
C1 [Burghardt, Paul R.; Flagel, Shelly B.; Watson, Stanley J.; Akil, Huda] Univ Michigan, Mol & Behav Neurosci Inst, Ann Arbor, MI 48109 USA.
   [Burghardt, Kyle J.] Univ Michigan, Coll Pharm, Ann Arbor, MI 48109 USA.
   [Britton, Steven L.; Gerard-Koch, Lauren] Univ Michigan, Dept Anesthesiol, Ann Arbor, MI 48109 USA.
C3 University of Michigan System; University of Michigan; University of
   Michigan System; University of Michigan; University of Michigan System;
   University of Michigan
RP Burghardt, PR (corresponding author), Univ Michigan, Mol & Behav Neurosci Inst, 209 Zina Pitcher Pl, Ann Arbor, MI 48109 USA.
EM pburghar@umich.edu
RI Flagel, Shelly/G-5561-2012; Burghardt, Kyle/G-1319-2018
OI Burghardt, Kyle/0000-0003-2319-5149
FU NIH [P01 DA021633, 5T32HD007422-18, UL1RR024986]; Office of Naval
   Research [N00014-09-1-0598]; National Center for Research Resources,
   National Institutes of Health [R24RR017718]
FX This work was supported by NIH Grants No. P01 DA021633 to HA, No.
   5T32HD007422-18, and No. UL1RR024986, and the Office of Naval Research
   Grant No. N00014-09-1-0598 to HA. The LCR and HCR rat resource was
   supported by Award R24RR017718 to SLB and LGK from the National Center
   for Research Resources (a component of the National Institutes of
   Health). We acknowledge the expert care of the rat colony provided by
   Molly Kalahar and Lori Gilligan.
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NR 60
TC 16
Z9 24
U1 0
U2 3
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0893-133X
EI 1740-634X
J9 NEUROPSYCHOPHARMACOL
JI Neuropsychopharmacology
PD JAN
PY 2011
VL 36
IS 2
BP 390
EP 401
DI 10.1038/npp.2010.144
PG 12
WC Neurosciences; Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA 694JE
UT WOS:000285292200002
PM 20927049
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Charlton, M
   Krishnan, A
   Viker, K
   Sanderson, S
   Cazanave, S
   McConico, A
   Masuoko, H
   Gores, G
AF Charlton, Michael
   Krishnan, Anuradha
   Viker, Kimberly
   Sanderson, Schuyler
   Cazanave, Sophie
   McConico, Andrea
   Masuoko, Howard
   Gores, Gregory
TI Fast food diet mouse: novel small animal model of NASH with ballooning,
   progressive fibrosis, and high physiological fidelity to the human
   condition
SO AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
LA English
DT Article
DE nonalcoholic steatohepatitis; hepatocellular ballooning; nonalcoholic
   fatty liver disease
ID FATTY LIVER-DISEASE; NONALCOHOLIC STEATOHEPATITIS; INSULIN-RESISTANCE;
   HEPATIC STEATOSIS; EXTRACELLULAR-MATRIX; FRUCTOSE CONSUMPTION; METABOLIC
   SYNDROME; NUTRITIONAL MODEL; GENE-EXPRESSION; GROWTH-HORMONE
AB Charlton M, Krishnan A, Viker K, Sanderson S, Cazanave S, McConico A, Masuoko H, Gores G. Fast food diet mouse: novel small animal model of NASH with ballooning, progressive fibrosis, and high physiological fidelity to the human condition. Am J Physiol Gastrointest Liver Physiol 301: G825-G834, 2011. First published August 11, 2011; doi: 10.1152/ajpgi.00145.2011.-Although there are small animal platforms that recapitulate some of the histological features of nonalcoholic fatty liver disease, there are no small animal models of nonalcoholic steatohepatitis (NASH) with consistent hepatocellular ballooning and progressive fibrosis that also exhibit fidelity to the human condition physiologically. We examined the metabolic and histological effects of a diet on the basis of the composition of "fast food" (high saturated fats, cholesterol, and fructose). Mice (n = 8 in each group) were assigned to diets as follows: 1) standard chow (SC), i.e., 13% energy as fat [1% saturated fatty acids (SFA)], 2) high fat (HF), i.e., 60% energy as fat (1% SFA), and 3) fast food (FF), i.e., 40% energy as fat (12% SFA, 2% cholesterol). All three diets were supplemented with high fructose. All diets produced obesity. The HF and FF diets produced insulin resistance. Liver histology was normal in animals fed the SC diet. Steatohepatitis with pronounced ballooning and progressive fibrosis (stage 2) was observed in mice fed the FF diet. Although the HF diet produced obesity, insulin resistance, and some steatosis; inflammation was minimal, and there was no increase in fibrosis. The FF diet produced a gene expression signature of increased fibrosis, inflammation, and endoplasmic reticulum stress and lipoapoptosis. A diet based on high cholesterol, high saturated fat, and high fructose recapitulates features of the metabolic syndrome and NASH with progressive fibrosis. This represents a novel small animal model of fibrosing NASH with high fidelity to the human condition. These results highlight the contribution of dietary composition to the development of nonalcoholic fatty liver disease and NASH.
C1 [Charlton, Michael; Krishnan, Anuradha; Viker, Kimberly; Cazanave, Sophie; McConico, Andrea; Masuoko, Howard; Gores, Gregory] Mayo Clin & Mayo Fdn, Div Gastroenterol & Hepatol, Rochester, MN 55905 USA.
   [Sanderson, Schuyler] Mayo Clin & Mayo Fdn, Div Anat Pathol, Rochester, MN 55905 USA.
C3 Mayo Clinic; Mayo Clinic
RP Charlton, M (corresponding author), Mayo Clin & Fdn CH 10, Div Gastroenterol & Hepatol, 200 1st St SW, Rochester, MN 55905 USA.
EM charlton.michael@mayo.edu
FU National Institute of Diabetes and Digestive and Kidney Diseases [RO1
   DK-41876, DK-069757-05]; Clinical Research Center [RR-00585]
FX This work has been supported by National Institute of Diabetes and
   Digestive and Kidney Diseases Grants RO1 DK-41876 (to G. Gomes) and
   DK-069757-05 (to M. Charlton) and General Clinical Research Center Grant
   RR-00585.
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NR 68
TC 330
Z9 354
U1 0
U2 27
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0193-1857
EI 1522-1547
J9 AM J PHYSIOL-GASTR L
JI Am. J. Physiol.-Gastroint. Liver Physiol.
PD NOV
PY 2011
VL 301
IS 5
BP G825
EP G834
DI 10.1152/ajpgi.00145.2011
PG 10
WC Gastroenterology & Hepatology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Physiology
GA 842IA
UT WOS:000296589500009
PM 21836057
OA Green Published
DA 2025-06-11
ER

PT J
AU Ma, JX
   Zhou, Y
   Wang, DM
   Guo, YJ
   Wang, B
   Xu, YJ
   Chen, WH
AF Ma, Jixuan
   Zhou, Yun
   Wang, Dongming
   Guo, Yanjun
   Wang, Bin
   Xu, Yiju
   Chen, Weihong
TI Associations between essential metals exposure and metabolic syndrome
   (MetS): Exploring the mediating role of systemic in flammation in a
   general Chinese population
SO ENVIRONMENT INTERNATIONAL
LA English
DT Article
DE Essential metal; Metabolic diseases; Systemic in flammation; -reactive
   protein
ID HEAVY-METALS; TRACE-ELEMENTS; CARDIOVASCULAR-DISEASE; OXIDATIVE STRESS;
   NATIONAL-HEALTH; ZINC SUPPLEMENTATION; INSULIN-RESISTANCE; PLASMA
   SELENIUM; URINARY METALS; UNITED-STATES
AB Background: Essential metals have been reported to be associated with metabolic diseases. However, the re- lationships between essential metals exposure and Metabolic Syndrome (MetS) is still uncertain, and the un- derlying mechanisms of the association remain unclear. Objectives: To investigate the associations of urinary essential metals with MetS prevalence; and further to ex- plore potential role of systemic in flammation biomarker, C-reactive protein (CRP), in relationships between essential metals exposure and MetS prevalence in a cross-sectional study. Methods: Concentrations of 8 urinary essential metals and plasma C-reactive protein (CRP) were quanti fied in 3272 adults from Wuhan-Zhuhai cohort. Urinary essential metals were adjusted by the corresponding urinary creatinine concentrations and reported as mu g/mmol creatinine. Multivariable logistic regression and linear re- gression models were used to evaluate dose-response relationships between essential metals, plasma CRP, and MetS prevalence. Mediation analysis was performed to investigate the role of plasma CRP in the associations between urinary essential metals and MetS prevalence. Results: In the single-metal models, we observed positive dose-dependent relationships of urinary copper and zinc with MetS prevalence. Compared with the lowest quartiles of urinary metals, the ORs (95% CI) of MetS in the highest quartiles were 1.40 (1.03, 1.91) for urinary copper and 2.07 (1.51, 2.84) for zinc, respectively. The dose-dependent relationships of zinc and copper with MetS remained signi ficant in the multiple-metal models and Bayesian kernel machine regression (BKMR) models. No signi ficant associations were observed between others essential metals (e.g. manganese, iron, cobalt, selenium, chromium, molybdenum) and MetS in this general population (all P value 0.05). In addition, urinary copper and zinc increased monotonically with plasma CRP elevation, and plasma CRP was positively associated with the MetS prevalence. Mediation analysis indicated that plasma CRP mediated 5.2% and 3.2% in the associations of urinary copper and zinc with MetS prevalence, respectively. Conclusions: Elevated concentrations of urinary copper and zinc were associated with increased prevalence of MetS. Systemic in flammation may play an important role in the associations of copper and zinc exposure with MetS.
C1 [Ma, Jixuan; Zhou, Yun; Wang, Dongming; Guo, Yanjun; Wang, Bin; Xu, Yiju; Chen, Weihong] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Dept Occupat & Environm Hlth, Wuhan 430030, Hubei, Peoples R China.
   [Ma, Jixuan; Zhou, Yun; Wang, Dongming; Guo, Yanjun; Wang, Bin; Xu, Yiju; Chen, Weihong] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Key Lab Environm & Hlth,Minist Educ, Wuhan 430030, Hubei, Peoples R China.
   [Ma, Jixuan; Zhou, Yun; Wang, Dongming; Guo, Yanjun; Wang, Bin; Xu, Yiju; Chen, Weihong] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Minist Environm Protect, Wuhan 430030, Hubei, Peoples R China.
   [Ma, Jixuan; Zhou, Yun; Wang, Dongming; Guo, Yanjun; Wang, Bin; Xu, Yiju; Chen, Weihong] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, State Key Lab Environm Hlth Incubating, Wuhan 430030, Hubei, Peoples R China.
C3 Huazhong University of Science & Technology; Huazhong University of
   Science & Technology; Ministry of Education - China; Huazhong University
   of Science & Technology; Huazhong University of Science & Technology
RP Chen, WH (corresponding author), Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Dept Occupat & Environm Hlth, Wuhan 430030, Hubei, Peoples R China.
EM wchen@mails.tjmu.edu.cn
RI Chen, Weihong/D-2177-2011
OI Wang, Bin/0000-0002-7166-0482; , Jixuan Ma/0000-0003-0644-0157
FU Key Program of the National Natural Science Foundation of China
   [91543207]; Fundamental Research Funds for the Central Universities
   [HUST 2016JCTD116, 2020kfyXJJS005]; China Postdoctoral Science
   Foundation [2019M652656]
FX This study was supported by the Key Program of the National Natural
   Science Foundation of China [grant number 91543207]; the Fundamental
   Research Funds for the Central Universities [grant number HUST
   2016JCTD116, 2020kfyXJJS005]; and the China Postdoctoral Science
   Foundation [grant number 2019M652656].
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NR 67
TC 58
Z9 60
U1 5
U2 58
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0160-4120
EI 1873-6750
J9 ENVIRON INT
JI Environ. Int.
PD JUL
PY 2020
VL 140
AR 105802
DI 10.1016/j.envint.2020.105802
PG 10
WC Environmental Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology
GA ME8CZ
UT WOS:000544882200005
PM 32474217
OA gold
DA 2025-06-11
ER

PT J
AU Li, M
   Fang, HJ
   Hu, J
AF Li, Meng
   Fang, Huijuan
   Hu, Jian
TI Apelin-13 ameliorates metabolic and cardiovascular disorders in a rat
   model of type 2 diabetes with a high-fat diet
SO MOLECULAR MEDICINE REPORTS
LA English
DT Article
DE Apelin-13; type 2 diabetes; high-fat diet; metabolic syndrome;
   Goto-Kakizaki rats; AMP-activated protein kinase
ID IMPROVES INSULIN-RESISTANCE; THERAPEUTIC TARGET; MELLITUS; DYSFUNCTION;
   SYSTEM; ENDOTHELIN-1; EXPRESSION; STRESS; GENE; ASSOCIATION
AB Apelin has been reported to be associated with multiple physiological processes in the cardiovascular system. The aim of the present study was to investigate the effects of Apelin-13 administration on cardiac function, hyperglycemia, insulin resistance (IR), dyslipidemia, endothelial function, inflammation and glucose metabolism in type 2 diabetic Goto-Kakizaki (GK) rats, and compare the protective effects of Apelin-13 with metformin or atorvastatin. In the present study, type 2 diabetes was induced in male Goto-Kakizaki (GK) rats fed with high-fat diet (HFD). Simultaneously, the rats were treated with metformin (350 mg/kg/d, by gavage), atorvastatin (50 mg/kg/d, by gavage) or Apelin-13 (200 mu g/kg/d, intraperitoneal injection) once daily for 4 consecutive weeks. Hemodynamic parameters were examined by RM6240BD multi-channel physiological signal monitoring. Fasting plasma glucose (FPG), fasting insulin (FINS), homeostasis model assessment for insulin resistance (HOMA-IR), total cholesterol (TC), triglyceride (TG), high density lipoprotein-cholesterol (HDL-C), low density lipoprotein-cholesterol (LDL-C), endothelin-1 (ET-1), nitric oxide (NO), constitutive nitric oxide synthase (cNOS) activity, tumor necrosis factor- (TNF-), leptin and Apelin-12 levels were measured. Western blotting was performed to determine the levels of Apelin-12, glucose transporter 4 (GLUT4) and phosphorylated (p)-5adenosine monophosphate-activated protein kinase (AMPK) 2. It was demonstrated that Apelin-13 decreased heart rate, left ventricular end-diastolic pressure, FPG, FINS, HOMA-IR, TC, TG, LDL-C, ET-1, TNF- and leptin, whereas it increased the rise and fall of maximum rate of left ventricular pressure, HDL-C, NO, cNOS activity and Apelin-12 compared with the GK-HFD group. In addition, GLUT4 and p-AMPK2 levels in myocardial tissues were elevated by administration of Apelin-13. This protective effect of Apelin-13 was comparable to that of metformin or atorvastatin. Overall, the present study demonstrated that administration of Apelin-13 may be a promising therapeutic agent for the treatment of type 2 diabetes and metabolic syndrome.
C1 [Li, Meng; Hu, Jian] China Med Univ, Affiliated Hosp 1, Dept Cardiol, 155 North Nanjing St, Shenyang 110001, Liaoning, Peoples R China.
   [Fang, Huijuan] Fourth Peoples Hosp Shenyang, Dept Cadre Ward, Shenyang 110031, Liaoning, Peoples R China.
C3 China Medical University
RP Hu, J (corresponding author), China Med Univ, Affiliated Hosp 1, Dept Cardiol, 155 North Nanjing St, Shenyang 110001, Liaoning, Peoples R China.
EM hujianyd2017@163.com
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NR 47
TC 21
Z9 22
U1 1
U2 11
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1791-2997
EI 1791-3004
J9 MOL MED REP
JI Mol. Med. Rep.
PD DEC
PY 2018
VL 18
IS 6
BP 5784
EP 5790
DI 10.3892/mmr.2018.9607
PG 7
WC Oncology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Research & Experimental Medicine
GA HA7DE
UT WOS:000450440600116
PM 30387843
OA Bronze
DA 2025-06-11
ER

PT J
AU Lytle, KA
   Wong, CP
   Jump, DB
AF Lytle, Kelli A.
   Wong, Carmen P.
   Jump, Donald B.
TI Docosahexaenoic acid blocks progression of western diet-induced
   nonalcoholic steatohepatitis in obese Ldlr<SUP>-/-</SUP> mice
SO PLOS ONE
LA English
DT Article
ID FATTY LIVER-DISEASE; TOLL-LIKE RECEPTORS; AMERICAN ASSOCIATION; HEPATIC
   INFLAMMATION; PRACTICE GUIDELINE; METABOLIC SYNDROME; NATURAL-HISTORY;
   GENE-EXPRESSION; WEIGHT-LOSS; N-3
AB Background
   Nonalcoholic fatty liver disease (NAFLD) is a major public health concern in western societies. Nonalcoholic steatohepatitis (NASH), the progressive form of NAFLD, is characterized by hepatic steatosis, inflammation, oxidative stress and fibrosis. NASH is a risk factor for cirrhosis and hepatocellular carcinoma. NASH is predicted to be the leading cause of liver transplants by 2020. Despite this growing public health concern, there remain no Food and Drug Administration (FDA) approved NASH treatments. Using Ldlr(-/-) mice as a preclinical model of western diet (WD)-induced NASH, we previously established that dietary supplementation with docosahexaenoic acid (DHA, 22:6,omega 3) attenuated WD-induced NASH in a prevention study. Herein, we evaluated the capacity of DHA supplementation of the WD and a low fat diet to fully reverse NASH in mice with pre-existing disease.
   Methods
   Ldlr(-/-) mice fed the WD for 22 wks developed metabolic syndrome (MetS) and a severe NASH phenotype, including obesity, dyslipidemia, hyperglycemia, hepatic steatosis, inflammation, fibrosis and low hepatic polyunsaturated fatty acid (PUFA) content. These mice were randomized to 5 groups: a baseline group (WDB, sacrificed at 22 wks) and 4 treatments: 1) WD + olive oil (WDO); 2) WD + DHA (WDD); 3) returned to chow + olive oil (WDChO); or 4) returned to chow + DHA (WDChD). The four treatment groups were maintained on their respective diets for 8 wks. An additional group was maintained on standard laboratory chow (Reference Diet, RD) for the 30-wk duration of the study.
   Results
   When compared to the WDB group, the WDO group displayed increased hepatic expression of genes linked to inflammation (Opn, Il1rn, Gdf15), hepatic fibrosis (collagen staining, Col1A1, Thbs2, Lox) reflecting disease progression. Mice in the WDD group, in contrast, had increased hepatic C20-22 omega 3 PUFA and no evidence of NASH progression. MetS and NASH markers in the WDChO or WDChD groups were significantly attenuated and marginally different from the RD group, reflecting disease remission.
   Conclusion
   While these studies establish that DHA supplementation of the WD blocks WD-induced NASH progression, DHA alone does not promote full remission of diet-induced MetS or NASH.
C1 [Lytle, Kelli A.; Wong, Carmen P.; Jump, Donald B.] Oregon State Univ, Sch Biol & Populat Hlth Sci, Nutr Program, Corvallis, OR 97331 USA.
   [Lytle, Kelli A.; Wong, Carmen P.; Jump, Donald B.] Oregon State Univ, Linus Pauling Inst, Corvallis, OR 97331 USA.
   [Lytle, Kelli A.] Mayo Clin, Endocrine Res Unit, Rochester, MN USA.
C3 Oregon State University; Oregon State University; Mayo Clinic
RP Jump, DB (corresponding author), Oregon State Univ, Sch Biol & Populat Hlth Sci, Nutr Program, Corvallis, OR 97331 USA.; Jump, DB (corresponding author), Oregon State Univ, Linus Pauling Inst, Corvallis, OR 97331 USA.
EM Donald.Jump@oregonstate.edu
FU USDA; National Institute of Food and Agriculture Grant
   [2009-65200-05846]; National Institutes of Health [DK 094600]
FX This research was supported by the USDA, National Institute of Food and
   Agriculture Grant (2009-65200-05846) and the National Institutes of
   Health (DK 094600). The funders had no role in the study design, data
   collections and analysis, decision to publish, or preparation of the
   manuscript.
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NR 99
TC 46
Z9 47
U1 0
U2 10
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD APR 19
PY 2017
VL 12
IS 4
AR e0173376
DI 10.1371/journal.pone.0173376
PG 26
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA ES9KK
UT WOS:000399875600008
PM 28422962
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Hsu, SH
   Syu, DK
   Chen, YC
   Liu, CK
   Sun, CA
   Chen, MC
AF Hsu, Shu-Hua
   Syu, De-Kai
   Chen, Yong-Chen
   Liu, Chih-Kuang
   Sun, Chien-An
   Chen, Mingchih
TI The Association between Hypertriglyceridemia and Colorectal Cancer: A
   Long-Term Community Cohort Study in Taiwan
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Article
DE hypertriglyceridemia; colorectal cancer; diabetes mellitus
ID METABOLIC SYNDROME; SERUM-CHOLESTEROL; CARDIOVASCULAR-DISEASE; RISK;
   OBESITY; LIPIDS; DYSLIPIDEMIA; MORTALITY; GLUCOSE; HYPERLIPIDEMIA
AB (1) Background: Colorectal cancer (CRC) is the third most common malignancy and the second leading cause of cancer deaths worldwide. It often diagnosed at advanced stages, and with increasing incidence at younger generation. CRC poses a heavy financial burden and a huge public health challenge nowadays. Lipoproteins and serum lipids may have an influence on carcinogenesis by making oxidative stress, inflammation, and insulin resistance. Dyslipidemia plays a potential role in the risk of CRC. The purpose of this study is to use nationally representative samples to determine epidemiologic characteristics of CRC in the Taiwanese population, and to evaluate the associations between baseline levels of lipid profile and their effect on risk of colorectal cancer (CRC) comprehensively and quantitatively. The control of dyslipidemia in primary and secondary prevention may reduce the disease burden of CRC. (2) Methods: This is a nationwide long-term community-based prospective cohort study. Data were retrieved from the nationwide population-based Taiwanese Survey on Hypertension, Hyperglycemia and Hyperlipidemia (TwSHHH). Variables were estimated by the Cox proportional hazards model which was then further adjusted for age. We also calculated the relative ratios (RRs) of CRC for joint categories of serum cholesterol, triglyceride (TG), low-density lipoproteins cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) level, and to examine their combined effect and statistical interactions. (3) Results: Male, age, waist circumference, diabetes mellitus (DM), high TG, high cholesterol level, smoking history, and metabolic syndrome were proved to increase the risk of CRC. In addition, DM patients with a TG level >= 150 mg/dL and cholesterol >= 180 mg/dL had a 4.118-fold higher risk of CRC as compared with a TG level <150 mg/dL and cholesterol level <180 mg/dL, which was a significant difference (95% CI, 1.061-15.975; p = 0.0407). (4) Conclusions: Patients with DM should control TG and cholesterol level through diet, exercise, or taking medications more aggressively, not only for preventing cardiovascular disease, but also for first prevention of CRC. The study can be valuable for the clinicians and policy makers to implement more precisely goals about dyslipidemia management.
C1 [Hsu, Shu-Hua] Fu Jen Catholic Univ, Fu Jen Catholic Univ Hosp, Dept Family Med, Guizi Rd 69, New Taipei 24352, Taiwan.
   [Hsu, Shu-Hua; Liu, Chih-Kuang; Chen, Mingchih] Fu Jen Catholic Univ, Coll Management, Grad Inst Business Adm, 510 Zhongzheng Rd, New Taipei 242062, Taiwan.
   [Syu, De-Kai] Fu Jen Catholic Univ, Fu Jen Catholic Univ Hosp, Dept Orthoped, 69 Guizi Rd, New Taipei 24352, Taiwan.
   [Chen, Yong-Chen] Fu Jen Catholic Univ, Coll Med, Master Program Big Data Biomed, 510 Zhongzheng Rd, New Taipei 242062, Taiwan.
   [Chen, Yong-Chen; Sun, Chien-An] Fu Jen Catholic Univ, Coll Med, Data Sci Ctr, 510 Zhongzheng Rd, New Taipei 242062, Taiwan.
   [Liu, Chih-Kuang] Fu Jen Catholic Univ, Fu Jen Catholic Univ Hosp, Dept Urol, 69 Guizi Rd, New Taipei 24352, Taiwan.
   [Sun, Chien-An] Fu Jen Catholic Univ, Coll Med, Dept Publ Hlth, New Taipei 24205, Taiwan.
   [Chen, Mingchih] Fu Jen Catholic Univ, Artificial Intelligence Dev Ctr, 510 Zhongzheng Rd, New Taipei 242062, Taiwan.
C3 Fu Jen Catholic University; Fu Jen Catholic University Hospital; Fu Jen
   Catholic University; Fu Jen Catholic University; Fu Jen Catholic
   University Hospital; Fu Jen Catholic University; Fu Jen Catholic
   University; Fu Jen Catholic University; Fu Jen Catholic University
   Hospital; Fu Jen Catholic University; Fu Jen Catholic University
RP Chen, MC (corresponding author), Fu Jen Catholic Univ, Coll Management, Grad Inst Business Adm, 510 Zhongzheng Rd, New Taipei 242062, Taiwan.; Sun, CA (corresponding author), Fu Jen Catholic Univ, Coll Med, Data Sci Ctr, 510 Zhongzheng Rd, New Taipei 242062, Taiwan.; Sun, CA (corresponding author), Fu Jen Catholic Univ, Coll Med, Dept Publ Hlth, New Taipei 24205, Taiwan.; Chen, MC (corresponding author), Fu Jen Catholic Univ, Artificial Intelligence Dev Ctr, 510 Zhongzheng Rd, New Taipei 242062, Taiwan.
EM crazysunnyhsu@gmail.com; gladiator711124@gmail.com;
   137159@mail.fju.edu.tw; 059435@mail.fju.edu.tw; 040866@mail.fju.edu.tw;
   081438@mail.fju.edu.tw
RI Hsu, Shuhua/AAG-1370-2020; Chen, Yong-Chen/KIK-1812-2024
OI Chen, Yong-Chen/0000-0003-1007-3003; Sun, Chien-An/0000-0001-9041-0537
FU Fu Jen Catholic University [A0110183]
FX This research was funded by Fu Jen Catholic University (A0110183).
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NR 70
TC 9
Z9 9
U1 1
U2 5
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD JUL
PY 2022
VL 19
IS 13
AR 7804
DI 10.3390/ijerph19137804
PG 12
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA 2W3WK
UT WOS:000824457900001
PM 35805464
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Semmler, G
   Bachmayer, S
   Wernly, S
   Wernly, B
   Niederseer, D
   Huber-Schönauer, U
   Stickel, F
   Aigner, E
   Datz, C
AF Semmler, Georg
   Bachmayer, Sebastian
   Wernly, Sarah
   Wernly, Bernhard
   Niederseer, David
   Huber-Schonauer, Ursula
   Stickel, Felix
   Aigner, Elmar
   Datz, Christian
TI Nut consumption and the prevalence and severity of non-alcoholic fatty
   liver disease
SO PLOS ONE
LA English
DT Article
ID RELATIVE VALIDITY; GERMAN PART; RISK; NAFLD; DIET; REPRODUCIBILITY;
   ASSOCIATIONS; INFLAMMATION; FIBROSIS; HEALTH
AB Background
   Nut consumption has been associated with reduced inflammation, insulin resistance, and oxidative stress. However, the influence on the prevalence and severity of non-alcoholic fatty liver disease (NAFLD) has yet to be evaluated.
   Methods
   4655 subjects were included as part of a colorectal carcinoma screening program (SAKKOPI) between 07/2010 and 07/2019 and analyzed 2020. Patients were characterized using biochemical and metabolic parameters, as well as a detailed questionnaire on dietary habits. The diagnosis of NAFLD was established using abdominal ultrasound. Consumption of nuts was graded as: no consumption or <1 time/week, 1-6 times/week, 1 time/day and >= 2 times/day.
   Results
   Mean age was 58.5 +/- 9.8years with a mean BMI of 26.5 +/- 4.7kg/m(2). 2058 (44.2%) patients suffered from the metabolic syndrome, 2407 (51.6%) had arterial hypertension, 2287 (49.1%) showed prediabetes/diabetes, 1854 (39.4%) had dyslipidemia and 1984 patients (43.5%) were diagnosed with NAFLD. Prevalence of metabolic syndrome (1219 [48.7%] vs. 605 [40.2%] vs. 189 [37.4%] vs. 45 [31.7%], p<0.001) and NALFD (1184 [48.1%] vs. 594 [40.7%] vs. 158 [31.7%] vs. 48 [34.0%], p<0.001). On multivariable logistic regression analysis adjusting for potential confounders and dietary patterns, nut consumption >= 1time/day was inversely associated with NAFLD in the overall cohort (adjusted Odds ratio[aOR]: 0.719 [95%CI:0.558-0.926], p = 0.011). However, following subgroup analysis, this inverse association was only confirmed in male patients (aOR: 0.589 [95%CI: 0.411-0.844], p = 0.004) but not in females (aOR: 0.886 [95%CI: 0.616-1.275], p = 0.515). Moreover, patients who consumed nuts 1-6 times/week had a significantly lower prevalence of advanced fibrosis (Fib-4 score >2.67: aOR: 0.551 [95%CI: 0.338-0.898], p = 0.017; Forns-Index >6.9: aOR: 0.585 [95%CI: 0.402-0.850], p = 0.005).
   Conclusions
   Nut consumption might exert beneficial effects on the prevalence of NAFLD in males. The negative association with advanced fibrosis warrants further investigation.
C1 [Semmler, Georg; Bachmayer, Sebastian; Wernly, Sarah; Huber-Schonauer, Ursula; Datz, Christian] Paracelsus Med Univ Salzburg, Teaching Hosp, Gen Hosp Oberndorf, Dept Internal Med, Salzburg, Austria.
   [Wernly, Bernhard] Paracelsus Med Univ Salzburg, Dept Med 2, Salzburg, Austria.
   [Niederseer, David] Univ Hosp Zurich, Dept Cardiol, Zurich, Switzerland.
   [Stickel, Felix] Univ Hosp Zurich, Dept Gastroenterol & Hepatol, Zurich, Switzerland.
   [Aigner, Elmar] Paracelsus Med Univ Salzburg, Dept Med 1, Salzburg, Austria.
C3 Paracelsus Private Medical University; Paracelsus Private Medical
   University; University of Zurich; University Zurich Hospital; University
   of Zurich; University Zurich Hospital; Paracelsus Private Medical
   University
RP Datz, C (corresponding author), Paracelsus Med Univ Salzburg, Teaching Hosp, Gen Hosp Oberndorf, Dept Internal Med, Salzburg, Austria.
EM c.datz@kh-oberndorf.at
RI Semmler, Georg/O-3323-2019; Wernly, Bernhard/AAA-8529-2020; Niederseer,
   David/B-6203-2008
OI Reiberger, Thomas/0000-0002-4590-3583; Semmler,
   Georg/0000-0002-0411-166X; Huber-Schonauer, Ursula/0000-0003-4674-6230
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NR 63
TC 14
Z9 14
U1 0
U2 4
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD DEC 31
PY 2020
VL 15
IS 12
AR e0244514
DI 10.1371/journal.pone.0244514
PG 13
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA PP1TW
UT WOS:000605651900003
PM 33382757
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Chang, ST
   Chu, CM
   Hsu, JT
   Hsiao, JF
   Chung, CM
   Ho, C
   Peng, YS
   Chen, PY
   Shee, JJ
AF Chang, Shih-Tai
   Chu, Chi-Ming
   Hsu, Jen-Te
   Hsiao, Ju-Feng
   Chung, Chang-Min
   Ho, Cheng
   Peng, Yun-Shing
   Chen, Pao-Yin
   Shee, Jia-Jen
TI Independent Determinants of Coronary Artery Disease in Erectile
   Dysfunction Patients
SO JOURNAL OF SEXUAL MEDICINE
LA English
DT Article
DE Erectile Dysfunction; Coronary Artery Disease; Metabolic Syndrome;
   Inflammatory Marker; Obesity; Cardiovascular Risk Factors for Erectile
   Dysfunction
ID INTIMA-MEDIA THICKNESS; ISCHEMIC-HEART-DISEASE; RISK-FACTORS; PULSE
   PRESSURE; SUBCLINICAL ATHEROSCLEROSIS; MYOCARDIAL-INFARCTION; ADHESION
   MOLECULES; DIABETIC-PATIENTS; BLOOD-FLOW; MEN
AB Introduction.
   There is growing evidence of a link between erectile dysfunction (ED) and coronary artery disease (CAD).
   Aims.
   The purpose of this study was to explore the independent determinants of CAD in ED outpatients.
   Methods.
   This study enrolled 243 patients, ranging in age from 21 to 81 years old, suffering from ED as diagnosed by the International Index of Erectile Function (IIEF) scores. All patients underwent exercise stress tests or thallium-201 single-photon emission computed tomography perfusion imagings. Based on examination results, patients were divided into study (22 patients with a positive finding) and control groups (221 patients with a negative finding).
   Main Outcome Measures.
   The differences of demographic characteristics, biochemical profiles, pro-inflammatory and inflammatory markers, and echocardiographic characteristics between study and control group were compared.
   Results.
   The age, presence of DM and current smoking status were significant high in the study group. A significant lower high-density lipoprotein (HDL) cholesterol level, a higher percentage of HDL cholesterol level < 40 mg/dL, and a higher apo-lipoprotein B/A1, high sensitive C-reactive protein (hs-CRP) and homocysteine found in the study group. The Framingham cardiac risk scores, the ratio of mitral inflow velocity to early diastolic velocity in the annulus derived by tissue Doppler imaging (E/Et), the ratio of E/Et >= 15, the value of carotid intima-media thickness (IMT), and IMT >= 1 mm were higher in study group than in the control group. In stepwise multiple logistic regression analysis, a high waist-to-hip ratio (WHR), high IMT, high E/Et, hs-CRP levels, LDL cholesterol >= 130 mg/dL, smoking status, and the presence of DM and metabolic syndrome (MS) were independent determinants of CAD in ED patients.
   Conclusions.
   This study first shows the independent determinants of CAD in ED outpatients. This novel finding may improve the screening of low-risk ED patients for CAD. Chang S-T, Chu C-M, Hsu J-T, Hsiao J-F, Chung C-M, Ho C, Peng Y-S, Chen P-Y, and Shee J-J. Independent determinants of coronary artery disease in erectile dysfunction patients. J Sex Med 2010;7:1478-1487.
C1 [Shee, Jia-Jen] Chiayi Chang Gung Mem Hosp, Div Urol, Chai Yi Hsien, Taiwan.
   [Chang, Shih-Tai; Hsu, Jen-Te; Hsiao, Ju-Feng; Chung, Chang-Min; Peng, Yun-Shing; Chen, Pao-Yin; Shee, Jia-Jen] Chang Gung Inst Technol, Chiayi Sch, Chai Yi Hsien, Taiwan.
   [Chang, Shih-Tai; Hsu, Jen-Te; Hsiao, Ju-Feng; Chung, Chang-Min; Peng, Yun-Shing; Chen, Pao-Yin; Shee, Jia-Jen] Chang Gung Univ, Coll Med, Tao Yuan, Taiwan.
   [Chang, Shih-Tai; Hsu, Jen-Te; Hsiao, Ju-Feng; Chung, Chang-Min] Chiayi Chang Gung Mem Hosp, Div Cardiol, Chai Yi Hsien, Taiwan.
   [Chu, Chi-Ming; Ho, Cheng] Natl Def Med Ctr & Univ, Inst Publ Hlth, Sect Hlth Informat, Taipei, Taiwan.
   [Peng, Yun-Shing; Chen, Pao-Yin] Chiayi Chang Gung Mem Hosp, Div Endocrinol & Metab, Chai Yi Hsien, Taiwan.
C3 Chang Gung Memorial Hospital; Chang Gung University of Science &
   Technology; Chang Gung University; Chang Gung Memorial Hospital;
   National Defense Medical Center; Chang Gung Memorial Hospital
RP Shee, JJ (corresponding author), Chiayi Chang Gung Mem Hosp, Div Urol, 6 Sec W Chai Pu Rd, Pu Tz City, Chai Yi Hsien, Taiwan.
EM cst1234567@yahoo.com.tw
RI Cheng, Hao-Wen/AAI-6298-2021; Chu, Christopher/HHN-4195-2022
OI Chu, Cordia/0000-0002-3683-5638
FU Chang Gung Memorial Hospital Chiayi/Taiwan [CMRPG 650131]
FX The authors would like to thank Chang Gung Memorial Hospital for
   financially supporting this research under Contract No. CMRPG 650131
   Chiayi/Taiwan
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NR 48
TC 21
Z9 23
U1 0
U2 5
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1743-6095
EI 1743-6109
J9 J SEX MED
JI J. Sex. Med.
PD APR
PY 2010
VL 7
IS 4
BP 1478
EP 1487
DI 10.1111/j.1743-6109.2009.01562.x
PN 1
PG 10
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 580RW
UT WOS:000276468300017
PM 19878446
DA 2025-06-11
ER

PT J
AU Thamer, C
   Tschritter, O
   Haap, M
   Shirkavand, F
   Machann, J
   Fritsche, A
   Schick, F
   Häring, H
   Stumvoll, M
AF Thamer, C
   Tschritter, O
   Haap, M
   Shirkavand, F
   Machann, J
   Fritsche, A
   Schick, F
   Häring, H
   Stumvoll, M
TI Elevated serum GGT concentrations predict reduced insulin sensitivity
   and increased intrahepatic lipids
SO HORMONE AND METABOLIC RESEARCH
LA English
DT Article
DE intrahepatic lipids; type 2 diabetes; insulin resistance; obesity;
   gamma-glutamyltransferase
ID GAMMA-GLUTAMYL-TRANSFERASE; METABOLIC SYNDROME; DIABETES-MELLITUS;
   OXIDATIVE STRESS; LIVER; RISK; TRANSPEPTIDASE; RESISTANCE; OBESITY; MEN
AB Elevated serum gamma-glutamyltransferase (GGT) concentrations have been related to features of the metabolic syndrome as well as increased risk of cardiovascular and liver disease. More recently, elevated GGT levels were shown to predict development of type 2 diabetes in a longitudinal study from Korea. The aim of the present study was to test the hypothesis that serum GGT is associated with glucose tolerance, insulin sensitivity and beta-cell function in a healthy, non-diabetic Caucasian population from the Tubingen family study. Insulin sensitivity was estimated by oGTT (n = 850) or measured by hyperinsulinemic euglycemic clamp (n = 245), respectively. A subgroup (n = 70) underwent additional determination of intrahepatic lipid content using H-1 magnetic resonance spectroscopy. Serum GGT was positively correlated with two-hour glucose during oGTT (r=0.15, p &LT; 0.0001) and negatively correlated with insulin sensitivity from oGTT (r=-0.31, p&LT; 0.0001) and clamp (r=-0.27, p &LT; 0.0001). The relationship between GGT and insulin sensitivity remained significant after adjusting for sex, age, BMI, and AST using multivariate regression analysis. Inclusion of serum triglyceride levels as a parameter of lipid metabolism kept the relationship significant in the oGTT group (p &LT; 0.0001), but not in the smaller clamp group (p = 0.11). Additionally, serum GGT was positively correlated with hepatic lipid content (r=0.49, p &LT; 0.001) independent of sex, age, BMI, AST or serum triglycerides. There was no significant correlation between GGT and the index for beta-cell function after adjusting for age, sex, BMI and insulin sensitivity (p = 0.74). In conclusion, elevated serum GGT levels predict glucose intolerance probably via insulin resistance rather than beta-cell dysfunction. This may be primarily related to hepatic insulin resistance and increased intrahepatic lipids. The association observed between elevated hepatic lipids and reduced insulin sensitivity might explain the increased diabetes risk observed in subjects with elevated serum GIST concentrations. In the absence of overt liver disease, elevated serum GIST concentrations may point the clinician to incipient disturbances in the glucose metabolism.
C1 Univ Tubingen, Dept Endocrinol & Metab, Tubingen, Germany.
   Univ Tubingen, Dept Diagnost Radiol, Sect Expt Radiol, Tubingen, Germany.
   Univ Leipzig, Dept Med 3, Leipzig, Germany.
C3 Eberhard Karls University of Tubingen; Eberhard Karls University of
   Tubingen; Eberhard Karls University Hospital; Leipzig University
RP Thamer, C (corresponding author), Med Univ Klin, Otfried Muller Str 10, D-72076 Tubingen, Germany.
EM claus.thamer@med.uni-tuebingen.de
RI Stumvoll, Michael/ABE-1121-2021
OI Schick, Fritz/0000-0002-4231-3406; Stumvoll, Michael/0000-0001-6225-8240
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NR 22
TC 85
Z9 92
U1 0
U2 12
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0018-5043
J9 HORM METAB RES
JI Horm. Metab. Res.
PD APR
PY 2005
VL 37
IS 4
BP 246
EP 251
DI 10.1055/s-2005-861411
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 931WD
UT WOS:000229515300011
PM 15952086
DA 2025-06-11
ER

PT J
AU Oliveira, AL
   de Oliveira, MG
   Monica, FZ
   Antunes, E
AF Oliveira, Akila Lara
   de Oliveira, Mariana Goncalves
   Monica, Fabiola Zakia
   Antunes, Edson
TI Methylglyoxal and Advanced Glycation End Products (AGEs): Targets for
   the Prevention and Treatment of Diabetes-Associated Bladder Dysfunction?
SO BIOMEDICINES
LA English
DT Review
DE dicarbonyl stress; RAGE; oxidative stress; polyphenols; metformin;
   alagebrium
ID URINARY-TRACT SYMPTOMS; BENIGN PROSTATIC HYPERPLASIA; POPULATION-BASED
   SURVEY; DETRUSOR SMOOTH-MUSCLE; TIME-DEPENDENT CHANGES; OVERACTIVE
   BLADDER; METABOLIC SYNDROME; OXIDATIVE STRESS; ERECTILE DYSFUNCTION;
   UNDERACTIVE BLADDER
AB Methylglyoxal (MGO) is a highly reactive alpha-dicarbonyl compound formed endogenously from 3-carbon glycolytic intermediates. Methylglyoxal accumulated in plasma and urine of hyperglycemic and diabetic individuals acts as a potent peptide glycation molecule, giving rise to advanced glycation end products (AGEs) like arginine-derived hydroimidazolone (MG-H1) and carboxyethyl-lysine (CEL). Methylglyoxal-derived AGEs exert their effects mostly via activation of RAGE, a cell surface receptor that initiates multiple intracellular signaling pathways, favoring a pro-oxidant environment through NADPH oxidase activation and generation of high levels of reactive oxygen species (ROS). Diabetic bladder dysfunction is a bothersome urological complication in patients with poorly controlled diabetes mellitus and may comprise overactive bladder, urge incontinence, poor emptying, dribbling, incomplete emptying of the bladder, and urinary retention. Preclinical models of type 1 and type 2 diabetes have further confirmed the relationship between diabetes and voiding dysfunction. Interestingly, healthy mice supplemented with MGO for prolonged periods exhibit in vivo and in vitro bladder dysfunction, which is accompanied by increased AGE formation and RAGE expression, as well as by ROS overproduction in bladder tissues. Drugs reported to scavenge MGO and to inactivate AGEs like metformin, polyphenols, and alagebrium (ALT-711) have shown favorable outcomes on bladder dysfunction in diabetic obese leptin-deficient and MGO-exposed mice. Therefore, MGO, AGEs, and RAGE levels may be critically involved in the pathogenesis of bladder dysfunction in diabetic individuals. However, there are no clinical trials designed to test drugs that selectively inhibit the MGO-AGEs-RAGE signaling, aiming to reduce the manifestations of diabetes-associated bladder dysfunction. This review summarizes the current literature on the role of MGO-AGEs-RAGE-ROS axis in diabetes-associated bladder dysfunction. Drugs that directly inactivate MGO and ameliorate bladder dysfunction are also reviewed here.
C1 [Oliveira, Akila Lara; de Oliveira, Mariana Goncalves; Monica, Fabiola Zakia; Antunes, Edson] Univ Campinas UNICAMP, Fac Med Sci, Dept Translat Med, Pharmacol Area, BR-13084971 Campinas, SP, Brazil.
C3 Universidade Estadual de Campinas
RP Antunes, E (corresponding author), Univ Campinas UNICAMP, Fac Med Sci, Dept Translat Med, Pharmacol Area, BR-13084971 Campinas, SP, Brazil.
EM a192906@dac.unicamp.br; marigo@unicamp.br; fzm@unicamp.br;
   eantunes@unicamp.br
RI Oliveira, Akila/HZJ-0189-2023; Antunes, Edson/KRP-5678-2024; Monica,
   Fabiola/B-4191-2013; ANTUNES, EDSON/F-6731-2012; de Oliveira, Mariana
   G/D-2059-2016
OI ANTUNES, EDSON/0000-0003-2201-8247; de Oliveira, Mariana
   G/0000-0003-2226-2530
FU Fundao de Amparo Pesquisa do Estado de So Paulo
FX No Statement Available
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NR 220
TC 11
Z9 11
U1 1
U2 5
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2227-9059
J9 BIOMEDICINES
JI Biomedicines
PD MAY
PY 2024
VL 12
IS 5
AR 939
DI 10.3390/biomedicines12050939
PG 22
WC Biochemistry & Molecular Biology; Medicine, Research & Experimental;
   Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Research & Experimental Medicine;
   Pharmacology & Pharmacy
GA SC9A3
UT WOS:001232364500001
PM 38790901
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Amin, SN
   Asali, F
   Aolymat, I
   Abuquteish, D
   Abu Al Karsaneh, O
   El Gazzar, WB
   Shaltout, SA
   Alabdallat, YJ
   Elberry, DA
   Kamar, SS
   Hosny, SA
   Mehesen, MN
   Rashed, LA
   Farag, AM
   ShamsEldeen, AM
AF Amin, Shaimaa Nasr
   Asali, Fida
   Aolymat, Iman
   Abuquteish, Dua
   Abu Al Karsaneh, Ola
   El Gazzar, Walaa Bayoumie
   Shaltout, Sherif Ahmed
   Alabdallat, Yasmeen Jamal
   Elberry, Dalia Azmy
   Kamar, Samaa Samir
   Hosny, Sara Adel
   Mehesen, Marwa Nagi
   Rashed, Laila Ahmed
   Farag, Ayman Mohamed
   ShamsEldeen, Asmaa Mohammed
TI Comparing MitoQ10 and heat therapy: Evaluating mechanisms and
   therapeutic potential for polycystic ovary syndrome induced by circadian
   rhythm disruption
SO CHRONOBIOLOGY INTERNATIONAL
LA English
DT Article
DE PCOS; oxidative stress; circadian rhythm; reproductive function; FKBP52;
   Fibulin-1; ADAMTS-19; >
ID ANTI-MULLERIAN HORMONE; MITOCHONDRIA-TARGETED ANTIOXIDANT; MESSENGER-RNA
   EXPRESSION; RAT MODEL; INSULIN-RESISTANCE; PROGESTERONE-RECEPTOR;
   LIPID-PEROXIDATION; METABOLIC SYNDROME; IMPROVES GLUCOSE; OXIDATIVE
   STRESS
AB Environmental factors, such as sleep restriction, contribute to polycystic ovary syndrome (PCOS) by causing hyperinsulinemia, hyperandrogenism, insulin resistance, and oligo- or anovulation. This study aimed to evaluate the effects of circadian rhythm disruption on reproductive and metabolic functions and investigate the potential therapeutic benefits of MitoQ10 and hot tub therapy (HTT). Sixty female rats were divided into six groups: control, MitoQ10, HTT, and three groups with PCOS induced by continuous light exposure(L/L). The reproductive, endocrine, and structural manifestations ofL/L-induced PCOS were confirmed by serum biochemical measurements, ultrasound evaluation of ovarian size, and vaginal smear examination at week 14. Subsequently, the rats were divided into the L/L (untreated), L/L+MitoQ10-treated, andL/L+HTT-treated groups. At the end of week 22, all rats were sacrificed. Treatmentwith MitoQ10 or HTT partially reversed the reproductive, endocrine, and structural features of PCOS, leading to a decreased amplitude of isolated uterine contractions, ovarian cystic changes and size, and endometrial thickness. Furthermore, both interventions improved the elevated serum levels of anti-Mullerian hormone (AMH), kisspeptin, Fibulin-1, A disintegrin and metalloproteinase with thrombospondin motifs 19 (ADAMTS-19), lipid profile, homeostatic model assessment for insulin resistance (HOMA-IR), oxidative stress markers, androgen receptors (AR) and their transcription target genes, FKBP52 immunostaining in ovarian tissues, and uterine estrogen receptor alpha (ER-& alpha;) and PRimmunostaining. In conclusion, MitoQ10 supplementation and HTT demonstrated the potential for ameliorating metabolic, reproductive, and structural perturbations associated with PCOS induced by circadian rhythm disruption. These findings suggest a potential therapeutic role for these interventions in managing PCOS in women.
C1 [Amin, Shaimaa Nasr; Aolymat, Iman; El Gazzar, Walaa Bayoumie] Hashemite Univ, Fac Med, Dept Anat Physiol & Biochem, POB 330127, Zarqa 13133, Jordan.
   [Amin, Shaimaa Nasr; Elberry, Dalia Azmy; ShamsEldeen, Asmaa Mohammed] Cairo Univ, Fac Med, Dept Physiol, Cairo, Egypt.
   [Asali, Fida] Hashemite Univ, Fac Med, Dept Obstet & Gynaecol, POB 330127, Zarqa 13133, Jordan.
   [Abuquteish, Dua; Abu Al Karsaneh, Ola] Hashemite Univ, Fac Med, Dept Microbiol Pathol & Forens Med, POB 330127, Zarqa 13133, Jordan.
   [El Gazzar, Walaa Bayoumie] Benha Univ, Fac Med, Dept Med Biochem & Mol Biol, Banha, Egypt.
   [Shaltout, Sherif Ahmed] Hashemite Univ, Fac Med, Dept Pharmacol Publ Hlth & Clin Skills, POB 330127, Zarqa 13133, Jordan.
   [Shaltout, Sherif Ahmed] Benha Univ, Fac Med, Dept Pharmacol, Banha, Egypt.
   [Alabdallat, Yasmeen Jamal] Hashemite Univ, Fac Med, Zarqa, Jordan.
   [Kamar, Samaa Samir; Hosny, Sara Adel] Cairo Univ, Fac Med, Dept Histol, Cairo, Egypt.
   [Kamar, Samaa Samir] Armed Forces Coll Med, Dept Histol, Cairo, Egypt.
   [Hosny, Sara Adel] Nahda Univ, Fac Med, Dept Histol & Cell Biol, Bani Suwayf, Egypt.
   [Mehesen, Marwa Nagi] Cairo Univ, Fac Med, Dept Med Pharmacol, Cairo, Egypt.
   [Mehesen, Marwa Nagi] Future Univ Egypt, Fac Pharm, Dept Pharm Practice & Clin Pharm, Cairo, Egypt.
   [Rashed, Laila Ahmed] Cairo Univ, Fac Med, Dept Biochem, Cairo, Egypt.
   [Farag, Ayman Mohamed] Mil Med Acad, Radiol Dept, Cairo, Egypt.
   [ShamsEldeen, Asmaa Mohammed] October 6 Univ, Fac Med, Dept Physiol, Cairo, Egypt.
   [Abuquteish, Dua] King Hussein Canc Ctr, Dept Pathol & Lab Med, Amman, Jordan.
C3 Hashemite University; Egyptian Knowledge Bank (EKB); Cairo University;
   Hashemite University; Hashemite University; Egyptian Knowledge Bank
   (EKB); Benha University; Hashemite University; Egyptian Knowledge Bank
   (EKB); Benha University; Hashemite University; Egyptian Knowledge Bank
   (EKB); Cairo University; Armed Forces College of Medicine (AFCM);
   Egyptian Knowledge Bank (EKB); Cairo University; Egyptian Knowledge Bank
   (EKB); Future University in Egypt; Egyptian Knowledge Bank (EKB); Cairo
   University; Egyptian Knowledge Bank (EKB); October 6 University (O6U);
   King Hussein Cancer Center
RP Amin, SN (corresponding author), Hashemite Univ, Fac Med, Dept Anat Physiol & Biochem, POB 330127, Zarqa 13133, Jordan.
EM shaimaa@hu.edu.jo
RI el gazzar, walaa/KMA-5855-2024; Asali, Fida/ABA-3727-2020; Kamar,
   Samaa/W-1137-2019; Mehesen, Marwa/AAC-3712-2022; Shamseldeen,
   Asmaa/AAR-2357-2020; Alabdallat, Yasmeen/AAW-8057-2021; Amin,
   Shaimaa/B-2764-2015
OI ShamsEldeen, Asmaa/0000-0002-4250-0818; Abu Al Karsaneh,
   Ola/0000-0001-6064-2548; Asali, Fida/0000-0003-3122-9898; Mehesen,
   Marwa/0000-0002-4515-8691; Aolymat, Iman/0000-0002-1231-1071; el gazzar,
   walaa/0000-0001-5172-1105; Alabdallat, Yasmeen/0000-0001-6855-3718;
   Abuquteish, Dua/0000-0001-7269-7853; kamar, Samaa/0000-0002-9040-584X
FU Hashemite University [59/2020]
FX The work was supported by the~Hashemite University [59/2020].
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NR 115
TC 3
Z9 3
U1 0
U2 0
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 0742-0528
EI 1525-6073
J9 CHRONOBIOL INT
JI Chronobiol. Int.
PD AUG 3
PY 2023
VL 40
IS 8
BP 1004
EP 1027
DI 10.1080/07420528.2023.2241902
EA AUG 2023
PG 24
WC Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics; Physiology
GA S1NV6
UT WOS:001042501600001
PM 37548004
DA 2025-06-11
ER

PT J
AU Koklesova, L
   Mazurakova, A
   Samec, M
   Kudela, E
   Biringer, K
   Kubatka, P
   Golubnitschaja, O
AF Koklesova, Lenka
   Mazurakova, Alena
   Samec, Marek
   Kudela, Erik
   Biringer, Kamil
   Kubatka, Peter
   Golubnitschaja, Olga
TI Mitochondrial health quality control: measurements and interpretation in
   the framework of predictive, preventive, and personalized medicine
SO EPMA JOURNAL
LA English
DT Review
DE Mitochondria; Health; Mitochondrial stress; Mitochondrial health index;
   Bioenergetic health index; Mitochondrial fusion and fission; Cell
   apoptosis; Systemic effects; Ischemia-reperfusion; Ischemic stroke;
   Disease development; Disease severity; COVID-19; Predictive preventive
   personalized medicine (PPPM; 3PM); Primary secondary tertiary care;
   Health policy
ID DNA COPY NUMBER; RESPIRATORY CAPACITY; PERIPHERAL-BLOOD; WILD-TYPE;
   MTDNA; APOPTOSIS; INDEX; BIOENERGETICS; TRANSCRIPTION; ASSOCIATION
AB Mitochondria are the "gatekeeper" in a wide range of cellular functions, signaling events, cell homeostasis, proliferation, and apoptosis. Consequently, mitochondrial injury is linked to systemic effects compromising multi-organ functionality. Although mitochondrial stress is common for many pathomechanisms, individual outcomes differ significantly comprising a spectrum of associated pathologies and their severity grade. Consequently, a highly ambitious task in the paradigm shift from reactive to predictive, preventive, and personalized medicine (PPPM/3PM) is to distinguish between individual disease predisposition and progression under circumstances, resulting in compromised mitochondrial health followed by mitigating measures tailored to the individualized patient profile. For the successful implementation of PPPM concepts, robust parameters are essential to quantify mitochondrial health sustainability. The current article analyses added value of Mitochondrial Health Index (MHI) and Bioenergetic Health Index (BHI) as potential systems to quantify mitochondrial health relevant for the disease development and its severity grade. Based on the pathomechanisms related to the compromised mitochondrial health and in the context of primary, secondary, and tertiary care, a broad spectrum of conditions can significantly benefit from robust quantification systems using MHI/BHI as a prototype to be further improved. Following health conditions can benefit from that: planned pregnancies (improved outcomes for mother and offspring health), suboptimal health conditions with reversible health damage, suboptimal life-style patterns and metabolic syndrome(s) predisposition, multi-factorial stress conditions, genotoxic environment, ischemic stroke of unclear aetiology, phenotypic predisposition to aggressive cancer subtypes, pathologies associated with premature aging and neuro/degeneration, acute infectious diseases such as COVID-19 pandemics, among others.
C1 [Koklesova, Lenka; Mazurakova, Alena; Kudela, Erik; Biringer, Kamil] Comenius Univ, Jessenius Fac Med, Clin Obstet & Gynecol, Martin 03601, Slovakia.
   [Samec, Marek] Comenius Univ, Jessenius Fac Med, Dept Pathol Physiol, Martin 03601, Slovakia.
   [Kubatka, Peter] Comenius Univ, Jessenius Fac Med, Dept Med Biol, Martin 03601, Slovakia.
   [Golubnitschaja, Olga] Rheinische Friedrich Wilhelms Univ Bonn, Univ Hosp Bonn, Dept Radiat Oncol, Predict Prevent Personalised 3P Med, D-53127 Bonn, Germany.
C3 Comenius University Bratislava; Comenius University Bratislava; Comenius
   University Bratislava; University of Bonn
RP Golubnitschaja, O (corresponding author), Rheinische Friedrich Wilhelms Univ Bonn, Univ Hosp Bonn, Dept Radiat Oncol, Predict Prevent Personalised 3P Med, D-53127 Bonn, Germany.
EM olga.golubnitschaja@ukbonn.de
RI Biringer, Kamil/AAM-3696-2021; Kudela, Erik/X-9600-2018
OI Golubnitschaja, Prof. Dr., Olga/0000-0001-5427-2018; Lackova,
   Lenka/0009-0000-2732-066X; Kubatka, Peter/0000-0003-4312-5076
FU Projekt DEAL; European Association for Predictive, Preventive and
   Personalised Medicine; LISPER project [313011V446]
FX Open Access funding enabled and organized by Projekt DEAL. The present
   study was supported by the LISPER project (grant Nr. 313011V446) in
   bilateral agreement with the European Association for Predictive,
   Preventive and Personalised Medicine.
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NR 107
TC 48
Z9 51
U1 0
U2 9
PU SPRINGER INT PUBL AG
PI CHAM
PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND
SN 1878-5077
EI 1878-5085
J9 EPMA J
JI EPMA J.
PD JUN
PY 2022
VL 13
IS 2
SI SI
BP 177
EP 193
DI 10.1007/s13167-022-00281-6
EA MAY 2022
PG 17
WC Medicine, General & Internal; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Research & Experimental Medicine
GA 2E5EZ
UT WOS:000794090300001
PM 35578648
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Guarneri, F
   Sapienza, D
   Papaianni, V
   Marafioti, I
   Guarneri, C
   Mondello, C
   Roccuzzo, S
   Asmundo, A
   Cannavò, SP
AF Guarneri, F.
   Sapienza, D.
   Papaianni, V.
   Marafioti, I.
   Guarneri, C.
   Mondello, C.
   Roccuzzo, S.
   Asmundo, A.
   Cannavo, S. P.
TI Association between genetic polymorphisms of glutathione S-transferase
   M1/T1 and psoriasis in a population from the area of the strict of
   messina (Southern Italy)
SO FREE RADICAL RESEARCH
LA English
DT Article
DE Genetic polymorphisms; glutathione S-transferase; oxidative stress;
   predisposing factors; psoriasis
ID OXIDATIVE STRESS; METABOLIZING-ENZYMES; SOLAR KERATOSES; GSTT1; M1; T1;
   SUSCEPTIBILITY; GENOTYPE; GSTM1; EPIDEMIOLOGY
AB Glutathione S-transferases (GST) are antioxidant enzymes with frequent genetic polymorphisms. Homozygosis for gene deletion ("null" genotype) of GSTM1 and GSTT1, causing decrease of the antioxidant potential of the organism, is frequent, with variable frequency in different ethnic contexts. Although oxidative stress notoriously plays a role in the pathogenesis of psoriasis, few studies exist on the association between GSTM1/GSTT1 genotype and psoriasis, with different results. We aimed to assess the frequency of GSTM1/GSTT1 polymorphisms in Southern Italian psoriatic patients and controls and investigate the association of the GSTM1/GSTT1 genotype with individual and disease parameters. To this aim, the GSTM1/GSTT1 genotype of 148 psoriatic patients and 148 age- and sex-matched controls was defined by PCR on oral mucosa cells. GSTT1 null was associated with psoriasis (55.4% of patients vs. 25% of controls, p = 9.58 x 10(-8), odds ratio 3.73), while GSTM1 null was not. The GSTM1/GSTT1 "double null" genotype conferred an even higher odds ratio for psoriasis (5.94). The association between psoriasis and GSTT1 null was stronger in women (54.1% of patients vs. 19.7% of controls, p = 8.13 x 10(-5)) than in men (56.3% of patients vs. 28.7% of controls, p = 0.0002). No association was found between GSTM1/GSTT1 genotype and psoriasis severity, age of onset or comorbidities (psoriatic arthritis, metabolic syndrome). The remarkable differences among the few available data on the association between GSTM1/GSTT1 polymorphisms and psoriasis suggest the need for further studies, on different and larger populations, to improve knowledge on the pathogenesis of psoriasis and possibly provide more precise and personalised prevention and treatment in the future.
C1 [Guarneri, F.; Papaianni, V.; Marafioti, I.; Cannavo, S. P.] Univ Messina, Sect Dermatol, Dept Clin & Expt Med, Messina, Italy.
   [Sapienza, D.; Guarneri, C.; Mondello, C.; Roccuzzo, S.; Asmundo, A.] Univ Messina, Dept Biomed Sci Dent & Morphol & Funct Images, Messina, Italy.
C3 University of Messina; University of Messina
RP Guarneri, F (corresponding author), Viale Annunziata,Villa 7, Messina, Italy.
EM f.guarneri@tiscali.it
RI Sapienza, Daniela/AAX-1497-2021; Mondello, Cristina/AAI-2123-2020;
   Sapienza, Daniela/U-5696-2017
OI Cannavo, Serafinella/0000-0001-5459-3129; Roccuzzo,
   Salvatore/0000-0003-1902-4371; Guarneri, Fabrizio/0000-0003-0805-8496;
   Sapienza, Daniela/0000-0002-3595-7086
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NR 40
TC 12
Z9 12
U1 0
U2 5
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1071-5762
EI 1029-2470
J9 FREE RADICAL RES
JI Free Radic. Res.
PD JAN 1
PY 2020
VL 54
IS 1
BP 57
EP 63
DI 10.1080/10715762.2019.1698738
EA DEC 2019
PG 7
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 3L2PB
UT WOS:000502012600001
PM 31774007
DA 2025-06-11
ER

PT J
AU Huang, XQ
   Zhang, J
   Liu, J
   Sun, L
   Zhao, HY
   Lu, YG
   Wang, JC
   Li, J
AF Huang, Xiuqing
   Zhang, Jing
   Liu, Jin
   Sun, Liang
   Zhao, Hongye
   Lu, Yonggang
   Wang, Jianchang
   Li, Jian
TI C-reactive protein promotes adhesion of monocytes to endothelial cells
   via NADPH oxidase-mediated oxidative stress
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Article
DE C-REACTIVE PROTEIN; INTIMA-MEDIA THICKNESS; NADPH OXIDASE; MONOCYTES
ID METABOLIC SYNDROME; UP-REGULATION; ATHEROSCLEROSIS; INFLAMMATION;
   GLUCOSE; ATHEROTHROMBOSIS; LEUKOCYTES; INDUCTION; THICKNESS; DAMAGE
AB Enhanced monocyte adhesion to endothelial cells is an early event in atherogenesis. It has been shown that C-reactive protein (CRP) plays a key role in atherogenesis. Here, we investigated the effects of CRP on monocyte-endothelial cell adhesion and tested the hypothesis that NADPH oxidase (NOX)-mediated oxidative stress might play a key role in CRP-induced monocyte-endothelial cell adhesion. Firstly, 36 patients with carotid intima-media thickness (IMT) incrassation and 34 controls were enrolled in this study. The levels of glucose, lipids, CRP, monocyte chemotractant protein (MCP-1), malondialdehyde (MDA), and protein carbonylation were analyzed. The results showed that carotid IMT was associated with abnormal lipid metabolism, including elevated CRP, triglycerides (TG) (P<0.01) and decreased high density lipoprotein (HDL) level (P<0.05). The levels of CRP and MCP-1 in patients with carotid IMT incrassation were increased compared with the controls (P<0.01). Moreover, patients with carotid IMT incrassation displayed enhanced MDA and protein carbonylation levels (P<0.01), accompanied by activation and up-regulation of NOX in monocytes (P<0.05) compared with the controls. The monocytes isolated from five healthy donors were used for in vitro experiments. Reactive oxygen species (ROS) production and NOX expression in monocytes were examined. The results also indicated that CRP could promote the adhesion of monocyte-endothelial cell by up-regulation of MCP-1 expression (P<0.05). Importantly, NF? B and p38 MAPK signaling pathways, which were activated by NOX-derived ROS, were involved in CRP-induced monocyte-endothelial cell adhesion and up-regulation of MCP-1 expression. These data suggested that CRP could promote the adhesion of monocytes to endothelial cells via NOX-mediated oxidative stress. J. Cell. Biochem. 113: 857867, 2012. (C) 2011 Wiley Periodicals, Inc.
C1 [Zhang, Jing; Wang, Jianchang] Air Force Gen Hosp, Dept Gerontol, Beijing 100036, Peoples R China.
   [Huang, Xiuqing; Sun, Liang; Zhao, Hongye; Lu, Yonggang; Li, Jian] Beijing Hosp, Key Lab Geriatr, Beijing 100730, Peoples R China.
   [Huang, Xiuqing; Sun, Liang; Zhao, Hongye; Lu, Yonggang; Li, Jian] Beijing Inst Geriatr, Minist Hlth, Beijing 100730, Peoples R China.
   [Liu, Jin] Beijing Normal Univ, Coll Life Sci, Beijing 100875, Peoples R China.
C3 Air Force General Hospital PLA; Beijing Hospital; Beijing Normal
   University
RP Wang, JC (corresponding author), Air Force Gen Hosp, Dept Gerontol, Beijing 100036, Peoples R China.
EM kzdw66@sohv.com; lijian@bjhmoh.cn
FU National Basic Research Program of China [2006CB 503910]; National
   Natural Science foundation of China [30572082, 30801218, 30801208];
   Natural Science foundation of Beijing [7052059, 7092092]
FX Grant sponsor: National Basic Research Program of China; Grant number:
   2006CB 503910; Grant sponsor: National Natural Science foundation of
   China; Grant numbers: 30572082, 30801218, 30801208; Grant sponsor:
   Natural Science foundation of Beijing; Grant numbers: 7052059, 7092092.
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NR 35
TC 22
Z9 26
U1 1
U2 21
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0730-2312
EI 1097-4644
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PD MAR
PY 2012
VL 113
IS 3
BP 857
EP 867
DI 10.1002/jcb.23415
PG 11
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA 879ND
UT WOS:000299335700016
PM 22020763
DA 2025-06-11
ER

PT J
AU Rezazadeh, A
   Yazdanparast, R
   Molaei, M
AF Rezazadeh, Alireza
   Yazdanparast, Razieh
   Molaei, Mahsa
TI Amelioration of diet-induced nonalcoholic steatohepatitis in rats by
   Mn-salen complexes via reduction of oxidative stress
SO JOURNAL OF BIOMEDICAL SCIENCE
LA English
DT Article
DE Nonalcoholic fatty liver; superoxide dismutase mimetic; oxidative
   stress; Mn-salen complexes; methionine and choline deficient diet
ID SUPEROXIDE DISMUTASE/CATALASE MIMETICS; METABOLIC SYNDROME; ANTIOXIDANT;
   LIVER; PROGRESSION; MODEL; HDL
AB Background: Nonalcoholic steatohepatitis (NASH), a progressive stage of nonalcoholic fatty liver disease (NAFLD), is characterized by steatosis (accumulation of triacylglycerols within hepatocytes) along with inflammation and ballooning degeneration. It has been suggested that oxidative stress may play an important role in the progress of NAFLD to NASH. The aim of present study was to determine whether antioxidant supplementations using EUK-8, EUK-134 and vitamin C could improve the biochemical and histological abnormalities associated with diet-induced NASH in rats.
   Methods: NASH was induced in male N-Mary rats by feeding a methionine - choline deficient (MCD) diet. The rats were fed either normal chow or MCD diet for 10 weeks. After NASH development, the MCD-fed rats were randomly divided into four groups of six: the NASH group that received MCD diet, the EUK-8 group which was fed MCD diet plus EUK-8, the EUK-134 group which was fed MCD diet plus EUK-134 and the vitamin C group which received MCD diet plus vitamin C. EUK-8, EUK-134 and vitamin C (30 mg/kg body weight/day) were administered by gavage for eight weeks.
   Results: Treatment of MCD-fed rats with salens reduced the sera aminotransferases, cholesterol, low density lipoprotein contents, the extent of lipid peroxidation and protein carbonylation whereas the HDL-C cholesterol levels were significantly increased. In addition, EUK-8 and EUK-134 improved steatosis, ballooning degeneration and inflammation in liver of MCD-fed rats.
   Conclusion: Antioxidant (EUK-8, EUK-134 and vitamin C) supplementation reduces NASH-induced biochemical and histological abnormalities, pointing out that antioxidant strategy could be beneficial in treatment of NASH.
C1 [Rezazadeh, Alireza; Yazdanparast, Razieh] Univ Tehran, Inst Biochem & Biophys, Tehran, Iran.
   [Molaei, Mahsa] Shahid Beheshti Univ Med Sci, Res Ctr Gastroenterol & Liver Dis, Tehran, Iran.
C3 University of Tehran; Shahid Beheshti University Medical Sciences
RP Yazdanparast, R (corresponding author), Univ Tehran, Inst Biochem & Biophys, Tehran, Iran.
EM yazdan@ibb.ut.ac.ir
RI Yazdanpanah, M./E-9608-2018; Rezazadeh, Alireza/G-5632-2010
OI Rezazadeh, Alireza/0000-0002-6104-1717; dehghani,
   Mohsen/0000-0002-2321-6555
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NR 34
TC 39
Z9 42
U1 0
U2 13
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1021-7770
EI 1423-0127
J9 J BIOMED SCI
JI J. Biomed. Sci.
PD FEB 29
PY 2012
VL 19
AR 26
DI 10.1186/1423-0127-19-26
PG 8
WC Cell Biology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Research & Experimental Medicine
GA 916JS
UT WOS:000302099100001
PM 22375551
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Yang, XY
   Liu, YC
   Cao, JH
   Wu, CY
   Tang, LS
   Bian, WX
   Chen, YH
   Yu, LY
   Wu, YY
   Li, SN
   Shen, YH
   Xia, J
   Du, J
AF Yang, Xinyi
   Liu, Yingchao
   Cao, Jinghao
   Wu, Cuiyun
   Tang, Lusheng
   Bian, Wenxia
   Chen, Yuhan
   Yu, Lingyan
   Wu, Yunyi
   Li, Sainan
   Shen, Yuhuan
   Xia, Jun
   Du, Jing
TI Targeting epigenetic and post-translational modifications of NRF2: key
   regulatory factors in disease treatment
SO CELL DEATH DISCOVERY
LA English
DT Review
ID PROTEIN-KINASE-C; ANTIOXIDANT RESPONSE; OXIDATIVE STRESS; TRANSCRIPTION
   FACTOR; ENDOTHELIAL-CELLS; SIGNALING PATHWAY; LUNG-CANCER;
   PHOSPHORYLATION; INJURY; KEAP1
AB Nuclear factor erythroid 2-related factor 2 (NRF2) is a key transcription factor involved in regulating cellular antioxidant defense and detoxification mechanisms. It mitigates oxidative stress and xenobiotic-induced damage by inducing the expression of cytoprotective enzymes, including HO-1 and NQO1. NRF2 also modulates inflammatory responses by inhibiting pro-inflammatory genes and mediates cell death pathways, including apoptosis and ferroptosis. Targeting NRF2 offers potential therapeutic avenues for treating various diseases. NRF2 is regulated through two principal mechanisms: post-translational modifications (PTMs) and epigenetic alterations. PTMs, including phosphorylation, ubiquitination, and acetylation, play a pivotal role in modulating NRF2's stability, activity, and subcellular localization, thereby precisely controlling its function in the antioxidant response. For instance, ubiquitination can lead to NRF2 degradation and reduced antioxidant activity, while deubiquitination enhances its stability and function. Epigenetic modifications, such as DNA methylation, histone modifications, and interactions with non-coding RNAs (e.g., MALAT1, PVT1, MIR4435-2HG, and TUG1), are essential for regulating NRF2 expression by modulating chromatin architecture and gene accessibility. This paper systematically summarizes the molecular mechanisms by which PTMs and epigenetic alterations regulate NRF2, and elucidates its critical role in cellular defense and disease. By analyzing the impact of PTMs, such as phosphorylation, ubiquitination, and acetylation, as well as DNA methylation, histone modifications, and non-coding RNA interactions on NRF2 stability, activity, and expression, the study reveals the complex cellular protection network mediated by NRF2. Furthermore, the paper explores how these regulatory mechanisms affect NRF2's roles in oxidative stress, inflammation, and cell death, identifying novel therapeutic targets and strategies. This provides new insights into the treatment of NRF2-related diseases, such as cancer, neurodegenerative disorders, and metabolic syndrome. This research deepens our understanding of NRF2's role in cellular homeostasis and lays the foundation for the development of NRF2-targeted therapies.
C1 [Yang, Xinyi; Liu, Yingchao; Cao, Jinghao; Tang, Lusheng; Bian, Wenxia; Chen, Yuhan; Yu, Lingyan; Wu, Yunyi; Li, Sainan; Shen, Yuhuan; Xia, Jun; Du, Jing] Hangzhou Med Coll, Dept Clin Lab, Lab Med Ctr, Zhejiang Prov Peoples Hosp,Affiliated Peoples Hosp, Hangzhou, Zhejiang, Peoples R China.
   [Wu, Cuiyun] Hangzhou Med Coll, Zhejiang Prov Peoples Hosp, Affiliated Peoples Hosp, Dept Radiol ,Canc Ctr, Hangzhou, Zhejiang, Peoples R China.
C3 Hangzhou Medical College; Zhejiang Provincial People's Hospital;
   Hangzhou Medical College; Zhejiang Provincial People's Hospital
RP Shen, YH; Xia, J; Du, J (corresponding author), Hangzhou Med Coll, Dept Clin Lab, Lab Med Ctr, Zhejiang Prov Peoples Hosp,Affiliated Peoples Hosp, Hangzhou, Zhejiang, Peoples R China.
EM shen_yh@zju.edu.cn; xiajun@hmc.edu.cn; dujing1@hmc.edu.cn
RI Cao, Jinghao/JBS-5560-2023
FU National Natural Science Foundation of China [82102938]; Medical and
   Health Science and Technology Project of Zhejiang Province [2022KY551];
   Basic Scientific Research Funds of Department of Education of Zhejiang
   Province [KYYB2023012]; Zhejiang Province Traditional Chinese Medicine
   Science and Technology Project [2022ZB018]
FX This research was supported by the National Natural Science Foundation
   of China (No. 82102938). Medical and Health Science and Technology
   Project of Zhejiang Province (Grant No. 2022KY551). Basic Scientific
   Research Funds of Department of Education of Zhejiang Province (No.
   KYYB2023012). Zhejiang Province Traditional Chinese Medicine Science and
   Technology Project (No. 2022ZB018).
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NR 173
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U2 0
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
EI 2058-7716
J9 CELL DEATH DISCOV
JI Cell Death Discov.
PD APR 21
PY 2025
VL 11
IS 1
AR 189
DI 10.1038/s41420-025-02491-z
PG 16
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA 1RI4R
UT WOS:001471816300001
PM 40258841
DA 2025-06-11
ER

PT J
AU Labandeira-Garcia, JL
   Labandeira, CM
   Guerra, MJ
   Rodriguez-Perez, AI
AF Labandeira-Garcia, Jose Luis
   Labandeira, Carmen M.
   Guerra, Maria J.
   Rodriguez-Perez, Ana I.
TI The role of the brain renin-angiotensin system in Parkinson<acute
   accent>s disease
SO TRANSLATIONAL NEURODEGENERATION
LA English
DT Review
DE Angiotensin; Dopamine; NADPH-oxidase; Neurodegeneration;
   Neuroprotection; Neuroinflammation; Oxidative stress; Parkinson
ID NIGROSTRIATAL DOPAMINE NEURONS; II TYPE-1 RECEPTOR; CONVERTING-ENZYME;
   NADPH-OXIDASE; METABOLIC SYNDROME; OXIDATIVE STRESS; GENE-EXPRESSION;
   ADIPOSE-TISSUE; MITOCHONDRIAL DYSFUNCTION; MICROGLIAL ACTIVATION
AB The renin-angiotensin system (RAS) was classically considered a circulating hormonal system that regulates blood pressure. However, different tissues and organs, including the brain, have a local paracrine RAS. Mutual regulation between the dopaminergic system and RAS has been observed in several tissues. Dysregulation of these interactions leads to renal and cardiovascular diseases, as well as progression of dopaminergic neuron degeneration in a major brain center of dopamine/angiotensin interaction such as the nigrostriatal system. A decrease in the dopaminergic function induces upregulation of the angiotensin type-1 (AT1) receptor activity, leading to recovery of dopamine levels. However, AT1 receptor overactivity in dopaminergic neurons and microglial cells upregulates the cellular NADPH-oxidase-superoxide axis and Ca2+ release, which mediate several key events in oxidative stress, neuroinflammation, and alpha-synuclein aggregation, involved in Parkinson's disease (PD) pathogenesis. An intraneuronal antioxidative/anti-inflammatory RAS counteracts the effects of the pro-oxidative AT1 receptor overactivity. Consistent with this, an imbalance in RAS activity towards the pro-oxidative/pro-inflammatory AT1 receptor axis has been observed in the substantia nigra and striatum of several animal models of high vulnerability to dopaminergic degeneration. Interestingly, autoantibodies against angiotensin-converting enzyme 2 and AT1 receptors are increased in PD models and PD patients and contribute to blood-brain barrier (BBB) dysregulation and nigrostriatal pro-inflammatory RAS upregulation. Therapeutic strategies addressed to the modulation of brain RAS, by AT1 receptor blockers (ARBs) and/or activation of the antioxidative axis (AT2, Mas receptors), may be neuroprotective for individuals with a high risk of developing PD or in prodromal stages of PD to reduce progression of the disease.
C1 [Labandeira-Garcia, Jose Luis; Guerra, Maria J.; Rodriguez-Perez, Ana I.] Univ Santiago de Compostela, Res Ctr Mol Med & Chron Dis CIMUS, Cellular & Mol Neurobiol Parkinsons Dis, IDIS, Santiago De Compostela 15782, Spain.
   [Labandeira-Garcia, Jose Luis; Guerra, Maria J.; Rodriguez-Perez, Ana I.] Networking Res Ctr Neurodegenerat Dis CIBERNED, Madrid, Spain.
   [Labandeira, Carmen M.] Univ Hosp Ourense, Neurol Serv, Orense, Spain.
C3 Universidade de Santiago de Compostela; CIBERNED; Complexo Hospitalario
   Universitario de Ourense, Verin e O Barco de Valdeorras
RP Labandeira-Garcia, JL; Rodriguez-Perez, AI (corresponding author), Univ Santiago de Compostela, Res Ctr Mol Med & Chron Dis CIMUS, Cellular & Mol Neurobiol Parkinsons Dis, IDIS, Santiago De Compostela 15782, Spain.; Labandeira-Garcia, JL; Rodriguez-Perez, AI (corresponding author), Networking Res Ctr Neurodegenerat Dis CIBERNED, Madrid, Spain.
EM joseluis.labandeira@usc.es; anai.rodriguez@usc.es
RI Perez, Ana/AAM-1198-2021; García, José/AAM-3097-2021
OI Labandeira Guerra, Carmen M./0000-0002-6274-5871
FU Ministerio de Ciencia e Innovacin
FX Not applicable.
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NR 239
TC 10
Z9 12
U1 1
U2 4
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 2047-9158
J9 TRANSL NEURODEGENER
JI Transl. Neurodegener.
PD APR 15
PY 2024
VL 13
IS 1
AR 22
DI 10.1186/s40035-024-00410-3
PG 19
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA OB2K3
UT WOS:001204733000001
PM 38622720
OA gold
DA 2025-06-11
ER

PT J
AU Feng, Y
   Lin, J
   Su, M
   Zhang, X
   Fang, DZ
AF Feng, Yue
   Lin, Jia
   Su, Mi
   Zhang, Xin
   Fang, Ding Zhi
TI Interplays of estrogen receptor alpha gene rs2234693 with post-traumatic
   stress disorder influence serum glucose and lipids profiles in Chinese
   adolescents
SO JOURNAL OF CLINICAL NEUROSCIENCE
LA English
DT Article
DE Estrogen receptor alpha gene; Polymorphism; Post-traumatic stress
   disorder; Interaction; Blood glucose; Lipids profiles
ID DENSITY-LIPOPROTEIN CHOLESTEROL; CORONARY-ARTERY-DISEASE; RISK-FACTORS;
   PSYCHOMETRIC PROPERTIES; WENCHUAN EARTHQUAKE; INSULIN-RESISTANCE;
   METABOLIC SYNDROME; DIABETES-MELLITUS; PTSD CHECKLIST; POLYMORPHISMS
AB Both post-traumatic stress disorder (PTSD) and estrogen receptor alpha (ESR1) gene rs2234693 were reported to influence serum glucose and lipids profiles. However, their interactions on serum glucose and lipids profiles have not been reported. A total of 708 Chinese Han high school students were recruited at 6th months after the 2008 Wenchuan Earthquake. Serum concentrations of fasting blood glucose (FBG), fasting blood insulin (FBI), total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) were detected. Body mass index (BMI) and homeostatic model assessment of insulin resistance (HOMA-IR) were calculated. PTSD was assessed by the PTSD Checklist Civilian Version (PCL-C). Variants of ESR1 rs2234693 was analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analyses and verified by DNA sequencing. The male subjects with PTSD had a trend of higher FBG (p = 0.077) and significantly higher FBI and HOMA-IR than male controls. The PTSD subjects had significantly higher levels of FBG, FBI. HOMA-IR and HDL-C than the controls only in the male C allele carriers irrespective of adjustment for age and BMI. In the male controls group, the C allele carriers had significantly lower HDL-C than the TT homozygotes regardless of adjustment for age and BMI. In female PTSD group, the C allele carriers had significantly higher TC/HDL-C and LDL-C/HDL-C than the TT homozygotes after adjustment for age and BMI. These results suggest the interplays of ESR1 rs2234693 with PTSD influence serum glucose and lipids profiles with a gender dependent manner. (C) 2018 Elsevier Ltd. All rights reserved.
C1 [Feng, Yue; Lin, Jia; Su, Mi; Zhang, Xin; Fang, Ding Zhi] Sichuan Univ, West China Sch Basic Med Sci & Forens Med, Dept Biochem & Mol Biol, 17 Sect 3,South Renmin Rd, Chengdu 610041, Sichuan, Peoples R China.
   [Feng, Yue] Mianyang Cent Hosp, Dept Clin Lab, Mianyang, Peoples R China.
C3 Sichuan University
RP Fang, DZ (corresponding author), Sichuan Univ, West China Sch Basic Med Sci & Forens Med, Dept Biochem & Mol Biol, 17 Sect 3,South Renmin Rd, Chengdu 610041, Sichuan, Peoples R China.
EM dzfang@scu.edu.cn
RI Feng, Yue/KRV-7921-2024
FU Chengdu Program for Sciences and Technology [2015-HM01-00404-SF]
FX This study was supported by the Chengdu Program for Sciences and
   Technology (Grant no. 2015-HM01-00404-SF). Dr. Ding Zhi Fang is the
   recipient of the grants.
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NR 56
TC 2
Z9 2
U1 0
U2 12
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0967-5868
EI 1532-2653
J9 J CLIN NEUROSCI
JI J. Clin. Neurosci.
PD MAR
PY 2019
VL 61
BP 36
EP 43
DI 10.1016/j.jocn.2018.11.021
PG 8
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA HO3SY
UT WOS:000460844400007
PM 30470649
DA 2025-06-11
ER

PT J
AU Wu, KLH
   Wu, CW
   Tain, YL
   Chao, YM
   Hung, CY
   Tsai, PC
   Wang, WS
   Shih, CD
AF Wu, Kay L. H.
   Wu, Chih-Wei
   Tain, You-Lin
   Chao, Yung-Mei
   Hung, Chun-Ying
   Tsai, Pei-Chia
   Wang, Wei-Sing
   Shih, Cheng-Dean
TI Effects of high fructose intake on the development of hypertension in
   the spontaneously hypertensive rats: the role of AT1R/gp91
   <SUP>PHOX</SUP> signaling in the rostral ventrolateral medulla
SO JOURNAL OF NUTRITIONAL BIOCHEMISTRY
LA English
DT Article
DE High-fructose diet; Spontaneously hypertensive rat; Rostral
   ventrolateral medulla; Oxidative stress; Hypertension
ID ANGIOTENSIN-II TYPE-1; SYMPATHETIC-NERVOUS-SYSTEM; ELEVATED
   BLOOD-PRESSURE; NITRIC-OXIDE SYNTHASE; OXIDATIVE STRESS; METABOLIC
   SYNDROME; DIABETES-MELLITUS; LIPID-METABOLISM; NEUROGENIC HYPERTENSION;
   CIRCULATING MONOCYTES
AB Both genetic and dietary factors determine the development of hypertension. Whether dietary factor impacts the development of hereditary hypertension is unknown. Here, we evaluated the effect of daily high-fructose diet (HFD) on the development of hypertension in adolescent spontaneously hypertensive rats (SHR). Six week -old SHR were randomly divided into two groups to receive HFD or normal diet (ND) for 3 weeks. The temporal profile of systolic blood pressure, alongside the sympathetic vasomotor activity, in the SHR-HFD showed significantly greater increases at 9-12 weeks of age compared with the age-matched SHR-ND group. Immunofluorescence was used to identify the distribution of reactive oxygen species (ROS), oxidants and antioxidants in rostra] ventrolateral medulla (RVLM) where sympathetic premotor neurons reside. In RVLM of SHR-HFD, the levels of ROS accumulation and lipid peroxidation were elevated. The changes in protein expression were measured by Western blot. NADPH oxidase subunit gp91(Phox) and angiotensin II type I receptor were up-regulated in RVLM neuron. On the other hand, the expression of extracellular superoxide dismutase was suppressed. Both molecular and hemodynamic changes in the SHR-HFD were rescued by oral pioglitazone treatment from weeks 7 to 9. Furthermore, central infusion with tempol, a ROS scavenger, effectively ameliorated ROS accumulation in RVLM and diminished the heightened pressor response and enhanced sympathetic activity in the SHR-HFD. Together, these results suggest that HFD intake at adolescent SHR may impact the development of hypertension via increasing oxidative stress in RVLM which could be effectively attenuated by pioglitazone treatment. (C) 2016 Elsevier Inc. All rights reserved.
C1 [Wu, Kay L. H.; Wu, Chih-Wei; Tain, You-Lin; Chao, Yung-Mei; Hung, Chun-Ying; Tsai, Pei-Chia; Wang, Wei-Sing] Kaohsiung Chang Gung Mem Hosp, Inst Translat Res Biomed, Kaohsiung 83301, Taiwan.
   [Wu, Kay L. H.] Natl Tainan Inst Nursing, Dept Senior Citizen Serv, Tainan 700, Taiwan.
   [Tain, You-Lin] Chang Gung Univ, Chang Gung Mem Hosp, Coll Med, Dept Pediat, Kaohsiung 833, Taiwan.
   [Shih, Cheng-Dean] Tajen Univ, Grad Inst Pharmaceut Technol, Dept Pharm, Pingtung 90741, Taiwan.
C3 Chang Gung Memorial Hospital; Chang Gung University; Chang Gung Memorial
   Hospital
RP Wu, KLH (corresponding author), Kaohsiung Chang Gung Mem Hosp, Inst Translat Res Biomed, Kaohsiung 83301, Taiwan.; Shih, CD (corresponding author), Tajen Univ, Grad Inst Pharmaceut Technol, Dept Pharm, Pingtung 90741, Taiwan.
EM klhwu@adm.cgmh.org.tw; cdshih@mail.tajen.edu.tw;
   cdshih@mail.tajen.edu.tw
RI Wu, Kay/ACD-1767-2022; Tain, You-Lin/H-2827-2019
OI Tain, You-Lin/0000-0002-7059-6407; Wu, Kay L.H./0000-0002-7297-6788
FU Chang Gung Memorial Hospital Taiwan, Republic of China [CMRPG8E0831,
   CMRPG8D0101, CMRPG8C6011, CMRPG8C6012]; Ministry of Science and
   Technology, Taiwan, Republic of China [MOST 103-2320-B-182A-010]
FX This study was supported in part by Chang Gung Memorial Hospital Taiwan,
   Republic of China (grant numbers CMRPG8E0831, CMRPG8D0101, CMRPG8C6011,
   CMRPG8C6012) and the Ministry of Science and Technology, Taiwan,
   Republic of China (MOST 103-2320-B-182A-010) to K.L.H.W.
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NR 76
TC 15
Z9 15
U1 0
U2 5
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0955-2863
EI 1873-4847
J9 J NUTR BIOCHEM
JI J. Nutr. Biochem.
PD MAR
PY 2017
VL 41
BP 73
EP 83
DI 10.1016/j.jnutbio.2016.11.013
PG 11
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA EL9EO
UT WOS:000394922700009
PM 28063367
DA 2025-06-11
ER

PT J
AU Musthafa, QA
   Shukor, MFA
   Ismail, NAS
   Ghazi, AM
   Ali, RM
   Nor, IFM
   Dimon, MZ
   Ngah, WZW
AF Musthafa, Qurratu Aini
   Shukor, Muhd Faizan Abdul
   Ismail, Noor Akmal Shareela
   Ghazi, Azmee Mohd
   Ali, Rosli Mohd
   Nor, Ika Faizura M.
   Dimon, Mohd Zamrin
   Ngah, Wan Zurinah Wan
TI Oxidative status and reduced glutathione levels in premature coronary
   artery disease and coronary artery disease
SO FREE RADICAL RESEARCH
LA English
DT Article
DE Premature coronary artery disease; atherosclerosis; oxidative stress;
   biomarkers; antioxidant
ID SMOOTH-MUSCLE-CELLS; DNA-DAMAGE; LIPID-PEROXIDATION; METABOLIC SYNDROME;
   ENDOTHELIAL DYSFUNCTION; MYOCARDIAL-INFARCTION; SUPEROXIDE-DISMUTASE;
   ANTIOXIDANT STATUS; RISK-FACTORS; VITAMIN-E
AB Identifying patients at risk of developing premature coronary artery disease (PCAD) which occurs at age below 45 years old and constitutes approximately 7-10% of coronary artery disease (CAD) worldwide remains a problem. Oxidative stress has been proposed as a crucial step in the early development of PCAD. This study was conducted to determine the oxidative status of PCAD in comparison to CAD patients. PCAD (<45 years old) and CAD (>60 years old) patients were recruited with age-matched controls (n = 30, each group). DNA damage score, plasma malondialdehyde (MDA) and protein carbonyl content were measured for oxidative damage markers. Antioxidants such as erythrocyte glutathione (GSH), oxidised glutathione (GSSG), and glutathione peroxidase activity (GPx), superoxide dismutase (SOD) and catalase (CAT) were also determined. DNA damage score and protein carbonyl content were significantly higher in both PCAD and CAD when compared to age-matched controls while MDA level was increased only in PCAD (p<.05). In contrast, GSH, GSH/GSSG ratio, alpha-tocotrienol isomer, and GPx activity were significantly decreased, but only in PCAD when compared to age-matched controls. The decrease in GSH was associated with PCAD (OR = 0.569 95%CI [0.375-0.864], p = .008) and cut-off values of 6.69 mu M with areas under the ROC curves (AUROC) 95%CI: 0.88 [0.80-0.96] (sensitivity of 83.3%; specificity of 80%). However, there were no significant differences in SOD and CAT activities in all groups. A higher level of oxidative stress indicated by elevated MDA levels and low levels of GSH, alpha-tocotrienol and GPx activity in patients below 45 years old may play a role in the development of PCAD and has potential as biomarkers for PCAD.
C1 [Musthafa, Qurratu Aini; Shukor, Muhd Faizan Abdul; Ismail, Noor Akmal Shareela; Ngah, Wan Zurinah Wan] Univ Kebangsaan Malaysia, Med Ctr, Fac Med, Dept Biochem, Cheras, Malaysia.
   [Ghazi, Azmee Mohd; Ali, Rosli Mohd; Nor, Ika Faizura M.] Natl Heart Inst Malaysia, Kuala Lumpur, Malaysia.
   [Dimon, Mohd Zamrin] UiTM Private Specialist Ctr, Dept Med, Selangor, Malaysia.
C3 Universiti Kebangsaan Malaysia
RP Ngah, WZW (corresponding author), Univ Kebangsaan Malaysia, Fac Med, Dept Biochem, UKM Med Ctr, Jalan Yaacob Latiff, Kuala Lumpur, Malaysia.
EM wanzurinah@ppukm.ukm.edu.my
RI Faizan, Shukor/AAF-9998-2021; Ismail, Noor/AAX-6904-2020
OI A. Shukor, Muhammad Faizan/0000-0002-3524-8538
FU UKM [ETP-2013-007/LRGS/BU/2012/UKM-UKM/K/04/DIP-2015-004]
FX This study was partly funded by several grants from UKM
   (ETP-2013-007/LRGS/BU/2012/UKM-UKM/K/04/DIP-2015-004). We would like to
   express our gratitude to National Heart Institute, Malaysia for samples
   recruitment and personnel from Department of Biochemistry, Universiti
   Kebangsaan Malaysia for their assistance. First author thanks UKM for
   the postgraduate studentship.
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NR 85
TC 27
Z9 27
U1 0
U2 5
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1071-5762
EI 1029-2470
J9 FREE RADICAL RES
JI Free Radic. Res.
PY 2017
VL 51
IS 9-10
BP 787
EP 798
DI 10.1080/10715762.2017.1379602
PG 12
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA FN0IB
UT WOS:000415660400004
PM 28899235
DA 2025-06-11
ER

PT J
AU Ma, WW
   Yuan, LH
   Yu, HL
   Xi, YD
   Xiao, R
AF Ma, Weiwei
   Yuan, Linhong
   Yu, Huanling
   Xi, Yuandi
   Xiao, Rong
TI Mitochondrial dysfunction and oxidative damage in the brain of
   diet-induced obese rats but not in diet-resistant rats
SO LIFE SCIENCES
LA English
DT Article
DE High-fat diet; Diet-induced obese rat; Diet-resistant rats; Oxidative
   damage; Mitochondrial dysfunction
ID HIGH-ENERGY DIET; METABOLIC SYNDROME; BARRIER INTEGRITY; STRESS; LEPTIN;
   RISK; GHRELIN; DEMENTIA; DISEASES; MIDLIFE
AB Aims: It has been suggested that obesity triggered by consuming a high-fat diet (HF) can account for oxidative damage and mitochondrial dysfunction. Thus, we aim to explore the oxidative stress and mitochondrial dysfunction detected in the brain of diet-induced obese (DIO) rats.
   Main methods: Sprague-Dawley (SD) rats were fed either a HF diet or a normal-fat (NF) diet for 10 weeks to obtain the control (CON), DIO and diet-resistant (DR) rats. D-Galactose was injected subcutaneously for 10 weeks to establish oxidative stress model (MOD) rats. Then, the levels of total antioxidant capacity (T-AOC), lipid peroxidation (LPO), malondialdehyde (MDA), both in plasma and brain tissue, and catalase (CAT) in plasma were measured using enzymic assay kits and the levels of ghrelin, neuropeptide Y (NPY) and leptin in both plasma and brain tissue were measured by using enzyme-linked immunosorbent assay (ELISA) kits. Mitochondrial reactive oxygen species (ROS) formation in brain tissues was detected with 2, 7-dichlorofluorescein diacetate (DCFH2-DA) dyeing. The mitochondrial membrane potential (MMP) was measured with tetrachloro-tetraethyl benzimidazol carbocyanine iodide (JC-1) by a flow cytometer.
   Key findings: HF diet leads to an obese or DR state characterized by increased or decreased adiposity. The HF diet increased brain LPO, which was accompanied by lower ghrelin levels in DIO rats compared with DR rats. In addition, the increased mitochondrial ROS and lower MMP were detected in DIO rat comparing with DR rats.
   Significance: The current results demonstrated that mitochondrial dysfunction and oxidative damage in the brains of DIO rats, induced by HF diets, might be measurable. (C) 2014 Elsevier Inc. All rights reserved.
C1 [Ma, Weiwei; Yuan, Linhong; Yu, Huanling; Xi, Yuandi; Xiao, Rong] Capital Med Univ, Beijing Key Lab Environm Toxicol, Sch Publ Hlth, Beijing 100069, Peoples R China.
C3 Capital Medical University
RP Xiao, R (corresponding author), 10 Xitoutiao, Beijing 100069, Peoples R China.
EM xiaor22@ccmu.edu.cn
RI yu, huan/ITT-7452-2023
FU National Natural Science Foundation of China [81102122]
FX This work was supported by the grants from National Natural Science
   Foundation of China (No. 81102122). Ma Weiwei and Yuan Linhong
   contributed to the implementation of the experiment and data analysis;
   Xi Yuandi and Yu Huanling performed the animal experiment and data
   analysis; and Xiao Rong designed the study.
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NR 38
TC 41
Z9 48
U1 0
U2 28
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0024-3205
EI 1879-0631
J9 LIFE SCI
JI Life Sci.
PD AUG 21
PY 2014
VL 110
IS 2
BP 53
EP 60
DI 10.1016/j.lfs.2014.07.018
PG 8
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA AM9TU
UT WOS:000340224700001
PM 25058918
DA 2025-06-11
ER

PT J
AU Uribarri, J
   Cai, WJ
   Pyzik, R
   Goodman, S
   Chen, X
   Zhu, L
   Ramdas, M
   Striker, GE
   Vlassara, H
AF Uribarri, Jaime
   Cai, Weijing
   Pyzik, Renata
   Goodman, Susan
   Chen, Xue
   Zhu, Li
   Ramdas, Maya
   Striker, Gary E.
   Vlassara, Helen
TI Suppression of native defense mechanisms, SIRT1 and PPARγ, by dietary
   glycoxidants precedes disease in adult humans; relevance to
   lifestyle-engendered chronic diseases
SO AMINO ACIDS
LA English
DT Article; Proceedings Paper
CT 11th International Symposium on the Maillard Reaction
CY SEP 16-20, 2012
CL Nancy, FRANCE
SP Int Maillard React Soc
DE Nutrition; Oxidative stress; Insulin resistance; Host defense
   mechanisms; Glycation
ID GLYCATION END-PRODUCTS; RENAL-FAILURE PATIENTS; INSULIN-RESISTANCE;
   DIABETIC-NEPHROPATHY; METABOLIC SYNDROME; OXIDATIVE STRESS; RISK-FACTOR;
   GLYCOTOXINS; INFLAMMATION; RESTRICTION
AB SIRT1 and PPAR gamma, host defenses regulating inflammation and metabolic functions, are suppressed under chronic high oxidant stress and inflammation (OS/Infl) conditions. In diabetes, dietary advanced glycation end products (dAGEs) cause OS/Infl and suppress SIRT1. Herein, we ask whether dAGEs also suppress host defense in adults without diabetes. The relationships between dAGEs and basal SIRT1 mRNA, PPAR gamma protein levels in mononuclear cells (MNC) and circulating inflammatory/metabolic markers were examined in 67 healthy adults aged > 60 years and in 18 subjects, before and after random assignment to either a standard diet (regular > 15 AGE Eq/day) or an isocaloric AGE-restricted diet (< 10 AGE Eq/day) for 4 months. Also, the interactions of AGEs and anti-AGE receptor-1 (AGER1) with SIRT1 and PPAR gamma were assessed in wild type (WT) and AGER1-transduced (AGER1(+)) MNC-like THP-1 cells. We found that dAGE, but not caloric intake, correlated negatively with MNC SIRT1 mRNA levels and positively with circulating AGEs (sAGEs), OS/infl, MNC TNF alpha and RAGE. Basal MNC PPAR gamma protein was also lower in consumers of regular vs. AGE-restricted diet. AGE restriction restored MNC SIRT1 and PPAR gamma, and significantly decreased sAGEs, 8-isoprostanes, VCAM-1, MNC TNF alpha and RAGE. Model AGEs suppressed SIRT1 protein and activity, and PPAR gamma protein in WT, but not in AGER1(+) cells in vitro. In conclusion, chronic consumption of high-AGE diets depletes defenses such as SIRT1 and PPAR gamma, independent of calories, predisposing to OS/Infl and chronic metabolic disease. Restricted entry of oral AGEs may offer a disease-prevention alternative for healthy adults.
C1 [Uribarri, Jaime; Cai, Weijing; Pyzik, Renata; Goodman, Susan; Chen, Xue; Zhu, Li; Ramdas, Maya; Striker, Gary E.; Vlassara, Helen] Mt Sinai Sch Med, Dept Geriatr, New York, NY 10029 USA.
C3 Icahn School of Medicine at Mount Sinai
RP Uribarri, J (corresponding author), Mt Sinai Sch Med, Dept Geriatr, One Gustave Levy Pl, New York, NY 10029 USA.
EM jaime.uribarri@mssm.edu; Helen.vlassara@mssm.edu
RI Uribarri, Jaime/ADX-7655-2022
OI uribarri, jaime/0000-0001-9826-1134
FU NCRR NIH HHS [M01-RR-00071, M01 RR000071] Funding Source: Medline; NIA
   NIH HHS [R37 AG023188, R01 AG009453, AG-23188, AG-09453] Funding Source:
   Medline; NIDDK NIH HHS [R01 DK091231] Funding Source: Medline
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NR 29
TC 60
Z9 63
U1 0
U2 20
PU SPRINGER WIEN
PI WIEN
PA SACHSENPLATZ 4-6, PO BOX 89, A-1201 WIEN, AUSTRIA
SN 0939-4451
EI 1438-2199
J9 AMINO ACIDS
JI Amino Acids
PD FEB
PY 2014
VL 46
IS 2
BP 301
EP 309
DI 10.1007/s00726-013-1502-4
PG 9
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Biochemistry & Molecular Biology
GA AA2XK
UT WOS:000330957300006
PM 23636469
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Haring, R
   Baumeister, SE
   Völzke, H
   Dörr, M
   Kocher, T
   Nauck, M
   Wallaschofski, H
AF Haring, Robin
   Baumeister, Sebastian E.
   Voelzke, Henry
   Doerr, Marcus
   Kocher, Thomas
   Nauck, Matthias
   Wallaschofski, Henri
TI Prospective Inverse Associations of Sex Hormone Concentrations in Men
   With Biomarkers of Inflammation and Oxidative Stress
SO JOURNAL OF ANDROLOGY
LA English
DT Article
DE Testosterone; fibrinogen; sex hormones
ID C-REACTIVE PROTEIN; GAMMA-GLUTAMYL-TRANSFERASE; CORONARY-HEART-DISEASE;
   LOW SERUM TESTOSTERONE; METABOLIC SYNDROME; CARDIOVASCULAR-DISEASE;
   REPLACEMENT THERAPY; MORTALITY RISK; OLDER MEN; FIBRINOGEN
AB The suggested associations between sex hormone concentrations and inflammatory biomarkers in men originate from cross-sectional studies and small-scale clinical trials. But prior studies have not investigated longitudinal associations. Overall, 1344 men aged 20-79 years from the population-based cohort Study of Health in Pomerania were followed up for 5.0 (median) years. We used multivariable regression models to analyze cross-sectional and longitudinal associations of serum sex hormone concentrations (total testosterone [TT], sex hormone binding globulin [SHBG], calculated free testosterone [free T], and dehydroepiandrosterone sulfate [DHEAS]) with biomarkers of inflammation (fibrinogen, high-sensitive C-reactive protein [hsCRP], and white blood cell count [WBC]) and oxidative stress (gamma-glutamyl transferase [GGT]) using ordinary least square regression and generalized estimating equation models, respectively. Cross-sectional models revealed borderline associations of sex hormone concentrations with hsCRP, WBC, and GGT levels that were not retained after multivariable adjustment. Longitudinal multivariable analyses revealed an inverse association of baseline TT, free T, and DHEAS concentrations with change in fibrinogen levels (per SD decrement in TT, 0.25 [95% confidence interval, 0.04-0.45]; in free T, 0.30 [0.09-0.51]; and in DHEAS, 0.23 [0.11-0.36]). Furthermore, baseline DHEAS concentrations were inversely associated with change in WBC levels (per SD decrement, 0.53 [0.24-0.82]). Baseline TT, SHBG, free T, and DHEAS concentrations were also inversely associated with change in GGT after multivariable adjustment. The present study is the first to demonstrate prospective inverse associations between sex hormone concentrations and markers of inflammation and oxidative stress in men. Additional studies are warranted to elucidate potential mechanisms underlying the revealed associations.
C1 [Haring, Robin; Nauck, Matthias; Wallaschofski, Henri] Univ Med Greifswald, Inst Clin Chem & Lab Med, D-17475 Greifswald, Germany.
   [Baumeister, Sebastian E.; Voelzke, Henry] Univ Med Greifswald, Inst Community Med, D-17475 Greifswald, Germany.
   [Doerr, Marcus] Univ Med Greifswald, Dept Cardiol, D-17475 Greifswald, Germany.
   [Kocher, Thomas] Univ Med Greifswald, Det Restorat Dent Periodontol & Endodontol, D-17475 Greifswald, Germany.
C3 Universitat Greifswald; Greifswald Medical School; Universitat
   Greifswald; Greifswald Medical School; Universitat Greifswald;
   Greifswald Medical School; Universitat Greifswald; Greifswald Medical
   School
RP Haring, R (corresponding author), Univ Med Greifswald, Inst Clin Chem & Lab Med, Ferdinand Sauerbruch Str, D-17475 Greifswald, Germany.
EM robin.haring@uni-greifswald.de
RI Baumeister, Sebastian-Edgar/P-7894-2019; Dörr, Marcus/F-1919-2010;
   Wilkening, Robin/J-5535-2018
OI Dorr, Marcus/0000-0001-7471-475X; Wilkening, Robin/0000-0002-8332-5016
FU Federal Ministry of Education and Research; Ministry of Cultural Affairs
   of the Federal State of Mecklenburg-West Pomerania [03IS2061A]; German
   Federal Ministry of Education and Research (BMBF) [01ZZ96030, 01ZZ0701];
   Ministry for Education, Research, and Cultural Affairs; Ministry for
   Social Affairs of the Federal State of Mecklenburg-West Pomerania;
   Ministry of Cultural Affairs of the Federal State of Mecklenburg, West
   Pomerania, Germany; Novo Nordisk
FX This work is part of the research project Greifswald Approach to
   Individualized Medicine (GANI_MED). The GANI_MED consortium is funded by
   the Federal Ministry of Education and Research and the Ministry of
   Cultural Affairs of the Federal State of Mecklenburg-West Pomerania
   (03IS2061A). SHIP is part of the Community Medicine Net
   (http://www.medizin.uni-greifswald.de/icm) of the University of
   Greifswald, which is funded by grants from the German Federal Ministry
   of Education and Research (BMBF, grant 01ZZ96030, 01ZZ0701); the
   Ministry for Education, Research, and Cultural Affairs; and the Ministry
   for Social Affairs of the Federal State of Mecklenburg-West Pomerania.
   This study was carried out in collaboration with the German Centre for
   Cardiovascular Research (GCCR), which is funded by the Federal Ministry
   of Education and Research and the Ministry of Cultural Affairs of the
   Federal State of Mecklenburg, West Pomerania, Germany. Novo Nordisk
   provided partial grant support for the determination of serum samples
   and data analysis.
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NR 50
TC 42
Z9 48
U1 1
U2 8
PU AMER SOC ANDROLOGY, INC
PI LAWRENCE
PA C/O ALLEN PRESS, INC PO BOX 368, LAWRENCE, KS 66044 USA
SN 0196-3635
EI 1939-4640
J9 J ANDROL
JI J. Androl.
PD SEP-OCT
PY 2012
VL 33
IS 5
BP 944
EP 950
DI 10.2164/jandrol.111.015065
PG 7
WC Andrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 005XD
UT WOS:000308782500026
PM 22207707
OA Bronze
DA 2025-06-11
ER

PT J
AU Cohn, AY
   Grant, LK
   Nathan, MD
   Wiley, A
   Abramson, M
   Harder, JA
   Crawford, S
   Klerman, EB
   Scheer, FAJL
   Kaiser, UB
   Rahman, SA
   Joffe, H
AF Cohn, Aviva Y.
   Grant, Leilah K.
   Nathan, Margo D.
   Wiley, Aleta
   Abramson, Mathena
   Harder, Jessica A.
   Crawford, Sybil
   Klerman, Elizabeth B.
   Scheer, Frank A. J. L.
   Kaiser, Ursula B.
   Rahman, Shadab A.
   Joffe, Hadine
TI Effects of Sleep Fragmentation and Estradiol Decline on Cortisol in a
   Human Experimental Model of Menopause
SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Article
DE menopause; cortisol; sleep fragmentation; estradiol; stress;
   hypothalamic-pituitary adrenal axis
ID PITUITARY-ADRENAL AXIS; NOCTURNAL HOT FLASHES; SALIVARY CORTISOL;
   BINDING GLOBULIN; HORMONE AGONIST; SEX-DIFFERENCES; MIDLIFE WOMEN;
   LEPTIN LEVELS; ESTROGEN; RESTRICTION
AB Context Perturbations to the hypothalamic-pituitary-adrenal (HPA) axis have been hypothesized to increase postmenopausal cardiometabolic risk. Although sleep disturbance, a known risk factor for cardiometabolic disease, is prevalent during the menopause transition, it is unknown whether menopause-related sleep disturbance and estradiol decline disturb the HPA axis. Objective We examined the effect of experimental fragmentation of sleep and suppression of estradiol as a model of menopause on cortisol levels in healthy young women. Methods Twenty-two women completed a 5-night inpatient study during the mid-to-late follicular phase (estrogenized). A subset (n = 14) repeated the protocol after gonadotropin-releasing hormone agonist-induced estradiol suppression. Each inpatient study included 2 unfragmented sleep nights followed by 3 experimental sleep fragmentation nights. This study took place with premenopausal women at an academic medical center. Interventions included sleep fragmentation and pharmacological hypoestrogenism, and main outcome measures were serum bedtime cortisol levels and cortisol awakening response (CAR). Results Bedtime cortisol increased 27% (P = .03) and CAR decreased 57% (P = .01) following sleep fragmentation compared to unfragmented sleep. Polysomnographic-derived wake after sleep-onset (WASO) was positively associated with bedtime cortisol levels (P = .047) and negatively associated with CAR (P < .01). Bedtime cortisol levels were 22% lower in the hypoestrogenized state compared to the estrogenized state (P = .02), while CAR was similar in both estradiol conditions (P = .38). Conclusion Estradiol suppression and modifiable menopause-related sleep fragmentation both independently perturb HPA axis activity. Sleep fragmentation, commonly seen in menopausal women, may disrupt the HPA axis, which in turn may lead to adverse health effects as women age.
C1 [Cohn, Aviva Y.; Kaiser, Ursula B.] Harvard Med Sch HMS, Brigham & Womens Hosp BWH, Div Endocrinol Diabet & Hypertens, Boston, MA 02115 USA.
   [Cohn, Aviva Y.; Nathan, Margo D.; Wiley, Aleta; Abramson, Mathena; Harder, Jessica A.; Joffe, Hadine] HMS, Dept Psychiat, Womens Hormones & Aging Res Program, BWH, Boston, MA 02115 USA.
   [Cohn, Aviva Y.; Grant, Leilah K.; Wiley, Aleta; Abramson, Mathena; Klerman, Elizabeth B.; Joffe, Hadine] HMS, Connors Ctr Womens Hlth & Gender Biol, BWH, Boston, MA 02115 USA.
   [Grant, Leilah K.; Klerman, Elizabeth B.; Scheer, Frank A. J. L.; Rahman, Shadab A.] BWH, Dept Med & Neurol, Div Sleep & Circadian Disorders, Boston, MA 02115 USA.
   [Grant, Leilah K.; Klerman, Elizabeth B.; Scheer, Frank A. J. L.; Rahman, Shadab A.] HMS, Div Sleep Med, Boston, MA 02115 USA.
   [Crawford, Sybil] UMass Chan Med Sch, Tan Chingfen Grad Sch Nursing, Worcester, MA 01605 USA.
   [Klerman, Elizabeth B.] HMS, Massachusetts Gen Hosp, Dept Neurol, Boston, MA 02114 USA.
   [Joffe, Hadine] Brigham & Womens Hosp, Dept Psychiat, Womens Hormones & Aging Res Program, 75 Francis St,Thorn 11-11, Boston, MA 02115 USA.
C3 Harvard University; Harvard Medical School; Harvard University Medical
   Affiliates; Brigham & Women's Hospital; Harvard University; Harvard
   University Medical Affiliates; Brigham & Women's Hospital; Harvard
   Medical School; Harvard University; Harvard University Medical
   Affiliates; Brigham & Women's Hospital; Harvard University; Harvard
   Medical School; University of Massachusetts System; UMass Chan Medical
   School; University of Massachusetts Worcester; Harvard University;
   Harvard University Medical Affiliates; Massachusetts General Hospital;
   Harvard Medical School; Harvard University; Harvard University Medical
   Affiliates; Brigham & Women's Hospital
RP Joffe, H (corresponding author), Brigham & Womens Hosp, Dept Psychiat, Womens Hormones & Aging Res Program, 75 Francis St,Thorn 11-11, Boston, MA 02115 USA.
EM hjoffe@bwh.harvard.edu
RI Joffe, Hadine/T-6062-2019; Scheer, Frank/C-2795-2012
OI Scheer, Frank/0000-0002-2014-7582; Nathan, Margo/0000-0003-4347-4874;
   Grant, Leilah/0000-0002-6165-7044
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NR 49
TC 7
Z9 7
U1 1
U2 14
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0021-972X
EI 1945-7197
J9 J CLIN ENDOCR METAB
JI J. Clin. Endocrinol. Metab.
PD OCT 18
PY 2023
VL 108
IS 11
BP E1347
EP E1357
DI 10.1210/clinem/dgad285
EA MAY 2023
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA U6GD5
UT WOS:001002214600001
PM 37207451
OA Green Published
DA 2025-06-11
ER

PT J
AU Unlu, M
   Karaman, M
   Ay, SA
   Balta, S
   Cakar, M
   Demirkol, S
   Celik, T
   Arslan, E
   Demirbas, S
   Turker, T
   Yaman, H
   Bulucu, F
   Saglam, K
AF Unlu, Murat
   Karaman, Murat
   Ay, Seyit Ahmet
   Balta, Sevket
   Cakar, Mustafa
   Demirkol, Sait
   Celik, Turgay
   Arslan, Erol
   Demirbas, Seref
   Turker, Turker
   Yaman, Halil
   Bulucu, Fatih
   Saglam, Kenan
TI The Comparative Effects of Valsartan and Amlodipine on Vascular
   Microinflammation in Newly Diagnosed Hypertensive Patients
SO CLINICAL AND EXPERIMENTAL HYPERTENSION
LA English
DT Article
DE pentraxin; C-reactive protein; inflammation; amlodipine; valsartan;
   hypertension
ID C-REACTIVE PROTEIN; LONG PENTRAXIN PTX3; BLOOD-PRESSURE;
   CARDIOVASCULAR-DISEASE; RENAL-FUNCTION; INFLAMMATION; ATHEROSCLEROSIS;
   RECOGNITION; REGRESSION; STRESS
AB Pentraxin 3 (PTX3) is a new candidate immunoinflammatory marker that has been reported to be associated with cardiometabolic risk factors. We aimed to investigate the effects of valsartan and amlodipine on the PTX3 and C-reactive protein (CRP) levels in patients with essential hypertension. Patients with a newly diagnosed essential hypertension were admitted to our internal medicine outpatient clinic. Patients were randomized to one of the following intervention protocols: calcium channel blocker (amlodipine, 5-10 mg/day) as group A (n = 22; mean age +/- standard deviation [SD]: 52 +/- 11 year) and angiotensine II receptor blocker (valsartan, 80-320 mg/day) as group B (n = 28; mean age +/- SD: 50 +/- 14 year). Endothelial dysfunction and systemic inflammation were evaluated with PTX3 and CRP. There was a significant decrease in the level of PTX3 after treatment in two groups (P < .05). Although there was a significant decrease in the level of CRP after treatment in amlodipine group, there was no significant decrease in the levels of PTX3 and CRP after treatment in two groups. There were no significant differences in the systolic and diastolic blood pressure reduction between the two treatment groups. In the treatment of hypertension, prior knowledge of the level of plasma PTX3 could be important in antihypertensive drug choice. C-reactive protein and PTX3 are the markers that have role in vascular inflammation and are found associated with the prognosis of cardiovascular outcomes in many trials. In our study, PTX and CRP levels were decreased when compared to baseline levels.
C1 [Unlu, Murat] Beytepe Hosp, Dept Cardiol, Ankara, Turkey.
   [Karaman, Murat; Ay, Seyit Ahmet; Cakar, Mustafa; Arslan, Erol; Demirbas, Seref; Bulucu, Fatih; Saglam, Kenan] Gulhane Mil Med Acad, Dept Internal Med, Ankara, Turkey.
   [Balta, Sevket; Demirkol, Sait; Celik, Turgay] Gulhane Mil Med Acad, Dept Cardiol, Ankara, Turkey.
   [Turker, Turker] Gulhane Mil Med Acad, Dept Publ Hlth, Ankara, Turkey.
   [Yaman, Halil] Gulhane Mil Med Acad, Dept Med Biochem, Ankara, Turkey.
C3 Ankara Beytepe Murat Erdi Eker State Hospital; Gulhane Military Medical
   Academy; Gulhane Military Medical Academy; Gulhane Military Medical
   Academy; Gulhane Military Medical Academy
RP Karaman, M (corresponding author), Gulhane Mil Med Acad, Dept Internal Med, Tevfik Saglam St, TR-06018 Etlik, Turkey.
EM drmuratkaraman@gmail.com
RI Sağlam, Kenan/GPP-7578-2022; Çakar, Mustafa/D-8282-2015; Celik,
   Turgay/I-2981-2019
OI Saglam, Kenan/0000-0003-2543-8853; Celik, Turgay/0000-0001-8418-0130;
   Balta, Sevket/0000-0002-6657-7334
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NR 31
TC 36
Z9 37
U1 0
U2 10
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1064-1963
EI 1525-6006
J9 CLIN EXP HYPERTENS
JI Clin. Exp. Hypertens.
PY 2013
VL 35
IS 6
BP 418
EP 423
DI 10.3109/10641963.2012.739237
PG 6
WC Pharmacology & Pharmacy; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Cardiovascular System & Cardiology
GA 220XE
UT WOS:000324619800005
PM 23148500
DA 2025-06-11
ER

PT J
AU Li, XL
   Luo, M
   Zeng, YM
   Zhang, RY
   Lin, XC
   Du, YJ
   Zhao, W
   Feng, QJ
   Wu, MH
   Zhang, J
   Guo, L
   Wu, PL
   Yang, CY
   Cai, FF
   Wang, Y
   Hu, YX
   Wang, HY
   Liu, NN
   Xu, LL
   Guan, MP
AF Li, Xuelin
   Luo, Min
   Zeng, Yanmei
   Zhang, Renyi
   Lin, Xiaochun
   Du, Yuejun
   Zhao, Wei
   Feng, Qijian
   Wu, Minghai
   Zhang, Jin
   Guo, Lei
   Wu, Peili
   Yang, Chuyi
   Cai, Feifei
   Wang, Yuan
   Hu, Yuxuan
   Wang, Huiyun
   Liu, Nannan
   Xu, Lingling
   Guan, Meiping
TI MicroRNA-24-3p targeting Top1 in perirenal fat is involved in
   circulating inflammation and high cardiovascular disease risk in
   patients with primary aldosteronism
SO JOURNAL OF TRANSLATIONAL MEDICINE
LA English
DT Article
DE Primary aldosteronism; Cardiovascular disease; Perirenal fat; MiR-24-3p;
   Inflammation; Oxidative stress
ID ADIPOSE-TISSUE; TOPOISOMERASE-I; EXPRESSION; DIFFERENTIATION;
   INTERLEUKIN-6; DIAGNOSIS; RECEPTOR; EVENTS; CELLS
AB ContextPatients with primary aldosteronism (PA) are at a high risk of cardiovascular diseases (CVD) and metabolic syndrome. Notable inflammatory and fibrotic changes and differential microRNA (miRNA) expression profiles in the perirenal fat observed in PA may contribute to this increased risk, however, which has not been fully elucidated.ObjectiveThis study aimed to explore the role of high expression of miR-24-3p in perirenal fat in circulating inflammation and its correlation with a high risk of CVD in patients with PA.MethodsPerirenal fat thickness (PRFT) measured by computed tomography (CT), miR-24-3p expression in perirenal fat, circulating inflammatory factors from adrenal veins and peripheral blood in patients with PA were analyzed. In vitro, white and brown adipocytes with miR-24-3p overexpression or inhibition respectively were stimulated with aldosterone and a unidirectional co-culture model of adipocytes and HUVEC was established. The target genes of miR-24-3p were identified.ResultsPatients with PA and CVD have significantly higher PRFT than those without CVD. The expression level of miR-24-3p in perirenal fat was significantly positively correlated with PRFT. MiR-24-3p was significantly upregulated in the perirenal fat of PA and was associated with increased adipogenesis, inflammation, and oxidative stress, correlating with plasma aldosterone concentration (PAC), PRFT, cardiac remodeling, and weight gain. The IL-6 level in the peripheral blood was elevated in patients with PA and CVD, and the affected adrenal vein had the highest IL-6 level. Targeting Top1, miR-24-3p modulated aldosterone-induced effects in adipocytes and influenced IL-6 secretion, thereby affecting HUVEC.ConclusionThe upregulation of miR-24-3p in the perirenal fat induced inflammation and oxidative stress by targeting Top1, which may contribute to a high risk of CVD in patients with PA.
C1 [Li, Xuelin; Zeng, Yanmei; Lin, Xiaochun; Feng, Qijian; Wu, Minghai; Zhang, Jin; Guo, Lei; Wu, Peili; Yang, Chuyi; Cai, Feifei; Wang, Yuan; Hu, Yuxuan; Wang, Huiyun; Liu, Nannan; Guan, Meiping] Southern Med Univ, Nanfang Hosp, Dept Endocrinol & Metab, Guangzhou, Guangdong, Peoples R China.
   [Li, Xuelin; Xu, Lingling] Southern Med Univ, Shenzhen Hosp, Dept Endocrinol, Shenzhen, Peoples R China.
   [Luo, Min] Southern Med Univ, Nanfang Hosp, Dept Lab Med, Guangzhou, Guangdong, Peoples R China.
   [Zhang, Renyi] Southern Med Univ, Nanfang Hosp, Dept Gen Surg, Guangzhou, Guangdong, Peoples R China.
   [Du, Yuejun] Southern Med Univ, Nanfang Hosp, Div Urol, Guangzhou, Guangdong, Peoples R China.
   [Zhao, Wei] Southern Med Univ, Nanfang Hosp, Div Vasc & Intervent Radiol, Guangzhou, Guangdong, Peoples R China.
C3 Southern Medical University - China; Southern Medical University -
   China; Southern Medical University - China; Southern Medical University
   - China; Southern Medical University - China; Southern Medical
   University - China
RP Guan, MP (corresponding author), Southern Med Univ, Nanfang Hosp, Dept Endocrinol & Metab, Guangzhou, Guangdong, Peoples R China.
EM mpguan@163.com
FU National Natural Science Foundation of China
FX We are very grateful to Prof. Hongbin Zhang (Denmark), Prof. Yuhua Tseng
   (Joslin Diabetes Center, Harvard Medical School) and Prof. Huijie Zhang
   (Nanfang Hospital).
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NR 48
TC 0
Z9 0
U1 2
U2 2
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1479-5876
J9 J TRANSL MED
JI J. Transl. Med.
PD MAR 18
PY 2025
VL 23
IS 1
AR 345
DI 10.1186/s12967-025-06329-1
PG 18
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 0HG9Z
UT WOS:001447345600001
PM 40102901
OA gold
DA 2025-06-11
ER

PT J
AU Li, Q
   Zheng, YB
   Zhao, JY
   Wei, XY
   Shi, ZX
   Fan, HA
   Ge, CX
   Xu, MX
   Tan, J
AF Li, Qiang
   Zheng, Yanbin
   Zhao, Jianyu
   Wei, Xinyi
   Shi, Zongxin
   Fan, Haonan
   Ge, Chenxu
   Xu, Minxuan
   Tan, Jun
TI Radish red attenuates chronic kidney disease in obese mice through
   repressing oxidative stress and ferroptosis via Nrf2 signaling
   improvement
SO INTERNATIONAL IMMUNOPHARMACOLOGY
LA English
DT Article
DE Chronic kidney disease (CKD); Radish red (RR); Oxidative stress; Nrf2;
   Ferroptosis
ID INSULIN-RESISTANCE; METABOLIC SYNDROME; FATTY-ACIDS; ANTHOCYANINS;
   INFLAMMATION; INJURY; INHIBITION; MECHANISMS; PATHWAY; LIVER
AB Chronic kidney disease (CKD) presents a significant public health concern, with obesity being a prominent contributing factor to kidney disorders by inducing oxidative stress, lipotoxicity, and tubular cell injury. Natural anthocyanins extracted from red radishes (Raphanus sativus L.) exert antioxidant and anti-apoptotic functions. This study aims to employ a novel natural pigment anthocyanin, referred to as radish red (RR) isolated from red radishes, to alleviate obesity-related metabolic disturbances and kidney impairment in a CKD mouse model induced by high-fat and high-fructose diets (HFFD). The in vitro study initially demonstrated that RR treatment significantly mitigated the palmitate acid (PA)-induced injury and cytotoxicity in human tubular epithelial HK2 cells. Subsequently, RR supplementation notably improved obesity and associated metabolic dysfunctions in mice caused by HFFD. Abnormal renal function indices including serum creatinine, blood urea nitrogen (BUN), uric acid (UA), urine protein, albuminuria and urine albumin-to-creatinine ratio (UACR) were detected in HFFDfed mice, which were effectively alleviated by RR treatment. Histologically, renal tubular cell injury, lipid deposition, tubular dilatation, and renal fibrosis induced by HFFD were markedly improved after RR administration in mice. Furthermore, RR treatment significantly alleviated oxidative stress in HFFD-fed mice, as evidenced by the decreased renal reactive oxygen species (ROS) production, 4-HNE, and NOX4 expression levels. Anti-oxidants such as superoxide dismutase-1 (SOD1), NAD (P) H: quinone oxidoreductase (NQO1), heme oxygenase-1 (HO-1) and glutamate cysteine ligase (GCLC) were highly upregulated in kidney of HFFD-fed mice with RR consumption through improving NFE2-related factor 2 (Nrf2) signaling activation. Furthermore, ferroptosis was identified in the kidneys of HFFD-fed mice, evidenced by the elevated levels of malondialdehyde (MDA), iron content, and lipid peroxidation, along with the decreased expression of glutathione peroxidase 4 (GPX4) and solute carrier family 7 member 11 (SLC7A11). These occurrences were significantly mitigated following RR treatment. Mechanistically, we further discovered that the suppressive effects of RR in restricting oxidative stress, ferroptosis, lipid accumulation, and injury of tubular epithelial cells induced by PA were significantly counteracted by Nrf2 knockdown. Collectively, our results demonstrated that dietary supplementation with RR could potentially serve as an efficacious therapeutic modality for the management of obesityrelated CKD progression by enhancing Nrf2 activation to impede oxidative stress and ferroptosis.
C1 [Li, Qiang; Zheng, Yanbin; Zhao, Jianyu; Wei, Xinyi; Shi, Zongxin; Fan, Haonan; Ge, Chenxu; Xu, Minxuan; Tan, Jun] Chongqing Univ Educ, Sch Biol & Chem Engn, Chongqing Key Lab Med Resources Three Gorges Reser, Chongqing 400067, Peoples R China.
   [Li, Qiang; Zheng, Yanbin; Zhao, Jianyu; Wei, Xinyi; Shi, Zongxin; Fan, Haonan; Ge, Chenxu; Xu, Minxuan; Tan, Jun] Chongqing Univ Educ, Coll Modern Hlth Ind, Chongqing 400067, Peoples R China.
   [Ge, Chenxu; Xu, Minxuan; Tan, Jun] Chongqing Univ, Coll Bioengn, Key Lab Biorheol Sci & Technol, Minist Educ, Chongqing 400030, Peoples R China.
C3 Chongqing University of Education; Chongqing University of Education;
   Ministry of Education - China; Chongqing University
RP Ge, CX; Xu, MX; Tan, J (corresponding author), Chongqing Univ Educ, Sch Biol & Chem Engn, Chongqing Key Lab Med Resources Three Gorges Reser, Chongqing 400067, Peoples R China.
EM 948868932@qq.com; minxuanxu@foxmail.com; tanjun@cque.edu.cntanj
RI Zhao, Jianyu/AAW-7608-2021
OI Xu, Minxuan/0000-0002-0742-4717
FU National Natural Science Foundation of China [82200652]; The 2024
   Science and Technology Research Program of Chongqing Education
   Commission of China [KJZDM202401602]; University-level Major scientific
   Research Projects and Landmark Scientific Research Achievement Awards
   Cultivation and Funding Projects [XJZDKYPYXM01]; Research Project of
   Chongqing University of Education [KY202121C]; Chongqing
   Entrepreneurship and Innovation Support Program for Overseas Returnees
   [CX2023011]; Chongqing Natural Science Fund Inno-vation and Development
   Joint Fund [CSTB2022NSCQ-MSX0240]
FX (1) National Natural Science Foundation of China (Grant No.: 82200652) ;
   (2) Science and Technology Research Program of Chongqing Education
   Commission of China (Grant No.: KJZDM202401602) ; (3) 2024
   University-level Major scientific Research Projects and Landmark
   Scientific Research Achievement Awards Cultivation and Funding Projects
   (Grant No.: XJZDKYPYXM01) ; (4) Research Project of Chongqing University
   of Education (Grant No.: KY202121C) ; (5) Chongqing Entrepreneurship and
   Innovation Support Program for Overseas Returnees (CX2023011) and (6)
   Chongqing Natural Science Fund Innovation and Development Joint Fund
   (Grant No.: CSTB2022NSCQ-MSX0240) .
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NR 95
TC 2
Z9 2
U1 7
U2 7
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1567-5769
EI 1878-1705
J9 INT IMMUNOPHARMACOL
JI Int. Immunopharmacol.
PD DEC 25
PY 2024
VL 143
AR 113385
DI 10.1016/j.intimp.2024.113385
EA NOV 2024
PN 3
PG 19
WC Immunology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Pharmacology & Pharmacy
GA M7F9J
UT WOS:001359165200001
PM 39549542
DA 2025-06-11
ER

PT J
AU Kim, SY
   Bang, W
   Choi, HG
AF Kim, So Young
   Bang, Woojin
   Choi, Hyo Geun
TI Analysis of the prevalence and associated factors of overactive bladder
   in adult Korean men
SO PLOS ONE
LA English
DT Article
ID URINARY-TRACT SYMPTOMS; QUALITY-OF-LIFE; RISK-FACTORS; UNITED-STATES;
   METABOLIC SYNDROME; PHYSICAL-ACTIVITY; POPULATION; IMPACT; WOMEN;
   INCONTINENCE
AB Overactive bladder (OAB) is a prevalent condition characterized by lower urinary tract symptoms (LUTS). Age, education, income, marital status, sleep, and emotional problems have been associated with OAB; however, conflicting results exist. The present study was conducted to estimate the prevalence of OAB and comprehensively analyze its associated factors in a large cross-sectional, population-based study. The data of 94,554 participants aged 19- 107 were analyzed from the Korean Community Health Survey (KCHS) of 2012. Data on marital status, physical activity, education level, occupation, body mass index (BMI), income level, sleep time, and stress level were retrieved for all enrolled participants. The overactive bladder symptom score (OABSS) was used to evaluate the presence and degree of OAB. Simple and multiple logistic regression analyses with complex sampling were used for the associations between various factors and the presence of OAB. Overall, OAB was present in approximately 2.9% of the participants. The prevalence of OAB increased with age and steeply increased after 60 years of age (adjusted odds ratio [AOR] for each 10 years = 1.70, 95% confidence interval [CI] = 1.61-1.80, P<0.001). The prevalence of OAB was lower in married than unmarried subjects (AOR = 0.59, 95% CI = 0.48-0.72, P<0.001). The prevalence of OAB was significantly different according to occupation Compared to manager, expert, specialist, clerk group, the prevalence of OAB was highest in unemployed group (AOR = 1.90, 95% CI = 1.55-2.32, P < 0.001). Being underweight was correlated with OAB (AOR = 1.29, 95% CI = 1.08-1.55, P = 0.018). Inadequate sleep showed a significant association with OAB (AOR = 1.13, 95% CI = 1.02-1.25 for <= 6 hours of sleep time and AOR = 1.53, 95% CI = 1.27-1.86 for >= 9 hours of sleep, P<0.001). Stress level showed a dose-dependent positive association with OAB [AOR (95% CI) = 3.91 (3.13-4.89) > 2.16 (1.88-2.48) > 1.39 (1.23-1.57) for severe stress > moderate stress > some stress, respectively, P<0.001]. A medical history of diabetes mellitus, hyperlipidemia, and/or cerebral stroke was significantly related to OAB. Approximately 2.9% of adult Korean men experienced OAB based on the OABSS. Unmarried status; occupation; being underweight; inadequate sleep; stress; and medical history of diabetes mellitus, hyperlipidemia, or cerebral stroke were significantly correlated with OAB.
C1 [Kim, So Young] CHA Univ, CHA Bundang Med Ctr, Dept Otorhinolaryngol Head & Neck Surg, Seongnam, South Korea.
   [Bang, Woojin] Hallym Univ, Dept Urol, Sacred Heart Hosp, Anyang, South Korea.
   [Choi, Hyo Geun] Hallym Univ, Coll Med, Dept Otorhinolaryngol Head & Neck Surg, Anyang, South Korea.
C3 Pochon Cha University; Hallym University; Hallym University
RP Choi, HG (corresponding author), Hallym Univ, Coll Med, Dept Otorhinolaryngol Head & Neck Surg, Anyang, South Korea.
EM pupen@naver.com
RI Choi, Hyo/K-4461-2019; Kim, So-Young/JFS-7698-2023
OI Choi, Hyo Geun/0000-0003-1655-9549
FU National Research Foundation (NRF) of Korea [NRF-2015-R1D1A1A01060860];
   Hallym University Sacred Heart Hospital [HURF-2016-38]
FX This work was supported in part by a research grant
   (NRF-2015-R1D1A1A01060860) from the National Research Foundation (NRF)
   of Korea and a Research Grant funded by Hallym University Sacred Heart
   Hospital (HURF-2016-38) to HGC. The funders had no role in study design,
   data collection and analysis, decision to publish, or preparation of the
   manuscript.
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NR 48
TC 18
Z9 18
U1 0
U2 5
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD APR 13
PY 2017
VL 12
IS 4
AR e0175641
DI 10.1371/journal.pone.0175641
PG 14
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA ET0MB
UT WOS:000399955400076
PM 28407021
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Yang, Z
   Chen, Q
   Wang, JM
   Qiu, YN
   Thepsuwan, P
   Yi, ZP
   Heng, HH
   Sun, QH
   Chen, XQ
   Li, L
   He, PJ
   Zhang, R
   Zhang, KZ
AF Yang, Zhao
   Chen, Qi
   Wang, Jiemei
   Qiu, Yining
   Thepsuwan, Pattaraporn
   Yi, Zhengping
   Heng, Henry H.
   Sun, Qinghua
   Chen, Xuequn
   Li, Li
   He, Peijian
   Zhang, Ren
   Zhang, Kezhong
TI Inhalation exposure to airborne PM2.5 attenuates hepatic
   metabolic pathways through S-nitrosylation of the primary ER
   stress sensor
SO AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
LA English
DT Article
DE airborne fine particulate matter; MASH; nitrosative stress; unfolded
   protein response; microRNA degradation
ID ENDOPLASMIC-RETICULUM STRESS; UNFOLDED PROTEIN RESPONSE; PARTICULATE
   MATTER; AIR-POLLUTION; INFLAMMATION; PARTICLES; ATHEROSCLEROSIS;
   DYSFUNCTION; ACTIVATION; DISEASE
AB Inhalation exposure to airborne fine particulate matter (aerodynamic diameter: <2.5 <mu>m, PM2.5) is known to cause metabolic dysfunction-associated steatohepatitis (MASH) and the associated metabolic syndrome. Hepatic lipid accumulation and inflammation are the key characteristics of MASH. However, the mechanism by which PM2.5 exposure induces lipid accumulation and inflammation in the liver remains to be further elucidated. In this study, we revealed that inhalation exposure to PM2.5 induces nitrosative stress in mouse livers by suppressing hepatic S-nitrosoglutathione reductase activities, which leads to S-nitrosylation modification of the primary unfolded protein response (UPR) transducer inositol-requiring 1 alpha (IRE1 alpha), an endoplasmic reticulum-resident protein kinase and endoribonuclease (RNase). S-nitrosylation suppresses the RNase activity of IRE1 alpha and subsequently decreases IRE1 alpha-mediated splicing of the mRNA encoding X-box binding protein 1 (XBP1) and IRE1 alpha-dependent degradation of select microRNAs (miRNAs), including miR-200 family members, miR-34, miR-223, miR-155, and miR-146, in the livers of the mice exposed to PM2.5. Elevation of IRE1 alpha-target miRNAs, due to impaired IRE1 alpha RNase activity by PM2.5-triggered S-nitrosylation, leads to decreased expression of the major regulators of fatty acid oxidation, lipolysis, and anti-inflammatory response, including XBP1, sirtuin 1, peroxisome proliferator-activated receptor alpha, and peroxisome proliferator-activated receptor gamma, in the liver, which account at least partially for hepatic lipid accumulation and inflammation in mice exposed to airborne PM2.5. In summary, our study revealed a novel pathway by which PM2.5 causes cytotoxicity and promotes MASH-like phenotypes through inducing hepatic nitrosative stress and S-nitrosylation of the primary UPR transducer and subsequent elevation of select miRNAs involved in metabolism and inflammation in the liver. NEW & NOTEWORTHY Exposure to fine airborne particulate matter PM2.5 causes metabolic dysfunction-associated steatohepatitis characterized by hepatic steatosis, inflammation, and fibrosis. Here, we discovered that inhalation exposure to environmental PM2.5 induces nitrosative stress in livers by suppressing hepatic S-nitrosoglutathione reductase activities, which leads to S-nitrosylation of the unfolded protein response transducer IRE1 alpha. S-nitrosylation decreases IRE1 alpha-dependent degradation of miRNAs in the livers of mice exposed to PM2.5, leading to downregulation of major regulators of energy metabolism and anti-inflammatory response.
C1 [Yang, Zhao; Chen, Qi; Wang, Jiemei; Qiu, Yining; Thepsuwan, Pattaraporn; Heng, Henry H.; Li, Li; Zhang, Ren; Zhang, Kezhong] Wayne State Univ, Ctr Mol Med & Genet, Sch Med, Detroit, MI 48202 USA.
   [Zhang, Kezhong] Wayne State Univ, Dept Biochem Microbiol & Immunol, Sch Med, Detroit, MI 48202 USA.
   [Sun, Qinghua] Ohio State Univ, Coll Publ Hlth, Div Environm Hlth Sci, Columbus, OH USA.
   [Chen, Xuequn] Wayne State Univ, Dept Physiol, Sch Med, Detroit, MI USA.
   [Wang, Jiemei; Yi, Zhengping] Wayne State Univ, Eugene Applebaum Coll Pharm Hlth Sci, Dept Pharmaceut Sci, Detroit, MI USA.
   [He, Peijian] Emory Univ, Dept Med, Div Digest Dis, Sch Med, Atlanta, GA USA.
C3 Wayne State University; Wayne State University; University System of
   Ohio; Ohio State University; Wayne State University; Wayne State
   University; Emory University
RP Zhang, KZ (corresponding author), Wayne State Univ, Ctr Mol Med & Genet, Sch Med, Detroit, MI 48202 USA.; Zhang, KZ (corresponding author), Wayne State Univ, Dept Biochem Microbiol & Immunol, Sch Med, Detroit, MI 48202 USA.
EM kzhang@med.wayne.edu
RI Heng, Henry/HMV-1721-2023; Wang, Jiemei/N-9528-2019; Sun,
   Qinghua/E-4167-2011; WANG, JIEMEI/D-6317-2012
OI WANG, JIEMEI/0000-0002-8723-4410
FU National Institutes of Health (NIH) [DK090313, DK126908, DK132065]
FX This work is partially supported by the National Institutes of Health
   (NIH) Grant DK090313 (to K.Z.), Grant DK126908 (to K.Z.), and Grant
   DK132065 (to R.Z. and K.Z.).
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NR 59
TC 0
Z9 0
U1 1
U2 1
PU AMER PHYSIOLOGICAL SOC
PI Rockville
PA 6120 Executive Blvd, Suite 600, Rockville, MD, UNITED STATES
SN 0363-6143
EI 1522-1563
J9 AM J PHYSIOL-CELL PH
JI Am. J. Physiol.-Cell Physiol.
PD JAN 28
PY 2025
VL 328
IS 1
BP C212
EP C226
DI 10.1152/ajpcell.00385.2024
PG 15
WC Cell Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Physiology
GA 0ZM5B
UT WOS:001459711300001
PM 39607384
DA 2025-06-11
ER

PT J
AU Andica, C
   Kamagata, K
   Takabayashi, K
   Kikuta, J
   Kaga, H
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   Aoki, S
AF Andica, Christina
   Kamagata, Koji
   Takabayashi, Kaito
   Kikuta, Junko
   Kaga, Hideyoshi
   Someya, Yuki
   Tamura, Yoshifumi
   Kawamori, Ryuzo
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   Naganawa, Shinji
   Aoki, Shigeki
TI Neuroimaging findings related to glymphatic system alterations in older
   adults with metabolic syndrome
SO NEUROBIOLOGY OF DISEASE
LA English
DT Article
DE Cognition; Diffusion-weighted imaging; Diffusion tensor imaging-along
   the perivascular; space; Free water imaging; Glymphatic system;
   Metabolic syndrome
ID TRANSGENIC MOUSE MODEL; INSULIN-RESISTANCE; OXIDATIVE STRESS; DIFFUSION;
   MEMORY; ASSOCIATION; AMYLOIDOSIS; IMPAIRMENT; IMAGES; SLEEP
AB Objective: The glymphatic system is a glial-based perivascular network that promotes brain metabolic waste clearance. Reduced glymphatic flow has been observed in rat models of type 2 diabetes and hypertension, indicating the role of vascular risk factors in the glymphatic system. However, little is known about how vascular risk factors affect the human glymphatic system. The present study aims to assess the relationships between metabolic syndrome (MetS), a cluster of vascular risk factors, and the glymphatic system function using diffusion magnetic resonance imaging (MRI)-based measures of water diffusivity in the glymphatic compartments, including the brain interstitial space and perivascular spaces around the deep medullary vein. We hypothesized that vascular risk factors are associated with glymphatic dysfunction, leading to cognitive impairment in older adults.Methods: This cross-sectional study assessed 61 older adults (age range, 65-82 years) who had participated in the Bunkyo Health Study, including 15 healthy controls (mean age, 70.87 +/- 4.90 years) and 46 individuals with MetS (mean age, 71.76 +/- 4.61 years). Fractional volume of extracellular-free water (FW) and an index of diffusion tensor imaging along the perivascular space (DTI-ALPS) were used as indirect indicators of water diffusivity in the interstitial extracellular and perivenous spaces of white matter, respectively. Results: After adjusting for age, sex, years of education, total Fazekas scale, Pittsburgh sleep quality index (PSQI) score, and intracranial volume (ICV), a significantly (P = 0.030; Cohen's d = 1.01) higher FW was observed in individuals with MetS than in the healthy controls. Furthermore, individuals with MetS had a significantly (P = 0.031; Cohen's d = 0.86) lower ALPS index than the healthy controls, with age, sex, years of education, total Fazekas scale, PSQI score, ICV, fractional anisotropy, and mean diffusivity included as confounding factors. Higher FW was significantly associated with lower ALPS index (r = -0.37; P = 0.004). Multiple linear regression (MLR) with backward elimination analyses showed that higher diastolic blood pressure (BP; standardized beta = 0.33, P = 0.005) was independently associated with higher FW, whereas higher fasting plasma glucose levels (standardized beta = -0.63, P = 0.002) or higher Brinkman index of cigarette consumption cumulative amount (standardized beta = -0.27, P = 0.022) were associated with lower ALPS index. The lower ALPS index (standardized beta, 0.28; P = 0.040) was associated with poorer global cognitive performance, which was determined using the Japanese version of the Montreal Cognitive Assessment (MOCA-J) scores. Finally, partial correlation analyses showed a significant correlation between higher FW and lower MOCA-J scores (r =-0.35; P = 0.025) and between higher FW and higher diastolic BP (r = 0.32, P = 0.044).Conclusion: The present study shows the changes in diffusion MRI-based measures reflected by the higher FW and lower ALPS index in older adults with MetS, possibly due to the adverse effect of vascular risk factors on the glymphatic system. Our findings also indicate the associations between the diffusion MRI-based measures and elevated diastolic BP, hyperglycemia, smoking habit, and poorer cognitive performance. However, owing to the limitations of this study, the results should be cautiously interpreted.
C1 [Andica, Christina; Aoki, Shigeki] Juntendo Univ, Fac Hlth Data Sci, 6-8-1 Hinode, Urayasu, Chiba 2790013, Japan.
   [Andica, Christina; Kamagata, Koji; Takabayashi, Kaito; Kikuta, Junko; Aoki, Shigeki] Juntendo Univ, Dept Radiol, Grad Sch Med, 2-1-1 Hongo,Bunkyo Ku, Tokyo 1138421, Japan.
   [Kaga, Hideyoshi; Someya, Yuki; Tamura, Yoshifumi; Kawamori, Ryuzo; Watada, Hirotaka] Juntendo Univ, Grad Sch Med, Sportol Ctr, 2-1-1 Hongo,Bunkyo Ku, Tokyo 1130034, Japan.
   [Kaga, Hideyoshi; Tamura, Yoshifumi; Kawamori, Ryuzo; Watada, Hirotaka] Juntendo Univ, Grad Sch Med, Dept Metab & Endocrinol, 2-1-1 Hongo,Bunkyo Ku, Tokyo 1138421, Japan.
   [Taoka, Toshiaki] Nagoya Univ, Grad Sch Med, Dept Innovat Biomed Visualizat, 65 Tsurumai Cho,Showa Ku, Nagoya 4668550, Japan.
   [Naganawa, Shinji] Nagoya Univ, Grad Sch Med, Dept Radiol, 65 Tsurumai Cho,Showa Ku, Nagoya 4668550, Japan.
C3 Juntendo University; Juntendo University; Juntendo University; Juntendo
   University; Nagoya University; Nagoya University
RP Andica, C (corresponding author), Juntendo Univ, Fac Hlth Data Sci, 6-8-1 Hinode, Urayasu, Chiba 2790013, Japan.
EM christina@juntendo.ac.jp
RI Andica, Christina/AAV-1398-2020; Taoka, Toshiaki/A-1637-2016; Tamura,
   Yoshifumi/AFK-2430-2022; Naganawa, Shinji/I-1572-2012; 鎌形,
   康司/AFL-9072-2022; Kikuta, Junko/AAR-4743-2021
OI Kikuta, Junko/0000-0003-1324-8614
FU Juntendo Research Branding Project; Japan Society for the Promotion of
   Science [JP21K07690, 20F20113, JP18H02772, 19K17244]; Promotion and
   Mutual Aid Corporation for Private Schools of Japan; Brain/MINDS Beyond
   program of the Japan Agency for Medical Research and Development
   [JP19dm0307101, JP21wm0425006]
FX This study was partially supported by the Juntendo Research Branding
   Project, the Japan Society for the Promotion of Science Grants-in -Aid
   for Scientific Research (KAKENHI; Grant numbers JP21K07690, 20F20113,
   JP18H02772, and 19K17244) , a Grant -in -Aid for Special Research in
   Subsidies for ordinary expenses of private schools from The Promotion
   and Mutual Aid Corporation for Private Schools of Japan, and the
   Brain/MINDS Beyond program of the Japan Agency for Medical Research and
   Development (Grant numbers JP19dm0307101 and JP21wm0425006) .
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NR 52
TC 41
Z9 41
U1 8
U2 32
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0969-9961
EI 1095-953X
J9 NEUROBIOL DIS
JI Neurobiol. Dis.
PD FEB
PY 2023
VL 177
AR 105990
DI 10.1016/j.nbd.2023.105990
EA JAN 2023
PG 9
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA E5XN4
UT WOS:000976271400001
PM 36621631
OA gold
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Sayampanathan, A
   Ong, JWE
   Ng, YY
   Liu, JM
   Arulanandam, S
   Hee, HI
AF Sayampanathan, Andrew
   Ong, Jordan Wei En
   Ng, Yih Yng
   Liu, Jiaming
   Arulanandam, Shalini
   Hee, Hwan Ing
TI Prevalence and factors associated with cigarette smoking in police
   forces: a systematic review and meta-analysis
SO POLICING-AN INTERNATIONAL JOURNAL OF POLICE STRATEGIES & MANAGEMENT
LA English
DT Review
DE Police; Prevalence; Systematic review; Meta-analysis; Cigarette smoking
ID QUALITY-OF-LIFE; ENVIRONMENTAL TOBACCO-SMOKE; CARDIOVASCULAR RISK;
   METABOLIC SYNDROME; TRAFFIC POLICEMEN; INSULIN-RESISTANCE; URBAN AIR;
   HEALTH; EXPOSURE; STRESS
AB Purpose - The knowledge of cigarette smoking among police forces is limited. The aims of this review were to synthesize the prevalence of cigarette smoking among police forces worldwide and factors associated with cigarette smoking in the police population. Design/methodology/approach - The review was reported according to the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) guidelines. Studies from 1st January 2000 to 7th July 2023 were identified from PubMed, Web of Science and Scopus using search terms: (("cigarette" OR "tobacco" OR "smoke" OR "smoker" OR "smoking") AND ("police" OR "enforcement")). Quality assessment was performed using the Joanna Briggs Institute (JBI) Critical Appraisal Checklist. Pooled prevalence was performed and sub-analysed based on time period, the income group classification of countries and geographical location of countries. A meta-analysis using Mantel-Haenszel statistics and random-effect models was conducted using both RStudio and Review Manager 5.3. Heterogeneity was measured using I-2 statistics. Findings - Data from 105,457 police (55 studies) were included. The prevalence of current smokers among police forces worldwide was 25.28% (95% CI: 20.76-29.79%, I-2: 100%). The smoking prevalence was higher among law enforcement officers than the general population (OR = 2.74, 95% CI = 1.34-5.60, p = 0.006, I-2 = 95%). A declining trend in smoking prevalence was observed based on studies published from 2000 to 2023. By geography, smoking prevalence was lowest in North America, followed by Europe and then Asia. This trend was not impacted by income group, though variations were observed between studies (I-2 > 80%). While there was no gender difference in the odds of smoking (OR = 0.73, 95% CI = 0.40-1.33, p = 0.30, I-2 = 98%), geographic sub-analysis showed that male police were at higher odds of being current smokers than female police in Asia (OR = 9.09, 95% CI = 3.85-25.0, p < 0.001, I-2 = 95%). In contrast, in North America, female police were at higher odds of being current smokers than male police (OR = 1.68, 95% CI = 1.19-2.36, p = 0.003, I-2 = 33%). Factors associated with smoking among police also included operational vocation (OR = 1.23, 95% CI = 1.09-1.40, p = 0.001, I-2 = 0%; compared to administrative roles) and the presence of metabolic syndrome (OR = 1.90, 95% CI = 1.70-2.13, p < 0.001, I-2 = 0%). Research limitations/implications - Law enforcement officers were more likely to smoke than the general population. The prevalence of smoking among police was generally lower in North America, with a decreasing trend in prevalence over time worldwide. This trend was not impacted by the income group of countries. Vocation type and the presence of metabolic syndrome were associated with current smoking and may have implications for occupational medicine in the policing community. Originality/value - This is the first systematic review synthesising data across published literature to identify an aggregate prevalence rate and factors associated with cigarette smoking across police forces.
C1 [Sayampanathan, Andrew] Natl Univ Hlth Syst, Natl Prevent Med Residency, Singapore City, Singapore.
   [Sayampanathan, Andrew; Liu, Jiaming; Arulanandam, Shalini; Hee, Hwan Ing] Minist Home Affairs, Home Team Med Serv Div, Singapore City, Singapore.
   [Ong, Jordan Wei En] Natl Univ Singapore, Yong Loo Lin Sch Med, Singapore City, Singapore.
   [Ng, Yih Yng] Tan Tock Seng Hosp, Dept Prevent & Populat Med, Singapore City, Singapore.
C3 National University of Singapore; National University of Singapore; Tan
   Tock Seng Hospital
RP Sayampanathan, A (corresponding author), Natl Univ Hlth Syst, Natl Prevent Med Residency, Singapore City, Singapore.; Sayampanathan, A (corresponding author), Minist Home Affairs, Home Team Med Serv Div, Singapore City, Singapore.
EM asayampa@gmail.com; E1433675@u.nus.edu; Yih_yng_ng@ttsh.com.sg;
   Liu_jiaming@mha.gov.sg; Shalini_arulanandam@mha.gov.sg;
   Hee_hwan_ing@mha.gov.sg
RI Ng, Yih/AAE-9969-2020
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NR 96
TC 0
Z9 0
U1 1
U2 1
PU EMERALD GROUP PUBLISHING LTD
PI Leeds
PA Floor 5, Northspring 21-23 Wellington Street, Leeds, W YORKSHIRE,
   ENGLAND
SN 1363-951X
EI 1758-695X
J9 POLICING
JI Policing-An Int J Police Strategies & Manag.
PD MAY 22
PY 2025
VL 48
IS 3
BP 580
EP 609
DI 10.1108/PIJPSM-08-2024-0122
EA MAR 2025
PG 30
WC Criminology & Penology
WE Social Science Citation Index (SSCI)
SC Criminology & Penology
GA 2VJ2F
UT WOS:001450312500001
DA 2025-06-11
ER

PT J
AU Vinik, A
   Parson, H
   Ullal, J
AF Vinik, Aaron
   Parson, Henri
   Ullal, Jagdeesh
TI The role of PPARs in the microvascular dysfunction in diabetes
SO VASCULAR PHARMACOLOGY
LA English
DT Review
DE peroxisome proliferator-activated receptors (PPARs); type 2 diabetes;
   microvascular dysfunction
ID NERVE-CONDUCTION-VELOCITY; ENDONEURIAL BLOOD-FLOW; ENDOTHELIAL
   GROWTH-FACTOR; RETRACTED ARTICLE. SEE; NITRIC-OXIDE SYNTHASE;
   HYPERPOLARIZING FACTOR; SURAL NERVE; EPINEURIAL ARTERIOLES;
   ROSIGLITAZONE TREATMENT; CARDIOVASCULAR-DISEASE
AB There is a major defect in skin blood flow (SkBF) in people with type 2 diabetes (T2DM). This defect is associated with relatively normal nitric oxide (NO) production in the skin. The abnormal blood flow cosegregates with hypertension, dyslipidemia, abnormal fatty acid composition, a proinflammatory state, and insulin resistance. Since these covariates are an integral part of the insulin resistance syndrome, we examined the effects of the thiazoledindiones (TZDs) as insulin sensitizers for their ability to correct the abnormal blood flow. The PPAR gamma rosiglitazone improved NO production to normal levels, but had a small effect on SKBF. In contrast, pioglitazone had a small effect on skin neurovascular function but a dramatic effect on reducing nitrosative stress. These effects do not appear to be due to the insulin sensitizing properties of these compounds but are associated with a reduction in indices of inflammation, hemodilution, and are likely to be due to one of the many "vascular" effects of TZDs. The role of inflammation in the disordered neurovascular function in diabetes cannot be underplayed and the possible contribution of PPAR alpha agonists to alter the inflammatory state needs to be explored further. Since blood flow regulation is mediated by mechanisms other than NO, such as prostaglandins and endothelial derived hyperpolarizing factor, which, in turn, are compromised by the inflammatory state, we anticipate that activation of both the PPAR gamma as well as PPAR alpha should ameliorate the disordered blood flow in type 2 diabetes. While it now appears that the PPARs may have a major role to play in protection from macrovascular disease, their contribution to amelioration of the microvascular defects in type 2 diabetes has fallen short of spectacular success. In this respect, the combinations of PPAR alpha, PPAR beta and PPAR gamma may better serve the unique requirements for improving the microvascular defect in diabetes. (c) 2006 Elsevier Inc. All rights reserved.
C1 Eastern Virginia Med Sch, Strelitz Diabet Inst, Norfolk, VA 23510 USA.
C3 Eastern Virginia Medical School
RP Vinik, A (corresponding author), Eastern Virginia Med Sch, Strelitz Diabet Inst, Norfolk, VA 23510 USA.
EM vinikai@evms.edu
RI Ullal, Jagdeesh/AFD-6932-2022
OI Ullal, Jagdeesh/0000-0001-6475-5240
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NR 107
TC 21
Z9 25
U1 0
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1537-1891
EI 1879-3649
J9 VASC PHARMACOL
JI Vasc. Pharmacol.
PD JUL
PY 2006
VL 45
IS 1
SI SI
BP 54
EP 64
DI 10.1016/j.vph.2005.11.012
PG 11
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 064ZZ
UT WOS:000239130500007
PM 16784897
DA 2025-06-11
ER

PT J
AU Bottcher, M
   Madsen, MM
   Randsbæk, F
   Refsgaard, J
   Dorup, I
   Sorensen, K
   Nielsen, TT
AF Bottcher, M
   Madsen, MM
   Randsbæk, F
   Refsgaard, J
   Dorup, I
   Sorensen, K
   Nielsen, TT
TI Effect of oral nitroglycerin and cold stress on myocardial perfusion in
   areas subtended by stenosed and nonstenosed coronary arteries
SO AMERICAN JOURNAL OF CARDIOLOGY
LA English
DT Article
ID EMISSION COMPUTED-TOMOGRAPHY; BLOOD-FLOW; VASOMOTOR RESPONSE; N-13
   AMMONIA; SYNDROME-X; ENDOTHELIUM; QUANTIFICATION; QUANTITATION;
   STIMULATION; INFARCTION
AB Physical obstruction and coronary vasoconstriction mediated by adrenergic stress are believed to be responsible for episodes of myocardial hypoperfusion and angina. Nitroglycerin relieves symptoms by reducing preload and dilating epicardial vessels. The net perfusion change and relation to stenosis severity of nitroglycerin and adrenergic stress have been debated. This study aimed to evaluate whether oral nitroglycerin and adrenergic stress alters perfusion in myocardial segments subtended by stenosed and nonstenosed coronary arteries. Myocardial perfusion was quantified (using N-13-ammonia positron emission tomography [PET]) at rest, after oral nitroglycerin 400 mug, and after cold stress in 25 patients with coronary artery disease (62 +/- 9 years, 21 men) and in 30 controls (34 9 years, 22 men). Myocardial perfusion was quantified in areas supplied by stenosed (> 70%) and nonstenosed (< 30%) coronary arteries. The cold pressor test did not significantly alter myocardial perfusion in any of the groups. However, when normalized for rate-pressure product, the response in stenosed areas showed a significantly more pronounced reduction compared with nonstenosed areas (0.78 +/- 0.18 vs 0.64 +/- 0.19 ml/g/min, p < 0.005 and 0.86 +/- 0.19 vs 0.73 +/- 0.24 ml/g/min, p <0.05, p <0.05) for intergroup comparison. In both stenosed areas and nonstenosed areas nitroglycerin increased perfusion (0.51 +/- 0.14 vs 0.60 +/- 0.17 ml/g/min, p <0.05 and 0.56 +/- 0.14 vs 0.61 +/- 0.17 ml/g/min, P <0.05). Nitroglycerin did not alter myocardial perfusion in the control group. There was a negative correlation between the cold pressor test response and stenosis severity (r(2) = 0. 17, p <0.046), whereas this was not the case for nitroglycerin. In patients with coronary artery disease, myocardial segments supplied by stenosed coronary arteries showed an altered perfusion response to adrenergic stress. Oral nitroglycerin increased myocardial perfusion irrespective of the presence of a stenosis. (C) 2002 by Excerpta Medica, Inc.
C1 Aarhus Univ Hosp, SKS, Dept Cardiol B, DK-8200 Aarhus N, Denmark.
C3 Aarhus University
RP Bottcher, M (corresponding author), Aarhus Univ Hosp, SKS, Dept Cardiol B, DK-8200 Aarhus N, Denmark.
RI Bottcher, M./AAI-8098-2020
OI Bottcher, Morten/0000-0002-2116-2370
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NR 23
TC 21
Z9 54
U1 0
U2 0
PU EXCERPTA MEDICA INC
PI NEW YORK
PA 650 AVENUE OF THE AMERICAS, NEW YORK, NY 10011 USA
SN 0002-9149
J9 AM J CARDIOL
JI Am. J. Cardiol.
PD MAY 1
PY 2002
VL 89
IS 9
BP 1019
EP 1024
AR PII S0002-9149(02)02268-3
DI 10.1016/S0002-9149(02)02268-3
PG 6
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 548TU
UT WOS:000175406600002
PM 11988188
DA 2025-06-11
ER

PT J
AU Colle, R
   de Larminat, D
   Rotenberg, S
   Hozer, F
   Hardy, P
   Verstuyft, C
   Fève, B
   Corruble, E
AF Colle, Romain
   de larminat, Delphine
   Rotenberg, Samuel
   Hozer, Franz
   Hardy, Patrick
   Verstuyft, Celine
   Feve, Bruno
   Corruble, Emmanuelle
TI Pioglitazone could induce remission in major depression: a meta-analysis
SO NEUROPSYCHIATRIC DISEASE AND TREATMENT
LA English
DT Article
DE pioglitazone; major depressive episode; major depressive disorder;
   bipolar disorder; remission; meta-analysis
ID PPAR-GAMMA; METABOLIC SYNDROME; DOUBLE-BLIND; ADJUNCTIVE THERAPY;
   BIPOLAR DISORDER; RECEPTOR; OUTCOMES; INVOLVEMENT; MECHANISMS; CONSENSUS
AB Background: Pioglitazone, a selective agonist of the nuclear transcription factor peroxisome proliferator-activated receptor-gamma (PPAR-gamma), prescribed for the treatment of type 2 diabetes, could have antidepressant properties. However, its potential to induce remission of major depressive episodes, the optimal clinical target for an antidepressant drug, is a matter of concern. Indeed, only one out of four double-blind randomized controlled trials show higher remission rates with pioglitazone than with control treatments. Hence, the main aim of this study was to perform a meta-analysis of the efficacy of pioglitazone for the treatment of MDE, focusing on remission rates.
   Methods: Four double-blind randomized controlled trials, comprising 161 patients with an MDE, were included in this meta-analysis. Pioglitazone was studied either alone (one study) or as add-on therapy to conventional treatments (antidepressant drugs or lithium salts). It was compared either to placebo (three studies) or to metformin (one study). Remission was defined by a Hamilton Depression Rating Scale score <8 after treatment.
   Results: Pioglitazone could induce higher remission rates than control treatments (27% versus 10%, I-2= 17.3%, fixed-effect model: odds ratio [OR]=3.3, 95% confidence interval [95% CI; 1.4; 7.8], P=0.008). The OR was even higher in the subgroup of patients with major depressive disorder (n= 80; 23% versus 8%, I-2= 0.0%; fixed-effect model: OR=5.9, 95% CI [1.6; 22.4], P= 0.009) and in the subgroup of patients without metabolic comorbidities (n= 84; 33% versus 10%, I-2= 0.0%; fixed-effect model: OR=5.1, 95% CI [1.5; 17.9], P=0.01). As compared to control treatments, results suggest six patients would need to be treated with pioglitazone in order to achieve the possibility of one more remission.
   Conclusion: Pioglitazone, either alone or as add-on therapy to conventional treatments, could induce remission of MDE, suggesting that drugs with PPAR-gamma agonist properties may be true and clinically relevant antidepressants, even in patients without metabolic comorbidities.
C1 [Colle, Romain; de larminat, Delphine; Rotenberg, Samuel; Hozer, Franz; Hardy, Patrick; Corruble, Emmanuelle] Univ Paris Sud, Hop Bicetre, AP HP, Psychiatry Dept,INSERM,UMR S1178, 78 Rue Gen Leclerc, F-94275 Le Kremlin Bicetre, France.
   [Verstuyft, Celine] Univ Paris Sud, Hop Bicetre, AP HP,INSERM UMR S1184, Mol Genet Pharmacogenet & Hormonol Dept,Ctr IMVA, Le Kremlin Bicetre, France.
   [Feve, Bruno] Univ Paris 06, Hop St Antoine, AP HP,Inst Hosp Univ ICAN,Sorbonne Univ, Endocrinol Dept,INSERM UMR S938,Ctr Rech St Antoi, Paris, France.
C3 Institut National de la Sante et de la Recherche Medicale (Inserm);
   Universite Paris Cite; Assistance Publique Hopitaux Paris (APHP);
   Hopital Universitaire Bicetre - APHP; Hopital Universitaire
   Antoine-Beclere - APHP; Universite Paris Saclay; Assistance Publique
   Hopitaux Paris (APHP); Hopital Universitaire Antoine-Beclere - APHP;
   Hopital Universitaire Bicetre - APHP; Universite Paris Saclay; Institut
   National de la Sante et de la Recherche Medicale (Inserm); Sorbonne
   Universite; Assistance Publique Hopitaux Paris (APHP); Hopital
   Universitaire Saint-Antoine - APHP
RP Colle, R (corresponding author), Univ Paris Sud, Hop Bicetre, AP HP, Psychiatry Dept,INSERM,UMR S1178, 78 Rue Gen Leclerc, F-94275 Le Kremlin Bicetre, France.
EM romaincolle@hotmail.com
RI verstuyft, celine/AAU-3343-2021; Colle, romain/D-9144-2017
OI Feve, Bruno/0000-0001-6577-9009; verstuyft, celine/0000-0002-8534-224X;
   Hozer, Franz/0000-0003-4592-0532; Colle, Romain/0000-0002-2549-4495
FU AstraZeneca; Sanofi; Novo Nordisk; MSD; ViiV Healthcare; Janssen
FX Romain Colle, Delphine de Larminat, Samuel Rotenberg, Franz Hozer,
   Patrick Hardy, Celine Verstuyft, and Emmanuelle Corruble report no
   conflicts of interest in this work. Bruno Feve has received conference
   fees from AstraZeneca, Sanofi, Novo Nordisk and MSD, consulting fees
   from Sanofi, and grants from ViiV Healthcare, Janssen, and MSD. The
   authors report no other conflicts of interest in this work.
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NR 42
TC 56
Z9 59
U1 0
U2 17
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
EI 1178-2021
J9 NEUROPSYCH DIS TREAT
JI Neuropsychiatr. Dis. Treat.
PY 2017
VL 13
BP 9
EP 16
DI 10.2147/NDT.S121149
PG 8
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA EF5NO
UT WOS:000390377100002
PM 28031713
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Hamieh, N
   Airagnes, G
   Descatha, A
   Goldberg, M
   Limosin, F
   Roquelaure, Y
   Lemogne, C
   Zins, M
   Matta, J
AF Hamieh, Nadine
   Airagnes, Guillaume
   Descatha, Alexis
   Goldberg, Marcel
   Limosin, Frederic
   Roquelaure, Yves
   Lemogne, Cedric
   Zins, Marie
   Matta, Joane
TI Atypical working hours are associated with tobacco, cannabis and alcohol
   use: longitudinal analyses from the CONSTANCES cohort
SO BMC PUBLIC HEALTH
LA English
DT Article
DE Addictology; Long working hours; Night shifts; Non-fixed working hours;
   Occupational health; Public health; Substance use; Workplace
ID POPULATION-BASED COHORT; METABOLIC SYNDROME; FAMILY CONFLICT; SHIFT
   WORK; DRUG-USE; HEALTH; RISK; DEPRESSION; METAANALYSIS; CONSUMPTION
AB Background This study examined prospective associations between atypical working hours with subsequent tobacco, cannabis and alcohol use as well as sugar and fat consumption. Methods In the French population-based CONSTANCES cohort, 47,288 men and 53,324 women currently employed included between 2012 and 2017 were annually followed for tobacco and cannabis use. Among them, 35,647 men and 39,767 women included between 2012 and 2016 were also followed for alcohol and sugar and fat consumption. Three indicators of atypical working hours were self-reported at baseline: working at night, weekend work and non-fixed working hours. Generalized linear models computed odds of substance use and sugar and fat consumption at follow-up according to atypical working hours at baseline while adjusting for sociodemographic factors, depression and baseline substance use when appropriate. Results Working at night was associated with decreased smoking cessation and increased relapse in women [odds ratios (ORs) of 0.81 and 1.25], increased cannabis use in men [ORs from 1.46 to 1.54] and increased alcohol use [ORs from 1.12 to 1.14] in both men and women. Weekend work was associated with decreased smoking cessation in women [ORs from 0.89 to 0.90] and increased alcohol use in both men and women [ORs from 1.09 to 1.14]. Non-fixed hours were associated with decreased smoking cessation in women and increased relapse in men [ORs of 0.89 and 1.13] and increased alcohol use in both men and women [ORs from 1.12 to 1.19]. Overall, atypical working hours were associated with decreased sugar and fat consumption. Conclusions The potential role of atypical working hours on substance use should be considered by public health policy makers and clinicians in information and prevention strategies.
C1 [Hamieh, Nadine; Airagnes, Guillaume; Goldberg, Marcel; Zins, Marie; Matta, Joane] INSERM, Populat Based Epidemiol Cohorts Unit, UMS 011, Villejuif, France.
   [Airagnes, Guillaume; Goldberg, Marcel; Zins, Marie] Univ Paris Cite, Fac Hlth, Sch Med, F-75006 Paris, France.
   [Airagnes, Guillaume] Ctr Univ Paris, Hop Europeen Georges Pompidou, AP HP, Ctr Ambulatoire Addictol,DMU Psych & Addictol, F-75015 Paris, France.
   [Descatha, Alexis] Acad Hosp CHU Angers, Poison Control Ctr, F-49000 Angers, France.
   [Descatha, Alexis; Roquelaure, Yves] Univ Angers, Univ Rennes,UMR S 1085, Ctr Hosp Univ CHU Angers,Ecole Hautes Etud Sante, Inst Rech Sante Environm & Travail Irset,INSERM, F-49000 Angers, France.
   [Descatha, Alexis] Donald & Barbara Zucker Sch Med Hofstra Northwell, Dept Occupat Med Epidemiol & Prevent, Hempstead, NY USA.
   [Limosin, Frederic; Lemogne, Cedric] Univ Paris Cite, Inst Psychiat & Neurosci Paris, INSERM U1266, F-75014 Paris, France.
   [Limosin, Frederic] Ctr Univ Paris, Hop Corentin Celton, AP HP, DMU Psychiat & Addictol,Serv Psychiat & Addictol, F-912130 Issy Les Moulineaux, France.
   [Roquelaure, Yves] Univ Angers, Univ Rennes, Ctr Hosp Univ Angers, Ctr Consultat Pathol Profess & Sante Travail, F-49000 Angers, France.
   [Lemogne, Cedric] Ctr Univ Paris, Hop Hotel Dieu, AP HP, DMU Psychiat & Addictol,Serv Psychiat Adulte, F-75004 Paris, France.
C3 Institut National de la Sante et de la Recherche Medicale (Inserm);
   Universite Paris Cite; Universite Paris Cite; Assistance Publique
   Hopitaux Paris (APHP); Universite Paris Cite; Hopital Universitaire
   Europeen Georges-Pompidou - APHP; Universite d'Angers; Centre
   Hospitalier Universitaire d'Angers; Institut National de la Sante et de
   la Recherche Medicale (Inserm); Northwell Health; Universite Paris Cite;
   Institut National de la Sante et de la Recherche Medicale (Inserm);
   Assistance Publique Hopitaux Paris (APHP); Universite Paris Cite;
   Hopital Universitaire Corentin-Celton - APHP; Universite d'Angers;
   Centre Hospitalier Universitaire d'Angers; Assistance Publique Hopitaux
   Paris (APHP); Universite Paris Cite; Hopital Universitaire Hotel-Dieu -
   APHP
RP Airagnes, G (corresponding author), INSERM, Populat Based Epidemiol Cohorts Unit, UMS 011, Villejuif, France.; Airagnes, G (corresponding author), Univ Paris Cite, Fac Hlth, Sch Med, F-75006 Paris, France.; Airagnes, G (corresponding author), Ctr Univ Paris, Hop Europeen Georges Pompidou, AP HP, Ctr Ambulatoire Addictol,DMU Psych & Addictol, F-75015 Paris, France.
EM guillaume.airagnes@aphp.fr
RI Goldberg, Marcel/I-7834-2012; Roquelaure, Yves/J-8208-2015; Hamieh,
   Nadine/AAH-9856-2020; Airagnes, Guillaume/M-8309-2017; Zins,
   Marie/AAX-6551-2021; Lemogne, Cédric/Q-6091-2019
OI Hamieh, Nadine/0000-0003-0770-4185
FU French Interministerial Mission for Combating Drugs and Addictive
   Behaviours (MILDECA); French National Health Insurance Fund ("Caisse
   nationale d'assurance maladie", CNAM); French National Agency for
   Research [ANR-11-INBS-0002]; Merck Sharp Dohme (MSD); AstraZeneca;
   Lundbeck; L'Oreal through Inserm-Transfert
FX NH was supported by a grant from the French Interministerial Mission for
   Combating Drugs and Addictive Behaviours (MILDECA). The CONSTANCES
   Cohort Study was supported and funded by the French National Health
   Insurance Fund ("Caisse nationale d'assurance maladie", CNAM). The
   CONSTANCES Cohort Study is an "Infrastructure nationale en Biologie et
   Sante" and benefits from a grant from the French National Agency for
   Research (ANR-11-INBS-0002). CONSTANCES is also partly funded by Merck
   Sharp & Dohme (MSD), AstraZeneca, Lundbeck and L'Oreal through
   Inserm-Transfert. None of these funding sources had any role in the
   design of the study, collection and analysis of data or decision to
   publish.
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NR 66
TC 4
Z9 5
U1 0
U2 4
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2458
J9 BMC PUBLIC HEALTH
JI BMC Public Health
PD SEP 29
PY 2022
VL 22
IS 1
AR 1834
DI 10.1186/s12889-022-14246-x
PG 17
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA 4Z0HB
UT WOS:000861899400003
PM 36175874
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Habibullah, M
   Jemmieh, K
   Ouda, A
   Haider, MZ
   Malki, MI
   Elzouki, AN
AF Habibullah, Mohammad
   Jemmieh, Khaleed
   Ouda, Amr
   Haider, Mohammad Zulqurnain
   Malki, Mohammed Imad
   Elzouki, Abdel-Naser
TI Metabolic-associated fatty liver disease: a selective review of
   pathogenesis, diagnostic approaches, and therapeutic strategies
SO FRONTIERS IN MEDICINE
LA English
DT Review
DE metabolic associated fatty liver disease (MAFLD); non-alcoholic fatty
   liver disease (NAFLD); diagnostic criteria; hepatic steatosis;
   nonalcoholic steatohepatitis (NASH); epidemiology; clinical
   manifestations; pathogenesis
ID ENDOPLASMIC-RETICULUM STRESS; INSULIN ACTION; HEPATIC STEATOSIS;
   UNITED-STATES; VITAMIN-D; FRUCTOSE; DIET; STEATOHEPATITIS; PREVALENCE;
   RESISTANCE
AB Background Metabolic associated fatty liver disease (MAFLD) is a novel terminology introduced in 2020 to provide a more accurate description of fatty liver disease associated with metabolic dysfunction. It replaces the outdated term nonalcoholic fatty liver disease (NAFLD) and aims to improve diagnostic criteria and tailored treatment strategies for the disease. NAFLD, the most prevalent liver disease in western industrialized nations, has been steadily increasing in prevalence and is associated with serious complications such as cirrhosis and hepatocellular carcinoma. It is also linked to insulin resistance syndrome and cardiovascular diseases. However, current studies on NAFLD have limitations in meeting necessary histological endpoints.Objective This literature review aims to consolidate recent knowledge and discoveries concerning MAFLD, integrating the diverse aspects of the disease. Specifically, it focuses on analyzing the diagnostic criteria for MAFLD, differentiating it from NAFLD and alcoholic fatty liver disease (AFLD), and exploring the epidemiology, clinical manifestations, pathogenesis, and management approaches associated with MAFLD. The review also explores the associations between MAFLD and other conditions. It discusses the heightened mortality risk associated with MAFLD and its link to chronic kidney disease (CKD), showing that MAFLD exhibits enhanced diagnostic accuracy for identifying patients with CKD compared to NAFLD. The association between MAFLD and incident/prevalent CKD is supported by cohort studies and meta-analyses.Conclusion This literature review highlights the importance of MAFLD as a distinct terminology for fatty liver disease associated with metabolic dysfunction. The review provides insights into the diagnostic criteria, associations with CKD, and management approaches for MAFLD. Further research is needed to develop more accurate diagnostic tools for advanced fibrosis in MAFLD and to explore the underlying mechanisms linking MAFLD with other conditions. This review serves as a valuable resource for researchers and healthcare professionals seeking a comprehensive understanding of MAFLD.
C1 [Habibullah, Mohammad; Jemmieh, Khaleed; Ouda, Amr; Haider, Mohammad Zulqurnain; Malki, Mohammed Imad; Elzouki, Abdel-Naser] Qatar Univ, Coll Med, QU Hlth, Doha, Qatar.
   [Elzouki, Abdel-Naser] Hamad Gen Hosp, Internal Med Dept, Doha, Qatar.
   [Elzouki, Abdel-Naser] Weill Cornell Med Qatar, Doha, Qatar.
C3 Qatar University; Hamad Medical Corporation; Hamad General Hospital;
   Qatar Foundation (QF); Weill Cornell Medical College Qatar
RP Malki, MI; Elzouki, AN (corresponding author), Qatar Univ, Coll Med, QU Hlth, Doha, Qatar.; Elzouki, AN (corresponding author), Hamad Gen Hosp, Internal Med Dept, Doha, Qatar.; Elzouki, AN (corresponding author), Weill Cornell Med Qatar, Doha, Qatar.
EM momalki@qu.edu.qa; aelzouki@hamad.qa
RI Malki, Mohammed Imad/AFV-6020-2022
FU American Association for the Study of Liver Diseases10.13039/100005347
FX No Statement Available
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NR 126
TC 28
Z9 28
U1 36
U2 79
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 2296-858X
J9 FRONT MED-LAUSANNE
JI Front. Med.
PD JAN 23
PY 2024
VL 11
AR 1291501
DI 10.3389/fmed.2024.1291501
PG 14
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA GZ6A2
UT WOS:001156531100001
PM 38323033
OA gold
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Lee, SY
   Chen, SL
   Chang, YH
   Chen, PS
   Huang, SY
   Tzeng, NS
   Wang, YS
   Wang, LJ
   Lee, IH
   Wang, TY
   Yeh, TL
   Yang, YK
   Hong, JS
   Lu, RB
AF Lee, Sheng-Yu
   Chen, Shiou-Lan
   Chang, Yun-Hsuan
   Chen, Po See
   Huang, San-Yuan
   Tzeng, Nian-Sheng
   Wang, Yu-Shan
   Wang, Liang-Jen
   Lee, I. Hui
   Wang, Tzu-Yun
   Yeh, Tzung Lieh
   Yang, Yen Kuang
   Hong, Jau-Shyong
   Lu, Ru-Band
TI Inflammation's Association with Metabolic Profiles before and after a
   Twelve-Week Clinical Trial in Drug-Naive Patients with Bipolar II
   Disorder
SO PLOS ONE
LA English
DT Article
ID C-REACTIVE PROTEIN; TUMOR-NECROSIS-FACTOR; GROWTH-FACTOR-BETA;
   INSULIN-RESISTANCE; ADIPOSE-TISSUE; FACTOR-ALPHA; RATING-SCALE;
   DOUBLE-BLIND; OBESITY; DEPRESSION
AB Inflammation is thought to be involved in the pathophysiology of bipolar disorder (BP) and metabolic syndrome. Prior studies evaluated the association between metabolic profiles and cytokines only during certain mood states instead of their changes during treatment. We enrolled drug-naive patients with BP-II and investigated the correlation between changes in mood symptoms and metabolic indices with changes in plasma cytokine levels after 12 weeks of pharmacological treatment. Drug-naive patients (n = 117) diagnosed with BP-II according to DSM-IV criteria were recruited. Metabolic profiles (cholesterol, triglyceride, HbA1C, fasting serum glucose, body mass index (BMI) and plasma cytokines (TNF-alpha, CRP, IL-6, and TGF-beta) were measured at baseline and 2, 8, and 12 weeks post-treatment. To adjust within-subject dependence over repeated assessments, multiple linear regressions with generalized estimating equation methods were used. Seventy-six (65.0%) patients completed the intervention. Changes in plasma CRP were significantly associated with changes in BMI (P = 1.7E-7) and triglyceride (P = 0.005) levels. Changes in plasma TGF-beta 1 were significantly associated with changes in BMI (P = 8.2E-6), cholesterol (P = 0.004), and triglyceride (P = 0.006) levels. However, changes in plasma TNF-alpha and IL-6 were not associated with changes in any of the metabolic indices. Changes in Hamilton Depression Rating Scale scores were significantly associated with changes in IL-6 (P = 0.003) levels; changes in Young Mania Rating Scale scores were significantly associated with changes in CRP (P = 0.006) and TNF-alpha (P = 0.039) levels. Plasma CRP and TGF-beta 1 levels were positively correlated with several metabolic indices in BP-II after 12 weeks of pharmacological intervention. We also hypothesize that clinical symptoms are correlated with certain cytokines. These new findings might be important evidence that inflammation is the pathophysiology of clinical symptoms and metabolic disturbance in BP-II.
C1 [Lee, Sheng-Yu; Chen, Shiou-Lan; Chen, Po See; Lee, I. Hui; Yeh, Tzung Lieh; Yang, Yen Kuang; Lu, Ru-Band] Natl Cheng Kung Univ, Dept Psychiat, Tainan 70101, Taiwan.
   [Chen, Shiou-Lan; Wang, Yu-Shan; Lu, Ru-Band] Natl Cheng Kung Univ, Inst Behav Med, Tainan 70101, Taiwan.
   [Chang, Yun-Hsuan; Lu, Ru-Band] Natl Cheng Kung Univ, Coll Med & Hosp, Inst Allied Hlth Sci, Tainan 70101, Taiwan.
   [Huang, San-Yuan; Tzeng, Nian-Sheng] Triserv Gen Hosp, Natl Def Med Ctr, Dept Psychiat, Taipei, Taiwan.
   [Wang, Liang-Jen] Kaohsiung Chang Gung Mem Hosp, Dept Child & Adolescent Psychiat, Kaohsiung, Taiwan.
   [Wang, Liang-Jen] Chang Gung Univ, Coll Med, Kaohsiung, Taiwan.
   [Lu, Ru-Band] Natl Cheng Kung Univ, Addict Res Ctr, Tainan 70101, Taiwan.
   [Wang, Tzu-Yun] Tainan Hosp, Dept Hlth, Dept Psychiat, Tainan, Taiwan.
   [Hong, Jau-Shyong] NIEHS, Lab Toxicol & Pharmacol, NIH, Res Triangle Pk, NC 27709 USA.
C3 National Cheng Kung University; National Cheng Kung University; National
   Cheng Kung University; Tri-Service General Hospital; National Defense
   Medical Center; Chang Gung Memorial Hospital; Chang Gung University;
   National Cheng Kung University; National Institutes of Health (NIH) -
   USA; NIH National Institute of Environmental Health Sciences (NIEHS)
RP Lu, RB (corresponding author), Natl Cheng Kung Univ, Dept Psychiat, Tainan 70101, Taiwan.
EM rblu@mail.ncku.edu.tw
RI Wang, Liang-Jen/AAR-1089-2020; Chen, Han-Shen/E-5881-2018; Chen,
   Shih-Heng/J-6429-2015; Chen, Po/AAA-6492-2021; Chang, Hui/AGD-4270-2022;
   Tzeng, Nian-Sheng/AAU-4945-2021; Hong, Jau-Shyong/F-1920-2019
OI Chang, Yun-Hsuan/0000-0001-8662-2457; Wang,
   Liang-Jen/0000-0002-5320-1151; Chen, Shiou Lan/0000-0003-3995-0276;
   Hong, Jau-Shyong/0000-0002-3056-8401
FU Taiwan National Science Council [NSC98-2314-B-006-022-MY3]; Taiwan
   Department of Health [DOH 95-TD-M-113-055]; Taiwan National Health
   Research Institute [NHRI-EX-97-9738NI]; National Cheng Kung University
   Project for Promoting Academic Excellence and Developing World Class
   Research Centers
FX This work was supported in part by grant NSC98-2314-B-006-022-MY3 (to
   RBL) and NSC98-2314-B-006-022-MY3 (to SYL) from the Taiwan National
   Science Council, grant DOH 95-TD-M-113-055 (to RBL) from the Taiwan
   Department of Health, grant NHRI-EX-97-9738NI (to RBL) from the Taiwan
   National Health Research Institute, and the National Cheng Kung
   University Project for Promoting Academic Excellence and Developing
   World Class Research Centers. The funders had no role in study design,
   data collection and analysis, decision to publish, or preparation of the
   manuscript.
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NR 75
TC 35
Z9 36
U1 0
U2 10
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
EI 1932-6203
J9 PLOS ONE
JI PLoS One
PD JUN 27
PY 2013
VL 8
IS 6
AR e66847
DI 10.1371/journal.pone.0066847
PG 7
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 174IX
UT WOS:000321150000016
PM 23826157
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Aldhoon, B
   Zamrazilová, H
   Hainerová, IA
   Srámková, P
   Spálová, J
   Kunesová, M
   Bendlová, B
   Hainer, V
AF Aldhoon, B.
   Zamrazilova, H.
   Hainerova, I. Aldhoon
   Sramkova, P.
   Spalova, J.
   Kunesova, M.
   Bendlova, B.
   Hainer, V.
TI Role of the PPARα Leu162Val and PPARγ2 Pro12Ala Gene
   Polymorphisms in Weight Change after 2.5-Year Follow-up in Czech Obese
   Women
SO FOLIA BIOLOGICA
LA English
DT Article
DE PPAR gamma 2; Pro12Ala polymorphism; obesity; PPAR alpha; Leu162Val
   polymorphism; body mass index changes; psycho-behavioural factors and
   genetics
ID BODY-MASS INDEX; ACTIVATED RECEPTOR-GAMMA-2 GENE; TYPE-2
   DIABETES-MELLITUS; METABOLIC SYNDROME; DIETARY RESTRAINT;
   GLUCOCORTICOID-RECEPTOR; EATING QUESTIONNAIRE; L162V POLYMORPHISM;
   INSULIN-RESISTANCE; GAMMA GENE
AB The aim of this study was to investigate the possible effect of PPAR alpha and PPAR gamma 2 variants on weight and eating attitudes as well as on their changes after 2.5-year follow-up. The study was carried out in 246 Czech non-diabetic obese women (age 49.0 +/- 11.9 years; BMI 38.1 +/- 7.0 kg/m(2)). The comprehensive weight management programme included low-energy diet, increased physical activity and lifestyle modification. Anthropometric parameters (body weight and height, waist and hip circumferences) and body composition were measured. The Three-Factor Eating Questionnaire and Beck Depression Inventory were evaluated. At baseline and after the follow-up period, fasting levels of serum glucose, plasma adiponectin, ghrelin, leptin, and lipid profile were determined. The dependence of monitored parameters on the Pro12Ala in PPAR gamma 2 and Leu162Val in PPARa and stage of the treatment (baseline; 2.5-year follow-up) was evaluated using the repeated measures ANOVA model. The cohort was re-examined after 2.5 years, independent of regular checkups and adherence to lifestyle recommendation. Significant favourable changes in anthropometric indexes, lipid profile, leptin, ghrelin and adiponectin levels as well as in dietary restraint and hunger scores were revealed at 2.5-year check-up. However, no changes in the scores of disinhibition and depression were demonstrated. Despite several observed significant differences between carriers and non-carriers of the minor alleles at baseline and at the follow-up, the repeated measures ANOVA did not reveal any significant effect of the PPAR alpha and PPAR gamma 2 polymorphisms on anthropometric, biochemical, hormonal and psycho-behavioural characteristics, neither at baseline nor at the 2.5-year follow-up.
C1 [Aldhoon, B.] Inst Clin & Expt Med, Dept Cardiol, Videnska 1958-9, Prague 14021 4, Czech Republic.
   [Aldhoon, B.; Zamrazilova, H.; Sramkova, P.; Spalova, J.; Kunesova, M.; Bendlova, B.; Hainer, V.] Inst Endocrinol, Prague, Czech Republic.
   [Hainerova, I. Aldhoon] Charles Univ Prague, Fac Med 3, Dept Pediat, Prague, Czech Republic.
   [Hainerova, I. Aldhoon] Ctr Res Diabet Metab & Nutr, Prague, Czech Republic.
   [Sramkova, P.] Clin Ctr ISCARE IVF, Obes Management Unit, Prague, Czech Republic.
C3 Institute for Clinical & Experimental Medicine (IKEM); Institute of
   Endocrinology - Prague; Charles University Prague
RP Aldhoon, B (corresponding author), Inst Clin & Expt Med, Dept Cardiol, Videnska 1958-9, Prague 14021 4, Czech Republic.
EM aldhoon@gmail.com
OI Aldhoon, Bashar/0000-0002-1845-847X
FU IGA MR CR [NR/7800-4, NS110209-3]; MSM [0021620814]; Danone Institute
FX The study was supported by grants from the research project of IGA MR CR
   NR/7800-4, IGA MH CR NS110209-3, MSM No. 0021620814 and the Danone
   Institute 2008/2009.
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NR 52
TC 11
Z9 11
U1 0
U2 13
PU CHARLES UNIV PRAGUE, FIRST FACULTY MEDICINE
PI PRAGUE 6
PA FLEMINGOVO NAM. 2, PRAGUE 6 166 37, CZECH REPUBLIC
SN 0015-5500
J9 FOLIA BIOL-PRAGUE
JI Folia Biol.-Prague
PY 2010
VL 56
IS 3
BP 116
EP 123
PG 8
WC Biochemistry & Molecular Biology; Biology; Oncology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Oncology; Cell Biology
GA 620IV
UT WOS:000279493800004
PM 20653996
DA 2025-06-11
ER

PT J
AU Lindsay, AC
   Greaney, ML
   Wallington, SF
   Wright, JA
   Hunt, AT
AF Lindsay, Ana Cristina
   Greaney, Mary L.
   Wallington, Sherrie F.
   Wright, Julie A.
   Hunt, Anne T.
TI Depressive Symptoms and Length of US Residency Are Associated with
   Obesity among Low-Income Latina Mothers: A Cross-Sectional Analysis
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Article
DE depression; obesity; Latina; mothers; immigrant; low-income; United
   States; maternal health
ID BODY-MASS INDEX; HEALTH LITERACY; UNITED-STATES; ACCULTURATION SCALE;
   ETHNIC-DIFFERENCES; METABOLIC SYNDROME; PHYSICAL-ACTIVITY; ASIAN
   IMMIGRANTS; WEIGHT STATUS; WOMEN
AB Latinos are the largest minority population group in the United States (U.S.), and low-income Latina women are at elevated risk of depression and obesity. Thus, the prevention of these two problems is a pressing public health concern in this population. Both depressive symptoms and obesity are modifiable factors that can be addressed by culturally relevant interventions. However, the association between depressive symptoms and obesity in Latina immigrant women is not well understood. Therefore, this cross-sectional study examined the association between depressive symptoms and obesity among Latina women of childbearing age (15-44). Participants (n = 147) were low-income, predominantly immigrant Latina mothers enrolled in the Latina Mothers 0 Child Feeding Practices and Style Study. Women were eligible to participate if they self-identified as Latina; were enrolled in or eligible for the Special Supplemental Nutrition Program for Women, Infants and Children program; had a child between ages two and five years; and were living in the U.S. for at least one year, and residing in Rhode Island. Enrolled participants completed a survey in their language of preference (English or Spanish) administered by bilingual interviewers. About one-third (34%) of participants were classified as having obesity (BMI >= 30 kg/m(2)), 28.3% had elevated depressive symptoms (CES-D >= 16), and 70.1% were immigrants. Women with elevated depressive symptoms had increased odds of having obesity (odds ratio (OR) = 2.80, 95% confidence interval (CI): 1.24-6.33). Additionally, among immigrants, length of U.S. residency was associated with increased odds of obesity (OR = 1.05, 95% CI: 1.02-1.09). Findings underscore the need for screening and culturally relevant interventions designed to address both depressive symptoms and obesity among low-income Latina women of childbearing age. Furthermore, findings highlight the importance of taking into account the length of residency in the U.S. when designing interventions targeting Latina immigrants.
C1 [Lindsay, Ana Cristina; Wright, Julie A.] Univ Massachusetts, Dept Exercise & Hlth Sci, Coll Nursing & Hlth Sci, Boston, MA 02125 USA.
   [Lindsay, Ana Cristina] Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA.
   [Greaney, Mary L.] Univ Rhode Isl, Hlth Studies, Kingston, RI 02881 USA.
   [Greaney, Mary L.] Univ Rhode Isl, Dept Kinesiol, Kingston, RI 02881 USA.
   [Wallington, Sherrie F.] Georgetown Univ, Med Ctr, Lombardi Comprehens Canc Ctr, Washington, DC 20057 USA.
   [Hunt, Anne T.] Hunt Consultants Associates, Chapel Hill, NC 27517 USA.
C3 University of Massachusetts System; University of Massachusetts Boston;
   Harvard University; Harvard T.H. Chan School of Public Health;
   University of Rhode Island; University of Rhode Island; Georgetown
   University
RP Lindsay, AC (corresponding author), Univ Massachusetts, Dept Exercise & Hlth Sci, Coll Nursing & Hlth Sci, Boston, MA 02125 USA.; Lindsay, AC (corresponding author), Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA.
EM Ana.Lindsay@umb.edu; mgreaney@uri.edu; slw49@georgetown.edu;
   Julie.Wright@umb.edu; hunt@post.harvard.edu
RI Wright, Julie/AAA-5169-2022
OI Wallington, Sherrie Lee/0000-0002-0242-1365; Wright,
   Julie/0000-0002-5115-7011
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NR 71
TC 12
Z9 14
U1 0
U2 11
PU MDPI AG
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD AUG
PY 2017
VL 14
IS 8
AR 869
DI 10.3390/ijerph14080869
PG 13
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA FF1UL
UT WOS:000408684300039
PM 28767094
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Pinter, A
   Kokolakis, G
   Rech, J
   Biermann, MHC
   Häberle, BM
   Multmeier, J
   Reinhardt, M
AF Pinter, Andreas
   Kokolakis, Georgios
   Rech, Juergen
   Biermann, Mona H. C.
   Haeberle, Benjamin M.
   Multmeier, Jan
   Reinhardt, Maximilian
TI Hidradenitis Suppurativa and Concurrent Psoriasis: Comparison of
   Epidemiology, Comorbidity Profiles, and Risk Factors
SO DERMATOLOGY AND THERAPY
LA English
DT Article
DE Cardiovascular risk; Comorbidity; Epidemiology; Hidradenitis
   suppurativa; Psoriasis; Smoking
ID PREVALENCE; AGE; SMOKING; INFLAMMATION; DIAGNOSIS
AB Introduction Hidradenitis suppurativa (HS) is a chronic, debilitating, and inflammatory skin disease. The epidemiology of HS varies greatly, with an estimated prevalence ranging from 0.03% to 4% worldwide. Similar to psoriasis (PsO), HS also exhibits a systemic inflammatory nature with a spectrum of systemic comorbidities. A large health insurance claims (HICs) database is analyzed to determine the demography and epidemiology of HS, PsO, and HS with concurrent PsO (HS-PsO) patients. Furthermore, the comorbidity profiles, including the comorbidity risk of these patient populations, are analyzed. Methods This is a noninterventional retrospective analysis of anonymized HICs data using a subset of the Institute of Applied Health Research Berlin (InGef) database. The primary outcome is the prevalence and incidence of HS, PsO, and HS-PsO. Secondary outcomes include comorbidity profiles and a comorbidity risk analysis. Results The prevalence and incidence of HS were 0.0681% and 0.0101%, respectively. The prevalence of HS-PsO was 0.004% (6% of the total HS population). HS patients frequently suffered from arterial hypertension (45%), nicotine dependence (46%), obesity (41%), and depression (36%), which were more common in HS-PsO patients compared with HS alone. HS patients had an increased prevalence of metabolic, psychiatric, immune-mediated, and cardiovascular diseases, e.g., overweight/obesity [odds ratio (OR): 2.65, 95% confidence interval (CI) 2.37-2.96], depression (OR: 1.55, 95% CI 1.42-1.76), or seronegative rheumatoid arthritis (OR: 2.82, 95% CI 1.61-4.94) compared with the overall population. The increased risk of myocardial infarction in HS patients (OR: 4.1, 95% CI 3.5-4.8, adjusting for age/sex) was largely attributed to patient's current smoking status (OR: 1.1, 95% CI 0.8-1.5, adjusting for smoking/age/sex). Conclusions HS patients show a broad spectrum of inflammatory and metabolic syndrome-related comorbidities, with an increased risk by concurrent PsO. Important for clinical practice, the elevated cardiovascular risk of HS patients can be largely attributed to smoking.
C1 [Pinter, Andreas] Univ Hosp Frankfurt, Clin Dermatol Venereol & Allergol, Frankfurt, Germany.
   [Kokolakis, Georgios] Charite Univ Med Berlin, Clin Dermatol Venereol & Allergol, Psoriasis Res & Treatment Ctr, Berlin, Germany.
   [Kokolakis, Georgios] Charite Univ Med Berlin, Inst Med Immunol, Berlin, Germany.
   [Rech, Juergen] Univ Klinikum Erlangen, Dept Internal Med Rheumatol & Immunol, Erlangen, Germany.
   [Biermann, Mona H. C.; Haeberle, Benjamin M.] Novartis Pharma GmbH, Nurnberg, Germany.
   [Multmeier, Jan] Elsevier Hlth Analyt, Berlin, Germany.
   [Reinhardt, Maximilian] Novartis Pharma AG, Basel, Switzerland.
C3 Goethe University Frankfurt; Goethe University Frankfurt Hospital;
   Berlin Institute of Health; Free University of Berlin; Humboldt
   University of Berlin; Charite Universitatsmedizin Berlin; Berlin
   Institute of Health; Free University of Berlin; Humboldt University of
   Berlin; Charite Universitatsmedizin Berlin; University of Erlangen
   Nuremberg; Novartis; Novartis Germany; Reed Elsevier; Elsevier; Novartis
RP Pinter, A (corresponding author), Univ Hosp Frankfurt, Clin Dermatol Venereol & Allergol, Frankfurt, Germany.
EM andreas.pinter@kgu.de
RI Pinter, Andreas/AAA-1474-2020
OI Kokolakis, Georgios/0000-0002-8042-7885; Haberle,
   Benjamin/0000-0001-9403-0136; Biermann, Mona/0000-0003-0496-5988;
   Pinter, Andreas/0000-0002-1330-1502
FU Novartis Pharma GmbH, Nurnberg, Germany
FX This analysis and the journal's Rapid Service Fee were funded by
   Novartis Pharma GmbH, Nurnberg, Germany.
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NR 49
TC 14
Z9 13
U1 1
U2 3
PU ADIS INT LTD
PI NORTHCOTE
PA 5 THE WAREHOUSE WAY, NORTHCOTE 0627, AUCKLAND, NEW ZEALAND
SN 2193-8210
EI 2190-9172
J9 DERMATOLOGY THER
JI Dermatol. Ther.
PD AUG
PY 2020
VL 10
IS 4
BP 721
EP 734
DI 10.1007/s13555-020-00401-y
EA JUN 2020
PG 14
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA ML7CZ
UT WOS:000538003400001
PM 32500484
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Chang, HH
   Lee, IH
   Gean, PW
   Lee, SY
   Chi, MH
   Yang, YK
   Lu, RB
   Chen, PS
AF Chang, Hui Hua
   Lee, I. Hui
   Gean, Po Wu
   Lee, Sheng-Yu
   Chi, Mei Hung
   Yang, Yen Kuang
   Lu, Ru-Band
   Chen, Po See
TI Treatment response and cognitive impairment in major depression:
   Association with C-reactive protein
SO BRAIN BEHAVIOR AND IMMUNITY
LA English
DT Article
DE Major depressive disorder; Antidepressants; C-reactive protein;
   Cognitive function
ID PROINFLAMMATORY CYTOKINES; SOCIOECONOMIC-STATUS; ALZHEIMERS-DISEASE;
   ANTIDEPRESSANT USE; METABOLIC SYNDROME; NERVOUS-SYSTEM; DOUBLE-BLIND;
   INFLAMMATION; RISK; PERFORMANCE
AB Levels of inflammatory markers have been found to be significantly associated with major depressive disorder (MDD) and cognitive impairment. The aim of this study was to investigate whether the level of C-reactive protein (CRP) is correlated with depressive mood and cognitive impairment in MDD patients. In 149 subjects with MDD, the 21-item Hamilton Rating Scale for Depression (HAM-D), Continuous Performance Test (CPT), Finger-Tapping Test (FTT), and Wisconsin Card-Sorting Test (WCST) were administered before and after antidepressant treatment. Besides, the level of CRP was measured. After 6 weeks of treatment, the total HAM-D scores decreased significantly. In addition, the subjects' performance in the masked CPT and the WCST with completed categories significantly improved (p < 0.001 and p = 0.027, respectively) after the reliable change indices were corrected for practice effects. The CRP levels had increased significantly after six weeks of treatment after adjustment for age and gender (p < 0.001). In addition, the CRP levels remained significantly high after six weeks of treatment in patients with a higher baseline level (r = 0.657, p < 0.001). Although the association between baseline CRP level and HAM-D score was not significant, the baseline CRP level was significantly correlated with treatment response at week 2 (r = 0.327, p = 0.020). The baseline CRP level was also negatively correlated with performance in the FTT before treatment (r = 0.580, p = 0.006). Moreover, the baseline CRP level was significantly correlated with performance in the FTT (r = -0.501, p = 0.021) and WCST with completed categories (r = -0.521, p = 0.015) at week 6. The cognitive function of patients with high baseline CRP levels might remain impaired even if their mood symptoms improve after antidepressant treatment. Whether adjunctive anti-inflammatory medication may help to preserve cognitive function merits further investigation. (C) 2011 Elsevier Inc. All rights reserved.
C1 [Chen, Po See] Natl Cheng Kung Univ, Dept Psychiat, Coll Med, Tainan 70428, Taiwan.
   [Lee, I. Hui; Lee, Sheng-Yu; Yang, Yen Kuang; Lu, Ru-Band; Chen, Po See] Natl Cheng Kung Univ, Hosp Med, Coll Med, Tainan 70428, Taiwan.
   [Chang, Hui Hua] Natl Cheng Kung Univ, Inst Biopharmaceut Sci, Coll Med, Tainan 70428, Taiwan.
   [Gean, Po Wu] Natl Cheng Kung Univ, Dept Pharmacol, Coll Med, Tainan 70428, Taiwan.
   [Lu, Ru-Band] Natl Cheng Kung Univ, Inst Behav Med, Coll Med, Tainan 70428, Taiwan.
   [Chi, Mei Hung; Chen, Po See] Natl Cheng Kung Univ Hosp, Dept Psychiat, Dou Liou Branch, Yunlin, Taiwan.
C3 National Cheng Kung University; National Cheng Kung University; National
   Cheng Kung University; National Cheng Kung University; National Cheng
   Kung University; National Cheng Kung University; National Cheng Kung
   University Hospital
RP Chen, PS (corresponding author), Natl Cheng Kung Univ, Dept Psychiat, Coll Med, 138 Sheng Li Rd, Tainan 70428, Taiwan.
EM chenps@mail.ncku.edu.tw
RI Chang, Hui/AGD-4270-2022; Chen, Po/AAA-6492-2021
OI Chang, Hui Hua/0000-0001-7866-5481
FU Addition Research Center, NCKU in the Institute; National Cheng Kung
   University; Department of Health, Taiwan [DOH96-TD-D-113-041]; National
   Science Council, Taiwan [NSC-98-2627-B-006-016]
FX The authors would like to thank the anonymous reviewers for their
   constructive comments, which improved the content and presentation of
   this paper. This study was supported by grants from the Addition
   Research Center, NCKU in the Institute, National Cheng Kung University
   Project for Promoting Academic Excellence and Developing World Class
   Research Centers, the Department of Health, Taiwan (DOH96-TD-D-113-041),
   and the National Science Council, Taiwan (NSC-98-2627-B-006-016).
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NR 61
TC 109
Z9 112
U1 1
U2 15
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0889-1591
EI 1090-2139
J9 BRAIN BEHAV IMMUN
JI Brain Behav. Immun.
PD JAN
PY 2012
VL 26
IS 1
BP 90
EP 95
DI 10.1016/j.bbi.2011.07.239
PG 6
WC Immunology; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Neurosciences & Neurology; Psychiatry
GA 855AC
UT WOS:000297534900012
PM 21839826
DA 2025-06-11
ER

PT J
AU Brun, JF
AF Brun, JF
TI Exercise hemorheology as a three acts play with metabolic actors: Is it
   of clinical relevance?
SO CLINICAL HEMORHEOLOGY AND MICROCIRCULATION
LA English
DT Article; Proceedings Paper
CT 11th European Symposium on Clinical Hemorheology
CY SEP 19-22, 2000
CL ROUEN, FRANCE
DE blood viscosity; hematocrit; exercise; VO2max; training; overtraining;
   metabolic fitness; hemorheology; erythrocyte deformability; erythrocyte
   aggregation; blood lactate
ID INCREMENTAL TREADMILL EXERCISE; DEPENDENT DIABETES-MELLITUS;
   POSTPRANDIAL REACTIVE HYPOGLYCEMIA; BLOOD-CELL DEFORMABILITY; CORONARY
   HEART-DISEASE; PLASMA VISCOSITY; INSULIN SENSITIVITY; SUBMAXIMAL
   EXERCISE; RISK-FACTORS; ERYTHROCYTE DEFORMABILITY
AB Hemorheological effects of exercise are a triphasic phenomenon including: (a) short-term effects (hyperviscosity mostly due to fluid shifts and alterations of erythrocyte rigidity and aggregability); (b) middle-term effects (i.e., the reversal of acute effects due to plasma volume expansion (autohemodilution) that lowers both plasma viscosity and hematocrit; (c) long-term effects that further improve blood fluidity, parallel with the classical training-induced hormonal and metabolic alterations. Red cell rheology during these 3 stages is affected by white cells and oxidant stress. On the other hand, most metabolic and hormonal alterations play a role in exercise-induced hemorheological changes: among them, blood lactate appears to have opposite effects according to the training status, since it generally impairs erythrocyte fluidity while it improves it in some subgroups of highly trained athletes, a difference that could be related to membrane monocarboxylate transporter status. Body composition (mostly hydration status and the amount of fat mass) as well as its major hormonal regulating system (the growth-hormone-IGF-I axis) are both markedly modified by training and these modifications are correlated with hemorheology. Nutritional disturbances affecting caloric and proteic intake, lipids, iron, zinc, etc. also modulate the hemorheologic effects of exercise. The overtraining syndrome represents a situation of unbalance between body's possibilities, nutrition, and work load, and is associated with metabolic, hormonal, immunologic and hemorheologic disturbances. The clinical relevance of these data is underlined by studies showing that exercise training in patients suffering from metabolic and/or cardiovascular disorders (such as the insulin resistance syndrome) results in a parallel improvement of metabolism, risk factors, blood rheology and fitness. Hemorheological measurements require to be studied, at least as sensitive markers of training, and possibly as "true" risk factors highly sensitive to exercise intensification.
C1 CHU Lapeyronie, CERAMM, Serv Cent Physiol Clin, F-34295 Montpellier 5, France.
C3 Universite de Montpellier; CHU de Montpellier
RP CHU Lapeyronie, CERAMM, Serv Cent Physiol Clin, F-34295 Montpellier 5, France.
EM drjfbrun.@aol.com
OI Jean-Frederic, Brun/0000-0002-2025-6340
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NR 180
TC 60
Z9 64
U1 0
U2 4
PU IOS PRESS
PI AMSTERDAM
PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS
SN 1386-0291
EI 1875-8622
J9 CLIN HEMORHEOL MICRO
JI Clin. Hemorheol. Microcirc.
PY 2002
VL 26
IS 3
BP 155
EP 174
PG 20
WC Hematology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Hematology; Cardiovascular System & Cardiology
GA 567MZ
UT WOS:000176489700003
PM 12082247
DA 2025-06-11
ER

PT J
AU Shapiro, LR
   Kennedy, KG
   Dimick, MK
   Goldstein, BI
AF Shapiro, Lila R.
   Kennedy, Kody G.
   Dimick, Mikaela K.
   Goldstein, Benjamin, I
TI Elevated atherogenic lipid profile in youth with bipolar disorder during
   euthymia and hypomanic/mixed but not depressive states
SO JOURNAL OF PSYCHOSOMATIC RESEARCH
LA English
DT Article
DE Youth; Bipolar disorder; Hypomania; Depression; Lipids; Cholesterol;
   Triglycerides; Mixed mood; Adolescents
ID SCHOOL-AGE-CHILDREN; LOW-DENSITY-LIPOPROTEIN; METABOLIC SYNDROME;
   CARDIOVASCULAR RISK; CHOLESTEROL LEVELS; MANIC EPISODE; SERUM-LIPIDS;
   SCHIZOPHRENIA; METAANALYSIS; ADOLESCENTS
AB Objective: Abnormal blood lipid levels are common in individuals with bipolar disorder (BD). Previous studies have revealed lipid-mood associations in adults with BD, but no data on this relationship is available in youth populations. This cross-sectional study examined the associations of lipid levels with mood states and symptoms in a cohort of youth with BD.
   Methods: Participants were youth with BD and healthy controls (HCs) between the ages of 13-20 years. We compared the levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipo-protein cholesterol (HDL-C), triglycerides (TG), and TG/HDL-C ratio between 4 participant episode groups: BD-euthymic (n = 28), BD-depressed (n = 29) BD-hypomanic/mixed (n = 31), and HCs (n = 89). We also examined for dimensional associations of lipids with mania and depression scores in the overall BD group and within BD episode subgroups.
   Results: TG levels were significantly higher in the BD-euthymic group (p = 0.008, d = 0.59) and in the BD-mixed/ hypomanic group (p = 0.03, d = 0.44) compared to the HC group. TG/HDL-C ratio was also higher in the BD-euthymic group compared to the HC group (p = 0.01, d = 0.51). No dimensional associations were found be-tween lipids and mood symptom scores in the overall BD group. However, within the BD-mixed/hypomanic subgroup, higher mania scores were associated with higher TG (beta = 0.42, p = 0.04), TG/HDL-C ratio (beta = 0.59, p = 0.002), and lower HDL-C (beta = 0.56 p = 0.002).
   Conclusions: Youth with BD demonstrate atherogenic lipid profiles. Higher atherogenic lipids were associated with hypomanic but, contrasting adult BD studies, not depressive symptoms. Future prospective studies are warranted to evaluate the temporal association between lipids and mood among youth with BD.
C1 [Shapiro, Lila R.; Kennedy, Kody G.; Dimick, Mikaela K.; Goldstein, Benjamin, I] Ctr Addict & Mental Hlth, Ctr Youth Bipolar Disorder, Toronto, ON, Canada.
   [Shapiro, Lila R.; Kennedy, Kody G.; Dimick, Mikaela K.; Goldstein, Benjamin, I] Univ Toronto, Dept Pharmacol, Toronto, ON, Canada.
C3 University of Toronto; Centre for Addiction & Mental Health - Canada;
   University of Toronto
RP Goldstein, BI (corresponding author), Ctr Addict & Mental Hlth, Rm 4326,80 Workman Way, Toronto, ON M6J 1H4, Canada.
EM benjamin.goldstein@camh.ca
RI Goldstein, Benjamin/ADR-2374-2022; Kennedy, Kody/HHD-2111-2022
OI Kennedy, Kody/0000-0002-4510-188X
FU Canadian Institutes of Health Research [MOP-136947]; Heart and Stroke
   Foundation [G-17-0017597]
FX This study was funded by the Canadian Institutes of Health Research,
   (Grant number: MOP-136947) and the Heart and Stroke Foundation (Grant
   number: G-17-0017597). Dr. Goldstein also acknowledges his position as
   RBC Investments Chair in Children's Mental Health and Developmental
   Psychopathologyat CAMH, a joint Hospital-University Chair between the
   University ofToronto, CAMH, and the CAMH Foundation. The funding sources
   were not involved in study design and the conduct of the research.
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NR 67
TC 5
Z9 6
U1 2
U2 17
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-3999
EI 1879-1360
J9 J PSYCHOSOM RES
JI J. Psychosomat. Res.
PD MAY
PY 2022
VL 156
AR 110763
DI 10.1016/j.jpsychores.2022.110763
EA FEB 2022
PG 7
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 1D8HN
UT WOS:000794037200003
PM 35193092
OA hybrid
DA 2025-06-11
ER

PT J
AU Rivera, AS
   Akanbi, M
   O'Dwyer, LC
   McHugh, M
AF Rivera, Adovich S.
   Akanbi, Maxwell
   O'Dwyer, Linda C.
   McHugh, Megan
TI Shift work and long work hours and their association with chronic health
   conditions: A systematic review of systematic reviews with meta-analyses
SO PLOS ONE
LA English
DT Review
ID DOSE-RESPONSE RELATIONSHIP; CORONARY-HEART-DISEASE; BREAST-CANCER RISK;
   LOW-BIRTH-WEIGHT; NIGHT WORK; CARDIOVASCULAR-DISEASE; PREGNANCY
   OUTCOMES; UNPUBLISHED DATA; PROSTATE-CANCER; PREECLAMPSIA
AB Background
   Previous reviews have demonstrated that shift work and long work hours are associated with increased risk for chronic conditions. However, these reviews did not comprehensively assessed the body of evidence, and some were not conducted in a systematic manner. A better understanding of the health consequences of shift work and long work hours will aid in creating policy and practice recommendations. This review revisits the epidemiologic evidence on the association of shift work and long work hours with chronic conditions with particular emphasis on assessing the quality of the evidence.
   Methods and findings
   We conducted a systematic review of systematic reviews with meta-analyses (SR-MA) that assessed the link between shift work or long work hours and chronic conditions (PROSPERO CRD42019122084). We evaluated the risk of bias of each SR-MA using AMSTAR v2 and assessed the overall evidence for each condition using the GRADE approach. We included 48 reviews covering cancers, cardiovascular diseases, metabolic syndrome and related conditions, pregnancy complications, depression, hypertension, and injuries. On average, only 7 of 16 AMSTAR items were fulfilled. Few SR-MAs had a registered protocol and nearly all failed to conduct a comprehensive search. We found moderate grade evidence linking shift work to breast cancer and long work hours to stroke. We found low grade evidence linking both shift work and long work hours with low to moderate increase in risk for some pregnancy complications and cardiovascular diseases. Low grade evidence also link long work hours and depression.
   Conclusions
   Moderate grade evidence suggest that shift work and long work hours increase the risk of breast cancer and stroke, but the evidence is unclear on other chronic conditions. There is a need for high-quality studies to address this gap. Stakeholders should be made aware of these increased risks, and additional screening and prevention should be considered, particularly for workers susceptible to breast cancer and stroke.
C1 [Rivera, Adovich S.; Akanbi, Maxwell; O'Dwyer, Linda C.; McHugh, Megan] Northwestern Univ, Inst Publ Hlth & Med, Feinberg Sch Med, Chicago, IL 60611 USA.
   [O'Dwyer, Linda C.] Northwestern Univ, Feinberg Sch Med, Galter Hlth Sci Lib, Chicago, IL 60611 USA.
   [O'Dwyer, Linda C.] Northwestern Univ, Feinberg Sch Med, Learning Ctr, Chicago, IL 60611 USA.
   [McHugh, Megan] Northwestern Univ, Feinberg Sch Med, Dept Emergency Med, Chicago, IL 60611 USA.
C3 Northwestern University; Feinberg School of Medicine; Northwestern
   University; Feinberg School of Medicine; Northwestern University;
   Feinberg School of Medicine; Northwestern University; Feinberg School of
   Medicine
RP Rivera, AS (corresponding author), Northwestern Univ, Inst Publ Hlth & Med, Feinberg Sch Med, Chicago, IL 60611 USA.
EM adovichrivera2021@u.northwestern.edu
RI Rivera, Adovich/AAK-9850-2021
OI O'Dwyer, Linda/0000-0003-0400-778X
FU Robert Wood Johnson Foundation [7610]
FX This project is funded through the Robert Wood Johnson Foundation
   (https://www.rwjf.org/) (Grant Number 7610) awarded to MM. The funders
   had no role in study design, data collection and analysis, decision to
   publish, or preparation of the manuscript.
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NR 67
TC 123
Z9 133
U1 2
U2 31
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD APR 2
PY 2020
VL 15
IS 4
AR e0231037
DI 10.1371/journal.pone.0231037
PG 19
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA LR8KJ
UT WOS:000535945000084
PM 32240254
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Gorska-Ciebiada, M
   Saryusz-Wolska, M
   Borkowska, A
   Ciebiada, M
   Loba, J
AF Gorska-Ciebiada, Malgorzata
   Saryusz-Wolska, Malgorzata
   Borkowska, Anna
   Ciebiada, Maciej
   Loba, Jerzy
TI Serum Levels of Inflammatory Markers in Depressed Elderly Patients with
   Diabetes and Mild Cognitive Impairment
SO PLOS ONE
LA English
DT Article
ID C-REACTIVE PROTEIN; CORONARY-HEART-DISEASE; LATE-LIFE DEPRESSION;
   METABOLIC SYNDROME; SYMPTOMS; ASSOCIATION; CYTOKINES; DEMENTIA; ADULTS;
   RISK
AB Objective
   The aim of the study was to determine the serum levels of CRP, IL-6 and TNF-alpha in elderly diabetic patients with depressive syndrome alone or with coexisting mild cognitive impairment (MCI).
   Methods
   276 diabetics elders were screened for depressive symptoms (using Geriatric Depression Scale: GDS-30) and MCI (using the Montreal Cognitive Assessment: MoCA score). Data of HbA1c, blood lipids and inflammatory markers levels were collected.
   Results
   In all groups of patients levels of CRP, IL-6 and TNF-alpha were significantly higher as compared to controls. The highest level of inflammatory markers was detected in group with depressive mood and coexisting MCI, however IL-6 level didn't significantly differ as compared to MCI group. We founded correlations between all inflammatory markers in group of patients with depressive mood and in group of subjects with depressive symptoms and coexisting MCI. GDS-30 score was correlated with levels of inflammatory markers in group with depressive mood, and with levels of CRP and TNF-alpha in group with depressive mood and coexisting MCI. In the group with depressive mood and coexisting MCI we founded that MoCA score was negatively correlated with CRP and TNF-alpha levels; and HbA1c level was positively correlated with all inflammatory markers. The univariate logistic regression models revealed that variables which increased the likelihood of having been diagnosed with MCI in depressed patients were: higher levels of HbA1c, CRP, IL-6 and TNF-alpha, previous CVD or stroke, increased number of co-morbidities and microvascular complications, older age, less years of formal education. The multivariable model showed that previous CVD, higher HbA1c and IL-6 levels are significant factors.
   Conclusions
   We demonstrated that the presence of depressive syndrome is associated with higher levels of inflammatory markers in elderly patients with diabetes. The presence of MCI in these depressed subjects has additive effect on levels of inflammatory mediators.
C1 [Gorska-Ciebiada, Malgorzata; Saryusz-Wolska, Malgorzata; Borkowska, Anna; Loba, Jerzy] Med Univ Lodz, Dept Internal Med & Diabetol, Lodz, Poland.
   [Ciebiada, Maciej] Med Univ Lodz, Dept Gen & Oncol Pneumol, Lodz, Poland.
C3 Medical University Lodz; Medical University Lodz
RP Gorska-Ciebiada, M (corresponding author), Med Univ Lodz, Dept Internal Med & Diabetol, Lodz, Poland.
EM magoca@poczta.onet.pl
RI Borkowska, Alina/G-8816-2014; Ciebiada, Maciej/S-9324-2016;
   Gorska-Ciebiada, Malgorzata/S-9668-2016
OI Ciebiada, Maciej/0000-0003-3391-264X; Gorska-Ciebiada,
   Malgorzata/0000-0002-0065-4376; Borkowska, Anna/0000-0002-8971-9868
FU Medical University of Lodz [502-03/8-072-03/502-64-052]
FX This work was supported by nonprofit grant of Medical University of Lodz
   no 502-03/8-072-03/502-64-052. The funders had no role in study design,
   data collection and analysis, decision to publish, or preparation of the
   manuscript.
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NR 52
TC 61
Z9 69
U1 1
U2 16
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAR 20
PY 2015
VL 10
IS 3
AR e0120433
DI 10.1371/journal.pone.0120433
PG 17
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA CE8HY
UT WOS:000352083900033
PM 25793613
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Zhao, LL
   Tang, P
   Fan, HJ
   Hao, MR
   Yao, XH
   Li, WZ
   Liu, LW
   Liu, HZ
AF Zhao, Lili
   Tang, Pei
   Fan, Haojie
   Hao, Mingru
   Yao, Xianhu
   Li, Wenzheng
   Liu, Lewei
   Liu, Huanzhong
TI Associations of leptin levels with psychopathology, BDNF and
   inflammatory cytokines in patients with chronic schizophrenia as well as
   gender differences
SO BMC PSYCHIATRY
LA English
DT Article
DE Chronic schizophrenia; Leptin; BDNF; Inflammatory cytokines; Gender
   differences
ID SERUM LEPTIN; DEPRESSION; DISORDER; HEALTH; SCALE
AB Background Metabolic syndrome significantly contributes to mortality among individuals suffering from chronic schizophrenia (CS), and there is a strong correlation between this condition and plasma leptin (LEP) levels. However, there are relatively few studies on the factors affecting leptin levels in chronic schizophrenia, and findings are often inconsistent. The purpose of this study was to investigate the leptin levels and their association with psychopathology, BDNF and inflammatory cytokines in patients with chronic schizophrenia, as well as potential gender differences. Methods The study enrolled 301 individuals diagnosed with chronic schizophrenia. Participants were assessed for psychotic symptoms, insomnia severity, and depressive symptoms using the Positive and Negative Syndrome Scale (PANSS), Insomnia Severity Index (ISI), and Calgary Depression Scale for Schizophrenia (CDSS), respectively. Leptin, BDNF and inflammatory cytokines levels were also detected. Results Among the patients, Log LEP levels were positively correlated with females, body mass index (BMI), systolic and diastolic blood pressures, Log BDNF, Log IL-6, and Log IL-17 A levels, and negatively correlated with the total score on the PANSS, as well as scores on the positive, negative, and general psychopathology subscales (all p < 0.05). Multiple linear regression analyses revealed that Log LEP levels were independently correlated with gender (beta = 0.514, t = 15.601, p < 0.001), BMI (beta = 0.053, t = 12.096, p < 0.001), diastolic blood pressure (beta = 0.005, t = 2.334, p = 0.020), and Log IL-17 A levels (beta = 0.062, t = 2.097, p = 0.037). Notably, these associations between leptin and the above factors were only observed in the male patients. Conclusions A significant link was identified between leptin levels and the presence of psychotic symptoms, BDNF, and inflammatory cytokines (especially IL-6 and IL-17 A) in individuals suffering from chronic schizophrenia, with notable variations observed between genders. Future research, including more longitudinal studies and animal models, is necessary to delve deeper into these associations and uncover their underlying mechanisms.
C1 [Zhao, Lili; Tang, Pei; Fan, Haojie; Hao, Mingru; Liu, Lewei; Liu, Huanzhong] Anhui Med Univ, Chaohu Hosp, Dept Psychiat, Hefei, Anhui, Peoples R China.
   [Li, Wenzheng] Anhui Med Univ, Affiliated Psychol Hosp, Hefei, Anhui, Peoples R China.
   [Yao, Xianhu] Maanshan Fourth Peoples Hosp, Dept Psychiat, Maanshan, Anhui, Peoples R China.
C3 Anhui Medical University; Anhui Medical University
RP Liu, LW; Liu, HZ (corresponding author), Anhui Med Univ, Chaohu Hosp, Dept Psychiat, Hefei, Anhui, Peoples R China.
EM liulewei0301@126.com; huanzhongliu@ahmu.edu.cn
RI Liu, Huan Zhong/T-5968-2018
FU National Key Clinical Specialty Project Foundation (CN)
FX We sincerely thank all the study participants.
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NR 62
TC 0
Z9 0
U1 0
U2 0
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-244X
J9 BMC PSYCHIATRY
JI BMC Psychiatry
PD MAY 22
PY 2025
VL 25
IS 1
AR 518
DI 10.1186/s12888-025-06974-2
PG 12
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychiatry
GA 2XW4P
UT WOS:001493915600001
PM 40405119
DA 2025-06-11
ER

PT J
AU Lanza, GA
   Buffon, A
   Sestito, A
   Natale, L
   Sgueglia, GA
   Galiuto, L
   Infusino, F
   Mariani, L
   Centola, A
   Crea, F
AF Lanza, Gaetano A.
   Buffon, Antonino
   Sestito, Alfonso
   Natale, Luigi
   Sgueglia, Gregory A.
   Galiuto, Leda
   Infusino, Fabio
   Mariani, Luca
   Centola, Antonio
   Crea, Filippo
TI Relation between stress-induced myocardial perfusion defects on
   cardiovascular magnetic resonance and coronary microvascular dysfunction
   in patients with cardiac syndrome X
SO JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
LA English
DT Article
ID ANGINA-PECTORIS; CHEST-PAIN; FLOW RESERVE; ANGIOGRAMS; ARTERIES;
   ISCHEMIA; ECHOCARDIOGRAPHY; REPERFUSION; SENSITIVITY
AB Objectives: The purpose of this study was to investigate whether a direct relation can be demonstrated between myocardial perfusion defects detected during dobutamine stress test (DST) by cardiovascular magnetic resonance (CMR) and impairment of coronary microvascular dilatory function in patients with cardiac syndrome X (CSX).
   Background: Despite the fact that coronary microvascular dysfunction has been shown in most patients with CSX, the ischemic origin of CSX remains debated. No previous study assessed whether a strict relation exists between abnormalities in myocardial perfusion and coronary microvascular dysfunction in CSX patients.
   Methods: Eighteen CSX patients (mean age 58 +/- 7 years, 7 men) and 10 healthy control subjects (mean age 54 +/- 8 years, 4 men) underwent myocardial perfusion study by gadolinium-enhanced CMR at rest and at peak DST (maximal dose 40 mu g/kg/min). Coronary flow response (CFR) to adenosine (140 mu g/kg/min in 90 s) in the left anterior descending (LAD) coronary artery was assessed by high-resolution transthoracic echo-Doppler and expressed as the ratio between coronary flow velocity at peak adenosine and at rest.
   Results: At peak DST, reversible perfusion defects on CMR were found in 10 CSX patients (56%) but in none of the control subjects (p = 0.004). The CFR to adenosine in the LAD coronary artery was lower in CSX patients than in control subjects (2.03 +/- 0.63 vs. 3.29 +/- 1.0, p = 0.0004). The CSX patients with DST-induced myocardial perfusion defects in the LAD territory on CMR had a lower CFR to adenosine compared with those without perfusion defects in the LAD territory (1.69 +/- 0.5 vs. 2.31 +/- 0.6, p = 0.01). A significant correlation was found in CSX patients between CFR to adenosine and a DST perfusion defect score on CMR in the LAD territory (r = -0.45, p = 0.019).
   Conclusions: Our data concurrently show DST-induced myocardial perfusion defects on CMR and reduced CFR in the LAD coronary artery territory in CSX patients, thus giving strong evidence that a dysfunction of coronary microcirculation resulting in myocardial perfusion abnormalities is present in these patients.
C1 [Lanza, Gaetano A.; Buffon, Antonino; Sestito, Alfonso; Sgueglia, Gregory A.; Galiuto, Leda; Infusino, Fabio; Mariani, Luca; Centola, Antonio; Crea, Filippo] Univ Cattolica Sacro Cuore, Ist Cardiol, I-00168 Rome, Italy.
   [Natale, Luigi] Univ Cattolica Sacro Cuore, Ist Radiol, I-00168 Rome, Italy.
C3 Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli;
   Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli
RP Lanza, GA (corresponding author), Univ Cattolica Sacro Cuore, Ist Cardiol, Largo A Gemelli 8, I-00168 Rome, Italy.
EM g.a.lanza@inwind.it
RI Lanza, Gaetano/AAC-2660-2019; Galiuto, Leonarda/AAB-9768-2022; Crea,
   Filippo/AAC-9754-2022; NATALE, Luigi/C-8234-2016; Sgueglia,
   Gregory/A-9701-2019; Infusino, Fabio/JEF-6750-2023
OI NATALE, Luigi/0000-0002-7949-5119; Sgueglia,
   Gregory/0000-0001-9680-7412; Buffon, Antonino/0000-0001-8144-6597;
   Infusino, Fabio/0000-0001-9287-5936
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NR 31
TC 142
Z9 150
U1 0
U2 3
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0735-1097
J9 J AM COLL CARDIOL
JI J. Am. Coll. Cardiol.
PD JAN 29
PY 2008
VL 51
IS 4
BP 466
EP 472
DI 10.1016/j.jacc.2007.08.060
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 255CA
UT WOS:000252633100008
PM 18222358
OA Bronze
DA 2025-06-11
ER

PT J
AU Mangge, H
   Stelzer, I
   Reininghaus, EZ
   Weghuber, D
   Postolache, TT
   Fuchs, D
AF Mangge, H.
   Stelzer, I.
   Reininghaus, E. Z.
   Weghuber, D.
   Postolache, T. T.
   Fuchs, D.
TI Disturbed Tryptophan Metabolism in Cardiovascular Disease
SO CURRENT MEDICINAL CHEMISTRY
LA English
DT Article
DE Anemia; cardiovascular disease; chronic immune activation syndrome; mood
   alteration; tryptophan breakdown
ID INDOLEAMINE 2,3-DIOXYGENASE ACTIVITY; IMPAIRED NOCTURNAL SYNTHESIS;
   ACUTE MYOCARDIAL-INFARCTION; BLOOD MONONUCLEAR-CELLS; INTERFERON-GAMMA;
   NEOPTERIN PRODUCTION; IMMUNE ACTIVATION; BIPOLAR DISORDER; OXIDATIVE
   STRESS; SERUM TRYPTOPHAN
AB Atherosclerosis (AS), a major pathologic consequence of obesity, is the main etiological factor of cardiovascular disease (CVD), which is the most common cause of death in the western world. A systemic chronic low grade immune-mediated inflammation (scLGI) is substantially implicated in AS and its consequences. In particular, pro-inflammatory cytokines play a major role, with Th1-type cytokine interferon-gamma (IFN-gamma) being a key mediator. Among various other molecular and cellular effects, IFN-gamma activates the enzyme indoleamine 2,3-dioxygenase (IDO) in monocyte-derived macrophages, dendritic, and other cells, which, in turn, decreases serum levels of the essential amino acid tryptophan (TRP). Thus, people with CVD often have increased serum kynurenine to tryptophan ratios (KYN/ TRP), a result of an increased TRP breakdown. Importantly, increased KYN/ TRP is associated with a higher likelihood of fatal cardiovascular events. A scLGI with increased production of the proinflammatory adipokine leptin, in combination with IFN-gamma and interleukin-6 (IL-6), represents another central link between obesity, AS, and CVD. Leptin has also been shown to contribute to Th1-type immunity shifting, with abdominal fat being thus a direct contributor to KYN/ TRP ratio. However, TRP is not only an important source for protein production but also for the generation of one of the most important neurotransmitters, 5-hydroxytryptamine (serotonin), by the tetrahydrobiopterin-dependent TRP 5-hydroxylase. In prolonged states of scLGI, availability of free serum TRP is strongly diminished, affecting serotonin synthesis, particularly in the brain. Additionally, accumulation of neurotoxic KYN metabolites such as quinolinic acid produced by microglia, can contribute to the development of depression via NMDA glutamatergic stimulation. Depression had been reported to be associated with CVD endpoints, but it most likely represents only a secondary loop connecting excess adipose tissue, scLGI and cardiovascular morbidity and mortality. Accelerated catabolism of TRP is further involved in the pathogenesis of the anemia of scLGI. The pro-inflammatory cytokine IFN-gamma suppresses growth and differentiation of erythroid progenitor cells, and the depletion of TRP limits protein synthesis and thus hemoglobin production, and, through reduction in oxygen supply, may contribute to ischemic vascular disease. In this review we discuss the impact of TRP breakdown and the related complex mechanisms on the prognosis and individual course of CVD. Measurement of TRP, KYN concentrations, and calculation of the KYN/ TRYP ratio will contribute to a better understanding of the interplay between inflammation, metabolic syndrome, mood disturbance, and anemia, all previously described as significant predictors of an unfavorable outcome in patients with CVD. The review leads to a novel framework for successful therapeutic modification of several cardinal pathophysiological processes leading to adverse cardiovascular outcome.
C1 [Mangge, H.; Stelzer, I.] Med Univ Graz, Clin Inst Med & Chem Lab Diagnost, A-8036 Graz, Austria.
   [Mangge, H.] BioTechMed Graz, Graz, Austria.
   [Reininghaus, E. Z.] Med Univ Graz, Dept Psychiat, A-8036 Graz, Austria.
   [Weghuber, D.] Paracelsus Private Med Sch Salzburg, Dept Pediat, Salzburg, Austria.
   [Postolache, T. T.] Univ Maryland, Sch Med, Dept Psychiat, Mood & Anxiety Program, Baltimore, MD 21201 USA.
   [Fuchs, D.] Med Univ Innsbruck, Bioctr, Div Biol Chem, A-6020 Innsbruck, Austria.
C3 Medical University of Graz; Medical University of Graz; Paracelsus
   Private Medical University; University System of Maryland; University of
   Maryland Baltimore; Medical University of Innsbruck
RP Mangge, H (corresponding author), Med Univ Graz, BioTechMed Graz, Clin Inst Med & Chem Lab Diagnost, Res Unit Lifestyle & Inflammation Associated Risk, Auenbruggerpl 30, A-8036 Graz, Austria.
EM harald.mangge@klinikum-graz.at
RI Weghuber, Daniel/AAN-1422-2020; Fuchs, Dietmar/AAL-8011-2021
OI Mangge, Harald/0000-0003-4067-247X; Reininghaus,
   Eva/0000-0001-5964-4087; Postolache, Teodor/0000-0001-6056-4244
FU european FP7 program "NanoAthero" [NMP4-LA-2012-3099820]
FX This work was supported by funding under the european FP7 program
   "NanoAthero" - NMP4-LA-2012-3099820. We want to thank further Dr.
   Florian Prueller, Clinical Institute of Medical and Chemical Laboratory
   Diagnostics, Graz, Austria for the expert technical assistance.
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NR 79
TC 93
Z9 96
U1 1
U2 40
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 0929-8673
EI 1875-533X
J9 CURR MED CHEM
JI Curr. Med. Chem.
PD JUN
PY 2014
VL 21
IS 17
BP 1931
EP 1937
DI 10.2174/0929867321666140304105526
PG 7
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Pharmacology &
   Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
GA AF3CY
UT WOS:000334590300002
PM 24606499
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Gould, KL
   Johnson, NP
AF Gould, K. Lance
   Johnson, Nils P.
TI Coronary Physiology Beyond Coronary Flow Reserve in Microvascular Angina
   JACC State-of-the-Art Review
SO JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
LA English
DT Review
DE microvascular angina; myocardial perfusion; positron emission
   tomography; small vessel disease; syndrome X
ID STRESS MYOCARDIAL-PERFUSION; CLINICAL-IMPLICATIONS; TRANSMURAL
   PERFUSION; ADENOSINE RECEPTOR; DISEASE; DYSFUNCTION; STENOSIS;
   MECHANISMS; ISCHEMIA; IMPACT
AB Angina with no angiographic stenosis, commonly called "microvascular angina," encompasses a wide continuum of coronary pathophysiology in conflicting published reports. Comprehensive quantitative myocardial perfusion offers new insights beyond overly simplistic coronary flow reserve. Integrating regional absolute stress flow, relative stress flow, coronary flow reserve, and qualitative subendocardial perfusion gradient on tomograms of relative images, provides correct diagnosis, quantitative physiological classification, and potential treatment. Angina without angiographic stenosis is associated with abnormal quantitative perfusion with rare, but instructive, exceptions. However, microvascular dysfunction without angina is common, particularly associated with risk factors. Reduced subendocardial/epicardial relative activity is common with diffuse coronary artery disease without focal stenosis with or without angina depending on the severity of reduced subendocardial perfusion. Precision quantitative myocardial perfusion in 5,900 cases objectively classifies angina with no angiographic stenosis into 4 categories: subendocardial ischemia due to diffuse coronary artery disease (most common), overlooked stenosis, diffuse microvascular dysfunction due to risk factors or specific microvasculopathies, and nonischemic cardiac pain mechanisms (rare), or some mix of these prototypes, of which 95% associate with risk factors, or subclinical or clinically manifest coronary atherosclerosis needing vigorous risk factor treatment. (c) 2018 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
C1 [Gould, K. Lance] UTHealth, McGovern Med Sch, Weatherhead PET Ctr, 6431 Fannin St,Room MSB 4-256, Houston, TX 77030 USA.
C3 Baylor College of Medicine; Baylor College Medical Hospital; University
   of Texas System; University of Texas Health Science Center Houston
RP Gould, KL (corresponding author), UTHealth, McGovern Med Sch, Weatherhead PET Ctr, 6431 Fannin St,Room MSB 4-256, Houston, TX 77030 USA.
EM K.Lance.Gould@uth.tmc.edu
RI Johnson, Nils/HJI-9416-2023
FU St. Jude Medical (CONTRAST) [NCT02184117]; Volcano/Philips Corporation
   (DEFINE-FLOW) [NCT02328820]
FX an institutional licensing/consulting agreement with Boston Scientific
   for the smart minimum FFR algorithm; and has received institutional
   research support from St. Jude Medical (CONTRAST, NCT02184117) and
   Volcano/Philips Corporation (DEFINE-FLOW, NCT02328820) for studies using
   intracoronary pressure/flow sensors.
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NR 48
TC 91
Z9 94
U1 0
U2 21
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0735-1097
EI 1558-3597
J9 J AM COLL CARDIOL
JI J. Am. Coll. Cardiol.
PD NOV 27
PY 2018
VL 72
IS 21
BP 2643
EP 2662
PG 20
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA HA9AO
UT WOS:000450586600011
PM 30466522
OA hybrid
DA 2025-06-11
ER

PT J
AU Aleem, M
   Maqsood, H
   Younus, S
   Zafar, AF
   Talpur, AS
   Shakeel, H
AF Aleem, Mudassar
   Maqsood, Hamza
   Younus, Shifa
   Zafar, Ahmed F.
   Talpur, Abdul Subhan
   Shakeel, Hassan
TI Fibroblast Growth Factor 21 and Its Association With Oxidative Stress
   and Lipid Profile in Type 2 Diabetes Mellitus
SO CUREUS JOURNAL OF MEDICAL SCIENCE
LA English
DT Article
DE fibroblast growth factor; type 2 diabetes; oxidative stress;
   dyslipidemia; lipids
AB Introduction
   Cardiovascular diseases are the leading cause of mortality in diabetic patients. Oxidative stress and mitochondria! dysfunction lead to diabetic cardiomyopathy (DCM) characterized by impaired cardiac structure and function. Hyperglycemia causes oxidative stress, which can lead to microvascular complications, macrovascular complications, and atherosclerosis. Peripheral tissues produce fibroblast growth factor 21 (FGF-21), which has anti-inflammatory properties, increases oxidation of fatty acids, and improves insulin sensitivity. Its increased levels are found in metabolic syndrome and type 2 diabetes mellitus and may also lead to coronary heart disease. Our study sought to measure the serum FGF-21 levels and their associations with lipid profile parameters and oxidative stress in patients with type 2 diabetes mellitus.
   Methodology
   One-hundred fifty (150) patients of both genders with type 2 diabetes mellitus were recruited along with 150 controls. Simple random sampling was done. After taking relevant history and physical examination, we drew venous blood samples of each patient and sent them to the institutional laboratory for analysis of fasting blood sugar (FBS) levels, glycated hemoglobin (HbA1C), lipid profile, and FGF-21 serum levels. Oxidative stress parameter malondialdehyde (MDA) was estimated and the total antioxidant status by ferric reducing antioxidant power assay (FRAP) was assessed. Patients were followed up after three months to record the glycemic index, and the values were recorded. We used SPSS Software 25.0 (SPSS, Inc., Chicago, USA) to analyze the data. For consideration of results to be statistically significant, a x value of < 0.05 was selected.
   Results
   The levels of serum cholesterol, triglycerides, and low-density lipoprotein (LDL) cholesterol were increased in diabetics compared to controls and were statistically significant (p<0.05). High-density lipoprotein (HDL) cholesterol was lower in diabetic patients as compared to the controls (p<0.05). There was a statistically significant increase in the level of MDA in diabetics compared to controls (p(<)0.005). Serum levels of total antioxidant status (FRAP) were decreased in diabetics in comparison with controls (p(<)0.00.5). Serum FGF-21 level was statistically increased in diabetics compared to controls (p(<)0.005). FGF-21 and MDA are positively correlated and FGF-21 and FRAP are negatively correlated. Serum FGF-21 is positively correlated with total cholesterol, triglycerides, serum LDL cholesterol, and HDL cholesterol.
   Conclusion
   Our study concludes that there is a significant correlation between fibroblast growth factor 21, oxidative stress, and abnormal lipid profile in type 2 diabetic patients. FGF-21 could be the target of certain medications used to treat metabolic disorders and obesity.
C1 [Aleem, Mudassar; Maqsood, Hamza; Younus, Shifa; Zafar, Ahmed F.] Nishtar Med Univ, Internal Med, Multan, Pakistan.
   [Talpur, Abdul Subhan] Liaquat Univ Med & Hlth Sci, Med, Jamshoro, Pakistan.
   [Shakeel, Hassan] Nishtar Med Univ, Neurol, Multan, Pakistan.
C3 Liaquat University of Medical & Health Sciences
RP Maqsood, H (corresponding author), Nishtar Med Univ, Internal Med, Multan, Pakistan.
EM hammadmasood62@gmail.com
RI Shakeel, Hassan/AAC-1749-2021
OI Younus, Shifa/0000-0001-9250-0499
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NR 21
TC 3
Z9 4
U1 0
U2 0
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
EI 2168-8184
J9 CUREUS J MED SCIENCE
JI Cureus J Med Sci
PD SEP 4
PY 2021
VL 13
IS 9
AR e17723
DI 10.7759/cureus.17723
PG 6
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA UM5AB
UT WOS:000693341600003
PM 34659937
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Cocco, G
   Chu, D
AF Cocco, G.
   Chu, D.
TI Stress-induced cardiomyopathy: A review
SO EUROPEAN JOURNAL OF INTERNAL MEDICINE
LA English
DT Review
DE stress-induced cardiomyopathy; left ventricular apical ballooning;
   takotsubo
ID CORONARY-HEART-DISEASE; ST-SEGMENT ELEVATION; CHEST-PAIN; TAKO-TSUBO;
   ANGINA-PECTORIS; SYNDROME-X; TAKOTSUBO CARDIOMYOPATHY;
   MYOCARDIAL-INFARCTION; ARTERY STENOSIS; WOMEN
AB In clinical practice it is essential to bear stress-induced cardiomyopathy (SICMP) in mind as it is an insufficiently known cardiac pathology that mimics acute coronary syndromes (ACS), often with signs of cardiac failure. In the chronic phase, it poses differential diagnostic problems with regard to coronary artery pathology. Taxonomic confusion, due to the pathology also being called "takotsubo" or "ampulla cardiomyopathy", has resulted in inappropriate diagnoses and therapy. Available evidence strongly suggests that, in the presence of several cardiac risk factors, excessive sympathetic stimulation may induce this cardiomyopathy. The predilection of this cardiomyopathy for Mediterranean and Indo-Asian women, who represent 85% of cases, is probably explained by the fact that there is a significant correlation between female gender, a short (<158 cm) stature, a small (<1.9 m(2)) body surface area, and hypoplastic coronary arteries. Furthermore, 40% of SICMP patients have a hypoplastic branching of the coronary arteries in the apical region of the heart. This anomaly strongly favors the apical localization of the dyskinesia. The prognosis of SICMP is good as far as life expectancy is concerned. However, in most cases, the symptoms become chronic, medical treatment rarely improves dyspnea and chest pain, and the quality of life is, therefore, reduced. In this paper, we address diagnostic misunderstandings and we review the clinical and pathophysiological features of SICMP. (C) 2007 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.
RP Cocco, G (corresponding author), Marktgasse 10a,Postfach 119, CH-4310 Rheinfelden 1, Switzerland.
EM praxis@cocco.ch
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NR 91
TC 31
Z9 37
U1 0
U2 1
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0953-6205
EI 1879-0828
J9 EUR J INTERN MED
JI Eur. J. Intern. Med.
PD SEP
PY 2007
VL 18
IS 5
BP 369
EP 379
DI 10.1016/j.ejim.2007.02.021
PG 11
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 216VW
UT WOS:000249908100004
PM 17693225
DA 2025-06-11
ER

PT J
AU Reynolds, HR
   Hausvater, A
   Carney, K
AF Reynolds, Harmony R.
   Hausvater, Anais
   Carney, Kerrilynn
TI Test Selection for Women with Suspected Stable Ischemic Heart Disease
SO JOURNAL OF WOMENS HEALTH
LA English
DT Review
DE noninvasive stress testing; coronary computed tomographic angiography;
   stable ischemic heart disease; ischemia; women
ID CORONARY-ARTERY-DISEASE; FRACTIONAL FLOW RESERVE; INCREMENTAL PROGNOSTIC
   VALUE; ACUTE MYOCARDIAL-INFARCTION; COMPUTED-TOMOGRAPHY ANGIOGRAPHY;
   VENTRICULAR EJECTION FRACTION; CARDIAC SYNDROME-X; 5-YEAR FOLLOW-UP;
   SEX-DIFFERENCES; MICROVASCULAR DYSFUNCTION
AB Ischemic heart disease (IHD) is the leading cause of death and disability among women in the United States. Identifying IHD in women presenting with stable symptoms and stratifying their risk for an IHD event can be challenging for providers, with several different tests available. This article is meant to serve as a practical guide for clinicians treating women with potentially ischemic symptoms. Evidence and American Heart Association (AHA) recommendations regarding test selection are reviewed, with a focus on the information to be gained from each test. We outline suggested courses of action to be taken in the case of a positive or negative test. Regardless of the initial test result, clinicians should view a woman's symptom presentation as an opportunity to review and modify her risk of cardiovascular events.
C1 [Reynolds, Harmony R.; Hausvater, Anais; Carney, Kerrilynn] NYU, Sch Med, Soter Ctr Womens Cardiovasc Res, Leon H Charney Div Cardiol,Dept Med, 530 First Ave,Suite 9R, New York, NY 10016 USA.
C3 New York University
RP Reynolds, HR (corresponding author), NYU, Sch Med, Soter Ctr Womens Cardiovasc Res, Leon H Charney Div Cardiol,Dept Med, 530 First Ave,Suite 9R, New York, NY 10016 USA.
EM harmony.reynolds@nyumc.org
RI Reynolds, Harmony/AAU-3154-2021
OI Reynolds, Harmony/0000-0003-0284-0655
FU NHLBI
FX Dr. Reynolds is an investigator on the NHLBI-funded ISCHEMIA trial.
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NR 96
TC 3
Z9 3
U1 0
U2 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-9996
EI 1931-843X
J9 J WOMENS HEALTH
JI J. Womens Health
PD JUL
PY 2018
VL 27
IS 7
BP 867
EP 874
DI 10.1089/jwh.2017.6587
EA MAR 2018
PG 8
WC Public, Environmental & Occupational Health; Medicine, General &
   Internal; Obstetrics & Gynecology; Women's Studies
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; General & Internal
   Medicine; Obstetrics & Gynecology; Women's Studies
GA GO0AL
UT WOS:000429803800007
PM 29583082
DA 2025-06-11
ER

PT J
AU Djindjic, N
   Jovanovic, J
   Djindjic, B
   Jovanovic, M
   Jovanovic, JJ
AF Djindjic, Natasa
   Jovanovic, Jovica
   Djindjic, Boris
   Jovanovic, Milan
   Jovanovic, Jovana J.
TI Associations between the Occupational Stress Index and Hypertension,
   Type 2 Diabetes Mellitus, and Lipid Disorders in Middle-Aged Men and
   Women
SO ANNALS OF OCCUPATIONAL HYGIENE
LA English
DT Article
DE diabetes mellitus; dyslipidemia; hypertension; lipid disorders;
   occupational diseases; occupational stress index; stress
ID CARDIOVASCULAR RISK-FACTORS; CORONARY-HEART-DISEASE; METABOLIC SYNDROME;
   WORK STRESS; JOB STRAIN; MYOCARDIAL-INFARCTION; DEPRESSIVE SYMPTOMS;
   BLOOD-PRESSURE; MASS INDEX; OBESITY
AB Retrospective and prospective studies show that stress at work is linked to an increased risk of hypertension, diabetes mellitus, and coronary heart disease. However, the nature of the contributory job stressors and biological mechanisms need further elucidation.
   The study is aimed to determine the associations between aspects of the occupational stress index (OSI) and arterial hypertension, diabetes mellitus (DM) type 2, and lipid disorders in working middle-aged men and women.
   The cross-sectional study involved 989 middle-aged men and women in different occupations. The OSI was calculated by using standardized questionnaires. The total participation rate was 93%. Occupational stressors were divided into seven groups: High Demands, Strictness, Underload, Extrinsic Time Pressure, Noxious Exposure, Avoidance, and Conflict/Uncertainty. Serum lipid levels, glucoregulation, blood pressure, and cardiovascular risk factors were measured.
   For both women and men, the total OSI score associated significantly with DM (women: odds ratio [OR] 2.4, 95% confidence intervals [CI] 1.673.45; men: 1.21, 1.151.45), any type of dyslipidemia (women: 1.54, 1.172.03; men: 1.31, 1.241.39), and arterial hypertension (women: 1.15, 1.101.21; men: 1.58, 1.491.68). The group as a whole showed associations between total OSI and low high-density lipoprotein (HDL) cholesterol, high total cholesterol, and high triglyceride levels. Of the OSI aspects, Underload associated significantly in both men and women with arterial hypertension (women: 3.48, 1.916.31; men: 2.71, 1.963.75) and dyslipidemia (women: 3.26, 2.134.99; men: 2.11, 1.762.52). Underload was also associated with several lipid abnormalities in the group as a whole. It associated with DM in women only (4.7, 2.847.81). All remaining OSI aspects also associated significantly and positively with DM in women only. Conversely, in male workers, but not female workers, High Demand, Conflict/Uncertainty, and Extrinsic Time Pressure associated significantly with arterial hypertension. Strictness and Conflict/Uncertainty associated positively with dyslipidemia in women only. Noxious Exposures associated positively with DM and arterial hypertension in women only.
   The study provides evidence for the association of work stress with metabolic disorders and hypertension. Total OSI associated significantly with DM type 2, arterial hypertension, and dyslipidemia in both genders. Different OSI aspects associated with these health issues in gender- and occupational-specific patterns. Underload, which represents lack of social communication, simple task preparation, and underestimation of working results, associated most strongly of all OSI aspects with disease in both the sexes.
C1 Univ Nis, Fac Med, Inst Pathophysiol, Nish, Serbia.
   Univ Nis, Inst Occupat Hlth, Nish, Serbia.
C3 University of Nis; University of Nis
EM nale_dj@yahoo.com
RI Djindjic, Boris/JVD-6097-2023
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NR 50
TC 45
Z9 58
U1 0
U2 60
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0003-4878
EI 1475-3162
J9 ANN OCCUP HYG
JI Ann. Occup. Hyg.
PD NOV
PY 2012
VL 56
IS 9
BP 1051
EP 1062
DI 10.1093/annhyg/mes059
PG 12
WC Public, Environmental & Occupational Health; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health; Toxicology
GA 044TC
UT WOS:000311645500007
PM 22986427
OA Bronze
DA 2025-06-11
ER

PT J
AU Sierra, JA
   Escobar, JS
   Corrales-Agudelo, V
   Lara-Guzman, OJ
   Velasquez-Mejia, EP
   Henao-Rojas, JC
   Caro-Quintero, A
   Vaillant, F
   Munoz-Durango, KM
AF Sierra, Jelver A.
   Escobar, Juan S.
   Corrales-Agudelo, Vanessa
   Lara-Guzman, Oscar J.
   Velasquez-Mejia, Eliana P.
   Henao-Rojas, Juan C.
   Caro-Quintero, Alejandro
   Vaillant, Fabrice
   Munoz-Durango, Katalina Mun
TI Consumption of golden berries (Physalis peruviana L.) might reduce
   biomarkers of oxidative stress and alter gut permeability in men without
   changing inflammation status or the gut microbiota
SO FOOD RESEARCH INTERNATIONAL
LA English
DT Article
DE Food intake markers; Cape gooseberry; Antioxidant status; Metabolomics;
   Microbiome
ID CHEMICAL-COMPOSITION; ANTIOXIDANT; DISCOVERY; OBESITY; HEALTH; DIET;
   WITHANOLIDES; CHOLESTEROL; VEGETABLES; NUTRITION
AB Golden berry (Physalis peruviana) is a tropical fruit rich in antioxidants that has been proposed to be able to control the lipid profile in hypercholesterolemic patients. Dyslipidemia is an independent risk factor for cardiometabolic diseases. The gut microbiota is strongly associated with cardiometabolic risk and is involved in redox balance, intestinal permeability, and inflammation. However, the impacts of golden berry on some of these factors, including the human gut microbiota, have never been tested, and there are no tools for compliance monitoring or dietary intake assessment regarding nutritional interventions with this fruit. In the pre-post quasiexperimental nutritional intervention presented here, 18 adult men (27-49 years old) consumed golden berries (Dorada variety) for three weeks. We evaluated putative biomarkers of exposure through an untargeted metabolomics approach (liquid chromatography-mass spectrometry LC-MS), quantified the biomarkers of oxidative stress, gut permeability, and inflammation in plasma, and assessed the effects of fruit intake on the gut microbiota through 16S rRNA gene sequencing of feces (Illumina MiSeq V2). First, syringic acid and kaempferol were identified as putative biomarkers of golden berry consumption. Intervention with this fruit promoted physiological changes in the participants after three weeks, reducing the level of the oxidative stress marker 8isoprostane (-148 pg/ml; 36.1 %; p = 0.057) and slightly altering gut permeability by increasing the plasma levels of LBP (2.91 mu g/ml; 54.6 %; p = 0.0005) and I-FABP (0.15, 14.7 %, p = 0.04) without inducing significant inflammation; i.e., the levels of IL-1 beta, TNF-alpha and IL-8 changed by 0.7 (2.0 %), -4.0 (-9.6 %) and -0.4 (-1.8 %) pg/ml, respectively. Notably, the consumption of golden berries did not affect the gut microbiota of the individuals consistently but instead shifted it in a personalized manner. The compositions of the gut microbiota of a given individual at the end of intervention and one month after the end of intervention were statistically more similar to their own baseline than to a corresponding sample from a different individual. This intervention identified putative biomarkers of golden berry intake along with potential benefits of its consumption relevant to cardiometabolic disease risk reduction. Golden berries are likely to positively modulate redox balance, although this effect must be proven in a future controlled clinical trial.
C1 [Sierra, Jelver A.; Escobar, Juan S.; Corrales-Agudelo, Vanessa; Lara-Guzman, Oscar J.; Velasquez-Mejia, Eliana P.; Munoz-Durango, Katalina Mun] Vidarium Nutr Hlth & Wellness Res Ctr, Grp Empresarial Nutresa, Medellin 050023, Colombia.
   [Henao-Rojas, Juan C.; Vaillant, Fabrice] Ctr Invest Selva, Corp Colombiana Invest Agr Agrosavia, Rionegro 054048, Colombia.
   [Caro-Quintero, Alejandro] Ctr Invest Tibaitata, Corp Colombiana Invest Agr Agrosavia, Mosquera 250047, Colombia.
   [Vaillant, Fabrice] French Agr Res Ctr Int Dev CIRAD, UMR Qualisud, F-34398 Montpellier, France.
   [Vaillant, Fabrice] Univ La Reunion, Univ Montpellier, Univ dAvignon, CIRAD,Joint Res Unit UMR Qualisud,Montpellier SupA, Montpellier, France.
   [Caro-Quintero, Alejandro] Univ Nacl Colombia, Dept Biol, Bogota 111321, Colombia.
   [Munoz-Durango, Katalina Mun] Vidarium Nutr Hlth & Wellness Res Ctr, Grp Empresarial Nutresa, Calle 8 50-67, Medellin 050023, Colombia.
C3 Corporacion Colombiana de Investigacion Agropecuaria, AGROSAVIA;
   Corporacion Colombiana de Investigacion Agropecuaria, AGROSAVIA; CIRAD;
   Universite de Montpellier; AgroParisTech; University of La Reunion;
   CIRAD; Universite de Montpellier; Universidad Nacional de Colombia
RP Munoz-Durango, KM (corresponding author), Vidarium Nutr Hlth & Wellness Res Ctr, Grp Empresarial Nutresa, Calle 8 50-67, Medellin 050023, Colombia.
EM kmunoz@serviciosnutresa.com
RI Henao-Rojas, Juan/AAP-8903-2020; Corrales Agudelo,
   Vanessa/JWA-6727-2024; Vaillant, Fabrice/D-6618-2012; Escobar,
   Juan/F-7234-2013; Sierra Restrepo, Jelver Alexander/F-4970-2013;
   Lara-Guzman, Oscar Javier/A-5029-2018
OI Henao-Rojas, Juan Camilo/0000-0003-0007-6809; Sierra Restrepo, Jelver
   Alexander/0000-0001-8541-1535; Corrales-Agudelo,
   Vanessa/0000-0002-3351-3932; Lara-Guzman, Oscar
   Javier/0000-0003-2434-6228
FU Corporacion Colombiana de Investigacion Agropecuaria-Agrosavia through
   recurring transfers from the Government of Colombia; Ministry of
   Agriculture and Rural Development; Vidarium-Nutrition, Health, and
   Wellness Research Center
FX This study was funded by Corporacion Colombiana de Investigacion
   Agropecuaria-Agrosavia through recurring transfers from the Government
   of Colombia, the Ministry of Agriculture and Rural Development, and
   Vidarium-Nutrition, Health, and Wellness Research Center.
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NR 91
TC 5
Z9 5
U1 4
U2 15
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0963-9969
EI 1873-7145
J9 FOOD RES INT
JI Food Res. Int.
PD DEC
PY 2022
VL 162
AR 111949
DI 10.1016/j.foodres.2022.111949
EA SEP 2022
PN A
PG 11
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA 5K2AQ
UT WOS:000869534100008
PM 36461284
DA 2025-06-11
ER

PT J
AU Kim, JS
   Hong, SM
   Kim, D
   Cho, YE
AF Kim, Ji-Su
   Hong, Sun-Mee
   Kim, Do-Kyun
   Cho, Young-Eun
TI Protective Effects of Plum on Liver and Gut Injury in Metabolic
   Dysfunction-Associated Fatty Liver Disease
SO NUTRIENTS
LA English
DT Article
DE metabolic dysfunction-associated fatty liver disease (MASLD);
   freeze-dried plum (FDP); liver damage; gut damage
ID FRUIT; L.
AB Metabolic dysfunction-associated fatty liver disease (MASLD), a persistent liver condition associated with metabolic syndrome, is primarily caused by excessive fructose intake and a typical Western diet. Because there is currently only one approved treatment, lifestyle and dietary interventions are crucial. This study assessed the effects of dietary intervention involving freeze-dried plum (FDP), a natural source of antioxidants containing diverse polyphenols. This study aimed to assess its potential as a protective agent against the gut-liver axis and its therapeutic effects on liver injury and gut permeability issues associated with MASLD. We indicate that 10% FDP intake restored gut barrier proteins and reduced serum endotoxin levels in the MASLD mouse models. Additionally, 10% FDP intake significantly reduced hepatic oxidative stress, lipid metabolism, and fibrosis marker levels. Interestingly, FDP intake significantly reduced the levels of inflammatory cytokine tumor necrosis factor-alpha and markers of liver damage, such as serum alanine aminotransferase/aspartate aminotransferase and hepatic triglycerides. These results highlight that dietary intervention with FDP that acts as a natural antioxidant may be a significant protective and therapeutic agent against liver and gut damage caused by MASLD.
C1 [Kim, Ji-Su; Cho, Young-Eun] Andong Natl Univ, Dept Food & Nutr, Andong 36729, South Korea.
   [Hong, Sun-Mee] Marine Ind Res Inst East Sea Rim, Dept Technol Dev, Uljin 36315, South Korea.
   [Kim, Do-Kyun] Jeonbuk Natl Univ, Korea Zoonosis Res Inst, Iksan 54531, South Korea.
C3 Gyeongkuk National University; Jeonbuk National University
RP Cho, YE (corresponding author), Andong Natl Univ, Dept Food & Nutr, Andong 36729, South Korea.; Kim, D (corresponding author), Jeonbuk Natl Univ, Korea Zoonosis Res Inst, Iksan 54531, South Korea.
EM witn6265@naver.com; hongsunmee@mire.re.kr; dkkim714@jbnu.ac.kr;
   yecho@anu.ac.kr
OI , Young Eun/0000-0001-9864-0265; Hong, Sun Mee/0000-0002-6142-8559
FU National Research Foundation of Korea (NRF) [2024-00340542,
   2022R1C1C1006334]; National Research Foundation of Korea (NRF) - Korean
   government (MSIT)
FX This research was funded by the National Research Foundation of Korea
   (NRF) grant funded by the Korean government (MSIT) (No. 2024-00340542,
   2022R1C1C1006334).
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NR 38
TC 0
Z9 0
U1 5
U2 6
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD NOV
PY 2024
VL 16
IS 21
AR 3760
DI 10.3390/nu16213760
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA L6I5D
UT WOS:001351733900001
PM 39519593
OA gold
DA 2025-06-11
ER

PT J
AU Fujiwara, S
   Izawa, T
   Mori, M
   Atarashi, M
   Yamate, J
   Kuwamura, M
AF Fujiwara, Sakura
   Izawa, Takeshi
   Mori, Mutsuki
   Atarashi, Machi
   Yamate, Jyoji
   Kuwamura, Mitsuru
TI Dietary iron overload enhances Western diet induced hepatic inflammation
   and alters lipid metabolism in rats sharing similarity with human DIOS
SO SCIENTIFIC REPORTS
LA English
DT Article
ID NF-KAPPA-B; FATTY LIVER-DISEASE; INSULIN-RESISTANCE; SERUM FERRITIN;
   NONALCOHOLIC STEATOHEPATITIS; OXIDATIVE STRESS; GENE-EXPRESSION;
   PATHOGENESIS; ACTIVATION; FIBROSIS
AB Hepatic iron overload is often concurrent with nonalcoholic fatty liver disease (NAFLD). Dysmetabolic iron overload syndrome (DIOS) is characterized by an increase in the liver and body iron stores and metabolic syndrome components. Increasing evidences suggest an overlap between NAFLD with iron overload and DIOS; however, the mechanism how iron is involved in their pathogenesis remains unclear. Here we investigated the role of iron in the pathology of a rat model of NAFLD with iron overload. Rats fed a Western (high-fat and high-fructose) diet for 26 weeks represented hepatic steatosis with an increased body weight and dyslipidemia. Addition of dietary iron overload to the Western diet feeding further increased serum triglyceride and cholesterol, and enhanced hepatic inflammation; the affected liver had intense iron deposition in the sinusoidal macrophages/Kupffer cells, associated with nuclear translocation of NF kappa B and upregulation of Th1/M1-related cytokines. The present model would be useful to investigate the mechanism underlying the development and progression of NAFLD as well as DIOS, and to elucidate an important role of iron as one of the "multiple hits " factors.
C1 [Fujiwara, Sakura; Izawa, Takeshi; Mori, Mutsuki; Atarashi, Machi; Yamate, Jyoji; Kuwamura, Mitsuru] Osaka Metropolitan Univ, Lab Vet Pathol, 1-58 Rinku Orai Kita, Osaka 5988531, Japan.
C3 Osaka Metropolitan University
RP Izawa, T (corresponding author), Osaka Metropolitan Univ, Lab Vet Pathol, 1-58 Rinku Orai Kita, Osaka 5988531, Japan.
EM takeshi.izawa@omu.ac.jp
RI Kuwamura, Mitsuru/E-4659-2012
OI Izawa, Takeshi/0000-0003-3236-6050
FU JSPS KAKENHI;  [20K06415]; Grants-in-Aid for Scientific Research
   [20K06415] Funding Source: KAKEN
FX AcknowledgementsWe thank Tomoe Matsuo, Nana Hamachi, and Youko Igakura
   for their excellent technical support. This work is supported by JSPS
   KAKENHI (Grant Number 20K06415).
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NR 80
TC 8
Z9 8
U1 1
U2 8
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD DEC 10
PY 2022
VL 12
IS 1
DI 10.1038/s41598-022-25838-3
PG 13
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 7A2FC
UT WOS:000898277000006
PM 36496443
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Watroba, M
   Szukiewicz, D
AF Watroba, Mateusz
   Szukiewicz, Dariusz
TI Sirtuins at the Service of Healthy Longevity
SO FRONTIERS IN PHYSIOLOGY
LA English
DT Review
DE sirtuins; anti-aging mechanisms; caloric restriction; neurodegeneration
   prevention; metabolic austerity; anti-inflammatory action; protective
   effects
ID NF-KAPPA-B; EXTENDS LIFE-SPAN; DEPENDENT GENE-EXPRESSION;
   TYROSINE-PHOSPHATASE 1B; HEPATOCELLULAR-CARCINOMA; HEMATOPOIETIC STEM;
   ISCHEMIA-REPERFUSION; CALORIE RESTRICTION; SIRT1 ACTIVATOR; FATTY LIVER
AB Sirtuins may counteract at least six hallmarks of organismal aging: neurodegeneration, chronic but ineffective inflammatory response, metabolic syndrome, DNA damage, genome instability, and cancer incidence. Moreover, caloric restriction is believed to slow down aging by boosting the activity of some sirtuins through activating adenosine monophosphate-activated protein kinase (AMPK), thus raising the level of intracellular nicotinamide adenine dinucleotide (NAD(+)) by stimulating NAD(+) biosynthesis. Sirtuins and their downstream effectors induce intracellular signaling pathways related to a moderate caloric restriction within cells, mitigating reactive oxygen species (ROS) production, cell senescence phenotype (CSP) induction, and apoptosis as forms of the cellular stress response. Instead, it can promote DNA damage repair and survival of cells with normal, completely functional phenotypes. In this review, we discuss mechanisms of sirtuins action toward cell-conserving phenotype associated with intracellular signaling pathways related to moderate caloric restriction, as well as some tissue-specific functions of sirtuins, especially in the central nervous system, heart muscle, skeletal muscles, liver, kidneys, white adipose tissue, hematopoietic system, and immune system. In this context, we discuss the possibility of new therapeutic approaches.
C1 [Watroba, Mateusz; Szukiewicz, Dariusz] Med Univ Warsaw, Fac Hlth Sci, Dept Biophys Physiol & Pathophysiol, Warsaw, Poland.
C3 Medical University of Warsaw
RP Watroba, M (corresponding author), Med Univ Warsaw, Fac Hlth Sci, Dept Biophys Physiol & Pathophysiol, Warsaw, Poland.
EM mateusz.watroba@wum.edu.pl
RI Szukiewicz, Dariusz/U-3141-2018
OI Szukiewicz, Dariusz/0000-0002-0124-060X
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NR 183
TC 37
Z9 41
U1 2
U2 11
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1664-042X
J9 FRONT PHYSIOL
JI Front. Physiol.
PD NOV 25
PY 2021
VL 12
AR 724506
DI 10.3389/fphys.2021.724506
PG 14
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA XM8ZG
UT WOS:000729107100001
PM 34899370
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Ryu, H
   Jung, J
   Moon, J
AF Ryu, Hosihn
   Jung, Jiyeon
   Moon, Jihyun
TI Health promotion program for office workers with SEM based on the WHO's
   healthy workplace framework
SO HEALTH PROMOTION INTERNATIONAL
LA English
DT Article
DE health promotion; social ecological model; World Health Organization;
   office worker; effectiveness
ID PHYSICAL-ACTIVITY; SEDENTARY TIME; METABOLIC SYNDROME; WORKSITE; RISK;
   INTERVENTIONS; ASSOCIATION; BEHAVIOR; POLICIES; DISEASE
AB This study attempts to develop and verify the effectiveness of a health promotion program for office workers based on the social ecological model and the World Health Organization's Healthy Workplace Framework. This study involved 272 office workers of a small and medium-sized enterprise in Korea. Data were analyzed through descriptive statistics, repeated measures analysis of variance (ANOVA) and Bonferroni correction using SPSS/WIN 23.0. Workplace environmental support was provided to all workers, while a 6-month intensive core program based on social support was implemented for the intensive management group. Based on the participation rate, individuals were divided into the core and dropout groups. In all office workers, there were negative changes in high-density lipoprotein cholesterol and job stress during the period. Meanwhile, the intensive group showed significant changes in body mass index and diastolic blood pressure. The study suggests that the organization's support for a healthy environment and an individual's continued participation based on social support are essential for the effectiveness of a health promotion program for office workers.
C1 [Ryu, Hosihn; Jung, Jiyeon; Moon, Jihyun] Korea Univ, Coll Nursing, Seoul 02841, South Korea.
C3 Korea University
RP Jung, J (corresponding author), Korea Univ, Coll Nursing, Seoul 02841, South Korea.
EM hepburn86@korea.ac.kr
RI Jung, Jiyeon/AAD-7727-2021
OI Jung, Jiyeon/0000-0002-8295-3424
FU Basic Science Research Program through the National Research Foundation
   of Korea [NRF-2015R1D1A1A01056938]
FX This research was supported by the Basic Science Research Program
   through the National Research Foundation of Korea (Grant number:
   NRF-2015R1D1A1A01056938, PI: RYU).
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NR 56
TC 6
Z9 6
U1 3
U2 17
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0957-4824
EI 1460-2245
J9 HEALTH PROMOT INT
JI Health Promot. Int.
PD DEC
PY 2020
VL 35
IS 6
BP 1369
EP 1382
DI 10.1093/heapro/daaa007
PG 14
WC Health Policy & Services; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services; Public, Environmental & Occupational
   Health
GA RF0UY
UT WOS:000634564700013
PM 32068840
DA 2025-06-11
ER

PT J
AU Fernández-Tomé, S
   Hernández-Ledesma, B
AF Fernandez-Tome, Samuel
   Hernandez-Ledesma, Blanca
TI Current state of art after twenty years of the discovery of bioactive
   peptide lunasin
SO FOOD RESEARCH INTERNATIONAL
LA English
DT Review
DE Bioactive peptide; Lunasin; Health benefits; Chronic diseases;
   Bioavailability; Chemoprevention
ID CHENOPODIUM-QUINOA WILLD.; SOYPEPTIDE LUNASIN; PROTEASE INHIBITOR;
   OXIDATIVE STRESS; SOYBEAN PEPTIDE; CANCER CELLS; DIGESTION;
   BIOAVAILABILITY; ANTIOXIDANT; PROTEINS
AB Non-communicable diseases have become the medical challenge of the 21st century because of their high incidence and mortality rates. Accumulating evidence has suggested that the modulation of diet and other lifestyle habits is the best strategy for the prevention of these diseases. An increasing number of dietary compounds have been found to exert health promoting benefits beyond their nutritional effects. Among them, lunasin is considered one of the most studied bioactive peptides. Since its discovery in soybean twenty years ago, many researchers around the world have focused their studies on demonstrating the chemopreventive and chemotherapeutic activity of lunasin. Moreover, in the last years, promising protective effects of this peptide against hypercholesterolemia, obesity, metabolic syndrome and associated cardiovascular disorders, and inflammatory and immune-regulated diseases have been described. This review summarizes recent remarkable advances on the use of peptide lunasin as a potential functional ingredient to provide health benefits. Moreover, novel aspects related to the influence of lunasin's digestion and bioavailability, the mechanisms of action proposed to explain the underlying biological properties, and the incorporation of this peptide into nutritional supplements are critically discussed.
C1 [Fernandez-Tome, Samuel] Hosp Univ La Princesa, Inst Invest Sanitaria Princesa IIS IP, CIBEREHD, Madrid, Spain.
   [Hernandez-Ledesma, Blanca] CSIC UAM, CEI UAM CSIC, CIAL, Inst Invest Ciencias Alimentac, Madrid, Spain.
C3 Hospital de La Princesa; CIBER - Centro de Investigacion Biomedica en
   Red; CIBEREHD; Consejo Superior de Investigaciones Cientificas (CSIC);
   CSIC-UAM - Instituto de Investigacion en Ciencias de la Alimentacion
   (CIAL)
RP Hernández-Ledesma, B (corresponding author), CSIC UAM, CEI UAM CSIC, CIAL, Inst Invest Ciencias Alimentac, Madrid, Spain.
EM b.hernandez@csic.es
RI Hernandez-Ledesma, Blanca/M-8637-2013; Fernandez-Tome,
   Samuel/N-6196-2019
OI Hernandez-Ledesma, Blanca/0000-0001-7192-6044; Fernandez-Tome,
   Samuel/0000-0002-6893-4833
FU Ministry of Economy and Competitiveness (MINECO, Spain)
   [AGL2015-66886-R]; Instituto de Salud Carlos III (Sara Borrell
   fellowship) [CD17/00014]
FX This work has received financial support from Ministry of Economy and
   Competitiveness (MINECO, Spain) through the project AGL2015-66886-R. SFT
   is currently funded by the Instituto de Salud Carlos III (Sara Borrell
   fellowship CD17/00014).
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NR 56
TC 31
Z9 34
U1 2
U2 65
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0963-9969
EI 1873-7145
J9 FOOD RES INT
JI Food Res. Int.
PD FEB
PY 2019
VL 116
BP 71
EP 78
DI 10.1016/j.foodres.2018.12.029
PG 8
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA HL7TC
UT WOS:000458942900008
PM 30716999
DA 2025-06-11
ER

PT J
AU Rotter, D
   Peiris, H
   Grinsfelder, DB
   Martin, AM
   Burchfield, J
   Parra, V
   Hull, C
   Morales, CR
   Jessup, CF
   Matusica, D
   Parks, BW
   Lusis, AJ
   Nguyen, NUN
   Oh, M
   Iyoke, I
   Jakkampudi, T
   McMillan, DR
   Sadek, HA
   Watt, MJ
   Gupta, RK
   Pritchard, MA
   Keating, DJ
   Rothermel, BA
AF Rotter, David
   Peiris, Heshan
   Grinsfelder, D. Bennett
   Martin, Alyce M.
   Burchfield, Jana
   Parra, Valentina
   Hull, Christi
   Morales, Cyndi R.
   Jessup, Claire F.
   Matusica, Dusan
   Parks, Brian W.
   Lusis, Aldons J.
   Ngoc Uyen Nhi Nguyen
   Oh, Misook
   Iyoke, Israel
   Jakkampudi, Tanvi
   McMillan, D. Randy
   Sadek, Hesham A.
   Watt, Matthew J.
   Gupta, Rana K.
   Pritchard, Melanie A.
   Keating, Damien J.
   Rothermel, Beverly A.
TI Regulator of Calcineurin 1 helps coordinate whole-body metabolism and
   thermogenesis
SO EMBO REPORTS
LA English
DT Article
DE adaptive thermogenesis; Down syndrome; obesity; RCAN1; sarcolipin
ID BROWN ADIPOSE-TISSUE; MUSCLE-BASED THERMOGENESIS; SYNDROME CRITICAL
   REGION; DOWN-SYNDROME; SKELETAL-MUSCLE; ENERGY-EXPENDITURE; OXIDATIVE
   STRESS; LIPID-METABOLISM; SARCOLIPIN; RCAN1
AB Increasing non-shivering thermogenesis (NST), which expends calories as heat rather than storing them as fat, is championed as an effective way to combat obesity and metabolic disease. Innate mechanisms constraining the capacity for NST present a fundamental limitation to this approach, yet are not well understood. Here, we provide evidence that Regulator of Calcineurin 1 (RCAN1), a feedback inhibitor of the calcium-activated protein phosphatase calcineurin (CN), acts to suppress two distinctly different mechanisms of non-shivering thermogenesis (NST): one involving the activation of UCP1 expression in white adipose tissue, the other mediated by sarcolipin (SLN) in skeletal muscle. UCP1 generates heat at the expense of reducing ATP production, whereas SLN increases ATP consumption to generate heat. Gene expression profiles demonstrate a high correlation between Rcan1 expression and metabolic syndrome. On an evolutionary timescale, in the context of limited food resources, systemic suppression of prolonged NST by RCAN1 might have been beneficial; however, in the face of caloric abundance, RCAN1-mediated suppression of these adaptive avenues of energy expenditure may now contribute to the growing epidemic of obesity.
C1 [Rotter, David; Grinsfelder, D. Bennett; Burchfield, Jana; Hull, Christi; Morales, Cyndi R.; Ngoc Uyen Nhi Nguyen; Oh, Misook; Iyoke, Israel; Jakkampudi, Tanvi; McMillan, D. Randy; Sadek, Hesham A.; Rothermel, Beverly A.] Univ Texas Southwestern Med Ctr Dallas, Div Cardiol, Dept Internal Med, Dallas, TX 75390 USA.
   [Peiris, Heshan; Martin, Alyce M.; Keating, Damien J.] Flinders Univ S Australia, Dept Human Physiol, Adelaide, SA, Australia.
   [Peiris, Heshan; Martin, Alyce M.; Keating, Damien J.] Flinders Univ S Australia, Ctr Neurosci, Adelaide, SA, Australia.
   [Parra, Valentina] Univ Chile, Fac Chem & Pharmaceut Sci, Santiago, Chile.
   [Parra, Valentina] Univ Chile, Fac Med, Adv Ctr Chron Dis ACCDiS, Santiago, Chile.
   [Parra, Valentina] Univ Chile, Ctr Exercise Metab & Canc, Santiago, Chile.
   [Jessup, Claire F.; Matusica, Dusan] Flinders Univ S Australia, Dept Anat & Histol, Adelaide, SA, Australia.
   [Jessup, Claire F.; Matusica, Dusan] Flinders Univ S Australia, Ctr Neurosci, Adelaide, SA, Australia.
   [Parks, Brian W.] Univ Wisconsin, Dept Nutr Sci, 1415 Linden Dr, Madison, WI 53706 USA.
   [Lusis, Aldons J.] Univ Calif Los Angeles, Dept Med, Div Cardiol, Los Angeles, CA 90024 USA.
   [Oh, Misook] Pohang Univ Sci & Technol, Dept Chem, Pohang, South Korea.
   [McMillan, D. Randy] Childrens Med Ctr, Dallas, TX 75235 USA.
   [Watt, Matthew J.] Monash Univ, Dept Physiol, Clayton, Vic, Australia.
   [Watt, Matthew J.] Monash Univ, Monash Biomed Discovery Inst, Metab Dis & Obes Program, Clayton, Vic, Australia.
   [Gupta, Rana K.] Univ Texas Southwestern Med Ctr Dallas, Touchstone Diabet Ctr, Dallas, TX 75390 USA.
   [Gupta, Rana K.] Univ Texas Southwestern Med Ctr Dallas, Dept Internal Med, Dallas, TX USA.
   [Pritchard, Melanie A.] Monash Univ, Dept Biochem & Mol Biol, Melbourne, Vic, Australia.
   [Keating, Damien J.] SAHMRI, Adelaide, SA, Australia.
   [Rothermel, Beverly A.] Univ Texas Southwestern Med Ctr Dallas, Dept Mol Biol, Dallas, TX 75390 USA.
C3 University of Texas System; University of Texas Southwestern Medical
   Center Dallas; Flinders University South Australia; Flinders University
   South Australia; Universidad de Chile; Universidad de Chile; Universidad
   de Chile; Flinders University South Australia; Flinders University South
   Australia; University of Wisconsin System; University of Wisconsin
   Madison; University of California System; University of California Los
   Angeles; Pohang University of Science & Technology (POSTECH); Monash
   University; Monash University; University of Texas System; University of
   Texas Southwestern Medical Center Dallas; University of Texas System;
   University of Texas Southwestern Medical Center Dallas; Monash
   University; South Australian Health & Medical Research Institute
   (SAHMRI); University of Texas System; University of Texas Southwestern
   Medical Center Dallas
RP Rothermel, BA (corresponding author), Univ Texas Southwestern Med Ctr Dallas, Div Cardiol, Dept Internal Med, Dallas, TX 75390 USA.; Keating, DJ (corresponding author), Flinders Univ S Australia, Dept Human Physiol, Adelaide, SA, Australia.; Keating, DJ (corresponding author), SAHMRI, Adelaide, SA, Australia.; Rothermel, BA (corresponding author), Univ Texas Southwestern Med Ctr Dallas, Dept Mol Biol, Dallas, TX 75390 USA.
EM damien.keating@flinders.edu.au; beverly.rothermel@utsouthwestern.edu
RI KEATING, DAMIEN/KVZ-1655-2024; Gupta, Rana/R-3051-2019; Watt,
   Matthew/B-2089-2014; Nhi, Nguyen/LKN-7747-2024; Martin,
   Alyce/AAR-6179-2020; Parra, Valentina/N-3972-2018; Matusica,
   Dusan/G-8138-2011
OI Parra, Valentina/0000-0002-0080-6472; Jessup,
   Claire/0000-0003-1184-6653; Martin, Alyce/0000-0003-1631-8307; Keating,
   Damien/0000-0002-0154-8305; Nguyen, Ngoc Uyen Nhi/0000-0003-0694-3176;
   Gupta, Rana/0000-0002-9001-4531; Matusica, Dusan/0000-0001-6472-7653;
   Rotter, David/0000-0002-1751-1697; Jakkampudi, Tanvi/0000-0002-9821-8723
FU National Institutes of Health [HL072016, HL102478, 1U54HD087351,
   DK104789]; American Heart Association [11POST7950051, 13POST16520009];
   Australian National Health and Medical Research Council [APP1088737];
   National Fund for Scientific and Technological Development in Chile
   [FONDECYT 11150282, PAI 79150007]; Diabetes Australia Research Trust
   [Y16G-KEAD]; American Heart Association (AHA) [13POST16520009,
   11POST7950051] Funding Source: American Heart Association (AHA)
FX This work was supported by funding from the National Institutes of
   Health (HL072016, HL102478, 1U54HD087351, DK104789), American Heart
   Association (11POST7950051, 13POST16520009), Australian National Health
   and Medical Research Council (APP1088737), National Fund for Scientific
   and Technological Development in Chile (FONDECYT 11150282 and PAI
   79150007), and the Diabetes Australia Research Trust (Y16G-KEAD).
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NR 94
TC 33
Z9 33
U1 1
U2 17
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1469-221X
EI 1469-3178
J9 EMBO REP
JI EMBO Rep.
PD DEC
PY 2018
VL 19
IS 12
AR e44706
DI 10.15252/embr.201744706
PG 19
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA HD0XF
UT WOS:000452232000003
PM 30389725
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Vartanian, V
   Tumova, J
   Dobrzyn, P
   Dobrzyn, A
   Nakabeppu, Y
   Lloyd, RS
   Sampath, H
AF Vartanian, Vladimir
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   Lloyd, R. Stephen
   Sampath, Harini
TI 8-oxoguanine DNA glycosylase (OGG1) deficiency elicits coordinated
   changes in lipid and mitochondrial metabolism in muscle
SO PLOS ONE
LA English
DT Article
ID FATTY-ACID TRANSPORT; ALZHEIMERS-DISEASE BRAIN; BASE EXCISION-REPAIR;
   SKELETAL-MUSCLE; INSULIN-RESISTANCE; GENE-EXPRESSION; OXIDATIVE DAMAGE;
   SACCHAROMYCES-CEREVISIAE; SER326CYS POLYMORPHISM; PARKINSONS-DISEASE
AB Oxidative stress resulting from endogenous and exogenous sources causes damage to cellular components, including genomic and mitochondrial DNA. Oxidative DNA damage is primarily repaired via the base excision repair pathway that is initiated by DNA glycosylases. 8-oxoguanine DNA glycosylase (OGG1) recognizes and cleaves oxidized and ring-fragmented purines, including 8-oxoguanine, the most commonly formed oxidative DNA lesion. Mice lacking the OGG1 gene product are prone to multiple features of the metabolic syndrome, including high-fat diet-induced obesity, hepatic steatosis, and insulin resistance. Here, we report that OGG1-deficient mice also display skeletal muscle pathologies, including increased muscle lipid deposition and alterations in genes regulating lipid uptake and mitochondrial fission in skeletal muscle. In addition, expression of genes of the TCA cycle and of carbohydrate and lipid metabolism are also significantly altered in muscle of OGG1-deficient mice. These tissue changes are accompanied by marked reductions in markers of muscle function in OGG1-deficient animals, including decreased grip strength and treadmill endurance. Collectively, these data indicate a role for skeletal muscle OGG1 in the maintenance of optimal tissue function.
C1 [Vartanian, Vladimir; Lloyd, R. Stephen] Oregon Hlth & Sci Univ, Oregon Inst Occupat Hlth Sci, Portland, OR 97201 USA.
   [Tumova, Jana; Sampath, Harini] Rutgers State Univ, Dept Nutr Sci, New Brunswick, NJ USA.
   [Dobrzyn, Pawel; Dobrzyn, Agnieszka] Nencki Inst Expt Biol, Warsaw, Poland.
   [Nakabeppu, Yusaku] Kyushu Univ, Med Inst Bioregulat, Div Neurofunct Genom, Dept Immunobiol & Neurosci, Fukuoka, Japan.
   [Lloyd, R. Stephen] Oregon Hlth & Sci Univ, Dept Physiol & Pharmacol, Portland, OR 97201 USA.
   [Sampath, Harini] Rutgers State Univ, Rutgers Ctr Lipid Res, New Brunswick, NJ USA.
   [Sampath, Harini] Rutgers State Univ, New Jersey Inst Food Nutr & Hlth, Ctr Digest Hlth, New Brunswick, NJ USA.
C3 Oregon Health & Science University; Rutgers University System; Rutgers
   University New Brunswick; Polish Academy of Sciences; Nencki Institute
   of Experimental Biology of the Polish Academy of Sciences; Kyushu
   University; Oregon Health & Science University; Rutgers University
   System; Rutgers University New Brunswick; Rutgers University System;
   Rutgers University New Brunswick
RP Sampath, H (corresponding author), Rutgers State Univ, Dept Nutr Sci, New Brunswick, NJ USA.; Nakabeppu, Y (corresponding author), Kyushu Univ, Med Inst Bioregulat, Div Neurofunct Genom, Dept Immunobiol & Neurosci, Fukuoka, Japan.; Sampath, H (corresponding author), Rutgers State Univ, Rutgers Ctr Lipid Res, New Brunswick, NJ USA.; Sampath, H (corresponding author), Rutgers State Univ, New Jersey Inst Food Nutr & Hlth, Ctr Digest Hlth, New Brunswick, NJ USA.
EM yusaku@bioreg.kyushu-u.ac.jp; sampath@ifnh.rutgers.edu
RI Tumova, Jana/A-2260-2010; Dobrzyn, Agnieszka/R-4073-2016; Dobrzyn,
   Pawel/R-4076-2016; Nakabeppu, Yusaku/A-8902-2011
OI Dobrzyn, Agnieszka/0000-0002-6331-9460; Lloyd, R.
   Stephen/0000-0001-7273-372X; Dobrzyn, Pawel/0000-0002-2433-1897;
   Nakabeppu, Yusaku/0000-0002-6739-242X
FU NIH [DK100640, DK075974]; Grants-in-Aid for Scientific Research
   [17H01391] Funding Source: KAKEN
FX This work was supported by NIH DK100640 to HS and NIH DK075974 to RSL.
   The funder had no role in study design, data collection and analysis,
   decision to publish, or preparation of the manuscript.
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NR 80
TC 30
Z9 32
U1 0
U2 3
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JUL 20
PY 2017
VL 12
IS 7
AR e0181687
DI 10.1371/journal.pone.0181687
PG 19
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA FC1YQ
UT WOS:000406634500104
PM 28727777
OA Green Submitted, gold, Green Published
DA 2025-06-11
ER

PT J
AU Hsu, WH
   Pan, TM
AF Hsu, Wei-Hsuan
   Pan, Tzu-Ming
TI A novel PPARgamma agonist monascin's potential application in diabetes
   prevention
SO FOOD & FUNCTION
LA English
DT Review
ID GLYCATION END-PRODUCTS; ACTIVATED-RECEPTOR-GAMMA; HEPATIC STELLATE
   CELLS; PILOSUS-FERMENTED RICE; PPAR-GAMMA; INSULIN-RESISTANCE; NRF2
   ACTIVATION; EXPRESSION; METHYLGLYOXAL; INFLAMMATION
AB Edible fungi of the Monascus species have been used as traditional Chinese medicine in eastern Asia for several centuries. Monascus-fermented products possess a number of functional secondary metabolites, including the anti-inflammatory pigments monascin and ankaflavin. Monascin has been shown to prevent or ameliorate several conditions, including hypercholesterolemia, hyperlipidemia, diabetes, and obesity. Recently, monascin has been shown to improve hyperglycemia, attenuate oxidative stress, inhibit insulin resistance, and suppress inflammatory cytokine production. In our recent study, we have found that monascin is a peroxisome proliferator-activated receptor-gamma (PPARgamma) agonist. The PPARgamma agonist activity had been investigated and its exerted benefits are inhibition of inflammation in methylglyoxal (MG)-treated rats, prevention of pancreas impairment causing advanced glycation endproducts (AGEs), promotion of insulin expression in vivo and in vitro, and attenuated carboxymethyllysine (CML)-induced hepatic stellate cell (HSC) activation in the past several years. Moreover, our studies also demonstrated that monascin also activated nuclear factor-erythroid 2-related factor 2 (Nrf2) in pancreatic RIN-m5F cell line thereby invading methylglyoxal induced pancreas dysfunction. In this review, we focus on the chemo-preventive properties of monascin against metabolic syndrome through PPARgamma and Nrf2 pathways.
C1 [Hsu, Wei-Hsuan; Pan, Tzu-Ming] Natl Taiwan Univ, Coll Life Sci, Dept Biochem Sci & Technol, Taipei 10617, Taiwan.
C3 National Taiwan University
RP Hsu, WH (corresponding author), Natl Taiwan Univ, Coll Life Sci, Dept Biochem Sci & Technol, 1,Sec 4,Roosevelt Rd, Taipei 10617, Taiwan.
EM tmpan@ntu.edu.tw
RI Pan, Tzu-Ming/KHX-6323-2024; Hsu, WeiHsuan/KFQ-3566-2024
OI PAN, TZU-MING/0000-0002-9865-1893; Hsu, Wei-Hsuan/0000-0002-6598-6435
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NR 50
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Z9 32
U1 2
U2 72
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PD JUL
PY 2014
VL 5
IS 7
BP 1334
EP 1340
DI 10.1039/c3fo60575b
PG 7
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA AK3BL
UT WOS:000338297500002
PM 24752777
DA 2025-06-11
ER

PT J
AU Sepe, A
   Tchkonia, T
   Thomou, T
   Zamboni, M
   Kirkland, JL
AF Sepe, Anna
   Tchkonia, Tamara
   Thomou, Thomas
   Zamboni, Mauro
   Kirkland, James L.
TI Aging and Regional Differences in Fat Cell Progenitors - A Mini-Review
SO GERONTOLOGY
LA English
DT Review
DE Preadipocytes; Fat redistribution; Fat depot; Inflammation
ID ADIPOSE-TISSUE INFLAMMATION; ADIPOCYTE PRECURSOR CELLS;
   INSULIN-RESISTANCE; DIABETES-MELLITUS; CRUCIAL ROLE; OBESE MICE;
   T-CELLS; EXPRESSION; PREADIPOCYTES; ADIPOGENESIS
AB Fat mass and fat tissue distribution change dramatically throughout life. In old age, fat becomes dysfunctional and is redistributed from subcutaneous to intra-abdominal visceral depots as well as other ectopic sites, including bone marrow, muscle and the liver. These changes are associated with increased risk of metabolic syndrome. Fat tissue is a nutrient storage, endocrine and immune organ that undergoes renewal throughout the lifespan. Preadipocytes, which account for 15-50% of cells in fat tissue, give rise to new fat cells. With aging, declines in preadipocyte proliferation and differentiation likely contribute to increased systemic exposure to lipotoxic free fatty acids. Age-related fat tissue inflammation is related to changes that occur in preadipocytes and macrophages in a fat depot-dependent manner. Fat tissue inflammation frequently leads to further reduction in adipogenesis with aging, more lipotoxicity and activation of cellular stress pathways that, in turn, exacerbate inflammatory responses of preadipocytes and immune cells, establishing self-perpetuating cycles that lead to systemic dysfunction. In this review, we will consider how inherent, age-related, depot-dependent alterations in preadipocyte function contribute to age-related fat tissue redistribution and metabolic dysfunction. Copyright (C) 2010 S. Karger AG, Basel
C1 [Sepe, Anna; Tchkonia, Tamara; Thomou, Thomas; Kirkland, James L.] Mayo Clin, Robert & Arlene Kogod Ctr Aging, Rochester, MN 55905 USA.
   [Sepe, Anna; Zamboni, Mauro; Kirkland, James L.] Univ Verona, Dept Biomed & Surg Sci, Div Geriatr, I-37100 Verona, Italy.
C3 Mayo Clinic; University of Verona
RP Kirkland, JL (corresponding author), Mayo Clin, Robert & Arlene Kogod Ctr Aging, Guggenheim 7 01A,200 1st St SW, Rochester, MN 55905 USA.
EM kirkland.james@mayo.edu
RI Kirkland, James/F-9159-2016
OI ZAMBONI, Mauro/0000-0001-6961-9483; Tchkonia, Tamar/0000-0003-4623-7145
FU Cassa di Risparmio di Verona-Vicenza, Belluno, Ancona; NIH [AG013925,
   AG31736]; Ted Nash Foundation
FX The authors are grateful for the support of the Cassa di Risparmio di
   Verona-Vicenza, Belluno, Ancona (Biomedical Research Project 2007), NIH
   grants AG013925 and AG31736 (J.L.K.), and the Ted Nash Foundation
   (J.L.K.).
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NR 58
TC 179
Z9 196
U1 0
U2 18
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0304-324X
J9 GERONTOLOGY
JI Gerontology
PY 2011
VL 57
IS 1
BP 66
EP 75
DI 10.1159/000279755
PG 10
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA 698GB
UT WOS:000285580900010
PM 20110661
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Busija, DW
   Miller, AW
   Katakam, P
   Erdos, B
AF Busija, David W.
   Miller, Allison W.
   Katakam, Prasad
   Erdos, Benedek
TI Adverse effects of reactive oxygen species on vascular reactivity in
   insulin resistance
SO ANTIOXIDANTS & REDOX SIGNALING
LA English
DT Review
ID ZUCKER OBESE RATS; ENDOTHELIUM-MEDIATED RELAXATION; SMALL
   MESENTERIC-ARTERIES; NITRIC-OXIDE; METABOLIC-SYNDROME; OXIDATIVE STRESS;
   DIABETES-MELLITUS; POTASSIUM CHANNEL; CEREBRAL ARTERIOLES;
   CORONARY-ARTERIES
AB Insulin resistance (IR) has adverse effects on the reactivity of arteries and arterioles and promotes arterial hypertension and vascular occlusive diseases. Altered reactivity of resistance vessels occurs at both the endothelium and smooth-muscle levels. One major mechanism of vascular dysfunction with IR involves the augmented generation, availability, and/or actions of reactive oxygen species (ROS). Scavengers of ROS are able immediately to restore normal dilator responsiveness in arteries from IR animals. Other factors, such as increased importance of constrictor agents such as endothelin, also restrict normal dilator responses. The basis of ROS-mediated vascular dysfunction in IR may be secondary to underlying inflammatory processes throughout the arterial wall. Although ROS scavengers may be beneficial in the short term, prolonged treatments involving behavioral approaches, such as changes in diet, weight loss, and regular exercise, and pharmacological approaches, involving the use of insulin-sensitizing agents, inhibitors of the renin-angiotensin system, or administration of statins, appear to offer benefits against the detrimental vascular effects of IR. Nonetheless, the most effective approach appears to involve prevention of IR via adoption of a healthy lifestyle by young people.
C1 Wake Forest Univ, Dept Physiol & Pharmacol, Winston Salem, NC 27157 USA.
C3 Wake Forest University
RP Busija, DW (corresponding author), Wake Forest Univ, Dept Physiol & Pharmacol, Med Ctr Blvd, Winston Salem, NC 27157 USA.
EM dbusija@wfubmc.edu
RI K, P/AAL-6310-2021
OI Katakam, Prasad/0000-0002-4708-9140; Erdos, Benedek/0000-0002-9074-2491
FU NHLBI NIH HHS [HL-65380, HL-50587, HL-30260, HL-66074, HL-77731] Funding
   Source: Medline
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NR 119
TC 27
Z9 28
U1 0
U2 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1523-0864
EI 1557-7716
J9 ANTIOXID REDOX SIGN
JI Antioxid. Redox Signal.
PD JUL-AUG
PY 2006
VL 8
IS 7-8
BP 1131
EP 1140
DI 10.1089/ars.2006.8.1131
PG 10
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 070DX
UT WOS:000239501600005
PM 16910761
DA 2025-06-11
ER

PT J
AU Guillou, L
   Durand, V
   Raymond, M
   Berticat, C
AF Guillou, Leonard
   Durand, Valerie
   Raymond, Michel
   Berticat, Claire
TI Chronic refined carbohydrate consumption measured by glycemic load and
   variation in cognitive performance in healthy people
SO PERSONALITY AND INDIVIDUAL DIFFERENCES
LA English
DT Article
DE Refined carbohydrates; Diet evolution; Cognition; Sugars; High glycemic
   load; Energy intake
ID BODY-MASS INDEX; INSULIN-RESISTANCE; ALZHEIMER-DISEASE; METABOLIC
   SYNDROME; PHYSICAL-ACTIVITY; OXIDATIVE STRESS; GLUCOSE-UPTAKE; DIET
   QUALITY; ADULTS; RISK
AB A massive diet switch has occurred in the occidental world since the second half of the 20th century, with a dramatic increase in refined carbohydrate consumption generating numerous deleterious health effects. Physi-ological mechanisms associated with refined carbohydrate consumption, such as hyperinsulinemia and insulin resistance, may impact cognition in healthy people before overt obesity, metabolic disease onset or dementia. To explore this possibility, the relationship between cognitive performance and chronic refined carbohydrate consumption was studied in healthy young adults (N = 95). Evaluation of chronic refined consumption was based on the glycemic load (a proxy of glycemic and insulinemic responses) of three mealtimes at higher glycemic risk: breakfast, afternoon snacking and between-meal snacking. Immediate consumption of refined carbohydrates was experimentally controlled. High chronic between-meal glycemic load is associated to a decrease of cognitive performance for men and women in the presence of several control variables, including energy intake. The different physiological ecologies of the three meals and the interpretation of the results in terms of adaptation or maladaptation to the modern dietary environment are discussed.
C1 [Guillou, Leonard; Durand, Valerie; Raymond, Michel; Berticat, Claire] Univ Montpellier, ISEM, CNRS, EPHE,IRD, Montpellier, France.
   [Guillou, Leonard] PSL Res Univ, Ecole Normale Super, Inst Jean Nicod, Dept Etud Cognit,CNRS,UMR8129, Paris, France.
C3 Universite PSL; Ecole Pratique des Hautes Etudes (EPHE); Centre National
   de la Recherche Scientifique (CNRS); Institut de Recherche pour le
   Developpement (IRD); Universite de Montpellier; Universite PSL; Ecole
   Normale Superieure (ENS); Centre National de la Recherche Scientifique
   (CNRS); CNRS - Institute for Humanities & Social Sciences (INSHS)
RP Berticat, C (corresponding author), Univ Montpellier, ISEM, CNRS, EPHE,IRD, Montpellier, France.
EM claire.berticat@umontpellier.fr
RI Raymond, Michel/C-9049-2015
OI Guillou, Leonard/0000-0003-2623-9493; Berticat,
   Claire/0000-0003-1305-5337
FU Agence Nationale pour la Recherche "HUMANWAY" project
   [ANR-12-BSV7-0008-01]; Agence Nationale de la Recherche (ANR)
   [ANR-12-BSV7-0008] Funding Source: Agence Nationale de la Recherche
   (ANR)
FX We would like to thank the women and men who participated in this study
   and Agence Nationale pour la Recherche "HUMANWAY" project
   (ANR-12-BSV7-0008-01) for funding. This is contribution ISEM 2023-028 of
   the Institute of Evolutionary Science of Montpellier.
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NR 77
TC 3
Z9 3
U1 2
U2 7
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0191-8869
EI 1873-3549
J9 PERS INDIV DIFFER
JI Pers. Individ. Differ.
PD MAY
PY 2023
VL 206
AR 112138
DI 10.1016/j.paid.2023.112138
EA FEB 2023
PG 9
WC Psychology, Social
WE Social Science Citation Index (SSCI)
SC Psychology
GA 9U8LC
UT WOS:000947955300001
OA Bronze, Green Submitted
DA 2025-06-11
ER

PT J
AU Ji, Y
   Liang, YM
   Mak, JCW
   Ip, MSM
AF Ji, Yang
   Liang, Yingmin
   Mak, Judith C. W.
   Ip, Mary S. M.
TI Obstructive sleep apnea, intermittent hypoxia and non-alcoholic fatty
   liver disease
SO SLEEP MEDICINE
LA English
DT Review
DE Intermittent hypoxia; Non-alcoholic fatty liver disease; Obesity;
   Obstructive sleep apnea
ID POSITIVE AIRWAY PRESSURE; INSULIN-RESISTANCE; RISK-FACTORS; OXIDATIVE
   STRESS; NECK CIRCUMFERENCE; METABOLIC SYNDROME; HEPATIC STEATOSIS;
   LIPID-METABOLISM; OBESE-PATIENTS; MOUSE MODEL
AB With the current epidemic of obesity worldwide, the prevalence of various obesity-related diseases is constantly increasing. Obesity remains the strongest phenotypic risk factor in both obstructive sleep apnea (OSA) and non-alcoholic fatty liver disease (NAFLD). In OSA, intermittent hypoxia-reoxygenation and sleep fragmentation, as a result of recurrent episodes of upper airway obstruction during sleep, may give rise to a plethora of metabolic derangements downstream. Intermittent hypoxia (IH) is postulated to be an important mechanistic trigger for potential systemic impact on organs or tissues in OSA, and has served as a useful experimental model for seeking evidence for downstream effects of OSA. This narrative review focuses on the clinical association between OSA and NAFLD, and the role of IH in the progression of NAFLD in lean and diet-induced obese animal models. Understanding the roles of obesity and IH on NAFLD would advance our limited knowledge on the potential health consequences of OSA, a disease which is afflicting more and more people globally, and also in devising effective therapeutic strategies for this progressively common liver condition. (c) 2022 Elsevier B.V. All rights reserved.
C1 [Ji, Yang; Liang, Yingmin; Mak, Judith C. W.; Ip, Mary S. M.] Univ Hong Kong, Shenzhen Hosp, Resp Med, Shenzhen, Peoples R China.
   [Liang, Yingmin; Mak, Judith C. W.; Ip, Mary S. M.] Univ Hong Kong, Dept Med, Hong Kong, Peoples R China.
   [Mak, Judith C. W.] Univ Hong Kong, Dept Pharmacol, Hong Kong, Peoples R China.
   [Mak, Judith C. W.] Univ Hong Kong, Li Ka Shing Fac Med, Dept Med, Pokfulam, L8-40 Lab Block,21 Sassoon Rd, Hong Kong, Peoples R China.
   [Ip, Mary S. M.] Univ Hong Kong, Queen Mary Hosp, Dept Med, Div Resp Med, 4-F Professorial Block, Hong Kong, Peoples R China.
   [Mak, Judith C. W.] Univ Hong Kong, Dept Pharm, Hong Kong, Peoples R China.
   [Mak, Judith C. W.] Univ Hong Kong, Li Ka Shing Fac Med, Dept Pharmacol & Pharm, Pokfulam, L8-40 Lab Block,21 Sassoon Rd, Hong Kong, Peoples R China.
C3 University of Hong Kong; University of Hong Kong; University of Hong
   Kong; University of Hong Kong; University of Hong Kong; University of
   Hong Kong; University of Hong Kong
RP Mak, JCW (corresponding author), Univ Hong Kong, Li Ka Shing Fac Med, Dept Med, Pokfulam, L8-40 Lab Block,21 Sassoon Rd, Hong Kong, Peoples R China.; Ip, MSM (corresponding author), Univ Hong Kong, Queen Mary Hosp, Dept Med, Div Resp Med, 4-F Professorial Block, Hong Kong, Peoples R China.; Mak, JCW (corresponding author), Univ Hong Kong, Li Ka Shing Fac Med, Dept Pharmacol & Pharm, Pokfulam, L8-40 Lab Block,21 Sassoon Rd, Hong Kong, Peoples R China.
EM judithmak@hku.hk; msmip@hku.hk
RI Mak, Judith/C-4363-2009; Ip, Mary/C-4284-2009
OI Mak, Judith/0000-0002-8234-1313
FU Sanming Project of Medicine in Shenzhen, China [SZSM201612096]; High
   Level-hospital Program, Health Commission of Guangdong Province, China
   [HKUSZH201901010]
FX This study was financially supported by Sanming Project of Medicine in
   Shenzhen, China (Integrated Airways Programme, SZSM201612096) ; and High
   Level-hospital Program, Health Com-mission of Guangdong Province, China
   (No. HKUSZH201901010) .
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NR 183
TC 16
Z9 18
U1 1
U2 12
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1389-9457
EI 1878-5506
J9 SLEEP MED
JI Sleep Med.
PD JUL
PY 2022
VL 95
BP 16
EP 28
DI 10.1016/j.sleep.2022.04.006
EA MAY 2022
PG 13
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 1V6NP
UT WOS:000806204400003
PM 35537279
DA 2025-06-11
ER

PT J
AU Azzam, O
   Matthews, VB
   Schlaich, MP
AF Azzam, Omar
   Matthews, Vance B. B.
   Schlaich, Markus P. P.
TI Interaction between sodium-glucose co-transporter 2 and the sympathetic
   nervous system
SO CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION
LA English
DT Review
DE cardiovascular outcomes; heart failure; sodium-glucose co-transporter 2;
   sympathetic nervous system
ID REDUCED EJECTION FRACTION; SGLT2 INHIBITORS; HEART-FAILURE; METABOLIC
   SYNDROME; KIDNEY-DISEASE; BLOOD-PRESSURE; EMPAGLIFLOZIN; MORTALITY;
   MECHANISM; DENERVATION
AB Purpose of reviewSodium-glucose co-transporter 2 (SGLT2) inhibitors have taken centre stage in research and therapeutic efforts to modulate hard clinical outcomes in patients with heightened cardiovascular and renal risk profiles. Sympathetic nervous system (SNS) activation is a prominent feature across several cardiovascular and renal disease states. This review reflects on the remarkable clinical impact of SGLT2 inhibitors on cardiorenal outcomes, and navigates the evidence for a proposed clinically relevant interaction between SGLT2 and the SNS.Recent findingsSGLT2 inhibitors exert several pleiotropic effects beyond glucose-lowering. These include, but are not limited to, diuresis and natriuresis, blood pressure lowering, reduction in inflammation and oxidative stress, stimulation of erythropoiesis, and improvement in cardiac energetics. Treatment with SGLT2 inhibitors is associated with significant improvement in cardiorenal outcomes irrespective of diabetes status. In addition, evidence from preclinical studies points to a strong signal of a bidirectional temporal association between SGLT2 inhibition and reduction in SNS activation.Ongoing preclinical and clinical trials aimed at unravelling the proposed interaction between SGLT and SNS will enhance our understanding of their individual and/or collective contributions to cardiovascular disease progression and guide future targeted therapeutic interventions.
C1 [Azzam, Omar; Schlaich, Markus P. P.] Univ Western Australia, Royal Perth Hosp Unit, Royal Perth Hosp Res Fdn, Dobney Hypertens Ctr,Med Sch, Perth, Australia.
   [Azzam, Omar] Royal Perth Hosp, Dept Med, Perth, Australia.
   [Matthews, Vance B. B.] Univ Western Australia, Royal Perth Hosp Unit, Dobney Hypertens Ctr, Sch Biomed Sci, Perth, Australia.
   [Schlaich, Markus P. P.] Royal Perth Hosp, Dept Cardiol, Perth, Australia.
   [Schlaich, Markus P. P.] Royal Perth Hosp, Dept Nephrol, Perth, Australia.
   [Schlaich, Markus P. P.] Univ Western Australia, Royal Perth Hosp Unit, Dobney Chair Clin Res, Med Sch, Level 3, MRF Bldg, Rear 50 Murray St, Perth, WA 6000, Australia.
C3 East Metropolitan Health Service; Royal Perth Hospital; University of
   Western Australia; East Metropolitan Health Service; Royal Perth
   Hospital; East Metropolitan Health Service; Royal Perth Hospital;
   University of Western Australia; East Metropolitan Health Service; Royal
   Perth Hospital; East Metropolitan Health Service; Royal Perth Hospital;
   University of Western Australia; University of Western Australia; East
   Metropolitan Health Service; Royal Perth Hospital
RP Schlaich, MP (corresponding author), Univ Western Australia, Royal Perth Hosp Unit, Dobney Chair Clin Res, Med Sch, Level 3, MRF Bldg, Rear 50 Murray St, Perth, WA 6000, Australia.
EM markus.schlaich@uwa.edu.au
RI Schlaich, Markus/E-7468-2010
OI Schlaich, Markus/0000-0002-1765-0195
CR ACC, FDA APPR DAP TREAT C
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NR 70
TC 6
Z9 6
U1 0
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1062-4821
EI 1473-6543
J9 CURR OPIN NEPHROL HY
JI Curr. Opin. Nephrol. Hypertens.
PD MAR
PY 2022
VL 31
IS 2
BP 135
EP 141
DI 10.1097/MNH.0000000000000767
PG 7
WC Urology & Nephrology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology; Cardiovascular System & Cardiology
GA 9M9EX
UT WOS:000942525100001
PM 35086983
DA 2025-06-11
ER

PT J
AU Li, K
   Zhang, J
   Qin, YW
   Wei, YX
AF Li, Kun
   Zhang, Jing
   Qin, Yanwen
   Wei, Yong-Xiang
TI Association between Serum Homocysteine Level and Obstructive Sleep
   Apnea: A Meta-Analysis
SO BIOMED RESEARCH INTERNATIONAL
LA English
DT Review
ID PLASMA TOTAL HOMOCYSTEINE; OXIDATIVE STRESS; METABOLIC SYNDROME;
   RISK-FACTOR; HYPERHOMOCYSTEINEMIA; MORTALITY; MARKERS
AB Background. Obstructive sleep apnea (OSA) is a common problem that affects human health. Researches have reported a variety of results with reference to the association between OSA and serum homocysteine (Hcy) level. This meta-analysis is proposed to figure out the association between serum Hcy level and OSA. Methods. Eligible studies were identified via searching PubMed, Embase, and China National Knowledge Infrastructure (CNKI). Two independent reviewers reviewed studies. The Newcastle-Ottawa Quality Assessment Scale (NOS) was employed for quality assessment of included studies. RevMan (5.1) software and STATA (12.0) software were applied to data analyses. Results. 10 studies containing 839 subjects were included in the presentmeta-analysis; results revealed that Hcy levels in OSA group were 2.40 mu mol/l higher than that in control group (95% confidence interval: 0.6 to 4.20, P < 0.01; I-2 = 96%). Subgroup analysis showed a significant increase of serum Hcy level in OSA patients compared with healthy controls when apnea hyperpnoea index (AHI) >= 30. Conclusions. Serum Hcy levels and OSA have close-knit and significant association. Analyses demonstrated that patients with OSA had a higher serum Hcy level than healthy controls. In addition, this difference is more significant in moderate or severe OSA patients.
C1 [Li, Kun; Zhang, Jing; Qin, Yanwen; Wei, Yong-Xiang] Capital Med Univ, Beijing Anzhen Hosp, Dept Otolaryngol, Beijing 100029, Peoples R China.
C3 Capital Medical University
RP Wei, YX (corresponding author), Capital Med Univ, Beijing Anzhen Hosp, Dept Otolaryngol, Beijing 100029, Peoples R China.
EM anzhenent@163.com
RI Qin, Yanwen/AAM-6961-2020
FU Public Development and Reform Pilot Project of Beijing Municipal Medical
   Research Institute [2016-4]
FX This work was supported by the Public Development and Reform Pilot
   Project of Beijing Municipal Medical Research Institute [Grant no.
   2016-4].
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VL 2017
AR 7234528
DI 10.1155/2017/7234528
PG 7
WC Biotechnology & Applied Microbiology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Research & Experimental Medicine
GA FC2YP
UT WOS:000406705400001
PM 28831396
OA Green Published, hybrid, Green Submitted
DA 2025-06-11
ER

PT J
AU Tang, AL
   Li, C
   Zou, N
   Zhang, Q
   Liu, ML
   Zhang, X
AF Tang, Ailian
   Li, Can
   Zou, Nan
   Zhang, Qian
   Liu, Meiling
   Zhang, Xia
TI Angiotensin-(1-7) improves non-alcoholic steatohepatitis through an
   adiponectin-independent mechanism
SO HEPATOLOGY RESEARCH
LA English
DT Article
DE adiponectin; AMPK; non-alcoholic steatohepatitis
ID HIGH-FAT-DIET; ACTIVATED PROTEIN-KINASE; INCREASED CIRCULATING
   ANGIOTENSIN-(1-7); METABOLIC SYNDROME; LIVER-DISEASE; OXIDATIVE STRESS;
   SKELETAL-MUSCLE; ADIPOSE-TISSUE; MICE; RATS
AB AimRecent evidence suggests that angiotensin-(1-7) [Ang-(1-7)] could improve non-alcoholic steatohepatitis (NASH) through an adiponectin-dependent mechanism. This study aimed to investigate whether and how Ang-(1-7) influences NASH without adiponectin.
   MethodsAdiponectin knockout mice were fed with a high fat diet (HFD) or normal chow for 6months, and were subsequently infused with Ang-(1-7) or saline for 2weeks.
   ResultsWe found that HFD-fed mice showed obesity, hyperlipidemia, NASH, and significantly increased levels of serum Ang-(1-7). Chronic infusion of Ang-(1-7) could reduce body weight, absolute and relative liver weight, and serum levels of total cholesterol, triglyceride, and low-density lipoprotein cholesterol in HFD-fed mice. In addition, Ang-(1-7) treatment could attenuate hepatocellular inflammation, steatosis, and ballooning with activation of the hepatic AMP-activated protein kinase signaling pathway in HFD-fed knockout mice.
   ConclusionsThese results showed the protective role of Ang-(1-7) in the development of NASH through an adiponectin-independent mechanism, which may be partially attributed to the activation of hepatic AMP-activated protein kinase pathway.
C1 [Tang, Ailian; Li, Can; Zou, Nan; Zhang, Qian; Zhang, Xia] Chongqing Med Univ, Dept Gastroenterol & Hepatol, Affiliated Hosp 2, 76 Linjiang Rd, Chongqing 400010, Peoples R China.
   [Liu, Meiling] Chongqing Med Univ, Dept Gastroenterol & Hepatol, Affiliated Hosp 1, Chongqing, Peoples R China.
C3 Chongqing Medical University; Chongqing Medical University
RP Zhang, X (corresponding author), Chongqing Med Univ, Dept Gastroenterol & Hepatol, Affiliated Hosp 2, 76 Linjiang Rd, Chongqing 400010, Peoples R China.
EM 945907416@qq.com
FU National Natural Science Foundation of China [81100275]
FX THIS WORK WAS supported by the National Natural Science Foundation of
   China (Grant No. 81100275).
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NR 39
TC 7
Z9 7
U1 1
U2 12
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1386-6346
EI 1872-034X
J9 HEPATOL RES
JI Hepatol. Res.
PD JAN
PY 2017
VL 47
IS 1
BP 116
EP 122
DI 10.1111/hepr.12707
PG 7
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA EI3ZO
UT WOS:000392432200011
PM 26992300
DA 2025-06-11
ER

PT J
AU Varela-Lopez, A
   Bullon, P
   Battino, M
   Ramirez-Tortosa, M
   Ochoa, JJ
   Cordero, MD
   Ramirez-Tortosa, CL
   Rubini, C
   Zizzi, A
   Quiles, JL
AF Varela-Lopez, Alfonso
   Bullon, Pedro
   Battino, Maurizio
   Ramirez-Tortosa, MCarmen
   Ochoa, Julio J.
   Cordero, Mario D.
   Ramirez-Tortosa, Cesar L.
   Rubini, Corrado
   Zizzi, Antonio
   Quiles, Jose L.
TI Coenzyme Q Protects Against Age-Related Alveolar Bone Loss Associated to
   n-6 Polyunsaturated Fatty Acid Rich-Diets by Modulating Mitochondrial
   Mechanisms
SO JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL
   SCIENCES
LA English
DT Article
DE Biogenesis; Electron transport chain; Fish oil; Sunflower oil; Virgin
   olive oil
ID OXIDATIVE STRESS; METABOLIC SYNDROME; OSTEOCLAST DIFFERENTIATION; Q(10)
   SUPPLEMENTATION; PERIODONTAL-DISEASE; (PUFA)-RICH DIET; ELDERLY
   SUBJECTS; SUNFLOWER OILS; DNA DELETION; RAT
AB An age-dependent model of the periodontium was reproduced to evaluate the effect of life-long feeding on a low coenzyme Q(10) dosage in n-6, n-3 polyunsaturated fatty acid or monounsaturated fatty acid-based diets on periodontal tissues of young and old rats. Results shown that exacerbated age-related alveolar bone loss previously associated to n-6 polyunsaturated fatty acid diet was attenuated by coenzyme Q(10). Gene expression analysis suggests that involved mechanisms might be related to a restored capacity of mitochondria to adapt to aging in gingival cells from rats fed on n-6 polyunsaturated fatty acid. In particular, this could be due to an age-related increase of the rate of mitochondrial biogenesis and a better oxidative and respiratory balance in these animals. From the nutritional and clinical point of view, it is noteworthy that supplementation with coenzyme Q(10) could counteract the negative effects of n-6 polyunsaturated fatty acid on alveolar bone loss (a major feature of periodontitis) associated to age.
C1 [Varela-Lopez, Alfonso; Ochoa, Julio J.; Quiles, Jose L.] Univ Granada, Inst Nutr & Food Technol Jose Mataix Verdu, Dept Physiol, E-18071 Granada, Spain.
   [Bullon, Pedro] Univ Seville, Sch Dent, Dept Periodontol, Seville, Spain.
   [Battino, Maurizio] Univ Politecn Marche, Dip Sci Clin Specialist, Ancona, Italy.
   [Ramirez-Tortosa, MCarmen] Univ Granada, Dept Biochem & Mol Biol 2, Inst Nutr & Food Technol Jose Mataix Verdu, E-18071 Granada, Spain.
   [Cordero, Mario D.] Univ Seville, Dept Citol & Histol Normal & Patol, Seville, Spain.
   [Ramirez-Tortosa, Cesar L.] Complejo Hosp Jaen, Dept Pathol, Jaen, Spain.
   [Rubini, Corrado; Zizzi, Antonio] Univ Politecn Marche, Dip Sci Biomed & Sanita Pubbl, Ancona, Italy.
C3 University of Granada; University of Sevilla; Marche Polytechnic
   University; University of Granada; University of Sevilla; Complejo
   Hospitalario de Jaen; Marche Polytechnic University
RP Quiles, JL (corresponding author), Inst Nutr & Tecnol Alimentos Jose Mataix Verdu, Dept Fisiol, Lab 120,Parque Tecnol Ciencias Salud, Granada 18100, Spain.
EM jlquiles@ugr.es
RI Battino, Maurizio/E-6103-2012; Cordero, Mario/L-8006-2014;
   Ramírez-Tortosa, César/F-2055-2016; Bullon, Pedro/E-6319-2010; Quiles,
   Jose L./C-6911-2013; Ochoa, Julio/L-8733-2014; Varela-Lopez,
   Alfonso/F-8055-2016
OI Bullon, Pedro/0000-0003-4873-4196; Quiles, Jose L./0000-0002-9048-9086;
   Ochoa, Julio/0000-0001-8976-6296; Zizzi, Antonio/0000-0001-5253-693X;
   Varela-Lopez, Alfonso/0000-0002-0504-5086
FU I+D grants from the Spanish Ministry of Education and Science
   [AGL2008-01057]; Autonomous Government of Andalusia [AGR832]; FPU
   program from the Spanish Ministry of Education
FX This study was supported by I+D grants from the Spanish Ministry of
   Education and Science (AGL2008-01057) and the Autonomous Government of
   Andalusia (AGR832). A.V-L. is recipient of a fellowship of FPU program
   from the Spanish Ministry of Education.
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NR 54
TC 22
Z9 23
U1 0
U2 14
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1079-5006
EI 1758-535X
J9 J GERONTOL A-BIOL
JI J. Gerontol. Ser. A-Biol. Sci. Med. Sci.
PD MAY
PY 2016
VL 71
IS 5
BP 593
EP 600
DI 10.1093/gerona/glv063
PG 8
WC Geriatrics & Gerontology; Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA DM5OE
UT WOS:000376398400005
PM 26219851
OA Bronze
DA 2025-06-11
ER

PT J
AU Tashiro, H
   Kuroda, S
   Mikuriya, Y
   Ohdan, H
AF Tashiro, Hirotaka
   Kuroda, Shintaro
   Mikuriya, Yoshihiro
   Ohdan, Hideki
TI Ischemia-reperfusion injury in patients with fatty liver and the
   clinical impact of steatotic liver on hepatic surgery
SO SURGERY TODAY
LA English
DT Review
DE Steatotic liver; Ischemia-reperfusion injury; Rho-kinase
ID SYSTEMIC OXYGEN PERSUFFLATION; ENDOPLASMIC-RETICULUM STRESS;
   MACROSTEATOTIC MOUSE-LIVER; ACTIVATED PROTEIN-KINASE; ASIA-PACIFIC
   REGION; NITRIC-OXIDE GAS; UNCOUPLING PROTEIN-2; RISK-FACTOR;
   ISCHEMIA/REPERFUSION INJURY; MACHINE PERFUSION
AB Hepatic steatosis is one of the most common hepatic disorders in developed countries. The epidemic of obesity in developed countries has increased with its attendant complications, including metabolic syndrome and non-alcoholic fatty liver disease. Steatotic livers are particularly vulnerable to ischemia/reperfusion injury, resulting in an increased risk of postoperative morbidity and mortality after liver surgery, including liver transplantation. There is growing understanding of the molecular and cellular mechanisms and therapeutic approaches for treating ischemia/reperfusion injury in patients with steatotic livers. This review discusses the mechanisms underlying the susceptibility of steatotic livers to ischemia/reperfusion injuries, such as mitochondrial dysfunction and signal transduction alterations, and summarizes the clinical impact of steatotic livers in the setting of hepatic resection and liver transplantation. This review also describes potential therapeutic approaches, such as ischemic and pharmacological preconditioning, to prevent ischemia/reperfusion injury in patients with steatotic livers. Other approaches, including machine perfusion, are also under clinical investigation; however, many pharmacological approaches developed through basic research are not yet suitable for clinical application.
C1 [Tashiro, Hirotaka; Kuroda, Shintaro; Mikuriya, Yoshihiro; Ohdan, Hideki] Hiroshima Univ Hosp, Dept Gastroenterol & Transplant Surg, Hiroshima 7348551, Japan.
C3 Hiroshima University
RP Tashiro, H (corresponding author), Hiroshima Univ Hosp, Dept Gastroenterol & Transplant Surg, 1-2-3 Kasumi, Hiroshima 7348551, Japan.
EM htashiro@hiroshima-u.ac.jp
RI Ohdan, Hideki/G-4719-2019
OI Ohdan, Hideki/0000-0002-9066-1288
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NR 114
TC 64
Z9 73
U1 1
U2 14
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0941-1291
EI 1436-2813
J9 SURG TODAY
JI Surg. Today
PD SEP
PY 2014
VL 44
IS 9
BP 1611
EP 1625
DI 10.1007/s00595-013-0736-9
PG 15
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA AN3QD
UT WOS:000340502300003
PM 24078000
DA 2025-06-11
ER

PT J
AU Pribis, P
   Shukitt-Hale, B
AF Pribis, Peter
   Shukitt-Hale, Barbara
TI Cognition: the new frontier for nuts and berries
SO AMERICAN JOURNAL OF CLINICAL NUTRITION
LA English
DT Article; Proceedings Paper
CT 6th International Congress on Vegetarian Nutrition (ICVN)
CY FEB 24-26, 2013
CL Loma Linda Univ, Loma Linda, CA
SP Loma Linda Univ Hlth, Kelloggs, Calif Walnut Commiss, Silk, Lifestyle Med Inst Sanitarium Hlth & Wellbeing, LifeLong Hlth, Int Nut & Dried Fruit Council
HO Loma Linda Univ
ID SUPPLEMENTATION IMPROVES MEMORY; CONCORD GRAPE JUICE; NEUROTROPHIC
   FACTOR; MEDITERRANEAN DIET; WALNUT CONSUMPTION; OXIDATIVE STRESS;
   HEALTH-BENEFITS; STYLE DIET; BRAIN; BLUEBERRY
AB The inclusion of nuts in the diet is associated with a decreased risk of coronary artery disease, hypertension, gallstones, diabetes, cancer, metabolic syndrome, and visceral obesity. Frequent consumption of berries seems to be associated with improved cardiovascular and cancer outcomes, improved immune function, and decreased recurrence of urinary tract infections; the consumption of nuts and berries is associated with reduction in oxidative damage, inflammation, vascular reactivity, and platelet aggregation, and improvement in immune functions. However, only recently have the effects of nut and berry consumption on the brain, different neural systems, and cognition been studied. There is growing evidence that the synergy and interaction of all of the nutrients and other bioactive components in nuts and berries can have a beneficial effect on the brain and cognition. Regular nut consumption, berry consumption, or both could possibly be used as an adjunctive therapeutic strategy in the treatment and prevention of several neurodegenerative diseases and age-related brain dysfunction. A number of animal and a growing number of human studies show that moderate-duration dietary supplementation with nuts, berry fruit, or both is capable of altering cognitive performance in humans, perhaps forestalling or reversing the effects of neurodegeneration in aging.
C1 [Pribis, Peter] Andrews Univ, Dept Publ Hlth & Wellness, Berrien Springs, MI 49104 USA.
   [Shukitt-Hale, Barbara] Tufts Univ, Jean Mayer USDA Human Nutr Res Ctr Aging, Neurosci & Aging Lab, Boston, MA 02111 USA.
C3 Andrews University; United States Department of Agriculture (USDA);
   Tufts University
RP Pribis, P (corresponding author), Univ New Mexico, Coll Educ, Dept Individual Family & Community Educ, Nutr & Dietet Program, Hokona Hall 156,MSC05 3040, Albuquerque, NM 87131 USA.
EM pribis@unm.edu
OI Shukitt-Hale, Barbara/0000-0002-3810-1910; Pribis,
   Peter/0000-0003-1551-3194
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NR 54
TC 57
Z9 63
U1 0
U2 37
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0002-9165
EI 1938-3207
J9 AM J CLIN NUTR
JI Am. J. Clin. Nutr.
PD JUL
PY 2014
VL 100
IS 1
SU S
BP 347S
EP 352S
DI 10.3945/ajcn.113.071506
PG 6
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Nutrition & Dietetics
GA AJ7FI
UT WOS:000337862200006
PM 24871475
OA Bronze
DA 2025-06-11
ER

PT J
AU Xu, JC
   Zhou, Q
   Liu, G
   Tan, Y
   Cai, L
AF Xu, Jiancheng
   Zhou, Qi
   Liu, Gilbert
   Tan, Yi
   Cai, Lu
TI Analysis of Serum and Urinal Copper and Zinc in Chinese Northeast
   Population with the Prediabetes or Diabetes with and without
   Complications
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Article
ID TRACE-ELEMENT STATUS; OXIDATIVE STRESS; LIFE-STYLE; CHELATION; CHILDREN;
   THERAPY; GLUCOSE; TYPE-1; IRON; PATHOGENESIS
AB This study investigated the association of copper and zinc levels in the serum or urine of patients living in northeast China, with either prediabetes or diabetes. From January 2010 to October 2011, patients with type 1 diabetes (T1D, n = 25), type 2 diabetes (T2D, n = 137), impaired fasting glucose (IFG, n = 12) or impaired glucose tolerance (IGT, n = 15), and age/gender matched controls (n = 50) were enrolled. In the T2D group, there were 24 patients with nephropathy, 34 with retinopathy, and 50 with peripheral neuropathy. Serum copper levels were significantly higher in IFG, IGT, and T2D groups. Serum zinc level was dramatically lower, and urinary zinc level was significantly higher in both T1D and T2D subjects compared with controls. The serum zinc/copper ratio was significantly lower in all the patients with IFG, ITG, T1D, and T2D. The serum copper level was positively associated with HbA1c in T2D subjects. Simvastatin treatment in T2D patients had no significant effect on serum and urinary copper and zinc. These results suggest the need for further studies of the potential impact of the imbalanced serum copper and zinc levels on metabolic syndrome, diabetes, and diabetic complications.
C1 [Xu, Jiancheng] Jilin Univ, Hosp 1, Dept Clin Lab, Changchun 130021, Peoples R China.
   [Zhou, Qi] Jilin Univ, Hosp 1, Dept Pediat, Changchun 130021, Peoples R China.
   [Liu, Gilbert; Tan, Yi; Cai, Lu] Univ Louisville, Dept Pediat, Louisville, KY 40202 USA.
C3 Jilin University; Jilin University; University of Louisville
RP Zhou, Q (corresponding author), Jilin Univ, Hosp 1, Dept Pediat, Changchun 130021, Peoples R China.
EM ty1791561@126.com; y0tan002@louisville.edu
RI Cai, Lu/AAG-9920-2019
OI Liu, Gilbert/0000-0001-9687-8931; xu, jiancheng/0000-0001-8796-271X;
   Zhou, Qi/0000-0002-5084-8697
FU National Science Foundation of China [81000330, 81273509]; Jilin Science
   and Technology Development Program [20100124]
FX This project was supported in part by Grants from National Science
   Foundation of China (no. 81000330 to J. Xu), Jilin Science and
   Technology Development Program (no. 20100124, to J. Xu), National
   Science Foundation of China (no. 81273509, to Y. Tan). The authors are
   grateful to Zhenxing Chu and Jing Jiang who have assisted them to make
   statistical analysis.
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NR 45
TC 59
Z9 60
U1 2
U2 26
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PY 2013
VL 2013
AR 635214
DI 10.1155/2013/635214
PG 11
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA 229WJ
UT WOS:000325298100001
PM 24175012
OA Green Published, Green Submitted, hybrid
DA 2025-06-11
ER

PT J
AU Ozeke, O
   Gungor, M
   Ertan, C
   Celik, A
   Aydin, D
   Erturk, O
   Hizel, SB
   Ozgen, F
   Demir, AD
   Ozer, C
AF Ozeke, Ozcan
   Gungor, Mutlu
   Ertan, Cagatay
   Celik, Atac
   Aydin, Dilek
   Erturk, Ozcan
   Hizel, Serap B.
   Ozgen, Fuat
   Demir, Ahmet D.
   Ozer, Can
TI Association of sleep apnea with coronary slow-flow phenomenon
SO JOURNAL OF CARDIOVASCULAR MEDICINE
LA English
DT Article
DE sleep apnea; slow coronary flow; TIMI frame count
ID TIMI FRAME COUNT; CARDIOVASCULAR CONSEQUENCES; MYOCARDIAL-INFARCTION;
   METABOLIC SYNDROME; PLASMA-CONCENTRATIONS; INSULIN-RESISTANCE;
   BLOOD-FLOW; DISEASE; THROMBOLYSIS; MICROCIRCULATION
AB Background Both obstructive sleep apnea (OSA) and coronary slow-flow phenomenon (CSFP) are known to share similar etiopathogenic mechanisms, such as chronic sympathetic activation, upregulation of inflammatory pathways, oxidative stress and, finally, endothelial dysfunction.
   Objective We evaluated whether there is an association between OSA and coronary flow rates.
   Method We retrospectively reviewed medical records of all patients who underwent diagnostic nocturnal polysomnography for suspected OSA. Those who had coronary angiography performed within the same year of polysomnography were divided into two main groups: those with (group 1) and without (group 2) OSA; also, angiographic coronary TIMI (thrombolysis in myocardial infarction) frame counts (TFC) were compared between the groups. Patients with coronary arterial stenosis and angiograms with inadequate filling of the coronary arteries or visualization of the distal landmarks for frame counting were excluded from the study.
   Results There was a statistically significant difference between the groups regarding TFCs. We found a significant positive correlation between mean TFC and apnea-hypopnea index (r = 0.611, P<0.001).
   Conclusion The current study demonstrated that sleep apnea impairs coronary flow rates and is associated with CSFP. J Cardiovasc Med 2012, 13:376-380
C1 [Ozeke, Ozcan; Ertan, Cagatay; Demir, Ahmet D.] Acibadem Univ, Dept Cardiol, Eskisehir, Turkey.
   [Gungor, Mutlu; Ozer, Can] Bayindir Hosp, Dept Cardiol, Ankara, Turkey.
   [Celik, Atac] Gaziosmanpasa Univ, Dept Cardiol, Tokat, Turkey.
   [Aydin, Dilek; Erturk, Ozcan; Hizel, Serap B.; Ozgen, Fuat] Bayindir Hosp, Sleep Disorder Ctr, Ankara, Turkey.
C3 Acibadem University; Bayindir Hastanesi; Bayindir Health Group; Tokat
   Gaziosmanpasa University; Bayindir Health Group; Bayindir Hastanesi
RP Ozeke, O (corresponding author), Acibadem Hastanesi, Kardiol Klin, TR-22210 Eskisehir, Turkey.
EM ozcanozeke@gmail.com
RI Celik, Atac/ABG-8065-2021; Özeke, Özcan/N-1871-2015; Demir,
   Ahmet/AAA-4183-2020; Ozeke, Ozcan/AAS-8730-2020
OI Ozeke, Ozcan/0000-0002-4770-8159
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NR 49
TC 3
Z9 5
U1 1
U2 9
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1558-2027
EI 1558-2035
J9 J CARDIOVASC MED
JI J. Cardiovasc. Med.
PD JUN
PY 2012
VL 13
IS 6
BP 376
EP 380
DI 10.2459/JCM.0b013e3283528f14
PG 5
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 940OB
UT WOS:000303901800004
PM 22450863
DA 2025-06-11
ER

PT J
AU Egger, G
   Dixon, J
AF Egger, G.
   Dixon, J.
TI Non-nutrient causes of low-grade, systemic inflammation: support for a
   'canary in the mineshaft' view of obesity in chronic disease
SO OBESITY REVIEWS
LA English
DT Article
DE Canary; inflammation; mineshaft; obesity
ID ENDOTHELIAL-CELL ACTIVATION; AIR-POLLUTION; INSULIN-RESISTANCE;
   OXIDATIVE STRESS; METABOLIC SYNDROME; SMOKING-CESSATION; SECONDHAND
   SMOKE; SLEEP DURATION; LIFE-STYLE; MARKERS
AB P>A form of low-grade, systemic inflammation ('metaflammation') is linked to many types of chronic disease. Initially, this was thought to be causally related to weight gain and obesity and a possible explanation of the link between obesity and disease. However, several lifestyle-related inducers of such inflammation, some of which are associated with obesity, but some of which are not, have now been identified. The most common of these have been nutritive related, suggesting that there could still be a relationship, either directly or indirectly, with obesity. Here we provide evidence for non-nutritive inflammatory inducers, providing further support for an earlier suggestion that while obesity, beyond a point, may have a direct link with disease, this may be neither necessary nor sufficient to explain the current epidemic of chronic disease. A more ubiquitous cause encompassing all inflammatory inducers is the modern, post-industrial environment and lifestyles emanating from this. Obesity may thus be more of 'a canary in the mineshaft', warning of bigger global problems, than just a single pathway to modern environmentally driven disease.
C1 [Egger, G.] So Cross Univ, Lismore, NSW 2480, Australia.
   [Egger, G.] Ctr Hlth Promot & Res, Sydney, NSW, Australia.
   [Dixon, J.] Baker Int Diabet Inst, Obes Res Unit, Dept Primary Hlth Care, Melbourne, Vic, Australia.
C3 Southern Cross University; Baker Heart and Diabetes Institute
RP Egger, G (corresponding author), POB 313, Balgowlah, NSW 2094, Australia.
EM eggergj@ozemail.com.au
RI Dixon, John/A-5318-2011
OI Dixon, John/0000-0001-6399-7010
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NR 85
TC 36
Z9 40
U1 0
U2 15
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1467-7881
EI 1467-789X
J9 OBES REV
JI Obes. Rev.
PD MAY
PY 2011
VL 12
IS 5
BP 339
EP 345
DI 10.1111/j.1467-789X.2010.00795.x
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 751TZ
UT WOS:000289641800004
PM 20701689
DA 2025-06-11
ER

PT S
AU Lebel, M
   Massip, L
   Garand, C
   Thorin, E
AF Lebel, Michel
   Massip, Laurent
   Garand, Chantal
   Thorin, Eric
BE Tanguay, RM
TI Ascorbate improves metabolic abnormalities in Wrn mutant mice but
   not the free radical scavenger catechin
SO AGING, CANCER, AND AGE-RELATED DISEASES: COMMON MECHANISM?
SE Annals of the New York Academy of Sciences
LA English
DT Article; Proceedings Paper
CT 13th Congress of the International-Association-of-Biomedical-Gerontology
   on Aging, Cancer and Age-Related Diseases
CY MAY 18-20, 2009
CL Quebec City, CANADA
SP Int Assoc Biomed Gerontol
DE Werner syndrome; metabolic syndrome; vitamin C; catechin; Wrn mutant
   mice
ID WERNER-SYNDROME PROTEIN; SYNDROME GENE; LACKING; CELLS
AB Werner syndrome (WS) is a premature aging disorder caused by mutations in a RecQ-like DNA helicase. Mice lacking the helicase domain of the WRN homologue exhibit many phenotypic features of WS. Importantly, mutant Wrn(Delta hel/Delta hel) mice show abnormal increases in visceral fat deposition and fasting blood triglyceride levels followed by insulin resistance and high blood glucose levels. These mice also exhibit increased heart and liver tissue reactive oxygen species concomitantly with oxidative DNA damage, indicating a pro-oxidant status. We treated mice with either ascorbate or catechin hydrate for 9 months. Vitamin C supplementation reduced oxidative stress in liver and heart tissues and reversed hypertriglyceridemia, hyperglycemia, and insulin resistance and reduced fat weight in mutant Wrn(Delta hel/Delta hel) mice. Although the free scavenger catechin hydrate also reduced oxidative DNA damage in heart and liver tissues, it did not reverse any of the metabolic phenotype aspects in treated mutant mice. Finally, vitamin C and catechin hydrate did not affect the metabolic status of wild-type mice. These results indicate that vitamin C supplementation could be beneficial for WS patients.
C1 [Lebel, Michel; Massip, Laurent; Garand, Chantal] Univ Laval, Hop Hotel Dieu Quebec, Ctr Rech Cancerol, Quebec City, PQ G1R 2J6, Canada.
C3 Laval University
RP Lebel, M (corresponding author), Univ Laval, Hop Hotel Dieu Quebec, Ctr Rech Cancerol, 9 McMahon St, Quebec City, PQ G1R 2J6, Canada.
EM michel.lebel@crhdq.ulaval.ca
RI Thorin, Eric/K-3978-2013
OI Thorin, Eric/0000-0001-5827-8935; Garand, Chantal/0000-0003-0716-6487
FU Canadian Institutes of Health Research
FX This work was supported by a grant from the Canadian Institutes of
   Health Research. M.L. is a Senior Scholar of the Fonds de la Recherche
   en Sante du Quebec.
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NR 21
TC 20
Z9 21
U1 0
U2 6
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN STREET, MALDEN 02148, MA USA
SN 0077-8923
BN 978-1-57331-796-2
J9 ANN NY ACAD SCI
JI Ann.NY Acad.Sci.
PY 2010
VL 1197
BP 40
EP 44
DI 10.1111/j.1749-6632.2010.05189.x
PG 5
WC Geriatrics & Gerontology; Multidisciplinary Sciences
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology; Science & Technology - Other Topics
GA BQO13
UT WOS:000281415100006
PM 20536831
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Kral, JG
   Näslund, E
AF Kral, John G.
   Naslund, Erik
TI Surgical treatment of obesity
SO NATURE CLINICAL PRACTICE ENDOCRINOLOGY & METABOLISM
LA English
DT Review
DE biliopancreatic diversion; brain-gut peptides; gastric bypass;
   laparoscopic adjustable banding; weight loss
ID Y GASTRIC BYPASS; VERTICAL BANDED GASTROPLASTY; BARIATRIC SURGERY;
   WEIGHT-LOSS; BILIOPANCREATIC DIVERSION; MORBID-OBESITY; ENERGY-INTAKE;
   RISK-FACTORS; FOOD-INTAKE; MANAGEMENT
AB Obesity is very prevalent. Most treatments fail owing to hard-wired survival mechanisms, linking stress and appetite, which have become grossly maladaptive in the industrial era. Antiobesity (bariatric) surgery is a seemingly drastic, efficacious therapy for this serious disease of energy surfeit. Technical progress during the last two decades has greatly improved its safety. The surgical principles of gastric restriction and/or gastrointestinal diversion have remained largely unchanged over 40 years, although mechanisms of action have been elucidated concomitant with advances in knowledge of the molecular biology of energy balance and appetite regulation. Results of bariatric surgery in large case-series followed for at least 10 years consistently demonstrate amelioration of components of the insulin-resistance metabolic syndrome and other comorbidities, significantly improving quality of life. Furthermore, bariatric surgery has convincingly been demonstrated to reduce mortality compared with nonoperative methods. This surgery requires substantial preoperative and postoperative evaluation, teaching, and monitoring to optimize outcomes. In the absence of effective societal changes to restore a healthy energy balance, bariatric surgery is an important tool for treating a very serious disease.
C1 Suny Downstate Med Ctr, Dept Surg, Brooklyn, NY 11203 USA.
   Danderyd Hosp, Dept Clin Sci, Stockholm, Sweden.
   Karolinska Inst, Stockholm, Sweden.
C3 State University of New York (SUNY) System; SUNY Downstate Health
   Sciences University; Danderyds Hospital; Karolinska Institutet
RP Kral, JG (corresponding author), Suny Downstate Med Ctr, Dept Surg, Box 40,450 Clarkson Ave, Brooklyn, NY 11203 USA.
EM jkral@downstate.edu
OI Naslund, Erik/0000-0002-0166-6344
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NR 94
TC 82
Z9 92
U1 0
U2 5
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 1745-8366
J9 NAT CLIN PRACT ENDOC
JI Nat. Clin. Pract. Endocrinol. Metab.
PD AUG
PY 2007
VL 3
IS 8
BP 574
EP 583
DI 10.1038/ncpendmet0563
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 192RQ
UT WOS:000248220400009
PM 17643128
DA 2025-06-11
ER

PT J
AU Nakamura, K
   Yamagishi, S
   Matsui, T
   Inoue, H
AF Nakamura, K
   Yamagishi, S
   Matsui, T
   Inoue, H
TI Acarbose, an α-glucosidase inhibitor, improves insulin resistance in
   fructose-fed rats
SO DRUGS UNDER EXPERIMENTAL AND CLINICAL RESEARCH
LA English
DT Article
ID CARDIOVASCULAR-DISEASE; MYOCARDIAL-INFARCTION; METABOLIC SYNDROME;
   OXIDATIVE STRESS; LONG-TERM; RISK; TOLERANCE; PREVENTION; HYPERTENSION;
   NIDDM
AB Insulin resistance is one of the determinants of postprandial hyperglycemia. Acarbose is an a-glucosidase inhibitor that delays the absorption of carbohydrates from the small intestine, thereby suppressing postprandial hyperglycemia. Recently, acarbose has been found to reduce the incidence of cardiovascular disease (CVD) in patients with diabetes. These observations suggest that intervention of postprandial hyperglycemia with acarbose is a promising strategy for the prevention of CVD in diabetic patients. However, the effects of acarbose on insulin sensitivity are not fully understood. In this study, we examined whether oral administration of acarbose could improve insulin sensitivity in fructose-fed rats, a widely used insulin-resistant animal model. Although plasma glucose levels remained unchanged during the experiments, serum insulin levels were significantly increased in fructose-fed rats, which were suppressed by 4 weeks of treatment with acarbose. Acarbose treatment also increased high-density lipoprotein levels in fructose-fed rats. Furthermore, treatment of acarbose inhibited the elevation of systolic blood pressure levels in fructose-fed rats. These results indicate that oral administration of acarbose improves insulin sensitivity in fructose-fed rats. Our present study suggests that the cardioprotecive effects of acarbose could be ascribed, at least in part, to its insulin-sensitizing property.
C1 Kurume Univ, Sch Med, Dept Med, Kurume, Fukuoka 8300011, Japan.
   Kurume Univ, Sch Med, Radioisotope Inst Basic & Clin Med, Kurume, Fukuoka, Japan.
C3 Kurume University; Kurume University
RP Kurume Univ, Sch Med, Dept Med, 67 Asahimachi, Kurume, Fukuoka 8300011, Japan.
EM shoichi@med.kurume-u.ac.jp
OI Matsui, Takanori/0000-0001-9506-7571
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NR 18
TC 21
Z9 26
U1 0
U2 0
PU BIOSCIENCE EDIPRINT INC
PI CAROUGE
PA RUE ALEXANDRE-GAVARD 16, 1227 CAROUGE, SWITZERLAND
SN 0378-6501
J9 DRUG EXP CLIN RES
JI Drug Exp. Clin. Res
PY 2005
VL 31
IS 4
BP 155
EP 159
PG 5
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 971MT
UT WOS:000232389100004
PM 16223205
DA 2025-06-11
ER

PT J
AU Navarro-Ledesma, S
   Hamed-Hamed, D
   Pruimboom, L
AF Navarro-Ledesma, Santiago
   Hamed-Hamed, Dina
   Pruimboom, Leo
TI A new perspective of frozen shoulder pathology; the interplay between
   the brain and the immune system
SO FRONTIERS IN PHYSIOLOGY
LA English
DT Review
DE frozen shoulder (adhesive capsulitis); shoulder pain; shoulder
   condition; autoimmune disorder; endocrinological disease; low grade
   inflammation; psychosocial factors
ID PRIMARY/IDIOPATHIC ADHESIVE CAPSULITIS; METABOLIC SYNDROME;
   RISK-FACTORS; PAIN; INFLAMMATION; ASSOCIATION; PREVALENCE; PATHOGENESIS;
   MECHANISMS; DISABILITY
AB Frozen shoulder (FS), also known as adhesive capsulitis of the shoulder (FS), is a fibrotic inflammatory process of unknown etiology whose main symptoms are pain, stiffness and the loss of joint mobility. These symptoms may be associated with pathologies such as diabetes, Dupuytren's syndrome and the prevalence of today's sedentary lifestyle. This literature review provides an overview of the epidemiology and pathogenesis of this pathology, as well as the mechanisms of lowgrade chronic inflammation and infection, insulin resistance, and omics-science associated with it. We also propose a new hypothesis related to the possibility that the GABAergic system could play a decisive role in the development of frozen shoulder and that therefore diabetes type 1, endocrinological autoimmune disorders and frozen shoulder are connected by the same pathophysiological mechanisms. If that is true, the combined presence of psycho-emotional stress factors and pathogenic immune challenges could be the main causes of frozen shoulder syndrome. Finally, we propose a series of possible intervention strategies based on a multifactorial etiological and mechanistic concept.
C1 [Navarro-Ledesma, Santiago] Univ Granada, Fac Hlth Sci, Dept Phys Therapy, Campus Melilla, Melilla, Spain.
   [Navarro-Ledesma, Santiago; Pruimboom, Leo] Univ Granada, Univ Chair Clin Psychoneuroimmunol, Melilla, Spain.
   [Navarro-Ledesma, Santiago; Pruimboom, Leo] PNI Europe, Melilla, Spain.
   [Hamed-Hamed, Dina] Univ Granada, Fac Hlth Sci, Clin Med & Publ Hlth PhD Program, Granada, Spain.
C3 University of Granada; University of Granada; University of Granada
RP Navarro-Ledesma, S (corresponding author), Univ Granada, Fac Hlth Sci, Dept Phys Therapy, Campus Melilla, Melilla, Spain.; Navarro-Ledesma, S (corresponding author), Univ Granada, Univ Chair Clin Psychoneuroimmunol, Melilla, Spain.; Navarro-Ledesma, S (corresponding author), PNI Europe, Melilla, Spain.
EM snl@ugr.es
RI Navarro-Ledesma, Santiago/K-5660-2017
FU University Chair in Clinical Psychoneuroimmunology, University of
   Granada, Spain
FX The author(s) declare that financial support was received for the
   research, authorship, and/or publication of this article. This study was
   partially funded by University Chair in Clinical Psychoneuroimmunology,
   University of Granada, Spain.
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NR 135
TC 8
Z9 8
U1 1
U2 8
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1664-042X
J9 FRONT PHYSIOL
JI Front. Physiol.
PD MAR 29
PY 2024
VL 15
AR 1248612
DI 10.3389/fphys.2024.1248612
PG 12
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA QJ4H6
UT WOS:001220489400001
PM 38617059
OA Green Published
DA 2025-06-11
ER

PT J
AU Zeinivand, M
   Jamali-Raeufy, N
   Zavvari, F
AF Zeinivand, Motahareh
   Jamali-Raeufy, Nida
   Zavvari, Fahime
TI The beneficial role of Hepcidin peptide inhibitor in improved the
   symptoms of COVID-19 in diabetics: anti-inflammatory and potential
   therapeutic effects
SO JOURNAL OF DIABETES AND METABOLIC DISORDERS
LA English
DT Review
DE Diabetes mellitus; COVID-19; Iron; Antihepcidin agents;
   Hyperferritinemic; Inflammation; Hepcidin peptide
ID MOLECULAR-WEIGHT HEPARIN; SERUM FERRITIN; IRON HOMEOSTASIS; METABOLIC
   SYNDROME; HYPERFERRITINEMIA; OPPORTUNITIES; ASSOCIATION; FERROPTOSIS;
   DALTEPARIN; ENOXAPARIN
AB Coronavirus Disease 2019 (COVID-19) is a recent public health issue worldwide. Also, diabetes is a frequent condition with high mortality. There is a strong relationship between COVID-19 and diabetes. This article analyses the intricate relationship between COVID-19 and hepcidin. Hepcidin increases in aged non-insulin diabetic patients. Hepcidin is the last target treatment of several medications commonly used. Viral diseases, especially SARS-CoV19, can activate the hepcidin pathway leading to an elevation in the iron load. This increased iron is released into the bloodstream and results in cell death through ferroptosis, like free iron. Excess iron has pro-coagulative and toxic effects. Hepcidin overexpression and iron overload are associated with COVID-19 infection and can be considered potential targets for treatment. Several studies have shown dalteparin (anti-Hepcidin) could improve the symptoms of COVID-19 in diabetics by appropriately modulating and decreasing oxidative stress and inflammation. This finding can be leading to enhancing the existing knowledge about Therapeutic measures for reducing Covid-19 impairments in diabetics and is suggested as a possible therapeutic agent in diabetes.
C1 [Zeinivand, Motahareh] Kermanshah Univ Med Sci, Sch Med, Dept Physiol, Kermanshah, Iran.
   [Jamali-Raeufy, Nida; Zavvari, Fahime] Iran Univ Med Sci, Fac Med, Dept Physiol, Tehran, Iran.
C3 Kermanshah University of Medical Sciences; Iran University of Medical
   Sciences
RP Zeinivand, M (corresponding author), Kermanshah Univ Med Sci, Sch Med, Dept Physiol, Kermanshah, Iran.
EM Motahareh.zeinivand@kums.ac.ir
OI zavvari, fahime/0000-0002-3782-9408
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NR 109
TC 8
Z9 9
U1 0
U2 4
PU SPRINGER INT PUBL AG
PI CHAM
PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND
EI 2251-6581
J9 J DIABETES METAB DIS
JI J. Diabetes Metab. Disord.
PD DEC
PY 2022
VL 21
IS 2
BP 1797
EP 1807
DI 10.1007/s40200-022-01053-9
EA JUL 2022
PG 11
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA 6G9RJ
UT WOS:000821357600001
PM 35812243
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Lin, JJ
   Liu, X
   Zhou, YL
   Zhu, BS
   Wang, YX
   Cui, W
   Peng, Y
   Wang, B
   Zhao, C
   Zhao, RQ
AF Lin, Junjie
   Liu, Xu
   Zhou, Yalan
   Zhu, Baishu
   Wang, Yuanxin
   Cui, Wei
   Peng, Yan
   Wang, Bin
   Zhao, Chen
   Zhao, Renqing
TI Molecular Basis of Irisin Regulating the Effects of Exercise on Insulin
   Resistance
SO APPLIED SCIENCES-BASEL
LA English
DT Review
DE insulin resistance; exercise; irisin; muscle; liver; fat; energy
   metabolism
ID ADIPOSE-TISSUE; SKELETAL-MUSCLE; MITOCHONDRIAL BIOGENESIS;
   GENE-EXPRESSION; WEIGHT-LOSS; WHITE FAT; GLUCOSE; OBESITY; MYOKINE;
   PGC-1-ALPHA
AB Insulin resistance is recognized as one major feature of metabolic syndrome, and frequently emerges as a difficult problem encountered during long-term pharmacological treatment of diabetes. Insulin resistance often causes organs or tissues, such as skeletal muscle, adipose, and liver, to become less responsive or resistant to insulin. Exercise can promote the physiological function of those organs and tissues and benefits insulin action via increasing insulin receptor sensitivity, glucose uptake, and mitochondrial function. This is done by decreasing adipose tissue deposition, inflammatory cytokines, and oxidative stress. However, understanding the mechanism that regulates the interaction between exercise and insulin function becomes a challenging task. As a novel myokine, irisin is activated by exercise, released from the muscle, and affects multi-organ functions. Recent evidence indicates that it can promote glucose uptake, improve mitochondrial function, alleviate obesity, and decrease inflammation, as a result leading to the improvement of insulin action. We here will review the current evidence concerning the signaling pathways by which irisin regulates the effect of exercise on the up-regulation of insulin action in humans and animals.
C1 [Lin, Junjie; Zhou, Yalan; Zhu, Baishu; Wang, Yuanxin; Cui, Wei; Peng, Yan; Wang, Bin; Zhao, Chen; Zhao, Renqing] Yangzhou Univ, Coll Phys Educ, Yangzhou 225009, Jiangsu, Peoples R China.
   [Liu, Xu] Hunan Univ, Res Inst Educ Sci, Changsha 410006, Peoples R China.
C3 Yangzhou University; Hunan University
RP Zhao, RQ (corresponding author), Yangzhou Univ, Coll Phys Educ, Yangzhou 225009, Jiangsu, Peoples R China.
EM junjielin2022@163.com; l1282926243@163.com; ylzhou1997@126.com;
   baishuzhu@outlook.com; wangyuanxin880330@163.com;
   cui18752781265@163.com; py1223557545@163.com; bwang1999@126.com;
   zc072866@outlook.com; renqing.zhao@yzu.edu.cn
RI Wang, Bin/O-1322-2015; lin, junjie/HDL-7170-2022
OI Zhao, Renqing/0000-0001-8901-9506; Lin, Junjie/0000-0002-2252-0985
FU Natural Science Foundation of Jiangsu Province [BK20201435]
FX The Natural Science Foundation of Jiangsu Province provided funding for
   this research (BK20201435).
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NR 106
TC 10
Z9 11
U1 0
U2 25
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3417
J9 APPL SCI-BASEL
JI Appl. Sci.-Basel
PD JUN
PY 2022
VL 12
IS 12
AR 5837
DI 10.3390/app12125837
PG 13
WC Chemistry, Multidisciplinary; Engineering, Multidisciplinary; Materials
   Science, Multidisciplinary; Physics, Applied
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Engineering; Materials Science; Physics
GA 2K4XH
UT WOS:000816340200001
OA gold
DA 2025-06-11
ER

PT J
AU Bima, A
   Eldakhakhny, B
   Nuwaylati, D
   Alnami, A
   Ajabnoor, M
   Elsamanoudy, A
AF Bima, Abdulhadi
   Eldakhakhny, Basmah
   Nuwaylati, Dina
   Alnami, Abrar
   Ajabnoor, Mohammed
   Elsamanoudy, Ayman
TI The Interplay of Vitamin D Deficiency and Cellular Senescence in The
   Pathogenesis of Obesity-Related Co-Morbidities
SO NUTRIENTS
LA English
DT Review
DE vitamin D deficiency; cellular senescence; obesity; non-alcoholic fatty
   liver disease; subclinical atherosclerosis
ID FATTY LIVER-DISEASE; SUBCUTANEOUS ADIPOSE-TISSUE; LEUKOCYTE TELOMERE
   LENGTH; SERUM 25-HYDROXYVITAMIN D; FREE-RADICAL THEORY; SUBCLINICAL
   ATHEROSCLEROSIS; INSULIN-RESISTANCE; OXIDATIVE STRESS; ASSOCIATION; RISK
AB This scoping review aims to clarify the interplay between obesity, vitamin D deficiency, cellular senescence, and obesity-related metabolic consequences, mainly subclinical atherosclerosis, and non-alcoholic fatty liver disease (NAFLD). Obesity is a significant global health problem that involves cellular, environmental, behavioral, and genetic elements. The fundamental cause of obesity throughout all life stages is an energy imbalance, and its consequences are countless and, foremost, very common. Obesity has been comprehensively studied in the literature given its association with low serum vitamin D, with many proposed mechanisms linking the two conditions. Moreover, markers of exaggerated cellular senescence have been proven to accumulate in obese individuals. Subclinical atherosclerosis initiates an early stage that ends in serious cardiac events, and obesity, low vitamin D, and senescent cells largely contribute to its associated chronic low-grade inflammation. Furthermore, NAFLD signifies the hepatic manifestation of metabolic syndrome, and studies have highlighted the important role of obesity, vitamin D deficiency, and cellular senescence in its development. Therefore, we outlined the most important mechanisms tying these conditions to one another.
C1 [Bima, Abdulhadi; Eldakhakhny, Basmah; Alnami, Abrar; Ajabnoor, Mohammed; Elsamanoudy, Ayman] King Abdulaziz Univ, Fac Med, Dept Clin Biochem, Jeddah 21465, Saudi Arabia.
   [Nuwaylati, Dina] Univ Jeddah, Fac Med, Dept Clin Biochem, Jeddah 21959, Saudi Arabia.
   [Elsamanoudy, Ayman] Mansoura Univ, Fac Med, Med Biochem & Mol Biol, Mansoura 35516, Egypt.
C3 King Abdulaziz University; University of Jeddah; Egyptian Knowledge Bank
   (EKB); Mansoura University
RP Elsamanoudy, A (corresponding author), King Abdulaziz Univ, Fac Med, Dept Clin Biochem, Jeddah 21465, Saudi Arabia.; Elsamanoudy, A (corresponding author), Mansoura Univ, Fac Med, Med Biochem & Mol Biol, Mansoura 35516, Egypt.
EM dina.nuwaylati@gmail.com
RI ; Elsamanoudy, Ayman/M-6529-2018; Eldakhakhny, Basmah/ABD-6211-2020
OI Nuwaylati, Dena/0000-0003-2547-4248; Elsamanoudy,
   Ayman/0000-0002-8731-6184; Eldakhakhny, Basmah/0000-0002-6962-5848
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NR 147
TC 9
Z9 10
U1 1
U2 13
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD NOV
PY 2021
VL 13
IS 11
AR 4127
DI 10.3390/nu13114127
PG 21
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA XF0MN
UT WOS:000723773600001
PM 34836382
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Zanini, S
   Renzi, S
   Limongi, AR
   Bellavite, P
   Giovinazzo, F
   Bermano, G
AF Zanini, Sara
   Renzi, Serena
   Limongi, Antonina R.
   Bellavite, Paolo
   Giovinazzo, Francesco
   Bermano, Giovanna
TI A review of lifestyle and environment risk factors for pancreatic cancer
SO EUROPEAN JOURNAL OF CANCER
LA English
DT Review
DE Pancreatic cancer; Life style factors; Tobacco smoking; Alcohol intake;
   Red and processed meat; Environmental and synthetic toxins; Obesity;
   Type 2 diabetes; Metabolic syndrome; Infectious diseases
ID HELICOBACTER-PYLORI INFECTION; DOSE-RESPONSE METAANALYSIS; BODY-MASS
   INDEX; NIH-AARP DIET; CIGARETTE-SMOKING; POOLED ANALYSIS; STATIN USE;
   UPDATED METAANALYSIS; MOLECULAR-MECHANISMS; ATROPHIC GASTRITIS
AB Pancreatic cancer (PaCa) is one of the deadliest cancers known and its incidence is increasing in the developed countries. Because of the lack of biomarkers that allow early detection and the tendency of the disease to be asymptomatic, the diagnosis comes often too late for effective surgical or chemotherapy intervention.
   Lifestyle factors, that may cause common genetic modifications occurring in the disease, interfere with pancreatic physiology or function, and play a role in PaCa development, have been of concern recently, since a strategy to prevent this severe cancer is needed.
   This review identifies the latest evidences related to increased risk of developing PaCa due to dietary habits such as high alcohol, fructose and red or processed meat intake, and pathological conditions such as diabetes, obesity and infections in addition to stress and smoking behaviour.
   It aims to highlight the importance of intervening on modifiable risk factors: the action on these factors could prevent a considerable number of new cases of PaCa. (C) 2020 Elsevier Ltd. All rights reserved.
C1 [Zanini, Sara; Renzi, Serena; Bermano, Giovanna] Robert Gordon Univ, Sch Pharm & Life Sci, Ctr Obes Res & Educ CORE, Aberdeen AB10 7GJ, Scotland.
   [Limongi, Antonina R.] Univ Basilicata, Dept Sci, Potenza, Italy.
   [Limongi, Antonina R.] BioInnova Srl, Potenza, Italy.
   [Bellavite, Paolo] Univ Verona, Dept Med, Sect Gen Pathol, Verona, Italy.
   [Giovinazzo, Francesco] Policlin A Gemelli, Liver Transplant Unit, Rome, Italy.
C3 Robert Gordon University; Italfarmaco; University of Basilicata;
   University of Verona; Catholic University of the Sacred Heart; IRCCS
   Policlinico Gemelli
RP Bermano, G (corresponding author), Robert Gordon Univ, Sch Pharm & Life Sci, Ctr Obes Res & Educ CORE, Aberdeen AB10 7GJ, Scotland.
EM g.bermano@rgu.ac.uk
RI Limongi, Antonina Rita/AAZ-9422-2021; RENZI, SERENA/IAT-1873-2023;
   Giovinazzo, Francesco/G-2028-2011
OI RENZI, SERENA/0000-0002-8206-8994; , Antonina Rita
   Limongi/0000-0003-1570-8370; Giovinazzo, Francesco/0000-0002-3392-9292
FU Centre for Obesity Research and Education (CORE), Robert Gordon
   University, Aberdeen, UK
FX This work was supported by the Centre for Obesity Research and Education
   (CORE), Robert Gordon University, Aberdeen, UK.
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NR 161
TC 38
Z9 40
U1 1
U2 22
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 0959-8049
EI 1879-0852
J9 EUR J CANCER
JI Eur. J. Cancer
PD MAR
PY 2021
VL 145
BP 53
EP 70
DI 10.1016/j.ejca.2020.11.040
EA JAN 2021
PG 18
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA QR6BH
UT WOS:000625301200007
PM 33423007
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Hüttl, M
   Markova, I
   Miklankova, D
   Makovicky, P
   Pelikanova, T
   Seda, O
   Sedová, L
   Malinska, H
AF Huettl, Martina
   Markova, Irena
   Miklankova, Denisa
   Makovicky, Pavol
   Pelikanova, Terezie
   Seda, Ondrej
   Sedova, Lucie
   Malinska, Hana
TI Adverse Effects of Methylglyoxal on Transcriptome and Metabolic Changes
   in Visceral Adipose Tissue in a Prediabetic Rat Model
SO ANTIOXIDANTS
LA English
DT Article
DE methylglyoxal; adipose tissue; insulin resistance
ID NECROSIS-FACTOR-ALPHA; DICARBONYL STRESS; INSULIN-RESISTANCE; GLYCATION;
   OBESITY; CELLS
AB Excessive methylglyoxal (MG) production contributes to metabolic and vascular changes by increasing inflammatory processes, disturbing regulatory mechanisms and exacerbating tissue dysfunction. MG accumulation in adipocytes leads to structural and functional changes. We used transcriptome analysis to investigate the effect of MG on metabolic changes in the visceral adipose tissue of hereditary hypetriglyceridaemic rats, a non-obese model of metabolic syndrome. Compared to controls, 4-week intragastric MG administration impaired glucose tolerance (p< 0.05) and increased glycaemia (p< 0.01) and serum levels of MCP-1 and TNF alpha (p< 0.05), but had no effect on serum adiponectin or leptin. Adipose tissue insulin sensitivity and lipolysis were impaired (p< 0.05) in MG-treated rats. In addition, MG reduced the expression of transcription factorNrf2(p< 0.01), which controls antioxidant and lipogenic genes. Increased expression ofMcp-1andTNF alpha(p< 0.05) together with activation of the SAPK/JNK signaling pathway can promote chronic inflammation in adipose tissue. Transcriptome network analysis revealed the over-representation of genes involved in insulin signaling (Irs1, Igf2, Ide), lipid metabolism (Nr1d1, Lpin1, Lrpap1) and angiogenesis (Dusp10, Tp53inp1).
C1 [Huettl, Martina; Markova, Irena; Miklankova, Denisa; Malinska, Hana] Inst Clin & Expt Med, Ctr Expt Med, Prague 14021, Czech Republic.
   [Makovicky, Pavol] J Selye Univ, Fac Educ, Dept Biol, Komarno 94501, Slovakia.
   [Pelikanova, Terezie] Inst Clin & Expt Med, Diabet Ctr, Prague 14021, Czech Republic.
   [Seda, Ondrej; Sedova, Lucie] Charles Univ Prague, Fac Med 1, Inst Biol & Med Genet, Prague 12108, Czech Republic.
   [Seda, Ondrej; Sedova, Lucie] Gen Univ Hosp, Prague 12108, Czech Republic.
C3 Institute for Clinical & Experimental Medicine (IKEM); J. Selye
   University; Institute for Clinical & Experimental Medicine (IKEM);
   Charles University Prague; General University Hospital Prague
RP Malinska, H (corresponding author), Inst Clin & Expt Med, Ctr Expt Med, Prague 14021, Czech Republic.
EM mabw@ikem.cz; irma@ikem.cz; mild@ikem.cz; makovicky.pavol@gmail.com;
   tepe@ikem.cz; ondrej.seda@lfl.cuni.cz; lsedo@lfl.cuni.cz; haml@ikem.cz
RI Sedova, Lucie/D-1089-2017; Seda, Ondrej/A-2058-2008
OI Sedova, Lucie/0000-0003-3783-2946; Markova, Irena/0000-0002-4331-7636;
   Seda, Ondrej/0000-0001-8498-5895; Malinska, Hana/0000-0002-9076-3399;
   Miklankova, Denisa/0000-0002-8771-9338
FU Ministry of Health of the Czech Republic under the conceptual
   development of research organisations programme (Institute for Clinical
   and Experimental Medicine-IKEM) [IN 00023001]; Ministry of Health of the
   Czech Republic under the conceptual development of research
   organisations programme (General University Hospital, Prague) [RVO
   VFN64165]
FX This work was supported by the Ministry of Health of the Czech Republic
   under the conceptual development of research organisations programme
   (Institute for Clinical and Experimental Medicine-IKEM, IN 00023001 and
   General University Hospital, Prague-RVO VFN64165).
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NR 40
TC 9
Z9 9
U1 0
U2 10
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD SEP
PY 2020
VL 9
IS 9
AR 803
DI 10.3390/antiox9090803
PG 15
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA OE9EY
UT WOS:000580825900001
PM 32878255
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Ardalan, MR
   Tabibi, H
   Attari, VE
   Mahdavi, AM
AF Ardalan, Mohammad Reza
   Tabibi, Hadi
   Attari, Vahideh Ebrahimzadeh
   Mahdavi, Aida Malek
TI Nephrotoxic Effect of Aspartame as an Artificial Sweetener A Brief
   Review
SO IRANIAN JOURNAL OF KIDNEY DISEASES
LA English
DT Review
DE artificial sweeteners; aspartame; nephrotoxicity; kidney injury
ID INDUCED OXIDATIVE STRESS; LOW-CALORIE SWEETENERS; GUT MICROBIOME;
   UNITED-STATES; CONSUMPTION; RATS; BRAIN; BEVERAGES; DISEASE; HUMANS
AB Aspartame is one of the most popular artificial sweeteners over the world. Although its consumption is considered to be safe in acceptable daily intake ranges which were set by the United States Food and Drugs Administration and other regulatory agencies, there are lots of controversies regarding its safety nowadays. Some of the recent experimental and epidemiological studies showed that consumption of aspartame may causes some adverse health effects including obesity, metabolic syndrome, and alteration in gut microbiota. Moreover, studies on the nephrotoxic effect of aspartame have increased. A search of several literature databases for publications on adverse effects of aspartame on the kidney function from 1980 to 2016 showed that long-term consumption of aspartame led to a dose-dependent increased production of free radicals in renal tissues as well as kidney injury, based on several studies on animals However, given the lack of clinical data in this area, it is difficult to make a definitive conclusion regarding nephrotoxic effect of aspartame. Overall, consumers should be aware of the potential side effects of aspartame and other artificial sweeteners. At present it may be recommended that only a minimal amount of them would be consumed.
C1 [Ardalan, Mohammad Reza; Attari, Vahideh Ebrahimzadeh] Tabriz Univ Med Sci, Kidney Res Ctr, Tabriz, Iran.
   [Tabibi, Hadi] Natl Nutr & Food Technol Res Inst, Fac Nutr Sci & Food Technol, Dept Human Nutr, Tehran, Iran.
   [Mahdavi, Aida Malek] Tabriz Univ Med Sci, Connect Tissue Dis Res Ctr, Tabriz, Iran.
C3 Tabriz University of Medical Science; Tabriz University of Medical
   Science
RP Attari, VE (corresponding author), Tabriz Univ Med Sci, Kidney Res Ctr, Tabriz, Iran.
EM ebrahimzadehv@tbzmed.ac.ir
RI ardalan, mohammadreza/AAM-1367-2020; Attari, Vahideh/N-2172-2017;
   Mahdavi, Aida/N-3109-2017; Tabibi, Hadi/AHD-6967-2022
OI Ardalan, Mohammadreza/0000-0002-6851-5460; Tabibi,
   Hadi/0000-0001-9094-7772
FU Kidney Research Center, Tabriz University of Medical Sciences (Tabriz,
   Iran)
FX This study was supported by the Kidney Research Center, Tabriz
   University of Medical Sciences (Tabriz, Iran).
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NR 48
TC 18
Z9 20
U1 1
U2 60
PU IRANIAN SOC NEPHROLGY
PI TEHRAN
PA APT 12, NO 63, SHAHEED TOUSI ST, DR GHARIB ST, KESHAVARZ BLVD, TEHRAN,
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SN 1735-8582
EI 1735-8604
J9 IRAN J KIDNEY DIS
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PD SEP
PY 2017
VL 11
IS 5
BP 339
EP 343
PG 5
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA FO7XV
UT WOS:000417093900002
PM 29038387
DA 2025-06-11
ER

PT J
AU Ma, CC
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AF Ma, Claudia C.
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   Joseph, Parveen Nedra
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TI Associations of Objectively Measured and Self-Reported Sleep Duration
   With Carotid Artery Intima Media Thickness Among Police Officers
SO AMERICAN JOURNAL OF INDUSTRIAL MEDICINE
LA English
DT Article
DE carotid artery intima media thickness; occupational epidemiology; sleep
   duration; actigraphy
ID CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; RISK-FACTORS;
   PHYSICAL-ACTIVITY; NATIONAL-HEALTH; SHIFT WORK; POPULATION; MORTALITY;
   EVENTS; STRESS
AB BackgroundWe aimed to examine the association of objectively measured and self-reported sleep duration with carotid artery intima media thickness (IMT) among 257 police officers, a group at high risk for cardiovascular disease (CVD).
   MethodsSleep duration was estimated using actigraphic data and through self-reports. The mean maximum IMT was the average of the largest 12 values scanned bilaterally from three angles of the near and far wall of the common carotid, bulb, and internal carotid artery. Linear and quadratic regression models were used to assess the association of sleep duration with IMT.
   ResultsOfficers who had fewer than 5 or 8hr or more of objectively measured sleep duration had significantly higher maximum IMT values, independent of age. Self-reported sleep duration was not associated with either IMT measure.
   ConclusionAttainment of sufficient sleep duration may be considered as a possible strategy for atherosclerosis prevention among police officers. Am. J. Ind. Med. 56:1341-1351, 2013. Published 2013. This article is a U.S. Government work and is in the public domain in the USA.
C1 [Ma, Claudia C.; Burchfiel, Cecil M.; Charles, Luenda E.; Andrew, Michael E.; Gu, Ja Kook; Joseph, Parveen Nedra; Fekedulegn, Desta; Slaven, James E.; Hartley, Tara A.; Mnatsakanova, Anna] NIOSH, HELD, Ctr Dis Control & Prevent, Morgantown, WV 26505 USA.
   [Dorn, Joan M.; Violanti, John M.] SUNY Buffalo, Dept Social & Prevent Med, Sch Publ Hlth & Hlth Profess, Buffalo, NY 14260 USA.
   [Dorn, Joan M.] Ctr Dis Control & Prevent, Off Noncommunicable Dis, Natl Ctr Chron Dis Prevent & Hlth Promot Injury &, Atlanta, GA USA.
   [Joseph, Parveen Nedra] Univ Chicago, Ctr Comprehens Canc, Epidemiol & Res Recruitment Core, Chicago, IL 60637 USA.
   [Slaven, James E.] Indiana Univ Sch Med, Dept Biostat, Indianapolis, IN 46202 USA.
C3 Centers for Disease Control & Prevention - USA; National Institute for
   Occupational Safety & Health (NIOSH); State University of New York
   (SUNY) System; University at Buffalo, SUNY; Centers for Disease Control
   & Prevention - USA; Robert H. Lurie Comprehensive Cancer Center;
   University of Chicago; Indiana University System; Indiana University
   Bloomington
RP Ma, CC (corresponding author), NIOSH, HELD, MS L-4050,1095 Willowdale Rd, Morgantown, WV 26505 USA.
EM iia4@cdc.gov
RI Charles, Luenda/H-6008-2011
OI Ma, Claudia C./0000-0001-5639-5978; /0000-0002-0245-5899; Joseph,
   Parveen/0000-0001-5635-085X
FU National Institute for Occupational Safety and Health (NIOSH)
   [200-2003-01580]
FX Contract grant sponsor: National Institute for Occupational Safety and
   Health (NIOSH); Contract grant number: 200-2003-01580.
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NR 60
TC 24
Z9 26
U1 0
U2 8
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0271-3586
EI 1097-0274
J9 AM J IND MED
JI Am. J. Ind. Med.
PD NOV
PY 2013
VL 56
IS 11
BP 1341
EP 1351
DI 10.1002/ajim.22236
PG 11
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA 230QH
UT WOS:000325356700010
PM 24038303
OA Green Published, Green Accepted, Green Submitted
DA 2025-06-11
ER

PT J
AU Aranda, JF
   Madrigal-Matute, J
   Rotllan, N
   Fernández-Hernando, C
AF Aranda, Juan F.
   Madrigal-Matute, Julio
   Rotllan, Noemi
   Fernandez-Hernando, Carlos
TI MicroRNA modulation of lipid metabolism and oxidative stress in
   cardiometabolic diseases
SO FREE RADICAL BIOLOGY AND MEDICINE
LA English
DT Review
DE MiRNAs; Lipid metabolism; Atherosclerosis; Free radicals
ID HIGH-DENSITY-LIPOPROTEIN; SMOOTH-MUSCLE-CELLS; CIRCULATING MICRORNAS;
   SCAVENGER RECEPTOR; ATHEROSCLEROTIC PLAQUE; INFLAMMATORY RESPONSE;
   GENE-EXPRESSION; CLASS-B; SR-BI; CHOLESTEROL
AB Atherosclerosis Free radicals The regulation of the metabolism of cholesterol has been one of the most studied biological processes since its first isolation from gallstones in 1784. High levels of plasma low-density lipoprotein (LDL) cholesterol and reduced levels of plasma high-density lipoprotein (HDL) cholesterol are widely recognized as major risk factors of cardiovascular disease. An imbalance in the production of reactive oxygen species can oxidize LDL particles, increasing the levels of the highly proatherogenic oxidized LDL. Furthermore, under pathological scenarios, numerous molecules can function as pro-oxidants, such as iron or (high levels of) glucose. In addition to the classical mechanisms regulating lipid homeostasis, recent studies have demonstrated the important role of microRNAs (miRNAs) as regulators of lipoprotein metabolism, oxidative derivatives of lipoprotein, and redox balance. Here, we summarize recent findings in the field, highlighting the contributions of some miRNAs to lipid- and oxidative-associated pathologies. We also discuss how therapeutic intervention of miRNAs may be a promising strategy to decrease LDL, increase HDL, and ameliorate lipid- and oxidative-related disorders, including atherosclerosis, nonalcoholic fatty liver disease, and metabolic syndrome. (c) 2013 Elsevier Inc. All rights reserved.
C1 [Fernandez-Hernando, Carlos] NYU, Sch Med, Dept Med, New York, NY 10016 USA.
   NYU, Sch Med, Dept Cell Biol, Leon H Charney Div Cardiol, New York, NY 10016 USA.
   NYU, Sch Med, Marc & Ruti Bell Vasc Biol & Dis Program, New York, NY 10016 USA.
C3 New York University; New York University; New York University
RP Fernández-Hernando, C (corresponding author), NYU, Sch Med, Dept Med, New York, NY 10016 USA.
EM carlos.fernandez-hernando@nyumc.org
RI Rotllan Vila, Noemi/AAQ-8050-2020; Aranda Gomez, Juan
   Francisco/S-6388-2018; Rotllan, Noemi/P-1375-2014
OI Aranda Gomez, Juan Francisco/0000-0002-5598-2465; Madrigal-Matute,
   Julio/0000-0002-0894-5450; Rotllan, Noemi/0000-0002-0587-8045
FU National Institutes of Health [R01HL107953, R01HL106063]; Ministerio de
   Educacion
FX This work was supported by grants from the National Institutes of Health
   (R01HL107953 and R01HL106063 to C.F.-H.). N.R. is supported by the
   Ministerio de Educacion (Programa Nacional de Movilidad de Recursos
   Humanos del Plan Nacional de I-D+i 2008-2011). Figures were produced
   using Servier Medical Art (www.servier.com). C.F.-H has patents on the
   use of miRNA-33 inhibitors.
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NR 105
TC 51
Z9 53
U1 0
U2 46
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0891-5849
EI 1873-4596
J9 FREE RADICAL BIO MED
JI Free Radic. Biol. Med.
PD SEP
PY 2013
VL 64
SI SI
BP 31
EP 39
DI 10.1016/j.freeradbiomed.2013.07.014
PG 9
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 217JN
UT WOS:000324355900005
PM 23871755
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Alufer, L
   Tsaban, G
   Rinott, E
   Kaplan, A
   Meir, AY
   Zelicha, H
   Ceglarek, U
   Isermann, B
   Blueher, M
   Stumvoll, M
   Stampfer, MJ
   Shai, I
AF Alufer, Liav
   Tsaban, Gal
   Rinott, Ehud
   Kaplan, Alon
   Meir, Anat Yaskolka
   Zelicha, Hila
   Ceglarek, Uta
   Isermann, Berend
   Blueher, Matthias
   Stumvoll, Michael
   Stampfer, Meir J.
   Shai, Iris
TI Long-term green-Mediterranean diet may favor fasting morning cortisol
   stress hormone; the DIRECT-PLUS clinical trial
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Article
DE fasting plasma cortisol; lifestyle intervention; mediterranean diet;
   weight loss; insulin resistance; cardiometabolic health
ID CIRCULATING LEVELS; PLASMA-CORTISOL; FOOD-FREQUENCY; RISK;
   GLUCOCORTICOIDS; POLYPHENOLS; ALTERS; IMPACT; ADULTS
AB Background: Fasting morning cortisol (FMC) stress hormone levels, are suggested to reflect increased cardiometabolic risk. Acute response to weight loss diet could elevate FMC. Richer Polyphenols and lower carbohydrates diets could favor FMC levels. We aimed to explore the effect of long-term high polyphenol Mediterranean diet (green-MED) on FMC and its relation to metabolic health.Methods: We randomized 294 participants into one of three dietary interventions for 18-months: healthy dietary guidelines (HDG), Mediterranean (MED) diet, and Green-MED diet. Both MED diets were similarly hypocaloric and lower in carbohydrates and included walnuts (28 g/day). The high-polyphenols/low-meat Green-MED group further included green tea (3-4 cups/day) and a Wolffia-globosa Mankai plant 1-cup green shakeFMC was obtained between 07:00-07:30AM at baseline, six, and eighteen-months.Participants (age=51.1years, 88% men) had a mean BMI of 31.3kg/m(2), FMC=304.07nmol\L, and glycated-hemoglobin-A1c (HbA1c)=5.5%; 11% had type 2 diabetes and 38% were prediabetes. Baseline FMC was higher among men (308.6 +/- 90.05nmol\L) than women (269.6 +/- 83.9nmol\L;p=0.02). Higher baseline FMC was directly associated with age, dysglycemia, MRI-assessed visceral adiposity, fasting plasma glucose (FPG), high-sensitivity C-reactive-protein (hsCRP), testosterone, Progesterone and TSH levels (p <= 0.05 for all). The 18-month retention was 89%. After 6 months, there were no significant changes in FMC among all intervention groups. However, after 18-months, both MED groups significantly reduced FMC (MED=-1.6%[-21.45 nmol/L]; Green-MED=-1.8%[-26.67 nmol/L]; p<0.05 vs. baseline), as opposed to HDG dieters (+4%[-12 nmol/L], p=0.28 vs. baseline), whereas Green-MED diet FMC change was significant as compared to HDG diet group (p=0.048 multivariable models). Overall, 18-month decrease in FMC levels was associated with favorable changes in FPG, HbA1c, hsCRP, TSH, testosterone and MRI-assessed hepatosteatosis, and with unfavorable changes of HDLc (p<0.05 for all, weight loss adjusted, multivariable models).Conclusion: Long-term adherence to MED diets, and mainly green-MED/high polyphenols diet, may lower FMC, stress hormone, levels,. Lifestyle-induced FMC decrease may have potential benefits related to cardiometabolic health, irrespective of weight loss.
C1 [Alufer, Liav; Tsaban, Gal; Kaplan, Alon; Meir, Anat Yaskolka; Zelicha, Hila; Shai, Iris] Ben Gurion Univ Negev, Fac Hlth Sci, Beer Sheva, Israel.
   [Rinott, Ehud] Hebrew Univ Jerusalem, Dept Med, Jerusalem, Israel.
   [Rinott, Ehud] Hadassah Med Ctr, Jerusalem, Israel.
   [Ceglarek, Uta; Isermann, Berend; Blueher, Matthias; Stumvoll, Michael; Shai, Iris] Univ Leipzig, Dept Med, Leipzig, Germany.
   [Blueher, Matthias; Stumvoll, Michael] Univ Leipzig, Helmholtz Zentrum Munchen, Helmholtz Inst Metab, Helmholtz Zentrum Munchen,Obes & Vasc Res HI MAG, Leipzig, Germany.
   [Blueher, Matthias; Stumvoll, Michael] Univ Hosp Leipzig, Leipzig, Germany.
   [Stampfer, Meir J.; Shai, Iris] Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA.
   [Stampfer, Meir J.] Harvard Med Sch, Dept Med, Channing Div Network Med, Boston, MA USA.
   [Stampfer, Meir J.] Brigham & Womens Hosp, Boston, MA USA.
C3 Ben-Gurion University of the Negev; Hebrew University of Jerusalem;
   Hebrew University of Jerusalem; Hadassah University Hospital; Hadassah
   University Medical Center; Leipzig University; Helmholtz Association;
   Helmholtz-Center Munich - German Research Center for Environmental
   Health; Leipzig University; Leipzig University; Harvard University;
   Harvard T.H. Chan School of Public Health; Harvard University; Harvard
   Medical School; Harvard University; Harvard University Medical
   Affiliates; Brigham & Women's Hospital
RP Shai, I (corresponding author), Ben Gurion Univ Negev, Fac Hlth Sci, Beer Sheva, Israel.
EM irish@bgu.ac.il
RI Rinott, Ehud/KRO-7063-2024; SHAI, IRIS/HJO-8533-2023; Ceglarek,
   Uta/GOE-5561-2022; Stumvoll, Michael/ABE-1121-2021; Meir,
   Anat/AAK-7469-2021
FU Deutsche Forschungsgemeinschaft10.13039/501100001659; Soroka University
   Medical Center
FX We thank the DIRECT-PLUS trial participants. We thank Ilan Shelef from
   Soroka University Medical Center and Eyal Goshen, Efran Popkin, Avi Ben
   Shabat, and Benjamin Sarusi from the Nuclear Research Center Negev for
   their valuable contributions.
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NR 39
TC 3
Z9 3
U1 3
U2 13
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD NOV 14
PY 2023
VL 14
AR 1243910
DI 10.3389/fendo.2023.1243910
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA Z8ZM9
UT WOS:001114902100001
PM 38034010
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Sanchis, P
   Calvo, P
   Pujol, A
   Rivera, R
   Berga, F
   Fortuny, R
   Costa-Bauza, A
   Grases, F
   Masmiquel, L
AF Sanchis, Pilar
   Calvo, Paula
   Pujol, Antelm
   Rivera, Rosmeri
   Berga, Francisco
   Fortuny, Regina
   Costa-Bauza, Antonia
   Grases, Felix
   Masmiquel, Luis
TI Daily phytate intake increases adiponectin levels among patients with
   diabetes type 2: a randomized crossover trial
SO NUTRITION & DIABETES
LA English
DT Article
ID C-REACTIVE PROTEIN; PHYTIC ACID; INSULIN-RESISTANCE; ADIPOSE-TISSUE;
   METABOLIC SYNDROME; OXIDATIVE STRESS; SODIUM PHYTATE; INFLAMMATION;
   SENSITIVITY; ABSORPTION
AB AimAdiponectin, a major adipokine secreted by adipose tissue, has been shown to improve insulin sensitivity. Myo-inositol hexaphosphate (phytate; InsP6) is a natural compound that is abundant in cereals, legumes, and nuts that has demonstrated to have different beneficial properties in patients with diabetes type 2.MethodsWe performed a randomized crossover trial to investigate the impact of daily consumption of InsP6 on serum levels of adiponectin, TNF-alpha, IL-6, and IL-1beta in patients with type 2 diabetes mellitus (T2DM; n = 39). Thus, we measure serum levels of these inflammatory markers, classic vascular risk factors, and urinary InsP6 at baseline and at the end of the intervention period.ResultsPatients who consumed InsP6 supplements for 3 months had higher levels of adiponectin and lower HbA1c than those who did not consume InsP6. No differences were found in TNF-alpha, IL-6, and IL-1beta.ConclusionThis is the first report to show that consumption of InsP6 increases plasma adiponectin concentration in patients with T2DM. Consequently, our findings indicate that following a phytate-rich diet has beneficial effects on adiponectin and HbA1c concentrations and it could help to prevent or minimize diabetic-related complications.
C1 [Sanchis, Pilar; Calvo, Paula; Berga, Francisco; Costa-Bauza, Antonia; Grases, Felix] Univ Balearic Isl, Lab Renal Lithiasis Res, Dept Chem, Inst Hlth Sci Res IUN IdISBa, Palma De Mallorca 07122, Spain.
   [Sanchis, Pilar; Calvo, Paula; Berga, Francisco; Costa-Bauza, Antonia; Grases, Felix] Inst Salud Carlos III, CIBER Fisiopatol Obes & Nutr CIBERObn, Madrid, Spain.
   [Sanchis, Pilar; Pujol, Antelm; Rivera, Rosmeri; Fortuny, Regina; Masmiquel, Luis] Son Llatzer Univ Hosp, Vasc & Metab Dis Res Grp, Endocrinol Dept, Inst Hlth Sci Res IdISBa, Palma De Mallorca 07198, Spain.
C3 Universitat de les Illes Balears; Instituto de Salud Carlos III; CIBER -
   Centro de Investigacion Biomedica en Red; CIBEROBN; Hospital
   Universitari Son Llatzer
RP Sanchis, P (corresponding author), Univ Balearic Isl, Lab Renal Lithiasis Res, Dept Chem, Inst Hlth Sci Res IUN IdISBa, Palma De Mallorca 07122, Spain.; Sanchis, P (corresponding author), Inst Salud Carlos III, CIBER Fisiopatol Obes & Nutr CIBERObn, Madrid, Spain.; Sanchis, P; Masmiquel, L (corresponding author), Son Llatzer Univ Hosp, Vasc & Metab Dis Res Grp, Endocrinol Dept, Inst Hlth Sci Res IdISBa, Palma De Mallorca 07198, Spain.
EM pilar.sanchis@uib.es; lmasmiquel@hsll.es
RI Sanchis, Pilar/AAH-4684-2020; Calvó Garcia, Paula/G-2632-2019
OI Rivera Irigoin, Rosmeri/0009-0009-6917-4897; Sanchis,
   Pilar/0000-0001-8565-1811; MASMIQUEL, LUIS/0000-0002-6549-5652; Pujol,
   Antelm/0000-0002-4579-4620
FU Conselleria d'Educacio, Universitat i Recerca of the Government of the
   Balearic Islands [FPI_003_2020]
FX PC is grateful to the Conselleria d'Educacio, Universitat i Recerca of
   the Government of the Balearic Islands for the fellowship FPI_003_2020.
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NR 49
TC 15
Z9 15
U1 1
U2 8
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 2044-4052
J9 NUTR DIABETES
JI Nutr. Diabetes
PD FEB 28
PY 2023
VL 13
IS 1
AR 2
DI 10.1038/s41387-023-00231-9
PG 9
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 9K8BY
UT WOS:000941088600001
PM 36854678
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Kobori, A
   Miyashita, M
   Miyano, Y
   Suzuki, K
   Toriumi, K
   Niizato, K
   Oshima, K
   Imai, A
   Nagase, Y
   Yoshikawa, A
   Horiuchi, Y
   Yamasaki, S
   Nishida, A
   Usami, S
   Takizawa, S
   Itokawa, M
   Arai, H
   Arai, M
AF Kobori, Akiko
   Miyashita, Mitsuhiro
   Miyano, Yasuhiro
   Suzuki, Kazuhiro
   Toriumi, Kazuya
   Niizato, Kazuhiro
   Oshima, Kenichi
   Imai, Atsushi
   Nagase, Yukihiro
   Yoshikawa, Akane
   Horiuchi, Yasue
   Yamasaki, Syudo
   Nishida, Atsushi
   Usami, Satoshi
   Takizawa, Shunya
   Itokawa, Masanari
   Arai, Heii
   Arai, Makoto
TI Advanced glycation end products and cognitive impairment in
   schizophrenia
SO PLOS ONE
LA English
DT Article
ID ENHANCED CARBONYL STRESS; WORK OUTCOMES; SUPPORTED EMPLOYMENT; METABOLIC
   SYNDROME; NEGATIVE SYMPTOMS; MENTAL-ILLNESS; REMEDIATION; METAANALYSIS;
   ASSOCIATION; SUBPOPULATION
AB Advanced glycation end products play a key role in the pathophysiology of schizophrenia. Cognitive impairment is one of the central features of schizophrenia; however, the association between advanced glycation end products and cognitive impairment remains unknown. This study investigated whether advanced glycation end products affect the cognitive domain in patients with schizophrenia. A total of 58 patients with chronic schizophrenia were included in this cross-sectional study. Plasma advanced glycation end products were measured using high-performance liquid chromatography (HPLC). Neuropsychological and cognitive functions were assessed using the Wechsler Adult Intelligence Scale, Third Version, and the Wisconsin Card Sorting Test Keio-FS version. Multiple regression analysis adjusted for age, sex, body mass index, educational years, daily dose of antipsychotics, and psychotic symptoms revealed that processing speed was significantly associated with plasma pentosidine, a representative advanced glycation end product (standardized beta = -0.425; p = 0.009). Processing speed is the cognitive domain affected by advanced glycation end products. Considering preceding evidence that impaired processing speed is related to poor functional outcome, interventions targeted at reducing advanced glycation end products may contribute to promoting recovery of patients with schizophrenia as well as cognitive function improvement.
C1 [Kobori, Akiko; Miyashita, Mitsuhiro; Miyano, Yasuhiro; Suzuki, Kazuhiro; Toriumi, Kazuya; Yoshikawa, Akane; Horiuchi, Yasue; Itokawa, Masanari; Arai, Makoto] Tokyo Metropolitan Inst Med Sci, Schizophrenia Res Project, Dept Psychiat & Behav Sci, Setagaya Ku, Tokyo, Japan.
   [Kobori, Akiko; Arai, Heii] Juntendo Univ, Grad Sch Med, Dept Psychiat & Behav Sci, Bunkyo Ku, Tokyo, Japan.
   [Miyashita, Mitsuhiro; Miyano, Yasuhiro; Niizato, Kazuhiro; Oshima, Kenichi; Imai, Atsushi; Itokawa, Masanari] Tokyo Metropolitan Matsuzawa Hosp, Dept Psychiat, Setagaya Ku, Tokyo, Japan.
   [Miyashita, Mitsuhiro; Suzuki, Kazuhiro; Nagase, Yukihiro] Takatsuki Hosp, Dept Psychiat, Hachioji, Tokyo, Japan.
   [Yamasaki, Syudo; Nishida, Atsushi] Tokyo Metropolitan Inst Med Sci, Res Ctr Social Sci & Med, Setagaya Ku, Tokyo, Japan.
   [Usami, Satoshi] Univ Tokyo, Grad Sch Educ, Bunkyo Ku, Tokyo, Japan.
   [Takizawa, Shunya] Tokai Univ, Sch Med, Dept Internal Med, Div Neurol, Isehara, Kanagawa, Japan.
C3 Tokyo Metropolitan Institute of Medical Science; Juntendo University;
   Tokyo Metropolitan Institute of Medical Science; University of Tokyo;
   Tokai University
RP Arai, M (corresponding author), Tokyo Metropolitan Inst Med Sci, Schizophrenia Res Project, Dept Psychiat & Behav Sci, Setagaya Ku, Tokyo, Japan.
EM arai-mk@igakuken.or.jp
RI Suzuki, Kazuhiro/JUF-6637-2023; Toriumi, Kazuya/N-2246-2018; Andoh,
   Akira/AAB-9303-2022; Horiuchi, Yasue/ABC-6248-2021; usami,
   satoshi/AGN-5842-2022
OI Yamasaki, Syudo/0000-0002-9016-6404; Suzuki,
   Kazuhiro/0000-0002-0038-4329; Toriumi, Kazuya/0000-0002-8593-3269;
   Takizawa, Shunya/0000-0002-4567-6384
FU Japan Society for the Promotion of Science (JSPS) KAKENHI [15K21648,
   18K07579, 16H05380, 17H05930, 19H04887, 20H03608]; Japan Agency for
   Medical Research and Development (AMED) [JP20dm0107088]; Uehara Memorial
   Foundation; SENSHIN Medical Research Foundation; Sumitomo Foundation;
   Grants-in-Aid for Scientific Research [19H04887, 20H03608, 17H05930,
   16H05380, 15K21648, 18K07579] Funding Source: KAKEN
FX This work was supported by the Japan Society for the Promotion of
   Science (JSPS) KAKENHI (15K21648 to AK; 18K07579 to MM; 16H05380,
   17H05930, 19H04887, and 20H03608 to MA); the Japan Agency for Medical
   Research and Development (AMED) (JP20dm0107088 to MI); the Uehara
   Memorial Foundation (to MA); SENSHIN Medical Research Foundation (to
   MA); and the Sumitomo Foundation (to MA). The JSPS, AMED, the Uehara
   Foundation, and the Sumitomo Foundation had no role in the design and
   conduct of the study; collection, management, analysis, and
   interpretation of the data; preparation, review, or approval of the
   manuscript; or decision to submit the manuscript for publication.
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NR 44
TC 8
Z9 9
U1 0
U2 7
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAY 26
PY 2021
VL 16
IS 5
AR e0251283
DI 10.1371/journal.pone.0251283
PG 9
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Science & Technology - Other Topics
GA SW6OP
UT WOS:000664633500017
PM 34038433
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Jayachandran, M
   Qu, S
AF Jayachandran, Muthukumaran
   Qu, Shen
TI Harnessing hyperuricemia to atherosclerosis and understanding its
   mechanistic dependence
SO MEDICINAL RESEARCH REVIEWS
LA English
DT Review
DE atherosclerosis; hyperuricemia; inflammation; obesity; xanthine oxidase
ID SERUM URIC-ACID; SMOOTH-MUSCLE-CELLS; ENDOTHELIAL DYSFUNCTION; METABOLIC
   SYNDROME; OXIDATIVE STRESS; CAROTID ATHEROSCLEROSIS; XANTHINE
   OXIDOREDUCTASE; ASSOCIATION; CHILDREN; INFLAMMATION
AB Atherosclerosis is regarded as the disease of the arterial vasculature. The main characteristics of atherosclerosis are the abnormal accumulation of lipids, increased inflammatory cells, matrix deposits, and proliferation of smooth muscle cells. Diabetes mellitus, obesity, and hyperlipidemia are the most studied risk factors of atherosclerosis. One least studied risk factor is the uric acid (UA), a high UA in circulation is interlinked with many pathological processes. Several epidemiological studies suggest elevated UA levels as an essential biomarker in the forecast of several cardiovascular diseases. Available evidence claims that UA upholds the atherosclerosis process via disturbing lipid metabolism, reducing the nitric oxide synthesis in endothelial cells, promoting the proliferation of vascular smooth muscle cells, and overwhelms inflammation. In endothelial dysfunction and coronary artery lesions, UA is considered as an independent predictor. The updated studies on the involvement of hyperuricemia in atherosclerosis prove that treatment with xanthine oxidase (XO) inhibitors not just benefits the treatment of hyperuricemia but also reduces the burden of atherosclerosis to a greater extent. In this review, we highlight how the hyperuricemia affects vascular integrity, causes atherosclerosis, and the mechanism of action of XO inhibitors on atherosclerosis.
C1 [Jayachandran, Muthukumaran; Qu, Shen] Tongji Univ, Shanghai Tenth Peoples Hosp, Sch Med, Dept Endocrinol & Metab, 301 Middle Yanchang Rd, Shanghai 200072, Peoples R China.
C3 Tongji University
RP Qu, S (corresponding author), Tongji Univ, Shanghai Tenth Peoples Hosp, Sch Med, Dept Endocrinol & Metab, 301 Middle Yanchang Rd, Shanghai 200072, Peoples R China.
EM qushencn@hotmail.com
RI Jayachandran, Muthukumaran/AET-2681-2022; Qu, Shen/B-3405-2014
OI Qu, Shen/0000-0003-0811-7070; Jayachandran,
   Muthukumaran/0000-0001-5264-982X
FU National Key R&D Program of China [2018YFC1314101, 2016YFC1305600];
   National Natural Science Foundation of China [81970677]; Fundamental
   Research Funds for the Central Universities of Tongji University
   [22120190210]; Shanghai Committee of Science and Technology, China
   [19DZ1910200, 18411951803, 17DZ1910603]
FX National Key R&D Program of China, Grant/Award Numbers: 2018YFC1314101,
   2016YFC1305600; National Natural Science Foundation of China,
   Grant/Award Number: 81970677; Fundamental Research Funds for the Central
   Universities of Tongji University, Grant/Award Number: 22120190210;
   Shanghai Committee of Science and Technology, China, Grant/Award
   Numbers: 19DZ1910200, 18411951803, 17DZ1910603
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NR 79
TC 56
Z9 66
U1 2
U2 33
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0198-6325
EI 1098-1128
J9 MED RES REV
JI Med. Res. Rev.
PD JAN
PY 2021
VL 41
IS 1
BP 616
EP 629
DI 10.1002/med.21742
EA OCT 2020
PG 14
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA PE3BJ
UT WOS:000579736900001
PM 33084092
DA 2025-06-11
ER

PT J
AU Chakrabarti, S
   Jahandideh, F
   Davidge, ST
   Wu, JP
AF Chakrabarti, Subhadeep
   Jahandideh, Forough
   Davidge, Sandra T.
   Wu, Jianping
TI Milk-Derived Tripeptides IPP (Ile-Pro-Pro) and VPP (Val-Pro-Pro) Enhance
   Insulin Sensitivity and Prevent Insulin Resistance in 3T3-F442A
   Preadipocytes
SO JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
LA English
DT Article
DE IPP; VPP; lactotripeptides; insulin resistance; adipocyte
ID ADIPOSE-TISSUE INFLAMMATION; RENIN-ANGIOTENSIN SYSTEM; METABOLIC
   SYNDROME; BLOOD-PRESSURE; ADIPOCYTE DIFFERENTIATION; HYPERTENSIVE
   SUBJECTS; MOLECULAR-MECHANISMS; OXIDATIVE STRESS; KINASE-ACTIVITY;
   CELL-VOLUME
AB There is great interest in developing naturally derived compounds, especially bioactive peptides with potential insulin sensitizing effects and/or preventing insulin resistance. Previously, we showed adipogenic and insulin mimetic actions of IPP (Ile-Pro-Pro) and VPP (Val-Pro-Pro), the milk-derived tripeptides on cultured preadipocytes, in addition to their previously characterized antihypertensive and anti-inflammatory functions. However, the effect of these peptides on insulin signaling is not known. Therefore, we examined IPP and VPP effects on insulin signaling in preadipocytes, a well-established model for studying insulin signaling. Our results suggested both peptides enhanced insulin signaling and contributed toward the prevention of insulin resistance in the presence of tumor necrosis factor (TNF). Inhibition of inflammatory mediator NF-kB under TNF stimulation was a likely contributor to the prevention of insulin resistance. VPP further enhanced the expression of glucose transporter 4 (GLUT4) in adipocytes and restored glucose uptake in TNF-treated adipocytes. Our data suggested the potential of these peptides in the management of conditions associated with impairments in insulin signaling.
C1 [Chakrabarti, Subhadeep; Jahandideh, Forough; Wu, Jianping] Univ Alberta, Dept Agr Food & Nutr Sci, Edmonton, AB T6G 2P5, Canada.
   [Chakrabarti, Subhadeep; Jahandideh, Forough; Davidge, Sandra T.; Wu, Jianping] Univ Alberta, Cardiovasc Res Ctr, Edmonton, AB T6G 2P5, Canada.
   [Davidge, Sandra T.] Univ Alberta, Dept Obstet & Gynecol, Edmonton, AB T6G 2P5, Canada.
   [Davidge, Sandra T.] Univ Alberta, Dept Physiol, Edmonton, AB T6G 2P5, Canada.
   [Davidge, Sandra T.] Univ Alberta, Women & Childrens Hlth Res Inst, Edmonton, AB T6G 2P5, Canada.
C3 University of Alberta; University of Alberta; University of Alberta;
   University of Alberta; University of Alberta
RP Wu, JP (corresponding author), Univ Alberta, Dept Agr Food & Nutr Sci, Ag For Ctr 4 10, Edmonton, AB T6G 2P5, Canada.
EM jwu3@ualberta.ca
RI Chakrabarti, Subhadeep/AAD-1078-2022; Wu, Jianping/H-9150-2012;
   Jahandideh, Forough/M-4648-2019
OI Jahandideh, Forough/0000-0001-9731-0854; Davidge,
   Sandra/0000-0002-5559-4905; Wu, Jianping/0000-0003-2574-5191
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NR 49
TC 32
Z9 33
U1 1
U2 37
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0021-8561
EI 1520-5118
J9 J AGR FOOD CHEM
JI J. Agric. Food Chem.
PD OCT 3
PY 2018
VL 66
IS 39
BP 10179
EP 10187
DI 10.1021/acs.jafc.8b02051
PG 9
WC Agriculture, Multidisciplinary; Chemistry, Applied; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture; Chemistry; Food Science & Technology
GA GW4VS
UT WOS:000446923600008
PM 30160110
DA 2025-06-11
ER

PT J
AU Azuma, K
   Ifuku, S
AF Azuma, Kazuo
   Ifuku, Shinsuke
TI Nanofibers based on chitin: a new functional food
SO PURE AND APPLIED CHEMISTRY
LA English
DT Article
DE chitin; chitin nanofibrils; EUCHIS-12; functional foods; ICCC-13;
   inflammatory bowel disease; leptin; nuclear factor-kappa B; obesity;
   surface-deacetylated chitin nanofibrils
ID INFLAMMATORY-BOWEL-DISEASE; ORALLY-ADMINISTERED GLUCOSAMINE; METABOLIC
   SYNDROME; ALPHA-CHITIN; OXIDATIVE STRESS; BETA-CHITIN; UNIFORM WIDTH;
   INSULIN-RESISTANCE; POLYMER NANOFIBERS; EXPERIMENTAL-MODEL
AB Chitin (beta-(1-4)-poly-N-acetyl-D-glucosamine) is widely distributed in nature. A method for the preparation of chitin nanofibers (CNFs) is reported. CNFs are considered to have several potential applications because they have useful properties such as high specific surface area and porosity. More recently, beneficial effects of CNF as functional foods were reported. First, the anti-inflammatory effect of oral administration of chitin CNFs was demonstrated in a mouse model of inflammatory bowel disease (IBD). It was found that CNFs improved clinical symptoms and suppressed IBD. CNFs decreased the areas with nuclear factor-kappa B (NF-kappa B) staining in colon tissue. Second, the anti-obesity effects of surface-deacetylated chitin nanofibers (SDACNF) in a mouse model of high-fat diet-induced obesity was evaluated. SDACNFs suppressed the increase in body weight produced by the high-fat diet; however, CNFs did not suppress such weight gain. SDACNFs decreased serum levels of leptin. These results suggest that CNF and SDACNF are promising functional foods for patients with IBD or obesity.
C1 [Azuma, Kazuo] Tottori Univ, Dept Vet Clin Med, Tottori 6808553, Japan.
   [Ifuku, Shinsuke] Tottori Univ, Grad Sch Engn, Tottori 6808552, Japan.
C3 Tottori University; Tottori University
RP Azuma, K (corresponding author), Tottori Univ, Dept Vet Clin Med, Tottori 6808553, Japan.
EM kazu-azuma@muses.tottori-u.ac.jp
RI Ifuku, Shinsuke/JOZ-4444-2023
OI Ifuku, Shinsuke/0009-0006-2948-5234
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NR 110
TC 6
Z9 6
U1 3
U2 32
PU WALTER DE GRUYTER GMBH
PI BERLIN
PA GENTHINER STRASSE 13, D-10785 BERLIN, GERMANY
SN 0033-4545
EI 1365-3075
J9 PURE APPL CHEM
JI Pure Appl. Chem.
PD JUN
PY 2016
VL 88
IS 6
BP 605
EP 619
DI 10.1515/pac-2016-0504
PG 15
WC Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry
GA EB2KI
UT WOS:000387188500005
OA hybrid
DA 2025-06-11
ER

PT J
AU Sharma, S
   Eghbali, M
AF Sharma, Salil
   Eghbali, Mansoureh
TI Influence of sex differences on microRNA gene regulation in disease
SO BIOLOGY OF SEX DIFFERENCES
LA English
DT Review
ID EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; GENDER-DIFFERENCES;
   MESSENGER-RNA; POSTTRANSCRIPTIONAL REGULATION; HORMONAL-REGULATION;
   ALZHEIMERS-DISEASE; METABOLIC SYNDROME; PRENATAL STRESS; X-CHROMOSOME;
   NITRIC-OXIDE
AB Sexual dimorphism is observed in most human diseases. The difference in the physiology and genetics between sexes can contribute tremendously to the disease prevalence, severity, and outcome. Both hormonal and genetic differences between males and females can lead to differences in gene expression patterns that can influence disease risk and course. MicroRNAs have emerged as potential regulatory molecules in all organisms. They can have a broad effect on every aspect of physiology, including embryogenesis, metabolism, and growth and development. Numerous microRNAs have been identified and elucidated to play a key role in cardiovascular diseases, as well as in neurological and autoimmune disorders. This is especially important as microRNA-based tools can be exploited as beneficial therapies for disease treatment and prevention. Sex steroid hormones as well as X-linked genes can have a considerable influence on the regulation of microRNAs. However, there are very few studies highlighting the role of microRNAs in sex biased diseases. This review attempts to summarize differentially regulated microRNAs in males versus females in different diseases and calls for more attention in this underexplored area that should set the basis for more effective therapeutic strategies for sexually dimorphic diseases.
C1 [Eghbali, Mansoureh] Univ Calif Los Angeles, David Geffen Sch Med, Dept Anesthesiol, Div Mol Med, Los Angeles, CA 90095 USA.
   Univ Calif Los Angeles, David Geffen Sch Med, Cardiovasc Res Labs, Los Angeles, CA 90095 USA.
C3 University of California System; University of California Los Angeles;
   University of California Los Angeles Medical Center; David Geffen School
   of Medicine at UCLA; University of California System; University of
   California Los Angeles; University of California Los Angeles Medical
   Center; David Geffen School of Medicine at UCLA
RP Eghbali, M (corresponding author), Univ Calif Los Angeles, David Geffen Sch Med, Dept Anesthesiol, Div Mol Med, BH-160CHS, Los Angeles, CA 90095 USA.
EM meghbali@ucla.edu
RI Eghbali, Mansour/M-3165-2017
FU National Institutes of Health [NIH R01HL089876]; American Heart
   Association Postdoctoral Fellowship [13POST17240020]; American Heart
   Association (AHA) [13POST17240020] Funding Source: American Heart
   Association (AHA)
FX This work was supported by grants from the National Institutes of Health
   (NIH R01HL089876 to ME) and American Heart Association Postdoctoral
   Fellowship (13POST17240020 to SS). The funders had no role in the design
   and preparation of the manuscript or decision to publish.
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NR 138
TC 156
Z9 168
U1 0
U2 37
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 2042-6410
J9 BIOL SEX DIFFER
JI Biol. Sex Differ.
PD FEB 1
PY 2014
VL 5
AR 3
DI 10.1186/2042-6410-5-3
PG 8
WC Endocrinology & Metabolism; Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Genetics & Heredity
GA AE0NZ
UT WOS:000333664300001
PM 24484532
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Wang, YH
   Hu, H
   Wang, SP
   Tian, ZJ
   Zhang, QJ
   Li, QX
   Li, YY
   Yu, XJ
   Sun, L
   Li, DL
   Jia, B
   Liu, BH
   Zang, WJ
AF Wang, You-Hua
   Hu, Hao
   Wang, Sheng-Peng
   Tian, Zhen-Jun
   Zhang, Quan-Jiang
   Li, Qiu-Xia
   Li, You-You
   Yu, Xiao-Jiang
   Sun, Lei
   Li, Dong-Ling
   Jia, Bing
   Liu, Bing-Hang
   Zang, Wei-Jin
TI Exercise benefits cardiovascular health in hyperlipidemia rats
   correlating with changes of the cardiac vagus nerve
SO EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
LA English
DT Article
DE Cardiac function; Blood lipids; Inflammatory cytokine;
   Cholinesterase-positive nerve; Muscarinic cholinergic (M-2) receptor
ID CHOLINERGIC ANTIINFLAMMATORY PATHWAY; MUSCARINIC
   ACETYLCHOLINE-RECEPTORS; CHRONIC HEART-FAILURE; NITRIC-OXIDE;
   PROINFLAMMATORY CYTOKINES; METABOLIC SYNDROME; NEUROPEPTIDE-Y; STRESS;
   DIET; ATHEROSCLEROSIS
AB The role of exercise training on hemodynamic parameters, blood lipid profiles, inflammatory cytokines, cholinesterase-positive nerves and muscarinic cholinergic (M-2) receptors expression in the heart was investigated in Sprague-Dawley male rats with hyperlipidemia (HL). The rats were subjected to a high-fat diet and exercise training for 8 weeks, and then the hemodynamic parameters, the profiles of blood lipid and inflammatory cytokines, and the expression of cholinesterase-positive nerves and M-2 receptors were measured. HL rats displayed cardiac dysfunction, dysregulation of inflammatory cytokines, and decreased cholinesterase-positive nerves and M-2 receptors expression. The combination of hyperlipidemia with exercise training (AT) restored the profiles of blood lipids and the levels of inflammatory cytokines. In addition, AT and HL + AT improved cardiac function with increasing cholinesterase-positive nerves and M-2 receptors expression. Overall, these data show that the increased expression of cholinesterase-positive nerves and M-2 receptors in the heart is partially responsible for the benefits of exercise training on cardiac function in hyperlipidemia rats.
C1 [Wang, You-Hua; Hu, Hao; Wang, Sheng-Peng; Yu, Xiao-Jiang; Sun, Lei; Li, Dong-Ling; Jia, Bing; Liu, Bing-Hang; Zang, Wei-Jin] Xi An Jiao Tong Univ, Dept Pharmacol, Sch Med, Xian 710049, Peoples R China.
   [Wang, You-Hua; Tian, Zhen-Jun; Zhang, Quan-Jiang; Li, Qiu-Xia; Li, You-You] Shaanxi Normal Univ, Dept Phys Educ, Xian, Peoples R China.
C3 Xi'an Jiaotong University; Shaanxi Normal University
RP Zang, WJ (corresponding author), Xi An Jiao Tong Univ, Dept Pharmacol, Sch Med, Xian 710049, Peoples R China.
EM zwj@mail.xjtu.edu.cn
RI Wang, Shengpeng/HRA-8956-2023; lei, sun/HGE-2755-2022; Wang,
   Xuejun/K-8874-2013; Zhang, Xing/ACQ-5035-2022; Tian,
   Zhenjun/HTP-4121-2023
OI Li, Qiuxia/0000-0001-5835-0749; Zhang, QuanJiang/0000-0003-0182-7491
FU National Natural Science Foundation of China [30930105, 30873058,
   30770785]; National Basic Research Program of China [2007CB512005]; CMB
   Distinguished Professorships [F510000/G16916404]
FX This work was supported by grants from the National Natural Science
   Foundation of China (Key Program, No. 30930105; General Program, No.
   30873058, 30770785), the National Basic Research Program of China (973
   Program, No. 2007CB512005) and CMB Distinguished Professorships Award
   (No. F510000/G16916404).
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NR 44
TC 14
Z9 19
U1 0
U2 7
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1439-6319
EI 1439-6327
J9 EUR J APPL PHYSIOL
JI Eur. J. Appl. Physiol.
PD FEB
PY 2010
VL 108
IS 3
BP 459
EP 468
DI 10.1007/s00421-009-1232-1
PG 10
WC Physiology; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology; Sport Sciences
GA 546CW
UT WOS:000273787000006
PM 19830451
DA 2025-06-11
ER

PT J
AU Anson, NM
   Havenaar, R
   Bast, A
   Haenen, GRMM
AF Anson, Nuria Mateo
   Havenaar, Robert
   Bast, Aalt
   Haenen, Guido R. M. M.
TI Antioxidant and anti-inflammatory capacity of bioaccessible compounds
   from wheat fractions after gastrointestinal digestion
SO JOURNAL OF CEREAL SCIENCE
LA English
DT Article
DE Aleurone; Antioxidant capacity; TNF-alpha; Bioaccessible ferulic acid
ID WHOLE-GRAIN INTAKE; FERULIC ACID; METABOLIC SYNDROME; OXIDATIVE STRESS;
   IN-VITRO; OLDER-ADULTS; CELL-LINE; BRAN; ALEURONE; MODEL
AB Wholegrain consumption is associated with several health benefits, in contrast to the consumption of refined grains. This can partly be related to the antioxidant compounds in the outer parts of the grain kernel. The bioaccessibility of these antioxidant compounds from the wholegrain matrix during gastrointestinal digestion is crucial for their absorption and bioavailability. In the current study, the bioaccessible compounds from aleurone, bran and flour were obtained from a dynamic in vitro model of the upper gastrointestinal tract. They were collected at 1 h time intervals to assess their antioxidant capacity (TEAC assay) and also their anti-inflammatory effect (TNF-alpha reduction in U937 macrophages stimulated with LPS). The bioaccessible compounds from aleurone had the highest antioxidant capacity and provided a prolonged anti-inflammatory effect, shown by the TNF-alpha reduction of a relatively late time-interval (3-4 h after start of digestion). The contribution of feruilic acid to those effects was minor due to its low bioaccessibility. Aleurone seems a promising wheat fraction for cereal products with a healthy added value. (c) 2009 Elsevier Ltd. All rights reserved.
C1 [Anson, Nuria Mateo] Univ Maastricht, Dept Pharmacol & Toxicol, NL-6200 MD Maastricht, Netherlands.
   [Anson, Nuria Mateo; Havenaar, Robert] TNO Qual Life, NL-3700 AJ Zeist, Netherlands.
C3 Maastricht University; Netherlands Organization Applied Science Research
RP Anson, NM (corresponding author), Univ Maastricht, Dept Pharmacol & Toxicol, POB 616, NL-6200 MD Maastricht, Netherlands.
EM Nuria.mateoanson@tno.nl
RI Haenen, Guido/H-9209-2013; Havenaar, Robert/AAS-2874-2021; Bast,
   Aalt/I-7809-2013
OI Bast, Aalt/0000-0002-5383-2789; Haenen, Guido/0000-0001-6986-290X
FU European Commission [FOOD-CT-2005-514008]
FX This research was financially supported by the European Commission in
   the Communities 6th Framework Programme, Project HEALTHGRAIN
   (FOOD-CT-2005-514008). It reflects the author's views and the Community
   is not liable for any use that may be made of the information contained
   in this publication.
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NR 34
TC 47
Z9 52
U1 0
U2 35
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 0733-5210
EI 1095-9963
J9 J CEREAL SCI
JI J. Cereal Sci.
PD JAN
PY 2010
VL 51
IS 1
BP 110
EP 114
DI 10.1016/j.jcs.2009.10.005
PG 5
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA 559YF
UT WOS:000274867600016
DA 2025-06-11
ER

PT J
AU Chavda, V
   Patel, S
AF Chavda, Vishal
   Patel, Snehal
TI Hyperglycaemic Metabolic Complications of Ischemic Brain: Current
   Therapeutics, Anti-Diabetics and Stem Cell Therapy
SO CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
LA English
DT Review
DE Cerebrovascular stroke; diabetes; neurovascular complications;
   Hyperglycaemia; ischemic insult; neurodegeneration
ID HEALTH-CARE PROFESSIONALS; GLYCATION END-PRODUCTS; OXIDATIVE STRESS;
   BARRIER PERMEABILITY; COGNITIVE IMPAIRMENT; ENDOTHELIAL-CELLS; STROKE
   REHABILITATION; GLUCOSE-METABOLISM; ANTIDIABETIC DRUGS; MOTOR RECOVERY
AB Stroke is the leading cause of morbidity and mortality in diabetic patients. Diabetes alters the endothelial function and disrupts brain pathways, resulting in a variety of systemic metabolic complications. Diabetics not only have impaired neurotransmission, but also have progressive neurodegeneration, which leads to long-term neurological complications. Diabetes risk factors and physiology alter the frequency and severity of cardiovascular and cerebrovascular events, necessitating more hospitalizations. Stroke and diabetes have a mutually reinforcing relationship that worsens their outcomes. Diabetes has far-reaching systemic consequences for human physiology as a metabolic syndrome. As a result, diabetic stroke patients require dual-therapeutics with dual protection. Scientific researchers have made tremendous progress in diabetes-related stroke and its therapeutics over the last few decades. We have summarised diabetic brain and associated risk factors, co-morbidities, biomarkers, and hyperglycemia-associated neurovascular insult and cognitive demur. In addition to providing an overview of the effects of hyperglycaemia on brain physiology, this article aims to summarise the evidence from current glucose-lowering treatment, recent advances in stroke therapeutics as well as exploring stem cell therapy in the management of diabetes-associated stroke.
C1 [Chavda, Vishal; Patel, Snehal] Nirma Univ, Dept Pharmacol, Pharmacol Res Lab, Ahmadabad 382481, Gujarat, India.
C3 Nirma University
RP Patel, S (corresponding author), Nirma Univ, Dept Pharmacol, Pharmacol Res Lab, Ahmadabad 382481, Gujarat, India.
EM Snehalpharma53@gmail.com
RI Chavda, Vishal/AFH-3768-2022
OI Chavda, Dr. Vishal/0000-0002-5812-3412
FU CSIR (Council for Scientific and Industrial Research) [111115/2K18/1,
   09/1048(0011)/2019-EMR-1]
FX The author (Vishal K Chavda) would like to acknowledge CSIR (Council for
   Scientific and Industrial Research) for providing CSIR-SRF (Senior
   Research Fellowship -Ack/no. 111115/2K18/1; File Number
   09/1048(0011)/2019-EMR-1) during Ph.D. tenure. The authors would like to
   acknowledge Dr. Ghulam Md Ashraf and Dr. Badrah Alghamdi, Department of
   Physiology, King Abdulaziz University for their expert suggestions in
   improving the overall quality of this review manuscript.
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NR 218
TC 1
Z9 1
U1 0
U2 2
PU BENTHAM SCIENCE PUBL
PI BUSUM
PA PO BOX 294, BUSUM, 1400 AG, NETHERLANDS
SN 1871-5273
EI 1996-3181
J9 CNS NEUROL DISORD-DR
JI CNS Neurol. Disord.-Drug Targets
PY 2023
VL 22
IS 6
BP 832
EP 856
DI 10.2174/1871527321666220609200852
PG 25
WC Neurosciences; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pharmacology & Pharmacy
GA I7MO2
UT WOS:001004593100005
PM 35692163
DA 2025-06-11
ER

PT J
AU Park, K
   Lee, MS
AF Park, Kihyoun
   Lee, Myung-Shik
TI Current Status of Autophagy Enhancers in Metabolic Disorders and Other
   Diseases
SO FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
LA English
DT Review
DE autophagy; modulator; metabolic diseases; lysosome; mitochondria;
   endoplasmic reticulum
ID ENDOPLASMIC-RETICULUM STRESS; ISLET AMYLOID POLYPEPTIDE; ACTIVATED
   RECEPTOR-ALPHA; PANCREATIC BETA-CELLS; LIFE-SPAN EXTENSION;
   INSULIN-RESISTANCE; TYROSINE KINASE; HUNTINGTONS-DISEASE; MOUSE MODEL;
   MITOCHONDRIAL-FUNCTION
AB Autophagy is pivotal in the maintenance of organelle function and intracellular nutrient balance. Besides the role of autophagy in the homeostasis and physiology of the individual tissues and whole organism in vivo, dysregulated autophagy has been incriminated in the pathogenesis of a variety of diseases including metabolic diseases, neurodegenerative diseases, cardiovascular diseases, inflammatory or immunological disorders, cancer and aging. Search for autophagy modulators has been widely conducted to amend dysregulation of autophagy or pharmacologically modulate autophagy in those diseases. Current data support the view that autophagy modulation could be a new modality for treatment of metabolic syndrome associated with lipid overload, human-type diabetes characterized by deposition of islet amyloid or other diseases including neurodegenerative diseases, infection and cardiovascular diseases. While clinically available bona fide autophagy modulators have not been developed yet, it is expected that on-going investigation will lead to the development of authentic autophagy modulators that can be safely administered to patients in the near future and will open a new horizon for treatment of incurable or difficult diseases.
C1 [Lee, Myung-Shik] Yonsei Univ, Coll Med, Dept Internal Med, Severance Biomed Sci Inst, Seoul, South Korea.
   Soonchunhyang Univ, Soonchunhyang Inst Medi Bio Sci, Cheonan, South Korea.
C3 Yonsei University; Yonsei University Health System; Soonchunhyang
   University
RP Lee, MS (corresponding author), Yonsei Univ, Coll Med, Dept Internal Med, Severance Biomed Sci Inst, Seoul, South Korea.
EM mslee0923@yuhs.ac
RI Lee, Myung/C-9606-2011
OI park, kihyoun/0000-0002-3010-4746; Lee, Myung-Shik/0000-0003-3292-1720
FU National Research Foundation of Korea (NRF) - Korea government (MSIT)
   [NRF-2019R1A2C3002924]; Bio&Medical Technology Development Program
   [2017M3A9G7073521]; Faculty Research Assistance Program of Yonsei
   University College of Medicine [6-2016-0055]; A3 Foresight Program of
   the NRF [2015K2A2A6002060]
FX & nbsp;This study was supported by a National Research Foundation of
   Korea (NRF) grant funded by the Korea government (MSIT)
   (NRF-2019R1A2C3002924) and by the Bio&Medical Technology Development
   Program (2017M3A9G7073521). M-SL is the recipient of a grant from the
   Faculty Research Assistance Program of Yonsei University College of
   Medicine (6-2016-0055) and A3 Foresight Program of the NRF
   (2015K2A2A6002060).
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NR 245
TC 14
Z9 14
U1 0
U2 21
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-634X
J9 FRONT CELL DEV BIOL
JI Front. Cell. Dev. Biol.
PD FEB 14
PY 2022
VL 10
AR 811701
DI 10.3389/fcell.2022.811701
PG 21
WC Cell Biology; Developmental Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Developmental Biology
GA ZI5LP
UT WOS:000761662700001
PM 35237600
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Samblas, M
   Milagro, FI
   Mansego, ML
   Marti, A
   Martinez, JA
AF Samblas, M.
   Milagro, F. I.
   Mansego, M. L.
   Marti, A.
   Martinez, J. A.
CA GENOI Members
TI PTPRS and PER3 methylation levels are associated with
   childhood obesity: results from a genome-wide methylation analysis
SO PEDIATRIC OBESITY
LA English
DT Article
DE Circadian; clock; epigenetics; inflammation; weight
ID METABOLIC SYNDROME; EXPRESSION; RECEPTOR; PROTEIN; ADOLESCENTS; CHILDREN
AB BackgroundThe global prevalence of childhood overweight and obesity has increased in the last years. Epigenetic dysregulation affecting gene expression could be a determinant in early-life obesity onset and accompanying complications.
   ObjectiveThe aim of the present investigation was to analyse the putative association between DNA methylation and childhood obesity.
   MethodsDNA was isolated from white blood cells of 24 children obtained from the GENOI study and was hybridized in a 450K methylation array. Two CpG sites associated with obesity were validated in 91 children by MassArray (R) EpiTyper technology.
   ResultsGenome-wide analysis identified 734 CpGs (783 genes) differentially methylated between cases (n=12) and controls (n=12). Ingenuity Pathway Analysis showed that these genes were involved in oxidative stress and circadian rhythm signalling pathways. Moreover, the DNA methylation levels of VIPR2, GRIN2D, ADCYAP1R1, PER3 and PTPRS regions correlated with the obesity trait. EpiTyper validation also identified significant correlations between methylation levels of CpG sites on PTPRS and PER3 with BMI z-score.
   ConclusionsThis study identified several CpG sites and specifically several CpGs in the PTPRS and PER3 genes differentially methylated between obese and non-obese children, suggesting a role for DNA methylation concerning development of childhood obesity.
C1 [Samblas, M.; Milagro, F. I.; Mansego, M. L.; Marti, A.; Martinez, J. A.] Univ Navarra, Dept Nutr Food Sci & Physiol, Pamplona, Spain.
   [Samblas, M.; Milagro, F. I.; Mansego, M. L.; Martinez, J. A.] Univ Navarra, Ctr Nutr Res, Pamplona, Spain.
   [Milagro, F. I.; Marti, A.; Martinez, J. A.] Carlos III Inst, CIBERobn, Physiopathol Obes, Madrid, Spain.
   [Marti, A.; Martinez, J. A.] Navarras Hlth Res Inst, IdiSNA, Pamplona, Spain.
C3 University of Navarra; University of Navarra; CIBER - Centro de
   Investigacion Biomedica en Red; CIBEROBN
RP Martinez, JA (corresponding author), Univ Navarra, Dept Nutr Food Sci & Physiol, Irunlarrea 1, Navarra 31008, Spain.
EM jalfmtz@unav.es
RI Martínez, J./K-8709-2014; Milagro, Fermin/F-2315-2015; Marti del Moral,
   Amelia/H-1192-2017; MANSEGO, MARIA/A-5687-2011
OI Milagro, Fermin I./0000-0002-3228-9916; Marti del Moral,
   Amelia/0000-0001-9832-7981; Samblas-Garcia, Mirian/0000-0003-0866-2300;
   MANSEGO, MARIA/0000-0001-8914-7890
FU Ministerio de Economia y Competitividad, Secretaria de Estado de
   Investigacion, Desarrollo e Innovacion [AGL2013-45554-R]; MECD
   [BES-2014-068409]
FX We thank the participants of the GENOI study, and Enrique Buso
   (University of Valencia), Enrique Goni and Ana Lorente (University of
   Navarra) for technical and statistical assistance. We acknowledge the
   financial support of Ministerio de Economia y Competitividad, Secretaria
   de Estado de Investigacion, Desarrollo e Innovacion (Nutrigenio Project,
   AGL2013-45554-R). Mirian Samblas holds a FPI grant from the MECD
   (BES-2014-068409).
CR Bacos K, 2016, NAT COMMUN, V7, DOI 10.1038/ncomms11089
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NR 30
TC 36
Z9 37
U1 1
U2 30
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2047-6310
EI 2047-6302
J9 PEDIATR OBES
JI Pediatr. Obes.
PD MAR
PY 2018
VL 13
IS 3
SI SI
BP 149
EP 158
DI 10.1111/ijpo.12224
PG 10
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA FW7AZ
UT WOS:000425472900003
PM 28614626
DA 2025-06-11
ER

PT J
AU Ha, JY
   Kim, MK
   Kang, S
   Nam, JS
   Ahn, CW
   Kim, KR
   Park, JS
AF Ha, Ji Yoon
   Kim, Min Kyung
   Kang, Shinae
   Nam, Ji Sun
   Ahn, Chul Woo
   Kim, Kyung Rae
   Park, Jong Suk
TI Serum ferritin levels are associated with arterial stiffness in healthy
   Korean adults
SO VASCULAR MEDICINE
LA English
DT Article
DE arterial stiffness; atherosclerosis; ferritin
ID PULSE-WAVE VELOCITY; BODY IRON STORES; INSULIN-RESISTANCE; METABOLIC
   SYNDROME; OXIDATIVE STRESS; MYOCARDIAL-INFARCTION;
   HEMODIALYSIS-PATIENTS; VASCULAR DAMAGE; HEART-DISEASE; RISK
AB Although an association between serum ferritin and atherosclerosis has been suggested, limited epidemiologic data are available regarding the association between ferritin and arterial stiffness in healthy adults. A total of 2932 healthy subjects were enrolled in this study. Anthropometric and biochemical profiles including ferritin were measured. The arterial stiffness was measured using brachial-ankle pulse wave velocity (baPWV). Serum ferritin levels were classified into quartiles and baPWV values gradually increased with each ferritin quartile. Multiple regression analysis showed that ferritin levels were independently correlated with baPWV. After adjusting for multiple risk factors, as compared with the lowest quartile, the odds ratios for high baPWV (>75(th) percentile) were 1.15 (0.84-1.56), 1.37 (0.97-1.73), and 1.46 (1.29-2.17) among men (p for trend < 0.05) and 1.24 (0.87-1.79), 1.53 (1.09-2.16), and 1.80 (1.25-2.82) among women (p for trend < 0.05), for the second, third, and fourth quartiles of ferritin, respectively. In conclusion, serum ferritin levels are independently associated with arterial stiffness in healthy Korean adults.
C1 [Ha, Ji Yoon; Kim, Min Kyung; Kang, Shinae; Nam, Ji Sun; Ahn, Chul Woo; Kim, Kyung Rae; Park, Jong Suk] Yonsei Univ, Dept Internal Med, Coll Med, Seoul, South Korea.
   [Kang, Shinae; Nam, Ji Sun; Ahn, Chul Woo; Park, Jong Suk] Yonsei Univ, Severance Inst Vasc & Metab Res, Coll Med, Seoul, South Korea.
C3 Yonsei University; Yonsei University Health System; Yonsei University;
   Yonsei University Health System
RP Park, JS (corresponding author), Gangnam Severance Hosp, Dept Internal Med, Div Endocrinol, 146-92 Dogok Dong,POB 135-720, Seoul, South Korea.
EM pjs00@yuhs.ac
RI Kim, Myung/J-5392-2012; Kim, Hak-Jae/Q-9368-2019
OI Ahn, Chul Woo/0000-0003-3733-7486; Nam, Ji Sun/0000-0001-8655-5258;
   Kang, Shinae/0000-0002-9719-4774; Park, Jong Suk/0000-0002-5385-1373
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NR 37
TC 6
Z9 6
U1 0
U2 2
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1358-863X
EI 1477-0377
J9 VASC MED
JI Vasc. Med.
PD AUG
PY 2016
VL 21
IS 4
BP 325
EP 330
DI 10.1177/1358863X16629728
PG 6
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA DS7KQ
UT WOS:000380962800002
PM 26926288
OA Bronze
DA 2025-06-11
ER

PT J
AU Cardinali, DP
   Brown, GM
   Pandi-Perumal, SR
AF Cardinali, Daniel P.
   Brown, Gregory M.
   Pandi-Perumal, Seithikurippu R.
TI Possible Application of Melatonin in Long COVID
SO BIOMOLECULES
LA English
DT Review
DE brain fog; COVID-19; fibromyalgia; long COVID; melatonin; minimal
   cognitive impairment; myalgic encephalomyelitis/chronic fatigue
   syndrome; SARS-CoV-2 virus
ID AMYLOID-BETA-PEPTIDE; ALZHEIMERS-DISEASE; OXIDATIVE STRESS; SLEEP;
   NEURODEGENERATION; METAANALYSIS; INHIBITION; IMPAIRMENT; APOPTOSIS;
   INSOMNIA
AB Clinical sequelae and symptoms for a considerable number of COVID-19 patients can linger for months beyond the acute stage of SARS-CoV-2 infection, "long COVID". Among the long-term consequences of SARS-CoV-2 infection, cognitive issues (especially memory loss or "brain fog"), chronic fatigue, myalgia, and muscular weakness resembling myalgic encephalomyelitis/chronic fatigue syndrome (ME /CFS) are of importance. Melatonin may be particularly effective at reducing the signs and symptoms of SARS-CoV-2 infection due to its functions as an antioxidant, anti-inflammatory, and immuno-modulatory agent. Melatonin is also a chronobiotic medication effective in treating delirium and restoring the circadian imbalance seen in COVID patients in the intensive care unit. Additionally, as a cytoprotector, melatonin aids in the prevention of several COVID-19 comorbidities, including diabetes, metabolic syndrome, and ischemic and non-ischemic cardiovascular diseases. This narrative review discusses the application of melatonin as a neuroprotective agent to control cognitive deterioration ("brain fog") and pain in the ME/CFS syndrome-like documented in long COVID. Further studies on the therapeutic use of melatonin in the neurological sequelae of SARS-CoV-2 infection are warranted.
C1 [Cardinali, Daniel P.] Pontif Univ Catolica Argentina, Fac Med Sci, Buenos Aires, Argentina.
   [Brown, Gregory M.] Univ Toronto, Dept Psychiat, Ctr Addict & Mental Hlth, Toronto, ON M5T 1R8, Canada.
   [Pandi-Perumal, Seithikurippu R.] Saveetha Univ, Saveetha Inst Med & Tech Sci, Saveetha Med Coll & Hosp, Chennai 600077, India.
C3 Pontificia Universidad Catolica Argentina; University of Toronto; Centre
   for Addiction & Mental Health - Canada; Saveetha Institute of Medical &
   Technical Science; Saveetha Medical College & Hospital
RP Pandi-Perumal, SR (corresponding author), Saveetha Univ, Saveetha Inst Med & Tech Sci, Saveetha Med Coll & Hosp, Chennai 600077, India.
EM pandiperumal2022@gmail.com
RI Brown, Gregory/ACV-1983-2022; Pandi-Perumal, Seithikurippu/Q-8281-2016;
   Pandi-Perumal, Seithikurippu R/C-6767-2008
OI Pandi-Perumal, Seithikurippu R/0000-0002-8686-7259
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NR 94
TC 18
Z9 18
U1 1
U2 6
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2218-273X
J9 BIOMOLECULES
JI Biomolecules
PD NOV
PY 2022
VL 12
IS 11
AR 1646
DI 10.3390/biom12111646
PG 10
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 6B0TC
UT WOS:000881055700001
PM 36358996
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Wu, QB
   Chen, ZH
   Ding, Y
   Tang, YT
   Cheng, YW
AF Wu, Qiongbo
   Chen, Zihao
   Ding, Yi
   Tang, Yunting
   Cheng, Yawei
TI Protective effect of traditional Chinese medicine on non-alcoholic fatty
   liver disease and liver cancer by targeting ferroptosis
SO FRONTIERS IN NUTRITION
LA English
DT Review
DE traditional Chinese medicine; active ingredient; ferroptosis;
   non-alcoholic fatty liver disease; protective effect
ID RESEARCH PROGRESS; CELL-DEATH; IRON; QUERCETIN; METABOLISM; ACTIVATION;
   MECHANISMS; APOPTOSIS; FIBROSIS; STRESS
AB Non-alcoholic fatty liver disease (NAFLD) is a chronic liver disease with high incidence and is closely related to metabolic syndrome. If not controlled, it may eventually become hepatocellular carcinoma (HCC). Ferroptosis, a non-apoptotic form of programmed cell death (PCD), is closely related to NAFLD and HCC, and the mechanisms of action involved are more complex. Some studies have demonstrated that many drugs inhibit ferroptosis and protect liver steatosis or carcinogenesis. The role of Traditional Chinese Medicine (TCM), especially herbs or herbal extracts, has received increasing attention. However, there are relatively few review articles on the regulation of NAFLD by TCM through ferroptosis pathway. Here, we summarize the TCM intervention mechanism and application affecting NAFLD/NAFLD-HCC via regulation of ferroptosis. This article focuses on the relationship between ferroptosis and NAFLD or NAFLD-HCC and the protective effect of TCM on both by targeting ferroptosis. It not only summarizes the mechanism of early prevention and treatment of NAFLD, but also provides reference ideas for the development of TCM for the treatment of metabolic diseases and liver diseases.
C1 [Wu, Qiongbo; Ding, Yi; Tang, Yunting; Cheng, Yawei] Hainan Prov Hosp Tradit Chinese Med, Haikou, Peoples R China.
   [Wu, Qiongbo; Ding, Yi; Tang, Yunting; Cheng, Yawei] Hainan Clin Res Ctr Prevent Treatment Dis, Haikou, Peoples R China.
   [Wu, Qiongbo; Chen, Zihao] Natl Univ Singapore, Food Sci & Technol Ctr, Suzhou Res Inst, Suzhou, Peoples R China.
C3 National University of Singapore
RP Cheng, YW (corresponding author), Hainan Prov Hosp Tradit Chinese Med, Haikou, Peoples R China.; Cheng, YW (corresponding author), Hainan Clin Res Ctr Prevent Treatment Dis, Haikou, Peoples R China.
EM yaweicheng1982@163.com
RI Chen, zihao/HGE-3792-2022
FU Construction Project of Preventive Treatment Department of Key Specialty
   of Traditional Chinese Medicine in Hainan Province; Hainan Province
   Major Science and Technology Projects;  [2019-6];  [ZDKJ2021034]
FX Funding This work was supported by the Construction Project of
   Preventive Treatment Department of Key Specialty of Traditional Chinese
   Medicine in Hainan Province (grant no. 2019-6) and Hainan Province Major
   Science and Technology Projects (ZDKJ2021034).
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NR 100
TC 22
Z9 26
U1 18
U2 66
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD OCT 18
PY 2022
VL 9
AR 1033129
DI 10.3389/fnut.2022.1033129
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 5X1YG
UT WOS:000878401100001
PM 36330148
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Galizzi, G
   Palumbo, L
   Amato, A
   Conigliaro, A
   Nuzzo, D
   Terzo, S
   Caruana, L
   Picone, P
   Alessandro, R
   Mulè, F
   Di Carlo, M
AF Galizzi, Giacoma
   Palumbo, Laura
   Amato, Antonella
   Conigliaro, Alice
   Nuzzo, Domenico
   Terzo, Simona
   Caruana, Luca
   Picone, Pasquale
   Alessandro, Riccardo
   Mule, Flavia
   Di Carlo, Marta
TI Altered insulin pathway compromises mitochondrial function and quality
   control both in in vitro and in vivo model
   systems
SO MITOCHONDRION
LA English
DT Article
DE Insulin pathway; Neurodegeneration; Metabolic diseases; Mitochondrion;
   Mitophagy; Aging
ID INDUCED CELL-DEATH; ALZHEIMERS-DISEASE; AMYLOID-BETA; OXIDATIVE STRESS;
   DYSFUNCTION; RESISTANCE; AUTOPHAGY; VDAC1; AKT; NEURODEGENERATION
AB Altered insulin signaling and insulin resistance are considered the link between Alzheimer's disease (AD) and metabolic syndrome. Here, by using an in vitro and an in vivo model, we investigated the relationship between these disorders focusing on neuronal mitochondrial dysfunction and mitophagy. In vitro A beta insult induced the opening of mitochondrial permeability transition pore (mPTP), mitochondrial membrane potential (Delta psi m) loss, and apoptosis while insulin addition ameliorated these dysfunctions. The same alterations were detected in a 16 weeks of age mouse model of diet-induced obesity and insulin resistance. In addition, we detected an increase of fission related proteins and activation of mitophagy, proved by the rise of PINK1 and Parkin proteins. Nevertheless, in vitro, the increase of p62 and LC3 indicated an alteration in autophagy, while, in vivo decreased expression of p62 and increase of LC3 suggested removing of damaged mitochondria. Finally, in aged mice (28 and 48 weeks), the data indicated impairment of mitophagy and suggested the accumulation of damaged mitochondria. Taken together these outcomes indicate that alteration of the insulin pathway affects mitochondrial integrity, and effective mitophagy is age-dependent.
C1 [Galizzi, Giacoma; Palumbo, Laura; Nuzzo, Domenico; Caruana, Luca; Picone, Pasquale; Alessandro, Riccardo; Di Carlo, Marta] CNR, Ist Ricerca & Innovaz Biomed IRIB, Via U La Malfa 153, I-90146 Palermo, Italy.
   [Amato, Antonella; Terzo, Simona; Mule, Flavia] Univ Palermo, Dipartimento Sci & Tecnol Biol Chim & Farmaceut S, Viale Sci, I-90128 Palermo, Italy.
   [Conigliaro, Alice; Alessandro, Riccardo] Univ Palermo, Dipartimento Biomed Neurosci & Diagnost Avanzata, Via Vespro 129, I-90127 Palermo, Italy.
   [Terzo, Simona] Univ Palermo, Dipartimento Biomed Neurosci & Diagnost Avanzata, Sez Anat Umana, Via Vespro 129, I-90127 Palermo, Italy.
C3 Consiglio Nazionale delle Ricerche (CNR); University of Palermo;
   University of Palermo; University of Palermo
RP Di Carlo, M (corresponding author), CNR, Ist Ricerca & Innovaz Biomed IRIB, Via U La Malfa 153, I-90146 Palermo, Italy.
EM marta.dicarlo@irib.cnr.it
RI Palumbo, Laura/AAC-6772-2022; Picone, Pasquale/AAX-3158-2020; Amato,
   Antonella/AAX-8821-2020; Conigliaro, Alice/ACW-5549-2022; nuzzo,
   domenico/X-9914-2019
OI nuzzo, domenico/0000-0002-4325-417X; Palumbo, Laura/0000-0002-9041-5407;
   GALIZZI, GIACOMA/0000-0002-2309-1166
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NR 69
TC 19
Z9 19
U1 1
U2 5
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1567-7249
EI 1872-8278
J9 MITOCHONDRION
JI Mitochondrion
PD SEP
PY 2021
VL 60
BP 178
EP 188
DI 10.1016/j.mito.2021.08.014
EA SEP 2021
PG 11
WC Cell Biology; Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Genetics & Heredity
GA WB7OV
UT WOS:000703759500006
PM 34454074
DA 2025-06-11
ER

PT J
AU Virtuoso, A
   Forkman, B
   Sarruf, DA
   Tveden-Nyborg, P
   Sorensen, DB
AF Virtuoso, Alessandro
   Forkman, Bjoern
   Sarruf, David A.
   Tveden-Nyborg, Pernille
   Sorensen, Dorte Bratbo
TI A cafeteria diet alters the decision making strategy and metabolic
   markers in Sprague-Dawley male rats
SO APPLIED ANIMAL BEHAVIOUR SCIENCE
LA English
DT Article
DE Obesity; Rat; Decision making; Leptin; FGF21; Cognition
ID HIGH-FAT DIET; CHRONIC VARIABLE STRESS; COGNITIVE FUNCTION;
   INSULIN-RESISTANCE; INDUCED OBESITY; ENVIRONMENTAL ENRICHMENT; MEMORY
   IMPAIRMENT; INFLAMMATION; FOOD; TIME
AB Consumption of diets rich in refined sugar and saturated fat has been linked with development of mild cognitive impairment and dementia in humans. Most cognitive paradigms used in biomedical research to investigate the relationship between obesity and cognition rely on food motivation and speed of completion of a task, both of which can be influenced by the physiological changes induced by obesity. Here we assess the effects of an energy rich diet (Cafeteria Diet, CAF) on the performance of male Sprague-Dawley rats in the Decision Making paradigm, an operant conditioning task using water as a reinforcer and based on the patch depletion paradigm of optimal foraging in a test that is independent from motivation and time budget. As expected, CAF diet resulted in increased body weight and circulating leptin and insulin levels. Our results show that the decision rule of rats fed a CAF is altered at one month after diet initiation. In absence of insulin resistance and dyslipidemia, these results show that the CAF influences the cognitive performance of male rats in the DM prior to signs of developing metabolic syndrome.
C1 [Virtuoso, Alessandro; Forkman, Bjoern; Tveden-Nyborg, Pernille; Sorensen, Dorte Bratbo] Univ Copenhagen, Fac Hlth & Med Sci, Dept Vet & Anim Sci, Frederiksberg, Denmark.
   [Sarruf, David A.] Novo Nordisk AS, Incretin & Obes Pharmacol, Malov, Denmark.
C3 University of Copenhagen; Novo Nordisk
RP Sorensen, DB (corresponding author), Sect Expt Anim Models, Thorvaldsensvej 57 Stuen, DK-1870 Frederiksberg C, Denmark.
EM a.virtuoso@hotmail.com; bjf@sund.ku.dk; davesarruf@gmail.com;
   ptn@sund.ku.dk; brat@sund.ku.dk
RI Forkman, Björn/I-4885-2012
OI Forkman, Bjorn/0000-0002-0153-6240; Virtuoso,
   Alessandro/0000-0002-1227-4709; Tveden-Nyborg,
   Pernille/0000-0002-5574-5742; Sorensen, Dorte Bratbo/0000-0002-6144-1710
FU Novo Nordisk-LIFE In Vivo Pharmacology Centre (LIFEPHARM)
FX This study was funded by the Novo Nordisk-LIFE In Vivo Pharmacology
   Centre (LIFEPHARM).
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NR 58
TC 3
Z9 3
U1 0
U2 19
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0168-1591
EI 1872-9045
J9 APPL ANIM BEHAV SCI
JI Appl. Anim. Behav. Sci.
PD FEB
PY 2018
VL 199
BP 35
EP 44
DI 10.1016/j.applanim.2017.10.012
PG 10
WC Agriculture, Dairy & Animal Science; Behavioral Sciences; Veterinary
   Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture; Behavioral Sciences; Veterinary Sciences
GA FW8FJ
UT WOS:000425564500006
DA 2025-06-11
ER

PT J
AU Thompson, K
   Pederick, W
   Singh, I
   Santhakumar, AB
AF Thompson, Kiara
   Pederick, Wayne
   Singh, Indu
   Santhakumar, Abishek Bommannan
TI Anthocyanin supplementation in alleviating thrombogenesis in overweight
   and obese population: A randomized, double-blind, placebo-controlled
   study
SO JOURNAL OF FUNCTIONAL FOODS
LA English
DT Article
DE Thrombosis; Anthocyanin; Obesity; Platelet function; Polyphenols
ID INHIBIT PLATELET-FUNCTION; METABOLIC SYNDROME; OXIDATIVE STRESS;
   RISK-FACTORS; CARDIOVASCULAR-DISEASE; SIGNALING PATHWAY;
   CONTROLLED-TRIAL; JUICE; CONSUMPTION; ACTIVATION
AB The aim was to evaluate the effect of anthocyanin (ACN) supplementation in reducing thrombogenesis and maintaining hemostasis in pro-thrombotic overweight and obese individuals. Twenty-six (M = 9, F = 17) overweight/obese (BMI > 25) individuals participated in this randomized, double-blind, placebo-controlled, crossover design dietary intervention trial. Volunteers consumed ACN (320 mg/day) or placebo capsules for 28-days followed by a two-week wash-out period. ACN supplementation inhibited adenosine diphosphate (ADP)-induced platelet, activation-related conformational change and degranulation by reducing PAC-1 expression by 12% and P-selectin expression by 9% respectively. ACN supplementation also alleviated thrombogenic progression by reducing monocyte-platelet aggregate formation by 29% and platelet endothelial cell adhesion molecule-1 (PECAM-1) expression by 21%. Platelet aggregation induced by ADP, collagen and arachidonic acid was reduced by 36%, 17%, and 24% respectively. ACN supplementation has the potential to reduce the risk of thrombosis in overweight/obese population by targeting specific pathways of platelet activation/aggregation and endothelial dysfunction associated leucocyte migration. (C) 2017 Elsevier Ltd. All rights reserved.
C1 [Thompson, Kiara; Santhakumar, Abishek Bommannan] Charles Sturt Univ, Sch Biomed Sci, Boorooma St, Wagga Wagga, NSW 2650, Australia.
   [Pederick, Wayne] QML Pathol, Rockhampton, Qld 4700, Australia.
   [Pederick, Wayne] Cent Queensland Univ, Sch Med & Appl Sci, Rockhampton, Qld 4701, Australia.
   [Singh, Indu] Griffith Univ, Sch Med Sci, Gold Coast 4215, Australia.
C3 Charles Sturt University; Central Queensland University; Griffith
   University; Griffith University - Gold Coast Campus
RP Santhakumar, AB (corresponding author), Charles Sturt Univ, Sch Biomed Sci, Boorooma St, Wagga Wagga, NSW 2650, Australia.
EM kiarathompson93@live.com; wayne.pederick@qml.com.au;
   i.singh@griffith.edu.au; asanthakumar@csu.edu.au
RI Santhakumar, Abishek/B-6700-2017
OI Thompson, Kiara/0000-0002-6104-3659; Singh, Indu/0000-0002-0498-4209
FU Central Queensland University, Queensland, Australia, New Staff Grant
FX This clinical trial was financially supported by the Central Queensland
   University, Queensland, Australia, New Staff Grant. The authors would
   like to thank Mr. Mitchell Thorpe, Ms. Holly Hosking, Ms. Alyssa Tyrrell
   and Mrs. Judy Couper for their technical assistance. The authors would
   also like to thank all the volunteers for their participation in this
   study.
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NR 42
TC 27
Z9 31
U1 1
U2 17
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1756-4646
J9 J FUNCT FOODS
JI J. Funct. Food.
PD MAY
PY 2017
VL 32
BP 131
EP 138
DI 10.1016/j.jff.2017.02.031
PG 8
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA ET4BU
UT WOS:000400224800015
DA 2025-06-11
ER

PT J
AU Hernandez-Rodas, MC
   Valenzuela, R
   Videla, LA
AF Catalina Hernandez-Rodas, Maria
   Valenzuela, Rodrigo
   Videla, Luis A.
TI Relevant Aspects of Nutritional and Dietary Interventions in
   Non-Alcoholic Fatty Liver Disease
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE NAFLD; lifestyle; diet; exercise; vitamins; amino acids; prebiotics;
   polyunsaturated fatty acids; polyphenols; medicinal plants
ID ATTENUATES HEPATIC STEATOSIS; KAPPA-B ACTIVATION; HIGH-PROTEIN DIET;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; CARDIOVASCULAR-DISEASE;
   OXIDATIVE STRESS; GUT MICROBIOTA; DOUBLE-BLIND; GREEN TEA
AB Non-alcoholic fatty liver disease (NAFLD) is the main cause of liver disease worldwide. NAFLD is linked to circumstances such as type 2 diabetes, insulin resistance, obesity, hyperlipidemia, and hypertension. Since the obesity figures and related comorbidities are increasing, NAFLD has turned into a liver problem that has become progressively more common. Currently, there is no effective drug therapy for NAFLD; therefore, interventions in lifestyles remain the first line of treatment. Bearing in mind that adherence rates to this type of treatment are poor, great efforts are currently focused on finding novel therapeutic agents for the prevention in the development of hepatic steatosis and its progression to nonalcoholic steatohepatitis and cirrhosis. This review presents a compilation of the scientific evidence found in the last years showing the results of interventions in lifestyle, diet, and behavioral therapies and research results in human, animal and cell models. Possible therapeutic agents ranging from supplementation with vitamins, amino acids, prebiotics, probiotics, symbiotics, polyunsaturated fatty acids and polyphenols to interventions with medicinal plants are analyzed.
C1 [Catalina Hernandez-Rodas, Maria; Valenzuela, Rodrigo] Univ Chile, Dept Nutr, Fac Med, Santiago 8380453, Chile.
   [Videla, Luis A.] Univ Chile, Mol & Clin Pharmacol Program, Inst Biomed Sci, Fac Med, Santiago 8380453, Chile.
C3 Universidad de Chile; Universidad de Chile
RP Valenzuela, R (corresponding author), Univ Chile, Dept Nutr, Fac Med, Santiago 8380453, Chile.
EM cata.hernandezr@gmail.com; rvalenzuelab@med.uchile.cl;
   lvidela@med.uchile.cl
RI Hernández-Rodas, María/ABG-5275-2021
OI Hernandez Rodas, Maria Catalina/0000-0001-9516-4056
FU Initiation FONDECYT (National Fund for Scientific and Technological
   Development) of Rodrigo Valenzuela, Department of Nutrition, Faculty of
   Medicine, Chile [11140174]; Enlaza-Mundos Program of the Mayor of
   Medellin (Colombia)-Agency for Higher Education of Medellin-SAPIENCIA
FX The authors are grateful to project (11140174) from Initiation FONDECYT
   (National Fund for Scientific and Technological Development) of Rodrigo
   Valenzuela, Department of Nutrition, Faculty of Medicine, Chile. And the
   Enlaza-Mundos Program of the Mayor of Medellin (Colombia)-Agency for
   Higher Education of Medellin-SAPIENCIA, for the support to co-finance
   postgraduate study abroad (Maria Catalina Hernandez-Rodas).
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NR 134
TC 114
Z9 118
U1 0
U2 35
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD OCT
PY 2015
VL 16
IS 10
BP 25168
EP 25198
DI 10.3390/ijms161025168
PG 31
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA CV4JD
UT WOS:000364232100109
PM 26512643
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Imig, JD
AF Imig, John D.
TI Eicosanoids and renal damage in cardiometabolic syndrome
SO EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY
LA English
DT Review
DE cytokines; epoxide hydrolase; epoxyeicosatrienoic acids; inflammation;
   kidney; obesity
ID NECROSIS-FACTOR-ALPHA; MONOCYTE CHEMOATTRACTANT PROTEIN-1;
   ANGIOTENSIN-II; ENDOTHELIAL DYSFUNCTION; EPOXIDE HYDROLASE;
   INSULIN-RESISTANCE; BLOOD-PRESSURE; OXIDATIVE STRESS; ADIPOSE-TISSUE;
   EPOXYEICOSATRIENOIC ACIDS
AB Background: Obesity, hypertension and Type 2 diabetes are major contributing factors to the increase in the number of patients that have chronic kidney disease. The clustering of visceral obesity and cardiovascular risk factors has been designated metabolic syndrome or cardiometabolic syndrome. Cardionnetabolic syndrome is associated with a complex systemic inflammatory state that has been implicated in medically important complications, including endothelial dysfunction. inflammation, endothelial dysfunction and insulin resistance are interrelated and have reciprocal relationships that link cardiovascular and metabolic diseases. Ultimately, cardiometabolic syndrome increases the risk for cardiovascular events and end-organ damage. Although the number of patients with cardiometabolic syndrome is escalating, therapeutic approaches have not been developed that provide protection to the kidney. Objective: The objective of this review is to provide an overview of the contribution of eicosanoids to renal damage in cardiometabolic syndrome. Results/conclusion: Eicosanoids are altered in cardiometabolic syndrome and contribute to the progression of renal injury. The antihypertensive and anti-inflammatory actions of epoxides and soluble epoxide hydrolase inhibitors make these attractive eicosanoid therapeutic targets for chronic kidney disease in patients with cardiometabolic syndrome.
C1 [Imig, John D.] Med Coll Georgia, Vasc Biol Ctr, Augusta, GA 30912 USA.
C3 University System of Georgia; Augusta University
RP Imig, JD (corresponding author), Med Coll Georgia, Vasc Biol Ctr, 1120 Fifteenth St, Augusta, GA 30912 USA.
OI Imig, John/0000-0002-9668-2899
FU NHLBI NIH HHS [R01 HL059699, HL 59699] Funding Source: Medline; NIDDK
   NIH HHS [DK 38826] Funding Source: Medline
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NR 108
TC 52
Z9 55
U1 0
U2 3
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1742-5255
EI 1744-7607
J9 EXPERT OPIN DRUG MET
JI Expert Opin. Drug Metab. Toxicol.
PD FEB
PY 2008
VL 4
IS 2
BP 165
EP 174
DI 10.1517/17425255.4.2.165
PG 10
WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology
GA 264GL
UT WOS:000253275600004
PM 18248310
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Axelsson, J
   Stenvinkel, P
AF Axelsson, Jonas
   Stenvinkel, Peter
TI Role of fat mass and adipokines in chronic kidney disease
SO CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION
LA English
DT Review
DE cardiovascular disease; chronic kidney disease; fat tissue; insulin
   resistance
ID SOLUBLE LEPTIN RECEPTORS; INSULIN-RESISTANCE; SERUM LEPTIN;
   ADIPOSE-TISSUE; BODY-FAT; SYMPATHETIC ACTIVITY; PLASMA ADIPONECTIN;
   METABOLIC SYNDROME; SKELETAL-MUSCLE; MESSENGER-RNA
AB Purpose of review
   As traditional risk factors cannot alone explain the high prevalence and incidence of cardiovascular disease in chronic kidney disease, the complex of insulin resistance, oxidative stress, and endothelial dysfunction has increasingly been studied as an important non-traditional risk factor. Recent studies show that the adipose tissue is a complex organ with pleiotropic functions far beyond the mere storage of energy. Fat tissue secretes a number of adipokines including leptin and adiponectin, as well as cytokines, such as resistin, visfatin, tumor-necrosis factor-a and interleukin-6.
   Recent findings
   Adipokine serum levels are markedly elevated in chronic kidney disease, likely due to a decreased renal excretion. Evidence suggests that these pluripotent signaling molecules may have multiple effects modulating insulin signaling, endothelial health and vascular outcome.
   Summary
   Fat tissue is a storage depot for energy and a source of circulating signaling molecules. It plays an important role in the catabolic uremic milieu, and has been linked to systemic inflammation and uremic anorexia. Further research is needed to investigate the complex interactions between adipokine signaling networks and its effects on vascular health and outcome in chronic kidney disease.
C1 [Axelsson, Jonas; Stenvinkel, Peter] Karolinska Inst, Dept Clin Sci Intervent & Technol, Stockholm, Sweden.
C3 Karolinska Institutet
RP Stenvinkel, P (corresponding author), Karolinska Inst, Dept Clin Sci Intervent & Technol, Stockholm, Sweden.
EM peter.stenvinkel@ki.se
RI Axelsson, Jonas/A-4167-2011
OI Stenvinkel, Peter/0000-0002-8785-4820
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NR 70
TC 48
Z9 52
U1 0
U2 8
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1062-4821
EI 1473-6543
J9 CURR OPIN NEPHROL HY
JI Curr. Opin. Nephrol. Hypertens.
PD JAN
PY 2008
VL 17
IS 1
BP 25
EP 31
DI 10.1097/MNH.0b013e3282f2905f
PG 7
WC Urology & Nephrology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology; Cardiovascular System & Cardiology
GA 265CM
UT WOS:000253336700004
PM 18090666
DA 2025-06-11
ER

PT J
AU Sun, ZH
   Liu, K
   Liang, CP
   Wen, L
   Wu, JJ
   Liu, XL
   Li, XF
AF Sun, Zihao
   Liu, Kai
   Liang, Chuipeng
   Wen, Lin
   Wu, Jijiao
   Liu, Xiaolian
   Li, Xiaofang
TI Diosmetin as a promising natural therapeutic agent: In vivo, in vitro
   mechanisms, and clinical studies
SO PHYTOTHERAPY RESEARCH
LA English
DT Review
DE anti-cancer; Diosmetin; in vitro; in vivo; pharmacokinetic; pharmacology
ID NF-KAPPA-B; ESTROGEN-RECEPTOR-BETA; ACTIVATED PROTEIN-KINASE;
   TLR4/NF-KAPPA-B SIGNALING PATHWAY; INDUCED INFLAMMATORY CHANGES;
   OXIDATIVE STRESS; TRANSCRIPTION FACTOR; METABOLIC SYNDROME; CELL-CYCLE;
   OSTEOCLAST DIFFERENTIATION
AB Diosmetin, a natural occurring flavonoid, is primarily found in citrus fruits, beans, and other plants. Diosmetin demonstrates a variety of pharmacological activities, including anticancer, antioxidant, anti-inflammatory, antibacterial, metabolic regulation, cardiovascular function improvement, estrogenic effects, and others. The process of literature search was done using PubMed, Web of Science and ClinicalTrials databases with search terms containing Diosmetin, content, anticancer, anti-inflammatory, antioxidant, pharmacological activity, pharmacokinetics, in vivo, and in vitro. The aim of this review is to summarize the in vivo, in vitro and clinical studies of Diosmetin over the last decade, focusing on studies related to its anticancer, anti-inflammatory, and antioxidant activities. It is found that DIO has significant therapeutic effects on skin and cardiovascular system diseases, and its research in pharmacokinetics and toxicology is summarized. It provides the latest information for researchers and points out the limitations of current research and areas that should be strengthened in future research, so as to facilitate the relevant scientific research and clinical application of DIO.
C1 [Sun, Zihao; Liu, Kai; Liang, Chuipeng; Wen, Lin; Wu, Jijiao; Liu, Xiaolian; Li, Xiaofang] Chengdu Univ Tradit Chinese Med, State Key Lab Southwestern Chinese Med Resources, Chengdu, Peoples R China.
   [Sun, Zihao; Liu, Kai; Liang, Chuipeng; Wen, Lin; Wu, Jijiao; Liu, Xiaolian; Li, Xiaofang] Chengdu Univ Tradit Chinese Med, Sch Pharm, Chengdu, Peoples R China.
   [Li, Xiaofang] Chengdu Univ Tradit Chinese Med, Sch Pharm, State Key Lab Southwestern Chinese Med Resources, Chengdu 611137, Peoples R China.
C3 Chengdu University of Traditional Chinese Medicine; Chengdu University
   of Traditional Chinese Medicine; Chengdu University of Traditional
   Chinese Medicine
RP Li, XF (corresponding author), Chengdu Univ Tradit Chinese Med, Sch Pharm, State Key Lab Southwestern Chinese Med Resources, Chengdu 611137, Peoples R China.
EM lixiaofang@cdutcm.edu.cn
OI Liang, Chuipeng/0009-0006-7930-4227; Sun, Zihao/0009-0001-3006-8546;
   xiaofang, li/0000-0002-0604-849X
FU Chengdu Municipal Science and Technology Program (Sichuan, China)
FX The author would like to thank Biorender for creating custom scientific
   figures 1388 ().
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NR 277
TC 8
Z9 8
U1 9
U2 25
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0951-418X
EI 1099-1573
J9 PHYTOTHER RES
JI Phytother. Res.
PD JUL
PY 2024
VL 38
IS 7
BP 3660
EP 3694
DI 10.1002/ptr.8214
EA MAY 2024
PG 35
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA YV7A3
UT WOS:001222993800001
PM 38748620
DA 2025-06-11
ER

PT J
AU Lan, HJ
   Wang, H
   Chen, C
   Hu, WL
   Ai, C
   Chen, L
   Teng, H
AF Lan, Haijing
   Wang, Hui
   Chen, Chong
   Hu, Wenlu
   Ai, Chao
   Chen, Lei
   Teng, Hui
TI Flavonoids and gastrointestinal health: single molecule for multiple
   roles
SO CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
LA English
DT Review
DE Dietary flavonoids; gastrointestinal health; gut microbiota; absorption;
   bioaccessibility
ID RED WINE POLYPHENOLS; LACTIC-ACID BACTERIA; GUT MICROBIOTA; FECAL
   MICROBIOTA; PHENOLIC-COMPOUNDS; DIETARY FIBER; INTESTINAL MICROBIOTA;
   METABOLIC SYNDROME; TEA POLYPHENOLS; GENE-EXPRESSION
AB Diet can be considered as one of the pivotal factors in regulating gastrointestinal health, and polyphenols widely distributed in human daily diet. The polyphenols and their metabolites playing a series of beneficial effects in human gastrointestinal tract that can regulate of the gut microbiota, increase intestinal barrier function, repair gastrointestinal mucosa, reduce oxidative stress, inhibit the secretion of inflammatory factors and regulating immune function, and their absorption and biotransformation mainly depend on the activity of intestinal microflora. However, little is known about the two-way interaction between polyphenols and intestinal microbiota. The objective of this review is to highlight the structure optimization and effect of flavonoids on intestinal flora, and discusses the mechanisms of dietary flavonoids regulating intestinal flora. The multiple effects of single molecule of flavonoids, and inter-dependence between the gut microbiota and polyphenol metabolites. Moreover, the protective effects of polyphenols on intestinal barrier function, and effects of interaction between plant polyphenols and macromolecules on gastrointestinal health. This review provided valuable insight that may be useful for better understanding the mechanism of the gastrointestinal health effects of polyphenols, and provide a scientific basis for their application as functional food.
C1 [Lan, Haijing; Wang, Hui; Chen, Chong; Hu, Wenlu; Ai, Chao; Chen, Lei; Teng, Hui] Guangdong Ocean Univ, Key Lab Adv Proc,Aquat Prod Guangdong Higher Educ, Coll Food Sci & Technol,Guangdong Prov Key Lab Aqu, Guangdong Prov Engn Technol Res Ctr Seafood,Guangd, Zhanjiang, Peoples R China.
C3 Guangdong Ocean University
RP Chen, L; Teng, H (corresponding author), Guangdong Ocean Univ, Key Lab Adv Proc,Aquat Prod Guangdong Higher Educ, Coll Food Sci & Technol,Guangdong Prov Key Lab Aqu, Guangdong Prov Engn Technol Res Ctr Seafood,Guangd, Zhanjiang, Peoples R China.
EM chenlei841114@hotmail.com; tenghui850610@126.com
RI chen, lei/Y-3308-2019; wang, hui/HJA-4306-2022; Ai, Chao/AAD-7914-2022;
   teng, h/MYQ-9731-2025
OI Wang, Hui/0000-0003-1450-6320
FU National Natural Science Foundation of China [NSFC] [32272315, 32072209,
   32061160477]; Natural Science Foundation of Guangdong Province
   [2022A1515010694]; Innovative Team Program of High Education of
   Guangdong Province [2021KCXTD021]
FX This work is supported by the National Natural Science Foundation of
   China [NSFC, Grant No. 32272315, 32072209, 32061160477], the Natural
   Science Foundation of Guangdong Province [2022A1515010694], the
   Innovative Team Program of High Education of Guangdong Province
   [2021KCXTD021].
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NR 198
TC 25
Z9 25
U1 24
U2 119
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1040-8398
EI 1549-7852
J9 CRIT REV FOOD SCI
JI Crit. Rev. Food Sci. Nutr.
PD NOV 28
PY 2024
VL 64
IS 30
BP 10987
EP 11005
DI 10.1080/10408398.2023.2230501
EA JUN 2023
PG 19
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA K4Y3A
UT WOS:001020316700001
PM 37409462
DA 2025-06-11
ER

PT J
AU Panda, C
   Varadharaj, S
   Voruganti, VS
AF Panda, Chinmayee
   Varadharaj, Saradhadevi
   Voruganti, Venkata Saroja
TI PUFA, genotypes and risk for cardiovascular disease
SO PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
LA English
DT Article
DE Genetic variants; Diet; Obesity; Cardiovascular disease; Inflammation;
   Oxidative stress
ID POLYUNSATURATED FATTY-ACIDS; FISH-OIL SUPPLEMENTATION; FADS1-FADS2
   GENE-CLUSTER; ALPHA-LINOLENIC ACID; INSULIN-RESISTANCE;
   OMEGA-3-FATTY-ACIDS SUPPLEMENTATION; MYOCARDIAL-INFARCTION; REINFARCTION
   TRIAL; METABOLIC SYNDROME; ARACHIDONIC-ACID
AB Polyunsaturated fatty acids (PUFAs) are long chain fatty acids that are characterized by the presence of more than one double bond. These include fatty acids such as omega-3-alpha-linolenic acid (ALA) and omega-6 -linoleic acid (LA) which can only be obtained from dietary sources and are therefore termed essential fatty acids. They contain the building blocks for dihomo-gamma-linolenic acid and arachidonic acid in the omega-6 family as well as eicosapentaenoic acid and docosahexaenoic acid in the omega-3 family. Both ALA and LA are important constituents of animal and plant cell membranes and are important components of anti-inflammatory and pro-inflammatory hormones and therefore, often modulate cellular immunity under chronic inflammatory states. The variation in physiological PUFA levels is under significant genetic influence, the fatty acid desaturase (FADS) genes being key regulators of PUFA metabolism. These genetic variants have been shown to alter fatty acid metabolism and influence the onset and progression of various metabolic conditions. This detailed review discusses the role of PUFAs, diet and genotypes in risk for cardiovascular diseases.
C1 [Panda, Chinmayee; Voruganti, Venkata Saroja] Univ North Carolina Chapel Hill, Dept Nutr, Rm 3150,500 Laureate Way, Kannapolis, NC 28081 USA.
   [Panda, Chinmayee; Voruganti, Venkata Saroja] Univ North Carolina Chapel Hill, Nutr Res Inst, Rm 3150,500 Laureate Way, Kannapolis, NC 28081 USA.
   [Panda, Chinmayee; Varadharaj, Saradhadevi] Stand Proc Inc, Palmyra, WI USA.
C3 University of North Carolina; University of North Carolina Chapel Hill;
   University of North Carolina; University of North Carolina Chapel Hill
RP Voruganti, VS (corresponding author), Univ North Carolina Chapel Hill, Dept Nutr, Rm 3150,500 Laureate Way, Kannapolis, NC 28081 USA.; Voruganti, VS (corresponding author), Univ North Carolina Chapel Hill, Nutr Res Inst, Rm 3150,500 Laureate Way, Kannapolis, NC 28081 USA.
EM saroja@unc.edu
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NR 160
TC 32
Z9 33
U1 0
U2 19
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0952-3278
EI 1532-2823
J9 PROSTAG LEUKOTR ESS
JI Prostaglandins Leukot. Essent. Fatty Acids
PD JAN
PY 2022
VL 176
AR 102377
DI 10.1016/j.plefa.2021.102377
EA DEC 2021
PG 10
WC Biochemistry & Molecular Biology; Cell Biology; Endocrinology &
   Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology; Endocrinology &
   Metabolism
GA YW5JC
UT WOS:000753448100006
PM 34915303
DA 2025-06-11
ER

PT J
AU Elshaghabee, FMF
   Rokana, N
   Panwar, H
   Heller, KJ
   Schrezenmeir, J
AF Elshaghabee, Fouad M. F.
   Rokana, Namita
   Panwar, Harsh
   Heller, Knut J.
   Schrezenmeir, Juergen
TI Probiotics for dietary management of non-alcoholic fatty liver disease
SO ENVIRONMENTAL CHEMISTRY LETTERS
LA English
DT Review
DE NAFLD; High fat diet; Metabolic syndrome; Gut microbiota; Probiotics
ID RHAMNOSUS-STRAIN-GG; GUT MICROBIOTA; DOUBLE-BLIND;
   BIFIDOBACTERIUM-ADOLESCENTIS; AKKERMANSIA-MUCINIPHILA; INTESTINAL
   BARRIER; HEPATIC STEATOSIS; TIGHT JUNCTION; OBESE CHILDREN; FRUCTOSE
AB Non-alcoholic fatty liver disease (NAFLD) is characterized by an increase in fat content of liver cells, which is independent from alcohol intake. Here, we review the impact of microbiota and diet on the pathogenesis of NAFLD and the present knowledge on the effect of probiotics for dietary management of NAFLD. The major points are the following: (1) dietary preference of a high fructose and/or high fat diet seems to be associated with NAFLD. (2) Different microbial metabolites, including short chain fatty acids and ethanol, are associated with increased levels of lipogenesis. (3) Ethanol is metabolized to acetaldehyde resulting in increased oxidative stress and consecutively in liver injury. (4) Ethanol may also impair gut barrier function, which may enable translocation of lipopolysaccharides from Gram-negative bacteria and, hence, further promote low grade inflammation in liver tissue. (5) Beneficial gut microbiota may counteract the pathogenesis of NAFLD through displacement of NAFLD promoting microbes, reduction of overall microbial ethanol production, promotion of gut barrier function and suppression of inflammatory cascades. Therefore, selective probiotic strains with proven efficacy for NAFLD management and validated safety can be considered as a promising approach for NAFLD management.
C1 [Elshaghabee, Fouad M. F.] Cairo Univ, Dept Dairy Sci, Fac Agr, Giza 12613, Egypt.
   [Rokana, Namita; Panwar, Harsh] GADVASU, Coll Dairy Sci & Technol, Dept Dairy Microbiol, Ludhiana, Punjab, India.
   [Heller, Knut J.] Fed Res Inst Nutr & Food, Max Rubner Inst, Dept Microbiol & Biotechnol, Kiel, Germany.
   [Schrezenmeir, Juergen] Johannes Gutenberg Univ Mainz, Med Clin, Mainz, Germany.
   [Schrezenmeir, Juergen] Kiel Innovat & Technol Ctr Kiel, Clin Res Ctr, Schauenburgerstr 16, D-24118 Kiel, Germany.
C3 Egyptian Knowledge Bank (EKB); Cairo University; Guru Angad Dev
   Veterinary & Animal Sciences University (GADVASU); Johannes Gutenberg
   University of Mainz
RP Schrezenmeir, J (corresponding author), Johannes Gutenberg Univ Mainz, Med Clin, Mainz, Germany.; Schrezenmeir, J (corresponding author), Kiel Innovat & Technol Ctr Kiel, Clin Res Ctr, Schauenburgerstr 16, D-24118 Kiel, Germany.
EM j.schrezenmeir@crc-kiel.de
RI Rokana, Namita/N-6761-2019; Elshaghabee, Fouad/ABG-8192-2020
OI Rokana, Namita/0000-0003-1057-9944; Elshaghabee,
   Fouad/0000-0002-9576-3945; Panwar, Harsh/0000-0003-4352-4229
FU DAAD
FX Funding was provided by DAAD (Grant No. Alumni grant).
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NR 100
TC 12
Z9 12
U1 2
U2 45
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1610-3653
EI 1610-3661
J9 ENVIRON CHEM LETT
JI Environ. Chem. Lett.
PD DEC
PY 2019
VL 17
IS 4
BP 1553
EP 1563
DI 10.1007/s10311-019-00896-8
PG 11
WC Chemistry, Multidisciplinary; Engineering, Environmental; Environmental
   Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Engineering; Environmental Sciences & Ecology
GA JL3GE
UT WOS:000495418400008
DA 2025-06-11
ER

PT J
AU Stram, AR
   Payne, RM
AF Stram, Amanda R.
   Payne, R. Mark
TI Post-translational modifications in mitochondria: protein signaling in
   the powerhouse
SO CELLULAR AND MOLECULAR LIFE SCIENCES
LA English
DT Review
DE Mitochondria; Metabolism; Post-translational modification; Acetylation
ID TYROSINE-PHOSPHORYLATED PROTEINS; SIRT3 DEACETYLATES; O-GLCNACYLATION;
   NITRIC-OXIDE; ISCHEMIA-REPERFUSION; OXIDATIVE STRESS; S-NITROSYLATION;
   ACETYL-COA; CROSS-TALK; CELL-DEATH
AB There is an intimate interplay between cellular metabolism and the pathophysiology of disease. Mitochondria are essential to maintaining and regulating metabolic function of cells and organs. Mitochondrial dysfunction is implicated in diverse diseases, such as cardiovascular disease, diabetes and metabolic syndrome, neurodegeneration, cancer, and aging. Multiple reversible post-translational protein modifications are located in the mitochondria that are responsive to nutrient availability and redox conditions, and which can act in protein-protein interactions to modify diverse mitochondrial functions. Included in this are physiologic redox signaling via reactive oxygen and nitrogen species, phosphorylation, O-GlcNAcylation, acetylation, and succinylation, among others. With the advent of mass proteomic screening techniques, there has been a vast increase in the array of known mitochondrial post-translational modifications and their protein targets. The functional significance of these processes in disease etiology, and the pathologic response to their disruption, are still under investigation. However, many of these reversible modifications act as regulatory mechanisms in mitochondria and show promise for mitochondrial-targeted therapeutic strategies. This review addresses the current knowledge of post-translational processing and signaling mechanisms in mitochondria, and their implications in health and disease.
C1 [Stram, Amanda R.] Indiana Univ Sch Med, Dept Surg, Indianapolis, IN 46202 USA.
   [Payne, R. Mark] Indiana Univ Sch Med, Dept Pediat, Indianapolis, IN 46202 USA.
   [Stram, Amanda R.; Payne, R. Mark] Indiana Univ Sch Med, Dept Cellular & Integrat Physiol, Indianapolis, IN 46202 USA.
   [Stram, Amanda R.; Payne, R. Mark] Indiana Univ Sch Med, Herman B Wells Ctr Pediat Res, 1044 W Walnut St,Room R4-302b, Indianapolis, IN 46202 USA.
C3 Indiana University System; Indiana University Bloomington; Indiana
   University System; Indiana University Bloomington; Indiana University
   System; Indiana University Bloomington; Indiana University System;
   Indiana University Bloomington
RP Payne, RM (corresponding author), Indiana Univ Sch Med, Dept Pediat, Indianapolis, IN 46202 USA.; Payne, RM (corresponding author), Indiana Univ Sch Med, Dept Cellular & Integrat Physiol, Indianapolis, IN 46202 USA.; Payne, RM (corresponding author), Indiana Univ Sch Med, Herman B Wells Ctr Pediat Res, 1044 W Walnut St,Room R4-302b, Indianapolis, IN 46202 USA.
EM rpayne@iu.edu
FU National Institutes of Health (NHLBI) [1F31HL126489-01A1]; Muscular
   Dystrophy Association (MDA); Friedreich's Ataxia Research Alliance
   (FARA)
FX This project was supported by grants from the National Institutes of
   Health (NHLBI) 1F31HL126489-01A1 to ARS, and the Muscular Dystrophy
   Association (MDA) and the Friedreich's Ataxia Research Alliance (FARA)
   to RMP.
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NR 146
TC 120
Z9 136
U1 2
U2 93
PU SPRINGER BASEL AG
PI BASEL
PA PICASSOPLATZ 4, BASEL, 4052, SWITZERLAND
SN 1420-682X
EI 1420-9071
J9 CELL MOL LIFE SCI
JI Cell. Mol. Life Sci.
PD NOV
PY 2016
VL 73
IS 21
BP 4063
EP 4073
DI 10.1007/s00018-016-2280-4
PG 11
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA DY5SW
UT WOS:000385164300006
PM 27233499
OA Green Published
DA 2025-06-11
ER

PT J
AU Takahashi, Y
   Sugimoto, K
   Soejima, Y
   Kumagai, A
   Koeda, T
   Shojo, A
   Nakagawa, K
   Harada, N
   Yamaji, R
   Inui, H
   Yamanouchi, T
   Fukusato, T
AF Takahashi, Yoshihisa
   Sugimoto, Keiichiro
   Soejima, Yurie
   Kumagai, Arisa
   Koeda, Tatsuki
   Shojo, Aiko
   Nakagawa, Kazuya
   Harada, Naoki
   Yamaji, Ryoichi
   Inui, Hiroshi
   Yamanouchi, Toshikazu
   Fukusato, Toshio
TI Inhibitory Effects of Eucalyptus and Banaba Leaf Extracts on
   Nonalcoholic Steatohepatitis Induced by a High-Fructose/High-Glucose
   Diet in Rats
SO BIOMED RESEARCH INTERNATIONAL
LA English
DT Article
ID FATTY LIVER-DISEASE; LIPOGENIC ENZYMES; SUCROSE
AB Nonalcoholic steatohepatitis (NASH) is a liver disease associated with metabolic syndrome. The aim of this work was to examine whether eucalyptus (Eucalyptus globulus) leaf extract (ELE) and banaba (Lagerstroemia speciosa L.) leaf extract (BLE) inhibited NASH induced by excessive ingestion of fructose in rats. Wistar rats were divided into four groups according to four distinct diets: starch diet (ST), high-fructose/high-glucose diet (FG), FG diet supplemented with ELE, or FG diet supplemented with BLE. All rats were killed after 5 weeks of treatment. Serum alanine aminotransferase and total cholesterol levels were significantly lower in the BLE group than in the FG group. Liver histopathology, including steatosis, lipogranulomas, and perisinusoidal fibrosis, was significantly attenuated in the ELE and BLE groups compared with the FG group. Levels of 2-thiobarbituric acid reactive substances (TBARS), which reflect oxidative injury to the liver, were significantly suppressed by ELE and BLE. Western blotting analysis indicated that interleukin-6 expression levels were significantly lower in the ELE and BLE groups than in the FG group. These results suggest that ELE and BLE reduced lipogenesis, oxidative stress, and inflammatory cytokine expression and thus inhibited NASH induced by excessive ingestion of fructose in rats.
C1 [Takahashi, Yoshihisa; Soejima, Yurie; Kumagai, Arisa; Fukusato, Toshio] Teikyo Univ, Sch Med, Dept Pathol, Tokyo 1738605, Japan.
   [Sugimoto, Keiichiro; Nakagawa, Kazuya] Nagaoka Perfumery Co Ltd, Res Dev Ctr, Ibaraki, Osaka 5670005, Japan.
   [Sugimoto, Keiichiro; Shojo, Aiko; Inui, Hiroshi] Osaka Prefecture Univ, Ctr Res & Dev Bioresources, Sakai, Osaka 5998531, Japan.
   [Koeda, Tatsuki; Harada, Naoki; Yamaji, Ryoichi] Osaka Prefecture Univ, Grad Sch Life & Environm Sci, Div Appl Life Sci, Sakai, Osaka 5998531, Japan.
   [Shojo, Aiko] Soai Univ, Fac Human Dev, Dept Nutr & Hlth, Suminoe Ku, Osaka 5590033, Japan.
   [Inui, Hiroshi] Osaka Prefecture Univ, Coll Hlth & Human Sci, Dept Clin Nutr, Habikino, Osaka 5838555, Japan.
   [Yamanouchi, Toshikazu] Teikyo Univ, Sch Med, Dept Internal Med, Tokyo 1738605, Japan.
C3 Teikyo University; Osaka Metropolitan University; Osaka Metropolitan
   University; Osaka Metropolitan University; Teikyo University
RP Takahashi, Y (corresponding author), Teikyo Univ, Sch Med, Dept Pathol, Tokyo 1738605, Japan.
EM ytakaha-tky@umin.ac.jp
RI Harada, Naoki/AAP-2868-2020; Soejima, Yurie/NGQ-7908-2025; Sugimoto,
   Keiichiro/M-5064-2015
OI Harada, Naoki/0000-0003-3846-388X; Vecchione,
   Andrea/0000-0002-5497-6856; Sugimoto, Keiichiro/0000-0003-2927-1237
FU JSPS KAKENHI [20193568, 23580181]; Grants-in-Aid for Scientific Research
   [23580181] Funding Source: KAKEN
FX This work was supported by JSPS KAKENHI Grants nos. 20193568 and
   23580181. The authors thank the Teikyo Academic Research Center for
   giving advice on statistical analysis.
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NR 33
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Z9 3
U1 0
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2314-6133
EI 2314-6141
J9 BIOMED RES INT
JI Biomed Res. Int.
PY 2015
VL 2015
AR 296207
DI 10.1155/2015/296207
PG 9
WC Biotechnology & Applied Microbiology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Research & Experimental Medicine
GA CH8PP
UT WOS:000354298700001
PM 26000287
OA hybrid, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Liang, FX
   Kume, S
   Koya, D
AF Liang, Fengxia
   Kume, Shinji
   Koya, Daisuke
TI SIRT1 and insulin resistance
SO NATURE REVIEWS ENDOCRINOLOGY
LA English
DT Review
ID ACTIVATED-RECEPTOR-GAMMA; MITOCHONDRIAL ROS PRODUCTION; TRANSCRIPTION
   FACTOR FOXO1; INDUCED OXIDATIVE STRESS; TYROSINE-PHOSPHATASE 1B;
   BETA-CELL FAILURE; HIGH-FAT DIET; GENE-EXPRESSION; GLUCOSE; ADIPONECTIN
AB Sirtuin 1 (SIRT1), the mammalian homolog of SIR2, was originally identified as a NAD-dependent histone deacetylase, the activity of which is closely associated with lifespan under calorie restriction. Growing evidence suggests that SIRT1 regulates glucose or lipid metabolism through its deacetylase activity for over two dozen known substrates, and has a positive role in the metabolic pathway through its direct or indirect involvement in insulin signaling. SIRT1 stimulates a glucose-dependent insulin secretion from pancreatic beta cells, and directly stimulates insulin signaling pathways in insulin-sensitive organs. Furthermore, SIRT1 regulates adiponectin secretion, inflammatory responses, gluconeogenesis, and levels of reactive oxygen species, which together contribute to the development of insulin resistance. Moreover, overexpression of SIRT1 and several SIRT1 activators has beneficial effects on glucose homeostasis and insulin sensitivity in obese mice models. These findings suggest that SIRT1 might be a new therapeutic target for the prevention of disease related to insulin resistance, such as metabolic syndrome and diabetes mellitus, although direct evidence from clinical studies in humans is needed to prove this possibility. in this review, we discuss the potential role and therapeutic promise of SIRT1 in insulin resistance on the basis of the latest experimental studies.
C1 [Liang, Fengxia; Koya, Daisuke] Kanazawa Med Univ, Dept Endocrinol & Metab, Kanazawa, Ishikawa 9200293, Japan.
   [Kume, Shinji] Shiga Univ Med Sci, Dept Med, Shiga, Japan.
C3 Kanazawa Medical University; Shiga University of Medical Science
RP Koya, D (corresponding author), Kanazawa Med Univ, Dept Endocrinol & Metab, Kanazawa, Ishikawa 9200293, Japan.
EM koya0516@kanazawa-med.ac.jp
RI Liang, Fenghua/HHM-3798-2022; Koya, Daisuke/J-3257-2014
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NR 60
TC 313
Z9 340
U1 1
U2 44
PU NATURE RESEARCH
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 1759-5029
EI 1759-5037
J9 NAT REV ENDOCRINOL
JI Nat. Rev. Endocrinol.
PD JUL
PY 2009
VL 5
IS 7
BP 367
EP 373
DI 10.1038/nrendo.2009.101
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 460RM
UT WOS:000267204800006
PM 19455179
DA 2025-06-11
ER

PT J
AU Gersch, C
   Palii, SP
   Kim, KM
   Angerhofer, A
   Johnson, RJ
   Henderson, GN
AF Gersch, Christine
   Palii, Sergiu P.
   Kim, Kyung Mee
   Angerhofer, Alexander
   Johnson, Richard J.
   Henderson, George N.
TI Inactivation of nitric oxide by uric acid
SO NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
LA English
DT Article
DE uric acid; nitric oxide; cardiovascular disease; endothelial
   dysfunction; 6-aminouracil; glutathione
ID HYPERURICEMIA; THIOLS; COPPER; PEROXYNITRITE; NITROSATION; ANTIOXIDANT;
   PROOXIDANT; OXIDATION; SYNTHASE; PLASMA
AB The 1980 identification of nitric oxide (NO) as an endothelial cell-derived relaxing factor resulted in an unprecedented biomedical research of NO and established NO as one of the most important cardiovascular, nervous and immune system regulatory molecule. A reduction in endothelial cell NO levels leading to endothelial dysfunction has been identified as a key pathogenic event preceding the development of hypertension, metabolic syndrome, and cardiovascular disease. The reduction in endothelial NO in cardiovascular disease has been attributed to the action of oxidants that either directly react with NO or uncouple its substrate enzyme. In this report, we demonstrate that uric acid (UA), the most abundant antioxidant in plasma, reacts directly with NO in a rapid irreversible reaction resulting in the formation of 6-aminouracil and depletion of NO. We further show that this reaction occurs preferentially with NO even in the presence of oxidants peroxynitrite and hydrogen peroxide and that the reaction is at least partially blocked by glutathione. This study shows a potential mechanism by which UA may deplete NO and cause endothelial dysfunction, particularly under conditions of oxidative stress in which UA is elevated and intracellular glutathione is depleted.
C1 [Gersch, Christine; Palii, Sergiu P.; Kim, Kyung Mee; Johnson, Richard J.; Henderson, George N.] Univ Florida, Div Nephrol & Hypertens, Dept Med, Gainesville, FL 32610 USA.
   [Angerhofer, Alexander] Univ Florida, Coll Liberal Arts & Sci, Dept Chem, Gainesville, FL 32610 USA.
   [Henderson, George N.] Univ Florida, Dept Med, Div Endocrinol & Metab, Gainesville, FL 32610 USA.
   [Henderson, George N.] Univ Florida, Gen Clin Res Ctr, Gainesville, FL 32610 USA.
C3 State University System of Florida; University of Florida; State
   University System of Florida; University of Florida; State University
   System of Florida; University of Florida; State University System of
   Florida; University of Florida
RP Henderson, GN (corresponding author), Univ Florida, Div Nephrol, Box 100224, Gainesville, FL 32610 USA.
EM hendegn@medicine.ufl.edu
RI Angerhofer, Alexander/E-3143-2010
OI Angerhofer, Alexander/0000-0002-8580-6024
FU NCRR NIH HHS [M01 RR000082, MO1-RR00082] Funding Source: Medline; NHLBI
   NIH HHS [R01 HL068607, HL-68607] Funding Source: Medline; NIDDK NIH HHS
   [DK-52121, R01 DK052121] Funding Source: Medline
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NR 26
TC 202
Z9 224
U1 0
U2 26
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1525-7770
EI 1532-2335
J9 NUCLEOS NUCLEOT NUCL
JI Nucleosides Nucleotides Nucleic Acids
PY 2008
VL 27
IS 8
BP 967
EP 978
DI 10.1080/15257770802257952
PG 12
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 336NN
UT WOS:000258371000005
PM 18696365
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Fardoun, RZ
AF Fardoun, Riham Zein
TI Carvedilol versus cardioselective β-blockers for the treatment of
   hypertension in patients with type 2 diabetes mellitus
SO PHARMACOTHERAPY
LA English
DT Review
DE type 2 diabetes mellitus; hypertension; carvedilol; beta-blocker;
   antioxidant; metabolic syndrome; cardiovascular risk
ID OXIDATIVE STRESS; BLOOD-PRESSURE; HEART-FAILURE; INSULIN; DYSFUNCTION;
   METOPROLOL; DRUG
AB Treatment with beta-blockers is recommended to achieve and maintain adequate blood pressure control in patients with hypertension, and these agents have been shown to decrease cardiovascular risk factors in patients with both hypertension and type 2 diabetes mellitus. However, beta-blocker therapy also may worsen glycemic and lipidemic control and may lead to microalbuminuria. A recent study showed a better metabolic profile with carvedilol than with metoprolol in patients with both type 2 diabetes and hypertension in the presence of renin-angiotensin system blockade. This beneficial effect on metabolic components has been proposed as attributable to carvedilol's alpha-blocking effects or antioxidant properties. In this article, the pathophysiology of hypertension and type 2 diabetes and the association between them are reviewed, the pharmacologic properties of carvedilol are discussed, and clinical studies in the literature comparing carvedilol with selective beta-blockers in patients with both type 2 diabetes and hypertension are identified and evaluated. This information should be useful to practitioners when selecting the optimum P-blocker for treating hypertension in patients with type 2 diabetes.
C1 Univ Houston, Coll Pharm, Heart & Kidney Inst, Houston, TX 77204 USA.
C3 University of Houston System; University of Houston
RP Fardoun, RZ (corresponding author), Univ Houston, Coll Pharm, Heart & Kidney Inst, 4800 Calhoun St, Houston, TX 77204 USA.
EM rihamfardoun@hotmail.com
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NR 46
TC 4
Z9 5
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0277-0008
EI 1875-9114
J9 PHARMACOTHERAPY
JI Pharmacotherapy
PD OCT
PY 2006
VL 26
IS 10
BP 1491
EP 1500
DI 10.1592/phco.26.10.1491
PG 10
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 090RE
UT WOS:000240967800014
PM 16999659
DA 2025-06-11
ER

PT J
AU Kushkestani, M
   Parvani, M
   Ghafari, M
   Avazpoor, Z
AF Kushkestani, Mehdi
   Parvani, Mohsen
   Ghafari, Mahmood
   Avazpoor, Zahra
TI The role of exercise and physical activity on aging-related diseases and
   geriatric syndromes
SO SPORT TK-REVISTA EUROAMERICANA DE CIENCIAS DEL DEPORTE
LA English
DT Article
DE Aging; Cardiovascular diseases; Exercise; Geriatric syndrome;
   Hypertension; Physical activity
ID OLDER-ADULTS; ARTERIAL STIFFNESS; METABOLIC SYNDROME; OXIDATIVE STRESS;
   INTENSITY; FALLS; METAANALYSIS; ASSOCIATION; MORTALITY
AB Aging is a complex process of physiological and social changes that leads to various diseases. The number of elderly people in the world is increasing dramatically and it should be noted that rapid population aging represents a major public health burden. On the other hand, providing an appropriate and low-cost approach to control and prevent complications such as chronic diseases, physical dysfunction, and the geriatric syndrome is necessary. Also, numerous studies have shown that participation in physical activity and exercise training reduces the incidence of dysfunctional capacity, cardiovascular and metabolic disease, as well as the premature death rate in older adults. After plenty of precise observations about the role of exercise on aging-related diseases and geriatric syndromes articles, the benefits of exercise and physical activity in older adults will be more tangible. Therefore, the first purpose of the present review was to investigate the mechanisms of PA and exercises that are involved in the prevention of aging-related diseases and GS using current evidence (from 2015 onwards). Also, the purpose of this study was to provide an exercise guideline (aerobic and resistance training) based on recent evidence (from 2015 onwards).
C1 [Kushkestani, Mehdi; Parvani, Mohsen; Ghafari, Mahmood] Allameh Tabatabai Univ, Fac Phys Educ & Sport Sci, Tehran, Iran.
   [Avazpoor, Zahra] Univ Tehran, Fac Phys Educ & Sport Sci, Tehran, Iran.
C3 Allameh Tabataba'i University; University of Tehran
RP Kushkestani, M (corresponding author), Allameh Tabatabai Univ, Fac Phys Educ & Sport Sci, Tehran, Iran.
EM mehdi.kushk@gmail.com
RI Parvani, Mohsen/KRP-0863-2024
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NR 110
TC 13
Z9 13
U1 2
U2 8
PU UNIV MURCIA
PI Murcia
PA Edificio Pleiades Campus de Espinardo, Murcia, 30071, SPAIN
SN 2340-8812
J9 SPORT TK
JI Sport TK
PD JAN
PY 2022
VL 11
PG 31
WC Sport Sciences
WE Emerging Sources Citation Index (ESCI)
SC Sport Sciences
GA YE0EM
UT WOS:000740805800007
DA 2025-06-11
ER

PT J
AU Cheng, FE
   Ge, XH
   Zhang, Y
   Li, J
   Yan, SQ
   Li, YL
   Wang, M
AF Cheng, Feier
   Ge, Xinhui
   Zhang, Yao
   Li, Jia
   Yan, Shaoqing
   Li, Yunlong
   Wang, Min
TI Quercetin and d-chiro-inositol combined alleviate hepatic insulin
   resistance
SO FOOD BIOSCIENCE
LA English
DT Article
DE Quercetin; D-chiro-inositol; Liver; Insulin resistance; C57BL/6J mice
ID METABOLIC SYNDROME; OXIDATIVE STRESS; FATTY LIVER; STEATOSIS; RECEPTOR;
   MODELS
AB The hypoglycemic effects and underlying molecular mechanisms of combining two dietary compounds, quercetin (Que) and d-chiro-inositol (DCI) on hepatic insulin resistance in C57BL/6J mice that were fed a high fat diet and saturated palmitic acid (PA)-treated hepatocytes were studied. Catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPx) are important antioxidant enzymes. Insufficient secretion of these enzymes will inhibit the normal phosphorylation of insulin receptors in the liver, thereby limiting the transmission of insulin signals and producing insulin resistance. The results showed that QD (both Que and DCI) led to the recovery of the activity of CAT, SOD, GPx, suggesting that QD was helpful in preventing mice hepatic insulin resistance. In PA-induced human hepatoma cells (HepG2), QD improved the antioxidant level in cells. The fluoroimmunoassay showed that QD effectively reduced the translocation of protein kinase Cc to cell membranes in the HepG2. Western blotting results suggested that QD increased the signal transduction in the IRS-2/PI3K/Akt/FoxO1 pathway. Overall, these results showed that the combination of 5 mu mol Que and 5 mu mol DCI ameliorated high fat diet-induced hepatic insulin resistance.
C1 [Cheng, Feier; Ge, Xinhui; Zhang, Yao; Li, Jia; Yan, Shaoqing; Wang, Min] Northwest Agr & Forest Univ, Coll Food Sci & Engn, Yangling 712100, Shaanxi, Peoples R China.
   [Li, Yunlong] Shanxi Acad Agr Sci, Inst Agr Prod Proc, Taiyuan 030031, Shanxi, Peoples R China.
   [Wang, Min] Shaanxi Key Lab Nat Prod & Chem Biol, Yangling 712100, Shaanxi, Peoples R China.
C3 Northwest A&F University - China; Shanxi Agricultural University
RP Wang, M (corresponding author), Northwest Agr & Forest Univ, Coll Food Sci & Engn, Yangling 712100, Shaanxi, Peoples R China.
EM wangmin20050606@163.com
RI Li（李）, Yunlong（云龙）/AAM-3787-2020; Zhang, Yaoyao/GWD-0693-2022
FU Earmarked Fund for the China Agriculture Research System [CARS-08-D2-01]
FX Thanks to Prof. Xianyong Lan for his guidance in the design and specific
   operation of the entire experiment in the College of Animal Science and
   Technology, Northwest A&F University, China. The study was supported by
   the Earmarked Fund for the China Agriculture Research System (Grant No.
   CARS-08-D2-01) .
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NR 48
TC 2
Z9 2
U1 4
U2 14
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2212-4292
EI 2212-4306
J9 FOOD BIOSCI
JI Food Biosci.
PD OCT
PY 2021
VL 43
AR 101255
DI 10.1016/j.fbio.2021.101255
EA JUL 2021
PG 11
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA WK1IF
UT WOS:000709486000011
DA 2025-06-11
ER

PT J
AU Martins, GR
   do Amaral, FRL
   Brum, FL
   Mohana-Borges, R
   de Moura, SST
   Ferreira, FA
   Sangenito, LS
   Santos, ALS
   Figueiredo, NG
   da Silva, AS
AF Martins, Gabriel R.
   do Amaral, Felipe Rafael L.
   Brum, Felipe L.
   Mohana-Borges, Ronaldo
   de Moura, Sayonara S. T.
   Ferreira, Fabienne A.
   Sangenito, Leandro S.
   Santos, Andre L. S.
   Figueiredo, Natalia G.
   da Silva, Ayla Sant'Ana
TI Chemical characterization, antioxidant and antimicrobial activities of
   acai seed (Euterpe oleracea Mart.) extracts containing A- and
   B-type procyanidins
SO LWT-FOOD SCIENCE AND TECHNOLOGY
LA English
DT Article
DE Acai seeds; Polyphenols; Mass spectrometry imaging; Antioxidant assays;
   Antimicrobial analysis
ID MEDICINAL-PLANTS; GRAPE JUICE; IN-VITRO; PROANTHOCYANIDINS; TANNINS;
   PHENOLICS; CAPACITY; POLYPHENOLS; BIOACTIVITY; ASSAY
AB Acai seed extracts are reported for containing polyphenols with pharmacological properties against inflammation, hypertension, and metabolic syndrome. However, presently, those seeds accumulate as waste, causing environmental problems. Therefore, we aimed to characterize the polyphenol profile of acai seed extracts to investigate its composition and biological effects. Multiple techniques were used for the identification of the extract's metabolites, such as HPLC, mass spectrometry, and mass spectrometry imaging (MALDI-IMS). The extract was majorly composed of B-type and A-type oligomeric procyanidins with a mean degree of polymerization of 11.4 (>3000 Da), formed by catechin and epicatechin as starter and extension subunits, respectively. MALDI-IMS confirmed, for the first time, the presence of A-type procyanidins in the seed's tegument. The extract was not cytotoxic to THP1 (macrophage cell line) and LLC-MK2 (epithelial cell) and, moreover, it efficiently protected macrophages from oxidative stress, which correlated to its high antioxidant capacity, confirmed by DPPH, TEAC and ORAC methods. Additionally, the extract presented antimicrobial activity against gram-positive bacterial strains and Candida albicans. These data indicate the potential use of seed extracts for cosmetic and pharmaceutical formulations.
C1 [Martins, Gabriel R.; do Amaral, Felipe Rafael L.; Figueiredo, Natalia G.; da Silva, Ayla Sant'Ana] Minist Ciencia Tecnol & Inovacao, Inst Nacl Tecnol, BR-20081312 Rio De Janeiro, Brazil.
   [Brum, Felipe L.; Mohana-Borges, Ronaldo] Univ Fed Rio de Janeiro, Ctr Espectrometria Massas Biomol CEMBIO, Inst Biofis Carlos Chagas Filho, BR-21941902 Rio De Janeiro, Brazil.
   [de Moura, Sayonara S. T.; Ferreira, Fabienne A.] Univ Fed Santa Catarina, Lab Genet Mol Bacterias, Dept Microbiol Imunol & Parasitol, BR-88040900 Florianopolis, SC, Brazil.
   [Sangenito, Leandro S.; Santos, Andre L. S.] Univ Fed Rio de Janeiro, Inst Microbiol Paulo Goes, BR-21941901 Rio De Janeiro, Brazil.
   [Santos, Andre L. S.; da Silva, Ayla Sant'Ana] Univ Fed Rio de Janeiro, Dept Bioquim, BR-21941909 Rio De Janeiro, Brazil.
C3 Universidade Federal do Rio de Janeiro; Universidade Federal de Santa
   Catarina (UFSC); Universidade Federal do Rio de Janeiro; Universidade
   Federal do Rio de Janeiro
RP da Silva, AS (corresponding author), Minist Ciencia Tecnol & Inovacao, Inst Nacl Tecnol, BR-20081312 Rio De Janeiro, Brazil.
EM ayla.santana@int.gov.br
RI Borges, Ronaldo/C-5575-2013; Moura, Sayonara/HRD-8717-2023; Ferreira,
   Fabienne/AAI-8489-2021; Santos, André/Z-5853-2019; Sant'Ana da Silva,
   Ayla/A-5922-2012; Rocha Martins, Gabriel/H-4018-2018; Ferreira,
   Fabienne/D-4345-2019
OI Brum, Felipe Lopes/0000-0003-1851-6331; Sant'Ana da Silva,
   Ayla/0000-0001-8466-9390; Rocha Martins, Gabriel/0000-0003-0469-1841;
   Ferreira, Fabienne/0000-0002-6444-6007
FU Coordination for the Improvement of Higher Education Personnel (CAPES)
   [Serra-1708-15009];  [AUXPE 0415/2016]
FX Serrapilheira Institute, grant number Serra-1708-15009; Coordination for
   the Improvement of Higher Education Personnel (CAPES), grant number
   AUXPE 0415/2016.
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NR 52
TC 54
Z9 57
U1 9
U2 61
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0023-6438
EI 1096-1127
J9 LWT-FOOD SCI TECHNOL
JI LWT-Food Sci. Technol.
PD OCT
PY 2020
VL 132
AR 109830
DI 10.1016/j.lwt.2020.109830
PG 11
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA NY9DH
UT WOS:000576684000006
OA Bronze
DA 2025-06-11
ER

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   Aschner, Michael
   Skalny, Anatoly, V
TI Selenium and Selenoproteins in Adipose Tissue Physiology and Obesity
SO BIOMOLECULES
LA English
DT Review
DE selenium; selenoprotein; adipocyte; adipogenesis; obesity
ID GENE-EXPRESSION PROFILES; CHLORO-DIPHENYL DISELENIDE;
   GLUTATHIONE-PEROXIDASE 3; OXIDATIVE STRESS; HIGH-FAT; DIETARY SELENIUM;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; SERUM CONCENTRATIONS; BARIATRIC
   SURGERY
AB Selenium (Se) homeostasis is tightly related to carbohydrate and lipid metabolism, but its possible roles in obesity development and in adipocyte metabolism are unclear. The objective of the present study is to review the current data on Se status in obesity and to discuss the interference between Se and selenoprotein metabolism in adipocyte physiology and obesity pathogenesis. The overview and meta-analysis of the studies on blood Se and selenoprotein P (SELENOP) levels, as well as glutathione peroxidase (GPX) activity in obese subjects, have yielded heterogenous and even conflicting results. Laboratory studies demonstrate that Se may modulate preadipocyte proliferation and adipogenic differentiation, and also interfere with insulin signaling, and regulate lipolysis. Knockout models have demonstrated that the selenoprotein machinery, including endoplasmic reticulum-resident selenoproteins together with GPXs and thioredoxin reductases (TXNRDs), are tightly related to adipocyte development and functioning. In conclusion, Se and selenoproteins appear to play an essential role in adipose tissue physiology, although human data are inconsistent. Taken together, these findings do not support the utility of Se supplementation to prevent or alleviate obesity in humans. Further human and laboratory studies are required to elucidate associations between Se metabolism and obesity.
C1 [Tinkov, Alexey A.; Ajsuvakova, Olga P.; Skalny, Anatoly, V] Yaroslavl State Univ, Yaroslavl 150003, Russia.
   [Tinkov, Alexey A.; Skalnaya, Margarita G.; Aschner, Michael; Skalny, Anatoly, V] IM Sechenov First Moscow State Med Univ, Sechenov Univ, Moscow 119146, Russia.
   [Ajsuvakova, Olga P.] Russian Acad Sci, Fed Res Ctr Biol Syst & Agrotechnol, Orenburg 460000, Russia.
   [Filippini, Tommaso; Vinceti, Marco] Univ Modena & Reggio Emilia, Environm Genet & Nutr Epidemiol Res Ctr, CREAGEN, I-41121 Modena, Italy.
   [Zhou, Ji-Chang] Sun Yat Sen Univ, Sch Publ Hlth Shenzhen, Shenzhen 518100, Peoples R China.
   [Lei, Xin Gen] Cornell Univ, Dept Anim Sci, Ithaca, NY 14853 USA.
   [Gatiatulina, Eugenia R.] All Russian Res Inst Med & Aromat Plants VILAR, Moscow 117216, Russia.
   [Michalke, Bernhard] Helmholtz Zentrum Munchen, Ingolstadter Landstr 1, D-85764 Neuherberg, Germany.
   [Aschner, Michael] Albert Einstein Coll Med, Dept Mol Pharmacol, Bronx, NY 10461 USA.
C3 Yaroslavl State University; Sechenov First Moscow State Medical
   University; Russian Academy of Sciences; Federal Research Centre of
   Biological Systems & Agro-technologies of the Russian Academy of
   Sciences; Universita di Modena e Reggio Emilia; Sun Yat Sen University;
   Cornell University; All-Russian Research Institute of Medicinal &
   Aromatic Plants; Helmholtz Association; Helmholtz-Center Munich - German
   Research Center for Environmental Health; Yeshiva University; Montefiore
   Medical Center; Albert Einstein College of Medicine
RP Tinkov, AA (corresponding author), Yaroslavl State Univ, Yaroslavl 150003, Russia.; Tinkov, AA (corresponding author), IM Sechenov First Moscow State Med Univ, Sechenov Univ, Moscow 119146, Russia.
EM tinkov.a.a@gmail.com; oajsuvakova@gmail.com
RI Ajsuvakova, Olga/N-6595-2016; Aschner, Michael/ACO-6461-2022;
   Nikonorova, Eugenia/AAQ-5445-2020; Skalny, Anatoly/J-3953-2019; Tinkov,
   Alexey/H-5842-2016; Filippini, Tommaso/D-5023-2016; Vinceti,
   Marco/O-2509-2015
OI Michalke, Bernhard/0000-0001-6376-2588; Filippini,
   Tommaso/0000-0003-2100-0344; Nikonorova, Eugenia/0000-0002-6360-2194;
   Zhou, Ji-Chang/0000-0003-4177-614X; Vinceti, Marco/0000-0002-0551-2473
FU National Institute of Environmental Health Sciences (NIEHS) [R01
   ES10563, R01 ES020852, R01 ES07331]
FX MA was supported in part by grants from the National Institute of
   Environmental Health Sciences (NIEHS) R01 ES10563, R01 ES020852 and R01
   ES07331.
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NR 263
TC 81
Z9 82
U1 2
U2 32
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2218-273X
J9 BIOMOLECULES
JI Biomolecules
PD APR
PY 2020
VL 10
IS 4
AR 658
DI 10.3390/biom10040658
PG 31
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA LW9WG
UT WOS:000539492400162
PM 32344656
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Sampath, C
   Rashid, MR
   Sang, S
   Ahmedna, M
AF Sampath, Chethan
   Rashid, Muhammed Raihan
   Sang, Shengmin
   Ahmedna, Mohamed
TI Specific bioactive compounds in ginger and apple alleviate hyperglycemia
   in mice with high fat diet-induced obesity via Nrf2 mediated pathway
SO FOOD CHEMISTRY
LA English
DT Article
DE Advance glycation end-products; Phloretin; [6]-Gingerol; Nrf2; CML;
   RAGE; GSH
ID GLYCATION END-PRODUCTS; OXIDATIVE STRESS; METABOLIC SYNDROME;
   EPITHELIAL-CELLS; TEA POLYPHENOL; IN-VITRO; INSULIN; ACTIVATION;
   EXPRESSION; (-)-EPIGALLOCATECHIN-3-GALLATE
AB Prolonged hyperglycemia activates the formation of advanced glycation end-products (AGEs). Major dicarbonyl compounds such as methylglyoxal or glyoxal are found to be the main precursors of AGEs and N(epsilon)-(carboxymethyl)lysine (CML) found to be predominantly higher in the diabetic population. We hypothesized that phloretin from apple and [6]-gingerol from ginger inhibit formation of AGEs and suppress the receptor for advanced glycation end products (RAGE) via nuclear factor erythroid-2-related-factor-2 (Nrf2)-dependent pathway. Phloretin and [6]-gingerol were supplemented at two different doses to C57BL/6 mice on high fat diet or standard diet for a period of 17 weeks. Phloretin or [6]-gingerol supplementation significantly reduced plasma glucose, alanine aminotransferase, aspartate aminotransferase, AGEs and insulin levels. Phloretin and [6]-gingerol also decreased the levels of AGEs and CML levels, via Nrf2 pathway, enhancing GSH/GSSG ratio, heme oxygenase-1 and glyoxalase 1 in liver tissue. These results suggest that phloretin and [6]-gingerol are potential dietary compounds that can alleviate diabetes-induced complications. (C) 2017 Elsevier Ltd. All rights reserved.
C1 [Sampath, Chethan; Rashid, Muhammed Raihan; Ahmedna, Mohamed] Qatar Univ, Coll Hlth Sci, Dept Human Nutr, Doha, Qatar.
   [Sang, Shengmin] North Carolina Agr & Tech State Univ, Ctr Excellence Postharvest Technol, Greensboro, NC 28081 USA.
C3 Qatar University; University of North Carolina; North Carolina A&T State
   University
RP Ahmedna, M (corresponding author), Qatar Univ, Coll Hlth Sci, POB 2713, Doha, Qatar.
EM ahmedna@qu.edu.qa
RI Sampath, Chethan/AAX-7521-2020; Sang, Shengmin/AFK-9982-2022
FU NPRP grant from the Qatar National Research Fund (a member of Qatar
   Foundation) [NPRP 5-220-3-063]
FX This research was made possible by NPRP grant # NPRP 5-220-3-063 from
   the Qatar National Research Fund (a member of Qatar Foundation). The
   statements made herein are solely the responsibility of the authors. The
   authors would also like to thank Dr. Hamda Al-Naemi, and all the staff
   at Laboratory Animal Research Center, Qatar University for their
   constant support during the animal experiments.
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NR 43
TC 63
Z9 65
U1 1
U2 126
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0308-8146
EI 1873-7072
J9 FOOD CHEM
JI Food Chem.
PD JUL 1
PY 2017
VL 226
BP 79
EP 88
DI 10.1016/j.foodchem.2017.01.056
PG 10
WC Chemistry, Applied; Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Food Science & Technology; Nutrition & Dietetics
GA EN4DQ
UT WOS:000395958600011
PM 28254022
DA 2025-06-11
ER

PT J
AU de Guia, RM
   Rose, AJ
   Sommerfeld, A
   Seibert, O
   Strzoda, D
   Zota, A
   Feuchter, Y
   Krones-Herzig, A
   Sijmonsma, T
   Kirilov, M
   Sticht, C
   Gretz, N
   Dallinga-Thie, G
   Diederichs, S
   Klöting, N
   Blüher, M
   Diaz, MB
   Herzig, S
AF de Guia, Roldan M.
   Rose, Adam J.
   Sommerfeld, Anke
   Seibert, Oksana
   Strzoda, Daniela
   Zota, Annika
   Feuchter, Yvonne
   Krones-Herzig, Anja
   Sijmonsma, Tjeerd
   Kirilov, Milen
   Sticht, Carsten
   Gretz, Norbert
   Dallinga-Thie, Geesje
   Diederichs, Sven
   Kloeting, Nora
   Blueher, Matthias
   Diaz, Mauricio Berriel
   Herzig, Stephan
TI microRNA-379 couples glucocorticoid hormones to dysfunctional lipid
   homeostasis
SO EMBO JOURNAL
LA English
DT Article
DE glucocorticoid signalling; LDLR; LSR; miRNA-379; VLDL triglyceride
ID STIMULATED LIPOPROTEIN RECEPTOR; HEPARAN-SULFATE PROTEOGLYCANS;
   TRIGLYCERIDE-METABOLISM; KNOCKOUT MICE; LDL RECEPTOR; LIVER; CLEARANCE;
   HYPERLIPIDEMIA; CHOLESTEROL; SUPPRESSION
AB In mammals, glucocorticoids (GCs) and their intracellular receptor, the glucocorticoid receptor (GR), represent critical checkpoints in the endocrine control of energy homeostasis. Indeed, aberrant GC action is linked to severe metabolic stress conditions as seen in Cushing's syndrome, GC therapy and certain components of the Metabolic Syndrome, including obesity and insulin resistance. Here, we identify the hepatic induction of the mammalian conserved microRNA (miR)-379/410 genomic cluster as a key component of GC/GR-driven metabolic dysfunction. Particularly, miR-379 was up-regulated in mouse models of hyperglucocorticoidemia and obesity as well as human liver in a GC/GR-dependent manner. Hepatocyte-specific silencing of miR-379 substantially reduced circulating very-low-density lipoprotein (VLDL)-associated triglyceride (TG) levels in healthy mice and normalized aberrant lipid profiles in metabolically challenged animals, mediated through miR-379 effects on key receptors in hepatic TG re-uptake. As hepatic miR-379 levels were also correlated with GC and TG levels in human obese patients, the identification of a GC/GR-controlled miRNA cluster not only defines a novel layer of hormone-dependent metabolic control but also paves the way to alternative miRNA-based therapeutic approaches in metabolic dysfunction.
C1 [de Guia, Roldan M.; Rose, Adam J.; Sommerfeld, Anke; Seibert, Oksana; Strzoda, Daniela; Zota, Annika; Feuchter, Yvonne; Krones-Herzig, Anja; Sijmonsma, Tjeerd; Kirilov, Milen; Diaz, Mauricio Berriel; Herzig, Stephan] Heidelberg Univ, Ctr Mol Biol ZMBH, German Canc Res Ctr DKFZ Heidelberg, Joint Div Mol Metab Control,DKFZ ZMBH Alliance &, Heidelberg, Germany.
   [de Guia, Roldan M.; Rose, Adam J.; Sommerfeld, Anke; Seibert, Oksana; Strzoda, Daniela; Zota, Annika; Feuchter, Yvonne; Krones-Herzig, Anja; Sijmonsma, Tjeerd; Kirilov, Milen; Diaz, Mauricio Berriel; Herzig, Stephan] Heidelberg Univ, Univ Hosp, Heidelberg, Germany.
   [Sticht, Carsten; Gretz, Norbert] Heidelberg Univ, Klinikum Mannheim, Med Res Ctr, D-68167 Mannheim, Germany.
   [Dallinga-Thie, Geesje] AMC Amsterdam, Dept Vasc Med, Amsterdam, Netherlands.
   [Diederichs, Sven] DKFZ, Helmholtz Univ Grp Mol RNA Biol & Canc, Heidelberg, Germany.
   [Diederichs, Sven] Heidelberg Univ, Inst Pathol, Heidelberg, Germany.
   [Kloeting, Nora; Blueher, Matthias] Univ Leipzig, Dept Med, D-04109 Leipzig, Germany.
C3 Helmholtz Association; German Cancer Research Center (DKFZ); Ruprecht
   Karls University Heidelberg; Ruprecht Karls University Heidelberg;
   Ruprecht Karls University Heidelberg; University of Amsterdam; Academic
   Medical Center Amsterdam; Helmholtz Association; German Cancer Research
   Center (DKFZ); Ruprecht Karls University Heidelberg; Leipzig University
RP Herzig, S (corresponding author), Heidelberg Univ, Ctr Mol Biol ZMBH, German Canc Res Ctr DKFZ Heidelberg, Joint Div Mol Metab Control,DKFZ ZMBH Alliance &, Heidelberg, Germany.
EM s.herzig@dkfz.de
RI Herzig, Stephan/MDT-3563-2025; Rose, Adam/AAC-6274-2019; Diaz,
   Mauricio/AAF-8285-2021; De Guia, Roldan/AAL-8529-2020; Diederichs,
   Sven/J-6237-2012
OI Herzig, Stephan/0000-0003-3950-3652; Berriel Diaz,
   Mauricio/0000-0003-4670-919X; dallinga-thie, geesje/0000-0001-5412-5923;
   Diederichs, Sven/0000-0001-7901-4752; de Guia,
   Roldan/0000-0002-4239-2407; Rose, Adam/0000-0001-9132-8244
FU Deutsche Forschungsgemeinschaft [He3260/7-2]; Helmholtz Association
   (ICEMED, Metabolic Dysfunction)
FX We thank Carolyn Algire, Peter Angel, Johannes Backs, Alexander Ernst,
   Katharina Genreith, Adriano Maida, Maria Muciek, Anja Reimann, Michaela
   Schafer, Sigrid Stohr, Christian Stoy, Diana Tichy, Xiaoyue Wang, and
   Julia Winter for technical support as well as Marc Montminy and Tobias
   Schafmeier for advice on the manuscript. This work was supported by
   grants from the Deutsche Forschungsgemeinschaft (He3260/7-2) and the
   Helmholtz Association (ICEMED, Metabolic Dysfunction) to SH.
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NR 58
TC 37
Z9 43
U1 0
U2 24
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0261-4189
EI 1460-2075
J9 EMBO J
JI Embo J.
PD FEB 3
PY 2015
VL 34
IS 3
BP 344
EP 360
DI 10.15252/embj.201490464
PG 17
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA CB5VD
UT WOS:000349694800008
PM 25510864
OA Green Published
DA 2025-06-11
ER

PT J
AU Han, SH
   Quon, MJ
   Koh, KK
AF Han, SH
   Quon, MJ
   Koh, KK
TI Beneficial vascular and metabolic effects of peroxisome
   proliferator-activated receptor-α activators
SO HYPERTENSION
LA English
DT Review
DE fibrates; endothelium; adipose tissue; insulin resistance;
   cardiovascular diseases
ID DENSITY-LIPOPROTEIN CHOLESTEROL; CORONARY-ARTERY-DISEASE; NITRIC-OXIDE
   SYNTHASE; HUMAN ENDOTHELIAL-CELLS; PPAR-ALPHA; COMBINED HYPERLIPIDEMIA;
   POSTPRANDIAL LIPEMIA; INSULIN SENSITIVITY; VASOMOTOR FUNCTION; OXIDATIVE
   STRESS
AB Fibric acid is a synthetic ligand of the nuclear receptor peroxisome proliferator-activated receptor (PPAR)-alpha that is highly expressed in skeletal muscle and heart, where it promotes beta-oxidation of fatty acids to mediate hypolipidemic actions. PPAR-alpha regulates expression of key proteins involved in atherogenesis, vascular inflammation, plaque instability, and thrombosis. Thus, PPAR-alpha may exert direct antiatherogenic actions in the vascular wall. Endothelial dysfunction associated with the metabolic syndrome and other insulin-resistant states is characterized by impaired insulin-stimulated nitric oxide production from the endothelium and decreased blood flow to skeletal muscle. Thus, improvement in insulin sensitivity leads to improved endothelial function. This may be an additional mechanism whereby fibrates decrease the incidence of coronary heart disease. Adiponectin is a protein secreted specifically by adipose cells that may couple regulation of insulin sensitivity with energy metabolism and serve to link obesity with insulin resistance. In this review, we discuss the mechanisms underlying the vascular and metabolic effects of fibrates that may act synergistically to prevent or regress atherosclerosis and coronary heart disease.
C1 Gil Heart Ctr, Div Cardiol, Gachon Med Sch, Inchon 405760, South Korea.
   NIH, Diabet Unit, Clin Invest Lab, NCCAM, Bethesda, MD 20892 USA.
C3 Gachon University; National Institutes of Health (NIH) - USA; NIH
   National Center for Complementary & Alternative Medicine (NCCAM)
RP Gil Heart Ctr, Div Cardiol, Gachon Med Sch, 1198 Kuwol Dong, Inchon 405760, South Korea.
EM kwangk@ghil.com
RI Quon, Michael/B-1970-2008
OI QUON, MICHAEL/0000-0002-5289-3707; Quon, Michael/0000-0002-9601-9915
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NR 66
TC 86
Z9 92
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0194-911X
EI 1524-4563
J9 HYPERTENSION
JI Hypertension
PD NOV
PY 2005
VL 46
IS 5
BP 1086
EP 1092
DI 10.1161/01.HYP.0000187900.36455.4c
PG 7
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 987VG
UT WOS:000233544900003
PM 16230515
OA Bronze
DA 2025-06-11
ER

PT J
AU Asbaghi, O
   Moodi, V
   Neisi, A
   Shirinbakhshmasoleh, M
   Abedi, S
   Oskouie, FH
   Eslampour, E
   Ghaedi, E
   Miraghajani, M
AF Asbaghi, Omid
   Moodi, Vihan
   Neisi, Azadeh
   Shirinbakhshmasoleh, Mina
   Abedi, Sajjad
   Oskouie, Fatemeh Hosseini
   Eslampour, Elham
   Ghaedi, Ehsan
   Miraghajani, Maryam
TI The effect of almond intake on glycemic control: A systematic review and
   dose-response meta-analysis of randomized controlled trials
SO PHYTOTHERAPY RESEARCH
LA English
DT Review
DE almond; glycemic control; meta-analysis; nuts; systematic review
ID TYPE-2 DIABETES-MELLITUS; CARDIOVASCULAR RISK-FACTORS; POSTPRANDIAL
   GLYCEMIA; LIPID PROFILE; LONG-TERM; INSULIN-RESISTANCE; METABOLIC
   SYNDROME; OXIDATIVE STRESS; LDL-CHOLESTEROL; HEMOGLOBIN A1C
AB Number trials have evaluated the effect of almond intake on glycemic control in adults; however, the results remain equivocal. Therefore, the present meta-analysis aims to examine the effectiveness of almond intake on glycemic parameters. Online databases including PubMed, Scopus, ISI web of science, Embase, and Cochrane Library were searched up to August 2021 for trials that examined the effect of almond intake on glycemic control parameters including fasting blood sugar (FBS), insulin, HOMA-IR, and HbA1C. Treatment effects were expressed as mean difference (MD) and the standard deviation (SD) of outcomes. To estimate the overall effect of almond intake, we used the random-effects model. In total, 24 studies with 31 arms were included in our analysis. The meta-analysis revealed that almond intake did not significantly change the concentrations of FBS, HbA1c, insulin levels, and HOMA-IR. In conclusion, there is currently no convincing evidence that almonds have a clear beneficial effect on glycemic control. Future studies are needed before any confirmed conclusion could be drowned.
C1 [Asbaghi, Omid; Miraghajani, Maryam] Shahid Beheshti Univ Med Sci, Canc Res Ctr, Tehran, Iran.
   [Moodi, Vihan] Univ Tehran Med Sci, Sch Med, Tehran, Iran.
   [Neisi, Azadeh] Islamic Azad Univ, Dept Nutr, Sci & Res Branch, Tehran, Iran.
   [Shirinbakhshmasoleh, Mina; Abedi, Sajjad] Univ Tehran Med Sci, Fac Pharm, Tehran, Iran.
   [Oskouie, Fatemeh Hosseini] Shahid Beheshti Univ Med Sci, Fac Nutr & Food Technol, Natl Nutr & Food Technol Res Inst, Dept Clin Nutr & Dietet, Tehran, Iran.
   [Eslampour, Elham] Lorestan Univ Med Sci, Student Res Comm, Khorramabad, Iran.
   [Ghaedi, Ehsan] Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Cellular & Mol Nutr, Tehran, Iran.
   [Miraghajani, Maryam] Univ Nottingham, Sch Med, Early Life Res Unit, Acad Div Child Hlth Obstet & Gynaecol, Nottingham, England.
   [Miraghajani, Maryam] Univ Nottingham, Sch Med, Nottingham Digest Dis Ctr, Nottingham, England.
   [Miraghajani, Maryam] Univ Nottingham, Sch Med, Biomed Res Ctr, Nottingham, England.
C3 Shahid Beheshti University Medical Sciences; Tehran University of
   Medical Sciences; Islamic Azad University; Tehran University of Medical
   Sciences; Shahid Beheshti University Medical Sciences; Lorestan
   University of Medical Sciences; Tehran University of Medical Sciences;
   University of Nottingham; University of Nottingham; University of
   Nottingham
RP Miraghajani, M (corresponding author), Shahid Beheshti Univ Med Sci, Canc Res Ctr, Tehran, Iran.; Ghaedi, E (corresponding author), Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Cellular & Mol Nutr, Tehran, Iran.
EM ehsanghaedi073@gmail.com; ms.miraghajani@yahoo.com
RI Moodi, Vihan/AAF-7374-2020
OI Moodi, Vihan/0000-0002-5501-9089; Ghaedi, Ehsan/0000-0003-4095-1591;
   Miraghajani, Maryam/0000-0002-8265-0335
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NR 92
TC 7
Z9 7
U1 1
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0951-418X
EI 1099-1573
J9 PHYTOTHER RES
JI Phytother. Res.
PD JAN
PY 2022
VL 36
IS 1
BP 395
EP 414
DI 10.1002/ptr.7328
EA NOV 2021
PG 20
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA YJ6VJ
UT WOS:000723140200001
PM 34841609
DA 2025-06-11
ER

PT J
AU Kapravelou, G
   Martínez, R
   Perazzoli, G
   González, CS
   Llopis, J
   Cantarero, S
   Goua, M
   Bermano, G
   Prados, J
   Melguizo, C
   Aranda, P
   López-Jurado, M
   Porres, JM
AF Kapravelou, Garyfallia
   Martinez, Rosario
   Perazzoli, Gloria
   Sanchez Gonzalez, Cristina
   Llopis, Juan
   Cantarero, Samuel
   Goua, Marie
   Bermano, Giovanna
   Prados, Jose
   Melguizo, Consolacion
   Aranda, Pilar
   Lopez-Jurado, Maria
   Porres, Jesus M.
TI Germination Improves the Polyphenolic Profile and Functional Value of
   Mung Bean (Vigna radiataL.)
SO ANTIOXIDANTS
LA English
DT Article
DE mung bean; germination; polyphenols; antioxidant capacity;
   antiproliferative effect
ID FATTY LIVER-DISEASE; PEA PISUM-SATIVUM; GLYCINE-MAX L.; ANTIOXIDANT
   CAPACITY; METABOLIC SYNDROME; CHEMICAL-COMPOSITION; OXIDATIVE STRESS;
   MINERAL-CONTENT; LEGUMES; PROTEIN
AB The use of legumes as functional foods has gained increasing attention for the prevention and treatment of the so called non-communicable diseases that are highly prevalent worldwide. In this regard, biotechnological approaches for the enhancement of legumes' nutritional and functional value have been extensively employed. In the present study, the process of germination increased several parameters of mung bean (Vigna radiataL.) functionality, including extract yield, total phenolic content and in vitro antioxidant capacity. In addition, 3-day-germinated mung bean proved to be an interesting source of dietary essential minerals and exhibited a greater variety of polyphenolic compounds compared to raw mung bean. These properties resulted in enhanced cytoprotective features of the 3-day mung bean extracts against radical oxygen species in human colorectal (HT29) and monocyte (U937) cell lines. Moreover, the antiproliferative effects were tested in different colon cancer cell lines, T84 and drug-resistant HCT-18, as well as in a non-tumor colon CCD-18 line. Altogether, our results demonstrate that the germination process improves the mung bean's nutritional value and its potential as a functional food.
C1 [Kapravelou, Garyfallia; Martinez, Rosario; Sanchez Gonzalez, Cristina; Llopis, Juan; Aranda, Pilar; Lopez-Jurado, Maria; Porres, Jesus M.] Univ Granada, Biomed Res Ctr CIBM, Inst Nutr & Food Technol INyTA, Dept Physiol, Avda Conocimiento S-N, Granada 18100, Spain.
   [Perazzoli, Gloria; Prados, Jose; Melguizo, Consolacion] Univ Granada, Biomed Res Ctr CIBM, Inst Biopathol & Regenerat Med IBIMER, Biosanit Inst Granada IBS GRANADA, Avda Conocimiento S-N, Granada 18100, Spain.
   [Cantarero, Samuel] Univ Granada, Fac Farm, Sci Instrumentat Ctr CIC, Dept Mass Spectrometry, Campus Univ Cartuja S-N, Granada 18071, Spain.
   [Goua, Marie; Bermano, Giovanna] Robert Gordon Univ, Sch Pharm & Life Sci, Aberdeen AB10 7GJ, Scotland.
C3 University of Granada; University of Granada; Instituto de Investigacion
   Biosanitaria IBS Granada; University of Granada; Robert Gordon
   University
RP Porres, JM (corresponding author), Univ Granada, Biomed Res Ctr CIBM, Inst Nutr & Food Technol INyTA, Dept Physiol, Avda Conocimiento S-N, Granada 18100, Spain.
EM kapravelou@ugr.es; rosariomz@ugr.es; gperazzoli@ugr.es; crissg@ugr.es;
   jllopis@ugr.es; ascm@ugr.es; m.goua@rgu.ac.uk; g.bermano@rgu.ac.uk;
   jcprados@ugr.es; melguizo@ugr.es; paranda@ugr.es; mlopezj@ugr.es;
   jmporres@ugr.es
RI LLOPIS, juan/JQV-8992-2023; Perazzoli, Gloria/AAI-7350-2020; Goua,
   Marie/J-8104-2019; Sanchez Gonzalez, Cristina/Q-6219-2017; Martinez,
   Rosario/K-7712-2017; Cantarero Malagon, Antonio Samuel/C-3258-2017;
   Prados, Jose/J-7116-2017; Melguizo Alonso, Consolacion/E-9842-2016;
   Aranda Ramirez, Pilar/B-8037-2016; Porres Foulquie, Jesus
   Maria/B-6442-2018; Kapravelou, Garyfallia/K-8635-2017
OI Sanchez Gonzalez, Cristina/0000-0002-1044-4858; Goua,
   Marie/0000-0003-1609-4366; Martinez, Rosario/0000-0003-2032-1621;
   Cantarero Malagon, Antonio Samuel/0000-0002-3716-0070; Prados,
   Jose/0000-0003-4303-7746; Melguizo Alonso,
   Consolacion/0000-0003-3990-806X; Aranda Ramirez,
   Pilar/0000-0002-7982-1359; Porres Foulquie, Jesus
   Maria/0000-0001-5657-0764; Kapravelou, Garyfallia/0000-0001-8414-9723
FU University of Granada through Plan Propio [PSE/17/002]; Spanish Ministry
   of Science, Innovation and Universities; European Union
   [RTC-2017-6540-1, RTI-2018-100934-B-I00]; FEDER program
FX This research was funded by the University of Granada through project
   PSE/17/002 of Plan Propio, as well as the Spanish Ministry of Science,
   Innovation and Universities and the European Union through projects
   RTC-2017-6540-1, and RTI-2018-100934-B-I00 and the FEDER program,
   respectively. The funders had no role in study design, data collection
   and analysis, decision to publish, or preparation of the manuscript.
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NR 71
TC 26
Z9 27
U1 4
U2 58
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD AUG
PY 2020
VL 9
IS 8
AR 746
DI 10.3390/antiox9080746
PG 22
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA NH6SE
UT WOS:000564797300001
PM 32823688
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Gamboa-Gómez, CI
   Guerrero-Romero, F
   Aradillas-García, C
   Rodríguez-Morán, M
   Simental-Mendía, LE
AF Gamboa-Gomez, Claudia I.
   Guerrero-Romero, Fernando
   Aradillas-Garcia, Celia
   Rodriguez-Moran, Martha
   Simental-Mendia, Luis E.
TI The Fat-to-Lean Mass Ratio Is Associated with Hyperinsulinemia in
   Healthy Mexican Adolescents
SO JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION
LA English
DT Article
DE Fat mass; lean mass; insulin; hyperinsulinemia; adolescents
ID CARDIOVASCULAR RISK-FACTORS; BODY-FAT; DIAGNOSTIC PERFORMANCE; WAIST
   CIRCUMFERENCE; METABOLIC SYNDROME; OXIDATIVE STRESS; ADIPOSITY;
   INFLAMMATION; PERCENTAGE; GLUCOSE
AB Objective:To evaluate whether the Fat-to-Lean Mass (FyM) ratio is associated to hyperinsulinemia in healthy adolescents. Methods:Apparently healthy adolescents aged 10 to 15 years that according to sex, age, and percentiles of body fat percent, were included and allocated into the groups with elevated (body fat percent >= 85 percentile) and normal total body fat (body fat percent <85 percentile). The FyM ratio was calculated as total lean mass (kg)/total body fat (kg) and hyperinsulinemia was defined by fasting insulin levels >= 20 mu UI/mL. Results:A total of 1,299 adolescents, 665 (51.9%) girls and 634 (48.1%) boys, were enrolled and allocated into the groups with high (n = 439) and normal (n = 860) body fat. The FyM index remained significantly associated with hyperinsulinemia (OR 5.58;95%CI: 1.54-28.10) after logistic regression analysis adjusted by sex, age, body-weight, body mass index, and waist circumference. Conclusion:The FyM index is highly associated to the presence of hyperinsulinemia in adolescents, emerging as a useful tool from anthropometric measurements for identify insulin abnormalities.
C1 [Gamboa-Gomez, Claudia I.; Guerrero-Romero, Fernando; Rodriguez-Moran, Martha; Simental-Mendia, Luis E.] Inst Mexicano Seguro Social, Unidad Invest Biomed, Delegac Durango, Canoas100, Durango 34067, Dgo, Mexico.
   [Aradillas-Garcia, Celia] Univ San Luis Potosi, Fac Med, Hormone Lab, San Luis Potosi, San Luis Potosi, Mexico.
C3 Instituto Mexicano del Seguro Social; Universidad Autonoma de San Luis
   Potosi
RP Simental-Mendía, LE (corresponding author), Inst Mexicano Seguro Social, Unidad Invest Biomed, Delegac Durango, Canoas100, Durango 34067, Dgo, Mexico.
EM luis_simental81@hotmail.com
RI Garcia, Celia/B-5830-2014
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NR 32
TC 8
Z9 8
U1 0
U2 1
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 0731-5724
EI 1541-1087
J9 J AM COLL NUTR
JI J. Am. Coll. Nutr.
PD APR 3
PY 2021
VL 40
IS 3
BP 219
EP 223
DI 10.1080/07315724.2020.1752845
EA APR 2020
PG 5
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA RG8MA
UT WOS:000578711900001
PM 33044900
DA 2025-06-11
ER

PT J
AU Park, MH
   Lee, JK
   Kim, N
   Min, WK
   Lee, JE
   Kim, KT
   Akiyama, H
   Herzog, H
   Schuchman, EH
   Jin, HK
   Bae, JS
AF Park, Min Hee
   Lee, Jong Kil
   Kim, Namoh
   Min, Woo-Kie
   Lee, Jeong Eun
   Kim, Kyoung-Tae
   Akiyama, Haruhiko
   Herzog, Herbert
   Schuchman, Edward H.
   Jin, Hee Kyung
   Bae, Jae-Sung
TI Neuropeptide Y Induces Hematopoietic Stem/Progenitor Cell Mobilization
   by Regulating Matrix Metalloproteinase-9 Activity Through Y1 Receptor in
   Osteoblasts
SO STEM CELLS
LA English
DT Article
DE Neuropeptide Y; Bone marrow environment; Hematopoietic stem/progenitor
   cell; Mobilization; Bone loss
ID BONE-MARROW NICHE; MESENCHYMAL STEM-CELLS; METABOLIC SYNDROME;
   MACROPHAGES; SDF-1; MIGRATION; SYSTEM; STRESS; MICE; CYCLOPHOSPHAMIDE
AB Hematopoietic stem/progenitor cell (HSPC) mobilization is an essential homeostatic process regulated by the interaction of cellular and molecular components in bone marrow niches. It has been shown by others that neurotransmitters released from the sympathetic nervous system regulate HSPC egress from bone marrow to peripheral blood. In this study, we investigate the functional role of neuropeptide Y (NPY) on this process. NPY deficient mice had significantly impaired HSPC mobilization due to increased expression of HSPC maintenance factors by reduction of matrix metalloproteinase-9 (MMP-9) activity in bone marrow. Pharmacological or endogenous elevation of NPY led to decrease of HSPC maintenance factors expression by activating MMP-9 in osteoblasts, resulting in HSPC mobilization. Mice in which the Y1 receptor was deleted in osteoblasts did not exhibit HSPC mobilization by NPY. Furthermore, NPY treatment in ovariectomized mice caused reduction of bone loss due to HSPC mobilization. These results suggest a new role of NPY on HSPC mobilization, as well as the potential therapeutic application of this neuropeptide for stem cell-based therapy.
C1 [Park, Min Hee; Lee, Jong Kil; Kim, Namoh; Jin, Hee Kyung; Bae, Jae-Sung] Kyungpook Natl Univ, Stem Cell Neuroplast Res Grp, Daegu, South Korea.
   [Park, Min Hee; Lee, Jong Kil; Kim, Namoh; Bae, Jae-Sung] Kyungpook Natl Univ, Cell & Matrix Res Inst, Sch Med, Dept Physiol, Daegu, South Korea.
   [Park, Min Hee; Lee, Jong Kil; Kim, Namoh; Bae, Jae-Sung] Kyungpook Natl Univ, Dept Biomed Sci, Plus KNU Biomed Convergence Program BK21, Daegu, South Korea.
   [Min, Woo-Kie] Kyungpook Natl Univ, Dept Orthopaed Surg, Daegu, South Korea.
   [Lee, Jeong Eun] Kyungpook Natl Univ, Dept Radiat Oncol, Daegu, South Korea.
   [Kim, Kyoung-Tae] Kyungpook Natl Univ, Dept Neurosurg, Sch Med, Daegu, South Korea.
   [Jin, Hee Kyung] Kyungpook Natl Univ, Dept Lab Anim Med, Coll Vet Med, Daegu, South Korea.
   [Akiyama, Haruhiko] Kyoto Univ, Dept Orthopaed, Kyoto, Japan.
   [Herzog, Herbert] Garvan Inst Med Res, Neurosci Res Program, Neurosci Div, Sydney, NSW, Australia.
   [Schuchman, Edward H.] Icahn Sch Med Mt Sinai, Dept Genet & Genom Sci, New York, NY 10029 USA.
C3 Kyungpook National University (KNU); Kyungpook National University
   (KNU); Kyungpook National University (KNU); Kyungpook National
   University (KNU); Kyungpook National University (KNU); Kyungpook
   National University (KNU); Kyungpook National University (KNU); Kyoto
   University; Garvan Institute of Medical Research; Icahn School of
   Medicine at Mount Sinai
RP Bae, JS (corresponding author), Kyungpook Natl Univ, Sch Med, 680 Gukchaebosang Ro, Daegu 700842, South Korea.; Jin, HK (corresponding author), Kyungpook Natl Univ, Coll Vet Med, 80 Daehakro, Taegu 702701, South Korea.
EM hkjin@knu.ac.kr; jsbae@knu.ac.kr
RI Bae, Jae-sung/AAM-8663-2021; Kim, Young/T-8521-2019; Lee,
   Jong/AAK-8231-2020; Herzog, Herbert/B-8294-2008
OI Herzog, Herbert/0000-0002-1713-1029; Min, Woo-Kie/0000-0003-2079-5085
FU Korea Health Technology R&D Project through the Korea Health Industry
   Development Institute (KHIDI) - Ministry of Health & Welfare, Republic
   of Korea [HI14C1636]; Bio & Medical Technology Development Program of
   the National Research Foundation (NRF) of Korea - Ministry of Science,
   ICT & Future Planning, Republic of Korea [2011-0019356]
FX This work was supported by a grant of the Korea Health Technology R&D
   Project (HI14C1636) through the Korea Health Industry Development
   Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic
   of Korea and the Bio & Medical Technology Development Program
   (2011-0019356) of the National Research Foundation (NRF) of Korea funded
   by the Ministry of Science, ICT & Future Planning, Republic of Korea. We
   thank to Dr. Grigori N. Enikolopov generated and provided Nes-GFP mice.
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NR 58
TC 34
Z9 40
U1 1
U2 6
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1066-5099
EI 1549-4918
J9 STEM CELLS
JI Stem Cells
PD AUG
PY 2016
VL 34
IS 8
BP 2145
EP 2156
DI 10.1002/stem.2383
PG 12
WC Cell & Tissue Engineering; Biotechnology & Applied Microbiology;
   Oncology; Cell Biology; Hematology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Biotechnology & Applied Microbiology; Oncology; Hematology
GA DS4RD
UT WOS:000380767600013
PM 27090492
OA Bronze
DA 2025-06-11
ER

PT J
AU Lushchak, OV
   Gospodaryov, DV
   Rovenko, BM
   Yurkevych, IS
   Perkhulyn, NV
   Lushchak, VI
AF Lushchak, Oleh V.
   Gospodaryov, Dmytro V.
   Rovenko, Bohdana M.
   Yurkevych, Ihor S.
   Perkhulyn, Natalia V.
   Lushchak, Volodymyr I.
TI Specific Dietary Carbohydrates Differentially Influence the Life Span
   and Fecundity of Drosophila melanogaster
SO JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL
   SCIENCES
LA English
DT Article
DE Carbohydrate diet; Sucrose; Drosophila melanogaster; Life span;
   Fecundity
ID METABOLIC SYNDROME; FRUIT-FLY; FRUCTOSE; RESTRICTION; GLUCOSE; FOOD;
   MITOCHONDRIA; EXPRESSION; COMMENSAL; CRICKETS
AB The fruit fly, Drosophila melanogaster is a broadly used model for gerontological research. Many studies are dedicated to understanding nutritional effects on ageing; however, the influence of dietary carbohydrate type and dosage is still poorly understood. We show that among three carbohydrates tested, fructose, glucose, and sucrose, the latter decreased life span by 13%-27%, being present in concentrations of 2%-20% in the diet. Life-span shortening by sucrose was accompanied by an increase in age-independent mortality. Sucrose also dramatically decreased the fecundity of the flies. The differences in life span and fecundity were determined to be unrelated to differential carbohydrate ingestion. The highest mitochondrial protein density was observed in flies fed sucrose-containing diet. However, this parameter was not affected by carbohydrate amount in the diet. Fly sensitivity to oxidative stress, induced by menadione, was increased in aged flies and was slightly affected by type and concentration of carbohydrate. In general, it has been demonstrated that sucrose, commonly used in recipes of Drosophila laboratory food, may shorten life span and lower egg-laying capability on the diets with very low protein content.
C1 [Lushchak, Oleh V.; Gospodaryov, Dmytro V.; Rovenko, Bohdana M.; Yurkevych, Ihor S.; Perkhulyn, Natalia V.; Lushchak, Volodymyr I.] Vassyl Stefanyk Precarpathian Natl Univ, Dept Biochem & Biotechnol, UA-76025 Ivano Frankivsk, Ukraine.
   [Lushchak, Oleh V.] Stockholm Univ, Dept Zool, Stockholm, Sweden.
C3 Ministry of Education & Science of Ukraine; Vasyl Stefanyk Precarpathian
   National University; Stockholm University
RP Lushchak, OV (corresponding author), Vassyl Stefanyk Precarpathian Natl Univ, Dept Biochem & Biotechnol, UA-76025 Ivano Frankivsk, Ukraine.
EM olehl@pu.if.ua
RI Yurkevych, Ihor/HJZ-2634-2023; Lushchak, Volodymyr/AAV-4256-2021;
   Lushchak, Oleh/ABE-4061-2020; ROVENKO, Bohdana/AAA-3424-2021;
   Gospodaryov, Dmytro/T-4287-2019
OI Lushchak, Volodymyr/0000-0001-5602-3330; Gospodaryov,
   Dmytro/0000-0001-8387-339X; Yurkevych, Ihor/0000-0003-3071-0014;
   Rovenko, Bohdana/0000-0002-2512-7206
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NR 49
TC 59
Z9 66
U1 3
U2 35
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1079-5006
EI 1758-535X
J9 J GERONTOL A-BIOL
JI J. Gerontol. Ser. A-Biol. Sci. Med. Sci.
PD JAN
PY 2014
VL 69
IS 1
BP 3
EP 12
DI 10.1093/gerona/glt077
PG 10
WC Geriatrics & Gerontology; Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA AD6PY
UT WOS:000333384500002
PM 23723431
OA Bronze
DA 2025-06-11
ER

PT J
AU Castellano, JM
   Guinda, A
   Delgado, T
   Rada, M
   Cayuela, JA
AF Castellano, Jose M.
   Guinda, Angeles
   Delgado, Teresa
   Rada, Mirela
   Cayuela, Jose A.
TI Biochemical Basis of the Antidiabetic Activity of Oleanolic Acid and
   Related Pentacyclic Triterpenes
SO DIABETES
LA English
DT Article
ID INDUCED DIABETIC-RATS; TYROSINE-PHOSPHATASE 1B; URSOLIC ACID;
   GLYCOGEN-PHOSPHORYLASE; ALPHA-GLUCOSIDASE; SYNTHETIC DERIVATIVES;
   INHIBITORY-ACTIVITY; INSULIN-SECRETION; OXIDATIVE STRESS; BLOOD-GLUCOSE
AB Oleanolic acid (OA), a natural component of many plant food and medicinal herbs, is endowed with a wide range of pharmacological properties whose therapeutic potential has only partly been exploited until now. Throughout complex and multifactorial mechanisms, OA exerts beneficial effects against diabetes and metabolic syndrome. It improves insulin response, preserves functionality and survival of beta-cells, and protects against diabetes complications. OA may directly modulate enzymes connected to insulin biosynthesis, secretion, and signaling. However, its major contributions appear to be derived from the interaction with important transduction pathways, and many of its effects are consistently related to activation of the transcription factor Nrf2. Doing that, OA induces the expression of antioxidant enzymes and phase II response genes, blocks NF-kappa B, and represses the polyol pathway, AGEs production, and hyperlipidemia. The management of type 2 diabetes requires an integrated approach, which includes the early intervention to prevent or delay the disease progression, and the use of therapies to control glycemia and lipidemia in its late stages. In this sense, the use of functional foods or drugs containing OA is, undoubtedly, an interesting path.
C1 [Castellano, Jose M.; Guinda, Angeles; Delgado, Teresa; Rada, Mirela; Cayuela, Jose A.] CSIC, Inst Grasa, Seville, Spain.
C3 Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Instituto
   de la Grasa (IG)
RP Castellano, JM (corresponding author), CSIC, Inst Grasa, Seville, Spain.
EM jmcas@ig.csic.es
RI Castellano Orozco, Jose Maria/L-6220-2014; Cayuela, Jose
   Antonio/H-5399-2012
OI Castellano Orozco, Jose Maria/0000-0003-3051-3264; Cayuela, Jose
   Antonio/0000-0001-9026-631X; Rada, Mirela/0000-0001-6219-4267
FU Spanish Ministry of Economy and Competitiveness (Carlos III Institute of
   Health); Andalusian Ministry of Health and Social [PI10/01415,
   PI-0037/2008]
FX The Spanish Ministry of Economy and Competitiveness (Carlos III
   Institute of Health) and the Andalusian Ministry of Health and Social
   Well-being financed the research projects PI10/01415 and PI-0037/2008,
   respectively.
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NR 79
TC 185
Z9 199
U1 0
U2 64
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0012-1797
EI 1939-327X
J9 DIABETES
JI Diabetes
PD JUN
PY 2013
VL 62
IS 6
BP 1791
EP 1799
DI 10.2337/db12-1215
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 156SU
UT WOS:000319845000003
PM 23704520
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Duluc, L
   Soleti, R
   Clere, N
   Andriantsitohaina, R
   Simard, G
AF Duluc, L.
   Soleti, R.
   Clere, N.
   Andriantsitohaina, R.
   Simard, G.
TI Mitochondria As Potential Targets of Flavonoids: Focus on Adipocytes and
   Endothelial Cells
SO CURRENT MEDICINAL CHEMISTRY
LA English
DT Review
DE Adipocyte; apoptosis; endothelial cell; flavonoids; mitochondria;
   obesity; ROS
ID NITRIC-OXIDE SYNTHASE; GREEN TEA POLYPHENOL; ACTIVATED PROTEIN-KINASE;
   ESTROGEN-RECEPTOR-ALPHA; LDL-INDUCED APOPTOSIS; DIETARY FLAVONOIDS;
   ADIPOSE-TISSUE; OXIDATIVE STRESS; METABOLIC SYNDROME; AMELIORATES
   HYPERGLYCEMIA
AB Obesity is a major public health problem, resulting from an excess of energy storage and/or a default of energy expenditure leading to the increased occurrence of cardiovascular risk factors that favour the development of vascular complications. As a consequence, many studies are interested to find novel therapeutic chemical including flavonoids that appear to be promising natural compounds to treat obesity and its complications. Several in vitro studies addressed the mechanisms involved that might explain their beneficial effects, on adipocytes and endothelial cells, two cell types that play major role in obesity and its vascular complications. Besides the well-described antioxidant properties of flavonoids, at least a part of their beneficial effects on these cell types might be explained by their action on the regulation of mitochondrial function. In this review, we will therefore focus on the pathophysiological role of mitochondria in regulating endothelial and adipocyte functions. In addition, we will present some of the more promising flavonoids, important in human diet, including flavanols, flavonols, isoflavones, anthocyanins, flavanones and flavones; and their potential effects to improve endothelial or adipocyte functions via the mitochondria.
C1 [Duluc, L.; Soleti, R.; Clere, N.; Andriantsitohaina, R.; Simard, G.] INSERM, LUNAM, U1063, F-49100 Angers, France.
C3 Institut National de la Sante et de la Recherche Medicale (Inserm);
   Universite d'Angers
RP Andriantsitohaina, R (corresponding author), INSERM U1063, Inst Biol Sante IBS IRIS, Rue Capucins, F-49045 Angers, France.
EM ramaroson.andriantsitohaina@univ-angers.fr
RI ANDRIANTSITOHAINA, Ramaroson/H-5286-2018; Clere, Nicolas/K-4414-2015;
   soleti, raffaella/AAC-1678-2021
OI SOLETI, RAFFAELLA/0000-0002-0271-0490; andriantsitohaina,
   ramaroson/0000-0002-4770-3585; Clere, Nicolas/0000-0002-6008-597X
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NR 164
TC 17
Z9 23
U1 0
U2 45
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 0929-8673
EI 1875-533X
J9 CURR MED CHEM
JI Curr. Med. Chem.
PD SEP
PY 2012
VL 19
IS 26
BP 4462
EP 4474
DI 10.2174/092986712803251467
PG 13
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Pharmacology &
   Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
GA 016IP
UT WOS:000309511500007
PM 22830333
DA 2025-06-11
ER

PT J
AU Kim, KN
   Kim, KM
   Lee, DJ
   Joo, NS
AF Kim, Kyu-Nam
   Kim, Kwang-Min
   Lee, Duck-Joo
   Joo, Nam-Seok
TI Serum Gamma-Glutamyltransferase Concentration Correlates with Framingham
   Risk Score in Koreans
SO JOURNAL OF KOREAN MEDICAL SCIENCE
LA English
DT Article
DE Gamma-Glutamyltransferase; Framingham Risk Score; Oxidative Stress
ID METABOLIC SYNDROME; BLOOD-PRESSURE; HEART-DISEASE; GLUTAMYLTRANSFERASE;
   ALCOHOL; TRANSPEPTIDASE; ASSOCIATION; DETERMINANTS; HYPERTENSION;
   DRINKING
AB Gamma-glutamyltransferase (GGT) is a novel coronary artery disease (CAD) risk factor, but its use as an independent factor for CAD risk prediction remains unclear in Asian population. This study examined the association between serum GGT concentration and Framingham risk score (FRS) in the Korean population. This cross-sectional study was performed on 30,710 Koreans. Besides FRS, body mass index, fasting blood glucose, liver enzymes, lipid profile, uric acid and high sensitive C-reactive protein data were used. The study subjects were grouped into quartiles according to the levels of GGT. Analyses relating GGT to FRS >= 20% utilized multiple confounders adjusted logistic regression. Positive correlations were established between log-transformed GGT concentration and FRS (r = 0.38; P < 0.001). Increasing the quartile of serum GGT concentration was significantly associated with linear increasing trends in FRS (P-trend < 0.001). Compared to the lowest baseline GGT category, age-gender adjusted odd ratios for FRS >= 20% were significantly increased from the lowest to highest GGT quartiles; these results remained significantly after adjustments for multiple confounders. Increased GGT concentration is associated with the increase in FRS. Serum GGT may be helpful to predict the future risk of CAD.
C1 [Kim, Kyu-Nam; Kim, Kwang-Min; Lee, Duck-Joo; Joo, Nam-Seok] Ajou Univ, Sch Med, Dept Family Practice & Community Hlth, Suwon 443721, South Korea.
C3 Ajou University
RP Joo, NS (corresponding author), Ajou Univ, Sch Med, Dept Family Practice & Community Hlth, 164 Worldcup Ro, Suwon 443721, South Korea.
EM jchcmc@hanmail.net
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NR 30
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Z9 12
U1 0
U2 2
PU KOREAN ACAD MEDICAL SCIENCES
PI SEOUL
PA 302 75 DONG DU ICHON, DONG YONGSAN KU, SEOUL 140 031, SOUTH KOREA
SN 1011-8934
EI 1598-6357
J9 J KOREAN MED SCI
JI J. Korean Med. Sci.
PD OCT
PY 2011
VL 26
IS 10
BP 1305
EP 1309
DI 10.3346/jkms.2011.26.10.1305
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 838OB
UT WOS:000296301000009
PM 22022182
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Buchynskyi, M
   Kamyshna, I
   Halabitska, I
   Petakh, P
   Kunduzova, O
   Oksenych, V
   Kamyshnyi, O
AF Buchynskyi, Mykhailo
   Kamyshna, Iryna
   Halabitska, Iryna
   Petakh, Pavlo
   Kunduzova, Oksana
   Oksenych, Valentyn
   Kamyshnyi, Oleksandr
TI Unlocking the gut-liver axis: microbial contributions to the
   pathogenesis of metabolic-associated fatty liver disease
SO FRONTIERS IN MICROBIOLOGY
LA English
DT Review
DE MAFLD; microbiota; FXR; TGR5; metabolism
ID BILE-ACID METABOLISM; NONALCOHOLIC STEATOHEPATITIS; INSULIN-RESISTANCE;
   INTESTINAL VIROME; KUPFFER CELLS; HEPATIC INFLAMMATION; NLRP3
   INFLAMMASOME; OBETICHOLIC ACID; RECEPTOR FXR; HOST
AB Metabolic dysfunction-associated fatty liver disease (MAFLD) is a complex metabolic disorder characterized by hepatic lipid accumulation and subsequent inflammation. This condition is closely linked to metabolic syndrome and obesity, with its prevalence rising due to sedentary lifestyles and high-calorie diets. The pathogenesis of MAFLD involves multiple factors, including insulin resistance, lipotoxicity, oxidative stress, and inflammatory responses. The gut microbiota plays a crucial role in MAFLD development, with dysbiosis contributing to liver inflammation through various mechanisms, such as enhanced intestinal permeability and the translocation of bacterial products like lipopolysaccharide (LPS). Microbial metabolites, including short-chain fatty acids (SCFAs) and bile acids, influence hepatic function and immune responses, with potential implications for disease progression. Specific gut microbiome signatures have been identified in MAFLD patients, offering potential diagnostic and therapeutic targets. Moreover, gut-derived toxins, such as endotoxins, lipopolysaccharides, trimethylamine-N-oxide and bacterial metabolites, significantly influence liver damage and inflammation, highlighting the complex interplay between the gut microbiome and hepatic health. This review comprehensively examines the complex interplay between the gut microbiota and MAFLD, focusing on underlying pathogenic mechanisms, potential biomarkers, and emerging microbiome-targeted therapeutic strategies for disease management.
C1 [Buchynskyi, Mykhailo; Kamyshnyi, Oleksandr] I Horbachevsky Ternopil Natl Med Univ, Dept Microbiol Virol & Immunol, Ternopol, Ukraine.
   [Kamyshna, Iryna] I Horbachevsky Ternopil Natl Med Univ, Dept Med Rehabil, Ternopol, Ukraine.
   [Halabitska, Iryna] I Horbachevsky Ternopil Natl Med Univ, Dept Therapy & Family Med, Ternopol, Ukraine.
   [Petakh, Pavlo] Uzhgorod Natl Univ, Dept Biochem & Pharmacol, Uzhgorod, Ukraine.
   [Kunduzova, Oksana] Toulouse III Univ, Inst Metab & Cardiovasc Dis I2MC, Natl Inst Hlth & Med Res, INSERM 1297, Toulouse, France.
   [Oksenych, Valentyn] Univ Bergen, Dept Clin Sci, Bergen, Norway.
C3 I. Horbachevsky Ternopil State Medical University; I. Horbachevsky
   Ternopil State Medical University; I. Horbachevsky Ternopil State
   Medical University; Ministry of Education & Science of Ukraine; Uzhgorod
   National University; Institut National de la Sante et de la Recherche
   Medicale (Inserm); Universite de Toulouse; Universite Toulouse III -
   Paul Sabatier; University of Bergen
RP Buchynskyi, M; Kamyshnyi, O (corresponding author), I Horbachevsky Ternopil Natl Med Univ, Dept Microbiol Virol & Immunol, Ternopol, Ukraine.; Oksenych, V (corresponding author), Univ Bergen, Dept Clin Sci, Bergen, Norway.
EM buchynskyi_mv@tdmu.edu.ua; valentyn.oksenych@uib.no;
   alexkamyshnyi@gmail.com
RI Oksenych, Valentyn/J-6216-2019; Kamyshnyi, Oleksandr/NES-8632-2025;
   Halabitska, Iryna/R-5739-2017; Buchynskyi, Mykhailo/GYU-1461-2022;
   PAVLO, PETAKH/IUP-8446-2023
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NR 225
TC 0
Z9 0
U1 3
U2 3
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1664-302X
J9 FRONT MICROBIOL
JI Front. Microbiol.
PD APR 25
PY 2025
VL 16
AR 1577724
DI 10.3389/fmicb.2025.1577724
PG 21
WC Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Microbiology
GA 2JO4B
UT WOS:001484182400001
PM 40351307
DA 2025-06-11
ER

PT J
AU Wen, YL
   Weng, P
   Li, YY
   Yang, LM
   Li, CJ
   Chen, QY
   He, YN
   Zhang, WP
   Hu, H
   Yuan, ZY
   Yu, C
AF Wen, Yilin
   Weng, Ping
   Li, Yueyue
   Yang, Liming
   Li, Chengju
   Chen, Qingyang
   He, Yanni
   Zhang, Wanping
   Hu, Hui
   Yuan, Zhiyi
   Yu, Chao
TI Triglyceride-Targeted Molecularly Imprinted Polymers Activate Lipophagy
   via Cargo Exchange for Nonalcoholic Fatty Liver Disease Treatment
SO ACS APPLIED POLYMER MATERIALS
LA English
DT Article
DE nonalcoholic fatty liver disease; molecularly imprintedpolymers;
   lipophagy pathway; triglyceride homeostasis; drug delivery
ID LIPID DROPLETS; AUTOPHAGY; METABOLISM; MECHANISMS; LIPOLYSIS
AB Lipid accumulation is a prominent pathologic feature of nonalcoholic fatty liver disease (NAFLD), which is due to imbalances in triglycerides metabolism. However, none of the available therapeutic strategies have been able to achieve the effective removal of triglycerides from the lesion site. Herein, MIP@QUE, a mimetic transporter with a high affinity for triglycerides, was synthesized using molecular imprinting. The physicochemical features of MIP@QUE are such that it binds to triglycerides and releases the drug in an affinity-driven reaction. In vivo and in vitro experiments showed that the metabolism of triglycerides was promoted by dual activation of the autophagy-lysosomal pathway through the size effect of the molecularly imprinted polymer (MIP) and the pharmacological action of quercetin (QUE). Moreover, MIP@QUE not only reduced triglyceride accumulation to reverse hepatic steatosis but also effectively lowered the level of oxidative stress to reduce hepatocellular damage. Targeting the key causative factors of NAFLD, MIP@QUE offers an effective therapeutic strategy to control the disease process by promoting the lysosomal transport and metabolism of triglycerides in hepatocytes; it also serves as a platform for the treatment of triglyceride-related metabolic syndrome.
C1 [Wen, Yilin; Weng, Ping; Li, Yueyue; Yang, Liming; Li, Chengju; Chen, Qingyang; He, Yanni; Zhang, Wanping; Yuan, Zhiyi; Yu, Chao] Chongqing Med Univ, Coll Pharm, Chongqing Key Res Lab Drug Metab, Chongqing 400016, Peoples R China.
   [Hu, Hui] Chongqing Med Univ, Coll Pharm, Pharmaceut & Nanomed Technol Res Ctr, Chongqing 400016, Peoples R China.
C3 Chongqing Medical University; Chongqing Medical University
RP Yuan, ZY; Yu, C (corresponding author), Chongqing Med Univ, Coll Pharm, Chongqing Key Res Lab Drug Metab, Chongqing 400016, Peoples R China.
EM yuanzhiyi-06@cqmu.edu.cn; yuchao@cqmu.edu.cn
RI Li, Chengju/GQZ-7419-2022; Wen, Yilin/AHA-2809-2022; Li,
   yueyue/GLR-6313-2022
FU Chongqing Postdoctoral Science Foundation [KJQN202100430]; Science and
   Technology Research Program of Chongqing Municipal Education Commission
   [CSTB2023NSCQ-BHX0143]; Chongqing Postdoctoral Science Foundation
FX This work was performed at Chongqing Medical University and supported by
   the Science and Technology Research Program of Chongqing Municipal
   Education Commission (KJQN202100430) and Chongqing Postdoctoral Science
   Foundation (CSTB2023NSCQ-BHX0143).
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NR 47
TC 0
Z9 0
U1 2
U2 12
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 2637-6105
J9 ACS APPL POLYM MATER
JI ACS Appl. Polym. Mater.
PD JUN 14
PY 2024
VL 6
IS 12
BP 7265
EP 7277
DI 10.1021/acsapm.4c01222
EA JUN 2024
PG 13
WC Materials Science, Multidisciplinary; Polymer Science
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Materials Science; Polymer Science
GA WZ0P7
UT WOS:001248698700001
DA 2025-06-11
ER

PT J
AU Lin, QR
   Jia, LQ
   Lei, M
   Gao, D
   Zhang, N
   Sha, L
   Liu, XH
   Liu, YD
AF Lin, Qian-Ru
   Jia, Lian-Qun
   Lei, Ming
   Gao, Di
   Zhang, Nan
   Sha, Lei
   Liu, Xu-Han
   Liu, Yu-Dan
TI Natural products as pharmacological modulators of mitochondrial
   dysfunctions for the treatment of diabetes and its complications: An
   update since 2010
SO PHARMACOLOGICAL RESEARCH
LA English
DT Article
DE Natural product; Diabetic cardiomyopathy; Diabetic neuropathy; Diabetic
   nephropathy; Mitochondrion; Diabetes
ID NF-KAPPA-B; SEED PROCYANIDIN B2; SALVIANOLIC ACID B; NLRP3 INFLAMMASOME
   ACTIVATION; OXIDATIVE STRESS; IN-VITRO; INSULIN-RESISTANCE;
   URSODEOXYCHOLIC ACID; CELL APOPTOSIS; KIDNEY DAMAGE
AB Diabetes, characterized as a well-known chronic metabolic syndrome, with its associated complications pose a substantial and escalating health and healthcare challenge on a global scale. Current strategies addressing diabetes are mainly symptomatic and there are fewer available curative pharmaceuticals for diabetic complications. Thus, there is an urgent need to identify novel pharmacological targets and agents. The impaired mitochondria have been associated with the etiology of diabetes and its complications, and the intervention of mitochondrial dysfunction represents an attractive breakthrough point for the treatments of diabetes and its complications. Natural products (NPs), with multicenter characteristics, multi-pharmacological activities and lower toxicity, have been caught attentions as the modulators of mitochondrial functions in the therapeutical filed of diabetes and its complications. This review mainly summarizes the recent progresses on the potential of 39 NPs and 2 plant-extracted mixtures to improve mitochondrial dysfunction against diabetes and its complications. It is expected that this work may be useful to accelerate the development of innovative drugs originated from NPs and improve upcoming therapeutics in diabetes and its complications.
C1 [Lin, Qian-Ru; Gao, Di; Zhang, Nan; Sha, Lei; Liu, Yu-Dan] China Med Univ, Sch Pharm, Dept Neuroendocrine Pharmacol, Shenyang 110122, Liaoning, Peoples R China.
   [Jia, Lian-Qun] Liaoning Univ Tradit Chinese Med, Key Lab, Minist Educ TCM Viscera State Theory & Applicat, Shenyang 116600, Liaoning, Peoples R China.
   [Lei, Ming] Southwest Med Univ, Inst Cardiovasc Res, Minist Educ, Key Lab Med Electrophysiol, Luzhou 646000, Peoples R China.
   [Lei, Ming] Southwest Med Univ, Inst Cardiovasc Res, Med Electrophysiol Key Lab Sichuan Prov, Luzhou 646000, Peoples R China.
   [Liu, Xu-Han] Dalian Municipal Cent Hosp, Dept Endocrinol, Dalian 116033, Liaoning, Peoples R China.
C3 China Medical University; Liaoning University of Traditional Chinese
   Medicine; Ministry of Education - China; Southwest Medical University;
   Southwest Medical University
RP Liu, YD (corresponding author), China Med Univ, Sch Pharm, Dept Neuroendocrine Pharmacol, Shenyang 110122, Liaoning, Peoples R China.; Liu, XH (corresponding author), Dalian Municipal Cent Hosp, Dept Endocrinol, Dalian 116033, Liaoning, Peoples R China.
EM xuhanliu281277@163.com; ydliu43@cmu.edu.cn
RI Lei, Ming/JAD-1050-2023
FU Scientific Research Project of Educational Department of Liaoning
   Province [JC2019033]; Natural Science Foundation of Liaoning Province of
   China [2022-MS-03]; Open fund of Key Laboratory of Ministry of Education
   for TCM Viscera-State Theory and Applications, Liaoning University of
   Traditional Chinese Medicine [zyzx2002]; Open fund of Key Laboratory of
   Medical Electrophysiology, Ministry of Education & Medical
   Electrophysiological Key Laboratory of Sichuan Province, Institute of
   Cardiovascular Research, Southwest Medical University
   [KeyME-KeyME-2020-012]
FX This work was supported by the Scientific Research Project of
   Educational Department of Liaoning Province (grant No. JC2019033) , the
   Natural Science Foundation of Liaoning Province of China (grant No.
   2022-MS-03) , the Open fund of Key Laboratory of Ministry of Education
   for TCM Viscera-State Theory and Applications, Liaoning University of
   Traditional Chinese Medicine (grant No. zyzx2002) , the Open fund of Key
   Laboratory of Medical Electrophysiology, Ministry of Education & Medical
   Electrophysiological Key Laboratory of Sichuan Province, Institute of
   Cardiovascular Research, Southwest Medical University (grant No.
   KeyME-KeyME-2020-012) .
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NR 377
TC 11
Z9 11
U1 12
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PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 1043-6618
EI 1096-1186
J9 PHARMACOL RES
JI Pharmacol. Res.
PD FEB
PY 2024
VL 200
AR 107054
DI 10.1016/j.phrs.2023.107054
EA JAN 2024
PG 37
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA GR9V9
UT WOS:001154528100001
PM 38181858
OA hybrid
DA 2025-06-11
ER

PT J
AU Sharma, V
   Patial, V
AF Sharma, Vinesh
   Patial, Vikram
TI Peroxisome proliferator-activated receptor gamma and its natural
   agonists in the treatment of kidney diseases
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Review
DE kidney diseases; natural agonists; PPAR-gamma; synthetic agonists;
   pathophysiology
ID ZHEN-WU-TANG; PPAR-GAMMA; DIABETIC-NEPHROPATHY; OXIDATIVE STRESS; IGA
   NEPHROPATHY; METABOLIC SYNDROME; INJURY; SUPPLEMENTATION; HYPERTENSION;
   INFLAMMATION
AB Kidney disease is one of the leading non-communicable diseases related to tremendous health and economic burden globally. Diabetes, hypertension, obesity and cardiovascular conditions are the major risk factors for kidney disease, followed by infections, toxicity and autoimmune causes. The peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a ligand-activated nuclear receptor that plays an essential role in kidney physiology and disease. The synthetic agonists of PPAR-gamma shows a therapeutic effect in various kidney conditions; however, the associated side effect restricts their use. Therefore, there is an increasing interest in exploring natural products with PPAR gamma-activating potential, which can be a promising solution to developing effective and safe treatment of kidney diseases. In this review, we have discussed the role of PPAR-gamma in the pathophysiology of kidney disease and the potential of natural PPAR-gamma agonists in treating various kidney diseases, including acute kidney injury, diabetic kidney disease, obesity-induced nephropathy, hypertension nephropathy and IgA nephropathy. PPAR-gamma is a potential target for the natural PPAR-gamma agonists against kidney disease; however, more studies are required in this direction.
C1 [Sharma, Vinesh; Patial, Vikram] Inst Himalayan Bioresource Technol, Dietet & Nutr Technol Div, Pharmacol & Toxicol Lab, CSIR, Palampur, HP, India.
   [Sharma, Vinesh; Patial, Vikram] Acad Sci & Innovat Res AcSIR, Ghaziabad, UP, India.
C3 Council of Scientific & Industrial Research (CSIR) - India; CSIR -
   Institute of Himalayan Bioresource Technology (IHBT); Academy of
   Scientific & Innovative Research (AcSIR)
RP Patial, V (corresponding author), Inst Himalayan Bioresource Technol, Dietet & Nutr Technol Div, Pharmacol & Toxicol Lab, CSIR, Palampur, HP, India.; Patial, V (corresponding author), Acad Sci & Innovat Res AcSIR, Ghaziabad, UP, India.
EM vikrampatial@ihbt.res.in
RI Patial, Vikram/GMW-4718-2022
FU CSIR, India [MLP0204, HCP0035]
FX The authors are thankful to the Director, CSIR-IHBT, Palampur, India,
   for his continuous support and acknowledge CSIR, India, for providing
   financial support (MLP0204 and HCP0035). The CSIR-IHBT communication
   number is 5098.
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NR 95
TC 23
Z9 25
U1 0
U2 6
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD OCT 21
PY 2022
VL 13
AR 991059
DI 10.3389/fphar.2022.991059
PG 18
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 6G3ST
UT WOS:000884676200001
PM 36339586
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Yan, X
   Zhai, YY
   Zhou, WL
   Qiao, Y
   Guan, LL
   Liu, H
   Jiang, JZ
   Peng, L
AF Yan, Xu
   Zhai, Yuanyuan
   Zhou, Wenling
   Qiao, Yuan
   Guan, Lingling
   Liu, Hao
   Jiang, Jizhi
   Peng, Liang
TI Intestinal Flora Mediates Antiobesity Effect of Rutin in High-Fat-Diet
   Mice
SO MOLECULAR NUTRITION & FOOD RESEARCH
LA English
DT Article
DE fecal microbiota transplantation; flavonoid compound; inflammation;
   intestinal flora; obesity
ID GUT MICROBIOTA; INSULIN-RESISTANCE; METABOLIC SYNDROME; INDUCED OBESITY;
   INFLAMMATION; STRESS; HEALTH; FIBER; ACIDS; SPP.
AB Scope Intestinal flora plays a critical role in the development of . Rutin is a natural flavonoid with potential prebiotic effects on regulating the intestinal flora composition that is beneficial for host health. Therefore, this study hypothesizes that rutin supplementation has beneficial effects on high-fat-diet (HFD)-induced obesity and metabolic disorder through the modulation of intestinal flora in mice. Methods and results The obesity-alleviating property of rutin using 6-week-old C57BL/6J male mice fed on HFD with or without rutin supplementation for 16 weeks is investigated. Rutin supplementation effectively reduces body-weight gain, insulin resistance, and acted favorably on the intestinal barrier, thereby reducing endotoxemia and systemic inflammation. Sequencing of 16S rRNA genes from fecal samples indicate that rutin exerted modulatory effects on HFD-induced intestinal flora disorders (e.g., rutin decreased Firmicutes abundance and increased Bacteroidetes and Verrucomicrobia abundance). Antibiotic treatment and fecal microbiota transplantation further demonstrate that the salutary effects of rutin on obesity control are strongly dependent on the intestinal flora. Conclusion Rutin can be considered as a prebiotic agent for improving intestinal flora disorders and obesity-associated metabolic perturbations in obese individuals.
C1 [Yan, Xu; Zhai, Yuanyuan; Zhou, Wenling; Jiang, Jizhi] Hebei Univ, Coll Life Sci, Baoding 071002, Hebei, Peoples R China.
   [Yan, Xu; Zhai, Yuanyuan; Zhou, Wenling; Qiao, Yuan; Guan, Lingling; Liu, Hao; Peng, Liang] China Japan Friendship Hosp, Inst Med Sci, Beijing Key Lab Immune Mediated Inflammatory Dis, 2 Yinghua East St, Beijing 100029, Peoples R China.
C3 Hebei University; China-Japan Friendship Hospital
RP Jiang, JZ (corresponding author), Hebei Univ, Coll Life Sci, Baoding 071002, Hebei, Peoples R China.; Peng, L (corresponding author), China Japan Friendship Hosp, Inst Med Sci, Beijing Key Lab Immune Mediated Inflammatory Dis, 2 Yinghua East St, Beijing 100029, Peoples R China.
EM jizhijiang909@163.com; pengliang8028@163.com
OI Peng, Liang/0000-0001-8377-0833
FU National Natural Science Foundation of China [81970713, 82170817];
   Beijing Municipal Natural Science Foundation of China [7222160];
   Capital's Funds for Health Improvement and Research [2018-2-4062]; Joint
   Project of BRC-BC (Biomedical Translational Engineering Research Center
   of BUCT-CJFH) [XK2020-10]
FX This work was supported by grants from National Natural Science
   Foundation of China (81970713 and 82170817), Beijing Municipal Natural
   Science Foundation of China (7222160), Capital's Funds for Health
   Improvement and Research (2018-2-4062), and Joint Project of BRC-BC
   (Biomedical Translational Engineering Research Center of BUCT-CJFH,
   Grant No. XK2020-10). Part of the graphical abstract was created at
   Biorender.com.
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NR 71
TC 24
Z9 26
U1 12
U2 93
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1613-4125
EI 1613-4133
J9 MOL NUTR FOOD RES
JI Mol. Nutr. Food Res.
PD JUL
PY 2022
VL 66
IS 14
AR 2100948
DI 10.1002/mnfr.202100948
EA JUN 2022
PG 16
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA 3D1EI
UT WOS:000804463300001
PM 35616308
DA 2025-06-11
ER

PT J
AU Kirkengen, AL
   Lygre, H
AF Kirkengen, Anna Luise
   Lygre, Henning
TI Exploring the relationship between childhood adversity and oral health:
   An anecdotal approach and integrative view
SO MEDICAL HYPOTHESES
LA English
DT Article
ID PERIODONTAL-DISEASE; EATING-DISORDERS; CARDIOVASCULAR-DISEASE;
   PSYCHOLOGICAL DISTRESS; METABOLIC SYNDROME; ALLOSTATIC LOAD; PRETERM
   BIRTH; SEXUAL-ABUSE; RISK-FACTORS; STRESS
AB During the past two decades, increasing recognition has been given to a relationship between oral health and systemic diseases. Associated systemic conditions include cardiovascular disease, diabetes, low birth weight and preterm births, respiratory diseases, rheumatoid arthritis, obesity, osteoporosis, and, in particular among oral conditions, periodontal disease. Low-grade inflammation is a common denominator linking these disorders. Applying an anecdotal approach and an integrative view, the medical and dental histories of two women document increasing ill health subsequent to incidences of maltreatment and sexual abuse, including oral penetration, at an early age. Comprehensive oral rehabilitation was required in both cases. These cases open for medical insight with regard to their implicit patho-physiology, when integrated with current evidence from neuroscience, endocrinology, and immunology, converging in the concepts of allostasis and allostatic load. In cases such as those presented in this paper, primary care physicians (family doctors, General Practitioners) and dentists may be the first to identify an etiological pattern. This report underlines the importance of increased and enhanced multidisciplinary research cooperation among health professionals. Our hypothesis is that childhood adversity may affect all aspects of human health, including adult oral health. (C) 2015 Elsevier Ltd. All rights reserved.
C1 [Kirkengen, Anna Luise] Norwegian Univ Sci & Technol NTNU, Dept Publ Hlth & Gen Practice, Gen Practice Res Unit, N-7491 Trondheim, Norway.
   [Kirkengen, Anna Luise] Univ Tromso, Dept Community Med, N-9001 Tromso, Norway.
   [Lygre, Henning] Univ Bergen, Dept Clin Sci, Sect Pharmacol Pharm, N-5021 Bergen, Norway.
C3 Norwegian University of Science & Technology (NTNU); UiT The Arctic
   University of Tromso; University of Bergen
RP Kirkengen, AL (corresponding author), Norwegian Univ Sci & Technol NTNU, Dept Publ Hlth & Gen Practice, Gen Practice Res Unit, POB 8905, N-7491 Trondheim, Norway.
EM anlui-k@online.no
FU General Practice Research Unit at the Norwegian University of Science
   and Technology, Trondheim, Norway; Faculty of Medicine and Dentistry at
   the University of Bergen, Norway
FX The authors have received funding for the preparation and publication of
   the present article from the General Practice Research Unit at the
   Norwegian University of Science and Technology, Trondheim, Norway and
   from the Faculty of Medicine and Dentistry at the University of Bergen,
   Norway.
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NR 91
TC 7
Z9 7
U1 0
U2 17
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0306-9877
EI 1532-2777
J9 MED HYPOTHESES
JI Med. Hypotheses
PD AUG
PY 2015
VL 85
IS 2
BP 134
EP 140
DI 10.1016/j.mehy.2015.04.020
PG 7
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA CN5KQ
UT WOS:000358468600007
PM 25978926
DA 2025-06-11
ER

PT J
AU Guler, I
   Himmetoglu, O
   Turp, A
   Erdem, A
   Erdem, M
   Onan, MA
   Taskiran, C
   Taslipinar, MY
   Guner, H
AF Guler, Ismail
   Himmetoglu, Ozdemir
   Turp, Ahmet
   Erdem, Ahmet
   Erdem, Mehmet
   Onan, M. Anil
   Taskiran, Cagatay
   Taslipinar, Mine Yavuz
   Guner, Haldun
TI Zinc and Homocysteine Levels in Polycystic Ovarian Syndrome Patients
   with Insulin Resistance
SO BIOLOGICAL TRACE ELEMENT RESEARCH
LA English
DT Article
DE Zinc; PCOS; Insulin resistance; Hyperinsulinism; Homocysteine; Metabolic
   syndrome
ID OXIDATIVE STRESS; NONOBESE WOMEN; BODY-WEIGHT; ACTIVATION; RISK;
   DYSFUNCTION; DEFICIENCY; METABOLISM; MECHANISMS; CONTRIBUTE
AB In this study, our objective was to evaluating the value of serum zinc levels as an etiologic and prognostic marker in patients with polycystic ovarian syndrome. We conducted a prospective study, including 53 women with polycystic ovarian syndrome and 33 healthy controls. We compared serum zinc levels, as well as clinical and metabolic features, of the cases. We also compared serum zinc levels between patients with polycystic ovarian syndrome with insulin resistance. Mean zinc levels were found to be significantly lower in patients with polycystic ovarian syndrome than healthy controls. Multiple logistic regression analysis of significant metabolic variables between polycystic ovarian syndrome and control groups (serum zinc level, body mass index, the ratio of triglyceride/high-density lipoprotein cholesterol, and homocysteine) revealed that zinc level was the most significant variable to predict polycystic ovarian syndrome. Mean serum zinc levels tended to be lower in patients with polycystic ovarian syndrome with impaired glucose tolerance than patients with normal glucose tolerance, but the difference was not statistically significant. In conclusion, zinc deficiency may play a role in the pathogenesis of polycystic ovarian syndrome and may be related with its long-term metabolic complications.
C1 [Guler, Ismail; Himmetoglu, Ozdemir; Turp, Ahmet; Erdem, Ahmet; Erdem, Mehmet; Onan, M. Anil; Taskiran, Cagatay; Guner, Haldun] Gazi Univ, Fac Med, Dept Obstet & Gynecol, TR-06500 Ankara, Turkey.
   [Taslipinar, Mine Yavuz] Gazi Univ, Fac Med, Dept Biochem, TR-06500 Ankara, Turkey.
C3 Gazi University; Gazi University
RP Guler, I (corresponding author), Gazi Univ, Fac Med, Dept Obstet & Gynecol, TR-06500 Ankara, Turkey.
EM driguler@yahoo.com
RI Erdem, Mehmet/HMV-5716-2023; erdem, ahmet/JFS-6453-2023; Guler,
   Ismail/HCH-1809-2022
OI Guler, Ismail/0000-0002-8098-2483; Taskiran,
   Cagatay/0000-0002-0936-552X; ERDEM, AHMET/0000-0001-9944-6894
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NR 45
TC 42
Z9 44
U1 2
U2 16
PU HUMANA PRESS INC
PI TOTOWA
PA 999 RIVERVIEW DRIVE SUITE 208, TOTOWA, NJ 07512 USA
SN 0163-4984
EI 1559-0720
J9 BIOL TRACE ELEM RES
JI Biol. Trace Elem. Res.
PD JUN
PY 2014
VL 158
IS 3
BP 297
EP 304
DI 10.1007/s12011-014-9941-7
PG 8
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA AG9WX
UT WOS:000335771800005
PM 24664271
DA 2025-06-11
ER

PT J
AU Millon, A
   Canet-Soulas, E
   Boussel, L
   Fayad, Z
   Douek, P
AF Millon, Antoine
   Canet-Soulas, Emmanuelle
   Boussel, Loic
   Fayad, Zahi
   Douek, Philippe
TI Animal models of atherosclerosis and magnetic resonance imaging for
   monitoring plaque progression
SO VASCULAR
LA English
DT Review
DE atherosclerosis; animal models; MRI
ID APOLIPOPROTEIN-E-DEFICIENT; ENDOTHELIAL SHEAR-STRESS;
   CORONARY-ARTERY-DISEASE; IN-VIVO; CAROTID-ARTERY; METABOLIC SYNDROME;
   ACCELERATED ATHEROSCLEROSIS; TRANSGENIC RABBITS; BALLOON INJURY; MOUSE
   MODEL
AB Atherosclerosis, the main cause of heart attack and stroke, is the leading cause of death in most modern countries. Preventing clinical events depends on a better understanding of the mechanism of atherosclerotic plaque destabilization. Our knowledge on the characteristics of vulnerable plaques in humans has grown past decades. Histological studies have provided a precise definition of high-risk lesions and novel imaging methods for human atherosclerotic plaque characterization have made significant progress. However the pathological mechanisms leading from stable lesions to the formation of vulnerable plaques remain uncertain and the related clinical events are unpredictable. An animal model mimicking human plaque destablization is required as well as an in vivo imaging method to assess and monitor atherosclerosis progression. Magnetic resonance imaging (MRI) is increasingly used for in vivo assessment of atherosclerotic plaques in the human carotids. MRI provides well-characterized morphological and functional features of human atherosclerotic plaque which can be also assessed in animal models. This review summarizes the most common species used as animal models for experimental atherosclerosis, the techniques to induce atherosclerosis and to obtain vulnerable plaques, together with the role of MRI for monitoring atherosclerotic plaques in animals.
C1 [Millon, Antoine] Univ Hosp Lyon, Dept Vasc Surg, F-69000 Lyon, France.
   [Millon, Antoine; Boussel, Loic; Douek, Philippe] Lyon Univ, CNRS, INSERM, CREATIS,UMR 5515,U630, F-69000 Lyon, France.
   [Canet-Soulas, Emmanuelle] Univ Lyon 1, INSERM, U1060, CarMeN Lab, F-69000 Lyon, France.
   [Canet-Soulas, Emmanuelle] Univ Lyon 1, CENS, F-69000 Lyon, France.
   [Boussel, Loic; Douek, Philippe] Hop Cardiovasc & Pneumol, Dept Radiol, F-69000 Lyon, France.
   [Fayad, Zahi] Mt Sinai Sch Med, Translat & Mol Imaging Inst, New York, NY 10029 USA.
C3 CHU Lyon; Institut National de la Sante et de la Recherche Medicale
   (Inserm); Centre National de la Recherche Scientifique (CNRS); Institut
   National des Sciences Appliquees de Lyon - INSA Lyon; Institut National
   de la Sante et de la Recherche Medicale (Inserm); Universite Claude
   Bernard Lyon 1; Universite Claude Bernard Lyon 1; CHU Lyon; Icahn School
   of Medicine at Mount Sinai
RP Millon, A (corresponding author), Hop Edouard Herriot, Dept Vasc Surg, Pl Arsonval, F-69003 Lyon, France.
EM antoinemillon@hotmail.com
RI Boussel, Loic/H-7184-2014; Canet Soulas, Emmanuelle/AAZ-7523-2021;
   douek, philippe/C-3993-2019; Fayad, Zahi/Z-3272-2019
OI Carmen, Team3/0000-0002-3614-0924; Carmen, Team1/0000-0003-4234-1746;
   Lab, Carmen/0000-0002-5935-3236
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NR 172
TC 22
Z9 24
U1 0
U2 33
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1708-5381
EI 1708-539X
J9 VASCULAR
JI Vascular
PD JUN
PY 2014
VL 22
IS 3
BP 221
EP 237
DI 10.1177/1708538113478758
PG 17
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA AI8NY
UT WOS:000337177100015
PM 24907292
DA 2025-06-11
ER

PT J
AU Alisi, A
   Locatelli, M
   Nobili, V
AF Alisi, Anna
   Locatelli, Mattia
   Nobili, Valerio
TI Nonalcoholic fatty liver disease in children
SO CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE
LA English
DT Article
DE children; fibrosis; management; nonalcoholic fatty liver disease;
   steatohepatitis
ID LIFE-STYLE INTERVENTION; OBESE CHILDREN; METABOLIC SYNDROME;
   INSULIN-RESISTANCE; STEATOHEPATITIS; ADOLESCENTS; DIAGNOSIS; FIBROSIS;
   PATHOGENESIS; PREVALENCE
AB Purpose of review
   The intent of this review is to provide a concise overview of all recent acquisitions in terms of therapies and early noninvasive diagnostic approaches for nonalcoholic fatty liver disease (NAFLD) in children.
   Recent findings
   NAFLD is increasingly being diagnosed in children. If undiscovered and if certain risks are present (i.e. obesity), nonalcoholic steatohepatitis, the most severe form of NAFLD, may silently progress to cirrhosis, hepatocarcinoma and liver-related death in adulthood. Current therapies include approaches for reducing the incidence of risk factors (i.e. weight reduction), drugs targeting the major molecular mechanisms thought essential in the pathogenesis of the disease (insulin resistance and oxidative stress) or both, but other novel treatments are under investigation.
   Summary
   Although weight reduction, achieved through a combination of diet and exercise, makes it possible to modify the natural course of simple steatosis, the addition of adequate drugs might also provide a therapeutic action on nonalcoholic steatohepatitis. Moreover, preventive strategies and the design and translation into clinical practice of indices that integrate noninvasive diagnostic tools and serum biomarkers might be a winning approach for improving management of paediatric NAFLD/nonalcoholic steatohepatitis in the coming years.
C1 [Alisi, Anna; Nobili, Valerio] Pediat Hosp IRCCS Bambino Gesu, Unit Metab & Autoimmune Liver Dis, I-00165 Rome, Italy.
   [Locatelli, Mattia] Pediat Hosp IRCCS Bambino Gesu, Sci Directorate, I-00165 Rome, Italy.
C3 IRCCS Bambino Gesu; IRCCS Bambino Gesu
RP Nobili, V (corresponding author), Pediat Hosp IRCCS Bambino Gesu, Liver Unit, Sci Directorate, P le S Onofrio 4, I-00165 Rome, Italy.
EM nobili66@yahoo.it
RI Alisi, Anna/A-6469-2010; Locatelli, Mattia/AAA-6241-2020; Nobili,
   Valerio/K-8670-2018
OI Alisi, Anna/0000-0001-7241-6329; nobili, valerio/0000-0002-4570-3979
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NR 54
TC 32
Z9 34
U1 0
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1363-1950
EI 1473-6519
J9 CURR OPIN CLIN NUTR
JI Curr. Opin. Clin. Nutr. Metab. Care
PD JUL
PY 2010
VL 13
IS 4
BP 397
EP 402
DI 10.1097/MCO.0b013e32833aae84
PG 6
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 621LA
UT WOS:000279579100008
PM 20531177
DA 2025-06-11
ER

PT J
AU Neyrinck, AM
   Sánchez, CR
   Rodriguez, J
   Cani, PD
   Bindels, LB
   Delzenne, NM
AF Neyrinck, Audrey M.
   Sanchez, Candido Robles
   Rodriguez, Julie
   Cani, Patrice D.
   Bindels, Laure B.
   Delzenne, Nathalie M.
TI Prebiotic Effect of Berberine and Curcumin Is Associated with the
   Improvement of Obesity in Mice
SO NUTRIENTS
LA English
DT Article
DE berberine; curcumin; prebiotic; gut barrier; liver injury; obesity;
   inflammation
ID GUT MICROBIOTA; ANTIMICROBIAL DEFENSE; METABOLIC SYNDROME; INFLAMMATION;
   AKKERMANSIA; DYSFUNCTION; MODULATION; PROTECTS
AB Berberine and curcumin, used as food additives or food supplements, possess interesting anti-inflammatory and antioxidant properties. We tested the potential protective effect of both phytochemicals in genetically obese mice and we determined whether these effects can be related to the modulation of gut functions and microbiota. Ob/ob mice were fed a standard diet supplemented with or without 0.1% berberine and/or 0.3% curcumin for 4 weeks. By using targeted qPCR, we found that cecal content of Bifidobacterium spp. and Akkermansia spp. increased mainly upon berberine supplementation. Genes involved in innate immunity (Pla2g2a), mucus production (Muc2) and satietogenic peptide production (Gcg and Pyy) were upregulated in the colon of mice treated with both phytochemicals. Berberine supplementation alone reduced food intake, body weight gain, hypertriglyceridemia and hepatic inflammatory and oxidative stress markers, thus lessening hepatic injury. The increase in Bifidobacterium spp. and Akkermansia spp. was correlated with the improvement of gut barrier function and with the improvement of hepatic inflammatory and oxidative stresses in obese mice. These data support the fact that non-carbohydrate phytochemicals may modulate the gut microbiota in obesity and related gut and hepatic alterations.
C1 [Neyrinck, Audrey M.; Sanchez, Candido Robles; Rodriguez, Julie; Cani, Patrice D.; Bindels, Laure B.; Delzenne, Nathalie M.] Catholic Univ Louvain, UCLouvain, Metab & Nutr Res Grp, Louvain Drug Res Inst, B-1200 Brussels, Belgium.
   [Cani, Patrice D.] UCLouvain, Louvain Drug Res Inst, Walloon Excellence Life Sci & BIOtechnol WELBIO, B-1200 Brussels, Belgium.
C3 Universite Catholique Louvain; WELBIO; Universite Catholique Louvain
RP Delzenne, NM (corresponding author), Catholic Univ Louvain, UCLouvain, Metab & Nutr Res Grp, Louvain Drug Res Inst, B-1200 Brussels, Belgium.
EM audrey.neyrinck@uclouvain.be; candido.robles@uclouvain.be;
   j.rodriguez@uclouvain.be; patrice.cani@uclouvain.be;
   laure.bindels@uclouvain.be; nathalie.delzenne@uclouvain.be
RI Delzenne, Nathalie/AAC-4628-2019; Bindels, Laure/T-7846-2019; Rodriguez,
   Julie/AAM-7813-2020; Neyrinck, Audrey/AAE-7929-2019; Cani, Patrice
   D./M-8055-2016
OI Delzenne, Nathalie/0000-0003-2115-6082; Cani, Patrice
   D./0000-0003-2040-2448; Neyrinck, Audrey/0000-0002-9435-3338; Rodriguez,
   Julie/0000-0002-8271-3893
FU Fundacion Alfonso Martin Escudero; Service Public de Wallonie (SPW-EER)
   [1610365, 8225]; Fonds de la Recherche Scientifique (FRS-FNRS)
   [PINT-MULTI R.8013.19, PDR T.0068.19]; Federation Wallonie-Bruxelles
   [ARC18-23/092]; Fonds de la Recherche Scientifique (FNRS) [30770923,
   FRFS-WELBIO: WELBIOCR-2019C-02R, FNRS T.0030.21]
FX We thank Bouazza Es Saadi and Isabelle Blave for their excellent
   technical assistance. Candido Robles Sanchez (CRS) is a beneficiary of a
   postdoctoral fellowship program from Fundacion Alfonso Martin Escudero.
   NMD is a recipient of grants from the Service Public de Wallonie
   (SPW-EER, convention 1610365 and convention 8225), from the Fonds de la
   Recherche Scientifique (FRS-FNRS, convention PINT-MULTI R.8013.19
   (NEURON, call 2019) and convention PDR T.0068.19) and from the
   Federation Wallonie-Bruxelles (Action de Recherche Concertee
   ARC18-23/092). PDC is supported by the Fonds de la Recherche
   Scientifique (FNRS, FRFS-WELBIO: WELBIOCR-2019C-02R, FNRS T.0030.21 and
   EOS program no. 30770923).
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NR 58
TC 28
Z9 29
U1 0
U2 25
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD MAY
PY 2021
VL 13
IS 5
AR 1436
DI 10.3390/nu13051436
PG 13
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA ST4TR
UT WOS:000662438400001
PM 33923174
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Pollard, AE
   Carling, D
AF Pollard, Alice E.
   Carling, David
TI Thermogenic adipocytes: lineage, function and therapeutic potential
SO BIOCHEMICAL JOURNAL
LA English
DT Review
ID BROWN ADIPOSE-TISSUE; HORMONE-SENSITIVE LIPASE; MITOCHONDRIAL UNCOUPLING
   PROTEIN; SKELETAL-MUSCLE THERMOGENESIS; DIET-INDUCED THERMOGENESIS;
   BEIGE FAT DEVELOPMENT; WHITE FAT; STEM-CELLS; TRANSCRIPTIONAL CONTROL;
   SARCOPLASMIC-RETICULUM
AB Metabolic inflexibility, defined as the inability to respond or adapt to metabolic demand, is now recognised as a driving factor behind many pathologies associated with obesity and the metabolic syndrome. Adipose tissue plays a pivotal role in the ability of an organism to sense, adapt to and counteract environmental changes. It provides a buffer in times of nutrient excess, a fuel reserve during starvation and the ability to resist cold-stress through non-shivering thermogenesis. Recent advances in single-cell RNA sequencing combined with lineage tracing, transcriptomic and proteomic analyses have identified novel adipocyte progenitors that give rise to specialised adipocytes with diverse functions, some of which have the potential to be exploited therapeutically. This review will highlight the common and distinct functions of well-known adipocyte populations with respect to their lineage and plasticity, as well as introducing the most recent members of the adipocyte family and their roles in whole organism energy homeostasis. Finally, this article will outline some of the more preliminary findings from large data sets generated by single-cell transcriptomics of mouse and human adipose tissue and their implications for the field, both for discovery and for therapy.
C1 [Pollard, Alice E.; Carling, David] Imperial Coll London, Hammersmith Hosp, MRC London Inst Med Sci, London W12 0NN, England.
   [Pollard, Alice E.] AstraZeneca, Biopharmaceut R&D, Discovery Sci, Struct Biophys & Fragments, Cambridge, England.
   [Carling, David] Imperial Coll London, Hammersmith Hosp, Inst Clin Sci, London W12 0NN, England.
C3 Imperial College London; AstraZeneca; Imperial College London
RP Carling, D (corresponding author), Imperial Coll London, Hammersmith Hosp, MRC London Inst Med Sci, London W12 0NN, England.; Carling, D (corresponding author), Imperial Coll London, Hammersmith Hosp, Inst Clin Sci, London W12 0NN, England.
EM david.carling@lms.mrc.ac.uk
RI ; Carling, David/F-1943-2014
OI Pollard, Alice/0000-0001-5049-3761; Carling, David/0000-0002-2316-1830
FU Medical Research Council [MC-A654-5QB10]; AstraZeneca; MRC
   [MC_U120027537] Funding Source: UKRI
FX Work in the authors' laboratory was funded by the Medical Research
   Council [MC-A654-5QB10] and through a post-doctoral fellowship from
   AstraZeneca (A.E.P.).
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NR 273
TC 15
Z9 17
U1 0
U2 8
PU PORTLAND PRESS LTD
PI LONDON
PA 1ST FLR, 10 QUEEN STREET PLACE, LONDON, ENGLAND
SN 0264-6021
EI 1470-8728
J9 BIOCHEM J
JI Biochem. J.
PD JUN
PY 2020
VL 477
IS 11
BP 2071
EP 2093
DI 10.1042/BCJ20200298
PG 23
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA MG8FH
UT WOS:000546265800004
PM 32539124
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Kim, CY
   Paek, YJ
   Seo, HG
   Cheong, YS
   Lee, CM
   Park, SM
   Park, D
   Lee, K
AF Kim, Choon-Young
   Paek, Yu-Jin
   Seo, Hong Gwan
   Cheong, Yoo Seock
   Lee, Cheol Min
   Park, Sang Min
   Park, Da Won
   Lee, Kiheon
TI Dual use of electronic and conventional cigarettes is associated with
   higher cardiovascular risk factors in Korean men
SO SCIENTIFIC REPORTS
LA English
DT Article
AB Most smokers who use electronic cigarettes (e-cigarettes) to stop smoking simultaneously use conventional cigarettes (dual users). We aimed to compare the prevalence of cardiovascular risk factors among dual users, cigarette-only smokers, and never smokers in Korean men. We used data acquired from Korean National Health and Nutrition Examination Survey (2013-2017) pertaining to 7,505 male participants aged 19 years or older. About 85% of e-cigarette users were dual users. Dual users had greater nicotine dependence and higher urinary cotinine levels than cigarette-only smokers. Dual users had more psychosocial and behavioural risk factors, including perceived high stress, depressive mood, high daily intake of energy, and obesity, than never smokers and cigarette-only smokers. The prevalence of metabolic syndrome (MetS) was higher among dual users, and their multivariate-adjusted prevalence odds ratio for MetS was 2.79 (P<0.001) compared with never smokers and 1.57 (P=0.038) compared with cigarette-only smokers. Given that most e-cigarette users are dual users and dual users are more vulnerable to cardiovascular risk factors than cigarette-only smokers and never smokers, more active treatment for smoking cessation and intensive lifestyle interventions for dual users should be considered with priority.
C1 [Kim, Choon-Young; Lee, Kiheon] Seoul Natl Univ, Dept Family Med, Bundang Hosp, Seongnam, South Korea.
   [Paek, Yu-Jin] Hallym Univ, Hlth Promot Ctr, Dept Family Med, Sacred Heart Hosp, Anyang, South Korea.
   [Seo, Hong Gwan] Natl Canc Ctr, Ctr Canc Prevent & Detect, Goyang, South Korea.
   [Seo, Hong Gwan] Natl Canc Ctr, Dept Canc Control & Populat Hlth, Grad Sch Canc Sci & Policy, Goyang, South Korea.
   [Cheong, Yoo Seock] Dankook Univ, Dept Family Med, Coll Med, Cheonan, South Korea.
   [Lee, Cheol Min] Seoul Natl Univ Hosp, Healthcare Syst Gangnam Ctr, Dept Family Med, Seoul, South Korea.
   [Park, Sang Min; Park, Da Won] Seoul Natl Univ Hosp, Dept Family Med, Seoul, South Korea.
   [Park, Sang Min; Lee, Kiheon] Seoul Natl Univ, Dept Family Med, Coll Med, Seoul, South Korea.
   [Park, Sang Min] Seoul Natl Univ, Dept Biomed Sci, Grad Sch, Seoul, South Korea.
C3 Seoul National University (SNU); Hallym University; National Cancer
   Center - Korea (NCC); National Cancer Center - Korea (NCC); Dankook
   University; Seoul National University (SNU); Seoul National University
   Hospital; Seoul National University (SNU); Seoul National University
   Hospital; Seoul National University (SNU); Seoul National University
   (SNU)
RP Lee, K (corresponding author), Seoul Natl Univ, Dept Family Med, Bundang Hosp, Seongnam, South Korea.; Lee, K (corresponding author), Seoul Natl Univ, Dept Family Med, Coll Med, Seoul, South Korea.
EM keyhone2@snu.ac.kr
RI Park, Sang/V-9194-2019; Kim, Choon/A-6698-2016
OI Lee, Cheolmin/0000-0001-8652-4355
FU Korea Health Promotion Institute [2010700-1] Funding Source: Korea
   Institute of Science & Technology Information (KISTI), National Science
   & Technology Information Service (NTIS)
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NR 33
TC 77
Z9 82
U1 0
U2 4
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD MAR 27
PY 2020
VL 10
IS 1
AR 5612
DI 10.1038/s41598-020-62545-3
PG 10
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Science & Technology - Other Topics
GA NB3IF
UT WOS:000560407700006
PM 32221375
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Chen, T
   Ren, Y
   Gao, Y
   Tian, HM
AF Chen, Tao
   Ren, Yan
   Gao, Yun
   Tian, Haoming
TI Serum Gamma-Glutamyl Transferase and Ferritin Synergistically Associated
   with the Rate of Chronic Kidney Disease
SO DISEASE MARKERS
LA English
DT Article
ID ARTERY RISK DEVELOPMENT; OXIDATIVE STRESS; HYPERTENSION; PREVALENCE
AB The present study investigated the effects of GGT and SF on the risk of CKD. 1024 participants (436 men and 588 women) were divided into three groups according to GGT and SF levels: group 1 (both GGT and SF not in the fourth quartile), group 2 (only GGT or SF in the fourth quartile), and group 3 (both GGT and SF in the fourth quartile). The risks of CKD in different levels of GGT and SF and in groups 2-3 compared with group 1 were analyzed by multiple logistic regression. GGT or SF in the highest quartile was associated with increased risk of CKD. Such associations attenuated after adjustment for confounding factors. The incidences of CKD, especially albuminuria, increased across the three groups. Correspondingly, malondialdehyde (MDA) levels gradually increased from group 1 to group 3. The risks of CKD were higher in groups 2 and 3 than that in group 1. In group 3, the increased rate was independent of age, BMI, alcohol drinking, diabetes mellitus, hypertension, hypertriglyceridemia, and metabolic syndrome (odds ratios from 1.887 to 2.293, P < 0.05). In summary, this study suggested that GGT and SF synergistically influence the rate of CKD.
C1 [Chen, Tao; Ren, Yan; Gao, Yun; Tian, Haoming] Sichuan Univ, Dept Endocrinol & Metab, West China Hosp, Chengdu 610041, Peoples R China.
C3 Sichuan University
RP Tian, HM (corresponding author), Sichuan Univ, Dept Endocrinol & Metab, West China Hosp, Chengdu 610041, Peoples R China.
EM hmtian999@126.com
OI Chen, Tao/0000-0002-8371-779X
FU Chinese National Nature Science Foundation [81100572]
FX This study was supported by the Chinese National Nature Science
   Foundation (81100572).
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PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 0278-0240
EI 1875-8630
J9 DIS MARKERS
JI Dis. Markers
PY 2017
VL 2017
AR 9765259
DI 10.1155/2017/9765259
PG 7
WC Biotechnology & Applied Microbiology; Genetics & Heredity; Medicine,
   Research & Experimental; Pathology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Genetics & Heredity; Research &
   Experimental Medicine; Pathology
GA EY2CW
UT WOS:000403777000001
PM 28659657
OA Green Submitted, hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Madonna, R
   Novo, G
   Balistreri, CR
AF Madonna, Rosalinda
   Novo, Giuseppina
   Balistreri, Carmela Rita
TI Cellular and molecular basis of the imbalance between vascular damage
   and repair in ageing and age-related diseases: As biomarkers and targets
   for new treatments
SO MECHANISMS OF AGEING AND DEVELOPMENT
LA English
DT Article
DE Stem and progenitor cells; Biomarkers; Ageing; Vascular disease
ID ENDOTHELIAL PROGENITOR CELLS; HEMATOPOIETIC STEM-CELLS;
   CARDIOVASCULAR-DISEASES; DNA-DAMAGE; REPLICATION STRESS; SHORT
   TELOMERES; SELF-RENEWAL; TASK-FORCE; TRANSPLANTATION; SENESCENCE
AB Preclinical and clinical studies suggest that specific subsets of cells isolated from the peripheral blood, play an essential role in the imbalance of damage and repair during age-associated diseases, such as metabolic syndrome, diabetes, atherosclerosis, neurodegenerative diseases, osteoporosis and cancer. Endogenous regeneration of the vessel wall involves cells of the vascular wall, inflammatory cells, circulating precursors, and mature endothelial cells, which are capable to restore the endothelium in a concerted interaction. Early detection of such imbalances with specific biomarkers may reduce age associated diseases and subsequent cardiovascular events. Likewise, new strategies have the potentiality of acting selectively on these cell populations and co-temporally mediate the stimulation of the function and number of those cell populations with regenerative action on the vessel, and inhibit those able to evocate vascular damage. These strategies may be an alternative innovative way with superior and more efficacy biological effects than conventional attempts used for treating actually vascular diseases, characterizing those co-morbidities related to ageing. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
C1 [Madonna, Rosalinda] Univ G DAnnunzio, Dept Neurosci Imaging & Clin Sci, Inst Cardiol, Ctr Excellence Aging, I-66100 Chieti, Italy.
   [Novo, Giuseppina] Univ Palermo, Dept Pathobiol & Med Biotechnol, I-90134 Palermo, Italy.
   [Balistreri, Carmela Rita] Univ Palermo, Dept Internal Med & Special, Chair Cardiol, I-90127 Palermo, Italy.
C3 G d'Annunzio University of Chieti-Pescara; University of Palermo;
   University of Palermo
RP Novo, G (corresponding author), Univ Palermo, Dept Pathobiol & Med Biotechnol, I-90134 Palermo, Italy.
EM giuseppina.novo@unipa.it
RI novo, giuseppina/K-6580-2016; Balistreri, Carmela Rita/K-9495-2016
OI Madonna, Rosalinda/0000-0001-6455-2777; Balistreri, Carmela
   Rita/0000-0002-5393-1007
FU Italian Ministry of University and Scientific Research (PRIN); CARIPLO
   Foundation
FX This work was supported by grants from the Italian Ministry of
   University and Scientific Research (PRIN), and from the CARIPLO
   Foundation (all to R. Madonna).
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NR 79
TC 41
Z9 42
U1 0
U2 8
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0047-6374
J9 MECH AGEING DEV
JI Mech. Ageing Dev.
PD OCT
PY 2016
VL 159
SI SI
BP 22
EP 30
DI 10.1016/j.mad.2016.03.005
PG 9
WC Cell Biology; Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Geriatrics & Gerontology
GA EB2MI
UT WOS:000387196100004
PM 26993150
DA 2025-06-11
ER

PT J
AU Satoh, M
   Takahashi, Y
   Tabuchi, T
   Minami, Y
   Tamada, M
   Takahashi, K
   Itoh, T
   Morino, Y
   Nakamura, M
AF Satoh, Mamoru
   Takahashi, Yuji
   Tabuchi, Tsuyoshi
   Minami, Yoshitaka
   Tamada, Makiko
   Takahashi, Kan
   Itoh, Tomonori
   Morino, Yoshihiro
   Nakamura, Motoyuki
TI Cellular and molecular mechanisms of statins: an update on pleiotropic
   effects
SO CLINICAL SCIENCE
LA English
DT Review
DE atherosclerosis; endothelial progenitor cells; miRNA; SIRT-1; telomere;
   toll-like receptor 4
ID ENDOTHELIAL PROGENITOR CELLS; ACUTE CORONARY SYNDROMES; HIGH-DOSE
   ATORVASTATIN; C-REACTIVE PROTEIN; NLRP3 INFLAMMASOME ACTIVATION;
   LIPID-LOWERING THERAPY; TOLL-LIKE RECEPTORS; METABOLIC SYNDROME;
   OXIDATIVE STRESS; CHOLESTEROL REDUCTION
AB Coronary artery disease ( CAD) is the leading cause of death worldwide. The efficacy and safety of statins (3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors) in primary and secondary prevention of CAD are confirmed in several large studies. It is well known that statins have some pleiotropic, anti-atherosclerotic effects. We review the molecular mechanisms underlying the beneficial effects of statins revealed in recently published studies. Endothelial cell injury is regarded as the classic stimulus for the development of atherosclerotic lesions. In addition, the inflammatory process plays an important role in the aetiology of atherosclerosis. In particular, chronic inflammation plays a key role in coronary artery plaque instability and subsequent occlusive thrombosis. Our previous reports and others have demonstrated beneficial effects of statins on endothelial dysfunction and chronic inflammation in CAD. A better understanding of the molecular mechanism underlying the effectiveness of statins against atherosclerosis may provide a novel therapeutic agent for the treatment of coronary atherosclerosis. The present review summarizes the cellular and molecular mechanism of statins against coronary atherosclerosis.
C1 [Satoh, Mamoru] Iwate Med Univ, Inst Biomed Sci, Div Biomed Informat Anal, Morioka, Iwate, Japan.
   [Takahashi, Yuji; Takahashi, Kan; Itoh, Tomonori; Morino, Yoshihiro] Iwate Med Univ, Sch Med, Dept Internal Med, Div Cardiol, Morioka, Iwate, Japan.
   [Tabuchi, Tsuyoshi; Minami, Yoshitaka; Tamada, Makiko; Nakamura, Motoyuki] Iwate Med Univ, Sch Med, Div Cardioangiol Nephrol & Endocrinol, Morioka, Iwate, Japan.
C3 Iwate Medical University; Iwate Medical University; Iwate Medical
   University
RP Satoh, M (corresponding author), Iwate Med Univ, Inst Biomed Sci, Div Biomed Informat Anal, Morioka, Iwate, Japan.
EM satohm@iwate-med.ac.jp
OI Itoh, Tomonori/0000-0001-9277-6567
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NR 86
TC 68
Z9 76
U1 0
U2 44
PU PORTLAND PRESS LTD
PI LONDON
PA 5TH FLR, 90 HIGH HOLBORN, LONDON WC1V 6LJ, ENGLAND
SN 0143-5221
EI 1470-8736
J9 CLIN SCI
JI Clin. Sci.
PD JUL
PY 2015
VL 129
IS 2
BP 93
EP 105
DI 10.1042/CS20150027
PG 13
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA CI3NV
UT WOS:000354655400001
PM 25927679
DA 2025-06-11
ER

PT J
AU Lin, YC
   Chen, YC
   Hsieh, HI
   Chen, PC
AF Lin, Yu-Cheng
   Chen, Yen-Cheng
   Hsieh, Hui-I
   Chen, Pau-Chung
TI Risk for Work-Related Fatigue Among the Employees on Semiconductor
   Manufacturing Lines
SO ASIA-PACIFIC JOURNAL OF PUBLIC HEALTH
LA English
DT Article
DE need-for-recovery; risk assessment; rotating shift work; work-related
   fatigue
ID METABOLIC SYNDROME; RECOVERY; NEED; HEALTH; STRESS; PROGRAM; QUALITY;
   LIFE
AB To examine the potential risk factors for work-related fatigue (WRF) among workers in modern industries, the authors analyzed the records of need-for-recovery questionnaires and health checkup results for 1545 employees. Compared with regular daytime workers, and after adjusting for confounders, the workers adapting to day-and-night rotating shift work (RSW) had a 4.0-fold (95% confidence interval [CI] = 2.7-5.9) increased risk for WRF, higher than the 2.2-fold risk (95% CI = 1.5-3.3) for persistent shift workers. Based on highest education level, the male employees with university degrees had the highest adjusted odds ratio (a-OR) 2.8 (95% CI = 1.0-7.8) for complaining of WRF versus compulsory education group. For female workers, currently married/cohabiting status was inversely associated with WRF (a-OR = 0.5; 95% CI = 0.2-0.9), and child-rearing responsibility moderately increased WRF risk (a-OR = 1.9; 95% CI = 1.0-3.7). Day-and-night RSW and the adaptation, educational levels of males, and domestic factors for females contributed to WRF among semiconductor manufacturing employees.
C1 [Lin, Yu-Cheng] En Chu Kong Hosp, New Taipei, Taiwan.
   [Lin, Yu-Cheng; Hsieh, Hui-I] Fu Jen Catholic Univ, New Taipei, Taiwan.
   [Lin, Yu-Cheng; Chen, Yen-Cheng; Chen, Pau-Chung] Natl Taiwan Univ, Taipei 10764, Taiwan.
   [Lin, Yu-Cheng] Tao Yuan Gen Hosp, Taoyuan, Taiwan.
   [Chen, Yen-Cheng] Sijhih Cathay Gen Hosp, New Taipei, Taiwan.
   [Hsieh, Hui-I] Cathay Gen Hosp, Taipei, Taiwan.
C3 Fu Jen Catholic University; National Taiwan University; Cathay General
   Hospital; Cathay General Hospital
RP Chen, PC (corresponding author), Natl Taiwan Univ, Coll Publ Hlth, Inst Occupat Med & Ind Hyg, Room 733,17 Syujhou Rd, Taipei 10055, Taiwan.
EM pchen@ntu.edu.tw
RI 林, 煜程/HSI-3146-2023; Chen, Pau-Chung/H-5686-2011
OI Chen, Pau-Chung/0000-0002-6242-5974; Lin, Yu Cheng/0000-0003-4648-8745
CR Cheng TJ, 2005, IOSH RESEARCH PROGRA
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NR 30
TC 3
Z9 3
U1 1
U2 20
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1010-5395
EI 1941-2479
J9 ASIA-PAC J PUBLIC HE
JI Asia-Pac. J. Public Health
PD MAR
PY 2015
VL 27
IS 2
BP NP1805
EP NP1818
DI 10.1177/1010539513490788
PG 14
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA CF5GT
UT WOS:000352586200169
PM 23761590
DA 2025-06-11
ER

PT J
AU Michelotti, GA
   Machado, MV
   Diehl, AM
AF Michelotti, Gregory A.
   Machado, Mariana V.
   Diehl, Anna Mae
TI NAFLD, NASH and liver cancer
SO NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
LA English
DT Review
ID NF-KAPPA-B; GROWTH-FACTOR-BETA; TUMOR-SUPPRESSOR GENE;
   HEPATITIS-C-VIRUS; BODY-MASS INDEX; HEPATOCELLULAR-CARCINOMA; FATTY
   LIVER; NONALCOHOLIC STEATOHEPATITIS; S-ADENOSYLMETHIONINE;
   CLINICAL-FEATURES
AB NAFLD affects a large proportion of the US population and its incidence and prevalence are increasing to epidemic proportions around the world. As with other liver diseases that cause cirrhosis, NAFLD increases the risk of liver cancer, a disease with poor outcomes and limited therapeutic options. The incidences of hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma are also rising, and HCC is now the leading cause of obesity-related cancer deaths in middle-aged men in the USA. In this Review, we summarize the correlations between liver cancer and NAFLD-related cirrhosis, and the role of the metabolic syndrome in the development of liver cancer from diverse aetiologies, including HCV-mediated cirrhosis. Recent advances in understanding the progression of NAFLD to HCC from preclinical models will also be discussed. Targeted genetic manipulation of certain metabolic or stress-response pathways, including one-carbon metabolism, NF-kappa B, PTEN and microRNAs, has been valuable in elucidating the pathways that regulate carcinogenesis in NAFLD. Although tremendous advances have occurred in the identification of diagnostic and therapeutic opportunities to reduce the progression of NAFLD, considerable gaps in our knowledge remain with regard to the mechanisms by which NAFLD and its risk factors promote liver cancer.
C1 [Michelotti, Gregory A.; Machado, Mariana V.; Diehl, Anna Mae] Duke Univ, Med Ctr, Div Gastroenterol, Dept Med, Durham, NC 27710 USA.
C3 Duke University
RP Diehl, AM (corresponding author), Duke Univ, Med Ctr, Div Gastroenterol, Dept Med, 595 LaSalle St,Snyderman Bldg,Suite 1073, Durham, NC 27710 USA.
EM diehl004@mc.duke.edu
OI , Gregory/0000-0002-3936-4675
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NR 145
TC 790
Z9 864
U1 3
U2 261
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 1759-5045
EI 1759-5053
J9 NAT REV GASTRO HEPAT
JI Nat. Rev. Gastroenterol. Hepatol.
PD NOV
PY 2013
VL 10
IS 11
BP 656
EP 665
DI 10.1038/nrgastro.2013.183
PG 10
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 247PW
UT WOS:000326632100007
PM 24080776
DA 2025-06-11
ER

PT J
AU Sullivan, S
AF Sullivan, Shelby
TI Implications of diet on nonalcoholic fatty liver disease
SO CURRENT OPINION IN GASTROENTEROLOGY
LA English
DT Article
DE fructose; hypercaloric diet; hypocaloric diet; n-3 polyunsaturated fat;
   nonalcoholic fatty liver disease; saturated fat; trans-fat
ID SERUM ALANINE AMINOTRANSFERASE; ENDOPLASMIC-RETICULUM STRESS; TERM
   HIGH-FAT; INSULIN-RESISTANCE; HEPATIC STEATOSIS; LOW-CARBOHYDRATE;
   WEIGHT-LOSS; TRIGLYCERIDE CONTENT; HEALTHY-MEN; METABOLIC SYNDROME
AB Purpose of review
   This review examines the effects of diet on nonalcoholic fatty liver disease (NAFLD). This includes the effects of calories, both in excess and restricted, as well as macronutrients.
   Recent findings
   Recent findings suggest that short-term hypercaloric feeding leads to increased intrahepatic triglyceride (IHTG), whereas short-term hypocaloric feeding leads to decreased IHTG, despite little change in total body weight, suggesting that ongoing excess caloric delivery directly contributes to the development of NAFLD. Weight loss with either low-fat or low-carbohydrate diets can improve IHTG; however, specific macronutrients, such as fructose, trans-fatty acids, and saturated fat, may contribute to increased IHTG independent of total calorie intake. n-3 polyunsaturated fatty acids and monounsaturated fatty acids may play a protective role in NAFLD. The mechanisms behind these effects are not fully understood.
   Summary
   Diet plays a role in the pathophysiology of NAFLD. It is reasonable to advise patients with NAFLD to reduce calorie intake with either low-fat or low-carbohydrate diets as well as limit intakes of fructose, trans-fatty acids, and saturated fat.
C1 [Sullivan, Shelby] Washington Univ, Sch Med, St Louis, MO 63110 USA.
C3 Washington University (WUSTL)
RP Sullivan, S (corresponding author), Washington Univ, Sch Med, Wohl Hosp, 4960 Childrens Pl,4th Floor, St Louis, MO 63110 USA.
EM ssulliva@dom.wustl.edu
FU NIDDK NIH HHS [P30 DK056341] Funding Source: Medline
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NR 62
TC 50
Z9 61
U1 1
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0267-1379
J9 CURR OPIN GASTROEN
JI Curr. Opin. Gastroenterol.
PD MAR
PY 2010
VL 26
IS 2
BP 160
EP 164
DI 10.1097/MOG.0b013e3283358a58
PG 5
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 562OW
UT WOS:000275063100014
PM 20010099
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Kowalska, I
AF Kowalska, Irina
TI Role of adipose tissue in the development of vascular complications in
   type 2 diabetes mellitus
SO DIABETES RESEARCH AND CLINICAL PRACTICE
LA English
DT Article; Proceedings Paper
CT 6th Regional Conference on the Treatment of Type 2 Diabetes Mellitus
CY SEP, 2006
CL Prague, CZECH REPUBLIC
DE adipocytokines; type 2 diabetes mellitus; cardiovascular complications
ID NECROSIS-FACTOR-ALPHA; INDUCED INSULIN-RESISTANCE; FREE FATTY-ACIDS;
   ACTIVATED PROTEIN-KINASE; PLASMA ADIPONECTIN CONCENTRATION; IMPAIRED
   GLUCOSE-TOLERANCE; CORONARY-ARTERY-DISEASE; TNF-ALPHA; OBESE SUBJECTS;
   METABOLIC SYNDROME
AB Type 2 diabetes mellitus (T2D) is considered one of the major metabolic diseases of the 21st century. Cardiovascular disease is the main cause of premature mortality and morbidity of T2D patients. The main mechanisms which could play a role in the pathogenesis of vascular complications are triggered by hyperglycaemia and hyperglycaemia-induced oxidative stress, however, during the past years a lot of attention has been paid to the potential role of adipose tissue in the development of vascular complications of diabetes. The several factors linking obesity with an increased cardiovascular risk have been identified. There is evidence that adipose tissue can be a source of proinflammatory cytokines, angiotensinogen and PAI-1 and other substances like leptin, resistin, adiponectin, visfatin, monocyte chemoattractant protein, retinal-binding protein-4. They could act directly by inducing inflammatory response; indirect effect is mediated through the development of insulin resistance. This review is focused on the role of several adipocytokines in the development of vascular complications of T2D. (c) 2007 Elsevier Ireland Ltd. All rights reserved.
C1 Med Univ Bialystok, Dept Endocrinol Diabetol & Internal Med, PL-15276 Bialystok, Poland.
C3 Medical University of Bialystok
RP Kowalska, I (corresponding author), Med Univ Bialystok, Dept Endocrinol Diabetol & Internal Med, Ul MC Sklodowskiej 24A, PL-15276 Bialystok, Poland.
EM irinak@poczta.onet.pl
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NR 113
TC 12
Z9 16
U1 1
U2 10
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0168-8227
EI 1872-8227
J9 DIABETES RES CLIN PR
JI Diabetes Res. Clin. Pract.
PD DEC 20
PY 2007
VL 78
SU 1
BP S14
EP S22
DI 10.1016/j.diabres.2007.10.007
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Endocrinology & Metabolism
GA 251RY
UT WOS:000252392800003
DA 2025-06-11
ER

PT J
AU Angulo, P
AF Angulo, P.
TI GI Epidemiology: nonalcoholic fatty liver disease
SO ALIMENTARY PHARMACOLOGY & THERAPEUTICS
LA English
DT Article
ID NATURAL-HISTORY; STEATOHEPATITIS; POPULATION; PREVALENCE; NAFLD;
   STEATOSIS; CIRRHOSIS; OUTCOMES; CHILDREN; RISK
AB Background Nonalcoholic fatty liver disease (NAFLD) is a common diagnosis in clinical practice. Insulin resistance and oxidative stress play an important role in NAFLD development and progression.
   Aim To review the data available on the epidemiology and natural history of NAFLD as well as the risk factors for its development and the areas where future research is necessary.
   Results/Conclusions NAFLD may affect individuals of any age range and race/ethnicity. NAFLD affects one in three adults and one in ten children/adolescents in the United States. Mortality in patients with NAFLD is significantly higher than in the general population of same age and gender with liver-related complications being a common cause of death. Liver-related morbidity and mortality in NAFLD occurs when the disease has progressed to advanced fibrosis and cirrhosis. Further studies are necessary to determine the impact of NAFLD on health-related quality of life and resources utilization, and to the extent to which preventing the development of the metabolic syndrome would prevent NAFLD development and reduce liver-related morbidity and mortality. Lifestyle intervention may improve NAFLD, but medications that increase insulin sensitivity and the antioxidant defenses in the liver deserve evaluation in carefully controlled trials.
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NR 23
TC 300
Z9 356
U1 1
U2 23
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0269-2813
EI 1365-2036
J9 ALIMENT PHARM THER
JI Aliment. Pharmacol. Ther.
PD APR 15
PY 2007
VL 25
IS 8
BP 883
EP 889
DI 10.1111/j.1365-2036.2007.03246.x
PG 7
WC Gastroenterology & Hepatology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Pharmacology & Pharmacy
GA 151SQ
UT WOS:000245311500003
PM 17402991
OA Bronze
DA 2025-06-11
ER

PT J
AU Li, X
   Liu, YF
   Liu, N
   Wu, HN
   Cong, KX
   Duan, LN
   Chen, TL
   Zhang, J
AF Li, Xiang
   Liu, Yufan
   Liu, Ning
   Wu, Hanning
   Cong, Kexin
   Duan, Linnan
   Chen, Tianli
   Zhang, Jie
TI Health benefits of medicinal plant natural products via
   microbiota-mediated different gut axes
SO PHARMACOLOGICAL RESEARCH
LA English
DT Article
DE Medicinal plant; Natural products; Gut microbiota; Health benefits
ID FATTY LIVER-DISEASE; BRAIN AXIS; LUNG AXIS; ACID; IMPROVES; OBESITY;
   ATHEROSCLEROSIS; PERMEABILITY; INFLAMMATION; METABOLISM
AB This review examines the multifaceted roles of medicinal plant natural products in influencing gut microbiota and their subsequent impact on various organ systems through established gut axes, including the gut-brain, gutliver, gut-heart, gut-lung, and gut-kidney axes. Medicinal plant natural products have exhibited diverse pharmacological activities, including modulation of microbiota composition, enhancement of metabolic processes, and alleviation of inflammation and oxidative stress. Evidence suggests that these components can ameliorate conditions such as neurological disorders, metabolic syndrome, and chronic kidney disease by restoring microbial balance and improving gut barrier integrity. Furthermore, the review highlights the potential of medicinal plant natural products to foster beneficial microbial communities and improve gut health, which may lead to reduced disease severity and inflammation. By comprehensively analyzing current literature, this review provides a foundation for future research aim at exploring the therapeutic applications of medicinal plant natural products in disease prevention and treatment. The findings underscore the need for further studies to elucidate the underlying mechanisms of action and validate the clinical efficacy of medicinal plant natural products in managing chronic conditions through gut microbiota modulation.
C1 [Li, Xiang; Liu, Yufan; Wu, Hanning; Cong, Kexin; Duan, Linnan] Jilin Univ, Coll Basic Med Sci, Dept Pharmacol, Changchun 130021, Peoples R China.
   [Liu, Ning] Jilin Canc Hosp, Dept Sect Off Breast Tumor 2, Changchun 130000, Peoples R China.
   [Chen, Tianli] Changchun Univ Chinese Med, Changchun 130000, Peoples R China.
   [Zhang, Jie] Jilin Univ, Coll Food Sci & Engn, Changchun 130062, Peoples R China.
C3 Jilin University; Changchun University of Chinese Medicine; Jilin
   University
RP Chen, TL (corresponding author), Changchun Univ Chinese Med, Changchun 130000, Peoples R China.; Zhang, J (corresponding author), Jilin Univ, Coll Food Sci & Engn, Changchun 130062, Peoples R China.
EM tli_chen@163.com; zhangjie83@jlu.edu.cn
FU Science and Technology Department of Jilin Province [20240602079RC];
   Bethune Project of Jilin Uni-versity [2024B16]; Li Xin Outstanding Young
   Teacher Training Program of Jilin University
FX This work was supported by the Science and Technology Department of
   Jilin Province (20240602079RC) , the Bethune Project of Jilin
   Uni-versity (2024B16) , and the Li Xin Outstanding Young Teacher
   Training Program of Jilin University.
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NR 165
TC 0
Z9 0
U1 3
U2 3
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 1043-6618
EI 1096-1186
J9 PHARMACOL RES
JI Pharmacol. Res.
PD MAY
PY 2025
VL 215
AR 107730
DI 10.1016/j.phrs.2025.107730
PG 39
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 1PY1G
UT WOS:001470869600001
PM 40216049
DA 2025-06-11
ER

PT J
AU Halabitska, I
   Babinets, L
   Oksenych, V
   Kamyshnyi, O
AF Halabitska, Iryna
   Babinets, Liliia
   Oksenych, Valentyn
   Kamyshnyi, Oleksandr
TI Diabetes and Osteoarthritis: Exploring the Interactions and Therapeutic
   Implications of Insulin, Metformin, and GLP-1-Based Interventions
SO BIOMEDICINES
LA English
DT Review
DE cartilage; insulin resistance; obesity; inflammation
ID ENDOPLASMIC-RETICULUM STRESS; PEPTIDE-1 RECEPTOR AGONIST; INFLAMMATORY
   RESPONSE; METABOLIC SYNDROME; CARTILAGE DEGENERATION; HAND
   OSTEOARTHRITIS; GLUCOSE-METABOLISM; CELL-FUNCTION; FATTY-ACIDS; BONE
   MASS
AB Diabetes mellitus (DM) and osteoarthritis (OA) are prevalent chronic conditions with shared pathophysiological links, including inflammation and metabolic dysregulation. This study investigates the potential impact of insulin, metformin, and GLP-1-based therapies on OA progression. Methods involved a literature review of clinical trials and mechanistic studies exploring the effects of these medications on OA outcomes. Results indicate that insulin, beyond its role in glycemic control, may modulate inflammatory pathways relevant to OA, potentially influencing joint health. Metformin, recognized for its anti-inflammatory properties via AMPK activation, shows promise in mitigating OA progression by preserving cartilage integrity and reducing inflammatory markers. GLP-1-based therapies, known for enhancing insulin secretion and improving metabolic profiles in DM, also exhibit anti-inflammatory effects that may benefit OA by suppressing cytokine-mediated joint inflammation and supporting cartilage repair mechanisms. Conclusions suggest that these medications, while primarily indicated for diabetes management, hold therapeutic potential in OA by targeting common underlying mechanisms. Further clinical trials are warranted to validate these findings and explore optimal therapeutic strategies for managing both DM and OA comorbidities effectively.
C1 [Halabitska, Iryna; Babinets, Liliia] I Horbachevsky Ternopil Natl Med Univ, Dept Therapy & Family Med, Voli Sq 1, UA-46001 Ternopol, Ukraine.
   [Oksenych, Valentyn] Univ Bergen, Dept Clin Sci, Broegelmann Res Lab, N-5020 Bergen, Norway.
   [Kamyshnyi, Oleksandr] I Horbachevsky Ternopil Natl Med Univ, Dept Microbiol Virol & Immunol, UA-46001 Ternopol, Ukraine.
C3 I. Horbachevsky Ternopil State Medical University; University of Bergen;
   I. Horbachevsky Ternopil State Medical University
RP Halabitska, I (corresponding author), I Horbachevsky Ternopil Natl Med Univ, Dept Therapy & Family Med, Voli Sq 1, UA-46001 Ternopol, Ukraine.; Oksenych, V (corresponding author), Univ Bergen, Dept Clin Sci, Broegelmann Res Lab, N-5020 Bergen, Norway.
EM halabitska@tdmu.edu.ua; valentyn.oksenych@uib.no;
   alexkamyshnyi@gmail.com
RI Kamyshnyi, Oleksandr/NES-8632-2025; Halabitska, Iryna/R-5739-2017;
   Kamyshnyi, Oleksandr/B-8583-2015; Oksenych, Valentyn/J-6216-2019;
   Babinets, Liliya/Q-5749-2016
OI Halabitska, Iryna/0000-0002-9028-7230; Kamyshnyi,
   Oleksandr/0000-0003-3141-4436; Oksenych, Valentyn/0000-0002-5088-3791;
   Babinets, Liliya/0000-0002-0560-1943
FX This research received no external funding.
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NR 233
TC 11
Z9 11
U1 0
U2 3
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2227-9059
J9 BIOMEDICINES
JI Biomedicines
PD AUG
PY 2024
VL 12
IS 8
AR 1630
DI 10.3390/biomedicines12081630
PG 23
WC Biochemistry & Molecular Biology; Medicine, Research & Experimental;
   Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Research & Experimental Medicine;
   Pharmacology & Pharmacy
GA E7U2P
UT WOS:001305012000001
PM 39200096
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Kiskin, FN
   Yang, Y
   Yang, H
   Zhang, JZ
AF Kiskin, Fedir N.
   Yang, Yuan
   Yang, Hao
   Zhang, Joe Z.
TI Cracking the code of the cardiovascular enigma: hPSC-derived endothelial
   cells unveil the secrets of endothelial dysfunction
SO JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
LA English
DT Article
DE Induced pluripotent stem cells; Endothelial cells; Endothelial
   dysfunction; Cardiovascular disease; Drug screening; Disease modeling
ID PLURIPOTENT STEM-CELLS; HEREDITARY HEMORRHAGIC TELANGIECTASIA; PULMONARY
   ARTERIAL-HYPERTENSION; NITRIC-OXIDE; SIGNALING PROMOTES;
   BASEMENT-MEMBRANE; PROGENITOR CELLS; VASCULAR CELLS; DIFFERENTIATION;
   GENE
AB Endothelial dysfunction is a central contributor to the development of most cardiovascular diseases and is characterised by the reduced synthesis or bioavailability of the vasodilator nitric oxide together with other abnormalities such as inflammation, senescence, and oxidative stress. The use of patient-specific and genomeedited human pluripotent stem cell-derived endothelial cells (hPSC-ECs) has shed novel insights into the role of endothelial dysfunction in cardiovascular diseases with strong genetic components such as genetic cardiomyopathies and pulmonary arterial hypertension. However, their utility in studying complex multifactorial diseases such as atherosclerosis, metabolic syndrome and heart failure poses notable challenges. In this review, we provide an overview of the different methods used to generate and characterise hPSC-ECs before comprehensively assessing their effectiveness in cardiovascular disease modelling and high-throughput drug screening. Furthermore, we explore current obstacles that will need to be overcome to unleash the full potential of hPSCECs in facilitating patient-specific precision medicine. Addressing these challenges holds great promise in advancing our understanding of intricate cardiovascular diseases and in tailoring personalised therapeutic strategies.
C1 [Kiskin, Fedir N.; Yang, Yuan; Yang, Hao; Zhang, Joe Z.] Shenzhen Bay Lab, Inst Neurol & Psychiat Disorders, Shenzhen 518132, Peoples R China.
C3 Shenzhen Bay Laboratory
RP Zhang, JZ (corresponding author), Shenzhen Bay Lab, Inst Neurol & Psychiat Disorders, Shenzhen 518132, Peoples R China.
EM fedirkiskin@szbl.ac.cn; yangyuan@szbl.ac.cn; yanghao@szbl.ac.cn;
   joezhang@szbl.ac.cn
RI zhang, joe/AAO-5273-2020
OI YANG, Hao/0009-0004-6703-1976
FU Guangdong Province International Science and Technology Cooperation
   Research Project [2023A0505050088]; National Natural Science Foundation
   of China General Program [82370311]
FX <B>Acknowledgements</B> This work was supported by Guangdong Province
   International Science and Technology Cooperation Research Project (Grant
   #2023A0505050088) and National Natural Science Foundation of China
   General Program (Grant #82370311) . Manuscript figures were created with
   BioRender.com .
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NR 162
TC 1
Z9 1
U1 3
U2 6
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 0022-2828
EI 1095-8584
J9 J MOL CELL CARDIOL
JI J. Mol. Cell. Cardiol.
PD JUL
PY 2024
VL 192
BP 65
EP 78
DI 10.1016/j.yjmcc.2024.05.005
EA MAY 2024
PG 14
WC Cardiac & Cardiovascular Systems; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Cell Biology
GA TV1C6
UT WOS:001243933600001
PM 38761989
DA 2025-06-11
ER

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   Zhang, Liqiong
   Lu, Haibin
   Zhang, Yinyi
TI Characteristics of mesoscale eddies in the Mozambique Channel
SO PLOS ONE
LA English
DT Article
ID METABOLIC SYNDROME; PSORIASIS; PREVALENCE; RISK
AB The mesoscale eddy characteristics of the Mozambique Warm Current were investigated by detecting and tracking satellite altimetry data from 2010 to 2019. A total of 1,086 eddies were identified in the Mozambique Channel, comprising 509 cyclonic eddies and 577 anticyclonic eddies. The results revealed that the bay area on the northwest coast of Madagascar was the main hotspot of eddy generation, and the mean amplitude and radius of the anticyclonic eddies in the Mozambique Channel were 24.23 cm and 82.7 km, respectively, which are larger than those of the cyclonic eddies. Local wind forcing had a significant impact on the formation of mesoscale eddies in the Mozambique Channel. In winter, the wind stress in the northern and southern areas of the Mozambique Channel exhibited a strong correlation with the distribution of eddy kinetic energy (EKE), where both monsoonal winds in the north and trade winds in the south could facilitate mesoscale anticyclonic eddy formation. In addition, the variability in the number of anticyclonic and cyclonic eddies in the Mozambique Channel may have exerted a significant influence on the seasonal anomalous fluctuations in local sea surface temperatures (SSTs). This study presented a novel analysis of the mesoscale eddy characteristics in the Mozambique Channel.
C1 [Bai, Linfei; Lu, Haibin] Jiangsu Ocean Univ, Jiangsu Key Lab Marine Bioresources & Environm, Jiangsu Key Lab Marine Biotechnol, Lianyungang, Jiangsu, Peoples R China.
   [Bai, Linfei; Zhu, Guohao; Huang, Haojie; Zhang, Liqiong; Lu, Haibin] Jiangsu Ocean Univ, Sch Marine Technol & Geomat, Lianyungang, Jiangsu, Peoples R China.
   [Bai, Linfei; Zhang, Yinyi] Lianyungang Meteorol Bur, Lianyungang, Jiangsu, Peoples R China.
   [Lu, Haibin] Jiangsu Ocean Univ, Coinnovat Ctr Jiangsu Marine Bioind Technol, Lianyungang, Jiangsu, Peoples R China.
C3 Jiangsu Ocean University; Jiangsu Ocean University; Jiangsu Ocean
   University
RP Lü, HB (corresponding author), Jiangsu Ocean Univ, Jiangsu Key Lab Marine Bioresources & Environm, Jiangsu Key Lab Marine Biotechnol, Lianyungang, Jiangsu, Peoples R China.; Lü, HB (corresponding author), Jiangsu Ocean Univ, Sch Marine Technol & Geomat, Lianyungang, Jiangsu, Peoples R China.; Lü, HB (corresponding author), Jiangsu Ocean Univ, Coinnovat Ctr Jiangsu Marine Bioind Technol, Lianyungang, Jiangsu, Peoples R China.
OI LU, Haibin/0000-0002-0951-1363
FU Priority Academic Program Development of Jiangsu Higher Education
   Institutions (PAPD); Postgraduate Research & Practice Innovation Program
   of Jiangsu Ocean University [KYCX2022-29]; Postgraduate Research and
   Practice Innovation Program of Jiangsu Province [SJCX23_1818]; National
   Natural Science Foundation of China [41976187]
FX This work was funded by the Priority Academic Program Development of
   Jiangsu Higher Education Institutions (PAPD), Postgraduate Research &
   Practice Innovation Program of Jiangsu Ocean University (Grants numbers
   KYCX2022-29), Postgraduate Research and Practice Innovation Program of
   Jiangsu Province (Grants no. SJCX23_1818) and National Natural Science
   Foundation of China (Grants no. 41976187).
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NR 38
TC 0
Z9 0
U1 1
U2 4
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD APR 29
PY 2024
VL 19
IS 4
AR e0302367
DI 10.1371/journal.pone.0302367
PG 12
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA PK9W0
UT WOS:001214099700030
PM 38683798
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Fragoso-Medina, JA
   Vaquera, SRL
   Domínguez-Uscanga, A
   Luna-Vital, D
   García, N
AF Fragoso-Medina, Jorge Alberto
   Vaquera, Selma Romina Lopez
   Dominguez-Uscanga, Astrid
   Luna-Vital, Diego
   Garcia, Noemi
TI Single anthocyanins effectiveness modulating inflammation markers in
   obesity: dosage and matrix composition analysis
SO FRONTIERS IN NUTRITION
LA English
DT Review
DE antioxidants; anti-inflammatories; anthocyanins bioactivities;
   anthocyanins composition; single anthocyanins doses; inflammation
   markers
ID INDUCED OXIDATIVE STRESS; IMPROVED LIPID PROFILE; LOW-GRADE
   INFLAMMATION; KAPPA-B ACTIVATION; DOUBLE-BLIND; METABOLIC SYNDROME;
   BLOOD-PRESSURE; HYPERLIPIDEMIC PATIENTS; ANTIOXIDANT CAPACITY;
   INSULIN-RESISTANCE
AB Anthocyanins (ACNs) are phytochemicals with numerous bioactivities, e.g., antioxidant and anti-inflammatory. Health benefits from consuming ACN-rich foods, extracts, and supplements have been studied in clinical trials (CT). However, the individual effect of single ACNs and their correlation with doses and specific bioactivities or molecular targets have not been thoroughly analyzed. This review shows a recompilation of single anthocyanins composition and concentrations used in CT, conducted to investigate the effect of these anti-inflammatory derivatives in obese condition. Single anthocyanin doses with changes in the levels of frequently monitored markers were correlated. In addition, the analysis was complemented with reports of studies made in vitro with single ACNs. Anthocyanins' efficacy in diseases with high baseline obesity-related inflammation markers was evidenced. A poor correlation was found between most single anthocyanin doses and level changes of commonly monitored markers. Correlations between cyanidin, delphinidin, and pelargonidin derivatives and specific molecular targets were proposed. Our analysis showed that knowledge of specific compositions and anthocyanin concentrations determined in future studies would provide more information about mechanisms of action.
C1 [Fragoso-Medina, Jorge Alberto; Vaquera, Selma Romina Lopez; Dominguez-Uscanga, Astrid; Luna-Vital, Diego; Garcia, Noemi] Tecnol Monterrey, Inst Obes Res, Monterrey, Mexico.
   [Fragoso-Medina, Jorge Alberto; Vaquera, Selma Romina Lopez; Garcia, Noemi] Tecnol Monterrey, Sch Med & Hlth Sci, Monterrey, Mexico.
   [Dominguez-Uscanga, Astrid; Luna-Vital, Diego] Tecnol Monterrey, Sch Engn & Sci, Monterrey, Mexico.
   [Garcia, Noemi] Tecnol Monterrey, Preclin Res Unit, Monterrey, Mexico.
C3 Tecnologico de Monterrey; Tecnologico de Monterrey; Tecnologico de
   Monterrey; Tecnologico de Monterrey
RP Fragoso-Medina, JA (corresponding author), Tecnol Monterrey, Inst Obes Res, Monterrey, Mexico.; Fragoso-Medina, JA (corresponding author), Tecnol Monterrey, Sch Med & Hlth Sci, Monterrey, Mexico.
EM jorge.fragoso@tec.mx
RI Luna-Vital, Diego/B-9634-2015
OI Lopez Vaquera, Selma Romina/0000-0003-1443-876X
FU This manuscript was supported by the Institute for Obesity Research
   -Tecnologico de Monterrey (seed funding and grant I017-IOR004-C6-T3-E)
   and the Young Investigator Award on Food Science and Technology 2021
   from the Mexican Academy of Sciences received by [I017-IOR004-C6-T3-E];
   Institute for Obesity Research -Tecnologico de Monterrey
FX The authors acknowledge the support provided by the School of Medicine
   and Health Sciences and the School of Engineering and Sciences -
   Tecnologico de Monterrey.r This manuscript was supported by the
   Institute for Obesity Research -Tecnologico de Monterrey (seed funding
   and grant I017-IOR004-C6-T3-E) and the Young Investigator Award on Food
   Science and Technology 2021 from the Mexican Academy of Sciences
   received by DL-V.
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NR 136
TC 2
Z9 2
U1 1
U2 6
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD NOV 2
PY 2023
VL 10
AR 1255518
DI 10.3389/fnut.2023.1255518
PG 20
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA Y0BG0
UT WOS:001102002800001
PM 38024376
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Ghzaiel, I
   Sassi, K
   Zarrouk, A
   Ghosh, S
   Dias, IHK
   Nury, T
   Ksila, M
   Essadek, S
   Joutey, MT
   Brahmi, F
   Mihoubi, W
   Rup-Jacques, S
   Samadi, M
   Rezig, L
   Meziane, S
   Ghrairi, T
   Masmoudi-Kouki, O
   Hammami, S
   Nasser, B
   Hammami, M
   Wang, YQ
   Griffiths, WJ
   Vejux, A
   Lizard, G
AF Ghzaiel, Imen
   Sassi, Khouloud
   Zarrouk, Amira
   Ghosh, Shubhrima
   Dias, Irundika H. K.
   Nury, Thomas
   Ksila, Mohamed
   Essadek, Soukaina
   Joutey, Mounia Tahri
   Brahmi, Fatiha
   Mihoubi, Wafa
   Rup-Jacques, Sandrine
   Samadi, Mohammad
   Rezig, Leila
   Meziane, Smail
   Ghrairi, Taoufik
   Masmoudi-Kouki, Olfa
   Hammami, Sonia
   Nasser, Boubker
   Hammami, Mohamed
   Wang, Yuqin
   Griffiths, William J.
   Vejux, Anne
   Lizard, Gerard
TI Sources of 7-ketocholesterol, metabolism and inactivation strategies:
   food and biomedical applications
SO REDOX EXPERIMENTAL MEDICINE
LA English
DT Review
DE age-related diseases; bioremediation; 7-ketocholesterol; metabolism;
   nutrition
ID CHOLESTEROL OXIDATION-PRODUCTS; ALPHA-TOCOPHEROL; ENDOTHELIAL-CELLS;
   INFLAMMATORY CYTOKINES; MEDICAL BIOREMEDIATION; APOPTOSIS INDUCTION;
   MASS-SPECTROMETRY; POTENTIAL ROLE; FATTY-ACIDS; OXYSTEROLS
AB 7-Ketocholesterol (or 7-oxocholesterol) is an oxysterol essentially formed by cholesterol autoxidation. It is often found at enhanced levels in the body fluids and/or target tissues of patients with age-related diseases (cardiovascular, neuronal, and ocular diseases) as well as in subjects concerned with civilization diseases (type 2 diabetes, bowel diseases, and metabolic syndrome). The involvement of increased 7-ketocholesterol levels in the pathophysiology of these diseases is widely suspected. Indeed, 7-ketocholesterol at elevated concentrations is a powerful inducer of oxidative stress, inflammation, and cellular degeneration which are common features of all these diseases. It is important to better know the origin of 7-ketocholesterol (diet, incidence of environmental factors, and endogenous formation (autoxidation and enzymatic synthesis)) and its inactivation mechanisms which include esterification, sulfation, oxidation, and reduction. This knowledge will make it possible to act at different levels to regulate 7-ketocholesterol level and counteract its toxicity in order to limit the incidence of diseases associated with this oxysterol. These different points as well as food and biomedical applications are addressed in this review.
C1 [Ghzaiel, Imen; Sassi, Khouloud; Nury, Thomas; Ksila, Mohamed; Essadek, Soukaina; Joutey, Mounia Tahri; Vejux, Anne; Lizard, Gerard] Univ Bourgogne Franche Comte, Team Biochem Peroxisome Inflammat & Lipid Metab EA, Inserm, Dijon, France.
   [Ghzaiel, Imen; Zarrouk, Amira; Hammami, Sonia; Hammami, Mohamed] Univ Monastir, Fac Med, Lab NAFS Nutr Funct Food & Vasc Hlth, Monastir, Tunisia.
   [Ghzaiel, Imen] Univ Tunis El Manar, Fac Sci Tunis, Tunis, Tunisia.
   [Zarrouk, Amira] Univ Sousse, Fac Med, Sousse, Tunisia.
   [Ghosh, Shubhrima] Univ Dublin, Trinity Coll Dublin, Sch Pharm & Pharmaceut Sci, Coll Green, Dublin, Ireland.
   [Dias, Irundika H. K.] Aston Univ, Aston Med Sch, Birmingham, England.
   [Ksila, Mohamed; Ghrairi, Taoufik; Masmoudi-Kouki, Olfa] Univ Tunis El Manar, Fac Sci, Dept Biol, Lob Neurophysiol, LR18ES03, Tunis, Tunisia.
   [Essadek, Soukaina; Joutey, Mounia Tahri; Nasser, Boubker] Univ Hassan I, Fac Sci & Tech, Lab Biochem Neurosci Nat Resources & Environm, Settat, Morocco.
   [Brahmi, Fatiha] Univ Bejaia, Fac Sci Nat & Vie, Lab Biomath Biochim Biophys & Scientometr, Bejaia, Algeria.
   [Mihoubi, Wafa] Univ Sfax, Ctr Biotechnol Sfax, Lab Biotechnol Mol Eucaryotes, Sfax, Tunisia.
   [Rup-Jacques, Sandrine; Samadi, Mohammad] Univ Lorraine, Dept Chem, ICPM, LCPMC A2, Metz Technopole, Metz, France.
   [Rezig, Leila] Univ Carthage, Natl Inst Appl Sci & Technol, LIP MB Lab Prot Engn & Bioact Mol, LR11ES26, Tunis, Tunisia.
   [Rezig, Leila] Univ Carthage, High Inst Food Ind, Tunis, Tunisia.
   [Meziane, Smail] Inst Europeen Antioxydants, Maisons, France.
   [Wang, Yuqin; Griffiths, William J.] Swansea Univ, Med Sch, Swansea, Wales.
C3 Institut National de la Sante et de la Recherche Medicale (Inserm);
   Universite Bourgogne Europe; Universite de Monastir; Universite de
   Tunis-El-Manar; Faculte des Sciences de Tunis (FST); Universite de
   Sousse; Trinity College Dublin; Aston University; Universite de
   Tunis-El-Manar; Faculte des Sciences de Tunis (FST); Hassan First
   University of Settat; Universite de Bejaia; Universite de Sfax; Centre
   de Biotechnologie de Sfax; Universite de Lorraine; Universite de
   Carthage; Universite de Carthage; Swansea University
RP Lizard, G (corresponding author), Univ Bourgogne Franche Comte, Team Biochem Peroxisome Inflammat & Lipid Metab EA, Inserm, Dijon, France.
EM gerard.lizard@u-bourgogne.fr
RI Vejux, Anne/C-1509-2019; REZIG, Leila/GRY-6373-2022; Brahmi,
   Fatiha/AAF-6758-2019; NURY, THOMAS/IZQ-3626-2023; De Dios Alche,
   Juan/K-6079-2014; Amira, Zarrouk/AFN-1200-2022; Liu, Zexian/D-1153-2011
OI SASSI, Khouloud/0000-0003-3372-0242; Dias, Irundika/0000-0002-6620-8221
FU Universite de Bourgogne (Dijon, France); Universite Tunis El Manar
   (Tunis, Tunisia); Universite de Monastir (Monastir, Tunisia); Universite
   Hassan 1 er (Settat, Morocco); PHC UTIQUE 2021-2022 [CMCU: 22G0809,
   47608VJ]; ABASIM (Association Bourguignonne pour les Applications des
   Sciences de l'Information en Medecine; Dijon, France)
FX Thisworkwas funded by Universite de Bourgogne (Dijon, France),
   Universite Tunis El Manar (Tunis, Tunisia), Universite de Monastir
   (Monastir, Tunisia), and Universite Hassan 1 er (Settat, Morocco). This
   work was supported by PHC UTIQUE 2021-2022 (Dr Taoufik Ghrairi, Tunisia
   and Dr Gerard Lizard, France; code CMCU: 22G0809/Code Campus France:
   47608VJ). Imen Ghzaiel also received financial support from ABASIM
   (Association Bourguignonne pour les Applications des Sciences de
   l'Information en Medecine; Dijon, France).
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NR 158
TC 26
Z9 26
U1 0
U2 0
PU BIOSCIENTIFICA LTD
PI BRISTOL
PA STARLING HOUSE, 1600 BRISTOL PARKWAY N, BRISTOL, ENGLAND
EI 2755-158X
J9 REDOX EXP MED
JI Redox Exp. Med.
PD JUL 1
PY 2022
VL 2022
IS 1
BP R40
EP R56
DI 10.1530/REM-22-0005
PG 17
WC Biochemistry & Molecular Biology; Medicine, Research & Experimental
WE Emerging Sources Citation Index (ESCI)
SC Biochemistry & Molecular Biology; Research & Experimental Medicine
GA J4F2Z
UT WOS:001336632900003
OA Green Accepted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Pretorius, E
AF Pretorius, E.
TI Erythrocyte deformability and eryptosis during inflammation, and
   impaired blood rheology
SO CLINICAL HEMORHEOLOGY AND MICROCIRCULATION
LA English
DT Article; Proceedings Paper
CT 1st Hemorheology Days of
   European-Society-of-Clinical-Hemorheology-and-Microcirculation (ESCHM)
CY JUL 19-21, 2017
CL Puchberg, AUSTRIA
SP European Soc Clin Hemorheol & Microcirculat
DE Infalmmation; eryptosis; erythrocytes; rheology
ID TRANSIENT ISCHEMIC ATTACK; SYSTEMIC INFLAMMATION; METABOLIC SYNDROME;
   ENDOTHELIAL-CELLS; OXIDATIVE STRESS; TISSUE FACTOR; PLATELETS; FIBRIN;
   IRON; THROMBOSIS
AB OBJECTIVE: This review focusses on the erythrocytes (RBCs) and their structural changes during inflammation and impaired blood rheology. We discuss systemic inflammation and the effects of dysregulated inflammatory molecules. These pro-inflammatory molecules directly affect the haematological system, and particularly the RBCs, platelets and plasma proteins. We focus on the three main changes; increased RBC eryptosis (programmed cell death, similar to apoptosis) and pathological deformability, platelet hyperreactivity and anomalous blood clotting, due to pathological changes to fibrin(ogen) protein structure. This pro-inflammatory haematological system directly affects blood rheology. In turn, hemorheological parameters such as RBC deformability are important parameters in hypercoagulation, which is a hallmark of inflammation. For RBC deformation to happen during blood flow, the RBC membrane needs to be elastic to elongate sufficiently to squeeze through small capillaries. However, of greater importance is that the cell must return to its original biconcave shape after exiting the small diameter capillaries.
   CONCLUSION: Hemorheological parameters such as RBC deformability are of great importance clinically, to both identify the presence and extent of inflammation, and to study these parameters during intervention therapies. RBC rheology and deformability may therefore be a useful cell model for pharmaceutical testing.
C1 [Pretorius, E.] Stellenbosch Univ, Dept Physiol Sci, Private Bag X1 Matieland, Stellenbosch, South Africa.
C3 Stellenbosch University
RP Pretorius, E (corresponding author), Stellenbosch Univ, Fac Sci, Dept Physiol Sci, Private Bag X1 Matieland, ZA-7602 Stellenbosch, South Africa.
EM resiap@sun.ac.za
RI Pretorius, Etheresia/ACH-6368-2022
FU National Research Foundation (NRF) of South Africa [91548]; South
   African Medical Research Council (SIR grant)
FX The author thanks the National Research Foundation (NRF) of South Africa
   (91548: Competitive Program) and the South African Medical Research
   Council (SIR grant). This study was presented at the 1st Hemorheology
   Days in Puchberg, Austria, July 19-21, 2017.
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NR 38
TC 52
Z9 53
U1 2
U2 10
PU IOS PRESS
PI AMSTERDAM
PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS
SN 1386-0291
EI 1875-8622
J9 CLIN HEMORHEOL MICRO
JI Clin. Hemorheol. Microcirc.
PY 2018
VL 69
IS 4
BP 545
EP 550
DI 10.3233/CH-189205
PG 6
WC Hematology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Hematology; Cardiovascular System & Cardiology
GA GQ8LF
UT WOS:000442005500010
PM 29710698
DA 2025-06-11
ER

PT J
AU Li, XN
   Lin, J
   Xia, J
   Qin, L
   Zhu, SY
   Li, JL
AF Li, Xue-Nan
   Lin, Jia
   Xia, Jun
   Qin, Lei
   Zhu, Shi-Yong
   Li, Jin-Long
TI Lycopene mitigates atrazine-induced cardiac inflammation via blocking
   the NF-κB pathway and NO production
SO JOURNAL OF FUNCTIONAL FOODS
LA English
DT Article
DE Lycopene; Atrazine; Heart; Inflammatory response; NO production;
   NF-kappa B pathway
ID ZEBRAFISH DANIO-RERIO; INDUCED DIABETIC-RATS; NITRIC-OXIDE; OXIDATIVE
   STRESS; TOMATO PRODUCTS; ENDOTHELIAL DYSFUNCTION;
   CARDIOVASCULAR-DISEASES; METABOLIC SYNDROME; IONIC HOMEOSTASIS; MEDIA
   THICKNESS
AB LYC (lycopene) plays roles in preventing heart disease. Epidemiological studies report that ATR (atrazine)-induced cardiac inflammation is associated with an increase in cardiovascular mortality. However, true confirmation that cardioprotective effects of LYC against ATR-induced heart injury occured through modulation of the inflammation response is lacking. Mice were treated with LYC (5 mg/kg) and/or ATR (50 or 200 mg/kg) by gavage administration for 21 days. These results indicated that LYC significantly protected the heart against ATR-induced histological alterations, including increased NO (nitric oxide) content and NOS (nitric oxide synthase) activities, up-regulation of pro-inflammatory and down-regulation of anti-inflammatory cytokines and activation of the TRAF6-NF-kappa B pathway. ATR induced cardiac damage via enhancing NO production and triggering the inflammatory response. Supplementary LYC significantly alleviated the cardiac injury via modulating NO and NO-generating systems and blocking the TRAF6-NF-kappa B pathway. Therefore, LYC showed significant chemoprotective potential against ATR-induced cardiac injury via suppressing the inflammatory response. (C) 2016 Elsevier Ltd. All rights reserved.
C1 [Li, Xue-Nan; Lin, Jia; Xia, Jun; Qin, Lei; Zhu, Shi-Yong; Li, Jin-Long] Northeast Agr Univ, Coll Vet Med, Harbin 150030, Peoples R China.
   [Xia, Jun] Qiqihar Med Univ, Lab Anim Ctr, Qiqihar 161006, Peoples R China.
C3 Northeast Agricultural University - China; Qiqihar Medical University
RP Li, JL (corresponding author), Northeast Agr Univ, Coll Vet Med, Harbin 150030, Peoples R China.
EM Jinlongli@neau.edu.cn
RI xia, jun/ABG-4188-2020
OI li, xuenan/0000-0002-8206-7633
FU China New Century Excellent Talents in University [NECT-1207-02];
   Program for New Century Excellent Talents In Heilongjiang Provincial
   University [1252-NCET-009]; National Natural Science Foundation of China
   [31572586]; Academic Backbone Project of Northeast Agricultural
   University [15XG16]
FX This work was supported by China New Century Excellent Talents in
   University (No. NECT-1207-02), Program for New Century Excellent Talents
   In Heilongjiang Provincial University (No. 1252-NCET-009), National
   Natural Science Foundation of China (No. 31572586) and Academic Backbone
   Project of Northeast Agricultural University (No. 15XG16). We also
   acknowledge the valuable help provided by Prof. Shi-Wen Xu in Northeast
   Agricultural University and all of the workers involved.
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NR 75
TC 39
Z9 41
U1 3
U2 26
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1756-4646
J9 J FUNCT FOODS
JI J. Funct. Food.
PD FEB
PY 2017
VL 29
BP 208
EP 216
DI 10.1016/j.jff.2016.12.029
PG 9
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA EK3SN
UT WOS:000393847800025
DA 2025-06-11
ER

PT J
AU Da Pozzo, E
   Costa, B
   Cavallini, C
   Testai, L
   Martelli, A
   Calderone, V
   Martini, C
AF Da Pozzo, Eleonora
   Costa, Barbara
   Cavallini, Chiara
   Testai, Lara
   Martelli, Alma
   Calderone, Vincenzo
   Martini, Claudia
TI The Citrus Flavanone Naringenin Protects Myocardial Cells against
   Age-Associated Damage
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Article
ID ESTROGEN-RECEPTOR-ALPHA; H9C2 CELLS; MITOCHONDRIAL DYSFUNCTION; INDUCED
   CARDIOTOXICITY; CELLULAR SENESCENCE; POTASSIUM CHANNELS; METABOLIC
   SYNDROME; OXIDATIVE STRESS; ORANGE JUICE; DNA-DAMAGE
AB In recent years, the health-promoting effects of the citrus flavanone naringenin have been examined. The results have provided evidence for the modulation of some key mechanisms involved in cellular damage by this compound. In particular, naringenin has been revealed to have protective properties such as an antioxidant effect in cardiometabolic disorders. Very recently, beneficial effects of naringenin have been demonstrated in old rats. Because aging has been demonstrated to be directly related to the occurrence of cardiac disorders, in the present study, the ability of naringenin to prevent cardiac cell senescence was investigated. For this purpose, a cellular model of senescent myocardial cells was set up and evaluated using colorimetric, fluorimetric, and immunometric techniques. Relevant cellular senescence markers, such as X-gal staining, cell cycle regulator levels, and the percentage of cell cycle-arrested cells, were found to be reduced in the presence of naringenin. In addition, cardiac markers of aging-induced damage, including radical oxidative species levels, mitochondrial metabolic activity, mitochondrial calcium buffer capacity, and estrogenic signaling functions, were also modulated by the compound. These results suggested that naringenin has antiaging effects on myocardial cells.
C1 [Da Pozzo, Eleonora; Costa, Barbara; Cavallini, Chiara; Testai, Lara; Martelli, Alma; Calderone, Vincenzo; Martini, Claudia] Univ Pisa, Dept Pharm, Pisa, Italy.
   [Da Pozzo, Eleonora; Costa, Barbara; Testai, Lara; Martelli, Alma; Calderone, Vincenzo; Martini, Claudia] Univ Pisa, Interdept Res Ctr Nutraceuticals & Food Hlth, Pisa, Italy.
C3 University of Pisa; University of Pisa
RP Da Pozzo, E (corresponding author), Univ Pisa, Dept Pharm, Pisa, Italy.; Da Pozzo, E (corresponding author), Univ Pisa, Interdept Res Ctr Nutraceuticals & Food Hlth, Pisa, Italy.
EM eleonora.dapozzo@unipi.it
RI Cavallini, Chiara/ABC-9438-2020; Martelli, Alma/H-6557-2019; Martini,
   Claudia/AAC-4089-2019; Da Pozzo, Eleonora/AAW-8186-2020; Da Pozzo,
   Eleonora/M-2215-2015; CALDERONE, VINCENZO/L-9288-2015
OI testai, lara/0000-0003-2431-6248; Da Pozzo,
   Eleonora/0000-0003-4762-8949; Cavallini, Chiara/0000-0002-3456-5152;
   CALDERONE, VINCENZO/0000-0002-1441-5421; COSTA,
   BARBARA/0000-0002-7598-1275; Martelli, Alma/0000-0002-2090-7107;
   Martini, Claudia/0000-0001-9379-3027
FU University of Pisa (Progetti di Ricerca di Ateneo (PRA))
FX Funding for this study was provided by the University of Pisa (Progetti
   di Ricerca di Ateneo (PRA)).
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NR 74
TC 65
Z9 67
U1 0
U2 14
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PY 2017
VL 2017
AR 9536148
DI 10.1155/2017/9536148
PG 12
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA EQ7HQ
UT WOS:000398255500001
PM 28386313
OA Green Published, Green Submitted, hybrid
DA 2025-06-11
ER

PT J
AU Li, XL
   Xu, JH
AF Li, Xinli
   Xu, Jiuhong
TI Lycopene Supplement and Blood Pressure: An Updated Meta-Analysis of
   Intervention Trials
SO NUTRIENTS
LA English
DT Article
DE lycopene; blood pressure; intervention trials; meta-analysis
ID CAROTENOID CONCENTRATIONS; NATURAL ANTIOXIDANTS; METABOLIC SYNDROME;
   OXIDATIVE STRESS; LOWER PREVALENCE; TOMATO EXTRACT; HUMAN HEALTH;
   HYPERTENSION; SERUM; RISK
AB Epidemiological studies suggested that lycopene supplement could decrease blood pressure, but the results were conflicting. We conducted an updated meta-analysis by screening PubMed databases, and calculated the combined effect size using a random effect model. In addition, subgroup analysis stratified by baseline blood pressure, lycopene dosage, duration, study location and the funding support of the paper was also conducted. Six studies met our inclusion criteria, and the pooled analysis demonstrated a significant reduction of systolic blood pressure (SBP) (mean SBP = -4.953 [-8.820, -1.086], p = 0.012) with obvious heterogeneity (p = 0.034, I-2 = 58.5%). Subgroup analysis results showed that higher dosage of lycopene supplement (>12 mg/day) could lower SBP more significantly, especially for participants with baseline SBP >120 mmHg, or Asians, while lycopene intervention had no statistical effect on diastolic blood pressure (DBP) (mean DBP = -3.809 [-8.177, 0.560], p = 0.087), and obvious heterogeneity was also observed (p = 0.074, I-2 = 53.1%). Our present study suggests that lycopene supplement >12 mg/day might effectively decrease SBP, particularly among Asians or population with higher baseline SBP.
C1 [Li, Xinli] Soochow Univ, Coll Med, Sch Publ Hlth, Suzhou 215123, Peoples R China.
   [Xu, Jiuhong] Soochow Univ, Dept Radiotherapy, Affiliated Hosp 1, Suzhou 215006, Peoples R China.
C3 Soochow University - China; Soochow University - China
RP Li, XL (corresponding author), Soochow Univ, Coll Med, Sch Publ Hlth, Suzhou 215123, Peoples R China.
EM lixinli@suda.edu.cn; xujiuhong@suda.edu.cn
FU National Natural Science Foundation of China [81001185, 81372980];
   Universities Natural Science Foundation of Kiangs Province
   [10KJB310011]; Priority Academic Program Development of Jiangsu Higher
   Education Institutions (PAPD)
FX This work was supported by grants from the National Natural Science
   Foundation of China (No_81001185) and (No_81372980), Universities
   Natural Science Foundation of Kiangs Province (No_10KJB310011), and
   Priority Academic Program Development of Jiangsu Higher Education
   Institutions (PAPD).
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NR 42
TC 43
Z9 44
U1 0
U2 21
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD SEP
PY 2013
VL 5
IS 9
BP 3696
EP 3712
DI 10.3390/nu5093696
PG 17
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 274SW
UT WOS:000328627500024
PM 24051501
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Bis-Wencel, H
   Lopuszynski, W
   Saba, L
   Bryl, M
   Rowicka, A
AF Bis-Wencel, Hanna
   Lopuszynski, Wojciech
   Saba, Leon
   Bryl, Monika
   Rowicka, Agnieszka
TI HISTOPATHOLOGICAL EXAMINATION OF SELECTED INTERNAL ORGANS OF PASTEL
   MINKS IN RELATION TO OXIDATIVE STATE PARAMETERS
SO BULLETIN OF THE VETERINARY INSTITUTE IN PULAWY
LA English
DT Article
DE female mink; obesity; oxidative state
ID METABOLIC SYNDROME; MUSTELA-VISON; STRESS; IMPACT
AB The aim of the study was histopathological characteristics of mink females showing a tendency to decrease body condition in a perinatal period against a background of selected parameters of antioxidant state. The minks were divided into two groups according to body condition scoring system (BCS). The blood was collected twice: after weaning and at the end of the production cycle. The serum activity of oxidative state enzymes was determined. Anatomic and histopathological examinations were conducted after the production cycle. Samples of the liver, kidneys, small intestine, and ovaries were fixed in 10% buffered formalin and stained with haematoxylin-eosin and Sudan IV. The histopathological examinations revealed hyperaemia of the liver and kidneys, with large content of blood in the capillary and central vessels of obese females. The kidney structure was normal in animals of experimental group. On the other hand, kidneys of control group animals showed degenerative changes in the epithelial cells of the tubules of the excretory pan, especially of the proximal tubules. Against the background of the obtained results, it should be stated that lower activities of selected enzymes with anatomical and histopathological changes were obtained in the animals with worse body condition.
C1 [Bis-Wencel, Hanna; Saba, Leon; Bryl, Monika; Rowicka, Agnieszka] Univ Life Sci Lublin, Dept Anim & Environm Hyg, Fac Vet Med, PL-20950 Lublin, Poland.
   [Lopuszynski, Wojciech] Univ Life Sci Lublin, Dept Pathol Anat, Fac Vet Med, PL-20950 Lublin, Poland.
C3 University of Life Sciences in Lublin; University of Life Sciences in
   Lublin
RP Bis-Wencel, H (corresponding author), Univ Life Sci Lublin, Dept Anim & Environm Hyg, Fac Vet Med, PL-20950 Lublin, Poland.
EM hanna.biswencel@up.lublin.pl
RI Lopuszynski, Wojciech/KPY-7074-2024
OI Bis-Wencel, Hanna/0000-0003-1425-3378
CR BISWENCEL H, 2004, P 8 INT SCI C AN PRO, P68
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NR 15
TC 1
Z9 1
U1 0
U2 0
PU NATL VETERINARY RESEARCH INST
PI PULAWY
PA C/O PUBICATIONS OFFICE, 24-100 PULAWY, POLAND
SN 0042-4870
J9 B VET I PULAWY
JI Bull. Vet. Inst. Pulawy
PY 2010
VL 54
IS 4
BP 651
EP 654
PG 4
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA 705VL
UT WOS:000286168700036
DA 2025-06-11
ER

PT J
AU Baltazar, P
   de Melo, AF Jr
   Fonseca, NM
   Lanca, MB
   Faria, A
   Sequeira, CO
   Teixeira-Santos, L
   Monteiro, EC
   Pinheiro, LC
   Calado, J
   Sousa, C
   Morello, J
   Pereira, SA
AF Baltazar, Pedro
   de Melo Jr, Antonio Ferreira
   Fonseca, Nuno Moreira
   Lanca, Miguel Brito
   Faria, Ana
   Sequeira, Catarina O.
   Teixeira-Santos, Luisa
   Monteiro, Emilia C.
   Campos Pinheiro, Luis
   Calado, Joaquim
   Sousa, Catia
   Morello, Judit
   Pereira, Sofia A.
TI Oxalate (dys)Metabolism: Person-to-Person Variability, Kidney and
   Cardiometabolic Toxicity
SO GENES
LA English
DT Review
DE cardiovascular disease; hyperoxaluria; hypertension; metabolic disease;
   microbiota; nephrolithiasis; kidney disease; kidney stones; obstructive
   sleep apnea; systemic inflammation; pharmacology
ID OBSTRUCTIVE SLEEP-APNEA; CHRONIC INTERMITTENT HYPOXIA; STRESS MEDIATED
   APOPTOSIS; DIETARY CALCIUM INTAKE; PRIMARY HYPEROXALURIA;
   OXALOBACTER-FORMIGENES; METABOLIC SYNDROME; RENAL-FAILURE; GLYOXYLATE
   AMINOTRANSFERASE; MITOCHONDRIAL DYSFUNCTION
AB Oxalate is a metabolic end-product whose systemic concentrations are highly variable among individuals. Genetic (primary hyperoxaluria) and non-genetic (e.g., diet, microbiota, renal and metabolic disease) reasons underlie elevated plasma concentrations and tissue accumulation of oxalate, which is toxic to the body. A classic example is the triad of primary hyperoxaluria, nephrolithiasis, and kidney injury. Lessons learned from this example suggest further investigation of other putative factors associated with oxalate dysmetabolism, namely the identification of precursors (glyoxylate, aromatic amino acids, glyoxal and vitamin C), the regulation of the endogenous pathways that produce oxalate, or the microbiota's contribution to oxalate systemic availability. The association between secondary nephrolithiasis and cardiovascular and metabolic diseases (hypertension, type 2 diabetes, and obesity) inspired the authors to perform this comprehensive review about oxalate dysmetabolism and its relation to cardiometabolic toxicity. This perspective may offer something substantial that helps advance understanding of effective management and draws attention to the novel class of treatments available in clinical practice.
C1 [Baltazar, Pedro; Fonseca, Nuno Moreira; Lanca, Miguel Brito; Campos Pinheiro, Luis; Calado, Joaquim] Ctr Hosp Univ Lisboa Cent, EPE, P-1150199 Lisbon, Portugal.
   [Baltazar, Pedro; de Melo Jr, Antonio Ferreira; Sequeira, Catarina O.; Teixeira-Santos, Luisa; Monteiro, Emilia C.; Campos Pinheiro, Luis; Sousa, Catia; Morello, Judit; Pereira, Sofia A.] Univ NOVA Lisboa, NOVA Med Sch, iNOVA4Hlth, Fac Ciencias Med,NMS FCM, P-1150082 Lisbon, Portugal.
   [Baltazar, Pedro; de Melo Jr, Antonio Ferreira; Fonseca, Nuno Moreira; Teixeira-Santos, Luisa; Monteiro, Emilia C.; Campos Pinheiro, Luis; Calado, Joaquim; Sousa, Catia; Pereira, Sofia A.] Ctr Clin Acad Lisboa, P-1159056 Lisbon, Portugal.
   [Faria, Ana] Univ NOVA Lisboa, NOVA Med Sch, CHRC, NMS FCM,Fac Ciencias Med, P-1150082 Lisbon, Portugal.
   [Calado, Joaquim] Univ NOVA Lisboa, NOVA Med Sch, ToxOmics, NMS FCM,Fac Ciencias Med, P-1150082 Lisbon, Portugal.
C3 Universidade Nova de Lisboa; Universidade Nova de Lisboa; Universidade
   Nova de Lisboa
RP Pereira, SA (corresponding author), Univ NOVA Lisboa, NOVA Med Sch, iNOVA4Hlth, Fac Ciencias Med,NMS FCM, P-1150082 Lisbon, Portugal.; Pereira, SA (corresponding author), Ctr Clin Acad Lisboa, P-1159056 Lisbon, Portugal.
EM pedrombaltazar@gmail.com; melo.junior@nms.unl.pt;
   nuno.moreira.fonseca@nyu.edu; miguellanca@campus.ul.pt;
   ana.faria@nms.unl.pt; catarina.sequeira@nms.unl.pt;
   luisa.santos@nms.unl.pt; emilia.monteiro@nms.unl.pt;
   luiscampospinheiro@gmail.com; jcalado@nms.unl.pt;
   catia.moreirasousa@nms.unl.pt; judit.morello@nms.unl.pt;
   sofia.pereira@nms.unl.pt
RI Moreira de Sousa, Cátia/ISA-8012-2023; Monteiro, Emilia/MCY-0960-2025;
   Ferreira de Melo Junior, Antonio/LIG-3474-2024; de Azeredo Pereira,
   Sofia/M-2976-2019; Teixeira-Santos, Luisa/IYS-6429-2023
OI Moreira de Sousa, Catia/0000-0002-9802-5657; Sevinate Pontes Brito
   Lanca, Miguel Maria/0000-0002-9801-849X; Moreira Fonseca,
   Nuno/0000-0003-0821-2764; Morello, Judit/0000-0002-1148-9329; de Azeredo
   Pereira, Sofia/0000-0002-8456-9995; Sequeira,
   Catarina/0000-0003-2003-3478; Ferreira de Melo Junior,
   Antonio/0000-0001-6831-1823; Teixeira-Santos, Luisa/0000-0001-7729-9010;
   Faria, Ana/0000-0002-5165-9513
FU Sofia de Azeredo Pereira is a member of the translational nephrology
   study group of the Portuguese Society of Nephrology.;
   Portuguese Society of Nephrology
FX Sofia de Azeredo Pereira is a member of the translational nephrology
   study group of the <ITALIC>Portuguese Society of Nephrology</ITALIC>.
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NR 231
TC 7
Z9 7
U1 1
U2 9
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2073-4425
J9 GENES-BASEL
JI Genes
PD SEP
PY 2023
VL 14
IS 9
AR 1719
DI 10.3390/genes14091719
PG 28
WC Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Genetics & Heredity
GA S6EA3
UT WOS:001072062500001
PM 37761859
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Khater, SI
   Shalabi, M
   Alammash, BB
   Alrais, AI
   Al-ahmadi, D
   Alqahtani, LS
   Khamis, T
   Abdelaziz, S
   Aldawy, K
AF Khater, Safaa I.
   Shalabi, Maram
   Alammash, Buthainah B.
   Alrais, Alaa I.
   Al-ahmadi, Doaa
   Alqahtani, Leena S.
   Khamis, Tarek
   Abdelaziz, Sahar
   Aldawy, Khalifa
TI Autophagy characteristics of phytoestrogens in management and prevention
   of diseases: A narrative review of in-vivo and
   in-vitro studies
SO JOURNAL OF ADVANCED VETERINARY AND ANIMAL RESEARCH
LA English
DT Review
DE AMP-activated protein kinase (AMPK); autophagy; cancer; coumestans;
   isoflavones; lignans; phytoestrogens; stilbenes
ID CELL APOPTOSIS; ER-ALPHA; GENISTEIN; DIFFERENTIATION; ENTEROLACTONE;
   ISOFLAVONES; RESVERATROL; METABOLITES; PATHWAYS; STRESS
AB Phytoestrogens are non-steroid polyphenolic materials present in 300 plants. Regarding their structural similarities to estradiol, phytoestrogens attach to estrogen receptors and display anti -or pro-estrogenic activities. This review explored phytoestrogens' potential advantages and auto-phagy properties in light of their future application for disease management, highlighting how phytoestrogens could modulate autophagy. Research has examined the prospective benefits of phytoestrogens for the anticipation and management of various conditions, including signs of menopause, tumors, skin deterioration, osteoporosis, heart disease, neurodegenerative con-ditions, disorders of the immune system, and metabolic syndrome, owing to their therapeutic effects. As phytoestrogens can activate or inhibit autophagy, which has antioxidant, apoptotic, anti-mutagenic, anticancer, transcriptional, and genomic impacts on cancer and aging illnesses, phytoestrogens could influence diseases through the modulation of autophagy. The collaborative research on animal models, utilization of genetic techniques, and administration of pharmacolog-ically active substances has indicated the possible therapeutic benefits of autophagy modulation in various illnesses. Further research is required to illustrate the pathways by which phytoestro-gens modulate autophagy and the possible therapeutic effects on these diseases.
C1 [Khater, Safaa I.; Shalabi, Maram; Aldawy, Khalifa] Zagazig Univ, Fac Vet Med, Dept Biochem, Zagazig, Egypt.
   [Alammash, Buthainah B.; Alrais, Alaa I.] King Fahad Hosp, Minist Hlth, Medina, Saudi Arabia.
   [Al-ahmadi, Doaa] Minist Hlth, Matern & Children Hosp MCH, Medina, Saudi Arabia.
   [Alqahtani, Leena S.] Univ Jeddah, Coll Sci, Dept Biochem, Jeddah 23445, Saudi Arabia.
   [Khamis, Tarek] Zagazig Univ, Fac Vet Med, Dept Pharmacol, Lab Biotechnol, Zagazig, Egypt.
   [Abdelaziz, Sahar] Zagazig Univ, Fac Pharm, Dept Pharmacognosy, Zagazig, Egypt.
C3 Egyptian Knowledge Bank (EKB); Zagazig University; University of Jeddah;
   Egyptian Knowledge Bank (EKB); Zagazig University; Egyptian Knowledge
   Bank (EKB); Zagazig University
RP Shalabi, M (corresponding author), Zagazig Univ, Fac Vet Med, Dept Biochem, Zagazig, Egypt.
EM roma.omda3372@gmail.com
RI saeed, leena/ABY-2113-2022; khamis, Tarek/AAD-4002-2021; Abdelaziz,
   Sahar/HHZ-9560-2022; khater, Safaa/ABB-8733-2020
OI Khamis, Tarek/0000-0003-4722-2666
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NR 127
TC 2
Z9 2
U1 5
U2 13
PU NETWORK VETERINARIANS BANGLADESH
PI MYMENSINGH
PA FAC VETERINARY SCIENCE, BANGLADESH AGRICULTURAL UNIV, MYMENSINGH, 2202,
   BANGLADESH
EI 2311-7710
J9 J ADV VET ANIM RES
JI J. Adv. Vet. Anim. Res.
PD JUN
PY 2023
VL 10
IS 2
BP 308
EP 320
DI 10.5455/javar.2023.j683
PG 13
WC Agriculture, Dairy & Animal Science; Veterinary Sciences
WE Emerging Sources Citation Index (ESCI)
SC Agriculture; Veterinary Sciences
GA N3CC9
UT WOS:001035824700005
PM 37534069
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Wang, XC
   Ding, SM
AF Wang, Xuechang
   Ding, Suming
TI The biological and pharmacological connections between diabetes and
   various types of cancer
SO PATHOLOGY RESEARCH AND PRACTICE
LA English
DT Review
DE Diabetes; Cancer; Biologic pathway; Insulin; Malignancy
ID RENAL-CELL CARCINOMA; BREAST-CANCER; COLORECTAL-CANCER;
   HEPATOCELLULAR-CARCINOMA; ENDOMETRIAL CANCER; PANCREATIC-CANCER;
   METABOLIC SYNDROME; MELLITUS TYPE-2; RISK-FACTORS; GLUCOSE
AB Diabetes and cancer incidence have risen tremendously over the years. Additionally, both cancer and diabetes share numerous risks, such as overweight, inactive lifestyles, older age, and smoking. Numerous methods have been suggested to connect obesity and diabetes to cancer advancements, such as increasing insulin/ Insulin-like growth factor I (IGF-1) signaling, lipid and glucose uptake and metabolism, shifts in the cytokine, chemokine, and adipokine profile also variations in the adipose tissue immediately adjacent to cancer spots. Diabetes has been found to have a complicated cancer-causing mechanism involving excessive reactive oxygen species (ROS) production, loss of critical macromolecules, chronic inflammation, and delayed repair, all of which contribute to carcinogenesis. Diabetes-associated epithelial-to-mesenchymal transition and endothelial-to-mesenchymal transition lead to the formation of cancer-associated fibroblasts in tumors by enabling tumor cells to extravasate via the endothelium and epithelium. This study aims to describe the correlation between diabetes and cancer, as well as summarize the molecular connections and shared pathways such as sex hormones, hyperglycemia, inflammation, insulin axis, metabolic symbiosis, and endoplasmic reticulum (ER) stress that exist between them.
C1 [Wang, Xuechang] Univ West England, Dept Appl Sci, Bristol BS16 1QY, Avon, England.
   [Ding, Suming] Jiujiang Maternal & Child Hlth Hosp, Dept Ophthalmol, Jiujiang 332000, Peoples R China.
C3 University of West England
RP Wang, XC (corresponding author), Univ West England, Dept Appl Sci, Bristol BS16 1QY, Avon, England.
EM wangxuechang1997@126.com
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NR 93
TC 12
Z9 13
U1 1
U2 6
PU ELSEVIER GMBH
PI MUNICH
PA HACKERBRUCKE 6, 80335 MUNICH, GERMANY
SN 0344-0338
EI 1618-0631
J9 PATHOL RES PRACT
JI Pathol. Res. Pract.
PD NOV
PY 2021
VL 227
AR 153641
DI 10.1016/j.prp.2021.153641
EA OCT 2021
PG 8
WC Pathology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pathology
GA WD6AY
UT WOS:000705022100001
PM 34619575
DA 2025-06-11
ER

PT S
AU Ford, ND
   Patel, SA
   Narayan, MV
AF Ford, Nicole D.
   Patel, Shivani A.
   Narayan, M. Venkat
BE Fielding, JE
TI Obesity in Low- and Middle-Income Countries: Burden, Drivers, and
   Emerging Challenges
SO ANNUAL REVIEW OF PUBLIC HEALTH, VOL 38
SE Annual Review of Public Health
LA English
DT Review; Book Chapter
DE overweight; noncommunicable disease; nutrition transition
ID BODY-MASS INDEX; DEPENDENT DIABETES-MELLITUS; IMPAIRED
   GLUCOSE-TOLERANCE; NUTRITION TRANSITION; PHYSICAL-ACTIVITY;
   EPIDEMIOLOGIC TRANSITION; SOCIOECONOMIC-STATUS; WAIST CIRCUMFERENCE;
   METABOLIC SYNDROME; GLYCEMIC INDEX
AB We have reviewed the distinctive features of excess weight, its causes, and related prevention and management efforts, as well as data gaps and recommendations for future research in low- and middle-income countries (LMICs). Obesity is rising in every region of the world, and no country has been successful at reversing the epidemic once it has begun. In LMICs, overweight is higher in women compared with men, in urban compared with rural settings, and in older compared with younger individuals; however, the urban-rural overweight differential is shrinking in many countries. Overweight occurs alongside persistent burdens of underweight in LMICs, especially in young women. Changes in the global diet and physical activity are among the hypothesized leading contributors to obesity. Emerging risk factors include environmental contaminants, chronic psychosocial stress, neuroendocrine dysregulation, and genetic/epigenetic mechanisms. Data on effective strategies to prevent the onset of obesity in LMICs or elsewhere are limited. Expanding the research in this area is a key priority and has important possibilities for reverse innovation that may also inform interventions in high-income countries.
C1 [Ford, Nicole D.; Narayan, M. Venkat] Emory Univ, Laney Grad Sch, Nutr & Hlth Sci Program, Atlanta, GA 30322 USA.
   [Patel, Shivani A.; Narayan, M. Venkat] Emory Univ, Rollins Sch Publ Hlth, Hubert Dept Global Hlth, Atlanta, GA 30322 USA.
C3 Emory University; Emory University; Rollins School Public Health
RP Ford, ND (corresponding author), Emory Univ, Laney Grad Sch, Nutr & Hlth Sci Program, Atlanta, GA 30322 USA.
EM ndionne@emory.edu; s.a.patel@emory.edu; knaraya@emory.edu
RI Narayan, K.M./J-9819-2012
OI Patel, Shivani/0000-0003-0082-5857; Ford, Nicole/0000-0002-6463-5094
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NR 164
TC 328
Z9 353
U1 6
U2 69
PU ANNUAL REVIEWS
PI PALO ALTO
PA 4139 EL CAMINO WAY, PO BOX 10139, PALO ALTO, CA 94303-0897 USA
SN 0163-7525
BN 978-0-8243-2738-5
J9 ANNU REV PUBL HEALTH
JI Annu. Rev. Public Health
PY 2017
VL 38
BP 145
EP 164
DI 10.1146/annurev-publhealth-031816-044604
PG 20
WC Public, Environmental & Occupational Health
WE Book Citation Index – Social Sciences & Humanities (BKCI-SSH); Book Citation Index – Science (BKCI-S); Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA BH9MX
UT WOS:000404166400008
PM 28068485
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Hamur, H
   Duman, H
   Demirtas, L
   Bakirci, EM
   Durakoglugil, ME
   Degirmenci, H
   Kalkan, K
   Yildirim, E
   Vuruskan, E
AF Hamur, Hikmet
   Duman, Hakan
   Demirtas, Levent
   Bakirci, Eftal Murat
   Durakoglugil, Murtaza Emre
   Degirmenci, Husnu
   Kalkan, Kamuran
   Yildirim, Erkan
   Vuruskan, Ertan
TI Total Bilirubin Levels Predict Subclinical Atherosclerosis in Patients
   With Prediabetes
SO ANGIOLOGY
LA English
DT Article
DE bilirubin; prediabetes; subclinical atherosclerosis; carotid
   intima-media thickness
ID INTIMA-MEDIA THICKNESS; HIGHER SERUM BILIRUBIN; TO-LYMPHOCYTE RATIO;
   ELEVATION MYOCARDIAL-INFARCTION; CARDIOVASCULAR-DISEASE RISK; IMPAIRED
   GLUCOSE-TOLERANCE; CORONARY-ARTERY-DISEASE; ISCHEMIC-HEART-DISEASE;
   METABOLIC SYNDROME; OXIDATIVE STRESS
AB Bilirubin may have important antiatherosclerotic effects. Prediabetes (PD), the intermediate stage before diabetes mellitus, is associated with increased cardiovascular morbidity and mortality. We evaluated the relationship between serum bilirubin levels and carotid intima-media thickness (cIMT), as a surrogate marker of subclinical atherosclerosis, in patients with PD. We enrolled 170 consecutive patients with PD. The patients underwent ultrasonography to evaluate cIMT. The patients were divided into groups according to cIMT values (<0.9 vs 0.9 mm). The patients with cIMT 0.9 mm had significantly higher diastolic blood pressure, neutrophil-lymphocyte ratio (NLR), and glycated hemoglobin values compared with patients having cIMT < 0.9 mm, whereas total and direct bilirubin values were significantly lower in this group. Multivariate regression analyses revealed NLR and total bilirubin as the independent predictors of subclinical atherosclerosis. The present study demonstrated that NLR and lower total bilirubin levels were independent predictors of subclinical atherosclerosis in patients with PD. Simple measures such as NRL and total bilirubin may provide predictive information regarding the risk of cardiovascular disease in patients with PD.
C1 [Hamur, Hikmet; Bakirci, Eftal Murat; Degirmenci, Husnu] Erzincan Univ, Dept Cardiol, Fac Med, TR-24000 Erzincan, Turkey.
   [Duman, Hakan; Durakoglugil, Murtaza Emre] Recep Tayyip Erdogan Univ, Dept Cardiol, Fac Med, Rize, Turkey.
   [Demirtas, Levent] Erzincan Univ, Dept Internal Med, Fac Med, Erzincan, Turkey.
   [Kalkan, Kamuran; Yildirim, Erkan] Training & Res Hosp, Dept Cardiol, Erzurum, Turkey.
   [Vuruskan, Ertan] Dr Ersin Arslan State Hosp, Dept Cardiol, Gaziantep, Turkey.
C3 Erzincan Binali Yildirim University; Recep Tayyip Erdogan University;
   Erzincan Binali Yildirim University; Erzurum Bolge Training & Research
   Hospital; Dr. Ersin Arslan Education & Research Hospital
RP Hamur, H (corresponding author), Erzincan Univ, Dept Cardiol, Fac Med, TR-24000 Erzincan, Turkey.
EM hikmethamur@hotmail.com
RI Yıldırım, Erkan/Q-9702-2019; Duman, Hakan/J-5668-2019; Kalkan,
   Kamuran/HKF-3108-2023; Vuruskan, Ertan/AAH-4425-2020; Durakoglugil,
   Emre/Q-3547-2019
OI Kalkan, Kamuran/0000-0001-6204-316X; Durakoglugil, Murtaza
   Emre/0000-0001-5268-4262; duman, hakan/0000-0002-1441-7320
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NR 63
TC 15
Z9 15
U1 0
U2 13
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0003-3197
EI 1940-1574
J9 ANGIOLOGY
JI Angiology
PD NOV
PY 2016
VL 67
IS 10
BP 909
EP 915
DI 10.1177/0003319716632394
PG 7
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA DZ7HX
UT WOS:000386036600005
PM 26921264
DA 2025-06-11
ER

PT J
AU Barceló, P
   Nicolau, C
   Gamundí, A
   Fiol, MA
   Tresguerres, JAF
   Akaârir, M
   Rial, RV
AF Barcelo, Pere
   Nicolau, Cristina
   Gamundi, Antoni
   Fiol, Maria A.
   Tresguerres, Jesus A. F.
   Akaarir, Mourad
   Rial, Ruben V.
TI Comparing the Behavioural Effects of Exogenous Growth Hormone and
   Melatonin in Young and Old Wistar Rats
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Article
ID MILD COGNITIVE IMPAIRMENT; NEURONAL SIGNAL-TRANSDUCTION;
   CENTRAL-NERVOUS-SYSTEM; BODY-COMPOSITION; FACTOR-I; METABOLIC SYNDROME;
   CIRCADIAN-RHYTHMS; OXIDATIVE STRESS; SPATIAL MEMORY; RADIAL-ARM
AB Growth hormone (GH) and melatonin are two hormones with quite different physiological effects. Curiously, their secretion shows parallel and severe age-related reductions. This has promoted many reports for studying the therapeutic supplementation of both hormones in an attempt to avoid or delay the physical, physiological, and psychological decay observed in aged humans and in experimental animals. Interestingly, the effects of the external administration of low doses of GH and of melatonin were surprisingly similar, as both hormones caused significant improvements in the functional capabilities of aged subjects. The present report aims at discerning the eventual difference between cognitive and motor effects of the two hormones when administered to young and aged Wistar rats. The effects were tested in the radial maze, a test highly sensitive to the age-related impairments in working memory and also in the rotarod test, for evaluating the motor coordination. The results showed that both hormones caused clear improvements in both tasks. However, while GH improved the cognitive capacity and, most importantly, the physical stamina, the effects of melatonin should be attributed to its antioxidant, anxiolytic, and neuroprotective properties.
C1 [Barcelo, Pere; Nicolau, Cristina; Gamundi, Antoni; Fiol, Maria A.; Akaarir, Mourad; Rial, Ruben V.] Univ Illes Balears, Inst Univ Ciencies Salut, Ctra Valldemossa,Km 7,5, Palma De Mallorca 07122, Spain.
   [Tresguerres, Jesus A. F.] Univ Madrid, Dept Physiol, Fac Med, Madrid, Spain.
C3 Universitat de les Illes Balears
RP Barceló, P (corresponding author), Univ Illes Balears, Inst Univ Ciencies Salut, Ctra Valldemossa,Km 7,5, Palma De Mallorca 07122, Spain.
EM pbarcelocaldentey@gmail.com
RI Gamundi, Antoni/L-2560-2015; Akaarir, Mourad/JQW-7374-2023;
   Fiol-deRoque, Maria/AAZ-5888-2020
OI Fiol-deRoque, Maria Antonia/0000-0001-8566-0929; Gamundi Gamundi,
   Antoni/0000-0002-0880-4658; nicolau llobera,
   m.cristina/0000-0001-5174-4323; Rial, Ruben V./0000-0002-9738-2716
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NR 160
TC 8
Z9 9
U1 0
U2 10
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PY 2016
VL 2016
AR 5863402
DI 10.1155/2016/5863402
PG 17
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA EF8FO
UT WOS:000390564600001
PM 28050228
OA Green Published, Green Submitted, hybrid
DA 2025-06-11
ER

PT J
AU Chirumbolo, S
AF Chirumbolo, Salvatore
TI Plant phytochemicals as new potential drugs for immune disorders and
   cancer therapy: really a promising path?
SO JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
LA English
DT Article
DE plant phytochemical; cancer prevention; flavonoid; dietary polyphenols;
   resveratrol; tea catechins
ID GREEN TEA CATECHINS; RED WINE; ANTIINFLAMMATORY AGENTS;
   CLINICAL-IMPLICATIONS; DIETARY POLYPHENOLS; METABOLIC SYNDROME; FRUIT
   POLYPHENOLS; NATURAL-PRODUCTS; PROSTATE-CANCER; SIRTUIN SYSTEM
AB Plant phytochemicals represent an exciting opportunity to maintain best health conditions through a balanced and properly administered daily nutrition or dietary supplement and have often been considered a good option for obtaining a few promising, expensive new drugs from plants. Several polyphenolic compounds, such as resveratrol, tea catechins and flavonoids, which are commonly found in vegetables, fruits and plant-derived juices or beverages, exert well-evidenced cardioprotective, neuroprotective, chemopreventive and anti-inflammatory properties, but, nevertheless, further clinical and epidemiological research is required. Most of these botanical byproducts are produced as noxious components by plants, in order to prevent pathogen colonization, insect-mediated damage and also to discourage animals from eating them. An evolutionary theory of stress adaptation would explain how these toxic substances from nature act as protective molecules. A future challenge to achieve a rather complete understanding of these chemical phenol derivatives for human health should deal with the complexity of cellular signalling networks, the epigenetic machinery endowment of the cell and the nonlinear relationship between dose and effectiveness. Copyright (c) 2012 Society of Chemical Industry
C1 Univ Verona, Dept Med, Sect Geriatry, I-37134 Verona, Italy.
C3 University of Verona
RP Chirumbolo, S (corresponding author), Univ Verona, Dept Med, Sect Geriatry, Policlin GB Rossi Piazzale AL Scuro 10, I-37134 Verona, Italy.
EM salvatore.chirumbolo@univr.it
RI Chirumbolo, Salvatore/AGF-1981-2022; Chirumbolo, Salvatore/L-6865-2016
OI Chirumbolo, Salvatore/0000-0003-1789-8307
CR [Anonymous], ALTERN MED REV
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NR 88
TC 36
Z9 39
U1 0
U2 30
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-5142
J9 J SCI FOOD AGR
JI J. Sci. Food Agric.
PD JUN
PY 2012
VL 92
IS 8
BP 1573
EP 1577
DI 10.1002/jsfa.5670
PG 5
WC Agriculture, Multidisciplinary; Chemistry, Applied; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture; Chemistry; Food Science & Technology
GA 928AD
UT WOS:000302951000001
PM 22473298
DA 2025-06-11
ER

PT J
AU Bokor, S
   Csölle, I
   Felso, R
   Vass, RA
   Funke, S
   Ertl, T
   Molnár, D
AF Bokor, Szilvia
   Csolle, Ildiko
   Felso, Regina
   Vass, Reka A.
   Funke, Simone
   Ertl, Tibor
   Molnar, Denes
TI Dietary nutrients during gestation cause obesity and related metabolic
   changes by altering DNA methylation in the offspring
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Review
DE obesity; metabolic syndrome; maternal; nutrition; epigenetic; DNA
   methylation
ID ONE-CARBON METABOLISM; LOW-PROTEIN DIET; HIGH-FAT-DIET; VITAMIN-D;
   GENE-EXPRESSION; BLOOD-PRESSURE; INSULIN-RESISTANCE; HIGH MULTIVITAMIN;
   BODY-COMPOSITION; MATERNAL DIET
AB Growing evidence shows that maternal nutrition from preconception until lactation has an important effect on the development of non-communicable diseases in the offspring. Biological responses to environmental stress during pregnancy, including undernutrition or overnutrition of various nutrients, are transmitted in part by DNA methylation. The aim of the present narrative review is to summarize literature data on altered DNA methylation patterns caused by maternal macronutrient or vitamin intake and its association with offspring's phenotype (obesity and related metabolic changes). With our literature search, we found evidence for the association between alterations in DNA methylation pattern of different genes caused by maternal under- or overnutrition of several nutrients (protein, fructose, fat, vitamin D, methyl-group donor nutrients) during 3 critical periods of programming (preconception, pregnancy, lactation) and the development of obesity or related metabolic changes (glucose, insulin, lipid, leptin, adiponectin levels, blood pressure, non-alcoholic fatty liver disease) in offspring. The review highlights that maternal consumption of several nutrients could individually affect the development of offspring's obesity and related metabolic changes via alterations in DNA methylation.
C1 [Bokor, Szilvia; Csolle, Ildiko; Felso, Regina; Molnar, Denes] Univ Pecs, Med Sch, Dept Paediat, Pecs, Hungary.
   [Bokor, Szilvia; Csolle, Ildiko; Felso, Regina; Vass, Reka A.; Funke, Simone; Ertl, Tibor; Molnar, Denes] Univ Pecs, Natl Lab Human Reprod, H-7622 Pecs, Hungary.
   [Csolle, Ildiko] Univ Pecs, Fac Hlth Sci, Doctoral Sch Hlth Sci, Pecs, Hungary.
   [Vass, Reka A.; Funke, Simone; Ertl, Tibor] Univ Pecs, Med Sch, Dept Obstet & Gynaecol, Pecs, Hungary.
   [Vass, Reka A.] Magyar Imre Hosp Ajka, Obstet & Gynecol, H-8400 Ajka, Hungary.
C3 University of Pecs; University of Pecs; University of Pecs; University
   of Pecs
RP Bokor, S (corresponding author), Univ Pecs, Med Sch, Dept Paediat, Pecs, Hungary.
EM bokor.szilvia@pte.hu
RI Molnár, Dénes/AAB-6820-2022
FU Recovery and Resilience Facility of the European Union within the
   framework of Program Szechenyi Plan Plus [RRF-2.3.1-21-2022-00012];
   National Research, Development and Innovation Fund of Hungary
   [TKP2021-EGA-10, TKP2021-EGA]
FX The author(s) declare financial support was received for the research,
   authorship, and/or publication of this article. Project no.
   RRF-2.3.1-21-2022-00012, titled National Laboratory on Human
   Reproduction has been implemented with the support provided by the
   Recovery and Resilience Facility of the European Union within the
   framework of Program Szechenyi Plan Plus. Project no. TKP2021-EGA-10"
   has been implemented with the support provided from the National
   Research, Development and Innovation Fund of Hungary, financed under the
   TKP2021-EGA" funding scheme.
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NR 97
TC 5
Z9 5
U1 2
U2 10
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD FEB 20
PY 2024
VL 15
AR 1287255
DI 10.3389/fendo.2024.1287255
PG 17
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA JY0H9
UT WOS:001176598100001
PM 38449848
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Sun, K
   Li, X
   Scherer, PE
AF Sun, Kai
   Li, Xin
   Scherer, Philipp E.
TI Extracellular Matrix (ECM) and Fibrosis in Adipose Tissue: Overview and
   Perspectives
SO COMPREHENSIVE PHYSIOLOGY
LA English
DT Article
ID DIET-INDUCED OBESITY; INSULIN-RESISTANCE; LYSYL OXIDASE; MAST-CELLS;
   T-CELLS; GENE-EXPRESSION; RHEUMATOID-ARTHRITIS; CHRONIC INFLAMMATION;
   TARGETED ACTIVATION; METABOLIC SYNDROME
AB Fibrosis in adipose tissue is a major driver of obesity-related metabolic dysregulation. It is char-acterized by an overaccumulation of extracellular matrix (ECM) during unhealthy expansion of adipose tissue in response to over nutrition. In obese adipose-depots, hypoxia stimulates multiple pro-fibrotic signaling pathways in different cell populations, thereby inducing the overproduction of the ECM components, including collagens, noncollagenous proteins, and additional enzymatic components of ECM synthesis. As a consequence, local fibrosis develops. The result of fibrosis -induced mechanical stress not only triggers cell necrosis and inflammation locally in adipose tissue but also leads to system-wide lipotoxicity and insulin resistance. A better understanding of the mechanisms underlying the obesity-induced fibrosis will help design therapeutic approaches to reduce or reverse the pathological changes associated with obese adipose tissue. Here, we aim to summarize the major advances in the field, which include newly identified fibrotic factors, cell populations that contribute to the fibrosis in adipose tissue, as well as novel mechanisms underlying the development of fibrosis. We further discuss the potential therapeutic strategies to target fibro-sis in adipose tissue for the treatment of obesity-linked metabolic diseases and cancer.
C1 [Sun, Kai; Li, Xin] Univ Texas Hlth Sci Ctr Houston, Inst Mol Med, Ctr Metab & Degenerat Dis, Houston, TX 77030 USA.
   [Scherer, Philipp E.] Univ Texas Southwestern Med Ctr Dallas, Touchstone Diabet Ctr, Dept Internal Med, Dallas, TX USA.
   [Scherer, Philipp E.] Univ Texas Southwestern Med Ctr Dallas, Dept Cell Biol, Dallas, TX USA.
C3 University of Texas System; University of Texas Health Science Center
   Houston; University of Texas System; University of Texas Southwestern
   Medical Center Dallas; University of Texas System; University of Texas
   Southwestern Medical Center Dallas
RP Sun, K (corresponding author), Univ Texas Hlth Sci Ctr Houston, Inst Mol Med, Ctr Metab & Degenerat Dis, Houston, TX 77030 USA.
EM Kai.sun@uth.tmc.edu
RI Scherer, Philipp/K-7819-2012
OI Sun, Kai/0000-0002-4778-4549
FU NIH/NIDDK [R01-DK109001, R56-DK124419, R01-DK129815, R01DK131537,
   R01-DK55758, R01-DK099110, RC2-DK118620, R01-DK127274, R01-DK131537];
   Welsh Foundation Scholar
FX The authors are grateful to colleagues at UTH and UTSW for the critical
   discussions during the preparation of the review. We would like to thank
   the funding supports from NIH/NIDDK (R01-DK109001, R56-DK124419, and
   R01-DK129815 to Kai Sun; R01DK131537, R01-DK55758,R01-DK099110,
   RC2-DK118620, R01-DK127274, and R01-DK131537 to Philipp E. Scherer) and
   the Welsh Foundation Scholar (for Kai Sun). We apologize for omission
   ofany relevant references due to page limitations
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NR 297
TC 46
Z9 47
U1 3
U2 17
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 2040-4603
J9 COMPR PHYSIOL
JI Compr. Physiol.
PD JAN
PY 2023
VL 13
IS 1
BP 4387
EP 4407
DI 10.1002/cphy.c220020
PG 21
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA F4ND7
UT WOS:000982122100007
PM 36715281
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Sharma, A
   Chawla, R
   Kaur, J
   Madaan, R
AF Sharma, Alok
   Chawla, Rakesh
   Kaur, Jasleen
   Madaan, Reecha
TI An Overview of Phytotherapy Used in the Management of Type II Diabetes
SO CURRENT DIABETES REVIEWS
LA English
DT Review
DE Diabetes; phytocompound; antioxidant; natural medicine; diabetes
   mellitus; hyperlipidemia; metabolic syndrome
ID OXIDATIVE STRESS; ANTIOXIDANT; BLOOD
AB Diabetes mellitus is related to unconstrained high blood sugar and linked with long-term impairment, dysfunction and failure of several organs. Since 1980, the global frequency of diabetes has almost doubled in the adult population. In very rare cases due to poor prevention and management programs, diabetes causes worsening of health and reduced lifespan of the world population, thus impacting on the world's economy. Supplements, however, help in the improvement of nutritional deficiencies. Phytotherapeutics has the advantage of being economical and easy to access with marginal side effects. So, it is a preferred candidate for the management of diabetes. Currently, a multitude of pharmaceuticals are used which are obtained from natural sources having medicinal properties. The mechanistic approaches are based on the regulation of insulin signaling pathways, translocation of GLUT-4 receptors and/or activation of PPAR gamma. These natural compounds include numerous flavonoids which help in preventing glucose absorption by preventing the absorption of alpha-amylase and alpha-glucosidase. But to validate the efficacy and safety profile of these compounds, detailed validatory clinical studies are required. This review majorly focuses on the mechanistic approaches of various naturally derived compounds relevant for the condition of Diabetes Mellitus.
C1 [Sharma, Alok] ISF Coll Pharm, Dept Pharmacognosy, Moga, Punjab, India.
   [Chawla, Rakesh] Baba Farid Univ Hlth Sci, Univ Inst Pharmaceuti Cal Sci & Res, Faridkot, Punjab, India.
   [Kaur, Jasleen] NIPER Kolkata, Dept Pharmacol & Toxicol, Kolkata 700054, India.
   [Madaan, Reecha] Chitkara Univ, Chitkara Coll Pharm, Rajpura, Punjab, India.
C3 ISF College of Pharmacy; National Institute of Pharmaceutical Education
   & Research, S.A.S. Nagar (Mohali); Chitkara University, Punjab
RP Sharma, A (corresponding author), ISF Coll Pharm, Dept Pharmacognosy, Moga, Punjab, India.
EM alokalok22@gmail.com
RI Madaan, Reecha/IQS-7196-2023
OI Chawla, Dr Rakesh/0000-0002-5090-6033
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PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
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EI 1875-6417
J9 CURR DIABETES REV
JI Curr. Diabetes Reviews
PY 2022
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WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
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DA 2025-06-11
ER

PT J
AU Angoff, R
   Mosarla, RC
   Tsao, CW
AF Angoff, Rebecca
   Mosarla, Ramya C.
   Tsao, Connie W.
TI Aortic Stiffness: Epidemiology, Risk Factors, and Relevant Biomarkers
SO FRONTIERS IN CARDIOVASCULAR MEDICINE
LA English
DT Review
DE aortic stiffness; pulse wave velocity; cardiovascular health; risk
   factors; biomarkers
ID PULSE-WAVE VELOCITY; INCREASED ARTERIAL STIFFNESS; BLOOD-PRESSURE
   VARIABILITY; CORONARY-HEART-DISEASE; C-REACTIVE PROTEIN; SERUM
   URIC-ACID; ANGIOTENSIN-ALDOSTERONE SYSTEM; DIETARY-SODIUM RESTRICTION;
   EXPERT CONSENSUS DOCUMENT; CARDIOVASCULAR RISK
AB Aortic stiffness (AoS) is a maladaptive response to hemodynamic stress and both modifiable and non-modifiable risk factors, and elevated AoS increases afterload for the heart. AoS is a non-invasive marker of cardiovascular health and metabolic dysfunction. Implementing AoS as a diagnostic tool is challenging as it increases with age and varies amongst races. AoS is associated with lifestyle factors such as alcohol and smoking, as well as hypertension and comorbid conditions including metabolic syndrome and its components. Multiple studies have investigated various biomarkers associated with increased AoS, and this area is of particular interest given that these markers can highlight pathophysiologic pathways and specific therapeutic targets in the future. These biomarkers include those involved in the inflammatory cascade, anti-aging genes, and the renin-angiotensin aldosterone system. In the future, targeting AoS rather than blood pressure itself may be the key to improving vascular health and outcomes. In this review, we will discuss the current understanding of AoS, measurement of AoS and the challenges in interpretation, associated biomarkers, and possible therapeutic avenues for modulation of AoS.
C1 [Angoff, Rebecca; Tsao, Connie W.] Beth Israel Deaconess Med Ctr, Dept Med, Cardiovasc Div, Boston, MA 02215 USA.
   [Mosarla, Ramya C.] New York Univ Langone Hlth, Dept Med, Div Cardiol, New York, NY USA.
C3 Harvard University; Harvard University Medical Affiliates; Beth Israel
   Deaconess Medical Center; New York University
RP Tsao, CW (corresponding author), Beth Israel Deaconess Med Ctr, Dept Med, Cardiovasc Div, Boston, MA 02215 USA.
EM ctsao1@bidmc.harvard.edu
OI Angoff, Rebecca/0000-0002-6120-837X
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NR 197
TC 38
Z9 38
U1 2
U2 6
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2297-055X
J9 FRONT CARDIOVASC MED
JI Front. Cardiovasc. Med.
PD NOV 8
PY 2021
VL 8
AR 709396
DI 10.3389/fcvm.2021.709396
PG 15
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA XA8GF
UT WOS:000720878300001
PM 34820427
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Zhang, X
   Lerman, LO
AF Zhang, Xin
   Lerman, Lilach O.
TI Obesity and renovascular disease
SO AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
LA English
DT Review
DE obesity; renal artery stenosis; renin-angiotensin-aldosterone system;
   microvasculature; adipocyte; insulin resistance
ID BODY-MASS INDEX; INITIATED METABOLIC SYNDROME; CHRONIC KIDNEY-DISEASE;
   INSULIN-RESISTANCE; ADIPOSE-TISSUE; INTRAABDOMINAL PRESSURE; OXIDATIVE
   STRESS; BLOOD-PRESSURE; RENAL-FUNCTION; WEIGHT-LOSS
AB Obesity remains a prominent public health concern. Obesity not only contributes greatly to cardiovascular events but has also been identified to initiate and affect the progression of preexisting chronic kidney disease. The prevalence of renal artery stenosis is growing world-wide, especially in the elderly population and in individuals with atherosclerotic risk factors such as obesity. Prolonged renovascular disease causes inflammation and microvascular remodeling within the post-stenotic kidney, which promote tissue scarring and may account for irreversible renal damage. Obesity has been shown to aggravate kidney damage via several pathways, including exacerbation of microvascular regression and renal cell injury mediated by adipocytes and insulin resistance, thereby worsening the structural and functional outcomes of the kidney in renovascular disease. Dietary modification and inhibition of the renin-angiotensin-aldosterone system have been shown to alleviate obesity-induced tissue injury and remodeling. Possibly, angiogenic factors may boost microvascular repair in the ischemic kidney in the obesity milieu. Novel therapeutic interventions targeting deleterious pathways that are activated by obesity and responsible for kidney damage need to be explored in future studies.
C1 [Zhang, Xin; Lerman, Lilach O.] Mayo Clin, Div Nephrol & Hypertens, Rochester, MN 55905 USA.
   [Lerman, Lilach O.] Mayo Clin, Div Cardiovasc Dis, Rochester, MN 55905 USA.
C3 Mayo Clinic; Mayo Clinic
RP Lerman, LO (corresponding author), Mayo Clin, Div Nephrol & Hypertens, 200 First St SW, Rochester, MN 55905 USA.
EM lerman.lilach@mayo.edu
RI Lerman, Lilach/M-4962-2017
FU National Institutes of Health [DK73608, DK100081, DK102325, HL123160,
   DK104273]; American Heart Association
FX This study was partly supported by National Institutes of Health Grants
   DK73608, DK100081, DK102325, HL123160, and DK104273, and the American
   Heart Association.
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NR 85
TC 22
Z9 23
U1 0
U2 8
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 1931-857X
EI 1522-1466
J9 AM J PHYSIOL-RENAL
JI Am. J. Physiol.-Renal Physiol.
PD AUG 15
PY 2015
VL 309
IS 4
BP F273
EP F279
DI 10.1152/ajprenal.00547.2014
PG 7
WC Physiology; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology; Urology & Nephrology
GA CP2UD
UT WOS:000359731800001
PM 26041447
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Kindernay, L
   Ferenczyová, K
   Farkasová, V
   Dul'ová, U
   Strapec, J
   Barteková, M
AF Kindernay, Lucia
   Ferenczyova, Kristina
   Farkasova, Veronika
   Dul'ova, Ulrika
   Strapec, Jakub
   Bartekova, Monika
TI Beneficial Effects of Polyphenol-Rich Food Oils in Cardiovascular Health
   and Disease
SO REVIEWS IN CARDIOVASCULAR MEDICINE
LA English
DT Review
DE food oils; polyphenols; cardiovascular disease; hypertension;
   atherosclerosis; heart hypertrophy; cardioprotection
ID VIRGIN COCONUT OIL; ALPHA-LINOLENIC ACID; IMPROVES ENDOTHELIAL
   DYSFUNCTION; POLYUNSATURATED FATTY-ACIDS; INDUCED METABOLIC SYNDROME;
   DECREASE BLOOD-PRESSURE; P-COUMARIC ACID; OLIVE OIL; OXIDATIVE STRESS;
   SESAME OIL
AB A variety of vegetable and fruit derived food oils are considered beneficial for human health due to their content of functional components including their positive effects in cardiovascular system. In addition to the favorable ratio of unsaturated versus saturated fatty acids, some of these oils include also other health beneficial compounds such as vitamins, minerals, pigments, enzymes and phenolic compounds. Particularly polyphenols have been documented to exert numerous positive effects in cardiovascular system including their anti-hypertensive, anti-atherogenic as well as cardio- and vasculo- protective effects in subjects suffering from various cardiovascular and cardiometabolic diseases, likely via their antioxidant, anti-inflammatory, anti-coagulant, anti-proliferative and anti-diabetic properties. However, it has not been proven so far whether the positive cardiovascular effects of polyphenol-rich food oils are, and to what measure, attributed to their phenolic content. Thus, the current review aims to summarize the main cardiovascular effects of major polyphenolrich food oils including olive, flaxseed, soybean, sesame and coconut oils, and to uncover the role of their phenolic compounds in these effects.
C1 [Kindernay, Lucia; Ferenczyova, Kristina; Farkasova, Veronika; Dul'ova, Ulrika; Strapec, Jakub; Bartekova, Monika] Slovak Acad Sci, Inst Heart Res, Ctr Expt Med, Bratislava 84104, Slovakia.
   [Bartekova, Monika] Comenius Univ, Inst Physiol, Fac Med, Bratislava 81372, Slovakia.
C3 Slovak Academy of Sciences; Institute for Heart Research, SAS; Centre of
   Experimental Medicine, SAS; Slovak Academy of Sciences; Comenius
   University Bratislava
RP Barteková, M (corresponding author), Slovak Acad Sci, Inst Heart Res, Ctr Expt Med, Bratislava 84104, Slovakia.; Barteková, M (corresponding author), Comenius Univ, Inst Physiol, Fac Med, Bratislava 81372, Slovakia.
RI Farkašová, Veronika/IYS-6801-2023; Bartekova, Monika/GSI-4927-2022
OI Ferenczyova, Kristina/0000-0001-9950-6287; Farkasova,
   Veronika/0000-0003-2563-6382
FU Slovak Research and Development Agency; Scientific Grant Agency of the
   Ministry of Education, Science, Research and Sport of the Slovak
   Republic; Slovak Academy of Sciences VEGA [APVV-21-0194]; Stefan Schwarz
   Support Fund of the Slovak Academy of Sciences;  [2/0104/20]
FX This work was supported by the Slovak Research and Development Agency
   under the Contract no. APVV-21-0194 and by the grant from the Scientific
   Grant Agency of the Ministry of Education, Science, Research and Sport
   of the Slovak Republic and the Slovak Academy of Sciences VEGA no.
   2/0104/20. K.F. was supported from the Stefan Schwarz Support Fund of
   the Slovak Academy of Sciences.
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NR 238
TC 3
Z9 4
U1 5
U2 27
PU IMR PRESS
PI ROBINSON
PA 112 ROBINSON RD, ROBINSON, SINGAPORE
SN 1530-6550
EI 2153-8174
J9 REV CARDIOVASC MED
JI Rev. Cardiovasc. Med.
PD JUL
PY 2023
VL 24
IS 7
DI 10.31083/j.rcm2407190
PG 25
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA O5XH3
UT WOS:001044530900014
PM 39077008
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Rahman, MS
   Pang, WK
   Amjad, S
   Ryu, D
   Adegoke, EO
   Park, YJ
   Pang, MG
AF Rahman, Md Saidur
   Pang, Won-Ki
   Amjad, Shehreen
   Ryu, Do-Yeal
   Adegoke, Elikanah Olusayo
   Park, Yoo-Jin
   Pang, Myung-Geol
TI Hepatic consequences of a mixture of endocrine-disrupting chemicals in
   male mice
SO JOURNAL OF HAZARDOUS MATERIALS
LA English
DT Article
DE EDCs; BPA; Phthalates; Apoptosis; Steatohepatitis; Metabolism; Fibrosis
ID BISPHENOL-A; HEPATOCYTE APOPTOSIS; PERINATAL EXPOSURE; LIVER FIBROSIS;
   ESTROGEN; ACTIVATION; EXPRESSION; ASSOCIATION; INFLAMMATION; MECHANISM
AB The global epidemic of metabolic syndrome has been partially linked to ubiquitous exposure to endocrine disrupting chemicals (EDCs). Although the impacts of exposure to single EDCs have been thoroughly studied, the consequences of simultaneous uncontrolled exposure to multiple EDCs require further investigations. Therefore, in this study, we evaluated how exposure to mixtures containing bisphenol A and seven phthalates impacts liver functions and metabolic homeostasis. Male mice were gavaged with either EDCs at four different dose combinations or corn oil (control) for six weeks. The results showed that exposure to EDCs at the human daily exposure limit had a negligible impact on liver function. However, EDC at > 25 orders of magnitude of human-relevant doses had detrimental impacts on overall liver function, leading to metabolic abnormalities, steatohepatitis, and hepatic fibrosis via the activation of both genomic and non-genomic pathways. The metabolic phenotype was linked to alterations in key genes involved in hepatic lipid and glucose metabolism. In contrast, alterations in cytokine expression, oxidative stress, and apoptosis impacted steatohepatitis and fibrosis. Because EDC exposure does not occur independently, the findings of the combined effects of exposure to multiple EDCs have significant relevance for public health.
C1 [Pang, Myung-Geol] Chung Ang Univ, Dept Anim Sci & Technol, Anseong 17546, South Korea.
   Chung Ang Univ, BET Res Inst, Anseong 17546, South Korea.
C3 Chung Ang University; Chung Ang University
RP Pang, MG (corresponding author), Chung Ang Univ, Dept Anim Sci & Technol, Anseong 17546, South Korea.
EM mgpang@cau.ac.kr
RI Adegoke, Elikanah, Olusayo/AAW-1771-2020; amjad, shehreen/GQI-4250-2022;
   PARK, YOOJIN/KHY-7818-2024; Rahman, Md Saidur/AAT-2972-2020; Pang,
   Myung-Geol/AAV-2014-2021
OI Amjad, Shehreen/0000-0003-1618-0213; Pang,
   Myung-Geol/0000-0003-2019-3789
FU Basic Science Research Program through the National Research Foundation
   of Korea (NRF) - Ministry of Education [NRF-2018R1A6A1A03025159]
FX Funding This research was supported by the Basic Science Research
   Program through the National Research Foundation of Korea (NRF) funded
   by the Ministry of Education (NRF-2018R1A6A1A03025159) .
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NR 76
TC 15
Z9 16
U1 2
U2 41
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0304-3894
EI 1873-3336
J9 J HAZARD MATER
JI J. Hazard. Mater.
PD AUG 15
PY 2022
VL 436
AR 129236
DI 10.1016/j.jhazmat.2022.129236
EA MAY 2022
PG 13
WC Engineering, Environmental; Environmental Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering; Environmental Sciences & Ecology
GA 1X2WO
UT WOS:000807320400002
PM 35739755
DA 2025-06-11
ER

PT J
AU Rodriguez-Nunez, I
   Caluag, T
   Kirby, K
   Rudick, CN
   Dziarski, R
   Gupta, D
AF Rodriguez-Nunez, Ivan
   Caluag, Tiffany
   Kirby, Kori
   Rudick, Charles N.
   Dziarski, Roman
   Gupta, Dipika
TI Nod2 and Nod2-regulated microbiota protect BALB/c mice from diet-induced
   obesity and metabolic dysfunction
SO SCIENTIFIC REPORTS
LA English
DT Article
ID GUT MICROBIOTA; ADIPOSE-TISSUE; INDUCED INFLAMMATION;
   INSULIN-RESISTANCE; PEPTIDOGLYCAN; FAT; RECOGNITION; SUSCEPTIBILITY;
   ACCUMULATION; ASSOCIATION
AB Genetics plays a central role in susceptibility to obesity and metabolic diseases. BALB/c mice are known to be resistant to high fat diet ( HFD)- induced obesity, however the genetic cause remains unknown. We report that deletion of the innate immunity antibacterial gene Nod2 abolishes this resistance, as Nod2-/-BALB/c mice developed HFD-dependent obesity and hallmark features of metabolic syndrome. Nod2-/-HFD mice developed hyperlipidemia, hyperglycemia, glucose intolerance, increased adiposity, and steatosis, with large lipid droplets in their hepatocytes. These changes were accompanied by increased expression of immune genes in adipose tissue and differential expression of genes for lipid metabolism, signaling, stress, transport, cell cycle, and development in both adipose tissue and liver. Nod2-/-HFD mice exhibited changes in the composition of the gut microbiota and long-term treatment with antibiotics abolished diet- dependent weight gain in Nod2-/-mice, but not in wild type mice. Furthermore, microbiota from Nod2-/-HFD mice transferred sensitivity to weight gain, steatosis, and hyperglycemia to wild type germ free mice. In summary, we have identified a novel role for Nod2 in obesity and demonstrate that Nod2 and Nod2-regulated microbiota protect BALB/c mice from dietinduced obesity and metabolic dysfunction.
C1 [Rodriguez-Nunez, Ivan; Caluag, Tiffany; Kirby, Kori; Rudick, Charles N.; Dziarski, Roman; Gupta, Dipika] Indiana Univ Sch Med Northwest, Gary, IN 46408 USA.
RP Gupta, D (corresponding author), Indiana Univ Sch Med Northwest, Gary, IN 46408 USA.
EM dgupta@iun.edu
FU DoD Discovery [PR141819]
FX Acknowledgements We are grateful to Gabriel Nunez for the original
   Nod2-/-BALB/c mice, Julie Cook for maintaining and breeding our mice,
   and Tatiana Kostrominova for guidance with the histology protocol and
   for the use of the wheel activity equipment. This work was supported in
   part by the DoD Discovery Award PR141819 to D.G.
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NR 69
TC 43
Z9 45
U1 0
U2 12
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD APR 3
PY 2017
VL 7
AR 548
DI 10.1038/s41598-017-00484-2
PG 18
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA EQ5PM
UT WOS:000398135100004
PM 28373658
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Sarikurkcu, C
   Uren, MC
   Tepe, B
   Cengiz, M
   Kocak, MS
AF Sarikurkcu, Cengiz
   Uren, Mehmet Cemil
   Tepe, Bektas
   Cengiz, Mustafa
   Kocak, Mehmet Sefa
TI Phlomis armeniaca: Phenolic compounds, enzyme inhibitory and
   antioxidant activities
SO INDUSTRIAL CROPS AND PRODUCTS
LA English
DT Article
DE Phlomis armeniaca; Antioxidant; Enzyme inhibitory; Phenolic content;
   HPLC
ID METABOLIC SYNDROME; ESSENTIAL OILS; HERBAL TEAS; IN-VITRO; L.; EXTRACTS;
   ALZHEIMER; ANISODONTA; RELEVANT; DISEASE
AB This study investigated the phenolic content, enzyme-inhibitory and antioxidant activities of ethyl acetate, methanol and water extracts of Phlomis armeniaca. HPLC analysis showed chlorogenic acid to be the most abundant phytochemical, followed by benzoic acid. Phosphomolybdenum and beta-carotene bleaching tests indicated the ethyl acetate extract to have the best activity potential (1.80 mmol trolox equivalents TEs/g extract and 91.50%, respectively); however, the water extract performed best in 1,1-diphenyl-2-picrylhydrazyl (DPPH) and superoxide anion radical scavenging tests (125.23 and 43.05 mg TEs/g extract, respectively). Chelating effects and reducing powers of the extracts were also determined. Ethyl acetate extract exhibited considerable enzyme inhibition potential on acetylcholinesterase, butyrylcholinesterase, tyrosinase, alpha-glucosidase and alpha-amylase (2.065 mg galantamine equivalents GALAEs/g extract, 4.579 mg GALAEs/g extract, 15.97 mg kojic acid equivalents/g extract, 0.474 mmol acarbose equivalents ACEsig extract and 2.261 mmol ACEs/g extract, respectively). These findings suggest that P. armeniaca may be useful in the development of an alternative agent for oxidative stress, Alzheimer's disease and diabetes. (C) 2015 Elsevier B.V. All rights reserved.
C1 [Sarikurkcu, Cengiz] Suleyman Demirel Univ, Dept Analyt Chem, Fac Pharm, TR-32200 Isparta, Turkey.
   [Uren, Mehmet Cemil; Kocak, Mehmet Sefa] Suleyman Demirel Univ, Atabey Vocat Sch, Dept Med & Aromat Plants, TR-32200 Isparta, Turkey.
   [Tepe, Bektas] Kilis 7 Aralik Univ, Fac Sci & Literature, Dept Mol Biol & Genet, Kilis, Turkey.
   [Cengiz, Mustafa] Suleyman Demirel Univ, Dept Chem, Fac Sci & Literature, TR-32200 Isparta, Turkey.
C3 Suleyman Demirel University; Suleyman Demirel University; Kilis 7 Aralik
   University; Suleyman Demirel University
RP Tepe, B (corresponding author), Kilis 7 Aralik Univ, Fac Sci & Literature, Dept Mol Biol & Genet, Kilis, Turkey.
EM bektastepe@yahoo.com
RI Sarikurkcu, Cengiz/H-8386-2018; TEPE, Bektas/GZM-5592-2022; TEPE,
   Bektas/N-2987-2013
OI Sarikurkcu, Cengiz/0000-0001-5094-2520; TEPE, Bektas/0000-0001-8982-5188
FU Scientific Research Commission of Suleyman Demirel University,
   Isparta-TURKEY [4071-D2-14]
FX Data concerning Phlomis armeniaca presented here are basically
   originated from Mr. Mehmet Cemil UREN's PhD thesis. The authors would
   like to thank to the Scientific Research Commission of Suleyman Demirel
   University, Isparta-TURKEY for its financial support (Project Number:
   4071-D2-14).
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NR 34
TC 30
Z9 32
U1 0
U2 68
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0926-6690
EI 1872-633X
J9 IND CROP PROD
JI Ind. Crop. Prod.
PD DEC 30
PY 2015
VL 78
BP 95
EP 101
DI 10.1016/j.indcrop.2015.10.016
PG 7
WC Agricultural Engineering; Agronomy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture
GA CZ0FI
UT WOS:000366780100013
DA 2025-06-11
ER

PT J
AU Ulhôa, MA
   Marqueze, EC
   Burgos, LGA
   Moreno, CRC
AF Ulhoa, M. A.
   Marqueze, E. C.
   Burgos, L. G. A.
   Moreno, C. R. C.
TI Shift Work and Endocrine Disorders
SO INTERNATIONAL JOURNAL OF ENDOCRINOLOGY
LA English
DT Review
ID BODY-MASS INDEX; PERIPHERAL CIRCADIAN OSCILLATORS; METABOLIC SYNDROME;
   DIABETES-MELLITUS; CORTISOL RESPONSE; PHYSICAL-ACTIVITY;
   GENE-EXPRESSION; HEART-DISEASE; RISK-FACTORS; SHORT-SLEEP
AB The objective of this review was to investigate the impact of shift and night work on metabolic processes and the role of alterations in the sleep-wake cycle and feeding times and environmental changes in the occurrence of metabolic disorders. The literature review was performed by searching three electronic databases for relevant studies published in the last 10 years. The methodological quality of each study was assessed, and best-evidence synthesis was applied to draw conclusions. The literature has shown changes in concentrations of melatonin, cortisol, ghrelin, and leptin among shift workers. Melatonin has been implicated for its role in the synthesis and action of insulin. The action of this hormone also regulates the expression of transporter glucose type 4 or triggers phosphorylation of the insulin receptor. Therefore, a reduction in melatonin can be associated with an increase in insulin resistance and a propensity for the development of diabetes. Moreover, shift work can negatively affect sleep and contribute to sedentarism, unhealthy eating habits, and stress. Recent studies on metabolic processes have increasingly revealed their complexity. Physiological changes induced in workers who invert their activity-rest cycle to fulfill work hours include disruptions in metabolic processes.
C1 [Ulhoa, M. A.] UNEC, Dept Med, BR-35300345 Caratinga, MG, Brazil.
   [Ulhoa, M. A.] IMES, Ipatinga, MG, Brazil.
   [Marqueze, E. C.] Univ Catolica Santos, Grad Program Publ Hlth, Dept Epidemiol, BR-11015002 Santos, SP, Brazil.
   [Burgos, L. G. A.; Moreno, C. R. C.] Univ Sao Paulo, Sch Publ Hlth, Dept Environm Hlth, BR-01246904 Sao Paulo, SP, Brazil.
   [Moreno, C. R. C.] Stockholm Univ, Stress Res Inst, S-10691 Stockholm, Sweden.
C3 Universidade Catolica de Santos; Universidade de Sao Paulo; Stockholm
   University
RP Ulhôa, MA (corresponding author), UNEC, Dept Med, Unity 2, BR-35300345 Caratinga, MG, Brazil.
EM meulhoa@usp.br
RI Marqueze, Elaine Cristina/V-3077-2019; Marqueze, Elaine/I-7629-2013;
   Moreno, Claudia Roberta/I-3298-2012
OI Marqueze, Elaine/0000-0002-4987-7757; Moreno, Claudia
   Roberta/0000-0003-1839-9673
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NR 75
TC 74
Z9 81
U1 0
U2 40
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1687-8337
EI 1687-8345
J9 INT J ENDOCRINOL
JI Int. J. Endocrinol.
PY 2015
VL 2015
AR 826249
DI 10.1155/2015/826249
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA CF9WE
UT WOS:000352917100001
PM 25892993
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Peng, CH
   Yang, YS
   Chan, KC
   Wang, CJ
   Chen, ML
   Huang, CN
AF Peng, Chiung-Huei
   Yang, Yi-Sun
   Chan, Kuei-Chuan
   Wang, Chau-Jong
   Chen, Mu-Lin
   Huang, Chien-Ning
TI Hibiscus sabdariffa Polyphenols Alleviate Insulin Resistance and
   Renal Epithelial to Mesenchymal Transition: A Novel Action Mechanism
   Mediated by Type 4 Dipeptidyl Peptidase
SO JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
LA English
DT Article
DE diabetic nephropathy; epithelial to mesenchymal transition; insulin
   resistance; polyphenol extracts of Hibiscus sabdariffa; type 4
   dipeptidyl peptidase
ID DIABETIC-NEPHROPATHY; OXIDATIVE STRESS; METABOLIC SYNDROME; CAFFEIC
   ACID; RECEPTOR; PHOSPHORYLATION; KIDNEY; MICE; DYSFUNCTION; PROGRESSION
AB The epithelial to mesenchymal transition (EMT) is important in renal fibrosis . Ser307 phosphorylation of insulin receptor substrate-1 (IRS-1 (S307)) is a hallmark of insulin resistance. We report that polyphenol extracts of Hibiscus sabdariffa (HPE) ameliorate diabetic nephropathy and EMT. Recently it has been observed that type 4-dipeptidyl peptidase (DPP-4) inhibitor linagliptin is effective for treating type 2 diabetes and albuminuria. We investigated if DPP-4 and insulin resistance are involved in renal EMT and explored the role of HPE. In high glucose-stimulated tubular cells, HPE, like lingaliptin, inhibited DPP-4 activation, thereby regulating vimentin (EMT marker) and IRS-1 (S307). IRS 1 knockdown revealed its essential role in mediating downstream EMT. In type 2 diabetic rats, pIRS-1 (S307) abundantly surronds the tubular region, with increased vimentn in kidney. Both the expression were reduced by HPE. In conclusion, HPE exerts effects similar to those of linagliptin, which improves insulin resistance and EMT, and could be an adjuvant to prevent diabetic nephropathy.
C1 [Peng, Chiung-Huei] Hungkuang Univ, Div Basic Med Sci, Taichung 43302, Taiwan.
   [Yang, Yi-Sun; Chan, Kuei-Chuan; Huang, Chien-Ning] Chung Shan Med Univ Hosp, Dept Internal Med, Taichung 402, Taiwan.
   [Yang, Yi-Sun; Huang, Chien-Ning] Chung Shan Med Univ, Inst Med, Taichung 402, Taiwan.
   [Chan, Kuei-Chuan] Chung Shan Med Univ, Sch Med, Taichung 402, Taiwan.
   [Wang, Chau-Jong; Chen, Mu-Lin] Chung Shan Med Univ, Inst Biochem & Biotechnol, Taichung 402, Taiwan.
C3 Hungkuang University; Chung Shan Medical University; Chung Shan Medical
   University Hospital; Chung Shan Medical University; Chung Shan Medical
   University; Chung Shan Medical University
RP Huang, CN (corresponding author), Chung Shan Med Univ, Inst Med, 110,Sect 1,Chien Kuo North Rd, Taichung 402, Taiwan.
EM cshy049@csh.org.tw
RI 陈, 文杰·/HHN-5495-2022
FU Chung-Shan Medical University Hospital [CSH-2014-0006]; National Science
   Council, Taiwan, under MOST [103-2320-B-241-002]
FX Funding for this research was provided by Chung-Shan Medical University
   Hospital, under CSH-2014-0006, and National Science Council, Taiwan,
   under MOST 103-2320-B-241-002.
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NR 39
TC 18
Z9 18
U1 0
U2 14
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0021-8561
EI 1520-5118
J9 J AGR FOOD CHEM
JI J. Agric. Food Chem.
PD OCT 8
PY 2014
VL 62
IS 40
BP 9736
EP 9743
DI 10.1021/jf5024092
PG 8
WC Agriculture, Multidisciplinary; Chemistry, Applied; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture; Chemistry; Food Science & Technology
GA AQ7RF
UT WOS:000343016200015
PM 25226384
DA 2025-06-11
ER

PT J
AU Rosa, FT
   Zulet, MA
   Marchini, JS
   Martínez, JA
AF Rosa, Flavia Troncon
   Angeles Zulet, M.
   Marchini, Julio Sergio
   Alfredo Martinez, J.
TI Bioactive compounds with effects on inflammation markers in humans
SO INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION
LA English
DT Article
DE inflammation; bioactive compounds; functional foods; polyphenols;
   bioactive peptides; review
ID NF-KAPPA-B; C-REACTIVE PROTEIN; L-CARNITINE SUPPLEMENT;
   CARDIOVASCULAR-DISEASE RISK; BLOOD MONONUCLEAR-CELLS; ESTROGEN PLUS
   PROGESTIN; CORONARY-HEART-DISEASE; NECROSIS-FACTOR-ALPHA; OXIDATIVE
   STRESS; LIPOIC ACID
AB Obesity and other chronic diseases are accompanied by adipose tissue, liver, pancreas, muscle and brain low-grade chronic inflammation. Indeed, the obese condition and metabolic syndrome are characterized by an increased expression of inflammatory cytokines and infiltration of immune cells in adipocytes. The inflammatory response promotes the activation of transcriptional factors and pro-inflammatory cytokines, which can lead to an unresolved inflammatory response associated with an inhibition of insulin signalling and high risk for cardiovascular events. Epidemiological and intervention studies have been carried out to find out dietary patterns, foods and bioactive compounds with protective anti-inflammatory actions. The most studied compounds are polyphenols, especially isoflavone and anthocyanin, but quercertin, catechin and resveratrol have also been investigated. Furthermore, some studies have reported the effects of milk peptides, plant sterol and stanol, L-carnitine and alpha-lipoic acid on inflammatory processes. This review aimed to collect and discuss those relevant studies reported in the scientific literature following a systematic scientific search about the effect of such bioactive compounds on inflammation in humans.
C1 [Rosa, Flavia Troncon; Marchini, Julio Sergio] Univ Sao Paulo, Div Clin Nutr, Dept Internal Med, Fac Med Ribeirao Preto, Sao Paulo, Brazil.
   [Angeles Zulet, M.; Alfredo Martinez, J.] Univ Navarra, Dept Nutr & Food Sci Physiol & Toxicol, E-31080 Pamplona, Spain.
C3 Universidade de Sao Paulo; University of Navarra
RP Martínez, JA (corresponding author), Univ Navarra, Dept Nutr & Food Sci, Edificio Invest,Calle Irunlarrea 1, Navarra 31008, Spain.
EM jalfmtz@unav.es
RI Rosa, Flávia/D-5263-2013; Zulet, M. Angeles/H-1317-2017; Marchini, Julio
   Sergio/K-1992-2016; Martinez Hernandez, J Alfredo/K-8709-2014
OI Zulet, M. Angeles/0000-0002-3926-0892; Marchini, Julio
   Sergio/0000-0001-9999-9149; Martinez Hernandez, J
   Alfredo/0000-0001-5218-6941
FU CAPES Foundation of the Ministry of Education of the Government of
   Brazil; Carolina Foundation, Spain; Linea Especial/97 of the University
   of Navarra; CIBER network of the Ministry of Health and Consumption of
   the Government of Spain; RETICS (PREDIMED) network of the Ministry of
   Health and Consumption of the Government of Spain
FX Thanks are given to CAPES Foundation of the Ministry of Education of the
   Government of Brazil and to Carolina Foundation, Spain, which provided a
   financial support to Rosa FT and also to the Linea Especial/97 of the
   University of Navarra and to CIBER and RETICS (PREDIMED) networks of the
   Ministry of Health and Consumption of the Government of Spain. The
   authors report no conflict of interest. The authors alone are
   responsible for the content and writing of the paper.
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NR 134
TC 42
Z9 46
U1 0
U2 72
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0963-7486
EI 1465-3478
J9 INT J FOOD SCI NUTR
JI Int. J. Food Sci. Nutr.
PD SEP
PY 2012
VL 63
IS 6
BP 749
EP 765
DI 10.3109/09637486.2011.649250
PG 17
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA 993HE
UT WOS:000307847400018
PM 22248031
DA 2025-06-11
ER

PT J
AU Hill, EE
   Eisenmann, JC
   Holmes, ME
   Heelan, KA
AF Hill, Emily E.
   Eisenmann, Joey C.
   Holmes, Megan E.
   Heelan, Kate A.
TI Morning Cortisol is Not Associated with Truncal Fatness or Resting Blood
   Pressure in Children: Cross-Sectional and 1-2 Year Follow-Up Analyses
SO JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
LA English
DT Article
ID ADRENAL AXIS ACTIVITY; METABOLIC SYNDROME; BODY-COMPOSITION; OBESITY;
   HYPERTENSION; STRESS; FAT; ADOLESCENTS; OVERWEIGHT; ADIPOSITY
AB Objective To evaluate the cross-sectional and longitudinal relationships of morning cortisol with trunk fat and resting blood pressure (BP) in children
   Methods Participants included 72 children aged 4-10 years (mean 7 4 yrs) for the cross-sectional analysis and 58 for the longitudinal analysis Height, weight, waist circumference, body fat by dual x-ray absorptiometry, and resting BP measures were obtained during a laboratory visit Saliva samples were collected at home on a single morning and assayed for cortisol
   Results Approximately 21% were overweight (15 3%) or obese (5 6%) Mean morning cortisol was 0 25 +/- 0 12 mu g/dL (6 99 +/- 3 46 nmol/L) There were no significant correlations between morning cortisol and any of the measures of fatness (r<-0 17) or BP (r<-0 10) at baseline Cortisol at baseline was not associated with changes in body size parameters after the 1- and 2- year follow-up period
   Conclusion Morning cortisol was not associated with body fatness or BP Future studies should examine the associations between the diurnal cortisol patterns, trunk fat, and BP by collecting samples throughout an entire day
C1 [Hill, Emily E.; Eisenmann, Joey C.; Holmes, Megan E.] Michigan State Univ, Dept Kinesiol, Ctr Phys Activ & Hlth, E Lansing, MI 48824 USA.
   [Heelan, Kate A.] Univ Nebraska, Human Performance Lab, Dept Hlth & Human Performance, Kearney, NE USA.
C3 Michigan State University; University of Nebraska System; University
   Nebraska Kearney
RP Eisenmann, JC (corresponding author), Michigan State Univ, Dept Kinesiol, Ctr Phys Activ & Hlth, E Lansing, MI 48824 USA.
OI Holmes, Megan/0000-0003-1716-6122
FU American Heart Association [665500Z]
FX This work was partially supported by the American Heart Association
   (#665500Z) We thank Bryce Abbey for his assistance in coordinating data
   collection and the numerous research assistants who assisted with data
   collection We also acknowledge the technical assistance of Dr Gregory
   Brown for conducting the cortisol assays
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NR 34
TC 8
Z9 9
U1 0
U2 4
PU WALTER DE GRUYTER GMBH
PI BERLIN
PA GENTHINER STRASSE 13, D-10785 BERLIN, GERMANY
SN 0334-018X
EI 2191-0251
J9 J PEDIATR ENDOCR MET
JI J. Pediatr. Endocrinol. Metab.
PD OCT
PY 2010
VL 23
IS 10
BP 1031
EP 1037
DI 10.1515/jpem.2010.164
PG 7
WC Endocrinology & Metabolism; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Pediatrics
GA 680OD
UT WOS:000284243400008
PM 21158214
DA 2025-06-11
ER

PT J
AU Tzormpatzakis, N
   Sleap, M
AF Tzormpatzakis, Nikolaos
   Sleap, Mike
TI Participation in physical activity and exercise in Greece: a systematic
   literature review
SO INTERNATIONAL JOURNAL OF PUBLIC HEALTH
LA English
DT Review
DE European Union; prevalence; leisure-time; health-enhancing;
   occupational; sports; sedentary
ID NATIONALLY REPRESENTATIVE SAMPLE; LEISURE-TIME; CARDIOVASCULAR-DISEASE;
   COAGULATION MARKERS; BODY-WEIGHT; LIFE-STYLE; UNIVERSITY-STUDENTS;
   METABOLIC SYNDROME; RISK-FACTORS; HEALTH
AB Objective: To review the evidence from research relevant to participation in physical activity and exercise in Greece.
   Method: Systematic search of peer-reviewed literature.
   Results: No such previous review was found for Greece. Thus, its originality should provide valuable information. Selected publications included 36 papers, published between 1993 and 2006, concerning 15 studies. Most studies investigated exercise, sports and leisure-time physical activity but total and occupational physical activity was also studied.
   Conclusion: Prevalence of physical activity and exercise in Greece was found to be low in the 1990s and 2000s, both in absolute and comparable terms. However, recent data reveal the development of a more active profile. The main reasons for participation were health, weight control, fitness and stress management, while lack of time was the main perceived barrier. Influencing factors were age, gender, income, type of work, marital status, residence and educational background. Recommendations include specific policies, strategies and campaigns to be addressed to the general public aiming at increasing participation rates. Future researchers should focus more on longitudinal and intervention studies.
C1 [Tzormpatzakis, Nikolaos; Sleap, Mike] Univ Hull, Dept Sport Hlth & Exercise Sci, Kingston Upon Hull HU6 7RX, N Humberside, England.
C3 University of Hull
RP Tzormpatzakis, N (corresponding author), Parodos Aldou Manoutiou 13, Iraklion 71409, Greece.
EM tzo23@yahoo.gr
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TC 17
Z9 18
U1 2
U2 23
PU SPRINGER BASEL AG
PI BASEL
PA PICASSOPLATZ 4, BASEL, 4052, SWITZERLAND
SN 1661-8556
EI 1661-8564
J9 INT J PUBLIC HEALTH
JI Int. J. Public Health
PY 2007
VL 52
IS 6
BP 360
EP 371
DI 10.1007/s00038-007-6118-6
PG 12
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA 249SG
UT WOS:000252249400010
PM 18368999
DA 2025-06-11
ER

PT J
AU Zhao, YF
   Han, XR
   Li, C
   Liu, YC
   Cheng, JY
   Adhikari, BK
   Wang, YG
AF Zhao, Yifan
   Han, Xiaorong
   Li, Cheng
   Liu, Yucheng
   Cheng, Jiayu
   Adhikari, Binay Kumar
   Wang, Yonggang
TI COVID-19 and the cardiovascular system: a study of pathophysiology and
   interpopulation variability
SO FRONTIERS IN MICROBIOLOGY
LA English
DT Review
DE SARS-CoV-2; COVID-19; cardiovascular disease; metabolic syndrome;
   endothelium; ACE2
ID ENDOTHELIAL DYSFUNCTION; OXIDATIVE STRESS; SOCIAL-ISOLATION;
   SEX-DIFFERENCES; RISK-FACTORS; MORTALITY; DISEASE; METAANALYSIS;
   INFECTION; ACE2
AB The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in humans can lead to various degrees of tissue and organ damage, of which cardiovascular system diseases are one of the main manifestations, such as myocarditis, myocardial infarction, and arrhythmia, which threaten the infected population worldwide. These diseases threaten the cardiovascular health of infected populations worldwide. Although the prevalence of coronavirus disease 2019 (COVID-19) has slightly improved with virus mutation and population vaccination, chronic infection, post-infection sequelae, and post-infection severe disease patients still exist, and it is still relevant to study the mechanisms linking COVID-19 to cardiovascular disease (CVD). This article introduces the pathophysiological mechanism of COVID-19-mediated cardiovascular disease and analyzes the mechanism and recent progress of the interaction between SARS-CoV-2 and the cardiovascular system from the roles of angiotensin-converting enzyme 2 (ACE2), cellular and molecular mechanisms, endothelial dysfunction, insulin resistance, iron homeostasis imbalance, and psychosocial factors, respectively. We also discussed the differences and mechanisms involved in cardiovascular system diseases combined with neocoronavirus infection in different populations and provided a theoretical basis for better disease prevention and management.
C1 [Zhao, Yifan; Li, Cheng; Cheng, Jiayu; Wang, Yonggang] First Hosp Jilin Univ, Dept Cardiovasc Ctr, Changchun, Peoples R China.
   [Han, Xiaorong] Chinese Acad Med Sci Peking Union Med Coll, Fuwai Hosp, Dept Special Care Ctr, Natl Clin Res Ctr Cardiovasc Dis,Natl Ctr Cardiova, Beijing, Peoples R China.
   [Liu, Yucheng] Northwestern Univ, Feinberg Sch Med, Dept Family & Community Med, McGaw Med Ctr, Chicago, IL USA.
   [Adhikari, Binay Kumar] Nepal Armed Police Force Hosp, Dept Cardiol, Kathmandu, Nepal.
C3 Jilin University; Chinese Academy of Medical Sciences - Peking Union
   Medical College; Peking Union Medical College; Fu Wai Hospital - CAMS;
   Northwestern University; Feinberg School of Medicine
RP Wang, YG (corresponding author), First Hosp Jilin Univ, Dept Cardiovasc Ctr, Changchun, Peoples R China.
EM wangyg1982@jlu.edu.cn
RI Han, Xiaorong/KFS-2490-2024; Zhao, Yifan/LLK-9216-2024
FU National Natural Science Foundation of China [82170362, 82000347]; Jilin
   Province Science and technology development plan project [20230508061RC,
   YDZJ202301ZYTS441]; China Postdoctoral Science Foundation [2021M691209];
   Jilin Medical and Health Talents Special [JLSWSRCZX2021-061]
FX Funding The study was supported by the National Natural Science
   Foundation of China (grant numbers: 82170362 to YW and 82000347 to CL).
   This study was also supported by Jilin Province Science and technology
   development plan project (grant numbers: 20230508061RC to YW and
   YDZJ202301ZYTS441 to CL), China Postdoctoral Science Foundation
   (2021M691209 to YW), and Jilin Medical and Health Talents Special
   (JLSWSRCZX2021-061 to YW).
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NR 102
TC 6
Z9 6
U1 2
U2 6
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1664-302X
J9 FRONT MICROBIOL
JI Front. Microbiol.
PD JUN 7
PY 2023
VL 14
AR 1213111
DI 10.3389/fmicb.2023.1213111
PG 10
WC Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Microbiology
GA J5RC2
UT WOS:001010177900001
PM 37350790
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Dulala, RK
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   Badrachalam, R
   Mani, V
AF Dulala, Rekha Kumari
   Balraj, Manikandan
   Chandrashekar, Sangeeta
   Muninathan, N.
   Rajapandiyan, Nithiya
   Badrachalam, Ramya
   Mani, Vadivel
TI Phytochemical cocktail of Asanadi gana extract in the
   management of diabetes
SO BIOINFORMATION
LA English
DT Article
DE Asanadi gana; Antioxidant; Organic radicals scavenging activity
ID OXIDATIVE STRESS; ANTIOXIDANTS; PROFILE
AB It is of interest to investigate that the phytochemical analysis, in-vitro antioxidant potential and glycosidase inhibitory potential of Asanadi gana a polyherbal formulation. Asanadi gana is a classical Ayurvedic polyherbal formulation, markedly used for alleviation of Prameha and medodosha, which correlates in many ways with obesity, metabolic syndrome, and diabetes mellitus (madhumeha). The phytochemical constituents, total phenolic, total flavonoids, total tannin content, total antioxidant capacity, total reducing power, and free radical scavenging activity of the polyherbal formulation extracts were determined. Comparing it to the common medication Acarbose, its inhibitory impact against the digestive enzymes alpha-amylase and alpha-glucosidase was also examined. The formulation showed the presence of major constituents such as terpenoids, triterpenoids, sterols, flavonoids, tannins, phenolic, saponins, alkaloids and Glycosides. The ethanol extract had high phenolic content and flavonoid content, whereas the aqueous extract had more tannin content (181 +/- 5.5 mu g/mg), (132 +/- 5.50 mu g/mg), (22 +/- 1.6 mu g/mg respectively. we conclude that the extracts of ayurvedic polyherbal formulations, particularly ethanol extract are a potential source of natural antioxidants and remarkable glycosidase inhibitory activity. Hence, Asanadi gana has the potential to be a safe and effective natural treatment for the delay or prevention of diabetic complications.
C1 [Dulala, Rekha Kumari; Mani, Vadivel] Konaseema Inst Med Sci & Res Fdn, Dept Biochem, Amalapuram 533201, Andhra Pradesh, India.
   [Balraj, Manikandan] Konaseema Inst Med Sci & Res Fdn, Dept Physiol, Amalapuram 533201, Andhra Pradesh, India.
   [Chandrashekar, Sangeeta] Bharath Inst Higher Educ & Res, Dept Physiol, Chennai 600073, Tamilnadu, India.
   [Muninathan, N.] Meenakshi Med Coll & Hosp, Cent Res Lab, Kanchipuram 631552, Tamilnadu, India.
   [Rajapandiyan, Nithiya] Arunai Med Coll & Hosp, Dept Physiol, Tiruvanamallai 606603, Tamilnadu, India.
   [Badrachalam, Ramya] Sri Manakula Vinayagar Med Coll & Hosp, Dept Biochem, Pondicherry 605107, Tamil Nadu, India.
C3 Bharath Institute of Higher Education & Research; Meenakshi Academy of
   Higher Education & Research (MAHER); Meenakshi Medical College Hospital
   & Research Institute
RP Mani, V (corresponding author), Konaseema Inst Med Sci & Res Fdn, Dept Biochem, Amalapuram 533201, Andhra Pradesh, India.
EM rekha.dulala@gmail.com; ayurveda@gmail.com; gsangeetakv@gmail.com;
   muninathanpappaiya@gmail.com; nithuran@gmail.com; drramya830@gmail.com;
   Velvdm.vel5@gmail.com
RI mani, vadivel/AET-3511-2022; Badrachalam, Ramya/JQW-7020-2023
OI Chandrashekar, Dr Sangeeta/0000-0001-6314-9812; M,
   vadivel/0000-0002-7592-7666
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NR 32
TC 0
Z9 0
U1 0
U2 1
PU BIOMEDICAL INFORMATICS
PI TAMIL NADU
PA NO 42, 2ND MAIN RD, CHENNAI, TAMIL NADU, 600 020, INDIA
SN 0973-8894
EI 0973-2063
J9 BIOINFORMATION
JI Bioinformation
PD MAR
PY 2023
VL 19
IS 3
BP 299
EP 306
DI 10.6026/97320630019299
PG 8
WC Mathematical & Computational Biology
WE Emerging Sources Citation Index (ESCI)
SC Mathematical & Computational Biology
GA E4PU6
UT WOS:000975386400015
PM 37808369
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Liu, L
   Feng, Q
   Wang, Y
   Zhao, XY
   Guo, SG
   Guo, L
   Liu, GS
   Jiang, LQ
   Li, Q
   Pan, BL
   Nie, JS
   Yang, J
AF Liu, Lu
   Feng, Quan
   Wang, Yong
   Zhao, Xinyu
   Guo, Shugang
   Guo, Lan
   Liu, Gaisheng
   Jiang, Liuquan
   Li, Qiang
   Pan, Baolong
   Nie, Jisheng
   Yang, Jin
TI Interaction of polycyclic aromatic hydrocarbon exposure and high-fasting
   plasma glucose on lung function decline in coke oven workers: a
   cross-lagged panel analysis
SO ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
LA English
DT Article
DE Polycyclic aromatic hydrocarbon; Fasting plasma glucose; Lung function;
   Cross-lagged panel analysis; Interaction effect
ID CANCER RISK-ASSESSMENT; OXIDATIVE STRESS; PULMONARY-FUNCTION; METABOLIC
   SYNDROME; MUSCLE STRENGTH; CENTRAL OBESITY; HEALTH; INFLAMMATION;
   ASSOCIATIONS; INDUCTION
AB Individuals with abnormal fasting plasma glucose (FPG) may be more susceptible to lung diseases associated with environmental pollutants. A cross-sectional survey of 629 workers in 2017 and a panel study of 304 workers from 2014 to 2019 were performed in China. The results showed that elevated total hydroxylated polycyclic aromatic hydrocarbon (EOH-PAH) concentration was associated with lower the percentage of predicted forced vital capacity (FVC%) among high-FPG workers (beta for the cross-sectional analysis:-1.78%, 95%CI:-2.92%,-0.64%; beta for the panel study:-1.10%, 95%CI:-2.19%,-0.02%). The absolute value of the cross-lagged path coefficient from FPG to FVC% (beta(2) =-0.096) was significantly greater than that from FVC% to FPG (beta(1) = 0.037). Our results suggest that FPG abnormalities may precede the lung function decline induced by PAH exposure and that high-FPG and high EOH-PAH levels have an interactive effect on lung function decline.
C1 [Liu, Lu; Feng, Quan; Wang, Yong; Zhao, Xinyu; Guo, Lan; Nie, Jisheng; Yang, Jin] Shanxi Med Univ, Sch Publ Hlth, Dept Occupat Hlth, Xinjiannan Rd 56, Taiyuan 030001, Shanxi, Peoples R China.
   [Guo, Shugang] Shanxi Prov Ctr Dis Control & Prevent, Xian, Peoples R China.
   [Liu, Gaisheng; Jiang, Liuquan; Li, Qiang] Xishan Coal Elect Grp Co Ltd, Ctr Occupat Dis Prevent, Taiyuan, Peoples R China.
   [Pan, Baolong] Taiyuan Iron & Steel Grp Co, Gen Hosp, Taiyuan, Peoples R China.
C3 Shanxi Medical University; Taiyuan Iron & Steel Group
RP Yang, J (corresponding author), Shanxi Med Univ, Sch Publ Hlth, Dept Occupat Hlth, Xinjiannan Rd 56, Taiyuan 030001, Shanxi, Peoples R China.
EM yang_jin@sxmu.edu.cn
RI Zhao, Xinyu/I-4198-2013
OI Nie, Jisheng/0000-0003-4351-2017
FU National Nature Science Foundation of China [81273041, 30901180]; Shanxi
   Scholarship Council of China [HGKY2019053]; Natural Science Foundation
   of Shanxi Province of China [201701D121146]
FX Funding information This work was supported by National Nature Science
   Foundation of China [No. 81273041 and 30901180] , Research Project
   Supported by Shanxi Scholarship Council of China [No. HGKY2019053] and
   Natural Science Foundation of Shanxi Province of China [No.
   201701D121146] .
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NR 58
TC 5
Z9 5
U1 1
U2 22
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1382-6689
EI 1872-7077
J9 ENVIRON TOXICOL PHAR
JI Environ. Toxicol. Pharmacol.
PD FEB
PY 2022
VL 90
AR 103811
DI 10.1016/j.etap.2022.103811
EA JAN 2022
PG 8
WC Environmental Sciences; Pharmacology & Pharmacy; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Pharmacology & Pharmacy; Toxicology
GA 0V3IY
UT WOS:000788239300006
PM 35038546
DA 2025-06-11
ER

PT J
AU Li, C
   Jenkins, S
   Considine, MM
   Cox, LA
   Gerow, KG
   Huber, HF
   Nathanielsz, PW
AF Li, Cun
   Jenkins, Susan
   Considine, McKenna M.
   Cox, Laura A.
   Gerow, Kenneth G.
   Huber, Hillary F.
   Nathanielsz, Peter W.
TI Effect of maternal obesity on fetal and postnatal baboon (Papio
   species) early life phenotype
SO JOURNAL OF MEDICAL PRIMATOLOGY
LA English
DT Article
DE ACTH; baboon; cortisol; developmental programming; fructose; high-energy
   diet; high-fat diet; maternal nutrition; non-human primates
ID GESTATIONAL WEIGHT-GAIN; BODY-MASS INDEX; PITUITARY-ADRENAL AXIS;
   BIRTH-WEIGHT; METABOLIC SYNDROME; EXPERIMENTAL-MODELS; NUTRIENT
   REDUCTION; PREGNANCY; CORTISOL; STRESS
AB Background Non-human primate models of developmental programming by maternal obesity (MO) are needed for translation to human programming outcomes. We present baboon offspring (F1) morphometry, blood cortisol, and adrenocorticotropic hormone (ACTH) from 0.9 gestation to 0-2 years. Methods Control mothers ate chow; MO mothers ate high-fat high-energy diet pre-pregnancy through lactation. Results Maternal obesity mothers weighed more than controls pre-pregnancy. Maternal obesity gestational weight gain was lower with no correlation with fetal or placenta weights. At 0.9 gestation, MO and control F1 morphometry and ACTH were similar. MO-F1 0.9 gestation male cortisol was lower, rising slower from 0-2 years vs control-F1. At birth, male MO-F1 and control-F1 weights were similar, but growth from 0-2 years was steeper in MO-F1; newborn female MO-F1 weighed more than control-F1 but growth from 0-2 years was similar. ACTH did not change in either sex. Conclusions Maternal obesity produced sexually dimorphic fetal and postnatal growth and hormonal phenotypes.
C1 [Li, Cun; Jenkins, Susan; Considine, McKenna M.; Huber, Hillary F.; Nathanielsz, Peter W.] Univ Wyoming, Dept Anim Sci, Texas Pregnancy & Life Course Hlth Ctr, Laramie, WY 82071 USA.
   [Li, Cun; Cox, Laura A.; Nathanielsz, Peter W.] Texas Biomed Res Inst, Southwest Natl Primate Res Ctr, San Antonio, TX 78227 USA.
   [Cox, Laura A.] Wake Forest Sch Med, Ctr Precis Med, Sect Mol Med, Dept Internal Med, Winston Salem, NC USA.
   [Gerow, Kenneth G.] Univ Wyoming, Dept Stat, Laramie, WY 82071 USA.
C3 University of Wyoming; Texas Biomedical Research Institute; Wake Forest
   University; University of Wyoming
RP Nathanielsz, PW (corresponding author), Texas Biomed Res Inst, Southwest Natl Primate Res Ctr, San Antonio, TX 78227 USA.
EM peter.nathanielsz@uwyo.edu
OI Nathanielsz, Peter/0000-0001-8410-6280
FU  [HD21350];  [R24OD010916]
FX This work was supported by HD21350 and R24OD010916.
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NR 58
TC 8
Z9 9
U1 0
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0047-2565
EI 1600-0684
J9 J MED PRIMATOL
JI J. Med. Primatol.
PD APR
PY 2019
VL 48
IS 2
BP 90
EP 98
DI 10.1111/jmp.12396
PG 9
WC Veterinary Sciences; Zoology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences; Zoology
GA HO1UC
UT WOS:000460695600003
PM 30569595
OA Green Accepted
DA 2025-06-11
ER

PT J
AU McGillick, EV
   Lock, MC
   Orgeig, S
   Morrison, JL
AF McGillick, Erin V.
   Lock, Mitchell C.
   Orgeig, Sandra
   Morrison, Janna L.
TI Maternal obesity mediated predisposition to respiratory complications at
   birth and in later life: understanding the implications of the
   obesogenic intrauterine environment
SO PAEDIATRIC RESPIRATORY REVIEWS
LA English
DT Article
DE Maternal obesity; ovemutrition; fetal lung; respiratory complications;
   pulmonary surfactant; fatty acid metabolism; developmental programming;
   metabolic syndrome; gestational diabetes
ID PITUITARY-ADRENAL AXIS; GESTATIONAL WEIGHT-GAIN; BODY-MASS INDEX;
   OXIDATIVE STRESS; RISK-FACTORS; LONGITUDINAL CHANGES; GLUCOSE-INFUSION;
   LUNG DEVELOPMENT; SURFACTANT; PREGNANCY
AB More women than not are entering pregnancy either overweight or obese. This presents a significant health care burden with respect to maternal morbidities and offspring complications at birth and in later life. In recent years it has also become clear that maternal obesity is an even greater global health problem than anticipated, because the effects are not limited to the mother but are also programmed in the fetus, known as the 'intergenerational cycle of obestiy'. Despite a large body of epidemiological evidence reporting outcomes of obese pregnancies, including offspring respiratory complications, much less is known about the molecular effects of maternal obesity on fetal lung development. This review focuses on the influence of altered substrate supply associated with the obesogenic intrauterine environment on fetal lung development. Understanding the molecular mechanisms contributing to altered fetal lung development will lead to improved respiratory outcomes for offspring at birth and in later life. (C) 2016 Elsevier Ltd. All rights reserved.
C1 [McGillick, Erin V.; Lock, Mitchell C.; Morrison, Janna L.] Univ South Australia, Early Origins Adult Hlth Res Grp, Adelaide, SA, Australia.
   [McGillick, Erin V.; Orgeig, Sandra] Univ South Australia, Sansom Inst Hlth Res, Sch Pharm & Med Sci, Mol & Evolutionary Physiol Lung Lab, Adelaide, SA, Australia.
C3 University of South Australia; University of South Australia
RP Morrison, JL (corresponding author), Univ South Australia, Early Origins Adult Hlth Res Grp, Adelaide, SA, Australia.
EM Erin.mcgillick@mymail.unisa.edu.au; Mitchell.lock@mymail.unisa.edu.au;
   Sandra.Orgeig@unisa.edu.au; Janna.Morrison@unisa.edu.au
RI ; Orgeig, Sandra/B-8476-2009; Morrison, Janna/B-8308-2009
OI McGillick, Erin/0000-0002-9849-5958; Orgeig, Sandra/0000-0003-0849-2209;
   Lock, Mitchell/0000-0002-3594-1455; Morrison, Janna/0000-0002-8602-8519
FU NHMRC Career Development Fellowship [APP1066916]
FX JLM was funded by a NHMRC Career Development Fellowship (APP1066916).
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NR 81
TC 40
Z9 42
U1 0
U2 10
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1526-0542
EI 1526-0550
J9 PAEDIATR RESPIR REV
JI Paediatr. Respir. Rev.
PD JAN
PY 2017
VL 21
BP 11
EP 18
DI 10.1016/j.prrv.2016.10.003
PG 8
WC Pediatrics; Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics; Respiratory System
GA EL2US
UT WOS:000394476300003
PM 27818069
DA 2025-06-11
ER

PT J
AU Schutkowski, M
   Fischer, F
   Roessler, C
   Steegborn, C
AF Schutkowski, Mike
   Fischer, Frank
   Roessler, Claudia
   Steegborn, Clemens
TI New assays and approaches for discovery and design of Sirtuin modulators
SO EXPERT OPINION ON DRUG DISCOVERY
LA English
DT Review
DE activator; activity assay; deacetylases; deacylases; drug development;
   inhibitor; mechanism; modulators; Sirtuin; substrate-specific modulation
ID HISTONE DEACETYLASE ACTIVITY; DEPENDENT PROTEIN DEACETYLASES;
   SMALL-MOLECULE ACTIVATORS; LYSINE ACETYLATION; SIR2 FAMILY;
   POSTTRANSLATIONAL MODIFICATIONS; SACCHAROMYCES-CEREVISIAE; ADP-RIBOSE;
   IN-VIVO; HISTONE/PROTEIN DEACETYLASES
AB Introduction: Sirtuins are an evolutionarily conserved family of NAD(+)-dependent protein lysine deacylases. In mammals, 7 Sirtuin isoforms control various functions in metabolism, stress responses and aging processes. Sirtuins are considered attractive therapeutic targets for metabolic and aging-related diseases, such as metabolic syndrome and neurodegenerative disorders. Extensive development efforts on small-molecule Sirtuin inhibitors and activators have yielded few potent and selective compounds, partly due to shortcomings of available assays and a lack of mechanistic characterization of identified compounds.
   Areas covered: The authors describe the developments in analyzing Sirtuin activity and conceptual advances in the identification, improvement and design of Sirtuin-modulating compounds. They also review the application of these methods and concepts for the development and mechanistic characterization of Sirtuin modulators.
   Expert opinion: Novel assays and experimental approaches for studying Sirtuin activity have been instrumental for major progress in understanding functions of Sirtuins and how these enzymes can be modulated with drugs. The improved tools and mechanistic insights now enable a more efficient development of Sirtuin modulators for in vivo studies and therapeutic applications.
C1 [Schutkowski, Mike; Roessler, Claudia] Univ Halle Wittenberg, Inst Biochem & Biotechnol, Dept Enzymol, D-06108 Halle, Germany.
   [Fischer, Frank; Steegborn, Clemens] Univ Bayreuth, Dept Biochem, D-95447 Bayreuth, Germany.
   [Fischer, Frank; Steegborn, Clemens] Univ Bayreuth, Res Ctr Biomacromol, D-95447 Bayreuth, Germany.
C3 Martin Luther University Halle Wittenberg; University of Bayreuth;
   University of Bayreuth
RP Steegborn, C (corresponding author), Univ Bayreuth, Dept Biochem, POB 101251, D-95447 Bayreuth, Germany.
RI Staels, Bart/N-9497-2016
OI Schutkowski, MIke/0000-0003-0919-7076
FU Deutsche Forschungsgemeinschaft [STE1701/5]; BMBF [ProNet-T3]
FX Work on Sirtuins in the authors' lab was partially supported by Deutsche
   Forschungsgemeinschaft (grant STE1701/5) to C Steegborn and BMBF grant
   ProNet-T3 to M Schutkowski.
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NR 118
TC 46
Z9 46
U1 1
U2 27
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1746-0441
EI 1746-045X
J9 EXPERT OPIN DRUG DIS
JI Expert. Opin. Drug Discov.
PD FEB
PY 2014
VL 9
IS 2
BP 183
EP 199
DI 10.1517/17460441.2014.875526
PG 17
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 294VA
UT WOS:000330074400007
PM 24382304
DA 2025-06-11
ER

PT J
AU Brumbaugh, DE
   Friedman, JE
AF Brumbaugh, David E.
   Friedman, Jacob E.
TI Developmental origins of nonalcoholic fatty liver disease
SO PEDIATRIC RESEARCH
LA English
DT Review
ID BODY-MASS INDEX; GUT MICROBIOME; INSULIN-RESISTANCE; METABOLIC-SYNDROME;
   MATERNAL OBESITY; INCREASING PREVALENCE; PREPREGNANCY OBESITY; HEPATIC
   STEATOSIS; ACID-METABOLISM; GENE-EXPRESSION
AB Obese pregnant women may transmit their metabolic phenotype to offspring, leading to a cycle of obesity and diabetes over generations. Early childhood obesity predicts nonalcoholic fatty liver disease (NAFLD), the most common chronic human liver disease. The fetus may be vulnerable to steatosis because immature fetal adipose depots are not available to buffer the excess transplacental lipid delivery in maternal obesity. In animal models, in utero high-fat diet exposure results in an increase in the accumulation of liver triglycerides in offspring and increased hepatic oxidative stress and apoptosis, perhaps priming the liver for later development of NAFLD. Innate immune dysfunction and necroinflammatory changes have been observed in postnatal offspring liver of animals born to high-fat fed dams. Postweaning, livers of offspring exposed to maternal high-fat feeding in utero share pathophysiologic features with human NAFLD, including increased de novo lipogenesis and decreased free fatty acid oxidation. Human studies using magnetic resonance imaging have shown that maternal BMI predicts infant intrahepatocellular lipid storage, as seen in animal, models. The generational transfer of NAFLD may occur via epigenetic changes in offspring liver.Transmission of microbiota from mother to infant may impact energy retention and immune function that contribute to a predisposition to NAFLD.
C1 [Brumbaugh, David E.; Friedman, Jacob E.] Univ Colorado, Sch Med, Dept Pediat, Aurora, CO 80045 USA.
   [Friedman, Jacob E.] Univ Colorado, Sch Med, Dept Biochem & Mol Genet, Aurora, CO USA.
C3 University of Colorado System; University of Colorado Anschutz Medical
   Campus; University of Colorado System; University of Colorado Anschutz
   Medical Campus
RP Brumbaugh, DE (corresponding author), Univ Colorado, Sch Med, Dept Pediat, Aurora, CO 80045 USA.
EM david.brumbaugh@childrenscolorado.org
FU National Institutes of Health (Bethesda, MD) [DK-090964, DK-077630,
   DK-078645, DK-088324]
FX This study was supported by National Institutes of Health (Bethesda,
   MD): DK-090964, DK-077630, DK-078645, and DK-088324.
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NR 77
TC 117
Z9 130
U1 0
U2 49
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0031-3998
EI 1530-0447
J9 PEDIATR RES
JI Pediatr. Res.
PD JAN
PY 2014
VL 75
IS 1
BP 140
EP 147
DI 10.1038/pr.2013.193
PN 2
PG 8
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA AA5RU
UT WOS:000331158100005
PM 24192698
OA Bronze, Green Accepted
DA 2025-06-11
ER

PT J
AU White, DL
   Collinson, A
AF White, Desley L.
   Collinson, Avril
TI Red Meat, Dietary Heme Iron, and Risk of Type 2 Diabetes: The
   Involvement of Advanced Lipoxidation Endproducts
SO ADVANCES IN NUTRITION
LA English
DT Review
ID GLYCATION END-PRODUCTS; FREE FATTY-ACIDS; INSULIN-RESISTANCE; SERUM
   FERRITIN; METABOLIC SYNDROME; ENDOTHELIAL FUNCTION; OXIDATIVE STRESS;
   CONSUMPTION; STORES; MEN
AB There is growing evidence of disordered iron homeostasis in the diabetic condition, with links proposed between dietary iron intakes and both the risk of disease and the risk of complications of advanced disease. In the United States, Britain, and Canada, the largest dietary contributors of iron are cereals and cereal products and meat and meat products. This review discusses the findings of cohort studies and meta-analyses of heme iron and red meat intakes and the risk of type 2 diabetes. These suggest that processed red meat is associated with increased risk, with high intakes of red meat possibly also associated with a small increased risk. Historically, humans have relied on large quantities of heme iron and red meat in their diets, and therefore it is paradoxical that iron from meat sources should be associated with the risk of type 2 diabetes. A reason for this association may be drawn from studies of dietary advanced glycation and lipoxidation endproducts present in processed food and the mechanisms by which insulin output by pancreatic islet cells might be influenced by the protein modifications present in processed red meat.
C1 [White, Desley L.; Collinson, Avril] Univ Plymouth, Sch Hlth Profess, Peninsula Allied Hlth Ctr, Plymouth PL4 8AA, Devon, England.
C3 University of Plymouth
RP White, DL (corresponding author), Univ Plymouth, Sch Hlth Profess, Peninsula Allied Hlth Ctr, Plymouth PL4 8AA, Devon, England.
EM desley.white@plymouth.ac.uk
OI Collinson, Avril/0000-0001-5046-7344
FU Plymouth University
FX Supported by a Plymouth University Dean's Studentship.
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NR 112
TC 52
Z9 58
U1 1
U2 47
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 2161-8313
EI 2156-5376
J9 ADV NUTR
JI Adv. Nutr.
PD JUL
PY 2013
VL 4
IS 4
BP 403
EP 411
DI 10.3945/an.113.003681
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 201KR
UT WOS:000323141000001
PM 23858089
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Bazuine, M
   Stenkula, KG
   Cam, M
   Arroyo, M
   Cushman, SW
AF Bazuine, Merlijn
   Stenkula, Karin G.
   Cam, Maggie
   Arroyo, Mathilde
   Cushman, Samuel W.
TI Guardian of corpulence: a hypothesis on p53 signaling in the fat cell
SO CLINICAL LIPIDOLOGY
LA English
DT Review
DE adipogenesis; diabetes; lipotoxicity; oxysterol; p53
ID ACTIVATED-RECEPTOR-GAMMA; OXYSTEROL-BINDING-PROTEIN; PROMOTES ADIPOCYTE
   DIFFERENTIATION; RAT ADIPOSE-CELLS; PPAR-GAMMA; INSULIN-RESISTANCE;
   LIPID DROPLETS; GENE-EXPRESSION; TRANSCRIPTION-FACTOR; METABOLIC
   SYNDROME
AB Adipocytes provide an organism with fuel in times of caloric deficit, and are an important type of endocrine cell in the maintenance of metabolic homeostasis. In addition, as a lipid-sink, adipocytes serve an equally important role in the protection of organs from the damaging effects of ectopic lipid deposition. For the organism, it is of vital importance to maintain adipocyte viability, yet the fat depot is a demanding extracellular environment with high levels of interstitial free fatty acids and associated lipotoxic effects. These surroundings are less than beneficial for the overall health of any resident cell, adipocyte and preadipocyte alike. In this review, we discuss the process of adipogenesis and the potential involvement of the p53 tumor-suppressor protein in alleviating some of the cellular stress experienced by these cells. In particular, we discuss p53-mediated mechanisms that prevent damage caused by reactive oxygen species and the effects of lipotoxicity. We also suggest the potential for two p53 target genes, START domain-containing protein 4 (StARD4) and oxysterol-binding protein (OSBP), with the concomitant synthesis of the signaling molecule oxysterol, to participate in adipogenesis.
C1 [Bazuine, Merlijn; Stenkula, Karin G.; Cam, Maggie; Arroyo, Mathilde; Cushman, Samuel W.] NIDDK, Expt Diabet Metab & Nutr Sect, Diabet Branch, NIH, Bethesda, MD 20892 USA.
C3 National Institutes of Health (NIH) - USA; NIH National Institute of
   Diabetes & Digestive & Kidney Diseases (NIDDK)
RP Bazuine, M (corresponding author), NIDDK, Expt Diabet Metab & Nutr Sect, Diabet Branch, NIH, Bldg 10 CRC,Room 5W-5816,10 Ctr Dr, Bethesda, MD 20892 USA.
EM bazuinem@niddk.nih.gov
RI Cushman, Samuel/IWM-0020-2023
OI Stenkula, Karin G/0000-0002-0739-1150
FU Intramural NIH HHS [NIH0011646659, Z01 DK075014] Funding Source: Medline
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NR 139
TC 19
Z9 19
U1 0
U2 4
PU FUTURE MEDICINE LTD
PI LONDON
PA UNITEC HOUSE, 3RD FLOOR, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON, N3
   1QB, ENGLAND
SN 1758-4299
J9 CLIN LIPIDOL
JI Clin. Lipidol.
PD APR
PY 2009
VL 4
IS 2
BP 231
EP 243
DI 10.2217/CLP.09.2
PG 13
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 450EF
UT WOS:000266383100014
PM 20126301
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Ionita-Radu, F
   Patoni, C
   Nancoff, AS
   Marin, FS
   Gaman, L
   Bucurica, A
   Socol, C
   Jinga, M
   Dutu, M
   Bucurica, S
AF Ionita-Radu, Florentina
   Patoni, Cristina
   Nancoff, Andreea Simona
   Marin, Flavius-Stefan
   Gaman, Laura
   Bucurica, Ana
   Socol, Calin
   Jinga, Mariana
   Dutu, Madalina
   Bucurica, Sandica
TI Berberine Effects in Pre-Fibrotic Stages of Non-Alcoholic Fatty Liver
   Disease-Clinical and Pre-Clinical Overview and Systematic Review of the
   Literature
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE non-alcoholic fatty liver disease (NAFLD); non-alcoholic steatohepatitis
   (NASH); berberine; fatty liver; liver steatosis; metabolic
   dysfunction-associated fatty liver disease (MAFLD)
ID HEPATIC LIPID-ACCUMULATION; OXIDATIVE STRESS; MESSENGER-RNA; ADDITIONAL
   MECHANISM; METABOLIC SYNDROME; ADIPOSE-TISSUE; STEATOHEPATITIS; DIET;
   ACTIVATION; STEATOSIS
AB Non-alcoholic fatty liver disease (NAFLD) is the predominant cause of chronic liver conditions, and its progression is marked by evolution to non-alcoholic steatosis, steatohepatitis, cirrhosis related to non-alcoholic steatohepatitis, and the potential occurrence of hepatocellular carcinoma. In our systematic review, we searched two databases, Medline (via Pubmed Central) and Scopus, from inception to 5 February 2024, and included 73 types of research (nine clinical studies and 64 pre-clinical studies) from 2854 published papers. Our extensive research highlights the impact of Berberine on NAFLD pathophysiology mechanisms, such as Adenosine Monophosphate-Activated Protein Kinase (AMPK), gut dysbiosis, peroxisome proliferator-activated receptor (PPAR), Sirtuins, and inflammasome. Studies involving human subjects showed a measurable reduction of liver fat in addition to improved profiles of serum lipids and hepatic enzymes. While current drugs for NAFLD treatment are either scarce or still in development or launch phases, Berberine presents a promising profile. However, improvements in its formulation are necessary to enhance the bioavailability of this natural substance.
C1 [Ionita-Radu, Florentina; Patoni, Cristina; Marin, Flavius-Stefan; Jinga, Mariana; Bucurica, Sandica] Carol Davila Univ Med & Pharm, Dept Gastroenterol, Bucharest 020021, Romania.
   [Ionita-Radu, Florentina; Nancoff, Andreea Simona; Jinga, Mariana; Bucurica, Sandica] Dr Carol Davila Cent Mil Emergency Univ Hosp, Dept Gastroenterol, Bucharest 010242, Romania.
   [Gaman, Laura] Carol Davila Univ Med & Pharm, Dept Biochem, Bucharest 020021, Romania.
   [Bucurica, Ana; Socol, Calin] Carol Davila Univ Med & Pharm, Fac Gen Med, Bucharest 020021, Romania.
   [Dutu, Madalina] Carol Davila Univ Med & Pharm, Dept Anesthesiol & Intens Care, Bucharest 020021, Romania.
   [Dutu, Madalina] Dr Carol Davila Cent Mil Emergency Univ Hosp, Dept Anesthesiol & Intens Care, Bucharest 010242, Romania.
C3 Carol Davila University of Medicine & Pharmacy; Carol Davila University
   of Medicine & Pharmacy; Carol Davila University of Medicine & Pharmacy;
   Carol Davila University of Medicine & Pharmacy
RP Jinga, M (corresponding author), Carol Davila Univ Med & Pharm, Dept Gastroenterol, Bucharest 020021, Romania.; Jinga, M (corresponding author), Dr Carol Davila Cent Mil Emergency Univ Hosp, Dept Gastroenterol, Bucharest 010242, Romania.; Dutu, M (corresponding author), Carol Davila Univ Med & Pharm, Dept Anesthesiol & Intens Care, Bucharest 020021, Romania.; Dutu, M (corresponding author), Dr Carol Davila Cent Mil Emergency Univ Hosp, Dept Anesthesiol & Intens Care, Bucharest 010242, Romania.
EM florentina.ionita-radu@umfcd.ro; cristina.patoni@drd.umfcd.ro;
   andreea-simona.nancoff@rez.umfcd.ro; flaviusstefanmarin@gmail.com;
   laura.gaman@umfcd.ro; ana.bucurica@stud.umfcd.ro;
   calin.socol@stud.umfcd.ro; mariana.jinga@umfcd.ro;
   madalina.dutu@umfcd.ro; sandica.bucurica@umfcd.ro
RI Jinga, Mariana/AAA-7101-2022; Patoni, Cristina/JGM-4582-2023; gaman,
   laura/MEO-0202-2025; Ionita Radu, Florentina/ADP-0898-2022; Dutu,
   Madalina/A-4151-2019; Bucurica, Sandica/HIR-3104-2022
OI Marin, Flavius-Stefan/0000-0003-3475-7725; Ionita Radu,
   Florentina/0000-0001-9829-5035; Socol, Calin Lucian/0000-0001-7598-8998;
   Jinga, Mariana/0000-0001-5826-0815; Gaman, Laura/0000-0002-8181-1803;
   Dutu, Madalina/0009-0006-5511-8702; Bucurica,
   Sandica/0000-0002-8787-3829; Patoni, Cristina/0000-0001-5541-7151
FU Carol Davila University of Medicine and Pharmacy through the
   institutional program Publish
FX No Statement Available
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NR 159
TC 5
Z9 6
U1 6
U2 11
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD APR
PY 2024
VL 25
IS 8
AR 4201
DI 10.3390/ijms25084201
PG 32
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA QJ6R6
UT WOS:001220551500001
PM 38673787
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Martínez-García, JJ
   Rainteau, D
   Humbert, L
   Lamaziere, A
   Lesnik, P
   Chamaillard, M
AF Martinez-Garcia, Juan Jose
   Rainteau, Dominique
   Humbert, Lydie
   Lamaziere, Antonin
   Lesnik, Philippe
   Chamaillard, Mathias
TI Diurnal Interplay between Epithelium Physiology and Gut Microbiota as a
   Metronome for Orchestrating Immune and Metabolic Homeostasis
SO METABOLITES
LA English
DT Review
DE aging; antimicrobial peptides; bile acids; circadian rhythms; diurnal
   oscillations in gut microbiota composition; intestinal epithelial cells;
   mucus; short-chain fatty acids
ID FATTY-ACID OXIDATION; CIRCADIAN CLOCK; PPAR-GAMMA; STEM-CELLS;
   GENE-EXPRESSION; PRODUCTS; ASSOCIATION; SECRETION; RHYTHMS; DIET
AB The behavior and physiology of most organisms are temporally coordinated and aligned with geophysical time by a complex interplay between the master and peripheral clocks. Disruption of such rhythmic physiological activities that are hierarchically organized has been linked to a greater risk of developing diseases ranging from cancer to metabolic syndrome. Herein, we summarize the molecular clockwork that is employed by intestinal epithelial cells to anticipate environmental changes such as rhythmic food intake and potentially dangerous environmental stress. We also discuss recent discoveries contributing to our understanding of how a proper rhythm of intestinal stem cells may achieve coherence for the maintenance of tissue integrity. Emerging evidence indicates that the circadian oscillations in the composition of the microbiota may operate as an important metronome for the proper preservation of intestinal physiology and more. Furthermore, in this review, we outline how epigenetic clocks that are based on DNA methylation levels may extensively rewire the clock-controlled functions of the intestinal epithelium that are believed to become arrhythmic during aging.
C1 [Martinez-Garcia, Juan Jose; Chamaillard, Mathias] Univ Lille, Lab Cell Physiol, INSERM U1003, F-59019 Lille, France.
   [Rainteau, Dominique; Humbert, Lydie; Lamaziere, Antonin] Sorbonne Univ, Hop St Antoine, AP HP SU, Ctr Rech St Antoine,Dept Metab Clin, F-75012 Paris, France.
   [Lesnik, Philippe] Sorbonne Univ, INSERM, UMR S 1166, ICAN, F-75012 Paris, France.
   [Lesnik, Philippe] Hop La Pitie Salpetriere, Fac Med, Res Inst Cardiovasc Dis Metab & Nutr, F-75013 Paris, France.
C3 Universite de Lille; Institut National de la Sante et de la Recherche
   Medicale (Inserm); Assistance Publique Hopitaux Paris (APHP); Sorbonne
   Universite; Hopital Universitaire Saint-Antoine - APHP; Institut
   National de la Sante et de la Recherche Medicale (Inserm); Sorbonne
   Universite; Institut National de la Sante et de la Recherche Medicale
   (Inserm); Sorbonne Universite; Assistance Publique Hopitaux Paris
   (APHP); Hopital Universitaire Pitie-Salpetriere - APHP
RP Chamaillard, M (corresponding author), Univ Lille, Lab Cell Physiol, INSERM U1003, F-59019 Lille, France.
EM juan-jose.martinez-garcia@inserm.fr;
   dominique.rainteau@sorbonne-universite.fr;
   lydie.humbert@sorbonne-universite.fr;
   antoninlamaziere@sorbonne-universite.fr; philippe.lesnik@upmc.fr;
   mathias.chamaillard@inserm.fr
RI Lamaziere, Antonin/AFM-0000-2022; Chamaillard, Mathias/L-6542-2013;
   Lesnik, Philippe/AAD-7393-2020; Martinez-Garcia, Juan Jose/U-7439-2018
OI Martinez-Garcia, Juan Jose/0000-0003-2997-8419; Lesnik,
   Philippe/0000-0002-6909-7715
FU Institut National de la Sante et de la Recherche Medicale through the
   French transversal program on microbiota [R21091EK/RSE21091EKA];
   Fondation pour La Recherche Medicale
FX This research was supported by funding to D.R., A.M., P.L. and M.C. from
   the Institut National de la Sante et de la Recherche Medicale through
   the French transversal program on microbiota (Grant No.
   R21091EK/RSE21091EKA). J.J.M.G. was a recipient of a fellowship funded
   by the Fondation pour La Recherche Medicale.
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NR 68
TC 3
Z9 3
U1 1
U2 11
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2218-1989
J9 METABOLITES
JI Metabolites
PD MAY
PY 2022
VL 12
IS 5
AR 390
DI 10.3390/metabo12050390
PG 12
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 1Q4QT
UT WOS:000802674700001
PM 35629894
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Cheimonidi, C
   Grivas, IN
   Sesti, F
   Kavrochorianou, N
   Gianniou, DD
   Taoufik, E
   Badounas, F
   Papassideri, I
   Rizzi, F
   Tsitsilonis, OE
   Haralambous, S
   Trougakos, IP
AF Cheimonidi, Christina
   Grivas, Ioannis N.
   Sesti, Fabiola
   Kavrochorianou, Nadia
   Gianniou, Despoina D.
   Taoufik, Era
   Badounas, Fotis
   Papassideri, Issidora
   Rizzi, Federica
   Tsitsilonis, Ourania E.
   Haralambous, Sylva
   Trougakos, Ioannis P.
TI Clusterin overexpression in mice exacerbates diabetic phenotypes but
   suppresses tumor progression in a mouse melanoma model
SO AGING-US
LA English
DT Article
DE cancer; chaperone; clusterin; diabetes; proteostasis
ID CORONARY-HEART-DISEASE; INSULIN-RESISTANCE; APOLIPOPROTEIN J/CLUSTERIN;
   CLUSTERIN/APOLIPOPROTEIN-J; OXIDATIVE-PHOSPHORYLATION; CANCER-CELLS;
   STRESS; GLUCONEOGENESIS; METABOLISM; EXPRESSION
AB Clusterin (CLU) is an ATP-independent small heat shock protein-like chaperone, which functions both intra-and extra-cellularly. Consequently, it has been functionally involved in several physiological (including aging), as well as in pathological conditions and most age-related diseases, e.g., cancer, neurodegeneration, and metabolic syndrome. To address CLU function at an in vivo model we established CLU transgenic (Tg) mice bearing ubiquitous or pancreas-targeted CLU overexpression (OE). Our downstream analyses in established Tg lines showed that ubiquitous or pancreas-targeted CLU OE in mice affected antioxidant, proteostatic and metabolic pathways. Targeted OE of CLU in the pancreas, which also resulted in CLU upregulation in the liver likely via systemic effects, increased basal glucose levels in the circulation and exacerbated diabetic phenotypes. Furthermore, by establishing a syngeneic melanoma mouse tumor model we found that ubiquitous CLU OE suppressed melanoma cells growth, indicating a likely tumor suppressor function in early phases of tumorigenesis. Our observations provide in vivo evidence corroborating the notion that CLU is a potential modulator of metabolic and/or proteostatic pathways playing an important role in diabetes and tumorigenesis.
C1 [Cheimonidi, Christina; Sesti, Fabiola; Gianniou, Despoina D.; Papassideri, Issidora; Trougakos, Ioannis P.] Natl & Kapodistrian Univ Athens, Fac Biol, Dept Cell Biol & Biophys, Athens 15784, Greece.
   [Grivas, Ioannis N.; Kavrochorianou, Nadia; Badounas, Fotis; Haralambous, Sylva] Hellenic Pasteur Inst, Transgen Technol Lab, Dept Immunol, Inflammat Res Lab, Athens 11521, Greece.
   [Taoufik, Era] Hellenic Pasteur Inst, Lab Cellular & Mol Neurobiol Stem Cells, Athens 11521, Greece.
   [Rizzi, Federica] Univ Parma, Dipartimento Med & Chirurg, I-43125 Parma, Italy.
   [Rizzi, Federica] Ist Nazl Biostrutture & Biosistemi INBB, I-00136 Rome, Italy.
   [Tsitsilonis, Ourania E.] Natl & Kapodistrian Univ Athens, Fac Biol, Dept Anim & Human Physiol, Athens 15784, Greece.
C3 National & Kapodistrian University of Athens; University of Parma;
   National & Kapodistrian University of Athens
RP Trougakos, IP (corresponding author), Natl & Kapodistrian Univ Athens, Fac Biol, Dept Cell Biol & Biophys, Athens 15784, Greece.
EM itrougakos@biol.uoa.gr
RI Tsitsilonis, Ourania/AAF-3168-2019; Trougakos, Ioannis/R-6149-2018;
   BADOUNAS, FOTIOS/AAT-1888-2021
OI BADOUNAS, FOTIOS/0000-0001-7539-7602; Cheimonidi,
   Christina/0000-0003-0761-0648
FU National and Kapodistrian University of Athens
FX We thank Prof Saverio Bettuzzi (University of Parma, Italy) for donating
   mouse CLU cDNA and Triantaphillia Ntouroupi, PhD (National and
   Kapodistrian University of Athens, Greece) for plasmids sequencing. DDG
   is supported by a "Stavros Tsakyrakis" PhD fellowship from the National
   and Kapodistrian University of Athens. We also thank Dr Eirini
   Fragiadaki (responsible MD V) , FELASA accreditation B/C/D) and the
   personnel of the Dept of Animal Models for Biomedical Research of the
   Hellenic Pasteur Institute, Greece for assisting during mice handling
   and maintenance.
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NR 55
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Z9 3
U1 0
U2 2
PU IMPACT JOURNALS LLC
PI ORCHARD PARK
PA 6666 E QUAKER ST, STE 1, ORCHARD PARK, NY 14127 USA
SN 1945-4589
J9 AGING-US
JI Aging-US
PD MAR 15
PY 2021
VL 13
IS 5
BP 6485
EP 6505
PG 21
WC Cell Biology; Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Geriatrics & Gerontology
GA QX8TQ
UT WOS:000629616300017
PM 33744871
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Ma, LY
   Ni, YH
   Hu, LT
   Zhao, YF
   Zheng, LJ
   Yang, S
   Ni, LY
   Fu, ZW
AF Ma, Lingyan
   Ni, Yinhua
   Hu, Luting
   Zhao, Yufeng
   Zheng, Liujie
   Yang, Song
   Ni, Liyang
   Fu, Zhengwei
TI Spermidine ameliorates high-fat diet-induced hepatic steatosis and
   adipose tissue inflammation in preexisting obese mice
SO LIFE SCIENCES
LA English
DT Article
DE Obesity; Spermidine; Hepatic steatosis; Inflammation; Gut barrier
ID INSULIN-RESISTANCE; ENERGY-EXPENDITURE; OXIDATIVE STRESS;
   LIPID-METABOLISM; LIVER; MECHANISMS; PROTECTS; ACCUMULATION;
   MACROPHAGES; EXPRESSION
AB Aims: The therapeutic effects of spermidine on preexisting obese mice have been not fully elucidated. In this study, we assessed the anti-obesity impact of spermidine on high-fat diet (HFD)-induced obese mice.
   Main methods: C57BL/6J mice were fed a HFD for 16 weeks to induce obesity, and then treated with or without spermidine via drinking water for additional 8 weeks. The contributions of spermidine in regulating obesity phenotypes and metabolic syndrome were further evaluated.
   Key findings: Spermidine administration lowered fat mass and plasma lipid profile in HFD-induced obese mice without affecting body weight. In addition, spermidine attenuated hepatic steatosis by regulating lipid metabolism and enhancing antioxidant capacity. Moreover, spermidine reduced adipose tissue inflammation by decreasing inflammatory cytokine and chemokines expression, and these results might contributed to the enhanced thermogenic gene expression in brown adipose tissue. Furthermore, spermidine treatment enhanced gut barrier function by up-regulating tight junction- and mucin-related gene expression.
   Significance: Spermidine-mediated protective impacts involve the regulation of lipid metabolism, inflammation response, gut barrier function and thermogenesis. These findings demonstrate that spermidine has potentials in treating obesity.
C1 [Ma, Lingyan; Ni, Yinhua; Hu, Luting; Zhao, Yufeng; Zheng, Liujie; Yang, Song; Ni, Liyang; Fu, Zhengwei] Zhejiang Univ Technol, Coll Biotechnol & Bioengn, 6 Dist, Hangzhou 310032, Zhejiang, Peoples R China.
C3 Zhejiang University of Technology
RP Ni, YH; Fu, ZW (corresponding author), Zhejiang Univ Technol, Coll Biotechnol & Bioengn, 6 Dist, Hangzhou 310032, Zhejiang, Peoples R China.
EM shali0145@zjut.edu.cn; azwfu@zjut.edu.cn
RI Fu, Zhengwei/G-3162-2011; Yinhua, Ni/H-3079-2015
OI Fu, Zhengwei/0000-0003-3351-3075; NI, Liyang/0000-0002-1301-5071;
   Yinhua, Ni/0000-0001-7738-5971
FU Program for Changjiang Scholars and Innovative Research Team in
   University [IRT_17R97]
FX This research was supported by the Program for Changjiang Scholars and
   Innovative Research Team in University (No. IRT_17R97) (F.Z.).
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NR 61
TC 43
Z9 45
U1 5
U2 40
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0024-3205
EI 1879-0631
J9 LIFE SCI
JI Life Sci.
PD JAN 15
PY 2021
VL 265
AR 118739
DI 10.1016/j.lfs.2020.118739
PG 10
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA PN4DK
UT WOS:000604430800008
PM 33186567
DA 2025-06-11
ER

PT J
AU Ward, RE
   Benninghoff, AD
   Hintze, KJ
AF Ward, Robert E.
   Benninghoff, Abby D.
   Hintze, Korry J.
TI Food matrix and the microbiome: considerations for preclinical chronic
   disease studies
SO NUTRITION RESEARCH
LA English
DT Review
ID MAILLARD REACTION-PRODUCTS; CORONARY-HEART-DISEASE; GLYCATION
   END-PRODUCTS; DIETARY FIBER; GUT MICROBIOTA; OXIDATIVE STRESS;
   INSULIN-RESISTANCE; DIABETES-MELLITUS; GLYCEMIC LOAD; WESTERN DIET
AB Animal models of chronic disease are continuously being refined and have evolved with the goal of increasing the translation of results to human populations. Examples of this progress include transgenic models and germ-free animals conventionalized with human microbiota. The gut microbiome is involved in the etiology of several chronic diseases. Therefore, consideration of the experimental conditions that may affect the gut microbiome in preclinical disease is very important. Of note, diet plays a large role in shaping the gut microbiome and can be a source of variation between animal models and human populations. Traditionally, nutrition researchers have focused on manipulating the macronutrient profile of experimental diets to model diseases such as metabolic syndrome. However, other dietary components found in human foods, but not in animal diets, can have sizable effects on the composition and metabolic capacity of the gut microbiome and, as a consequence, manifestation of the chronic disease being modeled. The purpose of this review is to describe how food matrix food components, including diverse fiber sources, oxidation products from cooking, and dietary fat emulsifiers, shape the composition of the gut microbiome and influence gut health. (C) 2020 Elsevier Inc.
C1 [Ward, Robert E.; Hintze, Korry J.] Utah State Univ, Dept Nutr Dietet & Food Sci, 8700 Old Main Hill, Logan, UT 84322 USA.
   [Benninghoff, Abby D.] Utah State Univ, Dept Anim Dairy & Vet Sci, 4800 Old Main Hill, Logan, UT 84322 USA.
C3 Utah System of Higher Education; Utah State University; Utah System of
   Higher Education; Utah State University
RP Hintze, KJ (corresponding author), Utah State Univ, Dept Nutr Dietet & Food Sci, 8700 Old Main Hill, Logan, UT 84322 USA.
EM Korry.Hintze@usu.edu
RI Ward, Robert/E-1250-2011; Hintze, Korry/E-4619-2011; Benninghoff,
   Abby/AAK-6775-2020
OI Hintze, Korry/0000-0003-0135-0478; Benninghoff, Abby/0000-0002-7993-0117
FU Utah Agricultural Experiment Station [1205]
FX The authors wish to acknowledge the Utah Agricultural Experiment Station
   (Project 1205) for funding this work. All authors of this work declare
   no conflict of interest.
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NR 87
TC 17
Z9 18
U1 3
U2 14
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0271-5317
EI 1879-0739
J9 NUTR RES
JI Nutr. Res.
PD JUN
PY 2020
VL 78
BP 1
EP 10
DI 10.1016/j.nutres.2020.02.012
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA MK1BO
UT WOS:000548521400001
PM 32247914
OA hybrid
DA 2025-06-11
ER

PT J
AU Pradas, I
   Rovira-Llopis, S
   Naudi, A
   Bañuls, C
   Rocha, M
   Hernandez-Mijares, A
   Pamplona, R
   Victor, VM
   Jové, M
AF Pradas, Irene
   Rovira-Llopis, Susana
   Naudi, Alba
   Banuls, Celia
   Rocha, Milagros
   Hernandez-Mijares, Antonio
   Pamplona, Reinald
   Victor, Victor M.
   Jove, Mariona
TI Metformin induces lipid changes on sphingolipid species and oxidized
   lipids in polycystic ovary syndrome women
SO SCIENTIFIC REPORTS
LA English
DT Article
ID INSULIN-RESISTANCE; METABOLIC SYNDROME; ENDOPLASMIC-RETICULUM;
   DIAGNOSTIC-CRITERIA; RISK; PREVALENCE; PLASMA; PREDICTORS; LEUKOCYTES;
   ETIOLOGY
AB Metformin is one of the treatments used for PCOS pathology decreasing body weight, plasma androgen, FSH and glucose levels. Unfortunately, there is little known about metformin's effects on lipid metabolism, a crucial process in PCOS pathology. We have employed a lipidomic approach to explore alterations in the plasma lipid profile of patients with PCOS following metformin treatment. The aim is to offer new insights about the effect of metformin in PCOS patients. Plasma samples were obtained from 27 subjects prior to and following 12 weeks of metformin treatment. A detailed biochemical characterization and lipidomic profile was performed. Metformin reduces BMI, HOMA-IR, FSH and androstenedione and increases DHEA-S but no changes were found in glucose levels after treatment. Multivariate statistics revealed a specific lipidomic signature due to the effect of 12 weeks of metformin treatment in PCOS patients. This signature includes changes in sphingolipid metabolism suggesting a crosstalk between these lipid species and the androgenic metabolism and a decrease in oxidized lipids reinforcing that metformin treatment improves oxidative stress status. Our study confirms the specific effect of metformin in lipid metabolism on women with PCOS after 12 weeks of treatment.
C1 [Pradas, Irene; Naudi, Alba; Pamplona, Reinald; Jove, Mariona] Lleida Univ, Dept Expt Med, Inst Res Biomed Lleida UdL IRBLleida, Lleida 25198, Spain.
   [Rovira-Llopis, Susana; Banuls, Celia; Rocha, Milagros; Hernandez-Mijares, Antonio; Victor, Victor M.] Univ Hosp Dr Peset, Serv Endocrinol, Fdn Promot Healthcare & Biomed Res Valencian Comm, Valencia 46017, Spain.
   [Hernandez-Mijares, Antonio] Univ Valencia, Fdn Invest Hosp Clin Univ INCLIVA, Valencia 46010, Spain.
   [Hernandez-Mijares, Antonio] Univ Valencia, Dept Med, Valencia 46010, Spain.
   [Victor, Victor M.] Univ Valencia, Dept Physiol, Valencia 46010, Spain.
C3 Institut de Recerca Biomedica - IRB Lleida; Universitat de Lleida;
   University of Valencia; University of Valencia; University of Valencia
RP Jové, M (corresponding author), Lleida Univ, Dept Expt Med, Inst Res Biomed Lleida UdL IRBLleida, Lleida 25198, Spain.; Victor, VM (corresponding author), Univ Hosp Dr Peset, Serv Endocrinol, Fdn Promot Healthcare & Biomed Res Valencian Comm, Valencia 46017, Spain.; Victor, VM (corresponding author), Univ Valencia, Dept Physiol, Valencia 46010, Spain.
EM victor.victor@uv.es
RI VICTOR, VICTOR/I-3270-2015; Pradas, Irene/AAC-2992-2020; Naudí,
   Alba/B-5594-2009; Rovira-Llopis, Susana/AAX-8666-2021; Rocha,
   Milagros/I-4987-2015; Jove, Mariona/M-9104-2016; Pamplona,
   Reinald/A-7359-2010
OI Rovira-Llopis, Susana/0000-0002-8476-5128; Pradas,
   Irene/0000-0001-8069-7298; Rocha, Milagros/0000-0003-2923-6546; Jove,
   Mariona/0000-0001-5577-6162; Pamplona, Reinald/0000-0003-4337-6107
FU Carlos III Health Institute (ISCIII) [PI16/1083, PI16/0301]; CIBERehd
   initiatives of the ISCIII [CB06/04/0071]; European Regional Development
   Fund (ERDF "A way to build Europe"); Menarini S.A; Ministry of Health of
   the Valencian Regional Government [CES10/030]; Carlos III Health
   Institute [CP10/0360]; Spanish Ministry of Economy and Competitiveness,
   Institute of Health Carlos III [PI14/00328]; Spanish Ministry of
   Science, Innovation and Universities [RTI2018-099200-B-I00]; Generalitat
   of Catalonia, Department of Health [SLT002/16/00250]; Generalitat of
   Catalonia, Department of Business and Knowledge [2017SGR696]; FEDER
   funds from the European Union ('A way to build Europe'); Lleida
   University; Juan de la Cierva contract from Spanish Ministry of Economy
   and Competitiveness [FJCI-2015-25040]; Institute of Health Carlos III
   [CD14/00043]
FX We thank Maria Rosa Gomez and David Argiles for technical support. This
   research was funded by grants from Carlos III Health Institute (ISCIII)
   (PI16/1083, PI16/0301) to V.M.V and M.R, respectively and CIBERehd
   (CB06/04/0071)-initiatives of the ISCIII to M.R and V.M.V, the European
   Regional Development Fund (ERDF "A way to build Europe"). Unrestricted
   grant from Menarini S.A to M.R. V.M.V. and M.R. are recipients of
   contracts from the Ministry of Health of the Valencian Regional
   Government and Carlos III Health Institute (CES10/030 and CP10/0360,
   respectively). R. P. is recipient of contracts from the Spanish Ministry
   of Economy and Competitiveness, Institute of Health Carlos III (grant
   number PI14/00328); Spanish Ministry of Science, Innovation and
   Universities (grant number RTI2018-099200-B-I00), and the Generalitat of
   Catalonia, Department of Health (grant number SLT002/16/00250) and
   Department of Business and Knowledge (grant number 2017SGR696). This
   study has been co-financed by FEDER funds from the European Union ('A
   way to build Europe'). I.P. received a predoctoral fellowship from the
   Lleida University. S.R-LL. is recipient of a Juan de la Cierva contract
   from Spanish Ministry of Economy and Competitiveness (FJCI-2015-25040).
   C.B. is recipient of a Sara Borrell contract from Institute of Health
   Carlos III (CD14/00043). M.J is a Serra Hunter Fellow.
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NR 59
TC 28
Z9 29
U1 1
U2 21
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD NOV 5
PY 2019
VL 9
AR 16033
DI 10.1038/s41598-019-52263-w
PG 11
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA JJ6IS
UT WOS:000494258500053
PM 31690730
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Yao, ZY
   Chen, WB
   Shao, SS
   Ma, SZ
   Yang, CB
   Li, MZ
   Zhao, JJ
   Gao, L
AF Yao, Zhen-yu
   Chen, Wen-bin
   Shao, Shan-shan
   Ma, Shi-zhan
   Yang, Chong-bo
   Li, Meng-zhu
   Zhao, Jia-jun
   Gao, Ling
TI Role of exosome-associated microRNA in diagnostic and therapeutic
   applications to metabolic disorders
SO JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
LA English
DT Review
DE Metabolic disorders; Exosome; Exosome-associated microRNA; Non-alcoholic
   fatty liver disease; Obesity; Diabetes mellitus
ID EXTRACELLULAR VESICLES; ENDOTHELIAL-CELLS; PROTEOMIC ANALYSIS; MEDIATED
   TRANSFER; URINARY EXOSOMES; INDUCE APOPTOSIS; DENDRITIC CELLS;
   T-LYMPHOCYTES; B-LYMPHOCYTES; IN-VIVO
AB Metabolic disorders are classified clinically as a complex and varied group of diseases including metabolic syndrome, obesity, and diabetes mellitus. Fat toxicity, chronic inflammation, and oxidative stress, which may change cellular functions, are considered to play an essential role in the pathogenetic progress of metabolic disorders. Recent studies have found that cells secrete nanoscale vesicles containing proteins, lipids, nucleic acids, and membrane receptors, which mediate signal transduction and material transport to neighboring and distant cells. Exosomes, one type of such vesicles, are reported to participate in multiple pathological processes including tumor metastasis, atherosclerosis, chronic inflammation, and insulin resistance. Research on exosomes has focused mainly on the proteins they contain, but recently the function of exosome-associated microRNA has drawn a lot of attention. Exosomeassociated microRNAs regulate the physiological function and pathological processes of metabolic disorders. They may also be useful as novel diagnostics and therapeutics given their special features of non-immunogenicity and quick extraction. In this paper, we summarize the structure, content, and functions of exosomes and the potential diagnostic and therapeutic applications of exosome-associated microRNAs in the treatment of metabolic disorders.
C1 [Yao, Zhen-yu; Shao, Shan-shan; Ma, Shi-zhan; Yang, Chong-bo; Li, Meng-zhu; Zhao, Jia-jun] Shandong Univ, Inst Endocrinol & Metab, Shandong Key Lab Endocrinol & Lipid Metab, Dept Endocrinol,Shandong Acad Clin Med,Shandong P, Jinan 250021, Shandong, Peoples R China.
   [Chen, Wen-bin; Gao, Ling] Shandong Univ, Ctr Sci, Shandong Prov Hosp, Jinan 250021, Shandong, Peoples R China.
C3 Shandong University; Shandong First Medical University & Shandong
   Academy of Medical Sciences; Shandong University
RP Gao, L (corresponding author), Shandong Univ, Ctr Sci, Shandong Prov Hosp, Jinan 250021, Shandong, Peoples R China.
EM gaoling1@medmail.com.cn
RI Ma, Shizhan/HTM-6080-2023; Zhao, Jiajun/W-2963-2018; shao,
   shanshan/W-2951-2018
OI shao, shanshan/0000-0002-7759-3938; Yao, Zhen Yu/0000-0002-0616-8037;
   Ma, Shizhan/0000-0002-0506-6557; Yang, Chongbo/0000-0003-2277-8473;
   Zhao, Jiajun/0000-0003-3267-9292
FU National Natural Science Foundation of China [81230018, 81430020,
   81270869, 81670796, 81500595]
FX Project supported by the National Natural Science Foundation of China
   (Nos. 81230018, 81430020, 81270869, 81670796, and 81500595)
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NR 103
TC 41
Z9 48
U1 2
U2 102
PU ZHEJIANG UNIV
PI HANGZHOU
PA EDITORIAL BOARD, 20 YUGU RD, HANGZHOU, 310027, PEOPLES R CHINA
SN 1673-1581
EI 1862-1783
J9 J ZHEJIANG UNIV-SC B
JI J. Zhejiang Univ.-SCI. B
PD MAR
PY 2018
VL 19
IS 3
BP 183
EP 198
DI 10.1631/jzus.B1600490
PG 16
WC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
   Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
   Research & Experimental Medicine
GA FZ6SC
UT WOS:000427728800002
PM 29504312
OA Green Published
DA 2025-06-11
ER

PT J
AU Zhu, XP
   Bian, H
   Gao, X
AF Zhu, Xiaopeng
   Bian, Hua
   Gao, Xin
TI The Potential Mechanisms of Berberine in the Treatment of Nonalcoholic
   Fatty Liver Disease
SO MOLECULES
LA English
DT Review
DE berberine; nonalcoholic fatty liver disease; mechanism; insulin
   resistance; adenosine monophosphate-activated protein kinase
ID ACTIVATED PROTEIN-KINASE; HEP G2 CELLS; INSULIN-RESISTANCE; UNCOUPLING
   PROTEIN-2; METABOLIC SYNDROME; MESSENGER-RNA; UNITED-STATES;
   HEPATOCELLULAR-CARCINOMA; CONTROLLED-TRIAL; UPSTREAM KINASE
AB Nonalcoholic fatty liver disease (NAFLD) is a globally observed metabolic disease with high prevalence both in adults and children. However, there is no efficient medication available yet. Increased evidence indicates that berberine (BBR), a natural plant product, has beneficial effects on NAFLD, though the mechanisms are not completely known. In this review, we briefly summarize the pathogenesis of NAFLD and factors that influence the progression of NAFLD, and focus on the potential mechanisms of BBR in the treatment of NAFLD. Increase of insulin sensitivity, regulation of adenosine monophosphate-activated protein kinase (AMPK) pathway, improvement of mitochondrial function, alleviation of oxidative stress, LDLR mRNA stabilization, and regulation of gut microenvironment are the major targets of BBR in the treatment of NAFLD. Additionally, reduction of proprotein convertase subtilisin/kexin 9 (PCSK9) expression and DNA methylation are also involved in pharmacological mechanisms of berberine in the treatment of NAFLD. The immunologic mechanism of BBR in the treatment of NAFLD, development of berberine derivative, drug combinations, delivery routes, and drug dose can be considered in the future research.
C1 [Zhu, Xiaopeng; Bian, Hua; Gao, Xin] Fudan Univ, Zhongshan Hosp, Dept Endocrinol & Metab, Shanghai 200032, Peoples R China.
   [Zhu, Xiaopeng; Bian, Hua; Gao, Xin] Fudan Univ, Inst Metab Dis, Shanghai 200032, Peoples R China.
C3 Fudan University; Fudan University
RP Bian, H (corresponding author), Fudan Univ, Zhongshan Hosp, Dept Endocrinol & Metab, Shanghai 200032, Peoples R China.; Bian, H (corresponding author), Fudan Univ, Inst Metab Dis, Shanghai 200032, Peoples R China.
EM zhuxp200@foxmail.com; bianhuaer@126.com; zhongshan_endo@126.com
RI 欣, 高/KIJ-6255-2024
OI Gao, Xin/0000-0003-1864-7796; Bian, Hua/0000-0001-8449-0665; Zhu,
   Xiaopeng/0000-0002-1448-8743
FU National Natural Science Foundation of China [81471073]; Shanghai
   Science and Technology Committee [13441900303]; Zhongshan Hospital Fudan
   University [2015ZSYXGG15]
FX The authors thank the financial support of National Natural Science
   Foundation of China (81471073), Shanghai Science and Technology
   Committee (13441900303) and Excellent Member Program of Zhongshan
   Hospital Fudan University (2015ZSYXGG15).
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NR 86
TC 44
Z9 48
U1 1
U2 31
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1420-3049
J9 MOLECULES
JI Molecules
PD OCT
PY 2016
VL 21
IS 10
AR 1336
DI 10.3390/molecules21101336
PG 12
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA EE9AL
UT WOS:000389917900073
PM 27754444
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Suzuki-Kemuriyama, N
   Matsuzaka, T
   Kuba, M
   Ohno, H
   Han, S
   Takeuchi, Y
   Isaka, M
   Kobayashi, K
   Iwasaki, H
   Yatoh, S
   Suzuki, H
   Miyajima, K
   Nakae, D
   Yahagi, N
   Nakagawa, Y
   Sone, H
   Yamada, N
   Shimano, H
AF Suzuki-Kemuriyama, Noriko
   Matsuzaka, Takashi
   Kuba, Motoko
   Ohno, Hiroshi
   Han, Song-iee
   Takeuchi, Yoshinori
   Isaka, Masaaki
   Kobayashi, Kazuto
   Iwasaki, Hitoshi
   Yatoh, Shigeru
   Suzuki, Hiroaki
   Miyajima, Katsuhiro
   Nakae, Dai
   Yahagi, Naoya
   Nakagawa, Yoshimi
   Sone, Hirohito
   Yamada, Nobuhiro
   Shimano, Hitoshi
TI Different Effects of Eicosapentaenoic and Docosahexaenoic Acids on
   Atherogenic High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease in
   Mice
SO PLOS ONE
LA English
DT Article
ID ELEMENT-BINDING PROTEIN-1; HEPATIC STEATOSIS; OXIDATIVE STRESS; CRUCIAL
   ROLE; STEATOHEPATITIS; INFLAMMATION; N-3; OBESITY; PROSTAGLANDINS;
   TRIGLYCERIDES
AB Non-alcoholic fatty liver disease (NAFLD), the hepatic manifestation of metabolic syndrome, can progress to steatohepatitis (NASH) and advanced liver damage, such as that from liver cirrhosis and cancer. Recent studies have shown the benefits of consuming n-3 polyunsaturated fatty acids (PUFAs) for the treatment of NAFLD. In the present study, we investigated and compared the effects of the major n-3 PUFAs-eicosapentaenoic acid (EPA, C20:5) and docosahexaenoic acid (DHA, C22:6)-in preventing atherogenic high-fat (AHF) diet-induced NAFLD. Mice were fed the AHF diet supplemented with or without EPA or DHA for four weeks. Both EPA and DHA reduced the pathological features of AHF dietinduced NASH pathologies such as hepatic lobular inflammation and elevated serum transaminase activity. Intriguingly, EPA had a greater hepatic triacylglycerol (TG)-reducing effect than DHA. In contrast, DHA had a greater suppressive effect than EPA on AHF diet-induced hepatic inflammation and ROS generation, but no difference in fibrosis. Both EPA and DHA could be effective for treatment of NAFLD and NASH. Meanwhile, the two major n-3 polyunsaturated fatty acids might differ in a relative contribution to pathological intermediate steps towards liver fibrosis.
C1 [Suzuki-Kemuriyama, Noriko; Matsuzaka, Takashi; Kuba, Motoko; Ohno, Hiroshi; Han, Song-iee; Takeuchi, Yoshinori; Isaka, Masaaki; Kobayashi, Kazuto; Iwasaki, Hitoshi; Yatoh, Shigeru; Suzuki, Hiroaki; Yahagi, Naoya; Nakagawa, Yoshimi; Yamada, Nobuhiro; Shimano, Hitoshi] Univ Tsukuba, Dept Internal Med Endocrinol & Metab, Fac Med, 1-1-1 Tennodai, Tsukuba, Ibaraki 3058575, Japan.
   [Suzuki-Kemuriyama, Noriko; Miyajima, Katsuhiro; Nakae, Dai] Tokyo Univ Agr, Fac Appl Biosci, Dept Nutr Sci & Food Safety, Setagaya Ku, 1-1-1 Sakuragaoka, Tokyo 1568502, Japan.
   [Nakagawa, Yoshimi; Shimano, Hitoshi] Univ Tsukuba, Int Inst Integrat Sleep Med WPI IIIS, 1-1-1 Tennodai, Tsukuba, Ibaraki 3058575, Japan.
   [Sone, Hirohito] Niigata Univ, Dept Internal Med, Fac Med, 1-754 Asahimachi, Niigata 9518510, Japan.
   [Shimano, Hitoshi] Japan Agcy Med Res & Dev AMED, AMED CREST, Chiyoda Ku, 1-7-1 Ohte Machi, Tokyo 1000004, Japan.
C3 University of Tsukuba; Tokyo University of Agriculture; University of
   Tsukuba; Niigata University
RP Shimano, H (corresponding author), Univ Tsukuba, Dept Internal Med Endocrinol & Metab, Fac Med, 1-1-1 Tennodai, Tsukuba, Ibaraki 3058575, Japan.; Shimano, H (corresponding author), Univ Tsukuba, Int Inst Integrat Sleep Med WPI IIIS, 1-1-1 Tennodai, Tsukuba, Ibaraki 3058575, Japan.; Shimano, H (corresponding author), Japan Agcy Med Res & Dev AMED, AMED CREST, Chiyoda Ku, 1-7-1 Ohte Machi, Tokyo 1000004, Japan.
EM hshimano@md.tsukuba.ac.jp
RI Shimano, Hitoshi/V-1761-2019; Isaka, Masaaki/HTP-9469-2023; Sone,
   Hirohito/ABC-9346-2021; Yahagi, Naoya/D-2360-2014
OI Sone, Hirohito/0000-0003-1263-2817; Yahagi, Naoya/0000-0002-1823-1865;
   Shimano, Hitoshi/0000-0002-5562-5572
FU Ministry of Science, Education, Culture, and Technology of Japan
   [22117502, 15H03093]; Mochida Pharmaceutical Co. Ltd.; Grants-in-Aid for
   Scientific Research [16K13040, 16J00187, 15H03093, 15H03092, 22117502]
   Funding Source: KAKEN
FX This work was supported by Grants-in-Aid for Scientific Research
   22117502 (to H.S.), 15H03093 (to T.M.), and Program to Disseminate
   Tenure Tracking System (to T.M.) from the Ministry of Science,
   Education, Culture, and Technology of Japan. This work was also
   supported in part by Mochida Pharmaceutical Co. Ltd., who also provided
   highly purified EPA ethyl ester. Co-author Hiroyuki Kawano and Masanori
   Nakakuki are employed by Mochida Pharmaceutical Co. Ltd. Mochida
   Pharmaceutical Co. Ltd. provided support in the form of salary for
   Hiroyuki Kawano and Masanori Nakakuki, but had no additional role in
   study design, data collection and analysis, decision to publish, or
   preparation of the manuscript.
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NR 54
TC 51
Z9 54
U1 0
U2 23
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JUN 22
PY 2016
VL 11
IS 6
AR e0157580
DI 10.1371/journal.pone.0157580
PG 19
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA DP0WX
UT WOS:000378212800037
PM 27333187
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Suneja, M
   Kumar, AB
AF Suneja, Manish
   Kumar, Avinash B.
TI Obesity and perioperative acute kidney injury: A focused review
SO JOURNAL OF CRITICAL CARE
LA English
DT Review
DE Obesity; Acute kidney injury; BMI; Perioperative outcomes
ID BODY-MASS-INDEX; NONCARDIAC SURGERY; CARDIAC-SURGERY; INTRAABDOMINAL
   FAT; METABOLIC SYNDROME; BARIATRIC SURGERY; OXIDATIVE STRESS; GASTRIC
   BYPASS; RENAL-FUNCTION; OUTCOMES
AB Obesity has reached epidemic proportions in the developed world today. Obesity is a significant risk factor for cardiovascular disease, hypertension, diabetes mellitus, and chronic kidney disease. There has been renewed interest in the role of perioperative renal dysfunction with the establishment of new diagnostic criteria for kidney dysfunction such as the Acute Kidney Injury Network criteria and the Risk-Injury-Failure-Loss End-stage kidney disease criteria.
   There is increasing evidence pointing to the role of visceral adipose tissue and adipokines in the pathophysiology of obesity. Furthermore, the traditional methods of quantifying obesity such as body mass index are increasing being questioned because they may not accurately reflect true visceral obesity and may skew epidemiologic classification of metabolically healthy patients. Recent epidemiologic studies suggest the existence of an obesity paradox wherein obese patients seem to have superior perioperative outcomes compared with patients with normal and low body mass index. We seek to review the epidemiologic and pathophysiologic aspects of obesity, especially with respect to structural and functional changes in kidney function and their impact on perioperative outcomes. (C) 2014 Elsevier Inc. All rights reserved.
C1 [Suneja, Manish] Univ Iowa Hosp & Clin, Dept Nephrol, Iowa City, IA 52242 USA.
   [Kumar, Avinash B.] Vanderbilt Univ, Dept Anesthesia, Div Crit Care, Nashville, TN 37212 USA.
C3 University of Iowa; Vanderbilt University
RP Kumar, AB (corresponding author), Vanderbilt Univ, Dept Anesthesia, Nashville, TN 37212 USA.
EM manish-suneja@uiowa.edu; avinash.b.kumar@vanderbilt.edu
OI Suneja, Manish/0000-0002-1613-8456; Kumar, Avinash B/0000-0003-3970-1974
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U1 0
U2 11
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0883-9441
EI 1557-8615
J9 J CRIT CARE
JI J. Crit. Care
PD AUG
PY 2014
VL 29
IS 4
AR 694.e1
DI 10.1016/j.jcrc.2014.02.021
PG 6
WC Critical Care Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA AK1XS
UT WOS:000338213200009
PM 24666959
DA 2025-06-11
ER

PT J
AU Kagawa, Y
AF Kagawa, Yasuo
TI From clock genes to telomeres in the regulation of the healthspan
SO NUTRITION REVIEWS
LA English
DT Review
DE biological clock; circadian rhythm; lifespan; reactive oxygen species;
   telomere
ID CIRCADIAN CLOCK; OXIDATIVE STRESS; INSULIN SENSITIVITY; CALORIC
   RESTRICTION; CELLULAR SENESCENCE; METABOLIC SYNDROME; SLEEP DURATION;
   ATP SYNTHASE; LIFE-SPAN; IN-VITRO
AB Biological clocks are classified into oscillatory (clock genes) and unidirectional hourglass clocks (telomeres). Clock genes align behavioral and biochemical processes with the day/night cycle. Telomeres, the repeated series of DNA sequences that cap the ends of chromosomes, become shorter during cell division. Shortened telomeres have been documented in various pathological states associated with aging. Human activity is driven by NADH and ATP produced from nutrients, and the resulting NAD and AMP play a predominant role in energy regulation. Caloric restriction increases both AMP and NAD and is known to extend the healthspan (healthy lifespan) of animals. Silent information regulator T1 (SIRT1), the NAD-dependent deacetylase, attenuates telomere shortening, while peroxisome proliferator-activated receptor ? coactivator 1a (PGC-1a), a master modulator of gene expression, is phosphorylated by AMP kinase and deacetylated by SIRT1. Thus, PGC-1a is a key component of the circadian oscillator that integrates the mammalian clock and energy metabolism. Reactive oxygen species produced in clock mutants result in telomere shortening. The circadian rhythms produced by clock genes and lifestyle factors are ultimately controlled by the human brain and drive homeostatic and hedonic feeding and daily activity.
C1 Kagawa Nutr Univ, Dept Med Chem, Sakado, Saitama 3500288, Japan.
C3 Kagawa Nutrition University
RP Kagawa, Y (corresponding author), Kagawa Nutr Univ, Dept Med Chem, 3-9-21 Chiyoda, Sakado, Saitama 3500288, Japan.
EM kagawa@eiyo.ac.jp
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NR 78
TC 23
Z9 23
U1 0
U2 23
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0029-6643
EI 1753-4887
J9 NUTR REV
JI Nutr. Rev.
PD AUG
PY 2012
VL 70
IS 8
BP 459
EP 471
DI 10.1111/j.1753-4887.2012.00504.x
PG 13
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 980LO
UT WOS:000306894900005
PM 22835139
OA Bronze
DA 2025-06-11
ER

PT J
AU Rajesh, RV
   Kim, SK
   Park, MR
   Nam, JS
   Kim, NK
   Kwon, S
   Yoon, D
   Kim, TH
   Lee, HJ
AF Rajesh, Ramanna Valmiki
   Kim, Seong-Kon
   Park, Mi-Rim
   Nam, Jin-Seon
   Kim, Nam-Kuk
   Kwon, Seulemina
   Yoon, Duhak
   Kim, Tae-Hun
   Lee, Hyun-Jeong
TI Proteomic Functional Characterization of Bovine Stromal Vascular Cells
   from Omental, Subcutaneous and Intramuscular Adipose Depots
SO ASIAN-AUSTRALASIAN JOURNAL OF ANIMAL SCIENCES
LA English
DT Article
DE 2-DE; Stromal Vascular Cells; Adipose Depot; Proteome
ID ADIPOCYTE PRECURSOR CELLS; PROTEIN HSP70-2 GENE; TISSUE;
   DIFFERENTIATION; STRESS; RAT; EXPRESSION; INSULIN; KINASE; PROLIFERATION
AB Anatomically separate fat depots differ in size, function, and contribution to pathological states such as the metabolic syndrome. We isolated pre-adipocytes from different adipose depots, omental, subcutaneous and intramuscular, of beef cattle, and cultured in vitro to determine the basis for the variations and attribute these variations to the inherent properties of adipocyte progenitors. The proliferating cells from all depots before the confluence were harvested and the proteome was analyzed by a functional proteomic approach, involving 2-DE and MALDI-TOF/TOF. More than 252 protein spots were identified, selected and analyzed by Image Master (ver 7.0) and MALDI-TOF/TOF. Further, our analysis showed that there were specific differences in proteome expression patterns among proliferating precursor cells from the three depots. Sixteen proteins were found to be differentially expressed and these were identified as proteins involved in cellular processes, heat shock/chaperones, redox proteins, cytoskeletal proteins and metabolic enzymes. The results also enabled us to understand the basic roles of these proteins in different inherent properties exhibited by adipose tissue depots. (Key Words : 2-DE, Stromal Vascular Cells, Adipose Depot, Proteome)
C1 [Rajesh, Ramanna Valmiki; Kim, Seong-Kon; Park, Mi-Rim; Nam, Jin-Seon; Kim, Nam-Kuk; Kwon, Seulemina; Yoon, Duhak; Kim, Tae-Hun; Lee, Hyun-Jeong] Rural Dev Adm, Natl Inst Anim Sci, Div Anim Genom & Bioinformat, Suwon, South Korea.
C3 National Institute of Animal Science, Republic of Korea; Rural
   Development Administration (RDA), Republic of Korea
RP Lee, HJ (corresponding author), Rural Dev Adm, Natl Inst Anim Sci, Div Anim Genom & Bioinformat, 564 Omockchun Dong, Suwon, South Korea.
EM hyunj68@korea.kr
RI Kim, Tae Hun/IXD-3897-2023; Kim, Nam Hoon/HNS-5794-2023
FU National Institute of Animal Science [200806I01011066]
FX This study was supported by the National Institute of Animal Science
   research project, "Proteomic characterization of animal adipose and
   muscle tissue in relation to growth" (Project No. 200806I01011066).
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NR 78
TC 1
Z9 1
U1 0
U2 2
PU ASIAN-AUSTRALASIAN ASSOC ANIMAL PRODUCTION SOC
PI SEOUL
PA ROOM 708 SAMMO SPOREX, 1638-32, SEOWON-DONG, GWANAK-GU, SEOUL 151-730,
   SOUTH KOREA
SN 1011-2367
EI 1976-5517
J9 ASIAN AUSTRAL J ANIM
JI Asian Australas. J. Anim. Sci.
PD JAN
PY 2011
VL 24
IS 1
BP 110
EP 124
DI 10.5713/ajas.2011.10110
PG 15
WC Agriculture, Dairy & Animal Science
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture
GA 704EM
UT WOS:000286033900014
OA gold
DA 2025-06-11
ER

PT J
AU Bruzzone, S
   Bodrato, N
   Usai, C
   Guida, L
   Moreschi, I
   Nano, R
   Antonioli, B
   Fruscione, F
   Magnone, M
   Scarfì, S
   De Flora, A
   Zocchi, E
AF Bruzzone, Santina
   Bodrato, Nicoletta
   Usai, Cesare
   Guida, Lucrezia
   Moreschi, Iliana
   Nano, Rita
   Antonioli, Barbara
   Fruscione, Floriana
   Magnone, Mirko
   Scarfi, Sonia
   De Flora, Antonio
   Zocchi, Elena
TI Abscisic Acid Is an Endogenous Stimulator of Insulin Release from Human
   Pancreatic Islets with Cyclic ADP Ribose as Second Messenger
SO JOURNAL OF BIOLOGICAL CHEMISTRY
LA English
DT Article
ID TEMPERATURE-SIGNALING CASCADE; BETA-CELLS; HUMAN GRANULOCYTES;
   CADP-RIBOSE; IN-VITRO; INFLAMMATION; RESISTANCE; SECRETION;
   HYPERGLYCEMIA; OBESITY
AB Abscisic acid (ABA) is a plant stress hormone recently identified as an endogenous pro-inflammatory cytokine in human granulocytes. Because paracrine signaling between pancreatic beta cells and inflammatory cells is increasingly recognized as a pathogenetic mechanism in the metabolic syndrome and type II diabetes, we investigated the effect of ABA on insulin secretion. Nanomolar ABA increases glucose-stimulated insulin secretion from RIN-m and INS-1 cells and from murine and human pancreatic islets. The signaling cascade triggered by ABA in insulin-releasing cells sequentially involves a pertussis toxin-sensitive G protein, cAMP overproduction, protein kinase A-mediated activation of the ADP-ribosyl cyclase CD38, and cyclic ADP-ribose overproduction. ABA is rapidly produced and released from human islets, RIN-m, and INS-1 cells stimulated with high glucose concentrations. In conclusion, ABA is an endogenous stimulator of insulin secretion in human and murine pancreatic beta cells. Autocrine release of ABA by glucose-stimulated pancreatic beta cells, and the paracrine production of the hormone by activated granulocytes and monocytes suggest that ABA may be involved in the physiology of insulin release as well as in its dysregulation under conditions of inflammation.
C1 [Bruzzone, Santina; Bodrato, Nicoletta; Guida, Lucrezia; Moreschi, Iliana; Fruscione, Floriana; Magnone, Mirko; Scarfi, Sonia; De Flora, Antonio; Zocchi, Elena] Univ Genoa, Biochem Sect, Dept Expt Med, I-16132 Genoa, Italy.
   [Bruzzone, Santina; Bodrato, Nicoletta; Guida, Lucrezia; Moreschi, Iliana; Fruscione, Floriana; Magnone, Mirko; Scarfi, Sonia; De Flora, Antonio; Zocchi, Elena] Univ Genoa, Ctr Excellence Biomed Res, I-16132 Genoa, Italy.
   [Bruzzone, Santina; Guida, Lucrezia; Fruscione, Floriana; Magnone, Mirko; Scarfi, Sonia; Zocchi, Elena] Adv Biotechnol Ctr, I-16132 Genoa, Italy.
   [Usai, Cesare] CNR, Inst Biophys, I-16149 Genoa, Italy.
   [Nano, Rita; Antonioli, Barbara] Ist Sci San Raffaele, Islet Proc Facil, I-20132 Milan, Italy.
C3 University of Genoa; University of Genoa; Consiglio Nazionale delle
   Ricerche (CNR); Istituto di Biofisica (IBF-CNR); Vita-Salute San
   Raffaele University; IRCCS Ospedale San Raffaele
RP Zocchi, E (corresponding author), Univ Genoa, Biochem Sect, Dept Expt Med, Viale Benedetto XV 1, I-16132 Genoa, Italy.
EM ezocchi@unige.it
RI Scarfi, Sonia/AAJ-2387-2020; Nano, Rita/AAC-1934-2019; fruscione,
   floriana/HJZ-2126-2023; Bruzzone, Santina/A-4264-2015
OI R, Nano/0000-0003-4520-8481; fruscione, floriana/0000-0002-4054-645X;
   Scarfi, Sonia/0000-0002-7079-6919; Bruzzone,
   Santina/0000-0003-2034-3716; Usai, Cesare/0000-0001-8863-7759
FU Associazione Italiana per la Ricerca sul Cancro; Italian Ministry of
   Education, University and Scientific Research [MIUR-PRIN 2005, MIUR FIRB
   RBAUO19A3C, MIUR FIRB RBNE01ERXR, MIUR FIRB RBLA039LSF, MIUR FIRB
   RBIP06LSS2]; University of Genova and Fondazione Cassa di Risparmio di
   Genova e Imperia
FX This work was supported in part by grants from Regione Liguria, from the
   Associazione Italiana per la Ricerca sul Cancro, from the Italian
   Ministry of Education, University and Scientific Research Grants
   MIUR-PRIN 2005, MIUR FIRB RBAUO19A3C, MIUR FIRB RBNE01ERXR, MIUR FIRB
   RBLA039LSF, and MIUR FIRB RBIP06LSS2, and the University of Genova and
   Fondazione Cassa di Risparmio di Genova e Imperia. The costs of
   publication of this article were defrayed in part by the payment of page
   charges. This article must therefore be hereby marked "advertisement" in
   accordance with 18 U. S. C. Section 1734 solely to indicate this fact.
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   ZOCCHI E, 2006, FLURIDONE ANTIN 1006
NR 42
TC 125
Z9 139
U1 2
U2 17
PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
PI ROCKVILLE
PA 11200 ROCKVILLE PIKE, SUITE 302, ROCKVILLE, MD, UNITED STATES
SN 0021-9258
EI 1083-351X
J9 J BIOL CHEM
JI J. Biol. Chem.
PD NOV 21
PY 2008
VL 283
IS 47
BP 32188
EP 32197
DI 10.1074/jbc.M802603200
PG 10
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 372HW
UT WOS:000260893700005
PM 18784081
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Wang, XW
   Chai, H
   Yao, QZ
   Chen, CY
AF Wang, Xinwen
   Chai, Hong
   Yao, Qizhi
   Chen, Changyi
TI Molecular mechanisms of HIV protease inhibitor-induced endothelial
   dysfunction
SO JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
LA English
DT Review
DE endothelial dysfunction; endothelium-dependent vasorelaxation; HIV
   protease inhibitor; nitric oxide synthase; reactive oxygen species
ID CORONARY-HEART-DISEASE; INDUCED VASCULAR DYSFUNCTION; INTIMA-MEDIA
   THICKNESS; NITRIC-OXIDE SYNTHASE; INSULIN-RESISTANCE; INFECTED PATIENTS;
   CARDIOVASCULAR-DISEASE; PGC-1 COACTIVATORS; RISK-FACTORS; RITONAVIR
AB Highly active antiretroviral therapy incorporating protease inhibitors (PIs) is successful in controlling HIV infection and has dramatically improved the prognosis of HIV infected patients. The therapeutic benefit of long-tern use of HIV Pis is compromised by an increased risk of cardiovascular disease, however, including metabolic syndrome and endothelial dysfunction. Although clinical evidence strongly suggests an association of the use of HIV Pis with endothelial dysfunction, the underlying molecular mechanisms have not been fully elucidated yet. In this review, we describe recent advances in the molecular mechanisms of PI-induced endothelial dysfunction. The available evidence demonstrates that certain HIV Pis could induce endothelial dysfunction, including a decrease of endothelium-dependent vasorelaxation, inhibition of the nitric oxide synthase system, increase of oxidative stress, and activation of mitogen-activated protein kinases. HIV infection itself may also induce endothelial dysfunction and injury. These new discoveries provide a better understanding of the molecular mechanisms of the interaction between HIV Pis and vascular cells and may suggest potential approaches to control HIV PI-associated cardiovascular complications.
C1 Baylor Coll Med, Michael E DeBakey Dept Surg, Mol Surg Res Ctr, Div Vas Surg & Endovasc Therapy, Houston, TX 77030 USA.
C3 Baylor College of Medicine
RP Chen, CY (corresponding author), Baylor Coll Med, Michael E DeBakey Dept Surg, Mol Surg Res Ctr, Div Vas Surg & Endovasc Therapy, 1 Baylor Plaza,Mailstop NAB-2010, Houston, TX 77030 USA.
EM jchen@bcm.tmc.edu
RI Chai, Hong/H-5438-2011
FU NCCIH NIH HHS [AT 003094] Funding Source: Medline; NHLBI NIH HHS [HL
   083471, HL 072716, HL 065916] Funding Source: Medline; NIBIB NIH HHS [EB
   002436] Funding Source: Medline; NIDCR NIH HHS [DE 15543] Funding
   Source: Medline
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NR 84
TC 87
Z9 94
U1 0
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1525-4135
EI 1077-9450
J9 JAIDS-J ACQ IMM DEF
JI JAIDS
PD APR 15
PY 2007
VL 44
IS 5
BP 493
EP 499
DI 10.1097/QAI.0b013e3180322542
PG 7
WC Immunology; Infectious Diseases
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Infectious Diseases
GA 152YZ
UT WOS:000245399700001
PM 17245228
OA Bronze
DA 2025-06-11
ER

PT J
AU Barbalace, MC
   Talotta, R
   Rapisarda, F
   D'Amico, V
   Laganà, M
   Malaguti, M
   Campennì, A
   Cannavò, S
   Hrelia, S
   Ruggeri, RM
AF Barbalace, Maria Cristina
   Talotta, Rossella
   Rapisarda, Federica
   D'Amico, Valeria
   Lagana, Martina
   Malaguti, Marco
   Campenni, Alfredo
   Cannavo, Salvatore
   Hrelia, Silvana
   Ruggeri, Rosaria Maddalena
TI Unlocking the Power of the Mediterranean Diet: Two in One-Dual Benefits
   for Rheumatic and Thyroid Autoimmune Diseases
SO NUTRIENTS
LA English
DT Review
DE Mediterranean diet; polyphenols; polyunsaturated fatty acids (PUFAs);
   rheumatoid arthritis; spondyloarthritis; systemic lupus erythematosus;
   Sjogren's syndrome; autoimmune thyroiditis; oxidative stress
ID SYSTEMIC-LUPUS-ERYTHEMATOSUS; MODERATE ALCOHOL-CONSUMPTION;
   FIBROBLAST-LIKE SYNOVIOCYTES; POLYUNSATURATED FATTY-ACIDS; VITAMIN-D
   LEVELS; METABOLIC SYNDROME; OLIVE OIL; CLASSIFICATION CRITERIA;
   SJOGRENS-SYNDROME; FISH-OIL
AB In recent years, autoimmune diseases are becoming more and more prevalent worldwide, with this rapid rise being influenced by environmental factors linked to lifestyle changes in modern societies. In this context, the role of diet has been the topic of extensive research as evidence has mounted that particular dietary patterns may contribute to or modulate autoimmunity. The present review specifically focuses on the Mediterranean diet (MD) as a whole dietary pattern, and on its peculiar components, such as n-3 polyunsaturated fatty acids (PUFAs), polyphenols and fiber. We explored their potential benefits in a spectrum of both systemic and organ-specific autoimmune disorders, including rheumatic diseases (like rheumatic arthritis and systemic lupus erythematosus), and thyroid diseases (like Hashimoto's thyroiditis), since they often occur in the same individuals. Here, we offer a comprehensive review about the influence of dietary factors on these autoimmune diseases and potential translation into therapeutic interventions, as an adjuvant therapeutic approach to improve autoimmunity-related outcomes.
C1 [Barbalace, Maria Cristina; Malaguti, Marco; Hrelia, Silvana] Univ Bologna, Dept Life Qual Studies, Alma Mater Studiorum, I-47921 Rimini, Italy.
   [Talotta, Rossella; Rapisarda, Federica; D'Amico, Valeria] Univ Hosp G Martino, Dept Clin & Expt Med, Rheumatol Unit, I-98124 Messina, Italy.
   [Lagana, Martina; Cannavo, Salvatore; Ruggeri, Rosaria Maddalena] Univ Messina, Dept Human Pathol Adulthood & Childhood DETEV G Ba, Endocrinol Unit, I-98125 Messina, Italy.
   [Campenni, Alfredo] Univ Messina, Dept Biomed & Dent Sci & Morpho Funct Imaging, Unit Nucl Med, I-98125 Messina, Italy.
C3 University of Bologna; AOU Policlinico Gaetano Martino; University of
   Messina; University of Messina
RP Barbalace, MC (corresponding author), Univ Bologna, Dept Life Qual Studies, Alma Mater Studiorum, I-47921 Rimini, Italy.
EM maria.barbalace2@unibo.it; rtalotta@unime.it;
   feduccia.rapisarda@gmail.com; damico.valeria95@libero.it;
   martinalagana5@gmal.com; marco.malaguti@unibo.it; acampenni@unime.it;
   cannavos@unime.it; silvana.hrelia@unibo.it; rmruggeri@unime.it
RI Malaguti, Marco/K-5994-2015; Ruggeri, Rosaria/AAB-7364-2019; Barbalace,
   Maria Cristina/GLU-3550-2022; Campennì, Alfredo/P-4067-2016
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NR 152
TC 1
Z9 1
U1 2
U2 2
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD APR 19
PY 2025
VL 17
IS 8
AR 1383
DI 10.3390/nu17081383
PG 31
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 1VG1G
UT WOS:001474466600001
PM 40284245
OA gold
DA 2025-06-11
ER

PT J
AU Azevedo-Martins, AK
   Santos, MP
   Abayomi, J
   Ferreira, NJR
   Evangelista, FS
AF Azevedo-Martins, Anna Karenina
   Santos, Matheus Pedro
   Abayomi, Julie
   Ferreira, Natalia Juliana Ramos
   Evangelista, Fabiana S.
TI The Impact of Excessive Fructose Intake on Adipose Tissue and the
   Development of Childhood Obesity
SO NUTRIENTS
LA English
DT Review
DE fructose; childhood obesity; adipose tissue
ID SUGAR-SWEETENED BEVERAGE; METABOLIC SYNDROME; DIETARY FRUCTOSE;
   LIPID-METABOLISM; GLUCOSE; EXPRESSION; FAT; INFLAMMATION; ASSOCIATION;
   GROWTH
AB Worldwide, childhood obesity cases continue to rise, and its prevalence is known to increase the risk of non-communicable diseases typically found in adults, such as cardiovascular disease and type 2 diabetes mellitus. Thus, comprehending its multiple causes to build healthier approaches and revert this scenario is urgent. Obesity development is strongly associated with high fructose intake since the excessive consumption of this highly lipogenic sugar leads to white fat accumulation and causes white adipose tissue (WAT) inflammation, oxidative stress, and dysregulated adipokine release. Unfortunately, the global consumption of fructose has increased dramatically in recent years, which is associated with the fact that fructose is not always evident to consumers, as it is commonly added as a sweetener in food and sugar-sweetened beverages (SSB). Therefore, here, we discuss the impact of excessive fructose intake on adipose tissue biology, its contribution to childhood obesity, and current strategies for reducing high fructose and/or free sugar intake. To achieve such reductions, we conclude that it is important that the population has access to reliable information about food ingredients via food labels. Consumers also need scientific education to understand potential health risks to themselves and their children.
C1 [Azevedo-Martins, Anna Karenina; Santos, Matheus Pedro; Ferreira, Natalia Juliana Ramos; Evangelista, Fabiana S.] Univ Sao Paulo, Sch Arts Sci & Humanities, Grp Study Endocrinol & Metab, BR-03828000 Sao Paulo, Brazil.
   [Abayomi, Julie] Edge Hill Univ, Sch Med & Nutr, Fac Hlth Social Care & Med, Ormskirk L39 4QP, England.
C3 Universidade de Sao Paulo; Edge Hill University
RP Azevedo-Martins, AK (corresponding author), Univ Sao Paulo, Sch Arts Sci & Humanities, Grp Study Endocrinol & Metab, BR-03828000 Sao Paulo, Brazil.
EM karenina@usp.br; rivermathe@gmail.com; abayomij@edgehill.ac.uk;
   rms.natalia@gmail.com; fabiana_evangelista@yahoo.com.br
RI Azevedo-Martins, Anna/F-4331-2016; Santos, Matheus/JUV-6904-2023;
   Evangelista, Fabiana/A-5298-2013
OI Abayomi, Julie/0000-0002-8133-5595
FU So Paulo Research Foundation
FX No Statement Available
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NR 154
TC 7
Z9 8
U1 4
U2 14
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD APR
PY 2024
VL 16
IS 7
AR 939
DI 10.3390/nu16070939
PG 19
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA NM9A8
UT WOS:001200975300001
PM 38612973
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Castro, MFV
   Assmann, CE
   Reichert, KP
   Coppetti, PM
   Stefanello, N
   da Silva, AD
   Mostardeiro, VB
   de Jesus, LB
   da Silveira, MV
   Schirmann, AA
   Fracasso, M
   Maciel, RM
   Morsch, VMM
   Schetinger, MRC
AF Castro, Milagros Fanny Vera
   Assmann, Charles Elias
   Reichert, Karine Paula
   Coppetti, Priscila Marquezan
   Stefanello, Naiara
   da Silva, Anielen Dutra
   Mostardeiro, Vitor Bastianello
   de Jesus, Loren Borba
   da Silveira, Marcylene Vieira
   Schirmann, Adriel Antonio
   Fracasso, Mateus
   Maciel, Roberto Marinho
   Morsch, Vera Maria Melchiors
   Schetinger, Maria Rosa Chitolina
TI Vitamin D3 mitigates type 2 diabetes induced by a high carbohydrate-high
   fat diet in rats: Role of the purinergic system
SO JOURNAL OF NUTRITIONAL BIOCHEMISTRY
LA English
DT Article
DE Vitamin D3; Hyperglycemia; Purinergic signaling; Oxidative stress;
   Insulin
ID SUBCELLULAR-LOCALIZATION; METABOLIC SYNDROME; RECEPTORS; PANCREAS;
   EXPRESSION; PARAMETERS; ADENOSINE; HEALTH; TARGET; GENE
AB This study evaluated the effect of vitamin D3 (VIT D3 ) supplementation on the enzymatic activities and density of ectonucleoside triphosphate diphosphohydrolase (E-NTPDase), ecto-5-nucleotidase (E -5' -NT), adenosine deaminase (ADA), as well as the density of P2 x 7R, P2Y12R, A1R, A2AR receptors, IL-1 beta, and oxidative parameters in type 2 diabetic rats. Forty male Wistar rats were fed a high carbohydrate -high fat diet (HCHFD) and received an intraperitoneal injection containing a single dose of streptozotocin (STZ, 35 mg/kg). Animals were divided into four groups: 1) control; 2) control/VIT D3 12 mu g/kg; 3) diabetic; and 4) diabetic/VIT D3 12 mu g/kg. Results show that VIT D3 reduced blood glucose, ATP hydrolysis, ADA activity, P2Y12R density (platelets), as well as ATP, ADP, and AMP hydrolysis and ADA activity (synaptosomes). Moreover, VIT D3 increased insulin levels and AMP hydrolysis (platelets) and improved antioxidant defense. Therefore, we suggest that VIT D3 treatment modulates hyperglycemia -induced changes via purinergic enzymes and receptor expression, consequently attenuating insulin homeostasis dysregulation in the diabetic state. (c) 2024 Elsevier Inc. All rights reserved.
C1 [Castro, Milagros Fanny Vera; Assmann, Charles Elias; Reichert, Karine Paula; Coppetti, Priscila Marquezan; Stefanello, Naiara; da Silva, Anielen Dutra; Mostardeiro, Vitor Bastianello; de Jesus, Loren Borba; da Silveira, Marcylene Vieira; Schirmann, Adriel Antonio; Fracasso, Mateus; Morsch, Vera Maria Melchiors; Schetinger, Maria Rosa Chitolina] Univ Fed Santa Maria, Ctr Nat & Exact Sci, Grad Program Biol Sci Toxicol Biochem, Univ Campus, Santa Maria, RS, Brazil.
   [Maciel, Roberto Marinho] Univ Fed Santa Maria, Dept Pathol, Univ Campus, Santa Maria, RS, Brazil.
   [Castro, Milagros Fanny Vera] Univ Fed Santa Maria, Univ Campus, BR-97105900 Santa Maria, RS, Brazil.
C3 Universidade Federal de Santa Maria (UFSM); Universidade Federal de
   Santa Maria (UFSM); Universidade Federal de Santa Maria (UFSM)
RP Castro, MFV (corresponding author), Univ Fed Santa Maria, Univ Campus, BR-97105900 Santa Maria, RS, Brazil.
EM mifave_11@hotmail.com; mariachitolina@gmail.com
RI Copetti, Priscila/AAS-4605-2020; Schetinger, Maria/JAC-4640-2023;
   Stefanello, Naiara/W-2137-2019; Maciel, Roberto/AAT-4873-2021; Morsch,
   Vera/M-6215-2014; Mostardeiro, Vitor/ITT-9593-2023; Assmann,
   Charles/AAM-8039-2021; Assmann, Charles/E-8936-2015
OI Vieira da Silveira, Marcylene/0000-0001-7825-3903; Vera Castro, Milagros
   Fanny/0000-0001-9274-2877; Assmann, Charles/0000-0002-3524-3446;
   Bastianello Mostardeiro, Vitor/0000-0003-4320-0400; Marquezan Copetti,
   Priscila/0000-0003-1140-6236
FU Fundacao de Amparo a Pesquisa do Estado do Rio Grande do Sul (FAPERGS);
   Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
   [304872/2018-0]; Conselho Nacional de Desenvolvimento Cientifico e
   Tecnologico (CNPq) [18/2551-0000505-3]; Universidade Federal de Santa
   Maria (UFSM);  [001]
FX The authors would like to thank (Fundacao de Amparo a Pesquisa do Estado
   do Rio Grande do Sul) , (FAPERGS; 18/2551-0000505-3) , (Coordenacao de
   Aperfeicoamento de Pessoal de Nivel Superior (CAPES; Finance Code 001) ,
   Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq;
   304872/2018-0) , and Universidade Federal de Santa Maria (UFSM) for the
   funding provided.
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NR 53
TC 0
Z9 0
U1 2
U2 6
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0955-2863
EI 1873-4847
J9 J NUTR BIOCHEM
JI J. Nutr. Biochem.
PD MAY
PY 2024
VL 127
AR 109602
DI 10.1016/j.jnutbio.2024.109602
EA MAR 2024
PG 13
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA NU1D6
UT WOS:001202867900001
PM 38373509
DA 2025-06-11
ER

PT J
AU Ibanez, A
   Northoff, G
AF Ibanez, Agustin
   Northoff, Georg
TI Intrinsic timescales and predictive allostatic interoception in brain
   health and disease
SO NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
LA English
DT Article
DE Cognitive neuroscience; Brain health; Psychiatry; Neurology; Predictive
   coding theory; Allostatic interoception; Intrinsic neural timescales;
   Spatiotemporal hierarchies; Brain dynamics; Transnosological
   explanations
ID HEART-RATE-VARIABILITY; DEFAULT-MODE NETWORK; FRONTOTEMPORAL DEMENTIA;
   METABOLIC SYNDROME; STRESS; CONNECTIVITY; METAANALYSIS; INFORMATION;
   DISORDERS; SEQUENCES
AB The cognitive neuroscience of brain diseases faces challenges in understanding the complex relationship between brain structure and function, the heterogeneity of brain phenotypes, and the lack of dimensional and transnosological explanations. This perspective offers a framework combining the predictive coding theory of allostatic interoceptive overload (PAIO) and the intrinsic neural timescales (INT) theory to provide a more dynamic understanding of brain health in psychiatry and neurology. PAIO integrates allostasis and interoception to assess the interaction between internal patterns and environmental stressors, while INT shows that different brain regions operate on different intrinsic timescales. The allostatic overload can be understood as a failure of INT, which involves a breakdown of proper temporal integration and segregation. This can lead to dimensional disbalances between exteroceptive/interoceptive inputs across brain and whole-body levels (cardiometabolic, cardiovascular, inflammatory, immune). This approach offers new insights, presenting novel perspectives on brain spatiotemporal hierarchies and interactions. By integrating these theories, the paper opens innovative paths for studying brain health dynamics, which can inform future research in brain health and disease.
C1 [Ibanez, Agustin] Univ Calif San Francisco UCSF, Global Brain Hlth Inst GBHI, San Francisco, CA USA.
   [Ibanez, Agustin] Univ Adolfo Ibanez, Latin American Brain Hlth BrainLat, Santiago, Chile.
   [Ibanez, Agustin] Univ San Andres, Cognit Neurosci Ctr CNC, Buenos Aires, Argentina.
   [Northoff, Georg] Zhejiang Univ, Sch Med, Mental Hlth Ctr, Hangzhou, Zhejiang, Peoples R China.
   [Northoff, Georg] Hangzhou Normal Univ, Affiliated Hosp, Ctr Cognit & Brain Disorders, Hangzhou, Peoples R China.
   [Northoff, Georg] Univ Ottawa, Inst Mental Hlth Res, Mind Brain Imaging & Neuroeth, Ottawa, ON, Canada.
   [Ibanez, Agustin] Trinity Coll Dublin, Dublin, Ireland.
C3 University of California System; University of California San Francisco;
   Universidad Adolfo Ibanez; Universidad de San Andres Argentina; Zhejiang
   University; Hangzhou Normal University; University of Ottawa; Trinity
   College Dublin
RP Ibanez, A (corresponding author), Univ Adolfo Ibanez, Latin American Brain Hlth BrainLat, Santiago, Chile.; Northoff, G (corresponding author), Zhejiang Univ, Sch Med, Mental Hlth Ctr, Hangzhou, Zhejiang, Peoples R China.
EM agustin.ibanez@gbhi.org; Georg.Northoff@theroyal.ca
RI Ibanez, Agustin/H-7976-2015
OI Ibanez, Agustin/0000-0001-6758-5101
FU CONICET [1210195, 1210176, 1220995, ANID/FONDAP/15150012]; CONICET;
   ANID/FONDECYT Regular [1210195, 1210176, 1220995]; ANID/PIA/ANILLOS
   [ANID/FONDAP/15150012]; FONDEF [ACT210096]; ANID/FONDAP [ID20I10152,
   ID22I10029]; Takeda [15150012]; MULTI-PARTNER CONSORTIUM TO EXPAND
   DEMENTIA RESEARCH IN LATIN AMERICA [ReDLat by Fogarty International
   Center (FIC) , National Institutes of Health, National Institutes of
   Aging] (CARDS-NIH) [CW2680521]; MULTI-PARTNER CONSORTIUM TO EXPAND
   DEMENTIA RESEARCH IN LATIN AMERICA [Alzheimer's Association] [R01
   AG057234, R01 AG075775, R01 AG21051, R01 AG083799]; MULTI-PARTNER
   CONSORTIUM TO EXPAND DEMENTIA RESEARCH IN LATIN AMERICA [Rainwater
   Charitable Foundation] [SG-20-725707]; MULTI-PARTNER CONSORTIUM TO
   EXPAND DEMENTIA RESEARCH IN LATIN AMERICA [Global Brain Health
   Institute]
FX AI is supported by grants from CONICET; ANID/FONDECYT Regular (1210195
   and 1210176 and 1220995) ; ANID/FONDAP/15150012; ANID/PIA/ANILLOS
   ACT210096; FONDEF ID20I10152, ID22I10029; ANID/FONDAP 15150012; Takeda
   CW2680521 and the MULTI-PARTNER CONSORTIUM TO EXPAND DEMENTIA RESEARCH
   IN LATIN AMERICA [ReDLat, supported by Fogarty International Center
   (FIC) , National Institutes of Health, National Institutes of Aging (R01
   AG057234, R01 AG075775, R01 AG21051, R01 AG083799, CARDS-NIH) ,
   Alzheimer's Association (SG-20-725707) , Rainwater Charitable Foundation
   - The Bluefield project to cure FTD, and Global Brain Health Institute)
   ] . GN is supported by CIHR, SHERRC, NSERC, NFRF, and the UK-Canada AI
   grant which he holds together with Karl Friston. The contents of this
   publication are solely the responsibility of the authors and do not
   represent the official views of these institutions.
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NR 150
TC 13
Z9 13
U1 4
U2 11
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0149-7634
EI 1873-7528
J9 NEUROSCI BIOBEHAV R
JI Neurosci. Biobehav. Rev.
PD FEB
PY 2024
VL 157
AR 105510
DI 10.1016/j.neubiorev.2023.105510
EA DEC 2023
PG 12
WC Behavioral Sciences; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Behavioral Sciences; Neurosciences & Neurology
GA FW8V3
UT WOS:001148990500001
PM 38104789
OA Green Accepted, hybrid
DA 2025-06-11
ER

PT J
AU Xia, LJ
   Shen, YP
   Liu, SY
   Du, J
AF Xia, Lingjin
   Shen, Yupei
   Liu, Suying
   Du, Jing
TI Iron overload triggering ECM-mediated Hippo/YAP pathway in follicle
   development: a hypothetical model endowed with therapeutic implications
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Review
DE follicle development; iron overload; ferroptosis; extracellular matrix
   (ECM); Hippo; YAP pathway
ID HUMAN OVARIAN-FOLLICLES; MEIOTIC CELL-CYCLE; TGF-BETA; OXIDATIVE STRESS;
   TRANSFERRIN RECEPTOR; SIGNALING DISRUPTION; LIPID-PEROXIDATION;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; HYDROGEN-PEROXIDE
AB Disruption of iron homeostasis plays a negative role in follicle development. The dynamic changes in follicle growth are dependent on Hippo/YAP signaling and mechanical forces. However, little is known about the liaison between iron overload and the Hippo/YAP signalling pathway in term of folliculogenesis. Here, based on the available evidence, we established a hypothesized model linking excessive iron, extracellular matrix (ECM), transforming growth factor-beta (TGF-beta) and Hippo/Yes-associated protein (YAP) signal regarding follicle development. Hypothetically, the TGF-beta signal and iron overload may play a synergistic role in ECM production via YAP. We speculate that the dynamic homeostasis of follicular iron interacts with YAP, increasing the risk of ovarian reserve loss and may enhance the sensitivity of follicles to accumulated iron. Hence, therapeutic interventions targeting iron metabolism disorders, and Hippo/YAP signal may alter the consequences of the impaired developmental process based on our hypothesis, which provides potential targets and inspiration for further drug discovery and development applied to clinical treatment.
C1 [Xia, Lingjin; Shen, Yupei; Du, Jing] Fudan Univ, Shanghai Inst Biomed & Pharmaceut Technol, Sch Pharm, Natl Hlth Commiss Peoples Republ China,NHC Key Lab, Shanghai, Peoples R China.
   [Liu, Suying] Fudan Univ, Zhongshan Hosp, Reprod Med Ctr, Shanghai, Peoples R China.
C3 Shanghai Academy of Science & Technology; Fudan University; Fudan
   University
RP Du, J (corresponding author), Fudan Univ, Shanghai Inst Biomed & Pharmaceut Technol, Sch Pharm, Natl Hlth Commiss Peoples Republ China,NHC Key Lab, Shanghai, Peoples R China.; Liu, SY (corresponding author), Fudan Univ, Zhongshan Hosp, Reprod Med Ctr, Shanghai, Peoples R China.
EM lsy6592@163.com; dujing42@126.com
RI Du, Jing/AAY-4092-2021
OI Liu, Suying/0000-0002-3148-2247
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NR 182
TC 5
Z9 6
U1 3
U2 8
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD MAY 8
PY 2023
VL 14
AR 1174817
DI 10.3389/fendo.2023.1174817
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA G8QS0
UT WOS:000991743200001
PM 37223010
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Shinozaki, Y
   Fukui, K
   Maekawa, M
   Toyoda, K
   Yoshiuchi, H
   Inagaki, K
   Uno, K
   Miyajima, K
   Ohta, T
AF Shinozaki, Yuichi
   Fukui, Kenji
   Maekawa, Mariko
   Toyoda, Kaoru
   Yoshiuchi, Hiromi
   Inagaki, Koji
   Uno, Kinuko
   Miyajima, Katsuhiro
   Ohta, Takeshi
TI Unilateral Nephrectomized SHR/NDmcr-cp Rat Shows a Progressive Decline
   of Glomerular Filtration With Tubular Interstitial Lesions
SO PHYSIOLOGICAL RESEARCH
LA English
DT Article
DE SHR/NDmcr-cp rat; Unilateral nephrectomy; Ccr decline
ID DIABETIC-NEPHROPATHY; HYPOXIA; DISEASE; STRESS
AB In patients with diabetic kidney disease (DKD), the estimated glomerular filtration rate (eGFR) or creatinine clearance rate (Ccr) is always used as an index of decline in renal function. However, there are few animal models of DKD that could be used to evaluate renal function based on GFR or Ccr. For this reason, it is desirable to develop animal models to assess renal function, which could also be used for the evaluation of novel therapeutic agents for DKD. Therefore, we aimed to develop such animal model of DKD by using spontaneously hypertensive rat (SHR)/NDmcr-cp (cp/cp) rats with the characteristics of obese type 2 diabetes and metabolic syndrome. As a result, we have found that unilateral nephrectomy (UNx) caused a chronic Ccr decline, development of glomerular sclerosis, tubular lesions, and tubulointerstitial fibrosis, accompanied by renal anemia. Moreover, losartan-mixed diet suppressed the Ccr decline in UNx-performed SHR/NDmcr-cp rats (UNx-SHR/cp rats), with improvement in renal anemia and histopathological changes. These results suggest that UNx-SHR/cp rats could be used as a DKD model for evaluating the efficacy of therapeutic agents based on suppression of renal function decline.
C1 [Shinozaki, Yuichi; Ohta, Takeshi] Kyoto Univ, Grad Sch Agr, Lab Anim Physiol & Funct Anat, Kyoto, Japan.
   [Shinozaki, Yuichi; Fukui, Kenji; Maekawa, Mariko; Yoshiuchi, Hiromi; Inagaki, Koji] Japan Tobacco Inc, Cent Pharmaceut Res Inst, Osaka, Japan.
   [Toyoda, Kaoru] Japan Tobacco Inc, Cent Pharmaceut Res Inst, Toxicol Res Labs, Yokohama, Kanagawa, Japan.
   [Maekawa, Mariko] Niigata Univ, Grad Sch Sci & Technol, Niigata, Japan.
   [Uno, Kinuko; Miyajima, Katsuhiro] Tokyo Univ Agr, Fac Appl Biosci, Dept Nutr Sci & Food Safety, Tokyo, Japan.
C3 Kyoto University; Japan Tobacco Inc.; Japan Tobacco Inc.; Niigata
   University; Tokyo University of Agriculture
RP Shinozaki, Y (corresponding author), Kyoto Univ, Grad Sch Agr, Lab Anim Physiol & Funct Anat, Kyoto 6068502, Japan.
EM shinozaki.yuichi.64s@st.kyoto-u.ac.jp
RI Yuichi, Shinozaki/AAO-5953-2021
OI tai tian, yi/0000-0002-9573-3455
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NR 32
TC 4
Z9 4
U1 1
U2 4
PU ACAD SCIENCES CZECH REPUBLIC, INST PHYSIOLOGY
PI PRAGUE 4
PA VIDENSKA 1083, PRAGUE 4 142 20, CZECH REPUBLIC
SN 0862-8408
EI 1802-9973
J9 PHYSIOL RES
JI Physiol. Res.
PD APR
PY 2023
VL 72
IS 2
BP 209
EP 220
DI 10.33549/physiolres.934969
PG 12
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA Q4GM1
UT WOS:001057117900008
PM 37159855
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Popescu, LA
   Virgolici, B
   Stefan, DCA
   Lixandru, D
   Timnea, O
   Virgolici, H
   Oraseanu, D
   Sinescu, C
   Mohora, M
AF Popescu, Laura Anca
   Virgolici, Bogdana
   Stefan, Daciana Costina Andrada
   Lixandru, Daniela
   Timnea, Olivia
   Virgolici, Horia
   Oraseanu, Dumitru
   Sinescu, Crina
   Mohora, Maria
TI Vascular Reactivity and Proinflammatory Cytokines in the Obese Children
SO REVISTA DE CHIMIE
LA English
DT Article
DE childhood obesity; FMD; inflammation
ID DENSITY-LIPOPROTEIN CHOLESTEROL; FLOW-MEDIATED DILATION; LOW-GRADE
   INFLAMMATION; ARTERIAL STIFFNESS; ENDOTHELIAL DYSFUNCTION;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; CAROTID-ARTERY; PLASMA; RISK
AB The aim of this study was to evaluate the relation between inflammatory markers and the preatherosclerotic marker- flow mediated dilation (FMD). Thirty obese children (10-16 years old) and twenty controls were involved. The plasma inflammatory markers: CRP, fibrinogen, leptin, TNF-alpha, IL-6 were measured. Ultrasounds were used for FMD measurement, chemiluminescence for monocyte respiratory burst (RB), ELISA for C peptide and spectrophotometry for usual parameters. In the obese children versus the lean ones, the FMD was lower (p<0.001), the plasma values for TNF-alpha were similar (1.68 pg/mL vs 1.54 pg/mL), while plasma IL-6 was increased (4.01 pg/mL vs. 2.02 pg/mL, p<0.05). These cytokines were negatively correlated with FMD (r=-0.42, p<0.05) and positively with RB (r=50, p< 0.05). The FMD was negatively correlated (p<0.05) with the values for diastolic blood pressure (r =-0.47), waist circumference (r =-0.55), uric acid (r =0.47) and atherosclerotic index (r=In conclusion, in the obese children, inflammation, dyslipidaemia, blood pressure and oxidative stress act in a cluster reducing the elasticity of the vessel walls.
C1 [Popescu, Laura Anca; Virgolici, Bogdana; Stefan, Daciana Costina Andrada; Lixandru, Daniela; Virgolici, Horia; Oraseanu, Dumitru; Sinescu, Crina; Mohora, Maria] Carol Davila Univ Med & Pharm, 4 Traian Vuia Str, Bucharest 020956, Romania.
   [Timnea, Olivia] Ecol Univ Bucharest, Fac Phys Educ & Sports, 1G Vasile Milea Blvd, Bucharest 061345, Romania.
C3 Carol Davila University of Medicine & Pharmacy; Ecological University of
   Bucharest
RP Virgolici, B (corresponding author), Carol Davila Univ Med & Pharm, 4 Traian Vuia Str, Bucharest 020956, Romania.
EM hvirgolici@yahoo.com
RI Sinescu, Crina/AAA-8793-2021; Timnea, Olivia Carmen/S-2790-2019;
   Lixandru, Daniela/U-4330-2017; Virgolici, Bogdana/MTF-9331-2025
OI Timnea, Olivia Carmen/0000-0002-7308-5709; Sinescu, Crina
   Julieta/0000-0001-5933-8549
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NR 43
TC 6
Z9 6
U1 1
U2 9
PU REVISTA CHIMIE SRL
PI BUCURESTI
PA CALES PLEVNEI NR 139A, SECTOR 6, BUCURESTI, ROMANIA
SN 0034-7752
J9 REV CHIM-BUCHAREST
JI Rev. Chim.
PD APR
PY 2017
VL 68
IS 4
BP 758
EP 762
PG 5
WC Chemistry, Multidisciplinary; Engineering, Chemical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Engineering
GA EU0WJ
UT WOS:000400732400027
DA 2025-06-11
ER

PT J
AU Tao, C
   Sifuentes, A
   Holland, WL
AF Tao, Caroline
   Sifuentes, Angelica
   Holland, William L.
TI Regulation of glucose and lipid homeostasis by adiponectin: Effects on
   hepatocytes, pancreatic β cells and adipocytes
SO BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Article
DE ceramide; insulin resistance; obesity
ID FATTY LIVER-DISEASE; HIGH-MOLECULAR-WEIGHT; ENDOPLASMIC-RETICULUM
   STRESS; HEPATIC INSULIN-RESISTANCE; ACTIVATED-RECEPTOR-GAMMA; METABOLIC
   SYNDROME; ADIPOSE-TISSUE; NONALCOHOLIC STEATOHEPATITIS; GENE-EXPRESSION;
   KNOCKOUT MICE
AB Adiponectin has received considerable attention for its potential anti-diabetic actions. The adipokine exerts control of glucose and lipid homeostasis via critical effects within the liver, adipose, and pancreas. By stimulating adipogenesis, opposing inflammation, and influencing rates of lipid oxidation and lipolysis, adiponectin critically governs lipid spillover into non-adipose tissues. Ceramide, a cytotoxic and insulin desensitizing lipid metabolite formed when peripheral tissues are exposed to excessive lipid deposition, is potently opposed by adiponectin. Via adiponectin receptors, AdipoR1 and AdipoR2, adiponectin stimulates the deacylation of ceramide- yielding sphingosine for conversion to sphingosine 1-phosphate (SIP) by sphingosine kinase. The resulting conversion from ceramide to S1P promotes survival of functional beta cell mass, allowing for insulin production to meet insulin demands. Alleviation of ceramide burden on the liver allows for improvements in hepatic insulin action. Here, we summarize how adiponectin-induced changes in these tissues lead to improvements in glucose metabolism, highlighting the sphingolipid signaling mechanisms linking adiponectin to each action. One sentence summary: We review the anti-diabetic actions of adiponectin. Published by Elsevier Ltd.
C1 [Tao, Caroline; Sifuentes, Angelica; Holland, William L.] Univ Texas SW Med Ctr Dallas, Touchstone Diabet Ctr, Dept Internal Med, Dallas, TX 75390 USA.
C3 University of Texas System; University of Texas Southwestern Medical
   Center Dallas
RP Holland, WL (corresponding author), Univ Texas SW Med Ctr Dallas, Touchstone Diabet Ctr, Dept Internal Med, Dallas, TX 75390 USA.
EM william.holland@utsouthwestern.edu
FU National Institutes of Health [K99-DK094973]; American Heart Association
   [12BGI-A8910006]
FX The authors would like to acknowledge the National Institutes of Health
   (K99-DK094973) and American Heart Association (12BGI-A8910006) for
   funding to W.L.H.
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NR 126
TC 112
Z9 115
U1 1
U2 19
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1521-690X
EI 1532-1908
J9 BEST PRACT RES CL EN
JI Best Pract. Res. Clin. Endoc. Metab.
PD JAN
PY 2014
VL 28
IS 1
BP 43
EP 58
DI 10.1016/j.beem.2013.11.003
PG 16
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA AA0WE
UT WOS:000330817300006
PM 24417945
OA Green Accepted
DA 2025-06-11
ER

PT J
AU dos Santos, PR
   Danetti, S
   Rastegar, AJ
   de Souza, WV
   Frassini, R
   Scariot, FJ
   Moura, S
   Roesch-Ely, M
AF dos Santos, Paulo R.
   Danetti, Sidineia
   Rastegar, A. Joseph
   de Souza, Wellington V.
   Frassini, Rafaele
   Scariot, Fernando J.
   Moura, Sidnei
   Roesch-Ely, Mariana
TI Hydroxyhydroquinone and Quassinoids as Promising Compounds with
   Hypoglycemic Activity through Redox Balance
SO COMPOUNDS
LA English
DT Article
DE insulin resistance; diabetes mellitus type II; metabolic syndrome; ATP;
   hydroxyhydroquinone; quassinoids; flavonoids; glycemia; gluconeogenesis;
   mitochondria; cell energy production; redox system; FOXO1
ID MITOCHONDRIAL DYSFUNCTION; INSULIN-RESISTANCE; HEPG2 CELLS; FOXO1;
   CONSEQUENCES; HEPATOCYTES; MECHANISMS; STRESS; LIVER; AKT
AB In the present study, an insulin-resistant cell model (human hepatocellular carcinoma cell line: HepG2) was chosen to investigate the efficacy of two compound classes and their common molecular motif for glycemic control and insulin sensitization. The two compounds' classes were flavonoid extracts from Rourea cuspidata and quassinoid extracts from Picrasma crenata. The flavonoid-like hydroxyhydroquinone (HHQ) was synthesized. HepG2 cells were tested in a high-glucose environment (HepG2/IRM) by monitoring ROS activity, the concentration of adenosine triphosphate (ATP), and the measurement of mitochondrial membrane potential (MMP). The expression of forkhead box O1 (FOXO1) protein, which mediates gluconeogenesis and insulin resistance, was also investigated using indirect immunocytochemistry and Western blot techniques. A significant increase in glucose uptake and well-regulated ATP concentrations were observed in the treated cells. The downregulation of FOXO1 expression was seen in cells treated with HHQ and quassinoids in comparison to cells treated with flavonoids. This study provides a pharmacological basis for the application of HHQ, quassinoids from P. crenata, and flavonoids from R. cuspidata in the treatment of metabolic diseases such as type 2 diabetes mellitus.
C1 [dos Santos, Paulo R.; Danetti, Sidineia; Moura, Sidnei] Univ Caxias Do Sul, Lab Biotechnol Nat & Synthet Prod, BR-95070560 Caxias Do Sul, Brazil.
   [Rastegar, A. Joseph; de Souza, Wellington V.; Frassini, Rafaele] Univ Caxias Do Sul, Lab Appl Toxicol & Bioprod, BR-95070560 Caxias Do Sul, Brazil.
   [Scariot, Fernando J.; Roesch-Ely, Mariana] Univ Caxias Do Sul, Lab Appl Microbiol, BR-95070560 Caxias Do Sul, Brazil.
   [Roesch-Ely, Mariana] Univ Caxias Do Sul, Inst Biotechnol, BR-95070560 Caxias Do Sul, Brazil.
C3 Universidade de Caxias do Sul; Universidade de Caxias do Sul;
   Universidade de Caxias do Sul; Universidade de Caxias do Sul
RP Roesch-Ely, M (corresponding author), Univ Caxias Do Sul, Lab Appl Microbiol, BR-95070560 Caxias Do Sul, Brazil.; Roesch-Ely, M (corresponding author), Univ Caxias Do Sul, Inst Biotechnol, BR-95070560 Caxias Do Sul, Brazil.
EM sidmoura@ucs.br; mrely@ucs.br
RI dos Santos, Paulo/AAU-6617-2020; Roesch-Ely, Mariana/H-5981-2013
OI Vieira de Souza, Wellington/0000-0002-3596-1317; dos Santos, Paulo
   Roberto/0000-0002-5777-9073
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NR 49
TC 0
Z9 0
U1 2
U2 6
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2673-6918
J9 COMPOUNDS-BASEL
JI Compounds
PD MAR
PY 2024
VL 4
IS 1
BP 17
EP 36
DI 10.3390/compounds4010002
PG 20
WC Chemistry, Multidisciplinary
WE Emerging Sources Citation Index (ESCI)
SC Chemistry
GA PR8F3
UT WOS:001215894100001
OA gold
DA 2025-06-11
ER

PT J
AU Ma, SS
   Yang, B
   Shi, YC
   Du, Y
   Lv, YW
   Liu, JR
   Liu, EY
   Xu, HC
   Deng, L
   Chen, XY
AF Ma, Shengsuo
   Yang, Bing
   Shi, Yucong
   Du, Yang
   Lv, Yiwen
   Liu, Jiarong
   Liu, Enyan
   Xu, Huachong
   Deng, Li
   Chen, Xiao-yin
TI Adlay (Coix lacryma-jobi L.) Polyphenol Improves Hepatic Glucose
   and Lipid Homeostasis through Regulating Intestinal Flora via AMPK
   Pathway
SO MOLECULAR NUTRITION & FOOD RESEARCH
LA English
DT Article
DE AMPK; Coix lacryma-jobi L; intestinal flora; lipid homeostasis;
   non-alcoholic fatty liver disease; polyphenol
ID OXIDATIVE STRESS; LIVER-DISEASE; AUTOPHAGY; CHOLESTEROL; PROGRESSION;
   INHIBITION; THERAPY; EXTRACT; AXIS
AB Scope Non-alcoholic fatty liver disease (NAFLD) is a type of metabolic syndrome characterized of abnormal lipid deposition in the liver. Adlay polyphenol (AP), an effective component extracted from Coix lacryma-jobi L., has been reported that it can be used as a dietary supplement to prevent NAFLD. In this study, the mechanism and action of AP on lipid metabolism and regulation of intestinal flora are investigated. Methods and results AP significantly decreases the lipid accumulation in free fatty acid-treated HepG2 cells. Western blot results indicate that AP improves lipid metabolism via activating the p-AMPK/p-ACC pathway. In vivo experiments show AP treatment significantly decreases the body weight, liver weight, hepatic triglyceride, and total cholesterol contents, as well as the serum glucose levels in high fat diet-fed mice, which may affect lipid accumulation by activating AMPK pathway and changing intestinal bacterial communities and intestinal microbiome metabolism. Conclusion AP can be used as a food supplement for improving lipid metabolic dysfunction and reducing the incidence of metabolic diseases.
C1 [Ma, Shengsuo; Yang, Bing; Shi, Yucong; Du, Yang; Lv, Yiwen; Liu, Jiarong; Liu, Enyan; Xu, Huachong; Deng, Li; Chen, Xiao-yin] Jinan Univ, Sch Tradit Chinese Med, Guangzhou 510632, Guangdong, Peoples R China.
   [Yang, Bing] Yuebei Peoples Hosp, Dept Tradit Chinese Med, Shaoguan 512026, Guangdong, Peoples R China.
   [Deng, Li] Univ Chinese Med, Guangdong Prov Key Lab Clin Res Tradit Chinese Me, Affiliated Hosp Guangzhou 2,Guangdong Prov Key La, Syndrome Chinese Med,AMI Key Lab Chinese Med Guan, Guangzhou 510632, Guangdong, Peoples R China.
C3 Jinan University; Shantou University; Guangzhou University of Chinese
   Medicine
RP Xu, HC; Deng, L; Chen, XY (corresponding author), Jinan Univ, Sch Tradit Chinese Med, Guangzhou 510632, Guangdong, Peoples R China.; Deng, L (corresponding author), Univ Chinese Med, Guangdong Prov Key Lab Clin Res Tradit Chinese Me, Affiliated Hosp Guangzhou 2,Guangdong Prov Key La, Syndrome Chinese Med,AMI Key Lab Chinese Med Guan, Guangzhou 510632, Guangdong, Peoples R China.
EM xuhuachong@jnu.edu.cn; dengli@jnu.edu.cn; tchenxiaoyin@jnu.edu.cn
RI Xu, Huachong/JHT-4958-2023; Deng, Li/A-7233-2015; Ma,
   Shengsuo/LWJ-7803-2024; liu, JiaRong/KMA-7122-2024
OI Chen, Xiaoyin/0000-0001-5109-4287; Xu, Huachong/0000-0003-4046-7599;
   Deng, Li/0000-0002-1522-4184
FU Guangdong Basic and Applied Basic Research Foundation, China
   [2021A1515011215, 2020A1515010756]; Project of Administration of
   Traditional Chinese Medicine of Guangdong Province [20201074]; Project
   of Guangdong Hospital of Traditional Chinese Medicine [SZ2021KF13];
   China Postdoctoral Science Foundation [2020M683206]
FX This work was supported by the Guangdong Basic and Applied Basic
   Research Foundation, China (No. 2021A1515011215 and No.
   2020A1515010756). Project of Administration of Traditional Chinese
   Medicine of Guangdong Province (No. 20201074). Project of Guangdong
   Hospital of Traditional Chinese Medicine (No. SZ2021KF13). The China
   Postdoctoral Science Foundation (No. 2020M683206).
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NR 42
TC 9
Z9 9
U1 10
U2 45
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1613-4125
EI 1613-4133
J9 MOL NUTR FOOD RES
JI Mol. Nutr. Food Res.
PD DEC
PY 2022
VL 66
IS 23
DI 10.1002/mnfr.202200447
EA OCT 2022
PG 13
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA 8F6LL
UT WOS:000870536200001
PM 36214059
DA 2025-06-11
ER

PT J
AU Lee, SM
   Ha, E
   Ryoo, JH
AF Lee, Sang Min
   Ha, Eunhee
   Ryoo, Jae-Hong
TI Serum Gamma-Glutamyltransferase Levels Predict the Development of
   Cerebral Infarction in the Korean Population
SO NEUROPSYCHIATRIC DISEASE AND TREATMENT
LA English
DT Article
DE gamma-glutamyltransferase; cerebral infarction; stroke
ID CARDIOVASCULAR-DISEASE; ATRIAL-FIBRILLATION; METABOLIC SYNDROME; RISK;
   STROKE; ASSOCIATION; MORTALITY; STRESS
AB Purpose: This study examined the relationship between serum gamma-glutamyltransferase concentration and the risk of cerebral infarction in the Koreans. Materials and Methods: A total of 209,481 out of 223,551 participants in the National Health Information Database who received medical checkups in 2009 were included in the final analysis. The diagnosis code ICD I63 was used for identifying cerebral infarction cases and tracked the development of cerebral infarction by 2013. Cox proportional hazards model was used to calculate hazard ratios (HRs) for cerebral infarction and their confidence interval (CI). Results: During a follow-up period of 915,387.5 person-years, 2403 incident cases of cerebral infarction developed between 2009 and 2013. After adjusting for multiple covariates, the hazard ratios (95% confidence interval) for incident cerebral infarction, comparing the second, third, and fourth quartile of serum gamma-glutamyltransferase levels with the first quartile, were 1.11 (0.98-1.27), 1.39 (1.22-1.58), and 1.49 (1.29-1.71), respectively (P for trend <0.001). Conclusion: Elevated serum gamma-glutamyltransferase levels were independently associated with the future development of cerebral infarction in Koreans.
C1 [Lee, Sang Min] Kyung Hee Univ, Sch Med, Dept Psychiat, Med Ctr, Seoul, South Korea.
   [Ha, Eunhee] Ewha Womans Univ, Coll Med, Dept Occupat & Environm Med, Seoul, South Korea.
   [Ryoo, Jae-Hong] Kyung Hee Univ, Sch Med, Dept Occupat & Environm Med, 23 Kyungheedae Ro, Seoul 02447, South Korea.
C3 Kyung Hee University; Ewha Womans University; Kyung Hee University
RP Ryoo, JH (corresponding author), Kyung Hee Univ, Sch Med, Dept Occupat & Environm Med, 23 Kyungheedae Ro, Seoul 02447, South Korea.
EM armani131@naver.com
RI ; Lee, Sang Min/ABH-6121-2020
OI Ryoo, Jae-Hong/0000-0002-5232-1426; Lee, Sang Min/0000-0002-7834-8272
FU Kyung Hee University [KHU-20191056]; National Research Foundation of
   Korea [2020R1G1A1102257]
FX This work was supported by a grant from Kyung Hee University in 2019
   (KHU-20191056). This work was supported by the National Research
   Foundation of Korea in 2020 (grant number: 2020R1G1A1102257). The
   funding organization had no role in the design or conduct of this study.
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NR 25
TC 2
Z9 2
U1 0
U2 2
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
EI 1178-2021
J9 NEUROPSYCH DIS TREAT
JI Neuropsychiatr. Dis. Treat.
PY 2021
VL 17
BP 2749
EP 2756
DI 10.2147/NDT.S326450
PG 8
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Psychiatry
GA UG4MH
UT WOS:000689228200002
PM 34447250
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Oskouie, MN
   Moghaddam, NSA
   Butler, AE
   Zamani, P
   Sahebkar, A
AF Oskouie, Mohammad N.
   Moghaddam, Nazanin S. Aghili
   Butler, Alexandra E.
   Zamani, Parvin
   Sahebkar, Amirhossein
TI Therapeutic use of curcumin-encapsulated and curcumin-primed exosomes
SO JOURNAL OF CELLULAR PHYSIOLOGY
LA English
DT Review
DE curcumin (Cur); curcumin-encapsulated; curcumin-primed; exosome;
   nanoparticle
ID CHRONIC PULMONARY COMPLICATIONS; DRUG-DELIVERY SYSTEM; FATTY
   LIVER-DISEASE; QUALITY-OF-LIFE; EXTRACELLULAR VESICLES;
   CLINICAL-PRACTICE; SULFUR MUSTARD; DOUBLE-BLIND; PIPERINE COMBINATION;
   METABOLIC SYNDROME
AB Curcumin, the bioactive pigment of turmeric which has polyphenolic-hydrophobic components, has been used for the treatment of a variety of diseases. However, due to its insignificant intestinal-liver metabolism, low stability, quick systemic elimination and its hydrophobic property with low solubility, curcumin has limited bioavailability. Exosomes are nanovesicles (30-100 nm) released from diverse cell types into extracellular and, ultimately, into bio-fluids in a tightly regulated manner. Exosomes are capable of transferring lipids, proteins, RNAs and DNAs, both with and without direct cell-to-cell contact. Curcumin-encapsulated exosomes are highly bioavailable, soluble and safe, and can reach high concentrations in the blood; they, therefore, have therapeutic potential without toxic effects and immune stimulation. Thus, curcumin-encapsulated exosomes could be superior to other synthetic nanoparticles as a carrier of curcumin. The aim of the current review is to offer an overview of the in vitro, in vivo and clinical studies pertaining to the role of curcumin-primed and curcumin-encapsulated exosomes in the treatment of cancer, oxidative stress, brain disorders, cholesterol, and endothelial dysfunction.
C1 [Oskouie, Mohammad N.] Shahid Beheshti Univ Med Sci, Natl Nutr & Food Technol Res Inst, Fac Nutr & Food Technol, Dept Clin Nutr & Dietet, Tehran, Iran.
   [Moghaddam, Nazanin S. Aghili] Mashhad Univ Med Sci, Dept Nutr, Fac Med, Mashhad, Iran.
   [Butler, Alexandra E.] Qatar Biomed Res Inst, Diabet Res Ctr, Doha, Qatar.
   [Zamani, Parvin] Mashhad Univ Med Sci, Sch Med, Dept Med biotechnol, Nanotechnol Res Ctr,Student Res Comm, Mashhad, Iran.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Biotechnol Res Ctr, Mashhad, Iran.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Neurogen Inflammat Res Ctr, Mashhad, Iran.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Sch Pharm, Mashhad, Iran.
C3 Shahid Beheshti University Medical Sciences; Mashhad University of
   Medical Sciences; Qatar Foundation (QF); Hamad Bin Khalifa
   University-Qatar; Qatar Biomedical Research Institute (QBRI); Mashhad
   University of Medical Sciences; Mashhad University of Medical Sciences;
   Mashhad University of Medical Sciences; Mashhad University of Medical
   Sciences
RP Sahebkar, A (corresponding author), Mashhad Univ Med Sci, Biotechnol Res Ctr, Mashhad 9177948564, Iran.
EM sahebkara@mums.ac.ir
RI zamani, parvin/I-3759-2016; Sahebkar, Amirhossein/B-5124-2018
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NR 95
TC 102
Z9 112
U1 28
U2 389
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0021-9541
EI 1097-4652
J9 J CELL PHYSIOL
JI J. Cell. Physiol.
PD JUN
PY 2019
VL 234
IS 6
BP 8182
EP 8191
DI 10.1002/jcp.27615
PG 10
WC Cell Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Physiology
GA HM2QU
UT WOS:000459314500046
PM 30317632
DA 2025-06-11
ER

PT J
AU Clark, JL
   Zahradka, P
   Taylor, CG
AF Clark, Jaime L.
   Zahradka, Peter
   Taylor, Carla G.
TI Efficacy of flavonoids in the management of high blood pressure
SO NUTRITION REVIEWS
LA English
DT Review
DE blood pressure; endothelial function; flavonoids; hypertension
ID NITRIC-OXIDE; ENDOTHELIAL FUNCTION; OXIDATIVE STRESS; DISEASE RISK;
   ANTIINFLAMMATORY PROPERTIES; SCIENTIFIC STATEMENT; GLUCOSYL HESPERIDIN;
   INFLAMMATORY STATUS; DIETARY FLAVONOIDS; PUBLIC-EDUCATION
AB Plant compounds such as flavonoids have been reported to exert beneficial effects in cardiovascular disease, including hypertension. Information on the effects of isolated individual flavonoids for management of high blood pressure, however, is more limited. This review is focused on the flavonoids, as isolated outside of the food matrix, from the 5 main subgroups consumed in the Western diet (flavones, flavonols, flavanones, flavan-3-ols, and anthocyanins), along with their effects on hypertension, including the potential mechanisms for regulating blood pressure. Flavonoids from all 5 subgroups have been shown to attenuate a rise in or to reduce blood pressure during several pathological conditions (hypertension, metabolic syndrome, and diabetes mellitus). Flavones, flavonols, flavanones, and flavanols were able to modulate blood pressure by restoring endothelial function, either directly, by affecting nitric oxide levels, or indirectly, through other pathways. Quercetin had the most consistent blood pressure-lowering effect in animal and human studies, irrespective of dose, duration, or disease status. However, further research on the safety and efficacy of the flavonoids is required before any of them can be used by humans, presumably in supplement form, at the doses required for therapeutic benefit.
C1 [Clark, Jaime L.; Zahradka, Peter; Taylor, Carla G.] St Boniface Res Ctr, Canadian Ctr Agri Food Res Hlth & Med, R2034 351 Tache Ave, Winnipeg, MB R2H 2A6, Canada.
   [Clark, Jaime L.; Zahradka, Peter; Taylor, Carla G.] Univ Manitoba, Dept Human Nutr Sci, Winnipeg, MB R3T 2N2, Canada.
   [Zahradka, Peter; Taylor, Carla G.] Univ Manitoba, Dept Physiol & Pathophysiol, Winnipeg, MB R3T 2N2, Canada.
C3 University of Manitoba; Saint Boniface Hospital; Children's Hospital
   Research Institute of Manitoba; University of Manitoba; University of
   Manitoba
RP Taylor, CG (corresponding author), St Boniface Res Ctr, Canadian Ctr Agri Food Res Hlth & Med, R2034 351 Tache Ave, Winnipeg, MB R2H 2A6, Canada.
EM ctaylor@sbrc.ca
RI Zahradka, Peter/KDM-4700-2024
OI Clark, Jaime/0000-0001-8322-5149; Zahradka, Peter/0000-0002-7814-0658;
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NR 151
TC 88
Z9 93
U1 3
U2 62
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0029-6643
EI 1753-4887
J9 NUTR REV
JI Nutr. Rev.
PD DEC
PY 2015
VL 73
IS 12
BP 799
EP 822
DI 10.1093/nutrit/nuv048
PG 24
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA DB3NC
UT WOS:000368417400001
PM 26491142
OA Bronze
DA 2025-06-11
ER

PT J
AU Chen, SQ
   Sun, FZ
   Huang, XY
   Wang, XH
   Tang, N
   Zhu, BY
   Li, B
AF Chen, Shuqiang
   Sun, Fang-zhen
   Huang, Xiuying
   Wang, Xiaohong
   Tang, Na
   Zhu, Baoyi
   Li, Bo
TI Assisted reproduction causes placental maldevelopment and dysfunction
   linked to reduced fetal weight in mice
SO SCIENTIFIC REPORTS
LA English
DT Article
ID ALTERED GENE-EXPRESSION; IN-VITRO FERTILIZATION; IMPRINTED GENES;
   SINGLETON PREGNANCIES; NUTRIENT TRANSPORT; MATERNAL-BEHAVIOR; MOUSE
   MODEL; GROWTH; OVERGROWTH; OUTCOMES
AB Compelling evidence indicates that stress in utero, as manifested by low birth weight (LBW), increases the risk of metabolic syndrome in adulthood. Singletons conceived by assisted reproductive technology (ART) display a significant increase in LBW risk and ART offspring have a different metabolic profile starting at birth. Here, used mouse as a model, we found that ART resulted in reduced fetal weight and placental overgrowth at embryonic day 18.5 (E18.5). The ART placentae exhibited histomorphological alterations with defects in placental layer segregation and glycogen cells migration at E18.5. Further, ART treatments resulted in downregulation of a majority of placental nutrient transporters and reduction in placental efficiency. Moreover, the ART placentae were associated with increased methylation levels at imprinting control regions of H19, KvDMR1 and disrupted expression of a majority of imprinted genes important for placental development and function at E18.5. Our results from the mouse model show the first piece of evidence that ART treatment could affect fetal growth by disrupting placental development and function, suggests that perturbation of genomic imprinting resulted from embryo manipulation may contribute to these problems.
C1 [Chen, Shuqiang; Wang, Xiaohong; Zhu, Baoyi; Li, Bo] Fourth Mil Med Univ, Tangdu Hosp, Dept Obstet & Gynecol, Xian 710038, Peoples R China.
   [Chen, Shuqiang; Sun, Fang-zhen; Huang, Xiuying] Chinese Acad Sci, Inst Genet & Dev Biol, Mol & Dev Biol Lab, Beijing 100080, Peoples R China.
   [Tang, Na] Shaanxi Inst Food & Drug Control, Xian 710038, Peoples R China.
C3 Air Force Medical University; Chinese Academy of Sciences; Institute of
   Genetics & Developmental Biology, CAS
RP Chen, SQ (corresponding author), Fourth Mil Med Univ, Tangdu Hosp, Dept Obstet & Gynecol, Xian 710038, Peoples R China.
EM lbtn2000@126.com
RI Wang, Xiaohong/S-4334-2019
OI Li, Bo/0000-0001-7818-0070; Chen, Shuqiang/0000-0002-2505-4174
FU National Natural Science Foundation of China [81300531]; National Basic
   Research Program of China [2012 CB944900]; Scientific and Technical
   Innovatory Project of Tangdu hospital [2013CXTS015]
FX This work was supported by grants from the National Natural Science
   Foundation of China (81300531), National Basic Research Program of China
   (2012 CB944900) and Scientific and Technical Innovatory Project of
   Tangdu hospital (2013CXTS015). We thank Dr. Lei Pan from Institute of
   Genetics and Developmental Biology, Chinese Academy of Sciences for
   skillful technical assistance. We also appreciate the valuable comments
   from other members of our laboratory.
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NR 55
TC 68
Z9 74
U1 1
U2 32
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD JUN 18
PY 2015
VL 5
AR 10596
DI 10.1038/srep10596
PG 14
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA CK8XV
UT WOS:000356524400001
PM 26085229
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Sanches, SCL
   Ramalho, LNZ
   Augusto, MJ
   da Silva, DM
   Ramalho, FS
AF Sanches, Sheila Cristina L.
   Ramalho, Leandra Naira Z.
   Augusto, Marlei Josiele
   da Silva, Deisy Mara
   Ramalho, Fernando Silva
TI Nonalcoholic Steatohepatitis: A Search for Factual Animal Models
SO BIOMED RESEARCH INTERNATIONAL
LA English
DT Review
ID FATTY LIVER-DISEASE; INSULIN-RESISTANCE; OXIDATIVE STRESS;
   ADIPOSE-TISSUE; HEPATOCYTE APOPTOSIS; FRUCTOSE CONSUMPTION; METABOLIC
   SYNDROME; HEPATIC STEATOSIS; CAFETERIA DIET; RABBIT MODEL
AB Nonalcoholic fatty liver disease (NAFLD) is characterized by hepatic steatosis, which occurs in the absence of alcohol abuse. NAFLD can evolve into progressive liver injury and fibrosis in the form of nonalcoholic steatohepatitis (NASH). Several animal models have been developed to attempt to represent the morphological, biochemical, and clinical features of human NASH. The actual review presents a critical analysis of the most commonly used experimental models of NAFLD/NASH development. These models can be classified into genetic, nutritional, and a combination of genetic and nutritional factors. The main genetic models are ob/ob and db/db mutant mice and Zucker rats. The principal nutritional models employ methionine- and choline-deficient, high-fat, high-cholesterol and high-cholate, cafeteria, and high-fructose diets. Currently, associations between high-fructose and various compositions of high-fat diets have been widely studied. Previous studies have encountered significant difficulties in developing animal models capable of reproducing human NASH. Some models produce consistent morphological findings, but the induction method differs significantly compared with the pathophysiology of human NASH. Other models precisely represent the clinical and etiological contexts of this disease but fail to provide accurate histopathological representations mainly in the progression from steatosis to liver fibrosis.
C1 [Sanches, Sheila Cristina L.; Ramalho, Leandra Naira Z.; Augusto, Marlei Josiele; da Silva, Deisy Mara; Ramalho, Fernando Silva] Univ Sao Paulo, Sch Med Ribeirao Preto, Dept Pathol, BR-14049900 Ribeirao Preto, SP, Brazil.
C3 Universidade de Sao Paulo
RP Ramalho, FS (corresponding author), Univ Sao Paulo, Sch Med Ribeirao Preto, Dept Pathol, Ave Bandeirantes 3900, BR-14049900 Ribeirao Preto, SP, Brazil.
EM framalho@fmrp.usp.br
RI Ramalho, Leandra/A-3983-2010; Sanches, Sheila/K-9334-2015; Ramalho,
   Fernando/G-3817-2012
OI Ramalho, Leandra/0000-0002-3486-5294; Ramalho,
   Fernando/0000-0002-7529-466X
FU CNPq [160028/2012-4]; CAPES-PROAP; FAEPA
FX This research was supported by CNPq (fellowship to Sheila C. Sanches no.
   160028/2012-4), CAPES-PROAP, and FAEPA.
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NR 73
TC 135
Z9 153
U1 0
U2 31
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2314-6133
EI 2314-6141
J9 BIOMED RES INT
JI Biomed Res. Int.
PY 2015
VL 2015
AR 574832
DI 10.1155/2015/574832
PG 13
WC Biotechnology & Applied Microbiology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Research & Experimental Medicine
GA CI3TF
UT WOS:000354669600001
PM 26064924
OA Green Published, Green Submitted, hybrid
DA 2025-06-11
ER

PT J
AU Yu, XQ
   Yu, Z
   Chen, XL
   Liu, MJ
   Yang, F
   Cheung, KCP
AF Yu, Xianqiang
   Yu, Zeng
   Chen, Xiaoli
   Liu, Meijun
   Yang, Feng
   Cheung, Kenneth C. P.
TI Research Progress on the Relationship Between Artificial Sweeteners and
   Breast Cancer
SO BIOMEDICINES
LA English
DT Review
DE artificial sweeteners; breast cancer; estrogen; aspartame; oxidative
   stress; gut microbiome
ID HIGH-INTENSITY SWEETENERS; ESTROGEN PLUS PROGESTIN; GUT MICROBIOTA;
   INSULIN; HEALTH; BEVERAGES; ASPARTAME; ENERGY; RISK; CONSUMPTION
AB Artificial sweeteners, as low-calorie sugar substitutes, have attracted much attention in recent years, especially in terms of their potential health effects. Although they add almost no calories, studies have shown that artificial sweeteners may affect metabolism by stimulating insulin secretion and changing the intestinal microbiota, increasing the risk of metabolic syndrome and type 2 diabetes. Breast cancer, as the most common cancer in the world, is related to multiple factors such as genetics and hormone levels. The results of studies on artificial sweeteners and breast cancer risk are conflicting, with some showing a positive correlation between the two and others failing to confirm it. Differences in study design, participant characteristics, and the types of sweeteners have led to this ambiguity. Although some studies have focused on mechanisms such as hormone disorders, insulin response, and changes in the intestinal microbiota, further exploration is needed to establish a causal relationship. Our review aims to comprehensively analyze the potential association between artificial sweeteners and breast cancer and its mechanisms, as well as encourage future studies to reveal its long-term health effects.
C1 [Yu, Xianqiang] Qingdao Municipal Hosp, Qingdao 266005, Peoples R China.
   [Yu, Zeng; Chen, Xiaoli; Liu, Meijun; Cheung, Kenneth C. P.] Hong Kong Baptist Univ, Phenome Res Ctr, Sch Chinese Med, Hong Kong, Peoples R China.
   [Yang, Feng] Zhejiang Univ, Affiliated Hosp 1, Sch Med, Hangzhou 310003, Peoples R China.
C3 Qingdao Municipal Hospital; Hong Kong Baptist University; Zhejiang
   University
RP Cheung, KCP (corresponding author), Hong Kong Baptist Univ, Phenome Res Ctr, Sch Chinese Med, Hong Kong, Peoples R China.
EM yuxianqiang302@126.com; zengyu0718@163.com; xlchenucdavis@gmail.com;
   lmj20210322@163.com; yf3979988@163.com; kcpcheung@hkbu.edu.hk
RI Chen, Xiaoli/GPT-2554-2022; Cheung, Kenneth CP/HLW-8825-2023; Liu,
   Meijun/KQU-5985-2024; cheung, kenneth chat pan/Q-7665-2018
OI ZENG, YU/0009-0003-8351-6415; cheung, kenneth chat
   pan/0000-0002-7783-1780; Yu, Xianqiang/0000-0001-7879-9826
FU General Research Fund (GRF); France/Hong Kong Joint Research Scheme
   [HKBU201/22]; PROCORE [AY2020/21];  [12101023]
FX The funding was provided by the General Research Fund (GRF) under grant
   number 12101023; the France/Hong Kong Joint Research Scheme under grant
   number HKBU201/22, PROCORE; and the Research Committee's Startup Grant
   (Tier 1) for the academic year 2020/21 with grant number: AY2020/21.
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NR 86
TC 1
Z9 1
U1 7
U2 7
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2227-9059
J9 BIOMEDICINES
JI Biomedicines
PD DEC
PY 2024
VL 12
IS 12
AR 2871
DI 10.3390/biomedicines12122871
PG 14
WC Biochemistry & Molecular Biology; Medicine, Research & Experimental;
   Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Research & Experimental Medicine;
   Pharmacology & Pharmacy
GA Q7X2N
UT WOS:001386752100001
PM 39767777
OA gold
DA 2025-06-11
ER

PT J
AU Dai, HJ
   Chen, QR
   Huang, HY
   Wu, KL
   Yang, X
AF Dai, Hongju
   Chen, Qiurong
   Huang, Hongyu
   Wu, Kaili
   Yang, Xue
TI The Role of Nurses in Taking Care of Children With Type 1 Diabetes
SO ALTERNATIVE THERAPIES IN HEALTH AND MEDICINE
LA English
DT Review
ID METABOLIC SYNDROME; MANAGEMENT; ADOLESCENTS; MELLITUS; STRESS; TARGET
AB Type 1 diabetes (T1D) is an autoimmune disease leading to an insulin deficiency that causes hyperglycemia and associated symptoms. It is considered the most common type of diabetes, with the 4Ts (going to the toilet a lot, being really thirsty, feeling more tired than usual, losing weight or looking thinner than usual) being the most prevalent symptoms. Non-specific signs and symptoms are also possible, and delaying or missing the diagnosis can have a devastating effect on a child's health. Children with a definitive diagnosis of diabetes often require medical treatment for problems such as ketoacidosis, hypoglycemia and hyperglycemia. To reach glycated hemoglobin (HbA1c) values of 48 mmol/mol, lifetime rigorous monitoring and management of blood glucose levels via insulin replacement treatment is needed in T1D.
   Physical and psychosocial issues arise frequently with a diabetes diagnosis, resulting in poor management. Nurses play a significant role in detecting diabetes in a number of healthcare settings, resulting in quick diagnoses and prompt initiation of treatment. Not only do they provide critical assistance to help children and their families with the diagnosis, they also place particular emphasis on managing difficult days and common problems with ongoing management. Nurses can provide invaluable assistance managing this chronic condition by coping with day-to-day challenges.
C1 [Dai, Hongju; Chen, Qiurong; Huang, Hongyu; Wu, Kaili] Sichuan Univ, West China Univ Hosp 2, Dept Pediat Hematol & Oncol Nursing, Chengdu, Peoples R China.
   [Dai, Hongju; Chen, Qiurong; Huang, Hongyu; Wu, Kaili; Yang, Xue] Sichuan Univ, Key Lab Birth Defects & Related Dis Women & Child, Chengdu, Peoples R China.
   [Yang, Xue] Sichuan Univ, West China Univ Hosp 2, Dept Pediat, Chengdu, Peoples R China.
C3 Sichuan University; Sichuan University; Sichuan University
RP Yang, X (corresponding author), Sichuan Univ, Key Lab Birth Defects & Related Dis Women & Child, Chengdu, Peoples R China.; Yang, X (corresponding author), Sichuan Univ, West China Univ Hosp 2, Dept Pediat, Chengdu, Peoples R China.
EM yangxue08312017@126.com
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NR 58
TC 4
Z9 4
U1 1
U2 8
PU InnoVision Professional Media
PI Eagan
PA 3470 Washington Drive Suite 102, Eagan, MN 55122, UNITED STATES
SN 1078-6791
J9 ALTERN THER HEALTH M
JI Altern. Ther. Health Med.
PD JAN
PY 2022
VL 28
IS 1
BP 107
EP 113
PG 7
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA 4N2AK
UT WOS:000853820300010
PM 34559683
DA 2025-06-11
ER

PT J
AU Sinicropi, MS
   Baldino, N
   Ceramella, J
   Iacopetta, D
   Scali, E
   Basile, G
   Saturnino, C
   Catalano, A
AF Sinicropi, Maria Stefania
   Baldino, Noemi
   Ceramella, Jessica
   Iacopetta, Domenico
   Scali, Elisabetta
   Basile, Giovanna
   Saturnino, Carmela
   Catalano, Alessia
TI Opuntia ficus indica (L.) Mill. An Ancient Plant Source of
   Nutraceuticals
SO CURRENT TOPICS IN MEDICINAL CHEMISTRY
LA English
DT Article
DE Opuntia ficus-indica; Nutraceuticals; Cactus pear; Prickly pear; Health;
   Bioactive compounds
ID FAECALIS THYMIDYLATE SYNTHASE; WOUND-HEALING ACTIVITY;
   CHEMICAL-CHARACTERIZATION; ANTIOXIDANT CAPACITY; TRADITIONAL FOODS;
   OXIDATIVE STRESS; CLADODES; EXTRACT; FRUIT; JUICE
AB Opuntia ficus-indica (L.) Mill. (OFI) is a plant with numerous beneficial properties known in traditional medicine. It has been a domesticated plant in Latin America, Africa, Mediterranean countries, the Middle East, India and Australia. Nowadays, the research concentrates on natural compounds to lower costs and the possible side effects of synthetic compounds. The use of nutraceuticals, bioactive compounds of vegetable origin with important nutritional values, is encouraged. OFI has shown numerous activities due to its high content of antioxidants, including flavonoids and ascorbate, pigments, carotenoids and betalains, phenolic acids and other phytochemical components, such as biopeptides and soluble fibers. The most important effects of OFI are represented by the activity against acne, arthrosis, dermatosis, diabetes, diarrhea, fever, high blood pressure, prostatitis, rheumatism, stomachache, tumor, wart, allergy, wound, colitis and some viral diseases. Moreover, a promising role has been suggested in inflammatory bowel disease, colitis and metabolic syndrome. The most recent studies addressed the role of OFI in preventing and treating COVID-19 disease. In light of the above, this review summarizes the biological activities and health benefits that this plant may exert.
C1 [Sinicropi, Maria Stefania; Ceramella, Jessica; Iacopetta, Domenico; Basile, Giovanna] Univ Calabria, Dept Pharm Hlth & Nutrit Sci, I-87036 Arcavacata Di Rende, CS, Italy.
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   [Scali, Elisabetta] Magna Graecia Univ Catanzaro, Dept Hlth Sci, I-88100 Catanzaro, Italy.
   [Saturnino, Carmela] Univ Basilicata, Dept Sci, I-85100 Potenza, Italy.
   [Catalano, Alessia] Univ Bari Aldo Moro, Dept Pharm Drug Sci, I-70126 Bari, Italy.
C3 University of Calabria; University of Calabria; Magna Graecia University
   of Catanzaro; Italfarmaco; University of Basilicata; Universita degli
   Studi di Bari Aldo Moro
RP Iacopetta, D (corresponding author), Univ Calabria, Dept Pharm Hlth & Nutrit Sci, I-87036 Arcavacata Di Rende, CS, Italy.
EM domenico.iacopetta@unical.it
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NR 130
TC 10
Z9 10
U1 0
U2 14
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1568-0266
EI 1873-4294
J9 CURR TOP MED CHEM
JI Curr. Top. Med. Chem.
PY 2022
VL 22
IS 21
BP 1736
EP 1749
DI 10.2174/1568026622666220803151814
PG 14
WC Chemistry, Medicinal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 6C0IS
UT WOS:000881708400003
PM 35927821
DA 2025-06-11
ER

PT J
AU Armeli, F
   Bonucci, A
   Maggi, E
   Pinto, A
   Businaro, R
AF Armeli, Federica
   Bonucci, Alessio
   Maggi, Elisa
   Pinto, Alessandro
   Businaro, Rita
TI Mediterranean Diet and Neurodegenerative Diseases: The Neglected Role of
   Nutrition in the Modulation of the Endocannabinoid System
SO BIOMOLECULES
LA English
DT Review
DE endocannabinoids; mediterranean diet; neuroinflammation
ID FATTY-ACID AMIDE; ACTIVATED-RECEPTOR-GAMMA; CANNABINOID CB2 RECEPTOR;
   BETA-CARYOPHYLLENE PROTECTS; ALZHEIMER-LIKE PHENOTYPE; NITRIC-OXIDE
   SYNTHASE; PPAR-GAMMA; PARKINSONS-DISEASE; N-ACYLETHANOLAMINES; METABOLIC
   SYNDROME
AB Neurodegenerative disorders are a widespread cause of morbidity and mortality worldwide, characterized by neuroinflammation, oxidative stress and neuronal depletion. The broad-spectrum neuroprotective activity of the Mediterranean diet is widely documented, but it is not yet known whether its nutritional and caloric balance can induce a modulation of the endocannabinoid system. In recent decades, many studies have shown how endocannabinoid tone enhancement may be a promising new therapeutic strategy to counteract the main hallmarks of neurodegeneration. From a phylogenetic point of view, the human co-evolution between the endocannabinoid system and dietary habits could play a key role in the pro-homeostatic activity of the Mediterranean lifestyle: this adaptive balance among our ancestors has been compromised by the modern Western diet, resulting in a "clinical endocannabinoid deficiency syndrome". This review aims to evaluate the evidence accumulated in the literature on the neuroprotective, immunomodulatory and antioxidant properties of the Mediterranean diet related to the modulation of the endocannabinoid system, suggesting new prospects for research and clinical interventions against neurodegenerative diseases in light of a nutraceutical paradigm.
C1 [Armeli, Federica; Bonucci, Alessio; Maggi, Elisa; Businaro, Rita] Sapienza Univ Rome, Dept Medicosurg Sci & Biotechnol, Corso Repubbl 79, I-04100 Latina, Italy.
   [Pinto, Alessandro] Sapienza Univ Rome, Dept Expt Med, I-00161 Rome, Italy.
C3 Sapienza University Rome; Sapienza University Rome
RP Businaro, R (corresponding author), Sapienza Univ Rome, Dept Medicosurg Sci & Biotechnol, Corso Repubbl 79, I-04100 Latina, Italy.
EM Federica.armeli@uniroma1.it; bonucci.alessio@libero.it;
   elisa.maggi@uniroma1.it; alessandro.pinto@uniroma1.it;
   rita.businaro@uniroma1.it
RI Businaro, Rita/AAG-1866-2021; Armeli, Federica/AAX-5882-2020
OI Pinto, Alessandro/0000-0002-4864-2294; Businaro,
   Rita/0000-0002-7890-8524; reverberi, massimo/0000-0003-3671-6783;
   Armeli, Federica/0000-0002-4981-3374
FU Sapienza Ateneo [RM120172B745088B]
FX Sapienza Ateneo RM120172B745088B to R.B.
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NR 335
TC 20
Z9 20
U1 4
U2 14
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2218-273X
J9 BIOMOLECULES
JI Biomolecules
PD JUN
PY 2021
VL 11
IS 6
AR 790
DI 10.3390/biom11060790
PG 35
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA SX6BI
UT WOS:000665287600001
PM 34073983
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Ahrabi, B
   Bahrami, M
   Moghadasali, R
   Zamanian-Azodi, M
   Khoramgah, MS
   Mirakabad, FST
   Darabi, S
   Abbaszadeh, HA
AF Ahrabi, Behnaz
   Bahrami, Maryam
   Moghadasali, Reza
   Zamanian-Azodi, Mona
   Khoramgah, Maryam Sadat
   Mirakabad, Fatemeh Sadat Tabatabaei
   Darabi, Shahram
   Abbaszadeh, Hojjat Allah
TI The Effect of Low-Power Laser Therapy on the TGF/β Signaling Pathway in
   Chronic Kidney Disease: A Review
SO JOURNAL OF LASERS IN MEDICAL SCIENCES
LA English
DT Review
DE Low-power laser therapy; Chronic kidney disease; TGF beta 1 signaling
ID MOLECULAR-MECHANISMS; OXIDATIVE STRESS; STEM-CELLS; TGF-BETA; FIBROSIS;
   PHOTOBIOMODULATION; COMMON
AB Objective: The purpose of this study is to investigate the effects of low-power lasers on kidney disease by investigating several studies.
   Methods: A number of articles from 1998 to 2019 were chosen from the sources of PubMed, Scopus, and only the articles studying the effect of low-power lasers on kidney disease were investigated.
   Results: After reviewing the literature, 21 articles examining only the effects of low-power lasers on kidney disease were found. The results of these studies showed that the parameter of the lowpower laser would result in different outcomes. So, a low-power laser with various parameters can be effective in the treatment of kidney diseases such as acute kidney disease, diabetes, glomerulonephritis, nephrectomy, metabolic syndrome, and kidney fibrosis. Most studies have shown that low-power lasers can affect TGF beta 1 signaling which is the most important signaling in the treatment of renal fibrosis.
   Conclusion: Lasers can be effective in reducing or enhancing inflammatory responses, reducing fibrosis factors, and decreasing reactive oxygen species (ROS) levels in kidney disease and glomerular cell proliferation.
C1 [Ahrabi, Behnaz; Khoramgah, Maryam Sadat; Mirakabad, Fatemeh Sadat Tabatabaei; Abbaszadeh, Hojjat Allah] Shahid Beheshti Univ Med Sci, Laser Applicat Med Sci Res Ctr, POB 19395-4719, Tehran, Iran.
   [Bahrami, Maryam] Shahid Beheshti Univ Med Sci, Sch Med, Dept Biol & Anat Sci, POB 19395-4719, Tehran, Iran.
   [Moghadasali, Reza] ACECR, Royan Inst Stem Cell Biol & Technol, Cell Sci Res Ctr, Dept Stem Cells & Dev Biol, Tehran, Iran.
   [Zamanian-Azodi, Mona] Shahid Beheshti Univ Med Sci, Prote Res Ctr, Tehran, Iran.
   [Darabi, Shahram] Qazvin Univ Med Sci, Cellular & Mol Res Ctr, Qazvin, Iran.
C3 Shahid Beheshti University Medical Sciences; Shahid Beheshti University
   Medical Sciences; Academic Center for Education, Culture & Research
   (ACECR); Shahid Beheshti University Medical Sciences; Qazvin University
   of Medical Sciences (QUMS)
RP Abbaszadeh, HA (corresponding author), Shahid Beheshti Univ Med Sci, Laser Applicat Med Sci Res Ctr, POB 19395-4719, Tehran, Iran.; Abbaszadeh, HA (corresponding author), Shahid Beheshti Univ Med Sci, Sch Med, Dept Biol & Anat Sci, POB 19395-4719, Tehran, Iran.
EM Dr.abbaszadeh79@gmail.com
RI Abbaszadeh, Hojjat/R-6726-2019
OI Abbaszadeh, Hojjat Allah/0000-0002-7157-1834
FU Laser application in Medical Sciences Research Center of Shahid Beheshti
   University of Medical Sciences, Tehran, Iran
FX This work was supported by the Laser application in Medical Sciences
   Research Center of Shahid Beheshti University of Medical Sciences,
   Tehran, Iran.
CR Abbaszadeh HA, 2014, TISSUE CELL, V46, P462, DOI 10.1016/j.tice.2014.08.003
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NR 26
TC 6
Z9 6
U1 0
U2 3
PU SHAHID BEHESHTI UNIV MEDICAL SCIENCES, FAC MEDICINE
PI TEHRAN
PA SCH MEDICINE, KOODAK-YAR ST, PO BOX 19395, TEHRAN, 4618, IRAN
SN 2008-9783
EI 2228-6721
J9 J LASERS MED SCI
JI J. Lasers Med. Sci.
PD SPR
PY 2020
VL 11
IS 2
BP 220
EP 225
DI 10.34172/jlms.2020.36
PG 6
WC Radiology, Nuclear Medicine & Medical Imaging
WE Emerging Sources Citation Index (ESCI)
SC Radiology, Nuclear Medicine & Medical Imaging
GA KW0LR
UT WOS:000520865800017
PM 32273966
OA Green Published, gold, Green Accepted
DA 2025-06-11
ER

PT J
AU Gouvêa, ES
   Santos, AF
   Ota, VK
   Mrad, V
   Gadelha, A
   Bressan, RA
   Cordeiro, Q
   Belangero, SI
AF Gouvea, Eduardo S.
   Santos Filho, Airton F.
   Ota, Vanessa K.
   Mrad, Vinicius
   Gadelha, Ary
   Bressan, Rodrigo A.
   Cordeiro, Quirino
   Belangero, Sintia I.
TI The role of the CNR1 gene in schizophrenia: a systematic review
   including unpublished data
SO REVISTA BRASILEIRA DE PSIQUIATRIA
LA English
DT Review
DE Cannabinoid receptors; cannabinoid receptors type-1; gene; association
   studies
ID CANNABINOID RECEPTOR GENE; INDUCED WEIGHT-GAIN; HEBEPHRENIC
   SCHIZOPHRENIA; FUNCTIONAL POLYMORPHISM; PSYCHOTIC SYMPTOMS; METABOLIC
   SYNDROME; SUBSTANCE-ABUSE; ADULT PSYCHOSIS; DRUG-ABUSE; 1 CB1
AB Objective: Schizophrenia is a multifactorial disorder. It is known that a combination of extensive multiple common alleles may be involved in its etiology, each contributing with a small to moderate effect, and, possibly, some rare alleles with a much larger effect size. We aimed to perform a systematic review of association studies between schizophrenia (and its subphenotypes) and polymorphisms in the CNR1 gene, which encodes cannabinoid receptors classically implicated in schizophrenia pathophysiology, as well as to present unpublished results of an association study in a Brazilian population.
   Methods: Two reviewers independently searched for eligible studies and extracted outcome data using a structured form. Papers were retrieved from PubMed and ISI Web of Knowledge using the search term schizophrenia in combination with CNR1 or CB1 or cannabinoid receptor. Twenty-four articles met our inclusion criteria. We additionally present data from a study of our own comparing 182 patients with schizophrenia and 244 healthy controls.
   Results: No consistent evidence is demonstrated.
   Conclusion: Some seemingly positive association studies stress the need for further investigations of the possible role of endocannabinoid genetics in schizophrenia.
C1 [Gouvea, Eduardo S.; Santos Filho, Airton F.; Ota, Vanessa K.; Gadelha, Ary; Bressan, Rodrigo A.; Cordeiro, Quirino; Belangero, Sintia I.] Univ Fed Sao Paulo UNIFESP, Dept Psiquiatria, Sao Paulo, SP, Brazil.
   [Gouvea, Eduardo S.; Santos Filho, Airton F.; Ota, Vanessa K.; Gadelha, Ary; Bressan, Rodrigo A.; Belangero, Sintia I.] Univ Fed Sao Paulo, Lab Interdisciplinar Neurociencias Clin LiNC, Sao Paulo, SP, Brazil.
   [Gouvea, Eduardo S.; Cordeiro, Quirino] Irmandade Santa Casa Misericordia Sao Paulo, Dept Psiquiatria, Sao Paulo, SP, Brazil.
   [Ota, Vanessa K.; Mrad, Vinicius; Belangero, Sintia I.] Univ Fed Sao Paulo, Dept Morfol & Genet, Sao Paulo, SP, Brazil.
C3 Universidade Federal de Sao Paulo (UNIFESP); Universidade Federal de Sao
   Paulo (UNIFESP); Universidade Federal de Sao Paulo (UNIFESP)
RP Belangero, SI (corresponding author), Univ Fed Sao Paulo, Dept Morfol & Genet, Rua Botucatu 740,Edificio Leitao Cunha,1 Andar, BR-04023900 Sao Paulo, SP, Brazil.
EM sinbelangero@gmail.com
RI Bressan, Rodrigo/E-9178-2010; Cordeiro, Quirino/E-1816-2013; Belangero,
   Sintia/A-6818-2009; Ota, Vanessa/J-6442-2012
OI Belangero, Sintia/0000-0002-2419-4351; Ota, Vanessa/0000-0003-0129-6360;
   Gadelha de Alencar Araripe Neto, Ary/0000-0002-0993-8017; Cordeiro,
   Quirino/0009-0001-0055-7875
FU Fundacao de Amparo e Pesquisa do Estado de Sao Paulo (FAPESP)
   [2010/08968-6, 2011/50740-5, 2011/00030-1]; Conselho Nacional de
   Desenvolvimento Cientifico e Tecnologico (CNPq); FAPESP; CNPq;
   Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES);
   Fundacao Safra; Fundacao ABADS; Fundacao de Amparo a Pesquisa do Estado
   de Sao Paulo (FAPESP) [11/00030-1, 10/08968-6, 11/50740-5] Funding
   Source: FAPESP
FX This study was funded by Fundacao de Amparo e Pesquisa do Estado de Sao
   Paulo (FAPESP; grants 2010/08968-6, 2011/50740-5, and 2011/00030-1). AG
   has received research support from Conselho Nacional de Desenvolvimento
   Cientifico e Tecnologico (CNPq). RAB has received research funding from
   FAPESP, CNPq, Coordenacao de Aperfeicoamento de Pessoal de Nivel
   Superior (CAPES), Fundacao Safra, and Fundacao ABADS.
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NR 55
TC 17
Z9 17
U1 0
U2 7
PU ASSOC BRASILEIRA PSIQUIATRIA
PI SAO PAULO
PA SUBSCRIPTION DEPARTMENT, RUA PEDRO DE TOLEDO, 967 - CASA 01, SAO PAULO,
   SP 04039-032  A, BRAZIL
SN 1516-4446
EI 1809-452X
J9 REV BRAS PSIQUIATR
JI Rev. Bras. Psiquiatr.
PD APR-JUN
PY 2017
VL 39
IS 2
BP 160
EP 171
DI 10.1590/1516-4446-2016-1969
PG 12
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA EX5II
UT WOS:000403273400013
PM 28099629
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Li, KK
   Peng, JM
   Zhu, W
   Cheng, BH
   Li, CM
AF Li, Kai Kai
   Peng, Jin Ming
   Zhu, Wei
   Cheng, Bao Hui
   Li, Chun Mei
TI Gallocatechin gallate (GCG) inhibits 3T3-L1 differentiation and
   lipopolysaccharide induced inflammation through MAPK and NF-κB signaling
SO JOURNAL OF FUNCTIONAL FOODS
LA English
DT Article
DE Gallocatechin gallate (GCG); Epigallocatechin gallate (EGCG);
   Anti-adipocyte; ROS; MAPK; NF-kappa B
ID GREEN TEA CATECHINS; ACTIVATED PROTEIN-KINASE; NECROSIS-FACTOR-ALPHA;
   ADIPOCYTE DIFFERENTIATION; INSULIN-RESISTANCE; LIPID-ACCUMULATION;
   METABOLIC SYNDROME; OXIDATIVE STRESS; ADIPOSE-TISSUE; PPAR-GAMMA
AB Gallocatechin gallate (GCG), as the epimer of Epigallocatechin gallate (EGCG), the content is low in traditional tea made from Camellia sinensis and C. assamica. However, previous studies found that the content of GCG was almost the same as EGCG in canned and bottled tea drinks. Accumulating evidences indicated that GCG possessed multiple biological activities, but the anti-obesity study of GCG is poorly reported. In this study, the anti-adipogenic activities of GCG were investigated. The results showed that as EGCG, GCG significantly reduced the intracellular lipid droplets and expressions of major adipogenic transcription factors, such as PPAR gamma, SREBP-lc and C/EBP alpha. Further study revealed that the expressions of FAS, ACC, FAT and SCD-1 were decreased in 3T3-L1 cells treated with GCG. GCG treatment also dose dependently decreased the intracellular ROS level, attenuated MAPK pathway activation in 3T3-L1 differentiations. Additionally, GCG decreased the activation of NF-kappa B, and down-regulated the production of IL-6 and MCP-1 induced by LPS. (C) 2017 Elsevier Ltd. All rights reserved.
C1 [Li, Kai Kai; Peng, Jin Ming; Zhu, Wei; Li, Chun Mei] Huazhong Agr Univ, Coll Food Sci & Technol, Wuhan 430070, Peoples R China.
   [Li, Kai Kai; Li, Chun Mei] Huazhong Agr Univ, Key Lab Environm Correlat Food Sci, Minist Educ, Wuhan 430070, Peoples R China.
   [Cheng, Bao Hui] Longgang ENT Hosp, Shenzhen Key Lab ENT, Shenzhen 518172, Peoples R China.
   [Cheng, Bao Hui] Inst ENT, Shenzhen 518172, Peoples R China.
C3 Huazhong Agricultural University; Huazhong Agricultural University;
   Ministry of Education - China; Longgang ENT Hospital, Shenzhen
RP Li, CM (corresponding author), Huazhong Agr Univ, Coll Food Sci & Technol, Wuhan 430070, Peoples R China.; Cheng, BH (corresponding author), Longgang ENT Hosp, Shenzhen Key Lab ENT, Shenzhen 518172, Peoples R China.; Cheng, BH (corresponding author), Inst ENT, Shenzhen 518172, Peoples R China.
EM chengbaohui@sina.com; lichmyl@mail.hzau.edu
RI Zhu, Wei/AFK-0930-2022; Li, Kaikai/JZE-4530-2024
OI Peng, Jinming/0000-0002-9630-8696; Zhu, Wei/0000-0002-7957-7843
FU Fundamental Research Funds for the Central Universities
   [52902-0900201562]; National Natural Science Foundation of China
   [31571839, 81403160]; Traditional Chinese Medicine Bureau of Guangdong
   Province [20161214]; Shenzhen Innovation of Science and Technology
   Commission [ZDSYS201506050935272, JCYJ20160429091935720,
   JCYJ20150403091931191, 20160608095820532, 201401099]
FX This work was supported by the Fundamental Research Funds for the
   Central Universities (Grant No. 52902-0900201562), the National Natural
   Science Foundation of China (No. 31571839 and 81403160), Traditional
   Chinese Medicine Bureau of Guangdong Province (20161214), and Shenzhen
   Innovation of Science and Technology Commission (No.
   ZDSYS201506050935272, JCYJ20160429091935720, JCYJ20150403091931191,
   20160608095820532, 201401099).
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NR 49
TC 21
Z9 24
U1 4
U2 52
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1756-4646
J9 J FUNCT FOODS
JI J. Funct. Food.
PD MAR
PY 2017
VL 30
BP 159
EP 167
DI 10.1016/j.jff.2017.01.016
PG 9
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA EL9FF
UT WOS:000394924700019
DA 2025-06-11
ER

PT J
AU Kim, MK
   Chon, SJ
   Jung, YS
   Kim, BO
   Noe, EB
   Yun, BH
   Cho, S
   Choi, YS
   Lee, BS
   Seo, SK
AF Kim, Min Kyoung
   Chon, Seung Joo
   Jung, Yeon Soo
   Kim, Bo Ok
   Noe, Eun Bee
   Yun, Bo Hyon
   Cho, SiHyun
   Choi, Young Sik
   Lee, Byung Seok
   Seo, Seok Kyo
TI The Relationship between Serum Ferritin Levels and Insulin Resistance in
   Pre- and Postmenopausal Korean Women: KNHANES 2007-2010
SO PLOS ONE
LA English
DT Article
ID METABOLIC SYNDROME; IRON-METABOLISM; OXIDATIVE STRESS; ASSOCIATION;
   HEALTH; INFLAMMATION; TRANSFERRIN; TRANSPORT; MARKERS; OBESITY
AB Background
   Serum ferritin levels increase in postmenopausal women, and they are reported to be linked to major health problems. Here, we investigated the association between serum ferritin levels and insulin resistance (IR) in postmenopausal women.
   Methods
   A total of 6632 healthy Korean women (4357 premenopausal and 2275 postmenopausal) who participated in the Korean National Health and Nutrition Examination Survey (KNHANES) in 2007-2010 were enrolled in the study. Serum ferritin values were divided into six groups for the premenopausal and postmenopausal groups. IR and obesity indices were evaluated according to the six serum ferritin groups. Statistical analysis was carried out using SAS software, version 9.2 (SAS Institute Inc., Cary, NC, USA).
   Results
   The association between the IR indices and ferritin groups had a higher level of statistical significance in the postmenopausal group than in the premenopausal group. In addition, for the postmenopausal group, the estimates increased significantly in the sixth ferritin group compared to those in the first ferritin group. However, the association between the obesity indices and ferritin levels was not significantly different between the premenopausal and postmenopausal groups.
   Conclusion
   Elevated serum ferritin levels were associated with an increased risk of insulin resistance in postmenopausal women.
C1 [Kim, Min Kyoung; Yun, Bo Hyon; Choi, Young Sik; Lee, Byung Seok; Seo, Seok Kyo] Yonsei Univ, Coll Med, Dept Obstet & Gynecol, Severance Hosp, Seoul 120749, South Korea.
   [Chon, Seung Joo] Gachon Univ, Coll Med, Gil Hosp, Dept Obstet & Gynecol, Inchon, South Korea.
   [Jung, Yeon Soo] Yonsei Univ, Wonju Coll Med, Wonju Severance Christian Hosp, Dept Obstet & Gynecol, Wonju, South Korea.
   [Kim, Bo Ok] Yonsei Univ, Coll Med, Biostat Collaborat Unit, Seoul 120749, South Korea.
   [Noe, Eun Bee] Seoul Rachel Fertil Ctr, Seoul, South Korea.
   [Cho, SiHyun] Yonsei Univ, Coll Med, Gangnam Severance Hosp, Dept Obstet & Gynecol, Seoul 120749, South Korea.
   [Kim, Min Kyoung; Yun, Bo Hyon; Cho, SiHyun; Choi, Young Sik; Lee, Byung Seok; Seo, Seok Kyo] Yonsei Univ, Coll Med, Inst Womens Life Med Sci, Seoul 120749, South Korea.
C3 Yonsei University; Yonsei University Health System; Gachon University;
   Yonsei University; Yonsei University; Yonsei University Health System;
   Yonsei University; Yonsei University Health System; Yonsei University;
   Yonsei University Health System
RP Seo, SK (corresponding author), Yonsei Univ, Coll Med, Dept Obstet & Gynecol, Severance Hosp, Seoul 120749, South Korea.; Seo, SK (corresponding author), Yonsei Univ, Coll Med, Inst Womens Life Med Sci, Seoul 120749, South Korea.
EM tudeolseo@yuhs.ac
RI Choi, Young/D-6594-2013; Cho, SiHyun/U-6048-2017; Noe,
   Egon/LUZ-7461-2024; lee, sang/Q-4650-2019
OI Seo, Seok Kyo/0000-0003-3404-0484; LEE, Byung Seok/0000-0001-6001-2079;
   Yun, Bo Hyon/0000-0001-5703-797X; Kim, Min Kyoung/0000-0002-1753-2674;
   Cho, SiHyun/0000-0003-2718-6645; Choi, Young Sik/0000-0002-1157-4822
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NR 34
TC 4
Z9 4
U1 0
U2 1
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JUN 23
PY 2016
VL 11
IS 6
AR e0157934
DI 10.1371/journal.pone.0157934
PG 13
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA DP3JL
UT WOS:000378389200067
PM 27337113
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Herr, RM
   Bosch, JA
   van Vianen, AEM
   Jarczok, MN
   Thayer, JF
   Li, J
   Schmidt, B
   Fischer, JE
   Loerbroks, A
AF Herr, Raphael M.
   Bosch, Jos A.
   van Vianen, Annelies E. M.
   Jarczok, Marc N.
   Thayer, Julian F.
   Li, Jian
   Schmidt, Burkhard
   Fischer, Joachim E.
   Loerbroks, Adrian
TI Organizational Justice Is Related to Heart Rate Variability in
   White-Collar Workers, but Not in Blue-Collar Workers-Findings from a
   Cross-Sectional Study
SO ANNALS OF BEHAVIORAL MEDICINE
LA English
DT Article
DE Organizational justice; Interactional justice; Procedural justice; Heart
   rate variability; Occupational group; White-collar; Blue-collar
ID EFFORT-REWARD IMBALANCE; JOB DECISION LATITUDE; PSYCHOLOGICAL CONTRACTS;
   SOCIAL-EXCHANGE; FAIRNESS PERCEPTIONS; METABOLIC SYNDROME; SLEEPING
   PROBLEMS; HEALTH; STRESS; DISEASE
AB Perceived injustice at work predicts coronary heart disease. Vagal dysregulation represents a potential psychobiological pathway.
   We examined associations between organizational justice and heart rate variability (HRV) indicators. Grounded in social exchange and psychological contract theory, we tested predictions that these associations are more pronounced among white-collar than among blue-collar workers.
   Cross-sectional data from 222 blue-collar and 179 white-collar men were used. Interactional and procedural justice were measured by questionnaire. Ambulatory HRV was assessed across 24 h. Standardized regression coefficients (beta) were calculated.
   Among white-collar workers, interactional justice showed positive relationships with 24-h HRV, which were strongest during sleeping time (adjusted beta s a parts per thousand yen0.26; p values a parts per thousand currency sign0.01). No associations were found for blue-collar workers. A comparable but attenuated pattern was observed for procedural justice.
   Both dimensions of organizational injustice were associated with lowered HRV among white-collar workers. The impact of justice and possibly its association with health seems to differ by occupational groups.
C1 [Herr, Raphael M.; Bosch, Jos A.; Jarczok, Marc N.; Schmidt, Burkhard; Fischer, Joachim E.; Loerbroks, Adrian] Heidelberg Univ, Med Fac Mannheim, Mannheim Inst Publ Hlth Social & Prevent Med, Mannheim, Germany.
   [Herr, Raphael M.; Bosch, Jos A.] Univ Amsterdam, Dept Clin Psychol, NL-1018 XA Amsterdam, Netherlands.
   [van Vianen, Annelies E. M.] Univ Amsterdam, Dept Work & Org Psychol, Amsterdam, Netherlands.
   [Thayer, Julian F.] Ohio State Univ, Dept Psychol, Columbus, OH 43210 USA.
   [Li, Jian; Loerbroks, Adrian] Univ Dusseldorf, Fac Med, Ctr Hlth & Soc, Inst Occupat & Social Med, Dusseldorf, Germany.
C3 Ruprecht Karls University Heidelberg; University of Amsterdam;
   University of Amsterdam; University System of Ohio; Ohio State
   University; Heinrich Heine University Dusseldorf
RP Bosch, JA (corresponding author), Univ Amsterdam, Dept Clin Psychol, Weesperpl 4, NL-1018 XA Amsterdam, Netherlands.
EM j.a.bosch@uva.nl
RI Thayer, Julian/AAA-1161-2020; Loerbroks, Adrian/IZP-5772-2023; Herr,
   Raphael/GYU-5115-2022; van Vianen, Annelies/KLC-2137-2024; Bosch,
   Jos/AAC-9408-2019; Schmidt, Burkhard/HKP-1156-2023; Jarczok, Marc
   N./A-2383-2014
OI Schmidt, Burkhard/0000-0003-2120-8014; Schmidt,
   Burkhard/0000-0001-7394-2742; Jarczok, Marc N./0000-0002-6055-385X; van
   Vianen, Annelies/0000-0002-3931-0394
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NR 96
TC 16
Z9 23
U1 1
U2 28
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0883-6612
EI 1532-4796
J9 ANN BEHAV MED
JI Ann. Behav. Med.
PD JUN
PY 2015
VL 49
IS 3
BP 434
EP 448
DI 10.1007/s12160-014-9669-9
PG 15
WC Psychology, Multidisciplinary
WE Social Science Citation Index (SSCI)
SC Psychology
GA CH7HJ
UT WOS:000354206300015
PM 25472852
OA Bronze
DA 2025-06-11
ER

PT J
AU Kerr, SMP
   Livingstone, MBE
   McCrorie, TA
   Wallace, JMW
AF Kerr, S. M. P.
   Livingstone, M. B. E.
   McCrorie, T. A.
   Wallace, J. M. W.
TI Endothelial dysfunction associated with obesity and the effect of weight
   loss interventions
SO PROCEEDINGS OF THE NUTRITION SOCIETY
LA English
DT Article; Proceedings Paper
CT Annual Irish Section Postgraduate Meeting
CY FEB 16-18, 2011
CL Univ Ulster, Derry, IRELAND
HO Univ Ulster
DE Endothelial function; Endothelial activation; Weight loss; Body
   composition
ID CORONARY-HEART-DISEASE; BODY-FAT DISTRIBUTION; ADIPOSE-TISSUE;
   CARDIOVASCULAR-DISEASE; INSULIN-RESISTANCE; RISK-FACTORS; METABOLIC
   SYNDROME; CIGARETTE-SMOKING; OXIDATIVE STRESS; ABDOMINAL FAT
AB Endothelial damage is central to the initiation and progression of atherosclerosis, while in addition vascular endothelial cells secrete several anti-atherogenic substances including the potent vasodilator nitric oxide. Increased adhesion molecule expression, in response to pathophysiological stimuli is perhaps the earliest indicator of compromised endothelial integrity. Obesity and adiposity are associated with an increased risk of CVD, influencing disease progression via a number of mechanisms, including enhanced endothelial activation. This review discusses possible mechanisms linking adiposity and more specifically regional fat depots with endothelial function and evaluates studies investigating the effect of weight loss on endothelial function, assessed by biochemical and physiological measurements. Overall, the research to date suggests that visceral adiposity is a stronger predictor of endothelial activation than overall adiposity, possibly mediated via the action of NEFA in circulation. While in general there is a suggestion that weight loss is associated with significant improvements in endothelial function, this is not apparent in all interventions and published literature to date provides less than convincing evidence for the effects of weight loss on endothelial activation.
C1 [Kerr, S. M. P.; Livingstone, M. B. E.; McCrorie, T. A.; Wallace, J. M. W.] Univ Ulster, No Ireland Ctr Food & Hlth, Coleraine BT52 1SA, Londonderry, North Ireland.
C3 Ulster University
RP Wallace, JMW (corresponding author), Univ Ulster, No Ireland Ctr Food & Hlth, Coleraine BT52 1SA, Londonderry, North Ireland.
EM j.wallace@ulster.ac.uk
RI McCaffrey, Tracy/O-7068-2017
OI McCaffrey, Tracy/0000-0001-9699-3083
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NR 60
TC 22
Z9 23
U1 0
U2 4
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0029-6651
EI 1475-2719
J9 P NUTR SOC
JI Proc. Nutr. Soc.
PD NOV
PY 2011
VL 70
IS 4
BP 418
EP 425
DI 10.1017/S0029665111001674
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Nutrition & Dietetics
GA 842PR
UT WOS:000296611900003
PM 21861950
OA Bronze
DA 2025-06-11
ER

PT J
AU Yerram, P
   Karuparthi, PR
   Hesemann, L
   Horst, J
   Whaley-Connell, A
AF Yerram, Preethi
   Karuparthi, Poorna R.
   Hesemann, Laura
   Horst, Jennifer
   Whaley-Connell, Adam
TI Chronic kidney disease and cardiovascular risk
SO JOURNAL OF THE AMERICAN SOCIETY OF HYPERTENSION
LA English
DT Review
DE Uremia-related risk factors; microalbuminuria; proteinuria;
   cardiometabolic syndrome; oxidative stress
ID C-REACTIVE PROTEIN; CHRONIC RENAL-DISEASE; METABOLIC SYNDROME; SERUM
   CREATININE; MORTALITY; PREDICTOR; OUTCOMES; EPIDEMIOLOGY; HEMODIALYSIS;
   PREVALENCE
AB Chronic kidney disease (CKD) is a global public health concern, and there is emerging a strong relationship between CKD and increased cardiovascular disease (CVD) risk. CKD in the presence of other co-morbidities such as type 2 diabetes mellitus (T2DM) and hypertension (HTN) can lead to early progression to end-stage renal disease (ESRD/stage V CKD) and confer a greater risk for CVD morbidity and mortality. CVD events are the leading cause of premature death in patients with CKD, even before their progression to ESRD, with the rate of CVD progression being twice as common compared with the general population. The higher mortality from CVD persists even after adjusting for most of the traditional risk factors, suggesting the possible contributions of uremia-related, nontraditional risk factors. This has led to the current understanding that the pathophysiology of CVD in CKD involves a complex interplay of both the traditional as well as nontraditional, uremia-related risk factors. This review will elaborate on the pathophysiology of CVD in CKD and will discuss the role of microalbuminuria (MAU)-proteinuria as a potential diagnostic and prognostic tool for CVD in CKD risk assessment. (C) 2007 American Society of Hypertension. All rights reserved.
C1 [Yerram, Preethi] Univ Missouri, Sch Med, Dept Internal Med, Hlth Sci Ctr, Columbia, MO 65212 USA.
   [Whaley-Connell, Adam] Univ Missouri, Sch Med, Div Nephrol, Columbia, MO 65212 USA.
C3 University of Missouri System; University of Missouri Columbia;
   University of Missouri System; University of Missouri Columbia
RP Yerram, P (corresponding author), Univ Missouri, Sch Med, Dept Internal Med, Hlth Sci Ctr, MA406, Columbia, MO 65212 USA.
EM yerramp@health.missouri.edu
OI Whaley-Connell, Adam/0000-0001-8955-5560; YERRAM,
   PREETHI/0000-0003-1232-4849; Hesemann, Laura/0000-0002-8743-1414
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NR 55
TC 24
Z9 26
U1 0
U2 5
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1933-1711
EI 1878-7436
J9 J AM SOC HYPERTENS
JI J. Am. Soc. Hypertens.
PD MAY-JUN
PY 2007
VL 1
IS 3
BP 178
EP 184
DI 10.1016/j.jash.2007.01.010
PG 7
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA V18KN
UT WOS:000208003800005
PM 20409850
DA 2025-06-11
ER

PT J
AU Dai, J
   Liu, ZH
   Ma, L
   Yang, CL
   Bai, LG
   Han, DD
   Song, Q
   Yan, HY
   Wang, ZQ
AF Dai, Jun
   Liu, Zihan
   Ma, Lei
   Yang, Chunliu
   Bai, Ligai
   Han, Dandan
   Song, Qi
   Yan, Hongyuan
   Wang, Zhiqiang
TI Identification of procyanidins as α-glucosidase inhibitors, pancreatic
   lipase inhibitors, and antioxidants from the bark of
   Cinnamomum cassia by multi-bioactivity-labeled molecular
   networking
SO FOOD RESEARCH INTERNATIONAL
LA English
DT Article
DE Cinnamomum cassia; Procyanidin; alpha-Glucosidase; Pancreatic lipase;
   Antioxidant; Multi-bioactivity-labeled molecular networking
ID METABOLIC SYNDROME; OXIDATIVE STRESS; IN-VITRO; A-TYPE; EXTRACT;
   PROANTHOCYANIDINS; LEAVES; COMBINATION; COMPONENTS; APPLE
AB This study examined the suppressive effects of 16 selected plant-based foods on alpha-glucosidase and pancreatic lipase and their antioxidant properties. Among these, the bark of Cinnamomum cassia (Cinnamon, WLN-FM 15) showed the highest inhibitory activity against alpha-glucosidase and the highest antioxidant activity. Additionally, WLN-FM 15 showed promising results in the other tests. To further identify the bioactive constituents of WLN-FM 15, a multi-bioactivity-labeled molecular networking approach was used through a combination of GNPS-based molecular networking, DPPH-HPLC, and affinity-based ultrafiltration-HPLC. A total of nine procyanidins were identified as antioxidants and inhibitors of alpha-glucosidase and pancreatic lipase in WLN-FM 15. Subsequently, procyanidins A1, A2, B1, and C1 were isolated, and their efficacy was confirmed through functional assays. In summary, WLN-FM 15 has the potential to serve as a functional food ingredient with the procyanidins as its bioactive constituents. These results also suggest that the multi-bioactivity-labeled molecular networking approach is reliable for identifying bioactive constituents in plant-based foods.
C1 [Dai, Jun; Liu, Zihan; Ma, Lei; Yang, Chunliu; Han, Dandan; Yan, Hongyuan; Wang, Zhiqiang] Hebei Univ, Coll Life Sci, Sch Publ Hlth, Hebei Key Lab Publ Hlth Safety, Baoding 071002, Peoples R China.
   [Bai, Ligai; Yan, Hongyuan] Hebei Univ, Coll Chem & Mat Sci, State Key Lab New Pharmaceut Preparat & Excipients, Key Lab Med Chem & Mol Diag,Minist Educ, Baoding 071002, Peoples R China.
   [Song, Qi] Hebei Univ, Coll Tradit Chinese Med, Baoding 071002, Peoples R China.
C3 Hebei University; Hebei University; Ministry of Education - China; Hebei
   University
RP Yan, HY; Wang, ZQ (corresponding author), Hebei Univ, Coll Life Sci, Sch Publ Hlth, Hebei Key Lab Publ Hlth Safety, Baoding 071002, Peoples R China.; Yan, HY (corresponding author), Hebei Univ, Coll Chem & Mat Sci, State Key Lab New Pharmaceut Preparat & Excipients, Key Lab Med Chem & Mol Diag,Minist Educ, Baoding 071002, Peoples R China.
EM yanhy@hbu.edu.cn; wangzq2017@hbu.edu.cn
RI Wang, Zhiqiang/E-9941-2018
FU National Natural Science Foundation of China [81803401, 82373634];
   Natural Science Foundation of Hebei Province [H2022201021]; Innovation
   Team Program of Hebei Univer-sity [IT2023B11]; Interdisciplinary Project
   of Hebei University [DXK202313]
FX <BOLD>Acknowledgements</BOLD> This work was supported by the National
   Natural Science Foundation of China (81803401, 82373634) , Natural
   Science Foundation of Hebei Province (H2022201021) , Innovation Team
   Program of Hebei Univer-sity (IT2023B11) , and the Interdisciplinary
   Project of Hebei University (DXK202313) .
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NR 78
TC 2
Z9 2
U1 13
U2 37
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0963-9969
EI 1873-7145
J9 FOOD RES INT
JI Food Res. Int.
PD SEP
PY 2024
VL 192
AR 114833
DI 10.1016/j.foodres.2024.114833
EA JUL 2024
PG 15
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA A8S0N
UT WOS:001285169600001
PM 39147522
DA 2025-06-11
ER

PT J
AU Abbasi, E
   Khodadadi, I
AF Abbasi, Ebrahim
   Khodadadi, Iraj
TI Antidiabetic Effects of Genistein: Mechanism of Action
SO ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS
LA English
DT Review
DE Genistein; Diabetes; isoflavone; herbal medicine; antidiabetic effects;
   insulin
ID PANCREATIC BETA-CELLS; INTESTINAL LIPOPROTEIN OVERPRODUCTION; SOY
   ISOFLAVONE SUPPLEMENTATION; ANTIOXIDANT ENZYME-ACTIVITIES;
   GUT-MICROBIOTA; INSULIN-RESISTANCE; OXIDATIVE STRESS; INFLAMMATORY
   REACTION; GLUCOSE-METABOLISM; LIPID-METABOLISM
AB Diabetes mellitus is a metabolic disease recognized by abnormal glucose level due to defects in insulin action, insulin secretion, or both. Administration of soybean and isoflavones are accompanied by a lower risk of diabetes. The present review analyzed the previous published papers related to genistein. This isoflavone, which has been used for the prevention of some chronic diseases can inhibit hepatic glucose production, increase & beta;-cell proliferation, reduce & beta;-cell apoptosis, and show potential antioxidant and anti-diabetic effects. Therefore, genistein may be useful in the management of diabetes. The beneficial effects of this isoflavone on metabolic syndrome, diabetes, cardiovascular disease, osteoporosis, and cancer have been reported in animal and human studies. Moreover, genistein reduces hepatic glucose production, normalizes hyperglycemia, and gut microbiota and exhibits potential anti-oxidative, anti-apoptotic, and hypolipidemic effects. However, studies on the underlying mechanisms of the action of genistein are very limited. Therefore, the present study reviews multifaceted aspects of genistein to reveal a possible anti-diabetic mechanism of this agent. Genistein by regulating several signaling pathways can be used for the prevention and management of diabetes.
C1 [Abbasi, Ebrahim; Khodadadi, Iraj] Hamadan Univ Med Sci, Dept Clin Biochem, Hamadan, Iran.
   [Khodadadi, Iraj] Hamadan Univ Med Sci, Fac Med, Dept Clin Biochem, Shahid Fahmideh St, Hamadan 6517838678, Iran.
C3 Hamadan University of Medical Sciences; Hamadan University of Medical
   Sciences
RP Khodadadi, I (corresponding author), Hamadan Univ Med Sci, Fac Med, Dept Clin Biochem, Shahid Fahmideh St, Hamadan 6517838678, Iran.
EM 7abbasi@gmail.com
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NR 100
TC 6
Z9 6
U1 3
U2 15
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1871-5303
EI 2212-3873
J9 ENDOCR METAB IMMUNE
JI Endocr. Metab. Immune Disord.-Drug Targets
PY 2023
VL 23
IS 13
BP 1599
EP 1610
DI 10.2174/1871530323666230516103420
EA JUL 2023
PG 12
WC Endocrinology & Metabolism; Immunology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Immunology; Pharmacology & Pharmacy
GA X3CK4
UT WOS:001041990300001
PM 37194227
DA 2025-06-11
ER

PT J
AU Magenis, ML
   de Marcos, PS
   Damiani, AP
   da Silva, ARC
   Longaretti, LM
   Franca, IB
   Da Silva, J
   Boeck, CR
   de Andrade, VM
AF Magenis, Marina Lummertz
   de Marcos, Pamela Souza
   Damiani, Adriani Paganini
   Cantareli da Silva, Anderson Ricardo
   Longaretti, Luiza Martins
   Franca, Ive Bahia
   Da Silva, Juliana
   Boeck, Carina Rodrigues
   de Andrade, Vanessa Moraes
TI Genotoxic effects of caffeine in female mice exposed during pregnancy
   and lactation period and their offspring
SO JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART C-TOXICOLOGY AND
   CARCINOGENESIS
LA English
DT Article
DE Comet assay; mutagenicity; caffeine; DNA damage; toxicity
ID OXIDATIVE STRESS; MONOSODIUM GLUTAMATE; MICRONUCLEUS ASSAY; METABOLIC
   SYNDROME; PERIPHERAL-BLOOD; DNA METHYLATION; BIRTH-WEIGHT; COMET ASSAY;
   CONSUMPTION; RISK
AB Caffeine is a widely consumed substance, and there is a discussion about its effects when ingested by women during pregnancy and lactation. We aimed to identify the genotoxic effects of caffeine in female mice that consumed it during pregnancy and lactation periods and its consequences in their offspring. Thirty-six couples of Swiss mice received water or caffeine (0.3 and 1.0 mg/mL) treatment during pregnancy and lactation. The male and female offspring were divided into 12 groups according to the treatment administered to the female mice. Genotoxicity was assessed using the comet assay and the micronucleus test. Both doses of caffeine showed genotoxic effects in pregnant and lactating mice groups compared to groups not administered caffeine. In relation to offspring, it can be observed that females and males of the offspring had low weight in early life. In both female and male offspring, genotoxicity was detected in the blood, liver, and kidney tissues. Thus, from the present study, we can suggest that the caffeine consumed by female mice during the periods of pregnancy and lactation led to genotoxic effects in their offspring.
C1 [Magenis, Marina Lummertz; de Marcos, Pamela Souza; Damiani, Adriani Paganini; Cantareli da Silva, Anderson Ricardo; Longaretti, Luiza Martins; Franca, Ive Bahia; de Andrade, Vanessa Moraes] Univ Southern Santa Catarina, Grad Program Hlth Sci, Lab Translat Biomed, Criciuma, SC, Brazil.
   [Da Silva, Juliana] Univ Luterana Brasil, Lab Genet Toxicol, Canoas, RS, Brazil.
   [Da Silva, Juliana] La Salle Univ, Canoas, RS, Brazil.
   [Boeck, Carina Rodrigues] Franciscan Univ, Grad Program Nanosci, Master Degree Hlth & Life Sci, Santa Maria, RS, Brazil.
   [de Andrade, Vanessa Moraes] Univ Southern Santa Catarina, Grad Programme Hlth Sci, Translat Biomed Lab, UNESC, 1105,Univ Rd, BR-88806000 Criciuma, SC, Brazil.
C3 Universidade do Sul de Santa Catarina; Universidade Luterana do Brasil;
   Centro Universitario La Salle; Universidade do Sul de Santa Catarina
RP de Andrade, VM (corresponding author), Univ Southern Santa Catarina, Grad Programme Hlth Sci, Translat Biomed Lab, UNESC, 1105,Univ Rd, BR-88806000 Criciuma, SC, Brazil.
EM vmoraesdeandrade@yahoo.com.br
RI Damiani, Adriani/N-8007-2018; Ricardo Cantareli da Silva,
   Anderson/IRZ-0814-2023; Andrade, Vanessa/F-9623-2012; da Silva,
   Juliana/J-8996-2012; Boeck, Carina/E-9472-2011
OI Ricardo Cantareli da Silva, Anderson/0000-0003-1371-6991; Lummertz
   Magenis, Marina/0000-0003-4564-809X; da Silva,
   Juliana/0000-0002-1089-6766; Boeck, Carina/0000-0002-6828-5634
FU Santa Catarina Research and Innovation Support Foundation
   [2021TR000672-FAPESC/2021]
FX This work was supported by the Santa Catarina Research and Innovation
   Support Foundation (2021TR000672-FAPESC/2021).
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NR 88
TC 0
Z9 0
U1 4
U2 19
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 2689-6583
EI 2689-6591
J9 J ENV SCI HEAL C-TOX
JI J. Environ. Sci. Health Part C-Toxicol. Carcinogen.
PD APR 3
PY 2023
VL 41
IS 1-2
BP 36
EP 60
DI 10.1080/26896583.2023.2213613
EA MAY 2023
PG 25
WC Oncology; Environmental Sciences; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Environmental Sciences & Ecology; Toxicology
GA K3EZ6
UT WOS:000996002200001
PM 37243358
DA 2025-06-11
ER

PT J
AU Flessa, CM
   Nasiri-Ansari, N
   Kyrou, I
   Leca, BM
   Lianou, M
   Chatzigeorgiou, A
   Kaltsas, G
   Kassi, E
   Randeva, HS
AF Flessa, Christina-Maria
   Nasiri-Ansari, Narjes
   Kyrou, Ioannis
   Leca, Bianca M.
   Lianou, Maria
   Chatzigeorgiou, Antonios
   Kaltsas, Gregory
   Kassi, Eva
   Randeva, Harpal S.
TI Genetic and Diet-Induced Animal Models for Non-Alcoholic Fatty Liver
   Disease (NAFLD) Research
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE non-alcoholic fatty liver disease; NAFLD; non-alcoholic steatohepatitis;
   NASH; animal models; mouse; cirrhosis
ID SPONTANEOUS METABOLIC SYNDROME; CHOLINE-DEFICIENT DIET; MOUSE MODEL;
   HEPATOCELLULAR-CARCINOMA; OXIDATIVE STRESS; HIGH-FRUCTOSE; MURINE MODEL;
   CAUSES STEATOHEPATITIS; HEPATIC INFLAMMATION; INSULIN-RESISTANCE
AB A rapidly increasing incidence of non-alcoholic fatty liver disease (NAFLD) is noted worldwide due to the adoption of western-type lifestyles and eating habits. This makes the understanding of the molecular mechanisms that drive the pathogenesis of this chronic disease and the development of newly approved treatments of utmost necessity. Animal models are indispensable tools for achieving these ends. Although the ideal mouse model for human NAFLD does not exist yet, several models have arisen with the combination of dietary interventions, genetic manipulations and/or administration of chemical substances. Herein, we present the most common mouse models used in the research of NAFLD, either for the whole disease spectrum or for a particular disease stage (e.g., non-alcoholic steatohepatitis). We also discuss the advantages and disadvantages of each model, along with the challenges facing the researchers who aim to develop and use animal models for translational research in NAFLD. Based on these characteristics and the specific study aims/needs, researchers should select the most appropriate model with caution when translating results from animal to human.
C1 [Flessa, Christina-Maria; Nasiri-Ansari, Narjes; Lianou, Maria; Kassi, Eva] Natl & Kapodistrian Univ Athens, Med Sch, Dept Biol Chem, Athens 11527, Greece.
   [Flessa, Christina-Maria; Kyrou, Ioannis; Leca, Bianca M.; Randeva, Harpal S.] Univ Hosp Coventry & Warwickshire NHS Trust, Warwickshire Inst Study Diabet Endocrinol & Metab, Coventry CV2 2DX, England.
   [Kyrou, Ioannis; Randeva, Harpal S.] Univ Warwick, Warwick Med Sch, Coventry CV4 7AL, England.
   [Kyrou, Ioannis] Coventry Univ, Res Inst Hlth & Wellbeing, Coventry CV1 5FB, England.
   [Kyrou, Ioannis] Aston Univ, Coll Hlth & Life Sci, Aston Med Sch, Birmingham B4 7ET, England.
   [Kyrou, Ioannis] Agr Univ Athens, Sch Food & Nutr Sci, Dept Food Sci & Human Nutr, Lab Dietet & Qual Life, Athens 11855, Greece.
   [Chatzigeorgiou, Antonios] Natl & Kapodistrian Univ Athens, Med Sch, Dept Physiol, Athens 11527, Greece.
   [Kaltsas, Gregory; Kassi, Eva] Natl & Kapodistrian Univ Athens, Laiko Hosp, Dept Propaedeut Internal Med 1, Endocrine Unit, Athens 11527, Greece.
C3 National & Kapodistrian University of Athens; University of Warwick;
   University of Warwick; Coventry University; Aston University;
   Agricultural University of Athens; National & Kapodistrian University of
   Athens; Laiko General Hospital; National & Kapodistrian University of
   Athens
RP Kassi, E (corresponding author), Natl & Kapodistrian Univ Athens, Med Sch, Dept Biol Chem, Athens 11527, Greece.; Randeva, HS (corresponding author), Univ Hosp Coventry & Warwickshire NHS Trust, Warwickshire Inst Study Diabet Endocrinol & Metab, Coventry CV2 2DX, England.; Kassi, E (corresponding author), Natl & Kapodistrian Univ Athens, Laiko Hosp, Dept Propaedeut Internal Med 1, Endocrine Unit, Athens 11527, Greece.
EM ekassi@med.uoa.gr; harpal.randeva@uhcw.nhs.uk
RI Leca, Bianca/KYQ-7891-2024; Chatzigeorgiou, Antonios/G-1581-2010
OI Nasiri Ansari, Narjes/0000-0002-0116-693X; FLESSA,
   CHRISTINA-MARIA/0000-0003-2915-6386; Leca, Bianca/0000-0002-6094-3313;
   Chatzigeorgiou, Antonios/0000-0002-7039-4223
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NR 161
TC 57
Z9 59
U1 6
U2 40
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD DEC
PY 2022
VL 23
IS 24
AR 15791
DI 10.3390/ijms232415791
PG 34
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 7E4GK
UT WOS:000901128500001
PM 36555433
OA Green Published, gold, Green Accepted
DA 2025-06-11
ER

PT J
AU Manivannan, A
   Lee, ES
   Han, K
   Lee, HE
   Kim, D
AF Manivannan, Abinaya
   Lee, Eun-Su
   Han, Koeun
   Lee, Hye-Eun
   Kim, Do-Sun
TI Versatile Nutraceutical Potentials of Watermelon-A Modest Fruit Loaded
   with Pharmaceutically Valuable Phytochemicals
SO MOLECULES
LA English
DT Review
DE anti-cancer; anti-diabetic; functional food; l-citrulline; lycopene;
   obesity; polyphenols
ID L-ARGININE SUPPLEMENTATION; INFLAMMATORY-BOWEL-DISEASE; CELL-CYCLE
   PROGRESSION; ULCERATIVE-COLITIS; DIETARY SUPPLEMENTATION; METABOLIC
   SYNDROME; OXIDATIVE STRESS; BY-PRODUCT; LYCOPENE; CANCER
AB Watermelon (Citrulus lantus) is an important horticultural crop which belongs to the Curcubitaceae family. The nutraceutical potential of watermelon has been illustrated by several researchers, which makes it a better choice of functional food. Watermelon has been used to treat various ailments, such as cardio-vascular diseases, aging related ailments, obesity, diabetes, ulcers, and various types of cancers. The medicinal properties of watermelon are attributed by the presence of important phytochemicals with pharmaceutical values such as lycopene, citrulline, and other polyphenolic compounds. Watermelon acts as vital source of l-citrulline, a neutral-alpha amino acid which is the precursor of l-arginine, an essential amino acid necessary for protein synthesis. Supplementation of l-citrulline and lycopene displayed numerous health benefits in in vitro and in vivo studies. Similarly, the dietary intake of watermelon has proven benefits as functional food in humans for weight management. Apart from the fruits, the extracts prepared from the seeds, sprouts, and leaves also evidenced medicinal properties. The present review provides a comprehensive overview of benefits of watermelon for the treatment of various ailments.
C1 [Manivannan, Abinaya; Lee, Eun-Su; Han, Koeun; Lee, Hye-Eun; Kim, Do-Sun] Rural Dev Adm, Natl Inst Hort & Herbal Sci, Vegetable Res Div, Jeonju 55365, South Korea.
C3 National Institute of Horticultural & Herbal Science (NIHHS), Republic
   of Korea; Rural Development Administration (RDA), Republic of Korea
RP Kim, D (corresponding author), Rural Dev Adm, Natl Inst Hort & Herbal Sci, Vegetable Res Div, Jeonju 55365, South Korea.
EM abinaya@korea.kr; lus4434@korea.kr; hke1221@korea.kr; helee72@korea.kr;
   greenever@korea.kr
RI Manivannan, Ayyakkannu/AAD-1464-2019; Lee, HyeEun/LZG-8579-2025
OI Manivannan, Abinaya/0000-0003-2725-410X
FU National Institute of Horticultural& Herbal Science, Rural Development
   Administration, Republic of Korea [PJ01417301]; RDA Research Associate
   Fellowship Program of National Institute of Horticultural and Herbal
   Science, Rural Development Administration, Republic of Korea
FX This study was supported by the National Institute of Horticultural&
   Herbal Science, Rural Development Administration, Republic of Korea
   (Project No. PJ01417301). Abinaya Manivannan was supported by the RDA
   Research Associate Fellowship Program of National Institute of
   Horticultural and Herbal Science, Rural Development Administration,
   Republic of Korea.
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NR 111
TC 44
Z9 49
U1 0
U2 30
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1420-3049
J9 MOLECULES
JI Molecules
PD NOV
PY 2020
VL 25
IS 22
AR 5258
DI 10.3390/molecules25225258
PG 15
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA OY2WT
UT WOS:000594112300001
PM 33187365
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Liu, M
   Tan, JJ
   He, ZY
   He, X
   Hou, DX
   He, JH
   Wu, SS
AF Liu, Ming
   Tan, Jijun
   He, Ziyu
   He, Xi
   Hou, De-Xing
   He, Jianhua
   Wu, Shusong
TI Inhibitory effect of blue honeysuckle extract on high-fat-diet-induced
   fatty liver in mice
SO ANIMAL NUTRITION
LA English
DT Article
DE Blue honeysuckle; Polyphenols; Fatty liver; Lipid peroxidation;
   Antioxidant
ID INDUCED INFLAMMATION; PATHOGENESIS; POLYPHENOLS; ACTIVATION; CROSSTALK;
   CULTIVARS; FIBROSIS; PATHWAY; SYSTEM; DAMAGE
AB Blue honeysuckle is rich in polyphenols, and recently receiving attention because of its potential antioxidant and anti-inflammatory properties. Nonalcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease that develops hepatic inflammation and metabolic syndrome. The present study aims to study the effect of blue honeysuckle extract (BHE) on fat deposition and hepatic lipid peroxidation in a high-fat-diet (HFD)-induced mouse model. Mice were fed a normal diet (ND) or a HFD containing 0.5% or 1% of BHE or not for 45 d. Liver sections were stained by hematoxylin-eosin staining. Serum lipids were measured by a clinical analyzer. Insulin was examined by ELISA, and hepatic proteins were detected by Western blotting. Dietary supplementation of BHE dose-dependently suppressed HFD-induced obesity and hepatic fat deposition. Moreover, BHE improved glucose metabolism by increasing insulin sensitivity and attenuated oxidative stress potentially by up-regulating nuclear factor (erythroid-derived 2)-like 2 (Nrf2)-mediated pathway. (C) 2018, Chinese Association of Animal Science and Veterinary Medicine. Production and hosting by Elsevier B.V. on behalf of KeAi Communications Co., Ltd.
C1 [Liu, Ming; Tan, Jijun; He, Ziyu; He, Xi; Hou, De-Xing; He, Jianhua; Wu, Shusong] Hunan Agr Univ, Hunan Collaborat Innovat Ctr Utilizat Bot Funct I, Core Res Program 1515, Changsha 410128, Hunan, Peoples R China.
   [Hou, De-Xing] Kagoshima Univ, United Grad Sch Agr Sci, Kagoshima 8900065, Japan.
C3 Hunan Agricultural University; Kagoshima University
RP He, JH; Wu, SS (corresponding author), Hunan Agr Univ, Hunan Collaborat Innovat Ctr Utilizat Bot Funct I, Core Res Program 1515, Changsha 410128, Hunan, Peoples R China.
EM jianhuahy@hunau.net; wush688@126.com
RI Hou, De-Xing/C-9296-2011; Wu, Shusong/L-9807-2019; JIANHUA,
   HE/G-3340-2014
OI He, Jianhua/0000-0002-9289-4405; Hou, De-Xing/0000-0002-0449-8331
FU National Natural Science Foundation of China [31741115]; Core Research
   Program of Hunan Agricultural University [1515]
FX This work was partially supported by National Natural Science Foundation
   of China (No. 31741115) and Core Research Program 1515 of Hunan
   Agricultural University.
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NR 30
TC 31
Z9 37
U1 6
U2 67
PU KEAI PUBLISHING LTD
PI BEIJING
PA 16 DONGHUANGCHENGGEN NORTH ST, BEIJING, DONGHENG DISTRICT 100717,
   PEOPLES R CHINA
SN 2405-6383
EI 2405-6545
J9 ANIM NUTR
JI Anim. Nutr.
PD SEP
PY 2018
VL 4
IS 3
BP 288
EP 293
DI 10.1016/j.aninu.2018.06.001
PG 6
WC Agriculture, Dairy & Animal Science; Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture; Veterinary Sciences
GA GT5AJ
UT WOS:000444518000008
PM 30175257
OA Green Published, gold
DA 2025-06-11
ER

PT S
AU Makarem, N
   Bandera, EV
   Nicholson, JM
   Parekh, N
AF Makarem, Nour
   Bandera, Elisa V.
   Nicholson, Joseph M.
   Parekh, Niyati
BE Stover, PJ
   Balling, R
TI Consumption of Sugars, Sugary Foods, and Sugary Beverages in Relation to
   Cancer Risk: A Systematic Review of Longitudinal Studies
SO ANNUAL REVIEW OF NUTRITION, VOL 38
SE Annual Review of Nutrition
LA English
DT Review; Book Chapter
DE systematic review; prospective studies; sugars; sugary foods and
   beverages; cancer risk
ID DIETARY GLYCEMIC LOAD; PANCREATIC-CANCER; ENDOMETRIAL CANCER;
   COLORECTAL-CANCER; CARBOHYDRATE INTAKE; BREAST-CANCER; SWEETENED
   BEVERAGES; METABOLIC SYNDROME; PHYSICAL-ACTIVITY; COLON-CANCER
AB High sugar intake may increase cancer risk by promoting insulin-glucose dysregulation, oxidative stress, inflammation, and body adiposity, but epidemiologic evidence is unclear. Associations between dietary sugars and lifestyle-related cancer risk from longitudinal studies were evaluated. We systematically searched PubMed, Embase, and CINAHL and identified 37 prospective cohort studies (1990-2017) reporting multivariable adjusted risk estimates for dietary sugars in relation to cancer. Of 15 and 14 studies on total sugar and sucrose respectively, 11 reported a null association in relation to cancer. Of 14 studies on fructose, 8 reported null associations, and 2 reported protective and 4 reported detrimental associations. In two of five studies on added sugars, a 60-95% increased cancer risk was observed with higher intakes. In 8 of 15 studies on sugary foods and beverages, a 23-200% higher cancer risk was observed with higher sugary beverage consumption. In conclusion, most studies were indicative of a null association, but suggestive detrimental associations were reported for added sugars and sugary beverages.
C1 [Makarem, Nour] Columbia Univ, Med Ctr, Dept Med, New York, NY 10032 USA.
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   [Bandera, Elisa V.] Rutgers Canc Inst New Jersey, New Brunswick, NJ 08903 USA.
   [Nicholson, Joseph M.] NYU, Sch Med, Hlth Sci Lib, New York, NY 10016 USA.
   [Parekh, Niyati] NYU, Coll Global Publ Hlth, 550 1st Ave, New York, NY 10003 USA.
   [Parekh, Niyati] NYU, Dept Populat Hlth, Langone Hlth, 550 1st Ave, New York, NY 10016 USA.
C3 Columbia University; Rutgers University System; Rutgers University New
   Brunswick; Rutgers University System; Rutgers University New Brunswick;
   Rutgers University Biomedical & Health Sciences; Rutgers Cancer
   Institute of New Jersey; New York University; New York University; New
   York University
RP Makarem, N (corresponding author), Columbia Univ, Med Ctr, Dept Med, New York, NY 10032 USA.
EM nm2968@cumc.columbia.edu; banderel@cinj.rutgers.edu;
   Joseph.Nicholson@med.nyu.edu; niyati.parekh@nyu.edu
RI Bandera, Elisa/M-4169-2014; Nicholson, Joey/AAG-6421-2019; Makarem,
   Nour/JTU-0953-2023; Parekh, Niyati/ABF-4933-2020
OI parekh, niyati/0000-0002-1334-0528; Nicholson, Joey/0000-0001-8658-5879
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NR 76
TC 84
Z9 89
U1 1
U2 41
PU ANNUAL REVIEWS
PI PALO ALTO
PA 4139 EL CAMINO WAY, PO BOX 10139, PALO ALTO, CA 94303-0897 USA
SN 0199-9885
EI 1545-4312
BN 978-0-8243-2828-3
J9 ANNU REV NUTR
JI Annu. Rev. Nutr.
PY 2018
VL 38
BP 17
EP 39
DI 10.1146/annurev-nutr-082117-051805
PG 23
WC Nutrition & Dietetics
WE Book Citation Index – Science (BKCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA BK8WF
UT WOS:000443931300002
PM 29801420
OA Bronze
DA 2025-06-11
ER

PT J
AU Wester, VL
   Staufenbiel, SM
   Veldhorst, MAB
   Visser, JA
   Manenschijn, L
   Koper, JW
   Klessens-Godfroy, FJM
   van den Akker, ELT
   van Rossum, EFC
AF Wester, Vincent L.
   Staufenbiel, Sabine M.
   Veldhorst, Margriet A. B.
   Visser, Jenny A.
   Manenschijn, Laura
   Koper, Jan W.
   Klessens-Godfroy, Francoise J. M.
   van den Akker, Erica L. T.
   van Rossum, Elisabeth F. C.
TI Long-Term Cortisol Levels Measured in Scalp Hair of Obese Patients
SO OBESITY
LA English
DT Article
ID METABOLIC SYNDROME; CUSHINGS-SYNDROME; DIAGNOSIS; STRESS; STATEMENT;
   EXPOSURE
AB Objective: In obese subjects a relatively high cortisol output in urine has been observed compared to nonobese individuals. However, cortisol levels in blood, saliva, and urine in association with obesity have been inconsistent across studies, possibly due to the high variability of systemic cortisol levels. Cortisol levels measured in scalp hair provide a marker for long-term cortisol exposure, and have been associated with cardiovascular disease in an elderly population and to disease course in Cushing's disease. We aimed to compare hair cortisol levels between obese patients and nonobese controls.
   Methods: Hair cortisol levels of 47 obese patients (median BMI 38.8, range 31.1-65.8), 41 overweight, and 87 normal-weight subjects using an enzyme-linked immunosorbent assay (ELISA) were measured.
   Results: Obese patients had higher hair cortisol levels than overweight and normal weight subjects (respectively 30.8 vs 8.5 and 8.4 pg/mg hair, P < 0.001). No significant difference in hair cortisol levels was found between normal weight and overweight subjects.
   Conclusions: Our results suggest a higher long-term cortisol exposure in obese patients, which may contribute to cardiovascular disease risk. Future research will determine whether long-term cortisol levels provide a novel treatment target in the management of cardiovascular disease risk in obesity.
C1 [Wester, Vincent L.; Staufenbiel, Sabine M.; Visser, Jenny A.; Manenschijn, Laura; Koper, Jan W.; van Rossum, Elisabeth F. C.] Univ Med Ctr Rotterdam, Erasmus MC, Dept Internal Med, Rotterdam, Netherlands.
   [Wester, Vincent L.; Staufenbiel, Sabine M.; Veldhorst, Margriet A. B.; Visser, Jenny A.; Manenschijn, Laura; Koper, Jan W.; Klessens-Godfroy, Francoise J. M.; van den Akker, Erica L. T.; van Rossum, Elisabeth F. C.] Univ Med Ctr Rotterdam, Erasmus MC, Obes Ctr CGG, Rotterdam, Netherlands.
   [Wester, Vincent L.; Staufenbiel, Sabine M.; Veldhorst, Margriet A. B.; Visser, Jenny A.; Manenschijn, Laura; Koper, Jan W.; Klessens-Godfroy, Francoise J. M.; van den Akker, Erica L. T.; van Rossum, Elisabeth F. C.] Sint Franciscus Hosp, Rotterdam, Netherlands.
   [Veldhorst, Margriet A. B.; van den Akker, Erica L. T.] Univ Med Ctr Rotterdam, Erasmus MC, Dept Pediat, Rotterdam, Netherlands.
   [Klessens-Godfroy, Francoise J. M.] Sint Franciscus Hosp, Dept Internal Med, Rotterdam, Netherlands.
C3 Erasmus University Rotterdam; Erasmus MC; Erasmus University Rotterdam;
   Erasmus MC; Franciscus Gasthuis; Erasmus University Rotterdam; Erasmus
   MC; Franciscus Gasthuis
RP van Rossum, EFC (corresponding author), Univ Med Ctr Rotterdam, Erasmus MC, Dept Internal Med, Rotterdam, Netherlands.
EM e.vanrossum@erasmusmc.nl
RI Akker, Erica/I-7624-2012; Visser, Jenny/F-8156-2011; van Rossum,
   Elisabeth/AAP-9388-2020
OI van Rossum, Elisabeth/0000-0003-0120-4913; Wester,
   Vincent/0000-0002-0971-2739
FU Netherlands Organisation for Scientific Research (NWO) [916.96.069]
FX This work was supported by the Netherlands Organisation for Scientific
   Research (NWO) grant number 916.96.069.
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NR 17
TC 72
Z9 85
U1 1
U2 29
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1930-7381
EI 1930-739X
J9 OBESITY
JI Obesity
PD SEP
PY 2014
VL 22
IS 9
BP 1956
EP 1958
DI 10.1002/oby.20795
PG 3
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA AO8BR
UT WOS:000341578000005
PM 24852462
OA Bronze
DA 2025-06-11
ER

PT J
AU Hassan, W
   Ding, L
   Gao, RY
   Liu, J
   Shang, J
AF Hassan, Waseem
   Ding, Lin
   Gao, Rong-Yin
   Liu, Jun
   Shang, Jing
TI Interleukin-6 signal transduction and its role in hepatic lipid
   metabolic disorders
SO CYTOKINE
LA English
DT Review
DE Interleukin-6 (IL-6); Metabolic disease
ID ACTIVATED PROTEIN-KINASE; FATTY LIVER-DISEASE; ANTI-INTERLEUKIN-6
   RECEPTOR ANTIBODY; AMELIORATES INSULIN-RESISTANCE; INDUCED OXIDATIVE
   STRESS; CORONARY-HEART-DISEASE; STIMULATORY FACTOR-II; C-REACTIVE
   PROTEIN; RHEUMATOID-ARTHRITIS; T-CELLS
AB Hepatic lipid dysregulation can lead to spectrum of metabolic disease conditions including metabolic syndrome (MS), fatty liver and diabetes. Liver lipids are regulated by a complex set of extra-hepatic and intra-hepatic factors including cellular cross-talk with variety of cells, inducing various cytokines. Interleukin 6 (IL-6) is a pleiotropic cytokine that exerts both pro-inflammatory and anti-inflammatory effects on hepatic system through either JNK/STAT or ERK/MAPK signaling. Although, IL-6 has shown to protect the liver from fat storage in both rodent and human models and various IL-6(-/-) studies have supported this notion yet a question remains over its deleterious pro-inflammatory effects on hepatocytes. IL-6 ability to produce reactive oxygen species (ROS) and subsequently disturb the hepatic lipid balance has created a conundrum. Furthermore, IL-6 has shown to behave differently under different disease states within hepatocytes and hence, modulating the hepatic lipids accordingly. This review deals with the role of IL-6 on hepatic lipid metabolism and analyzes various data presented on this topic. (c) 2014 Elsevier Ltd. All rights reserved.
C1 China Pharmaceut Univ, Natl Ctr Drug Screening, Nanjing 210009, Jiangsu, Peoples R China.
   China Pharmaceut Univ, State Key Lab Nat Med, Nanjing 210009, Jiangsu, Peoples R China.
C3 China Pharmaceutical University; China Pharmaceutical University
RP Shang, J (corresponding author), China Pharmaceut Univ, 24 Tongjiaxiang, Nanjing 210009, Jiangsu, Peoples R China.
EM shangjing21cn@163.com
RI Hassan, Waseem/AAD-1170-2019
OI Hassan, Waseem/0000-0002-0197-1736
FU National Science and Technology Infrastructure Program of China
   [2012BAI30B001]; Mega-projects of Science Research for the 12th Five
   Year Plan of China [2011ZX09401007]; Project Program of State Key
   Laboratory of Natural Medicines, China Pharmaceutical University
   [JKGZ201108]; Jiangsu Yanjiushengchuangxin Plan [CXLX11-0782]
FX This study was supported by "National Science and Technology
   Infrastructure Program of China" (2012BAI30B001), "Mega-projects of
   Science Research for the 12th Five Year Plan of China" (2011ZX09401007),
   "Project Program of State Key Laboratory of Natural Medicines, China
   Pharmaceutical University (JKGZ201108) and "Jiangsu Yanjiushengchuangxin
   Plan" (CXLX11-0782).
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TC 39
Z9 46
U1 1
U2 28
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 1043-4666
EI 1096-0023
J9 CYTOKINE
JI Cytokine
PD APR
PY 2014
VL 66
IS 2
BP 133
EP 142
DI 10.1016/j.cyto.2013.12.017
PG 10
WC Biochemistry & Molecular Biology; Cell Biology; Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology; Immunology
GA AE1KW
UT WOS:000333729200007
PM 24491813
DA 2025-06-11
ER

PT J
AU Pipitone, RM
   Ciccioli, C
   Infantino, G
   La Mantia, C
   Parisi, S
   Tulone, A
   Pennisi, G
   Grimaudo, S
   Petta, S
AF Pipitone, Rosaria Maria
   Ciccioli, Carlo
   Infantino, Giuseppe
   La Mantia, Claudia
   Parisi, Stefanie
   Tulone, Adele
   Pennisi, Grazia
   Grimaudo, Stefania
   Petta, Salvatore
TI MAFLD: a multisystem disease
SO THERAPEUTIC ADVANCES IN ENDOCRINOLOGY AND METABOLISM
LA English
DT Review
DE fatty liver; MAFLD; NAFLD
ID FATTY LIVER-DISEASE; EXOME-WIDE ASSOCIATION; CHRONIC KIDNEY-DISEASE;
   CARDIOVASCULAR-DISEASE; CONFERS SUSCEPTIBILITY; METABOLIC SYNDROME;
   FIBROSIS SCORE; CANCER-RISK; PNPLA3; SEVERITY
AB Nonalcoholic fatty liver disease (NAFLD), affecting about 25% of general population and more than 50% of dysmetabolic patients, is an emerging cause of chronic liver disease and its complications. Recently, an international consensus of experts proposed to rename this disease as 'Metabolic dysfunction-Associated Fatty Liver Disease' (MAFLD) to focus on the bidirectional interplay between fatty liver and metabolic alterations and to stress the need of assessing fatty liver independently from alcohol consumption and other coexisting causes of liver disease. The peculiarity of NAFLD/MAFLD lies in the presence of a higher risk of not only - as expected - liver-related events but also of extrahepatic events, mostly cardiovascular and cancers. Available evidence suggests that these associations are not only the expression of sharing the same risk factors but shed light about the ability of NAFLD/MAFLD and particularly of its progressive form - nonalcoholic/metabolic dysfunction-associated steatohepatitis - to act as an independent risk factor via promotion of atherogenic dyslipidemia and a proinflammatory, profibrogenic, and procoagulant systemic environment. The present review summarizes available epidemiological and clinical evidence supporting the concept of NAFLD/MAFLD as a multisystemic disease, and highlights potential explanatory mechanisms underlying the association between NAFLD/MAFLD and extrahepatic disorders.
C1 [Petta, Salvatore] Univ Palermo, Sez Gastroenterol & Epatol Di Bi MIS, Piazza Clin 2, I-90127 Palermo, Italy.
   [Pipitone, Rosaria Maria; Ciccioli, Carlo; Infantino, Giuseppe; La Mantia, Claudia; Parisi, Stefanie; Tulone, Adele; Pennisi, Grazia; Grimaudo, Stefania; Petta, Salvatore] Univ Palermo, Sect Gastroenterol & Hepatol, PROMISE, Palermo, Italy.
C3 University of Palermo; University of Palermo
RP Petta, S (corresponding author), Univ Palermo, Sez Gastroenterol & Epatol Di Bi MIS, Piazza Clin 2, I-90127 Palermo, Italy.; Petta, S (corresponding author), Univ Palermo, Sect Gastroenterol & Hepatol, PROMISE, Palermo, Italy.
EM salvatore.petta@unipa.it
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NR 121
TC 100
Z9 101
U1 18
U2 59
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 2042-0188
EI 2042-0196
J9 THER ADV ENDOCRINOL
JI Ther. Adv. Endocrinol. Metab.
PY 2023
VL 14
AR 20420188221145549
DI 10.1177/20420188221145549
PG 23
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA R0CU0
UT WOS:001061111700001
PM 36726391
OA Green Published, gold
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Couvineau, A
   Nicole, P
   Gratio, V
   Voisin, T
AF Couvineau, Alain
   Nicole, Pascal
   Gratio, Valerie
   Voisin, Thierry
TI The Orexin receptors: Structural and anti-tumoral properties
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Review
DE G protein-coupled receptor(GPCR); protein structure; pharmacology;
   structure-function relationship; cancer; Orexins; Orexin receptor
ID PROTEIN-COUPLED RECEPTORS; NEUROPEPTIDE; ANTAGONISTS; CANCER; SLEEP;
   EXPRESSION; OX1; NARCOLEPSY; PHYSIOLOGY; APOPTOSIS
AB At the end of the 20th century, two new neuropeptides (Orexin-A/hypocretin-1 and Orexin-B/hypocretins-2) expressed in hypothalamus as a prepro-orexins precursor, were discovered. These two neuropeptides interacted with two G protein-coupled receptor isoforms named OX1R and OX2R. The orexins/OX receptors system play an important role in the central and peripheral nervous system where it controls wakefulness, addiction, reward seeking, stress, motivation, memory, energy homeostasis, food intake, blood pressure, hormone secretions, reproduction, gut motility and lipolysis. Orexins and their receptors are involved in pathologies including narcolepsy type I, neuro- and chronic inflammation, neurodegenerative diseases, metabolic syndrome, and cancers. Associated with these physiopathological roles, the extensive development of pharmacological molecules including OXR antagonists, has emerged in association with the determination of the structural properties of orexins and their receptors. Moreover, the identification of OX1R expression in digestive cancers encompassing colon, pancreas and liver cancers and its ability to trigger mitochondrial apoptosis in tumoral cells, indicate a new putative therapeutical action of orexins and paradoxically OXR antagonists. The present review focuses on structural and anti-tumoral aspects of orexins and their receptors.
C1 [Couvineau, Alain; Nicole, Pascal; Gratio, Valerie; Voisin, Thierry] Univ Paris Cite, Ctr Res Inflammat CRI, Team From Inflammat Canc Digest Dis, INSERM UMR S1149,DHU UNITY, Paris, France.
C3 Universite Paris Cite; Institut National de la Sante et de la Recherche
   Medicale (Inserm)
RP Couvineau, A (corresponding author), Univ Paris Cite, Ctr Res Inflammat CRI, Team From Inflammat Canc Digest Dis, INSERM UMR S1149,DHU UNITY, Paris, France.
EM alain.couvineau@inserm.fr
RI Gratio, Valerie/MBI-1099-2025; couvineau, alain/G-3641-2013
OI Gratio, Valerie/0000-0001-8563-3293
FU "Institut National de la Sante et de la Recherche Medicale" (INSERM);
   Universite Paris Cite; Institut National du Cancer (INCA) [PAIR
   Pancreas] [PAN18-045]; Ligue Nationale Contre le Cancer [R16020HH,
   GB/MA/CD/EP-12062]
FX Funding Our work was supported by the "Institut National de la Sante et
   de la Recherche Medicale" (INSERM), the "Universite Paris Cite", The
   "Institut National du Cancer (INCA)" [PAIR Pancreas, grant number N
   PAN18-045] and the "Ligue Nationale Contre le Cancer" [grant numbers
   R16020HH, GB/MA/CD/EP-12062].
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NR 87
TC 19
Z9 19
U1 1
U2 15
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD JUL 28
PY 2022
VL 13
AR 931970
DI 10.3389/fendo.2022.931970
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 3R5RP
UT WOS:000838970000001
PM 35966051
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Gleeson, M
   McNicholas, WT
AF Gleeson, Margaret
   McNicholas, Walter T.
TI Bidirectional relationships of comorbidity with obstructive sleep apnoea
SO EUROPEAN RESPIRATORY REVIEW
LA English
DT Review
ID POSITIVE AIRWAY PRESSURE; CHRONIC KIDNEY-DISEASE; NOCTURNAL
   BLOOD-PRESSURE; HEART-FAILURE; INTERMITTENT HYPOXIA; CARDIOVASCULAR
   OUTCOMES; DAYTIME SLEEPINESS; GLUCOSE-METABOLISM; PULMONARY-DISEASE;
   OXIDATIVE STRESS
AB Obstructive sleep apnoea (OSA) is frequently associated with comorbidities that include metabolic, cardiovascular, renal, pulmonary and neuropsychiatric. There is considerable evidence that OSA is an independent risk factor for many of these comorbidities but, more recently, there is evidence that some of these comorbidities may predispose to the development of OSA. Thus, there is growing evidence of a bidirectional relationship between OSA and comorbidity, especially for heart failure, metabolic syndrome and stroke. Potential mechanisms of bidirectional relationships differ in individual comorbidities with fluid retention and redistribution being especially important in heart failure and end-stage renal disease, whereas neural mechanisms may be more important in diabetes mellitus and stroke. The evidence for other comorbidities, such as hypertension and atrial fibrillation, support these being more a consequence of OSA with limited evidence to support a bidirectional relationship. The present review explores the evidence for such bidirectional relationships with a particular perspective on comorbidities that may predispose to OSA. The impact of therapy in bidirectional relationships is also reviewed, which highlights the clinical importance of accurate diagnosis. This aspect is especially true of COPD, where the identification of coexisting OSA has important implications for optimum therapy.
C1 [McNicholas, Walter T.] Univ Coll Dublin, Sch Med, Dublin, Ireland.
   St Vincents Hosp Grp, Dept Resp & Sleep Med, Dublin, Ireland.
C3 University College Dublin
RP McNicholas, WT (corresponding author), Univ Coll Dublin, Sch Med, Dublin, Ireland.
EM walter.mcnicholas@ucd.ie
OI McNicholas, Walter/0000-0001-5927-2738
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NR 135
TC 102
Z9 107
U1 13
U2 47
PU EUROPEAN RESPIRATORY SOC JOURNALS LTD
PI SHEFFIELD
PA 442 GLOSSOP RD, SHEFFIELD S10 2PX, ENGLAND
SN 0905-9180
EI 1600-0617
J9 EUR RESPIR REV
JI Eur. Respir. Rev.
PD JUN 30
PY 2022
VL 31
IS 164
AR 210256
DI 10.1183/16000617.0256-2021
PG 15
WC Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Respiratory System
GA 1I8ET
UT WOS:000797460400002
PM 35508332
OA gold, Green Published
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Esler, WP
   Bence, KK
AF Esler, William P.
   Bence, Kendra K.
TI Metabolic Targets in Nonalcoholic Fatty Liver Disease
SO CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
LA English
DT Review
ID GROWTH-FACTOR 21; RECEPTOR-BETA AGONIST; COA CARBOXYLASE INHIBITORS;
   TISSUE INSULIN-RESISTANCE; HEPATIC STEATOSIS; DIACYLGLYCEROL
   ACYLTRANSFERASE; CARDIOVASCULAR OUTCOMES; OXIDATIVE STRESS; ACID
   OXIDATION; MOUSE MODELS
AB The prevalence and diagnosis of nonalcoholic fatty liver disease (NAFLD) is on the rise worldwide and currently has no FDA-approved pharmacotherapy. The increase in disease burden of NAFLD and a more severe form of this progressive liver disease, nonalcoholic steatohepatitis (NASH), largely mirrors the increase in obesity and type 2 diabetes (T2D) and reflects the hepatic manifestation of an altered metabolic state. Indeed, metabolic syndrome, defined as a constellation of obesity, insulin resistance, hyperglycemia, dyslipidemia and hypertension, is the major risk factor predisposing the NAFLD and NASH. There are multiple potential pharmacologic strategies to rebalance aspects of disordered metabolism in NAFLD. These include therapies aimed at reducing hepatic steatosis by directly modulating lipid metabolism within the liver, inhibiting fructose metabolism, altering delivery of free fatty acids from the adipose to the liver by targeting insulin resistance and/or adipose metabolism, modulating glycemia, and altering pleiotropic metabolic pathways simultaneously. Emerging data from human genetics also supports a role for metabolic drivers in NAFLD and risk for progression to NASH. In this review, we highlight the prominent metabolic drivers of NAFLD pathogenesis and discuss the major metabolic targets of NASH pharmacotherapy.
C1 [Esler, William P.; Bence, Kendra K.] Pfizer Worldwide Res Dev & Med, Internal Med Res Unit, Cambridge, MA USA.
C3 Pfizer; Pfizer USA
RP Bence, KK (corresponding author), Pfizer Inc, 1 Portland St, Cambridge, MA 02139 USA.
EM kendrakathleen.bence@pfizer.com
OI Bence, Kendra/0000-0002-5879-4726
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NR 185
TC 107
Z9 117
U1 0
U2 14
PU ELSEVIER INC
PI SAN DIEGO
PA 525 B STREET, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 2352-345X
J9 CELL MOL GASTROENTER
JI Cell. Mol. Gastroenterol. Hepatol.
PY 2019
VL 8
IS 2
BP 247
EP 267
DI 10.1016/j.jcmgh.2019.04.007
PG 21
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA IU1IQ
UT WOS:000483330400007
PM 31004828
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Itani, O
   Kaneita, Y
AF Itani, Osamu
   Kaneita, Yoshitaka
TI The association between shift work and health: a review
SO SLEEP AND BIOLOGICAL RHYTHMS
LA English
DT Review
DE Night work; Literature review; Cancer; Metabolic; Reproduction;
   Cardiovascular
ID BREAST-CANCER; NIGHT WORK; SLEEP LOSS; CIRCADIAN DISRUPTION; PREGNANCY
   OUTCOMES; RISK; METAANALYSIS; CORTISOL; STRESS; YOUNG
AB We examined previously published systematic review studies on associations between shift work and health, using the PubMed (MEDLINE) database for our literature search. We eventually selected 30 studies: 2 studies on sleep disorders, 7 on cancer, 7 on metabolic endocrine disorders, 7 on reproduction, 4 on cardiovascular disease, 1 on gastrointestinal disorders, and 2 on the types of shift work and health-related outcomes. Meta-analyses based on quantitative combination of the data from these studies showed that shift work significantly increased the risk of the following disorders: breast cancer, diabetes mellitus, preterm delivery, abortion, low birth weight, small-for-gestational-age infants, menstrual disruption, infertility, ischemic heart disease, and ischemic stroke. Some previous studies had also reported significantly increased risks of sleep disturbance, prostate cancer, body weight change, metabolic syndrome, and fertility and gastrointestinal disorders. Some studies had gathered substantial data, including those obtained from meta-analyses, which indicated significant associations. In contrast, other studies were unable to present sufficient evidence because of the smaller number of data sets included. Therefore, based on these findings, further accumulation of epidemiological studies on this theme is warranted.
C1 [Itani, Osamu; Kaneita, Yoshitaka] Oita Univ, Fac Med, Dept Publ Hlth & Epidemiol, 1-1 Idaigaoka,Hasama Machi, Yufu City, Oita 8795593, Japan.
C3 Oita University
RP Kaneita, Y (corresponding author), Oita Univ, Fac Med, Dept Publ Hlth & Epidemiol, 1-1 Idaigaoka,Hasama Machi, Yufu City, Oita 8795593, Japan.
EM nusmpublichealth@gmail.com
RI Itani, Osamu/AEN-6732-2022
OI Itani, Osamu/0000-0002-8526-785X
FU Japanese Ministry of Health Labor and Welfare
   [H25-JUNKANKITOU-IPPAN-007]
FX This study was funded by Health Labor Sciences Research Grant
   (H25-JUNKANKITOU-IPPAN-007) from the Japanese Ministry of Health Labor
   and Welfare.
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NR 54
TC 11
Z9 14
U1 0
U2 40
PU SPRINGER JAPAN KK
PI TOKYO
PA CHIYODA FIRST BLDG EAST, 3-8-1 NISHI-KANDA, CHIYODA-KU, TOKYO, 101-0065,
   JAPAN
SN 1446-9235
EI 1479-8425
J9 SLEEP BIOL RHYTHMS
JI Sleep Biol. Rhythms
PD JUL
PY 2016
VL 14
IS 3
BP 231
EP 239
DI 10.1007/s41105-016-0055-9
PG 9
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA DY3GX
UT WOS:000384979900003
DA 2025-06-11
ER

PT J
AU Pohanka, M
AF Pohanka, Miroslav
TI Toxicology and the biological role of methanol and ethanol: Current view
SO BIOMEDICAL PAPERS-OLOMOUC
LA English
DT Review
DE ethanol; methanol; ethylene glycol; alcohol dehydrogenase; cancer;
   Alzheimer's disease; acetaldehyde dehydrogenase; gamma-aminobutyric acid
   receptor; fomepizole; alcohol; catalase; P450
ID NICOTINIC ACETYLCHOLINE-RECEPTORS; LIVER ALCOHOL-DEHYDROGENASE;
   ETHYLENE-GLYCOL; SACCHAROMYCES-CEREVISIAE; KLUYVEROMYCES-MARXIANUS;
   OXIDATIVE STRESS; ALDEHYDE DEHYDROGENASE; MESENCHYMAL TRANSITION;
   METABOLIC-ACIDOSIS; GLYCINE RECEPTORS
AB Background. Alcohol variants such as ethanol and methanol are simple organic compounds widely used in foods, pharmaceuticals, chemical synthesis, etc. Both are becoming an emerging health problem; abuse of ethanol containing beverages can lead to disparate health problems and methanol is highly toxic and unfit for consumption.
   Methods and Results. This review summarizes the basic knowledge about ethanol and methanol toxicity, the effect mechanism on the body, the current care of poisoned individuals and the implication of alcohols in the development of diseases. Alcohol related dementia, stroke, metabolic syndrome and hepatitis are discussed as well. Besides ethanol, methanol toxicity and its biodegradation pathways are addressed.
   Conclusions. The impact of ethanol and methanol on the body is shown as case reports, along with a discussion on the possible implication of alcohol in Alzheimer's disease and antidotal therapy for methanol poisoning. The role of ethanol in cancer and degenerative disorders seems to be underestimated given the current knowledge. Treatment in case of poisoning is another issue that remains unresolved even though effective protocols and drugs exist.
C1 [Pohanka, Miroslav] Univ Def, Fac Mil Hlth Sci, Hradec Kralove 1575, Czech Republic.
C3 University of Defence - Czech Republic
RP Pohanka, M (corresponding author), Univ Def, Fac Mil Hlth Sci, Hradec Kralove 1575, Czech Republic.
EM miroslav.pohanka@gmail.com
RI Pohanka, Miroslav/D-7607-2012
OI Pohanka, Miroslav/0000-0001-8804-8356
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   Yahashiri A, 2014, BIOCHEMISTRY-US, V53, P881, DOI 10.1021/bi401583f
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NR 157
TC 50
Z9 51
U1 1
U2 93
PU PALACKY UNIV, MEDICAL FAC
PI OLOMOUC
PA CENTRAL LIBRARY, HNEVOTINSKA 3, OLOMOUC, 00000, CZECH REPUBLIC
SN 1213-8118
EI 1804-7521
J9 BIOMED PAP
JI Biomed. Pap-Olomouc
PY 2016
VL 160
IS 1
BP 54
EP 63
DI 10.5507/bp.2015.023
PG 10
WC Engineering, Biomedical; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering; Research & Experimental Medicine
GA DI3HX
UT WOS:000373390800006
PM 26006090
OA gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Ben Salem, M
   Affes, H
   Ksouda, K
   Dhouibi, R
   Sahnoun, Z
   Hammami, S
   Zeghal, KM
AF Ben Salem, Maryem
   Affes, Hanen
   Ksouda, Kamilia
   Dhouibi, Raouia
   Sahnoun, Zouheir
   Hammami, Serria
   Zeghal, Khaled Mounir
TI Pharmacological Studies of Artichoke Leaf Extract and Their Health
   Benefits
SO PLANT FOODS FOR HUMAN NUTRITION
LA English
DT Review
DE Artichoke leaves extract; Cardiovascular disorders; Antioxidant;
   Hepato-protective
ID CYNARA-SCOLYMUS L.; OXIDATIVE STRESS; PROTECTIVE PROPERTIES;
   CHEMICAL-COMPOSITION; PHENOLIC-COMPOUNDS; RAT HEPATOCYTES; BY-PRODUCTS;
   IN-VITRO; RUMINANTS; CARDOON
AB Artichoke (Cynara scolymus) leaf extract was one of the few herbal remedies which the clinical and experimental trials have complemented each other. Both experimental and clinical effects have been verified through extensive biomedical herbal remedy research. Specifically, antioxidant, choleretic, hepatoprotective, bile-enhancing and lipid-lowering effects have been demonstrated, which corresponded with its historical use. Ongoing research seems to indicate that artichoke indeed have medicinal qualities. Most significant appears to be its beneficial effect on the liver. In animal studies, liquid extracts of the roots and leaves of artichoke have demonstrated an ability to protect the liver, with possibly even to help liver cells regenerate. Although research is not yet conclusive, scientists were optimistic that its long-standing use in humans for digestive and bowel problems was indeed justified. It may also play a role in lowering cholesterol and thus help to prevent heart disease. Boiled wild artichoke reduced postprandial glycemic and insulinemic responses in normal subjects but has no effect on metabolic syndrome patients. This article intended to review the wide ranging pharmacological effects of artichoke leaf extract.
C1 [Ben Salem, Maryem; Affes, Hanen; Ksouda, Kamilia; Dhouibi, Raouia; Sahnoun, Zouheir; Hammami, Serria; Zeghal, Khaled Mounir] Fac Med Sfax, Lab Pharmacol, Sfax 3029, Tunisia.
C3 Universite de Sfax
RP Affes, H (corresponding author), Fac Med Sfax, Lab Pharmacol, Ave Majida Boulila, Sfax 3029, Tunisia.
EM affeshanen13@yahoo.fr
RI salem, maryem/K-7439-2019; Dhouibi, Raouia/V-3751-2019
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NR 83
TC 125
Z9 133
U1 3
U2 90
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0921-9668
EI 1573-9104
J9 PLANT FOOD HUM NUTR
JI Plant Food Hum. Nutr.
PD DEC
PY 2015
VL 70
IS 4
BP 441
EP 453
DI 10.1007/s11130-015-0503-8
PG 13
WC Plant Sciences; Chemistry, Applied; Food Science & Technology; Nutrition
   & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Chemistry; Food Science & Technology; Nutrition &
   Dietetics
GA CX2FI
UT WOS:000365510900013
PM 26310198
DA 2025-06-11
ER

PT J
AU Macongonde, EA
   Vilela, TC
   Scaini, G
   Gonçalves, CL
   Ferreira, BK
   Costa, NLF
   de Oliveira, MR
   Avila, S
   Streck, EL
   Ferreira, GC
   Schuck, PF
AF Macongonde, Ernesto Antonio
   Vilela, Thais Cereser
   Scaini, Giselli
   Goncalves, Cinara Ludvig
   Ferreira, Bruna Klippel
   Fernandes Costa, Naithan Ludian
   de Oliveira, Marcos Roberto
   Avila Junior, Silvio
   Streck, Emilio Luiz
   Ferreira, Gustavo Costa
   Schuck, Patricia Fernanda
TI Evaluation of the In Vivo and In Vitro Effects of Fructose
   on Respiratory Chain Complexes in Tissues of Young Rats
SO DISEASE MARKERS
LA English
DT Article
ID INSULIN-RESISTANCE; OXIDATIVE STRESS; MITOCHONDRIAL DYSFUNCTION; INDUCED
   HYPERURICEMIA; METABOLIC SYNDROME; ALDOLASE-B; INTOLERANCE; DIET;
   INBORN; GENERATION
AB Hereditary fructose intolerance (HFI) is an autosomal-recessive disorder characterized by fructose and fructose-1-phosphate accumulation in tissues and biological fluids of patients. This disease results from a deficiency of aldolase B, which metabolizes fructose in the liver, kidney, and small intestine. We here investigated the effect of acute fructose administration on the activities of mitochondrial respiratory chain complexes, succinate dehydrogenase (SDH), and malate dehydrogenase (MDH) in cerebral cortex, liver, kidney, and skeletal muscle of male 30-day-old-Wistar rats. The rats received subcutaneous injection of sodium chloride (0.9%; control group) or fructose solution (5 mu mol/g; treated group). One hour later, the animals were euthanized and the cerebral cortex, liver, kidney, and skeletal muscle were isolated and homogenized for the investigations. Acute fructose administration increased complex I-III activity in liver. On the other hand, decreased complexes II and II-III activities in skeletal muscle and MDH in kidney were found. Interestingly, none of these parameters were affected in vitro. Our present data indicate that fructose administration elicits impairment of mitochondrial energy metabolism, which may contribute to the pathogenesis of the HFI patients.
C1 [Macongonde, Ernesto Antonio; Vilela, Thais Cereser; Scaini, Giselli; Goncalves, Cinara Ludvig; Ferreira, Bruna Klippel; Fernandes Costa, Naithan Ludian; Avila Junior, Silvio; Streck, Emilio Luiz; Schuck, Patricia Fernanda] Univ Extremo Catarinense, Unidade Acad Ciencias Saude, BR-88806000 Criciuma, SC, Brazil.
   [de Oliveira, Marcos Roberto] Univ Fed Mato Grosso, Dept Quim, BR-78060900 Cuiaba, MT, Brazil.
   [Ferreira, Gustavo Costa] Univ Fed Rio de Janeiro, Inst Bioquim Med Leopoldo Meis, BR-21941902 Rio De Janeiro, RJ, Brazil.
C3 Universidade Federal de Mato Grosso; Universidade Federal do Rio de
   Janeiro
RP Ferreira, GC (corresponding author), Univ Fed Rio de Janeiro, Inst Bioquim Med Leopoldo Meis, BR-21941902 Rio De Janeiro, RJ, Brazil.
EM gustavo.ferreira@bioqmed.ufrj.br; patricia.schuck@pq.cnpq.br
RI Scaini, Giselli/AAX-4436-2020; Streck, Emilio/J-7558-2013; Ferreira,
   Carlos/G-4957-2013; Goncalves, Cinara/KHC-9071-2024; de Oliveira,
   Marcos/F-1274-2013; da Costa Ferreira, Gustavo/B-6983-2014; Schuck,
   Patricia Fernanda/O-1344-2013; Scaini, Giselli/G-1378-2014
OI da Costa Ferreira, Gustavo/0000-0002-2892-8842; Schuck, Patricia
   Fernanda/0000-0003-3148-4952; Klippel Ferreira,
   Bruna/0000-0002-3329-9972; Scaini, Giselli/0000-0002-9880-0887; Vilela,
   Thais Cereser/0000-0002-2986-1715
FU UNESC; CAPES; NENASC (FAPESC/PRONEX); CNPq
FX The present work was supported by grants from UNESC, CAPES, NENASC
   (FAPESC/PRONEX), and CNPq.
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NR 47
TC 5
Z9 5
U1 0
U2 6
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 0278-0240
EI 1875-8630
J9 DIS MARKERS
JI Dis. Markers
PY 2015
VL 2015
AR 312530
DI 10.1155/2015/312530
PG 6
WC Biotechnology & Applied Microbiology; Genetics & Heredity; Medicine,
   Research & Experimental; Pathology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Genetics & Heredity; Research &
   Experimental Medicine; Pathology
GA CZ1KR
UT WOS:000366865200001
PM 26770008
OA Green Published, hybrid
DA 2025-06-11
ER

PT S
AU Masuoka, HC
   Chalasani, N
AF Masuoka, Howard C.
   Chalasani, Naga
BE Powers, AC
   Ahima, RS
TI Nonalcoholic fatty liver disease: an emerging threat to obese and
   diabetic individuals
SO YEAR IN DIABETES AND OBESITY
SE Annals of the New York Academy of Sciences
LA English
DT Article
DE steatosis; steatohepatitis; fatty liver; thiazolidinediones
ID PLACEBO-CONTROLLED TRIAL; TERM-FOLLOW-UP; RANDOMIZED CONTROLLED-TRIAL;
   TISSUE INSULIN-RESISTANCE; VITAMIN-E SUPPLEMENTATION; ALL-CAUSE
   MORTALITY; METABOLIC SYNDROME; HEPATIC STEATOSIS; RISK-FACTORS;
   OXIDATIVE STRESS
AB Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease in the Western world and its incidence is increasing rapidly. NAFLD is a spectrum ranging from simple steatosis, which is relatively benign hepatically, to nonalcoholic steatohepatitis (NASH), which can progress to cirrhosis. Obesity, insulin resistance, type 2 diabetes mellitus, and dyslipidemia are the most important risk factors for NAFLD. Due to heavy enrichment with metabolic risk factors, individuals with NAFLD are at significantly higher risk for cardiovascular disease. Individuals with NAFLD have higher incidence of type 2 diabetes. The diagnosis of NAFLD requires imaging evidence of hepatic steatosis in the absence of competing etiologies including significant alcohol consumption. Liver biopsy remains the gold standard for diagnosing NASH and for determining prognosis. Weight loss remains a cornerstone of treatment. Weight loss of similar to 5% is believed to improve steatosis, whereas similar to 10% weight loss is necessary to improve steatohepatitis. A number of pharmacologic therapies have been investigated to treat NASH, and agents such as vitamin E and thiazolidinediones have shown promise in select patient subgroups.
C1 [Masuoka, Howard C.; Chalasani, Naga] Indiana Univ Sch Med, Div Gastroenterol & Hepatol, Dept Med, Indianapolis, IN 46202 USA.
C3 Indiana University System; Indiana University Bloomington
RP Chalasani, N (corresponding author), Indiana Univ Sch Med, Div Gastroenterol & Hepatol, 1050 Wishard Blvd,RG 4100, Indianapolis, IN 46202 USA.
EM nchalasa@iupui.edu
FU NIH [K24 DK069290A]
FX This work is in part supported by NIH K24 DK069290A Grant to NC.
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NR 147
TC 215
Z9 237
U1 2
U2 24
PU BLACKWELL SCIENCE PUBL
PI OXFORD
PA OSNEY MEAD, OXFORD OX2 0EL, ENGLAND
SN 0077-8923
BN 978-1-57331-882-2
J9 ANN NY ACAD SCI
JI Ann.NY Acad.Sci.
PY 2013
VL 1281
BP 106
EP 122
DI 10.1111/nyas.12016
PG 17
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA BHL80
UT WOS:000325808500007
PM 23363012
OA Green Published, Green Accepted
DA 2025-06-11
ER

PT S
AU Plunet, WT
   Lam, CK
   Lee, JHT
   Liu, J
   Tetzlaff, W
AF Plunet, Ward T.
   Lam, Clarrie K.
   Lee, Jae H. T.
   Liu, Jie
   Tetzlaff, Wolfram
GP NYAS
TI Prophylactic dietary restriction may promote functional recovery and
   increase lifespan after spinal cord injury
SO DISCOVERIES IN SPINAL CORD INJURY RESEARCH: FROM BENCH TO BEDSIDE
SE Annals of the New York Academy of Sciences
LA English
DT Article; Proceedings Paper
CT Spinal Card Injury (SCI) Research Symposium - From the Bench to the
   Beside - The Latest Discoveries in SCI Research
CY JAN 14-16, 2008
CL New York, NY
SP New York Acad Sci
DE spinal cord injury; calorie restriction; neuroprotection; intermittent
   fasting; secondary complications; lifespan
ID CALORIE RESTRICTION; FOOD RESTRICTION; GLUCOSE-INTOLERANCE; AXONAL
   REGENERATION; CIRCULATING LEVELS; METABOLIC SYNDROME; OXIDATIVE STRESS;
   BLOOD-PRESSURE; BRAIN-DAMAGE; RISK-FACTORS
AB Functional recovery after spinal cord injury (SCI) is limited, and the injury results in a dramatic reduction in long-term lifespan. Prophylactic dietary restriction (DR) robustly extends animal lifespan, and is beneficial in models of neuronal insult. In rats, we found that one form of DR, every-other-day-fasting (EODF), which started 1 month prior to a cervical SCI improved functional recovery, resulted in greater numbers of neurons surrounding the injury site, and a similar to 45% reduction in lesion size compared to the control group. In the light of the low-risk implementation of prophylactic EODF, the clinical translation as a treatment prior to elective subacute or chronic interventions is attractive. There are numerous secondary complications after human SCI, including a 13- to 25-year reduction in lifespan. DR consistently increases median and maximal lifespan in a large range of organisms, including non-human primates. Animal research suggests that EODF might reduce many of the secondary complications people with SCI suffer from. Dietary interventions may provide the possibility to improve the quality and span of life for individuals with SCI.
C1 [Plunet, Ward T.; Lam, Clarrie K.; Lee, Jae H. T.; Liu, Jie; Tetzlaff, Wolfram] Univ British Columbia, Blusson Spinal Cord Ctr, Int Collaborat Repair Discoveries, Vancouver, BC V5Z 1M9, Canada.
C3 University of British Columbia
RP Tetzlaff, W (corresponding author), Univ British Columbia, Blusson Spinal Cord Ctr, Int Collaborat Repair Discoveries, 818 W 10th Ave, Vancouver, BC V5Z 1M9, Canada.
EM tetzlaff@icord.org
RI Lee, Jae-Hyeok/AAE-6736-2022; Tetzlaff, Wolfram/AAY-4430-2020
FU Canadian Institute for Health Research (CIHR)
FX Supported by a grant from Canadian Institute for Health Research (CIHR)
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NR 73
TC 20
Z9 24
U1 1
U2 10
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER STREET, HOBOKEN, NJ, UNITED STATES
SN 0077-8923
BN 978-1-57331-778-8
J9 ANN NY ACAD SCI
JI Ann.NY Acad.Sci.
PY 2010
VL 1198
IS S1
BP E1
EP E11
DI 10.1111/j.1749-6632.2010.05564.x
PG 11
WC Multidisciplinary Sciences; Clinical Neurology; Rehabilitation
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics; Neurosciences & Neurology;
   Rehabilitation
GA BTW55
UT WOS:000288279600001
PM 20590533
DA 2025-06-11
ER

PT J
AU Dominguez, LJ
   Veronese, N
   Barbagallo, M
AF Dominguez, Ligia J.
   Veronese, Nicola
   Barbagallo, Mario
TI Magnesium and the Hallmarks of Aging
SO NUTRIENTS
LA English
DT Review
DE magnesium; aging; hallmarks of aging; healthy aging; frailty;
   multimorbidity
ID C-REACTIVE PROTEIN; ALPHA-KETOGLUTARATE DEHYDROGENASE; CARDIOVASCULAR
   TISSUES RELEVANCE; DIETARY MAGNESIUM; OXIDATIVE STRESS; INFLAMMATORY
   RESPONSE; CELLULAR SENESCENCE; METABOLIC SYNDROME; DIABETES-MELLITUS;
   MUSCLE MASS
AB Magnesium is an essential ion in the human body that regulates numerous physiological and pathological processes. Magnesium deficiency is very common in old age. Age-related chronic diseases and the aging process itself are frequently associated with low-grade chronic inflammation, called 'inflammaging'. Because chronic magnesium insufficiency has been linked to excessive generation of inflammatory markers and free radicals, inducing a chronic inflammatory state, we formerly hypothesized that magnesium inadequacy may be considered among the intermediaries helping us explain the link between inflammaging and aging-associated diseases. We show in this review evidence of the relationship of magnesium with all the hallmarks of aging (genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, deregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, altered intercellular communication, disabled autophagy, dysbiosis, and chronic inflammation), which may positively affect the human healthspan. It is feasible to hypothesize that maintaining an optimal balance of magnesium during one's life course may turn out to be a safe and economical strategy contributing to the promotion of healthy aging. Future well-designed studies are necessary to further explore this hypothesis.
C1 [Dominguez, Ligia J.] Kore Univ Enna, Sch Med, I-94100 Enna, Italy.
   [Dominguez, Ligia J.; Veronese, Nicola; Barbagallo, Mario] Univ Palermo, Dept Med, Geriatr Unit, I-90127 Palermo, Italy.
C3 Universita Kore di ENNA; University of Palermo
RP Barbagallo, M (corresponding author), Univ Palermo, Dept Med, Geriatr Unit, I-90127 Palermo, Italy.
EM ligia.dominguez@unikore.it; nicola.veronese@unipa.it;
   mario.barbagallo@unipa.it
RI Barbara, C./AAF-3397-2020; Veronese, Nicola/K-4343-2018; BARBAGALLO,
   MARIO/K-4794-2017
OI Veronese, Nicola/0000-0002-9328-289X; BARBAGALLO,
   MARIO/0000-0002-1349-6530
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NR 254
TC 16
Z9 16
U1 9
U2 23
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD FEB
PY 2024
VL 16
IS 4
AR 496
DI 10.3390/nu16040496
PG 28
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA JH7Y6
UT WOS:001172351500001
PM 38398820
OA Green Published, gold
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Trabelsi, K
   Ammar, A
   Boujelbane, MA
   Puce, L
   Garbarino, S
   Scoditti, E
   Boukhris, O
   Khanfir, S
   Clark, CCT
   Glenn, JM
   Alhaj, OA
   Jahrami, H
   Chtourou, H
   Bragazzi, NL
AF Trabelsi, Khaled
   Ammar, Achraf
   Boujelbane, Mohamed Ali
   Puce, Luca
   Garbarino, Sergio
   Scoditti, Egeria
   Boukhris, Omar
   Khanfir, Saber
   Clark, Cain C. T.
   Glenn, Jordan M. M.
   Alhaj, Omar A. A.
   Jahrami, Haitham
   Chtourou, Hamdi
   Bragazzi, Nicola Luigi
TI Religious fasting and its impacts on individual, public, and planetary
   health: Fasting as a "religious health asset" for a healthier, more
   equitable, and sustainable society
SO FRONTIERS IN NUTRITION
LA English
DT Review
DE faith-based fasting; sustainability; nutrition; lifestyle; global
   health; public health
ID CHRONIC KIDNEY-DISEASE; RED MEAT CONSUMPTION; METABOLIC-SYNDROME;
   BODY-COMPOSITION; GUT MICROBIOME; PERIODIC VEGETARIANISM; OXIDATIVE
   STRESS; HYDRATION STATUS; RENAL-FUNCTION; UNITED-STATES
AB Religious fasting is practiced by people of all faiths, including Christianity, Islam, Buddhism, Jainism, as well as Hinduism, Judaism, and Taoism. Individual/clinical, public, global, and planetary health has traditionally been studied as separate entities. Nevertheless, religious fasting, in conjunction with other religious health assets, can provide several opportunities, ranging from the individual to the population, environmental, and planetary levels, by facilitating and supporting societal transformations and changes, such as the adoption of healthier, more equitable, and sustainable lifestyles, therein preserving the Earth's systems and addressing major interconnected, cascading, and compound challenges. In this review, we will summarize the most recent evidence on the effects of religious fasting, particularly Orthodox and Ramadan Islamic fasting, on human and public health. Further, we will explore the potential effects of religious fasting on tackling current environmental issues, with a special focus on nutrition/food restriction and planetary health. Finally, specific recommendations, particularly around dietary intake during the fasting rituals, will be provided to ensure a sustainable healthy planet.
C1 [Trabelsi, Khaled] Res Lab Educ Motr Sport & Hlth, Sfax, Tunisia.
   [Trabelsi, Khaled; Boujelbane, Mohamed Ali; Boukhris, Omar; Chtourou, Hamdi] Univ Sfax, Higher Inst Sport & Phys Educ Sfax, Sfax, Tunisia.
   [Ammar, Achraf] Johannes Gutenberg Univ Mainz, Inst Sport Sci, Dept Training & Movement Sci, Mainz, Germany.
   [Ammar, Achraf] Paris East Creteil Univ, UFR SESS STAPS, LIRTES, EA 7313, Creteil, Paris, France.
   [Puce, Luca; Garbarino, Sergio] Univ Genoa, Dept Neurosci Rehabil Ophthalmol Genet Maternal &, Genoa, Italy.
   [Scoditti, Egeria] CNR, Inst Clin Physiol, Lecce, Italy.
   [Boukhris, Omar] La Trobe Univ, Sch Allied Hlth, Human Serv & Sport, Sport & Exercise Sci, Melbourne, Vic, Australia.
   [Khanfir, Saber] Univ Tunis El Manar, Fac Med Tunis, Tunis, Tunisia.
   [Clark, Cain C. T.] Coventry Univ, Ctr Intelligent Healthcare, Coventry, England.
   [Glenn, Jordan M. M.] Univ Arkansas, Exercise Sci Res Ctr Human Performance & Recreat, Dept Hlth, Fayetteville, AR USA.
   [Alhaj, Omar A. A.] Univ Petra, Fac Pharm & Med Sci, Dept Nutr, Amman, Jordan.
   [Jahrami, Haitham] Minist Hlth, Dept Psychiat, Manama, Bahrain.
   [Jahrami, Haitham] Arabian Gulf Univ, Coll Med & Med Sci, Dept Psychiat, Manama, Bahrain.
   [Bragazzi, Nicola Luigi] York Univ, Dept Math & Stat, Lab Ind & Appl Math, Toronto, ON, Canada.
C3 Universite de Sfax; Johannes Gutenberg University of Mainz; Universite
   Paris-Est-Creteil-Val-de-Marne (UPEC); University of Genoa; Consiglio
   Nazionale delle Ricerche (CNR); Istituto di Fisiologia Clinica
   (IFC-CNR); La Trobe University; Universite de Tunis-El-Manar; Faculte de
   Medecine de Tunis (FMT); Coventry University; University of Arkansas
   System; University of Arkansas Fayetteville; Petra University; Ministry
   of Health - Bahrain; Arabian Gulf University; York University - Canada
RP Bragazzi, NL (corresponding author), York Univ, Dept Math & Stat, Lab Ind & Appl Math, Toronto, ON, Canada.
EM robertobragazzi@gmail.com
RI Boukhris, Omar/HTS-4735-2023; Scoditti, Egeria/J-8609-2016; Jahrami,
   Haitham/JVO-6632-2024; Puce, Luca/AFU-0474-2022; Chtourou,
   Hamdi/AEZ-6215-2022; Garbarino, Sergio/AAV-4629-2021; Bragazzi,
   Nicola/G-1672-2011; Clark, Cain/I-4480-2019; Achraf, Ammar/B-8455-2018;
   Khaled, Trabelsi/ABG-2717-2020
OI Achraf, Ammar/0000-0003-0347-8053; Clark, Dr. Cain/0000-0002-6610-4617;
   Khaled, Trabelsi/0000-0003-2623-9557
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NR 221
TC 20
Z9 20
U1 1
U2 28
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD NOV 24
PY 2022
VL 9
AR 1036496
DI 10.3389/fnut.2022.1036496
PG 21
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 6V2DG
UT WOS:000894864800001
PM 36505246
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Zhou, YT
   Suo, WD
   Zhang, XA
   Yang, YA
   Zhao, WZ
   Li, H
   Ni, Q
AF Zhou, Yutong
   Suo, Wendong
   Zhang, Xinai
   Yang, Yanan
   Zhao, Weizhe
   Li, Hong
   Ni, Qing
TI Targeting epigenetics in diabetic cardiomyopathy: Therapeutic potential
   of flavonoids
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Review
DE Diabetic Cardiomyopathy; Flavonoids; Epigenetics
ID ATTENUATES CARDIAC-HYPERTROPHY; DIET-INDUCED OBESITY; OXIDATIVE STRESS;
   DNA METHYLATION; DOUBLE-BLIND; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   NONCODING RNAS; RISK-FACTORS; PPAR-GAMMA
AB The pathophysiological mechanisms of diabetic cardiomyopathy have been extensively studied, but there is still a lack of effective prevention and treatment methods. The ability of flavonoids to protect the heart from diabetic cardiomyopathy has been extensively described. In recent years, epigenetics has received increasing attention from scholars in exploring the etiology and treatment of diabetes and its complications. DNA methylation, histone modifications and non-coding RNAs play key functions in the development, maintenance and progression of diabetic cardiomyopathy. Hence, prevention or reversal of the epigenetic alterations that have occurred during the development of diabetic cardiomyopathy may alleviate the personal and social burden of the disease. Flavonoids can be used as natural epigenetic modulators in alternative therapies for diabetic cardiomyopathy. In this review, we discuss the epigenetic effects of different flavonoid subtypes in diabetic cardiomyopathy and summarize the evidence from preclinical and clinical studies that already exist. However, limited research is available on the potential beneficial effects of flavonoids on the epigenetics of diabetic cardiomyopathy. In the future, clinical trials in which different flavonoids exert their antidiabetic and cardioprotective effects through various epigenetic mechanisms should be further explored.
C1 [Zhou, Yutong; Zhang, Xinai; Yang, Yanan; Ni, Qing] China Acad Chinese Med, Guangan Men Hosp, Beijing 100053, Peoples R China.
   [Suo, Wendong; Li, Hong] Shanghai Univ Tradit Chinese Med, LongHua Hosp, Shanghai 200032, Peoples R China.
   [Zhao, Weizhe] Beijing Univ Tradit Chinese Med, Coll Tradit Chinese Med, Beijing 100105, Peoples R China.
C3 Shanghai University of Traditional Chinese Medicine; Beijing University
   of Chinese Medicine
RP Ni, Q (corresponding author), China Acad Chinese Med, Guangan Men Hosp, Beijing 100053, Peoples R China.; Li, H (corresponding author), Shanghai Univ Tradit Chinese Med, LongHua Hosp, Shanghai 200032, Peoples R China.
EM tgzyyx6161@163.com; gaozhong6661@126.com
RI Zhou, Yutong/GPW-7073-2022; suo, wendong/GXH-8817-2022
FU National Natural Science Foundation of China [82174354]
FX This work was financially supported by the grant of the National Natural
   Science Foundation of China (Grant No: 82174354).
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NR 234
TC 20
Z9 20
U1 3
U2 28
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD JAN
PY 2023
VL 157
AR 114025
DI 10.1016/j.biopha.2022.114025
EA NOV 2022
PG 20
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA 7F3GB
UT WOS:000901739200008
PM 36399824
OA gold
DA 2025-06-11
ER

PT J
AU Berry, A
   Collacchi, B
   Masella, R
   Varì, R
   Cirulli, F
AF Berry, Alessandra
   Collacchi, Barbara
   Masella, Roberta
   Vari, Rosaria
   Cirulli, Francesca
TI Curcuma Longa, the "Golden Spice" to Counteract Neuroinflammaging
   and Cognitive Decline-What Have We Learned and What Needs to Be Done
SO NUTRIENTS
LA English
DT Review
DE turmeric; aging; brain; cognition; bioavailability; oxidative stress;
   inflammation
ID ALZHEIMERS ASSOCIATION WORKGROUPS; GALACTOSE-INDUCED SENESCENCE;
   DOUBLE-BLIND; LIFE-SPAN; METABOLIC SYNDROME; NATURAL-PRODUCTS; MOUSE
   MODEL; RAT MODEL; IN-VIVO; COMPARATIVE ABSORPTION
AB Due to the global increase in lifespan, the proportion of people showing cognitive impairment is expected to grow exponentially. As target-specific drugs capable of tackling dementia are lagging behind, the focus of preclinical and clinical research has recently shifted towards natural products. Curcumin, one of the best investigated botanical constituents in the biomedical literature, has been receiving increased interest due to its unique molecular structure, which targets inflammatory and antioxidant pathways. These pathways have been shown to be critical for neurodegenerative disorders such as Alzheimer's disease and more in general for cognitive decline. Despite the substantial preclinical literature on the potential biomedical effects of curcumin, its relatively low bioavailability, poor water solubility and rapid metabolism/excretion have hampered clinical trials, resulting in mixed and inconclusive findings. In this review, we highlight current knowledge on the potential effects of this natural compound on cognition. Furthermore, we focus on new strategies to overcome current limitations in its use and improve its efficacy, with attention also on gender-driven differences.
C1 [Berry, Alessandra; Collacchi, Barbara; Cirulli, Francesca] Ist Super Sanita, Ctr Behav Sci & Mental Hlth, Viale Regina Elena 299, I-00161 Rome, Italy.
   [Masella, Roberta; Vari, Rosaria] Ist Super Sanita, Ctr Gender Specif Med, Viale Regina Elena 299, I-00161 Rome, Italy.
C3 Istituto Superiore di Sanita (ISS); Istituto Superiore di Sanita (ISS)
RP Berry, A; Cirulli, F (corresponding author), Ist Super Sanita, Ctr Behav Sci & Mental Hlth, Viale Regina Elena 299, I-00161 Rome, Italy.
EM alessandra.berry@iss.it; barbara.collacchi@iss.it;
   roberta.masella@iss.it; rosaria.vari@iss.it; francesca.cirulli@iss.it
RI Cirulli, Francesca/H-5992-2019; Masella, Roberta/B-4109-2015; Berry,
   Alessandra/N-9280-2017; VARI', ROSARIA/B-4111-2015; COLLACCHI,
   BARBARA/AAC-4491-2022
OI Berry, Alessandra/0000-0001-6562-9043; Rosaria,
   Vari/0000-0003-0488-6702; Masella, Roberta/0000-0002-3173-1573; CIRULLI,
   Francesca/0000-0001-9440-1873; COLLACCHI, BARBARA/0000-0001-6330-6283
FU JPI GUTMOM project within the ERA-NET [HDHL-INTIMIC-085]; HDHL-INTIMIC
   (INtesTInal MICrobiomics) programme; HDHL-INTIMIC Knowledge Platform on
   Food, Diet, Intestinal Microbiomics and Human Health; Italian Ministry
   of Health (Ricerca Corrente)
FX This work was supported by the JPI HDHL-INTIMIC-085-GUTMOM project
   within the ERA-NET Co-fund HDHL-INTIMIC (INtesTInal MICrobiomics)
   programme and HDHL-INTIMIC Knowledge Platform on Food, Diet, Intestinal
   Microbiomics and Human Health; F.C. received funding from the Italian
   Ministry of Health (Ricerca Corrente).
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NR 160
TC 12
Z9 12
U1 1
U2 13
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD MAY
PY 2021
VL 13
IS 5
AR 1519
DI 10.3390/nu13051519
PG 18
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA ST5EF
UT WOS:000662465800001
PM 33946356
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Passos, RS
   Ribeiro, IJS
   Freire, IV
   Teles, MF
   Pires, RA
   Schettino, L
   Oliveira, AA
   Casotti, CA
   Pereira, R
AF Passos, R. S.
   Ribeiro, Icaro J. S.
   Freire, Ivna Vidal
   Teles, Mauro Fernandes
   Pires, Ramon Alves
   Schettino, Ludmila
   Oliveira, Alinne Alves
   Casotti, Cezar Augusto
   Pereira, Rafael
TI Hyperuricemia is associated with sympathovagal imbalance in older adults
SO ARCHIVES OF GERONTOLOGY AND GERIATRICS
LA English
DT Article
DE Oxidative stress; Uric acid; Aging; Sympathovagal balance
ID SERUM URIC-ACID; HEART-RATE-VARIABILITY; METABOLIC SYNDROME;
   INFLAMMATORY MARKERS; MOLECULAR PHYSIOLOGY; AUTONOMIC IMBALANCE;
   HYPERTENSION; RISK; MODULATION; ACTIVATION
AB Purpose: This study aimed to compare heart rate variability (HRV) parameters obtained through symbolic analysis (SA), between older adults with and without hyperuricemia.
   Methods: This is a cross-sectional study including 202 community-dwelling old adults, which was clinically stratified as with or without hyperuricemia, according to the cutoff point of serum uric acid >= 6 mg/dL for women and >= 7 mg/dL for men. Successive RR intervals were recorded along 5 min and analyzed with SA method. 0 V%, 1 V% and 2 V% patterns were quantified and compared between groups. Comparisons were carried out through parametric or nonparametric tests, according to the data distribution characteristics, evaluated by Kolmogorov-Smirnov test. The significance level was set as p <= 0.05 for all statistical procedures.
   Results: The prevalence of hyperuricemia was 67.8 %, and the hyperuricemic older adults exhibited significant higher values for V0% and lower values for V2% parameters when compared to normouricemic older adults.
   Conclusion: These results suggesting a sympathovagal imbalance in hyperuricemic older adults, characterized by greater sympathetic predominance (0 V%) and lower vagal modulation (2 V%) at rest conditions.
C1 [Passos, R. S.; Ribeiro, Icaro J. S.; Freire, Ivna Vidal; Teles, Mauro Fernandes; Pires, Ramon Alves; Schettino, Ludmila; Oliveira, Alinne Alves; Pereira, Rafael] Univ Estadual Sudoeste Bahia UESB, Integrat Physiol Res Ctr, Dept Biol Sci, BR-45210506 Jequie, BA, Brazil.
   [Passos, R. S.; Ribeiro, Icaro J. S.; Freire, Ivna Vidal; Teles, Mauro Fernandes; Pires, Ramon Alves; Schettino, Ludmila; Oliveira, Alinne Alves; Pereira, Rafael] Univ Estadual Sudoeste Bahia UESB, Res Grp Neuromuscular Physiol, Dept Biol Sci, BR-45210506 Jequie, BA, Brazil.
   [Passos, R. S.; Ribeiro, Icaro J. S.; Freire, Ivna Vidal; Teles, Mauro Fernandes; Pires, Ramon Alves; Schettino, Ludmila; Oliveira, Alinne Alves; Pereira, Rafael] State Univ Southwest Bahia UESB, Postgrad Program Nursing & Hlth, BR-45210506 Jequie, BA, Brazil.
   [Casotti, Cezar Augusto] State Univ Southwest Bahia UESB, Hlth Dept, BR-45210506 Jequie, BA, Brazil.
C3 Universidade Estadual do Sudoeste da Bahia; Universidade Estadual do
   Sudoeste da Bahia; Universidade Estadual do Sudoeste da Bahia;
   Universidade Estadual do Sudoeste da Bahia
RP Pereira, R (corresponding author), Univ Estadual Sudoeste Bahia UESB, Dept Ciencias Biol, R Jose Moreira Sobrinho S-no, BR-45210506 Jequie, BA, Brazil.
EM rpfisiologia@gmail.com
RI Oliveira, Alinne/AAS-8424-2021; Pereira, Rafael/L-5195-2013; Ribeiro,
   Icaro/U-8636-2017; Freire, Ivna/F-4913-2018
OI Pereira, Rafael/0000-0003-1800-1450; Ribeiro, Icaro/0000-0002-4389-7810;
   Freire, Ivna/0000-0001-6681-8727
FU Fundacao de Amparo a Pesquisa do Estado da Bahia (FAPESB) [SUS
   0055/2013]
FX Fundacao de Amparo a Pesquisa do Estado da Bahia (FAPESB) (Award Numbers
   SUS 0055/2013).
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NR 48
TC 4
Z9 4
U1 0
U2 1
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0167-4943
EI 1872-6976
J9 ARCH GERONTOL GERIAT
JI Arch. Gerontol. Geriatr.
PD SEP-OCT
PY 2020
VL 90
AR 104132
DI 10.1016/j.archger.2020.104132
PG 4
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA ND2OJ
UT WOS:000561744200042
PM 32570110
DA 2025-06-11
ER

PT J
AU Jiao, JJ
   Wei, Y
   Chen, JN
   Chen, XY
   Zhang, Y
AF Jiao, Jingjing
   Wei, Yan
   Chen, Jingnan
   Chen, Xinyu
   Zhang, Yu
TI Anti-aging and redox state regulation effects of A-type
   proanthocyanidins-rich cranberry concentrate and its comparison with
   grape seed extract in mice
SO JOURNAL OF FUNCTIONAL FOODS
LA English
DT Article
DE Cranberry concentrate; Grape seed extract; Proanthocyanidins Redox
   state; Anti-aging
ID TANDEM MASS-SPECTROMETRY; PERFORMANCE LIQUID-CHROMATOGRAPHY; OXIDATIVE
   STRESS; VACCINIUM-MACROCARPON; SUPEROXIDE-DISMUTASE;
   GLUTATHIONE-PEROXIDASE; ANTIOXIDANT CAPACITY; PROCYANIDIN EXTRACT;
   METABOLIC SYNDROME; D-GALACTOSE
AB We investigated the anti-aging and redox state regulation effects by A-type proanthocyanidins (PACs) rich cranberry concentrate (CBC) and its comparison with B-type PACs-rich grape seed extract (GSE). Using the Q-Extractive mass spectrometry, PACs dimer A and B were identified as predominant phenolic compounds of CBC and GSE, respectively, while epicatechin was present in both extracts. Using the D-galactose-induced aging mice model, effects were investigated via an 8-week oral gavage considering water-soluble vitamin E as the positive control. Both CBC and GSE reduced hepatic and brain thiobarbituric acid reactive substances, and plasma 8-isoprostane levels by 30-57%, 24-30% and 11-62%, respectively, and decreased brain and plasma monoamine oxidase activities by 27-59% and 65-71%, respectively. CBC could improve hepatic glutathione peroxidase activity by 42%, while GSE increased hepatic superoxide dismutase activity by 13%. Therefore, both extracts exerted anti-aging effects probably via regulating in vivo redox state. However, neither generated any effect on catalase activities. (C) 2016 Elsevier Ltd. All rights reserved.
C1 [Jiao, Jingjing] Zhejiang Univ, Dept Nutr, Sch Med, Hangzhou 310058, Zhejiang, Peoples R China.
   [Wei, Yan; Chen, Jingnan; Chen, Xinyu; Zhang, Yu] Zhejiang Univ, Coll Biosyst Engn & Food Sci, Dept Food Sci & Nutr, 866 Yuhangtang Rd, Hangzhou 310058, Zhejiang, Peoples R China.
   [Wei, Yan; Chen, Jingnan; Chen, Xinyu; Zhang, Yu] Zhejiang Univ, Fuli Inst Food Sci, Zhejiang R&D Ctr Food Technol & Equipment, Zhejiang Key Lab Agrofood Proc, Hangzhou 310058, Zhejiang, Peoples R China.
C3 Zhejiang University; Zhejiang University; Zhejiang University
RP Zhang, Y (corresponding author), Zhejiang Univ, Coll Biosyst Engn & Food Sci, Dept Food Sci & Nutr, 866 Yuhangtang Rd, Hangzhou 310058, Zhejiang, Peoples R China.
EM y_zhang@zju.edu.cn
RI chen, xinyu/HNR-2708-2023
FU National Natural Science Foundation of China [31401659]; Foundation for
   the Author of a Nationally Excellent Doctoral Dissertation of China
   [201260]
FX This research was financially supported by the National Natural Science
   Foundation of China (Grant No. 31401659) and by the Foundation for the
   Author of a Nationally Excellent Doctoral Dissertation of China (Grant
   No. 201260).
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NR 61
TC 31
Z9 38
U1 0
U2 84
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1756-4646
J9 J FUNCT FOODS
JI J. Funct. Food.
PD MAR
PY 2017
VL 30
BP 63
EP 73
DI 10.1016/j.jff.2016.12.039
PG 11
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA EL9FF
UT WOS:000394924700008
DA 2025-06-11
ER

PT J
AU Georgopoulou, U
   Dimitriadis, A
   Foka, P
   Karamichali, E
   Mamalaki, A
AF Georgopoulou, Urania
   Dimitriadis, Alexios
   Foka, Pelagia
   Karamichali, Eirini
   Mamalaki, Avgi
TI Hepcidin and the iron enigma in HCV infection
SO VIRULENCE
LA English
DT Review
DE lipid metabolism; hepatitis C virus; cell signaling pathways; hepcidin;
   iron
ID HEPATITIS-C-VIRUS; FATTY LIVER-DISEASE; CORE PROTEIN;
   LIPID-PEROXIDATION; OXIDATIVE STRESS; METABOLIC SYNDROME; SIGNALING
   PATHWAY; RECEPTOR-ALPHA; GROWTH-FACTOR; PEGYLATED INTERFERON
AB An estimated 30-40% of patients with chronic hepatitis C have elevated serum iron, transferrin saturation, and ferritin levels. Clinical data suggest that iron is a co-morbidity factor for disease progression following HCV infection. Iron is essential for a number of fundamental metabolic processes in cells and organisms. Mammalian iron homeostasis is tightly regulated and this is maintained through the coordinated action of sensory and regulatory networks that modulate the expression of iron-related proteins at the transcriptional and/or posttranscriptional levels. Disturbances of iron homeostasis have been implicated in infectious disease pathogenesis. Viruses, similarly to other pathogens, can escape recognition by the immune system, but they need iron from their host to grow and spread. Hepcidin is a 25-aa peptide, present in human serum and urine and represents the key peptide hormone, which modulates iron homeostasis in the body. It is synthesized predominantly by hepatocytes and its mature form is released in circulation. In this review, we discuss recent advances in the exciting crosstalk of molecular mechanisms and cell signaling pathways by which iron and hepcidin production influences HCV-induced liver disease.
C1 [Georgopoulou, Urania; Foka, Pelagia; Karamichali, Eirini] Hellenic Pasteur Inst, Mol Virol Lab, Athens, Greece.
   [Dimitriadis, Alexios; Foka, Pelagia; Mamalaki, Avgi] Hellenic Pasteur Inst, Lab Mol Biol & Immunobiotechnol, Athens, Greece.
RP Georgopoulou, U (corresponding author), Hellenic Pasteur Inst, Mol Virol Lab, Athens, Greece.
EM uraniag@pasteur.gr
RI Karamichali, Eirini/AAQ-5175-2020; Foka, Pelagia/AAQ-4267-2020;
   Georgopoulou, Urania/AAQ-3831-2020
OI Georgopoulou, Urania/0000-0002-2784-3695; Foka,
   Pelagia/0000-0002-6888-7678; Dimitriadis, Alexios/0000-0002-1826-1423;
   Karamichali, Eirini/0000-0002-9288-7854
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NR 151
TC 34
Z9 36
U1 0
U2 13
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 2150-5594
EI 2150-5608
J9 VIRULENCE
JI Virulence
PD MAY 15
PY 2014
VL 5
IS 4
BP 465
EP 476
DI 10.4161/viru.28508
PG 12
WC Immunology; Infectious Diseases; Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Infectious Diseases; Microbiology
GA AH0NR
UT WOS:000335817300007
PM 24626108
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Johnson, RJ
   Sánchez-Lozada, LG
   Lanaspa, MA
AF Johnson, Richard J.
   Sanchez-Lozada, Laura G.
   Lanaspa, Miguel A.
TI The fructose survival hypothesis as a mechanism for unifying the various
   obesity hypotheses
SO OBESITY
LA English
DT Review
ID URIC-ACID; METABOLIC SYNDROME; DIABETES-MELLITUS; LEPTIN RESISTANCE;
   DIETARY FRUCTOSE; OXIDATIVE STRESS; BODY-WEIGHT; METAANALYSIS;
   HOMEOSTASIS; INSIGHTS
AB The pathogenesis of obesity remains contested. Although genetics is important, the rapid rise in obesity with Western culture and diet suggests an environmental component. Today, some of the major hypotheses for obesity include the energy balance hypothesis, the carbohydrate-insulin model, the protein-leverage hypothesis, and the seed oil hypothesis. Each hypothesis has its own support, creating controversy over their respective roles in driving obesity. Here we propose that all hypotheses are largely correct and can be unified by another dietary hypothesis, the fructose survival hypothesis. Fructose is unique in resetting ATP levels to a lower level in the cell as a consequence of suppressing mitochondrial function, while blocking the replacement of ATP from fat. The low intracellular ATP levels result in carbohydrate-dependent hunger, impaired satiety (leptin resistance), and metabolic effects that result in the increased intake of energy-dense fats. This hypothesis emphasizes the unique role of carbohydrates in stimulating intake while fat provides the main source of energy. Thus, obesity is a disorder of energy metabolism, in which there is low usable energy (ATP) in the setting of elevated total energy. This leads to metabolic effects independent of excess energy while the excess energy drives weight gain.
C1 [Johnson, Richard J.] Rocky Mt VA Med Ctr, Div Nephrol, Aurora, CO USA.
   [Johnson, Richard J.; Lanaspa, Miguel A.] Univ Colorado, Dept Med, Anschutz Med Campus, Aurora, CO USA.
   [Sanchez-Lozada, Laura G.] Inst Nacl Cardiol Ignacio Chavez, Lab Renal Physiopathol, Mexico City, Mexico.
   [Johnson, Richard J.] Univ Colorado, Anschutz Med Campus,12700 E 19th Ave,RC-2 Res Bldg, Aurora, CO 80045 USA.
C3 University of Colorado System; University of Colorado Anschutz Medical
   Campus; National Institute of Cardiology - Mexico; University of
   Colorado System; University of Colorado Anschutz Medical Campus
RP Johnson, RJ (corresponding author), Univ Colorado, Anschutz Med Campus,12700 E 19th Ave,RC-2 Res Bldg, Aurora, CO 80045 USA.
EM richard.johnson@ucdenver.edu
RI Lanaspa, Miguel/AAO-4971-2020; Sanchez-Lozada, Laura/AAS-2104-2021
OI Johnson, Richard/0000-0003-3312-8193
FU U.S. Department of Veterans Affairs [BXI01BX004501]
FX U.S. Department of Veterans Affairs, Grant/Award Number: BXI01BX004501
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NR 76
TC 6
Z9 6
U1 1
U2 16
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1930-7381
EI 1930-739X
J9 OBESITY
JI Obesity
PD JAN
PY 2024
VL 32
IS 1
BP 12
EP 22
DI 10.1002/oby.23920
EA OCT 2023
PG 11
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA MP8J1
UT WOS:001086588600001
PM 37846155
OA Bronze
DA 2025-06-11
ER

PT J
AU Nava, V
   Licata, P
   Biondi, V
   Catone, G
   Gugliandolo, E
   Pugliese, M
   Passantino, A
   Crupi, R
   Aragona, F
AF Nava, Vincenzo
   Licata, Patrizia
   Biondi, Vito
   Catone, Giuseppe
   Gugliandolo, Enrico
   Pugliese, Michela
   Passantino, Annamaria
   Crupi, Rosalia
   Aragona, Francesca
TI Horse Whole Blood Trace Elements from Different Sicily Areas:
   Biomonitoring of Environmental Risk
SO BIOLOGICAL TRACE ELEMENT RESEARCH
LA English
DT Article
DE Whole blood; ICP-MS; Horse; Mineral elements; Sicily; Toxicological risk
ID METABOLIC SYNDROME; INSULIN-RESISTANCE; SERUM ZINC; OXIDATIVE STRESS;
   SUPPLEMENTATION; ASSOCIATION; MEN; MICRONUTRIENT; INFLAMMATION;
   COMPONENTS
AB Horses are excellent bioindicators for the assessment of environmental pollution. The aim of this study was to evaluate the levels and potential bioaccumulation of 28 mineral elements in 75 horse whole blood samples collected from five pollution-prone areas of Sicily, Italy. A direct mercury analyzer (DMA-80) was used for Hg determination, and an inductively coupled plasma mass spectrometer (ICP-MS) for all other elements. A one-way ANOVA test, followed by Bonferroni's multiple comparison for post hoc comparison, was applied to assess statistically significant differences between mineral elements and the five experimental groups. The levels of mineral elements in hay and concentrate were below the limits set by Regulation No. 744/2012. The mineral content of whole blood samples was slightly influenced by the region of origin of the horse. p values < 0.05 were statistically meaningful. However, the concentrations of mineral elements in horses' whole blood remained within reference ranges. In conclusion, the present study shows that the mineral content does not represent a toxicological risk for the analyzed horses. In addition, the study areas did not appear to show a high mineral element contamination.
C1 [Nava, Vincenzo; Licata, Patrizia; Biondi, Vito; Catone, Giuseppe; Gugliandolo, Enrico; Pugliese, Michela; Passantino, Annamaria; Crupi, Rosalia; Aragona, Francesca] Univ Messina, Dept Vet Sci, Via Giovanni Palatucci, I-98168 Messina, Italy.
C3 University of Messina
RP Nava, V (corresponding author), Univ Messina, Dept Vet Sci, Via Giovanni Palatucci, I-98168 Messina, Italy.
EM vnava@unime.it
RI Licata, Patrizia/AAM-5842-2020; pugliese, michela/L-3087-2015; Nava,
   Vincenzo/HHM-3616-2022; Gugliandolo, Enrico/AAB-9972-2019; Crupi,
   Rosalia/U-4364-2019
OI Nava, Vincenzo/0000-0001-5966-4467
FU The Ethics Review Board (Veterinary Department Ethics Committee) of the
   University of Messina considers that this type of project does not fall
   under the legislation for the protection of animals used for scientific
   purposes, national decree-law 113/2013 (
FX The Ethics Review Board (Veterinary Department Ethics Committee) of the
   University of Messina considers that this type of project does not fall
   under the legislation for the protection of animals used for scientific
   purposes, national decree-law 113/2013 (2010-63-EU directive). It
   considers there are no procedures conducted on animals. The blood used
   in this study was obtained from horses brought to a laboratory of
   analysis for routine (hemocytometric and biochemical) by a veterinarian
   according to good practices. Following clinical tests, the excess blood
   was obtained by the authors of the manuscript with the owner's
   authorization and written informed consent as a free donation from the
   owner for scientific purposes.
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NR 46
TC 5
Z9 6
U1 3
U2 12
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0163-4984
EI 1559-0720
J9 BIOL TRACE ELEM RES
JI Biol. Trace Elem. Res.
PD JUL
PY 2024
VL 202
IS 7
BP 3086
EP 3096
DI 10.1007/s12011-023-03889-5
EA OCT 2023
PG 11
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA TU9Q5
UT WOS:001081657400002
PM 37817046
DA 2025-06-11
ER

PT J
AU Balak, DMW
   Piaserico, S
   Kasujee, I
AF Balak, Deepak M. W.
   Piaserico, Stefano
   Kasujee, Ismail
TI Non-Alcoholic Fatty Liver Disease (NAFLD) in Patients with Psoriasis: A
   Review of the Hepatic Effects of Systemic Therapies
SO PSORIASIS-TARGETS AND THERAPY
LA English
DT Review
DE non-alcoholic fatty liver disease; psoriasis; fumaric acid esters;
   Nrf2-activation
ID FACTOR-ALPHA BLOCKADE; RHEUMATOID-ARTHRITIS; INSULIN-RESISTANCE; PLAQUE
   PSORIASIS; NATURAL-HISTORY; RISK; STEATOHEPATITIS; METHOTREXATE;
   ACITRETIN; INJURY
AB There is increasing interest in the association between psoriasis and non-alcoholic fatty liver disease (NAFLD), which is a prevalent liver disease characterized by excessive fat storage and inflammation that can progress to fibrosis and cancer. Patients with psoriasis have a two-fold higher risk to develop NAFLD and a higher risk to progress to more severe liver disease. Psoriasis and NAFLD share common risk factors such as smoking, alcohol consumption, and the presence of metabolic syndrome and its component disorders. In addition, both psoriasis and NAFLD hinge upon a systemic low-grade inflammation that can lead to a vicious cycle of progressive liver damage in NAFLD as well as worsening of the underlying psoriasis. Other important shared pathophysiological pathways include peripheral insulin resistance and oxidative stress. NAFLD should receive clinical awareness as important comorbidity in psoriasis. In this review, we assess the recent literature on the epidemiological and pathophysiological relationship of psoriasis and NAFLD, discuss the clinical implications of NAFLD in psoriasis patients, and summarize the hepatotoxic and hepatoprotective potential of systemic psoriasis therapies.
C1 [Balak, Deepak M. W.] LangeLand Ziekenhuis, Dept Dermatol, Zoetermeer, Netherlands.
   [Balak, Deepak M. W.] Ghent Univ Hosp, Dept Dermatol, Ghent, Belgium.
   [Piaserico, Stefano] Univ Padua, Dept Med, Dermatol Unit, Padua, Italy.
   [Kasujee, Ismail] Almirall GMA, Barcelona, Spain.
C3 Ghent University; Ghent University Hospital; University of Padua
RP Balak, DMW (corresponding author), LangeLand Ziekenhuis, Dept Dermatol, Zoetermeer, Netherlands.; Balak, DMW (corresponding author), Ghent Univ Hosp, Dept Dermatol, Ghent, Belgium.
EM balak.dmw@gmail.com
FU Almirall, Barcelona, Spain
FX This article was supported by an unrestricted educational grant from
   Almirall, Barcelona, Spain.
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NR 124
TC 26
Z9 26
U1 2
U2 6
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
EI 2230-326X
J9 PSORIASIS-TARGETS TH
JI Psoriasis-Targets Ther
PY 2021
VL 11
BP 151
EP 168
DI 10.2147/PTT.S342911
PG 18
WC Dermatology
WE Emerging Sources Citation Index (ESCI)
SC Dermatology
GA XV4KO
UT WOS:000734912900001
PM 34909410
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Misiak, B
   Krefft, M
   Bielawski, T
   Moustafa, AA
   Sasiadek, MM
   Frydecka, D
AF Misiak, Blazej
   Krefft, Maja
   Bielawski, Tomasz
   Moustafa, Ahmed A.
   Sasiadek, Maria M.
   Frydecka, Dorota
TI Toward a unified theory of childhood trauma and psychosis: A
   comprehensive review of epidemiological, clinical, neuropsychological
   and biological findings
SO NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
LA English
DT Review
DE Childhood trauma; Early-life stress; Psychosis; Schizophrenia
ID ULTRA-HIGH-RISK; CORTISOL AWAKENING RESPONSE; AUDITORY VERBAL
   HALLUCINATIONS; PITUITARY-ADRENAL AXIS; SEVERE MENTAL-ILLNESS;
   1ST-EPISODE PSYCHOSIS; DNA-METHYLATION; SOCIAL DEFEAT; NEUROTROPHIC
   FACTOR; METABOLIC SYNDROME
AB There is a growing body of research focused on the relationship between childhood trauma and the risk of developing psychosis. Numerous studies, including many large-scale population-based studies, controlling for possible mediating variables, provide persuasive evidence of a dose-response association and are indicative of a causal relationship. Existing evidence supports the specificity model, showing differential associations between particular adversities and clinical symptoms, with cumulative adversity causing less favorable clinical and functional outcomes in psychotic patients. To date, several psychological and biological models have been proposed to search for underlying developmental trajectories leading to the onset of psychosis, influencing psychopathological manifestation and negative functional outcomes due to a history of childhood trauma. In this article, we provide a unified review on the relationship between childhood trauma and psychosis by integrating results of epidemiological, clinical, neuropsychological and biological studies. The question whether psychosis with a positive history of childhood trauma should be considered as a new psychotic phenotype, requiring specific therapeutic interventions, warrants further investigation. (C) 2017 Elsevier Ltd. All rights reserved.
C1 [Misiak, Blazej; Sasiadek, Maria M.] Dept Genet, 1 Marcinkowski St, PL-50368 Wroclaw, Poland.
   [Krefft, Maja; Bielawski, Tomasz; Frydecka, Dorota] Dept Psychiat, 10 Pasteur St, PL-50367 Wroclaw, Poland.
   [Moustafa, Ahmed A.] Univ Western Sydney, Mares Inst Brain & Behav, Sch Social Sci & Psychol, Penrith, NSW, Australia.
C3 Western Sydney University
RP Misiak, B (corresponding author), Dept Genet, 1 Marcinkowski St, PL-50368 Wroclaw, Poland.
EM mblazej@interia.eu
RI Moustafa, Ahmed/AAM-2836-2021; Misiak, Błażej/ABA-2657-2021; Frydecka,
   Dorota/ABD-8176-2021
OI Sasiadek, Maria/0000-0002-7599-7074; Moustafa,
   Ahmed/0000-0001-5971-273X; Misiak, Blazej/0000-0002-5392-6398; Frydecka,
   Dorota/0000-0001-8582-9958; Bielawski, Tomasz/0000-0002-2610-2414
FU Ministry of Science and Higher Education [IP2015 052474]
FX This article was prepared in frame of the Iuventus Plus project (IP2015
   052474) funded by the Ministry of Science and Higher Education.
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NR 212
TC 139
Z9 154
U1 2
U2 52
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0149-7634
EI 1873-7528
J9 NEUROSCI BIOBEHAV R
JI Neurosci. Biobehav. Rev.
PD APR
PY 2017
VL 75
BP 393
EP 406
DI 10.1016/j.neubiorev.2017.02.015
PG 14
WC Behavioral Sciences; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Behavioral Sciences; Neurosciences & Neurology
GA ER5WY
UT WOS:000398876000026
PM 28216171
DA 2025-06-11
ER

PT J
AU Gilglioni, EH
   Campos, LB
   Oliveira, MC
   Garcia, RF
   Ambiel, CR
   Buzzo, AJD
   Ishii-Iwamoto, EL
   Salgueiro-Pagadigorria, CL
AF Gilglioni, Eduardo Hideo
   Campos, Lilian Brites
   Oliveira, Monique Cristine
   Garcia, Rosangela Fernandes
   Ambiel, Celia Regina
   dos Reis Buzzo, Ana Julia
   Ishii-Iwamoto, Emy Luzia
   Salgueiro-Pagadigorria, Clairce Luzia
TI Beneficial Effects of Tibolone on Blood Pressure and Liver Redox Status
   in Ovariectomized Rats With Renovascular Hypertension
SO JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL
   SCIENCES
LA English
DT Article
DE Hypertension; Liver lipid metabolism; Liver redox status; Estrogen
   deficiency; Tibolone
ID HORMONE REPLACEMENT THERAPY; OXIDATIVE STRESS; BODY-COMPOSITION;
   GLUCOSE-6-PHOSPHATE-DEHYDROGENASE; GLUTATHIONE; PURIFICATION;
   METABOLISM; OSTEOPENIA; PEROXIDES; STEATOSIS
AB Estrogen deficiency is associated with aging and increases the incidence of metabolic syndrome and hypertension. In this study, the effects of tibolone, a synthetic steroid, on the cardiovascular system, liver lipid metabolism, and redox status were evaluated, in ovariectomized (OVX) rats with renovascular hypertension (two-kidneys, one-clip, OVX + 2K1C). This study encompassed direct measurements of mean arterial pressure, plasma biochemical analysis, liver lipid contents, and assessments of the mitochondrial and peroxisomal beta-oxidation capacities. Additionally, the liver redox status was assayed. Tibolone significantly reduced the mean arterial pressure of OVX + 2K1C rats, albeit reducing total and high-density lipoprotein (HDL) cholesterol levels. In the liver, although exerting an undesirable inhibition of mitochondrial and peroxisomal beta-oxidation, tibolone reversed steatosis. Tibolone also improved the liver redox status: the reduced glutathione contents and the activity of glucose-6-phosphate dehydrogenase were restored by this compound, which also reduced the levels of thiobarbituric acid reactive substances and the generation of mitochondrial reactive oxygen species. So, tibolone reversed the main alterations caused by hypertension and estrogen deficiency.
C1 [Gilglioni, Eduardo Hideo; Campos, Lilian Brites; Garcia, Rosangela Fernandes; Ambiel, Celia Regina; dos Reis Buzzo, Ana Julia; Salgueiro-Pagadigorria, Clairce Luzia] Univ Maringa, Dept Physiol Sci, BR-87020900 Maringa, Parana, Brazil.
   [Oliveira, Monique Cristine; Ishii-Iwamoto, Emy Luzia; Salgueiro-Pagadigorria, Clairce Luzia] Univ Maringa, Dept Biochem, BR-87020900 Maringa, Parana, Brazil.
RP Salgueiro-Pagadigorria, CL (corresponding author), Univ Maringa, Dept Biochem, BR-87020900 Maringa, Parana, Brazil.
EM clspagadigorria@uem.br
RI Campos-Shimada, Lilian/M-8719-2013; Gilglioni, Eduardo/H-2784-2012;
   Ishii-Iwamoto, Emy/C-1323-2013; Oliveira, Monique/M-2241-2016
OI Ishii Iwamoto, Emy Luiza/0000-0001-8708-3643; Oliveira,
   Monique/0000-0002-9667-0724; Campos-Shimada, Lilian
   Brites/0000-0002-5226-6519; Gilglioni, Eduardo Hideo/0000-0001-5137-4051
FU Conselho Nacional de Pesquisa Cientifica e Tecnologica [CNPq
   475704/2010]; Coordenacao de Aperfeicoamento de Pessoal de Nivel
   Superior [CAPES 014/10]
FX Conselho Nacional de Pesquisa Cientifica e Tecnologica (CNPq
   475704/2010); Coordenacao de Aperfeicoamento de Pessoal de Nivel
   Superior (CAPES 014/10).
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TC 8
Z9 8
U1 0
U2 39
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1079-5006
EI 1758-535X
J9 J GERONTOL A-BIOL
JI J. Gerontol. Ser. A-Biol. Sci. Med. Sci.
PD MAY
PY 2013
VL 68
IS 5
BP 510
EP 520
DI 10.1093/gerona/gls210
PG 11
WC Geriatrics & Gerontology; Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA 125KO
UT WOS:000317538900002
PM 23089337
OA Bronze
DA 2025-06-11
ER

PT J
AU Cao, CJ
   Shi, MX
   Wang, XR
   Yao, Y
   Zeng, R
AF Cao, Chujin
   Shi, Mengxia
   Wang, Xiuru
   Yao, Ying
   Zeng, Rui
TI Effects of probiotics on non-alcoholic fatty liver disease: a review of
   human clinical trials
SO FRONTIERS IN NUTRITION
LA English
DT Review
DE non-alcoholic fatty liver disease; gut microbiota; gut-liver axis;
   probiotics; randomized clinical trial
ID ANTIBIOTIC-ASSOCIATED DIARRHEA; GUT MICROBIOME; OXIDATIVE STRESS; OBESE
   CHILDREN; STEATOHEPATITIS; NAFLD; INFLAMMATION; FIBROSIS; PATHOGENESIS;
   METABOLISM
AB Non-alcoholic fatty liver disease (NAFLD) is a global public health issue, of which the prevalence is about 25% worldwide. The incidence of NAFLD is increasing in patients with obesity, type 2 diabetes (T2DM) and the metabolic syndrome. The crosstalk between gut microbiota and metabolism-related diseases has been raised great concern. Patients with NAPLD were observed with disruption of gut microbiota. Several researches showed that gut microbiota was the determination in the progression of NAFLD by the experiments using fecal microbiota transplants. The application of probiotics, as one of the most important strategies for the regulation of gut microbiota disorder, have been explored whether it is beneficial to gut-related diseases of intestine-distal organs. Some probiotics were showed to improve the liver parameters and phenotype in patients with NAFLD. The oral intake of them might become the effective management for the prevention and treatment of NAFLD. In this review, we summarized the human clinical trials focusing on the effects of probiotics on NAFLD to give some evidential reference for the administration of NAFLD.
C1 [Cao, Chujin; Shi, Mengxia; Wang, Xiuru; Yao, Ying; Zeng, Rui] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Div Nephrol, Wuhan, Peoples R China.
   [Yao, Ying] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Div Nutr, Wuhan, Peoples R China.
   [Zeng, Rui] Chinese Acad Med Sci, Key Lab Organ Transplantat, Minist Educ, Wuhan, Peoples R China.
   [Zeng, Rui] Chinese Acad Med Sci, NHC Key Lab Organ Transplantat, Wuhan, Peoples R China.
C3 Huazhong University of Science & Technology; Huazhong University of
   Science & Technology; Chinese Academy of Medical Sciences - Peking Union
   Medical College; Ministry of Education - China; Chinese Academy of
   Medical Sciences - Peking Union Medical College
RP Yao, Y; Zeng, R (corresponding author), Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Div Nephrol, Wuhan, Peoples R China.; Yao, Y (corresponding author), Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Div Nutr, Wuhan, Peoples R China.; Zeng, R (corresponding author), Chinese Acad Med Sci, Key Lab Organ Transplantat, Minist Educ, Wuhan, Peoples R China.; Zeng, R (corresponding author), Chinese Acad Med Sci, NHC Key Lab Organ Transplantat, Wuhan, Peoples R China.
EM yaoyingkk@126.com
FU National Natural Science Foundation of China [81974087, 81974086,
   82170701]
FX Funding This work was supported by the National Natural Science
   Foundation of China (grant numbers 81974087, 81974086, and 82170701).
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NR 89
TC 14
Z9 14
U1 5
U2 25
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD JUN 30
PY 2023
VL 10
AR 1155306
DI 10.3389/fnut.2023.1155306
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA L7VJ7
UT WOS:001025298800001
PM 37457967
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Abudureyimu, M
   Luo, XM
   Wang, X
   Sowers, JR
   Wang, WS
   Ge, JB
   Ren, J
   Zhang, YM
AF Abudureyimu, Miyesaier
   Luo, Xuanming
   Wang, Xiang
   Sowers, James R.
   Wang, Wenshuo
   Ge, Junbo
   Ren, Jun
   Zhang, Yingmei
TI Heart failure with preserved ejection fraction (HFpEF) in type 2
   diabetes mellitus: from pathophysiology to therapeutics
SO JOURNAL OF MOLECULAR CELL BIOLOGY
LA English
DT Review
DE type 2 diabetes mellitus; heart failure with preserved ejection
   fraction; pathophysiology; therapies
ID GLYCATION END-PRODUCTS; VENTRICULAR DIASTOLIC DYSFUNCTION; CARDIAC
   HYPERTROPHIC RESPONSE; CARDIOVASCULAR OUTCOMES; ENDOTHELIAL DYSFUNCTION;
   PROGNOSTIC-SIGNIFICANCE; OXIDATIVE STRESS; OLDER PATIENTS;
   CARDIOMYOPATHY; EXERCISE
AB Type 2 diabetes mellitus (T2DM or T2D) is a devastating metabolic abnormality featured by insulin resistance, hyperglycemia, and hyperlipidemia. T2D provokes unique metabolic changes and compromises cardiovascular geometry and function. Meanwhile, T2D increases the overall risk for heart failure (HF) and acts independent of classical risk factors including coronary artery disease, hypertension, and valvular heart diseases. The incidence of HF is extremely high in patients with T2D and is manifested as HF with preserved, reduced, and midrange ejection fraction (HFpEF, HFrEF, and HFmrEF, respectively), all of which significantly worsen the prognosis for T2D. HFpEF is seen in approximately half of the HF cases and is defined as a heterogenous syndrome with discrete phenotypes, particularly in close association with metabolic syndrome. Nonetheless, management of HFpEF in T2D remains unclear, largely due to the poorly defined pathophysiology behind HFpEF. Here, in this review, we will summarize findings from multiple preclinical and clinical studies as well as recent clinical trials, mainly focusing on the pathophysiology, potential mechanisms, and therapies of HFpEF in T2D.
C1 [Abudureyimu, Miyesaier; Wang, Xiang] Fudan Univ, Shanghai Xuhui Cent Hosp, Cardiovasc Dept, Shanghai 200031, Peoples R China.
   [Luo, Xuanming] Fudan Univ, Shanghai Xuhui Cent Hosp, Dept Gen Surg, Shanghai 200031, Peoples R China.
   [Sowers, James R.] Univ Missouri Columbia, Diabet & Cardiovasc Res Ctr, Columbia, MO 65212 USA.
   [Wang, Wenshuo; Ge, Junbo; Ren, Jun; Zhang, Yingmei] Fudan Univ, Shanghai Inst Cardiovasc Dis, Zhongshan Hosp, Dept Cardiol, Shanghai 200032, Peoples R China.
   [Ren, Jun] Univ Washington, Dept Lab Med & Pathol, Seattle, WA 98195 USA.
C3 Fudan University; Fudan University; University of Missouri System;
   University of Missouri Columbia; Fudan University; University of
   Washington; University of Washington Seattle
RP Ren, J; Zhang, YM (corresponding author), Fudan Univ, Shanghai Inst Cardiovasc Dis, Zhongshan Hosp, Dept Cardiol, Shanghai 200032, Peoples R China.; Ren, J (corresponding author), Univ Washington, Dept Lab Med & Pathol, Seattle, WA 98195 USA.
EM jren_aldh2@outlook.com; zhangym197951@126.com
RI Ren, Jun/ACG-5366-2022; Han, Yan/AAP-8400-2020; Wang,
   wenshuo/AAO-1848-2020; Ge, Junbo/LJL-3729-2024
OI Ge, Junbo/0000-0002-9360-7332; Ren, Jun/0000-0002-0275-0783
FU National Natural Science Foundation of China [81770261, 82130011];
   Science and Technology Innovation Project of the Chinese Academy of
   Medical Sciences (Health and Longevity Pilot Special Project)
   [2019-RC-HL-021]
FX This work was supported by grants from the National Natural Science
   Foundation of China (81770261 and 82130011) and Science and Technology
   Innovation Project of the Chinese Academy of Medical Sciences (Health
   and Longevity Pilot Special Project 2019-RC-HL-021).
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NR 137
TC 35
Z9 37
U1 0
U2 9
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1674-2788
EI 1759-4685
J9 J MOL CELL BIOL
JI J. Mol. Cell Biol.
PD SEP 12
PY 2022
VL 14
IS 5
AR mjac028
DI 10.1093/jmcb/mjac028
EA SEP 2022
PG 12
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA 4L7AE
UT WOS:000852780700001
PM 35511596
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Bisaccia, G
   Ricci, F
   Mantini, C
   Tana, C
   Romani, GL
   Schiavone, C
   Gallina, S
AF Bisaccia, Giandomenico
   Ricci, Fabrizio
   Mantini, Cesare
   Tana, Claudio
   Romani, Gian Luca
   Schiavone, Cosima
   Gallina, Sabina
TI Nonalcoholic fatty liver disease and cardiovascular disease phenotypes
SO SAGE OPEN MEDICINE
LA English
DT Review
DE Cardiovascular; gastroenterology/hepatology; NAFLD; cardiovascular
   disease; cardiovascular risk
ID EPICARDIAL ADIPOSE-TISSUE; CORONARY-HEART-DISEASE; GROWTH-FACTOR 21;
   TERM-FOLLOW-UP; INSULIN-RESISTANCE; INCREASED RISK; ENDOTHELIAL
   DYSFUNCTION; NATURAL-HISTORY; PLASMA-LEVELS; RATE RECOVERY
AB Nonalcoholic fatty liver disease is increasingly recognized as a major global health problem. Intertwined with diabetes, metabolic syndrome, and obesity, nonalcoholic fatty liver disease embraces a spectrum of liver conditions spanning from steatosis to inflammation, fibrosis, and liver failure. Compared with the general population, the prevalence of cardiovascular disease is higher among nonalcoholic fatty liver disease patients, in whom comprehensive cardiovascular risk assessment is highly desirable. Preclinical effects of nonalcoholic fatty liver disease on the heart include both metabolic and structural changes eventually preceding overt myocardial dysfunction. Particularly, nonalcoholic fatty liver disease is associated with enhanced atherosclerosis, heart muscle disease, valvular heart disease, and arrhythmias, with endothelial dysfunction, inflammation, metabolic dysregulation, and oxidative stress playing in the background. In this topical review, we aimed to summarize current evidence on the epidemiology of nonalcoholic fatty liver disease, discuss the pathophysiological links between nonalcoholic fatty liver disease and cardiovascular disease, illustrate nonalcoholic fatty liver disease-related cardiovascular phenotypes, and finally provide a glimpse on the relationship between nonalcoholic fatty liver disease and cardiac steatosis, mitochondrial (dys)function, and cardiovascular autonomic dysfunction.
C1 [Bisaccia, Giandomenico; Ricci, Fabrizio; Mantini, Cesare; Romani, Gian Luca; Gallina, Sabina] G dAnnunzio Univ Chieti & Pescara, Inst Adv Biomed Technol, Dept Neurosci Imaging & Clin Sci, Via Luigi Polacchi 11, I-66100 Chieti, Italy.
   [Ricci, Fabrizio] Lund Univ, Dept Clin Sci, Malmo, Sweden.
   [Tana, Claudio] Univ Hosp Parma, Internal Med & Crit Subacute Care Unit, Med Geriatr Rehabil Dept, Parma, Italy.
   [Tana, Claudio] Univ Hosp Parma, Dept Med & Surg, Parma, Italy.
   [Schiavone, Cosima] G dAnnunzio Univ Chieti & Pescara, Dept Internist Ultrasound, Chieti, Italy.
C3 G d'Annunzio University of Chieti-Pescara; Lund University; University
   of Parma; University Hospital of Parma; University of Parma; University
   Hospital of Parma; G d'Annunzio University of Chieti-Pescara
RP Ricci, F (corresponding author), G dAnnunzio Univ Chieti & Pescara, Inst Adv Biomed Technol, Dept Neurosci Imaging & Clin Sci, Via Luigi Polacchi 11, I-66100 Chieti, Italy.
EM fabrizio.ricci@unich.it
RI Bisaccia, Giandomenico/AAS-6124-2021; Ricci, Fabrizio/AAM-2464-2021;
   Mantini, Cesare/AAV-4125-2020; Tana, Claudio/AFU-7973-2022; Ricci,
   Fabrizio/L-5529-2017
OI Bisaccia, Giandomenico/0000-0003-4606-3093; Ricci,
   Fabrizio/0000-0002-1401-6623
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NR 195
TC 12
Z9 13
U1 3
U2 23
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 2050-3121
J9 SAGE OPEN MED
JI SAGE Open Med.
PD JUN
PY 2020
VL 8
DI 10.1177/2050312120933804
PG 15
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA ME5WC
UT WOS:000544724900001
PM 32612827
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Kim, YA
   Park, JB
   Woo, MS
   Lee, SY
   Kim, HY
   Yoo, YH
AF Kim, Yeon A.
   Park, Joon Beom
   Woo, Min Seok
   Lee, Sang Yeob
   Kim, Hye Young
   Yoo, Young Hyun
TI Persistent Organic Pollutant-Mediated Insulin Resistance
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Review
DE insulin resistance; persistent organic pollutants
ID NECROSIS-FACTOR-ALPHA; ENDOCRINE-DISRUPTING CHEMICALS;
   ENDOPLASMIC-RETICULUM STRESS; ADIPOSE-TISSUE CONCENTRATIONS; LIPID
   DROPLET ENLARGEMENT; NESTED CASE-CONTROL; PROTEIN-KINASE-B;
   POLYCHLORINATED-BIPHENYLS; MICE LACKING; DIABETES-MELLITUS
AB Persistent organic pollutants (POPs) such as organochlorine (OC) pesticides, polychlorinated biphenyls (PCBs), polychlorinated dibenzo-p-dioxins (PCDDs), and polychlorinated dibenzofurans (PCDFs) have become wide-spread environmental contaminants as a consequence of their extensive use, long-range transport, and persistence. Because POPs are highly resistant to metabolic degradation, humans bioaccumulate these lipophilic and hydrophobic pollutants in fatty tissues for many years. Previous studies have demonstrated that POPs including PCBs are involved in the development of diabetes mellitus (DM) type 2 and insulin resistance. Numerous epidemiological studies suggest an association between POP burden and DM type 2/metabolic syndrome. In addition, several experimental studies have provided additional evidence supporting the association between POP exposure and DM type 2 or insulin resistance. Epidemiological and experimental studies have provided compelling evidence indicating that exposure to POPs increases the risk of developing insulin resistance and metabolic disorders. However, the detailed molecular mechanism underlying POP-induced insulin resistance is yet to be elucidated. In this article, we review literature that has reported on the association between POP burden and insulin resistance and the mechanism underlying POP-induced insulin resistance, and discuss implications for public health.
C1 [Kim, Yeon A.; Park, Joon Beom; Lee, Sang Yeob; Kim, Hye Young; Yoo, Young Hyun] Dong A Univ, Coll Med, Dept Anat & Cell Biol, Busan 49201, South Korea.
   [Kim, Yeon A.; Park, Joon Beom; Lee, Sang Yeob; Kim, Hye Young; Yoo, Young Hyun] Dong A Univ, Coll Med, Mitochondria Hub Regulat Ctr, Busan 49201, South Korea.
   [Kim, Yeon A.] Gyeongsang Natl Univ, Changwon Hosp, Dept Anesthesiol & Pain Med, Chang Won 51472, South Korea.
   [Kim, Yeon A.] Gyeongsang Natl Univ, Inst Hlth Sci, Sch Med, Jinju 52727, South Korea.
   [Woo, Min Seok] Gyeongsang Natl Univ, Dept Convergence Med Sci, Jinju 52727, South Korea.
   [Lee, Sang Yeob] Dong A Univ, Coll Med, Dept Rheumatol, Busan 49201, South Korea.
C3 Dong A University; Dong A University; Gyeongsang National University;
   Gyeongsang National University; Gyeongsang National University; Dong A
   University
RP Yoo, YH (corresponding author), Dong A Univ, Coll Med, Dept Anat & Cell Biol, Busan 49201, South Korea.; Yoo, YH (corresponding author), Dong A Univ, Coll Med, Mitochondria Hub Regulat Ctr, Busan 49201, South Korea.
EM keivin@naver.com; csplen1990@dau.ac.kr; whitewms@naver.com;
   leesy@dau.ac.kr; dolph02@dau.ac.kr; yhyoo@dau.ac.kr
OI Kim, Yeon A/0000-0003-3364-4307; Kim, Hye Young/0000-0002-8487-3655;
   Yoo, Young/0000-0002-6809-6737
FU National Research Foundation of Korea (NRF) - Korean Government (MIST)
   [2015R1A2A1A10051603, 2016R1A5A2007009, 2016R1C1B2011721]
FX This study was supported by the National Research Foundation of Korea
   (NRF) grant funded by the Korean Government (MIST) (No.
   2015R1A2A1A10051603, 2016R1A5A2007009, and 2016R1C1B2011721).
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NR 111
TC 30
Z9 33
U1 2
U2 64
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD FEB 1
PY 2019
VL 16
IS 3
AR 448
DI 10.3390/ijerph16030448
PG 14
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA HM0CQ
UT WOS:000459113600154
PM 30717446
OA gold, Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Yamamoto, K
   Takeshita, K
   Saito, H
AF Yamamoto, Koji
   Takeshita, Kyosuke
   Saito, Hidehiko
TI Plasminogen Activator Inhibitor-1 in Aging
SO SEMINARS IN THROMBOSIS AND HEMOSTASIS
LA English
DT Article
DE PAI-1; thrombosis; fibrosis; vascular sclerosis; metabolic syndrome
ID NECROSIS-FACTOR-ALPHA; RENIN-ANGIOTENSIN SYSTEM; PAI-1 GENE-EXPRESSION;
   SMOOTH-MUSCLE-CELLS; GROWTH-FACTOR-BETA; MYOCARDIAL-INFARCTION;
   INSULIN-RESISTANCE; IN-VIVO; ENDOTHELIAL-CELLS; ADIPOSE-TISSUE
AB Plasminogen activator inhibitor-1 (PAI-1), a principal inhibitor of fibrinolysis, is induced in thrombotic, fibrotic, and cardiovascular diseases, which in turn primarily afflict the older population. This induction of PAI-1 may play an important role in the pathology of these diseases as PAI-1 can regulate the dissolution of fibrin and also inhibit the degradation of the extracellular matrix by reducing plasmin generation. PAI-1 expression is elevated in aged individuals and is significantly upregulated in a variety of pathologies associated with the process of aging, including myocardial and cerebral infarction, vascular (athero) sclerosis, cardiac and lung fibrosis, metabolic syndromes (e.g., hypertension, hyperlipidemia, and insulin resistance), cancer, and inflammatory/stress responses. Thus, PAI-1 may play a critical role in the development of aging-associated pathological changes. In addition, PAI-1 is recognized as a marker of senescence and a key member of a group of proteins collectively known as the senescence-messaging secretome. In this review, we highlight the role of PAI-1 in the pathophysiology of aging and aging-associated disorders.
C1 [Yamamoto, Koji] Nagoya Univ Hosp, Dept Transfus Med, Nagoya, Aichi 4668550, Japan.
   [Takeshita, Kyosuke] Nagoya Univ Hosp, Dept Lab Med, Nagoya, Aichi 4668550, Japan.
   [Saito, Hidehiko] Nagoya Med Ctr, Nagoya, Aichi, Japan.
C3 Nagoya University; Nagoya University; Nagoya Medical Center
RP Yamamoto, K (corresponding author), Nagoya Univ Hosp, Dept Transfus Med, Showa Ku, 65 Tsurumai, Nagoya, Aichi 4668550, Japan.
EM kojiy@med.nagoya-u.ac.jp
RI Takeshita, Kyosuke/AAD-9515-2020; Takeshita, Kyosuke/B-7008-2012
OI Takeshita, Kyosuke/0000-0002-8283-3799
FU Ministry of Education, Science, Sports and Culture; Ministry of Health
   and Welfare, Japan
FX This work was supported by grants-in-aid from the Ministry of Education,
   Science, Sports and Culture, from the Ministry of Health and Welfare,
   Japan.
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NR 100
TC 57
Z9 58
U1 2
U2 6
PU THIEME MEDICAL PUBL INC
PI NEW YORK
PA 333 SEVENTH AVE, NEW YORK, NY 10001 USA
SN 0094-6176
EI 1098-9064
J9 SEMIN THROMB HEMOST
JI Semin. Thromb. Hemost.
PD SEP
PY 2014
VL 40
IS 6
BP 652
EP 659
DI 10.1055/s-0034-1384635
PG 8
WC Hematology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Hematology; Cardiovascular System & Cardiology
GA AQ5FT
UT WOS:000342832800006
PM 25122500
DA 2025-06-11
ER

PT J
AU Pandalai, SP
   Schulte, PA
   Miller, DB
AF Pandalai, Sudha P.
   Schulte, Paul A.
   Miller, Diane B.
TI Conceptual heuristic models of the interrelationships between obesity
   and the occupational environment
SO SCANDINAVIAN JOURNAL OF WORK ENVIRONMENT & HEALTH
LA English
DT Article
DE cardiovascular disease; diet; endocrine disruptor; intervention study;
   metabolism; musculoskeletal disease; occupational health; physical
   activity; risk assessment
ID BODY-MASS INDEX; PERSISTENT ORGANIC POLLUTANTS; WORK-RELATED FACTORS;
   RISK-FACTORS; PHYSICAL-ACTIVITY; METABOLIC SYNDROME; SHIFT WORK;
   CARDIOVASCULAR-DISEASE; ENDOCRINE DISRUPTORS; BLOOD-PRESSURE
AB Objective Research and interventions targeting the relationship between work, its attendant occupational hazards, and obesity are evolving but merit further consideration in the public health arena. In this discussion paper, conceptual heuristic models are described examining the role of obesity as both a risk factor and health outcome in the occupational setting.
   Methods PubMed was searched using specific criteria from 2000 and onwards for evidence to support conceptual models in which obesity serves as a risk factor for occupational disease or an outcome of occupational exposures. Nine models are presented: four where obesity is a risk factor and five where it is an adverse effect.
   Results A broad range of work-related health effects are associated with obesity including musculoskeletal disorders, asthma, liver disease, and cardiovascular disease, among others. Obesity can be associated with occupational hazards such as shift work, sedentary work, job stress, and exposure to some chemicals.
   Conclusion Identification of combinations of risk factors pertinent to obesity in the occupational environment will provide important guidance for research and prevention.
C1 [Pandalai, Sudha P.; Schulte, Paul A.; Miller, Diane B.] NIOSH, Ctr Dis Control & Prevent, Cincinnati, OH 45226 USA.
C3 Centers for Disease Control & Prevention - USA; National Institute for
   Occupational Safety & Health (NIOSH)
RP Pandalai, SP (corresponding author), NIOSH, Ctr Dis Control & Prevent, 4676 Columbia Pkwy,MS C-15, Cincinnati, OH 45226 USA.
EM SPandalai@cdc.gov
FU Intramural CDC HHS [CC999999] Funding Source: Medline
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NR 138
TC 30
Z9 37
U1 0
U2 24
PU SCANDINAVIAN JOURNAL WORK ENVIRONMENT & HEALTH
PI HELSINKI
PA TOPELIUKSENKATU 41A, SF-00250 HELSINKI, FINLAND
SN 0355-3140
EI 1795-990X
J9 SCAND J WORK ENV HEA
JI Scand. J. Work Environ. Health
PD MAY
PY 2013
VL 39
IS 3
BP 221
EP 232
DI 10.5271/sjweh.3363
PG 12
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA AD0HW
UT WOS:000332916100002
PM 23588858
OA Green Accepted, hybrid
DA 2025-06-11
ER

PT J
AU Rabadán-Diehl, C
   Nathanielsz, P
AF Rabadan-Diehl, C.
   Nathanielsz, P.
TI From Mice to Men: research models of developmental programming
SO JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE
LA English
DT Review
DE models; opportunities; programming
ID LOW-PROTEIN-DIET; WEIGHT-GAIN; INTRAUTERINE GROWTH; BIRTH-WEIGHT;
   DIABETES-MELLITUS; FETAL-GROWTH; INSULIN-RESISTANCE; ENDOCRINE PANCREAS;
   METABOLIC SYNDROME; OXIDATIVE STRESS
AB Developmental programming can be defined as a response to a specific challenge to the mammalian organism during a critical developmental time window that alters the trajectory of development with persistent effects on offspring phenotype and predisposition to future illness. We focus on the need for studies in relevant, well-characterized animal models in the context of recent research discoveries on the challenges, mechanisms and outcomes of developmental programming. We discuss commonalities and differences in general principles of developmental programming as they apply to several species, including humans. The consequences of these differences are discussed. Obesity, metabolic disorders and cardiovascular diseases are associated with the highest percentage of morbidity and mortality worldwide. Although many of the causes are associated with lifestyle, high-energy diets and lack of physical activity, recent evidence has linked developmental programming to the epidemic of metabolic diseases. A better understanding of comparative systems physiology of mother, fetus and neonate using information provided by rapid advances in molecular biology has the potential to improve the lifetime health of future generations by providing better women's health, diagnostic tools and preventative and therapeutic interventions in individuals exposed during their development to programming influences.
C1 [Rabadan-Diehl, C.] NHLBI, Off Global Hlth, NIH, Bethesda, MD 20982 USA.
   [Nathanielsz, P.] Univ Texas Hlth Sci Ctr San Antonio, Dept Obstet & Gynecol, Ctr Pregnancy & Newborn Res, San Antonio, TX 78229 USA.
C3 National Institutes of Health (NIH) - USA; NIH National Heart Lung &
   Blood Institute (NHLBI); University of Texas System; University of Texas
   Health Science Center at San Antonio
RP Rabadán-Diehl, C (corresponding author), NHLBI, Off Global Hlth, NIH, 31 Ctr Dr,Suite 5A06C, Bethesda, MD 20982 USA.
EM rabadanc@mail.nih.gov
OI Nathanielsz, Peter/0000-0001-8410-6280
FU Intramural NIH HHS [Z99 HL999999] Funding Source: Medline
CR [Anonymous], PROM CARD HLTH DEV W
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NR 56
TC 44
Z9 51
U1 0
U2 39
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 2040-1744
EI 2040-1752
J9 J DEV ORIG HLTH DIS
JI J. Dev. Orig. Health Dis.
PD FEB
PY 2013
VL 4
IS 1
BP 3
EP 9
DI 10.1017/S2040174412000487
PG 7
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA 063KZ
UT WOS:000312998700001
PM 23525085
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Glintborg, D
   Andersen, M
AF Glintborg, Dorte
   Andersen, Marianne
TI An update on the pathogenesis, inflammation, and metabolism in hirsutism
   and polycystic ovary syndrome
SO GYNECOLOGICAL ENDOCRINOLOGY
LA English
DT Article
DE Polycystic ovary syndrome; hirsutism; androgens; insulin resistance;
   pituitary gland
ID BONE-MINERAL DENSITY; IMPAIRED GLUCOSE-TOLERANCE; INSULIN-RESISTANCE;
   PIOGLITAZONE TREATMENT; ANDROGEN EXCESS; WEIGHT-LOSS;
   DEHYDROEPIANDROSTERONE-SULFATE; SERINE PHOSPHORYLATION;
   LUTEINIZING-HORMONE; CORTISOL METABOLISM
AB Hirsutism is a common endocrine disorder, defined as increased growth of terminal hairs in a male pattern. Hirsutism is most often caused by polycystic ovary syndrome (PCOS), whereas only 5% patients are diagnosed with rare endocrine diseases. PCOS may be considered a multiorgan disease causing not only increased adrenal and ovarian sex hormone secretion but also changed secretion of gonadotrophins, growth hormone, and adrenocorticotrophic hormone (ACTH) from the pituitary. The majority of patients with PCOS are insulin resistant and PCOS is characterized by an increased inflammatory state with abdominal obesity and increased secretion of interleukins, chemokines, and adipokines. PCOS is therefore associated with an increased risk of the metabolic syndrome and type 2 diabetes (T2D). Patients with hirsutism present with increased bone mineral density despite decreased D-vitamin levels. The etiology to hirsutism and PCOS is most likely multifactorial including both genetic and environmental factors such as increased fetal stress and intrauterine growth retardation. In the present review, we give a comprehensive overview of the pathophysiology and multiple endocrine disturbances of hirsutism and PCOS.</.
C1 [Glintborg, Dorte; Andersen, Marianne] Odense Univ Hosp, Dept Endocrinol, DK-5000 Odense, Denmark.
C3 University of Southern Denmark; Odense University Hospital
RP Glintborg, D (corresponding author), Odense Univ Hosp, Dept Endocrinol, Klovervaenger 6,3rd Floor, DK-5000 Odense, Denmark.
EM dorte.glintborg@dadlnet.dk
RI Andersen, Marianne/AAE-1751-2019; Glintborg, Dorte/AAE-3676-2019
OI Glintborg, Dorte/0000-0002-8338-8025; Andersen,
   Marianne/0000-0002-4603-9504
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NR 78
TC 119
Z9 128
U1 1
U2 26
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0951-3590
EI 1473-0766
J9 GYNECOL ENDOCRINOL
JI Gynecol. Endocrinol.
PD APR
PY 2010
VL 26
IS 4
BP 281
EP 296
DI 10.3109/09513590903247873
PG 16
WC Endocrinology & Metabolism; Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Obstetrics & Gynecology
GA 567TV
UT WOS:000275470400010
PM 20141388
DA 2025-06-11
ER

PT J
AU Vekic, J
   Vujcic, S
   Bufan, B
   Bojanin, D
   Al-Hashmi, K
   Al-Rasadi, K
   Stoian, AP
   Zeljkovic, A
   Rizzo, M
AF Vekic, Jelena
   Vujcic, Sanja
   Bufan, Biljana
   Bojanin, Dragana
   Al-Hashmi, Khamis
   Al-Rasadi, Khaild
   Stoian, Anca Pantea
   Zeljkovic, Aleksandra
   Rizzo, Manfredi
TI The Role of Advanced Glycation End Products on Dyslipidemia
SO METABOLITES
LA English
DT Review
DE AGEs; glycated LDL; atherogenic dyslipidemia; small; dense LDL; diabetes
ID LOW-DENSITY-LIPOPROTEIN; MODIFIED LDL ANTIBODIES; IMMUNE-COMPLEXES; SKIN
   AUTOFLUORESCENCE; APOLIPOPROTEIN-B; SERUM; AGES; CHOLESTEROL;
   ASSOCIATION; CELLS
AB Disorders of lipoprotein metabolism and glucose homeostasis are common consequences of insulin resistance and usually co-segregate in patients with metabolic syndrome and type 2 diabetes mellitus (DM). Insulin-resistant subjects are characterized by atherogenic dyslipidemia, a specific lipid pattern which includes hypertriglyceridemia, reduced high-density lipoprotein cholesterol level, and increased proportion of small, dense low-density lipoprotein (LDL). Chronic hyperglycemia favors the processes of non-enzymatic glycation, leading to the increased production of advanced glycation end products (AGEs). Apart from direct harmful effects, AGEs are also potent inducers of oxidative stress and inflammation. In addition, increased AGEs' production may induce further qualitative modifications of small, dense LDL particles, converting them to glycated LDLs. These particles are even more atherogenic and may confer an increased cardiovascular risk. In this narrative review, we summarize the available evidence of the pathophysiological role and clinical importance of circulating AGEs and glycated LDLs in patients with dyslipidemia, particularly those with DM and related complications. In addition, we discuss recent advances and the issues that should be improved regarding laboratory assessment of AGEs and glycated LDLs, as well as the possibilities for their therapeutic modulation.
C1 [Vekic, Jelena; Vujcic, Sanja; Zeljkovic, Aleksandra] Univ Belgrade, Fac Pharm, Dept Med Biochem, Belgrade 11000, Serbia.
   [Bufan, Biljana] Univ Belgrade, Fac Pharm, Dept Microbiol & Immunol, Belgrade 11000, Serbia.
   [Bojanin, Dragana] Mother & Child Hlth Care Inst Serbia Dr Vukan Cup, Dept Clin Chem & Hematol, Belgrade 11000, Serbia.
   [Al-Hashmi, Khamis; Al-Rasadi, Khaild] Sultan Qaboos Univ, Coll Med & Hlth Sci, POB 373, Muscat, Oman.
   [Stoian, Anca Pantea] Carol Davila Univ Med, Dept Diabet, Nutr, Metab Dis, Bucharest 050474, Romania.
   [Stoian, Anca Pantea] N C Paulescu Natl Inst Diabet Nutr & Metab Dis, Bucharest 050474, Romania.
   [Rizzo, Manfredi] Univ Palermo, Dept Hlth Promot Mother & Child Care, Internal Med & Med Specialties, I-90100 Palermo, Italy.
C3 University of Belgrade; University of Belgrade; Sultan Qaboos
   University; Carol Davila University of Medicine & Pharmacy; University
   of Palermo
RP Vekic, J (corresponding author), Univ Belgrade, Fac Pharm, Dept Med Biochem, Belgrade 11000, Serbia.
EM jelena.vekic@pharmacy.bg.ac.rs
RI Al-Rasadi, Khalid/ABB-7852-2020; RIZZO, MANFREDI/GZL-0551-2022;
   Al-Rasadi, Khalid/J-7194-2015; Pantea Stoian, Anca/H-5799-2017
OI Bufan, Biljana/0000-0003-1861-5700; Zeljkovic,
   Aleksandra/0000-0001-6417-8404; Vujcic, Sanja/0000-0002-5557-1850; Al
   Hashmi, Khamis/0000-0001-5109-0729; RIZZO, Manfredi/0000-0002-9549-8504;
   Vekic, Jelena/0000-0001-7445-0504; Al-Rasadi,
   Khalid/0000-0003-0460-1236; Pantea Stoian, Anca/0000-0003-0555-526X
FU Ministry of Education, Science and Technological Development, Republic
   of Serbia (University of Belgrade, Faculty of Pharmacy)
   [451-03-68/2022-14/200161]
FX The authors from University of Belgrade, Faculty of Pharmacy, appreciate
   support from Ministry of Education, Science and Technological
   Development, Republic of Serbia(Grant Agreement with University of
   Belgrade, Faculty of Pharmacy, No. 451-03-68/2022-14/200161).
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NR 100
TC 17
Z9 18
U1 3
U2 13
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2218-1989
J9 METABOLITES
JI Metabolites
PD JAN
PY 2023
VL 13
IS 1
AR 77
DI 10.3390/metabo13010077
PG 14
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 8R0XU
UT WOS:000927623200001
PM 36677002
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Ichii, S
   Matsuoka, I
   Okazaki, F
   Shimada, Y
AF Ichii, Shogo
   Matsuoka, Izumi
   Okazaki, Fumiyoshi
   Shimada, Yasuhito
TI Zebrafish Models for Skeletal Muscle Senescence: Lessons from Cell
   Cultures and Rodent Models
SO MOLECULES
LA English
DT Review
DE sarcopenia; drug screening; animal models; skeletal muscle enlargement
ID MYOGENIC REGULATORY FACTORS; DISUSE-INDUCED MUSCLE; INDUCED AGING RATS;
   OXIDATIVE STRESS; ATROPHY; SARCOPENIA; MICE; DEXAMETHASONE; PROTEIN;
   GROWTH
AB Human life expectancy has markedly increased over the past hundred years. Consequently, the percentage of elderly people is increasing. Aging and sarcopenic changes in skeletal muscles not only reduce locomotor activities in elderly people but also increase the chance of trauma, such as bone fractures, and the incidence of other diseases, such as metabolic syndrome, due to reduced physical activity. Exercise therapy is currently the only treatment and prevention approach for skeletal muscle aging. In this review, we aimed to summarize the strategies for modeling skeletal muscle senescence in cell cultures and rodents and provide future perspectives based on zebrafish models. In cell cultures, in addition to myoblast proliferation and myotube differentiation, senescence induction into differentiated myotubes is also promising. In rodents, several models have been reported that reflect the skeletal muscle aging phenotype or parts of it, including the accelerated aging models. Although there are fewer models of skeletal muscle aging in zebrafish than in mice, various models have been reported in recent years with the development of CRISPR/Cas9 technology, and further advancements in the field using zebrafish models are expected in the future.
C1 [Ichii, Shogo; Okazaki, Fumiyoshi] Mie Univ, Grad Sch Bioresources, Tsu, Mie 5148507, Japan.
   [Matsuoka, Izumi] Mie Univ, Grad Sch Reg Innovat Studies, Tsu, Mie 5148507, Japan.
   [Okazaki, Fumiyoshi; Shimada, Yasuhito] Mie Univ, Zebrafish Drug Screening Ctr, Tsu, Mie 5148507, Japan.
   [Shimada, Yasuhito] Mie Univ, Adv Sci Res Promot Ctr, Dept Bioinformat, Tsu, Mie 5148507, Japan.
   [Shimada, Yasuhito] Mie Univ, Dept Integrat Pharmacol, Grad Sch Med, Tsu, Mie 5148507, Japan.
C3 Mie University; Mie University; Mie University; Mie University; Mie
   University
RP Shimada, Y (corresponding author), Mie Univ, Zebrafish Drug Screening Ctr, Tsu, Mie 5148507, Japan.; Shimada, Y (corresponding author), Mie Univ, Adv Sci Res Promot Ctr, Dept Bioinformat, Tsu, Mie 5148507, Japan.; Shimada, Y (corresponding author), Mie Univ, Dept Integrat Pharmacol, Grad Sch Med, Tsu, Mie 5148507, Japan.
EM shimada.yasuhito@mie-u.ac.jp
RI Shimada, Yasuhito/H-2916-2019
OI Shimada, Yasuhito/0000-0002-4111-8262; OKAZAKI,
   Fumiyoshi/0000-0002-9639-0626
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NR 140
TC 8
Z9 9
U1 3
U2 23
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1420-3049
J9 MOLECULES
JI Molecules
PD DEC
PY 2022
VL 27
IS 23
AR 8625
DI 10.3390/molecules27238625
PG 15
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 6X1GY
UT WOS:000896171500001
PM 36500717
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU He, YN
   Huang, MN
   Li, Z
   Cheng, Q
   Liu, YJ
   Xue, XX
   Xu, YL
   Zheng, YC
   Li, L
   Gao, S
   Yu, CN
AF He, Yuanyuan
   Huang, Mengnan
   Li, Zhu
   Cheng, Qi
   Liu, Yijia
   Xue, Xiaoxue
   Xu, Yilan
   Zheng, Yanchao
   Li, Lin
   Gao, Shan
   Yu, Chunquan
TI Association of Serum γ-Glutamyltransferase With C-Reactive Protein
   Levels in Patients With Coronary Heart Disease
SO ANGIOLOGY
LA English
DT Article
DE coronary heart disease; gamma-glutamyltransferase; C-reactive protein
ID ALL-CAUSE MORTALITY; METABOLIC SYNDROME; OXIDATIVE STRESS;
   GLUTAMYLTRANSFERASE; INFLAMMATION; RISK
AB Serum gamma-glutamyltransferase (GGT) levels have been shown to be associated with C-reactive protein (CRP) levels. Nevertheless, studies on this relationship in coronary heart disease (CHD) populations are limited. This study retrospectively assessed 17 523 patients with CHD undergoing GGT and CRP testing. They were divided into 3 groups according to GGT tertiles. The critical points for high CRP levels was 10.0 mg/L, which corresponded to the 75th percentile. Logistic regression analysis was used to analyze the association between GGT and CRP levels in CHD patients. The baseline analysis showed significant differences in related parameters among patients with CHD. Compared with GGT tertile 1 (TI ), the odds ratio (OR) of T3 for GGT in CHD patients was 2.15 (95% confidence interval [CI]: 1.96-2.36). The association between GGT and CRP was higher in males (OR: 2.23; 95% CI: 1.98-2.52) than in females (OR: 2.18; 95% CI: 1.89-2.51). This study showed an association between serum GGT and CRP levels in patients with CHD. GGT may be an inflammatory marker and an additional measure for assessing cardiovascular risk.
C1 [He, Yuanyuan; Huang, Mengnan; Li, Zhu; Cheng, Qi; Liu, Yijia; Xue, Xiaoxue; Xu, Yilan; Zheng, Yanchao; Li, Lin; Gao, Shan; Yu, Chunquan] Tianjin Univ Tradit Chinese Med, Tianjin, Peoples R China.
C3 Tianjin University of Traditional Chinese Medicine
RP Yu, CN (corresponding author), Tianjin Univ Tradit Chinese Med, Tianjin, Peoples R China.; Li, L; Gao, S (corresponding author), Tianjin Univ Tradit Chinese Med, Tianjin 301617, Peoples R China.
EM llbianji@163.com; bianjibugs@163.com; ycqtjutcm@foxmail.com
RI LI, LIN/ABF-3496-2022; Xu, Alan/R-2683-2018
FU National Basic Research Program of China [2014CB542902]
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: This work
   was supported by the National Basic Research Program of China (973
   projects, grant number2014CB542902).
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NR 30
TC 1
Z9 1
U1 0
U2 7
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0003-3197
EI 1940-1574
J9 ANGIOLOGY
JI Angiology
PD AUG
PY 2023
VL 74
IS 7
BP 680
EP 686
DI 10.1177/00033197221121013
EA SEP 2022
PG 7
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA J8TY8
UT WOS:000851299800001
PM 36066238
DA 2025-06-11
ER

PT J
AU Vallée, A
AF Vallee, Alexandre
TI Arterial Stiffness and the Canonical WNT/β-catenin Pathway
SO CURRENT HYPERTENSION REPORTS
LA English
DT Review
DE Hypertension; Arterial stiffness; Pulse wave velocity; WNT/beta-catenin
   pathway; Aging; Inflammation; Blood pressure; Diabetes mellitus;
   Vascular calcification
ID CHRONIC KIDNEY-DISEASE; WNT SIGNALING PATHWAY; SERUM SCLEROSTIN LEVELS;
   SMOOTH-MUSCLE-CELLS; PULSE-WAVE VELOCITY; ALL-CAUSE MORTALITY; VASCULAR
   CALCIFICATION; METABOLIC SYNDROME; OXIDATIVE STRESS; BETA-CATENIN
AB Purpose of Review Arterial stiffness (AS) was mainly associated with cardiovascular morbidity and mortality in a hypertensive patient. Some risk factors contribute to the development of AS, such as aging, high blood pressure, vascular calcification, inflammation, and diabetes mellitus. The WNT/beta-catenin pathway is implicated in numerous signaling and regulating pathways, including embryogenesis, cell proliferation, migration and polarity, apoptosis, and organogenesis. The activation of the WNT/beta-catenin pathway is associated with the development of these risk factors.
   Recent Findings Aortic pulse wave velocity (PWV) is measured to determine AS, and in peripheral artery disease patients, PWV is higher than controls. An augmentation in PWV by 1 m/s has been shown to increase the risk of cardiovascular events by 14%. AS measured by PWV is characterized by the deregulation of the WNT/beta-catenin pathway by the inactivation of its two inhibitors, i.e., DKK1 and sclerostin.
   Summary Thus, this review focuses on the role of the WNT/beta-catenin pathway which contributes to the development of arterial stiffness.
C1 [Vallee, Alexandre] Foch Hosp, Dept Epidemiol Data Biostat, Delegat Clin Res & Innovat, F-92150 Suresnes, France.
C3 Hospital Foch
RP Vallée, A (corresponding author), Foch Hosp, Dept Epidemiol Data Biostat, Delegat Clin Res & Innovat, F-92150 Suresnes, France.
EM alexandre.g.vallee@gmail.com
RI Vallée, Alexandre/AEA-9496-2022
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NR 149
TC 4
Z9 4
U1 3
U2 9
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1522-6417
EI 1534-3111
J9 CURR HYPERTENS REP
JI Curr. Hypertens. Rep.
PD NOV
PY 2022
VL 24
IS 11
BP 499
EP 507
DI 10.1007/s11906-022-01211-7
EA JUN 2022
PG 9
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 5I4CU
UT WOS:000814043700001
PM 35727523
DA 2025-06-11
ER

PT J
AU Salehi, B
   Quispe, C
   Imran, M
   Ul-Haq, I
   Zivkovic, J
   Abu-Reidah, IM
   Sen, S
   Taheri, Y
   Acharya, K
   Azadi, H
   Contreras, MD
   Segura-Carretero, A
   Mnayer, D
   Sethi, G
   Martorell, M
   Razis, AFA
   Sunusi, U
   Kamal, RM
   Suleria, HAR
   Sharifi-Rad, J
AF Salehi, Bahare
   Quispe, Cristina
   Imran, Muhammad
   Ul-Haq, Iahtisham
   Zivkovic, Jelena
   Abu-Reidah, Ibrahim M.
   Sen, Surjit
   Taheri, Yasaman
   Acharya, Krishnendu
   Azadi, Hamed
   del Mar Contreras, Maria
   Segura-Carretero, Antonio
   Mnayer, Dima
   Sethi, Gautam
   Martorell, Miquel
   Abdull Razis, Ahmad Faizal
   Sunusi, Usman
   Kamal, Ramla Muhammad
   Rasul Suleria, Hafiz Ansar
   Sharifi-Rad, Javad
TI Nigella Plants - Traditional Uses, Bioactive Phytoconstituents,
   Preclinical and Clinical Studies
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Review
DE Nigella; cancer; pharmacological properties; functional ingredients;
   metabolic syndrome; thymoquinone
ID L. ESSENTIAL OIL; SATIVA SEED EXTRACT; MEDICINAL-PLANTS; OXIDATIVE
   STRESS; DOUBLE-BLIND; BLACK CUMIN; CHEMICAL-COMPOSITION; ANTICANCER
   PROPERTIES; PHENOLIC-COMPOUNDS; IN-VITRO
AB Nigella is a small genus of the family Ranunculaceae, which includes some popular species due to their culinary and medicinal properties, especially in Eastern Europe, Middle East, Western, and Central Asia. Therefore, this review covers the traditional uses and phytochemical composition of Nigella and, in particular, Nigella sativa. The pharmacological studies reported in vitro, in vivo, and in humans have also been reviewed. One of the main strength of the use of Nigella is that the seeds are rich in the omega-6 fatty acid linoleic acid and provide an extra-source of dietary phytochemicals, including the bioactive thymoquinone, and characteristics saponins, alkaloids, and flavonoids. Among Nigella species, N. sativa L. is the most studied plant from the genus. Due to the phytochemical composition and pharmacological properties, the seed and seed oil from this plant can be considered as good candidates to formulate functional ingredients on the basis of folklore and scientific knowledge. Nonetheless, the main limations are that more studies, especially, clinical trials are required to standardize the results, e.g. to establish active molecules, dosage, chemical profile, long-term effects and impact of cooking/incorporation into foods.
C1 [Salehi, Bahare] Shahid Beheshti Univ Med Sci, Med Eth & Law Res Ctr, Tehran, Iran.
   [Quispe, Cristina] Univ Arturo Prat, Fac Ciencias Salud, Iquique, Chile.
   [Imran, Muhammad] Univ Lahore, Univ Inst Diet & Nutr Sci, Fac Allied Hlth Sci, Lahore, Pakistan.
   [Ul-Haq, Iahtisham] Imperial Coll Business Studies, Fac Hlth & Allied Sci, Dept Diet & Nutr Sci, Lahore, Pakistan.
   [Zivkovic, Jelena] Inst Med Plants Res Dr Josif Pancic, Belgrade, Serbia.
   [Abu-Reidah, Ibrahim M.] Mem Univ Newfoundland, Dept Environm Sci Boreal Ecosyst Res Initiat, Corner Brook, NF, Canada.
   [Sen, Surjit; Acharya, Krishnendu] Univ Calcutta, Dept Bot, Mol & Appl Mycol & Plant Pathol Lab, Kolkata, India.
   [Sen, Surjit] Fakir Chand Coll, Dept Bot, Diamond Harbour, India.
   [Taheri, Yasaman; Sharifi-Rad, Javad] Shahid Beheshti Univ Med Sci, Phytochem Res Ctr, Tehran, Iran.
   [Azadi, Hamed] Univ Tehran, Coll Aburaihan, Dept Agron & Plant Breeding Sci, Tehran, Iran.
   [del Mar Contreras, Maria] Univ Jaen, Dept Chem Environm & Mat Engn, Jaen, Spain.
   [Segura-Carretero, Antonio] Univ Granada, Dept Analyt Chem, Fac Sci, Granada, Spain.
   [Segura-Carretero, Antonio] Res & Dev Funct Food Ctr CIDAF, Bioreg Bldg,Hlth Sci Technol Pk, Granada, Spain.
   [Mnayer, Dima] Lebanese Univ, Fac Sci, Beirut, Lebanon.
   [Sethi, Gautam] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Pharmacol, Singapore, Singapore.
   [Martorell, Miquel] Univ Concepcion, Fac Pharm, Dept Nutr & Dietet, Concepcion, Chile.
   [Martorell, Miquel] Univ Concepcion, Ctr Hlth Living, Concepcion, Chile.
   [Martorell, Miquel] Univ Concepcion, Unidad Desarrollo Tecnol, UDT, Concepcion, Chile.
   [Abdull Razis, Ahmad Faizal] Univ Putra Malaysia, Fac Food Sci & Technol, Dept Food Sci, Serdang, Malaysia.
   [Abdull Razis, Ahmad Faizal; Sunusi, Usman; Kamal, Ramla Muhammad] Univ Putra Malaysia, Inst Biosci, Nat Med & Prod Res Lab, Serdang, Malaysia.
   [Sunusi, Usman] Bayero Univ Kano, Dept Biochem, Kano, Nigeria.
   [Kamal, Ramla Muhammad] Fed Univ Dutse, Dept Pharmacol, Dutse, Nigeria.
   [Rasul Suleria, Hafiz Ansar] Univ Melbourne, Dept Agr & Food Syst, Melbourne, Vic, Australia.
   [Sharifi-Rad, Javad] Univ Azuay, Fac Med, Cuenca, Ecuador.
C3 Shahid Beheshti University Medical Sciences; Universidad Arturo Prat;
   University of Lahore; Memorial University Newfoundland; University of
   Calcutta; Shahid Beheshti University Medical Sciences; University of
   Tehran; Universidad de Jaen; University of Granada; Lebanese University;
   National University of Singapore; Universidad de Concepcion; Universidad
   de Concepcion; Universidad de Concepcion; Universiti Putra Malaysia;
   Universiti Putra Malaysia; Bayero University; University of Melbourne;
   Universidad del Azuay
RP Sharifi-Rad, J (corresponding author), Shahid Beheshti Univ Med Sci, Phytochem Res Ctr, Tehran, Iran.; Contreras, MD (corresponding author), Univ Jaen, Dept Chem Environm & Mat Engn, Jaen, Spain.; Razis, AFA (corresponding author), Univ Putra Malaysia, Fac Food Sci & Technol, Dept Food Sci, Serdang, Malaysia.; Razis, AFA (corresponding author), Univ Putra Malaysia, Inst Biosci, Nat Med & Prod Res Lab, Serdang, Malaysia.; Sharifi-Rad, J (corresponding author), Univ Azuay, Fac Med, Cuenca, Ecuador.
EM mar.contreras.gamez@gmail.com; madfaizal@upm.edu.my;
   javad.sharifirad@gmail.com
RI del Mar Contreras, María/K-9122-2014; Suleria, Hafiz Ansar
   Rasul/D-3385-2013; SEN, SURJIT/AAS-4013-2021; Razis, Ahmad/F-8079-2014;
   Imran, Muhammad/JEF-6364-2023; Abu-Reidah, Ibrahim/C-7957-2013; Khan,
   Muhammad/ABB-7077-2020; Acharya, Krishnendu/G-2317-2012; Sethi,
   Gautam/F-2372-2011; Martorell, Miquel/H-8490-2014; segura Carretero,
   Antonio/B-6867-2014; Sharifi-Rad, Javad/D-5747-2016
OI CONTRERAS, MARIA DEL MAR/0000-0002-3407-0088; Acharya,
   Krishnendu/0000-0003-1193-1823; Muhammad Kamal,
   Ramla/0000-0003-2919-9124; Sethi, Gautam/0000-0002-8677-8475; Taheri,
   Yasaman/0000-0002-0836-236X; Martorell, Miquel/0000-0003-3183-7623;
   Zivkovic, Jelena/0000-0002-9684-2637; Suleria, Hafiz Ansar
   Rasul/0000-0002-2450-0830; segura Carretero,
   Antonio/0000-0002-5564-5338; SEN, SURJIT/0000-0002-4038-7292;
   Sharifi-Rad, Javad/0000-0002-7301-8151
FU Programa Operativo FEDER 2014-2020 [1260905]; Consejeria de Economia y
   Conocimiento de la Junta de Andalucia [1260905]; CONICYT PIA/APOYO CCTE
   [AFB170007]
FX M. d. M. Contreras thanks the FEDER UJA project 1260905 funded by
   "Programa Operativo FEDER 2014-2020" and "Consejeria de Economia y
   Conocimiento de la Junta de Andalucia". This work was also supported by
   CONICYT PIA/APOYO CCTE AFB170007.
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NR 227
TC 45
Z9 49
U1 3
U2 23
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD APR 26
PY 2021
VL 12
AR 625386
DI 10.3389/fphar.2021.625386
PG 26
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA RZ4YD
UT WOS:000648602900001
PM 33981219
OA Green Accepted, Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Yuan, Y
   Zhou, JH
   Zheng, YF
   Xu, ZC
   Li, YQ
   Zhou, S
   Zhang, CS
AF Yuan, Yuan
   Zhou, Jinhui
   Zheng, Yanfen
   Xu, Zongchang
   Li, Yiqiang
   Zhou, San
   Zhang, Chengsheng
TI Beneficial effects of polysaccharide-rich extracts from Apocynum
   venetum leaves on hypoglycemic and gut microbiota in type 2 diabetic
   mice
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Article
DE Polysaccharide; Apocynum venetum; Diabetes; Hypoglycemic; Gut microbiota
ID CHAIN FATTY-ACIDS; OXIDATIVE STRESS; DIET; STREPTOZOTOCIN; L.;
   ASSOCIATION; JAPONICA; LUOBUMA; PROTECT; FIBER
AB Diabetes is one of the most concerned metabolic diseases worldwide and threaten public health. In the present work, two polysaccharide-rich extracts from Apocynum venetum leaves were extracted using distilled water and alkaline solution (0.05 M NaOH), and fully characterized. Hypoglycemic and hypolipidemic effects of two polysaccharide-rich extracts on high-fat diet and streptozocin-induced type 2 diabetic mice were investigated. Treatment of alkaline extracted polysaccharide-rich products significantly decreased the levels of fasting blood glucose, serum insulin, glycated serum protein, as well as serum lipids profiles including total cholesterol, triacylglycerols, low-density lipoprotein cholesterol, and nonesterified fatty acid. Meanwhile, the reduced glycogen contents in liver were prominently improved, and the oxidative damage were markedly ameliorated by alkaline extracted polysaccharide products in diabetic mice. Furthermore, both polysaccharide-rich extracts could reverse the gut microbiota dysbiosis in diabetic mice by increasing the abundance of genera Odoribacter, Anaeroplasma, Parasutterella, and Muribaculum; while by decreasing the abundance of genera Enterococcus, Klebsiella, and Aerococcus. This study provides new sights for exploitation of Apocynum venetum extracts as a promising anti-diabetic nutraceutical for the treatment of type 2 diabetes and metabolic syndrome.
C1 [Yuan, Yuan; Zhou, Jinhui; Zheng, Yanfen; Xu, Zongchang; Li, Yiqiang; Zhang, Chengsheng] Chinese Acad Agr Sci, Marine Agr Res Ctr, Tobacco Res Inst, Qingdao 266101, Peoples R China.
   [Zhou, Jinhui; Zhou, San] Qingdao Univ, Sch Pharm, Dept Pharmcognosy, Qingdao 266021, Peoples R China.
C3 Chinese Academy of Agricultural Sciences; Tobacco Research Institute,
   CAAS; Qingdao University
RP Zhang, CS (corresponding author), Chinese Acad Agr Sci, Marine Agr Res Ctr, Tobacco Res Inst, Qingdao 266101, Peoples R China.; Zhou, S (corresponding author), Qingdao Univ, Sch Pharm, Dept Pharmcognosy, Qingdao 266021, Peoples R China.
EM zhousan3@163.com; Zhangchengsheng@caas.cn
RI Zheng, Yanfen/GMW-4373-2022
FU Doctor Foundation of Shandong [ZR2019BC073]; National Science Foundation
   of China [31900276]; Agricultural Science and Technology Innovation
   Program of China [ASTIP-TRIC07]
FX This work was supported by the Doctor Foundation of Shandong
   (ZR2019BC073), by the National Science Foundation of China (31900276),
   by the Agricultural Science and Technology Innovation Program of China
   (ASTIP-TRIC07).
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NR 55
TC 76
Z9 83
U1 12
U2 156
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD JUL
PY 2020
VL 127
AR 110182
DI 10.1016/j.biopha.2020.110182
PG 9
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA MC7WW
UT WOS:000543493200064
PM 32361160
OA gold
DA 2025-06-11
ER

PT J
AU Pretorius, E
   Bester, J
   Vermeulen, N
   Alummoottil, S
   Soma, P
   Buys, AV
   Kell, DB
AF Pretorius, Etheresia
   Bester, Janette
   Vermeulen, Natasha
   Alummoottil, Sajee
   Soma, Prashilla
   Buys, Antoinette V.
   Kell, Douglas B.
TI Poorly controlled type 2 diabetes is accompanied by significant
   morphological and ultrastructural changes in both erythrocytes and in
   thrombin-generated fibrin: implications for diagnostics
SO CARDIOVASCULAR DIABETOLOGY
LA English
DT Article
DE Type II diabetes; Erythrocytes; Deferoxamine; Deferasirox
ID BODY IRON STORES; NF-KAPPA-B; INDUCED OXIDATIVE STRESS; SERUM FERRITIN;
   METABOLIC SYNDROME; ENDOTHELIAL DYSFUNCTION; SCANNING-ELECTRON;
   TNF-ALPHA; MOLECULAR-MECHANISMS; ANTIPLATELET THERAPY
AB We have noted in previous work, in a variety of inflammatory diseases, where iron dysregulation occurs, a strong tendency for erythrocytes to lose their normal discoid shape and to adopt a skewed morphology (as judged by their axial ratios in the light microscope and by their ultrastructure in the SEM). Similarly, the polymerization of fibrinogen, as induced in vitro by added thrombin, leads not to the common 'spaghetti-like' structures but to dense matted deposits. Type 2 diabetes is a known inflammatory disease. In the present work, we found that the axial ratio of the erythrocytes of poorly controlled (as suggested by increased HbA1c levels) type 2 diabetics was significantly increased, and that their fibrin morphologies were again highly aberrant. As judged by scanning electron microscopy and in the atomic force microscope, these could be reversed, to some degree, by the addition of the iron chelators deferoxamine (DFO) or deferasirox (DFX). As well as their demonstrated diagnostic significance, these morphological indicators may have prognostic value.
C1 [Pretorius, Etheresia; Bester, Janette; Vermeulen, Natasha; Alummoottil, Sajee; Soma, Prashilla] Univ Pretoria, Fac Hlth Sci, Dept Physiol, ZA-0007 Arcadia, South Africa.
   [Buys, Antoinette V.] Univ Pretoria, Unit Microscopy & Microanalysis, ZA-0002 Pretoria, South Africa.
   [Kell, Douglas B.] Univ Manchester, Sch Chem, Manchester M1 7DN, Lancs, England.
   [Kell, Douglas B.] Univ Manchester, Manchester Inst Biotechnol, Manchester M1 7DN, Lancs, England.
C3 University of Pretoria; University of Pretoria; University of
   Manchester; University of Manchester
RP Pretorius, E (corresponding author), Univ Pretoria, Fac Hlth Sci, Dept Physiol, Private Bag X323, ZA-0007 Arcadia, South Africa.
EM resia.pretorius@up.ac.za; dbk@manchester.ac.uk
RI Pretorius, Etheresia/P-2978-2016; Kell, Douglas/E-8318-2011
OI Lensink, Antonia Vergina/0000-0002-5206-3877; Bester,
   Janette/0000-0002-8931-9194; Kell, Douglas/0000-0001-5838-7963;
   Pretorius, Etheresia/0000-0002-9108-2384
FU Biotechnology and Biological Sciences Research Council [BB/L025752/1];
   National Research Foundation (NRF) of South Africa; BBSRC [BB/L025752/1]
   Funding Source: UKRI
FX We thank the Biotechnology and Biological Sciences Research Council
   (grant BB/L025752/1) as well as the National Research Foundation (NRF)
   of South Africa for supporting this collaboration.
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NR 160
TC 69
Z9 72
U1 3
U2 19
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1475-2840
J9 CARDIOVASC DIABETOL
JI Cardiovasc. Diabetol.
PD MAR 8
PY 2015
VL 14
AR 30
DI 10.1186/s12933-015-0192-5
PG 20
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism
GA CD6LS
UT WOS:000351201200001
PM 25848817
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Koizumi, M
   Watanabe, H
   Kaneko, Y
   Iino, K
   Ishida, M
   Kosaka, T
   Motohashi, Y
   Ito, H
AF Koizumi, Megumi
   Watanabe, Hiroyuki
   Kaneko, Yoshihiro
   Iino, Kenji
   Ishida, Masaru
   Kosaka, Toshimitsu
   Motohashi, Yutaka
   Ito, Hiroshi
TI Impact of obesity on plasma B-type natriuretic peptide levels in
   Japanese community-based subjects
SO HEART AND VESSELS
LA English
DT Article
DE BMI; Abdominal circumference; B-type natriuretic peptide; Japanese
ID CARDIOVASCULAR-DISEASE RISK; HEART-FAILURE; WAIST CIRCUMFERENCE;
   CIRCULATING LEVELS; ADIPONECTIN LEVEL; FAT ACCUMULATION; WALL STRESS;
   BODY-MASS; ASSOCIATION; BNP
AB The plasma B-type natriuretic peptide (BNP) concentration was recently shown to be inversely correlated with body mass index (BMI). However, very few attempts have been made to associate abdominal obesity and BNP in the Japanese general population. Here, we conducted a cross-sectional study, and examined 339 male and 429 female residents without heart disease in a rural Japanese community who received an annual health checkup in 2006. BNP was inversely associated with both BMI and abdominal circumference (AC) in the age-adjusted regression analysis ( < 0.05). Following adjustment for traditional risk factors, multiple regression analysis revealed that BNP was negatively correlated with AC ( < 0.05), but not BMI. Although metabolic syndrome was not associated with BNP levels, AC had an influence on low BNP levels in the multiple regression analysis using both AC and BMI concurrently ( < 0.05 for AC and > 0.60 for BMI). These effects were more prominent in men than in women. Collectively, plasma BNP levels are inversely related with obesity, as measured by AC, in Japanese community-based subjects.
C1 [Koizumi, Megumi; Watanabe, Hiroyuki; Iino, Kenji; Ishida, Masaru; Kosaka, Toshimitsu; Ito, Hiroshi] Akita Univ, Fac Med, Div Cardiovasc Med, Dept Internal Med, Akita 0108543, Japan.
   [Kaneko, Yoshihiro; Motohashi, Yutaka] Akita Univ, Grad Sch Med, Dept Publ Hlth, Akita 0108543, Japan.
C3 Akita University; Akita University
RP Ito, H (corresponding author), Akita Univ, Fac Med, Div Cardiovasc Med, Dept Internal Med, 1-1-1 Hondo, Akita 0108543, Japan.
EM hitomed2@gipc.akita-u.ac.jp
RI Ishida, Masaru/LZF-0871-2025
FU O-town, Akita prefecture, Japan
FX We thank M. Sugawara, T. Ono and the healthcare staff of O-town, Akita
   prefecture, Japan, for supporting this study.
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NR 33
TC 20
Z9 22
U1 1
U2 3
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0910-8327
EI 1615-2573
J9 HEART VESSELS
JI Heart Vessels
PD MAY
PY 2012
VL 27
IS 3
BP 287
EP 294
DI 10.1007/s00380-011-0143-3
PG 8
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 943RH
UT WOS:000304142400008
PM 21526421
DA 2025-06-11
ER

PT J
AU Hamad, EM
   Taha, SH
   Abou Dawood, AGI
   Sitohy, MZ
   Abdel-Hamid, M
AF Hamad, Essam M.
   Taha, Soad H.
   Abou Dawood, Abdel-Gawad I.
   Sitohy, Mahmoud Z.
   Abdel-Hamid, Mahmoud
TI Protective effect of whey proteins against nonalcoholic fatty liver in
   rats
SO LIPIDS IN HEALTH AND DISEASE
LA English
DT Article
ID SUPPLEMENTATION; GLUTATHIONE; STEATOHEPATITIS; OBESITY; DISEASE
AB Background: Nonalcoholic fatty liver disease (NAFLD) is the hepatic manifestation of the metabolic syndrome and can vary from hepatic steatosis to end-stage liver disease. It is the most common liver disease and its prevalence is increasing worldwide. In the present study, the effect of whey proteins on some parameters of NAFLD was investigated.
   Results: Oral administration of the studied whey proteins products reduced the final body weight of rats. There was a significant reduction effect (P < 0.05) of the tested proteins on hepatic triglycerides, liver enzymes (ALT and AST), lipid peroxidation (malondialdehyde level) and serum glucose. Feeding on whey proteins caused an increase in the reduced glutathione. Hepatic content of reduced glutathione was not affected by any of the used whey proteins, but it showed an increasing tendency (P > 0.05). Liver histology showed an improvement of fatty infiltration in hepatocytes from whey protein groups and gives the histology of liver a normal appearance.
   Conclusions: The obtained results indicate a possible role for oral administration of whey proteins in the regulation of liver biochemistries in a rat's model of NAFLD. This regulatory effect of whey proteins was accompanied by an improvement in fatty infiltration in hepatocytes and a reduction of oxidative stress parameters.
C1 [Hamad, Essam M.; Taha, Soad H.; Abou Dawood, Abdel-Gawad I.; Abdel-Hamid, Mahmoud] Cairo Univ, Dept Dairy Sci, Fac Agr, Cairo, Egypt.
   [Sitohy, Mahmoud Z.] Zagazig Univ, Fac Agr, Dept Biochem, Zagazig, Egypt.
C3 Egyptian Knowledge Bank (EKB); Cairo University; Egyptian Knowledge Bank
   (EKB); Zagazig University
RP Abdel-Hamid, M (corresponding author), Cairo Univ, Dept Dairy Sci, Fac Agr, Cairo, Egypt.
EM mahmoudah3@yahoo.com
RI Sitohy, Mahmoud/ABE-8495-2021; Abdel-Hamid, Mahmoud/AAB-2174-2020;
   Hamad, Essam/HIK-0482-2022
OI Abdel-Hamid, Mahmoud/0000-0003-2833-2720; Sitohy,
   Mahmoud/0000-0001-6623-4860; Hamad, Essam/0000-0002-0071-3153
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U1 1
U2 11
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1476-511X
J9 LIPIDS HEALTH DIS
JI Lipids Health Dis.
PD APR 13
PY 2011
VL 10
AR 57
DI 10.1186/1476-511X-10-57
PG 7
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA 765MB
UT WOS:000290709900001
PM 21489294
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Catalano, G
   Chatzipanagiotou, OP
   Kawashima, J
   Pawlik, TM
AF Catalano, Giovanni
   Chatzipanagiotou, Odysseas P.
   Kawashima, Jun
   Pawlik, Timothy M.
TI Metabolic-associated steatotic liver disease and hepatocellular
   carcinoma
SO EXPERT OPINION ON PHARMACOTHERAPY
LA English
DT Review
DE Hepatocellular carcinoma; MASLD; NAFLD; risk factors; metabolic syndrome
ID HEPATITIS-B; NONALCOHOLIC STEATOHEPATITIS; SURGICAL OUTCOMES; OBESITY;
   NAFLD; NASH; PATHOGENESIS; PHENOTYPE; EXERCISE; ALCOHOL
AB IntroductionMetabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) has been introduced as a superior term to describe steatosis on a background of metabolic dysregulation and is slated to become the leading cause of HCC worldwide, as the incidence of metabolic comorbidities is increasing. As such, MASLD has evolved into an important public health issue, potentially leading to higher rates of liver mortality and end-stage liver disease. To this end, understanding the association between MASLD and HCC may allow for the identification of better interventions and novel therapeutic strategies.Areas coveredThe authors provide a review of current knowledge on HCC development among patients with MASLD, with insights into molecular pathways and current and future therapeutic strategies.Expert opinionMASLD has a strong association with the risk of HCC development, as metabolic comorbidities induce dysregulation in molecular pathways, leading to insulin-resistance, oxidative stress, and chronic inflammation, thus causing progression to cirrhosis and eventually to HCC. Therapeutic strategies focused on reducing diabetes-associated complications, as well as the prevalence of obesity and smoking can improve patient outcomes and reduce HCC incidence. Future studies on the molecular background of metabolic alterations may help devise new therapeutic approaches aiming to improve the current management of MASLD-HCC.
C1 [Catalano, Giovanni; Chatzipanagiotou, Odysseas P.; Kawashima, Jun; Pawlik, Timothy M.] Ohio State Univ, Wexner Med Ctr, Dept Surg, Columbus, OH USA.
   [Catalano, Giovanni; Chatzipanagiotou, Odysseas P.; Kawashima, Jun; Pawlik, Timothy M.] James Comprehens Canc Ctr, Columbus, OH USA.
   [Catalano, Giovanni] Univ Verona, Dept Surg, Verona, Italy.
C3 University System of Ohio; Ohio State University; University System of
   Ohio; Ohio State University; James Cancer Hospital & Solove Research
   Institute; University of Verona
RP Pawlik, TM (corresponding author), Ohio State Univ, Urban Meyer III & Shelley Meyer Chair Canc Res, Wexner Med Ctr, Dept Surg, 395 W 12th Ave, Columbus, OH 43210 USA.
EM Tim.Pawlik@osumc.edu
RI Pawlik, Timothy/AAO-9335-2020; Chatzipanagiotou, Odysseas
   P/MYQ-8495-2025
OI Chatzipanagiotou, Odysseas P/0009-0006-8377-0263; Kawashima,
   Jun/0000-0003-1072-0776; Catalano, Giovanni/0000-0003-1440-7031
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NR 93
TC 1
Z9 1
U1 1
U2 1
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1465-6566
EI 1744-7666
J9 EXPERT OPIN PHARMACO
JI Expert Opin. Pharmacother.
PD NOV 21
PY 2024
VL 25
IS 17
BP 2283
EP 2291
DI 10.1080/14656566.2024.2426680
EA NOV 2024
PG 9
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA N3K2L
UT WOS:001353171900001
PM 39503379
DA 2025-06-11
ER

PT J
AU Dubey, P
   Reddy, S
   Sharma, K
   Johnson, S
   Hardy, G
   Dwivedi, AK
AF Dubey, Pallavi
   Reddy, Sireesha
   Sharma, Kunal
   Johnson, Sarah
   Hardy, Ghislain
   Dwivedi, Alok Kumar
TI Polycystic Ovary Syndrome, Insulin Resistance, and Cardiovascular
   Disease
SO CURRENT CARDIOLOGY REPORTS
LA English
DT Review
DE Polycystic ovary syndrome; Insulin resistance; Insulin signaling
   pathways; Cardiovascular disease; Atherosclerosis; Cardiovascular
   disease risk
ID IMPAIRED GLUCOSE-TOLERANCE; FLOW-MEDIATED DILATION; ALL-CAUSE MORTALITY;
   METABOLIC SYNDROME; FOLLOW-UP; NATIONWIDE POPULATION; DIABETES-MELLITUS;
   OXIDATIVE STRESS; RISK-FACTORS; WOMEN
AB Purpose of ReviewPolycystic ovary syndrome (PCOS) is a prevalent endocrine disorder in women of reproductive age. It has been associated with metabolic, reproductive, and psychiatric disorders. Despite its association with insulin resistance (IR) and cardiovascular disease (CVD) risk factors, the association between PCOS and CVD outcomes has been conflicting. This review reports the updated evidence between PCOS, insulin resistance, and CVD events.Recent FindingsIR is highly prevalent occurring in 50 to 95% of general and obese PCOS women. The etiology of PCOS involves IR and hyperandrogenism, which lead to CVD risk factors, subclinical CVD, and CVD outcomes. Multiple studies including meta-analysis confirmed a strong association between PCOS and CVD events including ischemic heart disease, stroke, atrial fibrillation, and diabetes, particularly among premenopausal women, and these associations were mediated by metabolic abnormalities.SummaryPCOS is highly familial and has substantial CVD risk and transgenerational effects regardless of obesity. A personalized approach to the CVD risk assessment and management of symptom manifestations should be conducted according to its phenotypes. Lifestyle modifications and reduction in environmental stressors should be encouraged for CVD prevention among PCOS women.
C1 [Dubey, Pallavi; Reddy, Sireesha; Sharma, Kunal; Hardy, Ghislain] Texas Tech Univ, Hlth Sci Ctr, Dept Obstet & Gynecol, El Paso, TX 79905 USA.
   [Johnson, Sarah] Texas Tech Univ Hlth Sci Ctr Paso, Paul L Foster Sch Med, El Paso, TX USA.
   [Dwivedi, Alok Kumar] Texas Tech Univ Hlth Sci Ctr El Paso, Dept Mol & Translat Med, El Paso, TX USA.
C3 Texas Tech University System; Texas Tech University; Texas Tech
   University Health Sciences Center El Paso; Texas Tech University System;
   Texas Tech University Health Sciences Center El Paso; Texas Tech
   University System; Texas Tech University Health Sciences Center El Paso
RP Dubey, P (corresponding author), Texas Tech Univ, Hlth Sci Ctr, Dept Obstet & Gynecol, El Paso, TX 79905 USA.
EM paldubey@ttuhsc.edu
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NR 108
TC 3
Z9 3
U1 1
U2 5
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1523-3782
EI 1534-3170
J9 CURR CARDIOL REP
JI Curr. Cardiol. Rep.
PD JUN
PY 2024
VL 26
IS 6
BP 483
EP 495
DI 10.1007/s11886-024-02050-5
EA APR 2024
PG 13
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA WI2H1
UT WOS:001196118200001
PM 38568339
DA 2025-06-11
ER

PT J
AU Buljeta, I
   Pichler, A
   Simunovic, J
   Kopjar, M
AF Buljeta, Ivana
   Pichler, Anita
   Simunovic, Josip
   Kopjar, Mirela
TI Beneficial Effects of Red Wine Polyphenols on Human Health:
   Comprehensive Review
SO CURRENT ISSUES IN MOLECULAR BIOLOGY
LA English
DT Review
DE polyphenols; red wine; human health; cardiovascular diseases;
   chemoprevention effect; gut microbiota
ID METABOLIC SYNDROME; GUT MICROBIOTA; BLOOD-PRESSURE; CONSUMPTION;
   EXTRACTS; RESVERATROL; GRAPE; EXPRESSION; CARCINOGENESIS; PERFORMANCE
AB Polyphenols are secondary plant metabolites synthesized during the development of the grape berry as a response to stress conditions. They are important constituents in red wines that contribute to the sensory properties and antioxidant activity of wines. Due to the development of highly sophisticated analytical devices, it is now possible to characterize the structure of highly polymerized polyphenols and obtain a full polyphenol profile of red wines. Red wine polyphenols include the ones present in grapes as well as new polyphenol products formed during the winemaking process. Among them, the most important groups and their representatives are flavanols (catechin), stilbenes (trans-resveratrol), flavonols (quercetin) and hydroxybenzoic acids (gallic acid). It is known that polyphenols exhibit beneficial effects on human health, such as anti-inflammatory, anticarcinogenic and cardio-protective effects. Many studies have been conducted on the health effects of red wine polyphenols in cancer chemopreventive activities, neuroprotective effects and impact on cardiovascular diseases, gut microbiota in humans, etc. This review will provide major scientific findings on the impact of red wine polyphenols on human health as well as a review of polyphenols present in red wines and their main features.
C1 [Buljeta, Ivana; Pichler, Anita; Kopjar, Mirela] Josip Juraj Strossmayer Univ, Fac Food Technol, F Kuhaca 18, Osijek 31000, Croatia.
   [Simunovic, Josip] North Carolina State Univ, Dept Food Bioproc & Nutr Sci, Raleigh, NC 27695 USA.
C3 University of JJ Strossmayer Osijek; North Carolina State University
RP Kopjar, M (corresponding author), Josip Juraj Strossmayer Univ, Fac Food Technol, F Kuhaca 18, Osijek 31000, Croatia.
EM mirela.kopjar@ptfos.hr
RI Pichler, Anita/GLN-2604-2022
OI Simunovic, Josip/0000-0001-7594-512X; Buljeta,
   Ivana/0000-0001-9357-8909; Pichler, Anita/0000-0002-5437-9111
FU "Re-search Cooperability" Program of the Croatian Science Foundation -
   European Union's European Social Fund [PZS-2019-02-1595]; Croatian
   Science Foundation [PZS-2019-02-1595, IP-2019-04-5749]; European Union's
   European Social Fund
FX This work was part of project PZS-2019-02-1595 (which was fully
   supported by the "Re-search Cooperability" Program of the Croatian
   Science Foundation and funded by the European Union's European Social
   Fund under the Operational Program for Efficient Human Resources
   2014-2020) and project IP-2019-04-5749 (which was fully supported by the
   Croatian Science Foundation).
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NR 85
TC 47
Z9 49
U1 16
U2 96
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
SN 1467-3037
EI 1467-3045
J9 CURR ISSUES MOL BIOL
JI Curr. Issues Mol. Biol.
PD FEB
PY 2023
VL 45
IS 2
BP 782
EP 798
DI 10.3390/cimb45020052
PG 17
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 9H6EJ
UT WOS:000938923700001
PM 36825997
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Zhou, YJ
   Xu, N
   Zhang, XC
   Zhu, YY
   Liu, SW
   Chang, YN
AF Zhou, Ying-Jun
   Xu, Nuo
   Zhang, Xiao-Chen
   Zhu, Yu-Yan
   Liu, Shao-Wei
   Chang, Ya-Ning
TI Chrysin Improves Glucose and Lipid Metabolism Disorders by Regulating
   the AMPK/PI3K/AKT Signaling Pathway in Insulin-Resistant HepG2 Cells and
   HFD/STZ-Induced C57BL/6J Mice
SO JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
LA English
DT Article
DE AKT; AMPK; chrysin; glucose metabolism; lipid metabolism
ID INHIBITS HEPATIC GLUCONEOGENESIS; INCREASES GLYCOGEN-SYNTHESIS; PI3K/AKT
   PATHWAY; DIABETIC MICE; FLAVONOIDS; RECEPTORS; AMPK
AB Natural products with minor side effects have been reported to be an effective adjuvant therapy for glucose and lipid metabolism disorders. Chrysin, a flavone, has a wide range of physiological effects, such as antioxidant, anti-inflammatory, anti-diabetes, anti-hyperlipidemia, and hepatoprotective. This study was designed to explore the effects and mechanism of chrysin on metabolic syndrome using insulin-resistant HepG2 cells and HFD/STZ-induced C57BL/6J mice. The results indicated that chrysin significantly decreased insulin resistance, oxidative stress, inflammation, and liver injury. In addition, chrysin improved glycogen synthesis and fatty acid oxidation and inhibited gluconeogenesis and fatty acid synthesis by regulating GSK3 beta, G6Paes, PEPCK, SREBP1, FAS, and ACC1. Furthermore, the results of western blot and real-time PCR experiments demonstrated that chrysin modulated glucose and lipid metabolism through the AMPK/PI3K/AKT signaling pathway. Treatment with the AMPK inhibitor verified that AMPK activation is positively correlated with chrysin activity on glycolipid metabolism. This study confirms that chrysin is a potential treatment for glucose and lipid metabolism disorders.
C1 [Zhou, Ying-Jun; Xu, Nuo; Zhang, Xiao-Chen; Zhu, Yu-Yan; Liu, Shao-Wei; Chang, Ya-Ning] East China Univ Sci & Technol, Coll Bioengn, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China.
C3 East China University of Science & Technology
RP Chang, YN (corresponding author), East China Univ Sci & Technol, Coll Bioengn, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China.
EM changyn@ecust.edu.cn
RI Chang, Ya-Ning/L-1150-2019
OI Zhou, Yingjun/0000-0003-3631-4004
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NR 41
TC 85
Z9 90
U1 10
U2 174
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0021-8561
EI 1520-5118
J9 J AGR FOOD CHEM
JI J. Agric. Food Chem.
PD MAY 26
PY 2021
VL 69
IS 20
BP 5618
EP 5627
DI 10.1021/acs.jafc.1c01109
EA MAY 2021
PG 10
WC Agriculture, Multidisciplinary; Chemistry, Applied; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture; Chemistry; Food Science & Technology
GA SL9HM
UT WOS:000657225400005
PM 33979145
DA 2025-06-11
ER

PT J
AU Nocella, C
   Cammisotto, V
   Fianchini, L
   D'Amico, A
   Novo, M
   Castellani, V
   Stefanini, L
   Violi, F
   Carnevale, R
AF Nocella, Cristina
   Cammisotto, Vittoria
   Fianchini, Luca
   D'Amico, Alessandra
   Novo, Marta
   Castellani, Valentina
   Stefanini, Lucia
   Violi, Francesco
   Carnevale, Roberto
TI Extra Virgin Olive Oil and Cardiovascular Diseases: Benefits for Human
   Health
SO ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS
LA English
DT Review
DE Antioxidant; anti-atherosclerotic nutrient; endothelial dysfunction;
   extra virgin olive oil; cardiovascular disease; nutraceutical
ID MEDITERRANEAN DIET IMPROVES; OXIDATIVE STRESS; NITRIC-OXIDE;
   DENSITY-LIPOPROTEIN; METABOLIC SYNDROME; SUPEROXIDE-PRODUCTION;
   BLOOD-PRESSURE; RISK-FACTORS; STYLE DIET; LDL
AB Background and Objective: The cardioprotective properties of Mediterranean Diet were demonstrated for the first time from the Seven Country Study. In the last few decades, numerous epidemiological studies, as well as intervention trial, confirmed this observation, pointing out the close relationship between the Mediterranean diet and cardiovascular diseases. In this context, extra virgin olive oil (EVOO), the most representative component of this diet, seems to be relevant in lowering the incidence of cardiovascular events, including myocardial infarction and stroke. From a chemical point of view, 98-99% of the total weight of EVOO is represented by fatty acids, especially monounsaturated fatty acids such as oleic acid. Tocopherols, polyphenols and other minor constituents represent the remaining 1-2%. All these components may potentially contribute to "health maintenance" with their beneficial effects by EVOOO.
   Methods: Studies that examined the effect of EVOO supplementation in healthy subjects and in individuals at cardiovascular risk were included.
   Conclusion: The studies analyzed demonstrated the role of EVOO as anti-inflammatory, antioxidant and vasodilatory nutrient that may contribute to lower the atherosclerotic burden.
C1 [Nocella, Cristina; D'Amico, Alessandra; Carnevale, Roberto] Sapienza Univ Rome, Dept Med Surg Sci & Biotechnol, Rome, Italy.
   [Cammisotto, Vittoria; Fianchini, Luca; Novo, Marta; Castellani, Valentina; Stefanini, Lucia; Violi, Francesco] Sapienza Univ Rome, Dept Internal Med & Med Specialties, Rome, Italy.
C3 Sapienza University Rome; Sapienza University Rome
RP Carnevale, R (corresponding author), Sapienza Univ Rome, Dept Med Surg Med Surg Sci & Biotechnol, Rome, Italy.
EM roberto.carnevale@uniroma1.it
RI Cammisotto, Vittoria/W-5910-2019; Violi, Francesco/K-1509-2016; D'Amico,
   Alessandra/IUN-1943-2023; Nocella, Cristina/K-2175-2016; stefanini,
   lucia/K-3992-2016; Carnevale, Roberto/JMC-1138-2023
OI Stefanini, Lucia/0000-0001-7420-301X; D'Amico,
   Alessandra/0000-0002-5571-4583; Castellani,
   Valentina/0000-0001-6455-4828
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NR 62
TC 97
Z9 99
U1 2
U2 47
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1871-5303
EI 2212-3873
J9 ENDOCR METAB IMMUNE
JI Endocr. Metab. Immune Disord.-Drug Targets
PY 2018
VL 18
IS 1
BP 4
EP 13
DI 10.2174/1871530317666171114121533
PG 10
WC Endocrinology & Metabolism; Immunology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Immunology; Pharmacology & Pharmacy
GA FU4RL
UT WOS:000423840200003
PM 29141571
OA Green Published
DA 2025-06-11
ER

PT J
AU Sardu, C
   Santulli, G
   Santamaria, M
   Barbieri, M
   Sacra, C
   Paolisso, P
   D'Amico, F
   Testa, N
   Caporaso, I
   Paolisso, G
   Maifella, R
   Rizzo, MR
AF Sardu, Celestino
   Santulli, Gaetano
   Santamaria, Matteo
   Barbieri, Michelangela
   Sacra, Cosimo
   Paolisso, Pasquale
   D'Amico, Fabio
   Testa, Nicola
   Caporaso, Igor
   Paolisso, Giuseppe
   Maifella, Raffaele
   Rizzo, Maria Rosaria
TI Effects of Alpha Lipoic Acid on Multiple Cytokines and Biomarkers and
   Recurrence of Atrial Fibrillation Within 1 Year of Catheter Ablation
SO AMERICAN JOURNAL OF CARDIOLOGY
LA English
DT Article
ID METABOLIC SYNDROME; INFLAMMATION; PERPETUATION; DISEASE; STRESS
AB Catheter ablation (CA) is a procedure commonly used to restore sinus rhythm in patients with atrial fibrillation (AF). However, AF recurrence after CA remains a relevant clinical issue. We tested the effects of an oral antioxidant treatment (alpha lipoic acid [ALA]) on AF recurrence post-CA. Patients with paroxysmal AF have been enrolled in a randomized, prospective, double-blind, controlled placebo trial. After CA, patients have been randomly assigned to receive ALA oral supplementation (ALA group) or placebo (control group) and evaluated at baseline and after a 12-month follow-up: 73 patients completed the 12-month follow-up (ALA: 33 and control: 40). No significant difference has been detected between the 2 groups at baseline. Strikingly, 1 year after CA, ALA therapy significantly reduced serum markers of inflammation. However, there was no significant difference in AF recurrence events at follow-up comparing ALA with placebo group. Multivariate analysis revealed that the only independent prognostic risk factor for AF recurrence after CA is age. In conclusion, ALA therapy reduces serum levels of common markers of inflammation in ablated patients. Nevertheless, ALA does not prevent AF recurrence after an ablative treatment. (C) 2017 Elsevier Inc. All rights reserved.
C1 [Sardu, Celestino; Barbieri, Michelangela; Paolisso, Pasquale; Maifella, Raffaele; Rizzo, Maria Rosaria] Univ Naples 2, Dept Med Surg Neurol Metab & Aging Sci, Naples, Italy.
   [Sardu, Celestino; Santamaria, Matteo; Sacra, Cosimo; D'Amico, Fabio; Testa, Nicola; Caporaso, Igor; Paolisso, Giuseppe] John Paul II Res Fdn, Arrhythmias & Electrophysiol Dept, Campobasso, Italy.
   [Santulli, Gaetano] Univ Naples Federico II, Dept Adv Biomed Sci, Naples, Italy.
   [Santulli, Gaetano] Columbia Univ, Med Ctr, New York Presbyterian Hosp, New York, NY 10027 USA.
C3 Universita della Campania Vanvitelli; University of Naples Federico II;
   NewYork-Presbyterian Hospital; Columbia University
RP Santulli, G (corresponding author), Univ Naples Federico II, Dept Adv Biomed Sci, Naples, Italy.; Santulli, G (corresponding author), Columbia Univ, Med Ctr, New York Presbyterian Hosp, New York, NY 10027 USA.
EM gsantulli001@gmail.com
RI Santamaria, Matteo/U-4066-2019; Sardu, Celestino/AAA-7451-2019;
   paolisso, giuseppe/AAP-8516-2020; Rizzo, Maria Rosaria/AHH-3649-2022;
   Marfella, Raffaele/AAH-2595-2019; Sacra, Cosimo/AAS-9085-2020; Santulli,
   Gaetano/I-9203-2016; Paolisso, Pasquale/AAB-5271-2020; Barbieri,
   Michelangela/K-2192-2016; Testa, Nicola/J-9173-2016
OI Sacra, Cosimo/0000-0003-4684-2521; Barbieri,
   Michelangela/0000-0002-9223-5792; Paolisso,
   Pasquale/0000-0002-7017-778X; /0000-0001-7231-375X; Testa,
   Nicola/0000-0003-1329-5031; Sardu, Celestino/0000-0001-5099-3790; Rizzo,
   Maria Rosaria/0000-0002-1023-4260; marfella,
   raffaele/0000-0003-3960-9270; Santamaria, Matteo/0000-0003-1000-0592
FU National Institutes of Health [K99/R00 DK107895]
FX Dr. Santulli is supported by the grant K99/R00 DK107895 from the
   National Institutes of Health.
CR [Anonymous], 2014, J AM COLL CARDIOL
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NR 30
TC 58
Z9 58
U1 0
U2 5
PU EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
PI BRIDGEWATER
PA 685 ROUTE 202-206 STE 3, BRIDGEWATER, NJ 08807 USA
SN 0002-9149
EI 1879-1913
J9 AM J CARDIOL
JI Am. J. Cardiol.
PD MAY 1
PY 2017
VL 119
IS 9
BP 1382
EP 1386
DI 10.1016/j.amjcard.2017.01.040
PG 5
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA EU5FA
UT WOS:000401055800015
PM 28258730
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Shukla, KK
   Chambial, S
   Dwivedi, S
   Misra, S
   Sharma, P
AF Shukla, K. K.
   Chambial, S.
   Dwivedi, S.
   Misra, S.
   Sharma, P.
TI Recent scenario of obesity and male fertility
SO ANDROLOGY
LA English
DT Review
DE lifestyle; male infertility; obesity; sleep disorders; sperm
   dysfunctions
ID BODY-MASS INDEX; OXYGEN SPECIES PRODUCTION; BLOOD-BRAIN-BARRIER; LEPTIN
   RECEPTOR; SEMEN QUALITY; REPRODUCTIVE HORMONES; ERECTILE DYSFUNCTION;
   METABOLIC SYNDROME; OXIDATIVE STRESS; MALE-INFERTILITY
AB The aim of this review was to provide current scenario linking obesity and male fertility. Obesity has been linked to male fertility because of lifestyle changes, internal hormonal environment alterations, and sperm genetic factors. A few studies assessing the impact of obesity on sperm genetic factor have been published, but they did not lead to a strong consensus. Our objective was to explore further the relationship between sperm genetic factor and obesity. There are emerging facts that obesity negatively affects male reproductive potential not only by reducing sperm quality, but in particular it alters the physical and molecular structure of germ cells in the testes and ultimately affects the maturity and function of sperm cells. Inhibition of microRNA in the male pronucleus of fertilized zygotes produces offspring of phenotypes of variable severity depending on miRNAs ratios. Hence, these RNAs have a role in the oocyte development during fertilization and in embryo development, fetal survival, and offspring phenotype. It has been reported that the miRNA profile is altered in spermatozoa of obese males, however, the impact of these changes in fertilization and embryo health remains as yet not known.
C1 [Shukla, K. K.; Chambial, S.; Dwivedi, S.; Sharma, P.] All India Inst Med Sci, Dept Biochem, Jodhpur 342005, Rajasthan, India.
   [Misra, S.] All India Inst Med Sci, Dept Surg Oncol, Jodhpur 342005, Rajasthan, India.
C3 All India Institute of Medical Sciences (AIIMS) Jodhpur; All India
   Institute of Medical Sciences (AIIMS) Jodhpur
RP Sharma, P (corresponding author), All India Inst Med Sci, Dept Biochem, Jodhpur 342005, Rajasthan, India.
EM praveensharma55@gmail.com
RI Sharma, Shailja/ABA-5210-2021; Sharma, Praveen/AAR-7750-2021; Shukla,
   Kamla/AAO-1256-2020; Dwivedi, Shailendra/H-9335-2019
OI Shukla, Kamla Kant/0000-0001-6086-2938; Dwivedi,
   Shailendra/0000-0003-2781-1009; Sharma, Praveen/0000-0002-8324-737X;
   Shukla, Kaushal K/0000-0002-8756-6474
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NR 134
TC 43
Z9 46
U1 1
U2 24
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2047-2919
EI 2047-2927
J9 ANDROLOGY-US
JI Andrology
PD NOV
PY 2014
VL 2
IS 6
BP 809
EP 818
DI 10.1111/andr.270
PG 10
WC Andrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA AS5SA
UT WOS:000344328700003
PM 25269421
OA Bronze
DA 2025-06-11
ER

PT J
AU Machado, MV
   Cortez-Pinto, H
AF Machado, Mariana Verdelho
   Cortez-Pinto, Helena
TI Non-alcoholic fatty liver disease: What the clinician needs to know
SO WORLD JOURNAL OF GASTROENTEROLOGY
LA English
DT Article
DE Non-alcoholic fatty liver disease; Metabolic syndrome; Insulin
   resistance; Epidemiology; Pathogenesis; Genetics; Diagnosis; Prognosis;
   Management
ID NECROSIS-FACTOR-ALPHA; MODERATE ALCOHOL-CONSUMPTION; PLACEBO-CONTROLLED
   TRIAL; LIFE-STYLE MODIFICATION; MANGANESE SUPEROXIDE-DISMUTASE; HEDGEHOG
   PATHWAY ACTIVATION; STELLATE CELL ACTIVATION; II RECEPTOR ANTAGONIST;
   INTESTINAL BACTERIAL OVERGROWTH; ENDOPLASMIC-RETICULUM STRESS
AB Non-alcoholic fatty liver disease (NAFLD) is the most frequent cause of liver disease in the Western world. Furthermore, it is increasing worldwide, paralleling the obesity pandemic. Though highly frequent, only about one fifth of affected subjects are at risk of developing the progressive form of the disease, non-alcoholic steatohepatitis with fibrosis. Even in the latter, liver disease is slowly progressive, though, since it is so prevalent, it is already the third cause of liver transplantation in the United States, and it is predicted to get to the top of the ranking in few years. Of relevance, fatty liver is also associated with increased overall mortality and particularly increased cardiovascular mortality. The literature and amount of published papers on NAFLD is increasing as fast as its prevalence, which makes it difficult to keep updated in this topic. This review aims to summarize the latest knowledge on NAFLD, in order to help clinicians understanding its pathogenesis and advances on diagnosis and treatment.
C1 [Machado, Mariana Verdelho; Cortez-Pinto, Helena] Hosp Univ Santa Maria, Dept Gastroenterol, Lab Nutr, P-1649035 Lisbon, Portugal.
C3 Universidade de Lisboa; Hospital Santa Maria
RP Cortez-Pinto, H (corresponding author), Hosp Univ Santa Maria, Dept Gastroenterol, Lab Nutr, P-1649035 Lisbon, Portugal.
EM hlcortezpinto@netcabo.pt
RI Cortez-Pinto, Helena/AAN-2712-2020
OI Cortez-Pinto, Helena/0000-0002-8537-8744
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NR 383
TC 148
Z9 177
U1 1
U2 27
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 7041 Koll Center Parkway, Suite 160, PLEASANTON, CA, UNITED STATES
SN 1007-9327
EI 2219-2840
J9 WORLD J GASTROENTERO
JI World J. Gastroenterol.
PD SEP 28
PY 2014
VL 20
IS 36
BP 12956
EP 12980
DI 10.3748/wjg.v20.i36.12956
PG 25
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA AR9GK
UT WOS:000343880900019
PM 25278691
OA Green Submitted, Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Mori, T
   Maeda, N
   Inoue, K
   Sekimoto, R
   Tsushima, Y
   Matsuda, K
   Yamaoka, M
   Suganami, T
   Nishizawa, H
   Ogawa, Y
   Funahashi, T
   Shimomura, I
AF Mori, Takuya
   Maeda, Norikazu
   Inoue, Kana
   Sekimoto, Ryohei
   Tsushima, Yu
   Matsuda, Keisuke
   Yamaoka, Masaya
   Suganami, Takayoshi
   Nishizawa, Hitoshi
   Ogawa, Yoshihiro
   Funahashi, Tohru
   Shimomura, Iichiro
TI A Novel Role for Adipose Ephrin-B1 in Inflammatory Response
SO PLOS ONE
LA English
DT Article
ID MONOCYTE CHEMOATTRACTANT PROTEIN-1; ENDOPLASMIC-RETICULUM STRESS;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; TYROSINE KINASE; EXPRESSION;
   OBESITY; EPH; IMPACT; TISSUE
AB Aims: Ephrin-B1 (EfnB1) was selected among genes of unknown function in adipocytes or adipose tissue and subjected to thorough analysis to understand its role in the development of obesity.
   Methods and Results: EfnB1 mRNA and protein levels were significantly decreased in adipose tissues of obese mice and such reduction was mainly observed in mature adipocytes. Exposure of 3T3-L1 adipocytes to tumor necrosis factor-alpha (TNF-alpha) and their culture with RAW264.7 cells reduced EFNB1 levels. Knockdown of adipose EFNB1 increased monocyte chemoattractant protein-1 (Mcp-1) mRNA level and augmented the TNF-alpha-mediated THP-1 monocyte adhesion to adipocytes. Adenovirus-mediated adipose EFNB1-overexpression significantly reduced the increase in Mcp-1 mRNA level induced by coculture of 3T3-L1 adipocytes with RAW264.7 cells. Monocyte adherent assay showed that adipose EfnB1-overexpression significantly decreased the increase of monocyte adhesion by coculture with RAW264.7 cells. TNF-alpha-induced activation of extracellular signal-regulated kinase 1/2 (ERK1/2) was reduced by EFNB1-overexpression.
   Conclusions: EFNB1 contributes to the suppression of adipose inflammatory response. In obesity, reduction of adipose EFNB1 may accelerate the vicious cycle involved in adipose tissue inflammation.
C1 [Mori, Takuya; Maeda, Norikazu; Inoue, Kana; Sekimoto, Ryohei; Tsushima, Yu; Matsuda, Keisuke; Yamaoka, Masaya; Nishizawa, Hitoshi; Funahashi, Tohru; Shimomura, Iichiro] Osaka Univ, Dept Metab Med, Grad Sch Med, Suita, Osaka, Japan.
   [Suganami, Takayoshi] Tokyo Med & Dent Univ, Dept Organ Network, Grad Sch Med & Dent Sci, Tokyo, Japan.
   [Suganami, Takayoshi; Ogawa, Yoshihiro] Tokyo Med & Dent Univ, Dept Metab, Grad Sch Med & Dent Sci, Tokyo, Japan.
   [Ogawa, Yoshihiro] Tokyo Med & Dent Univ, Dept Mol Endocrinol, Grad Sch Med & Dent Sci, Tokyo, Japan.
   [Funahashi, Tohru] Osaka Univ, Dept Metab, Grad Sch Med, Suita, Osaka, Japan.
   [Funahashi, Tohru] Osaka Univ, Dept Atherosclerosis, Grad Sch Med, Suita, Osaka, Japan.
C3 The University of Osaka; Institute of Science Tokyo; Tokyo Medical &
   Dental University (TMDU); Institute of Science Tokyo; Tokyo Medical &
   Dental University (TMDU); Institute of Science Tokyo; Tokyo Medical &
   Dental University (TMDU); The University of Osaka; The University of
   Osaka
RP Maeda, N (corresponding author), Osaka Univ, Dept Metab Med, Grad Sch Med, Suita, Osaka, Japan.
EM norikazu_maeda@endmet.med.osaka-u.ac.jp
RI SUGANAMI, Takayoshi/A-9475-2016; Maeda, Norikazu/LZI-4561-2025
OI Suganami, Takayoshi/0000-0002-1918-0465; Ogawa,
   Yoshihiro/0000-0002-0834-2836
FU Takeda Science Foundation;  [22590979];  [24390238];  [22126008];
   Grants-in-Aid for Scientific Research [25670439, 21117007] Funding
   Source: KAKEN
FX This work was supported in part by a Grants-in-Aid for Scientific
   Research (C) no. 22590979 (to NM), a Grants-in-Aid for Scientific
   Research (B) no. 24390238 (to IS), a Grants-in-Aid for Scientific
   Research on Innovative Areas no. 22126008 (to TF), and Takeda Science
   Foundation (to NM). The funders had no role in study design, data
   collection and analysis, decision to publish, or preparation of the
   manuscript.
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NR 37
TC 16
Z9 18
U1 0
U2 8
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD OCT 1
PY 2013
VL 8
IS 10
AR e76199
DI 10.1371/journal.pone.0076199
PG 9
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 231OR
UT WOS:000325427100047
PM 24098442
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT S
AU Samad, F
   Badeanlou, L
   Shah, C
   Yang, G
AF Samad, Fahumiya
   Badeanlou, Leylla
   Shah, Charmi
   Yang, Guang
BE Cowart, LA
TI ADIPOSE TISSUE AND CERAMIDE BIOSYNTHESIS IN THE PATHOGENESIS OF OBESITY
SO SPHINGOLIPIDS AND METABOLIC DISEASE
SE Advances in Experimental Medicine and Biology
LA English
DT Article; Book Chapter
ID PLASMINOGEN-ACTIVATOR INHIBITOR-1; LOW-DENSITY-LIPOPROTEIN;
   NECROSIS-FACTOR-ALPHA; INDUCED INSULIN-RESISTANCE; PROTEIN-KINASE-B;
   PLASMA SPHINGOLIPID METABOLISM; PLECKSTRIN HOMOLOGY DOMAIN;
   CELL-PERMEABLE CERAMIDE; SPHINGOSINE 1-PHOSPHATE; OXIDATIVE STRESS
AB Although obesity is a complex metabolic disorder often associated with insulin resistance, hyperinsulinemia and Type 2 diabetes, as well as with accelerated atherosclerosis, the molecular changes in obesity that promote these disorders are not completely understood. Several mechanisms have been proposed to explain how increased adipose tissue mass affects whole body insulin resistance and cardiovascular risk. One theory is that increased adipose derived inflammatory cytokines induces a chronic inflammatory state that not only increases cardiovascular risk, but also antagonizes insulin signaling and mitochondrial function and thereby impair glucose hemostasis. Another suggests that lipid accumulation in nonadipose tissues not suited for fat storage leads to the buildup of bioactive lipids that inhibit insulin signaling and metabolism. Recent evidence demonstrates that sphingolipid metabolism is dysregulated in obesity and specific sphingolipids may provide a common pathway that link excess nutrients and inflammation to increased metabolic and cardiovascular risk. This chapter will focus primarily on the expression and regulation of adipose and plasma ceramide biosynthesis in obesity and, its potential contribution to the pathogenesis of obesity and the metabolic syndrome.
C1 [Samad, Fahumiya; Badeanlou, Leylla; Shah, Charmi; Yang, Guang] Torrey Pines Inst Mol Studies, San Diego, CA USA.
C3 Torrey Pines Institute for Molecular Studies
RP Samad, F (corresponding author), Torrey Pines Inst Mol Studies, San Diego, CA USA.
EM fsamad@tpims.org
OI Samad, Fahumiya/0000-0001-7395-8605
FU NHLBI NIH HHS [R01HL071146] Funding Source: Medline
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NR 161
TC 45
Z9 50
U1 1
U2 11
PU SPRINGER-VERLAG BERLIN
PI BERLIN
PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY
SN 0065-2598
EI 2214-8019
BN 978-1-4614-0649-5
J9 ADV EXP MED BIOL
JI Adv.Exp.Med.Biol.
PY 2011
VL 721
BP 67
EP 86
D2 10.1007/978-1-4614-0650-1
PG 20
WC Biology; Medicine, Research & Experimental
WE Book Citation Index – Science (BKCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics; Research & Experimental
   Medicine
GA BWF42
UT WOS:000293800300005
PM 21910083
DA 2025-06-11
ER

PT J
AU Derosa, G
   D'Angelo, A
   Salvadeo, SAT
   Ferrari, I
   Fogari, E
   Gravina, A
   Mereu, R
   Palumbo, I
   Maffioli, P
   Randazzo, S
   Cicero, AFG
AF Derosa, G.
   D'Angelo, A.
   Salvadeo, S. A. T.
   Ferrari, I.
   Fogari, E.
   Gravina, A.
   Mereu, R.
   Palumbo, I.
   Maffioli, P.
   Randazzo, S.
   Cicero, A. F. G.
TI Oral Glucose Tolerance Test Effects on Endothelial Inflammation Markers
   in Healthy Subjects and Diabetic Patients
SO HORMONE AND METABOLIC RESEARCH
LA English
DT Article
DE type 2 diabetes mellitus; soluble adhesion molecules; vessels
   dysfunction; cardiovascular risk
ID INTERCELLULAR-ADHESION MOLECULE-1; FACTOR-KAPPA-B;
   CARDIOVASCULAR-DISEASE; OXIDATIVE STRESS; METABOLIC SYNDROME;
   MONONUCLEAR-CELLS; DOUBLE-BLIND; E-SELECTIN; HYPERGLYCEMIA; GENERATION
AB The aim of this study was to evaluate the effect of an oral glucose tolerance test (OGTT) on the level of endothelial dysfunction and vascular inflammation markers in healthy subjects (H) and diabetic overweight patients (D). We enrolled 256 healthy subjects and 274 type 2 diabetic patients. We evaluated blood glucose (BG), soluble intercellular adhesion molecule-1 (sICAM-1), interleukin-6 (IL-6), high-sensitivity C reactive protein (hsCRP), soluble vascular cell adhesion molecule-1 (sVCAM-1), soluble E-selectin (sE-selectin), and tumor necrosis factor-alpha (TNF-alpha) at baseline and after OGTT. We observed that BG, sICAM-1, IL-6, hs-CRP, sVCAM-1, sE-selectin, and TNF-alpha values were higher in D group than in H group. In a large sample of adult healthy subjects and type 2 diabetics we observed that both answer to an OGTT with a significant increase in biomarkers of systemic low-grade inflammation and endothelial dysfunction such as hsCRP, IL-6, TNF-alpha, sICAM-1, sVCAM-1, and sE-selectin. Type 2 diabetics experienced, however, a more significant increase in TNF-alpha, and sE-selectin.
C1 [Derosa, G.] Univ Pavia, Dept Internal Med & Therapeut, Fdn IRCCS Policlin S Matteo, I-27100 Pavia, Italy.
   Univ Bologna, G Descovich Atherosclerosis Study Ctr, D Campanacci Clin Med & Appl Biotechnol Dept, Bologna, Italy.
C3 University of Pavia; IRCCS Fondazione San Matteo; University of Bologna
RP Derosa, G (corresponding author), Univ Pavia, Dept Internal Med & Therapeut, Fdn IRCCS Policlin S Matteo, Ple C Golgi 2, I-27100 Pavia, Italy.
EM giuseppe.derosa@unipv.it
RI Cicero, Arrigo/H-8244-2019; Derosa, Giuseppe/H-8571-2019; Maffioli,
   Pamela/E-9753-2012; Derosa, Giuseppe/F-2615-2012
OI Fogari, Elena/0000-0002-9446-7546; Cicero, Arrigo Francesco
   Giuseppe/0000-0002-4367-3884; Maffioli, Pamela/0000-0002-4285-6507;
   Derosa, Giuseppe/0000-0003-3573-4760
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NR 39
TC 36
Z9 40
U1 0
U2 3
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0018-5043
EI 1439-4286
J9 HORM METAB RES
JI Horm. Metab. Res.
PD JAN
PY 2010
VL 42
IS 1
BP 8
EP 13
DI 10.1055/s-0029-1237728
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 548AW
UT WOS:000273932200002
PM 19735057
DA 2025-06-11
ER

PT J
AU Verhulst, S
   Holveck, MJ
   Riebel, K
AF Verhulst, Simon
   Holveck, Marie-Jeanne
   Riebel, Katharina
TI Long-term effects of manipulated natal brood size on metabolic rate in
   zebra finches
SO BIOLOGY LETTERS
LA English
DT Article
DE metabolic programming; metabolic syndrome; brood size manipulation;
   developmental stress; Taeniopygia guttata
ID SEX-RATIO; REPRODUCTION; GROWTH; COSTS; FETAL
AB Long-term effects of developmental conditions on health, longevity and other fitness components in humans are drawing increasing attention. In evolutionary ecology, such effects are of similar importance because of their role in the trade-off between quantity and quality of offspring. The central role of energy consumption is well documented for some long-term health effects in humans (e.g. obesity), but little is known of the long-term effects of rearing conditions on energy requirements later in life. We manipulated the rearing conditions in zebra finches (Taeniopygia guttata) using brood size manipulation and cross-fostering. It has previously been shown in this species that being reared in a large brood has negative fitness consequences, and that such effects are stronger in daughters than in sons. We show that, independent of mass, standard metabolic rate of 1-year-old birds was higher when they had been reared in a large brood, and this is to our knowledge the first demonstration of such an effect. Furthermore, the brood size effect was stronger in daughters than in sons. This suggests that metabolic efficiency may play a role in mediating the long-term fitness consequences of rearing conditions.
C1 Univ Groningen, NL-9750 AA Haren, Netherlands.
   Leiden Univ, Inst Biol, NL-2300 RA Leiden, Netherlands.
C3 University of Groningen; Leiden University; Leiden University - Excl
   LUMC
RP Verhulst, S (corresponding author), Univ Groningen, POB 14, NL-9750 AA Haren, Netherlands.
EM s.verhulst@rug.nl
RI Riebel, Katharina/AAC-7401-2021; Verhulst, Simon/S-3404-2019; Riebel,
   Katharina/F-5441-2010; Holveck, Marie-Jeanne/D-4004-2016
OI Verhulst, Simon/0000-0002-1143-6868; Riebel,
   Katharina/0000-0003-2373-8510; Holveck, Marie-Jeanne/0000-0002-6229-6367
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NR 22
TC 99
Z9 111
U1 0
U2 46
PU ROYAL SOC
PI LONDON
PA 6-9 CARLTON HOUSE TERRACE, LONDON SW1Y 5AG, ENGLAND
SN 1744-9561
EI 1744-957X
J9 BIOL LETTERS
JI Biol. Lett.
PD SEP 22
PY 2006
VL 2
IS 3
BP 478
EP 480
DI 10.1098/rsbl.2006.0496
PG 3
WC Biology; Ecology; Evolutionary Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics; Environmental Sciences &
   Ecology; Evolutionary Biology
GA 103CN
UT WOS:000241863400043
PM 17148435
OA Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Bartke, A
AF Bartke, Andrzej
TI Healthspan and longevity can be extended by suppression of growth
   hormone signaling
SO MAMMALIAN GENOME
LA English
DT Review
ID LIFE-SPAN EXTENSION; AMES DWARF MICE; INCREASED INSULIN SENSITIVITY;
   CALORIC RESTRICTION; ADIPONECTIN LEVELS; GLUCOSE-TOLERANCE; SNELL DWARF;
   NONAGENARIAN SIBLINGS; POLYMORPHIC VARIANTS; METABOLIC SYNDROME
AB Average and maximal lifespan are important biological characteristics of every species, but can be modified by mutations and by a variety of genetic, dietary, environmental, and pharmacological interventions. Mutations or disruption of genes required for biosynthesis or action of growth hormone (GH) produce remarkable extension of longevity in laboratory mice. Importantly, the long-lived GH-related mutants exhibit many symptoms of delayed and/or slower aging, including preservation of physical and cognitive functions and resistance to stress and age-related disease. These characteristics could be collectively described as "healthy aging" or extension of the healthspan. Extension of both the healthspan and lifespan in GH-deficient and GH-resistant mice appears to be due to multiple interrelated mechanisms. Some of these mechanisms have been linked to healthy aging and genetic predisposition to extended longevity in humans. Enhanced insulin sensitivity combined with reduced insulin levels, reduced adipose tissue, central nervous system inflammation, and increased levels of adiponectin represent such mechanisms. Further progress in elucidation of mechanisms that link reduced GH action to delayed and healthy aging should identify targets for lifestyle and pharmacological interventions that could benefit individuals as well as society.
C1 [Bartke, Andrzej] Southern Illinois Sch Med, Dept Internal Med, Springfield, IL 62702 USA.
RP Bartke, A (corresponding author), Southern Illinois Sch Med, Dept Internal Med, Springfield, IL 62702 USA.
EM abartke@siumed.edu
RI Bartke, Andzej/D-6640-2017
FU NIH [P01AG031736, R01AG019899]
FX Work described in this article was supported by NIH P01AG031736 and
   R01AG019899. We thank Dr. O. Arum, A. Spong, and other members of our
   laboratory who were importantly involved in various stages of this
   research and we apologize to those whose work pertinent to the discussed
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NR 128
TC 24
Z9 27
U1 0
U2 12
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0938-8990
EI 1432-1777
J9 MAMM GENOME
JI Mamm. Genome
PD AUG
PY 2016
VL 27
IS 7-8
SI SI
BP 289
EP 299
DI 10.1007/s00335-016-9621-3
PG 11
WC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
   Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
   Genetics & Heredity
GA DQ8XC
UT WOS:000379494000004
PM 26909495
OA Green Accepted
DA 2025-06-11
ER

PT J
AU DeFronzo, RA
   Ferrannini, E
   Groop, L
   Henry, RR
   Herman, WH
   Holst, JJ
   Hu, FB
   Kahn, CR
   Raz, I
   Shulman, GI
   Simonson, DC
   Testa, MA
   Weiss, R
AF DeFronzo, Ralph A.
   Ferrannini, Ele
   Groop, Leif
   Henry, Robert R.
   Herman, William H.
   Holst, Jens Juul
   Hu, Frank B.
   Kahn, C. Ronald
   Raz, Itamar
   Shulman, Gerald I.
   Simonson, Donald C.
   Testa, Marcia A.
   Weiss, Ram
TI Type 2 diabetes mellitus
SO NATURE REVIEWS DISEASE PRIMERS
LA English
DT Article
ID BETA-CELL FUNCTION; IMPAIRED GLUCOSE-TOLERANCE; HEPATIC
   INSULIN-RESISTANCE; ENDOPLASMIC-RETICULUM STRESS; LIFE-STYLE
   INTERVENTIONS; QUALITY-OF-LIFE; DIPEPTIDYL PEPTIDASE-4 INHIBITORS; IRS-1
   SERINE PHOSPHORYLATION; ADIPOSE-TISSUE INFLAMMATION; CARDIOVASCULAR
   RISK-FACTORS
AB Type 2 diabetes mellitus (T2DM) is an expanding global health problem, closely linked to the epidemic of obesity. Individuals with T2DM are at high risk for both microvascular complications (including retinopathy, nephropathy and neuropathy) and macrovascular complications (such as cardiovascular comorbidities), owing to hyperglycaemia and individual components of the insulin resistance (metabolic) syndrome. Environmental factors (for example, obesity, an unhealthy diet and physical inactivity) and genetic factors contribute to the multiple pathophysiological disturbances that are responsible for impaired glucose homeostasis in T2DM. Insulin resistance and impaired insulin secretion remain the core defects in T2DM, but at least six other pathophysiological abnormalities contribute to the dysregulation of glucose metabolism. The multiple pathogenetic disturbances present in T2DM dictate that multiple antidiabetic agents, used in combination, will be required to maintain normoglycaemia. The treatment must not only be effective and safe but also improve the quality of life. Several novel medications are in development, but the greatest need is for agents that enhance insulin sensitivity, halt the progressive pancreatic beta-cell failure that is characteristic of T2DM and prevent or reverse the microvascular complications. For an illustrated summary of this Primer,
C1 [DeFronzo, Ralph A.] Univ Texas Hlth Sci Ctr, South Texas Vet Hlth Care Syst, Dept Med, Diabet Div, 701 S Zarzamoro, San Antonio, TX 78207 USA.
   [DeFronzo, Ralph A.] Texas Diabet Inst, San Antonio, TX 78207 USA.
   [Ferrannini, Ele] CNR Inst Clin Physiol, Pisa, Italy.
   [Groop, Leif] Lund Univ, Ctr Diabet, Dept Clin Sci Malmoe Diabet & Endocrinol, Lund, Sweden.
   [Henry, Robert R.] Univ Calif San Diego, VA San Diego Healthcare Syst, Ctr Metab Res, Sect Diabet Endocrinol & Metab, San Diego, CA USA.
   [Herman, William H.] Univ Michigan, Ann Arbor, MI USA.
   [Holst, Jens Juul] Univ Copenhagen, Copenhagen, Denmark.
   [Hu, Frank B.] Harvard Med Sch, Brigham & Womens Hosp, Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA.
   [Hu, Frank B.] Harvard Med Sch, Brigham & Womens Hosp, Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA.
   [Hu, Frank B.] Harvard Med Sch, Brigham & Womens Hosp, Channing Div Network Med, Boston, MA USA.
   [Kahn, C. Ronald] Harvard Med Sch, Boston, MA USA.
   [Kahn, C. Ronald] Joslin Diabet Ctr, Boston, MA USA.
   [Raz, Itamar] Hadassah Hebrew Univ Hosp, Div Internal Med, Diabet Unit, Jerusalem, Israel.
   [Shulman, Gerald I.] Yale Univ, Sch Med, Howard Hughes Med Inst, New Haven, CT USA.
   [Shulman, Gerald I.] Yale Univ, Sch Med, Dept Internal Med, New Haven, CT USA.
   [Shulman, Gerald I.] Yale Univ, Sch Med, Dept Cellular & Mol Physiol, New Haven, CT USA.
   [Simonson, Donald C.] Harvard Med Sch, Brigham & Womens Hosp, Div Endocrinol Diabet & Hypertens, Boston, MA USA.
   [Testa, Marcia A.] Harvard TH Chan Sch Publ Hlth, Dept Biostat, Boston, MA USA.
   [Weiss, Ram] Hebrew Univ Jerusalem, Braun Sch Publ Hlth, Dept Human Metab & Nutr, Jerusalem, Israel.
C3 US Department of Veterans Affairs; Veterans Health Administration (VHA);
   Audie L. Murphy Memorial Veterans Hospital; University of Texas System;
   University of Texas Health Science Center at San Antonio; Consiglio
   Nazionale delle Ricerche (CNR); Istituto di Fisiologia Clinica
   (IFC-CNR); Lund University; University of California System; University
   of California San Diego; US Department of Veterans Affairs; Veterans
   Health Administration (VHA); VA San Diego Healthcare System; University
   of Michigan System; University of Michigan; University of Copenhagen;
   Harvard University; Harvard Medical School; Harvard T.H. Chan School of
   Public Health; Harvard University Medical Affiliates; Brigham & Women's
   Hospital; Harvard University; Harvard T.H. Chan School of Public Health;
   Harvard University Medical Affiliates; Brigham & Women's Hospital;
   Harvard Medical School; Harvard University; Harvard University Medical
   Affiliates; Brigham & Women's Hospital; Harvard Medical School; Harvard
   University; Harvard Medical School; Harvard University; Harvard
   University Medical Affiliates; Joslin Diabetes Center, Inc.; Hebrew
   University of Jerusalem; Hadassah University Hospital; Hadassah
   University Medical Center; Yale University; Howard Hughes Medical
   Institute; Yale University; Yale University; Harvard University; Harvard
   Medical School; Harvard University Medical Affiliates; Brigham & Women's
   Hospital; Harvard University; Harvard T.H. Chan School of Public Health;
   Hebrew University of Jerusalem
RP DeFronzo, RA (corresponding author), Univ Texas Hlth Sci Ctr, South Texas Vet Hlth Care Syst, Dept Med, Diabet Div, 701 S Zarzamoro, San Antonio, TX 78207 USA.
EM defronzo@uthscsa.edu
RI Ferrannini, Ele/B-8198-2013; Hu, Frank/C-1919-2013; Holst,
   Jens/AAA-8022-2022; Weiss, Ram/AAC-3964-2020; Kahn, Ronald/AAY-2435-2021
OI Shulman, Gerald/0000-0003-1529-5668; Holst, Jens
   Juul/0000-0001-6853-3805; Weiss, Ram/0000-0002-5663-8105
FU South Texas Veterans Healthcare System; National Institutes of Health
   [R01DK24092, DK58845, P30 DK46200, R01 DK-040936, R01 DK-049230, R24
   DK-085836, UL1 RR-045935, R01 DK-082659, R24 DK085610, P30 DK036836];
   Novo Nordisk Foundation for Basic Metabolic Research; University of
   Copenhagen; DVA-Merit Review grant; VA San Diego Healthcare System;
   National Institute for Diabetes and Digestive and Kidney Disease
   [P30DK092926]; Swedish Research Council [2010-3490, 2008-6589]; European
   Council [GA269045]; Italian Ministry of University Research [MIUR
   2010329EKE]; Patient-Centered Outcomes Research Institute (PCORI)
   Program Award [CE1304-6756]; NovoNordisk Foundation; National Institute
   of Diabetes and Digestive and Kidney Diseases [P30DK092926] Funding
   Source: NIH RePORTER
FX The authors acknowledge grants from: the South Texas Veterans Healthcare
   System to R.A.D.; the National Institutes of Health (grants R01DK24092
   to R.A.D.; DK58845 and P30 DK46200 to F.B.H.; R01 DK-040936, R01
   DK-049230, R24 DK-085836, UL1 RR-045935, R01 DK-082659 and R24 DK085610
   to G.I.S.; P30 DK036836 to C.R.K. Novo Nordisk Foundation for Basic
   Metabolic Research and the University of Copenhagen to G.I.S. and
   C.R.K.; DVA-Merit Review grant and VA San Diego Healthcare System to
   R.H.; National Institute for Diabetes and Digestive and Kidney Disease
   (grant P30DK092926) to W.H.; the Swedish Research Council (grants
   2010-3490 and 2008-6589) and European Council (grants GA269045) to L.G.;
   Italian Ministry of University & Research (MIUR 2010329EKE) to E.F.; the
   Patient-Centered Outcomes Research Institute (PCORI) Program Award
   (CE1304-6756) to D.C.S. and M.A.T.; NovoNordisk Foundation to the NNF
   Center for Basic Metabolic Research to J.H. W.H. acknowledges the
   Michigan Center for Diabetes Translational Research and I.R. thanks R.
   Sprung for editorial assistance.
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NR 321
TC 1094
Z9 1112
U1 28
U2 308
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2056-676X
J9 NAT REV DIS PRIMERS
JI Nat. Rev. Dis. Primers
PD JUL 23
PY 2015
VL 1
AR 15019
DI 10.1038/nrdp.2015.19
PG 22
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA DT2KZ
UT WOS:000381310500001
PM 27189025
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Fiorentini, D
   Zambonin, L
   Sega, FVD
   Hrelia, S
AF Fiorentini, Diana
   Zambonin, Laura
   Sega, Francesco Vieceli Dalla
   Hrelia, Silvana
TI Polyphenols as Modulators of Aquaporin Family in Health and Disease
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Review
ID SPINAL-CORD-INJURY; HYDROGEN-PEROXIDE; WATER CHANNELS; EPIGALLOCATECHIN
   GALLATE; APPLE POLYPHENOL; OXIDATIVE STRESS; GENE-EXPRESSION;
   DOWN-REGULATION; CEREBRAL EDEMA; BRAIN
AB Polyphenols are bioactive molecules widely distributed in fruits, vegetables, cereals, and beverages. Polyphenols in food sources are extensively studied for their role in the maintenance of human health and in the protection against development of chronic/degenerative diseases. Polyphenols act mainly as antioxidant molecules, protecting cell constituents against oxidative damage. The enormous number of polyphenolic compounds leads to huge different mechanisms of action not fully understood. Recently, some evidence is emerging about the role of polyphenols, such as curcumin, pinocembrin, resveratrol, and quercetin, in modulating the activity of some aquaporin (AQP) isoforms. AQPs are integral, small hydrophobic water channel proteins, extensively expressed in many organs and tissues, whose major function is to facilitate the transport of water or glycerol over cell plasma membranes. Here we summarize AQP physiological functions and report emerging evidence on the implication of these proteins in a number of pathophysiological processes. In particular, this review offers an overview about the role of AQPs in brain, eye, skin diseases, and metabolic syndrome, focusing on the ability of polyphenols to modulate AQP expression. This original analysis can contribute to elucidating some peculiar effects exerted by polyphenols and can lead to the development of an innovative potential preventive/therapeutic strategy.
C1 [Fiorentini, Diana; Zambonin, Laura; Sega, Francesco Vieceli Dalla] Univ Bologna, Dept Pharm & Biotechnol, Alma Mater Studiorum, I-40126 Bologna, Italy.
   [Hrelia, Silvana] Univ Bologna, Dept Life Qual Studies, Alma Mater Studiorum, I-47921 Rimini, Italy.
C3 University of Bologna; University of Bologna
RP Fiorentini, D (corresponding author), Univ Bologna, Dept Pharm & Biotechnol, Alma Mater Studiorum, Via Irnerio 48, I-40126 Bologna, Italy.
EM diana.fiorentini@unibo.it; silvana.hrelia@unibo.it
RI Zambonin, Laura/J-4883-2012; Vieceli Dalla Sega,
   Francesco/HCH-6857-2022; Hrelia, Silvana/P-2864-2015
OI ZAMBONIN, LAURA/0000-0001-7050-7825; Vieceli Dalla Sega,
   Francesco/0000-0003-3445-3983
FU "Fondazione del Monte di Bologna e Ravenna" (Italy)
FX Some data reported in this review have been obtained thanks to the
   financial support of "Fondazione del Monte di Bologna e Ravenna"
   (Italy).
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NR 76
TC 30
Z9 33
U1 0
U2 15
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PY 2015
VL 2015
AR 196914
DI 10.1155/2015/196914
PG 8
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA CP0DB
UT WOS:000359544900001
PM 26346093
OA hybrid, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Kim, J
   Di Vizio, D
   Kim, TK
   Kim, J
   Kim, M
   Pelton, K
   Clinton, SK
   Hai, T
   Hwang, D
   Solomon, KR
   Freeman, MR
AF Kim, Jayoung
   Di Vizio, Dolores
   Kim, Taek-Kyun
   Kim, Jonghwan
   Kim, Minjung
   Pelton, Kristine
   Clinton, Steven K.
   Hai, Tsonwin
   Hwang, Daehee
   Solomon, Keith R.
   Freeman, Michael R.
TI The Response of the Prostate to Circulating Cholesterol: Activating
   Transcription Factor 3 (ATF3) as a Prominent Node in a
   Cholesterol-Sensing Network
SO PLOS ONE
LA English
DT Article
ID STRESS-INDUCIBLE GENE; EPITHELIAL-CELLS; GROWTH-FACTOR; NEGATIVE
   REGULATOR; SYSTEMS BIOLOGY; CANCER; HYPERPLASIA; INFLAMMATION;
   EXPRESSION; RISK
AB Elevated circulating cholesterol is a systemic risk factor for cardiovascular disease and metabolic syndrome, however the manner in which the normal prostate responds to variations in cholesterol levels is poorly understood. In this study we addressed the molecular and cellular effects of elevated and suppressed levels of circulating cholesterol on the normal prostate. Integrated bioinformatic analysis was performed using DNA microarray data from two experimental formats: (1) ventral prostate from male mice with chronically elevated circulating cholesterol and (2) human prostate cells exposed acutely to cholesterol depletion. A cholesterol-sensitive gene expression network was constructed from these data and the transcription factor ATF3 was identified as a prominent node in the network. Validation experiments confirmed that elevated cholesterol reduced ATF3 expression and enhanced proliferation of prostate cells, while cholesterol depletion increased ATF3 levels and inhibited proliferation. Cholesterol reduction in vivo alleviated dense lymphomononuclear infiltrates in the periprostatic adipose tissue, which were closely associated with nerve tracts and blood vessels. These findings open new perspectives on the role of cholesterol in prostate health, and provide a novel role for ATF3, and associated proteins within a large signaling network, as a cholesterol-sensing mechanism.
C1 [Kim, Jayoung; Di Vizio, Dolores; Freeman, Michael R.] Cedars Sinai Med Ctr, Dept Surg, Div Canc Biol & Therapeut, Samuel Oschin Comprehens Canc Inst, Los Angeles, CA 90048 USA.
   [Kim, Jayoung; Di Vizio, Dolores; Freeman, Michael R.] Cedars Sinai Med Ctr, Dept Biomed Sci, Div Canc Biol & Therapeut, Samuel Oschin Comprehens Canc Inst, Los Angeles, CA 90048 USA.
   [Kim, Jayoung; Di Vizio, Dolores; Solomon, Keith R.; Freeman, Michael R.] Childrens Hosp, Urol Dis Res Ctr, Boston, MA 02115 USA.
   [Kim, Jayoung; Di Vizio, Dolores; Freeman, Michael R.] Harvard Univ, Sch Med, Dept Biol Chem & Mol Pharmacol, Boston, MA 02115 USA.
   [Kim, Jayoung; Di Vizio, Dolores; Freeman, Michael R.] Harvard Univ, Sch Med, Dept Surg, Boston, MA 02115 USA.
   [Kim, Taek-Kyun; Hwang, Daehee] Pohang Univ Sci & Technol, Dept Chem Engn, Pohang, South Korea.
   [Kim, Taek-Kyun; Hwang, Daehee] Pohang Univ Sci & Technol, Sch Interdisciplinary Biosci & Bioengn, Pohang, South Korea.
   [Kim, Jonghwan] Univ Texas Austin, Austin, TX 78712 USA.
   [Kim, Minjung] Univ S Florida, H Lee Moffitt Canc Ctr, Dept Mol Oncol Dept, Tampa, FL 33682 USA.
   [Pelton, Kristine; Solomon, Keith R.] Harvard Univ, Dept Orthopaed Surg, Sch Med, Childrens Hosp Boston, Boston, MA USA.
   [Clinton, Steven K.] Ohio State Univ, Coll Med, Columbus, OH 43210 USA.
   [Hai, Tsonwin] Ohio State Univ, Dept Mol & Cellular Biochem, Columbus, OH 43210 USA.
C3 Cedars Sinai Medical Center; Cedars Sinai Medical Center; Harvard
   University; Harvard University Medical Affiliates; Boston Children's
   Hospital; Harvard University; Harvard Medical School; Harvard
   University; Harvard Medical School; Pohang University of Science &
   Technology (POSTECH); Pohang University of Science & Technology
   (POSTECH); University of Texas System; University of Texas Austin; State
   University System of Florida; University of South Florida; H Lee Moffitt
   Cancer Center & Research Institute; Harvard University; Harvard
   University Medical Affiliates; Boston Children's Hospital; Harvard
   Medical School; University System of Ohio; Ohio State University;
   University System of Ohio; Ohio State University
RP Kim, J (corresponding author), Cedars Sinai Med Ctr, Dept Surg, Div Canc Biol & Therapeut, Samuel Oschin Comprehens Canc Inst, Los Angeles, CA 90048 USA.
EM Jayoung.Kim@cshs.org; Jayoung.Kim@cshs.org; Michael.Freeman@cshs.org
RI Kim, Taekkyun/A-9810-2017; Hai, Tsonwin/E-3185-2011; Kim,
   Jonghwan/AAR-2815-2021
OI Kim, Jonghwan/0000-0002-9919-9843; Kim, Minjung/0000-0002-5682-6640
FU National Institutes of Health [R01 DK087806, R01 CA143777, P50 DK65298,
   R01 CA101046, NCI K99 CA131472]; Fishbein Family IC Research
   Foundation/Interstitial Cystitis Association (ICA); Pilot Research
   Program/ICA; New York Academy of Medicine; Children's Hospital Boston
   Faculty Development
FX This work was supported by the following funding sources: National
   Institutes of Health grants R01 DK087806, R01 CA143777 and P50 DK65298
   (to MRF); R01 CA101046 (to KRS); and NCI K99 CA131472 (to DDV); the
   Fishbein Family IC Research Foundation/Interstitial Cystitis Association
   (ICA), Pilot Research Program/ICA, New York Academy of Medicine, and
   Children's Hospital Boston Faculty Development (to Jayoung Kim). Jayoung
   Kim is an American Urological Association Foundation Research Scholar
   and a Harvard Medical School Eleanor and Miles Shore Scholar. The
   funders had no role in study design, data collection and analysis,
   decision to publish, or preparation of the manuscript.
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NR 56
TC 7
Z9 8
U1 0
U2 7
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JUL 2
PY 2012
VL 7
IS 7
AR e39448
DI 10.1371/journal.pone.0039448
PG 14
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 968GX
UT WOS:000305966500014
PM 22768301
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Sales, PF
   Nascimento, ALD
   Pinheiro, FC
   Alberto, AKM
   dos Santos, AVTDT
   Carvalho, HD
   de Souza, GC
   Carvalho, JCT
AF Sales, Priscila Faimann
   Nascimento, Aline Lopes do
   Pinheiro, Fernanda Cavalcante
   Alberto, Andressa Ketelem Meireles
   dos Santos, Abrahao Victor Tavares de Lima Teixeira
   Carvalho, Helison de Oliveira
   de Souza, Gisele Custodio
   Carvalho, Jose Carlos Tavares
TI Effect of the Association of Fixed Oils from Abelmoschus
   esculentus (L.) Moench, Euterpe oleracea Martius, Bixa
   orellana Linné and Chronic SM® on Atherogenic Dyslipidemia in Wistar
   Rats
SO MOLECULES
LA English
DT Article
DE hypercholesterolemia; atherosclerosis; vegetable oils
ID PROLIFERATOR-ACTIVATED RECEPTORS; TISSUE FACTOR EXPRESSION; FATTY-ACIDS;
   PPAR-ALPHA; METABOLIC SYNDROME; OXIDATIVE STRESS; SATURATED-FAT; ACAI;
   OKRA; SEED
AB Dyslipidemia presents high levels of serum cholesterol and is characterized as a risk factor for cardiovascular diseases, especially for the development of atherosclerosis. E. oleracea oil (OFEO), A. esculentus oil (OFAE), B. orellana oil (OFBO), and Chronic SM (R) granules (CHR) are rich in bioactive compounds with the potential to treat changes in lipid metabolism. This study investigated the effects of treatments with oils from A. esculentus, E. oleracea, B. orellana, and Chronic SM (R) on Cocos nucifera L. saturated-fat-induced dyslipidemia. The chromatographic profile showed the majority presence of unsaturated fatty acids in the tested oils. The quantification of tocotrienols and geranylgeraniol in OFBO and CHR was obtained. Treatments with OFEO, OFAE, OFBO, and CHR were able to significantly reduce glycemia, as well as hypertriglyceridemia, total cholesterol, and LDL-cholesterol, besides increasing HDL-cholesterol. The treatments inhibited the formation of atheromatous plaques in the vascular endothelium of the treated rats. The obtained results suggest that the OFEO, OFAE, OFBO, and CHR exhibit antidyslipidemic effects and antiatherogenic activity.
C1 [Sales, Priscila Faimann; Nascimento, Aline Lopes do; Pinheiro, Fernanda Cavalcante; Alberto, Andressa Ketelem Meireles; dos Santos, Abrahao Victor Tavares de Lima Teixeira; Carvalho, Helison de Oliveira; de Souza, Gisele Custodio; Carvalho, Jose Carlos Tavares] Univ Fed Amapa, Pharm Fac, Biol & Hlth Sci Dept, Lab Drugs Res, Rod JK Km 02, BR-68902280 Macapa, AP, Brazil.
   [Carvalho, Jose Carlos Tavares] Univ Fed Amapa, Univ Hosp, Rodovia Josmar Chaves Pinto, BR-68903419 Macapa, Brazil.
C3 Fundacao Universidade Federal do Amapa; Fundacao Universidade Federal do
   Amapa
RP Carvalho, JCT (corresponding author), Univ Fed Amapa, Pharm Fac, Biol & Hlth Sci Dept, Lab Drugs Res, Rod JK Km 02, BR-68902280 Macapa, AP, Brazil.; Carvalho, JCT (corresponding author), Univ Fed Amapa, Univ Hosp, Rodovia Josmar Chaves Pinto, BR-68903419 Macapa, Brazil.
EM pfaimann@gmail.com; ali.nascimento99@gmail.com;
   fernandacavalcante602@gmail.com; andressaketelem@gmail.com;
   abrahaolima28@gmail.com; helison.farma@gmail.com;
   gi.custodio.souza@gmail.com; farmacos@unifap.br
RI dos Santos, Abrahão/P-6008-2018; Carvalho, Jose Carlos/S-2427-2019;
   Custodio, GISELE/KPB-0767-2024; Carvalho, Helison/IQT-9898-2023
FU National Council for Scientific and Technological Development-CNPq
   [12/2020-765Proc.: 403587/2020-4]; Master's and Doctoral Program for
   Innovation-MAI/DAI
FX National Council for Scientific and Technological Development-CNPq No.
   12/2020-765Proc.: 403587/2020-4, Master's and Doctoral Program for
   Innovation-MAI/DAI.
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NR 107
TC 2
Z9 2
U1 0
U2 3
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 1420-3049
J9 MOLECULES
JI Molecules
PD SEP
PY 2023
VL 28
IS 18
AR 6689
DI 10.3390/molecules28186689
PG 20
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA T3BF4
UT WOS:001076762700001
PM 37764465
OA Green Submitted, gold, Green Published
DA 2025-06-11
ER

PT J
AU Umbro, I
   Baratta, F
   Angelico, F
   Del Ben, M
AF Umbro, Ilaria
   Baratta, Francesco
   Angelico, Francesco
   Del Ben, Maria
TI Nonalcoholic Fatty Liver Disease and the Kidney: A Review
SO BIOMEDICINES
LA English
DT Review
DE nonalcoholic fatty liver disease; liver fibrosis; chronic kidney
   disease; renal function; kidney
ID INSULIN-RESISTANCE; METABOLIC SYNDROME; ASSOCIATION; VIRUS; DIET
AB Nonalcoholic fatty liver disease (NAFLD) is associated with several extrahepatic manifestations such as cardiovascular disease and sleep apnea. Furthermore, NAFLD is reported to be associated with an increased risk of incident chronic kidney disease (CKD). Inflammation and oxidative stress are suggested to be the key factors involved in the inflammatory mechanisms and pathways linking NAFLD to CKD and are responsible for both the pathogenesis and the progression of CKD in NAFLD patients. This review aims to provide a more comprehensive overview of the association between CKD and NAFLD, also considering the effect of increasing severity of NAFLD. A PubMed search was conducted using the terms "non-alcoholic fatty liver disease AND kidney ". In total, 537 articles were retrieved in the last five years and 12 articles were included in the qualitative analysis. Our results showed that CKD developed more frequently in NAFLD patients compared to those without NAFLD. This association persisted after adjustment for traditional risk factors and according to the severity of NAFLD. Therefore, patients with NAFLD should be considered at high risk of CKD. Intensive multidisciplinary surveillance over time is needed, where hepatologists and nephrologists must act together for better and earlier treatment of NAFLD patients.
C1 [Umbro, Ilaria] Geramed Dialysis Ctr, I-00065 Rome, Italy.
   [Baratta, Francesco; Del Ben, Maria] Sapienza Univ Rome, Dept Clin Internal Anesthesiol & Cardiovasc Sci, I-00161 Rome, Italy.
   [Angelico, Francesco] Sapienza Univ Rome, Dept Publ Hlth & Infect Dis, I-00161 Rome, Italy.
C3 Sapienza University Rome; Sapienza University Rome
RP Umbro, I (corresponding author), Geramed Dialysis Ctr, I-00065 Rome, Italy.
EM ilaria.umbro@geramed.it; francesco.baratta@uniroma1.it;
   francesco.angelico@uniroma1.it; maria.delben@uniroma1.it
RI Del Ben, Maria/AAE-7603-2020; Angelico, Francesco/AAB-6585-2020
OI Umbro, Ilaria/0000-0001-8237-0766; Baratta,
   Francesco/0000-0003-1708-272X; DEL BEN, MARIA/0000-0003-1199-8454
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NR 58
TC 15
Z9 16
U1 0
U2 9
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2227-9059
J9 BIOMEDICINES
JI Biomedicines
PD OCT
PY 2021
VL 9
IS 10
AR 1370
DI 10.3390/biomedicines9101370
PG 11
WC Biochemistry & Molecular Biology; Medicine, Research & Experimental;
   Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Research & Experimental Medicine;
   Pharmacology & Pharmacy
GA WV3WE
UT WOS:000717169700001
PM 34680486
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Oliveira, FMS
   Tran, WH
   Lesser, DJ
   Bhatia, R
   Keens, TG
   Mittelman, SD
   Ward, SLD
   Khoo, MCK
AF Oliveira, Flavia M. S.
   Tran, Winston H.
   Lesser, Daniel J.
   Bhatia, Rajeev
   Keens, Thomas G.
   Mittelman, Steven D.
   Ward, Sally L. Davidson
   Khoo, Michael C. K.
TI Abnormalities in autonomic function in obese boys at-risk for insulin
   resistance and obstructive sleep apnea
SO PEDIATRIC RESEARCH
LA English
DT Article
ID OVERWEIGHT HISPANIC YOUTH; BETA-CELL FUNCTION; BAROREFLEX SENSITIVITY;
   BLOOD-PRESSURE; CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; HEART-RATE;
   CHILDREN; GLUCOSE; MECHANISMS
AB STUDY OBJECTIVES: Current evidence in adults suggests that, independent of obesity, obstructive sleep apnea (OSA) can lead to autonomic dysfunction and impaired glucose metabolism, but these relationships are less clear in children. The purpose of this study was to investigate the associations among OSA, glucose metabolism, and daytime autonomic function in obese pediatric subjects.
   METHODS: Twenty-three obese boys participated in: overnight polysomnography; a frequently sampled intravenous glucose tolerance test; and recordings of spontaneous cardiorespiratory data in both the supine (baseline) and standing (sympathetic stimulus) postures.
   RESULTS: Baseline systolic blood pressure and reactivity of low-frequency heart rate variability to postural stress correlated with insulin resistance, increased fasting glucose, and reduced beta-cell function, but not OSA severity. Baroreflex sensitivity reactivity was reduced with sleep fragmentation, but only for subjects with low insulin sensitivity and/or low first-phase insulin response to glucose.
   CONCLUSIONS: These findings suggest that vascular sympathetic activity impairment is more strongly affected by metabolic dysfunction than by OSA severity, while blunted vagal autonomic function associated with sleep fragmentation in OSA is enhanced when metabolic dysfunction is also present.
C1 [Oliveira, Flavia M. S.] Univ Brasilia, Dept Elect Engn, Brasilia, DF, Brazil.
   [Tran, Winston H.; Khoo, Michael C. K.] Univ Southern Calif, Dept Biomed Engn, Los Angeles, CA USA.
   [Lesser, Daniel J.; Bhatia, Rajeev; Keens, Thomas G.; Ward, Sally L. Davidson] Childrens Hosp Los Angeles, Div Pediat Pulmonol & Sleep Med, Los Angeles, CA 90027 USA.
   [Mittelman, Steven D.] Childrens Hosp Los Angeles, Diabet & Obes Program, Ctr Endocrinol Diabet & Metab, Los Angeles, CA 90027 USA.
C3 Universidade de Brasilia; University of Southern California; Children's
   Hospital Los Angeles; Children's Hospital Los Angeles
RP Oliveira, FMS (corresponding author), Univ Brasilia, Dept Elect Engn, Brasilia, DF, Brazil.
EM flavia@ene.unb.br
RI Bhatia, Rajeev/AAU-9341-2021; Oliveira, Flavia Maria/AAV-3779-2021
OI Oliveira, Flavia Maria/0000-0003-4894-9007
FU NIH [HL105210, HL090451, EB001978, RR00047]; USC Center for
   Transdisciplinary Research on Energetics and Cancer [TREC U54 CA 116848]
FX This work was supported in part by NIH Grants HL105210, HL090451,
   EB001978, RR00047, and the USC Center for Transdisciplinary Research on
   Energetics and Cancer (TREC U54 CA 116848). F.M.S. Oliveira also thanks
   the Fulbright/CAPES program.
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NR 45
TC 2
Z9 3
U1 0
U2 5
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0031-3998
EI 1530-0447
J9 PEDIATR RES
JI Pediatr. Res.
PD MAY
PY 2019
VL 85
IS 6
BP 790
EP 798
DI 10.1038/s41390-018-0226-2
PG 9
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA HW0YI
UT WOS:000466408300014
PM 30420708
OA Bronze, Green Accepted
DA 2025-06-11
ER

PT J
AU Gong, LL
   Li, GR
   Zhang, W
   Liu, H
   Lv, YL
   Han, FF
   Wan, ZR
   Shi, MB
   Liu, LH
AF Gong, Li-li
   Li, Guang-run
   Zhang, Wen
   Liu, He
   Lv, Ya-li
   Han, Fei-fei
   Wan, Zi-rui
   Shi, Ming-biao
   Liu, Li-hong
TI Akebia Saponin D Decreases Hepatic Steatosis through Autophagy
   Modulation
SO JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
LA English
DT Article
ID FATTY LIVER-DISEASE; DIPSACUS-ASPER WALL; ASPEROSAPONIN VI; FLUX;
   APOPTOSIS; STRESS
AB Nonalcoholic fatty liver disease (NAFLD) is considered to be a hepatic manifestation of the metabolic syndrome, and the incidence of NAFLD is increasing rapidly. However, appropriate drugs for treatment of NAFLD are lacking. This study aimed to elucidate the protective effects and mechanisms of Akebia saponin D (ASD) against NAFLD in ob/ob mice and Buffalo rat liver cells. ASD significantly decreased hepatic steatosis and hepatocyte apoptosis in ob/ob mice. ASD also significantly activated autophagic flux, as assessed by the decreased expression of light chain 3 (LC3)-II and P62 accumulation of autophagosomes. In Buffalo rat liver cells, ASD prevented oleic acid (OA)-induced lipid droplets and increased autophagic flux acting as increase the number of autolysosomes than autophagosomes in mTagRFP-mWasabi-LC3. ASD treatment also prevented OA-induced expression of LC3-II, P62, Beclin, and phospho-mammalian target of rapamycin. These effects were similar to those of cotreatment with rapamycin. ASD treatment could not prevent OA-increased, autophagy-related protein expression after treatment with chloroquine or small interfering RNA-mediated knockdown of atg7. These results suggest that ASD alleviates hepatic steatosis targeted at the fusion of autophagosomes to lysosomes, and autophagy modulation via ASD may offer a new strategy for treating NAFLD.
C1 [Gong, Li-li; Li, Guang-run; Zhang, Wen; Liu, He; Lv, Ya-li; Han, Fei-fei; Wan, Zi-rui; Shi, Ming-biao; Liu, Li-hong] Capital Med Univ, Beijing Chao Yang Hosp, 8 Gongren Tiyuchang Nanlu, Beijing 100020, Peoples R China.
C3 Capital Medical University
RP Liu, LH (corresponding author), Capital Med Univ, Beijing Chao Yang Hosp, 8 Gongren Tiyuchang Nanlu, Beijing 100020, Peoples R China.
EM hongllh@126.com
RI Han, Feifei/S-9552-2019; gong, lili/IWV-0048-2023
FU National Natural Science Foundation of China [81302822]; Beijing
   Municipal Administration of Hospitals' Youth Programme [QML20150302];
   Capital Medical University [15ZY02]
FX This research was supported by the National Natural Science Foundation
   of China [Grant 81302822], the Beijing Municipal Administration of
   Hospitals' Youth Programme [Grant QML20150302], and the Capital Medical
   University [Grant 15ZY02].
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NR 27
TC 33
Z9 36
U1 0
U2 21
PU AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3995 USA
SN 0022-3565
EI 1521-0103
J9 J PHARMACOL EXP THER
JI J. Pharmacol. Exp. Ther.
PD DEC 1
PY 2016
VL 359
IS 3
BP 392
EP 400
DI 10.1124/jpet.116.236562
PG 9
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA EE4WH
UT WOS:000389605800002
PM 27672081
DA 2025-06-11
ER

PT J
AU Kapoor, MP
   Ishihara, N
   Okubo, T
AF Kapoor, Mahendra P.
   Ishihara, Noriyuki
   Okubo, Tsutomu
TI Soluble dietary fibre partially hydrolysed guar gum markedly impacts on
   postprandial hyperglycaemia, hyperlipidaemia and incretins metabolic
   hormones over time in healthy and glucose intolerant subjects
SO JOURNAL OF FUNCTIONAL FOODS
LA English
DT Article
DE Partially hydrolysed guar gum; Hyperlipidaemia; Postprandial glycaemia;
   Incretins metabolic hormones
ID LOW-DENSITY-LIPOPROTEIN; C-REACTIVE PROTEIN; INSULIN-RESISTANCE;
   FUNCTIONAL FOODS; OXIDATIVE STRESS; GLYCEMIC INDEX; BLOOD-GLUCOSE;
   CHOLESTEROL; MANAGEMENT; SATIETY
AB Dietary fibre intakes have consistently been associated with reduced risk of diabetes and metabolic syndrome. We investigated in 12 healthy subjects if administration of dietary fibre partially hydrolysed guar gum (PHGG) induces beneficial impact on hyperglycaemia, hyperlipidaemia and incretins metabolic hormones. Administration of 6 g/PHGG with each meal for 12 months significantly lowered the postprandial plasma glucose (PG), reduced both the fasting and postprandial insulin (IRI) and triacylglycerol (TG) levels (p = 0.05). Low density lipoprotein (LDL) was lower, whereas high-density lipoprotein (HDL) level was significantly increased (p < 0.01). Plasma leptin, high-sensitive C-reactive protein (hs-CRP) and fasting glucagon like peptide (GLP-1) were also lowered. In fact, 3 out of 6 glucose intolerant subjects turned out to be normal glucose tolerant after only 3 months of PHGG supplementation. Therefore, this preliminary study revealed that inclusion of PHGG in diets potentially impact on metabolic health profiles by affecting circulating metabolites that are responsible for glycaemia, hyperinsulinaemia and hyperlipidaemia factors. (c) 2016 Elsevier Ltd. All rights reserved.
C1 [Kapoor, Mahendra P.; Ishihara, Noriyuki; Okubo, Tsutomu] Taiyo Kagaku Co Ltd, Div Nutr, 1-3 Takaramachi, Yokaichi, Mie 5100844, Japan.
C3 TAIYO KAGAKU CO., LTD.
RP Kapoor, MP (corresponding author), Taiyo Kagaku Co Ltd, Div Nutr, 1-3 Takaramachi, Yokaichi, Mie 5100844, Japan.
EM mkapoor@taiyokagaku.co.jp
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NR 54
TC 22
Z9 26
U1 2
U2 49
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1756-4646
EI 2214-9414
J9 J FUNCT FOODS
JI J. Funct. Food.
PD JUN
PY 2016
VL 24
BP 207
EP 220
DI 10.1016/j.jff.2016.04.008
PG 14
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA DP3BJ
UT WOS:000378367100021
DA 2025-06-11
ER

PT J
AU Lilios, G
   Apetroaei, MR
   Dantes, E
AF Lilios, G.
   Apetroaei, M. R.
   Dantes, E.
TI ENVIRONMENTAL FACTORS INFLUENCE ON HUMAN HEALTH-ALKALINE WATER USAGE
SO JOURNAL OF ENVIRONMENTAL PROTECTION AND ECOLOGY
LA English
DT Article
DE alkaline water; TNF-alpha; hs-CRP; cardiovascular risk; oxidative stress
ID C-REACTIVE PROTEIN; CARDIOVASCULAR MORTALITY; DRINKING-WATER; HARDNESS
AB Tumour necrosis factor (TNF-alpha) is a pro-inflammatory cytokine produced by a variety of cells. TNF-alpha binding to the receptor results in conformational changes of the receptor structure, the cascade leading to the activation of the transcription of other proteins involved in the induction of local and systemic pro-inflammatory effects. Twenty patients diagnosed with essential arterial hypertension and metabolic syndrome have been evaluated. We have examined the correlation between serum high-sensitivity C-reactive protein (hs-CRP), tumor necrosis factor (TNF-alpha) levels and the prognosis of the disease. The results were compared using the t-Student test, 0.05 (p < 0.05) being considered the minimum threshold of statistical significance. The results of hs-CRP (mg/l) and TNF-alpha (pg/ml) levels for patients in the test group are significantly increased in comparison to the control group values. We also studied the evolution of these biomarkers in patients from the test group after six months of drinking alkaline water (pH 9). High serum levels of TNF-alpha constitutes a marker for systemic inflammatory response, being involved in the occurrence of the insulin resistance mechanism, developing major cardiovascular events.
C1 [Apetroaei, M. R.] Naval Acad Mirceacel Batran, Fac Nav & Naval Management, 1 Fulgerului St, Constanta, Romania.
   [Lilios, G.; Dantes, E.] Ovidius Univ Constanta, Constanta, Romania.
C3 Mircea cel Batran Naval Academy; Ovidius University
RP Apetroaei, MR (corresponding author), Naval Acad Mirceacel Batran, Fac Nav & Naval Management, 1 Fulgerului St, Constanta, Romania.
EM mrapetroaei@yahoo.com
RI Apetroaei, Manuela/X-3430-2019
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NR 17
TC 1
Z9 1
U1 0
U2 10
PU SCIBULCOM LTD
PI SOFIA
PA PO BOX 249, 1113 SOFIA, BULGARIA
SN 1311-5065
J9 J ENVIRON PROT ECOL
JI J. Environ. Prot. Ecol.
PY 2015
VL 16
IS 4
BP 1612
EP 1619
PG 8
WC Environmental Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology
GA DB9UZ
UT WOS:000368864500045
DA 2025-06-11
ER

PT J
AU Kushner, RF
   Sorensen, KW
AF Kushner, Robert F.
   Sorensen, Kirsten Webb
TI Lifestyle medicine: the future of chronic disease management
SO CURRENT OPINION IN ENDOCRINOLOGY DIABETES AND OBESITY
LA English
DT Review
DE lifestyle medicine; prevention; risk factor reduction
ID CARDIOVASCULAR RISK-FACTORS; PROMOTE PHYSICAL-ACTIVITY; METABOLIC
   SYNDROME; HEALTH BEHAVIORS; ADULTS; INTERVENTIONS; DIET; CARE;
   ASSOCIATION; METAANALYSIS
AB Purpose of reviewLifestyle medicine is a new discipline that has recently emerged as a systematized approach for management of chronic disease. The practice of lifestyle medicine requires skills and competency in addressing multiple health risk behaviours and improving self-management. Targets include diet, physical activity, behaviour change, body weight control, treatment plan adherence, stress and coping, spirituality, mind body techniques, tobacco and substance abuse. This review focuses on the impact of a healthy lifestyle on chronic disease, the rarity of good health and the challenges of implementing a lifestyle medicine programme.Recent findingsUnhealthy lifestyle behaviours are at the root of the global burden of noncommunicable diseases and account for about 63% of all deaths. Over the past several years, there has been an increased interest in evaluating the benefit of adhering to low-risk lifestyle' behaviours and ideal cardiovascular health metrics'. Although a healthy lifestyle has repeatedly been shown to improve mortality, the population prevalence of healthy living remains low.SummaryLifestyle medicine presents a new and challenging approach to address the prevention and treatment of noncommunicable diseases, the most important and prevalent causes for increased morbidity and mortality worldwide.
C1 [Kushner, Robert F.] Northwestern Univ, Feinberg Sch Med, Chicago, IL 60611 USA.
   [Kushner, Robert F.; Sorensen, Kirsten Webb] Northwestern Med Fac Fdn, Ctr Lifestyle Med, Chicago, IL USA.
C3 Northwestern University; Feinberg School of Medicine
RP Kushner, RF (corresponding author), Northwestern Univ, Feinberg Sch Med, Northwestern Comprehens Ctr Obes, 750 North Lake Shore Dr,Rubloff 9-976, Chicago, IL 60611 USA.
EM rkushner@northwestern.edu
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NR 60
TC 87
Z9 95
U1 0
U2 62
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1752-296X
EI 1752-2978
J9 CURR OPIN ENDOCRINOL
JI Curr. Opin. Endocrinol. Diabetes Obes.
PD OCT
PY 2013
VL 20
IS 5
BP 389
EP 395
DI 10.1097/01.med.0000433056.76699.5d
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism
GA 247BG
UT WOS:000326587900004
PM 23974765
DA 2025-06-11
ER

PT J
AU Tsushima, Y
   Nishizawa, H
   Tochino, Y
   Nakatsuji, H
   Sekimoto, R
   Nagao, H
   Shirakura, T
   Kato, K
   Imaizumi, K
   Takahashi, H
   Tamura, M
   Maeda, N
   Funahashi, T
   Shimomura, I
AF Tsushima, Yu
   Nishizawa, Hitoshi
   Tochino, Yoshihiro
   Nakatsuji, Hideaki
   Sekimoto, Ryohei
   Nagao, Hirofumi
   Shirakura, Takashi
   Kato, Kenta
   Imaizumi, Keiichiro
   Takahashi, Hiroyuki
   Tamura, Mizuho
   Maeda, Norikazu
   Funahashi, Tohru
   Shimomura, Iichiro
TI Uric Acid Secretion from Adipose Tissue and Its Increase in Obesity
SO JOURNAL OF BIOLOGICAL CHEMISTRY
LA English
DT Article
ID VISCERAL FAT ACCUMULATION; XANTHINE-OXIDOREDUCTASE; METABOLIC SYNDROME;
   ENDOTHELIAL-CELLS; ADIPOCYTOKINE DYSREGULATION; INSULIN-RESISTANCE;
   OXIDATIVE STRESS; IN-VIVO; HYPOXIA; RAT
AB Obesity is often accompanied by hyperuricemia. However, purine metabolism in various tissues, especially regarding uric acid production, has not been fully elucidated. Here we report, using mouse models, that adipose tissue could produce and secrete uric acid through xanthine oxidoreductase (XOR) and that the production was enhanced in obesity. Plasma uric acid was elevated in obese mice and attenuated by administration of the XOR inhibitor febuxostat. Adipose tissue was one of major organs that had abundant expression and activities of XOR, and adipose tissues in obese mice had higher XOR activities than those in control mice. 3T3-L1 and mouse primary mature adipocytes produced and secreted uric acid into culture medium. The secretion was inhibited by febuxostat in a dose-dependent manner or by gene knockdown of XOR. Surgical ischemia in adipose tissue increased local uric acid production and secretion via XOR, with a subsequent increase in circulating uric acid levels. Uric acid secretion from whole adipose tissue was increased in obese mice, and uric acid secretion from 3T3-L1 adipocytes was increased under hypoxia. Our results suggest that purine catabolism in adipose tissue could be enhanced in obesity.
C1 [Tsushima, Yu; Nishizawa, Hitoshi; Tochino, Yoshihiro; Nakatsuji, Hideaki; Sekimoto, Ryohei; Nagao, Hirofumi; Maeda, Norikazu; Shimomura, Iichiro] Osaka Univ, Grad Sch Med, Dept Metab Med, Suita, Osaka 5650871, Japan.
   [Tsushima, Yu; Shirakura, Takashi; Kato, Kenta; Takahashi, Hiroyuki; Tamura, Mizuho] Teijin Pharma Ltd, Teijin Inst Biomed Res, Hino, Tokyo 1918512, Japan.
   [Imaizumi, Keiichiro] Teijin Ltd, Kondo Lab, Hino, Tokyo 1918512, Japan.
   [Funahashi, Tohru] Osaka Univ, Grad Sch Med, Dept Metab & Atherosclerosis, Suita, Osaka 5650871, Japan.
C3 The University of Osaka; Teijin Pharma Limited; Teijin Limited; The
   University of Osaka
RP Nishizawa, H (corresponding author), Osaka Univ, Grad Sch Med, Dept Metab Med, 2-2-B5 Yamada Oka, Suita, Osaka 5650871, Japan.
EM hitoshin1127@endmet.med.osaka-u.ac.jp
RI Maeda, Norikazu/LZI-4561-2025
OI Nagao, Hirofumi/0009-0001-1261-4160
FU Kowa Co. Ltd.;  [24591351];  [22590979];  [22126008]
FX This work was supported in part by Grants-in-aid for Scientific Research
   (C) 24591351 (to H. N.) and 22590979 (to N. M.) and by Scientific
   Research on Innovative Areas Grant 22126008 (to T. F.). Tohru Funahashi
   is a member of the Department of Metabolism and Atherosclerosis, a
   sponsored course endowed by Kowa Co. Ltd. In this work, Osaka
   University's academia-industry collaboration policy positions the
   collaboration between Osaka University and Teijin Pharma Ltd.
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NR 55
TC 290
Z9 318
U1 0
U2 30
PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3996 USA
EI 1083-351X
J9 J BIOL CHEM
JI J. Biol. Chem.
PD SEP 20
PY 2013
VL 288
IS 38
BP 27138
EP 27149
DI 10.1074/jbc.M113.485094
PG 12
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 302IG
UT WOS:000330597300013
PM 23913681
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Kuhn, A
   Ruland, V
   Patsinakidis, N
   Luger, TA
AF Kuhn, A.
   Ruland, V.
   Patsinakidis, N.
   Luger, T. A.
TI Use of methotrexate in patients with psoriasis
SO CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
LA English
DT Article
DE Methotrexate; psoriasis
ID LONG-TERM TREATMENT; CLINICAL-FEATURES; THERAPY; CYCLOSPORINE;
   COMBINATION; PATHOPHYSIOLOGY; ETANERCEPT; GUIDELINES; ARTHRITIS; PLACEBO
AB Psoriasis is considered to be a polygenetically influenced, immune-mediated, organ-specific disease of dysregulated inflammation that is triggered by environmental factors such as infections, medications, and physical and/or emotional stress. It is recognised as one of the most prevalent skin diseases, affecting 2% to 3% of Caucasian populations. Major advances in understanding of disease pathogenesis indicate that patients with psoriasis have an increased risk of comorbidities such as metabolic syndrome and cardiovascular disease. A wide range of systemic drugs have been developed in recent years for treatment of psoriasis and comorbidities. Low-dose methotrexate (MIX) is one of the classical agents and is still one of the most frequently used systemic treatments for psoriasis worldwide. Low-dose MTX is also effective in treatment of psoriatic arthritis. The mechanism of action is not fully understood, but MIX is suggested to act primarily as an anti-inflammatory and immunosuppressant drug. A favourable efficacy and safety profile has been established for MTX in a large number of clinical trials, as well as in common practice. This review summarises the nature of the disease and our present knowledge about MTX in the treatment of psoriasis, including combination therapies.
C1 [Kuhn, A.; Ruland, V.; Patsinakidis, N.; Luger, T. A.] Univ Munster, Dept Dermatol, D-48149 Munster, Germany.
C3 University of Munster
RP Kuhn, A (corresponding author), Univ Munster, Dept Dermatol, Von Esmarch Str 58, D-48149 Munster, Germany.
EM kuhnan@uni-muenster.de
RI Patsinakidis, Nikolaos/KOC-7374-2024
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NR 48
TC 18
Z9 18
U1 0
U2 9
PU CLINICAL & EXPER RHEUMATOLOGY
PI PISA
PA VIA SANTA MARIA 31, 56126 PISA, ITALY
SN 0392-856X
J9 CLIN EXP RHEUMATOL
JI Clin. Exp. Rheumatol.
PD SEP-OCT
PY 2010
VL 28
IS 5
SU 61
BP S138
EP S144
PG 7
WC Rheumatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Rheumatology
GA 677XI
UT WOS:000284028500025
PM 21044448
DA 2025-06-11
ER

PT J
AU Iyer, A
   Fairlie, DP
   Prins, JB
   Hammock, BD
   Brown, L
AF Iyer, Abishek
   Fairlie, David P.
   Prins, Johannes B.
   Hammock, Bruce D.
   Brown, Lindsay
TI Inflammatory lipid mediators in adipocyte function and obesity
SO NATURE REVIEWS ENDOCRINOLOGY
LA English
DT Review
ID SOLUBLE EPOXIDE HYDROLASE; OXYGEN SPECIES GENERATION; ACTIVATED
   RECEPTOR-DELTA; TISSUE ARACHIDONIC-ACID; CORONARY-HEART-DISEASE;
   C-REACTIVE PROTEIN; FACTOR-KAPPA-B; ADIPOSE-TISSUE; INSULIN-RESISTANCE;
   METABOLIC SYNDROME
AB Survival of multicellular organisms depends on their ability to fight infection, metabolize nutrients, and store energy for times of need. Unsurprisingly, therefore, immunoregulatory and metabolic mechanisms interact in human conditions such as obesity. Both infiltrating immunoinflammatory cells and adipocytes play critical roles in the modulation of metabolic homeostasis, so it is important to understand factors that regulate both adipocyte and immune cell function. A currently favored paradigm for obesity-associated metabolic dysfunction is that chronic macronutrient and/or lipid overload (associated with adiposity) induces cellular stress that initiates and perpetuates an inflammatory cycle and pathophysiological signaling of immunoinflammatory cells and adipocytes. Many lipid mediators exert their biological effects by binding to cognate receptors, such as G-protein-coupled receptors and Toll-like receptors. This process is tightly regulated under normal physiological conditions, and any disruption can initiate disease processes. Observations that cellular lipid loading (associated with adiposity) initiates inflammatory events has encouraged studies on the role of lipid mediators. In this review, we speculate that lipid mediators act on important immune receptors to induce low-grade tissue inflammation, which leads to adipocyte and metabolic dysfunction.
C1 [Brown, Lindsay] Univ So Queensland, Fac Sci, Toowoomba, Qld 4350, Australia.
   [Hammock, Bruce D.] Univ Calif Davis, Dept Entomol, Davis, CA 95616 USA.
   [Brown, Lindsay] Univ Calif Davis, Ctr Canc, Davis, CA 95616 USA.
   [Iyer, Abishek] Univ Queensland, Sch Biomed Sci, Brisbane, Qld 4072, Australia.
   [Fairlie, David P.] Univ Queensland, Inst Mol Biosci, Brisbane, Qld 4072, Australia.
   [Prins, Johannes B.] Univ Queensland, Diamantina Inst Canc Immunol & Metab Med, Brisbane, Qld 4072, Australia.
C3 University of Southern Queensland; University of California System;
   University of California Davis; University of California System;
   University of California Davis; University of Queensland; University of
   Queensland; University of Queensland
RP Brown, L (corresponding author), Univ So Queensland, Fac Sci, Toowoomba, Qld 4350, Australia.
EM l.brown@uq.edu.au
RI Fairlie, David/F-8865-2014; Prins, Johannes/I-3610-2019; Prins,
   Johannes/M-5884-2013; Iyer, Abishek/C-9767-2017
OI Prins, Johannes/0000-0001-9497-927X; Fairlie, David/0000-0002-7856-8566;
   Iyer, Abishek/0000-0001-9533-5265
FU NIEHS NIH HHS [P42 ES004699] Funding Source: Medline
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PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 1759-5029
EI 1759-5037
J9 NAT REV ENDOCRINOL
JI Nat. Rev. Endocrinol.
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GA 547HA
UT WOS:000273876300007
PM 20098448
DA 2025-06-11
ER

PT J
AU Kroner, Z
AF Kroner, Zina
TI The Relationship between Alzheimer's Disease and Diabetes: Type 3
   Diabetes?
SO ALTERNATIVE MEDICINE REVIEW
LA English
DT Review
ID GROWTH-FACTOR EXPRESSION; END-PRODUCTS AGES; A-BETA OLIGOMERS; METABOLIC
   SYNDROME; IMPAIRED INSULIN; MEMORY; DEMENTIA; BRAIN; RISK; MECHANISMS
AB In recent years, Alzheimer's disease (AD) has been considered to be, in part, a neuroendocrine disorder, even referred to by some as type 3 diabetes. Insulin functions by controlling neurotransmitter release processes at the synapses and activating signaling pathways associated with learning and long-term memory. Novel research demonstrates that impaired insulin signaling may be implicated in AD. Post-mortem brain studies show that insulin expression is inversely proportional to the Braak stage of AD progression. It was also demonstrated that neurotoxins, coined amyloid beta-derived diffusible ligands (ADDLs), disrupt signal transduction at synapses, making the cell insulin resistant. ADDLs reduce plasticity of the synapse, potentiate synapse loss, contribute to oxidative damage, and cause AD-type tau hyperphosphorylation. Diabetes and AD have signs of increased oxidative stress in common, including advanced glycation end products (AGES), when compared to normal subjects. Diabetic patients appear to have an increased risk for AD because AGES accumulate in neurofibrillary tangles and amyloid plaques in AD brains. This research should encourage a more proactive approach to early diagnosis of diabetes and nutritional counseling for AD patients. (Altern Med Rev 2009;14(4):373-379)
C1 [Kroner, Zina] Adv Med New York PLLC, New York, NY USA.
RP Kroner, Z (corresponding author), 121 E 60th St,Suite 3C, New York, NY 10022 USA.
EM info@advanced-medicine.com
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J9 ALTERN MED REV
JI Altern. Med. Rev.
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SC Integrative & Complementary Medicine; Pharmacology & Pharmacy
GA 538SJ
UT WOS:000273204000005
PM 20030463
DA 2025-06-11
ER

PT J
AU Upadhyay, S
   Mazumder, A
   Pentela, B
   Bansal, P
   Agarwal, N
   Baghel, DS
AF Upadhyay, Sanskriti
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   Bansal, Priyanka
   Agarwal, Neeraj
   Baghel, Dileep Singh
TI Immunological Implications in Diabetes: A Review on Various Diseases and
   Conditions
SO NATURAL PRODUCTS JOURNAL
LA English
DT Review
DE Autonomic dysfunction; cardiovascular diseases; diabetes; dyslipidemia;
   malformation of child; obesity; hypoglycaemic plants
ID CARDIOVASCULAR-DISEASE; MELLITUS; DEPRESSION; BRAIN; BETA;
   PATHOPHYSIOLOGY; HYPERGLYCEMIA; EPIDEMIOLOGY; GENETICS; OBESITY
AB Diabetes Mellitus (DM) is a long-term metabolic condition that has significant social, health, and economic consequences. There are various forms of diabetes mellitus, but the two most common varieties are type I and type II. Insulin-dependent diabetes (IDDM) is one of the most well-known autoimmune illnesses that cause insulin insufficiency and hyperglycemia by either damaging or destroying Langerhans' beta cells. Available scientific data evidenced the greatest genetic contribution of Human Leukocyte Antigen class II in the IDDM. Hyperglycemia and individual components of the insulin resistance (metabolic) syndrome put people with type II diabetes at increased risk for microvascular consequences (retinopathy, nephropathy, and neuropathy) as well as macrovascular issues (cardiovascular comorbidities). A number of pathophysiological abnormalities, including obesity, poor diet, and physical inactivity, as well as genetic variables, are involved in the disturbed glucose homeostasis associated with type II diabetes. Diseases like lipid abnormalities contribute to the progression of diabetes, whereas obesity and its related medical disorders (such as hypertension, diabetes, insulin resistance, and sleep apnea syndrome) are eventually linked to an elevated cardiovascular risk. Diabetes raises the incidence, intensity, and duration of peri-densities in people with diabetes compared to healthy persons, making it a risk factor for periodontal disease. Diabetes conditions in patients concurrently also increase the progression or risk of other diseases, i.e., cardiovascular-related diseases (hypertension, oxidative stress, hyperlipidemia), nervous system-related diseases, and COVID-19, by increasing the overall infection rate. There is widespread evidence that correlates the direct connection between diabetes and other diseases, including immunity disorders, CVS disorders, etc. This review provides a correlation between diabetes and another disease with an overall impact on the progression of cardiovascular diseases, neurological diseases, COVID-19, and periodontal diseases. This current review focuses on the collation of some plants that show antidiabetic activity, including plant part, family, chemical constituent, mechanism of action, and chemical used for extraction. Studies on the role, causes, clinical management, prevention, and treatment of diabetes heavily rely on epidemiological evidence. This review also explains different factors responsible for diabetes, like genetic factors, environmental factors, and viral infections.
C1 [Upadhyay, Sanskriti; Mazumder, Avijit; Pentela, Bhavani; Bansal, Priyanka] Noida Inst Engn & Technol, Pharm Inst, 19 Knowledge Pk 2,GB Nagar, Greater Noida 201306, Uttar Pradesh, India.
   [Agarwal, Neeraj] Noida Inst Engn & Technol, Dept Biotechnol, Plot 19,Knowledge Pk II, Greater Noida 201306, Uttar Pradesh, India.
   [Baghel, Dileep Singh] Lovely Profess Univ, Phagwara, Punjab, India.
C3 Noida Institute of Engineering & Technology; Noida Institute of
   Engineering & Technology; Lovely Professional University
RP Mazumder, A (corresponding author), Noida Inst Engn & Technol, Pharm Inst, 19 Knowledge Pk 2,GB Nagar, Greater Noida 201306, Uttar Pradesh, India.
EM avijitmazum@yahoo.com
RI Baghel, Dr. Dileep/GLR-9435-2022; bansal, priyanka/LIG-2903-2024;
   MAZUMDER, AVIJIT/I-6148-2016; Baghel, Dr. Dileep Singh/ADQ-2649-2022
OI MAZUMDER, AVIJIT/0000-0002-3053-8106; Baghel, Dr. Dileep
   Singh/0000-0002-5370-3741
FU Noida Institute of Engineering and Technology
FX The authors would like to express their profound appreciation to the
   esteemed director and administration of the Noida Institute of
   Engineering and Technology (Pharmacy Institute) for their unwavering
   cooperation and furnishing the indispensable resources essential to
   undertake this scholarly pursuit.
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NR 99
TC 0
Z9 0
U1 0
U2 2
PU BENTHAM SCIENCE PUBL
PI BUSUM
PA PO BOX 294, BUSUM, 1400 AG, NETHERLANDS
SN 2210-3155
EI 2210-3163
J9 NAT PROD J
JI Nat. Prod. J.
PY 2025
VL 15
IS 1
DI 10.2174/0122103155298605240303181317
EA APR 2024
PG 15
WC Chemistry, Medicinal
WE Emerging Sources Citation Index (ESCI)
SC Pharmacology & Pharmacy
GA L6Q9S
UT WOS:001198577900001
DA 2025-06-11
ER

PT J
AU Zhu, HB
   Yang, TZ
   Pei, T
   Ying, Y
   Peng, SH
AF Zhu, Haibao
   Yang, Tingzhong
   Pei, Tong
   Ying, Ying
   Peng, Sihui
TI The Influence of Contextual Social Deprivation on Poor Health Among
   Urban Male Residents: A Nationally Respresentative Study in China
SO AMERICAN JOURNAL OF MENS HEALTH
LA English
DT Article
DE poor health; social deprivation; socially disadvantaged populations;
   urban male residents
ID SELF-RATED HEALTH; REPRESENTATIVE NATIONWIDE; SOCIOECONOMIC-STATUS;
   METABOLIC SYNDROME; STRESS; ASSOCIATION; INDEX; WOMEN
AB This study aimed to examine whether contextual social deprivation is independently associated with health outcomes. A cross-sectional, multistage sampling design was employed to interview participants from six selected cities in China. A standardized questionnaire was used to collect data on individual socioeconomic characteristics and contextual social deprivation. Multilevel logistic regression models were used to assess the association between social deprivation and self-rated health. A total of 5,782 valid questionnaires were collected in this study. The prevalence of poor health was 5.3% (95% CI [4.2%, 6.3%]). Multilevel logistic regression analysis revealed a negative association between social deprivation and self-rated health. The odds ratios for contextual social deprivation scores of 2, 3, and 4 were 1.89 [1.31, 2.72], 4.21 [2.55, 6.94], and 4.63 [2.77, 7.73], respectively. This study offers new insights into the impact of social deprivation on poor health among urban male residents in China. The research emphasizes the urgent need to address poor health as a key measure to protect the well-being of socially and economically vulnerable populations.
C1 [Zhu, Haibao; Yang, Tingzhong; Ying, Ying] Yongkang Women & Childrens Hlth Hosp, Yongkang, Zhejiang, Peoples R China.
   [Yang, Tingzhong] Zhejiang Univ, Natl Hlth Big Data Inst, Res Ctr Digital Hlth Behav Theory & Management, Yuhangtang Rd, Hangzhou 310058, Peoples R China.
   [Yang, Tingzhong] West Virginia Univ, Injury Control Res Ctr, Morgantown, WV 26505 USA.
   [Pei, Tong] Zhejing Chinese Med Univ, Sch Humanities & Management, Hangzhou, Peoples R China.
   [Peng, Sihui] Jinan Univ, Sch Med, Guangzhou, Peoples R China.
C3 Zhejiang University; West Virginia University; Jinan University
RP Yang, TZ (corresponding author), Zhejiang Univ, Natl Hlth Big Data Inst, Res Ctr Digital Hlth Behav Theory & Management, Yuhangtang Rd, Hangzhou 310058, Peoples R China.
EM tinghzongyang@zju.edu.cn
FU National Natural Science Foundation of China [71490733]
FX The author(s) disclosed receipt of the following financialsupport for
   the research, authorship, and/or publication ofthis article: This study
   was funded by the National Natural Science Foundation of China (Grant
   No. 71490733).
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NR 62
TC 0
Z9 0
U1 0
U2 0
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1557-9883
EI 1557-9891
J9 AM J MENS HEALTH
JI Am. J. Mens Health
PD MAY
PY 2025
VL 19
IS 3
AR 15579883251332733
DI 10.1177/15579883251332733
PG 11
WC Public, Environmental & Occupational Health
WE Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA 3DO5K
UT WOS:001497788200001
PM 40433777
DA 2025-06-11
ER

PT J
AU Puri, S
   Kirad, S
   Muzaffar-Ur-Rehman, M
   Mandal, SK
   Sharma, PK
   Sankaranarayanan, M
   Deepa, PR
AF Puri, Sonakshi
   Kirad, Shivani
   Muzaffar-Ur-Rehman, Mohammed
   Mandal, Sumit Kumar
   Sharma, Pankaj Kumar
   Sankaranarayanan, Murugesan
   Deepa, P. R.
TI Lipogenic stearoyl-CoA desaturase-1 (SCD1) targeted virtual screening
   for chemical inhibitors: molecular docking / dynamics simulation and
   in vitro assessment of anti-NAFLD efficacy
SO RSC ADVANCES
LA English
DT Article
AB Amidst rising global prevalence of metabolic syndrome, the associated risk of non-alcoholic fatty liver disease (NAFLD) is also rapidly increasing. The pathogenesis of NAFLD starts with fat accumulation and progresses through inflammation and fibrotic sequel, often involving complex molecular mechanisms involving de novo lipogenesis. Stearoyl-CoA desaturase 1 (SCD1) enzyme, expressed in liver and adipose tissue, converts saturated fatty acids to monounsaturated fatty acids (MUFAs), contributing to triglyceride and cholesterol ester formation. In this study, potential SCD1 inhibitors were screened using the ZINC database of curated medically-approved drugs by virtual screening, molecular docking, and molecular dynamics simulations. The top-scoring five ligands with strong binding affinity against SCD1 were ZINC000003831151 > ZINC000001540998 > ZINC000003830713 > ZINC000000897251 > ZINC000002005305, which showed stable protein-ligand complexation and favorable pharmacokinetic attributes. The top ligand, Montelukast, was experimentally validated for its pharmacological efficacy in an in vitro cell culture model of steatosis (NAFLD). Montelukast showed a dose-dependent decrease in hepatic fat accumulation, reduced levels of free radicals, and lowered oxidative stress (P < 0.05). These outcomes suggest Montelukast to be a potential SCD1 inhibitor, with anti-NAFLD efficacy. These findings open new avenues for therapeutic development of the top 5 ligands in metabolic disorders involving SCD1.
C1 [Puri, Sonakshi; Mandal, Sumit Kumar; Sharma, Pankaj Kumar; Deepa, P. R.] Birla Inst Technol & Sci Pilani, Dept Biol Sci, Biochem & Enzyme Biotechnol Lab, Pilani Campus, Pilani 333031, Rajasthan, India.
   [Kirad, Shivani; Muzaffar-Ur-Rehman, Mohammed; Sankaranarayanan, Murugesan] Birla Inst Technol & Sci Pilani, Dept Pharm, Med Chem Res Lab, Pilani Campus, Pilani 333031, Rajasthan, India.
C3 Birla Institute of Technology & Science Pilani (BITS Pilani); Birla
   Institute of Technology & Science Pilani (BITS Pilani)
RP Deepa, PR (corresponding author), Birla Inst Technol & Sci Pilani, Dept Biol Sci, Biochem & Enzyme Biotechnol Lab, Pilani Campus, Pilani 333031, Rajasthan, India.; Sankaranarayanan, M (corresponding author), Birla Inst Technol & Sci Pilani, Dept Pharm, Med Chem Res Lab, Pilani Campus, Pilani 333031, Rajasthan, India.
EM murugesan@pilani.bits-pilani.ac.in; deepa@pilani.bits-pilani.ac.in
OI Sankaranarayanan, Murugesan/0000-0002-3680-1577
FU Indian Council of Medical Research [52/13/2022-BIO/BMS]; Indian Council
   of Medical Research (ICMR), New Delhi; BITS Pilani; BITS Pilani, Pilani
   campus
FX This work was supported by a research grant from the Indian Council of
   Medical Research (ICMR), New Delhi (Grant No. 52/13/2022-BIO/BMS). SP,
   SK, MMR, and SKM acknowledge the Institute Fellowship from BITS Pilani.
   The authors are grateful to the administration of BITS Pilani, Pilani
   campus, for providing necessary providing research support and
   computational infrastructure.
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NR 29
TC 0
Z9 0
U1 4
U2 8
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
EI 2046-2069
J9 RSC ADV
JI RSC Adv.
PD OCT 1
PY 2024
VL 14
IS 43
BP 31797
EP 31808
DI 10.1039/d4ra06037g
PG 12
WC Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry
GA I5O1N
UT WOS:001330742000001
PM 39380655
OA gold
DA 2025-06-11
ER

PT J
AU Knapp, M
   Gorski, J
AF Knapp, M.
   Gorski, J.
TI ENDOTHELIAL LIPASE: REGULATION AND BIOLOGICAL FUNCTION
SO JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
LA English
DT Review
DE endothelial lipase; angiopoietin-like protein; regulation of expression;
   plasma lipoproteins; atherosclerosis; exercise; lipolysis; triglyceride
ID HIGH-DENSITY-LIPOPROTEIN; FAMILIAL COMBINED HYPOLIPIDEMIA; REVERSE
   CHOLESTEROL TRANSPORT; CELL-DERIVED LIPASE; HDL CHOLESTEROL;
   PLASMA-LIPIDS; TRIGLYCERIDE LIPASE; PHYSICAL-ACTIVITY; HEART-DISEASE;
   ATHEROSCLEROSIS
AB Endothelial lipase is synthetized almost exclusively in endothelial cells and then fixed on the luminal surface of the endothelium by means of heparan sulphate proteoglycans. The enzyme is expressed in the endothelium of nearly all tissues and the degree of expression is higher in richly vascularized tissues than in the less vascularized ones. The endothelial lipase expression in tissues is upregulated by shear and cyclic stress, angiotensin II and hypertension. The plasma enzyme level is elevated by pro-inflammatory cytokines, in metabolic syndrome and obesity. Prolonged exercise reduces the plasma enzyme level in the rat. The activity of the enzyme is inhibited by: sphingomyelin, angiopoietin-like protein 3 and 4, and insulin. Endothelial lipase reduces the plasma high density lipoprotein concentration and changes its properties. The enzyme is considered to be the main regulator of the plasma high density lipoprotein concentration. The plasma endothelial lipase concentration is elevated in coronary atherosclerosis and it is inversely correlated with the plasma high density lipoprotein level. The enzyme is considered to exert mostly pro-atherogenic effects. Its action as triglyceride lipase is important in hypertriglyceridemia.
C1 [Knapp, M.] Med Univ Bialystok, Dept Cardiol, Bialystok, Poland.
   [Gorski, J.] Acad Appl Sci, Dept Med Sci, 14 Akad St, PL-18400 Lomza, Poland.
C3 Medical University of Bialystok
RP Gorski, J (corresponding author), Acad Appl Sci, Dept Med Sci, 14 Akad St, PL-18400 Lomza, Poland.
EM gorski@ansl.edu.pl
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NR 93
TC 7
Z9 7
U1 0
U2 7
PU POLISH PHYSIOLOGICAL SOC
PI GRZEGORZECKA
PA JAGIELLONIAN UNIV SCHOOL MED, INST PHYSIOLOGY, 31-531 KRAKOW, 16
   GRZEGORZECKA, POLAND
SN 0867-5910
J9 J PHYSIOL PHARMACOL
JI J. Physiol. Pharmacol.
PD JUN
PY 2022
VL 73
IS 3
BP 329
EP 336
DI 10.26402/jpp.2022.3.01
PG 8
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA 8L4XJ
UT WOS:000923786000001
PM 36302529
DA 2025-06-11
ER

PT J
AU Talib, WH
   Mahmod, AI
   Abuarab, SF
   Hasen, E
   Munaim, AA
   Haif, SK
   Ayyash, AM
   Khater, S
   AL-Yasari, IH
   Kury, LTA
AF Talib, Wamidh H.
   Mahmod, Asma Ismail
   Abuarab, Sara Feras.
   Hasen, Eliza
   Munaim, Amer A.
   Haif, Shatha Khaled
   Ayyash, Amani Marwan
   Khater, Samar
   AL-Yasari, Intisar Hadi
   Kury, Lina T. Al
TI Diabetes and Cancer: Metabolic Association, Therapeutic Challenges, and
   the Role of Natural Products
SO MOLECULES
LA English
DT Review
DE hyperglycemia; cancer; Warburg effect; alternative therapies; obesity;
   metabolic syndrome; hyperinsulinemia; cancer metabolism; oxidative
   stress; natural products
ID CELL LUNG-CANCER; GROWTH-FACTOR-I; PROSTATE-SPECIFIC ANTIGEN; SERUM
   C-PEPTIDE; BREAST-CANCER; HEPATOCELLULAR-CARCINOMA; INSULIN-RESISTANCE;
   PANCREATIC-CANCER; GLUCOCORTICOID THERAPY; LUTEOLIN SUPPRESSES
AB Cancer is considered the second leading cause of death worldwide and in 2018 it was responsible for approximately 9.6 million deaths. Globally, about one in six deaths are caused by cancer. A strong correlation was found between diabetes mellitus and carcinogenesis with the most evident correlation was with type 2 diabetes mellitus (T2DM). Research has proven that elevated blood glucose levels take part in cell proliferation and cancer cell progression. However, limited studies were conducted to evaluate the efficiency of conventional therapies in diabetic cancer patients. In this review, the correlation between cancer and diabetes will be discussed and the mechanisms by which the two diseases interact with each other, as well as the therapeutics challenges in treating patients with diabetes and cancer with possible solutions to overcome these challenges. Natural products targeting both diseases were discussed with detailed mechanisms of action. This review will provide a solid base for researchers and physicians to test natural products as adjuvant alternative therapies to treat cancer in diabetic patients.
C1 [Talib, Wamidh H.; Mahmod, Asma Ismail; Abuarab, Sara Feras.; Hasen, Eliza; Munaim, Amer A.; Haif, Shatha Khaled; Ayyash, Amani Marwan; Khater, Samar] Appl Sci Private Univ, Dept Clin Pharm & Therapeut, Amman 11931166, Jordan.
   [AL-Yasari, Intisar Hadi] Al Qasim Green Univ, Dept Genet Engn, Coll Biotechnol, Babylon 00964, Iraq.
   [Kury, Lina T. Al] Zayed Univ, Dept Hlth Sci, Coll Nat & Hlth Sci, Abu Dhabi 144534, U Arab Emirates.
C3 Applied Science University - Jordan; Al Qasim Green University; Zayed
   University
RP Talib, WH (corresponding author), Appl Sci Private Univ, Dept Clin Pharm & Therapeut, Amman 11931166, Jordan.
EM w_talib@asu.edu.jo; asmamahmod1212@gmail.com; saraarab97@yahoo.com;
   elyzahasan97@gmail.com; am00er97@gmail.com; shaza-haif@hotmail.com;
   amaniayyash@gmail.com; samar_ktr@asu.edu.jo;
   entesar@biotech.uoqasim.edu.iq; Lina.AlKury@zu.ac.ae
RI khater, Samar/AAA-3678-2019; Talib, Wamidh/H-9831-2017; Ayyash,
   Amani/MGB-0700-2025; Al-Khattab, Amer/AAO-4398-2021; Al Kury,
   Lina/Y-3421-2019; Mahmod, Asma/AGG-9726-2022
OI Hasen, Eliza/0000-0001-7669-4772; Khater, Samar/0000-0001-7563-4815;
   Talib, Wamidh H./0000-0003-1942-8982; Ayyash, Amani
   Marwan/0000-0001-8246-1473; Al Kury, Lina/0000-0002-8338-7655; Mahmod,
   Asma/0000-0002-4591-7408; Haif, Shatha/0000-0001-7240-9575
FU Applied Science Private University, Amman, Jordan [DRGS-2020-2021-4]
FX The authors are grateful to the Applied Science Private University,
   Amman, Jordan, for the full financial support granted to this research
   (Grant No. DRGS-2020-2021-4).
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NR 285
TC 15
Z9 20
U1 7
U2 30
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1420-3049
J9 MOLECULES
JI Molecules
PD APR
PY 2021
VL 26
IS 8
AR 2179
DI 10.3390/molecules26082179
PG 31
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA RT6SG
UT WOS:000644588400001
PM 33920079
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Kim, JY
   He, F
   Karin, M
AF Kim, Ju Youn
   He, Feng
   Karin, Michael
TI From Liver Fat to Cancer: Perils of the Western Diet
SO CANCERS
LA English
DT Review
DE obesity; cholesterol; NAFLD; NASH; HCC
ID ENDOPLASMIC-RETICULUM STRESS; DENSITY-LIPOPROTEIN-CHOLESTEROL; FARNESOID
   X RECEPTOR; NONALCOHOLIC STEATOHEPATITIS; HEPATIC STEATOSIS;
   TRANSCRIPTION FACTOR; METABOLIC SYNDROME; HEPATOCELLULAR-CARCINOMA;
   OBETICHOLIC ACID; CLINICAL-SIGNIFICANCE
AB Simple Summary
   Non-alcoholic steatohepatitis (NASH) is a common liver disease, characterized by fatty liver, chronic tissue damage, inflammation and fibrosis. NASH greatly increases the risk of the most common liver cancer, hepatocellular carcinoma (HCC), a leading cause of cancer related deaths worldwide. Here, we discuss how the Western Diet contributes to NASH and HCC development with a special emphasis on the roles of cholesterol and different metabolic regulators.
   Hepatocellular carcinoma (HCC), the most common type of primary liver cancer provides the prototypical example of an obesity-related cancer. The obesity epidemic gave rise to an enormous increase in the incidence of non-alcoholic fatty liver disease (NAFLD), a condition that affects one third of American adults. In about 20% of these individuals, simple liver steatosis (hepatosteatosis) progresses to non-alcoholic steatohepatitis (NASH) characterized by chronic liver injury, inflammation, and fibrosis. In addition to liver failure, NASH greatly increases the risk of HCC. Here we discuss the metabolic processes that control the progression from NAFLD to NASH and from NASH to HCC, with a special emphasis on the role of free-non-esterified cholesterol in the process.
C1 [Kim, Ju Youn; Karin, Michael] Univ Calif San Diego, Lab Gene Regulat & Signal Transduct, Dept Pharmacol, 9500 Gilman Dr, San Diego, CA 92093 USA.
   [Kim, Ju Youn; Karin, Michael] Univ Calif San Diego, Lab Gene Regulat & Signal Transduct, Dept Pathol, 9500 Gilman Dr, San Diego, CA 92093 USA.
   [He, Feng] Shanghai Univ Tradit Chinese Med, Acad Integrat Med, 1200 Cailun Rd, Shanghai 201203, Peoples R China.
C3 University of California System; University of California San Diego;
   University of California System; University of California San Diego;
   Shanghai University of Traditional Chinese Medicine
RP Karin, M (corresponding author), Univ Calif San Diego, Lab Gene Regulat & Signal Transduct, Dept Pharmacol, 9500 Gilman Dr, San Diego, CA 92093 USA.; Karin, M (corresponding author), Univ Calif San Diego, Lab Gene Regulat & Signal Transduct, Dept Pathol, 9500 Gilman Dr, San Diego, CA 92093 USA.
EM juk005@ucsd.edu; fhe@shutcm.edu.cn; karinoffice@ucsd.edu
RI Kim, Juyoun/GNW-6324-2022; He, Feng/J-6984-2019
OI He, Feng/0000-0003-0276-3303
FU Eli Lilly LIFA program; NIH [R01DK120714, R01CA211794, R01CA234128];
   Superfund Basic Research Program [P42-ES010337]; Ben Wanda Hildyard
   Chair for Mitochondrial and Metabolic Diseases; National Cancer
   Institute [R01CA211794] Funding Source: NIH RePORTER; National Institute
   of Environmental Health Sciences [P42ES010337] Funding Source: NIH
   RePORTER
FX Feng He was supported by the Eli Lilly LIFA program. Research in M.
   Karin's lab is supported by NIH (R01DK120714, R01CA211794, and
   R01CA234128) and the Superfund Basic Research Program (P42-ES010337).
   M.K. holds the Ben Wanda Hildyard Chair for Mitochondrial and Metabolic
   Diseases.
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NR 153
TC 24
Z9 24
U1 0
U2 18
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6694
J9 CANCERS
JI Cancers
PD MAR
PY 2021
VL 13
IS 5
AR 1095
DI 10.3390/cancers13051095
PG 19
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA QV5EF
UT WOS:000627994000001
PM 33806428
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Schisano, C
   Narciso, V
   Maisto, M
   Annunziata, G
   Grieco, P
   Sommella, EM
   Tenore, GC
   Novellino, E
AF Schisano, Connie
   Narciso, Viviana
   Maisto, Maria
   Annunziata, Giuseppe
   Grieco, Paolo
   Sommella, Eduardo Maria
   Tenore, Gian Carlo
   Novellino, Ettore
TI In vitro effects of protein fractions from Controne beans (Phaseolus
   vulgaris L. ecotype Controne) on intestinal permeability, ACE and
   α-amylase activities
SO EUROPEAN FOOD RESEARCH AND TECHNOLOGY
LA English
DT Article
DE ACE inhibition; Alpha-amylase inhibition; Anti-radical activity; Bean;
   Intestinal permeability; Protein extract
ID ANTIOXIDANT ACTIVITY; METABOLIC SYNDROME; OXIDATIVE STRESS; BOVINE
   COLOSTRUM; PEPTIDES; GUT; BIOAVAILABILITY; PATHOGENESIS; LUBIPROSTONE;
   GROWTH
AB Recent studies suggest that different types of milk-derived proteins or peptides might be active as antihypertensive, antioxidant, immunomodulatory and antimicrobial agents. Nonetheless, the research of an alternative source of bioactive peptides to avoid the different types of allergy and intolerance, caused by milk protein, could be hypothesised. Controne bean (Phaseolus vulgaris L. ecotype Controne) is a typical legume variety from Campania region (Controne Municipality, Salerno, Italy), characterised, on average, by a protein content of 22%. Thus, the aim of this study was to evaluate the in vitro effect of protein extracts (PEs) from different bean cultivars, such as Controne, Spanish White and Cannellini, to verify some peculiar biological properties, such as antiradical, anti alpha-amylase and angiotensin converting enzyme (ACE) inhibitory activities, as well as to test in vitro the potential influence of PEs on intestinal permeability. The most promising results were provided by Controne cultivar; in particular: antiradical effect, 80%; lactulose/mannitol ratio, LMR, 0.198; alpha-amylase inhibition, 70%; ACE inhibition, 62%. These results suggest that Controne bean PE may be of interest for potential nutraceutical applications.
C1 [Schisano, Connie; Narciso, Viviana; Maisto, Maria; Annunziata, Giuseppe; Grieco, Paolo; Sommella, Eduardo Maria; Tenore, Gian Carlo; Novellino, Ettore] Univ Napoli Federico II, Dept Pharm, Via D Montesano 49, I-80131 Naples, Italy.
C3 University of Naples Federico II
RP Schisano, C (corresponding author), Univ Napoli Federico II, Dept Pharm, Via D Montesano 49, I-80131 Naples, Italy.
EM connie.schisano@unina.it; viviana.narciso@gmail.com;
   maria.maisto@unina.it; giuseppe.annunziata@unina.it;
   paolo.grieco@unina.it; esommella@unisa.it; gctenore@unina.it;
   ettore.novellino@unina.it
RI Grieco, Paolo/AAB-9034-2019; Annunziata, Giuseppe/W-2529-2019
OI Sommella, Eduardo/0000-0001-8654-6431; Annunziata,
   Giuseppe/0000-0002-1922-662X
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NR 42
TC 7
Z9 7
U1 0
U2 18
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1438-2377
EI 1438-2385
J9 EUR FOOD RES TECHNOL
JI Eur. Food Res. Technol.
PD OCT
PY 2019
VL 245
IS 10
BP 2311
EP 2322
DI 10.1007/s00217-019-03338-5
PG 12
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA JA2MP
UT WOS:000487651100021
DA 2025-06-11
ER

PT J
AU Teo, E
   Batchu, KC
   Barardo, D
   Xiao, LF
   Cazenave-Gassiot, A
   Tolwinski, N
   Wenk, M
   Halliwell, B
   Gruber, J
AF Teo, Emelyne
   Batchu, Krishna Chaithanya
   Barardo, Diogo
   Xiao, Linfan
   Cazenave-Gassiot, Amaury
   Tolwinski, Nicholas
   Wenk, Markus
   Halliwell, Barry
   Gruber, Jan
TI A novel vibration-induced exercise paradigm improves fitness and lipid
   metabolism of Caenorhabditis elegans
SO SCIENTIFIC REPORTS
LA English
DT Article
ID WHOLE-BODY VIBRATION; PHYSICAL-ACTIVITY; LIFE-SPAN; C-ELEGANS; SEDENTARY
   BEHAVIOR; STRESS RESISTANCE; AEROBIC EXERCISE; ELDERLY-PATIENTS; MUSCLE
   STRENGTH; HEALTH
AB Exercise has been known to reduce the risk of obesity and metabolic syndrome, but the mechanisms underlying many exercise benefits remain unclear. This is, in part, due to a lack of exercise paradigms in invertebrate model organisms that would allow rapid mechanistic studies to be conducted. Here we report a novel exercise paradigm in Caenorhabditis elegans (C. elegans) that can be implemented under standard laboratory conditions. Mechanical stimulus in the form of vibration was transduced to C. elegans grown on solid agar media using an acoustic actuator. One day post-exercise, the exercised animals showed greater physical fitness compared to the un-exercised controls. Despite having higher mitochondrial reactive oxygen species levels, no mitohormetic adaptations and lifespan extension were observed in the exercised animals. Nonetheless, exercised animals showed lower triacylglycerides (TAG) accumulation than the controls. Among the individual TAG species, the most significant changes were found in mono-and polyunsaturated fatty acid residues. Such alteration resulted in an overall lower double bond index and peroxidation index which measure susceptibility towards lipid peroxidation. These observations are consistent with findings from mammalian exercise literature, suggesting that exercise benefits are largely conserved across different animal models.
C1 [Teo, Emelyne] Natl Univ Singapore, NUS Grad Sch Integrat Sci & Engn, Singapore, Singapore.
   [Cazenave-Gassiot, Amaury; Wenk, Markus] Natl Univ Singapore, Singapore Lipid Incubator, Singapore, Singapore.
   [Barardo, Diogo; Cazenave-Gassiot, Amaury; Wenk, Markus; Halliwell, Barry; Gruber, Jan] Natl Univ Singapore, Dept Biochem, Singapore, Singapore.
   [Batchu, Krishna Chaithanya; Barardo, Diogo; Xiao, Linfan; Tolwinski, Nicholas; Gruber, Jan] Yale NUS Coll, Sci Div, Singapore, Singapore.
C3 National University of Singapore; National University of Singapore;
   National University of Singapore; Yale NUS College
RP Gruber, J (corresponding author), Natl Univ Singapore, Dept Biochem, Singapore, Singapore.; Gruber, J (corresponding author), Yale NUS Coll, Sci Div, Singapore, Singapore.
EM jangruber467@gmail.com
RI Wenk, Markus/D-1441-2014; Halliwell, Barry/C-8318-2009; Barardo,
   Diogo/GVR-8783-2022; Tolwinski, Nicholas/Q-5782-2019; Cazenave-Gassiot,
   Amaury/E-4536-2014
OI Cazenave-Gassiot, Amaury/0000-0002-3050-634X; Halliwell,
   Barry/0000-0002-3560-7123; Tolwinski, Nicholas/0000-0002-8507-2737
FU NIH Office of Research Infrastructure Programs [P40 OD010440]; Ministry
   of Education Singapore [R-184-000-230-112, 2014-T2-2-120, IG17-LR006];
   Yale-NUS start-up grant; NUS Graduate School for Integrative Sciences
   and Engineering
FX Some strains were provided by the CGC, which is funded by NIH Office of
   Research Infrastructure Programs (P40 OD010440). We thank the funding
   provided by Ministry of Education Singapore (Grant R-184-000-230-112,
   2014-T2-2-120 and IG17-LR006), Yale-NUS start-up grant and NUS Graduate
   School for Integrative Sciences and Engineering.
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NR 64
TC 7
Z9 10
U1 0
U2 7
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD JUN 20
PY 2018
VL 8
AR 9420
DI 10.1038/s41598-018-27330-3
PG 15
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA GJ8HQ
UT WOS:000435630400025
PM 29925926
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Burrage, LC
   Nagamani, SCS
   Campeau, PM
   Lee, BH
AF Burrage, Lindsay C.
   Nagamani, Sandesh C. S.
   Campeau, Philippe M.
   Lee, Brendan H.
TI Branched-chain amino acid metabolism: from rare Mendelian diseases to
   more common disorders
SO HUMAN MOLECULAR GENETICS
LA English
DT Article
ID SYRUP-URINE-DISEASE; ALPHA-KETO-ACIDS; DOMINO LIVER-TRANSPLANTATION;
   BRAIN ENERGY-METABOLISM; UREA CYCLE DISORDERS; OXIDATIVE STRESS;
   INBORN-ERRORS; BIOCHEMICAL BASIS; INTERMEDIATE-FILAMENTS; DEHYDROGENASE
   COMPLEX
AB Branched-chain amino acid (BCAA) metabolism plays a central role in the pathophysiology of both rare inborn errors of metabolism and the more common multifactorial diseases. Although deficiency of the branched-chain ketoacid dehydrogenase(BCKDC) and associated elevations in the BCAAs and their ketoacids have been recognized as the cause of maple syrup urine disease (MSUD) for decades, treatment options for this disorder have been limited to dietary interventions. In recent years, the discovery of improved leucine tolerance after liver transplantation has resulted in a new therapeutic strategy for this disorder. Likewise, targeting the regulation of the BCKDC activity may be an alternative potential treatment strategy for MSUD. The regulation of the BCKDC by the branched-chain ketoacid dehydrogenase kinase has also been implicated in a new inborn error of metabolism characterized by autism, intellectual disability and seizures. Finally, there is a growing body of literature implicating BCAA metabolism in more common disorders such as the metabolic syndrome, cancer and hepatic disease. This review surveys the knowledge acquired on the topic over the past 50 years and focuses on recent developments in the field of BCAA metabolism.
C1 [Burrage, Lindsay C.; Nagamani, Sandesh C. S.; Lee, Brendan H.] Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA.
   [Campeau, Philippe M.] Univ Montreal, Dept Pediat, Montreal, PQ H3C 3J7, Canada.
   [Lee, Brendan H.] Howard Hughes Med Inst, Houston, TX 77030 USA.
C3 Baylor College of Medicine; Universite de Montreal; Howard Hughes
   Medical Institute
RP Lee, BH (corresponding author), Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA.
EM blee@bcm.edu
RI ; Campeau, Philippe/J-8614-2015
OI Nagamani, Sandesh/0000-0001-6818-7367; Campeau,
   Philippe/0000-0001-9713-7107
FU ACMG Foundation/Genzyme Biochemical Genetics Fellowship; Clinical
   Scientist Development Award by the Doris Duke Charitable Foundation;
   O'Malley Foundation Research Fellowship; NIH [DK92921]; Baylor College
   of Medicine General Clinical Research Center [RR00188]; BCM Intellectual
   and Developmental Disabilities Research Center [HD024064]; Eunice
   Kennedy Shriver National Institute Of Child Health & Human Development;
   Urea Cycle Disorders Research Consortium a part of the National
   Institutes of Health (NIH) Rare Diseases Clinical Research Network
   (RDCRN) [U54 HD061221]; NIH Office of Rare Diseases Research (ORDR) at
   the National Center for Advancing Translational Science (NCATS); NICHD
FX L.C.B. is supported by the ACMG Foundation/Genzyme Biochemical Genetics
   Fellowship. S.C.S.N. is supported by the Clinical Scientist Development
   Award by the Doris Duke Charitable Foundation. P.M.C. was supported by
   the O'Malley Foundation Research Fellowship. This work was supported by
   the NIH (DK92921 to B.L.), Baylor College of Medicine General Clinical
   Research Center (RR00188), the BCM Intellectual and Developmental
   Disabilities Research Center (HD024064) from the Eunice Kennedy Shriver
   National Institute Of Child Health & Human Development and the Urea
   Cycle Disorders Research Consortium (U54 HD061221, a part of the
   National Institutes of Health (NIH) Rare Diseases Clinical Research
   Network (RDCRN), supported through collaboration between the NIH Office
   of Rare Diseases Research (ORDR) at the National Center for Advancing
   Translational Science (NCATS) and the NICHD. The content is solely the
   responsibility of the authors and does not necessarily represent the
   official views of the National Institutes of Health.
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NR 107
TC 109
Z9 123
U1 0
U2 31
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0964-6906
EI 1460-2083
J9 HUM MOL GENET
JI Hum. Mol. Genet.
PD SEP 15
PY 2014
VL 23
SI 1
BP R1
EP R8
DI 10.1093/hmg/ddu123
PG 8
WC Biochemistry & Molecular Biology; Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Genetics & Heredity
GA CB7RS
UT WOS:000349825700001
PM 24651065
OA Green Published
DA 2025-06-11
ER

PT J
AU Sparks, JD
   Sparks, CE
   Adeli, K
AF Sparks, Janet D.
   Sparks, Charles E.
   Adeli, Khosrow
TI Selective Hepatic Insulin Resistance, VLDL Overproduction, and
   Hypertriglyceridemia
SO ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
LA English
DT Article
DE apolipoproteins; cytokines; insulin resistance; lipoproteins; obesity
ID TRIGLYCERIDE TRANSFER PROTEIN; LOW-DENSITY-LIPOPROTEIN; APOLIPOPROTEIN-B
   SECRETION; ENDOPLASMIC-RETICULUM STRESS; NECROSIS-FACTOR-ALPHA;
   UBIQUITIN-PROTEASOME PATHWAY; MESSENGER-RNA TRANSLATION;
   TYROSINE-PHOSPHATASE 1B; FED HAMSTER MODEL; NF-KAPPA-B
AB Insulin plays a central role in regulating energy metabolism, including hepatic transport of very low-density lipoprotein (VLDL)-associated triglyceride. Hepatic hypersecretion of VLDL and consequent hypertriglyceridemia leads to lower circulating high-density lipoprotein levels and generation of small dense low-density lipoproteins characteristic of the dyslipidemia commonly observed in metabolic syndrome and type 2 diabetes mellitus. Physiological fluctuations of insulin modulate VLDL secretion, and insulin inhibition of VLDL secretion upon feeding may be the first pathway to become resistant in obesity that leads to VLDL hypersecretion. This review summarizes the role of insulin-related signaling pathways that determine hepatic VLDL production. Disruption in signaling pathways that reduce generation of the second messenger phosphatidylinositide (3,4,5) triphosphate downstream of activated phosphatidylinositide 3-kinase underlies the development of VLDL hypersecretion. As insulin resistance progresses, a number of pathways are altered that further augment VLDL hypersecretion, including hepatic inflammatory pathways. Insulin plays a complex role in regulating glucose metabolism, and it is not surprising that the role of insulin in VLDL and lipid metabolism will prove equally complex. (Arterioscler Thromb Vasc Biol. 2012;32:2104-2112.)
C1 [Adeli, Khosrow] Univ Toronto, Hosp Sick Children, Res Inst, Toronto, ON M5G 1X8, Canada.
   [Sparks, Janet D.; Sparks, Charles E.] Univ Rochester, Med Ctr, Dept Pathol & Lab Med, Rochester, NY 14642 USA.
C3 University of Toronto; Hospital for Sick Children (SickKids); University
   of Rochester
RP Adeli, K (corresponding author), Univ Toronto, Hosp Sick Children, Res Inst, 555 Univ Ave, Toronto, ON M5G 1X8, Canada.
EM khosrow.adeli@sickkids.ca
OI Sparks, Janet/0000-0002-0072-766X; Adeli, Khosrow/0000-0002-5839-5709
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TC 175
Z9 192
U1 1
U2 21
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1079-5642
EI 1524-4636
J9 ARTERIOSCL THROM VAS
JI Arterioscler. Thromb. Vasc. Biol.
PD SEP
PY 2012
VL 32
IS 9
BP 2104
EP 2112
DI 10.1161/ATVBAHA.111.241463
PG 9
WC Hematology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Hematology; Cardiovascular System & Cardiology
GA 992JZ
UT WOS:000307773100012
PM 22796579
OA Bronze
DA 2025-06-11
ER

PT J
AU Kim, MK
   Chanda, D
   Lee, IK
   Choi, HS
   Park, KG
AF Kim, Mi-Kyung
   Chanda, Dipanjan
   Lee, In-Kyu
   Choi, Hueng-Sik
   Park, Keun-Gyu
TI Targeting orphan nuclear receptor SHP in the treatment of metabolic
   diseases
SO EXPERT OPINION ON THERAPEUTIC TARGETS
LA English
DT Review
ID SMALL-HETERODIMER-PARTNER; PLASMINOGEN-ACTIVATOR INHIBITOR-1;
   GROWTH-FACTOR-BETA; ENDOPLASMIC-RETICULUM STRESS; NEGATIVE
   FEEDBACK-REGULATION; INSULIN GENE-EXPRESSION; CHRONIC KIDNEY-DISEASE;
   BILE-ACID SYNTHESIS; DNA-BINDING DOMAIN; X-RECEPTOR
AB Importance of the field: The orphan nuclear receptor small heterodimer partner (SHP; NR0B2) is an atypical nuclear receptor that contains a ligand-binding domain, but lacks the conserved DNA-binding domain. Since its discovery, SHP has been identified as a key transcriptional regulatory factor of genes involved in diverse metabolic pathways.
   Areas covered in this review: We performed a Medline/Pubmed search to find published studies on the role of SHP in the regulation of metabolism in the liver, pancreatic islets, blood vessel, and kidney and on the feasibility of using SHP as a therapeutic target in metabolic disease.
   What the reader will gain: In this review, we discuss the function of SHP as regulator of cholesterol, lipid and glucose metabolism, and the role of SHP in metabolic and fibrotic diseases.
   Take home message: The reviewed studies suggested that SHP could be a major target for therapeutic intervention in metabolic and fibrotic diseases, including metabolic syndrome and its complications. However, for SHP-targeted therapy, there are some outstanding issues, including the small number of known inducers of SHP and the lack of sufficient data in humans.
C1 [Kim, Mi-Kyung; Park, Keun-Gyu] Keimyung Univ, Sch Med, Dept Internal Med, Taegu 700712, South Korea.
   [Chanda, Dipanjan; Choi, Hueng-Sik] Chonnam Natl Univ, Hormone Res Ctr, Sch Biol Sci & Technol, Kwangju 500757, South Korea.
   [Lee, In-Kyu] Kyungpook Natl Univ, Sch Med, Dept Internal Med, Taegu 700721, South Korea.
   [Choi, Hueng-Sik] Chonnam Natl Univ, Res Inst Med Sci, Dept Biomed Sci, Kwangju 500757, South Korea.
C3 Keimyung University; Chonnam National University; Kyungpook National
   University (KNU); Chonnam National University
RP Park, KG (corresponding author), Keimyung Univ, Sch Med, Dept Internal Med, Taegu 700712, South Korea.
EM hsc@chonnam.ac.kr; kgpark@dsmc.or.kr
RI Chanda, Dipanjan/AAU-3996-2021; Lee, In-Kyu/AAR-6374-2021
OI Chanda, Dipanjan/0000-0003-0685-187X
FU Ministry for Health, Welfare & Family Affairs, Republic of Korea
   [A08-4335-AA2004-08N1-00020B]
FX This study was supported by a grant from the Korea Healthcare Technology
   R&D Project, Ministry for Health, Welfare & Family Affairs, Republic of
   Korea (A08-4335-AA2004-08N1-00020B). The authors disclose no conflicts
   of interest in the current work.
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NR 119
TC 20
Z9 23
U1 0
U2 7
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1472-8222
EI 1744-7631
J9 EXPERT OPIN THER TAR
JI Expert Opin. Ther. Targets
PD APR
PY 2010
VL 14
IS 4
BP 453
EP 466
DI 10.1517/14728221003652463
PG 14
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 568QC
UT WOS:000275536400008
PM 20230197
DA 2025-06-11
ER

PT J
AU Gyawali, P
   Martin, SA
   Heilbronn, LK
   Vincent, AD
   Taylor, AW
   Adams, RJT
   O'Loughlin, PD
   Wittert, GA
AF Gyawali, Prabin
   Martin, Sean A.
   Heilbronn, Leonie K.
   Vincent, Andrew D.
   Taylor, Anne W.
   Adams, Robert J. T.
   O'Loughlin, Peter D.
   Wittert, Gary A.
TI The role of sex hormone-binding globulin (SHBG), testosterone, and other
   sex steroids, on the development of type 2 diabetes in a cohort of
   community-dwelling middle-aged to elderly men
SO ACTA DIABETOLOGICA
LA English
DT Article
DE Sex hormone-binding globulin; Testosterone; Men's health; Type 2
   diabetes
ID NUTRITION EXAMINATION SURVEY; 3RD NATIONAL-HEALTH; INSULIN-RESISTANCE;
   METABOLIC SYNDROME; OLDER MEN; RISK; MELLITUS; ASSOCIATION; WOMEN; SERUM
AB Contrasting findings exist regarding the association between circulating sex hormone-binding globulin (SHBG) and testosterone levels and type 2 diabetes (T2D) in men. We examined prospective associations of SHBG and sex steroids with incident T2D in a cohort of community-dwelling men.
   Participants were from a cohort study of community-dwelling (n = 2563), middle-aged to elderly men (35-80 years) from Adelaide, Australia (the Men Androgen Inflammation Lifestyle Environment and Stress (MAILES) study). The current study included men who were followed for 5 years and with complete SHBG and sex steroid levels (total testosterone (TT), dihydrotestosterone (DHT) and oestradiol (E2)), but without T2D at baseline (n = 1597). T2D was identified by either self-report, fasting glucose (ae 7.0 mmol/L), HbA1c (ae 6.5%/48.0 mmol/mol), and/or prescriptions for diabetes medications. Logistic binomial regression was used to assess associations between SHBG, sex steroids and incident T2D, adjusting for confounders including age, smoking status, physical activity, adiposity, glucose, triglycerides, symptomatic depression, SHBG and sex steroid levels.
   During an average follow-up of 4.95 years, 14.5% (n = 232) of men developed new T2D. Multi-adjusted models revealed an inverse association between baseline SHBG, TT, and DHT levels, and incident T2D (odds ratio (OR) = 0.77, 95% CI [0.62, 0.95], p = 0.02; OR 0.70 [0.57, 0.85], p < 0.001 and OR 0.78 [0.63, 0.96], p = 0.02), respectively. However, SHBG was no longer associated with incident T2D after additional adjustment for TT (OR 0.92 [0.71, 1.17], p = 0.48; TT in incident T2D: OR 0.73 [0.57, 0.92], p = 0.01) and after separate adjustment for DHT (OR 0.83 [0.64, 1.08], p = 0.16; DHT in incident T2D: OR 0.83 [0.65, 1.05], p = 0.13). There was no observed effect of E2 in all models of incident T2D.
   In men, low TT, but not SHBG and other sex steroids, best predicts the development of T2D after adjustment for confounders.
C1 [Gyawali, Prabin; Martin, Sean A.; Heilbronn, Leonie K.; Vincent, Andrew D.; Wittert, Gary A.] Univ Adelaide, Adelaide Med Sch, Adelaide, SA, Australia.
   [Gyawali, Prabin; Martin, Sean A.; Vincent, Andrew D.; Wittert, Gary A.] Univ Adelaide, Freemasons Fdn Ctr Mens Hlth, Discipline Med, Adelaide, SA 5000, Australia.
   [Gyawali, Prabin; Martin, Sean A.; Heilbronn, Leonie K.; Vincent, Andrew D.; Taylor, Anne W.; Adams, Robert J. T.; Wittert, Gary A.] SAHMRI, Adelaide, SA, Australia.
   [Taylor, Anne W.] Univ Adelaide, Populat Res & Outcomes Studies, Adelaide, SA, Australia.
   [Adams, Robert J. T.] Univ Adelaide, Queen Elizabeth Hosp, Hlth Observ, Woodville, SA, Australia.
   [O'Loughlin, Peter D.] SA Pathol, Chem Pathol, Adelaide, SA, Australia.
C3 University of Adelaide; University of Adelaide; South Australian Health
   & Medical Research Institute (SAHMRI); University of Adelaide;
   University of Adelaide; SA Pathology
RP Wittert, GA (corresponding author), Univ Adelaide, Adelaide Med Sch, Adelaide, SA, Australia.; Wittert, GA (corresponding author), Univ Adelaide, Freemasons Fdn Ctr Mens Hlth, Discipline Med, Adelaide, SA 5000, Australia.; Wittert, GA (corresponding author), SAHMRI, Adelaide, SA, Australia.
EM gary.wittert@adelaide.edu.au
RI Adams, Robert/Z-3197-2019; wittert, gary/AAE-2398-2019; Taylor,
   Anne/F-5708-2010; Heilbronn, Leonie/H-1874-2013
OI Taylor, Anne/0000-0002-4422-7974; Wittert, Gary/0000-0001-6818-6065;
   Heilbronn, Leonie/0000-0003-2106-7303; Gyawali,
   Prabin/0000-0002-0855-3326
FU National Health and Medical Research Council of Australia (NHMRC)
   [627227]
FX This work was supported by the National Health and Medical Research
   Council of Australia (NHMRC Project Grant #627227, 2010-2012).
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NR 46
TC 42
Z9 45
U1 2
U2 8
PU SPRINGER-VERLAG ITALIA SRL
PI MILAN
PA VIA DECEMBRIO, 28, MILAN, 20137, ITALY
SN 0940-5429
EI 1432-5233
J9 ACTA DIABETOL
JI Acta Diabetol.
PD AUG
PY 2018
VL 55
IS 8
BP 861
EP 872
DI 10.1007/s00592-018-1163-6
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA GL9QL
UT WOS:000437670900012
PM 29845345
DA 2025-06-11
ER

PT J
AU van de Wiele, C
   Rimbu, A
   Belhocine, T
   de Spiegeleer, B
   Sathekge, M
   Maes, A
AF van de Wiele, Christophe
   Rimbu, Adriana
   Belhocine, Tarik
   de Spiegeleer, Bart
   Sathekge, Mike
   Maes, Alex
TI Reversible myocardial perfusion defects in patients not suffering from
   obstructive epicardial coronary artery disease as assessed by coronary
   angiography
SO QUARTERLY JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
LA English
DT Review
DE Myocardial perfusion imaging; Nuclear medicine; Coronary angiogra
ID BUNDLE-BRANCH-BLOCK; EMISSION COMPUTED-TOMOGRAPHY;
   SYSTEMIC-LUPUS-ERYTHEMATOSUS; ISCHEMIC-HEART-DISEASE; CARDIAC
   SYNDROME-X; COMPENSATORY ENLARGEMENT; STRESS ECHOCARDIOGRAPHY;
   MICROVASCULAR ANGINA; TL-201 SCINTIGRAPHY; VASOSPASTIC ANGINA
AB In approximately 10-30% of patients presenting with angina complaints, normal or non-obstructive coronary arteries are found on angiography. In this review paper, available literature on the underlying pathophysiological substrate explaining these discrepancies is reviewed. Both histological studies as well as studies using intravascular ultrasound e.g. the PROSPECT trial, show that epicardial coronary vessel significant lumen stenosis may be delayed until a plaque occupies 40% of the internal elastic lamina area. Limited available data suggest that these angiographically undetectable plaques are associated with an abnormal vasodilation capacity of the coronary circulation and may results in reversible perfusion defects on myocardial perfusion imaging (MPI). Organic non-atherosclerotic causes of epicardial coronary artery disease such as anomalous coronary arteries that course between the aorta and pulmonary artery, myocardial bridging and coronary vasospasm may also contribute to MPI results suggesting the presence of ischemia in the presence of normal coronary arteries on coronary angiography. Additional causes of reversible perfusion defects on MPI in the presence of a normal coronary angiogram are intraventricular conduction disturbances. The existence of reversible perfusion defects in the anteroseptal region in most of the patients suffering from left bundle branch block (LBBB) on MPI following physical exercise as stressor is well documented. As the observed reduced septal uptake of both 201Tl and 99mTc-sestamibi/tetrofosmin in LBBB reflects coronary autoregulation in response to lower oxygen demands, not surprisingly, dipyridamole which uniformly exploits flow reserve, has proven more accurate for the diagnosis of coronary artery disease (CAD) in patients suffering from LBBB. Although patients with a permanent ventricular pacemaker have a similar conduction abnormality as patients presenting with a LBBB, most of the defects found on MPI imaging in this patient population (in up to 78% of patients with a normal coronary angiogram that area continuously paced) are localized in the inferoposterior (71%), apical (50%) and inferoseptal (28%) wall; coronary flow velocities in the left anterior descending (LAD) and dominant coronary artery and coronary flow reserve are also significantly lower when compared to a control group. Contrary to what is seen in LBBB patients, dipyridamole stress does not significantly reduce the incidence of abnormalities found but limits the defects to the inferior wall. Furthermore, the frequency of abnormalities found on MPI increases over time with right ventricular outflow tract pacing. Previous histologic studies have shown that microvessel disease is often accompanied by a slow-flow phenomenon reflecting decreased resting flow velocity. Thus, not surprisingly, MPI reversible abnormalities in the presence of a normal coronary angiogram have been reported in a wide variety of diseases characterized by microvessel disease such as diabetes, systemic lupus erythematosus, Behcet's disease and metabolic syndrome. In these patients, low adiponectin and high lipoprotein(a) levels are found which are known to be associated with endothelial dysfunction, atherosclerosis and coronary artery disease. Furthermore, in these patients, limited available data suggest that reversible perfusion defects on MPI confer a significantly poorer prognosis both in terms of hard event rate (MI and cardiac death) and total event rate (MI, cardiac death or late revascularization).
   It is thus suggested that MPI could discriminate patients with a more severe prognosis. Finally, physical training in patients with primary microvascular angina appears to be associated with reduction of myocardial perfusion abnormalities.
C1 [van de Wiele, Christophe; Maes, Alex] AZ Groeninge, Dept Nucl Med, Reepkaai 4, B-8500 Kortrijk, Belgium.
   [van de Wiele, Christophe] Univ Ghent, Dept Radiol & Nucl Med, Ghent, Belgium.
   [van de Wiele, Christophe; Rimbu, Adriana] NUCLERIDIS, Ctr Andre Dutreix, Dunkerque, France.
   [Belhocine, Tarik] Western Univ, Biomed Imaging Res Ctr, London, ON, Canada.
   [de Spiegeleer, Bart] Univ Ghent, Dept Pharmaceut Anal, Ghent, Belgium.
   [Sathekge, Mike] Univ Pretoria, Dept Nucl Med, Pretoria, South Africa.
   [Maes, Alex] Univ Hosp Leuven, Dept Morphol & Med Imaging, Leuven, Belgium.
C3 Ghent University; Western University (University of Western Ontario);
   Ghent University; University of Pretoria; KU Leuven; University Hospital
   Leuven
RP van de Wiele, C (corresponding author), AZ Groeninge, Dept Nucl Med, Reepkaai 4, B-8500 Kortrijk, Belgium.
EM cvdwiele@hotmail.com
RI de Spiegeleer, Bart/A-2001-2008; Sathekge, Mike/AAJ-6466-2020
OI Sathekge, Mike/0000-0002-2806-0625
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NR 68
TC 4
Z9 4
U1 0
U2 3
PU EDIZIONI MINERVA MEDICA
PI TURIN
PA CORSO BRAMANTE 83-85 INT JOURNALS DEPT., 10126 TURIN, ITALY
SN 1824-4785
EI 1827-1936
J9 Q J NUCL MED MOL IM
JI Q. J. Nucl. Med. Mol. Imag.
PD SEP
PY 2018
VL 62
IS 3
BP 325
EP 335
DI 10.23736/S1824-4785.16.02875-2
PG 11
WC Radiology, Nuclear Medicine & Medical Imaging
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Radiology, Nuclear Medicine & Medical Imaging
GA GU4GH
UT WOS:000445240400012
PM 27007665
DA 2025-06-11
ER

PT J
AU Lalrinzuali, S
   Khushboo, M
   Dinata, R
   Bhanushree, B
   Nisa, N
   Bidanchi, RM
   Laskar, SA
   Manikandan, B
   Abinash, G
   Pori, B
   Roy, VK
   Gurusubramanian, G
AF Lalrinzuali, Sailo
   Khushboo, Maurya
   Dinata, Roy
   Bhanushree, Baishya
   Nisa, Nisekhoto
   Bidanchi, Rema Momin
   Laskar, Saeed-Ahmed
   Manikandan, Bose
   Abinash, Giri
   Pori, Buragohain
   Roy, Vikas Kumar
   Gurusubramanian, Guruswami
TI Long-term consumption of fermented pork fat-based diets differing in
   calorie, fat content, and fatty acid levels mediates oxidative stress,
   inflammation, redox imbalance, germ cell apoptosis, disruption of
   steroidogenesis, and testicular dysfunction in Wistar rats
SO ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
LA English
DT Article
DE Fermented pork fat; Oxidative stress; Inflammation; Apoptosis;
   Spermatogenesis; Steroidogenesis
ID METABOLISM
AB There is a dearth of experimental evidence available as to whether the consumption of fermented pork fat (FPF) food has any harmful effects on metabolism and reproduction due to its excessive calories, high fat content, and fatty acid methyl ester (FAME) levels. We hypothesized that exposure to a FPF-diet with excessive calories, a high fat content, and high FAME levels alters testicular physiology and metabolism, leading to permanent damage to the testicular system and its function. Thirteen-week-old male rats (n = 20) were assigned to a high-calorie, high-fat diet (FPF-H, fat-60%, 23 kJ/g), a moderate-calorie, moderate-fat diet (FPF-M, fat-30%, 17.5 kJ/g), a low-calorie and low-fat diet (FPF-L, fat-15%, 14.21 kJ/g) compared to the standard diet (Control, fat-11%, 12.56 kJ/g) orally for 90 days. GC-MS analysis of the three FPF-diets showed high quantities of saturated fatty acids (SFAs) and polyunsaturated fatty acids-omega 6 (PUFA-omega 6) and low levels of monounsaturated fatty acids (MUFAs) and polyunsaturated fatty acids-omega 3 (PUFA-omega 3) compared to the control diet. Consequently, the levels of serum FAMEs of the FPF-diet fed rats were significantly increased. In addition, a high level of n-6:n-3 PUFA towards PUFA-omega 6 was observed in the serum of FPF-diet fed rats due to the high content of linoleic, gamma-linolenic, and arachidonic acid. Long-term consumption of FPF-diets disturbed the anthropometrical, nutritional, physiological, and metabolic profiles. Furthermore, administration of FPF-diets generated metabolic syndrome (dyslipidemia, leptinemia, insulin resistance, obesity, hepato-renal disorder and function), increased the cardiovascular risk factors, and triggered serum and testis inflammatory markers (interleukin-1 up arrow, interleukin-6 up arrow, interleukin-10 down arrow, leukotriene B4 up arrow, prostaglandin up arrow, nitric oxide up arrow, myeloperoxidase up arrow, lactate dehydrogenase up arrow, and tumor necrosis factor-alpha up arrow). Activated testis oxidative stress (conjugated dienes up arrow, lipid hydroperoxides up arrow, malondialdehyde up arrow, protein carbonyl up arrow, and fragmented DNA up arrow) and depleted antioxidant reserve (catalase down arrow, superoxide dismutase down arrow, glutathione S-transferase down arrow, reduced glutathione down arrow, glutathione disulfide up arrow, and GSH:GSSG ratio down arrow) were observed in FPF-diet fed rats. Disrupted testis histoarchitecture, progressive deterioration of spermatogenesis, poor sperm quality and functional indices, significant alterations in the reproductive hormones (serum and testis testosterone down arrow, serum estradiol up arrow, serum luteinizing hormone down arrow, and follicle-stimulating hormone up arrow), were noted in rats fed with FPF diets than in the control diet. Severe steroidogenic impairment (steroidogenic acute regulatory protein, StAR down arrow; 3 beta-hydroxysteroid dehydrogenase, 3 beta-HSD down arrow; and luteinizing hormone receptor, LHR down arrow), deficiency in germ cells proliferation (proliferating cell nuclear antigen, PCNA down arrow), and abnormally enhanced testicular germ cell apoptosis (terminal deoxynucleotidyl transferase dUTP nick end labeling, TUNEL assay up arrow; B-cell lymphoma-2, BCL-2 down arrow; Bcl-2-associated X protein, BAX up arrow; and BAX/BCL-2 ratio up arrow) were remarked in the FPF-diet administered rats in comparison with the control diet.
   In conclusion, the long-term feeding of an FPF-diet with excessive calories, a high fat content, and high FAME levels induced oxidative stress, inflammation, and apoptosis, resulting in metabolic syndrome and hampering male reproductive system and functions. Therefore, the adoption of FPF diets correlates with irreversible changes in testis metabolism, steroidogenesis, germ cell proliferation, and apoptosis, which are related to permanent damage to the testicular system and function later in life.
C1 [Lalrinzuali, Sailo; Khushboo, Maurya; Dinata, Roy; Bhanushree, Baishya; Nisa, Nisekhoto; Bidanchi, Rema Momin; Laskar, Saeed-Ahmed; Manikandan, Bose; Abinash, Giri; Pori, Buragohain; Roy, Vikas Kumar; Gurusubramanian, Guruswami] Mizoram Univ, Dept Zool, Aizawl 796004, Mizoram, India.
C3 Mizoram University
RP Gurusubramanian, G (corresponding author), Mizoram Univ, Dept Zool, Aizawl 796004, Mizoram, India.
EM gurus64@yahoo.com
RI Roy, Vikas/O-5995-2019; Baishya, Bhanushree/GLT-1386-2022; Maurya,
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OI Bose, Manikandan/0000-0003-2996-0729; MOMIN,
   BIDANCHI/0000-0001-7231-9123
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NR 39
TC 6
Z9 6
U1 1
U2 7
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0944-1344
EI 1614-7499
J9 ENVIRON SCI POLLUT R
JI Environ. Sci. Pollut. Res.
PD APR
PY 2023
VL 30
IS 18
BP 52446
EP 52471
DI 10.1007/s11356-023-26018-0
EA FEB 2023
PG 26
WC Environmental Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology
GA I5SQ0
UT WOS:000940264200005
PM 36840878
DA 2025-06-11
ER

PT J
AU Jacob, L
   Stubbs, B
   Koyanagi, A
AF Jacob, Louis
   Stubbs, Brendon
   Koyanagi, Ai
TI Consumption of carbonated soft drinks and suicide attempts among 105,061
   adolescents aged 12-15 years from 6 high-income, 22 middle-income, and 4
   low-income countries
SO CLINICAL NUTRITION
LA English
DT Article
DE Carbonated soft drinks; Suicide attempts; Adolescents; Epidemiology
ID SUGAR-SWEETENED BEVERAGES; RISK-FACTORS; CARDIOVASCULAR-DISEASE;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; PHYSICAL-ACTIVITY; OXIDATIVE
   STRESS; BEHAVIOR; PREVALENCE; DEPRESSION
AB Background & aims: Multinational studies on the relationship between consumption of sugar-sweetened beverages and suicidal behavior in youths are lacking. Thus, the goal of this study was to investigate the association between consumption of carbonated soft drinks and suicide attempts among adolescents from 6 high-income, 22 middle-income and 4 low-income countries.
   Methods: Cross-sectional data from the Global school-based student health survey (GSHS) were analyzed. Data on past 12-month suicide attempts and past 30-day carbonated soft drink consumption (number of times per day) were collected. Multivariable logistic regression and meta-analysis were conducted to assess associations.
   Results: There were 105,061 adolescents (49.0% females) aged 12-15 years included in the analysis. The overall prevalence of suicide attempts and consumption of carbonated soft drinks >= 3 times/day were 10.2% and 10.7%, respectively. After adjustment for potential confounders (i.e., sex, age, food insecurity, alcohol consumption, smoking, physical activity, obesity, fruit and vegetable consumption, fast food consumption, country), compared to those who did not consume carbonated soft drinks, those who consumed 3 and >= 4 times/day were 1.36 (95%CI = 1.07-1.72) and 1.43 (95%CI = 1.14-1.80) times more likely to have reported an attempted suicide in the past 12 months, respectively. Country-wise analyses showed that consumption of carbonated soft drinks >= 3 times/day (vs. <3 times/day) was associated with higher odds for suicide attempts (i.e., OR>1) in 22 of the 32 included countries with the pooled OR (95% CI) based on a meta-analysis being 1.20 (1.12-1.28; I-2 = 28.6%).
   Conclusions: Our data indicate that there is a positive association between consumption of carbonated soft drinks and suicide attempts in the past 12 months. Further studies should confirm/refute our findings and investigate the potential underlying mechanisms. (C) 2019 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.
C1 [Jacob, Louis] Univ Versailles St Quentin En Yvelines, Fac Med, 2 Ave Source Bievre, F-78180 Montigny Le Bretonneux, France.
   [Stubbs, Brendon] South London & Maudsley NHS Fdn Trust, Physiotherapy Dept, Denmark Hill, London, England.
   [Stubbs, Brendon] Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Psychol Med, London, England.
   [Stubbs, Brendon] Anglia Ruskin Univ, Fac Hlth Social Care & Educ, Chelmsford, England.
   [Koyanagi, Ai] Univ Barcelona, Fundacio St Joan de Deu, CIBERSAM, Res & Dev Unit,Parc Sanitari St Joan de Deu, Dr Antoni Pujadas 42, Barcelona 08830, Spain.
   [Koyanagi, Ai] ICREA, Pg Lluis Companys 23, Barcelona, Spain.
C3 Universite Paris Saclay; University of London; King's College London;
   Anglia Ruskin University; CIBER - Centro de Investigacion Biomedica en
   Red; CIBERSAM; University of Barcelona; ICREA
RP Jacob, L (corresponding author), Univ Versailles St Quentin En Yvelines, Fac Med, 2 Ave Source Bievre, F-78180 Montigny Le Bretonneux, France.
EM louis.jacob.contacts@gmail.com
RI Stubbs, Brendon/X-1904-2018; Jacob, Louis/AAL-3956-2020; Koyanagi,
   Ai/D-3833-2018; Stubbs, Brendon/C-5696-2015
OI Koyanagi, Ai/0000-0002-9565-5004; Stubbs, Brendon/0000-0001-7387-3791;
   Jacob, Louis/0000-0003-1071-1239
FU Department of Health [ICA-CL-2017-03-001] Funding Source: Medline
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NR 49
TC 32
Z9 34
U1 3
U2 19
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0261-5614
EI 1532-1983
J9 CLIN NUTR
JI Clin. Nutr.
PD MAR
PY 2020
VL 39
IS 3
BP 886
EP 892
DI 10.1016/j.clnu.2019.03.028
PG 7
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nutrition & Dietetics
GA KW9NG
UT WOS:000521509800027
PM 31000339
OA Bronze
DA 2025-06-11
ER

PT J
AU Wong, EML
   Leung, DYP
   Lam, SC
   Suen, LKP
   Tang, ACY
   Ko, SY
   Leung, AYM
AF Wong, Eliza M. L.
   Leung, Doris Y. P.
   Lam, Simon C.
   Suen, Lorna K. P.
   Tang, Anson C. Y.
   Ko, Shuk Y.
   Leung, Angela Y. M.
TI Effect of a Nurse-Led Support Program Using Mobile Application Versus
   Nurse Phone Advice on Patients at Risk of Coronary Artery Disease: A
   Randomized Controlled Trial
SO WORLDVIEWS ON EVIDENCE-BASED NURSING
LA English
DT Article
DE at risk; community program; coronary artery disease; mobile application;
   nurse; phone advice; randomized controlled trial
ID STYLE INTERVENTION PROGRAM; PHYSICAL-ACTIVITY; SECONDARY PREVENTION;
   METABOLIC SYNDROME; HEART-DISEASE; LIFE; ADULTS; DEPRESSION; OUTCOMES
AB BackgroundCoronary artery disease (CAD) is a major health problem of atherosclerotic cardiovascular (CV) disease and early intervention is regarded important. Given the proven effect of a lifestyle intervention with nursing telephone counselling and mHealth use in health care, yet the comparisons of both support are lacking, this study is proposed.ObjectivesThis study aimed to compare the effects of a coronary artery disease (CAD) support program using a mobile application versus nurse phone advice on exercise amount and physical and psychological outcomes for clients at risk of CAD.MethodsA prospective randomized controlled trial was conducted. Ethical approval was obtained. Two-hundred and twenty-six clients were screened, and a total of 168 clients who were at risk of CAD and routinely used smartphones were randomized into the app support group (App group) or the nurse phone advice (NPA) group. Although all participants received the same health talk delivered by a cardiac nurse at the community center, the App group received additional CAD app support, whereas the NPA group received nurse phone advice for 20 min monthly. The app content comprised (1) CAD knowledge in 10 modules, (2) individual exercise records with their own goals and health measures, and (3) a chest pain action list. The intervention lasted for 3 months. Health outcome data were collected at baseline (T0) and after 1 (T1) and 3 (T2) months. The outcomes were the total amount of exercise (primary outcome), self-efficacy in illness management, perceived stress, and CAD risk profile (body weight, body mass index, and lipid concentration). Generalized estimating equation models were used to assess differential changes in all outcomes within 3 months.ResultsThe attrition rates at 3 months were 3.49% and 9.30% for the App and NPA groups, respectively. The App support group was superior to the NPA group in significantly increasing total exercise amount and reducing body weight, waist circumference, triglycerides, and increased self-efficacy in illness management.Linking Evidence to ActionThe result provides further insights of app development to support health promotion programs for community-dwelling adults at risk of CAD.
C1 [Wong, Eliza M. L.; Lam, Simon C.; Suen, Lorna K. P.; Tang, Anson C. Y.] Tung Wah Coll, Sch Nursing, Hong Kong, Peoples R China.
   [Leung, Doris Y. P.; Leung, Angela Y. M.] Hong Kong Polytech Univ, Sch Nursing, Hong Kong, Peoples R China.
   [Ko, Shuk Y.] Tuen Mun Hosp, Accid & Emergency Dept, Hong Kong, Peoples R China.
C3 Tung Wah College; Hong Kong Polytechnic University; Tuen Mun Hospital
RP Wong, EML (corresponding author), Tung Wah Coll, Sch Nursing, Hong Kong, Peoples R China.
EM elizawong@twc.edu.hk
RI Wong, Eliza/AAH-6193-2020; Leung, Yin/C-4492-2009; Leung,
   Angela/X-4415-2019; Lam, Simon/H-7361-2019; Tang, Anson/ABE-5475-2020;
   Suen, Lorna/F-5077-2014
FU Donation Grant by Nam Kee Noodle Foundation Ltd; Mr. Ngai and Nam Kee
   Noodle Foundations - Donation Grant by Nam Kee Noodle Foundations Ltd.
   [NAMKEE2021-04-76, R-ZH4E]; UGC Matching Grant
FX The authors would like to thank all participants, involved community
   centers for their participation in the study. Thank you very much for
   Dr. HL Tam to conduct subgroup and further analysis, Ms. Alice SP Cheung
   and Chelsia Cheung for data collection. Lastly, sincere thanks for Mr.
   Ngai and Nam Kee Noodle Foundations to support this research. This study
   was funded by Donation Grant by Nam Kee Noodle Foundations Ltd. and UGC
   Matching Grant (NAMKEE2021-04-76 and R-ZH4E).
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NR 32
TC 0
Z9 0
U1 4
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1545-102X
EI 1741-6787
J9 WORLDV EVID-BASED NU
JI Worldviews Evid.-Based Nurs.
PD FEB
PY 2025
VL 22
IS 1
AR e12765
DI 10.1111/wvn.12765
PG 12
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA S2C7L
UT WOS:001396375600001
PM 39791254
DA 2025-06-11
ER

PT J
AU Li, ZW
   Zhao, HM
   Wang, J
AF Li, Zhiwei
   Zhao, Hongmei
   Wang, Jing
TI Metabolism and Chronic Inflammation: The Links Between Chronic Heart
   Failure and Comorbidities
SO FRONTIERS IN CARDIOVASCULAR MEDICINE
LA English
DT Review
DE heart failure; comorbidities; metabolism; chronic inflammation; reactive
   oxygen species; mitochondria
ID OBSTRUCTIVE PULMONARY-DISEASE; PRESERVED EJECTION FRACTION; BODY-MASS
   INDEX; MYOCARDIAL SUBSTRATE METABOLISM; BRAIN NATRIURETIC PEPTIDE;
   GLUCOSE-LOWERING AGENTS; CHAIN AMINO-ACIDS; ATRIAL-FIBRILLATION;
   MITOCHONDRIAL DYSFUNCTION; CARDIOVASCULAR OUTCOMES
AB Heart failure (HF) patients often suffer from multiple comorbidities, such as diabetes, atrial fibrillation, depression, chronic obstructive pulmonary disease, and chronic kidney disease. The coexistance of comorbidities usually leads to multi morbidity and poor prognosis. Treatments for HF patients with multi morbidity are still an unmet clinical need, and finding an effective therapy strategy is of great value. HF can lead to comorbidity, and in return, comorbidity may promote the progression of HF, creating a vicious cycle. This reciprocal correlation indicates there may be some common causes and biological mechanisms. Metabolism remodeling and chronic inflammation play a vital role in the pathophysiological processes of HF and comorbidities, indicating metabolism and inflammation may be the links between HF and comorbidities. In this review, we comprehensively discuss the major underlying mechanisms and therapeutic implications for comorbidities of HF. We first summarize the potential role of metabolism and inflammation in HF. Then, we give an overview of the linkage between common comorbidities and HF, from the perspective of epidemiological evidence to the underlying metabolism and inflammation mechanisms. Moreover, with the help of bioinformatics, we summarize the shared risk factors, signal pathways, and therapeutic targets between HF and comorbidities. Metabolic syndrome, aging, deleterious lifestyles (sedentary behavior, poor dietary patterns, smoking, etc.), and other risk factors common to HF and comorbidities are all associated with common mechanisms. Impaired mitochondrial biogenesis, autophagy, insulin resistance, and oxidative stress, are among the major mechanisms of both HF and comorbidities. Gene enrichment analysis showed the PI3K/AKT pathway may probably play a central role in multi morbidity. Additionally, drug targets common to HF and several common comorbidities were found by network analysis. Such analysis has already been instrumental in drug repurposing to treat HF and comorbidity. And the result suggests sodium-glucose transporter-2 (SGLT-2) inhibitors, IL-1 beta inhibitors, and metformin may be promising drugs for repurposing to treat multi morbidity. We propose that targeting the metabolic and inflammatory pathways that are common to HF and comorbidities may provide a promising therapeutic strategy.
C1 [Li, Zhiwei; Zhao, Hongmei; Wang, Jing] Chinese Acad Med Sci, Peking Union Med Coll, Sch Basic Med,Dept Pathophysiol, State Key Lab Med Mol Biol,Inst Basic Med, Beijing, Peoples R China.
C3 Chinese Academy of Medical Sciences - Peking Union Medical College;
   Peking Union Medical College
RP Zhao, HM; Wang, J (corresponding author), Chinese Acad Med Sci, Peking Union Med Coll, Sch Basic Med,Dept Pathophysiol, State Key Lab Med Mol Biol,Inst Basic Med, Beijing, Peoples R China.
EM pumczhaohm@sina.com; wangjing@ibms.pumc.edu.cn
OI Li, Zhiwei/0000-0001-8031-6547
FU National Key Research and Development Program of China [2018YFC1315103,
   2019YFA0801700, 2019YFA0801800]; National Natural Science Foundation of
   China [81800359, 81622008, 81470579]; Chinese Academy of Medical
   Sciences Innovation Fund for Medical Sciences [2016-I2M-1-006]; Peking
   Union Medical College Youth Fund/the Fundamental Research Funds for the
   Central University [3332016048]; Thousand Young Talents Program of China
FX This study was financially supported by the National Key Research and
   Development Program of China Grants 2018YFC1315103 (to HZ),
   2019YFA0801700, 2019YFA0801800 (to JW); National Natural Science
   Foundation of China Grants 81800359 (to HZ) and 81622008, 81470579 (to
   JW); Chinese Academy of Medical Sciences Innovation Fund for Medical
   Sciences (2016-I2M-1-006) (to JW); Peking Union Medical College Youth
   Fund/the Fundamental Research Funds for the Central University
   (3332016048) (to HZ); and Thousand Young Talents Program of China (to
   JW).
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NR 227
TC 54
Z9 59
U1 2
U2 38
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2297-055X
J9 FRONT CARDIOVASC MED
JI Front. Cardiovasc. Med.
PD MAY 5
PY 2021
VL 8
AR 650278
DI 10.3389/fcvm.2021.650278
PG 18
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA SE0JH
UT WOS:000651760400001
PM 34026868
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU van Dammen, L
   Bush, NR
   de Rooij, S
   Mol, B
   Mutsaerts, M
   van Oers, A
   Groen, H
   Hoek, A
   Roseboom, T
AF van Dammen, Lotte
   Bush, Nicole R.
   de Rooij, Susanne
   Mol, Ben Willem
   Mutsaerts, Meike
   van Oers, Anne
   Groen, Henk
   Hoek, Annemieke
   Roseboom, Tessa
TI A lifestyle intervention randomized controlled trial in obese women with
   infertility improved body composition among those who experienced
   childhood adversity
SO STRESS AND HEALTH
LA English
DT Article
DE childhood adversity; effectiveness; lifestyle intervention; obesity
ID GENETIC DIFFERENTIAL SUSCEPTIBILITY; CARDIOVASCULAR-DISEASE;
   WEIGHT-LOSS; DISORDER; STRESS; ADULTS; RESILIENCE; DEPRESSION;
   MODERATION; IMPACT
AB Previous research indicates that tailoring lifestyle interventions to participant characteristics optimizes intervention effectiveness. Our objective was to assess whether the effects of a preconception lifestyle intervention in obese infertile women depended on women's exposure to adversity in childhood. A follow-up of a preconception lifestyle intervention randomized controlled trial (the LIFEstyle study) was conducted in the Netherlands among 577 infertile women (age 18-39 years) with a body mass index (BMI) >= 29 kg/m(2)at time of randomization;N= 110 (19%) consented to the follow-up assessment, 6 years later. A 6-month preconception lifestyle intervention aimed weight loss through improving diet and increasing physical activity. The control group received care as usual. Outcome measures included weight, BMI, waist and hip circumference, body fat percentage, blood pressure and metabolic syndrome. The potential moderator, childhood adversity, was assessed with the Life Events Checklist-5 questionnaire. Among the 110 women in our follow-up study,n= 65 (59%) reported no childhood adverse events,n= 28 (25.5%) reported 1 type of childhood adverse events andn= 17 (15.5%) reported >= 2 types of childhood adverse events. Regression models showed significant interactions between childhood adversity and effects of lifestyle intervention at the 6-year follow-up. Among women who experienced childhood adversity, the intervention significantly reduced weight (-10.0 [95% CI -18.5 to -1.5] kg,p= 0.02), BMI (-3.2 [-6.1 to -0.2] kg/m(2),p= 0.04) and body fat percentage (-4.5 [95% CI -7.2 to -1.9]p< 0.01). Among women without childhood adversity, the intervention did not affect these outcomes (2.7 [-3.9 to 9.4] kg,p= 0.42), (0.9 [-1.4 to 3.3] kg/m(2),p= 0.42) and (1.7 [95% CI -0.3 to 3.7]p= 0.10), respectively. Having a history of childhood adversity modified the effect of a preconception lifestyle intervention on women's body composition. If replicated, it may be important to consider childhood adversity as a determinant of lifestyle intervention effectiveness.
C1 [van Dammen, Lotte] Iowa State Univ, Dept Human Dev & Family Studies, Ames, IA 50011 USA.
   [van Dammen, Lotte; Mutsaerts, Meike; van Oers, Anne; Hoek, Annemieke] Univ Groningen, Univ Med Ctr Groningen, Dept Obstet & Gynaecol, Groningen, Netherlands.
   [van Dammen, Lotte; Groen, Henk] Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, Groningen, Netherlands.
   [Bush, Nicole R.] Univ Calif San Francisco, Ctr Hlth & Community, Div Dev Med, Dept Psychiat, San Francisco, CA USA.
   [Bush, Nicole R.] Univ Calif San Francisco, Ctr Hlth & Community, Div Dev Med, Dept Pediat, San Francisco, CA USA.
   [de Rooij, Susanne; Roseboom, Tessa] Amsterdam UMC, Locat AMC, Dept Clin Epidemiol Biostat & Bioinformat, Amsterdam, Netherlands.
   [Mol, Ben Willem] Monash Univ, Dept Obstet & Gynaecol, Clayton, Vic, Australia.
   [van Oers, Anne] Med Spectrum Twente, Dept Obstet & Gynaecol, Enschede, Netherlands.
   [Roseboom, Tessa] Univ Amsterdam, Dept Obstet & Gynaecol, Amsterdam UMC, Amsterdam, Netherlands.
C3 Iowa State University; University of Groningen; University of Groningen;
   University of California System; University of California San Francisco;
   University of California System; University of California San Francisco;
   University of Amsterdam; Monash University; Medical Spectrum Twente;
   University of Amsterdam
RP van Dammen, L (corresponding author), Iowa State Univ, Dept Human Dev & Family Studies, Ames, IA 50011 USA.
EM lotte@iastate.edu
RI Bush, Nicole/AAH-4935-2020; Mol, Ben/I-4526-2012; van Dammen,
   Lotte/ABD-4674-2021; Groen, Henk/B-2163-2013
OI Groen, Henk/0000-0002-6629-318X; de Rooij, Susanne
   Rosalie/0000-0001-7382-5749; Mol, Ben Willem/0000-0001-8337-550X; van
   Dammen, Lotte/0000-0001-8012-8263; Roseboom, Tessa/0000-0003-0564-5994
FU Hartstichting [2013T085]; ZonMw [50-50110-96-518]; European Commission
   [633595]
FX Hartstichting, Grant/Award Number: 2013T085; ZonMw, Grant/Award Number:
   50-50110-96-518; European Commission, Grant/Award Number: 633595
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NR 42
TC 6
Z9 6
U1 1
U2 16
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1532-3005
EI 1532-2998
J9 STRESS HEALTH
JI Stress Health
PD FEB
PY 2021
VL 37
IS 1
BP 93
EP 102
DI 10.1002/smi.2976
EA AUG 2020
PG 10
WC Psychology, Applied; Psychiatry; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA QL8II
UT WOS:000560025800001
PM 32761731
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Albrahim, T
   Alonazi, MA
AF Albrahim, Tarfa
   Alonazi, Mona A.
TI Lycopene corrects metabolic syndrome and liver injury induced by high
   fat diet in obese rats through antioxidant, anti-inflammatory,
   antifibrotic pathways
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Article
DE Oxidative stress; Lycopene; Dyslipidemia; Inflammation; PPAR-gamma;
   Fibrosis
ID OXIDATIVE STRESS; INSULIN-RESISTANCE; PPAR-GAMMA; INFLAMMATION;
   SUPPLEMENTATION; OVERWEIGHT; INFARCTION; FRUCTOSE; DISEASE; ACID
AB Obesity is a global epidemic disease that is closely associated with various health problems as Diabetes mellitus, cardiovascular, and metabolic disorders. Lycopene (LYC), a red-colored carotenoid, has demonstrated various promising therapeutic effects. Hence, the potential of LYC was studied against high fat diet (HFD)-induced obesity and metabolic disturbances in rats. Animals fed on HFD and orally supplemented with LYC (25 and 50 mg/kg) or simvastatin (10 mg/kg) every day for 3 months. The results revealed that long-term consumption of HFD significantly increased weight gain, liver weight, cholesterol, triglycerides (TG), apolipoprotein-B (Apo-B), low-density lipoprotein-cholesterol (LDL-c) levels, as well as decreasing the high-density lipoprotein-cholesterol (HDL-c) levels. Moreover, high blood glucose and insulin levels accompanied by low peroxisome proliferator activated receptor gamma (PPAR-gamma) were recorded in HFD group. Further, HFD rats displayed lower levels of antioxidant biomarkers (SOD, CAT, GPx, GR and GSH), in addition to higher levels of MDA, NO and inflammatory mediators (IL-1 beta, TNF-alpha, and MPO). Marked increases were observed in atherogenic index, lactate dehydrogenase and creatine kinase together with fibrosis markers (TGF-beta 1 and alpha-SMA) in rats fed on HFD. Comparing to model group, LYC was able to effectively reverse HFD-mediated alterations at dose dependent manner. Altogether, dietary supplementation of LYC successfully reversed HFD-induced alterations through its antioxidant, anti-inflammatory, and anti-fibrotic properties. Hence, LYC displayed a therapeutic potential to manage obesity and its associated pathologies.
C1 [Albrahim, Tarfa] Princess Nourah Bint Abdulrahman Univ, Coll Hlth & Rehabil Sci, Dept Hlth Sci Clin Nutr, Riyadh, Saudi Arabia.
   [Alonazi, Mona A.] King Saud Univ, Coll Sci, Dept Biochem, Riyadh, Saudi Arabia.
C3 Princess Nourah bint Abdulrahman University; King Saud University
RP Albrahim, T (corresponding author), Princess Nourah Bint Abdulrahman Univ, Coll Hlth & Rehabil Sci, Dept Hlth Sci Clin Nutr, Riyadh, Saudi Arabia.
EM tarfa.ibrahim21@gmail.com
RI A, Mona/AAF-6911-2019
OI Albrahim, Tarfa/0000-0003-4360-8115
FU Deanship of Scientific Research at Princess Nourah Bint Abdulrahman
   University through the Fast-track Research Funding Program
FX This research was funded by Deanship of Scientific Research at Princess
   Nourah Bint Abdulrahman University through the Fast-track Research
   Funding Program.
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NR 68
TC 50
Z9 52
U1 0
U2 24
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD SEP
PY 2021
VL 141
AR 111831
DI 10.1016/j.biopha.2021.111831
EA JUL 2021
PG 9
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA UO6LS
UT WOS:000694805400004
PM 34237596
OA gold
DA 2025-06-11
ER

PT J
AU Shawki, HA
   Elzehery, R
   Shahin, M
   Abo-hashem, EM
   Youssef, MM
AF Shawki, Hadeel Ahmed
   Elzehery, Rasha
   Shahin, Maha
   Abo-hashem, Ekbal M.
   Youssef, Magdy M.
TI Evaluation of some oxidative markers in diabetes and diabetic
   retinopathy
SO DIABETOLOGY INTERNATIONAL
LA English
DT Article
DE Uric acid; Malondialdehyde; Bilirubin; Diabetes; Diabetic retinopathy
ID TOTAL BILIRUBIN CONCENTRATION; METABOLIC SYNDROME; URIC-ACID;
   RISK-FACTORS; STRESS; SERUM; MELLITUS; INFLAMMATION; ASSOCIATION;
   PREVALENCE
AB Aims Diabetes mellitus and diabetic retinopathy (DR) are major public health concerns globally. Oxidative stress plays a central role in the pathogenesis of diabetes and DR. The aim of this study was to investigate the association of malondialdehyde, uric acid and bilirubin with diabetes and diabetic retinopathy development. Methods This study was conducted on 110 diabetics (with and without retinopathy). Beside 40 healthy individuals as a control group. The level of three markers (malondialdehyde, uric acid and bilirubin) was estimated in the studied groups. Receiver operating characteristic analysis and a logistic regression model was performed. Results The present study revealed significantly higher uric acid and malondialdehyde levels, while bilirubin showed significantly lower levels in diabetics compared to control and similarly in diabetic retinopathy compared to those without DR. Furthermore, combination of the three markers increased the accuracy and effect size for differentiation between diabetes with and without DR. In addition, higher levels of uric acid and malondialdehyde were associated with risk of diabetes and DR development. Conclusion This study concluded that higher levels of uric acid and malondialdehyde were associated with increase in the risk of diabetes and DR development, while bilirubin wasn't associated with decreasing the risk of diabetes or DR. However, the combination of malondialdehyde, uric acid and bilirubin may be a valuable addition to the current options for the prognosis of DR. In addition, malondialdehyde may be independent predictor of diabetes and DR as well as uric acid may be used as independent biomarker to predict the risk of DR.
C1 [Shawki, Hadeel Ahmed; Youssef, Magdy M.] Mansoura Univ, Fac Sci, Chem Dept, Div Biochem, Mansoura, Egypt.
   [Elzehery, Rasha; Abo-hashem, Ekbal M.] Mansoura Univ, Fac Med, Dept Clin Pathol, Mansoura, Egypt.
   [Shawki, Hadeel Ahmed; Shahin, Maha] Mansoura Univ, Mansoura Ophthalm Ctr, Mansoura, Egypt.
C3 Egyptian Knowledge Bank (EKB); Mansoura University; Egyptian Knowledge
   Bank (EKB); Mansoura University; Egyptian Knowledge Bank (EKB); Mansoura
   University; General Organization of Teaching Hospitals & Institutes
   (GOTHI); Research Institute of Ophthalmology (RIO)
RP Shawki, HA (corresponding author), Mansoura Univ, Fac Sci, Chem Dept, Div Biochem, Mansoura, Egypt.; Shawki, HA (corresponding author), Mansoura Univ, Mansoura Ophthalm Ctr, Mansoura, Egypt.
EM biolab_msd@yahoo.com
RI ELzeheiry, Rasha/AGY-3241-2022; Yoyssef, Magdy/O-6289-2018; Ahmed
   Shawki, hadeel/LKK-2986-2024; Shahin, Maha/GOJ-7242-2022
OI Youssef, Magdy M./0000-0003-4205-5379; Ahmed Shawki,
   hadeel/0000-0002-3669-9189
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NR 67
TC 8
Z9 9
U1 0
U2 11
PU SPRINGER JAPAN KK
PI TOKYO
PA SHIROYAMA TRUST TOWER 5F, 4-3-1 TORANOMON, MINATO-KU, TOKYO, 105-6005,
   JAPAN
SN 2190-1678
EI 2190-1686
J9 DIABETOL INT
JI Diabetol. Int.
PD JAN
PY 2021
VL 12
IS 1
BP 108
EP 117
DI 10.1007/s13340-020-00450-w
EA JUN 2020
PG 10
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA PP6KJ
UT WOS:000544257200002
PM 33479586
OA Green Published
DA 2025-06-11
ER

PT J
AU Zhang, YJ
   Liu, HW
   He, J
   Xu, KL
   Bai, H
   Wang, Y
   Zhang, F
   Zhang, JX
   Cheng, L
   Fan, P
AF Zhang, Yujin
   Liu, Hongwei
   He, Jin
   Xu, Kelei
   Bai, Huai
   Wang, Ying
   Zhang, Feng
   Zhang, Jinxia
   Cheng, Li
   Fan, Ping
TI Lactonase activity and status of paraoxonase 1 in Chinese women with
   polycystic ovarian syndrome
SO EUROPEAN JOURNAL OF ENDOCRINOLOGY
LA English
DT Article
ID LOW-DENSITY-LIPOPROTEIN; OXIDATIVE STRESS; METABOLIC SYNDROME; PON1
   ACTIVITY; RISK-FACTOR; GENE; POLYMORPHISMS; ASSOCIATION; INHIBITION;
   HYPERANDROGENISM
AB Objective: To study the relationship between the lactonase activities and status of paraoxonase 1 (PON1) and its association with the PON1 genetic polymorphisms in women with polycystic ovarian syndrome (PCOS).
   Design: A case-control study.
   Methods: A total of 455 PCOS patients and 441 control women were included in this study. The lactonase activities and concentrations of PON1 were assayed using 5-thiobutyl butyrolactone (TBBL) and 7-O-diethylphosphoryl-3-cyano-4-methyl-7- hydroxycoumarin (DEPCyMC) respectively. A normalized lactonase activity (NLA) was estimated based on the ratio of TBBLase: DEPCyMCase activity. The PON1 genotypes, serum malondialdehyde (MDA) levels and total antioxidant capacity were analyzed.
   Results: The lactonase activities and levels of PON1 were higher in PCOS patients than in the control women. However, the NLA did not significantly differ between groups. The -108C -> T variation of the PON1 gene showed decreased lactonase activities and levels of PON1 in a genotype-dependent manner (CC > CT > TT); the 192Q -> R variation of the PON1 gene showed increased PON1 lactonase activities and NLA; and the 55L -> M variation of the PON1 gene showed decreased lactonase activities and levels of PON1 but an increased NLA. A multivariable regression analysis showed that the -108C/T, 192Q/R, and 55L/M variations of the PON1 gene, serum apolipoprotein A1, and MDA levels were significant predictors of PON1 lactonase activity, PON1 level, and NLA.
   Conclusions: The serum lactonase activities and concentrations of PON1 are increased in PCOS patients. The increased oxidative stress and the -108C/T, 192Q/R, and 55L/M genetic polymorphisms of PON1 may be associated with these changes.
C1 [Zhang, Yujin; Liu, Hongwei; Wang, Ying; Zhang, Feng] Sichuan Univ, West China Univ Hosp 2, Dept Obstet & Gynecol, Chengdu 610041, Sichuan, Peoples R China.
   [He, Jin; Xu, Kelei; Cheng, Li] Sichuan Univ, West China Sch Pharm, Chengdu 610041, Sichuan, Peoples R China.
   [Bai, Huai; Zhang, Jinxia; Fan, Ping] Sichuan Univ, West China Univ Hosp 2, Lab Genet Dis & Perinatal Med, Chengdu 610041, Sichuan, Peoples R China.
   [Bai, Huai; Zhang, Jinxia; Fan, Ping] Sichuan Univ, West China Univ Hosp 2, Key Lab Birth Defects & Related Dis Women & Child, Minist Educ, Chengdu 610041, Sichuan, Peoples R China.
C3 Sichuan University; Sichuan University; Sichuan University; Sichuan
   University; Ministry of Education - China
RP Fan, P (corresponding author), Sichuan Univ, West China Univ Hosp 2, Lab Genet Dis & Perinatal Med, Chengdu 610041, Sichuan, Peoples R China.
EM fanping15@scu.edu.cn
RI Zhang, Zhiqiang/GLS-9612-2022
FU Chinese National Natural Science Foundation [81070463, 81370681];
   Program for Changjiang Scholars and Innovative Research Team in
   University, Ministry of Education [IRT0935]
FX This work was supported by the Chinese National Natural Science
   Foundation (grant numbers 81070463 and 81370681) and the Program for
   Changjiang Scholars and Innovative Research Team in University, Ministry
   of Education (grant number IRT0935).
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NR 60
TC 25
Z9 25
U1 0
U2 11
PU BIOSCIENTIFICA LTD
PI BRISTOL
PA EURO HOUSE, 22 APEX COURT WOODLANDS, BRADLEY STOKE, BRISTOL BS32 4JT,
   ENGLAND
SN 0804-4643
EI 1479-683X
J9 EUR J ENDOCRINOL
JI Eur. J. Endocrinol.
PD APR
PY 2015
VL 172
IS 4
BP 391
EP 402
DI 10.1530/EJE-14-0863
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA CC4TO
UT WOS:000350346900013
PM 25575948
OA Bronze
DA 2025-06-11
ER

PT J
AU Forte, V
   Pandey, A
   Abdelmessih, R
   Forte, G
   Whaley-Connell, A
   Sowers, JR
   McFarlane, SI
AF Forte, Victoria
   Pandey, Abhishek
   Abdelmessih, Rita
   Forte, Giovanna
   Whaley-Connell, Adam
   Sowers, James R.
   McFarlane, Samy I.
TI Obesity, Diabetes, the Cardiorenal Syndrome, and Risk for Cancer
SO CARDIORENAL MEDICINE
LA English
DT Review
DE Insulin resistance; Cancer; Inflammation; Oxidative stress
ID BODY-MASS INDEX; TUMOR-NECROSIS-FACTOR; LIFE-STYLE INTERVENTION;
   QUALITY-OF-LIFE; BREAST-CANCER; INSULIN SENSITIVITY; WEIGHT CHANGE;
   PANCREATIC-CANCER; COLORECTAL-CANCER; FAT DISTRIBUTION
AB Numerous epidemiological studies confirm that the prevalence of obesity and the cardiorenal metabolic syndrome (CRS) is extraordinarily high and that the rates have increased dramatically in the last three decades. In addition, epidemiological data demonstrate that obesity, the CRS, and diabetes are inextricably linked and are all associated with an increased incidence of a number of solid tissue cancers. The mechanisms for this association have been examined, including, but not limited to, higher levels of insulin and free levels of insulin-like growth factor and insulin resistance in obesity and the CRS. Mortality, morbidity, and the associated health care costs which are the link between obesity, the CRS, and diabetes are just beginning to be examined. In addition, we review the advantages of implementing lifestyle and surgical changes to modify obesity, lessening the development of the CRS, diabetes, and associated cancers. Epidemiological data regarding the general mechanisms of the pathogenesis of cancers associated with obesity, the CRS, and diabetes (specifically colon, pancreas, esophageal, liver, breast, prostate, thyroid, and renal carcinomas) are reviewed. The mechanisms by which obesity and other components of the CRS contribute to the pathogenesis of these cancers, such as hormone alterations and insulin- and insulin-like growth factor-dependent pathways of tumor pathogenesis, include the attending roles of inflammation and oxidative stress. Emphasis has been placed on obesity as a modifiable risk factor which, when addressed, provides a reduction in the rate of cancer deaths. In a second part to be published in the next issue of this journal, the relationship between diabetes and cancer will be reviewed in detail. Copyright (C) 2012 S. Karger AG, Basel
C1 [Forte, Victoria; Pandey, Abhishek; Abdelmessih, Rita; Forte, Giovanna; McFarlane, Samy I.] Suny Downstate Med Ctr, Dept Med, Brooklyn, NY 11203 USA.
   [Forte, Victoria; Pandey, Abhishek; Abdelmessih, Rita; Forte, Giovanna; McFarlane, Samy I.] Kings Cty Hosp Ctr, Brooklyn, NY USA.
   [Whaley-Connell, Adam; Sowers, James R.] Univ Missouri, Dept Internal Med, Columbia, MO USA.
   [Sowers, James R.] Univ Missouri, Dept Med Physiol & Pharmacol, Columbia, MO USA.
   [Sowers, James R.] VA Med Ctr, Columbia, MO USA.
C3 State University of New York (SUNY) System; SUNY Downstate Health
   Sciences University; University of Missouri System; University of
   Missouri Columbia; University of Missouri System; University of Missouri
   Columbia
RP McFarlane, SI (corresponding author), Suny Downstate Med Ctr, Dept Med, 450 Clarkson Ave,Box 50, Brooklyn, NY 11203 USA.
EM samy.mcfarlane@downstate.edu
OI Knotts, Rita/0000-0002-3133-1772; Pandey, Abhishek/0000-0003-1588-3697
FU NIH [R01 HL73101, R01 HL107910-01]; Veterans Affairs Merit System [0018]
FX The authors thank Brenda Hunter for editing the manuscript. Research in
   the Sowers and Whaley-Connell laboratories is supported by NIH (R01
   HL73101 and R01 HL107910-01) and Veterans Affairs Merit System 0018
   (J.R.S.).
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NR 134
TC 37
Z9 44
U1 0
U2 8
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1664-3828
EI 1664-5502
J9 CARDIORENAL MED
JI CardioRenal Med.
PY 2012
VL 2
IS 2
BP 143
EP 162
DI 10.1159/000337314
PG 20
WC Cardiac & Cardiovascular Systems; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Urology & Nephrology
GA 051ZP
UT WOS:000312167800007
PM 22851963
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Song, YQ
   Cook, NR
   Albert, CM
   Van Denburgh, M
   Manson, JE
AF Song, Yiqing
   Cook, Nancy R.
   Albert, Christine M.
   Van Denburgh, Martin
   Manson, JoAnn E.
TI Effect of Homocysteine-Lowering Treatment With Folic Acid and B Vitamins
   on Risk of Type 2 Diabetes in Women A Randomized, Controlled Trial
SO DIABETES
LA English
DT Article
ID INSULIN-RESISTANCE; ENDOTHELIAL DYSFUNCTION; CARDIOVASCULAR-DISEASE;
   METABOLIC SYNDROME; OXIDATIVE STRESS; SUPPLEMENTATION; SENSITIVITY;
   OBESITY; HYPERHOMOCYSTEINEMIA; METAANALYSIS
AB OBJECTIVE-Homocysteinemia may play an etiologic role in the pathogenesis of type 2 diabetes by promoting oxidative stress, systemic inflammation, and endothelial dysfunction. We investigated whether homocysteine-lowering treatment by B vitamin supplementation prevents the risk of type 2 diabetes.
   RESEARCH DESIGN AND METHODS-The Women's Antioxidant and Folic Acid Cardiovascular Study (WAFACS), a randomized, double-blind, placebo-controlled trial of 5,442 female health professionals aged >= 40 years with a history of cardiovascular disease (CVD) or three or more CVD risk factors, included 4,252 women free of diabetes at baseline. Participants were randomly assigned to either an active treatment group (daily intake of a combination pill of 2.5 mg folic acid, 50 mg vitamin 136, and 1 mg vitamin 1312) or to the placebo group.
   RESULTS-During a median follow-up of 7.3 years, 504 women had an incident diagnosis of type 2 diabetes. Overall, there was no significant difference between the active treatment group and the placebo group in diabetes risk (relative risk 0.94 [95% CI 0.79-1.11]; P = 0.46), despite significant lowering of homocysteine levels. Also, there was no evidence for effect modifications by baseline intakes of dietary folate, vitamin 136, and vitamin B12. In a sensitivity analysis, the null result remained for women compliant with their study pills (0.92 [0.76-1.10]; P = 0.36).
   CONCLUSIONS-Lowering homocysteine levels by daily supplementation with folic acid and vitamins 136 and B12 did not reduce the risk of developing type 2 diabetes among women at high risk for CVD. Diabetes 58:1921-1928, 2009
C1 [Song, Yiqing; Cook, Nancy R.; Albert, Christine M.; Van Denburgh, Martin; Manson, JoAnn E.] Harvard Univ, Brigham & Womens Hosp, Sch Med, Div Prevent Med, Boston, MA 02115 USA.
   [Cook, Nancy R.; Manson, JoAnn E.] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.
   [Albert, Christine M.] Harvard Univ, Brigham & Womens Hosp, Sch Med, Div Cardiol, Boston, MA 02115 USA.
C3 Harvard University; Harvard University Medical Affiliates; Brigham &
   Women's Hospital; Harvard Medical School; Harvard University; Harvard
   T.H. Chan School of Public Health; Harvard University; Harvard Medical
   School; Harvard University Medical Affiliates; Brigham & Women's
   Hospital
RP Song, YQ (corresponding author), Harvard Univ, Brigham & Womens Hosp, Sch Med, Div Prevent Med, Boston, MA 02115 USA.
EM ysong3@rics.bwh.harvard.edu
RI Manson, JoAnn/JOZ-3576-2023; Cook, Nancy/AGV-1570-2022
OI Albert, Christine/0000-0002-2081-1121
FU National Heart, Lung, and Blood Institute (NHLBI) [HL46959]; National
   Institute of Diabetes and Digestive and Kidney Diseases, National
   Institutes of Health [K01-DK078846]
FX This study was supported by investigator-initiated grant HL46959 from
   the National Heart, Lung, and Blood Institute (NHLBI). Y.S. is supported
   by a grant (K01-DK078846) from the National Institute of Diabetes and
   Digestive and Kidney Diseases, National Institutes of Health.
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NR 34
TC 58
Z9 65
U1 0
U2 11
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0012-1797
EI 1939-327X
J9 DIABETES
JI Diabetes
PD AUG
PY 2009
VL 58
IS 8
BP 1921
EP 1928
DI 10.2337/db09-0087
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 478TD
UT WOS:000268610300027
PM 19491213
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Mansky, P
   Arai, A
   Stratton, P
   Bernstein, D
   Long, L
   Reynolds, J
   Chen, D
   Steinberg, SM
   Lavende, N
   Hoffman, K
   Nathan, PC
   Parks, R
   Augustine, E
   Chaudhry, U
   Derdak, J
   Wiener, L
   Gerber, L
   Mackall, C
AF Mansky, Patrick
   Arai, Andrew
   Stratton, Pamela
   Bernstein, Donna
   Long, Lauren
   Reynolds, James
   Chen, Donna
   Steinberg, Seth M.
   Lavende, Neil
   Hoffman, Karen
   Nathan, Paul C.
   Parks, Rebecca
   Augustine, Elizabeth
   Chaudhry, Usha
   Derdak, Joanne
   Wiener, Lori
   Gerber, Lynn
   Mackall, Crystal
TI Treatment late effects in long-term survivors of pediatric sarcoma
SO PEDIATRIC BLOOD & CANCER
LA English
DT Article
DE cancer survivors; cardiac; infertility; late effects; musculoskeletal;
   renal; stress; treatment
ID ACUTE LYMPHOBLASTIC-LEUKEMIA; CHILDHOOD-CANCER SURVIVORS; STRESS
   ECHOCARDIOGRAPHY; DOXORUBICIN THERAPY; METABOLIC SYNDROME;
   EWINGS-SARCOMA; RISK-FACTORS; RADIOTHERAPY; NEOPLASMS
AB Purpose. To assess health and musculoskeletal function in survivors of pediatric sarcomas. Patients and Methods. Thirty-two individuals treated for Ewing sarcoma family of tumors (ESFT), rhabdomyosarcoma (RMS), or non-rhabdomyosarcoma soft tissue sarcomas (NR-STS) with multi-modality therapy were enrolled on this cross-sectional study. Median age at the time of therapy was 15.4 years (range 7.1-34.2), median age at the time of analysis was 37.4 years (17.5-55.4), and median duration of time elapsed from completion of therapy was 17.3 years (2.9-32.6). Participants underwent assessments of musculoskeletal functioning, cardiac function, metabolic and lipid analyses, renal and gonadal function, and psychological evaluation. Results. This cohort of sarcoma survivors shows expected locoregional limitations in function of the area affected by sarcoma, and impaired global musculoskeletal functioning as evidenced by limited endurance and limited overall activity levels. The cohort also demonstrated substantial rates of cardiac dysfunction, elevated body fat index, hyperlipidemia, chronic psychological distress, and infertility in men (76%) and premature menopause (49%) in women. Conclusion. Sarcoma Survivors demonstrate diminished locoregional and global musculoskeletal functioning which likely limit occupational opportunities and socioeconomic health. in addition, the combination of diminished cardiac reserve, limited activity levels, and lipid dysregulation in sarcoma survivors suggests that this population is at increased risk for cardiovascular disease, even many years following completion of sarcoma therapy. Sarcoma survivors may benefit from life long follow-Lip for cardiovascular disease and from occupational counseling upon completion of therapy.
C1 NIH, Div Intramural Res, Natl Ctr Complementary & Alternat Med, DHHS, Bethesda, MD 20892 USA.
   NCI, Pediat Oncol Branch, Ctr Canc Res, Bethesda, MD 20892 USA.
   NCI, Biostat & Data Management Sect, Ctr Canc Res, Bethesda, MD 20892 USA.
   Ctr Clin, Dept Nucl Med, Bethesda, MD USA.
   Ctr Clin, Dept Rehabil Med, Bethesda, MD USA.
   NICHHD, Reprod Biol & Med Branch, Bethesda, MD 20892 USA.
   NHLBI, Cardiac Energet Lab, NIH, DHHS, Bethesda, MD 20892 USA.
   Univ Virginia Hlth Syst, Dept Publ Hlth Sci, Charlottesville, VA USA.
C3 National Institutes of Health (NIH) - USA; Division of Intramural
   Research (DIR); NIH National Center for Complementary & Alternative
   Medicine (NCCAM); National Institutes of Health (NIH) - USA; NIH
   National Cancer Institute (NCI); National Institutes of Health (NIH) -
   USA; NIH National Cancer Institute (NCI); National Institutes of Health
   (NIH) - USA; NIH Clinical Center (CC); National Institutes of Health
   (NIH) - USA; NIH Clinical Center (CC); National Institutes of Health
   (NIH) - USA; NIH Eunice Kennedy Shriver National Institute of Child
   Health & Human Development (NICHD); National Institutes of Health (NIH)
   - USA; NIH National Heart Lung & Blood Institute (NHLBI); University of
   Virginia; University of Virginia (UVA) Health System
RP Mansky, P (corresponding author), NIH, Div Intramural Res, Natl Ctr Complementary & Alternat Med, DHHS, 10 Ctr Dr,Bldg 10,CRC,Room 4-1730,MSC 1302, Bethesda, MD 20892 USA.
EM manskyp@mail.nih.gov
RI Nathan, Paul/GRR-2377-2022; Wiener, Lori/Q-8448-2016
OI Nathan, Paul/0000-0003-0334-0871; Arai, Andrew E/0000-0002-5413-1466;
   Gerber, Lynn/0000-0001-7525-680X; Wiener, Lori/0000-0002-9573-8870
FU Intramural NIH HHS Funding Source: Medline
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NR 28
TC 55
Z9 64
U1 0
U2 6
PU WILEY-LISS
PI HOBOKEN
PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 1545-5009
J9 PEDIATR BLOOD CANCER
JI Pediatr. Blood Cancer
PD FEB
PY 2007
VL 48
IS 2
BP 192
EP 199
DI 10.1002/pbc.20871
PG 8
WC Oncology; Hematology; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Hematology; Pediatrics
GA 117LX
UT WOS:000242875800013
PM 16642490
DA 2025-06-11
ER

PT J
AU Lababidi, H
   Lababidi, G
   Al Rifai, M
   Nasir, K
   Al-Kindi, S
AF Lababidi, Hossam
   Lababidi, Ghena
   Al Rifai, Mahmoud
   Nasir, Khurram
   Al-Kindi, Sadeer
TI Cardiovascular disease in Arab Americans: A literature review of
   prevalence, risk factors, and directions for future research
SO AMERICAN JOURNAL OF PREVENTIVE CARDIOLOGY
LA English
DT Review
DE Cardiovascular disease; Arab Americans; Non -hispanic white; Disease
   burden
ID METABOLIC SYNDROME; ACCULTURATIVE STRESS; SOCIOECONOMIC-STATUS;
   INSULIN-RESISTANCE; DIABETES-MELLITUS; MIDDLE-EASTERN; HEART-DISEASE;
   VITAMIN-D; HEALTH; DISPARITIES
AB Cardiovascular disease (CVD) is the leading cause of mortality worldwide. Recent evidence suggests Arab Americans, individuals with ancestry from Arabic-speaking countries, have an elevated risk for CVD compared to other ethnicities in the US. However, research focusing specifically on CVD in this population is limited. This literature review synthesizes studies investigating CVD prevalence, risk factors, and outcomes in Arab Americans. Multiple studies found higher rates of coronary heart disease, cerebrovascular disease, and hypertension compared to non-Hispanic White participants. The prevalence of type 2 diabetes, a major CVD risk factor, was also markedly higher, ranging from 16 % to 41 % in Arab Americans based on objective measures. Possible explanations include high rates of vitamin D deficiency, genetic factors, and poor diabetes control. Other metabolic factors like dyslipidemia and obesity did not consistently differ from general population estimates. Psychosocial factors may further increase CVD risk, including acculturative stress, discrimination, low health literacy, and barriers to healthcare access. Smoking, especially waterpipe use, was more prevalent in Arab American men. Though heterogenous, Arab Americans overall appear to have elevated CVD risk, warranting tailored screening and management. Culturally appropriate educational initiatives on CVD prevention are greatly needed. Future directions include better characterizing CVD prevalence across Arab American subgroups, delineating genetic and environmental factors underlying increased diabetes susceptibility, and testing culturally tailored interventions to mitigate CVD risks. In summary, this review highlights concerning CVD disparities in Arab Americans and underscores the need for group-specific research and preventive strategies.
C1 [Lababidi, Hossam; Al Rifai, Mahmoud; Nasir, Khurram; Al-Kindi, Sadeer] Houston Methodist Hosp, Houston Methodist DeBakey Heart & Vasc Inst, 6550 Fannin St, Houston, TX 77030 USA.
   [Lababidi, Ghena] Amer Univ Beirut, Med Program, Beirut, Lebanon.
C3 Houston Methodist; American University of Beirut
RP Al-Kindi, S (corresponding author), Houston Methodist Hosp, Houston Methodist DeBakey Heart & Vasc Inst, 6550 Fannin St, Houston, TX 77030 USA.
EM sal-kindi@houstonmethodist.org
RI Al-Kindi, Sadeer/AAO-9192-2020; Nasir, Khurram/A-2317-2008
OI Lababidi, Hossam/0009-0004-7648-3229
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NR 93
TC 2
Z9 3
U1 1
U2 2
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2666-6677
J9 AM J PREVENT CARDIOL
JI American J. Preventive Cardiology
PD JUN
PY 2024
VL 18
AR 100665
DI 10.1016/j.ajpc.2024.100665
EA APR 2024
PG 10
WC Cardiac & Cardiovascular Systems
WE Emerging Sources Citation Index (ESCI)
SC Cardiovascular System & Cardiology
GA RI1Q6
UT WOS:001226947900001
PM 38634110
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Lu, Z
   Wen, TY
   Wang, YT
   Kan, WJ
   Xun, GL
AF Lu, Zhe
   Wen, Tianyang
   Wang, Yingtan
   Kan, Weijing
   Xun, Guanglei
TI Peripheral non-enzymatic antioxidants in patients with schizophrenia: a
   case-control study
SO BMC PSYCHIATRY
LA English
DT Article
DE Schizophrenia; Uric acid; Albumin; Total bilirubin
ID OXIDATIVE STRESS; LIPID-PEROXIDATION; METABOLIC SYNDROME; FREE-RADICALS;
   URIC-ACID; IN-VITRO; OLANZAPINE; SYMPTOMS; CAPACITY
AB Background Recent studies show that oxidative stress is associated with the pathogenesis of schizophrenia. There are two major types of antioxidant systems in vivo, namely enzymatic antioxidants and non-enzymatic antioxidants. This study investigated differences of non-enzymatic antioxidants between schizophrenia patients and healthy controls. Methods Peripheral UA, ALB, and TBIL of 107 schizophrenic patients in the acute stage and 101 in the remission stage were measured respectively, so were 273 healthy controls. Results The levels of UA (P = 0.020) and TBIL (P < 0.001) of schizophrenic patients in the acute stage were higher than those of healthy controls, while the level of ALB (P < 0.001) was lower. Similar results were detected form schizophrenic patients in the remission stage. Schizophrenic patients in the acute stage were divided into antipsychotics-use subgroup (n = 56) and antipsychotics-naive/free subgroup (n = 51). The level of UA (P = 0.001) in the antipsychotics-use subgroup was higher than that in the antipsychotics-naive/free subgroup, while the level of TBIL (P = 0.002) was lower than that in the antipsychotics-naive/free subgroup. Seventy-seven schizophrenic patients in the acute stage were followed up, and there was no significant difference in the level of UA before and after treatment, but levels of ALB (P < 0.001) and TBIL (P < 0.001) decreased significantly after the treatment. Conclusion This study demonstrated that the dysfunction of the peripheral non-enzymatic anti-oxidation system might be involved in the pathogenesis of schizophrenia.
C1 [Lu, Zhe] Shandong Univ, Cheeloo Coll Med, 44 Wenhua Western Rd, Jinan 250012, Peoples R China.
   [Wen, Tianyang; Xun, Guanglei] Shandong Mental Hlth Ctr, 49 Wenhua Eastern Rd, Jinan 250014, Peoples R China.
   [Wang, Yingtan] Jining Med Univ, Dept Mental Hlth, 133 Hehua Rd, Jining 272067, Peoples R China.
   [Kan, Weijing] Capital Med Univ, Beijing An Ding Hosp, China Natl Clin Res Ctr Mental Disorders, Beijing, Peoples R China.
C3 Shandong University; Jining Medical University; Capital Medical
   University
RP Xun, GL (corresponding author), Shandong Mental Hlth Ctr, 49 Wenhua Eastern Rd, Jinan 250014, Peoples R China.
EM xungl2019@163.com
RI Lu, Zhe/GYJ-5494-2022
OI Xun, Guanglei/0000-0001-8024-8046
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NR 45
TC 21
Z9 23
U1 1
U2 8
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-244X
J9 BMC PSYCHIATRY
JI BMC Psychiatry
PD MAY 15
PY 2020
VL 20
IS 1
AR 241
DI 10.1186/s12888-020-02635-8
PG 9
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA LS0KR
UT WOS:000536083500002
PM 32414343
OA Green Submitted, gold, Green Published
DA 2025-06-11
ER

PT J
AU Rothermel, J
   Kulle, A
   Holterhus, PM
   Toschke, C
   Lass, N
   Reinehr, T
AF Rothermel, Juliane
   Kulle, Alexandra
   Holterhus, Paul-Martin
   Toschke, Christina
   Lass, Nina
   Reinehr, Thomas
TI Copeptin in obese children and adolescents: relationships to body mass
   index, cortisol and gender
SO CLINICAL ENDOCRINOLOGY
LA English
DT Article
ID PLASMA COPEPTIN; ARGININE-VASOPRESSIN; INSULIN-RESISTANCE;
   BLOOD-PRESSURE; GLUCOSE; STRESS; MARKER; HOMEOSTASIS; POPULATION;
   OVERWEIGHT
AB ObjectiveCopeptin has been reported to be associated with stress, obesity and the metabolic syndrome (MetS) in adults. However, data in childhood are scarce. Therefore, we studied the relationships between copeptin, cortisol, puberty and parameters of the MetS in children.
   DesignCross-sectional study.
   PatientsA total of 51 obese children (108 32 years, 39% male, 45% prepubertal, body mass index standard deviation score (BMI-SDS) 277 056) and 24 lean children of similar age, gender and pubertal stage.
   MeasurementsCopeptin, serum cortisol, 24-h urinary free cortisol, BMI-SDS and, as parameters of the MetS, insulin resistance index (HOMA), HbA1c, uric acids, blood pressure and lipids.
   ResultsCopeptin levels were significantly (P = 0047) higher in obese children (58 +/- 28pmol/l) compared to lean children (46 +/- 22pmol/l). BMI-SDS (-coefficient 038 +/- 035, P =0033), but not any parameter of the MetS, was significantly related to copeptin in multiple linear regression analyses adjusted for age, gender and pubertal stage. A 24-h urinary free cortisol (-coefficient 013 +/- 006, P < 0001), but not serum cortisol, was significantly related to copeptin in multiple linear regression analyses adjusted for age, gender, pubertal stage and BMI-SDS. Pubertal boys (66 +/- 28pmol/l) demonstrated significantly (P = 0042) higher copeptin levels compared to pubertal girls (48 +/- 26pmol/l), while copeptin concentrations did not differ between prepubertal girls and boys.
   ConclusionsCopeptin levels are related to 24-h urinary free cortisol in obese children. Pubertal boys, but not prepubertal boys, demonstrated higher copeptin levels than girls, suggesting that sex hormones are involved in the regulation of copeptin levels. Further studies are necessary to understand the relationship between obesity, cortisol, gender, pubertal stage and copeptin levels.
C1 [Rothermel, Juliane; Toschke, Christina; Lass, Nina; Reinehr, Thomas] Univ Witten Herdecke, Vest Hosp Children & Adolescents Datteln, Dept Pediat Endocrinol Diabet & Nutr Med, Dr Steiner Str 5, D-45711 Datteln, Germany.
   [Kulle, Alexandra; Holterhus, Paul-Martin] Univ Kiel, CAU, UKSH, Univ Hosp Schleswig Holstein,Div Pediat Endocrino, Campus Kiel, Kiel, Germany.
C3 Witten Herdecke University; University of Kiel; Schleswig Holstein
   University Hospital
RP Reinehr, T (corresponding author), Univ Witten Herdecke, Vest Hosp Children & Adolescents Datteln, Dept Pediat Endocrinol Diabet & Nutr Med, Dr Steiner Str 5, D-45711 Datteln, Germany.
EM T.Reinehr@kinderklinik-datteln.de
RI Holterhus, Paul/E-4579-2010; Kulle, Alexandra/IYS-9101-2023
OI Kulle, Alexandra/0000-0002-4411-6879
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NR 38
TC 36
Z9 38
U1 0
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0300-0664
EI 1365-2265
J9 CLIN ENDOCRINOL
JI Clin. Endocrinol.
PD DEC
PY 2016
VL 85
IS 6
BP 868
EP 873
DI 10.1111/cen.13235
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA EC1DU
UT WOS:000387844500007
PM 27624976
DA 2025-06-11
ER

PT J
AU Sergina, S
   Baishnikova, I
   Ilyukha, V
   Lis, M
   Lapinski, S
   Niedbala, P
   Barabasz, B
AF Sergina, Svetlana
   Baishnikova, Irina
   Ilyukha, Viktor
   Lis, Marcin
   Lapinski, Stanislaw
   Niedbala, Piotr
   Barabasz, Bougslaw
TI Comparison of the antioxidant system response to melatonin implant in
   raccoon dog (Nyctereutes procyonoides) and silver fox (Vulpes
   vulpes)
SO TURKISH JOURNAL OF VETERINARY & ANIMAL SCIENCES
LA English
DT Article
DE Catalase; glutathione; superoxide dismutase; metabolic syndrome; Canidae
ID OXIDATIVE STRESS; EXOGENOUS MELATONIN; ALPHA-TOCOPHEROL; DIET;
   METABOLISM
AB The aim of this work was to investigate whether melatonin implant may modify the response of the antioxidant systems of raccoon dog and silver fox. Animals of each species were divided into 2 equal groups: implanted with 12 mg of melatonin in late June and not implanted (control). During the standard fur production process in late November, samples of tissues (liver, kidney, spleen, and heart) were collected and specific activities of superoxide dismutase (SOD) and catalase (CAT), and the contents of reduced glutathione (GSH), retinol, a-tocopherol (TCP), and total tissue protein, were determined in tissue samples. Activity of antioxidant enzymes SOD and CAT as well as concentrations of GSH and TCP were considerably higher in organs of raccoon dogs in comparison with silver foxes at the end of autumn fattening. Melatonin implants had no significant effect on the fox antioxidant system in contrast to the raccoon dog. The SOD activity in the liver, kidney, and heart of melatonin-treated raccoon dog considerably decreased, by 25% to 70%. The CAT activity was reduced in the kidney and heart, but it increased in the liver and spleen. Simultaneously, concentrations of GSH in the examined organs of the raccoon dog showed an inverse relationship with CAT activity. In summary, raccoon dogs and silver foxes differ not only in the function of the antioxidant system but also in the response of this system to exogenous melatonin. The rapid fattening evokes oxidative stress, which stimulates the activity of the antioxidant system in this species.
C1 [Sergina, Svetlana; Baishnikova, Irina; Ilyukha, Viktor] Russian Acad Sci, Inst Biol, Karelian Res Ctr, Petrozavodsk, Russia.
   [Lis, Marcin; Lapinski, Stanislaw; Niedbala, Piotr; Barabasz, Bougslaw] Agr Univ Krakow, Dept Poultry & Fur Anim Breeding & Anim Hyg, Krakow, Poland.
C3 Russian Academy of Sciences; Karelian Research Centre of the Russian
   Academy of Sciences; Karelia Scientific Centre Institute Biology;
   Institute of Biology of Karelian Research Centre RAS; University of
   Agriculture in Krakow
RP Lapinski, S (corresponding author), Agr Univ Krakow, Dept Poultry & Fur Anim Breeding & Anim Hyg, Krakow, Poland.
EM s.lapinski@ur.krakow.pl
RI Baishnikova, Irina/AAC-3079-2019; Kalinina, Svetlana/K-7512-2017;
   Ilyukha, Viktor/GQQ-0001-2022; Lapinski, Stanislaw/JOK-3085-2023; Lis,
   Marcin/M-1139-2019; Lis, Marcin Wojciech/D-8811-2019
OI Lapinski, Stanislaw/0000-0002-6813-1117; Kalinina,
   Svetlana/0000-0003-1906-092X; Lis, Marcin Wojciech/0000-0002-8609-572X;
   Niedbala, Piotr/0000-0001-6289-5952
FU President of the Russian Federation [3731.2010.4]; Russian-Polish
   Interacademic Cooperation
FX This study was supported by a grant from the President of the Russian
   Federation (3731.2010.4.) and a grant for Russian-Polish Interacademic
   Cooperation. We extend special thanks to Dr Hieronim Zurek from the
   "Wladkowice" fur farm for providing animals and for help in the
   research.
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NR 30
TC 4
Z9 6
U1 0
U2 19
PU Tubitak Scientific & Technological Research Council Turkey
PI ANKARA
PA ATATURK BULVARI NO 221, KAVAKLIDERE, TR-06100 ANKARA, TURKIYE
SN 1300-0128
J9 TURK J VET ANIM SCI
JI Turk. J. Vet. Anim. Sci.
PD DEC
PY 2013
VL 37
IS 6
BP 641
EP 646
DI 10.3906/vet-1302-48
PG 6
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA 258HK
UT WOS:000327449800005
OA Bronze
DA 2025-06-11
ER

PT J
AU Santos-González, M
   López-Miranda, J
   Pérez-Jiménez, F
   Navas, P
   Villalba, JM
AF Santos-Gonzalez, Monica
   Lopez-Miranda, Jose
   Perez-Jimenez, Francisco
   Navas, Placido
   Villalba, Jose M.
TI Dietary oil modifies the plasma proteome during aging in the rat
SO AGE
LA English
DT Article
DE Fatty acids; Olive oil; Plasma proteome; Rat; Sunflower oil
ID MOLECULAR-WEIGHT KININOGEN; APOLIPOPROTEIN A-IV; D-BINDING-PROTEIN;
   OLIVE OIL; CLUSTERIN/APOLIPOPROTEIN-J; OXIDATIVE STRESS;
   CARDIOVASCULAR-DISEASE; DENSITY-LIPOPROTEIN; MEDITERRANEAN DIET;
   METABOLIC SYNDROME
AB Fatty acids and other components of the diet may modulate, among others, mechanisms involved in homeostasis, aging, and age-related diseases. Using a proteomic approach, we have studied how dietary oil affected plasma proteins in young (6 months) or old (24 months) rats fed lifelong with two experimental diets enriched in either sunflower or virgin olive oil. After the depletion of the most abundant proteins, levels of less abundant proteins were studied using two-dimensional electrophoresis and mass spectrometry. Our results showed that compared with the sunflower oil diet, the virgin olive oil diet induced significant decreases of plasma levels of acute phase proteins such as inter-alpha inhibitor H4P heavy chain (at 6 months), hemopexin precursor (at 6 and 24 months), preprohaptoglobin precursor (at 6 and 24 months), and alpha-2-HS glycoprotein (at 6 and 24 months); antioxidant proteins such as type II peroxiredoxin (at 24 months); proteins related with coagulation such as fibrinogen gamma-chain precursor (at 24 months), T-kininogen 1 precursor (at 6 and 24 months), and apolipoprotein H (at 6 and 24 months); or with lipid metabolism and transport such as apolipoprotein E (at 6 and 24 months) and apolipoprotein A-IV (at 24 months). The same diet increased the levels of apolipoprotein A-1 (at 6 and 24 months), diminishing in general the changes that occurred with age. Our unbiased analysis reinforces the beneficial role of a diet rich in virgin olive oil compared with a diet rich in sunflower oil, modulating inflammation, homeostasis, oxidative stress, and cardiovascular risk during aging.
C1 [Santos-Gonzalez, Monica; Villalba, Jose M.] Univ Cordoba, Dept Biol Celular Fisiol & Inmunol, Cordoba 14014, Spain.
   [Lopez-Miranda, Jose; Perez-Jimenez, Francisco] Univ Cordoba, IMIBIC Reina Sofia Univ Hosp, Lipid & Atherosclerosis Unit, Cordoba 14014, Spain.
   [Lopez-Miranda, Jose; Perez-Jimenez, Francisco] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr CIBEROB, Cordoba, Spain.
   [Navas, Placido] Univ Pablo de Olavide, CSIC, CABD, Seville, Spain.
   [Navas, Placido] Inst Salud Carlos III, CIBER Enfermedades Raras CIBERER, Seville, Spain.
C3 Universidad de Cordoba; Universidad de Cordoba; CIBER - Centro de
   Investigacion Biomedica en Red; CIBEROBN; Instituto de Salud Carlos III;
   Consejo Superior de Investigaciones Cientificas (CSIC); Universidad
   Pablo de Olavide; CSIC - Andalusian Center for Developmental Biology
   (CABD); CIBER - Centro de Investigacion Biomedica en Red; CIBERER;
   Instituto de Salud Carlos III
RP Villalba, JM (corresponding author), Univ Cordoba, Dept Biol Celular Fisiol & Inmunol, Campus Rabanales Ed Severo Ochoa,3A Planta, Cordoba 14014, Spain.
EM jmvillalba@uco.es
RI Lopez-Miranda, Jose/Y-8306-2019; NAVAS, PLACIDO/R-5943-2019; Santos
   Gonzalez, Monica/JBJ-6337-2023; Jimenez, Francisco/AAJ-9559-2021
OI Perez Jimenez, Francisco/0000-0001-9808-1280; Santos-Gonzalez,
   Monica/0000-0002-3672-5674; Lopez-Miranda, Jose/0000-0002-8844-0718;
   Perez-Jimenez, Francisco/0000-0001-7499-7681; Villalba Montoro, Jose
   Manuel/0000-0001-8554-3802
FU Junta de Andalucia [P09-CVI-4887, BIO-276, AGR-922]; University of
   Cordoba;  [AGR922]
FX The proteomic analysis was carried out in the UCO-SCAI proteomics
   facility, a member of ProteoRed network. This work was supported by a
   Proyectos Internacionales Grant from Junta de Andalucia to JMV, a
   Proyectos de Excelencia Grant (P09-CVI-4887) from Junta de Andalucia to
   JMV, BIO-276 Grants from Junta de Andalucia and the University of
   Cordoba to JMVM, and a Proyectos de Excelencia Grant (AGR-922) from
   Junta de Andalucia) to FPJ. MS was funded by AGR922 and BIO-276 Grants.
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NR 72
TC 10
Z9 10
U1 0
U2 7
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0161-9152
EI 1574-4647
J9 AGE
JI Age
PD APR
PY 2012
VL 34
IS 2
BP 341
EP 358
DI 10.1007/s11357-011-9239-z
PG 18
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA 899YT
UT WOS:000300853300007
PM 21472381
OA Green Published
DA 2025-06-11
ER

PT J
AU Fan, YY
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AF Fan, Yu-Yan
   Kohno, Masakazu
   Nakano, Daisuke
   Ohsaki, Hiroyuki
   Kobori, Hiroyuki
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   Ohashi, Naro
   Hitomi, Hirofumi
   Asanuma, Katsuhiko
   Noma, Takahisa
   Tomino, Yasuhiko
   Fujita, Toshiro
   Nishiyama, Akira
TI Cilnidipine suppresses podocyte injury and proteinuria in metabolic
   syndrome rats: possible involvement of N-type calcium channel in
   podocyte
SO JOURNAL OF HYPERTENSION
LA English
DT Article
DE angiotensin II; oxidative stress; SHR/ND mcr-cp
ID CHRONIC KIDNEY-DISEASE; ANGIOTENSIN-II; HYPERTENSIVE PATIENTS; OXIDATIVE
   STRESS; DIABETIC-NEPHROPATHY; TUBULAR APOPTOSIS; GROWTH-FACTOR; RENAL
   INJURY; CA2+ CHANNEL; L/N-TYPE
AB Objectives Clinical studies have indicated the beneficial effect of an L/N-type calcium channel blocker (CCB), cilnidipine, on the progression of proteinuria in hypertensive patients compared with an L-type CCB, amlodipine. In the present study, we examined the effects of cilnidipine and amlodipine on the renal injury in spontaneously hypertensive rat/ND mcr-cp (SHR/ND) and their underlying mechanism.
   Methods and results SHR/ND were treated with vehicle (n=10), cilnidipine [33 mg/kg per day, orally (p.o.); n=11] or amlodipine (20 mg/kg per day, p.o.; n=9) for 20 weeks. SHR/ND developed proteinuria in an age-dependent manner. Cilnidipine suppressed the proteinuria greater than amlodipine did. The immunohistochemical analysis showed that N-type calcium channel and Wilm's tumor factor, a marker of podocyte, were co-expressed. SHR/ND had significantly greater desmin staining, an indicator of podocyte injury, with lower podocin and nephrin expression in the glomeruli than Wistar-Kyoto rat or SHR. Cilnidipine significantly prevented the increase in desmin staining and restored the glomerular podocin and nephrin expression compared with amlodipine. Cilnidipine also prevented the increase in renal angiotensin II content, the expression and membrane translocation of NADPH oxidase subunits and dihydroethidium staining in SHR/ND. In contrast, amlodipine failed to change these renal parameters.
   Conclusion These data suggest that cilnidipine suppressed the development of proteinuria greater than amlodipine possibly through inhibiting N-type calcium channel-dependent podocyte injury in SHR/ND. J Hypertens 28:1034-1043 (C) 2010 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
C1 [Nakano, Daisuke; Diah, Suwarni; Hitomi, Hirofumi; Nishiyama, Akira] Kagawa Univ, Dept Pharmacol, Fac Med, Kita, Kagawa 7610793, Japan.
   [Fan, Yu-Yan; Kohno, Masakazu; Noma, Takahisa] Kagawa Univ, Dept Cardiorenal & Cerebrovasc Med, Kita, Kagawa 7610793, Japan.
   [Ohsaki, Hiroyuki] Kagawa Prefectural Coll Hlth Sci, Pathol Lab, Dept Med Technol, Kagawa, Japan.
   [Kobori, Hiroyuki; Ohashi, Naro] Tulane Univ, Dept Physiol & Med, Hlth Sci Ctr, New Orleans, LA 70118 USA.
   [Kobori, Hiroyuki; Ohashi, Naro] Tulane Univ, Hypertens & Renal Ctr Excellence, Hlth Sci Ctr, New Orleans, LA 70118 USA.
   [Asanuma, Katsuhiko; Tomino, Yasuhiko] Juntendo Univ, Sch Med, Div Nephrol, Dept Internal Med, Tokyo 113, Japan.
   [Fujita, Toshiro] Univ Tokyo, Dept Nephrol & Endocrinol, Grad Sch Med, Tokyo, Japan.
C3 Kagawa University; Kagawa University; Tulane University; Tulane
   University; Juntendo University; University of Tokyo
RP Nakano, D (corresponding author), Kagawa Univ, Dept Pharmacol, Fac Med, 1750-1 Ikenobe, Kita, Kagawa 7610793, Japan.
EM dnakano@med.kagawa-u.ac.jp
RI NAKANO, DAISUKE/JWP-5663-2024; Hitomi, Hirofumi/ABA-2086-2021; Kobori,
   Hiroyuki/F-1994-2014
OI Kobori, Hiroyuki/0000-0001-5128-5059; Nishiyama,
   Akira/0000-0001-5971-820X
FU Ministry of Education, Culture, Sports, Science and Technology of Japan
   [20590253]; Kagawa University; National Institute of Diabetes and
   Digestive and Kidney Diseases [RO1DK072408]
FX This work was supported by a grant-in-aid for scientific research from
   the Ministry of Education, Culture, Sports, Science and Technology of
   Japan (20590253) and by a grant from Kagawa University Project Research
   2008 (to A.N.) and from the National Institute of Diabetes and Digestive
   and Kidney Diseases (RO1DK072408 to H.K.). We are grateful to Ajinomoto
   Co. for supplying cilnidipine.
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NR 44
TC 39
Z9 41
U1 0
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0263-6352
EI 1473-5598
J9 J HYPERTENS
JI J. Hypertens.
PD MAY
PY 2010
VL 28
IS 5
BP 1034
EP 1043
DI 10.1097/HJH.0b013e328336ade3
PG 10
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 583UX
UT WOS:000276706500023
PM 20411599
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Butler, AA
   Havel, PJ
AF Butler, Andrew A.
   Havel, Peter J.
TI Adropin: A cardio-metabolic hormone in the periphery, a neurohormone in
   the brain?
SO PEPTIDES
LA English
DT Article
DE Glycolysis; Gluconeogenesis; Liver; Pancreas; Brain; Adropin; Insulin;
   Glucagon
ID OXIDATIVE STRESS; INSULIN-RESISTANCE; OBESITY; EXPRESSION; CONSUMPTION;
   INCREASES; CORRELATE; DISEASE; BIOLOGY; ENERGY
AB Whole-body metabolic homeostasis is regulated by physiological responses across organs and tissues to proteins and peptides (<50 amino acids) released into the interstitial and circulatory spaces. These secreted factors integrate signals of metabolic status at both the cellular and systemic level, regulate the intake and distribution of ingested and stored energy substrates across tissues, and minimize toxicity from excessive excursions in circulating concentrations of energy substrates (for example, glucotoxicity and lipotoxicity). The proteins and peptides that are known to be secreted into circulation that are involved in regulating metabolic processes represent a fraction of the secretome predicted by the Human Proteome Atlas. Many undiscovered leads for targeting new therapies for metabolic diseases may therefore exist. In this review, we discuss the biology of adropin, the peptide encoded by the Energy Homeostasis Associated (ENHO) gene. First described as a feeding-responsive, liver-secreted peptide ("hepatokine") involved in metabolic homeostasis, > 2 decades of research indicate adropin is a stress-responsive peptide acting across multiple tissues, vascular, and organ systems. Adropin modulates the responses of liver and muscle to insulin and glucagon in regulating glucose homeostasis. Adropin inhibits hepatic glucose production and stimulates glycolysis but also inhibits tissue fibrosis and maintains vascular health in aging and metabolic disease states. Adropin is also highly expressed in the central nervous system where recent data suggest neuroprotective actions. Collectively, these results suggest the potential for targeting adropin in reducing risk of both metabolic (metabolic syndrome/type-2 diabetes) and neurodegenerative diseases in the context of aging and obesity.
C1 [Butler, Andrew A.] St Louis Univ, Sch Med, Dept Pharmacol & Physiol, 1402 S Grand Blvd, St. Louis, MO 63104 USA.
   [Butler, Andrew A.] St Louis Univ, Inst Translat Neurosci, St Louis, MO USA.
   [Havel, Peter J.] Univ Calif Davis, Sch Vet Med, Dept Mol Biosci, Davis, CA USA.
   [Havel, Peter J.] Univ Calif Davis, Dept Nutr, Davis, CA USA.
   [Havel, Peter J.] Univ British Columbia, Fac Med, Dept Cellular & Physiol Sci, Vancouver, BC, Canada.
C3 Saint Louis University; Saint Louis University; University of California
   System; University of California Davis; University of California System;
   University of California Davis; University of British Columbia
RP Butler, AA (corresponding author), St Louis Univ, Sch Med, Dept Pharmacol & Physiol, 1402 S Grand Blvd, St. Louis, MO 63104 USA.
EM andrew.butler@health.slu.edu
RI Havel, Peter/AFU-9329-2022
OI Butler, Andrew/0000-0001-7196-0170
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NR 69
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0196-9781
EI 1873-5169
J9 PEPTIDES
JI Peptides
PD MAY
PY 2025
VL 187
AR 171391
DI 10.1016/j.peptides.2025.171391
PG 9
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism;
   Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism;
   Pharmacology & Pharmacy
GA 1MD4Y
UT WOS:001468299100001
PM 40097041
DA 2025-06-11
ER

PT J
AU Yang, M
   Cui, XX
   Kong, D
   Huang, XC
   Zhao, GC
   Li, XY
   Zhao, HC
   Liu, LJ
   Yan, F
   Yang, Y
   Li, ZZ
AF Yang, Mi
   Cui, Xingxing
   Kong, Di
   Huang, Xincheng
   Zhao, Guocheng
   Li, Xiuying
   Zhao, Huachang
   Liu, Liju
   Yan, Fei
   Yang, Yan
   Li, Zezhi
TI The efficacy of Lactobacillus and Bifidobacterium in
   patients with schizophrenia: a meta-analysis
SO EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
LA English
DT Article; Early Access
DE Schizophrenia; Probiotics; Meta-analysis; Oxidative stress; Insulin;
   Glucose
ID MAJOR DEPRESSIVE DISORDER; METABOLIC SYNDROME; IMMUNE ACTIVATION;
   OXIDATIVE STRESS; GUT MICROBIOTA; PROBIOTICS; SYMPTOMS; SYSTEM;
   DYSFUNCTION; MECHANISMS
AB The modulation of gut microbiota through probiotics holds promise as a novel avenue for schizophrenia treatment. This study aims to analyze probiotic complementary therapy on individuals with schizophrenia systematically, to investigate probiotic efficacy, potential mechanisms, and implications for clinical practice. Adhering to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, we searched in Medline, Web of Science, Embase, ClinicalTrials.gov, CNKI, VIP, and WanFang databases using keywords ("probiotics" OR "prebiotics" OR "synbiotics" OR "Lactobacillus" OR "Bifidobacterium") AND ("schizophrenia"), focused on randomized controlled trials published before July 1, 2023. Among the identified studies, 8 randomized controlled trials met the inclusion criteria, encompassing a total of 342 participants in the intervention group and 306 participants in the control group. Our analysis revealed a statistically significant reduction (p = 0.03) in the total Positive and Negative Syndrome Scale (PANSS) scores following probiotic treatment in individuals with schizophrenia. While no statistical significance was observed in individual subscales (P > 0.05), significant improvements were noted in insulin levels, Insulin Resistance Index (IRI), and glucose levels. Additionally, the Quantitative Insulin Sensitivity Check Index (QUICKI) demonstrated a significant increase (all P < 0.05). The probiotic intervention significantly reduced gastrointestinal discomfort among schizophrenia patients (P = 0.003). This study suggests that probiotics could hold therapeutic potential for addressing clinical symptoms, abnormal glucose metabolism, and gastrointestinal discomfort in individuals with schizophrenia. Future research should encompass comparative trials employing robust experimental designs to explore the differential effects of various probiotic strains on schizophrenia treatment to provide evidence-based therapeutic approaches.
C1 [Yang, Mi; Cui, Xingxing; Kong, Di; Huang, Xincheng; Zhao, Guocheng; Zhao, Huachang; Liu, Liju; Yan, Fei; Yang, Yan] Fourth Peoples Hosp Chengdu, Dept Psychiat, 8 Huli West 1st-Alley, Chengdu 610036, Peoples R China.
   [Yang, Mi] Univ Elect Sci & Technol China, Chengdu Brain Sci Inst, MOE Key Lab Neuroinformat, Clin Hosp, Qingshuihe Campus 2006, Xiyuan Ave, West Hitech Zo, Chengdu 611731, Peoples R China.
   [Yang, Mi] Univ Elect Sci & Technol China, Sch Life Sci & Technol, Qingshuihe Campus 2006,Xiyuan Ave,West Hitech Zone, Chengdu 611731, Peoples R China.
   [Li, Xiuying] Southwest Jiaotong Univ, Psychol Res & Counseling Ctr, Chengdu 610031, Peoples R China.
   [Li, Zezhi] Guangzhou Med Univ, Affiliated Brain Hosp, Dept Psychiat, 36 Mingxin Rd, Guangzhou 510370, Peoples R China.
   [Li, Zezhi] Guangdong Engn Technol Res Ctr Translat Med Mental, Dept Psychiat, 36 Mingxin Rd, Guangzhou 510370, Peoples R China.
C3 University of Electronic Science & Technology of China; University of
   Electronic Science & Technology of China; Southwest Jiaotong University;
   Guangzhou Medical University
RP Yang, M (corresponding author), Fourth Peoples Hosp Chengdu, Dept Psychiat, 8 Huli West 1st-Alley, Chengdu 610036, Peoples R China.; Yang, M (corresponding author), Univ Elect Sci & Technol China, Chengdu Brain Sci Inst, MOE Key Lab Neuroinformat, Clin Hosp, Qingshuihe Campus 2006, Xiyuan Ave, West Hitech Zo, Chengdu 611731, Peoples R China.; Yang, M (corresponding author), Univ Elect Sci & Technol China, Sch Life Sci & Technol, Qingshuihe Campus 2006,Xiyuan Ave,West Hitech Zone, Chengdu 611731, Peoples R China.; Li, ZZ (corresponding author), Guangzhou Med Univ, Affiliated Brain Hosp, Dept Psychiat, 36 Mingxin Rd, Guangzhou 510370, Peoples R China.; Li, ZZ (corresponding author), Guangdong Engn Technol Res Ctr Translat Med Mental, Dept Psychiat, 36 Mingxin Rd, Guangzhou 510370, Peoples R China.
EM 565136170@qq.com; 853706183@qq.com; innerchild@126.com;
   264024737@qq.com; 691063728@qq.com; lixy3257@163.com; 719076783@qq.com;
   ju1336966520@qq.com; 173542558@qq.com; yangyan904@163.com;
   biolpsychiatry@126.com
RI Kong, Di/LXU-3327-2024; Yang, MI/LRT-3110-2024; huang,
   xincheng/GRE-7834-2022; Wilson, Robert/HHZ-5981-2022
FU National Natural Science Foundation of China
FX Not applicable.
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NR 97
TC 1
Z9 1
U1 7
U2 9
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0940-1334
EI 1433-8491
J9 EUR ARCH PSY CLIN N
JI Eur. Arch. Psych. Clin. Neurosci.
PD 2024 NOV 18
PY 2024
DI 10.1007/s00406-024-01935-4
EA NOV 2024
PG 15
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Psychiatry
GA M4H0K
UT WOS:001357157300001
PM 39551901
DA 2025-06-11
ER

PT J
AU Lee, J
   Xue, XN
   Au, E
   Mcintyre, WB
   Asgariroozbehani, R
   Panganiban, K
   Tseng, GC
   Papoulias, M
   Smith, E
   Monteiro, J
   Shah, D
   Maksyutynska, K
   Cavalier, S
   Radoncic, E
   Prasad, F
   Agarwal, SM
   Mccullumsmith, R
   Freyberg, Z
   Logan, RW
   Hahn, MK
AF Lee, Jiwon
   Xue, Xiangning
   Au, Emily
   Mcintyre, William B.
   Asgariroozbehani, Roshanak
   Panganiban, Kristoffer
   Tseng, George C.
   Papoulias, Maria
   Smith, Emily
   Monteiro, Jonathan
   Shah, Divia
   Maksyutynska, Kateryna
   Cavalier, Samantha
   Radoncic, Emril
   Prasad, Femin
   Agarwal, Sri Mahavir
   Mccullumsmith, Robert
   Freyberg, Zachary
   Logan, Ryan W.
   Hahn, Margaret K.
TI Glucose dysregulation in antipsychotic-naive first-episode psychosis: in
   silico exploration of gene expression signatures
SO TRANSLATIONAL PSYCHIATRY
LA English
DT Article
ID BETA/NF-KAPPA-B; INDUCED WEIGHT-GAIN; DIET-INDUCED OBESITY;
   SCHIZOPHRENIA-PATIENTS; OXIDATIVE STRESS; HYPOTHALAMIC GLIOSIS;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; BLOOD-GLUCOSE; DOUBLE-BLIND
AB Antipsychotic (AP)-naive first-episode psychosis (FEP) patients display early dysglycemia, including insulin resistance and prediabetes. Metabolic dysregulation may therefore be intrinsic to psychosis spectrum disorders (PSDs), independent of the metabolic effects of APs. However, the potential biological pathways that overlap between PSDs and dysglycemic states remain to be identified. Using meta-analytic approaches of transcriptomic datasets, we investigated whether AP-naive FEP patients share overlapping gene expression signatures with non-psychiatrically ill early dysglycemia individuals. We meta-analyzed peripheral transcriptomic datasets of AP-naive FEP patients and non-psychiatrically ill early dysglycemia subjects to identify common gene expression signatures. Common signatures underwent pathway enrichment analysis and were then used to identify potential new pharmacological compounds via Integrative Library of Integrated Network-Based Cellular Signatures (iLINCS). Our search results yielded 5 AP-naive FEP studies and 4 early dysglycemia studies which met inclusion criteria. We discovered that AP-naive FEP and non-psychiatrically ill subjects exhibiting early dysglycemia shared 221 common signatures, which were enriched for pathways related to endoplasmic reticulum stress and abnormal brain energetics. Nine FDA-approved drugs were identified as potential drug treatments, of which the antidiabetic metformin, the first-line treatment for type 2 diabetes, has evidence to attenuate metabolic dysfunction in PSDs. Taken together, our findings support shared gene expression changes and biological pathways associating PSDs with dysglycemic disorders. These data suggest that the pathobiology of PSDs overlaps and potentially contributes to dysglycemia. Finally, we find that metformin may be a potential treatment for early metabolic dysfunction intrinsic to PSDs.
C1 [Lee, Jiwon; Mcintyre, William B.; Asgariroozbehani, Roshanak; Panganiban, Kristoffer; Smith, Emily; Maksyutynska, Kateryna; Prasad, Femin; Agarwal, Sri Mahavir; Hahn, Margaret K.] Univ Toronto, Inst Med Sci, Toronto, ON, Canada.
   [Lee, Jiwon; Au, Emily; Asgariroozbehani, Roshanak; Panganiban, Kristoffer; Papoulias, Maria; Smith, Emily; Monteiro, Jonathan; Maksyutynska, Kateryna; Prasad, Femin; Agarwal, Sri Mahavir; Hahn, Margaret K.] Ctr Addict & Mental Hlth, Toronto, ON, Canada.
   [Xue, Xiangning; Tseng, George C.] Univ Pittsburgh, Grad Sch Publ Hlth, Dept Biostat, Pittsburgh, PA USA.
   [Au, Emily] Univ Toronto, Dept Pharmacol & Toxicol, Toronto, ON, Canada.
   [Shah, Divia; Cavalier, Samantha; Radoncic, Emril; Freyberg, Zachary] Univ Pittsburgh, Dept Psychiat, Pittsburgh, PA USA.
   [Logan, Ryan W.] Univ Massachusetts, Dept Neurobiol, Chan Med Sch, Worcester, MA USA.
   [Mccullumsmith, Robert] Univ Toledo, Dept Neurosci, Toledo, OH USA.
   [Mccullumsmith, Robert] ProMedica, Toledo, OH USA.
   [Freyberg, Zachary] Univ Pittsburgh, Dept Cell Biol, Pittsburgh, PA USA.
   [Logan, Ryan W.] Univ Massachusetts, Dept Psychiat, Chan Med Sch, Worcester, MA USA.
   [Logan, Ryan W.] Boston Univ, Dept Pharmacol Physiol & Biophys, Sch Med, Boston, MA USA.
   [Agarwal, Sri Mahavir; Hahn, Margaret K.] Univ Toronto, Dept Psychiat, Toronto, ON, Canada.
C3 University of Toronto; University of Toronto; Centre for Addiction &
   Mental Health - Canada; Pennsylvania Commonwealth System of Higher
   Education (PCSHE); University of Pittsburgh; University of Toronto;
   Pennsylvania Commonwealth System of Higher Education (PCSHE); University
   of Pittsburgh; University of Massachusetts System; UMass Chan Medical
   School; University of Massachusetts Worcester; University System of
   Ohio; University of Toledo; Pennsylvania Commonwealth System of Higher
   Education (PCSHE); University of Pittsburgh; University of Massachusetts
   System; UMass Chan Medical School; University of Massachusetts
   Worcester; Boston University; University of Toronto
RP Hahn, MK (corresponding author), Univ Toronto, Inst Med Sci, Toronto, ON, Canada.; Hahn, MK (corresponding author), Ctr Addict & Mental Hlth, Toronto, ON, Canada.; Hahn, MK (corresponding author), Univ Toronto, Dept Psychiat, Toronto, ON, Canada.
EM Margaret.Hahn@camh.ca
RI Hahn, Margaret/F-5034-2014; McCullumsmith, Robert/GYR-1547-2022;
   Freyberg, Zachary/L-4927-2018; Agarwal, Mahavir/ITV-3244-2023; Logan,
   Ryan/GQZ-2672-2022
OI Xue, Xiangning/0000-0002-5775-1193; , Divia Shah/0009-0001-5961-212X;
   Prasad, Femin/0000-0002-5445-2489; Logan, Ryan/0000-0001-8579-015X;
   Hahn, Margaret/0000-0001-8884-9946
FU Holds the Meighen Family Chair in Psychosis Prevention, the Cardy
   Schizophrenia Research Chair, a Danish Diabetes Academy Professorship, a
   Steno Diabetes Center Fellowship, and a U of T Academic Scholar Award,
   and is funded by operating grants from the Can; Dr. LG Rao/Industrial
   Partners Graduate Student Award from the University of Toronto, and
   Meighen Family Chair in Psychosis Prevention [R01HL150432, HL150432-S1];
   National Heart, Lung, and Blood Institute; Banting and Best Diabetes
   Centre (BBDC) Novo-Nordisk Graduate Studentship; Cleghorn Award;
   Canadian Institutes of Health Research (CIHR) Canada Graduate
   Scholarship-Master's program; BBDC Novo-Nordisk Graduate Studentship;
   Department of Psychiatry, University of Toronto; CAMH Discovery Fund
   [R01DK124219]; National Institute of Diabetes and Digestive and Kidney
   Diseases [PR192466, PR210207]; Department of Defense; Commonwealth of
   Pennsylvania Formula Fund; Pittsburgh Foundation [MH107487, MH121102];
   National Institute of Mental Health; Meighen Family Chair in Psychosis
   Prevention; Cardy Schizophrenia Research Chair; Danish Diabetes Academy
   Professorship; Steno Diabetes Center Fellowship (Novo Nordisk Fonden); U
   of T Academic Scholar Award - Canadian Institutes of Health Research
   (CIHR); Banting and Best Diabetes Center; Miners Lamp U of T award;
   CIHR; Canadian Psychiatric Association Glenda MacQueen Memorial Award;
   PSI Foundation; CAMH; U of T, Kelly and Michael Meighen Chair in
   Psychosis Prevention
FX The authors would like to thank Prof. Ulrich Schall, Dr. Nishantha
   Kumarasinghe, and Prof. Paul Tooney for kindly sharing their data.
   Figure 3 was created using BioRender (BioRender.com). JL is supported by
   the Hilda and William Courtney Clayton Paediatric Research Fund and Dr.
   LG Rao/Industrial Partners Graduate Student Award from the University of
   Toronto, and Meighen Family Chair in Psychosis Prevention. XX and RWL
   are supported by National Heart, Lung, and Blood Institute R01HL150432
   and Supplement HL150432-S1. RA is supported by the Banting and Best
   Diabetes Centre (BBDC) Novo-Nordisk Graduate Studentship and the
   Cleghorn Award. EA is supported by the Canadian Institutes of Health
   Research (CIHR) Canada Graduate Scholarship-Master's program and BBDC
   Novo-Nordisk Graduate Studentship. SMA is supported in part by an
   Academic Scholars Award from the Department of Psychiatry, University of
   Toronto, the Novo-Nordisk-BBDC New Investigator Award, and the CAMH
   Discovery Fund. ZF is supported by National Institute of Diabetes and
   Digestive and Kidney Diseases R01DK124219, Department of Defense
   PR192466 and PR210207, Commonwealth of Pennsylvania Formula Fund, and
   The Pittsburgh Foundation. RM is supported by the National Institute of
   Mental Health MH107487 and MH121102. MKH holds the Meighen Family Chair
   in Psychosis Prevention, the Cardy Schizophrenia Research Chair, a
   Danish Diabetes Academy Professorship, a Steno Diabetes Center
   Fellowship (Novo Nordisk Fonden), and a U of T Academic Scholar Award,
   and is funded by operating grants from the Canadian Institutes of Health
   Research (CIHR), the Banting and Best Diabetes Center, the Miners Lamp U
   of T award, CIHR and Canadian Psychiatric Association Glenda MacQueen
   Memorial Award, and the PSI Foundation. This work was supported by the
   CAMH and U of T, Kelly and Michael Meighen Chair in Psychosis
   Prevention.
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NR 112
TC 4
Z9 4
U1 0
U2 2
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 2158-3188
J9 TRANSL PSYCHIAT
JI Transl. Psychiatr.
PD JAN 10
PY 2024
VL 14
IS 1
AR 19
DI 10.1038/s41398-023-02716-8
PG 12
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychiatry
GA ES5V8
UT WOS:001140934600001
PM 38199991
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Denimal, D
AF Denimal, Damien
TI Antioxidant and Anti-Inflammatory Functions of High-Density Lipoprotein
   in Type 1 and Type 2 Diabetes
SO ANTIOXIDANTS
LA English
DT Review
DE HDL; oxidative stress; inflammation; diabetes; cardiovascular disease;
   paraoxonase
ID APOLIPOPROTEIN-A-I; CHOLESTEROL EFFLUX CAPACITY; ELEVATED OXIDATIVE
   STRESS; LIFE-STYLE INTERVENTION; PANCREATIC BETA-CELLS; APOA-I;
   HDL-CHOLESTEROL; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   3-BETA-HYDROXYSTEROID-DELTA-24 REDUCTASE
AB (1) Background: high-density lipoproteins (HDLs) exhibit antioxidant and anti-inflammatory properties that play an important role in preventing the development of atherosclerotic lesions and possibly also diabetes. In turn, both type 1 diabetes (T1D) and type 2 diabetes (T2D) are susceptible to having deleterious effects on these HDL functions. The objectives of the present review are to expound upon the antioxidant and anti-inflammatory functions of HDLs in both diabetes in the setting of atherosclerotic cardiovascular diseases and discuss the contributions of these HDL functions to the onset of diabetes. (2) Methods: this narrative review is based on the literature available from the PubMed database. (3) Results: several antioxidant functions of HDLs, such as paraoxonase-1 activity, are compromised in T2D, thereby facilitating the pro-atherogenic effects of oxidized low-density lipoproteins. In addition, HDLs exhibit diminished ability to inhibit pro-inflammatory pathways in the vessels of individuals with T2D. Although the literature is less extensive, recent evidence suggests defective antiatherogenic properties of HDL particles in T1D. Lastly, substantial evidence indicates that HDLs play a role in the onset of diabetes by modulating glucose metabolism. (4) Conclusions and perspectives: impaired HDL antioxidant and anti-inflammatory functions present intriguing targets for mitigating cardiovascular risk in individuals with diabetes. Further investigations are needed to clarify the influence of glycaemic control and nephropathy on HDL functionality in patients with T1D. Furthermore, exploring the effects on HDL functionality of novel antidiabetic drugs used in the management of T2D may provide intriguing insights for future research.
C1 [Denimal, Damien] Univ Burgundy, Ctr Translat & Mol Med, Unit 1231, F-21000 Dijon, France.
   [Denimal, Damien] Dijon Bourgogne Univ Hosp, Dept Clin Biochem, F-21079 Dijon, France.
C3 Institut Agro; AgroSup Dijon; Universite Bourgogne Europe; Institut
   National de la Sante et de la Recherche Medicale (Inserm); Universite
   Bourgogne Europe; CHU Dijon Bourgogne
RP Denimal, D (corresponding author), Univ Burgundy, Ctr Translat & Mol Med, Unit 1231, F-21000 Dijon, France.; Denimal, D (corresponding author), Dijon Bourgogne Univ Hosp, Dept Clin Biochem, F-21079 Dijon, France.
EM damien.denimal@u-bourgogne.fr
OI DENIMAL, Damien/0000-0001-5454-954X
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NR 203
TC 19
Z9 19
U1 2
U2 7
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD JAN
PY 2024
VL 13
IS 1
AR 57
DI 10.3390/antiox13010057
PG 26
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA FX7U4
UT WOS:001149224900001
PM 38247481
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Henson, SM
   Aksentijevic, D
AF Henson, Sian M.
   Aksentijevic, Dunja
TI Senescence and Type 2 Diabetic Cardiomyopathy: How Young Can You Die of
   Old Age?
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Review
DE type 2 diabetes; immunosenescence; diabetic cardiomyopathy;
   inflammaging; cardiac metabolism
ID NF-KAPPA-B; ENDOPLASMIC-RETICULUM STRESS; CELLULAR SENESCENCE; SECRETORY
   PHENOTYPE; ENERGY-METABOLISM; HIGH GLUCOSE; PERMEABILITY TRANSITION;
   CARDIOVASCULAR-DISEASES; PREMATURE SENESCENCE; HEART-FAILURE
AB Inflammation is well understood to be a physiological process of ageing however it also underlies many chronic diseases, including conditions without an obvious pathogenic inflammatory element. Recent findings have unequivocally identified type 2 diabetes (T2D) as a chronic inflammatory disease characterized by inflammation and immune senescence. Immunosenescence is a hallmark of the prolonged low-grade systemic inflammation, in particular associated with metabolic syndrome and can be a cause as well as a consequence of T2D. Diabetes is a risk factor for cardiovascular mortality and remodelling and with particular changes to myocardial structure, function, metabolism and energetics collectively resulting in diabetic cardiomyopathy. Both cardiomyocytes and immune cells undergo metabolic remodelling in T2D and as a result become trapped in a vicious cycle of lost metabolic flexibility, thus losing their key adaptive mechanisms to dynamic changes in O-2 and nutrient availability. Immunosenescence driven by metabolic stress may be both the cause and key contributing factor to cardiac dysfunction in diabetic cardiomyopathy by inducing metabolic perturbations that can lead to impaired energetics, a strong predictor of cardiac mortality. Here we review our current understanding of the cross-talk between inflammaging and cardiomyocytes in T2D cardiomyopathy. We discuss potential mechanisms of metabolic convergence between cell types which, we hypothesize, might tip the balance between resolution of the inflammation versus adverse cardiac metabolic remodelling in T2D cardiomyopathy. A better understanding of the multiple biological paradigms leading to T2D cardiomyopathy including the immunosenescence associated with inflammaging will provide a powerful target for successful therapeutic interventions.</p>
C1 [Henson, Sian M.] Ctr Translat Med & Therapeut, London, England.
   [Aksentijevic, Dunja] Ctr Biochem Pharmacol, London, England.
   [Aksentijevic, Dunja] Queen Mary Univ London, Barts & London Sch Med & Dent, Ctr Inflammat & Therapeut Innovat, William Harvey Res Inst, London, England.
C3 University of London; Queen Mary University London
RP Henson, SM (corresponding author), Ctr Translat Med & Therapeut, London, England.; Aksentijevic, D (corresponding author), Ctr Biochem Pharmacol, London, England.; Aksentijevic, D (corresponding author), Queen Mary Univ London, Barts & London Sch Med & Dent, Ctr Inflammat & Therapeut Innovat, William Harvey Res Inst, London, England.
EM d.aksentijevic@qmul.ac.uk; s.henson@qmul.ac.uk
OI Henson, Sian/0000-0003-1893-4912
FU Wellcome Trust [221604/Z/20/Z]; British Heart Foundation Accelerator
   Award [AA/18/5/34222]; Diabetes UK Grant [19/0005973]; Barts Charity
   Grant [MRC 0215]; SH Barts and the London Charity [MGU 0536]; Diabetes
   UK [19/0006057]; Wellcome Trust [221604/Z/20/Z] Funding Source: Wellcome
   Trust
FX DA Wellcome Trust (221604/Z/20/Z), British Heart Foundation Accelerator
   Award (AA/18/5/34222), Diabetes UK Grant (19/0005973), Barts Charity
   Grant (MRC 0215), SH Barts and the London Charity (MGU 0536), Diabetes
   UK (19/0006057).
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NR 133
TC 16
Z9 16
U1 0
U2 10
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD OCT 7
PY 2021
VL 12
AR 716517
DI 10.3389/fphar.2021.716517
PG 14
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA WM0LQ
UT WOS:000710787200001
PM 34690759
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Köhrle, J
AF Koehrle, Josef
TI Selenium in Endocrinology - Selenoprotein-Related Diseases, Population
   Studies, and Epidemiological Evidence
SO ENDOCRINOLOGY
LA English
DT Review
DE selenoprotein; thyroid hormone; diabetes; adrenals; musculoskeletal
   apparatus; gonads; biomarker; oxidative stress
ID RETICULUM-RESIDENT SELENOPROTEINS; KASHIN-BECK DISEASE;
   GLUTATHIONE-PEROXIDASE; CHONDROGENIC DIFFERENTIATION; METABOLIC
   SYNDROME; THYROID-HORMONES; BONE TURNOVER; DEFICIENCY; SUPPLEMENTATION;
   EXPRESSION
AB Selenium (Se), apart from iodine, iron, and calcium, is one of the nutrient-derived key elements strongly affecting the endocrine system. However, no specific hormonal "feedback" regulation for Se status has yet been identified, in contrast to the finetuned hormone network regulating Ca2+ and phosphate balance or hepcidin-related iron status. Since its discovery as an essential trace element, the effects of Se excess or deficiency on the endocrine system or components of the hypothalamic-pituitary-periphery feedback circuits, the thyroid hormone axis, glucoregulatory and adrenal hormones, male and female gonads, the musculoskeletal apparatus, and skin have been identified. Analysis of the Se status in the blood or via validated biomarkers such as the hepatically derived selenoprotein P provides valuable diagnostic insight and a rational basis for decision making on required therapeutic or preventive supplementation of risk groups or patients. Endocrine-related epidemiological and interventional evidence linking Se status to beneficial or potentially adverse actions of selected selenoproteins mediating most of the (patho-) physiological effects are discussed in this mini-review. Autoimmune thyroid disease, diabetes and obesity, male fertility, as well as osteoporosis are examples for which observational or interventional studies have indicated Se effects. The currently prevailing concept relating Se and selenoproteins to "oxidative stress;' reactive oxygen species, radical hypotheses, and related strategies of pharmacological approaches based on various selenium compounds will not be the focus. The crucial biological function of several selenoproteins in cellular redox-regulation and specific enzyme reactions in endocrine pathways will be addressed and put in clinical perspective.
C1 [Koehrle, Josef] Charite Univ Med Berlin, Freie Univ Berlin, Humboldt Univ Berlin, Inst Expt Endokrinol, Hessische Str 3-4,Vorderhaus,4OG, D-10115 Berlin, Germany.
   [Koehrle, Josef] Berlin Inst Hlth, Hessische Str 3-4,Vorderhaus,4OG, D-10115 Berlin, Germany.
C3 Berlin Institute of Health; Free University of Berlin; Humboldt
   University of Berlin; Charite Universitatsmedizin Berlin; Berlin
   Institute of Health
RP Köhrle, J (corresponding author), Charite Univ Med Berlin, Freie Univ Berlin, Humboldt Univ Berlin, Inst Expt Endokrinol, Hessische Str 3-4,Vorderhaus,4OG, D-10115 Berlin, Germany.; Köhrle, J (corresponding author), Berlin Inst Hlth, Hessische Str 3-4,Vorderhaus,4OG, D-10115 Berlin, Germany.
EM josef.koehrle@charite.de
RI Köhrle, Josef/AAH-6438-2020
OI Kohrle, Josef/0000-0002-9187-9078
FU German Research Foundation (DFG) Priority Program "SPP
   1629-ThyroidTransAct" [KO 922/16-1/2]; EU Horizon 2020 Programme
   [825161]
FX This work was supported by the German Research Foundation (DFG) Priority
   Program "SPP 1629-ThyroidTransAct" (grant No. KO 922/16-1/2) and the EU
   Horizon 2020 Programme (grant No. 825161).
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NR 120
TC 33
Z9 33
U1 0
U2 34
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0013-7227
EI 1945-7170
J9 ENDOCRINOLOGY
JI Endocrinology
PD FEB
PY 2021
VL 162
IS 2
AR bqaa228
DI 10.1210/endocr/bqaa228
PG 14
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA PQ4UU
UT WOS:000606541800014
PM 33382424
OA Bronze
DA 2025-06-11
ER

PT J
AU Caira, S
   Iannelli, A
   Sciarrillo, R
   Picariello, G
   Renzone, G
   Scaloni, A
   Addeoe, P
AF Caira, Simonetta
   Iannelli, Antonio
   Sciarrillo, Rosaria
   Picariello, Gianluca
   Renzone, Giovanni
   Scaloni, Andrea
   Addeoe, Pietro
TI Differential representation of liver proteins in obese human subjects
   suggests novel biomarkers and promising targets for drug development in
   obesity
SO JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
LA English
DT Article
DE Obesity; human liver proteome; protein biomarkers; oxidative stress;
   metabolic syndrome
ID HIGH-FAT DIET; HUMAN HEPATOCELLULAR-CARCINOMA; CARBONIC-ANHYDRASE
   INHIBITORS; ACID-BINDING PROTEIN; OXIDATIVE STRESS; HEPATIC STEATOSIS;
   MITOCHONDRIAL DYSFUNCTION; PROTEOMIC ANALYSIS; ADIPOSE-TISSUE; RAT-LIVER
AB The proteome of liver biopsies from human obese (O) subjects has been compared to those of nonobese (NO) subjects using two-dimensional gel electrophoresis (2-DE). Differentially represented proteins were identified by matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry (MS)-based peptide mass fingerprinting (PMF) and nanoflow-liquid chromatography coupled to electrospray-tandem mass spectrometry (nLC-ESI-MS/MS). Overall, 61 gene products common to all of the liver biopsies were identified within 65 spots, among which 25 ones were differently represented between O and NO subjects. In particular, over-representation of short-chain acyl-CoA dehydrogenase, Delta(3,5)-Delta(2,4) dienoyl-CoA isomerase, acetyl-CoA acetyltransferase, glyoxylate reductase/hydroxypyruvate reductase, fructose-biphosphate aldolase B, peroxiredoxin I, protein DJ-1, catalase, alpha- and beta-hemoglobin subunits, 3-mercaptopyruvate S-transferase, calreticulin, aminoacylase 1, phenazine biosynthesis-like domain-containing protein and a form of fatty acid-binding protein, together with downrepresentation of glutamate dehydrogenase, glutathione S-transferase A1, S-adenosylmethionine synthase 1A and a form of apolipoprotein A-I, was associated with the obesity condition. Some of these metabolic enzymes and antioxidant proteins have already been identified as putative diagnostic markers of liver dysfunction in animal models of steatosis or obesity, suggesting additional investigations on their role in these syndromes. Their differential representation in human liver was suggestive of their consideration as obesity human biomarkers and for the development of novel antiobesity drugs.
C1 [Caira, Simonetta; Renzone, Giovanni; Scaloni, Andrea] CNR, Prote & Mass Spectrometry Lab, ISPAAM, I-80147 Naples, Italy.
   [Iannelli, Antonio] CHU Nice, Dept Chirurg Digest, Nice, France.
   [Sciarrillo, Rosaria] Univ Sannio, Dipartimento Sci & Tecnol, Benevento, Italy.
   [Picariello, Gianluca] CNR, Inst Food Sci, Avellino, Italy.
   [Addeoe, Pietro] Univ Strasbourg, Hop Univ Strasbourg, Serv Chirurg Hepat Pancreat Biliaire & Transplant, Hop Hautepierre,Pole Pathol Digest Hepat & Transp, Strasbourg, France.
C3 Consiglio Nazionale delle Ricerche (CNR); Istituto Per Il Sistema
   Produzione Animale In Ambiente Mediterraneo (ISPAAM-CNR); CHU Nice;
   University of Sannio; Consiglio Nazionale delle Ricerche (CNR); Istituto
   di Scienze dell' Alimentazione (ISA-CNR); CHU Strasbourg; Universites de
   Strasbourg Etablissements Associes; Universite de Strasbourg
RP Caira, S (corresponding author), CNR, Prote & Mass Spectrometry Lab, ISPAAM, I-80147 Naples, Italy.
EM simonetta.caira@ispaam.cnr.it
RI Iannelli, Antonio/E-6521-2012; Caira, Simonetta/AAK-6327-2021; RENZONE,
   GIOVANNI/B-5650-2015
OI SCIARRILLO, Rosaria/0000-0002-8844-3281; ADDEO,
   Pietro/0000-0003-0046-7973; RENZONE, GIOVANNI/0000-0003-3621-6391;
   Iannelli, Antonio/0000-0002-1611-071X; Scaloni,
   Andrea/0000-0001-9362-8515; Caira, Simonetta/0000-0002-5868-4607;
   PICARIELLO, Gianluca/0000-0003-1290-1239
FU public or private institutions
FX This work was performed without a specific funding support by public or
   private institutions.
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NR 72
TC 16
Z9 18
U1 0
U2 39
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1475-6366
EI 1475-6374
J9 J ENZYM INHIB MED CH
JI J. Enzym. Inhib. Med. Chem.
PY 2017
VL 32
IS 1
BP 672
EP 682
DI 10.1080/14756366.2017.1292262
PG 11
WC Biochemistry & Molecular Biology; Chemistry, Medicinal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
GA ES5LA
UT WOS:000399579300008
PM 28274171
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Al-Mallah, MH
   Keteyian, SJ
   Brawner, CA
   Whelton, S
   Blaha, MJ
AF Al-Mallah, Mouaz H.
   Keteyian, Steven J.
   Brawner, Clinton A.
   Whelton, Seamus
   Blaha, Michael J.
TI Rationale and Design of the Henry Ford ExercIse Testing Project (The FIT
   Project)
SO CLINICAL CARDIOLOGY
LA English
DT Article
ID CARDIOVASCULAR-DISEASE MORTALITY; ALL-CAUSE MORTALITY; CARDIORESPIRATORY
   FITNESS; PHYSICAL-ACTIVITY; METABOLIC SYNDROME; HEART-DISEASE;
   HEALTHY-MEN; BIG DATA; RISK; PREVENTION
AB Although physical fitness is a powerful prognostic marker in clinical medicine, most cardiovascular population-based studies do not have a direct measurement of cardiorespiratory fitness. In line with the call from the National Heart Lung and Blood Institute for innovative, low-cost, epidemiologic studies leveraging electronic medical record (EMR) data, we describe the rationale and design of the Henry Ford ExercIse Testing Project (The FIT Project). The FIT Project is unique in its combined use of directly measured clinical exercise data retrospective collection of medical history and medication treatment data at the time of the stress test, retrospective supplementation of supporting clinical data using the EMR and administrative databases and epidemiologic follow-up for cardiovascular events and total mortality via linkage with claims files and the death registry. The FIT Project population consists of 69 885 consecutive physician-referred patients (mean age, 54 +/- 10 years; 54% males) who underwent Bruce protocol treadmill stress testing at Henry Ford Affiliated Hospitals between 1991 and 2009. Patients were followed for the primary outcomes of death, myocardial infarction, and need for coronary revascularization. The median estimated peak metabolic equivalent (MET) level was 10, with 17% of the patients having a severely reduced fitness level (METs < 6). At the end of the follow-up duration, 15.9%, 5.6%, and 6.7% of the patients suffered all-cause mortality, myocardial infarction, or revascularization procedures, respectively. The FIT Project is the largest study of physical fitness to date. With its use of modern electronic clinical epidemiologic techniques, it is poised to answer many clinically relevant questions related to exercise capacity and prognosis.
C1 [Al-Mallah, Mouaz H.; Keteyian, Steven J.; Brawner, Clinton A.] Henry Ford Hosp, Div Cardiovasc Med, Detroit, MI 48202 USA.
   [Al-Mallah, Mouaz H.] Wayne State Univ, Dept Med, Detroit, MI 48202 USA.
   [Al-Mallah, Mouaz H.] King Abdul Aziz Cardiac Ctr, Cardiac Imaging Dept, Riyadh, Saudi Arabia.
   [Whelton, Seamus; Blaha, Michael J.] Johns Hopkins Sch Med, Ciccarone Ctr Prevent Heart Dis, Baltimore, MD USA.
C3 Henry Ford Health System; Henry Ford Hospital; Wayne State University;
   Johns Hopkins University; Johns Hopkins Medicine
RP Al-Mallah, MH (corresponding author), Wayne State Univ, Dept Med, Detroit, MI 48202 USA.
EM mouaz74@gmail.com
RI Brawner, Clinton/K-6859-2019
OI Al-Mallah, Mouaz/0000-0003-2348-0484; Brawner, Clinton
   A./0000-0002-1705-6620
CR American Heart Association, 1972, EX TEST TRAIN APP HL
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NR 30
TC 89
Z9 89
U1 0
U2 9
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0160-9289
EI 1932-8737
J9 CLIN CARDIOL
JI Clin. Cardiol.
PD AUG
PY 2014
VL 37
IS 8
BP 456
EP 461
DI 10.1002/clc.22302
PG 6
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA AN3ZW
UT WOS:000340528400001
PM 25138770
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Huang, CL
   Wu, YW
   Wu, CC
   Lin, L
   Wu, YC
   Hsu, PY
   Jong, YS
   Yang, WS
AF Huang, Chi-Lun
   Wu, Yen-Wen
   Wu, Chih-Cheng
   Lin, Lin
   Wu, Yu-Chin
   Hsu, Pei-Ying
   Jong, Yuh-Shiun
   Yang, Wei-Shiung
TI Association between serum adipocyte fatty-acid binding protein
   concentrations, left ventricular function and myocardial perfusion
   abnormalities in patients with coronary artery disease
SO CARDIOVASCULAR DIABETOLOGY
LA English
DT Article
DE Adipocyte fatty-acid binding protein; Coronary artery disease;
   Single-photon emission computed tomography
ID INCIDENT HEART-FAILURE; METABOLIC SYNDROME; ENDOTHELIAL-CELLS;
   APOLIPOPROTEIN-E; ATHEROSCLEROSIS; OBESITY; AP2; CARDIOMYOPATHY;
   ADIPONECTIN; DYSFUNCTION
AB Background: Adipokines, including adipocyte fatty acid-binding protein (A-FABP), have been demonstrated to be involved in the pathogenesis of atherosclerosis. In the present study, we investigated the association of circulating A-FABP level with severity of myocardial perfusion abnormalities analyzed by Tl-201 dipyridamole single-photon emission computed tomography.
   Methods: A total of 170 patients with coronary artery disease (CAD) from cardiovascular clinics were enrolled in the study. Serum A-FABP levels, echocardiography, and stress myocardial perfusion imaging results were analyzed.
   Results: Compared with the patients with mild CAD (summed stress score [SSS] <= 8), those with moderate to severe CAD (SSS > 8) had significantly higher A-FABP concentrations. However, the difference was attenuated in the subgroup of patients with heart failure. In the correlation analyses, A-FABP level was correlated with age, body mass index, waist circumference, levels of creatinine, fasting glucose, high-sensitivity C-reactive protein, N-terminal pro-brain natriuretic peptide, adiponectin, and several echocardiographic parameters, including left ventricular ejection fraction. Multivariate logistic regression analysis demonstrated that the A-FABP level was not only associated with higher SSS (odds ratio, 1.30; 95% confidence interval [CI], 1.01-1.69; P = 0.048), but also an independent risk factor for heart failure (odds ratio 2.71, 95% CI, 1.23-5.94; P = 0.013).
   Conclusions: Serum A-FABP levels not only were associated with myocardial perfusion abnormalities and left ventricular function, but also predicted the presence of heart failure in our patients with CAD.
C1 [Huang, Chi-Lun; Jong, Yuh-Shiun] Taoyuan Gen Hosp, Dept Internal Med, Tao Yuan, Taiwan.
   [Huang, Chi-Lun; Wu, Yen-Wen; Yang, Wei-Shiung] Natl Taiwan Univ Hosp, Dept Internal Med, Taipei 100, Taiwan.
   [Wu, Yen-Wen] Natl Taiwan Univ Hosp, Dept Nucl Med, Taipei 100, Taiwan.
   [Huang, Chi-Lun; Yang, Wei-Shiung] Natl Taiwan Univ, Coll Med, Grad Inst Clin Med, Taipei 100, Taiwan.
   [Wu, Yen-Wen] Far Eastern Mem Hosp, Div Cardiovasc, Med Ctr, Dept Nucl Med & Cardiol, New Taipei City, Taiwan.
   [Wu, Yen-Wen] Natl Yang Ming Univ, Sch Med, Taipei 112, Taiwan.
   [Wu, Chih-Cheng; Lin, Lin] Natl Taiwan Univ Hosp, Hsin Chu branch, Dept Internal Med, Hsinchu, Taiwan.
   [Wu, Yu-Chin] Natl Taiwan Univ Hosp, Hsin Chu branch, Dept Nucl Med, Hsinchu, Taiwan.
   [Hsu, Pei-Ying] Natl Taiwan Univ Hosp, Yun Lin Branch, Dept Nucl Med, Douliou City, Taiwan.
C3 National Taiwan University; National Taiwan University Hospital;
   National Taiwan University; National Taiwan University Hospital;
   National Taiwan University; Far Eastern Memorial Hospital; National Yang
   Ming Chiao Tung University; National Taiwan University; National Taiwan
   University Hospital; National Taiwan University; National Taiwan
   University Hospital; National Taiwan University; National Taiwan
   University Hospital
RP Wu, YW (corresponding author), Natl Taiwan Univ Hosp, Dept Internal Med, Taipei 100, Taiwan.
EM wuyw0502@gmail.com; wsyang@ntu.edu.tw
RI Liu, Chun-Yu/I-4358-2015; Li, Tsai-Chung/P-2052-2015
OI Lin, Lin/0000-0001-6246-8803; WU, CHIH-CHENG/0000-0002-9690-6573; WU,
   YU-CHIN/0000-0002-1751-461X; YANG, WEI-SHIUNG/0000-0001-5087-373X; WU,
   YEN-WEN/0000-0003-1520-1166
CR [Anonymous], 2005, J AM COLL CARDIOL, V46, P1144, DOI 10.1016/j.jacc.2005.07.012
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NR 34
TC 31
Z9 33
U1 0
U2 10
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1475-2840
J9 CARDIOVASC DIABETOL
JI Cardiovasc. Diabetol.
PD JUL 17
PY 2013
VL 12
AR 105
DI 10.1186/1475-2840-12-105
PG 7
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism
GA 193ZF
UT WOS:000322599300001
PM 23866022
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Jiang, F
   Lim, HK
   Morris, MJ
   Prior, L
   Velkoska, E
   Wu, X
   Dusting, GJ
AF Jiang, Fan
   Lim, Han K.
   Morris, Margaret J.
   Prior, Larissa
   Velkoska, Elena
   Wu, Xiao
   Dusting, Gregory J.
TI Systemic upregulation of NADPH oxidase in diet-induced obesity in rats
SO REDOX REPORT
LA English
DT Article
DE Obesity; NADPH oxidase; Oxidative stress; Blood pressure; Adiponectin
ID REDUCES OXIDATIVE STRESS; VASCULAR SMOOTH-MUSCLE; ANGIOTENSIN-II;
   NAD(P)H OXIDASE; METABOLIC SYNDROME; ENDOTHELIAL DYSFUNCTION; SUPEROXIDE
   GENERATION; CHRONIC HYPERTENSION; ADIPOSE-TISSUE; NEUROPEPTIDE-Y
AB Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase is upregulated in a variety of tissues in obesity. It is still unclear as to whether NADPH oxidase upregulation in a specific tissue is part of a systemic response. Here we analyzed the expression pattern of NADPH oxidase in vascular, adipose, and kidney tissues in a rat model of diet-induced obesity. After weaning, rats were fed either a normal or high-fat diet for 12 weeks. The high-fat diet resulted in 20% increased body weight. In the aorta, Nox4 expression was increased by three-fold in obese rats. Upregulations of p22phox and p47phox in adipose, and Nox4, p22phox, and p47phox in kidney were observed in obesity. Marked increases in plasma leptin and insulin were observed, with more modest changes in adiponectin in obese rats. The average systolic blood pressure in the obese group was 11 mmHg higher than that of lean rats (P < 0.005). There was a significant correlation between blood pressure and aortic Nox4 expression (P < 0.01). In cultured vascular smooth muscle cells, adiponectin reduced the expression of Nox4 in a protein kinase A-dependent manner. Our results suggest that upregulation of NADPH oxidase in multiple tissues during obesity appears to be a systemic response. At least in vitro, adiponectin may have a protective antioxidant role by suppressing vascular NADPH oxidase expression. The association between NADPH oxidase Nox4 expression in the vasculature and the elevated blood pressure in obesity requires further investigation.
C1 [Jiang, Fan] Shandong Univ, Qilu Hosp, Minist Educ, Key Lab Cardiovasc Remodeling & Funct Res, Jinan 250012, Shandong, Peoples R China.
   [Jiang, Fan] Shandong Univ, Qilu Hosp, Minist Hlth, Jinan 250012, Shandong, Peoples R China.
   [Jiang, Fan; Lim, Han K.] Univ Melbourne, OBrien Inst, Melbourne, Vic, Australia.
   [Jiang, Fan; Lim, Han K.] Univ Melbourne, Dept Surg, Melbourne, Vic, Australia.
   [Morris, Margaret J.] Univ New S Wales, Dept Pharmacol, Sydney, NSW, Australia.
   [Prior, Larissa] Univ Melbourne, Dept Pharmacol, Melbourne, Vic, Australia.
   [Velkoska, Elena; Wu, Xiao] Univ Melbourne, Dept Med, Melbourne, Vic, Australia.
   [Dusting, Gregory J.] Univ Melbourne, Ctr Eye Res Australia, Melbourne, Vic, Australia.
C3 Ministry of Education - China; Shandong University; Shandong University;
   O'Brien Institute; University of Melbourne; University of Melbourne;
   University of New South Wales Sydney; University of Melbourne;
   University of Melbourne; Centre for Eye Research Australia; University
   of Melbourne
RP Jiang, F (corresponding author), Shandong Univ, Qilu Hosp, Minist Educ, Key Lab Cardiovasc Remodeling & Funct Res, 107 W Wenhua Rd, Jinan 250012, Shandong, Peoples R China.
EM fjiang@sdu.edu.cn
RI Jiang, Fan/B-7753-2013; Morris, Margaret/J-4285-2013
OI Morris, Margaret/0000-0003-2285-5117
FU National Health and Medical Research Council (NHMRC) of Australia;
   National Heart Foundation of Australia; National 973 Basic Research
   Program of China [2010CB732605]; NSFC [81070164]
FX The authors thank Nancy Guo for technical assistance in the real-time
   PCR assay. This study was partially supported by Project Grants from the
   National Health and Medical Research Council (NHMRC) of Australia,
   Grants-in-Aid from the National Heart Foundation of Australia, National
   973 Basic Research Program of China (2010CB732605), and NSFC (grant
   81070164). G.J.D. receives an NHMRC Principal Research Fellowship.
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NR 39
TC 55
Z9 60
U1 0
U2 18
PU MANEY PUBLISHING
PI LEEDS
PA STE 1C, JOSEPHS WELL, HANOVER WALK, LEEDS LS3 1AB, W YORKS, ENGLAND
SN 1351-0002
J9 REDOX REP
JI Redox Rep.
PD NOV
PY 2011
VL 16
IS 6
BP 223
EP 229
DI 10.1179/174329211X13049558293713
PG 7
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 866QU
UT WOS:000298397100001
PM 22195989
OA Green Published
DA 2025-06-11
ER

PT J
AU Garaulet, M
   Corbalán-Tutau, MD
   Madrid, JA
   Baraza, JC
   Parnell, LD
   Lee, YC
   Ordovas, JM
AF Garaulet, Maria
   Dolores Corbalan-Tutau, M.
   Madrid, Juan A.
   Baraza, Juan C.
   Parnell, Laurence D.
   Lee, Yu-Chi
   Ordovas, Jose M.
TI PERIOD2 Variants Are Associated with Abdominal Obesity,
   Psycho-Behavioral Factors and Attrition in the Dietary Treatment of
   Obesity
SO JOURNAL OF THE AMERICAN DIETETIC ASSOCIATION
LA English
DT Article
ID WEIGHT-LOSS; DIURNAL PREFERENCE; METABOLIC SYNDROME; GENETIC-VARIANTS;
   EATING BEHAVIORS; POPULATION; POLYMORPHISMS
AB The purpose of this research was to test for association between polymorphisms in the circadian clock related gene PERIOD2 (PER2) and attrition in patients prone to withdrawal from a behavioral weight-reduction program based on the Mediterranean diet. A total of 454 overweight/obese participants (women=380, men=74), aged 20 to 65 years, who attended outpatient clinics specializing in obesity between January and December 2008, were studied. Anthropometric, biochemical, and dietary-intake variables were analyzed. Effectiveness of the program was assessed, and a questionnaire of barriers to weight loss was considered. Multivariate analysis and logistic regression models were performed. Results indicate that PER2 polymorphisms rs2304672C>G and rs4663302C>T were associated with abdominal obesity (P<0.05). Participants who withdrew from treatment were significantly more obese and had more barriers to lose weight (P<0.05). They also displayed a lower likelihood of planning eating in advance and experiencing stress with dieting than those who completed treatment. Frequency of rs4663307 minor allele was significantly greater in withdrawers than in those who successfully completed treatment (P<0.05). Logistic regression analysis showed that rs2304672 C>G minor allele carriers had a greater probability of dropping out, displaying extreme snacking, experiencing stress with dieting, eating when bored, and skipping breakfast than noncarriers. PER2 is implicated in attrition in weight-loss treatment and may modulate eating-behavior related phenotypes. These findings could represent a step toward personalized health care and nutrition based on a combination of genotyping and psycho-behavioral characterization. J Am Diet Assoc. 2010;110:917-921.
C1 [Garaulet, Maria] Univ Murcia, Dept Physiol, Fac Biol, E-30100 Murcia, Spain.
   [Ordovas, Jose M.] Tufts Univ, Sch Med, Jean Mayer USDA, Human Nutr Res Ctr Aging,Nutr & Genom Lab, Boston, MA 02111 USA.
C3 University of Murcia; United States Department of Agriculture (USDA);
   Tufts University
RP Garaulet, M (corresponding author), Univ Murcia, Dept Physiol, Fac Biol, Campus Espinardo S-N, E-30100 Murcia, Spain.
EM garaulet@um.es
RI Garaulet, Marta/K-6625-2014; madrid, juan/K-5322-2017; Ordovas,
   Jose/B-8727-2013
OI Garaulet, Marta/0000-0002-4066-3509; Ordovas, Jose/0000-0002-7581-5680;
   Madrid, Juan Antonio/0000-0002-9286-1371
FU Government of Education, Science, and Research of Murcia [BIO/FFA
   07/01-0004]; Spanish Government of Science and Innovation
   [AGL2008-01655/ALI]; National Institute of Diabetes and Digestive and
   Kidney Diseases [DK075030]; US Department of Agriculture Research
   Service [53-K06-5-10, 58-1950-9-001]
FX This work was supported the Government of Education, Science, and
   Research of Murcia (Project BIO/FFA 07/01-0004), The Spanish Government
   of Science and Innovation (projects AGL2008-01655/ALI), National
   Institute of Diabetes and Digestive and Kidney Diseases grant no.
   DK075030, and by contracts 53-K06-5-10 and 58-1950-9-001 from the US
   Department of Agriculture Research Service.
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   2007, REV ESP OBES     MAR, P7
NR 26
TC 82
Z9 87
U1 0
U2 13
PU AMER DIETETIC ASSOC
PI CHICAGO
PA 120 S RIVERSIDE PLZ, STE 2000, CHICAGO, IL 60606-6995 USA
SN 0002-8223
J9 J AM DIET ASSOC
JI J. Am. Diet. Assoc.
PD JUN
PY 2010
VL 110
IS 6
BP 917
EP 921
DI 10.1016/j.jada.2010.03.017
PG 5
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 607OQ
UT WOS:000278515200017
PM 20497782
OA Green Accepted
DA 2025-06-11
ER

PT J
AU IL'Yasova, D
   Ivanova, A
   Morrow, JD
   Cesari, M
   Pahor, M
AF IL'Yasova, Dora
   Ivanova, Anastasia
   Morrow, Jason D.
   Cesari, Matteo
   Pahor, Marco
TI Correlation between two markers of inflammation, serum C-reactive
   protein and interleukin 6, and indices of oxidative stress in patients
   with high risk of cardiovascular disease
SO BIOMARKERS
LA English
DT Article
DE biological markers; oxidative stress; inflammation; epidemiology
ID BETA-CAROTENE; VITAMIN-E; PLASMA-CONCENTRATIONS; ANTIOXIDANT VITAMINS;
   METABOLIC SYNDROME; ALPHA-TOCOPHEROL; HEALTH; F-2-ISOPROSTANES;
   ISOPROSTANES; PERFORMANCE
AB As evidence of the involvement of inflammation and oxidative damage in pathogenesis of age-related chronic diseases is growing, epidemiologists need to develop measures of both conditions to study their relationships in human populations. One way of searching for appropriate biomarkers is to examine correlations between different inflammatory markers and oxidative indices. We examined cross-sectional correlations between two inflammatory markers, serum C-reactive protein (CRP) and interleukin (IL)-6, and three oxidative indices, plasma levels of alpha-tocopherol and beta-carotene, and urinary levels of 2,3-dinor-5,6-dihydro-15-F-2t-isoprostane (F-2-IsoP), in 60 individuals at high risk of cardiovascular disease. Correlations between the biomarkers were examined graphically and using the Pearson correlation coefficient. No correlation was found between plasma levels of alpha-tocopherol and either of the inflammatory markers. Plasma beta-carotene inversely correlated with IL-6 (r=-0.46, p=0.0002) and CRP (r=-0.41, p=0.001). Although urinary F2-IsoP did not correlate with IL-6, this biomarker positively correlated with CRP (r=0.31, p=0.002). As only urinary F-2-IsoP levels have been validated against known oxidative assaults, their positive association with CRP levels is interpreted as evidence of an interconnection between low-level inflammation and oxidative status. Urinary levels of F-2-IsoP and serum levels of CRP represent appropriate biomarkers for future studies of inflammation and oxidative status in humans.
C1 [IL'Yasova, Dora] Duke Comprehens Canc Ctr, Durham, NC 27710 USA.
   [Ivanova, Anastasia] Univ N Carolina, Sch Publ Hlth, Chapel Hill, NC USA.
   [Morrow, Jason D.] Vanderbilt Univ, Med Ctr, Nashville, TN USA.
   [Cesari, Matteo; Pahor, Marco] Univ Florida, Dept Aging & Geriat Res, Gainesville, FL USA.
C3 Duke University; University of North Carolina; University of North
   Carolina Chapel Hill; Vanderbilt University; State University System of
   Florida; University of Florida
RP IL'Yasova, D (corresponding author), Duke Comprehens Canc Ctr, 2424 Erwin Rd,Hock Bldg, Ste 602,Box 2949, Durham, NC 27710 USA.
EM dora.ilyasova@duke.edu
RI Cesari, Matteo/A-4649-2008
OI Cesari, Matteo/0000-0002-0348-3664
FU NCI NIH HHS [CA77839] Funding Source: Medline; NIA NIH HHS
   [P30-AG-021332-02] Funding Source: Medline; NIDDK NIH HHS [DK48831]
   Funding Source: Medline; NIEHS NIH HHS [ES13125] Funding Source:
   Medline; NIGMS NIH HHS [GM15431] Funding Source: Medline
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NR 51
TC 46
Z9 51
U1 0
U2 3
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1354-750X
EI 1366-5804
J9 BIOMARKERS
JI Biomarkers
PY 2008
VL 13
IS 1
BP 41
EP 51
DI 10.1080/13547500701617708
PG 11
WC Biotechnology & Applied Microbiology; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Toxicology
GA 250QJ
UT WOS:000252314800003
PM 17852073
DA 2025-06-11
ER

PT J
AU Arai, N
   Masuzaki, H
   Tanaka, T
   Ishii, T
   Yasue, S
   Kobayashi, N
   Tomita, T
   Noguchi, M
   Kusakabe, T
   Fujikura, J
   Ebihara, K
   Hirata, M
   Hosoda, K
   Hayashi, T
   Sawai, H
   Minokoshi, Y
   Nakao, K
AF Arai, N.
   Masuzaki, H.
   Tanaka, T.
   Ishii, T.
   Yasue, S.
   Kobayashi, N.
   Tomita, T.
   Noguchi, M.
   Kusakabe, T.
   Fujikura, J.
   Ebihara, K.
   Hirata, M.
   Hosoda, K.
   Hayashi, T.
   Sawai, H.
   Minokoshi, Y.
   Nakao, K.
TI Ceramide and adenosine 5′-monophosphate-activated protein kinase are two
   novel regulators of 11β-hydroxysteroid dehydrogenase type 1 expression
   and activity in cultured preadipocytes
SO ENDOCRINOLOGY
LA English
DT Article
ID CCAAT/ENHANCER-BINDING PROTEINS; HEPATIC INSULIN SENSITIVITY; FATTY-ACID
   OXIDATION; ADIPOSE-TISSUE; METABOLIC SYNDROME;
   5-AMINOIMIDAZOLE-4-CARBOXAMIDE RIBONUCLEOSIDE; RECEPTOR ANTAGONIST;
   INDUCED APOPTOSIS; VISCERAL OBESITY; GLUCOSE-UPTAKE
AB Increased activity of intracellular glucocorticoid reactivating enzyme, 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1) in obese adipose tissue contributes to adipose dysfunction. As recent studies have highlighted a potential role of preadipocytes in adipose dysfunction, we tested the hypothesis that a variety of metabolic stress mediated by ceramide or AMP-activated protein kinase (AMPK) would regulate 11 beta-HSD1 in preadipocytes. The present study is the first to show that 1) expression of 11 beta-HSD1 in 3T3-L1 preadipocytes was robustly induced when cells were treated with cell-permeable ceramide analogue C-2 ceramide, bacterial sphingomyelinase, and sphingosine 1-phosphate, 2) 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR)-induced activation of AMPK augmented the expression and enzyme activity of 11 beta-HSD1, and 3) these results were reproduced in human preadipocytes. We demonstrate for the first time that C-2 ceramide and AICAR markedly induced the expression of CCAAT/enhancer-binding protein (C/EBP) beta and its binding to 11 beta-HSD1 promoter. Transient knockdown of C/EBP beta protein by small interfering RNA markedly attenuated the expression of 11 beta-HSD1 induced by C-2 ceramide or AICAR. The present study provides novel evidence that ceramide- and AMPK-mediated signaling pathways augment the expression and activity of 11 beta-HSD1 in preadipocytes by way of C/EBP beta, thereby highlighting a novel, metabolic stress-related regulation of 11 beta-HSD1 in a cell-specific manner.
C1 Kyoto Univ, Grad Sch Med, Dept Med & Clin Sci, Div Endocrinol & Metab,Sakyo Ku, Kyoto 6068507, Japan.
   Kyoto Univ, Grad Sch Human & Environm Studies, Dept Human Coexistence, Kyoto 6068501, Japan.
   Osaka Dent Univ, Dept Internal Med, Osaka 5731121, Japan.
   Natl Inst Physiol Sci, Dept Dev Physiol, Aichi 4448585, Japan.
C3 Kyoto University; Kyoto University; National Institutes of Natural
   Sciences (NINS) - Japan; National Institute for Physiological Sciences
   (NIPS)
RP Masuzaki, H (corresponding author), Kyoto Univ, Grad Sch Med, Dept Med & Clin Sci, Div Endocrinol & Metab,Sakyo Ku, 54 Shogoin Kawahara Cho, Kyoto 6068507, Japan.
EM hiroaki@kuhp.kyoto-u.ac.jp
RI Kusakabe, Toru/G-2234-2010; Sawai, Hideaki/S-4602-2019; Fujikura,
   Junji/AAR-2684-2020
OI Minokoshi, Yasuhiko/0000-0002-7119-4805; hayashi,
   Tatsuya/0000-0001-7600-4735
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NR 63
TC 24
Z9 27
U1 0
U2 1
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0013-7227
EI 1945-7170
J9 ENDOCRINOLOGY
JI Endocrinology
PD NOV
PY 2007
VL 148
IS 11
BP 5268
EP 5277
DI 10.1210/en.2007-0349
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 224JT
UT WOS:000250444000017
PM 17702848
OA hybrid
DA 2025-06-11
ER

PT J
AU Faria, RVD
   Duarte, MS
   Nogueira, JD
   Gregorio, BM
   Romana-Souza, B
AF Faria, Regina Viana de Carvalho
   Duarte, Matheus Silva
   Nogueira, Jeane de Souza
   Gregorio, Bianca Martins
   Romana-Souza, Bruna
TI Nrf2 activation by hydroxytyrosol and dimethyl fumarate ameliorates skin
   tissue repair in high-fat diet-fed mice by promoting M2 macrophage
   polarization and normalizing inflammatory response and oxidative damage
SO JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
LA English
DT Article
DE dimethyl fumarate; hydroxytyrosol; Nrf2; obesity; wound healing
ID INSULIN-RESISTANCE; METABOLIC SYNDROME; OBESITY; STRESS
AB Hydroxytyrosol (HT) or dimethyl fumarate (DMF), activators of nuclear factor erythroid 2-related factor 2 (Nrf2), may reduce obesity in high-fat diet (HFD)-fed animals; nevertheless, the role of these activators on skin tissue repair of HFD-fed animals was not reported. This study investigated whether HT or DMF could improve skin wound healing of HFD-fed obese animals. Mice were fed with an HFD, treated with HT or DMF, and full-thickness skin wounds were created. Macrophages isolated from control and obese animals were treated in vitro with HT. DMF, but not HT, reduced the body weight of HFD-fed mice. Collagen deposition and wound closure were improved by HT or DMF in HFD-fed animals. HT or DMF increased anti-inflammatory macrophage phenotype and protein Nrf2 levels in wounds of HFD-fed mice. Lipid peroxidation and protein tumor necrosis factor-alpha levels were reduced by HT or DMF in wounds of HFD-fed animals. In in vitro, HT stimulated Nrf2 activation in mouse macrophages isolated from obese animals. In conclusion, HT or DMF improves skin wound healing of HFD-fed mice by reducing oxidative damage and inflammatory response. HT or DMF may be used as a therapeutic strategy to improve the skin healing process in individuals with obesity.
   The administration of hydroxytyrosol (HT) or dimethyl fumarate (DMF) promotes the activation of the nuclear factor erythroid 2-related factor (Nrf2) signaling pathway, which reduces the oxidative stress and inflammation accelerating skin wound healing.image
C1 [Faria, Regina Viana de Carvalho; Duarte, Matheus Silva; Romana-Souza, Bruna] Univ Estado Rio De Janeiro, Histol & Embryol Dept, Rio De Janeiro, RJ, Brazil.
   [Nogueira, Jeane de Souza] Univ Estado Rio De Janeiro, Lab Histocompatibil & Cryopreservat, Rio De Janeiro, RJ, Brazil.
   [Gregorio, Bianca Martins] Univ Estado Rio De Janeiro, Urogenital Res Unit, Rio De Janeiro, RJ, Brazil.
   [Romana-Souza, Bruna] Univ Estado Rio De Janeiro, Dept Histol & Embryol, 381 Marechal Rondon Ave, BR-20950003 Rio De Janeiro, RJ, Brazil.
C3 Universidade do Estado do Rio de Janeiro; Universidade do Estado do Rio
   de Janeiro; Universidade do Estado do Rio de Janeiro; Universidade do
   Estado do Rio de Janeiro
RP Romana-Souza, B (corresponding author), Univ Estado Rio De Janeiro, Dept Histol & Embryol, 381 Marechal Rondon Ave, BR-20950003 Rio De Janeiro, RJ, Brazil.
EM bruna.romana.souza@uerj.br
RI Gregório, Bianca/O-4359-2014; Romana-Souza, Bruna/ABI-7446-2020;
   Romana-Souza, Bruna/O-9104-2017
OI Romana-Souza, Bruna/0000-0001-5665-8694
FU Fundao Carlos Chagas Filho de Amparo Pesquisa do Estado do Rio de
   Janeiro [211.176/2019, 211.809/2021]; Carlos Chagas Filho Foundation for
   Research Support in the Rio de Janeiro State (FAPERJ)
FX The authors acknowledge Dr Zhenlong Chen for your suggestions and
   comments on this paper. Carlos Chagas Filho Foundation for Research
   Support in the Rio de Janeiro State (FAPERJ) [grant numbers:
   211.176/2019 and 211.809/2021] supported this study.
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NR 48
TC 2
Z9 2
U1 1
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1095-6670
EI 1099-0461
J9 J BIOCHEM MOL TOXIC
JI J. Biochem. Mol. Toxicol.
PD FEB
PY 2024
VL 38
IS 2
AR e23652
DI 10.1002/jbt.23652
PG 12
WC Biochemistry & Molecular Biology; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Toxicology
GA FN3L0
UT WOS:001146467700001
PM 38348708
DA 2025-06-11
ER

PT J
AU Rowicka, G
   Klemarczyk, W
   Ambroszkiewicz, J
   Strucinska, M
   Kawiak-Jawor, E
   Weker, H
   Chelchowska, M
AF Rowicka, Grazyna
   Klemarczyk, Witold
   Ambroszkiewicz, Jadwiga
   Strucinska, Malgorzata
   Kawiak-Jawor, Ewa
   Weker, Halina
   Chelchowska, Magdalena
TI Assessment of Oxidant and Antioxidant Status in Prepubertal Children
   following Vegetarian and Omnivorous Diets
SO ANTIOXIDANTS
LA English
DT Article
DE lacto-ovo-vegetarian diet; children; reduced glutathione; oxidized
   glutathione; total oxidant capacity; total antioxidant capacity
ID OXIDATIVE STRESS; CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME;
   RISK-FACTORS; VITAMIN-B-12; BIOMARKERS; MARKERS; HEALTH; INFLAMMATION;
   ASSOCIATION
AB Oxidant-antioxidant balance is crucial for maintaining one's health, and the diet is possibly one of the most important factors affecting this balance. Therefore, the aim of this study was to determine the oxidant-antioxidant balance in children on a lacto-ovo-vegetarian diet. The study was conducted between January 2020 and December 2021. The concentrations of total oxidant capacity (TOC), total antioxidant capacity (TAC), reduced (GSH), and oxidized (GSSG) glutathione, as well as C-reactive protein (CRP) and calprotectin were measured in serum samples of 72 healthy prepubertal children (32 vegetarians and 40 omnivores). The oxidative stress index (OSI) and the GSH/GSSG ratio (R-index) were calculated. Children on a vegetarian diet had significantly lower median values of TOC, GSH, and GSSG, and higher TAC compared with the omnivores. OSI was significantly lower in vegetarians, while R-index, as well as median values of CRP and calprotectin did not differ between both groups of children. Significant negative correlations were observed between TOC and TAC levels in the whole group of children and in vegetarians. GSH and GSSG levels correlated positively in the groups of vegetarians, omnivores, and in all the children. There were significant positive correlations between TOC and GSH, as well as GSSG levels in all the studied groups of children. Our study results suggest that the vegetarian model of nutrition allows to maintain the oxidant-antioxidant balance in the serum of prepubertal children.
C1 [Rowicka, Grazyna; Klemarczyk, Witold; Strucinska, Malgorzata; Weker, Halina] Inst Mother & Child Hlth, Dept Nutr, PL-01211 Warsaw, Poland.
   [Ambroszkiewicz, Jadwiga; Chelchowska, Magdalena] Inst Mother & Child Hlth, Dept Screening Tests & Metab Diagnost, PL-01211 Warsaw, Poland.
   [Kawiak-Jawor, Ewa] Inst Org & Management Ind ORGMASZ, Lukasiewicz Res Network, PL-00879 Warsaw, Poland.
RP Rowicka, G (corresponding author), Inst Mother & Child Hlth, Dept Nutr, PL-01211 Warsaw, Poland.
EM grazyna.rowicka@imid.med.pl
RI Strucińska, Małgorzata/V-8653-2019; Kawiak, Ewa/KHV-9176-2024; Weker,
   Halina/N-3714-2018; Ambroszkiewicz, Jadwiga/W-1516-2018; Rowicka,
   Grazyna/N-7180-2018; Chelchowska, Magdalena/Y-2951-2018
OI Ambroszkiewicz, Jadwiga/0000-0001-7320-7561; Rowicka,
   Grazyna/0000-0002-0560-9435; Chelchowska, Magdalena/0000-0002-6174-6813;
   Kawiak-Jawor, Ewa/0000-0002-3995-2178
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NR 80
TC 8
Z9 9
U1 0
U2 5
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD MAR
PY 2023
VL 12
IS 3
AR 682
DI 10.3390/antiox12030682
PG 14
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA A1MQ4
UT WOS:000952843200001
PM 36978931
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Park, J
   Lyles, RH
   Bauer-Wu, S
AF Park, Jeanie
   Lyles, Robert H.
   Bauer-Wu, Susan
TI Mindfulness meditation lowers muscle sympathetic nerve activity and
   blood pressure in African-American males with chronic kidney disease
SO AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE
   PHYSIOLOGY
LA English
DT Article
DE muscle sympathetic nerve activity; mindfulness meditation; chronic renal
   insufficiency
ID RANDOMIZED CONTROLLED-TRIAL; ARTERIAL BAROREFLEX SENSITIVITY; STRESS
   REDUCTION; CARDIOVASCULAR-DISEASE; TRANSCENDENTAL-MEDITATION; METABOLIC
   SYNDROME; RENAL-DISEASE; BETA-BLOCKERS; RISK-FACTOR; HEART
AB Mindfulness meditation (MM) is a stress-reduction technique that may have real biological effects on hemodynamics but has never previously been tested in chronic kidney disease (CKD) patients. In addition, the mechanisms underlying the potential blood pressure (BP)-lowering effects of MM are unknown. We sought to determine whether MM acutely lowers BP in CKD patients, and whether these hemodynamic changes are mediated by a reduction in sympathetic nerve activity. In 15 hypertensive African-American (AA) males with CKD, we conducted a randomized, crossover study in which participants underwent 14 min of MM or 14 min of BP education (control intervention) during two separate random-order study visits. Muscle sympathetic nerve activity (MSNA), beat-to-beat arterial BP, heart rate (HR), and respiratory rate (RR) were continuously measured at baseline and during each intervention. A subset had a third study visit to undergo controlled breathing (CB) to determine whether a reduction in RR alone was sufficient in exacting hemodynamic changes. We observed a significantly greater reduction in systolic BP, diastolic BP, mean arterial pressure, and HR, as well as a significantly greater reduction in MSNA, during MM compared with the control intervention. Participants had a significantly lower RR during MM; however, in contrast to MM, CB alone did not reduce BP, HR, or MSNA. MM acutely lowers BP and HR in AA males with hypertensive CKD, and these hemodynamic effects may be mediated by a reduction in sympathetic nerve activity. RR is significantly lower during MM, but CB alone without concomitant meditation does not acutely alter hemodynamics or sympathetic activity in CKD.
C1 [Park, Jeanie] Emory Univ, Sch Med, Div Renal, Dept Med, Atlanta, GA 30322 USA.
   [Park, Jeanie] Dept Vet Affairs Med Ctr, Res Serv Line, Decatur, GA USA.
   [Lyles, Robert H.] Emory Univ, Rollins Sch Publ Hlth, Dept Biostat & Bioinformat, Atlanta, GA 30322 USA.
   [Bauer-Wu, Susan] Univ Virginia, Sch Nursing, Charlottesville, VA 22903 USA.
C3 Emory University; Emory University; Rollins School Public Health;
   University of Virginia
RP Park, J (corresponding author), Emory Univ, Sch Med, Div Renal, 1639 Pierce Dr,WMB 338, Atlanta, GA 30322 USA.
EM jeanie.park@emory.edu
FU NCATS NIH HHS [UL1 TR000454] Funding Source: Medline; NCRR NIH HHS [UL1
   RR025008] Funding Source: Medline; NHLBI NIH HHS [K23 HL-098744, K23
   HL098744] Funding Source: Medline
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NR 57
TC 43
Z9 49
U1 0
U2 47
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0363-6119
EI 1522-1490
J9 AM J PHYSIOL-REG I
JI Am. J. Physiol.-Regul. Integr. Comp. Physiol.
PD JUL 1
PY 2014
VL 307
IS 1
BP R93
EP R101
DI 10.1152/ajpregu.00558.2013
PG 9
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA AL1YG
UT WOS:000338921900011
PM 24829497
OA Green Published
DA 2025-06-11
ER

PT J
AU Genchi, VA
   Cignarelli, A
   Sansone, A
   Yannas, D
   Dalla Valentina, L
   Livraghi, DR
   Spaggiari, G
   Santi, D
AF Genchi, Valentina Annamaria
   Cignarelli, Angelo
   Sansone, Andrea
   Yannas, Dimitri
   Dalla Valentina, Leonardo
   Livraghi, Daniele Renda
   Spaggiari, Giorgia
   Santi, Daniele
TI Understanding the Role of Alcohol in Metabolic Dysfunction and Male
   Infertility
SO METABOLITES
LA English
DT Review
DE alcohol; testosterone; hypogonadism; infertility
ID HORMONE-BINDING GLOBULIN; PITUITARY-GONADAL AXIS; INDUCED LIVER-INJURY;
   ETHANOL STIMULATES GLYCOGENOLYSIS; OXIDATIVE STRESS; SEMEN QUALITY;
   REPRODUCTIVE HORMONES; POSSIBLE MECHANISM; BETA-ENDORPHIN;
   MALE-FERTILITY
AB Purpose: Over the past 40-50 years, demographic shifts and the obesity epidemic have coincided with significant changes in lifestyle habits, including a rise in excessive alcohol consumption. This increase in alcohol intake is a major public health concern due to its far-reaching effects on human health, particularly on metabolic processes and male reproductive function. This narrative review focuses on the role of alcohol consumption in altering metabolism and impairing testicular function, emphasizing the potential damage associated with both acute and chronic alcohol intake. Conclusion: Chronic alcohol consumption has been shown to disrupt liver function, impair lipid metabolism, and dysregulate blood glucose levels, contributing to the development of obesity, metabolic syndrome, and related systemic diseases. In terms of male reproductive health, alcohol can significantly affect testicular function by lowering testosterone levels, reducing sperm quality, and impairing overall fertility. The extent of these effects varies, depending on the frequency, duration, and intensity of alcohol use, with chronic and abusive consumption posing greater risks. The complexity of alcohol's impact is further compounded by individual variability and the interaction with other lifestyle factors such as diet, stress, and physical activity. Despite growing concern, research on alcohol's effects remains inconclusive, with significant discrepancies across studies regarding the definition and reporting of alcohol consumption. These inconsistencies highlight the need for more rigorous, methodologically sound research to better understand how alcohol consumption influences metabolic and reproductive health. Ultimately, a clearer understanding is essential for developing targeted public health interventions, particularly in light of rising alcohol use, demographic changes, and the ongoing obesity crisis.
C1 [Genchi, Valentina Annamaria; Cignarelli, Angelo] Univ Bari Aldo Moro, Dept Precis & Regenerat Med, I-70121 Bari, Italy.
   [Genchi, Valentina Annamaria; Cignarelli, Angelo] Univ Bari Aldo Moro, Ionian Area Sect Internal Med Endocrinol Androl &, I-70121 Bari, Italy.
   [Sansone, Andrea; Yannas, Dimitri] Univ Roma Tor Vergata, Chair Endocrinol & Med Sexol ENDOSEX, Dept Syst Med, Tower E South,Room E 413,Via Montpellier 1, I-00133 Rome, Italy.
   [Dalla Valentina, Leonardo; Livraghi, Daniele Renda; Santi, Daniele] Univ Modena & Reggio Emilia, Dept Biomed Metab & Neural Sci, I-41121 Modena, Italy.
   [Dalla Valentina, Leonardo; Livraghi, Daniele Renda; Spaggiari, Giorgia; Santi, Daniele] Azienda Osped Univ Modena, Dept Med Specialties, Unit Endocrinol, I-41125 Modena, Italy.
C3 Universita degli Studi di Bari Aldo Moro; Universita degli Studi di Bari
   Aldo Moro; University of Rome Tor Vergata; Universita di Modena e Reggio
   Emilia; Universita di Modena e Reggio Emilia; Universita di Modena e
   Reggio Emilia Hospital
RP Spaggiari, G (corresponding author), Azienda Osped Univ Modena, Dept Med Specialties, Unit Endocrinol, I-41125 Modena, Italy.
EM giorgia.spaggiari87@gmail.com; daniele.santi@unimore.it
RI Spaggiari, Giorgia/S-4186-2019; Genchi, Valentina/AFU-5050-2022;
   Cignarelli, Angelo/I-6353-2013; Sansone, Andrea/H-6451-2016; Santi,
   Daniele/J-7005-2018
OI Sansone, Andrea/0000-0002-1210-2843; Cignarelli,
   Angelo/0000-0001-6477-9031; Spaggiari, Giorgia/0000-0002-7089-7330;
   Genchi, Valentina Annamaria/0000-0001-8188-9638; Santi,
   Daniele/0000-0001-6607-7105
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NR 183
TC 1
Z9 1
U1 6
U2 6
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2218-1989
J9 METABOLITES
JI Metabolites
PD NOV
PY 2024
VL 14
IS 11
AR 626
DI 10.3390/metabo14110626
PG 25
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA N6R6F
UT WOS:001365590100001
PM 39590862
OA gold
DA 2025-06-11
ER

PT J
AU Qiao, J
   Wu, YW
   Ren, YZ
AF Qiao, Jie
   Wu, Yiwen
   Ren, Yuezhong
TI The impact of a high fat diet on bones: potential mechanisms
SO FOOD & FUNCTION
LA English
DT Review
ID MESENCHYMAL STEM-CELLS; MARROW ADIPOSE-TISSUE; TUMOR-NECROSIS-FACTOR;
   GUT MICROBIOTA; INDUCED OBESITY; OSTEOCLAST DIFFERENTIATION; OXIDATIVE
   STRESS; CORTICAL BONE; MINERAL DENSITY; AKKERMANSIA-MUCINIPHILA
AB A high-fat diet (HFD) is defined as a diet that contains lipids that account for more than 30% of the total energy intake, and current research has documented cases with intakes as high as 45% and 60%. There is a view that patients who have a tendency to consume a HFD are more susceptible to various kinds of diseases, including osteoporosis, metabolic syndrome, coronary heart disease, and cancer. Thus, hypotheses have been proposed that a HFD may serve as a significant risk factor for bone loss and osteoporosis. A plethora of studies has suggested a relationship between a HFD and bone health. Moreover, high fat has a vital effect on the bone structure and bone health, and intestinal flora imbalances and intestine barrier deterioration, inflammation, oxidative stress, adipokine changes, and bone marrow fat tissue (BMFT) accumulation are thought to be potential mechanisms. Most research has demonstrated that a HFD diminishes bone mineral density and bone microstructure. Some studies, however, showed that a HFD contributes to achieving peak bone mass, which is associated with weight gain. As diet is modifiable, lifestyle changes and medication can help bone improvement, as well as alleviating bone loss associated with a HFD. This review aims to give a comprehensive understanding of the relationship between a HFD and bone health, which might provide strategies to improve bone health by varying daily dietary components and building a healthy lifestyle. We also hope that further treatments for diet-related bone loss can be put forward.
C1 [Qiao, Jie; Ren, Yuezhong] Zhejiang Univ, Dept Endocrinol & Metab, Affiliated Hosp 2, Sch Med, 88 Jiefang Rd, Hangzhou 310009, Zhejiang, Peoples R China.
   [Wu, Yiwen] Zhejiang Univ, Dept Neurosurg, Ningbo Hosp, Sch Med, Ningbo 315010, Zhejiang, Peoples R China.
C3 Zhejiang University; Zhejiang University
RP Ren, YZ (corresponding author), Zhejiang Univ, Dept Endocrinol & Metab, Affiliated Hosp 2, Sch Med, 88 Jiefang Rd, Hangzhou 310009, Zhejiang, Peoples R China.
EM renyuez@zju.edu.cn
RI wu, yiwen/KLY-8477-2024
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NR 132
TC 36
Z9 39
U1 4
U2 59
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PD FEB 7
PY 2021
VL 12
IS 3
BP 963
EP 975
DI 10.1039/d0fo02664f
PG 13
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA QH1ST
UT WOS:000618057700003
PM 33443523
DA 2025-06-11
ER

PT J
AU Scoditti, E
   Carpi, S
   Massaro, M
   Pellegrino, M
   Polini, B
   Carluccio, MA
   Wabitsch, M
   Verri, T
   Nieri, P
   De Caterina, R
AF Scoditti, Egeria
   Carpi, Sara
   Massaro, Marika
   Pellegrino, Mariangela
   Polini, Beatrice
   Carluccio, Maria Annunziata
   Wabitsch, Martin
   Verri, Tiziano
   Nieri, Paola
   De Caterina, Raffaele
TI Hydroxytyrosol Modulates Adipocyte Gene and miRNA Expression Under
   Inflammatory Condition
SO NUTRIENTS
LA English
DT Article
DE adipocyte; exosome; gene expression; hydroxytyrosol; inflammation;
   insulin resistance; extra virgin olive oil; miRNA; obesity; polyphenol
ID VIRGIN OLIVE OIL; NF-KAPPA-B; VASCULAR ENDOTHELIAL-CELLS; ADIPOSE-TISSUE
   INFLAMMATION; DIET-INDUCED OBESITY; INSULIN-RESISTANCE; MEDITERRANEAN
   DIET; PHENOLIC-COMPOUNDS; METABOLIC SYNDROME; OXIDATIVE STRESS
AB Chronic inflammation of the adipose tissue (AT) is a major contributor to obesity-associated cardiometabolic complications. The olive oil polyphenol hydroxytyrosol (HT) contributes to Mediterranean diet cardiometabolic benefits through mechanisms still partially unknown. We investigated HT (1 and 10 mu mol/L) effects on gene expression (mRNA and microRNA) related to inflammation induced by 10 ng/mL tumor necrosis factor (TNF)-alpha in human Simpson-Golabi-Behmel Syndrome (SGBS) adipocytes. At real-time PCR, HT significantly inhibited TNF-alpha-induced mRNA levels, of monocyte chemoattractant protein-1, C-X-C Motif Ligand-10, interleukin (IL)-1 beta, IL-6, vascular endothelial growth factor, plasminogen activator inhibitor-1, cyclooxygenase-2, macrophage colony-stimulating factor, matrix metalloproteinase-2, Cu/Zn superoxide dismutase-1, and glutathione peroxidase, as well as surface expression of intercellular adhesion molecule-1, and reverted the TNF-alpha-mediated inhibition of endothelial nitric oxide synthase, peroxisome proliferator-activated receptor coactivator-1 alpha, and glucose transporter-4. We found similar effects in adipocytes stimulated by macrophage-conditioned media. Accordingly, HT significantly counteracted miR-155-5p, miR-34a-5p, and let-7c-5p expression in both cells and exosomes, and prevented NF-kappa B activation and production of reactive oxygen species. HT can therefore modulate adipocyte gene expression profile through mechanisms involving a reduction of oxidative stress and NF-kappa B inhibition. By such mechanisms, HT may blunt macrophage recruitment and improve AT inflammation, preventing the deregulation of pathways involved in obesity-related diseases.
C1 [Scoditti, Egeria; Massaro, Marika; Carluccio, Maria Annunziata] Natl Res Council CNR, Inst Clin Physiol IFC, I-73100 Lecce, Italy.
   [Carpi, Sara; Polini, Beatrice; Nieri, Paola] Univ Pisa, Dept Pharm, Lab Mol Pharmacol, I-56126 Pisa, Italy.
   [Pellegrino, Mariangela; Verri, Tiziano] Univ Salento, Dept Biol & Environm Sci & Technol DISTEBA, Lab Appl Physiol, I-73100 Lecce, Italy.
   [Wabitsch, Martin] Univ Ulm, Dept Pediat & Adolescent Med, Div Pediat Endocrinol Diabet & Obes, D-89075 Ulm, Germany.
   [De Caterina, Raffaele] Pisa Univ Hosp, Cardiol Div, I-56126 Pisa, Italy.
C3 Consiglio Nazionale delle Ricerche (CNR); Istituto di Fisiologia Clinica
   (IFC-CNR); University of Pisa; University of Salento; Ulm University;
   University of Pisa; Azienda Ospedaliero Universitaria Pisana
RP De Caterina, R (corresponding author), Pisa Univ Hosp, Cardiol Div, I-56126 Pisa, Italy.
EM egeria.scoditti@ifc.cnr.it; sara.carpi@unipi.it;
   marika.massaro@ifc.cnr.it; mariangela_pellegrino@yahoo.it;
   beatrice.polini@farm.unipi.it; maria.carluccio@ifc.cnr.it;
   Martin.Wabitsch@uniklinik-ulm.de; tiziano.verri@unisalento.it;
   paola.nieri@farm.unipi.it; raffaele.decaterina@unipi.it
RI Nieri, Paola/K-5814-2016; carpi, sara/AAG-7683-2021; Carluccio,
   Maria/AAO-1683-2020; Verri, Tiziano/K-1442-2013; De Caterina,
   Raffaele/K-3857-2016; Massaro, Marika/HNI-1375-2023; POLINI,
   Beatrice/AAH-3375-2021; SCODITTI, EGERIA/J-8609-2016
OI Massaro, Marika/0000-0001-6124-5077; CARLUCCIO, MARIA
   ANNUNZIATA/0000-0002-8307-1829; POLINI, Beatrice/0000-0002-2664-6091;
   Carpi, Sara/0000-0002-3291-9009; SCODITTI, EGERIA/0000-0003-2753-8487
FU G. d'Annunzio Foundation, Chieti, Italy
FX This research was supported by the G. d'Annunzio Foundation, Chieti,
   Italy, through private funding attributed to R.D.C.
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NR 142
TC 42
Z9 44
U1 0
U2 18
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD OCT
PY 2019
VL 11
IS 10
AR 2493
DI 10.3390/nu11102493
PG 29
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA JP4HG
UT WOS:000498227300233
PM 31627295
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Kawamoto, R
   Ninomiya, D
   Kumagi, T
AF Kawamoto, Ryuichi
   Ninomiya, Daisuke
   Kumagi, Teru
TI Handgrip Strength Is Positively Associated with Mildly Elevated Serum
   Bilirubin Levels among Community-Dwelling Adults
SO TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE
LA English
DT Article
DE confounding factor; handgrip strength; muscle strength; oxidative
   stress; serum total bilirubin
ID GRIP STRENGTH; CARDIOVASCULAR-DISEASE; OXIDATIVE STRESS; ANTIOXIDANT;
   HEALTH; MORTALITY; EXERCISE; RISK; RAT
AB Handgrip strength (HGS) is a useful measure of health-related quality of life and general muscle strength. Serum total bilirubin (T-B) may present potential beneficial effects in preventing oxidative changes which are associated with a risk of metabolic syndrome and the development of cardiovascular disease. Limited information is available regarding whether HGS is an independent confounding factor for serum T-B. The study participants were 214 men aged 71 +/- 8 (mean +/- standard deviation) years and 302 women aged 71 +/- 7 years that were enrolled consecutively from among paticipants aged >= 50 years through an annual check-up process. We evaluated the relationship between serum T-B and confounding factors within each sex. HGS related significantly with serum T-B in both men (r = 0.156, p = 0.023) and women (r = 0.173, p = 0.003). Multiple linear regression analysis showed that in men, HGS (beta = 0.173) as well as smoking status (beta = -0.147), exercise habit (beta = 0.138), low-density lipoprotein cholesterol (beta = 0.146), and hemoglobin A1c (HbA1c) (beta = -0.198) were significantly and independently associated with serum T-B. In women, HGS = 0.159) as well as smoking status (beta = -0.116), high-density lipoprotein cholesterol (beta = 0.159), and HbA1c (beta = -0.161) were significantly and independently associated with serum T-B. Multivariate adjusted serum T-B levels were significantly lower in subjects with the lowest HGS level in both sexes. Increased HGS is strongly associated with increased serum T-B, independent of confounding factors in both sexes.
C1 [Kawamoto, Ryuichi; Ninomiya, Daisuke; Kumagi, Teru] Ehime Univ, Grad Sch Med, Dept Community Med, Toon, Ehime, Japan.
   [Kawamoto, Ryuichi; Ninomiya, Daisuke] Seiyo Municipal Nomura Hosp, Dept Internal Med, 9-53 Nomura,Nomura Cho, Seiyo, Ehime 7971212, Japan.
C3 Ehime University
RP Kawamoto, R (corresponding author), Seiyo Municipal Nomura Hosp, Dept Internal Med, 9-53 Nomura,Nomura Cho, Seiyo, Ehime 7971212, Japan.
EM tykawamo@m.ehime-u.ac.jp
RI Kumagi, Teru/AAS-7427-2021
OI Kumagi, Teru/0000-0002-2292-7750
FU Foundation for Development of Community
FX This study was supported, in part, by a grant-in-aid from the Foundation
   for the Development of the Community (2016).
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NR 28
TC 19
Z9 19
U1 0
U2 1
PU TOHOKU UNIV MEDICAL PRESS
PI SENDAI
PA 2-1, SEIRYO-MACHI, AOBA-KU, SENDAI, MIYAGI 980-8575, JAPAN
SN 0040-8727
EI 1349-3329
J9 TOHOKU J EXP MED
JI Tohoku J. Exp. Med.
PD NOV
PY 2016
VL 240
IS 3
BP 221
EP 226
DI 10.1620/tjem.240.221
PG 6
WC Medicine, General & Internal; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Research & Experimental Medicine
GA EE5XP
UT WOS:000389683200006
PM 27867155
OA gold
DA 2025-06-11
ER

PT J
AU Ibero-Baraibar, I
   Abete, I
   Navas-Carretero, S
   Massis-Zaid, A
   Martinez, JA
   Zulet, MA
AF Ibero-Baraibar, I.
   Abete, I.
   Navas-Carretero, S.
   Massis-Zaid, A.
   Martinez, J. A.
   Zulet, M. A.
TI Oxidised LDL levels decreases after the consumption of ready-to-eat
   meals supplemented with cocoa extract within a hypocaloric diet
SO NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
LA English
DT Article
DE Cocoa extract; Oxidative stress; oxLDL; Obesity; Middle-aged
ID HDL-CHOLESTEROL CONCENTRATIONS; LOW-DENSITY-LIPOPROTEIN;
   LIPID-PEROXIDATION; METABOLIC SYNDROME; OXIDATIVE STRESS;
   BLOOD-PRESSURE; RICH COCOA; CHOCOLATE; OBESE; METAANALYSIS
AB Background and aims: Cocoa flavanols are recognised by their favourable antioxidant and vascular effects. This study investigates the influence on health of the daily consumption of ready-to-eat meals supplemented with cocoa extract within a hypocaloric diet, on middle-aged overweight/obese subjects.
   Methods and results: Fifty healthy male and female middle-aged volunteers [57.26 +/- 5.24 years and body mass index (BMI) 30.59 +/- 2.33 kg/m(2)] were recruited to participate in a 4 week randomised, parallel and double-blind study. After following 3 days on a low-polyphenol diet, 25 volunteers received meals supplemented with 1.4 g of cocoa extract (645.3 mg of polyphenols) and the other 25 participants received control meals, within a 15% energy restriction diet. On the 4th week of intervention individuals in both dietary groups improved (p < 0.05) anthropometric, body composition, blood pressure and blood biochemical measurements. Oxidised LDL cholesterol (oxLDL), showed a higher reduction (p = 0.030) in the cocoa group. Moreover, myeloperoxidase (MPO) levels decreased only in the cocoa supplemented group (p = 0.007). Intercellular Adhesion Molecule-1 (sICAM-1) decreased significantly in both groups, while Vascular Cell Adhesion Molecule-1 (sVCAM-1) did not present differences after the 4 weeks of intervention. Interestingly, cocoa intake showed a different effect by gender, presenting more beneficial effects in men.
   Conclusions: The consumption of cocoa extract as part of ready-to-eat meals and within a hypocaloric diet improved oxidative status (oxLDL) in middle-aged subjects, being most remarkable in males. (C) 2013 Elsevier B. V. All rights reserved.
C1 [Ibero-Baraibar, I.; Abete, I.; Navas-Carretero, S.; Massis-Zaid, A.; Martinez, J. A.; Zulet, M. A.] Univ Navarra, Dept Nutr Food Sci & Physiol, E-31080 Pamplona, Spain.
   [Navas-Carretero, S.; Martinez, J. A.; Zulet, M. A.] Carlos III Hlth Res Inst, CIBERobn, Madrid, Spain.
C3 University of Navarra; CIBER - Centro de Investigacion Biomedica en Red;
   CIBEROBN
RP Martinez, JA (corresponding author), Univ Navarra, Dept Nutr Food Sci & Physiol, C Irunlarrea 1, Navarra 31008, Spain.
EM jalfmtz@unav.es
RI Martinez Hernandez, J Alfredo/K-8709-2014; Navas-Carretero,
   Santiago/L-2918-2015; Zulet, M. Angeles/H-1317-2017; Abete,
   Itziar/H-4827-2017
OI Martinez Hernandez, J Alfredo/0000-0001-5218-6941; Navas-Carretero,
   Santiago/0000-0002-5163-2230; Zulet, M. Angeles/0000-0002-3926-0892;
   Ibero-Baraibar, Idoia/0000-0003-0091-8068; Abete,
   Itziar/0000-0002-6475-5387
FU CDTI within CENIT Program (Industrial Research diets and food with
   specific characteristics for elderly -SENIFOOD); University of Navarra
   [LE/97]; CIBERobn (Physiopathology of Obesity and Nutrition, Carlos III
   Health Research Institute)
FX The authors acknowledge the financial support of the CDTI within CENIT
   Program (Industrial Research diets and food with specific
   characteristics for elderly -SENIFOOD) as well as the University of
   Navarra LE/97 and CIBERobn (Physiopathology of Obesity and Nutrition,
   Carlos III Health Research Institute). Thanks are given to the physician
   (Martinez de Morentin, BE), the nurse (Perez, S), and the technician
   (Ciaurriz, V). Also, the authors thank Tutti Pasta S. A. (Navarra,
   Spain) for supplying studied products and CNTA (Navarra, Spain) for
   analysing the composition of meals. Idoia Ibero-Baraibar appreciates the
   scholarship of Navarra University (ADA).
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NR 29
TC 49
Z9 50
U1 0
U2 23
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0939-4753
EI 1590-3729
J9 NUTR METAB CARDIOVAS
JI Nutr. Metab. Carbiovasc. Dis.
PD APR
PY 2014
VL 24
IS 4
BP 416
EP 422
DI 10.1016/j.numecd.2013.09.017
PG 7
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism; Nutrition
   & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism;
   Nutrition & Dietetics
GA AD7EH
UT WOS:000333424300010
PM 24462367
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Erickson, MA
   Hansen, K
   Banks, WA
AF Erickson, Michelle A.
   Hansen, Kim
   Banks, William A.
TI Inflammation-induced dysfunction of the low-density lipoprotein
   receptor-related protein-1 at the blood-brain barrier: Protection by the
   antioxidant N-acetylcysteine
SO BRAIN BEHAVIOR AND IMMUNITY
LA English
DT Article
DE Amyloid beta; Alzheimer's disease; Neuroinflammation; Oxidative stress;
   Lipopolysaccharide; LRP-1; Pgp; N-acetylcysteine
ID AMYLOID-BETA-PEPTIDE; MICROVASCULAR ENDOTHELIAL-CELLS; P-GLYCOPROTEIN
   FUNCTION; NECROSIS-FACTOR-ALPHA; ACETYL-L-CYSTEINE; OXIDATIVE STRESS;
   ALZHEIMERS-DISEASE; COGNITIVE IMPAIRMENT; SYSTEMIC INFLAMMATION;
   METABOLIC SYNDROME
AB Impairment in two blood-brain barrier (BBB) efflux transporters, p-glycoprotein (Pgp) and low-density lipoprotein receptor-related protein-1 (LRP-1) are thought to contribute to the progression of Alzheimer's disease (AD) by resulting in the brain accumulation of their substrate amyloid beta peptide (A beta). The initial cause of impaired efflux, however, is unknown. We have shown that induction of systemic inflammation by intraperitoneal administration of lipopolysaccharide impairs the efflux of A beta from the brain, suggesting that systemic inflammation could be one such initiator. In this study, we determined whether pre-administration of the antioxidant N-aceytlcysteine (Nac) has a protective effect against LPS-induced A beta transporter dysfunction. Our findings were that Nac protected against LPS-induced A beta transport dysfunction at the BBB through an LRP-1-dependent and Pgp-independent mechanism. This was associated with Nac exerting antioxidant effects in the periphery but not the brain, despite an increased rate of entry of Nac into the brain following LPS. We also found that Nac pre-administration resulted in lower blood levels of the cytokines and chemokines interferon-gamma, interleukin-10, CCL2, CCL4, and CCL5, but only lowered CCL4 in the cerebral cortex and hippocampus. Finally, we observed that hippocampal cytokine responses to LPS were decreased compared to cortex. These findings demonstrate a novel mechanism by which antioxidants prevent A beta accumulation in the brain caused by inflammation, and therefore protect against AD. (c) 2012 Elsevier Inc. All rights reserved.
C1 [Erickson, Michelle A.] St Louis Univ, Dept Physiol & Pharmacol, St Louis, MO 63103 USA.
   [Erickson, Michelle A.; Hansen, Kim; Banks, William A.] Vet Affairs Puget Sound Hlth Care Syst, GRECC, Seattle, WA USA.
   [Hansen, Kim; Banks, William A.] Univ Washington, Sch Med, Dept Internal Med, Div Gerontol & Geriatr Med, Seattle, WA USA.
C3 Saint Louis University; Geriatric Research Education & Clinical Center;
   US Department of Veterans Affairs; Veterans Health Administration (VHA);
   Vet Affairs Puget Sound Health Care System; University of Washington;
   University of Washington Seattle
RP Banks, WA (corresponding author), Bldg 1,Rm 810A,1660 Columbian Way, Seattle, WA 98108 USA.
EM mericks9@slu.edu; nesnah@washington.edu; wabanks1@uw.edu
RI Hansen, Kim/HKN-4416-2023; Banks, William/K-1330-2017; Erickson,
   Michelle/U-7754-2019; Erickson, Michelle/G-4815-2014
OI Erickson, Michelle/0000-0002-2575-1594
FU NIA NIH HHS [R01 AG029839] Funding Source: Medline
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NR 73
TC 80
Z9 88
U1 0
U2 28
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0889-1591
EI 1090-2139
J9 BRAIN BEHAV IMMUN
JI Brain Behav. Immun.
PD OCT
PY 2012
VL 26
IS 7
BP 1085
EP 1094
DI 10.1016/j.bbi.2012.07.003
PG 10
WC Immunology; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Neurosciences & Neurology; Psychiatry
GA 007PC
UT WOS:000308899600011
PM 22809665
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Anchimowicz, J
   Zielonka, P
   Jakiela, S
AF Anchimowicz, Julia
   Zielonka, Piotr
   Jakiela, Slawomir
TI Plant Secondary Metabolites as Modulators of Mitochondrial Health: An
   Overview of Their Anti-Oxidant, Anti-Apoptotic, and Mitophagic
   Mechanisms
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE plant secondary metabolites; alkaloids; terpenoids; polyphenols;
   saponins; mitochondrial dysfunction; cardiovascular diseases;
   neurodegenerative diseases; metabolic diseases; side effects
ID INDUCED OXIDATIVE STRESS; CARNOSIC ACID; MARSDENIA-TENACISSIMA;
   ASTRAGALOSIDE-IV; IN-VITRO; SOLUBILITY; INJURY; STABILITY; EXTRACT;
   BIOAVAILABILITY
AB Plant secondary metabolites (PSMs) are a diverse group of bioactive compounds, including flavonoids, polyphenols, saponins, and terpenoids, which have been recognised for their critical role in modulating cellular functions. This review provides a comprehensive analysis of the effects of PSMs on mitochondrial health, with particular emphasis on their therapeutic potential. Emerging evidence shows that these metabolites improve mitochondrial function by reducing oxidative stress, promoting mitochondrial biogenesis, and regulating key processes such as apoptosis and mitophagy. Mitochondrial dysfunction, a hallmark of many pathologies, including neurodegenerative disorders, cardiovascular diseases, and metabolic syndrome, has been shown to benefit from the protective effects of PSMs. Recent studies show that PSMs can improve mitochondrial dynamics, stabilise mitochondrial membranes, and enhance bioenergetics, offering significant promise for the prevention and treatment of mitochondrial-related diseases. The molecular mechanisms underlying these effects, including modulation of key signalling pathways and direct interactions with mitochondrial proteins, are discussed. The integration of PSMs into therapeutic strategies is highlighted as a promising avenue for improving treatment efficacy while minimising the side effects commonly associated with synthetic drugs. This review also highlights the need for future research to elucidate the specific roles of individual PSMs and their synergistic interactions within complex plant matrices, which may further optimise their therapeutic utility. Overall, this work provides valuable insights into the complex role of PSMs in mitochondrial health and their potential as natural therapeutic agents targeting mitochondrial dysfunction.
C1 [Anchimowicz, Julia; Zielonka, Piotr; Jakiela, Slawomir] Warsaw Univ Life Sci, Inst Biol, Dept Phys & Biophys, PL-02787 Warsaw, Poland.
C3 Warsaw University of Life Sciences
RP Jakiela, S (corresponding author), Warsaw Univ Life Sci, Inst Biol, Dept Phys & Biophys, PL-02787 Warsaw, Poland.
EM julia_anchimowicz@sggw.edu.pl; piotr_zielonka@sggw.edu.pl;
   slawomir_jakiela@sggw.edu.pl
RI Anchimowicz, Julia/LVA-1010-2024; Jakiela, Slawomir/G-5295-2011
OI Jakiela, Slawomir/0000-0003-1557-1650; Anchimowicz,
   Julia/0009-0002-7648-0197
FU National Science Centre, Poland [2019/34/E/ST4/00281]; Program SONATA
   BIS 9 of the National Science Centre, Poland
FX This research was supported by funding provided by the Program SONATA
   BIS 9 of the National Science Centre, Poland, Grant No.
   2019/34/E/ST4/00281.
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NR 243
TC 3
Z9 3
U1 12
U2 12
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD JAN
PY 2025
VL 26
IS 1
AR 380
DI 10.3390/ijms26010380
PG 34
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA R8A7C
UT WOS:001393614000001
PM 39796234
OA gold
DA 2025-06-11
ER

PT J
AU Salvolini, E
   Vignini, A
   Sabbatinelli, J
   Lucarini, G
   Pompei, V
   Sartini, D
   Cester, AM
   Ciavattini, A
   Mazzanti, L
   Emanuelli, M
AF Salvolini, Eleonora
   Vignini, Arianna
   Sabbatinelli, Jacopo
   Lucarini, Guendalina
   Pompei, Veronica
   Sartini, Davide
   Cester, Anna Maria
   Ciavattini, Andrea
   Mazzanti, Laura
   Emanuelli, Monica
TI Nitric oxide synthase and VEGF expression in full-term placentas of
   obese women
SO HISTOCHEMISTRY AND CELL BIOLOGY
LA English
DT Article
DE Nitric oxide synthase; Nitrotyrosine; Obese women; Placenta; Vascular
   endothelial growth factor
ID ENDOTHELIAL GROWTH-FACTOR; OXIDATIVE STRESS; MATERNAL OBESITY; METABOLIC
   SYNDROME; ANGIOGENESIS; PREGNANCY; COMPLICATIONS; DYSFUNCTION;
   INCREASES; WEIGHT
AB An adequate placental vascularization allows the proper development of the fetus and it is crucial for the gestational success. A number of factors regulate angiogenesis, including vascular endothelial growth factor (VEGF), which induces the synthesis of nitric oxide (NO), a potent vasodilator produced by three different nitric oxide synthase (NOS) isoforms. NO is essential to maintain a low vascular resistance in the fetoplacental circulation, although at high concentrations, it may combine with excess superoxide to produce peroxynitrite, which reacts with proteins giving rise to nitrotyrosine. Since obesity, whose incidence is increasing worldwide, is characterized by a low-grade inflammatory state and increased levels of oxidative and nitrative stress, both affecting placental function, our aim was to evaluate the expression of VEGF, eNOS, and iNOS in full-term placentas obtained from normal weight and pre-pregnancy obese women by means of immunohistochemistry and real-time PCR. Moreover, we assessed the NO levels and the nitrotyrosine immunoexpression in the same sample groups. Our results show a significantly higher immunohistochemical expression of VEGF and eNOS in the endothelium of placentas from obese women than in controls, whereas the immunoexpression of iNOS was comparable in the two groups. These data agree with those of the gene expression analysis, thus suggesting the possible existence of a compensatory mechanism for changes in placental blood flow associated with obesity. As concerns nitrotyrosine and NO levels, we observed a significant increase in placental tissue from obese women which may contribute to the development of metabolic and cardiovascular diseases both in the mother and the offspring.
C1 [Salvolini, Eleonora; Vignini, Arianna; Sabbatinelli, Jacopo; Pompei, Veronica; Sartini, Davide; Cester, Anna Maria; Ciavattini, Andrea; Mazzanti, Laura; Emanuelli, Monica] Univ Politecn Marche, Dept Clin Sci, Via Tronto 10-A, I-60126 Ancona, Italy.
   [Lucarini, Guendalina] Univ Politecn Marche, Dept Clin & Mol Sci, Via Tronto 10-A, Ancona, Italy.
C3 Marche Polytechnic University; Marche Polytechnic University
RP Salvolini, E (corresponding author), Univ Politecn Marche, Dept Clin Sci, Via Tronto 10-A, I-60126 Ancona, Italy.
EM e.salvolini@univpm.it
RI Ciavattini, Andrea/AAW-6212-2020; Lucarini, Guendalina/AAA-7335-2021;
   Sabbatinelli, Jacopo/U-1851-2018
OI Ciavattini, Andrea/0000-0002-8037-4947; Sabbatinelli,
   Jacopo/0000-0001-9947-6778; Pompei, Veronica/0000-0002-3747-9348;
   SARTINI, Davide/0000-0003-3879-8647
FU RSA Grants from Universita Politecnica delle Marche
FX The present work was supported by RSA Grants from Universita Politecnica
   delle Marche.
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NR 45
TC 16
Z9 18
U1 0
U2 5
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0948-6143
EI 1432-119X
J9 HISTOCHEM CELL BIOL
JI Histochem. Cell Biol.
PD DEC
PY 2019
VL 152
IS 6
BP 415
EP 422
DI 10.1007/s00418-019-01819-y
PG 8
WC Cell Biology; Microscopy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Microscopy
GA KJ8JX
UT WOS:000512303100003
PM 31552486
DA 2025-06-11
ER

PT J
AU Zambonelli, P
   Gaffo, E
   Zappaterra, M
   Bortoluzzi, S
   Davoli, R
AF Zambonelli, P.
   Gaffo, E.
   Zappaterra, M.
   Bortoluzzi, S.
   Davoli, R.
TI Transcriptional profiling of subcutaneous adipose tissue in Italian
   Large White pigs divergent for backfat thickness
SO ANIMAL GENETICS
LA English
DT Article
DE differential analysis; fat deposition; gene expression; subcutaneous
   adipose tissue; swine
ID EST DATA EXPLORER; RNA-SEQ; DIFFERENTIAL EXPRESSION; PORCINE
   TRANSCRIPTOME; METABOLIC SYNDROME; NONCODING RNAS; FAT TISSUE; GENES;
   OBESITY; IDENTIFICATION
AB Fat deposition is a widely studied trait in pigs because of its implications with animal growth efficiency, technological and nutritional characteristics of meat products, but the global framework of the biological and molecular processes regulating fat deposition in pigs is still incomplete. This study describes the backfat tissue transcription profile in Italian Large White pigs and reports genes differentially expressed between fat and lean animals according to RNA-seq data. The backfat transcription profile was characterised by the expression of 23483 genes, of which 54.1% were represented by known genes. Of 63418 expressed transcripts, about 80% were non-previously annotated isoforms. By comparing the expression level of fat vs. lean pigs, we detected 86 robust differentially expressed transcripts, 72 more highly expressed (e.g. ACP5, BCL2A1, CCR1, CD163, CD1A, EGR2, ENPP1, GPNMB, INHBB, LYZ, MSR1, OLR1, PIK3AP1, LIN2, SPP1, SLC11A1, STC1) and 14 lower expressed (e.g. ADSSL1, CDO1, DNAJB1, HSPA1A, HSPA1B, HSPA2, HSPB8, IGFBP5, OLFML3) in fat pigs. The main functional categories enriched in differentially expressed genes were immune system process, response to stimulus, cell activation and skeletal system development, for the overexpressed genes, and unfolded protein binding and stress response, for the underexpressed genes, which included five heat shock proteins. Adipose tissue alterations and impaired stress response are linked to inflammation and, in turn, to adipose tissue secretory activity, similar to what is observed in human obesity. Our results provide the opportunity to identify biomarkers of carcass fat traits to improve the pig production chain and to identify genetic factors that regulate the observed differential expression.
C1 [Zambonelli, P.; Zappaterra, M.; Davoli, R.] Univ Bologna, Dept Agr & Food Sci DISTAL, Via Fratelli Rosselli 107, I-42123 Reggio Emilia, Italy.
   [Gaffo, E.; Bortoluzzi, S.] Univ Padua, Dept Mol Med, Via Gabelli 63, I-35121 Padua, Italy.
C3 University of Bologna; University of Padua
RP Davoli, R (corresponding author), Univ Bologna, Dept Agr & Food Sci DISTAL, Via Fratelli Rosselli 107, I-42123 Reggio Emilia, Italy.; Bortoluzzi, S (corresponding author), Univ Padua, Dept Mol Med, Via Gabelli 63, I-35121 Padua, Italy.
EM stefania.bortoluzzi@unipd.it; roberta.davoli@unibo.it
RI zappaterra, martina/AAT-1923-2020; Gaffo, Enrico/HHN-7272-2022;
   Bortoluzzi, Stefania/G-8211-2011; Zambonelli, Paolo/N-3084-2014
OI Bortoluzzi, Stefania/0000-0001-8240-3070; Zappaterra,
   Martina/0000-0001-5085-4811; GAFFO, Enrico/0000-0001-6338-7677;
   Zambonelli, Paolo/0000-0002-2532-5528
FU Progetto 'AGER - Agroalimentare e Ricerca': advanced research in
   genomics and processing technologies for the Italian heavy pig
   production - Hepiget [2011- 0279]
FX We thank Dr. Maurizio Gallo from Associazione Nazionale Allevatori Suini
   (ANAS) and Dr. Luca Buttazzoni (CREA-PCM) for providing the porcine
   backfat tissue samples and BMR Genomics for performing the RNA-seq. This
   work was supported by Progetto 'AGER - Agroalimentare e Ricerca':
   advanced research in genomics and processing technologies for the
   Italian heavy pig production - Hepiget (Grant N. 2011- 0279).
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NR 82
TC 45
Z9 49
U1 1
U2 32
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0268-9146
EI 1365-2052
J9 ANIM GENET
JI Anim. Genet.
PD JUN
PY 2016
VL 47
IS 3
BP 306
EP 323
DI 10.1111/age.12413
PG 18
WC Agriculture, Dairy & Animal Science; Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture; Genetics & Heredity
GA DK5WJ
UT WOS:000374991500004
PM 26931818
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Sivasinprasasn, S
   Sa-nguanmoo, P
   Pratchayasakul, W
   Kumfu, S
   Chattipakorn, SC
   Chattipakorn, N
AF Sivasinprasasn, Sivaporn
   Sa-nguanmoo, Piangkwan
   Pratchayasakul, Wasana
   Kumfu, Sirinart
   Chattipakorn, Siriporn C.
   Chattipakorn, Nipon
TI Obese-insulin resistance accelerates and aggravates cardiometabolic
   disorders and cardiac mitochondrial dysfunction in estrogen-deprived
   female rats
SO AGE
LA English
DT Article
DE Obesity; Insulin resistance; Estrogen deprivation; Mitochondria;
   Cardiometabolic function
ID HEART-RATE-VARIABILITY; OXIDATIVE STRESS; MORTALITY
AB Women have a lower incidence of cardiovascular diseases (CVD) than men at a similar age but have an increased incidence of CVD and metabolic syndrome after menopause, indicating the possible protective effects of estrogen on cardiometabolic function. Although obesity is known to increase CVD risks, its impact on the heart on estrogen deprivation is still inconclusive. We investigated the effects of obese-insulin resistance on cardiometabolic function in estrogen-deprived ovariectomized rats. Adult female ovariectomized (O) or sham (S)-operated rats randomly received either normal diet (ND, 19.77 % fat) or high-fat diet (HF, 57.60 % fat) (n= 6/group) for 12 weeks. The heart rate variability (HRV), left ventricular (LV) performance, cardiac autonomic balance, cardiacmitochondrial function, metabolic parameters, oxidative stress, and apoptotic markers were determined at 4, 8, and 12 weeks. Insulin resistance developed at week 8 in NDO, HFS, and HFO rats as indicated by increased plasma insulin and HOMA index. However, only HFO rats had elevated plasma cholesterol level at week 8, whereas HFS rats had showed elevation at week 12. In addition, only HFO rats had depressedHRV, impaired LVperformance indicated by decreased fractional shortening (%FS) and cardiac mitochondrial dysfunction indicated by increased mitochondrial ROS level, mitochondrial depolarization and swelling, as early as week 8, whereas other groups exhibited them at week 12. Either estrogen deprivation or obesity alone may impair metabolic parameters, cardiac autonomic balance, and LV and mitochondrial function. However, an obese insulin-resistant condition further accelerated and aggravated the development of these cardiometabolic impairments in estrogen-deprived rats.
C1 [Sivasinprasasn, Sivaporn; Sa-nguanmoo, Piangkwan; Pratchayasakul, Wasana; Kumfu, Sirinart; Chattipakorn, Siriporn C.; Chattipakorn, Nipon] Chiang Mai Univ, Cardiac Electrophysiol Res & Training Ctr, Fac Med, Chiang Mai 50200, Thailand.
   [Sivasinprasasn, Sivaporn] Mae Fah Luang Univ, Sch Hlth Sci, Chiang Rai 57100, Thailand.
   [Sivasinprasasn, Sivaporn; Sa-nguanmoo, Piangkwan; Pratchayasakul, Wasana; Kumfu, Sirinart; Chattipakorn, Nipon] Chiang Mai Univ, Dept Physiol, Cardiac Electrophysiol Unit, Fac Med, Chiang Mai 50200, Thailand.
   [Chattipakorn, Siriporn C.] Chiang Mai Univ, Dept Oral Biol & Diagnost Sci, Fac Dent, Chiang Mai 50200, Thailand.
   [Sivasinprasasn, Sivaporn; Sa-nguanmoo, Piangkwan; Pratchayasakul, Wasana; Kumfu, Sirinart; Chattipakorn, Siriporn C.; Chattipakorn, Nipon] Chiang Mai Univ, Ctr Excellence Cardiac Electrophysiol Res, Chiang Mai 50200, Thailand.
C3 Chiang Mai University; Mae Fah Luang University; Chiang Mai University;
   Chiang Mai University; Chiang Mai University
RP Chattipakorn, N (corresponding author), Chiang Mai Univ, Ctr Excellence Cardiac Electrophysiol Res, Chiang Mai 50200, Thailand.
EM nchattip@gmail.com
RI Chattipakorn, Nipon/AAJ-4049-2021
OI Sa-nguanmoo, Piangkwan/0000-0002-4795-8473; pratchayasakul,
   wasana/0000-0003-3970-4323; Chattipakorn, Nipon/0000-0003-3026-718X;
   Chattipakorn, Siriporn/0000-0003-1677-7052
FU NSTDA Research Chair Grant from the National Science and Technology
   Development Agency; Thailand Research Fund [RTA5580006, BRG5780016,
   TRG5680018, TRG5780002]; Faculty of Medicine Endowment Fund; Chiang Mai
   University Center of Excellence Award
FX This work was supported by a NSTDA Research Chair Grant from the
   National Science and Technology Development Agency (NC), the Thailand
   Research Fund RTA5580006 (NC), BRG5780016 (SC), TRG5680018 (WP),
   TRG5780002 (SK), Faculty of Medicine Endowment Fund (WP), and the Chiang
   Mai University Center of Excellence Award (NC).
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NR 25
TC 36
Z9 36
U1 0
U2 2
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0161-9152
EI 1574-4647
J9 AGE
JI Age
PD APR
PY 2015
VL 37
IS 2
AR 28
DI 10.1007/s11357-015-9766-0
PG 11
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA CE5EU
UT WOS:000351854300013
PM 25791519
OA Green Published
DA 2025-06-11
ER

PT J
AU Nanjappa, MK
   Ahuja, M
   Dhanasekaran, M
   Coleman, ES
   Braden, TD
   Bartol, FF
   Bird, RC
   Wanders, D
   Judd, RL
   Akingbemi, BT
AF Nanjappa, Manjunatha K.
   Ahuja, Manuj
   Dhanasekaran, Muralikrishnan
   Coleman, Elaine S.
   Braden, Tim D.
   Bartol, Frank F.
   Bird, R. Curtis
   Wanders, Desiree
   Judd, Robert L.
   Akingbemi, Benson T.
TI Bisphenol A regulation of testicular endocrine function in male rats is
   affected by diet
SO TOXICOLOGY LETTERS
LA English
DT Article
DE Xenoestrogen; Leydig cells; Steroid hormones; Adiponectin; Oxidative
   stress
ID HIGH-FAT DIET; LEYDIG-CELLS; ESTROGEN SULFOTRANSFERASE; OXIDATIVE
   STRESS; PERINATAL EXPOSURE; METABOLIC SYNDROME; GENE-EXPRESSION;
   MAMMARY-GLAND; ADULT RATS; VITAMIN-C
AB There is concern that early-life exposure to bisphenol A (BPA) may alter developmental programming and predispose individuals to obesity and reproductive anomalies. The present study was designed to determine if a high fat diet at sexual maturation moderates testicular toxicity occasioned by exposure to BPA during reproductive development. Therefore, male rats were exposed to BPA by maternal gavage (0, 2.5 or 25 mu g/kg body weight/day) from gestational day 12 to postnatal day 21. At weaning, control and BPA-exposed animals were placed on a regular normal fat diet (NFD) until 70 days of age when they were continued on the NFD or were maintained on a high fat diet (HFD) until euthanasia at 98 days. Adult male rats maintained on HFD were generally heavier than NFD animals due to greater energy intake but energy intake per unit body weight gain was similar in all animals. However, perinatal exposure to BPA decreased (P < 0.05) serum adiponectin as well as adiponectin and AdipoR2 protein expression levels in Leydig cells. Importantly, the combination of BPA exposure and HFD consumption promoted lipid peroxidation evidenced by elevated serum thiobarbituric acid reactive substances and glutathione concentrations. These findings imply that interaction between BPA and HFD potentially causes testicular dysfunction to a greater degree than would be due to BPA exposure or HFD consumption. Given the relationship that exists between energy homeostasis and reproductive activity, additional studies are warranted to investigate the consequences of BPA-diet interactions on testicular function. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
C1 [Nanjappa, Manjunatha K.; Coleman, Elaine S.; Braden, Tim D.; Bartol, Frank F.; Wanders, Desiree; Judd, Robert L.; Akingbemi, Benson T.] Auburn Univ, Dept Anat Physiol & Pharmacol, Auburn, AL 36849 USA.
   [Ahuja, Manuj; Dhanasekaran, Muralikrishnan] Auburn Univ, Sch Pharm, Dept Pharmacal Sci, Auburn, AL 36849 USA.
   [Bird, R. Curtis] Auburn Univ, Dept Pathobiol, Auburn, AL 36849 USA.
C3 Auburn University System; Auburn University; Auburn University System;
   Auburn University; Auburn University System; Auburn University
RP Akingbemi, BT (corresponding author), Auburn Univ, Dept Anat Physiol & Pharmacol, Auburn, AL 36849 USA.
EM akingbt@auburn.edu
RI Ahuja, Manuj/AAL-2356-2020; Nanjappa, Manjunatha/G-8333-2015
OI Wanders, Desiree/0000-0003-2638-3954; Nanjappa,
   Manjunatha/0000-0001-5295-2220
FU College of Veterinary Medicine, Auburn University; National Institutes
   of Health [ES 15886]
FX This study was supported in part by the Animal Health and Disease
   Research and Boshell Diabetes Research Programs at the College of
   Veterinary Medicine, Auburn University and by the National Institutes of
   Health Grant ES 15886 (to BTA). Data were presented in preliminary form
   at the 44th Annual Meeting of the Society for the Study of Reproduction,
   July 31-August 4, 2011, Portland OR, and at the 94th Annual meeting of
   the Endocrine Society, June 15-18, 2012, Houston TX.
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NR 73
TC 8
Z9 12
U1 0
U2 24
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0378-4274
EI 1879-3169
J9 TOXICOL LETT
JI Toxicol. Lett.
PD MAR 21
PY 2014
VL 225
IS 3
BP 479
EP 487
DI 10.1016/j.toxlet.2014.01.024
PG 9
WC Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Toxicology
GA AB3YF
UT WOS:000331725400017
PM 24472609
OA Bronze
DA 2025-06-11
ER

PT J
AU Sinaiko, AR
   Steinberger, J
   Moran, A
   Prineas, RJ
   Vessby, B
   Basu, S
   Tracy, R
   Jacobs, DR
AF Sinaiko, AR
   Steinberger, J
   Moran, A
   Prineas, RJ
   Vessby, B
   Basu, S
   Tracy, R
   Jacobs, DR
TI Relation of body mass index and insulin resistance to cardiovascular
   risk factors, inflammatory factors, and oxidative stress during
   adolescence
SO CIRCULATION
LA English
DT Article
DE insulin; obesity; pediatrics; risk factors
ID C-REACTIVE PROTEIN; NUTRITION EXAMINATION SURVEY; AFRICAN-AMERICAN
   CHILDREN; TYPE-2 DIABETES-MELLITUS; 3RD NATIONAL-HEALTH; METABOLIC
   SYNDROME; FASTING INSULIN; BLOOD-PRESSURE; YOUNG-ADULTS; BETA-CELL
AB Background-This study assessed the relation of fatness and insulin resistance and their interaction with cardiovascular risk factors, inflammatory factors, and oxidative stress in thin and heavy adolescents.
   Methods and Results-Euglycemic insulin clamp studies were performed on 295 (169 male, 126 female) adolescents (mean +/- SE age, 15 +/- 0.1 years). Comparisons were made between (1) heavy and thin adolescents; (2) insulin-sensitive and insulin-resistant adolescents; and (3) thin insulin-sensitive (T-IS), thin insulin-resistant (T-IR), heavy insulin-sensitive (H-IS), and heavy insulin-resistant (H-IR) adolescents. Summed z scores were used to determine clustering of risk factors (fasting insulin, triglycerides, HDL-C, and systolic blood pressure [SBP]) among the groups. SBP, triglycerides, and fasting insulin were significantly higher and HDL-C significantly lower in the heavy adolescents. Fasting insulin and triglycerides were significantly higher and HDL-C significantly lower in the insulin-resistant adolescents. Among the 4 groups, the risk factors and cluster score followed a pattern of risk as follows: T-IS<T-IR<H-IS<H-IR, with H-IR significantly greater than the other groups and showing an interaction between fatness and insulin resistance.
   Conclusions-These results show the significant association of both fatness and insulin resistance and their significant interaction with cardiovascular risk factors in adolescence. The finding that insulin resistance may be acting interactively with fatness suggests that interventions directed at insulin resistance in addition to weight loss may be required to alter early development of cardiovascular risk.
C1 Univ Minnesota, Sch Med, Dept Pediat, Minneapolis, MN 55455 USA.
   Wake Forest Univ, Sch Med, Dept Publ Hlth Sci, Winston Salem, NC 27109 USA.
   Uppsala Univ, Dept Publ Hlth & Caring Sci, Uppsala, Sweden.
   Univ Vermont, Dept Pathol, Burlington, VT 05405 USA.
   Univ Minnesota, Sch Publ Hlth, Div Epidemiol, Minneapolis, MN 55455 USA.
   Univ Oslo, Dept Nutr, Oslo, Norway.
C3 University of Minnesota System; University of Minnesota Twin Cities;
   Wake Forest University; Uppsala University; University of Vermont;
   University of Minnesota System; University of Minnesota Twin Cities;
   University of Oslo
RP Univ Minnesota, Sch Med, Dept Pediat, 420 Delaware St SE,Box 491 UMHC, Minneapolis, MN 55455 USA.
EM Sinai001@tc.umn.edu
RI Jacobs, David/G-5405-2011
OI Jacobs, David/0000-0002-7232-0543; Steinberger,
   Julia/0000-0002-2892-8594
FU NCRR NIH HHS [M01RR00400] Funding Source: Medline; NHLBI NIH HHS
   [HL52851] Funding Source: Medline
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NR 48
TC 185
Z9 220
U1 0
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0009-7322
EI 1524-4539
J9 CIRCULATION
JI Circulation
PD APR 19
PY 2005
VL 111
IS 15
BP 1985
EP 1991
DI 10.1161/01.CIR.0000161837.23846.57
PG 7
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 917KS
UT WOS:000228461000019
PM 15837953
DA 2025-06-11
ER

PT J
AU Kujiraoka, T
   Kagami, K
   Kimura, T
   Ishinoda, Y
   Shiraishi, Y
   Ido, Y
   Endo, S
   Satoh, Y
   Adachi, T
AF Kujiraoka, Takehiko
   Kagami, Kazuki
   Kimura, Toyokazu
   Ishinoda, Yuki
   Shiraishi, Yasunaga
   Ido, Yasuo
   Endo, Shogo
   Satoh, Yasushi
   Adachi, Takeshi
TI Metabolic Remodeling with Hepatosteatosis Induced Vascular Oxidative
   Stress in Hepatic ERK2 Deficiency Mice with High Fat Diets
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE ERK2; metabolic syndrome; metabolism; hepatosteatosis; insulin
   resistance; endothelial dysfunction
ID INSULIN-RESISTANCE; ASYMMETRIC DIMETHYLARGININE; SKELETAL-MUSCLE;
   RECEPTOR; DISEASE; ACID; CONTRIBUTES; ENZYMES; RATIO
AB We previously demonstrated the marked hepatosteatosis and endothelial dysfunction in hepatocyte-specific ERK2 knockout mice (LE2KO) with a high-fat/high-sucrose diet (HFHSD), but detailed metabolic changes and the characteristics in insulin-sensitive organs were not tested. This study aimed to characterize metabolic remodeling with changes in insulin-sensitive organs, which could induce endothelial dysfunction in HFHSD-LE2KO. The serum glucose and fatty acid (FA) were modestly higher in HFHSD-LE2KO than HFHSD-Control. FA synthesis genes were up-regulated, which was associated with the decreased phosphorylation of AMPK and ACC, and with the up-regulation of SREBP-1 in the liver from HFHSD-LE2KO. In FA and amino acids fraction analysis, arachidonic acid/eicosapentaenoic acid ratio, L-ornithine/arginine ratio, asymmetric dimethylarginine and homocysteine levels were elevated in HFHSD-LE2KO. Insulin-induced phosphorylation of AKT was blunted in skeletal muscle. Serum leptin and IL-1 beta were elevated, and serum adiponectin was decreased with the enlargement of epididymal adipocytes. Finally, the enhanced superoxide levels in the aorta, which were blunted with CCCP, apocynin, and tempol, were observed in HFHSD-LE2KO. A pre-incubation of aortic rings with tempol improved endothelial dysfunction in HFHSD-LE2KO. HFHSD-LE2KO revealed an acceleration of FA synthesis in the liver leading to insulin resistance in skeletal muscle and the enlargement of visceral adipocytes. Global metabolic remodeling such as changes in arginine metabolism, omega 3/omega 6 ratio, and adipocytokines, could affect the vascular oxidative stress and endothelial dysfunction in HFHSD-LE2KO.
C1 [Kujiraoka, Takehiko; Kagami, Kazuki; Kimura, Toyokazu; Ishinoda, Yuki; Shiraishi, Yasunaga; Ido, Yasuo; Adachi, Takeshi] Natl Def Med Coll, Div Cardiovasc Med, 3-2 Namiki, Tokorozawa, Saitama 3598513, Japan.
   [Endo, Shogo] Tokyo Metropolitan Geriatr Hosp & Inst Gerontol, Aging Regulat Res Team, 35-2 Sakaecho, Tokyo 1730015, Japan.
   [Satoh, Yasushi] Natl Def Med Coll, Dept Anesthesiol, 3-2 Namiki, Tokorozawa, Saitama 3598513, Japan.
C3 National Defense Medical College - Japan; Tokyo Metropolitan Institute
   of Gerontology; National Defense Medical College - Japan
RP Adachi, T (corresponding author), Natl Def Med Coll, Div Cardiovasc Med, 3-2 Namiki, Tokorozawa, Saitama 3598513, Japan.
EM kujiraniku5221@hotmail.co.jp; mirror.1028k@gmail.com;
   oyotikuuyakim@gmail.com; isshiishigoto@yahoo.co.jp;
   sirayasu10@hotmail.co.jp; yido@bu.edu; sendo@tmig.or.jp; ys@ndmc.ac.jp;
   kenada@ndmc.ac.jp
RI ; Endo, Shogo/LKJ-5968-2024
OI Kimura, Toyokazu/0000-0002-1347-5115; Shiraishi,
   Yasunaga/0000-0001-5901-4026; Endo, Shogo/0000-0002-3948-8723; Satoh,
   Yasushi/0000-0002-0527-6319
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NR 37
TC 4
Z9 5
U1 0
U2 3
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD AUG
PY 2022
VL 23
IS 15
AR 8521
DI 10.3390/ijms23158521
PG 14
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 3S0JC
UT WOS:000839288700001
PM 35955653
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Elrakaybi, A
   Laubner, K
   Zhou, Q
   Hug, MJ
   Seufert, J
AF Elrakaybi, Asmaa
   Laubner, Katharina
   Zhou, Qian
   Hug, Martin J.
   Seufert, Jochen
TI Cardiovascular protection by SGLT2 inhibitors-Do anti-inflammatory
   mechanisms play a role?
SO MOLECULAR METABOLISM
LA English
DT Review
DE SGLT2 inhibitors; In flammation; Metabolism; Heart failure;
   Cardiovascular disease
ID EPICARDIAL ADIPOSE-TISSUE; RENIN-ANGIOTENSIN SYSTEM; NLRP3 INFLAMMASOME
   ACTIVATION; CONVERTING ENZYME-INHIBITION; LEFT-VENTRICULAR HYPERTROPHY;
   COTRANSPORTER 2 INHIBITION; CONGESTIVE-HEART-FAILURE; TYPE-2
   DIABETES-MELLITUS; SERUM URIC-ACID; OXIDATIVE STRESS
AB Background: Metabolic syndrome and related metabolic disturbances represent a state of low-grade inflammation, which accelerates insulin resistance, type 2 diabetes (T2D) and cardiovascular disease (CVD) progression. Among antidiabetic medications, sodium glucose co-transporter (SGLT) 2 inhibitors are the only agents which showed remarkable reductions in heart failure (HF) hospitalizations and major cardiovascular endpoints (MACE) as well as renal endpoints regardless of diabetes status in large randomized clinical outcome trials (RCTs). Although the exact mechanisms underlying these benefits are yet to be established, growing evidence suggests that modulating inflammation by SGLT2 inhibitors may play a key role.Scope of review: In this manuscript, we summarize the current knowledge on anti-inflammatory effects of SGLT2 inhibitors as one of the mechanisms potentially mediating their cardiovascular (CV) benefits. We introduce the different metabolic and systemic actions mediated by these agents which could mitigate inflammation, and further present the signalling pathways potentially responsible for their proposed direct antiinflammatory effects. We also discuss controversies surrounding some of these mechanisms.Major conclusions: SGLT2 inhibitors are promising anti-inflammatory agents by acting either indirectly via improving metabolism and reducing stress conditions or via direct modulation of inflammatory signalling pathways. These effects were achieved, to a great extent, in a glucoseindependent manner which established their clinical use in HF patients with and without diabetes. (c) 2022 The Author(s). Published by Elsevier GmbH. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
C1 [Elrakaybi, Asmaa; Laubner, Katharina; Seufert, Jochen] Univ Freiburg, Med Ctr, Fac Med, Div Endocrinol & Diabetol,Dept Med 2, D-79106 Freiburg, Germany.
   [Elrakaybi, Asmaa] Ain Shams Univ, Dept Clin Pharm, Cairo 11566, Egypt.
   [Zhou, Qian] Univ Freiburg, Fac Med, Heart Ctr, Dept Cardiol & Angiol 1, D-79106 Freiburg, Germany.
   [Zhou, Qian] Univ Hosp Basel, Dept Cardiol, CH-4031 Basel, Switzerland.
   [Hug, Martin J.] Univ Freiburg, Med Ctr, Pharm, D-79106 Freiburg, Germany.
   [Seufert, Jochen] Univ Freiburg, Med Ctr, Dept Med 2, Div Endocrinol & Diabetol, Hugstetter Str 55, D-79106 Freiburg, Germany.
C3 University of Freiburg; Egyptian Knowledge Bank (EKB); Ain Shams
   University; Universitats Herzzentrum Freiburg; University of Freiburg;
   University of Basel; University of Freiburg; University of Freiburg
RP Seufert, J (corresponding author), Univ Freiburg, Med Ctr, Dept Med 2, Div Endocrinol & Diabetol, Hugstetter Str 55, D-79106 Freiburg, Germany.
EM jochen.seufert@uniklinik-freiburg.de
RI Zhou, Qian/ABC-7574-2021
OI Seufert, Jochen/0000-0001-5654-7310; Zhou, Qian/0000-0002-1828-4879
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NR 304
TC 50
Z9 50
U1 0
U2 9
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2212-8778
J9 MOL METAB
JI Mol. Metab.
PD OCT
PY 2022
VL 64
AR 101549
DI 10.1016/j.molmet.2022.101549
EA JUL 2022
PG 22
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 3Z0EN
UT WOS:000844094200007
PM 35863639
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Kawarazaki, W
   Fujita, T
AF Kawarazaki, Wakako
   Fujita, Toshiro
TI Kidney and epigenetic mechanisms of salt-sensitive hypertension
SO NATURE REVIEWS NEPHROLOGY
LA English
DT Review
ID MINERALOCORTICOID RECEPTOR ACTIVATION; OBESITY-INDUCED HYPERTENSION;
   ARTERIAL-PRESSURE ELEVATION; BLOOD-PRESSURE; ANGIOTENSIN-II; METABOLIC
   SYNDROME; KLOTHO GENE; PARAVENTRICULAR NUCLEUS; RENAL DENERVATION;
   OXIDATIVE STRESS
AB In this Review, the authors discuss the renal mechanism of salt-sensitive hypertension induced by malnutrition during pregnancy, obesity in adult life and ageing. They also describe the epigenetic mechanisms that potentially contribute to the development of salt-sensitive hypertension in these settings.
   Dietary salt intake increases blood pressure (BP) but the salt sensitivity of BP differs between individuals. The interplay of ageing, genetics and environmental factors, including malnutrition and stress, contributes to BP salt sensitivity. In adults, obesity is often associated with salt-sensitive hypertension. The children of women who experience malnutrition during pregnancy are at increased risk of developing obesity, diabetes and salt-sensitive hypertension as adults. Similarly, the offspring of mice that are fed a low-protein diet during pregnancy develop salt-sensitive hypertension in association with aberrant DNA methylation of the gene encoding type 1A angiotensin II receptor (AT(1A)R) in the hypothalamus, leading to upregulation of hypothalamic AT(1A)R and renal sympathetic overactivity. Ageing is also associated with salt-sensitive hypertension. In aged mice, promoter methylation leads to reduced kidney production of the anti-ageing factor Klotho and a decrease in circulating soluble Klotho. In the setting of Klotho deficiency, salt-induced activation of the vascular Wnt5a-RhoA pathway leads to ageing-associated salt-sensitive hypertension, potentially as a result of reduced renal blood flow and increased peripheral resistance. Thus, kidney mechanisms and aberrant DNA methylation of certain genes are involved in the development of salt-sensitive hypertension during fetal development and old age. Three distinct paradigms of epigenetic memory operate on different timescales in prenatal malnutrition, obesity and ageing.
C1 [Kawarazaki, Wakako; Fujita, Toshiro] Univ Tokyo, Res Ctr Adv Sci & Technol, Div Clin Epigenet, Tokyo, Japan.
   [Fujita, Toshiro] Shinshu Univ, Sch Med, Matsumoto, Nagano, Japan.
   [Fujita, Toshiro] Shinshu Univ, Res Ctr Social Syst, Matsumoto, Nagano, Japan.
C3 University of Tokyo; Shinshu University; Shinshu University
RP Fujita, T (corresponding author), Univ Tokyo, Res Ctr Adv Sci & Technol, Div Clin Epigenet, Tokyo, Japan.; Fujita, T (corresponding author), Shinshu Univ, Sch Med, Matsumoto, Nagano, Japan.; Fujita, T (corresponding author), Shinshu Univ, Res Ctr Social Syst, Matsumoto, Nagano, Japan.
EM Toshiro.FUJITA@rcast.u-tokyo.ac.jp
RI Kawarazaki, Wakako/GPP-2721-2022; Kawarazaki, Wakako/LIG-5150-2024
OI Fujita, Toshiro/0000-0001-9141-7060; Kawarazaki,
   Wakako/0000-0002-1332-8537
FU JSPS KAKENHI [15H05788, 18K08028, 20K21596]; EA Pharma; MSD K.K.; Asahi
   Group Holdings; Astellas Pharma; Omron Healthcare; Shionogi; Mochida
   Pharmaceutical; Chugai Pharmaceutical; Mitsubishi Tanabe Pharma; Toray
   Industries; Nippon Boehringer Ingelheim; Fukuda Denshi; Kyowa Kirin;
   Novartis Pharma; Pfizer; Takeda Pharmaceutical; Grants-in-Aid for
   Scientific Research [18K08028, 15H05788, 20K21596] Funding Source: KAKEN
FX This review article is based on T. F.'s 2019 ASN Homer W. Smith Award
   lecture, ASN Kidney Week, Washington DC, USA. T.F. acknowledges the
   excellent support and contributions of K. Ando, T. Shimosawa, M. Nagase,
   M. Isshiki, T. Marumo, S. Oba, R. Mizuno, Y. Shibagaki, M. Fujita, F.
   Kawakami-Mori, S. Shibata, H. Kawarazaki, S. Mu, W. Kawarazaki, M.
   Nishimoto, N. Ayuzawa, D. Hirohama and K. Ueda to his research into
   salt-sensitive hypertension. The authors' research was supported by JSPS
   KAKENHI (Grant nos 15H05788, 18K08028 and 20K21596). The authors are
   members of the Division of Clinical Epigenetics, University of Tokyo,
   which is supported by an unrestricted grant from EA Pharma, MSD K.K.,
   Asahi Group Holdings, Astellas Pharma, Omron Healthcare, Shionogi,
   Mochida Pharmaceutical, Chugai Pharmaceutical, Mitsubishi Tanabe Pharma,
   Toray Industries, Nippon Boehringer Ingelheim, Fukuda Denshi, Kyowa
   Kirin, Novartis Pharma, Pfizer and Takeda Pharmaceutical.
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NR 221
TC 54
Z9 56
U1 1
U2 28
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 1759-5061
EI 1759-507X
J9 NAT REV NEPHROL
JI Nat. Rev. Nephrol.
PD MAY
PY 2021
VL 17
IS 5
BP 350
EP 363
DI 10.1038/s41581-021-00399-2
EA FEB 2021
PG 14
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA RQ5MM
UT WOS:000621322800001
PM 33627838
DA 2025-06-11
ER

PT J
AU Liu, XH
   Zeng, X
   Liu, W
   Lu, YR
   Cheng, JQ
   Chen, YN
AF Liu, Xiaohong
   Zeng, Xin
   Liu, Wen
   Lu, Yanrong
   Cheng, Jingqiu
   Chen, Younan
TI An Overview of Dietary Supplements on Obesity and Type 2 Diabetes:
   Efficacy and Mechanisms
SO CURRENT DRUG METABOLISM
LA English
DT Review
DE Obesity; type 2 diabetes; dietary supplements; plant bioactive
   ingredients; natural products; beta cell function
ID CONJUGATED LINOLEIC-ACID; CHAIN FATTY-ACIDS; AMELIORATES
   INSULIN-RESISTANCE; HUMAN CYTOCHROME-P450 ENZYMES; ENDOPLASMIC-RETICULUM
   STRESS; OXIDATIVE STRESS; METABOLIC SYNDROME; DOUBLE-BLIND; WEIGHT-LOSS;
   GREEN TEA
AB Obesity is a common nutritional disorder associated with a variety of chronic diseases, among them, type 2 diabetes (T2DM) has emerged as a serious worldwide health problem. Insulin resistance and beta cell dysfunction are the main pathological characteristics of T2DM, and obesity and hyperlipidemia are the critical causal factors. It is commonly accepted that dietary factors are of paramount importance in the management of obesity and T2DM. Particularly, many botanic products and their extracts are endowed with a wide spectrum of biological activities, making them extensively reviewed as anti-obesity and anti-diabetes dietary supplements or new drug candidates. In this review, we aimed to summarize the effects, related mechanisms, and safety issues of dietary continents on obesity and T2DM, to provide theoretical support for better research and development of dietary therapy strategy for the treatment of obesity and T2DM. Based on many clinical investigations, specific carbohydrates and fatty acids, such as dietary fibers, polysaccharides, unsaturated fatty acids, have hypoglycemic and hypolipidemic effects. Vitamin D plays an important role in metabolism and immunity modulation. Apart from them, natural bioactive ingredients from plants, such as flavonoids, polyphenols, alkaloids, terpenoids, polysaccharides, and quinones are efficient in helping weight loss and improving insulin sensitivity and glycemic control. They can protect beta cell function by antiinflammation, anti-oxidation, and anti-apoptosis properties, as well as regulating lipid metabolism. Therefore, promoting the consumption of diverse natural bioactive ingredients-rich products could be an effective nutritional strategy to benefit patients with obesity and type 2 diabetes.
C1 [Liu, Xiaohong; Zeng, Xin; Liu, Wen; Lu, Yanrong; Cheng, Jingqiu; Chen, Younan] Sichuan Univ, Regenerat Med Res Ctr, Key Lab Transplant Engn & Immunol, NHFPC,West China Hosp, Chengdu, Peoples R China.
   [Cheng, Jingqiu; Chen, Younan] Sichuan Univ, West China Hosp, Frontiers Sci Ctr Dis Related Mol Network, Inst Syst Genet, Chengdu, Peoples R China.
C3 Sichuan University; Sichuan University
RP Chen, YN (corresponding author), Frontiers Sci Ctr Dis Related Mol Network, 2222 Xinchuan Rd, Chengdu 610000, Sichuan, Peoples R China.
EM chenyounan@scu.edu.cn
RI Wang, Xiaojun/JUU-9683-2023; Chen, Younan/AAK-1654-2021; Zeng,
   Xin/LZI-5139-2025
OI Zeng, Xin/0000-0002-7856-6923
FU Program of National Natural Science Foundation of China (Chengdu, China)
   [81870609, 81571808]; 1.3.5 project for disciplines of excellence, West
   China Hospital, Sichuan University (Chengdu, China) [ZYGD18014]
FX This study was supported by the Program of National Natural Science
   Foundation of China, (Chengdu, China, 81870609, and 81571808) , and the
   1.3.5 project for disciplines of excellence, West China Hospital,
   Sichuan University (Chengdu, China, ZYGD18014) .
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NR 227
TC 13
Z9 13
U1 3
U2 68
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1389-2002
EI 1875-5453
J9 CURR DRUG METAB
JI Curr. Drug Metab.
PY 2021
VL 22
IS 6
BP 415
EP 440
DI 10.2174/1389200222666210406110450
PG 26
WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
GA TN6SZ
UT WOS:000676363600003
PM 33823775
DA 2025-06-11
ER

EF﻿FN Clarivate Analytics Web of Science
VR 1.0
PT J
AU Mohamad, NE
   Yeap, SK
   Ky, H
   Liew, NWC
   Beh, BK
   Boo, SY
   Ho, WY
   Sharifuddin, SA
   Long, K
   Alitheen, NB
AF Mohamad, Nurul Elyani
   Yeap, Swee Keong
   Ky, Huynh
   Liew, Nancy Woan Charn
   Beh, Boon Kee
   Boo, Sook Yee
   Ho, Wan Yong
   Sharifuddin, Shaiful Adzni
   Long, Kamariah
   Alitheen, Noorjahan Banu
TI Pineapple Vinegar Regulates Obesity-Related Genes and Alters the Gut
   Microbiota in High-Fat Diet (HFD) C57BL/6 Obese Mice
SO EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Article
ID OXIDATIVE STRESS; ADIPOSE-TISSUE; CARDIOVASCULAR-DISEASE; INSULIN
   ACTION; INFLAMMATION; ANTIOXIDANT; ANTIOBESITY; INHIBITION; MARKERS;
   PATHWAY
AB Obesity is a pandemic metabolic syndrome with increasing incidences every year. Among the significant factors that lead to obesity, overconsumption of high-fat food in daily intake is always the main contributor. Functional foods have shown a positive effect on disease prevention and provide health benefits, including counteracting obesity problem. Vinegar is one of the fermented functional beverages that have been consumed for many years, and different types of vinegar showed different bioactivities and efficacies. In this study, we investigated the potential effects of pineapple vinegar as an antiobesity agent on a high-fat diet- (HFD-) induced C57BL/6 obese mice. C57BL/6 mice were treated with pineapple vinegar (1 mL/kg BW and 0.08 mL/kg BW) for 12 weeks after 24 weeks of HFD incubation. Serum biochemistry profiles, antioxidant assays, qPCR, proteome profiler, and 16S metagenomic were done posttreatment. Our data showed that a high concentration of pineapple vinegar (1 mL/kg BW) treatment significantly ( p < 0.05) reduced the bodyweight (similar to 20%), restored lipid profiles, increased the antioxidant activities, and reduced the oxidative stress. Besides, significant (p < 0.05) regulation of several adipokines and inflammatory-related genes was recorded. Through the regulation of gut microbiota, we found a higher abundance ofAkkermansia muciniphila, a microbiota reported to be associated with obesity in the high concentration of pineapple vinegar treatment. Collectively, these data established the mechanism of pineapple vinegar as antiobesity in mice and revealed the potential of pineapple vinegar as a functional food for obesity.
C1 [Mohamad, Nurul Elyani; Beh, Boon Kee; Alitheen, Noorjahan Banu] Univ Putra Malaysia, Fac Biotechnol & Biomol Sci, Dept Cell & Mol Biol, Serdang 43400, Selangor, Malaysia.
   [Yeap, Swee Keong] Xiamen Univ Malaysia, China ASEAN Coll Marine Sci, Sepang 43900, Selangor, Malaysia.
   [Ky, Huynh] Can Tho Univ, Coll Agr, Can Tho, Vietnam.
   [Liew, Nancy Woan Charn] Univ Putra Malaysia, Inst Biosci, Serdang 43400, Selangor, Malaysia.
   [Boo, Sook Yee] Sci Vis Sdn Bhd, Shah Alam 40170, Selangor, Malaysia.
   [Ho, Wan Yong] Univ Nottingham Malaysia, Fac Sci & Engn, Semenyih 43500, Selangor, Malaysia.
   [Sharifuddin, Shaiful Adzni; Long, Kamariah] Malaysian Agr Res & Dev Inst MARDI, Biotechnol Res Ctr, Serdang 43400, Selangor, Malaysia.
C3 Universiti Putra Malaysia; Xiamen University Malaysia Campus; Can Tho
   University; Universiti Putra Malaysia; University of Nottingham Malaysia
RP Alitheen, NB (corresponding author), Univ Putra Malaysia, Fac Biotechnol & Biomol Sci, Dept Cell & Mol Biol, Serdang 43400, Selangor, Malaysia.; Long, K (corresponding author), Malaysian Agr Res & Dev Inst MARDI, Biotechnol Res Ctr, Serdang 43400, Selangor, Malaysia.
EM amai@mardi.gov.my; noorjahan@upm.edu.my
RI Ky, Huynh/AAQ-1926-2021; Alitheen, Noorjahan/AAL-3713-2020; Mohamad,
   Nurul/AAK-5307-2020; Ho, Wan Yong/I-1050-2016; Yeap, Swee
   Keong/H-9285-2013
OI Alitheen, Noorjahan Banu/0000-0003-1966-8580; Ho, Wan
   Yong/0000-0001-5768-0738; Yeap, Swee Keong/0000-0002-4736-0674; Mohamad,
   Nurul Elyani/0000-0003-3461-8602; Ky, Huynh/0000-0002-7615-2866
FU Pembangunan RMK10, MARDI [P2100300125]
FX The authors would also like to thank Professor Dr. Tan Soon Guan and
   Muhammad Firdaus Romli for proofreading the manuscript. This research
   was funded by the grant from Pembangunan RMK10 (project no.
   P2100300125), MARDI.
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NR 94
TC 9
Z9 9
U1 0
U2 9
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1741-427X
EI 1741-4288
J9 EVID-BASED COMPL ALT
JI Evid.-based Complement Altern. Med.
PD SEP 23
PY 2020
VL 2020
AR 1257962
DI 10.1155/2020/1257962
PG 13
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA OB2FU
UT WOS:000578289900007
PM 33029159
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Oviedo-Solís, CI
   Sandoval-Salazar, C
   Lozoya-Gloria, E
   Maldonado-Aguilera, GA
   Aguilar-Zavala, H
   Beltrán-Campos, V
   Pérez-Vázquez, V
   Ramírez-Emiliano, J
AF Oviedo-Solis, Cecilia I.
   Sandoval-Salazar, Cuauhtemoc
   Lozoya-Gloria, Edmundo
   Maldonado-Aguilera, Genaro A.
   Aguilar-Zavala, Herlinda
   Beltran-Campos, Vicente
   Perez-Vazquez, Victoriano
   Ramirez-Emiliano, Joel
TI Ultraviolet light-C increases antioxidant capacity of the strawberry
   (Fragaria x ananassa) in vitro and in high-fat diet-induced obese
   rats
SO FOOD SCIENCE & NUTRITION
LA English
DT Article
DE high-fat diet-induced obese rats; obesity; strawberry antioxidant
   capacity; ultraviolet light-C
ID OXIDATIVE STRESS; METABOLIC SYNDROME; HIGH-CARBOHYDRATE; FRUIT;
   ANTHOCYANINS; EXPRESSION; BLUEBERRY; DAMAGE; SEED; POLYPHENOLS
AB Flavonoids and polyphenols from the strawberry and other fruits have been proposed to reduce the oxidative stress produced by the obesity and her complications. Moreover, it has been proposed that irradiation with UV-C to strawberry may increase the antioxidant capacity of this fruit. The aim of the present study was to explore the effects of the UV-C on antioxidant capacity of strawberry in vitro and in vivo. Strawberry slices were irradiated with ultraviolet light-C (UV-C) at 1.2 W/m(2)/16.5 min; then, the power antioxidant was isolated from the nonirradiated and irradiated strawberry slices into an organic phase, which was lyophilized to finally producing a nonirradiated strawberry extract (NSE) and UV-irradiated strawberry extract (UViSE) powder. After the antioxidant capacity of both extracts were determined in vitro using the Trolox equivalent antioxidant capacity (TEAC) assay and in vivo using high-fat diet-induced obese rats. Our results demonstrated that irradiation with UV-C to strawberry slices increased the antioxidants content, which was corroborated in vitro, where the antioxidant capacity of UViSE was higher than the NSE. However, in obese rats, the reduction in the oxidative damage by the UViSE and NSE were similar in peripheral tissues. Interestingly, the UViSE was better than the NSE to reduce the oxidative damage in brain. In conclusion, UV-irradiation increases the antioxidants content of strawberry that is correlated with an increased antioxidant capacity in vitro, but in rats, this antioxidant capacity may be more effective in brain than in peripheral tissues.
C1 [Oviedo-Solis, Cecilia I.] Univ Guanajuato, Dept Med Nutr, Leon, Gto, Mexico.
   [Sandoval-Salazar, Cuauhtemoc; Maldonado-Aguilera, Genaro A.] Univ Guanajuato, Div Ciencias Salud & Ingn, Dept Enfermeria & Obstet, Celaya, Gto, Mexico.
   [Lozoya-Gloria, Edmundo] CINVESTAV, Lab Bioquim & Biol Mol Prod Nat Plantas, Irapuato, Gto, Mexico.
   [Aguilar-Zavala, Herlinda; Beltran-Campos, Vicente] Univ Guanajuato, Div Ciencias Salud & Ingn, Dept Enfermeria Clin, Celaya, Gto, Mexico.
   [Perez-Vazquez, Victoriano; Ramirez-Emiliano, Joel] Univ Guanajuato, Div Ciencias Salud, Dept Ciencias Med, Campus Leon, Leon, Gto, Mexico.
C3 Universidad de Guanajuato; Universidad de Guanajuato; CINVESTAV - Centro
   de Investigacion y de Estudios Avanzados del Instituto Politecnico
   Nacional; Universidad de Guanajuato; Universidad de Guanajuato
RP Ramírez-Emiliano, J (corresponding author), Univ Guanajuato, Div Ciencias Salud, Dept Ciencias Med, Campus Leon, Leon, Gto, Mexico.
EM joelre@ugto.mx
RI Campos, Vicente/AAD-4793-2019; Oviedo Solís, Cecilia
   Isabel/HGC-5746-2022; Lozoya-Gloria, Edmundo/B-4839-2013; Beltran
   Campos, Vicente/H-8987-2017; Ramirez-Emiliano, Joel/A-9022-2019;
   Perez-Vazquez, Victoriano/B-5030-2010
OI Lozoya-Gloria, Edmundo/0000-0001-7096-0355; Sandoval Salazar,
   Cuauhtemoc/0000-0001-9918-4054; Beltran Campos,
   Vicente/0000-0001-8925-811X; Aguilar Zavala,
   Herlinda/0000-0003-1032-8192; Oviedo-Solis, Cecilia
   Isabel/0000-0002-7666-7341; Ramirez-Emiliano, Joel/0000-0001-9813-9120;
   Perez-Vazquez, Victoriano/0000-0001-9241-9084
FU University of Guanajuato [528/2015]
FX Funding for this study was provided by the University of Guanajuato
   (528/2015) to Beltran-Campos Vicente and Ramirez-Emiliano Joel
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NR 45
TC 9
Z9 9
U1 2
U2 12
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2048-7177
J9 FOOD SCI NUTR
JI Food Sci. Nutr.
PD SEP
PY 2017
VL 5
IS 5
BP 1004
EP 1014
DI 10.1002/fsn3.487
PG 11
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA FL1MP
UT WOS:000413979400006
PM 28948018
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Dong, ML
   Zheng, QJ
   Ford, SP
   Nathanielsz, PW
   Ren, J
AF Dong, Maolong
   Zheng, Qijun
   Ford, Stephen P.
   Nathanielsz, Peter W.
   Ren, Jun
TI Maternal obesity, lipotoxicity and cardiovascular diseases in offspring
SO JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
LA English
DT Review
DE Maternal obesity; Cardiovascular diseases; Obesity; Insulin resistance
ID INSULIN-RESISTANCE; METABOLIC SYNDROME; HEART-FAILURE; FATTY-ACIDS;
   PREGNANCY OUTCOMES; DIABETES-MELLITUS; GLUCOSE-TOLERANCE;
   LIPID-METABOLISM; CARDIAC-FUNCTION; FETAL
AB Maternal obesity has risen dramatically over the past 20 years, by nearly 42% in African-Americans and 29% in Caucasians. Maternal obesity is afflicted with many maternal obstetric complications in the offspring including high blood pressure, obesity, gestational diabetes and increased perinatal morbidity. Maternal nutritional environment plays a rather important role in the programming of the health set-points in the offspring such as glucose and insulin metabolism, energy balance and predisposition to metabolic disorders. In particular, maternal obesity is associated with elevated prevalence of cardiovascular diseases in the offspring. Evidence from human and experimental studies including rodents and nonhuman primates has indicated that maternal obesity or overnutrition programs offspring for an increased risk of adult obesity. Maternal obesity or fat diet exposure predisposes the onset and development of obesity, insulin resistance, cardiac hypertrophy and myocardial contractile anomalies in the offspring. A number of mechanisms including elevated hormones (leptin, insulin), nutrients (fatty acids, triglycerides and glucose) and inflammatory cytokines have been postulated to play a key role in maternal obesity-induced postnatal cardiovascular sequelae. In addition, lipotoxicity (accumulation of lipid metabolites) resulting from maternal obesity is capable of activating a number of stress signaling cascades including pro-inflammatory cytokines and oxidative stress to exacerbate maternal obesity-induced cardiovascular complications later on in adult life. This mini-review summarizes the recent knowledge with regard to the role of lipotoxicity in maternal obesity-induced change in cardiovascular function in the offspring. This article is part of a Special Issue entitled "Focus on Cardiac Metabolism". (C) 2012 Elsevier Ltd. All rights reserved.
C1 [Dong, Maolong; Ren, Jun] Fourth Mil Med Univ, Dept Burn & Cutaneous Surg, Xijing Hosp, Xian 710032, Peoples R China.
   [Dong, Maolong; Ren, Jun] Univ Wyoming, Ctr Cardiovasc Res & Alternat Med, Laramie, WY 82071 USA.
   [Zheng, Qijun] Fourth Mil Med Univ, Xijing Hosp, Dept Cardiovasc Surg, Xian 710032, Peoples R China.
   [Ford, Stephen P.; Ren, Jun] Univ Wyoming, Ctr Study Fetal Programming, Laramie, WY 82071 USA.
   [Nathanielsz, Peter W.] Univ Texas Hlth Sci Ctr San Antonio, Ctr Pregnancy & Newborn Res, San Antonio, TX 78299 USA.
C3 Air Force Medical University; University of Wyoming; Air Force Medical
   University; University of Wyoming; University of Texas System;
   University of Texas Health Science Center at San Antonio
RP Ren, J (corresponding author), Univ Wyoming, Ctr Cardiovasc Res & Alternat Med, Coll Hlth Sci, Laramie, WY 82071 USA.
EM jren@uwyo.edu
RI Ren, Jun/ACG-5366-2022
OI Ren, Jun/0000-0002-0275-0783; Nathanielsz, Peter/0000-0001-8410-6280
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NR 68
TC 96
Z9 107
U1 3
U2 71
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0022-2828
EI 1095-8584
J9 J MOL CELL CARDIOL
JI J. Mol. Cell. Cardiol.
PD FEB
PY 2013
VL 55
BP 111
EP 116
DI 10.1016/j.yjmcc.2012.08.023
PG 6
WC Cardiac & Cardiovascular Systems; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Cell Biology
GA 085PH
UT WOS:000314626200015
PM 22982026
DA 2025-06-11
ER

PT J
AU Li, D
   Luo, N
   Ma, Q
   Li, SZ
   Shi, Q
   Cao, Y
   Zhou, SS
AF Li, Da
   Luo, Ning
   Ma, Qiang
   Li, Shu-Zhuang
   Shi, Qiang
   Cao, Yu
   Zhou, Shi-Sheng
TI Excessive nicotinic acid increases methyl consumption and hydrogen
   peroxide generation in rats
SO PHARMACEUTICAL BIOLOGY
LA English
DT Article
DE Nicotinamide; insulin resistance; oxidative stress; methyl depletion
ID INDUCED INSULIN-RESISTANCE; METABOLIC SYNDROME; OBESITY; NIACIN;
   PREVALENCE; OVERLOAD; RISK
AB Context: Recent ecological evidence has showed a lag-correlation between the prevalence of diabetes and consumption of niacin (nicotinamide and nicotinic acid) in the US. Nicotinamide has been demonstrated to induce insulin resistance due to excess reactive oxygen species and methyl depletion, whereas the effect of nicotinic acid is poorly understood.
   Objective: To examine the mechanism of the effect of nicotinic acid on glucose metabolism.
   Materials and methods: Rats were injected with different cumulative doses of nicotinic acid (0.5, 2, 4 g/kg) and nicotinamide (2 g/kg). A glucose tolerance test was given 2 h after the final injection. The role of methyl consumption and reactive oxygen species generation were evaluated by measuring N-1-methylnicotinamide and hydrogen peroxide.
   Results: Cumulative doses of nicotinic acid produced a dose-dependent increase in the plasma levels of N-1-methylnicotinamide and hydrogen peroxide, which was associated with a decrease in liver and skeletal muscle glycogen levels. At the same dosage (2 g/kg), in comparison with nicotinamide, nicotinic acid was weaker in raising plasma N-1-methylnicotinamide levels (0.7 +/- 0.11 mu g/mL vs. 4.69 +/- 0.24 mu g/mL, P < 0.001), but stronger in increasing plasma hydrogen peroxide levels (1.88 +/- 0.07 mu mol/L vs. 1.55 +/- 0.05 mu mol/L, P < 0.001). Moreover, nicotinamide, unlike nicotinic acid, did not reduce liver glycogen levels.
   Discussion and conclusion: This study suggested that excessive nicotinic acid, like nicotinamide, might induce methyl consumption, oxidative stress and insulin resistance. Long-term consumption high niacin may increase the risk of type 2 diabetes.
C1 [Li, Da; Cao, Yu] China Med Univ, Inst Basic Med Sci, Dept Physiol, Shenyang 110001, Peoples R China.
   [Luo, Ning; Ma, Qiang; Shi, Qiang; Zhou, Shi-Sheng] Dalian Univ, Coll Med, Inst Basic Med Sci, Dalian, Peoples R China.
   [Li, Shu-Zhuang] Dalian Med Univ, Dept Physiol, Dalian, Peoples R China.
C3 China Medical University; Dalian University; Dalian Medical University
RP Cao, Y (corresponding author), China Med Univ, Inst Basic Med Sci, Dept Physiol, Shenyang 110001, Peoples R China.
EM leeda@ymail.com
OI Zhou, Shi-Sheng/0000-0001-5156-3610
FU National Natural Science Foundations of China [31140036, 81000575,
   30971065]
FX This study was supported by National Natural Science Foundations of
   China (No. 31140036, 81000575, 30971065).
CR Abdul-Ghani MA, 2010, J BIOMED BIOTECHNOL, DOI 10.1155/2010/476279
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NR 19
TC 11
Z9 12
U1 0
U2 18
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1388-0209
EI 1744-5116
J9 PHARM BIOL
JI Pharm. Biol.
PD JAN
PY 2013
VL 51
IS 1
BP 8
EP 12
DI 10.3109/13880209.2012.697175
PG 5
WC Plant Sciences; Medical Laboratory Technology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Medical Laboratory Technology; Pharmacology & Pharmacy
GA 059MD
UT WOS:000312708600002
PM 22971213
OA Bronze
DA 2025-06-11
ER

PT J
AU Soares, MB
   Ramalho, JB
   Izaguirry, AP
   Pavin, NF
   Spiazzi, CC
   Schimidt, HL
   Mello-Carpes, PB
   Santos, FW
AF Soares, Melina Bucco
   Ramalho, Juliana Bernera
   Izaguirry, Aryele Pinto
   Pavin, Natasha Frasson
   Spiazzi, Cristiano Chiapinotto
   Schimidt, Helen Lidiane
   Mello-Carpes, Pamela Billig
   Santos, Francielli Weber
TI Comparative effect of Camellia sinensis teas on object
   recognition test deficit and metabolic changes induced by cafeteria diet
SO NUTRITIONAL NEUROSCIENCE
LA English
DT Article
DE Camellia sinensis; Cafeteria diet; Memory deficits; White tea; Green
   tea; Red tea; Black tea; Oxidative stress
ID HIGH-FAT DIET; PREVENTS MEMORY DEFICITS; GREEN TEA; OXIDATIVE STRESS;
   PHYSICAL-EXERCISE; LIPID-METABOLISM; OBESITY; HIPPOCAMPUS; ANTIOXIDANT;
   LIVER
AB Objectives: Consumption of high-fat and high-sugar diets in Western countries has increased significantly causing major global health problems including metabolic syndrome and obesity. In addition, studies have suggested that obesity can lead to learning and memory deficits. In this context, the use of natural compounds with low costs, minor side effects and increased antioxidant activity, such as teas, could reduce the damages induced by obesity. We investigated the effect of white, green, red, and black teas (Camellia sinensis) and their possible neuroprotective mechanisms in an experimental obesity model induced by a cafeteria diet (CD). Methods: Female Swiss mice (20-30 g) were used; they received a normal diet or a hypercaloric diet (CD) during 8 weeks. Concomitantly, some mice received orally white, green, red, or black teas (1% dose) or water. Results: The mice subjected to CD showed weight gain, body fat accumulation, increased glucose, cholesterol, and triglycerides, associated to recognition memory deficits and increased reactive species (RS) levels and acetylcholinesterase (AChE) activity in the hippocampus. All teas significantly reduced AChE activity and partially reduced fat accumulation. Green and red teas reduced memory deficit. White, green, and black teas reduced RS levels, while only green and black tea reduced plasma triglyceride levels. Discussion: According to the results obtained it is possible to conclude that green tea was better than other teas in reducing effects of the CD model, being able to protect a greater number of parameters.
C1 [Soares, Melina Bucco; Ramalho, Juliana Bernera; Izaguirry, Aryele Pinto; Pavin, Natasha Frasson; Spiazzi, Cristiano Chiapinotto; Santos, Francielli Weber] Univ Fed Pampa, Lab Biotecnol Reprod Biotech, Campus Uruguaiana, BR-97500970 Uruguaiana, RS, Brazil.
   [Schimidt, Helen Lidiane] Fed Univ Pampa, Appl Neuromech Res Grp, BR-97500970 Uruguaiana, RS, Brazil.
   [Mello-Carpes, Pamela Billig] Fed Univ Pampa, Physiol Res Grp, BR-97500970 Uruguaiana, RS, Brazil.
C3 Universidade Federal do Pampa; Universidade Federal do Pampa;
   Universidade Federal do Pampa
RP Santos, FW (corresponding author), Univ Fed Pampa UNIPAMPA, Campus Uruguaiana, BR-97500970 Uruguaiana, RS, Brazil.
EM francielliweber@yahoo.com.br
RI Mello-Carpes, Pamela/AAM-7404-2020; Cibin, Francielli/AAW-3973-2020;
   Billig Mello-Carpes, Pamela/O-2118-2017; Schimidt, Helen
   Lidiane/F-5926-2019
OI Billig Mello-Carpes, Pamela/0000-0002-9008-2091; Santos Cibin,
   Francielli Weber/0000-0003-2178-1857; Schimidt, Helen
   Lidiane/0000-0003-4704-0897
FU CAPES; FAPERGS
FX CAPES and FAPERGS are acknowledged for financial support (M.Sc.
   Fellowship) to N.F.P, H.L.S. and A. P.
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NR 78
TC 13
Z9 13
U1 1
U2 17
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1028-415X
EI 1476-8305
J9 NUTR NEUROSCI
JI Nutr. Neurosci.
PD AUG 3
PY 2019
VL 22
IS 8
BP 531
EP 540
DI 10.1080/1028415X.2017.1418726
PG 10
WC Neurosciences; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Nutrition & Dietetics
GA IG1FH
UT WOS:000473535400001
PM 29280418
DA 2025-06-11
ER

PT J
AU Szewczyk-Golec, K
   Wozniak, A
   Reiter, RJ
AF Szewczyk-Golec, Karolina
   Wozniak, Alina
   Reiter, Russel J.
TI Inter-relationships of the chronobiotic, melatonin, with leptin and
   adiponectin: implications for obesity
SO JOURNAL OF PINEAL RESEARCH
LA English
DT Review
DE adipokines; adiponectin; chronobiology; leptin; melatonin; obesity;
   white adipose tissue
ID BROWN ADIPOSE-TISSUE; HIGH-FAT DIET; SHORT-SLEEP DURATION; BODY-WEIGHT;
   OXIDATIVE STRESS; GENE-EXPRESSION; PLASMA LEPTIN; VISCERAL FAT;
   FOOD-INTAKE; METABOLIC SYNDROME
AB Obesity and its medical complications represent a significant problem throughout the world. In recent decades, mechanisms underlying the progression of obesity have been intensively examined. The involvement of both the behavioral aspects, such as calorie-rich diet, low physical activity and sleep deprivation, and the intrinsic factors, including adipose tissue deregulation, chronic inflammation, oxidative stress, and chronodisruption, has been identified. The circadian disturbances of the adipose tissue endocrine function have been correlated with obesity. Leptin and adiponectin are adipokines strongly associated with glucose and lipid metabolism and with energy balance. Their synthesis and secretion display circadian rhythms that are disturbed in the obese state. Hyperleptinemia resulting in leptin resistance, and hypo-adiponectinemia have been linked to the pathophysiology of the obesity-related disorders. A deficiency of melatonin, one of the consequences of sleep deprivation, has also been demonstrated to correlate with obesity. Melatonin is a pineal secretory product involved in numerous actions, such as regulation of internal biological clocks and energy metabolism, and it functions as an antioxidant and as an anti-inflammatory agent. There exists a substantial amount of evidence supporting the beneficial effects of melatonin supplementation on obesity and its complications. In the current review, the results of studies related to the interactions between melatonin, and both leptin and adiponectin are discussed. Despite the existence of some inconsistencies, melatonin has been found to normalize the expression and secretion patterns of both adipokines. These results support the concept of melatonin as a potential therapeutic agent for obesity and related disorders.
C1 [Szewczyk-Golec, Karolina; Wozniak, Alina] Nicholas Copernicus Univ, Chair Med Biol, Ludwik Rydygier Coll Med, PL-85092 Bydgoszcz, Poland.
   [Reiter, Russel J.] Univ Texas Hlth Sci Ctr San Antonio, Dept Cellular & Struct Biol, San Antonio, TX 78229 USA.
C3 Nicolaus Copernicus University; University of Texas System; University
   of Texas Health Science Center at San Antonio
RP Szewczyk-Golec, K (corresponding author), Nicholas Copernicus Univ, Chair Med Biol, Ludwik Rydygier Coll Med, Karlowicza 24, PL-85092 Bydgoszcz, Poland.
EM karosz@cm.umk.pl
RI Woźniak, Alina/H-4699-2014; Reiter, Russel/D-3221-2009; Szewczyk-Golec,
   Karolina/E-9110-2014
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NR 185
TC 109
Z9 119
U1 0
U2 72
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0742-3098
EI 1600-079X
J9 J PINEAL RES
JI J. Pineal Res.
PD OCT
PY 2015
VL 59
IS 3
BP 277
EP 291
DI 10.1111/jpi.12257
PG 15
WC Endocrinology & Metabolism; Neurosciences; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Physiology
GA CS3IX
UT WOS:000361967300001
PM 26103557
OA Bronze
DA 2025-06-11
ER

PT J
AU Winchester, L
   Veeranki, S
   Givvimani, S
   Tyagi, SC
AF Winchester, Lee
   Veeranki, Sudhakar
   Givvimani, Srikanth
   Tyagi, Suresh C.
TI Exercise mitigates the adverse effects of hyperhomocysteinemia on
   macrophages, MMP-9, skeletal muscle, and white adipocytes
SO CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
LA English
DT Review
DE homocysteine; macrophage; exercise; cardiovascular; GPCR; MMP-9;
   skeletal muscle; PPAR
ID ELEVATED PLASMA HOMOCYSTEINE; ENDOPLASMIC-RETICULUM STRESS; ENDOTHELIAL
   GROWTH-FACTOR; TYPE-2 DIABETES-MELLITUS; INDUCED OXIDATIVE STRESS;
   PHYSICAL-EXERCISE; INDUCED ANGIOGENESIS; MURINE MACROPHAGES; M2
   MACROPHAGES; ADIPOSE-TISSUE
AB Regular exercise is a great medicine with its benefits encompassing everything from prevention of cardiovascular risk to alleviation of different muscular myopathies. Interestingly, elevated levels of homocysteine (Hcy), also known as hyperhomocysteinemia (HHcy), antagonizes beta-2 adrenergic receptors (beta(2)AR), gamma amino butyric acid (GABA), and peroxisome proliferator-activated receptor-gamma (PPAR gamma) receptors. HHcy also stimulates an elevation of the M1/M2 macrophage ratio, resulting in a more inflammatory profile. In this review we discuss several potential targets altered by HHcy that result in myopathy and excessive fat accumulation. Several of these HHcy mediated changes can be countered by exercise and culminate into mitigation of HHcy induced myopathy and metabolic syndrome. We suggest that exercise directly impacts levels of Hcy, matrix metalloproteinase 9 (MMP-9), macrophages, and G-protein coupled receptors (GPCRs, especially G(s)). While HHcy promotes the M1 macrophage phenotype, it appears that exercise may diminish the M1/M2 ratio, resulting in a less inflammatory phenotype. HHcy through its influence on GPCRs, specifically beta(2)AR, PPAR gamma and GABA receptors, promotes accumulation of white fat, whereas exercise enhances the browning of white fat and counters HHcy-mediated effects on GPCRs. Alleviation of HHcy-associated pathologies with exercise also includes reversal of excessive MMP-9 activation. Moreover, exercise, by reducing plasma Hcy levels, may prevent skeletal muscle myopathy, improve exercise capacity and rescue the obese phenotype. The purpose of this review is to summarize the pathological conditions surrounding HHcy and to clarify the importance of regular exercise as a method of disease prevention.
C1 [Winchester, Lee; Veeranki, Sudhakar; Givvimani, Srikanth; Tyagi, Suresh C.] Univ Louisville, Dept Physiol & Biophys, Louisville, KY 40202 USA.
C3 University of Louisville
RP Tyagi, SC (corresponding author), Univ Louisville, Dept Physiol & Biophys, Louisville, KY 40202 USA.
EM suresh.tyagi@louisville.edu
RI Winchester, Lee/ABD-6479-2021
OI Winchester, Lee/0000-0001-8443-8429
FU US National Institutes for Health [HL4718, HL108621]
FX Part of this research is supported by grants from the US National
   Institutes for Health: HL4718 and HL108621.
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NR 90
TC 82
Z9 96
U1 1
U2 16
PU CANADIAN SCIENCE PUBLISHING
PI OTTAWA
PA 65 AURIGA DR, SUITE 203, OTTAWA, ON K2E 7W6, CANADA
SN 0008-4212
EI 1205-7541
J9 CAN J PHYSIOL PHARM
JI Can. J. Physiol. Pharmacol.
PD JUL
PY 2014
VL 92
IS 7
BP 575
EP 582
DI 10.1139/cjpp-2014-0059
PG 8
WC Pharmacology & Pharmacy; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Physiology
GA AK8YB
UT WOS:000338713600009
PM 24923386
DA 2025-06-11
ER

PT J
AU Feuer, SK
   Liu, XW
   Donjacour, A
   Lin, W
   Simbulan, RK
   Giritharan, G
   Delle Piane, L
   Kolahi, K
   Ameri, K
   Maltepe, E
   Rinaudo, PF
AF Feuer, Sky K.
   Liu, Xiaowei
   Donjacour, Annemarie
   Lin, Wingka
   Simbulan, Rhodel K.
   Giritharan, Gnanaratnam
   Delle Piane, Luisa
   Kolahi, Kevin
   Ameri, Kurosh
   Maltepe, Emin
   Rinaudo, Paolo F.
TI Use of a Mouse In Vitro Fertilization Model to Understand the
   Developmental Origins of Health and Disease Hypothesis
SO ENDOCRINOLOGY
LA English
DT Article
ID THIOREDOXIN-INTERACTING PROTEIN; GENE-EXPRESSION;
   MITOCHONDRIAL-FUNCTION; MOLECULAR-MECHANISMS; METABOLIC SIGNATURE;
   INSULIN-RESISTANCE; CHILDHOOD GROWTH; BIRTH-WEIGHT; BETA-CELLS; EMBRYOS
AB The Developmental Origins of Health and Disease hypothesis holds that alterations to homeostasis during critical periods of development can predispose individuals to adult-onset chronic diseases such as diabetes and metabolic syndrome. It remains controversial whether preimplantation embryo manipulation, clinically used to treat patients with infertility, disturbs homeostasis and affects long-term growth and metabolism. To address this controversy, we have assessed the effects of in vitro fertilization (IVF) on postnatal physiology in mice. We demonstrate that IVF and embryo culture, even under conditions considered optimal for mouse embryo culture, alter postnatal growth trajectory, fat accumulation, and glucose metabolism in adult mice. Unbiased metabolic profiling in serum and microarray analysis of pancreatic islets and insulin sensitive tissues (liver, skeletal muscle, and adipose tissue) revealed broad changes in metabolic homeostasis, characterized by systemic oxidative stress and mitochondrial dysfunction. Adopting a candidate approach, we identify thioredoxin-interacting protein (TXNIP), a key molecule involved in integrating cellular nutritional and oxidative states with metabolic response, as a marker for preimplantation stress and demonstrate tissue-specific epigenetic and transcriptional TXNIP misregulation in selected adult tissues. Importantly, dysregulation of TXNIP expression is associated with enrichment for H4 acetylation at the Txnip promoter that persists from the blastocyst stage through adulthood in adipose tissue. Our data support the vulnerability of preimplantation embryos to environmental disturbance and demonstrate that conception by IVF can reprogram metabolic homeostasis through metabolic, transcriptional, and epigenetic mechanisms with lasting effects for adult growth and fitness. This study has wide clinical relevance and underscores the importance of continued follow-up of IVF-conceived offspring.
C1 [Feuer, Sky K.; Liu, Xiaowei; Donjacour, Annemarie; Simbulan, Rhodel K.; Giritharan, Gnanaratnam; Delle Piane, Luisa; Kolahi, Kevin; Rinaudo, Paolo F.] Univ Calif San Francisco, Dept Obstet Gynecol & Reprod Sci, San Francisco, CA 94143 USA.
   [Ameri, Kurosh; Maltepe, Emin] Univ Calif San Francisco, Dept Pediat, San Francisco, CA 94143 USA.
   [Giritharan, Gnanaratnam] Nevada Ctr Reprod Med, Reno, NV 89511 USA.
   [Delle Piane, Luisa] Univ Turin, Dept Obstet & Gynecol, Turin, Italy.
   [Kolahi, Kevin] Oregon Hlth & Sci Univ, Portland, OR 97239 USA.
C3 University of California System; University of California San Francisco;
   University of California System; University of California San Francisco;
   University of Turin; Oregon Health & Science University
RP Rinaudo, PF (corresponding author), Univ Calif San Francisco, San Francisco, CA 94115 USA.
EM rinaudop@obgyn.ucsf.edu
FU National Institute of Child Health and Human Development (NICHD) [RO1:
   HD 062803-01A1]; American Diabetes Association grant; National Institute
   of Health (NIH) training fellowship [5T32DK007418-32]; California
   Institute for Regenerative Medicine [TB1-01194]; Eunice Kennedy Shriver
   National Institute of Child Health and Human Development [R01HD072455]
   Funding Source: NIH RePORTER; National Institute of Diabetes and
   Digestive and Kidney Diseases [T32DK007418] Funding Source: NIH RePORTER
FX This work was supported by a National Institute of Child Health and
   Human Development (NICHD) grant (RO1:HD 062803-01A1) and American
   Diabetes Association grant (to P.F.R.). S.K.F. was supported by a
   National Institute of Health (NIH) training fellowship
   (5T32DK007418-32). R.K.S. was supported by the California Institute for
   Regenerative Medicine (TB1-01194).
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NR 62
TC 106
Z9 116
U1 0
U2 14
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0013-7227
EI 1945-7170
J9 ENDOCRINOLOGY
JI Endocrinology
PD MAY
PY 2014
VL 155
IS 5
BP 1956
EP 1969
DI 10.1210/en.2013-2081
PG 14
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA AP8PY
UT WOS:000342342200036
PM 24684304
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Krautbauer, S
   Eisinger, K
   Neumeier, M
   Hader, Y
   Buettner, R
   Schmid, PM
   Aslanidis, C
   Buechler, C
AF Krautbauer, Sabrina
   Eisinger, Kristina
   Neumeier, Markus
   Hader, Yvonne
   Buettner, Roland
   Schmid, Peter M.
   Aslanidis, Charalampos
   Buechler, Christa
TI Free Fatty Acids, Lipopolysaccharide and IL-1α Induce Adipocyte
   Manganese Superoxide Dismutase Which Is Increased in Visceral Adipose
   Tissues of Obese Rodents
SO PLOS ONE
LA English
DT Article
ID TUMOR-NECROSIS-FACTOR; INSULIN-RESISTANCE; OXIDATIVE STRESS; METABOLIC
   SYNDROME; MITOCHONDRIAL DYSFUNCTION; ADIPONECTIN RELEASE; 3T3-L1
   ADIPOCYTES; GENE-EXPRESSION; IN-VITRO; MICE
AB Excess fat storage in adipocytes is associated with increased generation of reactive oxygen species (ROS) and impaired activity of antioxidant mechanisms. Manganese superoxide dismutase (MnSOD) is a mitochondrial enzyme involved in detoxification of ROS, and objective of the current study is to analyze expression and regulation of MnSOD in obesity. MnSOD is increased in visceral but not subcutaneous fat depots of rodents kept on high fat diets (HFD) and ob/ob mice. MnSOD is elevated in visceral adipocytes of fat fed mice and exposure of differentiating 3T3-L1 cells to lipopolysaccharide, IL-1 alpha, saturated, monounsaturated and polyunsaturated free fatty acids (FFA) upregulates its level. FFA do not alter cytochrome oxidase 4 arguing against overall induction of mitochondrial enzymes. Upregulation of MnSOD in fat loaded cells is not mediated by IL-6, TNF or sterol regulatory element binding protein 2 which are induced in these cells. MnSOD is similarly abundant in perirenal fat of Zucker diabetic rats and non-diabetic animals with similar body weight and glucose has no effect on MnSOD in 3T3-L1 cells. To evaluate whether MnSOD affects adipocyte fat storage, MnSOD was knocked-down in adipocytes for the last three days of differentiation and in mature adipocytes. Knock-down of MnSOD does neither alter lipid storage nor viability of these cells. Heme oxygenase-1 which is induced upon oxidative stress is not altered while antioxidative capacity of the cells is modestly reduced. Current data show that inflammation and excess triglyceride storage raise adipocyte MnSOD which is induced in epididymal adipocytes in obesity.
C1 [Krautbauer, Sabrina; Eisinger, Kristina; Neumeier, Markus; Hader, Yvonne; Buettner, Roland; Buechler, Christa] Regensburg Univ Hosp, Dept Internal Med 1, Regensburg, Germany.
   [Schmid, Peter M.] Regensburg Univ Hosp, Dept Internal Med 2, Regensburg, Germany.
   [Aslanidis, Charalampos] Regensburg Univ Hosp, Inst Clin Chem & Lab Med, Regensburg, Germany.
C3 University of Regensburg; University of Regensburg; University of
   Regensburg
RP Buechler, C (corresponding author), Regensburg Univ Hosp, Dept Internal Med 1, Regensburg, Germany.
EM christa.buechler@klinik.uni-regensburg.de
FU Deutsche Forschungsgemeinschaft
FX This study was partly supported by the Deutsche Forschungsgemeinschaft.
   The funders had no role in study design, data collection and analysis,
   decision to publish, or preparation of the manuscript.
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NR 58
TC 25
Z9 26
U1 0
U2 7
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JAN 24
PY 2014
VL 9
IS 1
AR e86866
DI 10.1371/journal.pone.0086866
PG 10
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 298QQ
UT WOS:000330339800066
PM 24475187
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Karppi, J
   Laukkanen, JA
   Kurl, S
AF Karppi, Jouni
   Laukkanen, Jari A.
   Kurl, Sudhir
TI Plasma lutein and zeaxanthin and the risk of age-related nuclear
   cataract among the elderly Finnish population
SO BRITISH JOURNAL OF NUTRITION
LA English
DT Article
DE Lutein; Zeaxanthin; Carotenoids; Age-related nuclear cataract; Elderly
   population
ID VISUAL IMPAIRMENT; SERUM CAROTENOIDS; OXIDATIVE STRESS; METABOLIC
   SYNDROME; NUTRIENT INTAKE; VITAMIN-C; DISEASE; TOCOPHEROLS; PREVALENCE;
   KINETICS
AB Oxidative stress plays an important role in cataractogenesis. Previous studies have shown that long-term dietary intake of antioxidants (lutein and zeaxanthin) may decrease the risk of age-related cataracts. The aim of the present study was to examine whether plasma concentrations of lutein and zeaxanthin are related to age-related nuclear cataract in the elderly population. Subjects were participants in the Kuopio Ischaemic Heart Disease Risk Factor Study and they were classified into tertiles according to plasma concentrations of lutein and zeaxanthin. The association of plasma lutein and zeaxanthin concentrations with age-related nuclear cataract in 1689 elderly subjects (aged 61-80 years) was investigated in the present cross-sectional study by using the Cox proportional hazards model. A total of 113 cases of incident age-related cataracts were confirmed, of which 108 cases were nuclear cataracts. After adjustment for age, examination year, sex, BMI smoking, alcohol consumption, serum LDL-cholesterol, serum HDL-cholesterol, years of education, use of oral corticosteroids, history of diabetes and history of hypertension with current use of antihypertensive medication, subjects in the highest tertiles of plasma concentrations of lutein and zeaxanthin had 42 and 410/0 lower risks of nuclear cataract, respectively, compared with those in the lowest tertiles (relative risk (RR) = 0-58, 95% CI 0.35, 0.98; P=0-041 for lutein and RR = 0.59, 95% CI 0-35, 0-99; P=0-046 for zeaxanthin). In conclusion, we suggest that high plasma concentrations of lutein and zeaxanthin were associated with a decreased risk of age-related nuclear cataract in the elderly population.
C1 [Karppi, Jouni; Laukkanen, Jari A.; Kurl, Sudhir] Univ Eastern Finland, Dept Med, Inst Publ Hlth & Clin Nutr, FI-70211 Kuopio, Finland.
   [Laukkanen, Jari A.] Lapland Cent Hosp, Dept Internal Med, FI-96101 Rovaniemi, Finland.
C3 University of Eastern Finland
RP Karppi, J (corresponding author), Univ Eastern Finland, Dept Med, Inst Publ Hlth & Clin Nutr, POB 1627, FI-70211 Kuopio, Finland.
EM jouni.karppi@uef.fi
RI Laukkanen, Jari/N-2196-2019; Laukkanen, Jari/I-4528-2017
OI Laukkanen, Jari/0000-0002-3738-1586
FU University of Eastern Finland
FX The authors acknowledge the staff of the Institute of Public Health and
   Clinical Nutrition at the University of Eastern Finland for helping with
   data collection. The contribution of each author was as follows: J. K.
   performed the biochemical and statistical analyses, and contributed to
   the writing of the manuscript; J. A. L. and S. K. were involved in the
   commentary of the manuscript and helping with the statistical analyses.
   Financial support from the University of Eastern Finland is gratefully
   acknowledged. The authors thank Kimmo Ronkainen for help in the
   statistical analyses. None of the authors has a personal or financial
   conflict of interest.
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NR 35
TC 35
Z9 39
U1 0
U2 21
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1145
EI 1475-2662
J9 BRIT J NUTR
JI Br. J. Nutr.
PD JUL 14
PY 2012
VL 108
IS 1
BP 148
EP 154
DI 10.1017/S0007114511005332
PG 7
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 977PL
UT WOS:000306676800016
PM 22005336
OA Bronze
DA 2025-06-11
ER

PT J
AU Hirata, A
   Maeda, N
   Nakatsuji, H
   Hiuge-Shimizu, A
   Okada, T
   Funahashi, T
   Shimomura, I
AF Hirata, Ayumu
   Maeda, Norikazu
   Nakatsuji, Hideaki
   Hiuge-Shimizu, Aki
   Okada, Takuya
   Funahashi, Tohru
   Shimomura, Iichiro
TI Contribution of glucocorticoid-mineralocorticoid receptor pathway on the
   obesity-related adipocyte dysfunction
SO BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
LA English
DT Article
DE Mineralocorticoid receptor; Glucocorticoid; Obesity; Oxidative stress;
   Adiponectin
ID 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1; ADIPOSE-TISSUE; METABOLIC
   SYNDROME; OXIDATIVE STRESS; ADIPONECTIN; BLOCKADE; EXPRESSION; IMPACT;
   MUSCLE; GAMMA
AB Aims: Mineralocorticoid receptor (MR) blockade ameliorated insulin resistance with improvements in adipocytokine dysregulation, inflammation, and excess of reactive oxygen species (ROS) in obese adipose tissue and adipocytes, but its mechanism has not been clarified. The 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1), producing active glucocorticoids, is highly expressed in adipocytes and glucocorticoids bind to MR with higher affinity than to glucocorticoid receptor (GR). We investigated whether glucocorticoids effect on adipocytokines and ROS through MR in adipocytes. In addition, fat distributions of MR and GR were investigated in human subjects.
   Methods and Results: Corticoid receptors and their target genes were examined in adipose tissue of obese db/db mice. 3T3-L1 adipocytes were treated with glucocorticoids, H2O2, MR antagonist eplerenone (EP), GR antagonist RU486 (RU), MR-siRNA, and/or N-acetylcysteine. Human adipose tissues were obtained from seven patients who underwent abdominal surgery. The mRNA levels of MR and its target gene were higher in db/db mice than in control db/m + mice. In 3T3-L1 adipocytes, glucocorticoids, similar to H2O2, caused the dysregulation of mRNA levels of various genes related to adipocytokines and the increase of intracellular ROS. Such changes were rectified by MR blockade, not by GR antagonist. In human fat, MR mRNA level was increased in parallel with the increase of body mass index (BMI) and its increase was more significant in visceral fat, while there were no apparent correlations of GR mRNA level to BMI or fat distribution.
   Conclusion: Glucocorticoid-MR pathway may contribute to the obesity-related adipocytokine dysregulation and adipose ROS. (C) 2012 Elsevier Inc. All rights reserved.
C1 [Hirata, Ayumu; Maeda, Norikazu; Nakatsuji, Hideaki; Hiuge-Shimizu, Aki; Okada, Takuya; Funahashi, Tohru; Shimomura, Iichiro] Osaka Univ, Grad Sch Med, Dept Metab Med, Suita, Osaka 5650871, Japan.
C3 The University of Osaka
RP Hirata, A (corresponding author), Osaka Univ, Grad Sch Med, Dept Metab Med, 2-2-B5 Yamada Oka, Suita, Osaka 5650871, Japan.
EM hirata@endmet.med.osaka-u.ac.jp; norikazu_maeda@endmet.med.osaka-u.ac.jp
RI Maeda, Norikazu/LZI-4561-2025
FU [22590979];  [22126008]; Grants-in-Aid for Scientific Research
   [22590979] Funding Source: KAKEN
FX This work was supported by Grants-in-Aid for Scientific Research (C) No.
   22590979 (to N. M.), and Scientific Research on Innovative Areas No.
   22126008 (to T. F.).
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NR 24
TC 64
Z9 71
U1 0
U2 3
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0006-291X
J9 BIOCHEM BIOPH RES CO
JI Biochem. Biophys. Res. Commun.
PD MAR 9
PY 2012
VL 419
IS 2
BP 182
EP 187
DI 10.1016/j.bbrc.2012.01.139
PG 6
WC Biochemistry & Molecular Biology; Biophysics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics
GA 913XP
UT WOS:000301911000009
PM 22326264
DA 2025-06-11
ER

PT J
AU Lomba, A
   Milagro, FI
   García-Díaz, DF
   Marti, A
   Campión, J
   Martínez, JA
AF Lomba, Almudena
   Milagro, Fermin I.
   Garcia-Diaz, Diego F.
   Marti, Amelia
   Campion, Javier
   Alfredo Martinez, J.
TI Obesity induced by a pair-fed high fat sucrose diet: methylation and
   expression pattern of genes related to energy homeostasis
SO LIPIDS IN HEALTH AND DISEASE
LA English
DT Article
ID METABOLIC SYNDROME; OXIDATIVE STRESS; INSULIN-RESISTANCE; HEPATIC
   STEATOSIS; BLOOD-PRESSURE; SERUM-INSULIN; ZUCKER RATS; LIVER;
   GLUCOKINASE; MUSCLE
AB Background: The expression of some genes controlling energy homeostasis could be regulated by epigenetic mechanisms that may play a role in body weight regulation. Thus, it is known that various nutritional factors affect DNA methylation. In order to assess whether the macronutrient composition of the diet could be related to the epigenetic regulation of gene expression and with obesity development, we investigated the effects on methylation and expression patterns of two pair-fed isocaloric diets in rats: control (rich in starch) and HFS (rich in fat and sucrose).
   Results: The pair-fed HFS diet induced higher weight gain and adiposity as compared to the controls as well as liver triglyceride accumulation and oxidative stress. Feeding the HFS diet impaired glucose tolerance and serum triglycerides and cholesterol. Liver glucokinase expression, a key glycolytic gene, remained unaltered, as well as the mRNA values of fatty acid synthase and NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6 (NDUFB6) in liver and visceral adipocytes, which regulate lipogenesis and mitochondrial oxidative metabolism, respectively. Liver expression of hydroxyacyl-coenzyme A dehydrogenase (HADHB), a key gene of beta-oxidation pathway, was higher in the HFS-fed animals. However, the methylation status of CpG islands in HADHB and glucokinase genes remained unchanged after feeding the HFS diet.
   Conclusions: These results confirm that the distribution and type of macronutrients (starch vs. sucrose, and percent of fat) influence obesity onset and the associated metabolic complications. HFS diets produce obesity independently of total energy intake, although apparently no epigenetic (DNA methylation) changes accompanied the modifications observed in gene expression.
C1 [Lomba, Almudena; Milagro, Fermin I.; Garcia-Diaz, Diego F.; Marti, Amelia; Campion, Javier; Alfredo Martinez, J.] Univ Navarra, Dept Nutr & Food Sci, E-31080 Pamplona, Spain.
C3 University of Navarra
RP Martínez, JA (corresponding author), Univ Navarra, Dept Nutr & Food Sci, E-31080 Pamplona, Spain.
EM jalfmtz@unav.es
RI Garcia, Diego/AGH-4056-2022; Milagro, Fermin/F-2315-2015; Marti del
   Moral, Amelia/H-1192-2017; Martinez Hernandez, J Alfredo/K-8709-2014
OI Garcia-Diaz, Diego/0000-0002-7551-0553; Marti del Moral,
   Amelia/0000-0001-9832-7981; Martinez Hernandez, J
   Alfredo/0000-0001-5218-6941; Milagro, Fermin I./0000-0002-3228-9916
FU University of Navarra (Spain) [LE/97]; Ibercaja
FX The authors thank Linea Especial (LE/97) from the University of Navarra
   (Spain) for financial support. Almudena Lomba was the recipient of a
   pre-doctoral grant from Ibercaja. We also wish to acknowledge Enrique
   Buso, from the UCIM, University of Valencia, Spain, and to Paul Cordero,
   for his valuable help in the design of primers.
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NR 48
TC 64
Z9 74
U1 0
U2 7
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1476-511X
J9 LIPIDS HEALTH DIS
JI Lipids Health Dis.
PD JUN 9
PY 2010
VL 9
AR 60
DI 10.1186/1476-511X-9-60
PG 10
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA 632EV
UT WOS:000280404700001
PM 20534152
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Xi, L
   Qian, Z
   Xu, G
   Zhou, C
   Sun, S
AF Xi, L.
   Qian, Z.
   Xu, G.
   Zhou, C.
   Sun, S.
TI Crocetin attenuates palmitate-induced insulin insensitivity and
   disordered tumor necrosis factor-α and adiponectin expression in rat
   adipocytes
SO BRITISH JOURNAL OF PHARMACOLOGY
LA English
DT Article
DE crocetin; palmitate; insulin resistance; TNF-alpha; adiponectin;
   oxidative stress; NADPH oxidase; adipocyte
ID PROTEIN-KINASE-C; FREE FATTY-ACID; HUMAN SKELETAL-MUSCLE; OXIDATIVE
   STRESS; METABOLIC SYNDROME; 3T3-L1 ADIPOCYTES; GLUCOSE-TRANSPORT;
   N-ACETYLCYSTEINE; RESISTANCE; OBESITY
AB Background and purpose: A number of studies have implicated adipocyte-derived factors in the development of insulin resistance. Intracellular redox status has been reported to play a significant role in the modulation of insulin action. This study was designed to investigate the potential of crocetin, a potent antioxidant, to protect adipocytes against the induction of insulin insensitivity and disordered expression of tumor necrosis factor (TNF)-alpha and adiponectin in vitro.
   Experimental approach: We used palmitate to induce insulin resistance in freshly isolated rat adipocytes, and observed the effect of crocetin, N-acetylcysteine, diphenyleneiodonium, rotenone and oxypurinol. Insulin sensitivity was measured using 2-deoxy-D-[1-3H]-glucose uptake assay. Levels of glucose transporter 4, TNF- a and adiponectin were evaluated by immunoblot analysis, and levels of mRNA for TNF-alpha and adiponectin by reverse transcription-polymerase chain reaction analysis. Intracellular production of reactive oxygen species ( ROS) was determined spectrofluorometrically using 2 ', 7 '-dichlorofluorescin diacetate.
   Key results: Palmitate induced a 45% decrease in insulin- stimulated glucose uptake in adipocytes. The mRNA and protein expression of TNF-alpha were enhanced by 64% and 59% respectively whereas the mRNA and protein expression of adiponectin were reduced by 43% and 36% respectively by palmitate treatment. These changes were accompanied by a 54% increase in intracellular ROS levels. Crocetin, N-acetylcysteine and diphenyleneiodonium were found to attenuate these abnormalities.
   Conclusions and Implications: Crocetin blocked the impaired insulin-stimulated glucose uptake and disordered TNF-alpha and adiponectin expression induced by palmitate in rat adipocytes. Inactivation of NADPH oxidase may account for these observations.
C1 China Pharmaceut Univ, Dept Pharmacol, Nanjing 210009, Peoples R China.
   Nanjing Normal Univ, Coll Life Sci, Ctr New Drug Res & Dev, Nanjing, Peoples R China.
C3 China Pharmaceutical University; Nanjing Normal University
RP Qian, Z (corresponding author), China Pharmaceut Univ, Dept Pharmacol, POB 46,24 Tongjia Xiang, Nanjing 210009, Peoples R China.
EM zhiyu.qian@yahoo.com
RI xi, li/JZC-6279-2024
CR Ajuwon KM, 2005, J NUTR, V135, P1841, DOI 10.1093/jn/135.8.1841
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NR 45
TC 47
Z9 52
U1 0
U2 9
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0007-1188
J9 BRIT J PHARMACOL
JI Br. J. Pharmacol.
PD JUL
PY 2007
VL 151
IS 5
BP 610
EP 617
DI 10.1038/sj.bjp.0707276
PG 8
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 186EE
UT WOS:000247761100007
PM 17471172
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Dias, MRD
   Correia, TML
   Borges, JD
   dos Santos, LS
   Pereira, R
   da Silva, RAA
   Soares, TD
   Coqueiro, RD
   de Magalhaes, ACM
AF Dias, Maiara Raulina de Jesus
   Correia, Thiago Macedo Lopes
   Borges, Julia de Oliveira
   dos Santos, Larissa Silva
   Pereira, Rafael
   da Silva, Robson Amaro Augusto
   Soares, Telma de Jesus
   Coqueiro, Raildo da Silva
   de Magalhaes, Amelia Cristina Mendes
TI Therapeutic or lifelong training effects on pancreatic morphological and
   functional parameters in an animal model of aging and obesity
SO EXPERIMENTAL GERONTOLOGY
LA English
DT Article
DE Aged; Aerobic exercise; Lifelong exercise; Therapeutic exercise;
   Pancreas; Oxidative stress; Obese rats
ID HIGH-FAT-DIET; IMPROVES INSULIN SENSITIVITY; INCREASES ADIPONECTIN
   LEVELS; OXIDATIVE STRESS; HEME OXYGENASE-1; ADIPOSE-TISSUE; METABOLIC
   SYNDROME; SKELETAL-MUSCLE; BETA-CELL; CHRONIC INFLAMMATION
AB Aims: Obesity, aging, and physical training are factors influencing pancreatic functional and morphological parameters. Aiming to clarify the impact of the interaction of these factors, we analyzed the effect of therapeutic or lifelong physical training on body adiposity and pancreatic functional and morphological parameters of aged and obese rats.Methods: 24 male Wistar rats were (initial age = 4 months and final age = 14 months) randomly divided into three aged and obese experimental groups (n = 8/group): untrained, therapeutic trained, and lifelong trained. Body adiposity, plasmatic concentration and pancreatic immunostaining of insulin, markers of tissue inflam-mation, lipid peroxidation, activity and immunostaining of antioxidant enzymes, and parameters of pancreatic morphology were evaluated.Results: Lifelong physical training improved the body adiposity, plasmatic insulin concentration, and macrophage immunostaining in the pancreas. The animals submitted to therapeutic and lifelong training showed an increase in the density of the pancreatic islets; lower insulin, Nuclear Factor Kappa B (NF-& kappa;B), and Transforming Growth Factor beta (TGF-& beta;) immunostaining in the pancreatic parenchyma, as well as lower pancreatic tissue lipid peroxidation, lower fibrosis area, increased catalase and glutathione peroxidase (GPx) activity and increased heme oxygenase-1 (HO-1) immunostaining, with the greatest effect in the lifelong training group.Conclusion: Lifelong training promoted greater beneficial effects on the pancreatic functional and morphological parameters of aged and obese animals compared to therapeutic exercise.
C1 [Dias, Maiara Raulina de Jesus; Correia, Thiago Macedo Lopes; Borges, Julia de Oliveira; dos Santos, Larissa Silva; da Silva, Robson Amaro Augusto; Soares, Telma de Jesus; de Magalhaes, Amelia Cristina Mendes] Univ Fed Bahia, Inst Multidisciplinar Saude, Programa Posgrad Biociencias, Vitoria Da Conquista, BA, Brazil.
   [Pereira, Rafael; Coqueiro, Raildo da Silva] Univ Estadual Sudoeste Bahia, Dept Ciencias Biol, Nucleo Pesquisa Fisiol Integrat, Jequie, BA, Brazil.
   [de Magalhaes, Amelia Cristina Mendes] Univ Fed Bahia, Inst Multidisciplinar Saude, Rua Rio Contas 58, BR-45029094 Vitoria Da Conquista, BA, Brazil.
C3 Universidade Federal da Bahia; Universidade Estadual do Sudoeste da
   Bahia; Universidade Federal da Bahia
RP de Magalhaes, ACM (corresponding author), Univ Fed Bahia, Inst Multidisciplinar Saude, Rua Rio Contas 58, BR-45029094 Vitoria Da Conquista, BA, Brazil.
EM acmmcat@ufba.br
RI Pereira, Rafael/L-5195-2013; Pereira, Rafael/M-4393-2019
OI Cristina Mendes de Magalhaes, Amelia/0000-0002-5335-4844; Macedo Lopes
   Correia, Thiago/0000-0003-1654-614X
FU Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior - Brasil
   (CAPES) [001]; National Counsel of Technological and Scientific
   Development [481268/2013-8]; Foundation for Research Support of the
   State of Bahia [RED009/2014]
FX This study was financed in part by the Coordenacao de Aperfeicoamento de
   Pessoal de Nivel Superior - Brasil (CAPES) - Finance Code 001; the
   National Counsel of Technological and Scientific Development [grant
   numbers 481268/2013-8] ; and the Foundation for Research Support of the
   State of Bahia [grant number RED009/2014] . The funding sources had no
   involvement in data collection, analysis, and interpretation; in the
   report's writing; and in the decision to submit the article for
   publication. Thanks to Rubens Fernandes de Melo (FMRP-USP-BRAZIL) for
   performing the Masson's trichrome stain.
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NR 83
TC 2
Z9 2
U1 0
U2 6
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0531-5565
EI 1873-6815
J9 EXP GERONTOL
JI Exp. Gerontol.
PD MAY
PY 2023
VL 175
AR 112144
DI 10.1016/j.exger.2023.112144
EA MAR 2023
PG 11
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA M3FK0
UT WOS:001029067500001
PM 36907475
OA hybrid
DA 2025-06-11
ER

PT J
AU Memmert, S
   Damanaki, A
   Nogueira, AVB
   Nokhbehsaim, M
   Götz, W
   Cirelli, JA
   Rath-Deschner, B
   Jäger, A
   Deschner, J
AF Memmert, Svenja
   Damanaki, Anna
   Nogueira, Andressa V. B.
   Nokhbehsaim, Marjan
   Goetz, Werner
   Cirelli, Joni A.
   Rath-Deschner, Birgit
   Jaeger, Andreas
   Deschner, James
TI Regulation of tyrosine hydroxylase in periodontal fibroblasts and
   tissues by obesity-associated stimuli
SO CELL AND TISSUE RESEARCH
LA English
DT Article
DE Tyrosine hydroxylase; Periodontal ligament; Periodontitis; Obesity;
   Adipokines
ID GINGIVAL CREVICULAR FLUID; SERUM VISFATIN CONCENTRATION; METABOLIC
   SYNDROME; DIABETES-MELLITUS; LIGAMENT CELLS; CHRONIC STRESS;
   ANIMAL-MODELS; NORMAL-WEIGHT; LEPTIN; HEALTH
AB Tyrosine hydroxylase (TH) catalyzes the rate-limiting step in the synthesis of catecholamines and has been connected to aggravated progression of periodontal disease under chronic stress. Obesity is known to increase the risk of periodontitis and adipokines have been suggested to be a pathomechanistic link. This study examines if obesity-associated stimuli have regulatory effects on TH levels in periodontal cells and tissues. Human periodontal ligament fibroblasts were cultured in the presence of leptin or visfatin for up to 2days. Untreated cells served as control. TH regulation was analyzed by real-time PCR, immunocytochemistry and ELISA. TH gene expression in periodontal tissues of normal-weight and obese rodents was determined. Examination of gingival biopsies from rats and patients with and without periodontal disease was performed by real-time PCR or immunohistochemistry. For statistics, ANOVA and post hoc tests were applied (p<0.05). In vitro, TH gene expression and protein levels were increased by leptin and visfatin. In vivo, TH gene expression was upregulated in periodontal tissues of obese rodents as compared to normal-weight animals. Additionally, increased TH gene expression was found in rat gingival biopsies with experimental periodontitis. Human gingival biopsies from sites of periodontitis confirmed the animal data by demonstrating elevated TH levels at periodontally diseased sites. This study provides original evidence that obesity-associated stimuli induce a TH upregulation in periodontal cells and tissues. Since TH levels were also increased at periodontitis sites, our in vitro and animal findings suggest that this enzyme could represent a pathomechanism whereby obesity contributes to periodontitis.
C1 [Memmert, Svenja; Goetz, Werner; Rath-Deschner, Birgit; Jaeger, Andreas] Univ Bonn, Ctr Dentomaxillofacial Med, Dept Orthodont, Welschnonnenstr 17, D-53111 Bonn, Germany.
   [Memmert, Svenja; Nokhbehsaim, Marjan] Univ Bonn, Sect Expt Dentomaxillofacial Med, Ctr Dentomaxillofacial Med, Bonn, Germany.
   [Damanaki, Anna; Deschner, James] Johannes Gutenberg Univ Mainz, Univ Med Ctr Johannes Gutenberg, Dept Periodontol & Operat Dent, Mainz, Germany.
   [Nogueira, Andressa V. B.; Cirelli, Joni A.] Univ Estadual Paulista UNESP, Sch Dent Araraquara, Dept Diag & Surg, Araraquara, Brazil.
C3 University of Bonn; University of Bonn; Johannes Gutenberg University of
   Mainz; Universidade Estadual Paulista
RP Memmert, S (corresponding author), Univ Bonn, Ctr Dentomaxillofacial Med, Dept Orthodont, Welschnonnenstr 17, D-53111 Bonn, Germany.; Memmert, S (corresponding author), Univ Bonn, Sect Expt Dentomaxillofacial Med, Ctr Dentomaxillofacial Med, Bonn, Germany.
EM svenja.memmert@ukb.uni-bonn.de
RI Cirelli, Joni/AAG-7785-2019; BeiselMemmert, Svenja/KIL-4466-2024;
   DESCHNER, JAMES/AAW-3998-2021; Cirelli, Joni/D-5359-2012; Nogueira,
   Andressa V. B./H-3987-2014
OI Cirelli, Joni/0000-0002-7082-9290; Nogueira, Andressa V.
   B./0000-0002-2756-5947; Damanaki, Anna/0000-0002-2706-398X; Memmert,
   Svenja/0000-0002-8153-6610
FU Medical Faculty of the University of Bonn; German Orthodontic Society
   (DGKFO); German Research Foundation (DFG) [ME 4798/1-1]
FX This study was supported by the Medical Faculty of the University of
   Bonn, the German Orthodontic Society (DGKFO) and the German Research
   Foundation (DFG, ME 4798/1-1).
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NR 56
TC 7
Z9 7
U1 1
U2 6
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0302-766X
EI 1432-0878
J9 CELL TISSUE RES
JI Cell Tissue Res.
PD MAR
PY 2019
VL 375
IS 3
BP 619
EP 628
DI 10.1007/s00441-018-2941-8
PG 10
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA HN9QZ
UT WOS:000460535300005
PM 30361782
DA 2025-06-11
ER

PT J
AU Storniolo, CE
   Casillas, R
   Bulló, M
   Castañer, O
   Ros, E
   Saez, GT
   Toledo, E
   Estruch, R
   Ruiz-Gutiérrez, V
   Fitó, M
   Martínez-González, MA
   Salas-Salvadó, J
   Mitjavila, MT
   Moreno, JJ
AF Storniolo, C. E.
   Casillas, R.
   Bullo, M.
   Castaner, O.
   Ros, E.
   Saez, G. T.
   Toledo, E.
   Estruch, R.
   Ruiz-Gutierrez, V.
   Fito, M.
   Martinez-Gonzalez, M. A.
   Salas-Salvado, J.
   Mitjavila, M. T.
   Moreno, J. J.
TI A Mediterranean diet supplemented with extra virgin olive oil or nuts
   improves endothelial markers involved in blood pressure control in
   hypertensive women
SO EUROPEAN JOURNAL OF NUTRITION
LA English
DT Article
DE Endothelin-1; Hypertension; Nitric oxide; PREDIMED study; Oxidative
   stress
ID CARDIOVASCULAR RISK-FACTORS; NITRIC-OXIDE; METABOLIC SYNDROME; STYLE
   DIET; DYSFUNCTION; POLYPHENOLS; ARTERY; QUESTIONNAIRE; FRACTION; CELLS
AB Serum nitric oxide (NO) reduction and increased endothelin-1 (ET-1) play a pivotal role in endothelial dysfunction and hypertension. Considering that traditional Mediterranean diet (TMD) reduces blood pressure (BP), the aim of this study was to analyze whether TMD induced changes on endothelial physiology elements such as NO, ET-1 and ET-1 receptors which are involved in BP control.
   Non-smoking women with moderate hypertension were submitted for 1 year to interventions promoting adherence to the TMD, one supplemented with extra virgin olive oil (EVOO) and the other with nuts versus a control low-fat diet (30 participants/group). BP, NO, ET-1 and related gene expression as well as oxidative stress biomarkers were measured.
   Serum NO and systolic BP (SBP) or diastolic BP (DBP) were negatively associated at baseline, as well as between NO and ET-1. Our findings also showed a DBP reduction with both interventions. A negative correlation was observed between changes in NO metabolites concentration and SBP or DBP after the intervention with TMD + EVOO (p = 0.033 and p = 0.044, respectively). SBP reduction was related to an impairment of serum ET-1 concentrations after the intervention with TMD + nuts (p = 0.008). We also observed changes in eNOS, caveolin 2 and ET-1 receptors gene expression which are related to NO metabolites levels and BP.
   The changes in NO and ET-1 as well as ET-1 receptors gene expression explain, at least partially, the effect of EVOO or nuts on lowering BP among hypertensive women.
C1 [Storniolo, C. E.; Casillas, R.; Mitjavila, M. T.; Moreno, J. J.] Univ Barcelona, Dept Physiol, Barcelona, Spain.
   [Bullo, M.; Salas-Salvado, J.] Univ Rovira & Virgili, Human Nutr Unit, HSPV, Reus, Spain.
   [Castaner, O.; Fito, M.] IMIM Inst Recerca Hosp del Mar, Cardiovasc Risk & Nutr Res Grp, Barcelona, Spain.
   [Ros, E.] Hosp Clin Barcelona, Endocrinol & Nutr Serv, Barcelona, Spain.
   [Saez, G. T.] Univ Valencia, Dept Biochem & Mol Biol, Clin Anal Serv CDB HGUV, Valencia, Spain.
   [Toledo, E.; Martinez-Gonzalez, M. A.] Univ Navarra, Dept Prevent Med & Publ Hlth, Pamplona, Spain.
   [Estruch, R.] Univ Barcelona, Dept Internal Med, Barcelona, Spain.
   [Ruiz-Gutierrez, V.] CSIC, Inst Grasa, Seville, Spain.
   [Bullo, M.; Castaner, O.; Ros, E.; Saez, G. T.; Toledo, E.; Estruch, R.; Ruiz-Gutierrez, V.; Fito, M.; Martinez-Gonzalez, M. A.; Salas-Salvado, J.] Inst Salud Carlos III, Ctr Invest Biomed Red Fisiopatol Obesidad & Nutr, Madrid, Spain.
C3 University of Barcelona; Universitat Rovira i Virgili; Hospital del Mar
   Research Institute; University of Barcelona; Hospital Clinic de
   Barcelona; University of Valencia; University of Navarra; University of
   Barcelona; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC
   - Instituto de la Grasa (IG); CIBER - Centro de Investigacion Biomedica
   en Red; CIBEROBN; Instituto de Salud Carlos III
RP Moreno, JJ (corresponding author), Univ Barcelona, Dept Physiol, Barcelona, Spain.
EM jjmoreno@ub.edu
RI Castaner, Olga/F-1533-2013; Estruch, Ramon/AAZ-3723-2020;
   Martinez-Gonzalez, Miguel/AAE-7669-2019; Moreno, Juan/AAA-1312-2019;
   TORMO, GUILLERMO/AAB-2592-2019; Mitjavila, Maria/D-7474-2014;
   Salas-Salvado, Jordi/C-7229-2017; Bullo, Monica/F-2925-2016; Fito
   Colomer, Montse/C-1822-2012; Toledo, Estefania/H-6211-2014
OI Salas-Salvado, Jordi/0000-0003-2700-7459; Bullo,
   Monica/0000-0002-0218-7046; Ros, Emilio/0000-0002-2573-1294; Fito
   Colomer, Montse/0000-0002-1817-483X; Toledo,
   Estefania/0000-0002-6263-4434; Castaner Nino, Olga/0000-0003-3169-997X
FU Spanish Ministry of Health [FIS PI10/0082, G03/140, RD06/0045]; Fondo
   Europeo de Desarrollo Regional; Spanish Ministry of Science
   [BFU2007-61727/BFI]; Generalitat de Catalunya [2009SGR00438]
FX The authors thank the participants in the PREDIMED study for their
   continued collaboration. The Fundacion Patrimonio Comunal Olivarero,
   Hojiblanca SA (Malaga, Spain), California Walnut Commission (Sacramento,
   CA, USA), Borges SA (Reus, Spain) and Morella Nuts SA (Reus, Spain)
   donated the olive oil, walnuts, almonds and hazelnuts, respectively. We
   also thank the Scientific and Technical services of the University of
   Barcelona for malondialdehyde determinations. This study was supported
   by the Spanish Ministry of Health (FIS PI10/0082, G03/140, RD06/0045),
   Fondo Europeo de Desarrollo Regional, the Spanish Ministry of Science
   (BFU2007-61727/BFI) and the Generalitat de Catalunya (2009SGR00438).
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NR 44
TC 85
Z9 90
U1 0
U2 0
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1436-6207
EI 1436-6215
J9 EUR J NUTR
JI Eur. J. Nutr.
PD FEB
PY 2017
VL 56
IS 1
BP 89
EP 97
DI 10.1007/s00394-015-1060-5
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA EK8IW
UT WOS:000394168100008
PM 26450601
DA 2025-06-11
ER

PT J
AU Lui, MMS
   Lam, DCL
   Ip, MSM
AF Lui, Macy Mei-Sze
   Lam, David Chi-Leung
   Ip, Mary Sau-Man
TI Significance of endothelial dysfunction in sleep-related breathing
   disorder
SO RESPIROLOGY
LA English
DT Review
DE atherosclerosis; cardiovascular disease; endothelial function;
   obstructive sleep apnoea
ID POSITIVE AIRWAY PRESSURE; RANDOMIZED CONTROLLED-TRIAL; OXIDATIVE STRESS;
   PROGENITOR CELLS; METABOLIC SYNDROME; APNEA SYNDROME; CORONARY-ARTERIES;
   MANDIBULAR ADVANCEMENT; DEPENDENT VASODILATION; VASCULAR ENDOTHELIUM
AB The endothelium functions not only as a semi-selective barrier between body tissue and circulation; it also plays an active role in the maintenance of a healthy vasculature. Endothelial dysfunction is increasingly found to play a pivotal role in the pathogenesis of atherosclerosis. Impaired endothelium-dependent vasodilation, as a marker of endothelial dysfunction, predates and predicts cardiovascular disease. Endothelial dysfunction is thought to result from oxidative stress, inflammatory gene activation and cytokine cascade, as well as impairment of endothelial repair mechanisms. In the context of sleep-related breathing disorders, obstructive sleep apnoea (OSA) is postulated to contribute independently to cardiovascular morbidity and mortality. Thus, endothelial dysfunction is an important target of research in vascular pathogenesis and also serves as an intermediary outcome indicator in clinical trials evaluating cardiovascular sequelae in OSA. Basic or translational studies have identified cellular and molecular mechanisms of potential relevance to endothelial dysfunction in OSA, while epidemiological or clinical studies have shown endothelial dysfunction attributable to sleep-disordered breathing, which could improve with effective treatment of OSA. Endothelial dysfunction is poised to serve as a call for timely intervention with possibility of halting or even reverting vascular injury in sleep-related breathing disorders. Much remains to be explored about the complex pathways of endothelial dysfunction and its clinical manifestations in subjects with OSA, which are likely to involve multiple contributing factors. Evidence-based information will allow us to construct the framework for guiding individualized clinical management and public health strategies for OSA, as well as cardiometabolic diseases.
C1 [Lui, Macy Mei-Sze; Lam, David Chi-Leung; Ip, Mary Sau-Man] Univ Hong Kong, Queen Mary Hosp, Dept Med, Pokfulam, Hong Kong, Peoples R China.
C3 University of Hong Kong
RP Ip, MSM (corresponding author), Univ Hong Kong, Queen Mary Hosp, Dept Med, Pokfulam, Hong Kong, Peoples R China.
EM msmip@hkucc.hku.hk
RI Lam, David/AAI-3657-2020; /E-9868-2010; Ip, Mary Sau Man/C-4284-2009
OI /0000-0002-0004-2660; Lui, Macy/0000-0002-7150-9360; Ip, Mary Sau
   Man/0000-0002-8692-6933
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NR 82
TC 24
Z9 28
U1 0
U2 9
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1323-7799
J9 RESPIROLOGY
JI Respirology
PD JAN
PY 2013
VL 18
IS 1
BP 39
EP 46
DI 10.1111/j.1440-1843.2012.02212.x
PG 8
WC Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Respiratory System
GA 078RD
UT WOS:000314116100006
PM 22712467
OA Bronze
DA 2025-06-11
ER

PT J
AU Jiang, S
   Wang, ZG
   Riethoven, JJ
   Xia, YN
   Miner, J
   Fromm, M
AF Jiang, Shan
   Wang, Zhigang
   Riethoven, Jean-Jack
   Xia, Yuannan
   Miner, Jess
   Fromm, Michael
TI Conjugated Linoleic Acid Activates AMP-Activated Protein Kinase and
   Reduces Adiposity More Effectively When Used with Metformin in Mice
SO JOURNAL OF NUTRITION
LA English
DT Article
ID METABOLIC SYNDROME; 3T3-L1 PREADIPOCYTES; LIPID-METABOLISM;
   ENDOPLASMIC-RETICULUM; BODY-COMPOSITION; HUMAN ADIPOCYTES;
   GENE-EXPRESSION; STRESS-RESPONSE; GAMMA ACTIVITY; HEART-DISEASE
AB Trans-10, cis-12 (t10c12) conjugated linoleic acid (CLA) reduces lipid levels in adipocytes, but the mechanisms involved are still emerging. The hypotheses of this study were that t10c12 CLA treatment activated AMP-activated protein kinase (AMPK) and that the effectiveness of a low dose of t10c12 CLA would be increased when combined with an AMPK activator. We demonstrated t10c12 CLA, directly or indirectly, activated AMPK and increased the amount of phosphorylated acetyl-CoA carboxylase (ACC) in 3T3-L1 adipocytes. Compound C, a potent inhibitor of AMPK, attenuated the phosphorylation of ACC, integrated stress response (ISR), inflammatory response, reduction in key lipogenic transcription factors, and triglyceride (TG) reduction that otherwise occurred in t10c12 CLA-treated adipocytes. Treatment of adipocytes or mice with a low dose of t10c12 CLA in conjunction with the AMPK activator metformin resulted in more TG loss than treatment with the individual chemicals. Additionally, although an inflammatory response was required for robust TG reduction, the combination of t10c12 CLA with AMPK activators had a similar TG loss with a reduced inflammatory response. A microarray analysis of the transcriptional response to either t10c12 CLA, metformin, or the combination, indicated the responses were very similar, with a correlation coefficient of 0.91 or better for genes in the ISR or lipid-related pathways. Altogether, these results support our hypotheses that t10c12 CLA activates AMPK, directly or indirectly, and that metformin increases the effectiveness of t10c12 CLA in reducing TG amounts in adipocytes. J. Nutr. 139:2244-2251,2009.
C1 [Riethoven, Jean-Jack; Xia, Yuannan; Fromm, Michael] Univ Nebraska, Ctr Biotechnol, Lincoln, NE 68502 USA.
   [Jiang, Shan; Wang, Zhigang; Miner, Jess] Univ Nebraska, Dept Anim Sci, Lincoln, NE 68502 USA.
C3 University of Nebraska System; University of Nebraska Lincoln;
   University of Nebraska System; University of Nebraska Lincoln
RP Fromm, M (corresponding author), Univ Nebraska, Ctr Biotechnol, Lincoln, NE 68502 USA.
EM mfromm@unlnotes.unl.edu
RI Wang, Zhigang/MIQ-5751-2025
OI Riethoven, Jean-Jack/0000-0002-2709-7880
FU Agricultural Research Division Fellowships; University of Nebraska
   Lincoln Center for Biotechnology
FX Supported in part by Agricultural Research Division Fellowships (to S.J.
   and Z. W.) and by the University of Nebraska Lincoln Center for
   Biotechnology.
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NR 49
TC 20
Z9 25
U1 0
U2 10
PU AMER SOC NUTRITION-ASN
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-3166
EI 1541-6100
J9 J NUTR
JI J. Nutr.
PD DEC
PY 2009
VL 139
IS 12
BP 2244
EP 2251
DI 10.3945/jn.109.112417
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 528WY
UT WOS:000272478900004
PM 19828681
OA Bronze
DA 2025-06-11
ER

PT J
AU Primeaux, SD
   Tong, M
   Holmes, GM
AF Primeaux, Stefany D.
   Tong, Melissa
   Holmes, Gregory M.
TI Effects of chronic spinal cord injury on body weight and body
   composition in rats fed a standard chow diet
SO AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE
   PHYSIOLOGY
LA English
DT Article
DE metabolic syndrome; fat mass; lean body mass; weight loss; energy;
   balance
ID WHITE ADIPOSE-TISSUE; MONOZYGOTIC TWINS DISCORDANT; RESTING
   METABOLIC-RATE; CHRONIC STRESS; ENERGY-EXPENDITURE; LOCOMOTOR RECOVERY;
   RESTRAINT STRESS; PRESSURE SORES; COLD-EXPOSURE; FAT
AB The inability to maintain body weight within prescribed ranges occurs in a significant portion of the human spinal cord injury ( SCI) population. Using a rodent model of long-term high thoracic ( spinal level T3) spinal cord transection ( TX), we aimed to identify derangements in body weight, body composition, plasma insulin, glucose tolerance, and metabolic function, as measured by uncoupling protein 1 ( UCP1) expression in interscapular brown adipose tissue ( IBAT). Sixteen weeks after SCI, body weights of injured female rats stabilized and were significantly lower than surgical control animals. At the same time point, SCI rats had a significantly lower whole body fat: lean tissue mass ratio than controls, as measured indirectly by NMR. Despite lower body weight and fat mass, the cumulative consumption of standard laboratory chow ( 4.0 kcal/ g) and mean energy intake ( kcal center dot day(-1) center dot 100 g body wt(-1)) of chronic SCI rats was significantly more than controls. Glucose tolerance tests indicated a significant enhancement in glucose handling in 16-wk SCI rats, which were coupled with lower serum insulin levels. The post mortem weight of gonadal and retroperitoneal fat pads was significantly reduced after SCI and IBAT displayed significantly lower real-time PCR expression of UCP1 mRNA. The reduced fat mass and IBAT UCP1 mRNA expression are contraindicative of the cumulative caloric intake by the SCI rats. The prolonged postinjury loss of body weight, including fat mass, is not due to hypophagia but possibly to permanent changes in gastrointestinal transit and absorption, as well as whole body homeostatic mechanisms.
C1 Louisiana State Univ, Pennington Biomed Res Ctr, Neurotrauma & Nutr Lab, Baton Rouge, LA 70808 USA.
   Louisiana State Univ, Pennington Biomed Res Ctr, Dietary Obes Lab, Baton Rouge, LA 70808 USA.
C3 Louisiana State University System; Louisiana State University;
   Pennington Biomedical Research Center; Louisiana State University
   System; Louisiana State University; Pennington Biomedical Research
   Center
RP Holmes, GM (corresponding author), Louisiana State Univ, Pennington Biomed Res Ctr, Neurotrauma & Nutr Lab, 6400 Perkins Rd, Baton Rouge, LA 70808 USA.
EM HolmesGM@pbrc.edu
RI Primeaux, Stefany/NDT-4352-2025
FU NIDDK NIH HHS [DK 32089, P30 DK072476] Funding Source: Medline; ONDIEH
   CDC HHS [ND 49177] Funding Source: Medline
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NR 49
TC 41
Z9 49
U1 0
U2 8
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0363-6119
J9 AM J PHYSIOL-REG I
JI Am. J. Physiol.-Regul. Integr. Comp. Physiol.
PD SEP
PY 2007
VL 293
IS 3
BP R1102
EP R1109
DI 10.1152/ajpregu.00224.2007
PG 8
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA 206AJ
UT WOS:000249156000020
PM 17634202
DA 2025-06-11
ER

PT J
AU Ndlovu, SS
   Ghazi, T
   Chuturgoon, AA
AF Ndlovu, Siqiniseko S.
   Ghazi, Terisha
   Chuturgoon, Anil A.
TI The Potential of Moringa oleifera to Ameliorate HAART-Induced
   Pathophysiological Complications
SO CELLS
LA English
DT Review
DE HIV; HAART; pathophysiology; metabolic syndrome; Moringa oliefera
ID NF-KAPPA-B; ACTIVE ANTIRETROVIRAL THERAPY; HUMAN-IMMUNODEFICIENCY-VIRUS;
   INNATE IMMUNE ACTIVATION; OXIDATIVE STRESS; MITOCHONDRIAL TOXICITY;
   TENOFOVIR DISOPROXIL; ANTIOXIDANT ACTIVITY; CARDIOVASCULAR RISK;
   SIGNALING PATHWAY
AB Highly active antiretroviral therapy (HAART) comprises a combination of two or three antiretroviral (ARV) drugs that are administered together in a single tablet. These drugs target different steps within the human immunodeficiency virus (HIV) life cycle, providing either a synergistic or additive antiviral effect; this enhances the efficiency in which viral replication is suppressed. HIV cannot be completely eliminated, making HAART a lifetime treatment. With long-term HAART usage, an increasing number of patients experience a broadening array of complications, and this significantly affects their quality of life, despite cautious use. The mechanism through which ARV drugs induce toxicity is associated with metabolic complications such as mitochondrial dysfunction, oxidative stress, and inflammation. To address this, it is necessary to improve ARV drug formulation without compromising its efficacy; alternatively, safe supplementary medicine may be a suitable solution. The medicinal plant Moringa oleifera (MO) is considered one of the most important sources of novel nutritionally and pharmacologically active compounds that have been shown to prevent and treat various diseases. MO leaves are rich in polyphenols, vitamins, minerals, and tannins; studies have confirmed the therapeutic properties of MO. MO leaves provide powerful antioxidants, scavenge free radicals, promote carbohydrate metabolism, and repair DNA. MO also induces anti-inflammatory, hepatoprotective, anti-proliferative, and anti-mutagenic effects. Therefore, MO can be a source of affordable and safe supplement therapy for HAART-induced toxicity. This review highlights the potential of MO leaves to protect against HAART-induced toxicity in HIV patients.
C1 [Ndlovu, Siqiniseko S.; Ghazi, Terisha; Chuturgoon, Anil A.] Univ KwaZulu Natal, Sch Lab Med & Med Sci, Discipline Med Biochem, ZA-4041 Durban, South Africa.
C3 University of Kwazulu Natal
RP Ghazi, T; Chuturgoon, AA (corresponding author), Univ KwaZulu Natal, Sch Lab Med & Med Sci, Discipline Med Biochem, ZA-4041 Durban, South Africa.
EM ghazit@ukzn.ac.za; chutur@ukzn.ac.za
RI Chuturgoon, Anil/AAE-5068-2021; Ghazi, Terisha/AAU-5164-2021
OI Ghazi, Terisha/0000-0002-0179-213X; Ndlovu, Siqiniseko
   Sinikiwe/0000-0001-8963-5210
FU National Research Foundation Innovation Doctoral Scholarship [120820];
   University of KwaZulu Natal, College of Health Sciences Doctoral
   Research Scholarship
FX National Research Foundation Innovation Doctoral Scholarship (grant
   number: 120820). Grant sponsor: University of KwaZulu Natal, College of
   Health Sciences Doctoral Research Scholarship.
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NR 157
TC 3
Z9 3
U1 0
U2 3
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2073-4409
J9 CELLS-BASEL
JI Cells
PD OCT
PY 2022
VL 11
IS 19
AR 2981
DI 10.3390/cells11192981
PG 14
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA 5G0AL
UT WOS:000866670800001
PM 36230942
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Eller, OC
   Foright, RM
   Brake, AD
   Winter, MK
   Bantis, LE
   Morris, EM
   Thyfault, JP
   Christianson, JA
AF Eller, Olivia C.
   Foright, Rebecca M.
   Brake, Aaron D.
   Winter, Michelle K.
   Bantis, Leonidas E.
   Morris, E. Matthew
   Thyfault, John P.
   Christianson, Julie A.
TI An Omega-3-rich Anti-inflammatory Diet Improved Widespread Allodynia and
   Worsened Metabolic Outcomes in Adult Mice Exposed to Neonatal Maternal
   Separation
SO NEUROSCIENCE
LA English
DT Article
DE Chronic pain; Early life stress; Obesity; Nutrition; Inflammation
ID PITUITARY-ADRENAL AXIS; 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1;
   GREEN TEA POLYPHENOL; HIGH-FAT DIET; SEX-DIFFERENCES; THERMAL
   HYPERALGESIA; ATTENUATES OBESITY; FOOD-DEPRIVATION; MENTAL-DISORDERS;
   NEUROPATHIC PAIN
AB Inflammation plays a key role in the progression and maintenance of chronic pain, which impacts the lives of millions of Americans. Despite growing evidence that chronic pain can be improved by treating underlying inflammation, successful treatments are lacking and pharmaceutical interventions are limited due to drug side effects. Here we are testing whether a 'healthy human' diet (HHD), with or without anti-inflammatory components (HHAID), improves pain-like behaviors in a preclinical model of chronic widespread hypersensitivity induced by neonatal maternal separation (NMS). The HHD and HHAID are isocaloric and macronutrient-matched, have a low glycemic index, and fat content (35 kcal%) that is high in omega-3 fatty acids, while only the HHAID includes a combination of key anti-inflammatory compounds, at clinically relevant doses. Mice on these diets were compared to mice on a control diet with a macronutrient composition commonly used in rodents (20% protein, 70% carbohydrate, 10% fat). Our results demonstrate a benefit of the HHAID on pain-like behaviors in both male and female mice, despite increased caloric intake, adiposity, and weight gain. In female mice, HHAID specifically increased measures of metabolic syndrome and inflammation compared to the HHD and control diet groups. Male mice were susceptible to worsening metabolic measures on both the HHAID and HHD. This work highlights important sexual dimorphic outcomes related to early life stress exposure and dietary interventions, as well as a potential disconnect between improvements in pain-like behaviors and metabolic measures. (c) 2021 IBRO. Published by Elsevier Ltd. All rights reserved.
C1 [Eller, Olivia C.; Foright, Rebecca M.; Brake, Aaron D.; Christianson, Julie A.] Univ Kansas, Med Ctr, Sch Med, Dept Anat & Cell Biol, 3901 Rainbow Blvd,MS 3038, Kansas City, KS 66160 USA.
   [Winter, Michelle K.] Univ Kansas, Med Ctr, Sch Med, Kansas Intellectual & Dev Disabil Res Assoc, Kansas City, KS 66103 USA.
   [Bantis, Leonidas E.] Univ Kansas, Med Ctr, Sch Med, Dept Biostat & Data Sci, Kansas City, KS 66103 USA.
   [Morris, E. Matthew; Thyfault, John P.] Univ Kansas, Med Ctr, Sch Med, Dept Mol & Integrat Physiol, Kansas City, KS 66103 USA.
   [Christianson, Julie A.] Univ Kansas, Med Ctr, Sch Med, Dept Anesthesiol, Kansas City, KS 66103 USA.
   Kansas City VA Med Ctr, Res Serv, Kansas City, KS USA.
C3 University of Kansas; University of Kansas Medical Center; University of
   Kansas; University of Kansas Medical Center; University of Kansas;
   University of Kansas Medical Center; University of Kansas; University of
   Kansas Medical Center; University of Kansas; University of Kansas
   Medical Center
RP Christianson, JA (corresponding author), Univ Kansas, Med Ctr, Sch Med, Dept Anat & Cell Biol, 3901 Rainbow Blvd,MS 3038, Kansas City, KS 66160 USA.
EM jchristianson@kumc.edu
RI Thyfault, John/JMB-3070-2023; Eller-Smith, Olivia/IWE-4667-2023
OI Thyfault, John/0000-0001-7920-7466; Christianson,
   Julie/0000-0003-4117-5192; Morris, E. Matthew/0000-0001-7046-3623
FU National Institutes of Health (NIH) [R01DK099611, R01DK103872,
   R01AR071263, K01DK112967, T32HD057850, P20GM103418, U54HD090216]; VA
   Merit Review [1I01BX002567]; National Institute of Arthritis and
   Musculoskeletal and Skin Diseases [R01AR071263] Funding Source: NIH
   RePORTER; National Institute of Diabetes and Digestive and Kidney
   Diseases [K01DK112967] Funding Source: NIH RePORTER
FX This work was funded by the National Institutes of Health (NIH) grants
   R01DK099611 (JAC) , R01DK103872 (JAC) , R01AR071263 (JPT) , K01DK112967
   (EMM) , T32HD057850 (OCE) , P20GM103418 (Idea Network of Biomedical
   Research Excellence (INBRE) Program) , U54HD090216 (Kansas IDDRC) , and
   VA Merit Review 1I01BX002567 (JPT) .
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NR 89
TC 7
Z9 9
U1 0
U2 5
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4522
EI 1873-7544
J9 NEUROSCIENCE
JI Neuroscience
PD AUG 1
PY 2021
VL 468
BP 53
EP 67
DI 10.1016/j.neuroscience.2021.06.001
EA JUN 2021
PG 15
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA TP3IR
UT WOS:000677487600005
PM 34107347
OA Green Accepted, Green Submitted
DA 2025-06-11
ER

PT J
AU Fan, MQ
   Choi, YJ
   Tang, YJ
   Mun, S
   Yang, HP
   Kim, EK
AF Fan, Meiqi
   Choi, Young-Jin
   Tang, Yujiao
   Mun, Sung
   Yang, Hyun Pil
   Kim, Eun-Kyung
TI Efficacy and Mechanism of Polymerized Anthocyanin from Grape-Skin
   Extract on High-Fat-Diet-Induced Nonalcoholic Fatty Liver Disease
SO NUTRIENTS
LA English
DT Article
DE polymerized anthocyanin; nonalcoholic fatty liver disease; fat
   accumulation
ID HEPATIC STEATOSIS; METABOLIC SYNDROME; PPAR-GAMMA; ADIPOCYTE
   DIFFERENTIATION; OXIDATIVE STRESS; LIPID-METABOLISM; STEATOHEPATITIS;
   FIBROSIS; PATHOGENESIS; INFLAMMATION
AB We investigated the therapeutic potential of polymerized anthocyanin (PA) on a nonalcoholic fatty liver disease (NAFLD) model in mice. C57BL/6 mice were fed a high-fat diet (HFD) for 8 weeks to establish the NAFLD mouse model and randomly divided into four groups: control diet (con), NAFLD mice treated with saline (NAFLD), NAFLD mice treated with PA (PA), and NAFLD mice treated with orlistat (Orlistat) for four weeks. Mice were euthanized at the end of the four weeks. Total cholesterol (TC) and triglyceride (TG) levels were estimated, and pathological changes in the liver, white adipose tissue, and signaling pathways related to lipid metabolism were evaluated. Results revealed that the body, liver, and white fat weight of the NAFLD group was significantly increased compared to that of the con group, while that of the PA group showed significant reduction. NAFLD led to an increase in blood lipids in mice (except for HDL). Conversely, PA effectively reduced TC and LDL-C. Compared to the control group, the degree of steatosis in the mice of PA group was decreased. Moreover, PA also regulated the NAFLD signaling pathway. In agreement with improved lipid deposition, PA supplementation inhibited the activation of inflammatory pathways, depressing oxidative stress through increased antioxidant levels, and increasing beta-oxidation to inhibit mitochondrial dysfunction. Taken together, our results demonstrate that PA can improve the liver function of NAFLD mice, regulating blood lipids, reducing liver-fat accumulation, and regulating lipid metabolism.
C1 [Fan, Meiqi; Choi, Young-Jin; Tang, Yujiao; Kim, Eun-Kyung] Konkuk Univ, Coll Biomed & Hlth Sci, Div Food Biosci, Chungju 27478, South Korea.
   [Tang, Yujiao] Changchun Univ Sci & Technol, Changchun 130600, Jilin, Peoples R China.
   [Mun, Sung] Gyeongnam Agr Res & Extens Serv, Jinju 52733, Peoples R China.
   [Yang, Hyun Pil] Kitto Life Co Ltd, Tech R&D Ctr, Pyeongtacek 17749, Peoples R China.
C3 Konkuk University; Changchun University of Science & Technology
RP Kim, EK (corresponding author), Konkuk Univ, Coll Biomed & Hlth Sci, Div Food Biosci, Chungju 27478, South Korea.
EM fanmeiqi@kku.ac.kr; choijang11@kku.ac.kr; yuanxi00@126.com;
   smbae@korea.kr; yanghp0419@naver.com; eunkyungkim@kku.ac.kr
RI 唐, 玉娇/KBQ-5971-2024; fan, meiqi/JNZ-5367-2023
OI fan, meiqi/0000-0003-4343-9462; Kim, Eun-Kyung/0000-0002-4832-6427;
   Choi, Young-Jin/0000-0002-8466-4132
FU Basic Science Research Program through the National Research Foundation
   of Korea (NRF) - Ministry of Education, Science, and Technology
   [NRF-2017R1D1A1B03036247]; Ministry of Education; National Research
   Foundation of Korea; Korea Institute of Planning and Evaluation for
   Technology in Food, Agriculture, Forestry, and Fisheries (IPET) through
   the Agri-Bio Industry Technology Development Program - Ministry of
   Agriculture, Food, and Rural Affairs (MAFRA) [316027-5]
FX This work was supported by the Basic Science Research Program through
   the National Research Foundation of Korea (NRF), funded by the Ministry
   of Education, Science, and Technology (NRF-2017R1D1A1B03036247 to E.-K.
   Kim), results of a study on the "Leaders in Industry-University
   Cooperation+" project, supported by the Ministry of Education and
   National Research Foundation of Korea (LINC + to E.-K. Kim) and the
   Korea Institute of Planning and Evaluation for Technology in Food,
   Agriculture, Forestry, and Fisheries (IPET) through the Agri-Bio
   Industry Technology Development Program (316027-5) funded by the
   Ministry of Agriculture, Food, and Rural Affairs (MAFRA to E.-K. Kim).
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NR 74
TC 37
Z9 38
U1 3
U2 38
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD NOV
PY 2019
VL 11
IS 11
AR 2586
DI 10.3390/nu11112586
PG 19
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA JV3OC
UT WOS:000502274600037
PM 31717842
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Siddiqui, NY
   Helfand, BT
   Andreev, VP
   Kowalski, JT
   Bradley, MS
   Lai, HH
   Berger, MB
   Mueller, MG
   Bickhaus, JA
   Packiam, VT
   Fenner, D
   Gillispie, BW
   Kirkali, Z
AF Siddiqui, Nazema Y.
   Helfand, Brian T.
   Andreev, Victor P.
   Kowalski, Joseph T.
   Bradley, Megan S.
   Lai, H. Henry
   Berger, Mitchell B.
   Mueller, Margaret G.
   Bickhaus, Jennifer A.
   Packiam, Vignesh T.
   Fenner, Dee
   Gillispie, Brenda W.
   Kirkali, Ziya
CA Symptoms Lower Urinary Tract Dys
TI Biomarkers Implicated in Lower Urinary Tract Symptoms: Systematic Review
   and Pathway Analyses
SO JOURNAL OF UROLOGY
LA English
DT Review
DE urinary bladder; overactive; lower urinary tract symptoms; nocturia;
   urinary incontinence; stress; biomarkers
ID C-REACTIVE PROTEIN; GROWTH-FACTOR LEVELS; OVERACTIVE BLADDER; METABOLIC
   SYNDROME; CELL-FUNCTION; WOMEN; INCONTINENCE; ASSOCIATION; HEALTH; RISK
AB Purpose: Lower urinary tract symptoms are prevalent and burdensome, yet methods to enhance diagnosis and appropriately guide therapies are lacking. We systematically reviewed the literature for human studies of biomarkers associated with lower urinary tract symptoms.
   Materials and Methods: PubMed (R), EMBASE (R) and Web of Science (R) were searched from inception to February 13, 2018. Articles were included if they were in English, performed in benign urological populations without neurological disorders or interstitial cystitis/bladder pain syndrome, and assessed a biomarker's association with or ability to predict specific lower urinary tract symptoms or urological conditions. Bioinformatic pathway analyses were conducted to determine whether individual biomarkers associated with symptoms are present in unifying pathways.
   Results: Of 6,150 citations identified 125 met the inclusion criteria. Most studies (93.6%) assessed biomarkers at 1 time point and were cross-sectional in nature. Few studies adjusted for potentially confounding clinical variables or assessed biomarkers in an individual over time. No individual biomarkers are currently validated as diagnostic tools for lower urinary tract symptoms. Compared to controls, pathway analyses identified multiple immune response pathways that were enriched in overactive bladder syndrome and cell migration/cytoskeleton remodeling pathways that were enriched in female stress incontinence.
   Conclusions: Major deficiencies in the existing biomarker literature include poor reproducibility of laboratory data, unclear classification of patients with lower urinary tract symptoms and lack of adjustment for clinical covariates. Despite these limitations we identified multiple putative pathways in which panels of biological markers need further research.
C1 [Siddiqui, Nazema Y.; Bickhaus, Jennifer A.] Duke Univ, Dept Obstet & Gynecol, Div Urogynecol & Reconstruct Surg, DUMC 3192, Durham, NC 27707 USA.
   [Helfand, Brian T.] NorthShore, Glenview, IL USA.
   [Mueller, Margaret G.] Northwestern Univ, Feinberg Sch Med, Chicago, IL 60611 USA.
   [Berger, Mitchell B.; Fenner, Dee; Gillispie, Brenda W.] Univ Michigan, Ann Arbor, MI 48109 USA.
   [Andreev, Victor P.; Berger, Mitchell B.; Fenner, Dee; Gillispie, Brenda W.] Arbor Res Collaborat Hlth VPA, Ann Arbor, MI USA.
   [Kowalski, Joseph T.] Univ Iowa, Dept Obstet & Gynecol, Carver Coll Med, Iowa City, IA 52242 USA.
   [Bradley, Megan S.] Univ Pittsburgh, Magee Womens Hosp, Dept Obstet Gynecol & Reprod Sci, Div Urogynecol & Pelv Reconstruct Surg,UPMC, Pittsburgh, PA 15213 USA.
   [Lai, H. Henry] Washington Univ, Sch Med, Dept Surg, St Louis, MO 63110 USA.
   [Lai, H. Henry] Washington Univ, Sch Med, Dept Anesthesiol, St Louis, MO 63110 USA.
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   [Kirkali, Ziya] NIDDK, Bethesda, MD 20892 USA.
C3 Duke University; NorthShore University Health System; Northwestern
   University; Feinberg School of Medicine; University of Michigan System;
   University of Michigan; University of Iowa; Pennsylvania Commonwealth
   System of Higher Education (PCSHE); University of Pittsburgh; Washington
   University (WUSTL); Washington University (WUSTL); Mayo Clinic; National
   Institutes of Health (NIH) - USA; NIH National Institute of Diabetes &
   Digestive & Kidney Diseases (NIDDK)
RP Siddiqui, NY (corresponding author), Duke Univ, Dept Obstet & Gynecol, Div Urogynecol & Reconstruct Surg, DUMC 3192, Durham, NC 27707 USA.
EM nazema.siddiqui@duke.edu
RI Bradley, Megan/ABE-8131-2021; Kowalski, Joseph/JEP-4419-2023; Andreev,
   Victor/R-8241-2016; Kirkali, Ziya/AAC-1629-2021
OI Packiam, Vignesh/0000-0001-8397-7797; Kirkali, Ziya/0000-0002-2918-4347
FU National Institute of Diabetes and Digestive and Kidney Diseases
   [DK097780, DK097772, DK097779, DK099932, DK100011, DK100017, DK097776,
   DK099879, K23-DK110417]; National Institutes of Health National Center
   for Advancing Translational Sciences [UL1TR001422]; National Institute
   of Diabetes and Digestive and Kidney Diseases [U01DK099932] Funding
   Source: NIH RePORTER
FX Supported by the National Institute of Diabetes and Digestive and Kidney
   Diseases through cooperative agreements (Grants DK097780, DK097772,
   DK097779, DK099932, DK100011, DK100017, DK097776, DK099879).r Research
   at Northwestern University was supported by the National Institutes of
   Health National Center for Advancing Translational Sciences, Grant
   Number UL1TR001422. The content is solely the responsibility of the
   authors and does not necessarily represent the official views of the
   National Institutes of Health.r Supported by Grant K23-DK110417 from the
   National Institute of Diabetes and Digestive and Kidney Diseases.
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NR 44
TC 33
Z9 35
U1 1
U2 7
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0022-5347
EI 1527-3792
J9 J UROLOGY
JI J. Urol.
PD NOV
PY 2019
VL 202
IS 5
BP 882
EP 891
DI 10.1097/JU.0000000000000257
PG 10
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA JN5FM
UT WOS:000496924200056
PM 30925127
OA Green Accepted
DA 2025-06-11
ER

PT J
AU García-Arroyo, FE
   Monroy-Sánchez, F
   Muñoz-Jiménez, I
   Gonzaga, G
   Andrés-Hernando, A
   Zazueta, C
   Juárez-Rojas, JG
   Lanaspa, MA
   Johnson, RJ
   Sánchez-Lozada, LG
AF Garcia-Arroyo, Fernando E.
   Monroy-Sanchez, Fabiola
   Munoz-Jimenez, Itzel
   Gonzaga, Guillermo
   Andres-Hernando, Ana
   Zazueta, Cecilia
   Gabriel Juarez-Rojas, J.
   Lanaspa, Miguel A.
   Johnson, Richard J.
   Gabriela Sanchez-Lozada, L.
TI Allopurinol Prevents the Lipogenic Response Induced by an Acute Oral
   Fructose Challenge in Short-Term Fructose Fed Rats
SO BIOMOLECULES
LA English
DT Article
DE hepatic steatosis; mitochondria; mitochondrial complex 1
ID FATTY LIVER-DISEASE; URIC-ACID; HEPATIC STEATOSIS; NONALCOHOLIC
   STEATOHEPATITIS; INSULIN-RESISTANCE; METABOLIC SYNDROME; POTENTIAL-ROLE;
   HOMEOSTASIS; OBESITY; STRESS
AB We investigated whether short term high fructose intake may induce early hepatic dysfunction in rats and to test whether allopurinol treatment may have beneficial effects. Twenty male Sprague-Dawley rats received 20% fructose in drinking water (10 treated with allopurinol and 10 received vehicle) and 10 control rats received tap water. After 14 days, the hepatic response to an acute fructose load was evaluated, and in fasted animals, respirometry studies in freshly isolated mitochondria were performed. In fasting rats, we did not find differences in systemic or hepatic uric acid and triglyceride concentrations among the groups, but mitochondrial respiratory control rate was significantly decreased by high fructose feeding and correlated with a reduced expression of Complex I, as well as decreased aconitase-2 activity. On the other hand, in fructose fed rats, an acute fructose load increased systemic and hepatic uric acid, triglycerides and oxidative stress. Fructose feeding was also associated with fructokinase and xanthine oxidase overexpression and increased liver de novo lipogenesis program (fatty acid synthase (FAS) and cell death-inducing DFFA-like effector C (CIDEC) overexpression, ATP citrate lyase (ACL) and acetyl coA carboxylase (ACC) overactivity and decreased AMP-activated protein kinase (AMPk) and endothelial nitric oxide synthase (eNOS) activation). Allopurinol treatment prevented hepatic and systemic alterations. These data suggest that early treatment with xanthine oxidase inhibitors might provide a therapeutic advantage by delaying or even halting the progression of non-alcoholic fatty liver disease (NAFLD).
C1 [Garcia-Arroyo, Fernando E.; Monroy-Sanchez, Fabiola; Munoz-Jimenez, Itzel; Gonzaga, Guillermo; Gabriela Sanchez-Lozada, L.] INC Ignacio Chavez, Dept Cardio Renal Physiopathol, Mexico City 14080, DF, Mexico.
   [Andres-Hernando, Ana; Lanaspa, Miguel A.; Johnson, Richard J.] Univ Colorado, Renal Dis & Hypertens, Aurora, CO 80045 USA.
   [Zazueta, Cecilia] INC Ignacio Chavez, Dept Cardiovasc Biomed, Mexico City 14080, DF, Mexico.
   [Gabriel Juarez-Rojas, J.] INC Ignacio Chavez, Dept Endocrinol, Mexico City 14080, DF, Mexico.
C3 University of Colorado System; University of Colorado Anschutz Medical
   Campus
RP Sánchez-Lozada, LG (corresponding author), INC Ignacio Chavez, Dept Cardio Renal Physiopathol, Mexico City 14080, DF, Mexico.
EM jonibertojr@hotmail.com; fabyms@gmail.com; itzel.morrison@icloud.com;
   ggonzaga49@gmail.com; Ana.AndresHernando@cuanschutz.edu;
   czazuetam@hotmail.com; gaboyk2@gmail.com;
   Miguel.LanaspaGarcia@cuanschutz.edu; Richard.Johnson@cuanschutz.edu;
   lgsanchezlozada@gmail.com
RI Juárez-Rojas, Juan/AAM-9486-2020; Sanchez-Lozada, Laura/AAS-2104-2021;
   Zazueta, Cecilia/AAM-7502-2021; Lanaspa, Miguel/AAO-4971-2020
OI Juarez-Rojas, Juan Gabriel/0000-0001-8864-2304; Garcia Arroyo, Fernando
   Enrique/0000-0003-1545-9765; Zazueta, Cecilia/0000-0003-1068-316X;
   Andres-Hernando, Ana/0000-0002-0676-0188; Sanchez-Lozada,
   Laura-Gabriela/0000-0003-0348-9617
FU Fondos de Gasto Directo autorizado a la Subdireccion de Investigacion
   Basica; F.E.G.A; CONACyT, Mexico
FX This work was funded by Fondos de Gasto Directo autorizado a la
   Subdireccion de Investigacion Basica. Instituto Nacional de Cardiologia
   Ignacio Chavez. F.E.G.A and I.M.J are recipients of fellowships granted
   by CONACyT, Mexico.
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NR 40
TC 13
Z9 15
U1 0
U2 5
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2218-273X
J9 BIOMOLECULES
JI Biomolecules
PD OCT
PY 2019
VL 9
IS 10
AR 601
DI 10.3390/biom9100601
PG 14
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA JO6ZX
UT WOS:000497726800093
PM 31614639
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Zhang, YN
   Yamamoto, T
   Hisatome, I
   Li, YF
   Cheng, WJ
   Sun, N
   Cai, BZ
   Huang, TL
   Zhu, YZ
   Li, Z
   Jing, XB
   Zhou, R
   Cheng, JD
AF Zhang, Yongneng
   Yamamoto, Tetsuya
   Hisatome, Ichiro
   Li, Youfeng
   Cheng, Weijie
   Sun, Ning
   Cai, Bozhi
   Huang, Tianliang
   Zhu, Yuzhang
   Li, Zhi
   Jing, Xubin
   Zhou, Rui
   Cheng, Jidong
TI Uric acid induces oxidative stress and growth inhibition by activating
   adenosine monophosphate-activated protein kinase and extracellular
   signal-regulated kinase signal pathways in pancreatic β cells
SO MOLECULAR AND CELLULAR ENDOCRINOLOGY
LA English
DT Article
DE Hyperuricemia; Pancreatic beta-cell; Oxidative stress; AMPK; ERK
ID SMOOTH-MUSCLE-CELLS; STIMULATED INSULIN-SECRETION; METABOLIC SYNDROME;
   NADPH OXIDASE; URATE TRANSPORTER; GLUCOSE; HYPERURICEMIA; PROLIFERATION;
   EXPRESSION; SYSTEM
AB Hyperuricaemia is a disorder of purine metabolism, and is strongly associated with insulin resistance and abnormal glucose metabolism. As the producer of insulin, pancreatic beta cells might be affected by elevated serum uric acid levels and contribute to the disregulated glucose metabolism. In this study, we investigated the effect of high uric acid on rat pancreatic beta cell function. Under high uric acid condition, proliferation of pancreatic beta cells was inhibited, production of reactive oxygen species increased, and glucose stimulated insulin secretion was also compromised. Further examination on signal transduction pathways revealed that uric acid-induced ROS is involved in the activation of adenosine monophosphate-activated protein kinase (AMPK), and extracellular signal-regulated kinase (ERK). Pharmacological inhibition of ERK activation rescued beta cells from growth inhibition. More importantly, activation of ERK induced by uric acid is significantly diminished by AMPK inhibitor, indicating ERK as a downstream target of AMPK in response to high uric acid condition. We also investigated the transportation channel for uric acid into pancreatic beta cells. While major urate transporter URAT1 is not expressed in beta cells, organic anion transporter (OAT) inhibitor successfully blocked the activation of ERK by uric acid. Our data indicate that high uric acid levels induce oxidative damage and inhibit growth of rat pancreatic beta cells by activating the AMPK and ERK signal pathways. Hyperuricemia may contribute to abnormal glucose metabolism by causing oxidative damage and function inhibition of pancreatic beta cells. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
C1 [Zhang, Yongneng; Li, Youfeng; Cheng, Weijie; Sun, Ning; Cai, Bozhi; Huang, Tianliang; Zhu, Yuzhang; Li, Zhi; Jing, Xubin; Zhou, Rui; Cheng, Jidong] Shantou Univ, Coll Med, Affiliated Hosp 1, Dept Internal Med, Shantou 515031, Guangdong, Peoples R China.
   [Yamamoto, Tetsuya] Hyogo Coll Med, Dept Internal Med, Nishinomiya, Hyogo 6638501, Japan.
   [Hisatome, Ichiro] Tottori Univ, Grad Sch Med Sci, Inst Regenerat Med & Biofunct, Div Regenerat Med & Therapeut, Yonago, Tottori, Japan.
C3 Shantou University; Hyogo Medical University; Tottori University
RP Cheng, JD (corresponding author), Shantou Univ, Coll Med, Affiliated Hosp 1, Dept Internal Med, Shantou 515031, Guangdong, Peoples R China.
EM jidongcheng36@hotmail.com
RI Zhu, Yuzhang/AIC-6505-2022; li, yali/K-6999-2013
FU National Natural Science Foundation of China [81070673, 81172263];
   Special Foundation of Guangdong Province College Talent Introduction
   [10027425]; Scientific Research Foundation for the Returned Overseas
   Chinese Scholars, State Education Ministry [20111568]
FX This work was supported by grants from the National Natural Science
   Foundation of China (81070673 and 81172263), the Special Foundation of
   Guangdong Province College Talent Introduction (10027425), and the
   Project Sponsored by the Scientific Research Foundation for the Returned
   Overseas Chinese Scholars, State Education Ministry (20111568).
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NR 33
TC 105
Z9 114
U1 2
U2 50
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0303-7207
J9 MOL CELL ENDOCRINOL
JI Mol. Cell. Endocrinol.
PD AUG 15
PY 2013
VL 375
IS 1-2
BP 89
EP 96
DI 10.1016/j.mce.2013.04.027
PG 8
WC Cell Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Endocrinology & Metabolism
GA 186OS
UT WOS:000322054600011
PM 23707617
DA 2025-06-11
ER

PT J
AU Nobile, V
   Pisati, M
   Cestone, E
   Insolia, V
   Zaccaria, V
   Malfa, GA
AF Nobile, Vincenzo
   Pisati, Marta
   Cestone, Enza
   Insolia, Violetta
   Zaccaria, Vincenzo
   Malfa, Giuseppe Antonio
TI Antioxidant Efficacy of a Standardized Red Orange (Citrus
   sinensis (L.) Osbeck) Extract in Elderly Subjects: A Randomized,
   Double Blind, Controlled Study
SO NUTRIENTS
LA English
DT Article
DE plant secondary metabolites; oxidative stress; aging; red orange
   extract; food supplement; menopause
ID HORMONE-THERAPY; METABOLIC SYNDROME; OXIDATIVE STRESS; FLAVONOIDS;
   SUPPLEMENTATION; MECHANISMS; SYMPTOMS; DAMAGE
AB The world population is rapidly aging. This should cause us to reflect on the need to develop a new nutritional approach to mitigate the accumulation of reactive oxygen species (ROS)-induced damage. A randomized, double blind, controlled study was carried out on 60 elderly male and female subjects. Product efficacy was measured before and after 2 and 8 weeks of product intake. The reduced (GSH) and oxidized (GSSG) glutathione concentrations in the erythrocytes and the reactive oxygen metabolites (d-ROMs) hematic concentration were measured to assess the antioxidant efficacy. The tumor necrosis factor-alpha (TNF-alpha) levels in the serum were measured to assess the anti-inflammatory effectiveness. The wellbeing was assessed by Short Form Health Survey (SF-36) questionnaire (male) and by Menopause Rating Scale (MRS) (female). Blood, urine analysis and electrocardiography (ECG) were carried out to assess the product's safety. The results showed that GSH/GSSG ratio increased by 22.4% and 89.0% after 2 and 8 weeks of product intake. Serum TNF-alpha levels decreased by 2.5% after 8 weeks of product intake. The SF-36 QoL and the MRS questionnaire outputs indicate, preliminarily, a positive effect of the extract intake in ameliorating the wellbeing of both male and female subjects. The product was well-tolerated. Our findings suggest that the test product has antioxidant and anti-inflammatory efficacy and has a positive effect on the wellbeing of elderly female and male subjects.
C1 [Nobile, Vincenzo; Pisati, Marta; Cestone, Enza] Complife Italia Srl, R&D Dept, I-27028 San Martino Siccomario, PV, Italy.
   [Insolia, Violetta] Alma Mater Europea, Koper 6000, Slovenia.
   [Zaccaria, Vincenzo] Bionap Srl, R&D Dept, I-95032 Belpasso, CT, Italy.
   [Malfa, Giuseppe Antonio] Univ Catania, Dept Drug & Hlth Sci, Viale A Doria, I-95125 Catania, CT, Italy.
   [Malfa, Giuseppe Antonio] Univ Catania, CERNUT Res Ctr Nutraceut & Hlth Prod, Viale A Doria, I-95125 Catania, CT, Italy.
C3 University of Catania; University of Catania
RP Nobile, V (corresponding author), Complife Italia Srl, R&D Dept, I-27028 San Martino Siccomario, PV, Italy.; Zaccaria, V (corresponding author), Bionap Srl, R&D Dept, I-95032 Belpasso, CT, Italy.
EM vincenzo.nobile@complifegroup.com; v.zaccaria@bionap.com
RI ; Malfa, Giuseppe/AAG-4234-2020
OI Zaccaria, Vincenzo/0000-0002-8143-2838; Malfa,
   Giuseppe/0000-0002-6733-0587; Nobile, Vincenzo/0000-0001-9147-302X
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NR 42
TC 5
Z9 5
U1 0
U2 9
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD OCT
PY 2022
VL 14
IS 20
AR 4235
DI 10.3390/nu14204235
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 5Q0WD
UT WOS:000873560000001
PM 36296919
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Zafrilla, P
   Masoodi, H
   Cerda, B
   García-Viguera, C
   Villaño, D
AF Zafrilla, Pilar
   Masoodi, Hedyeh
   Cerda, Begona
   Garcia-Viguera, Cristina
   Villano, Debora
TI Biological effects of stevia, sucralose and sucrose in citrus-maqui
   juices on overweight subjects
SO FOOD & FUNCTION
LA English
DT Article
ID METABOLIC SYNDROME; RISK-FACTORS; PATHOGENIC INTERACTION; ANTIOXIDANT
   CAPACITY; INSULIN-RESISTANCE; OXIDATIVE STRESS; HDL-CHOLESTEROL;
   OXIDIZED LDL; FRUIT JUICES; RED WINE
AB Background: In the last few years there has been emerging interest in substituting added sugars from juices with other sweeteners to make them healthier. But their long-term effects have been poorly evaluated. The aim of this study is to evaluate the effect of the addition of stevia, sucralose and sucrose (control) to maqui-citrus beverages on antioxidant and inflammatory status. Methods: a 3-arm parallel, randomized and triple blind clinical trial was performed in overweight subjects (n = 138), who consumed the test beverage (330 mL day(-1)) for 60 days. The following markers were determined: antioxidant status (ORAC, homocysteine, and oxidized LDL), safety parameters (ALP, AST, ALT, and total bilirubin), lipid profile (total cholesterol, LDL-cholesterol, HDL-cholesterol, and triglycerides) and inflammatory biomarkers (IL-6, TNF-alpha, and IL-10). Results: The homocysteine levels significantly increased after consumption of sucralose (27%, p = 0.001) and sucrose (40%, p = 0.006). A significant increase in the IL-10 concentration after consumption of the stevia sweetened beverage, and in ORAC values (21%) in subjects with lower basal antioxidant status were observed. The HDL and total cholesterol levels significantly increased after consumption of sucralose (p = 0.039) and sucrose (p = 0.001), respectively. No changes in triglycerides, LDL or oxidized LDL were observed. Conclusions: Oxidative stress and an inflammatory response were observed after consumption of these sweetened beverages, with the exception of stevia, which produced an anti-inflammatory response. The possible antioxidative effects of this polyphenol-rich beverage may only benefit those individuals with poorer antioxidant status. Many randomized controlled trials at normal levels of consumption using commonly consumed sweeteners are necessary to clarify their roles in health.
C1 [Zafrilla, Pilar; Masoodi, Hedyeh; Cerda, Begona; Villano, Debora] Catholic Univ San Antonio UCAM, Dept Pharm, Fac Hlth Sci, Campus Jeronimos, Murcia 30107, Spain.
   [Garcia-Viguera, Cristina] CSIC, CEBAS, Dept Food Sci & Technol, Phytochem & Hlth Foods Lab, Campus Univ Espinardo 25, Murcia 30100, Spain.
C3 Universidad Catolica de Murcia; Consejo Superior de Investigaciones
   Cientificas (CSIC); CSIC - Centro de Edafologia y Biologia Aplicada del
   Segura (CEBAS)
RP Cerda, B (corresponding author), Catholic Univ San Antonio UCAM, Dept Pharm, Fac Hlth Sci, Campus Jeronimos, Murcia 30107, Spain.
EM hed_ms@yahoo.com
RI Cerdá, Begoña/AAC-1788-2022; Zafrilla, Pilar/JAN-5983-2023; Villano
   Valencia, Debora/F-1022-2012; Begona, Cerda/K-5993-2014; GARCIA-VIGUERA,
   CRISTINA/B-2153-2012
OI Villano Valencia, Debora/0000-0002-8162-8857; Begona,
   Cerda/0000-0003-0385-1145; GARCIA-VIGUERA, CRISTINA/0000-0002-4751-3917;
   ZAFRILLA, PILAR/0000-0002-1463-7120
FU Comision Interministerial de Ciencia y Tecnologia (CICYT)
FX The authors acknowledge the financial support from Comision
   Interministerial de Ciencia y Tecnologia (CICYT).
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NR 56
TC 13
Z9 14
U1 3
U2 25
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PD SEP 21
PY 2021
VL 12
IS 18
BP 8535
EP 8543
DI 10.1039/d1fo01160j
EA JUL 2021
PG 9
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA US9CL
UT WOS:000678732100001
PM 34323244
DA 2025-06-11
ER

PT J
AU Rathod, P
   Yadav, RP
AF Rathod, Priyanka
   Yadav, Raman P.
TI Anti-diabesity potential of various multifunctional natural molecules
SO JOURNAL OF HERBAL MEDICINE
LA English
DT Review
DE Multifunctional molecule; Natural molecule; Anti-diabesity; Oxidative
   stress; Lipase inhibitor; Alpha glucosidase inhibitor
ID GREEN TEA POLYPHENOL; PANCREATIC LIPASE; ALPHA-GLUCOSIDASE; DIETARY
   POLYPHENOLS; METABOLIC SYNDROME; OXIDATIVE STRESS; IN-VITRO;
   INSULIN-RESISTANCE; DIABETES-MELLITUS; CITRUS FLAVONOIDS
AB Diabesity represents a classic example of a multifactorial disease. The current strategy for the treatment of diabesity is the inhibition of enzymes involved in carbohydrate and lipid metabolism using various drugs. Side effects caused by the drugs available in the market for the treatment of diabesity have necessitated the discovery and development of new novel drugs. In recent years natural molecules have gained importance in the management of multifactorial disease. These molecules are multitargeted in nature and can be useful in the management of diabesity. Some natural molecules are able to regulate gene expression involved in metabolic pathways like adiponectin gene expression, peroxisome proliferator-activated receptor gamma. Apart from gene regulation they are able to inhibit the metabolic enzymes like lipases, amylases and glucosidases. Plants present good sources of natural multifunctional molecules. A number of natural molecules including flavonoids have been reported for multifunctionality. The structural configuration of flavonoids affects the enzymatic activity of lipases and glucosidases which can be useful for designing and development of new drugs for targeting diabesity. The consumption of food in the form of medicine can add a new dimension to the existing drug market. The further acceptance of natural molecules will need to be supported by large clinical studies including studies for toxicity and bioavailability. The present review will provide insight into the anti-diabesity potential of multifunctional natural molecules and will also explain some of the natural molecules in terms of biodistribution and safety. Data from clinical studies of a few such natural molecules is also presented.
C1 [Rathod, Priyanka; Yadav, Raman P.] MGM Inst Hlth Sci, MGM Sch Biomed Sci, Dept Med Biotechnol, Sect 1, Navi Mumbai 410209, Maharashtra, India.
   [Rathod, Priyanka; Yadav, Raman P.] MGM Inst Hlth Sci, MGM Med Coll & Hosp, MGM Cent Res Lab, MGMIHS OM Res Ctr,Sect 1, Navi Mumbai 410209, Maharashtra, India.
RP Yadav, RP (corresponding author), MGM Inst Hlth Sci, MGM Med Coll & Hosp, MGM Cent Res Lab, MGMIHS OM Res Ctr,Sect 1, Navi Mumbai 410209, Maharashtra, India.
EM ramanpyadav@gmail.com
OI Rathod, Priyanka/0000-0001-5011-4151
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NR 139
TC 7
Z9 7
U1 0
U2 13
PU ELSEVIER GMBH
PI MUNICH
PA HACKERBRUCKE 6, 80335 MUNICH, GERMANY
SN 2210-8033
EI 2210-8041
J9 J HERB MED
JI J. Herb. Med.
PD JUN
PY 2021
VL 27
AR 100430
DI 10.1016/j.hermed.2021.100430
EA MAR 2021
PG 11
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA RO9VY
UT WOS:000641387900002
DA 2025-06-11
ER

PT J
AU Somabhai, CA
   Raghuvanshi, R
   Nareshkumar, G
AF Somabhai, Chaudhari Archana
   Raghuvanshi, Ruma
   Nareshkumar, G.
TI Genetically Engineered Escherichia coli Nissle 1917 Synbiotics
   Reduce Metabolic Effects Induced by Chronic Consumption of Dietary
   Fructose
SO PLOS ONE
LA English
DT Article
ID FATTY-ACID SYNTHESIS; PYRROLOQUINOLINE-QUINONE; OXIDATIVE STRESS; GUT
   MICROBIOTA; HYPERLIPIDEMIA; PREBIOTICS; PROTECTS; SYSTEM; DAMAGE; RATS
AB Aims
   To assess protective efficacy of genetically modified Escherichia coli Nissle 1917 (EcN) on metabolic effects induced by chronic consumption of dietary fructose.
   Materials and Methods
   EcN was genetically modified with fructose dehydrogenase (fdh) gene for conversion of fructose to 5-keto-D-fructose and mannitol-2-dehydrogenase (mt/K) gene for conversion to mannitol, a prebiotic. Charles foster rats weighing 150-200 g were fed with 20% fructose in drinking water for two months. Probiotic treatment of EcN (pqq), EcN (pqq-glf-mt/K), EcN (pqq-fdh) was given once per week 109 cells for two months. Furthermore, blood and liver parameters for oxidative stress, dyslipidemia and hyperglycemia were estimated. Fecal samples were collected to determine the production of short chain fatty acids and pyrroloquinoline quinone (PQQ) production.
   Results
   EcN (pqq-glf-mtIK), EcN (pqq-fdh) transformants were confirmed by restriction digestion and functionality was checked by PQQ estimation and HPLC analysis. There was significant increase in body weight, serum glucose, liver injury markers, lipid profile in serum and liver, and decrease in antioxidant enzyme activity in high-fructose-fed rats. However the rats treated with EcN (pqq-glf-mt/K) and EcN (pqq-fdh) showed significant reduction in lipid peroxidation along with increase in serum and hepatic antioxidant enzyme activities. Restoration of liver injury marker enzymes was also seen. Increase in short chain fatty acids (SCFA) demonstrated the prebiotic effects of mannitol and gluconic acid.
   Conclusions
   Our study demonstrated the effectiveness of probiotic EcN producing PQQ and fructose metabolizing enzymes against the fructose induced hepatic steatosis suggesting that its potential for use in treating fructose induced metabolic syndrome.
C1 [Somabhai, Chaudhari Archana; Raghuvanshi, Ruma; Nareshkumar, G.] Maharaja Sayajirao Univ Baroda, Dept Biochem, Fac Sci, Vadodara 390002, Gujarat, India.
C3 Maharaja Sayajirao University Baroda
RP Nareshkumar, G (corresponding author), Maharaja Sayajirao Univ Baroda, Dept Biochem, Fac Sci, Vadodara 390002, Gujarat, India.
EM gnaresh_k@yahoo.co.in
RI Gattupalli, Naresh/AAF-5987-2020
FU DBT and ICMR, New Delhi, India
FX Chaudhari Archana Somabhai and Ruma Raghuvanshi are supported by Senior
   Research Fellowship of DBT and ICMR, New Delhi, India respectively. We
   thank Dr. Rer. Nat. Ulrich Sonnenborn, Ardeypharm GmbH, Loerfeldstrabe
   20, Herdecke (Germany) for providing Escherichia coli Nissle 1917, and
   the DBT-ILSPARE Program for carrying out real-time PCR and HPLC
   experiments. Chaudhari Archana Somabhai and Ruma Raghuvanshi are
   supported by Senior Research Fellowship of DBT and ICMR, New Delhi,
   India respectively.
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NR 39
TC 22
Z9 31
U1 0
U2 24
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD OCT 19
PY 2016
VL 11
IS 10
AR e0164860
DI 10.1371/journal.pone.0164860
PG 15
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA DZ9NW
UT WOS:000386204000061
PM 27760187
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Fang, B
   Zhang, M
   Ren, FZ
   Zhou, XD
AF Fang, Bing
   Zhang, Ming
   Ren, Fa Zheng
   Zhou, Xiao Dan
TI Lifelong diet including common unsaturated fatty acids extends the
   lifespan and affects oxidation in Caenorhabditis elegans
   consistently with hormesis model
SO EUROPEAN JOURNAL OF LIPID SCIENCE AND TECHNOLOGY
LA English
DT Article
DE Caloric restriction; Hormesis; Linoleic acid; Linolenic acid; Oleic acid
ID CARDIOVASCULAR-DISEASE; SUPEROXIDE-DISMUTASE; CALORIC RESTRICTION;
   METABOLIC SYNDROME; C-ELEGANS; LONGEVITY; STRESS; MICE; GENETICS;
   SURVIVAL
AB Diets abundant in unsaturated fatty acids (UFAs) help to support a longer and healthier life. We evaluated effects of dietary oleic acid (OA), linoleic acid (LnA), and linolenic acid (ALA) on lifespan and physical activities of Caenorhabditis elegans (C. elegans). Supplementation at doses per plate of 0.5 mg OA, 0.1 mg LnA, or 0.5 mg ALA extended the lifespan of C. elegans by 10.49, 14.17, or 8.47%, respectively (p < 0.05). At these doses, LnA and ALA significantly inhibited growth, pharyngeal pumping, reproduction, and respiration (p < 0.05), while OA did not influence these physiological activities (p > 0.05). Furthermore, OA significantly increased superoxide dismutase, catalase, and glutathione peroxidase activities. Based on results obtained with wild-type N2, eat-2, and sod-2-mutated C. elegans, OA extended C. elegans lifespan through a hormesis mechanism by activating antioxidant enzymes. In contrast, LnA and ALA acted via a caloric restriction mechanism. Consistent with calorie restriction being a type of stress, however, lifespan was shortened as LnA and ALA doses were further increased. Therefore, the effects of all three fatty acids might be regarded as being consistent with a classic hormesis effect.
   Practical applications: Oleic acid, linoleic acid, and linolenic acid are the three most common unsaturated fatty acids in vegetable oils. The beneficial effects of oleic acid, linoleic acid, and linolenic acid supplementation on lifespan, normal physiological activities, and oxidation in our study support consumers choosing vegetable oils in their diets.
C1 [Fang, Bing] Acad State Adm Grain, Beijing, Peoples R China.
   [Zhang, Ming] Beijing Technol & Business Univ, Sch Food Sci & Chem Engn, Beijing, Peoples R China.
   [Fang, Bing; Ren, Fa Zheng] China Agr Univ, Beijing Lab Food Qual & Safety, Beijing, Peoples R China.
   [Ren, Fa Zheng; Zhou, Xiao Dan] China Agr Univ, Key Lab Funct Dairy, Coll Food Sci & Nutr Engn, Beijing, Peoples R China.
C3 Beijing Technology & Business University; China Agricultural University;
   China Agricultural University
RP Fang, B (corresponding author), Acad State Adm Grain, Grp Lipid Chem & Proc Tech, 11 Baiwanzhuang Rd, Beijing 100037, Peoples R China.
EM Fb@chinagrain.org
OI Zhang, Ming/0000-0003-1175-4636
FU Beijing Science and Technology Project [D141100004814001]; Ministry of
   Science and Technology of the People's Republic of China [2012BAD12B08];
   Beijing Municipal Commission of Education Co-constructed Program
FX We gratefully acknowledge financial support from the Beijing Science and
   Technology Project (D141100004814001), the Ministry of Science and
   Technology of the People's Republic of China (2012BAD12B08) and the
   Beijing Municipal Commission of Education Co-constructed Program.
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NR 47
TC 7
Z9 7
U1 2
U2 47
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1438-7697
EI 1438-9312
J9 EUR J LIPID SCI TECH
JI Eur. J. Lipid Sci. Technol.
PD JUL
PY 2016
VL 118
IS 7
BP 1084
EP 1092
DI 10.1002/ejlt.201500237
PG 9
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA DR6PI
UT WOS:000380023400011
DA 2025-06-11
ER

PT J
AU D'Alessandro, ME
   Selenscig, D
   Illesca, P
   Chicco, A
   Lombardo, YB
AF Eugenia D'Alessandro, Maria
   Selenscig, Dante
   Illesca, Paola
   Chicco, Adriana
   Lombardo, Yolanda B.
TI Time course of adipose tissue dysfunction associated with antioxidant
   defense, inflammatory cytokines and oxidative stress in dyslipemic
   insulin resistant rats
SO FOOD & FUNCTION
LA English
DT Article
ID INDUCED METABOLIC SYNDROME; NECROSIS-FACTOR-ALPHA; HIGH-SUCROSE DIET;
   FISH-OIL; GLUTATHIONE PEROXIDASE; GENE-EXPRESSION; VITAMIN-E; OBESITY;
   LIVER; RICH
AB The dysfunctional adipose tissue of rats fed a sucrose-rich diet was investigated following the time course of the development of oxidative stress, changes in proinflammatory cytokines and adiponectin levels, and their relationship with insulin resistance. We analyzed the morphometric characteristics of epididymal adipocytes, de novo lipogenesis enzyme activities and cellular antioxidant defense, inflammatory mediators, adiponectin levels and insulin resistance in rats fed a sucrose-rich diet for 3, 15 or 30 weeks and compared to those fed a control diet. The results showed a depletion of antioxidant enzyme activities in the fat pads of rats fed a sucrose-rich diet, with an increase in xanthine oxidase activity and lipid peroxidation after 3, 15 and 30 weeks on the diet. Superoxide dismutase activity and the redox state of glutathione showed a significant decrease at weeks 15 and 30. This was accompanied by visceral adiposity and enhanced lipogenic enzyme activities. An increase in the plasma levels of proinflammatory markers (TNF-alpha and IL-6) was recorded only after 30 weeks on the diet. A reduction in plasma adiponectin levels accompanied the time course of deterioration of whole-body insulin sensitivity. The results suggest that lipid peroxidation, depletion of antioxidant defenses and changes in inflammatory cytokines induced by a sucrose-rich diet contribute to the dysregulation of adipose tissue and insulin resistance. Finally, these results show that the progressive deterioration of adipose tissue function, which begins in the absence of both visceral adiposity and overweight, is highly dependent on the length of time on the diet.
C1 [Eugenia D'Alessandro, Maria; Selenscig, Dante; Illesca, Paola; Chicco, Adriana; Lombardo, Yolanda B.] Univ Litoral, Sch Biochem, Dept Biochem, Santa Fe, Argentina.
C3 National University of the Littoral
RP D'Alessandro, ME (corresponding author), Univ Litoral, Sch Biochem, Dept Biochem, Santa Fe, Argentina.
EM ylombard@fbcb.unl.edu.ar
RI Illesca, Paola/IVH-6615-2023
OI Illesca, Paola/0000-0002-8491-2458; D' Alessandro, Maria
   Eugenia/0000-0001-6008-5614
FU FONCYT; CONICET; University of Litoral [PICT 0945, PIP 0105]
FX The present study was carried out with the financial support of FONCYT,
   CONICET and University of Litoral (grants PICT 0945, PIP 0105 and CAI +
   D 2012).
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NR 56
TC 31
Z9 31
U1 0
U2 5
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PY 2015
VL 6
IS 4
BP 1299
EP 1309
DI 10.1039/c4fo00903g
PG 11
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA CI1RW
UT WOS:000354522900026
PM 25765549
DA 2025-06-11
ER

PT J
AU Rogers, JM
   Ellis-Hutchings, RG
   Grey, BE
   Zucker, RM
   Norwood, J
   Grace, CE
   Gordon, CJ
   Lau, C
AF Rogers, John M.
   Ellis-Hutchings, Robert G.
   Grey, Brian E.
   Zucker, Robert M.
   Norwood, Joel, Jr.
   Grace, Curtis E.
   Gordon, Christopher J.
   Lau, Christopher
TI Elevated Blood Pressure in Offspring of Rats Exposed to Diverse
   Chemicals During Pregnancy
SO TOXICOLOGICAL SCIENCES
LA English
DT Article
DE DOHaD; fetal programming; fetal physiology; maternal toxicity; maternal
   stress
ID MATERNAL PROTEIN RESTRICTION; RENIN-ANGIOTENSIN SYSTEM;
   LOW-BIRTH-WEIGHT; INDUCED HYPERTENSION; METABOLIC SYNDROME;
   11-BETA-HYDROXYSTEROID DEHYDROGENASE; GLUCOCORTICOID-RECEPTOR;
   DEVELOPMENTAL ORIGINS; GLUCOSE-METABOLISM; ADULT DISEASE
AB Adverse intrauterine environments have been associated with increased risk of later cardiovascular disease and hypertension. In an animal model using diverse developmental toxicants, we measured blood pressure (BP), renal nephron endowment, renal glucocorticoid receptor (GR) gene expression, and serum aldosterone in offspring of pregnant Sprague Dawley rats exposed to dexamethasone (Dex), perfluorooctane sulfonate (PFOS), atrazine, perfluorononanoic acid (PFNA), arsenic, or nicotine. BP was assessed by tail cuff photoplethysmography, nephron endowment by confocal microscopy, and renal GR mRNA by qPCR. BP was also measured by telemetry, and corticosterone (CORT) was measured in resting or restrained Dex and atrazine offspring. Treated dams gained less weight during treatment in all groups except arsenic. There were chemical- and sex-specific effects on birth weight, but offspring body weights were similar by weaning. BP was higher in Dex, PFOS, atrazine, and PFNA male offspring by 710 weeks. Female offspring exhibited elevated BP at 10 weeks for PFNA and arsenic, and at 37 weeks for Dex, PFOS, and atrazine. Dex, PFOS, and atrazine offspring still exhibited elevated BP at 5265 weeks of age; others did not. Elevated BP was associated with lower nephron counts. Dex, PFOS, and atrazine offspring had elevated renal GR gene expression. Elevations in BP were also observed in Dex and atrazine offspring by radiotelemetry. Atrazine offspring exhibited enhanced CORT response to restraint. Elevated offspring BP was induced by maternal exposure to toxicants. Because all treatments affected maternal gestational weight gain, maternal stress may be a common underlying factor in these observations.
C1 [Rogers, John M.; Ellis-Hutchings, Robert G.; Grey, Brian E.; Zucker, Robert M.; Norwood, Joel, Jr.; Grace, Curtis E.; Gordon, Christopher J.; Lau, Christopher] US EPA, Tox Assessment Div, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Res Triangle Pk, NC 27711 USA.
C3 United States Environmental Protection Agency
RP Rogers, JM (corresponding author), US EPA, Tox Assessment Div, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Mail Drop B105-04, Res Triangle Pk, NC 27711 USA.
EM rogers.john@epa.gov
RI Gordon, Christopher/KVB-4813-2024; Lau, Christopher/O-1914-2013
FU Environmental Protection Agency
FX The research described in this article has been reviewed and approved
   for publication as an EPA document. Approval does not necessarily
   signify that the contents reflect the views and policies of the Agency,
   nor does mention of trade names or commercial products constitute
   endorsement or recommendation for use. All funding for this research
   came from the Environmental Protection Agency.
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NR 65
TC 50
Z9 56
U1 0
U2 42
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1096-6080
EI 1096-0929
J9 TOXICOL SCI
JI Toxicol. Sci.
PD FEB
PY 2014
VL 137
IS 2
BP 436
EP 446
DI 10.1093/toxsci/kft248
PG 11
WC Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Toxicology
GA AA2RU
UT WOS:000330942600014
PM 24218149
DA 2025-06-11
ER

PT J
AU Sackmann-Sala, L
   Berryman, DE
   Munn, RD
   Lubbers, ER
   Kopchick, JJ
AF Sackmann-Sala, Lucila
   Berryman, Darlene E.
   Munn, Rachel D.
   Lubbers, Ellen R.
   Kopchick, John J.
TI Heterogeneity Among White Adipose Tissue Depots in Male C57BL/6J Mice
SO OBESITY
LA English
DT Article
ID OBESE ZUCKER RATS; GENE-EXPRESSION; METABOLIC SYNDROME; ADIPOCYTE SIZE;
   FAT; BIOMARKERS; ENDOCRINE; ADIPOKINE; ISOFORM; HUMANS
AB The widespread prevalence of obesity has lead to extensive research on white adipose tissue (WAT), which frequently uses the C57BL/6J mouse strain as a model. In many studies, results obtained in one WAT depot are often extrapolated to all WAT. However, functional differences among WAT depots are now becoming apparent. Thus, to identify the molecular mechanisms responsible for WAT depot-specific differences under "normal" conditions, four C57BL/6J mouse WAT depots (inguinal, mesenteric, epididymal, and retroperitoneal) were analyzed. Depot proteomic profiles, along with weights, protein contents, adipocyte sizes and oxidative stress were determined. Mesenteric WAT had almost twice the protein content of the other depots analyzed. Mean adipocyte size was highest in epididymal and lowest in mesenteric and inguinal depots. The proteome of inguinal WAT displayed low levels of enzymes involved in ATP generation, glucose and lipid metabolism, and antioxidant proteins. Higher levels of these proteins were observed in mesenteric and epididymal WAT, with variable levels in the retroperitoneal depot. Some of these proteins showed depot-specific correlations with plasma levels of insulin, leptin, and adiponectin. In agreement with the proteomic data, levels of the antioxidant protein heat shock protein beta 1 (HSP beta 1) also were lower in inguinal WAT when analyzed by western blotting and immunohistochemistry. Also, lipid peroxidation products showed similar trends. Our results are consistent with lower triglyceride turnover and lower oxidative stress in inguinal than mesenteric and epididymal WAT. The observed WAT depot-specific differences provide clues as to the mechanisms leading to these depots' respective diverse functions.
C1 [Sackmann-Sala, Lucila; Berryman, Darlene E.; Munn, Rachel D.; Lubbers, Ellen R.; Kopchick, John J.] Ohio Univ, Edison Biotechnol Inst, Athens, OH 45701 USA.
   [Sackmann-Sala, Lucila] Ohio Univ, Coll Arts & Sci, Dept Biol Sci, Athens, OH 45701 USA.
   [Sackmann-Sala, Lucila; Berryman, Darlene E.; Kopchick, John J.] Ohio Univ, Mol & Cellular Biol Program, Athens, OH 45701 USA.
   [Berryman, Darlene E.] Ohio Univ, Coll Hlth Sci & Profess, Sch Appl Hlth Sci & Wellness, Athens, OH 45701 USA.
   [Kopchick, John J.] Ohio Univ, Coll Osteopath Med, Dept Biomed Sci, Athens, OH 45701 USA.
C3 University System of Ohio; Ohio University; University System of Ohio;
   Ohio University; University System of Ohio; Ohio University; University
   System of Ohio; Ohio University; University System of Ohio; Ohio
   University
RP Kopchick, JJ (corresponding author), Ohio Univ, Edison Biotechnol Inst, Athens, OH 45701 USA.
EM kopchick@ohio.edu
RI Sackmann Sala, Lucila/A-6483-2011
OI Sackmann Sala, Lucila/0000-0001-5505-9497; Berryman,
   Darlene/0000-0003-4240-9229; Lubbers, Ellen/0000-0002-0357-5681
FU State of Ohio's Eminent Scholar Program; Milton and Lawrence Goll; NIH
   [DK075436-01, AG019899-06, 1P01AG031736-01A1]; Diabetes Research
   Initiative; Ohio University; AMVETS
FX We thank Y. Ikeno at the Barshop Institute for Longevity and Aging
   Studies, UTHSCSA, University of Texas, San Antonio for processing the
   WAT samples for histology. This work was supported in part by the State
   of Ohio's Eminent Scholar Program that includes a gift from Milton and
   Lawrence Goll (J.J.K.), by NIH Grants DK075436-01 (J.J.K.), AG019899-06
   (J.J.K.), and 1P01AG031736-01A1 (J.J.K., D.E.B.), by the Diabetes
   Research Initiative (L.S.-S., D.E.B., E.R.L.) and the BioMolecular
   Innovation and Technology Partnership (L.S.-S.) at Ohio University, and
   by AMVETS (J.J.K.). This work is MIAPE-compliant.
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NR 40
TC 74
Z9 83
U1 0
U2 12
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1930-7381
EI 1930-739X
J9 OBESITY
JI Obesity
PD JAN
PY 2012
VL 20
IS 1
BP 101
EP 111
DI 10.1038/oby.2011.235
PG 11
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 866SB
UT WOS:000298401400010
PM 21779095
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Cortón, M
   Botella-Carretero, JI
   Benguría, A
   Villuendas, G
   Zaballos, A
   San Millán, JL
   Escobar-Morreale, HF
   Peral, B
AF Corton, Marta
   Botella-Carretero, Jose I.
   Benguria, Alberto
   Villuendas, Gemma
   Zaballos, Angel
   San Millan, Jose L.
   Escobar-Morreale, Hector F.
   Peral, Belen
TI Differential gene expression profile in omental adipose tissue in women
   with polycystic ovary syndrome
SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Article
ID 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1; INSULIN-RESISTANCE; SERINE
   PHOSPHORYLATION; OXIDATIVE STRESS; LIPID-METABOLISM; HYPERANDROGENISM;
   TESTOSTERONE; ETIOLOGY; LEPTIN; TOOLS
AB Context: The polycystic ovary syndrome ( PCOS) is frequently associated with visceral obesity, suggesting that omental adipose tissue might play an important role in the pathogenesis of the syndrome.
   Objective: The objective was to study the expression profiles of omental fat biopsy samples obtained from morbidly obese women with or without PCOS at the time of bariatric surgery.
   Design: This was a case-control study. Settings: We conducted the study in an academic hospital.
   Patients: Eight PCOS patients and seven nonhyperandrogenic women submitted to bariatric surgery because of morbid obesity.
   Interventions: Biopsy samples of omental fat were obtained during bariatric surgery.
   Main Outcome Measure: The main outcome measure was high-density oligonucleotide arrays.
   Results: After statistical analysis, we identified changes in the expression patterns of 63 genes between PCOS and control samples. Gene classification was assessed through data mining of Gene Ontology annotations and cluster analysis of dysregulated genes between both groups. These methods highlighted abnormal expression of genes encoding certain components of several biological pathways related to insulin signaling and Wnt signaling, oxidative stress, inflammation, immune function, and lipid metabolism, as well as other genes previously related to PCOS or to the metabolic syndrome.
   Conclusion: The differences in the gene expression profiles in visceral adipose tissue of PCOS patients compared with nonhyperandrogenic women involve multiple genes related to several biological pathways, suggesting that the involvement of abdominal obesity in the pathogenesis of PCOS is more ample than previously thought and is not restricted to the induction of insulin resistance.
C1 Hosp Ramon & Cajal, Dept Endocrinol, E-28034 Madrid, Spain.
   CSIC, Inst Invest Biomed, E-28029 Madrid, Spain.
   Univ Autonoma Madrid, E-28029 Madrid, Spain.
   Univ Alcala de Henares, Alcala De Henares, Spain.
   Hosp Univ Ramon y Cajal, Dept Mol Genet, E-28034 Madrid, Spain.
   CSIC, Ctr Nacl Biotecnol, E-28049 Madrid, Spain.
   Univ Autonoma Madrid, E-28049 Madrid, Spain.
C3 Hospital Universitario Ramon y Cajal; Consejo Superior de
   Investigaciones Cientificas (CSIC); CSIC - Instituto de Investigaciones
   Biomedicas Alberto Sols (IIBM); Autonomous University of Madrid;
   Universidad de Alcala; Hospital Universitario Ramon y Cajal; Consejo
   Superior de Investigaciones Cientificas (CSIC); CSIC - Centro Nacional
   de Biotecnologia (CNB); Autonomous University of Madrid
RP Escobar-Morreale, HF (corresponding author), Hosp Ramon & Cajal, Dept Endocrinol, Carretera Colmenar Km 9 1, E-28034 Madrid, Spain.
EM hescobarm.hrc@salud.madrid.org; bperal@iib.uam.es
RI Zaballos, Ángel/O-2853-2015; Corton, Marta/HLW-7274-2023; San-Millán,
   José/F-9944-2015; Botella-Carretero, Jose I./DGQ-8720-2022; PERAL,
   BELEN/F-4562-2015; Escobar-Morreale, Hector/G-5468-2010; Benguria,
   Alberto/M-9911-2014
OI PERAL, BELEN/0000-0003-4984-4020; Escobar-Morreale,
   Hector/0000-0002-6890-1644; Zaballos, Angel/0000-0002-7555-5815;
   Botella-Carretero, Jose I./0000-0002-6425-2747; Corton,
   Marta/0000-0003-0087-1626; Benguria, Alberto/0000-0002-5536-566X
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NR 57
TC 140
Z9 150
U1 0
U2 13
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0021-972X
EI 1945-7197
J9 J CLIN ENDOCR METAB
JI J. Clin. Endocrinol. Metab.
PD JAN
PY 2007
VL 92
IS 1
BP 328
EP 337
DI 10.1210/jc.2006-1665
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 123TB
UT WOS:000243317500057
PM 17062763
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Bahreiny, SS
   Ahangarpour, A
   Harooni, E
   Amraei, M
   Aghaei, M
   Fard, RM
AF Bahreiny, Seyed Sobhan
   Ahangarpour, Akram
   Harooni, Elnaz
   Amraei, Mahdi
   Aghaei, Mojtaba
   Fard, Reza Mohammadpour
TI Closer look at circulating nitric oxide levels and their association
   with polycystic ovary syndrome: A meta-analytical exploration
SO INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE
LA English
DT Review
DE Polycystic ovary syndrome; Nitric oxide; Oxidative stress; Meta-analysis
ID OXIDATIVE STRESS MARKERS; INSULIN-RESISTANCE; ENDOTHELIAL DYSFUNCTION;
   METABOLIC SYNDROME; LIPID-METABOLISM; PARAOXONASE 1; SERUM-LEVELS;
   YOUNG-WOMEN; MECHANISMS; ADIPONECTIN
AB Background: Polycystic ovary syndrome (PCOS) casts a wide shadow over the reproductive health of millions of women worldwide, emerging as one of the most complex and multifaceted endocrine disorders. In addition, nitric oxide (NO) stands out as a pivotal signaling molecule, orchestrating a symphony of physiological processes. Objective: This meta-analysis aims to elucidate the association between NO levels and PCOS, investigate the potential of NO as a biomarker for PCOS diagnosis, and evaluate its clinical significance. Materials and Methods: A systematic review was conducted in several electronic databases, including PubMed, Web of Science, Cochrane Library, Scopus, EMBASE, and Google Scholar, to identify relevant studies published up to January 2024. Standardized mean difference and 95% CI were calculated using a random effects model to assess the overall effect size. Meta-regressions and subgroup analysis were performed to investigate sources of heterogeneity. Results: A meta-analysis of 14 studies with 1171 participants showed that NO levels were significantly lower in the PCOS group than in the control group. The pooled analysis yielded a standardized mean difference of-0.482; 95% CI:-0.908 to-0.056; p = 0.027. Subgroup analyses further demonstrated variations in NO levels between different PCOS phenotypes and in relation to metabolic parameters. Conclusion: This meta-analysis provides evidence for an association between PCOS and dysregulated NO levels and suggests a potential role of NO as a biomarker in the diagnosis and pathogenesis of PCOS.
C1 [Bahreiny, Seyed Sobhan; Harooni, Elnaz; Amraei, Mahdi; Aghaei, Mojtaba; Fard, Reza Mohammadpour] Ahvaz Jundishapur Univ Med Sci, Student Res Comm, Golestan St, Ahvaz, Iran.
   [Bahreiny, Seyed Sobhan; Ahangarpour, Akram; Harooni, Elnaz] Ahvaz Jundishapur Univ Med Sci, Med Basic Sci Res Inst, Physiol Res Ctr, Sch Med,Dept Physiol, Ahvaz, Iran.
   [Fard, Reza Mohammadpour] Ahvaz Jundishapur Univ Med Sci, Sch Med, Dept Immunol, Ahvaz, Iran.
C3 Ahvaz Jundishapur University of Medical Sciences (AJUMS); Ahvaz
   Jundishapur University of Medical Sciences (AJUMS); Ahvaz Jundishapur
   University of Medical Sciences (AJUMS)
RP Fard, RM (corresponding author), Ahvaz Jundishapur Univ Med Sci, Student Res Comm, Golestan St, Ahvaz, Iran.
EM mohammadpour.r@ajums.ac.ir
RI ahangarpour, akram/I-7638-2017; Aghaei, Mojtaba/KTU-5618-2024; Bahreiny,
   Seyed Sobhan/IUP-5869-2023
OI Mohammadpour Fard, Reza/0009-0008-3588-1633
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NR 61
TC 3
Z9 3
U1 0
U2 0
PU SHAHID SADOUGHI UNIV MEDICAL SCIENCES
PI YAZD
PA Central Administration, Bahonar Sq, YAZD, IRAN
SN 2476-4108
EI 2476-3772
J9 INT J REPROD BIOMED
JI Int. J. Reprod. Biomed.
PD DEC
PY 2024
VL 22
IS 12
BP 943
EP 962
DI 10.18502/ijrm.v22i12.18061
PG 20
WC Obstetrics & Gynecology
WE Emerging Sources Citation Index (ESCI)
SC Obstetrics & Gynecology
GA 0ZE6J
UT WOS:001459506700001
PM 39968366
OA gold
DA 2025-06-11
ER

PT J
AU El-Dein, AN
   Ezzat, A
   Aly, HF
   Younis, EA
   Awad, GA
   Farid, MAM
AF El-Dein, Asmaa Negm
   Ezzat, Asmaa
   Aly, Hanan Farouk
   Younis, Eman A.
   Awad, Ghada A.
   Farid, Mohamed A. M.
TI Hypouricemic, anti-inflammatory, and antioxidant activities of
   Lactobacillus-based functional yogurt in induced-arthritic male Wistar
   rats: Therapeutic and protective potentials
SO BIOCATALYSIS AND AGRICULTURAL BIOTECHNOLOGY
LA English
DT Article
DE Lactobacilli; Uricase; Arthritis; Inflammatory markers;
   Immunohistochemistry
ID BILE-SALT HYDROLASE; BACTERIA; URICASE; HYPERURICEMIA; INHIBITION;
   INFLAMMATION; EXPRESSION; MECHANISM; STRESS; MODEL
AB Hyperuricemia is the increased serum uric acid concentration, associated with metabolic syndrome that commonly leads to heart disease, gout, and chronic nephropathy. In animals, uric acid can be oxidized by the uricase enzyme and excreted in the urine. Unfortunately, humans lack uricase. This study aimed to find uricase-producing probiotic lactobacilli. L. plantarum KU985438 and L. rhamnosus KU985439 were selected to produce functional fermented yogurts. Inducedhyperuricemic animal models were used to test the yogurts' hypouricemic, anti-inflammatory, and antioxidant effects. Male Wistar rats fed probiotics orally for seven days showed decreased levels of uric acid and ankle edema in the therapeutic and protective groups compared to the control (indomethacin-treated). The two yogurts also reduced TNF-alpha, IL-1 beta, and NF-kB concentrations in inflamed joints by decreasing oxidative stress. Histopathology showed arthritis rats with abnormalities, deformities, necrosis, and edema in their joints. In the protective group, the synovial membrane and articular surface were nearly normal with the administration of the two yogurts concurrently with hyperuricemia induction. In the therapeutic group, retrieval from hyperuricemia was observed after 7 days of probiotic administration. Immuno-staining of the reactive immune cells (iNOS) in arthritic rats showed high expression levels. Both conventional medicine and yogurts reduced immune-reactive cell activity in arthritis-affected rats. To the authors' knowledge, this study is considered the first to explore the efficacy of lactobacilli on the reactive immune cell expression in arthritic rats. In conclusion, L. plantarum and L. rhamnosus, with potent therapeutic and protective efficacy against MSU-induced arthritis, could be used as functional food supplements.
C1 [El-Dein, Asmaa Negm; Ezzat, Asmaa; Awad, Ghada A.; Farid, Mohamed A. M.] Natl Res Ctr, Pharmaceut & Drug Ind Res Inst, Dept Chem Nat & Microbial Prod, Giza, Egypt.
   [Aly, Hanan Farouk; Younis, Eman A.] Natl Res Ctr, Pharmaceut & Drug Ind Res Inst, Dept Therapeut Chem, Giza, Egypt.
   [El-Dein, Asmaa Negm] Natl Res Ctr, El Tahrir St, Giza 12622, Egypt.
C3 Egyptian Knowledge Bank (EKB); National Research Centre (NRC); Egyptian
   Knowledge Bank (EKB); National Research Centre (NRC); Egyptian Knowledge
   Bank (EKB); National Research Centre (NRC)
RP El-Dein, AN (corresponding author), Natl Res Ctr, El Tahrir St, Giza 12622, Egypt.
EM an.ahmed@nrc.sci.eg
RI Negm El-Dein, Asmaa/AEZ-9593-2022
OI Ezzat, Asmaa/0000-0002-1493-0386; Negm El-Dein,
   Asmaa/0000-0002-8177-925X
FU Chemistry of Natural and Microbial Products Department and Therapeutic
   Chemistry Department; Pharmaceutical and Drug Industries Research
   Institute; National Research Center, Dokki, Giza, Egypt
FX This work was supported by Chemistry of Natural and Microbial Products
   Department and Therapeutic Chemistry Department, Pharmaceutical and Drug
   Industries Research Institute, National Research Center, Dokki, Giza,
   Egypt. We would like to thank Dr. Heba Shawky, the researcher at
   Therapeutic Chemistry Department for her help during this work.
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NR 57
TC 5
Z9 5
U1 3
U2 18
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
EI 1878-8181
J9 BIOCATAL AGR BIOTECH
JI Biocatal. Agric. Biotechnol.
PD JAN
PY 2023
VL 47
AR 102597
DI 10.1016/j.bcab.2022.102597
EA JAN 2023
PG 14
WC Biotechnology & Applied Microbiology
WE Emerging Sources Citation Index (ESCI)
SC Biotechnology & Applied Microbiology
GA E6VE8
UT WOS:000976888800001
DA 2025-06-11
ER

PT J
AU Sótoudeh, G
   Abshirini, M
   Bagheri, F
   Siassi, F
   Koohdani, F
   Aslany, Z
AF Sotoudeh, Gity
   Abshirini, Maryam
   Bagheri, Fariba
   Siassi, Fereydoun
   Koohdani, Fariba
   Aslany, Zahra
TI Higher dietary total antioxidant capacity is inversely related to
   prediabetes: A case-control study
SO NUTRITION
LA English
DT Article
DE Dietary total antioxidant capacity; Oxidative stress; Fasting blood
   sugar; Prediabetes
ID OXIDATIVE STRESS; METABOLIC SYNDROME; GLUCOSE; OBESITY; COHORT; ADULTS;
   ADOLESCENTS; CHILDREN; HEALTHY; CANCER
AB Objectives: Dietary total antioxidant capacity (DTAC) has been proposed as a tool for assessing the intake of antioxidants. The relationship between DTAC and blood glucose levels has been investigated mostly in healthy people. The aim of this study was to evaluate the association between DTAC and prediabetes morbidity in a case-control study.
   Methods: We examined 300 individuals with and without prediabetes (n = 150/group) who attended a Diabetes Screening Center in Shahreza, Iran. The anthropometric measures, physical activity, and blood glucose levels of all participants were measured. Food intake over the previous year was determined using a semiquantitative food frequency questionnaire, and sex-specific, energy-adjusted DTAC was calculated using the U.S. Department of Agriculture's database. Logistic reg/ression was used to model the relationship between DTAC and prediabetes morbidity.
   Results: The mean DTAC was significantly lower in individuals with prediabetes than in the control group (P < 0.001). Across increasing DTAC quartiles, the participants had lower fasting blood glucose and 2-h postchallenge plasma glucose (P-trend < 0.02). After adjustment for body mass index; physical activity; education; dietary intake of fiber, fat, energy, and coffee; participants in the fourth quartile of DTAC were less likely to experience prediabetes compared with those in the first quartile (odds ratio, 0.18; 95% confidence interval, 0.07-0.49).
   Conclusion: The DTAC score appears useful when assessing the antioxidant capacity of diet and to better understand the relationship between diet and prediabetes morbidity. Future studies are needed to confirm the findings from the present study in other populations. (C) 2017 Elsevier Inc. All rights reserved.
C1 [Sotoudeh, Gity; Abshirini, Maryam; Bagheri, Fariba; Siassi, Fereydoun; Aslany, Zahra] Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Community Nutr, Tehran, Iran.
   [Koohdani, Fariba] Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Cellular, Mol Nutr, Tehran, Iran.
C3 Tehran University of Medical Sciences; Tehran University of Medical
   Sciences
RP Sótoudeh, G (corresponding author), Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Community Nutr, Tehran, Iran.
EM Gsotodeh@tums.ac.ir
RI Abshirini, Maryam/V-1065-2019; Sotoudeh, Gity/E-3973-2018; Siassi,
   Fereydoun/D-4991-2018; Koohdani, Fariba/D-1298-2018
OI Sotoudeh, Gity/0000-0001-6541-2581; Siassi,
   Fereydoun/0000-0002-2591-9406; Koohdani, Fariba/0000-0002-7108-5350
FU Tehran University of Medical Sciences
FX This research was supported by Tehran University of Medical Sciences.
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NR 38
TC 25
Z9 26
U1 1
U2 21
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0899-9007
EI 1873-1244
J9 NUTRITION
JI Nutrition
PD FEB
PY 2018
VL 46
BP 20
EP 25
DI 10.1016/j.nut.2017.08.005
PG 6
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA FT2XT
UT WOS:000423010000004
PM 29290350
DA 2025-06-11
ER

PT J
AU Sakata, R
   Nakamura, T
   Torimura, T
   Ueno, T
   Sata, M
AF Sakata, Ryuichiro
   Nakamura, Toru
   Torimura, Takuji
   Ueno, Takato
   Sata, Michio
TI Green tea with high-density catechins improves liver function and fat
   infiltration in non-alcoholic fatty liver disease (NAFLD) patients: A
   double-blind placebo-controlled study
SO INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
LA English
DT Article
DE fatty liver; non-alcoholic fatty liver disease; non-alcoholic
   steatohepatitis; metabolic syndrome; flavonoid; oxidative stress
ID EPIGALLOCATECHIN GALLATE; IN-VITRO; HEPATOCELLULAR-CARCINOMA;
   CRYPTOGENIC CIRRHOSIS; COMPUTED-TOMOGRAPHY; SKELETAL-MUSCLE;
   NATURAL-HISTORY; STEATOHEPATITIS; ASSOCIATION; POLYPHENOLS
AB Catechins, a major component of green tea extract, have anti-hyperlipidemic effects. The present study investigated the effects of consumption of green tea with high-density catechins in non-alcoholic fatty liver disease (NAFLD) patients. Seventeen patients with NAFLD consumed green tea with high-density catechins, low-density catechins or a placebo for 12 weeks in a randomized double-blind study. Ultrasonography and computed tomography (CT) were performed at baseline and after 12 weeks. Serum alanine aminotransferase (ALT) levels and urine 8-isoprostane were monitored and compared to baseline at 4, 8 and 12 weeks. Body fat was significantly decreased in the high-density catechin group compared with the placebo and low-density catechin groups after 12 weeks of consumption. All the patients in the high-density catechin group showed a significantly improved liver-to-spleen CT attenuation ratio compared with the placebo and low-density catechin groups after 12 weeks of consumption. The high-density catechin group significantly decreased serum ALT levels and reduced urinary 8-isoprostane excretion compared with the placebo and low-density catechin group after 12 weeks of consumption. Based on a reduced proportion of body fat as estimated by bioimpedance measurement, increased liver-to-spleen CT attenuation ratio, decreased serum ALT levels and reduced urinary 8-isoprostane excretion, we concluded that 12 weeks of 700 ml per day of green tea containing >1 g catechin improved liver fat content and inflammation by reducing oxidative stress in patients with NAFLD.
C1 [Sakata, Ryuichiro; Nakamura, Toru; Torimura, Takuji; Sata, Michio] Kurume Univ, Sch Med, Dept Med, Div Gastroenterol, Kurume, Fukuoka 8300011, Japan.
   [Nakamura, Toru; Torimura, Takuji; Ueno, Takato; Sata, Michio] Kurume Univ, Liver Canc Div, Res Ctr Innovat Canc Therapy, Kurume, Fukuoka 8300011, Japan.
   [Ueno, Takato] Asakura Med Assoc Hosp, Asakura 8380069, Japan.
C3 Kurume University; Kurume University
RP Nakamura, T (corresponding author), Kurume Univ, Sch Med, Dept Med, Div Gastroenterol, 67 Asahi Machi, Kurume, Fukuoka 8300011, Japan.
EM ntoru@med.kurume-u.ac.jp
FU Japan National Science Foundation [16590651]; Grants-in-Aid for
   Scientific Research [16590651] Funding Source: KAKEN
FX The study was supported, in part, by the Japan National Science
   Foundation (grant no. 16590651). All the tea was provided by Kao
   Corporation, Japan. However, Kao Corporation was not involved in the
   funding of or in any part of the study. Part of this study was presented
   at the 41st annual meeting of the European Association for the Study of
   the Liver.
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NR 35
TC 90
Z9 96
U1 0
U2 47
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1107-3756
EI 1791-244X
J9 INT J MOL MED
JI Int. J. Mol. Med.
PD NOV
PY 2013
VL 32
IS 5
BP 989
EP 994
DI 10.3892/ijmm.2013.1503
PG 6
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 225SL
UT WOS:000324982500002
PM 24065295
OA Bronze
DA 2025-06-11
ER

PT J
AU Reyskens, KMSE
   Fisher, TL
   Schisler, JC
   O'Connor, WG
   Rogers, AB
   Willis, MS
   Planesse, C
   Rondeau, P
   Bourdon, E
   Essop, MF
AF Reyskens, Kathleen M. S. E.
   Fisher, Tarryn-Lee
   Schisler, Jonathan C.
   O'Connor, Wendi G.
   Rogers, Arlin B.
   Willis, Monte S.
   Planesse, Cynthia
   Rondeau, Philippe
   Bourdon, Emmanuel
   Essop, M. Faadiel
TI The Maladaptive Effects of HIV Protease Inhibitors (Lopinavir/Ritonavir)
   on the Rat Heart
SO PLOS ONE
LA English
DT Article
ID ELEMENT-BINDING PROTEINS; INSULIN SENSITIVITY; PERIPHERAL LIPODYSTROPHY;
   T-LYMPHOCYTES; ATHEROSCLEROSIS; HYPERLIPIDEMIA; DEGRADATION;
   PGC-1-ALPHA; PREVALENCE; MECHANISMS
AB Although antiretroviral treatment decreases HIV-AIDS morbidity/mortality, long-term effects include onset of insulin resistance and cardiovascular diseases. Increased oxidative stress and dysregulation of the ubiquitin-proteasome system (UPS) are implicated in protease-inhibitor (PI)-mediated cardio-metabolic pathophysiology. We hypothesized that PI treatment (Lopinavir/Ritonavir) elevates myocardial oxidative stress and concomitantly inhibits the UPS, thereby attenuating cardiac function. Lopinavir/Ritonavir was dissolved in 1% ethanol (vehicle) and injected into mini-osmotic pumps that were surgically implanted into Wistar rats for 8 weeks vs. vehicle and sham controls. Subsequently, we evaluated metabolic parameters and heart function (ex vivo Langendorff perfusions) at baseline and following ischemia-reperfusion. PI-treated rats exhibited weight gain, increased serum LDL-cholesterol, higher tissue triglycerides (heart, liver), but no evidence of insulin resistance. It also upregulated hepatic gene expression of acetyl-CoA carboxylase beta and 3-hydroxy-3-methylglutaryl-CoA-reductase, key regulators of fatty acid oxidation and cholesterol synthesis, respectively. PI-treated hearts displayed impaired UPS, increased SOD activity and unaltered superoxide levels, and elevated peroxisome proliferator-activated receptor-gamma coactivator 1-alpha (PGC-1 alpha) peptide levels. Perfusion data revealed contractile dysfunction at baseline and following ischemia-reperfusion, while post-ischemic hearts exhibited decreased ATPase specific activity vs. matched controls. Early changes initiated by PI treatment resemble the metabolic syndrome and reflect a pre-atherogenic profile. Moreover, the effects of PIs on cardiac contractile function may in part be triggered by impaired UPS activity together with strain on the mitochondrial energetic system. Our study alerts to cardio-metabolic side effects of PI treatment and raises the question of the most appropriate co-therapies for patients on chronic antiretroviral treatment.
C1 [Reyskens, Kathleen M. S. E.; Fisher, Tarryn-Lee; Essop, M. Faadiel] Univ Stellenbosch, Dept Physiol Sci, Cardiometab Res Grp, ZA-7600 Stellenbosch, South Africa.
   [Schisler, Jonathan C.; O'Connor, Wendi G.; Rogers, Arlin B.; Willis, Monte S.] Univ N Carolina, Dept Pathol & Lab Med, McAllister Heart Inst, Chapel Hill, NC USA.
   [Planesse, Cynthia; Rondeau, Philippe; Bourdon, Emmanuel] Univ Reunion, Grp Etud Inflammat Chron & Obes, Plateforme CYROI, St Denis, Reunion, France.
C3 Stellenbosch University; University of North Carolina; University of
   North Carolina Chapel Hill; University of La Reunion
RP Essop, MF (corresponding author), Univ Stellenbosch, Dept Physiol Sci, Cardiometab Res Grp, ZA-7600 Stellenbosch, South Africa.
EM mfessop@sun.ac.za
RI Willis, Monte/J-9994-2015; rondeau, philippe/F-6755-2015; Bourdon,
   Emmanuel/P-8455-2019; Schisler, Jonathan/C-1301-2008
OI Essop, Faadiel/0000-0002-8434-4294; /0000-0002-0769-5816; Schisler,
   Jonathan/0000-0001-7382-2783; Bourdon, Emmanuel/0000-0003-3731-150X
FU South African National Research Foundation; Stellenbosch University;
   Conseil Regional de La Reunion; l'Europethe Jefferson; Pilot Fellowship
   in Academic Medicine
FX This work was supported by the South African National Research
   Foundation and Stellenbosch University (MFE), the Conseil Regional de La
   Reunion and l'Europethe Jefferson (EB), and a Pilot Fellowship in
   Academic Medicine (MSW). The funders had no role in study design, data
   collection and analysis, decision to publish, or preparation of the
   manuscript.
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NR 54
TC 38
Z9 41
U1 0
U2 12
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD SEP 30
PY 2013
VL 8
IS 9
AR e73347
DI 10.1371/journal.pone.0073347
PG 11
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 231NL
UT WOS:000325423500006
PM 24098634
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Strakovsky, RS
   Pan, YX
AF Strakovsky, Rita S.
   Pan, Yuan-Xiang
TI In Utero Oxidative Stress Epigenetically Programs Antioxidant
   Defense Capacity and Adulthood Diseases
SO ANTIOXIDANTS & REDOX SIGNALING
LA English
DT Review
ID HIGH-FAT DIET; POLYCYCLIC AROMATIC-HYDROCARBONS; SUPEROXIDE-DISMUTASE
   EXPRESSION; PULMONARY ARTERIAL-HYPERTENSION; MATERNAL PROTEIN
   RESTRICTION; GENE-EXPRESSION; DNA METHYLATION; BISPHENOL-A;
   DEVELOPMENTAL ORIGINS; HYDROGEN-PEROXIDE
AB Significance: Maternal health and diet during gestation are critical for predicting fetal outcomes, both immediately at birth and in adulthood. While epigenetic modifications have previously been tightly linked to carcinogenesis, recent advances in the field have suggested that numerous adulthood diseases, including those characteristic of metabolic syndrome, could be programmed in utero in response to maternal exposures, and these "programmable" diseases are associated with epigenetic modifications of vital genes. Recent Advances: While little is currently known about the epigenetic regulation of the antioxidant (AOX) defense system, several studies in animals show that AOX defense capacity may be programmed in utero, making it likely that the critical genes involved in this pathway are epigenetically regulated, either by DNA methylation or by the modification of histone tails. Critical Issues: This article presents the most current knowledge of the in utero regulation of the AOX defense capacity, and will specifically focus on the potential epigenetic regulation of this system in response to various in utero exposures or stimuli. The ability to appropriately respond to oxidative stress is critical for the health and survival of any organism, and the potential programming of this capacity may provide a link between the in utero environment and the tendency of certain individuals to be more susceptible toward disease stimuli in their postnatal environments. Future Directions: We sincerely hope that future studies which result in a deeper understanding of the in utero programming of the epigenome will lead to novel and effective therapies for the treatment of epigenetically linked diseases. Antioxid. Redox Signal. 17, 237-253.
C1 [Strakovsky, Rita S.; Pan, Yuan-Xiang] Univ Illinois, Div Nutr Sci, Urbana, IL 61801 USA.
   [Pan, Yuan-Xiang] Univ Illinois, Dept Food Sci & Human Nutr, Urbana, IL 61801 USA.
C3 University of Illinois System; University of Illinois Urbana-Champaign;
   University of Illinois System; University of Illinois Urbana-Champaign
RP Pan, YX (corresponding author), Univ Illinois, Dept Food Sci & Human Nutr, 461 Bevier Hall,905 S Goodwin Ave, Urbana, IL 61801 USA.
EM yxpan@illinois.edu
RI Pan, Yuan-Xiang/C-6576-2019
OI Pan, Yuan-Xiang/0000-0003-3219-4367
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NR 140
TC 27
Z9 32
U1 0
U2 11
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1523-0864
EI 1557-7716
J9 ANTIOXID REDOX SIGN
JI Antioxid. Redox Signal.
PD JUL
PY 2012
VL 17
IS 2
BP 237
EP 253
DI 10.1089/ars.2011.4372
PG 17
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 944MQ
UT WOS:000304207700006
PM 22035055
OA Green Published
DA 2025-06-11
ER

PT J
AU Zheng, J
   Chen, LL
   Zhang, HH
   Hu, X
   Kong, W
   Hu, D
AF Zheng, Juan
   Chen, Lu-Lu
   Zhang, Hao-Hao
   Hu, Xiang
   Kong, Wen
   Hu, Di
TI Resveratrol improves insulin resistance of catch-up growth by increasing
   mitochondrial complexes and antioxidant function in skeletal muscle
SO METABOLISM-CLINICAL AND EXPERIMENTAL
LA English
DT Article
ID CALORIE RESTRICTION; METABOLIC SYNDROME; OXIDATIVE STRESS;
   CARDIAC-MUSCLE; BIOGENESIS; SIRT1; FAT; DYSFUNCTION; TISSUE; PGC-1-ALPHA
AB Caloric restriction followed by refeeding, a phenomenon known as catch-up growth (CUG), affects mitochondrial function and results in systemic insulin resistance (IR). we investigated the potential of resveratrol (RES) in CUG to prevent IR by increasing activity of the mitochondrial respiratory chain and antioxidant enzymes in skeletal muscle. Rats (8 weeks of age) were divided into 3 groups: normal chow, CUG, and CUG with RES intervention. Skeletal muscle and systemic IR were measured in each group after 4 and 8 weeks. Mitochondrial biogenesis and function, oxidative stress levels, and antioxidant enzyme activity in skeletal muscle were assessed. Catch-up growth-induced IR resulted in significant reductions in both average glucose infusion rate(60-120) at euglycemia and skeletal muscle glucose uptake. Mitochondrial citrate synthase activity was lower; and the activity of complexes I to IV in the intermyofibrillar and subsarcolemmal (SS) mitochondria were reduced by 20% to 40%, with the decrease being more pronounced in the SS fraction. Reactive oxygen species levels were significantly higher in intermyofibrillar and SS mitochondria, whereas activities of antioxidant enzymes were decreased. Oral administration of RES, however, increased silent information regulator 1 activity and improved mitochondrial number and insulin sensitivity. Resveratrol treatment decreased levels of reactive oxygen species and restored activities of antioxidant enzymes. This study demonstrates that RES protects insulin sensitivity of skeletal muscle by improving activities of mitochondrial complexes and antioxidant defense status in CUG rats. Thus, RES has therapeutic potential for preventing CUG-related metabolic disorders. (c) 2012 Published by Elsevier Inc.
C1 [Zheng, Juan; Chen, Lu-Lu; Zhang, Hao-Hao; Hu, Xiang; Kong, Wen; Hu, Di] Huazhong Univ Sci & Technol, Tongji Med Coll, Union Hosp, Dept Endocrinol, Wuhan 430022, Peoples R China.
C3 Huazhong University of Science & Technology
RP Chen, LL (corresponding author), Huazhong Univ Sci & Technol, Tongji Med Coll, Union Hosp, Dept Endocrinol, Wuhan 430022, Peoples R China.
EM cheria_chen@126.com
RI Chen, Lulu/AAV-2389-2021; Kong, Wen/GQH-3057-2022
FU National Natural Science Foundation of China [30771035]
FX This work was supported by National Natural Science Foundation of China
   grant 30771035.
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Z9 50
U1 0
U2 21
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0026-0495
EI 1532-8600
J9 METABOLISM
JI Metab.-Clin. Exp.
PD JUL
PY 2012
VL 61
IS 7
BP 954
EP 965
DI 10.1016/j.metabol.2011.11.005
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 960EV
UT WOS:000305371700007
PM 22209670
DA 2025-06-11
ER

PT J
AU Filiopoulos, V
   Hadjiyannakos, D
   Vlassopoulos, D
AF Filiopoulos, Vassilis
   Hadjiyannakos, Dimitrios
   Vlassopoulos, Dimosthenis
TI New Insights into Uric Acid Effects on the Progression and Prognosis of
   Chronic Kidney Disease
SO RENAL FAILURE
LA English
DT Review
DE arterial hypertension; renal disease progression; uric acid;
   hyperuricemia; chronic kidney disease
ID GLOMERULAR-FILTRATION-RATE; CORONARY-HEART-DISEASE; BLOOD-PRESSURE;
   CARDIOVASCULAR-DISEASE; RENAL-FUNCTION; RISK-FACTORS; ENDOTHELIAL
   DYSFUNCTION; DIABETES-MELLITUS; OXIDATIVE STRESS; HYPERURICEMIA
AB Hyperuricemia is particularly common in patients with arterial hypertension, metabolic syndrome, or kidney disease. Its role, however, as a risk factor for both renal and cardiovascular outcomes and in the context of the well-established interrelationship between cardiovascular disease and chronic kidney disease (CKD) is debated. For decades high serum uric acid levels were mainly considered the result of renal dysfunction and not a true mediator of renal disease development and progression. However, recent epidemiological studies suggest an independent association between asymptomatic hyperuricemia and increased risk of arterial hypertension, CKD, cardiovascular events, and mortality. Furthermore, data from experimental models of hyperuricemia have provided robust evidence in this direction. Hyperuricemia causes increased arterial pressure, proteinuria, renal dysfunction, and progressive renal and vascular disease in rats. The main pathophysiological mechanisms of these deleterious effects caused by uric acid are endothelial dysfunction, activation of local renin-angiotensin system, increased oxidative stress, and proinflammatory and proliferative actions. A small number of short-term, single-center clinical studies support the beneficial influence of pharmaceutical reduction of serum uric acid on total cardiovascular risk, as well as on renal disease development and progression. Hyperuricemia is probably related to the incidence of primary hypertension in children and adolescents, as serum uric acid lowering by allopurinol has an antihypertensive action in this group of patients. Finally, it is clear that adequately powered randomized controlled trials are urgently required to elucidate the role of uric acid in cardiovascular events and outcomes, as well as in the development and progression of CKD.
C1 [Filiopoulos, Vassilis; Hadjiyannakos, Dimitrios; Vlassopoulos, Dimosthenis] Amalia Fleming Gen Hosp, Dept Nephrol, Athens, Greece.
RP Filiopoulos, V (corresponding author), Amalia Fleming Hosp, Dept Nephrol, 25th Martiou 14, Athens 15127, Greece.
EM vassilis.filiopoulos@hotmail.com
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NR 86
TC 109
Z9 128
U1 2
U2 27
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0886-022X
EI 1525-6049
J9 RENAL FAILURE
JI Ren. Fail.
PY 2012
VL 34
IS 4
BP 510
EP 520
DI 10.3109/0886022X.2011.653753
PG 11
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 922QC
UT WOS:000302561800019
PM 22260409
OA Bronze
DA 2025-06-11
ER

PT J
AU Paschke, L
   Zemleduch, T
   Rucinski, M
   Ziolkowska, A
   Szyszka, M
   Malendowicz, LK
AF Paschke, Lukasz
   Zemleduch, Tomasz
   Rucinski, Marcin
   Ziolkowska, Agnieszka
   Szyszka, Marta
   Malendowicz, Ludwik K.
TI Adiponectin and adiponectin receptor system in the rat adrenal gland:
   Ontogenetic and physiologic regulation, and its involvement in
   regulating adrenocortical growth and steroidogenesis
SO PEPTIDES
LA English
DT Article
DE Adiponectin; Adiponectin receptors; Rat; Cell culture; Steroidogenesis;
   Adrenal cortex; Adipose tissue; HPA axis
ID HUMAN ADIPOSE-TISSUE; COMPLEMENT-RELATED PROTEIN; CULTURED RAT;
   INSULIN-RESISTANCE; HUMAN ADIPOCYTES; GENE-EXPRESSION; ALDOSTERONE
   SECRETION; ENDOCRINE DISRUPTORS; CELL-PROLIFERATION; METABOLIC SYNDROME
AB Adiponectin (ADN) is a regulatory peptide secreted mostly by adipose tissue and acting via two receptors: AdipoR1 and AdipoR2. Our aim was to investigate expression of adiponectin system genes in the rat adrenal gland as well as its ontogenetic and physiological control. Furthermore, we examined the effects of acute and prolonged activation of HPA axis on ADN system in adipose tissue. By means of QPCR, ADN and AdipoR1 expression was demonstrated in rat adrenal cortex both at mRNA and protein levels, while AdipoR2 could only be detected at mRNA levels. ADN expression level was significantly unregulated in a developing and regenerating adrenal cortex. Globular domain of adiponectin at 10(-9) M stimulated corticosterone output and BrdU incorporation by cultured rat adrenocortical cells. Moreover, both acute (ACTH and ether stress) and prolonged (ACTH) adrenal stimulation resulted in lowered ADN levels, while expression of AdipoR1 and AdipoR2 was unregulated by the acute treatment. Depending on its site of origin, visceral (VAT) or subcutaneous (SAT) adipose tissue responded differently to alterations in HPA axis. VAT expression of ADN and its receptors remained almost unchanged by experimental manipulations. In SAT, on the other hand, expression of ADN and AdipoR2 was markedly increased by ACTH treatment and stress, while dexamethasone suppressed ADN and AdipoR1 mRNA levels. The results of this study provide new evidence for direct and indirect interactions between adipokines and HPA axis. (C) 2010 Published by Elsevier Inc.
C1 [Paschke, Lukasz; Zemleduch, Tomasz; Rucinski, Marcin; Ziolkowska, Agnieszka; Szyszka, Marta; Malendowicz, Ludwik K.] Poznan Univ Med Sci, Dept Histol & Embryol, Poznan, Poland.
C3 Poznan University of Medical Sciences
RP Malendowicz, LK (corresponding author), Med Univ, Dept Histol & Embryol, 6 Swiecicki St, PL-60781 Poznan, Poland.
EM lkm@amp.edu.pl
RI Rucinski, Marcin/AID-3528-2022
OI Zemleduch, Tomasz/0000-0002-6126-3758; Rucinski,
   Marcin/0000-0002-2525-5777; Szyszka, Marta/0000-0003-0150-3665
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NR 80
TC 30
Z9 31
U1 0
U2 4
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0196-9781
EI 1873-5169
J9 PEPTIDES
JI Peptides
PD SEP
PY 2010
VL 31
IS 9
BP 1715
EP 1724
DI 10.1016/j.peptides.2010.06.007
PG 10
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism;
   Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism;
   Pharmacology & Pharmacy
GA 644IL
UT WOS:000281368400015
PM 20600433
DA 2025-06-11
ER

PT J
AU Nakhjavani, M
   Khalilzadeh, O
   Khajeali, L
   Esteghamati, A
   Morteza, A
   Jamali, A
   Dadkhahipour, S
AF Nakhjavani, Manouchehr
   Khalilzadeh, Omid
   Khajeali, Leila
   Esteghamati, Alireza
   Morteza, Afsaneh
   Jamali, Arsia
   Dadkhahipour, Sheida
TI Serum Oxidized-LDL is Associated with Diabetes Duration Independent of
   Maintaining Optimized Levels of LDL-Cholesterol
SO LIPIDS
LA English
DT Article
DE Diabetes mellitus; Duration; Ox-LDL
ID LOW-DENSITY-LIPOPROTEIN; CORONARY-ARTERY-DISEASE; METABOLIC SYNDROME;
   OXIDATIVE STRESS; APOLIPOPROTEIN-B; STATIN THERAPY; ATHEROSCLEROSIS;
   COMPLICATIONS; HYPERCHOLESTEROLEMIA; GLYCATION
AB Oxidized low-density lipoprotein (ox-LDL) plays a key role in the progression of atherosclerosis and diabetes complications. The aim of this study was first, to evaluate the association between ox-LDL and diabetes duration, and second, to examine serum level of ox-LDL in patients with prolonged diabetes and a desirable LDL-cholesterol level. A total of 36 type-2 diabetic patients with a diabetes duration of more than 5 years, 36 newly diagnosed diabetic patients, and 36 age-, sex- and BMI-matched healthy participants were recruited. Healthy participants and newly diagnosed patients were not receiving any treatment. All patients with prolonged diabetes had desirable LDL-cholesterol levels (<100 mg/dL), according to the adult treatment panel-III guidelines. While LDL-cholesterol was significantly lower in patients with diabetes duration >5 years, in comparison to newly diagnosed patients (P < 0.01), ox-LDL was significantly higher in patients with prolonged diabetes (P < 0.001). The ox-LDL-to-LDL ratio was dramatically higher in patients with diabetes duration >5 years in comparison to newly diagnosed patients and healthy participants (P < 0.001). Ox-LDL was significantly associated with diabetes duration (r = 0.519, P = 0.001). In multivariate analysis, this association remained significant (beta = 0.501, P = 0.003) after adjustment for potential confounders. In conclusion, this study showed that the serum ox-LDL level increases with the length of diabetes, even though the patients' LDL-cholesterol level is maintained at a desirable level. Our findings highlight that possibly more attention should be focused on markers of oxidative stress in the management of lipids in diabetic patients.
C1 [Nakhjavani, Manouchehr; Khalilzadeh, Omid; Khajeali, Leila; Esteghamati, Alireza; Morteza, Afsaneh; Jamali, Arsia; Dadkhahipour, Sheida] Univ Tehran Med Sci, EMRC, Vali Asr Hosp, Tehran, Iran.
C3 Tehran University of Medical Sciences
RP Nakhjavani, M (corresponding author), Univ Tehran Med Sci, EMRC, Vali Asr Hosp, POB 13145-784, Tehran, Iran.
EM nakhjavanim@tums.ac.ir; khalilzadeh@razi.tums.ac.ir;
   leila_khajehali@yahoo.com; esteghamati@tums.ac.ir; aafsaneh03@gmail.com;
   arsia_jamali@yahoo.com; sdadkhahipour@calpharm.org
RI Nakhjavani, Manouchehr/J-3704-2019; Khalilzadeh, Omid/F-5769-2011
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NR 45
TC 60
Z9 65
U1 0
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0024-4201
EI 1558-9307
J9 LIPIDS
JI Lipids
PD APR
PY 2010
VL 45
IS 4
BP 321
EP 327
DI 10.1007/s11745-010-3401-8
PG 7
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA 573IS
UT WOS:000275906600004
PM 20224977
DA 2025-06-11
ER

PT J
AU Lee, WC
   Lu, SV
   Su, CH
   Tain, YL
   Wu, KLH
   Hsu, CN
   Tzeng, HT
AF Lee, Wei-Chia
   Lu, Steve
   Su, Chia-Hao
   Tain, You-Lin
   Wu, Kay L. H.
   Hsu, Chien-Ning
   Tzeng, Hong-Tai
TI Tadalafil Ameliorates Chronic Ischemia-Associated Bladder Overactivity
   in Fructose-Fed Rats by Exerting Pelvic Angiogenesis and Enhancing
   p-eNOS Expression
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE angiogenesis; bladder; fructose; ischemia; tadalafil
ID URINARY-TRACT SYMPTOMS; OXIDATIVE STRESS; DYSFUNCTION
AB Metabolic syndrome (MetS) can contribute to a chronic ischemia-relative overactive bladder (OAB). Using fructose-fed rats (FFRs), a rat model of MetS, we investigated the effects of tadalafil (a phosphodiesterase-5 inhibitor) on MetS-associated chronic bladder ischemia and bladder overactivity. Phenotypes of the OAB, including increased micturition frequency and a shortened intercontractile interval in cystometry, were observed in FFRs, together with reduced bladder blood perfusion (in empty bladders) via laser color Doppler imaging and elevated serum nitrite levels, suggesting chronic ischemia-related bladder dysfunction. Treatment with tadalafil (2 mg/kg) promoted pelvic angiogenesis, as shown by magnetic resonance imaging, and increased VEGF and p-eNOS overexpression in the bladder. This treatment restored bladder perfusion and alleviated bladder overactivity without significantly altering most MetS parameters. At the molecular level, FFRs exhibited increased ischemia markers (NGF, HIF-2 alpha, and AMPK-alpha 2) and decreased p-AMPK-alpha 2, along with elevated proinflammatory mediators (ICAM-1, nuclear NF-kappa B, COX-2, IL-1 beta, IL-6, and TNF-alpha), enhanced mitochondria biogenesis (PGC-1 alpha, TFAM, and mitochondria DNA copy number), oxidative stress (decreased nuclear NRF2, increase MnSOD and 8-OHdG staining), and tissue fibrosis (increased TGF-beta 1, collagen I, and fibronectin). Tadalafil treatment improved these effects. Together, these findings suggest that tadalafil may promote VEGF-associated angiogenesis, enhance p-eNOS staining in the bladder vasculature, normalize bladder perfusion in microcirculation, and reduce serum nitrite levels. Consequently, tadalafil mitigates the adverse effects of chronic ischemia/hypoxia, improving bladder overactivity. We elucidated the mechanisms underlying the tadalafil-mediated amelioration of MetS-associated OAB symptoms.
C1 [Lee, Wei-Chia] Chang Gung Univ, Coll Med, Kaohsiung Chang Gung Mem Hosp, Div Urol, Kaohsiung 833, Taiwan.
   [Lu, Steve; Wu, Kay L. H.; Tzeng, Hong-Tai] Kaohsiung Chang Gung Mem Hosp, Inst Translat Res Biomed, Kaohsiung 833, Taiwan.
   [Lu, Steve] Kaohsiung Med Univ, Coll Life Sci, Dept Biotechnol, Kaohsiung 807, Taiwan.
   [Su, Chia-Hao] Chang Gung Univ, Ctr Gen Educ, Taoyuan 333, Taiwan.
   [Su, Chia-Hao] Kaohsiung Chang Gung Mem Hosp, Dept Radiat Oncol, Kaohsiung 833, Taiwan.
   [Su, Chia-Hao] Natl Yang Ming Chiao Tung Univ, Dept Biomed Imaging & Radiol Sci, Taipei 112, Taiwan.
   [Tain, You-Lin] Chang Gung Univ, Kaohsiung Chang Gung Mem Hosp, Coll Med, Dept Pediat, Kaohsiung 833, Taiwan.
   [Hsu, Chien-Ning] Kaohsiung Chang Gung Mem Hosp, Dept Pharm, Kaohsiung 833, Taiwan.
   [Hsu, Chien-Ning] Kaohsiung Med Univ, Sch Pharm, Kaohsiung 807, Taiwan.
C3 Chang Gung University; Chang Gung Memorial Hospital; Chang Gung Memorial
   Hospital; Kaohsiung Medical University; Chang Gung University; Chang
   Gung Memorial Hospital; National Yang Ming Chiao Tung University; Chang
   Gung Memorial Hospital; Chang Gung University; Chang Gung Memorial
   Hospital; Kaohsiung Medical University
RP Tzeng, HT (corresponding author), Kaohsiung Chang Gung Mem Hosp, Inst Translat Res Biomed, Kaohsiung 833, Taiwan.
EM dinor666@ms32.hinet.net; leu@cgmh.org.tw; chiralsu@gmail.com;
   tainyl@hotmail.com; wlh0701@yahoo.com.tw; cnhsu@cgmh.org.tw;
   htay11@cgmh.org.tw
RI Tain, You-Lin/H-2827-2019; Hsu, Chien-Ning/GLS-4014-2022; Wu,
   Kay/ACD-1767-2022
OI Wu, Kay L.H./0000-0002-7297-6788; Hsu, Chien-Ning/0000-0001-7470-528X;
   Lee, Wei-Chia/0000-0003-0701-2285; Tain, You-Lin/0000-0002-7059-6407
FU Ministry of Science and Technology of the Republic of China; Chang Gung
   Medical Foundation [CMRPG8M0742, CMRPG8J0431, CMRPG8K1431]; Chang Gung
   Memorial Hospital;  [MOST 108-2314-B-182A-033-MY3];  [MOST
   111-2314-B-182A-081-MY3]
FX This work is supported by Grants MOST 108-2314-B-182A-033-MY3 and MOST
   111-2314-B-182A-081-MY3 from the Ministry of Science and Technology of
   the Republic of China, and CMRPG8M0742, CMRPG8J0431, and CMRPG8K1431
   from the Chang Gung Medical Foundation and Chang Gung Memorial Hospital.
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NR 49
TC 0
Z9 0
U1 1
U2 1
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD FEB
PY 2025
VL 26
IS 3
AR 1363
DI 10.3390/ijms26031363
PG 14
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA W4X9Q
UT WOS:001418634800001
PM 39941129
OA Green Accepted, gold, Green Published
DA 2025-06-11
ER

PT J
AU Costache, AD
   Ignat, BE
   Grosu, C
   Mastaleru, A
   Abdulan, I
   Oancea, A
   Roca, M
   Leon, MM
   Badescu, MC
   Luca, S
   Jigoranu, AR
   Chetran, A
   Mitu, O
   Costache, II
   Mitu, F
AF Costache, Alexandru Dan
   Ignat, Bogdan Emilian
   Grosu, Cristina
   Mastaleru, Alexandra
   Abdulan, Irina
   Oancea, Andra
   Roca, Mihai
   Leon, Maria Magdalena
   Badescu, Minerva Codruta
   Luca, Stefana
   Jigoranu, Alexandru Raul
   Chetran, Adriana
   Mitu, Ovidiu
   Costache, Irina Iuliana
   Mitu, Florin
TI Inflammatory Pathways in Overweight and Obese Persons as a Potential
   Mechanism for Cognitive Impairment and Earlier Onset Alzeihmer's
   Dementia in the General Population: A Narrative Review
SO BIOMEDICINES
LA English
DT Review
DE obesity; overweight status; cognitive dysfunction; dementia; Alzheimer's
   disease; older population; body mass index; waist-to-hip ratio;
   inflammation; lifestyle intervention; dietary measures
ID BODY-MASS INDEX; MEDITERRANEAN DIET; ALZHEIMERS-DISEASE; WORKING-MEMORY;
   LATE-LIFE; METABOLIC SYNDROME; VISCERAL OBESITY; STRESS HORMONES;
   ADIPOSE-TISSUE; INSULIN SENSITIVITY
AB The overweight status or obesity can be confirmed through classical methods such as the body mass index (BMI) and the waist-to-hip ratio (WHR). Apart from metabolic issues such as atherosclerosis, liver steatosis, or diabetes mellitus, long-term obesity or overweight status can pose a risk for cardiovascular and neurovascular complications. While some acute adverse events like coronary syndromes of strokes are well-documented to be linked to an increased body mass, there are also chronic processes that, due to their silent onset and evolution, are underdiagnosed and not as thoroughly studied. Through this review, we aimed to collect all relevant data with regard to the long-term impact of obesity on cognitive function in all ages and its correlation with an earlier onset of dementia such as Alzheimer's disease (AD). The exact mechanisms through which a decline in cognitive functions occurs in overweight or obese persons are still being discussed. A combination of factors has been acknowledged as potential triggers, such as a sedentary lifestyle and stress, as well as a genetic predisposition, for example, the apolipoprotein E (ApoE) alleles in AD. Most research highlights the impact of vascular dysfunction and systemic inflammation on the nervous system in patients with obesity and the subsequent neurological changes. Obesity during the early to mid-ages leads to an earlier onset of cognitive dysfunction in various forms. Also, lifestyle intervention can reverse cognitive dysfunction, especially dieting, to encourage weight loss.
C1 [Costache, Alexandru Dan; Ignat, Bogdan Emilian; Grosu, Cristina; Mastaleru, Alexandra; Abdulan, Irina; Oancea, Andra; Roca, Mihai; Leon, Maria Magdalena; Badescu, Minerva Codruta; Luca, Stefana; Jigoranu, Alexandru Raul; Chetran, Adriana; Mitu, Ovidiu; Costache, Irina Iuliana; Mitu, Florin] Univ Med & Pharm Grigore T Popa, Fac Med, Iasi 700115, Romania.
   [Costache, Alexandru Dan; Ignat, Bogdan Emilian; Grosu, Cristina; Mastaleru, Alexandra; Abdulan, Irina; Oancea, Andra; Roca, Mihai; Leon, Maria Magdalena; Mitu, Florin] Clin Rehabil Hosp, Iasi 700661, Romania.
   [Badescu, Minerva Codruta; Luca, Stefana; Jigoranu, Alexandru Raul; Chetran, Adriana; Mitu, Ovidiu; Costache, Irina Iuliana] St Spiridon Emergency Cty Hosp, Iasi 700111, Romania.
   [Mitu, Florin] Romanian Acad Med Sci, Bucharest 927180, Romania.
   [Mitu, Florin] Romanian Acad Scientists, Bucharest 050044, Romania.
C3 Grigore T Popa University of Medicine & Pharmacy; Romanian Academy;
   Academy of Romanian Scientists (AOSR)
RP Ignat, BE; Grosu, C (corresponding author), Univ Med & Pharm Grigore T Popa, Fac Med, Iasi 700115, Romania.; Ignat, BE; Grosu, C (corresponding author), Clin Rehabil Hosp, Iasi 700661, Romania.
EM adcostache@yahoo.com; bogdanei@yahoo.com; fcristina_ro@yahoo.com;
   alexandra.mastaleru@gmail.com; irina.abdulan@yahoo.com;
   andra.radulescu@yahoo.com; roca2m@yahoo.com;
   leon_mariamagdalena@yahoo.com; minerva.badescu@umfiasi.ro;
   stefana.luca08@gmail.com; jigoranu.alexandru@yahoo.ro;
   adriana.ion@hotmail.com; mituovidiu@yahoo.co.uk; ii.costache@yahoo.com;
   mitu.florin@yahoo.com
RI Jigoranu, Raul Alexandru/KFB-2017-2024; Abdulan, Irina/AAA-3089-2020;
   Badescu, Minerva/ABC-4333-2021; Leon, Maria/AAP-5791-2021; Mitu,
   Ovidiu/ABA-1011-2021; Oancea, Andra/IAN-9148-2023; Grosu,
   Cristina/LTZ-6641-2024; Luca, Stefana/HKV-5169-2023; Ignat, Emilian
   Bogdan/R-3900-2017; Chetran, ADRIANA/HGB-3629-2022; Mastaleru,
   Alexandra/HFZ-8523-2022
OI Luca, Stefana/0000-0002-9192-7607; Badescu, Minerva
   Codruta/0000-0001-8942-1909; Costache,
   Alexandru-Dan/0000-0001-8544-9904; Ignat, Emilian
   Bogdan/0000-0002-6952-9741; Chetran, ADRIANA/0000-0003-4792-115X;
   Mastaleru, Alexandra/0000-0002-0008-9696; Jigoranu, Raul
   Alexandru/0000-0002-2696-9915; Oancea, Andra/0000-0003-1356-9581
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NR 215
TC 5
Z9 5
U1 3
U2 13
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2227-9059
J9 BIOMEDICINES
JI Biomedicines
PD DEC
PY 2023
VL 11
IS 12
AR 3233
DI 10.3390/biomedicines11123233
PG 25
WC Biochemistry & Molecular Biology; Medicine, Research & Experimental;
   Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Research & Experimental Medicine;
   Pharmacology & Pharmacy
GA DF6Y6
UT WOS:001130666000001
PM 38137454
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Shabalala, SC
   Dludla, PV
   Mabasa, L
   Kappo, AP
   Basson, AK
   Pheiffer, C
   Johnson, R
AF Shabalala, Samukelisiwe C.
   Dludla, Phiwayinkosi, V
   Mabasa, Lawrence
   Kappo, Abidemi P.
   Basson, Albertus K.
   Pheiffer, Carmen
   Johnson, Rabia
TI The effect of adiponectin in the pathogenesis of non-alcoholic fatty
   liver disease (NAFLD) and the potential role of polyphenols in the
   modulation of adiponectin signaling
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Review
DE Nonalcoholic fatty liver diseases; Insulin resistance; Lipid metabolism;
   Oxidative stress; Inflammation; Antioxidants
ID NF-KAPPA-B; ROOIBOS ASPALATHUS-LINEARIS; INDUCED OXIDATIVE STRESS;
   IMPROVES INSULIN-RESISTANCE; ACTIVATED PROTEIN-KINASE; DE-NOVO
   LIPOGENESIS; CHLOROGENIC ACID; LIPID-METABOLISM; IN-VITRO; TNF-ALPHA
AB Non-alcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases worldwide, as it affects up to 30 % of adults in Western countries. Moreover, NAFLD is also considered an independent risk factor for cardiovascular diseases. Insulin resistance and inflammation have been identified as key factors in the pathophysiology of NAFLD. Although the mechanisms associated with the development of NAFLD remain to be fully elucidated, a complex interaction between adipokines and cytokines appear to play a crucial role in the development of this condition. Adiponectin is the most common adipokine known to be inversely linked with insulin resistance, lipid accumulation, inflammation and NAFLD. Consequently, the focus has been on the use of new therapies that may enhance hepatic expression of adiponectin downstream targets or increase the serum levels of adiponectin in the treatment NAFLD. While currently used therapies show limited efficacy in this aspect, accumulating evidence suggest that various dietary polyphenols may stimulate adiponectin levels, offering potential protection against the development of insulin resistance, inflammation and NAFLD as well as associated conditions of metabolic syndrome. As such, this review provides a better understanding of the role polyphenols play in modulating adiponectin signaling to protect against NAFLD. A brief discussion on the regulation of adiponectin during disease pathophysiology is also covered to underscore the potential protective effects of polyphenols against NAFLD. Some of the prominent polyphenols described in the manuscript include aspalathin, berberine, catechins, chlorogenic acid, curcumin, genistein, piperine, quercetin, and resveratrol.
C1 [Shabalala, Samukelisiwe C.; Dludla, Phiwayinkosi, V; Mabasa, Lawrence; Pheiffer, Carmen; Johnson, Rabia] South African Med Res Council SAMRC, Biomed Res & Innovat Platform BRIP, ZA-7505 Tygerberg, South Africa.
   [Shabalala, Samukelisiwe C.; Basson, Albertus K.] Univ Zululand, Fac Sci & Agr, Dept Biochem & Microbiol, ZA-3886 Kwa Dlangezwa, South Africa.
   [Dludla, Phiwayinkosi, V] Polytech Univ Marche, Dept Life & Environm Sci, I-60131 Ancona, Italy.
   [Pheiffer, Carmen; Johnson, Rabia] Stellenbosch Univ, Fac Hlth Sci, Dept Med Physiol, ZA-7505 Tygerberg, South Africa.
   [Kappo, Abidemi P.] Univ Johannesburg, Fac Sci, Dept Biochem, ZA-2006 Auckland Pk, South Africa.
C3 University of Zululand; Marche Polytechnic University; Stellenbosch
   University; University of Johannesburg
RP Johnson, R (corresponding author), South African Med Res Council, Biomed Res & Innovat Platform, POB 19070, ZA-7505 Tygerberg, South Africa.
EM rabia.johnson@mrc.ac.za
RI Johnson, Rabia/ADW-4478-2022
OI , Lawrence/0000-0001-6499-3396; Johnson, Rabia/0000-0002-6328-0789;
   Kappo, Abidemi Paul/0000-0003-2521-8957; Pheiffer,
   Carmen/0000-0002-0707-1552
FU South African Medical Research Council's (SAMRC)/Biomedical Research and
   Innovation Platform baseline fund; NRF Thuthuka Grant [UID107261];
   Competitive Program for Rated Researchers [UID 120812]; NRF Professional
   Development Program [UID104987, UID121188]; South African Rooibos
   Council
FX This work was supported by the South African Medical Research Council's
   (SAMRC)/Biomedical Research and Innovation Platform baseline funding,
   the NRF Thuthuka Grant (UID107261), Competitive Program for Rated
   Researchers (UID 120812), NRF Professional Development Program
   (UID104987 and UID121188) and the South African Rooibos Council.
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NR 229
TC 100
Z9 108
U1 9
U2 56
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD NOV
PY 2020
VL 131
AR 110785
DI 10.1016/j.biopha.2020.110785
PG 17
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA OH6KI
UT WOS:000582699600141
PM 33152943
OA gold
DA 2025-06-11
ER

PT J
AU Yan, JT
   Wang, CY
   Jin, Y
   Meng, Q
   Liu, Q
   Liu, ZH
   Liu, KX
   Sun, HJ
AF Yan, Jiting
   Wang, Changyuan
   Jin, Yue
   Meng, Qiang
   Liu, Qi
   Liu, Zhihao
   Liu, Kexin
   Sun, Huijun
TI Catalpol ameliorates hepatic insulin resistance in type 2 diabetes
   through acting on AMPK/NOX4/PI3K/AKT pathway
SO PHARMACOLOGICAL RESEARCH
LA English
DT Article
DE Type 2 diabetes; Catalpol; Insulin resistance; AMPK; NOX4
ID ACTIVATED PROTEIN-KINASE; HIGH-FAT DIET; INCREASED OXIDATIVE STRESS;
   METABOLIC SYNDROME; MITOCHONDRIAL DYSFUNCTION; GLYCOGEN-SYNTHASE;
   SKELETAL-MUSCLE; RAT-LIVER; DEPENDENT REGULATION; GLUCOSE-HOMEOSTASIS
AB Type 2 diabetes is characterized by insulin resistance in target tissues and hyperglycemia. Catalpol is a natural product isolated from the root of Rehmannia glutinosa, which has been reported to produce the effect of anti-diabetes in recent reports. The goal of the current study is to investigate the therapeutic effects of catalpol on hepatic insulin resistance in type 2 diabetes and elucidate the underlying cellular mechanisms. Type 2 diabetes in vivo was induced by combined high-fat diet (HFD) and streptozotocin (STZ) injection in C57BL/6J mice. Insulin resistance in vitro was induced by glucosamine administration in HepG2 cells. Catalpol exhibited the effects decreasing hepatic gluconeogenesis and increasing hepatic glycogen synthesis both in vivo and in vitro. Additionally, catalpol improved hepatic NADPH oxidase type 4 (NOX4)-mediated oxidative stress and activated hepatic AMP-activated protein kinase (AMPK) and phosphatidylinositol 3-kinase (PI3K)/AICT pathway in vivo and in vitro. The effects of catalpol on preventing gluconeogenesis and increasing glycogen synthesis in glucosamine-induced HepG2 cells were prevented by pretreatment with LY294002, the inhibitor of PI3K. Furthermore, the effect of catalpol on depriving glucosamine-induced insulin resistance was prevented by knockdown of NOX4 or AMPK with short interfering RNA (siRNA) in HepG2 cells. Moreover, the suppressive effect of catalpol on glucosamine-induced NOX4 over-expression was weakened by knockdown of AMPK with siRNA. Taken together, these findings suggested that catalpol ameliorated hepatic insulin resistance in type 2 diabetes through acting on AMPK/NOX4/P13K/AICT pathway. (C) 2017 Elsevier Ltd. All rights reserved.
C1 [Yan, Jiting; Wang, Changyuan; Jin, Yue; Meng, Qiang; Liu, Qi; Liu, Zhihao; Liu, Kexin; Sun, Huijun] Dalian Med Univ, Coll Pharm, Dept Clin Pharmacol, 9 West Sect,Lvshun South Rd, Dalian 116044, Peoples R China.
C3 Dalian Medical University
RP Sun, HJ (corresponding author), Dalian Med Univ, Coll Pharm, Dept Clin Pharmacol, 9 West Sect,Lvshun South Rd, Dalian 116044, Peoples R China.
EM sunhuijun@dlmedu.edu.cn
RI Liu, Kexin/GQH-0970-2022; Liu, Zhihao/J-3504-2019
OI Liu, Zhihao/0000-0003-1644-0679
FU National Natural Science Foundation of China [81273508]
FX This study was supported in part by Grants from the National Natural
   Science Foundation of China (No. 81273508).
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NR 66
TC 175
Z9 187
U1 10
U2 160
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 1043-6618
J9 PHARMACOL RES
JI Pharmacol. Res.
PD APR
PY 2018
VL 130
BP 466
EP 480
DI 10.1016/j.phrs.2017.12.026
PG 15
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA GG9JN
UT WOS:000433016900040
PM 29284152
DA 2025-06-11
ER

PT J
AU Lushchak, VI
   Matviishyn, TM
   Husak, VV
   Storey, JM
   Storey, KB
AF Lushchak, Volodymyr I.
   Matviishyn, Tetiana M.
   Husak, Viktor V.
   Storey, Janet M.
   Storey, Kenneth B.
TI PESTICIDE TOXICITY: A MECHANISTIC APPROACH
SO EXCLI JOURNAL
LA English
DT Review
DE Bioaccumulation; biotransformation; pollutants; mechanisms; oxidative
   stress; xenobiotics
ID INDUCED OXIDATIVE STRESS; 2,4-DICHLOROPHENOXYACETIC ACID 2,4-D;
   CARASSIUS-AURATUS; HEMATOLOGICAL PARAMETERS; COMMERCIAL FORMULATION;
   CHRONIC EXPOSURE; FEMALE RATS; DNA-DAMAGE; PHENOXYACETIC HERBICIDES;
   OREOCHROMIS-NILOTICUS
AB Pesticides are known for their high persistence and pervasiveness in the environment, and along with products of their biotransformation, they may remain in and interact with the environment and living organisms in multiple ways, according to their nature and chemical structure, dose and targets. In this review, the classifications of pesticides based on their nature, use, physical state, pathophysiological effects, and sources are discussed. The effects of these xenobiotics on the environment, their biotransformation in terms of bioaccumulation are highlighted with special focus on the molecular mechanisms deciphered to date. Basing on targeted organisms, most pesticides are classified as herbicides, fungicides, and insecticides. Herbicides are known as growth regulators, seedling growth inhibitors, photosynthesis inhibitors, inhibitors of amino acid and lipid biosynthesis, cell membrane disrupters, and pigment biosynthesis inhibitors, whereas fungicides include inhibitors of ergosterol biosynthesis, protein biosynthesis, and mitochondrial respiration. Insecticides mainly affect nerves and muscle, growth and development, and energy production. Studying the impact of pesticides and other related chemicals is of great interest to animal and human health risk assessment processes since potentially everyone can be exposed to these compounds which may cause many diseases, including metabolic syndrome, malnutrition, atherosclerosis, inflammation, pathogen invasion, nerve injury, and susceptibility to infectious diseases. Future studies should be directed to investigate influence of long term effects of low pesticide doses and to minimize or eliminate influence of pesticides on non-target living organisms, produce more specific pesticides and using modern technologies to decrease contamination of food and other goods by pesticides.
C1 [Lushchak, Volodymyr I.; Matviishyn, Tetiana M.; Husak, Viktor V.] Vasyl Stefanyk Precarpathian Natl Univ, Dept Biochem & Biotechnol, 57 Shevchenko Str, UA-76018 Ivano Frankivsk, Ukraine.
   [Storey, Janet M.; Storey, Kenneth B.] Carleton Univ, Inst Biochem, 1125 Colonel By Dr, Ottawa, ON K1S 5B6, Canada.
C3 Ministry of Education & Science of Ukraine; Vasyl Stefanyk Precarpathian
   National University; Carleton University
RP Lushchak, VI (corresponding author), Vasyl Stefanyk Precarpathian Natl Univ, Dept Biochem & Biotechnol, 57 Shevchenko Str, UA-76018 Ivano Frankivsk, Ukraine.
EM lushchak@pu.if.ua
RI Husak, Viktor/AAF-8512-2020; Lushchak, Volodymyr/AAV-4256-2021; Storey,
   Kenneth/G-9883-2011
OI Lushchak, Volodymyr/0000-0001-5602-3330; Husak,
   Viktor/0000-0001-9415-9837
FU Ministry of Education and Science of Ukraine; Natural Sciences and
   Engineering Research Council of Canada
FX We thank the many members of the V. Lushchak's laboratory who have
   contributed over the years: Drs. T. Bagnyukova, O. Kubrak, O. Lushchak,
   N. Semchuk (Mosiichuk), H. Semchyshyn, O. Vasylkiv, and I. Maksymiv, the
   research reviewed in this article. The works were partially supported by
   the grants from Ministry of Education and Science of Ukraine to VIL and
   a discovery grants from the Natural Sciences and Engineering Research
   Council of Canada to KBS.
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NR 195
TC 368
Z9 394
U1 8
U2 112
PU EXCLI JOURNAL MANAGING OFFICE
PI DORTMUND
PA LEIBNIZ RESEARCH CENTRE WORKING ENVIRONMENT & HUMAN FACTORS EXCLI
   JOURNAL, ARDEYSTR 67, DORTMUND, D-44139, GERMANY
SN 1611-2156
J9 EXCLI J
JI EXCLI J.
PY 2018
VL 17
BP 1101
EP 1136
DI 10.17179/excli2018-1710
PG 36
WC Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics
GA HB0XI
UT WOS:000450741600002
PM 30564086
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Peixoto-Silva, N
   Moura, EG
   Carvalho, JC
   Nobre, JL
   Quitete, FT
   Pinheiro, CR
   Santos-Silva, AP
   de Oliveira, E
   Lisboa, PC
AF Peixoto-Silva, Nayara
   Moura, Egberto G.
   Carvalho, Janaine C.
   Nobre, Jessica L.
   Quitete, Fernanda T.
   Pinheiro, Cintia R.
   Santos-Silva, Ana Paula
   de Oliveira, Elaine
   Lisboa, Patricia C.
TI Bromocriptine treatment at the end of lactation prevents hyperphagia,
   higher visceral fat and liver triglycerides in early-weaned rats at
   adulthood
SO CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
LA English
DT Article
DE bromocriptine; early weaning; lactation; programming; rats
ID PROLACTIN INHIBITION; METABOLIC SYNDROME; LEPTIN RESISTANCE; OXIDATIVE
   STRESS; OBESITY; PREGNANCY; PROGRAMS; SUPPLEMENTATION; DEPRIVATION;
   DISORDERS
AB Non-pharmacological early weaning (NPEW) leads offspring to obesity, higher liver oxidative stress and microsteatosis in adulthood. Pharmacological EW (PEW) by maternal treatment with bromocriptine (BRO) causes obesity in the adult progeny but precludes hepatic injury. To test the hypothesis that BRO prevents the deleterious changes of NPEW, we injected BRO into the pups from the NPEW model in late lactation. Lactating rats were divided into two groups: dams with an adhesive bandage around the body to prevent breastfeeding on the last 3days of lactation and dams whose pups had free suckling (C). Offspring from both groups were subdivided into two groups: pups treated with BRO (intraperitoneal (i.p.) 4mg/kg per day) on the last 3days of lactation (NPEW/BRO and C/BRO) or pups treated with the vehicle (NPEW and C). At PN120, offspring were challenged with a high fat diet (HFD), and food intake was recorded after 30minutes and 12hours. Rats were killed at PN120 and PN200. At PN120, adipocyte size was greater in the NPEW group but was normal in the NPEW/BRO group. At PN200, the NPEW group presented hyperphagia, higher adiposity, adipocyte hypertrophy, hyperleptinaemia, glucose intolerance and increased hepatic triglycerides. These parameters were normalized in the NPEW/BRO group. In the feeding test, BRO groups showed lower HFD intake at 30minutes than did their controls; however, at 12hours, the NPEW group ate more HFD. The treatment with BRO can preclude some deleterious effects of the NPEW model, which prevented the development of overweight and its comorbidities.
C1 [Peixoto-Silva, Nayara; Moura, Egberto G.; Carvalho, Janaine C.; Nobre, Jessica L.; Quitete, Fernanda T.; Pinheiro, Cintia R.; Santos-Silva, Ana Paula; de Oliveira, Elaine; Lisboa, Patricia C.] Univ Estado Rio De Janeiro, Roberto Alcantara Gomes Biol Inst, Dept Physiol Sci, Lab Endocrine Physiol, Rio De Janeiro, RJ, Brazil.
C3 Universidade do Estado do Rio de Janeiro
RP Lisboa, PC (corresponding author), Univ Estado Rio de Janeiro, Inst Biol, Dept Ciencias Fisiol, 5 Andar, Rio De Janeiro, RJ, Brazil.
EM pclisboa@uerj.br
RI Peixoto-Silva, Nayara/P-5072-2015; Moura, Egberto/H-1270-2012; Lisboa,
   Patricia/H-8336-2015
OI Moura, Egberto/0000-0002-1159-7549; Quitete,
   Fernanda/0000-0003-1747-9954; Lisboa, Patricia/0000-0002-2477-4364
FU Conselho Nacional de Desenvolvimento Cientifico e Tecnologico-CNPq
   (National Council for Scientific and Technological Development);
   Fundacao Carlos Chagas Filho de Amparo a Pesquisa do Estado do Rio de
   Janeiro-FAPERJ (Carlos Chagas Filho Research Foundation of the State of
   Rio de Janeiro); Coordenacao de Aperfeicoamento de Pessoal de Nivel
   Superior-CAPES (Coordination for the Enhancement of Higher Education
   Personnel)
FX Conselho Nacional de Desenvolvimento Cientifico e Tecnologico-CNPq
   (National Council for Scientific and Technological Development);
   Fundacao Carlos Chagas Filho de Amparo a Pesquisa do Estado do Rio de
   Janeiro-FAPERJ (Carlos Chagas Filho Research Foundation of the State of
   Rio de Janeiro); Coordenacao de Aperfeicoamento de Pessoal de Nivel
   Superior-CAPES (Coordination for the Enhancement of Higher Education
   Personnel)
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NR 50
TC 7
Z9 7
U1 0
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1440-1681
J9 CLIN EXP PHARMACOL P
JI Clin. Exp. Pharmacol. Physiol.
PD APR
PY 2017
VL 44
IS 4
BP 488
EP 499
DI 10.1111/1440-1681.12724
PG 12
WC Pharmacology & Pharmacy; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Physiology
GA ER2CL
UT WOS:000398601500007
PM 28058732
DA 2025-06-11
ER

PT J
AU Li, N
   Liao, YL
   Huang, HP
   Fu, SN
AF Li, Ning
   Liao, Yilie
   Huang, Haipeng
   Fu, Suneng
TI Co-regulation of hepatic steatosis by ferritinophagy and unsaturated
   fatty acid supply
SO HEPATOLOGY COMMUNICATIONS
LA English
DT Article
ID ENDOPLASMIC-RETICULUM STRESS; IRON HOMEOSTASIS; NONALCOHOLIC
   STEATOHEPATITIS; OVERWEIGHT CHILDREN; OXIDATIVE STRESS; DEGRADATION;
   HEPCIDIN; OBESITY; FERROPTOSIS; AUTOPHAGY
AB Both iron overload and iron deficiency have been reported in obesity and metabolic syndromes. Due to the presence of multiple intracellular iron pools and the dynamic nature of iron mobilization and use, the actual status and contribution of free and metabolically active iron toward metabolic syndrome remain to be established. The discovery of nuclear receptor coactivator 4 (NCOA4) as a ferritinophagy receptor provides an opening to address the connection between iron and metabolic diseases. This study aims to specifically dissect the role of hepatic ferritinophagy in lipid metabolism and hepatic steatosis. We conducted a series of Ncoa4 gain- and loss-of-function experiments to examine how ferritinophagy affects lipid metabolism through phenotypic and lipidomic analyses both in vitro and in vivo. We show that ferritinophagy is required to release iron from ferritin cages for biological use, and is induced by lipid loading in vitro and during the development of obesity in vivo. Ncoa4 knockdown impairs mitochondrial morphology and reduces palmitate-induced lipid droplet formation in cultured cells and the development of hepatic steatosis in obese mice models. Importantly, the effect of Ncoa4 deficiency on mitochondrial morphology and lipid accumulation is specifically linked to lipidomic reductions in unsaturated fatty acid content in triglycerides and cardiolipins, and an external supply of unsaturated fatty acids reverses these phenotypes. Conclusion: This study shows that ferritinophagy-derived iron supports fatty acid desaturation and the synthesis of unsaturated fatty acid-rich lipids to reduce lipotoxicity. However, the continuous activation of ferritinophagy contributes to the development of hepatic steatosis and liver damage in obesity.
C1 [Li, Ning; Liao, Yilie; Huang, Haipeng] Tsinghua Univ, Sch Life Sci, Beijing, Peoples R China.
   [Fu, Suneng] Guangzhou Lab, Dept Basic Res, Guangzhou 510005, Guangdong, Peoples R China.
C3 Tsinghua University; Guangzhou Laboratory
RP Fu, SN (corresponding author), Guangzhou Lab, Dept Basic Res, Guangzhou 510005, Guangdong, Peoples R China.; Li, N (corresponding author), Tsinghua Univ, Sch Med, 30 Shuanqing Rd, Beijing 100084, Peoples R China.
EM lining201391@163.com; fu_suneng@gzlab.ac.cn
RI Liao, Yilie/NHP-4846-2025; Huang, Haipeng/MFJ-4203-2025
OI Huang, Haipeng/0000-0001-5525-6845
FU National Key Research and Development Program of China [2016YFA0502002,
   2017YFA0504603]; National Natural Science Foundation of China [31671229,
   81471072]; Guangzhou Laboratory; Tsinghua-Peking Center for Life
   Sciences
FX National Key Research and Development Program of China, Grant/Award
   Number: 2016YFA0502002 and 2017YFA0504603; National Natural Science
   Foundation of China, Grant/Award Number: 31671229 and 81471072;
   Tsinghua-Peking Center for Life Sciences; Guangzhou Laboratory
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NR 49
TC 4
Z9 4
U1 1
U2 12
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
EI 2471-254X
J9 HEPATOL COMMUN
JI Hepatol. Commun.
PD OCT
PY 2022
VL 6
IS 10
BP 2640
EP 2653
DI 10.1002/hep4.2040
EA JUL 2022
PG 14
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 4V0ZE
UT WOS:000828146500001
PM 35861547
OA Green Published
DA 2025-06-11
ER

PT J
AU Al-kuraishy, HM
   Al-Gareeb, A
   El-Bouseary, MM
   Sonbol, F
   Batiha, GES
AF Al-kuraishy, Hayder M.
   Al-Gareeb, Ali, I
   El-Bouseary, Maisra M.
   Sonbol, Fatma, I
   Batiha, Gaber El-Saber
TI Hyperviscosity syndrome in COVID-19 and related vaccines: exploring of
   uncertainties
SO CLINICAL AND EXPERIMENTAL MEDICINE
LA English
DT Review
DE COVID-19; Hyperviscosity syndrome; COVID-19 vaccination
ID WHOLE-BLOOD VISCOSITY; HIGH-DENSITY-LIPOPROTEIN; MICROCIRCULATORY
   DYSFUNCTION; SYNDROME SECONDARY; OXIDATIVE STRESS; PLASMA; FIBRINOGEN;
   DISEASE; RISK; COAGULATION
AB Hyperviscosity syndrome (HVS) recently emerged as a complication of coronavirus disease 2019 (COVID-19) and COVID-19 vaccines. Therefore, the objectives of this critical review are to establish the association between COVID-19 and COVID-19 vaccines with the development of HVS. HVS may develop in various viral infections due to impairment of humoral and cellular immunity with elevation of immunoglobulins. COVID-19 can increase blood viscosity (BV) through modulation of fibrinogen, albumin, lipoproteins, and red blood cell (RBC) indices. HVS can cause cardiovascular and neurological complications in COVID-19 like myocardial infarction (MI) and stroke. HVS with or without abnormal RBCs function in COVID-19 participates in the reduction of tissue oxygenation with the development of cardio-metabolic complications and long COVID-19. Besides, HVS may develop in vaccine recipients with previous COVID-19 due to higher underlying Ig concentrations and rarely without previous COVID-19. Similarly, patients with metabolic syndrome are at the highest risk for propagation of HVS after COVID-19 vaccination. In conclusion, COVID-19 and related vaccines are linked with the development of HVS, mainly in patients with previous COVID-19 and underlying metabolic derangements. The possible mechanism of HVS in COVID-19 and related vaccines is increasing levels of fibrinogen and immunoglobulins. However, dehydration, oxidative stress, and inflammatory reactions are regarded as additional contributing factors in the pathogenesis of HVS in COVID-19. However, this critical review cannot determine the final causal relationship between COVID-19 and related vaccines and the development of HVS. Prospective and retrospective studies are warranted in this field.
C1 [Al-kuraishy, Hayder M.; Al-Gareeb, Ali, I] Al Mustansiriya Univ, Coll Med, Dept Clin Pharmacol & Med, Baghdad, Iraq.
   [El-Bouseary, Maisra M.; Sonbol, Fatma, I] Tanta Univ, Fac Pharm, Dept Pharmaceut Microbiol, Tanta, Egypt.
   [Batiha, Gaber El-Saber] Damanhour Univ, Fac Vet Med, Dept Pharmacol & Therapeut, Damanhour 22511, Albeheira, Egypt.
C3 Mustansiriya University; Egyptian Knowledge Bank (EKB); Tanta
   University; Egyptian Knowledge Bank (EKB); Damanhour University
RP El-Bouseary, MM (corresponding author), Tanta Univ, Fac Pharm, Dept Pharmaceut Microbiol, Tanta, Egypt.; Batiha, GES (corresponding author), Damanhour Univ, Fac Vet Med, Dept Pharmacol & Therapeut, Damanhour 22511, Albeheira, Egypt.
EM Hayderm36@yahoo.com; maysra_mohamed@pharm.tanta.edu.eg;
   gaberbatiha@gmail.com
RI al-kuraishy, hayder/AAE-6673-2019; Al-Gareeb, Ali/I-8330-2019
OI Al-Gareeb, Ali/0000-0001-8284-8897; El-Bouseary,
   Maisra/0000-0001-6503-0719
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NR 99
TC 18
Z9 18
U1 0
U2 28
PU SPRINGER-VERLAG ITALIA SRL
PI MILAN
PA VIA DECEMBRIO, 28, MILAN, 20137, ITALY
SN 1591-8890
EI 1591-9528
J9 CLIN EXP MED
JI Clin. Exper. Med.
PD JUL
PY 2023
VL 23
IS 3
BP 679
EP 688
DI 10.1007/s10238-022-00836-x
EA MAY 2022
PG 10
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA K6KU9
UT WOS:000801086300001
PM 35608715
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Horn, CL
   Morales, AL
   Savard, C
   Farrell, GC
   Ioannou, GN
AF Horn, Christian L.
   Morales, Amilcar L.
   Savard, Christopher
   Farrell, Geoffrey C.
   Ioannou, George N.
TI Role of Cholesterol-Associated Steatohepatitis in the Development of
   NASH
SO HEPATOLOGY COMMUNICATIONS
LA English
DT Review
ID NONALCOHOLIC FATTY LIVER; ENDOPLASMIC-RETICULUM STRESS;
   LOW-DENSITY-LIPOPROTEIN; HEPATIC STELLATE CELLS; CORONARY-HEART-DISEASE;
   CROWN-LIKE STRUCTURES; NUCLEAR RECEPTOR FXR; FARNESOID-X-RECEPTOR;
   DIETARY-CHOLESTEROL; METABOLIC SYNDROME
AB The rising prevalence of nonalcoholic fatty liver disease (NAFLD) and NAFLD-related cirrhosis in the United States and globally highlights the need to better understand the mechanisms causing progression of hepatic steatosis to fibrosing steatohepatitis and cirrhosis in a small proportion of patients with NAFLD. Accumulating evidence suggests that lipotoxicity mediated by hepatic free cholesterol (FC) overload is a mechanistic driver for necroinflammation and fibrosis, characteristic of nonalcoholic steatohepatitis (NASH), in many animal models and also in some patients with NASH. Diet, lifestyle, obesity, key genetic polymorphisms, and hyperinsulinemia secondary to insulin resistance are pivotal drivers leading to aberrant cholesterol signaling, which leads to accumulation of FC within hepatocytes. FC overload in hepatocytes can lead to ER stress, mitochondrial dysfunction, development of toxic oxysterols, and cholesterol crystallization in lipid droplets, which in turn lead to hepatocyte apoptosis, necrosis, or pyroptosis. Activation of Kupffer cells and hepatic stellate cells by hepatocyte signaling and cholesterol loading contributes to this inflammation and leads to hepatic fibrosis. Cholesterol accumulation in hepatocytes can be readily prevented or reversed by statins. Observational studies suggest that use of statins in NASH not only decreases the substantially increased cardiovascular risk, but may ameliorate liver pathology. Conclusion: Hepatic FC loading may result in cholesterol-associated steatohepatitis and play an important role in the development and progression of NASH. Statins appear to provide significant benefit in preventing progression to NASH and NASH-cirrhosis. Randomized controlled trials are needed to demonstrate whether statins or statin/ezetimibe combination can effectively reverse steatohepatitis and liver fibrosis in patients with NASH.
C1 [Horn, Christian L.; Morales, Amilcar L.] San Antonio Mil Med Ctr, Dept Med, Div Gastroenterol & Hepatol, Ft Sam Houston, TX USA.
   [Savard, Christopher; Ioannou, George N.] Vet Affairs Puget Sound Hlth Care Syst, Dept Med, Div Gastroenterol, Seattle, WA USA.
   [Savard, Christopher; Ioannou, George N.] Univ Washington, Dept Med, Div Gastroenterol, Seattle, WA USA.
   [Savard, Christopher; Ioannou, George N.] Vet Affairs Puget Sound Hlth Care Syst, Res & Dev, Seattle, WA USA.
   [Farrell, Geoffrey C.] Australian Natl Univ, Canberra Hosp, ANU Med Sch, Liver Res Grp, Garran, ACT, Australia.
C3 San Antonio Military Medical Center; US Department of Veterans Affairs;
   Veterans Health Administration (VHA); Vet Affairs Puget Sound Health
   Care System; University of Washington; University of Washington Seattle;
   US Department of Veterans Affairs; Veterans Health Administration (VHA);
   Vet Affairs Puget Sound Health Care System; Australian National
   University; Canberra Hospital
RP Ioannou, GN (corresponding author), Vet Affairs Puget Sound Healthcare Syst, Gastroenterol, S-111-GI,1660 S Columbian Way, Seattle, WA 98108 USA.
EM georgei@medicine.washington.edu
OI Horn, Christian/0000-0002-3948-5100
FU U.S. Department of Veterans Affairs [BX002910]
FX d Supported by the U.S. Department of Veterans Affairs (BX002910).
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NR 179
TC 128
Z9 131
U1 7
U2 38
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
EI 2471-254X
J9 HEPATOL COMMUN
JI Hepatol. Commun.
PD JAN
PY 2022
VL 6
IS 1
BP 12
EP 35
DI 10.1002/hep4.1801
EA AUG 2021
PG 24
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA XU6ME
UT WOS:000687652700001
PM 34558856
OA Green Published, gold
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Kuvat, N
   Tanriverdi, H
   Armutcu, F
AF Kuvat, Nuray
   Tanriverdi, Hakan
   Armutcu, Ferah
TI The relationship between obstructive sleep apnea syndrome and obesity: A
   new perspective on the pathogenesis in terms of organ crosstalk
SO CLINICAL RESPIRATORY JOURNAL
LA English
DT Review
DE gut microbiota; inflammation; metabolic dysregulation; obesity;
   obstructive sleep apnoea; organ cross-talk
ID ADIPOSE-TISSUE DYSFUNCTION; BODY-FAT DISTRIBUTION; GUT MICROBIOTA;
   OXIDATIVE STRESS; CARDIOVASCULAR-DISEASE; INSULIN-RESISTANCE; METABOLIC
   SYNDROME; INTERMITTENT HYPOXIA; INFLAMMATION; LEPTIN
AB Introduction Obstructive sleep apnea syndrome (OSAS) is a common disorder that has a major impact on public health. The connection between OSAS and obesity is very complex and likely represents an interaction between biological and lifestyle factors. Oxidative stress, inflammation and metabolic dysregulation are both actors involved in the pathogenesis of OSAS and obesity. Also, the current evidence suggests that gut microbiota plays a significant role in the emergence and progression of some metabolic disorders. When the relationship between OSAS and obesity is evaluated extensively, it is understood that they show mutual causality with each other, and that metabolic challenges such as impaired microbiota affect this bidirectional organ interaction, and by ensuing organ injury. Objectives The aim of this study is to investigate the association between OSAS and obesity, and the effect of "organ crosstalk" on the pathogenesis of the relationship and to contribute to the diagnosis and treatment options in the light of current data. Data Source We performed an electronic database search including PubMed, EMBASE and Web of Science. We used the following search terms: OSAS, obesity, inflammation, metabolic dysregulation and gut microbiota. Conclusion Obesity and OSAS adversely affect many organs and systems. Besides the factors affecting the diagnosis of the OSAS-obesity relationship, mutual organ interactions among the respiratory system, adipose tissue and intestines should not be ignored for prevention and treatment of OSAS and obesity. Comprehensive clinical trials addressing the efficacy and efficiency of current or potential treatments on therapeutic applications in the OSAS-obesity relationship are needed.
C1 [Kuvat, Nuray] Haseki Training & Res Hosp, Infect Dis & Clin Microbiol, Istanbul, Turkey.
   [Tanriverdi, Hakan] Bulent Ecevit Univ, Fac Med, Dept Chest Dis, Zonguldak, Turkey.
   [Armutcu, Ferah] Istanbul Univ, Cerrahpasa Med Fac, Dept Biochem, Istanbul, Turkey.
C3 Istanbul Haseki Training & Research Hospital; Zonguldak Bulent Ecevit
   University; Istanbul University - Cerrahpasa; Istanbul University
RP Armutcu, F (corresponding author), Istanbul Univ, Cerrahpasa Med Fac, Dept Biochem, Istanbul, Turkey.
EM drferah@gmail.com
RI TANRIVERDİ, HAKAN/GQA-4925-2022
OI Armutcu, Ferah/0000-0002-3218-9480
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PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1752-6981
EI 1752-699X
J9 CLIN RESPIR J
JI Clin. Respir. J.
PD JUL
PY 2020
VL 14
IS 7
BP 595
EP 604
DI 10.1111/crj.13175
PG 10
WC Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Respiratory System
GA ME3MM
UT WOS:000544563200001
PM 32112481
OA Bronze
DA 2025-06-11
ER

PT J
AU Kovacevic, L
   Lu, H
   Caruso, JA
   Kovacevic, N
   Lakshmanan, Y
AF Kovacevic, Larisa
   Lu, Hong
   Caruso, Joseph A.
   Kovacevic, Natalija
   Lakshmanan, Yegappan
TI Urinary proteomics reveals association between pediatric nephrolithiasis
   and cardiovascular disease
SO INTERNATIONAL UROLOGY AND NEPHROLOGY
LA English
DT Article
DE Nephrolithiasis; Cardiovascular disease; Proteomics; Children
ID CELL-ADHESION MOLECULE-1; CORONARY-HEART-DISEASE; KIDNEY-STONES;
   METABOLIC SYNDROME; RISK; ATHEROSCLEROSIS; PREVALENCE; MECHANISMS;
   DATABASE; BONE
AB PurposeTo study (1) the differences in the relative abundance of urinary proteins between children with kidney stones (RS) and hypercalciuria, hypocitraturia, normal metabolic work-up, and healthy controls (HC); (2) the association of these proteins with various diseases.MethodsQuantitative proteomic comparison of pooled urine from RS (N=30, 24 females, mean age 12.954.03years) versus age- and gender-matched HC, using mass spectrometry. Relative protein abundance was estimated using spectral counting. Proteins of interest were selected using the following criteria: (1) 5 spectral counts; (2) twofold difference in spectral counts; and (3) 0.05 p value for the Fisher's Exact Test.ResultsOf the 1813 proteins identified, 229 met the above criteria, with 162 proteins up-regulated in the RS group and 67 up-regulated in HC. The largest group of proteins (30 out of 229) was found to be associated with cardiovascular disease (CVD). Of those, 16 were involved in coagulation, fibrinolysis, and adhesion, 10 in inflammation, 5 in lipid transport and metabolism, and 4 in oxidative stress. All except two were exclusively found in children with hypercalciuria and hypocitraturia, and were not seen in children with normal metabolic work-up.Conclusion Using a proteomic approach, we found a significant association between hypercalciuric and hypocitraturic nephrolithiasis and CVD in children. The shared risk factors among both diseases are endothelial dysfunction and atherosclerosis caused by abnormal coagulation, adhesion, disturbance of lipid transport and metabolism, oxidative stress and inflammation. Further understanding of the pathophysiological link between nephrolithiasis and CVD is necessary for developing new therapeutic targets.
C1 [Kovacevic, Larisa; Lu, Hong; Kovacevic, Natalija; Lakshmanan, Yegappan] Childrens Hosp Michigan, Dept Pediat Urol, 3901 Beaubien Blvd, Detroit, MI 48201 USA.
   [Caruso, Joseph A.] Wayne State Univ, Inst Environm Hlth Sci, Detroit, MI USA.
   [Kovacevic, Natalija] Henri Ford Hosp, Vattikuti Urol Inst, Detroit, MI USA.
C3 Children's Hospital of Michigan; Wayne State University; Henry Ford
   Health System; Henry Ford Hospital
RP Kovacevic, L (corresponding author), Childrens Hosp Michigan, Dept Pediat Urol, 3901 Beaubien Blvd, Detroit, MI 48201 USA.
EM lkovacev@dmc.org
RI Caruso, Joseph/U-8429-2019
FU Children's Hospital of Michigan Foundation [R2-2014-31]; NIH Center
   Grant [P30 ES 020957]; NIH Cancer Center Support Grant [P30 CA 022453];
   NIH Shared Instrumentation Grant [S10 OD 010700]
FX This study was funded by Children's Hospital of Michigan Foundation
   (R2-2014-31), NIH Center Grant (P30 ES 020957), NIH Cancer Center
   Support Grant (P30 CA 022453) and NIH Shared Instrumentation Grant (S10
   OD 010700).
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NR 30
TC 11
Z9 11
U1 0
U2 3
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0301-1623
EI 1573-2584
J9 INT UROL NEPHROL
JI Int. Urol. Nephrol.
PD NOV
PY 2018
VL 50
IS 11
BP 1949
EP 1954
DI 10.1007/s11255-018-1976-9
PG 6
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA GY7QF
UT WOS:000448806900003
PM 30209738
DA 2025-06-11
ER

PT J
AU Rezania, S
   Puskarich, MA
   Petrusca, DN
   Neto-Neves, EM
   Rondina, MT
   Kline, JA
AF Rezania, Samin
   Puskarich, Michael A.
   Petrusca, Daniela N.
   Neto-Neves, Evandro M.
   Rondina, Matthew T.
   Kline, Jeffrey A.
TI Platelet hyperactivation, apoptosis and hypercoagulability in patients
   with acute pulmonary embolism
SO THROMBOSIS RESEARCH
LA English
DT Article
DE Apoptosis; Oxidative stress; Platelet; Thromboembolism
ID CYTOCHROME-C RELEASE; DISSEMINATED INTRAVASCULAR COAGULATION; TRANSIENT
   ISCHEMIC ATTACK; VENOUS THROMBOEMBOLISM; MITOCHONDRIAL DYSFUNCTION;
   CASPASE-3 ACTIVATION; METABOLIC SYNDROME; EARLY DEATH; MICROPARTICLES;
   CELLS
AB Changes in systemic redox balance can alter platelet activation and aggregation. Acute pulmonary embolism (PE) is a systematic inflammatory disease associated with mechanical shear stress, increased thrombin, catechol-amines, serotonin and hemolysis, which cumulatively can hyperactivate platelets and accelerate their turnover. We tested the hypothesis that platelets from patients with moderately severe PE will show hyperstimulation and a pre-apoptotic phenotype associated with microparticles (MPs) in plasma. Blood for platelet respiration and thromboelastography (TEG) was obtained at diagnosis and 24 h later from patients (n = 76) with image-proven PE, SBP > 90 mm Hg and right ventricular dysfunction demonstrated by echocardiogram or elevated biomarkers. Controls (n = 12) were healthy volunteers. At diagnosis, platelets from PE patients had significantly elevated baseline oxygen consumption compared with controls, explained primarily by accelerated electron transport and oxygen wasting with no measurable extramitochondrial oxygen consumption. On thromboelastography, unstimulated thrombin-independent maximum amplitude was increased with PE, 19 +/- 14.1 vs. 10.5 +/- 7.8 mm in controls (p = 0.002). Compared with controls, platelets from PE patients showed elevated mitochondrial reactive oxygen species with decreased mitochondrial Bcl-2 protein content and increased cytosolic cytochrome C, coincident with strong annexin V binding, P selectin release from lysed platelets and in plasma MPs compared to controls (p < 0.05).
   These results show evidence of platelet hyperactivation and apoptosis in patients with acute PE, and provide preliminary theoretical basis for further exploration of platelet inhibition in patients with more severe PE. (C) 2017 Elsevier Ltd. All rights reserved.
C1 [Rezania, Samin; Neto-Neves, Evandro M.; Kline, Jeffrey A.] Indiana Univ Sch Med, Dept Emergency Med, 720 Eskenazi Ave, Indianapolis, IN 46202 USA.
   [Puskarich, Michael A.] Univ Mississippi, Med Ctr, Dept Emergency Med, Jackson, MS 39216 USA.
   [Petrusca, Daniela N.] Indiana Univ Sch Med, Dept Hematol Oncol, Indianapolis, IN 46202 USA.
   [Rondina, Matthew T.] Univ Utah Hlth Care, Dept Med, Salt Lake City, UT USA.
C3 Indiana University System; Indiana University Bloomington; University of
   Mississippi; University of Mississippi Medical Center; Indiana
   University System; Indiana University Bloomington; Utah System of Higher
   Education; University of Utah; University of Utah Hospital
RP Kline, JA (corresponding author), Indiana Univ Sch Med, Dept Emergency Med, 720 Eskenazi Ave, Indianapolis, IN 46202 USA.; Kline, JA (corresponding author), Indiana Univ Sch Med, Dept Cellular & Integrat Physiol, 720 Eskenazi Ave, Indianapolis, IN 46202 USA.
EM jefkline@iupui.edu
RI NETO-NEVES, EVANDRO/ABF-6705-2020; NETO-NEVES, EVANDRO/V-6240-2018;
   Puskarich, Michael/N-7849-2014
OI NETO-NEVES, EVANDRO/0000-0002-5450-9326; Puskarich,
   Michael/0000-0001-6358-4670
FU NHLBI A1 [UM1HL113203-01]; Mallingkrodt; Lilly Foundation Physician
   Scientist Initiative
FX UM1HL113203-01 NHLBI A1, Mallingkrodt, and the Lilly Foundation
   Physician Scientist Initiative to JAK.
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NR 61
TC 24
Z9 24
U1 2
U2 9
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0049-3848
J9 THROMB RES
JI Thromb. Res.
PD JUL
PY 2017
VL 155
BP 106
EP 115
DI 10.1016/j.thromres.2017.05.009
PG 10
WC Hematology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Hematology; Cardiovascular System & Cardiology
GA FA8FO
UT WOS:000405681800019
PM 28528289
DA 2025-06-11
ER

PT J
AU Sohn, M
   Kim, K
   Uddin, MJ
   Lee, G
   Hwang, I
   Kang, H
   Kim, H
   Lee, JH
   Ha, H
AF Sohn, Minji
   Kim, Keumji
   Uddin, Md Jamal
   Lee, Gayoung
   Hwang, Inah
   Kang, Hyeji
   Kim, Hyunji
   Lee, Jung Hwa
   Ha, Hunjoo
TI Delayed treatment with fenofibrate protects against high-fat
   diet-induced kidney injury in mice: the possible role of AMPK autophagy
SO AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
LA English
DT Article
DE AMPK; autophagy; fenofibrate; high-fat diet; kidney injury
ID RENAL INJURY; THERAPEUTIC STRATEGY; HEPATIC INFLAMMATION;
   LIPID-ACCUMULATION; METABOLIC SYNDROME; KINASE ACTIVATION; OXIDATIVE
   STRESS; PROXIMAL TUBULE; PATHWAY; DISEASE
AB Fenofibrate activates not only peroxisome proliferator-activated receptor-alpha (PPAR alpha) but also adenosine monophosphate-activated protein kinase (AMPK). AMPK-mediated cellular responses protect kidney from high-fat diet (HFD)-induced injury, and autophagy resulting from AMPK activation has been regarded as a stress-response mechanism. Thus the present study examined the role of AMPK and autophagy in the renotherapeutic effects of fenofibrate. C57BL/6J mice were divided into three groups: normal diet (ND), HFD, and HFD + fenofibrate (HFD + FF). Fenofibrate was administered 4 wk after the initiation of the HFD when renal injury was initiated. Mouse proximal tubule cells (mProx24) were used to clarify the role of AMPK. Feeding mice with HFD for 12 wk induced insulin resistance and kidney injury such as albuminuria, glomerulosclerosis, tubular injury, and inflammation, which were effectively inhibited by fenofibrate. In addition, fenofibrate treatment resulted in the activation of renal AMPK, upregulation of fatty acid oxidation (FAO) enzymes and antioxidants, and induction of autophagy in the HFD mice. In mProx24 cells, fenofibrate activated AMPK in a concentration-dependent manner, upregulated FAO enzymes and antioxidants, and induced autophagy, all of which were inhibited by treatment of compound C, an AMPK inhibitor. Fenofibrate-induced autophagy was also significantly blocked by AMPK alpha 1 siRNA but not by PPAR alpha siRNA. Collectively, these results demonstrate that delayed treatment with fenofibrate has a therapeutic effect on HFD-induced kidney injury, at least in part, through the activation of AMPK and induction of subsequent downstream effectors: autophagy, FAO enzymes, and antioxidants.
C1 [Sohn, Minji; Kim, Keumji; Uddin, Md Jamal; Lee, Gayoung; Hwang, Inah; Kang, Hyeji; Kim, Hyunji; Lee, Jung Hwa; Ha, Hunjoo] Ewha Womans Univ, Coll Pharm, Grad Sch Pharmaceut Sci, 52 Ewhayeodae Gil, Seoul 120750, South Korea.
C3 Ewha Womans University
RP Ha, H (corresponding author), Ewha Womans Univ, Coll Pharm, Grad Sch Pharmaceut Sci, 52 Ewhayeodae Gil, Seoul 120750, South Korea.
EM hha@ewha.ac.kr
RI Uddin, Md Jamal/W-3434-2017; Hwang, Inah/AAZ-5420-2021
OI Ha, Hunjoo/0000-0002-5601-1265; Uddin, Md Jamal/0000-0003-2911-3255;
   Hwang, Inah/0000-0002-4479-9374
FU National Research Foundation - Korean Ministry of Education, Science,
   and Technology [2012R1A2A1A0300692, 2016R1A2B4006575, 2015H1D3A1062189]
FX This work is supported by National Research Foundation Grants
   2012R1A2A1A0300692, 2016R1A2B4006575, and 2015H1D3A1062189 funded by
   Korean Ministry of Education, Science, and Technology.
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NR 47
TC 63
Z9 63
U1 0
U2 17
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 1931-857X
EI 1522-1466
J9 AM J PHYSIOL-RENAL
JI Am. J. Physiol.-Renal Physiol.
PD FEB 1
PY 2017
VL 312
IS 2
BP F323
EP F334
DI 10.1152/ajprenal.00596.2015
PG 12
WC Physiology; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology; Urology & Nephrology
GA EK4LJ
UT WOS:000393897900012
PM 27465995
DA 2025-06-11
ER

PT J
AU Duivenvoorde, LPM
   van Schothorst, EM
   Derous, D
   van der Stelt, I
   Masania, J
   Rabbani, N
   Thornalley, PJ
   Keijer, J
AF Duivenvoorde, Loes P. M.
   van Schothorst, Evert M.
   Derous, Davina
   van der Stelt, Inge
   Masania, Jinit
   Rabbani, Naila
   Thornalley, Paul J.
   Keijer, Jaap
TI Oxygen restriction as challenge test reveals early high-fat-diet-induced
   changes in glucose and lipid metabolism
SO PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
LA English
DT Article
DE Hypoxia; Metabolism; High-fat diet; Obesity; Oxidative stress; Indirect
   calorimetry
ID ADIPOSE-TISSUE; GENE-EXPRESSION; INTERMITTENT HYPOXIA;
   ENERGY-EXPENDITURE; INSULIN-RESISTANCE; TRANSCRIPTIONAL REGULATION;
   MASS-SPECTROMETRY; MICE; OBESITY; OXIDATION
AB Challenge tests stress homeostasis and may reveal deviations in health that remain masked under unchallenged conditions. Ideally, challenge tests are non-invasive and applicable in an early phase of an animal experiment. Oxygen restriction (OxR; based on ambient, mild normobaric hypoxia) is a non-invasive challenge test that measures the flexibility to adapt metabolism. Metabolic inflexibility is one of the hallmarks of the metabolic syndrome. To test whether OxR can be used to reveal early diet-induced health effects, we exposed mice to a low-fat (LF) or high-fat (HF) diet for only 5 days. The response to OxR was assessed by calorimetric measurements, followed by analysis of gene expression in liver and epididymal white adipose tissue (eWAT) and serum markers for e.g. protein glycation and oxidation. Although HF feeding increased body weight, HF and LF mice did not differ in indirect calorimetric values under normoxic conditions and in a fasting state. Exposure to OxR; however, increased oxygen consumption and lipid oxidation in HF mice versus LF mice. Furthermore, OxR induced gluconeogenesis and an antioxidant response in the liver of HF mice, whereas it induced de novo lipogenesis and an antioxidant response in eWAT of LF mice, indicating that HF and LF mice differed in their adaptation to OxR. OxR also increased serum markers of protein glycation and oxidation in HF mice, whereas these changes were absent in LF mice. Cumulatively, OxR is a promising new method to test food products on potential beneficial effects for human health.
C1 [Duivenvoorde, Loes P. M.; van Schothorst, Evert M.; Derous, Davina; van der Stelt, Inge; Keijer, Jaap] Wageningen Univ, Human & Anim Physiol, NL-6708 WD Wageningen, Netherlands.
   [Masania, Jinit; Rabbani, Naila; Thornalley, Paul J.] Univ Warwick, Univ Hosp, Warwick Med Sch, Clin Sci Res Labs, Coventry CV4 7AL, W Midlands, England.
C3 Wageningen University & Research; University of Warwick
RP Keijer, J (corresponding author), Wageningen Univ, Human & Anim Physiol, De Elst 1, NL-6708 WD Wageningen, Netherlands.
EM jaap.keijer@wur.nl
RI der Grinten, Hedi/L-4247-2015; Derous, Davina/AAH-4740-2020; Keijer,
   Jaap/J-8089-2013
OI Rabbani, Naila/0000-0002-5819-2506; van Schothorst,
   Evert/0000-0002-3036-5903; Derous, Davina/0000-0002-9041-4607; Masania,
   Jinit/0000-0001-8381-2917; Thornalley, Paul/0000-0001-7659-443X; Keijer,
   Jaap/0000-0002-9720-7491
FU European Union [244995]
FX This work was supported by the European Union's Seventh Framework
   Program FP7 2007-2013 under grant agreement no. 244995 (BIOCLAIMS
   Project). Furthermore, we would like to thank all members of Human and
   Animal Physiology for their helpful contributions, especially Hans
   Swarts, Dylan Eikelenboomand Esther Steenbergh for their help during the
   animal experiment and the analysis of gene expression.
CR [Anonymous], CANAD J SPORT SCI
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NR 60
TC 8
Z9 9
U1 0
U2 16
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0031-6768
EI 1432-2013
J9 PFLUG ARCH EUR J PHY
JI Pflugers Arch.
PD JUN
PY 2015
VL 467
IS 6
BP 1179
EP 1193
DI 10.1007/s00424-014-1553-8
PG 15
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA CI3DZ
UT WOS:000354629100003
PM 24974902
DA 2025-06-11
ER

PT J
AU Barbosa, KBF
   Volp, ACP
   Marques-Rocha, JL
   Ribeiro, SMR
   Navarro-Blasco, I
   Zulet, MA
   Martínez, JA
   Bressan, J
AF Ferreira Barbosa, Kiriaque Barra
   Pinheiro Volp, Ana Carolina
   Marques-Rocha, Jose Luiz
   Rocha Ribeiro, Sonia Machado
   Navarro-Blasco, Inigo
   Angeles Zulet, Maria
   Alfredo Martinez, J.
   Bressan, Josefina
TI Low energy and carbohydrate intake associated with higher total
   antioxidant capacity in apparently healthy adults
SO NUTRITION
LA English
DT Article
DE Oxidative stress; Total antioxidant capacity; Dietary intake;
   Biomarkers; Antioxidant assessment
ID OXIDATIVE STRESS MARKERS; LOW-DENSITY-LIPOPROTEIN; VITAMIN-C;
   LIPID-PEROXIDATION; METABOLIC SYNDROME; IN-VIVO; OBESITY; DIET;
   INFLAMMATION; BIOMARKERS
AB Objectives: The aim of this study was to investigate the associations between plasma total antioxidant capacity (TAC) and anthropometric, biochemical, clinical, and dietary measurements in young and apparently healthy individuals.
   Methods: We evaluated 156 individuals (91 women and 65 men; ages 23.1 +/- 3.5 y; body mass index 22 +/- 2.9 kg/m(2)) for anthropometrics, biochemical markers, clinical, dietary, and some components of the antioxidant defense system, including the plasma TAC. Statistical analyses were performed to detect differences between individuals with TAC higher and lower than the mean value and to screen the associations between TAC and variables of interest. A linear regression model was fitted to identify TAC predictors.
   Results: Daily caloric intake and macronutrient consumption were lower in individuals who exhibited the highest TAC values (P < 0.05). Linear regression analysis showed that daily calories and carbohydrate intake was a possible negative TAC predictor (P < 0.05). Nevertheless, there was no difference in the values of oxidized low-density lipoprotein in the individuals separated by means of TAC. In contrast, individuals whose plasma TAC values were above the mean showed higher low-density lipoprotein cholesterol concentrations, total cholesterol/high-density lipoprotein cholesterol values, and selenium in nails (P < 0.05).
   Conclusions: In physiological conditions, the caloric intake level seems to be an important factor to act in the modulation of plasma TAC, before establishing anthropometric impairments of body or metabolic composition, or both. Additionally, the plasma TAC increase may be able to act as a compensatory mechanism. (C) 2014 Elsevier Inc. All rights reserved.
C1 [Ferreira Barbosa, Kiriaque Barra] Univ Fed Sergipe, Nutr Ctr, Aracaju, Brazil.
   [Pinheiro Volp, Ana Carolina] Univ Fed Ouro Preto, Dept Social Clin & Nutr, Ouro Preto, Brazil.
   [Marques-Rocha, Jose Luiz; Rocha Ribeiro, Sonia Machado; Bressan, Josefina] Univ Fed Vicosa, Dept Nutr & Hlth, Vicosa, MG, Brazil.
   [Marques-Rocha, Jose Luiz; Angeles Zulet, Maria; Alfredo Martinez, J.] Univ Navarra, Ctr Nutr Res, Dept Nutr Food Sci & Physiol, E-31080 Pamplona, Spain.
   [Navarro-Blasco, Inigo] Univ Navarra, Dept Chem & Soil Sci, E-31080 Pamplona, Spain.
   [Angeles Zulet, Maria; Alfredo Martinez, J.] Inst Salud Carlos III, CIBERobn, Madrid, Spain.
C3 Universidade Federal de Sergipe; Universidade Federal de Ouro Preto;
   Universidade Federal de Vicosa; University of Navarra; University of
   Navarra; Instituto de Salud Carlos III; CIBER - Centro de Investigacion
   Biomedica en Red; CIBEROBN
RP Martínez, JA (corresponding author), Univ Navarra, Ctr Nutr Res, Dept Nutr Food Sci & Physiol, E-31080 Pamplona, Spain.
EM jalfmtz@unav.es
RI Bressan, Josefina/A-2598-2009; Barbosa, Kiriaque/E-4269-2014; Zulet, M.
   Angeles/H-1317-2017; Martinez Hernandez, J Alfredo/K-8709-2014;
   Navarro-Blasco, Inigo/D-8148-2012
OI Bressan, Josefina/0000-0002-4993-9436; Zulet, M.
   Angeles/0000-0002-3926-0892; Martinez Hernandez, J
   Alfredo/0000-0001-5218-6941; Navarro-Blasco, Inigo/0000-0003-1863-0580;
   Marques-Rocha, Jose Luiz/0000-0002-0783-5807
FU Fundacao de Amparo a Pesquisa do Estado de Minas Gerais (FAPEMIG) [CDS
   303/06]
FX This study was supported by the Fundacao de Amparo a Pesquisa do Estado
   de Minas Gerais (FAPEMIG CDS 303/06). KB-B and AC-V contributed to the
   design and fieldwork, data collection, analysis, and drafting of the
   manuscript. JL-R, SM-R, IN-B, and MA-Z were involved in the design and
   the fieldwork as well as in the critical reading of the manuscript. JB
   was responsible for general coordination, follow-up, design, financial
   management, and the editing of the manuscript. JAM was a co-leader of
   the project and was responsible for follow-up, design, financial
   management, and editing of the manuscript. All of the authors actively
   participated in manuscript preparation, and all read and approved the
   final manuscript.
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NR 71
TC 12
Z9 12
U1 0
U2 8
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0899-9007
EI 1873-1244
J9 NUTRITION
JI Nutrition
PD NOV-DEC
PY 2014
VL 30
IS 11-12
BP 1349
EP 1354
DI 10.1016/j.nut.2014.03.031
PG 6
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA AQ7AE
UT WOS:000342964200017
PM 25280411
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Karlamangla, AS
   Singer, BH
   McEwen, BS
   Rowe, JW
   Seeman, TE
AF Karlamangla, AS
   Singer, BH
   McEwen, BS
   Rowe, JW
   Seeman, TE
TI Allostatic load as a predictor of functional decline MacArthur studies
   of successful aging
SO JOURNAL OF CLINICAL EPIDEMIOLOGY
LA English
DT Article
DE physiologic dysregulation; allostatic load; functional decline;
   canonical correlation; bootstrapping; stress hormones
ID ISCHEMIC-HEART-DISEASE; RISK-FACTORS; CORTISOL-LEVELS;
   DEHYDROEPIANDROSTERONE-SULFATE; METABOLIC SYNDROME; PHYSICAL-ACTIVITY;
   STRESS; HEALTH; MORTALITY; WOMEN
AB Allostatic load has been proposed as a cumulative measure of dysregulation across multiple physiological systems, and has been postulated to impact health risks. In the allostatic load model, increased risk is hypothesized to result not only from large and clinically significant dysregulation in individual systems, but also from more modest dysregulation, if present in multiple systems. Our objective was to construct an allostatic load score by optimally combining several physiologic measurements, and to examine its association with future functional decline. We analyzed data from a 7-year longitudinal study of a community-based cohort, whose age at baseline was between 70 and 79 cars. Canonical correlation analysis was used to study the association of 10 biological measurements representing allostatic load with declines in scores tin five tests each of physical and cognitive function over two follow-up periods: 1998-1991 and 1991-1995. We used bootstrapping to evaluate the stability of the canonical Correlation and canonical weights. The canonical correlation between allostatic load and the 20 decline scores was 0.43 (P = .03) and the [25th, 75th] percentile interval of its distribution over 200 bootstrapped subsamples of the cohort was [0.48, 0.53], These findings were not substantially affected by adjusting for covariates and cardiovascular disease. We conclude that a summary measure of physiologic dysregulation. such as allostatic load, is an independent predictor of functional decline in elderly men and women. (C) 2002 Elsevier Science Inc. All rights reserved.
C1 Univ Calif Los Angeles, Sch Med, Dept Med, Div Geriatr, Los Angeles, CA USA.
   Princeton Univ, Off Populat Res, Princeton, NJ USA.
   Rockefeller Univ, Neuroendocrinol Lab, New York, NY 10021 USA.
   Aetna Inc, Hartford, CT USA.
C3 University of California System; University of California Los Angeles;
   University of California Los Angeles Medical Center; David Geffen School
   of Medicine at UCLA; Princeton University; Rockefeller University
RP Univ Calif Los Angeles, Sch Med, Dept Med, Div Geriatr, Los Angeles, CA USA.
EM akarlamangla@medntt.ucla.edu
RI McEwen, Bruce/Z-1630-2019
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NR 75
TC 354
Z9 446
U1 1
U2 43
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0895-4356
EI 1878-5921
J9 J CLIN EPIDEMIOL
JI J. Clin. Epidemiol.
PD JUL
PY 2002
VL 55
IS 7
BP 696
EP 710
AR PII S0895-4356(02)00399-2
DI 10.1016/S0895-4356(02)00399-2
PG 15
WC Health Care Sciences & Services; Public, Environmental & Occupational
   Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services; Public, Environmental & Occupational
   Health
GA 576HA
UT WOS:000176996600010
PM 12160918
DA 2025-06-11
ER

PT J
AU Mesarwi, OA
   Loomba, R
   Malhotra, A
AF Mesarwi, Omar A.
   Loomba, Rohit
   Malhotra, Atul
TI Obstructive Sleep Apnea, Hypoxia, and Nonalcoholic Fatty Liver Disease
SO AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
LA English
DT Review
DE metabolic syndrome; sleep disordered breathing; insulin resistance;
   dyslipidemia; intermittent hypoxia
ID CHRONIC INTERMITTENT HYPOXIA; POSITIVE AIRWAY PRESSURE;
   INSULIN-RESISTANCE; SUSTAINED HYPOXIA; OXIDATIVE STRESS; BLOOD-PRESSURE;
   OBESE-PATIENTS; BODY-WEIGHT; MOUSE MODEL; SYMPATHETIC ACTIVITY
AB Recent studies have demonstrated that obstructive sleep apnea (OSA) is associated with the development and evolution of nonalcoholic fatty liver disease (NAFLD), independent of obesity or other shared risk factors. Like OSA, NAFLD is a prevalent disorder associated with major adverse health outcomes: Patients with NAFLD may develop cirrhosis, liver failure, and hepatocellular carcinoma. One major finding that has emerged from these studies is that the OSA-NAFLD association is related to the degree of nocturnal hypoxemia in OSA. Animal models have therefore largely focused on intermittent hypoxia, a key manifestation of OSA, to shed light on the mechanisms by which OSA may give rise to the complex metabolic disturbances that are seen in NAFLD. Intermittent hypoxia leads to tissue hypoxia and can result in oxidative stress, mitochondrial dysfunction, inflammation, and overactivation of the sympathetic nervous system, among many other maladaptive effects. In such models, intermittent hypoxia has been shown to cause insulin resistance, dysfunction of key steps in hepatic lipid metabolism, atherosclerosis, and hepatic steatosis and fibrosis, each of which is pertinent to the development and/or progression of NAFLD. However, many intriguing questions remain unanswered: Principally, how aggressively should the clinician screen for NAFLD in patients with OSA, and vice versa? In this review, we attempt to apply the best evidence from animal and human studies to highlight the relationship between these two disorders and to advocate for further trials aimed at defining these relationships more precisely.
C1 [Mesarwi, Omar A.; Malhotra, Atul] Univ Calif San Diego, Sch Med, Div Pulm Crit Care & Sleep Med, La Jolla, CA 92093 USA.
   [Loomba, Rohit] Univ Calif San Diego, Sch Med, Div Gastroenterol, Dept Med, La Jolla, CA 92093 USA.
   [Loomba, Rohit] Univ Calif San Diego, Sch Med, Dept Family Med & Publ Hlth, La Jolla, CA 92093 USA.
C3 University of California System; University of California San Diego;
   University of California System; University of California San Diego;
   University of California System; University of California San Diego
RP Mesarwi, OA (corresponding author), UC San Diego Sch Med, Div Pulm Crit Care & Sleep Med, Dept Med, 9300 Campus Point Dr,Mail Code 7381, La Jolla, CA 92037 USA.
EM omesarwi@ucsd.edu
RI Loomba, Rohit/AAE-7831-2019
OI Loomba, Rohit/0000-0002-4845-9991
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NR 113
TC 171
Z9 187
U1 1
U2 21
PU AMER THORACIC SOC
PI NEW YORK
PA 25 BROADWAY, 18 FL, NEW YORK, NY 10004 USA
SN 1073-449X
EI 1535-4970
J9 AM J RESP CRIT CARE
JI Am. J. Respir. Crit. Care Med.
PD APR 1
PY 2019
VL 199
IS 7
BP 830
EP 841
DI 10.1164/rccm.201806-1109TR
PG 12
WC Critical Care Medicine; Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Respiratory System
GA HR2XX
UT WOS:000463002100011
PM 30422676
OA Green Published
DA 2025-06-11
ER

PT J
AU Valcarcel-Ares, MN
   Tucsek, Z
   Kiss, T
   Giles, CB
   Tarantini, S
   Yabluchanskiy, A
   Balasubramanian, P
   Gautam, T
   Galvan, V
   Ballabh, P
   Richardson, A
   Freeman, WM
   Wren, JD
   Deak, F
   Ungvari, Z
   Csiszar, A
AF Valcarcel-Ares, Marta Noa
   Tucsek, Zsuzsanna
   Kiss, Tamas
   Giles, Cory B.
   Tarantini, Stefano
   Yabluchanskiy, Andriy
   Balasubramanian, Priya
   Gautam, Tripti
   Galvan, Veronica
   Ballabh, Praveen
   Richardson, Arlan
   Freeman, Willard M.
   Wren, Jonathan D.
   Deak, Ferenc
   Ungvari, Zoltan
   Csiszar, Anna
TI Obesity in Aging Exacerbates Neuroinflammation, Dysregulating Synaptic
   Function-Related Genes and Altering Eicosanoid Synthesis in the Mouse
   Hippocampus: Potential Role in Impaired Synaptic Plasticity and
   Cognitive Decline
SO JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL
   SCIENCES
LA English
DT Article
DE Metabolic syndrome; Vascular cognitive impairment; VCI; Mild cognitive
   impairment; Inflammaging
ID LONG-TERM POTENTIATION; HIGH-FAT DIET; BETA-AMYLOID GENERATION;
   OXIDATIVE STRESS; MEMORY; EXPRESSION; HYPERTENSION; INFLAMMATION;
   PERFORMANCE; MICROGLIA
AB There is strong evidence that obesity has deleterious effects on cognitive function of older adults. Previous preclinical studies demonstrate that obesity in aging is associated with a heightened state of systemic inflammation, which exacerbates bloodbrain barrier disruption, promoting neuroinflammation and oxidative stress. To test the hypothesis that synergistic effects of obesity and aging on inflammatory processes exert deleterious effects on hippocampal function, young and aged C57BL/6 mice were rendered obese by chronic feeding of a high-fat diet followed by assessment of learning and memory function, measurement of hippocampal long-term potentiation (LTP), assessment of changes in hippocampal expression of genes relevant for synaptic function and determination of synaptic density. Because there is increasing evidence that altered production of lipid mediators modulate LTP, neuroinflammation and neurovascular coupling responses, the effects of obesity on hippocampal levels of relevant eicosanoid mediators were also assessed. We found that aging exacerbates obesity-induced microglia activation, which is associated with deficits in hippocampal-dependent learning and memory tests, impaired LTP, decreased synaptic density, and dysregulation of genes involved in regulation of synaptic plasticity. Obesity in aging also resulted in an altered hippocampal eicosanoid profile, including decreases in vasodilator and pro-LTP epoxy-eicosatrienoic acids (EETs). Collectively, our results taken together with previous findings suggest that obesity in aging promotes hippocampal inflammation, which in turn may contribute to synaptic dysfunction and cognitive impairment.
C1 [Valcarcel-Ares, Marta Noa; Tucsek, Zsuzsanna; Kiss, Tamas; Giles, Cory B.; Tarantini, Stefano; Yabluchanskiy, Andriy; Balasubramanian, Priya; Gautam, Tripti; Richardson, Arlan; Freeman, Willard M.; Wren, Jonathan D.; Deak, Ferenc; Ungvari, Zoltan; Csiszar, Anna] Univ Oklahoma, Hlth Sci Ctr, Dept Geriatr Med, Reynolds Oklahoma Ctr Aging, Oklahoma City, OK USA.
   [Giles, Cory B.; Wren, Jonathan D.] Oklahoma Med Res Fdn, Arthrit & Clin Immunol Res Program, 825 NE 13th St, Oklahoma City, OK 73104 USA.
   [Galvan, Veronica] Univ Texas Hlth Sci Ctr San Antonio, Barshop Inst Longev & Aging Studies, San Antonio, TX 78229 USA.
   [Galvan, Veronica] Univ Texas Hlth Sci Ctr San Antonio, Dept Physiol, San Antonio, TX 78229 USA.
   [Ballabh, Praveen] Albert Einstein Coll Med, Dept Pediat, Div Neonatol, Bronx, NY 10467 USA.
   [Richardson, Arlan] Oklahoma City VA Med Ctr, Oklahoma City, OK USA.
   [Deak, Ferenc] Univ Oklahoma, Hlth Sci Ctr, Oklahoma Ctr Neurosci, Oklahoma City, OK USA.
   [Csiszar, Anna] Semmelweis Univ, Dept Pulmonol, Budapest, Hungary.
   [Ungvari, Zoltan] Univ Szeged, Dept Med Phys & Informat, Szeged, Hungary.
C3 University of Oklahoma System; University of Oklahoma Health Sciences
   Center; Oklahoma Medical Research Foundation; University of Texas
   System; University of Texas Health Science Center at San Antonio;
   University of Texas System; University of Texas Health Science Center at
   San Antonio; Montefiore Medical Center; Albert Einstein College of
   Medicine; Yeshiva University; University of Oklahoma System; University
   of Oklahoma Health Sciences Center; University of Oklahoma System;
   University of Oklahoma Health Sciences Center; Semmelweis University;
   Szeged University
RP Csiszar, A (corresponding author), Univ Oklahoma HSC, Dept Geriatr Med, Reynolds Oklahoma Ctr Aging, 975 NE 10th St,BRC 1303, Oklahoma City, OK 73104 USA.
EM anna-csiszar@ouhsc.edu
RI Wren, Jonathan/E-5611-2011; Freeman, Willard/GYQ-5841-2022; Deak,
   Ferenc/AAE-4324-2019; Tarantini, Stefano/JMQ-7733-2023; Ungvari,
   Zoltan/GZK-8127-2022
OI Yabluchanskiy, Andriy/0000-0002-9648-7161; Kiss,
   Tamas/0000-0001-5339-5227
FU American Heart Association; National Institute on Aging [R01-AG055395,
   R01-AG047879, R01-AG038747]; National Institute of Neurological
   Disorders and Stroke (NINDS) [R01-NS056218, R01-NS100782]; NIH
   [U54GM104938]; Oklahoma Center for the Advancement of Science and
   Technology; Presbyterian Health Foundation; Oklahoma Nathan Shock Aging
   Center [P30-AG050911]; NIA [T32AG052363]; EU [EFOP-3.6.1-16-2016-00008]
FX This work was supported by grants from the American Heart Association
   (to S.T., M.N.V.A.), the National Institute on Aging (R01-AG055395,
   R01-AG047879; R01-AG038747), the National Institute of Neurological
   Disorders and Stroke (NINDS; R01-NS056218, R01-NS100782), NIH-supported
   Oklahoma Shared Clinical and Translational Resources (U54GM104938), the
   Oklahoma Center for the Advancement of Science and Technology (to A.C.,
   Z.U., F.D., A.Y.) and the Presbyterian Health Foundation (to F.D., A.C.,
   U.Z.) and the Oklahoma Nathan Shock Aging Center (P30-AG050911). The
   authors acknowledge the support from the NIA-funded Geroscience Training
   Program in Oklahoma (T32AG052363) and the EU-funded
   EFOP-3.6.1-16-2016-00008 (to Z.U.). These authors contributed equally to
   this work.
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NR 49
TC 81
Z9 93
U1 0
U2 28
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1079-5006
EI 1758-535X
J9 J GERONTOL A-BIOL
JI J. Gerontol. Ser. A-Biol. Sci. Med. Sci.
PD MAR
PY 2019
VL 74
IS 3
BP 290
EP 298
DI 10.1093/gerona/gly127
PG 9
WC Geriatrics & Gerontology; Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA HQ1XJ
UT WOS:000462192600003
PM 29893815
OA Green Published
DA 2025-06-11
ER

PT J
AU Norris, KM
   Okie, W
   Yakaitis, CL
   Pazdro, R
AF Norris, Katie M.
   Okie, Whitney
   Yakaitis, Claire L.
   Pazdro, Robert
TI The anthocyanin cyanidin-3-O-β-glucoside modulates murine
   glutathione homeostasis in a manner dependent on genetic background
SO REDOX BIOLOGY
LA English
DT Article
DE Oxidative stress; Anthocyanin; Cyandin-3-O-beta-glucoside; Polyphenol;
   Antioxidant; Glutathione
ID DIETARY FLAVONOID INTAKE; CARDIOVASCULAR-DISEASE MORTALITY; CRANBERRY
   JUICE CONSUMPTION; POSTMENOPAUSAL WOMEN; ANTIOXIDANT STATUS; METABOLIC
   SYNDROME; OXIDATIVE STRESS; REDOX STATUS; HEART-DISEASE; US ADULTS
AB Anthocyanins are a class of phytochemicals that have generated considerable interest due to their reported health benefits. It has been proposed that commonly consumed anthocyanins, such as cyandin-3-O-beta-glucoside (C3G), confer cellular protection by stimulating biosynthesis of glutathione (GSH), an endogenous antioxidant. Currently, it is unknown whether the health effects of dietary anthocyanins are genetically determined. We therefore tested the hypothesis that anthocyanin-induced alterations in GSH homeostasis vary by genetic background. Mice representing five genetically diverse inbred strains (A/J, 129S1/SvImJ, CAST/EiJ, C57BL/6J, and NOD/ShiLtJ) were assigned to a control or 100 mg/kg C3G diet (n=5/diet/strain) for six weeks. GSH and GSSG levels were quantified in liver, kidney, heart, pancreas, and brain samples using HPLC. The C3G diet promoted an increase in renal GSH concentrations, hepatic GSH/GSSG, and cardiac GSH/GSSG in CAST/EiJ mice. C3G treatment also induced an increase in pancreatic GSH/GSSG in C57BL/6J mice. In contrast, C3G did not affect GSH homeostasis in NOD/ShiLtJ mice. Surprisingly, the C3G-diet caused a decrease in hepatic GSH/GSSG in A/J and 129S1/SvImJ mice compared to controls; C3G-treated 129S1/SvImJ mice also exhibited lower total glutathione in the heart. Overall, we discovered that C3G modulates the GSH system in a strain- and tissue-specific manner. To our knowledge, this study is the first to show that the redox effects of anthocyanins are determined by genetic background. (C) 2016 The Authors. Published by Elsevier B.V.
C1 [Norris, Katie M.; Okie, Whitney; Yakaitis, Claire L.; Pazdro, Robert] Univ Georgia, Dept Food & Nutr, 305 Sanford Dr, Athens, GA 30602 USA.
C3 University System of Georgia; University of Georgia
RP Pazdro, R (corresponding author), Univ Georgia, Dept Food & Nutr, 305 Sanford Dr, Athens, GA 30602 USA.
EM kmn@uga.edu; whitokie@uga.edu; claireyak@uga.edu; rpazdro@uga.edu
FU University of Georgia Office of the Vice President for Research; College
   of Family and Consumer Sciences; NIFA HATCH Grant [GEO00735]
FX This work was supported by the University of Georgia Office of the Vice
   President for Research; the College of Family and Consumer Sciences; and
   NIFA HATCH Grant GEO00735.
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NR 55
TC 14
Z9 15
U1 0
U2 14
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 2213-2317
J9 REDOX BIOL
JI Redox Biol.
PD OCT
PY 2016
VL 9
BP 254
EP 263
DI 10.1016/j.redox.2016.08.014
PG 10
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA EA6RQ
UT WOS:000386757000027
PM 27591835
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Ramirez-Sanchez, I
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   Nogueira, L
   Coe, T
   Perkins, G
   Hogan, M
   Maisel, AS
   Henry, RR
   Ceballos, G
   Villarreal, F
AF Ramirez-Sanchez, Israel
   Taub, Pam R.
   Ciaraldi, Theodore P.
   Nogueira, Leonardo
   Coe, Taylor
   Perkins, Guy
   Hogan, Michael
   Maisel, Alan S.
   Henry, Robert R.
   Ceballos, Guillermo
   Villarreal, Francisco
TI (-)-Epicatechin rich cocoa mediated modulation of oxidative stress
   regulators in skeletal muscle of heart failure and type 2 diabetes
   patients
SO INTERNATIONAL JOURNAL OF CARDIOLOGY
LA English
DT Article
DE Epicatechin; Cocoa; Flavanols
ID METABOLIC SYNDROME; ENZYME-ACTIVITY; BLOOD-PRESSURE; CONSUMPTION;
   CAPACITY; EXERCISE; HUMANS; MODEL
AB Background: Type 2 diabetes (T2D) and heart failure (HF) are associated with high levels of skeletal muscle (SkM) oxidative stress (OS). Health benefits attributed to flavonoids have been ascribed to antioxidation. However, for flavonoids with similar antioxidant potential, end-biological effects vary widely suggesting other mechanistic venues for reducing OS. Decreases in OS may followthe modulation of key regulatory pathways including antioxidant levels (e.g. glutathione) and enzymes such as mitochondrial superoxide dismutase (SOD2) and catalase.
   Methods: We examined OS-related alterations in SkMin T2D/HF patients (as compared vs. healthy controls) and evaluated the effects of three-month treatment with (-)-epicatechin (Epi) rich cocoa (ERC). To evidence Epi as the mediator of the improved OS profile we examined the effects of pure Epi (vs. water) on SkM OS regulatory systems in a mouse model of insulin resistance and contrasted results vs. normal mice.
   Results: There were severe alterations in OS regulatory systems in T2D/HF SkM as compared with healthy controls. Treatment with ERC induced recovery in glutathione levels and decreases in the nitrotyrosilation and carbonylation of proteins. With treatment, key transcriptional factors translocate into the nucleus leading to increases in SOD2 and catalase protein expression and activity levels. In insulin resistant mice, there were alterations in muscle OS and pure Epi replicated the beneficial effects of ERC found in humans.
   Conclusions: Major perturbations in SkM OS can be reversed with ERC in T2D/HF patients. Epi likely mediates such effects and may provide an effective means to treat conditions associated with tissue OS. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
C1 [Taub, Pam R.; Ciaraldi, Theodore P.; Nogueira, Leonardo; Coe, Taylor; Perkins, Guy; Hogan, Michael; Maisel, Alan S.; Henry, Robert R.; Villarreal, Francisco] Univ Calif San Diego, Sch Med, La Jolla, CA 92093 USA.
   [Ciaraldi, Theodore P.; Maisel, Alan S.; Henry, Robert R.] VA San Diego Healthcare Syst, San Diego, CA USA.
   [Ramirez-Sanchez, Israel; Ceballos, Guillermo] Inst Politecn Nacl, Escuela Super Med, Secc Posgrad, Mexico City, DF, Mexico.
C3 University of California System; University of California San Diego; US
   Department of Veterans Affairs; Veterans Health Administration (VHA); VA
   San Diego Healthcare System; Instituto Politecnico Nacional - Mexico
RP Villarreal, F (corresponding author), UCSD Sch Med, 9500 Gilman Dr 0613J, La Jolla, CA 92093 USA.
EM fvillarr@ucsd.edu
RI Nogueira, Leonardo/H-5662-2013; Ceballos, Guillermo/A-7507-2013
OI Taub, Pam/0000-0002-0684-0655; Ceballos, Guillermo/0000-0003-2155-3934;
   Perkins, Guy/0000-0002-1834-6646; Nogueira, Leonardo/0000-0001-5194-9126
FU NIH [AT4277, HL43617, P60-MD000220, DK92154]; Medical Research Service,
   Department of Veterans Affairs; VA San Diego Healthcare System and an
   unrestricted gift from Cardero Therapeutics Inc.
FX This study was supported by NIH AT4277, HL43617, P60-MD000220, and
   DK92154 and grants from the Medical Research Service, Department of
   Veterans Affairs, VA San Diego Healthcare System and an unrestricted
   gift from Cardero Therapeutics Inc.
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NR 36
TC 78
Z9 81
U1 1
U2 34
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0167-5273
EI 1874-1754
J9 INT J CARDIOL
JI Int. J. Cardiol.
PD OCT 9
PY 2013
VL 168
IS 4
BP 3982
EP 3990
DI 10.1016/j.ijcard.2013.06.089
PG 9
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 242EG
UT WOS:000326219600136
PM 23870648
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Bogdanski, P
   Szulinska, M
   Suliburska, J
   Pupek-Musialik, D
   Jablecka, A
   Witmanowski, H
AF Bogdanski, P.
   Szulinska, M.
   Suliburska, J.
   Pupek-Musialik, D.
   Jablecka, A.
   Witmanowski, H.
TI Supplementation with L-arginine favorably influences plasminogen
   activator inhibitor type 1 concentration in obese patients. A
   randomized, double blind trial
SO JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
LA English
DT Article
DE Insulin sensitivity; L-arginine; Obesity; oxidative stress; PAI 1
ID NECROSIS-FACTOR-ALPHA; INSULIN-RESISTANCE; OXIDATIVE STRESS;
   MYOCARDIAL-INFARCTION; GENE POLYMORPHISMS; METABOLIC SYNDROME;
   CONVERTING-ENZYME; SKELETAL-MUSCLE; ELEVATED LEVELS; NITRIC-OXIDE
AB Background: Elevated plasminogen activator inhibitor type 1 (PAI 1) plays an important role in the pathogenesis of excess blood coagulability in obese patients. L-arginine supplementation has shown to be associated with enhanced cardiovascular and metabolic health. The aim of the study was to assess the effect of L-arginine supplementation on PAI 1 concentration and to evaluate the relation to changes in nitric oxide (NO) plasma level, insulin sensitivity (M value), and total antioxidant status (TAS) in obese patients. Material/subjects and methods: A randomized, double-blind, placebo-controlled study was conducted from March 2010 to June 2011. Eighty-eight obese patients were randomly assigned to receive either 9 g of L-arginine or placebo daily for 6 months. At baseline and after 6 months, selected anthropometrical measurements and blood biochemical analyses were performed, and PAI 1, NO, TAS levels were assessed. Insulin sensitivity was evaluated using the hyperinsulinemic euglycemic clamp technique. Results: We found that 6-month L-arginine supplementation resulted in significant decrease of PAI 1. Significant increase of NO, TAS, and insulin sensitivity level were noticed. In a group of patients treated with L-arginine, negative correlation between a change of insulin sensitivity value and a change of PAI 1 concentration was found. Conclusions: The present findings demonstrate favorable influence of L-arginine supplementation on PAI 1 concentration in obese patients. Beneficial influence is related to insulin sensitivity improvement. The potential therapeutic role of L-arginine administration in patients with obesity needs further investigation. (C) 2013, Editrice Kurtis
C1 [Bogdanski, P.; Szulinska, M.; Pupek-Musialik, D.] Poznan Univ Med Sci, Dept Internal Med Metab Disorders & Hypertens, PL-60569 Poznan, Poland.
   [Suliburska, J.] Poznan Univ Med Sci, Dept Human Nutr & Hyg, PL-60569 Poznan, Poland.
   [Jablecka, A.] Poznan Univ Med Sci, Dept Clin Pharmacol, PL-60569 Poznan, Poland.
   [Witmanowski, H.] Poznan Univ Med Sci, Dept Physiol, PL-60569 Poznan, Poland.
   [Witmanowski, H.] Nicolaus Copernicus Univ, Dept Plast Surg, Ludwik Rydygier Coll Med Bydgoszcz, Bydgoszcz, Poland.
C3 Poznan University of Medical Sciences; Poznan University of Medical
   Sciences; Poznan University of Medical Sciences; Poznan University of
   Medical Sciences; Nicolaus Copernicus University
RP Bogdanski, P (corresponding author), Poznan Univ Med Sci, Dept Internal Med Metab Disorders & Hypertens, Szamaizewskiego 84 Str, PL-60569 Poznan, Poland.
EM pawelbogdanski@wp.pl
RI Bogdański, Paweł/ABB-2938-2020; Szulińska, Monika/ABB-7157-2021
OI Jablecka, Anna/0000-0001-7132-8159; szulinska,
   monika/0000-0002-1163-0919; Suliburska, Joanna/0000-0002-0937-8427;
   Bogdanski, Pawel/0000-0002-0563-1624
FU Ministry of Science and Higher Education, Poland [501-01-01119172-07897,
   501-01-01125184-09055]
FX The article has been reviewed and edited by an established
   English-language editing service. The research was supported in part by
   grants from the Ministry of Science and Higher Education, Poland (No.
   501-01-01119172-07897 and 501-01-01125184-09055).
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NR 40
TC 25
Z9 25
U1 0
U2 5
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1720-8386
J9 J ENDOCRINOL INVEST
JI J. Endocrinol. Invest.
PD APR
PY 2013
VL 36
IS 4
BP 221
EP 226
DI 10.3275/8467
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 163QQ
UT WOS:000320352400003
PM 22732180
DA 2025-06-11
ER

PT J
AU Anderson, SE
   Whitaker, RC
AF Anderson, Sarah E.
   Whitaker, Robert C.
TI Attachment Security and Obesity in US Preschool-Aged Children
SO ARCHIVES OF PEDIATRICS & ADOLESCENT MEDICINE
LA English
DT Article
ID BODY-MASS INDEX; CHRONIC STRESS; METABOLIC SYNDROME; RIGHT BRAIN;
   Q-SORT; CHILDHOOD; INTERVENTIONS; OVERWEIGHT; CLASSIFICATIONS;
   RECOMMENDATIONS
AB Objective: To estimate the association between attachment security in children aged 24 months and their risk for obesity at 4 1/2 years of age. Insecure attachment is associated with unhealthy physiologic and behavioral responses to stress, which could lead to development of obesity.
   Design: Cohort study.
   Setting: National sample of US children born in 2001.
   Participants: Children and mothers participating in the 2003 and 2005-2006 waves of the Early Childhood Longitudinal Study, Birth Cohort, conducted by the National Center for Education Statistics. Our analytic sample included 6650 children (76.0% of children assessed in both waves).
   Main Exposure: Attachment security at 24 months was assessed by trained interviewers during observation in the child's home. Insecure attachment was defined as lowest quartile of attachment security, based on the security score from the Toddler Attachment Sort-45 Item.
   Outcome Measure: Obesity at 4 1/2 years of age (sex-specific body mass index >= 95th percentile for age).
   Results: The prevalence of obesity was 23.1% in children with insecure attachment and 16.6% in those with secure attachment. For children with insecure attachment, the odds of obesity were 1.30 (95% confidence interval, 1.05-1.62) times higher than for children with secure attachment after controlling for the quality of mother-child interaction during play, parenting practices related to obesity, maternal body mass index, and sociodemographic characteristics.
   Conclusions: Insecure attachment in early childhood may be a risk factor for obesity. Interventions to increase children's attachment security should examine the effects on children's weight.
C1 [Anderson, Sarah E.] Ohio State Univ, Div Epidemiol, Coll Publ Hlth, Columbus, OH 43210 USA.
   [Whitaker, Robert C.] Temple Univ, Dept Publ Hlth, Ctr Obes Res & Educ, Philadelphia, PA 19122 USA.
   [Whitaker, Robert C.] Temple Univ, Dept Pediat, Ctr Obes Res & Educ, Philadelphia, PA 19122 USA.
C3 University System of Ohio; Ohio State University; Pennsylvania
   Commonwealth System of Higher Education (PCSHE); Temple University;
   Pennsylvania Commonwealth System of Higher Education (PCSHE); Temple
   University
RP Anderson, SE (corresponding author), Ohio State Univ, Div Epidemiol, Coll Publ Hlth, 320 W 10th Ave,Starling Loving Hall,Room B216, Columbus, OH 43210 USA.
EM sanderson@cph.osu.edu
RI Anderson, Sarah/A-9792-2008
FU National Institutes of Health [1R01DK088913]
FX This work was supported in part by grant 1R01DK088913 from the National
   Institutes of Health.Role of the Sponsor: All data used in this study
   were collected by the National Center for Education Statistics, within
   the Institute of Education Sciences of the US Department of Education. A
   license agreement is in place with The Ohio State University for
   analysis of restricted-use data from this study. The manuscript was
   cleared by the National Center for Education Statistics Data Security
   Office after disclosure review. Neither the sponsor nor the funder was
   involved in the design or conduct of the analyses, interpretation of
   results, preparation or approval of the manuscript, or decision to
   publish the study.
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NR 62
TC 90
Z9 112
U1 0
U2 49
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 1072-4710
EI 1538-3628
J9 ARCH PEDIAT ADOL MED
JI Arch. Pediatr. Adolesc. Med.
PD MAR
PY 2011
VL 165
IS 3
BP 235
EP 242
DI 10.1001/archpediatrics.2010.292
PG 8
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Pediatrics
GA 731EA
UT WOS:000288087900009
PM 21383273
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Nocito, A
   Dahm, F
   Jochum, W
   Jang, JH
   Georgiev, P
   Bader, M
   Renner, EL
   Clavien, PA
AF Nocito, Antonio
   Dahm, Felix
   Jochum, Wolfram
   Jang, Jae Hwi
   Georgiev, Panco
   Bader, Michael
   Renner, Eberhard Ludwig
   Clavien, Pierre-Alain
TI Serotonin mediates oxidative stress and mitochondrial toxicity in a
   murine model of nonalcoholic steatohepatitis
SO GASTROENTEROLOGY
LA English
DT Article
ID FATTY LIVER-DISEASE; FIBROSIS; PREDICTORS; EXPRESSION; SYSTEM; CYP2E1
AB Background & Aims: Nonalcoholic steatohepatitis (NASH) is one of the most common causes of liver enzyme elevation in the West. Its prevalence is likely to increase further, paralleling the epidemic increase of the metabolic syndrome. Serotonin degradation by monoamine oxidase A (MAO-A) was recently implicated as an important source of reactive oxygen species. We therefore tested the pathogenetic role of serotonin in a murine model of diet-induced steatohepatitis. Methods: Wild-type and serotonin-deficient mice, tryptophan hydroxylase 1 (Tph1(-/-)) were fed a choline-methionine-deficient diet for 2 and 6 weeks. MAO-A was inhibited with clorgyline. Steatosis, hepatocyte injury, and hepatic inflammation were assessed by histology, immunohistochemistry, and biochemical analysis. Expression levels of MAO-A and serotonin transporter were analyzed by reverse-transcription polymerase chain reaction and Western blot. Oxidative stress was detected by measuring lipid peroxidation. Mitochondrial damage was determined by electron microscopy and quantification of cytochrome c release. Results: After choline-methionine-deficient diet, Tph1(-/-) mice displayed an equal degree of steatosis, yet reduced hepatocellular injury and less severe inflammation. The difference in these NASH-defining features could be attributed to, an increased uptake and catabolism of serotonin, yielding enhanced levels of reactive oxygen species and lipid peroxides, which mediated hepatocellular injury by mitochondrial damage and inflammation. Inhibition of MAO-A reduced hepatocellular damage in wild-type mice. Correspondingly, MAO-A expression was up-regulated significantly in human NASH. Conclusions: This study provides evidence that serotonin plays a role in the pathogenesis of steatohepatitis, and therefore might represent a novel target for the prevention and treatment of NASH.
C1 Univ Zurich Hosp, Dept Visceral & Transplantat Surg, Swiss Hepatopancreatobiliary Ctr, CH-8091 Zurich, Switzerland.
   Univ Zurich Hosp, Dept Pathol, CH-8091 Zurich, Switzerland.
   Max Delbruck Ctr Mol Med, Berlin, Germany.
   Univ Manitoba, Dept Internal Med, Sect Hepatol, Winnipeg, MB R3E 0V9, Canada.
C3 University of Zurich; University Zurich Hospital; University of Zurich;
   University Zurich Hospital; Helmholtz Association; Max Delbruck Center
   for Molecular Medicine; University of Manitoba
RP Clavien, PA (corresponding author), Univ Zurich Hosp, Dept Visceral & Transplantat Surg, Swiss Hepatopancreatobiliary Ctr, Ramistr 100, CH-8091 Zurich, Switzerland.
EM clavien@chir.unizh.ch
RI Bader, Michael/K-2124-2013; Dahm, Felix/B-2672-2008
OI Dahm, Felix/0000-0001-5589-8960; Bader, Michael/0000-0003-4780-4164
FU NIDDK NIH HHS [DK54048-04] Funding Source: Medline
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U2 26
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0016-5085
EI 1528-0012
J9 GASTROENTEROLOGY
JI Gastroenterology
PD AUG
PY 2007
VL 133
IS 2
BP 608
EP 618
DI 10.1053/j.gastro.2007.05.019
PG 11
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 197VW
UT WOS:000248585600030
PM 17681180
DA 2025-06-11
ER

PT J
AU Song, ZC
   Bu, S
   Sang, SZ
   Li, J
   Zhang, XH
   Song, X
   Ran, YQ
AF Song, Zhicong
   Bu, Shuai
   Sang, Suzhen
   Li, Jie
   Zhang, Xihai
   Song, Xu
   Ran, Yuqin
TI The Active Components of Traditional Chinese Medicines Regulate the
   Multi-Target Signaling Pathways of Metabolic Dysfunction-Associated
   Fatty Liver Disease
SO DRUG DESIGN DEVELOPMENT AND THERAPY
LA English
DT Review
DE metabolic dysfunction-associated fatty liver disease; traditional
   Chinese medicine; active ingredient; lipid metabolism disorder; action
   mechanism
ID AMELIORATES HEPATIC STEATOSIS; LIPID-METABOLISM; NONALCOHOLIC
   STEATOHEPATITIS; RAT MODEL; DIET; ACID; POLYSACCHARIDE; ACTIVATION;
   FIBROSIS; ACCUMULATION
AB Metabolic dysfunction-associated fatty liver disease (MAFLD), which is characterized by hepatocyte lipid accumulation driven by systemic metabolic dysregulation, represents a critical therapeutic challenge in the context of the global metabolic syndrome epidemic. The clinically recommended drugs for MAFLD mainly include antioxidants, hepatoprotective anti-inflammatory drugs, and weight-loss drugs. However, the mechanisms underlying the progression of MAFLD is characterized by nonlinearity, highlighting the urgent need for safer multi-target alternative therapies. Although existing single-target pharmacological interventions often show limited efficacy and adverse effects, the multi-component and multi-target nature of the active ingredients in traditional Chinese medicine (TCM) formulations represent new opportunities for systemic metabolic regulation. In this study, by searching PubMed and Web of Science, we identified 108 experimental studies. By evaluating multiple mechanisms, such as improving lipid metabolism and insulin resistance, alleviating oxidative stress damage, inhibiting liver inflammation, suppressing liver fibrosis, reducing endoplasmic reticulum stress, regulating hepatocyte autophagy, inhibiting hepatocyte apoptosis, improving mitochondrial dysfunction, and regulating the intestinal flora, we constructed a cross-scale regulatory network for the treatment of MAFLD by the active components of TCM. Subsequently, the dynamic target groups were screened, and a new paradigm of "mechanism-oriented and spatiotemporaloptimized" design for TCM compound prescriptions was proposed, providing a theoretical framework for the development of precise therapies that can improve liver lipid metabolism, block inflammation and fibrosis, and restore intestinal homeostasis.
C1 [Song, Zhicong; Zhang, Xihai; Ran, Yuqin] Shandong Univ Tradit Chinese Med, Sch Clin Med 1, Jinan, Shandong, Peoples R China.
   [Bu, Shuai; Song, Xu] Shandong Univ Tradit Chinese Med, Affiliated Hosp 2, Dept Cardiol, 1 Jingba Rd, Jinan 250001, Shandong, Peoples R China.
   [Sang, Suzhen] Shandong Acad Tradit Chinese Med, Affiliated Hosp, Jinan, Shandong, Peoples R China.
   [Li, Jie] Shandong Univ Tradit Chinese Med, Sci Res Off, Jinan, Shandong, Peoples R China.
C3 Shandong University of Traditional Chinese Medicine; Shandong University
   of Traditional Chinese Medicine; Shandong University of Traditional
   Chinese Medicine
RP Bu, S (corresponding author), Shandong Univ Tradit Chinese Med, Affiliated Hosp 2, Dept Cardiol, 1 Jingba Rd, Jinan 250001, Shandong, Peoples R China.
EM bushuai1237@126.com
FU National Key Research and Development Plan Project [2023YFC3606203];
   Shandong Taishan Scholars Project Special Fund Project [ts201712097];
   Shandong Medicine and Health Science and Technology Youth Project
   [202303031041]
FX This work was supported by National Key Research and Development Plan
   Project (Fund No.: 2023YFC3606203), Shandong Taishan Scholars Project
   Special Fund Project (Fund No.: ts201712097), and Shandong Medicine and
   Health Science and Technology Youth Project (Fund No.: 202303031041).
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NR 125
TC 0
Z9 0
U1 3
U2 3
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1177-8881
J9 DRUG DES DEV THER
JI Drug Des. Dev. Ther.
PY 2025
VL 19
BP 2693
EP 2715
DI 10.2147/DDDT.S514498
PG 23
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 1GF2D
UT WOS:001464276300001
PM 40231197
DA 2025-06-11
ER

PT J
AU Di Porzio, A
   Barrella, V
   Gatto, C
   Cigliano, L
   Spagnuolo, MS
   Crescenzo, R
   Romano, I
   Mauriello, G
   Iossa, S
   Mazzoli, A
AF Di Porzio, Angela
   Barrella, Valentina
   Gatto, Cristina
   Cigliano, Luisa
   Spagnuolo, Maria Stefania
   Crescenzo, Raffaella
   Romano, Ida
   Mauriello, Gianluigi
   Iossa, Susanna
   Mazzoli, Arianna
TI Protective effect of probiotic Limosilactobacillus reuteri
   DSM17938 against western diet-induced obesity and associated metabolic
   alterations
SO JOURNAL OF FUNCTIONAL FOODS
LA English
DT Article
DE Western diet; Probiotic; Insulin resistance; Energy balance;
   Mitochondria; Oxidative stress
ID FATTY LIVER-DISEASE; INSULIN-RESISTANCE; DSM 17938; HEPATIC STEATOSIS;
   GUT MICROBIOTA; MITOCHONDRIA; SUPPLEMENTATION; EPIDEMIOLOGY;
   PATHOGENESIS; PREBIOTICS
AB Purpose: To evaluate the possible application of Limosilactobacillus reuteri DSM 17938 as a strategy to prevent Western Diet-induced metabolic alterations and liver dysfunction.Methods: Male Wistar rats of 90 days were divided in three groups and fed a control diet (CD), a high fat - high fructose diet alone (WD) or in combination with the administration of 10(8) CFU of L. reuteri (WD-R) for 8 weeks. Body composition, energy balance and plasma lipid profile were evaluated, together with hepatic glucose homeostasis and insulin sensitivity. Metabolic inflammation was also assessed at a whole-body level and in the liver, together with mitochondrial function and oxidative stress.Results: Rats that received the WD and L. reuteri administration exhibited a lower body lipid gain and a higher protein gain, underlying a beneficial effect of the probiotic in counteracting the development of obesity. Moreover, the WD-R rats were protected from the development of inflammation at a whole body and liver level and displayed normal glucose homeostasis and insulin sensitivity, a decreased hepatic lipid deposition and a preserved function of the mitochondrial respiratory chain and redox balance. Conclusions: We demonstrate for the first time that Limosilactobacillus reuteri DSM 17938 has a strong efficacy in preventing the development of the hepatic metabolic derangement elicited by the Western diet administration. These are promising results that open the way for the use of this probiotic as a prevention strategy against the development of diet-related diseases, such as type two diabetes and metabolic syndrome.
C1 [Di Porzio, Angela; Barrella, Valentina; Gatto, Cristina; Cigliano, Luisa; Crescenzo, Raffaella; Iossa, Susanna; Mazzoli, Arianna] Univ Naples Federico II, Dept Biol, Naples, Italy.
   [Spagnuolo, Maria Stefania] Natl Res Council Naples CNR ISPAAM, Inst Anim Prod Syst Mediterranean Environm, Dept Bioagrofood Sci, Naples, Italy.
   [Romano, Ida; Mauriello, Gianluigi] Univ Naples Federico II, Dept Agr Sci, Naples, Italy.
   [Barrella, Valentina; Iossa, Susanna] NBFC, Natl Biodivers Future Ctr, I-90133 Palermo, Italy.
   [Iossa, Susanna; Mazzoli, Arianna] Complesso Univ Monte S Angelo, Dept Biol, Edificio 7,Via Cintia, I-80126 Naples, Italy.
C3 University of Naples Federico II; Consiglio Nazionale delle Ricerche
   (CNR); Istituto Per Il Sistema Produzione Animale In Ambiente
   Mediterraneo (ISPAAM-CNR); University of Naples Federico II; National
   Biodiversity Future Center
RP Iossa, S; Mazzoli, A (corresponding author), Complesso Univ Monte S Angelo, Dept Biol, Edificio 7,Via Cintia, I-80126 Naples, Italy.
EM susanna.iossa@unina.it; arianna.mazzoli@unina.it
RI Spagnuolo, Maria/B-7661-2015; Cigliano, Luisa/AEL-3260-2022; IOSSA,
   Susanna/O-1625-2016; Mauriello, Gianluigi/D-2939-2016
OI DI PORZIO, ANGELA/0000-0003-4614-5267; GATTO,
   CRISTINA/0000-0003-1658-8470; mazzoli, arianna/0000-0003-4096-443X;
   IOSSA, Susanna/0000-0001-6103-718X; Mauriello,
   Gianluigi/0000-0002-6876-6235
FU University of Naples Federico II [RD 2022] [RD 2022]
FX This work was supported by a grant from University of Naples Fed-erico
   II [RD 2022] .
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NR 79
TC 9
Z9 9
U1 2
U2 10
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1756-4646
EI 2214-9414
J9 J FUNCT FOODS
JI J. Funct. Food.
PD OCT
PY 2023
VL 109
AR 105805
DI 10.1016/j.jff.2023.105805
EA SEP 2023
PG 13
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA FK1V6
UT WOS:001145585800001
OA gold
DA 2025-06-11
ER

PT J
AU Dore, L
   Durand, E
   Bonafos, B
   Chaiyut, J
   Vaysse, L
   Liengprayoon, S
   Gaillet, S
   Pessemesse, L
   Lambert, K
   Bertrand-Gaday, C
   Coudray, C
   Sultan, A
   Casas, F
   Feillet-Coudray, C
AF Dore, Laetitia
   Durand, Erwann
   Bonafos, Beatrice
   Chaiyut, Jatuporn
   Vaysse, Laurent
   Liengprayoon, Siriluck
   Gaillet, Sylvie
   Pessemesse, Laurence
   Lambert, Karen
   Bertrand-Gaday, Christelle
   Coudray, Charles
   Sultan, Ariane
   Casas, Francois
   Feillet-Coudray, Christine
TI Preventive nutritional supplementation with furan fatty acid in a DIO
   mouse model increases muscle mass and reduces metabolic disorders
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Article
DE Key Furan fatty acids; Obesity; Insulin sensitivity; Skeletal muscle;
   Liver; Mitochondria
ID HEPATIC GLUCONEOGENESIS; INSULIN-RESISTANCE; PHYSICAL-ACTIVITY;
   RISK-FACTORS; F-ACIDS; FISH; CONSUMPTION; COMPONENT; PROFILE; BLOOD
AB The increase in obesity has become a major global health problem and is associated with numerous metabolic dysfunctions. Furan fatty acids (FuFAs) are minor lipids present in our diet. Recently we showed that FuFA-F2 extracted from Hevea brasiliensis latex stimulates muscle anabolism in mice in vitro and in vivo, mimicking in part physical activity. While skeletal muscle is essential for energy metabolism and is the predominant site of insulin-mediated glucose uptake in the post prandial state, our results suggested that FuFA-F2 could have favorable effects against obesity. The aim of this work was therefore to study whether a preventive nutritional supplementation with FuFA-F2 (40 mg or 110 mg/day/kg of body weight) in a diet-induced obesity (DIO) mouse model may have beneficial effects against obesity and liver and skeletal muscle metabolic dysfunction. We showed that 12 weeks of FuFA-F2 supplementation in DIO mice decreased fat mass, increased lean mass and restored normal energy expenditure. In addition, we found that FuFA-F2 improved insulin sensitivity. We revealed that FuFA-F2 increased muscle mass but had no effect on mitochondrial function and oxidative stress in skeletal muscle. Furthermore, we observed that FuFA-F2 supplementation reduced liver steatosis without impact on mitochondrial function and oxidative stress in liver. Our findings demonstrated for the first time that a preventive nutritional supplementation with a furan fatty acid in DIO mice reduced metabolic disorders and was able to mimic partly the positive effects of physical activity. This study highlights that nutritional FuFA-F2 supplementation could be an effective approach to treat obesity and metabolic syndrome.
C1 [Dore, Laetitia; Bonafos, Beatrice; Gaillet, Sylvie; Pessemesse, Laurence; Bertrand-Gaday, Christelle; Coudray, Charles; Casas, Francois; Feillet-Coudray, Christine] Univ Montpellier, DMEM, INRAE, Montpellier, France.
   [Durand, Erwann] CIRAD, UMR Qualisud, F-34398 Montpellier, France.
   [Durand, Erwann] Univ La Reunion, Inst Agro, IRD, Qualisud,Univ Montpellier,Avignon Univ,CIRAD, Montpellier, France.
   [Vaysse, Laurent] CIRAD, UPR BioWooEB, F-34398 Montpellier, France.
   [Vaysse, Laurent] Univ Montpellier, BioWooEB, CIRAD, Montpellier, France.
   [Chaiyut, Jatuporn; Liengprayoon, Siriluck] Kasetsart Univ, Kasetsart Agr & Agroind Prod Improvement Inst, Bangkok, Thailand.
   [Lambert, Karen] INSERM, U1046, Montpellier, France.
   [Sultan, Ariane; Casas, Francois] Univ Montpellier, Serv Diabet Nutr, PHYMEDEXP, Montpellier, France.
C3 Universite de Montpellier; INRAE; Universite de Montpellier; CIRAD;
   University of La Reunion; Universite de Montpellier; Avignon Universite;
   Institut de Recherche pour le Developpement (IRD); CIRAD; Institut Agro;
   CIRAD; CIRAD; Universite de Montpellier; Kasetsart University; Institut
   National de la Sante et de la Recherche Medicale (Inserm); Universite de
   Montpellier; Institut National de la Sante et de la Recherche Medicale
   (Inserm); Universite de Montpellier
RP Dore, L; Casas, F; Feillet-Coudray, C (corresponding author), Univ Montpellier, DMEM, INRAE, Montpellier, France.
EM francois.casas@inrae.fr; christine.coudray@inrae.fr
RI Lambert, Karen/MJQ-7172-2025; Vaysse, Laurent/AAE-8257-2021;
   BERTRAND-GADAY, Christelle/ABA-8619-2021; Durand, Erwann/ABE-9862-2020
OI BERTRAND-GADAY, Christelle/0000-0003-0461-2402; Francois,
   Casas/0000-0002-5535-8195; Liengprayoon, Siriluck/0000-0001-8309-6981
FU French National Research Institute for Agriculture, Food and Environment
   (INRAE); French Lipid Nutrition Group; Key Initiative Food amp; Health
   of MUSE (Montpellier University of Excellence); Agence Regionale de
   Sante Occitanie
FX This work was supported by the French National Research Institute for
   Agriculture, Food and Environment (INRAE) , by the French Lipid
   Nutrition Group and by the by the Key Initiative Food & Health of MUSE
   (Montpellier University of Excellence) . Laetitia Dore was funded by
   Agence Regionale de Sante Occitanie.
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NR 47
TC 4
Z9 4
U1 2
U2 7
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD AUG
PY 2023
VL 164
AR 114945
DI 10.1016/j.biopha.2023.114945
EA MAY 2023
PG 10
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA J9FP7
UT WOS:001012613400001
PM 37263166
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Watanabe, LM
   Hashimoto, AC
   Torres, DJ
   Berry, MJ
   Seale, LA
AF Watanabe, Ligia M.
   Hashimoto, Ann C.
   Torres, Daniel J.
   Berry, Marla J.
   Seale, Lucia A.
TI Effects of selenium supplementation on diet-induced obesity in mice with
   a disruption of the selenocysteine lyase gene
SO JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
LA English
DT Article
DE Selenium; Selenocysteine lyase; Diet-induced obesity
ID MESSENGER-RNA LEVELS; SELENOPROTEINS; IDENTIFICATION; BIOSYNTHESIS;
   METABOLISM; MECHANISM; PROTEIN; ENZYME
AB BACKGROUND: The amino acid selenocysteine (Sec) is an integral part of selenoproteins, a class of proteins mostly involved in strong redox reactions. The enzyme Sec lyase (SCLY) decomposes Sec into selenide allowing for the recycling of the selenium (Se) atom via the selenoprotein synthesis machinery. We previously demon-strated that disruption of the Scly gene (Scly KO) in mice leads to the development of obesity and metabolic syndrome, with effects on glucose homeostasis, worsened by Se deficiency or a high-fat diet, and exacerbated in male mice. Our objective was to determine whether Se supplementation could ameliorate obesity and restore glucose homeostasis in the Scly KO mice.
   METHODS: Three-weeks old male and female Scly KO mice were fed in separate experiments a diet containing 45 % kcal fat and either sodium selenite or a mixture of sodium selenite and selenomethionine (selenite/SeMet) at moderate (0.25 ppm) or high (0.5-1 ppm) levels for 9 weeks, and assessed for metabolic parameters, oxidative stress and expression of selenoproteins.
   RESULTS: Se supplementation was unable to prevent obesity and elevated epididymal white adipose tissue weights in male Scly KO mice. Serum glutathione peroxidase activity in Scly KO mice was unchanged regardless of sex or dietary Se intake; however, supplementation with a mixture of selenite/SeMet improved oxidative stress biomarkers in the male Scly KO mice.
   CONCLUSION: These results unveil sex- and selenocompound-specific regulation of energy metabolism after the loss of Scly, pointing to a role of this enzyme in the control of whole-body energy metabolism regardless of Se levels.
C1 [Watanabe, Ligia M.; Hashimoto, Ann C.; Torres, Daniel J.; Berry, Marla J.; Seale, Lucia A.] Univ Hawaii Manoa, John A Burns Sch Med, Dept Cell & Mol Biol, Honolulu, HI 96813 USA.
   [Watanabe, Ligia M.] Univ Sao Paulo FMRP USP, Fac Med Ribeirao Preto, Dept Internal Med, Sao Paulo, Brazil.
C3 University of Hawaii System; University of Hawaii Manoa; Universidade de
   Sao Paulo
RP Seale, LA (corresponding author), Univ Hawaii Manoa, John A Burns Sch Med, Dept Cell & Mol Biol, Honolulu, HI 96813 USA.
EM lseale@hawaii.edu
RI Torres, Daniel/ACU-0207-2022; Watanabe, Ligia/AAK-8539-2020; Seale,
   Lucia/AFT-9036-2022
OI Seale, Lucia/0000-0002-0686-7516; Torres, Daniel/0000-0002-4451-712X;
   Moriguchi Watanabe, Ligia/0000-0001-7498-6165
FU National Institutes of Health (NIH) [R01DK047320, U54MD007601, 5544,
   R01DK047320-2251]; Office of the Director (OD) [R01DK047320-2252];
   Office of Dietary Supplements (ODS) [R01DK047320-2252]; Fundacao de
   Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2018/09478 -4]
FX This work was supported by National Institutes of Health (NIH) grants
   R01DK047320 to MJB; U54MD007601 -Subproject 5544 to LAS;
   R01DK047320-2251 to MJB, an Administrative Supplement for Research on
   Dietary Supplements from the Office of the Director (OD) and co-funded
   by the Office of Dietary Supplements (ODS); R01DK047320-2252 to MJB, a
   Research Supplement to Promote Diversity in Health-Related Research and
   fellowship 2018/09478 -4 from Fundacdo de Amparo a Pesquisa do Estado de
   Sao Paulo (FAPESP) to LMW.
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NR 38
TC 13
Z9 13
U1 0
U2 15
PU ELSEVIER GMBH
PI MUNICH
PA HACKERBRUCKE 6, 80335 MUNICH, GERMANY
SN 0946-672X
J9 J TRACE ELEM MED BIO
JI J. Trace Elem. Med. Biol.
PD DEC
PY 2020
VL 62
AR 126596
DI 10.1016/j.jtemb.2020.126596
PG 8
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA OM4WV
UT WOS:000586028000027
PM 32683228
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Trasande, L
   Koshy, TT
   Gilbert, J
   Burdine, LK
   Marmor, M
   Han, XX
   Shao, YZ
   Chemtob, C
   Attina, TM
   Urbina, EM
AF Trasande, Leonardo
   Koshy, Tony T.
   Gilbert, Joseph
   Burdine, Lauren K.
   Marmor, Michael
   Han, Xiaoxia
   Shao, Yongzhao
   Chemtob, Claude
   Attina, Teresa M.
   Urbina, Elaine M.
TI Cardiometabolic profiles of adolescents and young adults exposed to the
   World Trade Center Disaster
SO ENVIRONMENTAL RESEARCH
LA English
DT Article
DE World Trade Center Disaster; Cardiometabolic effects; Dust exposure;
   Traumatic exposure
ID POSTTRAUMATIC-STRESS-DISORDER; GRANULOMATOUS PULMONARY-DISEASE; ARTERIAL
   STIFFNESS; RESPIRATORY HEALTH; METABOLIC SYNDROME; LUNG-FUNCTION; CENTER
   DUST; CHILDREN; OBESITY; QUESTIONNAIRE
AB Background and objective: Few studies have examined the possible cardiometabolic consequences of World Trade Center-related exposures on children who lived and/or attended school near the disaster site. Our objective was to compare cardiometabolic profiles of participants in the World Trade Center Health Registry (WTCHR) with a matched comparison group.
   Methods: We evaluated WTCHR enrollees who resided in New York City and were born between September 11, 1993 and September 10, 2001, and a matched comparison group. We assessed exposure to dust cloud, home dust, as well as traumatic exposure, and associations with blood pressure, arterial wall stiffness, body mass index (BMI), total cholesterol, triglycerides, HDL, and LDL.
   Results: A total of 402 participants completed the study, 222 in the comparison group and 180 in the WTCHR group. In multivariable regression analysis, after adjusting for relevant confounders we detected a weak association between participation in the WTCHR group and lower BMI (-1.12 kg/m(2), 95% CI -2.11, -0.12; p = 0.03), which became non-significant after adjusting for multiple comparisons. With respect to traumatic and psychosocial exposures, the only association that persisted in our multivariable model, below our predefined level of significance, was between post-traumatic stress disorder and higher BMI (2.06 kg/m(2), 95% CI 0.37, 3.74; p = 0.02).
   Conclusions: Our findings do not support an association between self-reported exposures to the WTC disaster and adverse cardiometabolic profile. However, further longitudinal studies may better inform the full extent of WTC-related conditions associated with exposure to the disaster.
C1 [Trasande, Leonardo; Koshy, Tony T.; Gilbert, Joseph; Burdine, Lauren K.; Attina, Teresa M.] NYU, Sch Med, Dept Pediat, 403 East 34th St Rm 115, New York, NY 10016 USA.
   [Trasande, Leonardo; Marmor, Michael; Shao, Yongzhao] NYU, Sch Med, Environm Med, New York, NY USA.
   [Trasande, Leonardo; Marmor, Michael; Han, Xiaoxia; Shao, Yongzhao] NYU, Sch Med, Populat Hlth, New York, NY USA.
   [Marmor, Michael] NYU, Sch Med, Med, New York, NY USA.
   [Chemtob, Claude] NYU, Sch Med, Psychiat, New York, NY USA.
   [Trasande, Leonardo] NYU, Wagner Sch Publ Serv, New York, NY USA.
   [Trasande, Leonardo] NYU, Coll Global Publ Hlth, New York, NY USA.
   [Urbina, Elaine M.] Cincinnati Childrens Hosp Med Ctr, Cincinnati, OH 45229 USA.
   [Urbina, Elaine M.] Univ Cincinnati, Cincinnati, OH USA.
C3 New York University; New York University; New York University; New York
   University; New York University; New York University; New York
   University; Cincinnati Children's Hospital Medical Center; University
   System of Ohio; University of Cincinnati
RP Trasande, L (corresponding author), NYU, Sch Med, Dept Pediat, 403 East 34th St Rm 115, New York, NY 10016 USA.
EM leonardo.trasande@nyumc.org
RI Trasande, Leonardo/ABE-6339-2020; Marmor, Michael/L-9014-2015
OI Marmor, Michael/0000-0001-6605-2661; Trasande,
   Leonardo/0000-0002-1928-597X
FU Centers for Disease Control and Prevention/National Institute of
   Occupational Safety and Health [U010H01394, U010H01714]
FX This research was supported by the Centers for Disease Control and
   Prevention/National Institute of Occupational Safety and Health, through
   cooperative agreements U010H01394 and U010H01714.
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NR 43
TC 13
Z9 14
U1 0
U2 2
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0013-9351
EI 1096-0953
J9 ENVIRON RES
JI Environ. Res.
PD JAN
PY 2018
VL 160
BP 107
EP 114
DI 10.1016/j.envres.2017.09.026
PG 8
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA FP3WL
UT WOS:000417548600013
PM 28972913
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Ohyama, K
   Suzuki, K
AF Ohyama, Kana
   Suzuki, Katsuya
TI Dihydrocapsiate improved age-associated impairments in mice by
   increasing energy expenditure
SO AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
LA English
DT Article
DE dihydrocapsiate; aging; liver steatosis; inflammation; fat oxidation
ID CAPSAICIN ANALOGS CAPSINOIDS; BROWN ADIPOSE-TISSUE; DIET-INDUCED
   OBESITY; CH-19 SWEET; METABOLIC SYNDROME; HEPATIC STEATOSIS; OXIDATIVE
   STRESS; CAPSICUM-ANNUUM; LIVER-DISEASE; C. ELEGANS
AB Metabolic dysfunction is associated with aging and results in age-associated chronic diseases, including type 2 diabetes mellitus, cardiovascular disease, and stroke. Hence, there has been a focus on increasing energy expenditure in aged populations to protect them from age-associated diseases. Dihydrocapsiate (DCT) is a compound that belongs to the capsinoid family. Capsinoids are capsaicin analogs that are found in nonpungent peppers and increase whole body energy expenditure. However, their effect on energy expenditure has been reported only in young populations, and to date the effectiveness of DCT in increasing energy expenditure in aged populations has not been investigated. In this study, we investigated whether DCT supplementation in aged mice improves age-associated impairments. We obtained 5-wk-old and 1-yr-old male C57BL/6J mice and randomly assigned the aged mice to two groups, resulting in a total of three groups: 1) young mice, 2) old mice, and 3) old mice supplemented with 0.3% DCT. After 12 wk of supplementation, blood and tissue samples were collected and analyzed. DCT significantly suppressed age-associated fat accumulation, adipocyte hypertrophy, and liver steatosis. In addition, the DCT treatment dramatically suppressed age-associated increases in hepatic inflammation, immune cell infiltration, and oxidative stress. DCT exerted these suppression effects by increasing energy expenditure linked to upregulation of both the oxidative phosphorylation gene program and fatty acid oxidation in skeletal muscle. These results indicate that DCT efficiently improves age-associated impairments, including liver steatosis and inflammation, in part by increasing energy expenditure via activation of the fat oxidation pathway in skeletal muscle.
C1 [Ohyama, Kana; Suzuki, Katsuya] Ajinomoto Co Inc, Frontier Res Labs, Inst Innovat, Kawasaki Ku, Kawasaki, Kanagawa, Japan.
C3 Ajinomoto Co Inc
RP Ohyama, K (corresponding author), Ajinomoto, Frontier Res Labs, Inst Innovat, Kawasaki, Kanagawa 2108681, Japan.
EM kana_oyama@ajinomoto.com
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NR 63
TC 7
Z9 7
U1 0
U2 2
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0193-1849
EI 1522-1555
J9 AM J PHYSIOL-ENDOC M
JI Am. J. Physiol.-Endocrinol. Metab.
PD NOV
PY 2017
VL 313
IS 5
BP E586
EP E597
DI 10.1152/ajpendo.00132.2017
PG 12
WC Endocrinology & Metabolism; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Physiology
GA FO1FU
UT WOS:000416502900008
PM 28811294
OA Bronze
DA 2025-06-11
ER

PT J
AU Rovira-Llopis, S
   Bañuls, C
   de Marañon, AM
   Diaz-Morales, N
   Jover, A
   Garzon, S
   Rocha, M
   Victor, VM
   Hernandez-Mijares, A
AF Rovira-Llopis, Susana
   Banuls, Celia
   de Maranon, Aranzazu M.
   Diaz-Morales, Noelia
   Jover, Ana
   Garzon, Sandra
   Rocha, Milagros
   Victor, Victor M.
   Hernandez-Mijares, Antonio
TI Low testosterone levels are related to oxidative stress, mitochondrial
   dysfunction and altered subclinical atherosclerotic markers in type 2
   diabetic male patients
SO FREE RADICAL BIOLOGY AND MEDICINE
LA English
DT Article
DE Testosterone; Type 2 diabetes; Cardiovascular risk; Mitochondria;
   Leukocytes
ID MIDDLE-AGED MEN; HORMONE-BINDING GLOBULIN; LEUKOCYTE/ENDOTHELIAL
   CELL-INTERACTIONS; C-REACTIVE PROTEIN; INSULIN-RESISTANCE;
   CARDIOVASCULAR-DISEASE; SERUM TESTOSTERONE; METABOLIC SYNDROME;
   ASSOCIATION; RISK
AB Introduction: Low testosterone levels in men are associated with type 2 diabetes and cardiovascular risk. However, the role of testosterone in mitochondrial function and leukocyte-endothelium interactions is unknown. Our aim was to evaluate the relationship between testosterone levels, metabolic parameters, oxidative stress, mitochondrial function, inflammation and leukocyte-endothelium interactions in type 2 diabetic patients.
   Materials and methods: The study was performed in 280 male type 2 diabetic patients and 50 control subjects. Anthropometric and metabolic parameters, testosterone levels, reactive oxygen species (ROS) production, mitochondrial membrane potential, TNF alpha, adhesion molecules and leukocyte-endothelium cell interactions were evaluated.
   Results: Testosterone levels were lower in diabetic patients. Total and mitochondrial ROS were increased and mitochondrial membrane potential, SOD and GSR expression levels were reduced in diabetic patients. TNFa, ICAM-1 and VCAM-1 levels, leukocyte rolling flux and adhesion were all enhanced in diabetic patients, while rolling velocity was reduced. Testosterone levels correlated negatively with glucose, HOMA-IR, HbA1c, triglycerides, nonHDL-c, ApoB, hs-CRP and AIP, and positively with HDL-c and ApoA1. The multivariable regression model showed that HDL-c, HOMA-IR and age were independently associated with testosterone. Furthermore, testosterone levels correlated positively with membrane potential and rolling velocity and negatively with ROS production, VCAM-1, rolling flux and adhesion.
   Conclusions: Our data highlight that low testosterone levels in diabetic men are related to impaired metabolic profile and mitochondrial function and enhanced inflammation and leukocyte-endothelium cell interaction, which leaves said patients at risk of cardiovascular events.
C1 [Rovira-Llopis, Susana; Banuls, Celia; de Maranon, Aranzazu M.; Diaz-Morales, Noelia; Jover, Ana; Garzon, Sandra; Rocha, Milagros; Victor, Victor M.; Hernandez-Mijares, Antonio] Univ Hosp Doctor Peset FISABIO, Serv Endocrinol & Nutr, Valencia, Spain.
   [Rocha, Milagros; Victor, Victor M.] Univ Valencia, Dept Pharmacol, CIBER Hepat & Digest Dis, CIBER Res Grp CB06 04 0071, Valencia, Spain.
   [Victor, Victor M.] Univ Valencia, Dept Physiol, Valencia, Spain.
   [Hernandez-Mijares, Antonio] Univ Valencia, Dept Med, Valencia, Spain.
C3 CIBER - Centro de Investigacion Biomedica en Red; CIBEREHD; University
   of Valencia; University of Valencia; University of Valencia
RP Victor, VM; Hernandez-Mijares, A (corresponding author), Univ Hosp Doctor Peset, Avda Gaspar Aguilar 90, Valencia 46017, Spain.
EM victor.victor@uv.es; hernandez_antmij@gva.es
RI victor, victor/Q-4843-2019; Martinez de Maranon Peris,
   Aranzazu/H-4399-2017; Banuls, Celia/H-7359-2017; Diaz-Morales,
   Noelia/H-1978-2015; Rocha, Milagros/I-4987-2015; Rovira-Llopis,
   Susana/AAX-8666-2021
OI Martinez de Maranon Peris, Aranzazu/0000-0002-4153-0396; Banuls,
   Celia/0000-0001-8077-7642; Diaz-Morales, Noelia/0000-0003-1657-2700;
   VICTOR, VICTOR/0000-0002-3027-3945; Rocha, Milagros/0000-0003-2923-6546;
   Rovira-Llopis, Susana/0000-0002-8476-5128
FU Carlos III Health Institute, Spain [PI15/1424, PI16/1083, PI16/00301];
   FISABIO, Spain [UGP15-193]; Ministry of Education of the Valencian
   Regional Government [CIBERehd CB06/04/0071, PROMETEO 2014/035,
   GV/2016/169]; European Regional Development Fund (ERDF "A way to build
   Europe"); Ministry of Health of the Valencian Regional Government
   [CES10/030]; Carlos III Health Institute [CPII16/00037, CD14/00043];
   Juan de la Cierva-Formacion contract from the Ministry of Economy and
   Competitiveness, Spain [FJCI-2015-25040]
FX This study was financed by Grants PI15/1424, PI16/1083, PI16/00301, from
   Carlos III Health Institute, Spain UGP15-193, from FISABIO, Spain
   CIBERehd CB06/04/0071, PROMETEO 2014/035, GV/2016/169 from the Ministry
   of Education of the Valencian Regional Government and by the European
   Regional Development Fund (ERDF "A way to build Europe"). V.M.V. and
   M.R. are recipients of contracts from the Ministry of Health of the
   Valencian Regional Government and Carlos III Health Institute,
   (CES10/030 and CPII16/00037, respectively). S.R-L. is recipient of a
   Juan de la Cierva-Formacion contract from the Ministry of Economy and
   Competitiveness, Spain, (FJCI-2015-25040). C.B. is recipient of a Sara
   Borrell contract from Carlos III Health Institute (CD14/00043).
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NR 40
TC 92
Z9 94
U1 0
U2 12
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0891-5849
EI 1873-4596
J9 FREE RADICAL BIO MED
JI Free Radic. Biol. Med.
PD JUL
PY 2017
VL 108
BP 155
EP 162
DI 10.1016/j.freeradbiomed.2017.03.029
PG 8
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA EX7XS
UT WOS:000403463500015
PM 28359952
DA 2025-06-11
ER

PT J
AU Elliot, AJ
   Chapman, BP
AF Elliot, Ari J.
   Chapman, Benjamin P.
TI Socioeconomic Status, Psychological Resources, and Inflammatory Markers:
   Results From the MIDUS Study
SO HEALTH PSYCHOLOGY
LA English
DT Article
DE socioeconomic status; psychological resources; IL-6; CRP; inflammation
ID CORONARY-HEART-DISEASE; C-REACTIVE PROTEIN; SELF-ESTEEM; METABOLIC
   SYNDROME; AFRICAN-AMERICANS; NATIONAL SAMPLE; PHYSICAL HEALTH;
   IMMUNE-SYSTEM; LIFE; STRESS
AB Objective: Our objective was to investigate interactions of psychological resources and socioeconomic status (SES)-as well as potential gender differences and the explanatory role of childhood and adult stress exposures, health behaviors, and negative and positive affect-in predicting markers of systemic inflammation. Method: We utilized a sample of adults from the Midlife Development in the U.S. (MIDUS) study who provided biomarker data (N = 1,152). SES was operationalized as a composite of education, income, and occupational prestige, and the psychological resources construct was operationalized as a latent factor measured with optimism, perceived control, and self-esteem. Linear regression models examined these 2 factors and their interaction in predicting interleukin-6 (IL-6) and C-reactive protein (CRP) measured on average 2 years later, as well as 3-way interactions involving gender and the impact of covariate adjustment. Results: Psychological resources interacted with SES in men (for IL-6: p < .001; for CRP: p = .04) but not in women. In men, greater psychological resources was associated with lower concentrations of IL-6 at lower levels of SES but higher concentrations of both markers at higher levels of SES. The inverse association between resources and IL-6 at low SES was moderately attenuated upon adjustment for negative affect. Conclusion: Socioeconomic status might modulate the linkage between psychological resources and systemic inflammation in men. At lower levels of SES, resources may be related to lower inflammation in part through lower negative affect. Associations with higher inflammation at higher SES add to growing evidence suggesting that adaptive psychological characteristics may be associated with markers of poorer physiological function under certain conditions.
C1 [Elliot, Ari J.; Chapman, Benjamin P.] Univ Rochester, Dept Psychiat, 300 Crittenden Blvd, Rochester, NY 14642 USA.
C3 University of Rochester
RP Elliot, AJ (corresponding author), Univ Rochester, Dept Psychiat, 300 Crittenden Blvd, Rochester, NY 14642 USA.
EM ari_elliot@urmc.rochester.edu
OI Chapman, Benjamin/0000-0002-5170-3131
FU National Institute on Aging [P01-AG020166, R01AG044588]
FX This research was supported by National Institute on Aging Grants
   P01-AG020166 and R01AG044588. Data used for this research was provided
   by the longitudinal study titled "Midlife Development in the U.S."
   (MIDUS), managed by the Institute on Aging, University of Wisconsin.
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NR 59
TC 44
Z9 53
U1 0
U2 73
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 0278-6133
EI 1930-7810
J9 HEALTH PSYCHOL
JI Health Psychol.
PD NOV
PY 2016
VL 35
IS 11
BP 1205
EP 1213
DI 10.1037/hea0000392
PG 9
WC Psychology, Clinical; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology
GA EA2TV
UT WOS:000386448700005
PM 27280368
OA hybrid, Green Accepted
DA 2025-06-11
ER

PT J
AU da Silva, AI
   Braz, GRF
   Silva-Filho, R
   Pedroza, AA
   Ferreira, DS
   de Castro, RM
   Lagranha, C
AF da Silva, Aline Isabel
   Feitoza Braz, Glauber Ruda
   Silva-Filho, Reginaldo
   Pedroza, Anderson Apolonio
   Ferreira, Diorginis Soares
   de Castro, Raul Manhaes
   Lagranha, Claudia
TI Effect of fluoxetine treatment on mitochondrial bioenergetics in central
   and peripheral rat tissues
SO APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
LA English
DT Article
DE central nervous system; skeletal muscle; energy balance; mitochondrial
   metabolism
ID PERMEABILITY TRANSITION PORE; OXIDATIVE STRESS; FOOD-INTAKE;
   ENERGY-METABOLISM; BEHAVIOR; SEROTONIN; COMPLEX; PROTEIN;
   PHOSPHORYLATION; BIOGENESIS
AB Recent investigations have focused on the mitochondrion as a direct drug target in the treatment of metabolic diseases (obesity, metabolic syndrome). Relatively few studies, however, have explicitly investigated whether drug therapies aimed at changing behavior by altering central nervous system (CNS) function affect mitochondrial bioenergetics, and none has explored their effect during early neonatal development. The present study was designed to evaluate the effects of chronic treatment of newborn male rats with the selective serotonin reuptake inhibitor fluoxetine on the mitochondrial bioenergetics of the hypothalamus and skeletal muscle during the critical nursing period of development. Male Wistar rat pups received either fluoxetine (Fx group) or vehicle solution (Ct group) from the day of birth until 21 days of age. At 60 days of age, mitochondrial bioenergetics were evaluated. The Fx group showed increased oxygen consumption in several different respiratory states and reduced production of reactive oxygen species, but there was no change in mitochondrial permeability transition pore opening or oxidative stress in either the hypothalamus or skeletal muscle. We observed an increase in glutathione S-transferase activity only in the hypothalamus of the Fx group. Taken together, our results suggest that chronic exposure to fluoxetine during the nursing phase of early rat development results in a positive modulation of mitochondrial respiration in the hypothalamus and skeletal muscle that persists into adulthood. Such long-lasting alterations in mitochondrial activity in the CNS, especially in areas regulating appetite, may contribute to permanent changes in energy balance in treated animals.
C1 [da Silva, Aline Isabel; de Castro, Raul Manhaes] Univ Fed Pernambuco, Dept Nutr, Programa Posgrad Nutr, Recife, PE, Brazil.
   [da Silva, Aline Isabel; Feitoza Braz, Glauber Ruda; Silva-Filho, Reginaldo; Pedroza, Anderson Apolonio; Ferreira, Diorginis Soares; Lagranha, Claudia] CAV Fed Univ Pernambuco, Lab Biochem & Exercise Biochem, Dept Phys Educ & Sports Sci, Recife, PE, Brazil.
C3 Universidade Federal de Pernambuco
RP Lagranha, C (corresponding author), CAV Fed Univ Pernambuco, Lab Biochem & Exercise Biochem, Dept Phys Educ & Sports Sci, Recife, PE, Brazil.
EM lagranha@hotmail.com
RI Braz, Glauber/D-4811-2016; de Castro, Raul/A-1635-2014
OI da Silva, Aline Isabel/0009-0005-1102-6155; Feitoza Braz, Glauber
   Ruda/0000-0001-6107-5047; Lagranha, Claudia/0000-0001-6883-9476
FU Foundation for Science and Technology of the State of Pernambuco; CAPES
FX The authors are grateful to Anne Deschamps and Prof. Donald F. Sellitti
   for English correction and improvements to the manuscript. We thank the
   Foundation for Science and Technology of the State of Pernambuco for
   financial support and a scholarship to GRFB and CAPES for a scholarship
   to AIS.
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NR 61
TC 27
Z9 28
U1 0
U2 6
PU CANADIAN SCIENCE PUBLISHING
PI OTTAWA
PA 65 AURIGA DR, SUITE 203, OTTAWA, ON K2E 7W6, CANADA
SN 1715-5312
EI 1715-5320
J9 APPL PHYSIOL NUTR ME
JI Appl. Physiol. Nutr. Metab.
PD JUN
PY 2015
VL 40
IS 6
BP 565
EP 574
DI 10.1139/apnm-2014-0462
PG 10
WC Nutrition & Dietetics; Physiology; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics; Physiology; Sport Sciences
GA CJ2PT
UT WOS:000355327700005
PM 25923579
DA 2025-06-11
ER

PT J
AU Liu, JB
   He, J
   Yu, J
   Mao, XB
   Zheng, P
   Huang, ZQ
   Yu, B
   Chen, DW
AF Liu, Jingbo
   He, Jun
   Yu, Jie
   Mao, Xiangbing
   Zheng, Ping
   Huang, Zhiqing
   Yu, Bing
   Chen, Daiwen
TI Birth weight alters the response to postnatal high-fat diet-induced
   changes in meat quality traits and skeletal muscle proteome of pigs
SO BRITISH JOURNAL OF NUTRITION
LA English
DT Article
DE Birth weight; Skeletal muscle; High-fat diet; Pigs; Proteome
ID INTRAUTERINE GROWTH RESTRICTION; HEAT-SHOCK PROTEINS; DEVELOPMENTAL
   ORIGINS; METABOLIC SYNDROME; NEWBORN PIGLETS; BINDING; MECHANISMS;
   EXPRESSION; BEEF; PHOSPHORYLATION
AB Low birth weight (LBW) exerts persistent effects on the growth and development of offspring. The present study was conducted to test the hypothesis that LBW alters the response of pigs to high-fat (HF) diet-induced changes in meat quality and skeletal muscle proteome. Normal-birth weight (NBW) and LBW piglets were fed a control diet or a HF diet from weaning to slaughter at 110kg body weight. Most of the meat quality traits were influenced by LBW. Meat quality analysis revealed that LBW piglets had a greater ability to deposit intramuscular lipids than their heavier littermates when fed a HF diet. Increased shear force, lower pH(45) (min) and drip loss were observed in the skeletal muscle of LBW piglets compared with NBW piglets. Proteomic analysis revealed forty-six differentially expressed proteins in the skeletal muscle of LBW and NBW piglets fed the control diet or HF diet. These proteins play a central role in cell structure and motility, glucose and energy metabolism, lipid metabolism, and cellular apoptosis, as well as stress response. Of particular interest is the finding that LBW altered the response to HF diet-induced changes in the expression of proteins related to stress response (heat shock protein) and glucose and energy metabolism (pyruvate kinase, phosphoglycerate mutase, enolase and triosephosphate isomerase). Taken together, our findings revealed that the HF diet-induced changes in the expression of glucose and energy metabolism-related proteins varied between NBW and LBW piglets, which provides a possible mechanism to explain higher intramuscular fat store in LBW pigs when fed a HF diet.
C1 [Liu, Jingbo; He, Jun; Yu, Jie; Mao, Xiangbing; Zheng, Ping; Huang, Zhiqing; Yu, Bing; Chen, Daiwen] Sichuan Agr Univ, Inst Anim Nutr, Yaan 625014, Sichuan, Peoples R China.
C3 Sichuan Agricultural University
RP Chen, DW (corresponding author), Sichuan Agr Univ, Inst Anim Nutr, 46 Xinkang Rd, Yaan 625014, Sichuan, Peoples R China.
EM dwchen@sicau.edu.cn
RI Huang, Zhiqing/E-8836-2011; He, Jun/G-5896-2010
FU national 973 programme of China [2012CB124701]; earmarked fund for China
   Agriculture Research System [CARS-36]
FX The present study was supported by the national 973 programme of China
   (2012CB124701) and the earmarked fund for China Agriculture Research
   System (CARS-36). The national 973 programme of China and the earmarked
   fund for China Agriculture Research System had no role in the design and
   analysis of the study or in the writing of this article.
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NR 47
TC 16
Z9 16
U1 0
U2 32
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1145
EI 1475-2662
J9 BRIT J NUTR
JI Br. J. Nutr.
PD MAY 28
PY 2014
VL 111
IS 10
BP 1738
EP 1747
DI 10.1017/S0007114513004431
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA AE7JA
UT WOS:000334172400003
PM 24480424
OA Bronze
DA 2025-06-11
ER

PT J
AU De Flora, S
   Izzotti, A
AF De Flora, Silvio
   Izzotti, Alberto
TI Modulation of genomic and postgenomic alterations in noncancer diseases
   and critical periods of life
SO MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
LA English
DT Review
DE Mutation-related diseases; Pregnancy; Perinatal period; Ageing; Stem
   cells; Chemoprevention
ID COVALENT DNA DAMAGE; CIGARETTE-SMOKE; N-ACETYLCYSTEINE; STEM-CELLS;
   MITOCHONDRIAL-DNA; OXIDATIVE STRESS; HAIR FOLLICLE; ATHEROSCLEROTIC
   LESIONS; TRANSPLACENTAL EXPOSURE; INDUCED CLASTOGENICITY
AB Genomic and postgenomic changes are extensively investigated in cancer research. Similar alterations, affecting genome, transcriptome, mirnome and/or proteome end-points, have been detected in a variety of other chronic degenerative diseases, such as atherosclerosis, degenerative heart diseases, chronic obstructive pulmonary diseases, neurological disorders, eye diseases, diabetes, metabolic syndrome skin ageing and alopecia. No generalization can be made due to the myriad of diverse clinical entities classified as chronic degenerative diseases. Moreover, the detection of molecular changes does not automatically imply their causal role. Nevertheless, common mechanisms, such as DNA damage, epigenetic alterations, oxidative stress, and chronic inflammation, in addition to genetic predisposition, are often involved in noncancer diseases. We debate here in more detail the subjects of cardiovascular diseases and of skin diseases. Moreover, we discuss our experimental studies suggesting that genomic and postgenomic changes do also occur during critical periods of life, including the prenatal life, the perinatal period, and ageing. In addition, we comment on the finding that stem-derived cells are more susceptible to molecular damage than more differentiated cells. All these data are viewed in the perspective of preventive medicine. In fact, there is evidence that the genomic and postgenomic alterations occurring not only in several pathological conditions but also in paraphysiological situations that affect critical periods of life can be modulated by means of dietary and pharmacological agents. The discovery that chemopreventive agents are also able to attenuate nucleotide damage in stem-derived cells warrants further studies in view of possible clinical applications. (C) 2008 Elsevier B.V. All rights reserved.
C1 [De Flora, Silvio; Izzotti, Alberto] Univ Genoa, Dept Hlth Sci, I-16132 Genoa, Italy.
C3 University of Genoa
RP De Flora, S (corresponding author), Univ Genoa, Dept Hlth Sci, Via A Pastore 1, I-16132 Genoa, Italy.
EM sdf@unige.it
OI LA MAESTRA, SEBASTIANO/0000-0003-4939-2124; izzotti,
   alberto/0000-0002-8588-0347
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NR 104
TC 7
Z9 7
U1 1
U2 6
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1386-1964
EI 1873-135X
J9 MUTAT RES-FUND MOL M
JI Mutat. Res.-Fundam. Mol. Mech. Mutagen.
PD JUL 10
PY 2009
VL 667
IS 1-2
SI SI
BP 15
EP 26
DI 10.1016/j.mrfmmm.2008.09.010
PG 12
WC Biotechnology & Applied Microbiology; Genetics & Heredity; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Genetics & Heredity; Toxicology
GA 475NI
UT WOS:000268366200003
PM 18948123
DA 2025-06-11
ER

PT J
AU Sade, LE
   Eroglu, S
   Bozbas, H
   Özbiçer, S
   Hayran, M
   Haberal, A
   Müderrisoglu, H
AF Sade, Leyla Elif
   Eroglu, Serpil
   Bozbas, Huseyin
   Ozbicer, Sueleyman
   Hayran, Mutlu
   Haberal, Ayseguel
   Muderrisoglu, Haldun
TI Relation between epicardial fat thickness and coronary flow reserve in
   women with chest pain and angiographically normal coronary arteries
SO ATHEROSCLEROSIS
LA English
DT Article; Proceedings Paper
CT 77th Congress of the European-Atherosclerosis-Society
CY APR 26-29, 2008
CL Istanbul, TURKEY
SP European Atherosclerosis Soc
DE Coronary disease; Microvascular angina; Echocardiography; Epicardial fat
ID SUBEPICARDIAL ADIPOSE-TISSUE; PIGS IN-VIVO; MICROVASCULAR DYSFUNCTION;
   DOPPLER-ECHOCARDIOGRAPHY; METABOLIC SYNDROME; DISEASE; ANGIOGRAMS;
   LESIONS; ANGINA; HEART
AB Objective: A significant proportion of women with angina-like chest pain and angiographically normal coronary arteries have microvascular dysfunction as detected by reduced coronary blood flow reserve (CFR). Classical clinical risk factors of atherosclerosis poorly predict this scenario. We sought to assess whether increased epicardial fat tissue, which is a metabolically active organ, could be associated with impaired CFR in these patients.
   Methods: We enrolled 68 women who underwent coronary angiography and had no obstructive coronary artery disease. Data about classical risk factors, insulin resistance and serum levels of C-reactive protein (CRP) and adiponectine were obtained. Stress tests were evaluated. Coronary flow velocities at baseline and under-induced hyperemia and epicardial fat thickness (EFT) were measured by transthoracic echocardiography within 48 h of angiography. CFR >= 2.0 was considered normal.
   Results: Forty percent of women had reduced CFR suggestive of microvascular dysfunction and 60% had normal CFR. Menopause, hypertension and abnormal stress tests were significantly more prevalent, adiponectine level was significantly decreased, CRP, insulin resistance, and EFT were significantly increased in women with microvascular dysfunction as compared with those without. On multivariate regression analysis EFT emerged as the only independent predictor of microvascular dysfunction (P<0.0001). EFT of >0.45 cm had 85% sensitivity and 75% specificity to detect CFR <2 (P<0.0001). Traditional risk factors for atherosclerosis did not predict women with abnormal microvascular function.
   Conclusions: EFT has the potential to be an additional and easy diagnostic tool for risk stratification of women with chest pain and angiographically normal coronary arteries. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
C1 [Sade, Leyla Elif; Eroglu, Serpil; Bozbas, Huseyin; Ozbicer, Sueleyman; Haberal, Ayseguel; Muderrisoglu, Haldun] Baskent Univ, Dept Cardiol, Fac Med, TR-06490 Ankara, Turkey.
   [Hayran, Mutlu] Hacettepe Univ, Fac Med, Res Off, TR-06100 Ankara, Turkey.
C3 Baskent University; Hacettepe University
RP Sade, LE (corresponding author), Baskent Univ, Dept Cardiol, Fac Med, Cardiol 10,45 Bahcelievler, TR-06490 Ankara, Turkey.
EM elifsade@baskent-ank.edu.tr
RI Hayran, Mutlu/LWZ-9668-2024; Eroglu, Serpil/ABG-1582-2021; ozbicer,
   suleyman/GYQ-8881-2022; Sade, Leyla Elif/AAQ-7583-2021; MUDERRISOGLU,
   IBRAHIM HALDUN/AAG-8233-2020
OI ozbicer, suleyman/0000-0002-2016-0672; Eroglu,
   Serpil/0000-0003-3055-7953; Sade, Leyla Elif/0000-0003-3737-8595;
   MUDERRISOGLU, IBRAHIM HALDUN/0000-0002-9635-6313
CR Baker AR, 2006, CARDIOVASC DIABETOL, V5, DOI 10.1186/1475-2840-5-1
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NR 31
TC 125
Z9 137
U1 0
U2 15
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0021-9150
EI 1879-1484
J9 ATHEROSCLEROSIS
JI Atherosclerosis
PD JUN
PY 2009
VL 204
IS 2
BP 580
EP 585
DI 10.1016/j.atherosclerosis.2008.09.038
PG 6
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Cardiovascular System & Cardiology
GA 460PW
UT WOS:000267200600045
PM 19019370
DA 2025-06-11
ER

PT J
AU Merle, L
   Rastelli, M
   Datiche, F
   Véjux, A
   Jacquin-Piques, A
   Bouret, SG
   Benani, A
AF Merle, Laetitia
   Rastelli, Marialetizia
   Datiche, Frederique
   Vejux, Anne
   Jacquin-Piques, Agnes
   Bouret, Sebastien G.
   Benani, Alexandre
TI Maternal Diet and Vulnerability to Cognitive Impairment in Adulthood:
   Possible Link with Alzheimer's Disease?
SO NEUROENDOCRINOLOGY
LA English
DT Review
DE Maternal diet; Alzheimer's disease; Nutritional programming; Metabolic
   diseases; Gut microbiota
ID HIGH-FAT DIET; DOCOSAHEXAENOIC ACID DHA; SK-N-BE; INSULIN-RESISTANCE;
   OXIDATIVE STRESS; MEDITERRANEAN DIET; GUT MICROBIOTA; HIPPOCAMPAL
   NEUROGENESIS; METABOLIC SYNDROME; ALPHA-TOCOPHEROL
AB Background: Aging is the main risk factor for developing cognitive impairments and associated neurodegenerative diseases. However, environmental factors, including nutritional health, are likely to promote or reduce cognitive impairments and neurodegenerative pathologies. An intricate relationship exists between maternal nutrition and adult eating behavior, metabolic phenotype, and cognitive abilities. Summary: The objective of the present review was to collect available data, suggesting a link between maternal overnutrition and the latter impairment of cognitive functions in the progeny, and to relate this relationship with Alzheimer's disease (AD). Indeed, cognitive impairments are major behavioral signs of AD. We first reviewed studies showing an association between unbalanced maternal diet and cognitive impairments in the progeny in humans and rodent models. Then we looked for cellular and molecular hallmarks which could constitute a breeding ground for AD in those models. With this end, we focused on synaptic dysfunction, altered neurogenesis, neuroinflammation, oxidative stress, and pathological protein aggregation. Finally, we proposed an indirect mechanism linking maternal unbalanced diet and progeny's vulnerability to cognitive impairments and neurodegeneration through promoting metabolic diseases. We also discussed the involvement of progeny's gut microbiota in the maternal diet-induced vulnerability to metabolic and neurodegenerative diseases. Key Messages: Further investigations are needed to fully decipher how maternal diet programs the fetus and infant brain. Addressing this knowledge gap would pave the way to precise nutrition and personalized medicine to better handle cognitive impairments in adulthood.
C1 [Merle, Laetitia; Datiche, Frederique; Vejux, Anne; Benani, Alexandre] Univ Bourgogne, CNRS, Inst Agro, Ctr Sci Gout & Alimentat,INRAE, Dijon, France.
   [Rastelli, Marialetizia] Univ Lille, Lab Dev & Plast Neuroendocrine Brain, Lille Neurosci & Cognit, Inserm,UMR S1172,CHU Lille, Lille, France.
   [Jacquin-Piques, Agnes] Univ Bourgogne, Inst Agro, Ctr Sci Gout & Alimentat, CNRS,INRAE,Dept Clin Neurophysiol,CHU Dijon, F-21000 Dijon, France.
C3 INRAE; Institut Agro; AgroSup Dijon; Centre National de la Recherche
   Scientifique (CNRS); Universite Bourgogne Europe; Universite de Lille;
   CHU Lille; Institut National de la Sante et de la Recherche Medicale
   (Inserm); Universite Bourgogne Europe; CHU Dijon Bourgogne; Institut
   Agro; AgroSup Dijon; Centre National de la Recherche Scientifique
   (CNRS); INRAE
RP Merle, L (corresponding author), Univ Bourgogne, CNRS, Inst Agro, Ctr Sci Gout & Alimentat,INRAE, Dijon, France.
EM laetitia.merle@u-bourgogne.fr
RI Bouret, Sebastien/AAG-7120-2021; JACQUIN-PIQUES, Agnès/AFN-9891-2022;
   Benani, Alexandre/F-4002-2012
OI Rastelli, Marialetizia/0000-0002-4499-978X; Benani,
   Alexandre/0000-0003-2046-0162
FU ANR MicroFlamEAT [ANR-21- CE14-0033]; Agence Nationale de la Recherche
   (ANR) [ANR-21-CE14-0033] Funding Source: Agence Nationale de la
   Recherche (ANR)
FX The study was funded by ANR MicroFlamEAT (ANR-21- CE14-0033) granted to
   A.B.
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NR 194
TC 0
Z9 0
U1 1
U2 1
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0028-3835
EI 1423-0194
J9 NEUROENDOCRINOLOGY
JI Neuroendocrinology
PD MAR
PY 2025
VL 115
IS 2
DI 10.1159/000543499
EA JAN 2025
PG 24
WC Endocrinology & Metabolism; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology
GA 0RO3L
UT WOS:001426757200001
PM 39799941
DA 2025-06-11
ER

PT J
AU Chen, P
   Wang, R
   Lei, JX
   Feng, LH
   Zhou, BH
AF Chen, Peng
   Wang, Rong
   Lei, Jiexin
   Feng, Lihua
   Zhou, Benhong
TI Urolithin B protects mice from diet-induced obesity, insulin resistance,
   and intestinal inflammation by regulating gut microbiota composition
SO FOOD & FUNCTION
LA English
DT Article
ID HIGH-FAT DIET; INTERVENTION
AB The increasing prevalence of obesity and type 2 diabetes (T2D) signifies the failure of conventional treatments for these diseases. The gut microbiota has been proposed as a key player in the pathophysiology of diet-induced T2D. Urolithin B (Uro B), a gut microbiota-derived polyphenol metabolite, exerts several beneficial health effects. In this study, we investigated the metabolic effects of Uro B on high-fat/high-sucrose (HFHS)-fed mice and determined whether its antidiabetic effects are related to the modulation of the gut microbiota. C57BL/6J mice were fed either a chow or HFHS diet. HFHS-fed mice were administered daily with either a vehicle (water) or different doses of Uro B (100 or 200 mg kg-1) for eight weeks. The composition of the gut microbiota was assessed by 16S rRNA sequencing. The results showed that Uro B treatment reduced HFHS-induced weight gain and visceral obesity and decreased liver weight and triglyceride accumulation associated with blunted hepatic oxidative stress and inflammation. Furthermore, Uro B administration improved insulin sensitivity as revealed by improved insulin tolerance, a lower homeostasis model assessment of insulin resistance, and decreased glucose-induced hyperinsulinemia during the oral glucose tolerance test. Uro B treatment was found to lower the intestinal triglyceride content and alleviate intestinal inflammation and oxidative stress. Remarkably, Uro B treatment markedly increased the proportion of the mucin-degrading bacterium Akkermansia in metagenomic samples. In conclusion, Uro B exerts beneficial metabolic effects by alleviating HFHS diet-induced features of metabolic syndrome, which is associated with a proportional increase in the population of Akkermansia spp.
   The increasing prevalence of obesity and type 2 diabetes (T2D) signifies the failure of conventional treatments for these diseases.
C1 [Chen, Peng; Zhou, Benhong] Wuhan Univ, Renmin Hosp, Dept Pharm, Wuhan 430060, Hubei, Peoples R China.
   [Wang, Rong] Wuhan Univ, Renmin Hosp, Nursing Dept, Wuhan 430060, Hubei, Peoples R China.
   [Lei, Jiexin] Wuhan Univ, Renmin Hosp, Dept Endocrinol, Wuhan 430060, Hubei, Peoples R China.
   [Feng, Lihua] Hubei Univ Chinese Med, Coll Pharm, Wuhan, Peoples R China.
C3 Wuhan University; Wuhan University; Wuhan University; Hubei University
   of Chinese Medicine
RP Zhou, BH (corresponding author), Wuhan Univ, Renmin Hosp, Dept Pharm, Wuhan 430060, Hubei, Peoples R China.
EM 2282968908@qq.com
RI Feng, Lihua/E-3839-2016
FU Open Project of the Hubei Key Laboratory of Wudang Local Chinese
   Medicine Research (Hubei University of Medicine) [WDCM2023017]; Open
   Project of the Hubei Key Laboratory [2023KFZZ001]; China International
   Medical Foundation [Z-2021-46-21012023]
FX This work was supported by the Open Project of the Hubei Key Laboratory
   of Wudang Local Chinese Medicine Research (Hubei University of Medicine)
   (WDCM2023017), the Open Project of the Hubei Key Laboratory
   (2023KFZZ001) and China International Medical Foundation
   (Z-2021-46-21012023).
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NR 44
TC 2
Z9 2
U1 2
U2 19
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PD JUL 15
PY 2024
VL 15
IS 14
BP 7518
EP 7533
DI 10.1039/d4fo02545h
EA JUN 2024
PG 16
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA YG9V4
UT WOS:001254136900001
PM 38920000
DA 2025-06-11
ER

PT J
AU Daneshzad, E
   Tehrani, H
   Bellissimo, N
   Azadbakht, L
AF Daneshzad, Elnaz
   Tehrani, Hatav
   Bellissimo, Nick
   Azadbakht, Leila
TI Dietary Total Antioxidant Capacity and Gestational Diabetes Mellitus: A
   Case-Control Study
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Article
ID OXIDATIVE STRESS; METABOLIC SYNDROME; RISK; DISEASE; YOUNG; EXPRESSION;
   ADHERENCE; PEOPLE; ADULTS; WOMEN
AB Background. Elevated oxidative stress status has been reported among pregnant women with gestational diabetes mellitus (GDM). In diabetic condition, glucose and lipid peroxidation, and alteration in antioxidant defense lead to increased free radicals. The objective of this study was to investigate the association between dietary total antioxidant capacity (DTAC) and GDM.Methods. This hospital-based case-control study was conducted in 463 pregnant women (healthy,n=263; GDM,n=200). Anthropometric indices, blood pressure, and biochemical analyses were measured. Dietary intake was assessed by the average of three 24-hour dietary intake records. DTAC was calculated by three indices: ferric reducing ability of plasma (FRAP), total radical-trapping antioxidant parameter (TRAP), and Trolox equivalent antioxidant capacity (TEAC). Multivariable logistic regression was performed to examine the relationship between DTAC and GDM risk in crude and adjusted models.Results. The mean age and BMI were28.33 +/- 6.23years and29.67 +/- 4.73 kg/m(2), respectively. Total energy, protein, and selenium intakes were significantly higher in cases than controls (P<0.05). Moreover, intakes of carbohydrate, vitamins C, B6, and A, manganese, fruits, fruit juices, vegetables, legumes, and FRAP were significantly lower in cases than controls (P<0.05). The risk of gestational diabetes mellitus was 85% lower among those in the highest tertile of FRAP (OR: 0.15; 95% CI: 0.08-0.29). There was no significant association between the risk of GDM and TRAP (OR: 1.62; 95% CI: 0.94-2.79) as well as TEAC (OR: 1.56; 95% CI: 0.89-2.72).Conclusion. Pregnant women who were in the highest tertile of FRAP were at lower risk of GDM. However, larger prospective studies are needed to confirm our findings.
C1 [Daneshzad, Elnaz; Azadbakht, Leila] Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Community Nutr, Tehran, Iran.
   [Tehrani, Hatav] Isfahan Univ Med Sci, Dept Obstet & Gynecol, Esfahan, Iran.
   [Bellissimo, Nick] Ryerson Univ, Sch Nutr, Toronto, ON, Canada.
   [Azadbakht, Leila] Univ Tehran Med Sci, Diabet Res Ctr, Endocrinol & Metab Clin Sci Inst, Tehran, Iran.
   [Azadbakht, Leila] Isfahan Univ Med Sci, Sch Nutr & Food Sci, Dept Community Nutr, Esfahan, Iran.
C3 Tehran University of Medical Sciences; Isfahan University of Medical
   Sciences; Toronto Metropolitan University; Tehran University of Medical
   Sciences; Isfahan University of Medical Sciences
RP Azadbakht, L (corresponding author), Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Community Nutr, Tehran, Iran.; Azadbakht, L (corresponding author), Univ Tehran Med Sci, Diabet Res Ctr, Endocrinol & Metab Clin Sci Inst, Tehran, Iran.; Azadbakht, L (corresponding author), Isfahan Univ Med Sci, Sch Nutr & Food Sci, Dept Community Nutr, Esfahan, Iran.
EM daneshzad@gmail.com; tehranihatav@yahoo.com; nick.bellissimo@gmail.com;
   azadbakhtleila@gmail.com
RI Azadbakht, Leila/N-2801-2018; ghasemi-tehrani, hatav/G-9683-2019;
   Daneshzad, Elnaz/O-3694-2018
OI Bellissimo, Nick/0000-0002-6177-3731; Daneshzad,
   Elnaz/0000-0003-1400-8532
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NR 48
TC 27
Z9 27
U1 0
U2 9
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PD OCT 8
PY 2020
VL 2020
AR 5471316
DI 10.1155/2020/5471316
PG 9
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA OI4BZ
UT WOS:000583227400004
PM 33101589
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Csipo, T
   Fulop, GA
   Lipecz, A
   Tarantini, S
   Kiss, T
   Balasubramanian, P
   Csiszar, A
   Ungvari, Z
   Yabluchanskiy, A
AF Csipo, Tamas
   Fulop, Gabor A.
   Lipecz, Agnes
   Tarantini, Stefano
   Kiss, Tamas
   Balasubramanian, Priya
   Csiszar, Anna
   Ungvari, Zoltan
   Yabluchanskiy, Andriy
TI Short-term weight loss reverses obesity-induced microvascular
   endothelial dysfunction
SO GEROSCIENCE
LA English
DT Article
DE Weight loss; Obesity; Endothelial function; Aging
ID COGNITIVE IMPAIRMENT; OXIDATIVE STRESS; HIGH-FAT; VASCULAR DYSFUNCTION;
   METABOLIC SYNDROME; VISCERAL FAT; DIET; DISEASE; ADULTS; GENES
AB Obesity is one of the major risk factors for cardiovascular diseases and its prevalence is increasing in all age groups, with the biggest impact observed in middle-aged and older adults. A critical mechanism by which obesity promotes vascular pathologies in these patients involves impairment of endothelial function. While endothelial dysfunction in large vessels promotes atherogenesis, obesity-induced microvascular endothelial dysfunction impairs organ perfusion and thereby is causally related to the pathogenesis of ischemic heart disease, chronic kidney disease, intermittent claudication, exercise intolerance, and exacerbates cognitive decline in aging. Reduction of weight via calorie-based diet and exercise in animal models of obesity results in significant improvement of endothelial function both in large vessels and in the microcirculation, primarily due to attenuation of oxidative stress and inflammation. Clinical data on the protective effects of weight loss on endothelial function is limited to studies of flow-mediated dilation assessed in brachial arteries. Currently, there is no guideline on testing the effects of different weight management strategies on microvascular endothelial function in obese patients. Here, we provide proof-of-concept that weight loss-induced improvement of microvascular endothelial function can be reliably assessed in the setting of a geriatric outpatient clinic using a fast, reproducible, non-invasive method: laser speckle contrast imaging-based measurement of endothelium-dependent microvascular responses during post-occlusive reactive hyperemia tests. Our study also provides initial evidence that short-term weight loss induced by consumption of a low-carbohydrate low-calorie diet can reverse microvascular endothelial dysfunction associated with obesity.
C1 [Csipo, Tamas; Fulop, Gabor A.; Lipecz, Agnes; Tarantini, Stefano; Kiss, Tamas; Balasubramanian, Priya; Csiszar, Anna; Ungvari, Zoltan; Yabluchanskiy, Andriy] Univ Oklahoma, Hlth Sci Ctr, Reynolds Oklahoma Ctr Aging, Dept Geriatr Med, 975 NE 10th St,BRC 1315, Oklahoma City, OK 73104 USA.
   [Csipo, Tamas; Fulop, Gabor A.] Univ Debrecen, Fac Med, Div Clin Physiol, Debrecen, Hungary.
   [Lipecz, Agnes] Josa Andras Hosp, Dept Ophthalmol, Nyiregyhaza, Hungary.
   [Csiszar, Anna; Ungvari, Zoltan] Univ Szeged, Dept Med Phys & Informat, Szeged, Hungary.
   [Ungvari, Zoltan] Semmelweis Univ, Dept Pulmonol, Budapest, Hungary.
C3 University of Oklahoma System; University of Oklahoma Health Sciences
   Center; University of Debrecen; Szeged University; Semmelweis University
RP Yabluchanskiy, A (corresponding author), Univ Oklahoma, Hlth Sci Ctr, Reynolds Oklahoma Ctr Aging, Dept Geriatr Med, 975 NE 10th St,BRC 1315, Oklahoma City, OK 73104 USA.
EM andriy-yabluchanskiy@ouhsc.edu
RI Csipo, Tamas/GWR-0012-2022; Ungvari, Zoltan/GZK-8127-2022; Tarantini,
   Stefano/JMQ-7733-2023
OI Kiss, Tamas/0000-0001-5339-5227; Yabluchanskiy,
   Andriy/0000-0002-9648-7161
FU National Institutes of Health (NIH) [R01-AT-006526, R01-AG047879,
   R01-AG038747, R01-NS056218]; Geroscience Training Program in Oklahoma
   (NIH Grant) [T32-AG-052363]; Oklahoina Nathan Shock Center (NIH Grant)
   [3-P30-AG050911-02S1]; Oklahoma Shared Clinical and Translational
   Resources (NIH Grant) [U54-GM-104938]; Oklahoma Center for the
   Advancement of Science and Technology [HR17-070]; College of Medicine
   Alumni Association; Presbyterian Health Foundation; EU
   [EFOP-3.6.1-16-2016-00008]
FX This work was supported by the National Institutes of Health (NIH)
   Grants R01-AT-006526, R01-AG047879, R01-AG038747, and R01-NS056218, the
   Geroscience Training Program in Oklahoma (NIH Grant T32-AG-052363), the
   Oklahoina Nathan Shock Center (NIH Grant 3-P30-AG050911-02S1), the
   Oklahoma Shared Clinical and Translational Resources (NIH Grant
   U54-GM-104938), the Oklahoma Center for the Advancement of Science and
   Technology (HR17-070), the College of Medicine Alumni Association, the
   Presbyterian Health Foundation, and the EU-funded grant
   EFOP-3.6.1-16-2016-00008. The paper was published as part of the
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NR 76
TC 43
Z9 47
U1 0
U2 14
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 2509-2715
EI 2509-2723
J9 GEROSCIENCE
JI GeroScience
PD JUN
PY 2018
VL 40
IS 3
BP 337
EP 346
DI 10.1007/s11357-018-0028-9
PG 10
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA GO5XN
UT WOS:000440106900010
PM 29916025
OA Green Published
DA 2025-06-11
ER

PT J
AU Leite, NRP
   de Medeiros, MS
   Mury, WV
   Matsuura, C
   Perszel, MBM
   Noronha, G
   Brunini, TMC
   Mendes-Ribeiro, AC
AF Pereira Leite, Natalia Rodrigues
   de Medeiros, Mariana Siqueira
   Mury, Wanda Vianna
   Matsuura, Cristiane
   Moss Perszel, Monique Bandeira
   Noronha Filho, Gerson
   Brunini, Tatiana M. C.
   Mendes-Ribeiro, Antonio Claudio
TI Platelet hyperaggregability in obesity: is there a role for nitric oxide
   impairment and oxidative stress?
SO CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
LA English
DT Article
DE cardiovascular disease; nitric oxide; obesity; oxidative stress;
   platelets
ID L-ARGININE TRANSPORT; INSULIN-RESISTANCE; WEIGHT-LOSS; METABOLIC
   SYNDROME; ACTIVATION; WOMEN; ASSOCIATION; SENSITIVITY; HYPERTENSION;
   INFLAMMATION
AB Epidemiological evidence has shown that platelet activation markers are consistently elevated in obesity, contributing to its prothrombotic state. In order to improve the understanding of the regulation of platelet function in obesity, the aim of this study was to investigate the l-arginine-nitric oxide (NO) pathway in obese adults without other cardiovascular risk factor. Seventeen obese (body mass index [BMI] 35.9 +/- 1.0kg/m(2)) and eighteen age-matched normal weight subjects (BMI 22.0 +/- 0.6kg/m(2)) were included in this study. l-arginine influx was measured with incubation of l-[H-3]-arginine. NO synthase (NOS) and arginase activities were determined by the citrulline assay and the conversion of l-[C-14]-arginine to [C-14]-urea, respectively. Cyclic guanosine monophosphate (cGMP) content was evaluated by enzyme-linked immunosorbent assay. In addition, the study analyzed: platelet aggregation; intraplatelet antioxidant enzymes, via superoxide dismutase (SOD) and catalase activities; and systemic levels of l-arginine, fibrinogen, and C-reactive protein (CRP). Obese patients presented a significant decrease of platelet l-arginine influx, NOS activity, and cGMP levels, along with platelet hyperaggregability. On the presence of NO donor, platelet aggregation was similar between the groups. The fibrinogen and CRP systemic levels were significantly higher and SOD activity was reduced in obesity. No significant differences were observed in plasma levels of l-arginine and intraplatelet arginase and catalase activities between groups. The diminished NO bioavailability associated with inflammatory status and impaired enzymatic antioxidant defence may contribute to future cardiovascular complications in obesity.
C1 [Pereira Leite, Natalia Rodrigues; de Medeiros, Mariana Siqueira; Mury, Wanda Vianna; Matsuura, Cristiane; Moss Perszel, Monique Bandeira; Brunini, Tatiana M. C.; Mendes-Ribeiro, Antonio Claudio] Univ Estado Rio De Janeiro, Dept Pharmacol & Psychobiol, Rio De Janeiro, RJ, Brazil.
   [Moss Perszel, Monique Bandeira; Mendes-Ribeiro, Antonio Claudio] Fed Univ State Rio de Janeiro, Dept Physiol Sci, Discipline Pharmacol, Rio De Janeiro, RJ, Brazil.
   [Noronha Filho, Gerson] Univ Estado Rio De Janeiro, Dept Internal Med, Rio De Janeiro, RJ, Brazil.
C3 Universidade do Estado do Rio de Janeiro; Universidade do Estado do Rio
   de Janeiro
RP de Medeiros, MS (corresponding author), Univ Estado Rio De Janeiro, Dept Pharmacol & Psychobiol, Rio De Janeiro, RJ, Brazil.
EM mass_odonto@yahoo.com.br
RI LEITE, NATALIA/KRQ-1455-2024
OI Matsuura, Cristiane/0000-0002-2317-5781
FU FAPERJ; CNPq
FX The authors gratefully acknowledge the support of FAPERJ and CNPq.
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NR 46
TC 13
Z9 13
U1 0
U2 9
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1440-1681
J9 CLIN EXP PHARMACOL P
JI Clin. Exp. Pharmacol. Physiol.
PD AUG
PY 2016
VL 43
IS 8
BP 738
EP 744
DI 10.1111/1440-1681.12589
PG 7
WC Pharmacology & Pharmacy; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Physiology
GA DR5PZ
UT WOS:000379956200002
PM 27145241
DA 2025-06-11
ER

PT J
AU Guo, HH
   Zhong, RM
   Liu, YJ
   Jiang, XW
   Tang, XL
   Li, Z
   Xia, M
   Ling, WH
AF Guo, Honghui
   Zhong, Ruimin
   Liu, Yongji
   Jiang, Xinwei
   Tang, Xilan
   Li, Zhen
   Xia, Min
   Ling, Wenhua
TI Effects of bayberry juice on inflammatory and apoptotic markers in young
   adults with features of non-alcoholic fatty liver disease
SO NUTRITION
LA English
DT Article
DE Apoptosis; Bayberry; Inflammation; Non-alcoholic fatty liver disease;
   Oxidative stress
ID METABOLIC SYNDROME; LIPID-PEROXIDATION; NATURAL-HISTORY; PALMITIC ACID;
   STEATOHEPATITIS; INTERVENTION; INTERLEUKIN-8; INDIVIDUALS; HEPATOCYTES;
   CONSUMPTION
AB Objective: Oxidative stress and inflammation are involved in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Bayberries contain high levels of polyphenols that possess anti-oxidative and anti-inflammatory properties in vitro. The purpose of this study was to investigate whether the consumption of bayberry juice beneficially alters the levels of oxidative, inflammatory, and apoptotic biomarkers in young individuals with features of NAFLD.
   Methods: In this randomized, placebo-controlled, double-blind, crossover study, 44 participants (ages 18-25 y) were given 250 mL of either bayberry juice or placebo twice daily for 4 wk. Several anthropometric characteristics were measured, and fasting blood samples were drawn before and after each intervention period. The levels of plasma glucose, insulin, lipids, and some NAFLD-related biomarkers were determined.
   Results: No significant effects on the anthropometric parameters and the homeostasis model assessment for insulin resistance were observed. Compared with placebo, the consumption of bayberry juice significantly decreased the plasma levels of protein carbonyl groups (P = 0.038), tumor necrosis factor-a (P < 0.001), and interleukin-8 (P = 0.022). The apoptosis markers analysis revealed significant differences between the treatment and the placebo in the levels of tissue polypeptide-specific antigen (P < 0.001) and cytokeratin-18 fragment M30 (P < 0.001).
   Conclusion: The consumption of bayberry juice for a period of 4 wk can protect against NAFLD in young adults by improving the plasma antioxidant status and inhibiting the inflammatory and apoptotic responses that are involved in this disease. (C) 2014 Elsevier Inc. All rights reserved.
C1 [Guo, Honghui; Zhong, Ruimin; Liu, Yongji] Shaoguan Univ, Henry Fok Sch Food Sci & Engn, Dept Nutr, Shaoguan, Peoples R China.
   [Jiang, Xinwei; Tang, Xilan; Li, Zhen; Xia, Min; Ling, Wenhua] Sun Yat Sen Univ, Sch Publ Hlth, Dept Nutr, Guangdong Prov Key Lab Food Nutr & Hlth, Guangzhou 510275, Guangdong, Peoples R China.
C3 Shaoguan University; Sun Yat Sen University
RP Guo, HH (corresponding author), Shaoguan Univ, Henry Fok Sch Food Sci & Engn, Dept Nutr, Shaoguan, Peoples R China.
EM guohh1999@hotmail.com; xiamin@mail.sysu.edu.cn
RI Guo, Honghui/J-6355-2014
OI Guo, Honghui/0000-0001-7837-0392
FU National Natural Science Foundation [81172655]; National Basic Research
   Program (973 Program) [2012CB517506]; Foundation for Qualified Personnel
   in Colleges and Universities in Guangdong Province
FX This work was supported by grants from the National Natural Science
   Foundation (81172655), the National Basic Research Program (973 Program,
   2012CB517506), and the Foundation for Qualified Personnel in Colleges
   and Universities in Guangdong Province (2011-128). This trial was
   registered at clinicaltrials.gov as NCT01707914.
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NR 30
TC 73
Z9 78
U1 1
U2 33
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0899-9007
EI 1873-1244
J9 NUTRITION
JI Nutrition
PD FEB
PY 2014
VL 30
IS 2
BP 198
EP 203
DI 10.1016/j.nut.2013.07.023
PG 6
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 293BZ
UT WOS:000329947700012
PM 24377455
DA 2025-06-11
ER

PT J
AU Attorri, L
   Di Biase, A
   Di Benedetto, R
   Rigato, P
   Di Virgilio, A
   Salvati, S
AF Attorri, Lucilla
   Di Biase, Antonella
   Di Benedetto, Rita
   Rigato, Patrizia
   Di Virgilio, Antonio
   Salvati, Serafina
TI Micronutrient-enriched rapeseed oils reduce cardiovascular disease risk
   factors in rats fed a high-fat diet
SO ATHEROSCLEROSIS
LA English
DT Article
DE Rapeseed oil; Micronutrients; Cardiovascular diseases; Plasma lipids;
   Antioxidant enzymatic activities; High-fat diet; Liver
ID LOW-DENSITY-LIPOPROTEIN; OXIDATIVE STRESS; CANOLA OIL;
   METABOLIC-SYNDROME; VITAMIN-E; PLASMA; PHYTOSTEROLS; LIPIDS; ACIDS;
   ATHEROSCLEROSIS
AB Many epidemiological studies have demonstrated that vegetable food consumption is associated with a reduced risk of cardiovascular diseases. The beneficial effects have been attributed to the content of bioactive molecules present in large quantities in plant food. The main proposal of this study was to evaluate in vivo whether micronutrient-enriched rapeseed oils (optimised oils) obtained using different crushing and refining procedures and characterised by different quantities and qualities of micronutrients, could have any beneficial effect on lipid profile and antioxidant status of plasma and liver. Sprague-Dawley rats were fed a high-fat diet for 4 weeks. The lipid source consisted of 20% optimised rapeseed oils with different quantities and qualities of micronutrients. The control group received traditional refined rapeseed oil. The experimental optimised oils all had a hypolipidaemic effect. In the group fed the highest levels of micronutrients, the reduction in plasma and hepatic triglycerides reached 25% and 17%, respectively, that of cholesterol 20% and 14%, respectively. In plasma, the ferric antioxidant capacity, superoxide dismutase, glutathione peroxidase and reduced glutathione significantly increased and lipid peroxidation decreased in parallel with the enhancement of micronutrients. The same trend was observed in the liver, except for glutathione peroxidase which was not affected by optimised oils. These results indicate that a regular intake of optimised rapeseed oils can help to improve lipid status and prevent oxidative stress, providing evidence that optimised oils could be a functional food with potentially important cardioprotective properties. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
C1 [Attorri, Lucilla; Di Biase, Antonella; Di Benedetto, Rita; Di Virgilio, Antonio; Salvati, Serafina] Ist Super Sanita, Dept Publ Vet Hlth & Food Safety, I-00161 Rome, Italy.
   [Rigato, Patrizia] San Giuseppe Hosp, Dept Pathol, I-00040 Rome, Italy.
C3 Istituto Superiore di Sanita (ISS)
RP Salvati, S (corresponding author), Ist Super Sanita, Dept Publ Vet Hlth & Food Safety, Vle Regina Elena 299, I-00161 Rome, Italy.
EM salvatis@iss.it
RI DI BENEDETTO, RITA/B-3836-2015; ATTORRI, LUCILLA/B-3833-2015; DI BIASE,
   ANTONELLA/B-3834-2015
OI Di Benedetto, Rita/0000-0002-4796-3555
FU European Commission [FOOD - CT-2006-36318]
FX OPTIM'OILS "Valorisation of healthy lipidic micronutrients by optimising
   food processing of edible oils and fats" is a Specific Targeted Research
   Project supported by the thematic priority "Food Quality and Safety" of
   the European Commission 6th Framework Program - Contract no FOOD -
   CT-2006-36318-www.optimoils.com - Contact: a.
   rossignol-castera@iterg.com.
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NR 37
TC 23
Z9 28
U1 0
U2 13
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0021-9150
EI 1879-1484
J9 ATHEROSCLEROSIS
JI Atherosclerosis
PD DEC
PY 2010
VL 213
IS 2
BP 422
EP 428
DI 10.1016/j.atherosclerosis.2010.07.003
PG 7
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 688RM
UT WOS:000284869700014
PM 20678771
DA 2025-06-11
ER

PT J
AU Wolf, EJ
   Miller, MW
   Zhang, R
   Sherva, R
   Harrington, KM
   Fonda, JR
   Daskalakis, NP
   Gaziano, JM
   Logue, MW
AF Wolf, Erika J.
   Miller, Mark W.
   Zhang, Rui
   Sherva, Richard
   Harrington, Kelly M.
   Fonda, Jennifer R.
   Daskalakis, Nikolaos P.
   Gaziano, J. Michael
   Logue, Mark W.
TI No replication of Alzheimer's disease genetics as a moderator of the
   association between combat exposure and PTSD risk in 138,592 combat
   veterans
SO NATURE MENTAL HEALTH
LA English
DT Article
ID POSTTRAUMATIC-STRESS-DISORDER; APOLIPOPROTEIN-E; METABOLIC SYNDROME;
   DEMENTIA; APOE; PREVALENCE; GENOTYPE; ONSET; ETIOLOGY; TAU
AB Large-scale cohort and epidemiological studies suggest that post-traumatic stress disorder (PTSD) confers risk for late-onset Alzheimer's disease and related dementias (ADRD); however, the basis for this association remains unclear. Several prior studies of military veterans have reported that carriers of the apolipoprotein E (APOE) epsilon 4 gene variant are at heightened risk for the development of PTSD following combat exposure, suggesting that PTSD and ADRD may share some genetic risk. Here we designed a cohort study to further examine the hypothesis that ADRD genetic risk also confers risk for PTSD. To do so, we examined APOE epsilon 4 and epsilon 2 genotypes, an Alzheimer's disease polygenic risk score, and other veteran-relevant risk factors for PTSD in age-stratified groups of individuals of European (n = 123,372) and African (n = 15,220) ancestry in the US Department of Veterans Affairs' Million Veteran Program. Analyses revealed no significant main effect associations between the APOE epsilon 4 (or epsilon 2) genotype or the Alzheimer's disease polygenic risk score on PTSD severity or diagnosis. There were also no significant interactions between measures of Alzheimer's disease genetic risk and either combat exposure severity or history of head injury in association with PTSD in any age group. We conclude that the association between PTSD and the primary ADRD genetic risk factor, APOE epsilon 4, that was reported previously was not replicable in this large and relevant dataset. Thus, the epidemiological association between PTSD and ADRD is not likely to be driven by the major genetic factors underlying ADRD risk.
C1 [Wolf, Erika J.; Miller, Mark W.; Zhang, Rui; Logue, Mark W.] VA Boston Healthcare Syst, Natl Ctr PTSD, Behav Sci Div, Boston, MA 02130 USA.
   [Wolf, Erika J.; Miller, Mark W.; Harrington, Kelly M.; Fonda, Jennifer R.; Logue, Mark W.] Boston Univ, Chobanian & Avedisian Sch Med, Dept Psychiat, Boston, MA 02118 USA.
   [Sherva, Richard; Logue, Mark W.] Boston Univ, Chobanian & Avedisian Sch Med, Biomed Genet, Boston, MA 02118 USA.
   [Harrington, Kelly M.; Gaziano, J. Michael] VA Boston Healthcare Syst, Massachusetts Vet Epidemiol Res & Informat Ctr, Boston, MA USA.
   [Fonda, Jennifer R.] VA Boston Healthcare Syst, Translat Res Ctr TBI & Stress Disorders & Geriatr, Educ & Clin Ctr, Boston, MA USA.
   [Fonda, Jennifer R.; Daskalakis, Nikolaos P.] Harvard Med Sch, Dept Psychiat, Boston, MA USA.
   [Daskalakis, Nikolaos P.] McLean Hosp, Belmont, MA USA.
   [Daskalakis, Nikolaos P.] Broad Inst MIT & Harvard, Stanley Ctr Psychiat Res, Cambridge, MA 02142 USA.
   [Gaziano, J. Michael] Harvard Med Sch, Brigham & Womens Hosp, Div Aging, Boston, MA USA.
   [Logue, Mark W.] Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02118 USA.
C3 Harvard University; Harvard University Medical Affiliates; US Department
   of Veterans Affairs; Veterans Health Administration (VHA); VA Boston
   Healthcare System; Boston University; Boston University; Harvard
   University; Harvard University Medical Affiliates; US Department of
   Veterans Affairs; Veterans Health Administration (VHA); VA Boston
   Healthcare System; Harvard University; Harvard University Medical
   Affiliates; US Department of Veterans Affairs; Veterans Health
   Administration (VHA); VA Boston Healthcare System; Harvard University;
   Harvard Medical School; Harvard University; Harvard University Medical
   Affiliates; McLean Hospital; Harvard University; Massachusetts Institute
   of Technology (MIT); Broad Institute; Harvard University; Harvard
   Medical School; Harvard University Medical Affiliates; Brigham & Women's
   Hospital; Boston University
RP Logue, MW (corresponding author), VA Boston Healthcare Syst, Natl Ctr PTSD, Behav Sci Div, Boston, MA 02130 USA.; Logue, MW (corresponding author), Boston Univ, Chobanian & Avedisian Sch Med, Dept Psychiat, Boston, MA 02118 USA.; Logue, MW (corresponding author), Boston Univ, Chobanian & Avedisian Sch Med, Biomed Genet, Boston, MA 02118 USA.; Logue, MW (corresponding author), Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02118 USA.
EM loguem@bu.edu
RI Miller, Mark/G-7322-2011; Fonda, Jennifer/ABG-2890-2021; Daskalakis,
   Nikolaos/B-7930-2014
OI Wolf, Erika/0000-0003-2666-2435; Daskalakis,
   Nikolaos/0000-0003-1660-9112; Logue, Mark/0000-0001-9347-7892
FU This research is based on data from the Million Veteran Program, Office
   of Research and Development, Veterans Health Administration, and was
   supported by VA BLRD grant 1 I01 BX004192 (MVP015). Jennifer R. Fonda
   received funding from the Department of VA C; Million Veteran Program,
   Office of Research and Development, Veterans Health Administration [1
   I01 BX004192, MVP015]; VA BLRD [IK2CX002192-01A2]; Department of VA
   Clinical Science Research and Development Career Development Award
FX This research is based on data from the Million Veteran Program, Office
   of Research and Development, Veterans Health Administration. It was
   supported by VA BLR&D grant 1 I01 BX004192 (MVP015) to M.W.L. and by the
   Department of VA Clinical Science Research and Development Career
   Development Award IK2CX002192-01A2 to J.R.F. The views expressed in this
   article are those of the authors and do not necessarily reflect the
   position or policy of the Department of Veterans Affairs or the US
   government.
CR A Product of the CMS Alliance to Modernize Healthcare Federally Funded Research and Development Center Centers for Medicare & Medicaid Services (CMS), 2015, Assessment A Demographics
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NR 75
TC 0
Z9 0
U1 1
U2 6
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
EI 2731-6076
J9 NAT MENT HEALTH
JI Nat. Ment. Health
PD MAY
PY 2024
VL 2
IS 5
DI 10.1038/s44220-024-00225-1
PG 16
WC Psychiatry
WE Emerging Sources Citation Index (ESCI)
SC Psychiatry
GA R2W1Y
UT WOS:001390106800007
PM 39247144
DA 2025-06-11
ER

PT J
AU Magenis, ML
   Damiani, AP
   Silveira, GD
   Dagostin, LS
   de Marcos, PS
   de Souza, E
   Casagrande, LD
   Longaretti, LM
   Silveira, PCL
   de Andrade, VM
AF Magenis, Marina Lummertz
   Damiani, Adriani Paganini
   Silveira, Gustavo de Bem
   Dagostin, Ligia Salvan
   de Marcos, Pamela Souza
   de Souza, Emanuel
   Casagrande, Laura de Roch
   Longaretti, Luiza Martins
   Lock Silveira, Paulo Cesar
   de Andrade, Vanessa Moraes
TI Metabolic programming in offspring of mice fed fructose during pregnancy
   and lactation
SO JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE
LA English
DT Article
DE Fructose; pregnancy; offspring; genotoxicity; biochemistry
ID DNA-DAMAGE; OXIDATIVE STRESS; DEVELOPMENTAL ORIGINS; MONOSODIUM
   GLUTAMATE; INDUCED DYSLIPIDEMIA; MICRONUCLEUS ASSAY; KEY ROLE; DIET;
   EXPRESSION; CONSUMPTION
AB Fructose (C6H12O6), also known as levulose, is a hexose. Chronic consumption of fructose may be associated with increased intrahepatic fat concentration and the development of insulin resistance as well as an increase in the prevalence of nonalcoholic fatty liver disease and hyperlipidemia during pregnancy. Despite the existence of many studies regarding the consumption of fructose in pregnancy, its effects on fetuses have not yet been fully elucidated. Therefore, the objective of this study was to evaluate the genetic and biochemical effects in offspring (male and female) of female mice treated with fructose during pregnancy and lactation. Pairs of 60-day-old Swiss mice were used and divided into three groups; negative control and fructose, 10%/l and 20%/l doses of fructose groups. After offspring birth, the animals were divided into six groups: P1 and P2 (males and females), water; P3 and P4 (males and females) fructose 10%/l; and P5 and P6 (males and females) fructose 20%/l. At 30 days of age, the animals were euthanized for genetic and biochemical assessments. Female and male offspring from both dosage groups demonstrated genotoxicity (evaluated through comet assay) and oxidative stress (evaluated through nitrite concentration, sulfhydril content and superoxide dismutase activity) in peripheral and brain tissues. In addition, they showed nutritional and metabolic changes due to the increase in food consumption, hyperglycemia, hyperlipidemia, and metabolic syndrome. Therefore, it is suggested that high consumption of fructose by pregnant female is harmful to their offspring. Thus, it is important to carry out further studies and make pregnant women aware of excessive fructose consumption during this period.
C1 [Magenis, Marina Lummertz; Damiani, Adriani Paganini; Dagostin, Ligia Salvan; de Marcos, Pamela Souza; Longaretti, Luiza Martins; de Andrade, Vanessa Moraes] Univ Southern Santa Catarina UNESC, Lab Translat Biomed, Grad Program Hlth Sci, Criciuma, SC, Brazil.
   [Silveira, Gustavo de Bem; Casagrande, Laura de Roch; Lock Silveira, Paulo Cesar] Univ Southern Santa Catarina UNESC, Lab Expt Pathophysiol, Grad Program Hlth Sci, Criciuma, SC, Brazil.
   [de Souza, Emanuel] Univ Southern Santa Catarina UNESC, Course Biomed, Criciuma, SC, Brazil.
C3 Universidade do Sul de Santa Catarina; Universidade do Sul de Santa
   Catarina; Universidade do Sul de Santa Catarina
RP de Andrade, VM (corresponding author), Univ Southern Santa Catarina, Dept Hlth Sci, Lab Translat Biomed, Grad Program Hlth Sci,UNESC, 1105 Univ Rd, BR-88806000 Criciuma, SC, Brazil.
EM vmoraesdeandrade@yahoo.com.br
RI Damiani, Adriani/N-8007-2018; Andrade, Vanessa/F-9623-2012; de Souza,
   Emanuel/H-5938-2013
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NR 54
TC 5
Z9 6
U1 0
U2 3
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 2040-1744
EI 2040-1752
J9 J DEV ORIG HLTH DIS
JI J. Dev. Orig. Health Dis.
PD AUG
PY 2022
VL 13
IS 4
BP 441
EP 454
AR PII S2040174421000519
DI 10.1017/S2040174421000519
EA SEP 2021
PG 14
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA 2U4IR
UT WOS:000761197500001
PM 34503598
DA 2025-06-11
ER

PT J
AU Bahrami, M
   Cheraghpour, M
   Jafarirad, S
   Alavinejad, P
   Asadi, F
   Hekmatdoost, A
   Mohammadi, M
   Yari, Z
AF Bahrami, Mina
   Cheraghpour, Makan
   Jafarirad, Sima
   Alavinejad, Pejman
   Asadi, Fariba
   Hekmatdoost, Azita
   Mohammadi, Mahsa
   Yari, Zahra
TI The effect of melatonin on treatment of patients with non-alcoholic
   fatty liver disease: a randomized double blind clinical trial
SO COMPLEMENTARY THERAPIES IN MEDICINE
LA English
DT Article
DE melatonin; non-alcoholic fatty liver disease; inflammation mediators;
   anthropometry; leptin; adiponectin
ID BLOOD-PRESSURE; METABOLIC SYNDROME; OXIDATIVE STRESS; PLASMA-LEVELS;
   STEATOHEPATITIS; PARAMETERS; ENZYMES; ANTIOXIDANT; TRYPTOPHAN; THERAPY
AB Objectives: Many factors implicated in the pathogenesis of non-alcoholic fatty liver disease (NAFLD) are including oxidative stress, insulin resistance and abnormal production of adipokines. The aim of this clinical trial was to evaluate the effect of melatonin supplement on some important biochemical markers and signs related to NAFLD.
   Design: A randomized double-blind, placebo-controlled, clinical trial.
   Setting: Twenty-four participants in the melatonin group and 21 participants in the placebo group completed the study.
   Intervention: Participants received 6 mg melatonin or placebo daily, 1 h before bedtime. The intervention period was 12 weeks.
   Main outcome measures: Anthropometric measurements, systolic and diastolic blood pressure, liver enzymes, high sensitive C-reactive protein (hs-CRP), fatty liver grade, also leptin and adiponectin serum levels, were measured at the baseline and the end of intervention.
   Results: A significant improvement was observed in weight (p = 0.043), waist circumference (p = 0.027), abdominal circumference (p = 0.043), systolic (p = 0.039), and diastolic (p = 0.015) blood pressure, leptin serum levels (p = 0.032), hs-CRP (p = 0.024), alanine aminotransferase (p = 0.011), aspartate aminotransferase (p = 0.034), also the grade of fatty liver (p = 0.020) in melatonin treated group compared with the placebo.
   Conclusions: Administration of 6 mg/day melatonin had improvement effect on many factors related to NAFLD such as liver enzymes, hs-CRP, anthropometric measurements, blood pressure, leptin serum levels and the grade of fatty liver.
C1 [Bahrami, Mina; Mohammadi, Mahsa] Ahvaz Jundishapur Univ Med Sci, Hyperlipidemia Res Ctr, Ahvaz, Iran.
   [Cheraghpour, Makan] Ahvaz Jundishapur Univ Med Sci, Canc Res Ctr, Ahvaz, Iran.
   [Jafarirad, Sima] Ahvaz Jundishapur Univ Med Sci, Nutr & Metab Dis Res Ctr, POB 61357-15794, Ahvaz, Iran.
   [Jafarirad, Sima] Ahvaz Jundishapur Univ Med Sci, Sch Allied Med Sci, Nutr Dept, Ahvaz, Iran.
   [Alavinejad, Pejman] Ahvaz Jundishapur Univ Med Sci, Res Inst Infect Dis Digest Syst, Ahvaz, Iran.
   [Asadi, Fariba] Ahvaz Jundishapur Univ Med Sci, Sch Med, Dept Radiol, Ahvaz, Iran.
   [Hekmatdoost, Azita; Yari, Zahra] Shahid Beheshti Univ Med Sci, Fac Nutr & Food Technol, Natl Nutr & Food Technol Res Inst, Dept Clin Nutr & Dietet, Tehran, Iran.
C3 Ahvaz Jundishapur University of Medical Sciences (AJUMS); Ahvaz
   Jundishapur University of Medical Sciences (AJUMS); Ahvaz Jundishapur
   University of Medical Sciences (AJUMS); Ahvaz Jundishapur University of
   Medical Sciences (AJUMS); Ahvaz Jundishapur University of Medical
   Sciences (AJUMS); Ahvaz Jundishapur University of Medical Sciences
   (AJUMS); Shahid Beheshti University Medical Sciences
RP Jafarirad, S (corresponding author), Ahvaz Jundishapur Univ Med Sci, Nutr & Metab Dis Res Ctr, POB 61357-15794, Ahvaz, Iran.
EM Jafarirad-s@ajums.ac.ir
RI Yari, Zahra/P-6594-2019; mohammadi, mahsa/JJD-5677-2023; Jafarirad,
   Sima/I-3688-2018; Hekmatdoost, Azita/AGM-6497-2022
OI Cheraghpour, Makan/0000-0003-4459-4528; Jafarirad,
   Sima/0000-0002-3161-5329; Hekmatdoost, Azita/0000-0002-1944-0052; yari,
   zahra/0000-0003-2796-2413
FU Hyperlipidemia Research Center, Ahvaz Jundishapur University of Medical
   Sciences [HLRC-9503]
FX This work was approved by the Hyperlipidemia Research Center, Ahvaz
   Jundishapur University of Medical Sciences (grant number: HLRC-9503).
   The authors greatly thank the patients who participated in the study.
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NR 42
TC 35
Z9 35
U1 1
U2 13
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0965-2299
EI 1873-6963
J9 COMPLEMENT THER MED
JI Complement. Ther. Med.
PD AUG
PY 2020
VL 52
AR 102452
DI 10.1016/j.ctim.2020.102452
PG 7
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA OA1IW
UT WOS:000577549300019
PM 32951715
DA 2025-06-11
ER

PT J
AU Adebiyi, OO
   Adebiyi, OA
   Owira, PMO
AF Adebiyi, O. O.
   Adebiyi, O. A.
   Owira, P. M. O.
TI Naringin improves zidovudine- and stavudine-induced skeletal muscle
   complications in rats
SO HUMAN & EXPERIMENTAL TOXICOLOGY
LA English
DT Article
DE Zidovudine; oxidative stress; naringin; metabolic complications; NRTIs
ID ANTIRETROVIRAL THERAPY; INSULIN-RESISTANCE; MITOCHONDRIAL TOXICITY;
   METABOLIC SYNDROME; WISTAR RATS; HIV; HAART; ANTIOXIDANTS; STRATEGIES;
   APOPTOSIS
AB Chronic use of nucleoside reverse transcriptase inhibitors (NRTIs) in managing human immunodeficiency virus (HIV) infection has been associated with several complications. Available management options for these complications have yielded controversial results, thus the need to urgently find newer alternatives. Naringin, a plant-derived flavonoid, has been shown to possess antioxidant and antiapoptotic properties which can be exploited in managing NRTI-induced complications. This study therefore investigated the effects of naringin on some NRTI-induced complications. Forty-nine rats (200-250 g) were divided into seven groups and were orally treated with stavudine (d4T)-only, d4T + naringin, d4T + vitamin E, zidovudine (AZT)-only, AZT + naringin, AZT + vitamin E, and distilled water, respectively. Drugs were administered once daily for 56 days, and oral glucose tolerance tests conducted on day 54 of the experiments and rats were thereafter sacrificed on day 56 by halothane overdose. Plasma samples and the left gastrocnemius muscles were stored at -80 degrees C for further analysis. There was significant glucose intolerance, insulin resistance, oxidative stress, and apoptosis in the skeletal muscles of AZT- or d4T-only-treated rats. Naringin, however, significantly reduced fasting blood glucose and fasting plasma insulin concentrations, mitigated glucose intolerance, and insulin resistance in addition to reducing malondialdehyde and carbonyl protein concentrations when coadministered with either NRTIs. Furthermore, naringin improved antioxidant enzyme activities, reduced skeletal muscle BCL-2-associated X protein expression, and improved B-cell lymphoma-2 protein expression compared to AZT- or d4T-only-treated rats. Naringin ameliorated AZT- and d4T-induced complications and therefore should be further investigated as a possible nutritional supplement in managing HIV infection.
C1 [Adebiyi, O. O.; Adebiyi, O. A.; Owira, P. M. O.] Univ KwaZulu Natal Westville, Sch Hlth Sci, Discipline Pharmaceut Sci, Dept Pharmacol, ZA-4041 Durban, South Africa.
C3 University of Kwazulu Natal
RP Adebiyi, OO (corresponding author), Univ KwaZulu Natal Westville, Sch Hlth Sci, Discipline Pharmaceut Sci, Dept Pharmacol, ZA-4041 Durban, South Africa.
EM fadebiyi@gmail.com
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NR 50
TC 2
Z9 2
U1 0
U2 8
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0960-3271
EI 1477-0903
J9 HUM EXP TOXICOL
JI Hum. Exp. Toxicol.
PD JAN
PY 2017
VL 36
IS 1
BP 93
EP 105
DI 10.1177/0960327116638726
PG 13
WC Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Toxicology
GA EH4VU
UT WOS:000391769900009
PM 27005762
DA 2025-06-11
ER

PT J
AU Mori, J
   Patel, VB
   Ramprasath, T
   Alrob, OA
   DesAulniers, J
   Scholey, JW
   Lopaschuk, GD
   Oudit, GY
AF Mori, Jun
   Patel, Vaibhav B.
   Ramprasath, Tharmarajan
   Alrob, Osama Abo
   DesAulniers, Jessica
   Scholey, James W.
   Lopaschuk, Gary D.
   Oudit, Gavin Y.
TI Angiotensin 1-7 mediates renoprotection against diabetic nephropathy by
   reducing oxidative stress, inflammation, and lipotoxicity
SO AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
LA English
DT Article
DE angiotensin 1-7; diabetic nephropathy; lipotoxicity; inflammation; ATGL;
   Sirt
ID CHRONIC KIDNEY-DISEASE; INITIATED METABOLIC SYNDROME; PROXIMAL TUBULAR
   CELLS; CONVERTING ENZYME 2; LIPID NEPHROTOXICITY; SIGNAL TRANSDUCER;
   RENAL INJURY; MOUSE MODEL; ACE2; OBESITY
AB The renin-angiotensin system, especially angiotensin II (ANG II), plays a key role in the development and progression of diabetic nephropathy. ANG 1-7 has counteracting effects on ANG II and is known to exert beneficial effects on diabetic nephropathy. We studied the mechanism of ANG 1-7induced beneficial effects on diabetic nephropathy in db/db mice. We administered ANG 1-7 (0.5 mg.kg(-1).day(-1)) or saline to 5-mo-old db/db mice for 28 days via implanted micro-osmotic pumps. ANG 1-7 treatment reduced kidney weight and ameliorated mesangial expansion and increased urinary albumin excretion, characteristic features of diabetic nephropathy, in db/db mice. ANG 1-7 decreased renal fibrosis in db/db mice, which correlated with dephosphorylation of the signal transducer and activator of transcription 3 (STAT3) pathway. ANG 1-7 treatment also suppressed the production of reactive oxygen species via attenuation of NADPH oxidase activity and reduced inflammation in perirenal adipose tissue. Furthermore, ANG 1-7 treatment decreased lipid accumulation in db/db kidneys, accompanied by increased expressions of renal adipose triglyceride lipase (ATGL). Alterations in ATGL expression correlated with increased SIRT1 expression and deacetylation of FOXO1. The upregulation of angiotensin-converting enzyme 2 levels in diabetic nephropathy was normalized by ANG 1-7. ANG 1-7 treatment exerts renoprotective effects on diabetic nephropathy, associated with reduction of oxidative stress, inflammation, fibrosis, and lipotoxicity. ANG 1-7 can represent a promising therapy for diabetic nephropathy.
C1 [Mori, Jun; Alrob, Osama Abo; Lopaschuk, Gary D.] Univ Alberta, Dept Pediat, Edmonton, AB T6G 2B7, Canada.
   [Mori, Jun; Alrob, Osama Abo; Lopaschuk, Gary D.] Univ Alberta, Dept Pharmacol, Edmonton, AB T6G 2B7, Canada.
   [Mori, Jun; Patel, Vaibhav B.; Ramprasath, Tharmarajan; Alrob, Osama Abo; DesAulniers, Jessica; Lopaschuk, Gary D.; Oudit, Gavin Y.] Univ Alberta, Mazankowski Alberta Heart Inst, Edmonton, AB T6G 2B7, Canada.
   [Oudit, Gavin Y.] Univ Alberta, Dept Physiol, Edmonton, AB T6G 2B7, Canada.
   [Mori, Jun; Patel, Vaibhav B.; Ramprasath, Tharmarajan; DesAulniers, Jessica; Oudit, Gavin Y.] Univ Alberta, Div Cardiol, Dept Med, Edmonton, AB T6G 2B7, Canada.
   [Scholey, James W.] Univ Toronto, Dept Med, Div Nephrol, Toronto, ON M5S 1A1, Canada.
C3 University of Alberta; University of Alberta; University of Alberta;
   University of Alberta; University of Alberta; University of Toronto
RP Oudit, GY (corresponding author), Univ Alberta, Mazankowski Alberta Heart Inst, Dept Med, Div Cardiol, 8440 112 St NW, Edmonton, AB T6G 2B7, Canada.
EM gavin.oudit@ualberta.ca
RI Patel, Vaibhav/B-4163-2016; RAMPRASATH, THARMARAJAN/V-5186-2017
OI Patel, Vaibhav/0000-0001-5917-5962; Mori, Jun/0000-0002-1271-1577;
   RAMPRASATH, THARMARAJAN/0000-0002-2115-5875; Abo Alrob,
   Osama/0000-0003-4090-5157
FU HSFC fellowship; AI-HS fellowship; CIHR; Heart and Stroke Foundation of
   Canada
FX J. Mori is a fellow of the Mazankowski Alberta Heart Institute. G. Y.
   Oudit is an Alberta Innovates-Health Solution (AI-HS) Clinician
   Investigator and a Distinguished Clinician-Scientist of the Heart and
   Stroke Foundation of Canada (HSFC) and Canadian Institutes of Health
   Research (CIHR). G. D. Lopashuk. is an AI-HS Scientist. V. B. Patel is
   supported by HSFC and AI-HS fellowships. Research was funded by grants
   to G. Y. Oudit and G. D. Lopashuk from the CIHR and the Heart and Stroke
   Foundation of Canada.
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NR 51
TC 105
Z9 122
U1 2
U2 24
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 1931-857X
EI 1522-1466
J9 AM J PHYSIOL-RENAL
JI Am. J. Physiol.-Renal Physiol.
PD APR
PY 2014
VL 306
IS 8
BP F812
EP F821
DI 10.1152/ajprenal.00655.2013
PG 10
WC Physiology; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology; Urology & Nephrology
GA AF3KD
UT WOS:000334610000003
PM 24553436
DA 2025-06-11
ER

PT J
AU Sánchez-Terrón, G
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   Delgado, J
   Molina, J
   Estévez, M
AF Sanchez-Terron, Guadalup
   Martinez, Remigio
   Delgado, Josue
   Molina, Javier
   Estevez, Mario
TI Hepatoprotective mechanisms of pomegranate bioactives on a murine models
   affected by NAFLD as analysed by MS-based proteomics: The mitochondria
   in the eye of the storm
SO FOOD RESEARCH INTERNATIONAL
LA English
DT Article
DE Fructose; Liver; NAFLD; Proteomics; Punicalagin; Pomegranate
ID HEPATIC STEATOSIS; OXIDATIVE STRESS; FRUCTOSE; METABOLISM; PUNICALAGIN;
   DYSFUNCTION; GLUCOSE
AB Deciphering the mechanisms underlying the direct association between fructose consumption and the onset and progression of non-alcoholic fatty liver disease (NAFLD), as well as the high prevalence of metabolic syndrome (MetS), is of great importance for adopting potential nutritional strategies. Thus, an evaluation of the impact of sustained high fructose consumption on the liver physiology of Wistar rats was made. Moreover, the effectiveness of a dietary pomegranate-derived supplement (P) at counteracting fructose-induced liver injury was also assessed. For unveiling the underlying mechanisms, an untargeted proteomic analysis of the livers from nineteen Wistar rats fed on a basal commercial feed and supplemented with either drinking water (C) (n = 6), 30 % (w/v) fructose in drinking water (F) (n = 7) or 30 % (w/v) fructose solution plus 0.2 % (w/v) P (F +P) (n = 6) was assessed. Fructose intake severely increased the abundance of several energy-production related-proteins, such as fructose-bisphosphate aldolase or fatty acid synthase, among others, as well as diminished the amount of another ones, such as carnitine O-palmitoyl transferase or different subunits of acyl-coenzyme A oxidase. These changes could facilitate mitochondrial disturbances and oxidative stress. Regarding the hepatic proteome of F, P extract restored mitochondrial homeostasis and strengthened endogenous antioxidant mechanisms diminishing the amount of proteins involved in process that could increase the oxidative status, as well as increasing both the quantity of several proteins involved in proteasome functionality, as expressing changes in the amount of certain RNA-splicing related-proteins, regarding F proteome.
C1 [Sanchez-Terron, Guadalup; Estevez, Mario] Univ Extremadura UEX, Meat & Meat Prod Res Inst IPROCAR, TECAL Res Grp, ROR ID 0174shg90, Caceres 10003, Spain.
   [Martinez, Remigio] Univ Cordoba UCO, Anim Hlth Dept, ENZOEM Competit Res Unit,UIC Zoonosis & Emergent D, Anim Hlth & Zoonoses Res Grp GISAZ, Cordoba 14014, Spain.
   [Delgado, Josue] Univ Extremadura UEX, Meat & Meat Prod Res Inst IPROCAR, HISEALI Res Grp, Caceres 10003, Spain.
   [Molina, Javier] Hosp Univ Caceres HUC, Serv Extremeno Salud SES, Gastroenterol & Hepatol, Junta Extremadura, Caceres 10003, Spain.
C3 Universidad de Extremadura; Universidad de Cordoba; Universidad de
   Extremadura
RP Estévez, M (corresponding author), Avda Ciencias s-n, Caceres 10003, Spain.
RI Sánchez-Terrón, Guadalupe/AAE-6455-2019; Martinez Perez,
   Remigio/A-2414-2009; Delgado, Josue/F-8941-2016
OI Martinez Perez, Remigio/0000-0002-5908-9447; Maria Guadalupe, Sanchez
   Terron/0000-0003-0838-3803; Delgado, Josue/0000-0003-4074-981X
FU Junta de Extremadura [IB20103]; Ministry of Science, Innovation and
   Universities [PID2021-126193OB-I00, FPU18/01077]; University of
   Extremadura [UNEX-AE-3394]; University of Cordoba from the Consejeria de
   Transformacion Economica, Industria, Conocimiento y Universidades of the
   Junta de Andalucia Regional Government (Andalucia, Spain)
   [POSTDOC_21_00041, 05yc77b46, 01jem9c82]
FX The study was funded by "Junta de Extremadura" (IB20103), Ministry of
   Science, Innovation and Universities (grant:
   MCIN/AEI/10.13039/501100011033; project: PID2021-126193OB-I00; Guadalupe
   Sanchez grant: FPU18/01077) and the University of Extremadura
   (UNEX-AE-3394) . Remigio Martinez was supported by a postdoctoral
   contract (POSTDOC_21_00041) at the University of Cordoba (ROR code
   05yc77b46) from the Consejeria de Transformacion Economica, Industria,
   Conocimiento y Universidades of the Junta de Andalucia (ROR code
   01jem9c82) Regional Government (Andalucia, Spain) .
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NR 61
TC 1
Z9 1
U1 3
U2 7
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0963-9969
EI 1873-7145
J9 FOOD RES INT
JI Food Res. Int.
PD SEP
PY 2024
VL 192
AR 114769
DI 10.1016/j.foodres.2024.114769
EA JUL 2024
PG 13
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA ZE3P3
UT WOS:001273583100001
PM 39147495
OA hybrid
DA 2025-06-11
ER

PT J
AU Saigo, Y
   Sasase, T
   Tohma, M
   Uno, K
   Shinozaki, Y
   Maekawa, T
   Sano, R
   Miyajima, K
   Ohta, T
AF Saigo, Yasuka
   Sasase, Tomohiko
   Tohma, Marika
   Uno, Kinuko
   Shinozaki, Yuichi
   Maekawa, Tatsuya
   Sano, Ryuhei
   Miyajima, Katsuhiro
   Ohta, Takeshi
TI High-Cholesterol Diet in Combination With Hydroxypropyl-β-Cyclodextrin
   Induces NASH-Like Disorders in the Liver of Rats
SO PHYSIOLOGICAL RESEARCH
LA English
DT Article
DE NAFLD; NASH; Cholesterol; Hydroxypropyl-beta-cyclodextrin
ID FARNESOID-X-RECEPTOR; NONALCOHOLIC STEATOHEPATITIS; HEPATIC-LESIONS;
   DISEASE; ACID; PATHOGENESIS; REGULATOR; MODEL
AB Non-alcoholic fatty liver disease (NAFLD) is a general term for fatty liver disease not caused by viruses or alcohol. Fibrotic hepatitis, cirrhosis, and hepatocellular carcinoma can develop. The recent increase in NAFLD incidence worldwide has stimulated drug development efforts. However, there is still no approved treatment. This may be due in part to the fact that non-alcoholic steatohepatitis (NASH) pathogenesis is very complex, and its mechanisms are not well understood. Studies with animals are very important for understanding the pathogenesis. Due to the close association between the establishment of human NASH pathology and metabolic syndrome, several animal models have been reported, especially in the context of overnutrition. In this study, we investigated the induction of NASH-like pathology by enhancing cholesterol absorption through treatment with hydroxypropyl-beta-cyclodextrin ( CDX). Female Sprague-Dawley rats were fed a normal diet with normal water (control group); a high-fat (60 kcal%), cholesterol (1.25 %), and cholic acid (0.5 %) diet with normal water (HFCC group); or HFCC diet with 2 % CDX water (HFCC+CDX group) for 16 weeks. Compared to the control group, the HFCC and HFCC+CDX groups showed increased blood levels of total cholesterol, aspartate aminotransferase, and alanine aminotransferase. At autopsy, parameters related to hepatic lipid synthesis, oxidative stress, inflammation, and fibrosis were elevated, suggesting the development of NAFLD/NASH. Elevated levels of endoplasmic reticulum stress-related genes were evident in the HFCC+CDX group. In the novel rat model, excessive cholesterol intake and accelerated absorption contributed to NAF LD/NASH pathogenesis.
C1 [Saigo, Yasuka; Sasase, Tomohiko; Shinozaki, Yuichi; Maekawa, Tatsuya; Sano, Ryuhei] Japan Tobacco Inc, Cent Pharmaceut Res Inst, Biol Pharmacol Res Labs, Takatsuki Res Ctr, 1-1 Murasaki Cho, Takatsuki, Osaka 5691125, Japan.
   [Saigo, Yasuka; Sasase, Tomohiko; Shinozaki, Yuichi; Ohta, Takeshi] Kyoto Univ, Grad Sch Agr, Lab Anim Physiol & Funct Anat, Kyoto, Japan.
   [Tohma, Marika; Uno, Kinuko; Sano, Ryuhei; Miyajima, Katsuhiro] Tokyo Univ Agr, Fac Appl Biosci, Dept Nutr Sci & Food Safety, Tokyo, Japan.
C3 Japan Tobacco Inc.; Kyoto University; Tokyo University of Agriculture
RP Sasase, T (corresponding author), Japan Tobacco Inc, Cent Pharmaceut Res Inst, Biol Pharmacol Res Labs, Takatsuki Res Ctr, 1-1 Murasaki Cho, Takatsuki, Osaka 5691125, Japan.
EM tomohiko.sasase@jt.com
RI Yuichi, Shinozaki/AAO-5953-2021
OI Maekawa, Tatsuya/0000-0001-7871-4503
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NR 35
TC 4
Z9 4
U1 1
U2 5
PU ACAD SCIENCES CZECH REPUBLIC, INST PHYSIOLOGY
PI PRAGUE 4
PA VIDENSKA 1083, PRAGUE 4 142 20, CZECH REPUBLIC
SN 0862-8408
EI 1802-9973
J9 PHYSIOL RES
JI Physiol. Res.
PD JUN
PY 2023
VL 72
IS 3
BP 371
EP 382
DI 10.33549/physiolres.934981
PG 12
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA M6WR4
UT WOS:001031605200009
PM 37449749
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Dewanjee, S
   Vallamkondu, J
   Kalra, RS
   Chakraborty, P
   Gangopadhyay, M
   Sahu, R
   Medala, V
   John, A
   Reddy, PH
   De Feo, V
   Kandimalla, R
AF Dewanjee, Saikat
   Vallamkondu, Jayalakshmi
   Kalra, Rajkumar Singh
   Chakraborty, Pratik
   Gangopadhyay, Moumita
   Sahu, Ranabir
   Medala, Vijaykrishna
   John, Albin
   Reddy, P. Hemachandra
   De Feo, Vincenzo
   Kandimalla, Ramesh
TI The Emerging Role of HDACs: Pathology and Therapeutic Targets in
   Diabetes Mellitus
SO CELLS
LA English
DT Review
DE diabetes mellitus; glucose metabolism; histone deacetylase; HDACs;
   histone deacetylase inhibitor; HDACi; insulin release; sirtuins; sirtuin
   activaton
ID HISTONE DEACETYLASE INHIBITORS; IMPROVES GLUCOSE-TOLERANCE; PANCREATIC
   BETA-CELLS; RETINAL ENDOTHELIAL-CELLS; CYTOKINE-INDUCED TOXICITY;
   OXIDATIVE STRESS; SKELETAL-MUSCLE; EPIGENETIC REGULATION;
   INSULIN-RESISTANCE; MOUSE MODEL
AB Diabetes mellitus (DM) is one of the principal manifestations of metabolic syndrome and its prevalence with modern lifestyle is increasing incessantly. Chronic hyperglycemia can induce several vascular complications that were referred to be the major cause of morbidity and mortality in DM. Although several therapeutic targets have been identified and accessed clinically, the imminent risk of DM and its prevalence are still ascending. Substantial pieces of evidence revealed that histone deacetylase (HDAC) isoforms can regulate various molecular activities in DM via epigenetic and post-translational regulation of several transcription factors. To date, 18 HDAC isoforms have been identified in mammals that were categorized into four different classes. Classes I, II, and IV are regarded as classical HDACs, which operate through a Zn-based mechanism. In contrast, class III HDACs or Sirtuins depend on nicotinamide adenine dinucleotide (NAD(+)) for their molecular activity. Functionally, most of the HDAC isoforms can regulate beta cell fate, insulin release, insulin expression and signaling, and glucose metabolism. Moreover, the roles of HDAC members have been implicated in the regulation of oxidative stress, inflammation, apoptosis, fibrosis, and other pathological events, which substantially contribute to diabetes-related vascular dysfunctions. Therefore, HDACs could serve as the potential therapeutic target in DM towards developing novel intervention strategies. This review sheds light on the emerging role of HDACs/isoforms in diabetic pathophysiology and emphasized the scope of their targeting in DM for constituting novel interventional strategies for metabolic disorders/complications.
C1 [Dewanjee, Saikat; Chakraborty, Pratik] Jadavpur Univ, Dept Pharmaceut Technol, Adv Pharmacognosy Res Lab, Kolkata 700032, W Bengal, India.
   [Vallamkondu, Jayalakshmi] Natl Inst Technol, Warangal 506004, Telangana, India.
   [Kalra, Rajkumar Singh] Natl Inst Adv Ind Sci & Technol, AIST INDIA DAILAB, Higashi 1-1-1, Tsukuba, Ibaraki 3058565, Japan.
   [Gangopadhyay, Moumita] ADAMAS Univ, Sch Life Sci & Biotechnol, Kolkata 700126, W Bengal, India.
   [Sahu, Ranabir] Univ North Bengal, Dept Pharmaceut Technol, Darjeeling 734013, W Bengal, India.
   [Medala, Vijaykrishna; Kandimalla, Ramesh] CSIR Indian Inst Technol, Appl Biol, Uppal Rd, Hyderabad 500007, W Bengal, India.
   [John, Albin; Reddy, P. Hemachandra] Texas Tech Univ, Hlth Sci Ctr, Internal Med, Lubbock, TX 79430 USA.
   [Reddy, P. Hemachandra] Texas Tech Univ, Hlth Sci Ctr, Neurosci & Pharmacol, Lubbock, TX 79430 USA.
   [Reddy, P. Hemachandra] Texas Tech Univ, Hlth Sci Ctr, Sch Med, Neurol Dept, Lubbock, TX 79430 USA.
   [Reddy, P. Hemachandra] Texas Tech Univ, Hlth Sci Ctr, Grad Sch Biomed Sci, Publ Hlth Dept, Lubbock, TX 79430 USA.
   [Reddy, P. Hemachandra] Texas Tech Univ, Hlth Sci Ctr, Sch Hlth Profess, Dept Speech Language & Hearing Sci, Lubbock, TX 79430 USA.
   [De Feo, Vincenzo] Univ Salerno, Dept Pharm, I-84084 Fisciano, Italy.
   [Kandimalla, Ramesh] Kakatiya Med Coll, Dept Biochem, Warangal 506007, Telangana, India.
   [Kalra, Rajkumar Singh] Grad Univ, Okinawa Inst Sci & Technol, Immune Signal Unit, 1919-1 Tancha, Onna, Okinawa 9040495, Japan.
C3 Jadavpur University; National Institute of Technology (NIT System);
   National Institute of Technology Warangal; National Institute of
   Advanced Industrial Science & Technology (AIST); University of North
   Bengal; Texas Tech University System; Texas Tech University Health
   Sciences Center Lubbock; Texas Tech University System; Texas Tech
   University Health Sciences Center Lubbock; Texas Tech University System;
   Texas Tech University Health Sciences Center Lubbock; Texas Tech
   University System; Texas Tech University Health Sciences Center Lubbock;
   Texas Tech University System; Texas Tech University Health Sciences
   Center Lubbock; University of Salerno; Kakatiya Medical College; Okinawa
   Institute of Science & Technology Graduate University
RP Dewanjee, S (corresponding author), Jadavpur Univ, Dept Pharmaceut Technol, Adv Pharmacognosy Res Lab, Kolkata 700032, W Bengal, India.; Kandimalla, R (corresponding author), CSIR Indian Inst Technol, Appl Biol, Uppal Rd, Hyderabad 500007, W Bengal, India.; De Feo, V (corresponding author), Univ Salerno, Dept Pharm, I-84084 Fisciano, Italy.; Kandimalla, R (corresponding author), Kakatiya Med Coll, Dept Biochem, Warangal 506007, Telangana, India.
EM saikat.dewanjee@jadavpuruniversity.in; vlakshmij@gmail.com;
   rajkumar-singh@oist.jp; pratik.chakraborty88@yahoo.com;
   gangopadhyaymoumita75@gmail.com; ranaju4u@yahoo.co.in;
   vijaykrishna079@gmail.com; Albin.John@ttuhsc.edu;
   hemachandra.reddy@ttuhsc.edu; defeo@unisa.it;
   ramesh.kandimalla@gmail.com
RI De Feo, Vincenzo/AAF-2293-2019; Sahu, Ranabir/AAT-6543-2021; Kandimalla,
   Ramesh/O-4047-2017; Dewanjee, Saikat/U-9778-2017; Vallamkondu,
   Jayalakshmi/B-1830-2017; Kalra, Rajkumar/L-6944-2018; Chakraborty,
   Pratik/KSM-0591-2024
OI Vallamkondu, Jayalakshmi/0000-0002-5259-6286; Kalra,
   Rajkumar/0000-0002-8181-457X; Reddy, P. Hemachandra/0000-0002-9560-9948;
   Dewanjee, Saikat/0000-0001-9085-4226; Sahu, Dr.
   Ranabir/0000-0002-2229-1019; Chakraborty, Pratik/0000-0002-7880-7854
FU Council of Scientific and Industrial Research, New Delhi, India
   [02(0275)/16/EMR-II]; DBT-India [BT/RLF/Re-entry/22/2016,
   102/IFD/SAN/1117/2018-19]
FX The authors are thankful to the Council of Scientific and Industrial
   Research, New Delhi, India, for awarding research project (grant number
   02(0275)/16/EMR-II) to Saikat Dewanjee. Authors sincerely acknowledge
   Jadavpur University, India, CSIR-Indian Institute of Chemical
   Technology, Hyderabad, India, for providing necessary facilities, and
   DBT-India for providing Ramalingaswami Re-entry Fellowship to Ramesh
   Kandimalla (RK) for the period of 2018-2023 (No. BT/RLF/Re-entry/22/2016
   and SAN.No. 102/IFD/SAN/1117/2018-19).
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NR 334
TC 40
Z9 42
U1 0
U2 20
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2073-4409
J9 CELLS-BASEL
JI Cells
PD JUN
PY 2021
VL 10
IS 6
AR 1340
DI 10.3390/cells10061340
PG 42
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA SX6QJ
UT WOS:000665326700001
PM 34071497
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Bartoli, F
   Trotta, G
   Crocamo, C
   Malerba, M
   Clerici, M
   Carrà, G
AF Bartoli, Francesco
   Trotta, Giulia
   Crocamo, Cristina
   Malerba, Maria Rosaria
   Clerici, Massimo
   Carra, Giuseppe
TI Antioxidant uric acid in treated and untreated subjects with major
   depressive disorder: a meta-analysis and meta-regression
SO EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
LA English
DT Article
DE Major depressive disorder; Uric acid; Antidepressive agents;
   Meta-analysis
ID TERM ANTIDEPRESSANT TREATMENT; SEVERE MENTAL-ILLNESS; BIPOLAR DISORDER;
   OXIDATIVE STRESS; METABOLIC SYNDROME; PEROXYNITRITE SCAVENGER; MOOD
   DISORDERS; SYSTEM; SCHIZOPHRENIA; INFLAMMATION
AB Pathophysiological mechanisms of major depressive disorder (MDD) seem to be associated with oxidative stress pathways and altered purinergic metabolism. We conducted a systematic review and meta-analysis to estimate if subjects with MDD might have reduced levels of antioxidant uric acid, considering also potential influence of antidepressant treatment. We searched the main Electronic Databases, identifying 14 studies that met our inclusion criteria. Meta-analyses were carried out generating pooled Hedges' g and mean differences (MDs), using random-effects models. Heterogeneity across studies and risk of publication bias were estimated using standard methods. Relevant sensitivity and meta-regression analyses were conducted. Subjects with MDD had levels of uric acid lower than healthy controls (Hedges' g = -0.30; p = 0.003). Overall between-study heterogeneity was high (I (2) = 76.3%). The effect was significant among studies including drug na < ve/free MDD individuals (Hedges' g = -0.55; p = 0.023), but not among those involving treated subjects (Hedges' g = -0.15; p = 0.062). Relevant quality- and heterogeneity-based sensitivity analyses, as well as meta-regressions, confirmed these findings. In addition, uric acid levels significantly, though inconsistently (I (2) = 79.2%), increased after treatment (MD = +0.71 mg/dL; p < 0.001), regardless of follow-up duration (p = 0.518). Our meta-analysis shows that subjects with MDD have lower levels of uric acid. Since antidepressant treatment seems to influence this association, our findings support the hypothesis that uric acid levels may represent a state marker of MDD. Nevertheless, the potential role of additional factors that might clarify the nature of this association deserves further research.
C1 [Bartoli, Francesco; Trotta, Giulia; Crocamo, Cristina; Malerba, Maria Rosaria; Clerici, Massimo; Carra, Giuseppe] Univ Milano Bicocca, Dept Med & Surg, Via Cadore 48, I-20900 Monza, Italy.
   [Carra, Giuseppe] UCL, Div Psychiat, London, England.
C3 University of Milano-Bicocca; University of London; University College
   London
RP Bartoli, F (corresponding author), Univ Milano Bicocca, Dept Med & Surg, Via Cadore 48, I-20900 Monza, Italy.
EM f.bartoli@campus.unimib.it
RI Clerici, Massimo/U-3074-2019; Crocamo, Cristina/I-4355-2019; Carra,
   Giuseppe/C-6091-2012; Crocamo, Cristina/B-5404-2014; Dakanalis Antonios
   Ntakanales, MD, MSc, PsyD, PhD, FNASc, Antonios/I-5105-2013; Bartoli,
   Francesco/K-5755-2016
OI Clerici, Massimo/0000-0001-8769-6474; Carra,
   Giuseppe/0000-0002-6877-6169; Crocamo, Cristina/0000-0002-2979-2107;
   Dakanalis Antonios Ntakanales, MD, MSc, PsyD, PhD, FNASc,
   Antonios/0000-0002-2328-3862; Bartoli, Francesco/0000-0003-2612-4119
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NR 51
TC 52
Z9 53
U1 2
U2 22
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0940-1334
EI 1433-8491
J9 EUR ARCH PSY CLIN N
JI Eur. Arch. Psych. Clin. Neurosci.
PD MAR
PY 2018
VL 268
IS 2
BP 119
EP 127
DI 10.1007/s00406-017-0817-7
PG 9
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA FV9AD
UT WOS:000424878200003
PM 28620773
DA 2025-06-11
ER

PT J
AU Liu, C
   Zhou, MS
   Li, Y
   Wang, AM
   Chadipiralla, K
   Tian, RX
   Raij, L
AF Liu, Chang
   Zhou, Ming-Sheng
   Li, Yao
   Wang, Aimei
   Chadipiralla, Kiranmai
   Tian, Runxia
   Raij, Leopoldo
TI Oral nicotine aggravates endothelial dysfunction and vascular
   inflammation in diet-induced obese rats: Role of macrophage TNFα
SO PLOS ONE
LA English
DT Article
ID SALT-SENSITIVE HYPERTENSION; LOW-DENSITY-LIPOPROTEIN; NITRIC-OXIDE
   SYNTHASE; NECROSIS-FACTOR-ALPHA; INCREASED OXIDATIVE STRESS; TYPE-2
   DIABETIC MICE; ACETYLCHOLINE-RECEPTOR; INSULIN-RESISTANCE;
   CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME
AB Obesity and cigarette smoke are major cardiovascular (CV) risk factors and, when coexisting in the same individuals, have additive/synergistic effects upon CVD. We studied the mechanisms involved in nicotine enhancement of CVD in Sprague Dawley rats with diet-induced obesity. The rats were fed either a high fat (HFD) or normal rat chow diet with or without nicotine (100 mg/L in drinking water) for 20 weeks. HFD rats developed central obesity, increased systolic blood pressure (SBP), aortic superoxide (O-2(-)) production, and impaired endothelial nitric oxide synthase (eNOS) and endothelium-dependent relaxation to acetylcholine (EDR). Nicotine further increased SBP, O-2(-) and impaired eNOS and EDR in obese rats. In the peritoneal macrophages from obese rats, tumor necrosis factor (TNF)alpha, interleukin 1 beta and CD36 were increased, and were further increased in nicotine-treated obese rats. Using PCR array we found that 3 of 84 target proinflammatory genes were increased by 2-4 fold in the aorta of obese rats, 11 of the target genes were further increased in nicotine-treated obese rats. HUVECs, incubated with conditioned medium from the peritoneal macrophages of nicotine treated-obese rats, exhibited reduced eNOS and increased NADPH oxidase subunits gp91phox and p22phox expression. Those effects were partially prevented by adding anti-TNF alpha antibody to the conditioned medium. Our results suggest that nicotine aggravates the CV effects of diet-induced obesity including the oxidative stress, vascular inflammation and endothelial dysfunction. The underlying mechanisms may involve in targeting endothelium by enhancement of macrophage-derived TNF alpha.
C1 [Liu, Chang] Jinzhou Med Univ, Affiliated Hosp 1, Dept Endocrinol, Jinzhou, Peoples R China.
   [Zhou, Ming-Sheng] Shenyang Med Univ, Dept Physiol, Shenyang, Liaoning, Peoples R China.
   [Zhou, Ming-Sheng; Li, Yao; Wang, Aimei] Jinzhou Med Univ, Dept Physiol, Jinzhou, Peoples R China.
   [Chadipiralla, Kiranmai; Tian, Runxia; Raij, Leopoldo] Univ Miami, Miller Sch Med, Miami VAMC, Nephrol Hypertens Sect, Miami, FL 33136 USA.
C3 Jinzhou Medical University; Shenyang Medical College; Jinzhou Medical
   University; University of Miami
RP Zhou, MS (corresponding author), Shenyang Med Univ, Dept Physiol, Shenyang, Liaoning, Peoples R China.; Zhou, MS (corresponding author), Jinzhou Med Univ, Dept Physiol, Jinzhou, Peoples R China.
EM zhoums1963@163.com
FU National Natural Science Foundation of China [81470532, 81670384,
   31471138]; Liaoning Province; Florida Biomedical Research Grant
FX This work was supported by the grants from the National Natural Science
   Foundation of China (No. 81470532, 81670384), an award for distinguished
   professor in Liaoning Province and a Florida Biomedical Research Grant
   to Ming-Sheng Zhou, by grant from the National Natural Science
   Foundation of China (31471138) to Chang Liu.
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NR 56
TC 27
Z9 28
U1 0
U2 13
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD DEC 13
PY 2017
VL 12
IS 12
AR e0188439
DI 10.1371/journal.pone.0188439
PG 19
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA FP8HS
UT WOS:000417884100017
PM 29236702
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Veronese, N
   Carraro, S
   Bano, G
   Trevisan, C
   Solmi, M
   Luchini, C
   Manzato, E
   Caccialanza, R
   Sergi, G
   Nicetto, D
   Cereda, E
AF Veronese, Nicola
   Carraro, Sara
   Bano, Giulia
   Trevisan, Caterina
   Solmi, Marco
   Luchini, Claudio
   Manzato, Enzo
   Caccialanza, Riccardo
   Sergi, Giuseppe
   Nicetto, Davide
   Cereda, Emanuele
TI Hyperuricemia protects against low bone mineral density, osteoporosis
   and fractures: a systematic review and meta-analysis
SO EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
LA English
DT Review
DE Bone mineral density; fractures; hyperuricemia; osteoporosis; uric acid
ID SERUM URIC-ACID; MENDELIAN RANDOMIZATION; METABOLIC SYNDROME; OXIDATIVE
   STRESS; URATE; ANTIOXIDANTS; ASSOCIATION; WOMEN; RISK; GOUT
AB BackgroundSerum uric acid (SUA) accounts for about 50% of extracellular antioxidant activity, suggesting that hyperuricemia may have a protective role in diseases characterized by high levels of oxidative stress, such as osteoporosis. We aimed to meta-analyse data regarding bone mineral density (BMD), osteoporosis and fractures in people with higher SUA vs. lower SUA concentrations.
   Materials and methodsTwo investigators conducted a literature search using PubMed and Scopus, without language restrictions. Standardized mean differences (SMDs) and 95% confidence intervals (CIs) were used for BMD; risk ratios (RRs) and adjusted odds ratios (ORs) for cross-sectional data. Most possible adjusted hazard ratios (HRs) were used to assess the association between baseline SUA and incident fractures.
   ResultsOf 1405 initial hits, 19 studies were eligible including a total of 55 859 participants. Subjects with higher SUA levels had significantly higher BMD values for the spine (six studies; SMD = 029; 95% CI: 022-035; I-2 = 47%), total hip (seven studies; SMD = 029; 95% CI: 024-034; I-2 = 33%) and femoral neck (six studies; SMD = 025; 95% CI: 016-034; I-2 = 71%). Simple correlation analyses substantially confirmed these findings. An increase of one standard deviation in SUA levels reduced the number of new fractures at follow-up (three studies; HR = 083; 95% CI: 074-092; I-2 = 0%). No significant differences between men and women emerged, although data about women were limited.
   ConclusionsHyperuricemia was found independently associated with BMD and fractures, supporting a protective role for uric acid in bone metabolism disorders.
C1 [Veronese, Nicola; Carraro, Sara; Bano, Giulia; Trevisan, Caterina; Manzato, Enzo; Sergi, Giuseppe] Univ Padua, Geriatr Sect, Dept Med, Via Giustiniani,2, I-35128 Padua, Italy.
   [Veronese, Nicola; Solmi, Marco] Inst Clin Res & Educ Med IREM, Padua, Italy.
   [Solmi, Marco; Luchini, Claudio] Univ Padua, Dept Neurosci, Via Giustiniani 2, I-35128 Padua, Italy.
   [Luchini, Claudio] Verona Univ & Hosp Trust, Dept Pathol & Diagnost, Piazzale Borgo Scuro 1, I-37134 Verona, Italy.
   [Manzato, Enzo] CNR, Aging Branch, Inst Neurosci, Padua, Italy.
   [Caccialanza, Riccardo; Cereda, Emanuele] Fdn IRCCS Policlin San Matteo, Nutr & Dietet Serv, Viale Golgi 19, I-27100 Pavia, Italy.
   [Nicetto, Davide] Azienda Prov Serv Sanitari APSS Treno, Largo Medaglie Doro 9, I-38122 Trento, Italy.
C3 University of Padua; University of Padua; University of Verona; Azienda
   Ospedaliera Universitaria Integrata Verona; Consiglio Nazionale delle
   Ricerche (CNR); IRCCS Fondazione San Matteo
RP Veronese, N (corresponding author), Univ Padua, Dept Med DIMED, Via Giustiniani 2, I-35128 Padua, Italy.
EM ilmannato@gmail.com
RI Trevisan, Caterina/K-2767-2018; SERGI, GIUSEPPE/J-9396-2018; solmi,
   marco/K-3906-2018; Veronese, Nicola/K-4343-2018; Caccialanza,
   Riccardo/J-1904-2015; Luchini, Claudio/Q-4922-2016; Cereda,
   Emanuele/AAA-2247-2019
OI Caccialanza, Riccardo/0000-0002-9379-3569; solmi,
   marco/0000-0003-4877-7233; SERGI, GIUSEPPE/0000-0001-9757-856X; Luchini,
   Claudio/0000-0003-4901-4908; Cereda, Emanuele/0000-0002-0747-1951;
   Trevisan, Caterina/0000-0002-9221-6997
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NR 44
TC 53
Z9 57
U1 1
U2 37
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0014-2972
EI 1365-2362
J9 EUR J CLIN INVEST
JI Eur. J. Clin. Invest.
PD NOV
PY 2016
VL 46
IS 11
BP 920
EP 930
DI 10.1111/eci.12677
PG 11
WC Medicine, General & Internal; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Research & Experimental Medicine
GA EA8WV
UT WOS:000386921500003
PM 27636234
DA 2025-06-11
ER

PT J
AU Handa, P
   Morgan-Stevenson, V
   Maliken, BD
   Nelson, JE
   Washington, S
   Westerman, M
   Yeh, MM
   Kowdley, KV
AF Handa, Priya
   Morgan-Stevenson, Vicki
   Maliken, Bryan D.
   Nelson, James E.
   Washington, Shenna
   Westerman, Mark
   Yeh, Matthew M.
   Kowdley, Kris V.
TI Iron overload results in hepatic oxidative stress, immune cell
   activation, and hepatocellular ballooning injury, leading to
   nonalcoholic steatohepatitis in genetically obese mice
SO AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
LA English
DT Article
DE iron excess; hepatocellular ballooning; inflammasome; immune cell
   activation; reticuloendothelial system
ID FATTY LIVER-DISEASE; HFE MUTATIONS; MODEL; DIET; FIBROSIS; INFLAMMATION;
   MACROPHAGES; HOMEOSTASIS; PROGRESSION; EXPRESSION
AB The aim of this study was to determine the effect of iron overload in the development of nonalcoholic steatohepatitis (NASH) in a genetically obese mouse model (Lepr(db/db)). Leptin receptor-deficient mice were fed a normal or an iron-supplemented chow for 8 wk and switched to normal chow for 8 wk. All dietary iron (DI)-fed mice developed hepatic iron overload predominantly in the reticuloendothelial system. Hepatocellular ballooning injury was observed in the livers of 85% of DI mice, relative to 20% of chow-fed Lepr(db/db). Hepatic malonyldialdehyde levels and mRNA levels of antioxidant genes (Nrf2, Gpx1, and Hmox1) were significantly increased in the DI mice. Hepatic mRNA levels of mitochondrial biogenesis regulators Pgc1 alpha, Tfam, Cox4, and Nrf1 were diminished in the DI mice. In addition, gene expression levels of cytokines (Il6, Tnf alpha) and several innate and adaptive immune cell markers such as Tlr4, Inos, CD11c, CD4, CD8, and Ifn gamma were significantly increased in livers of the DI group. Strikingly, Nlrp3, a component of the inflammasome and Il18, a cytokine elicited by inflammasome activation, were significantly upregulated in the livers of DI mice. In addition, RAW 264.7 macrophages loaded with exogenous iron showed significantly higher levels of inflammatory markers (Inos, Tnf alpha, Mcp1, Tlr4). Thus dietary iron excess leads to hepatic oxidative stress, inflammasome activation, induction of inflammatory and immune mediators, hepatocellular ballooning injury, and therefore NASH in this model. Taken together, these studies indicate a multifactorial role for iron overload in the pathogenesis of NASH in the setting of obesity and metabolic syndrome.
C1 [Handa, Priya; Morgan-Stevenson, Vicki; Kowdley, Kris V.] Swedish Med Ctr, Liver Care Network & Organ Care Res, Seattle, WA USA.
   [Maliken, Bryan D.; Nelson, James E.; Washington, Shenna; Kowdley, Kris V.] Benaroya Res Inst, Seattle, WA USA.
   [Westerman, Mark] Intrins Life Sci, La Jolla, CA USA.
   [Yeh, Matthew M.] Univ Washington, Dept Pathol, Seattle, WA 98195 USA.
C3 Swedish Medical Center; Benaroya Research Institute; University of
   Washington; University of Washington Seattle
RP Kowdley, KV (corresponding author), Swedish Med Ctr, Swedish Liver Care Network & Organ Care Res, 1124 Columbia Ct,Suite 600, Seattle, WA 98104 USA.
EM kris.kowdley@swedish.org
RI Kowdley, Kris/AAF-5202-2019
FU Liver Center of Excellence Research Fund; Benaroya Research Institute,
   Seattle, WA; Virginia Mason Medical Center
FX This work was supported by Liver Center of Excellence Research Fund,
   Virginia Mason Medical Center, and Benaroya Research Institute, Seattle,
   WA.
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NR 34
TC 115
Z9 123
U1 0
U2 35
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0193-1857
EI 1522-1547
J9 AM J PHYSIOL-GASTR L
JI Am. J. Physiol.-Gastroint. Liver Physiol.
PD JAN 15
PY 2016
VL 310
IS 2
BP G117
EP G127
DI 10.1152/ajpgi.00246.2015
PG 11
WC Gastroenterology & Hepatology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Physiology
GA DC2VD
UT WOS:000369074900008
PM 26564716
DA 2025-06-11
ER

PT J
AU Anhê, FF
   Roy, D
   Pilon, G
   Dudonné, S
   Matamoros, S
   Varin, TV
   Garofalo, C
   Moine, Q
   Desjardins, Y
   Levy, E
   Marette, A
AF Anhe, Fernando F.
   Roy, Denis
   Pilon, Genevieve
   Dudonne, Stephanie
   Matamoros, Sebastien
   Varin, Thibault V.
   Garofalo, Carole
   Moine, Quentin
   Desjardins, Yves
   Levy, Emile
   Marette, Andre
TI A polyphenol-rich cranberry extract protects from diet-induced obesity,
   insulin resistance and intestinal inflammation in association with
   increased Akkermansia spp. population in the gut microbiota of
   mice
SO GUT
LA English
DT Article
DE Obesity; Diabetes Mellitus; Prebiotic; Intestinal Permeability;
   Intestinal Bacteria
ID HIGH-FAT-DIET; LIPID-METABOLISM; EXPRESSION; MECHANISM; IMPACT; JUICE;
   PHYTOCHEMICALS; MUCINIPHILA; MARKERS; IMPROVE
AB Objective The increasing prevalence of obesity and type 2 diabetes (T2D) demonstrates the failure of conventional treatments to curb these diseases. The gut microbiota has been put forward as a key player in the pathophysiology of diet-induced T2D. Importantly, cranberry (Vaccinium macrocarpon Aiton) is associated with a number of beneficial health effects. We aimed to investigate the metabolic impact of a cranberry extract (CE) on high fat/high sucrose (HFHS)-fed mice and to determine whether its consequent antidiabetic effects are related to modulations in the gut microbiota.
   Design C57BL/6J mice were fed either a chow or a HFHS diet. HFHS-fed mice were gavaged daily either with vehicle (water) or CE (200mg/kg) for 8weeks. The composition of the gut microbiota was assessed by analysing 16S rRNA gene sequences with 454 pyrosequencing.
   Results CE treatment was found to reduce HFHS-induced weight gain and visceral obesity. CE treatment also decreased liver weight and triglyceride accumulation in association with blunted hepatic oxidative stress and inflammation. CE administration improved insulin sensitivity, as revealed by improved insulin tolerance, lower homeostasis model assessment of insulin resistance and decreased glucose-induced hyperinsulinaemia during an oral glucose tolerance test. CE treatment was found to lower intestinal triglyceride content and to alleviate intestinal inflammation and oxidative stress. Interestingly, CE treatment markedly increased the proportion of the mucin-degrading bacterium Akkermansia in our metagenomic samples.
   Conclusions CE exerts beneficial metabolic effects through improving HFHS diet-induced features of the metabolic syndrome, which is associated with a proportional increase in Akkermansia spp. population.
C1 [Anhe, Fernando F.; Pilon, Genevieve; Marette, Andre] Cardiol Axis Quebec Heart & Lung Inst, Fac Med, Dept Med, Quebec City, PQ, Canada.
   [Anhe, Fernando F.; Roy, Denis; Pilon, Genevieve; Dudonne, Stephanie; Matamoros, Sebastien; Varin, Thibault V.; Desjardins, Yves; Marette, Andre] Univ Laval, Inst Nutr & Funct Foods, Quebec City, PQ, Canada.
   [Garofalo, Carole; Moine, Quentin; Levy, Emile] Hop St Justine, Res Ctr, Montreal, PQ H3T 1C5, Canada.
   [Levy, Emile] Univ Montreal, Fac Med, Dept Nutr, Montreal, PQ H3C 3J7, Canada.
C3 Laval University; Quebec Heart & Lung Institute; Laval University;
   Universite de Montreal; Universite de Montreal
RP Marette, A (corresponding author), Univ Laval, Cardiol Axis Quebec Heart & Lung Inst, Quebec City, PQ G1K 7P4, Canada.
EM andre.marette@criucpq.ulaval.ca
RI Anhê, Fernando/ABD-3859-2020; Marette, Andre/E-9342-2013; Roy,
   Denis/H-4998-2011; Desjardins, Yves/F-1222-2013
OI Forato Anhe, Fernando/0000-0003-1543-4154; Marette,
   Andre/0000-0003-3950-5973; Dudonne, Stephanie/0000-0001-6581-4070; Roy,
   Denis/0000-0002-4229-9245; Desjardins, Yves/0000-0002-0398-2797
FU Ministere du Developpement Economique, de l'Innovation et de
   l'Exportation (MDEIE) [PSR-SIIRI-444]; Agence Universitaire de la
   Francophonie (AUF); Institute of Nutrition and Functional Foods (INAF,
   Laval University)
FX This work was funded by grants from the Ministere du Developpement
   Economique, de l'Innovation et de l'Exportation (MDEIE, PSR-SIIRI-444)
   and Agence Universitaire de la Francophonie (AUF) to AM and by the
   Institute of Nutrition and Functional Foods (INAF, Laval University) to
   YD, AM, DR and EL.
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NR 73
TC 906
Z9 991
U1 32
U2 628
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 0017-5749
EI 1468-3288
J9 GUT
JI Gut
PD JUN
PY 2015
VL 64
IS 6
BP 872
EP 883
DI 10.1136/gutjnl-2014-307142
PG 12
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA CH9TT
UT WOS:000354380000006
PM 25080446
OA Bronze
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Jalal, DI
   Jablonski, KL
   McFann, K
   Chonchol, MB
   Seals, DR
AF Jalal, Diana I.
   Jablonski, Kristen L.
   McFann, Kim
   Chonchol, Michel B.
   Seals, Douglas R.
TI Vascular Endothelial Function Is Not Related to Serum Uric Acid in
   Healthy Adults
SO AMERICAN JOURNAL OF HYPERTENSION
LA English
DT Article
DE blood pressure; endothelium; hypertension; inflammation; uric acid
ID FLOW-MEDIATED DILATION; CHRONIC HEART-FAILURE; OXIDATIVE STRESS;
   NITRIC-OXIDE; CARDIOVASCULAR-DISEASE; HYPERTENSIVE PATIENTS;
   CELL-PROLIFERATION; METABOLIC SYNDROME; BLOOD-PRESSURE; FOLLOW-UP
AB BACKGROUND
   Some experimental evidence suggests that uric acid impairs endothelial function. It is controversial if high uric acid levels and impaired endothelial function are related in healthy adults. In addition, the effect of uric acid on endothelial cells (ECs) of humans is unexplored.
   METHODS
   Data of 107 healthy adult volunteers were analyzed. The association between serum uric acid and endothelial-dependant dilation (EDD) and endothelial-independent dilation (EID) was evaluated by linear regression models. We also examined the relations between uric acid and systemic and cellular markers of inflammation and oxidative stress in all or subsets of participants.
   RESULTS
   Uric acid levels and EDD were not related in unadjusted or adjusted models. There was a significant negative correlation between uric acid and EID in the pooled sample (r = -0.34, P = 0.005). This correlation remained significant after adjusting for demographics (P = 0.04) and was attenuated after adjusting for other cardiac risk factors (P = 0.12). Higher serum uric acid levels were found to correlate significantly with C-reactive protein (CRP) (r = 0.31, P = 0.002). Serum uric acid levels were not associated with brachial artery EC nuclear factor-KB (NF-kappa B) p65 or NADPH oxidase p47(Ph05) expression or with nitrotyrosine staining, but were inversely associated with EC manganese superoxide dismutase (MnSOD) expression (r = -0.5, P = 0.01, n = 25).
   CONCLUSION
   Elevated serum uric acid is not associated with endothelial dysfunction among healthy adults, but is inversely related to EID and EC MnSOD, and positively related to systemic inflammation. These findings may have implications for cardiovascular risk in healthy adults.
C1 [Jalal, Diana I.; McFann, Kim; Chonchol, Michel B.] Univ Colorado, Div Renal Dis & Hypertens, Denver, CO 80202 USA.
   [Jablonski, Kristen L.; Seals, Douglas R.] Univ Colorado, Dept Integrat Physiol, Boulder, CO 80309 USA.
C3 University of Colorado System; University of Colorado Denver; University
   of Colorado System; University of Colorado Boulder
RP Jalal, DI (corresponding author), Univ Colorado, Div Renal Dis & Hypertens, Denver, CO 80202 USA.
EM Diana.Jalal@ucdenver.edu
RI ; Nowak, Kristen/D-4391-2012
OI Jalal, Diana/0000-0002-1975-8650; Nowak, Kristen/0000-0001-9364-3256
FU Veteran's Administration Eastern Colorado Health Care System; 
   [AG013038];  [AG006537];  [RR025780];  [AG033994];  [1K23DK088833-01]; 
   [R01 DK081473-01A1];  [R01DK078112-01A2]
FX This study was funded by the following grants: AG013038, AG006537,
   RR025780, AG033994, 1K23DK088833-01, R01 DK081473-01A1,
   R01DK078112-01A2, as well by the Veteran's Administration Eastern
   Colorado Health Care System. We acknowledge Eric Chung for his help with
   obtaining the immunofluorescence images.
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NR 43
TC 19
Z9 20
U1 0
U2 3
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0895-7061
EI 1941-7225
J9 AM J HYPERTENS
JI Am. J. Hypertens.
PD APR
PY 2012
VL 25
IS 4
BP 407
EP 413
DI 10.1038/ajh.2011.237
PG 7
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 912OX
UT WOS:000301810600004
PM 22237152
OA Green Published
DA 2025-06-11
ER

PT J
AU Newton, BW
   Cologna, SM
   Moya, C
   Russell, DH
   Russell, WK
   Jayaraman, A
AF Newton, Billy W.
   Cologna, Stephanie M.
   Moya, Colby
   Russell, David H.
   Russell, William K.
   Jayaraman, Arul
TI Proteomic Analysis of 3T3-L1 Adipocyte Mitochondria during
   Differentiation and Enlargement
SO JOURNAL OF PROTEOME RESEARCH
LA English
DT Article
DE iTRAQ; quantitative proteomics; adipocyte mitochondrial proteome
ID ISOELECTRIC TRAPPING SEPARATIONS; UNCOUPLING PROTEIN-1 EXPRESSION;
   OXIDATIVE STRESS; ADIPOSE-TISSUE; INSULIN-RESISTANCE; UBIQUINONE
   OXIDOREDUCTASE; SUPEROXIDE-DISMUTASE; METABOLIC SYNDROME; RATS;
   MEMBRANES
AB The increase in adipose tissue mass arises in part from progressive lipid loading and triglyceride accumulation in adipocytes. Enlarged adipocytes produce the highest levels of pro-inflammatory molecules and reactive oxygen species (ROS). Since mitochondria are the site for major metabolic processes (e.g., TCA cycle) that govern the extent of triglyceride accumulation as well as the primary site of ROS generation, we quantitatively investigated changes in the adipocyte mitochondrial proteome during different stages of differentiation and enlargement. Mitochondrial proteins from 3T3-L1 adipocytes at different stages of lipid accumulation (days 0-18) were digested and labeled using the iTRAQ 8-plex kit. The labeled peptides were fractionated using a liquid phase isoelectric fractionation system (MSWIFT) to increase the depth of proteome coverage and analyzed using LC-MS/MS. A total of 631 proteins in the mitochondrial fraction, including endoplasmic reticulum-associated and golgi-related mitochondrial proteins, were identified and classified into 12 functional categories. A total of 123 proteins demonstrated a statistically significant change in expression in at least one of the time points over the course of the experiment. The identified proteins included enzymes and transporters involved in the TCA cycle, fatty acid oxidation, and ATP synthesis. Our results indicate that cultured adipocytes enter a state of metabolic-overdrive where increased flux through the TCA cycle and increased fatty acid oxidation occur simultaneously. The proteomic data also suggest that accumulation of reduced electron carriers and the resultant oxidative stress may be attractive targets for modulating adipocyte function in metabolic disorders.
C1 [Newton, Billy W.; Moya, Colby; Jayaraman, Arul] Texas A&M Univ, Dept Chem Engn, College Stn, TX 77843 USA.
   [Cologna, Stephanie M.; Russell, David H.; Russell, William K.] Texas A&M Univ, Dept Chem, College Stn, TX 77843 USA.
   [Jayaraman, Arul] Texas A&M Univ, Dept Biomed Engn, College Stn, TX 77843 USA.
C3 Texas A&M University System; Texas A&M University College Station; Texas
   A&M University System; Texas A&M University College Station; Texas A&M
   University System; Texas A&M University College Station
RP Jayaraman, A (corresponding author), 222 Jack E Brown Engn Bldg,3122 TAMU, College Stn, TX 77843 USA.
EM arulj@tamu.edu
RI Russell, David/C-3618-2015
FU National Science Foundation [CBET 0651864]; American Heart Association
   [0755112Y]; NIH [1 S10 RR022378-01]; NSF [MRI-CHE 9629966]; American
   Heart Association (AHA) [0755112Y] Funding Source: American Heart
   Association (AHA)
FX This work was supported in part by a National Science Foundation award
   (CBET 0651864) and a Grant-in-Aid award from the American Heart
   Association (Award 0755112Y) to A.J. Mass Spectrometry analyses were
   performed in The Laboratory for Biological Mass Spectrometry-Texas A&M
   University (LBMS-TAMU). Support from the NIH (1 S10 RR022378-01) and NSF
   (MRI-CHE 9629966) to D.H.R is also acknowledged.
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NR 59
TC 47
Z9 51
U1 0
U2 17
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1535-3893
EI 1535-3907
J9 J PROTEOME RES
JI J. Proteome Res.
PD OCT
PY 2011
VL 10
IS 10
BP 4692
EP 4702
DI 10.1021/pr200491h
PG 11
WC Biochemical Research Methods
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 829RT
UT WOS:000295602700028
PM 21815628
DA 2025-06-11
ER

PT J
AU Koizumi, M
   Yada, T
AF Koizumi, Masaru
   Yada, Toshihiko
TI Sub-chronic stimulation of glucocorticoid receptor impairs and
   mineralocorticoid receptor protects cytosolic Ca<SUP>2+</SUP> responses
   to glucose in pancreatic β-cells
SO JOURNAL OF ENDOCRINOLOGY
LA English
DT Article
ID INSULIN-SECRETION; RELEASE; ISLETS; DEXAMETHASONE; INHIBITION; STRESS;
   RATS; ACTIVATION; PREVENTION; GHRELIN
AB The development of diabetes associated with stress, obesity, and metabolic syndrome involves elevated plasma glucocorticoid levels. It has been shown that short-term (< 1 day) exposure to glucocorticoids reduces insulin secretion from pancreatic islets by affecting several steps of glucose signaling in beta-cells. However, longer term direct effects of glucocorticoids on beta-cells remain to be established. In this study, single beta-cells isolated from rat islets were treated with glucocorticoids, mineralocorticoids, and their receptor agonists/antagonists for 3 days in culture, followed by assesment of the beta-cell responsiveness to glucose by measuring cytosolic Ca2+ concentration ([Ca2+](i)) using fura-2. Following treatment with corticosterone at 10-500 ng/ml for 3 days, the first-phase [Ca2+](i) response to 8.3 mM glucose in beta-cells was suppressed. Simultaneous administration of RU-486, a glucocorticoid receptor (GR) antagonist, prevented this suppression. RU-486 by itself promoted the beta-cell [Ca2+](i) response to glucose. Conversely, dexamethasone (1000 ng/ml), a highly selective GR agonist, impaired beta-cell [Ca2+](i) responses to glucose. A nuncralocorticoid receptor (MR) antagonist spironolactone, co-administered with corticosterone, further depressed [Ca2+], responses to glucose, while in MP, ligand aldosterone attenuated the corticosterone inhibition of [Ca2+](i) responses. Neither spironolactone nor aldosterone by itself affected [Ca2+](i) responses. These results indicate that long-term treatment with orticosterone impairs beta-cell [Ca2+](i) responses to glucose. This effect is mediated by GR, and attenuated partially by simultaneous NIP, stimulation by corticosterone. The results show a novel function of MR to protect islet beta-cells against deteriorating glucocorticoid action via GR.
C1 [Koizumi, Masaru; Yada, Toshihiko] Jichi Med Univ Sch Med, Dept Physiol, Div Integrat Physiol, Shimotsuke, Tochigi 3290498, Japan.
   [Koizumi, Masaru] Jichi Med Univ Sch Med, Dept Surg, Shimotsuke, Tochigi 3290498, Japan.
C3 Jichi Medical University; Jichi Medical University
RP Yada, T (corresponding author), Jichi Med Univ Sch Med, Dept Physiol, Div Integrat Physiol, Yakushiji 3311-1, Shimotsuke, Tochigi 3290498, Japan.
EM tyada@jichi.ac.jp
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NR 31
TC 18
Z9 25
U1 0
U2 2
PU SOC ENDOCRINOLOGY
PI BRISTOL
PA 22 APEX COURT, WOODLANDS, BRADLEY STOKE, BRISTOL BS32 4JT, ENGLAND
SN 0022-0795
J9 J ENDOCRINOL
JI J. Endocrinol.
PD MAY
PY 2008
VL 197
IS 2
BP 221
EP 229
DI 10.1677/JOE-07-0462
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 302PL
UT WOS:000255980600004
PM 18434352
OA Bronze
DA 2025-06-11
ER

PT J
AU Meza-Ramos, A
   Alcarraz, A
   Lazo-Rodriguez, M
   Sanguesa, G
   Banon-Maneus, E
   Rovira, J
   Ramirez-Bajo, MJ
   Sitges, M
   Mont, L
   Ventura-Aguiar, P
   Batlle, M
   Guasch, E
AF Meza-Ramos, Aline
   Alcarraz, Anna
   Lazo-Rodriguez, Marta
   Sanguesa, Gemma
   Banon-Maneus, Elisenda
   Rovira, Jordi
   Ramirez-Bajo, Maria Jose
   Sitges, Marta
   Mont, Lluis
   Ventura-Aguiar, Pedro
   Batlle, Montserrat
   Guasch, Eduard
TI High-Intensity Exercise Promotes Deleterious Cardiovascular Remodeling
   in a High-Cardiovascular-Risk Model: A Role for Oxidative Stress
SO ANTIOXIDANTS
LA English
DT Article
DE strenuous exercise; high cardiovascular risk; cardiovascular remodeling;
   kidney disease; metabolic syndrome; animal model
ID CORONARY ATHEROSCLEROSIS; PHYSICAL-ACTIVITY; DISEASE; DYSFUNCTION;
   ASSOCIATION; PREVALENCE; MORTALITY; OBESITY; RAT
AB Although the benefits of moderate exercise in patients at high cardiovascular risk are well established, the effects of strenuous exercise remain unknown. We aimed to study the impact of strenuous exercise in a very high cardiovascular risk model. Nephrectomized aged Zucker obese rats were trained at a moderate (MOD) or high (INT) intensity or were kept sedentary (SED) for 10 weeks. Subsequently, echocardiography and ex vivo vascular reactivity assays were performed, and blood, aortas, perivascular adipose tissue (PVAT), and left ventricles (LVs) were harvested. An improved risk profile consisting of decreased body weight and improved response to a glucose tolerance test was noted in the trained groups. Vascular reactivity experiments in the descending thoracic aorta demonstrated increased endothelial NO release in the MOD group but not in the INT group, compared with SED; the free radical scavenger TEMPOL improved endothelial function in INT rats to a similar level as MOD. An imbalance in the expression of oxidative stress-related genes toward a pro-oxidant environment was observed in the PVAT of INT rats. In the heart, INT training promoted eccentric hypertrophy and a mild reduction in ejection fraction. Obesity was associated with LV fibrosis and a transition toward & beta;-myosin heavy chain and the N2Ba titin isoform. Exercise reverted the myosin imbalance, but only MOD reduced the predominance of the N2Ba titin isoform. In conclusion, moderate exercise yields the most intense cardiovascular benefits in a high-cardiovascular-risk animal model, while intense training partially reverts them.
C1 [Meza-Ramos, Aline; Alcarraz, Anna; Lazo-Rodriguez, Marta; Sanguesa, Gemma; Banon-Maneus, Elisenda; Rovira, Jordi; Ramirez-Bajo, Maria Jose; Sitges, Marta; Mont, Lluis; Ventura-Aguiar, Pedro; Batlle, Montserrat; Guasch, Eduard] Inst Invest Biomed August Pi i Sunyer IDIBAPS, Barcelona 08036, Spain.
   [Meza-Ramos, Aline; Alcarraz, Anna; Sitges, Marta; Mont, Lluis; Guasch, Eduard] Univ Barcelona, Med Dept, Barcelona 08036, Spain.
   [Meza-Ramos, Aline] Consejo Nacl Ciencia & Tecnol CONACyT, Ciudad De Mexico 03940, Mexico.
   [Lazo-Rodriguez, Marta; Banon-Maneus, Elisenda; Rovira, Jordi; Ramirez-Bajo, Maria Jose; Ventura-Aguiar, Pedro] Lab Expt Nefrol & Trasplantament LENIT, Barcelona 08036, Spain.
   [Sitges, Marta; Mont, Lluis; Guasch, Eduard] Clin Barcelona, Cardiovasc Inst, Barcelona 08036, Spain.
   [Sitges, Marta; Mont, Lluis; Batlle, Montserrat; Guasch, Eduard] Ctr Invest Biomed Red Enfermedades Cardiovasc CIBE, Madrid 28029, Spain.
   [Ventura-Aguiar, Pedro] Clin Barcelona, Dept Nephrol & Kidney Transplantat, Barcelona 08036, Spain.
   [Sanguesa, Gemma] Univ Vic, Univ Cent Catalunya UVic UCC, Fac Ciencies Salut Manresa, Manresa 08242, Spain.
   [Sanguesa, Gemma] Inst Recerca & Innovacioen Ciencies Vida & Salut C, Grup Recerca Reparacio & Regeneracio Tissular TR2L, Vic 08500, Spain.
C3 University of Barcelona; Hospital Clinic de Barcelona; IDIBAPS;
   University of Barcelona; Consejo Nacional de Ciencia y Tecnologia
   (CONACyT); CIBER - Centro de Investigacion Biomedica en Red; CIBERCV;
   Universitat de Vic - Universitat Central de Catalunya (UVic-UCC)
RP Batlle, M; Guasch, E (corresponding author), Inst Invest Biomed August Pi i Sunyer IDIBAPS, Barcelona 08036, Spain.; Guasch, E (corresponding author), Univ Barcelona, Med Dept, Barcelona 08036, Spain.; Guasch, E (corresponding author), Clin Barcelona, Cardiovasc Inst, Barcelona 08036, Spain.; Batlle, M; Guasch, E (corresponding author), Ctr Invest Biomed Red Enfermedades Cardiovasc CIBE, Madrid 28029, Spain.
EM cmeza@recerca.clinic.cat; aalcarraz@recerca.clinic.cat;
   mlazo@recerca.clinic.cat; gsanguesa@umanresa.cat;
   ebanon@recerca.clinic.cat; jrovira1@recerca.clinic.cat;
   mramire1@recerca.clinic.cat; msitges@clinic.cat; lmont@clinic.cat;
   pventura@clinic.cat; mbatlle@recerca.clinic.cat; eguasch@clinic.cat
RI Ventura-Aguiar, Pedro/S-9481-2019; Ramirez Bajo, Maria
   Jose/HSG-3777-2023; Rovira, Jordi/A-9603-2017; Guasch,
   Eduard/D-1243-2013; Batlle, Montserrat/N-3168-2014
OI MEZA RAMOS, ALINE CECILIA/0000-0002-1393-9258; Rovira,
   Jordi/0000-0001-8737-5005; Sanguesa, Gemma/0000-0002-6902-4372;
   ramirez-bajo, maria jose/0000-0003-0119-1331; Guasch,
   Eduard/0000-0003-4238-5319; Batlle, Montserrat/0000-0002-3034-2023;
   Alcarraz Garcia, Anna/0000-0002-5807-1544
FU Instituto de Salud Carlos III [PI19/00443, PI22/00953]; CERCA
   program/Generalitat de Catalunya; CIBERCV [16/11/00354]; Consejo
   Superior de Deportes [EXP_75119]; European Regional Development Fund
   (FEDER)
FX This work was partially supported by grants from the Instituto de Salud
   Carlos III (PI19/00443; PI22/00953); the CERCA program/Generalitat de
   Catalunya; the CIBERCV (16/11/00354); Consejo Superior de Deportes
   (EXP_75119); and the European Regional Development Fund (FEDER).
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NR 43
TC 2
Z9 2
U1 2
U2 18
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD JUL
PY 2023
VL 12
IS 7
AR 1462
DI 10.3390/antiox12071462
PG 22
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA N6EQ2
UT WOS:001037925100001
PM 37508000
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Ibeh, S
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   Ahmad, F
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   Mechref, Y
   El-Yazbi, AF
   Kobeissy, F
AF Ibeh, Stanley
   Bakkar, Nour-Mounira Z.
   Ahmad, Fatima
   Nwaiwu, Judith
   Barsa, Chloe
   Mekhjian, Sarine
   Reslan, Mohammad Amine
   Eid, Ali H.
   Harati, Hayat
   Nabha, Sanaa
   Mechref, Yehia
   El-Yazbi, Ahmed F.
   Kobeissy, Firas
TI High fat diet exacerbates long-term metabolic, neuropathological, and
   behavioral derangements in an experimental mouse model of traumatic
   brain injury
SO LIFE SCIENCES
LA English
DT Article
DE Traumatic brain injury; High-fat diet; Metabolic syndrome;
   Neuroinflammation; Neurodegeneration; Oxidative stress
ID CELL-DEATH; IMPAIRMENT; AUTOPHAGY; PROLIFERATION; CONSEQUENCES;
   MECHANISMS; PREVENTION; PLASTICITY; DEFICITS; MICE
AB Aims: Traumatic brain injury (TBI) constitutes a serious public health concern. Although TBI targets the brain, it can exert several systemic effects which can worsen the complications observed in TBI subjects. Currently, there is no FDA-approved therapy available for its treatment. Thus, there has been an increasing need to understand other factors that could modulate TBI outcomes. Among the factors involved are diet and lifestyle. High-fat diets (HFD), rich in saturated fat, have been associated with adverse effects on brain health.Main methods: To study this phenomenon, an experimental mouse model of open head injury, induced by the controlled cortical impact was used along with high-fat feeding to evaluate the impact of HFD on brain injury outcomes. Mice were fed HFD for a period of two months where several neurological, behavioral, and molecular outcomes were assessed to investigate the impact on chronic consequences of the injury 30 days post-TBI.Key findings: Two months of HFD feeding, together with TBI, led to a notable metabolic, neurological, and behavioral impairment. HFD was associated with increased blood glucose and fat-to-lean ratio. Spatial learning and memory, as well as motor coordination, were all significantly impaired. Notably, HFD aggravated neuro-inflammation, oxidative stress, and neurodegeneration. Also, cell proliferation post-TBI was repressed by HFD, which was accompanied by an increased lesion volume.Significance: Our research indicated that chronic HFD feeding can worsen functional outcomes, predispose to neurodegeneration, and decrease brain recovery post-TBI. This sheds light on the clinical impact of HFD on TBI pathophysiology and rehabilitation as well.
C1 [Ibeh, Stanley; Ahmad, Fatima; Nwaiwu, Judith; Barsa, Chloe; Mekhjian, Sarine; Reslan, Mohammad Amine; Kobeissy, Firas] Amer Univ Beirut, Fac Med, Dept Biochem & Mol Genet, Beirut, Lebanon.
   [Bakkar, Nour-Mounira Z.; El-Yazbi, Ahmed F.] Amer Univ Beirut, Fac Med, Dept Pharmacol & Toxicol, Beirut, Lebanon.
   [Ahmad, Fatima; Harati, Hayat; Nabha, Sanaa] Lebanese Univ, Neurosci Res Ctr, Beirut, Lebanon.
   [Eid, Ali H.] Qatar Univ, Coll Med, Dept Basic Med Sci, QU Hlth, Doha, Qatar.
   [Nwaiwu, Judith; Mechref, Yehia] Texas Tech Univ, Dept Chem, Lubbock, TX USA.
   [El-Yazbi, Ahmed F.] Alexandria Univ, Fac Pharm, Dept Pharmacol & Toxicol, Alexandria, Egypt.
   [El-Yazbi, Ahmed F.] Alamein Int Univ, Fac Pharm, Al Alamein, Egypt.
   [Kobeissy, Firas] Morehouse Sch Med, Ctr Neurotrauma Multi & Biomarkers CNMB, Dept Neurobiol, 720 Westview Dr SW, Atlanta, GA 30310 USA.
   [El-Yazbi, Ahmed F.] Alamein Int Sch, Fac Pharm, Dept Pharmacol & Toxicol, Al Alamein, Egypt.
   [Kobeissy, Firas] Amer Univ Beirut, Fac Med, Dept Biochem & Mol Genet, POB 11-0236, Beirut 11072020, Lebanon.
C3 American University of Beirut; American University of Beirut; Lebanese
   University; Qatar University; Texas Tech University System; Texas Tech
   University; Egyptian Knowledge Bank (EKB); Alexandria University;
   Alamein International University (AIU); Morehouse School of Medicine;
   American University of Beirut
RP El-Yazbi, AF (corresponding author), Alamein Int Sch, Fac Pharm, Dept Pharmacol & Toxicol, Al Alamein, Egypt.; Kobeissy, F (corresponding author), Amer Univ Beirut, Fac Med, Dept Biochem & Mol Genet, POB 11-0236, Beirut 11072020, Lebanon.
EM ahmed.fawzy.aly@alexu.edu.eg; firasko@gmail.com
RI Eid, Ali/ABD-6291-2021; Nwaiwu, Judith/MSW-6483-2025; Bakkar,
   Nour/MGA-8112-2025; El-Yazbi, Ahmed/AAT-6837-2021; Kobeissy,
   Firas/E-7042-2017
OI Ibeh, Stanley/0000-0001-6389-6906; Bakkar,
   Nour-Mounira/0000-0002-6403-9348
FU Science, Technology and Innovation Funding Authority [45912]; American
   University of Beirut Faculty of Medicine, Medical Practice Plan (AUB-FM
   MPP) [320112]
FX This work was funded by grants from the Science, Technology and
   Innovation Funding Authority to AFE (45912) and American University of
   Beirut Faculty of Medicine, Medical Practice Plan (AUB-FM MPP) to FK
   (320112) . We thank the members of Dr. Ahmed El-Yazbi lab. (Nahed
   Mogharbil & Dr. Rana Alaaeddine) for their sincere help in conducting
   the cardiovascular experiments. We thank Leila Nasrallah and Yara Yehya
   for their help in the neurological experiments. We thank Dr. GerryShaw,
   the CEO of EnCor Biotechnology Inc. Gainesville, Fl, USA for helping us
   with the antibodies.
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NR 93
TC 8
Z9 8
U1 0
U2 7
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0024-3205
EI 1879-0631
J9 LIFE SCI
JI Life Sci.
PD FEB 1
PY 2023
VL 314
AR 121316
DI 10.1016/j.lfs.2022.121316
EA DEC 2022
PG 17
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA 8C2VX
UT WOS:000917473500001
PM 36565814
OA Green Published
DA 2025-06-11
ER

PT J
AU Boozari, M
   Hosseinzadeh, H
AF Boozari, Motahareh
   Hosseinzadeh, Hossein
TI Crocin molecular signaling pathways at a glance: A comprehensive review
SO PHYTOTHERAPY RESEARCH
LA English
DT Review
DE biological effects; Crocin; Crocus sativus; saffron; signaling pathways
ID RETINAL GANGLION-CELLS; SATIVUS L.; OXIDATIVE STRESS; AQUEOUS EXTRACT;
   BREAST-CANCER; ALZHEIMERS-DISEASE; METABOLIC SYNDROME; CATENIN PATHWAY;
   GDNF EXPRESSION; SAFFRON
AB Crocin is a hydrophilic carotenoid that is synthesized in the flowers of the Crocus genus. Numerous in vitro and in vivo research projects have been published about the biological and pharmacological properties and toxicity of crocin. Crocin acts as a memory enhancer, anxiolytic, aphrodisiac, antidepressant, neuroprotective, and so on. Here, we introduce an updated and comprehensive review of crocin molecular mechanisms based on previously examined and mentioned in the literature. Different studies confirmed the significant effect of crocin to control pathological conditions, including oxidative stress, inflammation, metabolic disorders, neurodegenerative disorders, and cancer. The neuroprotective effect of crocin could be related to the activation of phosphatidylinositol 3-kinase/protein kinase B (PI3K/AKT)/mammalian target of rapamycin (mTOR), Notch, and cyclic-AMP response element-binding protein signaling pathways. The crocin also protects the cardiovascular system through the inhibitory effect on toll-like receptors. The regulatory effect of crocin on PI3K/AKT/mTOR, AMP-activated protein kinase, mitogen-activated protein kinases (MAPK), and peroxisome proliferator-activated receptor pathways can play an effective role in the treatment of metabolic disorders. The crocin has anticancer activity through the PI3K/AKT/mTOR, MAPK, vascular endothelial growth factor, Wnt/beta-catenin, and Janus kinases-signal transducer and activator of transcription suppression. Also, the nuclear factor-erythroid factor 2-related factor 2 and p53 signaling pathway activation may be effective in the anticancer effect of crocin. Finally, among signaling pathways regulated by crocin, the most important ones seem to be those related to the regulatory effect on the PI3K/AKT/mTOR pathway.
C1 [Boozari, Motahareh] Mashhad Univ Med Sci, Sch Pharm, Dept Pharmacognosy, Mashhad, Razavi Khorasan, Iran.
   [Hosseinzadeh, Hossein] Mashhad Univ Med Sci, Sch Pharm, Dept Pharmacodynam & Toxicol, Mashhad, Razavi Khorasan, Iran.
   [Hosseinzadeh, Hossein] Mashhad Univ Med Sci, Pharmaceut Res Ctr, Pharmaceut Technol Inst, Mashhad, Razavi Khorasan, Iran.
C3 Mashhad University of Medical Sciences; Mashhad University of Medical
   Sciences; Mashhad University of Medical Sciences
RP Hosseinzadeh, H (corresponding author), Mashhad Univ Med Sci, Pharmaceut Res Ctr, Pharmaceut Technol Inst, Mashhad, Razavi Khorasan, Iran.
EM hosseinzadehh@mums.ac.ir
RI Boozari, Motahareh/ABE-8523-2020; Hosseinzadeh, Hossein/F-3013-2010
OI Hosseinzadeh, Hossein/0000-0002-3483-851X; Boozari,
   Motahareh/0000-0001-8172-2264
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NR 189
TC 26
Z9 30
U1 2
U2 37
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0951-418X
EI 1099-1573
J9 PHYTOTHER RES
JI Phytother. Res.
PD OCT
PY 2022
VL 36
IS 10
BP 3859
EP 3884
DI 10.1002/ptr.7583
EA AUG 2022
PG 26
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 5E9QF
UT WOS:000843727900001
PM 35989419
DA 2025-06-11
ER

PT J
AU Park, SS
   Perez, JLP
   Gandara, BP
   Agudelo, CW
   Ortega, RR
   Ahmed, H
   Garcia-Arcos, I
   McCarthy, C
   Geraghty, P
AF Park, Sangmi S.
   Perez Perez, Jessica L.
   Perez Gandara, Brais
   Agudelo, Christina W.
   Rodriguez Ortega, Romy
   Ahmed, Huma
   Garcia-Arcos, Itsaso
   McCarthy, Cormac
   Geraghty, Patrick
TI Mechanisms Linking COPD to Type 1 and 2 Diabetes Mellitus: Is There a
   Relationship between Diabetes and COPD?
SO MEDICINA-LITHUANIA
LA English
DT Review
DE chronic obstructive pulmonary disease; diabetes; hyperglycemia;
   inflammation; oxidative stress; insulin; metabolism
ID OBSTRUCTIVE PULMONARY-DISEASE; TOLL-LIKE RECEPTORS; GLUCAGON-LIKE
   PEPTIDE-1; FACTOR-KAPPA-B; OXIDATIVE STRESS; LUNG-FUNCTION; SYSTEMIC
   INFLAMMATION; INSULIN-RESISTANCE; METABOLIC SYNDROME; DIETARY-INTAKE
AB Chronic obstructive pulmonary disease (COPD) patients frequently suffer from multiple comorbidities, resulting in poor outcomes for these patients. Diabetes is observed at a higher frequency in COPD patients than in the general population. Both type 1 and 2 diabetes mellitus are associated with pulmonary complications, and similar therapeutic strategies are proposed to treat these conditions. Epidemiological studies and disease models have increased our knowledge of these clinical associations. Several recent genome-wide association studies have identified positive genetic correlations between lung function and obesity, possibly due to alterations in genes linked to cell proliferation; embryo, skeletal, and tissue development; and regulation of gene expression. These studies suggest that genetic predisposition, in addition to weight gain, can influence lung function. Cigarette smoke exposure can also influence the differential methylation of CpG sites in genes linked to diabetes and COPD, and smoke-related single nucleotide polymorphisms are associated with resting heart rate and coronary artery disease. Despite the vast literature on clinical disease association, little direct mechanistic evidence is currently available demonstrating that either disease influences the progression of the other, but common pharmacological approaches could slow the progression of these diseases. Here, we review the clinical and scientific literature to discuss whether mechanisms beyond preexisting conditions, lifestyle, and weight gain contribute to the development of COPD associated with diabetes. Specifically, we outline environmental and genetic confounders linked with these diseases.
C1 [Park, Sangmi S.; Perez Perez, Jessica L.; Perez Gandara, Brais; Agudelo, Christina W.; Rodriguez Ortega, Romy; Ahmed, Huma; Garcia-Arcos, Itsaso; Geraghty, Patrick] SUNY Downstate Hlth Sci Univ, Dept Med, Brooklyn, NY 11203 USA.
   [McCarthy, Cormac] Univ Coll Dublin, St Vincents Univ Hosp, Educ & Res Ctr, Sch Med, Dublin D04 T6F4, Ireland.
C3 State University of New York (SUNY) System; SUNY Downstate Health
   Sciences University; University College Dublin; Saint Vincent's
   University Hospital
RP Geraghty, P (corresponding author), SUNY Downstate Hlth Sci Univ, Dept Med, Brooklyn, NY 11203 USA.
EM sangmi.park01@downstate.edu; jessica.perezperez@downstate.edu;
   brais.perezgandara@downstate.edu; christina.agudelo@downstate.edu;
   romy.rodriguezortega@downstate.edu; huma.ahmed@downstate.edu;
   itsaso.garcia-arcos@downstate.edu; cormac.mccarthy@ucd.ie;
   patrick.geraghty@downstate.edu
RI McCarthy, Cormac/AAA-3086-2019
OI McCarthy, Cormac/0000-0003-2896-5210; Geraghty,
   Patrick/0000-0003-1647-5505
FU Alpha-1 Foundation [493373, 614218]
FX This work was supported by grants made available to P.G. (the Alpha-1
   Foundation, 493373 and 614218).
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NR 226
TC 31
Z9 31
U1 1
U2 15
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1010-660X
EI 1648-9144
J9 MEDICINA-LITHUANIA
JI Med. Lith.
PD AUG
PY 2022
VL 58
IS 8
AR 1030
DI 10.3390/medicina58081030
PG 23
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 4C8TO
UT WOS:000846718500001
PM 36013497
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Najjar, RS
   Mu, SY
   Feresin, RG
AF Najjar, Rami S.
   Mu, Shengyu
   Feresin, Rafaela G.
TI Blueberry Polyphenols Increase Nitric Oxide and Attenuate Angiotensin
   II-Induced Oxidative Stress and Inflammatory Signaling in Human Aortic
   Endothelial Cells
SO ANTIOXIDANTS
LA English
DT Article
DE NRF2; antioxidant enzymes; redox signaling; reactive oxygen species;
   NADPH oxidases; endothelial dysfunction; hypertension; cardiovascular
ID DOUBLE-BLIND; REACTIVE OXYGEN; BLOOD-PRESSURE; NADPH OXIDASE; STAGE
   1-HYPERTENSION; POSTMENOPAUSAL WOMEN; METABOLIC SYNDROME; VASCULAR
   FUNCTION; HYPERTENSION; NRF2
AB Accumulating evidence indicate that blueberries have anti-hypertensive properties, which may be mainly due to its rich polyphenol content and their high antioxidant capacity. Thus, we aimed to investigate the mechanisms by which blueberry polyphenols exert these effects. Human aortic endothelial cells (HAECs) were incubated with 200 mu g/mL blueberry polyphenol extract (BPE) for 1 h prior to a 12 h treatment with angiotensin (Ang) II, a potent vasoconstrictor. Our results indicate that Ang II increased levels of superoxide anions and decreased NO levels in HAECs. These effects were attenuated by pre-treatment with BPE. Ang II increased the expression of the pro-oxidant enzyme NOX1, which was not attenuated by BPE. Pre-treatment with BPE attenuated the Ang II-induced increase in the phosphorylation of the redox-sensitive MAPK kinases, SAPK/JNK and p38. BPE increased the expression of the redox-transcription factor NRF2 as well as detoxifying and antioxidant enzymes it transcribes including HO-1, NQO1, and SOD1. We also show that BPE attenuates the Ang II-induced phosphorylation of the NF-kappa B p65 subunit. Further, we show that inhibition of NRF2 leads to a decrease in the expression of HO-1 and increased phosphorylation of the NF-kappa B p65 subunit in HAECs treated with BPE and Ang II. These findings indicate that BPE acts through a NRF2-dependent mechanism to reduce oxidative stress and increase NO levels in Ang II-treated HAECs.
C1 [Najjar, Rami S.; Feresin, Rafaela G.] Georgia State Univ, Dept Nutr, Atlanta, GA 30302 USA.
   [Mu, Shengyu] Univ Arkansas Med Sci, Dept Pharmacol & Toxicol, Little Rock, AR 72205 USA.
   [Feresin, Rafaela G.] Univ Arkansas Med Sci, Dept Nutr & Dietet, Little Rock, AR 72205 USA.
C3 University System of Georgia; Georgia State University; University of
   Arkansas System; University of Arkansas Medical Sciences; University of
   Arkansas System; University of Arkansas Medical Sciences
RP Feresin, RG (corresponding author), Georgia State Univ, Dept Nutr, Atlanta, GA 30302 USA.; Feresin, RG (corresponding author), Univ Arkansas Med Sci, Dept Nutr & Dietet, Little Rock, AR 72205 USA.
EM rnajjar1@student.gsu.edu; smu@uams.edu; rferesin@gsu.edu
RI Feresin, Rafaela/J-4350-2017; Najjar, Rami/P-7769-2019
OI Najjar, Rami/0000-0001-5348-3008
FU GSU Lewis Foundation Award; UAMS CHP Seed Grant
FX GSU Lewis Foundation Award and UAMS CHP Seed Grant.
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NR 64
TC 17
Z9 17
U1 1
U2 11
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD APR
PY 2022
VL 11
IS 4
AR 616
DI 10.3390/antiox11040616
PG 16
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA 0S3HS
UT WOS:000786169000001
PM 35453301
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Cheng, S
   Yang, Y
   Zhou, Y
   Xiang, W
   Yao, H
   Ma, L
AF Cheng, Shi
   Yang, Yan
   Zhou, Yong
   Xiang, Wei
   Yao, Hua
   Ma, Ling
TI Influence of different concentrations of uric acid on oxidative stress
   in steatosis hepatocytes
SO EXPERIMENTAL AND THERAPEUTIC MEDICINE
LA English
DT Article
DE glutathione; nonalcoholic fatty liver disease; superoxide dismutase 1;
   antioxidant; malonaldehyde
ID FATTY LIVER-DISEASE; HEPATIC STEATOSIS; NONALCOHOLIC STEATOHEPATITIS;
   LIPID-PEROXIDATION; INSULIN-RESISTANCE; METABOLIC SYNDROME; NADPH
   OXIDASE; INFLAMMATION; ASSOCIATION; MECHANISMS
AB The development of nonalcoholic fatty liver disease (NAFLD) is caused by the steatosis of hepatocytes, which induces oxidative stress (OS). Thus, OS has an important role in the development of NAFLD. In the present study, the L-02 hepatocyte cell line was used to develop a steatosis cell model. The best model was determined using an MTT assay and the triglyceride levels. Model cells were treated with high concentrations of uric acid (UA; 0, 5, 10, 20 and 30 mg/dl) for 24, 48, 72 and 96 h. Indicators of oxidation were then measured, which included total superoxide dismutase (SOD), malonaldehyde (MDA) and reduced glutathione (GSH), and the transcriptional and translational levels of SOD1 and -glutamate-cysteine ligase (-GCLC) were also determined. In addition, the intracellular levels of aspartate aminotransferase and alanine aminotransferase (ALT) were detected. The activity of SOD1 decreased over time and the result was supported by the results of western blotting. The transcriptional levels of SOD1 in model cells was significantly higher than untreated cells at 48 h. With the decreased levels of SOD1 and GSH, MDA increased in a time-dependent manner. The content of GSH decreased with time as well, which was also reflected in the results of western blotting. The transcriptional levels of -GCLC in all UA-treated groups were lower when compared with those observed in the model group. The activity of ALT tended to increase, depending on the duration of treatment. Treatment with 5 and 10 mg/dl UA had an antioxidative effect on the model cells, and 30 mg/dl UA treatment for 48 h increased OS in the cells.
C1 [Cheng, Shi; Xiang, Wei; Ma, Ling] Xinjiang Med Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, 393 Xinyi Rd, Urumqi 830011, Xinjiang, Peoples R China.
   [Yang, Yan] Peoples Hosp Childrens Hosp North Hosp, Dept Child Healthcare, Urumqi 830011, Xinjiang, Peoples R China.
   [Zhou, Yong] Xinjiang Med Univ, Sch Basic Med, Dept Biol, Urumqi 830011, Xinjiang, Peoples R China.
   [Yao, Hua] Xinjiang Med Univ, Dept Hlth Management, Affiliated Hosp 1, Urumqi 830054, Xinjiang, Peoples R China.
C3 Xinjiang Medical University; Xinjiang Medical University; Xinjiang
   Medical University
RP Ma, L (corresponding author), Xinjiang Med Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, 393 Xinyi Rd, Urumqi 830011, Xinjiang, Peoples R China.
EM maling3633@126.com
RI yao, hua/JVN-2535-2024; Cheng, Shi/F-5069-2011
FU First Affiliated Hospital of Xinjiang Medical University; School of
   Public Health of Xinjiang Medical University; Natural Science Foundation
   of the Xinjiang Uygur Autonomous Region, China [2015211C011]
FX This study was supported by First Affiliated Hospital of Xinjiang
   Medical University and School of Public Health of Xinjiang Medical
   University and we thank them for their technical assistance. Research
   partially supported by the Natural Science Foundation of the Xinjiang
   Uygur Autonomous Region, China (no. 2015211C011 to L. Ma), which
   appropriated 70 thousand RMB for funds to carry this research out.
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NR 35
TC 13
Z9 15
U1 1
U2 4
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1792-0981
EI 1792-1015
J9 EXP THER MED
JI Exp. Ther. Med.
PD APR
PY 2018
VL 15
IS 4
BP 3659
EP 3665
DI 10.3892/etm.2018.5855
PG 7
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA GB3GV
UT WOS:000428945200071
PM 29545896
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Sultana, MR
   Bagul, PK
   Katare, PB
   Mohammed, SA
   Padiya, R
   Banerjee, SK
AF Sultana, Md Razia
   Bagul, Pankaj K.
   Katare, Parameshwar B.
   Mohammed, Soheb Anwar
   Padiya, Raju
   Banerjee, Sanjay K.
TI Garlic activates SIRT-3 to prevent cardiac oxidative stress and
   mitochondrial dysfunction in diabetes
SO LIFE SCIENCES
LA English
DT Article
DE SIRT3; MnSOD; Garlic; Acetylation; Mitochondria; Diabetic
   cardiomyopathy; Sirtuins
ID FRUCTOSE-FED RATS; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   COMPLICATIONS; RESVERATROL; DEFICIENCY; MECHANISMS; SIRTUINS; HEART
AB Background: Cardiac complications are major contributor in the mortality of diabetic people. Mitochondria] dysfunctioning is a crucial contributor for the cardiac complications in diabetes, and SIRT-3 remains the major mitochondrial deacetylase. We hypothesized whether garlic has any role on SIRT-3 to prevent mitochondrial dysfunction in diabetic heart
   Methods: Rats with developed hyperglycemia after STZ injection were divided into two groups; diabetic (Dia) and diabetic + garlic (Dia + Garl). Garlic was administered at a dose of 250 mg/kg/day, orally for four weeks. An additional group was maintained to evaluate the effect of raw garlic administration on control rat heart.
   Result: We have observed altered functioning of cardiac mitochondrial enzymes involved in metabolic pathways, and increased levels of cardiac ROS with decreased activity of catalase and SOD in diabetic rats. Cardiac mRNA expression of TFAM, PGC-1 alpha, and CO1 was also altered in diabetes. In addition, reduced levels of electron transport chain complexes that observed in Dia group were normalized with garlic administration. This indicates the presence of increased oxidative stress with mitochondrial dysfunctioning in diabetic heart We have observed reduced activity of SIRT3 and increased acetylation of MnSOD. Silencing SIRT-3 in cells also revealed the same. However, administration of garlic improved the SIRT-3 and MnSOD activity, by deacetylating MnSOD. Increased SOD activity was correlated with reduced levels of ROS in garlic-administered rat hearts.
   Conclusion: Collectively, our results provide an insight into garlic's protection to T1DM heart through activation of SIRT3-MnSOD pathway. (C) 2016 Elsevier Inc. All rights reserved.
C1 [Sultana, Md Razia; Padiya, Raju] Indian Inst Chem Technol, Dept Med Chem & Pharmacol, Hyderabad 500007, Andhra Pradesh, India.
   [Bagul, Pankaj K.; Katare, Parameshwar B.; Mohammed, Soheb Anwar; Banerjee, Sanjay K.] Translat Hlth Sci & Technol Inst, Drug Discovery Res Ctr, Faridabad 122001, Haryana, India.
C3 Council of Scientific & Industrial Research (CSIR) - India; CSIR -
   Indian Institute of Chemical Technology (IICT); Department of
   Biotechnology (DBT) India; Translational Health Science & Technology
   Institute (THSTI)
RP Banerjee, SK (corresponding author), Translat Hlth Sci & Technol Inst, Drug Discovery Res Ctr, Faridabad 122001, Haryana, India.
EM mdsultana@gmail.com; pankajbagul2787@gmail.com; pbkatare@gmail.com;
   sohebmsa@gmail.com; rajpadiya@gmail.com; skbanerjee@thsti.res.in
RI Banaś, Elżbieta/W-4583-2017; Dr. Pankaj K. Bagul, M.S/I-3867-2012;
   Banerjee, Sanjay/F-2677-2019; Mohammed, Soheb Anwar/ABF-1388-2021
OI Razia Sultana, Mohammad/0000-0001-9623-479X; Banerjee, Sanjay
   k/0000-0002-0044-0984; Banerjee, Sanjay/0000-0002-4478-7189; Mohammed,
   Soheb Anwar/0000-0002-1737-8291; , Raju Padiya/0000-0002-9772-9118;
   Banerjee, Sanjay/0000-0002-0008-0480
FU Department of Science and Technology (DST) [SB/SO/AS18/2011]; Council of
   Scientific and Industrial Research (CSIR) network project [BSC0103
   UNDO]; DBT; CSIR; ICMR
FX Financial assistance was provided by grant support (SB/SO/AS18/2011)
   from Department of Science and Technology (DST) and (BSC0103 UNDO) from
   Council of Scientific and Industrial Research (CSIR) network project SKB
   is thankful to DBT for providing Ramalingaswami Fellowship, PKB is
   thankful to CSIR and PBK, SAM are thankful to ICMR for providing Senior
   Research Fellowship (SRF).
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NR 34
TC 53
Z9 55
U1 0
U2 24
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0024-3205
EI 1879-0631
J9 LIFE SCI
JI Life Sci.
PD NOV 1
PY 2016
VL 164
BP 42
EP 51
DI 10.1016/j.lfs.2016.08.030
PG 10
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA EB9RT
UT WOS:000387735500006
PM 27590611
DA 2025-06-11
ER

PT J
AU Di Ciaula, A
   Portincasa, P
AF Di Ciaula, Agostino
   Portincasa, Piero
TI Fat, epigenome and pancreatic diseases. Interplay and common pathways
   from a toxic and obesogenic environment
SO EUROPEAN JOURNAL OF INTERNAL MEDICINE
LA English
DT Review
DE Obesity; Adipose tissue; Environment; Epigenome; Pancreatitis;
   Pancreatic cancer
ID BODY-MASS INDEX; RETICULUM STRESS-RESPONSE; BETA-CELL FUNCTION;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; BISPHENOL-A; LIFE-STYLE;
   OXIDATIVE STRESS; ADIPOSE-TISSUE; AIR-POLLUTION
AB The worldwide obesity epidemic is paralleled by a rise in the incidence of pancreatic disorders ranging from "fatty" pancreas to pancreatitis and cancer. Body fat accumulation and pancreatic dysfunctions have common pathways, mainly acting through insulin resistance and low-grade inflammation, frequently mediated by the epigenome. These mechanisms are affected by lifestyle and by the toxic effects of fat and pollutants. An early origin is common, starting in pediatric age or during the fetal life in response to nutritional factors, endocrine disruptor chemicals (EDCs) or parental exposure to toxics. A "fatty pancreas" is frequent in obese and is able to induce pancreatic damage. The fat is a target of EDCs and of the cytotoxic/mutagenic effects of heavy metals, and is the site of bioaccumulation of lipophilic and persistent pollutants related with insulin resistance and able to promote pancreatic cancer. Increased Body Mass Index (BMI) can act as independent risk factor for a more severe course of acute pancreatitis and obesity is also a well-known risk factor for pancreatic cancer, that is related with BMI, insulin resistance, and duration of exposure to the toxic effects of fat and/or of environmental pollutants. All these mechanisms involve gene-environment interactions through epigenetic factors, and might be manipulated by primary prevention measures. Further studies are needed, pointing to better assess the interplays of modifiable factors on both obesity and pancreatic diseases, and to verify the efficacy of primary prevention strategies involving lifestyle and environmental exposure to toxics. (C) 2014 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.
C1 [Di Ciaula, Agostino] Hosp Bisceglie, Div Internal Med, Bisceglie, Italy.
   [Portincasa, Piero] Univ Bari, Sch Med, Dept Biomed Sci & Human Oncol, Clin Med A Murri, I-70124 Bari, Italy.
C3 Universita degli Studi di Bari Aldo Moro
RP Portincasa, P (corresponding author), Univ Bari, Sch Med, Dept Biomed Sci & Human Oncol, Clin Med A Murri, Piazza Giulio Cesare 11, I-70124 Bari, Italy.
EM piero.portincasa@uniba.it
RI portincasa, piero/J-7245-2018; Di Ciaula, Agostino/M-4300-2017
OI portincasa, piero/0000-0001-5359-1471; Di Ciaula,
   Agostino/0000-0002-5476-7376
FU Italian Agency of Drug (AIFA) [MRAR08P011-2012]
FX This work was supported in part by a research grant MRAR08P011-2012 (to
   P.P.) from Italian Agency of Drug (AIFA).
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NR 211
TC 32
Z9 32
U1 0
U2 21
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0953-6205
EI 1879-0828
J9 EUR J INTERN MED
JI Eur. J. Intern. Med.
PD DEC
PY 2014
VL 25
IS 10
BP 865
EP 873
DI 10.1016/j.ejim.2014.10.012
PG 9
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA AZ9AF
UT WOS:000348502800008
PM 25457435
DA 2025-06-11
ER

PT J
AU Tarry-Adkins, JL
   Ozanne, SE
AF Tarry-Adkins, Jane L.
   Ozanne, Susan E.
TI The impact of early nutrition on the ageing trajectory
SO PROCEEDINGS OF THE NUTRITION SOCIETY
LA English
DT Article; Proceedings Paper
CT Annual Summer Meeting of the Nutrition-Society / Conference on Nutrition
   and Healthy Ageing / Symposium 3 on Nutritional Modulation of the Ageing
   Trajectory
CY JUL 15-18, 2013
CL Newcastle Univ, Newcastle upon Tyne, ENGLAND
SP Nutr Soc
HO Newcastle Univ
DE Oxidative stress; Mechanisms; Cellular ageing; Developmental programming
ID LOW-PROTEIN-DIET; INTRAUTERINE GROWTH-RETARDATION; FOR-GESTATIONAL-AGE;
   JUNK FOOD DIET; IMPAIRED OXIDATIVE-PHOSPHORYLATION; MATERNAL IRON
   RESTRICTION; SINGLE-STRAND BREAKS; CHILDREN BORN SMALL; IN-UTERO
   EXPOSURE; LOW-BIRTH-WEIGHT
AB Epidemiological studies, including those in identical twins, and in individuals in utero during periods of famine have provided robust evidence of strong correlations between low birth-weight and subsequent risk of disease in later life, including type 2 diabetes (T2D), CVD, and metabolic syndrome. These and studies in animal models have suggested that the early environment, especially early nutrition, plays an important role in mediating these associations. The concept of early life programming is therefore widely accepted; however the molecular mechanisms by which early environmental insults can have long-term effects on a cell and consequently the metabolism of an organism in later life, are relatively unclear. So far, these mechanisms include permanent structural changes to the organ caused by suboptimal levels of an important factor during a critical developmental period, changes in gene expression caused by epigenetic modifications (including DNA methylation, histone modification and microRNA) and permanent changes in cellular ageing. Many of the conditions associated with early-life nutrition are also those which have an age-associated aetiology. Recently, a common molecular mechanism in animal models of developmental programming and epidemiological studies has been development of oxidative stress and macromolecule damage, specifically DNA damage and telomere shortening. These are phenotypes common to accelerated cellular ageing. Thus, this review will encompass epidemiological and animal models of developmental programming with specific emphasis on cellular ageing and how these could lead to potential therapeutic interventions and strategies which could combat the burden of common age-associated disease, such as T2D and CVD.
C1 [Tarry-Adkins, Jane L.] Univ Cambridge, Metab Res Labs, Cambridge CB2 OQQ, England.
   Univ Cambridge, Addenbrookes Treatment Ctr, Addenbrookes Hosp, Wellcome Trust MRC Inst Metab Sci,MRC,Metab Dis U, Cambridge CB2 OQQ, England.
C3 University of Cambridge; University of Cambridge; Cambridge University
   Hospitals NHS Foundation Trust; Addenbrooke's Hospital
RP Tarry-Adkins, JL (corresponding author), Univ Cambridge, Metab Res Labs, Level 4,Box 289, Cambridge CB2 OQQ, England.
EM janeadkins@googlemail.com
OI Ozanne, Susan/0000-0001-8753-5144; Tarry-Adkins,
   Jane/0000-0001-9569-6132
FU British Heart Foundation [PG/09/037/27387, FS/09/029/27902] Funding
   Source: Medline; Medical Research Council [G0600717, MC_UU_12012/4,
   MC_UU_12012/5] Funding Source: Medline; MRC [G0600717, MC_UU_12012/4,
   MC_UU_12012/5] Funding Source: UKRI
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NR 160
TC 65
Z9 65
U1 0
U2 24
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0029-6651
EI 1475-2719
J9 P NUTR SOC
JI Proc. Nutr. Soc.
PD MAY
PY 2014
VL 73
IS 2
BP 289
EP 301
DI 10.1017/S002966511300387X
PG 13
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Nutrition & Dietetics
GA AE6LF
UT WOS:000334103400015
PM 24411102
OA Bronze
DA 2025-06-11
ER

PT J
AU Barbhuiya, PA
   Yoshitomi, R
   Pathak, MP
AF Barbhuiya, Pervej Alom
   Yoshitomi, Ren
   Pathak, Manash Pratim
TI Understanding the Link Between Sterol Regulatory Element Binding Protein
   (SREBPs) and Metabolic Dysfunction Associated Steatotic Liver Disease
   (MASLD)
SO CURRENT OBESITY REPORTS
LA English
DT Review
DE SREBP; MASLD; SREBP inhibitors; NAFLD; Obesity
ID ENDOPLASMIC-RETICULUM STRESS; DE-NOVO LIPOGENESIS; INDUCED HEPATIC
   STEATOSIS; LIPID-METABOLISM; GENE-EXPRESSION; INSULIN-RESISTANCE;
   INHIBIT ACTIVATION; PROVISIONAL REPORT; CULTURED-CELLS; SMALL-MOLECULE
AB Purpose of the ReviewThis review aims to summarize the current scientific understanding on the complex interplay between sterol regulatory element-binding proteins (SREBPs) and metabolic dysfunction associated steatotic liver disease (MASLD) by critically examining a few significant molecular pathways. Additionally, the review explores the potential of both natural and synthetic SREBP inhibitors as promising therapeutic candidates for MASLD.Recent FindingsSREBPs are central regulators of lipid homeostasis, with SREBP-1c primarily controlling fatty acid synthesis and SREBP-2 regulating cholesterol metabolism. Dysregulation of SREBP activity, often triggered by excessive caloric intake, insulin resistance, or endoplasmic reticulum (ER) stress, contributes to the development of metabolic syndrome and MASLD. SREBP-1c overexpression leads to increased de novo lipogenesis (DNL), hepatic lipid accumulation, and insulin resistance, while SREBP-2 modulates cholesterol metabolism via miRNA-33 and ABCA1 regulation leading to the pathogenesis of MASLD. The PI3K-Akt-mTORC1 pathway plays a critical role in SREBP activation, linking nutrient availability to lipid synthesis. Synthetic SREBP inhibitors, such as fatostatin and 25-hydroxycholesterol, and natural compounds, including kaempferol and resveratrol, show promise in modulating SREBP activity in vivo.ConclusionWhile targeting SREBP pathways presents a promising avenue for mitigating MASLD, further scientific investigation is imperative to identify and validate potential molecular targets. Although current studies on synthetic and natural SREBP inhibitors demonstrate encouraging results, rigorous pre-clinical and clinical research is warranted to translate these findings into effective MASLD treatments.
C1 [Barbhuiya, Pervej Alom; Pathak, Manash Pratim] Assam down town Univ, Fac Pharmaceut Sci, Gauhati 781026, Assam, India.
   [Barbhuiya, Pervej Alom; Pathak, Manash Pratim] Assam down town Univ, Fac Pharmaceut Sci, Ctr Res Ethnomed, Gauhati 781026, Assam, India.
   [Yoshitomi, Ren] AIST, Natl Inst Adv Ind Sci & Technol, Tokyo, Japan.
C3 Assam Down Town University; Assam Down Town University; National
   Institute of Advanced Industrial Science & Technology (AIST)
RP Pathak, MP (corresponding author), Assam down town Univ, Fac Pharmaceut Sci, Gauhati 781026, Assam, India.; Pathak, MP (corresponding author), Assam down town Univ, Fac Pharmaceut Sci, Ctr Res Ethnomed, Gauhati 781026, Assam, India.
EM manashpharma@rediffmail.com
RI Pathak, Manash/I-3539-2019
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NR 129
TC 0
Z9 0
U1 5
U2 5
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 2162-4968
J9 CURR OBES REP
JI Curr. Obes. Rep.
PD APR 14
PY 2025
VL 14
IS 1
AR 36
DI 10.1007/s13679-025-00626-y
PG 19
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 1JL8A
UT WOS:001466480800001
PM 40227546
DA 2025-06-11
ER

PT J
AU Vural, H
   Armutcu, F
   Akyol, O
   Weiskirchen, R
AF Vural, Huseyin
   Armutcu, Ferah
   Akyol, Omer
   Weiskirchen, Ralf
TI The potential pathophysiological role of altered lipid metabolism and
   electronegative low-density lipoprotein (LDL) in non-alcoholic fatty
   liver disease and cardiovascular diseases
SO CLINICA CHIMICA ACTA
LA English
DT Review
DE NAFLD; Lipotoxicity; Inflammation; Electronegative LDL; L5; Liver-heart
   axis
ID ADIPOSE-TISSUE INFLAMMATION; INSULIN-RESISTANCE; STEATOHEPATITIS;
   MARKERS; LOX-1; DYSLIPIDEMIA; LIPOTOXICITY; STRESS; L5-LDL; NAFLD
AB Non-alcoholic fatty liver disease (NAFLD) is an umbrella term for a range of conditions caused by a build-up of fat in the liver. It is usually seen in people who are overweight or obese. Increasingly common around the world, this disease is the most common chronic liver disease in the United States, affecting about a quarter of the population. Recently, the designation of NAFLD as 'metabolic dysfunction-associated fatty liver disease' (MAFLD) has been a subject of current debate. In this context, 'insulin resistance' is the underlying common and basic pathophysiological mechanism of metabolic dysfunction due to its association with obesity, type 2 diabetes mellitus (T2DM), metabolic syndrome, dyslipidemia and NAFLD. All these pathological conditions are among the metabolic risk factors for cardiovascular diseases, too. Also, due to the bidirectional causality between NAFLD and cardiovascular diseases, a liver-heart axis is suggested. Therefore, various factors such as insulin resistance as well as systemic inflammation, cytokines, oxidative stress, adipokines, hepatokines, genes and intestinal microbiota have been identified as possible pathogenic factors that play a role in the explanation of the complex NAFLD and cardiovascular risk relationship. Recent data and cumulative evidence show that electronegative low-density lipoprotein [LDL (-)/L5] cholesterol is a promising biomarker for complex organ interactions and diseases associated with liver-heart axis. In this mini review, we focus not only on recent data on NAFLD mechanisms, but also on the potential of the lipid mediator LDL (-)/L5 as a diagnostic and therapeutic target for liver-heart line diseases.
C1 [Vural, Huseyin; Weiskirchen, Ralf] RWTH Univ Hosp Aachen, Inst Mol Pathobiochem Expt Gene Therapy & Clin Ch, Aachen, Germany.
   [Armutcu, Ferah] Istanbul Univ, Cerrahpasa Med Fac, Dept Biochem, Istanbul, Turkey.
   [Akyol, Omer] Wake Forest Baptist Hlth, Core Lab, 1 Med Ctr Blvd, Winston Salem, NC 27157 USA.
C3 RWTH Aachen University; RWTH Aachen University Hospital; Istanbul
   University - Cerrahpasa; Istanbul University; Wake Forest University;
   Wake Forest Baptist Medical Center
RP Vural, H (corresponding author), RWTH Univ Hosp Aachen, Inst Mol Pathobiochem Expt Gene Therapy & Clin Ch, Aachen, Germany.
EM hvural@ukaachen.de
RI Weiskirchen, Ralf/O-1734-2018
OI Weiskirchen, Ralf/0000-0003-3888-0931; Vural,
   Huseyin/0000-0001-5591-9100
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NR 59
TC 14
Z9 15
U1 0
U2 16
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0009-8981
EI 1873-3492
J9 CLIN CHIM ACTA
JI Clin. Chim. Acta
PD DEC
PY 2021
VL 523
BP 374
EP 379
DI 10.1016/j.cca.2021.10.018
EA OCT 2021
PG 6
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA WS2MX
UT WOS:000715022500012
PM 34678296
DA 2025-06-11
ER

PT J
AU Qiao, MY
   Chen, CL
   Liang, YQ
   Luo, YX
   Wu, WB
AF Qiao, Mengyuan
   Chen, Chongli
   Liang, Yuqing
   Luo, Yuxi
   Wu, Wenbin
TI The Influence of Serum Uric Acid Level on Alzheimer's Disease: A
   Narrative Review
SO BIOMED RESEARCH INTERNATIONAL
LA English
DT Review
ID IMPAIRED COGNITIVE FUNCTION; OXIDATIVE STRESS MARKERS; CHRONIC
   KIDNEY-DISEASE; RISK-FACTOR; METABOLIC SYNDROME; INCIDENT DEMENTIA;
   ASSOCIATION; BRAIN; PEROXYNITRITE; ANTIOXIDANTS
AB As a powerful antioxidant in the human body, uric acid (UA) has been the subject of increasing research that focused on its influence on Alzheimer's disease (AD) in recent years. The latest literature was gathered to describe the influence of serum uric acid (SUA) level on the onset and progression of AD and to analyze the possibility that SUA is a biomarker of Alzheimer's disease. A large number of existing studies suggested that the SUA level was lower or tended to decrease in patients with AD, and increased SUA level may have a protective effect in AD, which could reduce the risk of onset and slowing the course of the disease. However, some Mendelian randomization analyses suggested that genetically determined uric acid was not associated with AD risk. Existing research results are contradictory due to the high inconsistency of the studies, the selection of subjects, and other factors. UA also showed a strong association with cognitive function, and there appeared to be a gender-selective neuroprotective action. Due to its potent antioxidant properties, the low uric acid level may contribute to oxidative stress to accelerate disease progression. But some preclinical data showed a possibility that in some special cases, UA had a prooxidant properties. The possibility was raised in the discussion of the underlying mechanism that both the low uric acid level and the rapidly progressive course of the disease were the consequence of malnutrition. This paper reviews recent advances in the study of SUA and AD which offers the possibility of new biomarker, new prevention, and treatment strategies for Alzheimer's disease.
C1 [Qiao, Mengyuan; Chen, Chongli; Liang, Yuqing; Luo, Yuxi; Wu, Wenbin] Hosp Chengdu Univ Tradit Chinese Med, Dept Geriatr, Chengdu, Sichuan, Peoples R China.
C3 Chengdu University of Traditional Chinese Medicine
RP Wu, WB (corresponding author), Hosp Chengdu Univ Tradit Chinese Med, Dept Geriatr, Chengdu, Sichuan, Peoples R China.
EM wwb1201@vip.sina.com
OI Luo, Yuxi/0000-0002-5282-2757; Qiao, Mengyuan/0000-0001-9834-4597
FU "Xing-lin Scholars" Project of Chengdu University of Traditional Chinese
   Medicine [QNXZ2018004]; Hundred Talents Program; Science and Technology
   Developmental Foundation from the Hospital of Chengdu University of
   Traditional Chinese Medicine [20-Y02]
FX This work was supported by grants from the "Xing-lin Scholars" Project
   of Chengdu University of Traditional Chinese Medicine (No. QNXZ2018004),
   and "Hundred Talents Program" and Science and Technology Developmental
   Foundation from the Hospital of Chengdu University of Traditional
   Chinese Medicine (grant No. 20-Y02).
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NR 64
TC 18
Z9 19
U1 0
U2 20
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2314-6133
EI 2314-6141
J9 BIOMED RES INT
JI Biomed Res. Int.
PD JUN 3
PY 2021
VL 2021
AR 5525710
DI 10.1155/2021/5525710
PG 8
WC Biotechnology & Applied Microbiology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Research & Experimental Medicine
GA ZB6PU
UT WOS:000756962600002
PM 34124244
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Chekkal, H
   Harrat, NE
   Bensalah, F
   Affane, F
   Louala, S
   Lamri-Senhadji, M
AF Chekkal, Hadjera
   Harrat, Nour el Imane
   Bensalah, Fatima
   Affane, Fouad
   Louala, Sabrine
   Lamri-Senhadji, Myriem
TI The cactus cladode (Opuntia ficus indica) modulates uricemia,
   improves endothelial dysfunction and corrects oxidative damage in rats
   fed a cafeteria diet
SO WORLD JOURNAL OF SCIENCE TECHNOLOGY AND SUSTAINABLE DEVELOPMENT
LA English
DT Article
DE Opuntia ficus indica; By-products; Oxidative stress; Endothelial
   dysfunction; Hyperuricemia; Junk food
ID METABOLIC SYNDROME; SKELETAL-MUSCLE; PRICKLY PEAR; URIC-ACID; STRESS;
   SUPPLEMENTATION; COMPONENTS; OBESITY; ASSAYS; SERUM
AB Purpose The effects of Opuntia ficus indica (OFI) cladodes on uricemia level, endothelial dysfunction and oxidative damage were studied in young rats fed a cafeteria diet (CD). Design/methodology/approach A total of 16 young male Wistar rats (weighing 110 +/- 20 g and four weeks old) were divided into two homogenous groups. The first group received a CD containing 50% of hyperlipidic diet and 50% of junk food mix (processed mix: hyper-fat, hyper-salted and sweetened) (CD group), and the second group (CD + OFI nopalitos) received the same diet supplemented with 50 g of fresh OFI nopalitos (young cladodes) for 30 days. Findings OFI nopalitos regulate the hyperuricemia, improve the endothelial dysfunction by raising the bioavailability of nitric oxide(NO) and reduce prooxidant markers by reducing lipid peroxidation and protein oxidation (p < 0.05) and boosting antioxidant capacity and enhancing the antioxidant enzymes activities (p < 0.05) in blood and aorta tissues of rats early fed with a high-fat diet /junk food. Social implications By-products of OFI have specific functional properties that may be beneficial in metabolic disorders and offer a better alternative with an economic and sustainable development perspective. Originality/value By-products of OFI highlight potential functional properties mainly based on its potent antioxidant capacity. By-products of OFI can be used as a promising nutraceutical resource to prevent various metabolic disorders in relation with cardiovascular diseases or hyperuricemia in subjects consuming junk food and or living in the Western society to reach the objectives of health policy and maintain a sustainable health system development.
C1 [Chekkal, Hadjera; Harrat, Nour el Imane; Bensalah, Fatima; Affane, Fouad; Louala, Sabrine; Lamri-Senhadji, Myriem] Univ Oran1 Ahmed Ben Bella Oran, Fac Sci Nat & Vie, Lab Nutr Clin & Metab LNCM, Biol, Oran, Algeria.
RP Lamri-Senhadji, M (corresponding author), Univ Oran1 Ahmed Ben Bella Oran, Fac Sci Nat & Vie, Lab Nutr Clin & Metab LNCM, Biol, Oran, Algeria.
EM mylamri@hotmail.fr
OI LAMRI-SENHADJI, Myriem/0000-0002-9094-3760
FU Ministry of Higher Education and Scientific Research-Algeria
   [D01N01UN310120150023]
FX This work was funded by the Ministry of Higher Education and Scientific
   Research-Algeria (CNEPRU number D01N01UN310120150023).
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NR 51
TC 2
Z9 2
U1 0
U2 8
PU EMERALD GROUP PUBLISHING LTD
PI BINGLEY
PA HOWARD HOUSE, WAGON LANE, BINGLEY BD16 1WA, W YORKSHIRE, ENGLAND
SN 2042-5953
EI 2042-5945
J9 WORLD J SCI TECHNOL
JI World J. Sci. Technol. Sustain. Dev.
PD OCT 5
PY 2020
VL 17
IS 4
BP 355
EP 365
DI 10.1108/WJSTSD-05-2019-0023
EA NOV 2020
PG 11
WC Green & Sustainable Science & Technology
WE Emerging Sources Citation Index (ESCI)
SC Science & Technology - Other Topics
GA PB7VU
UT WOS:000590909700001
DA 2025-06-11
ER

PT J
AU Dong, XL
   Yu, WX
   Li, CM
   Zhou, LP
   Wong, MS
AF Dong, Xiao-Li
   Yu, Wen-Xuan
   Li, Chun-Mei
   Zhou, Li-Ping
   Wong, Man-Sau
TI Chuanxiong (Rhizome of Ligusticum chuanxiong) Protects
   Ovariectomized Hyperlipidemic Rats from Bone Loss
SO AMERICAN JOURNAL OF CHINESE MEDICINE
LA English
DT Article
DE Rhizome of Ligusticum chuanxiong Hort; Bone Loss; High Fat-Sucrose Diet;
   Dyslipidemia; Lipid Deposition; Oxidative Stress
ID HIGH-SATURATED-FAT; FERULIC ACID; OSTEOGENIC DIFFERENTIATION; METABOLIC
   SYNDROME; SUCROSE DIET; OSTEOPOROSIS; ESTROGEN; EXTRACT; DENSITY;
   DISEASE
AB Oxidative stress (OS) is the common mechanism for age-related diseases. The co-occurrence of osteoporosis (OP) and cardiovascular disease (CVD) in postmenopausal women makes it warranted to find a holistic approach for treatment of multiple diseases or conditions. The rhizome of Ligusticum chuanxiong Hort. (CX), which has high anti-oxidant properties and is widely used for CVD treatment in China, might be the potential candidate. In the present study, CX ethanol extract (CXE) was applied to H2O2 induced MG63 cells to study its effects and mechanisms on osteoblastogenesis against OS. CXE was then administered to six-month-old Sprague Dawley sham or ovariectomized (OVX) rats fed either a low saturated fat-sucrose (LFS) or a high fat-sucrose (HFS) diet for 12 weeks, to confirm its anti-osteoporotic effects. The results demonstrated that CXE directly improved proliferation and differentiation in vitro in an H2O2 -induced osteoblast cell model by attenuating cellular reactive oxygen species levels and inhibiting osteoblast apoptosis via PI3K/Akt signaling pathway. CXE significantly improved bone properties as revealed by the increase in trabecular bone mineral density and decrease in trabecular separation at proximal metaphysis of the tibia (PT) in HFS-fed OVX rats but not in LFS-fed OVX rats. CXE ameliorated dyslipidemia, greatly reduced lipid deposition and malondialdehyde levels, improved activities of superoxide dismutase, catalase and glutathione peroxidase in the livers of HFS-fed OVX rats. In conclusion, CXE could favor osteoblastogenesis against OS. The ability of CXE to reduce bone loss in HFS-fed OVX rats was associated with its abilities to correct dyslipidemia, and reduce lipid deposition and OS levels.
C1 [Dong, Xiao-Li; Wong, Man-Sau] State Key Lab Chinese Med & Mol Pharmacol Incubat, Shenzhen, Peoples R China.
   [Dong, Xiao-Li; Wong, Man-Sau] Key Lab Food Biol Safety Control, Shenzhen, Peoples R China.
   [Dong, Xiao-Li; Yu, Wen-Xuan; Zhou, Li-Ping; Wong, Man-Sau] Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Hong Kong, Peoples R China.
   [Li, Chun-Mei] Guangdong Pharmaceut Univ, Dept Biochem & Mol Biol, Guangzhou, Peoples R China.
C3 Hong Kong Polytechnic University; Guangdong Pharmaceutical University
RP Wong, MS (corresponding author), Hong Kong Polytech Univ, Hung Hom, Kowloon, Dept Appl Biol & Chem Technol, Hong Kong, Peoples R China.
EM man-sau.wong@polyu.edu.hk
RI Yu, wx/KRQ-8572-2024; Wong, Man Sau/F-2059-2015
OI Wong, Man Sau/0000-0002-0729-8618; Zhou, Liping/0000-0002-9941-7812
FU Shenzhen Key Laboratory of Food Biological Safety; State Key Laboratory
   of Chinese Medicine and Molecular Pharmacology (Incubation); Shenzhen
   Basic Research Program [JCYJ20170818111103886]; National Natural Science
   Foundation of China [81601110]
FX We thank the Shenzhen Key Laboratory of Food Biological Safety and the
   State Key Laboratory of Chinese Medicine and Molecular Pharmacology
   (Incubation) for their support. This work was supported by Shenzhen
   Basic Research Program (Grant Number JCYJ20170818111103886), National
   Natural Science Foundation of China (Grant Number 81601110).
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NR 31
TC 20
Z9 22
U1 0
U2 22
PU WORLD SCIENTIFIC PUBL CO PTE LTD
PI SINGAPORE
PA 5 TOH TUCK LINK, SINGAPORE 596224, SINGAPORE
SN 0192-415X
EI 1793-6853
J9 AM J CHINESE MED
JI Am. J. Chin. Med.
PY 2020
VL 48
IS 2
BP 463
EP 485
DI 10.1142/S0192415X2050024X
PG 23
WC Integrative & Complementary Medicine; Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine; General & Internal Medicine
GA LL4UY
UT WOS:000531553500012
PM 32138532
DA 2025-06-11
ER

PT J
AU Tartaglia, GM
   Gagliano, N
   Zarbin, L
   Tolomeo, G
   Sforza, C
AF Tartaglia, Gianluca Martino
   Gagliano, Nicoletta
   Zarbin, Luca
   Tolomeo, Giorgia
   Sforza, Chiarella
TI Antioxidant capacity of human saliva and periodontal screening
   assessment in healthy adults
SO ARCHIVES OF ORAL BIOLOGY
LA English
DT Article
DE Periodontal conditions; Saliva; Oxidative stress; Saliva antioxidant
   levels; Periodontal screening and recordings
ID OXIDATIVE STRESS; GINGIVAL FIBROBLASTS; CIGARETTE-SMOKE; METABOLIC
   SYNDROME; GLOBAL BURDEN; URIC-ACID; DISEASE; PATHOGENESIS; CANCER;
   INFLAMMATION
AB Objective: Saliva plays a pivotal role as an antioxidant system, and saliva antioxidant levels are reduced in patients with periodontal disease. Recently, a biochemical test able to determine saliva antioxidant levels was proposed as predictive for oral cavity diseases, but it was not clinically tested. In this preliminary study, we evaluated the relationships between Periodontal Screening and Recordings characteristics of patients and saliva antioxidant levels measures.
   Design: Thirty-nine patients (12 men, 27 women; mean age, 46 years, SD 17) attending the dental hygiene unit of a Private Clinic underwent a Periodontal Screening and Recordings examination and a saliva antioxidant levels measurement using a biochemical commercial test. The results of the clinical periodontal examination were compared to those obtained by the saliva test.
   Results: Approximately 70% of patients showed a low saliva antioxidant levels value, while the other patients had Optimal/Normal values. Thirteen patients (33%) resulted positive to Periodontal Screening and Recordings test. Using Periodontal Screening and Recordings values as gold standard, the saliva antioxidant levels test correctly classified 52.6% of patients; sensitivity was 84.6%, specificity was 36%.
   Conclusions: The saliva antioxidant levels test had a good sensitivity when compared to the gold standard; this finding corroborates the hypothesis that alterations of the oral antioxidant levels are related to periodontal disease. The reduced specificity shows that saliva antioxidant levels test could detect alterations predisposing to periodontal disease before clinically evident aspects. (C) 2017 Elsevier Ltd. All rights reserved.
C1 [Tartaglia, Gianluca Martino; Sforza, Chiarella] Univ Milan, Fac Med & Chirurg, Dipartimento Sci Biomed Salute, FARC,Lab Anat Funz Apparato Stomatognat, Via Luigi Mangiagalli 31, I-20133 Milan, Italy.
   [Gagliano, Nicoletta] Univ Milan, Fac Med & Chirurg, Dipartimento Sci Biomed Salute, Via Luigi Mangiagalli 31, I-20133 Milan, Italy.
   [Tartaglia, Gianluca Martino; Zarbin, Luca; Tolomeo, Giorgia] SST Dent Clin, Via Martin Liberta 58, I-20090 Segrate, MI, Italy.
C3 University of Milan; University of Milan
RP Sforza, C (corresponding author), Dip Sci Biomed Salute, Via Mangiagalli 31, I-20133 Milan, Italy.
EM chiarella.sforza@unimi.it
RI Sforza, Chiarella/C-3008-2015
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NR 40
TC 18
Z9 18
U1 0
U2 12
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0003-9969
EI 1879-1506
J9 ARCH ORAL BIOL
JI Arch. Oral Biol.
PD JUN
PY 2017
VL 78
BP 34
EP 38
DI 10.1016/j.archoralbio.2017.02.003
PG 5
WC Dentistry, Oral Surgery & Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dentistry, Oral Surgery & Medicine
GA EU0RM
UT WOS:000400719000006
PM 28189883
DA 2025-06-11
ER

PT J
AU Rangel-Zúñiga, OA
   Corina, A
   Lucena-Porras, B
   Cruz-Teno, C
   Gómez-Delgado, F
   Jiménez-Lucena, R
   Alcalá-Díaz, JF
   Haro-Mariscal, C
   Yubero-Serrano, EM
   Delgado-Lista, J
   López-Moreno, J
   Rodríguez-Cantalejo, F
   Camargo, A
   Tinahones, FJ
   Ordovás, JM
   López-Miranda, J
   Pérez-Martínez, P
AF Oriol, Alberto Rangel-Zuniga
   Corina, Andreea
   Lucena-Porras, Beatriz
   Cruz-Teno, Cristina
   Gomez-Delgado, Francisco
   Jimenez-Lucena, Rosa
   Francisco Alcala-Diaz, Juan
   Haro-Mariscal, Carmen
   Maria Yubero-Serrano, Elena
   Delgado-Lista, Javier
   Lopez-Moreno, Javier
   Rodriguez-Cantalejo, Fernando
   Camargo, Antonio
   Jose Tinahones, Francisco
   Maria Ordovas, Jose
   Lopez-Miranda, Jose
   Perez-Martinez, Pablo
TI TNFA gene variants related to the inflammatory status and its
   association with cellular aging: From the CORDIOPREV study
SO EXPERIMENTAL GERONTOLOGY
LA English
DT Article
DE TNFA genetic variants; Inflammation; Oxidative stress; Cellular aging;
   Telomere length; CORDIOPREV study
ID HUMAN-DIPLOID FIBROBLASTS; AGE-RELATED DISEASES; OXIDATIVE STRESS;
   CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; DNA-DAMAGE; ALPHA-GENE;
   INSULIN-RESISTANCE; STRAND BREAKS; SENESCENCE
AB Background: Several single nucleotide polymorphisms have been proposed as potential predictors of the development of age-related diseases.
   Objective: To explore whether Tumor Necrosis Factor Alpha (TNFA) gene variants were associated with inflammatory status, thus facilitating the rate of telomere shortening and its relation to cellular aging in a population with established cardiovascular disease from the CORDIOPREV study (NCT00924937).
   Materials and methods: SNPs (rs1800629 and rs1799964) located at the TNFA gene were genotyped by OpenArray platform in 840 subjects with established cardiovascular disease. Relative telomere length was determined by real time PCR and plasma levels of C-reactive protein by ELISA. In a subgroup of 90 subjects, the gene expression profiles of TNFA, IKK beta, p47phox, p40phox, p22phox and gp91phox were determined by qRT-PCR.
   Results: GG subjects for the SNP rs1800629 at the TNFA gene showed shorter relative telomere length and higher plasma levels of hs-CRP than A-allele subjects (p < 0.05). Consistent with these findings, the expression of proinflammatory (TNFA) and pro-oxidant (p47phox and the gp91phox) genes was higher in GG subjects than A allele subjects (p < 0.05).
   Conclusion: Subjects carrying the GG genotype for the SNP rs1800629 at the TNFA gene show a greater activation of the proinflammatory status than A-allele carriers, which is related to ROS formation. These ROS could induce DNA damage especially in the telomeric sequence, by decreasing the telomere length and inducing cellular aging. This effect may also increase the risk of the development of age-related diseases. (C) 2016 Elsevier Inc. All rights reserved.
C1 [Oriol, Alberto Rangel-Zuniga; Corina, Andreea; Lucena-Porras, Beatriz; Cruz-Teno, Cristina; Gomez-Delgado, Francisco; Jimenez-Lucena, Rosa; Francisco Alcala-Diaz, Juan; Haro-Mariscal, Carmen; Maria Yubero-Serrano, Elena; Delgado-Lista, Javier; Lopez-Moreno, Javier; Camargo, Antonio; Lopez-Miranda, Jose; Perez-Martinez, Pablo] Univ Cordoba, Reina Sofia Univ Hosp, IMIBIC, Lipids & Atherosclerosis Unit, Cordoba, Spain.
   [Oriol, Alberto Rangel-Zuniga; Corina, Andreea; Lucena-Porras, Beatriz; Cruz-Teno, Cristina; Gomez-Delgado, Francisco; Jimenez-Lucena, Rosa; Francisco Alcala-Diaz, Juan; Haro-Mariscal, Carmen; Maria Yubero-Serrano, Elena; Delgado-Lista, Javier; Lopez-Moreno, Javier; Camargo, Antonio; Jose Tinahones, Francisco; Lopez-Miranda, Jose; Perez-Martinez, Pablo] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr CIBEROBN, Madrid, Spain.
   [Rodriguez-Cantalejo, Fernando] Reina Sofia Univ Hosp, Biochem Lab, Cordoba, Spain.
   [Maria Ordovas, Jose] Tufts Univ, Nutr & Genom Lab, USDA, Human Nutr Res Ctr Aging, Boston, MA 02111 USA.
   [Maria Ordovas, Jose] IMDEA Food, Madrid, Spain.
   [Maria Ordovas, Jose] CNIC, Madrid, Spain.
   [Jose Tinahones, Francisco] Hosp Virgen de la Victoria, Dept Endocrinol, Biomed Res Lab, Malaga, Spain.
C3 Universidad de Cordoba; CIBER - Centro de Investigacion Biomedica en
   Red; CIBEROBN; Instituto de Salud Carlos III; Hospital Universitario
   Reina Sofia - Cordoba; United States Department of Agriculture (USDA);
   Tufts University; IMDEA Food Institute; Centro Nacional de
   Investigaciones Cardiovasculares (CNIC)
RP Pérez-Martínez, P (corresponding author), Univ Cordoba, Reina Sofia Univ Hosp, IMIBIC, Ave Menendez Pidal S-N, E-14004 Cordoba, Spain.
EM pablopermar@yahoo.es
RI Yubero-Serrano, Elena/H-4832-2013; Tinahones, Francisco/AAB-2882-2020;
   Lopez-Miranda, Jose/Y-8306-2019; Alcala-Diaz, Juan/Q-4455-2019;
   Delgado-Lista, Javier/KAM-7412-2024; Perez Martinez,
   Pablo/AEL-6176-2022; HARO, CARMEN/P-3104-2016; Camargo Garcia,
   Antonio/G-9720-2015; Gomez Delgado, Francisco/H-4552-2015
OI Yubero-Serrano, Elena M/0000-0002-2733-5359; Alcala-Diaz, Juan
   Francisco/0000-0002-4572-3611; Perez Martinez,
   Pablo/0000-0001-7716-8117; HARO, CARMEN/0000-0002-1355-8359; Camargo
   Garcia, Antonio/0000-0002-0415-4184; Delgado Lista, Francisco
   Javier/0000-0002-2982-2716; Lopez-Miranda, Jose/0000-0002-8844-0718;
   Gomez Delgado, Francisco/0000-0002-0216-2084; Rangel-Zuniga, Oriol
   Alberto/0000-0003-3495-5705; Tinahones, Francisco J/0000-0001-6871-4403;
   Jimenez-Lucena, Rosa/0000-0001-7115-3117
FU Fundacion Patrimonio Comunal Olivarero; Junta de Andalucia (Consejeria
   de Salud); Diputaciones de Jaen y Cordoba; Centro de Excelencia en
   Investigacion sobre Aceite de Oliva y Salud; Ministerio de Medio
   Ambiente, Medio Rural y Marino, Gobierno de Espana; Ministerio de
   Economia y Competitividad [FIS PI13/00185, AGL2012/39615]; Proyecto de
   Excelencia, Consejeria de Economia, Innovacion, Ciencia y Empleo
   [CVI-7450]; Research Grant from the European Community (NUTRITECH
   European Integrated Project) [289511]; Fondo Europeo de Desarrollo
   Regional (FEDER); ISCIII [CP14/00114]; Junta de Andalucia (Consejeria de
   Agricultura y Pesca); Junta de Andalucia (Consejeria de Innovacion,
   Ciencia y Empresa)
FX We would like to thank the EASP (Escuela Andaluza de Salud Publica),
   Granada, Spain, which performed the randomization process for this
   study. The CORIOPREV study is supported by the Fundacion Patrimonio
   Comunal Olivarero, Junta de Andalucia (Consejeria de Salud, Consejeria
   de Agricultura y Pesca, Consejeria de Innovacion, Ciencia y Empresa),
   Diputaciones de Jaen y Cordoba, Centro de Excelencia en Investigacion
   sobre Aceite de Oliva y Salud and Ministerio de Medio Ambiente, Medio
   Rural y Marino, Gobierno de Espana. It was partly supported by research
   grants from the Ministerio de Economia y Competitividad (FIS PI13/00185
   to PP-M and AGL2012/39615 to JL-M), Proyecto de Excelencia, Consejeria
   de Economia, Innovacion, Ciencia y Empleo (CVI-7450 to JLM); Research
   Grant from the European Community (NUTRITECH European Integrated
   Project-289511) and Fondo Europeo de Desarrollo Regional (FEDER). A.
   Camargo is supported by an ISCIII research contract (Programa
   Miguel-Servet CP14/00114) and F. Gomez-Delgado is supported by an ISCIII
   research contract (Programa Rio-Hortega). The CIBEROBN is an initiative
   of the Instituto de Salud Carlos III, Madrid, Spain.
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NR 56
TC 12
Z9 12
U1 0
U2 24
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0531-5565
EI 1873-6815
J9 EXP GERONTOL
JI Exp. Gerontol.
PD OCT
PY 2016
VL 83
BP 56
EP 62
DI 10.1016/j.exger.2016.07.015
PG 7
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA DU4XG
UT WOS:000382215600008
PM 27477483
DA 2025-06-11
ER

PT J
AU Kobayashi, N
   Ohno, T
   Yoshida, K
   Fukushima, H
   Mamada, Y
   Nomura, M
   Hirata, H
   Machida, Y
   Shinoda, M
   Suzi, N
   Matsuoka, H
AF Kobayashi, Naohiko
   Ohno, Tomoyuki
   Yoshida, Kohtaro
   Fukushima, Hirornichi
   Mamada, Yasuko
   Nomura, Mika
   Hirata, Hisato
   Machida, Yoshifumi
   Shinoda, Motoo
   Suzi, Noriko
   Matsuoka, Hiroaki
TI Cardioprotective mechanism of telmisartan via PPAR-γ-eNOS pathway in
   Dahl salt-sensitive hypertensive rats
SO AMERICAN JOURNAL OF HYPERTENSION
LA English
DT Article
ID NITRIC-OXIDE PRODUCTION; ANGIOTENSIN-II; ENDOTHELIAL DYSFUNCTION;
   CARDIAC-PERFORMANCE; METABOLIC SYNDROME; RECEPTOR BLOCKERS;
   TROGLITAZONE; EPLERENONE; LIGANDS
AB BACKGROUND
   Recently, some investigators have shown that telmisartan, an angiotensin II (Ang II)-receptor blocker (ARB), is a partial agonist of the peroxisome proliferator-activated receptor-gamma (PPAR-y). We investigate whether telmisartan improves cardiovascular remodeling associated with the production of endothelial nitric oxide synthase (eNCS) through PPAR-gamma, inhibits the Rho-kinase pathway, and suppresses oxidative stress in Dahl salt-sensitive (DS) hypertensive rats.
   METHODS
   Telmisartan (1 mg/kg per day) or telmisartan plus PPAR-gamma inhibitor, GW9662(1 mg/kg per day) was administered from the age of 6-11 weeks. Age-matched male Dahl salt-resistant (DR) rats served as a control group.
   RESULTS
   The levels of eNCS and PPAR-gamma expression, and eNOS phosphorylation were significantly lower in DS rats than in DR rats. the Chronic telmisartan treatment in DS rats significantly increased these parameters, but not telmisartan plus GW9662. Telmisartan effectively inhibited the vascular lesion formation such as medial thickness and perivascular fibrosis, but not telmisartan plus GW9662. Moreover, upregulated RhoA protein, Rho-kinase mRNA, and myosin light-chain phosphorylation in DS rats was decreased by telmisartan to a similar degree as observed after treatment with Y-27632, a selective Rho-kinase inhibitor. In addition, NAD(P)H oxidase p22phox, p47phox, gp91 phox expression, and mitogen-activated protein kinase and its downstream effector p70 S6 kinase phosphorylation in DS rats was also inhibited by telmisartan.
   CONCLUSIONS
   These results suggest that the cardioprotective mechanism of telmisartan may be partly due to improvement of endothelial function associated with PPAR-gamma-eNOS, oxidative stress, and Rho-kinase pathway.
C1 [Kobayashi, Naohiko; Ohno, Tomoyuki; Yoshida, Kohtaro; Fukushima, Hirornichi; Mamada, Yasuko; Nomura, Mika; Matsuoka, Hiroaki] Dokkyo Med Univ, Sch Med, Dept Hypertens & Cardiorenal Med, Mibu, Tochigi, Japan.
   [Hirata, Hisato; Machida, Yoshifumi; Shinoda, Motoo] Dokkyo Med Univ, Sch Med, Lab Anim Res Ctr, Mibu, Tochigi, Japan.
   [Suzi, Noriko] Dokkyo Med Univ, Sch Med, Inst Med Sci, Mibu, Tochigi, Japan.
C3 Dokkyo Medical University; Dokkyo Medical University; Dokkyo Medical
   University
RP Kobayashi, N (corresponding author), Dokkyo Med Univ, Sch Med, Dept Hypertens & Cardiorenal Med, Mibu, Tochigi, Japan.
EM nao-koba@dokkyomed.ac.jp
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NR 24
TC 92
Z9 100
U1 0
U2 1
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0895-7061
EI 1941-7225
J9 AM J HYPERTENS
JI Am. J. Hypertens.
PD MAY
PY 2008
VL 21
IS 5
BP 576
EP 581
DI 10.1038/ajh.2008.27
PG 6
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 288TP
UT WOS:000255009000021
PM 18437150
DA 2025-06-11
ER

PT J
AU Hu, MQ
   Wei, KZ
   Wu, SY
   Zhang, X
   Zhang, XT
   Xu, X
   Shen, XH
   Gao, JP
AF Hu, Ming-Qiao
   Wei, Ke-Zhao
   Wu, Shi-Yu
   Zhang, Xu
   Zhang, Xiao-Ting
   Xu, Xu
   Shen, Xu-Hua
   Gao, Jian-Ping
TI Cinnamaldehyde Attenuates Diabetic Cardiomyopathy by Ameliorating Energy
   Metabolism Disturbance and Activating Autophagy
SO JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
LA English
DT Article
DE diabetic cardiomyopathy; cinnamaldehyde; hyperglycemia; cardiac
   hypertrophy; energy metabolism abnormalities; autophagy
ID CELL-DEATH; OXIDATIVE STRESS; AMPK; PHOSPHORYLATION; HEART; MTOR; LC3;
   ATP
AB Diabetic cardiomyopathy (DCM) is a diabetes mellitus-induced pathophysiologic condition that can lead to heart failure. Cinnamaldehyde (CA), a bioactive phytochemical derived from the bark of Cinnamon, exhibits cardioprotective properties against heart injury in metabolic syndrome. This study aims to explore the role of CA on DCM and its cardioprotective mechanisms. Diabetic rats were established by injection of streptozotocin (STZ, 60-85 mg/kg). Subsequently, CA (50 mg/kg) was administered through gavage daily for 28-day duration. After this treatment, abnormality levels of fasting blood glucose, triglyceride, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio were ameliorated. In addition, CA inhibited cardiac histopathologic alterations and hypertrophy, reduced brain natriuretic peptide level, shortened S-T and P-R intervals on electrocardiogram, decreased tissue malondialdehyde content, and enhanced myocardial energy metabolism, including creatine (Cr), adenosine triphosphate, adenosine monophosphate (AMP), and total adenine nucleotides. Furthermore, CA improved oxidative stress, improved myocardial Ca2+-Mg2+-adenosine triphosphatase activity, and downregulated the mRNA expression of AMP protein activation kinase alpha 2 (AMPK-alpha 2), receptor gamma coactivator-1 alpha (PGC-1 alpha), and peroxisome proliferator-activated receptor alpha, while also ameliorating protein expression levels, including ratio of phosphorylated mammalian target of rapamycin to mechanistic target of rapamycin (p-mTOR/mTOR), level of SQSTM1/p62, and ratio of microtubule-associated protein 1 light chain 3 beta to microtubule-associated protein 1 light chain 3 alpha (LC3II/LC3I). In conclusion, these findings indicate that CA can alleviate DCM by modulating AMPK-alpha 2/PPAR-alpha/PGC-1 alpha signaling pathway to restore energy metabolism and activating autophagy through mTOR signaling pathway.
C1 [Hu, Ming-Qiao; Wei, Ke-Zhao; Zhang, Xu; Zhang, Xiao-Ting; Shen, Xu-Hua; Gao, Jian-Ping] Shanghai Univ Tradit Chinese Med, Sch Pharm, Dept Pharmacol, 1200 Cailun Rd, Shanghai 201203, Peoples R China.
   [Wu, Shi-Yu; Xu, Xu] Shanghai Inst Technol, Sch Chem & Environm Engn, Shanghai, Peoples R China.
C3 Shanghai University of Traditional Chinese Medicine; Shanghai Institute
   of Technology
RP Gao, JP (corresponding author), Shanghai Univ Tradit Chinese Med, Sch Pharm, Dept Pharmacol, 1200 Cailun Rd, Shanghai 201203, Peoples R China.
EM 1959114538@qq.com; 15608223560@163.com; 779435384@qq.com;
   1392474583@qq.com; 1520605145@qq.com; xuxu3426@sina.com;
   yaolisxh@163.com; jianpinggao@shutcm.edu.cn
FU National Natural Science Foundation of China [82074055]; Budget
   Scientific Research Project of Shanghai University of Traditional
   Chinese Medicine [2020LK016]
FX This work is financially supported by the National Natural Science
   Foundation of China (Grant No. 82074055) and the Budget Scientific
   Research Project of Shanghai University of Traditional Chinese
   Medicine(Grant No. 2020LK016).
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NR 54
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0160-2446
EI 1533-4023
J9 J CARDIOVASC PHARM
JI J. Cardiovasc. Pharmacol.
PD JUN
PY 2025
VL 85
IS 6
BP 428
EP 438
DI 10.1097/FJC.0000000000001694
PG 11
WC Cardiac & Cardiovascular Systems; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Pharmacology & Pharmacy
GA 3KJ8A
UT WOS:001502443900001
PM 40153313
DA 2025-06-11
ER

PT J
AU Lages, M
   Carmo-Silva, S
   Barros, R
   Guarino, MP
AF Lages, Marlene
   Carmo-Silva, Sara
   Barros, Renata
   Guarino, Maria Pedro
TI Effects of time-restricted eating on body composition, biomarkers of
   metabolism, inflammation, circadian system and oxidative stress in
   overweight and obesity: an exploratory review
SO PROCEEDINGS OF THE NUTRITION SOCIETY
LA English
DT Review; Early Access
DE Circadian rhythm; Chrononutrition; Biomarkers; Mealtime; Metabolism;
   Metabolic syndrome; Obesity
ID WEIGHT-LOSS; CLOCK GENE; HEALTH; MORTALITY; DISEASE; GLUCOSE; RODENTS;
   MEALS
AB Obesity is a chronic, complex and multi-factorial condition with an increasing prevalenceworldwide. Irregular eating schedules might be a contributing factor to these numbers throughthe dysregulation of the circadian system. Time-restricted eating (TRE), an approach that limitseating windows, has been studied as a strategy to treat obesity, aligning eating occasions withmetabolic circadian rhythms. This review aims to provide an overview of the impact of TREprotocols on metabolic, inflammatory, oxidative stress and circadian rhythm biomarkers inpeople with overweight or obesity. Most studies report significant weight loss following TREprotocols. While glucose levels decreased in nearly all TRE interventions, only a few studiesdemonstrated statistically significant differences when compared to the control groups. Thefindings for c-reactive protein and TNF-alpha were inconsistent, with limited significantdifferences. Changes in lipid profile changes were variable and generally did not reach statisticalsignificance. Both 4-hour and 6-hour TRE interventions significantly reduced 8-isoprostanelevels. Additionally, TRE significantly altered clock gene expression, as well as that of genesassociated with metabolic regulation in subcutaneous adipose tissue. While the evidence is stillinconsistent, limiting eating to a consistent daily window of 8 to 12 h can improve insulinsensitivity, reduce blood glucose, cholesterol and triglyceride levels and promote weight loss.These effects are likely attributable to both direct metabolic impacts and indirect benefits fromweight loss and improved dietary habits. However, data on circadian, inflammatory and specificmetabolic biomarkers remain scarce and occasionally contradictory, highlighting the need forfurther research on these interventions.
C1 [Lages, Marlene; Carmo-Silva, Sara; Guarino, Maria Pedro] Polytech Univ Leiria, ciTechCare Ctr Innovat Care & Hlth Technol, Leiria, Portugal.
   [Lages, Marlene; Barros, Renata] Univ Porto, Fac Nutr & Food Sci, Porto, Portugal.
   [Lages, Marlene; Barros, Renata] Univ Porto, Lab Integrat & Translat Res Populat Hlth ITR, Porto, Portugal.
   [Lages, Marlene; Barros, Renata] Univ Porto, EPIUnit Inst Publ Hlth, Porto, Portugal.
   [Carmo-Silva, Sara] Polytech Univ Coimbra, Coimbra, Portugal.
   [Carmo-Silva, Sara] Polytech Univ Coimbra, H&TRC Hlth & Technol Res Ctr, Coimbra Hlth Sch, Coimbra, Portugal.
   [Guarino, Maria Pedro] Polytech Univ Leiria, Sch Hlth Sci, ESSLei, Leiria, Portugal.
C3 Universidade do Porto; Universidade do Porto; Universidade do Porto
RP Lages, M (corresponding author), Polytech Univ Leiria, ciTechCare Ctr Innovat Care & Hlth Technol, Leiria, Portugal.; Lages, M (corresponding author), Univ Porto, Fac Nutr & Food Sci, Porto, Portugal.; Lages, M (corresponding author), Univ Porto, Lab Integrat & Translat Res Populat Hlth ITR, Porto, Portugal.; Lages, M (corresponding author), Univ Porto, EPIUnit Inst Publ Hlth, Porto, Portugal.
EM marlene.c.lages@ipleiria.pt
RI Lages, Marlene/ABH-6175-2022; Carmo-Silva, Sara/AAE-7641-2020; Guarino,
   Maria/B-5594-2015; Barros, Renata/AGC-2171-2022
OI Barros, Renata/0000-0002-3043-1720; Lages, Marlene/0000-0002-7389-6368
FU Portuguese national funds provided by FCT-Fundacao para a Ciencia e
   Tecnologia, I.P. [UI/05704/2020]; Portuguese Society of Diabetology
   through the award of the 2020 Emilio Peres Scholarship; Faculty of
   Nutrition and Food Sciences of the University of Porto and LabITR
   [LA/P/0064/2020]; FCT-Fundacao para a Ciencia e Tecnologia, I.P.;
   National funds through FCT-Fundacao para a Ciencia e Tecnologia, I.P.
FX This work was supported by Portuguese national funds provided by
   FCT-Fundacao para a Ciencia e Tecnologia, I.P., (UI/05704/2020), by the
   Portuguese Society of Diabetology through the award of the 2020 Emilio
   Peres Scholarship and by the Faculty of Nutrition and Food Sciences of
   the University of Porto and LabITR (LA/P/0064/2020). ML is supported by
   a PhD Scholarship from the FCT-Fundacao para a Ciencia e Tecnologia,
   I.P. (DOI 10<middle dot>54499/2021<middle dot>07673.BD). MPG work is
   funded by national funds through FCT-Fundacao para a Ciencia e
   Tecnologia, I.P., under the Scientific Employment Stimulus-Institutional
   Call (DOI 10<middle dot>54 499/CEECINST/00051/2018/CP1566/CT0009).
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NR 73
TC 1
Z9 1
U1 5
U2 6
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0029-6651
EI 1475-2719
J9 P NUTR SOC
JI Proc. Nutr. Soc.
PD 2024 NOV 20
PY 2024
DI 10.1017/S002966512400747X
EA NOV 2024
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA R5U7Q
UT WOS:001392103900001
PM 39563167
OA Bronze
DA 2025-06-11
ER

PT J
AU Rojo, M
   Pérez, H
   Millán, AL
   Pautasso, MC
   Frechtel, GD
   Cerrone, GE
AF Rojo, Mailen
   Perez, Hernan
   Millan, Andrea Liliana
   Pautasso, Maria Constanza
   Frechtel, Gustavo Daniel
   Cerrone, Gloria Edith
TI Relationship of Mitochondrial DNA Oxidation and Content with Metabolic
   Syndrome and Cardiovascular Risk in Obesity Phenotypes
SO JOURNAL OF OBESITY
LA English
DT Article
ID COPY NUMBER; INSULIN-RESISTANCE; FISSION; FUSION; RATIO
AB Objective. Obesity, chronic inflammation, and oxidative stress can influence mitochondrial DNA (mtDNA) content. Our objective was to evaluate the oxidation level and content of mtDNA and its relationship with metabolic parameters in metabolically healthy obese (MHO) compared to metabolically unhealthy obese (MUO) and normal weight (NW) controls. Materials and Methods. We studied 94 NW, 95 MHO, and 97 MUO individuals between 18 and 80 years old. Relative mtDNA content and mtDNA oxidation level (8-oxoguanine, 8-OxoG) were determined in peripheral blood leukocytes by the SYBR Green method of real-time PCR. One-way ANOVA and Tukey test were used to compare biochemical, clinical, and anthropometric characteristics, as well as mtDNA content and 8-OxoG. Results. A progressive decrease in mtDNA content was observed between NW, MHO, and MUO with significant differences in MUO vs. NW (p: 0.04). An increase in 8-OxoG was observed in MUO patients compared to the other groups (MUO vs. MHO p: 0.01; MUO vs. NW p: 0.04). mtDNA content was directly correlated with HDL-c (p<0.01) and inversely with waist circumference (p: 0.01) and LDL-c (p: 0.05). mtDNA content decreased, and the oxidation level increased concomitantly with the presence of obesity, the number of MS components, higher coronary risk, and insulin resistance parameters. Conclusion. MHO presented a similar mtDNA oxidation level to NW and mtDNA content to the MUO, placing the MHO individuals as having an intermediate phenotype. Changes in mtDNA content and oxidation were correlated to the lipid profile related to obesity and/or MS presence, probably associated with oxidative stress and chronic low-grade inflammation.
C1 [Rojo, Mailen; Millan, Andrea Liliana; Cerrone, Gloria Edith] Univ Buenos Aires, Fac Farm & Bioquim, Dept Microbiol Inmunol Biotecnol & Genet, Buenos Aires, Argentina.
   [Rojo, Mailen; Perez, Hernan; Millan, Andrea Liliana; Pautasso, Maria Constanza; Frechtel, Gustavo Daniel; Cerrone, Gloria Edith] Univ Buenos Aires, CONICET, Inst Inmunol Genet & Metab INIGEM, Buenos Aires, Argentina.
   [Perez, Hernan; Frechtel, Gustavo Daniel] Hosp Clin Jose San Martin, Serv Nutr, Buenos Aires, Argentina.
   [Frechtel, Gustavo Daniel] Inst Univ Ciencias Salud, Fdn Hctor Alejandro H A Barcelo, Buenos Aires, Argentina.
C3 University of Buenos Aires; Consejo Nacional de Investigaciones
   Cientificas y Tecnicas (CONICET); University of Buenos Aires; University
   of Buenos Aires; Hospital de Clinicas Jose de San Martin; University of
   Buenos Aires Hospital
RP Cerrone, GE (corresponding author), Univ Buenos Aires, Fac Farm & Bioquim, Dept Microbiol Inmunol Biotecnol & Genet, Buenos Aires, Argentina.; Cerrone, GE (corresponding author), Univ Buenos Aires, CONICET, Inst Inmunol Genet & Metab INIGEM, Buenos Aires, Argentina.
EM maailen.rojo@gmail.com; hernanperez82@gmail.com;
   lic.andreamillan@gmail.com; mcpautasso@gmail.com; gfrechtel@yahoo.com;
   gcerrone@ffyb.uba.ar
OI Cerrone, Gloria/0000-0003-1217-8132; Rojo, Mailen/0009-0008-5336-9430
FU Universidad de Buenos Aires [20020190100227BA/2020]; Agencia Nacional de
   Promocion Cientifica y Tecnologica [PID2017-0029]
FX This study complemented the Venado Tuerto III study. The authors are
   very grateful to the volunteers who consented to participate in this
   study. The authors also thank Dr. Hugo Grancelli, Dra. Monica Damiano,
   Dr. Daniel Fox, Dr. Carlos Ranalli, Dr. Vilarino J dagger, the Regional
   Centre for Development, the School of Social Work of Venado Tuerto, the
   Nutrition Society of Venado Tuerto, and the Department of Cardiology
   Hospital Alejandro Gutierrez of Venado Tuerto for their collaboration.
   This work was supported by grants from Universidad de Buenos Aires
   (20020190100227BA/2020) to G.E.C. and by Agencia Nacional de Promocion
   Cientifica y Tecnologica (PID2017-0029) to G.D.F.
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NR 43
TC 1
Z9 1
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2090-0708
EI 2090-0716
J9 J OBES
JI J. Obes.
PD SEP 11
PY 2024
VL 2024
AR 3008093
DI 10.1155/2024/3008093
PG 11
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA G7N9G
UT WOS:001318470600001
PM 39297082
OA gold
DA 2025-06-11
ER

PT J
AU Osaki, A
   Kagami, K
   Ishinoda, Y
   Sato, A
   Kimura, T
   Horii, S
   Ito, K
   Toya, T
   Ido, Y
   Namba, T
   Masaki, N
   Nagatomo, Y
   Adachi, T
AF Osaki, Ayumu
   Kagami, Kazuki
   Ishinoda, Yuki
   Sato, Atsushi
   Kimura, Toyokazu
   Horii, Shunpei
   Ito, Kei
   Toya, Takumi
   Ido, Yasuo
   Namba, Takayuki
   Masaki, Nobuyuki
   Nagatomo, Yuji
   Adachi, Takeshi
TI Reactive Oxygen Species in the Aorta and Perivascular Adipose Tissue
   Precedes Endothelial Dysfunction in the Aorta of Mice with a High-Fat
   High-Sucrose Diet and Additional Factors
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE type 2 diabetes mellitus; steatohepatitis; hypercholesterolemia;
   perivascular adipose tissue; endothelial dysfunction; oxidative stress
ID NITRIC-OXIDE; LIVER-DISEASE; OXIDATIVE STRESS; INSULIN;
   HYPERCHOLESTEROLEMIA; RESISTANCE; DEFICIENT; FIBROSIS; SENSITIVITY;
   APOPTOSIS
AB Metabolic syndrome (Mets) is the major contributor to the onset of metabolic complications, such as hypertension, type 2 diabetes mellitus (DM), dyslipidemia, and non-alcoholic fatty liver disease, resulting in cardiovascular diseases. C57BL/6 mice on a high-fat and high-sucrose diet (HFHSD) are a well-established model of Mets but have minor endothelial dysfunction in isolated aortas without perivascular adipose tissue (PVAT). The purpose of this study was to evaluate the effects of additional factors such as DM, dyslipidemia, and steatohepatitis on endothelial dysfunction in aortas without PVAT. Here, we employed eight-week-old male C57BL/6 mice fed with a normal diet (ND), HFHSD, steatohepatitis choline-deficient HFHSD (HFHSD-SH), and HFHSD containing 1% cholesterol and 0.1% deoxycholic acid (HFHSD-Chol) for 16 weeks. At week 20, some HFHSD-fed mice were treated with streptozocin to develop diabetes (HFHSD-DM). In PVAT-free aortas, the endothelial-dependent relaxation (EDR) did not differ between ND and HFHSD (p = 0.25), but in aortas with PVAT, the EDR of HFHSD-fed mice was impaired compared with ND-fed mice (p = 0.005). HFHSD-DM, HFHSD-SH, and HFHSD-Chol impaired the EDR in aortas without PVAT (p < 0.001, p = 0.019, and p = 0.009 vs. ND, respectively). Furthermore, tempol rescued the EDR in those models. In the Mets model, the EDR is compromised by PVAT, but with the addition of DM, dyslipidemia, and SH, the vessels themselves may result in impaired EDR.
C1 [Osaki, Ayumu; Kagami, Kazuki; Ishinoda, Yuki; Sato, Atsushi; Kimura, Toyokazu; Horii, Shunpei; Ito, Kei; Toya, Takumi; Ido, Yasuo; Namba, Takayuki; Masaki, Nobuyuki; Nagatomo, Yuji; Adachi, Takeshi] Natl Def Med Coll, Dept Internal Med 1, Div Cardiovasc Med, 3-2 Namiki, Tokorozawa 3598513, Japan.
C3 National Defense Medical College - Japan
RP Nagatomo, Y; Adachi, T (corresponding author), Natl Def Med Coll, Dept Internal Med 1, Div Cardiovasc Med, 3-2 Namiki, Tokorozawa 3598513, Japan.
EM con401@ndmc.ac.jp; tadachibu@gmail.com
RI Nagatomo, Yuji/AAQ-1590-2020
OI Masaki, Nobuyuki/0000-0002-4426-3692; KAGAMI,
   KAZUKI/0000-0002-1743-4409; sato, atsushi/0000-0002-2138-3173; Kimura,
   Toyokazu/0000-0002-1347-5115; Nagatomo, Yuji/0000-0002-3430-4614
FU Japanese Ministry of Defense; MEXT/JSPS KAKENHI Research Fund of the
   Mitsukoshi Health and Welfare Foundation [JP 17K09596, 17K09565,
   JP18H02815]
FX This research was funded by grants from the Japanese Ministry of Defense
   and a MEXT/JSPS KAKENHI Grant-in-Aid for Scientific Research (Number JP
   17K09596, 17K09565, and JP18H02815) from the Research Fund of the
   Mitsukoshi Health and Welfare Foundation.
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NR 43
TC 3
Z9 3
U1 1
U2 1
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD APR
PY 2023
VL 24
IS 7
AR 6486
DI 10.3390/ijms24076486
PG 15
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA D7EC1
UT WOS:000970311000001
PM 37047458
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Westfall, S
   Lomis, N
   Kahouli, I
   Dia, SY
   Singh, SP
   Prakash, S
AF Westfall, Susan
   Lomis, Nikita
   Kahouli, Imen
   Dia, Si Yuan
   Singh, Surya Pratap
   Prakash, Satya
TI Microbiome, probiotics and neurodegenerative diseases: deciphering the
   gut brain axis
SO CELLULAR AND MOLECULAR LIFE SCIENCES
LA English
DT Review
DE Gut microbiota; Probiotics; Gut-brain-axis; Neurodegeneration; Oxidative
   stress; Short-chain fatty acids
ID CHAIN FATTY-ACIDS; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; EXACERBATE
   NEUROLOGICAL SYMPTOMS; VAGUS NERVE-STIMULATION; ALZHEIMERS-DISEASE;
   FERULIC ACID; PARKINSONS-DISEASE; BIFIDOBACTERIUM-BREVE; QUINOLINIC
   ACID; INDOLEAMINE 2,3-DIOXYGENASE
AB The gut microbiota is essential to health and has recently become a target for live bacterial cell biotherapies for various chronic diseases including metabolic syndrome, diabetes, obesity and neurodegenerative disease. Probiotic biotherapies are known to create a healthy gut environment by balancing bacterial populations and promoting their favorable metabolic action. The microbiota and its respective metabolites communicate to the host through a series of biochemical and functional links thereby affecting host homeostasis and health. In particular, the gastrointestinal tract communicates with the central nervous system through the gut-brain axis to support neuronal development and maintenance while gut dysbiosis manifests in neurological disease. There are three basic mechanisms that mediate the communication between the gut and the brain: direct neuronal communication, endocrine signaling mediators and the immune system. Together, these systems create a highly integrated molecular communication network that link systemic imbalances with the development of neurodegeneration including insulin regulation, fat metabolism, oxidative markers and immune signaling. Age is a common factor in the development of neurodegenerative disease and probiotics prevent many harmful effects of aging such as decreased neurotransmitter levels, chronic inflammation, oxidative stress and apoptosis-all factors that are proven aggravators of neurodegenerative disease. Indeed patients with Parkinson's and Alzheimer's diseases have a high rate of gastrointestinal comorbidities and it has be proposed by some the management of the gut microbiota may prevent or alleviate the symptoms of these chronic diseases.
C1 [Westfall, Susan; Lomis, Nikita; Kahouli, Imen; Dia, Si Yuan; Prakash, Satya] McGill Univ, Fac Med, Dept Biomed Engn, Biomed Technol & Cell Therapy Res Lab, 3775 Univ St, Montreal, PQ H3A2B4, Canada.
   [Lomis, Nikita; Kahouli, Imen; Prakash, Satya] McGill Univ, Fac Med, Dept Expt Med, 3775 Univ St, Montreal, PQ H3A2B4, Canada.
   [Singh, Surya Pratap] Banaras Hindu Univ, Dept Biochem, Varanasi 221005, Uttar Pradesh, India.
C3 McGill University; McGill University; Banaras Hindu University (BHU)
RP Prakash, S (corresponding author), McGill Univ, Fac Med, Dept Biomed Engn, Biomed Technol & Cell Therapy Res Lab, 3775 Univ St, Montreal, PQ H3A2B4, Canada.; Prakash, S (corresponding author), McGill Univ, Fac Med, Dept Expt Med, 3775 Univ St, Montreal, PQ H3A2B4, Canada.
EM susan.westfall@mail.mcgill.ca; nikita.lomis@mail.mcgill.ca;
   siyuandai@hotmail.com; suryasingh@hotmail.com; satya.prakash@mcgill.ca
RI Singh, Saumitra Sen/AAG-6914-2019
OI Singh, Surya/0000-0001-5668-1712; /0000-0002-4902-2353
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NR 203
TC 367
Z9 409
U1 1
U2 237
PU SPRINGER BASEL AG
PI BASEL
PA PICASSOPLATZ 4, BASEL, 4052, SWITZERLAND
SN 1420-682X
EI 1420-9071
J9 CELL MOL LIFE SCI
JI Cell. Mol. Life Sci.
PD OCT
PY 2017
VL 74
IS 20
BP 3769
EP 3787
DI 10.1007/s00018-017-2550-9
PG 19
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA FG6VI
UT WOS:000410533600007
PM 28643167
OA Green Published
DA 2025-06-11
ER

PT J
AU Vecka, M
   Dusejovská, M
   Stanková, B
   Zeman, M
   Vávrová, L
   Kodydková, J
   Slaby, A
   Zák, A
AF Vecka, Marek
   Dusejovska, Magdalena
   Stankova, Barbora
   Zeman, Miroslav
   Vavrova, Lucie
   Kodydkova, Jana
   Slaby, Adolf
   Zak, Ales
TI N-3 polyunsaturated fatty acids in the treatment of atherogenic
   dyslipidemia
SO NEUROENDOCRINOLOGY LETTERS
LA English
DT Article
DE residual cardiovascular risk; atherogenic dyslipidemia; n-3 PUFA
ID METABOLIC SYNDROME; OXIDATIVE STRESS; HEART-DISEASE; PLASMA; RISK;
   LIPOPROTEINS; CHOLESTEROL; OMEGA-3-FATTY-ACIDS; SUPPLEMENTATION;
   CHROMATOGRAPHY
AB BACKGROUND: Atherogenic dyslipidemia contributes substantially to the residual cardiovascular risk. The aim of this study was to examine the effects of therapeutic doses of n-3 polyunsaturated fatty acids on the three major lipid abnormalities of atherogenic dyslipidemia, i.e. hypertriacylglycerolemia, low HDL cholesterol, and increased levels of small dense LDL particles, as well as on some new risk factors.
   MATERIALS AND METHODS: A total of 60 hypertriacylglycerolemic patients were included in the study. Group S consisted of 36 patients who were already treated with statins, Group N of 24 patients not yet treated. Each patient was examined after six weeks on placebo and six weeks of treatment with n-3 PUFA (eicosapentaenoic and docosahexaenoic acid ethyl esters, 3.0 g/d).
   RESULTS: Treatment with n-3 PUFA caused a decrease in plasma triacylglycerols (28%, p<0.001), and VLDL (-27%, p<0.001), an increase in HDL-C (+4%, p<0.01), and a decrease in sdLDL cholesterol (-16%,p<0.05). These changes were accompanied by a decrease in microalbuminuria (-30%, p<0.05), as well as in several parameters of oxidative stress. Analysis of the fatty acids composition of plasma phospholipids showed a significant increase in all n-3 PUFAs examined, accompanied by a decrease in n-6 PUFAs, as well as in monounsaturated acids. No significant differences in the effects of n-3 PUFA were found between the Groups S and N.
   CONCLUSION: Our results support the opinion that hypertriacylglycerolemic patients benefit from the treatment with n-3 PUFA which improves several important metabolic factors of cardiovascular risk.
C1 [Vecka, Marek] Charles Univ Prague, Fac Med 1, Dept Internal Med 4, Prague 12808 2, Czech Republic.
   Gen Teaching Hosp, Prague 12808 2, Czech Republic.
C3 Charles University Prague; General University Hospital Prague
RP Vecka, M (corresponding author), Charles Univ Prague, Fac Med 1, Dept Internal Med 4, U Nemocnice 2, Prague 12808 2, Czech Republic.
EM marvec@volny.cz
RI Slaby, Adolf/P-5060-2016; Vavrova, Lucie/D-7030-2017; Rychlikova,
   Jana/A-2531-2015; Dusejovska, Magdalena/R-1051-2016; Zeman,
   Miroslav/J-5281-2016; Zak, Ales/G-8318-2016; Vecka, Marek/A-3560-2008
OI Slaby, Adolf/0000-0003-3036-1221; Rychlikova, Jana/0000-0002-6961-5260;
   Dusejovska, Magdalena/0000-0003-3599-006X; Zeman,
   Miroslav/0000-0001-5338-603X; Zak, Ales/0000-0002-1698-6068; Vecka,
   Marek/0000-0002-3269-1817
FU Charles University in Prague, First Faculty of Medicine
   [PRVOUK-P25/LF1/2];  [SVV-2011-262513]
FX The work was supported by the grants SVV-2011-262513 and Research
   project of Charles University in Prague, First Faculty of Medicine -
   PRVOUK-P25/LF1/2
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NR 34
TC 14
Z9 19
U1 0
U2 14
PU MAGHIRA & MAAS PUBLICATIONS
PI MUNSBACH
PA MAGHIRA & MAAS S A R L, 6C, RUE GABRIEL LIPPMANN, L-5365 MUNSBACH,
   LUXEMBOURG
SN 0172-780X
J9 NEUROENDOCRINOL LETT
JI Neuroendocrinol. Lett.
PY 2012
VL 33
SU 2
BP 87
EP 92
PG 6
WC Endocrinology & Metabolism; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology
GA 052CN
UT WOS:000312175400017
PM 23183517
DA 2025-06-11
ER

PT J
AU Xiao, L
   Aoshima, H
   Saitoh, Y
   Miwa, N
AF Xiao, Li
   Aoshima, Hisae
   Saitoh, Yasukazu
   Miwa, Nobuhiko
TI The effect of squalane-dissolved fullerene-C60 on
   adipogenesis-accompanied oxidative stress and macrophage activation in a
   preadipocyte-monocyte co-culture system
SO BIOMATERIALS
LA English
DT Article
DE Nanoparticle; Co-culture; Adipose-tissue engineering; Inflammation
ID INSULIN-RESISTANCE; ADIPOSE-TISSUE; APOPTOTIC DEATH; OBESITY;
   INFLAMMATION; CELLS; CYTOTOXICITY; ADIPOCYTES; PROTEIN-1; DISEASE
AB Effects of squalane-dissolved fullerene-C60 (Sql-fullerene) on macrophage activation and adipose conversion with oxidative stress were studied using an inflammatory adipose-tissue equivalent (ATE) and OP9 mouse stromal preadipocyte-U937 lymphoma cell co-culture systems. Differentiation of OP9 cells was initiated by insulin-rich serum replacement (SR) as an adipogenic stimulant, and then followed by accumulation of intracellular lipid droplets and reactive oxygen species (ROS), both of which were significantly inhibited by Sql-fullerene. In the OP9-U937 cell co-culture system, U937 cells rapidly differentiated to macrophage-like cells during SR-induced adipogenesis in OP9 cells. The ROS accumulation was in the co-culture more marked than in OP9 cells alone, suggesting that the interaction between adipocytes and monocytes/macrophages promotes inflammatory responses. Sql-fullerene significantly inhibited macrophage activation and low-grade adipogenesis in the OP9-U937 co-culture system. We developed a three-dimensional inflammatory adipose-tissue model "ATE" consisting of, characteristically, U937 cells in the culture-wells, and, in addition, mounted a culture insert containing OP9 cells-populated collagen gel. ATE is enabled with suitable stimulation to represent the pathology of inflammatory disorders, such as macrophage infiltration in adipose tissue. Five-day culturing of ATE in SR medium occurred U937 macrophage migration and intracellular oil-droplet accumulation that were significantly inhibited by Sql-fullerene. Our results suggest that Sql-fullerene might be explored as a potential medicine for the treatment of metabolic syndrome or other obesity-related disorders. (C) 2010 Elsevier Ltd. All rights reserved.
C1 [Xiao, Li; Saitoh, Yasukazu; Miwa, Nobuhiko] Prefectural Univ Hiroshima, Lab Cell Death Control BioTechnol, Fac Life & Environm Sci, Hiroshima 7270023, Japan.
   [Aoshima, Hisae] Vitamin C60 BioRes Corp, Chuo Ku, Tokyo 1030028, Japan.
RP Miwa, N (corresponding author), Prefectural Univ Hiroshima, Lab Cell Death Control BioTechnol, Fac Life & Environm Sci, Nanatsuka 562, Hiroshima 7270023, Japan.
EM miwa-nob@pu-hiroshima.ac.jp
RI saitoh, yasukazu/AAQ-6432-2021; Xiao, Li/AAX-7766-2020
OI Xiao, Li/0000-0002-3053-4930; Saitoh, Yasukazu/0000-0002-6288-7634
FU NEDO (New Energy and Industrial technology Development Organization)
FX This study was in part financially supported by a grant to N.M. of the
   Research and Development Project of Industrial Scienceand Technology
   Frontier Program from NEDO (New Energy and Industrial technology
   Development Organization).
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NR 39
TC 35
Z9 37
U1 0
U2 26
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0142-9612
EI 1878-5905
J9 BIOMATERIALS
JI Biomaterials
PD AUG
PY 2010
VL 31
IS 23
BP 5976
EP 5985
DI 10.1016/j.biomaterials.2010.04.032
PG 10
WC Engineering, Biomedical; Materials Science, Biomaterials
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering; Materials Science
GA 623DZ
UT WOS:000279719600008
PM 20488530
DA 2025-06-11
ER

PT J
AU Poudyal, H
   Campbell, F
   Brown, L
AF Poudyal, Hemant
   Campbell, Fiona
   Brown, Lindsay
TI Olive Leaf Extract Attenuates Cardiac, Hepatic, and Metabolic Changes in
   High Carbohydrate-, High Fat-Fed Rats
SO JOURNAL OF NUTRITION
LA English
DT Article
ID OLEA-EUROPAEA; BIOLOGICAL-ACTIVITIES; RICH EXTRACTS; OIL; ANTIOXIDANT;
   OLEUROPEIN; DISEASE; MALONDIALDEHYDE; HYPERTENSION; POLYPHENOLS
AB Olive oil, an important component of the Mediterranean diet, produces cardioprotective effects, probably due to both oleic acid and the polyphenols such as oleuropein and hydroxytyrosol. Our aim in this study was to assess whether a polyphenol-enriched extract from the leaves of Olea europaea L. with oleuropein as the major component attenuated the cardiovascular, hepatic, and metabolic signs of a high-carbohydrate, high-fat (HCHF) diet (carbohydrate, 52%; fat, 24%, 25% fructose in drinking water) in rats. Male Wistar rats were fed either a cornstarch diet (CS) or a HCHF diet for a total of 16 wk. Diets of the treatment groups [CS+olive leaf extract (OLE) and HCHF+OLE] were supplemented with 3% OLE after 8 wk of being fed their respective CS or HCHF diets for a further 8 wk. After 16 wk, HCHF rats developed signs of metabolic syndrome, including elevated abdominal and hepatic fat deposition, collagen deposition in heart and liver, cardiac stiffness, and oxidative stress markers (plasma malondialdehyde and uric acid concentrations), with diminished aortic ring reactivity, abnormal plasma lipid profile, impaired glucose tolerance, and hypertension. Compared with HCHF rats, those in the HCHF+OLE group had improved or normalized cardiovascular, hepatic, and metabolic signs with the exception of elevated blood pressure. These results strongly suggest that an OLE containing polyphenols such as oleuropein and hydroxytyrosol reverses the chronic inflammation and oxidative stress that induces the cardiovascular, hepatic, and metabolic symptoms in this rat model of diet-induced obesity and diabetes without changing blood pressure. J. Nutr. 140: 946-953, 2010.
C1 [Poudyal, Hemant; Brown, Lindsay] Univ Queensland, Sch Biomed Sci, Brisbane, Qld 4072, Australia.
   [Campbell, Fiona] Univ Queensland, Sch Vet Sci, Brisbane, Qld 4072, Australia.
C3 University of Queensland; University of Queensland
RP Brown, L (corresponding author), Univ Queensland, Sch Biomed Sci, Brisbane, Qld 4072, Australia.
EM lindsay.brown@usq.edu.au
RI Poudyal, Hemant/HOH-9324-2023
FU Dr. Red Nutraceuticals, Australia
FX Supported by Dr. Red Nutraceuticals, Australia.
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NR 45
TC 215
Z9 235
U1 1
U2 48
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0022-3166
EI 1541-6100
J9 J NUTR
JI J. Nutr.
PD MAY
PY 2010
VL 140
IS 5
BP 946
EP 953
DI 10.3945/jn.109.117812
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 589CI
UT WOS:000277121800011
PM 20335636
OA Bronze
DA 2025-06-11
ER

PT J
AU Perdomo, G
   Dong, HH
AF Perdomo, German
   Dong, H. Henry
TI Apolipoprotein D in lipid metabolism and its functional implication in
   atherosclerosis and aging
SO AGING-US
LA English
DT Review
DE ApoD; HDL; LDL; VLDL; Dyslipidemia; Obesity; Diabetes; Atherosclerosis;
   Aging
ID LECITHIN-CHOLESTEROL ACYLTRANSFERASE; CASSETTE TRANSPORTER 1;
   HUMAN-PLASMA LECITHIN; NIEMANN-PICK-DISEASE; TANGIER-DISEASE;
   GENETIC-VARIATION; ALZHEIMERS-DISEASE; STRESS RESISTANCE; LIFE-SPAN;
   INCREASED EXPRESSION
AB Dyslipidemia is characterized by increased triglyceride and low-density lipoprotein (LDL) levels, and decreased high-density lipoprotein (HDL) levels. Such an atherogenic lipid profile often predisposes an at risk individual to coronary artery disease with incompletely understood mechanisms. Apolipoprotein D (apoD) is an atypical apolipoprotein. Unlike canonical apolipoproteins that are produced mainly in liver and intestine, apoD is expressed widely in mammalian tissues. ApoD does not share significant degrees of homology in amino acid sequence with other apolipoproteins. Instead, apoD is structurally similar to lipocalins, a diverse family of lipid-binding proteins that are responsible for transporting lipids and other small hydrophobic molecules for metabolism. Plasma ApoD is present mainly in HDL and to a lesser extent in low density lipoproteins (LDL) and very low-density lipoproteins (VLDL). Genetic variants of apoD are associated with abnormal lipid metabolism and increased risk of developing metabolic syndrome. Increased apoD deposition is detectable in atherosclerotic lesions of humans with established cardiovascular disease as well as mice with premature atherosclerosis. Moreover, apoD is associated with anti-oxidation and anti-stress activities, contributing to lifespan expansion in fruit flies. Elderly subjects and patients with Alzheimer exhibit markedly elevated apoD production in the brain. Thus, apoD is emerged as a significant player in lipid metabolism and aging. Here we focus our review on recent advances toward our understanding of apoD in lipid metabolism and address whether apoD dysregulation contributes to the pathogenesis of dyslipidemia and atherosclerosis. We will also discuss the functional implication of apoD in aging.
C1 [Perdomo, German; Dong, H. Henry] Univ Pittsburgh, Sch Med, Rangos Res Ctr,Childrens Hosp Pittsburgh, Div Immunogenet,Dept Pediat, Pittsburgh, PA 15213 USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE); University
   of Pittsburgh
RP Dong, HH (corresponding author), Univ Pittsburgh, Sch Med, Rangos Res Ctr,Childrens Hosp Pittsburgh, Div Immunogenet,Dept Pediat, 3460 5th Ave,Rm 5140, Pittsburgh, PA 15213 USA.
EM dongh@pitt.edu
RI ; Perdomo, German/K-6703-2014
OI Dong, Hengjiang Henry/0000-0003-0279-5241; Perdomo,
   German/0000-0002-2301-0012
FU American Diabetes Association and National Health Institute [DK066301]
FX This study was supported in part by American Diabetes Association and
   National Health Institute grant DK066301. We thank Dr. Steve Ringquist
   and members of the Dong Lab for critical proofreading of this
   manuscript.
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NR 80
TC 61
Z9 71
U1 0
U2 11
PU IMPACT JOURNALS LLC
PI ALBANY
PA 6211 TIPTON HOUSE, STE 6, ALBANY, NY 12203 USA
SN 1945-4589
J9 AGING-US
JI Aging-US
PD JAN
PY 2009
VL 1
IS 1
BP 17
EP 27
PG 11
WC Cell Biology; Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Geriatrics & Gerontology
GA 579DK
UT WOS:000276347200005
PM 19946382
DA 2025-06-11
ER

PT J
AU Kougias, P
   Chai, H
   Lin, PH
   Yao, QZ
   Lumsden, AB
   Chen, CY
AF Kougias, P
   Chai, H
   Lin, PH
   Yao, QZ
   Lumsden, AB
   Chen, CY
TI Effects of adipocyte-derived cytokines on endothelial functions:
   implication of vascular disease
SO JOURNAL OF SURGICAL RESEARCH
LA English
DT Review
DE adipocyte; adipokine; adipocytokine; leptin; adiponectin; resistin;
   endothelial function; vascular disease; atherosclerosis
ID C-REACTIVE PROTEIN; PLASMA-PROTEIN; NITRIC-OXIDE;
   CARDIOVASCULAR-DISEASE; INSULIN SENSITIVITY; ARTERIAL THROMBOSIS; LEPTIN
   LEVELS; DENSITY-LIPOPROTEIN; OXIDATIVE STRESS; GENE-EXPRESSION
AB Adipose tissue has recently emerged as an active endocrine organ that secretes a variety of metabolically important substances, collectively called adipocytokines or adipokines. In this review we summarize the effects of the adipokines leptin, adiponectin, and resistin on the vasculature and their potential role for pathogenesis of vascular disease. Leptin is associated with arterial wall thickness, decreased vessel distensibility, and elevated C reactive protein (CRP) levels. Leptin possesses procoagulant and antifibrinolytic properties, and it promotes thrombus and atheroma formation, probably through the leptin receptors by promoting vascular inflammation, proliferation, and calcification, and by increasing oxidative stress. Research for development of pharmacologic antagonism for the leptin receptor is currently under way. Adiponectin inhibits the expression of the adhesion molecules ICAM-1, VCAM-1, and P selectin. Therefore, it interferes with monocyte adherence to endothelial cells and their subsequent migration to the subendothelial space, one of the initial events in the development of atherosclerosis. Adiponectin also inhibits the transformation of macrophages to foam cells in vitro and decreases their phagocytic activity. Resistin, discovered in 2001, represents the newest of the adipokines and was named for its ability to promote insulin resistance. Resistin increases the expression of the adhesion molecules VCAM-1 and ICAM-1, up-regulates the monocyte chemoattractant chemokine-1, and promotes endothelial cell activation via ET-1 release. Although many aspects of its function need further clarification, it appears that resistin will add significantly to our knowledge of the pathophysiology of vascular disease and the metabolic syndrome. (C) 2005 Elsevier Inc. All rights reserved.
C1 Baylor Coll Med, Michael E DeBakey Dept Surg, Div Vasc Surg & Endovasc Therapy, Mol Surg Res Ctr, Houston, TX 77030 USA.
C3 Baylor College of Medicine
RP Dept Surg, 1 Baylor Plaza,NAB-2010, Houston, TX 77030 USA.
EM jehen@bcm.tmc.edu
RI Chai, Hong/H-5438-2011
FU NHLBI NIH HHS [R01 HL65916, K08 HL076345, R01 HL61943, R01 HL75824, R01
   HL72716] Funding Source: Medline; NIAID NIH HHS [R21 AI49116] Funding
   Source: Medline
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TC 136
Z9 152
U1 0
U2 12
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0022-4804
EI 1095-8673
J9 J SURG RES
JI J. Surg. Res.
PD JUN 1
PY 2005
VL 126
IS 1
BP 121
EP 129
DI 10.1016/j.jss.2004.12.023
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 933AR
UT WOS:000229596700019
PM 15916985
DA 2025-06-11
ER

PT J
AU Jabri, MA
   Hajaji, S
   Omrani, A
   Ben Youssef, M
   Sebai, H
AF Jabri, Mohamed-Amine
   Hajaji, Soumaya
   Omrani, Ameni
   Ben Youssef, Meriam
   Sebai, Hichem
TI Myrtle Berries Seeds Prevent Dyslipidemia, Inflammation, and Excessive
   Cardiac Reactive Oxygen Species Production in Response to High-Fat
   Diet-Induced Obesity
SO JOURNAL OF MEDICINAL FOOD
LA English
DT Article
DE anti-obesity effects; cytokines; lipid profile; lipoperoxidation; WBCs
ID METABOLIC SYNDROME; OXIDATIVE STRESS; ESSENTIAL OILS; IN-VITRO; EXTRACT;
   PROTEIN; ACID; PATHOPHYSIOLOGY; PHYTOCHEMICALS; LIPOTOXICITY
AB Anthocyanins are the major polyphenols in myrtle berries seeds aqueous extract (MBSAE). This study investigates the protective potentials of MBSAE against obesity lipotoxicity and inflammation induced by a high-fat diet (HFD). It also describes the underlying mechanisms involved in its protective effects, with special attention to myocardial reactive oxygen species (ROS) production. Male Wistar rats were fed HFD for 6 weeks to induce obesity. MBSAE (100 mg/kg, b.w., p.o.) was orally administered to HFD-fed rats. Anti-obesity effects were triggered by the inhibitory action of the MBSAE against the weights of the body, its relative heart and the total abdominal fat. Treatment with MBSAE also restored the lipid profile to baseline compared with the HFD rats and lowered also the white blood cells count, including neutrophils, lymphocytes, and basophils number as well as cytokines (tumor necrosis factor-& alpha;, interleukin [IL]-6, and IL-1 & beta;) levels in the rats serum, thus improving the tissue inflammatory status associated with obesity. Exposure of rats to HFD during 6 weeks induces a myocardial oxidative stress as assessed by deleterious effects on lipoperoxidation state, antioxidant enzyme (SOD, CAT, and GPx) activities as well as sulfhydryl groups and GSH rates. Of importance, our study shows also that HFD provokes a heart ROS (H2O2, OH & BULL;, and O-2(& BULL;-)) overload. Of interest, all these oxidative heart disturbances were clearly ended by MBSAE treatment. Therefore, consumption of MBSAE as a natural extract may be a potential therapeutic strategy to treat obesity-associated diseases.
C1 [Jabri, Mohamed-Amine; Hajaji, Soumaya; Omrani, Ameni; Ben Youssef, Meriam; Sebai, Hichem] Univ Jendouba, Higher Inst Biotechnol Beja, Unit Funct Physiol & Valorizat Bioresources, BP 382, Beja 9000, Tunisia.
C3 Universite de Jendouba
RP Jabri, MA (corresponding author), Univ Jendouba, Higher Inst Biotechnol Beja, Unit Funct Physiol & Valorizat Bioresources, BP 382, Beja 9000, Tunisia.
EM jabri.amino@gmail.com
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NR 73
TC 0
Z9 0
U1 1
U2 2
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1096-620X
EI 1557-7600
J9 J MED FOOD
JI J. Med. Food
PD SEP 1
PY 2023
VL 26
IS 9
BP 631
EP 640
DI 10.1089/jmf.2021.0199
EA AUG 2023
PG 10
WC Chemistry, Medicinal; Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Food Science & Technology; Nutrition &
   Dietetics
GA R8XE3
UT WOS:001046192700002
PM 37566463
DA 2025-06-11
ER

PT J
AU DiNatale, JC
   Crowe-White, KM
AF DiNatale, J. C.
   Crowe-White, K. M.
TI Effects of resveratrol supplementation on nitric oxide-mediated vascular
   outcomes in hypertension: A systematic review
SO NITRIC OXIDE-BIOLOGY AND CHEMISTRY
LA English
DT Review
DE Endothelial dysfunction; Blood pressure; Hypertension; Resveratrol;
   Nitric oxide; Endothelial nitric oxide synthase
ID IMPROVES CARDIOVASCULAR FUNCTION; HIGH BLOOD-PRESSURE; INSULIN
   SENSITIVITY; METABOLIC SYNDROME; OXIDATIVE STRESS; ENDOTHELIUM; RATS;
   HYPERTROPHY; SYNTHASE; ARTERY
AB Hypertension is associated with endothelial dysfunction and decreased nitric oxide (NO). It has been proposed that decreasing oxidative stress may help regulate blood pressure by increasing NO concentration. Therefore, the purpose of this systematic review was to determine whether the antioxidant resveratrol effects NO-mediated vascular outcomes in hypertension. A comprehensive literature search of PubMed and EBSCOhost databases was conducted using the terms: "resveratrol" and "nitric oxide or NO" and "hypertension or high blood pressure." Searches were not restricted for year of publication or study design but limited to full-text studies from scholarly, peer-reviewed journals. Ten animal studies published between 2005 and 2017 were identified. Human studies did not meet criteria and were not included. Articles were critically assessed using the Academy of Nutrition and Dietetics' Evidence Analysis Library Quality Criteria Worksheet. All studies evaluated resveratrol supplemen-tation and at least one NO outcome measure including: circulating NO metabolites, endothelial nitric oxide synthase (eNOS) expression, eNOS phosphorylation, and eNOS uncoupling. All but one study assessed blood pressure. Nine of ten studies reported positive significant results of resveratrol supplementation on NO outcomes, and in all but one study, this was seen concomitantly with decreases in blood pressure. Resveratrol supple-mentation shows promise for improving NO-mediated vascular outcomes and improving blood pressure. Translation to human studies is warranted, with dose of resveratrol considered, as the human equivalency doses are not consistent amongst animal studies. Additionally, a standard battery of tests examining NO-mediated vascular outcomes is needed to ensure generalizability among studies to determine dose-duration effects.
C1 [DiNatale, J. C.; Crowe-White, K. M.] Univ Alabama, Dept Human Nutr, Russell Hall,Box 870311, Tuscaloosa, AL 35401 USA.
C3 University of Alabama System; University of Alabama Tuscaloosa
RP Crowe-White, KM (corresponding author), Univ Alabama, Dept Human Nutr, Russell Hall,Box 870311, Tuscaloosa, AL 35401 USA.
EM jcdinatale@crimson.ua.edu; kcrowe@ches.ua.edu
OI Crowe-White, Kristi/0000-0003-2497-4582; DiNatale,
   Janie/0000-0002-1859-3946
CR [Anonymous], 2013, Journal of the Academy of Nutrition and Dietetics
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NR 43
TC 13
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U1 1
U2 5
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 1089-8603
EI 1089-8611
J9 NITRIC OXIDE-BIOL CH
JI Nitric Oxide-Biol. Chem.
PD DEC 1
PY 2022
VL 129
BP 74
EP 81
DI 10.1016/j.niox.2022.10.005
EA NOV 2022
PG 8
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA 6S5SA
UT WOS:000893045400002
PM 36341766
DA 2025-06-11
ER

PT J
AU Das, D
   Banerjee, A
   Jena, AB
   Duttaroy, AK
   Pathak, S
AF Das, Diptimayee
   Banerjee, Antara
   Jena, Atala Bihari
   Duttaroy, Asim K.
   Pathak, Surajit
TI Essentiality, relevance, and efficacy of adjuvant/combinational therapy
   in the management of thyroid dysfunctions
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Article
DE Thyroid dysfunction; Adjuvant therapy; Hypothyroidism; Hyperthyroidism;
   Radioiodine therapy
ID THYROTROPIN-RELEASING-HORMONE; OXIDATIVE STRESS PARAMETERS;
   CORONARY-HEART-DISEASE; GRAVES-DISEASE; METABOLIC SYNDROME; ANTIOXIDANT
   STATUS; BRAIN-DEVELOPMENT; AUTOIMMUNE-DISEASE; LIPID-PEROXIDATION;
   MOLECULAR-BASIS
AB Thyroid dysfunction is the most prevalent endocrine disorder worldwide having an epidemiology of 11% in Indians, 4.6% in the United Kingdom, and 2% in the United States of America among the overall population. The common thyroid disorders include hypothyroidism, hyperthyroidism, Hashimoto's thyroiditis, and thyroid cancer. This review briefly elaborates the molecular regulation and mechanism of thyroid hormone, and its associated thyroid disorders. The thyroid hormones regulate critical biochemical functions in brain development and function. Hypothyroidism is mainly associated with dysregulation of cytokines, increased ROS production, and altered signal transduction in major regions of the brain. In addition, it is associated with reduced antioxidant capacity and increased oxidative stress in humans. Though 70% of thyroid disorders are caused by heredity, environmental factors have a significant influence in developing autoimmune thyroid disorders in people who are predisposed to them. This drives us to understand the relationship between environmental factors and thyroid dysregulated disorders. The treatment option for the thyroid disorder includes antithyroid medications, receiving radioactive iodine therapy, or surgery at a critical stage. However, antithyroid drugs are not typically used long-term in thyroid disease due to the high recurrence rate. Adjuvant treatment of antioxidants can produce better outcomes with anti-thyroid drug treatment. Thus, Adjuvant therapy has been proven as an effective strategy for managing thyroid dysfunction, herbal remedies can be used to treat thyroid dysfunction in the future, which in turn can reduce the prevalence of thyroid disorders.
C1 [Das, Diptimayee] Chettinad Hosp & Res Inst, Chettinad Acad Res & Educ, Fac Allied Hlth Sci, Chennai 603103, Tamil Nadu, India.
   [Banerjee, Antara; Pathak, Surajit] Chettinad Hosp & Res Inst, Chettinad Acad Res & Educ, Dept Med Biotechnol, Fac Allied Hlth Sci, Chennai 603103, Tamil Nadu, India.
   [Jena, Atala Bihari] Utkal Univ, Dept Biotechnol, Bhubaneswar, Odisha, India.
   [Duttaroy, Asim K.] Univ Oslo, Inst Med Sci, Dept Nutr, Fac Med, Oslo, Norway.
C3 Utkal University; University of Oslo
RP Pathak, S (corresponding author), Chettinad Hosp & Res Inst, Chettinad Acad Res & Educ, Dept Med Biotechnol, Fac Allied Hlth Sci, Chennai 603103, Tamil Nadu, India.; Duttaroy, AK (corresponding author), Univ Oslo, Inst Med Sci, Dept Nutr, Fac Med, Oslo, Norway.
EM a.k.duttaroy@medisin.uio.no; surajit.pathak@gmail.com
RI Pathak, Surajit/AAH-4022-2020; Banerjee, Antara/AAH-4044-2020; Das,
   Diptimayee/LUY-3352-2024; Duttaroy, Asim/J-9499-2016; Jena,
   Atala/AAD-6560-2021
OI Jena, Atala Bihari/0000-0002-1690-7913
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NR 209
TC 12
Z9 12
U1 0
U2 9
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD FEB
PY 2022
VL 146
AR 112613
DI 10.1016/j.biopha.2022.112613
EA JAN 2022
PG 17
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA ZI5RX
UT WOS:000761679400004
PM 35062076
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Aragonès, G
   Dasuri, K
   Olukorede, O
   Francisco, SG
   Renneburg, C
   Kumsta, C
   Hansen, M
   Kageyama, S
   Komatsu, M
   Rowan, S
   Volkin, J
   Workman, M
   Yang, WX
   Daza, P
   Ruano, D
   Dominguez-Martín, H
   Rodríguez-Navarro, JA
   Du, XL
   Brownlee, MA
   Bejarano, E
   Taylor, A
AF Aragones, Gemma
   Dasuri, Kalavathi
   Olukorede, Opeoluwa
   Francisco, Sarah G.
   Renneburg, Carol
   Kumsta, Caroline
   Hansen, Malene
   Kageyama, Shun
   Komatsu, Masaaki
   Rowan, Sheldon
   Volkin, Jonathan
   Workman, Michael
   Yang, Wenxin
   Daza, Paula
   Ruano, Diego
   Dominguez-Martin, Helena
   Antonio Rodriguez-Navarro, Jose
   Du, Xue-Liang
   Brownlee, Michael A.
   Bejarano, Eloy
   Taylor, Allen
TI Autophagic receptor p62 protects against glycation-derived toxicity and
   enhances viability
SO AGING CELL
LA English
DT Article
DE aging; autophagy; glycative stress; p62; proteotoxicity
ID END-PRODUCTS; LIFE-SPAN; PHOSPHORYLATION; DEGRADATION; CONNEXINS;
   CROSSTALK; INTERPLAY; DISEASES; STRESS; SYSTEM
AB Diabetes and metabolic syndrome are associated with the typical American high glycemia diet and result in accumulation of high levels of advanced glycation end products (AGEs), particularly upon aging. AGEs form when sugars or their metabolites react with proteins. Associated with a myriad of age-related diseases, AGEs accumulate in many tissues and are cytotoxic. To date, efforts to limit glycation pharmacologically have failed in human trials. Thus, it is crucial to identify systems that remove AGEs, but such research is scanty. Here, we determined if and how AGEs might be cleared by autophagy. Our in vivo mouse and C. elegans models, in which we altered proteolysis or glycative burden, as well as experiments in five types of cells, revealed more than six criteria indicating that p62-dependent autophagy is a conserved pathway that plays a critical role in the removal of AGEs. Activation of autophagic removal of AGEs requires p62, and blocking this pathway results in accumulation of AGEs and compromised viability. Deficiency of p62 accelerates accumulation of AGEs in soluble and insoluble fractions. p62 itself is subject to glycative inactivation and accumulates as high mass species. Accumulation of p62 in retinal pigment epithelium is reversed by switching to a lower glycemia diet. Since diminution of glycative damage is associated with reduced risk for age-related diseases, including age-related macular degeneration, cardiovascular disease, diabetes, Alzheimer's, and Parkinson's, discovery of methods to limit AGEs or enhance p62-dependent autophagy offers novel potential therapeutic targets to treat AGEs-related pathologies.
C1 [Aragones, Gemma; Dasuri, Kalavathi; Olukorede, Opeoluwa; Francisco, Sarah G.; Renneburg, Carol; Rowan, Sheldon; Volkin, Jonathan; Workman, Michael; Yang, Wenxin; Bejarano, Eloy; Taylor, Allen] Tufts Univ, USDA Human Nutr Res Ctr Aging, Lab Nutr & Vis Res, Boston, MA 02111 USA.
   [Kumsta, Caroline; Hansen, Malene] Sanford Burnham Prebys Med Discovery Inst, La Jolla, CA USA.
   [Kageyama, Shun; Komatsu, Masaaki] Juntendo Univ, Dept Physiol, Sch Med, Bunkyo Ku, Tokyo, Japan.
   [Daza, Paula] Univ Seville, Fac Biol, Dept Biol Celular, Seville, Spain.
   [Ruano, Diego; Dominguez-Martin, Helena] Univ Seville, Fac Farm, Dept Bioquim & Biol Mol, Seville, Spain.
   [Ruano, Diego; Dominguez-Martin, Helena] Univ Seville, CSIC, Hosp Univ Virgen del Rocio, Inst Biomed Sevilla IBIS, Seville, Spain.
   [Antonio Rodriguez-Navarro, Jose] Hosp Ramon & Cajal, Inst Ramon y Cajal Invest Sanitarias, Serv Neurobiol, Dept Invest, Carretera Colmenar, Madrid, Spain.
   [Du, Xue-Liang; Brownlee, Michael A.] Albert Einstein Coll Med, Bronx, NY 10467 USA.
   [Bejarano, Eloy] Univ CEU Cardenal Herrera, Sch Hlth Sci, Valencia, Spain.
C3 Tufts University; United States Department of Agriculture (USDA);
   Sanford Burnham Prebys Medical Discovery Institute; Juntendo University;
   University of Sevilla; University of Sevilla; Virgen del Rocio
   University Hospital; Consejo Superior de Investigaciones Cientificas
   (CSIC); University of Sevilla; CSIC-JA-USE - Instituto de Biomedicina de
   Sevilla (IBIS); Hospital Universitario Ramon y Cajal; Montefiore Medical
   Center; Albert Einstein College of Medicine; Yeshiva University;
   Universidad CEU Cardenal Herrera
RP Bejarano, E; Taylor, A (corresponding author), Tufts Univ, USDA Human Nutr Res Ctr Aging, Lab Nutr & Vis Res, Boston, MA 02111 USA.
EM eloy.bejarano@tufts.edu; allen.taylor@tufts.edu
RI Daza-Navarro, Paula/U-4540-2018; DASURI, KALAVATHI/E-7381-2012; Kumsta,
   Caroline/AAU-9147-2020; Bejarano, Eloy/AAJ-4708-2021; Ruano,
   Diego/IQU-0145-2023; Komatsu, Masaaki/B-8321-2011; Yang,
   Wenxin/KFB-7092-2024; RUANO, DIEGO/I-4471-2014; Aragones,
   Gemma/A-9693-2013
OI RUANO, DIEGO/0000-0001-6131-3033; Francisco, Sarah/0000-0001-9794-1533;
   Bejarano Fernandez, Eloy/0000-0001-8390-1581; Aragones,
   Gemma/0000-0002-1924-9231; Yang, Wenxin/0009-0006-9141-367X
FU NIH [R01AG028664, R21AG058038, R01EY021212, R01EY026979, R01EY028559];
   Thome Memorial Foundation; USDA [8050-51000-089-01S]; BrightFocus
   Foundation; Human Nutrition Research Center on Aging; USDA NIFA
   [2016-08885]; MINECO SAF [2016 78666-R]; Grants-in-Aid for Scientific
   Research [20K06549] Funding Source: KAKEN
FX NIH, Grant/Award Number: R01AG028664, R21AG058038, R01EY021212,
   R01EY026979 and R01EY028559; Thome Memorial Foundation; USDA,
   Grant/Award Number: 8050-51000-089-01S; BrightFocus Foundation; Human
   Nutrition Research Center on Aging; USDA NIFA, Grant/Award Number:
   2016-08885; MINECO SAF, Grant/Award Number: 2016 78666-R
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NR 46
TC 32
Z9 32
U1 2
U2 21
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1474-9718
EI 1474-9726
J9 AGING CELL
JI Aging Cell
PD NOV
PY 2020
VL 19
IS 11
AR e13257
DI 10.1111/acel.13257
EA NOV 2020
PG 17
WC Cell Biology; Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Geriatrics & Gerontology
GA PA5EA
UT WOS:000584687700001
PM 33146912
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Bekyarova, G
   Tzaneva, M
   Bratoeva, K
   Kotzev, I
   Radanova, M
AF Bekyarova, Ganka
   Tzaneva, Maria
   Bratoeva, Kamelia
   Kotzev, Iscren
   Radanova, Maria
TI HEME-OXYGENASE-1 UPREGULATED BY S-ADENOSYLMETHIONINE. POTENTIAL
   PROTECTION AGAINST NON-ALCOHOLIC FATTY LIVER INDUCED BY HIGH FRUCTOSE
   DIET
SO FARMACIA
LA English
DT Article
DE high fructose diet; non-alcoholic fatty liver; heme-oxygenase-1;
   S-adenosylmethionine
ID ADENOSYL-L-METHIONINE; HEME OXYGENASE-1; OXIDATIVE STRESS;
   INSULIN-RESISTANCE; CARBON-MONOXIDE; DISEASE; PATHOGENESIS;
   STEATOHEPATITIS; CONSUMPTION; TOCOPHEROL
AB Excessive dietary fructose intake may have an important role in the current epidemics of fatty liver disease, obesity and diabetes-features of metabolic syndrome. We evaluated the relationship between lipid peroxidation and other oxidative stress biomarkers with changes in expression of heme oxygenase-1 (HO-1) in rat fatty liver, induced by high fructose diet (HFD) and the effect of S-adenosylmethionine (SAMe). Twenty-one male rats were randomly assigned to three groups of seven animals each: HFD (35% fructose in drinking water for 16 weeks) group, HFD + SAMe (20 mg/kg b.w. in drinking water for 16 weeks) group and control group. HO-1 expression, malonyl dialdehyde (MDA) (a marker of lipid peroxidation), triglycerides (TG), SH group levels and histological studies were performed on hepatic tissue. HFD group showed microvesicular steatosis without inflammation and fibrosis. In HFD+SAM group microvesicular steatosis was not established. The HO-1 expression was significantly increased in HFD rats. SEMe augmented the increase in expression of HO-1. The levels of MDA and TG were elevated in HFD group. In HFD rats with lower levels of SH exhibited higher expression of HO-1. SAMe inhibited the increase in lipid peroxidation and TG levels and prevented the decrease in SH levels. In conclusion, SAMe has an important hepatoprotective effect and its protection is most probably exerted by increasing the expression of the antioxidant enzyme HO-1, in order to prevent the development of fatty liver.
C1 [Bekyarova, Ganka; Bratoeva, Kamelia] Med Univ Varna, Dept Physiol & Pathophysiol, Varna, Bulgaria.
   [Tzaneva, Maria] Med Univ Varna, Dept Gen & Clin Pathol, Varna, Bulgaria.
   [Kotzev, Iscren] Med Univ Varna, Clin Gastroenterol MHAT ST Marina, Varna, Bulgaria.
   [Radanova, Maria] Med Univ Varna, Dept Biochem Mol Med & Nutrigen, Varna, Bulgaria.
C3 Medical University Varna; Medical University Varna; Medical University
   Varna; Medical University Varna
RP Bekyarova, G (corresponding author), Med Univ Varna, Dept Physiol & Pathophysiol, Varna, Bulgaria.
EM gabekyarova2001@yahoo.com
RI Radanova, Maria/A-7081-2015
OI Radanova, Maria/0000-0002-0941-6139
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NR 42
TC 7
Z9 7
U1 0
U2 5
PU SOC STIINTE FARMACEUTICE ROMANIA
PI BUCURESTI
PA BUCURESTI, STR TRAIAN VUIA 6, SECT 1, BUCURESTI, 020956, ROMANIA
SN 0014-8237
EI 2065-0019
J9 FARMACIA
JI Farmacia
PD MAR-APR
PY 2017
VL 65
IS 2
BP 262
EP 267
PG 6
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA ET2TK
UT WOS:000400126800017
DA 2025-06-11
ER

PT J
AU Zhang, Y
   Zhang, L
   Zhang, Y
   Xu, JJ
   Sun, LL
   Li, SZ
AF Zhang, Yuan
   Zhang, Lei
   Zhang, Yi
   Xu, Jin-Jin
   Sun, Li-Li
   Li, Shuang-Zhan
TI The protective role of liquiritin in high fructose-induced myocardial
   fibrosis via inhibiting NF-κB and MAPK signaling pathway
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Article
DE Myocardial fibrosis; Liquiritin; Inflammation; NF-kappa B; MAPKs
ID METABOLIC SYNDROME; INSULIN-RESISTANCE; OXIDATIVE STRESS;
   18-BETA-GLYCYRRHETINIC ACID; CARDIOVASCULAR-DISEASE;
   GLYCYRRHIZA-URALENSIS; PI3K/AKT PATHWAY; CANCER-CELLS; KINASE;
   INFLAMMATION
AB Diabetic cardiomyopathy has been known as an important complication of diabetes and characterized by persistent diastolic dysfunction, resulting in myocardial fibrosis, which is associated inflammatory response and oxidative stress. Liquiritin is a major constituent of Glycyrrhiza Radix, possessing various pharmacological activities and exhibiting various positive biological effects, including anti-cancer, anti-oxidative and neuroprotective effects. Here, we investigated the anti-inflammatory properties and protective effects of lquiritin in high fructose-induced mice and cardiomyocytes to clarify the potential mechanism. The mice were divided into the control mice, 30% high fructose-induced mice, 10 mg/kg liquiritin-treaed mice after fructose feeding and 20 mg/kg liquiritin-treaed mice after fructose feeding. Liquiritin effectively reduced the lipid accumulation and insulin resistance induced by fructose feeding. In comparison to high fructose-feeding control mice, liquiritin-treated mice developed less myocardial fibrosis with lower expression of Collagen type I, Collagen type II and alpha smooth muscle-actin (alpha-SMA). In addition, liquiritin significantly reduced the inflammatory cytokine release and NF-kappa B phosphorylation through IKK alpha/IkB alpha signaling pathway suppression. Further, Mitogen-activated protein kinases (MAPKs), including p38, ERK1/2 and JNK, was up-regulated for fructose stimulation, which was inactivated by liquiritin treatment in vivo and in vitro studies. Our data indicates that liquiritin has a protective effect against high fructose-induced myocardial fibrosis via suppression of NF-kB and MAPKs signaling pathways, and liquiritin may be a promising candidate for diabetes-related myocardial fibrosis treatment. (C) 2016 Published by Elsevier Masson SAS.
C1 [Zhang, Yuan; Zhang, Lei; Xu, Jin-Jin; Sun, Li-Li; Li, Shuang-Zhan] Henan Univ, Huaihe Hosp, Dept Cardiol, Kaifeng 475000, Peoples R China.
   [Zhang, Yi] Fifth Peoples Hosp Shenzhen City, Dept Cardiol, Shenzhen 518001, Peoples R China.
C3 Henan University
RP Zhang, Y (corresponding author), Henan Univ, Huaihe Hosp, Dept Cardiol, Kaifeng 475000, Peoples R China.
EM zhangyuan475000@163.com
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NR 48
TC 74
Z9 94
U1 1
U2 46
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD DEC
PY 2016
VL 84
BP 1337
EP 1349
DI 10.1016/j.biopha.2016.10.036
PG 13
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA EF6JU
UT WOS:000390438100156
PM 27810791
DA 2025-06-11
ER

PT J
AU Cunningham, J
AF Cunningham, Joan
TI Socio-economic gradients in self-reported diabetes for Indigenous and
   non-Indigenous Australians aged 18-64
SO AUSTRALIAN AND NEW ZEALAND JOURNAL OF PUBLIC HEALTH
LA English
DT Article
DE Indigenous Australian; diabetes; socio-economic status; health
   disparities
ID METABOLIC SYNDROME; NATIONAL-HEALTH; RISK-FACTORS; PREVALENCE; MELLITUS;
   OBESITY; DISEASES; GLUCOSE; STRESS; INDIA
AB Objective: To examine and compare socio-economic gradients in diabetes among Indigenous and non-Indigenous Australians.
   Methods: I analysed weighted data on self-reported diabetes and a range of socio-economic status (SES) measures for 5,417 Indigenous and 15,432 non-Indigenous adults aged 18-64 years from two nationally representative surveys conducted in parallel by the Australian Bureau of Statistics in 2004-05.
   Results: After adjusting for age, diabetes prevalence was significantly higher among those of lower SES in both Indigenous and non-Indigenous populations. The age- and sex-adjusted odds ratios (OR) for diabetes for the lowest versus the highest SES group were similar for the two populations on many variables. For example, the OR for the lowest quintile of equivalised household income (compared with quintiles 3-5 combined) was 2.3 (95% CI 1.6-3.4) for the Indigenous population and 2.0 (95% CI 1.5-2.8) for the non-Indigenous population. However, Indigenous people of high SES had greater diabetes prevalence than low SES non-Indigenous people on every SES measure examined.
   Conclusion: Socio-economic status explains some but not all of the difference in diabetes prevalence between Indigenous and non-Indigenous Australians. Other factors that may operate across the socio-economic spectrum, such as racism, stress, loss and grief, may also be relevant and warrant further examination.
   Implications: Indigenous Australians do not constitute a homogeneous group with respect to socio-economic status or diabetes prevalence, and this diversity must be recognised in developing measures to redress Indigenous health disadvantage.
C1 [Cunningham, Joan] Charles Darwin Univ, Menzies Sch Hlth Res, Casuarina, NT 0811, Australia.
   [Cunningham, Joan] Charles Darwin Univ, Inst Adv Studies, Casuarina, NT 0811, Australia.
C3 Charles Darwin University; Menzies School of Health Research; Charles
   Darwin University
RP Cunningham, J (corresponding author), Charles Darwin Univ, Menzies Sch Hlth Res, POB 41096, Casuarina, NT 0811, Australia.
EM joan.cunningham@menzies.edu.au
RI Cunningham, Joan/E-6339-2012
FU Remote Area Data Laboratory; National Health and Medical Research
   Council [545200]
FX I gratefully acknowledge the staff of the Australian Bureau of
   Statistics for a range of contributions, including the design and
   implementation of the NATSIHS and NHS, and the development and support
   of the Remote Area Data Laboratory. I also thank all NATSIHS and NHS
   participants; this study would not have been possible without them. This
   work was supported by a National Health and Medical Research Council
   Research Fellowship (#545200).
CR [Anonymous], HLTH MINORITY ETHNIC
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NR 42
TC 20
Z9 20
U1 0
U2 11
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1326-0200
J9 AUST NZ J PUBL HEAL
JI Aust. N. Z. Publ. Health
PD JUL
PY 2010
VL 34
SU 1
BP S18
EP S24
DI 10.1111/j.1753-6405.2010.00547.x
PG 7
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA 623EN
UT WOS:000279721000005
PM 20618286
DA 2025-06-11
ER

PT J
AU Pachikian, BD
   Neyrinck, AM
   Deldicque, L
   De Backer, FC
   Catry, E
   Dewulf, EM
   Sohet, FM
   Bindels, LB
   Everard, A
   Francaux, M
   Guiot, Y
   Cani, PD
   Delzenne, NM
AF Pachikian, Barbara D.
   Neyrinck, Audrey M.
   Deldicque, Louise
   De Backer, Fabienne C.
   Catry, Emilie
   Dewulf, Evelyne M.
   Sohet, Florence M.
   Bindels, Laure B.
   Everard, Amandine
   Francaux, Marc
   Guiot, Yves
   Cani, Patrice D.
   Delzenne, Nathalie M.
TI Changes in Intestinal Bifidobacteria Levels Are Associated with the
   Inflammatory Response in Magnesium-Deficient Mice
SO JOURNAL OF NUTRITION
LA English
DT Article
ID HIGH-FAT-DIET; GLUCAGON-LIKE PEPTIDE-2; SERUM HDL-CHOLESTEROL; METABOLIC
   SYNDROME; BARRIER FUNCTION; GUT MICROBIOTA; INSULIN-RESISTANCE; STRESS;
   RATS; ENDOTOXEMIA
AB Magnesium (Mg) deficiency is a common nutritional disorder that is linked to an inflammatory state characterized by increased plasma acute phase protein and proinflammatory cytokine concentrations. Recent studies have shown that changes in the composition of gut microbiota composition participate in systemic inflammation. In this study, therefore, we assessed the potential role of gut microbiota in intestinal and systemic inflammation associated with Mg deficiency in mice. For this purpose, mice were fed a control or Mg-deficient diet (500 mg vs. 70 mg Mg/kg) for 4 or 21 d. Compared with the mice fed the control diet, mice fed the Mg-deficient diet for 4 d had a lower gut bifidobacteria content (-1.5 log), a 36-50% lower mRNA content of factors controlling gut barrier function in the ileum (zonula occludens-1, occludin, proglucagon), and a higher mRNA content (by similar to 2-fold) in the liver and/or intestine of tumor necrosis factor-alpha, interleukin-6, CCAAT/enhancer binding protein homologous protein, and activating transcription factor 4, reflecting inflammatory and cellular stress. In contrast, mice fed the Mg-deficient diet for 21 d had a higher cecal bifidobacteria content compared with the control group, a phenomenon accompanied by restoration of the intestinal barrier and the absence of inflammation. In conclusion, we show that Mg deficiency, independently of any other changes in nutrient intake, modulates the concentration of bifidobacteria in the gut, a phenomenon that may time-dependently affect inflammation and metabolic disorders in mice. J. Nutr. 140: 509-514, 2010.
C1 [Pachikian, Barbara D.; Neyrinck, Audrey M.; De Backer, Fabienne C.; Catry, Emilie; Dewulf, Evelyne M.; Sohet, Florence M.; Bindels, Laure B.; Everard, Amandine; Cani, Patrice D.; Delzenne, Nathalie M.] Univ Catholique Louvain, Louvain Drug Res Inst, Metab & Nutr Res Grp, B-1200 Brussels, Belgium.
   [Guiot, Yves] Univ Catholique Louvain, Dept Pathol, B-1200 Brussels, Belgium.
   [Deldicque, Louise; Francaux, Marc] Univ Catholique Louvain, Inst Neurosci, Res Grp Muscle & Exercise Physiol, B-1348 Louvain, Belgium.
C3 Universite Catholique Louvain; Universite Catholique Louvain; Cliniques
   Universitaires Saint-Luc; Universite Catholique Louvain
RP Delzenne, NM (corresponding author), Univ Catholique Louvain, Louvain Drug Res Inst, Metab & Nutr Res Grp, B-1200 Brussels, Belgium.
EM nathalie.delzenne@uclouvain.be
RI Neyrinck, Audrey/AAE-7929-2019; Delzenne, Nathalie/AAC-4628-2019;
   Bindels, Laure/T-7846-2019; Francaux, Marc/C-5594-2008; Cani, Patrice
   D./M-8055-2016
OI Everard, Amandine/0000-0001-8925-8144; Francaux,
   Marc/0000-0001-8182-1588; Bindels, Laure B./0000-0003-3747-3234;
   Deldicque, Louise/0000-0003-3393-5278; Delzenne,
   Nathalie/0000-0003-2115-6082; Neyrinck, Audrey/0000-0002-9435-3338;
   Cani, Patrice D./0000-0003-2040-2448
FU Fonds National de la Recherche Scientifique [FRSM 3.4574.07]; Region
   Wallonne [Walnut 20]
FX Supported by the Fonds National de la Recherche Scientifique (convention
   FRSM 3.4574.07) and by the Region Wallonne (Walnut 20).
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NR 40
TC 87
Z9 92
U1 0
U2 15
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0022-3166
EI 1541-6100
J9 J NUTR
JI J. Nutr.
PD MAR
PY 2010
VL 140
IS 3
BP 509
EP 514
DI 10.3945/jn.109.117374
PG 6
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 559FJ
UT WOS:000274807800011
PM 20089787
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Khan, M
   Gul, S
   Rehman, I
   Leghari, QA
   Badar, R
   Zille-Huma
AF Khan, Maria
   Gul, Somia
   Rehman, Iqra
   Leghari, Qurratul-ain
   Badar, Rabia
   Zille-Huma
TI Protective effect of lycopene against celecoxib induced fat deposition
   and glycogen reduction in liver cells
SO JOURNAL OF TAIBAH UNIVERSITY MEDICAL SCIENCES
LA English
DT Article
DE Celecoxib; Docking studies; Fatty degeneration; Glycogen depletion;
   Lycopene; Natural product
ID PHARMACOKINETICS; RATS
AB Objective: Oxidative stress develops because of a shift in the prooxidant-antioxidant balance toward the former, because of disturbances in redox signaling and control. Celecoxib (Cb), a selective COX-2 inhibitor, is a drug that effectively decreases pain and inflammation. However, Cb causes oxidative injury to hepatic tissues via enhanced lipid peroxidation, thus resulting in excessive production of reactive oxygen species. Consequently, frequent or long-term Cb use may lead to hepatic, renal, and other noticeable adverse effects. Lycopene (lyco), a potent antioxidant naturally occurring in pigmented fruits and vegetables, actively eradicates singlet oxygen and other free radicals, thereby protecting cells against destruction of the plasma membrane by free radicals. Methods: We hypothesized that lyco might protect rat liver cells against Cb-induced oxidative stress, thus reducing fatty infiltration and glycogen depletion. Rats were randomized into three groups (with ten rats each) receiving control (group A, saline only), Cb (group B, 50 mg/kg, orally), or Cb + lyco (group C, 50 mg/kg, orally) for 30 days. Subsequently, liver tissues were examined, and the average liver weight and histological changes in fat and glycogen content were determined. Results: Lyco mitigated hepatocyte damage in Cbtreated rats, reducing fat accumulation and glycogen loss, probably through its antioxidant properties. Concomitant lyco and Cb intake prevented hepatotoxic adverse effects due to oxidative injury, as well as nonalcoholic fatty liver disease (NAFLD), a key component of metabolic syndrome. Moreover, the binding orientation of lyco in the binding site of COX-2 enzyme revealed that the docked complex had noteworthy binding strength. Conclusion: In conclusion, our study revealed lyco's protective effects against Cb-induced hepatic damage by reducing fat and glycogen depletion.
C1 [Khan, Maria] Dow Univ Hlth Sci, Dr Ishrat Ul Ebad Khan Inst Oral Hlth Sci, Dept Anat, Karachi, Pakistan.
   [Gul, Somia; Rehman, Iqra] Jinnah Univ Women, Fac Pharm, Dept Pharmaceut Chem, Karachi 74600, Pakistan.
   [Leghari, Qurratul-ain] Hamdard Univ, Fac Pharm, Dept Pharmaceut Chem, Karachi, Pakistan.
   [Badar, Rabia] Jinnah Univ Women, Fac Sci, Dept Bot, Karachi, Pakistan.
   [Zille-Huma] Dow Univ Hlth Sci, Dept Med, Karachi, Pakistan.
C3 Dow University of Health Sciences; Fatima Jinnah Women University
   (FJWU), Rawalpindi; Hamdard University; Fatima Jinnah Women University
   (FJWU), Rawalpindi; Dow University of Health Sciences
RP Gul, S (corresponding author), Jinnah Univ Women, Fac Pharm, Dept Pharmaceut Chem, Karachi 74600, Pakistan.
EM drsomi1983@yahoo.com
RI Gul, Prof. Dr. Somia/GVU-8906-2022
FX This research did not receive any specific grant from funding agencies
   in the public, commercial, or not-for-profit sectors. According to the
   Institutional Review Board Statement, all procedures in the study were
   performed in accordance with the Declaration of Helsinki, and the study
   was approved by the Jinnah Postgraduate Medical Centre (JPMC) ethical
   committee under letter No. F.1-2/BMSI-E.COMT/JPMC.
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NR 47
TC 1
Z9 1
U1 1
U2 1
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1658-3612
J9 J TAIBAH UNIV MED SC
JI J. Taibah Univ. Med. Soc.
PD AUG
PY 2024
VL 19
IS 4
BP 856
EP 866
DI 10.1016/j.jtumed.2024.07.007
EA AUG 2024
PG 11
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA D7P9G
UT WOS:001298077100001
PM 39253362
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Quetglas-Llabrés, MM
   Monserrat-Mesquida, M
   Bouzas, C
   Llompart, I
   Mateos, D
   Casares, M
   Ugarriza, L
   Martínez, JA
   Tur, JA
   Sureda, A
AF Quetglas-Llabres, Maria Magdalena
   Monserrat-Mesquida, Margalida
   Bouzas, Cristina
   Llompart, Isabel
   Mateos, David
   Casares, Miguel
   Ugarriza, Lucia
   Martinez, J. Alfredo
   Tur, Josep A.
   Sureda, Antoni
TI Mediterranean Diet Improves Plasma Biomarkers Related to Oxidative
   Stress and Inflammatory Process in Patients with Non-Alcoholic Fatty
   Liver Disease
SO ANTIOXIDANTS
LA English
DT Article
DE non-alcoholic fatty liver disease; Mediterranean diet; metabolic
   syndrome; oxidative stress; inflammation
ID INTESTINAL PERMEABILITY; INSULIN-RESISTANCE; ASSOCIATION;
   CYTOKERATIN-18; MICROBIOTA; REDUCTION; SEVERITY; STRATEGY; BENEFITS;
   OMENTIN
AB Non-alcoholic fatty liver disease (NAFLD) shows liver fat depots without alcohol consumption. NAFLD does not have specific drug therapies, with a healthy lifestyle and weight loss being the main approaches to prevent and treat NAFLD. The aim was to assess the antioxidant and pro-inflammatory state in patients with NAFLD after 12-month-lifestyle intervention depending on the change in adherence to a Mediterranean diet (AMD). Antioxidant and inflammatory biomarkers were measured in 67 adults (aged 40-60 years old) diagnosed with NAFLD. Anthropometric parameters and dietary intake were measured by a validated semi-quantitative 143-item food frequency questionnaire. The nutritional intervention improved anthropometric and biochemical parameters after a 12-month follow-up. However, decreases in alanine aminotransferase (ALT) and C reactive protein (CRP) were higher in participants with high AMD, which also showed higher improvement in physical fitness (Chester step test) and intrahepatic fat contents. The intervention reduced plasma levels of malondialdehyde, myeloperoxidase, zonulin, and omentin, and increased resolvin D1 (RvD1), whereas the decrease in leptin, ectodysplasin-A (EDA), cytokeratin-18 (CK-18), interleukin-1ra (IL-1ra) and endotoxin was only significant in participants with higher AMD. The current study showed that a one-year nutritional intervention improved main NAFLD features such as body mass index, IFC, liver enzymes, and prooxidant and proinflammatory status. There was also a decrease in the concentration of plasmatic endotoxin, suggesting an improvement in intestinal permeability. These health benefits were more evident in participants that improved AMD to a greater extent. The trial was registered at ClinicalTrials.gov with registry number NCT04442620.
C1 [Quetglas-Llabres, Maria Magdalena; Monserrat-Mesquida, Margalida; Bouzas, Cristina; Llompart, Isabel; Mateos, David; Ugarriza, Lucia; Tur, Josep A.; Sureda, Antoni] Univ Balearic Isl, Res Grp Community Nutr & Oxidat Stress, IUNICS, Palma De Mallorca 07122, Spain.
   [Quetglas-Llabres, Maria Magdalena; Monserrat-Mesquida, Margalida; Bouzas, Cristina; Llompart, Isabel; Mateos, David; Ugarriza, Lucia; Tur, Josep A.; Sureda, Antoni] Hlth Res Inst Balearic Isl IdISBa, Palma De Mallorca 07120, Spain.
   [Monserrat-Mesquida, Margalida; Bouzas, Cristina; Llompart, Isabel; Mateos, David; Martinez, J. Alfredo; Tur, Josep A.; Sureda, Antoni] Inst Salud Carlos III ISCIII, CIBER Fisiopatol Obes & Nutr CIBEROBN, Madrid 28029, Spain.
   [Casares, Miguel] Red Asistencial Juaneda, Radiodiag Serv, Palma De Mallorca 07011, Spain.
   [Ugarriza, Lucia] Univ Hosp Son Espases, Clin Anal Serv, Palma De Mallorca 07198, Spain.
   [Martinez, J. Alfredo] CEI UAM CSIC, Cardiometab Precis Nutr Program, IMDEA Food, Madrid 28049, Spain.
   [Martinez, J. Alfredo] Univ Navarra, Dept Nutr Food Sci & Physiol, Pamplona 31008, Spain.
C3 Universitat de les Illes Balears; IUNICS; Institut Investigacio
   Sanitaria Illes Balears (IdISBa); CIBER - Centro de Investigacion
   Biomedica en Red; CIBEROBN; Hospital Universitari Son Espases; IMDEA
   Food Institute; Consejo Superior de Investigaciones Cientificas (CSIC);
   University of Navarra
RP Tur, JA (corresponding author), Univ Balearic Isl, Res Grp Community Nutr & Oxidat Stress, IUNICS, Palma De Mallorca 07122, Spain.; Tur, JA (corresponding author), Hlth Res Inst Balearic Isl IdISBa, Palma De Mallorca 07120, Spain.; Tur, JA (corresponding author), Inst Salud Carlos III ISCIII, CIBER Fisiopatol Obes & Nutr CIBEROBN, Madrid 28029, Spain.
EM m.quetglas@uib.es; margalida.monserrat@uib.es; cristina.bouzas@uib.es;
   isabel.llompart@ssib.es; davidfrom13@gmail.com; casaresmiguel@gmail.com;
   luciaugarriza@gmail.com; jalfredo.martinez@imdea.org; pep.tur@uib.es;
   antoni.sureda@uib.es
RI Quetglas Llabrés, Maria/AAA-4412-2019; Mateos, David/N-7366-2018; Tur,
   Josep/AAE-5748-2020; Bouzas, Cristina/AAE-2069-2019; Sureda,
   Antoni/N-9588-2019; Mesquida, Margalida/AAB-4773-2019; Martínez,
   J./K-8709-2014; Tur, Josep/F-5576-2014
OI , Antoni/0000-0001-8656-6838; Tur, Josep/0000-0002-6940-0761; Monserrat
   Mesquida, Margalida/0000-0002-8856-135X; Bouzas Velasco,
   Cristina/0000-0002-1407-8461; Quetglas Llabres, Maria
   Magdalena/0000-0003-4155-7780
FU Fundacio~La Marato~TV3 (Spain) [201630.10]; Instituto de Salud Carlos
   III [CIBEROBN CB12/03/30038, CIBER OBN18PI03]; Health Department of the
   Government of Navarra [61/2015]; (Balearic Islands Gov.) - European
   Regional Development Fund [35/2011, 23/2012]; IDISBA pre-doctoral grant
   [JUNIOR19-05]; SOIB Program for Qualified Young People; Juan de la
   Cierva post-doc grant
FX Fundacio La Marato TV3 (Spain) project ref. 201630.10. Instituto de
   Salud Carlos III through the CIBEROBN CB12/03/30038, and Proyecto
   Intramural CIBER OBN18PI03), Health Department of the Government of
   Navarra (61/2015), and Grant of support to research groups no. 35/2011
   and 23/2012 (Balearic Islands Gov.), which are co-funded by the European
   Regional Development Fund. M.M.Q.-L. was granted by the IDISBA
   pre-doctoral grant (JUNIOR19-05). M.M.-M. was granted by SOIB Program
   for Qualified Young People. C.B. was granted by a Juan de la Cierva
   post-doc grant. The funding sponsors had no role in the design of the
   study, in the collection, analyses, or interpretation of the data; in
   the writing of the manuscript, or in the decision to publish the
   results.
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NR 67
TC 20
Z9 20
U1 2
U2 6
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD APR
PY 2023
VL 12
IS 4
AR 833
DI 10.3390/antiox12040833
PG 17
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA E9LN0
UT WOS:000978671400001
PM 37107208
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Sayed, TS
   Maayah, ZH
   Zeidan, HA
   Agouni, A
   Korashy, HM
AF Sayed, Tahseen S.
   Maayah, Zaid H.
   Zeidan, Heba A.
   Agouni, Abdelali
   Korashy, Hesham M.
TI Insight into the physiological and pathological roles of the aryl
   hydrocarbon receptor pathway in glucose homeostasis, insulin resistance,
   and diabetes development
SO CELLULAR & MOLECULAR BIOLOGY LETTERS
LA English
DT Review
DE Aryl hydrocarbon receptor; Diabetes mellitus; Glucose hemostasis;
   Insulin; Environmental toxicants
ID PERSISTENT ORGANIC POLLUTANTS; PANCREATIC BETA-CELLS; LIVER RETINOID
   ACCUMULATION; REGULATORY T-CELLS; ALPHA PPAR-ALPHA;
   POLYCHLORINATED-BIPHENYLS; METABOLIC SYNDROME; OXIDATIVE STRESS;
   GENE-EXPRESSION; AH-RECEPTOR
AB The aryl hydrocarbon receptor (AhR) is a ligand-activated transcriptional factor that mediates the toxicities of several environmental pollutants. Decades of research have been carried out to understand the role of AhR as a novel mechanism for disease development. Its involvement in the pathogenesis of cancer, cardiovascular diseases, rheumatoid arthritis, and systemic lupus erythematosus have long been known. One of the current hot research topics is investigating the role of AhR activation by environmental pollutants on glucose homeostasis and insulin secretion, and hence the pathogenesis of diabetes mellitus. To date, epidemiological studies have suggested that persistent exposure to environmental contaminants such as dioxins, with subsequent AhR activation increases the risk of specific comorbidities such as obesity and diabetes. The importance of AhR signaling in various molecular pathways highlights that the role of this receptor is far beyond just xenobiotic metabolism. The present review aims at providing significant insight into the physiological and pathological role of AhR and its regulated enzymes, such as cytochrome P450 1A1 (CYP1A1) and CYP1B1 in both types of diabetes. It also provides a comprehensive summary of the current findings of recent research studies investigating the role of the AhR/CYP1A1 pathway in insulin secretion and glucose hemostasis in the pancreas, liver, and adipose tissues. This review further highlights the molecular mechanisms involved, such as gluconeogenesis, hypoxia-inducible factor (HIF), oxidative stress, and inflammation.
C1 [Sayed, Tahseen S.; Maayah, Zaid H.; Agouni, Abdelali; Korashy, Hesham M.] Qatar Univ, Coll Pharm, Dept Pharmaceut Sci, QU Hlth, Doha 2713, Qatar.
   [Zeidan, Heba A.] Amer Sch Doha, Doha, Qatar.
C3 Qatar University
RP Korashy, HM (corresponding author), Qatar Univ, Coll Pharm, Dept Pharmaceut Sci, QU Hlth, Doha 2713, Qatar.
EM hkorashy@qu.edu.qa
RI Agouni, Abdelali/AAP-5298-2020; Korashy, Hesham/A-1059-2010
OI Agouni, Abdelali/0000-0002-8363-1582; Korashy, Hesham
   M./0000-0002-5745-9643; Maayah ( Zaid Alma'ayah), Zaid
   H./0000-0003-0276-9916
FU Qatar University Internal Grant, Doha, Qatar [IRCC-2022-484]
FX This publication was supported by Qatar University Internal Grant no.
   IRCC-2022-484, Doha, Qatar.
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NR 171
TC 28
Z9 30
U1 5
U2 25
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1425-8153
EI 1689-1392
J9 CELL MOL BIOL LETT
JI Cell. Mol. Biol. Lett.
PD DEC
PY 2022
VL 27
IS 1
AR 103
DI 10.1186/s11658-022-00397-7
PG 26
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA 6J8EH
UT WOS:000887051300003
PM 36418969
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Liu, YY
   Wang, MJ
   Xu, W
   Zhang, HM
   Qian, WH
   Li, X
   Cheng, XB
AF Liu, Yuanyuan
   Wang, Mengjie
   Xu, Wei
   Zhang, Hongman
   Qian, Weihe
   Li, Xiang
   Cheng, Xingbo
TI Active vitamin D supplementation alleviates initiation and progression
   of nonalcoholic fatty liver disease by repressing the p53 pathway
SO LIFE SCIENCES
LA English
DT Article
DE Active vitamin D; Nonalcoholic fatty liver disease; p53 pathway;
   Senescence; Apoptosis; Oxidative stress
ID OXIDATIVE STRESS; CELLS; NAFLD; SENESCENCE; EXPRESSION; STEATOSIS;
   PROTECTS; ACTIVATION; APOPTOSIS; PROMOTER
AB Background/aims: Recent studies have found vitamin D deficiency promotes fat deposition into the hepatocytes, thus contributing to the development of nonalcoholic fatty liver disease (NAFLD), which is a hepatic manifestation of metabolic syndrome. This study aimed to investigate the potential effects of vitamin D on NAFLD with the involvement of the p53 pathway.
   Methods: Initially, an in vivo high-fat diet (HFD)-induced NAFLD mouse model was established. Then the HFD-induced NAFLD mice were treated with vitamin D. Next, the serum levels of TNF-alpha, GSH-px and malondialdehyde (MDA) were assessed using ELISA and ROS content was evaluated by flow cytometry, followed by the measurement of expression of Duox1, Duox2, SOD1, SOD2, PRDX1 I, ACC, SREBP1c, MTTP, PPAR alpha, p53, p21 and p16 using RT-qPCR and Western blot analysis. Positive expression of FAS and FASL proteins was measured using immunohistochemistry. TUNEL and Senescence-associated beta-galactosidase (SA-beta-Gal) staining were subsequently conducted to assess the senescence and apoptosis of hepatocytes.
   Results: HFD-induced mice treated with vitamin D presented with significantly increased GSH-px levels, as well as protein expression of SOD1, SOD2, PRDX1, MTTP and PPARa, but decreased MDA and ROS levels, expression of Duox1, Duox2, ACC, SREBP1c, p53, p21 and p16, positive expression of FAS and FASL proteins as well as impaired senescence and apoptosis of hepatocytes.
   Conclusion: Active vitamin D supplementation could potentially impede hepatocyte senescence and apoptosis via suppression of the p53 pathway, thus preventing the progression of NAFLD. Our study provides available evidence on the potential clinical utility of vitamin D supplementation in NAFLD.
C1 [Liu, Yuanyuan; Cheng, Xingbo] Soochow Univ, Affiliated Hosp 1, Dept Endocrinol, 188 Shizi St, Suzhou 215006, Peoples R China.
   [Liu, Yuanyuan; Zhang, Hongman] Nanjing Med Univ, Affiliated Huaian 1 Peoples Hosp, Dept Endocrinol, Huaian 223300, Peoples R China.
   [Wang, Mengjie] Lianshui Cty Peoples Hosp, Dept Clin Lab, Huaian 223400, Peoples R China.
   [Xu, Wei] Soochow Univ, Appl Technol Coll, Dept Comp & Software Engn, Suzhou 215325, Peoples R China.
   [Qian, Weihe; Li, Xiang] Xuzhou Med Univ, Affiliated Huaian Hosp, Dept Clin Lab, 62 Huaihai South Rd, Xuzhou 223002, Jiangsu, Peoples R China.
C3 Soochow University - China; Nanjing Medical University; Soochow
   University - China; Xuzhou Medical University
RP Cheng, XB (corresponding author), Soochow Univ, Affiliated Hosp 1, Dept Endocrinol, 188 Shizi St, Suzhou 215006, Peoples R China.; Li, X (corresponding author), Xuzhou Med Univ, Affiliated Huaian Hosp, Dept Clin Lab, 62 Huaihai South Rd, Xuzhou 223002, Jiangsu, Peoples R China.
EM lixiang_suda@163.com; Xingbo1107@sohu.com
RI Wang, xiaoxiao/GQQ-2846-2022
FU Huai'an Natural Science Foundation [HAB201722]; Nanjing Medical
   University Natural Science Foundation [2016NJMU137]
FX The present study was funded by the Huai'an Natural Science Foundation
   (Grant No. HAB201722) and Nanjing Medical University Natural Science
   Foundation (Grant No. 2016NJMU137).
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NR 37
TC 26
Z9 32
U1 0
U2 20
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0024-3205
EI 1879-0631
J9 LIFE SCI
JI Life Sci.
PD JAN 15
PY 2020
VL 241
AR 117086
DI 10.1016/j.lfs.2019.117086
PG 8
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA KB0SV
UT WOS:000506211900004
PM 31756344
DA 2025-06-11
ER

PT J
AU Daniel, S
   Nylander, V
   Ingerslev, LR
   Zhong, L
   Fabre, O
   Clifford, B
   Johnston, K
   Cohn, RJ
   Barres, R
   Simar, D
AF Daniel, Sara
   Nylander, Vibe
   Ingerslev, Lars R.
   Zhong, Ling
   Fabre, Odile
   Clifford, Briana
   Johnston, Karen
   Cohn, Richard J.
   Barres, Romain
   Simar, David
TI T cell epigenetic remodeling and accelerated epigenetic aging are linked
   to long-term immune alterations in childhood cancer survivors
SO CLINICAL EPIGENETICS
LA English
DT Article
DE Epigenetic aging; DNA methylation; inflammation; cancer survivors; T
   cell
ID DNA METHYLATION; ADULT SURVIVORS; INSULIN-RESISTANCE; METABOLIC
   SYNDROME; DIABETES-MELLITUS; PERIPHERAL-BLOOD; OXIDATIVE STRESS;
   RADIATION; TRANSPLANTATION; LYMPHOCYTES
AB BackgroundCancer treatments have substantially improved childhood cancer survival but are accompanied by long-term complications, notably chronic inflammatory diseases. We hypothesize that cancer treatments could lead to long-term epigenetic changes in immune cells, resulting in increased prevalence of inflammatory diseases in cancer survivors.ResultsTo test this hypothesis, we established the epigenetic and transcriptomic profiles of immune cells from 44 childhood cancer survivors (CCS, >16years old) on full remission (>5years) who had received chemotherapy alone or in combination with total body irradiation (TBI) and hematopoietic stem cell transplant (HSCT). We found that more than 10years post-treatment, CCS treated with TBI/HSCT showed an altered DNA methylation signature in T cell, particularly at genes controlling immune and inflammatory processes and oxidative stress. DNA methylation remodeling in T cell was partially associated with chronic expression changes of nearby genes, increased frequency of type 1 cytokine-producing T cell, elevated systemic levels of these cytokines, and over-activation of related signaling pathways. Survivors exposed to TBI/HSCT were further characterized by an Epigenetic-Aging-Signature of T cell consistent with accelerated epigenetic aging. To investigate the potential contribution of irradiation to these changes, we established two cell culture models. We identified that radiation partially recapitulated the immune changes observed in survivors through a bystander effect that could be mediated by circulating factors.ConclusionCancer treatments, in particular TBI/HSCT, are associated with long-term immune disturbances. We propose that epigenetic remodeling of immune cells following cancer therapy augments inflammatory- and age-related diseases, including metabolic complications, in childhood cancer survivors.
C1 [Daniel, Sara; Clifford, Briana; Barres, Romain; Simar, David] UNSW Sydney, Mechanisms Dis & Translat Res, Sch Med Sci, Wallace Wurth Bldg East Room 420, Sydney, NSW 2052, Australia.
   [Nylander, Vibe; Ingerslev, Lars R.; Fabre, Odile; Barres, Romain; Simar, David] Univ Copenhagen, Novo Nordisk Fdn Ctr Basic Metab Res, Fac Hlth & Med Sci, Panum, DK-2200 Copenhagen N, Denmark.
   [Zhong, Ling] UNSW Sydney, Bioanalyt Mass Spectrometry Facil, Mark Wainwright Analyt Ctr, Sydney, NSW, Australia.
   [Johnston, Karen; Cohn, Richard J.] UNSW Sydney, Sch Womens & Childrens Hlth, Randwick, NSW, Australia.
   [Johnston, Karen; Cohn, Richard J.] Sydney Childrens Hosp Network, Kids Canc Ctr, Randwick, NSW, Australia.
C3 University of New South Wales Sydney; University of Copenhagen; Novo
   Nordisk Foundation; University of New South Wales Sydney; University of
   New South Wales Sydney; NSW Health; Sydney Childrens Hospitals Network
RP Barres, R; Simar, D (corresponding author), UNSW Sydney, Mechanisms Dis & Translat Res, Sch Med Sci, Wallace Wurth Bldg East Room 420, Sydney, NSW 2052, Australia.
EM barres@sund.ku.dk; d.simar@unsw.edu.au
RI Fabre, Odile/N-8371-2015; BARRES, Romain/N-2501-2016
OI Fabre, Odile/0000-0003-0892-8412; Clifford, Briana/0000-0003-4392-795X;
   Cohn, Richard/0000-0002-2400-1353; Simar, David/0000-0002-3862-1932;
   NYLANDER, VIBE/0000-0003-1511-373X; Ingerslev, Lars
   Roed/0000-0002-4164-7690; BARRES, Romain/0000-0002-0158-519X
FU Cancer Institute New South Wales [09/RFG/2-21]; Danish Diabetes Academy
   - Novo Nordisk Foundation; Novo Nordisk Foundation; UNSW Sydney
FX This work was supported by a grant from the Cancer Institute New South
   Wales (09/RFG/2-21) to R.J. Cohn and D. Simar, an International
   Postgraduate Research Scholarship from UNSW Sydney to S. Daniel, and a
   research grant from the Danish Diabetes Academy supported by the Novo
   Nordisk Foundation to O. Fabre. The Novo Nordisk Foundation Center for
   Basic Metabolic Research is an independent Research Center at the
   University of Copenhagen partially funded by an unrestricted donation
   from the Novo Nordisk Foundation.
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NR 56
TC 29
Z9 30
U1 0
U2 6
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1868-7075
EI 1868-7083
J9 CLIN EPIGENETICS
JI Clin. Epigenetics
PD NOV 6
PY 2018
VL 10
AR 138
DI 10.1186/s13148-018-0561-5
PG 13
WC Oncology; Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Genetics & Heredity
GA GZ4MT
UT WOS:000449370700002
PM 30400990
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Karamanli, H
   Kizilirmak, D
   Akgedik, R
   Bilgi, M
AF Karamanli, H.
   Kizilirmak, D.
   Akgedik, R.
   Bilgi, M. .
TI Serum levels of magnesium and their relationship with CRP in patients
   with OSA
SO SLEEP AND BREATHING
LA English
DT Article
DE Obstructive sleep apnea; Serum magnesium level; Serum CRP level;
   Inflammation
ID C-REACTIVE PROTEIN; DIETARY MAGNESIUM; CARDIOVASCULAR-DISEASE; METABOLIC
   SYNDROME; SLEEP-APNEA; INFLAMMATION; HYPERTENSION; DEFICIENCY;
   ACTIVATION; INSULIN
AB Low levels of magnesium (Mg) are associated with chronic inflammatory stress. Some animal studies have reported that a moderate deficiency of Mg, similar to that which occurs in humans, may increase inflammatory or oxidative stress stimulated by other factors, such as disrupted sleep or sleep deficiency.
   This cross-sectional study evaluated the relationship between serum levels of Mg and the inflammatory response in patients with a new diagnosis of obstructive sleep apnea (OSA).
   This clinical, retrospective study registered 68 patients with newly diagnosed mild to severe OSA and 30 without OSA. The Apnea-Hypopnea Index (AHI), oxygen desaturation index (ODI), time until blood hemoglobin oxygen saturation < 90 % (SpO(2) < 90 %), and mean blood hemoglobin SpO(2) were measured. Serum levels of Mg, plasma C-reactive protein (CRP), and total sleep time (TST) by polysomnography were also measured.
   Mg levels were lower in patients with OSA than those in controls matched for age, sex, and body mass index (BMI). Patients with OSA had substantially higher plasma CRP concentrations than controls. A negative correlation was observed between the AHI and ODI and Mg levels. Significant differences in Mg and CRP levels were observed between patients with AHI scores of 5-15 and scores >= 30 based on OSA severity but independent of BMI. Furthermore, the AHI, ODI, TST < 90 %, and mean SpO(2) significantly correlated with CRP. A significant negative correlation was observed between Mg and CRP levels (p < 0.0001).
   Our results show that Mg levels changed depending on the presence and severity of OSA. Low levels were associated with a higher CRP concentration in patients with OSA.
C1 [Karamanli, H.] Ataturk Chest Dis & Chest Surg Educ & Res Hosp, Dept Chron Resp Failure, Ankara, Turkey.
   [Kizilirmak, D.] Hakkari State Hosp, Dept Resp Med, Hakkari, Turkey.
   [Akgedik, R.] Ordu State Hosp, Dept Resp Med, Ordu, Turkey.
   [Bilgi, M. .] Mevlana Univ Hosp, Dept Internal Med, Konya, Turkey.
C3 Ataturk Chest Diseases & Thoracic Surgery Education Research Hospital;
   Hakkari State Hospital; Ordu State Hospital; Mevlana University
RP Karamanli, H (corresponding author), Ataturk Chest Dis & Chest Surg Educ & Res Hosp, Dept Chron Resp Failure, Ankara, Turkey.
EM drharun@hotmail.com
RI karamanlı, harun/I-5167-2014; Kizilirmak, Deniz/HJH-3124-2023
OI Kizilirmak, Deniz/0000-0001-9445-1598
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NR 33
TC 14
Z9 14
U1 0
U2 6
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1520-9512
EI 1522-1709
J9 SLEEP BREATH
JI Sleep Breath.
PD MAY
PY 2017
VL 21
IS 2
BP 549
EP 556
DI 10.1007/s11325-016-1402-4
PG 8
WC Clinical Neurology; Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Respiratory System
GA ET1DS
UT WOS:000400006800044
PM 27600660
DA 2025-06-11
ER

PT J
AU Jiang, QX
   Hao, RR
   Wang, WC
   Gao, H
   Wang, CB
AF Jiang, Qixiao
   Hao, Ranran
   Wang, Wencheng
   Gao, Hui
   Wang, Chunbo
TI SIRT1/Atg5/autophagy are involved in the antiatherosclerosis effects of
   ursolic acid
SO MOLECULAR AND CELLULAR BIOCHEMISTRY
LA English
DT Article
DE Ursolic acid; Atherosclerosis; SIRT1; Atg5; Autophagy
ID LOW-DENSITY-LIPOPROTEIN; FOAM CELL-FORMATION; SPIN-RESONANCE ESR;
   ENDOTHELIAL-CELLS; METABOLIC SYNDROME; DEACETYLASE SIRT1; OXIDIZED LDL;
   DNA-DAMAGE; ATHEROSCLEROSIS; AUTOPHAGY
AB The purpose of this study was to investigate the antiatherosclerosis effects of ursolic acid (UA) in high-fat diet-fed quails (Coturnix coturnix) and potential mechanism. Quails were treated with high-fat diet (14 % pork oil, 1 % cholesterol w/w) with or without UA (50, 150, or 300 mg/kg/day) for 10 weeks. Serum lipid profile was assessed at 0, 4.5, and 10 weeks. After 10 weeks, serum antioxidant status and morphology of aorta were assessed. Additionally, human umbilical vein endothelial cells (HUVECs) were exposed to 100 mu g/ml oxidized low-density lipoprotein (ox-LDL) for 24 h, with or without pretreatment with UA (5, 10 or 20 mu M) for 16 h, autophagy inhibitor 3-MA 5 mM for 2 h, or SIRT1 inhibitor EX-527 10 mu M for 2 h. Cell viability and oxidative stress status were assessed and autophagy status was determined. Acetylation of lysine residue on Atg5 was assessed with immunoprecipitation. In results, high-fat diet negatively affected serum lipid profile and antioxidant status in quails and induced significant histological changes. Cotreatment with UA remarkably alleviated such changes. In HUVECs, ox-LDL treatment induced significant cytotoxicity along with oxidative stress, while UA cotreatment alleviated such changes significantly. UA treatment induced autophagy, enhanced SIRT1 expression, and decreased acetylation of lysine residue on Atg5. Cotreatment with 3-MA or EX-527 effectively abolished UA's protective effects. In summary, UA exerted antiatherosclerosis effects in quails and protected HUVECs from ox-LDL induced cytotoxicity, and the mechanism is associated with increased SIRT1 expression, decreased Atg5 acetylation on lysine residue, and increased autophagy.
C1 [Jiang, Qixiao; Hao, Ranran; Gao, Hui; Wang, Chunbo] Qingdao Univ, Dept Pharmacol, Coll Med, Boya Bldg Room 422,308 Ningxia Rd, Qingdao 266071, Shandong, Peoples R China.
   [Wang, Wencheng] Inst Human Nutr Med Coll, 38 Dengzhou Rd, Qingdao 266071, Shandong, Peoples R China.
C3 Qingdao University
RP Wang, CB (corresponding author), Qingdao Univ, Dept Pharmacol, Coll Med, Boya Bldg Room 422,308 Ningxia Rd, Qingdao 266071, Shandong, Peoples R China.
EM cbwang666@126.com
FU National Natural Science Foundation of China [81173593]
FX The authors thank the affiliated hospital of Qingdao University for
   providing necessary instruments. This study was funded by the National
   Natural Science Foundation of China (Grant No. 81173593), received by
   Chunbo Wang.
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NR 48
TC 37
Z9 41
U1 2
U2 22
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0300-8177
EI 1573-4919
J9 MOL CELL BIOCHEM
JI Mol. Cell. Biochem.
PD SEP
PY 2016
VL 420
IS 1-2
BP 171
EP 184
DI 10.1007/s11010-016-2787-x
PG 14
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA DU3LL
UT WOS:000382112200017
PM 27514536
DA 2025-06-11
ER

PT J
AU Aghamohammadzadeh, R
   Greenstein, AS
   Yadav, R
   Jeziorska, M
   Hama, S
   Soltani, F
   Pemberton, PW
   Ammori, B
   Malik, RA
   Soran, H
   Heagerty, AM
AF Aghamohammadzadeh, Reza
   Greenstein, Adam S.
   Yadav, Rahul
   Jeziorska, Maria
   Hama, Salam
   Soltani, Fardad
   Pemberton, Phil W.
   Ammori, Basil
   Malik, Rayaz A.
   Soran, Handrean
   Heagerty, Anthony M.
TI Effects of Bariatric Surgery on Human Small Artery Function Evidence for
   Reduction in Perivascular Adipocyte Inflammation, and the Restoration of
   Normal Anticontractile Activity Despite Persistent Obesity
SO JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
LA English
DT Article
DE bariatric; cardiovascular; obesity
ID PERIADVENTITIAL ADIPOSE-TISSUE; WEIGHT-LOSS; INSULIN-RESISTANCE;
   NITRIC-OXIDE; HYPOXIA; DYSFUNCTION; PATHOPHYSIOLOGY; MECHANISMS;
   VESSELS; FAT
AB Objectives The aim of this study was to investigate the effects of bariatric surgery on small artery function and the mechanisms underlying this.
   Background In lean healthy humans, perivascular adipose tissue (PVAT) exerts an anticontractile effect on adjacent small arteries, but this is lost in obesity-associated conditions such as the metabolic syndrome and type II diabetes where there is evidence of adipocyte inflammation and increased oxidative stress.
   Methods Segments of small subcutaneous artery and perivascular fat were harvested from severely obese individuals before (n = 20) and 6 months after bariatric surgery (n = 15). Small artery contractile function was examined in vitro with wire myography, and perivascular adipose tissue (PVAT) morphology was assessed with immunohistochemistry.
   Results The anticontractile activity of PVAT was lost in obese patients before surgery when compared with healthy volunteers and was restored 6 months after bariatric surgery. In vitro protocols with superoxide dismutase and catalase rescued PVAT anticontractile function in tissue from obese individuals before surgery. The improvement in anticontractile function after surgery was accompanied by improvements in insulin sensitivity, serum glycemic indexes, inflammatory cytokines, adipokine profile, and systolic blood pressure together with increased PVAT adiponectin and nitric oxide bioavailability and reduced macrophage infiltration and inflammation. These changes were observed despite the patients remaining severely obese.
   Conclusions Bariatric surgery and its attendant improvements in weight, blood pressure, inflammation, and metabolism collectively reverse the obesity-induced alteration to PVAT anticontractile function. This reversal is attributable to reductions in local adipose inflammation and oxidative stress with improved adiponectin and nitric oxide bioavailability. (C) 2013 by the American College of Cardiology Foundation
C1 [Aghamohammadzadeh, Reza; Greenstein, Adam S.; Yadav, Rahul; Jeziorska, Maria; Hama, Salam; Malik, Rayaz A.; Soran, Handrean; Heagerty, Anthony M.] Univ Manchester, Cardiovasc Res Grp, Manchester, Lancs, England.
   [Aghamohammadzadeh, Reza; Greenstein, Adam S.; Yadav, Rahul; Hama, Salam; Soltani, Fardad; Pemberton, Phil W.; Malik, Rayaz A.; Soran, Handrean; Heagerty, Anthony M.] Manchester Wellcome Trust Clin Res Facil, Manchester, Lancs, England.
   [Pemberton, Phil W.] Manchester Royal Infirm, Dept Clin Biochem, Manchester M13 9WL, Lancs, England.
   [Ammori, Basil] Salford Royal NHS Fdn Trust, Manchester, Lancs, England.
C3 University of Manchester; University of Manchester; University of
   Manchester; Salford Royal NHS Foundation Trust
RP Aghamohammadzadeh, R (corresponding author), Core Technol Facil, Cardiovasc Res Grp, 3rd Floor,46 Grafton St, Manchester M13 9NT, Lancs, England.
EM reza.zadeh@manchester.ac.uk
RI Malik, Rayaz/H-9231-2019; Jeziorska, Maria/P-1731-2015
OI Greenstein, Adam/0000-0002-5274-4189; Heagerty,
   Anthony/0000-0002-9043-2119; Malik, Rayaz/0000-0002-7188-8903; Yadav,
   Rahul/0000-0002-8351-5792; Soltani, Fardad/0000-0003-2030-9761;
   Jeziorska, Maria/0000-0002-3492-0177
FU British Heart Foundation [FS/10/42/ 28372, FS11/68/28821,
   FS12/81/29882]; NIHR Manchester Biomedical Research Centre; Wellcome
   Trust Clinical Research Facility (Manchester, United Kingdom)
FX This study was funded by 2 Clinical Research Fellowships awarded to Dr.
   Aghamohammadzadeh (British Heart Foundation [FS/10/42/ 28372] and NIHR
   Manchester Biomedical Research Centre); and the support of Wellcome
   Trust Clinical Research Facility (Manchester, United Kingdom). Dr.
   Greenstein was funded by the British Heart Foundation (FS11/68/28821).
   Drs. Greenstein and Heagerty were funded by the British Heart Foundation
   (FS12/81/29882). All other authors have reported that they have no
   relationships relevant to the contents of this paper to disclose.
CR Aghamohammadzadeh R, 2012, ANN MED, V44, pS74, DOI 10.3109/07853890.2012.663928
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NR 37
TC 135
Z9 144
U1 0
U2 16
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0735-1097
EI 1558-3597
J9 J AM COLL CARDIOL
JI J. Am. Coll. Cardiol.
PD JUL 9
PY 2013
VL 62
IS 2
BP 128
EP 135
DI 10.1016/j.jacc.2013.04.027
PG 8
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 176WY
UT WOS:000321338600008
PM 23665100
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Davidson, EP
   Coppey, LJ
   Calcutt, NA
   Oltman, CL
   Yorek, MA
AF Davidson, Eric P.
   Coppey, Lawrence J.
   Calcutt, Nigel A.
   Oltman, Christine L.
   Yorek, Mark A.
TI Diet-induced obesity in Sprague - Dawley rats causes microvascular and
   neural dysfunction
SO DIABETES-METABOLISM RESEARCH AND REVIEWS
LA English
DT Article
DE obesity; vascular function; neutral endopeptidase; neuropathy
ID INDUCED DIABETIC-RATS; NEUTRAL ENDOPEPTIDASE ACTIVITY; IMPAIRED
   GLUCOSE-TOLERANCE; GENE-RELATED PEPTIDE; FREE FATTY-ACIDS; EPINEURIAL
   ARTERIOLES; INCREASED PREVALENCE; VASCULAR REACTIVITY; METABOLIC
   SYNDROME; SCIATIC-NERVE
AB Background The objective of this study was to determine the effect of diet-induced obesity (DIO) on microvascular and neural function.
   Methods Rats were fed a standard or high fat diet for up to 32 weeks. The following measurements were carried out: vasodilation in epineurial arterioles using videomicroscopy, endoneurial blood flow using hydrogen clearance, nerve conduction velocity using electrical stimulation, size frequency distribution of myelinated fibres of the sciatic nerve, intraepidermal nerve fibre density using confocal microscopy and thermal nociception using the Hargreaves method.
   Results Rats fed a high fat diet for 32 weeks developed sensory neuropathy, as indicated by slowing of sensory nerve conduction velocity and thermal hypoalgesia. Motor nerve conduction velocity and endoneurial blood flow were not impaired. Mean axonal diameter of myelinated fibres of the sciatic nerve was unchanged in high fat-fed rats compared with that in control. Intraepidermal nerve fibre density was significantly reduced in high fat-fed rats. Vascular relaxation to acetylcholine and calcitonin gene-related peptide was decreased and expression of neutral endopeptidase (NEP) increased in epineurial arterioles of rats fed a high fat diet. In contrast, insulin-mediated vascular relaxation was increased in epineurial arterioles. NEP activity was significantly increased in the skin of the hindpaw. Markers of oxidative stress were increased in the aorta and serum of high fat-fed rats but not in epineurial arterioles.
   Conclusion Chronic obesity causes microvascular and neural dysfunction. This is associated with increased expression of NEP but not oxidative stress in epineurial arterioles. NEP degrades vasoactive peptides, which may explain the decrease in microvascular function. Copyright (C) 2010 John Wiley & Sons, Ltd.
C1 [Davidson, Eric P.; Coppey, Lawrence J.; Oltman, Christine L.; Yorek, Mark A.] Univ Iowa, Vet Affairs Med Ctr, Iowa City, IA 52246 USA.
   [Calcutt, Nigel A.] Univ Calif San Diego, Dept Pathol, La Jolla, CA 92093 USA.
   [Oltman, Christine L.; Yorek, Mark A.] Univ Iowa, Dept Internal Med, Iowa City, IA 52242 USA.
C3 US Department of Veterans Affairs; Veterans Health Administration (VHA);
   Iowa City VA Health Care System; University of Iowa; University of
   California System; University of California San Diego; University of
   Iowa
RP Yorek, MA (corresponding author), Univ Iowa, Vet Affairs Med Ctr, Bldg 40,Room 204, Iowa City, IA 52246 USA.
EM mark-yorek@uiowa.edu
RI Yorek, Mark/AAC-3136-2021
OI Yorek, Mark/0000-0001-7737-5554
FU Department of Veterans Affairs, Veterans Health Administration, Office
   of Research and Development, Biomedical Laboratory Research and
   Development; National Institute of Diabetes and Digestive and Kidney
   Diseases [DK073990, DK057629]
FX This material is based upon work supported in part by the Department of
   Veterans Affairs, Veterans Health Administration, Office of Research and
   Development, Biomedical Laboratory Research and Development and by
   National Institute of Diabetes and Digestive and Kidney Diseases Grants
   DK073990 (MAY) and DK057629 (NAC) from NIH. The authors express their
   thanks to Ms Veronica Lopez for excellent technical support. The content
   of this work are new and solely the responsibility of the authors, and
   do not necessarily represent the official views of the granting
   agencies.
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NR 64
TC 72
Z9 79
U1 1
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1520-7552
EI 1520-7560
J9 DIABETES-METAB RES
JI Diabetes-Metab. Res. Rev.
PD MAY
PY 2010
VL 26
IS 4
BP 306
EP 318
DI 10.1002/dmrr.1088
PG 13
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 609MJ
UT WOS:000278660400010
PM 20503263
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Bidel, S
   Silventoinen, K
   Hu, G
   Lee, DH
   Kaprio, J
   Tuomilehto, J
AF Bidel, S.
   Silventoinen, K.
   Hu, G.
   Lee, D-H
   Kaprio, J.
   Tuomilehto, J.
TI Coffee consumption, serum γ-glutamyltransferase and risk of type II
   diabetes
SO EUROPEAN JOURNAL OF CLINICAL NUTRITION
LA English
DT Article
DE type II diabetes; coffee; gamma-glutamyltransferase; oxidative stress;
   glutathione
ID AGED JAPANESE MEN; GASTRIC-INHIBITORY POLYPEPTIDE; IMPAIRED
   GLUCOSE-TOLERANCE; NONALCOHOLIC FATTY LIVER; METABOLIC SYNDROME;
   PHYSICAL-ACTIVITY; OXIDATIVE STRESS; FASTING GLUCOSE; FINNISH MEN;
   MELLITUS
AB Objectives: To study the joint association of coffee consumption and serum gamma-glutamyltransferase (GGT) levels on the risk of developing type II diabetes.
   Design, setting and subjects: A total of 21 826 Finnish men and women who were 35-74 years of age and without any history of diabetes at baseline (years 1982, 1987, 1992 and 1997) were included in the present analyses. They were prospectively followed up for onset of type II diabetes (n = 862 cases), death or until the end of the year 2002. Coffee consumption, serum GGT and other study parameters were determined at baseline using standardized measurements. Analyses were stratified by the serum GGT level classified into two classes using the 75th sex-specific percentiles as the cut point.
   Results: Coffee consumption was significantly and inversely associated with incident diabetes among both men and women. Serum GGT modified the association between coffee consumption and incident diabetes. Subjects in the high category of coffee consumption with the GGT level >= 75th percentile showed a significant inverse association for women, and for both sexes combined. The association was not significant in subjects with the GGT level <= 75th percentile. There was a significant interaction effect of GGT and coffee consumption on risk of type II diabetes in data of women (P = 0.05) and in both sexes combined (P = 0.02).
   Conclusions: Habitual coffee consumption is associated with lower incidence of type II diabetes particularly in those with higher baseline serum GGT levels.
C1 [Bidel, S.; Hu, G.; Tuomilehto, J.] Natl Publ Hlth Inst, Dept Hlth Promot & Chron Dis, Diabet Unit, FIN-00300 Helsinki, Finland.
   [Bidel, S.; Silventoinen, K.; Hu, G.; Kaprio, J.; Tuomilehto, J.] Univ Helsinki, Dept Publ Hlth, FIN-00014 Helsinki, Finland.
   [Lee, D-H] Kyungpook Natl Univ, Sch Med, Dept Prevent Med, Taegu, South Korea.
   [Kaprio, J.] Natl Publ Hlth Inst, Dept Mental Hlth & Alcohol Res, Helsingor, Denmark.
   [Tuomilehto, J.] S Ostrobothnia Cent Hosp, Seinajoki, Finland.
C3 Finland National Institute for Health & Welfare; University of Helsinki;
   Kyungpook National University (KNU)
RP Bidel, S (corresponding author), Natl Publ Hlth Inst, Dept Hlth Promot & Chron Dis, Diabet Unit, Mannerheimintie 166, FIN-00300 Helsinki, Finland.
EM siamak.bidel@ktl.fi
RI Kaprio, Jaakko/A-1820-2008; Hu, Gang/V-7947-2019; tuomilehto,
   jaakko/E-6504-2011; Hu, Gang/N-1971-2017
OI Silventoinen, Karri/0000-0003-1759-3079; Hu, Gang/0000-0002-6172-8017;
   Kaprio, Jaakko/0000-0002-3716-2455
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NR 61
TC 36
Z9 37
U1 1
U2 9
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0954-3007
J9 EUR J CLIN NUTR
JI Eur. J. Clin. Nutr.
PD FEB
PY 2008
VL 62
IS 2
BP 178
EP 185
DI 10.1038/sj.ejcn.1602712
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 259IL
UT WOS:000252932900004
PM 17342160
DA 2025-06-11
ER

PT J
AU Ildarabadi, A
   Vahid-Dastjerdi, M
   Ghorbanpour, M
   Mousavi, A
   Meshkani, M
   Yekaninejad, M
   Saedisomeolia, A
AF Ildarabadi, Azam
   Vahid-Dastjerdi, Marzieh
   Ghorbanpour, Mina
   Mousavi, Ahmad
   Meshkani, Mehrnoush
   Yekaninejad, Mirsaeed
   Saedisomeolia, Ahmad
TI Effects of green coffee supplementation on paraoxonase-1 activity and
   malondialdehyde levels in Iranian women with polycystic ovary syndrome:
   a randomized clinical trial
SO OSONG PUBLIC HEALTH AND RESEARCH PERSPECTIVES
LA English
DT Article
DE Chlorogenic acid; Glycemic index; Green coffee; Lipid profile;
   Polycystic ovary syndrome
ID CHLOROGENIC ACID; OXIDATIVE STRESS; BEAN EXTRACT; ANTHROPOMETRIC
   INDEXES; METABOLIC SYNDROME; GLYCEMIC CONTROL; BLOOD-PRESSURE; SYNDROME
   PCOS; DOUBLE-BLIND; QUESTIONNAIRE
AB Objectives: Polycystic ovary syndrome (PCOS) is a common, heterogeneous clinical syndrome affecting women. Investigating oxidative stress in women is crucial, as it is linked to insulin resistance and endothelial dysfunction. Chlorogenic acid, a bioactive component found in green coffee, has numerous documented health benefits. This study aimed to assess the beneficial effects of green coffee consumption on paraoxonase-1(PON-1) activity and malondialdehyde (MDA) levels in women with PCOS. Methods: This study was a double-blind randomized clinical trial that included 44 patients with PCOS. Participants were randomly assigned to either the intervention or control group. For 6 weeks, the intervention group ( n = 22) received 400 mg of green coffee supplements, while the control group ( n = 22) received 400 mg of a starch-based placebo. Anthropometric indices, dietary assessments, and physical activity levels were evaluated before and after the 6-week intervention period. Additionally, blood samples were collected for laboratory analysis. Results: Supplementation with green coffee increased PON-1 levels by 3.5 units, a significant finding (p= 0.038). Additionally, the intake of green coffee supplements significantly reduced blood cholesterol levels by 18.8 units (p= 0.013) and triglyceride levels by 6.1 units (p= 0.053). However, no significant differences were observed in the levels of MDA, high-density lipoprotein, low-density lipoprotein, fasting blood sugar, insulin, or homeostatic model assessment of insulin resistance as a result of the intervention. Conclusion: Supplementation with green coffee alters PON-1 activity and cholesterol levels in women with PCOS. it has no on MDA levels or status.
C1 [Ildarabadi, Azam; Mousavi, Ahmad; Meshkani, Mehrnoush] Islamic Azad Univ, Fac Med Sci & Technol, Dept Nutr Sci, Sci & Res Branch, Tehran, Iran.
   [Vahid-Dastjerdi, Marzieh] Univ Tehran Med Sci, Sch Med, Dept Obstet & Gynecol, Tehran, Iran.
   [Ghorbanpour, Mina] Univ Tehran Med Sci, Univ Res & Dev Ctr, Tehran, Iran.
   [Yekaninejad, Mirsaeed] Univ Tehran Med Sci, Sch Publ Hlth, Dept Epidemiol & Biostat, Tehran, Iran.
   [Saedisomeolia, Ahmad] Higher Educ Coll Hlth Sci, Educ Ctr Australia, Parramatta, NSW, Australia.
   [Saedisomeolia, Ahmad] McGill Univ, Res Scientist Affiliate Sch Human Nutr, Montreal, PQ, Canada.
C3 Islamic Azad University; Tehran University of Medical Sciences; Tehran
   University of Medical Sciences; Tehran University of Medical Sciences;
   McGill University
RP Saedisomeolia, A (corresponding author), Educ Ctr Australia, Higher Educ Coll Hlth Sci, Parramatta Campus,1-3 Fitzwilliam, St Parramatta, NSW 2150, Australia.
EM ahmad.saedisomeolia@chs.edu.au
RI ; Yekaninejad, Mir Saeed/L-6752-2016
OI Ildarabadi, Azam/0000-0001-9329-7082; Yekaninejad, Mir
   Saeed/0000-0003-3648-5276
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NR 72
TC 1
Z9 1
U1 0
U2 1
PU KOREA DISEASE CONTROL & PREVENTION AGENCY
PI CHEONGJU SI
PA NATL CTR MEDICAL INFORMATION & KNOWLEDGE, 202, OSONGSENGMYUNG 2 ST,
   OSONG EUP, CHEONGJU SI,   CHUNGCHEONGBUK DO, SOUTH KOREA
SN 2210-9099
EI 2233-6052
J9 OSONG PUBLIC HEALTH
JI Osong Public Health Res. Perspect.
PD DEC
PY 2024
VL 15
IS 6
BP 521
EP 532
DI 10.24171/j.phrp.2024.0187
PG 12
WC Public, Environmental & Occupational Health
WE Emerging Sources Citation Index (ESCI)
SC Public, Environmental & Occupational Health
GA S4Y6J
UT WOS:001398298900006
PM 39562530
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Ochsner, SA
   Tsimelzon, A
   Dong, JR
   Coarfa, C
   McKenna, NJ
AF Ochsner, Scott A.
   Tsimelzon, Anna
   Dong, Jianrong
   Coarfa, Cristian
   McKenna, Neil J.
TI Research Resource: A Reference Transcriptome for Constitutive Androstane
   Receptor and Pregnane X Receptor Xenobiotic Signaling
SO MOLECULAR ENDOCRINOLOGY
LA English
DT Article
ID ACETAMINOPHEN-INDUCED HEPATOTOXICITY; CENTRAL-NERVOUS-SYSTEM;
   KAPPA-B-ZETA; OXIDATIVE STRESS; NUCLEAR; METABOLISM; EXPRESSION; CAR;
   COACTIVATOR; PGC-1-ALPHA
AB The pregnane X receptor (PXR) (PXR/NR1I3) and constitutive androstane receptor (CAR) (CAR/NR1I2) members of the nuclear receptor (NR) superfamily of ligand-regulated transcription factors are well-characterized mediators of xenobiotic and endocrine-disrupting chemical signaling. The Nuclear Receptor Signaling Atlas maintains a growing library of transcriptomic datasets involving perturbations of NR signaling pathways, many of which involve perturbations relevant to PXR and CAR xenobiotic signaling. Here, we generated a reference transcriptome based on the frequency of differential expression of genes across 159 experiments compiled from 22 datasets involving perturbations of CAR and PXR signaling pathways. In addition to the anticipated overrepresentation in the reference transcriptome of genes encoding components of the xenobiotic stress response, the ranking of genes involved in carbohydrate metabolism and gonadotropin action sheds mechanistic light on the suspected role of xenobiotics in metabolic syndrome and reproductive disorders. Gene Set Enrichment Analysis showed that although acetaminophen, chlorpromazine, and phenobarbital impacted many similar gene sets, differences in direction of regulation were evident in a variety of processes. Strikingly, gene sets representing genes linked to Parkinson's, Huntington's, and Alzheimer's diseases were enriched in all 3 transcriptomes. The reference xenobiotic transcriptome will be supplemented with additional future datasets to provide the community with a continually updated reference transcriptomic dataset for CAR-and PXR-mediated xenobiotic signaling. Our study demonstrates how aggregating and annotating transcriptomic datasets, and making them available for routine data mining, facilitates research into the mechanisms by which xenobiotics and endocrine-disrupting chemicals subvert conventional NR signaling modalities.
C1 [Ochsner, Scott A.; Dong, Jianrong; Coarfa, Cristian; McKenna, Neil J.] Baylor Coll Med, Dept Mol Biol, Houston, TX 77030 USA.
   [Ochsner, Scott A.; Dong, Jianrong; Coarfa, Cristian; McKenna, Neil J.] Baylor Coll Med, Dept Cellular Biol, Houston, TX 77030 USA.
   [Tsimelzon, Anna] Baylor Coll Med, Lester & Sue Smith Breast Ctr, Houston, TX 77030 USA.
   [Ochsner, Scott A.; McKenna, Neil J.] Baylor Coll Med, Nucl Receptor Signaling Atlas Informat Grp, Houston, TX 77030 USA.
C3 Baylor College of Medicine; Baylor College of Medicine; Baylor College
   of Medicine; Baylor College of Medicine
RP McKenna, NJ (corresponding author), Baylor Coll Med, Dept Mol & Cellular Biol, Houston, TX 77030 USA.
EM nmckenna@bcm.edu
RI Ochsner, Scott/B-3045-2013
OI Ochsner, Scott/0000-0003-1099-7863
FU Nuclear Receptor Signaling Atlas Consortium from National Institute of
   Diabetes Digestive and Kidney Diseases and National Institute of Child
   Health and Development [DK097748, DK097748-S3]
FX The Nuclear Receptor Signaling Atlas Consortium was funded for this
   research by awards from National Institute of Diabetes Digestive and
   Kidney Diseases and National Institute of Child Health and Development
   (DK097748 and DK097748-S3).
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NR 94
TC 4
Z9 5
U1 0
U2 22
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0888-8809
EI 1944-9917
J9 MOL ENDOCRINOL
JI Mol. Endocrinol.
PD AUG
PY 2016
VL 30
IS 8
BP 937
EP 948
DI 10.1210/me.2016-1095
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA DU0ZB
UT WOS:000381932700011
PM 27409825
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU DeClercq, V
   d'Eon, B
   McLeod, RS
AF DeClercq, Vanessa
   d'Eon, Brandon
   McLeod, Roger S.
TI Fatty acids increase adiponectin secretion through both classical and
   exosome pathways
SO BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
LA English
DT Article
DE Adiponectin; Fatty acids; Adipocytes; Oligomer assembly; Secretory
   pathway
ID TYPE-2 DIABETIC-PATIENTS; ENDOPLASMIC-RETICULUM STRESS; MEDIATED PROTEIN
   RETENTION; ADIPOSE-SPECIFIC PROTEIN; PPAR-GAMMA; PLASMA ADIPONECTIN;
   METABOLIC SYNDROME; CIRCULATING ADIPONECTIN; INSULIN SENSITIVITY; SERUM
   ADIPONECTIN
AB Little is known about the effects of fatty acids on adiponectin oligomer assembly and trafficking. The aim of this study was to examine the effects of different fatty acids on adiponectin transport and secretion in differentiated 3T3-L1 adipocytes. Subcellular fractionation and immunofluorescence microscopy revealed that the majority of cellular adiponectin was located in the endoplasmic reticulum (ER). Adiponectin secretion was increased by treatment with fatty adds, including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), and several fatty acids changed the cellular localization of adiponectin. Adiponectin secretion has been shown to be altered by ER stress and interactions with ER chaperone proteins. However these mechanisms were not influenced by fatty acids, suggesting that alternative mechanisms must be responsible for the increased secretion of adiponectin observed with fatty acid treatment. Secretion of adiponectin was blocked by Brefeldin A, but we identified a minor pool of adiponectin that could be secreted from beyond the Brefeldin A block. Exosomes appeared to contribute to a minor amount of adiponectin secreted from the cell, and exosome release was increased by treatment with DHA. These data suggest that the ER is an important site of adiponectin accumulation and that treatment with long chain omega-3 fatty acids increases adiponectin release. Furthermore, the secretory pathway of adiponectin is complex, involving both the classical ER-Golgi pathway as well as unconventional secretory mechanisms such as an exosome-mediated pathway. (C) 2015 Elsevier B.V. All rights reserved.
C1 [DeClercq, Vanessa; d'Eon, Brandon; McLeod, Roger S.] Dalhousie Univ, Dept Biochem &Molecular Biol, Halifax, NS B3H 4R2, Canada.
C3 Dalhousie University
RP McLeod, RS (corresponding author), Dalhousie Univ, Dept Biochem &Molecular Biol, Rm 9C,Sir Charles Tupper Med Bldg,5850 Coll St, Halifax, NS B3H 4R2, Canada.
EM rmcleod2@dal.ca
RI DeClercq, Vanessa/AES-0016-2022; McLeod, Roger/F-8014-2015
OI d'Eon, Brandon/0000-0002-9124-0151; McLeod, Roger/0000-0002-6740-5569
FU Heart and Stroke Foundation of Nova Scotia
FX This work was supported by funding from the Heart and Stroke Foundation
   of Nova Scotia.
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NR 73
TC 36
Z9 39
U1 0
U2 30
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1388-1981
EI 0006-3002
J9 BBA-MOL CELL BIOL L
JI Biochim. Biophys. Acta Mol. Cell Biol. Lipids
PD SEP
PY 2015
VL 1851
IS 9
BP 1123
EP 1133
DI 10.1016/j.bbalip.2015.04.005
PG 11
WC Biochemistry & Molecular Biology; Biophysics; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Cell Biology
GA CO4YY
UT WOS:000359168000003
PM 25900100
DA 2025-06-11
ER

PT J
AU Roberts, CK
   Chen, BH
   Pruthi, S
   Lee, ML
AF Roberts, Christian K.
   Chen, Brian H.
   Pruthi, Sandeep
   Lee, Martin L.
TI Effects of varying doses of testosterone on atherogenic markers in
   healthy younger and older men
SO AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE
   PHYSIOLOGY
LA English
DT Article
DE atherosclerosis; androgen; inflammation; oxidative stress; adhesion;
   chemotaxis
ID MIDDLE-AGED MEN; CARDIOVASCULAR RISK-FACTORS; HORMONE-BINDING GLOBULIN;
   CORONARY-HEART-DISEASE; LOW SERUM TESTOSTERONE; C-REACTIVE PROTEIN;
   ENDOGENOUS TESTOSTERONE; METABOLIC SYNDROME; SEX-HORMONES; ELDERLY-MEN
AB Whether exogenous testosterone is proatherogenic remains controversial. We assessed the effects of graded doses of testosterone on serum markers of oxidative stress, chemotaxis, adhesion, and inflammation in healthy younger and older men. In a double-blind, randomized trial, 121 eugonadal men (n = 61, 18-35 years of age and n = 60, 60-75 years of age) were randomized to one of five groups to receive weekly injections of 25, 50, 125, 300, or 600 mg of testosterone enanthate for 20 wk, respectively, along with a long-acting gonadotropin-releasing hormone (GnRH) agonist. Energy and protein intakes were standardized and no resistance training was allowed. We measured plasma levels of the atherogenic biomarkers monocyte chemotactic protein-1 (MCP-1), soluble intracellular adhesion molecule-1 (sICAM-1), 8-isoprostane-PGF(2 alpha) (8-iso-PGF(2 alpha)), and high-sensitivity C-reactive protein (hs-CRP) before and after the intervention. Administration of increasing doses of testosterone led to reduction in total 8-iso-PGF(2 alpha) in the younger (p-trend(Younger) = 0.01), but not older (p-trend(Older) = 0.79) men. No significant linear associations were observed between testosterone dose and MCP-1, sICAM-1, or hs-CRP (all p-trend > 0.20). In apparently healthy men, over a wide dose range, testosterone did not adversely affect atherogenic biomarkers. Long-term studies with larger sample sizes are warranted to determine whether testosterone supplementation affects atherosclerosis progression and cardiovascular risk.
C1 [Roberts, Christian K.; Chen, Brian H.; Pruthi, Sandeep] Univ Calif Los Angeles, Sch Nursing, Exercise & Metab Dis Res Lab, Translat Sci Sect, Los Angeles, CA 90095 USA.
   [Lee, Martin L.] Univ Calif Los Angeles, Sch Publ Hlth, Dept Biostat, Los Angeles, CA 90095 USA.
C3 University of California System; University of California Los Angeles;
   University of California System; University of California Los Angeles
RP Roberts, CK (corresponding author), Univ Calif Los Angeles, Sch Nursing, Exercise & Metab Dis Res Lab, Translat Sci Sect, Los Angeles, CA 90095 USA.
EM croberts@ucla.edu
RI Chen, Brian/KWU-5637-2024
OI Chen, Brian/0000-0001-9065-3301
FU American Heart Association (BGIA) [0765139Y]; American Heart Association
   (AHA) [0765139Y] Funding Source: American Heart Association (AHA)
FX C.K. Roberts was supported by the American Heart Association (BGIA no.
   0765139Y) during writing of this paper.
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NR 43
TC 6
Z9 8
U1 0
U2 1
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0363-6119
EI 1522-1490
J9 AM J PHYSIOL-REG I
JI Am. J. Physiol.-Regul. Integr. Comp. Physiol.
PD JAN
PY 2014
VL 306
IS 2
BP R118
EP R123
DI 10.1152/ajpregu.00372.2013
PG 6
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA 291TX
UT WOS:000329854000004
PM 24305063
DA 2025-06-11
ER

PT J
AU Chai, SC
   Arjmandi, BH
AF Chai, Sheau C.
   Arjmandi, Bahram H.
TI Vitamin E dose-dependently reduces aortic fatty lesion formation in
   orchidectomized aged rats
SO AGING CLINICAL AND EXPERIMENTAL RESEARCH
LA English
DT Article
DE Androgen; atherosclerosis; rat; tocopherol
ID LOW-DENSITY LIPOPROTEINS; E-DEFICIENT MICE; MYOCARDIAL-INFARCTION;
   LIPID-PEROXIDATION; PLASMA-CHOLESTEROL; ANTIOXIDANT STATUS; METABOLIC
   SYNDROME; OXIDATIVE STRESS; ATHEROSCLEROSIS; MEN
AB Background and aims: Although the cardioprotective effects of supplemental doses of vitamin E have been investigated in several conditions, its role in gonadectomy-induced fatty lesion formation is unclear. The present study was designed to examine the efficacy of vitamin E in a dose-dependent manner on indices of oxidative stress and in preventing the formation of aortic fatty lesions in orchidectomized (Orx) aged rats. Methods: Forty 12-month old male Sprague-Dawley rats were either sham-operated (Sham) or Orx and fed a semi-purified control diet for 120 days. Thereafter, rats were assigned to four treatment groups (n=10): Sham and one Orx group received 75 IU vitamin E and served as controls, and the other two Orx groups received either 250 or 500 IU vitamin E per kg diet for 90 days. Results: Vitamin E at the highest dose (500 IU) was able to lower serum total cholesterol by 16% and significantly increase superoxide dismutase by 9% compared to Orx controls. Similarly, this dose was able to significantly reduce the development of atherosclerotic lesion formation and aortic fatty streak area by 93% compared to Orx controls. Conclusions: The findings of this study suggest that dietary vitamin E supplementation in Orx aged rats provide anti-atherogenic effects, in part, due to vitamin E's antioxidative properties. Clinical studies are needed to confirm whether supplemental doses of vitamin E can prevent the development of atherosclerosis in older men particularly with low testosterone level. (Aging Clin Exp Res 2011; 23: 11-16) (C)2011, Editrice Kurtis
C1 [Chai, Sheau C.; Arjmandi, Bahram H.] Florida State Univ, Dept Nutr Food & Exercise Sci, Tallahassee, FL 32306 USA.
C3 State University System of Florida; Florida State University
RP Arjmandi, BH (corresponding author), Florida State Univ, Dept Nutr Food & Exercise Sci, 436 Sandels Bldg, Tallahassee, FL 32306 USA.
EM barjmandi@fsu.edu
RI Arjmandi, Bahram/GRY-0474-2022; Chai, Sheau/J-5494-2019
OI Arjmandi, Bahram/0000-0003-1358-0238; Chai, Sheau/0000-0003-3969-8912
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NR 46
TC 2
Z9 2
U1 0
U2 4
PU EDITRICE KURTIS S R L
PI MILAN
PA VIA LUIGI ZOJA 30, 20153 MILAN, ITALY
SN 1594-0667
J9 AGING CLIN EXP RES
JI Aging Clin. Exp. Res.
PD FEB
PY 2011
VL 23
IS 1
BP 11
EP 16
DI 10.1007/BF03337742
PG 6
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA 761CE
UT WOS:000290371900003
PM 20065626
DA 2025-06-11
ER

PT J
AU Zhang, X
   Li, ZZ
   Liu, DF
   Xu, X
   Shen, W
   Mei, ZC
AF Zhang, Xia
   Li, Zhongzhuan
   Liu, Dongfang
   Xu, Xin
   Shen, Wei
   Mei, Zhechuan
TI Effects of probucol on hepatic tumor necrosis factor-α, interleukin-6
   and adiponectin receptor-2 expression in diabetic rats
SO JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
LA English
DT Article
DE high fat diet; insulin resistance; non-alcoholic fatty liver disease;
   oxidative stress; probucol
ID NONALCOHOLIC FATTY LIVER; INDUCED INSULIN-RESISTANCE; METABOLIC
   SYNDROME; TNF-ALPHA; STEATOHEPATITIS; HORMONE; OBESITY; INHIBITION;
   DISEASES; GLUCOSE
AB Probucol is a lipid-lowering agent with anti-oxidant effects. Oxidative stress and inflammation are important in the pathophysiology of insulin resistance. We aimed to evaluate the effects of probucol on liver histological changes, serum and hepatic levels of adipokines in rats with high fat-induced type 2 diabetes (T2D).
   Thirty-six rats were divided into a normal control group, a high fat-induced T2D group and a probucol treatment group. After six weeks of treatment with probucol, we evaluated liver histological changes and measured homeostasis model assessment index (HOMA-IR), serum superoxide dismutase (SOD), alanine aminotransferase (ALT), aspartate aminotransferase (AST), tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, adiponectin and hepatic TNF-alpha, IL-6 and adiponectin receptor-2 (adipoR2) mRNA.
   The degree of hepatic steatosis and inflammation, HOMA-IR, serum ALT, TNF-alpha and IL-6 concentrations, and hepatic TNF-alpha and IL-6 mRNA expression in diabetic rats were significantly higher compared with normal controls. Serum SOD and adiponectin concentrations and hepatic adipoR2 mRNA expression in diabetic rats were significantly lower compared with normal controls. Probucol significantly reduced the degree of hepatic steatosis, HOMA-IR, serum ALT, TNF-alpha and IL-6 concentrations, and hepatic TNF-alpha and IL-6 mRNA expression. Probucol significantly raised serum SOD and adiponectin concentrations and hepatic adipoR2 mRNA expression.
   In rats with high fat-induced T2D, treatment with probucol improved insulin sensitivity, hepatic steatosis by raising circulating adiponectin and hepatic adipoR2 levels, in addition to reducing pro-inflammatory cytokines in the circulation and liver.
C1 [Zhang, Xia; Li, Zhongzhuan; Shen, Wei; Mei, Zhechuan] Chongqing Med Univ, Affiliated Hosp 2, Dept Gastroenterol & Hepatol, Chongqing 400010, Peoples R China.
   [Liu, Dongfang; Xu, Xin] Chongqing Med Univ, Affiliated Hosp 2, Dept Endocrinol, Chongqing 400010, Peoples R China.
C3 Chongqing Medical University; Chongqing Medical University
RP Zhang, X (corresponding author), Chongqing Med Univ, Affiliated Hosp 2, Dept Gastroenterol & Hepatol, 76 Linjiang Rd, Chongqing 400010, Peoples R China.
EM sunnyzhangx@gmail.com
RI Shen, Wei/AFL-4859-2022
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NR 35
TC 13
Z9 16
U1 0
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0815-9319
EI 1440-1746
J9 J GASTROEN HEPATOL
JI J. Gastroenterol. Hepatol.
PD JUN
PY 2009
VL 24
IS 6
BP 1058
EP 1063
DI 10.1111/j.1440-1746.2008.05719.x
PG 6
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 451IX
UT WOS:000266465000022
PM 19220660
DA 2025-06-11
ER

PT J
AU Kontush, A
   Chapman, MJ
AF Kontush, A
   Chapman, MJ
TI Antiatherogenic small, dense HDL - guardian angel of the arterial wall?
SO NATURE CLINICAL PRACTICE CARDIOVASCULAR MEDICINE
LA English
DT Review
DE cardiovascular disease; HDL; inflammation; oxidative stress; small dense
   HDL
ID APOLIPOPROTEIN-A-I; ESTER TRANSFER PROTEIN; ELEVATED OXIDATIVE STRESS;
   SERUM-AMYLOID-A; REVERSE CHOLESTEROL TRANSPORT; RANDOMIZED
   CONTROLLED-TRIAL; EXTENDED-RELEASE NIACIN; E-NULL MICE; B TYPE-I;
   LIPOPROTEIN CHOLESTEROL
AB Our understanding of the relationship between the atheroprotective activities of HDL and heterogeneity of HDL particles has advanced greatly. HDL particles are highly heterogeneous in structure, intravascular metabolism and antiatherogenic activity. In this review, we discuss new findings on the antiatherogenic properties of HDL particles. Small, dense HDL possesses potent antioxidative activity but this is compromised under conditions of atherogenic dyslipidemia. HDL functional deficiency frequently coincides with reductions in HDL-cholesterol concentration and alterations in HDL metabolism and structure. Formation of small, dense HDL particles with attenuated antiatherogenic activity can be mechanistically related to HDL enrichment in triglycerides and in serum amyloid A, depletion of cholesteryl esters, covalent modification of HDL apolipoproteins and attenuated antiatherogenic function of apolipoprotein AI. Low circulating levels of HDL cholesterol might, therefore, be associated with the defective functionality of small HDL particles of abnormal structure and composition. In common metabolic diseases, such as type 2 diabetes and metabolic syndrome, deficiency of HDL particle number and function favor accelerated atherosclerosis. Therapeutic normalization of the quantity, quality and biological activities of HDL particles thus represents a novel approach to attenuating atherosclerosis in dyslipidemic individuals with metabolic disease. Cholesteryl ester transfer protein inhibitors, nicotinic acid, reconstituted HDL and other HDL-raising agents are being investigated. Induction of selective increase in the circulating concentrations of small, dense HDL3 particles with increased antiatherogenic activity seems especially promising, particularly for therapy of atherogenic dyslipidemia.
C1 INSERM, Natl Inst Hlth & Med Res, Dyslipoproteinemia & Atherosclerosis Res Unit, U551, Paris, France.
C3 Institut National de la Sante et de la Recherche Medicale (Inserm)
RP Hop Pitie, INSERM, U551, Pavillon Benjamin Delessert,83 Blvd Hop, F-75651 Paris 13, France.
EM kontush@chups.jussieu.fr
RI Kontush, Anatol/J-2198-2016; chapman, john/Y-2742-2019
OI Kontush, Anatol/0000-0002-9008-7335
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NR 60
TC 273
Z9 304
U1 0
U2 8
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1743-4297
J9 NAT CLIN PRACT CARD
JI Nat. Clin. Pract. Cardiovasc. Med.
PD MAR
PY 2006
VL 3
IS 3
BP 144
EP 153
DI 10.1038/ncpcardio0500
PG 10
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 014FE
UT WOS:000235463800010
PM 16505860
DA 2025-06-11
ER

PT J
AU Khaksari, M
   Pourali, M
   Talabon, SR
   Navashenaq, JG
   Bashiri, H
   Amiresmaili, S
AF Khaksari, Mohammad
   Pourali, Mohammadreza
   Talabon, Saman Rezaei
   Navashenaq, Jamshid Gholizadeh
   Bashiri, Hamideh
   Amiresmaili, Sedigheh
TI Protective effects of 17-R-estradiol on liver injury: The role of TLR4
   signaling pathway and inflammatory response
SO CYTOKINE
LA English
DT Review
DE 17R-estradiol; TLR4; Liver injury; Estrogen receptors; Pro-inflammatory
   cytokines
ID TOLL-LIKE RECEPTORS; HEPATOCELLULAR-CARCINOMA; OXIDATIVE STRESS;
   HEPATITIS-C; EXPRESSION PATTERNS; INSULIN-RESISTANCE; GENE-EXPRESSION;
   KUPFFER CELLS; ESTROGEN; TRAUMA
AB Liver injury, a major global health issue, stems from various causes such as alcohol consumption, nonalcoholic steatohepatitis, obesity, diabetes, metabolic syndrome, hepatitis, and certain medications. The liver's unique susceptibility to ischemia and hypoxia, coupled with the critical role of the gut-liver axis in inflammation, underscores the need for effective therapeutic interventions. The study highlights E2 ' s interaction with estrogen receptors (ERs) and its modulation of the Toll-like receptor 4 (TLR4) signaling pathway as key mechanisms in mitigating liver injury. Activation of TLR4 leads to the release of pro-inflammatory cytokines and chemokines, exacerbating liver inflammation and injury. E2 down-regulates TLR4 expression, reduces oxidative stress, and inhibits pro-inflammatory cytokines, thereby protecting the liver. Both classic (ER alpha and ERR) and non-classic [G protein-coupled estrogen receptor (GPER)] receptors are influenced by E2. ER alpha is particularly crucial for liver regeneration, preventing liver failure by promoting hepatocyte proliferation. Furthermore, E2 exerts anti-inflammatory, antioxidant, and anti-apoptotic effects by inhibiting cytokines such as IL-6, IL-1R, TNF-alpha, and IL-17, and by reducing lipid peroxidation and free radical damage. The article calls for further clinical research to validate these findings and to develop estrogen-based treatments for liver injuries. Overall, the research emphasizes the significant potential of E2 as a therapeutic agent for liver injuries. It advocates for extensive clinical studies to validate E2 hepatoprotective properties and develop effective estrogen- based treatments.
C1 [Khaksari, Mohammad] Kerman Univ Med Sci, Inst Neuropharmacol, Neuroscince & Endocrinol & Metab Res Ctr, Kerman, Iran.
   [Pourali, Mohammadreza; Talabon, Saman Rezaei] Bam Univ Med Sci, Sch Med, Bam, Iran.
   [Navashenaq, Jamshid Gholizadeh] Bam Univ Med Sci, Noncommunicable Dis Res Ctr, Bam, Iran.
   [Bashiri, Hamideh] Kerman Univ Med Sci, Neurosci Res Ctr, Afzalipour Sch Med, Dept Physiol & Pharmacol,Inst Neuropharmacol, Kerman, Iran.
   [Amiresmaili, Sedigheh] Bam Univ Med Sci, Dept Physiol, Bam, Iran.
C3 Kerman University of Medical Sciences; Kerman University of Medical
   Sciences
RP Amiresmaili, S (corresponding author), Bam Univ Med Sci, Dept Physiol, Bam, Iran.
EM S.amiresmaili@mubam.ac.ir
RI Gholizadeh Navashenaq, Jamshid/AAZ-7785-2020; Haddad,
   Mohammad/AAB-9025-2019; Amiresmaili, Sedigheh/HHZ-0924-2022; Bashiri,
   Hamideh/AAU-2552-2020
FU Research Center of Bam University of Medical Sciences (Bam, Iran)
FX The authors declare that they have no known competing financial
   interests or personal relationships that could have appeared to
   influence the work reported in this paper. This study was supported by
   the Research Center of Bam University of Medical Sciences (Bam, Iran) .
   The ethical committee of this Univer-sity approved the study protocols
   (Ethic code: IR.MUBAM. REC.1401.072) of this University.
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NR 116
TC 3
Z9 3
U1 1
U2 1
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 1043-4666
EI 1096-0023
J9 CYTOKINE
JI Cytokine
PD SEP
PY 2024
VL 181
AR 156686
DI 10.1016/j.cyto.2024.156686
EA JUL 2024
PG 8
WC Biochemistry & Molecular Biology; Cell Biology; Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology; Immunology
GA K8U5X
UT WOS:001346595500001
PM 38991382
DA 2025-06-11
ER

PT J
AU Ortega, E
   Gálvez, I
   Martín-Cordero, L
AF Ortega, Eduardo
   Galvez, Isabel
   Martin-Cordero, Leticia
TI Adrenergic Regulation of Macrophage-Mediated Innate/Inflammatory
   Responses in Obesity and Exercise in this Condition: Role of β2
   Adrenergic Receptors
SO ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS
LA English
DT Review
DE Macrophages; monocytes; beta 2 adrenergic receptors; inflammation;
   cytokines; phagocytosis; obesity; exercise
ID TUMOR-NECROSIS-FACTOR; ADIPOSE-TISSUE MACROPHAGES; ZUCKER RAT MODEL;
   INFLAMMATORY CYTOKINES; ALPHA-ADRENORECEPTOR; INSULIN-RESISTANCE; STRESS
   HORMONES; KAPPA-B; MODULATION; DIET
AB Background: The effects of exercise on the innate/inflammatory immune responses are crucially mediated by catecholamines and adrenoreceptors; and mediations in both stimulatory and anti-inflammatory responses have been attributed to them. Obesity and metabolic syndrome are included among low-grade chronic inflammatory pathologies; particularly because patients have a dysregulation of the inflammatory and stress responses, which can lead to high levels of inflammatory cytokines that induce insulin resistance, contributing to the onset or exacerbation of type 2 diabetes. Macrophages play a crucial role in this obesity-induced inflammation. Although most of the anti-inflammatory effects of catecholamines are mediated by beta adrenergic receptors (particularly beta 2), it is not known whether in altered homeostatic conditions, such as obesity and during exercise, innate/inflammatory responses of macrophages to beta 2 adrenergic stimulation are similar to those in cells of healthy organisms at baseline.
   Objective: This review aims to emphasize that there could be possible different responses to beta 2 adrenergic stimulation in obesity, and exercise in this condition.
   Methods: A revision of the literature based on the hypothesis that obesity affects beta 2 adrenergic regulation of macrophage-mediated innate/inflammatory responses, as well as the effect of exercise in this context.
   Conclusion: The inflammatory responses mediated by beta 2 adrenoreceptors are different in obese individuals with altered inflammatory states at baseline compared to healthy individuals, and exercise can also interfere with these responses. Nevertheless, it is clearly necessary to develop more studies that contribute to widening the knowledge of the neuroimmune regulation process in obesity, particularly in this context.
C1 [Ortega, Eduardo; Galvez, Isabel] Univ Extremadura, Fac Sci, Dept Physiol, Immunophysiol Res Grp, Badajoz, Spain.
   [Martin-Cordero, Leticia] Univ Extremadura, Univ Ctr Plasencia, Dept Nursing, Immunophysiol Res Grp, Plasencia, Spain.
C3 Universidad de Extremadura; Universidad de Extremadura
RP Ortega, E; Gálvez, I (corresponding author), Univ Extremadura, Dept Fisiol, Fac Ciencias, Avda Elvas S-N, E-06071 Badajoz, Spain.
EM orincon@unex.es; igalvez@unex.es
RI Ortega, Eduardo/GXN-2560-2022; Galvez, Isabel/LFS-2823-2024; Ortega,
   Eduardo/H-9891-2016; Martin-Cordero, Leticia/H-9711-2015
OI Galvez, Isabel/0000-0002-4294-4507; Ortega, Eduardo/0000-0002-7007-7615;
   Martin-Cordero, Leticia/0000-0002-3651-2265
FU Ministerio de Economia y Competitividad [DEP2015-66093-R]; Gobierno de
   Extremadura-FEDER; Ministerio de Educacion, Cultura y Deporte, Spain
   [FPU15/02395]
FX This investigation was partially supported by the Ministerio de Economia
   y Competitividad (DEP2015-66093-R) and the Gobierno de
   Extremadura-FEDER. I. Galvez is recipient of a "Formacion del
   Profesorado Universitario (FPU)" predoctoral contract (FPU15/02395) from
   the Ministerio de Educacion, Cultura y Deporte, Spain.
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NR 108
TC 19
Z9 23
U1 1
U2 9
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1871-5303
EI 2212-3873
J9 ENDOCR METAB IMMUNE
JI Endocr. Metab. Immune Disord.-Drug Targets
PY 2019
VL 19
IS 8
BP 1089
EP 1099
DI 10.2174/1871530319666190206124520
PG 11
WC Endocrinology & Metabolism; Immunology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Immunology; Pharmacology & Pharmacy
GA JM9DV
UT WOS:000496507700001
PM 30727934
OA Green Published
DA 2025-06-11
ER

PT J
AU Karim, N
   Jia, ZQ
   Zheng, XD
   Cui, SL
   Chen, W
AF Karim, Naymul
   Jia, Zhenquan
   Zheng, Xiaodong
   Cui, Sunliang
   Chen, Wei
TI A recent review of citrus flavanone naringenin on metabolic diseases and
   its potential sources for high yield-production
SO TRENDS IN FOOD SCIENCE & TECHNOLOGY
LA English
DT Review
DE Naringenin; Metabolic diseases; Antioxidant activity; Potential sources
ID INDUCED OXIDATIVE STRESS; DIET-INDUCED OBESITY; PHENOLIC-COMPOUNDS;
   GRAPEFRUIT JUICE; INDUCED TOXICITY; RAT MODEL; IN-VIVO; INDUCED
   NEPHROTOXICITY; HEPATIC INFLAMMATION; LIPID-PEROXIDATION
AB Background: Metabolic syndromes are the multi-metabolic abnormality characterized by hyperlipidemia, obesity, hyperglycemia, diabetes, hypertension, cardiovascular disease, and neuro-dysfunction. Naringenin, a naturally occurring flavanone compound, abundantly found in citrus fruit, has demonstrated diverse biological activities. In this context, the role of naringenin in the treatment of metabolic disease and alternative sources for high-yield production of naringenin have recently drawn full scientific attention and become an important issue in research.
   Scope and approach: This review focuses on recent findings of naringenin against metabolic disorders including oxidative stress, hyperlipidemia, obesity, diabetes, inflammation, and organ toxicity. Also, this review highlights the potential sources of naringenin production.
   Key findings and conclusions: Naringenin exerts its protective effect against metabolic diseases through multiple mechanisms including its antioxidant activity by scavenging free radicals, inducing antioxidant enzymes and targeting on phosphoinositide 3-kinase/protein Kinase B/nuclear factor (erythroid-derived 2)-like 2 (PI3K/Akt/ Nrf2), nuclear factor (erythroid-derived 2)-like 2/antioxidant responsive element (NRf2/ARE), nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB), mitogen-activated protein kinase (MAPK), 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase, peroxisome proliferator-activated receptor (PPAR), and nitric oxide-cGMP-protein kinase G-induced K-ATP channel (NO-cGMP-PKG-K-ATP). Moreover, microbial production is recommended as a promising alternative method for large-scale production of naringenin. In conclusion, naringenin is a promising compound for the prevention and management of metabolic diseases. Further clinical studies and trials are needed to prove its protective effects on metabolic syndrome in the human population.
C1 [Karim, Naymul; Zheng, Xiaodong; Chen, Wei] Zhejiang Univ, Natl Engn Lab Intelligent Food Technol & Equipmen, Dept Food Sci & Nutr,Zhejiang Key Lab Agrofood Pr, Key Lab Agroprod Postharvest Handling,Minist Agr, Hangzhou 310058, Zhejiang, Peoples R China.
   [Cui, Sunliang] Zhejiang Univ, Inst Drug Discovery & Design, Coll Pharmaceut Sci, Hangzhou 310058, Zhejiang, Peoples R China.
   [Jia, Zhenquan] Univ North Carolina Greensboro, Dept Biol, Greensboro, NC 27412 USA.
C3 Ministry of Agriculture & Rural Affairs; Zhejiang University; Zhejiang
   University; University of North Carolina; University of North Carolina
   Greensboro
RP Cui, SL (corresponding author), Zhejiang Univ, Inst Drug Discovery & Design, Coll Pharmaceut Sci, Hangzhou 310058, Zhejiang, Peoples R China.; Chen, W (corresponding author), Zhejiang Univ, Dept Food Sci & Nutr, 866 Yuhangtang Rd, Hangzhou 310058, Zhejiang, Peoples R China.
EM slcui@zju.edu.cn; zjuchenwei@zju.edu.cn
RI zheng, xiaodong/C-4050-2008; Chen, Wei/AAR-9817-2020; Karim,
   Naymul/K-9547-2018; Cui, Sunliang/F-8232-2011; Karim,
   Naymul/IIS-9600-2023
OI CHEN, WEI/0000-0002-2373-2437; Karim, Naymul/0000-0002-6515-0611
FU Zhejiang Provincial Natural Science Foundation of China [LR18C200002];
   National Natural Science Foundation of China [U1703105]; Fundamental
   Research Funds for the Central Universities [2017QNA6006]
FX This work was supported by Grants from Zhejiang Provincial Natural
   Science Foundation of China (LR18C200002), National Natural Science
   Foundation of China (U1703105), and the Fundamental Research Funds for
   the Central Universities (2017QNA6006).
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NR 165
TC 96
Z9 102
U1 7
U2 114
PU ELSEVIER SCIENCE LONDON
PI LONDON
PA 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND
SN 0924-2244
EI 1879-3053
J9 TRENDS FOOD SCI TECH
JI Trends Food Sci. Technol.
PD SEP
PY 2018
VL 79
BP 35
EP 54
DI 10.1016/j.tifs.2018.06.012
PG 20
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA GR8KZ
UT WOS:000442974100005
DA 2025-06-11
ER

PT J
AU Ergaz, Z
   Weinstein-Fudim, L
   Ornoy, A
AF Ergaz, Zivanit
   Weinstein-Fudim, Liza
   Ornoy, Asher
TI High sucrose low copper diet in pregnant diabetic rats induces transient
   oxidative stress, hypoxia, and apoptosis in the offspring's liver
SO BIRTH DEFECTS RESEARCH
LA English
DT Article
DE rat offspring; diabetes; pregnancy; redox status; liver
ID NF-KAPPA-B; DNA METHYLATION; PANCREATIC DAMAGE; GENE-EXPRESSION;
   FETAL-GROWTH; HYPERGLYCEMIA; DEFICIENCY; MECHANISM; EMBRYOS; MODEL
AB Background: Hyperglycemia-related oxidative stress and hypoxia are important mechanisms responsible for diabetes-induced embryopathy and other complications. High sucrose low copper diet (HSD), but not regular diet (RD), induces type 2 diabetes in the inbred Cohen diabetic sensitive (CDs) rats but not in the Sabra control rats. We recently demonstrated long-term changes of DNA methylation and gene expression in various groups of genes, including genes involved in oxidant-antioxidant activity in the liver of 2-4-week-old CDs offspring of diabetic dams. We now studied the postnatal effects of diabetes and/or HSD on several liver metabolic parameters in these offspring.
   Methods: we studied lipid peroxidation, activity of the antioxidants enzymes superoxide dismutase (SOD) and Catalase (CAT). By immunohistochemistry: protein oxidation by nitrotyrosine staining, hypoxia inducing factor1 alpha (HIF1 alpha), apoptosis [caspase 3, bcl-2-like protein (BAX)], proliferation [proliferating cell nuclear antigen (PCNA)] and NF-kappa B.
   Results: In the Sabra rats fed HSD only few, early and transitional changes were observed in lipid peroxidation, SOD and CAT activity. In the CDs fed HSD more significant changes in lipid and protein oxidation, HIF1 alpha, apoptosis and proliferation were observed, persisting for longer.
   Conclusions: The changes in the Sabra rats HSD were attributed to the pro-oxidant effects of the diet and those in the diabetic CDs to the HSD and maternal diabetes. In light of the DNA methylation changes in the liver of the CDs HSD, we presume that changes in gene expression are responsible for our findings, and that similar changes may lead to the metabolic syndrome at adulthood.
C1 [Ergaz, Zivanit] Hadassah Hebrew Univ, Med Ctr, Neonatol, Jerusalem, Israel.
   [Ergaz, Zivanit; Weinstein-Fudim, Liza; Ornoy, Asher] Hebrew Univ Jerusalem, Hadassah Med Sch, Dept Med Neurobiol, Lab Teratol, Jerusalem, Israel.
C3 Hebrew University of Jerusalem; Hadassah University Medical Center;
   Hebrew University of Jerusalem
RP Ergaz, Z (corresponding author), Hadassah Hebrew Univ Hosp, Jerusalem, Israel.
EM zivanit@hadassah.org.il
RI Ornoy, Asher/J-8038-2018
OI Ornoy, Asher/0000-0002-7268-3512
FU U.S.-Israel Binational Science Foundation (BSF) [0374352]; Israel
   Science Foundation (ISF) [0394193]
FX This study was supported in part by grant 0374352 from the The
   U.S.-Israel Binational Science Foundation (BSF) and by grant 0394193
   from the Israel Science Foundation (ISF)
CR [Anonymous], COHEN DIABETIC RAT
   [Anonymous], OPEN J ENDOCRINE MET
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NR 41
TC 1
Z9 1
U1 0
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2472-1727
J9 BIRTH DEFECTS RES
JI Birth Defects Res.
PD JUL 17
PY 2018
VL 110
IS 12
BP 1001
EP 1015
DI 10.1002/bdr2.1341
PG 15
WC Developmental Biology; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Developmental Biology; Toxicology
GA GU8YT
UT WOS:000445630800005
PM 29851303
DA 2025-06-11
ER

PT J
AU Pereira, ENGD
   Silvares, RR
   Flores, EEI
   Rodrigues, KL
   Ramos, IP
   da Silva, IJ
   Machado, MP
   Miranda, RA
   Pazos-Moura, CC
   Gonçalves-de-Albuquerque, CF
   Faria-Neto, HCD
   Tibiriça, E
   Daliry, A
AF Goulart da Silva Pereira, Evelyn Nunes
   Silvares, Raquel Rangel
   Ilaquita Flores, Edgar Eduardo
   Rodrigues, Karine Lino
   Ramos, Isalira Peroba
   da Silva, Igor Josea
   Machado, Marcelo Pelajo
   Miranda, Rosiane Aparecida
   Pazos-Moura, Carmen Cabanelas
   Goncalves-de-Albuquerque, Cassiano F.
   de Castro Faria-Neto, Hugo Caire
   Tibirica, Eduardo
   Daliry, Anissa
TI Hepatic microvascular dysfunction and increased advanced glycation end
   products are components of non-alcoholic fatty liver disease
SO PLOS ONE
LA English
DT Article
ID METABOLIC SYNDROME; ENDOTHELIAL DYSFUNCTION; CARDIOVASCULAR-DISEASE;
   INFLAMMATORY RESPONSE; ELEVATED LEVELS; MICROCIRCULATION;
   STEATOHEPATITIS; PROGRESSION; MODEL; PATHOGENESIS
AB Background
   This study aimed to investigate the pathophysiology of hepatic microcirculatory dysfunction in non-alcoholic fatty liver disease (NAFLD).
   Methods
   In Wistar rats, NAFLD model was induced by 20 weeks of high-fat diet (HFD) feeding. Rolling and adhesion of leukocytes and tissue perfusion in hepatic microcirculation were examined using in vivo microscopic and laser speckle contrast imaging (LSCI), respectively. Oxidative stress and inflamatory parameters were analysed by TBARs, catalase enzyme activity, RT-PCR and ELISA. The participation of advanced glycation end-products (AGE) and its receptor RAGE was evaluated by the measurement of gene and protein expression of RAGE by RT-PCR and Western-blot, respectively and by liver and serum quantification of fluorescent AGEs.
   Results
   Wistar rats fed high-fat diet (HFD) showed increase in epididymal and abdominal fat content, systolic arterial blood pressure, fasting blood glucose levels, hepatic triglycerides and cholesterol, and impairment of glucose and insulin metabolisms. Liver histology confirmed the presence of steatosis and ultrasound analysis revealed increased liver size and parenchymal echogenicity in HFD-fed rats. HFD causes significant increases in leukocyte rolling and adhesion on hepatic microcirculation and decrease in liver microvascular blood flow. Liver tissue presented increase in oxidative stress and inflammtion. At 20 weeks, there was a significantly increase in AGE content in the liver and serum of HFD-fed rats and an increase in RAGE gene expression in the liver.
   Conclusion
   The increase in liver AGE levels and microcirculatory disturbances could play a role in the pathogenesis of liver injury and are key components of NAFLD.
C1 [Goulart da Silva Pereira, Evelyn Nunes; Silvares, Raquel Rangel; Ilaquita Flores, Edgar Eduardo; Rodrigues, Karine Lino; Tibirica, Eduardo; Daliry, Anissa] Oswaldo Cruz Inst, Lab Cardiovasc Invest, Rio De Janeiro, RJ, Brazil.
   [Ramos, Isalira Peroba] Univ Fed Rio de Janeiro, Lab Celular & Mol Cardiol, Rio De Janeiro, RJ, Brazil.
   [Ramos, Isalira Peroba] Univ Fed Rio de Janeiro, Natl Ctr Struct Biol & Bioimaging, Rio De Janeiro, RJ, Brazil.
   [da Silva, Igor Josea; Machado, Marcelo Pelajo] Oswaldo Cruz Inst, Lab Pathol, Rio De Janeiro, RJ, Brazil.
   [Miranda, Rosiane Aparecida; Pazos-Moura, Carmen Cabanelas] Univ Fed Rio de Janeiro, Lab Mol Endocrinol, Rio De Janeiro, RJ, Brazil.
   [Goncalves-de-Albuquerque, Cassiano F.; de Castro Faria-Neto, Hugo Caire] Oswaldo Cruz Inst, Lab Immunopharmacol, Rio De Janeiro, RJ, Brazil.
C3 Fundacao Oswaldo Cruz; Universidade Federal do Rio de Janeiro;
   Universidade Federal do Rio de Janeiro; Fundacao Oswaldo Cruz;
   Universidade Federal do Rio de Janeiro; Fundacao Oswaldo Cruz
RP Daliry, A (corresponding author), Oswaldo Cruz Inst, Lab Cardiovasc Invest, Rio De Janeiro, RJ, Brazil.
EM daliry@gmail.com
RI Moura, Carmen/M-9256-2014; Daliry, Anissa/F-6256-2014; Machado,
   Marcelo/I-5359-2012; Miranda, Rosiane Aparecida/C-1688-2019;
   Goncalves-de-Albuquerque, Cassiano Felippe/N-2815-2014; Nunes Goulart da
   Silva Pereira, Evelyn/AAG-2711-2021
OI Miranda, Rosiane Aparecida/0000-0003-0978-7949; Daliry,
   Anissa/0000-0001-7303-0030; Pelajo Machado, Marcelo/0000-0002-7295-7018;
   Peroba Rezende Ramos, Isalira/0000-0003-3577-0403;
   Goncalves-de-Albuquerque, Cassiano Felippe/0000-0002-4458-3055; Nunes
   Goulart da Silva Pereira, Evelyn/0000-0001-5511-7036
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NR 55
TC 42
Z9 45
U1 0
U2 12
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JUN 19
PY 2017
VL 12
IS 6
AR e0179654
DI 10.1371/journal.pone.0179654
PG 20
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA EY5TN
UT WOS:000404043100043
PM 28628674
OA gold, Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Sumis, A
   Cook, KL
   Andrade, FO
   Hu, R
   Kidney, E
   Zhang, XY
   Kim, D
   Carney, E
   Nguyen, N
   Yu, W
   Bouker, KB
   Cruz, I
   Clarke, R
   Hilakivi-Clarke, L
AF Sumis, Allison
   Cook, Katherine L.
   Andrade, Fabia O.
   Hu, Rong
   Kidney, Emma
   Zhang, Xiyuan
   Kim, Dominic
   Carney, Elissa
   Nguyen Nguyen
   Yu, Wei
   Bouker, Kerrie B.
   Cruz, Idalia
   Clarke, Robert
   Hilakivi-Clarke, Leena
TI Social isolation induces autophagy in the mouse mammary gland: link to
   increased mammary cancer risk
SO ENDOCRINE-RELATED CANCER
LA English
DT Article
DE breast cancer; social isolation; autophagy
ID POSTTRAUMATIC-STRESS-DISORDER; ENDOPLASMIC-RETICULUM STRESS;
   BREAST-CANCER; NEUROPEPTIDE-Y; GENE-EXPRESSION; ADIPOSE-TISSUE;
   PPAR-GAMMA; METABOLIC SYNDROME; TUMOR-GROWTH; OBESITY
AB Social isolation is a strong predictor of early all-cause mortality and consistently increases breast cancer risk in both women and animal models. Because social isolation increases body weight, we compared its effects to those caused by a consumption of obesity-inducing diet (OID) in C57BL/6 mice. Social isolation and OID impaired insulin and glucose sensitivity. In socially isolated, OID-fed mice (I-OID), insulin resistance was linked to reduced Pparg expression and increased neuropeptide Y levels, but in group-housed OID fed mice (G-OID), it was linked to increased leptin and reduced adiponectin levels, indicating that the pathways leading to insulin resistance are different. Carcinogen-induced mammary tumorigenesis was significantly higher in I-OID mice than in the other groups, but cancer risk was also increased in socially isolated, control diet-fed mice (I-C) and G-OID mice compared with that in controls. Unfolded protein response (UPR) signaling (GRP78; IRE1) was upregulated in the mammary glands of OID-fed mice, but not in control diet-fed, socially isolated I-C mice. In contrast, expression of BECLIN1, ATG7 and LC3II were increased, and p62 was downregulated by social isolation, indicating increased autophagy. In the mammary glands of socially isolated mice, but not in G-OID mice, mRNA expressions of p53 and the p53-regulated autophagy inducer Dram1 were upregulated, and nuclear p53 staining was strong. Our findings further indicated that autophagy and tumorigenesis were not increased in Atg7+/- mice kept in social isolation and fed OID. Thus, social isolation may increase breast cancer risk by inducing autophagy, independent of changes in body weight.
C1 [Sumis, Allison; Cook, Katherine L.; Andrade, Fabia O.; Hu, Rong; Kidney, Emma; Zhang, Xiyuan; Kim, Dominic; Carney, Elissa; Nguyen Nguyen; Yu, Wei; Bouker, Kerrie B.; Cruz, Idalia; Clarke, Robert; Hilakivi-Clarke, Leena] Georgetown Univ, Dept Oncol, Washington, DC 20057 USA.
   [Cook, Katherine L.] Wake Forest Univ, Dept Surg, Winston Salem, NC 27109 USA.
   [Andrade, Fabia O.] Univ Sao Paulo, Dept Food & Expt Nutr, Fac Pharmaceut Sci, Sao Paulo, Brazil.
C3 Georgetown University; Wake Forest University; Universidade de Sao Paulo
RP Hilakivi-Clarke, L (corresponding author), Georgetown Univ, Dept Oncol, Washington, DC 20057 USA.
EM clarkel@georgetown.edu
RI Clarke, Robert/A-6485-2008
OI Clarke, Robert/0000-0002-9278-0854; Cook, Katherine/0000-0001-6241-0214
FU National Cancer Institute [P30-CA51008, RO1-CA164384, U54-CA149147];
   National Cancer Institute [P30CA046592] Funding Source: NIH RePORTER
FX This work was supported by the National Cancer Institute (P30-CA51008,
   RO1-CA164384, U54-CA149147).
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NR 97
TC 16
Z9 17
U1 0
U2 13
PU BIOSCIENTIFICA LTD
PI BRISTOL
PA EURO HOUSE, 22 APEX COURT WOODLANDS, BRADLEY STOKE, BRISTOL BS32 4JT,
   ENGLAND
SN 1351-0088
EI 1479-6821
J9 ENDOCR-RELAT CANCER
JI Endocr.-Relat. Cancer
PD OCT
PY 2016
VL 23
IS 10
BP 839
EP 856
DI 10.1530/ERC-16-0359
PG 18
WC Oncology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Oncology; Endocrinology & Metabolism
GA EB7WV
UT WOS:000387602700017
PM 27550962
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Kawamoto, R
   Ninomiya, D
   Kasai, Y
   Kusunoki, T
   Ohtsuka, N
   Kumagi, T
   Abe, M
AF Kawamoto, Ryuichi
   Ninomiya, Daisuke
   Kasai, Yoshihisa
   Kusunoki, Tomo
   Ohtsuka, Nobuyuki
   Kumagi, Teru
   Abe, Masanori
TI Serum Uric Acid Is Positively Associated with Handgrip Strength among
   Japanese Community-Dwelling Elderly Women
SO PLOS ONE
LA English
DT Article
ID C-REACTIVE PROTEIN; INDUCED OXIDATIVE STRESS; J-SHAPED ASSOCIATION;
   OLDER PERSONS; METABOLIC SYNDROME; MUSCLE STRENGTH; INFLAMMATORY
   MARKERS; PHYSICAL FUNCTION; BLOOD-PRESSURE; ALL-CAUSE
AB Serum uric acid (UA) has strong anti-oxidant properties. Muscle strength and mass decrease with age, and recently, this decrease has been defined as sarcopenia. Sarcopenia may be triggered by oxidative stress. We investigated whether serum UA is associated with handgrip strength (HGS), which is a useful indicator of sarcopenia, among Japanese community-dwelling elderly persons. The present study included 602 men aged 72 +/- 7 years and 847 women aged 71 +/- 6 years from a rural village. We examined the cross-sectional relationship between serum UA and HGS. In both genders, HGS increased significantly with increased serum UA levels. A multiple linear regression analysis using HGS as an objective variable and various confounding factors as explanatory variables showed that in men age, drinking status, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and estimated glomerular filtration ratio (eGFR(CKDEPI)) were independently and significantly associated with HGS, and in women, serum UA as well as age, body mass index, drinking status, diastolic blood pressure, and eGFR(CKDEPI) were independently and significantly associated with HGS. In women, age and multivariate-adjusted HGS were significantly higher in the Quartile-3 (4.8-5.4 mg/dL) and Quartile-4 groups (5.5-9.3 mg/dL) of serum UA than in the lower groups (0.7-4.7 mg/dL). These results suggest that serum UA may have a protective role in aging-associated decline in muscle strength in community-dwelling elderly women.
C1 [Kawamoto, Ryuichi; Ninomiya, Daisuke; Kumagi, Teru; Abe, Masanori] Ehime Univ, Grad Sch Med, Dept Community Med, Matsuyama, Ehime 7910295, Japan.
   [Kawamoto, Ryuichi; Ninomiya, Daisuke; Kasai, Yoshihisa; Kusunoki, Tomo; Ohtsuka, Nobuyuki] Seiyo Municipal Nomura Hosp, Dept Internal Med, Matsuyama, Ehime 7971212, Japan.
C3 Ehime University
RP Kawamoto, R (corresponding author), Ehime Univ, Grad Sch Med, Dept Community Med, Matsuyama, Ehime 7910295, Japan.; Kawamoto, R (corresponding author), Seiyo Municipal Nomura Hosp, Dept Internal Med, Matsuyama, Ehime 7971212, Japan.
EM rykawamo@m.ehime-u.ac.jp
RI Kumagi, Teru/AAS-7427-2021
OI Kumagi, Teru/0000-0002-2292-7750
FU Foundation for Development of Community
FX This work was supported in part by a grant-in-aid for Scientific
   Research from the Foundation for Development of Community (2014). No
   additional external funding was received for this study. The funders had
   no role in study design, data collection and analysis, decision to
   publish, or preparation of the manuscript.
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NR 38
TC 35
Z9 37
U1 0
U2 5
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD APR 14
PY 2016
VL 11
IS 4
AR e0151044
DI 10.1371/journal.pone.0151044
PG 12
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA DJ3UH
UT WOS:000374131700002
PM 27078883
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Lynch, CM
   Kinzenbaw, DA
   Chen, XX
   Zhan, SS
   Mezzetti, E
   Filosa, J
   Ergul, A
   Faulkner, JL
   Faraci, FM
   Didion, SP
AF Lynch, Cynthia M.
   Kinzenbaw, Dale A.
   Chen, Xunxheng
   Zhan, Shanshan
   Mezzetti, Erin
   Filosa, Jessica
   Ergul, Adviye
   Faulkner, Jessica L.
   Faraci, Frank M.
   Didion, Sean P.
TI Nox2-Derived Superoxide Contributes to Cerebral Vascular Dysfunction in
   Diet-Induced Obesity
SO STROKE
LA English
DT Article
DE brain; diabetes mellitus; type 2; diet; high-fat; oxidative stress
ID ENDOTHELIUM-DEPENDENT RESPONSES; E-DEFICIENT MICE; HIGH-FAT DIET;
   OXIDATIVE STRESS; ANGIOTENSIN-II; NITRIC-OXIDE; HYPERLIPIDEMIC MICE;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; INDUCED IMPAIRMENT
AB Background and Purpose Obesity is an increasing epidemic worldwide; however, little is known about effects of obesity produced by high-fat diet (HFD) on the cerebral circulation. The purpose of this study was to examine the functional and temporal effects of a HFD on carotid and cerebral vascular function and to identify mechanisms that contribute to such functional alterations.
   Methods Responses of cerebral arterioles (in vivo) and carotid arteries (in vitro) were examined in C57Bl/6 (wild-type) and Nox2-deficient (Nox2(-/-)) mice fed a control (10%) or a HFD (45% or 60% kcal of fat) for 8, 12, 30, or 36 weeks.
   Results In wild-type mice, a HFD produced obesity and endothelial dysfunction by 12 and 36 weeks in cerebral arterioles and carotid arteries, respectively. Endothelial function could be significantly improved with Tempol (a superoxide scavenger) treatment in wild-type mice fed a HFD. Despite producing a similar degree of obesity in both wild-type and Nox2(-/-) mice, endothelial dysfunction was observed only in wild-type, but not in Nox2(-/-), mice fed a HFD.
   Conclusions Endothelial dysfunction produced by a HFD occurs in a temporal manner and appears much earlier in cerebral arterioles than in carotid arteries. Genetic studies revealed that Nox2-derived superoxide plays a major role in endothelial dysfunction produced by a HFD. Such functional changes may serve to predispose blood vessels to reduced vasodilator responses and thus may contribute to alterations in cerebral blood flow associated with obesity.
C1 [Lynch, Cynthia M.; Kinzenbaw, Dale A.; Faraci, Frank M.] Univ Iowa, Dept Internal Med, Carver Coll Med, Iowa City, IA 52242 USA.
   [Faraci, Frank M.] Univ Iowa, Dept Pharmacol, Carver Coll Med, Iowa City, IA 52242 USA.
   [Chen, Xunxheng; Mezzetti, Erin] Georgia Regents Univ, Vasc Biol Ctr, Augusta, GA USA.
   [Filosa, Jessica; Ergul, Adviye] Georgia Regents Univ, Dept Physiol, Med Coll Georgia, Augusta, GA USA.
   [Zhan, Shanshan; Faulkner, Jessica L.; Didion, Sean P.] Univ Mississippi, Med Ctr, Dept Pharmacol, Jackson, MS 39216 USA.
   [Didion, Sean P.] Univ Mississippi, Med Ctr, Dept Neurol, Jackson, MS 39216 USA.
   [Ergul, Adviye] Charlie Norwood VA Med Ctr, Augusta, GA USA.
C3 University of Iowa; University of Iowa; University System of Georgia;
   Augusta University; University System of Georgia; Augusta University;
   University of Mississippi; University of Mississippi Medical Center;
   University of Mississippi; University of Mississippi Medical Center; US
   Department of Veterans Affairs; Veterans Health Administration (VHA);
   Charlie Norwood VA Medical Center
RP Didion, SP (corresponding author), Univ Mississippi, Med Ctr, Dept Pharmacol, Arthur C Guyton Lab Res Bldg,G311-313,2500 N Stat, Jackson, MS 39216 USA.
EM didionlab@gmail.com
RI Filosa, Jessica/ABG-4524-2020
OI Faraci, Frank/0000-0002-0203-1690; Faulkner, Jessica/0000-0003-3362-412X
FU National Institutes of Health [HL-089884, HL-107632, NS-24621, HL-62984,
   HL-089067, NS-054688]; American Heart Association [EIA-0740002N];
   Veterans Affairs Merit grant [BX000347]; Georgia Health Sciences
   University's Diabetes and Obesity Discovery Institute
FX This study was supported by National Institutes of Health grants
   HL-089884 and HL-107632 (to Dr Didion), NS-24621 and HL-62984 (to Dr
   Faraci), HL-089067 (to Dr Filosa), NS-054688 (to Dr Ergul), American
   Heart Association grant (EIA-0740002N to Dr Ergul), and Veterans Affairs
   Merit grant (BX000347 to Dr Ergul). This study was also supported in
   part by a Synergy Award from the Georgia Health Sciences University's
   Diabetes and Obesity Discovery Institute (to Drs Ergul, Filosa, and
   Didion).
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NR 49
TC 68
Z9 69
U1 0
U2 11
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0039-2499
EI 1524-4628
J9 STROKE
JI Stroke
PD NOV
PY 2013
VL 44
IS 11
BP 3195
EP 3201
DI 10.1161/STROKEAHA.113.001366
PG 7
WC Clinical Neurology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Cardiovascular System & Cardiology
GA 238YE
UT WOS:000325987300053
PM 24072007
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Kanczkowski, W
   Ziegler, CG
   Zacharowski, K
   Bornstein, SR
AF Kanczkowski, W.
   Ziegler, C. G.
   Zacharowski, K.
   Bornstein, S. R.
TI Toll-like receptors in endocrine disease and diabetes
SO NEUROIMMUNOMODULATION
LA English
DT Article
DE stress; hypothalamic-pituitary-adrenal axis; proinflammatory cytokines;
   insulin resistance; obesity; pattern recognition receptors
ID INTERLEUKIN-6 PRODUCTION; AUTOIMMUNE-THYROIDITIS; NONTHYROIDAL ILLNESS;
   INSULIN-RESISTANCE; IMMUNE; CELLS; LIPOPOLYSACCHARIDE; EXPRESSION;
   INFLAMMATION; PATHWAYS
AB The body's ability to keep a steady homeostatic state is crucial to health and life. This involves providing an adequate response to a variety of challenges both physical and mental, such as microbial invasion and emotional distress. Interplay between the neuroendocrine and immune systems is essential in either case. Studies have demonstrated that toll-like receptors, or TLRs, play a regulatory role in both systems, and have been proposed as a possible link between the immune, hormonal and metabolic systems. As part of the innate immune system, these receptors control the identification by the body of microbial invaders and its immediate reaction in immune and inflammatory response. What are referred to as pattern recognition receptors are mostly expressed by cells involved in hematopoietic linkage, but an increasing number of studies have demonstrated their expression in other cell types such as neurons and endocrine cells on the hypothalamic-pituitary-adrenal (HPA) axis, thyrocytes, adipocytes and islets of Langerhans. Together with endocrine and metabolic dysregulation, immune system overreaction is often associated with infection and autoimmunity, clearly indicating TLR involvement at organ level which affects organ function. Several diseases such as autoimmune thyroid and pancreatic diseases, septic dysregulation of the HPA axis, diabetes and the metabolic syndrome have been linked to TLR activation and polymorphism. To gain insight into stress response and adaptation, we need to know more about TLRs and the specific physiological role they play in the endocrine and metabolic system and its processes. Copyright (C) 2008 S. Karger AG, Basel.
C1 [Zacharowski, K.] Bristol Royal Infirm & Gen Hosp, Mol Cardioprotect & Inflammat Grp, Bristol, England.
   Carl Gustav Carus Univ Hosp, Dept Med 3, Dresden, Germany.
C3 Bristol Royal Infirmary; Technische Universitat Dresden; Carl Gustav
   Carus University Hospital
RP Bornstein, SR (corresponding author), Tech Univ Dresden, Carl Gustav Carus Med Sch, Dept Med 3, Fetscherstr 74, DE-01307 Dresden, Germany.
EM Stefan.Bornstein@uniklinikum-dresden.de
OI Kanczkowski, Waldemar/0000-0002-5595-8393
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NR 47
TC 28
Z9 32
U1 0
U2 2
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1021-7401
J9 NEUROIMMUNOMODULAT
JI Neuroimmunomodulation
PY 2008
VL 15
IS 1
BP 54
EP 60
DI 10.1159/000135624
PG 7
WC Endocrinology & Metabolism; Immunology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Immunology; Neurosciences & Neurology
GA 334ME
UT WOS:000258225100007
PM 18667800
DA 2025-06-11
ER

PT J
AU Potenza, MA
   Iacobazzi, D
   Sgarra, L
   Montagnani, M
AF Potenza, Maria Assunta
   Iacobazzi, Dominga
   Sgarra, Luca
   Montagnani, Monica
TI The Intrinsic Virtues of EGCG, anExtremely Good Cell Guardian, on
   Prevention and Treatment of Diabesity Complications
SO MOLECULES
LA English
DT Review
DE epigallocatechin-3-gallate (EGCG); oxidative stress; diabetes; obesity;
   redox balance
ID GREEN TEA POLYPHENOL; TYPE-2 DIABETES-MELLITUS; NITRIC-OXIDE SYNTHASE;
   DIET-INDUCED OBESITY; COLON-CANCER CELLS; HIGH-FAT DIET;
   EPIGALLOCATECHIN GALLATE; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   OXIDATIVE STRESS
AB The pandemic proportion of diabesity-a combination of obesity and diabetes-sets a worldwide health issue. Experimental and clinical studies have progressively reinforced the pioneering epidemiological observation of an inverse relationship between consumption of polyphenol-rich nutraceutical agents and mortality from cardiovascular and metabolic diseases. With chemical identification of epigallocatechin-3-gallate (EGCG) as the most abundant catechin of green tea, a number of cellular and molecular mechanisms underlying the activities of this unique catechin have been proposed. Favorable effects of EGCG have been initially attributed to its scavenging effects on free radicals, inhibition of ROS-generating mechanisms and upregulation of antioxidant enzymes. Biologic actions of EGCG are concentration-dependent and under certain conditions EGCG may exert pro-oxidant activities, including generation of free radicals. The discovery of 67-kDa laminin as potential EGCG membrane target has broaden the likelihood that EGCG may function not only because of its highly reactive nature, but also via receptor-mediated activation of multiple signaling pathways involved in cell proliferation, angiogenesis and apoptosis. Finally, by acting as epigenetic modulator of DNA methylation and chromatin remodeling, EGCG may alter gene expression and modify miRNA activities. Despite unceasing research providing detailed insights, ECGC composite activities are still not completely understood. This review summarizes the most recent evidence on molecular mechanisms by which EGCG may activate signal transduction pathways, regulate transcription factors or promote epigenetic changes that may contribute to prevent pathologic processes involved in diabesity and its cardiovascular complications.
C1 [Potenza, Maria Assunta; Sgarra, Luca; Montagnani, Monica] Univ Bari Aldo Moro, Dept Biomed Sci & Human Oncol, I-70124 Bari, Italy.
   [Iacobazzi, Dominga] Univ Bristol, Bristol Med Sch, Fac Hlth Sci, Bristol BS8 1QU, Avon, England.
C3 Universita degli Studi di Bari Aldo Moro; University of Bristol
RP Potenza, MA; Montagnani, M (corresponding author), Univ Bari Aldo Moro, Dept Biomed Sci & Human Oncol, I-70124 Bari, Italy.
EM mariaassunta.potenza@uniba.it; domingaiacobazzi@live.it;
   sgarraluca@gmail.com; monica.montagnani@uniba.it
RI Montagnani, Monica/AAV-2057-2020; Sgarra, Luca/AAC-4773-2022
OI montagnani, monica/0000-0002-5697-8185; Sgarra,
   Luca/0000-0001-8475-8270; IACOBAZZI, DOMINGA/0000-0001-5977-0518
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NR 178
TC 24
Z9 25
U1 3
U2 23
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1420-3049
J9 MOLECULES
JI Molecules
PD JUL
PY 2020
VL 25
IS 13
AR 3061
DI 10.3390/molecules25133061
PG 20
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA MM6SM
UT WOS:000550284700001
PM 32635492
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Arinno, A
   Apaijai, N
   Chattipakorn, SC
   Chattipakorn, N
AF Arinno, Apiwan
   Apaijai, Nattayaporn
   Chattipakorn, Siriporn C.
   Chattipakorn, Nipon
TI The roles of resveratrol on cardiac mitochondrial function in cardiac
   diseases
SO EUROPEAN JOURNAL OF NUTRITION
LA English
DT Review
DE Resveratrol; Mitochondria; Cardiotoxicity; Cardiac ischemia-reperfusion
   injury; Chemotherapy
ID PERMEABILITY TRANSITION PORE; ACUTE MYOCARDIAL-INFARCTION; OXIDATIVE
   STRESS; INDUCED CARDIOTOXICITY; VENTRICULAR DYSFUNCTION; METABOLIC
   SYNDROME; ORAL RESVERATROL; IN-VITRO; SIRT1; APOPTOSIS
AB Left ventricular (LV) dysfunction is commonly associated with a variety of health conditions including acute myocardial infarction and obesity/diabetes. In addition, administration of several pharmacological agents such as anticancer, antiviral, and immunosuppressive drugs has been shown to be related with LV dysfunction. The molecular mechanism responsible for LV dysfunction has been extensively studied, and it has been proposed that the overproduction of reactive oxygen species (ROS) plays a crucial role in the regulation of this function. Mitochondria require the balance between ROS production and antioxidants to maintain their appropriate function and to prevent excessive ROS production. Thus, the excessive production of ROS and the reduced scavenging process under any pathological conditions could disrupt mitochondrial function, leading to energy depletion with subsequent cell death. Therefore, maintenance of the balance between oxidative stress and antioxidants is essential. Resveratrol, a stilbene, has been investigated extensively, and potentially used to treat or prevent various cardiovascular diseases. Resveratrol directly upregulates antioxidative capacity by increasing antioxidant genes such as heme oxygenase-1, superoxide dismutase, catalase, and glutathione. In this review, accumulated data from in vitro, ex vivo, and in vivo studies regarding the effects of resveratrol on cardiac mitochondrial function in cardiac pathologies are comprehensively summarized and discussed. Since there is no conclusive available clinical study regarding the effects of resveratrol on cardiac mitochondrial function, this review also aims to encourage more clinical investigations to confirm findings from basic research. This comprehensive review will provide insight regarding the potential mechanistic roles of resveratrol in preventing and/or treating patients with cardiovascular diseases to improve LV function and their health status.
C1 [Arinno, Apiwan; Apaijai, Nattayaporn; Chattipakorn, Siriporn C.; Chattipakorn, Nipon] Chiang Mai Univ, Cardiac Electrophysiol Res & Training Ctr, Fac Med, Chiang Mai 50200, Thailand.
   [Arinno, Apiwan; Apaijai, Nattayaporn; Chattipakorn, Siriporn C.; Chattipakorn, Nipon] Chiang Mai Univ, Ctr Excellence Cardiac Electrophysiol Res, Chiang Mai 50200, Thailand.
   [Arinno, Apiwan; Chattipakorn, Nipon] Chiang Mai Univ, Dept Physiol, Cardiac Electrophysiol Unit, Fac Med, Chiang Mai 50200, Thailand.
C3 Chiang Mai University; Chiang Mai University; Chiang Mai University
RP Chattipakorn, N (corresponding author), Chiang Mai Univ, Cardiac Electrophysiol Res & Training Ctr, Fac Med, Chiang Mai 50200, Thailand.; Chattipakorn, N (corresponding author), Chiang Mai Univ, Ctr Excellence Cardiac Electrophysiol Res, Chiang Mai 50200, Thailand.; Chattipakorn, N (corresponding author), Chiang Mai Univ, Dept Physiol, Cardiac Electrophysiol Unit, Fac Med, Chiang Mai 50200, Thailand.
EM nchattip@gmail.com
RI Chattipakorn, Nipon/AAJ-4049-2021
OI Chattipakorn, Siriporn/0000-0003-1677-7052; Chattipakorn,
   Nipon/0000-0003-3026-718X
FU Thailand Research Fund [RTA 6080003, TRG6280005]; NSTDA Research Chair
   grant from the National Science and Technology Development Agency
   Thailand; Chiang Mai University Center of Excellence Award
FX This work was supported by Thailand Research Fund grants: RTA 6080003
   (SCC), TRG6280005 (NA); the NSTDA Research Chair grant from the National
   Science and Technology Development Agency Thailand (NC), and the Chiang
   Mai University Center of Excellence Award (NC).
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NR 75
TC 18
Z9 20
U1 0
U2 21
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1436-6207
EI 1436-6215
J9 EUR J NUTR
JI Eur. J. Nutr.
PD FEB
PY 2021
VL 60
IS 1
BP 29
EP 44
DI 10.1007/s00394-020-02256-7
EA MAY 2020
PG 16
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA QD5RS
UT WOS:000530598900001
PM 32372266
DA 2025-06-11
ER

PT J
AU Mahli, A
   Thasler, WE
   Patsenker, E
   Müller, S
   Stickel, F
   Müller, M
   Seitz, HK
   Cederbaum, AI
   Hellerbrand, C
AF Mahli, Abdo
   Thasler, Wolfgang E.
   Patsenker, Eleonora
   Mueller, Sebastian
   Stickel, Felix
   Mueller, Martina
   Seitz, Helmut K.
   Cederbaum, Arthur I.
   Hellerbrand, Claus
TI Identification of cytochrome CYP2E1 as critical mediator of synergistic
   effects of alcohol and cellular lipid accumulation in hepatocytes in
   vitro
SO ONCOTARGET
LA English
DT Article
DE alcohol; steatosis; autophagy; CYP2E1; Pathology Section
ID NONALCOHOLIC FATTY LIVER; BODY-MASS INDEX; OXIDATIVE STRESS; INCREASED
   EXPRESSION; METABOLIC SYNDROME; UNITED-STATES; HEPG2 CELLS; NEW-MODEL;
   DISEASE; AUTOPHAGY
AB Clinical studies propose a causative link between the consumption of alcohol and the development and progression of liver disease in obese individuals. However, it is incompletely understood how alcohol and obesity interact and whether the combined effects are additive or synergistic. In this study, we developed an in vitro model to address this question. Lipid accumulation in primary human hepatocytes was induced by incubation with oleic acid. Subsequently, steatotic and control hepatocytes were incubated with up to 50 mM alcohol. This alcohol concentration on its own revealed only minimal effects but significantly enhanced oleate-induced lipogenesis and cellular triglyceride content compared to control cells. Similarly, lipid peroxidation, oxidative stress and pro-inflammatory gene expression as well as CYP2E1 levels and activity were synergistically induced by alcohol and steatosis. CYP2E1 inhibition blunted these synergistic pathological effects. Notably, alcohol and cellular steatosis also induced autophagy in a synergistic manner, and also this was mediated via CYP2E1. Further induction of autophagy ameliorated the joint effects of alcohol and oleic acid on hepatocellular lipid accumulation and inflammatory gene expression while inhibition of autophagy further enhanced the dual pathological effects. Further analyses revealed that the joint synergistic effect of alcohol and steatosis on autophagy was mediated via activation of the JNK-pathway. In summary, our data indicate that alcohol induces not only pathological but also protective mechanisms in steatotic hepatocytes via CYP2E1. These findings may have important implications on the prognosis and treatment of alcoholic liver disease particularly in obese individuals.
C1 [Mahli, Abdo; Mueller, Martina; Hellerbrand, Claus] Univ Hosp Regensburg, Dept Internal Med 1, Regensburg, Germany.
   [Thasler, Wolfgang E.] Univ Munich, Dept Surg, Grosshadern Tissue Bank, Munich, Germany.
   [Thasler, Wolfgang E.] Univ Munich, Dept Surg, Ctr Liver Cell Res, Munich, Germany.
   [Patsenker, Eleonora; Stickel, Felix] Univ Bern, Dept Clin Res, Bern, Switzerland.
   [Mueller, Sebastian; Seitz, Helmut K.] Heidelberg Univ, Alcohol Res Ctr, Heidelberg, Germany.
   [Mueller, Sebastian; Seitz, Helmut K.] Salem Med Ctr, Dept Med Gastroenter, Heidelberg, Germany.
   [Cederbaum, Arthur I.] Icahn Sch Med Mt Sinai, Dept Pharmacol & Syst Therapeut, New York, NY 10029 USA.
C3 University of Regensburg; University of Munich; University of Munich;
   University of Bern; Ruprecht Karls University Heidelberg; Icahn School
   of Medicine at Mount Sinai
RP Hellerbrand, C (corresponding author), Univ Hosp Regensburg, Dept Internal Med 1, Regensburg, Germany.
EM claus.hellerbrand@ukr.de
RI Mahli, Abdo/AAD-4744-2019; Martina, Mueller-Schilling/R-4162-2016
OI Mahli, Abdo/0000-0002-8333-7551; Muller-Schilling,
   Martina/0000-0002-8520-4568
FU German Research Foundation (DFG); European Research Area Board (ERAB)
FX This work was supported by the German Research Foundation (DFG) and the
   European Research Area Board (ERAB) to FS and CH.
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NR 56
TC 30
Z9 30
U1 0
U2 14
PU IMPACT JOURNALS LLC
PI ORCHARD PARK
PA 6666 E QUAKER ST, STE 1, ORCHARD PARK, NY 14127 USA
EI 1949-2553
J9 ONCOTARGET
JI Oncotarget
PD DEC 8
PY 2015
VL 6
IS 39
BP 41464
EP 41478
DI 10.18632/oncotarget.6203
PG 15
WC Oncology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Cell Biology
GA CY0TR
UT WOS:000366119600007
PM 26497211
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Nistala, R
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   Lastra, G
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   Aroor, AR
   Hayden, MR
   Garro, M
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   Whaley-Connell, A
   Sowers, JR
AF Nistala, Ravi
   Habibi, Javad
   Lastra, Guido
   Manrique, Camila
   Aroor, Annayya R.
   Hayden, Melvin R.
   Garro, Mona
   Meuth, Alex
   Johnson, Megan
   Whaley-Connell, Adam
   Sowers, James R.
TI Prevention of Obesity-Induced Renal Injury in Male Mice by DPP4
   Inhibition
SO ENDOCRINOLOGY
LA English
DT Article
ID DIPEPTIDYL-PEPTIDASE-IV; CHRONIC KIDNEY-DISEASE; HIGH-FAT DIET;
   METABOLIC SYNDROME; URIC-ACID; INSULIN-RESISTANCE; OXIDATIVE STRESS;
   BLOOD-PRESSURE; POTENTIAL ROLE; INFLAMMATION
AB Therapies to prevent renal injury in obese hypertensive individuals are being actively sought due to the obesity epidemic arising from the Western diet (WD), which is high in fructose and fat. Recently, activation of the immune system and hyperuricemia, observed with high fructose intake, have been linked to the pathophysiology of hypertension and renal injury. Because dipeptidyl peptidase 4 (DPP4) is a driver of maladaptive T-cell/macrophage responses, renal-protective benefits of DPP4 inhibition in the WD-fed mice were examined. Mice fed a WD for 16 weeks were given the DPP4 inhibitor MK0626 in their diet beginning at 4 weeks of age. WD-fed mice were obese, hypertensive, and insulin-resistant and manifested proteinuria and increased plasma DPP4 activity and uric acid levels. WD-fed mice also had elevated kidney DPP4 activity and monocyte chemoattractant protein-1 and IL-12 levels and suppressed IL-10 levels in the kidney, suggesting macrophage- driven inflammation, glomerular and tubulointerstitial injury. WD-induced increases in DPP4 activation in the plasma and kidney and proteinuria in WD mice were abrogated by MK0626, although blood pressure and systemic insulin sensitivity were not improved. Contemporaneously, MK0626 reduced serum uric acid levels, renal oxidative stress, and IL-12 levels and increased IL-10 levels, suggesting that suppression of DPP4 activity leads to suppression of renal immune/inflammatory injury responses to a WD. Taken together, these results demonstrate that DPP4 inhibition prevents high-fructose/high-fat diet-induced glomerular and tubular injury independent of blood pressure/insulin sensitivity and offers a potentially novel therapy for diabetic and obesity-related kidney disease.
C1 [Nistala, Ravi; Meuth, Alex; Whaley-Connell, Adam] Univ Missouri, Sch Med, Div Nephrol & Hypertens, Columbia, MO 65212 USA.
   [Habibi, Javad; Lastra, Guido; Manrique, Camila; Aroor, Annayya R.; Hayden, Melvin R.; Garro, Mona; Whaley-Connell, Adam; Sowers, James R.] Univ Missouri, Sch Med, Div Endocrinol & Metab, Columbia, MO 65212 USA.
   [Nistala, Ravi; Habibi, Javad; Lastra, Guido; Manrique, Camila; Aroor, Annayya R.; Hayden, Melvin R.; Garro, Mona; Meuth, Alex; Whaley-Connell, Adam; Sowers, James R.] Univ Missouri, Sch Med, Dept Internal Med, Columbia, MO 65212 USA.
   [Sowers, James R.] Univ Missouri, Sch Med, Dept Med Pharmacol & Physiol, Columbia, MO 65212 USA.
   [Nistala, Ravi; Habibi, Javad; Lastra, Guido; Manrique, Camila; Aroor, Annayya R.; Hayden, Melvin R.; Garro, Mona; Meuth, Alex; Johnson, Megan; Whaley-Connell, Adam; Sowers, James R.] Univ Missouri, Sch Med, Diabet & Cardiovasc Ctr, Columbia, MO 65212 USA.
   [Whaley-Connell, Adam; Sowers, James R.] Harry S Truman Mem Vet Hosp, Columbia, MO 65201 USA.
C3 University of Missouri System; University of Missouri Columbia;
   University of Missouri System; University of Missouri Columbia;
   University of Missouri System; University of Missouri Columbia;
   University of Missouri System; University of Missouri Columbia;
   University of Missouri System; University of Missouri Columbia; US
   Department of Veterans Affairs; Veterans Health Administration (VHA);
   Harry S. Truman Memorial Veterans' Hospital
RP Nistala, R (corresponding author), Univ Missouri, Sch Med, Dept Internal Med, Div Nephrol, CE320,One Hosp Dr, Columbia, MO 65212 USA.
EM nistalar@health.missouri.edu
OI Whaley-Connell, Adam/0000-0001-8955-5560
FU Merck Pharmaceutical grant; National Institutes of Health [NIH HL-73101,
   NIH HL-107910, NIH AG040638]; U.S. Department of Veterans Affairs VA
   Merit Award; American Society of Nephrology-Association of Specialty
   Professors (ASN-ASP) Junior Development Grant in Geriatric Nephrology -
   T. Franklin Williams Scholarship Award; Atlantic Philanthropies, Inc;
   John A. Hartford Foundation; Association of Specialty Professors;
   Dialysis Clinics Inc
FX This work was supported by a Merck Pharmaceutical grant (to R.N. and
   J.H.); Dialysis Clinics Inc research support (to R.N.); National
   Institutes of Health Grants NIH HL-73101, NIH HL-107910 (to J.R.S.), and
   NIH AG040638 (to A.W.C.); a U.S. Department of Veterans Affairs VA Merit
   Award (to J.R.S.) and CDA2 BB-47 (to A.W.C.); and the American Society
   of Nephrology-Association of Specialty Professors (ASN-ASP) Junior
   Development Grant in Geriatric Nephrology (A.W.C.) supported by a T.
   Franklin Williams Scholarship Award. Funding was provided by Atlantic
   Philanthropies, Inc; the John A. Hartford Foundation; and the
   Association of Specialty Professors.
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NR 62
TC 46
Z9 51
U1 0
U2 10
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0013-7227
EI 1945-7170
J9 ENDOCRINOLOGY
JI Endocrinology
PD JUN
PY 2014
VL 155
IS 6
BP 2266
EP 2276
DI 10.1210/en.2013-1920
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA AP8QE
UT WOS:000342342900021
PM 24712875
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Park, K
   Steffes, M
   Lee, DH
   Himes, JH
   Jacobs, DR
AF Park, K.
   Steffes, M.
   Lee, D-H.
   Himes, J. H.
   Jacobs, D. R., Jr.
TI Association of inflammation with worsening HOMA-insulin resistance
SO DIABETOLOGIA
LA English
DT Article
DE Inflammation; Insulin resistance; Obesity
ID C-REACTIVE PROTEIN; TUMOR-NECROSIS-FACTOR; ADIPOSE-TISSUE; METABOLIC
   SYNDROME; FACTOR-ALPHA; OBESITY; EXPRESSION; LIPOPROTEIN; GLUCOSE;
   DENSITY
AB Aims/hypothesis We examined the cross-sectional and longitudinal relationships between C-reactive protein (CRP), a marker of low-grade inflammation, and insulin resistance and whether the association was independent of obesity and oxidative stress.
   Methods CRP and insulin resistance (homeostasis model assessment of insulin resistance [HOMA-IR]) data were obtained in a population-based, prospective observational study, Coronary Artery Risk Development in Young Adults (CARDIA), during 1992-2006.
   Results CRP showed a significant positive association with insulin resistance, both cross-sectionally and longitudinally (5 year follow-up). The estimated increment in HOMA-IR was 0.34 log(e)(pmol/l x [mmol/l]/156.25) (p value for trend <0.0001) in the highest vs lowest CRP quartiles in cross-sectional analysis, whereas the corresponding estimate was 0.12 (p trend <0.0001) in the highest vs lowest CRP quartiles longitudinally over 5 years. The gradient of HOMA-IR across CRP was attenuated but remained statistically significant after controlling for body fat measurements (0.06 in the highest vs lowest CRP in both cross-sectional [p value for trend=0.001] and longitudinal analyses [p value for trend=0.01]), and was little changed by further adjustment for oxidative stress markers (F-2-isoprostanes and oxidised LDL). There were consistent increments in the levels of HOMA-IR with increasing concentrations of CRP over time. In contrast, higher HOMA-IR did not predict future increases in CRP. Findings were similar using fibrinogen as the predictor variable.
   Conclusions/interpretation Although a substantial portion of this association was explained by obesity, CRP was independently related to concurrent and future insulin resistance.
C1 [Park, K.; Himes, J. H.; Jacobs, D. R., Jr.] Univ Minnesota, Div Epidemiol & Community Hlth, Sch Publ Hlth, Minneapolis, MN 55454 USA.
   [Steffes, M.] Univ Minnesota, Dept Lab Med & Pathol, Minneapolis, MN 55454 USA.
   [Lee, D-H.] Kyungpook Natl Univ, Dept Prevent Med, Sch Med, Coll Med, Taegu, South Korea.
   [Jacobs, D. R., Jr.] Univ Oslo, Dept Nutr, Oslo, Norway.
C3 University of Minnesota System; University of Minnesota Twin Cities;
   University of Minnesota System; University of Minnesota Twin Cities;
   Kyungpook National University (KNU); University of Oslo
RP Jacobs, DR (corresponding author), Univ Minnesota, Div Epidemiol & Community Hlth, Sch Publ Hlth, 1300 S 2nd St,Suite 300, Minneapolis, MN 55454 USA.
EM jacobs@epi.umn.edu
RI Park, Kyong/AFJ-9812-2022; Jacobs, David/G-5405-2011
OI Park, Kyong/0000-0002-4681-1584; Jacobs, David/0000-0002-7232-0543
FU National Heart, Lung, and Blood Institute [N01-HC-95095, N01-HC-48047,
   N01-HC-48048, N01-HC-48049, R01-HL-53560]; National Institutes of
   Health; Coronary Artery Risk De velopment in Young Adults (CARDIA study)
FX Source of funding: this research was supported by contracts
   N01-HC-95095, N01-HC-48047, N01-HC-48048, and N01-HC-48049 and a grant
   R01-HL-53560, all from the National Heart, Lung, and Blood Institute,
   National Institutes of Health, Coronary Artery Risk De velopment in
   Young Adults (CARDIA study).
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NR 16
TC 52
Z9 55
U1 0
U2 8
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0012-186X
EI 1432-0428
J9 DIABETOLOGIA
JI Diabetologia
PD NOV
PY 2009
VL 52
IS 11
BP 2337
EP 2344
DI 10.1007/s00125-009-1486-5
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 504XE
UT WOS:000270650600012
PM 19680627
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Malheiro, LFL
   Fernandes, MM
   Oliveira, CA
   Barcelos, ID
   Fernandes, AJV
   Silva, BS
   Avila, JS
   Soares, TD
   Amaral, LSD
AF Malheiro, Lara Fabiana Luz
   Fernandes, Mariana Masimessi
   Oliveira, Caroline Assuncao
   Barcelos, Isadora de Souza
   Fernandes, Ana Jullie Veiga
   Silva, Bruna Santos
   Avila, Julia Spinola
   Soares, Telma de Jesus
   Amaral, Liliany Souza de Brito
TI Renoprotective mechanisms of exercise training against acute and chronic
   renal diseases - A perspective based on experimental studies
SO LIFE SCIENCES
LA English
DT Review
DE Acute kidney injury; Chronic kidney disease; Exercise training;
   Renoprotection
ID ACUTE KIDNEY INJURY; NITRIC-OXIDE; OXIDATIVE STRESS; PHYSICAL-EXERCISE;
   CARDIOVASCULAR BURDEN; INTERSTITIAL FIBROSIS; DIABETIC-NEPHROPATHY;
   METABOLIC SYNDROME; AEROBIC EXERCISE; GROWTH-FACTOR
AB Regular exercise training can lead to several health benefits, reduce mortality risk, and increase life expectancy. On the other hand, a sedentary lifestyle is a known risk factor for chronic diseases and increased mortality. Acute kidney injury (AKI) and chronic kidney disease (CKD) represent a significant global health problem, affecting millions of people worldwide. The progression from AKI to CKD is well-recognized in the literature, and exercise training has emerged as a potential renoprotective strategy. Thus, this article aims to review the main molecular mechanisms underlying the renoprotective actions of exercise training in the context of AKI and CKD, focusing on its antioxidative, anti-inflammatory, anti-apoptotic, anti-fibrotic, and autophagy regulatory effects. For that, bibliographical research was carried out in Medline/PubMed and Scielo databases. Although the pathophysiological mechanisms involved in renal diseases are not fully understood, experimental studies demonstrate that oxidative stress, inflammation, apoptosis, and dysregulation of fibrotic and autophagic processes play central roles in the development of tissue damage. Increasing evidence has suggested that exercise can beneficially modulate these mechanisms, potentially becoming a safe and effective non-pharmacological strategy for kidney health protection and promotion. Thus, the evidence base discussed in this review suggests that an adequate training program emerges as a valuable tool for preserving renal function in experimental animals, mainly through the production of antioxidant enzymes, nitric oxide (NO), irisin, IL-10, and IL-11. Future research can continue to explore these mechanisms to develop specific guidelines for the prescription of exercise training in different populations of patients with kidney diseases.
C1 [Malheiro, Lara Fabiana Luz; Fernandes, Mariana Masimessi; Oliveira, Caroline Assuncao; Barcelos, Isadora de Souza; Fernandes, Ana Jullie Veiga; Silva, Bruna Santos; Avila, Julia Spinola; Soares, Telma de Jesus; Amaral, Liliany Souza de Brito] Univ Fed Bahia, Inst Multidisciplinar Saude, Rua Rio Contas 58, BR-45029094 Vitoria Da Conquista, BA, Brazil.
   [Malheiro, Lara Fabiana Luz; Oliveira, Caroline Assuncao; Soares, Telma de Jesus; Amaral, Liliany Souza de Brito] Programa Posgrad Multictr Ciencias Fisiol, Vitoria Da Conquista, Brazil.
   [Soares, Telma de Jesus; Amaral, Liliany Souza de Brito] Programa Posgrad Biociencias, Vitoria Da Conquista, Brazil.
C3 Universidade Federal da Bahia
RP Amaral, LSD (corresponding author), Univ Fed Bahia, Inst Multidisciplinar Saude, Rua Rio Contas 58, BR-45029094 Vitoria Da Conquista, BA, Brazil.
EM liliany.amaral@ufba.br
OI Amaral, Liliany/0000-0002-8434-0146
FU Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
   [433542/2018-7, 404752/2023-3]; Fundacao de Amparo a Pesquisa do Estado
   da Bahia (FAPESB) [BOL0596/2022, BOL0766/2023]; Programa Institucional
   de Bolsa de Iniciacao Cientifica (PIBIC) from Conselho Nacional de
   Desenvolvimento Cientifico e Tecnologico (CNPq) [01/2023]; Universidade
   Federal da Bahia (UFBA) [01/2022]
FX This work was supported by Conselho Nacional de Desenvolvimento
   Cientifico e Tecnologico (CNPq), grant numbers: 433542/2018-7 and
   404752/2023-3; the Fundacao de Amparo a Pesquisa do Estado da Bahia
   (FAPESB), grant numbers: BOL0596/2022 and BOL0766/2023; Programa
   Institucional de Bolsa de Iniciacao Cientifica (PIBIC) from Conselho
   Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq), grant
   number: 01/2023, and Universidade Federal da Bahia (UFBA), grant number:
   01/2022.
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NR 154
TC 3
Z9 3
U1 1
U2 7
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0024-3205
EI 1879-0631
J9 LIFE SCI
JI Life Sci.
PD JUN 1
PY 2024
VL 346
AR 122628
DI 10.1016/j.lfs.2024.122628
EA APR 2024
PG 13
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA D8G7T
UT WOS:001298518400001
PM 38614303
DA 2025-06-11
ER

PT J
AU de Novaes, JF
   Filgueiras, MD
   Suhett, LG
   Silva, MA
   de Albuquerque, FM
   Fonseca, RMS
   Peluzio, MDG
AF de Novaes, Juliana Farias
   Filgueiras, Mariana De Santis
   Suhett, Lara Gomes
   Silva, Mariane Alves
   de Albuquerque, Fernanda Martins
   Fonseca, Rafaela Mara Silva
   Peluzio, Maria do Carmo Gouveia
TI Higher serum uric acid is associated with body fat, retinol-binding
   protein 4, and antioxidative status in Brazilian children
SO NUTRITION
LA English
DT Article
DE Children; Uric acid; Adiposity; Adipokines; Oxidative stress
ID INSULIN-RESISTANCE; METABOLIC SYNDROME; OXIDATIVE STRESS;
   ADIPOSE-TISSUE; VISCERAL FAT; OBESITY; INFLAMMATION; ADIPOKINES;
   MARKERS; INCREASE
AB Objective: The aim of this study was to evaluate the association of serum uric acid (SUA) with adiposity, adi-pokines, and anti-and oxidative markers in Brazilian children.Methods: This was a cross-sectional investigation with 378 children ages 8 to 9 yin Vi,cosa, Minas Gerais, Bra-zil. Information on sociodemographic and lifestyle characteristics was obtained via questionnaires, and body fat was determined by dual energy x-ray absorptiometry. We compared the distributions of adiposity (total and central), adipokines (adiponectin, chemerin, leptin, and retinol-binding protein 4 [RBP4]), anti-and oxi-dative markers (plasma ferric reducing antioxidant power [FRAP], superoxide dismutase [SOD], and malon-dialdehyde [MDA]) by SUA categories using linear regression.Results: SUA was positively associated with total and central fat. Every standard deviation (SD) of SUA was related, respectively, to a 3.4 (95% confidence interval [CI], 2.4-4.4), 4 (95% CI, 2.8-5.1), 4.2 (95% CI, 2.9-5.5), and 3.5 (95% CI, 2.4-4.6) units higher of total, truncal, android, and gynoid fat. We found a positive associa-tion of SUA with RBP4 and FRAP, and a negative association with MDA. Every SD of SUA was related, respec-tively, to 0.1 (95% CI, 0.01-0.1) and 7.8 (95% CI, 5.5-10.1) units higher of RBP4 and FRAP; and to-0.3 (95% CI,-0.5 to-0.1) units lower of MDA.Conclusions: SUA was positively associated with adiposity, RBP4, and antioxidative status in Brazilian chil-dren.& COPY; 2023 Elsevier Inc. All rights reserved.
C1 [de Novaes, Juliana Farias; Filgueiras, Mariana De Santis; Fonseca, Rafaela Mara Silva; Peluzio, Maria do Carmo Gouveia] Univ Fed Vicosa, Dept Nutr & Hlth, Vicosa, Brazil.
   [Suhett, Lara Gomes] Drexel Univ, Coll Nursing & Hlth Profess, Dept Nutr Sci, Philadelphia, PA 19102 USA.
   [Silva, Mariane Alves] Univ Fed Mato Grosso, Nutr Fac, Cuiaba, Brazil.
   [de Albuquerque, Fernanda Martins] Ctr Univ UniAcad, Nutr Fac, Juiz De Fora, Brazil.
C3 Universidade Federal de Vicosa; Drexel University; Universidade Federal
   de Mato Grosso
RP de Novaes, JF (corresponding author), Univ Fed Vicosa, Dept Nutr & Hlth, Vicosa, Brazil.
EM jnovaes@ufv.br
RI Suhett, Lara/AHC-0204-2022; Fonseca, Rafaela/JVN-1053-2024; Filgueiras,
   Mariana/Q-6096-2018
OI PELUZIO, MARIA DO CARMO GOUVEIA/0000-0003-4665-7043
FU Fundacao de Amparo a~Pesquisa do Estado de Minas Gerais (FAPEMIG)
   [CDS-APQ-02979-16]; Conselho Nacional de Desenvolvimento Cientifico e
   Tecnologico (CNPq) [407547/2012-6, 478910/2013-4]; Coordenacao de
   Aperfeicoamento de Nivel Superior - Brasil (CAPES) [001]
FX Financial support for this study was received from the Fundacao de
   Amparo a & nbsp;Pesquisa do Estado de Minas Gerais (FAPEMIG; grant
   number CDS-APQ-02979-16), the Conselho Nacional de Desenvolvimento
   Cientifico e Tecnologico (CNPq; grant numbers 407547/2012-6 and
   478910/2013-4), and the Coordenacao de Aperfeicoamento de Nivel Superior
   - Brasil (CAPES; code 001).
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NR 51
TC 0
Z9 0
U1 0
U2 2
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0899-9007
EI 1873-1244
J9 NUTRITION
JI Nutrition
PD SEP
PY 2023
VL 113
AR 112079
DI 10.1016/j.nut.2023.112079
EA JUN 2023
PG 6
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA Q1FC9
UT WOS:001055034300001
PM 37354651
DA 2025-06-11
ER

PT J
AU Faught, E
   Vijayan, MM
AF Faught, Erin
   Vijayan, Mathilakath M.
TI The Mineralocorticoid Receptor Functions as a Key Glucose Regulator in
   the Skeletal Muscle of Zebrafish
SO ENDOCRINOLOGY
LA English
DT Article
DE glucocorticoid receptor; mineralocorticoid receptor; metabolism;
   glucose; triglycerides; metabolic flexibility
ID GLUCOCORTICOID-RECEPTOR; INSULIN-RESISTANCE; METABOLIC SYNDROME; FISH;
   MICE; MECHANISMS; CORTISOL; KINETICS; GENES; TIME
AB Glucocorticoids (GCs) are essential for maintaining energy homeostasis as part of the adaptive stress response. Most work to date has characterized the metabolic role of GCs via the activation of the glucocorticoid receptor (nr3c1; GR), which is activated under high GC conditions. However, GCs also bind to the mineralocorticoid receptor (nr3c2; MR), a high-affinity corticosteroid receptor active under basal GC conditions. Despite the expression of MR in skeletal muscles, almost nothing is known about its physiological role. Here we tested the hypothesis that the MR promotes anabolic processes during resting cortisol levels and curtails the catabolic actions of the GR during high (stressed) levels of cortisol. To determine the effect of MR, a zebrafish line with a ubiquitous MR knockout (MRca402/ca402) was utilized. The GR was activated in the same group by chronically treating fish with exogenous cortisol. In the muscle, MR primarily promoted nutrient storage, and restricted energy substrate mobilization under resting conditions, whereas GR activation resulted in increased nutrient utilization. Interestingly, MR loss improved GR-driven metabolic flexibility, suggesting that the activation state of these receptors is a key determinant of skeletal muscle ability to switch fuel sources. To determine if the anabolism-promoting nature of MR was due to an interaction with insulin, fish were co-injected with insulin and the fluorescent glucose analogue 2-NBDG. A loss of MR abolished insulin-stimulated glucose uptake in the skeletal muscle. Taken together, we postulate that MR acts as a key modulator of glucose metabolism in the musculature during basal and stress conditions.
C1 [Faught, Erin; Vijayan, Mathilakath M.] Univ Calgary, Dept Biol Sci, 2500 Univ Dr NW, Calgary, AB T2N 1N4, Canada.
C3 University of Calgary
RP Vijayan, MM (corresponding author), Univ Calgary, Dept Biol Sci, 2500 Univ Dr NW, Calgary, AB T2N 1N4, Canada.
EM matt.vijayan@ucalgary.ca
RI Vijayan, Mathilakath/AAC-2190-2020
FU Natural Sciences and Engineering Research Council (NSERC) of Canada
FX Natural Sciences and Engineering Research Council (NSERC) of Canada
   Discovery Grant to M.M.V.
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NR 69
TC 10
Z9 11
U1 2
U2 19
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0013-7227
EI 1945-7170
J9 ENDOCRINOLOGY
JI Endocrinology
PD OCT 11
PY 2022
VL 163
IS 11
AR bqac149
DI 10.1210/endocr/bqac149
PG 14
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 5K0CM
UT WOS:000869402700004
PM 36041019
OA Bronze
DA 2025-06-11
ER

PT J
AU Erbetta, K
   Almeida, J
   Waldman, MR
AF Erbetta, Kristin
   Almeida, Joanna
   Waldman, Marcus R.
TI Racial, ethnic and nativity inequalities in gestational diabetes
   mellitus: The role of racial discrimination
SO SSM-POPULATION HEALTH
LA English
DT Article
DE Racial/ethnic/nativity inequities; Gestational diabetes; Racial
   discrimination
ID ADVERSE BIRTH OUTCOMES; BODY-FAT DISTRIBUTION; SELF-RATED HEALTH;
   INTERNALIZED RACISM; PSYCHOSOCIAL STRESS; INSULIN-RESISTANCE;
   GLUCOSE-INTOLERANCE; METABOLIC SYNDROME; PERCEIVED STRESS; FASTING
   GLUCOSE
AB Introduction: Racial/ethnic minority and foreign-born women in the United States are at high risk of experiencing racial discrimination, which is associated with adverse health outcomes. Although racial discrimination is associated with metabolic disturbances such as insulin resistance and type 2 diabetes, more studies should examine its effect on gestational diabetes mellitus (GDM), which is highest among racial/ethnic minority and foreign-born women.
   Methods: We used New York City Pregnancy Risk and Assessment Monitoring System survey data (2012-2014) linked with birth certificate items (N = 4084) in bivariate and multivariate analyses to examine racial/ethnic/nativity differences in racial discrimination, and to test if racial discrimination explains racial/ethnic/nativity inequalities in GDM.
   Results: The 12-month prevalence of racial discrimination (9.5%) varied across race/ethnicity and nativity status, with Black, Hispanic and foreign-born women having the highest prevalence. Interaction effects indicate that US-born Black and Hispanic women are at increased risk of racial discrimination compared to their foreign-born counterparts. Women with GDM had statistically higher prevalence of racial discrimination (14%) compared with women without GDM (9%). Racial discrimination was associated with a 57% increased unadjusted risk of GDM (RR = 1.57, 95% CI [1.19, 2.06]) that decreased to 24% after adjusting for all covariates (RR = 1.24, 95% CI [0.87, 1.78]).
   Discussion: The high proportion of racial/ethnic minority and foreign-born women experiencing racial discrimination, and its potential impact on GDM, underscores the importance of culturally informed screening and intervention approaches by trained professionals.
C1 [Erbetta, Kristin; Almeida, Joanna] Simmons Univ, 300 Fenway, Boston, MA 02115 USA.
   [Waldman, Marcus R.] Univ Nebraska, Med Ctr, 42nd & Emile, Omaha, NE 68198 USA.
C3 Simmons University; University of Nebraska System; University of
   Nebraska Medical Center
RP Erbetta, K (corresponding author), Simmons Univ, 300 Fenway, Boston, MA 02115 USA.
EM kristin.erbetta@simmons.edu; joanna.almeida@simmons.edu;
   marcus.waldman@unmc.edu
OI Erbetta, Kristin/0000-0003-4013-7602; Waldman,
   Marcus/0000-0002-3288-4803
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NR 54
TC 10
Z9 10
U1 0
U2 6
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 2352-8273
J9 SSM-POPUL HLTH
JI SSM-Popul. Health
PD SEP
PY 2022
VL 19
AR 101176
DI 10.1016/j.ssmph.2022.101176
EA JUL 2022
PG 10
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA 3Q3RE
UT WOS:000838151100001
PM 35928172
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Castellano, JM
   Espinosa, JM
   Perona, JS
AF Castellano, Jose M.
   Espinosa, Juan M.
   Perona, Javier S.
TI Modulation of Lipid Transport and Adipose Tissue Deposition by Small
   Lipophilic Compounds
SO FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
LA English
DT Review
DE tocopherol; carotenoid; sterol; triterpene; metabolism; metabolic
   disease
ID RICE BRAN OIL; SCAVENGER RECEPTOR EXPRESSION; ENDOPLASMIC-RETICULUM
   STRESS; TOMATO JUICE SUPPLEMENTATION; OLEANOLIC ACID PROTECTS;
   LOW-DENSITY-LIPOPROTEIN; FAT-SOLUBLE VITAMINS; ALPHA-TOCOPHEROL; PLANT
   STEROLS; INSULIN-RESISTANCE
AB Small lipophilic molecules present in foods of plant origin have relevant biological activities at rather low concentrations. Evidence suggests that phytosterols, carotenoids, terpenoids, and tocopherols can interact with different metabolic pathways, exerting beneficial effects against a number of metabolic diseases. These small molecules can modulate triacylglycerol absorption in the intestine and the biosynthesis of chylomicrons, the lipid carriers in the blood. Once in the bloodstream, they can impact lipoprotein clearance from blood, thereby affecting fatty acid release, incorporation into adipocytes and triglyceride reassembling and deposit. Consequently, some of these molecules can regulate pathophysiological processes associated to obesity and its related conditions, such as insulin resistance, metabolic syndrome and type-2 diabetes. The protective capacity of some lipophilic small molecules on oxidative and chemotoxic stress, can modify the expression of key genes in the adaptive cellular response, such as transcription factors, contributing to prevent the inflammatory status of adipose tissue. These small lipophilic compounds can be incorporated into diet as natural parts of food but they can also be employed to supplement other dietary and pharmacologic products as nutraceuticals, exerting protective effects against the development of metabolic diseases in which inflammation is involved. The aim of this review is to summarize the current knowledge of the influence of dietary lipophilic small biomolecules (phytosterols, carotenoids, tocopherols, and triterpenes) on lipid transport, as well as on the effects they may have on pathophysiological metabolic states, related to obesity, insulin resistance and inflammation, providing an evidence-based summary of their main beneficial effects on human health.
C1 [Castellano, Jose M.; Espinosa, Juan M.; Perona, Javier S.] CSIC, Inst Grasa, Dept Food & Hlth, Grp Bioact Cpds Nutr & Hlth, Seville, Spain.
C3 Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Instituto
   de la Grasa (IG)
RP Perona, JS (corresponding author), CSIC, Inst Grasa, Dept Food & Hlth, Grp Bioact Cpds Nutr & Hlth, Seville, Spain.
EM perona@ig.csic.es
RI Perona, J/B-9721-2014; Espinosa, JM/LHA-6797-2024; Castellano Orozco,
   Jose Maria/L-6220-2014
OI Castellano Orozco, Jose Maria/0000-0003-3051-3264
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   2010, FED REG, V75, P76526
NR 192
TC 14
Z9 14
U1 0
U2 24
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-634X
J9 FRONT CELL DEV BIOL
JI Front. Cell. Dev. Biol.
PD OCT 14
PY 2020
VL 8
AR 555359
DI 10.3389/fcell.2020.555359
PG 15
WC Cell Biology; Developmental Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Developmental Biology
GA OK1FX
UT WOS:000584398300001
PM 33163484
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Mitchell, UA
   Dellor, ED
   Sharif, MZ
   Brown, LL
   Torres, JM
   Nguyen, AW
AF Mitchell, Uchechi A.
   Dellor, Elinam D.
   Sharif, Mienah Z.
   Brown, Lauren L.
   Torres, Jacqueline M.
   Nguyen, Ann W.
TI When Is Hope Enough? Hopefulness, Discrimination and Racial/Ethnic
   Disparities in Allostatic Load
SO BEHAVIORAL MEDICINE
LA English
DT Article
DE aging; physiological dysregulation; psychosocial resources; resilience;
   stress and coping
ID SELF-REPORTED EXPERIENCES; ISCHEMIC-HEART-DISEASE; AFRICAN-AMERICAN MEN;
   ALL-CAUSE MORTALITY; SOCIOECONOMIC-STATUS; RACIAL-DISCRIMINATION;
   JOHN-HENRYISM; PSYCHOSOCIAL RESOURCES; METABOLIC SYNDROME; PULSE
   PRESSURE
AB Hopefulness is associated with better health and may be integral for stress adaptation and resilience. Limited research has prospectively examined whether hopefulness protects against physiological dysregulation or does so similarly for U.S. whites, blacks and Hispanics. We examined the association between baseline hopefulness and future allostatic load using data from the Health and Retirement Study (n = 8,486) and assessed differences in this association by race/ethnicity and experiences of discrimination. Four items measured hopefulness and allostatic load was a count of seven biomarkers for which a respondent's measured value was considered high-risk for disease. A dichotomous variable assessed whether respondents experienced at least one major act of discrimination in their lifetime. We used Poisson regression to examine the association between hopefulness and allostatic load and included a multiplicative interaction term to test racial/ethnic differences in this association. Subsequent analyses were stratified by race/ethnicity and tested the interaction between hopefulness and discrimination within each racial/ethnic group. Hopefulness was associated with lower allostatic load scores, but its effects varied significantly by race/ethnicity. Race-stratified analyses suggested that hopefulness was protective among whites and not associated with allostatic load among Hispanics irrespective of experiencing discrimination. Hopefulness was associated with lower allostatic load among blacks reporting discrimination but associated with higher allostatic load among those who did not. Findings suggest that hopefulness plays differing roles for older whites, blacks and Hispanics and, for blacks, its protective effects on physiological dysregulation are intricately tied to their experiences of discrimination.
C1 [Mitchell, Uchechi A.] Univ Illinois, Sch Publ Hlth, Div Community Hlth Sci, 1603 W Taylor St, Chicago, IL 60612 USA.
   [Dellor, Elinam D.] Ohio State Univ, Coll Social Work, Columbus, OH 43210 USA.
   [Sharif, Mienah Z.] Univ Calif Los Angeles, Ctr Racism Social Justice & Hlth, Los Angeles, CA 90024 USA.
   [Brown, Lauren L.] Univ Michigan, Populat Studies Ctr, Inst Social Res, Ann Arbor, MI 48109 USA.
   [Torres, Jacqueline M.] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA.
   [Nguyen, Ann W.] Case Western Reserve Univ, Jack Joseph & Morton Mandel Sch Appl Social Sci, Cleveland, OH 44106 USA.
C3 University of Illinois System; University of Illinois Chicago;
   University of Illinois Chicago Hospital; University System of Ohio; Ohio
   State University; University of California System; University of
   California Los Angeles; University of Michigan System; University of
   Michigan; University of California System; University of California San
   Francisco; University System of Ohio; Case Western Reserve University
RP Mitchell, UA (corresponding author), Univ Illinois, Sch Publ Hlth, Div Community Hlth Sci, 1603 W Taylor St, Chicago, IL 60612 USA.
EM umitch@uic.edu
RI Nguyen, Ann/AAD-7793-2022
OI Dellor, Elinam D./0000-0002-7608-6029; Mitchell,
   Uchechi/0000-0003-1675-1119; Brown, Lauren/0000-0002-1681-8267
FU National Institute on Aging [T32AG000221, U01AG009740, K01AG056602]
   Funding Source: NIH RePORTER
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NR 115
TC 22
Z9 26
U1 0
U2 17
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 0896-4289
EI 1940-4026
J9 BEHAV MED
JI Behav. Med.
PD OCT 1
PY 2020
VL 46
IS 3-4
BP 189
EP 201
DI 10.1080/08964289.2020.1729086
PG 13
WC Behavioral Sciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Behavioral Sciences; Psychiatry
GA NA8FJ
UT WOS:000560052900002
PM 32787721
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Pomian, A
   Lisik, W
   Kosieradzki, M
   Barcz, E
AF Pomian, Andrzej
   Lisik, Wojciech
   Kosieradzki, Maciej
   Barcz, Ewa
TI Obesity and Pelvic Floor Disorders: A Review of the Literature
SO MEDICAL SCIENCE MONITOR
LA English
DT Review
DE Obesity; Pelvic Organ Prolapse; Suburethral Slings; Urinary Incontinence
ID IMPROVING URINARY-INCONTINENCE; MID-URETHRAL SLINGS; VAGINAL TAPE TVT;
   BODY-MASS INDEX; RISK-FACTORS; STRESS-INCONTINENCE; WEIGHT-LOSS; FECAL
   INCONTINENCE; OVERACTIVE BLADDER; METABOLIC SYNDROME
AB Overweight and obesity are becoming a worldwide health problem associated with numerous co-morbidities. National costs of obesity and pelvic flor disorders have been rising since the 1950s across the world. Obesity is thought to have a very strong effect on pelvic floor disorders, and, considering the high prevalence of both problems worldwide, it is of utmost importance to evaluate the association between these pathologies as well as the impact of obesity on treatment efficacy. This review is based on a selection of reports in the literature (PubMed search), including guidelines and Cochrane reviews.
   Obesity seems to be a well-documented risk factor for lower urinary tract symptoms (LUTS) and is a predictor of exacerbation of stress urinary incontinence (SUI) and overactive bladder (OAB). Weight loss is also associated with improvement or resolution of SUI and OAB. In the case of pelvic organ prolapse (POP), weight loss is associated with improvement in quality of life. Although obesity is associated with POP in general, the exact role of obesity in symptomatic POP remains uncertain. While outcomes of anti-incontinence surgery among obese women are similar to those in non-obese women, postoperative urge incontinence is more likely to occur. It seems that obesity is not a risk factor for postoperative complications or short-term efficacy of POP surgical treatment. Long-term effects are still uncertain.
   Obesity is a strong risk factor for LUTS, but in most cases it does not affect efficacy of operative treatment. It may be associated with some post-operative complications. Weight loss in many cases allows avoiding surgical intervention.
C1 [Pomian, Andrzej; Barcz, Ewa] Med Univ Warsaw, Dept Obstet & Gynecol 1, Warsaw, Poland.
   [Lisik, Wojciech; Kosieradzki, Maciej] Med Univ Warsaw, Dept Gen Surg & Transplantol, Warsaw, Poland.
C3 Medical University of Warsaw; Medical University of Warsaw
RP Barcz, E (corresponding author), Med Univ Warsaw, Dept Obstet & Gynecol 1, Warsaw, Poland.
EM ewa.barcz@wum.edu.pl
RI Barcz, Ewa/AAS-7533-2020; Kosieradzki, Maciej/P-9470-2018; Barcz,
   Ewa/KLC-9324-2024; Lisik, Wojciech/Q-8972-2018
OI Barcz, Ewa/0000-0002-1289-9442; Kosieradzki, Maciej/0000-0003-2889-1311;
   Lisik, Wojciech/0000-0003-3020-3979
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NR 66
TC 60
Z9 67
U1 1
U2 12
PU INT SCIENTIFIC INFORMATION, INC
PI MELVILLE
PA 150 BROADHOLLOW RD, STE 114, MELVILLE, NY 11747 USA
EI 1643-3750
J9 MED SCI MONITOR
JI Med. Sci. Monitor
PD JUN 3
PY 2016
VL 22
BP 1880
EP 1886
DI 10.12659/MSM.896331
PG 7
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA DN4GU
UT WOS:000377022800001
PM 27255341
OA Green Published
DA 2025-06-11
ER

PT J
AU Battelli, MG
   Bolognesi, A
   Polito, L
AF Battelli, Maria Giulia
   Bolognesi, Andrea
   Polito, Letizia
TI Pathophysiology of circulating xanthine oxidoreductase: New emerging
   roles for a multi-tasking enzyme
SO BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
LA English
DT Review
DE Cardiovascular diseases; Endothelium functions; Metabolic syndrome;
   Oxidative stress; Uric acid; Xanthine oxidoreductase
ID ISCHEMIA-REPERFUSION INJURY; NITRIC-OXIDE SYNTHASE; CHRONIC
   HEART-FAILURE; SERUM URIC-ACID; PULMONARY ENDOTHELIAL-CELLS; HUMAN
   LIVER-TRANSPLANTATION; MAMMARY EPITHELIAL-CELLS; THORACIC AORTA
   OCCLUSION; OXYGEN-FREE-RADICALS; ACUTE LUNG INJURY
AB The enzyme xanthine oxidoreductase (XOR) catalyses the last step of purine degradation in the highest uricotelic primates as a rate-limiting enzyme in nucleic add catabolism. Although XOR has been studied for more than a century, this enzyme continues to arouse interest because its involvement in many pathological conditions is not completely known. XOR is highly evolutionarily conserved; moreover, its activity is very versatile and tuneable at multiple-levels and generates both oxidant and anti-oxidant products. This review covers the basic information on XOR biology that is essential to understand its enzymatic role in human pathophysiology and provides a comprehensive catalogue of the experimental and human pathologies associated with increased serum XOR levels. The production of radical species by XOR oxidase activity has been intensively studied and evaluated in recent decades in conjunction with the cytotoxic consequences and tissue injuries of various pathological conditions. More recently, a role has emerged for the activity of endothelium-bound enzymes in inducing the vascular response to oxidative stress, which includes the regulation of pro-inflammatory and pro-thrombotic activities of endothelial cells. The possible physiological functions of circulating XOR and the products of its enzyme activity are presented here together with their implications in cardiovascular and metabolic diseases. (C) 2014 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).
C1 [Battelli, Maria Giulia; Bolognesi, Andrea; Polito, Letizia] Univ Bologna, Alma Mater Studiorum, DIMES, Dept Expt Diagnost & Specialty Med, I-40126 Bologna, Italy.
C3 University of Bologna
RP Bolognesi, A (corresponding author), Univ Bologna, Alma Mater Studiorum, DIMES, Dept Expt Diagnost & Specialty Med, Via S Giacomo 14, I-40126 Bologna, Italy.
EM mariagiulia.battelli@unibo.it; andrea.bolognesi@unibo.it;
   letizia.polito@unibo.it
RI Bolognesi, Andrea/Q-6526-2017; Polito, Letizia/H-2877-2019; Battelli,
   Maria Giulia/G-2711-2015
OI Polito, Letizia/0000-0001-8051-4981; Battelli, Maria
   Giulia/0000-0001-6048-0454; Bolognesi, Andrea/0000-0001-7497-4586
FU Alma Mater Studiorum-University of Bologna; Pallotti Legacies for Cancer
   Research
FX This work was supported by funds for selected research topics from the
   Alma Mater Studiorum-University of Bologna and by the Pallotti Legacies
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NR 302
TC 207
Z9 219
U1 0
U2 41
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0925-4439
EI 0006-3002
J9 BBA-MOL BASIS DIS
JI Biochim. Biophys. Acta-Mol. Basis Dis.
PD SEP
PY 2014
VL 1842
IS 9
BP 1502
EP 1517
DI 10.1016/j.bbadis.2014.05.022
PG 16
WC Biochemistry & Molecular Biology; Biophysics; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Cell Biology
GA AO0BZ
UT WOS:000340975400022
PM 24882753
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Hasty, AH
   Gruen, ML
   Terry, ES
   Surmi, BK
   Atkinson, RD
   Gao, L
   Morrow, JD
AF Hasty, Alyssa H.
   Gruen, Marnie L.
   Terry, Erin S.
   Surmi, Bonnie K.
   Atkinson, Robin D.
   Gao, Ling
   Morrow, Jason D.
TI Effects of vitamin E on oxidative stress and atherosclerosis in an obese
   hyperlipidemic mouse model
SO JOURNAL OF NUTRITIONAL BIOCHEMISTRY
LA English
DT Article
DE vitamin E; isoprostanes; atherosclerosis; obesity; hyperlipidemia; .
ID LOW-DENSITY-LIPOPROTEIN; ALPHA-TOCOPHEROL SUPPLEMENTATION;
   RECEPTOR-DEFICIENT MICE; METABOLIC SYNDROME; ANTIOXIDANT
   SUPPLEMENTATION; CARDIOVASCULAR-DISEASE; DIETARY ANTIOXIDANTS;
   LIPID-PEROXIDATION; CORONARY-DISEASE; CONTROLLED TRIAL
AB Vitamin E is a natural antioxidant that has been used in animal and human studies to determine its potential in reducing cardiovascular risk; however, a detailed study in an established obese model of atherosclerosis has yet to be performed. In our current study, we show that obesity and hyperlipidemia cause a synergistic, age-related increase in urinary isoprostane levels in mice deficient in both leptin and low-density lipoprotein receptor (ob/ob;LDLR-/-). Based upon this observation, we hypothesized that vitamin E supplementation would induce potent antiatherogenic effects in this model. Lean and obese LDLR-/- mice were provided vitamin E (2000 IU/kg) in a Western-type high-fat diet for 12 weeks. Plasma lipid parameters, such as total cholesterol (TC), triglyceride (TG) and free fatty acid, were significantly higher in obese mice compared to lean mice at baseline (P <.001). Western-type diet (WD) feeding caused an increase in TC levels in all groups (P <.001); however, TG (P <.001) and free fatty acid (P <.01) were elevated only in lean mice following WD feeding. Vitamin E supplementation neither influenced any of these parameters nor reduced urinary isoprostanes in lean or obese mice. Vitamin E supplementation in ob/ob;LDLR-/- mice resulted in a trend toward a reduction in atherosclerotic lesion area (P=.10), although no differences in lesion area were noted in lean LDLR-/- animals. These data provide evidence that vitamin E supplementation is not sufficient to reduce extreme elevations in systemic oxidative stress due to hyperlipidemia and obesity and, thus, may not be cardioprotective in this setting. (c) 2007 Elsevier Inc. All rights reserved.
C1 Vanderbilt Univ, Med Ctr, Dept Physiol & Mol Biophys, Nashville, TN 37232 USA.
   Vanderbilt Univ, Med Ctr, Dept Clin Pharmacol, Nashville, TN 37232 USA.
   Vanderbilt Univ, Med Ctr, Dept Med, Nashville, TN 37232 USA.
C3 Vanderbilt University; Vanderbilt University; Vanderbilt University
RP Hasty, AH (corresponding author), Vanderbilt Univ, Med Ctr, Dept Physiol & Mol Biophys, 221 Kirkland Hall, Nashville, TN 37232 USA.
EM alyssa.hasty@vanderbilt.edu
RI Hasty, Alyssa/AAA-2757-2020
OI Hasty, Alyssa/0000-0001-7302-8045
FU NCI NIH HHS [CA77839] Funding Source: Medline; NCRR NIH HHS [RR00095]
   Funding Source: Medline; NIDDK NIH HHS [DK48831] Funding Source:
   Medline; NIEHS NIH HHS [ES13125] Funding Source: Medline; NIGMS NIH HHS
   [GM15431] Funding Source: Medline
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NR 45
TC 34
Z9 39
U1 0
U2 11
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0955-2863
J9 J NUTR BIOCHEM
JI J. Nutr. Biochem.
PD FEB
PY 2007
VL 18
IS 2
BP 127
EP 133
DI 10.1016/j.jnutbio.2006.03.012
PG 7
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA 129XL
UT WOS:000243763300007
PM 16781857
DA 2025-06-11
ER

PT J
AU Gupta, V
   Santhi, SSE
   Ravi, S
   Ramanan, EA
AF Gupta, Vipul
   Santhi, Sharanya Shre Ezhilarasan
   Ravi, Sailatha
   Ramanan, Ezhil Arasan
TI Rheumatological and Musculoskeletal Complications in Diabetes Patients
SO JOURNAL OF ENDOCRINOLOGY AND METABOLISM
LA English
DT Review
DE Diabetes; Musculoskeletal disorders; Complication; Ear-ly assessment;
   Strict control
ID LIMITED JOINT MOBILITY; GLYCATION END-PRODUCTS; NF-KAPPA-B;
   RHEUMATOID-ARTHRITIS; METABOLIC SYNDROME; CONNECTIVE-TISSUE; SKIN
   COLLAGEN; II DIABETICS; MELLITUS; RISK
AB Musculoskeletal disorders are common in individuals with type 1 dia-betes mellitus (T1DM) or type 2 diabetes mellitus (T2DM). It is asso-ciated with significant morbidity and hampered quality of life. Hyper-glycemia-induced aberrant levels of insulin or insulin growth factors may lead to neuropathic complications, which enhances pain through central sensitization. Evidence suggests that diabetes is associated with numerous musculoskeletal disorders and inefficient control of diabetes may cause persistent musculoskeletal pain over time. Neuro-pathic joints are commonly observed in the foot and ankle of patients. Diabetic polyneuropathy, rheumatoid arthritis (RA)-associated pain are other complications. In diabetic patients with osteoarthritis (OA), factors including advanced glycation end-stage products (AGEs) and markers of oxidative stress could contribute to pain associated with low-grade inflammation. In obese individuals with T2DM, uncon-trolled glycemic status can lead to mechanical stress-induced calci-fication and ossification of ligaments, and oxidative damage. In in-dividuals with diabetes and OA, synovitis in the tissues is evidenced by the presence of higher levels of prostaglandins, leukotrienes, and adipokines. The pathogenesis of cheirarthritis remains largely un-known and is attributed to increased AGE, chronic hyperglycemia, dysregulated function of extracellular and some intracellular proteins. Advancing age, hormonal changes during adolescence, disorderly se-cretion of growth hormone and insulin-like growth factor-1 (IGF-1) are other possible contributing factors. Early assessment and strict control of diabetes can prevent other long-term micro and macrovas-cular complications. These measures can reduce the term of enduring pain and morbidity in susceptible individuals. This article reviews the prevailing knowledge and the mechanistic role of underlying diabetes on rheumatological and musculoskeletal disorders.
C1 [Gupta, Vipul] Gupta Ultrasound & Heart Care Ctr, Delhi 110063, India.
   [Santhi, Sharanya Shre Ezhilarasan] Dr VRE Res Labs, Pulmonol Res, Chennai, Tamil Nadu, India.
   [Ravi, Sailatha] Dr VRE Res Labs, Dept Pharmacogen, Chennai, Tamil Nadu, India.
   [Ramanan, Ezhil Arasan] Dr VRE Res Labs, Chennai, Tamil Nadu, India.
RP Gupta, V (corresponding author), Gupta Ultrasound & Heart Care Ctr, Delhi 110063, India.
EM guptasvipul@hotmail.com
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NR 83
TC 4
Z9 4
U1 0
U2 6
PU ELMER PRESS INC
PI Ontario
PA 9225 LESLIE ST, STE 201, Ontario, RICHMOND HILL, CANADA
SN 1923-2861
EI 1923-287X
J9 J ENDOCRINOL METAB
JI J. Endocrinol. Metab.
PD OCT
PY 2022
VL 12
IS 4-5
BP 117
EP 124
DI 10.14740/jem811
EA SEP 2022
PG 8
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA 8L2VQ
UT WOS:000853687400001
OA gold
DA 2025-06-11
ER

PT J
AU Balamir, I
   Ates, I
   Topcuoglu, C
   Turhan, T
AF Balamir, Ilhan
   Ates, Ihsan
   Topcuoglu, Canan
   Turhan, Turan
TI Association of Endocan, Ischemia-Modified Albumin, and hsCRP Levels With
   Endothelial Dysfunction in Type 2 Diabetes Mellitus
SO ANGIOLOGY
LA English
DT Article
DE diabetes; endocan; endothelial dysfunction; inflammation; oxidative
   stress
ID C-REACTIVE PROTEIN; SUBCLINICAL ATHEROSCLEROSIS; OXIDATIVE STRESS;
   MYOCARDIAL-ISCHEMIA; LIPID-PEROXIDATION; METABOLIC SYNDROME;
   INFLAMMATION; DISEASE; PATHOPHYSIOLOGY; HYPERTENSION
AB We investigated the relationship of ischemia-modified albumin (IMA) and high-sensitivity C-reactive protein (hsCRP) levels with direct (endocan) and indirect (carotid intima-media thickness [cIMT] and 24 hours urine protein excretion) endothelial dysfunction indicators in type 2 diabetes mellitus (T2DM). Patients with T2DM (n = 88) and 88 healthy individuals were included in the study. The median endocan (475.15 vs 216.37 pg/mL; P < .001, respectively) and hsCRP (10.74 vs 3.11 mg/L; P < .001, respectively) and the mean IMA (0.64 +/- 0.12 vs 0.51 +/- 0.12 absorbance units; P < .001, respectively) levels were higher in participants with endothelial dysfunction compared to those without endothelial dysfunction in T2DM. The 24-hour urine protein excretion and cIMT levels had a positive correlation with hsCRP (r = .357; P = .001 and r = .592; P < .001, respectively), IMA (r = .519; P < .001 and r = .495; P < .001, respectively) and endocan (r = .347; P = .001 and r = .583; P < .001, respectively) levels in the T2DM group. Stepwise multivariable logistic regression analysis, which included laboratory findings found to be associated with endothelial dysfunction, showed that endocan (odds ratio [OR] = 1.456; P = .004), hsCRP (OR = 1.298; P = .008), and IMA (OR = 2.270, P = .003) were independent risk factors. It was found that none of these markers were superior in terms of diagnostic discrimination for endothelial dysfunction. Endocan, IMA, and hsCRP levels were found to be associated with endothelial dysfunction in patients with T2DM.
C1 [Balamir, Ilhan; Topcuoglu, Canan; Turhan, Turan] Ankara Numune Training & Res Hosp, Dept Biochem, TR-06100 Ankara, Turkey.
   [Ates, Ihsan] Ankara Numune Training & Res Hosp, Dept Internal Med, Ankara, Turkey.
C3 Ankara Numune Training & Research Hospital; Ankara Numune Training &
   Research Hospital
RP Balamir, I (corresponding author), Ankara Numune Training & Res Hosp, Dept Biochem, TR-06100 Ankara, Turkey.
EM dr.ilhanbalamir@hotmail.com
RI Balamir, İlhan/HKV-0737-2023; turhan, turan/CAH-5850-2022; ateş,
   ihsan/ABG-8202-2021
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NR 46
TC 41
Z9 42
U1 0
U2 10
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0003-3197
EI 1940-1574
J9 ANGIOLOGY
JI Angiology
PD AUG
PY 2018
VL 69
IS 7
BP 609
EP 616
DI 10.1177/0003319717740781
PG 8
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA GM9GG
UT WOS:000438553800008
PM 29172652
DA 2025-06-11
ER

PT J
AU Alexandre, EC
   Calmasini, FB
   de Oliveira, MG
   Silva, FH
   da Silva, CPV
   André, DM
   Leonardo, FC
   Delbin, MA
   Antunes, E
AF Alexandre, Eduardo C.
   Calmasini, Fabiano B.
   de Oliveira, Mariana G.
   Silva, Fabio H.
   da Silva, Carmem P. V.
   Andre, Diana M.
   Leonardo, Flavia C.
   Delbin, Maria A.
   Antunes, Edson
TI Chronic treatment with resveratrol improves overactive bladder in obese
   mice via antioxidant activity
SO EUROPEAN JOURNAL OF PHARMACOLOGY
LA English
DT Article
DE Cystometry; gp91phox; NADPH oxidase; Obesity; Reactive-oxygen species;
   Superoxide dismutase
ID URINARY-TRACT SYMPTOMS; ACTIVATOR BAY 60-2770; OXIDATIVE STRESS; NADPH
   OXIDASE; ERECTILE DYSFUNCTION; METABOLIC SYNDROME; TNF-ALPHA;
   RESTRICTION; ISCHEMIA; HEALTH
AB The objective of the present work was to evaluate whether oral intake with resveratrol ameliorates overactive bladder in high-fat fed mice. Male C57BL6 mice fed with standard chow or high-fat diet to induce obesity received a two-week therapy with resveratrol (100 mg/kg, given as a daily gavage). Weight and metabolic profile, together with cystometry and in vitro bladder contractions were evaluated. Measurements of gp91phox and SOD1 mRNA expressions and reactive-oxygen species (ROS) in bladder tissues, and serum TBARS were performed. Obese mice exhibited increases in body weight and epididymal fat mass, which were significantly reduced by oral treatment with resveratrol. Cystometric study in obese mice showed increases in non-voiding contractions, post-voiding pressure and voiding frequency that were reversed by resveratrol treatment. Likewise, the in vitro bladder overactivity in response to electrical-field stimulation (80 V, 1-32 Hz) or carbachol (1 nM to 10 mM) were normalized by resveratrol. The gp91phox and SOD1 mRNA expressions in bladder tissues were markedly higher in obese mice compared with lean group. In addition, ROS levels in bladder tissues and serum lipid per oxidation (TBARS assay) were markedly higher in obese compared with lean mice, all of which were reduced by resveratrol treatment. In lean group, resveratrol had no effect in any parameter evaluated. Our results show that two-week therapy of obese mice with resveratrol reduces the systemic and bladder oxidative stress, and greatly ameliorated the cystometry alterations and in vitro bladder overactivity. Resveratrol treatment could be an option to prevent obesity-associated overactive bladder. (C) 2016 Elsevier B.V. All rights reserved.
C1 [Alexandre, Eduardo C.; Calmasini, Fabiano B.; de Oliveira, Mariana G.; Andre, Diana M.; Antunes, Edson] Univ Campinas UNICAMP, Fac Med Sci, Dept Pharmacol, BR-13084971 Campinas, SP, Brazil.
   [da Silva, Carmem P. V.; Delbin, Maria A.] Univ Campinas UNICAMP, Inst Biol, Dept Struct & Funct Biol, BR-13083862 Campinas, SP, Brazil.
   [Silva, Fabio H.; Leonardo, Flavia C.] Univ Campinas UNICAMP, Hematol & Hemotherapy Ctr, BR-13083878 Campinas, SP, Brazil.
C3 Universidade Estadual de Campinas; Universidade Estadual de Campinas;
   Universidade Estadual de Campinas
RP Antunes, E (corresponding author), Univ Campinas UNICAMP, Fac Med Sci, Dept Pharmacol, BR-13084971 Campinas, SP, Brazil.
EM edson.antunes@uol.com.br
RI Antunes, Edson/KRP-5678-2024; Delbin, Maria/F-4233-2012; SILVA,
   FABIO/AAZ-8140-2020; Alexandre, Eduardo/D-3797-2013; André,
   Diana/N-3160-2013; Calmasini, Fabiano/S-9691-2019; ANTUNES,
   EDSON/F-6731-2012; Silva, Fabio/D-5412-2013; de Oliveira, Mariana
   G/D-2059-2016
OI ANTUNES, EDSON/0000-0003-2201-8247; Beraldi Calmasini,
   Fabiano/0000-0002-7790-2550; Delbin, Maria/0000-0002-3537-055X; Silva,
   Fabio/0000-0003-3374-5570; de Oliveira, Mariana G/0000-0003-2226-2530
FU Sao Paulo Research Foundation [FAPESP 2014/02196-2]; Fundacao de Amparo
   a Pesquisa do Estado de Sao Paulo (FAPESP) [14/02196-2] Funding Source:
   FAPESP
FX Eduardo Costa Alexandre and Edson Antunes are grateful to Sao Paulo
   Research Foundation (FAPESP 2014/02196-2) for financial support.
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NR 35
TC 27
Z9 27
U1 0
U2 12
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0014-2999
EI 1879-0712
J9 EUR J PHARMACOL
JI Eur. J. Pharmacol.
PD OCT 5
PY 2016
VL 788
BP 29
EP 36
DI 10.1016/j.ejphar.2016.06.017
PG 8
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA DX0XD
UT WOS:000384088800004
PM 27316789
DA 2025-06-11
ER

PT J
AU Rabádan-Chávez, GM
   Reyes-Maldonado, E
   Quevedo-Corona, L
   Paniagua-Castro, N
   Escalona-Cardoso, G
   Jaramillo-Flores, ME
AF Rabadan-Chavez, G. M.
   Reyes-Maldonado, E.
   Quevedo-Corona, L.
   Paniagua-Castro, N.
   Escalona-Cardoso, G.
   Jaramillo-Flores, M. E.
TI The prothrombotic state associated with obesity-induced hypertension is
   reduced by cocoa and its main flavanols
SO FOOD & FUNCTION
LA English
DT Article
ID PLASMINOGEN-ACTIVATOR INHIBITOR-1; ENDOTHELIAL FUNCTION; BLOOD-PRESSURE;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; NITRIC-OXIDE; OXIDATIVE STRESS;
   LIVER STEATOSIS; DYSFUNCTION; MECHANISMS
AB Background. Little is known about the effects of cocoa and its main flavanols on the prothrombotic state associated with the development of hypertension in diet-induced obesity models. Purpose. To evaluate the effects of cocoa powder, cocoa extract and their main flavanols on plasma biomarkers related to impaired coagulation and fibrinolysis and its association with hypertension and obesity-related metabolic disorders in rats fed a hypercaloric diet. Methods. Male Wistar rats were randomly assigned to 7 treatment groups (n = 7): normal diet (ND); hypercaloric diet control group (HCD); HCD + cocoa powder (CO); HCD + cocoa extract (CO-EX); HCD + (-)-epicatechin (EPI); HCD + (+)-catechin (CAT); and HCD + procyanidin B2 (PB2). Blood pressure was measured using the tail-cuff method (week 7). At the end of the experimental period (week 8), rats were sacrificed and blood samples were collected immediately for coagulation and biochemical analyses. Results. Oral administration of CO, CO-EX and their main flavanols significantly decreased plasma biomarkers related to impaired coagulation and fibrinolysis (vWF, FVIII, fibrinogen and PAI-1) in rats fed a hypercaloric diet. These effects were associated with decreased systolic and diastolic blood pressure, aortic oxidative stress (MDA levels) and improvement of dyslipidemia, insulin resistance and circulating markers of inflammation (TNF-alpha, IL-6 and CRP) compared to the HCD group. Conclusion. Our results showed that cocoa and its main flavanols may improve endothelial dysfunction and exert their antihypertensive effects by decreasing the prothrombotic state in rats fed a hypercaloric diet. Moreover, improvement of obesity-related metabolic disorders may also contribute to their BP-lowering effect.
C1 [Rabadan-Chavez, G. M.; Reyes-Maldonado, E.; Quevedo-Corona, L.; Paniagua-Castro, N.; Escalona-Cardoso, G.; Jaramillo-Flores, M. E.] Inst Politecn Nacl, Escuela Nacl Ciencias Biol, Unidad Profes Adolfo Lopez Mateos, Wilfrido Massiew S-N Esq, Ciudad De Mexico 07738, Mexico.
C3 Instituto Politecnico Nacional - Mexico
RP Jaramillo-Flores, ME (corresponding author), Inst Politecn Nacl, Escuela Nacl Ciencias Biol, Unidad Profes Adolfo Lopez Mateos, Wilfrido Massiew S-N Esq, Ciudad De Mexico 07738, Mexico.
EM gris.rab@gmail.com; elbareyesm@gmail.com; quevedocorona@hotmail.com;
   npaniag@hotmail.com; Jaramillo_flores@hotmail.com
OI JARAMILLO FLORES, MARIA EUGENIA/0000-0002-0351-5339
FU Mexican National Council for Science and Technology (CONACYT);  [SIP-IPN
   20160499];  [CONACYT-CB-2013-01];  [220732-I010/532/2014]
FX This work was financially supported through the project SIP-IPN
   20160499; CONACYT-CB-2013-01 no. 220732-I010/532/2014. The first author
   thanks the Mexican National Council for Science and Technology (CONACYT)
   for the Ph.D. grant provided.
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NR 78
TC 16
Z9 17
U1 0
U2 11
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PY 2016
VL 7
IS 12
BP 4880
EP 4888
DI 10.1039/c6fo01165a
PG 9
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA EM5TJ
UT WOS:000395375900016
PM 27827474
DA 2025-06-11
ER

PT J
AU Virmani, A
   Pinto, L
   Bauermann, O
   Zerelli, S
   Diedenhofen, A
   Binienda, ZK
   Ali, SF
   van der Leij, FR
AF Virmani, Ashraf
   Pinto, Luigi
   Bauermann, Otto
   Zerelli, Saf
   Diedenhofen, Andreas
   Binienda, Zbigniew K.
   Ali, Syed F.
   van der Leij, Feike R.
TI The Carnitine Palmitoyl Transferase (CPT) System and Possible Relevance
   for Neuropsychiatric and Neurological Conditions
SO MOLECULAR NEUROBIOLOGY
LA English
DT Article
DE Oxidative phosphorylation; AMP-activated; protein kinase; Nutrition;
   Malonyl-CoA; Metabolic-cognitive syndrome
ID FATTY-ACID-METABOLISM; ENDOPLASMIC-RETICULUM STRESS; ACETYL-L-CARNITINE;
   PALMITOYLTRANSFERASE-I; INSULIN-RESISTANCE; MITOCHONDRIAL DYSFUNCTION;
   VASCULAR DEMENTIA; OXIDATIVE STRESS; BETA-OXIDATION; MALONYL-COA
AB The carnitine palmitoyl transferase (CPT) system is a multiprotein complex with catalytic activity localized within a core represented by CPT1 and CPT2 in the outer and inner membrane of the mitochondria, respectively. Two proteins, the acyl-CoA synthase and a translocase also form part of this system. This system is crucial for the mitochondrial beta-oxidation of long-chain fatty acids. CPT1 has two well-known isoforms, CPT1a and CPT1b. CPT1a is the hepatic isoform and CPT1b is typically muscular; both are normally utilized by the organism for metabolic processes throughout the body. There is a strong evidence for their involvement in various disease states, e.g., metabolic syndrome, cardiovascular diseases, and in diabetes mellitus type 2. Recently, a new, third isoform of CPT was described, CPT1c. This is a neuronal isoform and is prevalently localized in brain regions such as hypothalamus, amygdala, and hippocampus. These brain regions play an important role in control of food intake and neuropsychiatric and neurological diseases. CPT activity has been implicated in several neurological and social diseases mainly related to the alteration of insulin equilibrium in the brain. These pathologies include Parkinson's disease, Alzheimer's disease, and schizophrenia. Evolution of both Parkinson's disease and Alzheimer's disease is in some way linked to brain insulin and related metabolic dysfunctions with putative links also with the diabetes type 2. Studies show that in the CNS, CPT1c affects ceramide levels, endocannabionoids, and oxidative processes and may play an important role in various brain functions such as learning.
C1 [Virmani, Ashraf; Pinto, Luigi; Bauermann, Otto; Zerelli, Saf] Sigma Tau Hlth Sci Int BV, Res Innovat & Dev, Utrecht, Netherlands.
   [Virmani, Ashraf; Pinto, Luigi; Bauermann, Otto; Diedenhofen, Andreas] Sigma Tau Pharmaceut Co, Pomezia, Rome, Italy.
   [Binienda, Zbigniew K.] US FDA, Neurophysiol Lab, Natl Ctr Toxicol Res, Jefferson, AR 72079 USA.
   [Ali, Syed F.] US FDA, Neurochem Lab, Div Neurotoxicol, Natl Ctr Toxicol Res, Jefferson, AR 72079 USA.
   [van der Leij, Feike R.] Van Hall Larenstein & NHL Univ Appl Sci, NL-8901 BV Leeuwarden, Netherlands.
C3 Leadiant Biosciences; US Food & Drug Administration (FDA); US Food &
   Drug Administration (FDA)
RP Virmani, A (corresponding author), Sigma Tau Hlth Sci Int BV, Res Innovat & Dev, Utrecht, Netherlands.
EM ashraf.virmani@sigma-tau.it
RI Virmani, a./J-9790-2019
OI van der Leij, Feike/0000-0001-6702-403X
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NR 87
TC 49
Z9 52
U1 2
U2 30
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0893-7648
EI 1559-1182
J9 MOL NEUROBIOL
JI Mol. Neurobiol.
PD OCT
PY 2015
VL 52
IS 2
SI SI
BP 826
EP 836
DI 10.1007/s12035-015-9238-7
PG 11
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA CQ6AQ
UT WOS:000360687200003
PM 26041663
DA 2025-06-11
ER

PT J
AU Bai, ZZ
   Tana, WR
   Liu, S
   Han, SR
   Chen, L
   McClain, D
   Ge, RL
AF Bai, Zhenzhong
   Tana Wuren
   Liu, Shou
   Han, Shirui
   Chen, Lin
   McClain, Donald
   Ge, Ri-Li
TI Intermittent cold exposure results in visceral adipose tissue "browning"
   in the plateau pika (Ochotona curzoniae)
SO COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE
   PHYSIOLOGY
LA English
DT Article
DE Intermitted cold exposure; Plateau pika; Adaptation; White adipose
   tissues; Browning; Visceral fat
ID PPAR-GAMMA ACTIVATION; ALTITUDE DEER MICE; METABOLIC SYNDROME; OBESITY;
   EXPRESSION; FAT; THERMOGENESIS; ADAPTATION; STRESS; HUMANS
AB The plateau pika has developed tolerance to cold and hypoxia in order to adapt to living in the extreme environment of the Qinghai-Tibetan Plateau. One mammalian mechanism for cold adaptation is thermogenesis by brown adipose tissue (BAT), but the degree to which pika exploits this mechanism or how it may be modified by the additional stresses of high altitude is not known. Intermittent Cold Exposure (ICE) is an approachable method to study cold adaptation in rodents. To investigate the role of adipose tissue in the adaptation of pika to cold temperatures, we have studied pika during ICE. We find that pika kept in warm temperatures has little classical brown fat, but "browning" of white adipose tissues is observed rapidly upon cold exposure. This is demonstrated by the increased expression of several markers of brown fat differentiation including uncoupling protein 1 (UCP1). Surprisingly, this occurs mainly in visceral rather than epididymal adipose tissue. In addition, ICE increases the expression of several general adipose differentiation markers at both the mRNA and protein levels. These substantial changes in the distribution of fat are accomplished without changes in weight or blood levels of glucose and triglycerides, suggesting that the adaptable changes are coordinated and self-compensated. Together, our results demonstrate that ICE promotes recruitment of BAT in pika, and unlike small mammals in at lower altitudes, pika can activate visceral WAT to adapt to cold stress without major changes overall energy balance. (C) 2015 Elsevier Inc. All rights reserved.
C1 [Bai, Zhenzhong; Tana Wuren; Liu, Shou; Han, Shirui; Chen, Lin; Ge, Ri-Li] Qinghai Univ, Sch Med, Qinghai Utah Joint Res Key Llab High Altitude Med, Xining 810001, Qinghai, Peoples R China.
   [McClain, Donald] Univ Utah, Sch Med, Dept Internal Med, Salt Lake City, UT 84112 USA.
C3 Qinghai University; Utah System of Higher Education; University of Utah
RP McClain, D (corresponding author), Univ Utah, Sch Med, Dept Internal Med, Salt Lake City, UT 84112 USA.
EM geriligao@hotmail.com
OI McClain, Don/0000-0002-3310-2359
FU National Basic Research Program of China [2012CB518200]; Program of
   International S&T Cooperation of China [0S2012GR0195]; National Natural
   Science Foundation of China [30393133]
FX This work was supported by the: National Basic Research Program of China
   (No. 2012CB518200),Program of International S&T Cooperation of China
   (No. 0S2012GR0195), and National Natural Science Foundation of China
   (No. 30393133).
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NR 38
TC 29
Z9 32
U1 0
U2 40
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1095-6433
EI 1531-4332
J9 COMP BIOCHEM PHYS A
JI Comp. Biochem. Physiol. A-Mol. Integr. Physiol.
PD JUN
PY 2015
VL 184
BP 171
EP 178
DI 10.1016/j.cbpa.2015.01.019
PG 8
WC Biochemistry & Molecular Biology; Physiology; Zoology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Physiology; Zoology
GA CH0WM
UT WOS:000353743100022
PM 25662677
DA 2025-06-11
ER

PT J
AU Silva, TS
   da Costa, AMR
   Conceiçao, LEC
   Dias, JP
   Rodrigues, PML
   Richard, N
AF Silva, Tome S.
   da Costa, Ana M. R.
   Conceicao, Luis E. C.
   Dias, Jorge P.
   Rodrigues, Pedro M. L.
   Richard, Nadege
TI Metabolic fingerprinting of gilthead seabream (Sparus aurata)
   liver to track interactions between dietary factors and seasonal
   temperature variations
SO PEERJ
LA English
DT Article
DE Aquaculture; Gilthead seabream; Liver; Metabolomics; Winter disease;
   Winter syndrome; Thermal stress; Metabolic fingerprinting; Vibrational
   spectroscopy; FT-IR
ID RAINBOW-TROUT LIVER; SEA BREAM; WINTER SYNDROME; FT-IR; SPECTROSCOPIC
   ANALYSIS; ARSENIC INTOXICATION; MICRODIET INGESTION; LABEO-ROHITA;
   TISSUE; LARVAE
AB Farmed gilthead seabream is sometimes affected by a metabolic syndrome, known as the "winter disease", which has a significant economic impact in the Mediterranean region. It is caused, among other factors, by the thermal variations that occur during colder months and there are signs that an improved nutritional status can mitigate the effects of this thermal stress. For this reason, a trial was undertaken where we assessed the effect of two different diets on gilthead seabream physiology and nutritional state, through metabolic fingerprinting of hepatic tissue. For this trial, four groups of 25 adult gilthead seabream were reared for 8 months, being fed either with a control diet (CTRL, low-cost commercial formulation) or with a diet called "Winter Feed" (WF, high-cost improved formulation). Fish were sampled at two time-points (at the end of winter and at the end of spring), with liver tissue being taken for FT-IR spectroscopy. Results have shown that seasonal temperature variations constitute a metabolic challenge for gilthead seabream, with hepatic carbohydrate stores being consumed over the course of the inter-sampling period. Regarding the WF diet, results point towards a positive effect in terms of performance and improved nutritional status. This diet seems to have a mitigating effect on the deleterious impact of thermal shifts, confirming the hypothesis that nutritional factors can affect the capacity of gilthead seabream to cope with seasonal thermal variations and possibly contribute to prevent the onset of "winter disease".
C1 [Silva, Tome S.; Conceicao, Luis E. C.; Dias, Jorge P.] SPAROS Lda, Olhao, Portugal.
   [Silva, Tome S.; Rodrigues, Pedro M. L.; Richard, Nadege] Univ Algarve, Ctr Marine Sci Algarve, CCMAR, Faro, Portugal.
   [da Costa, Ana M. R.] Univ Algarve, Algarve Chem Res Ctr, CIQA, Faro, Portugal.
   [da Costa, Ana M. R.; Rodrigues, Pedro M. L.] Univ Algarve, Dept Chem & Pharm, Faro, Portugal.
C3 Universidade do Algarve; Universidade do Algarve; Universidade do
   Algarve
RP Silva, TS (corresponding author), SPAROS Lda, Olhao, Portugal.
EM tome@tomesilva.com
RI Conceicao, Luis/I-3037-2013; Dias, Jorge/A-2820-2012; Richard,
   Nadege/M-3385-2013; Rosa da Costa, Ana M/E-2165-2012; Conceicao,
   Luis/H-6257-2011; Rodrigues, Pedro/M-3406-2013
OI Richard, Nadege/0000-0002-8983-0726; Rosa da Costa, Ana
   M/0000-0003-0225-9537; Conceicao, Luis/0000-0001-6102-2068; Rodrigues,
   Pedro/0000-0002-9668-1204; Silva, Tome/0000-0002-9434-8686; Dias,
   Jorge/0000-0003-2796-2624
FU FEDER through PO Algarve 21; Portuguese Foundation for Science and
   Technology (FCT) [SFRH/BDP/65578/2009];  [21595-INUTR]
FX This work is part of project 21595-INUTR, co-financed by FEDER through
   PO Algarve 21, in the framework of QREN 2007-2013. Nadege Richard
   received a post-doctoral grant (SFRH/BDP/65578/2009) from the Portuguese
   Foundation for Science and Technology (FCT). The funders had no role in
   study design, data collection and analysis, decision to publish, or
   preparation of the manuscript.
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NR 37
TC 28
Z9 30
U1 1
U2 41
PU PEERJ INC
PI LONDON
PA 341-345 OLD ST, THIRD FLR, LONDON, EC1V 9LL, ENGLAND
SN 2167-8359
J9 PEERJ
JI PeerJ
PD AUG 26
PY 2014
VL 2
AR e527
DI 10.7717/peerj.527
PG 19
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA AY5NE
UT WOS:000347618300002
PM 25210655
OA gold, Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Giris, M
   Dogru-Abbasoglu, S
   Kumral, A
   Olgaç, V
   Koçak-Toker, N
   Uysal, M
AF Giris, Murat
   Dogru-Abbasoglu, Semra
   Kumral, Alkin
   Olgac, Vakur
   Kocak-Toker, Necla
   Uysal, Mujdat
TI Effect of carnosine alone or combined with α-tocopherol on hepatic
   steatosis and oxidative stress in fructose-induced insulin-resistant
   rats
SO JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
LA English
DT Article; Proceedings Paper
CT 10th Meeting of the Contribution To Progress in Obesity and Diabetes
   Research (CTPIOD)
CY MAY 22, 2013
CL Reus, SPAIN
DE Carnosine; alpha-Tocopherol; Insulin resistance; Hepatic oxidative
   stress; High fructose diet
ID METABOLIC SYNDROME; DIETARY CARNOSINE; LIPID-METABOLISM; LIVER-INJURY;
   LIPOIC ACID; HISTIDINE; SUPPLEMENTATION; LIPOPROTEINS; CURCUMIN; TISSUES
AB A diet high in fructose (HFr) induces insulin resistance in animals. Free radicals are involved in the pathogenesis of HFr-induced insulin resistance. Carnosine (CAR) is a dipeptide with antioxidant properties. We investigated the effect of CAR alone or in combination with a-tocopherol (CAR+TOC) on HFr-induced insulin-resistant rats. Rats fed with HFr containing 60 % fructose received CAR (2 g/L in drinking water) with/without TOC (200 mg/kg, i.m. twice a week) for 8 weeks. Insulin resistance, serum lipids, inflammation markers, hepatic lipids, lipid peroxides, and glutathione (GSH) levels together with glutathione peroxidase (GSH-Px) and superoxide dismutase 1 (CuZnSOD; SOD1) activities and their protein expressions were measured. Hepatic histopathological examinations were performed. HFr was observed to cause insulin resistance, inflammation and hypertriglyceridemia, and increased triglyceride and lipid peroxide levels in the liver. GSH-Px activity and expression decreased, but GSH levels and SOD1 activity and expression did not alter in HFr rats. Hepatic marker enzyme activities in serum increased and marked macro-and microvesicular steatosis were seen in the liver. CAR treatment did not alter insulin resistance and hypertriglyceridemia, but it decreased steatosis and lipid peroxidation without any change in the antioxidant system of the liver. However, CAR+TOC treatment decreased insulin resistance, inflammation, hepatic steatosis, and lipid peroxidation and increased GSH-Px activity and expression in the liver. Our results may indicate that CAR+ TOC treatment is more effective to decrease HFr-induced insulin resistance, inflammation, hepatic steatosis, and dysfunction and pro-oxidant status in rats than CAR alone.
C1 [Giris, Murat] Istanbul Univ, Inst Expt Med, Dept Neurosci, Istanbul, Turkey.
   [Dogru-Abbasoglu, Semra; Kumral, Alkin; Kocak-Toker, Necla; Uysal, Mujdat] Istanbul Univ, Istanbul Fac Med, Dept Biochem, Istanbul, Turkey.
   [Olgac, Vakur] Istanbul Univ, Inst Oncol, Dept Pathol, Istanbul, Turkey.
C3 Istanbul University; Istanbul University; Istanbul University
RP Dogru-Abbasoglu, S (corresponding author), Istanbul Univ, Istanbul Fac Med, Dept Biochem, Istanbul, Turkey.
EM sdabbasoglu@yahoo.com
RI Giriş, Murat/JHT-8513-2023; Kocak-Toker, Necla/AAD-8944-2020; Abbasoglu,
   Semra/AAD-9014-2020
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NR 48
TC 35
Z9 39
U1 2
U2 3
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1138-7548
EI 1877-8755
J9 J PHYSIOL BIOCHEM
JI J. Physiol. Biochem.
PD JUN
PY 2014
VL 70
IS 2
BP 385
EP 395
DI 10.1007/s13105-014-0314-7
PG 11
WC Biochemistry & Molecular Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Biochemistry & Molecular Biology; Physiology
GA AG4GN
UT WOS:000335377500010
PM 24464863
DA 2025-06-11
ER

PT J
AU Chuang, HC
   Chou, CC
   Kulp, SK
   Chen, CS
AF Chuang, Hsiao-Ching
   Chou, Chih-Chien
   Kulp, Samuel K.
   Chen, Ching-Shih
TI AMPK as a Potential Anticancer Target - Friend or Foe?
SO CURRENT PHARMACEUTICAL DESIGN
LA English
DT Article
DE AMPK; metabolic homeostasis; cancer therapy; LKB1; mTORC1; HDAC; Foxo3a;
   HIF-1 alpha
ID ACTIVATED PROTEIN-KINASE; DOUBLE-EDGED-SWORD; GENE-EXPRESSION;
   ENERGY-SENSOR; PROSTATE-CANCER; TRANSCRIPTIONAL ACTIVITY;
   SKELETAL-MUSCLE; CELL-GROWTH; DIRECT PHOSPHORYLATION; LKB1-AMPK PATHWAY
AB Adenosine monophosphate-activated protein kinase (AMPK) is a key player in maintaining energy homeostasis in response to metabolic stress. Beyond diabetes and metabolic syndrome, there is a growing interest in the therapeutic exploitation of the AMPK pathway in cancer treatment in light of its unique ability to regulate cancer cell proliferation through the reprogramming of cell metabolism. Although many studies support the tumor-suppressive role of AMPK, emerging evidence suggests that the metabolic checkpoint function of AMPK might be overridden by stress or oncogenic signals so that tumor cells use AMPK activation as a survival strategy to gain growth advantage. These findings underscore the complexity in the cellular function of AMPK in maintaining energy homeostasis under physiological versus pathological conditions. Thus, this review aims to provide an overview of recent findings on the functional interplay of AMPK with different cell metabolic and signaling effectors, particularly histone deacetylases, in mediating downstream tumor suppressive or promoting mechanisms in different cell systems. Although AMPK activation inhibits tumor growth by targeting multiple signaling pathways relevant to tumorigenesis, under certain cellular contexts or certain stages of tumor development, AMPK might act as a protective response to metabolic stresses, such as nutrient deprivation, low oxygen, and low pH, or as downstream effectors of oncogenic proteins, including androgen receptor, hypoxia-inducible factor-1 alpha, c-Src, and MYC. Thus, investigations to define at which stage(s) of tumorigenesis and cancer progression or for which genetic aberrations AMPK inhibition might represent a more relevant strategy than AMPK activation for cancer treatment are clearly warranted.
C1 [Chuang, Hsiao-Ching; Chou, Chih-Chien; Kulp, Samuel K.; Chen, Ching-Shih] Ohio State Univ, Div Med Chem, Coll Pharm, Columbus, OH 43210 USA.
   [Chuang, Hsiao-Ching; Chou, Chih-Chien; Kulp, Samuel K.; Chen, Ching-Shih] Ohio State Univ, Ctr Comprehens Canc, Columbus, OH 43210 USA.
   [Chen, Ching-Shih] Natl Cheng Kung Univ, Inst Basic Med Sci, Tainan 70101, Taiwan.
C3 University System of Ohio; Ohio State University; James Cancer Hospital
   & Solove Research Institute; University System of Ohio; Ohio State
   University; National Cheng Kung University
RP Chen, CS (corresponding author), Ohio State Univ, Coll Pharm, Rm 336,Pk Hall,500 W 12th Ave, Columbus, OH 43210 USA.
EM chen.844@osu.edu
RI Huang, Chun-Feng/KAO-3236-2024
FU National Cancer Institute [R01CA112250, R21CA158807]
FX This work was supported by Public Health Service Grants R01CA112250 and
   R21CA158807 from the National Cancer Institute.
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NR 135
TC 44
Z9 45
U1 1
U2 15
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1381-6128
EI 1873-4286
J9 CURR PHARM DESIGN
JI Curr. Pharm. Design
PD MAY
PY 2014
VL 20
IS 15
BP 2607
EP 2618
DI 10.2174/13816128113199990485
PG 12
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA AH5KX
UT WOS:000336169300015
PM 23859619
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Najjar, SM
   Ledford, KJ
   Abdallah, SL
   Paus, A
   Russo, L
   Kaw, MK
   Ramakrishnan, SK
   Muturi, HT
   Raphael, CK
   Lester, SG
   Heinrich, G
   Pierre, SV
   Benndorf, R
   Kleff, V
   Jaffa, AA
   Lévy, E
   Vazquez, G
   Goldberg, IJ
   Beauchemin, N
   Scalia, R
   Ergün, S
AF Najjar, Sonia M.
   Ledford, Kelly J.
   Abdallah, Simon L.
   Paus, Alexander
   Russo, Lucia
   Kaw, Meenakshi K.
   Ramakrishnan, Sadeesh K.
   Muturi, Harrison T.
   Raphael, Christian K.
   Lester, Sumona Ghosh
   Heinrich, Garrett
   Pierre, Sandrine V.
   Benndorf, Ralf
   Kleff, Veronika
   Jaffa, Ayad A.
   Levy, Emile
   Vazquez, Guillermo
   Goldberg, Ira J.
   Beauchemin, Nicole
   Scalia, Rosario
   Erguen, Sueleyman
TI Ceacam1 deletion causes vascular alterations in large vessels
SO AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
LA English
DT Article
DE NEFA; metabolic syndrome; obesity; fatty liver disease
ID CELL-ADHESION MOLECULE-1; NITRIC-OXIDE SYNTHASE; NECROSIS-FACTOR-ALPHA;
   ENDOTHELIAL-CELL; OXIDATIVE STRESS; INSULIN-RECEPTOR; BETA-CATENIN;
   EXPRESSION; ATHEROSCLEROSIS; INFLAMMATION
AB Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) promotes hepatic insulin clearance and endothelial survival. However, its role in the morphology of macrovessels remains unknown. Mice lacking Ceacam1 (Cc1(-/-)) exhibit hyperinsulinemia, which causes insulin resistance and fatty liver. With increasing evidence of an association among hyperinsulinemia, fatty liver disease, and atherosclerosis, we investigated whether Cc1(-/-) exhibited vascular lesions in atherogenicprone aortae. Histological analysis revealed impaired endothelial integrity with restricted fat deposition and aortic plaque-like lesions in Cc1(-/-) aortae, likely owing to their limited lipidemia. Immunohistochemical analysis indicated macrophage deposition, and in vitro studies showed increased leukocyte adhesion to aortic wall, mediated in part by elevation in vascular cell adhesion molecule 1 levels. Basal aortic eNOS protein and NO content were reduced, in parallel with reduced Akt/eNOS and Akt/Foxo1 phosphorylation. Ligand-induced vasorelaxation was compromised in aortic rings. Increased NADPH oxidase activity and plasma 8-isoprostane levels revealed oxidative stress and lipid peroxidation in Cc1(-/-) aortae. siRNA-mediated CEACAM1 knockdown in bovine aortic endothelial cells adversely affected insulin's stimulation of IRS-1/PI 3-kinase/Akt/eNOS activation by increasing IRS-1 binding to SHP2 phosphatase. This demonstrates that CEACAM1 regulates both endothelial cell autonomous and nonautonomous mechanisms involved in vascular morphology and NO production in aortae. Systemic factors such as hyperinsulinemia could contribute to the pathogenesis of these vascular abnormalities. Cc1(-/-) mice provide a first in vivo demonstration of distinct CEACAM1-dependent hepatic insulin clearance linking hepatic to macrovascular abnormalities.
C1 [Najjar, Sonia M.; Ledford, Kelly J.; Abdallah, Simon L.; Russo, Lucia; Kaw, Meenakshi K.; Ramakrishnan, Sadeesh K.; Muturi, Harrison T.; Raphael, Christian K.; Lester, Sumona Ghosh; Heinrich, Garrett; Pierre, Sandrine V.; Vazquez, Guillermo] Univ Toledo, Coll Med & Life Sci, Ctr Diabet & Endocrine Res, Toledo, OH 43614 USA.
   [Najjar, Sonia M.; Ledford, Kelly J.; Abdallah, Simon L.; Russo, Lucia; Kaw, Meenakshi K.; Ramakrishnan, Sadeesh K.; Muturi, Harrison T.; Raphael, Christian K.; Lester, Sumona Ghosh; Heinrich, Garrett; Pierre, Sandrine V.; Vazquez, Guillermo] Univ Toledo, Coll Med & Life Sci, Dept Physiol & Pharmacol, Toledo, OH 43614 USA.
   [Paus, Alexander; Kleff, Veronika; Erguen, Sueleyman] Univ Duisburg, Inst Anat, Essen, Germany.
   [Benndorf, Ralf; Erguen, Sueleyman] Univ Wurzburg, Inst Anat & Cell Biol Julius Maximilians, D-97070 Wurzburg, Germany.
   [Jaffa, Ayad A.] Amer Univ Beirut, Fac Med, Dept Biochem & Mol Genet, Beirut, Lebanon.
   [Levy, Emile] Ste Justine Hosp, Res Ctr, Dept Nutr, Montreal, PQ, Canada.
   [Levy, Emile] Univ Montreal, Montreal, PQ, Canada.
   [Goldberg, Ira J.] Columbia Univ, Div Prevent Med & Nutr, New York, NY USA.
   [Beauchemin, Nicole] McGill Univ, Goodman Canc Res Ctr, Montreal, PQ, Canada.
   [Scalia, Rosario] Temple Univ, Sch Med, Dept Physiol, Philadelphia, PA 19122 USA.
   [Scalia, Rosario] Temple Univ, Sch Med, Cardiovasc Res Ctr, Philadelphia, PA 19122 USA.
C3 University System of Ohio; University of Toledo; University System of
   Ohio; University of Toledo; University of Duisburg Essen; University of
   Wurzburg; American University of Beirut; Universite de Montreal;
   Universite de Montreal; Columbia University; McGill University;
   Pennsylvania Commonwealth System of Higher Education (PCSHE); Temple
   University; Pennsylvania Commonwealth System of Higher Education
   (PCSHE); Temple University
RP Najjar, SM (corresponding author), Univ Toledo, Coll Med, 3000 Arlington Ave,Mail Stop 1009, Toledo, OH 43614 USA.
EM sonia.najjar@utoledo.edu
RI Ramakrishnan, Sadeesh/JSK-9511-2023; najjar, sonia/GXW-2217-2022
OI najjar, sonia/0000-0001-6209-8902; Scalia, Rosario/0000-0002-1829-943X
FU National Institutes of Health [R01 DK-054254, R01 DK-083850, R01
   HL-112248, P01 HL-36573, R01 HL-111877, R01 HL-45095, R01 DK-064344];
   American Heart Association-Great Rivers Affiliate [075100B]; US
   Department of Agriculture [USDA 38903-19826]; Canadian Institutes of
   Health Research [CIHR MOP-86582]; Deutsche Forschungsgemeinschaft [DFG
   ER 276 4-4, DFG TI 690 2-1 ER 276 7-1]; National Institute of Diabetes
   and Digestive and Kidney Diseases [P30DK020572] Funding Source: NIH
   RePORTER
FX This work was supported by grants from the National Institutes of
   Health: R01 DK-054254, R01 DK-083850, and R01 HL-112248 (S. M. Najjar),
   P01 HL-36573 (S. V. Pierre and S. M. Najjar), R01 HL-111877 (G.
   Vazquez), R01 HL-45095 (I. J. Goldberg), and R01 DK-064344 (R. Scalia);
   American Heart Association-Great Rivers Affiliate (075100B, G.
   Heinrich); US Department of Agriculture (USDA 38903-19826, S. M.
   Najjar); Canadian Institutes of Health Research (CIHR MOP-86582, N.
   Beauchemin), and Deutsche Forschungsgemeinschaft (DFG ER 276 4-4 and DFG
   TI 690 2-1 ER 276 7-1) (S. Ergun).
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NR 42
TC 32
Z9 36
U1 0
U2 14
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0193-1849
EI 1522-1555
J9 AM J PHYSIOL-ENDOC M
JI Am. J. Physiol.-Endocrinol. Metab.
PD AUG
PY 2013
VL 305
IS 4
BP E519
EP E529
DI 10.1152/ajpendo.00266.2013
PG 11
WC Endocrinology & Metabolism; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Physiology
GA 205GT
UT WOS:000323432000006
PM 23800882
OA Green Published
DA 2025-06-11
ER

PT J
AU Sartori-Valinotti, JC
   Venegas-Pont, MR
   LaMarca, BB
   Romero, DG
   Yanes, LL
   Racusen, LC
   Jones, AV
   Ryan, MJ
   Reckelhoff, JF
AF Sartori-Valinotti, Julio C.
   Venegas-Pont, Marcia R.
   LaMarca, Babbette B.
   Romero, Damian G.
   Yanes, Licy L.
   Racusen, Lorraine C.
   Jones, Allison V.
   Ryan, Michael J.
   Reckelhoff, Jane F.
TI Rosiglitazone reduces blood pressure in female Dahl salt-sensitive rats
SO STEROIDS
LA English
DT Article; Proceedings Paper
CT APS Conference on Sex Steroids and Gender in Cardiovascular-Renal
   Physiology and Pathophysiology
CY JUL 15-18, 2009
CL Broomfield, CO
SP Amer Physiol Soc
DE Ovariectomy; Menopause; Hypertension; Inflammation; Oxidative stress
ID PROLIFERATOR-ACTIVATED RECEPTORS; METABOLIC SYNDROME; ANGIOTENSIN-II;
   SEX-DIFFERENCES; HYPERTENSION; ALPHA; ESTROGEN; DISEASE
AB Postmenopausal women (PMW) are at greater risk for salt-sensitive hypertension and insulin resistance than premenopausal women. Peroxisome-proliferator-activated receptor-gamma (PPAR gamma) agonists reduce blood pressure (BP) and insulin resistance in humans. As in PMW, ovariectomy (OVX) increases salt sensitivity of BP and body weight in Dahl salt-sensitive (DS) rats. This study addressed whether rosiglitazone (ROSI), a PPAR gamma agonist, attenuates salt-sensitive hypertension in intact (INT) and OVX DS rats, and if so, whether insulin resistance, nitric oxide (NO), oxidative stress, and/or renal inflammation were contributing mediators. Telemetric BP was similar in OVX and INT on low salt diet (0.3% NaCl), but was higher in OVX than INT on high salt (8% NaCl). ROSI reduced BP in OVX and INT on both low and high salt diet, but only attenuated salt sensitivity of BP in OVX. Nitrate/nitrite excretion (NOx; index of NO) was similar in INT and OVX on low salt diet, and ROSI increased NO in both groups. High salt diet increased NOx in all groups but ROSI only increased NOx in OVX rats. OVX females exhibited insulin resistance, increases in body weight, plasma leptin, cholesterol, numbers of renal cortical macrophages, and renal MCP-1 and osteopontin mRNA expression compared to INT. ROSI reduced cholesterol and macrophage infiltration in OVX, but not INT. In summary, PPAR gamma activation reduces BP in INT and OVX females, but attenuates the salt sensitivity of BP in OVX only, likely due to increases in NO and in part to reductions in renal resident macrophages and inflammation. (C) 2009 Elsevier Inc. All rights reserved.
C1 [Reckelhoff, Jane F.] Univ Mississippi, Med Ctr, Dept Physiol & Biophys, Jackson, MS 39216 USA.
   [Romero, Damian G.] Univ Mississippi, Med Ctr, Dept Biochem, Jackson, MS 39216 USA.
   [Sartori-Valinotti, Julio C.; Venegas-Pont, Marcia R.; LaMarca, Babbette B.; Romero, Damian G.; Yanes, Licy L.; Jones, Allison V.; Ryan, Michael J.; Reckelhoff, Jane F.] Univ Mississippi, Med Ctr, Ctr Excellence Cardiovasc Renal Res, Jackson, MS 39216 USA.
   [Racusen, Lorraine C.] Johns Hopkins Sch Med, Baltimore, MD USA.
C3 University of Mississippi Medical Center; University of Mississippi;
   University of Mississippi Medical Center; University of Mississippi;
   University of Mississippi; University of Mississippi Medical Center;
   Johns Hopkins University; Johns Hopkins Medicine
RP Reckelhoff, JF (corresponding author), Univ Mississippi, Med Ctr, Dept Physiol & Biophys, 2500N State St, Jackson, MS 39216 USA.
EM jreckelhoff@physiology.umsmed.edu
FU NHLBI NIH HHS [R01 HL085907, K02 HL092284, P01 HL051971, HL085907, R01
   HL069194, HL51971, HL69194, R01 HL066072, HL66072] Funding Source:
   Medline
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NR 28
TC 20
Z9 23
U1 0
U2 3
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0039-128X
EI 1878-5867
J9 STEROIDS
JI Steroids
PD NOV
PY 2010
VL 75
IS 11
SI SI
BP 794
EP 799
DI 10.1016/j.steroids.2009.10.010
PG 6
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 651MS
UT WOS:000281932400009
PM 19883672
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Suzaki, Y
   Ozawa, Y
   Kobori, H
AF Suzaki, Yuki
   Ozawa, Yuri
   Kobori, Hiroyuki
TI Intrarenal oxidative stress and augmented angiotensinogen are precedent
   to renal injury in Zucker diabetic fatty rats
SO INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
LA English
DT Article
DE renin-angiotensin system; diabetes mellitus; angiotensinogen; oxidative
   stress; renal injury
ID CONVERTING-ENZYME-INHIBITION; PLATELET ACTIVATION; EXPRESSION;
   NEPHROPATHY; BLOCKADE; MELLITUS; SYSTEM; MODEL; RECEPTORS; PROTEIN
AB The Zucker diabetic fatty ( ZDF) rat is a model of type II diabetes and metabolic syndrome based on impaired glucose tolerance caused by the inherited insulin-resistance gene. The ZDF rat exhibits progressive nephropathy; however, the detailed mechanisms have remained unclear. This study was performed to examine the possible involvement of enhanced intrarenal angiotensinogen in the development of renal injury in ZDF rats. Genetic pairs of male ZDF rats and control lean rats ( N= 6 each) were maintained from 12 to 17 weeks of age. At 17 weeks of age, fasting blood glucose and urinary 8- isoprostane levels were significantly higher in ZDF rats compared with the controls. Systolic blood pressure progressively increased in ZDF rats from 120+/- 1 to 137+/- 1 mmHg during this period. In contrast, systolic blood pressure did not increase in the controls. Kidney angiotensinogen protein levels were significantly increased in ZDF rats compared with the controls ( 1.83+/- 0.34 vs. 1.00+/- 0.17, relative ratio). Expression of angiotensin II type 1a receptor mRNA was similar between these groups. The measured indices of renal damage in the present study ( glomerular sclerosis, interstitial expansion, glomerular macrophage infiltration, and renal arterial proliferation) were not significantly increased at this stage in ZDF rats. However, we previously showed that the increased reactive oxygen species- related angiotensinogen enhancement plays an important role in the development of renal injury in a genetic salt- sensitive hypertension. Thus, the present data suggest that elevated reactive oxygen species and reactive oxygen species- associated augmentation of intrarenal angiotensinogen may initiate the development of renal injury in ZDF rats.
C1 Tulane Univ, Hlth Sci Ctr, Hypertens & Renal Ctr Excellence, New Orleans, LA 70112 USA.
   Tulane Univ, Hlth Sci Ctr, Dept Physiol, New Orleans, LA 70112 USA.
C3 Tulane University; Tulane University
RP Kobori, H (corresponding author), Tulane Univ, Hlth Sci Ctr, Hypertens & Renal Ctr Excellence, 1430 Tulane Ave,SL39, New Orleans, LA 70112 USA.
EM hkobori@tulane.edu
RI ; Kobori, Hiroyuki/F-1994-2014
OI Suzaki, Yuki/0000-0001-8883-0823; Kobori, Hiroyuki/0000-0001-5128-5059
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NR 43
TC 46
Z9 50
U1 0
U2 1
PU IVYSPRING INT PUBL
PI LAKE HAVEN
PA PO BOX 4546, LAKE HAVEN, NSW 2263, AUSTRALIA
SN 1449-2288
J9 INT J BIOL SCI
JI Int. J. Biol. Sci.
PY 2007
VL 3
IS 1
BP 40
EP 46
PG 7
WC Biochemistry & Molecular Biology; Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics
GA 174DL
UT WOS:000246921300006
PM 17200690
DA 2025-06-11
ER

PT J
AU Adetunji, JA
   Fasae, KD
   Awe, AI
   Paimo, OK
   Adegoke, AM
   Akintunde, JK
   Sekhoacha, MP
AF Adetunji, Joy A.
   Fasae, Kehinde D.
   Awe, Ayobami I.
   Paimo, Oluwatomiwa K.
   Adegoke, Ayodeji M.
   Akintunde, Jacob K.
   Sekhoacha, Mamello P.
TI The protective roles of citrus flavonoids, naringenin, and naringin on
   endothelial cell dysfunction in diseases
SO HELIYON
LA English
DT Review
DE Endothelial dysfunction; Naringin; Naringenin; Citrus flavonoids;
   Microvasculature; Therapeutics
ID NF-KAPPA-B; OXIDATIVE STRESS; DEPENDENT VASODILATION; VASCULAR
   DYSFUNCTION; INSULIN-RESISTANCE; REPERFUSION INJURY; METABOLIC SYNDROME;
   RECEPTOR-ALPHA; INNATE CONTROL; GROWTH-FACTOR
AB The endothelial cells (ECs) make up the inner lining of blood vessels, acting as a barrier separating the blood and the tissues in several organs. ECs maintain endothelium integrity by controlling the constriction and relaxation of the vasculature, blood fluidity, adhesion, and migration. These actions of ECs are efficiently coordinated via an intricate signaling network connecting receptors, and a wide range of cellular macromolecules. ECs are naturally quiescent i. e.; they are not stimulated and do not proliferate. Upon infection or disease, ECs become activated, and this alteration is pivotal in the pathogenesis of a spectrum of human neurological, cardiovascular, diabetic, cancerous, and viral diseases. Considering the central position that ECs play in disease pathogenesis, therapeutic options have been targeted at improving ECs integrity, assembly, functioning, and health. The dietary intake of flavonoids present in citrus fruits has been associated with a reduced risk of endothelium dysfunction. Naringenin (NGN) and Naringin (NAR), major flavonoids in grapefruit, tomatoes, and oranges possess anti-inflammatory, antioxidant properties, and cell survival potentials, which improve the health of the vascular endothelium. In this review, we provide a comprehensive summary and present the advances in understanding of the mechanisms through which NGN and NAR modulate the biomarkers of vascular dysfunction and protect the endothelium against unresolved inflammation, oxidative stress, atherosclerosis, and angiogenesis. We also provide perspectives and suggest further studies that will help assess the efficacy of citrus flavonoids in the therapeutics of human vascular diseases.
C1 [Adetunji, Joy A.] Univ Ibadan, Coll Med, Dept Biochem, Nutr & Ind Biochem Unit, Ibadan, Nigeria.
   [Fasae, Kehinde D.] Univ Tennessee, Dept Biomed & Diagnost Sci, Knoxville, TN USA.
   [Awe, Ayobami I.] Catholic Univ Amer, Dept Biol, Washington, DC USA.
   [Paimo, Oluwatomiwa K.; Akintunde, Jacob K.] Fed Univ Agr, Coll Biosci, Dept Biochem, Abeokuta, Nigeria.
   [Adegoke, Ayodeji M.; Sekhoacha, Mamello P.] Univ Free State, Dept Pharmacol, POB 339, ZA-9300 Bloemfontein, South Africa.
   [Adegoke, Ayodeji M.] Univ Ibadan, Coll Med, Dept Biochem, Canc Res & Mol Biol Labs, Ibadan 200005, Nigeria.
C3 University of Ibadan; University of Tennessee System; University of
   Tennessee Knoxville; UT Institute of Agriculture; Catholic University of
   America; University of Agriculture, Abeokuta; University of the Free
   State; University of Ibadan
RP Adegoke, AM (corresponding author), Univ Free State, Dept Pharmacol, POB 339, ZA-9300 Bloemfontein, South Africa.
EM Adegoke.AM@ufs.ac.za
RI Awe, Ayobami/ECZ-8369-2022; Adegoke, Ayodeji/JPY-2660-2023; Fasae,
   Kehinde/AAA-9202-2021
OI Adetunji, Joy/0000-0001-9312-9919; AWE, AYOBAMI/0000-0002-1469-538X;
   Adegoke, Ayodeji/0000-0002-9968-8014
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NR 240
TC 23
Z9 23
U1 1
U2 5
PU CELL PRESS
PI CAMBRIDGE
PA 50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA
EI 2405-8440
J9 HELIYON
JI Heliyon
PD JUN
PY 2023
VL 9
IS 6
AR e17166
DI 10.1016/j.heliyon.2023.e17166
EA JUN 2023
PG 21
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA O2RB0
UT WOS:001042331900001
PM 37484296
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Kura, B
   Szantova, M
   LeBaron, TW
   Mojto, V
   Barancik, M
   Bacova, BS
   Kalocayova, B
   Sykora, M
   Okruhlicova, L
   Tribulova, N
   Gvozdjakova, A
   Sumbalova, Z
   Kucharska, J
   Faktorova, X
   Jakabovicova, M
   Durkovicová, Z
   Macutek, J
   Koscová, M
   Slezak, J
AF Kura, Branislav
   Szantova, Maria
   LeBaron, Tyler W.
   Mojto, Viliam
   Barancik, Miroslav
   Bacova, Barbara Szeiffova
   Kalocayova, Barbora
   Sykora, Matus
   Okruhlicova, Ludmila
   Tribulova, Narcisa
   Gvozdjakova, Anna
   Sumbalova, Zuzana
   Kucharska, Jarmila
   Faktorova, Xenia
   Jakabovicova, Martina
   Durkovicova, Zuzana
   Macutek, Jan
   Koscova, Michaela
   Slezak, Jan
TI Biological Effects of Hydrogen Water on Subjects with NAFLD: A
   Randomized, Placebo-Controlled Trial
SO ANTIOXIDANTS
LA English
DT Article
DE inflammation; matrix metalloproteinases; molecular hydrogen; NAFLD;
   oxidative stress; ROS
ID FATTY LIVER-DISEASE; RICH WATER; MOLECULAR-HYDROGEN; METABOLIC SYNDROME;
   OXIDATIVE DAMAGE; ORAL INTAKE; CHOLESTEROL; MORTALITY; PROTEIN; DNA
AB Non-alcoholic fatty liver disease (NAFLD) is a liver pathology affecting around 25% of the population worldwide. Excess oxidative stress, inflammation and aberrant cellular signaling can lead to this hepatic dysfunction and eventual carcinoma. Molecular hydrogen has been recognized for its selective antioxidant properties and ability to attenuate inflammation and regulate cellular function. We administered hydrogen-rich water (HRW) to 30 subjects with NAFLD in a randomized, double-blinded, placebo-controlled manner for eight weeks. Phenotypically, we observed beneficial trends (p > 0.05) in decreased weight (approximate to 1 kg) and body mass index in the HRW group. HRW was well-tolerated, with no significant changes in liver enzymes and a trend of improved lipid profile and reduced lactate dehydrogenase levels. HRW tended to non-significantly decrease levels of nuclear factor kappa B, heat shock protein 70 and matrix metalloproteinase-9. Interestingly, there was a mild, albeit non-significant, tendency of increased levels of 8-hydroxy-2'-deoxyguanosine and malondialdehyde in the HRW group. This mild increase may be indicative of the hormetic effects of molecular hydrogen that occurred prior to the significant clinical improvements reported in previous longer-term studies. The favorable trends in this study in conjunction with previous animal and clinical findings suggest that HRW may serve as an important adjuvant therapy for promoting and maintaining optimal health and wellness. Longer term studies focused on prevention, maintenance, or treatment of NAFLD and early stages of NASH are warranted.
C1 [Kura, Branislav; LeBaron, Tyler W.; Barancik, Miroslav; Bacova, Barbara Szeiffova; Kalocayova, Barbora; Sykora, Matus; Okruhlicova, Ludmila; Tribulova, Narcisa; Slezak, Jan] Slovak Acad Sci, Ctr Expt Med, Inst Heart Res, Bratislava 84104, Slovakia.
   [Szantova, Maria; Mojto, Viliam; Jakabovicova, Martina; Durkovicova, Zuzana] Comenius Univ, Fac Med, Dept Internal Med 3, Bratislava 81372, Slovakia.
   [LeBaron, Tyler W.] Mol Hydrogen Inst, Enoch, UT 84721 USA.
   [LeBaron, Tyler W.] Southern Utah Univ, Dept Kinesiol & Outdoor Recreat, Cedar City, UT 84721 USA.
   [Gvozdjakova, Anna; Sumbalova, Zuzana; Kucharska, Jarmila] Comenius Univ, Med Fac, Pharmacobiochem Lab, Med Dept 3, Bratislava 81108, Slovakia.
   [Faktorova, Xenia] Slovak Med Univ, Internal Clin, Hosp St Michael, Bratislava 81108, Slovakia.
   [Macutek, Jan; Koscova, Michaela] Slovak Acad Sci, Math Inst, Bratislava 81473, Slovakia.
   [Macutek, Jan] Constantine Philosopher Univ Nitra, Fac Nat Sci, Dept Math, Nitra 94901, Slovakia.
C3 Slovak Academy of Sciences; Institute for Heart Research, SAS; Centre of
   Experimental Medicine, SAS; Comenius University Bratislava; Utah System
   of Higher Education; Southern Utah University; Comenius University
   Bratislava; Slovak Medical University Bratislava; Slovak Academy of
   Sciences; Mathematical Institute, SAS; Constantine the Philosopher
   University in Nitra
RP Slezak, J (corresponding author), Slovak Acad Sci, Ctr Expt Med, Inst Heart Res, Bratislava 84104, Slovakia.
EM jan.slezak@savba.sk
RI Sykora, Matus/AAV-3647-2020; LeBaron, Tyler/GLT-7071-2022; Mačutek,
   Ján/AAH-9490-2020; Koščová, Michaela/AET-5587-2022; Szeiffova Bacova,
   Barbara/ABH-2723-2021; Koscova, Michaela/MFI-6897-2025
OI Koscova, Michaela/0000-0002-5541-1224; Gvozdjakova,
   Anna/0000-0002-5139-9213; LeBaron, Tyler/0000-0001-9164-6728; Sykora,
   Matus/0000-0002-0438-3956; Macutek, Jan/0000-0003-1712-4395; Kura,
   Branislav/0000-0001-6743-491X; Kalocayova, Barbora/0000-0002-5283-7561;
   Sumbalova, Zuzana/0000-0001-9454-6255
FU Slovak Research and Development Agency [(APVV)0241-11, APVV-15-0376,
   APVV-19-0317, ITMS 26230120009, APVV-190317]; Scientific grant agency of
   the Ministry of Education of the Slovak Republic (VEGA) [2/0063/18,
   2/0092/222, 2/0148/22]; HRW Natural Health Products Inc.; Ministry of
   Education of the Slovak Republic [VEGA 2/0092/22]; ministry of Health of
   Slovak Republic [2019/4-CEMSAV-1]
FX This research was funded by the Slovak Research and Development Agency
   (APVV)0241-11, APVV-15-0376, APVV-19-0317; ITMS 26230120009; Scientific
   grant agency of the Ministry of Education of the Slovak Republic (VEGA)
   2/0063/18, 2/0092/222, 2/0148/22, and by HRW Natural Health Products
   Inc. The funders had no role in randomization, data collection,
   interpretation, manuscript writing, or the decision to publish. Slovak
   Research and Development Agency: APVV-190317. Scientific grant agency of
   the Ministry of Education of the Slovak Republic: VEGA 2/0092/22. Grant
   of ministry of Health of Slovak Republic: 2019/4-CEMSAV-1.
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NR 44
TC 22
Z9 22
U1 3
U2 14
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD OCT
PY 2022
VL 11
IS 10
AR 1935
DI 10.3390/antiox11101935
PG 12
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA 5N9EI
UT WOS:000872088900001
PM 36290657
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Lan, T
   Yu, Y
   Zhang, J
   Li, HN
   Weng, QQ
   Jiang, S
   Tian, S
   Xu, TH
   Hu, S
   Yang, GZ
   Zhang, Y
   Wang, WX
   Wang, LX
   Zhu, Q
   Rong, XL
   Guo, J
AF Lan, Tian
   Yu, Yang
   Zhang, Jing
   Li, Haonan
   Weng, Qiqing
   Jiang, Shuo
   Tian, Song
   Xu, Tonghao
   Hu, Sha
   Yang, Guizhi
   Zhang, Yan
   Wang, Weixuan
   Wang, Lexun
   Zhu, Qing
   Rong, Xianglu
   Guo, Jiao
TI Cordycepin Ameliorates Nonalcoholic Steatohepatitis by Activation of the
   AMP-Activated Protein Kinase Signaling Pathway
SO HEPATOLOGY
LA English
DT Article
ID REDUCES FEATURES; ADIPOSE-TISSUE; LIVER; ADENOSINE; NASH; EPIDEMIOLOGY;
   INFLAMMATION; INHIBITION; RESPONSES; MILITARIS
AB BACKGROUND AND AIMS: Nonalcoholic fatty liver disease, especially nonalcoholic steatohepatitis (NASH), has become a major cause of liver transplantation and liver-associated death. NASH is the hepatic manifestation of metabolic syndrome and is characterized by hepatic steatosis, inflammation, hepatocellular injury, and different degrees of fibrosis. However, there is no US Food and Drug Administration-approved medication to treat this devastating disease. Therapeutic activators of the AMP-activated protein kinase (AMPK) have been proposed as a potential treatment for metabolic diseases such as NASH. Cordycepin, a natural product isolated from the traditional Chinese medicine Cordyceps militaris, has recently emerged as a promising drug candidate for metabolic diseases.
   APPROACH AND RESULTS: We evaluated the effects of cordycepin on lipid storage in hepatocytes, inflammation, and fibrosis development in mice with NASH. Cordycepin attenuated lipid accumulation, inflammation, and lipotoxicity in hepatocytes subjected to metabolic stress. In addition, cordycepin treatment significantly and dose-dependently decreased the elevated levels of serum aminotransferases in mice with diet-induced NASH. Furthermore, cordycepin treatment significantly reduced hepatic triglyceride accumulation, inflammatory cell infiltration, and hepatic fibrosis in mice. In vitro and in vivo mechanistic studies revealed that a key mechanism linking the protective effects of cordycepin were AMPK phosphorylation-dependent, as indicated by the finding that treatment with the AMPK inhibitor Compound C abrogated cordycepin-induced hepatoprotection in hepatocytes and mice with NASH.
   CONCLUSION: Cordycepin exerts significant protective effects against hepatic steatosis, inflammation, liver injury, and fibrosis in mice under metabolic stress through activation of the AMPK signaling pathway. Cordycepin might be an AMPK activator that can be used for the treatment of NASH.
C1 [Lan, Tian; Yu, Yang; Zhang, Jing; Li, Haonan; Weng, Qiqing; Jiang, Shuo; Xu, Tonghao; Yang, Guizhi; Wang, Weixuan; Wang, Lexun; Zhu, Qing; Rong, Xianglu; Guo, Jiao] Guangdong Pharmaceut Univ, Guangdong Metab Dis Res Ctr Integrated Chinese &, Guangzhou, Peoples R China.
   [Lan, Tian; Yu, Yang; Zhang, Jing; Li, Haonan; Weng, Qiqing; Jiang, Shuo; Xu, Tonghao; Yang, Guizhi; Wang, Weixuan; Wang, Lexun; Zhu, Qing; Rong, Xianglu; Guo, Jiao] Guangdong Pharmaceut Univ, Inst Chinese Med, Guangzhou, Peoples R China.
   [Lan, Tian; Yu, Yang; Zhang, Jing; Li, Haonan; Weng, Qiqing; Jiang, Shuo; Xu, Tonghao; Yang, Guizhi; Wang, Weixuan; Wang, Lexun; Zhu, Qing; Rong, Xianglu; Guo, Jiao] Minist Educ China, Key Lab Glucolipid Metab Disorder, Guangzhou, Peoples R China.
   [Lan, Tian; Yu, Yang; Zhang, Jing; Li, Haonan; Weng, Qiqing; Jiang, Shuo; Xu, Tonghao; Yang, Guizhi; Wang, Weixuan; Wang, Lexun; Zhu, Qing; Rong, Xianglu; Guo, Jiao] Guangdong Pharmaceut Univ, Guangdong TCM Key Lab Metab Dis, Guangzhou, Peoples R China.
   [Tian, Song; Hu, Sha; Zhang, Yan] Wuhan Univ, Renmin Hosp, Dept Cardiol, Wuhan, Peoples R China.
C3 Guangdong Pharmaceutical University; Guangdong Pharmaceutical
   University; Ministry of Education - China; Guangdong Pharmaceutical
   University; Wuhan University
RP Guo, J (corresponding author), Guangdong Pharmaceut Univ, Guangzhou Higher Educ Mega Ctr, 280 Wai Huan Dong Rd, Guangzhou 510006, Peoples R China.
EM gyguoyz@163.com
RI Li, Haonan/IQV-4567-2023; weng, qi/KHC-8473-2024; Tian,
   Song/HJI-2076-2023
FU National Key R&D Plan of China's "Research on Modernization of
   Traditional Chinese Medicine" program [2018YFC1704200]; National Natural
   Science Foundation of China [81530102, 81830113, 81870420, 82070590];
   Major Basic and Applied Basic Research Projects in Guangdong Province of
   China [2019B030302005]
FX Supported by grants from the National Key R&D Plan of China's "Research
   on Modernization of Traditional Chinese Medicine" program
   (2018YFC1704200), the National Natural Science Foundation of China
   (81530102, 81830113, 81870420, and 82070590), and the Major Basic and
   Applied Basic Research Projects in Guangdong Province of China
   (2019B030302005).
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NR 51
TC 112
Z9 125
U1 13
U2 139
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0270-9139
EI 1527-3350
J9 HEPATOLOGY
JI Hepatology
PD AUG
PY 2021
VL 74
IS 2
BP 686
EP 703
DI 10.1002/hep.31749
PG 18
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA UF3RR
UT WOS:000688494200012
PM 33576035
OA Green Published
DA 2025-06-11
ER

PT J
AU Mengesha, T
   Sekaran, NG
   Mehare, T
AF Mengesha, Tewodros
   Sekaran, N. Gnana
   Mehare, Tsegaye
TI Hepatoprotective effect of silymarin on fructose induced nonalcoholic
   fatty liver disease in male albino wistar rats
SO BMC COMPLEMENTARY MEDICINE AND THERAPIES
LA English
DT Article
DE Nonalcoholic fatty liver disease; Silymarin; Lipid peroxidation;
   Dyslipidemia; Total antioxidant status; Reduced glutathione
AB Background Nonalcoholic fatty liver disease (NAFLD) is one of the most common causes of chronic liver disease in the Western world, and it's likely to parallel the increasing prevalence of type 2 diabetes, obesity, and other components of metabolic syndrome. However, optimal treatment for NAFLD has not been established yet. Therefore, this study investigated the hepatoprotective effect of silymarin on fructose-induced nonalcoholic fatty liver disease in rats. Methods Thirty male Wistar rats were randomly divided into five groups; normal control group that consumed tap water, silymarin control group that consumed tap water and silymarin (400 mg/kg/day), fructose control group that consumed 20% fructose solution, treatment group that consumed 20% fructose solution and silymarin (200 mg/kg/day), and another treatment group that consumed 20% fructose solution and silymarin (400 mg/kg/day). Hepatic triglyceride, serum lipid profile, lipid peroxidation, antioxidant level, morphological features, and histopathological changes were investigated. The data were analyzed using one-way analysis of variance (ANOVA) followed by Tukey multiple comparison test. Statistical significance was determined at p < 0.05. Results This study showed that the fructose control group had a significantly high value in the stage of steatosis grade, hepatic triglyceride, serum triglyceride, total cholesterol, low-density lipoprotein cholesterol, alanine aminotransferase, aspartate aminotransferase, and hepatic malondialdehyde concentration as compared to the normal control. However, significantly low values of reduced glutathione and plasma total antioxidant capacity were found. The altered parameters due to fructose drastic effect were ameliorated by silymarin treatment. Conclusions The fructose control group developed dyslipidemia, oxidative stress, and mild steatosis that are the characteristics features of NAFLD. However, silymarin-treated groups showed amelioration in oxidative stress, dyslipidemia, and steatosis.
C1 [Mengesha, Tewodros; Mehare, Tsegaye] Dilla Univ, Dept Biomed Sci, Coll Med & Hlth Sci, Dilla, Ethiopia.
   [Sekaran, N. Gnana] Addis Ababa Univ, Sch Med, Dept Biochem, Addis Ababa, Ethiopia.
C3 Dilla University; Addis Ababa University
RP Mengesha, T (corresponding author), Dilla Univ, Dept Biomed Sci, Coll Med & Hlth Sci, Dilla, Ethiopia.
EM mengesha.teda@gmail.com
FU Addis Ababa University College of health and medical science, Department
   of Biochemistry, School of Pharmaceutical Sciences; Addis Ababa
   University College of health and medical science, Department of
   Microbiology and immunology lab facilities
FX We would like to acknowledge the support of Addis Ababa University
   College of health and medical science, Department of Biochemistry,
   School of Pharmaceutical Sciences, and Department of Microbiology and
   immunology lab facilities. We also acknowledge the support of
   biochemistry, animal house, and Pharmaceutical Sciences staff for their
   assistance during the studies.
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NR 64
TC 29
Z9 30
U1 6
U2 15
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 2662-7671
J9 BMC COMPLEMENT MED
JI BMC Complement. Med. Ther.
PD MAR 30
PY 2021
VL 21
IS 1
AR 104
DI 10.1186/s12906-021-03275-5
PG 13
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA RH5BK
UT WOS:000636233700001
PM 33785007
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU de Carvalho, APA
   Conte-Junior, CA
AF Azevedo de Carvalho, Anna Paula
   Conte-Junior, Carlos Adam
TI Health benefits of phytochemicals from Brazilian native foods and
   plants: Antioxidant, antimicrobial, anti-cancer, and risk factors of
   metabolic/endocrine disorders control
SO TRENDS IN FOOD SCIENCE & TECHNOLOGY
LA English
DT Article
DE Bioactive compounds; Herbal medicine; Brazilian fruits; Obesity; Cancer;
   Antiviral
ID IN-VITRO; CHEMICAL-COMPOSITION; INHIBITORY-ACTIVITY; PHENOLIC-COMPOUNDS;
   OXIDATIVE STRESS; ALPHA-AMYLASE; EXTRACTS; CANCER; ANTIBACTERIAL; FRUITS
AB Background: Brazil has over 40,000 varied plant species rich in phytochemicals, expressing 20% of the world?s flora. Due to its immense diversity, Brazil presents a high potential to produce knowledge and products with added value useful in phytomedicine and food supplements to prevent and treat several types of diseases as infectious/parasitic, cancer, diabetes, cardiovascular, and others endocrine/metabolic disorders. Scope and approach: This comprehensive review focuses on advances in knowledge and understanding of the bioactive compounds nature of primary and secondary metabolites of native foods in Brazil. It covers antioxidant, antimicrobial, antihelmintic, anti-cancer and targets risk factors of metabolic/endocrine disorders by edible and non-edible parts of fruit products intake. Key findings and conclusions: The Brazilian native flora rich in bioactive compounds exert high inhibition hates (in most cases, better than the reference antibiotics) and high selectivity index against several parasites, viruses, fungal and bacterias, without cytotoxicity. However, coronaviruses can get more attention. Moreover, several endemic species-rich in polyphenols and terpenoids demonstrated cancer cell selectivity, no cytotoxicity to healthy cells, and the balance between prooxidant and antioxidant levels that define genomic integrity by cell redox status modulation, thus controlling the cancer cells proliferation. Furthermore, oxidative stress and other metabolic syndrome risk factors can also be avoided by Brazilian flora. The Cerrado and Pampa fruits received significant attention targeting cancer and cardiometabolic/endocrine disorders, while little-explored fruits of Caatinga, Amazon, Pantanal and Atlantic forest, rich sources of antioxidants phenolics, flavonoids, polysaccharides, vitamin C, and terpenes, can still generate exciting discoveries, including food packaging solutions.
C1 [Azevedo de Carvalho, Anna Paula; Conte-Junior, Carlos Adam] Fed Univ Rio De Janeiro UFRJ, Inst Chem IQ, Dept Biochem, BR-21941909 Rio De Janeiro, RJ, Brazil.
   [Azevedo de Carvalho, Anna Paula; Conte-Junior, Carlos Adam] Fed Univ Rio De Janeiro UFRJ, Technol Dev Support Lab LADETEC, Ctr Food Anal NAL, BR-21941909 Rio De Janeiro, RJ, Brazil.
   [Azevedo de Carvalho, Anna Paula; Conte-Junior, Carlos Adam] Fed Univ Rio De Janeiro UFRJ, Dept Biochem, Lab Adv Anal Biochem & Mol Biol LAABBM, BR-21941909 Rio De Janeiro, RJ, Brazil.
   [Azevedo de Carvalho, Anna Paula; Conte-Junior, Carlos Adam] Fed Univ Rio De Janeiro UFRJ, Inst Chem IQ, Grad Program Food Sci PPGCAL, BR-21941909 Rio De Janeiro, RJ, Brazil.
   [Azevedo de Carvalho, Anna Paula; Conte-Junior, Carlos Adam] Fed Univ Rio De Janeiro UFRJ, Inst Chem IQ, Grad Program Chem PGQu, BR-21941909 Rio De Janeiro, RJ, Brazil.
   [Conte-Junior, Carlos Adam] Fluminense Fed Univ UFF, Fac Vet Med, Grad Program Vet Hyg PPGHV, BR-24230340 Niteroi, RJ, Brazil.
   [Conte-Junior, Carlos Adam] Oswaldo Cruz Fdn FIOCRUZ, Natl Inst Hlth Qual Control INCQS, Grad Program Sanit Surveillance PPGVS, BR-21040900 Rio De Janeiro, RJ, Brazil.
C3 Universidade Federal Fluminense; Fundacao Oswaldo Cruz
RP de Carvalho, APA; Conte-Junior, CA (corresponding author), Univ Fed Rio De Janeiro UFRJ, Inst Quim, Dept Bioquim, BR-21941901 Rio De Janeiro, RJ, Brazil.
EM anna_paulacarvalho@hotmail.com; conte@iq.ufrj.br
RI Azevedo De Carvalho, Anna Paula/GPP-3985-2022; Conte-Junior,
   Carlos/J-5815-2014
OI Azevedo De Carvalho, Anna Paula/0000-0001-9258-5947; Conte-Junior,
   Carlos/0000-0001-6133-5080
FU Fundacao Carlos Chagas Filho de Amparo a Pesquisa do Estado do Rio de
   Janeiro - Brasil (FAPERJ) [E-26/2543334/2019, E-26/010.000.984/2019,
   E-26/010.000148/2020, E-26/200.060/2020]; Conselho Nacional de
   Desenvolvimento Cientifico e Tecnologico - Brasil (CNPq) [311422/2016-0]
FX This work was supported by Fundacao Carlos Chagas Filho de Amparo a
   Pesquisa do Estado do Rio de Janeiro - Brasil (FAPERJ) [grant number
   E-26/2543334/2019, E-26/010.000.984/2019, E-26/010.000148/2020, and
   E-26/200.060/2020]; and the Conselho Nacional de Desenvolvimento
   Cientifico e Tecnologico - Brasil (CNPq) [grant number 311422/2016-0].
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NR 88
TC 67
Z9 69
U1 4
U2 27
PU ELSEVIER SCIENCE LONDON
PI LONDON
PA 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND
SN 0924-2244
EI 1879-3053
J9 TRENDS FOOD SCI TECH
JI Trends Food Sci. Technol.
PD MAY
PY 2021
VL 111
BP 534
EP 548
DI 10.1016/j.tifs.2021.03.006
EA MAR 2021
PG 15
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA RN9XE
UT WOS:000640705100005
DA 2025-06-11
ER

PT J
AU Fang, F
   Nuyt, AM
   Garofalo, C
   Zhang, J
   Julien, P
   Fraser, W
   Levy, E
   Luo, ZC
AF Fang, Fang
   Nuyt, Anne Monique
   Garofalo, Carole
   Zhang, Jun
   Julien, Pierre
   Fraser, William
   Levy, Emile
   Luo, Zhong-Cheng
TI Oxidized LDL, insulin sensitivity and beta-cell function in newborns
SO BMJ OPEN DIABETES RESEARCH & CARE
LA English
DT Article
ID LOW-DENSITY-LIPOPROTEIN; METABOLIC SYNDROME; OXIDATIVE STRESS;
   PREVALENCE; RESISTANCE; SECRETION
AB Introduction Oxidized low-density lipoprotein (OxLDL), a biomarker of oxidative stress, itself possesses proatherogenic and proinflammatory effects. Elevated circulating OxLDL levels have been consistently associated with insulin resistance and diabetes in adults. We sought to assess whether OxLDL may be associated with insulin sensitivity and beta-cell function in early life.
   Research design and methods In a birth cohort study, we assessed cord plasma OxLDL concentration and OxLDL to total LDL ratio in relation to glucose to insulin ratio (an indicator of fetal insulin sensitivity), proinsulin to insulin ratio (an indicator of fetal beta-cell function), and leptin and adiponectin concentrations in 248 singleton newborns.
   Results Cord plasma OxLDL concentration was positively correlated with glucose to insulin ratio (r=0.24, p<0.001) and proinsulin to insulin ratio (r=0.20, p<0.001) and was not correlated with leptin or adiponectin. Adjusting for maternal and neonatal characteristics, each log unit increase in cord plasma OxLDL concentration was associated with a 25.8% (95% CI 12.8% to 40.3%) increase in glucose to insulin ratio and a 19.0% (95% CI 6.8% to 32.9%) increase in proinsulin to insulin ratio, respectively. Similar associations were observed for cord plasma OxLDL to LDL ratio in relation to cord plasma glucose to insulin ratio and proinsulin to insulin ratio.
   Conclusions Higher OxLDL levels were associated with lower fetal beta-cell function (higher proinsulin to insulin ratio) but higher insulin sensitivity (higher glucose to insulin ratio). The study is the first to demonstrate that OxLDL may affect glucose metabolic health in early life in humans.
C1 [Fang, Fang; Zhang, Jun; Luo, Zhong-Cheng] Shanghai Jiao Tong Univ, Xinhua Hosp, Sch Med, Dept Pediat,Minist Educ,Shanghai Key Lab Children, Shanghai, Peoples R China.
   [Fang, Fang; Luo, Zhong-Cheng] Univ Toronto, Mt Sinai Hosp, Prosserman Ctr Populat Hlth Res, Dept Obstet & Gynecol,Lunenfeld Tanenbaum Res Ins, Toronto, ON, Canada.
   [Nuyt, Anne Monique; Garofalo, Carole; Fraser, William; Levy, Emile] Univ Montreal, St Justine Univ Hosp & Res Ctr, Montreal, PQ, Canada.
   [Julien, Pierre] Laval Univ, CHU Quebec, Res Ctr, Dept Med Mol & Oncol Endocrinol, Quebec City, PQ, Canada.
   [Julien, Pierre] Laval Univ, CHU Quebec, Res Ctr, Human Genom Res Ctr, Quebec City, PQ, Canada.
   [Fraser, William] Univ Sherbrooke, Dept Obstet & Gynecol, Sherbrooke, PQ, Canada.
C3 Shanghai Jiao Tong University; Ministry of Education - China; University
   of Toronto; Sinai Health System Toronto; Lunenfeld Tanenbaum Research
   Institute; Universite de Montreal; Laval University; Laval University
   Hospital; Laval University; Laval University Hospital; University of
   Sherbrooke
RP Luo, ZC (corresponding author), Shanghai Jiao Tong Univ, Xinhua Hosp, Sch Med, Dept Pediat,Minist Educ,Shanghai Key Lab Children, Shanghai, Peoples R China.; Luo, ZC (corresponding author), Univ Toronto, Mt Sinai Hosp, Prosserman Ctr Populat Hlth Res, Dept Obstet & Gynecol,Lunenfeld Tanenbaum Res Ins, Toronto, ON, Canada.
EM zcluo@lunenfeld.ca
RI Julien, Pierre/AGO-7542-2022; Zhang, Jun/U-2902-2018; Liang,
   Yongfeng/D-1459-2013; LUO, Zhong-Cheng/T-3882-2017
OI Zhang, Jun/0000-0003-1706-1611; LUO, Zhong-Cheng/0000-0002-1794-1312
FU Ministry of Science and Technology of China National Key Research
   Program [2019YFA0802501]; Canadian Institutes of Health Research (CIHR)
   [158616, 79896]; National Natural Science Foundation of China [81903323]
FX This work was supported by research grants from the Ministry of Science
   and Technology of China National Key Research Program (2019YFA0802501),
   the Canadian Institutes of Health Research (CIHR grant #158616 and
   #79896) and the National Natural Science Foundation of China (81903323).
   The funders had not been involved in study design, data collection and
   analysis, manuscript preparation and publication decisions.
CR Aguilar M, 2015, JAMA-J AM MED ASSOC, V313, P1973, DOI 10.1001/jama.2015.4260
   American Diabetes Association, 2003, Diabetes Care, V26 Suppl 1, pS103
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NR 30
TC 2
Z9 2
U1 0
U2 3
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
EI 2052-4897
J9 BMJ OPEN DIAB RES CA
JI BMJ Open Diab. Res. Care
PY 2021
VL 9
IS 1
AR e001435
DI 10.1136/bmjdrc-2020-001435
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA QU7WY
UT WOS:000627490600001
PM 33687921
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Drescher, HK
   Schippers, A
   Rosenhain, S
   Gremse, F
   Bongiovanni, L
   de Bruin, A
   Eswaran, S
   Gallage, SU
   Pfister, D
   Szydlowska, M
   Heikenwalder, M
   Weiskirchen, S
   Wagner, N
   Trautwein, C
   Weiskirchen, R
   Kroy, DC
AF Drescher, Hannah K.
   Schippers, Angela
   Rosenhain, Stefanie
   Gremse, Felix
   Bongiovanni, Laura
   de Bruin, Alain
   Eswaran, Sreepradha
   Gallage, Suchira U.
   Pfister, Dominik
   Szydlowska, Marta
   Heikenwalder, Mathias
   Weiskirchen, Sabine
   Wagner, Norbert
   Trautwein, Christian
   Weiskirchen, Ralf
   Kroy, Daniela C.
TI L-Selectin/CD62L Is a Key Driver of Non-Alcoholic Steatohepatitis in
   Mice and Men
SO CELLS
LA English
DT Article
DE non-alcoholic steatohepatitis; NASH; CD62L; L-Selectin; insulin
   resistance
ID SYSTEMIC-LUPUS-ERYTHEMATOSUS; FATTY LIVER-DISEASE; SOLUBLE L-SELECTIN;
   CELL-ADHESION MOLECULE-1; OXIDATIVE STRESS; TRIGLYCERIDE SYNTHESIS;
   NEUTROPHIL ACTIVATION; RHEUMATOID-ARTHRITIS; LEUKOCYTE ADHESION; HEPATIC
   STEATOSIS
AB CD62L (L-Selectin) dependent lymphocyte infiltration is known to induce inflammatory bowel disease (IBD), while its function in the liver, especially in non-alcoholic steatohepatitis (NASH), remains unclear. We here investigated the functional role of CD62L in NASH in humans as well as in two mouse models of steatohepatitis. Hepatic expression of a soluble form of CD62L (sCD62L) was measured in patients with steatosis and NASH. Furthermore, CD62L(-/-) mice were fed with a methionine and choline deficient (MCD) diet for 4 weeks or with a high fat diet (HFD) for 24 weeks. Patients with NASH displayed increased serum levels of sCD62L. Hepatic CD62L expression was higher in patients with steatosis and increased dramatically in NASH patients. Interestingly, compared to wild type (WT) mice, MCD and HFD-treated CD62L(-/-) mice were protected from diet-induced steatohepatitis. This was reflected by less fat accumulation in hepatocytes and a dampened manifestation of the metabolic syndrome with an improved insulin resistance and decreased cholesterol and triglyceride levels. Consistent with ameliorated disease, CD62L(-/-) animals exhibited an enhanced hepatic infiltration of Treg cells and a strong activation of an anti-oxidative stress response. Those changes finally resulted in less fibrosis in CD62L(-/-) mice. Additionally, this effect could be reproduced in a therapeutic setting by administrating an anti-CD62L blocking antibody. CD62L expression in humans and mice correlates with disease activity of steatohepatitis. CD62L knockout and anti-CD62L-treated mice are protected from diet-induced steatohepatitis suggesting that CD62L is a promising target for therapeutic interventions in NASH.
C1 [Drescher, Hannah K.; Trautwein, Christian; Kroy, Daniela C.] Rhein Westfal TH Aachen, Univ Hosp, Dept Internal Med 3, D-52074 Aachen, Germany.
   [Drescher, Hannah K.] Massachusetts Gen Hosp, Div Gastroenterol, Boston, MA 02114 USA.
   [Drescher, Hannah K.] Harvard Med Sch, Boston, MA 02114 USA.
   [Schippers, Angela; Eswaran, Sreepradha; Wagner, Norbert] Rhein Westfal TH Aachen, Univ Hosp, Dept Pediat, D-52074 Aachen, Germany.
   [Rosenhain, Stefanie; Gremse, Felix] Rhein Westfal TH Aachen, Univ Hosp, Inst Expt Mol Imaging, D-52074 Aachen, Germany.
   [Bongiovanni, Laura; de Bruin, Alain] Univ Utrecht, Dept Pathobiol, Dutch Mol Pathol Ctr, Fac Vet Med, NL-3508 Utrecht, Netherlands.
   [Gallage, Suchira U.; Pfister, Dominik; Szydlowska, Marta; Heikenwalder, Mathias] German Canc Res Ctr Heidelberg DKFZ, Div Chron Inflammat & Canc, D-69120 Heidelberg, Germany.
   [Weiskirchen, Sabine; Weiskirchen, Ralf] Rhein Westfal TH Aachen, Univ Hosp, Inst Mol Pathobiochem Expt Gene Therapy & Clin Ch, D-52074 Aachen, Germany.
C3 RWTH Aachen University; RWTH Aachen University Hospital; Harvard
   University; Harvard University Medical Affiliates; Massachusetts General
   Hospital; Harvard University; Harvard Medical School; RWTH Aachen
   University; RWTH Aachen University Hospital; RWTH Aachen University;
   RWTH Aachen University Hospital; Utrecht University; Helmholtz
   Association; German Cancer Research Center (DKFZ); RWTH Aachen
   University; RWTH Aachen University Hospital
RP Drescher, HK (corresponding author), Rhein Westfal TH Aachen, Univ Hosp, Dept Internal Med 3, D-52074 Aachen, Germany.; Drescher, HK (corresponding author), Massachusetts Gen Hosp, Div Gastroenterol, Boston, MA 02114 USA.; Drescher, HK (corresponding author), Harvard Med Sch, Boston, MA 02114 USA.
EM hdrescher@mgh.harvard.edu; anschippers@ukaachen.de;
   seswaran@ukaachen.de; fgremse@ukaachen.de; l.bongiovanni@uu.nl;
   a.debruin@uu.nl; seswaran@ukaachen.de;
   suchira.gallage@med.uni-heidelberg.de;
   dominik.pfister@med.uni-heidelberg.de;
   marta.szydlowska@med.uni-heidelberg.de;
   mathias.heikenwaelder@med.uni-heidelberg.de; sweiskirchen@ukaachen.de;
   nwagner@ukaachen.de; ctrautwein@ukaachen.de; rweiskirchen@ukaachen.de;
   danielakroy@gmail.com
RI de Bruin, Alain/AAL-9195-2020; Pfister, Dominik/AAK-7358-2021; Gallage,
   Suchira/LBI-2904-2024; Weiskirchen, Ralf/O-1734-2018
OI Rosenhain, Stefanie/0000-0003-2471-7551; Weiskirchen,
   Ralf/0000-0003-3888-0931; de Bruin, Alain/0000-0001-8579-2649;
   Szydlowska, Marta/0000-0002-4660-899X; Gallage,
   Suchira/0000-0002-1956-3597; Drescher, Hannah/0000-0001-9945-1239;
   Pfister, Dominik/0000-0002-0542-2638
FU Deutsche Forschungsgemeinschaft [SFB/TRR 57, SCHI1170/2-1, CRC1382];
   Interdisciplinary Centre for Clinical Research within the Faculty of
   Medicine at the RWTH Aachen University [O3-1]; ERC CoG grant
   HEPATO-METABO-PATH
FX This work was supported by grants from the Deutsche
   Forschungsgemeinschaft (SFB/TRR 57 to RW, CT and DCK; SCHI1170/2-1 to
   AS; CRC1382 to NW, AS and project Q1 to FG and SR). Further support was
   granted by the Interdisciplinary Centre for Clinical Research within the
   Faculty of Medicine at the RWTH Aachen University (O3-1) and the ERC CoG
   grant HEPATO-METABO-PATH.
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NR 71
TC 15
Z9 17
U1 0
U2 4
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2073-4409
J9 CELLS-BASEL
JI Cells
PD MAY
PY 2020
VL 9
IS 5
DI 10.3390/cells9051106
PG 24
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA LW7RF
UT WOS:000539340200040
PM 32365632
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Bessone, F
   Dirchwolf, M
   Rodil, MA
   Razori, MV
   Roma, MG
AF Bessone, Fernando
   Dirchwolf, Melisa
   Agustina Rodil, Maria
   Valeria Razori, Maria
   Roma, Marcelo G.
TI Review article: drug-induced liver injury in the context of nonalcoholic
   fatty liver disease - a physiopathological and clinical integrated view
SO ALIMENTARY PHARMACOLOGY & THERAPEUTICS
LA English
DT Review
ID MITOCHONDRIAL PERMEABILITY TRANSITION; ENDOPLASMIC-RETICULUM STRESS;
   HEPATIC STELLATE CELLS; TERM METHOTREXATE TREATMENT; UNFOLDED PROTEIN
   RESPONSE; NECROSIS-FACTOR-ALPHA; NF-KAPPA-B; OXIDATIVE STRESS; VALPROIC
   ACID; LONG-TERM
AB Background: Nonalcoholic fatty disease (NAFLD) is the most common liver disease, since it is strongly associated with obesity and metabolic syndrome pandemics. NAFLD may affect drug disposal and has common pathophysiological mechanisms with drug-induced liver injury (DILI); this may predispose to hepatoxicity induced by certain drugs that share these pathophysiological mechanisms. In addition, drugs may trigger fatty liver and inflammation per se by mimicking NAFLD pathophysiological mechanisms.
   Aims: To provide a comprehensive update on (a) potential mechanisms whereby certain drugs can be more hepatotoxic in NAFLD patients, (b) the steatogenic effects of drugs, and (c) the mechanism involved in drug-induced steatohepatitis (DISH).
   Methods: A language- and date-unrestricted Medline literature search was conducted to identify pertinent basic and clinical studies on the topic.
   Results: Drugs can induce macrovesicular steatosis by mimicking NAFLD pathogenic factors, including insulin resistance and imbalance between fat gain and loss. Other forms of hepatic fat accumulation exist, such as microvesicular steatosis and phospholipidosis, and are mostly associated with acute mitochondrial dysfunction and defective lipophagy, respectively. Drug-induced mitochondrial dysfunction is also commonly involved in DISH. Patients with pre-existing NAFLD may be at higher risk of DILI induced by certain drugs, and polypharmacy in obese individuals to treat their comorbidities may be a contributing factor.
   Conclusions: The relationship between DILI and NAFLD may be reciprocal: drugs can cause NAFLD by acting as steatogenic factors, and pre-existing NAFLD could be a predisposing condition for certain drugs to cause DILI. Polypharmacy associated with obesity might potentiate the association between this condition and DILI.
C1 [Bessone, Fernando; Agustina Rodil, Maria] Univ Nacl Rosario, Hosp Prov Centenario, Fac Ciencias Med, Serv Gastroenterol & Hepatol, Rosario, Santa Fe, Argentina.
   [Dirchwolf, Melisa] Hosp Privado Rosario, Unidad Transplante Hepat, Serv Hepatol, Rosario, Santa Fe, Argentina.
   [Valeria Razori, Maria; Roma, Marcelo G.] Univ Nacl Rosario, Fac Ciencias Bioquim & Farmaceut, Inst Fisiol Expt IFISE CONICET, Rosario, Santa Fe, Argentina.
C3 National University of Rosario; Consejo Nacional de Investigaciones
   Cientificas y Tecnicas (CONICET); National University of Rosario
RP Roma, MG (corresponding author), UNR, Fac Ciencias Bioquim & Farmaceut, Inst Fisiol Expt IFISE, Suipacha 570, RA-2000 Rosario, Santa Fe, Argentina.; Bessone, F (corresponding author), Univ Nacl Rosario, Serv Gastroenterol & Hepatol, Fac Ciencias Med, Urquiza 3101, RA-2000 Rosario, Santa Fe, Argentina.
EM bessonefernando@gmail.com; mroma@fbioyf.unr.edu.ar
OI Roma, Marcelo Gabriel/0000-0002-1660-9801; Razori, Maria
   Valeria/0000-0002-2518-119X
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NR 308
TC 71
Z9 74
U1 1
U2 27
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0269-2813
EI 1365-2036
J9 ALIMENT PHARM THER
JI Aliment. Pharmacol. Ther.
PD NOV
PY 2018
VL 48
IS 9
BP 892
EP 913
DI 10.1111/apt.14952
PG 22
WC Gastroenterology & Hepatology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Pharmacology & Pharmacy
GA GW8WX
UT WOS:000447263100001
PM 30194708
OA Bronze
DA 2025-06-11
ER

PT J
AU Baye, E
   Ukropec, J
   de Courten, MPJ
   Mousa, A
   Kurdiova, T
   Johnson, J
   Wilson, K
   Plebanski, M
   Aldini, G
   Ukropcova, B
   de Courten, B
AF Baye, Estifanos
   Ukropec, Jozef
   de Courten, Maximilian P. J.
   Mousa, Aya
   Kurdiova, Timea
   Johnson, Josphin
   Wilson, Kirsty
   Plebanski, Magdalena
   Aldini, Giancarlo
   Ukropcova, Barbara
   de Courten, Barbora
TI Carnosine Supplementation Improves Serum Resistin Concentrations in
   Overweight or Obese Otherwise Healthy Adults: A Pilot Randomized Trial
SO NUTRIENTS
LA English
DT Article
DE carnosine; adipokines; obesity; type 2 diabetes; cardiovascular disease
ID GLYCATION END-PRODUCTS; INSULIN-RESISTANCE; INFLAMMATORY MARKERS;
   OXIDATIVE STRESS; CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; CARBONYL
   STRESS; LIVER-INJURY; ADIPOKINES; HISTIDINE
AB Adipokines play an important role in the regulation of glucose metabolism. We have previously shown that carnosine supplementation in overweight or obese non-diabetic individuals improves glucose metabolism but does not change adiponectin concentrations. However, its effect on other adipokines has not been investigated. Herein we further determined the effect of carnosine supplementation on serum adipsin, resistin and leptin. Twenty-two overweight or obese otherwise healthy adults were randomly assigned to receive either 2 g of carnosine (n = 13) or identically looking placebo (n = 9) for 12 weeks. Serum adipsin, leptin and resistin were analyzed using a bead-based multiplex assay. Carnosine supplementation decreased serum resistin concentrations compared to placebo (mean change from baseline: -35 +/- 83 carnosine vs. 35 +/- 55 ng/mL placebo, p = 0.04). There was a trend for a reduction in serum leptin concentrations after carnosine supplementation (-76 +/- 165 ng/mL carnosine vs. 20 +/- 28 ng/mL placebo, p = 0.06). The changes in leptin and resistin concentrations were inversely related to the change in concentration for urinary carnosine (r = -0.72, p = 0.0002; r = -0.67, p = 0.0009, respectively), carnosine-propanal (r = -0.56, p = 0.005; r = -0.63, p = 0.001, respectively) and carnosine-propanol (r = -0.61, p = 0.002; r = -0.60, p = 0.002, respectively). There were no differences between groups in change in adipsin concentrations. Our findings show carnosine supplementation may normalize some, but not all, of the serum adipokine concentrations involved in glucose metabolism, in overweight and obese individuals. Further clinical trials with larger samples are needed to confirm these results.
C1 [Baye, Estifanos; Mousa, Aya; Johnson, Josphin; de Courten, Barbora] Monash Univ, Sch Publ Hlth & Prevent Med, Monash Ctr Hlth Res & Implementat, Melbourne, Vic 3168, Australia.
   [Ukropec, Jozef; Kurdiova, Timea; Ukropcova, Barbara] Slovak Acad Sci, Biomed Res Ctr, Inst Expt Endocrinol, Bratislava 84236, Slovakia.
   [de Courten, Maximilian P. J.] Victoria Univ, Coll Hlth & Biomed, Ctr Chron Dis, Melbourne, Vic 3800, Australia.
   [Wilson, Kirsty; Plebanski, Magdalena] Monash Univ, Dept Pathol & Immunol, Melbourne, Vic 3168, Australia.
   [Plebanski, Magdalena] RMIT Univ, Sch Hlth & Biomed Sci, Melbourne, Vic 3001, Australia.
   [Aldini, Giancarlo] Univ Milan, Dept Pharmaceut Sci, I-20133 Milan, Italy.
   [Ukropcova, Barbara] Comenius Univ, Inst Pathol Physiol, Fac Med, Bratislava 84215, Slovakia.
C3 Monash University; Slovak Academy of Sciences; Biomedical Research
   Center, SAS; Institute of Experimental Endocrinology, SAS; Victoria
   University; Monash University; Royal Melbourne Institute of Technology
   (RMIT); University of Milan; Comenius University Bratislava
RP de Courten, B (corresponding author), Monash Univ, Sch Publ Hlth & Prevent Med, Monash Ctr Hlth Res & Implementat, Melbourne, Vic 3168, Australia.
EM estifanos.baye@monash.edu; jozef.ukropec@gmail.com;
   Maximilian.deCourten@vu.edu.au; aya.mousa@monash.edu;
   timea.kurdiova@savba.sk; josphin.johnson@monash.edu;
   kirsty.wilson@monash.edu; magdalena.plebanski@monash.edu;
   giancarlo.aldini@unimi.it; barbara.ukropcova@gmail.com;
   barbora.decourten@monash.edu
RI Plebanski, Magdalena/AAU-3144-2021; de Courten, Barbora/B-3308-2012;
   Ukropcova, Barbara/ABE-6186-2020; Mousa, Aya/AFU-5166-2022; aldini,
   giancarlo/C-3533-2013; Ukropec, Jozef/D-5960-2018; de Courten,
   Maximilian/B-3300-2012
OI Ukropec, Jozef/0000-0001-8401-6621; Kurdiova, Timea/0000-0003-1686-3647;
   de Courten, Maximilian/0000-0001-9997-9359; Baye,
   Estifanos/0000-0002-2937-356X; Ukropcova, Barbara/0000-0002-3309-7713;
   Mousa, Aya/0000-0002-7356-4523; Plebanski, Magdalena/0000-0001-6889-3667
FU Grant Agency of the Slovak Academy of Sciences [VEGA 2/191/15]; Slovak
   Research and Development Agency [SRDA 15/0253]; Diabetes Australia
   Research Trust; Foundation for High Blood Pressure Research; Monash
   Graduate Scholarship; Monash University; National Heart Foundation
   Future Leader Fellowship [100864]; Royal Australasian College of
   Physicians; Monash International Postgraduate Scholarship
FX We thank the volunteers for their participation in the trial. We also
   thank Professor Wim Derave for analyzing the carnosinase measurements.
   This study was supported by the Grant Agency of the Slovak Academy of
   Sciences VEGA 2/191/15, Slovak Research and Development Agency SRDA
   15/0253, Royal Australasian College of Physicians, Diabetes Australia
   Research Trust and Foundation for High Blood Pressure Research.
   Carnosine supplement was received from Flamma S.p.A, Italy. E.B. is a
   recipient of the Monash Graduate and Monash International Postgraduate
   Scholarships. A.M. is a recipient of an Australian Postgraduate Award
   provided by Monash University. B.d.C. is supported by a National Heart
   Foundation Future Leader Fellowship (100864). No funder had any role in
   the study design, data collection, data analysis or interpretation, or
   writing of the manuscript.
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NR 50
TC 20
Z9 21
U1 0
U2 3
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD SEP
PY 2018
VL 10
IS 9
AR 1258
DI 10.3390/nu10091258
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA GY5YI
UT WOS:000448659900131
PM 30205427
OA Green Submitted, gold, Green Published, Green Accepted
DA 2025-06-11
ER

PT J
AU Scrimgeour, LA
   Potz, BA
   Elmadhun, NY
   Chu, LM
   Sellke, FW
AF Scrimgeour, Laura A.
   Potz, Brittany A.
   Elmadhun, Nassrene Y.
   Chu, Louis M.
   Sellke, Frank W.
TI Alcohol attenuates myocardial ischemic injury
SO SURGERY
LA English
DT Article
ID LEPTIN LEVELS; SWINE MODEL; RED WINE; INFARCTION; PHOSPHORYLATION;
   INFLAMMATION; CONSUMPTION; REPAIR; VODKA; HEART
AB Background. Moderate alcohol consumption is cardioprotective but the mechanism of action remains unclear. Nuclear factor kappa-B regulates the expression of genes involved in inflammation, stress, and apoptosis. We used a swine model of diet-induced metabolic syndrome to investigate the effects of red wine and vodka on nuclear factor kappa-B signaling and cytokine activity in chronically ischemic myocardium.
   Methods. Yorkshire swine were given a high-fat diet for 4 weeks; an ameroid constrictor was then placed on the left circumflex artery. The high-fat diet was continued and the swine were divided into 3 groups for 7 weeks: hypercholesterolemic diet alone (control, n = 8), hypercholesterolemic diet with vodka (vodka, n = 8), and hypercholesterolemic diet with wine (wine, n = 8). Ischemic myocardium was analyzed by Western blot and cytokine array.
   Results. Administration of alcohol was associated with decreased expression of inhibitor of kappa-B kinase complex a, inhibitor of kappa-B kinase complex beta, and phosphorylated inhibitor of kappa-B beta in the ischemic myocardium compared with the control group. Alcohol administration demonstrated an increase in nuclear factor K-B in the ischemic myocardium. Both wine and vodka demonstrated a significant decrease in leptin, interleukin-1 alpha, IL-13, IL-15, and interferon-gamma. Vodka demonstrated a significant decrease in phosphorylated BCL-2 and caspase-9.
   Conclusion. In ischemic myocardium, alcohol modulates the nuclear factor kappa-B pathway, which may contribute to the adaptive response of tissues to the stress of ischemia. Furthermore, both wine and vodka decreased multiple proinflammatory cytokines. This study provides a mechanism by which alcohol may be cardioprotective in ischemic myocardium.
C1 [Scrimgeour, Laura A.; Potz, Brittany A.; Elmadhun, Nassrene Y.; Chu, Louis M.; Sellke, Frank W.] Brown Univ, Dept Surg, Warren Alpert Sch Med, Div Cardiothorac Surg,Lifespan Hosp, 2 Dudley St,MOC 360, Providence, RI 02905 USA.
C3 Lifespan Health Rhode Island; Brown University
RP Sellke, FW (corresponding author), Brown Univ, Dept Surg, Warren Alpert Sch Med, Div Cardiothorac Surg,Lifespan Hosp, 2 Dudley St,MOC 360, Providence, RI 02905 USA.
EM fsellke@Iifespan.org
FU National Heart, Lung, and Blood Institute [R01HL46716, R01HL69024]; NIH
   [T32 GM065085-12]; NIH/NIGMS [2T32 GM065085, 5T32-HL094300-03]
FX Supported in part by the National Heart, Lung, and Blood Institute
   (R01HL46716, R01HL69024) to Dr Sellke; NIH T32 GM065085-12 training
   grant to Dr Scrimgeour; NIH/NIGMS training grant 2T32 GM065085 to Dr
   Potz, and T32 funding grant 5T32-HL094300-03 to Dr Elmadhun.
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NR 27
TC 4
Z9 4
U1 0
U2 5
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0039-6060
J9 SURGERY
JI Surgery
PD SEP
PY 2017
VL 162
IS 3
BP 680
EP 687
DI 10.1016/j.surg.2017.04.014
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA FE7RE
UT WOS:000408403800022
PM 28602493
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Ma, KL
   Zhang, Y
   Liu, J
   Wu, Y
   Hu, ZB
   Ruan, XZ
   Liu, BC
AF Ma, Kun Ling
   Zhang, Yang
   Liu, Jing
   Wu, Yu
   Hu, Ze Bo
   Ruan, Xiong Zhong
   Liu, Bi Cheng
TI Establishment of an Inflamed Animal Model of Diabetic Nephropathy
SO INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
LA English
DT Article
DE Diabetic nephropathy; inflammation; db/db mice; animal model
ID RENAL INJURY; INSULIN-RESISTANCE; METABOLIC SYNDROME; KNOCKOUT MICE;
   INFLAMMATION; ASSOCIATION; PODOCYTE
AB Aims Inflammatory stress plays a crucial role in the progression of diabetic nephropathy (DN). This study aimed to establish a novel inflamed animal model of DN and to evaluate its significance in DN.
   Methods Nondiabetic db/m mice and diabetic db/db mice were randomly divided into four groups: db/m, db/m+casein, db/db, and db/db+casein for eight weeks. Casein was subcutaneously injected to induce chronic inflammation. Body weight and albumin to creatinine ratio (ACR) in the urine were measured every week. The plasma levels of serum amyloid protein A (SAA) and tumour necrotic factor-alpha (TNF-alpha) were determined with the enzyme-linked immunosorbent assay. The morphological changes to the renal pathology and ultra-microstructures were checked by pathological staining and electron microscopy. Immunofluorescent staining and Western blotting were used to determine the protein expression of podocyte-specific molecules and inflammatory cytokines in kidneys.
   Results ACR, plasma levels of SAA and TNF-alpha, protein expression of inflammatory cytokines, mesangial expansion, collagen accumulation, and foot process effacement in kidneys of casein-injected db/db mice were significantly increased compared with the db/db mice. Casein injection markedly decreased the protein expression of Wilms' tumor-1 and nephrin in kidneys of db/db mice, which are specific podocyte biomarkers, suggesting that chronic inflammation accelerates podocyte injuries in db/db mice. Interestingly, no obvious urinary protein, inflammatory cytokine expression, or histological changes in the kidneys of casein-injected db/m mice were found compared with the db/m mice.
   Conclusion An inflamed animal model of DN was successfully established and may provide a useful tool for investigating the pathogenesis of DN under inflammatory stress.
C1 [Ma, Kun Ling; Zhang, Yang; Liu, Jing; Wu, Yu; Hu, Ze Bo; Liu, Bi Cheng] Southeast Univ, Sch Med, Zhong Da Hosp, Inst Nephrol, Nanjing 210009, Jiangsu, Peoples R China.
   [Ruan, Xiong Zhong] UCL, Sch Med, Ctr Nephrol, London WC1E 6BT, England.
C3 Southeast University - China; University of London; University College
   London; UCL Medical School
RP Ma, KL (corresponding author), Southeast Univ, Sch Med, Zhong Da Hosp, Inst Nephrol, 87 Ding Jia Qiao Rd, Nanjing 210009, Jiangsu, Peoples R China.
EM mmkkll@hotmail.com
RI zhang, yangge/LTZ-5684-2024; Ruan, Xiong/GZA-5963-2022
FU National Natural Science Foundation of China [81170792, 81070571]
FX This work was supported by Grants 81170792 and 81070571 from the
   National Natural Science Foundation of China.
CR Breyer MD, 2005, J AM SOC NEPHROL, V16, P27, DOI [10.1681/ASN.2004080648, 10.1681/ASN.2009070721]
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NR 18
TC 16
Z9 20
U1 0
U2 20
PU IVYSPRING INT PUBL
PI LAKE HAVEN
PA PO BOX 4546, LAKE HAVEN, NSW 2263, AUSTRALIA
SN 1449-2288
J9 INT J BIOL SCI
JI Int. J. Biol. Sci.
PY 2014
VL 10
IS 2
BP 149
EP 159
DI 10.7150/ijbs.7875
PG 11
WC Biochemistry & Molecular Biology; Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics
GA AA9GJ
UT WOS:000331401500002
PM 24520213
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Rupérez, AI
   López-Guarnido, O
   Gil, F
   Olza, J
   Gil-Campos, M
   Leis, R
   Tojo, R
   Cañete, R
   Gil, A
   Aguilera, CM
AF Ruperez, A. I.
   Lopez-Guarnido, O.
   Gil, F.
   Olza, J.
   Gil-Campos, M.
   Leis, R.
   Tojo, R.
   Canete, R.
   Gil, A.
   Aguilera, C. M.
TI Paraoxonase 1 activities and genetic variation in childhood obesity
SO BRITISH JOURNAL OF NUTRITION
LA English
DT Article
DE Paraoxonase 1 gene; Genetic polymorphisms; Obesity; Children
ID LOW-DENSITY-LIPOPROTEIN; SERUM PARAOXONASE; OXIDATIVE STRESS;
   ARYLESTERASE ACTIVITIES; CARDIOVASCULAR RISK; METABOLIC SYNDROME; PON1
   ACTIVITY; POLYMORPHISMS; INFLAMMATION; ASSOCIATION
AB Changes in paraoxonase 1 (PON1) activities have been observed in a variety of diseases involving oxidative stress, such as CVD. However, its role in obesity has not been fully established. In the present study, we aimed (1) to genotype sixteen PON1 SNP, (2) to measure serum PON1 activities and (3) to correlate these findings with the incidence of childhood obesity and related traits. We conducted a case-control study of 189 normal-weight and 179 obese prepubertal children, and we measured four different PON1 activities: lactonase; paraoxonase; arylesterase; diazoxonase. Although none of these activities was significantly different between the obese and normal-weight children, lactonase activity was found to be positively correlated with HDL-cholesterol and ApoA1 levels and negatively correlated with myeloperoxidase and fatty acid-binding protein 4 levels. Among the sixteen genotyped PON1 SNP, only the intronic SNP rs854566 exhibited a significant association with obesity (OR 0.61, 95% CI 0.41, 0.91; P=0.016). This genetic variant was also associated with increased diazoxonase, lactonase and arylesterase activities and decreased paraoxonase activity. Other genetic variants exhibited different association patterns with serum activities based on their location within the PON1 gene, and SNP that were located within the promoter were strongly associated with lactonase, arylesterase and diazoxonase activities. The functional variant Q192R exhibited the greatest effect on paraoxonase activity (P=5.88 x 10(-42)). In conclusion, SNP rs854566 was negatively associated with childhood obesity and with increased serum PON1 activities in prepubertal children. We determined that lactonase is a reliable indicator of PON1 activities and should be included in future studies of PON1 function.
C1 [Ruperez, A. I.; Olza, J.; Gil, A.; Aguilera, C. M.] Univ Granada, Dept Biochem & Mol Biol 2, Inst Nutr & Food Technol, Ctr Biomed Res,Lab 123, Granada 18100, Spain.
   [Lopez-Guarnido, O.; Gil, F.] Univ Granada, Dept Legal Med Toxicol & Anthropol, E-18071 Granada, Spain.
   [Gil-Campos, M.; Canete, R.] Reina Sofia Univ Hosp, Unit Paediat Endocrinol, Cordoba 14004, Spain.
   [Leis, R.; Tojo, R.] Univ Santiago de Compostela, Unit Invest Nutr Growth & Human Dev Galicia, Dept Paediat, Clin Univ Hosp Santiago, Santiago De Compostela 15706, Spain.
C3 University of Granada; University of Granada; Hospital Universitario
   Reina Sofia - Cordoba; Universidade de Santiago de Compostela; Complexo
   Hospitalario Universitario de Santiago de Compostela
RP Aguilera, CM (corresponding author), Univ Granada, Dept Biochem & Mol Biol 2, Inst Nutr & Food Technol, Ctr Biomed Res,Lab 123, Ave Conocimiento S-N, Granada 18100, Spain.
EM caguiler@ugr.es
RI Leis, Rosaura/Z-3186-2019; López-Guarnido, Olga/AAB-1526-2019; Rupérez,
   Azahara/L-3771-2019; Olza, Josune/Y-3333-2019; Aguilera,
   Concepcion/M-1663-2014; Gil, Angel/L-2275-2014; Olza, Josune/N-7718-2013
OI Aguilera, Concepcion/0000-0002-1451-4788; Leis,
   Rosaura/0000-0002-0540-4210; Ruperez, Azahara I./0000-0002-3850-8235;
   Gil, Angel/0000-0001-7663-0939; Gil-Campos,
   Mercedes/0000-0002-9007-0242; Olza, Josune/0000-0001-8840-8542
FU Plan Nacional de Investigacion Cientifica, Desarrollo e Innovacion
   Tecnologica (I + D + I); Instituto de Salud Carlos III-Fondo de
   Investigacion Sanitaria (FIS) [PI 020826, PI051968]; Redes tematicas de
   investigacion cooperativa (RETIC) [Red SAMID RD08/0072/0028]; Junta de
   Andalucia, the Consejeria de Innovacion y Ciencia [P06-CTS 2203]; the
   Consejeria de Salud [0098/2005]; Ministerio de Ciencia e Innovacion,
   Campus de Excelencia Internacional de Granada
FX The authors thank the children and parents who participated in the
   study. The present study was funded by the Plan Nacional de
   Investigacion Cientifica, Desarrollo e Innovacion Tecnologica (I + D +
   I), the Instituto de Salud Carlos III-Fondo de Investigacion Sanitaria
   (FIS) (PI 020826, PI051968), Redes tematicas de investigacion
   cooperativa (RETIC) (Red SAMID RD08/0072/0028), Junta de Andalucia, the
   Consejeria de Innovacion y Ciencia (P06-CTS 2203), the Consejeria de
   Salud (0098/2005) and the Ministerio de Ciencia e Innovacion, Campus de
   Excelencia Internacional de Granada. GREIBCTS461. The authors'
   contributions were as follows: F. G., A. G. and C. M. A. conceptualised
   and designed the study; M. G.-C., R. L., R. T. and R. C. were involved
   in the data and sample collection; J. O. carried out the biomarker
   analysis; A. I. R. and O. L.-G. conducted the enzymatic analysis; A. I.
   R. performed the statistical analysis; A. I. R. and C. M. A. wrote the
   manuscript.
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NR 32
TC 27
Z9 28
U1 2
U2 26
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1145
EI 1475-2662
J9 BRIT J NUTR
JI Br. J. Nutr.
PD NOV 14
PY 2013
VL 110
IS 9
BP 1639
EP 1647
DI 10.1017/S0007114513001967
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 250UU
UT WOS:000326882400011
PM 23789921
OA Bronze
DA 2025-06-11
ER

PT J
AU Rosmond, R
   Chagnon, M
   Bouchard, C
   Björntorp, P
AF Rosmond, R
   Chagnon, M
   Bouchard, C
   Björntorp, P
TI A polymorphism in the regulatory region of the corticotropin-releasing
   hormone gene in relation to cortisol secretion, obesity, and gene-gene
   interaction
SO METABOLISM-CLINICAL AND EXPERIMENTAL
LA English
DT Article
ID BODY-FAT DISTRIBUTION; PITUITARY-ADRENAL AXIS; MIDDLE-AGED MEN; SALIVARY
   CORTISOL; ABDOMINAL OBESITY; METABOLIC SYNDROME; STRESS; WOMEN;
   DYSREGULATION; ENDOCRINE
AB In recent years, a considerable body of evidence has emerged regarding the pathogenic role of cortisol in abdominal obesity. The regulation of the corticotropin-releasing hormone (CRH) gene might play an essential role because it is the primary hypothalamic neuropeptide involved in the control of adrenal secretion of cortisol. Therefore, we examined the hypothalamic-pituitary-adrenal function by repeated salivary samples for the assessment of cortisol as well as other endocrine, anthropometric, metabolic, and circulatory variables in middle-aged Swedish men (n = 284). With the restriction enzyme XmnI, a variant in the 5'-flanking region of the CRH gene was identified (T255G). The observed genotype frequencies were 89.9% and 9.7% for T/T and T/G, respectively. Only 1 subject was homozygous for the rare allele (0.4%; G/G). The results showed that the XmnI polymorphism of the CRH gene is not associated with an altered cortisol-secretory pattern or sensitivity to glucocorticoids or with obesity and its related metabolic and circulatory perturbations. However, when the interaction effect between a previously described TthlllI glucocorticold-receptor gene polymorphism and the present XmnI CRH polymorphism was investigated, the cortisol levels before and during physiologic stress and the total diurnal cortisol secretion were significantly increased among subjects who were carriers for both variants. From these results, we conclude that an abnormal production rate of the CRH gene product in the presence of an inadequate glucocorticoid receptor density might lead to elevated cortisol levels. Copyright (C) 2001 by W.B. Saunders Company.
C1 Univ Gothenburg, Dept Heart & Lung Dis, Gothenburg, Sweden.
   Louisiana State Univ, Pennington Biomed Res Ctr, Baton Rouge, LA 70808 USA.
C3 University of Gothenburg; Louisiana State University System; Louisiana
   State University; Pennington Biomedical Research Center
RP Sahlgrens Univ Hosp, Dept Heart & Lung Dis, S-41345 Gothenburg, Sweden.
RI Bouchard, Claude/AAE-2035-2019; Bouchard, Claude/A-7637-2009
OI Bouchard, Claude/0000-0002-0048-491X
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NR 38
TC 23
Z9 24
U1 0
U2 0
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0026-0495
EI 1532-8600
J9 METABOLISM
JI Metab.-Clin. Exp.
PD SEP
PY 2001
VL 50
IS 9
BP 1059
EP 1062
DI 10.1053/meta.2001.25598
PG 4
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 472DG
UT WOS:000170967600014
PM 11555839
DA 2025-06-11
ER

PT J
AU Hackett, G
   Cole, N
   Bhartia, M
   Kennedy, D
   Raju, J
   Wilkinson, P
   Saghir, A
AF Hackett, G.
   Cole, N.
   Bhartia, M.
   Kennedy, D.
   Raju, J.
   Wilkinson, P.
   Saghir, A.
CA BLAST STUDY GRP
TI The response to testosterone undecanoate in men with type 2 diabetes is
   dependent on achieving threshold serum levels (the BLAST study)
SO INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
LA English
DT Article
ID LATE-ONSET HYPOGONADISM; CARDIOVASCULAR-DISEASE; ERECTILE DYSFUNCTION;
   REPLACEMENT THERAPY; METABOLIC SYNDROME; GLYCEMIC CONTROL; OLDER MEN;
   MORTALITY; PLACEBO; SUPPLEMENTATION
AB BackgroundThe association between testosterone deficiency and insulin resistance in men with type 2 diabetes is well established. Current Endocrine Society and European Association of Urology guidelines recommend the measurement of testosterone levels in all men with type 2 diabetes and in men suffering from erectile dysfunction. It is recognised that a range of physical symptoms appear as the testosterone level falls but few studies have addressed the threshold at which symptoms improve with physiological replacement. We report the first double-blind placebo-controlled study conducted exclusively in a male type 2 diabetes population to assess the metabolic changes with testosterone replacement.
   MethodsThe type 2 diabetes registers of seven general practices were screened to establish the prevalence of low testosterone and the associations with diabetes control. Of 550 eligible patients approached, 488 men (mean age 62.6) consented to take part in screening with a morning testosterone level, assessed between 8 and 11 am. This identified 211 patients for a double-blind placebo-controlled study of long acting testosterone undecanoate (TU) 1000mg lasting 30weeks followed by 52weeks of open label use. The population was divided into a SEVERE group with either total testosterone (TT) of 8nmol/l or less or free testosterone (FT) 180pmol/l or less or a MILD group with TT 8.1-12nmol/l or FT 181-250pmol/l.
   ResultsMen in the SEVERE group increased mean through TT from 7.73nmol/l at baseline to 9.93 at 30weeks and the MILD group from 10.47 to 11.94. The SEVERE group showed marked improvement in sexual function, but no significant improvement in metabolic parameters. The MILD group showed no improvement in sexual function, but significant improvement in weight, body mass index, waist circumference and Hospital Anxiety and Depression Scale. Improvement was seen in all parameters during 52weeks open label treatment where trough TT levels approached 15nmol/l. Baseline prostate-specific antigen (PSA) was lower in the SEVERE group and increased with TU for 30weeks and then stabilised. There was no increase in PSA with treatment in the MILD group.
   ConclusionsTestosterone undecanoate significantly improves sexual parameters and Ageing Male Symptom Score, but not metabolic factors at 30weeks in men with SEVERE testosterone deficiency syndrome (TDS). In men with MILD TDS, significant improvements in metabolic but not sexual parameters were seen, suggesting that there are threshold levels for response to testosterone replacement therapy and that trials of therapy need to achieve sustained therapeutic levels to be effective. PSA showed minor rises, but only for 30weeks in the SEVERE group.
C1 [Hackett, G.; Cole, N.; Bhartia, M.; Kennedy, D.; Raju, J.] Good Hope Hosp, Sutton, Coldfield, England.
   [Saghir, A.] Univ Birmingham, Birmingham, W Midlands, England.
C3 Heart of England NHS Foundation Trust; Good Hope Hospital; University of
   Birmingham
RP Hackett, G (corresponding author), Holly Cottage Clin, Fisherwick WS14 9JL, Lichfield, England.
EM geoff.hackett@virgin.net
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NR 45
TC 75
Z9 78
U1 0
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1368-5031
EI 1742-1241
J9 INT J CLIN PRACT
JI Int. J. Clin. Pract.
PD FEB
PY 2014
VL 68
IS 2
BP 203
EP 215
DI 10.1111/ijcp.12235
PG 13
WC Medicine, General & Internal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Pharmacology & Pharmacy
GA 295JX
UT WOS:000330113500011
PM 24355040
DA 2025-06-11
ER

PT J
AU Atehortua, A
   Gkontra, P
   Camacho, M
   Diaz, O
   Bulgheroni, M
   Simonetti, V
   Chadeau-Hyam, M
   Felix, JF
   Sebert, S
   Lekadir, K
AF Atehortua, Angelica
   Gkontra, Polyxeni
   Camacho, Marina
   Diaz, Oliver
   Bulgheroni, Maria
   Simonetti, Valentina
   Chadeau-Hyam, Marc
   Felix, Janine F.
   Sebert, Sylvain
   Lekadir, Karim
TI Cardiometabolic risk estimation using exposome data and machine learning
SO INTERNATIONAL JOURNAL OF MEDICAL INFORMATICS
LA English
DT Article
DE Exposure data; Cardiovascular disease; Type 2 diabetes; XGBoost;
   Explainability; Fairness
ID LIFE-STYLE; CARDIOVASCULAR RISK; CARE; PREVENTION; PREDICTION; HEALTH;
   ENVIRONMENT; VALIDATION; IMPUTATION; DERIVATION
AB Background: The human exposome encompasses all exposures that individuals encounter throughout their lifetime. It is now widely acknowledged that health outcomes are influenced not only by genetic factors but also by the interactions between these factors and various exposures. Consequently, the exposome has emerged as a significant contributor to the overall risk of developing major diseases, such as cardiovascular disease (CVD) and diabetes. Therefore, personalized early risk assessment based on exposome attributes might be a promising tool for identifying high-risk individuals and improving disease prevention.Objective: Develop and evaluate a novel and fair machine learning (ML) model for CVD and type 2 diabetes (T2D) risk prediction based on a set of readily available exposome factors. We evaluated our model using internal and external validation groups from a multi-center cohort. To be considered fair, the model was required to demonstrate consistent performance across different sub-groups of the cohort. Methods: From the UK Biobank, we identified 5,348 and 1,534 participants who within 13 years from the baseline visit were diagnosed with CVD and T2D, respectively. An equal number of participants who did not develop these pathologies were randomly selected as the control group. 109 readily available exposure variables from six different categories (physical measures, environmental, lifestyle, mental health events, sociodemographics, and early-life factors) from the participant's baseline visit were considered. We adopted the XGBoost ensemble model to predict individuals at risk of developing the diseases. The model's performance was compared to that of an integrative ML model which is based on a set of biological, clinical, physical, and sociodemographic variables, and, additionally for CVD, to the Framingham risk score. Moreover, we assessed the proposed model for potential bias related to sex, ethnicity, and age. Lastly, we interpreted the model's results using SHAP, a state-of-the-art explainability method. Results: The proposed ML model presents a comparable performance to the integrative ML model despite using solely exposome information, achieving a ROC-AUC of 0.78 +/- 0.01 and 0.77 +/- 0.01 for CVD and T2D, respectively. Additionally, for CVD risk prediction, the exposome-based model presents an improved performance over the traditional Framingham risk score. No bias in terms of key sensitive variables was identified.Conclusions: We identified exposome factors that play an important role in identifying patients at risk of CVD and T2D, such as naps during the day, age completed full-time education, past tobacco smoking, frequency of tiredness/unenthusiasm, and current work status. Overall, this work demonstrates the potential of exposome-based machine learning as a fair CVD and T2D risk assessment tool.
C1 [Atehortua, Angelica; Gkontra, Polyxeni; Camacho, Marina; Diaz, Oliver; Lekadir, Karim] Univ Barcelona, BCN AIM Lab, Fac Matematiques & Informat, Barcelona, Spain.
   [Bulgheroni, Maria; Simonetti, Valentina] R&D Ab Acus srl, Milan, Italy.
   [Chadeau-Hyam, Marc] Imperial Coll London, MRC HPA Ctr Environm & Hlth, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England.
   [Felix, Janine F.] Univ Med Ctr Rotterdam, Generat R Study Grp, Erasmus MC, Rotterdam, Netherlands.
   [Felix, Janine F.] Univ Med Ctr Rotterdam, Dept Pediat, Erasmus MC, Rotterdam, Netherlands.
   [Sebert, Sylvain] Univ Oulu, Fac Med, Res Unit Populat Hlth, Oulu, Finland.
C3 University of Barcelona; Imperial College London; Erasmus University
   Rotterdam; Erasmus MC; Erasmus University Rotterdam; Erasmus MC;
   University of Oulu
RP Atehortua, A (corresponding author), Univ Barcelona, BCN AIM Lab, Fac Matematiques & Informat, Barcelona, Spain.
EM amatehortual@ub.edu
RI Gkontra, Polyxeni/ISB-4430-2023; Chadeau, Marc/AAN-7586-2021; Simonetti,
   Valentina/MBI-1498-2025
OI Gkontra, Polyxeni/0000-0001-8828-6143; Chadeau-Hyam,
   Marc/0000-0001-8341-5436; Atehortua Labrador, Angelica
   Maria/0000-0002-6192-1757; Simonetti, Valentina/0000-0001-7013-1338;
   Camacho, Marina/0009-0001-7488-385X
FU European Union [825903, 874739]
FX This work has received funding by the European Union's Horizon 2020
   research and innovation programme under grant agreement No 874739
   (LongITools project). PG and KL have additionally received funding by
   the European Union's Horizon 2020 research and innovation programme
   under grant agreement No 825903 (euCanSHare project).
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NR 52
TC 10
Z9 11
U1 3
U2 15
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 1386-5056
EI 1872-8243
J9 INT J MED INFORM
JI Int. J. Med. Inform.
PD NOV
PY 2023
VL 179
AR 105209
DI 10.1016/j.ijmedinf.2023.105209
PG 12
WC Computer Science, Information Systems; Health Care Sciences & Services;
   Medical Informatics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Computer Science; Health Care Sciences & Services; Medical Informatics
GA FG2Q8
UT WOS:001144548300001
PM 37729839
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Li, YS
   Xie, LY
   Song, WJ
   Chen, SD
   Cheng, Y
   Gao, Y
   Huang, MT
   Yan, XM
   Yang, SL
AF Li, Yingsi
   Xie, Luoying
   Song, Wenjing
   Chen, Shudi
   Cheng, Yu
   Gao, Yuan
   Huang, Meiting
   Yan, Xiaoming
   Yang, Songlin
TI Association between dyslipidaemia and dry eye disease: a systematic
   review and meta-analysis
SO BMJ OPEN
LA English
DT Review
DE corneal and external diseases; medical ophthalmology; information
   management
ID MEIBOMIAN GLAND DYSFUNCTION; RISK-FACTORS; METABOLIC SYNDROME;
   COMORBIDITIES; DEFINITION; DEPRESSION; PREVALENCE; NUTRITION
AB Purpose To report a systematic review and meta-analysis of the association between dry eye disease (DED) and dyslipidaemia.
   Methods PubMed, Embase, Web of Science and Cochrane Library were systematically searched from January 2000 to December 2021. We included observational studies to assess the correlation of DED with meibomian gland dysfunction and dyslipidaemia without any language restrictions. The pooled OR with 95% CI was calculated in Stata V.15.
   Results Of 6727 identified studies, 18 studies (21 databases) with a total of 2 663 126 patients were analysed in our meta-analysis. The results showed that DED risk was associated with dyslipidaemia (OR=1.53, 95%CI: 1.41 to 1.66, p=0.001), especially elevated total cholesterol levels (OR=1.57, 95%CI: 1.25 to 1.99, p<0.001), elevated low-density lipoprotein cholesterol levels (OR=1.13, 95%CI: 1.06 to 1.20, p<0.001) and high-density lipoprotein cholesterol levels (OR=1.06, 95%CI: 1.01 to 1.11, p<0.001), but not with serum triglyceride levels. Moreover, having a history of lipid-lowering drug use (OR=1.41, 95%CI: 1.19 to 1.67, p<0.001) was also found to be positively associated with DED risk.
   Conclusions The findings suggested that dyslipidaemia and lipid-lowering drug use might be associated with an increased risk of DED. More evidence is needed to confirm the findings by prospective studies.
C1 [Li, Yingsi; Xie, Luoying; Song, Wenjing; Chen, Shudi; Cheng, Yu; Gao, Yuan; Huang, Meiting; Yan, Xiaoming; Yang, Songlin] Peking Univ First Hosp, Dept Ophthalmol, Beijing, Peoples R China.
RP Yang, SL (corresponding author), Peking Univ First Hosp, Dept Ophthalmol, Beijing, Peoples R China.
EM songlin.yang@foxmail.com
RI Yan, Xiaoming/C-1354-2014; Song, Wenjing/HJJ-0894-2023
FU National Natural Science Foundation of China [81870629]
FX This work was supported by the National Natural Science Foundation of
   China (no. 81870629).
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   Wang SM, 2019, INVEST OPHTH VIS SCI, V60, P1028, DOI 10.1167/iovs.18-25845
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   Wu Y, 2020, OCUL SURF, V18, P267, DOI 10.1016/j.jtos.2020.02.009
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NR 39
TC 3
Z9 3
U1 0
U2 3
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2044-6055
J9 BMJ OPEN
JI BMJ Open
PD NOV
PY 2023
VL 13
IS 11
AR e069283
DI 10.1136/bmjopen-2022-069283
PG 9
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA KR3B3
UT WOS:001181643400004
PM 37989379
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Garg, A
   Neuren, E
   Cha, D
   Kirby, JS
   Ingram, JR
   Jemec, GBE
   Esmann, S
   Thorlacius, L
   Villumsen, B
   del Marmol, V
   Nassif, A
   Delage, M
   Tzellos, T
   Moseng, D
   Grimstad, O
   Naik, H
   Micheletti, R
   Guilbault, S
   Miller, AP
   Hamzavi, I
   van der Zee, H
   Prens, E
   Kappe, N
   Ardon, C
   Kirby, B
   Hughes, R
   Zouboulis, CC
   Nikolakis, G
   Bechara, FG
   Matusiak, L
   Szepietowski, J
   Glowaczewska, A
   Smith, SD
   Goldfarb, N
   Daveluy, S
   Avgoustou, C
   Giamarellos-Bourboulis, E
   Cohen, S
   Soliman, Y
   Brant, EG
   Akilov, O
   Sayed, C
   Tan, J
   Alavi, A
   Lowes, MA
   Pascual, JC
   Riad, H
   Fisher, S
   Cohen, A
   Paek, SY
   Resnik, B
   Ju, Q
   Wang, LQ
   Strunk, A
AF Garg, Amit
   Neuren, Erica
   Cha, Denny
   Kirby, Joslyn S.
   Ingram, John R.
   Jemec, Gregor B. E.
   Esmann, Solveig
   Thorlacius, Linnea
   Villumsen, Bente
   del Marmol, Veronique
   Nassif, Aude
   Delage, Maia
   Tzellos, Thrasyvoulos
   Moseng, Dagfinn
   Grimstad, Oystein
   Naik, Haley
   Micheletti, Robert
   Guilbault, Sandra
   Miller, Angie Parks
   Hamzavi, Iltefat
   van der Zee, Hessel
   Prens, Errol
   Kappe, Naomi
   Ardon, Christine
   Kirby, Brian
   Hughes, Rosalind
   Zouboulis, Christos C.
   Nikolakis, Georgios
   Bechara, Falk G.
   Matusiak, Lukasz
   Szepietowski, Jacek
   Glowaczewska, Amelia
   Smith, Saxon D.
   Goldfarb, Noah
   Daveluy, Steven
   Avgoustou, Christina
   Giamarellos-Bourboulis, Evangelos
   Cohen, Steven
   Soliman, Yssra
   Brant, Elena Gonzalez
   Akilov, Oleg
   Sayed, Christopher
   Tan, Jerry
   Alavi, Afsaneh
   Lowes, Michelle A.
   Carlos Pascual, Jose
   Riad, Hassan
   Fisher, Shani
   Cohen, Arnon
   Paek, So Yeon
   Resnik, Barry
   Ju, Qiang
   Wang, Lanqi
   Strunk, Andrew
TI Evaluating patients' unmet needs in hidradenitis suppurativa: Results
   from the Global Survey Of Impact and Healthcare Needs (VOICE) Project
SO JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
LA English
DT Article
DE acne inversa; care; comorbid conditions; diagnosis; Global VOICE;
   hidradenitis suppurativa; life impact; pain; patient; symptoms;
   treatment; unmet needs
ID QUALITY-OF-LIFE; INFLAMMATORY-BOWEL-DISEASE; METABOLIC SYNDROME;
   RETROSPECTIVE COHORT; PSYCHOSOCIAL IMPACT; REPORTED OUTCOMES;
   PREVALENCE; DEPRESSION; PAIN; ACNE
AB Background: A needs assessment for patients with hidradenitis suppurativa (HS) will support advancements in multidisciplinary care, treatment, research, advocacy, and philanthropy.
   Objective: To evaluate unmet needs from the perspective of HS patients.
   Methods: Prospective multinational survey of patients between October 2017 and July 2018.
   Results: Before receiving a formal HS diagnosis, 63.7% (n = 827) of patients visited a physician >= 5 times. Mean delay in diagnosis was 10.2 6 8.9 years. Patients experienced flare daily, weekly, or monthly in 23.0%, 29.8%, and 31.1%, respectively. Most (61.4% [n = 798]) rated recent HS-related pain as moderate or higher, and 4.5% described recent pain to be the worst possible. Access to dermatology was rated as difficult by 37.0% (n = 481). Patients reported visiting the emergency department and hospital >= 5 times for symptoms in 18.3% and 12.5%, respectively. An extreme impact on life was reported by 43.3% (n = 563), and 14.5% were disabled due to disease. Patients reported a high frequency of comorbidities, most commonly mood disorders. Patients were dissatisfied with medical or procedural treatments in 45.9% and 34.6%, respectively.
   Limitations: Data were self-reported. Patients with more severe disease may have been selected.
   Conclusion: HS patients have identified several critical unmet needs that will require stakeholder collaboration to meaningfully address.
C1 [Garg, Amit; Neuren, Erica; Cha, Denny; Strunk, Andrew] Donald & Barbara Zucker Sch Med Hofstra Northwell, Dept Dermatol, New Hyde Pk, NY USA.
   [Kirby, Joslyn S.] Penn State Milton S Hershey Med Ctr, Dept Dermatol, Hershey, PA USA.
   [Ingram, John R.] Univ Hosp Wales, Inst Infect & Immun, Cardiff, S Glam, Wales.
   [Jemec, Gregor B. E.; Esmann, Solveig; Thorlacius, Linnea] Zealand Univ Hosp, Dept Dermatol, Roskilde, Denmark.
   [Villumsen, Bente] Danish HS Patients Assoc, Copenhagen, Denmark.
   [del Marmol, Veronique] Univ Libre Bruxelles, Erasme Hosp, Dept Dermatol, Brussels, Belgium.
   [Nassif, Aude; Delage, Maia] Ctr Med, Inst Pasteur, Dept Dermatol, Paris, France.
   [Tzellos, Thrasyvoulos; Moseng, Dagfinn; Grimstad, Oystein] Arctic Univ, Univ Hosp North Norway, Fac Hlth Sci, Inst Clin Med,Dept Dermatol, Tromso, Norway.
   [Naik, Haley] Univ Calif San Francisco, Dept Dermatol, San Francisco, CA USA.
   [Micheletti, Robert] Univ Penn, Dept Dermatol, Perelman Sch Med, Philadelphia, PA 19104 USA.
   [Guilbault, Sandra; Miller, Angie Parks] Hope HS, Detroit, MI USA.
   [Miller, Angie Parks; Hamzavi, Iltefat] Henry Ford Hosp, Dept Dermatol, Detroit, MI 48202 USA.
   [van der Zee, Hessel; Prens, Errol; Ardon, Christine] Erasmus Univ, Med Ctr, Dept Dermatol, Rotterdam, Netherlands.
   [Kappe, Naomi; Kirby, Brian; Hughes, Rosalind] St Vincents Univ Hosp, Dept Dermatol, Dublin, Ireland.
   [Zouboulis, Christos C.; Nikolakis, Georgios] Brandenburg Med Sch Theodor Fontane, Dessau Med Ctr, Dept Dermatol, Dessau, Germany.
   [Zouboulis, Christos C.; Nikolakis, Georgios] Brandenburg Med Sch Theodor Fontane, Dessau Med Ctr, Dept Venereol, Dessau, Germany.
   [Zouboulis, Christos C.; Nikolakis, Georgios] Brandenburg Med Sch Theodor Fontane, Dessau Med Ctr, Dept Allergol, Dessau, Germany.
   [Zouboulis, Christos C.; Nikolakis, Georgios] Brandenburg Med Sch Theodor Fontane, Dessau Med Ctr, Dept Immunol, Dessau, Germany.
   [Bechara, Falk G.] Ruhr Univ, St Josef Hosp, Dept Dermatol Venereol & Allergol, Bochum, Germany.
   [Matusiak, Lukasz; Szepietowski, Jacek; Glowaczewska, Amelia] Wroclaw Med Univ, Dept Dermatol Venereol & Allergol, Wroclaw, Poland.
   [Smith, Saxon D.] Univ Sydney, Sydney Med Sch, Northern Clin Sch, Dept Dermatol, Sydney, NSW, Australia.
   [Goldfarb, Noah] Univ Minnesota, Dept Dermatol, Minneapolis, MN 55455 USA.
   [Daveluy, Steven] Wayne State Univ, Sch Med, Dept Dermatol, Detroit, MI 48201 USA.
   [Avgoustou, Christina; Giamarellos-Bourboulis, Evangelos] Natl & Kapodistrian Univ Athens, Dept Internal Med 4, Sch Med, Athens, Greece.
   [Cohen, Steven; Soliman, Yssra] Albert Einstein Coll Med, Div Dermatol, Bronx, NY 10467 USA.
   [Brant, Elena Gonzalez; Akilov, Oleg] Univ Pittsburgh, Dept Dermatol, Pittsburgh, PA 15260 USA.
   [Sayed, Christopher] Univ N Carolina, Dept Dermatol, Sch Med, Chapel Hill, NC 27515 USA.
   [Tan, Jerry] Western Univ, Dept Med, Windsor Campus, Windsor, ON, Canada.
   [Alavi, Afsaneh] Univ Toronto, Women Coll Hosp, Div Dermatol, Toronto, ON, Canada.
   [Lowes, Michelle A.] Rockefeller Univ, Invest Dermatol Lab, 1230 York Ave, New York, NY 10021 USA.
   [Carlos Pascual, Jose] Alicante Univ, Gen Hosp, Dept Dermatol, Alicante Inst Hlth & Biomed Res ISABIAL FISABIO F, Alicante, Spain.
   [Riad, Hassan] Hamad Med Corp, Al Wakra Hosp, Dept Dermatol, Doha, Qatar.
   [Fisher, Shani] Emek Med Ctr, Dept Dermatol, Afula, Israel.
   [Cohen, Arnon] Gen Management Clalit Hlth Serv, Dept Qual Measures & Res, Chief Phys Off, Tel Aviv, Israel.
   [Paek, So Yeon] Baylor Scott & White Hlth, Dept Dermatol, Dallas, TX USA.
   [Resnik, Barry] Miller Sch Med, Dept Dermatol & Cutaneous Surg, Miami, FL USA.
   [Ju, Qiang; Wang, Lanqi] Shanghai Jiao Tong Univ, Renji Hosp, Sch Med, Dept Dermatol, Shanghai, Peoples R China.
C3 Northwell Health; Pennsylvania Commonwealth System of Higher Education
   (PCSHE); Pennsylvania State University; Penn State Health; Cardiff
   University; Universite Libre de Bruxelles; Pasteur Network; Universite
   Paris Cite; Institut Pasteur Paris; UiT The Arctic University of Tromso;
   University Hospital of North Norway; University of California System;
   University of California San Francisco; University of Pennsylvania;
   Henry Ford Health System; Henry Ford Hospital; Erasmus University
   Rotterdam; Erasmus MC; University College Dublin; Saint Vincent's
   University Hospital; Dessau Medical Center; Dessau Medical Center;
   Dessau Medical Center; Dessau Medical Center; Ruhr University Bochum;
   Wroclaw Medical University; University of Sydney; University of
   Minnesota System; University of Minnesota Twin Cities; Wayne State
   University; Athens Medical School; National & Kapodistrian University of
   Athens; Montefiore Medical Center; Albert Einstein College of Medicine;
   Yeshiva University; Pennsylvania Commonwealth System of Higher Education
   (PCSHE); University of Pittsburgh; University of North Carolina School
   of Medicine; University of North Carolina; University of North Carolina
   Chapel Hill; University of Toronto; Womens College Hospital; Rockefeller
   University; General University Hospital of Alicante; Universidad Miguel
   Hernandez de Elche; Universitat d'Alacant; Instituto de Investigacion
   Sanitaria y Biomedica de Alicante (ISABIAL); Hamad Medical Corporation;
   Emek Medical Center; Baylor Health Care System; Shanghai Jiao Tong
   University
RP Garg, A (corresponding author), Donald & Barbara Zucker Sch Med Hofstra Northwell, 1991 Marcus Ave,Ste 300, New Hyde Pk, NY 11042 USA.
EM amgarg@northwell.edu
RI Grimstad, Ã˜ystein/AAE-7596-2021; Goldfarb, Noah/AAA-3082-2022; פישר,
   שני/KHW-6189-2024; Prof. Dr. Zouboulis, Christos/I-4493-2013;
   Giamarellos-Bourboulis, Evangelos/AAD-7155-2019; Glowaczewska,
   Amelia/CAH-7629-2022; Jemec, Gregor/H-6702-2019; Sayed,
   Christopher/AAC-3343-2020; del marmol, veronique/AAZ-8117-2020; Hamzavi,
   Iltefat/AAW-7320-2021; Akilov, Oleg/I-8753-2019; Garg,
   Amit/JEO-9043-2023; Nikolakis, Georgios/I-5745-2012
OI Garg, Amit/0000-0003-0886-6856; Szepietowski, Jacek/0000-0003-0766-6342;
   Jemec, Gregor/0000-0002-0712-2540; Villumsen, Bente/0000-0002-5176-2166;
   Wang, Lanqi/0000-0002-9211-5600; Thorlacius, Linnea/0000-0002-3734-9607;
   Tzellos, Thrasivoulos/0000-0003-2356-0847; Nikolakis,
   Georgios/0000-0002-0920-9092; Sayed, Christopher/0000-0003-3201-4637;
   Matusiak, Lukasz/0000-0003-2067-4929; Glowaczewska,
   Amelia/0000-0001-7572-0895; Grimstad, Oystein/0000-0001-6783-4534; van
   der zee, HH/0000-0002-2874-7726; Goldfarb, Noah/0000-0003-1070-0652;
   Kappe, Naomi/0000-0003-4614-1477; Paek, So Yeon/0000-0002-1598-5928
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NR 72
TC 212
Z9 212
U1 1
U2 18
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0190-9622
EI 1097-6787
J9 J AM ACAD DERMATOL
JI J. Am. Acad. Dermatol.
PD FEB
PY 2020
VL 82
IS 2
BP 366
EP 376
DI 10.1016/j.jaad.2019.06.1301
PG 11
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA KB3PA
UT WOS:000506410600027
PM 31279015
OA Green Submitted, Green Accepted
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Bello-Chavolla, OY
   Aguilar-Salinas, CA
   Avila-Funes, JA
AF Bello-Chavolla, Omar Yaxmehen
   Aguilar-Salinas, Carlos Alberto
   Avila-Funes, Jose Alberto
TI GERIATRIC SYNDROMES AND NOT CARDIOVASCULAR RISK FACTORS ARE ASSOCIATED
   WITH COGNITIVE IMPAIRMENT AMONG MEXICAN COMMUNITY-DWELLING ELDERLY WITH
   TYPE 2 DIABETES
SO REVISTA DE INVESTIGACION CLINICA-CLINICAL AND TRANSLATIONAL
   INVESTIGATION
LA English
DT Article
DE Geriatric syndrome; Cognitive impairment; Frailty; Urinary incontinence;
   Diabetes
ID METABOLIC SYNDROME; OLDER-ADULTS; URINARY-INCONTINENCE; FRAILTY;
   MELLITUS; DEMENTIA; COHORT; DECLINE; METAANALYSIS; POPULATION
AB Background: The association of cognitive impairment and type 2 diabetes has been consistently shown in several studies, yet its association with geriatric syndromes has not been fully explored. Objective: To study the correlates of cognitive impairment among community-dwelling elderly with type 2 diabetes. Methods: Cross-sectional study of 135 diabetic persons aged 70 years or older participating in the Coyoacan Cohort Study in Mexico City. Baseline data included chronic illnesses, geriatric syndromes, and diabetes-related variables. The lowest quartile in both the Mini-Mental State Examination and the Isaacs Set Test, according to age and schooling, was used to identify participants with cognitive impairment. Multivariate logistic regression analyses were used to identify the correlates of cognitive impairment. Results: Mean age of participants was 77.7 +/- 5.8 years. The prevalence of cognitive impairment was 14.1%. Univariate logistic regression analyses showed that diabetic nephropathy, depression symptoms, falls, and frailty were associated with cognitive impairment. Multivariate logistic regression analyses showed that urinary incontinence and frailty were independently associated with cognitive impairment. Cardiovascular risk factors and diabetes-related variables did not show significant association to cognitive impairment. Conclusions: Geriatric syndromes, but not cardiovascular risk factors, were independently associated with cognitive impairment among diabetic elderlies. Intentional evaluation of these conditions may be important to improve management of the elderly patient with type 2 diabetes and cognitive impairment.
C1 [Bello-Chavolla, Omar Yaxmehen] Univ Nacl Autonoma Mexico, Fac Med, MD PhD Programme, Mexico City, DF, Mexico.
   [Aguilar-Salinas, Carlos Alberto] Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Endocrinol & Metab, Mexico City, DF, Mexico.
   [Avila-Funes, Jose Alberto] Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Geriatr Dept, 15 Col Belisario Dominguez Secc 16, Mexico City 14080, DF, Mexico.
   [Avila-Funes, Jose Alberto] Univ Bordeaux, Bordeaux Populat Hlth Res Ctr, INSERM, UMR 1219, F-33000 Bordeaux, France.
C3 Universidad Nacional Autonoma de Mexico; Instituto Nacional de Ciencias
   Medicas y Nutricion Salvador Zubiran - Mexico; Instituto Nacional de
   Ciencias Medicas y Nutricion Salvador Zubiran - Mexico; Institut
   National de la Sante et de la Recherche Medicale (Inserm); Universite de
   Bordeaux
RP Avila-Funes, JA (corresponding author), Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Geriatr Dept, 15 Col Belisario Dominguez Secc 16, Mexico City 14080, DF, Mexico.
EM avilafunes@live.com.mx
RI AVILA-FUNES, José/T-4210-2019; Salinas, Carlos/HSA-8329-2023;
   Bello-Chavolla, Omar Yaxmehen/AAB-7118-2019
OI AVILA-FUNES, Jose Alberto/0000-0003-0033-5508; Bello-Chavolla, Omar
   Yaxmehen/0000-0003-3093-937X
FU CONACyT, Mexico [SALUD-2006-C01-45075]
FX This study was conducted as part of the Mexican Study of Nutritional and
   Psychosocial Markers of Frailty among Community-Dwelling Elderly. This
   project was funded by CONACyT (grant SALUD-2006-C01-45075), Mexico.
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NR 34
TC 8
Z9 9
U1 0
U2 6
PU INST NACIONAL NUTRICION
PI MEXICO
PA VASCO DE QUIROZA 15, COLONIA SECCION XVI, TLALPAN, MEXICO 14000 D F,
   MEXICO
SN 2385-3956
J9 REV INVEST CLIN
JI Rev. Investig. Clin.
PD MAY-JUN
PY 2017
VL 69
IS 3
BP 166
EP 172
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA EZ6NR
UT WOS:000404835100006
PM 28613287
DA 2025-06-11
ER

PT J
AU Garcia-Serrano, AM
   Skoug, C
   Axling, U
   Korhonen, ER
   Teixeira, C
   Ahrén, IL
   Mukhopadhya, I
   Boteva, N
   Martin, J
   Scott, K
   Gratz, S
   Stenkula, KG
   Holml, C
   Duarte, JMN
AF Garcia-Serrano, A. M.
   Skoug, C.
   Axling, U.
   Korhonen, E. R.
   Teixeira, C.
   Ahren, I. L.
   Mukhopadhya, I.
   Boteva, N.
   Martin, J.
   Scott, K.
   Gratz, S.
   Stenkula, K. G.
   Holml, C.
   Duarte, J. M. N.
TI Butyrate-producing bacteria as probiotic supplement: beneficial effects
   on metabolism and modulation of behaviour in an obesity mouse model
SO BENEFICIAL MICROBES
LA English
DT Article
DE Coprococcus; short-chain fatty acids; cognition; depression; diabetes
ID GUT MICROBIOTA; FAT; HOMEOSTASIS; DIET
AB Obesity is a risk factor for cardio-metabolic and neurological disease. The contribution of gut microbiota to derangements of the gut-brain axis in the context of obesity has been acknowledged, particularly through physiology modulation by short-chain fatty acids (SCFAs). Thus, probiotic interventions and administration of SCFAs have been employed with the purpose of alleviating symptoms in both metabolic and neurological disease. We investigated the effects of four butyrate-producing bacteria from the Lachnospiraceae family on the development of metabolic syndrome and behavioural alterations in a mouse model of diet-induced obesity. Male mice were fed either a high-fat diet (HFD) or an ingredient-matched control diet for 2 months, and bacteria cultures or culture medium were given by gavage to HFD-fed mice every second day. Mice were assessed through a battery of metabolic and behaviour tests, and fluxes through the gut barrier and blood-brain barrier were determined using Dextran-based tracers. One of the administered bacteria from the Coprococcus genus, which produces butyrate and formate, afforded some degree of protection against the development of obesity and its complications. Results from this study, however, are insufficient to support brain health benefits of the bacteria tested. None of the bacteria modulated permeability through the gut or blood-brain barriers. Our results suggest health benefits of a bacteria from Lachnospiraceae family, and encourage further exploration of its use as probiotic.
C1 [Garcia-Serrano, A. M.; Skoug, C.; Korhonen, E. R.; Stenkula, K. G.; Duarte, J. M. N.] Lund Univ, Fac Med, Dept Expt Med Sci, S-22184 Lund, Sweden.
   [Garcia-Serrano, A. M.; Skoug, C.; Duarte, J. M. N.] Lund Univ, Fac Med, Wallenberg Ctr Mol Med, S-22184 Lund, Sweden.
   [Axling, U.; Teixeira, C.; Ahren, I. L.] Probi AB, S-22370 Lund, Sweden.
   [Mukhopadhya, I.] Univ Aberdeen, Inst Med Sci, Aberdeen AB25 2ZD, Scotland.
   [Boteva, N.; Martin, J.; Scott, K.] Univ Aberdeen, Rowett Inst, Aberdeen AB25 2ZD, Scotland.
C3 Lund University; Lund University; University of Aberdeen; University of
   Aberdeen
RP Duarte, JMN (corresponding author), Lund Univ, Fac Med, Dept Expt Med Sci, S-22184 Lund, Sweden.; Duarte, JMN (corresponding author), Lund Univ, Fac Med, Wallenberg Ctr Mol Med, S-22184 Lund, Sweden.
EM joao.duarte@med.lu.se
RI Mukhopadhya, Indrani/K-1113-2019; Garcia-Serrano, Alba/U-5101-2019;
   Skoug, Cecilia/KCY-7907-2024
OI Mukhopadhya, Indrani/0000-0003-2577-518X; Skoug,
   Cecilia/0000-0002-4999-1939
FU Sten K Johnsons Stiftelse, Albert Pahlsson Stiftelse; Swedish Foundation
   for Strategic Research [SM20-0014, IRC15-0067]; Knut and Alice
   Wallenberg foundation; Medical Faculty at Lund University; Lund
   University Diabetes Centre - Swedish Research Council (Strategic
   Research Area EXODIAB) [2009-1039]; Strategic Research Area Multi Park
   (Multidisciplinary Research on Parkinson's Disease)
FX We thank Jenny Rudolfsson for preparation of bacte-ria suspensions given
   to mice, and Tina Ovlund for performing the liver TAGs analysis. This
   work was supported by Sten K Johnsons Stiftelse, Albert Pahlsson
   Stiftelse and the Swedish Foundation for Strategic Research (SM20-0014
   to CH) . The Knut and Alice Wallenberg foundation, and the Medical
   Faculty at Lund University are acknowledged for financial support to
   JMND. The authors acknowledge support from the Lund University Diabetes
   Centre, which is funded by the Swedish Research Council (Strategic
   Research Area EXODIAB, grant 2009-1039) and the Swedish Foundation for
   Strategic Research (grant IRC15-0067) . The Strategic Research Area
   MultiPark (Multidisciplinary Research on Parkinson's Disease) is
   ackowledged for access to mouse behaviour labs. The Rowett Insti-tute
   receives support from the Scottish Government (RESAS) .
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NR 38
TC 1
Z9 1
U1 3
U2 4
PU BRILL
PI LEIDEN
PA PLANTIJNSTRAAT 2, P O BOX 9000, 2300 PA LEIDEN, NETHERLANDS
SN 1876-2883
EI 1876-2891
J9 BENEF MICROBES
JI Benef. Microbes
PY 2025
VL 16
IS 1
BP 109
EP 124
DI 10.1163/18762891-BJA00040
PG 16
WC Microbiology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Microbiology; Nutrition & Dietetics
GA 0GH4K
UT WOS:001446677600006
PM 39322223
DA 2025-06-11
ER

PT J
AU Schwartz, L
   Bourassa, MG
AF Schwartz, L
   Bourassa, MG
TI Evaluation of patients with chest pain and normal coronary angiograms
SO ARCHIVES OF INTERNAL MEDICINE
LA English
DT Review
ID ARTERY DISEASE; SYNDROME-X; ANGINA-PECTORIS; INTRAVASCULAR ULTRASOUND;
   PANIC DISORDER; VARIANT ANGINA; FLOW RESERVE; HYPERTROPHIC
   CARDIOMYOPATHY; MYOCARDIAL-INFARCTION; ERGONOVINE MALEATE
AB Over 1 million coronary angiograms are performed in North America annually, and a significant number are interpreted as normal. In the Coronary Artery Surgery Study Registry of the 1970s, normal angiograms were found in 19% of patients,(1) and the prevalence may not have changed in the current era of more sophisticated noninvasive testing. A recent study found that 19% of patients had no arteriographic evidence of disease.(2) For women selected for angiography, a normal result is found 3 times more frequently than for men.(1,2) Further elucidation of the diagnosis in a patient population of this size is of obvious importance. However, correctly investigating and managing the treatment for such patients can be challenging. On the one hand, a potentially serious, yet manageable condition must not be overlooked. On the other hand, excessive anxiety over a problem that may not exist or may not be serious must not be created. Therefore, the finding of a normal angiogram in a patient with chronic chest pain in whom coronary disease was suspected prior to the procedure must lead to a thorough investigation (Figure 1). The pathophysiologic features, investigation, and treatment of chest pain in these patients are the subject of this review.
C1 Univ Hlth Network, Toronto Gen Hosp, Toronto, ON M5G 2C4, Canada.
   Univ Toronto, Toronto, ON, Canada.
   Univ Montreal, Montreal, PQ, Canada.
   Montreal Heart Inst, Montreal, PQ H1T 1C8, Canada.
C3 University of Toronto; University Health Network Toronto; Toronto
   General Hospital; University of Toronto; Universite de Montreal;
   Universite de Montreal
RP Schwartz, L (corresponding author), Univ Hlth Network, Toronto Gen Hosp, EN 13-204,200 Elizabeth St, Toronto, ON M5G 2C4, Canada.
OI Bourassa, Martial G./0000-0002-4439-8650
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NR 78
TC 26
Z9 28
U1 0
U2 0
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 515 N STATE ST, CHICAGO, IL 60610 USA
SN 0003-9926
J9 ARCH INTERN MED
JI Arch. Intern. Med.
PD AUG 13
PY 2001
VL 161
IS 15
BP 1825
EP 1833
DI 10.1001/archinte.161.15.1825
PG 9
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 459DZ
UT WOS:000170236900003
PM 11493123
DA 2025-06-11
ER

PT J
AU Esposito, K
   Maiorino, MI
   Bellastella, G
   Giugliano, F
   Romano, M
   Giugliano, D
AF Esposito, K.
   Maiorino, M. I.
   Bellastella, G.
   Giugliano, F.
   Romano, M.
   Giugliano, D.
TI Determinants of female sexual dysfunction in type 2 diabetes
SO INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH
LA English
DT Article
DE epidemiology; FSD; type 2 diabetes; glycemic control
ID FUNCTION INDEX FSFI; ERECTILE DYSFUNCTION; RISK-FACTORS; WOMEN;
   PREVALENCE; HYPERGLYCEMIA; OBESITY
AB Studies assessing sexual dysfunction in type 2 diabetic women are scanty. This study was designed to evaluate the prevalence and correlates of female sexual function in a quite large population of diabetic women. A total of 595 women with type 2 diabetes completed a questionnaire of self-report measures of sexual dysfunction and were analyzed in this study. Their age was 57.9 +/- 6.9 (mean and s.d.), duration of diabetes was 5.2 +/- 1.5 years and mean hemoglobin A1c (HbA1c) level was 8.3 +/- 1.3%. Female sexual dysfunction (FSD) was assessed by the Female Sexual Function Index instrument with a cut-off score of 23. The overall prevalence of FSD among the diabetic women was 53.4%, significantly higher in menopausal women (63.9%), as compared with nonmenopausal women (41.0%, P<0.001). There was no association between HbA1c, duration of diabetes, hypertension, or cigarette smoking status and FSD; on the contrary, age, metabolic syndrome and atherogenic dyslipidemia were significantly associated with FSD. Both depression and marital status were independent predictors of FSD, while physical activity was protective. Further studies are needed to elucidate in full the mechanisms underlying the evident differences between male and female sexual function. In the meantime, evaluation of female sexuality should become a routine evaluation in women with type 2 diabetes, such as other diabetic complications. International Journal of Impotence Research (2010) 22, 179-184; doi: 10.1038/ijir.2010.6; published online 8 April 2010
C1 [Esposito, K.; Maiorino, M. I.; Bellastella, G.; Giugliano, F.; Romano, M.; Giugliano, D.] Univ Naples 2, Dept Geriatr & Metab Dis, I-80138 Naples, Italy.
   [Esposito, K.; Giugliano, D.] Italian Soc Endocrinol, Artemis Grp Female Hlth, Naples, Italy.
C3 Universita della Campania Vanvitelli
RP Esposito, K (corresponding author), Univ Naples 2, Dept Geriatr & Metab Dis, I-80138 Naples, Italy.
EM katherine.esposito@unina2.it
RI Esposito, Katherine/AHE-2564-2022; Maiorino, Maria Ida/AHE-9986-2022;
   Maiorino, Maria Ida/K-3264-2016
OI Maiorino, Maria Ida/0000-0003-4659-7546; Giugliano,
   Dario/0000-0002-9377-873X
CR Abu Ali RM, 2008, DIABETES CARE, V31, P1580, DOI 10.2337/dc08-0081
   [Anonymous], GUID DAT PROC AN INT
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NR 34
TC 119
Z9 128
U1 0
U2 10
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0955-9930
EI 1476-5489
J9 INT J IMPOT RES
JI Int. J. Impot. Res.
PD MAY-JUN
PY 2010
VL 22
IS 3
BP 179
EP 184
DI 10.1038/ijir.2010.6
PG 6
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 595BZ
UT WOS:000277587000003
PM 20376056
DA 2025-06-11
ER

PT J
AU Kipnes, MS
   Hollander, P
   Fujioka, K
   Gantz, I
   Seck, T
   Erondu, N
   Shentu, Y
   Lu, K
   Suryawanshi, S
   Chou, M
   Johnson-Levonas, AO
   Heymsfield, SB
   Shapiro, D
   Kaufman, KD
   Amatruda, JM
AF Kipnes, M. S.
   Hollander, P.
   Fujioka, K.
   Gantz, I.
   Seck, T.
   Erondu, N.
   Shentu, Y.
   Lu, K.
   Suryawanshi, S.
   Chou, M.
   Johnson-Levonas, A. O.
   Heymsfield, S. B.
   Shapiro, D.
   Kaufman, K. D.
   Amatruda, J. M.
TI A one-year study to assess the safety and efficacy of the CB1R inverse
   agonist taranabant in overweight and obese patients with type 2 diabetes
SO DIABETES OBESITY & METABOLISM
LA English
DT Article
DE cannabinoid-1 receptor; diabetes; endocannabinoid; obesity; randomized
   clinical trial
ID CANNABINOID-1 RECEPTOR BLOCKER; CARDIOMETABOLIC RISK-FACTORS; LIFE-STYLE
   INTERVENTION; QUALITY-OF-LIFE; WEIGHT-MANAGEMENT; DOUBLE-BLIND;
   BODY-WEIGHT; RIMONABANT; ORLISTAT; DEPRESSION
AB Aim: To evaluate the efficacy and safety of taranabant in overweight and obese patients with type 2 diabetes mellitus (T2DM).
   Methods: This was a multicenter, double-blind, randomized, placebo-controlled study in overweight and obese patients with T2DM (ages >= 18 and < 75 years) with a BMI >= 27 kg/m2 and < 43 kg/m2 and HbA1c >= 7.0 and < 10.0%, who were either not on an antihyperglycaemic agent or on a stable dose of metformin (>= 1500 mg/day). After a 2-week placebo run-in, patients were randomized to placebo (N = 156) or taranabant 0.5-mg (N = 155), 1-mg (N = 157), or 2-mg (N = 155) once daily for 52 weeks. Primary efficacy endpoints were changes from baseline in body weight (BW) and HbA1c at Week 36, with results at Week 52 being key secondary endpoints.
   Results: In the all-patients-treated population, using a last-observation-carried-forward analysis, reductions in BW were -2.5, -3.7, -4.5 and -5.1 kg at Week 36 and -2.4, -4.0, -4.6 and -5.3 kg at Week 52 in the placebo, 0.5-, 1- and 2-mg groups, respectively (all doses significant vs. placebo at both time points). The proportion of patients who lost >= 5 and >= 10% of their baseline BW was significantly greater in the 1- and 2-mg groups vs. placebo at Week 36 and all taranabant groups vs. placebo at Week 52. Reductions in HbA1c were -0.40, -0.47, -0.68 and -0.71% at Week 36 and -0.30, -0.43, -0.65 and -0.64% at Week 52, in the placebo, 0.5-, 1- and 2-mg groups, respectively (1- and 2-mg doses significant vs. placebo at both time points). After 52 weeks, the incidences of adverse experiences classified in the gastrointestinal (diarrhoea, nausea, vomiting), nervous system-related (dizziness, sensory-related), and psychiatric (irritability, depression-related) organ systems were numerically higher or statistically significantly higher in all taranabant groups compared with the placebo group.
   Conclusions: After 36 and 52 weeks, treatment with taranabant at the 1- and 2-mg doses led to clinically significant weight loss and improvement in glycaemic parameters in overweight and obese patients with T2DM that was associated with dose-related increases in adverse experiences. Based on these data and data from other Phase III clinical studies, it was determined that the overall safety and efficacy profile of taranabant did not support further development for the treatment of obesity.
C1 [Kipnes, M. S.] Diabet & Glandular Dis Res, San Antonio, TX 78229 USA.
   [Hollander, P.] Baylor Med Ctr, Dallas, TX USA.
   [Fujioka, K.] Scripps Clin, Dept Nutr, La Jolla, CA 92037 USA.
   [Fujioka, K.] Scripps Clin, Metab Res Ctr, La Jolla, CA 92037 USA.
   [Gantz, I.; Seck, T.; Erondu, N.; Shentu, Y.; Lu, K.; Suryawanshi, S.; Chou, M.; Johnson-Levonas, A. O.; Heymsfield, S. B.; Shapiro, D.; Kaufman, K. D.; Amatruda, J. M.] Merck & Co Inc, Merck Res Labs, Rahway, NJ 07065 USA.
C3 Scripps Research Institute; Scripps Research Institute; Merck & Company;
   Merck & Company USA
RP Kipnes, MS (corresponding author), Diabet & Glandular Dis Res, 5107 Med Dr, San Antonio, TX 78229 USA.
EM mkipnes@dgdclinic.com
RI Heymsfield, Steven/N-1968-2017
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NR 54
TC 36
Z9 41
U1 0
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1462-8902
EI 1463-1326
J9 DIABETES OBES METAB
JI Diabetes Obes. Metab.
PD JUN
PY 2010
VL 12
IS 6
BP 517
EP 531
DI 10.1111/j.1463-1326.2009.01188.x
PG 15
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 586XK
UT WOS:000276948400006
PM 20518807
DA 2025-06-11
ER

PT J
AU Kawashima, M
   Sano, K
   Takechi, S
   Tsubota, K
AF Kawashima, Motoko
   Sano, Kokoro
   Takechi, Sayuri
   Tsubota, Kazuo
TI Impact of lifestyle intervention on dry eye disease in office workers: a
   randomized controlled trial
SO JOURNAL OF OCCUPATIONAL HEALTH
LA English
DT Article
DE Dry eye; Lifestyle intervention; Office worker; Randomized controlled
   trial
ID VISUAL-DISPLAY TERMINALS; SUBJECTIVE HAPPINESS; METABOLIC SYNDROME;
   ASSOCIATION; DEPRESSION; PREVALENCE; VALIDATION; USERS
AB Objectives: To evaluate the effects of a 2-month lifestyle intervention for dry eye disease in office workers. Methods: Prospective interventional study (randomized controlled study). Forty-one middle-aged Japanese office workers (men, 22; women, 19; 39.2 +/- 8.0 years) with definite and probable dry eye disease were enrolled and randomized to an intervention group (n = 22) and a control group (n = 19). The intervention aimed at modifying diet, increasing physical activity, and encouraging positive thinking. The primary outcome was change in dry eye disease diagnoses. Secondary outcome was change in disease parameters, including dry eye symptoms, as assessed using the Dry Eye-Related Quality of Life Score, corneal and conjunctival staining scores, tear break-up time, and Schirmer test results. Results: A total of 36 participants (intervention group, 17; control group, 19) completed the study. The number of definite dry eye disease diagnoses decreased from four to none (p = .05), and the dry eye symptom score showed a significant decrease in the intervention group (p = .03). In contrast, the corneal and conjunctival staining scores, tear break-up time, and Schirmer test results did not differ significantly between groups. Conclusions: The 2-month lifestyle intervention employed in this study improved dry eye disease status among office workers, with a considerable decrease in subjective symptoms. Lifestyle intervention may be a promising management option for dry eye disease, although further investigation of long-term effects are required.
C1 [Kawashima, Motoko; Sano, Kokoro; Tsubota, Kazuo] Keio Univ, Dept Ophthalmol, Sch Med, Tokyo, Japan.
   [Takechi, Sayuri] Keio Univ, Dept Neuropsychiat, Sch Med, Tokyo, Japan.
C3 Keio University; Keio University
RP Kawashima, M (corresponding author), Keio Univ, Dept Ophthalmol, Sch Med, Shinjuku Ku, 35 Shinanomachi, Tokyo 1608582, Japan.
EM motoko-k@a3.keio.jp
RI Tsubota, Kazuo/M-1915-2013
OI Tsubota, Kazuo/0000-0002-8874-7111
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NR 27
TC 36
Z9 36
U1 2
U2 14
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1341-9145
EI 1348-9585
J9 J OCCUP HEALTH
JI J. Occup. Health
PD JUL
PY 2018
VL 60
IS 4
BP 281
EP 288
DI 10.1539/joh.2017-0191-OA
PG 8
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA GO3SV
UT WOS:000439916400002
PM 29618677
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Li, G
   Chen, C
   Laing, SD
   Ballard, C
   Biju, KC
   Reddick, RL
   Clark, RA
   Li, S
AF Li, G.
   Chen, C.
   Laing, S. D.
   Ballard, C.
   Biju, K. C.
   Reddick, R. L.
   Clark, R. A.
   Li, S.
TI Hematopoietic knockdown of PPARδ reduces atherosclerosis in LDLR-/- mice
SO GENE THERAPY
LA English
DT Article
ID ACTIVATED-RECEPTOR-DELTA; PREVENTS ENDOTHELIAL DYSFUNCTION; NF-KAPPA-B;
   METABOLIC SYNDROME; MOLECULAR-MECHANISMS; GENE-THERAPY; BETA/DELTA;
   EXPRESSION; DISEASE; INFLAMMATION
AB PPAR(delta) (peroxisome proliferator-activated receptor delta) mediates inflammation in response to lipid accumulation. Systemic administration of a PPAR(delta) agonist can ameliorate atherosclerosis. Paradoxically, genetic deletion of PPAR(delta) in hematopoietic cells led to a reduction of atherosclerosis in murine models, suggesting that downregulation of PPAR(delta) expression in these cells may mitigate atherogenesis. To advance this finding forward to potential clinical translation through hematopoietic stem cell transplantation-based gene therapy, we employed a microRNA (miRNA) approach to knock down PPAR(delta) expression in bone marrow cells followed by transplantation of the cells into LDLR-/- mice. We found that knockdown of PPARd expression in the hematopoietic system caused a dramatic reduction in aortic atherosclerotic lesions. In macrophages, a key component in atherogenesis, knockdown of PPAR(delta) led to decreased expression of multiple pro-inflammatory factors, including monocyte chemoattractant protein-1 (MCP-1), interleukin (IL)-1 beta and IL-6. Expression of CCR2, a receptor for MCP-1, was also decreased. The downregulation of pro-inflammatory factors is consistent with significant reduction of macrophage presence in the lesions, which may also be attributable to elevation of ABCA1 (ATP-binding cassette, subfamily A, member 1) and depression of adipocyte differentiate-related protein. Furthermore, the abundance of both MCP-1 and matrix metalloproteinase-9 proteins was reduced in plaque areas. Our results demonstrate that miRNA-mediated PPAR delta knockdown in hematopoietic cells is able to ameliorate atherosclerosis.
C1 [Li, G.; Chen, C.; Laing, S. D.; Ballard, C.; Biju, K. C.; Clark, R. A.; Li, S.] Univ Texas Hlth Sci Ctr San Antonio, Dept Med, 7703 Floyd Curl Dr, San Antonio, TX 78229 USA.
   [Li, G.; Chen, C.; Laing, S. D.; Ballard, C.; Biju, K. C.; Clark, R. A.; Li, S.] South Texas Vet Hlth Care Syst, Audie L Murphy Div, San Antonio, TX USA.
   [Reddick, R. L.] Univ Texas Hlth Sci Ctr San Antonio, Dept Pathol, 7703 Floyd Curl Dr, San Antonio, TX 78229 USA.
   [Li, S.] Univ Texas Hlth Sci Ctr San Antonio, Dept Pharmacol, 7703 Floyd Curl Dr, San Antonio, TX 78229 USA.
C3 University of Texas System; University of Texas Health Science Center at
   San Antonio; US Department of Veterans Affairs; Veterans Health
   Administration (VHA); Audie L. Murphy Memorial Veterans Hospital;
   University of Texas System; University of Texas Health Science Center at
   San Antonio; University of Texas System; University of Texas Health
   Science Center at San Antonio
RP Li, S (corresponding author), Univ Texas Hlth Sci Ctr San Antonio, Dept Med, 7703 Floyd Curl Dr, San Antonio, TX 78229 USA.; Li, S (corresponding author), South Texas Vet Hlth Care Syst, Audie L Murphy Div, San Antonio, TX USA.; Li, S (corresponding author), Univ Texas Hlth Sci Ctr San Antonio, Dept Pharmacol, 7703 Floyd Curl Dr, San Antonio, TX 78229 USA.
EM lis1@uthscsa.edu
OI Chandu, Biju/0000-0002-8409-6374; Clark, Robert/0000-0002-4892-3619
FU Research Division of the Department of Veterans Affairs; William and
   Ella Owens Medical Research Foundation; Clinical and Translational
   Science Award from the National Institutes of Health [TR001120]; US
   Veterans Health Administration
FX We thank Xiaoling Xue and Qiong Zhang for excellent laboratory
   assistance. This study was supported by a Merit Review grant from the
   Research Division of the Department of Veterans Affairs and by a grant
   from William and Ella Owens Medical Research Foundation awarded to SL.
   RAC is supported by Clinical and Translational Science Award TR001120
   from the National Institutes of Health. This study was supported by a
   grant from the US Veterans Health Administration.
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NR 52
TC 17
Z9 19
U1 0
U2 3
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0969-7128
EI 1476-5462
J9 GENE THER
JI Gene Ther.
PD JAN
PY 2016
VL 23
IS 1
BP 78
EP 85
DI 10.1038/gt.2015.78
PG 8
WC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
   Genetics & Heredity; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
   Genetics & Heredity; Research & Experimental Medicine
GA DC9ND
UT WOS:000369547400009
PM 26204499
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Ahmed, M
   El-Bakly, WM
   Zaki, AM
   abd Alzez, LF
   El Serafi, O
AF Ahmed, Mai
   El-Bakly, Wesam M.
   Zaki, Ahmed M.
   abd Alzez, Lobna F.
   El Serafi, Osama
TI Bupropion effects on high-fat diet-induced steatohepatitis and
   endothelial dysfunction in rats: role of tumour necrosis factor-alpha
SO JOURNAL OF PHARMACY AND PHARMACOLOGY
LA English
DT Article
DE bupropion; atherosclerosis; TNF-alpha; insulin resistance; non-alcoholic
   steatohepatitis (NASH)
ID INSULIN-RESISTANCE; TNF-ALPHA; NONALCOHOLIC STEATOHEPATITIS; HEPATIC
   INFLAMMATION; METABOLIC SYNDROME; LIVER-DISEASE; RISK-FACTORS; MODEL;
   MECHANISMS; GLUCOSE
AB Objectives
   This study aimed to elucidate the effect of bupropion (BUP) on high-fat diet (HFD)-treated rats that is to say the action of BUP on diabetes and hyperlipidemia with its consequences on liver and endothelial function.
   Methods
   Male Wistar rats were fed HFD or normal chow for 15 weeks then given either BUP (50 mg/kg) or distilled water by gavage for 4 weeks. The effect of BUP on diabetes, hyperlipidemia, hepatic and vascular functions as well as tumour necrosis factor-alpha (TNF)-alpha were assessed. The intima-media thickness of the aorta was evaluated.
   Key findings
   BUP significantly decreased serum lipid, liver enzyme, homeostasis model assessment for insulin resistance (HOMA-IR), serum TNF-alpha and the impaired glucose tolerance. Liver from rats with non-alcoholic steatohepatitis (NASH) demonstrated significant higher TNF-alpha level, inflammatory cell infiltration, ballooning and steatosis which significantly ameliorated by BUP treatment. Neither intima/media ratio nor vascular reactivity to acetylcholine is improved by BUP treatment.
   Conclusions
   NASH induced by a HFD was associated with hyperlipidemia, insulin resistance, endothelial dysfunction and increase in liver TNF-alpha. All of these may contribute to the pathogenesis of NASH. BUP has potential role in improving metabolic and hepatic function with negative vascular effect. Since BUP is a well-known antidepressant, it will be a candidate drug in treatment of depression in hepatic diseased or metabolic disturbed patients.
C1 [Ahmed, Mai; El-Bakly, Wesam M.; abd Alzez, Lobna F.; El Serafi, Osama] Ain Shams Univ, Dept Pharmacol, Cairo, Egypt.
   [Ahmed, Mai; El-Bakly, Wesam M.; Zaki, Ahmed M.; abd Alzez, Lobna F.; El Serafi, Osama] Ain Shams Univ, Fac Med, Cairo, Egypt.
   [Zaki, Ahmed M.] Ain Shams Univ, Dept Pathol, Cairo, Egypt.
C3 Egyptian Knowledge Bank (EKB); Ain Shams University; Egyptian Knowledge
   Bank (EKB); Ain Shams University; Egyptian Knowledge Bank (EKB); Ain
   Shams University
RP El-Bakly, WM (corresponding author), Ain Shams Univ, Dept Pharmacol, Fac Pharm, Cairo, Egypt.
EM w_bakly@yahoo.com
RI Bakly, wesam/Q-1398-2015; Ahmed, Mai/KRQ-4237-2024
OI Badr, Ahmed/0000-0001-9758-4708
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NR 40
TC 9
Z9 12
U1 0
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-3573
EI 2042-7158
J9 J PHARM PHARMACOL
JI J. Pharm. Pharmacol.
PD JUN
PY 2014
VL 66
IS 6
BP 793
EP 801
DI 10.1111/jphp.12213
PG 9
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA AG6BO
UT WOS:000335503600005
PM 24471744
OA Bronze
DA 2025-06-11
ER

PT J
AU Hill, J
   Peer, N
   Jonathan, D
   Mayige, M
   Sobngwi, E
   Kengne, AP
AF Hill, Jillian
   Peer, Nasheeta
   Jonathan, Deborah
   Mayige, Mary
   Sobngwi, Eugene
   Kengne, Andre Pascal
TI Findings from Community-Based Screenings for Type 2 Diabetes Mellitus in
   at Risk Communities in Cape Town, South Africa: A Pilot Study
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Article
DE diabetes risk; community screening; cardiovascular disease;
   hypertension; dyslipidemia
ID LIFE-STYLE; METABOLIC SYNDROME; GLUCOSE-TOLERANCE; PRIMARY-CARE;
   PREVENTION; BELLVILLE; ANXIETY; PEOPLE; WORLD
AB Completed and ongoing implementation activities globally advocate for community-based approaches to improve strategies for type 2 diabetes prevention. However, little is known about such strategies in the African region where there are higher relative increases in diabetes prevalence. We reported findings from the first 8-month pilot phase of the South African diabetes prevention program. The study was conducted across eight townships (four black and four mixed-ancestry communities) in Cape Town, South Africa, between August 2017 and March 2018. Participants were recruited using both random and self-selected sampling techniques because the former approach proved to be ineffective; <10% of randomly selected individuals consented to participate. Non-laboratory-based diabetes risk screening, using the African diabetes risk score, and based on targeted population specific cut-offs, identified potentially high-risk adults in the community. This was followed by an oral glucose tolerance test (OGTT) to confirm prevalent pre-diabetes. Among the 853 adults without prior diabetes who were screened in the community, 354 (43.4%) were classified as high risk, and 316 presented for further screening. On OGTT, 13.1% had dysglycemia, including 10% with screen-detected diabetes and 67.9% with glycated haemoglobin (HbA1c)-defined high risk. Participants with pre-diabetes (n = 208) had high levels of common cardiovascular risk factors, i.e., obesity (73.7%), elevated total cholesterol (51.9%), and hypertension (29.4%). Self-referral is likely an efficient method for selecting participants for community-based diabetes risk screening in Africa. Post-screening management of individuals with pre-diabetes must include attention to co-morbid cardiovascular risk factors.
C1 [Hill, Jillian; Peer, Nasheeta; Jonathan, Deborah; Kengne, Andre Pascal] South African Med Res Council SAMRC, Noncommunicable Dis Res Unit, ZA-7505 Cape Town, South Africa.
   [Mayige, Mary] Natl Inst Med Res, Dar Es Salaam 11000, Tanzania.
   [Sobngwi, Eugene] Univ Yaounde, Dept Med, Yaounde 00000, Cameroon.
C3 University of Yaounde I
RP Hill, J (corresponding author), South African Med Res Council SAMRC, Noncommunicable Dis Res Unit, ZA-7505 Cape Town, South Africa.
EM jillian.hill@mrc.ac.za; nasheeta.peer@mrc.ac.za;
   Deborah.Jonathan@mrc.ac.za; maryma13@yahoo.com; sobngwieugene@yahoo.fr;
   andre.kengne@mrc.ac.za
RI Kengne, Andre/ABB-3696-2020; Hill, Jillian/AGU-3305-2022; Mayige,
   Mary/L-5342-2016
OI Mayige, Mary/0000-0003-4861-7870; Peer, Nasheeta/0000-0003-2131-8344;
   Kengne, Andre Pascal/0000-0002-5183-131X; Sobngwi,
   Eugene/0000-0001-5457-6572
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NR 38
TC 12
Z9 11
U1 0
U2 2
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD APR
PY 2020
VL 17
IS 8
AR 2876
DI 10.3390/ijerph17082876
PG 15
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA LR5OL
UT WOS:000535744100261
PM 32326364
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Harley, KG
   Schall, RA
   Chevrier, J
   Tyler, K
   Aguirre, H
   Bradman, A
   Holland, NT
   Lustig, RH
   Calafat, AM
   Eskenazi, B
AF Harley, Kim G.
   Schall, Raul Aguilar
   Chevrier, Jonathan
   Tyler, Kristin
   Aguirre, Helen
   Bradman, Asa
   Holland, Nina T.
   Lustig, Robert H.
   Calafat, Antonia M.
   Eskenazi, Brenda
TI Prenatal and Postnatal Bisphenol A Exposure and Body Mass Index in
   Childhood in the CHAMACOS Cohort
SO ENVIRONMENTAL HEALTH PERSPECTIVES
LA English
DT Article
DE bisphenol A; BMI; CHAMACOS; children; obesity
ID PERINATAL EXPOSURE; URINARY CONCENTRATIONS; TEMPORAL VARIABILITY;
   METABOLIC SYNDROME; NEONATAL EXPOSURE; OBESITY; PREDICTORS; CHILDREN;
   PHENOLS; ANXIETY
AB BACKGROUND: Bisphenol A (BPA), a widely used endocrine-disrupting chemical, has been associated with increased body weight and fat deposition in rodents.
   OBJECTIVES: We examined whether prenatal and postnatal urinary BPA concentrations were associated with body mass index (BMI), waist circumference, percent body fat, and obesity in 9-year-old children (n = 311) in the CHAMACOS longitudinal cohort study.
   METHODS: BPA was measured in spot urine samples collected from mothers twice during pregnancy and from children at 5 and 9 years of age.
   RESULTS: Prenatal urinary BPA concentrations were associated with decreased BMI at 9 years of age in girls but not boys. Among girls, being in the highest tertile of prenatal BPA concentrations was associated with decreased BMI z-score (beta = -0.47, 95% CI: -0.87, -0.07) and percent body fat (beta = -4.36, 95% CI: -8.37, -0.34) and decreased odds of overweight/obesity [odds ratio (OR) = 0.37, 95% CI: 0.16, 0.91] compared with girls in the lowest tertile. These findings were strongest in prepubertal girls. Urinary BPA concentrations at 5 years of age were not associated with any anthropometric parameters at 5 or 9 years, but BPA concentrations at 9 years were positively associated with BMI, waist circumference, fat mass, and overweight/obesity at 9 years in boys and girls.
   CONCLUSIONS: Consistent with other cross-sectional studies, higher urinary BPA concentrations at 9 years of age were associated with increased adiposity at 9 years. However, increasing BPA concentrations in mothers during pregnancy were associated with decreased BMI, body fat, and overweight/obesity among their daughters at 9 years of age.
C1 [Harley, Kim G.; Schall, Raul Aguilar; Chevrier, Jonathan; Tyler, Kristin; Aguirre, Helen; Bradman, Asa; Holland, Nina T.; Eskenazi, Brenda] Univ Calif Berkeley, Ctr Environm Res & Childrens Hlth, Sch Publ Hlth, Berkeley, CA 94704 USA.
   [Lustig, Robert H.] Univ Calif San Francisco, Div Endocrinol, San Francisco, CA 94143 USA.
   [Calafat, Antonia M.] Ctr Dis Control & Prevent, Div Sci Lab, Natl Ctr Environm Hlth, Atlanta, GA USA.
C3 University of California System; University of California Berkeley;
   University of California System; University of California San Francisco;
   Centers for Disease Control & Prevention - USA
RP Harley, KG (corresponding author), Univ Calif Berkeley, Ctr Environm Res & Childrens Hlth, Sch Publ Hlth, 1995 Univ Ave,Suite 265, Berkeley, CA 94704 USA.
EM kharley@berkeley.edu
RI Duran, Bonnie/A-3029-2009; Calafat, Antonia/N-1183-2019; Lustig,
   Robert/O-9380-2019; Harley, Kim/NDT-0453-2025
OI Chevrier, Jonathan/0000-0002-5355-0765
FU National Institute of Environmental Health Sciences [1RC2 ES018792, PO1
   ES009605]; U.S. Environmental Protection Agency [R82670901, RD83171001,
   RD83451301]
FX This work was supported by grants 1RC2 ES018792 and PO1 ES009605 from
   the National Institute of Environmental Health Sciences and grants
   R82670901, RD83171001, and RD83451301 from the U.S. Environmental
   Protection Agency.
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NR 45
TC 194
Z9 211
U1 0
U2 77
PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE
PI RES TRIANGLE PK
PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233,
   RES TRIANGLE PK, NC 27709-2233 USA
SN 0091-6765
EI 1552-9924
J9 ENVIRON HEALTH PERSP
JI Environ. Health Perspect.
PD APR
PY 2013
VL 121
IS 4
BP 514
EP 520
DI 10.1289/ehp.1205548
PG 7
WC Environmental Sciences; Public, Environmental & Occupational Health;
   Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health; Toxicology
GA 208UM
UT WOS:000323706100038
PM 23416456
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Khan, UI
   Qureshi, A
   Lal, K
   Ali, S
   Barkatali, A
   Nayani, S
AF Khan, Unab I.
   Qureshi, Asra
   Lal, Karishma
   Ali, Shehreen
   Barkatali, Arshnoor
   Nayani, Shamim
TI Implementation and evaluation of Employee Health and Wellness Program
   using RE-AIM framework
SO INTERNATIONAL JOURNAL OF WORKPLACE HEALTH MANAGEMENT
LA English
DT Article
DE Employee Health and Wellness Program; Low-middle income countries;
   Preventive care model; RE-AIM framework; Framingham risk score (FRS);
   Metabolic syndrome (MetS)
ID INTERVENTIONS; DISEASES
AB Purpose The study describes the design, implementation and evaluation of an employer-sponsored health screening program - Employee Health and Wellness Program (EHWP) - in an academic healthcare system in Pakistan. Design/methodology/approach One year after implementation, RE-AIM (reach, effectiveness, adoption, implementation and maintenance) framework was used to evaluate and report participant- and organizational-level indicators of success. Findings Of the 5,286 invited employees, 4,523 (86%) completed blood work and 1809 (34%) completed health risk assessment (reach). Of the 915 (51%) who required referrals, 3% were referred for new diagnoses of diabetes, hepatitis C or severe anemia; 63% for elevated 10-year risk of cardiometabolic diseases (cardiovascular disease and diabetes); and 25% for counseling for depression, obesity or smoking cessation (effectiveness). Employees' barriers to enrollment were explored (adoption). While institutional costs were considered nominal (USD 20/employee), organizational barriers were identified (implementation). Finally, 97% of users reported interest in enrollment if EHWP was offered again (maintenance). Originality/value In a country with minimal focus on adult preventive care, the study reports the impact of an employer-offered wellness program that identified new risk factors and offered a referral for ongoing care. Employees reported a positive experience and were willing to re-enroll. Using the RE-AIM framework, the study has defined indicators in the real-world setting that can be used effectively by other institutions to start such a program.
C1 [Khan, Unab I.; Qureshi, Asra; Lal, Karishma] Aga Khan Univ, Dept Family Med, Karachi, Pakistan.
   [Ali, Shehreen; Barkatali, Arshnoor] Aga Khan Univ Hosp, Employee Hlth, Karachi, Pakistan.
   [Nayani, Shamim] Aga Khan Univ, Dept Human Resources, Karachi, Pakistan.
C3 Aga Khan University; Aga Khan University; Aga Khan University
RP Khan, UI (corresponding author), Aga Khan Univ, Dept Family Med, Karachi, Pakistan.
EM unab.khan@aku.edu; asra.qureshi@aku.edu; karishma.kanhya@gmail.com;
   shehreen.ali@aku.edu; arshnoor.barkatali@aku.edu; shamim.nayani@aku.edu
OI Lal, Karishma/0000-0001-7561-9025; Khan, Unab/0000-0002-7002-1726; Ali,
   Shehreen/0000-0002-3599-6405
CR Addley K, 2014, HEALTH EDUC RES, V29, P247, DOI 10.1093/her/cyt113
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NR 18
TC 2
Z9 2
U1 0
U2 3
PU EMERALD GROUP PUBLISHING LTD
PI BINGLEY
PA HOWARD HOUSE, WAGON LANE, BINGLEY BD16 1WA, W YORKSHIRE, ENGLAND
SN 1753-8351
EI 1753-836X
J9 INT J WORKPLACE HEAL
JI Int. J. Workplace Health Manag.
PD JAN 18
PY 2022
VL 15
IS 1
BP 87
EP 98
DI 10.1108/IJWHM-04-2021-0081
EA DEC 2021
PG 12
WC Public, Environmental & Occupational Health
WE Emerging Sources Citation Index (ESCI)
SC Public, Environmental & Occupational Health
GA YN4TY
UT WOS:000727978600001
DA 2025-06-11
ER

PT J
AU Youngstedt, SD
   Kline, CE
   Zielinski, MR
   Kripke, DF
   Devlin, TM
   Bogan, RK
   Wilcox, S
   Hardin, JW
AF Youngstedt, Shawn D.
   Kline, Christopher E.
   Zielinski, Mark R.
   Kripke, Daniel F.
   Devlin, Tina M.
   Bogan, Richard K.
   Wilcox, Sara
   Hardin, James W.
TI Tolerance of Chronic 90-Minute Time-In-Bed Restriction in Older Long
   Sleepers
SO SLEEP
LA English
DT Article
DE Long sleep; time-in-bed restriction; randomized controlled trial
ID VIGILANCE PERFORMANCE; METABOLIC SYNDROME; DURATION; MORTALITY;
   SLEEPINESS; RISK; FRAGMENTATION; INSOMNIA; ASSOCIATION; DISEASE
AB Study Objectives: To examine the influence of chronic time-in-bed (TIB) restriction on selected health-related outcome variables in older long sleepers.
   Design: Randomized, controlled trial.
   Setting: Home-based.
   Participants: Forty-two older adults (aged 50-70 y) who reported sleeping at least 8.5 hours. Following extensive screening, participants were assessed for 10 weeks.
   Intervention: During a two-week baseline, participants followed their usual sleep-wake habits. Participants were then randomized to one of two eight-week treatments: (1) TIB restriction, in which participants were asked to follow a fixed sleep schedule with a TIB of 90 minutes less than recorded during baseline or (2) a control treatment, which involved following a fixed sleep schedule (consistent with average baseline) but no TIB restriction.
   Measurements and Results: Continuous wrist actigraphic sleep estimation indicated that TIB restriction elicited significant reductions in TIB and total sleep time compared with the control treatment and significant (albeit modest) improvements in sleep efficiency and sleep latency. However, compared with the control treatment, TIB restriction elicited no significant change in depression, sleepiness, health-related quality of life, or neuro-behavioral performance. Moreover, follow-up assessments for one year indicated that, after completing the experiment, the participants assigned to TIB restriction continued to restrict their TIB (at their own initiative) by an average of approximately one hour.
   Conclusions: The results suggest good tolerance of chronic moderate TIB restriction, without detrimental effects, among older long sleepers.
C1 [Youngstedt, Shawn D.; Kline, Christopher E.; Zielinski, Mark R.; Devlin, Tina M.; Wilcox, Sara] Univ S Carolina, Dept Exercise Sci, Arnold Sch Publ Hlth, Columbia, SC 29208 USA.
   [Youngstedt, Shawn D.; Kline, Christopher E.] WJB Dorn VA Med Ctr, Columbia, SC USA.
   [Kripke, Daniel F.] Univ Calif San Diego, Dept Psychiat, San Diego, CA 92103 USA.
   [Kripke, Daniel F.] Scripps Clin Sleep Ctr, La Jolla, CA USA.
   [Bogan, Richard K.] SleepMed, Columbia, SC USA.
   [Hardin, James W.] Univ S Carolina, Dept Epidemiol & Biostat, Columbia, SC 29208 USA.
C3 University of South Carolina System; University of South Carolina
   Columbia; University of California System; University of California San
   Diego; Scripps Research Institute; University of South Carolina System;
   University of South Carolina Columbia
RP Youngstedt, SD (corresponding author), Univ S Carolina, Dept Exercise Sci, Arnold Sch Publ Hlth, 921 Assembly St,Room 301E, Columbia, SC 29208 USA.
EM syoungstedt@sc.edu
RI Hardin, James/P-4772-2019; Wilcox, Sara/GXV-7647-2022; youngstedt,
   shawn/AAA-3361-2021; Kripke, Daniel/M-9277-2019; Kline,
   Christopher/B-1477-2012
OI Kline, Christopher/0000-0003-1025-9430; Hardin,
   James/0000-0003-0506-5500
FU Career Development Award [HL 71560, VA (VISN-7)]; VA Merit Award
FX Research supported by HL 71560 and a VA (VISN-7) Career Development
   Award, and a VA Merit Award. Jeremiah Blankenship and Annie Lee assisted
   with this study.
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   Zielinski MR, 2008, J SLEEP RES, V17, P412, DOI 10.1111/j.1365-2869.2008.00673.x
NR 48
TC 18
Z9 18
U1 1
U2 4
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0161-8105
EI 1550-9109
J9 SLEEP
JI Sleep
PD NOV 1
PY 2009
VL 32
IS 11
BP 1467
EP 1479
DI 10.1093/sleep/32.11.1467
PG 13
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology
GA 518LM
UT WOS:000271693700010
PM 19928386
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Vancampfort, D
   Correll, CU
   Probst, M
   Sienaert, P
   Wyckaert, S
   De Herdt, A
   Knapen, J
   De Wachter, D
   De Hert, M
AF Vancampfort, Davy
   Correll, Christoph U.
   Probst, Michel
   Sienaert, Pascal
   Wyckaert, Sabine
   De Herdt, Amber
   Knapen, Jan
   De Wachter, Dirk
   De Hert, Marc
TI A review of physical activity correlates in patients with bipolar
   disorder
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Review
DE Bipolar disorder; Physical activity; Correlates
ID METABOLIC SYNDROME; ACTIVITY PARTICIPATION; ITALIAN PATIENTS; EXERCISE;
   OBESITY; BEHAVIOR; INTERVENTION; DETERMINANTS; ASSOCIATION; PREVENTION
AB Background: Existing studies do suggest that physical activity interventions may be feasible and have a role in promoting mental and physical health in patients with bipolar disorder. The present review evaluates systematically quantitative studies of correlates of physical activity in patients with bipolar disorder.
   Methods: We searched EMBASE, PsycINFO, PubMed, and CINAHL from their inception, combining the medical subject headings 'bipolar disorder' or 'mania' or 'manic depression' with 'physical activity' or 'physical inactivity' or 'exercise'.
   Results: Out of 40 potentially eligible studies, 11 papers evaluating 26 correlates were included. Correlates that were associated with lower physical activity participation were lower self-efficacy, presence of medical co-morbidity, lower educational status and social isolation. Less consistent variables associated with lower physical activity participation included higher BMI, older age, financial strains, not being connected to a health care service, and minority ethnicity. A larger study sample size was related to a higher proportion of significant associations (p = 0.04). Current gaps in literature which need to be examined more in detail are the role of psychiatric symptoms, environmental and policylevel factors.
   Limitations: The diversity of physical activity measures and subject samples prevented us to perform a meta-analysis.
   Conclusions: All significant correlates should be confirmed in prospective studies and interventions to improve the modifiable variables should be developed and evaluated. The reviewed data also demonstrate that validation studies on physical activity measurements are highly needed. (c) 2012 Elsevier B.V. All rights reserved.
C1 [Vancampfort, Davy; Probst, Michel; Sienaert, Pascal; Wyckaert, Sabine; Knapen, Jan; De Wachter, Dirk; De Hert, Marc] Catholic Univ Louvain, Univ Psychiat Ctr, B-3070 Kortenberg, Belgium.
   [Vancampfort, Davy; Probst, Michel; De Herdt, Amber; Knapen, Jan] Catholic Univ Louvain, Fac Kinesiol & Rehabil Sci, B-3000 Louvain, Belgium.
   [Correll, Christoph U.] Zucker Hillside Hosp, Glen Oaks, NY USA.
   [Correll, Christoph U.] Albert Einstein Coll Med, Bronx, NY 10467 USA.
C3 Universite Catholique Louvain; Universite Catholique Louvain; Northwell
   Health; Yeshiva University; Montefiore Medical Center; Albert Einstein
   College of Medicine
RP Vancampfort, D (corresponding author), Catholic Univ Louvain, Univ Psychiat Ctr, Campus Kortenberg,Leuvensesteenweg 517, B-3070 Kortenberg, Belgium.
EM Davy.Vancampfort@uc-kortenberg.be
RI Probst, Michel/ABE-6137-2020; Vancampfort, Davy/AAD-1987-2019; Correll,
   Christoph/D-3530-2011; sienaert, pascal/HTP-4217-2023; De Hert,
   Marc/AAH-6090-2021
OI Sienaert, Pascal/0000-0002-0650-415X; De Hert, Marc/0000-0003-4255-5920
FU AstraZeneca; Lundbeck JA; Janssen-Cilag; Eli Lilly; Pfizer;
   Sanofi-Aventis; Bristol-Myers Squibb
FX Dr. M. De Hert has been a consultant for, received grant/research
   support and honoraria from, and been on the speakers/advisory boards of
   AstraZeneca, Lundbeck JA, Janssen-Cilag, Eli Lilly, Pfizer,
   Sanofi-Aventis and Bristol-Myers Squibb. Dr. Sienaert has been on the
   speakers/advisory boards of AstraZeneca, Lundbeck JA, Janssen-Cilag, Eli
   Lilly, Servier, Glaxo-Smith-Kline, and Bristol-Myers Squibb Dr. C.U.
   Correll has been a consultant and/or advisor to or has received
   honoraria from: Actelion, Alexza; American Academy of Child and
   Adolescent Psychiatiy, AstraZeneca, Biotis, Bristol-Myers Squibb,
   Cephalon, Desitin, Eli Lilly, Gerson Lehrman Group, GSK, IntraCellular
   Therapies, Lundbeck, Medavante, Medscape, Merck, National Institute of
   Mental Health, Novartis, Ortho-McNeill/Janssen/J&J, Otsuka, Pfizer,
   ProPhase, Sunovion, Takeda and Teva. He has received grant support from
   BMS, Feinstein Institute for Medical Research, Janssen/J&J, National
   Institute of Mental Health (NIMH), National Alliance for Research in
   Schizophrenia and Depression (NARSAD), and Otsuka. The other authors
   declare no conflict of interest.
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NR 36
TC 100
Z9 101
U1 1
U2 76
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD MAR 5
PY 2013
VL 145
IS 3
BP 285
EP 291
DI 10.1016/j.jad.2012.07.020
PG 7
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA 086LX
UT WOS:000314686600002
PM 22889526
DA 2025-06-11
ER

PT J
AU Liu, L
   Qiu, L
   Xue, J
   Zhong, C
   Qin, MM
   Zhang, YF
   Xu, CM
   Xie, YF
   Yu, J
AF Liu, Li
   Qiu, Liang
   Xue, Jing
   Zhong, Chao
   Qin, Manman
   Zhang, Yifeng
   Xu, Chuanming
   Xie, Yanfei
   Yu, Jun
TI Saponins from Allium macrostemon Bulbs Attenuate Endothelial
   Inflammation and Acute Lung Injury via the NF-κB/VCAM-1 Pathway
SO MOLECULES
LA English
DT Article
DE saponins from Allium macrostemon bulbs; endothelial inflammation;
   VCAM-1; acute lung injury
ID CELL-ADHESION; SEVERE SEPSIS; NITRIC-OXIDE; EXPRESSION; DYSFUNCTION;
   MOLECULES
AB Endothelial inflammation is a multifaceted physiological process that plays a pivotal role in the pathogenesis and progression of diverse diseases, encompassing but not limited to acute lung infections like COVID-19, coronary artery disease, stroke, sepsis, metabolic syndrome, certain malignancies, and even psychiatric disorders such as depression. This inflammatory response is characterized by augmented expression of adhesion molecules and secretion of pro-inflammatory cytokines. In this study, we discovered that saponins from Allium macrostemon bulbs (SAMB) effectively inhibited inflammation in human umbilical vein endothelial cells induced by the exogenous inflammatory mediator lipopolysaccharide or the endogenous inflammatory mediator tumor necrosis factor-alpha, as evidenced by a significant reduction in the expression of pro-inflammatory factors and vascular cell adhesion molecule-1 (VCAM-1) with decreased monocyte adhesion. By employing the NF-kappa B inhibitor BAY-117082, we demonstrated that the inhibitory effect of SAMB on VCAM-1 expression may be attributed to the NF-kappa B pathway's inactivation, as characterized by the suppressed I kappa B alpha degradation and NF-kappa B p65 phosphorylation. Subsequently, we employed a murine model of lipopolysaccharide-induced septic acute lung injury to substantiate the potential of SAMB in ameliorating endothelial inflammation and acute lung injury in vivo. These findings provide novel insight into potential preventive and therapeutic strategies for the clinical management of diseases associated with endothelial inflammation.
C1 [Liu, Li; Qiu, Liang; Xue, Jing; Zhong, Chao; Qin, Manman; Zhang, Yifeng; Xu, Chuanming; Xie, Yanfei] Jiangxi Univ Chinese Med, Ctr Translat Med, Nanchang 330004, Peoples R China.
   [Zhong, Chao; Yu, Jun] Temple Univ, Lewis Katz Sch Med, Dept Cardiovasc Sci, Philadelphia, PA 19140 USA.
   [Zhong, Chao; Yu, Jun] Temple Univ, Ctr Metab Dis Res, Lewis Katz Sch Med, Philadelphia, PA 19140 USA.
C3 Jiangxi University of Traditional Chinese Medicine; Pennsylvania
   Commonwealth System of Higher Education (PCSHE); Temple University;
   Pennsylvania Commonwealth System of Higher Education (PCSHE); Temple
   University
RP Xie, YF (corresponding author), Jiangxi Univ Chinese Med, Ctr Translat Med, Nanchang 330004, Peoples R China.
EM 20070945@jxutcm.edu.cn
RI Zhong, Chao/F-3484-2010; Xu, Chuanming/ABH-9190-2020
FU National Natural Science Foundation of China
FX No Statement Available
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NR 50
TC 4
Z9 4
U1 2
U2 4
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1420-3049
J9 MOLECULES
JI Molecules
PD MAR
PY 2024
VL 29
IS 6
AR 1239
DI 10.3390/molecules29061239
PG 14
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA MK3K8
UT WOS:001193474200001
PM 38542876
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Dumontaud, M
   Korchia, T
   Khouani, J
   Lancon, C
   Auquier, P
   Boyer, L
   Fond, G
AF Dumontaud, Marion
   Korchia, Theo
   Khouani, Jeremy
   Lancon, Christophe
   Auquier, Pascal
   Boyer, Laurent
   Fond, Guillaume
TI Sexual dysfunctions in schizophrenia: Beyond antipsychotics. A
   systematic review
SO PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
LA English
DT Review
DE Sexual dysfunctions; Schizophrenia; Psychotropic drugs; Addiction;
   Prolactin; Depression
ID QUALITY-OF-LIFE; SERUM PROLACTIN LEVEL; RANDOMIZED OPEN-LABEL;
   DOUBLE-BLIND; 2ND-GENERATION ANTIPSYCHOTICS; CONVENTIONAL
   ANTIPSYCHOTICS; SCHIZOAFFECTIVE DISORDER; ADJUNCTIVE ARIPIPRAZOLE;
   REPRODUCTIVE HORMONES; RISPERIDONE
AB Background: Sexual dysfunctions (SD) in schizophrenia are frequent with strong impact on adherence and quality of life. Current recommendations stipulate to switch to prolactin-sparing antipsychotic in case of SD.
   Objectives: To synthetize in a systematic review data on the SD prevalence and the associated risk factors in schizophrenia (SZ).
   Methods: Medline, Google Scholar, Psychlnfo, and Cochrane were explored, without any year or language restriction.
   Results: Overall, 89 studies and 25,490 participants were included in the present review. SZ subjects aged 18-70 reported high SD frequency [30%-82%] (men [33%- 85%]; women [25%- 85%]). For SZ men erectile dysfunction [31%-95%] was the most frequent SD vs. loss of libido for women [31%-100%]. The following risk factors were associated with increased SD: 1. Illness severity (including psychotic symptomatology, early age at SZ onset, negative symptomatology, and continuous illness course), 2. Depressive symptomatology 3. Antipsychotics (especially first generation antipsychotics, risperidone and antipsychotic polytherapy). Switching to prolactin-sparing antipsychotics has shown effectiveness in some studies (especially aripiprazole). Antidepressants were not found to be associated with SD in SZ subjects.
   Conclusion: The prevalence of SD is high in SZ subjects. In addition to the current guidelines, the present review suggests that treating depressive symptoms may be a major intervention to improve SD in SZ subjects. Sociodemographic variables, physical illnesses, metabolic syndrome and peripheral inflammation have been poorly or never explored and should be included in future studies.
C1 [Dumontaud, Marion; Korchia, Theo; Khouani, Jeremy; Lancon, Christophe; Auquier, Pascal; Boyer, Laurent; Fond, Guillaume] Aix Marseille Univ, CEReSS Hlth Serv Res & Qual Life Ctr, Sch Med La Timone Med, Marseille, France.
   [Dumontaud, Marion; Korchia, Theo; Khouani, Jeremy; Auquier, Pascal; Boyer, Laurent; Fond, Guillaume] Aix Marseille Univ, AP HM, Dept Med Informat & Publ Hlth, Marseille, France.
   [Lancon, Christophe] Aix Marseille Univ, St Marguerite Hosp, AP HM, Marseille, France.
C3 Aix-Marseille Universite; Aix-Marseille Universite; Assistance
   Publique-Hopitaux de Marseille; Aix-Marseille Universite; Assistance
   Publique-Hopitaux de Marseille
RP Fond, G (corresponding author), Aix Marseille Univ, Fac Med, Sect Timone, EA 3279 CEReSS Ctr Etud & Rech Serv Sante & Quali, 27 Blvd Jean Moulin, F-13005 Marseille, France.
EM guillaume.fond@ap-hm.fr
RI Fond, Guillaume/D-7646-2011; Boyer, Laurent/E-5728-2016
OI Boyer, Laurent/0000-0003-1229-6622; Korchia, Theo/0000-0002-6392-9322
FU Assistance Publique des Hopitaux de Marseille (AP-HM); Aix-Marseille
   University
FX This work was funded by Assistance Publique des Hopitaux de Marseille
   (AP-HM) and Aix-Marseille University.
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NR 132
TC 28
Z9 29
U1 1
U2 27
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0278-5846
EI 1878-4216
J9 PROG NEURO-PSYCHOPH
JI Prog. Neuro-Psychopharmacol. Biol. Psychiatry
PD MAR 2
PY 2020
VL 98
AR 109804
DI 10.1016/j.pnpbp.2019.109804
PG 13
WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA JV7FV
UT WOS:000502527600026
PM 31711954
OA Green Submitted, Bronze
DA 2025-06-11
ER

PT J
AU Shimada, S
   Hasegawa, K
   Wada, H
   Terashima, S
   Satoh-Asahara, N
   Yamakage, H
   Kitaoka, S
   Akao, M
   Shimatsu, A
   Takahashi, Y
AF Shimada, Sayaka
   Hasegawa, Koji
   Wada, Hiromichi
   Terashima, Sachiko
   Satoh-Asahara, Noriko
   Yamakage, Hajime
   Kitaoka, Shuji
   Akao, Masaharu
   Shimatsu, Akira
   Takahashi, Yuko
TI High Blood Viscosity Is Closely Associated With Cigarette Smoking and
   Markedly Reduced by Smoking Cessation
SO CIRCULATION JOURNAL
LA English
DT Article
DE Blood rheology; Cardiovascular risk; Smoking
ID METABOLIC SYNDROME; RHEOLOGY; PRESSURE; DISEASE
AB Background: Cigarette smoking is an independent risk factor for cardiovascular events such as myocardial infarction and stroke. To date, a useful and convenient method of predicting such events in smokers has not been established. The rheological properties of blood assessed by the microchannel method reflect the blood's viscosity and the state of microthrombus formation, which may predict cardiovascular thrombotic events.
   Methods and Results: Blood fluidity was assessed in 74 smoking patients (54 men, 20 women, mean age 57.9 years) by measuring the blood passage time (BPT) in an aliquot (100 mu l) of blood using the Micro Channel Array Flow Analyzer. BPT was significantly related with smoking variables such as daily consumption of tobacco (r=0.236, P=0.044), Brinkman's index (r=0.252, P=0.033), the Fagerstrom Test for Nicotine Dependence (r=0.257, P=0.029), and the score of a self-rating depression scale (r=0.236, P<0.05). Multivariate regression analysis revealed that an independent BPT determinant was daily consumption of tobacco (r=0.326, P=0.045). Furthermore, smoking cessation markedly decreased BPT from 63.0 s to 49.7 s (P=0.002) at 3 months after the start of therapy.
   Conclusions: Unfavorable blood rheology is closely associated with cigarette smoking and may reflect increased cardiovascular risk in smokers. The study results also suggest that such risk can be reduced after only 3 months of smoking cessation. (Circ J 2011; 75: 185-189)
C1 [Hasegawa, Koji] Natl Hosp Org, Kyoto Med Ctr, Div Translat Res, Clin Res Inst,Fushimi Ku, Kyoto 6128555, Japan.
   [Terashima, Sachiko; Kitaoka, Shuji] Natl Hosp Org, Kyoto Med Ctr, Hlth Screening Ctr, Kyoto 6128555, Japan.
   [Takahashi, Yuko] Nara Womens Univ, Hlth Adm Ctr, Nara 630, Japan.
C3 Nara Womens University
RP Hasegawa, K (corresponding author), Natl Hosp Org, Kyoto Med Ctr, Div Translat Res, Clin Res Inst,Fushimi Ku, 1-1 Mukaihata Cho, Kyoto 6128555, Japan.
EM koj@kuhp.kyoto-u.ac.jp
RI TAKAHASHI, Yuko/GYR-2934-2022; Shimatsu, Akira/I-3856-2019
OI Wada, Hiromichi/0000-0002-8980-224X
FU Ministry of Health, Labour and Welfare for Research on Economic Effects
   of Various Strategies for Smoking Cessation
FX This study owes much to the generous cooperation of Messrs Yuko Iida,
   Shuichi Ura, Akira Yamada, Yosuke Sasaki, and Kazuya Muranaka at the
   National Hospital Organization Kyoto Medical Center. This study was
   partly sponsored by a Grant-in-Aid from the Ministry of Health, Labour
   and Welfare for Research on Economic Effects of Various Strategies for
   Smoking Cessation.
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NR 14
TC 51
Z9 56
U1 0
U2 11
PU JAPANESE CIRCULATION SOC
PI TOYKO
PA 18TH FLOOR IMPERIAL HOTEL TOWER, 1-1-1 UCHISAIWAI-CHO CHIYODA-KU, TOYKO,
   100-0011, JAPAN
SN 1346-9843
EI 1347-4820
J9 CIRC J
JI Circ. J.
PD JAN
PY 2011
VL 75
IS 1
BP 185
EP 189
DI 10.1253/circj.CJ-10-0335
PG 5
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 701JN
UT WOS:000285814300030
PM 21071876
OA Bronze
DA 2025-06-11
ER

PT J
AU Lü, JX
   Jiang, C
   Drabick, JJ
   Joshi, M
   Perimbeti, S
AF Lu, Junxuan
   Jiang, Cheng
   Drabick, Joseph J.
   Joshi, Monika
   Perimbeti, Stuthi
TI Angelica gigas Nakai (Korean Dang-gui) Root Alcoholic Extracts in
   Health Promotion and Disease Therapy - active Phytochemicals and In
   Vivo Molecular Targets
SO PHARMACEUTICAL RESEARCH
LA English
DT Article
DE decursin; decursinol; decursinol angelate; nodakenin; ROCK1/2
ID DECURSINOL ANGELATE; COMPOUND; PHARMACOKINETICS; IDENTIFICATION; MICE;
   PYRANOCOUMARINS; DECARBOXYLASE; ANTIANDROGEN; INHIBITION; METABOLISM
AB Angelica gigas Nakai (AGN) root is a medicinal herbal widely used in traditional medicine in Korea. AGN root ethanolic extracts have been marketed as dietary supplements in the United States for memory health and pain management. We have recently reviewed the pharmacokinetics (PK) and first-pass hepatic metabolism of ingested AGN supplements in humans for the signature pyranocoumarins decursin (D, C-max 1x), decursinol angelate (DA, C-max similar to 10x) and their common botanical precursor and hepatic metabolite decursinol (DOH, C-max similar to 1000x). Here we update in vivo medicinal activities of AGN and/or its pyranocoumarins and furanocoumarin nodakenin in cancer, pain, memory loss, cerebral ischemia reperfusion stroke, metabolic syndrome and vascular endothelial dysfunctions, anxiety, sleep disorder, epilepsy, inflammatory bowel disease, osteoporosis and osteoarthritis. Given their polypharmacology nature, the pertinent mechanisms of action are likely misrepresented by many cell culture studies that did not consider the drug metabolism knowledge. We report here Rho-associated protein kinases (ROCK1/2) as novel targets for DA and DOH. Combining with published inhibitory activity of DOH on acetylcholinesterase, agonist activity of DOH and antagonist/degrader activity of DA/D on androgen and estrogen receptors, D/DA promoting activity for glutamic acid decarboxylase (GAD)- gamma-aminobutyric acid (GABA) inhibitory axis and inhibition of glutamate dehydrogenase (GDH), monoamine oxidase-A (MAO-A) and transient receptor potential vanilloid 1 (TRPV1), we postulate their contributions to neuro-cognitive, metabolic, oncologic, vascular and other beneficial bioactivities of AGN extracts. A clinical trial is being planned for an AGN extract to manage side effects of androgen deprivation therapy in prostate cancer patients.
C1 [Lu, Junxuan; Jiang, Cheng] Penn State Univ, Dept Pharmacol, Coll Med, Hershey, PA 17033 USA.
   [Lu, Junxuan; Drabick, Joseph J.; Joshi, Monika; Perimbeti, Stuthi] Penn State Univ, Penn State Canc Inst, Hershey, PA 17033 USA.
   [Lu, Junxuan; Jiang, Cheng] Penn State Univ, Ctr Cannabis & Nat Prod Pharmaceut, Coll Med, Hershey, PA 17033 USA.
   [Drabick, Joseph J.; Joshi, Monika; Perimbeti, Stuthi] Penn State Univ, Coll Med, Dept Med, Div Hematol & Oncol, Hershey, PA 17033 USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE);
   Pennsylvania State University; Penn State Health; Pennsylvania
   Commonwealth System of Higher Education (PCSHE); Pennsylvania State
   University; Penn State Health; Pennsylvania Commonwealth System of
   Higher Education (PCSHE); Pennsylvania State University; Penn State
   Health; Pennsylvania Commonwealth System of Higher Education (PCSHE);
   Pennsylvania State University; Penn State Health
RP Lü, JX (corresponding author), Penn State Univ, Dept Pharmacol, Coll Med, Hershey, PA 17033 USA.; Lü, JX (corresponding author), Penn State Univ, Penn State Canc Inst, Hershey, PA 17033 USA.; Lü, JX (corresponding author), Penn State Univ, Ctr Cannabis & Nat Prod Pharmaceut, Coll Med, Hershey, PA 17033 USA.
EM junxuanlu@pennstatehealth.psu.edu
FU National Cancer Institute
FX We thank the professional technical staff at Eurofins KinomeScan and
   Reaction Biology, Inc. for discussions of screening outcomes and follow
   up validations.
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NR 105
TC 0
Z9 0
U1 2
U2 2
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0724-8741
EI 1573-904X
J9 PHARM RES-DORDR
JI Pharm. Res.
PD JAN
PY 2025
VL 42
IS 1
BP 25
EP 47
DI 10.1007/s11095-024-03809-9
EA JAN 2025
PG 23
WC Chemistry, Multidisciplinary; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Pharmacology & Pharmacy
GA U2Y4A
UT WOS:001393052600001
PM 39779619
OA hybrid
DA 2025-06-11
ER

PT J
AU Suhaimi, SA
   Müller, AM
   Hafiz, E
   Khoo, S
AF Suhaimi, Saiful Adli
   Muller, Andre Matthias
   Hafiz, Eliza
   Khoo, Selina
TI Occupational sitting time, its determinants and intervention strategies
   in Malaysian office workers: a mixed-methods study
SO HEALTH PROMOTION INTERNATIONAL
LA English
DT Article
DE sedentary behavior; Asia; health behavior; office workers; determinants;
   social-ecological model
ID PHYSICAL-ACTIVITY; SEDENTARY TIME; HEALTH-PROMOTION; ASSOCIATION;
   ADULTS; EPIDEMIOLOGY; METAANALYSIS; BEHAVIOR; DISEASE
AB Adults who accumulate a lot of sedentary time per day are at an increased risk of metabolic syndrome, type 2 diabetes, and hypertension. Prolonged sitting is also associated with depression, anxiety, bipolar disorder and schizophrenia. With the increase in desk-based office work, many office workers spend long hours sitting at the workplace. The aim of this study was to assess occupational sitting time in Malaysian government office workers, and investigate determinants of occupational sitting time and potential strategies to interrupt sitting time. We conducted a mixed-methods study consisting of a survey and focus group discussions (FGDs). A total of 1338 office workers from 24 Malaysian ministries completed the Occupational Sitting and Physical Activity Questionnaire. Twenty-nine office workers who spent at least 7 h per day sitting at work participated in FGDs. We enquired about knowledge, awareness and perceptions related to prolonged sitting time, barriers and facilitators to sitting time at work, and potential intervention strategies. Mean daily sitting time at work was 5.96 h (standard deviation = 1.37 h). FDGs confirmed barriers and facilitators to sitting time in accordance with the social-ecological model for health. Intrapersonal, social and physical environmental factors as well as organizational culture and organizational policy were mentioned to affect occupational sitting time. The results show that Malaysian government office workers spent a significant amount of time sitting at work and we identified multi-level factors influencing sitting time. A smartphone-based intervention to interrupt sitting time at work was suggested and is currently being tested.
   Lay Summary Sedentary behavior is associated with adverse health outcomes including non-communicable diseases and mental disorders. With the increase in desk-based office work, many office workers spend long hours sitting at the workplace. Our study assessed occupational sitting time in Malaysian government office workers, and investigated determinants of occupational sitting time and potential strategies to interrupt sitting time. We conducted a survey and focus group discussions (FGDs). A total of 1338 office workers completed the Occupational Sitting and Physical Activity Questionnaire. Twenty-nine office workers who spent at least 7 h per day sitting at work participated in FGDs. We enquired about knowledge, awareness and perceptions related to prolonged sitting time, barriers and facilitators to sitting time at work, and potential intervention strategies. The mean daily sitting time at work was 5.96 h (standard deviation = 1.37 h). FGD participants mentioned that intrapersonal, social and physical environmental factors as well as organizational culture and organizational policy affected occupational sitting time. They suggested a smartphone-based intervention to interrupt sitting time at work.
C1 [Suhaimi, Saiful Adli; Hafiz, Eliza; Khoo, Selina] Univ Malaya, Ctr Sport & Exercise Sci, Kuala Lumpur 5060, Malaysia.
   [Suhaimi, Saiful Adli] Minist Hlth Malaysia, Inst Hlth Behav Res, 1 Jalan Setia Murni U13-52, Shah Alam 40170, Selangor, Malaysia.
   [Muller, Andre Matthias] Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, 12 Sci Dr 2,10-01, Singapore 117549, Singapore.
   [Muller, Andre Matthias] Natl Univ Hlth Syst, 12 Sci Dr 2,10-01, Singapore 117549, Singapore.
C3 Universiti Malaya; Kementerian Kesihatan Malaysia; National University
   of Singapore; National University of Singapore
RP Khoo, S (corresponding author), Univ Malaya, Ctr Sport & Exercise Sci, Kuala Lumpur 5060, Malaysia.
EM selina@um.edu.my
RI Khoo, Selina/B-3962-2009; Muller, Andre Matthias/P-3152-2014; Hafiz,
   Eliza/AAU-9484-2020
OI Khoo, Selina/0000-0002-3090-9309; Muller, Andre
   Matthias/0000-0001-5770-6723; Hafiz, Eliza/0000-0001-5172-4189
FU Universiti Malaya [RP047A-17HTM]
FX This study was supported by a grant from Universiti Malaya
   (RP047A-17HTM). The funder had no role in any aspects of the research.
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NR 46
TC 6
Z9 6
U1 3
U2 29
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0957-4824
EI 1460-2245
J9 HEALTH PROMOT INT
JI Health Promot. Int.
PD APR 29
PY 2022
VL 37
IS 2
AR daab149
DI 10.1093/heapro/daab149
EA SEP 2021
PG 10
WC Health Policy & Services; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services; Public, Environmental & Occupational
   Health
GA 0W0FX
UT WOS:000788715200024
PM 34516620
DA 2025-06-11
ER

PT J
AU Basile, L
   Condorelli, RA
   Calogero, AE
   Cannarella, R
   Barbagallo, F
   Crafa, A
   Aversa, A
   La Vignera, S
AF Basile, Livia
   Condorelli, Rosita A.
   Calogero, Aldo E.
   Cannarella, Rossella
   Barbagallo, Federica
   Crafa, Andrea
   Aversa, Antonio
   La Vignera, Sandro
TI Red Wine and Sexual Function in Men: An Original Point of View
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Article
DE red wine; sexual function; erectile dysfunction
ID ENDOTHELIAL GROWTH-FACTOR; ERECTILE DYSFUNCTION; NITRIC-OXIDE;
   CARDIOVASCULAR-DISEASE; ANTIOXIDANT CAPACITY; HYDROGEN-SULFIDE;
   HEALTH-BENEFITS; ALCOHOL; POLYPHENOLS; RESVERATROL
AB Red wine is a rich source of nutrients whose biological properties have inspired numerous scientific studies. Indeed, it has been widely reported that there is a correlation between the positive health effects of moderate consumption of red wine and its phenolic content, which, due to its antioxidant activity, has proved to be useful in the improvement of various diseases, such as cardiovascular diseases, metabolic syndrome, cognitive disorders, depression, and cancer. It is a common opinion that the antioxidant activity of red wine is to be ascribed to its entire content of polyphenols, which act synergistically and not as a single component. Furthermore, this health-promoting effect of red wine can also be linked to its ethanol content, which has shown a wide array of biological properties. Beyond this evidence, very little is known about a possible correlation between moderate consumption of red wine and male sexual function. This brief review aimed to evaluate the effects of moderate consumption of red wine on erectile function. To accomplish this, Pubmed and Google Scholar databases were searched to retrieve the most relevant studies on this topic. The evidence so far collected has shown that red wine, if consumed in moderation, can be potentially beneficial for patients with erectile dysfunction as well as can positively influence reproductive function through mechanisms that depend on the vasorelaxant properties of red wine and its antioxidant properties.
C1 [Basile, Livia; Condorelli, Rosita A.; Calogero, Aldo E.; Cannarella, Rossella; Barbagallo, Federica; Crafa, Andrea; La Vignera, Sandro] Univ Catania, Dept Clin & Expt Med, I-95125 Catania, Italy.
   [Aversa, Antonio] Magna Graecia Univ Catanzaro, Dept Expt & Clin Med, I-88100 Catanzaro, Italy.
C3 University of Catania; Magna Graecia University of Catanzaro
RP La Vignera, S (corresponding author), Univ Catania, Dept Clin & Expt Med, I-95125 Catania, Italy.
EM livia.basile@unict.it; rosita.condorelli@unict.it; acaloger@unict.it;
   rossella.cannarella@phd.unict.it; federica.barbagallo11@gmail.com;
   andrea.crafa@outlook.it; aversa@unicz.it; sandrolavignera@unict.it
RI Calogero, Aldo/AAA-9538-2021; Cannarella, Rossella/AAB-6486-2021; La
   Vignera, Sandro/AAR-1589-2020; Aversa, Antonio/O-3151-2019; Basile,
   Livia/AAR-6833-2021; Crafa, Andrea/AAV-9892-2021; Barbagallo,
   Federica/AAB-6446-2021
OI Cannarella, Rossella/0000-0003-4599-8487; Calogero, Aldo
   E./0000-0001-6950-335X; Aversa, Antonio/0000-0002-2989-2618; La Vignera,
   Sandro/0000-0002-7113-2372; Condorelli, Rosita
   Angela/0000-0002-5217-9343
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NR 73
TC 0
Z9 1
U1 0
U2 3
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD JUN
PY 2023
VL 12
IS 12
AR 3883
DI 10.3390/jcm12123883
PG 11
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA K3EC6
UT WOS:001015293200001
PM 37373577
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Cayetano-Alcaraz, AA
   Tharakan, T
   Chen, RZ
   Sofikitis, N
   Minhas, S
AF Cayetano-Alcaraz, Axel Alberto
   Tharakan, Tharu
   Chen, Runzhi
   Sofikitis, Nikolaos
   Minhas, Suks
TI The management of erectile dysfunction in men with diabetes mellitus
   unresponsive to phosphodiesterase type 5 inhibitors
SO ANDROLOGY
LA English
DT Review
DE antioxidants; combination; diabetes complications; complications;
   diabetes mellitus; drug therapy; erectile dysfunction; hypogonadism;
   intracavernosal injection therapy; low-intensity extracorporeal
   shockwave therapy; non-responders to PDE5i; penile prosthesis;
   phosphodiesterase 5 inhibitors; stem-cell therapy; vacuum pump
ID INTRACAVERNOSAL INJECTION THERAPY; PROPIONYL-L-CARNITINE;
   QUALITY-OF-LIFE; INTRAURETHRAL ALPROSTADIL; SEXUAL FUNCTION;
   TESTOSTERONE UNDECANOATE; ENDOTHELIAL DYSFUNCTION; CARDIOVASCULAR RISK;
   METABOLIC SYNDROME; HIGH PREVALENCE
AB Introduction Erectile dysfunction is associated with diabetes mellitus with an estimated prevalence of 52.5% in the diabetic population. The first-line therapy for erectile dysfunction is phosphodiesterase type 5 inhibitors, but data suggest that diabetic men may be less responsive than non-diabetic men. Thus, other treatments, including intracavernosal injections, intraurethral prostaglandin, vacuum erection devices and penile prosthetic surgery, should be considered in management of diabetic men with erectile dysfunction refractory to phosphodiesterase type 5 inhibitors. Furthermore, combination therapy of phosphodiesterase type 5 inhibitors and other oral treatments such as arginine or l-carnitine may have synergistic effects resulting in better outcomes. In addition, there are novel therapies such as low-intensity shockwave therapy and stem-cell therapy, which may also be effective in targeted treatment modalities. Furthermore, studies suggest that erectile dysfunction can be improved by targeting concurrent comorbidities or metabolic diseases such as depression, hypertension, hypogonadism, and dyslipidaemia. We present an evidence-based narrative review focusing on the management of erectile dysfunction in diabetic men who have not responded to phosphodiesterase type 5 inhibitors. Conclusions Both clinicians and patients should be aware of the different management options in diabetic patients who have not responded to phosphodiesterase type 5 inhibitors.
C1 [Cayetano-Alcaraz, Axel Alberto; Tharakan, Tharu; Minhas, Suks] Imperial Coll Healthcare NHS Trust, Charing Cross Hosp, Dept Urol, London, England.
   [Chen, Runzhi] Imperial Coll London, Fac Med, London, England.
   [Sofikitis, Nikolaos] Univ Ioannina, Dept Urol, Sch Med, Ioannina, Greece.
C3 Imperial College London; Imperial College London; University of Ioannina
RP Cayetano-Alcaraz, AA (corresponding author), Imperial Coll Healthcare NHS Trust, Charing Cross Hosp, Dept Urol, London, England.
EM draxelcayetano@andrologia.com.mx
RI Cayetano Alcaraz, Axel Alberto/AAN-8015-2021; Chen, Runzhi/LLK-2019-2024
OI Cayetano Alcaraz, Axel Alberto/0000-0001-7041-0564
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NR 115
TC 28
Z9 28
U1 1
U2 11
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2047-2919
EI 2047-2927
J9 ANDROLOGY-US
JI Andrology
PD FEB
PY 2023
VL 11
IS 2
SI SI
BP 257
EP 269
DI 10.1111/andr.13257
EA AUG 2022
PG 13
WC Andrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 8J1WT
UT WOS:000842377500001
PM 35929992
OA hybrid
DA 2025-06-11
ER

PT J
AU Khoshbakht, Z
   Torbati, M
   Khodaie, L
   Khashabi, E
AF Khoshbakht, Zoleikha
   Torbati, Mohammadali
   Khodaie, Laleh
   Khashabi, Ehsan
TI Topical Oral Medicaments in Traditional Persian Medicine
SO CRESCENT JOURNAL OF MEDICAL AND BIOLOGICAL SCIENCES
LA English
DT Review
DE Ethno-medicine; Ethno-pharmacology; Traditional Persian medicine; Oral;
   medicaments
ID METABOLIC SYNDROME; ASSOCIATION
AB Objectives: Traditional, topically used oral medicaments are of great importance in the treatment of both oral and systemic diseases. Therefore, the aim of this study was to review the indications of various drug delivery forms and active ingredients of currently used medications in complementary medicine, as well as the results of recent research to find any possible conformity between their traditional and recent pharmaceutical properties.
   Methods: In this review article, different resources including electronica databases, hand searching, the screening of reference lists and contacting experts were extensively performed, followed by categorizing the extracted data.
   Results: Based on the results, 6 drug forms were found in gaseous, liquid, and solid states with more than 70 formulations. Liquid and gaseous forms were mainly used to manage systemic conditions and solid forms were mainly applied for local treatments. In addition, the investigation of about 50 herbal components showed that the traditional therapeutic effects of the vast majority of the ingredients were in line with those of the recent studies. However, no clinical studies were found regarding the traditionally mentioned systemic effects after the topical use of this medicament in the form of gargles or mouthrinse.
   Conclusions: In general, the side effects of oral and injectable drugs, as well as the specific advantages of oral mucosa in achieving the topical and systemic effects and the variety of the plant components of Iranian traditional oral medicament might have high potentials for finding new drugs and improving treatment strategies of some systemic diseases such as central nervous system diseases and depression.
C1 [Khoshbakht, Zoleikha; Khodaie, Laleh] Tabriz Univ Med Sci, Fac Tradit Med, Dept Phytopharm, Tabriz, Iran.
   [Torbati, Mohammadali] Tabriz Univ Med Sci, Fac Nutr, Dept Food Sci & Technol, Tabriz, Iran.
   [Khodaie, Laleh] Tabriz Univ Med Sci, Med Philosophy & Hist Res Ctr, Tabriz, Iran.
   [Khashabi, Ehsan] Urmia Univ Med Sci, Dept Periodont, Fac Dent, Orumiyeh, Iran.
C3 Tabriz University of Medical Science; Tabriz University of Medical
   Science; Tabriz University of Medical Science; Urmia University of
   Medical Sciences
RP Khodaie, L (corresponding author), Tabriz Univ Med Sci, Fac Tradit Med, Dept Phytopharm, Tabriz, Iran.; Khodaie, L (corresponding author), Tabriz Univ Med Sci, Med Philosophy & Hist Res Ctr, Tabriz, Iran.
EM khodaiel@gmail.com
RI Torbati, Mohammadali/D-7356-2017; Khodaie, Laleh/G-1424-2017
FU Tabriz University of Medical Sciences [5/D/517567]
FX This review article was part of a Ph.D. thesis in traditional medicine
   which was funded by Tabriz University of Medical Sciences (grant number:
   5/D/517567).
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NR 24
TC 0
Z9 0
U1 0
U2 1
PU ARAS PART MEDICAL INT PRESS
PI TABRIZ
PA NO 1, S SHAREATI ST, 5138815941, TABRIZ, 00000, IRAN
SN 2148-9696
J9 CRESCENT J MED BIOL
JI Crescent J. Med. Biol. Sci.
PD JAN
PY 2020
VL 7
IS 1
BP 17
EP 21
PG 5
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA JZ1YU
UT WOS:000504900900003
DA 2025-06-11
ER

PT J
AU Haque, M
   Sanyal, AJ
AF Haque, M
   Sanyal, AJ
TI The metabolic abnormalities associated with non-alcoholic fatty liver
   disease
SO BEST PRACTICE & RESEARCH CLINICAL GASTROENTEROLOGY
LA English
DT Review
DE insulin resistance; syndrome-X; fatty liver; fatty liver disease;
   steatohepatitis; non-alcoholic fatty liver disease; non-alcoholic
   steatohepatitis; oxidant stress; lipid metabolism
ID REVERSES INSULIN-RESISTANCE; FASTING PLASMA-GLUCOSE; DIABETES-MELLITUS;
   PROTEIN-KINASE; MICE LACKING; ADIPOSE-TISSUE; TNF-ALPHA;
   PHOSPHATIDYLINOSITOL 3-KINASE; INDUCED PHOSPHORYLATION; INTRAVENOUS
   GLUCOSE
AB Non-alcoholic fatty liver disease (NAFLD) is a common disorder in the Western hemisphere. It encompasses two histological lesions: fatty liver and steatohepatitis. A large body of literature indicates that insulin resistance is a key pathophysiological abnormality in patients with NAFLD. Insulin resistance results from a complex interplay between the major targets of insulin action, i.e. muscle, adipose tissue and liver, versus the ability of the pancreatic islet 0 cells to compensate for insulin resistance by increasing insulin production. The metabolic and clinical profile associated with insulin resistance is thus defined by the factors that produce and maintain insulin resistance and the effects of decreased insulin sensitivity on various insulin-dependent pathways. The major metabolic defects associated with insulin resistance are increased peripheral lipolysis, increased hepatic glucose output due to increased gluconeogenesis and increased lipid oxidation. This is associated with an oxidative stress in the liver that may be compounded by additional pathophysiological abnormalities. While much work remains to be done, the current understanding of the pathogenesis of NAFLD provides direction for both future investigation and development of therapeutic trials.
C1 Virginia Commonwealth Univ, Dept Internal Med, Div Gastroenterol, Richmond, VA 23298 USA.
   Virginia Commonwealth Univ, Dept Internal Med, Div Hepatol & Nutr, Richmond, VA 23298 USA.
C3 Virginia Commonwealth University; Virginia Commonwealth University
RP Virginia Commonwealth Univ, Dept Internal Med, Div Gastroenterol, MCV Box 980711, Richmond, VA 23298 USA.
EM ajsanyal@hsc.vcu.edu
FU NIDDK NIH HHS [K 24 DK02755-02] Funding Source: Medline
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NR 118
TC 107
Z9 117
U1 3
U2 15
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1521-6918
EI 1532-1916
J9 BEST PRACT RES CL GA
JI Best Pract. Res. Clin. Gastroenterol.
PD OCT
PY 2002
VL 16
IS 5
BP 709
EP 731
DI 10.1053/bega.2002.0325
PG 23
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 621VX
UT WOS:000179612700005
PM 12406441
DA 2025-06-11
ER

PT J
AU Mzhelskaya, KV
   Shipelin, VA
   Shumakova, AA
   Musaeva, AD
   Soto, JS
   Riger, NA
   Trusov, NV
   Kirbaeva, NV
   Apryatin, SA
   Gmoshinski, IV
AF Mzhelskaya, Kristina, V
   Shipelin, Vladimir A.
   Shumakova, Antonina A.
   Musaeva, Anna D.
   Soto, Jorge S.
   Riger, Nikolay A.
   Trusov, Nikita, V
   Kirbaeva, Natalya, V
   Apryatin, Sergey A.
   Gmoshinski, Ivan, V
TI Effects of quercetin on the neuromotor function and behavioral responses
   of Wistar and Zucker rats fed a high-fat and high-carbohydrate diet
SO BEHAVIOURAL BRAIN RESEARCH
LA English
DT Article
DE Obesity; In vivo model; Rats; Leptin; Neuromotor responses; Behavioral
   reactions
ID METABOLIC SYNDROME; GRIP STRENGTH; HYPERLIPIDEMIA; MODELS; LEPTIN
AB Quercetin can affect some pathological manifestations in obesity. The mechanism underlying the presumed therapeutic effect of quercetin is probably related to the influence on the central processes regulating energy homeostasis. Thus, the purpose of this study was to examine the effect of quercetin on the neuromotor and behavioral functions in Zucker (Z) and Wistar (W) rats with genetically and/or diet-induced obesity. Rats of both strains received balanced or high fat and fructose diet (HFCD) in a 62-day experiment or the same diets supplemented with quercetin at the dose of 50 mg/kg body weight per day. The neuromotor function and behavioral responses were examined using the grip strength test, open field test, elevated plus maze test and conditioned passive avoidance response (CPAR) test. The quercetin potentiated a decrease in anxiety in W rats consumed HFCD and this effect was absent in Z rats with a defect in the leptin receptor gene. In contrast, quercetin increased locomotor activity and impaired short-term memory in the CPAR test only in Z rats with the absence of normal leptin reception. Against the background of the identified changes quercetin exerted significant effects on the lipid and nitrogen metabolism indices such as HDL cholesterol, AsAT/AlAT activities ratio, urea level as well as body and fat mass that were different in Z and W rats. The data obtained show that the effects of quercetin on behavior vary significantly between two strains of rat and consequently are mediated by processes of leptin reception.
C1 [Mzhelskaya, Kristina, V; Shipelin, Vladimir A.; Shumakova, Antonina A.; Musaeva, Anna D.; Soto, Jorge S.; Riger, Nikolay A.; Trusov, Nikita, V; Kirbaeva, Natalya, V; Apryatin, Sergey A.; Gmoshinski, Ivan, V] Fed Res Ctr Nutr & Biotechnol, Ustinsky Pr 2-14, Moscow 109240, Russia.
   [Shipelin, Vladimir A.] Plekhanov Russian Univ Econ, Moscow, Russia.
C3 Federal Research Center of Nutrition, Biotechnology & Food Safety;
   Plekhanov Russian University of Economics
RP Shipelin, VA (corresponding author), Fed Res Ctr Nutr & Biotechnol, Ustinsky Pr 2-14, Moscow 109240, Russia.
EM kristik13@yandex.ru; v.shipelin@ya.ru; antonina_sh@list.ru;
   anya.evstratova@mail.ru; jsotoc@mail.ru; riger@ion.ru;
   nikkitosu@yandex.ru; n.kirbaeva@gmail.com; apryatin@mail.ru;
   gmosh@ion.ru
RI Gmoshinski, Ivan/K-6755-2018; Shipelin, Vladimir/N-4692-2016; Musaeva,
   Anna/AAQ-3797-2020; Soto, Jorge/JXW-5802-2024; Shumakova,
   Antonina/R-8508-2016; Trusov, Nikita/P-1942-2016; Apryatin,
   Sergey/R-5394-2016
FU Russian Scientific Foundation [17-16-01043]; Russian Science Foundation
   [17-16-01043] Funding Source: Russian Science Foundation
FX The work was supported by a grant from the Russian Scientific Foundation
   No. 17-16-01043 "Search for effector units of metabolism regulated by
   alimentary factors in obesity for the development of innovative
   specialized food".
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NR 32
TC 17
Z9 21
U1 0
U2 18
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0166-4328
EI 1872-7549
J9 BEHAV BRAIN RES
JI Behav. Brain Res.
PD JAN 27
PY 2020
VL 378
AR 112270
DI 10.1016/j.bbr.2019.112270
PG 13
WC Behavioral Sciences; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Behavioral Sciences; Neurosciences & Neurology
GA LD5HB
UT WOS:000526059200005
PM 31585131
DA 2025-06-11
ER

PT J
AU Soria-Chacartegui, P
   Villapalos-Garcia, G
   Zubiaur, P
   Abad-Santos, F
   Koller, D
AF Soria-Chacartegui, Paula
   Villapalos-Garcia, Gonzalo
   Zubiaur, Pablo
   Abad-Santos, Francisco
   Koller, Dora
TI Genetic Polymorphisms Associated With the Pharmacokinetics,
   Pharmacodynamics and Adverse Effects of Olanzapine, Aripiprazole and
   Risperidone
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Review
DE antipsychotics; pharmacogenetics; metabolism; genetic polymorphism;
   pharmacokinetics
ID INDUCED WEIGHT-GAIN; PHARMACOGENETICS IMPLEMENTATION CONSORTIUM; D2
   RECEPTOR GENE; ANTIPSYCHOTIC-DRUGS; 1ST-EPISODE SCHIZOPHRENIA;
   PLASMA-CONCENTRATIONS; TAQ1A POLYMORPHISM; METABOLIC SYNDROME; NEGATIVE
   SYMPTOMS; CLINICAL-RESPONSE
AB Olanzapine, aripiprazole and risperidone are atypical antipsychotics or neuroleptics widely used for schizophrenia treatment. They induce various adverse drug reactions depending on their mechanisms of action: metabolic effects, such as weight gain and alterations of glucose and lipid metabolism; hyperprolactinemia and extrapyramidal effects, such as tremor, akathisia, dystonia, anxiety and distress. In this review, we listed polymorphisms associated with individual response variability to olanzapine, aripiprazole and risperidone. Olanzapine is mainly metabolized by cytochrome P450 enzymes, CYP1A2 and CYP2D6, whereas aripiprazole and risperidone metabolism is mainly mediated by CYP2D6 and CYP3A4. Polymorphisms in these genes and other enzymes and transporters, such as enzymes from the uridine 5'-diphospho-glucuronosyltransferase (UGT) family and ATP-binding cassette sub-family B member 1 (ABCB1), are associated to differences in pharmacokinetics. The three antipsychotics act on dopamine and serotonin receptors, among others, and several studies found associations between polymorphisms in these genes and variations in the incidence of adverse effects and in the response to the drug. Since olanzapine is metabolized by CYP1A2, a lower starting dose should be considered in patients treated with fluvoxamine or other CYP1A2 inhibitors. Regarding aripiprazole, a reduced dose should be administered in CYP2D6 poor metabolizers (PMs). Additionally, a reduction to a quarter of the normal dose is recommended if the patient is treated with concomitant CYP3A4 inhibitors. Risperidone dosage should be reduced for CYP2D6 PMs and titrated for CYPD6 ultrarapid metabolizers (UMs). Moreover, risperidone dose should be evaluated when a CYP2D6, CYP3A4 or ABCB1 inhibitor is administered concomitantly.
C1 [Soria-Chacartegui, Paula; Villapalos-Garcia, Gonzalo; Zubiaur, Pablo; Abad-Santos, Francisco] Univ Autonoma Madrid, Inst Invest Sanitaria La Princesa IP, Hosp Univ La Princesa, Clin Pharmacol Dept,Sch Med,Inst Teofilo Hernando, Madrid, Spain.
   [Zubiaur, Pablo; Abad-Santos, Francisco] UICEC Hosp Univ La Princesa, Platform SCReN Spanish Clin Res Network, Inst Invest Sanitaria La Princesa IP, Madrid, Spain.
   [Abad-Santos, Francisco] Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Hepat & Digest, Madrid, Spain.
   [Koller, Dora] Yale Sch Med, Dept Psychiat, West Haven, CT USA.
   [Koller, Dora] VA CT Healthcare Ctr, West Haven, CT USA.
C3 Autonomous University of Madrid; Hospital de La Princesa; Instituto de
   Salud Carlos III; CIBER - Centro de Investigacion Biomedica en Red;
   CIBEREHD; Yale University
RP Abad-Santos, F (corresponding author), Univ Autonoma Madrid, Inst Invest Sanitaria La Princesa IP, Hosp Univ La Princesa, Clin Pharmacol Dept,Sch Med,Inst Teofilo Hernando, Madrid, Spain.; Abad-Santos, F (corresponding author), UICEC Hosp Univ La Princesa, Platform SCReN Spanish Clin Res Network, Inst Invest Sanitaria La Princesa IP, Madrid, Spain.; Abad-Santos, F (corresponding author), Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Hepat & Digest, Madrid, Spain.; Koller, D (corresponding author), Yale Sch Med, Dept Psychiat, West Haven, CT USA.; Koller, D (corresponding author), VA CT Healthcare Ctr, West Haven, CT USA.
EM francisco.abad@uam.es; dora.koller@yale.edu
RI Zubiaur, Pablo/AAC-3959-2022; Koller, Dora/JOK-2364-2023; Abad-Santos,
   Francisco/J-7115-2013; Garcia, Gonzalo/AAK-4488-2021
OI Villapalos Garcia, Gonzalo/0000-0002-4849-3268; Soria Chacartegui,
   Paula/0000-0002-1951-2626; Zubiaur, Pablo/0000-0002-6150-4320
FU Instituto de Salud Carlos III (ISCIII); European Social Fund
   [FI20/00090]; scholarship "Ayuda para el fomento de la investigacion en
   estudios de master 2020" - Universidad Autonoma de Madrid
FX GV-G is financed by Instituto de Salud Carlos III (ISCIII) and the
   European Social Fund (PFIS predoctoral grant, number FI20/00090). PS-C
   is financed by the scholarship "Ayuda para el fomento de la
   investigacion en estudios de master 2020" granted by Universidad
   Autonoma de Madrid.
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NR 131
TC 33
Z9 34
U1 0
U2 21
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD JUL 14
PY 2021
VL 12
AR 711940
DI 10.3389/fphar.2021.711940
PG 16
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA TR6WU
UT WOS:000679103900001
PM 34335273
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Midttun, M
   Overgaard, K
   Rasmussen, RS
AF Midttun, Mette
   Overgaard, Karsten
   Rasmussen, Rune Skovgaard
TI Testosterone serum levels in elderly fall-prone do not correlate with
   age or performance in the 30 seconds chair stand test
SO JOURNAL OF GERONTOLOGY AND GERIATRICS
LA English
DT Article
DE nutrition; metabolism
ID PHYSICAL FUNCTION; ASSOCIATION; STRENGTH
AB Background & aims. Multiple studies have shown associations between low testosterone, declining physical function and cognition, metabolic syndrome, depression, falls, and even mortality, and the benefits of reestablishing the level of testosterone in elderly men with deficiency. The purpose of the study was to decide who of such men might benefit from further geriatric assessment, intervention by training, testosterone injections, and how to get in touch with these gentlemen.
   Method. Testosterone was measured in men above 70 years old who experienced a decline in safety of mobility. Participants were recruited through advertisements in local newspapers. Men who walk unsteadily, are about to fall or have been falling, who experience that they are getting weaker or have deteriorated physical health, were questioned about symptoms and diseases, supplied with total testosterone measurements and a 30 seconds chair stand test.
   Results. 177 men were screened. Mean age 77.7 (70-95). Total testosterone mean value = 12.1 (4.3-17.0 nmol/l). Chair stand tests did not correlate with testosterone levels, p = 0.98, neither did testosterone levels correlate with age, p = 0.65, (Spearman).
   Conclusions. The important fact is that the gentlemen themselves experience a physical decline confirmed through a thorough conversation. We still do not know for sure how to identify men who might profit from further examination but a testosterone blood test and a chair stand test in men above 70 years old who experience increasing frailty will be a start.
C1 [Midttun, Mette; Overgaard, Karsten; Rasmussen, Rune Skovgaard] Copenhagen Univ Hosp Herlev, Dept Geriatr, Herlev, Denmark.
C3 University of Copenhagen; Copenhagen University Hospital
RP Midttun, M (corresponding author), Copenhagen Univ Hosp Herlev, Dept Geriatr, Herlev, Denmark.
EM info@mettemidttun.dk
OI Midttun, Mette/0000-0003-0293-3456
FU Helsefonden; Marie og Borge Kroghs Fond; Beckett Foundation; Any and
   Richard Sperling Foundation; Fondation Juchum; Velux Foundation
FX The investigation was funded by Helsefonden, Marie og Borge Kroghs Fond,
   The Beckett Foundation, Any and Richard Sperling Foundation, Fondation
   Juchum, and the Velux Foundation. Besides providing funding, no source
   of funding had any involvement in the investigation.
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NR 17
TC 0
Z9 0
U1 0
U2 2
PU PACINI EDITORE
PI PISA
PA VIA DELLA GHERARDESCA-ZONA INDUSTRIALE OSPEDALETTO, 56121 PISA, ITALY
SN 2499-6564
J9 J GERONTOL GERIATR
JI J. Gerontol. Geriatr.
PD JUN
PY 2021
VL 69
IS 2
BP 98
EP 102
DI 10.36150/2499-6564-N285
PG 5
WC Gerontology
WE Emerging Sources Citation Index (ESCI)
SC Geriatrics & Gerontology
GA XQ8DD
UT WOS:000731772200002
OA hybrid
DA 2025-06-11
ER

PT J
AU Bouman, EJ
   Slebe, R
   Stenvers, DJ
   Elders, PJM
   Beulens, JWJ
   Rutters, F
AF Bouman, Emma J.
   Slebe, Romy
   Stenvers, Dirk Jan
   Elders, Petra J. M.
   Beulens, Joline W. J.
   Rutters, Femke
TI A randomized controlled trial to assess if changing sleep timing can
   improve glucose metabolism in people with prediabetes and type 2
   diabetes
SO TRIALS
LA English
DT Article
DE Social jetlag; Circadian rhythm; Type 2 diabetes mellitus; Glycemic
   control; Metabolic control; Randomized controlled trial
ID SOCIAL JETLAG; LIGHT; SUPPORT
AB BackgroundSocial jetlag is a chronic disruption of sleep timing that is characterized by different sleep timing during workdays and free days. Social jetlag has been associated with disturbed glucose metabolism, insulin resistance, and increased risk of metabolic syndrome and type 2 diabetes. In this study, we aim to investigate whether a combination of bright light therapy in the morning, bright light reduction in the evening and sleep advance instructions for 3 weeks reduces social jetlag and if this results in improvement of glycemic and metabolic control, sleep, mood and quality of life after 3 and 12 weeks in people with prediabetes and type 2 diabetes and to assess possible mediators, compared to regular sleep habits. MethodsIn this randomized controlled trial, 60 people with prediabetes or type 2 diabetes with > 1 h social jetlag will be recruited. The intervention consists of bright light therapy (5000 lx) emitted by Vitamine-L (Lumie, UK) for 30 min each morning, combined with the advice to follow sleep advance instructions and to wear bright light-dimming goggles every evening for a period of 3 weeks. The control group adheres to their regular sleep habits and conditions. The primary outcome is glycated hemoglobin (HbA1c) after 12 weeks comparing the intervention and control in an intention-to-treat analysis. Secondary outcomes at 3 and 12 weeks are (1) social jetlag; (2) insulin sensitivity, fasting blood glucose, glucose-lowering medication use, and frequency of perceived hypoglycemia; (3) metabolic outcomes, including body mass index (BMI), waist circumference, body fat percentage, and blood pressure; (4) mood, including depression, fatigue and anxiety (measured with questionnaires); and (5) quality of life measured using EQ5D questionnaire. To assess other factors that might play a role as possible mediators, we will measure (para)sympathetic nervous system activity assessed with ECGs and electrochemical skin conductance tests, sleep quality and sleep phase distribution assessed with a sleep measuring headband (ZMax), the Dim Light Melatonin Onset in saliva samples (in a subgroup) at 3 and 12 weeks, the feeling of satiety and satiation with a 10-cm visual analog scale (VAS), diet using a food frequency questionnaire, and physical activity using an accelerometer (ActiGraph). DiscussionSocial jetlag can contribute to poorer glycemic control and metabolic control in those with type 2 diabetes. With this intervention, we aim to reduce social jetlag and thereby improve glycemic and metabolic control. This could offer a way to improve overall population health and to reduce the disease burden of type 2 diabetes. Trial registrationISRCTN registry ISRCTN11967109. Registered on 9 May 2024.
C1 [Bouman, Emma J.; Slebe, Romy; Beulens, Joline W. J.; Rutters, Femke] Amsterdam UMC locat Vrije Univ Amsterdam, Epidemiol & Data Sci, Meibergdreef 9, Amsterdam, Netherlands.
   [Bouman, Emma J.; Slebe, Romy; Elders, Petra J. M.; Beulens, Joline W. J.; Rutters, Femke] Amsterdam Publ Hlth Hlth Behav & Chron Dis, Amsterdam, Netherlands.
   [Stenvers, Dirk Jan] Amsterdam UMC locat Univ Amsterdam, Endocrinol & Metab, Meibergdreef 9, Amsterdam, Netherlands.
   [Stenvers, Dirk Jan] Amsterdam Gastoenterol, Endocrinol Metab, Amsterdam, Netherlands.
   [Stenvers, Dirk Jan] Amsterdam UMC locat Vrije Univ Amsterdam, Endocrinol & Metab, Meibergdreef 9, Amsterdam, Netherlands.
   [Elders, Petra J. M.] Amsterdam UMC locat Vrije Univ Amsterdam, Gen Practice, Meibergdreef 9, Amsterdam, Netherlands.
RP Bouman, EJ (corresponding author), Amsterdam UMC locat Vrije Univ Amsterdam, Epidemiol & Data Sci, Meibergdreef 9, Amsterdam, Netherlands.; Bouman, EJ (corresponding author), Amsterdam Publ Hlth Hlth Behav & Chron Dis, Amsterdam, Netherlands.
EM e.bouman1@amsterdamumc.nl
OI Bouman, Emma Jantine/0000-0001-6559-8961
FU Diabetes Fonds
FX No Statement Available
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NR 25
TC 0
Z9 0
U1 1
U2 3
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1745-6215
J9 TRIALS
JI Trials
PD JUL 12
PY 2024
VL 25
IS 1
AR 474
DI 10.1186/s13063-024-08329-w
PG 10
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA YW1Y6
UT WOS:001271442200003
PM 38997765
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Strzelecki, D
   Kaluzynska, O
   Szyburska, J
   Wysokinski, A
AF Strzelecki, Dominik
   Kaluzynska, Olga
   Szyburska, Justyna
   Wysokinski, Adam
TI MMP-9 Serum Levels in Schizophrenic Patients during Treatment
   Augmentation with Sarcosine (Results of the PULSAR Study)
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE matrix metallopeptidase-9 (MMP-9); sarcosine; NMDA
   (N-methyl-d-aspartate) receptor; glutamatergic system; schizophrenia;
   negative symptoms
ID LONG-TERM POTENTIATION; TREATMENT-RESISTANT SCHIZOPHRENIA; MATRIX
   METALLOPROTEINASES; MATRIX-METALLOPROTEINASE-9 MMP-9; NEUROTROPHIC
   FACTOR; METABOLIC SYNDROME; BRAIN; DISORDERS; CLOZAPINE; METAANALYSIS
AB Aim: Find changes in matrix metallopeptidase-9 (MMP-9) levels during augmentation of antipsychotic treatment with sarcosine and a relationship between schizophrenia symptoms severity and initial level of MMP-9. Method: Fifty-eight patients with diagnosis of schizophrenia with predominant negative symptoms participated in a six-month prospective RCT (randomized controlled trial). The patients received two grams of sarcosine (n = 28) or placebo (n = 30) daily. At the beginning, after six weeks and after six months MMP-9 levels were measured. Severity of symptomatology was assessed with the Positive and Negative Syndrome Scale (PANSS) and Calgary Depression Scale for Schizophrenia (CDSS). Results: MMP-9 serum levels were stable after six weeks and six months in both groups. We noted improvement in negative symptoms, general psychopathology and total PANSS score in sarcosine group compared to placebo; however, there was no correlations between serum MMP-9 concentrations and PANSS scores in all assessments. Initial serum MMP-9 concentrations cannot be used as an improvement predictor acquired during sarcosine augmentation. Conclusions: Our results indicate that either MMP-9 is not involved in the N-methyl-d-aspartate (NMDA)-dependent mechanism of sarcosine action in terms of clinical parameters or sarcosine induced changes in peripheral MMP-9 concentrations cannot be detected in blood assessments.
C1 [Strzelecki, Dominik; Kaluzynska, Olga; Szyburska, Justyna] Med Univ Lodz, Dept Affect & Psychot Disorders, Cent Clin Hosp, Czechoslowacka 8-10, PL-92216 Lodz, Poland.
   [Wysokinski, Adam] Med Univ Lodz, Dept Old Age Psychiat & Psychot Disorders, Cent Clin Hosp, Czechoslowacka 8-10, PL-92216 Lodz, Poland.
C3 Medical University Lodz; Medical University Lodz
RP Strzelecki, D (corresponding author), Med Univ Lodz, Dept Affect & Psychot Disorders, Cent Clin Hosp, Czechoslowacka 8-10, PL-92216 Lodz, Poland.
EM dominik.strzelecki@umed.lodz.pl; okaluzynska@gmail.com;
   szyburska@gmail.com; adam.wysokinski@gmail.com
RI Wysokinski, Adam/S-9294-2016; Strzelecki, Dominik/S-9340-2016;
   Wysokinski, Adam/G-8174-2014
OI Strzelecki, Dominik/0000-0002-8559-1078; Kaluzynska,
   Olga/0000-0002-3404-2095; Wysokinski, Adam/0000-0002-6159-6579
FU Polish Ministry of Science and Higher Education [N402 268836]; Healthy
   Ageing Research Centre [REGPOT-2012-2013-1, 7FP]
FX Bioethics Committee of the Medical University of Lodz approved the study
   protocol (permission number and date: RNN/153/08/KE, 15 July 2008).
   Polish Sarcosine Study in Schizophrenia (PULSAR) was supported by the
   grant of Polish Ministry of Science and Higher Education (N402 268836).
   Our study is also registered on ClinicalTrials.gov site, study
   identifier: NCT01503359. The authors are partially supported by Healthy
   Ageing Research Centre (REGPOT-2012-2013-1, 7FP).
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NR 45
TC 10
Z9 10
U1 0
U2 3
PU MDPI AG
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD JUL
PY 2016
VL 17
IS 7
AR 1075
DI 10.3390/ijms17071075
PG 11
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA DT5DK
UT WOS:000381500900090
PM 27409603
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Chiu, HY
   Wang, TS
   Chen, PH
   Hsu, SH
   Tsai, YC
   Tsai, TF
AF Chiu, Hsien-Yi
   Wang, Ting-Shun
   Chen, Po-Hua
   Hsu, Shao-Hsuan
   Tsai, Ya-Chu
   Tsai, Tsen-Fang
TI Psoriasis in Taiwan: From epidemiology to new treatments
SO DERMATOLOGICA SINICA
LA English
DT Review
DE Psoriasis; Epidemiology; Comorbidity; Biologics; Interleukin-17a
   inhibitor; Interleukin-23 inhibitor
ID SEVERE PLAQUE PSORIASIS; QUALITY-OF-LIFE; PLACEBO-CONTROLLED TRIAL;
   TO-SEVERE PSORIASIS; INTERLEUKIN-12/23 MONOCLONAL-ANTIBODY; OBSTRUCTIVE
   SLEEP-APNEA; CHRONIC KIDNEY-DISEASE; INCREASED RISK; PHASE-III; CHINESE
   PATIENTS
AB Psoriasis is a common, chronic immune-mediated disorder that occurs worldwide. The prevalence of psoriasis in Taiwan is lower than that in Caucasian countries. Nevertheless, an increasing trend in the prevalence of psoriasis and psoriatic arthritis has been observed in Taiwan over the past decade. Accumulating studies have also suggested that psoriasis is not a disease limited to the skin and joints but has far-reaching systemic effects, associated with a higher prevalence of comorbid diseases, such as cardiovascular diseases, diabetes mellitus, metabolic syndrome, depression, and chronic kidney disease, than in the normal population. To date, our understanding of the mechanisms linking psoriasis and comorbidities remains far from complete. Psoriasis and its comorbid diseases confer substantial disease and health care burdens and have a significant negative impact on the quality of life of affected patients. The discovery of new, promising drugs has revolutionized psoriasis treatment, but patients still have unmet needs that require further investigation. Studies specifically on the Taiwanese population with psoriasis remain scarce. Herein, we review the medical literature, with a focus on studies examining the Taiwanese population, with regard to epidemiology, comorbidities, and effects of antipsoriatic agents on comorbidities, as well as the efficacy and safety of novel antipsoriatic treatments for patients with psoriasis. Copyright (C) 2018, Taiwanese Dermatological Association. Published by Elsevier Taiwan LLC.
C1 [Chiu, Hsien-Yi] Natl Taiwan Univ Hosp, Hsin Chu Branch, Dept Dermatol, Hsinchu, Taiwan.
   [Chiu, Hsien-Yi] Natl Taiwan Univ, Coll Med, Inst Biomed Engn, Taipei, Taiwan.
   [Chiu, Hsien-Yi] Natl Taiwan Univ, Coll Engn, Taipei, Taiwan.
   [Chiu, Hsien-Yi; Wang, Ting-Shun; Chen, Po-Hua; Hsu, Shao-Hsuan; Tsai, Tsen-Fang] Natl Taiwan Univ Hosp, Dept Dermatol, 7 Chung San South Rd, Taipei, Taiwan.
   [Chiu, Hsien-Yi; Wang, Ting-Shun; Chen, Po-Hua; Hsu, Shao-Hsuan; Tsai, Tsen-Fang] Natl Taiwan Univ, Coll Med, Dept Dermatol, Taipei, Taiwan.
   [Wang, Ting-Shun] Chung Shan Med Univ Hosp, Dept Dermatol, Taichung, Taiwan.
   [Wang, Ting-Shun] Chung Shan Med Univ, Dept Dermatol, Taichung, Taiwan.
   [Chen, Po-Hua; Hsu, Shao-Hsuan] Natl Taiwan Univ Hosp, Yun Lin Branch, Dept Dermatol, Taipei, Yunlin, Taiwan.
   [Tsai, Ya-Chu] Far Eastern Mem Hosp, Dept Dermatol, New Taipei, Taiwan.
C3 National Taiwan University; National Taiwan University Hospital;
   National Taiwan University; National Taiwan University; National Taiwan
   University; National Taiwan University Hospital; National Taiwan
   University; Chung Shan Medical University; Chung Shan Medical University
   Hospital; Chung Shan Medical University; National Taiwan University;
   National Taiwan University Hospital; Far Eastern Memorial Hospital
RP Tsai, TF (corresponding author), Natl Taiwan Univ Hosp, Dept Dermatol, 7 Chung San South Rd, Taipei, Taiwan.
EM tftsai@yahoo.com
OI HSU, SHAO-HSUAN/0000-0003-1820-9905; Chiu, Hsien-Yi/0000-0002-0493-9707;
   TSAI, TSEN-FANG/0000-0002-1498-1474
FU National Taiwan University Hospital, Hsin-Chu branch [HCH 106-HCH055,
   107-HCH057]; Asia-Pacific La Roche-Posay Foundation
FX This work was supported in part by grants from the National Taiwan
   University Hospital, Hsin-Chu branch [HCH 106-HCH055 and 107-HCH057],
   and in part by the Basic Research Award, Asia-Pacific La Roche-Posay
   Foundation 2014. The funders had no role in the study design, data
   collection and analysis, interpretation of findings, manuscript writing,
   or target journal selection.
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NR 144
TC 41
Z9 40
U1 1
U2 12
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, 400059, INDIA
SN 1027-8117
EI 2223-330X
J9 DERMATOL SIN
JI Dermatol. Sin.
PD SEP
PY 2018
VL 36
IS 3
BP 115
EP 123
DI 10.1016/j.dsi.2018.06.001
PG 9
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA GR2PN
UT WOS:000442419200001
OA gold
DA 2025-06-11
ER

PT J
AU Biedermann, L
   Rogler, G
AF Biedermann, Luc
   Rogler, Gerhard
TI The intestinal microbiota: its role in health and disease
SO EUROPEAN JOURNAL OF PEDIATRICS
LA English
DT Review
DE Bacterial flora; Intestine; Microbiota; Fecal microbiota
   transplantation; Dysbiosis; Inflammatory bowel disease; Metabolic
   diseases
ID INFLAMMATORY-BOWEL-DISEASE; HUMAN GUT MICROBIOME; CULTURE-INDEPENDENT
   ANALYSIS; SEROVAR TYPHIMURIUM COLITIS; EPITHELIAL BARRIER FUNCTION;
   CROHNS-DISEASE; FECAL MICROBIOTA; ESCHERICHIA-COLI; ULCERATIVE-COLITIS;
   MOUSE MODEL
AB The intestinal microbiota (previously referred to as "intestinal flora") has entered the focus of research interest not only in microbiology but also in medicine. Huge progress has been made with respect to the analysis of composition and functions of the human microbiota. An "imbalance" of the microbiota, frequently also called a "dysbiosis," has been associated with different diseases in recent years. Crohn's disease and ulcerative colitis as two major forms of inflammatory bowel disease, irritable bowel syndrome (IBS) and some infectious intestinal diseases such as Clostridium difficile colitis feature a dysbiosis of the intestinal flora. Whereas this is somehow expected or less surprising, an imbalance of the microbiota or an enrichment of specific bacterial strains in the flora has been associated with an increasing number of other diseases such as diabetes, metabolic syndrome, non-alcoholic fatty liver disease or steatohepatitis and even psychiatric disorders such as depression or multiple sclerosis. It is important to understand the different aspects of potential contributions of the microbiota to pathophysiology of the mentioned diseases.
   Conclusion: With the present manuscript, we aim to summarize the current knowledge and provide an overview of the different concepts on how bacteria contribute to health and disease in animal models and-more importantly-humans. In addition, it has to be borne in mind that we are only at the very beginning to understand the complex mechanisms of host-microbial interactions.
C1 [Biedermann, Luc; Rogler, Gerhard] Univ Zurich Hosp, Div Gastroenterol & Hepatol, CH-8091 Zurich, Switzerland.
   [Rogler, Gerhard] Univ Zurich, Zurich Ctr Integrat Human Physiol, Zurich, Switzerland.
C3 University of Zurich; University Zurich Hospital; University of Zurich;
   Zurich Center Integrative Human Physiology (ZIHP)
RP Rogler, G (corresponding author), Univ Zurich Hosp, Div Gastroenterol & Hepatol, Ramistr 100, CH-8091 Zurich, Switzerland.
EM luc.biedermann@usz.ch; gerhard.rogler@usz.ch
RI Biedermann, Luc/J-2654-2017; Rogler, Gerhard/O-5308-2015
OI Rogler, Gerhard/0000-0002-1733-9188
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NR 215
TC 148
Z9 179
U1 2
U2 271
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0340-6199
EI 1432-1076
J9 EUR J PEDIATR
JI Eur. J. Pediatr.
PD FEB
PY 2015
VL 174
IS 2
BP 151
EP 167
DI 10.1007/s00431-014-2476-2
PG 17
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA AZ4SJ
UT WOS:000348212700002
PM 25563215
DA 2025-06-11
ER

PT J
AU Madan, A
   Clapp, J
   Osborne, P
   Walker, C
   Frueh, BC
   Allen, J
   Oldham, J
   Fowler, JC
AF Madan, Alok
   Clapp, Joshua
   Osborne, Patricia
   Walker, Cory
   Frueh, B. Christopher
   Allen, Jon
   Oldham, John
   Fowler, J. Christopher
TI Improvements in Somatic Complaints Among Individuals With Serious Mental
   Illness Receiving Treatment in a Psychiatric Hospital
SO PSYCHOSOMATIC MEDICINE
LA English
DT Article
DE somatic complaints; serious mental illness; inpatient treatment;
   hospitalized patients; clinical outcomes
ID QUALITY-OF-LIFE; SCHIZOAFFECTIVE DISORDER; MEDICAL COMORBIDITY;
   METABOLIC SYNDROME; SUICIDAL THOUGHTS; PHYSICAL ILLNESS; PAIN
   CONDITIONS; SLEEP PROBLEMS; PRIMARY-CARE; HEALTH-CARE
AB Objective: Individuals with serious mental illness (SMI) experience significant comorbid somatic complaints. Little is known about response to integrated inpatient care that addresses psychiatric and general medical needs among individuals with SMI.
   Methods: Latent growth curve analyses were used to model somatic symptom trajectories across adult inpatients with SMI (n = 989). The Patient Health Questionnaire-15 (PHQ-15) was administered at admission, every 14 days, and at discharge.
   Results: Patients evidenced substantial reduction in somatization from admission (mean [standard deviation] = 9.0 [5.2]) to discharge (mean [standard deviation] = 5.2 [4.4]), with large effects (d = 0.83, 95% confidence interval = 0.76-0.90). Results indicate nonlinear improvement in somatic symptoms for 8 weeks of treatment, with greatest symptom reduction occurring during the first weeks of treatment with continued, albeit slowed, improvement until discharge. Initial PHQ-15 scores were lower among men and those who reported regular exercise in the 30 days preceding this hospitalization. In addition, presence of an anxiety disorder or personality disorder at admission; history of trauma, a gastrointestinal disorder, or major medical illness (within the past 3 months); and significant sleep disturbance independently contribute to higher PHQ-15 scores at admission. A substance use disorder and sleep disturbance were associated with greater immediate symptom reduction.
   Conclusions: Somatic complaints can be managed in the context of inpatient psychiatric care integrated with 24-hour nursing and internal medicine specialists. Addressing psychiatric impairments, improving sleep, and ensuring abstinence from drugs and alcohol are associated with significant improvement in somatic complaints.
C1 [Madan, Alok; Osborne, Patricia; Walker, Cory; Frueh, B. Christopher; Allen, Jon; Oldham, John; Fowler, J. Christopher] Menninger Clin, 12301 South Main St, Houston, TX 77035 USA.
   [Madan, Alok; Walker, Cory; Allen, Jon; Oldham, John; Fowler, J. Christopher] Baylor Coll Med, Menninger Dept Psychiat & Behav Sci, Houston, TX 77030 USA.
   [Clapp, Joshua] Univ Wyoming, Dept Psychol, Laramie, WY 82071 USA.
   [Frueh, B. Christopher] Univ Hawaii, Dept Psychol, Hilo, HI 96720 USA.
C3 Baylor College of Medicine; University of Wyoming; University of Hawaii
   System; University Hawaii Hilo
RP Madan, A (corresponding author), Menninger Clin, 12301 South Main St, Houston, TX 77035 USA.
EM amadan@menninger.edu
OI Clapp, Joshua/0000-0003-2897-5363
FU Menninger Clinic Foundation; McNair Medical Institute
FX This research was partially supported by the Menninger Clinic Foundation
   and McNair Medical Institute. Drs. Frueh and Madan are McNair Scholars.
   The authors have no other conflicts of interest to report.
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NR 83
TC 19
Z9 19
U1 0
U2 15
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0033-3174
EI 1534-7796
J9 PSYCHOSOM MED
JI Psychosom. Med.
PD APR
PY 2016
VL 78
IS 3
BP 271
EP 280
DI 10.1097/PSY.0000000000000298
PG 10
WC Psychiatry; Psychology; Psychology, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry; Psychology
GA DJ1FY
UT WOS:000373949900003
PM 26867074
DA 2025-06-11
ER

PT J
AU Karukivi, M
   Jula, A
   Pulkki-Råback, L
   Hutri-Kähönen, N
   Laitinen, TT
   Viikari, J
   Juonala, M
   Raitakari, O
AF Karukivi, Max
   Jula, Antti
   Pulkki-Raback, Laura
   Hutri-Kahonen, Nina
   Laitinen, Tomi T.
   Viikari, Jorma
   Juonala, Markus
   Raitakari, Olli
TI Ideal cardiovascular health in adolescents and young adults is
   associated with alexithymia over two decades later: Findings from the
   cardiovascular risk in Young Finns Study Department: Research Centre of
   Applied and Preventive Cardiovascular Medicine, University of Turku,
   Turku, Finland
SO PSYCHIATRY RESEARCH
LA English
DT Article
DE Diet; Emotions; Ideal cardiovascular health index; Lifestyle habits
ID INTEROCEPTIVE AWARENESS; FACTORIAL VALIDITY; METABOLIC SYNDROME;
   LIFE-STYLE; SCALE; PERSONALITY; PREVALENCE; RELIABILITY; VALIDATION;
   DISORDERS
AB We evaluated the association of cardiovascular health in adolescence and young adulthood with alexithymia 25 years later. The study sample (n = 1122) participated in evaluations conducted in 1986 (baseline) and in 2011-2012 (T2). Baseline health factors and behaviors were assessed utilizing seven ideal cardiovascular health metrics (ICH index) including blood pressure, cholesterol and glucose levels, smoking, physical activity, body-mass-index, and diet. The stability of the ICH index was evaluated with corresponding assessments in 2007 (T1). At T2, alexithymia was measured with the 20-item Toronto Alexithymia Scale (TAS-20). The main analyses were conducted using ANCOVA and adjusted for depression, age, and present social and lifestyle factors. TAS-20 subscales, Difficulty Identifying Feelings (DIF), Difficulty Describing Feelings (DDF), and Externally Oriented Thinking, were analyzed separately. The ICH index was significantly associated with the TAS-20 total score, as well as both with DIF and DDF. A less ideal cardiovascular health was associated with higher alexithymia scores. However, regarding the separate factors, only the association between non-ideal dietary habits and DIF was significant in the multivariate analyses. The baseline ICH index score was stable from baseline to T1. We conclude that non-ideal cardiovascular lifestyle habits in adolescence and young adulthood are significantly associated with later alexithymia.
C1 [Karukivi, Max] Univ Turku, Dept Psychiat, Kunnallissairaalantie 20, FI-20700 Turku, Finland.
   [Karukivi, Max; Raitakari, Olli] Turku Univ Hosp, Turku, Finland.
   [Karukivi, Max] Satakunta Hosp Dist, Dept Adolescent Psychiat, Pori, Finland.
   [Jula, Antti] Natl Inst Hlth & Welf, Dept Publ Hlth Solut, Helsinki, Finland.
   [Pulkki-Raback, Laura] Univ Helsinki, Fac Med, Depcutment Psychol & Logoped, Helsinki, Finland.
   [Pulkki-Raback, Laura] Univ Turku, Res Ctr Child Psychiat, Turku, Finland.
   [Hutri-Kahonen, Nina] Univ Tampere, Dept Pediat, Tampere, Finland.
   [Laitinen, Tomi T.; Raitakari, Olli] Univ Turku, Res Ctr Appl & Prevent Cardiovasc Med, Turku, Finland.
   [Laitinen, Tomi T.] Univ Turku, Dept Phys Act & Hlth, Paavo Nurmi Ctr, Sports & Exercise Med Unit, Turku, Finland.
   [Viikari, Jorma; Juonala, Markus] Univ Turku, Dept Med, Turku, Finland.
   [Viikari, Jorma; Juonala, Markus] Turku Univ Hosp, Div Med, Turku, Finland.
   [Juonala, Markus] Murdoch Childrens Res Inst, Parkville, Vic, Australia.
   [Raitakari, Olli] Univ Turku, Ctr Populat Hlth Res, Turku, Finland.
   [Raitakari, Olli] Turku Univ Hosp, Dept Clin Physiol & Nucl Med, Turku, Finland.
C3 University of Turku; University of Turku; Finland National Institute for
   Health & Welfare; University of Helsinki; University of Turku; Tampere
   University; University of Turku; University of Turku; University of
   Turku; University of Turku; Murdoch Children's Research Institute;
   University of Turku; University of Turku
RP Karukivi, M (corresponding author), Univ Turku, Dept Psychiat, Kunnallissairaalantie 20, FI-20700 Turku, Finland.
EM max.karukivi@utu.fi
RI Raitakari, Olli/AAQ-7389-2021
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NR 48
TC 1
Z9 1
U1 0
U2 6
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0165-1781
J9 PSYCHIAT RES
JI Psychiatry Res.
PD JUL
PY 2020
VL 289
AR 112976
DI 10.1016/j.psychres.2020.112976
PG 8
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA MY4XV
UT WOS:000558423200001
PM 32413709
DA 2025-06-11
ER

PT J
AU Brandacher, G
   Hoeller, E
   Fuchs, D
   Weiss, HG
AF Brandacher, G.
   Hoeller, E.
   Fuchs, D.
   Weiss, Helmut G.
TI Chronic immune activation underlies morbid obesity: Is IDO a key player?
SO CURRENT DRUG METABOLISM
LA English
DT Review
DE morbid obesity; indoleamine2,3-dioxygenase; chronic immune activation;
   serotonin
ID C-REACTIVE PROTEIN; TRYPTOPHAN DEPLETION; INTERFERON-GAMMA; INDOLEAMINE
   2,3-DIOXYGENASE; INCREASED DEGRADATION; CHRONIC INFLAMMATION; METABOLIC
   SYNDROME; FOOD RESTRICTION; TNF-ALPHA; BODY-MASS
AB Morbid obesity is associated with low-grade systemic inflammation and immune activation. Thereby various proinflammatory cytokines like TNF-alpha, IL-1, IL-6, IFN-gamma and hormones, such as leptin are synthesized and released in human adipose tissue The immunomodulatory enzyme indoleamine 2,3-dioxygenase (IDO) is widely distributed in mammals and is inducible preferentially by IFN-gamma. IDO degrades the essential amino acid tryptophan to form N-formyl kynurenine which, depending on cell type and enzymatic repertoires, is subsequently converted to finally form niacin. More recently, it has been proposed that activation of IDO is also critically involved in the regulation of immune responses. In obesity plasma tryptophan concentrations have been shown to be decreased and to be independent of weight reduction or dietary intake. In addition, we previously demonstrated that IDO mediated tryptophan catabolism due to chronic immune activation is the cause for such reduced tryptophan plasma levels in morbidly obese patients compared to lean individuals. Furthermore, these tryptophan metabolic changes may subsequently reduce serotonin production and cause mood disturbances, depression, and impaired satiety ultimately leading to increased caloric uptake and obesity. IDO-mediated tryptophan degradation due to chronic immune activation can therefore be considered as the driving force for food intake. We here review the potential pathogenic links between chronic immune activation and decreased IDO mediated tryptophan and serotonin levels in morbid obesity.
C1 Innsbruck Med Univ, Dept Gen & Transplant Surg, D Swarovski Res Lab, A-6020 Innsbruck, Austria.
   Innsbruck Med Univ, Div Biol Chem, Bioctr, Innsbruck, Austria.
   Ludwig Boltzmann Inst AIDS Res, Innsbruck, Austria.
C3 Medical University of Innsbruck; Medical University of Innsbruck; Ludwig
   Boltzmann Institute; Ludwig Boltzmann Institute for AIDS Research
RP Weiss, HG (corresponding author), Innsbruck Med Univ, Dept Gen & Transplant Surg, D Swarovski Res Lab, Anichstr 35, A-6020 Innsbruck, Austria.
EM helmut.weiss@uki.at
RI Fuchs, Dietmar/AAL-8011-2021; Brandacher, Gerald/L-7540-2016
OI Brandacher, Gerald/0000-0001-7790-441X
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NR 70
TC 87
Z9 89
U1 0
U2 12
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1389-2002
EI 1875-5453
J9 CURR DRUG METAB
JI Curr. Drug Metab.
PD APR
PY 2007
VL 8
IS 3
BP 289
EP 295
DI 10.2174/138920007780362590
PG 7
WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
GA 158EJ
UT WOS:000245773700013
PM 17430117
DA 2025-06-11
ER

PT J
AU Neagos, A
   Costache, A
   Gheorghe, D
   Georgescu, M
   Necula, V
   Martu, C
   Paduraru, L
   Budacu, C
   Olariu, R
   Vrinceanu, D
   Hinganu, D
   Cozma, S
AF Neagos, Adriana
   Costache, Adrian
   Gheorghe, Dan
   Georgescu, Madalina
   Necula, Violeta
   Martu, Cristian
   Paduraru, Luminita
   Budacu, Cristian
   Olariu, Raluca
   Vrinceanu, Daniela
   Hinganu, Delia
   Cozma, Sebastian
TI Sleep Disturbances and Their Impact on Socio-Professional Capacities in
   Patients with Obstructive Sleep Apnea
SO REVISTA DE CERCETARE SI INTERVENTIE SOCIALA
LA English
DT Article
DE obstructive sleep apnea; sleep quality; polysomnography;
   socio-professional life; Pittsburgh Sleep Quality Self-Assessment
   Questionnaire; social impact
ID QUALITY-OF-LIFE; INDEX; DEPRESSION; DISORDERS
AB As a prominent problem in the modern society and showing an increasing prevalence, sleep disorders including frequently obstructive sleep apnea (OSA) raises the issue of the multiple health and socio-professional debilitating effect. This study aimed to assess by Pittsburgh Sleep Quality Index (PSQI) questionnaire the sleep disturbances and their impact on socio-professional capacities in patients with OSA. We evaluated through the PSQI a group of 144 patients with suspected sleep disorders, whom 22 were diagnosed with OSA by polysomnography. For OSA patients, we analyzed the associated comorbidities and the characteristics of sleep disturbances and their influence on quality of socio-professional life. The main associated comorbidities to our OSA patients were the hypertension (90.90%), the type II diabetes (40.91%) and the metabolic syndrome (31.83%). We found that the most important sleep disturbances that affected the quality of life are the sleep interruptions, the waking up too early, the late falling asleep and snoring. The most significant problems induced by sleep disorders were communication problems and concentration disorders, with more than three times a week for at least 36.36% of patients. The work capacity was affected at least once a month in 77,27% of OSA patients, 40,91% reported at least one episode per week. Based on the results of PSQI and the characteristics of clinical OSA assessment, we can conclude that the patients with OSA present an impaired quality of socio-professional life.
C1 [Neagos, Adriana] George Emil Palade Univ Med Pharm Sci & Technol, Dept Otorhinolaryngol, Targu Mures, Romania.
   [Costache, Adrian] Univ Med & Pharm Carol Davila, Dept Pathol, Bucharest, Romania.
   [Gheorghe, Dan] Univ Med & Pharm Carol Davila, ENT Dept, Bucharest, Romania.
   [Georgescu, Madalina] Univ Med & Pharm Carol Davila, Dept Audiol, Bucharest, Romania.
   [Necula, Violeta] Univ Med & Pharm Iuliu Hatieganu, Dept Otorhinolaryngol, Cluj Napoca, Romania.
   [Martu, Cristian; Olariu, Raluca] Univ Med & Pharm Grigore T Popa, Otorhinolaryngol, Dept Surg 2, Iasi, Romania.
   [Paduraru, Luminita] Univ Med & Pharm Grigore T Popa, Dept Mother & Child Care, Iasi, Romania.
   [Budacu, Cristian] Univ Med & Pharm Grigore T Popa, Dept Surg Dentoalveolar & Maxillofacial Surg, Iasi, Romania.
   [Vrinceanu, Daniela] Univ Med & Pharm Carol Davila, Dept Otorhinolaryngol, Bucharest, Romania.
   [Hinganu, Delia] Univ Med & Pharm Grigore T Popa, Morphofunct Sci Dept 1, Iasi, Romania.
   [Cozma, Sebastian] Grigore T Popa Univ Med & Pharm, Fac Med, Otorhinolaryngol, Dept Surg 2, Iasi, Romania.
C3 George Emil Palade University of Medicine, Pharmacy, Science, &
   Technology of Targu Mures; Carol Davila University of Medicine &
   Pharmacy; Carol Davila University of Medicine & Pharmacy; Carol Davila
   University of Medicine & Pharmacy; Iuliu Hatieganu University of
   Medicine & Pharmacy; Grigore T Popa University of Medicine & Pharmacy;
   Grigore T Popa University of Medicine & Pharmacy; Grigore T Popa
   University of Medicine & Pharmacy; Carol Davila University of Medicine &
   Pharmacy; Grigore T Popa University of Medicine & Pharmacy; Grigore T
   Popa University of Medicine & Pharmacy
RP Necula, V (corresponding author), Univ Med & Pharm Iuliu Hatieganu, Dept Otorhinolaryngol, Cluj Napoca, Romania.; Olariu, R (corresponding author), Univ Med & Pharm Grigore T Popa, Otorhinolaryngol, Dept Surg 2, Iasi, Romania.
EM neagos.adriana@gmail.com; adriancostacheeco@yahoo.com;
   gheorghe.dancristian@gmail.com; madalina.georgescu@gecad.com;
   neculav@yahoo.com; cristianmartu@gmail.com; luminita.paduraru@gmail.com;
   cristibudacu@yahoo.com; raluca_bcn@yahoo.com; vrinceanudana@yahoo.com;
   delia_f24@yahoo.com; scozma2005@yahoo.com
RI PADURARU, LUMINITA/V-5559-2018; Budacu, Cristian/V-7185-2017; Georgescu,
   Madalina/AAJ-9008-2021; Vrinceanu, Daniela/AAL-5792-2021; Gheorghe, Dan
   Cristian/HLG-7729-2023; Hinganu, Delia/K-5918-2013; Olariu,
   Raluca/JZD-3422-2024; Cozma, Sebastian/IAP-0885-2023; Costache,
   Adrian/AAZ-6762-2020; COZMA, Romica Sebastian/L-7558-2013; Necula,
   Violeta/AAJ-5768-2020
OI OLARIU, Raluca/0009-0001-1221-5397; COZMA, Romica
   Sebastian/0000-0002-3768-6232; Martu, Cristian/0000-0001-8011-7361;
   Gheorghe, Dan Cristian/0000-0002-4883-3920; Necula,
   Violeta/0000-0001-8415-555X; Paduraru, Luminita/0000-0002-3850-797X
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NR 29
TC 1
Z9 1
U1 2
U2 13
PU EXPERT PROJECTS PUBLISHING
PI IASI
PA IASI, STR VOINESTI 63, IASI, 700615, ROMANIA
SN 1583-3410
EI 1584-5397
J9 REV CERCET INTERV SO
JI Rev. Cercet. Interv. Soc.
PD MAR
PY 2021
VL 72
BP 338
EP 352
DI 10.33788/rcis.72.21
PG 15
WC Social Sciences, Interdisciplinary
WE Social Science Citation Index (SSCI)
SC Social Sciences - Other Topics
GA QY7MQ
UT WOS:000630221900021
OA gold
DA 2025-06-11
ER

PT J
AU Alghamdi, AS
   Alwadeai, KS
   Almeshari, MA
   Alhammad, SA
   Alsaif, SS
   Alshehri, WA
   Alahmari, MA
   Alanazi, TM
   Siraj, RA
   Abuguyan, F
   Alotaibi, TF
   Algarni, SS
AF Alghamdi, Abdulrhman S.
   Alwadeai, Khalid S.
   Almeshari, Mohammed A.
   Alhammad, Saad A.
   Alsaif, Sulaiman S.
   Alshehri, Wael A.
   Alahmari, Mushabbab A.
   Alanazi, Turki M.
   Siraj, Rayan A.
   Abuguyan, Fahad
   Alotaibi, Tareq F.
   Algarni, Saleh S.
TI Prevalence of Obesity and Its Associated Comorbidities in Adults with
   Asthma: A Single-Center Study in Saudi Arabia
SO MEDICINA-LITHUANIA
LA English
DT Article
DE body mass index; diabetes mellitus; cardiovascular disease; allergic
   rhinitis; sinusitis; gastroesophageal reflux disease; obstructive sleep
   apnea
ID METABOLIC SYNDROME; INFLAMMATION; ANXIETY
AB Background and Objectives: Asthma is associated with several comorbidities, one of which is obesity. The worldwide increase in obesity has been accompanied by a parallel rise in asthma prevalence, with obesity recognized as a significant risk factor for both the development and severity of asthma. Obesity is often linked to various comorbidities, which can complicate asthma management and lead to poorer clinical outcomes. This study aims to investigate the prevalence of obesity and its comorbidities in adults with asthma in a single center in Saudi Arabia, providing an overview of the associated health implications. Materials and Methods: This single-center, retrospective study aimed to assess the prevalence of obesity and other comorbidities in asthma patients. Data were collected from King Khalid University Hospital in Saudi Arabia between July 2023 and December 2023. Results: This study revealed that 72.1% of asthma patients were either obese or overweight. Female patients had significantly higher BMI values compared to males. Our study revealed that 38.21% of female asthma patients (mean age = 57 +/- 13.85 years) had comorbidities compared to 24.14% of male asthma patients (mean age = 59 +/- 14.02 years). Furthermore, the proportion of obese asthmatic patients with comorbidities was significantly greater than those without comorbidities. Conclusions: This study investigates obesity prevalence and associated comorbidities in adult asthmatics in a single center in Saudi Arabia. The findings reveal a 72.1% rate of obesity and overweight among asthmatic patients, with higher BMI and comorbidity prevalence in females. These results underscore the need for targeted interventions addressing obesity and comorbidities, especially in female asthmatics.
C1 [Alghamdi, Abdulrhman S.; Alwadeai, Khalid S.; Almeshari, Mohammed A.; Alhammad, Saad A.; Alsaif, Sulaiman S.] King Saud Univ, Coll Appl Med Sci, Dept Hlth Rehabil Sci, Riyadh 11411, Saudi Arabia.
   [Alshehri, Wael A.] King Saud Univ Med City Hosp, Dept Resp Therapy, Riyadh 12372, Saudi Arabia.
   [Alahmari, Mushabbab A.] Univ Bisha, Coll Appl Med Sci, Dept Resp Therapy, Bisha 67714, Saudi Arabia.
   [Alahmari, Mushabbab A.] Univ Bisha, Hlth & Humanities Res Ctr, Bisha 67714, Saudi Arabia.
   [Alanazi, Turki M.] King Saud bin Abdelaziz Univ Hlth Sci, Dept Resp Therapy, Al Hasa 31982, Saudi Arabia.
   [Alanazi, Turki M.] King Abdullah Int Med Res Ctr, Al Hasa 31982, Saudi Arabia.
   [Siraj, Rayan A.] King Faisal Univ, Coll Appl Med Sci, Dept Resp Care, Al Hasa 31982, Saudi Arabia.
   [Abuguyan, Fahad] King Saud Univ, Coll Med, Dept Emergency Med, Riyadh 11411, Saudi Arabia.
   [Alotaibi, Tareq F.; Algarni, Saleh S.] King Saud bin Abdulaziz Univ Hlth Sci, Coll Appl Med Sci, Dept Resp Therapy, Riyadh 14611, Saudi Arabia.
   [Alotaibi, Tareq F.; Algarni, Saleh S.] King Abdullah Int Med Res Ctr, Riyadh 11481, Saudi Arabia.
   [Algarni, Saleh S.] King Abdul Aziz Med City, Resp Serv, Riyadh 11426, Saudi Arabia.
C3 King Saud University; University of Bisha; University of Bisha; King
   Saud Bin Abdulaziz University for Health Sciences; King Faisal
   University; King Saud University; King Saud Bin Abdulaziz University for
   Health Sciences
RP Alghamdi, AS (corresponding author), King Saud Univ, Coll Appl Med Sci, Dept Hlth Rehabil Sci, Riyadh 11411, Saudi Arabia.
EM aalghamdi5@ksu.edu.sa; shammad@ksu.edu.sa; salsaif3@ksu.edu.sa;
   walshehri3@ksu.edu.sa
RI Abuguyan, Fahad/KHZ-2010-2024; Alwadeai, Khalid/KYO-9640-2024; Siraj,
   Rayan/HHS-7286-2022; Alsaif, Sulaiman S./HHZ-0089-2022; Alghamdi,
   Abdulrhman/HPC-0045-2023; Alwadeai, Khalid/AFP-3007-2022; Almeshari,
   Mohammed A/ABF-2385-2020; Alahmari, Mushabbab/LJM-4326-2024
OI Alwadeai, Khalid/0000-0002-7816-3120; Alghamdi,
   Abdulrhman/0000-0001-6413-5746; Almeshari, Mohammed
   A/0000-0001-8449-9491; Abuguyan, Fahad/0000-0003-1243-5709; Alshehri,
   Wael/0009-0005-0255-8942; Alahmari, Mushabbab/0000-0003-3381-509X;
   Siraj, Rayan A/0000-0002-4238-9419
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NR 55
TC 1
Z9 1
U1 4
U2 4
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1010-660X
EI 1648-9144
J9 MEDICINA-LITHUANIA
JI Med. Lith.
PD NOV
PY 2024
VL 60
IS 11
AR 1785
DI 10.3390/medicina60111785
PG 12
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA N6R5C
UT WOS:001365587200001
PM 39596970
OA gold
DA 2025-06-11
ER

PT J
AU Lambert, EA
   Teede, H
   Sari, CI
   Jona, E
   Shorakae, S
   Woodington, K
   Hemmes, R
   Eikelis, N
   Straznicky, NE
   De Courten, B
   Dixon, JB
   Schlaich, MP
   Lambert, GW
AF Lambert, Elisabeth A.
   Teede, Helena
   Sari, Carolina Ika
   Jona, Eveline
   Shorakae, Soulmaz
   Woodington, Kiri
   Hemmes, Robyn
   Eikelis, Nina
   Straznicky, Nora E.
   De Courten, Barbora
   Dixon, John B.
   Schlaich, Markus P.
   Lambert, Gavin W.
TI Sympathetic activation and endothelial dysfunction in polycystic ovary
   syndrome are not explained by either obesity or insulin resistance
SO CLINICAL ENDOCRINOLOGY
LA English
DT Article
ID SUBCLINICAL ORGAN DAMAGE; NERVE ACTIVITY; METABOLIC SYNDROME; WOMEN;
   ANXIETY; RISK; ASSOCIATION; OVERWEIGHT; MARKERS
AB Objective Polycystic ovary syndrome (PCOS) is a common endocrine condition underpinned by insulin resistance and associated with increased risk of obesity, type 2 diabetes and adverse cardiovascular risk profile. Previous data suggest autonomic imbalance [elevated sympathetic nervous system (SNS) activity and decreased heart rate variability (HRV)] as well as endothelial dysfunction in PCOS. However, it is not clear whether these abnormalities are driven by obesity and metabolic disturbance or whether they are independently related to PCOS.
   Participants and methods We examined multiunit and single-unit muscle SNS activity (by microneurography), HRV (time and frequency domain analysis) and endothelial function [ischaemic reactive hyperaemia index (RHI) using the EndoPAT device] in 19 overweight/obese women with PCOS (BMI: 31 +/- 1.5 kg/m(2), age: 31 +/- 1.6 years) and compared them with 21 control overweight/obese women (BMI: 33 +/- 1.4 kg/m(2), age: 28 +/- 1.6 years) presenting a similar metabolic profile (fasting total, HDL and LDL cholesterol, glucose, triglycerides, insulin sensitivity and blood pressure).
   Results Women with PCOS had elevated multiunit muscle SNS activity (41 +/- 2 vs 33 +/- 3 bursts per 100 heartbeats, P < 0.05). Single-unit analysis showed that vasoconstrictor neurons were characterized by elevated firing rate and probability and incidence of multiple spikes (P < 0.01 for all parameters). Women with PCOS also had impaired endothelial function (RHI: 1.77 +/- 0.14 vs 2.18 +/- 0.14, P < 0.05). HRV did not differ between the groups.
   Conclusion Women with PCOS have increased sympathetic drive and impaired endothelial function independent of obesity and metabolic disturbances. Sympathetic activation and endothelial dysfunction may confer greater cardiovascular risk in women with PCOS.
C1 [Lambert, Elisabeth A.; Sari, Carolina Ika; Woodington, Kiri; Hemmes, Robyn; Eikelis, Nina; Straznicky, Nora E.; Lambert, Gavin W.] Baker IDI Heart & Diabet Inst, Human Neurotransmitters Lab, Melbourne, Vic 8008, Australia.
   [Lambert, Elisabeth A.] Monash Univ, Dept Physiol, Clayton, Vic 3800, Australia.
   [Teede, Helena; Jona, Eveline; Shorakae, Soulmaz; De Courten, Barbora] Monash Univ & Monash Hlth, Monash Ctr Hlth Res & Implementat, Clayton, Vic, Australia.
   [Dixon, John B.] Baker IDI Heart & Diabet Inst, Clin Obes Res Lab, Melbourne, Vic 8008, Australia.
   [Schlaich, Markus P.] Baker IDI Heart & Diabet Inst, Hypertens & Kidney Dis Labs, Melbourne, Vic 8008, Australia.
   [Schlaich, Markus P.] Alfred Hosp, Primary Hlth Care, Prahran, Vic 3181, Australia.
   [Schlaich, Markus P.] Alfred Hosp, Dept Cardiovasc Med, Prahran, Vic 3181, Australia.
   [Lambert, Gavin W.] Monash Univ, Nursing & Hlth Sci, Fac Med, Clayton, Vic, Australia.
C3 Baker Heart and Diabetes Institute; Monash University; Baker Heart and
   Diabetes Institute; Baker Heart and Diabetes Institute; Florey Institute
   of Neuroscience & Mental Health; Howard Florey Institute Affiliates;
   Florey Institute of Neuroscience & Mental Health; Howard Florey
   Institute Affiliates; Monash University
RP Lambert, EA (corresponding author), Baker IDI Heart & Diabet Inst, POB 6492,St Kilda Rd Cent, Melbourne, Vic 8008, Australia.
EM elisabeth.lambert@bakeridi.edu.au
RI Schlaich, Markus/E-7468-2010; Lambert, Gavin/E-7384-2010; Lambert,
   Elisabeth/E-7463-2010; Dixon, John/A-5318-2011; Straznicky,
   Nora/E-7484-2010; de Courten, Barbora/B-3308-2012
OI de Courten, Barbora/0000-0001-8760-2511; Lambert,
   Elisabeth/0000-0002-2232-9048; Schlaich, Markus/0000-0002-1765-0195;
   Teede, Helena/0000-0001-7609-577X; Dixon, John/0000-0001-6399-7010;
   Lambert, Gavin/0000-0003-0315-645X
FU NHMRC [1022793]
FX NHMRC project grant 1022793.
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NR 36
TC 69
Z9 72
U1 1
U2 9
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0300-0664
EI 1365-2265
J9 CLIN ENDOCRINOL
JI Clin. Endocrinol.
PD DEC
PY 2015
VL 83
IS 6
BP 812
EP 819
DI 10.1111/cen.12803
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA DB1TX
UT WOS:000368293000010
PM 25926334
DA 2025-06-11
ER

PT J
AU Kharb, S
   Joshi, A
AF Kharb, Simmi
   Joshi, Anagha
TI Multi-omics and machine learning for the prevention and management of
   female reproductive health
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Review
DE pregnancy; endocrinology; metabolic syndrome; pregnancy complications;
   omics technologies; e-health; biomarkers
ID POLYCYSTIC-OVARY-SYNDROME; GENOME-WIDE ASSOCIATION; POSTPARTUM
   DEPRESSION; ANGIOGENIC BIOMARKERS; DEEP ENDOMETRIOSIS; PREECLAMPSIA;
   PREDICTION; RISK; PREGNANCY; DIAGNOSIS
AB Females typically carry most of the burden of reproduction in mammals. In humans, this burden is exacerbated further, as the evolutionary advantage of a large and complex human brain came at a great cost of women's reproductive health. Pregnancy thus became a highly demanding phase in a woman's life cycle both physically and emotionally and therefore needs monitoring to assure an optimal outcome. Moreover, an increasing societal trend towards reproductive complications partly due to the increasing maternal age and global obesity pandemic demands closer monitoring of female reproductive health. This review first provides an overview of female reproductive biology and further explores utilization of large-scale data analysis and -omics techniques (genomics, transcriptomics, proteomics, and metabolomics) towards diagnosis, prognosis, and management of female reproductive disorders. In addition, we explore machine learning approaches for predictive models towards prevention and management. Furthermore, mobile apps and wearable devices provide a promise of continuous monitoring of health. These complementary technologies can be combined towards monitoring female (fertility-related) health and detection of any early complications to provide intervention solutions. In summary, technological advances (e.g., omics and wearables) have shown a promise towards diagnosis, prognosis, and management of female reproductive disorders. Systematic integration of these technologies is needed urgently in female reproductive healthcare to be further implemented in the national healthcare systems for societal benefit.
C1 [Kharb, Simmi] Postgrad Inst Med Sci, Dept Biochem, Rohtak, Haryana, India.
   [Joshi, Anagha] Univ Bergen, Dept Clin Sci, Computat Biol Unit CBU, Bergen, Norway.
C3 University of Bergen
RP Kharb, S (corresponding author), Postgrad Inst Med Sci, Dept Biochem, Rohtak, Haryana, India.; Joshi, A (corresponding author), Univ Bergen, Dept Clin Sci, Computat Biol Unit CBU, Bergen, Norway.
EM simmikh@gmail.com; anagha.joshi@uib.no
RI Joshi, Anagha/MAI-1917-2025; , simmi/JSL-5008-2023
OI , simmi/0000-0002-1773-2422
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NR 121
TC 12
Z9 12
U1 5
U2 29
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD FEB 23
PY 2023
VL 14
AR 1081667
DI 10.3389/fendo.2023.1081667
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 9R4JU
UT WOS:000945622200001
PM 36909346
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Elizondo-Montemayor, L
   Hernández-Escobar, C
   Lara-Torre, E
   Nieblas, B
   Gómez-Carmona, M
AF Elizondo-Montemayor, Leticia
   Hernandez-Escobar, Claudia
   Lara-Torre, Eduardo
   Nieblas, Bianca
   Gomez-Carmona, Merith
TI Gynecologic and Obstetric Consequences of Obesity in Adolescent Girls
SO JOURNAL OF PEDIATRIC AND ADOLESCENT GYNECOLOGY
LA English
DT Review
DE Obesity; Adolescents; Girls; Gynecologic; Obstetric; Sexual maturation;
   Puberty; Pregnancy; Reproductive function; Polycystic ovary syndrome
ID POLYCYSTIC-OVARY-SYNDROME; BODY-MASS INDEX; BREAST-CANCER RISK;
   HORMONE-BINDING GLOBULIN; QUALITY-OF-LIFE; BONE MASS; PUBERTAL
   DEVELOPMENT; ENDOMETRIAL CANCER; DEPRESSIVE SYMPTOMS; METABOLIC SYNDROME
AB In the past few decades, there has been an overwhelming increase in childhood and adolescent obesity worldwide. Besides the well recognized cardiometabolic complications and other physical conditions associated with obesity, during adolescence, it causes psychological and social distress in a period of life that is already sensitive for a girl. This in turn increases their risk of low self-esteem and depression. Furthermore, obesity diminishes health-related quality of life and years of life. Overweight and obese teenagers are more likely to have gynecologic and obstetric complications, during adolescence and also later in life. Consequences of obese and overweight childhood and adolescence include sexual maturation and reproductive dysfunction, alterations in menstruation, dysmenorrhea, risky sexual behavior, and inefficient use of contraception, polycystic ovary syndrome, bone density abnormalities, macromastia, and an increased risk of breast and endometrial cancer. Obese adolescents are at greater risk of pregnancy and perinatal complications, such as preeclampsia, gestational hypertension and preeclampsia, gestational diabetes mellitus, primary cesarean delivery, and induction of labor, to mention a few. Evidence shows that infants born to obese teenagers are also more likely to have complications including preterm or post-term delivery, small-for-gestational age newborns, macrosomia, meconium aspiration, respiratory distress, and even stillbirth, among others. This comprehensive review focuses on the gynecological and obstetric consequences of obesity in adolescent girls.
C1 [Elizondo-Montemayor, Leticia; Hernandez-Escobar, Claudia; Nieblas, Bianca; Gomez-Carmona, Merith] Tecnol Monterrey, Escola Med, Ave Morones Prieto 3000 Pte Colonia Los Doctores, Monterrey 64710, Nuevo Leon, Mexico.
   [Lara-Torre, Eduardo] Virginia Tech, Carilion Sch Med, Carilion Clin, Roanoke, VA USA.
C3 Tecnologico de Monterrey; Virginia Polytechnic Institute & State
   University
RP Elizondo-Montemayor, L (corresponding author), Tecnol Monterrey, Escola Med, Ave Morones Prieto 3000 Pte Colonia Los Doctores, Monterrey 64710, Nuevo Leon, Mexico.
EM lelizond@itesm.mx
OI Nieblas, Bianca/0000-0002-8513-6163; Lara-Torre,
   Eduardo/0000-0001-6813-1822
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NR 201
TC 37
Z9 42
U1 0
U2 29
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1083-3188
EI 1873-4332
J9 J PEDIATR ADOL GYNEC
JI J. Pediatr Adolesc. Gynecol.
PD APR
PY 2017
VL 30
IS 2
BP 156
EP 168
DI 10.1016/j.jpag.2016.02.007
PG 13
WC Obstetrics & Gynecology; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Obstetrics & Gynecology; Pediatrics
GA EU6CZ
UT WOS:000401122900003
PM 26915924
DA 2025-06-11
ER

PT J
AU Pan, A
   Franco, OH
   Wang, YF
   Yu, ZJ
   Ye, XW
   Lin, X
AF Pan, An
   Franco, Oscar H.
   Wang, Yan-Fang
   Yu, Zhi-Jie
   Ye, Xing-Wang
   Lin, Xu
TI Prevalence and geographic disparity of depressive symptoms among
   middle-aged and elderly in China
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE depressive symptoms; chinese; CES-D; cross-sectional study
ID REPUBLIC-OF-CHINA; OLDER-PEOPLE; RISK-FACTORS; METABOLIC SYNDROME;
   MENTAL-DISORDERS; GLOBAL BURDEN; UNITED-STATES; LATER LIFE; MORTALITY;
   ADULTS
AB Background: To evaluate the prevalence of and risk factors for depressive symptoms among middle-aged and elderly Chinese in northern and southern China.
   Methods: A population-based cross-sectional survey was performed in Beijing and Shanghai. Participants included 3299 community residents aged 50-70. Socio-demographic, lifestyle and health-related information were obtained by a standardized questionnaire. Clinically relevant depressive symptoms were assessed by the Center for Epidemiological Studies of Depression Scale (CES-D).
   Results: The prevalence of depressive symptoms in the total study population was 9.5% (6.7% for men and 11.7% for women), and it was significantly higher in participants from Beijing than those from Shanghai (14.9% vs. 4.1%, P < 0.001). Multivariate logistic regression analyses indicated that this geographic disparity was independent of gender, age, marital status, living status, education level, health status, mobility, social activities and medical insurance (odds ratio, 3.94; 95% confidence interval, 2.86-5.40). Limitations: No clinical diagnostic validation was performed and the prevalence might be underestimated due to our exclusion criteria.
   Conclusions: Approximately one in ten middle-aged and elderly Chinese might suffer from depressive symptoms. Furthermore, the prevalence is substantially higher among residents in the north of China compared to the south. Prospective studies are required to confirm the results and identify the major risk factors contributing to this geographic disparity. (C) 2007 Elsevier B.V. All rights reserved.
C1 [Pan, An; Wang, Yan-Fang; Yu, Zhi-Jie; Ye, Xing-Wang; Lin, Xu] Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Shanghai, Peoples R China.
   [Pan, An; Wang, Yan-Fang; Yu, Zhi-Jie; Ye, Xing-Wang; Lin, Xu] Chinese Acad Sci, Grad Sch, Shanghai, Peoples R China.
   [Franco, Oscar H.] Unilever Corp Res, Sharnbrook MK44 1LQ, Beds, England.
C3 Chinese Academy of Sciences; Chinese Academy of Sciences; Unilever
RP Lin, X (corresponding author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Shanghai, Peoples R China.
EM xlin@sibs.ae.en
RI Franco, Óscar/ABE-2305-2020; Yu, Zhijie/AFT-1125-2022; lin,
   xu/KOC-3517-2024; Ye, Xingwang/D-5193-2011; Pan, An/C-5572-2011
OI Franco, Oscar/0000-0002-4606-4929; Pan, An/0000-0002-1089-7945
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NR 37
TC 56
Z9 60
U1 1
U2 28
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0165-0327
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD JAN
PY 2008
VL 105
IS 1-3
BP 167
EP 175
DI 10.1016/j.jad.2007.05.003
PG 9
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA 258YB
UT WOS:000252905200018
PM 17568685
DA 2025-06-11
ER

PT J
AU House, JS
   Mendez, M
   Maguire, RL
   Gonzalez-Nahm, S
   Huang, ZQ
   Daniels, J
   Murphy, SK
   Fuemmeler, BF
   Wright, FA
   Hoyo, C
AF House, John S.
   Mendez, Michelle
   Maguire, Rachel L.
   Gonzalez-Nahm, Sarah
   Huang, Zhiqing
   Daniels, Julie
   Murphy, Susan K.
   Fuemmeler, Bernard F.
   Wright, Fred A.
   Hoyo, Cathrine
TI Periconceptional Maternal Mediterranean Diet Is Associated With
   Favorable Offspring Behaviors and Altered CpG Methylation of Imprinted
   Genes
SO FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
LA English
DT Article
DE maternal diet; neuro-development; cord-blood methylation; child behavior
   disorders; ADHD-attention deficit disorder; autism spectrum disorder;
   epigenetics; imprinted genes
ID ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; CARDIOVASCULAR RISK-FACTORS;
   DNA METHYLATION; STYLE DIET; ACADEMIC-PERFORMANCE; METABOLIC SYNDROME;
   PRENATAL EXPOSURE; NONCODING RNA; LEAD-EXPOSURE; UNITED-STATES
AB Background: Maternal diet during pregnancy has been shown to influence the child neuro-developmental outcomes. Studies examining effects of dietary patterns on offspring behavior are sparse.
   Objective: Determine if maternal adherence to a Mediterranean diet is associated with child behavioral outcomes assessed early in life, and to evaluate the role of differentially methylated regions (DMRs) regulating genomically imprinted genes in these associations.
   Methods: Among 325 mother/infant pairs, we used regression models to evaluate the association between tertiles of maternal periconceptional Mediterranean diet adherence (MDA) scores derived from a Food Frequency Questionnaire, and social and emotional scores derived from the Infant Toddler Social and Emotional Assessment (ITSEA) questionnaire in the second year of life. Methylation of nine genomically imprinted genes was measured to determine if MDA was associated with CpG methylation.
   Results: Child depression was inversely associated with maternal MDA (Bonferroni-corrected p = 0.041). While controlling for false-discovery, compared to offspring of women with the lowest MDA tertile, those with MDA scores in middle and high MDA tertiles had decreased odds for atypical behaviors [OR (95% Cl) = 0.40 (0.20, 0.78) for middle and 0.40 (0.17, 0.92) for highest tertile], for maladaptive behaviors [0.37 (0.18, 0.72) for middle tertile and 0.42 (0.18, 0.95) for highest tertile] and for an index of autism spectrum disorder behaviors [0.46 (0.23, 0.90) for middle and 0.35 (0.15, 0.80) for highest tertile]. Offspring of women with the highest MDA tertile were less likely to exhibit depressive [OR = 0.28 (0.12, 0.64)] and anxiety [0.42 (0.18, 0.97)] behaviors and increased odds of social relatedness [2.31 (1.04, 5.19)] behaviors when compared to low MDA mothers. Some associations varied by sex. Perinatal MDA score was associated with methylation differences for imprinted control regions of PEG10/SGCE [females: Beta (95% Cl) = 1.66 (0.52, 2.80) - Bonferroni-corrected p = 0.048; males: -0.56 (-1.13, -0.00)], as well as both MEG3 and IGF2 in males [0.97 (0.00, 1.94)] and -0.92 (-1.65, -0.19) respectively.
   Conclusion: In this ethnically diverse cohort, maternal adherence to a Mediterranean diet in early pregnancy was associated with favorable neurobehavioral outcomes in early childhood and with sex-dependent methylation differences of MEG3, IGF2, and SGCE/PEG10 DMRs.
C1 [House, John S.; Wright, Fred A.] North Carolina State Univ, Bioinformat Res Ctr, Raleigh, NC 27695 USA.
   [House, John S.; Maguire, Rachel L.; Wright, Fred A.; Hoyo, Cathrine] North Carolina State Univ, Ctr Human Hlth & Environm, Raleigh, NC 27695 USA.
   [Mendez, Michelle] Univ Pittsburgh, Dept Environm & Occupat Hlth, Pittsburgh, PA USA.
   [Maguire, Rachel L.; Wright, Fred A.; Hoyo, Cathrine] North Carolina State Univ, Dept Biol Sci, Raleigh, NC USA.
   [Gonzalez-Nahm, Sarah] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Hlth Behav & Soc, Baltimore, MD USA.
   [Huang, Zhiqing; Murphy, Susan K.] Duke Univ, Med Ctr, Dept Obstet & Gynecol, Durham, NC 27710 USA.
   [Daniels, Julie] Univ N Carolina, Dept Epidemiol, Chapel Hill, NC 27515 USA.
   [Fuemmeler, Bernard F.] Virginia Commonwealth Univ, Dept Hlth Behav & Policy, Richmond, VA USA.
   [Wright, Fred A.] North Carolina State Univ, Dept Stat, Raleigh, NC USA.
C3 North Carolina State University; North Carolina State University;
   Pennsylvania Commonwealth System of Higher Education (PCSHE); University
   of Pittsburgh; North Carolina State University; Johns Hopkins
   University; Johns Hopkins Bloomberg School of Public Health; Duke
   University; University of North Carolina; University of North Carolina
   Chapel Hill; Virginia Commonwealth University; North Carolina State
   University
RP House, JS (corresponding author), North Carolina State Univ, Bioinformat Res Ctr, Raleigh, NC 27695 USA.; House, JS (corresponding author), North Carolina State Univ, Ctr Human Hlth & Environm, Raleigh, NC 27695 USA.
EM jshouse@ncsu.edu
RI Murphy, Susan/R-3903-2019; House, John/A-1933-2013; Daniels,
   Julie/ABD-1510-2021; Huang, Zhiqing/E-8836-2011; Stefanadis,
   Christodoulos/ABH-2232-2020
OI Hoyo, Cathrine/0000-0002-2466-8617; Murphy, Susan/0000-0001-8298-7272;
   Stefanadis, Christodoulos/0000-0001-5974-6454; House, John
   S./0000-0002-8447-7871; Fuemmeler, Bernard/0000-0002-3550-0107
FU National Institute of Environmental Health Sciences of the National
   Institutes of Health [P01ES022831, R21ES014947, R01ES016772,
   R01HD084487, P30ES025128]; U.S. Environmental Protection Agency
   [RD-83543701]; National Center for Advancing Translational Sciences
   [UL1TR001117]
FX The research was supported by National Institute of Environmental Health
   Sciences of the National Institutes of Health (P01ES022831, R21ES014947,
   R01ES016772, R01HD084487, and P30ES025128) and by the U.S. Environmental
   Protection Agency (RD-83543701). Additional support was provided by the
   National Center for Advancing Translational Sciences (UL1TR001117).
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NR 110
TC 48
Z9 51
U1 1
U2 8
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-634X
J9 FRONT CELL DEV BIOL
JI Front. Cell. Dev. Biol.
PD SEP 7
PY 2018
VL 6
AR 107
DI 10.3389/fcell.2018.00107
PG 13
WC Cell Biology; Developmental Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Developmental Biology
GA HG9OH
UT WOS:000455337700001
PM 30246009
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Chang, Y
   Noh, JW
   Cheon, JY
   Kim, Y
   Kwon, YD
   Ryu, S
AF Chang, Yoosoo
   Noh, Jin-Won
   Cheon, Joo Young
   Kim, Yejin
   Kwon, Young Dae
   Ryu, Seungho
TI Self-rated health and risk of incident non-alcoholic fatty liver
   disease: A cohort study
SO SCIENTIFIC REPORTS
LA English
DT Article
ID PHYSICAL-ACTIVITY; MORTALITY; OBESITY; QUESTIONNAIRE; RELIABILITY;
   ULTRASOUND; OVERWEIGHT; DIAGNOSIS; SYMPTOMS; ANXIETY
AB Although self-rated health (SRH), a subjective measure of overall health status, associates with metabolic abnormalities, studies on the relationship between SRH and non-alcoholic fatty liver disease (NAFLD), a hepatic manifestation of metabolic syndrome, are limited. In this study, we evaluated whether or not SRH predicts the risk of incident NAFLD. This cohort study was performed in a sample of 148,313 Korean adults free of ultrasound-diagnosed NAFLD at baseline with annual or biennial follow-up for a median of 3.7 years. SRH and NAFLD were measured at baseline and follow-up visits. NAFLD was determined based on the ultrasound-diagnosed fatty liver without excessive alcohol consumption or any other cause. Hazard ratios with 95% confidence intervals were estimated via a parametric proportional hazards model. During 522,696.1 person-years of follow-up, 23,855 individuals with new-onset NAFLD were identified (incidence rate, 45.6 per 1,000 person-years). After adjustments for possible confounders including total calorie intake, sleep duration, and depressive symptoms, the multivariate-adjusted hazard ratios (95% confidence intervals) for incident NAFLD comparing good, fair, and poor or very poor SRH to very good SRH were 1.06 (0.97-1.14), 1.18 (1.09-1.27), and 1.24 (1.13-1.37), respectively. This association of SRH with incident NAFLD remained significant after accounting for changes in SRH and confounders during follow-up and was similar across clinically relevant subgroups. In a large-scale cohort study of apparently healthy Korean adults, poor SRH was independently and positively associated with incident NAFLD risk, indicating a predictive role of SRH as a health measure in NAFLD.
C1 [Chang, Yoosoo; Ryu, Seungho] Sungkyunkwan Univ, Sch Med, Kangbuk Samsung Hosp, Dept Occupat & Environm Med, Seoul, South Korea.
   [Chang, Yoosoo; Kim, Yejin; Ryu, Seungho] Sungkyunkwan Univ, Kangbuk Samsung Hosp, Ctr Cohort Studies, Total Healthcare Ctr,Sch Med Seoul, Seoul, South Korea.
   [Chang, Yoosoo; Ryu, Seungho] Sungkyunkwan Univ, Dept Clin Res Design & Evaluat, SAIHST, Seoul, South Korea.
   [Noh, Jin-Won] Dankook Univ, Dept Hlth Adm, Coll Hlth Sci, Cheonan, South Korea.
   [Noh, Jin-Won] Dankook Univ, Inst Hlth Promot & Policy, Cheonan, South Korea.
   [Noh, Jin-Won] Univ Groningen, Univ Med Ctr Groningen, Dept Hlth Sci, Global Hlth Unit, Groningen, Netherlands.
   [Cheon, Joo Young] Sungshin Univ, Dept Nursing Sci, Seoul, South Korea.
   [Kwon, Young Dae] Catholic Univ Korea, Dept Humanities & Social Med, Coll Med, Seoul, South Korea.
   [Kwon, Young Dae] Catholic Univ Korea, Catholic Inst Healthcare Management, Seoul, South Korea.
C3 Sungkyunkwan University (SKKU); Samsung Medical Center; Sungkyunkwan
   University (SKKU); Samsung Medical Center; Sungkyunkwan University
   (SKKU); Dankook University; Dankook University; University of Groningen;
   Sungshin Women's University; Catholic University of Korea; Catholic
   University of Korea
RP Ryu, S (corresponding author), Sungkyunkwan Univ, Sch Med, Kangbuk Samsung Hosp, Dept Occupat & Environm Med, Seoul, South Korea.; Ryu, S (corresponding author), Sungkyunkwan Univ, Kangbuk Samsung Hosp, Ctr Cohort Studies, Total Healthcare Ctr,Sch Med Seoul, Seoul, South Korea.; Ryu, S (corresponding author), Sungkyunkwan Univ, Dept Clin Res Design & Evaluat, SAIHST, Seoul, South Korea.
EM sh703.yoo@gmail.com
RI Kwon, Young Dae/AGO-9431-2022; Kwon, Young Dae/T-1591-2017
OI Kwon, Young Dae/0000-0002-8781-6832; Chang, Yoosoo/0000-0002-6945-9050;
   Ryu, Seungho/0000-0002-3927-8646; Noh, Jin-Won/0000-0001-5172-4023
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NR 52
TC 0
Z9 0
U1 0
U2 2
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD MAR 2
PY 2020
VL 10
IS 1
AR 3826
DI 10.1038/s41598-020-60823-8
PG 8
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Science & Technology - Other Topics
GA NE8WP
UT WOS:000562886200051
PM 32123241
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Brand, S
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   Ludyga, S
   Emmenegger, R
   Kalak, N
   Bahmani, DS
   Holsboer-Trachsler, E
   Pühse, U
   Gerber, M
AF Brand, Serge
   Colledge, Flora
   Ludyga, Sebastian
   Emmenegger, Raphael
   Kalak, Nadeem
   Bahmani, Dena Sadeghi
   Holsboer-Trachsler, Edith
   Puhse, Uwe
   Gerber, Markus
TI Acute Bouts of Exercising Improved Mood, Rumination and Social
   Interaction in Inpatients With Mental Disorders
SO FRONTIERS IN PSYCHOLOGY
LA English
DT Article
DE physical activity; mental disorders; mood; rumination; trans-diagnostic
ID REPETITIVE NEGATIVE THINKING; MAJOR DEPRESSIVE DISORDER;
   PHYSICAL-ACTIVITY; AEROBIC EXERCISE; METABOLIC SYNDROME; BIPOLAR
   DISORDER; SEDENTARY BEHAVIOR; ANXIETY DISORDERS; PEOPLE; METAANALYSIS
AB Background: Studies at the macro level (such as longer-term interventions) showed that physical activity impacts positively on cognitive-emotional processes of patients with mental disorders. However, research focusing on the immediate impact of acute bouts of exercise (micro level) are missing. The aim of the present study was therefore to investigate whether and to what extent single bouts of moderately intense exercise can influence dimensions of psychological functioning in inpatients with mental disorders.
   Method: 129 inpatients (mean age: 38.16 years; 50.4% females) took part and completed a questionnaire both immediately before and immediately after exercising. Thirty inpatients completed the questionnaires a second time in the same week. The questionnaire covered socio-demographic and illness-related information. Further, the questionnaire asked about current psychological states such as mood, rumination, social interactions, and attention, tiredness, and physical strengths as a proxy of physiological states.
   Results: Psychological states improved from pre- to post-session. Improvements were observed for mood, social interactions, attention, and physical strengths. Likewise, rumination and tiredness decreased. Mood, rumination, and tiredness further improved, when patients completed the questionnaires the second time in the same week.
   Conclusion: At micro level, single bouts of exercise impacted positively on cognitive-motional processes such as mood, rumination, attention and social interactions, and physiological states of tiredness and physical strengths among inpatients with mental disorders. In addition, further improvements were observed, if patients participated in physical activities a second time.
C1 [Brand, Serge; Colledge, Flora; Ludyga, Sebastian; Emmenegger, Raphael; Puhse, Uwe; Gerber, Markus] Univ Basel, Dept Sport Exercise & Hlth, Div Sport Sci & Psychosocial Hlth, Basel, Switzerland.
   [Brand, Serge; Kalak, Nadeem; Bahmani, Dena Sadeghi; Holsboer-Trachsler, Edith] Univ Basel, Ctr Affect Stress & Sleep Disorders, Psychiat Clin, Basel, Switzerland.
   [Brand, Serge; Bahmani, Dena Sadeghi] Kermanshah Univ, Subst Abuse Prevent Res Ctr, Med Sci, Kermanshah, Iran.
   [Brand, Serge; Bahmani, Dena Sadeghi] Kermanshah Univ, Sleep Disorders Res Ctr, Med Sci, Kermanshah, Iran.
C3 Swiss School of Public Health (SSPH+); University of Basel; University
   of Basel; Kermanshah University of Medical Sciences; Kermanshah
   University of Medical Sciences
RP Brand, S (corresponding author), Univ Basel, Dept Sport Exercise & Hlth, Div Sport Sci & Psychosocial Hlth, Basel, Switzerland.; Brand, S (corresponding author), Univ Basel, Ctr Affect Stress & Sleep Disorders, Psychiat Clin, Basel, Switzerland.; Brand, S (corresponding author), Kermanshah Univ, Subst Abuse Prevent Res Ctr, Med Sci, Kermanshah, Iran.; Brand, S (corresponding author), Kermanshah Univ, Sleep Disorders Res Ctr, Med Sci, Kermanshah, Iran.
EM serge.brand@upkbs.ch
RI Bahmani, Dena/H-8271-2019; Gerber, Markus/H-8654-2014; Brand,
   Serge/H-7159-2019; Ludyga, Sebastian/H-9316-2019
OI Ludyga, Sebastian/0000-0002-3905-7894; Gerber,
   Markus/0000-0001-6140-8948; Brand, Serge/0000-0003-2175-2765
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NR 88
TC 54
Z9 57
U1 0
U2 47
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-1078
J9 FRONT PSYCHOL
JI Front. Psychol.
PD MAR 13
PY 2018
VL 9
AR 249
DI 10.3389/fpsyg.2018.00249
PG 11
WC Psychology, Multidisciplinary
WE Social Science Citation Index (SSCI)
SC Psychology
GA FZ0XJ
UT WOS:000427298100001
PM 29593592
OA Green Accepted, Green Published, gold
DA 2025-06-11
ER

PT J
AU De Lorenzo, A
   Pellegrini, M
   Gualtieri, P
   Itani, L
   El Ghoch, M
   Di Renzo, L
AF De Lorenzo, Antonino
   Pellegrini, Massimo
   Gualtieri, Paola
   Itani, Leila
   El Ghoch, Marwan
   Di Renzo, Laura
TI The Risk of Sarcopenia among Adults with Normal-Weight Obesity in a
   Nutritional Management Setting
SO NUTRIENTS
LA English
DT Article
DE body composition; BMI; body fat; DXA; normal body weight; obesity;
   sarcopenia; sarcopenic obesity
ID BODY-COMPOSITION; DIAGNOSTIC-CRITERIA; METABOLIC SYNDROME; ASSOCIATION;
   PREVALENCE; INFLAMMATION; DEPRESSION; HEALTH; IMPACT; WOMEN
AB Normal-weight obesity (NWO) is a phenotype characterized by excessive body fat (BF) despite normal body weight. We aimed to assess the association between NWO and the risk of sarcopenia. Two groups of patients with a normal body mass index [BMI (20-24.9 kg/m(2))] were selected from a large cohort of participants. Body composition was measured using dual-energy X-ray absorptiometry (DXA), and 748 participants were categorized as NWO or normal-weight without obesity (NWNO) and were classed according to whether or not they were at risk of sarcopenia. The "NWO group" included 374 participants (cases), compared to 374 participants (controls) in the "NWNO group", all of a similar BMI, age and gender. The participants in the "NWO group" displayed a higher prevalence of the risk of sarcopenia than the control group across both genders (0.6% vs. 14.1% in males; 1.4% vs. 36.5% in females). Regression analysis showed that being in the NWO category increased the risk of sarcopenia 22-fold in males (RR = 22.27; 95%CI: 3.35-147.98) and 25-fold in females (RR = 25.22; 95%CI: 8.12-78.36), compared to those in the NWNO category. In a "real-world" nutritional setting, the assessment of body composition to identify NWO syndrome is vital since it is also associated with a higher risk of sarcopenia.
C1 [De Lorenzo, Antonino; Gualtieri, Paola; Di Renzo, Laura] Univ Tor Vergata, Dept Biomed & Prevent, Sect Clin Nutr & Nutrigenom, Via Montpellier 1, I-00133 Rome, Italy.
   [Pellegrini, Massimo] Univ Modena & Reggio Emilia, Dept Biomed Metab & Neural Sci, I-41125 Modena, Italy.
   [Itani, Leila; El Ghoch, Marwan] Beirut Arab Univ, Fac Hlth Sci, Dept Nutr & Dietet, Beirut 11072, Lebanon.
C3 University of Rome Tor Vergata; Universita di Modena e Reggio Emilia;
   Beirut Arab University
RP El Ghoch, M (corresponding author), Beirut Arab Univ, Fac Hlth Sci, Dept Nutr & Dietet, Beirut 11072, Lebanon.
EM m.ghoch@bau.edu.lb
RI Itani, Leila/S-6451-2017; Di Renzo, Laura/ACB-2003-2022; El Ghoch,
   Marwan/T-8329-2019; Gualtieri, Paola/AAS-1684-2020; PELLEGRINI,
   Massimo/P-6359-2016
OI Gualtieri, Paola/0000-0003-1533-4276; El Ghoch,
   Marwan/0000-0003-4277-4752; De Lorenzo, Antonino/0000-0001-6524-4493;
   PELLEGRINI, Massimo/0000-0002-0091-0077; di renzo,
   laura/0000-0001-8875-6723
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NR 41
TC 10
Z9 10
U1 0
U2 7
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD DEC
PY 2022
VL 14
IS 24
AR 5295
DI 10.3390/nu14245295
PG 7
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 7H1HQ
UT WOS:000902961200001
PM 36558454
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Schouten, J
   Su, T
   Wit, FW
   Kootstra, NA
   Caan, MWA
   Geurtsen, GJ
   Schmand, BA
   Stolte, IG
   Prins, M
   Majoie, CB
   Portegies, P
   Reiss, P
AF Schouten, Judith
   Su, Tanja
   Wit, Ferdinand W.
   Kootstra, Neeltje A.
   Caan, Matthan W. A.
   Geurtsen, Gert J.
   Schmand, Ben A.
   Stolte, Ineke G.
   Prins, Maria
   Majoie, Charles B.
   Portegies, Peter
   Reiss, Peter
CA AGEhIV Study Grp
TI Determinants of reduced cognitive performance in HIV-1-infected
   middle-aged men on combination antiretroviral therapy
SO AIDS
LA English
DT Article
DE HIV infection; risk factors; cognitive impairment; determinants;
   HIV-associated neurocognitive disorders
ID VASCULAR RISK-FACTORS; CORONARY-HEART-DISEASE; NEUROCOGNITIVE
   IMPAIRMENT; INSULIN-RESISTANCE; METABOLIC SYNDROME; IMMUNE ACTIVATION;
   HIV; PREVALENCE; INDIVIDUALS; DEPRESSION
AB Objective:
   The spectrum of risk factors for HIV-associated cognitive impairment is likely very broad and includes not only HIV/antiretroviral therapy-specific factors but also other comorbid conditions. The purpose of this current study was to explore possible determinants for decreased cognitive performance.
   Design and methods:
   Neuropsychological assessment was performed on 103 HIV-1-infected men with suppressed viraemia on combination antiretroviral therapy for at least 12 months and 74 HIV-uninfected highly similar male controls, all aged at least 45 years. Cognitive impairment and cognitive performance were determined by multivariate normative comparison (MNC). Determinants of decreased cognitive performance and cognitive impairment were investigated by linear and logistic regression analysis, respectively.
   Results:
   Cognitive impairment as diagnosed by MNC was found in 17% of HIV-1-infected men. Determinants for decreased cognitive performance by MNC as a continuous variable included cannabis use, history of prior cardiovascular disease, impaired renal function, diabetes mellitus type 2, having an above normal waist-to-hip ratio, presence of depressive symptoms, and lower nadir CD4(+) cell count. Determinants for cognitive impairment, as dichotomized by MNC, included cannabis use, prior cardiovascular disease, impaired renal function, and diabetes mellitus type 2.
   Conclusion:
   Decreased cognitive performance probably results from a multifactorial process, including not only HIV-associated factors, such as having experienced more severe immune deficiency, but also cardiovascular/metabolic factors, cannabis use, and depressive symptoms.
C1 [Schouten, Judith; Wit, Ferdinand W.; Reiss, Peter] Univ Amsterdam, Acad Med Ctr, Dept Global Hlth, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands.
   [Schouten, Judith; Wit, Ferdinand W.; Reiss, Peter] Amsterdam Inst Global Hlth & Dev, Amsterdam, Netherlands.
   [Schouten, Judith; Portegies, Peter] Univ Amsterdam, Dept Neurol, Amsterdam, Netherlands.
   [Su, Tanja; Caan, Matthan W. A.; Majoie, Charles B.] Univ Amsterdam, Dept Radiol, Amsterdam, Netherlands.
   [Wit, Ferdinand W.; Stolte, Ineke G.; Prins, Maria; Reiss, Peter] Univ Amsterdam, Ctr Infect & Immun Amsterdam CINIMA, Dept Internal Med, Div Infect Dis, Amsterdam, Netherlands.
   [Kootstra, Neeltje A.] Univ Amsterdam, Dept Expt Immunol, Amsterdam, Netherlands.
   [Geurtsen, Gert J.; Schmand, Ben A.] Univ Amsterdam, Acad Med Ctr, Dept Med Psychol, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands.
   [Schmand, Ben A.] Univ Amsterdam, Dept Psychol, Amsterdam, Netherlands.
   [Stolte, Ineke G.; Prins, Maria] Onze Lieve Vrouw Hosp, Publ Hlth Serv Amsterdam, Infect Dis Res, Amsterdam, Netherlands.
   [Portegies, Peter] Onze Lieve Vrouw Hosp, Dept Neurol, Amsterdam, Netherlands.
   [Reiss, Peter] Onze Lieve Vrouw Hosp, Dutch HIV Monitoring Fdn, Amsterdam, Netherlands.
C3 University of Amsterdam; Academic Medical Center Amsterdam; University
   of Amsterdam; University of Amsterdam; University of Amsterdam;
   University of Amsterdam; University of Amsterdam; University of
   Amsterdam; Public Health Service Amsterdam; Onze Lieve Vrouwe Gasthuis
   Hospital; Onze Lieve Vrouwe Gasthuis Hospital; Onze Lieve Vrouwe
   Gasthuis Hospital
RP Schouten, J (corresponding author), Acad Med Ctr, Amsterdam Inst Global Hlth & Dev, Dept Global Hlth, Trinity Bldg C,3rd Floor,Pietersbergweg 17, NL-1105 BM Amsterdam, Zuidoost, Netherlands.; Schouten, J (corresponding author), Acad Med Ctr, Amsterdam Inst Global Hlth & Dev, Dept Neurol, Trinity Bldg C,3rd Floor,Pietersbergweg 17, NL-1105 BM Amsterdam, Zuidoost, Netherlands.
EM j.schouten@amc.nl
RI Kootstra, Neeltje/JAD-1996-2023; Geurtsen, G.J./HHM-8358-2022
OI Geurtsen, G.J./0000-0002-2508-340X; Su, Tanja/0000-0001-7982-0391;
   Kootstra, Neeltje A./0000-0001-9429-7754; Caan, Matthan
   W.A./0000-0002-5162-8880
FU Nuts-OHRA Foundation, Amsterdam, The Netherlands [1003-026]; Netherlands
   Organisation for Health Research and Development (ZonMW); AIDS Fonds
   [300020007, 2009063]
FX This work was supported by the Nuts-OHRA Foundation (grant no.
   1003-026), Amsterdam, The Netherlands, as well as by The Netherlands
   Organisation for Health Research and Development (ZonMW) together with
   AIDS Fonds (grant nos 300020007 and 2009063, respectively).
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NR 56
TC 90
Z9 98
U1 0
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0269-9370
EI 1473-5571
J9 AIDS
JI Aids
PD APR 24
PY 2016
VL 30
IS 7
BP 1027
EP 1038
DI 10.1097/QAD.0000000000001017
PG 12
WC Immunology; Infectious Diseases; Virology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Infectious Diseases; Virology
GA DI1AT
UT WOS:000373229100001
PM 26752277
DA 2025-06-11
ER

PT J
AU Sodhi, RK
   Kumar, H
   Singh, R
   Bansal, Y
   Kondepudi, KK
   Bishnoi, M
   Kuhad, A
AF Sodhi, Rupinder Kaur
   Kumar, Hemant
   Singh, Raghunath
   Bansal, Yashika
   Kondepudi, Kanthi Kiran
   Bishnoi, Mahendra
   Kuhad, Anurag
TI Protective effects of menthol against olanzapine-induced metabolic
   alterations in female mice
SO EUROPEAN JOURNAL OF PHARMACOLOGY
LA English
DT Article
DE TRPM8 channels; menthol; Olanzapine; Metabolic syndrome; Antipsychotics;
   AMTB
ID HEPATIC STEATOSIS; PROTEIN-KINASE; EXPRESSION; TRPM8; BETA
AB Aim: Metabolic comorbidities such as obesity type 2 diabetes, insulin resistance, glucose intolerance, dyslipidemia are the major contributors for lower life expectancy and reduced patient compliance during antipsychotic therapy in patients with severe mental illnesses such as schizophrenia, bipolar disorder, and depression. TRPM8 activation by menthol is also reported to alleviate high fat diet-induced obesity in mice. Additionally, this TRPM8 activation leads to increase in gene expression of thermogenic genes in white adipocytes and dietary menthol was found to increase browning of WAT along with improved glucose utilization. Therefore, we aimed to evaluate the plausible role of TRPM8 channels in olanzapine-induced metabolic alterations in female balb/c mice. Methods: 6 weeks olanzapine (6 mg kg(-1), per oral) model was used in female balb/c mice. Pharmacological manipulation of TRPM8 channel was done using menthol and N-(3-aminopropyl)-2-[(3-methylphenyl)methoxy]-N-(2-thienylmethyl)-benzamide (AMTB), the agonist and antagonist respectively. Key results: Menthol co-treatment for six weeks prevented olanzapine-induced metabolic alterations such as weight gain, increased food intake, decreased energy expenditure, adiposity, liver lipid accumulation, systemic inflammation and insulin resistance. Although no significant change in TRPM8 mRNA expression was found in the hypothalamus, however, some of the protective effects of menthol were absent in presence of AMTB indicating possible involvement of TRPM8 channels. Conclusion: Our results suggest possible therapeutic implications of menthol in the management of antipsychotic-induced weight gain and other metabolic alterations.
C1 [Sodhi, Rupinder Kaur; Kumar, Hemant; Kuhad, Anurag] Panjab Univ, Univ Inst Pharmaceut Sci, Pharmacol Res Lab, Sect 14, Chandigarh, India.
   [Singh, Raghunath] Ctr Addict & Mental Hlth CAMH, Schizophrenia Div, Toronto, ON, Canada.
   [Bansal, Yashika] Ctr Addict & Mental Hlth CAMH, Campbell Family Mental Hlth Res Inst, Toronto, ON, Canada.
   [Kondepudi, Kanthi Kiran; Bishnoi, Mahendra] Natl Agrifood Biotechnol Inst NABI, Ctr Excellence Funct Foods, TRiP Hlth Lab, Knowledge City Sect 81, Sahibzada Ajit Singh Naga 140603, Punjab, India.
C3 Panjab University; University of Toronto; Centre for Addiction & Mental
   Health - Canada; University of Toronto; Centre for Addiction & Mental
   Health - Canada; Department of Biotechnology (DBT) India; National Agri
   Food Biotechnology Institute (NABI)
RP Kuhad, A (corresponding author), Panjab Univ, Univ Inst Pharmaceut Sci, Pharmacol Res Lab, Sect 14, Chandigarh, India.; Bishnoi, M (corresponding author), Natl Agrifood Biotechnol Inst NABI, Ctr Excellence Funct Foods, TRiP Hlth Lab, Knowledge City Sect 81, Sahibzada Ajit Singh Naga 140603, Punjab, India.
EM mbishnoi@gmail.com; anurag.kuhad@pu.ac.in
RI Bishnoi, Mahendra/CAG-3229-2022; Kondepudi, Kanthi/P-8336-2014; SINGH,
   RAGHUNATH/F-7993-2012
OI Singh, Raghunath/0000-0001-9411-7426
FU SERB-DST (Science and Engineering Research Board- Department of Science
   and Technology, Govt of India) [EMR/2017/003589]; Department of
   Biotechnology (DBT), Government of India
FX Research grant awarded to Dr Anurag Kuhad and Senior Research Fellowship
   awarded to Rupinder Kaur Sodhi by SERB-DST (Science and Engineering
   Research Board- Department of Science and Technology, Govt of India)
   (Grant no- EMR/2017/003589) is gratefully acknowledged. Authors would
   also like to thank Department of Biotechnology (DBT), Government of
   India for research grant given to National Agri-Food Biotechnology
   Institute (NABI), Dr. Mahendra Bishnoi.
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NR 45
TC 0
Z9 0
U1 1
U2 3
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0014-2999
EI 1879-0712
J9 EUR J PHARMACOL
JI Eur. J. Pharmacol.
PD NOV 15
PY 2024
VL 983
AR 177010
DI 10.1016/j.ejphar.2024.177010
EA SEP 2024
PG 10
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA H6R7D
UT WOS:001324698900001
PM 39299481
DA 2025-06-11
ER

PT J
AU Shao, TN
   Yin, GZ
   Yin, XL
   Wu, JQ
   Du, XD
   Zhu, HL
   Liu, JH
   Wang, XQ
   Xu, DW
   Tang, WJ
   Hui, L
AF Shao, Tian Nan
   Yin, Guang Zhong
   Yin, Xiao Li
   Wu, Jing Qin
   Du, Xiang Dong
   Zhu, Hong Liang
   Liu, Jia Hong
   Wang, Xiao Qiong
   Xu, Dong Wu
   Tang, Wen Jie
   Hui, Li
TI Elevated triglyceride levels are associated with cognitive impairments
   among patients with major depressive disorder
SO COMPREHENSIVE PSYCHIATRY
LA English
DT Article
ID SERUM-LIPID CONCENTRATIONS; QUALITY-OF-LIFE; METABOLIC SYNDROME;
   UNIPOLAR DEPRESSION; RISK-FACTORS; HIPPOCAMPAL VOLUME;
   INSULIN-RESISTANCE; BIPOLAR DISORDER; VERBAL MEMORY; METAANALYSIS
AB Background: Cognitive deficits have been identified as one of core clinical symptoms of major depressive disorder (MDD). Accumulating evidence indicated that triglycerides (TG) might be associated with MDD and cognitive decline.
   Objective: This study examined whether patients with MDD had poorer cognitive functions than healthy controls, and further investigate whether TG levels were involved in MDD, and its cognitive impairments in a Han Chinese population.
   Method: 115 patients with MDD and 119 healthy controls were enrolled. Cognitive functions were assessed by the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), and serum TG levels were examined using enzymatic colorimetry.
   Results: TG levels were higher in patients with MDD than healthy controls after controlling for the variables. Cognitive test scores were lower in patients with MDD than healthy controls except for visuospatial/constructional index after controlling for the variables. TG levels were negatively correlated with visuospatial/constructional score, delayed memory score and RBANS total score of MDD. Further multivariate regression analysis showed that TG levels were negatively associated with visuospatial/constructional score, attention score, delayed memory score and RBANS total score of MDD.
   Conclusions: Our findings supported that serum TG levels might be involved in MDD, and play an important role in cognitive impairments of MDD, especially in delayed memory. Moreover, patients with MDD experienced greater cognitive impairments than healthy controls except for visuospatial/constructional index. (C) 2017 Elsevier Inc. All rights reserved.
C1 [Shao, Tian Nan; Tang, Wen Jie; Hui, Li] Wenzhou Med Univ, Sch Clin Med 1, Wenzhou, Zhejiang, Peoples R China.
   [Shao, Tian Nan; Tang, Wen Jie; Hui, Li] Suzhou Psychiat Hosp, Suzhou, Jiangsu, Peoples R China.
   [Shao, Tian Nan; Yin, Guang Zhong; Wu, Jing Qin; Du, Xiang Dong; Zhu, Hong Liang; Hui, Li] Soochow Univ, Affiliated Guangji Hosp, Inst Mental Hlth, Suzhou Psychiat Hosp, 286 Guangji Rd, Suzhou 218005, Jiangsu, Peoples R China.
   [Shao, Tian Nan; Yin, Xiao Li; Liu, Jia Hong; Wang, Xiao Qiong; Hui, Li] Wenzhou Med Univ, Kangning Hosp, Wenzhou Kangning Hosp, Wenzhou, Zhejiang, Peoples R China.
   [Xu, Dong Wu] Wenzhou Med Univ, Sch Mental Hlth, Wenzhou, Zhejiang, Peoples R China.
C3 Wenzhou Medical University; Soochow University - China; Wenzhou Medical
   University; Wenzhou Medical University
RP Tang, WJ (corresponding author), Wenzhou Med Univ, Sch Clin Med 1, Wenzhou, Zhejiang, Peoples R China.; Hui, L (corresponding author), Soochow Univ, Affiliated Guangji Hosp, Inst Mental Hlth, Suzhou Psychiat Hosp, 286 Guangji Rd, Suzhou 218005, Jiangsu, Peoples R China.
EM 13606777777@qq.com; huili004100@126.com
RI Yin, Guang-Zhong/ABB-5957-2020; Yin, xiaoli/MVY-0739-2025; Wu,
   Jingqin/V-9319-2019; wang, xiao/HGB-7081-2022
OI Wu, Jingqin/0000-0002-2052-3875
FU National Natural Science Foundation of China [81501160]; Young Medical
   Talent of Jiangsu Province [QNRC2016228]; Wenzhou Municipal Sci-Tech
   Bureau Program [Y20160073]; Suzhou Key Diagnosis and Treatment Program
   [LCZX201615]; Jiangsu Province Natural Science Fund Project
   [BK20151197]; Suzhou Key Medical Center for Psychiatric Diseases
   [Szzx201509]; Zhejiang Province Rising Star in Medicine
FX This study was funded by the grants from National Natural Science
   Foundation of China (81501160), the Young Medical Talent of Jiangsu
   Province (QNRC2016228), the Wenzhou Municipal Sci-Tech Bureau Program
   (Y20160073), the Suzhou Key Diagnosis and Treatment Program
   (LCZX201615), the Jiangsu Province Natural Science Fund Project
   (BK20151197), Suzhou Key Medical Center for Psychiatric Diseases
   (Szzx201509), and Zhejiang Province Rising Star in Medicine. These
   sources had no further role in this study design, data collection and
   analysis, writing of the report, and decision to submit the paper for
   publication.
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NR 65
TC 32
Z9 34
U1 0
U2 10
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0010-440X
EI 1532-8384
J9 COMPR PSYCHIAT
JI Compr. Psychiat.
PD MAY
PY 2017
VL 75
BP 103
EP 109
DI 10.1016/j.comppsych.2017.03.007
PG 7
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA ET4BW
UT WOS:000400225000014
PM 28342378
DA 2025-06-11
ER

PT J
AU Schmitz, K
   Mangels, N
   Häussler, A
   Ferreiros, N
   Fleming, I
   Tegeder, I
AF Schmitz, K.
   Mangels, N.
   Haeussler, A.
   Ferreiros, N.
   Fleming, I.
   Tegeder, I.
TI Pro-inflammatory obesity in aged cannabinoid-2 receptor-deficient mice
SO INTERNATIONAL JOURNAL OF OBESITY
LA English
DT Article
ID ADIPOSE-TISSUE MACROPHAGES; CB2 RECEPTOR; FOOD-INTAKE; ENDOCANNABINOID
   SYSTEM; DIABETIC-NEUROPATHY; INSULIN-RESISTANCE; ENERGY-BALANCE;
   IMMUNE-SYSTEM; T-CELLS; ACTIVATION
AB BACKGROUND AND OBJECTIVES: Cannabinoid-1 receptor signaling increases the rewarding effects of food intake and promotes the growth of adipocytes, whereas cannabinoid-2 receptor (CB2) possibly opposes these pro-obesity effects by silencing the activated immune cells that are key drivers of the metabolic syndrome. Pro-and anti-orexigenic cannabimimetic signaling may become unbalanced with age because of alterations of the immune and endocannabinoid system.
   METHODS: To specifically address the role of CB2 for age-associated obesity, we analyzed metabolic, cardiovascular, immune and neuronal functions in 1.2-1.8-year-old CB2(-/-) and control mice, fed with a standard diet and assessed effects of the CB2 agonist, HU308, during high-fat diet (HFD) in 12-16-week-old mice.
   RESULTS: The CB2(-/-) mice were obese with hypertrophy of visceral fat, immune cell polarization toward pro-inflammatory subpopulations in fat and liver and hypertension, as well as increased mortality despite normal blood glucose. They also developed stronger paw inflammation and a premature loss of transient receptor potential responsiveness in primary sensory neurons, a phenomenon typical for small fiber disease. The CB2 agonist HU308 prevented HFD-evoked hypertension, reduced HFD-evoked polarization of adipose tissue macrophages toward the M1-like pro-inflammatory type and reduced HFD-evoked nociceptive hypersensitivity, but had no effect on weight gain.
   CONCLUSIONS: CB2 agonists may fortify CB2-mediated anti-obesity signaling without the risk of anti-CB1-mediated depression that caused the failure of rimonabant.
C1 [Schmitz, K.; Haeussler, A.; Ferreiros, N.; Tegeder, I.] Goethe Univ Hosp, Inst Clin Pharmacol, Frankfurt, Germany.
   [Mangels, N.; Fleming, I.] Goethe Univ Hosp, Inst Vasc Signaling, Frankfurt, Germany.
   [Tegeder, I.] Fraunhofer Inst Mol Biol & Appl Ecol, Project Grp Translat Med & Pharmacol IME TMP, Frankfurt, Germany.
C3 Goethe University Frankfurt; Goethe University Frankfurt Hospital;
   Goethe University Frankfurt; Goethe University Frankfurt Hospital;
   Fraunhofer Gesellschaft; Fraunhofer Germany; Fraunhofer Molecular
   Biology & Applied Ecology
RP Tegeder, I (corresponding author), Goethe Univ Hosp, Inst Clin Pharmacol ZAFES, Theodor Stern Kai 7, D-60590 Frankfurt, Germany.
EM tegeder@em.uni-frankfurt.de
RI Tegeder, Irmgard/AAM-2266-2020; Fleming, Ingrid/L-1225-2014
OI Fleming, Ingrid/0000-0003-1881-3635
FU Deutsche Forschungsgemeinschaft [CRC1039]; Else Kroner Fresenius
   Foundation (Translational Research Innovation Pharma (TRIP) graduate
   school)
FX We acknowledge the financial support of the Deutsche
   Forschungsgemeinschaft (CRC1039 A03 to IT, and Z1) and the Else Kroner
   Fresenius Foundation (Translational Research Innovation Pharma (TRIP)
   graduate school, scholar KS). We thank Sandra Labocha and Yannick
   Schreiber for technical assistance.
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NR 64
TC 39
Z9 41
U1 0
U2 12
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0307-0565
EI 1476-5497
J9 INT J OBESITY
JI Int. J. Obes.
PD FEB
PY 2016
VL 40
IS 2
SI SI
BP 366
EP 379
DI 10.1038/ijo.2015.169
PG 14
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA DD1OR
UT WOS:000369691500025
PM 26303348
OA Bronze
DA 2025-06-11
ER

PT J
AU Chiu, MH
   Heydari, B
   Batulan, Z
   Maarouf, N
   Subramanya, V
   Schenck-Gustafsson, K
   O'Brien, ER
AF Chiu, Michael H.
   Heydari, Bobak
   Batulan, Zarah
   Maarouf, Nadia
   Subramanya, Vinita
   Schenck-Gustafsson, Karin
   O'Brien, Edward R.
TI Coronary artery disease in post-menopausal women: are there appropriate
   means of assessment?
SO CLINICAL SCIENCE
LA English
DT Review
ID FRACTIONAL FLOW RESERVE; ISCHEMIC-HEART-DISEASE; ELEVATION
   MYOCARDIAL-INFARCTION; SEX-RELATED DIFFERENCES; EMISSION
   COMPUTED-TOMOGRAPHY; ADENOSINE STRESS PERFUSION; SUPPRESS ADVERSE
   OUTCOMES; RAPID RISK STRATIFICATION; ESTROGEN PLUS PROGESTIN; CARDIAC
   SYNDROME-X
AB The recognition of sex differences in cardiovascular disease, particularly the manifestations of coronary artery disease (CAD) in post-menopausal women, has introduced new challenges in not only understanding disease mechanisms but also identifying appropriate clinical means of assessing the efficacy of management strategies. For example, the majority of treatment algorithms for CAD are derived from the study of males, focus on epicardial stenoses, and inadequately account for the small intramyocardial vessel disease in women. However, newer investigational modalities, including stress perfusion cardiac magnetic resonance imaging and positron emission tomography are providing enhanced diagnostic accuracy and prognostication for women with microvascular disease. Moreover, these investigations may soon be complemented by simpler screening tools such as retinal vasculature imaging, as well as novel biomarkers (e.g. heat shock protein 27). Hence, it is vital that robust, sex-specific cardiovascular imaging modalities and biomarkers continue to be developed and are incorporated into practice guidelines that are used to manage women with CAD, as well as gauge the efficacy of any new treatment modalities. This review provides an overview of some of the sex differences in CAD and highlights emerging advances in the investigation of CAD in post-menopausal women.
C1 [Chiu, Michael H.; Heydari, Bobak; Batulan, Zarah; Maarouf, Nadia; O'Brien, Edward R.] Univ Calgary, Cumming Sch Med, Dept Cardiac Sci, Libin Cardiovasc Inst Alberta, Calgary, AB, Canada.
   [Subramanya, Vinita] Johns Hopkins Sch Med, Div Cardiol, Dept Med, Baltimore, MD 21205 USA.
   [Schenck-Gustafsson, Karin] Karolinska Inst, Dept Med, Cardiac Unit, Stockholm, Sweden.
   [Schenck-Gustafsson, Karin] Karolinska Inst, Ctr Gender Med, Stockholm, Sweden.
C3 Libin Cardiovascular Institute Of Alberta; University of Calgary; Johns
   Hopkins University; Johns Hopkins Medicine; Karolinska Institutet;
   Karolinska Institutet
RP O'Brien, ER (corresponding author), Univ Calgary, Cumming Sch Med, Dept Cardiac Sci, Libin Cardiovasc Inst Alberta, Calgary, AB, Canada.
EM ermobrie@ucalgary.ca
RI Heydari, Bobak/HTL-6853-2023; O'Brien, Edward/J-6621-2013
OI Schenck-Gustafsson, Karin/0000-0002-3659-5101
FU Canadian Institute for Health Research (CIHR) [PJT-149015]; CIHR
   Strategy for Patient-Oriented Research-Patient-Oriented Research
   Collaboration Grant [PEG-151774]
FX This manuscript was supported by research grants to E.R. O'Brien from
   the Canadian Institute for Health Research (CIHR) sponsored Canadian
   Vascular Network, a CIHR Project Grant [PJT-149015]; and a CIHR Strategy
   for Patient-Oriented Research-Patient-Oriented Research Collaboration
   Grant [PEG-151774].
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NR 135
TC 22
Z9 24
U1 0
U2 6
PU PORTLAND PRESS LTD
PI LONDON
PA 1ST FLR, 10 QUEEN STREET PLACE, LONDON, ENGLAND
SN 0143-5221
EI 1470-8736
J9 CLIN SCI
JI Clin. Sci.
PD SEP 14
PY 2018
VL 132
IS 17
BP 1937
EP 1952
DI 10.1042/CS20180067
PG 16
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Research & Experimental Medicine
GA GS5RW
UT WOS:000443729100005
PM 30185615
DA 2025-06-11
ER

PT J
AU O'Brien, MJ
   Perez, A
   Alos, VA
   Whitaker, RC
   Ciolino, JD
   Mohr, DC
   Ackermann, RT
AF O'Brien, Matthew J.
   Perez, Alberly
   Alos, Victor A.
   Whitaker, Robert C.
   Ciolino, Jody D.
   Mohr, David C.
   Ackermann, Ronald T.
TI The Feasibility, Acceptability, and Preliminary Effectiveness of a
   Promotora-Led Diabetes Prevention Program (PL-DPP) in Latinas: A Pilot
   Study
SO DIABETES EDUCATOR
LA English
DT Article
ID LIFE-STYLE INTERVENTION; COMMUNITY-BASED TRANSLATION; SF-36 HEALTH
   SURVEY; QUALITY-OF-LIFE; WEIGHT-LOSS; PSYCHOMETRIC PROPERTIES;
   MULTIDIMENSIONAL SCALE; CONCEPTUAL-FRAMEWORK; METABOLIC SYNDROME;
   DEPRESSION
AB Purpose The purpose of this pilot study is to test the feasibility, acceptability, and preliminary effectiveness of a Promotora-Led Diabetes Prevention Program (PL-DPP) in Hispanic women (Latinas).
   Methods Twenty Latina adults with prediabetes were enrolled in this single-arm pilot trial of PL-DPP. Participants underwent a year-long lifestyle intervention consisting of 24 sessions divided into 14 weekly core sessions and 10 post-core sessions offered either biweekly or monthly. Each session was led by a promotora in Spanish. The primary outcome was weight change over the 12-month study period.
   Results The study participants were socioeconomically challenged, middle-aged Latinas with limited access to health care. Eighteen participants (90%) completed at least 12 sessions, and 1 was lost to follow-up. Overall, participants reported high levels of satisfaction with PL-DPP. At 12 months, the participants achieved a mean weight loss of 10.8 pounds, which corresponded to 5.6% of initial body weight. Significant pre-post reductions in waist circumference, diastolic blood pressure, LDL cholesterol, and insulin levels were also observed. Modest reductions in A1C and fasting plasma glucose were not significant.
   Conclusions The PL-DPP demonstrated feasibility, acceptability, and preliminary effectiveness in a high-risk population of Latinas. Future research examining this intervention in a randomized clinical trial should explore factors impacting its effects using both qualitative and quantitative methods.
C1 [O'Brien, Matthew J.; Ackermann, Ronald T.] Northwestern Univ, Feinberg Sch Med, Div Gen Internal Med & Geriatr, Chicago, IL 60611 USA.
   [O'Brien, Matthew J.; Ackermann, Ronald T.] Northwestern Univ, Feinberg Sch Med, Ctr Community Hlth, Inst Publ Hlth & Med, Chicago, IL 60611 USA.
   [O'Brien, Matthew J.; Perez, Alberly; Alos, Victor A.; Whitaker, Robert C.] Temple Univ, Ctr Obes Res & Educ, Philadelphia, PA 19122 USA.
   [O'Brien, Matthew J.; Perez, Alberly; Alos, Victor A.; Whitaker, Robert C.] Temple Univ, Dept Publ Hlth, Philadelphia, PA 19122 USA.
   [O'Brien, Matthew J.; Perez, Alberly; Alos, Victor A.] Puentes Salud Hlth & Wellness Ctr, Philadelphia, PA USA.
   [Ciolino, Jody D.; Mohr, David C.] Northwestern Univ, Feinberg Sch Med, Dept Prevent Med, Chicago, IL 60611 USA.
C3 Northwestern University; Feinberg School of Medicine; Northwestern
   University; Feinberg School of Medicine; Pennsylvania Commonwealth
   System of Higher Education (PCSHE); Temple University; Pennsylvania
   Commonwealth System of Higher Education (PCSHE); Temple University;
   Northwestern University; Feinberg School of Medicine
RP O'Brien, MJ (corresponding author), Northwestern Univ, Feinberg Sch Med, 750 North Lake Shore Dr,6th Floor, Chicago, IL 60611 USA.
EM matthew.obrien1@northwestern.edu
OI Mohr, David/0000-0002-5443-7596
FU National Institute of Diabetes and Digestive and Kidney Diseases,
   National Institutes of Health [K23-DK095981]
FX Financial support for this study was provided from the National
   Institute of Diabetes and Digestive and Kidney Diseases, National
   Institutes of Health (K23-DK095981, O'Brien PI).
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NR 58
TC 27
Z9 37
U1 2
U2 25
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0145-7217
EI 1554-6063
J9 DIABETES EDUCATOR
JI Diabetes Educ.
PD AUG
PY 2015
VL 41
IS 4
BP 485
EP 494
DI 10.1177/0145721715586576
PG 10
WC Endocrinology & Metabolism; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Public, Environmental & Occupational Health
GA CM9IV
UT WOS:000358023000009
PM 26023095
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Ramsey, CM
   Leoutsakos, JM
   Mayer, LS
   Eaton, WW
   Lee, HB
AF Ramsey, Christine M.
   Leoutsakos, Jeannie-Marie
   Mayer, Lawrence S.
   Eaton, William W.
   Lee, Hochang B.
TI History of manic and hypomanic episodes and risk of incident
   cardiovascular disease: 11.5 year follow-up from the Baltimore
   Epidemiologic Catchment Area Study
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Mania; Hypomania; Cardiovascular disease; Bipolar disorder; ECA
ID DIAGNOSTIC INTERVIEW SCHEDULE; CORONARY-HEART-DISEASE; BIPOLAR-DISORDER;
   MYOCARDIAL-INFARCTION; MEDICAL COMORBIDITY; SUBSTANCE USE;
   PSYCHIATRIC-DISORDERS; METABOLIC SYNDROME; MAJOR DEPRESSION;
   MENTAL-DISORDERS
AB Background: While several studies have suggested that bipolar disorder may elevate risk of cardiovascular disease, few studies have examined the relationship between mania or hypomania and cardiovascular disease. The purpose of this study is to examine history of manic and hypomanic episodes as an independent risk factor for cardiovascular disease (CVD) during an 11.5 year follow-up of the Baltimore Epidemiologic Catchment Area Follow-up Study.
   Methods: All participants were psychiatrically assessed face-to-face based on Diagnostic Interview Schedule in 1981 and 1982 and were categorized as having either history of manic or hypomanic episode (MHE; n = 58), major depressive episode only (MDE; n = 71) or no mood episode (NME; n= 1339). Incident cardiovascular disease (CVD; n=67) was determined by self-report of either myocardial infarction (MI) or congestive heart failure (CHF) in 1993-6.
   Results: Compared with NME subjects, the odds ratio for incident CVD among MHE subjects was 2.97 (95% confidence interval: 1.40, 6.34) after adjusting for putative risk factors.
   Conclusions: These data suggest that a history of MHE increase the risk of incident CVD among community residents. Recognition of manic symptoms and addressing related CVD risk factors could have long term preventative implications in the development of cardiovascular disease in the community. (C) 2010 Published by Elsevier B.V.
C1 [Ramsey, Christine M.; Leoutsakos, Jeannie-Marie; Mayer, Lawrence S.; Lee, Hochang B.] Johns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, Baltimore, MD 21224 USA.
   [Mayer, Lawrence S.; Eaton, William W.; Lee, Hochang B.] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Mental Hlth, Baltimore, MD 21224 USA.
C3 Johns Hopkins University; Johns Hopkins University; Johns Hopkins
   Bloomberg School of Public Health
RP Ramsey, CM (corresponding author), Johns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, 5300 Alpha Commons Dr,AC4, Baltimore, MD 21224 USA.
EM Cramsey7@jhmi.edu
RI lee, hy/GRS-0797-2022
OI Lee, Hochang/0000-0001-8379-4018; Leoutsakos,
   Jeannie-Marie/0000-0002-1010-1046
FU National Institute of Mental Health [MH68793, MH47447]; NIDA [DA 026652]
FX This research was supported by grants MH68793 (Lee) and MH47447 (Eaton)
   from the National Institute of Mental Health. The authors would like to
   acknowledge support from NIDA grant DA 026652.
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   [No title captured]
NR 56
TC 37
Z9 40
U1 0
U2 5
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD SEP
PY 2010
VL 125
IS 1-3
BP 35
EP 41
DI 10.1016/j.jad.2009.12.024
PG 7
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA 644KW
UT WOS:000281377100005
PM 20570367
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Kridin, K
   Schonmann, Y
   Bitan, DT
   Damiani, G
   Weinstein, O
   Cohen, AD
AF Kridin, Khalaf
   Schonmann, Yochai
   Bitan, Dana Tzur
   Damiani, Giovanni
   Weinstein, Orly
   Cohen, Arnon D.
TI The Burden of Coronavirus Disease 2019 and Its Complications in Patients
   With Atopic Dermatitis-A Nested Case-Control Study
SO DERMATITIS
LA English
DT Article
ID RHEUMATIC-DISEASES; INCREASED RISK; COVID-19; OUTCOMES; ASSOCIATION;
   INFECTIONS; DIAGNOSIS; COHORT
AB Background: The burden of coronavirus disease 2019 (COVID-19) among patients with atopic dermatitis (AD) is poorly understood.
   Objectives: The aims of the study were to characterize a large cohort of COVID-19-positive adult patients with AD and to identify predictors of COVID-19-associated hospitalization and mortality.
   Methods: A population-based nested case-control study was performed. Multivariable logistic regression was used to evaluate odds ratios and 95% confidence intervals of predictors for COVID-19-associated hospitalization and mortality.
   Results: Of 78,073 adult patients with AD, 3618 (4.6%) tested positive for COVID-19. Subclinical COVID-19 infection occurred in 3368 (93.1%) of COVID-19-positive patients, whereas 123 (3.4%), 46 (1.3%), 55 (1.5%), and 26 (0.7%) patients developed a mild, moderate, severe, and critical disease, respectively. Altogether, 250 patients (6.0%) were hospitalized, and 40 patients (1.1%) died because of COVID-19 complications. Coronavirus disease 2019-associated hospitalization was independently associated with the intake of extended courses of systemic corticosteroids (adjusted odds ratio, 1.96; 95% confidence interval, 1.23-3.14; P = 0.005). None of AD-related variables independently predicted COVID-19-associated mortality. The presence of comorbid metabolic syndrome, chronic obstructive pulmonary disease, chronic renal failure, and depression projected both COVID-19-associated hospitalization and mortality.
   Conclusions: Prolonged systemic corticosteroids during the pandemic are associated with increased odds of COVID-19-associated hospitalization and should be avoided in patients with AD.
C1 [Kridin, Khalaf] Univ Lubeck, Lubeck Inst Expt Dermatol, Ratzeburger Allee 160, D-23562 Lubeck, Germany.
   [Kridin, Khalaf] Bar Ilan Univ, Azrieli Fac Med, Safed, Israel.
   [Schonmann, Yochai; Weinstein, Orly; Cohen, Arnon D.] Clalit Hlth Serv, Tel Aviv, Israel.
   [Schonmann, Yochai; Cohen, Arnon D.] Ben Gurion Univ Negev, Sial Res Ctr, Div Community Hlth, Beer Sheva, Israel.
   [Bitan, Dana Tzur] Ariel Univ, Dept Behav Sci, Ariel, Israel.
   [Bitan, Dana Tzur] Shalvata Mental Hlth Ctr, Hod Hasharon, Israel.
   [Bitan, Dana Tzur] Tel Aviv Univ, Sackler Sch Med, Ramat Aviv, Israel.
   [Damiani, Giovanni] IRCCS Ist Ortoped Galeazzi, Clin Dermatol, Milan, Italy.
   [Weinstein, Orly] Ben Gurion Univ Negev, Fac Hlth Sci, Beer Sheva, Israel.
C3 University of Lubeck; Bar Ilan University; Clalit Health Services;
   Ben-Gurion University of the Negev; Ariel University; Tel Aviv
   University; Tel Aviv University; Sackler Faculty of Medicine; IRCCS
   Istituto Ortopedico Galeazzi; Ben-Gurion University of the Negev
RP Kridin, K (corresponding author), Univ Lubeck, Lubeck Inst Expt Dermatol, Ratzeburger Allee 160, D-23562 Lubeck, Germany.
EM dr_kridin@hotmail.com
RI Tzur Bitan, Dana/ADF-2704-2022; Damiani, Giovanni/AAG-6507-2019; Kridin,
   Khalaf/ABD-8694-2020; Schonmann, Yochai/O-8983-2019
OI Schonmann, Yochai/0000-0002-4483-2277; Damiani,
   Giovanni/0000-0002-2390-6505
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NR 41
TC 4
Z9 4
U1 0
U2 3
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1710-3568
EI 2162-5220
J9 DERMATITIS
JI Dermatitis
PD OCT
PY 2021
VL 32
IS 1S
SU 1
BP S45
EP S52
DI 10.1097/DER.0000000000000772
PG 8
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA WK7OD
UT WOS:000709911900010
PM 34138775
DA 2025-06-11
ER

PT J
AU Lerchbaum, E
AF Lerchbaum, Elisabeth
TI Vitamin D and menopause-A narrative review
SO MATURITAS
LA English
DT Review
DE Vitamin D; Menopause; Cardiovascular disease; Musculoskeletal disease;
   Obesity
ID IMPAIRED GLUCOSE-TOLERANCE; LIPID-ACCUMULATION PRODUCT; D
   SUPPLEMENTATION; DOUBLE-BLIND; METABOLIC DISTURBANCES;
   CARDIOVASCULAR-DISEASE; CALCIUM-ABSORPTION; VASOMOTOR SYMPTOMS;
   HYPOVITAMINOSIS D; BONE TURNOVER
AB There is accumulating evidence that vitamin D (VD) has important effects besides its well-known role in calcium and bone metabolism. Hypovitaminosis D is associated with cardiovascular disease, the metabolic syndrome, type 2 diabetes mellitus, cancer as well as with increased mortality. Further, VD deficiency is related to depression and impaired cognitive function. Increasing age and elevated body fat mass contribute to an increased risk of VD deficiency. Further, some studies report a relationship between VD and estrogen metabolism.
   During menopause, the decline of estrogens results in increased bone turnover, a decrease in bone mineral density and elevated fracture risk. Musculoskeletal discomfort might impair quality of life, mood disturbances do frequently occur and the risk of metabolic and cardiovascular disease increases. Moreover, body composition changes including increased fat mass and decreased lean mass, which results in an increased risk of VD deficiency. Conversely, VD deficiency might aggravate discomfort as well as diseases that occur during menopause.
   There are precise recommendations regarding a sufficient VD intake in order to prevent bone loss in peri- and postmenopausal women. Considering the fact that VD deficiency and menopause share risk factors beyond bone health such as cardiovascular, metabolic, cognitive and affective disorders, a sufficient VD status should be obtained in all pen- and postmenopausal women. This might be beneficial not only considering bone health but also regarding cognitive, affective, metabolic and cardiovascular health of women. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
C1 Med Univ Graz, Dept Internal Med, Div Endocrinol & Metab, A-8036 Graz, Austria.
C3 Medical University of Graz
RP Lerchbaum, E (corresponding author), Med Univ Graz, Dept Internal Med, Div Endocrinol & Metab, Auenbruggerpl 15, A-8036 Graz, Austria.
EM elisabeth.lerchbaum@medunigraz.at
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NR 54
TC 48
Z9 49
U1 2
U2 19
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0378-5122
EI 1873-4111
J9 MATURITAS
JI Maturitas
PD SEP
PY 2014
VL 79
IS 1
BP 3
EP 7
DI 10.1016/j.maturitas.2014.06.003
PG 5
WC Geriatrics & Gerontology; Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology; Obstetrics & Gynecology
GA AP2KH
UT WOS:000341900600002
PM 24993517
DA 2025-06-11
ER

PT J
AU Amini, Z
   Boyd, B
   Doucet, J
   Ribnicky, DM
   Stephens, JM
AF Amini, Zhaleh
   Boyd, Bryant
   Doucet, Julie
   Ribnicky, David M.
   Stephens, Jacqueline M.
TI St. John's Wort inhibits adipocyte differentiation and induces insulin
   resistance in adipocytes
SO BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
LA English
DT Article
DE Adipogenesis; Adipocyte; Botanicals; St. John's Wort; 3T3-L1
ID PREGNANE-X-RECEPTOR; ADIPOSE-TISSUE; OBESITY
AB Adipocytes are insulin sensitive cells that play a major role in energy homeostasis. Obesity is the primary disease of fat cells and a major risk factor for the development of Type II diabetes, cardiovascular disease, and metabolic syndrome. Obesity and its related disorders result in dysregulation of the mechanisms that control adipocyte gene expression and function. To identify potential novel therapeutic modulators of adipocytes, we screened 425 botanical extracts for their ability to modulate adipogenesis and insulin sensitivity. We observed that less than 2% of the extracts had substantial effects on adipocyte differentiation of 3T3-L1 cells. Two of the botanical extracts that inhibited adipogenesis were extracts from St. John's Wort (SJW). Our studies revealed that leaf and flower, but not root, extracts isolated from SJW inhibited adipogenesis as judged by examining PPAR gamma and adiponectin levels. We also examined the effects of these SJW extracts on insulin sensitivity in mature 3T3-L1 adipocytes. Both leaf and flower extracts isolated from SJW substantially inhibited insulin sensitive glucose uptake. The specificity of the observed effects was demonstrated by showing that treatment with SJW flower extract resulted in a time and dose dependent inhibition of insulin stimulated glucose uptake. SJW is commonly used in the treatment of depression. However, our studies have revealed that SJW may have a negative impact on adipocyte related diseases by limiting differentiation of preadipocytes and significantly inducing insulin resistance in mature fat cells. (C) 2009 Elsevier Inc. All rights reserved.
C1 [Amini, Zhaleh; Boyd, Bryant; Doucet, Julie; Stephens, Jacqueline M.] Louisiana State Univ, Dept Biol Sci, Baton Rouge, LA 70803 USA.
   [Ribnicky, David M.] Rutgers State Univ, New Brunswick, NJ 08903 USA.
C3 Louisiana State University System; Louisiana State University; Rutgers
   University System; Rutgers University New Brunswick
RP Stephens, JM (corresponding author), Louisiana State Univ, Dept Biol Sci, 202 Life Sci Bldg, Baton Rouge, LA 70803 USA.
EM jsteph1@lsu.edu
RI Stephens, Jacqueline/R-5217-2018
FU NCCIH NIH HHS [P50 AT002776] Funding Source: Medline; NIDDK NIH HHS [R01
   DK052968] Funding Source: Medline
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NR 14
TC 13
Z9 15
U1 0
U2 3
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0006-291X
EI 1090-2104
J9 BIOCHEM BIOPH RES CO
JI Biochem. Biophys. Res. Commun.
PD OCT 9
PY 2009
VL 388
IS 1
BP 146
EP 149
DI 10.1016/j.bbrc.2009.07.137
PG 4
WC Biochemistry & Molecular Biology; Biophysics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics
GA 555SH
UT WOS:000274534200029
PM 19646953
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Chedraui, P
   Pérez-López, FR
AF Chedraui, P.
   Perez-Lopez, F. R.
TI Nutrition and health during mid-life: searching for solutions and
   meeting challenges for the aging population
SO CLIMACTERIC
LA English
DT Article
DE AGING; MEDITERRANEAN LIFESTYLE; OLIVE OIL; CALORIC RESTRICTION;
   SIRTUINS; POLYUNSATURATED FATTY ACIDS; POLYPHENOLS; FLAVONOIDS; PHYSICAL
   ACTIVITY
ID MEDITERRANEAN DIET; CARDIOVASCULAR-DISEASE; VASOMOTOR SYMPTOMS;
   LIFE-STYLE; OLIVE OIL; VEGETABLE CONSUMPTION; POSTMENOPAUSAL WOMEN;
   CALORIC RESTRICTION; PHYSICAL-EXERCISE; FLAVONOID INTAKE
AB Interactions between genetic (genome) and environmental factors (epigenome) operate during a person's entire lifespan. The aging process is associated with several cellular and organic functional alterations that, at the end, cause multi-organic cell failure. Epigenetic mechanisms of aging are modifiable by appropriate preventive actions mediated by sirtuins, caloric input, diet components, adipose tissue-related inflammatory reactions, and physical activity. The Mediterranean lifestyle has been for many millennia a daily habit for people in Western civilizations living around the Mediterranean sea who worked intensively and survived with very few seasonal foods. A high adherence to the traditional Mediterranean diet is associated with low mortality (higher longevity) and reduced risk of developing chronic diseases, including cancer, the metabolic syndrome, depression and cardiovascular and neurodegenerative diseases. Reports indicate that some dietary components, such as olive oil, antioxidants, omega-3 and -6 polyunsaturated acids, polyphenols and flavonoids, mediate beneficial anti-aging effects (anti-chronic diseases and increased longevity). Equally, physical activity displays a positive effect, producing caloric consumption and regulation of adipose and pancreatic function. The predictive strength of some food patterns may be a way of developing recommendations for food and health policies. This paper will discuss several ways of improving health during mid-life, focusing on certain groups of functional foods and healthy habits which may reduce or prevent age-related chronic diseases.
C1 [Chedraui, P.] Univ Catolica Santiago Guayaquil, Fac Med, Res Area Womens Hlth, Inst Biomed, Guayaquil, Ecuador.
   [Perez-Lopez, F. R.] Univ Zaragoza, Inst Aragones Ciencias Salud, Hosp Clin Lozano Blesa, Zaragoza, Spain.
C3 University of Zaragoza; Lozano Blesa University Clinical Hospital
RP Chedraui, P (corresponding author), Univ Catolica Santiago Guayaquil, Fac Ciencias Med, Res Area Womens Hlth, Inst Biomed, POB 09-01-4671, Guayaquil, Ecuador.
RI Blümel, Juan Enrique/JUV-6950-2023
OI Perez-Lopez, Faustino R./0000-0002-2801-416X
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NR 87
TC 30
Z9 33
U1 0
U2 54
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1369-7137
EI 1473-0804
J9 CLIMACTERIC
JI Climacteric
PD AUG
PY 2013
VL 16
SU 1
BP 85
EP 95
DI 10.3109/13697137.2013.802884
PG 11
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA 183BB
UT WOS:000321787500012
PM 23651240
DA 2025-06-11
ER

PT J
AU Bransfield, RC
   Gadila, SKG
   Kursawe, LJ
   Dwork, AJ
   Rosoklija, G
   Horn, EJ
   Cook, MJ
   Embers, ME
AF Bransfield, Robert C.
   Gadila, Shiva Kumar Goud
   Kursawe, Laura J.
   Dwork, Andrew J.
   Rosoklija, Gorazd
   Horn, Elizabeth J.
   Cook, Michael J.
   Embers, Monica E.
TI Late-stage borreliosis and substance abuse
SO HELIYON
LA English
DT Article
DE Addiction; Drug abuse; Homicide; Suicide; Lyme disease; Persistent lyme
   disease; Phencyclidine; Post treatment lyme disease; Tick -borne
   relapsing fever; Borreliosis
ID IN-SITU HYBRIDIZATION; TARGETED OLIGONUCLEOTIDE PROBES; LYME-DISEASE
   DIAGNOSES; BIPOLAR DISORDER; METABOLIC SYNDROME; RELAPSING FEVER;
   UNITED-STATES; SCHIZOPHRENIA; MIYAMOTOI; MORTALITY
AB Background: Infectious diseases can contribute to substance abuse. Here, a fatal case of borreliosis and substance abuse is reported. This patient had a history of multiple tick bites and increasing multisystem symptoms, yet diagnosis and treatment were delayed. He experimented with multiple substances including phencyclidine (PCP), an N-methyl-D-aspartate (NMDA) receptor antagonist that opposes NMDA agonism caused by Borrelia infection. During PCP withdrawal, he committed one homicide, two assaults, and suicide. Methods: Brain tissue was obtained from autopsy and stained for microglial activation and quinolinic acid (QA). Immunoflouresence (IFA) and fluorescence in situ hybridization (FISH) were used to identify the presence of pathogens in autopsy tissue. Results: Autopsy tissue evaluation demonstrated Borrelia in the pancreas by IFA and heart by IFA and FISH. Activated microglia and QA were found in the brain, indicating neuroinflammation. It is postulated that PCP withdrawal may exacerbate symptoms produced by Borrelia-induced biochemical imbalances in the brain. This combination may have greatly increased his acute homicidal and suicidal risk. Patient databases also demonstrated the risk of homicide or suicide in patients diagnosed with borreliosis and confirmed multiple symptoms in these patients, including chronic pain, anxiety, and anhedonia. Conclusions: Late-stage borreliosis is associated with multiple symptoms that may contribute to an increased risk of substance abuse and addictive disorders. More effective diagnosis and treatment of borreliosis, and attention to substance abuse potential may help reduce associated morbidity and mortality in patients with borreliosis, particularly in endemic areas.
C1 [Bransfield, Robert C.] Rutgers RWJ Med Sch, Piscataway, NJ USA.
   [Bransfield, Robert C.] Hackensack Meridian Hlth Sch Med, Nutley, NJ USA.
   [Gadila, Shiva Kumar Goud; Embers, Monica E.] Tulane Univ Hlth Sci, Tulane Natl Primate Res Ctr, Div Immunol, Covington, LA 70433 USA.
   [Kursawe, Laura J.] Charite Univ Med Berlin, Charite Pl 1, D-10117 Berlin, Germany.
   [Kursawe, Laura J.] Free Univ Berlin, Charite Pl 1, D-10117 Berlin, Germany.
   [Kursawe, Laura J.] Humboldt Univ, Charite Pl 1, D-10117 Berlin, Germany.
   [Dwork, Andrew J.] Columbia Univ, Dept Psychiat, New York, NY USA.
   [Dwork, Andrew J.] Div Mol Imaging & Neuropathol, New York, NY USA.
   [Dwork, Andrew J.; Rosoklija, Gorazd; Cook, Michael J.] State Psychiat Inst, New York, NY USA.
   [Dwork, Andrew J.] Macedonian Acad Sci & Arts, Skopje, North Macedonia.
   [Dwork, Andrew J.; Rosoklija, Gorazd] Columbia Univ, Dept Pathol & Cell Biol, New York, NY USA.
   [Horn, Elizabeth J.] Lyme Dis Biobank, Portland, OR USA.
C3 Rutgers University System; Rutgers University New Brunswick; Rutgers
   University Biomedical & Health Sciences; Tulane University; Berlin
   Institute of Health; Free University of Berlin; Humboldt University of
   Berlin; Charite Universitatsmedizin Berlin; Free University of Berlin;
   Humboldt University of Berlin; Columbia University; New York State
   Psychiatry Institute; Columbia University
RP Embers, ME (corresponding author), Tulane Univ Hlth Sci, Tulane Natl Primate Res Ctr, Div Immunol, Covington, LA 70433 USA.
EM robert.bransfield@hmhn.org; ajd6@cumc.columbia.edu;
   info@lymebiobank.org; mcook98@msn.com; members@tulane.edu
RI Embers, Monica/JZT-8657-2024; Bransfield, Robert/J-7768-2019
FU Bay Area Lyme (BAL) Foundation; TNPRC P51 Base Grant [P51OD011104, RRID:
   SCR_008167]; Lyme Disease Biobank (LDB) - Steven and Alexandra Cohen
   Foundation
FX ME received funding from Bay Area Lyme (BAL) Foundation and the TNPRC
   P51 Base Grant. P51OD011104, RRID: SCR_008167. AD received funding from
   Lyme Disease Biobank (LDB) . LDB is funded by BAL, the Steven and
   Alexandra Cohen Foundation, and an anonymous donor.
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NR 80
TC 0
Z9 0
U1 0
U2 0
PU CELL PRESS
PI CAMBRIDGE
PA 50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA
EI 2405-8440
J9 HELIYON
JI Heliyon
PD MAY 30
PY 2024
VL 10
IS 10
AR e31159
DI 10.1016/j.heliyon.2024.e31159
EA MAY 2024
PG 12
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA TJ0O7
UT WOS:001240781400001
PM 38779029
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Herouvi, D
   Soldatou, A
   Paschou, SA
   Kalpia, C
   Karanasios, S
   Karavanaki, K
AF Herouvi, Despina
   Soldatou, Alexandra
   Paschou, Stavroula A.
   Kalpia, Christina
   Karanasios, Spyridon
   Karavanaki, Kyriaki
TI Bariatric surgery in the management of childhood and adolescence obesity
SO ENDOCRINE
LA English
DT Review
DE Childhood obesity; Adolescence obesity; Co morbidities; Bariatric
   surgery
ID LAPAROSCOPIC SLEEVE GASTRECTOMY; Y GASTRIC BYPASS; FOLLOW-UP;
   SINGLE-CENTER; WEIGHT-LOSS; CHILDREN; CONSEQUENCES; GUIDELINES; RISK
AB Background Nowadays, childhood obesity is literally a global pandemic health problem. According to current data, pediatric obesity is strongly associated with adult excess weight status as well as the development of certain co morbidities, already present in childhood, including cardiovascular disorders (dyslipidemia, hypertension), endocrine/metabolic (Type 2 diabetes, fatty liver disease, metabolic syndrome), respiratory, gastrointestinal, and musculoskeletal problems. Additionally, children with obesity frequently experience psychosocial issues, such as mood disorders, anxiety, prejudice and low self-esteem. Methods and results The aim of this article was to evaluate whether or not bariatric surgery is an effective and safe treatment option for childhood obesity. This paper is based on a literature search in Pub Med for articles referring to the medical co morbidities and the results of different types of bariatric surgery for the treatment of childhood obesity (up to 18 years) until December 2021. The following keywords were used as MESH terms: childhood obesity, adolescence obesity, co morbidities and bariatric surgery. The bibliographic references of the studies found in these databases were also reviewed. Conclusion Although some researchers demonstrate that surgical interventions in adolescents might be a reliable intervention to lose weight in a maintainable way and reverse many of the co morbidities associated with severe obesity, their safety and long-term efficacy are still not clarified. Thus, large long-term prospective studies, with detailed recording of complications and co morbidity resolution are obviously needed in order to determine the role of surgical treatment in childhood obesity.
C1 [Herouvi, Despina; Soldatou, Alexandra; Kalpia, Christina; Karanasios, Spyridon; Karavanaki, Kyriaki] Natl & Kapodistrian Univ Athens, Med Sch, P&A Kyriakou Childrens Hosp, Dept Pediat 2,Diabet & Metab Clin, Athens, Greece.
   [Paschou, Stavroula A.] Natl & Kapodistrian Univ Athens, Alexandra Hosp, Sch Med, Endocrine Unit,Dept Clin Therapeut, Athens, Greece.
   [Paschou, Stavroula A.] Natl & Kapodistrian Univ Athens, Alexandra Hosp, Sch Med, Diabet Ctr,Dept Clin Therapeut, Athens, Greece.
C3 National & Kapodistrian University of Athens; National & Kapodistrian
   University of Athens; Alexandra Hospital; Athens Medical School;
   Alexandra Hospital; National & Kapodistrian University of Athens; Athens
   Medical School
RP Herouvi, D (corresponding author), Natl & Kapodistrian Univ Athens, Med Sch, P&A Kyriakou Childrens Hosp, Dept Pediat 2,Diabet & Metab Clin, Athens, Greece.
EM d.herouvi@gmail.com
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NR 68
TC 2
Z9 3
U1 1
U2 5
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1355-008X
EI 1559-0100
J9 ENDOCRINE
JI Endocrine
PD MAR
PY 2023
VL 79
IS 3
BP 411
EP 419
DI 10.1007/s12020-022-03210-9
EA OCT 2022
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 9P2NY
UT WOS:000864227200004
PM 36194346
DA 2025-06-11
ER

PT J
AU Reininghaus, B
   Riedrich, K
   Dalkner, N
   Lehner, LA
   Rieger, A
   Hamm, C
   Dorn, M
   Gradauer, L
   Hufnagl, A
   Mayr-Mauhart, M
   Miniberger, G
   Schachner, A
   Wagger, K
   Birner, A
   Platzer, M
   Fellendorf, F
   Queissner, R
   Bengesser, S
   Reininghaus, E
AF Reininghaus, Bernd
   Riedrich, Karin
   Dalkner, Nina
   Lehner, Laura Antonia
   Rieger, Alexandra
   Hamm, Carlo
   Dorn, Matthias
   Gradauer, Leopold
   Hufnagl, Alois
   Mayr-Mauhart, Markus
   Miniberger, Guenther
   Schachner, Andrea
   Wagger, Katharina
   Birner, Armin
   Platzer, Martina
   Fellendorf, Frederike
   Queissner, Robert
   Bengesser, Susanne
   Reininghaus, Eva
TI Physical health in individuals with psychiatric disorders in Austria
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Somatic comorbidities; Cardiovascular diseases; Obesity; Diabetes
   mellitus; Thyroid dysfunction; Bipolar disorder; Mental illness;
   Metabolism; Psychosomatic; Gender
ID CORONARY-HEART-DISEASE; BIPOLAR DISORDER; MEDICAL COMORBIDITY;
   PREVALENCE; MORTALITY; INTERVIEW; ADULTS; ILLNESS; PEOPLE; BURDEN
AB Introduction: The association between severe psychiatric disorders and metabolic syndrome is well documented and goes along with a reduced life expectancy. The prevalence of medical comorbidities in individuals suffering from psychiatric disorders in Austria has not yet been examined; aim of this study was to analyze the prevalence of comorbid somatic disorder in individuals diagnosed with psychiatric disorders in Austria.
   Methods: Patients (n = 600) with a life-time diagnosis of mood and anxiety disorders undergoing a six-week course of intensive treatment in a psychiatric rehabilitation center were recruited. Prevalent somatic and psychological conditions, anamnestic data, medical history, blood samples, clinical and psychological tests as well as medication were examined to determine somatic and psychiatric diagnoses.
   Results: Metabolic disorders were highly prevalent especially in individuals diagnosed with affective disorders, respectively in bipolar disorder. Furthermore, obesity and thyroid dysfunction were found in about 40% of individuals diagnosed with bipolar disorder in the present study. Significant gender differences were found in CVD and hypertension with higher prevalence in men, while thyroid dysfunction occurred more often in women also compared to the general female population.
   Conclusions: Characterizing somatic comorbidity in individuals with psychiatric disorders can stimulate research to better understand possible shared etiologic factors and has public health implications for improving models of care. This could have a positive effect on the course of mental disorders, and additionally improve social integration and life expectancy. Knowledge about sex differences should be used to further improve individualized treatment of individuals with psychiatric disorders.
C1 [Reininghaus, Bernd; Riedrich, Karin; Lehner, Laura Antonia; Rieger, Alexandra; Hamm, Carlo; Dorn, Matthias; Gradauer, Leopold; Hufnagl, Alois; Mayr-Mauhart, Markus; Miniberger, Guenther; Schachner, Andrea; Wagger, Katharina] Therapiezentrum Justuspk, A-4540 Bad Hall, Austria.
   [Reininghaus, Bernd; Riedrich, Karin; Dalkner, Nina; Rieger, Alexandra; Hamm, Carlo; Birner, Armin; Platzer, Martina; Fellendorf, Frederike; Queissner, Robert; Bengesser, Susanne; Reininghaus, Eva] Med Univ Graz, Dept Psychiat & Psychotherapeut Med, Auenbruggerpl 31, A-8036 Graz, Austria.
C3 Medical University of Graz
RP Dalkner, N (corresponding author), Med Univ Graz, Dept Psychiat & Psychotherapeut Med, Auenbruggerpl 31, A-8036 Graz, Austria.
EM Nina.dalkner@medunigraz.at
OI Fellendorf, Frederike/0000-0001-7215-3848
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NR 43
TC 10
Z9 11
U1 0
U2 19
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD OCT 1
PY 2019
VL 257
BP 38
EP 44
DI 10.1016/j.jad.2019.06.045
PG 7
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA IS8CQ
UT WOS:000482376300006
PM 31299403
DA 2025-06-11
ER

PT J
AU Kim, EY
   Lee, MY
   Kim, SH
   Ha, K
   Kim, KP
   Ahn, YM
AF Kim, Eun Young
   Lee, Min Young
   Kim, Se Hyun
   Ha, Kyooseob
   Kim, Kwang Pyo
   Ahn, Yong Min
TI Diagnosis of major depressive disorder by combining multimodal
   information from heart rate dynamics and serum proteomics using
   machine-learning algorithm
SO PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
LA English
DT Article
DE Major depressive disorder; Biomarker; Proteomics; Heart rate
   variability; Machine-learning
ID RATE-VARIABILITY; METABOLIC SYNDROME; MORTALITY; CLASSIFICATION;
   COMPLEXITY; INVENTORY; SELECTION; PREDICTS; ENTROPY; ANXIETY
AB Objective: Major depressive disorder (MDD) is a systemic and multifactorial disorder that involves abnormalities in multiple biochemical pathways and the autonomic nervous system. This study applied a machine-learning method to classify MDD and control groups by incorporating data from serum proteomic analysis and heart rate variability (HRV) analysis for the identification of novel peripheral biomarkers.
   Methods: The study subjects consisted of 25 drug-free female MDD patients and 25 age-and sex-matched healthy controls. First, quantitative serum proteome profiles were analyzed by liquid chromatography-tandem mass spectrometry using pooled serum samples from 10 patients and 10 controls. Next, candidate proteins were quantified with multiple reaction monitoring (MRM) in 50 subjects. We also analyzed 22 linear and nonlinear HRV parameters in 50 subjects. Finally, we identified a combined biomarker panel consisting of proteins and HRV indexes using a support vector machine with recursive feature elimination.
   Results: A separation between MDD and control groups was achieved using five parameters (apolipoprotein B, group-specific component, ceruloplasmin, RMSSD, and SampEn) at 80.1% classification accuracy. A combination of HRV and proteomic data achieved better classification accuracy.
   Conclusions: A high classification accuracy can be achieved by combining multimodal information from heart rate dynamics and serum proteomics in MDD. Our approach can be helpful for accurate clinical diagnosis of MDD. Further studies using larger, independent cohorts are needed to verify the role of these candidate biomarkers for MDD diagnosis. (C) 2017 Elsevier Inc. All rights reserved.
C1 [Kim, Eun Young] Seoul Natl Univ Hosp, Dept Med, Seoul, South Korea.
   [Lee, Min Young] Inst Syst Biol, Seattle, WA USA.
   [Lee, Min Young; Kim, Kwang Pyo] Kyung Hee Univ, Coll Appl Sci, Dept Appl Chem, Yongin, South Korea.
   [Kim, Se Hyun] Dongguk Univ, Int Hosp, Med Sch, Dept Neuropsychiat, Goyang, South Korea.
   [Ha, Kyooseob; Ahn, Yong Min] Seoul Natl Univ, Coll Med, Inst Human Behav Med, Seoul, South Korea.
   [Ha, Kyooseob; Ahn, Yong Min] Seoul Natl Univ Hosp, Dept Psychiat, Seoul, South Korea.
C3 Seoul National University (SNU); Seoul National University Hospital;
   Institute for Systems Biology (ISB); Kyung Hee University; Dongguk
   University; Seoul National University (SNU); Seoul National University
   (SNU); Seoul National University Hospital
RP Ahn, YM (corresponding author), Seoul Natl Univ, Coll Med, Inst Human Behav Med, Dept Psychiat & Behav Sci, 28 Yongon Dong, Seoul 110744, South Korea.
EM aym@snu.ac.kr
RI Ha, Kyooseob/J-5698-2012; Kim, Kyung/F-3470-2010; Kim, Kwang
   Pyo/AAG-1815-2020
OI Ha, Kyooseob/0000-0001-5035-2950; Kim, Kwang Pyo/0000-0003-0095-3787
FU Korea Healthcare Technology R & D Project, Ministry of Health and
   Welfare, Republic of Korea [A121987]
FX This work was supported by the Korea Healthcare Technology R & D
   Project, Ministry of Health and Welfare, Republic of Korea (grant number
   A121987).
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NR 57
TC 29
Z9 34
U1 0
U2 38
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0278-5846
EI 1878-4216
J9 PROG NEURO-PSYCHOPH
JI Prog. Neuro-Psychopharmacol. Biol. Psychiatry
PD JUN 2
PY 2017
VL 76
BP 65
EP 71
DI 10.1016/j.pnpbp.2017.02.014
PG 7
WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA EY9LR
UT WOS:000404320600008
PM 28223106
DA 2025-06-11
ER

PT J
AU Johnsen, E
   Fathian, F
   Kroken, RA
   Steen, VM
   Jorgensen, HA
   Gjestad, R
   Loberg, EM
AF Johnsen, Erik
   Fathian, Farivar
   Kroken, Rune A.
   Steen, Vidar M.
   Jorgensen, Hugo A.
   Gjestad, Rolf
   Loberg, Else-Marie
TI The serum level of C-reactive protein (CRP) is associated with cognitive
   performance in acute phase psychosis
SO BMC PSYCHIATRY
LA English
DT Article
DE Schizophrenia; Cognition; Inflammation; CRP
ID NEUROPSYCHOLOGICAL STATUS; REPEATABLE BATTERY; CIGARETTE-SMOKING;
   NEUROCOGNITIVE DEFICITS; COMPLEMENT ACTIVATION; LONGITUDINAL COURSE;
   METABOLIC SYNDROME; SCHIZOPHRENIA; RISK; INFLAMMATION
AB Background: Inflammatory processes have been implicated in the etiology of schizophrenia and related psychoses, in which cognitive deficits represent core symptoms. The aim of the present study was to investigate possible associations between the level of the inflammation marker C-reactive protein (CRP) and cognitive performance in patients through the acute phase of psychosis.
   Methods: A total of 124 patients were assessed at admittance to hospital and 62 patients were retested at discharge or after 6 weeks at the latest, with measurements of the CRP levels and alternative forms of the Repeatable Battery for the Assessment of Neuropsychological Status.
   Results: There was an inverse relationship between overall cognitive performance and CRP level at admittance. The association increased in sub-analyses including only patients with schizophrenia. In cognitive subdomain analyses statistically significant inverse associations were found between the CRP level and Delayed memory and Attention, respectively. No associations were found between CRP level and other measures of psychopathology including psychosis symptoms, depression, or functioning. At follow-up the association between CRP level and cognition was no longer present. There was a significant increase in cognitive performance between baseline and follow-up. There was a stronger increase in overall cognition scores in patients with higher baseline CRP levels.
   Conclusions: The findings indicate that signs of inflammation may serve as a state-dependent marker of cognitive dysfunctions in acute psychosis.
C1 [Johnsen, Erik; Kroken, Rune A.; Gjestad, Rolf] Haukeland Hosp, Div Psychiat, N-5021 Bergen, Norway.
   [Johnsen, Erik; Kroken, Rune A.; Jorgensen, Hugo A.] Univ Bergen, Sect Psychiat, Dept Clin Med, Bergen, Norway.
   [Fathian, Farivar] NKS Olaviken Gerontopsychiat Hosp, Bergen, Norway.
   [Steen, Vidar M.] Univ Bergen, Dept Clin Sci, NORMENT & KG Jebsen Ctr Psychosis Res, Bergen, Norway.
   [Steen, Vidar M.] Haukeland Hosp, Dr Einar Martens Res Grp Biol Psychiat, Ctr Med Genet & Mol Med, N-5021 Bergen, Norway.
   [Loberg, Else-Marie] Univ Bergen, Dept Clin Psychol, Bergen, Norway.
   [Loberg, Else-Marie] Haukeland Hosp, Dept Addict Med, N-5021 Bergen, Norway.
C3 University of Bergen; Haukeland University Hospital; University of
   Bergen; University of Bergen; University of Bergen; Haukeland University
   Hospital; University of Bergen; University of Bergen; Haukeland
   University Hospital
RP Johnsen, E (corresponding author), Haukeland Hosp, Div Psychiat, N-5021 Bergen, Norway.; Johnsen, E (corresponding author), Univ Bergen, Sect Psychiat, Dept Clin Med, Bergen, Norway.
EM erij@ihelse.net
RI Steen, Vidar/A-6190-2008
OI Kroken, Rune/0000-0002-0903-3840
FU Research Council of Norway [213727]; Helse Vest RHF [911679]; KG Jebsen
   Foundation; Research Council of Norway through Centres of Excellence
   [223273]; Academy of Finland (AKA) [213727] Funding Source: Academy of
   Finland (AKA)
FX Funding of the project was provided by grants to EJ from the Research
   Council of Norway (#213727) and Helse Vest RHF (#911679), and partly
   supported by the KG Jebsen Foundation and the Research Council of Norway
   through its Centres of Excellence funding scheme (#223273). The funding
   sources had no role in the study design; in collection, analyses and
   interpretation of data; in the writing of the report; or in the decision
   to submit the paper for publication.
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NR 81
TC 56
Z9 59
U1 1
U2 17
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-244X
J9 BMC PSYCHIATRY
JI BMC Psychiatry
PD MAR 14
PY 2016
VL 16
AR 60
DI 10.1186/s12888-016-0769-x
PG 11
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychiatry
GA DG1YC
UT WOS:000371862400001
PM 26973142
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Lidstone, JSM
   Ells, LJ
   Finn, P
   Whittaker, VJ
   Wilkinson, JR
   Summerbell, CD
AF Lidstone, JSM
   Ells, LJ
   Finn, P
   Whittaker, VJ
   Wilkinson, JR
   Summerbell, CD
TI Independent associations between weight status and disability in adults:
   Results from the health survey for England
SO PUBLIC HEALTH
LA English
DT Article
DE obesity; morbid obesity; overweight; disability; population survey
ID BODY-MASS INDEX; METABOLIC SYNDROME; OBESITY; DEPRESSION; RISK
AB Objectives: While direct links between obesity and some illnesses are well-established, there is a relative paucity of research on associations between obesity and disabilities. The aim of this study was to test for significant associations between overweight and obesity and the presence of a wide range of disabling conditions in adults, controlling for sex, age, education, social class, income, cigarette smoking status and alcohol consumption.
   Study design: Data were extracted from the Health Survey for England (2001); a cross-sectional survey of the community-dwelling population. In total, 8613 adult participants were included in the analysis.
   Methods: Multivariate logistic regression was employed to test whether the odds of having a range of disabling conditions are higher in the overweight and obese populations compared with those in the ideal weight range.
   Results: The risk of nearly all disabling conditions tested was elevated in the obese and morbidly obese groups. Of great importance for public health, the risks of musculoskeletal illness, arthritis and rheumatism, and personal care disability were significantly elevated, even in those in the overweight category (currently about half of the adult population living in the UK).
   Conclusions: Obesity is independently associated with a range of disabling conditions in adults. The present study highlights the need for further research into the mechanisms by which these associations occur. (c) 2006 Published by Elsevier Ltd on behalf of The Royal Institute of Public Health.
C1 Univ Teesside, Sch Hlth & Social Care, Middlesbrough TS1 3BA, Cleveland, England.
   Univ Durham, NE Publ Hlth Observ, Stockton On Tees, England.
C3 University of Teesside; Durham University
RP Lidstone, JSM (corresponding author), Univ Teesside, Sch Hlth & Social Care, Middlesbrough TS1 3BA, Cleveland, England.
EM j.lidstone@tees.ac.uk
RI ; Summerbell, Carolyn/O-3759-2015
OI Ells, Louisa/0000-0003-0559-4832; Summerbell,
   Carolyn/0000-0003-1910-9383; Whittaker, Vicki/0009-0006-4449-0090
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NR 23
TC 34
Z9 37
U1 0
U2 3
PU W B SAUNDERS CO LTD
PI LONDON
PA 32 JAMESTOWN RD, LONDON NW1 7BY, ENGLAND
SN 0033-3506
J9 PUBLIC HEALTH
JI Public Health
PD MAY
PY 2006
VL 120
IS 5
BP 412
EP 417
DI 10.1016/j.puhe.2005.12.003
PG 6
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA 049LR
UT WOS:000238018400005
PM 16566950
DA 2025-06-11
ER

PT S
AU Perrone, MG
   Scilimati, A
AF Perrone, Maria Grazia
   Scilimati, Antonio
BE Conn, PM
TI β3-ADRENOCEPTOR AGONISTS AND (ANTAGONISTS AS) INVERSE
   AGONISTS: HISTORY, PERSPECTIVE, CONSTITUTIVE ACTIVITY, AND
   STEREOSPECIFIC BINDING
SO METHODS IN ENZYMOLOGY, VOLUME 484: CONSTITUTIVE ACTIVITY IN RECEPTORS
   AND OTHER PROTEINS, PART A
SE Methods in Enzymology
LA English
DT Review; Book Chapter
ID ADRENERGIC-RECEPTOR AGONISTS; ATYPICAL BETA-ADRENOCEPTORS; OCCUPANCY
   MODEL; BLOOD-FLOW; SR 58611A; POTENT; EXPRESSION; EFFICACY;
   IDENTIFICATION; ENHANCEMENT
AB beta(3)-Adrenergic receptor (beta(3)-AR) is expressed in several tissues and is considered a drug target for the treatment of several pathologies such as obesity, type 2 diabetes, cachexia, metabolic syndrome, heart failure, anxiety and depressive disorders, preterm labor, overactive bladder, control colon motility, and of coadjuvants in colon cancer therapy. It is a seven-transmembrane domain (7TD) G-protein coupled receptor and is usually coupled to a Gs-protein (Gi-protein in very few cases), and its stimulation increases the production of cAMP. A lot of beta(3)-AR agonists have been uncovered and extensively characterized. Conversely, very little is known about beta(3)-AR inverse agonists that would suppress the agonist-independent activity (constitutive activity) of the receptor by stabilizing it in its inactive state. This chapter attempts to outline (a) the importance of the beta(3)-AR as a therapeutic target through the disquisition of its role in human health (physiology) and disease (pathology); (b) the description of beta(3)-AR structure [amino acid sequence and 7TD organization]; (c) the medicinal chemistry of beta(3)-AR: 7TD amino acid-ligand specific interactions, beta-adrenoreceptor subtype selectivity, stereospecific interactions and biological activity relationships, inverse agonism and blockage of beta(3)-adrenoceptor constitutive activity; and (d) beta(3)-AR inverse agonists. The detailed procedure to prepare and assess the biological activity/selectivity of the more potent and selective beta(3)-AR inverse agonists (SP-1e and SP-1g) up to now known is also described.
C1 [Perrone, Maria Grazia; Scilimati, Antonio] Univ Bari A Moro, Dept Med Chem, Bari, Italy.
C3 Universita degli Studi di Bari Aldo Moro
RP Perrone, MG (corresponding author), Univ Bari A Moro, Dept Med Chem, Bari, Italy.
OI Scilimati, Antonio/0000-0003-2740-6425; Perrone, Maria
   Grazia/0000-0003-4195-5228
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NR 72
TC 16
Z9 16
U1 0
U2 4
PU ELSEVIER ACADEMIC PRESS INC
PI SAN DIEGO
PA 525 B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0076-6879
BN 978-0-12-381298-8
J9 METHOD ENZYMOL
JI Methods Enzymol.
PY 2010
VL 484
BP 197
EP 230
DI 10.1016/S0076-6879(10)84011-X
PG 34
WC Biochemical Research Methods; Biochemistry & Molecular Biology
WE Book Citation Index – Science (BKCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA BSI07
UT WOS:000284508500011
PM 21036234
DA 2025-06-11
ER

PT J
AU Musil, R
   Obermeier, M
   Russ, P
   Hamerle, M
AF Musil, Richard
   Obermeier, Michael
   Russ, Paul
   Hamerle, Michael
TI Weight gain and antipsychotics: a drug safety review
SO EXPERT OPINION ON DRUG SAFETY
LA English
DT Review
DE amisulpride; aripiprazole; asenapine; clozapine; first-generation
   antipsychotic agents; haloperidol; iloperidone; lurasidone; olanzapine;
   paliperidone; quetiapine; risperidone; second-generation antipsychotic
   agents; sertindole; weight gain; ziprasidone
ID PALIPERIDONE EXTENDED-RELEASE; BIPOLAR I DISORDER; FUMARATE QUETIAPINE
   XR; MAJOR DEPRESSIVE DISORDER; ACTING INJECTABLE RISPERIDONE;
   GENERALIZED ANXIETY DISORDER; RANDOMIZED CONTROLLED-TRIAL;
   PLACEBO-CONTROLLED TRIAL; LONG-TERM TREATMENT; BODY-MASS INDEX
AB Introduction: Second-generation antipsychotics (SGAs) are widely used in several psychiatric disease entities and exert to a different extent a risk for antipsychotic-induced weight gain (AIWG). As AIWG is associated with an increase in metabolic syndrome or cardiovascular events, knowledge of these risks is crucial for further monitoring and the initiation of counteractive measures.
   Areas covered: We searched PubMed and Web of Sciences for randomized-controlled trials and naturalistic observational studies published between 2010 and 2014 with sample sizes exceeding 100, including all marketed SGAs apart from zotepine, and providing data on weight increase. We also summarized relevant systematic reviews and meta-analyses of head-to-head comparisons.
   Expert opinion: Recently published data still support the hierarchical ranking of SGAs already proposed in previous reviews ranking clozapine and olanzapine as having the highest risk, followed by amisulpride, asenapine, iloperidone, paliperidone, quetiapine, risperidone and sertindole in the middle, and aripiprazole, lurasidone and ziprasidone with the lowest risk. Number needed to harm varied considerably in our meta-analysis. Younger patients and patients with a lower baseline body mass index are most vulnerable. The greatest amount of weight gain occurs within the first weeks of treatment. AIWG occurs in all diagnostic groups and is also common in treatment with first-generation antipsychotics; therefore, awareness of this adverse event is essential for anyone prescribing antipsychotics.
C1 [Musil, Richard; Hamerle, Michael] Univ Munich, Dept Psychiat & Psychotherapy, D-80336 Munich, Germany.
   [Obermeier, Michael] Gesell Therapieforsch mbH, GKM, D-80336 Munich, Germany.
   [Russ, Paul] Univ Munich, Krankenhaus Neuwittelsbach, Dept Internal Med, D-80639 Munich, Germany.
C3 University of Munich; University of Munich
RP Musil, R (corresponding author), Univ Munich, Dept Psychiat & Psychotherapy, Nussbaumstr 7, D-80336 Munich, Germany.
EM Richard.musil@med.uni-muenchen.de
RI Musil, Richard/AAF-4331-2020
FU AstraZeneca; Janssen-Cilag
FX The authors declare that over the past 3 years author R Musil has
   received research support from AstraZeneca and Janssen-Cilag. He has
   been on the advisory board of Roche Pharmaceuticals. The authors have no
   other relevant affiliations or financial involvement with any
   organization or entity with a financial interest in or financial
   conflict with the subject matter or materials discussed in the
   manuscript. This includes employment, consultancies, honoraria, stock
   ownership or options, expert testimony, grants or patents received or
   pending, or royalties.
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NR 192
TC 130
Z9 140
U1 0
U2 46
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1474-0338
EI 1744-764X
J9 EXPERT OPIN DRUG SAF
JI Expert Opin. Drug Saf.
PD JAN
PY 2015
VL 14
IS 1
BP 73
EP 96
DI 10.1517/14740338.2015.974549
PG 24
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA AW6ZL
UT WOS:000346414100007
PM 25400109
DA 2025-06-11
ER

PT J
AU Trovato, E
   Dragotto, M
   Capalbo, E
   Cartocci, A
   Rubegni, P
   Calabrese, L
AF Trovato, Emanuele
   Dragotto, Martina
   Capalbo, Eugenio
   Cartocci, Alessandra
   Rubegni, Pietro
   Calabrese, Laura
TI Uncovering the Differences: How DLQI and WHO-5 Scores Vary in
   Moderate-to-Severe Psoriasis Patients Treated with Tildrakizumab 100 mg
   vs. 200 mg?
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Article
DE biologics; psoriasis; quality of life; tildrakizumab; patient-reported
   outcomes; DLQI; WHO-5
ID QUALITY INDEX DLQI; PLAQUE PSORIASIS; ETANERCEPT; BURDEN
AB Background/Objectives: Psoriasis (PsO) is a chronic inflammatory skin disease that severely impacts patients' quality of life (QoL). Its global prevalence is about 2%, with significant regional variations. PsO manifests in the form of erythematous and scaly plaques, causing intense pruritus and discomfort and limiting daily activities. The condition often includes comorbidities such as psoriatic arthritis, cardiovascular diseases, and metabolic syndrome, further deteriorating QoL. Psychological well-being is notably affected, with high levels of depression and anxiety due to the visible lesions, leading to social stigma and isolation. QoL indexes like WHO-QoL and SF-36 assess various well-being aspects, while patient-reported outcomes (PROs) provide a comprehensive understanding of PsO's impact. However, there are no universally shared PROs in outpatient practice to fully understand the impact of the disease and associated therapies. This study aims to evaluate differences between DLQI and WHO-5 in adult patients with moderate-to-severe PsO treated with tildrakizumab 100 mg or 200 mg. Methods: The study was conducted at the University Hospital of Siena, Italy, from May 2023 to April 2024. Data from 15 patients treated with tildrakizumab 200 mg and 15 patients treated with tildrakizumab 100 mg, observed for at least 28 weeks, were recorded. Demographic data, PASI, DLQI, and WHO-5 scores were analyzed. Patients in the 100 mg group (G100) were selected to match the demographic characteristics of the 200 mg group (G200). Reduction rates of DLQI and WHO-5 were assessed at baseline values and after 4, 16, and 28 weeks. Results: Both groups experienced improvements in QoL. The group treated with 200 mg showed more pronounced and rapid reductions in DLQI and WHO-5 scores compared to the 100 mg group. WHO-5 demonstrated faster improvements in overall well-being than DLQI, indicating its greater sensitivity to changes in mental well-being and overall QoL. No differences in adverse events were observed between the two groups, with no major adverse events reported. Conclusions: In our study, WHO-5 proved more sensitive than DLQI in capturing well-being changes in PsO patients treated with tildrakizumab. However, a combined use of both WHO-5 and DLQI questionnaires should be encouraged in clinical practice. Furthermore, this study confirmed the superior QoL improvement associated with tildrakizumab 200 mg compared to 100 mg. Future research should explore the long-term impact on QoL and comparative effectiveness among other biologic therapies in diverse patient populations.
C1 [Trovato, Emanuele; Dragotto, Martina; Capalbo, Eugenio; Cartocci, Alessandra; Rubegni, Pietro; Calabrese, Laura] Univ Siena, Dept Med Surg & Neurol Sci, Dermatol Unit, I-53100 Siena, Italy.
   [Cartocci, Alessandra] Univ Siena, Dept Med Biotechnol, Siena 53100, Italy.
   [Calabrese, Laura] Univ Cattolica Sacro Cuore, Dipartimento Med & Chirurg Traslazionale, Dermatol, I-00168 Rome, Italy.
C3 University of Siena; University of Siena; Catholic University of the
   Sacred Heart; IRCCS Policlinico Gemelli
RP Calabrese, L (corresponding author), Univ Siena, Dept Med Surg & Neurol Sci, Dermatol Unit, I-53100 Siena, Italy.; Calabrese, L (corresponding author), Univ Cattolica Sacro Cuore, Dipartimento Med & Chirurg Traslazionale, Dermatol, I-00168 Rome, Italy.
EM trovato.ema@gmail.com; laura.calabrese@unisi.it
RI Calabrese, Laura/HLX-1893-2023; Cartocci, Alessandra/AAB-5831-2020
OI Cartocci, Alessandra/0000-0002-1818-6275; Dragotto,
   Martina/0009-0006-9441-3923; Calabrese, Laura/0000-0001-5238-2336;
   Trovato, Emanuele/0000-0001-8301-9206
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NR 36
TC 2
Z9 2
U1 2
U2 3
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD SEP
PY 2024
VL 13
IS 17
AR 5240
DI 10.3390/jcm13175240
PG 10
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA F6W1M
UT WOS:001311190800001
PM 39274452
OA gold
DA 2025-06-11
ER

PT J
AU Imprialos, KP
   Koutsampasopoulos, K
   Katsimardou, A
   Bouloukou, S
   Theodoulidis, I
   Themistoklis, M
   Doumas, M
AF Imprialos, Konstantinos P.
   Koutsampasopoulos, Konstantinos
   Katsimardou, Aleksandra
   Bouloukou, Sofia
   Theodoulidis, Iakovos
   Themistoklis, Mikos
   Doumas, Michael
TI Female Sexual Dysfunction: A Problem Hidden in the Shadows
SO CURRENT PHARMACEUTICAL DESIGN
LA English
DT Review
DE Female sexual dysfunction; hypertension; diabetes mellitus;
   dyslipidemia; cardiovascular disease; drug-related sexual dysfunc-tion;
   sexual dysfunction treatment
ID QUALITY-OF-LIFE; PREMENOPAUSAL WOMEN EFFICACY; POSTMENOPAUSAL WOMEN;
   DESIRE DISORDER; DIABETES-MELLITUS; PROVOKED VESTIBULODYNIA;
   URINARY-INCONTINENCE; METABOLIC SYNDROME; AROUSAL DISORDER; SOCIAL
   ANXIETY
AB Background: Female sexual dysfunction (FSD) has been largely underdiagnosed and undertreated due to the lack of concrete definitions, validated assessment methods and efficient treatments. However, during the last few decades, there has been great progress in the clinical management and research of FSD. Objective: The purpose of this review is to describe the pathophysiology of FSD, report the prevalence of the disease in the setting of cardiovascular (CV) risk factors and disease, and review current and under investigation treatment options. Methods: A comprehensive review was performed to identify studies examining the association of FSD with CV risk factors and/or disease, as well studies reporting relevant management options. Results: The prevalence of FSD is increased in the general population (approximately 40%) and is significantly higher in patients with hypertension, diabetes mellitus, and dyslipidemia. In patients with overt CV disease, FSD is even more prevalent (up to 90%). The cause of FSD is multifactorial and includes a variety of vascular, hormonal, interpersonal and psychological factors, which are all intertwined. Several treatment options exist that are efficient in improving female sexual function, while a cluster of other options has been shown to offer benefits. Conclusion: FSD is a major public health problem with great impact on the patients' quality of life. In the setting of increased CV burden, FSD is even more prevalent. Increased awareness is needed for the physician to establish a trustful environment with the patient, discuss such issues, and offer proper management options.
C1 [Imprialos, Konstantinos P.; Koutsampasopoulos, Konstantinos; Katsimardou, Aleksandra; Bouloukou, Sofia; Doumas, Michael] Aristotle Univ Thessaloniki, Hippokrat Hosp, Propaedeut Dept Internal Med 2, Med Sch, Thessaloniki, Greece.
   [Theodoulidis, Iakovos; Themistoklis, Mikos] Aristotle Univ Thessaloniki, Dept Obstet & Gynecol 1, Thessaloniki, Greece.
   [Doumas, Michael] VAMC, Washington, DC USA.
   [Doumas, Michael] George Washington Univ, Washington, DC USA.
C3 Aristotle University of Thessaloniki; Aristotle University of
   Thessaloniki; George Washington University
RP Doumas, M (corresponding author), Aristotle Univ Thessaloniki, Hippokrat Hosp, Propedeut Dept Internal Med 2, St Konstantinoupoleos 49, Thessaloniki 54642, Greece.
EM michalisdoumas@yahoo.co.uk
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   EMIRATES
SN 1381-6128
EI 1873-4286
J9 CURR PHARM DESIGN
JI Curr. Pharm. Design
PY 2021
VL 27
IS 36
BP 3762
EP 3774
DI 10.2174/1381612827666210719104950
PG 13
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA WJ8KW
UT WOS:000709288400003
PM 34554899
DA 2025-06-11
ER

PT J
AU Akanji, AO
   Ohaeri, JU
   Al-Shammri, S
   Fatania, HR
AF Akanji, Abayomi O.
   Ohaeri, Jude U.
   Al-Shammri, Suhail
   Fatania, Hasmukh R.
TI Association of blood levels of C-reactive protein with clinical
   phenotypes in Arab schizophrenic patients
SO PSYCHIATRY RESEARCH
LA English
DT Article
DE Arabs; Schizophrenia; CRP; Cytokines; Disease phenotypes; Metabolic
   syndrome
ID ELEVATED SERUM-LEVELS; CARDIOVASCULAR-DISEASE; RISK; INFLAMMATION;
   SYMPTOMS; INTERLEUKIN-6; HOMOCYSTEINE; PREDICTORS; DEPRESSION; COHORT
AB Schizophrenia may be associated with inflammatory reactions and C-reactive protein (CRP) is a nonspecific serum protein marker for persisting inflammatory states. This study aimed to assess concentrations of high sensitivity CRP (hsCRP) in schizophrenic Arab patients and evaluate the relationships of hsCRP levels with aspects of clinical phenotypes of the disease. Two age-matched groups of subjects were studied: (1) healthy controls, HC, n = 165; (2) patients with schizophrenia, SZ: n = 207. Each subject was evaluated with a standard questionnaire for age at disease onset, family history, disease severity and outcome. Serum hsCRP levels were measured by immunoassay. The two groups of subjects were similar in age, ethnic composition and socioeconomic status. Those with SZ had significantly greater serum concentrations of hsCRP. There were significant associations between hsCRP and (i) age in both groups: (ii) body mass index (BMI) in HC but not in SZ. In the latter, hsCRP levels were: (a) marginally higher in women with later age of disease onset; (ii) highest with remission and with catatonic features: and (iii) lower with family history of psychosis. The study concludes that serum levels of hsCRP are increased in clinically stable Arab patients with schizophrenia and appear related to the disorder's clinical expression. It is suggested that there may be an inflammatory component to schizophrenia which is associated with aspects of its clinical phenotype. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
C1 [Akanji, Abayomi O.] Kuwait Univ, Clin Chem Unit, Dept Pathol, Fac Med, Safat 13110, Kuwait.
   [Ohaeri, Jude U.] Psychol Med Hosp, Sulibikhat, Kuwait.
   [Al-Shammri, Suhail] Kuwait Univ, Dept Med, Fac Med, Safat 13110, Kuwait.
   [Fatania, Hasmukh R.] Kuwait Univ, Dept Biochem, Fac Med, Safat 13110, Kuwait.
C3 Kuwait University; Kuwait University; Kuwait University
RP Akanji, AO (corresponding author), Kuwait Univ, Clin Chem Unit, Dept Pathol, Fac Med, POB 24923, Safat 13110, Kuwait.
EM abayomi@hsc.edu.kw
RI Akanji, Abayomi/AAY-4732-2021
FU Kuwait University Research Administration [MG 02/02]
FX This study was supported by a Kuwait University Research Administration
   Grant # MG 02/02. We acknowledge the technical expertise of Dr Tarrik
   Zaid, Mr PK Shihab, Ms Arpita Bhattacharya and Ms Reema Mathew. The
   following individuals also played an invaluable role in psychiatric data
   collection: Anila Jacob, Maha EI-Taiyebani, Hani El-Shamali, Mohammed
   El-Dadiri, Rekha Kumar, and Fabine James.
CR AKANJI AO, 1997, J KUWAIT MED ASSOC, V29, P25
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NR 40
TC 53
Z9 55
U1 0
U2 8
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0165-1781
EI 1872-7123
J9 PSYCHIAT RES
JI Psychiatry Res.
PD AUG 30
PY 2009
VL 169
IS 1
BP 56
EP 61
DI 10.1016/j.psychres.2008.06.010
PG 6
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 489QW
UT WOS:000269437600011
PM 19619902
DA 2025-06-11
ER

PT J
AU Romo-Nava, F
   Blom, TJ
   Cuellar-Barboza, AB
   Winham, SJ
   Colby, CL
   Nunez, NA
   Biernacka, JM
   Frye, MA
   McElroy, SL
AF Romo-Nava, Francisco
   Blom, Thomas J.
   Cuellar-Barboza, Alfredo B.
   Winham, Stacey J.
   Colby, Colin L.
   Nunez, Nicolas A.
   Biernacka, Joanna M.
   Frye, Mark A.
   McElroy, Susan L.
TI Evening chronotype as a discrete clinical subphenotype in bipolar
   disorder
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Bipolar disorder; Chronotype; Comorbidity; Circadian; Hypertension;
   Suicide
ID MORNINGNESS-EVENINGNESS; CIRCADIAN PHASE; AFFECTIVE TEMPERAMENTS;
   METABOLIC SYNDROME; BODY-COMPOSITION; VALPROIC ACID; DOUBLE-BLIND;
   SLEEP; MOOD; MELATONIN
AB Objective: Our aim was to investigate evening chronotype, a proxy marker of circadian system dysfunction, as a clinical subphenotype in bipolar disorder (BD).
   Methods: In this cross-sectional study, 773 BD participants and 146 control subjects were evaluated using the Structured Clinical Interview for DSM-IV and a set of questionnaires. Chronotype was determined using item-5 from the reduced Morningness-Eveningness Questionnaire. Univariate analyses and regression models were used to compare evening and non-evening chronotype in BD and chronotype association with clinical variables.
   Results: Overall, 205 (27%) of BD patients reported an evening chronotype. Evening chronotype was higher in a matched sub-sample of BD patients (n = 150) than in controls (24% and 5% respectively, OR=5.4, p < 0.01). Compared to those with non-evening chronotypes, BD patients with an evening chronotype were younger, had an earlier age of onset of BD, and had more prior depressive and manic episodes, higher rates of rapid cycling, past suicide attempts, more comorbid anxiety and substance use disorders. Multivariate regression showed age, prior suicide attempts, and co-occurring substance use disorder were associated with evening chronotype (OR range of 0.97 to1.59). Hypertension, migraine, asthma, and obstructive sleep apnea were significantly associated with evening chronotype (OR range of 1.56 to 2.0).
   Limitation: Limitations include a cross-sectional study design that precludes establishing causality. Analyses did not control for medication use. Younger participant age may prevent evaluation of associations with late-life illnesses.
   Conclusions: Evening chronotype may be a discrete clinical subphenotype in BD and circadian dysfunction a shared pathophysiological mechanism between psychopathology and medical morbidity.
C1 [Romo-Nava, Francisco; Blom, Thomas J.; McElroy, Susan L.] Lindner Ctr HOPE, Mason, OH USA.
   [Romo-Nava, Francisco; Blom, Thomas J.; McElroy, Susan L.] Univ Cincinnati, Coll Med, Dept Psychiat & Behav Neurosci, Cincinnati, OH USA.
   [Cuellar-Barboza, Alfredo B.] Univ Autonoma Nuevo Leon, Dept Psychiat, Monterrey, Mexico.
   [Nunez, Nicolas A.; Biernacka, Joanna M.; Frye, Mark A.] Mayo Clin, Dept Psychiat & Psychol, Rochester, MN USA.
   [Winham, Stacey J.; Colby, Colin L.; Biernacka, Joanna M.] Mayo Clin, Dept Hlth Sci Res, Rochester, MN USA.
C3 University System of Ohio; University of Cincinnati; Universidad
   Autonoma de Nuevo Leon; Mayo Clinic; Mayo Clinic
RP Romo-Nava, F (corresponding author), Univ Cincinnati, Dept Psychiat & Behav Neurosci, Coll Med, Lindner Ctr HOPE,Res Inst, 4075 Old Western Row Rd Suite A164, Mason, OH 45040 USA.
EM romofo@ucmail.uc.edu
RI Nunez, Nicolas/HPD-4606-2023; Cuellar-Barboza, Alfredo/A-9278-2015
OI Cuellar-Barboza, Alfredo/0000-0002-7663-913X; Romo-Nava,
   Francisco/0000-0002-5894-3701
FU Marriott Foundation
FX This study was supported by the Marriott Foundation. The Marriott
   Foundation had no role in the design and conduct of the study;
   collection, management, analysis, and interpretation of the data;
   preparation, review, or approval of the manuscript; and decision to
   submit the manuscript for publication.
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NR 80
TC 40
Z9 41
U1 0
U2 14
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD APR 1
PY 2020
VL 266
BP 556
EP 562
DI 10.1016/j.jad.2020.01.151
PG 7
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA KW0WA
UT WOS:000520892700072
PM 32056926
DA 2025-06-11
ER

PT J
AU Narita, K
   Murata, T
   Takahashi, T
   Hamada, T
   Kosaka, H
   Yoshida, H
   Wada, Y
AF Narita, Kosuke
   Murata, Tetsuhito
   Takahashi, Tetsuya
   Hamada, Toshihiko
   Kosaka, Hirotaka
   Yoshida, Haruyoshi
   Wada, Yuji
TI The association between anger-related personality trait and cardiac
   autonomic response abnormalities in elderly subjects
SO EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
LA English
DT Article
DE anger personality trait; heart rate variability; autonomic response;
   postmenopausal female subjects; intima-medial thickness
ID HEART-RATE-VARIABILITY; POWER SPECTRAL-ANALYSIS; BLOOD-PRESSURE;
   METABOLIC SYNDROME; ATHEROSCLEROSIS; EXPRESSION; HOSTILITY; SYMPTOMS;
   ANXIETY; MARKER
AB Cardiac autonomic response abnormality associated with trait anger has been recognized to elevate blood pressure in daily life, leading to atherosclerotic progression and cardiovascular disease. To clarify the relationship between anger-related personality traits and cardiac autonomic response in healthy elderly subjects, 54 volunteers consisting of 30 male (mean age 62.2 +/- 5.4) and 24 female (mean age 58.4 +/- 4.6) subjects underwent testing of heart rate variability (HRV) with head-up tilt. For the evaluation of trait anger, we used a questionnaire corresponding to the trait anger score taken from the State and Trait Anger Expression Inventory. Furthermore, we measured carotid intima-medial thickness (IMT) to evaluate atherosclerotic progression in subjects with anger trait. In female subjects, higher trait anger was positively associated with elevated carotid IMT and the suppression of HRV vagal attenuation from the supine to head-up position, and negatively associated with the HRV sympathetic activity in the head-up position and also with the HRV sympathetic response from the supine to head-up position. In male subjects, trait anger was not significantly associated with carotid IMT or any HRV component with or without head-up tilt testing. We conclude that a simple noninvasive measure, short-term HRV with head-up tilt testing, could be a useful method to investigate the association between cardiac autonomic imbalance and increased risk of atherosclerosis associated with trait anger in healthy elderly subjects.
C1 Univ Fukui, Dept Neuropsychiat, Fukui 910, Japan.
   Univ Fukui, Dept Clin & Lab Sci, Fukui 910, Japan.
C3 University of Fukui; University of Fukui
RP Murata, T (corresponding author), Univ Fukui, Dept Neuropsychiat, Fukui 910, Japan.
EM tmurata@fmsrsa.fukui-med.ac.jp
RI Kosaka, Hirotaka/AFG-5500-2022; Yoshida, Haruyoshi/IRZ-6376-2023;
   Takahashi, Tetsuya/ABG-8566-2021
OI Kosaka, Hirotaka/0000-0003-2210-5025
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NR 27
TC 6
Z9 8
U1 0
U2 5
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0940-1334
EI 1433-8491
J9 EUR ARCH PSY CLIN N
JI Eur. Arch. Psych. Clin. Neurosci.
PD SEP
PY 2007
VL 257
IS 6
BP 325
EP 329
DI 10.1007/s00406-007-0724-4
PG 5
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA 213DW
UT WOS:000249647300003
PM 17401729
DA 2025-06-11
ER

PT J
AU Kristóf, Z
   Baranyi, M
   Tod, P
   Mut-Arbona, P
   Demeter, K
   Bitter, I
   Sperlágh, B
AF Kristof, Zsuliet
   Baranyi, Maria
   Tod, Pal
   Mut-Arbona, Paula
   Demeter, Kornel
   Bitter, Istvan
   Sperlagh, Beata
TI Elevated Serum Purine Levels in Schizophrenia: A Reverse Translational
   Study to Identify Novel Inflammatory Biomarkers
SO INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
LA English
DT Article
DE Biomarkers; neuroinflammation; purinergic signaling; schizophrenia
ID P2X7 RECEPTOR; METABOLIC SYNDROME; POTENTIAL ROLE; EMERGING ROLE; MOUSE
   MODEL; SYMPTOMS; METAANALYSIS; PSYCHOSIS; CYTOKINES; SYSTEM
AB Background Immunological markers and related signaling molecules in the blood are altered in schizophrenia mouse models, in acutely relapsed patients with schizophrenia, and in persons at a clinically high risk for subsequently developing psychosis, highlighting their potential as prognostic and theranostic biomarkers. Therefore, we herein aimed to identify novel potential biomarkers in the serum that are associated with purinergic signaling. Methods To our knowledge, this is the first study to assess the correlations among the levels of human serum adenine nucleotides (ATP, ADP), adenosine, P2X7 receptor, and disease activity in patients hospitalized due to an acute relapse of schizophrenia (n = 53) and healthy controls (n = 47). In addition, to validate these findings using a reverse translational approach, we examined the same parameters in an acute phencyclidine-induced schizophrenia mouse model. Results We found consistently elevated levels of ATP, ADP, interleukin (IL)-6, and IL-10 in both schizophrenia groups compared with the controls. The levels of adenosine, IL-1 beta, IL-12, and C-reactive protein were also increased in the human patient samples. Moreover, ATP and ADP were significantly positively correlated with the Positive and Negative Symptom Scale item "lack of judgment and insight"; IL-1 beta, IL-12, and tumour necrosis factor alpha were significantly positively correlated with "tension" and "depression"; and "disorientation" and "poor attention" were correlated significantly with IL-6 and IL-8. Conclusions Our study suggests the promising potential of blood purines and inflammatory markers as future prognostic tools.
C1 [Kristof, Zsuliet; Baranyi, Maria; Tod, Pal; Mut-Arbona, Paula; Sperlagh, Beata] Inst Expt Med, Lab Mol Pharmacol, Budapest, Hungary.
   [Kristof, Zsuliet; Bitter, Istvan] Semmelweis Univ, Doctoral Sch Mental Hlth Sci, Budapest, Hungary.
   [Mut-Arbona, Paula; Sperlagh, Beata] Semmelweis Univ, Janos Szentagothai Neurosci Doctoral Sch, Budapest, Hungary.
   [Demeter, Kornel] Inst Expt Med, Behav Unit, Budapest, Hungary.
   [Bitter, Istvan] Semmelweis Univ, Dept Psychiat & Psychotherapy, Budapest, Hungary.
C3 HUN-REN; HUN-REN Institute of Experimental Medicine; Semmelweis
   University; Semmelweis University; HUN-REN; HUN-REN Institute of
   Experimental Medicine; Semmelweis University
RP Sperlágh, B (corresponding author), Szigony 43, H-1083 Budapest, Hungary.
RI Demeter, Kornel/GRF-0289-2022; Mut-Arbona, Paula/AAE-2331-2020; Tod,
   Pál/H-9607-2018; Kristof, Zsuliet/P-2755-2019; Bitter,
   Istvan/J-8196-2017
OI Mut-Arbona, Paula/0000-0002-3804-3140
FU Hungarian Research and Development Fund [131629]; Hungarian Brain
   Research Program [2017-1.2.1-NKP-2017-00002]; European Union [766124]
FX This work was supported by the Hungarian Research and Development Fund
   (grant no. 131629), the Hungarian Brain Research Program
   (2017-1.2.1-NKP-2017-00002 awarded to B.S. [laboratory studies] and to
   I.B. [clinical study]), and the European Union's Horizon 2020 Research
   and Innovation Program Marie Skodowska Curie grant (no. 766124).
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NR 86
TC 8
Z9 8
U1 1
U2 3
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1461-1457
EI 1469-5111
J9 INT J NEUROPSYCHOPH
JI Int. J. Neuropsychopharmacol.
PD AUG 16
PY 2022
VL 25
IS 8
BP 645
EP 659
DI 10.1093/ijnp/pyac026
EA MAY 2022
PG 15
WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA 3U3JP
UT WOS:000791763300001
PM 35443035
OA Green Published, gold, Green Accepted
DA 2025-06-11
ER

PT J
AU Tian, Z
   Zhang, YC
   Wang, Y
   Chang, XH
   Zhu, HL
   Zhao, Y
AF Tian, Zhao
   Zhang, Yi-Chao
   Wang, Yue
   Chang, Xiao-Hong
   Zhu, Hong-Lan
   Zhao, Yan
TI Effects of bariatric surgery on patients with obesity and polycystic
   ovary syndrome: a meta-analysis
SO SURGERY FOR OBESITY AND RELATED DISEASES
LA English
DT Article
DE Bariatric surgery; Polycystic ovary syndrome; Hormonal; Metabolism
ID GASTRIC BYPASS-SURGERY; METABOLIC SYNDROME; WOMEN; HORMONES; BIOMARKERS;
   STATEMENT; OUTCOMES; INSULIN
AB Background: Bariatric surgery is effective for polycystic ovary syndrome (PCOS), while the exact mechanism remains unclear.
   Objectives: To assess the impact of bariatric surgery on PCOS patients and further explore the possible mechanism.
   Setting: A meta-analysis.
   Methods: We searched PubMed, Web of Science, The Cochrane Library, and Embase to identify relevant studies published before November 2020.
   Results: Twenty-one studies met our inclusion criteria, and we identified 552 patients with PCOS study. Results showed that the prevalence of preoperative PCOS, menstrual irregularity, hirsutism, type 2 diabetes (T2D), hypertension, infertility, and depression significantly decreased after bariatric surgery. Levels of total testosterone, fasting insulin, and luteinizing hormone (LH) decreased and estradiol increased, while levels of follicle-stimulating hormone (FSH) and LH/FSH did not show sig-nificant changes during the 3-month follow-up. There were decreases in testosterone and fasting insulin levels when the postoperative follow-up time was 6 months or >12 months. Levels of fasting blood glucose and triglycerides were significantly reduced after 6 months or >12 months of bariatric surgery. High-density lipoprotein (HDL) and sex hormone-binding globulin (SHBG) significantly improved >12 months after bariatric surgery.
   Conclusion: Symptoms of PCOS and related complications are significantly alleviated after bariat-ric surgery. In addition, we found a significant improvement on anomalous secretion of gonadotro-pins, glucose metabolism, and lipid metabolism in patients with PCOS after bariatric surgery. (C) 2021 American Society for Bariatric Surgery. Published by Elsevier Inc. All rights reserved.
C1 [Tian, Zhao; Wang, Yue; Chang, Xiao-Hong; Zhu, Hong-Lan; Zhao, Yan] Peking Univ, Peoples Hosp, Dept Obstet & Gynecol, Beijing 100044, Peoples R China.
   [Zhang, Yi-Chao] Xian Med Univ, Xijing Hosp, Dept Digest Surg, Xian, Peoples R China.
C3 Peking University; Xi'an Medical University; Air Force Medical
   University
RP Zhu, HL (corresponding author), Peking Univ, Peoples Hosp, Dept Obstet & Gynecol, Beijing 100044, Peoples R China.
EM honglanzhu01@163.com
RI Wang, Yue/E-9002-2010; Tian, Zhao/JQW-5349-2023
OI Tian, Zhao/0000-0001-9649-9405
FU Peking University Medicine Seed Fund for Interdisciplinary Research -
   Fundamental Research Funds for the Central Universities [BMU2020MX003]
FX This work was supported by the Peking University Medicine Seed Fund for
   Interdisciplinary Research, which was supported by Fundamental Research
   Funds for the Central Universities (No. BMU2020MX003).
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NR 57
TC 19
Z9 19
U1 1
U2 8
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1550-7289
EI 1878-7533
J9 SURG OBES RELAT DIS
JI Surg. Obes. Relat. Dis.
PD AUG
PY 2021
VL 17
IS 8
BP 1399
EP 1408
DI 10.1016/j.soard.2021.04.009
EA JUL 2021
PG 10
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA TP2QB
UT WOS:000677439200003
PM 34006495
DA 2025-06-11
ER

PT J
AU Delacrétaz, A
   Glatard, A
   Dubath, C
   Gholam-Rezaee, M
   Sanchez-Mut, JV
   Gräff, J
   von Gunten, A
   Conus, P
   Eap, CB
AF Delacretaz, Aurelie
   Glatard, Anais
   Dubath, Celine
   Gholam-Rezaee, Mehdi
   Sanchez-Mut, Jose Vicente
   Graff, Johannes
   von Gunten, Armin
   Conus, Philippe
   Eap, Chin B.
TI Psychotropic drug-induced genetic-epigenetic modulation of CRTC1
   gene is associated with early weight gain in a prospective study of
   psychiatric patients
SO CLINICAL EPIGENETICS
LA English
DT Article
DE Early weight gain; Psychotropic drugs; CRTC1; Methylation; Psychiatric
   population
ID BODY-MASS INDEX; DNA METHYLATION; INSULIN-RESISTANCE; METABOLIC
   SYNDROME; MOOD STABILIZERS; BIPOLAR DISORDER; EPIGENOME-WIDE;
   SCHIZOPHRENIA; ANTIPSYCHOTICS; DEPRESSION
AB Background: Metabolic side effects induced by psychotropic drugs represent a major health issue in psychiatry. CREB-regulated transcription coactivator 1 (CRTC1) gene plays a major role in the regulation of energy homeostasis and epigenetic mechanisms may explain its association with obesity features previously described in psychiatric patients. This prospective study included 78 patients receiving psychotropic drugs that induce metabolic disturbances, with weight and other metabolic parameters monitored regularly. Methylation levels in 76 CRTC1 probes were assessed before and after 1 month of psychotropic treatment in blood samples.
   Results: Significant methylation changes were observed in three CRTC1 CpG sites (i.e., cg07015183, cg12034943, and cg 17006757) in patients with early and important weight gain (i.e., equal or higher than 5% after 1 month; FDR p value = 0.02). Multivariable models showed that methylation decrease in cg12034943 was more important in patients with early weight gain (>= 5%) than in those who did not gain weight (p = 0.01). Further analyses combining genetic and methylation data showed that cg12034943 was significantly associated with early weight gain in patients carrying the G allele of rs4808844A>G (p = 0.03), a SNP associated with this methylation site (p = 0.03).
   Conclusions: These findings give new insights on psychotropic-induced weight gain and underline the need of future larger prospective epigenetic studies to better understand the complex pathways involved in psychotropic-induced metabolic side effects.
C1 [Delacretaz, Aurelie; Glatard, Anais; Dubath, Celine; Eap, Chin B.] Univ Lausanne, Univ Lausanne Hosp, Unit Pharmacogenet & Clin Psychopharmacol, Ctr Psychiat Neurosci,Dept Psychiat, Prilly, Switzerland.
   [Gholam-Rezaee, Mehdi] Univ Lausanne, Univ Lausanne Hosp, Dept Psychiat, Ctr Psychiat Epidemiol & Psychopathol, Prilly, Switzerland.
   [Sanchez-Mut, Jose Vicente; Graff, Johannes] Ecole Polytech Fed Lausanne, Sch Life Sci, Brain Mind Inst, Lab Neuroepigenet, Lausanne, Switzerland.
   [von Gunten, Armin] Univ Lausanne, Univ Lausanne Hosp, Dept Psychiat, Serv Old Age Psychiat, Prilly, Switzerland.
   [Conus, Philippe] Univ Lausanne, Univ Lausanne Hosp, Dept Psychiat, Serv Gen Psychiat, Prilly, Switzerland.
   [Eap, Chin B.] Univ Geneva, Inst Pharmaceut Sci Western Switzerland, Geneva, Switzerland.
C3 University of Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV);
   University of Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV);
   Swiss School of Public Health (SSPH+); Swiss Federal Institutes of
   Technology Domain; Ecole Polytechnique Federale de Lausanne; University
   of Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV); University
   of Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV); University
   of Geneva
RP Eap, CB (corresponding author), Univ Lausanne, Univ Lausanne Hosp, Unit Pharmacogenet & Clin Psychopharmacol, Ctr Psychiat Neurosci,Dept Psychiat, Prilly, Switzerland.; Eap, CB (corresponding author), Univ Geneva, Inst Pharmaceut Sci Western Switzerland, Geneva, Switzerland.
EM chin.eap@chuv.ch
RI Sanchez-Mut, Jose/A-8651-2019
OI von Gunten, Armin/0000-0001-7852-3803; Graff,
   Johannes/0000-0002-3219-3578; Conus, Philippe/0000-0002-5832-1910
FU Swiss National Research Foundation [320030-120686, 324730-144064,
   320030-173211]; Swiss National Science Foundation (SNF) [320030_173211,
   320030-120686] Funding Source: Swiss National Science Foundation (SNF)
FX This work has been funded in part by the Swiss National Research
   Foundation (CBE and PC: 320030-120686, 324730-144064, and
   320030-173211). The funding sources had no role in the writing of the
   manuscript or in the decision to submit it for publication.
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NR 72
TC 6
Z9 6
U1 0
U2 6
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1868-7075
EI 1868-7083
J9 CLIN EPIGENETICS
JI Clin. Epigenetics
PD DEC 26
PY 2019
VL 11
IS 1
AR 198
DI 10.1186/s13148-019-0792-0
PG 11
WC Oncology; Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Genetics & Heredity
GA KH4UW
UT WOS:000510645500001
PM 31878957
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Krosniak, M
   Francik, R
   Wojtanowska-Krosniak, A
   Tedeschi, C
   Krason-Nowak, M
   Chlopicka, J
   Grybos, R
AF Krosniak, Miroslaw
   Francik, Renata
   Wojtanowska-Krosniak, Agnieszka
   Tedeschi, Cinzia
   Krason-Nowak, Malgorzata
   Chlopicka, Joanna
   Grybos, Ryszard
TI Vanadium Methyl-Bipyridine Organoligand and its Influence on Energy
   Balance and Organs Mass
SO BIOLOGICAL TRACE ELEMENT RESEARCH
LA English
DT Article
DE Vanadium; High-fructose diet; High-fat diet; Rat; Body mass growth
ID HIGH-FAT; PHYSICAL-ACTIVITY; FRUCTOSE; RATS; DIET; OBESITY; TRIAL;
   COMBINATION; DEPRESSION; COMPLEX
AB In the treatment of lifestyle diseases, including metabolic syndrome and type 2 diabetes, it is important to lower body mass and fat tissue, and consequently, to increase insulin-sensitivity. Unfortunately, it often happens that low-energy diet which would lower overweight is not observed and, thus, it does not bring the expected effects. This paper discusses the influence of three diets-control, high-fructose, and high-fatty diet-on absorption of energy from food in order to transform it into body mass. The kJ/g ratio which describes this process has been calculated. In the tested diets, the addition of fructose (79.13 +/- 2.47 kJ/g) or fat (82.48 +/- 2.28 kJ/g) results in higher transformation of energy into body mass than in the case of control diet (89.60 +/- 1.86 kJ/g). The addition of Na[VO(O-2)(2)(4,4'-Me-2-2,2'-bpy)]aEuro cent 8H(2)O (where 4,4'-Me-2-2,2'-bpy = 4,4'-dimethyl-2,2'-bipyridine) results in statistical increase of that ratio: fructose diet (86.88 +/- 0.44 kJ/g), fat diet (104.68 +/- 3.01 kJ/g), and control diet (115.98 +/- 0.56 kJ/g), respectively. Fat diet statistically influences the decrease of kidney mass in comparison to the other diets. The application of the tested vanadium compound results also in the statistical decrease of the fatty liver caused by fructose and fat diet.
C1 [Krosniak, Miroslaw; Wojtanowska-Krosniak, Agnieszka; Chlopicka, Joanna] Jagiellonian Univ, Dept Food Chem & Nutr, Coll Med, PL-30688 Krakow, Poland.
   [Francik, Renata; Krason-Nowak, Malgorzata] Jagiellonian Univ, Dept Bioorgan Chem, Coll Med, PL-30688 Krakow, Poland.
   [Francik, Renata] State Higher Vocat Sch, Inst Hlth, PL-33300 Nowy Sacz, Poland.
   [Tedeschi, Cinzia] Univ Calabria, Dept Food Chem & Nutr, Fac Pharm Nutr & Hlth Sci, Arcavacata Di Rende, Italy.
   [Tedeschi, Cinzia] Jagiellonian Univ, Erasmus Program, Coll Med, Krakow, Poland.
   [Grybos, Ryszard] Jagiellonian Univ, Fac Chem, PL-30060 Krakow, Poland.
C3 Jagiellonian University; Collegium Medicum Jagiellonian University;
   Jagiellonian University; Collegium Medicum Jagiellonian University;
   University of Calabria; Jagiellonian University; Collegium Medicum
   Jagiellonian University; Jagiellonian University
RP Krosniak, M (corresponding author), Jagiellonian Univ, Dept Food Chem & Nutr, Coll Med, 9 Med Str, PL-30688 Krakow, Poland.
EM mfkrosni@cyf-kr.edu.pl
RI Francik, Renata/AAB-4791-2020; Krosniak, Miroslaw/U-8884-2018
OI Francik, Renata/0000-0002-7071-8072; Grybos,
   Ryszard/0000-0001-7340-328X; Krosniak, Miroslaw/0000-0002-5417-2428
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NR 47
TC 1
Z9 2
U1 0
U2 9
PU HUMANA PRESS INC
PI TOTOWA
PA 999 RIVERVIEW DRIVE SUITE 208, TOTOWA, NJ 07512 USA
SN 0163-4984
EI 1559-0720
J9 BIOL TRACE ELEM RES
JI Biol. Trace Elem. Res.
PD SEP
PY 2014
VL 160
IS 3
BP 376
EP 382
DI 10.1007/s12011-014-0064-y
PG 7
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA AN3PR
UT WOS:000340500900009
PM 25015881
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Li, YK
   Liu, XY
   Lv, WH
   Wang, XS
   Du, ZH
   Liu, XM
   Meng, FC
   Jin, SQ
   Wen, SN
   Bai, R
   Liu, N
   Tang, RB
AF Li, Yukun
   Liu, Xiaoying
   Lv, Wenhe
   Wang, Xuesi
   Du, Zhuohang
   Liu, Xinmeng
   Meng, Fanchao
   Jin, Shuqi
   Wen, Songnan
   Bai, Rong
   Liu, Nian
   Tang, Ribo
TI Metformin use correlated with lower risk of cardiometabolic diseases and
   related mortality among US cancer survivors: evidence from a nationally
   representative cohort study
SO BMC MEDICINE
LA English
DT Article
DE Cardiometabolic disease; Cancer; Cardio-oncology; Metformin; Oxidative
   stress
ID OXIDATIVE STRESS; PREDICTION
AB BackgroundIn the USA, the prolonged effective survival of cancer population has brought significant attention to the rising risk of cardiometabolic morbidity and mortality in this population. This heightened risk underscores the urgent need for research into effective pharmacological interventions for cancer survivors. Notably, metformin, a well-known metabolic regulator with pleiotropic effects, has shown protective effects against cardiometabolic disorders in diabetic individuals. Despite these promising indications, evidence supporting its efficacy in improving cardiometabolic outcomes in cancer survivors remains scarce.MethodsA prospective cohort was established using a nationally representative sample of cancer survivors enrolled in the US National Health and Nutrition Examination Survey (NHANES), spanning 2003 to 2018. Outcomes were derived from patient interviews, physical examinations, and public-access linked mortality archives up to 2019. The Oxidative Balance Score was utilized to assess participants' levels of oxidative stress. To evaluate the correlations between metformin use and the risk of cardiometabolic diseases and related mortality, survival analysis of cardiometabolic mortality was performed by Cox proportional hazards model, and cross-sectional analysis of cardiometabolic diseases outcomes was performed using logistic regression models. Interaction analyses were conducted to explore the specific pharmacological mechanism of metformin.ResultsAmong 3995 cancer survivors (weighted population, 21,671,061, weighted mean [SE] age, 62.62 [0.33] years; 2119 [53.04%] females; 2727 [68.26%] Non-Hispanic White individuals), 448 reported metformin usage. During the follow-up period of up to 17 years (median, 6.42 years), there were 1233 recorded deaths, including 481 deaths from cardiometabolic causes. Multivariable models indicated that metformin use was associated with a lower risk of all-cause (hazard ratio [HR], 0.62; 95% confidence interval [CI], 0.47-0.81) and cardiometabolic (HR, 0.65; 95% CI, 0.44-0.97) mortality compared with metformin nonusers. Metformin use was also correlated with a lower risk of total cardiovascular disease (odds ratio [OR], 0.41; 95% CI, 0.28-0.59), stroke (OR, 0.44; 95% CI, 0.26-0.74), hypertension (OR, 0.27; 95% CI, 0.14-0.52), and coronary heart disease (OR, 0.41; 95% CI, 0.21-0.78). The observed inverse associations were consistent across subgroup analyses in four specific cancer populations identified as cardiometabolic high-risk groups. Interaction analyses suggested that metformin use as compared to non-use may counter-balance oxidative stress.ConclusionsIn this cohort study involving a nationally representative population of US cancer survivors, metformin use was significantly correlated with a lower risk of cardiometabolic diseases, all-cause mortality, and cardiometabolic mortality.
   Question:Is metformin use associated with diminished risk of cardiometabolic diseases and related mortality in cancer survivors? If so, what mechanisms contribute to this inverse association with cardiometabolic risk?Findings:In this cohort study of 3995 cancer survivors over a median period of 6.42 years, metformin use was correlated with decreased risks of cardiometabolic diseases, all-cause and cardiometabolic mortality, likely due to its oxidative stress antagonism.Meaning:These study findings indicated that metformin use was associated with improved cardiometabolic health, leading to enhanced overall survival and quality of life in cancer survivors. Moreover, targeting oxidative stress may be crucial in developing cardiometabolic protective drugs for patients with cancer in the future.
C1 [Li, Yukun; Liu, Xiaoying; Lv, Wenhe; Wang, Xuesi; Du, Zhuohang; Liu, Xinmeng; Meng, Fanchao; Jin, Shuqi; Liu, Nian; Tang, Ribo] Capital Med Univ, Beijing Anzhen Hosp, Dept Cardiol, Beijing 100012, Peoples R China.
   [Li, Yukun; Liu, Xiaoying; Lv, Wenhe; Wang, Xuesi; Du, Zhuohang; Liu, Xinmeng; Meng, Fanchao; Jin, Shuqi; Liu, Nian; Tang, Ribo] Natl Clin Res Ctr Cardiovasc Dis, Beijing 100012, Peoples R China.
   [Bai, Rong] Univ Arizona, Coll Med, Banner Univ Med Ctr Phoenix, Phoenix, AZ 85123 USA.
   [Wen, Songnan] Mayo Clin, Dept Cardiovasc Med, Scottsdale, AZ 85259 USA.
C3 Capital Medical University; University of Arizona; Mayo Clinic; Mayo
   Clinic Phoenix
RP Liu, N; Tang, RB (corresponding author), Capital Med Univ, Beijing Anzhen Hosp, Dept Cardiol, Beijing 100012, Peoples R China.; Liu, N; Tang, RB (corresponding author), Natl Clin Res Ctr Cardiovasc Dis, Beijing 100012, Peoples R China.; Bai, R (corresponding author), Univ Arizona, Coll Med, Banner Univ Med Ctr Phoenix, Phoenix, AZ 85123 USA.
EM bairong74@gmail.com; liunian1973@hotmail.com; tangribo@163.com
RI Wang, Xuesi/ABC-2372-2021; Meng, Charles/IST-8594-2023; Li,
   yukun/HZJ-2455-2023
OI Li, Yukun/0000-0003-0516-5480
FU National Natural Science Foundation of China [81870243, 82170318,
   82170310]
FX This work was supported by the National Natural Science Foundation of
   China [grant numbers 81870243, 82170318, 82170310].
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NR 47
TC 7
Z9 7
U1 2
U2 3
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1741-7015
J9 BMC MED
JI BMC Med.
PD JUN 26
PY 2024
VL 22
IS 1
AR 269
DI 10.1186/s12916-024-03484-y
PG 16
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA WN2M9
UT WOS:001255488800003
PM 38926749
OA gold
DA 2025-06-11
ER

PT J
AU Sinha, S
   Haque, M
AF Sinha, Susmita
   Haque, Mainul
TI Insulin Resistance and Type 2 Diabetes Mellitus: An Ultimatum to Renal
   Physiology
SO CUREUS JOURNAL OF MEDICAL SCIENCE
LA English
DT Review
DE end-stage renal disease (esrd); chronic kidney disease; diabetes
   mellitus; podocytes; renal tubular cells; pi3k pathway; vasodilation;
   nitric oxide; insulin resistance; insulin
ID CHRONIC KIDNEY-DISEASE; ENDOTHELIAL FUNCTION; OXIDATIVE STRESS;
   RECEPTOR; HYPERGLYCEMIA; INHIBITION; INJURY; PATHOPHYSIOLOGY;
   INFLAMMATION; PHOSPHATASES
AB Insulin resistance (IR) is stated as diminished insulin action regardless of hyperinsulinemia. The usual target organs for insulin activities are the liver, skeletal muscle, and adipose tissue. Hence, the vasculature and kidneys are nonconventional target organs as the impacts of insulin on these are comparatively separate from other conventional target organs. Vasodilation is achieved by raising endothelial nitric oxide (NO) generation by initiating the phosphoinositide 3-kinase (PI3K) pathway. In insulin-nonresponsive conditions, this process is defective, and there is increased production of endothelin-1 through the mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) pathway, which predominates the NO effects, causing vasoconstriction. Renal tubular cells and podocytes have insulin receptors, and their purposeful importance has been studied, which discloses critical acts of insulin signaling in podocyte survivability and tubular action. Diabetic nephropathy (DN) is a prevalent problem in individuals with hypertension, poor glycemic management, hereditary susceptibility, or glomerular hyperfiltration. DN could be a significant contributing factor to end-stage renal disease (ESRD) that results from chronic kidney disease (CKD). IR and diabetes mellitus (DM) are the constituents of syndrome X and are accompanied by CKD progression. IR performs a key part in syndrome X leading to CKD. However, it is indistinct whether IR individually participates in enhancing the threat to CKD advancement rather than CKD complexity. CKD is an extensive public health problem affecting millions of individuals worldwide. The tremendous spread of kidney disease intensifies people's health impacts related to communicable and noncommunicable diseases. Chronic disease regulator policies do not include CKD at global, local, and/or general levels. Improved knowledge of the character of CKD-associated problems might aid in reforming diagnosis, prevention, and management.
C1 [Sinha, Susmita] Khulna City Med Coll Hosp, Physiol, Khulna, Bangladesh.
   [Haque, Mainul] Natl Def Univ Malaysia, Pharmacol & Therapeut, Kuala Lumpur, Malaysia.
C3 Universiti Pertahanan Nasional Malaysia
RP Haque, M (corresponding author), Natl Def Univ Malaysia, Pharmacol & Therapeut, Kuala Lumpur, Malaysia.
EM runurono@gmail.com
RI Sinha, Susmita/HGC-1750-2022; Haque, Mainul/ABG-2866-2020
OI Sinha, Susmita/0000-0002-3591-1109
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NR 69
TC 10
Z9 10
U1 1
U2 5
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
EI 2168-8184
J9 CUREUS J MED SCIENCE
JI Cureus J Med Sci
PD SEP 8
PY 2022
VL 14
IS 9
DI 10.7759/cureus.28944
PG 11
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA 4X1QK
UT WOS:000860624300030
PM 36111327
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Chung, S
   Park, CW
   Shin, SJ
   Lim, JH
   Chung, HW
   Youn, DY
   Kim, HW
   Kim, BS
   Lee, JH
   Kim, GH
   Chang, YS
AF Chung, Sungjin
   Park, Cheol Whee
   Shin, Seok Joon
   Lim, Ji Hee
   Chung, Hyun Wha
   Youn, Dong-Ye
   Kim, Hyung Wook
   Kim, Byung Soo
   Lee, Jeong-Hwa
   Kim, Gheun-Ho
   Chang, Yoon Sik
TI Tempol or candesartan prevents high-fat diet-induced hypertension and
   renal damage in spontaneously hypertensive rats
SO NEPHROLOGY DIALYSIS TRANSPLANTATION
LA English
DT Article
DE hypertension; lipotoxicity; obesity; oxidative stress; renin-angiotensin
   system
ID RENIN-ANGIOTENSIN SYSTEM; INSULIN-RESISTANCE; BLOOD-PRESSURE;
   DIABETIC-NEPHROPATHY; OXIDATIVE STRESS; METABOLIC SYNDROME;
   NITRIC-OXIDE; OBESITY; ALDOSTERONE; KIDNEY
AB Methods. Male SHR and Wistar-Kyoto rats (WKY) were divided into eight groups: normal-fat diet-fed WKY (WKY-NF), high-fat diet-fed WKY (WKY-HF), high-fat diet-fed tempol-treated WKY (WKY-HF/T), high-fat diet-fed candesartan-treated WKY (WKY-HF/C), normal-fat diet-fed SHR (SHR-NF), high-fat diet-fed SHR (SHR-HF), high-fat diet-fed tempol-treated SHR (SHR-HF/T) and high-fat diet-fed candesartan-treated SHR (SHR-HF/C). After 12 weeks of treatment, haemodynamic measurements and histological assessment of the kidney were performed.
   Results. At the end of week 12, the high-fat fed SHR gained more body weight, their systolic blood pressure was further elevated and glucose intolerance induced. There was no significant difference in the insulin resistance index, serum lipid profile, plasma renin activity and serum aldosterone levels according to diet. However, the high-fat diet resulted in increases in immunohistochemical stains of renin and angiotensin II in the kidney. The real-time PCR also demonstrated significant increases in mRNA levels of renin, angiotensinogen and angiotensin-converting enzyme in the kidney, reflecting enhanced activation of the intrarenal RAS, which findings were also shown by Western blot analysis for renin and angiotensin II type 1 receptor. The expression of ED-1, osteopontin and TGF-beta 1 in the renal cortex were prominently enhanced in the SHR-HF group with the increased intrarenal lipid concentrations and oxidative stress. Administration of tempol or candesartan in the high-fat diet-induced SHR inhibited the elevation of the systolic blood pressure, intrarenal lipid concentrations, oxidative stress and the degree of renal inflammation to the levels of, or more than, the SHR-NF with no differences in the body weight and periepididymal fat weight, compared to those in the SHR-HF group without such treatment.
   Conclusions. Our study suggests that a high-fat diet induces fatty kidneys, aggravation of blood pressure and renal inflammation in the SHR. Blockade of oxidative stress by tempol or of RAS by candesartan ameliorates the increase in blood pressure and renal inflammation and improves intrarenal lipid accumulation. Therefore, antioxidants or angiotensin receptor blockers can prevent diet-induced hypertension and renal inflammation in hypertensive rats.
C1 [Chung, Sungjin; Park, Cheol Whee; Shin, Seok Joon; Lim, Ji Hee; Chung, Hyun Wha; Kim, Hyung Wook; Kim, Byung Soo; Chang, Yoon Sik] Catholic Univ Korea, Coll Med, Dept Internal Med, Div Nephrol, Seoul, South Korea.
   [Youn, Dong-Ye; Lee, Jeong-Hwa] Catholic Univ Korea, Coll Med, Dept Biochem, Seoul, South Korea.
   [Kim, Gheun-Ho] Hanyang Univ, Coll Med, Dept Internal Med, Div Nephrol, Seoul 133791, South Korea.
C3 Catholic University of Korea; Catholic University of Korea; Hanyang
   University
RP Chang, YS (corresponding author), Catholic Univ Korea, Coll Med, Dept Internal Med, Div Nephrol, Seoul, South Korea.
EM ysc543@unitel.co.kr
RI Chung, Sungjin/AAJ-8836-2020; Lee, Jeong/JFA-4725-2023; Kim,
   Byung-Soo/H-4047-2013; Kim, Hyung-Wook/B-6308-2009; Kim, Yon/J-2743-2012
OI Kim, Gheun-Ho/0000-0002-8445-9892; Chung, Sungjin/0000-0002-9886-8339
FU Catholic Medical Center Research Foundation; Korean MSD
   [5-2008-D0220-00002]; Korea government (MEST) [R01-2009-0073171]
FX The authors wish to acknowledge the financial support of the Catholic
   Medical Center Research Foundation and the Korean MSD for this work
   (5-2008-D0220-00002). This work was also supported by the Korea Science
   and Engineering Foundation (KOSEF) grant funded by the Korea government
   (MEST) (R01-2009-0073171).
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NR 53
TC 47
Z9 53
U1 0
U2 12
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0931-0509
EI 1460-2385
J9 NEPHROL DIAL TRANSPL
JI Nephrol. Dial. Transplant.
PD FEB
PY 2010
VL 25
IS 2
BP 389
EP 399
DI 10.1093/ndt/gfp472
PG 11
WC Transplantation; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Transplantation; Urology & Nephrology
GA 547LY
UT WOS:000273891600014
PM 19749146
OA Bronze
DA 2025-06-11
ER

PT J
AU Leduc, L
   Levy, E
   Bouity-Voubou, M
   Delvin, E
AF Leduc, Line
   Levy, Emile
   Bouity-Voubou, Maurice
   Delvin, Edgard
TI Fetal programming of atherosclerosis: Possible role of the mitochondria
SO EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
LA English
DT Review
DE Fetal programming of atherosclerosis; Oxidative stress; Inflammation;
   Mitochondria; Mitochondrial dysfunction
ID INTRAUTERINE GROWTH RESTRICTION; LOW-BIRTH-WEIGHT; INTIMA-MEDIA
   THICKNESS; ENDOTHELIUM-DEPENDENT DILATION; OXIDATIVE STRESS;
   CARDIOVASCULAR RISK; CORONARY-ARTERIES; INFLAMMATORY CYTOKINES;
   LIPID-PEROXIDATION; GESTATIONAL-AGE
AB Growing evidence indicates that being small size at birth from malnutrition is associated with an increased risk of developing type 2 diabetes (T2D), metabolic syndrome and cardiovascular disease in adulthood. Atherosclerosis is common to these aforementioned disorders, and oxidative stress and chronic inflammation are now considered as initiating events in its development, with endothelial cell dysfunction being an early, fundamental step. According to the fetal programming hypothesis, growth-restricted neonates exposed to placental insufficiency exhibit endothelial cell dysfunction very early in life that later on predisposes them to atherosclerosis. Although many investigations have reported early alterations in vascular function in children and adolescents with low birth weight, the mechanisms of such fetal programming of atherosclerosis remain largely unknown. Experimental studies have demonstrated that low birth weight infants are prenatally subjected to conditions of oxidative stress and inflammation that might be involved in the later occurrence of atherosclerosis. Arterial endothelial dysfunction has been encountered in term infants, children and young adults with low birth weight. The loss of appropriate endothelium function with decreased nitric oxide production or activity, manifested as impaired vasodilatation, is considered a basic step in atherosclerosis development and progression. Several lines of evidence indicate that mitochondrial damage is central to this process and that reactive oxygen species (ROS) may act as a double-edged sword. On the one hand, it is well-accepted that the mitochondria are a major source of chronic ROS production under physiological conditions. On the other hand, it is known that ROS generation damages lipids, proteins and mitochondrial DNA, leading to dysregulated mitochondrial function. Elevated mitochondrial ROS production is associated with endothelial cell dysfunction as well as vascular smooth muscle cell proliferation and apoptosis. Smoking, obesity, insulin-resistant T2D, hypercholesterolemia, hyperglycaemia and hypertriglyceridaemia, major, traditional precursors of atherosclerosis, are all linked to mitochondrial dysfunction.
   This review focuses on proof of in utero programming resulting from chronic exposure to oxidative stress and inflammation as a cause of atherosclerosis. Endothelial cell dysfunction may be the initial injury arising from adverse antenatal conditions and responsible for the early changes in vascular function seen in children. After considering the critical role of the mitochondria in atherogenesis through endothelial function abnormalities, we propose that placental mitochondrial dysfunction is present in cases of placental insufficiency and may be critical in fetal programming of atherosclerosis. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
C1 [Leduc, Line] Univ Montreal, CHU St Justine, Dept Obstet & Gynaecol, Maternal Foetal Med Div,Res Ctr, Montreal, PQ H3T 1C5, Canada.
   [Levy, Emile; Bouity-Voubou, Maurice] Univ Montreal, CHU St Justine, Dept Nutr, Res Ctr, Montreal, PQ H3T 1C5, Canada.
   [Delvin, Edgard] Univ Montreal, CHU St Justine, Dept Biochem, Res Ctr, Montreal, PQ H3T 1C5, Canada.
C3 Universite de Montreal; Centre Hospitalier Universitaire Sainte-Justine;
   Universite de Montreal; Centre Hospitalier Universitaire Sainte-Justine;
   Universite de Montreal; Centre Hospitalier Universitaire Sainte-Justine
RP Leduc, L (corresponding author), Univ Montreal, CHU St Justine, Dept Obstet & Gynaecol, Maternal Foetal Med Div,Res Ctr, 3175 Cote Sainte Catherine, Montreal, PQ H3T 1C5, Canada.
EM l.leduc@umontreal.ca
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NR 54
TC 66
Z9 76
U1 1
U2 9
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0301-2115
EI 1872-7654
J9 EUR J OBSTET GYN R B
JI Eur. J. Obstet. Gynecol. Reprod. Biol.
PD APR
PY 2010
VL 149
IS 2
BP 127
EP 130
DI 10.1016/j.ejogrb.2009.12.005
PG 4
WC Obstetrics & Gynecology; Reproductive Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology; Reproductive Biology
GA 582TI
UT WOS:000276621400002
PM 20053495
DA 2025-06-11
ER

PT J
AU Younossi, ZM
   Stepanova, M
   Younossi, I
   Racila, A
AF Younossi, Zobair M.
   Stepanova, Maria
   Younossi, Issah
   Racila, Andrei
TI Validation of the Chronic Liver Disease Questionnaire for MASH
   (CLDQ-MASH)
SO JHEP REPORTS
LA English
DT Article
DE Chronic liver disease; Metabolic liver disease; NASH; NAFLD; Quality of
   life; MASH; MASLD
ID PATIENT-REPORTED OUTCOMES; QUALITY-OF-LIFE; BURDEN
AB Background & Aims: The new nomenclature for metabolic dysfunction-associated steatohepatitis (MASH) requires presence of steatohepatitis in the context of at least one cardiometabolic risk. Having a health-related quality of life (HRQL) instrument validated specifically in patients with MASH is important for clinical research and clinical trials. Methods: From our non-alcoholic fatty liver disease/non-alcoholic steatohepatitis (NAFLD/NASH) database, patients who met the definition of MASH according to the new criteria were selected. Subjects had completed the Chronic Liver Disease Questionnaire for NAFLD/NASH (CLDQ-NAFLD/NASH) and other HRQL instruments (Functional Assessment of Chronic Illness Therapy - Fatigue [FACIT-F], Short-Form 36 [SF-36]), and had available clinico-laboratory data including fibrosis non-invasive tests (NITs). The CLDQ-MASH was developed following a standard pipeline and subsequently validated in a non-overlapping sample. Results: There were 4,213 MASH patients included: age 56 +/- 11 years, 44% male, 65% type 2 diabetes, 69% advanced fibrosis (F3-F4). The patients with MASH were split 1:2 into a training set used for development of CLDQ-MASH and a testing set used for validation using standard pipeline. After item reduction and exploratory factor analysis with the training set (>90% variance), the CLDQ-MASH contained 35 items and seven domains. With the non-overlapping testing set, CLDQ-MASH demonstrated excellent face validity, internal consistency (all Cronbach's alpha >0.78), and high correlations with relevant domains of SF-36, FACIT-F (p <0.01). Known-groups validity assessment confirmed that CLDQ-MASH can discriminate patients based on liver disease severity (histology- and NIT-based) and the presence of non-hepatic comorbidities (obesity, type 2 diabetes, depression, clinically overt fatigue, insomnia). In a subsample of subjects with 1-year follow-up, the instrument was responsive to changes in Enhanced Liver Fibrosis (R) scores and liver stiffness measurements (p <0.05 for four to six domains). Conclusions: The CLDQ-MASH can be used as a valid disease-specific HRQL instrument for patients with MASH.
C1 [Younossi, Zobair M.] Ctr Outcomes Res Liver Dis, 2411 I St NW, Washington, DC 20037 USA.
RP Younossi, ZM (corresponding author), Ctr Outcomes Res Liver Dis, 2411 I St NW, Washington, DC 20037 USA.
EM zobair.younossi@cldq.org
RI Younossi, Zobair M./JRY-9916-2023
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NR 31
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
EI 2589-5559
J9 JHEP REP
JI JHEP Rep.
PD MAR
PY 2025
VL 7
IS 3
AR 101276
DI 10.1016/j.jhepr.2024.101276
PG 11
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA W8V7F
UT WOS:001421285200001
PM 39980748
OA gold
DA 2025-06-11
ER

PT J
AU Pongkan, W
   Jitnapakarn, W
   Phetnoi, W
   Punyapornwithaya, V
   Boonyapakorn, C
AF Pongkan, Wanpitak
   Jitnapakarn, Wannida
   Phetnoi, Warunee
   Punyapornwithaya, Veerasak
   Boonyapakorn, Chavalit
TI Obesity-Induced Heart Rate Variability Impairment and Decreased Systolic
   Function in Obese Male Dogs
SO ANIMALS
LA English
DT Article
DE obesity; oxidative stress; cardiac function; heart rate variability; dog
ID MITRAL-VALVE DISEASE; OXIDATIVE STRESS; BLOOD-PRESSURE; HEALTHY;
   MITOCHONDRIA; VILDAGLIPTIN; PARAMETERS; RESISTANCE; MARKERS; STATE
AB Simple Summary Obesity in dogs can induce many adverse health effects including musculoskeletal problems, respiratory distress, metabolic syndrome, and cardiovascular diseases. In humans with obesity, heart rate variability (HRV) is used to identify and predict the risk of cardiovascular diseases. However, this predictive tool has never been used in veterinary medicine, and the relationship between obesity and HRV has rarely been investigated. In this study, we investigated HRV, plasma oxidative stress (MDA), and cardiac function in obese male dogs. We hypothesized that obese male dogs have decreased cardiac function and impaired HRV compared to non-obese dogs. Our study found that obese dogs have decreased cardiac systolic function and impaired HRV, as indicated by reduced percentages of cardiac contraction and impaired cardiac autonomic activity compared to non-obese dogs. We concluded that obesity can decrease systolic function and cause HRV impairment, which might increase the risk of cardiovascular disease in dogs. In addition, HRV might be used as a predictive or prognostic tool in the prevention of cardiovascular disease in obese dogs. Obesity can induce cardiovascular diseases in both humans and animals. Heart rate variability (HRV) is an indicator of sympathovagal balance and is used to identify cardiovascular diseases in humans. However, HRV and cardiac function have rarely been investigated in obese dogs. This study investigated the effect of obesity on oxidative stress, HRV, and cardiac function in obese and non-obese dogs. The nine-scale body condition score (BCS) system was used to determine obesity. Thirty small breed dogs were divided into a normal weight group (n= 15) and an obese group (n= 15). All dogs underwent physical examination, plasma malondialdehyde (MDA) measurement, electrocardiography, echocardiography, and two hours of Holter monitoring. This study found that obese dogs had increased plasma MDA and sympathovagal imbalance, which was indicated by impaired time and frequency domains compared to normal weight dogs. Although cardiac function was within normal limits, the echocardiographic study found that the obese dogs had reduced cardiac wall thickness and lower systolic function, as indicated by a reduction in %ejection fraction, %fractional shortening, increased left ventricular (LV) internal diameter during systole, and LV end-systolic volume compared to normal weight dogs. This study concluded that obesity in dogs can induce increased plasma oxidative stress, impaired HRV, and reduced cardiac systolic function compared to non-obese dogs.
C1 [Pongkan, Wanpitak; Jitnapakarn, Wannida; Phetnoi, Warunee] Chiang Mai Univ, Fac Vet Med, Dept Vet Biosci & Vet Publ Hlth, Chiang Mai 50100, Thailand.
   [Pongkan, Wanpitak; Boonyapakorn, Chavalit] Chiang Mai Univ, Fac Vet Med, Integrat Res Ctr Vet Circulatory Sci, Chiang Mai 50100, Thailand.
   [Pongkan, Wanpitak; Boonyapakorn, Chavalit] Chiang Mai Univ, Small Anim Hosp, Fac Vet Med, Vet Cardiopulm Clin, Chiang Mai 50100, Thailand.
   [Punyapornwithaya, Veerasak] Chiang Mai Univ, Fac Vet Med, Dept Food Anim Clin, Chiang Mai 50100, Thailand.
   [Boonyapakorn, Chavalit] Chiang Mai Univ, Fac Vet Med, Dept Compan Anim & Wildlife Clin, Chiang Mai 50100, Thailand.
C3 Chiang Mai University; Chiang Mai University; Chiang Mai University;
   Chiang Mai University; Chiang Mai University
RP Boonyapakorn, C (corresponding author), Chiang Mai Univ, Fac Vet Med, Integrat Res Ctr Vet Circulatory Sci, Chiang Mai 50100, Thailand.; Boonyapakorn, C (corresponding author), Chiang Mai Univ, Small Anim Hosp, Fac Vet Med, Vet Cardiopulm Clin, Chiang Mai 50100, Thailand.; Boonyapakorn, C (corresponding author), Chiang Mai Univ, Fac Vet Med, Dept Compan Anim & Wildlife Clin, Chiang Mai 50100, Thailand.
EM p.wanpitak@gmail.com; wannida.jpk@yahoo.com; kiriten10@gmail.com;
   pveerasak.r@gmail.com; chavalit.b@cmu.ac.th
RI Punyapornwithaya, Verasak/V-9323-2019; boonyapakorn,
   chavalit/KVZ-2226-2024; Pongkan, Wanpitak/N-8420-2018
OI Punyapornwithaya, Veerasak/0000-0001-9870-7773; Pongkan,
   Wanpitak/0000-0001-6788-7740
FU Chiang Mai University (CMU); Integrative Research Center for Veterinary
   Circulatory Sciences, Chiang Mai University [R000023425]; Faculty of
   Veterinary Medicine, Chiang Mai University
FX This work was partially supported by Chiang Mai University (CMU), which
   provided funding through the Integrative Research Center for Veterinary
   Circulatory Sciences, Chiang Mai University, grant number R000023425
   (W.P., C.B.) and the Faculty of Veterinary Medicine, Chiang Mai
   University (W.P., C.B.).
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NR 63
TC 11
Z9 12
U1 4
U2 25
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 2076-2615
J9 ANIMALS-BASEL
JI Animals
PD AUG
PY 2020
VL 10
IS 8
AR 1383
DI 10.3390/ani10081383
PG 15
WC Agriculture, Dairy & Animal Science; Veterinary Sciences; Zoology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture; Veterinary Sciences; Zoology
GA NH6YD
UT WOS:000564812800001
PM 32785083
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Salpea, KD
   Talmud, PJ
   Cooper, JA
   Maubaret, CG
   Stephens, JW
   Abelak, K
   Humphries, SE
AF Salpea, Klelia D.
   Talmud, Philippa J.
   Cooper, Jackie A.
   Maubaret, Cecilia G.
   Stephens, Jeffrey W.
   Abelak, Kavin
   Humphries, Steve E.
TI Association of telomere length with type 2 diabetes, oxidative stress
   and UCP2 gene variation
SO ATHEROSCLEROSIS
LA English
DT Article
DE Telomere length; Type 2 diabetes; Oxidative stress; UCP2 gene; Ethnic
   diversity
ID PREMATURE MYOCARDIAL-INFARCTION; CORONARY-ARTERY-DISEASE; UNCOUPLING
   PROTEIN-2; DNA-DAMAGE; METABOLIC SYNDROME; CIGARETTE-SMOKING; HUMAN
   FIBROBLASTS; HEART-DISEASE; VITAMIN-E; RISK
AB Objective: High oxidative stress potentially leads to accelerated telomere shortening and consequent premature cell senescence, implicated in type 2 diabetes (T2D) development. Therefore, we studied the association of leukocyte telomere length (LTL) with the presence of T2D, as well as the effect on the patients' LTL of plasma oxidative stress and of variation in UCP2, a gene involved in the mitochondrial production of reactive oxygen species.
   Methods: Mean LTL was determined in 569 Caucasian, 103 South Asian and 70 Afro-Caribbean T2D patients aged from 24 to 92 years, 81 healthy Caucasian male students aged from 18 to 28 years and 367 healthy Caucasian men aged from 40 to 61 years by real-time PCR. Plasma total antioxidant status (TAOS) was measured in the T2D patients by a photometric microassay. The patients were also genotyped for the UCP2 functional variants -866G>A and A55V.
   Results: Afro-Carribeans had 510 bp longer mean length compared to Caucasians (p < 0.0001) and 500 bp longer than South Asians (p = 0.004). T2D subjects displayed shorter age-adjusted LTL compared to controls [6.94(6.8-7.03) vs. 7.72(7.53-7.9), p < 0.001] with subjects in the middle and the lowest tertile of LTL having significantly higher odds ratios for T2D compared to those in the highest tertile [1.50(1.08-2.07) and 5.04(3.63-6.99), respectively, p < 0.0001]. In the patients, LTL was correlated negatively with age (r = -0.18, p < 0.0001) and positively with TAOS measures (r = 0.12, p = 0.01) after adjusting for age, while carriers of the UCP2 -866A allele had shorter age-adjusted LTL than common homozygotes [6.86(6.76-6.96) kb vs. 7.03(6.91-7.15) kb, p = 0.04].
   Conclusion: The present data suggest that shorter LTL is associated with the presence of T2D and this could be partially attributed to the high oxidative stress in these patients. The association of the UCP2 functional promoter variant with the LTL implies a link between mitochondrial production of reactive oxygen species and shorter telomere length in T2D. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
C1 [Salpea, Klelia D.; Talmud, Philippa J.; Cooper, Jackie A.; Maubaret, Cecilia G.; Abelak, Kavin; Humphries, Steve E.] Royal Free & Univ Coll Med Sch, British Heart Fdn Labs, Dept Med, Ctr Cardiovasc Genet, London WC1E 6JF, England.
   [Stephens, Jeffrey W.] Swansea Univ, Inst Life Sci, Diabet Res Grp, Swansea SA2 8PP, W Glam, Wales.
C3 University of London; University College London; Swansea University
RP Salpea, KD (corresponding author), Royal Free & Univ Coll Med Sch, British Heart Fdn Labs, Dept Med, Ctr Cardiovasc Genet, Rayne Bldg,5 Univ St, London WC1E 6JF, England.
EM k.salpea@ucl.ac.uk
RI Humphries, Stephen/C-5075-2008; Talmud, Philippa/C-4402-2008; SALPEA,
   Klelia/LVS-1562-2024
OI Humphries, Stephen E/0000-0002-8221-6547; Talmud,
   Philippa/0000-0002-5560-1933
FU British Heart Foundation [FS/06/053, RG2005/014]; Diabetes UK
FX Weacknowledge the British Heart Foundation for funding Klelia D. Salpea
   (FS/06/053), Jackie A. Cooper and Steve E. Humphries (RG2005/014).
   Financial support for UDACS was provided by the Diabetes UK.
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NR 48
TC 223
Z9 241
U1 0
U2 15
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0021-9150
J9 ATHEROSCLEROSIS
JI Atherosclerosis
PD MAR
PY 2010
VL 209
IS 1
BP 42
EP 50
DI 10.1016/j.atherosclerosis.2009.09.070
PG 9
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 563BV
UT WOS:000275101500008
PM 19889414
OA Green Published
DA 2025-06-11
ER

PT J
AU Xing, B
   Yu, J
   Liu, Y
   He, S
   Chen, X
   Li, Z
   He, L
   Yang, N
   Ping, F
   Xu, L
   Li, W
   Zhang, H
   Li, Y
AF Xing, B.
   Yu, J.
   Liu, Y.
   He, S.
   Chen, X.
   Li, Z.
   He, L.
   Yang, N.
   Ping, F.
   Xu, L.
   Li, W.
   Zhang, H.
   Li, Y.
TI High Dietary Zinc Intake Is Associated with Shorter Leukocyte Telomere
   Length, Mediated by Tumor Necrosis Factor-α: A Study of China Adults
SO JOURNAL OF NUTRITION HEALTH & AGING
LA English
DT Article
DE Dietary zinc intake; leukocyte telomere length; inflammation; oxidative
   stress
ID METABOLIC SYNDROME; SUPPLEMENTATION; DISEASE; IRON
AB Objectives Diet can influence peripheral leukocyte telomere length (LTL), and various micronutrients have been reported to correlate with it. Zinc is known for its antioxidant properties and immunomodulatory effects. However, there are few epidemiological investigations on the relationship between dietary zinc intake and LTL. This study analyzed the association between dietary zinc and LTL and the potential role of inflammation and oxidative stress among them.Design Cross-sectional and community-based study.Setting and Participants 599 participants from rural communities in the Changping suburb of Beijing, China, were recruited.Measurements Serum lipid profile, glycosylated hemoglobin (HbA1c), oxidative stress marker, and inflammatory cytokines levels were measured. Detailed dietary data were obtained using a 24 h food recall. LTL was assessed using a real-time PCR assay. Spearman analysis, restricted cubic splines (RCS), and general linear regression models were used to determine the association between dietary zinc intake and LTL. Simple regulatory models were also applied to analyze the role of inflammation and oxidative stress among them.Results A total of 482 subjects were ultimately included in this analysis. Spearman analysis showed that dietary zinc intake and zinc intake under energy density were negatively correlated with LTL (r=-0.142 and -0.126, all P <0.05) and positively correlated with tumor necrosis factor-alpha (TNF-alpha) (r=0.138 and 0.202, all P <0.05) while only dietary zinc without energy adjustment had a positive correlation with superoxide dismutase (SOD). RCS (P for non-linearity=0.933) and multiple linear regression (B=-0.084, P=0.009) indicated a negative linear association between dietary zinc and LTL. The adjustment of TNF-alpha rather than SOD could abolish the relationship. The mediation model suggested that the unfavorable effect of dietary zinc on LTL was mediated by TNF-alpha.Conclusions High dietary zinc may correlate with telomere attrition, and TNF-alpha can act as a mediator in this relationship. In the future, more extensive cohort studies are needed to further explore the relationship between dietary zinc and cellular aging and the specific mechanisms.
C1 [Xing, B.; Yu, J.; Liu, Y.; Chen, X.; Li, Z.; He, L.; Yang, N.; Ping, F.; Xu, L.; Li, W.; Zhang, H.; Li, Y.] Chinese Acad Med Sci & Peking Union Med Coll, Dept Endocrinol, Peking Union Med Coll Hosp, Translat Med Ctr,Key Lab Endocrinol Natl Hlth Com, Beijing, Peoples R China.
   [He, S.] Chinese Acad Med Sci & Peking Union Med Coll, Dept Nutr, Peking Union Med Coll Hosp, Beijing, Peoples R China.
C3 Chinese Academy of Medical Sciences - Peking Union Medical College;
   Peking Union Medical College; Peking Union Medical College Hospital;
   Chinese Academy of Medical Sciences - Peking Union Medical College;
   Peking Union Medical College; Peking Union Medical College Hospital
RP Li, W; Zhang, H; Li, Y (corresponding author), Chinese Acad Med Sci & Peking Union Med Coll, Dept Endocrinol, Peking Union Med Coll Hosp, Translat Med Ctr,Key Lab Endocrinol Natl Hlth Com, Beijing, Peoples R China.
EM liw@pumch.cn; huabingzhangchn@163.com; liyuxiu@medmail.com.cn
RI Li, Wei/JDD-4293-2023; Xing, Baodi/KUF-0673-2024; He,
   Liyun/HRA-0769-2023
OI Li, Wei/0000-0002-3332-1287; He, Liyun/0000-0002-2450-791X
FU We are grateful to all of the participants in this study. The authors'
   responsibilities were as follows-BD Xing, HB Zhang, YX Li: designed the
   research; BD Xing, J Yu, YW Liu, XY Chen, ZY Li, LY He, N Yang: helped
   to organize the data; SLH: calculated the
FX We are grateful to all of the participants in this study. The authors'
   responsibilities were as follows-BD Xing, HB Zhang, YX Li: designed the
   research; BD Xing, J Yu, YW Liu, XY Chen, ZY Li, LY He, N Yang: helped
   to organize the data; SLH: calculated the nutrient related data; BD
   Xing, J Yu, HB Zhang analyzed the data; BD Xing wrote the paper; LL Xu,
   F Ping, W Li gave instruction to data analyses: W Li and YX Li reviewed
   and edited the manuscript. All authors read and approved the final
   manuscript.
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NR 44
TC 4
Z9 4
U1 0
U2 7
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1279-7707
EI 1760-4788
J9 J NUTR HEALTH AGING
JI J. Nutr. Health Aging
PD OCT
PY 2023
VL 27
IS 10
BP 904
EP 910
DI 10.1007/s12603-023-1992-z
EA JAN 2024
PG 7
WC Geriatrics & Gerontology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology; Nutrition & Dietetics
GA X9QV1
UT WOS:001101722200015
PM 37960914
OA hybrid
DA 2025-06-11
ER

PT J
AU Delacrétaz, A
   Vandenberghe, F
   Gholam-Rezaee, M
   Morgui, NS
   Glatard, A
   Thonney, J
   Solida-Tozzi, A
   Kolly, S
   Gallo, SF
   Baumann, P
   Berney, S
   Zulauff, SV
   Aubry, JM
   Hasler, R
   Ebbing, K
   von Gunten, A
   Conus, P
   Eap, CB
AF Delacretaz, Aurelie
   Vandenberghe, Frederik
   Gholam-Rezaee, Mehdi
   Morgui, Nuria Saigi
   Glatard, Anais
   Thonney, Jacques
   Solida-Tozzi, Alessandra
   Kolly, Stephane
   Gallo, Sylfa Fassassi
   Baumann, Philipp
   Berney, Sylvie
   Zulauff, Sandrine Valloton
   Aubry, Jean-Michel
   Hasler, Roland
   Ebbing, Karsten
   von Gunten, Armin
   Conus, Philippe
   Eap, Chin B.
TI Early changes of blood lipid levels during psychotropic drug treatment
   as predictors of long-term lipid changes and of new onset dyslipidemia
SO JOURNAL OF CLINICAL LIPIDOLOGY
LA English
DT Article
DE Early lipid changes; Predictors; Metabolic follow-up; New onset
   dyslipidemia; Psychotropic drugs
ID BODY-MASS INDEX; CARDIOVASCULAR MORTALITY; CARDIOMETABOLIC RISK;
   ANTIPSYCHOTIC-DRUGS; BIPOLAR DISORDER; LIFE EXPECTANCY; WEIGHT-GAIN;
   SCHIZOPHRENIA; MEDICATIONS; DEPRESSION
AB BACKGROUND: Cardiovascular diseases and dyslipidemia represent a major health issue in psychiatry. Many psychotropic drugs can induce a rapid and substantial increase of blood lipid levels.
   OBJECTIVE: This study aimed to determine the potential predictive power of an early change of blood lipid levels during psychotropic treatment on long-term change and on dyslipidemia development.
   METHODS: Data were obtained from a prospective study including 181 psychiatric patients with metabolic parameters monitored during the first year of treatment and with adherence ascertained. Blood lipid levels (ie, total cholesterol [TC], low-density lipoprotein cholesterol [LDL-C], high-density lipoprotein cholesterol [HDL-C], non-high-density lipoprotein cholesterol [non-HDL-C], and fasting triglycerides [TGs]) were measured at baseline and after 1, 3, and/or 12 months of treatment.
   RESULTS: Receiver-operating characteristic analyses indicated that early (ie, after 1 month of psycho tropic treatment) increases (5%) for TC, LDL-C, TG, and non-HDL-C and decrease (>= 5%) for HDL-C were the best predictors for clinically relevant modifications of blood lipid levels after 3 months of treatment (>= 30% TC, >= 40% LDL-C, >= 45% TG, >= 55% non-HDL-C increase, and >= 20% HDL-C decrease; sensitivity 70%-100%, specificity 53%-72%). Predictive powers of these models were confirmed by fitting longitudinal multivariate models in the same cohort (P <= .03) as well as in a replication cohort (n = 79; P <= .003). Survival models showed significantly higher incidences of new onset dyslipidemia (TC, LDL-C, and non-HDL-C hypercholesterolemia, HDL-C hypocholesterolemia, and hypertriglyceridemia) for patients with early changes of blood lipid levels compared to others (P <= .01).
   CONCLUSION: Early modifications of blood lipid levels following prescription of psychotropic drugs inducing dyslipidemia should therefore raise questions on clinical strategies to control long-term dyslipidemia. (C) 2017 National Lipid Association. Published by Elsevier Inc.
C1 [Delacretaz, Aurelie; Vandenberghe, Frederik; Morgui, Nuria Saigi; Glatard, Anais; Eap, Chin B.] Lausanne Univ Hosp, Unit Pharmacogenet & Clin Psychopharmacol, Ctr Psychiat Neurosci, Dept Psychiat, Prilly, Switzerland.
   [Delacretaz, Aurelie; Vandenberghe, Frederik; Morgui, Nuria Saigi; Glatard, Anais; Eap, Chin B.] Lausanne Univ Hosp, Prilly, Switzerland.
   [Gholam-Rezaee, Mehdi] Lausanne Univ Hosp, Dept Psychiat, Ctr Psychiat Epidemiol & Psychopathol, Prilly, Switzerland.
   [Thonney, Jacques; Solida-Tozzi, Alessandra; Kolly, Stephane; Gallo, Sylfa Fassassi; Baumann, Philipp; Berney, Sylvie; Zulauff, Sandrine Valloton; Conus, Philippe] Lausanne Univ Hosp, Dept Psychiat, Serv Gen Psychiat, Prilly, Switzerland.
   [Aubry, Jean-Michel; Hasler, Roland] Univ Hosp Geneva, Div Psychiat Specialties, Geneva, Switzerland.
   [Ebbing, Karsten; von Gunten, Armin] Lausanne Univ Hosp, Serv Old Age Psychiat, Dept Psychiat, Prilly, Switzerland.
   [Eap, Chin B.] Univ Lausanne, Univ Geneva, Sch Pharmaceut Sci, Geneva, Switzerland.
C3 University of Geneva; University of Lausanne; University of Geneva
RP Eap, CB (corresponding author), Hop Cery, 1008 Prilly, Lausanne, Switzerland.
EM chin.eap@chuv.ch
RI Frederik, Vandenberghe/IQW-5168-2023
OI Berney, Sylvie/0000-0001-7099-6999; Vandenberghe,
   Frederik/0000-0002-8964-2047; Saigi, Nuria/0000-0003-2503-1818; Conus,
   Philippe/0000-0002-5832-1910; von Gunten, Armin/0000-0001-7852-3803;
   Kolly, Stephane/0000-0001-9128-2821; HASLER, Roland/0000-0001-5929-1250
FU Swiss National Research Foundation [320030-120686, 324730-144064,
   320030-173211]; Swiss National Science Foundation (SNF) [324730_144064,
   320030_173211] Funding Source: Swiss National Science Foundation (SNF)
FX This work has been funded in part by the Swiss National Research
   Foundation (C.B.E. and P.C.: 320030-120686, 324730-144064, and
   320030-173211). The funding sources had no role in the writing of the
   manuscript or in the decision to submit it for publication.
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NR 39
TC 19
Z9 21
U1 0
U2 4
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1933-2874
EI 1876-4789
J9 J CLIN LIPIDOL
JI J. Clin. Lipidol.
PD FEB
PY 2018
VL 12
IS 1
BP 219
EP 229
DI 10.1016/j.jacl.2017.10.002
PG 11
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Pharmacology & Pharmacy
GA FX4DH
UT WOS:000426022400027
PM 29128242
OA Green Published, Green Accepted, hybrid
DA 2025-06-11
ER

PT J
AU van 't Erve, TJ
   Kadiiska, MB
   London, SJ
   Mason, RP
AF van 't Erve, Thomas J.
   Kadiiska, Maria B.
   London, Stephanie J.
   Mason, Ronald P.
TI Classifying oxidative stress by F2-isoprostane levels across
   human diseases: A meta-analysis
SO REDOX BIOLOGY
LA English
DT Article
DE Meta-analysis; Oxidative stress; Oxidative damage; F-2-isoprostane;
   Ranking
ID EXHALED BREATH CONDENSATE; OBSTRUCTIVE SLEEP-APNEA; 8-EPI-PROSTAGLANDIN
   F-2 ALPHA; ENHANCED LIPID-PEROXIDATION; CORONARY-ARTERY-DISEASE; FATTY
   LIVER-DISEASE; INCREASED URINARY F-2-ISOPROSTANES; BRONCHOALVEOLAR
   LAVAGE FLUID; PHOSPHOLIPASE A(2) ACTIVITY; PLASMA 8-ISOPROSTANE LEVELS
AB The notion that oxidative stress plays a role in virtually every human disease and environmental exposure has become ingrained in everyday knowledge. However, mounting evidence regarding the lack of specificity of biomarkers traditionally used as indicators of oxidative stress in human disease and exposures now necessitates re-evaluation. To prioritize these re-evaluations, published literature was comprehensively analyzed in a meta-analysis to quantitatively classify the levels of systemic oxidative damage across human disease and in response to environmental exposures.
   In this meta-analysis, the F-2-isoprostane, 8-iso-PGF(2 alpha), was specifically chosen as the representative marker of oxidative damage. To combine published values across measurement methods and specimens, the standardized mean differences (Hedges' g) in 8-iso-PGF(2 alpha) levels between affected and control populations were calculated.
   The meta-analysis resulted in a classification of oxidative damage levels as measured by 8-iso-PGF(2 alpha) across 50 human health outcomes and exposures from 242 distinct publications. Relatively small increases in 8-iso-PGF(2 alpha) levels (g < 0.8) were found in the following conditions: hypertension (g = 0.4), metabolic syndrome (g = 0.5), asthma (g = 0.4), and tobacco smoking (g = 0.7). In contrast, large increases in 8-iso-PGF(2 alpha) levels were observed in pathologies of the kidney, e.g., chronic renal insufficiency (g = 1.9), obstructive sleep apnoea (g = 1.1), and pre-eclampsia (g = 1.1), as well as respiratory tract disorders, e. g., cystic fibrosis (g = 2.3).
   In conclusion, we have established a quantitative classification for the level of 8-iso-PGF(2 alpha) generation in different human pathologies and exposures based on a comprehensive meta-analysis of published data. This analysis provides knowledge on the true involvement of oxidative damage across human health outcomes as well as utilizes past research to prioritize those conditions requiring further scrutiny on the mechanisms of biomarker generation.
C1 [van 't Erve, Thomas J.; Kadiiska, Maria B.; London, Stephanie J.; Mason, Ronald P.] NIEHS, Immun Inflammat & Dis Lab, POB 12233, Res Triangle Pk, NC 27709 USA.
   [London, Stephanie J.] NIEHS, Epidemiol Branch, Res Triangle Pk, NC 27709 USA.
C3 National Institutes of Health (NIH) - USA; NIH National Institute of
   Environmental Health Sciences (NIEHS); National Institutes of Health
   (NIH) - USA; NIH National Institute of Environmental Health Sciences
   (NIEHS)
RP van 't Erve, TJ (corresponding author), NIEHS, Immun Inflammat & Dis Lab, POB 12233, Res Triangle Pk, NC 27709 USA.
EM thomas.vanterve@nih.gov
RI Kadiiska, Maria/AAC-9981-2019; London, Stephanie/C-3734-2019
OI London, Stephanie/0000-0003-4911-5290; van 't Erve,
   Thomas/0000-0002-3260-6627
FU National Institutes of Health, National Institute of Environmental
   Health Sciences [Z01 ES048012-08]
FX The authors gratefully acknowledge Dr. Shyamal Peddada for his valuable
   feedback on the statistics; Drs. Kelly K. Ferguson and Ashutosh Kumar
   for their review of this manuscript; and Jean Corbett, Dr. Ann Motten,
   and Mary Mason for their editorial expertise. This work was supported by
   the Intramural Research Program, National Institutes of Health, National
   Institute of Environmental Health Sciences (Z01 ES048012-08).
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NR 261
TC 134
Z9 142
U1 0
U2 28
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2213-2317
J9 REDOX BIOL
JI Redox Biol.
PD AUG
PY 2017
VL 12
BP 582
EP 599
DI 10.1016/j.redox.2017.03.024
PG 18
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA EX6CA
UT WOS:000403328700055
PM 28391180
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU John, A
   Howarth, FC
   Raza, H
AF John, Annie
   Howarth, Frank Christopher
   Raza, Haider
TI Exercise alleviates diabetic complications by inhibiting oxidative
   stress-mediated signaling cascade and mitochondrial metabolic stress in
   GK diabetic rat tissues
SO FRONTIERS IN PHYSIOLOGY
LA English
DT Article
DE type 2 diabetes; GK rat tissues; exercise; ROS; mitochondria; energy
   metabolism
ID NF-KAPPA-B; LIVER; HOMEOSTASIS; ASPIRIN; AMPK
AB Type 2 diabetes, obesity (referred to as "diabesity "), and metabolic syndrome associated with increased insulin resistance and/or decreased insulin sensitivity have been implicated with increased oxidative stress and inflammation, mitochondrial dysfunction, and alterations in energy metabolism. The precise molecular mechanisms of these complications, however, remain to be clarified. Owing to the limitations and off-target side effects of antidiabetic drugs, exercise-induced control of hyperglycemia and increased insulin sensitivity is a preferred strategy to manage "diabesity " associated complications. In this study, we have investigated the effects of moderate exercise (1 h/day, 5 days a week for 60 days) on mitochondrial, metabolic, and oxidative stress-related changes in the liver and kidney of type 2 diabetic Goto-Kakizaki (GK) rats. Our previous study, using the same exercise regimen, demonstrated improved energy metabolism and mitochondrial function in the pancreas of GK diabetic rats. Our current study demonstrates exercise-induced inhibition of ROS production and NADPH oxidase enzyme activity, as well as lipid peroxidation and protein carbonylation in the liver and kidney of GK rats. Interestingly, glutathione (GSH) content and GSH-peroxidase and GSH reductase enzymes as well as superoxide dismutase (SOD) activities were profoundly altered in diabetic rat tissues. Exercise helped in restoring the altered GSH metabolism and antioxidant homeostasis. An increase in cytosolic glycolytic enzyme, hexokinase, and a decrease in mitochondrial Kreb's cycle enzyme was observed in GK diabetic rat tissues. Exercise helped restore the altered energy metabolism. A significant decrease in the activities of mitochondrial complexes and ATP content was also observed in the GK rats and exercise regulated the activities of the respiratory complexes and improved energy utilization. Activation of cytochrome P450s, CYP 2E1, and CYP 3A4 was observed in the tissues of GK rats, which recovered after exercise. Altered expression of redox-responsive proteins and translocation of transcription factor NF kappa B-p65, accompanied by activation of AMP-activated protein kinase (AMPK), SIRT-1, Glut-4, and PPAR-gamma suggests the induction of antioxidant defense responses and increased energy metabolism in GK diabetic rats after exercise.
C1 [John, Annie; Raza, Haider] United Arab Emirates Univ, Coll Med & Hlth Sci, Dept Biochem & Mol Biol, Al Ain, U Arab Emirates.
   [Howarth, Frank Christopher] United Arab Emirates Univ, Coll Med & Hlth Sci, Dept Physiol, Al Ain, U Arab Emirates.
C3 United Arab Emirates University; United Arab Emirates University
RP Raza, H (corresponding author), United Arab Emirates Univ, Coll Med & Hlth Sci, Dept Biochem & Mol Biol, Al Ain, U Arab Emirates.
EM h.raza@uaeu.ac.ae
FU Research Committee (HR), College of Medicine and Health Sciences, UAE
   University, U.A.E [NP-15/03]
FX The authors would like to acknowledge the financial research grant
   (NP-15/03) from the Research Committee (HR), College of Medicine and
   Health Sciences, UAE University, U.A.E. The funders had no role in the
   study design; collection, analysis, and interpretation of data; in the
   writing of the manuscript; and in the decision to submit the article for
   publication.
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NR 50
TC 8
Z9 9
U1 0
U2 9
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1664-042X
J9 FRONT PHYSIOL
JI Front. Physiol.
PD DEC 1
PY 2022
VL 13
AR 1052608
DI 10.3389/fphys.2022.1052608
PG 15
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA 7B5VO
UT WOS:000899200700001
PM 36531176
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Tseng, SH
   Liu, LK
   Peng, LN
   Wang, PN
   Loh, CH
   Chen, LK
AF Tseng, S-H
   Liu, L-K
   Peng, L-N
   Wang, P-N
   Loh, C-H
   Chen, L-K
TI DEVELOPMENT AND VALIDATION OF A TOOL TO SCREEN FOR COGNITIVE FRAILTY
   AMONG COMMUNITY-DWELLING ELDERS
SO JOURNAL OF NUTRITION HEALTH & AGING
LA English
DT Article
DE Cognitive frailty; screen; tool; community; elder; age
ID HEALTH; RISK; CIRCUMFERENCE; PREVALENCE; FRAMEWORK; OUTCOMES; SOCIETY;
   STATE; MOCA; MASS
AB Objectives: Reciprocal age-related impairments in physical and cognitive functioning have been termed 'cognitive frailty', which is associated with adverse health outcomes and is a potential target for preventing or delaying the onset of disability in older people. However, cognitive frailty as currently defined is challenging to diagnose. To facilitate earlier diagnosis and intervention, we conducted this study to develop and validate a simple evidence-based instrument to identify community-dwelling elders at risk of cognitive frailty. Design: Retrospective analyses of data from the I-Lan Longitudinal Aging Study (ILAS) to develop a prediction model, and from the Longitudinal Aging Study of Taipei (LAST) for external validation.Setting: Community-dwelling adults from Taipei City, New Taipei City and Yilan (I-Lan) County, Taiwan. Participants: 1271 community residents >= 65 years old, without impaired global cognition or dependency for activities of daily living/instrumental activities of daily living. Measurements: Demographic characteristics, anthropometric measurements, medical history, Mini-Mental State Examination, Montreal Cognitive Assessment, Functional Autonomy Measuring System, Functional Assessment Staging Test, Center for Epidemiologic Studies Depression Scale, handgrip strength, 6-metre walk speed.Methods: Baseline characteristics of groups with/without cognitive frailty were analyzed and factors differing significantly in univariate analysis input to binary logistic regression to develop a cognitive frailty risk (CFR) score.ResultsThe prevalence of cognitive frailty was 15.8% overall; ILAS 21.4%, LAST 8.4%. Predictors of CFR comprised: age >= 75 years; female sex; waist circumference >= 90 cm (male), >= 80 cm (female); calf circumference <33 cm (male), <32 cm (female); memory deficits; and diabetes mellitus. CFR >= 5/14 had sensitivity of 70%, specificity of 60%, and predictive accuracy of 72%. Conclusions: A CFR score based on simple history-taking and anthropometric measurements integrates age, sex, cardiometabolic risk, memory deficits, sarcopenia, and nutrition, with validated predictive accuracy, and could be performed easily in community settings to identify seniors with cognitive frailty for appropriate interventions.
C1 [Tseng, S-H; Liu, L-K; Peng, L-N; Chen, L-K] Taipei Vet Gen Hosp, Ctr Geriatr & Gerontol, 201,Sec 2,Shih Pai Rd, Taipei 11217, Taiwan.
   [Tseng, S-H; Liu, L-K; Peng, L-N; Wang, P-N; Chen, L-K] Natl Yang Ming Univ, Aging & Hlth Res Ctr, Taipei, Taiwan.
   [Liu, L-K; Peng, L-N; Chen, L-K] Natl Yang Ming Univ, Dept Geriatr Med, Taipei, Taiwan.
   [Wang, P-N] Taipei Vet Gen Hosp, Dept Neurol, Taipei, Taiwan.
   [Loh, C-H] Hualien Tzu Chi Hosp, Ctr Hlth & Aging, Hualien, Taiwan.
   [Tseng, S-H] Taipei Med Univ Hosp, Div Geriatr Med, Dept Prevent & Community Med, Taipei, Taiwan.
C3 Taipei Veterans General Hospital; National Yang Ming Chiao Tung
   University; National Yang Ming Chiao Tung University; Taipei Veterans
   General Hospital; Buddhist Tzu Chi General Hospital; Hualien Tzu Chi
   Hospital; Taipei Medical University Hospital; Taipei Medical University
RP Peng, LN; Chen, LK (corresponding author), Taipei Vet Gen Hosp, Ctr Geriatr & Gerontol, 201,Sec 2,Shih Pai Rd, Taipei 11217, Taiwan.
EM lining.peng@gmail.com; lkchen2@vghtpe.gov.tw
RI Chen, Liang-Kung/JBI-8802-2023
OI Chen, Liang-Kung/0000-0002-2387-8508
FU Ministry of Science and Technology, Taiwan [MOST-108-2634-F-010-001];
   Taipei Veterans General Hospital [107VACS-001]
FX This study was supported by the Ministry of Science and Technology,
   Taiwan (MOST-108-2634-F-010-001) and Taipei Veterans General Hospital
   (107VACS-001). The authors thank the participants, who completed the
   time-consuming questionnaires and physical/cognitive tests so that we
   could better understand the effect of cognitive frailty. Dr. David Neil
   (PhD), of Full Universe Integrated Marketing, Taiwan, provided editorial
   assistance and his colleague Pei Chi Kuo assisted with manuscript
   preparation project management; Taipei Veterans General Hospital
   supported these contributions.
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NR 33
TC 26
Z9 30
U1 1
U2 39
PU SPRINGER FRANCE
PI PARIS
PA 22 RUE DE PALESTRO, PARIS, 75002, FRANCE
SN 1279-7707
EI 1760-4788
J9 J NUTR HEALTH AGING
JI J. Nutr. Health Aging
PD NOV
PY 2019
VL 23
IS 9
BP 904
EP 909
DI 10.1007/s12603-019-1235-5
PG 6
WC Geriatrics & Gerontology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology; Nutrition & Dietetics
GA JT5CT
UT WOS:000501008300019
PM 31641743
OA hybrid
DA 2025-06-11
ER

PT J
AU Rodriguez-Muñoz, A
   Motahari-Rad, H
   Martin-Chaves, L
   Benitez-Porres, J
   Rodriguez-Capitan, J
   Gonzalez-Jimenez, A
   Insenser, M
   Tinahones, FJ
   Murri, M
AF Rodriguez-Munoz, Alba
   Motahari-Rad, Hanieh
   Martin-Chaves, Laura
   Benitez-Porres, Javier
   Rodriguez-Capitan, Jorge
   Gonzalez-Jimenez, Andres
   Insenser, Maria
   Tinahones, Francisco J.
   Murri, Mora
TI 92A Systematic Review of Proteomics in Obesity: Unpacking the Molecular
   Puzzle
SO CURRENT OBESITY REPORTS
LA English
DT Review
DE Obesity; Proteomics; Metabolism; Personalized medicine
ID ENDOPLASMIC-RETICULUM STRESS; SUBCUTANEOUS ADIPOSE-TISSUE;
   LOW-DENSITY-LIPOPROTEIN; HEAT SHOCK PROTEIN-27; C-REACTIVE PROTEIN;
   SERUM-AMYLOID-P; METABOLIC SYNDROME; ATP SYNTHASE; DIABETES-MELLITUS;
   OXIDATIVE STRESS
AB Purpose of Review The present study aims to review the existing literature to identify pathophysiological proteins in obesity by conducting a systematic review of proteomics studies. Proteomics may reveal the mechanisms of obesity development and clarify the links between obesity and related diseases, improving our comprehension of obesity and its clinical implications.Recent Findings Most of the molecular events implicated in obesity development remain incomplete. Proteomics stands as a powerful tool for elucidating the intricate interactions among proteins in the context of obesity. This methodology has the potential to identify proteins involved in pathological processes and to evaluate changes in protein abundance during obesity development, contributing to the identification of early disease predisposition, monitoring the effectiveness of interventions and improving disease management overall. Despite many non-targeted proteomic studies exploring obesity, a comprehensive and up-to-date systematic review of the molecular events implicated in obesity development is lacking. The lack of such a review presents a significant challenge for researchers trying to interpret the existing literature.Summary This systematic review was conducted following the PRISMA guidelines and included sixteen human proteomic studies, each of which delineated proteins exhibiting significant alterations in obesity. A total of 41 proteins were reported to be altered in obesity by at least two or more studies. These proteins were involved in metabolic pathways, oxidative stress responses, inflammatory processes, protein folding, coagulation, as well as structure/cytoskeleton. Many of the identified proteomic biomarkers of obesity have also been reported to be dysregulated in obesity-related disease. Among them, seven proteins, which belong to metabolic pathways (aldehyde dehydrogenase and apolipoprotein A1), the chaperone family (albumin, heat shock protein beta 1, protein disulfide-isomerase A3) and oxidative stress and inflammation proteins (catalase and complement C3), could potentially serve as biomarkers for the progression of obesity and the development of comorbidities, contributing to personalized medicine in the field of obesity. Our systematic review in proteomics represents a substantial step forward in unravelling the complexities of protein alterations associated with obesity. It provides valuable insights into the pathophysiological mechanisms underlying obesity, thereby opening avenues for the discovery of potential biomarkers and the development of personalized medicine in obesity
C1 [Rodriguez-Munoz, Alba; Tinahones, Francisco J.; Murri, Mora] Hosp Univ Virgen Victoria, Endocrinol & Nutr UGC, Malaga, Spain.
   [Rodriguez-Munoz, Alba; Benitez-Porres, Javier; Tinahones, Francisco J.; Murri, Mora] Hosp Clin Virgen Victoria, Inst Invest Biomed Malaga & Plataforma Nanomed IBI, Plataforma BIONAND, Malaga, Spain.
   [Rodriguez-Munoz, Alba; Tinahones, Francisco J.; Murri, Mora] Inst Salud Carlos III, CIBER Fisiopatol Obes & Nutr CIBEROBN, Malaga, Spain.
   [Motahari-Rad, Hanieh; Murri, Mora] Tarbiat Modares Univ, Fac Biol Sci, Dept Mol Genet, Tehran, Iran.
   [Martin-Chaves, Laura; Rodriguez-Capitan, Jorge] Hosp Univ Virgen Victoria, Inst Invest Biomed Malaga & Plataforma Nanomed IBI, Plataforma BIONAND, Heart Area, Malaga, Spain.
   [Martin-Chaves, Laura; Tinahones, Francisco J.] Univ Malaga, Fac Med, Dept Dermatol & Med, E-29071 Malaga, Spain.
   [Benitez-Porres, Javier] Univ Malaga, Fac Med, Dept Human Physiol Phys Educ & Sports, Malaga, Spain.
   [Rodriguez-Capitan, Jorge] Inst Salud Carlos III, Biomed Res Network Ctr Cardiovasc Dis CIBERCV, Madrid 28029, Spain.
   [Gonzalez-Jimenez, Andres] ECAI Bioinformat Inst Biomed Res Malaga IBIMA, Malaga, Spain.
   [Insenser, Maria] Hosp Univ Ramon & Cajal, Dept Endocrinol & Nutr, Diabet Obes & Human Reprod Res Grp, Madrid, Spain.
   [Insenser, Maria] Univ Alcala, Madrid, Spain.
   [Insenser, Maria] Inst Ramon & Cajal Invest Sanitaria IRYCIS, Madrid, Spain.
   [Insenser, Maria] Ctr Invest Biomed Red Diabet & Enfermedades Metab, Madrid, Spain.
C3 Hospital Virgen de la Victoria; CIBER - Centro de Investigacion
   Biomedica en Red; CIBEROBN; Instituto de Salud Carlos III; Tarbiat
   Modares University; Hospital Virgen de la Victoria; Universidad de
   Malaga; Universidad de Malaga; Instituto de Salud Carlos III; Instituto
   de Investigacion Biomedica de Malaga y Plataforma en Nanomedicina
   (IBIMA); Hospital Universitario Ramon y Cajal; Universidad de Alcala;
   CIBER - Centro de Investigacion Biomedica en Red; CIBERDEM
RP Murri, M (corresponding author), Hosp Univ Virgen Victoria, Endocrinol & Nutr UGC, Malaga, Spain.; Murri, M (corresponding author), Hosp Clin Virgen Victoria, Inst Invest Biomed Malaga & Plataforma Nanomed IBI, Plataforma BIONAND, Malaga, Spain.; Murri, M (corresponding author), Inst Salud Carlos III, CIBER Fisiopatol Obes & Nutr CIBEROBN, Malaga, Spain.; Murri, M (corresponding author), Tarbiat Modares Univ, Fac Biol Sci, Dept Mol Genet, Tehran, Iran.; Insenser, M (corresponding author), Hosp Univ Ramon & Cajal, Dept Endocrinol & Nutr, Diabet Obes & Human Reprod Res Grp, Madrid, Spain.; Insenser, M (corresponding author), Univ Alcala, Madrid, Spain.; Insenser, M (corresponding author), Inst Ramon & Cajal Invest Sanitaria IRYCIS, Madrid, Spain.; Insenser, M (corresponding author), Ctr Invest Biomed Red Diabet & Enfermedades Metab, Madrid, Spain.
EM insensermaria@gmail.com; moramurri@gmail.com
RI Insenser, Mari­a/B-9674-2014; Bení­tez-Porres, Javier/R-5211-2019;
   Tinahones, Francisco/AAB-2882-2020; Motahari Rad, Hanieh/KYP-8104-2024;
   Rodríguez Capitán, Jorge/JRY-8513-2023; Gonzalez-Jimenez,
   Andres/E-5165-2018
OI Rodriguez- Munoz, Alba/0009-0005-8171-6223; Gonzalez-Jimenez,
   Andres/0000-0002-7059-1577; Motahari Rad, Hanieh/0000-0003-2386-2845
FU Consejeria de Salud y Consumo; Junta de Andalucia [RH-0095-2020];
   Instituto de Salud Carlos III [CPII22-00013]; Universidad de Malaga,
   Andalucia, Spain [UMA18-FEDERJA-285, CB06/03/0018, PI-0297-2018]
FX Consejeria de Salud y Consumo, Junta de Andalucia, RH-0095-2020,
   Instituto de Salud Carlos III, CPII22-00013, Universidad de Malaga,
   Andalucia, Spain, UMA18-FEDERJA-285, CB06/03/0018, PI-0297-2018.
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NR 241
TC 9
Z9 9
U1 4
U2 16
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 2162-4968
J9 CURR OBES REP
JI Curr. Obes. Rep.
PD SEP
PY 2024
VL 13
IS 3
BP 403
EP 438
DI 10.1007/s13679-024-00561-4
EA MAY 2024
PG 36
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA C0N6Z
UT WOS:001217495700001
PM 38703299
OA hybrid
DA 2025-06-11
ER

PT J
AU Manoel-Caetano, FS
   Xavier, DJ
   Evangelista, AF
   Takahashi, P
   Collares, CV
   Puthier, D
   Foss-Freitas, MC
   Foss, MC
   Donadi, EA
   Passos, GA
   Sakamoto-Hojo, ET
AF Manoel-Caetano, Fernanda S.
   Xavier, Danilo J.
   Evangelista, Adriane F.
   Takahashi, Paula
   Collares, Cristhianna V.
   Puthier, Denis
   Foss-Freitas, Maria C.
   Foss, Milton C.
   Donadi, Eduardo A.
   Passos, Geraldo A.
   Sakamoto-Hojo, Elza T.
TI Gene expression profiles displayed by peripheral blood mononuclear cells
   from patients with type 2 diabetes mellitus focusing on biological
   processes implicated on the pathogenesis of the disease
SO GENE
LA English
DT Article
DE Type 2 diabetes mellitus; Gene expression; Inflammatory response;
   Oxidative stress; DNA repair; Gene set analysis
ID NF-KAPPA-B; CORONARY-ARTERY-DISEASE; INSULIN-RESISTANCE;
   SKELETAL-MUSCLE; DNA-DAMAGE; METABOLIC SYNDROME; SOCS PROTEINS;
   IMMUNE-SYSTEM; TNF-ALPHA; OBESITY
AB Patients with type 2 diabetes mellitus (T2DM) exhibit insulin resistance associated with obesity and inflammatory response, besides an increased level of oxidative DNA damage as a consequence of the hyperglycemic condition and the generation of reactive oxygen species (ROS). In order to provide information on the mechanisms involved in the pathophysiology of T2DM, we analyzed the transcriptional expression patterns exhibited by peripheral blood mononuclear cells (PBMCs) from patients with T2DM compared to non-diabetic subjects, by investigating several biological processes: inflammatory and immune responses, responses to oxidative stress and hypoxia, fatty acid processing, and DNA repair. PBMCs were obtained from 20 T2DM patients and eight non-diabetic subjects. Total RNA was hybridized to Agilent whole human genome 4x44K one-color oligo-microarray. Microarray data were analyzed using the GeneSpring GX 11.0 software (Agilent). We used BRB-ArrayTools software (gene set analysis - GSA) to investigate significant gene sets and the Genomica tool to study a possible influence of clinical features on gene expression profiles. We showed that PBMCs from T2DM patients presented significant changes in gene expression, exhibiting 1320 differentially expressed genes compared to the control group. A great number of genes were involved in biological processes implicated in the pathogenesis of T2DM. Among the genes with high fold-change values, the up-regulated ones were associated with fatty acid metabolism and protection against lipid-induced oxidative stress, while the down-regulated ones were implicated in the suppression of pro-inflammatory cytokines production and DNA repair. Moreover, we identified two significant signaling pathways: adipocytokine, related to insulin resistance; and ceramide, related to oxidative stress and induction of apoptosis. In addition, expression profiles were not influenced by patient features, such as age, gender, obesity, pre/post-menopause age, neuropathy, glycemia, and HbA(1c) percentage. Hence, by studying expression profiles of PBMCs, we provided quantitative and qualitative differences and similarities between T2DM patients and non-diabetic individuals, contributing with new perspectives for a better understanding of the disease. (C) 2012 Elsevier B.V. All rights reserved.
C1 [Manoel-Caetano, Fernanda S.; Sakamoto-Hojo, Elza T.] Univ Sao Paulo, Dept Biol, Fac Philosophy Sci & Letters Ribeirao Preto, BR-14040901 Ribeirao Preto, SP, Brazil.
   [Manoel-Caetano, Fernanda S.; Xavier, Danilo J.; Evangelista, Adriane F.; Takahashi, Paula; Collares, Cristhianna V.; Passos, Geraldo A.; Sakamoto-Hojo, Elza T.] Univ Sao Paulo, Dept Genet, Fac Med Ribeirao Preto, BR-14040901 Ribeirao Preto, SP, Brazil.
   [Puthier, Denis] Aix Marseille Univ, INSERM, U928, TAGC,IFR137, Marseille, France.
   [Foss-Freitas, Maria C.; Foss, Milton C.; Donadi, Eduardo A.] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Clin Med, BR-14040901 Ribeirao Preto, SP, Brazil.
   [Passos, Geraldo A.] Univ Sao Paulo, Sch Dent Ribeirao Preto, Dept Morphol Stomatol & Physiol, BR-14040901 Ribeirao Preto, SP, Brazil.
C3 Universidade de Sao Paulo; Universidade de Sao Paulo; Aix-Marseille
   Universite; Institut National de la Sante et de la Recherche Medicale
   (Inserm); Universidade de Sao Paulo; Universidade de Sao Paulo
RP Sakamoto-Hojo, ET (corresponding author), Univ Sao Paulo, Dept Biol, Fac Philosophy Sci & Letters Ribeirao Preto, Av Bandeirantes 3900, BR-14040901 Ribeirao Preto, SP, Brazil.
EM etshojo@usp.br
RI Puthier, Denis/N-5018-2016; Foss-Freitas, Maria/AAV-5971-2021; Xavier,
   Danilo/G-4657-2012; Collares, Cristhianna/H-8521-2013; Passos,
   Geraldo/ABE-3251-2020; Evangelista, Adriane/F-4262-2014; Passos, Geraldo
   Aleixo/A-2899-2008; Foss-Freitas, Maria Cristina/F-1197-2013; donadi,
   eduardo/H-7080-2013; Sakamoto-Hojo, Elza Tiemi/C-3959-2012
OI Evangelista, Adriane/0000-0002-4731-2082; Passos, Geraldo
   Aleixo/0000-0002-4408-140X; Foss-Freitas, Maria
   Cristina/0000-0002-1350-1125; donadi, eduardo/0000-0002-9457-9601;
   Sakamoto-Hojo, Elza Tiemi/0000-0002-1383-3314; puthier,
   denis/0000-0002-7240-5280
FU Fundacao de Amparo a Pesquisa do Estado de Sao Paulo - FAPESP, Brazil
   [2010/00932-2, 2008/56594-8, 2010/12069-7, 2010/05622-1]; Conselho
   Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq, Brazil);
   Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES,
   Brazil); Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
   [08/56594-8, 10/12069-7] Funding Source: FAPESP
FX Gene set analysis was performed using BRB-ArrayTools developed by Dr.
   Richard Simon and BRB-ArrayTools Development Team. This study was
   supported by the Fundacao de Amparo a Pesquisa do Estado de Sao Paulo -
   FAPESP, Brazil (Grant numbers 2010/00932-2, 2008/56594-8, 2010/12069-7,
   and 2010/05622-1), the Conselho Nacional de Desenvolvimento Cientifico e
   Tecnologico (CNPq, Brazil), and the Coordenacao de Aperfeicoamento de
   Pessoal de Nivel Superior (CAPES, Brazil).
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NR 65
TC 48
Z9 52
U1 0
U2 31
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0378-1119
EI 1879-0038
J9 GENE
JI Gene
PD DEC 15
PY 2012
VL 511
IS 2
BP 151
EP 160
DI 10.1016/j.gene.2012.09.090
PG 10
WC Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Genetics & Heredity
GA 063TM
UT WOS:000313024700004
PM 23036710
DA 2025-06-11
ER

PT J
AU Lee, JH
   Joo, YB
   Han, M
   Kwon, SR
   Park, W
   Park, KS
   Yoon, BY
   Jung, KH
AF Lee, Joo-Hyun
   Joo, Young Bin
   Han, Minkyung
   Kwon, Seong Ryul
   Park, Won
   Park, Kyung-Su
   Yoon, Bo Young
   Jung, Kyong-Hee
TI Relationship between oxidative balance score and quality of life in
   patients with osteoarthritis Data from the Korea National Health and
   Nutrition Examination Survey (2014-2015)
SO MEDICINE
LA English
DT Article
DE osteoarthritis; oxidative stress; quality of life
ID SYMPTOMATIC KNEE OSTEOARTHRITIS; METABOLIC SYNDROME; STRESS;
   ANTIOXIDANT; INFLAMMATION; RISK; MORTALITY; CANCER
AB Osteoarthritis (OA) has a multifactorial etiology that includes oxidative stress. Oxidative balance score (OBS) is a well-known indicator of oxidative stress. However, the association between OBS and OA has not been assessed. Thus, this study aimed to investigate the associations of OBS with OA and quality of life (QOL) in patients with OA.
   By using data from the Korea National Health and Nutrition Examination Survey VI, patients previously diagnosed and/or treated by a physician were considered to have OA regardless of the affected joints. The control group was defined as participants without any form of chronic arthritis. OBS was calculated by combining 10 pro-oxidant and antioxidant factors through a baseline nutritional and lifestyle assessment. Higher OBS scores indicated a predominance of antioxidant exposure. Multivariable logistic regression was used to estimate the adjusted odds ratios (ORs) for OA, and the EuroQoL five-dimensional questionnaire (EQ5D) was used in patients with OA after adjusting for demographic factors and comorbidities.
   Among the 14,930 participants, 296 patients with OA, and 1,309 controls were included in the analysis. In the age-and sex-adjusted model, the OR of the total OBS for OA was significant. In the full model adjusted for age, sex, education, income, and comorbidities, the total OBS for OA was not significant. Only the non-dietary pro-oxidant OBS had a significant inverse association with OA. The patients with OA who had a high EQ5D score had a higher total OBS than those with a low EQ5D score. The OR of the total OBS for a high EQ5D score was 1.14 in the multivariable logistic regression model. As we analyzed the OBS as a categorical variable (reference = Q1), the ORs of the Q2, Q3, and Q4 (highest) total OBS were 1.43, 2.71, and 2.22, respectively.
   In the fully adjusted model, the total OBS was not associated with OA. However, a positive association was observed between the total OBS and QOL in the patients with OA, indicating that antioxidative status was associated with better QOL in patients with OA.
C1 [Lee, Joo-Hyun; Yoon, Bo Young] Inje Univ, Dept Rheumatol, Ilsan Paik Hosp, Goyang, South Korea.
   [Joo, Young Bin; Park, Kyung-Su] Catholic Univ Korea, St Vincents Hosp, Dept Rheumatol, Seoul, South Korea.
   [Han, Minkyung] Yonsei Univ, Coll Med, Dept Biomed Syst Informat, Seoul, South Korea.
   [Kwon, Seong Ryul; Park, Won; Jung, Kyong-Hee] Inha Univ, Coll Med, Dept Internal Med, Div Rheumatol, Incheon 22332, South Korea.
C3 Inje University; Catholic University of Korea; Yonsei University; Yonsei
   University Health System; Inha University
RP Jung, KH (corresponding author), Inha Univ, Coll Med, Dept Internal Med, Div Rheumatol, Incheon 22332, South Korea.
EM khjung@inha.ac.kr
RI KWON, SEONG-RYUL/GWN-2603-2022; Joo, Young-Bin/ABI-7631-2022
OI HAN, MINKYUNG/0000-0002-5011-5557
FU Inha University [58303-01]
FX This work was supported by a research grant from Inha University (grant
   no. 58303-01).
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NR 42
TC 19
Z9 19
U1 0
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD JUL
PY 2019
VL 98
IS 28
AR e16355
DI 10.1097/MD.0000000000016355
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA IQ4RU
UT WOS:000480738900041
PM 31305428
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Peix, A
   García, EJ
   Valiente, J
   Tornés, F
   Cabrera, LO
   Cabalé, B
   Carrillo, R
   Garcíia-Barreto, D
AF Peix, Amalia
   Garcia, Ernesto J.
   Valiente, Juan
   Tornes, Francisco
   Cabrera, Lazaro O.
   Cabale, Beatriz
   Carrillo, Regla
   Garcia-Barreto, David
TI Ischemia in women with angina and normal coronary angiograms
SO CORONARY ARTERY DISEASE
LA English
DT Article
DE microvascular angina; myocardial scintigraphy; myocardial stunning;
   ventricular function
ID LEFT-VENTRICULAR FUNCTION; MYOCARDIAL BLOOD-FLOW; CARDIAC SYNDROME-X;
   ENDOTHELIAL DYSFUNCTION; CHEST-PAIN; POSTSTRESS MEASUREMENTS; MEDIATED
   DILATION; PERFUSION SPECT; RISK-FACTORS; EXERCISE
AB Background Coronary artery disease is frequent in postmenopausal women. Myocardial ischemia has been induced with stress testing, and a relationship between endothelial dysfunction and perfusion defects has been reported. Objective To evaluate whether myocardial ischemia can be evidenced both by perfusion and function abnormalities using gated single-photon emission computed-tomography myocardial scintigraphy with technetium-labeled compounds in women with typical angina, normal coronary angiography, and endothelial dysfunction.
   Methods and Results Fifty-nine postmenopausal patients were studied. Each underwent technetium-99m methoxyisobutyl-isonitrile myocardial scintigraphy (protocol: exercise stress-rest), brachial artery endothelial function measured by ultrasonography, lipidogram, and 24-h ambulatory ECG recording (Holter). Twenty-one patients (group 1) showed perfusion defects in myocardial scintigraphy, whereas the other 38 patients (group 11) did not. Group I patients exhibited endothelial dysfunction more frequently (57 vs. 29%) than those of group II. Among group I patients, 12 showed a reversible perfusion defect that, in 75% of the cases, was associated with poststress left ventricular ejection fraction reduction greater than 5% and a regional hypokinesis. Nine patients had fixed defects, which in 56% of the cases were associated with poststress left ventricular ejection fraction reduction greater than 5%. Left ventricular ejection fraction poststress minus left ventricular ejection fraction at rest was -5.2% in group I patients versus - 1.8% in group II (P < 0.001). Three patients in group I showed evidence of ischemia by Holter compared with four in group II.
   Conclusion Stress-induced ischemia is associated with poststress left ventricular ejection fraction reduction in postmenopausal women with typical angina, normal coronary angiography, and a trend toward abnormal endothelial-mediated vasodilation.
C1 Inst Cardiol, Dept Nucl Med, Havana 10400, Cuba.
   Inst Cardiol, Havana, Cuba.
RP Peix, A (corresponding author), Inst Cardiol, Dept Nucl Med, 17 No 702, Havana 10400, Cuba.
EM peix@infomed.sld.eu
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NR 50
TC 11
Z9 13
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0954-6928
EI 1473-5830
J9 CORONARY ARTERY DIS
JI Coronary Artery Dis.
PD AUG
PY 2007
VL 18
IS 5
BP 361
EP 366
DI 10.1097/MCA.0b013e3281689a3f
PG 6
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 197BO
UT WOS:000248528500006
PM 17627185
DA 2025-06-11
ER

PT J
AU van Dijk, PR
   Abdulle, AE
   Bulthuis, MLC
   Perton, FG
   Connelly, MA
   van Goor, H
   Dullaart, RPF
AF van Dijk, Peter R.
   Abdulle, Amaal Eman
   Bulthuis, Marian L. C.
   Perton, Frank G.
   Connelly, Margery A.
   van Goor, Harry
   Dullaart, Robin P. F.
TI The Systemic Redox Status Is Maintained in Non-Smoking Type 2 Diabetic
   Subjects Without Cardiovascular Disease: Association with Elevated
   Triglycerides and Large VLDL
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Article
DE adiponectin; free thiols; nuclear magnetic resonance spectroscopy;
   phospholipid transfer protein activity; triglycerides; type 2 diabetes
   mellitus; large very low density lipoproteins
ID TRANSFER PROTEIN-ACTIVITY; CHOLESTERYL ESTER TRANSFER; DENSITY
   LIPOPROTEIN PRODUCTION; CYSTEINE-CONTAINING COMPOUNDS; APOLIPOPROTEIN-B
   SECRETION; INSULIN-RESISTANCE; METABOLIC SYNDROME; OXIDATIVE STRESS;
   LIPID-PEROXIDATION; PLASMA-GLUCOSE
AB Decreased circulating levels of free thiols (R-SH, sulfhydryl groups) reflect enhanced oxidative stress, which plays an important role in the pathogenesis of cardiometabolic diseases. Since hyperglycemia causes oxidative stress, we questioned whether plasma free thiols are altered in patients with type 2 diabetes mellitus (T2DM) without cardiovascular disease or renal function impairment. We also determined their relationship with elevated triglycerides and very low density lipoproteins (VLDL), a central feature of diabetic dyslipidemia. Fasting plasma free thiols (colorimetric method), lipoproteins, VLDL (nuclear magnetic resonance spectrometry), free fatty acids (FFA), phospholipid transfer protein (PLTP) activity and adiponectin were measured in 79 adult non-smoking T2DM subjects (HbA1c 51 +/- 8 mmol/mol, no use of insulin or lipid lowering drugs), and in 89 non-smoking subjects without T2DM. Plasma free thiols were univariately correlated with glucose (r = 0.196, p < 0.05), but were not decreased in T2DM subjects versus non-diabetic subjects (p = 0.31). Free thiols were higher in subjects with (663 +/- 84 mu mol/L) versus subjects without elevated triglycerides (619 +/- 91 mu mol/L; p = 0.002). Age- and sex-adjusted multivariable linear regression analysis demonstrated that plasma triglycerides were positively and independently associated with free thiols (beta = 0.215, p = 0.004), FFA (beta = 0.168, p = 0.029) and PLTP activity (beta = 0.228, p = 0.002), inversely with adiponectin (beta = -0.308, p < 0.001) but not with glucose (beta = 0.052, p = 0.51). Notably, the positive association of free thiols with (elevated) triglycerides appeared to be particularly evident in men. Additionally, large VLDL were independently associated with free thiols (beta = 0.188, p = 0.029). In conclusion, circulating free thiols are not decreased in this cohort of non-smoking and generally well-controlled T2DM subjects. Paradoxically, higher triglycerides and more large VLDL particles are likely associated with higher plasma levels of thiols, reflecting lower systemic oxidative stress.
C1 [van Dijk, Peter R.; Dullaart, Robin P. F.] Univ Groningen, Univ Med Ctr Groningen, Dept Endocrinol, NL-9700 RB Groningen, Netherlands.
   [Abdulle, Amaal Eman] Univ Groningen, Univ Med Ctr Groningen, Dept Internal Med, Div Vasc Med, NL-9700 RB Groningen, Netherlands.
   [Bulthuis, Marian L. C.; van Goor, Harry] Univ Groningen, Univ Med Ctr Groningen, Dept Pathol & Med Biol, Sect Pathol, NL-9700 RB Groningen, Netherlands.
   [Perton, Frank G.] Univ Groningen, Univ Med Ctr Groningen, Lab Ctr, NL-9700 RB Groningen, Netherlands.
   [Connelly, Margery A.] Lab Corp Amer Holdings LabCorp, Morrisville, NC 27560 USA.
C3 University of Groningen; University of Groningen; University of
   Groningen; University of Groningen
RP van Dijk, PR (corresponding author), Univ Groningen, Univ Med Ctr Groningen, Dept Endocrinol, NL-9700 RB Groningen, Netherlands.
EM p.r.van.dijk@umcg.nl; a.eman.abdulle@umcg.nl; m.l.c.bulthuis@umcg.nl;
   F.G.Perton@umcg.nl; connem5@labcorp.com; h.van.goor@umcg.nl;
   r.p.f.dullaart@umcg.nl
RI Connelly, Margery/IZP-5440-2023; van+Goor, Harry/AAS-7712-2020
OI van Dijk, Peter/0000-0002-9702-6551; Eman Abdulle,
   Amaal/0000-0003-3766-2238; van Goor, Harry/0000-0002-6670-1577;
   Dullaart, Robin/0000-0003-4520-1239
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NR 56
TC 9
Z9 9
U1 1
U2 3
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD JAN
PY 2020
VL 9
IS 1
AR 49
DI 10.3390/jcm9010049
PG 16
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA KO2OF
UT WOS:000515388400049
PM 31878321
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Sampathkumar, R
   Balasubramanyam, M
   Tara, C
   Rema, M
   Mohan, V
AF Sampathkumar, R
   Balasubramanyam, M
   Tara, C
   Rema, M
   Mohan, V
TI Association of hypoglutathionemia with reduced
   Na<SUP>+</SUP>/K<SUP>+</SUP> ATPase activity in type 2 diabetes and
   microangiopathy
SO MOLECULAR AND CELLULAR BIOCHEMISTRY
LA English
DT Article
DE advanced glycation end products (AGEs); diabetes; Na+/K+ ATPase;
   oxidative stress; reduced glutathione
ID URBAN-RURAL EPIDEMIOLOGY; RAT-BRAIN NA+,K+-ATPASE; OXIDATIVE STRESS;
   INSULIN-RESISTANCE; GLUTATHIONE DEPLETION; METABOLIC SYNDROME; PROTEIN
   DAMAGE; K+-ATPASE; GLYCATION; IDENTIFICATION
AB Objective: Although recent studies link altered cellular redox state to protein dysfunction in various disease-states, such associations are least studied in clinical diabetes. Therefore, this study assessed the levels of reduced glutathione (GSH) and Na+/K+ ATPase activities in type 2 diabetic patients with and without microangiopathy. Methods: The study group comprised of a total of 160 subjects, which included non-diabetic healthy controls ( n = 40) and type 2 diabetic patients without ( n = 60) and with microangiopathy ( n = 60), defined as presence of retinopathy with or without nephropathy. Erythrocyte Na+/ K+ ATPase activity and GSH levels were estimated spectrophotometrically and fluorometry was used to determine the plasma thiobarbituric acid reactive substances (TBARS) and serum advanced glycation end products (AGEs). Results: GSH levels in diabetic subjects without (4.8 +/- 0.15 mu mol/g Hb) and with microangiopathy (5.2 +/- 0.14 mu mol/g Hb) were significantly lower (p < 0.001) compared to control subjects (6.3 +/- 0.14 mu mol/g Hb). Erythrocyte Na+/ K+ ATPase activity was significantly reduced ( p < 0.001) in diabetes subjects with ( 272 +/- 7 nmol Pi/ mg protein/ h) and without microangiopathy (304 +/- 8) compared to control ( 374 +/- 6) subjects. TBARS were significantly higher ( p < 0.001) in diabetes subjects with (10.65 +/- 0.81 nM/ml) and without microangiopathy (9.90 +/- 0.5 nM/ml) compared to control subjects (5.18 +/- 0.18 nM/ml). Advanced glycation end product levels were also significantly ( p < 0.001) elevated in diabetic subjects with microangiopathy (8.2 +/- 1.8 AU) when compared to diabetes subjects without microangiopathy (7.0 +/- 2.0 AU) and control subjects (4.6 +/- 1.9 AU). On multivariate regression analysis, GSH levels showed a positive association with the Na+/ K+ ATPase activity and negative association with TBARS and AGE levels. Conclusion: Hypoglutathionemia and increased oxidative stress appears to be early biochemical aberrations in diabetes, and through protein alterations, oxidative stress and redox modifications may contribute to pathogenesis of diabetic microangiopathy.
C1 Madras Diabet Res Fdn, Dept Cell & Mol Biol, Madras 600086, Tamil Nadu, India.
   Dr Mohans MV Diabet Special Ctr, Madras, Tamil Nadu, India.
C3 Madras Diabetes Research Foundation
RP Madras Diabet Res Fdn, Dept Cell & Mol Biol, 6b,Conran Smith Rd, Madras 600086, Tamil Nadu, India.
EM drbalu@mvdsc.org
RI Viswanathan, Mohan/C-2321-2009; /B-7510-2009
OI Mohan, Viswanathan/0000-0001-5038-6210; /0000-0003-3952-4672; Rangasamy,
   Sampath/0000-0003-2151-9162
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NR 55
TC 23
Z9 24
U1 0
U2 1
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0300-8177
EI 1573-4919
J9 MOL CELL BIOCHEM
JI Mol. Cell. Biochem.
PD JAN
PY 2006
VL 282
IS 1-2
BP 169
EP 176
DI 10.1007/s11010-006-1740-9
PG 8
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA 989AN
UT WOS:000233645400019
PM 16317524
DA 2025-06-11
ER

PT J
AU Bashir, M
   Meddings, J
   Alshaikh, A
   Jung, D
   Le, K
   Amin, R
   Ratakonda, S
   Sharma, S
   Granja, I
   Satti, M
   Asplin, J
   Hassan, H
AF Bashir, Mohamed
   Meddings, Jon
   Alshaikh, Altayeb
   Jung, Daniel
   Le, Kim
   Amin, Ruhul
   Ratakonda, Sireesha
   Sharma, Sapna
   Granja, Ignacio
   Satti, Mustafa
   Asplin, John
   Hassan, Hatim
TI Enhanced gastrointestinal passive paracellular permeability contributes
   to the obesity-associated hyperoxaluria
SO AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
LA English
DT Article
DE gastrointestinal paracellular permeability; hyperoxaluria; inflammation;
   intestinal oxalate absorption; obesity; oxidative stress; tight junction
   proteins
ID EPITHELIAL BARRIER DYSFUNCTION; URINARY OXALATE EXCRETION; METABOLIC
   SYNDROME; OXIDATIVE STRESS; INTESTINAL PERMEABILITY; KIDNEY-STONES;
   TRANSPORT; MICE; ABSORPTION; RISK
AB Most kidney stones (KS) are composed of calcium oxalate and small increases in urine oxalate enhance the stone risk. Obesity is a risk factor for KS, and urinary oxalate excretion increases with increased body size. We previously established the obese ob/ob (ob) mice as a model (3.3-fold higher urine oxalate) to define the pathogenesis of obesity-associated hyperoxaluria (OAH) The purpose of this study was to test the hypothesis that the obesity-associated enhanced small intestinal paracellular permeability contributes to OAH by increasing passive paracellular intestinal oxalate absorption. ob Mice have significantly higher jejunal (1.6-fold) and ileal (1.4-fold) paracellular oxalate absorption ex vivo and significantly higher (5-fold) urine [C-13]oxalate following oral gavage with [C-13]oxalate, indicating increased intestinal oxalate absorption in vivo. The observation of higher oxalate absorption in vivo compared with ex vivo suggests the possibility of increased paracellular permeability along the entire gut. Indeed, ob mice have significantly higher fractions of the administered sucrose (1.7-fold), lactulose (4.4-fold). and sucralose (3.1-fold) excreted in the urine, reflecting increased gastric, small intestinal, and colonic paracellular permeability, respectively. The ob mice have significantly reduced gastrointestinal occludin, zonula occludens-1, and claudins-1. and -3 mRNA and total protein expression. Proinflammatory cytokines and oxidative stress, which are elevated in obesity, significantly enhanced paracellular intestinal oxalate absorption in vitro and ex vivo. We conclude that obese mice have significantly higher intestinal oxalate absorption and enhanced gastrointestinal paracellular permeability in vivo, which would likely contribute to the pathogenesis of OAH, since there is a transepithelial oxalate concentration gradient to drive paracellular intestinal oxalate absorption.
   NEW & NOTEWORTHY This study shows that the obese ob/ob mice have significantly increased gastrointestinal paracellular oxalate absorption and remarkably enhanced paracellular permeability along the entire gut in vivo, which are likely mediated by the obesity-associated increased systemic and intestinal inflammation and oxidative stress. A transepithelial oxalate concentration gradient driving gastrointestinal paracellular oxalate absorption exists, and therefore. our novel findings likely contribute to the hyperoxaluria observed in the ob/ob mice and hence to the pathogenesis of obesity-associated hyperoxaluria.
C1 [Bashir, Mohamed; Alshaikh, Altayeb; Jung, Daniel; Amin, Ruhul; Ratakonda, Sireesha; Sharma, Sapna; Satti, Mustafa; Hassan, Hatim] Univ Chicago, Dept Med, 5841 S Maryland Ave, Chicago, IL 60637 USA.
   [Meddings, Jon; Le, Kim] Univ Calgary, Dept Surg, Calgary, AB, Canada.
   [Granja, Ignacio; Asplin, John] Litholink Corp, Lab Corp Amer Holdings, Chicago, IL USA.
C3 University of Chicago; University of Calgary; Litholink
RP Hassan, H (corresponding author), Univ Chicago, Dept Med, Sect Nephrol, 5841 S Maryland Ave,MC5100, Chicago, IL 60637 USA.
EM hhassan@medicine.bsd.uchicago.edu
RI Jung, Daniel/HKF-2653-2023; Amin, Md. Ruhul/KRP-9631-2024
OI Amin, Md Ruhul/0000-0002-5795-074X; Hassan, Hatim/0000-0003-4744-8665;
   Sharma, Sapna/0000-0002-0855-5735
FU National Institute of Diabetes and Digestive and Kidney Diseases
   [R01-DK-101643, P30-DK-42086]
FX This work was supported by National Institute of Diabetes and Digestive
   and Kidney Diseases Grants R01-DK-101643 (to H. A. Hassan) and
   P30-DK-42086 (the Digestive Disease Research Center of the University of
   Chicago).
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NR 68
TC 18
Z9 19
U1 1
U2 8
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0193-1857
EI 1522-1547
J9 AM J PHYSIOL-GASTR L
JI Am. J. Physiol.-Gastroint. Liver Physiol.
PD JAN
PY 2019
VL 316
IS 1
BP G1
EP G14
DI 10.1152/ajpgi.00266.2018
PG 14
WC Gastroenterology & Hepatology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Physiology
GA HE7AD
UT WOS:000453573300001
PM 30307745
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Barillari, G
   Fabbro, E
   Pasca, S
   Bigotto, E
AF Barillari, Giovanni
   Fabbro, Elisabetta
   Pasca, Samantha
   Bigotto, Enrico
TI Coagulation and oxidative stress plasmatic levels in a type 2 diabetes
   population
SO BLOOD COAGULATION & FIBRINOLYSIS
LA English
DT Article
DE cardiovascular risk; coagulation factors; metabolic syndrome; oxidative
   stress; thrombosis; type 2 diabetes mellitus
ID ENDOTHELIAL DYSFUNCTION; OBESITY; HEMOSTASIS; MELLITUS; PAI-1; RISK
AB Type 2 diabetes mellitus (DM2) is a metabolic disorder characterized by relative insulin deficiency, insulin resistance and hyperglycemia. DM2 improperly managed can cause severe complications such as renal failure, blindness or arterial disease. In addition to serious complications due to DM2, in the past 20 years, several studies have demonstrated the association between DM2, insulin resistance and prothrombotic risk. In our study, we wanted to evaluate the correlation between coagulation factor levels, oxidative plasmatic levels and DM2. We considered 20 DM2 patients (65% women and 35% men), 40-65 years of age, who had a BMI between 25 and 40 kg/m(2) and followed a diet with or without oral antidiabetic treatment and 20 controls, blood donors, 15 men (75%) and five women (25%), who had a BMI between 25 and 40 kg/m(2) and their age was between 40 and 65 years. Plasmatic levels of oxidative stress markers (tumor necrosis factor-alpha, nitrotyrosine, oxidized low-density lipoprotein) and coagulation markers (factors VII, VIII, IX, XI, XII, antithrombin III and fibrinogen) of both populations were analyzed following statistic criteria. The analyzed data of this study related to oxidative stress and coagulation factors proved that the differences observed between diabetic patients and controls were not statistically significant (P<0.05) for tumor necrosis factor-alpha, nitrotyrosine, oxidized low-density lipoprotein, factor VII and factor XI; conversely for factor Vill, factor IX, factor XII, antithrombin III and fibrinogen, the results gave a difference statistically significant (P<0.01). In patients with DM2, factor Vill increased from 79 to 103%, factor IX from 88 to 103%, factor XII from 87 to 105% and finally, antithrombin III from 81 to 103%. Different results between literature and our study could be due to fact that the patients considered were in the early stage of diabetes when endothelial damage is absent and vascular complications are not clinically expressed. In this study, it is still shown that DM2 is a multifactor disease and its physiopathologic mechanisms are not completely known today. Blood Coagui Fibrinolysis 20:290-296 (C) 2009 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
C1 [Barillari, Giovanni; Pasca, Samantha; Bigotto, Enrico] Ctr Hemorrhag & Thrombot Dis, Dept Transfus Med, Udine, Italy.
   [Fabbro, Elisabetta] Gen Univ Hosp Udine, Internal Med Clin, Udine, Italy.
C3 University of Udine; University Hospital of Udine
RP Pasca, S (corresponding author), Ctr Hemorrhag & Thrombot Dis, Dept Transfus Med, Udine, Italy.
EM sampasca@alice.it
RI Pasca, Samantha/AAM-5310-2020
OI Pasca, Samantha/0000-0002-0954-013X; Barillari,
   Giovanni/0000-0002-0706-8839
CR Alessi MC, 2008, THROMB HAEMOSTASIS, V99, P995, DOI 10.1160/TH07-11-0682
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NR 26
TC 19
Z9 26
U1 0
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0957-5235
EI 1473-5733
J9 BLOOD COAGUL FIBRIN
JI Blood Coagul. Fibrinolysis
PD JUN
PY 2009
VL 20
IS 4
BP 290
EP 296
DI 10.1097/MBC.0b013e328329e49b
PG 7
WC Hematology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Hematology
GA 446VB
UT WOS:000266148400012
PM 19318924
DA 2025-06-11
ER

PT J
AU Ashor, AW
   Chowdhury, S
   Oggioni, C
   Qadir, O
   Brandt, K
   Ishaq, A
   Mathers, JC
   Saretzki, G
   Siervo, M
AF Ashor, Ammar W.
   Chowdhury, Shakir
   Oggioni, Clio
   Qadir, Othman
   Brandt, Kirsten
   Ishaq, Abbas
   Mathers, John C.
   Saretzki, Gabriele
   Siervo, Mario
TI Inorganic Nitrate Supplementation in Young and Old Obese Adults Does Not
   Affect Acute Glucose and Insulin Responses but Lowers Oxidative Stress
SO JOURNAL OF NUTRITION
LA English
DT Article
DE nitric oxide; aging; obesity; endothelial function; dietary nitrate;
   reactive oxygen species; inflammation
ID REDUCES BLOOD-PRESSURE; DIETARY NITRATE; NITRIC-OXIDE; ENDOTHELIAL
   FUNCTION; BEETROOT JUICE; SODIUM-NITRITE; METABOLIC SYNDROME; NADPH
   OXIDASE; DOUBLE-BLIND; IMPROVES
AB Background: Aging and obesity are associated with raised oxidative stress and a reduction of nitric oxide (NO) bioavailability, with subsequent decline in insulin sensitivity and endothelial function. Inorganic nitrate is converted into NO via a 2-step reduction process and may be an effective nutritional intervention to modify vascular and metabolic functions.
   Objectives: This study tested whether inorganic nitrate supplementation improved glucose disposal and attenuated the acute effects of hyperglycemia on oxidative stress, inflammation, and vascular function in young and old obese participants.
   Methods: Ten young (aged 18-44 y) and 10 old (aged 55-70 y) obese participants consumed 75 g glucose followed by either potassium nitrate (7 mg/kg body weight) or potassium chloride (placebo) in a randomized, double-blind crossover design. Resting blood pressure (BP), endothelial function, and blood biomarkers were measured for 3 h postintervention. Biomarkers included plasma nitrate/nitrite (NOx), glucose, insulin, cyclic GMP, interleukin 6, 3-nitrotyrosine, E- and P-selectins, intercellular adhesion molecule 3 (ICAM-3), and thrombomodulin, as well as superoxide in freshly isolated peripheral blood mononuclear cells (PBMCs).
   Results: Inorganic nitrate supplementation did not affect plasma glucose (P =0.18) or insulin (P =0.26) responses. The increase in plasma NOx concentrations 3 h after the administration of inorganic nitrate was significantly higher in young than in old participants (234% increase compared with 149% increase, respectively, P < 0.001). Plasma 3-nitrotyrosine concentrations declined significantly after inorganic nitrate supplementation compared with placebo (3 h postdose, 46% decrease compared with 27% increase, respectively, P=0.04), and a similar nonsignificant trend was observed for superoxide concentrations (3 h postdose, 16% decrease compared with 23% increase, respectively, P=0.06). Plasma cyclic GMP, ICAM-3, and thrombomodulin concentrations differed between young and old participants (P < 0.01). Inorganic nitrate supplementation did not improve BP or endothelial function.
   Conclusions: Oral supplementation with inorganic nitrate did not improve glucose and insulin responses but reduced oxidative stress in old individuals during acute hyperglycemia. This trial was registered at www.controlled-trials.com as ISRCTN42776917.
C1 [Ashor, Ammar W.; Chowdhury, Shakir; Oggioni, Clio; Mathers, John C.; Siervo, Mario] Newcastle Univ, Inst Cellular Med, Human Nutr Res Ctr, Newcastle Upon Tyne, Tyne & Wear, England.
   [Qadir, Othman; Brandt, Kirsten] Newcastle Univ, Sch Agr Food & Rural Dev, Human Nutr Res Ctr, Newcastle Upon Tyne, Tyne & Wear, England.
   [Ishaq, Abbas; Saretzki, Gabriele] Newcastle Univ, Inst Cell & Mol Biosci, Newcastle Upon Tyne, Tyne & Wear, England.
   [Mathers, John C.] Newcastle Univ, Res Councils UK Ctr Ageing & Vital, Newcastle Upon Tyne, Tyne & Wear, England.
   [Ashor, Ammar W.; Brandt, Kirsten; Ishaq, Abbas; Mathers, John C.; Saretzki, Gabriele; Siervo, Mario] Newcastle Univ, Inst Ageing, Newcastle Upon Tyne, Tyne & Wear, England.
   [Ashor, Ammar W.] Univ Al Mustansiriyah, Coll Med, Baghdad, Iraq.
C3 Newcastle University - UK; Newcastle University - UK; Newcastle
   University - UK; Newcastle University - UK; Newcastle University - UK;
   Mustansiriya University
RP Siervo, M (corresponding author), Newcastle Univ, Inst Cellular Med, Human Nutr Res Ctr, Newcastle Upon Tyne, Tyne & Wear, England.; Siervo, M (corresponding author), Newcastle Univ, Inst Ageing, Newcastle Upon Tyne, Tyne & Wear, England.
EM mariosiervo@ncl.ac.uk
RI Mathers, Jonathan/ABE-1164-2021; Saretzki, Gabriele/I-7175-2019; Siervo,
   Mario/AAB-9302-2019; Qadir, Othman/I-4841-2016; Brandt,
   Kirsten/B-4707-2008; Ashor, Ammar Waham/A-9094-2013
OI Brandt, Kirsten/0000-0002-7001-2459; Saretzki,
   Gabriele/0000-0003-2100-8223; Ashor, Ammar Waham/0000-0002-0826-5471;
   Ishaq, Abbas/0000-0001-6344-466X; Siervo, Mario/0000-0001-5515-0944
FU Newcastle University Faculty of Medical Sciences Wellcome Trust
   Institutional Strategic Support Fund Project; MRC [MC_UP_1005/2,
   MR/N007921/1, MR/K006312/1] Funding Source: UKRI
FX This study was funded by the Newcastle University Faculty of Medical
   Sciences Wellcome Trust Institutional Strategic Support Fund Project.
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NR 57
TC 40
Z9 40
U1 0
U2 13
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0022-3166
EI 1541-6100
J9 J NUTR
JI J. Nutr.
PD NOV
PY 2016
VL 146
IS 11
BP 2224
EP 2232
DI 10.3945/jn.116.237529
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA EB3XD
UT WOS:000387301500008
PM 27733522
OA Bronze
DA 2025-06-11
ER

PT J
AU Liu, XF
   Yu, JQ
   Dalan, R
   Liu, AQ
   Luo, KQ
AF Liu, X. F.
   Yu, J. Q.
   Dalan, R.
   Liu, A. Q.
   Luo, K. Q.
TI Biological factors in plasma from diabetes mellitus patients enhance
   hyperglycaemia and pulsatile shear stress-induced endothelial cell
   apoptosis
SO INTEGRATIVE BIOLOGY
LA English
DT Article
ID CORONARY-ARTERY-DISEASE; APOLIPOPROTEIN-C-III; ENERGY-TRANSFER FRET;
   PROTEIN-KINASE-C; BLOOD-FLOW; VASCULAR ENDOTHELIUM; METABOLIC SYNDROME;
   OXIDATIVE STRESS; ACTIVATION; ATHEROSCLEROSIS
AB People suffering from Diabetes Mellitus (DM) are prone to an array of vascular complications leading to end organ damage. The hallmark of these vascular complications is endothelium dysfunction, which is caused by endothelial cell (EC) apoptosis. Although the endothelial cell (EC) dysfunction induced by hyperglycaemia and fluid shear stress has been studied, the effects of biological factors in the blood of DM patients on EC integrity have not been reported in the in vitro models that mimic the physiological pulsatile nature of the vascular system. This study reports the development of a hemodynamic lab-on-achip system to investigate this issue. The pulsatile flow was applied to a monolayer of endothelial cells expressing a fluorescence resonance energy transfer (FRET)-based biosensor that changes colour from green to blue in response to caspase-3 activation during apoptosis. Plasma samples from healthy volunteers and DM patients were compared to identify biological factors that are critical to endothelial disruption. Three types of microchannels were designed to simulate the blood vessels under healthy and partially blocked pathological conditions. The results showed that EC apoptosis rates increased with increasing glucose concentration and levels of shear stress. The rates of apoptosis further increased by a factor of 1.4-2.3 for hyperglycaemic plasma under all dynamic conditions. Under static conditions, little difference was detected in the rate of EC apoptosis between experiments using plasma from DM patients and glucose medium, suggesting that the effects of hyperglycaemia and biological factors on the induction of EC apoptosis are all shear flow-dependent. A proteomics study was then conducted to identify biological factors, demonstrating that the levels of eight proteins, including haptoglobin and clusterin, were significantly down-regulated, while six proteins, including apolipoprotein C-III, were significantly upregulated in the plasma of DM patients compared to healthy volunteers. This hemodynamic lab-on-a-chip system can serve as a high throughput platform to assess the risk of vascular complications of DM patients and to determine the effects of therapeutics or other interventions on EC apoptosis.
C1 [Liu, X. F.; Liu, A. Q.; Luo, K. Q.] Nanyang Technol Univ, Sch Chem & Biomed Engn, Singapore 637457, Singapore.
   [Yu, J. Q.] Nanyang Technol Univ, Sch Elect & Elect Engn, Singapore 639798, Singapore.
   [Dalan, R.] Tan Tock Seng Hosp, Dept Endocrinol, Singapore 308433, Singapore.
   [Dalan, R.] Natl Univ Singapore, Yong Loo Lin Sch Med, Singapore 119228, Singapore.
   [Dalan, R.] Duke NUS, Grad Sch Med, Singapore 169547, Singapore.
C3 Nanyang Technological University; Nanyang Technological University; Tan
   Tock Seng Hospital; National University of Singapore; National
   University of Singapore
RP Luo, KQ (corresponding author), Nanyang Technol Univ, Sch Chem & Biomed Engn, 70 Nanyang Dr, Singapore 637457, Singapore.
EM kluo@ntu.edu.sg
RI Liu, Aiqun/A-5066-2011; Luo, Kathy Qian/G-6201-2010; Dalan,
   Rinkoo/HNJ-1349-2023; Dalan, Rinkoo/C-1099-2019
OI Liu, Ai Qun/0000-0002-0126-5778; Dalan, Rinkoo/0000-0001-9769-2696; Luo,
   Kathy Qian/0000-0001-7454-9547
FU Singapore National Research Foundation NRF-CRP8-2011-05 [M4092018.0S4];
   Ministry of Education of Singapore AcRF Tier 1 [M4010891.120];
   Environmental and Water Industry Development Council of Singapore
   [1102-IRIS-05-02]
FX This work was supported in part by the Singapore National Research
   Foundation NRF-CRP8-2011-05 (Grant No. M4092018.0S4), the Ministry of
   Education of Singapore AcRF Tier 1 (Grant No. M4010891.120), and the
   Environmental and Water Industry Development Council of Singapore (Grant
   No. 1102-IRIS-05-02).
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NR 42
TC 22
Z9 25
U1 0
U2 21
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 1757-9694
EI 1757-9708
J9 INTEGR BIOL-UK
JI Integr. Biol.
PY 2014
VL 6
IS 5
BP 511
EP 522
DI 10.1039/c3ib40265g
PG 12
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA AF9CL
UT WOS:000335012700002
PM 24643402
DA 2025-06-11
ER

PT J
AU Jablonski, KL
   Seals, DR
   Eskurza, I
   Monahan, KD
   Donato, AJ
AF Jablonski, Kristen L.
   Seals, Douglas R.
   Eskurza, Iratxe
   Monahan, Kevin D.
   Donato, Anthony J.
TI High-dose ascorbic acid infusion abolishes chronic vasoconstriction and
   restores resting leg blood flow in healthy older men
SO JOURNAL OF APPLIED PHYSIOLOGY
LA English
DT Article
DE aging; vitamin C; arterial function; vascular conductance
ID ENDOTHELIUM-DEPENDENT DILATATION; ELASTIC ARTERY COMPLIANCE; AGE-RELATED
   DECREASES; OXIDATIVE STRESS; NITRIC-OXIDE; VASCULAR CONDUCTANCE;
   SKELETAL-MUSCLE; METABOLIC SYNDROME; CARDIAC-OUTPUT; RISK-FACTORS
AB Resting whole leg blood flow and vascular conductance decrease linearly with advancing age in healthy adult men. The potential role of age- related increases in oxidative stress in these changes is unknown. Resting leg blood flow during saline and ascorbic acid infusion was studied in 10 young ( 25 +/- 1 yr) and 11 older ( 63 +/- 2 yr) healthy normotensive men. Plasma oxidized LDL, a marker of oxidative stress, was greater in the older men ( P < 0.05). Absolute resting femoral artery blood flow at baseline ( iv saline control infusion) was 25% lower in the older men ( 238 +/- 25 vs. 316 +/- 38 ml/ min; P < 0.05), and it was inversely related to plasma oxidized LDL (r =-0.56, P < 0.01) in all subjects. Infusion of supraphysiological concentrations of ascorbic acid increased femoral artery blood flow by 37% in the older men ( to 327 +/- 52 ml/ min; P < 0.05), but not in the young men ( 352 +/- 41 ml/ min; P = 0.28), thus abolishing group differences ( P = 0.72). Mean arterial blood pressure was greater in the older men at baseline ( 86 +/- 4 vs. 78 +/- 2 mmHg; P < 0.05), but it was unaffected by ascorbic acid infusion ( P >= 0.70). As a result, the lower baseline femoral artery blood flow in the older men was mediated solely by a 32% lower femoral artery vascular conductance ( P < 0.05). Baseline femoral vascular conductance also was inversely related to plasma oxidized LDL (r =- 0.65, P < 0.01). Ascorbic acid increased femoral vascular conductance by 36% in the older men ( P < 0.05) but not in the young men ( P = 0.31). In conclusion, ascorbic acid infused at concentrations known to scavenge reactive oxygen species restores resting femoral artery blood flow in healthy older adult men by increasing vascular conductance. These results support the hypothesis that oxidative stress plays a major role in the reduced resting whole leg blood flow and increased leg vasoconstriction observed with aging in men.
C1 Univ Colorado, Dept Integrat Physiol, Boulder, CO 80309 USA.
C3 University of Colorado System; University of Colorado Boulder
RP Donato, AJ (corresponding author), Univ Colorado, Dept Integrat Physiol, Boulder, CO 80309 USA.
EM tony.donato@colorado.edu
RI Nowak, Kristen/D-4391-2012
OI Nowak, Kristen/0000-0001-9364-3256
FU NCRR NIH HHS [RR-00051] Funding Source: Medline; NIA NIH HHS [R01
   AG006537, AG-006537, AG-029337, R01 AG022241, AG-13038, AG-22241, K01
   AG029337] Funding Source: Medline
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NR 47
TC 70
Z9 80
U1 0
U2 8
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 8750-7587
EI 1522-1601
J9 J APPL PHYSIOL
JI J. Appl. Physiol.
PD NOV
PY 2007
VL 103
IS 5
BP 1715
EP 1721
DI 10.1152/japplphysiol.00533.2007
PG 7
WC Physiology; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology; Sport Sciences
GA 224WZ
UT WOS:000250480400031
PM 17965239
DA 2025-06-11
ER

PT J
AU Ghazizadeh, H
   Mirinezhad, MR
   Seyedi, SMR
   Sadabadi, F
   Ahmadnezhad, M
   Jaberi, N
   Pasdar, A
   Ferns, GA
   Esmaily, H
   Ghayour-Mobarhan, M
AF Ghazizadeh, Hamideh
   Mirinezhad, Mohammad Reza
   Seyedi, Seyed Mohammad Reza
   Sadabadi, Fatemeh
   Ahmadnezhad, Mahsa
   Jaberi, Naghme
   Pasdar, Alireza
   Ferns, Gordon A.
   Esmaily, Habibollah
   Ghayour-Mobarhan, Majid
TI Prognostic Factors Associating with Pro-oxidant-antioxidant Balance;
   Neutrophils to Lymphocytes Ratio, Vitamin D, Heat Shock Protein 27, and
   Red Cell Distribution Width
SO ARCHIVES OF MEDICAL RESEARCH
LA English
DT Article
DE Red blood cell distribution width (RDW); Pro-oxidant-antioxidant balance
   (PAB); Neutrophil to lymphocyte ratio (NLR); Vitamin D; anti-hsp27
ID NO-REFLOW PHENOMENON; OXIDATIVE STRESS; NEUTROPHIL/LYMPHOCYTE RATIO;
   MYOCARDIAL-INFARCTION; METABOLIC SYNDROME; ANTIBODY-TITERS; RISK;
   MORTALITY; DISEASE; PATHOGENESIS
AB Background. Several chronic diseases are mediated by oxidative stress. Oxidative stress affects cell morphology and function and is associated with alterations in the serum protein component. In the current study, we analyzed four individual prognostic factors associating with serum Pro-Oxidant-Antioxidant Balance (PAB): neutrophil to lymphocyte ratio (NLR), Vitamin D, anti-heat shock protein 27 (anti-hsp27) antibody titer, and red blood cell distribution width (RDW) to evaluate them as the potential prognostic markers. In the current study, we attempted to investigate the relationship between serum PAB, RDW, NLR, serum vitamin D and anti-hsp27 concentration.
   Methods. A total of 852 participants (438 males and 414 females) aged 47.64 +/- 7.77 years were recruited in a cross-sectional study based on the Mashhad stroke and heart atherosclerotic disorders (MASHAD) cohort study data. Hematological parameters, and vitamin D, PAB and anti-hsp27 antibody titers were measured using the Sysmex auto analyzer system and enzyme-linked immune sorbent assay (ELISA), respectively.
   Results. The results showed a significant correlation between Vitamin D and anti-hsp27 antibody titers (r = -0.13 and p <0.001) as well as between RDW and serum PAB (r = 0.120 and p < 0.001). Moreover, we found that serum PAB was positively associated with serum anti hsp27 antibody titers. The results showed increasing 1 unit of serum vitamin D can cause 3% decreases in anti hsp 27 values (OR = 0.97; CI 95% (0.96-0.99); p = 0.004). While this association was not significant for RDW, NLR and PAB (p > 0.05) we found a significant association between serum PAB and serum anti hsp-27 antibody titers. Subjects with PAB levels 36.31-82.63 had a higher risk (1.83 fold) of having an increased anti-hsp27 antibody titers in comparison to the reference group (PAB level <36.31) (OR = 1.83 (95% CI = 1.33-2.52), p <0.001).
   Conclusion. The present study shows that serum vitamin D can be associated with reduction in inflammatory status probably by decreasing levels of serum anti-hsp27 antibody titers, reduction in oxidative stress and therefore may reduce the risk of cardiovascular diseases. Anti-hsp27 antibody titers are associated with oxidative stress through the serum PAB, therefore these factors may be of prognostic values in detecting oxidative stress and risk of atherosclerosis. The evaluation of these factors in a larger population may help further confirm these findings. (C) 2020 IMSS. Published by Elsevier Inc.
C1 [Ghazizadeh, Hamideh; Sadabadi, Fatemeh; Ahmadnezhad, Mahsa; Pasdar, Alireza; Ghayour-Mobarhan, Majid] Mashhad Univ Med Sci, Metab Syndrome Res Ctr, Sch Med, Mashhad 9919991766, Razavi Khorasan, Iran.
   [Ghazizadeh, Hamideh] Mashhad Univ Med Sci, Sch Med, Dept Nutr, Student Res Comm, Mashhad, Razavi Khorasan, Iran.
   [Ghazizadeh, Hamideh; Ghayour-Mobarhan, Majid] Mashhad Univ Med Sci, Fac Med, Int UNESCO Ctr Hlth Related Basic Sci & Human Nut, Dept Nutr, Mashhad, Razavi Khorasan, Iran.
   [Mirinezhad, Mohammad Reza] Mashhad Univ Med Sci, Fac Med, Dept Med Genet, Mashhad, Razavi Khorasan, Iran.
   [Seyedi, Seyed Mohammad Reza] Ferdowsi Univ Mashhad, Fac Sci, Dept Biol, Mashhad, Razavi Khorasan, Iran.
   [Jaberi, Naghme] Mashhad Univ Med Sci, Sch Med, Dept Med Biochem, Mashhad, Razavi Khorasan, Iran.
   [Pasdar, Alireza] Univ Aberdeen, Med Sch, Div Appl Med, Aberdeen, Scotland.
   [Ferns, Gordon A.] Brighton & Sussex Med Sch, Div Med Educ, Brighton, Sussex, England.
   [Esmaily, Habibollah] Mashhad Univ Med Sci, Sch Hlth, Dept Biostat & Epidemiol, Mashhad, Razavi Khorasan, Iran.
C3 Mashhad University of Medical Sciences; Mashhad University of Medical
   Sciences; Mashhad University of Medical Sciences; Mashhad University of
   Medical Sciences; Ferdowsi University Mashhad; Mashhad University of
   Medical Sciences; University of Aberdeen; University of Sussex;
   University of Brighton; Mashhad University of Medical Sciences
RP Ghayour-Mobarhan, M (corresponding author), Mashhad Univ Med Sci, Metab Syndrome Res Ctr, Sch Med, Mashhad 9919991766, Razavi Khorasan, Iran.
EM ghayourm@mums.ac.ir
RI Ghazizadeh, Hamideh/ABE-8941-2020; Ghayour-Mobarhan, Majid/AAY-5963-2020
OI Pasdar, Alireza/0000-0002-7864-9729
FU Mashhad University of Medical Sciences Research council
   [IR.MUMS.REC.1386.250]
FX We would like to thank Mashhad University of Medical Sciences Research
   council for their financial support. The study was approved by the
   Ethics Committee of Mashhad University of Medical Sciences (Ethics
   number: IR.MUMS.REC.1386.250).
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NR 55
TC 18
Z9 19
U1 0
U2 4
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0188-4409
EI 1873-5487
J9 ARCH MED RES
JI Arch. Med. Res.
PD APR
PY 2020
VL 51
IS 3
BP 261
EP 267
DI 10.1016/j.arcmed.2020.02.006
PG 7
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA LS1GC
UT WOS:000536139200009
PM 32111498
DA 2025-06-11
ER

PT J
AU Paltoglou, G
   Schoina, M
   Valsamakis, G
   Salakos, N
   Avloniti, A
   Chatzinikolaou, A
   Margeli, A
   Skevaki, C
   Papagianni, M
   Kanaka-Gantenbein, C
   Papassotiriou, I
   Chrousos, GP
   Fatouros, IG
   Mastorakos, G
AF Paltoglou, George
   Schoina, Maria
   Valsamakis, George
   Salakos, Nicolaos
   Avloniti, Alexandra
   Chatzinikolaou, Athanasios
   Margeli, Alexandra
   Skevaki, Chrysanthi
   Papagianni, Maria
   Kanaka-Gantenbein, Christina
   Papassotiriou, Ioannis
   Chrousos, George P.
   Fatouros, Ioannis G.
   Mastorakos, George
TI Interrelations among the adipocytokines leptin and adiponectin,
   oxidative stress and aseptic inflammation markers in pre- and
   early-pubertal normal-weight and obese boys
SO ENDOCRINE
LA English
DT Article
DE Adipokines/Adipocytokines; Aerobic exercise; Children; Inflammation;
   Obese; Oxidative stress; Puberty
ID C-REACTIVE PROTEIN; METABOLIC SYNDROME; PROINFLAMMATORY CYTOKINES;
   POSITIVE ASSOCIATION; PREPUBERTAL CHILDREN; LUTEINIZING-HORMONE; 3T3-L1
   ADIPOCYTES; ADIPOSE-TISSUE; RISK-FACTORS; EXERCISE
AB Presumed interrelationships among deleterious aspects of adipose tissue metabolism, inflammation, and cellular oxidative stress could be influenced by pubertal hormonal changes. They were investigated in pre- and early pubertal normal-weight and obese boys before and after an exercise bout employed as an energy demanding stimulator.
   Cross-sectional study. Seventy-six healthy pre- (mean +/- SD, 10.6 +/- 0.2 years old, 28 normal-weight, and 11 obese) and early-(11.4 +/- 0.2 years old, 25 normal-weight, and 12 obese) pubertal boys, were blood-sampled before and after a bout of exercise at 70% VO2 max. Leptin, adiponectin, markers of inflammation (high-sensitivity C-reactive protein, high sensitivity IL-6), pro- (thiobarbitouric acid reactive substances, protein carbonyls) and anti- (glutathione, oxidized glutathione, glutathione peroxidase, catalase, total antioxidant capacity) oxidation were measured.
   Baseline and post-exercise adiponectin was greater and leptin and high-sensitivity C-reactive protein were lower in normal-weight than in obese pre- and early pubertal boys, while high sensitivity IL-6 was greater in obese than in normal-weight pre-pubertal boys. In pre-pubertal obese boys: at baseline, high-sensitivity C-reactive protein correlated negatively with catalase; high sensitivity IL-6 correlated positively with protein carbonyls; Delta (difference during exercise) adiponectin correlated positively with Delta catalase. In all boys: at baseline, high sensitivity IL-6 correlated positively with leptin and was the best negative and the second best positive predictor for post-exercise glutathione/oxidized glutathione and protein carbonyls, respectively; leptin was the best negative predictor for post-exercise glutathione; waist to height ratio was the best positive predictor for post-exercise thiobarbitouric acid reactive substances; body mass index z-score and adiponectin were, respectively, the best positive predictor for post-exercise protein carbonyls and catalase.
   In all subjects, leptin and adiponectin predict negatively and positively anti-oxidation, respectively, while high sensitivity IL-6 predicts positively and negatively pro- and anti-oxidation, respectively. High-sensitivity C-reactive protein is increased and negatively associated with anti-oxidation in pre-pubertal obese boys, suggesting that childhood obesity is associated with aseptic inflammation and oxidative stress.
C1 [Paltoglou, George; Valsamakis, George; Mastorakos, George] Univ Athens, Aretaie Hosp, Endocrine Unit, Fac Med, Athens, Greece.
   [Paltoglou, George; Kanaka-Gantenbein, Christina; Chrousos, George P.] Univ Athens, Aghia Sophia Childrens Hosp, Dept Pediat 1, Fac Med, Athens, Greece.
   [Schoina, Maria; Avloniti, Alexandra; Chatzinikolaou, Athanasios] Democritus Univ Thrace, Dept Phys Educ & Sports Sci, Komotini, Greece.
   [Salakos, Nicolaos] Univ Athens, Aretaie Hosp, Dept Obstet & Gynecol 2, Fac Med, Athens, Greece.
   [Margeli, Alexandra; Skevaki, Chrysanthi; Papassotiriou, Ioannis] Aghia Sophia Childrens Hosp, Dept Clin Biochem, Athens, Greece.
   [Papagianni, Maria] Aristotle Univ Thessaloniki, Pediat Endocrinol Unit, Hippokrate Gen Hosp, Sch Med,Dept Pediat 3, Thessaloniki, Greece.
   [Fatouros, Ioannis G.] Univ Thessaly, Dept Phys Educ & Sports Sci, Trikala, Greece.
C3 National & Kapodistrian University of Athens; The Aghia Sophia
   Children's Hospital; National & Kapodistrian University of Athens;
   Democritus University of Thrace; National & Kapodistrian University of
   Athens; The Aghia Sophia Children's Hospital; Aristotle University of
   Thessaloniki; University of Thessaly
RP Mastorakos, G (corresponding author), Univ Athens, Aretaie Hosp, Endocrine Unit, Fac Med, Athens, Greece.
EM mastorakg@ath.forthnet.gr
RI Avloniti, Alexandra/AAL-4715-2021; Papagianni, Maria/AGC-9926-2022;
   Chatzinikolaou, Athanasios/AAL-4463-2021; Kanaka-Gantenbein,
   Christina/AAP-3697-2020; Salakos, Nicolaos/AAA-4198-2020; Chrousos,
   George/G-8702-2011; Paltoglou, George/B-6944-2019
OI Avloniti, Alexandra/0000-0003-1406-039X; Paltoglou,
   George/0000-0003-4300-7061; PAPAGIANNI, MARIA/0000-0002-1434-7318
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NR 49
TC 42
Z9 44
U1 0
U2 7
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1355-008X
EI 1559-0100
J9 ENDOCRINE
JI Endocrine
PD MAR
PY 2017
VL 55
IS 3
BP 925
EP 933
DI 10.1007/s12020-017-1227-3
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA EL9UZ
UT WOS:000394966900029
PM 28092067
DA 2025-06-11
ER

PT J
AU Abd-Elrazek, AM
   Ibrahim, SR
   El-dash, HA
AF Abd-Elrazek, Areeg M.
   Ibrahim, Shaimaa R.
   El-dash, Heba A.
TI The ameliorative effect of Apium graveolens & curcumin
   against Non-alcoholic fatty liver disease induced by high fructose-high
   fat diet in rats
SO FUTURE JOURNAL OF PHARMACEUTICAL SCIENCES
LA English
DT Article
DE Non-alcoholic fatty liver; Celery; Curcumin; High fat-high fructose;
   Oxidative stress; Insulin resistance
ID OXIDATIVE STRESS; CELERY SEED; SERUM; MODEL; HYPERLIPIDEMIA; MECHANISM;
   PROPOLIS; EXTRACTS
AB Background: Non-alcoholic fatty liver disease (NAFLD) is a condition resulting from fat aggregates in liver cells and is associated with metabolic syndrome, obesity, and oxidative stress. The present work was designed to investigate the role of celery and curcumin against high-fructose-high-fat (HFHF) diet-induced NAFLD in rats. Thirty male rats were classified into five groups: GP(1): control group (rats were fed a normal control diet), GP(2): HFHF group as a positive control (rats were fed a HFHF diet) for 20 weeks, GP(3): HFHF +/- sily group, GP(4): HFHF +/- celery group, and GP(5): HFHF +cur group (rats in 3, 4, and 5 were treated as in the HFHF group for 16 weeks, then combined treatment daily by gavage for 4 weeks with either silymarin (as a reference drug, 50 mg/kg bw) or celery (300 mg/kg bw) or curcumin (200 mg/kg bw), respectively. The progression of NAFLD was evaluated by estimating tissue serum liver enzymes, glycemic profile, lipid profile, oxidative stress markers in liver tissue, and histopathological examination. Moreover, DNA fragmentation and the released lysosomal enzymes (acid phosphatase, beta-galactosidase, and N-acetyl-B-glucosaminidase were estimated.
   Results: Our results showed that HFHF administration for 16 weeks caused liver enzymes elevation, hyperglycemia, and hyperlipidemia. Furthermore, increased hepatic MDA levels along with a decline in GSH levels were observed in the HFHF group as compared to the control group. The results were confirmed by a histopathological study, which showed pathological changes in the HFHF group. DNA fragmentation was also observed, and the lysosomal enzyme activities were increased. On the other hand, oral supplementation of celery and cur improved all these changes compared with positive control groups and HFHF+sily (as a reference drug). Moreover, celery, as well as curcumin co-treatment, reduced HFHF-enhanced DNA fragmentation and inhibited elevated lysosomal enzymes. The celery combined treatment showed the most pronounced ameliorative impact, even more than silymarin did.
   Conclusion: Our findings suggest that celery and curcumin consumption may exhibit ameliorative impacts against NALFD progression, while celery showed more ameliorative effect in all parameters.
C1 [Abd-Elrazek, Areeg M.] Natl Org Drug Control & Res NODCAR, Dept Physiol, Giza, Egypt.
   [Ibrahim, Shaimaa R.] Natl Org Drug Control & Res NODCAR, Dept Mol Drug Evaluat, Giza, Egypt.
   [El-dash, Heba A.] Fayoum Univ, Fac Sci, Zool Dept, Al Fayyum, Egypt.
C3 National Organization for Drug Control & Research (NODCAR); National
   Organization for Drug Control & Research (NODCAR); Egyptian Knowledge
   Bank (EKB); Fayoum University
RP El-dash, HA (corresponding author), Fayoum Univ, Fac Sci, Zool Dept, Al Fayyum, Egypt.
EM had01@fayoum.edu.eg
RI Abdelrazek, Areeg/AAF-6002-2019; Mohamed, Gamal/H-9658-2012
OI abdelrazek, areeg/0000-0002-0995-1983; Mohamed,
   Gamal/0000-0002-2971-6008
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NR 56
TC 5
Z9 5
U1 0
U2 6
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 2314-7245
EI 2314-7253
J9 FUTUR J PHARM SCI
JI Futur. J. Pharm. Sci.
PD MAY 13
PY 2022
VL 8
IS 1
AR 26
DI 10.1186/s43094-022-00416-6
PG 11
WC Pharmacology & Pharmacy
WE Emerging Sources Citation Index (ESCI)
SC Pharmacology & Pharmacy
GA 1F4HF
UT WOS:000795129100001
OA gold
DA 2025-06-11
ER

PT J
AU Kostecka, D
   Schneider-matyka, D
   Barczak, K
   Starczewska, M
   Szkup, M
   Ustianowski, P
   Brodowski, J
   Grochans, E
AF Kostecka, D.
   Schneider-matyka, D.
   Barczak, K.
   Starczewska, M.
   Szkup, M.
   Ustianowski, P.
   Brodowski, J.
   Grochans, E.
TI The effect of vitamin D levels on lipid, glucose profiles and depression
   in perimenopausal women
SO EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
LA English
DT Article
DE Vitamin D; Lipid; Glucose level; Depressiveness; Menopause
ID BONE-MINERAL DENSITY; POSTMENOPAUSAL WOMEN; PARATHYROID-HORMONE;
   METABOLIC SYNDROME; D SUPPLEMENTATION; D DEFICIENCY; D INADEQUACY;
   SYMPTOMS; MENOPAUSE; ADULTS
AB OBJECTIVE: Vitamin D deficiency is a significant problem that affects the population living in most countries. This issue is independent by place of residence, sex. age or skin color. It is mainly influenced by the environment we live in and by an unhealthy lifestyle, including bad eating habits.
   The aim of this study was to evaluate lipid profile. glucose levels. and vitamin D levels. considering sociodemographic variables, smoking and alcohol consumption in perimenopausal women. Depressive mood was also assessed considering sociodemographic variables and vitamin D levels.
   PATIENTS AND METHODS: The study was conducted on a group of 191 women and performed in two stages. The first of them was carried out using a diagnostic survey with the use of a technique questionnaire. The applied research instruments were the author's questionnaire (concerning sociodemographic and selected medical data). and the Beck Depression Inventory. The second stage of the study involved the collection of peripheral blood from each respondent. in order to determine lipid profile, glycemia and serum vitamin D levels.
   RESULTS: The age of the female respondents ranged from 45 to 65 years, mean age was 53.1 +/- 5.37 years. median 53 years. Vitamin D levels were below normal in 78%; 77% had elevated total cholesterol levels: 91.6% of the respondents had high density lipoprotein (HDL) cholesterol levels within the normal range; 64.4% was characterized by too high (low-density lipoprotein) LDL cholesterol, and 84.8% of the women showed normal triglyceride levels. Among the respondents. 91.1% had normal glycemic levels. Analysis of the collected data showed a weak negative correlation between serum vitamin D levels and the levels of total cholesterol (rho=-0.14; p=0.05), LDL cholesterol (rho=-0.16; p=0.026), and triglycerides (rho=0.22: p=0.002). Only in the case of HDL cholesterol (p=0.067), there was no statistically significant correlation. There were also no statistically significant correlations between serum vitamin D levels and glycemia or severity of depression.
   CONCLUSIONS: 1. The majority of the women did not manifest depressive disorders. Of all factors analyzed, only education was associated with the severity of depressiveness. 2. Smoking adversely affected serum vitamin D levels in the studied women. 3. The cessation of menstruation affected carbohydrate metabolism and vitamin D levels. Blood glucose levels increased with the age of the studied women. 4. Relationships were found between the levels of vitamin D and the levels of total cholesterol, LDL cholesterol, and triglycerides. Therefore, it is important to maintain normal vitamin D levels.
C1 [Kostecka, D.] Independent Voivodship Combined Hosp Szczecin, Childrens Observat & Infect Ward, Childrens Ward, Szczecin, Poland.
   [Schneider-matyka, D.; Starczewska, M.; Szkup, M.; Ustianowski, P.; Grochans, E.] Pomeranian Med Univ, Dept Nursing, Szczecin, Poland.
   [Barczak, K.] Pomeranian Med Univ, Dept Conservat Dent & Endodont, Szczecin, Poland.
   [Brodowski, J.] Pomeranian Med Univ, Primary Care Dept, Szczecin, Poland.
C3 Pomeranian Medical University; Pomeranian Medical University; Pomeranian
   Medical University
RP Schneider-matyka, D (corresponding author), Pomeranian Med Univ, Dept Nursing, Szczecin, Poland.
EM daria.schneidermatyka@gmail.com
RI Barczak, Katarzyna/A-7331-2015; Ustianowski, Przemysław/I-2405-2014;
   Grochans, Elżbieta/K-8659-2014
FU Pomeranian Medical University of Szczecin
FX Financial resources for the project and funds for covering the costs to
   publication come exclusively from the Pomeranian Medical University of
   Szczecin.
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NR 81
TC 5
Z9 6
U1 0
U2 6
PU VERDUCI PUBLISHER
PI ROME
PA VIA GREGORIO VII, ROME, 186-00165, ITALY
SN 1128-3602
J9 EUR REV MED PHARMACO
JI Eur. Rev. Med. Pharmacol. Sci.
PY 2022
VL 26
IS 10
BP 3493
EP 3505
PG 13
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 2A0ZC
UT WOS:000809239500013
PM 35647830
DA 2025-06-11
ER

PT J
AU Babar, ZUD
   Kousar, R
   Murtaza, G
   Azhar, S
   Khan, SA
   Curley, L
AF Babar, Zaheer-Ud-Din
   Kousar, Rozina
   Murtaza, Ghulam
   Azhar, Saira
   Khan, Shujaat Ali
   Curley, Louise
TI Randomized controlled trials covering pharmaceutical care and medicines
   management: A systematic review of literature
SO RESEARCH IN SOCIAL & ADMINISTRATIVE PHARMACY
LA English
DT Review
ID CONTROLLED DIABETES-MELLITUS; PRIMARY-HEALTH-CARE; BLOOD-PRESSURE;
   MEDICATION ADHERENCE; CARDIOVASCULAR RISK; PHARMACIST INTERVENTION;
   HYPERTENSIVE PATIENTS; COMMUNITY PHARMACY; HOSPITAL ADMISSION; METABOLIC
   SYNDROME
AB Objective: To review the effects of pharmaceutical care on hospitalizations, mortality and clinical outcomes in patients.
   Methods: Systematic searches were conducted in MEDLINE, EMBASE and International Pharmaceutical Abstracts (IPA) databases to identify studies that were published between 2004 and January 2017. Studies included in this review were randomized controlled trials (RCTs) that spanned across both community and hospital settings. Using strict inclusion/exclusion criteria studies were included if they reported level 1 or 2 outcomes in the hierarchy of outcome measure i.e. clinical and surrogate outcomes (e.g. blood pressure (BP) control, blood glucose level, cholesterol BMI). Each study was assessed for quality using the Jadad scoring system.
   Results: Fifty-four RCTs were included in the present review. Forty-six of these studies ranked high quality according to the Jadad scoring system. Studies were categorized into their general condition groups. Interventions in patients with diabetes, depression, respiratory disorders, cardiovascular disorders, epilepsy, osteoporosis, and interventions in older adults were identified. In the majority of studies pharmaceutical care was found to lead to significant improvements in clinical outcomes and/or hospitalizations when compared to the non-intervention group. Some conditions had a large number of RCTs, for example for cardiovascular conditions and in diabetes. Statistically significant improvements were seen in the majority of the studies included for both of these conditions, with studies indicating positive clinical outcomes and/or hospitalizations rates. Within the cardiovascular condition, a subset of studies, focusing on cardiac heart failure and coronary heart disease, had more mixed results. In other conditions the number of RCTs conducted was small and the evidence did not show improvements after pharmaceutical care, i.e. in depression, osteoporosis, and epilepsy. The majority of interventions were face to face interactions with patients, whilst a smaller number were conducted via the telephone and one via a webbased system. Patient education was a key component of most interventions, either verbal and/or written. Longitudinal data, post intervention cessation, was not collected in the majority of cases.
   Conclusions: RCTs conducted to evaluate pharmaceutical care appear to be effective in improving patient short-term outcomes for a number of conditions including diabetes and cardiovascular conditions, however, other conditions such as depression are less well researched. Future research should attempt to evaluate the conditions where there is a lack of data, whether the positive effects of pharmaceutical care persist in patient populations after the interventions cease and what the long-term clinical outcomes would be of continued pharmaceutical care. (C) 2017 Elsevier Inc. All rights reserved.
C1 [Babar, Zaheer-Ud-Din] Univ Huddersfield, Sch Appl Sci, Dept Pharm, Huddersfield HD1 3DH, W Yorkshire, England.
   [Kousar, Rozina; Murtaza, Ghulam; Azhar, Saira; Khan, Shujaat Ali] COMSATS Inst Informat Technol, Dept Pharm, Abbottabad, Khyber Pakhtunk, Pakistan.
   [Babar, Zaheer-Ud-Din; Curley, Louise] Univ Auckland, Sch Pharm, Private Mail Bag 92019, Auckland, New Zealand.
C3 University of Huddersfield; COMSATS University Islamabad (CUI);
   University of Auckland
RP Babar, ZUD (corresponding author), Univ Huddersfield, Sch Appl Sci, Dept Pharm, Huddersfield HD1 3DH, W Yorkshire, England.
EM z.babar@hud.ac.uk
RI Murtaza, Ghulam/AAK-6538-2020; Babar, Zaheer-Ud-Din/AFQ-8221-2022
FU Higher Education Commission (HEC), Government of Pakistan
FX Rozina Kousar is a Ph.D. student and received funding from Higher
   Education Commission (HEC), Government of Pakistan to undertake six
   months study at the School of Pharmacy, University of Auckland.
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NR 89
TC 25
Z9 26
U1 0
U2 17
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1551-7411
EI 1934-8150
J9 RES SOC ADMIN PHARM
JI Res. Soc. Adm. Pharm.
PD JUN
PY 2018
VL 14
IS 6
BP 521
EP 539
DI 10.1016/j.sapharm.2017.06.008
PG 19
WC Public, Environmental & Occupational Health; Pharmacology & Pharmacy
WE Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; Pharmacology & Pharmacy
GA GJ0UW
UT WOS:000434970900017
PM 28651923
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Fajrani, AM
   Sulchan, M
   Muis, SF
   Purnomo, HD
   Djamiatun, K
   Karlowee, V
   Ardiaria, M
AF Fajrani, Alifia Mukti
   Sulchan, Mohamad
   Muis, Siti Fatimah
   Purnomo, Hery Djagat
   Djamiatun, Kis
   Karlowee, Vega
   Ardiaria, Martha
TI Effect of black garlic on visceral fat, oxidative stress and insulin
   resistance in nonalcoholic fatty liver disease rats
SO NUTRITION & FOOD SCIENCE
LA English
DT Article
DE Oxidative stress; Visceral fat; NAFLD; Black garlic; Insulin resistance
ID METABOLIC SYNDROME; EXTRACT; SUPPLEMENTATION
AB Purpose
   This paper aims to determine the effect of black garlic (BG) on visceral fat, oxidative stress and insulin resistance (IR) compared with metformin and vitamin E in nonalcoholic fatty liver disease (NAFLD) rats.
   Design/methodology/approach
   A randomized post-test only design with control group was used in this study. Rats were given high-fat fructose diet enriched with 1.25% cholesterol and 0.5% cholic acid for eight weeks to induce NALFD condition. The administration of BG dose of 450 mg/200 gBW, 900 mg/200 gBW and 1350 mg/200 gBW with a comparative control of 45 mg/200 gBW of metformin and vitamin E of 9 IU/200 gBW were given for four weeks via oral gavage to reduce visceral fat, oxidative stress and improve IR. Statistical analyses were performed to examine differences between groups with one-way analysis of variance and nonparametrics test.
   Findings
   Rats given with three different doses of BG for four weeks did not reduce body weight from 244 +/- 4.4 to 284 +/- 4.6 g, 242 +/- 2.5 to 272 +/- 3.1 g and 240 +/- 2.4 to 270 +/- 3.6 g, respectively, but significantly reduced visceral fat (p = 0.001) on BG groups with 3.7 +/- 1.3, 2.7 +/- 0.7 and 1.8 +/- 0.6 g, respectively. BG improved oxidative stress (p = 0.001) with malondialdehyde level 5.1 +/- 0.2, 3.0 +/- 0.06 and 2.3 +/- 0.06 ng/mL, respectively, but did not better than vitamin E group 1 +/- 0.03 ng/mL. Significant (p = 0.001) improvement on insulin resistance with homeostatic model assessment IR in BG groups were 5.3 +/- 0.1, 4.4 +/- 0.1 and 4 +/- 0.1, respectively, but not as good as metformin group 3.7 +/- 0.1.
   Research limitations/implications
   Based on the experiment, there are several limitations including small sample size, performed on animal models in a relatively short time, did not examine organosulfurs compound (OSC) content of BG specifically and OSC affects metabolism in NAFLD remains unclear and will require further investigation.
   Practical implications
   BG is a functional food made from heated fresh garlic owing to the Maillard reaction and the organosulfur compounds as antioxidants. The higher the dose of BG, the greater the improvement in visceral fat, oxidative stress and IR in model NAFLD rats.
   Social implications
   NAFLD is a liver disorder caused by excessive fat and energy intake, the treatment strategies among others through diet modification.
   Originality/value
   In model NAFLD rats, BG administration improved NALFD markers but did not better rather than the metformin and vitamin E result.
C1 [Fajrani, Alifia Mukti; Sulchan, Mohamad; Muis, Siti Fatimah; Ardiaria, Martha] Diponegoro Univ, Dept Nutr Sci, Semarang, Indonesia.
   [Purnomo, Hery Djagat] Diponegoro Univ, Med Fac, Dr Kariadi Gen Hosp, Div Gastroenterohepatol,Dept Internal Med, Semarang, Indonesia.
   [Djamiatun, Kis] Diponegoro Univ, Fac Med, Dept Gen Med, Semarang, Indonesia.
   [Djamiatun, Kis] Diponegoro Univ, Fac Med, Dept Biomed Sci, Semarang, Indonesia.
   [Karlowee, Vega] Diponegoro Univ, Fac Med, Dept Anat Pathol, Semarang, Indonesia.
C3 Diponegoro University; Diponegoro University; Diponegoro University;
   Diponegoro University; Diponegoro University
RP Purnomo, HD (corresponding author), Diponegoro Univ, Med Fac, Dr Kariadi Gen Hosp, Div Gastroenterohepatol,Dept Internal Med, Semarang, Indonesia.
EM aliphia@gmail.com; mohsulchan@gmail.com; sitifatimahmuis@gmail.com;
   herydjagat@yahoo.co.id; kisdjamiatun@gmail.com; ve94karlowee@gmail.com;
   ardiaria@yahoo.com
RI Karlowee, Vega/HLP-4435-2023
OI Karlowee, Vega/0000-0003-2227-6449; Fajrani, Alifia
   Mukti/0000-0001-8481-4834
FU Agency for the Assessment and Application of Technology, Indonesia;
   Faculty of Medicine Diponegoro University, Indonesia
   [1182/UN7.5.4.2.1/PP/PM/2020]
FX This work was supported by the Agency for the Assessment and Application
   of Technology, Indonesia, for the Natural Black Garlic Lanang Premium
   products and the Faculty of Medicine Diponegoro University, Indonesia,
   for a grant funding number 1182/UN7.5.4.2.1/PP/PM/2020.
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NR 52
TC 4
Z9 4
U1 0
U2 0
PU EMERALD GROUP PUBLISHING LTD
PI BINGLEY
PA HOWARD HOUSE, WAGON LANE, BINGLEY BD16 1WA, W YORKSHIRE, ENGLAND
SN 0034-6659
EI 1758-6917
J9 NUTR FOOD SCI
JI Nutr. Food Sci.
PD SEP 6
PY 2021
VL 51
IS 7
BP 1084
EP 1095
DI 10.1108/NFS-11-2020-0439
EA MAY 2021
PG 12
WC Food Science & Technology
WE Emerging Sources Citation Index (ESCI)
SC Food Science & Technology
GA UL6KW
UT WOS:000653184000001
DA 2025-06-11
ER

PT J
AU Baye, E
   Menon, K
   de Courten, MPJ
   Earnest, A
   Cameron, J
   de Courten, B
AF Baye, Estifanos
   Menon, Kirthi
   de Courten, Maximilian P. J.
   Earnest, Arul
   Cameron, James
   de Courten, Barbora
TI Does supplementation with carnosine improve cardiometabolic health and
   cognitive function in patients with prediabetes and type 2 diabetes?
   study protocol for a randomised, double-blind, placebo-controlled trial
SO BMJ OPEN
LA English
DT Article
ID GLYCATION END-PRODUCTS; MICRONUCLEUS CYTOME ASSAY; QUALITY-OF-LIFE;
   PARKINSONS-DISEASE; GLUCOSE-METABOLISM; CARDIOVASCULAR-DISEASE; EXERCISE
   PERFORMANCE; MICE; RISK; ASSOCIATION
AB Introduction Carnosine, an over-the-counter food supplement, has a promising potential for the prevention and treatment of chronic diseases such as type 2 diabetes (T2DM), cardiovascular and neurodegenerative diseases through its anti-inflammatory, antiglycation, antioxidative and chelating effects. We have previously shown that supplementation with carnosine preserves insulin sensitivity and secretion in non-diabetic overweight and obese individuals. The effect of carnosine on cardiometabolic risk and related cognitive outcomes in patients with pre-diabetes and T2DM has thus far not been studied. We therefore aim to investigate whether supplementation with carnosine improves cardiometabolic health and cognitive function in patients with pre-diabetes and T2DM.
   Methods and analysis We will employ a parallel design randomised controlled trial. Fifty participants with prediabetes (impaired fasting glycaemia and impaired glucose tolerance) and T2DM (with HbA1c level <8%) aged between 18 to 70 years will be randomly assigned to the intervention or control group. At baseline, participants will undergo a medical review and series of tests including anthropometric measurements (body mass index, a dual X-ray absorptiometry and peripheral quantitative computed tomography scan), an oral glucose tolerance test, cardiovascular measurements (central blood pressure, endothelial function and arterial stiffness), cognitive function, physical activity measurement, heart rate variability and liver fibroscan as well as questionnaires to assess dietary habits, sleep quality, depression and quality of life. The intervention group will receive 2 g of carnosine daily in two divided doses while the control group will receive identical placebo capsules for 14 weeks. All baseline measurements will be repeated at the end of the intervention. The change in glycaemic, cardiovascular and cognitive parameters as well as other measures will be compared between the groups.
   Ethics and dissemination This study is approved by the Human Research Ethics Committee of Monash Health and Monash University, Australia. The findings will be disseminated via peer-reviewed publications and conference presentations.
C1 [Baye, Estifanos; Menon, Kirthi; de Courten, Barbora] Monash Univ, Sch Publ Hlth & Prevent Med, Monash Ctr Hlth Res & Implementat, Melbourne, Vic, Australia.
   [de Courten, Maximilian P. J.] Victoria Univ, Coll Hlth & Biomed, Ctr Chron Dis, Melbourne, Vic, Australia.
   [Earnest, Arul] Monash Univ, Sch Publ Hlth Prevent Med, Dept Epidemiol & Prevent Med, Melbourne, Vic, Australia.
   [Cameron, James] Monash Hlth, Monash Heart, Monash Cardiovasc Res Ctr, Melbourne, Vic, Australia.
   [de Courten, Barbora] Monash Hlth, Diabet & Vasc Med Unit, Melbourne, Vic, Australia.
C3 Monash University; Victoria University; Monash University; Monash
   Health; Monash Health
RP de Courten, B (corresponding author), Monash Univ, Sch Publ Hlth & Prevent Med, Monash Ctr Hlth Res & Implementat, Melbourne, Vic, Australia.; de Courten, B (corresponding author), Monash Hlth, Diabet & Vasc Med Unit, Melbourne, Vic, Australia.
EM barbora.decourten@monash.edu
RI Cameron, james/GQP-4595-2022; de Courten, Barbora/B-3308-2012; de
   Courten, Maximilian/B-3300-2012; Earnest, Arul/L-4747-2013
OI de Courten, Maximilian/0000-0001-9997-9359; Cameron,
   James/0000-0003-0589-0367; Baye, Estifanos/0000-0002-2937-356X; Earnest,
   Arul/0000-0003-2693-5034
FU Royal Australasian College of Physicians; Diabetes Australia Research
   Trust; Foundation for High Blood Pressure Research; CASS foundation;
   Australian National Heart Foundation; Australian Diabetes Society
FX This study is supported by the Royal Australasian College of Physicians,
   Diabetes Australia Research Trust, Foundation for High Blood Pressure
   Research, CASS foundation, Australian National Heart Foundation and
   Australian Diabetes Society. Carnosine supplement (CarnopureTM) is
   received from Flamma S.p.A, Italy. These funding bodies have no role in
   the design of the study and collection, analysis, and interpretation of
   data and in writing of the manuscript.
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NR 80
TC 15
Z9 16
U1 0
U2 13
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2044-6055
J9 BMJ OPEN
JI BMJ Open
PD SEP
PY 2017
VL 7
IS 9
AR e017691
DI 10.1136/bmjopen-2017-017691
PG 10
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA FJ3RY
UT WOS:000412650700255
PM 28864708
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Kovacevic, S
   Brkljacic, J
   Milutinovic, DV
   Gligorovska, L
   Bursac, B
   Elakovic, I
   Djordjevic, A
AF Kovacevic, Sanja
   Brkljacic, Jelena
   Vojnovic Milutinovic, Danijela
   Gligorovska, Ljupka
   Bursac, Biljana
   Elakovic, Ivana
   Djordjevic, Ana
TI Fructose Induces Visceral Adipose Tissue Inflammation and Insulin
   Resistance Even Without Development of Obesity in Adult Female but Not
   in Male Rats
SO FRONTIERS IN NUTRITION
LA English
DT Article
DE fructose diet; inflammation; visceral adipose tissue; insulin
   resistance; female rats
ID NECROSIS-FACTOR-ALPHA; NF-KAPPA-B; OXIDATIVE STRESS; METABOLIC SYNDROME;
   DIETARY FRUCTOSE; PROTECTS MICE; RISK-FACTORS; PPAR-GAMMA; EXPRESSION;
   FAT
AB Introduction: Obesity and related metabolic disturbances are frequently related to modern lifestyle and are characterized by excessive fructose intake. Visceral adipose tissue (VAT) inflammation has a central role in the development of insulin resistance, type 2 diabetes (T2D), and metabolic syndrome. Since sex-related differences in susceptibility and progression of metabolic disorders are not yet fully understood, our aim was to examine inflammation and insulin signaling in VAT of fructose-fed female and male adult rats.Methods: We analyzed effects of 9-week 10% fructose-enriched diet on energy intake, VAT mass and histology, and systemic insulin sensitivity. VAT insulin signaling and markers of VAT inflammation, and antioxidative defense status were also evaluated.Results: The fructose diet had no effect on VAT mass and systemic insulin signaling in the female and male rats, while it raised plasma uric acid, increased PPAR gamma level in the VAT, and initiated the development of a distinctive population of small adipocytes in the females. Also, adipose tissue insulin resistance, evidenced by increased PTP1B and insulin receptor substrate 1 (IRS1) inhibitory phosphorylation and decreased Akt activity, was detected. In addition, fructose stimulated the nuclear accumulation of NF kappa B, increased expression of proinflammatory cytokines (IL-1 beta, IL-6, and TNF alpha), and protein level of macrophage marker F4/80, superoxide dismutase 1, and glutathione reductase. In contrast to the females, the fructose diet had no effect on plasma uric acid and VAT inflammation in the male rats, but less prominent alterations in VAT insulin signaling were observed.Conclusion: Even though dietary fructose did not elicit changes in energy intake and led to obesity in the females, it initiated the proliferation of small-sized adipocytes capable of storing fats further. In contrast to the males, this state of VAT was accompanied with enhanced inflammation, which most likely contributed to the development of insulin resistance. The observed distinction could possibly originate from sex-related differences in uric acid metabolism. Our results suggest that VAT inflammation could precede obesity and start even before the measurable increase in VAT mass, making it a silent risk factor for the development of T2D. Our results emphasize that adipose tissue dysfunction, rather than its simple enlargement, could significantly contribute to the onset and development of obesity and related metabolic disorders.
C1 [Kovacevic, Sanja; Brkljacic, Jelena; Vojnovic Milutinovic, Danijela; Gligorovska, Ljupka; Bursac, Biljana; Elakovic, Ivana; Djordjevic, Ana] Univ Belgrade, Natl Inst Republ Serbia, Inst Biol Res Sinisa Stankov, Dept Biochem, Belgrade, Serbia.
C3 University of Belgrade
RP Djordjevic, A (corresponding author), Univ Belgrade, Natl Inst Republ Serbia, Inst Biol Res Sinisa Stankov, Dept Biochem, Belgrade, Serbia.
EM djordjevica@ibiss.bg.ac.rs
RI Kovacevic, Sanja/JZC-6964-2024; Brkljacic, Jelena/JQW-4422-2023;
   Vojnović Milutinović, Danijela/AAX-8926-2021; Gligorovska,
   Ljupka/JMQ-5170-2023; Djordjevic, Ana/E-7840-2016
OI Gligorovska, Ljupka/0000-0003-1415-4599; Bursac,
   Biljana/0000-0003-2225-678X; Vojnovic Milutinovic,
   Danijela/0000-0002-2584-5048; Brkljacic, Jelena/0000-0003-1978-8646;
   Djordjevic, Ana/0000-0002-7042-1631; Kovacevic,
   Sanja/0000-0002-9854-1934
FU Ministry of Education, Science and Technological Development of the
   Republic of Serbia [45103-9/2021-14/200007]; Swiss National Science
   Foundation [SCOPES JRP IZ73Z0_152331]
FX This study was supported by the Ministry of Education, Science and
   Technological Development of the Republic of Serbia
   (45103-9/2021-14/200007) and Swiss National Science Foundation, Grant
   SCOPES JRP IZ73Z0_152331.
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NR 115
TC 17
Z9 18
U1 0
U2 11
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD NOV 11
PY 2021
VL 8
AR 749328
DI 10.3389/fnut.2021.749328
PG 18
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA XI4UN
UT WOS:000726108700001
PM 34869524
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Bravo, MA
   Fang, F
   Hancock, DB
   Johnson, EO
   Harris, KM
AF Bravo, Mercedes A.
   Fang, Fang
   Hancock, Dana B.
   Johnson, Eric O.
   Harris, Kathleen Mullan
TI Long-term air pollution exposure and markers of cardiometabolic health
   in the National Longitudinal Study of Adolescent to Adult Health (Add
   Health)
SO ENVIRONMENT INTERNATIONAL
LA English
DT Article
DE Air pollution; Cardiometabolic health; Young adult health; Longitudinal;
   Multi-year; Long-term] air pollution exposure; Early life exposure
ID AIRBORNE PARTICULATE MATTER; ARTERIAL STIFFNESS; CARDIOVASCULAR RISK;
   OXIDATIVE STRESS; BLOOD-PRESSURE; ATHEROSCLEROSIS; ASSOCIATION;
   MORTALITY; COHORT; POPULATIONS
AB Background: Air pollution exposure is associated with cardiovascular morbidity and mortality. Although exposure to air pollution early in life may represent a critical window for development of cardiovascular disease risk factors, few studies have examined associations of long-term air pollution exposure with markers of cardiovascular and metabolic health in young adults. Objectives: By combining health data from the National Longitudinal Study of Adolescent to Adult Health (Add Health) with air pollution data from the Fused Air Quality Surface using Downscaling (FAQSD) archive, we: (1) calculated multi-year estimates of exposure to ozone (O3) and particulate matter with an aerodynamic diameter & LE; 2.5 & mu;m (PM2.5) for Add Health participants; and (2) estimated associations between air pollution exposures and multiple markers of cardiometabolic health. Methods: Add Health is a nationally representative longitudinal cohort study of over 20,000 adolescents aged 12-19 in the United States (US) in 1994-95 (Wave I). Participants have been followed through adolescence and into adulthood with five in-home interviews. Estimated daily concentrations of O3 and PM2.5 at census tracts were obtained from the FAQSD archive and used to generate tract-level annual averages of O3 and PM2.5 concentrations. We estimated associations between average O3 and PM2.5 exposures from 2002 to 2007 and markers of cardiometabolic health measured at Wave IV (2008-09), including hypertension, hyperlipidemia, body mass index (BMI), diabetes, C-reactive protein, and metabolic syndrome. Results: The final sample size was 11,259 individual participants. The average age of participants at Wave IV was 28.4 years (range: 24-34 years). In models adjusting for age, race/ethnicity, and sex, long-term O3 exposure (2002-07) was associated with elevated odds of hypertension, with an odds ratio (OR) of 1.015 (95% confidence interval [CI]: 1.011, 1.029); obesity (1.022 [1.004, 1.040]); diabetes (1.032 [1.009,1.054]); and metabolic syndrome (1.028 [1.014, 1.041]); PM2.5 exposure (2002-07) was associated with elevated odds of hypertension (1.022 [1.001, 1.045]). Conclusion: Findings suggest that long-term ambient air pollution exposure, particularly O3 exposure, is associated with cardiometabolic health in early adulthood.
C1 [Bravo, Mercedes A.] Duke Univ, Global Hlth Inst, Sch Med, Durham, NC 27708 USA.
   [Fang, Fang; Hancock, Dana B.; Johnson, Eric O.] RTI Int, Genom & Translat Res Ctr, Res Triangle Pk, NC USA.
   [Johnson, Eric O.] RTI Int, Fellow Program, Res Triangle Pk, NC USA.
   [Harris, Kathleen Mullan] Univ North Carolina Chapel Hill, Carolina Populat Ctr, Chapel Hill, NC USA.
   [Harris, Kathleen Mullan] Univ North Carolina Chapel Hill, Dept Sociol, Chapel Hill, NC USA.
C3 Duke University; Research Triangle Institute; Research Triangle
   Institute; University of North Carolina; University of North Carolina
   Chapel Hill; University of North Carolina School of Medicine; University
   of North Carolina; University of North Carolina Chapel Hill; University
   of North Carolina School of Medicine
RP Bravo, MA (corresponding author), Duke Univ, Global Hlth Inst, Sch Med, Durham, NC 27708 USA.
EM mercedes.bravo@duke.edu
RI Hancock, Dana/D-8577-2012
OI FANG, FANG/0000-0001-9829-2934; Hancock, Dana/0000-0003-2240-3604;
   Johnson, Eric Otto/0000-0002-8870-1949; Bravo,
   Mercedes/0000-0003-1777-9869
FU Eunice Kennedy Shriver Na-tional Institute of Child Health and Human
   Development (NICHD) [P01 HD31921]; National Institute on Aging [U01
   AG071448, U01AG071450]; RTI University Scholars program; Whitehead
   Scholars program at Duke School of Medicine; RTI Fellow program
FX & nbsp;This research uses data from Add Health, funded by grant P01
   HD31921 (Harris) from the Eunice Kennedy Shriver Na-tional Institute of
   Child Health and Human Development (NICHD), with cooperative funding
   from 23 other federal agencies and foundations. Add Health is currently
   directed by Robert A. Hummer and funded by the National Institute on
   Aging cooperative agreements U01 AG071448 (Hummer) and U01AG071450
   (Aiello and Hummer) at the University of North Carolina at Chapel Hill.
   Add Health was designed by J. Richard Udry, Peter S. Bearman, and
   Kathleen Mullan Harris at the University of North Carolina at Chapel
   Hill. Support was provided by the RTI Uni-versity Scholars program
   (Harris), Whitehead Scholars program at Duke School of Medicine (Bravo),
   and the RTI Fellow program (Johnson).
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NR 86
TC 9
Z9 9
U1 5
U2 21
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0160-4120
EI 1873-6750
J9 ENVIRON INT
JI Environ. Int.
PD JUL
PY 2023
VL 177
AR 107987
DI 10.1016/j.envint.2023.107987
EA JUN 2023
PG 10
WC Environmental Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology
GA K0NM0
UT WOS:001013501700001
PM 37267730
OA Green Accepted, gold
DA 2025-06-11
ER

PT J
AU Yegin, ZA
   Iyidir, ÖT
   Demirtas, C
   Suyani, E
   Yetkin, I
   Pasaoglu, H
   Ilhan, Ç
   Sucak, GT
AF Yegin, Z. A.
   Iyidir, O. T.
   Demirtas, C.
   Suyani, E.
   Yetkin, I.
   Pasaoglu, H.
   Ilhan, C.
   Sucak, G. T.
TI The interplay among iron metabolism, endothelium and inflammatory
   cascade in dysmetabolic disorders
SO JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
LA English
DT Article
DE Iron overload; Ferritin; Metabolic syndrome; Diabetes mellitus;
   Osteopontin; Hepcidin
ID INSULIN-RESISTANCE; OSTEOPONTIN; PREVALENCE; ASSOCIATION; OBESITY;
   ADULTS
AB Purpose Metabolic syndrome (MetS) is considered as a proinflammatory and prothrombotic state with atherogenic risk factors including dyslipidemia, obesity and glucose intolerance. Oxidative stress is a unifying basis of several disorders including diabetes mellitus (DM) and MetS. We therefore designed this cross-sectional study to investigate the potential interaction among iron metabolism, inflammation and endothelial plexus in MetS and DM patients.
   Methods A total of 62 patients [median age 54 (23-76) years; male/female 16/46] and 18 healthy controls [median age 38 (30-64) years; male/female 6/12] were included in the study. Patient population was classified as MetS (n = 30) and DM (n = 32).
   Results Leukocyte count (p = 0.002) and osteopontin (OPN) levels (p = 0.008) were significantly higher, while C-reactive protein (CRP) (p = 0.056) and IL-6 (p = 0.059) represented a relative increase in the patient group. Leptin, endothelin 1 (ET1), hepcidin, nitric oxide synthase (NOS), erythrocyte sedimentation rate (ESR), iron, transferrin saturation (TS) and ferritin levels were not significantly different between the patient and control groups. Endothelin 1 was found to be higher in the DM group compared to MetS group (p = 0.15, p = 0.049). Leukocyte count, leptin, hepcidin, OPN, NOS, IL-6, ESR, CRP, iron, TS and ferritin levels were not different between DM and MetS groups. A positive correlation was demonstrated between leptin and OPN (p = 0.001, r = 0.360), ferritin and hepcidin (p < 0.01, r = 0.633), IL-6 and CRP (p = 0.023, r = 0.319), leptin and NOS (p = 0.005, r = 0.309) and OPN and NOS (p < 0.001, r = 0.803). There was a negative correlation between hepcidin and NOS (p = 0.009, r = -0.289). When the study cohort was divided into two particular groups based on median ferritin and hepcidin levels, hepcidin (p = 0.002), ALT (p = 0.001) and LDL (p = 0.049) levels were higher in the high-ferritin group. Nitric oxide synthase levels (p = 0.033) were lower, whereas ferritin levels (p = 0.004) were higher in the high-hepcidin group.
   Conclusion Mechanisms involved in the vicious circle of MetS including inflammation, endothelial vasculature and iron metabolism remain to be elucidated. The role of iron metabolism in this complex interaction should be confirmed with further studies.
C1 [Yegin, Z. A.; Suyani, E.; Ilhan, C.; Sucak, G. T.] Gazi Univ, Fac Med, Dept Hematol, Ankara, Turkey.
   [Iyidir, O. T.; Yetkin, I.] Gazi Univ, Fac Med, Dept Endocrinol, Ankara, Turkey.
   [Demirtas, C.; Pasaoglu, H.] Gazi Univ, Fac Med, Dept Biochem, Ankara, Turkey.
C3 Gazi University; Gazi University; Gazi University
RP Yegin, ZA (corresponding author), Gazi Univ, Fac Med, Dept Hematol, Ankara, Turkey.
EM zeyneparzuyegin@gmail.com
RI Yegin Katran, Zeynep/GQH-4060-2022; Suyanı, Elif/AGY-6192-2022; Yılmaz,
   Canan/AAT-7788-2020; Pasaoglu, Hatice/AAL-3780-2021; Turhan Iyidir,
   Ozlem/K-7904-2019
OI Turhan Iyidir, Ozlem/0000-0001-5305-6807; YILMAZ,
   CANAN/0000-0002-6799-6522
CR Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
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NR 29
TC 11
Z9 11
U1 0
U2 7
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1720-8386
J9 J ENDOCRINOL INVEST
JI J. Endocrinol. Invest.
PD MAR
PY 2015
VL 38
IS 3
BP 333
EP 338
DI 10.1007/s40618-014-0174-6
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA CC9IB
UT WOS:000350681200007
PM 25245337
DA 2025-06-11
ER

PT J
AU Vogels, RJ
   Koenders, MA
   van Rossum, EFC
   Spijker, AT
   Drexhage, HA
AF Vogels, Rogier J.
   Koenders, Manja A.
   van Rossum, Elisabeth F. C.
   Spijker, Annet T.
   Drexhage, Hemmo A.
TI T cell Deficits and Overexpression of hepatocyte growth Factor in
   antiinflammatory circulating Monocytes of Middle-aged Patients with
   Bipolar Disorder characterized by a high Prevalence of the Metabolic
   syndrome
SO FRONTIERS IN PSYCHIATRY
LA English
DT Article
DE bipolar disorder; T cell deficits; angiogenic cells; gene expression;
   hypothalamic-pituitary-adrenal axis
ID LONG-TERM CORTISOL; GENE-EXPRESSION; LIFE EVENTS; INFLAMMATION;
   ACTIVATION; MICRORNAS; ANGIOGENESIS; ASSOCIATION; RELIABILITY; SIGNATURE
AB Background: We previously reported T cell deficits and pro-inflammatory gene activation in circulating monocytes of two cohorts of bipolar disorder (BD) patients, a cohort of postpartum psychosis patients and in bipolar offspring. Pro-inflammatory gene activation occurred in two clusters of mutually correlating genes, cluster 1 for inflammation-related cytokines/factors, cluster 2 for motility, chemotaxis, and metabolic factors.
   aim: To verify these cellular immune abnormalities in yet another cohort [the bipolar stress study (BiSS) cohort] of relative old (52 years, median) BD patients and to relate immune abnormalities to hair cortisol levels, measured in this cohort and representing long-term systemic cortisol levels, and to the presence of the metabolic syndrome (MetS), which was prevalent in 29% of the BiSS patients.
   Methods: Monocyte immune gene activation (quantitative polymerase chain reaction) and T cell deficits (fluorescence-activated cell sorting analysis) were determined in 97 well-controlled, largely euthymic BiSS BD patients. Monocyte genes included the cluster 1 and 2 genes, the genes for the glucocorticoid receptor (GR)alpha and GR beta, and the gene for hepatocyte growth factor [HGF, a marker of monocyte-derived circulating angiogenic cells (CACs)]. CACs serve vessel repair. Abnormal numbers are found in patients with MetS and vascular damage.
   Results: As compared to healthy controls: (1) the pro-inflammatory cluster 1 genes were downregulated, and the GR alpha and the HGF gene were upregulated in the monocytes of the BiSS patients and (2) T cell deficits were shown (reduced numbers of lymphocytes in particular of T cells). Within the reduced T cell population, a shift had taken place in the T-helper populations: T-helper 17 and T-helper 2 increased and T regulatory cells decreased. Correlations between hair cortisol, the MetS, monocyte gene activation, and T cell deficits were not found.
   Conclusion: T cell deficits most likely are a trait phenomenon of BD, since they have also been found in the other cohorts of BD patients and in bipolar offspring. Monocytes of this cohort showed an anti-inflammatory set point, suggesting that pro-and anti-inflammation are state characteristics of BD. The monocyte gene profile indicated an increased CAC activity; the question arises whether this is due to putative vessel damage in these relatively old patients with a high prevalence of the MetS.
C1 [Vogels, Rogier J.; Drexhage, Hemmo A.] Erasmus MC, Dept Immunol, Rotterdam, Netherlands.
   [Koenders, Manja A.; Spijker, Annet T.] PsyQ, Dept Mood Disorders, Rotterdam, Netherlands.
   [van Rossum, Elisabeth F. C.] Erasmus MC, Div Endocrinol, Dept Internal Med, Rotterdam, Netherlands.
   [van Rossum, Elisabeth F. C.] Obes Ctr CGG, Rotterdam, Netherlands.
C3 Erasmus University Rotterdam; Erasmus MC; Erasmus University Rotterdam;
   Erasmus MC
RP Drexhage, HA (corresponding author), Erasmus MC, Dept Immunol, Rotterdam, Netherlands.
EM h.drexhage@erasmusmc.nl
RI van Rossum, Elisabeth/AAP-9388-2020
OI van Rossum, Elisabeth/0000-0003-0120-4913
FU EU [EU-FP7-HEALTH-F2-2008-222963,
   EU-FP7-PEOPLE-2009-IAPP-MarieCurie-286334]
FX This study was financially supported by the EU via the MOODINFLAME
   project (EU-FP7-HEALTH-F2-2008-222963) and the PSYCHAID project
   (EU-FP7-PEOPLE-2009-IAPP-MarieCurie-286334). The authors thank Thomas
   Hoogenboezem, Annemarie Wijkhuijs, Harm de Wit, Angelique van Rijswijk,
   Department of Immunology, and Laura Manenschijn, Department of Internal
   Medicine, Erasmus Medical Centre Rotterdam, for their excellent
   technical assistance.
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NR 39
TC 19
Z9 19
U1 0
U2 5
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-0640
J9 FRONT PSYCHIATRY
JI Front. Psychiatry
PD MAR 20
PY 2017
VL 8
AR 34
DI 10.3389/fpsyt.2017.00034
PG 11
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA EO4HM
UT WOS:000396656000001
PM 28373847
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Albrahim, T
   Robert, AA
AF Albrahim, Tarfa
   Robert, Asirvatham Alwin
TI Lycopene Effects on Metabolic Syndrome and Kidney Injury in Rats Fed a
   High-Fat Diet: An Experimental Study
SO ACS OMEGA
LA English
DT Article
ID OXIDATIVE STRESS; PROTEIN CARBONYLATION; ANTIOXIDANT ENZYMES; RENAL
   DAMAGE; SUPPLEMENTATION; NITRATE; LIVER
AB The frequency of overweight and obesity is rising globally. These disorders are prevalent health problems. It has a substantial correlation with a number of health issues, including cardiovascular, metabolic, and diabetes mellitus disorders. Lycopene (Lyc) is an acyclic structural isomer of fl-carotene and has powerful antioxidant properties with various promising therapeutic effects. In this study, rats fed a high-fat diet were examined to determine how lycopene affected metabolic syndrome and kidney damage. After being acclimated, rats were divided into 5 groups (n = 8/group) as follows: the first group served as the control and was fed on a normal pelleted diet (4.25% fat) until the end of the experiment. The second group (high-fat diet; HFD) was fed on a high-fat diet (45.5 kcal% fat) composed of 24% fat, 24% protein, and 41% carbohydrate. The third and fourth groups were fed on HFD and administered lycopene at 25 and 50 mg/kg bodyweight orally every day. The fifth group (standard drug group) received HFD and simvastatin (SVS; 10 mg/kg bodyweight orally daily) for 3 months. Tissue samples from the kidney were taken for determination of the biochemical parameters, lipid peroxidation (LPO), protein carbonyl (PC), reduced glutathione (GSH), total thiol group, antioxidant enzymes, namely, superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and glutathione reductase (GR), in addition to renal mRNA expression of nuclear factor erythroid 2-related factor 2 (Nrf2), renal levels of inflammatory markers [tumor necrosis factor alpha (TNF-a), interleukin-1 beta (IL-1 beta), and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-KB)], and apoptotic markers (BCL2 Associated X (Bax), B-cell lymphoma 2 (Bcl-2), and Bax/Bcl-2 ratio). When compared to the control group, the HFD group's food consumption, body weight, serum levels of glucose, uric acid, creatinine, LPO, PC, TNF-alpha, IL-1 beta, Bax, and the Bax/Bcl-2 ratio all increased significantly. In the kidney sample of HFD-fed rats, there was a downregulation of Nrf2 mRNA expression along with a significant reduction in the enzymatic activity of SOD, CAT, GR, and GPx. Lyc treatment was able to successfully reverse HFD-mediated changes as compared to the HFD group. Consuming lyc helps to prevent fat and renal damage in a positive way.
C1 [Robert, Asirvatham Alwin] Prince Sultan Mil Med City, Dept Endocrinol & Diabet, Riyadh 11159, Saudi Arabia.
   [Albrahim, Tarfa] Princess Nourah bint Abdulrahman Univ, Coll Hlth & Rehabil Sci, Dept Hlth Sci, Clin Nutr, Riyadh 11564, Saudi Arabia.
C3 Prince Sultan Military Medical City; Princess Nourah bint Abdulrahman
   University
RP Albrahim, T (corresponding author), Princess Nourah bint Abdulrahman Univ, Coll Hlth & Rehabil Sci, Dept Hlth Sci, Clin Nutr, Riyadh 11564, Saudi Arabia.
EM tarfa.ibrahim21@gmail.com
OI Albrahim, Tarfa/0000-0003-4360-8115
FU Princess Nourah Bint Abdulrahman University, Princess Nourah Bint
   Abdulrahman University, Riyadh, Saudi Arabia [PNURS2022R69]; Princess
   Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia
FX This research was funded by Princess Nourah Bint Abdulrah-man University
   Research Supporting Project number (PNURS2022R69) , Princess Nourah Bint
   Abdulrahman University, Riyadh, Saudi Arabia.
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NR 56
TC 12
Z9 13
U1 1
U2 7
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 2470-1343
J9 ACS OMEGA
JI ACS Omega
PD SEP 6
PY 2022
VL 7
IS 35
BP 30930
EP 30938
DI 10.1021/acsomega.2c02796
EA AUG 2022
PG 9
WC Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry
GA 4L7JP
UT WOS:000848514700001
PM 36092554
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Zhang, Y
   Li, JW
   Chen, LH
   Liang, R
   Liu, Q
   Wang, ZY
AF Zhang, Yang
   Li, Jinwei
   Chen, Lihua
   Liang, Rui
   Liu, Quan
   Wang, Zhiyi
TI Identification of co-diagnostic effect genes for aortic dissection and
   metabolic syndrome by multiple machine learning algorithms
SO SCIENTIFIC REPORTS
LA English
DT Article
ID MUSCLE-CELL PHENOTYPE; EXPRESSION; CONTRACTILITY; INFLAMMATION;
   PROGENITOR; ANEURYSMS; STRESS; GEO
AB Aortic dissection (AD) is a life-threatening condition in which the inner layer of the aorta tears. It has been reported that metabolic syndrome (MS) has a close linkage with aortic dissection. However, the inter-relational mechanisms between them were still unclear. This article explored the hub gene signatures and potential molecular mechanisms in AD and MS. We obtained five bulk RNA-seq datasets of AD, one single cell RNA-seq (scRNA-seq) dataset of ascending thoracic aortic aneurysm (ATAA), and one bulk RNA-seq dataset of MS from the gene expression omnibus (GEO) database. Identification of differentially expressed genes (DEGs) and key modules via weighted gene co-expression network analysis (WGCNA), functional enrichment analysis, and machine learning algorithms (Random Forest and LASSO regression) were used to identify hub genes for diagnosing AD with MS. XGBoost further improved the diagnostic performance of the model. The receiver operating characteristic (ROC) and precision-recall (PR) curves were developed to assess the diagnostic value. Then, immune cell infiltration and metabolism-associated pathways analyses were created to investigate immune cell and metabolism-associated pathway dysregulation in AD and MS. Finally, the scRNA-seq dataset was performed to confirm the expression levels of identified hub genes. 406 common DEGs were identified between the merged AD and MS datasets. Functional enrichment analysis revealed these DEGs were enriched for applicable terms of metabolism, cellular processes, organismal systems, and human diseases. Besides, the positively related key modules of AD and MS were mainly enriched in transcription factor binding and inflammatory response. In contrast, the negatively related modules were significantly associated with adaptive immune response and regulation of nuclease activity. Through machine learning, nine genes with common diagnostic effects were found in AD and MS, including MAD2L2, IMP4, PRPF4, CHSY1, SLC20A1, SLC9A1, TIPRL, DPYD, and MAPKAPK2. In the training set, the AUC of the hub gene on RP and RR curves was 1. In the AD verification set, the AUC of the Hub gene on RP and RR curves were 0.946 and 0.955, respectively. In the MS set, the AUC of the Hub gene on RP and RR curves were 0.978 and 0.98, respectively. scRNA-seq analysis revealed that the SLC20A1 was found to be relevant in fatty acid metabolic pathways and expressed in endothelial cells. Our study revealed the common pathogenesis of AD and MS. These common pathways and hub genes might provide new ideas for further mechanism research.
C1 [Zhang, Yang] Kunming Med Univ, Kunming 650000, Yunnan, Peoples R China.
   [Zhang, Yang] Kunming Med Univ, Fuwai Yunnan Cardiovasc Hosp, Dept Vasc Surg, Affiliated Cardiovasc Hosp, Kunming 650000, Yunnan, Peoples R China.
   [Li, Jinwei; Liu, Quan] Guangxi Med Univ, Dept Neurosurg, Affiliated Hosp 4, Liuzhou 545000, Guangxi, Peoples R China.
   [Li, Jinwei] Sichuan Univ, West China Hosp, Dept Neurosurg, Chengdu 610000, Sichuan, Peoples R China.
   [Chen, Lihua] Chongqing Med Univ, Dept Cardiol, Affiliated Hosp 2, Chongqing 400010, Peoples R China.
   [Liang, Rui] Chongqing Univ, Coll Bioengn, Chongqing 400030, Peoples R China.
   [Wang, Zhiyi] Dali Univ, Vasc Surg, Affiliated Hosp 1, Dali 671000, Peoples R China.
C3 Kunming Medical University; Kunming Medical University; Guangxi Medical
   University; Sichuan University; Chongqing Medical University; Chongqing
   University; Dali University
RP Wang, ZY (corresponding author), Dali Univ, Vasc Surg, Affiliated Hosp 1, Dali 671000, Peoples R China.
EM 360519215@qq.com
RI chen, lihua/KQU-9125-2024
OI li, Jinwei/0000-0002-4599-995X; Zhang, Yang/0000-0001-9870-8143
FU Liuzhou City's Top Ten Hundred Talents Project; Yunnan Provincial
   Department of Science and Technology Project: Joint Special Project of
   Local Colleges and Universities [202001BA070001019]; Liuzhou Science and
   Technology Plan Projects [2021CBC0121, 2021CBC0128]
FX This study was supported by Liuzhou City's Top Ten Hundred Talents
   Project, The Yunnan Provincial Department of Science and Technology
   Project: Joint Special Project of Local Colleges and Universities
   (202001BA070001019), and Liuzhou Science and Technology Plan Projects
   (2021CBC0121, 2021CBC0128).
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NR 59
TC 0
Z9 0
U1 1
U2 6
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD SEP 8
PY 2023
VL 13
IS 1
AR 14794
DI 10.1038/s41598-023-41017-4
PG 13
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA R5DF9
UT WOS:001064547300031
PM 37684281
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Viswanad, B
   Srinivasan, K
   Kaul, CL
   Ramarao, P
AF Viswanad, B
   Srinivasan, K
   Kaul, CL
   Ramarao, P
TI Effect of tempol on altered angiotensin II and acetylcholine-mediated
   vascular responses in thoracic aorta isolated from rats with insulin
   resistance
SO PHARMACOLOGICAL RESEARCH
LA English
DT Article
DE angiotensin II; insulin resistance; superoxide; acetylcholine; high fat
   diet; thoracic aorta
ID HIGH-FAT; NITRIC-OXIDE; ENDOTHELIAL DYSFUNCTION; BLOOD-PRESSURE; INDUCED
   HYPERTENSION; OXIDATIVE STRESS; AT(1) RECEPTORS; DIET; PIOGLITAZONE;
   RELAXATION
AB The altered vascular responses to various vasopressors and relaxants have been well reported in various animal models of hypertension, insulin resistance and diabetes. Though the role of oxidative stress (increased superoxide levels) associated with these altered vascular responses in hyperglycemic/diabetic state is well documented, the role of the same remains to be largely unknown in vascular dysfunction coupled with prediabetic insulin resistant state. The objective of the present study was therefore to elucidate the role of free radicals particularly superoxides if any associated with vascular dysfunction in diet-induced insulin resistance of rats. In this regard, the effect of tempol (a membrane permeable superoxide dismutase mimetic/free radical scavenger) on the enhanced Ang II-induced contraction and impaired-ACh mediated relaxation in thoracic aorta of rats with insulin resistance was studied. Ang II-induced contraction and ACh-mediated relaxation responses were recorded isometrically in endothelium intact and denuded thoracic aortic ring preparations isolated front male Sprague-Dawley rats which were fed with either normal pellet diet (NPD) (control group) or high fat diet (HFD) (insulin resistant group) for 4 weeks. The HFD-fed rats exhibited characteristic features of insulin resistance syndrome viz., obesity, hyperinsulinaemia, mild hyperglycemia, hypertriglyceridemia, hypercholesterolemia, glucose intolerance and hypertension. Maximal contractile response (E-max) to Ang II was increased in endothelium intact aortic ring preparations obtained from HFD-fed rats as compared to NPD-fed control rats. Denudation of endothelium significantly increased Ang II-mediated E-max responses in thoracic aortic rings of NPD-fed rats, whereas it produced only minimal alteration to the E-max in the HFD-fed rats. In addition, ACh-mediated relaxation response was impaired in endothelium intact aortic rings isolated from HFD-fed rats. Tempol (30-300 mu M) significantly and dose dependently inhibited enhanced vascular responses (E-max) of Ang II in endothelium intact, but not in endothelium denuded aortic ring preparations. Tempol (30 mu M) reversed the impaired acetylcholine (ACh)-mediated relaxations in endothelium intact aortic ring preparations of HFD-fed rats. Endothelium independent vasorelaxations (EIV) to sodium nitroprusside (SNP) were similar for both NPD and HFD. In conclusion, our results indicate that superoxide radicals play crucial role in enhanced contractile and impaired vasodilatory responses to Ang II and ACh, respectively, in thoracic aortic rings isolated from diet-induced insulin resistant rats. (c) 2005 Elsevier Ltd. All rights reserved.
C1 Natl Inst Pharmaceut Educ & Res, Dept Pharm & Toxicol, Nagar 160062, Punjab, India.
C3 National Institute of Pharmaceutical Education & Research, S.A.S. Nagar
   (Mohali)
RP Natl Inst Pharmaceut Educ & Res, Dept Pharm & Toxicol, Phase X Sector 67, Nagar 160062, Punjab, India.
EM ramaraop@yahoo.com
RI poduri, ramarao/R-3004-2019
OI Krishnamoorthy, Srinivasan/0000-0003-2435-1561
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NR 46
TC 41
Z9 43
U1 0
U2 5
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 1043-6618
J9 PHARMACOL RES
JI Pharmacol. Res.
PD MAR
PY 2006
VL 53
IS 3
BP 209
EP 215
DI 10.1016/j.phrs.2005.11.002
PG 7
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 022RG
UT WOS:000236072800003
PM 16412660
DA 2025-06-11
ER

PT J
AU Xu, SM
   Xue, Y
AF Xu, Shumei
   Xue, Ying
TI Pediatric obesity: Causes, symptoms, prevention and treatment (Review)
SO EXPERIMENTAL AND THERAPEUTIC MEDICINE
LA English
DT Article; Proceedings Paper
CT Paediatric Virology Workshop
CY OCT 10-10, 2015
CL Athens, GREECE
DE pediatric obesity; nutritional disorder; insulin resistance; type 2
   diabetes; hypertension; hyperlipidemia
ID INSULIN-RESISTANCE SYNDROME; BODY-MASS INDEX; CHILDHOOD OBESITY;
   RISK-FACTORS; GLUCOSE-TOLERANCE; AMERICAN CHILDREN; ADOLESCENTS; HEALTH;
   ATHEROSCLEROSIS; ASSOCIATIONS
AB Pediatric or childhood obesity is the most prevalent nutritional disorder among children and adolescents worldwide. Approximately 43 million individuals are obese, 21-24% children and adolescents are overweight, and 16-18% of individuals have abdominal obesity. The prevalence of obesity is highest among specific ethnic groups. Obesity increases the risk of heart diseases in children and adults. Childhood obesity predisposes the individual to insulin resistance and type 2 diabetes, hypertension, hyperlipidemia, liver and kidney diseases and causes reproductive dysfunction in adults. Obesity in children is a major health concern of the developed world. The National Health and Nutrition Examination Survey has reported that the prevalence of obesity is on the increase in all the pediatric age groups, in males and females, and in various ethnic and racial groups. Factors, such as eating habits, genetics, environment, metabolism, and lifestyle play an important role in the development of obesity. Over 90% of obesity cases are idiopathic and less than 10% are associated with genetic and hormonal causes. Obesity occurs when the body consumes more calories than it burns, through overeating and underexercising. The symptoms of obesity include breathing disorders, sleep apnea, chronic obstructive pulmonary disease, certain types of cancer such as prostate, bowel, breast and uterine, coronary heart disease, diabetes (type 2 in children), depression, liver and gallbladder problems, gastro-esophageal reflux disease, high blood pressure, high cholesterol, stroke, and joint diseases such as osteoarthritis, pain in knees and lower back. Environmental, behavioral such as consumption of convenience foods, genetic, and family factors contribute to pediatric obesity. Obesity can be countered through lower calorie consumption, weight loss and diet programs, as well as increased physical activity. A number of endogenous molecules including leptin, hypothalamic melanocortin 4 receptor, and mitochondrial uncoupling proteins, are known to affect body weight. These molecules serve as potential targets for the pharmacological manipulation of obesity. Sibutramine and orlistat are primariliy used for the treatment of adult obesity, which produces modest weight loss, of 3-8% compared to placebo. For children and obese adolescents, metformin is used in the case of insulin resistance and hyperinsulinemia. Octreotide is used for hypothalamic obesity. Bariatric surgery is performed for the treatment of severe childhood obesity. The causes, symptoms, prevention and treatment of pediatric obesity are described in the present review.
C1 [Xu, Shumei; Xue, Ying] Xuzhou Childrens Hosp, Dept Endocrinol, Xuzhou 221002, Jiangsu, Peoples R China.
RP Xue, Y (corresponding author), Xuzhou Childrens Hosp, Dept Endocrinol, 18 Sudibei Rd, Xuzhou 221002, Jiangsu, Peoples R China.
EM xueying96@yeah.net
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NR 41
TC 115
Z9 155
U1 1
U2 123
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1792-0981
EI 1792-1015
J9 EXP THER MED
JI Exp. Ther. Med.
PD JAN
PY 2016
VL 11
IS 1
BP 15
EP 20
DI 10.3892/etm.2015.2853
PG 6
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Research & Experimental Medicine
GA CZ1VB
UT WOS:000366892600003
PM 26834850
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Barazesh, M
   Jalili, S
   Akhzari, M
   Faraji, F
   Khorramdin, E
AF Barazesh, Mahdi
   Jalili, Sajad
   Akhzari, Morteza
   Faraji, Fouzieyeh
   Khorramdin, Ebrahim
TI Recent Progresses on Pathophysiology, Diagnosis, Therapeutic Modalities,
   and Management of Non-alcoholic Fatty Liver Disorder
SO CURRENT DRUG THERAPY
LA English
DT Review
DE Dyslipidemia; hepatocellular fibrosis; insulin resistance; liver
   transplant; metabolic syndrome; NAFLD
ID GUT MICROBIOTA DYSBIOSIS; RADIATION FORCE IMPULSE; INSULIN-RESISTANCE;
   BARIATRIC SURGERY; PHYSICAL-ACTIVITY; NONINVASIVE METHODS; PRACTICAL
   APPROACH; OXIDATIVE STRESS; DISEASE PATIENTS; VITAMIN-E
AB Non-alcoholic fatty liver disease (NAFLD) is currently the utmost common chronic liver disorder that happens through all age groups and is identified to occur in 14%-30% of the general population, demonstrating a critical and grossing clinical issue because of the growing incidence of obesity and overweight. From the histological aspect, it looks like alcoholic liver damage, but it happens in patients who avoid remarkable alcohol usage. NAFLD comprises a broad spectrum, ranging from benign hepatocellular steatosis to inflammatory nonalcoholic steatohepatitis (NASH), different levels of fibrosis, and cirrhosis. Patients with NASH are more susceptible to more rapid progression to cirrhosis and hepatocellular carcinoma. There is no single factor that drives proceeding from simple steatosis to NASH. However, a combination of multi parameters such as genetic background, gut microflora, intake of high fat/ fructose dietary contents or methionine/choline-deficient diet, and consequently accumulated hepatocellular lipids mainly including triglycerides and also other bio-analytes, such as free fatty acids, cholesterol, and phospholipids display a crucial role in disease promotion. NAFLD is related to overweight and insulin resistance (IR) and is regarded as the hepatic presentation of the metabolic syndrome, an amalgamation of medical statuses such as hyperlipidemia, hypertension, type 2 diabetes, and visceral obesity. Despite the increasing prevalence of this disease, which imposes a remarkable clinical burden, most affected patients remain undiagnosed in a timely manner, largely related to the asymptomatic entity of NAFLD patients and the unavailability of accurate and efficient noninvasive diagnostic tests. However, liver biopsy is considered a gold standard for NAFLD diagnosis, but due to being expensive and invasiveness is inappropriate for periodic disease screening. Some noninvasive monitoring approaches have been established recently for NAFLD assessment. In addition to the problem of correct disease course prediction, no effective therapeutic modalities are approved for disease treatment. Imaging techniques can commonly validate the screening and discrimination of NAFLD; nevertheless, staging the disease needs a liver biopsy. The present therapeutic approaches depend on weight loss, sports activities, and dietary modifications, although different insulin-sensitizing drugs, antioxidants, and therapeutic agents seem hopeful. This review aims to focus on the current knowledge concerning epidemiology, pathogenesis, and different biochemical experiments and imaging modalities applied to diagnose the different grades of NAFLD and its management, as well as new data about pharmacological therapies for this disorder.Lipid metabolism
C1 [Barazesh, Mahdi; Faraji, Fouzieyeh] Gerash Univ Med Sci, Sch Paramed, Gerash, Iran.
   [Jalili, Sajad; Khorramdin, Ebrahim] Ahvaz Jundishapour Univ Med Sci, Sch Med, Dept Orthoped, Ahvaz, Iran.
   [Akhzari, Morteza] Larestan Univ Med Sci, Sch Nursing, Larestan, Iran.
   [Jalili, Sajad] Ahvaz Jundishapour Univ Med Sci, Dept Orthoped, Ahvaz, Iran.
C3 Ahvaz Jundishapur University of Medical Sciences (AJUMS); Ahvaz
   Jundishapur University of Medical Sciences (AJUMS)
RP Barazesh, M (corresponding author), Gerash Univ Med Sci, Sch Paramed, Gerash, Iran.; Jalili, S (corresponding author), Ahvaz Jundishapour Univ Med Sci, Dept Orthoped, Ahvaz, Iran.
EM barazeshmahdi@yahoo.com; sajadjalili66@gmail.com
RI Jalili, Sajad/KIL-3818-2024
OI Jalili, Sajad/0009-0008-2856-0284
FU Declared none.
FX Declared none.
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NR 282
TC 2
Z9 2
U1 1
U2 14
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1574-8855
EI 2212-3903
J9 CURR DRUG THER
JI Curr. Drug Ther.
PY 2024
VL 19
IS 1
BP 20
EP 48
DI 10.2174/1574885518666230417111247
PG 29
WC Pharmacology & Pharmacy
WE Emerging Sources Citation Index (ESCI)
SC Pharmacology & Pharmacy
GA W4MH5
UT WOS:001091376700003
DA 2025-06-11
ER

PT J
AU Goodrich, DE
   Klingaman, EA
   Verchinina, L
   Goldberg, RW
   Littman, AJ
   Janney, CA
   Kim, HM
   Maguen, S
   Hoerster, KD
   Owen, RR
   Holleman, RG
   Roman, P
   Lai, ZS
   Bowersox, NW
AF Goodrich, David E.
   Klingaman, Elizabeth A.
   Verchinina, Lilia
   Goldberg, Richard W.
   Littman, Alyson J.
   Janney, Carol A.
   Kim, Hyungjin Myra
   Maguen, Shira
   Hoerster, Katherine D.
   Owen, Richard R.
   Holleman, Robert G.
   Roman, Pia
   Lai, Zongshan
   Bowersox, Nicholas W.
TI Sex Differences in Weight Loss among Veterans with Serious Mental
   Illness: Observational Study of a National Weight Management Program
SO WOMENS HEALTH ISSUES
LA English
DT Article
ID POSTTRAUMATIC-STRESS-DISORDER; LIFE-STYLE INTERVENTIONS; BODY-MASS
   INDEX; BIPOLAR DISORDER; HEALTH-CARE; RISK-FACTORS; CARDIOMETABOLIC
   RISK; CARDIOVASCULAR RISK; GENDER-DIFFERENCES; OBESITY
AB Purpose: Obesity disproportionately burdens individuals with serious mental illness (SMI), especially women. This observational study investigated whether there were sex differences in weight loss and program participation among veterans with SMI enrolled in the Veterans Health Administration's (VHA) MOVE! weight management program.
   Procedures: Participants were identified from a national cohort of 148,254 veterans enrolled in MOVE! during fiscal years 2008 through 2012 who attended two or more sessions within 12 months of enrollment. The cohort included those with International Classification of Disease, 9th Edition, Clinical Modification (ICD-9-CM) diagnoses for SMI, age less than 70 years, and weight data at baseline and one or more follow-up timepoints within approximately 1 year of enrollment (n = 8,943 men; n = 2,245 women). Linear mixed models assessed associations of sex with 6-and 12-month weight change from baseline, adjusting for demographic-and site-level variables.
   Findings: Both sexes averaged 6.4 (standard deviation, 4.6) sessions within 12 months; however, women with and without SMI participated at rates double their respective proportion rates among all VHA users. Participants averaged statistically significant weight loss at 6 months (men, -2.5 lb [95% CI, - 2.8 to -2.1]; women, -2.4 lb [95% CI, -3.1 to -1.7]) and 12 months (men, -2.5 lb [95% CI, -2.8 to -2.2]; women, -2.9 lb [95% CI, -3.6 to -2.2]), but no sex-based difference in absolute weight loss at either timepoint. Slightly more women achieved 5% or greater (clinically significant) weight loss at the 12-month follow-up than did men (25.7% vs. 23.0%; p < .05).
   Conclusions: Women with SMI participated in MOVE! at rates equivalent to or greater than men with SMI, with comparable weight loss. More women were Black, single, had bipolar and posttraumatic stress disorder, and higher service-connected disability, suggesting areas for program customization. Published by Elsevier Inc. on behalf of Jacobs Institute of Women's Health. Published by Elsevier Inc. on behalf of Jacobs Institute of Women's Health.
C1 [Goodrich, David E.; Verchinina, Lilia; Janney, Carol A.; Kim, Hyungjin Myra; Holleman, Robert G.; Roman, Pia; Lai, Zongshan; Bowersox, Nicholas W.] VA Ann Arbor Healthcare Syst, VA Ctr Clin Management Res, Ann Arbor, MI USA.
   [Klingaman, Elizabeth A.; Goldberg, Richard W.] VA Maryland Hlth Care Syst, Baltimore VA Med Ctr, 10 North Greene St,Annex Suite 720, Baltimore, MD 21201 USA.
   [Klingaman, Elizabeth A.; Goldberg, Richard W.] Univ Maryland, Sch Med, Div Psychiat Serv Res, Dept Psychiat, Baltimore, MD USA.
   [Littman, Alyson J.] VA Puget Sound Med Ctr, Epidemiol Res & Informat Ctr, Seattle, WA USA.
   [Littman, Alyson J.] Univ Washington, Dept Epidemiol, Seattle, WA USA.
   [Kim, Hyungjin Myra] Univ Michigan, Ctr Stat Consultat & Res, Ann Arbor, MI USA.
   [Maguen, Shira] San Francisco VA Med Ctr, San Francisco, CA USA.
   [Maguen, Shira] Univ Calif San Francisco, Dept Psychiat, San Francisco, CA 94143 USA.
   [Hoerster, Katherine D.] VA Puget Sound Healthcare Syst, Mental Hlth Serv, Seattle, WA USA.
   [Hoerster, Katherine D.] Univ Washington, Dept Psychiat & Behav Sci, Seattle, WA 98195 USA.
   [Owen, Richard R.] Cent Arkansas Vet Healthcare Syst, VA Ctr Mental Healthcare & Outcomes Res, North Little Rock, AR USA.
   [Owen, Richard R.] Univ Arkansas Med Sci, Coll Med, Dept Psychiat, Inst Psychiat Res, Little Rock, AR 72205 USA.
   [Bowersox, Nicholas W.] VA Serious Mental Illness Treatment Resource & Ev, Ann Arbor, MI USA.
C3 US Department of Veterans Affairs; Veterans Health Administration (VHA);
   VA Ann Arbor Healthcare System; US Department of Veterans Affairs;
   Veterans Health Administration (VHA); Baltimore VA Medical Center;
   University System of Maryland; University of Maryland Baltimore;
   University of Washington; University of Washington Seattle; University
   of Michigan System; University of Michigan; US Department of Veterans
   Affairs; Veterans Health Administration (VHA); San Francisco VA Medical
   Center; University of California System; University of California San
   Francisco; US Department of Veterans Affairs; Veterans Health
   Administration (VHA); Vet Affairs Puget Sound Health Care System;
   University of Washington; University of Washington Seattle; US
   Department of Veterans Affairs; Veterans Health Administration (VHA);
   Central Arkansas Veterans Healthcare System; University of Arkansas
   System; University of Arkansas Medical Sciences
RP Klingaman, EA (corresponding author), VA Maryland Hlth Care Syst, Baltimore VA Med Ctr, 10 North Greene St,Annex Suite 720, Baltimore, MD 21201 USA.
EM Elizabeth.klingaman@va.gov
RI Owen, Richard/HTM-1385-2023
OI Bowersox, Nicholas/0000-0001-9867-4326; Goodrich,
   David/0000-0003-3232-2189; Janney, Carol/0000-0002-4821-4679
FU VA Health Services Research and Development Quality Enhancement Research
   Initiative (QUERI) programs for Diabetes and Mental Health research as a
   locally initiated project [QLP 55-017]; Department of Veterans Affairs
   Office of Academic Affiliations Advanced Fellowship Program in Mental
   Illness Research and Treatment; VA Rehabilitation R&D Career Development
   Award [6982]
FX Funding was provided by the VA Health Services Research and Development
   Quality Enhancement Research Initiative (QUERI) programs for Diabetes
   and Mental Health research as a locally initiated project (QLP 55-017).
   Dr. Klingaman's time was supported by the Department of Veterans Affairs
   Office of Academic Affiliations Advanced Fellowship Program in Mental
   Illness Research and Treatment and is the result of work supported with
   resources and the use of facilities at the VA Capitol Health Care
   Network (VISN 5) Mental Illness Research, Education, and Clinical Center
   (MIRECC). Dr. Littman's time was supported by a VA Rehabilitation R&D
   Career Development Award (#6982).
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NR 74
TC 8
Z9 10
U1 0
U2 6
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1049-3867
EI 1878-4321
J9 WOMEN HEALTH ISS
JI Womens Health Iss.
PD JUL-AUG
PY 2016
VL 26
IS 4
BP 410
EP 419
DI 10.1016/j.whi.2016.05.001
PG 10
WC Public, Environmental & Occupational Health; Women's Studies
WE Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; Women's Studies
GA DS4KB
UT WOS:000380748900008
PM 27365284
DA 2025-06-11
ER

PT J
AU Halmos, T
   Suba, I
AF Halmos, Tamas
   Suba, Ilona
TI Role of endocrinological factors and metabolic processes in regulating
   life-span
SO ORVOSI HETILAP
LA English
DT Article
DE insulin resistance; insulin-like growth factors; mitohormesis; mTOR;
   metformin; calorie restriction
ID DEVELOPMENTAL ORIGINS; INSULIN SENSITIVITY; GROWTH; MITOHORMESIS;
   METFORMIN; LONGEVITY; HEALTH; MTOR; AXIS
AB People want to live as long as possible in good health. If we eliminate the unfavorable external conditions, the life expectancy could exceed 100 years. In the 20th and 21th centuries, life expectancy in welfare societies increased significantly, including in Hungary. Based on the reviewed literature, we examined what endocrinological and metabolic factors play a role in prolonging life in addition to genetics and inheritance. We examined all endogenous factors that can positively or negatively affect age-related diseases (Alzheimer's disease, cardiovascular disease, cancer) and longevity. We highlighted the aging effects of hyperinsulinemia, insulin resistance, metabolic syndrome, the controversial role of insulin-like growth factor-1, and more recently discovered peptides involved in prolonging lifespan, such as klotho and humanin. We described the role of mitochondria in determining longevity, we demonstrated the process of mitohormesis and its stress-protective function. We presented the target organ of rapamycin, mTOR, the inhibition of which prolongs lifespan, as well as sirtuins. We covered the process of autophagy and described the role of senolytics in aging. The decrease in autoimmunity in old age contributes to the shortening of life expectancy, we referred to the coordinating role of the thymus. We highlighted the important role of intestinal microbiome in the regulation of longevity. We referred to human data obtained from observations on "centenarians". We examined what intervention options are available to prolong healthy life expectancy. Among the lifestyle options, we highlighted the beneficial role of calorie reduction and exercise. We examined the putative beneficial effects of some drugs. These include metformin, acarbose, resveratrol. The effect of each of these drugs is similar to calorie restriction. There is no "miracle cure" that has been shown to prolong life-span in humans. Some genes and gene mutations have beneficial effects, but this can be modified by environmental factors, diseases, accidents, and other external harms. We highlight the accelerating effects of obesity, low-grade inflammation, and insulin resistance on aging. Due to the prevalence of metabolic syndrome, this poses a significant risk to public health. The assessment of the effects of insulin, growth hormone, and insulin-like growth factors remains controversial. A healthy, mentally and physically active lifestyle, calorie reduction is definitely beneficial. The evaluation of life-prolonging agents is still controversial.
C1 [Halmos, Tamas] Metabolikus Ambulancia, MAZSIHISZ Szeretetkorhaz, Budapest, Hungary.
   [Suba, Ilona] Tudogondozo Int, Bajcsy Zsilinszky Korhaz Rendeloint, Budapest, Hungary.
RP Halmos, T (corresponding author), Kikelet U 43-b, H-1125 Budapest, Hungary.
EM fishwash@t-online.hu; suba.ilona@gmail.com
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NR 64
TC 2
Z9 2
U1 0
U2 9
PU AKADEMIAI KIADO ZRT
PI BUDAPEST
PA BUDAFOKI UT 187-189-A-3, H-1117 BUDAPEST, HUNGARY
SN 0030-6002
EI 1788-6120
J9 ORVOSI HETILAP
JI Orvosi Hetilap
PD AUG
PY 2021
VL 162
IS 33
BP 1318
EP 1327
DI 10.1556/650.2021.32200
PG 10
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA UB8XN
UT WOS:000686122200002
PM 34392236
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Nakagawa, H
   Tstunooka, N
   Yamamoto, Y
   Yoshida, M
   Nakata, T
   Kawachi, K
AF Nakagawa, Hiromichi
   Tstunooka, Nobuo
   Yamamoto, Yuji
   Yoshida, Motohira
   Nakata, Tatsuhiro
   Kawachi, Kanji
TI Intestinal ischemia/reperfusion-induced bacterial translocation and lung
   injury in atherosclerotic rats with hypoadiponectinemia
SO SURGERY
LA English
DT Article
ID NITRIC-OXIDE SYNTHASE; ISCHEMIA-REPERFUSION INJURY; DIAMINE OXIDASE;
   METABOLIC SYNDROME; ENDOTHELIAL-CELLS; OXIDATIVE STRESS; ADIPONECTIN;
   INFLAMMATION; PROTECTS; ADHESION
AB Background. Intestinal ischemia/reperfusion causes intestinal mucosal injury, which may result in bacterial translocation (BT) and multiple organ failure. Lung injury is a common complication after intestinal ischemia/reperfusion. Adiponectin is an antiinflammatory adipokine, and it plays an important role in the development of metabolic syndrome in hypoadiponectinemia. In atherosclerosis with hypoadiponectinemia, BT also may aggravate injuries induced by intestinal ischemia/reperfusion.
   Methods. Wistar rats were divided into 3 groups: Normal group (normal diet), Chol group, (2% high cholesterol diet), and Chol+1400W group (Chol group plus 1400W, an inducible nitric oxide [iNOS] inhibitor, at 1 mg/kg intraperitoneally 30 minutes preoperatively). The serum concentrations of lipids and adiponectin and vascular responses were measured. After midline laparotomy (time, T0), the superior mesenteric artery was occluded with a microvascular clamp for 30 minutes, followed by 360 minutes of reperfusion (T1). Intestinal injury was assessed from microcirculatory flow, histology, serum diamine oxidase activity, and permeability. Lung injury was assessed by histology, pulmonary permeability index (PPI), and wet-to-dry lung weight (W/D) ratio. Intestinal and lung nitric oxide (NO) concentrations were also measured. BT was assessed by serum peptidoglycan (PG) concentration.
   Results. The Chol and Chol+1400W groups developed hyperlipidemia and hypoadiponectinemia, the 2 groups also had vascular endothelial dysfunction without histological changes, indicating early atherosclerosis. These groups also showed poor recovery of intestinal microcirculatory flow at T1. The serum diamine oxidase activity, histological intestinal damage, and permeability were elevated, at T1 in the Chol group; however, these findings were not significant in the Normal and Chol+1400W groups. Histological lung damage and lung PPI and W/D ratio were increased. only in the Chol group. Intestinal and lung No concentrations were significantly elevated at T1 in the Chol group. The serum PG concentration was elevated significantly in the Chol group.
   Conclusion. In atherosclerotic rats with hypoadiponectinemia, intestinal microcirculatory flow does not recover adequately after intestinal ischemia/reperfusion because of endothelial dysfunction. Atherosclerosis with hypoadiponectinemia increased the incidence of BT further by aggravating intestinal mucosal injury and, moreover, it aggravated lung injury. Although inhibition of iNOS does not lead to adequate recovery of intestinal microcirculatory flow, it reduces injury by decreasing the amount of NO derived from high enzymatic iNOS activity in the intestine. (Surgery 2009;145:48-56)
C1 [Nakagawa, Hiromichi; Tstunooka, Nobuo; Yamamoto, Yuji; Yoshida, Motohira; Nakata, Tatsuhiro; Kawachi, Kanji] Ehime Univ, Grad Sch Med, Dept Organ Regenerat Surg, Toon, Ehime 7910295, Japan.
C3 Ehime University
RP Nakagawa, H (corresponding author), Ehime Univ, Grad Sch Med, Dept Organ Regenerat Surg, Toon, Ehime 7910295, Japan.
EM hinakaga@m.ehime.u.ac.jp
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NR 41
TC 17
Z9 19
U1 0
U2 8
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0039-6060
J9 SURGERY
JI Surgery
PD JAN
PY 2009
VL 145
IS 1
BP 48
EP 56
DI 10.1016/j.surg.2008.07.018
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 386SX
UT WOS:000261904000009
PM 19081475
DA 2025-06-11
ER

PT J
AU Ayub, M
   Arsalan, A
   Khan, SUDA
   Bajwa, S
   Hussain, F
   Umar, M
   Khizar, B
   Sibtain, M
   Butt, A
   Mukhtar-Ul-Haq, M
   Dogar, IA
   Ansari, MA
   Shafiq, S
   Tariq, M
   Hussain, MI
   Nasar, A
   Mustafa, AB
   Taj, R
   Rehman, RU
   Rajput, AH
   Ambreen, S
   Naqvi, SQEH
   Mehmood, K
   Khan, MY
   Ali, J
   Mehmood, N
   Amir, A
   Nasr, T
   Rabbani, F
   Afridi, A
   Nazar, Z
   Idrees, M
   Chishti, AU
   Khan, RMS
   Khan, A
   Aslam, R
   Mehdi, M
   Asif, A
   Zulqarnain, A
   Afridi, J
   Hussain, A
   Anwar, S
   Salman, S
   Khan, I
   ul Mabood, Z
   Hamzalah, H
   Javed, A
   Nawaz, K
   Zahra, K
   Nayyar, U
   Tooba, S
   Rajput, AA
   Anjum, A
   Rehman, A
   Kanwal, M
   Yasmeen, T
   Hassan, S
   Zaidi, MA
   Nayab, DE
   Kamal, M
   Jamil, B
   Malik, R
   Ul Haq, I
   Bibi, Z
   Nawaz, K
   Anwer, M
   Javed, A
   Rana, NH
   Khan, MNS
   Naeem, F
   Pato, CN
   Pato, MT
   Farooq, S
   Knowles, JA
AF Ayub, Muhammad
   Arsalan, Arsalan
   Khan, Shams-ud-Din Ahmad
   Bajwa, Saqib
   Hussain, Fahad
   Umar, Muhammad
   Khizar, Bakht
   Sibtain, Muhammad
   Butt, Ayesha
   Mukhtar-Ul-Haq, Mian
   Dogar, Imtiaz Ahmad
   Ansari, Moin Ahmad
   Shafiq, Sadia
   Tariq, Muhammad
   Hussain, Mian Iftikhar
   Nasar, Amina
   Mustafa, Ali Burhan
   Taj, Rizwan
   Rehman, Raza Ur
   Rajput, Atir Hanif
   Ambreen, Syeda
   Naqvi, Syed Qalb-e-Hyder
   Mehmood, Khalid
   Khan, Muhammad Younis
   Ali, Jawad
   Mehmood, Nasir
   Amir, Ammara
   Nasr, Tanveer
   Rabbani, Fazal
   Afridi, Adil
   Nazar, Zahid
   Idrees, Muhammad
   Chishti, Ahsan Ul Haq
   Khan, Rana Muzammil Shamsher
   Khan, Anisuzzaman
   Aslam, Rubina
   Mehdi, Muntazir
   Asif, Aftab
   Zulqarnain, Ali
   Afridi, Jalil
   Hussain, Asif
   Anwar, Sibtain
   Salman, Saad
   Khan, Inzemam
   ul Mabood, Zia
   Hamzalah, Hamzalah
   Javed, Adan
   Nawaz, Komal
   Zahra, Kainat
   Nayyar, Urooj
   Tooba, Syeda
   Rajput, Ammara Ali
   Anjum, Anum
   Rehman, Ayesha
   Kanwal, Maria
   Yasmeen, Tahira
   Hassan, Sadia
   Zaidi, Mariyam Ali
   Nayab, Dur E.
   Kamal, Muhammad
   Jamil, Bisma
   Malik, Rida
   Ul Haq, Ihtisham
   Bibi, Zohra
   Nawaz, Kalsoom
   Anwer, Munaza
   Javed, Afzal
   Rana, Nusrat Habib
   Khan, Muhammad Nasar Sayeed
   Naeem, Farooq
   Pato, Carlos N.
   Pato, Michele T.
   Farooq, Saeed
   Knowles, James A.
TI Self-reported health and smoking status, and body mass index: a
   case-control comparison based on GEN SCRIP (GENetics of SChizophRenia In
   Pakistan) data
SO BMJ OPEN
LA English
DT Article
DE schizophrenia &amp; psychotic disorders; public health; mental health
ID SEVERE MENTAL-ILLNESS; GENERAL MEDICAL-SERVICES; METABOLIC SYNDROME;
   EXCESS MORTALITY; PHYSICAL HEALTH; PRIMARY-CARE; RISK-FACTORS;
   PREVALENCE; PEOPLE; DISORDERS
AB Introduction Individuals with schizophrenia are at a high risk of physical health comorbidities and premature mortality. Cardiovascular and metabolic causes are an important contributor. There are gaps in monitoring, documenting and managing these physical health comorbidities. Because of their condition, patients themselves may not be aware of these comorbidities and may not be able to follow a lifestyle that prevents and manages the complications. In many low-income and middle-income countries including Pakistan, the bulk of the burden of care for those struggling with schizophrenia falls on the families. Objectives To determine the rate of self-reported physical health disorders and risk factors, like body mass index (BMI) and smoking, associated with cardiovascular and metabolic disorders in cases of schizophrenia compared with a group of mentally healthy controls. Design A case-controlled, cross-sectional multicentre study of patients with schizophrenia in Pakistan. Settings Multiple data collection sites across the country for patients, that is, public and private psychiatric OPDs (out patient departments), specialised psychiatric care facilities, and psychiatric wards of teaching and district level hospitals. Healthy controls were enrolled from the community. Participants We report a total of 6838 participants' data with (N 3411 (49.9%)) cases of schizophrenia compared with a group of healthy controls (N 3427 (50.1%)). Results BMI (OR 0.98 (CI 0.97 to 0.99), p=0.0025), and the rate of smoking is higher in patients with schizophrenia than in controls. Problems with vision (OR 0.13 (0.08 to 0.2), joint pain (OR 0.18 (0.07 to 0.44)) and high cholesterol (OR 0.13 (0.05 to 0.35)) have higher reported prevalence in controls. The cases describe more physical health disorders in the category 'other' (OR 4.65 (3.01 to 7.18)). This captures residual disorders not listed in the questionnaire. Conclusions Participants with schizophrenia in comparison with controls report more disorders. The access in the 'other' category may be a reflection of undiagnosed disorders.
C1 [Ayub, Muhammad; Nasar, Amina; Khan, Muhammad Nasar Sayeed] Queens Univ, Psychiat, Kingston, ON, Canada.
   [Arsalan, Arsalan] Univ Peshawar, Pharm, Peshawar, Pakistan.
   [Khan, Shams-ud-Din Ahmad] Al Shams Hosp Sargodha, Psychiat, Sargodha, Pakistan.
   [Bajwa, Saqib] Dist Headquarter Hosp Gujranwala, Psychiat, Gujranwala, Pakistan.
   [Hussain, Fahad; Umar, Muhammad; Khizar, Bakht; Sibtain, Muhammad; Butt, Ayesha; Salman, Saad; Khan, Inzemam; ul Mabood, Zia; Hamzalah, Hamzalah; Javed, Adan; Nawaz, Komal; Zahra, Kainat; Nayyar, Urooj; Tooba, Syeda; Rajput, Ammara Ali; Anjum, Anum; Rehman, Ayesha; Kanwal, Maria; Yasmeen, Tahira; Hassan, Sadia; Zaidi, Mariyam Ali; Nayab, Dur E.; Kamal, Muhammad; Jamil, Bisma; Malik, Rida; Ul Haq, Ihtisham; Bibi, Zohra; Nawaz, Kalsoom; Anwer, Munaza; Rana, Nusrat Habib] Lahore Inst Res & Dev, Res, Lahore, Pakistan.
   [Mukhtar-Ul-Haq, Mian; Rabbani, Fazal; Afridi, Adil; Nazar, Zahid] Lady Reading Hosp, Psychiat, Peshawar, Pakistan.
   [Dogar, Imtiaz Ahmad] Dist Head Quarter Hosp, Dept Psychiat, Faisalabad, Pakistan.
   [Ansari, Moin Ahmad; Rajput, Atir Hanif; Ambreen, Syeda; Naqvi, Syed Qalb-e-Hyder] Sir Cowasjee Jehangir Inst Psychiat, Psychiat, Hyderabad, Pakistan.
   [Shafiq, Sadia; Tariq, Muhammad; Afridi, Jalil; Hussain, Asif] Shafique Psychiat Clin, Psychiat, Peshawar, Pakistan.
   [Hussain, Mian Iftikhar] Mian Iftikhar Psychiat Hosp, Psychiat, Peshawar, Pakistan.
   [Mustafa, Ali Burhan] Sheikh Zayed Hosp Rahim Yar Khan, Psychiat, Rahim Yar Khan, Pakistan.
   [Taj, Rizwan] Pakistan Inst Med Sci, Psychiat, Islamabad, Pakistan.
   [Rehman, Raza Ur; Mehmood, Nasir] Karwan E Hayat Psychiat Hosp & Rehabil Ctr, Psychiat & Psychol, Karachi, Pakistan.
   [Mehmood, Khalid] Ar Rahma Hosp, Psychiat, Multan, Pakistan.
   [Khan, Muhammad Younis] Khushal Med Ctr, Psychiat, Peshawar, Pakistan.
   [Ali, Jawad] Govt Mental & Gen Hosp Dadar, Psychiat, Mansehra, Pakistan.
   [Amir, Ammara] Sir Gangaraam Hosp, Psychiat, Lahore, Pakistan.
   [Nasr, Tanveer] Ameena Clin, Psychol, Gujranwala, Pakistan.
   [Idrees, Muhammad] Akbar Med Ctr, Idrees Private Clin, Peshawar, Pakistan.
   [Chishti, Ahsan Ul Haq] Recovery Rehab Ctr, Psychiat, Lahore, Pakistan.
   [Khan, Rana Muzammil Shamsher] Allama Iqbal Teaching Hosp Sialkot, Psychiat, Sialkot, Pakistan.
   [Khan, Anisuzzaman] Nai Zindage Psychiat Hosp, Psychiat, Multan, Pakistan.
   [Aslam, Rubina] Jinnah Hosp, Psychiat, Lahore, Pakistan.
   [Mehdi, Muntazir] Haji Abdul Qayyum Hosp, Psychiat, Sahiwal, Pakistan.
   [Asif, Aftab] Mayo Hosp Lahore, Psychiat, Lahore, Pakistan.
   [Zulqarnain, Ali] Aleeze Neuro Psychiat Ctr, Psychiat, Sargodha, Pakistan.
   [Anwar, Sibtain] Sibtain Anwar Psychiat Hosp, Psychiat, Mardan, Pakistan.
   [Javed, Afzal] Pakistan Psychiat Res Ctr, Mental Hlth, Fountain House, Lahore, Pakistan.
   [Naeem, Farooq] Univ Toronto, Psychiat, Fac Med, Toronto, ON, Canada.
   [Naeem, Farooq] Ctr Addict & Mental Hlth, Psychiat, Toronto, ON, Canada.
   [Pato, Carlos N.; Pato, Michele T.] Suny Downstate Med Ctr, Behav Sci, Brooklyn, NY 11203 USA.
   [Farooq, Saeed] Keele Univ, Psychiat, Keele, Staffs, England.
   [Knowles, James A.] Suny Downstate Med Ctr, Cell Biol, Brooklyn, NY 11203 USA.
C3 Queens University - Canada; University of Peshawar; Pakistan Institute
   of Medical Sciences; University of Toronto; University of Toronto;
   Centre for Addiction & Mental Health - Canada; State University of New
   York (SUNY) System; SUNY Downstate Health Sciences University; Keele
   University; State University of New York (SUNY) System; SUNY Downstate
   Health Sciences University
RP Ayub, M (corresponding author), Queenns Univ, Psychiat, Kingston, ON, Canada.
EM ma84@queensu.ca
RI Yasmeen, Tahira/LXB-0382-2024; Khan, MuhammadNauman/MIK-8465-2025;
   Mustafa, Ali/AAG-4324-2021; ali, jawad/ISU-4118-2023; Bajwa,
   Saqib/IAM-6773-2023; Penninx, Brenda/S-7627-2017; Khan,
   Muhammad/HPG-5333-2023; Ayub, Mahmood/V-8792-2019; Naeem,
   Farooq/M-2310-2019; Tariq, Muhammad/KHZ-0791-2024; Kirov,
   George/AGU-0471-2022; Umar, Muhammad/C-4543-2019; IDREES,
   MUHAMMAD/JLM-2401-2023; Farooq, Saeed/HGT-7232-2022
OI Hassan, Arsalan/0000-0002-3262-0277; Farooq, Saeed/0000-0003-2088-6876;
   Mustafa, Ali Burhan/0009-0005-6498-5173; Ayub,
   Muhammad/0000-0002-7111-1571
FU National Institute of Mental Health [1R01MH112904-01]
FX This work was supported by the 'National Institute of Mental Health'
   (grant number: 1R01MH112904-01).
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NR 69
TC 0
Z9 0
U1 0
U2 3
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2044-6055
J9 BMJ OPEN
JI BMJ Open
PY 2021
VL 11
IS 4
AR e042331
DI 10.1136/bmjopen-2020-042331
PG 9
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA RM0XO
UT WOS:000639385400044
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Ishimori, ML
   Martin, R
   Berman, DS
   Goykhman, P
   Shaw, LJ
   Shufelt, C
   Slomka, PJ
   Thomson, LEJ
   Schapira, J
   Yang, YC
   Wallace, DJ
   Weisman, MH
   Merz, CNB
AF Ishimori, Mariko L.
   Martin, Rebecca
   Berman, Daniel S.
   Goykhman, Pavel
   Shaw, Leslee J.
   Shufelt, Chrisandra
   Slomka, Piotr J.
   Thomson, Louise E. J.
   Schapira, Jay
   Yang, Yuching
   Wallace, Daniel J.
   Weisman, Michael H.
   Merz, C. Noel Bairey
TI Myocardial Ischemia in the Absence of Obstructive Coronary Artery
   Disease in Systemic Lupus Erythematosus
SO JACC-CARDIOVASCULAR IMAGING
LA English
DT Article
DE cardiac magnetic resonance; chest pain; microvascular coronary
   dysfunction; myocardial ischemia; systemic lupus erythematosus
ID CARDIOVASCULAR MAGNETIC-RESONANCE; CARDIAC SYNDROME-X; COMPUTED
   TOMOGRAPHIC ANGIOGRAPHY; MICROVASCULAR DYSFUNCTION; RISK-FACTORS;
   CHEST-PAIN; PERFUSION; STRESS; STENOSES; WOMEN
AB OBJECTIVES The purpose of this study was to evaluate the presence of myocardial ischemia measured by adenosine stress cardiac magnetic resonance (CMR) using visual myocardial perfusion and a quantitative myocardial perfusion reserve index (MPRI) in the absence of obstructive coronary artery disease (CAD) in women with systemic lupus erythematosus (SLE) with anginal chest pain (CP).
   BACKGROUND Ischemic heart disease is a leading cause of morbidity and mortality in SLE. Previous studies demonstrated the presence of perfusion defects using adenosine stress CMR in patients with CP and no obstructive CAD, consistent with microvascular coronary dysfunction in patients without SLE.
   METHOD Twenty female SLE patients with typical and atypical anginal CP were prospectively enrolled. Patients with established cardiovascular disease were excluded. CMR was performed with 0.05 mmol/kg gadolinium adenosine stress first-pass perfusion in SLE patients and in 10 asymptomatic reference control women. SLE patients also underwent 64-slice coronary computed tomography angiography. CMR was scored visually and quantitatively (MPRI).
   RESULTS Among 18 patients with complete data, no patient had obstructive CAD; however, 8 of 18 (44%) displayed visual perfusion defects on stress CMR compared with 0 in 10 control subjects (p = 0.014). The mean MPRI in patients versus controls was 2.0 +/- 0.4 versus 2.4 +/- 0.4 (p = 0.031) in the subepicardium and 1.8 +/- 0.3 versus 2.1 +/- 0.4 (p = 0.24) in the subendocardium. Multivariate linear regression revealed that SLE was the only predictor of subepicardial (p < 0.0025; beta = -1.059) and subendocardial (p < 0.05; beta = -0.529) MPRIs.
   CONCLUSIONS We observed a 44% prevalence of abnormal stress myocardial perfusion by CMR in the absence of obstructive CAD in SLE patients with anginal CP. Compared with controls, reduced MPRI was observed in SLE patients, and SLE presence was a significant predictor of an abnormal MPRI. These findings are consistent with the hypothesis that anginal CP in SLE patients without obstructive CAD is due to myocardial ischemia potentially caused by microvascular coronary dysfunction. Further research in a larger SLE population is warranted. (J Am Coll Cardiol Img 2011;4:27-33) (C) 2011 by the American College of Cardiology Foundation
C1 [Ishimori, Mariko L.; Martin, Rebecca; Wallace, Daniel J.; Weisman, Michael H.] Cedars Sinai Med Ctr, Div Rheumatol, Dept Med, Los Angeles, CA 90048 USA.
   [Berman, Daniel S.; Slomka, Piotr J.; Thomson, Louise E. J.] Cedars Sinai Med Ctr, Dept Imaging, Div Cardiac Imaging, Los Angeles, CA 90048 USA.
   [Goykhman, Pavel; Yang, Yuching; Merz, C. Noel Bairey] Cedars Sinai Med Ctr, Womens Heart Ctr, Cedars Sinai Heart Inst, Los Angeles, CA 90048 USA.
   [Berman, Daniel S.; Slomka, Piotr J.; Thomson, Louise E. J.; Schapira, Jay] Cedars Sinai Med Ctr, Dept Med, Div Cardiol, Los Angeles, CA 90048 USA.
   [Shaw, Leslee J.] Emory Univ, Program Cardiovasc Outcomes Res & Epidemiol, Atlanta, GA 30322 USA.
C3 Cedars Sinai Medical Center; Cedars Sinai Medical Center; Cedars Sinai
   Medical Center; Cedars Sinai Medical Center; Emory University
RP Ishimori, ML (corresponding author), Cedars Sinai Med Ctr, Div Rheumatol, Dept Med, 8700 Beverly Blvd,B-131, Los Angeles, CA 90048 USA.
EM Mariko.Ishimori@cshs.org
RI Ishimori, Mariko/AAI-1401-2021; Shaw, Leslee/ABG-4621-2022; berman,
   daniel/ABF-0670-2022; Wang, Yuhui/JTT-7711-2023; Slomka,
   Piotr/GRX-0855-2022
OI Ishmori, Mariko/0000-0002-0421-8854; Bairey Merz, C.
   Noel/0000-0002-9933-5155; Slomka, Piotr/0000-0002-6110-938X; Shufelt,
   Chrisandra/0000-0001-6886-9210
FU Diane and Gilford Glazer
FX Supported in part by a grant from Diane and Gilford Glazer. No
   extramural funds were involved. Dr. Bairey Merz has consulted for
   Bristol-Myers Squibb; Curtis Green, LLP; Cook, Inc.; Gilead Sciences and
   Axis Healthcare; Comm, LLC (Gilead); Navvis Healthcare (VHA); National
   Heart, Lung, and Blood Institute; Pollock Communications; Practice Point
   Communications; Society for Women's Health Research; Itamar Medical,
   Inc.; Virginia Commonwealth University (McCue Prize); received lecture
   honorarium from Brentwood Country Club; Mayo Foundation for Medical
   Education; Medical Education Speakers Net; Rush-Copley Medical Center;
   SCS Healthcare (CV Therapeutics); St. John's Regional Medical Center,
   Oxnard, California; Tarzana Medical Center; University of Oklahoma
   Health; Washington University of St. Louis; West Hills Hospital;
   Pri-Med-Scienta Healthcare Education; and owns stock in Medtronic and
   Johnson and Johnson. The other authors have reported that they have no
   relationships to disclose. Matthias Friedrich, MD, served as Guest
   Editor for this paper.
CR [Anonymous], JAMA
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NR 26
TC 137
Z9 141
U1 2
U2 8
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1936-878X
J9 JACC-CARDIOVASC IMAG
JI JACC-Cardiovasc. Imag.
PD JAN
PY 2011
VL 4
IS 1
BP 27
EP 33
DI 10.1016/j.jcmg.2010.09.019
PG 7
WC Cardiac & Cardiovascular Systems; Radiology, Nuclear Medicine & Medical
   Imaging
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Radiology, Nuclear Medicine &
   Medical Imaging
GA 712EX
UT WOS:000286648600004
PM 21232700
OA Bronze
DA 2025-06-11
ER

PT J
AU Nkeh-Chungag, BN
   Engwa, GA
   Businge, C
   Mdondolo, M
   Medina, MP
   Goswami, N
AF Nkeh-Chungag, Benedicta Ngwenchi
   Engwa, Godwill Azeh
   Businge, Charles
   Mdondolo, Mziwohlanga
   Medina, Magdevy Pajaro
   Goswami, Nandu
TI Assessment of the impact of HIV infection and anti-retroviral treatment
   on the cardiometabolic health of pregnant mothers and their offspring
   (ARTMOMSBABES)
SO BMC CARDIOVASCULAR DISORDERS
LA English
DT Article
DE Cardiovascular diseases; Anti-retroviral treatment; Human
   immunodeficiency virus; Epigenetics; Endothelial dysfunction
ID CARDIOVASCULAR RISK-FACTORS; ENDOTHELIAL FUNCTION; BLOOD-PRESSURE;
   DISEASE RISK; CHILDREN; THERAPY
AB BackgroundThe risk of cardiovascular diseases (CVDs) is becoming more prevalent in pregnant women though not much data is available for pregnant women with human immunodeficiency virus (HIV). Foetoplacental vascular endothelial dysfunction is thought to be at the origin of chronic diseases such as diabetes and obesity later on in life. Because HIV and anti-retroviral treatment (ARTs) are associated with endothelial dysfunction, children exposed in utero to these conditions may be at greater risk of developing CVDs. Despite the high prevalence of HIV in pregnant South African women, little is known about the effects of ART on the cardiovascular health of the mother and offspring. Hence, the proposed study intends to investigate how HIV/ARTs may affect the cardiovascular health of the mother and offspring at different time points during the pregnancy and up to 2 years after birth.MethodsA longitudinal case-control study in HIV positive pregnant women on ART and HIV negative pregnant women will be conducted. All pregnant women will be assessed for cardio-metabolic risk factors and markers (lipids, anthropometric and glycaemic indies, oxidative stress), hemodynamic status (blood pressure parameters) and vascular function (arterial compliance, retinal microvasculature, uterine artery mean pulsatility index). Child health will be monitored in utero and postnatally via routine foetal health screening, placental integrity, anthropometry, blood pressure parameters, markers of oxidative stress and endothelial function in cord blood and cardiovascular epigenetic markers in urine. DiscussionThere is a paucity of studies in South Africa and sub-Sahara Africa as a whole that utilised a longitudinal study model to assess the effects of ARTs on vascular endothelial changes in pregnant women living with HIV and the cardiometabolic health of their offspring. This study will therefore help to monitor changes in cardiometabolic risk during pregnancy and in children exposed in utero to HIV-infection and ART use. Findings from this study will provide useful information for developing guidelines on the use of ARTs in pregnancy and management of cardiometabolic health of the offspring of HIV positive mothers.
C1 [Nkeh-Chungag, Benedicta Ngwenchi; Engwa, Godwill Azeh] Walter Sisulu Univ PBX1, Fac Nat Sci, Dept Biol & Environm Sci, ZA-5117 Mthatha, South Africa.
   [Businge, Charles] Walter Sisulu Univ, Nelson Mandela Acad Hosp, Dept Obstet & Gynaecol, ZA-5117 Mthatha, South Africa.
   [Mdondolo, Mziwohlanga] Mthatha Reg Hosp, Dept Obstet & Gynaecol, Private Bag X 5014, ZA-5099 Mthatha, South Africa.
   [Medina, Magdevy Pajaro] Mthatha Reg Hosp, Dept Peadiatr, Private Bag X 5014, ZA-5099 Mthatha, South Africa.
   [Goswami, Nandu] Med Univ Graz, Otto Loewi Res Ctr Vasc Biol Immunol & Inflammat, Physiol Div, Neue Stiftingtalstr 6, A-8036 Graz, Austria.
C3 University of Kwazulu Natal; Walter Sisulu University; Medical
   University of Graz
RP Nkeh-Chungag, BN (corresponding author), Walter Sisulu Univ PBX1, Fac Nat Sci, Dept Biol & Environm Sci, ZA-5117 Mthatha, South Africa.
EM bnkehchungag@wsu.ac.za
RI Chungag, Benedicta/AAU-8632-2021; Businge, Charles/E-6248-2018; Azeh
   Engwa, Godwill/T-1577-2017
OI Nkeh-Chungag, Benedicta Ngwenchi/0000-0003-4805-4051; Azeh Engwa,
   Godwill/0000-0002-0044-9890
FU South African National Research Foundation (NRF) under Competitive
   Programme for Rated Researchers [129245]
FX This study was funded by the South African National Research Foundation
   (NRF) under Competitive Programme for Rated Researchers with Grant No.:
   129245. The funding source has no role in the collection, analysis, or
   interpretation of the data or in the decision to submit the manuscript
   for publication.
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NR 59
TC 3
Z9 3
U1 0
U2 4
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1471-2261
J9 BMC CARDIOVASC DISOR
JI BMC Cardiovasc. Disord.
PD JUN 30
PY 2021
VL 21
IS 1
AR 322
DI 10.1186/s12872-021-02130-2
PG 10
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA TG2TG
UT WOS:000671261900005
PM 34193034
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Collins, KH
   Herzog, W
   MacDonald, GZ
   Reimer, RA
   Rios, JL
   Smith, IC
   Zernicke, RF
   Hart, DA
AF Collins, Kelsey H.
   Herzog, Walter
   MacDonald, Graham Z.
   Reimer, Raylene A.
   Rios, Jaqueline L.
   Smith, Ian C.
   Zernicke, Ronald F.
   Hart, David A.
TI Obesity, Metabolic Syndrome, and Musculoskeletal Disease: Common
   Inflammatory Pathways Suggest a Central Role for Loss of Muscle
   Integrity
SO FRONTIERS IN PHYSIOLOGY
LA English
DT Review
DE joint diseases; muscle; bone; tendon; NFkB; MAPK
ID DIET-INDUCED OBESITY; GLYCATION END-PRODUCTS; HIGH-FAT DIET;
   NECROSIS-FACTOR-ALPHA; SKELETAL-MUSCLE; GUT MICROBIOTA; ADIPOSE-TISSUE;
   KNEE OSTEOARTHRITIS; SARCOPENIC OBESITY; OXIDATIVE STRESS
AB Inflammation can arise in response to a variety of stimuli, including infectious agents, tissue injury, autoimmune diseases, and obesity. Some of these responses are acute and resolve, while others become chronic and exert a sustained impact on the host, systemically, or locally. Obesity is now recognized as a chronic low-grade, systemic inflammatory state that predisposes to other chronic conditions including metabolic syndrome (MetS). Although obesity has received considerable attention regarding its pathophysiological link to chronic cardiovascular conditions and type 2 diabetes, the musculoskeletal (MSK) complications (i.e., muscle, bone, tendon, and joints) that result from obesity-associated metabolic disturbances are less frequently interrogated. As musculoskeletal diseases can lead to the worsening of MetS, this underscores the imminent need to understand the cause and effect relations between the two, and the convergence between inflammatory pathways that contribute to MSK damage. Muscle mass is a key predictor of longevity in older adults, and obesity-induced sarcopenia is a significant risk factor for adverse health outcomes. Muscle is highly plastic, undergoes regular remodeling, and is responsible for the majority of total body glucose utilization, which when impaired leads to insulin resistance. Furthermore, impaired muscle integrity, defined as persistent muscle loss, intramuscular lipid accumulation, or connective tissue deposition, is a hallmark of metabolic dysfunction. In fact, many common inflammatory pathways have been implicated in the pathogenesis of the interrelated tissues of the musculoskeletal system (e.g., tendinopathy, osteoporosis, and osteoarthritis). Despite these similarities, these diseases are rarely evaluated in a comprehensive manner. The aim of this review is to summarize the common pathways that lead to musculoskeletal damage and disease that result from and contribute to MetS. We propose the overarching hypothesis that there is a central role for muscle damage with chronic exposure to an obesity-inducing diet. The inflammatory consequence of diet and muscle dysregulation can result in dysregulated tissue repair and an imbalance toward negative adaptation, resulting in regulatory failure and other musculoskeletal tissue damage. The commonalities support the conclusion that musculoskeletal pathology with MetS should be evaluated in a comprehensive and integrated manner to understand risk for other MSK-related conditions. Implications for conservative management strategies to regulate MetS are discussed, as are future research opportunities.
C1 [Collins, Kelsey H.; Herzog, Walter; MacDonald, Graham Z.; Reimer, Raylene A.; Rios, Jaqueline L.; Smith, Ian C.; Zernicke, Ronald F.; Hart, David A.] Univ Calgary, Fac Kinesiol, Human Performance Lab, Calgary, AB, Canada.
   [Collins, Kelsey H.; Herzog, Walter; Rios, Jaqueline L.; Hart, David A.] Univ Calgary, McCaig Inst Bone & Joint Hlth, Calgary, AB, Canada.
   [Reimer, Raylene A.] Univ Calgary, Dept Biochem & Mol Biol, Calgary, AB, Canada.
   [Rios, Jaqueline L.] CAPES Fdn, Brasilia, DF, Brazil.
   [Zernicke, Ronald F.] Univ Michigan, Sch Kinesiol, Dept Orthopaed Surg, Ann Arbor, MI 48109 USA.
   [Zernicke, Ronald F.] Univ Michigan, Sch Kinesiol, Dept Biomed Engn, Ann Arbor, MI 48109 USA.
   [Zernicke, Ronald F.] Univ Calgary, Dept Physiol & Pharmacol, Dept Surg, Calgary, AB, Canada.
   [Hart, David A.] Univ British Columbia, Dept Family Practice, Ctr Hip Hlth & Mobil, Vancouver, BC, Canada.
   [Hart, David A.] Alberta Hlth Serv Bone & Joint Hlth Strateg Clin, Calgary, AB, Canada.
C3 University of Calgary; University of Calgary; University of Calgary;
   Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES);
   University of Michigan System; University of Michigan; University of
   Michigan System; University of Michigan; University of Calgary;
   University of British Columbia; Alberta Health Services (AHS)
RP Hart, DA (corresponding author), Univ Calgary, Fac Kinesiol, Human Performance Lab, Calgary, AB, Canada.; Hart, DA (corresponding author), Univ Calgary, McCaig Inst Bone & Joint Hlth, Calgary, AB, Canada.; Hart, DA (corresponding author), Univ British Columbia, Dept Family Practice, Ctr Hip Hlth & Mobil, Vancouver, BC, Canada.; Hart, DA (corresponding author), Alberta Hlth Serv Bone & Joint Hlth Strateg Clin, Calgary, AB, Canada.
EM hartd@ucalgary.ca
RI Smith, Ian/HHD-2243-2022; Herzog, Walter/AAG-7188-2020; Rios, Jaqueline
   Lourdes/V-9976-2018
OI Herzog, Walter/0000-0002-5341-0033; Reimer, Raylene/0000-0001-5088-7947;
   Rios, Jaqueline Lourdes/0000-0002-3679-2869; Smith, Ian
   C./0000-0001-5269-1710
FU Canadian Institutes of Health Research [RT736475, MOP 115076]; Canada
   Research Chair Programme; Alberta Innovates Health Solutions
   Osteoarthritis Team Grant; Alberta Innovates Health Solutions; Alberta
   Health Services Strategic Clinical Network Program; Canadian Institutes
   of Health Research Banting and Best Canada Graduate Scholarship; Killam
   Foundation
FX This work was supported by the Canadian Institutes of Health Research #
   RT736475 and MOP 115076, the Canada Research Chair Programme, the
   Alberta Innovates Health Solutions Osteoarthritis Team Grant, Alberta
   Innovates Health Solutions, Alberta Health Services Strategic Clinical
   Network Program, Canadian Institutes of Health Research Banting and Best
   Canada Graduate Scholarship, and the Killam Foundation. Due to space and
   scope limitations, we apologize to authors in this area whose work we
   were unable to include in the present review.
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NR 230
TC 193
Z9 208
U1 3
U2 11
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1664-042X
J9 FRONT PHYSIOL
JI Front. Physiol.
PD FEB 23
PY 2018
VL 9
AR 112
DI 10.3389/fphys.2018.00112
PG 25
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA FX3TB
UT WOS:000425994100001
PM 29527173
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Mansur, RB
   Brietzke, E
   McIntyre, RS
AF Mansur, Rodrigo B.
   Brietzke, Elisa
   McIntyre, Roger S.
TI Is there a "metabolic-mood syndrome"? A review of the relationship
   between obesity and mood disorders
SO NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
LA English
DT Review
DE Mood disorders; Major depressive disorder; Bipolar disorder; Subtypes;
   Obesity; Metabolic syndrome; Diabetes mellitus; Metabolism; RDoC;
   Research domain criteria
ID BODY-MASS INDEX; MAJOR DEPRESSIVE DISORDER; PITUITARY-ADRENAL AXIS;
   MAGNETIC-RESONANCE-SPECTROSCOPY; RANDOMIZED CONTROLLED-TRIAL;
   HIPPOCAMPAL SYNAPTIC PLASTICITY; TREATMENT ENHANCEMENT PROGRAM; BRAIN
   MITOCHONDRIAL-FUNCTION; EUTHYMIC BIPOLAR DISORDER; INTENTIONAL
   WEIGHT-LOSS
AB Obesity and mood disorders are highly prevalent and co-morbid. Epidemiological studies have highlighted the public health relevance of this association, insofar as both conditions and its co-occurrence are associated with a staggering illness-associated burden. Accumulating evidence indicates that obesity and mood disorders are intrinsically linked and share a series of clinical, neurobiological, genetic and environmental factors. The relationship of these conditions has been described as convergent and bidirectional; and some authors have attempted to describe a specific subtype of mood disorders characterized by a higher incidence of obesity and metabolic problems. However, the nature of this association remains poorly understood. There are significant inconsistencies in the studies evaluating metabolic and mood disorders; and, as a result, several questions persist about the validity and the generalizability of the findings. An important limitation in this area of research is the noteworthy phenotypic and pathophysiological heterogeneity of metabolic and mood disorders. Although clinically useful, categorical classifications in both conditions have limited heuristic value and its use hinders a more comprehensive understanding of the association between metabolic and mood disorders. A recent trend in psychiatry is to move toward a domain specific approach, wherein psychopathology constructs are agnostic to DSM-defined diagnostic categories and, instead, there is an effort to categorize domains based on pathogenic substrates, as proposed by the National Institute of Mental Health (NIMH) Research Domain Criteria Project (RDoC). Moreover, the substrates subserving psychopathology seems to be unspecific and extend into other medical illnesses that share in common brain consequences, which includes metabolic disorders. Overall, accumulating evidence indicates that there is a consistent association of multiple abnormalities in neuropsychological constructs, as well as correspondent brain abnormalities, with broad-based metabolic dysfunction, suggesting, therefore, that the existence of a "metabolic-mood syndrome" is possible. Nonetheless, empirical evidence is necessary to support and develop this concept. Future research should focus on dimensional constructs and employ integrative, multidisciplinary and multimodal approaches. (C) 2015 Elsevier Ltd. All rights reserved.
C1 [Mansur, Rodrigo B.; McIntyre, Roger S.] Univ Toronto, Univ Hlth Network, MDPU, Toronto, ON, Canada.
   [Mansur, Rodrigo B.; Brietzke, Elisa] Univ Fed Sao Paulo, Dept Psychiat, LINC, Sao Paulo, Brazil.
C3 University of Toronto; University Health Network Toronto; Universidade
   Federal de Sao Paulo (UNIFESP)
RP Mansur, RB (corresponding author), 399 Bathurst St,MP 9-325, Toronto, ON M5T 2S8, Canada.
EM rodrigomansur71@uol.com.br
RI McIntyre, Roger/AAU-1000-2020; Mansur, Rodrigo/N-7131-2019; Brietzke,
   Elisa/G-9559-2012
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TC 232
Z9 249
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PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0149-7634
EI 1873-7528
J9 NEUROSCI BIOBEHAV R
JI Neurosci. Biobehav. Rev.
PD MAY
PY 2015
VL 52
BP 89
EP 104
DI 10.1016/j.neubiorev.2014.12.017
PG 16
WC Behavioral Sciences; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Behavioral Sciences; Neurosciences & Neurology
GA CG8YJ
UT WOS:000353601300007
PM 25579847
DA 2025-06-11
ER

PT J
AU Corona, G
   Fagioli, G
   Mannucci, E
   Romeo, A
   Rossi, M
   Lotti, F
   Sforza, A
   Morittu, S
   Chiarini, V
   Casella, G
   Di Pasquale, G
   Bandini, E
   Forti, G
   Maggi, M
AF Corona, Giovanni
   Fagioli, Giorgio
   Mannucci, Edoardo
   Romeo, Annadina
   Rossi, Massimiliano
   Lotti, Francesco
   Sforza, Alessandra
   Morittu, Stefano
   Chiarini, Valerio
   Casella, Gianni
   Di Pasquale, Giuseppe
   Bandini, Elisa
   Forti, Gianni
   Maggi, Mario
TI Penile Doppler Ultrasound in Patients with Erectile Dysfunction (ED):
   Role of Peak Systolic Velocity Measured in the Flaccid State in
   Predicting Arteriogenic ED and Silent Coronary Artery Disease
SO JOURNAL OF SEXUAL MEDICINE
LA English
DT Article
DE Cardiovascular Disease; Cardiovascular Risk; Erectile Dysfunction;
   Penile Doppler Ultrasound; SIEDY
ID MYOCARDIAL-ISCHEMIA; METABOLIC SYNDROME; DUPLEX ULTRASOUND;
   TESTOSTERONE; MEN; ADENOSINE; ASSOCIATION; RELAXATION; PREVALENCE;
   MECHANISMS
AB The use of the penile peak systolic velocity (PSV) measured in the flaccid state during penile color Doppler ultrasound (PCDU) examination has been questioned without substantial evidence.
   To assess the validity of PSV measured in the flaccid state during PCDU, in patients consulting for erectile dysfunction (ED).
   A consecutive series of 1,346 (mean age 55.0 +/- 12.0 years) male patients was studied.
   All patients underwent PCDU performed both in the flaccid state and dynamic (after prostaglandin E1 stimulation) conditions. A subset of 20 subjects with uncomplicated type 2 diabetes underwent diagnostic testing for silent coronary heart disease by means of adenosine stress myocardial perfusion scintigraphy (SPECT). In these subjects penile arterial flow was simultaneously assessed by PCDU before and after systemic adenosine administration.
   Flaccid PSV showed a significant (r = 0.513, P < 0.0001) correlation with dynamic PSV. Receiver operating characteristic (ROC) curve analysis demonstrated that when a threshold of 13 cm/seconds was chosen, flaccid PSV was predictive for dynamic PSV < 25 and < 35 cm/seconds with an accuracy of 89% and 82%, respectively. Among the subset of patients who underwent SPECT, an impaired coronary flow reserve (ICFR) occurred in nine cases (45%). When the same threshold of < 13 cm/seconds was chosen, PSV before SPECT was predictive of ICFR with an accuracy of 80% (area under the ROC curve = 0.798 +/- 0.10; P < 0.05). After adjustment for confounders, anxiety symptoms were related to dynamic PSV (Adj. r = -0.154, P < 0.05) but not to flaccid PSV.
   Our results show that flow in the cavernosal arteries can be routinely evaluated by PCDU in the flaccid state. Performing PCDU only in the flaccid state allows identifying subjects with pathological dynamic PSV with accuracy higher than 80%. Furthermore, our preliminary data suggest that the same examination could identify diabetic subjects with ICFR with an accuracy of 80%. Corona G, Fagioli G, Mannucci E, Romeo A, Rossi M, Lotti F, Sforza A, Morittu S, Chiarini V, Casella G, Di Pasquale G, Bandini E, Forti G, and Maggi M. Penile Doppler ultrasound in patients with erectile dysfunction (ED): Role of peak systolic velocity measured in the flaccid state in predicting arteriogenic ED and silent coronary artery disease. J Sex Med 2008;5:2623-2634.
C1 [Corona, Giovanni; Lotti, Francesco; Bandini, Elisa; Forti, Gianni; Maggi, Mario] Univ Florence, Androl Unit, Dept Clin Physiopathol, I-50139 Florence, Italy.
   [Corona, Giovanni; Sforza, Alessandra; Morittu, Stefano; Chiarini, Valerio] Maggiore Bellaria Hosp, Endocrinol Unit, Bologna, Italy.
   [Fagioli, Giorgio; Romeo, Annadina; Rossi, Massimiliano] Nucl Med Maggiore Bellaria Hosp, Bologna, Italy.
   [Mannucci, Edoardo] Univ Florence, Dept Crit Care, Diabet Sect, Geriatr Unit, I-50139 Florence, Italy.
   [Casella, Gianni; Di Pasquale, Giuseppe] Maggiore Bellaria Hosp, Cardiol Unit, Bologna, Italy.
C3 University of Florence; AUSL di Bologna; AUSL di Bologna; University of
   Florence; AUSL di Bologna
RP Maggi, M (corresponding author), Univ Florence, Androl Unit, Dept Clin Physiopathol, Viale Pieraccini 6, I-50139 Florence, Italy.
EM m.maggi@dfc.unifi.it
RI Casella, Gianni/AAD-8105-2021; Maggi, Mario/AAB-8284-2019; Lotti,
   Francesco/AAC-3186-2019; LOTTI, Francesco/K-1801-2018; Mannucci,
   Edoardo/K-6749-2016
OI MAGGI, Mario/0000-0003-3267-4221; LOTTI, Francesco/0000-0001-8343-1807;
   CASELLA, Gianni/0000-0002-0701-7329; Mannucci,
   Edoardo/0000-0001-9759-9408
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NR 47
TC 117
Z9 119
U1 0
U2 6
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1743-6095
EI 1743-6109
J9 J SEX MED
JI J. Sex. Med.
PD NOV
PY 2008
VL 5
IS 11
BP 2623
EP 2634
DI 10.1111/j.1743-6109.2008.00982.x
PG 12
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 374UB
UT WOS:000261068100016
PM 18783349
DA 2025-06-11
ER

PT J
AU Azad, BJ
   Yaseri, M
   Daneshzad, E
   Koohdani, F
AF Azad, Banafsheh Jafari
   Yaseri, Mehdi
   Daneshzad, Elnaz
   Koohdani, Fariba
TI Interaction between Apo A-II-265T > C polymorphism and dietary total
   antioxidant capacity on some oxidative stress and inflammatory markers
   in patients with type 2 diabetes mellitus
SO BRITISH JOURNAL OF NUTRITION
LA English
DT Article
DE Apo A2; Dietary total antioxidant capacity; Interaction; Polymorphism
ID APOLIPOPROTEIN-A-II; FOOD-FREQUENCY QUESTIONNAIRE;
   CORONARY-ARTERY-DISEASE; FATTY-ACIDS INTAKE; BODY-MASS INDEX;
   MEDITERRANEAN DIET; REACTIVE PROTEIN; HEALTHY-ADULTS; ASSOCIATION; GENE
AB This work aims to examine the interaction between apo A2 (Apo A-II) -265T > C SNP and dietary total antioxidant capacity (DTAC) on inflammation and oxidative stress in patients with type 2 diabetes mellitus. The present cross-sectional study included 180 patients (35-65 years) with identified Apo A-II genotype. Dietary intakes were assessed by a FFQ. DTAC was computed using the international databases. IL-18 (IL18), high-sensitivity C-reactive protein (hs-CRP), pentraxin (PTX3), serum total antioxidant capacity (TAC), superoxide dismutase (SOD) activity and 8-isoprostaneF2 alpha (PGF2 alpha) markers were obtained according to standard protocols. General linear model was used to evaluate the interaction. The interaction of gene and DTAC (P (FRAP) = 0 center dot 039 and P (ORAC) = 0 center dot 042) on PGF2 alpha level was significant after adjusting for confounders. A significant interaction was observed on IL18 level (P (ORAC) = 0 center dot 018 and P (FRAP) = 0 center dot 048) and SOD (P (TEAC) = 0 center dot 037) in obese patients. Among patients whose DTAC was higher than the median intake, the levels of hs-CRP and PGF2 alpha were significantly higher only in individuals with CC genotype. Serum TAC (P (FRAP) = 0 center dot 030, P (ORAC) = 0 center dot 049) and SOD were significantly lower in the CC genotype. There was a favourable relationship between the high-DTAC and SOD (obese: P (TEAC) = 0 center dot 034, non-obese: P (FRAP) = 0 center dot 001, P (TRAP) < 0 center dot 0001, P (TEAC) = 0 center dot 003 and P (ORAC) = 0 center dot 001) and PGF2 alpha (non-obese: P (ORAC) = 0 center dot 024) in T-allele carriers. The rs5082 SNP interacts with DTAC to influence several cardiometabolic risk factors. Also, we found dietary recommendations for antioxidant-rich foods intake might be useful in the prevention of diabetes complications in the T carrier more effectively than the CC genotype. Future large studies are required to confirm these results.
C1 [Azad, Banafsheh Jafari; Koohdani, Fariba] Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Cellular & Mol Nutr, Tehran, Iran.
   [Yaseri, Mehdi] Univ Tehran Med Sci, Sch Publ Hlth, Dept Epidemiol & Biostat, Tehran, Iran.
   [Daneshzad, Elnaz] Alborz Univ Med Sci, Noncommunicable Dis Res Ctr, Karaj, Iran.
   [Koohdani, Fariba] Univ Tehran Med Sci, Diabet Res Ctr, Endocrinol & Metab Clin Sci Inst, Tehran, Iran.
C3 Tehran University of Medical Sciences; Tehran University of Medical
   Sciences; Alborz University of Medical Sciences; Tehran University of
   Medical Sciences
RP Koohdani, F (corresponding author), Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Cellular & Mol Nutr, Tehran, Iran.; Koohdani, F (corresponding author), Univ Tehran Med Sci, Diabet Res Ctr, Endocrinol & Metab Clin Sci Inst, Tehran, Iran.
EM fkoohdan@sina.tums.ac.ir
RI Koohdani, Fariba/D-1298-2018; Daneshzad, Elnaz/O-3694-2018; Yaseri,
   Mehdi/I-1645-2018
OI Daneshzad, Elnaz/0000-0003-1400-8532; Yaseri, Mehdi/0000-0002-4066-873X
FU Tehran University of Medical Sciences Health Services [97-03-161-41169];
   ethics committee at Tehran University of Medical Sciences [IR.TUMS.VCR.
   REC.1398.298]
FX This research has been supported by Tehran University of Medical
   Sciences &Health Services (grant number: (97-03-161-41169)). Also, this
   study was approved by the ethics committee at Tehran University of
   Medical Sciences (IR.TUMS.VCR. REC.1398.298).
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NR 75
TC 4
Z9 4
U1 0
U2 1
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1145
EI 1475-2662
J9 BRIT J NUTR
JI Br. J. Nutr.
PD JUL 14
PY 2022
VL 128
IS 1
BP 13
EP 29
AR PII S0007114521002993
DI 10.1017/S0007114521002993
EA AUG 2021
PG 17
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 2U4WX
UT WOS:000744713500001
PM 34372957
DA 2025-06-11
ER

PT J
AU Kurian, J
   Nanjundaih, RM
   Deo, G
AF Kurian, Jintu
   Nanjundaih, Ramesh Mavathur
   Deo, Guru
TI Mechanism of physical activity in the prevention and management of type
   2 diabetes mellitus: A short review
SO JOURNAL OF DIABETOLOGY
LA English
DT Review
DE COVID-19 pandemic; diabetes mellitus; glucose homeostasis; glycemic
   variability; physical activity; pre-diabetes; prevalence
ID INSULIN-RESISTANCE; OXIDATIVE STRESS; GLYCEMIC CONTROL; FATTY-ACIDS;
   BETA-CELLS; EXERCISE; ASSOCIATION; INTENSITY; RISK; FITNESS
AB Background: Pre-diabetes (PDM) is a state with impaired glucose tolerance and/or impaired fasting glucose where people are at risk for diabetes. In less than 3 years, PDM gets converted to diabetes. Physical activity (PA) is a boon to PDM and diabetes to gain control over the glycemic variability and insulin secretion, reduction in cardiometabolic risk, and improvement in overall health. Increasing PA helps delay or prevent the conversion of PDM to diabetes mellitus (DM), as well as helps prevent complications of diabetes effectively. Materials and Methods: The aim of the review was to understand the mechanism by which PA can help to prevent and manage DM. Research papers, manuscripts, and review papers on PA and its mechanism of action on prevention and management of diabetes were searched and relevant contents were studied. One hundred and twelve papers were chosen from online sources like Google Scholar, Scopus, PubMed, Sci-Hub, and Library Genesis. Fifty-seven articles were shortlisted and out of them 54 included in this mini-review comprising of meta-analysis, systematic review, and randomized control trials. Fifty-seven articles were excluded due to irrelevant content in the contexts of diabetes and its mechanism. Result: The review resulted in getting a better understanding of the possible mechanisms by which PA works in prevention and management of DM and delaying the onset of diabetes in PDM. In addition to that, the highest known risk factors for diabetes in this current scenario are understood as physical inactivity among youngsters, along with low nutrition high-quality diet, stress, low-quality sleep, and associated fat and glucose metabolism. Conclusion: During pandemics like coronavirus disease 2019 (COVID-19), physically being active also has its role in reducing resistance power and metabolism of fat and glucose, thereby increasing the risk for diabetes. It is always better to keep oneself with some exercise daily to maintain surface immunity high and strong to avoid diseases. This is possible by modification of lifestyle with yoga, exercises, and proper diet. Periodic incorporation of indoor-outdoor activities aiming at cutting short period of inactivity will help prevent and manage diabetes and other metabolic endocrine disorders to a large extent.
C1 [Kurian, Jintu] Swami Vivekananda Yoga Anusandhana Samsthana, Dept Life Sci, Bengaluru, Karnataka, India.
   [Nanjundaih, Ramesh Mavathur] Swami Vivekananda Yoga Anusandhana Samsthana, Mol Biosci Res Lab, Bengaluru, Karnataka, India.
   [Deo, Guru] Morarji Desai Natl Inst Yoga, Dept Yoga Therapy, 68 Ashoka Rd, New Delhi 110001, India.
RP Deo, G (corresponding author), Morarji Desai Natl Inst Yoga, Dept Yoga Therapy, 68 Ashoka Rd, New Delhi 110001, India.
EM gurudeo.yoga@gmail.com
RI mavathur nanjundaiah, ramesh/GQI-1471-2022
OI mavathur nanjundaiah, ramesh/0000-0003-3017-9913
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NR 54
TC 1
Z9 1
U1 0
U2 3
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, Maharashtra, INDIA
SN 2543-3288
EI 2078-7685
J9 J DIABETOL
JI J. Diabetol.
PD JUL-SEP
PY 2021
VL 12
IS 3
BP 257
EP 262
DI 10.4103/JOD.JOD_68_20
PG 6
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA YY2GF
UT WOS:000754610500004
OA gold
DA 2025-06-11
ER

PT J
AU Lundqvist, S
   Börjesson, M
   Cider, Å
   Hagberg, L
   Ottehall, CB
   Sjöström, J
   Larsson, MEH
AF Lundqvist, Stefan
   Borjesson, Mats
   Cider, Asa
   Hagberg, Lars
   Ottehall, Camilla Bylin
   Sjostrom, Johan
   Larsson, Maria E. H.
TI Long-term physical activity on prescription intervention for patients
   with insufficient physical activity level-a randomized controlled trial
SO TRIALS
LA English
DT Article
DE Primary health care; Physical activity; Metabolic syndrome; Quality of
   life; Health behaviour; Physical therapy
ID PRIMARY-HEALTH-CARE; ACTIVITY QUESTIONNAIRE; SPORTS-MEDICINE;
   BEHAVIOR-CHANGE; SHORT-FORM; FOLLOW-UP; DISEASE; ADULTS;
   RECOMMENDATIONS; POPULATION
AB BackgroundPhysical activity (PA) can be used to prevent and treat diseases. In Sweden, licensed healthcare professionals use PA on prescription (PAP) to support patients to increase their PA level. The aim of this randomized controlled trial was to evaluate a 2-year intervention of two different strategies of PAP treatment for patients with insufficient PA level, after a previous 6-month period of ordinary PAP treatment in a primary health care setting.MethodsWe included 190 patients, 27-77years, physically inactive with metabolic risk factors where the patients were not responding to a previous 6-month PAP treatment with increased PA. The patients were randomized to either enhanced support from a physiotherapist (PT group) or continued ordinary PAP treatment at the health care centre (HCC group). The PAP treatment included an individualized dialogue; an individually dosed PA recommendation, including a written prescription; and a structured follow-up. In addition to PAP, the PT group received aerobic fitness tests and more frequent scheduled follow-ups. The patient PA level, metabolic health, and health-related quality of life (HRQOL) were measured at baseline and at 1- and 2-year follow-ups.ResultsAt the 2-year follow-up, 62.9% of the PT group and 50.8% of the HCC group had increased their PA level and 31.4% vs. 38.5% achieved >= 150min of moderate-intensity PA/week (difference between groups n.s.). Over 2 years, both groups displayed increased high-density lipoproteins (HDL) (p=0.004 vs. baseline), increased mental health status (MCS) (p=0.036), and reduced body mass index (BMI) (p=0.001), with no difference between groups.ConclusionDuring long-term PAP interventions, the PA level, metabolic health, and HRQOL increased in patients at metabolic risk without significant differences between groups. The results indicate to be independent of any changes in pharmacological treatment. We demonstrated that the PAP treatment was feasible in ordinary primary care. Both the patients and the healthcare system benefitted from the improvement in metabolic risk factors. Future studies should elucidate effective long-term PAP-treatment strategies.Trial registrationClinicalTrials.gov NCT03012516. Registered on 30 December 2016-retrospectively registered.
C1 [Lundqvist, Stefan; Cider, Asa; Larsson, Maria E. H.] Univ Gothenburg, Inst Neurosci & Physiol, Sahlgrenska Acad, Unit Physiotherapy,Dept Hlth & Rehabil, Gothenburg, Sweden.
   [Lundqvist, Stefan; Ottehall, Camilla Bylin; Sjostrom, Johan] Ctr Fysisk Aktivitet Goteborg, Gothenburg, Region Vastra G, Sweden.
   [Borjesson, Mats] Univ Gothenburg, Ctr Hlth & Performance CHP, Gothenburg, Sweden.
   [Borjesson, Mats] Univ Gothenburg, Sahlgrenska Acad, Inst Med, Gothenburg, Sweden.
   [Borjesson, Mats] Sahlgrens Univ Hosp, Gothenburg, Region Vastra G, Sweden.
   [Hagberg, Lars] Orebro Univ, Fac Med & Hlth, Univ Hlth Care Res Ctr, Orebro, Sweden.
   [Larsson, Maria E. H.] Res & Dev Primary Hlth Care, Gothenburg, Region Vastra G, Sweden.
C3 University of Gothenburg; University of Gothenburg; University of
   Gothenburg; University of Gothenburg; Sahlgrenska University Hospital;
   Orebro University
RP Lundqvist, S (corresponding author), Univ Gothenburg, Inst Neurosci & Physiol, Sahlgrenska Acad, Unit Physiotherapy,Dept Hlth & Rehabil, Gothenburg, Sweden.; Lundqvist, S (corresponding author), Ctr Fysisk Aktivitet Goteborg, Gothenburg, Region Vastra G, Sweden.
EM stefan.lundqvist@vgregion.se
RI Lundqvist, Stefan/LWI-5029-2024; Larsson, Maria/IZE-0424-2023
FU Research and Development Primary Health Care, Region Vastra Gotaland,
   Gothenburg, Sweden; University of Gothenburg
FX Funding was provided as economic support for doctoral thesis by Research
   and Development Primary Health Care, Region Vastra Gotaland, Gothenburg,
   Sweden. The funder had no role in study design, data collection and
   analysis, decision to publish, or preparation of the manuscript.
   https://www.vgregion.se/f/regionhalsan/FoU-primarvard/fou-centrum2/fou-c
   entrumgoteborg-och-sodra-bohuslan/.Open access funding provided by
   University of Gothenburg.
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NR 46
TC 13
Z9 15
U1 0
U2 4
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1745-6215
J9 TRIALS
JI Trials
PD SEP 15
PY 2020
VL 21
IS 1
AR 793
DI 10.1186/s13063-020-04727-y
PG 11
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Research & Experimental Medicine
GA NT9TJ
UT WOS:000573284300004
PM 32933577
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Martin, SS
   Aday, AW
   Almarzooq, ZI
   Anderson, CAM
   Arora, P
   Avery, CL
   Baker-Smith, CM
   Gibbs, BB
   Beaton, AZ
   Boehme, AK
   Commodore-Mensah, Y
   Currie, ME
   Elkind, MSV
   Evenson, KR
   Generoso, G
   Heard, DG
   Hiremath, S
   Johansen, MC
   Kalani, R
   Kazi, DS
   Ko, D
   Liu, JX
   Magnani, JW
   Michos, ED
   Mussolino, ME
   Navaneethan, SD
   Parikh, NI
   Perman, SM
   Poudel, R
   Rezk-Hanna, M
   Roth, GA
   Shah, NS
   St-Onge, MP
   Thacker, EL
   Tsao, CW
   Urbut, SM
   Van Spall, HGC
   Voeks, JH
   Wang, NY
   Wong, ND
   Wong, SS
   Yaffe, K
   Palaniappan, LP
AF Martin, Seth S.
   Aday, Aaron W.
   Almarzooq, Zaid I.
   Anderson, Cheryl A. M.
   Arora, Pankaj
   Avery, Christy L.
   Baker-Smith, Carissa M.
   Gibbs, Bethany Barone
   Beaton, Andrea Z.
   Boehme, Amelia K.
   Commodore-Mensah, Yvonne
   Currie, Maria E.
   Elkind, Mitchell S. V.
   Evenson, Kelly R.
   Generoso, Giuliano
   Heard, Debra G.
   Hiremath, Swapnil
   Johansen, Michelle C.
   Kalani, Rizwan
   Kazi, Dhruv S.
   Ko, Darae
   Liu, Junxiu
   Magnani, Jared W.
   Michos, Erin D.
   Mussolino, Michael E.
   Navaneethan, Sankar D.
   Parikh, Nisha I.
   Perman, Sarah M.
   Poudel, Remy
   Rezk-Hanna, Mary
   Roth, Gregory A.
   Shah, Nilay S.
   St-Onge, Marie-Pierre
   Thacker, Evan L.
   Tsao, Connie W.
   Urbut, Sarah M.
   Van Spall, Harriette G. C.
   Voeks, Jenifer H.
   Wang, Nae-Yuh
   Wong, Nathan D.
   Wong, Sally S.
   Yaffe, Kristine
   Palaniappan, Latha P.
CA Amer Heart Assoc Council Epidemiol Prevent Stat Comm Stroke Stat Subcomm
TI 2024 Heart Disease and Stroke Statistics: A Report of US and Global Data
   From the American Heart Association
SO CIRCULATION
LA English
DT Article
DE AHA Scientific Statements; cardiovascular diseases; epidemiology; risk
   factors; statistics; stroke
ID GENOME-WIDE ASSOCIATION; HOSPITAL CARDIAC-ARREST; IDEAL CARDIOVASCULAR
   HEALTH; PERIPHERAL ARTERY-DISEASE; BODY-MASS INDEX; ABDOMINAL
   AORTIC-ANEURYSM; ALL-CAUSE MORTALITY; ONSET ATRIAL-FIBRILLATION; CHRONIC
   KIDNEY-DISEASE; HIGH-SCHOOL-STUDENTS
AB BACKGROUND: The American Heart Association (AHA), in conjunction with the National Institutes of Health, annually reports the most up-to-date statistics related to heart disease, stroke, and cardiovascular risk factors, including core health behaviors (smoking, physical activity, nutrition, sleep, and obesity) and health factors (cholesterol, blood pressure, glucose control, and metabolic syndrome) that contribute to cardiovascular health. The AHA Heart Disease and Stroke Statistical Update presents the latest data on a range of major clinical heart and circulatory disease conditions (including stroke, brain health, complications of pregnancy, kidney disease, congenital heart disease, rhythm disorders, sudden cardiac arrest, subclinical atherosclerosis, coronary heart disease, cardiomyopathy, heart failure, valvular disease, venous thromboembolism, and peripheral artery disease) and the associated outcomes (including quality of care, procedures, and economic costs).
   METHODS: The AHA, through its Epidemiology and Prevention Statistics Committee, continuously monitors and evaluates sources of data on heart disease and stroke in the United States and globally to provide the most current information available in the annual Statistical Update with review of published literature through the year before writing. The 2024 AHA Statistical Update is the product of a full year's worth of effort in 2023 by dedicated volunteer clinicians and scientists, committed government professionals, and AHA staff members. The AHA strives to further understand and help heal health problems inflicted by structural racism, a public health crisis that can significantly damage physical and mental health and perpetuate disparities in access to health care, education, income, housing, and several other factors vital to healthy lives. This year's edition includes additional global data, as well as data on the monitoring and benefits of cardiovascular health in the population, with an enhanced focus on health equity across several key domains.
   RESULTS: Each of the chapters in the Statistical Update focuses on a different topic related to heart disease and stroke statistics.
   CONCLUSIONS: The Statistical Update represents a critical resource for the lay public, policymakers, media professionals, clinicians, health care administrators, researchers, health advocates, and others seeking the best available data on these factors and conditions.
C1 [Martin, Seth S.; Commodore-Mensah, Yvonne; Johansen, Michelle C.; Michos, Erin D.] Johns Hopkins Univ, Baltimore, MD 21218 USA.
   [Palaniappan, Latha P.] Stanford Univ, Stanford, CA USA.
   [Aday, Aaron W.] Vanderbilt Univ, Med Ctr, Nashville, TN USA.
   [Almarzooq, Zaid I.] Brigham & Womens Hosp, Boston, MA USA.
   [Anderson, Cheryl A. M.] Univ Calif San Diego, Family & Prevent Med, San Diego, CA USA.
   [Arora, Pankaj] Univ Alabama Birmingham, Birmingham, AL USA.
   [Avery, Christy L.; Evenson, Kelly R.] Univ North Carolina, Chapel Hill, NC USA.
   [Baker-Smith, Carissa M.] Nemours Childrens Hlth, Jacksonville, FL USA.
   [Gibbs, Bethany Barone] West Virginia Univ, Epidemiol & Biostat, Morgantown, WV USA.
   [Beaton, Andrea Z.] Cincinnati Childrens Hosp Med Ctr, Heart Inst, Cincinnati, OH USA.
   [Boehme, Amelia K.; Elkind, Mitchell S. V.] Columbia Univ, New York, NY USA.
   [Currie, Maria E.] Stanford Univ, Sch Med, Stanford, CA USA.
   [Generoso, Giuliano] Univ Sao Paulo, Ctr Clin & Epidemiol Res, Univ Hosp, Sao Paulo, SP, Brazil.
   [Heard, Debra G.; Poudel, Remy; Wong, Sally S.] Amer Heart Assoc, Dallas, TX USA.
   [Hiremath, Swapnil] Univ Ottawa, Ottawa, ON, Canada.
   [Kalani, Rizwan; Roth, Gregory A.] Univ Washington, Seattle, WA USA.
   [Kazi, Dhruv S.] Harvard Med Sch, Beth Israel Deaconess Med Ctr, Boston, MA USA.
   [Ko, Darae] Boston Univ, Boston, MA USA.
   [Liu, Junxiu] Icahn Sch Med Mt Sinai, New York, NY USA.
   [Magnani, Jared W.] Univ Pittsburgh, Pittsburgh, PA 15260 USA.
   [Mussolino, Michael E.] NHLBI, NIH, Bethesda, MD USA.
   [Navaneethan, Sankar D.] Baylor Coll Med, Jewish Inst Res, Houston, TX USA.
   [Parikh, Nisha I.; Yaffe, Kristine] Univ Calif San Francisco, San Francisco, CA USA.
   [Perman, Sarah M.] Univ Colorado, Boulder, CO USA.
   [Rezk-Hanna, Mary] Univ Calif Los Angeles, Los Angeles, CA USA.
   [Shah, Nilay S.] Northwestern Univ, Evanston, IL 60208 USA.
   [St-Onge, Marie-Pierre] Columbia Univ, Irving Med Ctr, New York, NY USA.
   [Thacker, Evan L.] Brigham Young Univ, Provo, UT USA.
   [Tsao, Connie W.] Beth Israel Deaconess Med Ctr, Boston, MA USA.
   [Perman, Sarah M.] Massachusetts Gen Hosp, Boston, MA USA.
   [Van Spall, Harriette G. C.] McMaster Univ, Hamilton, ON, Canada.
   [Voeks, Jenifer H.] Med Univ South Carolina, Charleston, SC USA.
   [Wang, Nae-Yuh] Johns Hopkins Med Inst, Baltimore, MD USA.
   [Wong, Nathan D.] Univ Calif Irvine, Heart Dis Prevent Program, Irvine, CA USA.
C3 Johns Hopkins University; Stanford University; Vanderbilt University;
   Harvard University; Harvard University Medical Affiliates; Brigham &
   Women's Hospital; University of California System; University of
   California San Diego; University of Alabama System; University of
   Alabama Birmingham; University of North Carolina; University of North
   Carolina Chapel Hill; West Virginia University; Cincinnati Children's
   Hospital Medical Center; Columbia University; Stanford University;
   Universidade de Sao Paulo; University of Ottawa; University of
   Washington; University of Washington Seattle; Harvard University;
   Harvard University Medical Affiliates; Beth Israel Deaconess Medical
   Center; Harvard Medical School; Boston University; Icahn School of
   Medicine at Mount Sinai; Pennsylvania Commonwealth System of Higher
   Education (PCSHE); University of Pittsburgh; National Institutes of
   Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI);
   Baylor College of Medicine; University of California System; University
   of California San Francisco; University of Colorado System; University
   of Colorado Boulder; University of California System; University of
   California Los Angeles; Northwestern University; NewYork-Presbyterian
   Hospital; Columbia University; Brigham Young University; Harvard
   University; Harvard University Medical Affiliates; Beth Israel Deaconess
   Medical Center; Harvard University; Harvard University Medical
   Affiliates; Massachusetts General Hospital; McMaster University; Medical
   University of South Carolina; Johns Hopkins University; Johns Hopkins
   Medicine; University of California System; University of California
   Irvine
RP Martin, SS (corresponding author), Johns Hopkins Univ, Baltimore, MD 21218 USA.
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   Aaron/MEQ-1518-2025; Almarzooq, Zaid/AAD-9893-2020; Rezk-Hanna,
   Mary/LIC-4706-2024; Commodore-Mensah, Yvonne/AAP-3381-2020; Baker-Smith,
   Carissa/ABL-0815-2022; St-Onge, Marie-Pierre/AAB-3523-2020; Roshandel,
   Gholamreza/AAJ-9562-2021; Evenson, Kelly/ABU-8365-2022
OI Shah, Nilay/0000-0003-3519-8662; Palaniappan, Latha/0000-0002-1245-665X
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NR 3794
TC 918
Z9 943
U1 188
U2 310
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0009-7322
EI 1524-4539
J9 CIRCULATION
JI Circulation
PD FEB 20
PY 2024
VL 149
IS 8
BP E347
EP E913
DI 10.1161/CIR.0000000000001209
PG 567
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA C6Y1E
UT WOS:001290797400001
PM 38264914
OA hybrid
HC Y
HP Y
DA 2025-06-11
ER

PT J
AU Warhadpande, M
   Sainz, K
   Jacobson, MS
AF Warhadpande, Maitreyi
   Sainz, Katelyn
   Jacobson, Marc S.
TI Effects of the COVID-19 Pandemic on Pediatric and Adolescent ASCVD Risk
   Factors
SO CURRENT ATHEROSCLEROSIS REPORTS
LA English
DT Review
DE Atherosclerosis; COVID-19; Adolescent obesity; Hypercholesterolemia;
   Diabetes; Metabolic syndrome
ID UNITED-STATES
AB Purpose of ReviewIn this review, we provide insight into and raise awareness of the impact of the COVID-19 pandemic on the prevalence of acquired atherosclerotic cardiovascular disease (ASCVD) risk factors in adolescents. We highlight data that could be used to guide the response to a future pandemic with the goal of reducing premature cardiovascular disease (CVD)-related morbidity and premature mortality.Recent FindingsDuring the global COVID-19 pandemic, many individuals, including youth, voluntarily or were mandated to alter the usual lifestyle in order to limit exposure and reduce the spread of the virus. Some of these changes resulted in unintended consequences, particularly acquisition of risk factors such as excessive weight gain, insulin resistance/diabetes, and dyslipidemia, commonly associated with ASCVD. A study from China examined changes in the prevalence of obesity and found a 2.4% rise attributable to the pandemic. Adequate daily physical activity plays an important role in ASCVD risk reduction. A systematic review and meta-analysis showed a 20% (90% CI, -34 to -4%) reduction in physical activity from before vs. during the COVID-19 pandemic. Another study of patients with type 2 diabetes found the mean HbA1c was significantly elevated during the COVID-19 pandemic (7.53 & PLUSMN; 1.02% in 2020) compared with the previous 2 years. In addition, there has been an alarming rise of childhood mental health concerns and suicide during the pandemic. Early identification and optimum management of CVD risk factors play an important role helping prevent future cardiovascular disease.Following the rapid spread of the virus, the World Health Organization (WHO) officially declared COVID-19 a global pandemic on March 11th, 2020. In an attempt to avoid infection and reduce the spread of the virus, many alterations in lifestyle were adopted on an international scale. While necessary, these modifications resulted in many adverse unintended health consequences in children and adolescents. This paper reviews the impact of the pandemic and the associated lifestyle changes on the prevalence of acquired atherosclerotic cardiovascular disease (ASCVD) risk factors in youth. In addition to providing insight, we hope to raise awareness of the pandemic's impact, and highlight specific data that could be used to guide the response to a future pandemic.
C1 [Warhadpande, Maitreyi; Sainz, Katelyn; Jacobson, Marc S.] TMC Children, Tucson, AZ 85712 USA.
RP Warhadpande, M (corresponding author), TMC Children, Tucson, AZ 85712 USA.
EM Maitreyi2888@gmail.com; sainzkatelyn@gmail.com; Marc.jacobson@tmcaz.com
OI Warhadpande, Maitreyi/0000-0002-4422-2321
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NR 27
TC 6
Z9 6
U1 0
U2 1
PU CURRENT MEDICINE GROUP
PI PHILADELPHIA
PA 400 MARKET STREET, STE 700, PHILADELPHIA, PA 19106 USA
SN 1523-3804
EI 1534-6242
J9 CURR ATHEROSCLER REP
JI Curr. Atheroscleros. Rep.
PD SEP
PY 2023
VL 25
IS 9
BP 591
EP 596
DI 10.1007/s11883-023-01130-1
EA JUL 2023
PG 6
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA Q2WB2
UT WOS:001032757900001
PM 37470956
DA 2025-06-11
ER

PT J
AU Younossi, ZM
   Stepanova, M
   Younossi, I
   Racila, A
AF Younossi, Zobair M.
   Stepanova, Maria
   Younossi, Issah
   Racila, Andrei
TI Validation of Chronic Liver Disease Questionnaire for Nonalcoholic
   Steatohepatitis in Patients With Biopsy-Proven Nonalcoholic
   Steatohepatitis
SO CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
LA English
DT Article
DE PRO; Metabolic Syndrome; Quality Of Life; Fatty Liver
ID QUALITY-OF-LIFE; REPORTED OUTCOMES; SOFOSBUVIR; EPIDEMIOLOGY;
   VELPATASVIR; PREVALENCE; LEDIPASVIR; MANAGEMENT; MORTALITY; INFECTION
AB BACKGROUND & AIMS: The chronic liver disease questionnaire for nonalcoholic steatohepatitis (CLDQ-NASH) was developed in a systematic manner for assessment of patient-reported outcomes. This instrument collects data on 36 items grouped into 6 domains: abdominal symptoms, activity/energy, emotional health, fatigue, systemic symptoms, and worry. We aimed to validate the CLDQ-NASH in a large group of patients with NASH.
   METHODS: We collected data from patients with biopsy-proven NASH enrolled in 2 international phase 3 trials of selonsertib (NCT03053050 and NCT03053063). Our final analysis comprised 1667 patients who completed the CLDQ-NASH (age, 58 +/- 9 y; 40% male; 52% with cirrhosis; and 69% with type 2 diabetes). The CLDQ-NASH was administered before treatment initiation. A standard patient-reported outcome instrument validation pipeline with internal consistency and validity assessment was applied.
   RESULTS: The domains of CLDQ-NASH showed good to excellent internal consistency: the Cronbach's alpha values were 0.80 to 0.94 and item-to-own-domain correlations were greater than 0.50 for 33 of 36 items. All items correlated to the greatest extent with their own domains (discriminant validity). Known-group validity tests indicated that the instrument consistently discriminated between patients with NASH based on the presence of cirrhosis (vs bridging fibrosis; all but 1 P value < .02), obesity (all but 1 P value < .001), psychiatric comorbidities (all P values < .0001), fatigue (all P values < .001), and type 2 diabetes (all but 1 P value < .01). Of the CLDQ-NASH domains, the highest correlated domains with the Short Form-36 were as follows: physical functioning for activity (rho = 0.70), mental health for emotional (rho = 0.72), vitality for fatigue (rho = 0.75), and body pain for systemic (rho = 0.72) (all P values < .0001). In contrast, the domains of abdominal and worry, which are disease-specific, did not correlate with the domains in the Short Form-36 (all rho <= 0.50).
   CONCLUSIONS: We validated the CLDQ-NASH by an analysis of data from 1667 patients with biopsy-proven NASH enrolled in phase 3 trials, observing excellent psychometric characteristics of the instrument.
C1 [Younossi, Zobair M.; Racila, Andrei] Inova Fairfax Hosp, Dept Med, Ctr Liver Dis, Falls Church, VA USA.
   [Younossi, Zobair M.] Inova Hlth Syst, Betty & Guy Beatty Ctr Integrated Res, Falls Church, VA USA.
   [Stepanova, Maria; Younossi, Issah; Racila, Andrei] Ctr Outcomes Res Liver Dis, Washington, DC USA.
C3 Inova Fairfax Hospital; Inova Health System
RP Younossi, ZM (corresponding author), Betty & Guy Beatty Ctr Integrated Res, Claude Moore Hlth Educ & Res Bldg,3300 Gallows Rd, Falls Church, VA 22042 USA.
EM zobair.younossi@inova.org
RI Younossi, Zobair M./JRY-9916-2023; Stepanova, Maria/V-5513-2019
FU Center for Outcomes Research in Liver Diseases (Washington, DC); Gilead
   Sciences (Foster City, CA)
FX The study was partially funded by the Center for Outcomes Research in
   Liver Diseases (Washington, DC) and Gilead Sciences (Foster City, CA).
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NR 39
TC 39
Z9 39
U1 0
U2 8
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1542-3565
EI 1542-7714
J9 CLIN GASTROENTEROL H
JI Clin. Gastroenterol. Hepatol.
PD SEP
PY 2019
VL 17
IS 10
BP 2093
EP +
DI 10.1016/j.cgh.2019.01.001
PG 11
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA IS5UE
UT WOS:000482217300033
PM 30639779
DA 2025-06-11
ER

PT J
AU Camilla, L
   Daniel, B
   Maritta, V
AF Camilla, Langstedt
   Daniel, Bressington
   Maritta, Valimaki
TI Nurses' and patients' perceptions of physical health screening for
   patients with schizophrenia spectrum disorders: a qualitative study
SO BMC NURSING
LA English
DT Article
DE Schizophrenia spectrum disorder; Severe mental illness; Physical health;
   Screening; Monitoring; Interview; Focus group; Qualitative
ID SERIOUS MENTAL-ILLNESS; URINARY-TRACT-INFECTIONS; METABOLIC SYNDROME;
   FOCUS GROUPS; PEOPLE; CARE; INTERVIEWS; PREVALENCE; INTERVENTION;
   MORTALITY
AB Background Despite worldwide concern about the poor physical health of patients with schizophrenia spectrum disorders (SSD), physical health screening rates are low. This study reports nurses' and patients' experiences of physical health screening among people with SSD using the Finnish Health Improvement Profile (HIP-F) and their ideas for implementation improvements.Methods A qualitative exploratory study design with five group interviews with nurses (n = 15) and individual interviews with patients with SSD (n = 8) who had experience using the HIP-F in psychiatric outpatient clinics. Inductive content analysis was conducted.Results Two main categories were identified. First, the characteristics of the HIP-F were divided into the subcategories of comprehensive nature, facilitating engagement, interpretation and rating of some items and duration of screening. Second, suggestions for the implementation of physical health screening consisted of two subcategories: improvements in screening and ideas for practice. Physical health screening was felt to increase the discussion and awareness of physical health and supported health promotion. The HIP-F was found to be a structured, comprehensive screening tool that included several items that were not otherwise assessed in clinical practice. The HIP-F was also considered to facilitate engagement by promoting collaboration in an interactive way. Despite this, most of the nurses found the HIP-F to be arduous and too time consuming, while patients found the HIP-F easy to use. Nurses found some items unclear and infeasible, while patients found all items feasible. Based on the nurses' experiences, screening should be clear and easy to interpret, and condensation and revision of the HIP-F tool were suggested. The patients did not think that any improvements to the HIP-F were needed for implementation in clinical settings.Conclusions Patients with schizophrenia spectrum disorders are willing to participate in physical health screening. Physical health screening should be clear, easy to use and relatively quick. With this detailed knowledge of perceptions of screening, further research is needed to understand what factors affect the fidelity of implementing physical health screening in clinical mental health practice and to gain an overall understanding on how to improve such implementation.
C1 [Camilla, Langstedt; Maritta, Valimaki] Univ Turku, Fac Med, Dept Nursing, Kiinamyllynkatu 10,Medisiina B, Turku 20520, Finland.
   [Daniel, Bressington] Charles Darwin Univ, Fac Hlth, Mental Hlth, Casuarina, Australia.
   [Daniel, Bressington] Chiang Mai Univ, Fac Nursing, 110-406 Inthawaroros Rd, Chiang Mai, Thailand.
   [Maritta, Valimaki] Univ Helsinki, Sch Publ Hlth, Helsinki, Finland.
C3 University of Turku; Charles Darwin University; Chiang Mai University;
   University of Helsinki
RP Camilla, L (corresponding author), Univ Turku, Fac Med, Dept Nursing, Kiinamyllynkatu 10,Medisiina B, Turku 20520, Finland.
EM camaka@utu.fi
RI Välimäki, Maritta/JTV-2461-2023; Bressington, Daniel/G-2789-2017;
   Valimaki, Maritta/E-7092-2017
OI Bressington, Daniel/0000-0003-0951-2208; Valimaki,
   Maritta/0000-0001-7234-2454; Langstedt, Camilla/0000-0002-5812-5768
FU Helsinki University Hospitals (HUH) Nursing Research Center (NRC)
FX We would like to thank all patients and nurses for their indispensable
   assistance in conducting this research.
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NR 90
TC 1
Z9 1
U1 0
U2 3
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1472-6955
J9 BMC NURS
JI BMC Nurs.
PD MAY 11
PY 2024
VL 23
IS 1
AR 321
DI 10.1186/s12912-024-01980-3
PG 14
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA QI8M3
UT WOS:001220338100003
PM 38734609
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Looijmans, A
   Jörg, F
   Schoevers, RA
   Bruggeman, R
   Stolk, RP
   Corpeleijn, E
AF Looijmans, Anne
   Jorg, Frederike
   Schoevers, Robert A.
   Bruggeman, Richard
   Stolk, Ronald P.
   Corpeleijn, Eva
TI Changing the obesogenic environment of severe mentally ill residential
   patients: ELIPS, a cluster randomised study design
SO BMC PSYCHIATRY
LA English
DT Article
DE Severe mental illness; Residential patients; Cardiometabolic health;
   Obesogenic environment; Diet; Physical activity; Pragmatic trial
ID WEIGHT-LOSS INTERVENTION; EDUCATIONAL INTERVENTION; METABOLIC SYNDROME;
   PHYSICAL-ACTIVITY; BODY-COMPOSITION; SCHIZOPHRENIA; ILLNESS; TRIALS;
   STATEMENT; VALIDITY
AB Background: Severe mentally ill (SMI) patients have a reduced life expectancy of 13-30 years compared to the general population, largely due to an increased risk of cardiovascular mortality. Unhealthy lifestyle behaviours in SMI patients contribute to this increased risk. The obesogenic living environment of patients in residential facilities may even pose an extra risk. Although several studies have shown positive effects of lifestyle interventions on SMI patients' weight status, studies including residential patients and their obesogenic environment are scarce. This paper describes the Effectiveness of Lifestyle Interventions in PSychiatry trial (ELIPS). The goal of this trial is to improve cardiometabolic health in severe mentally ill residential patients by addressing the obesogenic environment.
   Methods/design: The ELIPS study is a multi-site cluster randomised controlled trial (RCT) based on the principles of a pragmatic RCT. All residential and long-term clinical care teams of two large mental health care organisations in the North of the Netherlands serving SMI patients are invited to participate. The intervention is aimed at team level. Lifestyle coaches first develop a team specific lifestyle plan that tailors the ELIPS goals and protocol and then train teams on how to create a healthy environment and stimulate healthy behaviours in patients. After three months, teams take over the intervention after they have set out goals to achieve in the following nine months. In this phase, adherence to the lifestyle plan and pre-set goals is monitored. Patients in the control arm receive care as usual. Primary outcome measure is waist circumference at three and 12 months after baseline.
   Discussion: ELIPS is different from previously published lifestyle intervention studies in three ways. First, it follows the principles of a pragmatic design, which enables the examination of effects in everyday practice. Second, by implementing the intervention at team level, we expect lifestyle activities to be maintained when interventionists leave. Last, by targeting the obesogenic environment we create a prerequisite for any sustainable health improvement, as patients can only make healthy choices in a healthy living environment.
C1 [Looijmans, Anne; Stolk, Ronald P.; Corpeleijn, Eva] Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, NL-9700 RB Groningen, Netherlands.
   [Jorg, Frederike; Schoevers, Robert A.; Bruggeman, Richard] Univ Groningen, Univ Med Ctr Groningen, Dept Psychiat, NL-9700 RB Groningen, Netherlands.
   [Jorg, Frederike] Friesland Mental Hlth Serv, Res Dept, Leeuwarden, Netherlands.
C3 University of Groningen; University of Groningen
RP Looijmans, A (corresponding author), Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, FA 40,POB 30-001, NL-9700 RB Groningen, Netherlands.
EM A.Looijmans@umcg.nl
RI Jörg, Frederike/B-1325-2014; Stolk, Ronald/B-2341-2013
OI Bruggeman, Richard/0000-0002-3238-8471; Schoevers, Robert
   A/0000-0003-0760-9866; Corpeleijn, Eva/0000-0002-2974-3305; Stolk,
   Ronald/0000-0002-0518-1205
FU ZonMW [171101002]
FX Funding for this study is provided by ZonMW, Grant 171101002.
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NR 44
TC 4
Z9 5
U1 0
U2 18
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-244X
J9 BMC PSYCHIATRY
JI BMC Psychiatry
PD NOV 25
PY 2014
VL 14
AR 293
DI 10.1186/s12888-014-0293-9
PG 11
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA AW1DN
UT WOS:000346030900001
PM 25422085
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Richardson, A
   Richard, L
   Gunter, K
   Derrett, S
AF Richardson, Amy
   Richard, Lauralie
   Gunter, Kathryn
   Derrett, Sarah
TI Interventions to integrate care for people with serious mental illness
   and substance use disorders: a systematic scoping review protocol
SO BMJ OPEN
LA English
DT Review
ID MAJOR DEPRESSIVE DISORDER; BIPOLAR DISORDER; HEALTH-CARE; METABOLIC
   SYNDROME; PHYSICAL-ACTIVITY; MEDICAL-CARE; SCHIZOPHRENIA; INDIVIDUALS;
   PREVALENCE; ABUSE
AB Introduction People with serious mental illness (SMI) and/or substance use disorders (SUDs) have an elevated risk of premature mortality compared with the general population. This has been attributed to higher rates of chronic illness among these individuals, but also to inequities in healthcare access and treatment. Integrated care has the potential to improve the health of people with SMI/SUDs. The aims of this scoping review are to: (1) identify empirical investigations of interventions designed to integrate care for people with SMI/SUDs; (2) describe the underlying theories, models and frameworks of integrated care that informed their development; and (3) determine the degree to which interventions address dimensions of a comprehensive and validated framework of integrated care.
   Methods and analysis Guidelines for best practice and reporting of scoping reviews will be followed using the framework of Arksey and O'Malley and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses scoping review checklist. An iterative and systematic search of peer-reviewed publications reporting empirical research findings will be conducted. This literature will be identified by searching five databases: Medline (Ovid), PsycINFO, CINAHL, Embase (Ovid) and Scopus. The search will be restricted to articles published between January 2000 and April 2019. Two reviewers will independently screen publications in two successive stages of title and abstract screening, followed by full-text screening of eligible publications. A tabular summary and narrative synthesis will be completed using data extracted from each included study. A framework synthesis will also be conducted, with descriptions of interventions mapped against a theoretical framework of integrated care.
   Ethics and dissemination This review will identify the extent and nature of empirical investigations evaluating interventions to integrate care for people with SMI/SUDs. Ethical approval was not required. A team of relevant stakeholders, including people with lived experience of mental health conditions, has been established. This team will be engaged throughout the review and will ensure that the findings are widely disseminated. Dissemination will include publication of the review in a peer-reviewed journal. The review protocol has been registered through Open Science Framework and can be accessed at https://osf.io/njkph/
C1 [Richardson, Amy; Derrett, Sarah] Univ Otago, Dunedin Sch Med, Dept Prevent & Social Med, Dunedin, New Zealand.
   [Richard, Lauralie] Univ Otago, Dunedin Sch Med, Dept Gen Practice & Rural Hlth, Dunedin, New Zealand.
   [Gunter, Kathryn] Univ Chicago, Dept Med, Chicago Ctr Diabet Translat Res, 5841 S Maryland Ave, Chicago, IL 60637 USA.
C3 University of Otago; University of Otago; University of Chicago
RP Richardson, A (corresponding author), Univ Otago, Dunedin Sch Med, Dept Prevent & Social Med, Dunedin, New Zealand.
EM amy.richardson@otago.ac.nz
OI Richardson, Amy/0000-0003-4776-3059
FU University of Otago
FX This research is funded by a University of Otago Research Grant (NZD
   $34743).
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NR 52
TC 2
Z9 2
U1 0
U2 10
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2044-6055
J9 BMJ OPEN
JI BMJ Open
PD OCT
PY 2019
VL 9
IS 10
AR e031122
DI 10.1136/bmjopen-2019-031122
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA KK6XG
UT WOS:000512882200185
PM 31666268
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Alanazi, SM
   Alsaqer, RA
   Alsaeed, FI
   Almakhaytah, RM
   Buwashl, NT
   Mohamed, ME
   Younis, NS
AF Alanazi, S. M.
   Alsaqer, R. A.
   Alsaeed, F. I.
   Almakhaytah, R. M.
   Buwashl, N. T.
   Mohamed, M. E.
   Younis, N. S.
TI Studying the actions of sage and thymoquinone combination on metabolic
   syndrome induced by high-fat diet in rats
SO EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
LA English
DT Article
DE Thymoquinone; Sage; High fat diet; Blood pres-sure
ID SALVIA-OFFICINALIS L.; OXIDATIVE STRESS; INSULIN-RESISTANCE; INDUCED
   OBESITY; BLOOD-PRESSURE; ESSENTIAL OILS; LIPID PROFILE; COMMON SAGE;
   ANTIOXIDANT; SUPPLEMENTATION
AB OBJECTIVE: High-fat diet is one of the most imperative risk factors for cardio-vascular disorders. Thymoquinone (TQ) is one of the active pharmacological components of Nigella sativa (black cumin). Salvia officinalis L. (sage) has been demonstrated to have diverse pharmacological actions. The main objective of this study was to determine the effects of sage and TQ combination on hyperglycemia, oxida-tive stress, blood pressure, and lipid profile in rats fed with a high-fat diet (HFD).MATERIALS AND METHODS: Wistar male rats were divided into five groups; normal di-et (ND) and HFD, in which rats were fed with a normal diet or HFD for 10 weeks, respectively. In HFD + sage group, animals were administered sage essential oil (0.052 ml/kg) orally along with HFD. In HFD + TQ group, rats were administered TQ (50 mg/kg) orally with HFD. In HF + sage + TQ group, animals received sage + TQ along with HFD. Blood glucose (BGL) and Fast serum in-sulin (FSI) levels, oral glucose tolerance test, blood pressure, liver function tests, plasma, and hepatic oxidative stress markers, antioxidant enzymes, and glutathione content, and lipid pro-file were measured.RESULTS: Sage and TQ combination de-creased the final body weight, weight gain, BGL, FSI, and Homeostasis Model Assessment -Insu-lin Resistance (HOMA-IR). The combination also lowered systolic and diastolic arterial pressures and liver function enzymes. The combination de-terred lipid peroxidation, advanced protein oxi-dation product, and nitric oxide amplification, as well as restoring the superoxide dismutase, cata-lase activities, and glutathione content in plasma and hepatic tissue. Sage and TQ combination re-duced the plasma total cholesterol (TC), triglycer-ide (TG), and low-density lipoprotein (LDL) levels and amplified high-density lipoprotein (HDL).CONCLUSIONS: The results of the current study verified that sage essential oil, together with TQ exhibited hypoglycemic, hypolipidem-ic, and antioxidant actions and thus could be a valuable addition to diabetes management.
C1 [Alanazi, S. M.; Alsaqer, R. A.; Alsaeed, F. I.; Almakhaytah, R. M.; Buwashl, N. T.; Mohamed, M. E.; Younis, N. S.] King Faisal Univ, Coll Clin Pharm, Dept Pharmaceut Sci, Al Hasa, Saudi Arabia.
C3 King Faisal University
RP Younis, NS (corresponding author), King Faisal Univ, Coll Clin Pharm, Dept Pharmaceut Sci, Al Hasa, Saudi Arabia.
EM nyounis@kfu.edu.sa
RI Younis, Nancy/GSO-3511-2022; Mohamed, Maged/M-3993-2016
OI Alsaqer, Riam/0009-0006-5300-2415
FU Deanship of Scientific Re- search, Vice Presidency for Graduate Studies
   and Scientif- ic Research, King Faisal University, Saudi Arabia [966]
FX Acknowledgements Funding This work was supported by the Deanship of
   Scientific Re- search, Vice Presidency for Graduate Studies and
   Scientif- ic Research, King Faisal University, Saudi Arabia [Grant No.
   966] ..
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NR 75
TC 3
Z9 3
U1 2
U2 5
PU VERDUCI PUBLISHER
PI ROME
PA VIA GREGORIO VII, ROME, 186-00165, ITALY
SN 1128-3602
J9 EUR REV MED PHARMACO
JI Eur. Rev. Med. Pharmacol. Sci.
PY 2023
VL 27
IS 6
BP 2404
EP 2418
PG 15
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA D9OA0
UT WOS:000971936600026
PM 37013759
DA 2025-06-11
ER

PT J
AU Lee, J
   Lee, S
   Zhang, HR
   Hill, MA
   Zhang, CH
   Park, Y
AF Lee, Jonghae
   Lee, Sewon
   Zhang, Hanrui
   Hill, Michael A.
   Zhang, Cuihua
   Park, Yoonjung
TI Interaction of IL-6 and TNF-α contributes to endothelial dysfunction in
   type 2 diabetic mouse hearts
SO PLOS ONE
LA English
DT Article
ID INSULIN-RESISTANCE; NITRIC-OXIDE; INTERLEUKIN-6 IMPAIRS; METABOLIC
   SYNDROME; OXIDATIVE STRESS; ANGIOTENSIN-II; MICE; OBESITY; RISK; CELLS
AB Objectives
   Inflammatory cytokines, such as tumor necrosis factor-a (TNF-alpha) and interleukin-6 (IL-6), are individually considered as important contributors to endothelial dysfunction in obesity and type 2 diabetes (T2D). However, their interactions in coronary arteriole endothelial dysfunction are uncertain. Therefore, this study aimed to determine the effects of TNF-alpha and IL-6 interactions on coronary endothelial dysfunction in experimental T2D.
   Methods
   The studies used wild type (WT), diabetic mice (db/db), db/db null for TNF (db(TNF-)/db(TNF-)), and db/db mice treated with neutralizing antibody to IL-6 (anti-IL-6). Endothelium-dependent (acetylcholine [ACh], or luminal flow-induced shear stress) and endothelium-independent (sodium nitroprusside [SNP]) vasodilation of isolated and pressurized coronary arterioles were determined. Quantitative PCR, Western blot, and immunofluorescence staining were utilized for mechanistic studies.
   Results
   Relative to WT, arteriolar dilation to both ACh and flow was attenuated in db/db mice and db(TNF-)/db(TNF-). Treatment of db(TNF-)/db(TNF-) and db/db mice with anti-IL-6 improved arteriolar dilation compared to db/db mice. Immunofluorescence staining illustrated localization of IL-6 within the endothelial cells of coronary arterioles. In db/db mice, mRNA and protein expression of IL-6 and superoxide (0 (2)similar to) production were higher, but reduced by anti-IL-6 treatment. Also, in db/db mice, mRNA and protein expression of TNF-alpha suppressed by the anti-IL-6 treatment and the reduced expression of mRNA and protein expression of IL-6 by the genetic deletion of TNF-alpha both supported a reciprocal regulation between TNF-alpha and IL-6. Superoxide dismutase 2 (SOD2) expression and phosphorylation of eNOS (p-eNOS/eNOS) were lower in db/db mice coronary arterioles and were restored in db/db+Anti-IL-6 and db (TNF-)/db (TNF-) mice.
   Conclusion
   The interactions between TNF-alpha and IL-6 exacerbate oxidative stress and reduce phosphorylation of eNOS, thereby contributing to coronary endothelial dysfunction in T2D mice.
C1 [Lee, Jonghae; Park, Yoonjung] Univ Houston, Dept Hlth & Human Performance, Houston, TX 77004 USA.
   [Lee, Sewon; Zhang, Hanrui; Hill, Michael A.; Zhang, Cuihua; Park, Yoonjung] Univ Missouri, Dalton Cardiovasc Res Ctr, Columbia, MO 65211 USA.
   [Lee, Sewon; Zhang, Hanrui; Hill, Michael A.; Zhang, Cuihua] Univ Missouri, Med Pharmacol, Columbia, MO USA.
   [Lee, Sewon] Incheon Natl Univ, Div Sport Sci, Incheon, South Korea.
   [Lee, Sewon] Incheon Natl Univ, Sport Sci Inst, Incheon, South Korea.
   [Zhang, Hanrui] Columbia Univ, Med Ctr, Div Cardiol, Dept Med, New York, NY USA.
   [Zhang, Cuihua] Univ Missouri, Dept Internal Med, Columbia, MO USA.
   [Zhang, Cuihua] Univ Missouri, Physiol & Nutr Sci, Columbia, MO USA.
C3 University of Houston System; University of Houston; University of
   Missouri System; University of Missouri Columbia; University of Missouri
   System; University of Missouri Columbia; Incheon National University;
   Incheon National University; Columbia University; University of Missouri
   System; University of Missouri Columbia; University of Missouri System;
   University of Missouri Columbia
RP Park, Y (corresponding author), Univ Houston, Dept Hlth & Human Performance, Houston, TX 77004 USA.; Park, Y (corresponding author), Univ Missouri, Dalton Cardiovasc Res Ctr, Columbia, MO 65211 USA.
EM ypark10@uh.edu
RI Hill, Michael/AAV-5350-2020; Park, Yoonjung/LRU-1163-2024; Lee,
   Sewon/C-8432-2016
OI Hill, Michael/0000-0002-4455-2072; Lee, Sewon/0000-0002-6179-5156; Lee,
   Jonghae/0000-0002-1182-9653; Zhang, Hanrui/0000-0001-8655-938X
FU National Heart, Lung, and Blood Institute (NHLBI) [R01-HL077566,
   R01-HL085119]; American Heart Association Scientist Development Grant
   [110350047A]
FX This work was supported by the National Heart, Lung, and Blood Institute
   (NHLBI, R01-HL077566) to C.Z (Deceased 2011) and M.A.H
   (http://dalton.missouri.edu/investigators/hillmi.php); National Heart,
   Lung, and Blood Institute (NHLBI, R01-HL085119) to C.Z and M.A.H;
   American Heart Association Scientist Development Grant (110350047A) to
   C.Z. The funders had no role in study design, data collection and
   analysis, decision to publish, or preparation of the manuscript.
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NR 47
TC 99
Z9 108
U1 2
U2 10
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD NOV 2
PY 2017
VL 12
IS 11
AR e0187189
DI 10.1371/journal.pone.0187189
PG 17
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA FL6FI
UT WOS:000414340200053
PM 29095915
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Ittner, AA
   Bertz, J
   Chan, TYB
   van Eersel, J
   Polly, P
   Ittner, LM
AF Ittner, Arne A.
   Bertz, Josefine
   Chan, Tse Yan Becky
   van Eersel, Janet
   Polly, Patsie
   Ittner, Lars M.
TI The nucleotide exchange factor SIL1 is required for glucose-stimulated
   insulin secretion from mouse pancreatic beta cells in vivo
SO DIABETOLOGIA
LA English
DT Article
DE Endoplasmic reticulum; Glucose-stimulated insulin secretion; High-fat
   diet; Islet size; Pancreatic islets of Langerhans; Proinsulin;
   Streptozotocin
ID MARINESCO-SJOGREN-SYNDROME; ENDOPLASMIC-RETICULUM STRESS; HIGH-FAT DIET;
   METABOLIC-DISORDERS; ALZHEIMERS-DISEASE; DIABETES-MELLITUS;
   QUALITY-CONTROL; TAU PATHOLOGY; PROINSULIN; PROTEIN
AB Aims/hypothesis Regulation of insulin secretion along the secretory pathway is incompletely understood. We addressed the expression of SIL1, a nucleotide exchange factor for the endoplasmic reticulum (ER) chaperone glucose-regulated protein 78 kD (GRP78), in pancreatic beta cells and investigated whether or not SIL1 is involved in beta cell function.
   Methods SIL1 expression was analysed by immunoblotting and immunofluorescence. Metabolic and islet variables, including glucose tolerance, beta cell mass, insulin secretion, islet ultrastructure, insulin content and levels of ER stress marker proteins, were addressed in Sil1 knockout (Sil1(-/-)) mice. Insulin, proinsulin and C-peptide release was addressed in Sil1(-/-) islets, and SIL1 overexpression or knockdown was explored in MIN6 cells in vitro. Models of type 1 diabetes and insulin resistance were induced in Sil1(-/-) mice by administration of streptozotocin (STZ) and a high-fat diet (HFD), respectively.
   Results We show that SIL1 is expressed in pancreatic beta cells and is required for islet insulin content, islet sizing, glucose tolerance and glucose-stimulated insulin secretion in vivo. Levels of pancreatic ER stress markers are increased in Sil1(-/-) mice, and Sil1(-/-) beta cell ER is ultrastructurally compromised. Isolated Sil1(-/-) islets show lower proinsulin and insulin content and impaired glucose-stimulated insulin secretion. Modulation of SIL1 protein levels in MIN6 cells correlates with changes in insulin content and secreted insulin. Furthermore, Sil1(-/-) mice are more susceptible to STZ-induced type 1 diabetes with increased apoptosis. Upon HFD feeding, Sil1(-/-) mice show markedly lower insulin secretion and exacerbated glucose intolerance compared with control mice. Surprisingly, however, HFD-fed Sil1(-/-) mice display pronounced islet hyperplasia with low amounts of insulin in total pancreas.
   Conclusions/interpretation These results reveal a novel role for the nucleotide exchange factor SIL1 in pancreatic beta cell function under physiological and disease conditions such as diabetes and the metabolic syndrome.
C1 [Ittner, Arne A.; Bertz, Josefine; van Eersel, Janet; Polly, Patsie; Ittner, Lars M.] Univ New S Wales, Sch Med Sci, Sydney, NSW 2052, Australia.
   [Ittner, Arne A.; Bertz, Josefine; Chan, Tse Yan Becky; van Eersel, Janet; Ittner, Lars M.] Univ Sydney, Fac Med, Sydney, NSW 2006, Australia.
   [Ittner, Lars M.] Neurosci Res Australia, Sydney, NSW, Australia.
   [Polly, Patsie] Univ New S Wales, Dept Pathol, Sydney, NSW 2052, Australia.
C3 University of New South Wales Sydney; University of Sydney; Neuroscience
   Research Australia; University of New South Wales Sydney
RP Ittner, AA (corresponding author), Univ New S Wales, Sch Med Sci, Bot St, Sydney, NSW 2052, Australia.
EM a.ittner@unsw.edu.au
RI Ittner, Arne/ABD-3072-2021; van Eersel, Janet/AAZ-4197-2020
OI Ittner, Lars/0000-0001-6738-3825; van Eersel, Janet/0000-0002-1354-6171;
   Ittner, Arne/0000-0001-5244-6897; Bertz, Josefine/0000-0001-7030-2096
FU National Health and Medical Research Council (NHMRC); Australian
   Research Council (ARC); University of New South Wales
FX The research was supported by funding from the National Health and
   Medical Research Council (NHMRC), the Australian Research Council (ARC)
   and the University of New South Wales. LMI is a NHMRC Senior Research
   Fellow.
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NR 40
TC 22
Z9 25
U1 0
U2 16
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0012-186X
EI 1432-0428
J9 DIABETOLOGIA
JI Diabetologia
PD JUL
PY 2014
VL 57
IS 7
BP 1410
EP 1419
DI 10.1007/s00125-014-3230-z
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA AJ2OZ
UT WOS:000337498700019
PM 24733160
DA 2025-06-11
ER

PT J
AU Liu, HW
   Zhang, F
   Fan, P
   Bai, H
   Zhang, JX
   Wang, Y
AF Liu, Hong-Wei
   Zhang, Feng
   Fan, Ping
   Bai, Huai
   Zhang, Jin-Xia
   Wang, Ying
TI Effects of apolipoprotein E genotypes on metabolic profile and oxidative
   stress in south-west Chinese women with polycystic ovary syndrome
SO EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
LA English
DT Article
DE Apolipoprotein E; Genetic polymorphism; Metabolism; Oxidative stress;
   Polycystic ovary syndrome
ID CARDIOVASCULAR-DISEASE RISK; INSULIN-RESISTANCE; E POLYMORPHISM; GENE;
   ASSOCIATION; DYSLIPIDEMIA; INFLAMMATION; METAANALYSIS; ALLELE; APOE
AB Objective: Apolipoprotein (APO) E genetic polymorphism plays an important role in lipid and lipoprotein metabolism, and has been shown to be associated with the risk of metabolic and cardio-cerebrovascular diseases and late-onset Alzheimer's disease. It is not clear, however, whether there are any relationships between the APOE genotypes and PCOS in Chinese women. The aim of this study was to investigate the relationship between APOE genotypes and the risk of polycystic ovary syndrome (PCOS) and to evaluate the effects of the genotypes on metabolic profile and oxidative stress in south-west Chinese women.
   Study design: A total of 625 patients with PCOS based on the Rotterdam consensus criteria and 514 control women from a population of Chinese Han nationality in the Chengdu area were studied during 2006-2012. APOE genotypes were determined by PCR and restriction fragment length polymorphism analysis. Clinical and metabolic parameters, serum malondialdehyde concentration, and total antioxidant capacity were analyzed.
   Results: No significant differences were found in the frequencies of APOE genotypes (E2/2, E2/3, E2/4, E3/3, E3/4, E4/4) and alleles (epsilon 2, epsilon 3, epsilon 4) between PCOS and control groups. Compared with 63 homozygotes (APOE3/3), however, epsilon 2 carriers (APOE2/2 + APOE2/3 + APOE2/4) had significantly higher body mass index, waist circumference and waist-to-hip ratio, a more adverse glucose and insulin metabolic profile, lower high density lipoprotein (HDL)-cholesterol (C) and APOA1 levels, higher triglyceride (TG)/HDL-C ratio and prevalence of metabolic syndrome (MS), whereas 64 carriers (APOE3/4 + APOE4/4) had higher total cholesterol (TC) and low density lipoprotein (LDL)-C levels in patients with PCOS.
   Conclusions: In a cohort of south-west Chinese women, there were no significant associations between any APOE genotype and PCOS. The APOE epsilon 2 allele seems to be related to abdominal obesity, insulin resistance and MS in PCOS women. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
C1 [Liu, Hong-Wei; Zhang, Feng; Wang, Ying] Sichuan Univ, West China Univ Hosp 2, Dept Obstet & Gynecol, Chengdu 610041, Sichuan, Peoples R China.
   [Fan, Ping; Bai, Huai; Zhang, Jin-Xia] Sichuan Univ, West China Univ Hosp 2, Lab Genet Dis & Perinatal Med, Chengdu 610041, Sichuan, Peoples R China.
   [Fan, Ping; Bai, Huai; Zhang, Jin-Xia] Sichuan Univ, West China Univ Hosp 2, Key Lab Obstet & Gynecol & Pediat Dis & Birth Def, Minist Educ, Chengdu 610041, Sichuan, Peoples R China.
C3 Sichuan University; Sichuan University; Ministry of Education - China;
   Sichuan University
RP Fan, P (corresponding author), Sichuan Univ, West China Univ Hosp 2, Lab Genet Dis & Perinatal Med, Chengdu 610041, Sichuan, Peoples R China.
EM fanping15@yahoo.com.cn
RI Zhang, Zhiqiang/GLS-9612-2022
FU Chinese National Natural Science Foundation [81070463]; Program for
   Changjiang Scholars and Innovative Research Team in University
   [IRT0935]; West China Second Hospital of Sichuan University
FX We thank patients with PCOS and control women who donated blood samples
   for this study. We are thankful to You Li, De-Hua Wan, Qi Song, and Qin
   Su for work performed to support this study. This work was supported by
   Chinese National Natural Science Foundation (81070463), Program for
   Changjiang Scholars and Innovative Research Team in University
   (IRT0935), and Research Seed Fund from West China Second Hospital of
   Sichuan University (to H. Bai).
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NR 41
TC 21
Z9 27
U1 0
U2 10
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0301-2115
EI 1872-7654
J9 EUR J OBSTET GYN R B
JI Eur. J. Obstet. Gynecol. Reprod. Biol.
PD SEP
PY 2013
VL 170
IS 1
BP 146
EP 151
DI 10.1016/j.ejogrb.2013.04.016
PG 6
WC Obstetrics & Gynecology; Reproductive Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology; Reproductive Biology
GA 227OA
UT WOS:000325122000028
PM 23746632
DA 2025-06-11
ER

PT J
AU Alarcon, G
   Roco, J
   Medina, M
   Medina, A
   Peral, M
   Jerez, S
AF Alarcon, Gabriela
   Roco, Julieta
   Medina, Mirta
   Medina, Analia
   Peral, Maria
   Jerez, Susana
TI High fat diet-induced metabolically obese and normal weight rabbit model
   shows early vascular dysfunction: mechanisms involved
SO INTERNATIONAL JOURNAL OF OBESITY
LA English
DT Article
ID BODY-MASS INDEX; NITRIC-OXIDE; OXIDATIVE STRESS; ENDOTHELIAL
   DYSFUNCTION; CARDIOVASCULAR-DISEASE; ANGIOTENSIN-II; ACIDS;
   PATHOPHYSIOLOGY; INFLAMMATION; MODULATION
AB Background Obesity contributes significantly to the development and evolution of cardiovascular disease (CVD) which is believed to be mediated by oxidative stress, inflammation and endothelial dysfunction. However, the vascular health of metabolically obese and normal weight (MONW) individuals is not completely comprehended.
   Objectives The purpose of our study was to evaluate vascular function on the basis of a high fat diet (HFD)-MONW rabbit model.
   Subjects Twenty four male rabbits were randomly assigned to receive either a regular diet (CD, n = 12) or a high-fat diet (18% extra fat on the regular diet, HFD, n = 12) for 6 weeks.
   Results Body weight, TBARS and gluthathione serum levels were similar between the groups; fasting glucose, triglycerides, C reactive protein (CRP), visceral adipose tissue (VAT), triglyceride-glucose index (TyG index) were higher in the HFD group. Compared to CD, the HFD rabbits had glucose intolerance and lower HDL-cholesterol and plasma nitrites levels. Thoracic aortic rings from HFD rabbits exhibited: (a) a reduced acetylcholine-induced vasorelaxation; (b) a greater contractile response to norepinephrine and KCl; (c) an improved angiotensin II-sensibility. The HFD-effect on acetylcholineresponse was reversed by the cyclooxygenase-2 (COX-2) inhibitor (NS398) and the cyclooxygenase-1 inhibitor (SC560), and the HFD-effect on angiotensin II was reversed by NS398 and the TP receptor blocker (SQ29538). Immunohistochemistry and western blot studies showed COX-2 expression only in arteries from HFD rabbits.
   Conclusions Our study shows a positive pro-inflammatory status of HFD-induced MONW characterized by raised COX-2 expression, increase of the CRP levels, reduction of NO release and oxidative stress-controlled conditions in an early stage of metabolic alterations characteristic of metabolic syndrome. Endothelial dysfunction and increased vascular reactivity in MONW individuals may be biomarkers of early vascular injury. Therefore, the metabolic changes induced by HFD even in normal weight individuals may be associated to functional alterations of blood vessels.
C1 [Alarcon, Gabriela; Roco, Julieta; Peral, Maria; Jerez, Susana] UNT CONICET, INSIBIO, Inst Super Invest Biol, Av Independencia 1800, RA-4000 San Miguel De Tucuman, Tucuman, Argentina.
   [Medina, Mirta; Medina, Analia; Jerez, Susana] UNT, Fac Ciencias Nat, Miguel Lillo 205, RA-4000 San Miguel De Tucuman, Tucuman, Argentina.
   [Medina, Mirta; Medina, Analia; Jerez, Susana] UNT, Inst Miguel Lillo, Miguel Lillo 205, RA-4000 San Miguel De Tucuman, Tucuman, Argentina.
   [Medina, Analia] Univ Norte Santo Tomas Aquino, Fac Ciencias Salud, Av Presidente Peron 2085, RA-4107 Yerba Buena, Tucuman, Argentina.
   [Peral, Maria] UNT, Fac Med, Av Presidente Kirchner 1800, RA-4000 San Miguel De Tucuman, Tucuman, Argentina.
C3 Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET);
   Universidad Nacional de Tucuman; Universidad Nacional de Tucuman;
   Universidad Nacional de Tucuman; Miguel Lillo Foundation; Universidad
   Nacional de Tucuman
RP Jerez, S (corresponding author), UNT CONICET, INSIBIO, Inst Super Invest Biol, Av Independencia 1800, RA-4000 San Miguel De Tucuman, Tucuman, Argentina.; Jerez, S (corresponding author), UNT, Fac Ciencias Nat, Miguel Lillo 205, RA-4000 San Miguel De Tucuman, Tucuman, Argentina.; Jerez, S (corresponding author), UNT, Inst Miguel Lillo, Miguel Lillo 205, RA-4000 San Miguel De Tucuman, Tucuman, Argentina.
EM sjerez@herrera.unt.edu.ar
OI Alarcon, gabriela/0000-0001-8947-498X
FU Consejo de Investigaciones de la Universidad Nacional de Tucuman [PIUNT
   I521/1]; Consejo de Investigaciones Cientificas y Tecnicas de la
   Republica Argentina [CONICET PIP 215/14]; Universidad del Norte Santo
   Tomas de Aquino; INSIBIO (Instituto Superior de Investigaciones
   Biologicas)
FX This work was supported by grants from the Consejo de Investigaciones de
   la Universidad Nacional de Tucuman (PIUNT I521/1), Consejo de
   Investigaciones Cientificas y Tecnicas de la Republica Argentina
   (CONICET PIP 215/14), Universidad del Norte Santo Tomas de Aquino and
   Institutional funds from INSIBIO (Instituto Superior de Investigaciones
   Biologicas). We thank veterinary Rosa Alejandra Molina for bioterio
   management and Dr Liliana Sierra for her help in data collection.
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NR 48
TC 31
Z9 32
U1 1
U2 12
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0307-0565
EI 1476-5497
J9 INT J OBESITY
JI Int. J. Obes.
PD SEP
PY 2018
VL 42
IS 9
BP 1535
EP 1543
DI 10.1038/s41366-018-0020-6
PG 9
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA GV0KY
UT WOS:000445750700001
PM 29445240
DA 2025-06-11
ER

PT J
AU Crescenzo, R
   Cigliano, L
   Mazzoli, A
   Cancelliere, R
   Carotenuto, R
   Tussellino, M
   Liverini, G
   Iossa, S
AF Crescenzo, Raffaella
   Cigliano, Luisa
   Mazzoli, Arianna
   Cancelliere, Rosa
   Carotenuto, Rosa
   Tussellino, Margherita
   Liverini, Giovanna
   Iossa, Susanna
TI Early Effects of a Low Fat, Fructose-Rich Diet on Liver Metabolism,
   Insulin Signaling, and Oxidative Stress in Young and Adult Rats
SO FRONTIERS IN PHYSIOLOGY
LA English
DT Article
DE fructose diet; young and adult rats; inflammation; insulin resistance;
   hepatic oxidative stress
ID INTESTINAL INFLAMMATION; SWEETENED BEVERAGES; LIPID-METABOLISM;
   ADIPOSE-TISSUE; EXPRESSION; OBESITY; CONSUMPTION; RESISTANCE; PREVENTS;
   SUGAR
AB The increase in the use of refined food, which is rich in fructose, is of particular concern in children and adolescents, since the total caloric intake and the prevalence of metabolic syndrome are increasing continuously in these populations. Nevertheless, the effects of high fructose diet have been mostly investigated in adults, by focusing on the effect of a long-term fructose intake. Notably, some reports evidenced that even short-term fructose intake exerts detrimental effects on metabolism. Therefore, the aim of this study was to compare the metabolic changes induced by the fructose-rich diet in rats of different age, i.e., young (30 days old) and adult (90 days old) rats. The fructose-rich diet increased whole body lipid content in adult, but not in young rats. The analysis of liver markers of inflammation suggests that different mechanisms depending on the age might be activated after the fructose-rich diet. In fact, a pro-inflammatory gene-expression analysis showed just a minor activation of macrophages in young rats compared to adult rats, while other markers of low-grade metabolic inflammation (TNF-alpha, myeloperoxidase, lipocalin, haptoglobin) significantly increased. Inflammation was associated with oxidative damage to hepatic lipids in young and adult rats, while increased levels of hepatic nitrotyrosine and ceramides were detected only in young rats. Interestingly, fructose-induced hepatic insulin resistance was evident in young but not in adult rats, while whole body insulin sensitivity decreased both in fructose-fed young and adult rats. Taken together, the present data indicate that young rats do not increase their body lipids but are exposed to metabolic perturbations, such as hepatic insulin resistance and hepatic oxidative stress, in line with the finding that increased fructose intake may be an important predictor of metabolic risk in young people, independently of weight status. These results indicate the need of corrective nutritional interventions for young people and adults as well for the prevention of fructose-induced metabolic alterations.
C1 [Crescenzo, Raffaella; Cigliano, Luisa; Mazzoli, Arianna; Cancelliere, Rosa; Carotenuto, Rosa; Tussellino, Margherita; Liverini, Giovanna; Iossa, Susanna] Univ Naples Federico II, Dept Biol, Naples, Italy.
C3 University of Naples Federico II
RP Iossa, S (corresponding author), Univ Naples Federico II, Dept Biol, Naples, Italy.
EM susiossa@unina.it
RI Cigliano, Luisa/AEL-3260-2022; IOSSA, Susanna/O-1625-2016
OI IOSSA, Susanna/0000-0001-6103-718X; mazzoli, arianna/0000-0003-4096-443X
FU University of Naples Federico II
FX This work was supported by a grant from University of Naples Federico
   II-Ricerca Dip. 2015.
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NR 54
TC 34
Z9 36
U1 0
U2 9
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1664-042X
J9 FRONT PHYSIOL
JI Front. Physiol.
PD APR 26
PY 2018
VL 9
AR 411
DI 10.3389/fphys.2018.00411
PG 14
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA GE1JJ
UT WOS:000430972300001
PM 29755364
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Ferreira, MJ
   Silva, MPDF
   Dias, DD
   Bernardes, N
   Irigoyen, MC
   De Angelis, K
AF Ferreira, Maycon Junior
   Silva, Michel Pablo dos Santos Ferreira
   Dias, Danielle da Silva
   Bernardes, Nathalia
   Irigoyen, Maria Claudia
   De Angelis, Katia
TI Concurrent exercise training induces additional benefits to
   hydrochlorothiazide: Evidence for an improvement of autonomic control
   and oxidative stress in a model of hypertension and postmenopause
SO PLOS ONE
LA English
DT Article
ID BLOOD-PRESSURE VARIABILITY; RENIN-ANGIOTENSIN SYSTEM; BAROREFLEX
   SENSITIVITY; INSULIN-RESISTANCE; METABOLIC SYNDROME; NERVOUS-SYSTEM;
   TNF-ALPHA; THERAPY; SPIRONOLACTONE; DYSFUNCTION
AB ObjectiveThis study aimed to evaluate whether exercise training could contribute to a better modulation of the neurohumoral mechanisms linked to the pathophysiology of arterial hypertension (AH) in postmenopausal hypertensive rats treated with hydrochlorothiazide (HCTZ). MethodsFemale spontaneously hypertensive rats (SHR) (150-200g, 90 days old) were distributed into 5 hypertensive groups (n = 7-8 rats/group): control (C), ovariectomized (O), ovariectomized treated with HCTZ (OH), ovariectomized submitted to exercise training (OT) and ovariectomized submitted to exercise training and treated with HCTZ (OTH). Ovarian hormone deprivation was performed through bilateral ovariectomy. HCTZ (30mg/kg/day) and concurrent exercise training (3d/wk) were conducted lasted 8 weeks. Arterial pressure (AP) was directly recorded. Cardiac effort was evaluated using the rate-pressure product (RPP = systolic AP x heart rate). Vasopressin V1 receptor antagonist, losartan and hexamethonium were sequentially injected to evaluate the vasopressor systems. Inflammation and oxidative stress were evaluated in cardiac tissue. ResultsIn addition to the reduction in AP, trained groups improved RPP, AP variability, bradycardic (OT: -1.3 & PLUSMN; 0.4 and OTH: -1.6 & PLUSMN; 0.3 vs. O: -0.6 & PLUSMN; 0.3 bpm/mmHg) and tachycardic responses of baroreflex sensitivity (OT: -2.4 & PLUSMN; 0.8 and OTH: -2.4 & PLUSMN; 0.8 vs. O: -1.3 & PLUSMN; 0.5 bpm/mmHg), NADPH oxidase and IL-10/TNF-& alpha; ratio. Hexamethonium injection revealed reduced sympathetic contribution on basal AP in OTH group (OTH: -49.8 & PLUSMN; 12.4 vs. O: -74.6 & PLUSMN; 18.1 mmHg). Furthermore, cardiac sympathovagal balance (LF/HF ratio), IL-10 and antioxidant enzymes were enhanced in OTH group. AP variability and baroreflex sensitivity were correlated with systolic AP, RPP, LF/HF ratio and inflammatory and oxidative stress parameters. ConclusionThe combination of HCTZ plus concurrent exercise training induced additional positive adaptations in cardiovascular autonomic control, inflammation and redox balance in ovariectomized SHR. Therefore, combining exercise and medication may represent a promising strategy for managing classic and remaining cardiovascular risks in AH.
C1 [Ferreira, Maycon Junior; De Angelis, Katia] Univ Fed Sao Paulo UNIFESP, Exercise Physiol Lab, Sao Paulo, SP, Brazil.
   [Silva, Michel Pablo dos Santos Ferreira; De Angelis, Katia] Univ Nove Julho UNINOVE, Translat Physiol Lab, Sao Paulo, SP, Brazil.
   [Dias, Danielle da Silva; Irigoyen, Maria Claudia] Univ Sao Paulo, Heart Inst InCor, Sch Med, Hypertens Unit, Sao Paulo, SP, Brazil.
   [Dias, Danielle da Silva] Univ Fed Maranhao, Postgrad Program Phys Educ, Sao Luis, MA, Brazil.
   [Bernardes, Nathalia] Univ Sao Judas Tadeu USJT, Human Movement Lab, Sao Paulo, SP, Brazil.
C3 Universidade Federal de Sao Paulo (UNIFESP); Universidade Nove de Julho;
   Universidade de Sao Paulo; Universidade Federal do Maranhao;
   Universidade Sao Judas Tadeu
RP De Angelis, K (corresponding author), Univ Fed Sao Paulo UNIFESP, Exercise Physiol Lab, Sao Paulo, SP, Brazil.; De Angelis, K (corresponding author), Univ Nove Julho UNINOVE, Translat Physiol Lab, Sao Paulo, SP, Brazil.
EM prof.kangelis@yahoo.com.br
RI IRIGOYEN, MARIA/N-6880-2014; DE ANGELIS, KATIA/I-6098-2016; da Silva
   Dias, Danielle/AAN-7618-2020; Ferreira, Maycon/AET-1400-2022; Bernardes,
   Nathalia/L-7460-2015
OI Junior Ferreira, Maycon/0000-0001-7198-1908; Bernardes,
   Nathalia/0000-0001-9555-4134
FU Sao Paulo Research Foundation (FAPESP) [2019/06277-0]; National Council
   for Scientific and Technological Development (CNPq) [407398/2021-0,
   406792/2022-4]; CNPq Fellowship (CNPq-BPQ)
FX MJF: 2019/06277-0, Sao Paulo Research Foundation (FAPESP)
   (https://fapesp.br/). KDA and MCI: National Council for Scientific and
   Technological Development (CNPq) (407398/2021-0; 406792/2022-4)
   (https://www.gov.br/cnpq/pt-br). Katia De Angelis and Maria Claudia
   Irigoyen are recipients of CNPq Fellowship (CNPq-BPQ). The funders had
   no role in study design, data collection and analysis, decision to
   publish, or preparation of the manuscript.
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NR 67
TC 6
Z9 6
U1 0
U2 8
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD AUG 7
PY 2023
VL 18
IS 8
AR e0289715
DI 10.1371/journal.pone.0289715
PG 23
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA P6IY3
UT WOS:001051704700032
PM 37549182
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Hallajzadeh, J
   Milajerdi, A
   Mobini, M
   Amirani, E
   Azizi, S
   Nikkhah, E
   Bahadori, B
   Sheikhsoleimani, R
   Mirhashemi, SM
AF Hallajzadeh, Jamal
   Milajerdi, Alireza
   Mobini, Moein
   Amirani, Elaheh
   Azizi, Susan
   Nikkhah, Elhameh
   Bahadori, Babak
   Sheikhsoleimani, Razieh
   Mirhashemi, Seyyed Mehdi
TI Effects of Nigella sativa on glycemic control, lipid profiles,
   and biomarkers of inflammatory and oxidative stress: A systematic review
   and meta-analysis of randomized controlled clinical trials
SO PHYTOTHERAPY RESEARCH
LA English
DT Review
DE HDL-cholesterol; insulin resistance; LDL-cholesterol; meta-analysis;
   Nigella sativa; oxidative stress
ID TYPE-2 DIABETES-MELLITUS; CALORIE-RESTRICTED DIET; DOUBLE-BLIND; BLACK
   SEED; CYTOKINE RESPONSE; OBESE WOMEN; CARDIOVASCULAR-DISEASE; METABOLIC
   SYNDROME; BLOOD-GLUCOSE; OIL EXTRACT
AB The aim of this systematic review and meta-analysis was to evaluate the effects of Nigella sativa (N. sativa) on glycemic control, lipid profiles, and biomarkers of inflammatory and oxidative stress. Two independent authors systematically examined online databases consisting of, EMBASE, Scopus, PubMed, Cochrane Library, and Web of Science from inception until October 30, 2019. Cochrane Collaboration risk of bias tool was applied to assess the methodological quality of the studied trials. The heterogeneity among the included studies were assessed using the Cochrane's Q test and I-square (I-2) statistic. Data were pooled using a random-effects model and weighted mean difference (WMD) was considered as the overall effect size. A total of 50 trials were included in this meta-analysis. We found a significant reduction in total cholesterol (WMD: -16.80; 95% CI: -21.04, -12.55), triglycerides (WMD: -15.73; 95% CI: -20.77, -10.69), LDL-cholesterol (WMD: -18.45; 95% CI: -22.44, -14.94) and VLDL-cholesterol (WMD: -3.72; 95% CI: -7.27, -0.18) following supplementation with N. sativa. In addition, there was significant reductive effect observed with N. sativa on fasting glucose (WMD: -15.18; 95% CI: -19.82, -10.55) and HbA1C levels (WMD: -0.45; 95% CI: -0.66, -0.23). Effects of N. sativa on CRP (WMD: -3.61; 95% CI: -9.23, 2.01), TNF-alpha (WMD: -1.18; 95% CI: -3.23, 0.86), TAC (WMD: 0.31; 95% CI: 0.00, 0.63), and MDA levels (WMD: -0.95; 95% CI: -2.18, 0.27) were insignificant. This meta-analysis demonstrated the beneficial effects of N. sativa on fasting glucose, HbA1c, triglycerides, total-, VLDL-, LDL-cholesterol levels.
C1 [Hallajzadeh, Jamal] Maragheh Univ Med Sci, Res Ctr Evidence Based Hlth Management, Dept Biochem & Nutr, Maragheh, Iran.
   [Milajerdi, Alireza] Univ Tehran Med Sci, Students Sci Res Ctr, Tehran, Iran.
   [Milajerdi, Alireza] Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Community Nutr, Tehran, Iran.
   [Mobini, Moein] Univ Calgary, Fac Kinesiol, Calgary, AB, Canada.
   [Amirani, Elaheh] Kashan Univ Med Sci, Res Ctr Biochem & Nutr Metab Dis, Kashan, Iran.
   [Azizi, Susan] Maragheh Univ Med Sci, Student Res Committe, Maragheh, Iran.
   [Nikkhah, Elhameh; Bahadori, Babak] Maragheh Univ Med Sci, Med Plants Res Ctr, Maragheh, Iran.
   [Sheikhsoleimani, Razieh] Qazvin Univ Med Sci, Student Res Comm, Qazvin, Iran.
   [Mirhashemi, Seyyed Mehdi] Qazvin Univ Med Sci, Metab Dis Res Ctr, Res Inst Prevent Noncommunicable Dis, Qazvin, Iran.
C3 Tehran University of Medical Sciences; Tehran University of Medical
   Sciences; University of Calgary; Qazvin University of Medical Sciences
   (QUMS); Qazvin University of Medical Sciences (QUMS)
RP Mirhashemi, SM (corresponding author), Qazvin Univ Med Sci, Metab Dis Res Ctr, Res Inst Prevent Noncommunicable Dis, Qazvin, Iran.
EM jamal.hallaj@yahoo.com; amkhv@yahoo.com; mobinimoein@outlook.com;
   e.amirani74@gmail.com; azizi.susaan@gmail.com; tu8084@yahoo.com;
   mb.bahadori@gmail.com; razieh.sheikhsoleimani1@gmail.com;
   mirhashemismm@gmail.com
RI Mirhashemi, Seyyed/K-8628-2017; Milajerdi, Alireza/ABB-1854-2020;
   Bahadori, Mir Babak/P-8163-2016; hallajzadeh, jamal/W-2235-2017
OI Bahadori, Mir Babak/0000-0003-2556-4024; hallajzadeh,
   jamal/0000-0003-0696-9229
FU Qazvin University of Medical Sciences (QUMS) [IR.QUMS.REC.1398.307]
FX This study was supported by Qazvin University of Medical Sciences (QUMS)
   (No. IR.QUMS.REC.1398.307).
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NR 115
TC 24
Z9 24
U1 1
U2 9
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0951-418X
EI 1099-1573
J9 PHYTOTHER RES
JI Phytother. Res.
PD OCT
PY 2020
VL 34
IS 10
BP 2586
EP 2608
DI 10.1002/ptr.6708
EA MAY 2020
PG 23
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA OC4MU
UT WOS:000531491400001
PM 32394508
DA 2025-06-11
ER

PT J
AU Debeuf, T
   Verbeken, S
   Boelens, E
   Volkaert, B
   Van Malderen, E
   Michels, N
   Braet, C
AF Debeuf, Taaike
   Verbeken, Sandra
   Boelens, Elisa
   Volkaert, Brenda
   Van Malderen, Eva
   Michels, Nathalie
   Braet, Caroline
TI Emotion regulation training in the treatment of obesity in young
   adolescents: protocol for a randomized controlled trial
SO TRIALS
LA English
DT Article
DE Obesity; Emotion regulation training; Youngsters; Stress
ID BODY-MASS INDEX; CHILDHOOD OBESITY; WAIST CIRCUMFERENCE; REGULATION
   SKILLS; EATING STYLE; WEIGHT-GAIN; SELF-REPORT; INDIVIDUAL-DIFFERENCES;
   REGULATION STRATEGIES; METABOLIC SYNDROME
AB Background The prevalence rates of childhood obesity are increasing. The current multidisciplinary treatments for (childhood) obesity are effective but only moderately and in the short term. A possible explanation for the onset and maintenance of childhood obesity is that it reflects a maladaptive mechanism for regulating high levels of stress and emotions. Therefore, the current RCT study aims to test the effectiveness of adding an emotion regulation training to care as usual (multidisciplinary obesity treatment) in young inpatients (10-14) involved in an obesity treatment program compared to care as usual alone. The research model for this RCT study states that when high levels of stress are regulated in a maladaptive way, this can contribute to the development of obesity. Methods The current study will recruit 140 youngsters (10-14 years) who are involved in an inpatient multidisciplinary obesity treatment (MOT) program. After giving consent to participate in the study, youngsters will be randomly assigned, during consecutive waves, to one of two conditions: care as usual (receiving MOT) or intervention (receiving MOT in addition to emotion regulation training). The training itself consists of 12 weekly sessions, followed by a booster session after 3 and 5 months. The participants will be tested pretraining, post-training, and at 6 months' follow-up. We hypothesize that, compared to the control condition, youngsters in the intervention condition will (1) use more adaptive emotion regulation strategies and (2) report less emotional eating, both primary outcome measures. Moreover, on the level of secondary outcome measures, we hypothesize that youngsters in the intervention condition, compared with the control condition, will (3) report better sleep quality, (4) undergo improved weight loss and weight loss maintenance, and (5) experience better long-term (6-months) psychological well-being. Discussion This study will add to both the scientific and clinical literature on the role of emotion regulation in the development and maintenance of different psychopathologies, as emotion regulation is a transdiagnostic factor.
C1 [Debeuf, Taaike; Verbeken, Sandra; Boelens, Elisa; Volkaert, Brenda; Van Malderen, Eva; Michels, Nathalie; Braet, Caroline] Univ Ghent, Dept Dev Personal & Social Psychol, Ghent, Belgium.
C3 Ghent University
RP Debeuf, T (corresponding author), Univ Ghent, Dept Dev Personal & Social Psychol, Ghent, Belgium.
EM Taaike.Debeuf@Ugent.be
RI Michels, Nathalie/C-2819-2012
OI Van Malderen, Eva/0000-0002-4365-1888; Braet,
   Caroline/0000-0003-2458-287X; Michels, Nathalie/0000-0002-3069-7254
FU research foundation Bijzonder onderzoeksfonds (BOF) [BOF.24
   J.2016.0007.02]; fund IV1; BOF
FX The research foundation Bijzonder onderzoeksfonds (BOF) provides funding
   for this study under Grant Number BOF.24 J.2016.0007.02 with fund IV1.
   All the aspects of the protocol paper, design, and writing are funded by
   BOF.
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NR 154
TC 19
Z9 21
U1 2
U2 29
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1745-6215
J9 TRIALS
JI Trials
PD FEB 10
PY 2020
VL 21
IS 1
AR 153
DI 10.1186/s13063-019-4020-1
PG 17
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Research & Experimental Medicine
GA KW2PW
UT WOS:000521012100002
PM 32039739
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Bettermann, EL
   Hartman, TJ
   Easley, KA
   Ferranti, EP
   Jones, DP
   Quyyumi, AA
   Vaccarino, V
   Ziegler, TR
   Alvarez, JA
AF Bettermann, Erika L.
   Hartman, Terryl J.
   Easley, Kirk A.
   Ferranti, Erin P.
   Jones, Dean P.
   Quyyumi, Arshed A.
   Vaccarino, Viola
   Ziegler, Thomas R.
   Alvarez, Jessica A.
TI Higher Mediterranean Diet Quality Scores and Lower Body Mass Index Are
   Associated with a Less-Oxidized Plasma Glutathione and Cysteine Redox
   Status in Adults
SO JOURNAL OF NUTRITION
LA English
DT Article
DE diet; diet quality; glutathione; Mediterranean diet; oxidative stress;
   redox status
ID CARDIOVASCULAR RISK-FACTORS; CORONARY-HEART-DISEASE; OXIDATIVE STRESS;
   METABOLIC SYNDROME; INFLAMMATORY STRESS; GENERAL-POPULATION;
   PHYSICAL-ACTIVITY; PROBIOTIC YOGURT; CLINICAL-TRIAL; BLOOD-PRESSURE
AB Background: Both systemic redox status and diet quality are associated with risk outcomes in chronic disease. It is not known, however, the extent to which diet quality influences plasma thiol/disulfide redox status.
   Objective: The purpose of this study was to investigate the influence of diet, as measured by diet quality scores and other dietary factors, on systemic thiol/disulfide redox status.
   Methods: We performed a cross-sectional study of 685 working men and women (ages >= 18 y) in Atlanta, GA. Diet was assessed by 3 diet quality scores: the Alternative Healthy Eating Index (AHEI), Dietary Approaches to Stop Hypertension (DASH), and the Mediterranean Diet Score (MDS). We measured concentrations of plasma glutathione (GSH), cysteine, their associated oxidized forms [glutathione disulfide (GSSG) and cystine (CySS), respectively], and their redox potentials (E(h)GSSG and EhCySS) to determine thiol/disulfide redox status. Linear regression modeling was performed to assess relations between diet and plasma redox after adjustment for age, body mass index (BMI), sex, race, and history of chronic disease.
   Results: MDS was positively associated with plasma GSH (beta = 0.02; 95% CI: 0.003, 0.03) and total GSH (GSH + GSSG) (beta = 0.02; 95% CI: 0.003, 0.03), and inversely associated with the CySS: GSH ratio (beta = -0.02; 95% CI: -0.04, -0.004). There were significant independent associations between individual MDS components (dairy, vegetables, fish, and monounsaturated fat intake) and varying plasma redox indexes (P < 0.05). AHEI and DASH diet quality indexes and other diet factors of interest were not significantly correlated with plasma thiol and disulfide redox measures.
   Conclusion: Adherence to the Mediterranean diet was significantly associated with a favorable plasma thiol/disulfide redox profile, independent of BMI, in a generally healthy working adult population. Although longitudinal studies are warranted, these findings contribute to the feasibility of targeting a Mediterranean diet to improve plasma redox status.
C1 [Bettermann, Erika L.; Hartman, Terryl J.; Vaccarino, Viola] Emory Univ, Rollins Sch Publ Hlth, Dept Epidemiol, Atlanta, GA 30322 USA.
   [Easley, Kirk A.] Emory Univ, Rollins Sch Publ Hlth, Dept Biostat & Bioinformat, Atlanta, GA 30322 USA.
   [Ferranti, Erin P.] Emory Univ, Nell Hodgson Woodruff Sch Nursing, Atlanta, GA 30322 USA.
   [Jones, Dean P.] Emory Univ, Sch Med, Div Pulm Allergy Crit Care & Sleep Med, Atlanta, GA USA.
   [Jones, Dean P.; Ziegler, Thomas R.; Alvarez, Jessica A.] Emory Univ, Sch Med, Ctr Clin & Mol Nutr, Atlanta, GA 30322 USA.
   [Quyyumi, Arshed A.] Emory Univ, Sch Med, Div Cardiol, Atlanta, GA 30322 USA.
   [Ziegler, Thomas R.; Alvarez, Jessica A.] Emory Univ, Sch Med, Dept Med, Div Endocrinol Metab & Lipids, Atlanta, GA 30322 USA.
   [Ziegler, Thomas R.] Atlanta Vet Affairs Med Ctr, Sect Endocrinol, Atlanta, GA USA.
C3 Emory University; Rollins School Public Health; Emory University;
   Rollins School Public Health; Emory University; Emory University; Emory
   University; Emory University; Emory University; US Department of
   Veterans Affairs; Veterans Health Administration (VHA); Atlanta VA
   Health Care System
RP Alvarez, JA (corresponding author), Emory Univ, Sch Med, Ctr Clin & Mol Nutr, Atlanta, GA 30322 USA.; Alvarez, JA (corresponding author), Emory Univ, Sch Med, Dept Med, Div Endocrinol Metab & Lipids, Atlanta, GA 30322 USA.
EM jessica.alvarez@emory.edu
RI Vaccarino, Viola/AAW-5600-2020; Easley, Kirk/K-6910-2015
OI Vaccarino, Laura Viola/0000-0002-9054-0654; Easley,
   Kirk/0000-0003-4419-2617
FU Emory University Rollins School of Public Health; National Institutes of
   Health [UL1 TR000454, K01 DK102851, K24 DK096574, P30 ES019776]
FX Supported by the Emory University Rollins School of Public Health and
   grants from the National Institutes of Health: UL1 TR000454 (Atlanta
   Clinical and Translational Science Institute), K01 DK102851 (JAA), K24
   DK096574 (TRZ), and P30 ES019776 (Health and Exposome Research Center at
   Emory; ELB, DPJ, TRZ, JAA).
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NR 61
TC 32
Z9 34
U1 0
U2 10
PU AMER SOC NUTRITION-ASN
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-3166
EI 1541-6100
J9 J NUTR
JI J. Nutr.
PD FEB
PY 2018
VL 148
IS 2
BP 245
EP 253
DI 10.1093/jn/nxx045
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA FY4YF
UT WOS:000426832500012
PM 29490099
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Ndisang, JF
   Lane, N
   Syed, N
   Jadhav, A
AF Ndisang, Joseph Fomusi
   Lane, Nina
   Syed, Noor
   Jadhav, Ashok
TI Up-Regulating the Heme Oxygenase System with Hemin Improves Insulin
   Sensitivity and Glucose Metabolism in Adult Spontaneously Hypertensive
   Rats
SO ENDOCRINOLOGY
LA English
DT Article
ID NF-KAPPA-B; ACTIVATED SIGNALING PATHWAYS; INCREASES ADIPONECTIN LEVELS;
   BETA-CELL DYSFUNCTION; OXIDATIVE STRESS; ENDOTHELIAL DYSFUNCTION;
   NITRIC-OXIDE; CARBON-MONOXIDE; 3T3-L1 ADIPOCYTES; TERMINAL KINASE
AB Accumulating clinical evidence indicates that impaired glucose tolerance is a common phenomenon in essential hypertension. Although recent evidence underscores the role of heme-oxygenase (HO) in diabetes, its effects on insulin sensitivity and glucose metabolism in spontaneously hypertensive rat (SHR), a model of essential hypertension with characteristics of metabolic syndrome including insulin resistance/impaired glucose metabolism remains largely unclear. Here we report the effects of the HO inducer, hemin, and the HO blocker, chromium-mesoporphyrin on insulin sensitivity and glucose metabolism in SHRs. Adult SHRs were severely hypertensive but normoglycemic. Hemin therapy lowered blood pressure, increased plasma insulin, decreased glycemia, and enhanced insulin sensitivity by improving glucose tolerance (ip glucose tolerance test) and insulin tolerance (ip insulin tolerance test) but reduced insulin resistance (homeostasis model assessment index). These effects were accompanied by increased gastrocnemius muscle HO-1, HO activity, cGMP, cAMP alongside antioxidants including bilirubin, ferritin, superoxide dismutase, catalase, and the total antioxidant capacity, whereas oxidative/inflammatory mediators like 8-isoprostance, nuclear-factor-kappa B, activating-protein-1, activating-protein-2, c-Jun-NH2-terminal-kinase, and heme were abated. Furthermore, hemin reduced proteinuria/albuminuria and enhanced the depressed levels of adiponectin, AMP-activated protein-kinase, and glucose transporter-4 in SHRs, suggesting that although SHRs are normoglycemic, insulin signaling and renal function may be impaired. Contrarily, the HO inhibitor chromium-mesoporphyrin exacerbated oxidative stress, aggravated insulin resistance, glucose tolerance, insulin tolerance and nephropathy. Hemin also enhanced HO signaling in Wistar Kyoto and Sprague Dawley rats and increased insulin sensitivity albeit less intensely than in SHRs, suggesting greater selectivity of HO in SHRs with dysfunctional insulin signaling. These results suggest that perturbations of insulin signaling may be a forerunner to hyperglycemia in essential hypertension. By concomitantly potentiating insulin-sensitizing agents, suppressing insulin/glucose intolerance, and abating oxidative stress, HO inducers may prevent metabolic and cardiovascular complications in essential hypertension. (Endocrinology 151: 549-560, 2010)
C1 [Ndisang, Joseph Fomusi; Lane, Nina; Jadhav, Ashok] Univ Saskatchewan, Dept Physiol, Coll Med, Saskatoon, SK S7N 5E5, Canada.
   [Syed, Noor] Univ Saskatchewan, Dept Microbiol, Coll Med, Saskatoon, SK S7N 5E5, Canada.
C3 University of Saskatchewan; University of Saskatchewan
RP Ndisang, JF (corresponding author), Univ Saskatchewan, Dept Physiol, Coll Med, 107 Wiggins Rd, Saskatoon, SK S7N 5E5, Canada.
EM joseph.ndisang@usask.ca
FU Heart and Stroke Foundation of Saskatchewan, Canada; Canadian Institutes
   for Health Research/University of Saskatchewan Bridge
FX We thank James Talbot, Department of Physiology, College of Medicine,
   University of Saskatchewan, for technical assistance.Address all
   correspondence and requests for reprints to: Dr. Joseph Fomusi Ndisang,
   Department of Physiology, College of Medicine, University of
   Saskatchewan, 107 Wiggins Road, Saskatoon, Saskatchewan, Canada S7N 5E5.
   E-mail: joseph.ndisang@usask.ca.This work was supported by the Heart and
   Stroke Foundation of Saskatchewan, Canada, and Canadian Institutes for
   Health Research/University of Saskatchewan Bridge funding.Disclosure
   Summary: The authors have nothing to disclose.
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NR 65
TC 83
Z9 85
U1 1
U2 6
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0013-7227
EI 1945-7170
J9 ENDOCRINOLOGY
JI Endocrinology
PD FEB
PY 2010
VL 151
IS 2
BP 549
EP 560
DI 10.1210/en.2009-0471
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 548GR
UT WOS:000273948600014
PM 20016031
OA Bronze
DA 2025-06-11
ER

PT J
AU Panduru, NM
   Ion, DA
   Mota, M
   Cimponeriu, D
   Stavarachi, M
   Pisoschi, C
   Radu, S
   Anghel, M
   Mota, E
AF Panduru, Nicolae Mircea
   Ion, Daniela Adriana
   Mota, Maria
   Cimponeriu, Dan
   Stavarachi, Monica
   Pisoschi, Catalina
   Radu, Stefania
   Anghel, Monica
   Mota, Eugen
TI GLUTATHIONE PEROXIDASE 1 (GPX-1) PRO200LEU POLYMORPHISM AND DIABETIC
   NEPHROPATHY IN TYPE 1 DIABETES - A PRELIMINARY STUDY
SO ROMANIAN BIOTECHNOLOGICAL LETTERS
LA English
DT Article
DE diabetic nephropathy; type 1 diabetes; risk factor; glutathione
   peroxidase 1 (GPX-1); Pro198Leu; polymorphism; oxidative stress;
   antioxidant enzymes
ID NITRIC-OXIDE SYNTHASE; INSULIN-RESISTANCE; OXIDATIVE STRESS;
   ANGIOTENSIN-II; METABOLIC SYNDROME; HYDROGEN-PEROXIDE; ENDOTHELIAL
   DYSFUNCTION; SUPEROXIDE-DISMUTASE; UP-REGULATION; PITTSBURGH
   EPIDEMIOLOGY
AB Superoxide (ROS) production induced by hyperglycaemia seems to be the key-event in pathogenic pathways activation in diabetic nephropathy (DN). Glutathione peroxidase 1 (GPX-1) is a key-enzyme implied in defense against oxidative stress. The purpose of this study was to assess the association of Pro200Leu (known also as Pro198Leu) polymorphism in GPX-1 gene with risk to develop DN, in type 1 diabetes (T1D). We studied 238 patients with T1D, divided in group A (106 patients) with macroalbuminuria or ESRD (End Stage Renal Disease) and group B (132 patients) without microalbuminuria. Genotyping was performed using PCR-RFLP. Hardy-Weinberg equilibrium was observed in group B (p=0.564), in group A being a deviation which had not reached statistical significance (p=0.089). At the association test. ProPro[OR=2.614. 95%C.1.(1.163-5.872), p=0.017] was the risk genotype and LeuLeu genotype was protective [OR=0.383. 95%C.I.(0.170-0.860), p=0.017] for overt DN. The distribution of alleles in the two groups was significantly different. These differences were concordant with data from the association test, both for Pro allele [ORpro = 1.590, 95%C.I.(1.082-2.335). p=0.017] and for Leu allele [ORleu = 0.629. 95%CI (0.428-0.924), p=0.017]. Pro allele of Pro200Leu polymorphism was associated with the high risk for advanced DN in patients with type Idiabetes in Romania. The results are hard to be interpreted, as this is the first report of this polymorphism in DN, and the frequencies of alleles differ from those in the literature. Further studies are necessary in order to replicate this association, and to explain the intervention mechanism of this polymorphism in DN.
C1 [Panduru, Nicolae Mircea] NC Paulescu Natl Inst Diabet Nutr & Metab Dis, Diabet Clin 2, Bucharest 020475, Romania.
   [Panduru, Nicolae Mircea; Ion, Daniela Adriana] Carol Davila Univ Med & Pharm Bucharest, Bucharest, Romania.
   [Cimponeriu, Dan; Stavarachi, Monica] Univ Bucharest, Genet Inst, Bucharest, Romania.
   [Mota, Maria; Pisoschi, Catalina; Mota, Eugen] Craiova Univ Med & Pharm, Craiova, Romania.
C3 Carol Davila University of Medicine & Pharmacy; University of Bucharest;
   University of Medicine & Pharmacy of Craiova
RP Panduru, NM (corresponding author), NC Paulescu Natl Inst Diabet Nutr & Metab Dis, Diabet Clin 2, 5-7 Ion Movila St, Bucharest 020475, Romania.
EM nicoly_pinn@yahoo.com
RI panduru, nicolae/AAB-9885-2021; Pisoschi, Catalina/G-4321-2019;
   Cimponeriu, Danut/AAT-4687-2021
FU  [CNCSIS-PNCDI-II-RU-ID-1194/2009];  [POSDRU/89/1.5/S/64109]
FX This study was partially supported by CNCSIS-PNCDI-II-RU-ID-1194/2009
   and POSDRU/89/1.5/S/64109.
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NR 101
TC 2
Z9 3
U1 0
U2 8
PU ARS DOCENDI
PI BUCHAREST
PA SOS PANDURI 90, SECT 5, BUCHAREST, RO-050663, ROMANIA
SN 1224-5984
J9 ROM BIOTECH LETT
JI Rom. Biotech. Lett.
PD SEP-OCT
PY 2011
VL 16
IS 5
BP 6655
EP 6667
PG 13
WC Biotechnology & Applied Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology
GA 841CA
UT WOS:000296488700023
DA 2025-06-11
ER

PT J
AU Monserrat-Mesquida, M
   Quetglas-Llabrés, M
   Bouzas, C
   Montemayor, S
   Mascaró, CM
   Casares, M
   Llompart, I
   Ugarriza, L
   Martínez, JA
   Tur, JA
   Sureda, A
AF Monserrat-Mesquida, Margalida
   Quetglas-Llabres, Magdalena
   Bouzas, Cristina
   Montemayor, Sofia
   Mascaro, Catalina M.
   Casares, Miguel
   Llompart, Isabel
   Ugarriza, Lucia
   Martinez, J. Alfredo
   Tur, Josep A.
   Sureda, Antoni
TI Increased Adherence to the Mediterranean Diet after Lifestyle
   Intervention Improves Oxidative and Inflammatory Status in Patients with
   Non-Alcoholic Fatty Liver Disease
SO ANTIOXIDANTS
LA English
DT Article
DE Mediterranean diet; fatty liver; aerobic capacity; oxidative stress;
   inflammation
ID VIRGIN OLIVE OIL; METABOLIC SYNDROME; PHYSICAL-ACTIVITY; FOLLOW-UP;
   STRESS; ANTIOXIDANT; MYELOPEROXIDASE; SEVERITY; VALIDITY; OBESITY
AB Background: A Mediterranean diet (MedDiet) is recommended as a therapy for non-alcoholic fatty liver disease (NAFLD) because there is no specific pharmacological treatment for this disease. Objective: To assess the relationship between the adherence to the Mediterranean diet and the intrahepatic fat content (IFC), levels of oxidative stress, and inflammation biomarkers after a 6-month lifestyle intervention in NAFLD patients. Methods: Patients diagnosed with NAFLD (n = 60 adults; 40-60 years old) living in the Balearic Islands, Spain, were classified into two groups, according to the adherence to the MedDiet after 6 months of lifestyle intervention. Anthropometry, blood pressure, IFC, maximal oxygen uptake, and pro/antioxidant and inflammatory biomarkers were measured in plasma and in PBMCs before and after the intervention. Results: Reductions in weight, body mass index, IFC, blood pressure levels, circulating glucose, glycosylated hemoglobin, and markers of liver damage-aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma-glutamyl transferase (GGT), and cytokeratin 18 (CK-18)-were observed after the intervention. The highest reductions were observed in the group with the best adherence to the MedDiet. A significant improvement in cardiorespiratory fitness was also observed in the group with a higher adherence. The activities of catalase in plasma and catalase and superoxide dismutase in blood mononuclear cells increased only in the group with a higher adherence, as well as the catalase gene expression in the blood mononuclear cells. The plasma levels of malondialdehyde and myeloperoxidase decreased, and resolvin-D1 increased in both groups after the intervention, whereas interleukin-6 levels decreased only in the group with a higher adherence to the MedDiet. Conclusions: A greater adherence to the MedDiet is related to greater improvements in IFC, cardiorespiratory fitness, and pro-oxidative and proinflammatory status in NAFLD patients after a 6-month nutritional intervention based on the MedDiet.
C1 [Monserrat-Mesquida, Margalida; Quetglas-Llabres, Magdalena; Bouzas, Cristina; Montemayor, Sofia; Mascaro, Catalina M.; Llompart, Isabel; Ugarriza, Lucia; Tur, Josep A.; Sureda, Antoni] Univ Balearic Isl IUNICS, Res Grp Community Nutr & Oxidat Stress, Palma De Mallorca 07122, Spain.
   [Monserrat-Mesquida, Margalida; Quetglas-Llabres, Magdalena; Bouzas, Cristina; Llompart, Isabel; Ugarriza, Lucia; Tur, Josep A.; Sureda, Antoni] Hlth Res Inst Balearic Isl IdISBa, Palma De Mallorca 07120, Spain.
   [Monserrat-Mesquida, Margalida; Bouzas, Cristina; Montemayor, Sofia; Mascaro, Catalina M.; Llompart, Isabel; Tur, Josep A.; Sureda, Antoni] Inst Salud Carlos III ISCIII, CIBER Fisiopatol Obesidad & Nutr CIBEROBN, Madrid 28029, Spain.
   [Casares, Miguel] Red Asistencial Juaneda, Radiodiag Serv, Palma De Mallorca 07011, Spain.
   [Llompart, Isabel] Univ Hosp Son Espases, Clin Anal Serv, Palma De Mallorca 07198, Spain.
   [Ugarriza, Lucia] Camp Redo Primary Hlth Care Ctr, Palma De Mallorca 07010, Spain.
   [Martinez, J. Alfredo] CEI UAM CSIC, IMDEA Food, Cardiomet Precis Nutr Program, Madrid 28049, Spain.
   [Martinez, J. Alfredo] Univ Navarra, Dept Nutr Food Sci & Physiol, Pamplona 31008, Spain.
C3 Institut Investigacio Sanitaria Illes Balears (IdISBa); CIBER - Centro
   de Investigacion Biomedica en Red; CIBEROBN; Hospital Universitari Son
   Espases; Consejo Superior de Investigaciones Cientificas (CSIC); IMDEA
   Food Institute; University of Navarra
RP Tur, JA (corresponding author), Univ Balearic Isl IUNICS, Res Grp Community Nutr & Oxidat Stress, Palma De Mallorca 07122, Spain.; Tur, JA (corresponding author), Hlth Res Inst Balearic Isl IdISBa, Palma De Mallorca 07120, Spain.; Tur, JA (corresponding author), Inst Salud Carlos III ISCIII, CIBER Fisiopatol Obesidad & Nutr CIBEROBN, Madrid 28029, Spain.
EM margalida.monserrat@uib.es; m.quetglas@uib.es; cristina.bouzas@uib.es;
   sofiamf16@gmail.com; c.mascaro@uib.es; casaresmiguel@gmail.com;
   isabel.llompart@ssib.es; luciaugarriza@gmail.com;
   jalfredo.martinez@imdea.org; pep.tur@uib.es; antoni.sureda@uib.es
RI Bouzas, Cristina/AAE-2069-2019; Tur, Josep/AAE-5748-2020; Sureda,
   Antoni/N-9588-2019; Quetglas Llabrés, Maria/AAA-4412-2019; Martinez,
   Juan/GXM-4393-2022; Mesquida, Margalida/AAB-4773-2019; Tur,
   Josep/F-5576-2014
OI Bouzas Velasco, Cristina/0000-0002-1407-8461; Monserrat Mesquida,
   Margalida/0000-0002-8856-135X; Montemayor, Sofia/0000-0001-7833-2118; ,
   Antoni/0000-0001-8656-6838; Tur, Josep/0000-0002-6940-0761
FU Fundacio La Marato TV3 (Spain) project [201630.10]; Instituto de Salud
   Carlos III through the Fondo de Investigacion para la Salud - European
   Regional Development Fund [CIBEROBN CB12/03/30038]; IDISBA Grant
   (FOLIUM); IDISBA Grant (PRIMUS); IDISBA Grant (SYNERGIA); IDISBA Grant
   (LIBERI); IDISBA grant; FPU PhD grant from the Spanish Ministry of
   Education; IDISBA pre-doctoral grant
FX Fundacio La Marato TV3 (Spain) project ref. 201630.10. Instituto de
   Salud Carlos III through the Fondo de Investigacion para la Salud
   (CIBEROBN CB12/03/30038), which are cofunded by the European Regional
   Development Fund. IDISBA Grants (FOLIUM, PRIMUS, SYNERGIA, and LIBERI).
   M.Q.-LL. was granted by the IDISBA grant. C.M.M. received an FPU PhD
   grant from the Spanish Ministry of Education. M.Q.-LL. was granted by
   the IDISBA pre-doctoral grant. The funding sponsors had no role in the
   design of the study; in the collection, analyses, or interpretation of
   the data; in the writing of the manuscript; or in the decision to
   publish the results.
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NR 70
TC 14
Z9 14
U1 0
U2 6
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD AUG
PY 2022
VL 11
IS 8
AR 1440
DI 10.3390/antiox11081440
PG 16
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA 4C4CP
UT WOS:000846404000001
PM 35892642
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Sukumaran, V
   Tsuchimochi, H
   Sonobe, T
   Waddingham, MT
   Shirai, M
   Pearson, JT
AF Sukumaran, Vijayakumar
   Tsuchimochi, Hirotsugu
   Sonobe, Takashi
   Waddingham, Mark T.
   Shirai, Mikiyasu
   Pearson, James T.
TI Liraglutide treatment improves the coronary microcirculation in insulin
   resistant Zucker obese rats on a high salt diet
SO CARDIOVASCULAR DIABETOLOGY
LA English
DT Article
DE Endothelial dysfunction; Inflammation; Liraglutide; Nitric oxide;
   Oxidative stress
ID PEPTIDE-1 ANALOG LIRAGLUTIDE; OXIDATIVE STRESS; NITRIC-OXIDE; GLP-1
   ANALOG; ENDOTHELIAL DYSFUNCTION; DB/DB MICE; RECEPTOR; EXPRESSION;
   HYPERTENSION; VASODILATION
AB Background Obesity, hypertension and prediabetes contribute greatly to coronary artery disease, heart failure and vascular events, and are the leading cause of mortality and morbidity in developed societies. Salt sensitivity exacerbates endothelial dysfunction. Herein, we investigated the effect of chronic glucagon like peptide-1 (GLP-1) receptor activation on the coronary microcirculation and cardiac remodeling in Zucker rats on a high-salt diet (6% NaCl). Methods Eight-week old Zucker lean (+/+) and obese (fa/fa) rats were treated with vehicle or liraglutide (LIRA) (0.1 mg/kg/day, s.c.) for 8 weeks. Systolic blood pressure (SBP) was measured using tail-cuff method in conscious rats. Myocardial function was assessed by echocardiography. Synchrotron contrast microangiography was then used to investigate coronary arterial vessel function (vessels 50-350 mu m internal diameter) in vivo in anesthetized rats. Myocardial gene and protein expression levels of vasoactive factors, inflammatory, oxidative stress and remodeling markers were determined by real-time PCR and Western blotting. Results We found that in comparison to the vehicle-treated fa/fa rats, rats treated with LIRA showed significant improvement in acetylcholine-mediated vasodilation in the small arteries and arterioles (< 150 mu m diameter). Neither soluble guanylyl cyclase or endothelial NO synthase (eNOS) mRNA levels or total eNOS protein expression in the myocardium were significantly altered by LIRA. However, LIRA downregulated Nox-1 mRNA (p = 0.030) and reduced ET-1 protein (p = 0.044) expression. LIRA significantly attenuated the expressions of proinflammatory and profibrotic associated biomarkers (NF-kappa B, CD68, IL-1 beta, TGF-beta 1, osteopontin) and nitrotyrosine in comparison to fa/fa-Veh rats, but did not attenuate perivascular fibrosis appreciably. Conclusions In a rat model of metabolic syndrome, chronic LIRA treatment improved the capacity for NO-mediated dilation throughout the coronary macro and microcirculations and partially normalized myocardial remodeling independent of changes in body mass or blood glucose.
C1 [Sukumaran, Vijayakumar] Qatar Univ, Dept Basic Med Sci, Coll Med, Doha, Qatar.
   [Sukumaran, Vijayakumar] Qatar Univ, QU Hlth, Doha, Qatar.
   [Sukumaran, Vijayakumar; Tsuchimochi, Hirotsugu; Sonobe, Takashi; Waddingham, Mark T.; Shirai, Mikiyasu; Pearson, James T.] Natl Cerebral & Cardiovasc Ctr, Dept Cardiac Physiol, Res Inst, Suita, Osaka 5648565, Japan.
   [Pearson, James T.] Monash Univ, Monash Biomed Discovery Inst, Dept Physiol, Clayton, Vic 3800, Australia.
   [Sukumaran, Vijayakumar] Qatar Univ, Dept Pharmacol, Coll Med, Doha, Qatar.
   [Waddingham, Mark T.] Natl Cerebral & Cardiovasc Ctr, Dept Adv Med Res Pulm Hypertens, Res Inst, Suita, Osaka 5648565, Japan.
C3 Qatar University; Qatar University; National Cerebral & Cardiovascular
   Center - Japan; Monash University; Qatar University; National Cerebral &
   Cardiovascular Center - Japan
RP Sukumaran, V (corresponding author), Qatar Univ, QU Hlth, Doha, Qatar.; Sukumaran, V (corresponding author), Qatar Univ, Dept Pharmacol, Coll Med, Doha, Qatar.
EM Vijay@qu.edu.qa
RI Tsuchimochi, Hirotsugu/D-8224-2011; Sukumaran, Vijayakumar/K-8523-2015;
   Sonobe, Takashi/Q-6600-2016; Pearson, James/B-4631-2012
OI Waddingham, Mark/0000-0002-0058-9455; VIJAYAKUMAR,
   SUKUMARAN/0000-0002-2686-7329; Pearson, James/0000-0002-3318-5406
FU Novo Nordisk Pharma Ltd.
FX Professor James T. Pearson and Dr. VijayaKumar Sukumaran recipients of
   investigator-initiated industry funding for distinct research projects
   from Novo Nordisk Pharma Ltd., an affiliate of Novo Nordisk A/S of
   Denmark.
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NR 49
TC 34
Z9 37
U1 2
U2 11
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1475-2840
J9 CARDIOVASC DIABETOL
JI Cardiovasc. Diabetol.
PD FEB 24
PY 2020
VL 19
IS 1
AR 24
DI 10.1186/s12933-020-01000-z
PG 16
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism
GA KV4NS
UT WOS:000520459500001
PM 32093680
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Li, D
   Song, LL
   Wang, J
   Meng, C
   Cui, XG
AF Li, Di
   Song, Lin-Lin
   Wang, Juan
   Meng, Chao
   Cui, Xiao-Guang
TI Adiponectin protects against lung ischemia-reperfusion injury in rats
   with type 2 diabetes mellitus
SO MOLECULAR MEDICINE REPORTS
LA English
DT Article
DE adiponectin; diabetes mellitus; lung ischemia-reperfusion injury;
   5'adenosine monophosphate-activated protein kinase
ID CORONARY-ARTERY-DISEASE; FATTY-ACID OXIDATION; INSULIN-RESISTANCE;
   STIMULATES ANGIOGENESIS; HORMONE ADIPONECTIN; METABOLIC SYNDROME;
   ENDOTHELIAL-CELLS; KINASE; ACTIVATION; AMPK
AB Adiponectin (APN) has been associated with the pathogenesis of acute brain, liver and heart injury. However, the role of APN in lung ischemia-reperfusion injury (LIRI) in diabetes mellitus remains unclear. To investigate this, the present study evaluated the effects of APN on lung dysfunction and pathological alterations in rats with type 2 diabetes mellitus via lung ischemia/reperfusion (I/R). The lung-protective effects of APN globular domain (gAPN) in rats with type 2 diabetes mellitus were also investigated by measuring the oxygenation index, inflammatory cytokines, lung edema, histopathology, oxidative stress, apoptosis and the protein expression levels of phosphorylated 5adenosine monophosphate-activated protein kinase (p-AMPK), endothelial nitric oxide synthase (eNOS) and inducible nitric oxide synthase (iNOS). The results of the present study demonstrated that the diabetes mellitus rats + I/R (DIR) group exhibited greater concentrations of tumor necrosis factor- and interleukin-6, and increases in the wet-weight to dry-weight ratio, lung injury score, oxidative stress and cellular apoptosis. These effects were accompanied by lower pulmonary oxygenation compared with the normal rat + I/R (NIR) group (P<0.05). Additionally, all of these alterations were attenuated in the NIR + gAPN and DIR + gAPN groups compared with in the NIR and DIR groups, respectively. In the DIR group, the expression levels of p-AMPK/AMPK and eNOS were significantly downregulated, and the levels of iNOS were upregulated, compared with those of the NIR group. Treatment with APN activated AMPK, increased eNOS expression and attenuated iNOS expression. The results of the present study demonstrated that APN exerted protective effects against LIRI via its anti-inflammatory, antioxidative stress and anti-apoptotic activities. These protective effects of APN were eliminated in rats with type 2 diabetes mellitus, in which LIRI was exacerbated. The present study indicated that APN may be a potential therapeutic agent for LIRI in type 2 diabetes mellitus.
C1 [Li, Di; Song, Lin-Lin; Wang, Juan; Meng, Chao; Cui, Xiao-Guang] Harbin Med Univ, Affiliated Hosp 2, Heilongjiang Prov Key Lab Res Anesthesiol & Crit, Dept Anesthesiol, 194 Xuefu Rd, Harbin 150001, Heilongjiang, Peoples R China.
C3 Harbin Medical University
RP Cui, XG (corresponding author), Harbin Med Univ, Affiliated Hosp 2, Heilongjiang Prov Key Lab Res Anesthesiol & Crit, Dept Anesthesiol, 194 Xuefu Rd, Harbin 150001, Heilongjiang, Peoples R China.
EM cuixiaoguang1018@126.com
RI Li, Di/HZI-7636-2023
OI Meng, Chao/0000-0001-6720-1307
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NR 48
TC 20
Z9 22
U1 1
U2 12
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1791-2997
EI 1791-3004
J9 MOL MED REP
JI Mol. Med. Rep.
PD MAY
PY 2018
VL 17
IS 5
BP 7191
EP 7201
DI 10.3892/mmr.2018.8748
PG 11
WC Oncology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Research & Experimental Medicine
GA GD5OR
UT WOS:000430556800123
PM 29568898
OA Green Published, Green Submitted, hybrid
DA 2025-06-11
ER

PT J
AU Andersen, CJ
   Walker, BG
   Karanian, TJ
   Sloan, A
   Campbell, C
   Dupree, L
   Woodruff, R
AF Andersen, Catherine J.
   Walker, Brian G.
   Karanian, Thomas J.
   Sloan, Allison
   Campbell, Courtney
   Dupree, Lydia
   Woodruff, Rachael
TI Diurnal patterns of salivary cytokines differentially correlate with
   greater fluctuations in cortisol and diet composition: A pilot study
SO JOURNAL OF AGRICULTURE AND FOOD RESEARCH
LA English
DT Article
DE Salivary cortisol; Cortisol fluctuations; Lifestyle factors; Dietary
   patterns; Salivary cytokines; Metabolic profiles
ID RISK-FACTORS; METABOLIC SYNDROME; CARBOHYDRATE RESTRICTION; INFLAMMATORY
   CYTOKINES; CARDIOVASCULAR-DISEASE; PLASMA-CORTISOL; SEX-DIFFERENCES;
   STRESS; OBESITY; POLICE
AB Chronic stress and elevated cortisol are associated with adverse metabolic profiles and lifestyle patterns, systemic low-grade inflammation, and increased chronic disease risk; however, it is less clear how the degree of cortisol fluctuations impacts these parameters. Adult men and women (18-70y) were recruited to participate in a 5-day observational study, in which they underwent a baseline health and body composition assessment, completed 5day diet, exercise, and stress records, and provided saliva samples in the morning, afternoon, and evening to measure fluctuations in cortisol, interleukin-1 beta (IL-1 beta), and IL -6. Degree of cortisol variability over the 5-day period (highest cortisol measure - lowest cortisol measure) was used to classify subjects into high (n = 9) and low (n = 9) cortisol fluctuation groups. Participants with greater fluctuations in salivary cortisol had higher salivary cortisol concentrations on average, which was attributed to higher maximal and morning cortisol. A greater proportion of individuals with higher cortisol flux worked in first responder/emergency professions, and exhibited minimal dietary pattern differences compared to those with low cortisol flux. While body fat percentage and mass positively correlated with minimum salivary cortisol measures, body composition and blood pressure did not differ between low vs. high salivary cortisol flux groups. Interestingly, we observed diurnal patterns of salivary IL-1 beta concentrations, with higher IL-1 beta in the morning, and greater afternoon IL-1 beta in the high cortisol flux group compared to the low cortisol flux group. Independent of cortisol flux, waking satiety and intake patterns of dietary nutrients and food groups/type differentially correlated with salivary cytokine concentrations in a time of day-dependent manner. Our findings suggest that greater fluctuations in cortisol are associated with distinct diurnal salivary cortisol and IL-1 beta concentrations but minimal lifestyle and dietary factors, whereas dietary patterns are strongly and differentially associated with salivary cytokine profiles.
C1 [Andersen, Catherine J.; Walker, Brian G.; Karanian, Thomas J.; Sloan, Allison; Campbell, Courtney; Dupree, Lydia] Fairfield Univ, Dept Biol, Fairfield, CT USA.
   [Andersen, Catherine J.; Woodruff, Rachael] Univ Connecticut, Dept Nutr Sci, 27 Manter Rd, Storrs, CT 06269 USA.
C3 Fairfield University; University of Connecticut
RP Andersen, CJ (corresponding author), Univ Connecticut, Dept Nutr Sci, 27 Manter Rd, Storrs, CT 06269 USA.
EM catherine.andersen@uconn.edu
OI Andersen, Catherine/0000-0001-9774-5030; Walker,
   Brian/0000-0001-7345-2110
FU Fairfield University College of Arts Sciences
FX <BOLD>Funding</BOLD> This research was funded by the Fairfield
   University College of Arts & Sciences to CJA. The funders had no role in
   study design, data collection and analysis, decision to publish, or
   preparation of the manuscript.
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NR 79
TC 2
Z9 2
U1 2
U2 6
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2666-1543
J9 J AGR FOOD RES
JI J. Agric. Food Res.
PD SEP
PY 2024
VL 17
AR 101231
DI 10.1016/j.jafr.2024.101231
EA JUN 2024
PG 12
WC Agriculture, Multidisciplinary; Food Science & Technology
WE Emerging Sources Citation Index (ESCI)
SC Agriculture; Food Science & Technology
GA US9U7
UT WOS:001250173100001
OA gold
DA 2025-06-11
ER

PT J
AU Fontes, A
   Alemany-Pagès, M
   Oliveira, PJ
   Ramalho-Santos, J
   Zischka, H
   Azul, AM
AF Fontes, Adriana
   Alemany-Pages, Mireia
   Oliveira, Paulo J.
   Ramalho-Santos, Joao
   Zischka, Hans
   Azul, Anabela Marisa
TI Antioxidant Versus Pro-Apoptotic Effects of Mushroom-Enriched Diets on
   Mitochondria in Liver Disease
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE mitochondria; non-alcoholic fatty liver disease; fungi; mushrooms;
   truffles; antioxidants; oxidative stress; lipid metabolism; apoptosis;
   NASH; HCC
ID NONALCOHOLIC-FATTY-LIVER; GANODERMA-LUCIDUM POLYSACCHARIDES; MONOCYTE
   CHEMOATTRACTANT PROTEIN-1; APPRECIATED CULTIVATED MUSHROOMS; IN-VITRO
   ANTIOXIDANT; DE-NOVO LIPOGENESIS; OXIDATIVE STRESS; INSULIN-RESISTANCE;
   HEPATOCELLULAR-CARCINOMA; CHEMICAL-CHARACTERIZATION
AB Mitochondria play a central role in non-alcoholic fatty liver disease (NAFLD) progression and in the control of cell death signalling during the progression to hepatocellular carcinoma (HCC). Associated with the metabolic syndrome, NAFLD is mostly driven by insulin-resistant white adipose tissue lipolysis that results in an increased hepatic fatty acid influx and the ectopic accumulation of fat in the liver. Upregulation of beta-oxidation as one compensatory mechanism leads to an increase in mitochondrial tricarboxylic acid cycle flux and ATP generation. The progression of NAFLD is associated with alterations in the mitochondrial molecular composition and respiratory capacity, which increases their vulnerability to different stressors, including calcium and pro-inflammatory molecules, which result in an increased generation of reactive oxygen species (ROS) that, altogether, may ultimately lead to mitochondrial dysfunction. This may activate further pro-inflammatory pathways involved in the progression from steatosis to steatohepatitis (NASH). Mushroom-enriched diets, or the administration of their isolated bioactive compounds, have been shown to display beneficial effects on insulin resistance, hepatic steatosis, oxidative stress, and inflammation by regulating nutrient uptake and lipid metabolism as well as modulating the antioxidant activity of the cell. In addition, the gut microbiota has also been described to be modulated by mushroom bioactive molecules, with implications in reducing liver inflammation during NAFLD progression. Dietary mushroom extracts have been reported to have anti-tumorigenic properties and to induce cell-death via the mitochondrial apoptosis pathway. This calls for particular attention to the potential therapeutic properties of these natural compounds which may push the development of novel pharmacological options to treat NASH and HCC. We here review the diverse effects of mushroom-enriched diets in liver disease, emphasizing those effects that are dependent on mitochondria.
C1 [Fontes, Adriana; Zischka, Hans] German Res Ctr Environm Hlth, Helmholtz Ctr Munich, Inst Mol Toxicol & Pharmacol, D-85764 Neuherberg, Germany.
   [Fontes, Adriana; Alemany-Pages, Mireia; Oliveira, Paulo J.; Ramalho-Santos, Joao; Azul, Anabela Marisa] Univ Coimbra, CNC Ctr Neurosci & Cell Biol, P-3004504 Coimbra, Portugal.
   [Fontes, Adriana] Univ Coimbra, Fac Sci & Technol, DCV Dept Life Sci, P-3000456 Coimbra, Portugal.
   [Alemany-Pages, Mireia; Oliveira, Paulo J.; Azul, Anabela Marisa] Univ Coimbra, IIIUC Inst Interdisciplinary Res, P-3030789 Coimbra, Portugal.
   [Ramalho-Santos, Joao; Zischka, Hans] Tech Univ Munich, Inst Toxicol & Environm Hyg, D-80802 Munich, Germany.
C3 Helmholtz Association; Helmholtz-Center Munich - German Research Center
   for Environmental Health; Universidade de Coimbra; Universidade de
   Coimbra; Universidade de Coimbra; Technical University of Munich
RP Zischka, H (corresponding author), German Res Ctr Environm Hlth, Helmholtz Ctr Munich, Inst Mol Toxicol & Pharmacol, D-85764 Neuherberg, Germany.; Zischka, H (corresponding author), Tech Univ Munich, Inst Toxicol & Environm Hyg, D-80802 Munich, Germany.
EM zischka@helmholtz-muenchen.de
RI Oliveira, Paulo/AAQ-8943-2020; Zischka, Hans/M-1490-2017; Oliveira,
   Paulo/H-1980-2011; Azul, Anabela Marisa/AFP-5802-2022; Ramalho-Santos,
   Joao/F-8641-2012
OI Alemany i Pages, Mireia/0000-0002-4419-3532; Zischka,
   Hans/0000-0002-4047-1566; Oliveira, Paulo/0000-0002-5201-9948; Fontes,
   Adriana/0000-0003-0923-9053; Azul, Anabela Marisa/0000-0003-3295-1284;
   Ramalho-Santos, Joao/0000-0002-1172-4018
FU FOIE GRAS project - European Union's Horizon 2020, Research and
   Innovation programme under the Marie Sklodowska-Curie Grant [722619]
FX This study received support from the FOIE GRAS project, funded by the
   European Union's Horizon 2020, Research and Innovation programme under
   the Marie Sklodowska-Curie Grant Agreement No. 722619.
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NR 269
TC 19
Z9 20
U1 0
U2 29
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD AUG 2
PY 2019
VL 20
IS 16
AR 3987
DI 10.3390/ijms20163987
PG 35
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA IV6XM
UT WOS:000484411100144
PM 31426291
OA Green Submitted, gold, Green Published
DA 2025-06-11
ER

PT J
AU Ibero-Baraibar, I
   Azqueta, A
   de Cerain, AL
   Martinez, JA
   Zulet, MA
AF Ibero-Baraibar, Idoia
   Azqueta, Amaya
   Lopez de Cerain, Adela
   Alfredo Martinez, J.
   Angeles Zulet, M.
TI Assessment of DNA damage using comet assay in middle-aged
   overweight/obese subjects after following a hypocaloric diet
   supplemented with cocoa extract
SO MUTAGENESIS
LA English
DT Article
ID OXIDATIVE STRESS; METABOLIC SYNDROME; PROTECTION; OBESITY; CELLS;
   INTERVENTION; ANTIOXIDANTS; INFLAMMATION; TRIALS; RISK
AB Nutrient excess and unbalanced diets can result in overproduction of reactive oxygen species (ROS), which are associated with oxidative stress. Cocoa extract contains antioxidants that inhibit the harmful effects of ROS. This trial analysed the effect of cocoa extract consumption integrated as a bioactive compound into ready-to-eat meals, on oxidative stress at the level of DNA in overweight/obese subjects. Fifty volunteers [57.26(5.24) years, 30.59(2.33)kg/m(2)] participated in a 4-week double-blind, randomised, placebo-controlled parallel nutritional intervention. Half of the volunteers received meals supplemented with 1.4g/day cocoa extract, while the other half received control meals, both within a 15% energy restriction diet. Lymphocytes were isolated and endogenous strand breaks, oxidised bases and resistance to H2O2-induced damage were measured by the comet assay. The intake of ready-to-eat meals supplemented with cocoa extract did not show relevant changes in the oxidative status of DNA. However, in the cocoa group, oxidised bases negatively correlated with methyl epicatechin-O-sulphate (r = -0.76; P = -0.007) and epicatechin sulphate (r = -0.61; P = -0.046). When volunteers of both groups were analysed together, a marginal decrease (P = 0.072) in oxidised bases was observed, which attributed to weight loss. Subjects who started the intervention with higher levels of damage showed a greater reduction in oxidised bases after 4 weeks (P = 0.040) compared to those who had lower baseline levels. In conclusion, even if 1.4g of cocoa supplementation for 4 weeks did not show notable changes in terms of antioxidant status of DNA, the energy restriction showed a slightly decrease in oxidised bases and this was seen to a greater extent in subjects who started the intervention with higher levels of damage. On the other hand, the inverse associations found between oxidised bases and some cocoa-derived metabolites suggest that a protective effect might be seen in a longer period of time or in subjects with higher baseline DNA damage. Trial registration: (NCT01596309).
C1 [Ibero-Baraibar, Idoia; Alfredo Martinez, J.; Angeles Zulet, M.] Univ Navarra, Nutr Res Ctr, Dept Nutr Food Sci & Physiol, Navarra 31008, Spain.
   [Azqueta, Amaya; Lopez de Cerain, Adela] Univ Navarra, Dept Pharmacol & Toxicol, Pamplona 31008, Spain.
   [Alfredo Martinez, J.; Angeles Zulet, M.] Carlos III Hlth Res Inst, CIBERobn, Madrid 28029, Spain.
C3 University of Navarra; University of Navarra; CIBER - Centro de
   Investigacion Biomedica en Red; CIBEROBN
RP Martinez, JA (corresponding author), Univ Navarra, Nutr Res Ctr, Dept Nutr Food Sci & Physiol, C Irunlarrea 1, Navarra 31008, Spain.
EM jalfmtz@unav.es
RI Lopez de Cerain, Adela/L-4572-2014; Martinez Hernandez, J
   Alfredo/K-8709-2014; Zulet, M. Angeles/H-1317-2017; Azqueta,
   Amaya/P-7711-2017
OI Lopez de Cerain, Adela/0000-0002-2085-1289; Martinez Hernandez, J
   Alfredo/0000-0001-5218-6941; Zulet, M. Angeles/0000-0002-3926-0892;
   Ibero-Baraibar, Idoia/0000-0003-0091-8068; Azqueta,
   Amaya/0000-0003-4857-9931
FU Centre for Industrial Technological Development within National
   Strategic Consortia for Technical Research; University of Navarra
   [LE/97]; Physiopathology of Obesity and Nutrition (CIBERobn), Carlos III
   Health Research Institute [CB12/03/30002]; Asociacion de Amigos de la
   Universidad de Navarra
FX This work was supported by The Centre for Industrial Technological
   Development within National Strategic Consortia for Technical Research
   (Industrial Research diets and food with specific characteristics for
   elderly SENIFOOD) as well as the University of Navarra LE/97 and
   Physiopathology of Obesity and Nutrition (CIBERobn), Carlos III Health
   Research Institute (CB12/03/30002). Predoctoral scholarship from
   Asociacion de Amigos de la Universidad de Navarra to I.I.-B.
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NR 42
TC 17
Z9 19
U1 1
U2 14
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0267-8357
EI 1464-3804
J9 MUTAGENESIS
JI Mutagenesis
PD JAN
PY 2015
VL 30
IS 1
BP 139
EP 146
DI 10.1093/mutage/geu056
PG 8
WC Genetics & Heredity; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Genetics & Heredity; Toxicology
GA CC0WF
UT WOS:000350058700016
PM 25527736
OA Bronze
DA 2025-06-11
ER

PT J
AU Shevalye, H
   Lupachyk, S
   Watcho, P
   Stavniichuk, R
   Khazim, K
   Abboud, HE
   Obrosova, IG
AF Shevalye, Hanna
   Lupachyk, Sergey
   Watcho, Pierre
   Stavniichuk, Roman
   Khazim, Khaled
   Abboud, Hanna E.
   Obrosova, Irina G.
TI Prediabetic Nephropathy as an Early Consequence of the
   High-Calorie/High-Fat Diet: Relation to Oxidative Stress
SO ENDOCRINOLOGY
LA English
DT Article
ID ENDOPLASMIC-RETICULUM-STRESS; DIABETIC KIDNEY-DISEASE; ALDOSE REDUCTASE
   INHIBITION; CARDIOVASCULAR RISK-FACTORS; IMPAIRED GLUCOSE-TOLERANCE;
   INSULIN-RESISTANCE; PROTEIN-KINASE; MESANGIAL EXPANSION; METABOLIC
   SYNDROME; PODOCYTE INJURY
AB This study evaluated early renal functional, structural, and biochemical changes in high-calorie/high-fat diet fed mice, a model of prediabetes and alimentary obesity. Male C57BL6/J mice were fed normal (11 kcal% fat) or high-fat (58 kcal% fat) diets for 16 wk. Renal changes were evaluated by histochemistry and immunohistochemistry, Western blot analysis, ELISA, enzymatic assays, and chemiluminometry. High-fat diet consumption led to increased body and kidney weights, impaired glucose tolerance, hyperinsulinemia, polyuria, a 2.7-fold increase in 24-h urinary albumin excretion, 20% increase in renal glomerular volume, 18% increase in renal collagen deposition, and 8% drop of glomerular podocytes. It also resulted in a 5.3-fold increase in urinary 8-isoprostane excretion and a 38% increase in renal cortex 4-hydroxynonenal adduct accumulation. 4-hydroxynonenal adduct level and immunoreactivity or Sirtuin 1 expression in renal medulla were not affected. Studies of potential mechanisms of the high-fat diet induced renal cortex oxidative injury revealed that whereas nicotinamide adenine dinucleotide phosphate reduced form oxidase activity only tended to increase, 12/15-lipoxygenase was significantly up-regulated, with approximately 12% increase in the enzyme protein expression and approximately 2-fold accumulation of 12(S)-hydroxyeicosatetraenoic acid, a marker of 12/15-lipoxygenase activity. Accumulation of periodic acid-Schiff -positive material, concentrations of TGF-beta, sorbitol pathway intermediates, and expression of nephrin, CAAT/enhancer-binding protein homologous protein, phosphoeukaryotic initiation factor-alpha, and total eukaryotic initiation factor-alpha in the renal cortex were indistinguishable between experimental groups. Vascular endothelial growth factor concentrations were reduced in high-fat diet fed mice. In conclusion, systemic and renal cortex oxidative stress associated with 12/15-lipoxygenase overexpression and activation is an early phenomenon caused by high-calorie/high-fat diet consumption and a likely contributor to kidney disease associated with prediabetes and alimentary obesity. (Endocrinology 153: 1152-1161, 2012)
C1 [Shevalye, Hanna; Lupachyk, Sergey; Watcho, Pierre; Stavniichuk, Roman; Obrosova, Irina G.] Louisiana State Univ Syst, Pennington Biomed Res Ctr, Baton Rouge, LA 70808 USA.
   [Khazim, Khaled; Abboud, Hanna E.] Univ Texas Hlth Sci Ctr San Antonio, Dept Med, Div Nephrol, San Antonio, TX 78229 USA.
C3 Louisiana State University System; Louisiana State University;
   Pennington Biomedical Research Center; University of Texas System;
   University of Texas Health Science Center at San Antonio
RP Obrosova, IG (corresponding author), Louisiana State Univ, Pennington Biomed Res Ctr, 6400 Perkins Rd, Baton Rouge, LA 70808 USA.
EM obrosoig@pbrc.edu
OI Shevalye, Hanna/0000-0002-2963-1717
FU National Institutes of Health (NIH) [RO1DK074517, RO1DK077141,
   RO1DK081147]; American Diabetes Association [7-08-RA-102, RO1DK078971];
   Center of Biomedical Research Excellence (NIH) [P20 RR021945]; Nutrition
   and Obesity Research Center (NIH) [1P30-DK072476]
FX This work was supported by the National Institutes of Health (NIH)
   Grants RO1DK074517, RO1DK077141, and RO1DK081147, and the American
   Diabetes Association Research Grants 7-08-RA-102 (all to I.G.O.) and
   RO1DK078971 (to H.E.A.). The Cell Biology and Bioimaging Core used in
   this work is supported in part by Center of Biomedical Research
   Excellence (NIH Grant P20 RR021945) and Nutrition and Obesity Research
   Center (NIH Grant 1P30-DK072476) grants from the NIH.
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NR 59
TC 40
Z9 47
U1 0
U2 19
PU ENDOCRINE SOC
PI CHEVY CHASE
PA 8401 CONNECTICUT AVE, SUITE 900, CHEVY CHASE, MD 20815-5817 USA
SN 0013-7227
J9 ENDOCRINOLOGY
JI Endocrinology
PD MAR
PY 2012
VL 153
IS 3
BP 1152
EP 1161
DI 10.1210/en.2011-1997
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 897JG
UT WOS:000300645600021
PM 22234462
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Jankord, R
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   Hamilton, MT
   Laughlin, MH
AF Jankord, Ryan
   Ganjam, Venkataseshu K.
   Turk, James R.
   Hamilton, Marc T.
   Laughlin, M. Harold
TI Exercise training alters effect of high-fat feeding on the ACTH stress
   response in pigs
SO APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
LA English
DT Article
DE HPA axis; stress; ACTH; fat diet; cortisol; free fatty acids
ID PITUITARY-ADRENOCORTICAL AXIS; CORONARY-HEART-DISEASE; SERUM-ALBUMIN;
   ENDOTHELIAL FUNCTION; CARDIOVASCULAR-DISEASE; CORTISOL SECRETION;
   METABOLIC SYNDROME; MORTALITY; RISK; DIET
AB Eating and physical activity behaviors influence neuroendocrine output. The purpose of this study was to test, in an animal model of diet-induced cardiovascular disease, the effects of high-fat feeding and exercise training on hypothalamo-pituitary-adrenocortical (IIPA) axis activity. We hypothesized that a high-fat diet would increase circulating free fatty acids (FFAs) and decrease the adrenocorticotropic hormone (ACTH) and cortisol response to an acute stressor. We also hypothesized that exercise training would reverse the high-fat diet-induced changes in FFAs and thereby restore the ACTH and cortisol response. Pigs were placed in 1 of 4 groups (normal diet, sedentary; normal diet, exercise training; high-fat diet, sedentary; high-fat diet, exercise training; n = 8/group). Animals were placed on their respective dietary and activity treatments for 16-20 weeks. After completion of the treatments animals were anesthetized and underwent surgical intubation. Blood samples were collected after surgery and the ACTH and cortisol response to surgery was determined and the circulating concentrations of FFAs, glucose, cholesterol, insulin, and IGF-1 were measured. Consistent with our hypothesis, high-fat feeding increased FFAs by 200% and decreased the ACTH stress response by 40%. In exercise-trained animals, the high-fat diet also increased FFA; however, the increase in FFA in exercise-trained pigs was accompanied by a 60% increase in the ACTH response. The divergent effect of high-fat feeding on ACTH response was not expected, as exercise training alone had no effect on the ACTH response. Results demonstrate a significant interaction between diet and exercise and their effect on the ACTH response. The divergent effects of high-fat diet could not be explained by changes in weight gain, blood glucose, insulin, or IGF-1, as these were altered by high-fat feeding, but unaffected by exercise training. Thus, the increase in FFA with high-fat feeding may explain the blunted ACTH response to an acute stressor in sedentary animals, but cannot explain the exaggerated response in exercise trained animals.
C1 [Jankord, Ryan; Ganjam, Venkataseshu K.; Turk, James R.; Hamilton, Marc T.; Laughlin, M. Harold] Univ Missouri, Coll Vet Med, Dept Biomed Sci, Columbia, MO 65211 USA.
C3 University of Missouri System; University of Missouri Columbia
RP Jankord, R (corresponding author), Univ Cincinnati, Genome Res Inst, Dept Psychiat, E205,2170 E Galbraith Rd, Cincinnati, OH 45237 USA.
EM ryan.jankord@uc.edu
RI Hamilton, Marc/KIC-9374-2024
OI Hamilton, Marc/0000-0003-0982-7859
FU NHLBI NIH HHS [R01 HL036088, P01 HL052490, HL-52490, HL-36088] Funding
   Source: Medline; NIAMS NIH HHS [T32 AR048523, AR-048523] Funding Source:
   Medline
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NR 45
TC 8
Z9 9
U1 0
U2 8
PU CANADIAN SCIENCE PUBLISHING
PI OTTAWA
PA 65 AURIGA DR, SUITE 203, OTTAWA, ON K2E 7W6, CANADA
SN 1715-5312
EI 1715-5320
J9 APPL PHYSIOL NUTR ME
JI Appl. Physiol. Nutr. Metab.
PD JUN
PY 2008
VL 33
IS 3
BP 461
EP 469
DI 10.1139/H08-022
PG 9
WC Nutrition & Dietetics; Physiology; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics; Physiology; Sport Sciences
GA 298LY
UT WOS:000255690400005
PM 18461098
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Arrari, F
   Jabri, MA
   Ayari, A
   Dakhli, N
   Ben Fayala, C
   Boubaker, S
   Sebai, H
AF Arrari, Fatma
   Jabri, Mohamed -Amine
   Ayari, Ala
   Dakhli, Nouha
   Ben Fayala, Chayma
   Boubaker, Samir
   Sebai, Hichem
TI Amino acid HPLC-FLD analysis of spirulina and its protective mechanism
   against the combination of obesity and colitis in wistar rats
SO HELIYON
LA English
DT Article
DE Obesity; Ulcerative colitis; Spirulina; Oxidative stress; Cafeteria diet
ID INFLAMMATORY-BOWEL-DISEASE; INDUCED ULCERATIVE-COLITIS; SEED AQUEOUS
   EXTRACT; DIET-INDUCED OBESITY; ACETIC-ACID; ANTIOXIDANT ACTIVITY;
   ADIPOSE-TISSUE; METABOLIC SYNDROME; HEMORRHAGIC-SHOCK; OXIDATIVE STRESS
AB Objective: The cafeteria diet (CD), designed as an experimental diet mimicking the obesogenic diet, may contribute to the pathogenesis of inflammatory bowel diseases (IBD). This study delves into the influence of spirulina (SP) on obesity associated with colitis in Wistar rats. Methods: The amino acids composition of SP was analyzed using HPLC-FLD. Animals were equally separated into eight groups, each containing seven animals and treated daily for eight weeks as follows: Control diet (SD), cafeteria diet (CD) group, CD + SP (500 mg/kg) and SD + SP. Ulcerative colitis was provoked by rectal injection of acetic acid (AA) (3 % v/v, 5 ml/kg b.w.) on the last day of treatment in the following groups: SD + AA, SD + AA + SP, CD + AA, and CD + AA + SP. Results: Findings revealed that UC and/or CD increased the abdominal fat, weights gain, and colons. Moreover, severe colonic alteration, perturbations in the serum metabolic parameters associated with an oxidative stress state in the colonic mucosa, defined by overproduction of reactive oxygen species (ROS) and increased levels of plasma scavenging activity (PSA). Additionally, obesity exacerbated the severity of AA-induced UC promoting inflammation marked by the overexpression of pro-inflammatory cytokines. Significantly, treatment with SP provided notable protection against inflammation severity, reduced histopathological alterations, attenuated lipid peroxidation (MDA), and enhanced antioxidant enzyme activities (CAT, SOD, and GPX) along with non-enzymatic antioxidants (GSH and SH-G). Conclusions: Thus, the antioxidant effects and anti-inflammatory proprieties of SP could be attributed to its richness in amino acids, which could potentially mitigate inflammation severity in obese subjects suffering from ulcerative colitis. These results imply that SP hold promise as a therapeutic agent for managing of UC, particularly in individuals with concomitant obesity. Understanding SP's mechanisms of action may lead novel treatment strategies for inflammatory bowel diseases and hyperlipidemia in medical research.
C1 [Arrari, Fatma; Jabri, Mohamed -Amine; Ayari, Ala; Dakhli, Nouha; Sebai, Hichem] Univ Jendouba, Inst Super Biotechnol Beja, LR Physiol Fonct & Valorisat Bioressources, Beja 9000, Tunisia.
   [Ben Fayala, Chayma; Boubaker, Samir] Inst Pasteur Tunis, Lab Anat Pathol Humaine & Experimentale, 13, Pl Pasteur, Tunis 1002, Tunisia.
   [Arrari, Fatma] Inst Super Biotechnol Beja, Lab Physiol Fonct & Valorisat Bioressources, Ave Habib Bourguiba,BP 382, Beja 9000, Tunisia.
C3 Universite de Jendouba; Pasteur Network; Universite de Tunis-El-Manar;
   Institut Pasteur Tunis; Universite de Jendouba
RP Arrari, F (corresponding author), Inst Super Biotechnol Beja, Lab Physiol Fonct & Valorisat Bioressources, Ave Habib Bourguiba,BP 382, Beja 9000, Tunisia.
EM fatma.arrari90@gmail.com
RI Arrari, Fatma/KIJ-4885-2024
OI Arrari, Fatma/0000-0002-6207-4641
FU Tunisian Ministry of Higher Education and Scientific Research
FX The author declared receipt of financial support from the Tunisian
   Ministry of Higher Education and Scientific Research.
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NR 121
TC 3
Z9 3
U1 2
U2 11
PU CELL PRESS
PI CAMBRIDGE
PA 50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA
EI 2405-8440
J9 HELIYON
JI Heliyon
PD MAY 15
PY 2024
VL 10
IS 9
AR e30103
DI 10.1016/j.heliyon.2024.e30103
EA APR 2024
PG 16
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA SW2K3
UT WOS:001237418400001
PM 38694088
OA gold
DA 2025-06-11
ER

PT J
AU Zhu, DL
   Du, YY
   Zhu, LL
   Alahmadi, TA
   Hussein-Al-Ali, SH
   Wang, QH
AF Zhu, Dongli
   Du, Yuanyuan
   Zhu, Lili
   Alahmadi, Tahani Awad
   Hussein-Al-Ali, Samer Hasan
   Wang, Qinhu
TI Testosterone with Silymarin Improves Diabetes-obesity Comorbidity
   Complications by Modulating Inflammatory Responses and CYP7A1/ACC Gene
   Expressions in Rats
SO COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING
LA English
DT Article
DE Diabetes; obesity; silymarin; testosterone; oxidative stress; CYP7A1
ID INSULIN-RESISTANCE; OXIDATIVE STRESS; CHOLESTEROL 7-ALPHA-HYDROXYLASE;
   METABOLIC SYNDROME; ACID SYNTHESIS; MEN; ADIPONECTIN; THERAPY;
   REPLACEMENT; STEATOSIS
AB Background: The co-morbidity of DMOB has become increasingly problematic among the world's population because of a high-calorie diet and sedentary lifestyle. DMOB is associated with lower testosterone (TN) levels, the male sex hormone. The phytochemical compound silymarin (SN) exerts antidiabetic activity by modifying beta -cells and anti-obesity activity by inhibiting adipogenesis by methylxanthine. Aim: The goal of this study was to find out how well testosterone (TN) with silymarin (SN) protects against oxidative stress and inflammation in the liver of the experimental rats with type 2 diabetes (T2D) and obesity (DMOB). Objectives: The present study evaluates the efficacy of TN and SN combination (TNSN) on the levels of the potential parameters, such as body mass, serum marker enzymes, fasting glucose levels, HbA1c levels, lipid profile, enzymatic and non-enzymatic antioxidants, proinflammatory cytokines, gene expression pathways, and histopathology in a DMOB comorbidity rat model. Methods: Male Sprague-Dawley (SD) rats were fed a high-fat diet (HFD) for 20 weeks with an administration of a single dose of streptozotocin (STZ) i.p. injection (30 mg/kg) on the 9th week of the study. The procedure was to develop the DMOB co-morbidity model in the experimental animals. Co-treatment of TN and SN administration were followed throughout the experiment. Rats were sacrificed after overnight fasting to collect serum and liver tissue samples. Samples were analyzed using a clinical chemistry automated analyzer, spectrophotometry, and quantitative real-time PCR (qPCR) methods and protocols. Results: Analyses of body mass changes, serum marker enzymes, fasting glucose levels, HbA1c levels, lipid profiles, enzymatic and non-enzymatic antioxidants, TNF-alpha, IL-6, adiponectin, CYP7A1, ACC expression pathways, and histopathology showed significant abnormal levels (P <= 0.05) in the pathological group. These were efficiently treated to normal by the administration of TNSN. Conclusion: These results concluded that TNSN exerted protective efficacy against the liver abnormalities in the co-morbidity of the DMOB rat model.
C1 [Zhu, Dongli; Du, Yuanyuan] Daqing Oilfield Gen Hosp, Dept Endocrinol, Daqing 163000, Heilongjiang, Peoples R China.
   [Zhu, Lili] Yantai Penglai Peoples Hosp, Dept Endocrinol, Yantai 265600, Shandong, Peoples R China.
   [Alahmadi, Tahani Awad] King Saud Univ, Dept Pediat, Coll Med, Riyadh 11461, Saudi Arabia.
   [Alahmadi, Tahani Awad] King Saud Univ, King Khalid Univ Hosp, Riyadh 11461, Saudi Arabia.
   [Hussein-Al-Ali, Samer Hasan] Isra Univ, Dept Chem, Fac Sci, Amman 11622, Jordan.
   [Wang, Qinhu] Third Peoples Hosp Gansu Prov, Dept Endocrinol, Lanzhou 730000, Gansu, Peoples R China.
C3 King Saud University; King Saud University; King Khalid University
   Hospital; Isra University
RP Wang, QH (corresponding author), Third Peoples Hosp Gansu Prov, Dept Endocrinol, Lanzhou 730000, Gansu, Peoples R China.
EM qwang02@hotmail.com
RI Hussein-Al-Ali, Samer/AAJ-2861-2020
FX All the authors acknowledge the support extended by the Department of
   Endocrinology, The Third People's Hospital of Gansu Province, Lanzhou,
   Gansu Province, 730000 China,s for providing infrastructure facilities
   for this research.
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NR 76
TC 1
Z9 1
U1 1
U2 6
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1386-2073
EI 1875-5402
J9 COMB CHEM HIGH T SCR
JI Comb. Chem. High Throughput Screen
PY 2024
VL 27
IS 13
BP 1999
EP 2012
DI 10.2174/0113862073272401231108054024
PG 14
WC Biochemical Research Methods; Chemistry, Applied; Pharmacology &
   Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry; Pharmacology & Pharmacy
GA WE3G3
UT WOS:001253147300012
PM 37957854
DA 2025-06-11
ER

PT J
AU Manzoni, AG
   Passos, DF
   Leitemperger, JW
   Storck, TR
   Doleski, PH
   Jantsch, MH
   Loro, VL
   Leal, DBR
AF Manzoni, Alessandra G.
   Passos, Daniela F.
   Leitemperger, Jossiele W.
   Storck, Tamiris R.
   Doleski, Pedro H.
   Jantsch, Matheus H.
   Loro, Vania L.
   Leal, Daniela B. R.
TI Hyperlipidemia-induced lipotoxicity and immune activation in rats are
   prevented by curcumin and rutin
SO INTERNATIONAL IMMUNOPHARMACOLOGY
LA English
DT Article
DE Hyperlipidemia; Immune activation; Adenosine deaminase; Antioxidants;
   Lipotoxicity; Oxidative stress
ID OXIDATIVE STRESS; URIC-ACID; METABOLIC SYNDROME; LIPID-METABOLISM;
   INFLAMMATION; SPLEEN; HYPERGLYCEMIA; POLYPHENOLS; MECHANISMS; FLAVONOIDS
AB We assessed the effects of curcumin, rutin, and the association of rutin and curcumin in organs of hyperlipidemic rats. Rutin and curcumin have notable antioxidant and anti-inflammatory actions, so we hypothesized that their association would enhance their beneficial effects. Hyperlipidemia results in lipotoxicity and affects several organs. Lipotoxicity is not only an outcome of lipid accumulation in non-adipose tissues but also a result of the hyperlipidemia-associated inflammation and oxidative stress. Wistar rats were treated with rutin and curcumin for 30 days before the induction of acute hyperlipidemia by Poloxamer-407. After 36 h, the animals were euthanized for collection of blood and organs. Untreated hyperlipidemic rats showed higher uric acid and albumin levels in the serum and increased spleen size and ADA activity. Rutin, curcumin and the association reduced the spleen size by 20% and ADA activity by 23, 28, and 27%, respectively. Rats pretreated with rutin showed reduced lipid damage in the liver (40%) and the kidney (44%), and the protein damage was also reduced in the liver (75%). The lipid damage was decreased by 40% in the liver, and 56% in the kidney of rats pretreated with curcumin. The association reduced lipid damage by 50% and 36%, and protein damage by 77% and 64% in the liver and kidney, respectively. Rutin better prevented the decrease in the antioxidant defenses, increasing SOD by 34%, CAT by 246% and GST by 84% in the liver, as well as SOD by 119% and GST by 190% in the kidney. Also, analyses of blood and spleen parameters of untreated and pretreated non-hyperlipidemic rats showed no signs of immunotoxicity. Despite showing protective effects, the association did not perform better than the isolated compounds. Here, we showed that rutin and/or curcumin reestablished the immune homeostasis and redox balance disrupted by hyperlipidemia in peripheral organs of rats.
C1 [Manzoni, Alessandra G.; Passos, Daniela F.; Doleski, Pedro H.; Jantsch, Matheus H.; Leal, Daniela B. R.] Univ Fed Santa Maria, Ctr Ciencias Saude, Dept Microbiol & Parasitol, Lab Imunobiol Expt & Aplicada LABIBIO, Santa Maria, RS, Brazil.
   [Manzoni, Alessandra G.; Passos, Daniela F.; Leitemperger, Jossiele W.; Doleski, Pedro H.; Loro, Vania L.; Leal, Daniela B. R.] Univ Fed Santa Maria, Ctr Ciencias Nat & Exatas, Programa Posgrad Bioquim Toxicol, Santa Maria, RS, Brazil.
   [Leitemperger, Jossiele W.; Storck, Tamiris R.; Loro, Vania L.] Univ Fed Santa Maria, Dept Bioquim & Biol Mol, Lab Toxicol Aquat, Santa Maria, RS, Brazil.
C3 Universidade Federal de Santa Maria (UFSM); Universidade Federal de
   Santa Maria (UFSM); Universidade Federal de Santa Maria (UFSM)
RP Leal, DBR (corresponding author), Univ Fed Santa Maria, Ctr Ciencias Saude, Dept Microbiol & Parasitol, Santa Maria, RS, Brazil.
EM daniela.leal@ufsm.br
RI LEAL, DANIELA/G-9391-2012; Loro, Vania/E-9387-2015; leal,
   Daniela/C-2700-2016; Rosso Storck, Tamiris/P-7952-2018
OI Jantsch, Matheus Henrique/0000-0001-8663-057X; leal,
   Daniela/0000-0003-2618-9801; Rosso Storck, Tamiris/0000-0002-8547-1340
FU Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior - Brasil
   (CAPES) [001, 88882.182184/2018-01]
FX This study was financed in part by the Coordenacao de Aperfeicoamento de
   Pessoal de Nivel Superior - Brasil (CAPES) (Finance Code 001. PROEX
   number 88882.182184/2018-01).
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NR 60
TC 23
Z9 26
U1 3
U2 20
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1567-5769
EI 1878-1705
J9 INT IMMUNOPHARMACOL
JI Int. Immunopharmacol.
PD APR
PY 2020
VL 81
AR 106217
DI 10.1016/j.intimp.2020.106217
PG 9
WC Immunology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Pharmacology & Pharmacy
GA LG1TN
UT WOS:000527892200042
PM 32007794
OA hybrid
DA 2025-06-11
ER

PT J
AU Tsai, CC
   Lin, YJ
   Yu, HR
   Sheen, JM
   Tain, YL
   Huang, LT
   Tiao, MM
AF Tsai, Ching-Chou
   Lin, Yu-Ju
   Yu, Hong-Ren
   Sheen, Jiunn-Ming
   Tain, You-Lin
   Huang, Li-Tung
   Tiao, Mao-Meng
TI Melatonin alleviates liver steatosis induced by prenatal dexamethasone
   exposure and postnatal high-fat diet
SO EXPERIMENTAL AND THERAPEUTIC MEDICINE
LA English
DT Article
DE high-fat diet; liver steatosis; dexamethasone; melatonin; obesity
ID OXIDATIVE STRESS; INSULIN-RESISTANCE; METABOLIC SYNDROME; OB/OB MICE;
   DISEASE; OBESITY; RATS; APOPTOSIS; CYTOKINES; PATHWAY
AB Prenatal exposure to glucocorticoids is associated with negative health consequences for the offspring that persist into adulthood, including liver steatosis. Melatonin has previously been demonstrated to suppress liver steatosis and oxidative stress in humans with non-alcoholic fatty liver disease and in animal models of obesity. The present study aimed to determine whether melatonin protects against liver steatosis induced by prenatal dexamethasone exposure followed by postnatal high-fat diet. Pregnant Sprague-Dawley rats at gestational days 14-21 were administered dexamethasone (0.1 mg/kg/day) or saline via intraperitoneal injection. The offspring were then divided into five groups, as follows: Vehicle, postnatal high-fat diet (VHF), prenatal dexamethasone exposure (DEX), prenatal dexamethasone exposure + postnatal high-fat diet (DHF), and prenatal dexamethasone exposure + postnatal high-fat diet + melatonin (DHFM) group. Following vehicle or dexamethasone exposure of the maternal rats, the offspring rats in the VHF, DHF and DHFM groups received a high-fat diet (58% fat) between weaning and 6 months of age. In the DHFM group, melatonin was administered to the mothers from gestational days 14-21 until weaning. The offspring continued to receive melatonin until they were sacrificed at 6 months old. Oil Red O staining demonstrated stronger intensity in the DHF group compared with that in the other four groups. Western blot analysis also revealed higher levels of cleaved caspase-3, tumor necrosis factor-alpha (TNF-alpha), suppressor of cytokine signaling 3 (SOCS3) and malondialdehyde (MDA), as well as reduced expression of manganese superoxide dismutase (MnSOD) and phosphoinositide 3-kinase (PI3K) in the DHF group compared with the vehicle and DHFM groups. In addition, melatonin reduced the Oil Red O staining intensity and the levels of cleaved caspase-3, TNF-alpha, SOCS3 and MDA, while it increased the MnSOD and PI3K levels, in the DHFM group compared with the DHF group. In conclusion, postnatal high-fat diet aggravated the prenatal dexamethasone-induced liver steatosis in adult rat offspring via inflammation, oxidative stress and cellular apoptosis, which may be ameliorated by prenatal melatonin therapy.
C1 [Tsai, Ching-Chou; Lin, Yu-Ju] Chang Gung Univ, Kaohsiung Chang Gung Mem Hosp, Coll Med, Dept Obstet & Gynecol, Kaohsiung 83301, Taiwan.
   [Tsai, Ching-Chou] Chiayi Chang Gung Mem Hosp, Dept Obstet & Gynecol, Puzi 61363, Chiayi, Taiwan.
   [Yu, Hong-Ren; Sheen, Jiunn-Ming; Tain, You-Lin; Huang, Li-Tung; Tiao, Mao-Meng] Chang Gung Univ, Kaohsiung Chang Gung Mem Hosp, Coll Med, Dept Pediat, 123 Ta Pei Rd, Kaohsiung 83301, Taiwan.
   [Tain, You-Lin] Chang Gung Univ, Kaohsiung Chang Gung Mem Hosp, Coll Med, Inst Translat Res Biomed, Kaohsiung 83301, Taiwan.
C3 Chang Gung Memorial Hospital; Chang Gung University; Chang Gung Memorial
   Hospital; Chang Gung Memorial Hospital; Chang Gung University; Chang
   Gung University; Chang Gung Memorial Hospital
RP Huang, LT; Tiao, MM (corresponding author), Chang Gung Univ, Kaohsiung Chang Gung Mem Hosp, Coll Med, Dept Pediat, 123 Ta Pei Rd, Kaohsiung 83301, Taiwan.
EM litung.huang@gmail.com; tmm@cgmh.org.tw
RI Tain, You-Lin/H-2827-2019; yu, hong-ren/KII-6665-2024
OI Tain, You-Lin/0000-0002-7059-6407
FU Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan [CMRPG8C0841,
   CMRPG8F0131, CMRPG8E0641]
FX The present study was supported by grants from the Kaohsiung Chang Gung
   Memorial Hospital, Kaohsiung, Taiwan (nos. CMRPG8C0841, CMRPG8F0131 and
   CMRPG8E0641).
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NR 48
TC 13
Z9 14
U1 0
U2 1
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1792-0981
EI 1792-1015
J9 EXP THER MED
JI Exp. Ther. Med.
PD AUG
PY 2018
VL 16
IS 2
BP 917
EP 924
DI 10.3892/etm.2018.6256
PG 8
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA GR1GO
UT WOS:000442280500063
PM 30112044
OA Green Published, gold
DA 2025-06-11
ER

PT S
AU Engin, A
AF Engin, Atilla
BE Engin, AB
   Engin, A
TI Non-Alcoholic Fatty Liver Disease
SO OBESITY AND LIPOTOXICITY
SE Advances in Experimental Medicine and Biology
LA English
DT Article; Book Chapter
DE Acetyl-CoA carboxylase (ACC) 1; Atypical protein kinase C (aPKC);
   Autophagy; Ceramide; Cirrhosis; Diacylglycerol (DAG); Diacylglycerol
   acyltransferase (DGAT); Fatty acid synthase (FAS); Hepatic steatosis;
   Mammalian target of rapamycin complex 1 (mTORC1); Non-alcoholic fatty
   liver disease (NAFLD); Non-alcoholic steatohepatitis (NASH); Obesity;
   Protein kinase C (PKC); Serum alanine aminotransferase (ALT); Sterol
   regulatory element-binding protein-1c (SREBP-1c); Triglyceride; Tumor
   necrosis factor-alpha (TNF-alpha); Unfolded protein response (UPR)
ID HEPATIC INSULIN-RESISTANCE; VISCERAL ADIPOSITY INDEX; UNFOLDED PROTEIN
   RESPONSE; ACETYL-COA CARBOXYLASE-1; DISULFIDE-BOND FORMATION; DE-NOVO
   LIPOGENESIS; OXIDATIVE STRESS; MITOCHONDRIAL DYSFUNCTION; TRANSCRIPTION
   FACTOR; METABOLIC SYNDROME
AB Non-alcoholic fatty liver disease (NAFLD) is in parallel with the obesity epidemic and it is the most common cause of liver diseases. The development of hepatic steatosis in majority of patients is linked to dietary fat ingestion. NAFLD is characterized by excess accumulation of triglyceride in the hepatocyte due to both increased inflow of free fatty acids and de novo hepatic lipogenesis. Insulin resistance with the deficiency of insulin receptor substrate-2 (IRS-2)-associated phosphatidylinositol 3-kinase (PI3K) activity causes an increase in intracellular fatty acid-derived metabolites such as diacylglycerol, fatty acyl CoA or ceramides. Lipotoxicity-related mechanism of NAFLD could be explained still best by the "double-hit" hypothesis. Insulin resistance is the major mechanism in the development and progression of NAFLD/Non-alcoholic steatohepatitis (NASH). Metabolic oxidative stress, autophagy, and inflammation induce NASH progression. In the "first hit" the hepatic concentrations of diacylglycerol increase with rising saturated liver fat content in human NAFLD. Activities of mitochondrial respiratory chain complexes are decreased in liver tissue of patients with NASH. Furthermore, hepatocyte lipoapoptosis is a critical feature of NASH. In "second hit" reduced glutathione levels due to oxidative stress lead to overactivation of c-Jun N-terminal kinase (JNK)/c-Jun signaling that induces cell death in the steatotic liver. Accumulation of toxic levels of reactive oxygen species (ROS) is caused by the ineffectual cycling of the endoplasmic reticulum (ER) oxidoreductin (Ero1)-protein disulfide isomerase oxidation cycle through the downstream of the inner membrane mitochondrial oxidative metabolism and Kelch like-ECH-associated protein 1 (Keap1)- Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) pathway.
C1 [Engin, Atilla] Gazi Univ, Dept Gen Surg, Fac Med, Ankara, Turkey.
   [Engin, Atilla] Mustafa Kemal Mah 2137 Sok 8-14, TR-06520 Ankara, Turkey.
C3 Gazi University
RP Engin, A (corresponding author), Gazi Univ, Dept Gen Surg, Fac Med, Ankara, Turkey.; Engin, A (corresponding author), Mustafa Kemal Mah 2137 Sok 8-14, TR-06520 Ankara, Turkey.
EM dr.aengin@gmail.com
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NR 190
TC 197
Z9 218
U1 2
U2 22
PU SPRINGER INTERNATIONAL PUBLISHING AG
PI CHAM
PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND
SN 0065-2598
EI 2214-8019
BN 978-3-319-48382-5; 978-3-319-48380-1
J9 ADV EXP MED BIOL
JI Adv.Exp.Med.Biol.
PY 2017
VL 960
BP 443
EP 467
DI 10.1007/978-3-319-48382-5_19
D2 10.1007/978-3-319-48382-5
PG 25
WC Endocrinology & Metabolism; Medicine, Research & Experimental;
   Physiology
WE Book Citation Index – Science (BKCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Research & Experimental Medicine; Physiology
GA BS6WL
UT WOS:000753914500020
PM 28585211
DA 2025-06-11
ER

PT J
AU Zhang, XC
   Lu, XY
   Zhou, YJ
   Guo, XY
   Chang, YN
AF Zhang, Xiaochen
   Lu, Xinyang
   Zhou, Yingjun
   Guo, Xinyu
   Chang, Yaning
TI Major royal jelly proteins prevents NAFLD by improving mitochondrial
   function and lipid accumulation through activating the AMPK / SIRT3
   pathway in vitro
SO JOURNAL OF FOOD SCIENCE
LA English
DT Article
DE AMPK; SIRT3 signaling pathway; functional food; lipids; major royal
   jelly proteins; oxidation
AB Nonalcoholic fatty liver disease (NAFLD) is a metabolic syndrome, whose main characteristics are excessive lipid accumulation and oxidative stress. Major royal jelly proteins (MRJPs) is a kind of water-soluble protein, which is abundant in royal jelly (RJ). The aim of this study was to evaluate the effect of MRJPs on lipid accumulation and oxidative stress of liver cells. Here, we first optimized the conditions for extracting MRJPs from RJ and identified the extraction effect and product by SDS-PAGE. Then, we used oleic acid (OA) of 1.0 mM to induce hepatocytes for 24 hr to establish a stable cell models of lipid accumulation, and we found that pre-administration (24 hr) of MRJPs (0.2, 0.5, and 1.0 g/L) could significantly reduce the lipid drop content and triglyceride level in the model cells, and simultaneously reduce the alanine aminotransferase and aspertate aminotransferase levels in the cell culture supernatant. In addition, pre-incubation (24 hr) with MRJPs (0.2, 0.5, and 1.0 g/L) could restore superoxide dismutase (SOD) level and mitochondrial membrane potential as compared with OA group. Furthermore, MRJPs administration significantly upregulated the expression of Silent Information Regulator 2 Associated Protein 3, mitochondrial superoxide dismutase (SOD2), and cytochrome c oxidase subunit IV in OA-treated HepG2 cells. The study for the first time provides evidences on the lipid-lowering effect of MRJPs at the cellular level, which can further provide support for the development and application of polypeptide drugs in the future, and can also provide a choice for the prevention and treatment of liver metabolic diseases represented by NAFLD.
   Practical Application Our study proved that MRJPs had substantial preventing effect on OA-induced lipid accumulation and mitochondrial dysfunction in HepG2 cells. This research can further provide theoretical support for the development and application of peptide drugs in the future. Besides, it can not only further broaden our understanding of NAFLD and other diseases, but also provide ideas for research on oxidative stress and lipid accumulation in the body.
C1 [Zhang, Xiaochen; Lu, Xinyang; Zhou, Yingjun; Guo, Xinyu; Chang, Yaning] East China Univ Sci & Technol, State Key Lab Bioreactor Engn Sch Biotechnol, 130 Meilong Rd, Shanghai 200237, Peoples R China.
C3 East China University of Science & Technology
RP Chang, YN (corresponding author), East China Univ Sci & Technol, State Key Lab Bioreactor Engn Sch Biotechnol, 130 Meilong Rd, Shanghai 200237, Peoples R China.
EM changyn@ecust.edu.cn
RI Chang, Ya-Ning/L-1150-2019
OI Zhou, Yingjun/0000-0003-3631-4004
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NR 30
TC 11
Z9 11
U1 0
U2 69
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-1147
EI 1750-3841
J9 J FOOD SCI
JI J. Food Sci.
PD MAR
PY 2021
VL 86
IS 3
BP 1105
EP 1113
DI 10.1111/1750-3841.15625
EA FEB 2021
PG 9
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA QT8PV
UT WOS:000617446000001
PM 33580500
DA 2025-06-11
ER

PT J
AU Shawky, NM
   Shehatou, GSG
   Suddek, GM
   Gameil, NM
AF Shawky, Noha M.
   Shehatou, George S. G.
   Suddek, Ghada M.
   Gameil, Nariman M.
TI Comparison of the effects of sulforaphane and pioglitazone on insulin
   resistance and associated dyslipidemia, hepatosteatosis, and endothelial
   dysfunction in fructose-fed rats
SO ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
LA English
DT Article
DE Sulforaphane; Insulin resistance; Lipid profile; Inflammation; Oxidative
   stress; Hepatic steatosis
ID C-REACTIVE PROTEIN; NF-KAPPA-B; DENSITY-LIPOPROTEIN CHOLESTEROL; TYPE-2
   DIABETES-MELLITUS; METABOLIC SYNDROME; HEPATIC STEATOSIS; BROCCOLI
   SPROUTS; OXIDATIVE STRESS; GLYCEMIC CONTROL; ADIPOSE-TISSUE
AB The purpose of this work was to compare the influences of sulforaphane (SFN) to those of the standard insulin sensitizer pioglitazone (PIO) on high fructose diet (HFrD)-induced insulin resistance, dyslipidemia, hepatosteatosis, and vascular dysfunction in rats.
   Male Sprague Dawley rats (150-200 g) were fed on a standard diet (control) or a high fructose diet (HFrD, 60% w/w fructose) for 60 days. From day 16, two subgroups of HFrD-fed rats received either SFN (0.5 mg/kg/day, orally) or PIO (5 mg/kg/day, orally) along with HFrD until the end of the experiment.
   Fructose-fed rats showed significant decreases in food intake, body weight and feeding efficiency; effects that were not altered by either treatment. Data from insulin tolerance test (ITT), oral glucose tolerance test (OGTT), and HOMA-IR and HOMA-beta indices demonstrated impaired insulin sensitivity and glucose utilization in HFrD-fed rats.
   SFN and PIO treatments significantly reduced OGTT(AUC) (Glass's Delta values = 1.12 and 0.84, respectively), decreased ITTAUC (Glass's Delta values = 1.05 and 0.71, respectively), significantly diminished HOMA-IR index (by 55.6% and 77.6%, respectively), and increased HOMA-beta value (by 1.8 and 1.3 fold, respectively) compared to the HFrD rats. Moreover, SFN and PIO ameliorated hepatic oxidative stress and reduced serum levels of C-reactive protein and lactate dehydrogenase in HFrD-fed rats. Furthermore, SFN and PIO administrations improved insulin resistance-associated heaptosteatosis and enhanced vascular responsiveness to acetylcholine -induced relaxations. However, only SFN was able to enhance serum HDL-C levels in HFrD group.
   These finding suggests that SFN elicited insulin-sensitizing, hepatoprotective, and vasculoprotective effects in HFrD insulin-resistant rats that were comparable to those exerted by PIO.
C1 [Shawky, Noha M.; Shehatou, George S. G.; Suddek, Ghada M.; Gameil, Nariman M.] Mansoura Univ, Fac Pharm, Dept Pharmacol & Toxicol, Mansoura 35516, Egypt.
C3 Egyptian Knowledge Bank (EKB); Mansoura University
RP Shawky, NM (corresponding author), Mansoura Univ, Fac Pharm, Dept Pharmacol & Toxicol, Mansoura 35516, Egypt.
EM noha.shawki.elsayed@gmail.com
RI Suddek, Ghada/HPE-4718-2023; Shawky, noha/AAO-9722-2021; Shehatou,
   George/P-3123-2018
OI Suddek, Ghada/0000-0002-3283-9471; Shawky, Noha/0000-0003-4324-8586;
   Shehatou, George/0000-0001-5501-1004
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NR 87
TC 25
Z9 25
U1 0
U2 14
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1382-6689
EI 1872-7077
J9 ENVIRON TOXICOL PHAR
JI Environ. Toxicol. Pharmacol.
PD FEB
PY 2019
VL 66
BP 43
EP 54
DI 10.1016/j.etap.2018.12.008
PG 12
WC Environmental Sciences; Pharmacology & Pharmacy; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Pharmacology & Pharmacy; Toxicology
GA HL4QD
UT WOS:000458707300006
PM 30597379
DA 2025-06-11
ER

PT J
AU Kracmerová, J
   Czudková, E
   Koc, M
   Malisová, L
   Siklová, M
   Stich, V
   Rossmeislová, L
AF Kracmerova, Jana
   Czudkova, Eva
   Koc, Michal
   Malisova, Lucia
   Siklova, Michaela
   Stich, Vladimir
   Rossmeislova, Lenka
TI Postprandial inflammation is not associated with endoplasmic reticulum
   stress in peripheral blood mononuclear cells from healthy lean men
SO BRITISH JOURNAL OF NUTRITION
LA English
DT Article
DE Peripheral blood mononuclear cells; Ursodeoxycholic acid; Postprandial
   inflammation; Endoplasmic reticulum stress
ID ACTIVATING TRANSCRIPTION FACTOR-3; HIGH-FAT MEAL; ADIPOSE-TISSUE;
   URSODEOXYCHOLIC ACID; METABOLIC SYNDROME; EXPRESSION; OBESE; MONOCYTES;
   SECRETION; ADHESION
AB The consumption of lipids and simple sugars induces an inflammatory response whose exact molecular trigger remains elusive. The aims of the present study were to investigate (1) whether inflammation induced by a single high-energy, high-fat meal (HFM) is associated with endoplasmic reticulum stress (ERS) in peripheral blood mononuclear cells (PBMC) and (2) whether these inflammatory and ERS responses could be prevented by the chemical chaperone ursodeoxycholic acid (UDCA). A total of ten healthy lean men were recruited to a randomised, blind, cross-over trial. Subjects were given two doses of placebo (lactose) or UDCA before the consumption of a HFM (6151 kJ; 47.4% lipids). Blood was collected at baseline and 4 h after the HFM challenge. Cell populations and their activation were analysed using flow cytometry, and plasma levels of inflammatory cytokines were assessed by ELISA and Luminex technology. Gene expression levels of inflammatory and ERS markers were analysed in CD14(+) and CD14(-) PBMC using quantitative RT-PCR. The HFM induced an increase in the mRNA expression levels of pro-inflammatory cytokines (IL-1 beta, 2.1-fold; IL-8, 2.4-fold; TNF-alpha, 1.4-fold; monocyte chemoattractant protein 1, 2.1-fold) and a decrease in the expression levels of miR181 (0.8-fold) in CD14(+) monocytes. The HFM challenge did not up-regulate the expression of ERS markers (XBP1, HSPA5, EDEM1, DNAJC3 and ATF4) in either CD14(-) or CD14(-) cell populations, except for ATF3 (2.3-fold). The administration of UDCA before the consumption of the HFM did not alter the HFM-induced change in the expression levels of ERS or inflammatory markers. In conclusion, HFM-induced inflammation detectable on the level of gene expression in PBMC was not associated with the concomitant increase in the expression levels of ERS markers and could not be prevented by UDCA.
C1 [Kracmerova, Jana; Czudkova, Eva; Koc, Michal; Malisova, Lucia; Siklova, Michaela; Stich, Vladimir; Rossmeislova, Lenka] Charles Univ Prague, Fac Med 3, Dept Sport Med, Prague 10000 10, Czech Republic.
   [Kracmerova, Jana; Czudkova, Eva; Koc, Michal; Malisova, Lucia; Siklova, Michaela; Stich, Vladimir; Rossmeislova, Lenka] Charles Univ Prague, Fac Med 3, Franco Czech Lab Clin Res Obes, Prague 10000 10, Czech Republic.
C3 Charles University Prague; Charles University Prague
RP Rossmeislová, L (corresponding author), Charles Univ Prague, Fac Med 3, Dept Sport Med, Ruska 87, Prague 10000 10, Czech Republic.
EM lenka.rossmeislova@lf3.cuni.cz
RI Koc, Michal/D-1234-2014; Krauzova, Eva/T-1921-2017; Neubert,
   Jana/HNR-0780-2023; Siklova, Michaela/G-6939-2015; Rossmeislova,
   Lenka/D-1931-2013
OI Krauzova, Eva/0000-0003-2007-8414; Neubert, Jana/0000-0002-2159-7139;
   Siklova, Michaela/0000-0003-0489-1069; Rossmeislova,
   Lenka/0000-0002-7611-7585
FU Grant Agency of the Czech Republic [GACR 301/11/0748]; Ministry of
   Health [IGA NT 144 86]; Charles University [UNCE 204015]
FX The present study was supported by grant GACR 301/11/0748 of the Grant
   Agency of the Czech Republic, IGA NT 144 86 of the Ministry of Health
   and UNCE 204015 of Charles University. These funders had no role in the
   design, analysis or writing of this article.
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NR 45
TC 6
Z9 13
U1 0
U2 11
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1145
EI 1475-2662
J9 BRIT J NUTR
JI Br. J. Nutr.
PD AUG 28
PY 2014
VL 112
IS 4
BP 573
EP 582
DI 10.1017/S0007114514001093
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA AN4QD
UT WOS:000340571800011
PM 24870697
OA Bronze
DA 2025-06-11
ER

PT J
AU Bo, S
   Gambino, R
   Durazzo, M
   Guidi, S
   Tiozzo, E
   Ghione, F
   Gentile, L
   Cassader, M
   Pagano, GF
AF Bo, Simona
   Gambino, Roberto
   Durazzo, Marilena
   Guidi, Sabrina
   Tiozzo, Elisa
   Ghione, Federica
   Gentile, Luigi
   Cassader, Maurizio
   Pagano, Gian Franco
TI Associations between γ-glutamyl transferase, metabolic abnormalities and
   inflammation in healthy subjects from a population-based cohort: A
   possible implication for oxidative stress
SO WORLD JOURNAL OF GASTROENTEROLOGY
LA English
DT Article
DE Alanine aminotransferase; Aspartate aminotransferase; Body mass index;
   C-reactive protein; gamma-Glutamyl transferase; Metabolic syndrome;
   Nitrotyrosine
ID C-REACTIVE PROTEIN; ARTERY RISK DEVELOPMENT; FATTY LIVER-DISEASE;
   ALANINE AMINOTRANSFERASE; INSULIN-RESISTANCE; OBESE; NITROTYROSINE;
   HYPERTENSION; ELEVATION; PREDICTS
AB AIM: To examine the relationships between gamma-glutamyltransferase (GGT), alanine-aminotransferase (ALT), aspartate-aminotransferase (AST) and various metabolic parameters, C-reactive protein (CRP) and an oxidative stress marker (nitrotyrosine, NT) in subjects without any metabolic abnormalities from a population-based sample.
   METHODS: Two hundred and five subjects with normal body mass index (BMI), glucose tolerance, and without any metabolic abnormality were studied out of 1 339 subjects, without known liver diseases, alcohol abuse or use of hepatotoxic drugs, who are representative of the 45-64 aged population of Asti (north-western Italy).
   RESULTS: In all patients metabolic parameters and hs-CRP levels linearly increase from the lowest to the highest ALT and GGT tertiles, while in subjects without metabolic abnormalities, there is a significant association between fasting glucose, uric acid, waist circumference, hs-CRP, triglyceride values, and GGT levels. In these subjects, male sex, higher hs-CRP and glucose levels are associated with GGT levels in a multiple regression model, after adjustments for multiple confounders. In the same model, median NT levels are significantly associated with the increasing GGT tertile (beta = 1.06; 95% CI 0.67-1.45), but not with the AST and ALT tertiles. In a multiple regression model, after adjusting for age, sex, BMI, waist, smoking, and alcohol consumption, both NT (beta = 0.05; 95% CI 0.02-0.08) and hs-CRP levels (beta = 0.09; 95% CI 0.03-0.15) are significantly associated with fasting glycemia.
   CONCLUSION: GGT, an easy, universally standardized and available measurement, could represent an early marker of sub-clinical inflammation and oxidative stress in otherwise healthy individuals. Prospective studies are needed to establish if GGT could predict future diabetes in these subjects. (C) 2005 The WJG Press and Elsevier Inc. All rights reserved.
C1 [Bo, Simona; Gambino, Roberto; Durazzo, Marilena; Guidi, Sabrina; Tiozzo, Elisa; Ghione, Federica; Cassader, Maurizio; Pagano, Gian Franco] Univ Turin, Dept Internal Med, I-10126 Turin, Italy.
C3 University of Turin
RP Bo, S (corresponding author), Univ Turin, Dept Internal Med, Corso Dogliotti 14, I-10126 Turin, Italy.
EM sbo@molinette.piemonte.it
RI GAMBINO, Roberto/AAC-7517-2022; Bo, Simona/AAC-1110-2019
OI Bo, Simona/0000-0001-6862-8628; DURAZZO, Marilena/0000-0003-2450-5911
FU Progetto di Ricerca Sanitaria Finalizzata, Regione Piemonte
FX Supported by a grant: "Progetto di Ricerca Sanitaria Finalizzata,
   Regione Piemonte, 2003"
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NR 38
TC 71
Z9 75
U1 0
U2 4
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 7041 Koll Center Parkway, Suite 160, PLEASANTON, CA, UNITED STATES
SN 1007-9327
EI 2219-2840
J9 WORLD J GASTROENTERO
JI World J. Gastroenterol.
PD DEC 7
PY 2005
VL 11
IS 45
BP 7109
EP 7117
DI 10.3748/wjg.v11.i45.7109
PG 9
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA V20RQ
UT WOS:000208157500008
PM 16437656
OA Green Published, hybrid, Green Submitted
DA 2025-06-11
ER

PT J
AU Souza-Talarico, JN
   Suchecki, D
   Juster, RP
   Plusquellec, P
   Barbosa, F
   Bunscheit, V
   Marcouralcis, T
   de Matos, TM
   Lupien, SJ
AF Souza-Talarico, Juliana N.
   Suchecki, Deborah
   Juster, Robert-Paul
   Plusquellec, Pierrich
   Barbosa Junior, Fernando
   Bunscheit, Vinicius
   Marcouralcis, Tania
   de Matos, Tatiane Martins
   Lupien, Sonia J.
TI Lead exposure is related to hypercortisolemic profiles and allostatic
   load in Brazilian older adults
SO ENVIRONMENTAL RESEARCH
LA English
DT Article
DE Blood lead; cortisol; HPA axis; Allostatic load; Aging
ID MINI-MENTAL-STATE; BLOOD-PRESSURE; METABOLIC SYNDROME; BONE LEAD;
   LIFE-SPAN; STRESS; CORTISOL; MACARTHUR; RISK; AGE
AB Lead levels (Pb) have been linked to both hyper-and hypo-reactivity of hypothalamic-pituitary-adrenal axis (HPA) axis to acute stress in animals and humans. Similarly, allostatic load (AL), the 'wear and tear' of chronic stress, is associated with inadequate HPA axis activity. We examined whether Pb levels would be associated with altered diurnal cortisol profile, as a primary mediator of AL, during aging. Pb levels were measured from blood samples (BPb) of 126 Brazilian individuals (105 women), between 50 and 82 years old. Six neuroendocrine, metabolic, and anthropometric biomarkers were analyzed and values were transformed into an AL index using clinical reference cut-offs. Salivary samples were collected at home over 2 days at awakening, 30-min after waking, afternoon, and evening periods to determine cortisol levels. A multiple linear regression model showed a positive association between BPb as the independent continuous variable and cortisol awakening response (R-2=0.128; B=0.791; p=0.005) and overall cortisol concentration (R-2=0.266; B=0.889; p < 0.001) as the outcomes. Repeated measures ANOVA showed that individuals with high BPb levels showed higher cortisol at 30 min after awakening (p=0.003), and in the afternoon (p=0.002) than those with low BPb values. Regarding AL, regression model showed that BPb was positively associated with AL index (R-2=0.100; B=0.204; p=0.032). Correlation analyzes with individual biomarkers showed that BPb was positively correlated with HDL cholesterol (p=0.02) and negatively correlated with DHEA-S (p=0.049). These findings suggest that Pb exposure, even at levels below the reference blood lead level for adults recommended by the National Institute for Occupational Safety and Health and by the Center for Disease Control and Prevention, may contribute to AL and dysregulated cortisol functioning in older adults. Considering these findings were based on cross-sectional data future research is needed to confirm our exploratory results.
C1 [Souza-Talarico, Juliana N.; de Matos, Tatiane Martins] Univ Sao Paulo, Sch Nursing, Dept Med Surg Nursing, BR-05403000 Sao Paulo, Brazil.
   [Suchecki, Deborah] Univ Fed Sao Paulo, Dept Psychobiol, BR-04023062 Sao Paulo, Brazil.
   [Juster, Robert-Paul] Columbia Univ Med Ctr, Dept Psychiat, New York, NY 10032 USA.
   [Plusquellec, Pierrich; Lupien, Sonia J.] Univ Montreal, Ctr Studies Human Stress, Mental Hlth Univ Inst, Dept Psychiat, Montreal, PQ HIN 3V2, Canada.
   [Plusquellec, Pierrich] Univ Montreal, Sch Psychoeducat, Montreal, PQ JIK 2RI, Canada.
   [Barbosa Junior, Fernando] Sch Pharmaceut Sci Ribeirao Preto, Univ Sao Paulo, Dept Clin Chem & Toxicol, BR-14040903 Ribeirao Preto, Brazil.
   [Marcouralcis, Tania] Univ Sao Paulo, Sch Pharmaceut Sci, Dept Clin Chem & Toxicol, BR-05508000 Sao Paulo, Brazil.
C3 Universidade de Sao Paulo; Universidade Federal de Sao Paulo (UNIFESP);
   Columbia University; Universite de Montreal; Universite de Montreal;
   Universidade de Sao Paulo; Universidade de Sao Paulo
RP Souza-Talarico, JN (corresponding author), Univ Sao Paulo, Sch Nursing, Dept Med Surg Nursing, BR-05403000 Sao Paulo, Brazil.
EM junery@usp.br
RI Talarico, Juliana/ABA-8650-2020; Souza-Talarico, Juliana
   Nery/K-6133-2012; Marcourakis, Tania/D-6667-2012; Barbosa Jr,
   Fernando/C-6929-2012; Suchecki, Deborah/B-7654-2012
OI Souza-Talarico, Juliana Nery/0000-0001-8820-0725; Marcourakis,
   Tania/0000-0002-0076-5017; Juster, Robert Paul/0000-0003-4133-4042;
   Barbosa Jr, Fernando/0000-0002-2498-0619; Suchecki,
   Deborah/0000-0003-1697-8663
FU Sao Paulo Research Foundation (FAPESP) in Brazil [2009/13911-6]
FX This research study was supported by a grant from the Sao Paulo Research
   Foundation (FAPESP) for the financial support (#2009/13911-6) in Brazil,
   pilot project competition to Deborah Suchecki. The study was approved by
   the Ethic Committee of Universidade Federal de Sao Paulo (UNIFESP), Sao
   Paulo, Brazil (#0823/09) and all participants provided informed consent.
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NR 66
TC 21
Z9 26
U1 1
U2 20
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0013-9351
EI 1096-0953
J9 ENVIRON RES
JI Environ. Res.
PD APR
PY 2017
VL 154
BP 261
EP 268
DI 10.1016/j.envres.2017.01.012
PG 8
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA EM9FS
UT WOS:000395617600035
PM 28110240
DA 2025-06-11
ER

PT J
AU Naguib, YM
   Samaka, RM
   Rizk, MS
   Ameen, O
   Motawea, SM
AF Naguib, Yahya M.
   Samaka, Rehab M.
   Rizk, Mohamed S.
   Ameen, Omnia
   Motawea, Shaimaa M.
TI Countering adipose tissue dysfunction could underlie the superiority of
   telmisartan in the treatment of obesity-related hypertension
SO CARDIOVASCULAR DIABETOLOGY
LA English
DT Article
DE Obesity; Hypertension; Angiotensin receptor blockers; Telmisartan;
   Adipose tissue
ID NECROSIS-FACTOR-ALPHA; BODY-MASS INDEX; INSULIN-RESISTANCE;
   BLOOD-PRESSURE; CARDIOVASCULAR RISK; METABOLIC SYNDROME; RECEPTOR
   BLOCKERS; LEPTIN; KIDNEY; FAT
AB Background The prevalence of hypertension and obesity has increased significantly in recent decades. Hypertension and obesity often coexist, and both are associated with increased cardiovascular mortality. Obese hypertensive patients usually require special anti-hypertensive treatment strategy due to the increased risk of treatment resistance. Molecules that can target both obesity and hypertension underlying pathologies should get more attention. Herein, we evaluated the therapeutic effects of telmisartan, with special interest in visceral adipose tissue dysfunction, in obesity-related hypertension rat model. Methods Thirty male Wistar rats weighing 150-200 g were equally divided into: 1-Control group (fed normal laboratory diet for 24 weeks), 2-Diet-induced obesity group (DIO, fed high fat diet for 24 weeks), and 3-Diet-induced obesity treated with telmisartan group (DIO + Tel, fed high fat diet and received telmisartan for 24 weeks). At the end of the study, anthropometrical parameters were evaluated. Systolic blood pressure and heart rate were measured. Blood samples were collected for the measurement of serum lipids, adipokines, cardiac, renal, inflammatory, and oxidative stress biomarkers. Kidneys were removed and used for histopathological studies, and visceral adipose tissue was utilized for histopathological, immunohistochemical and RT-PCR studies. Results High fat diet resulted in obesity-related changes in anthropometrical parameters, elevation of blood pressure, increase in heart rate, higher serum levels of cardiac, inflammatory and kidney function biomarkers, with altered serum lipids, adipokines and oxidative stress markers. Morphological changes (H&E and PAS-stained sections) were noticed in kidneys and visceral adipose tissue. Immunohistochemistry and RT-PCR studies confirmed adipose tissue dysfunction and over-expression of inflammatory and oxidative stress proteins. Telmisartan countered obesity-induced alterations in cardiovascular, renal, and adipose tissue functions. Conclusion Adipose tissue dysfunction could be the core pathophysiology of obesity-related hypertension. Besides its anti-hypertensive effect, telmisartan had profound actions on visceral adipose tissue structure and function. Attention should be given to polymodal molecules targeting adipose tissue-related disorders.
C1 [Naguib, Yahya M.] Arabian Gulf Univ, Coll Med & Med Sci, Physiol Dept, Manama, Bahrain.
   [Naguib, Yahya M.; Ameen, Omnia; Motawea, Shaimaa M.] Menoufia Univ, Fac Med, Clin Physiol Dept, Menoufia, Egypt.
   [Samaka, Rehab M.] Menoufia Univ, Fac Med, Pathol Dept, Menoufia, Egypt.
   [Rizk, Mohamed S.] Menoufia Univ, Fac Med, Med Biochem & Mol Biol Dept, Menoufia, Egypt.
C3 Arabian Gulf University; Egyptian Knowledge Bank (EKB); Menofia
   University; Egyptian Knowledge Bank (EKB); Menofia University; Egyptian
   Knowledge Bank (EKB); Menofia University
RP Naguib, YM (corresponding author), Arabian Gulf Univ, Coll Med & Med Sci, Physiol Dept, Manama, Bahrain.
EM yahyamn@agu.edu.bh
RI Rizk, Mohamed/JTU-2235-2023; Naguib, Yahya/R-2949-2019
OI Naguib, Yahya/0000-0001-5851-7238
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NR 80
TC 11
Z9 11
U1 0
U2 13
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1475-2840
J9 CARDIOVASC DIABETOL
JI Cardiovasc. Diabetol.
PD MAR 24
PY 2021
VL 20
IS 1
AR 70
DI 10.1186/s12933-021-01259-w
PG 19
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism
GA RB9CX
UT WOS:000632403600001
PM 33761942
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Rauf, A
   Imran, M
   Orhan, IE
   Bawazeer, S
AF Rauf, Abdur
   Imran, Muhammad
   Orhan, Ilkay Erdogan
   Bawazeer, Saud
TI Health perspectives of a bioactive compound curcumin: A review
SO TRENDS IN FOOD SCIENCE & TECHNOLOGY
LA English
DT Review
DE Curcumin; Cancer insurgence; Antidiabetic; Antiobesity; Oxidative
   stress; Cardiovascular
ID INDUCED CELL-DEATH; OXIDATIVE STRESS; RAT MODEL; METABOLIC SYNDROME;
   INDUCED SENESCENCE; DRUG-DELIVERY; LIVER-INJURY; CANCER CELLS;
   DOUBLE-BLIND; MOUSE MODEL
AB Curcumin (1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione) is a is an important consituitents present in Curcuma longa L (turmeric) rhizome. It is also a lipophilic molecule that rapidly permeates cell membrane. Curcumin has been used as pharmacological traditional medicinal agent in Ayurvedic medicine for similar to 6000 years. Being chemopreventive agent, curcumin has been found to modulate multiple molecular pathways through several mechanisms, e.g. induction of apoptosis, inhibition survival signals, and prevention from reactive oxidative species (ROS). Curcumin significantly caused reduction in lung cancer stem cells markers (CD133, ALDHA1, CD44, Nanog, and Oct4) and the number of CD133-positive cells as well as efficiently decreased the tumorsphere formation, inhibited proliferation, and induced apoptotic cell death. It also suppressed the activation of both Wnt/beta-catenin and Sonic Hedgehog pathways. Curcumin has been also reported to diminish renal hypertrophy, reduce mesangial matrix expansion, and cause a lower level of albuminuria. It also inhibited the upregulated protein and mRNA expressions of collagen IV and fibronectin in the renal cortices as well as significantly reduced the mature interleukin-1 beta, cleaved caspase-1, and NLRP3 protein levels in the renal cortices of db/db mice as well as in HK-2 cells. It also ameliorated the defective insulin signalling pathway by upregulating insulin-like growth factor (IGF)-1R, IRS-2, PI3K, p-PI3K, Akt and p-Akt protein expression while downregulating IR and IRS-1. Besides, curcumin lowered the heart MDA and DNA fragmentation levels, increased concentration of SOD, catalase, and gluathione levels, decreased the percentage of TUNEL-positive cells and gamma H2AX protein expression, while it lowered the percentage (%) of capspase 3 positive cells and improved the percentage of Bcl-2 positive cells. The current review article presents effective role of curcumin against cancer, diabetes, oxidative stress, cardiovascular, obesity, and aging.
C1 [Rauf, Abdur] Univ Swabi, Dept Chem, Anbar 23561, Khyber Pakhtunkhwa, Pakistan.
   [Imran, Muhammad] Univ Lahore, Fac Allied Hlth Sci, Univ Inst Diet & Nutr Sci, Lahore, Pakistan.
   [Orhan, Ilkay Erdogan] Gazi Univ, Fac Pharm, Dept Pharmacognosy, TR-06330 Ankara, Turkey.
   [Bawazeer, Saud] Umm Al Qura Univ, Dept Pharmaceut Chem, Fac Pharm, POB 42, Mecca, Saudi Arabia.
C3 University of Lahore; Gazi University; Umm Al-Qura University
RP Rauf, A (corresponding author), Univ Swabi, Dept Chem, Anbar 23561, Khyber Pakhtunkhwa, Pakistan.; Imran, M (corresponding author), Univ Lahore, Fac Allied Hlth Sci, Univ Inst Diet & Nutr Sci, Lahore, Pakistan.
EM abdurrauf@uoswabl.edu.pk; mic_1661@yahoo.com
RI Imran, Muhammad/JEF-6364-2023; Rauf, Abdur/G-3304-2013; ORHAN, ILKAY
   ERDOGAN/H-6092-2011
OI ERDOGAN ORHAN, ILKAY/0000-0002-7379-5436; Rauf, Dr.
   Abdur/0000-0003-2429-5491
FU Deanship of Scientific Research at Umm Al-Qura University
   [15MED-3-2-0001]; Deanship of Scientific Research at Umm Al-Qura
   University
FX The authors would alike to thanks the Deanship of Scientific Research at
   Umm Al-Qura University for the incessant funding. This work was
   reinforced financially by the Deanship of Scientific Research at Umm
   Al-Qura University to Dr. Saud Bawazeer (Grant Code: 15MED-3-2-0001).
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NR 126
TC 87
Z9 100
U1 5
U2 111
PU ELSEVIER SCIENCE LONDON
PI LONDON
PA 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND
SN 0924-2244
EI 1879-3053
J9 TRENDS FOOD SCI TECH
JI Trends Food Sci. Technol.
PD APR
PY 2018
VL 74
BP 33
EP 45
DI 10.1016/j.tifs.2018.01.016
PG 13
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA GD8JJ
UT WOS:000430758400004
DA 2025-06-11
ER

PT J
AU Tomasdottir, MO
   Sigurdsson, JA
   Petursson, H
   Kirkengen, AL
   Krokstad, S
   McEwen, B
   Hetlevik, I
   Getz, L
AF Tomasdottir, Margret Olafia
   Sigurdsson, Johann Agust
   Petursson, Halfdan
   Kirkengen, Anna Luise
   Krokstad, Steinar
   McEwen, Bruce
   Hetlevik, Irene
   Getz, Linn
TI Self Reported Childhood Difficulties, Adult Multimorbidity and
   Allostatic Load. A Cross-Sectional Analysis of the Norwegian HUNT Study
SO PLOS ONE
LA English
DT Article
ID LEUKOCYTE TELOMERE LENGTH; HEALTH DISPARITIES; METABOLIC SYNDROME; TOXIC
   STRESS; LIFE STRESS; EXPERIENCES; ADVERSITY; DISEASE; ABUSE; WOMEN
AB Background
   Multimorbidity receives increasing scientific attention. So does the detrimental health impact of adverse childhood experiences (ACE). Aetiological pathways from ACE to complex disease burdens are under investigation. In this context, the concept of allostatic overload is relevant, denoting the link between chronic detrimental stress, widespread biological perturbations and disease development. This study aimed to explore associations between self-reported childhood quality, biological perturbations and multimorbidity in adulthood.
   Materials and Methods
   We included 37 612 participants, 30-69 years, from the Nord-Trondelag Health Study, HUNT3 (2006-8). Twenty one chronic diseases, twelve biological parameters associated with allostatic load and four behavioural factors were analysed. Participants were categorised according to the self-reported quality of their childhood, as reflected in one question, alternatives ranging from 'very good' to 'very difficult'. The association between childhood quality, behavioural patterns, allostatic load and multimorbidity was compared between groups.
   Results
   Overall, 85.4% of participants reported a 'good' or 'very good' childhood; 10.6% average, 3.3% 'difficult' and 0.8% 'very difficult'. Childhood difficulties were reported more often among women, smokers, individuals with sleep problems, less physical activity and lower education. In total, 44.8% of participants with a very good childhood had multimorbidity compared to 77.1% of those with a very difficult childhood (Odds ratio: 5.08; 95% CI: 3.63-7.11). Prevalences of individual diseases also differed significantly according to childhood quality; all but two ( cancer and hypertension) showed a significantly higher prevalence (p < 0.05) as childhood was categorised as more difficult. Eight of the 12 allostatic parameters differed significantly between childhood groups.
   Conclusions
   We found a general, graded association between self-reported childhood difficulties on the one hand and multimorbidity, individual disease burden and biological perturbations on the other. The finding is in accordance with previous research which conceptualises allostatic overload as an important route by which childhood adversities become biologically embodied.
C1 [Tomasdottir, Margret Olafia; Sigurdsson, Johann Agust] Univ Iceland, Dept Family Med, Reykjavik, Iceland.
   [Tomasdottir, Margret Olafia; Sigurdsson, Johann Agust] Primary Hlth Care Capital Area, Reykjavik, Iceland.
   [Tomasdottir, Margret Olafia; Sigurdsson, Johann Agust; Petursson, Halfdan; Kirkengen, Anna Luise; Hetlevik, Irene; Getz, Linn] Norwegian Univ Sci & Technol NTNU, Dept Publ Hlth & Gen Practice, Gen Practice Res Unit, Trondheim, Norway.
   [Kirkengen, Anna Luise] UiT Arct Univ, Dept Gen Practice, Tromso, Norway.
   [Krokstad, Steinar] Norwegian Univ Sci & Technol NTNU, HUNT Res Ctr, Dept Publ Hlth & Gen Practice, Levanger, Norway.
   [McEwen, Bruce] Rockefeller Univ, Neuroendocrinol Lab, New York, NY 10021 USA.
C3 University of Iceland; Norwegian University of Science & Technology
   (NTNU); UiT The Arctic University of Tromso; Norwegian University of
   Science & Technology (NTNU); Rockefeller University
RP Tomasdottir, MO (corresponding author), Univ Iceland, Dept Family Med, Reykjavik, Iceland.
EM margretolafia@gmail.com
RI Sigurdsson, Johann/NBY-2452-2025; McEwen, Bruce/Z-1630-2019
OI Tomasdottir, Margret/0000-0003-4675-5532; Krokstad,
   Steinar/0000-0002-2932-6675
FU Norwegian Ministry of Health; Norwegian University of Science and
   Technology; Norwegian Research Council (the FUGE program);
   Nord-Trondelag County Council; Norwegian Institute of Public Health;
   Icelandic College of Family Physicians; Central Norway Regional Health
   Authority
FX The HUNT3 Survey was mainly funded by the Norwegian Ministry of Health,
   the Norwegian University of Science and Technology, the Norwegian
   Research Council (the FUGE program), Central Norway Regional Health
   Authority, the Nord-Trondelag County Council and the Norwegian Institute
   of Public Health. The present analysis received support from the
   Research Fund of the Icelandic College of Family Physicians. The funders
   had no role in study design, data collection and analysis, decision to
   publish, or preparation of the manuscript.
CR ACE, ADV CHILDH EXP STUD
   [Anonymous], THE WORLD HEALTH REP
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NR 90
TC 91
Z9 99
U1 0
U2 23
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JUN 18
PY 2015
VL 10
IS 6
AR e0130591
DI 10.1371/journal.pone.0130591
PG 16
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Science & Technology - Other Topics
GA CK9NT
UT WOS:000356567500118
PM 26086816
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Nawrocka-Rutkowska, J
   Szydlowska, I
   Jakubowska, K
   Olszewska, M
   Chlubek, D
   Ryl, A
   Szczuko, M
   Starczewski, A
AF Nawrocka-Rutkowska, Jolanta
   Szydlowska, Iwona
   Jakubowska, Katarzyna
   Olszewska, Maria
   Chlubek, Dariusz
   Ryl, Aleksandra
   Szczuko, Malgorzata
   Starczewski, Andrzej
TI Assessment of the Parameters of Oxidative Stress Depending on the
   Metabolic and Anthropometric Status Indicators in Women with PCOS
SO LIFE-BASEL
LA English
DT Article
DE PCOS; oxidative stress; insulin resistance; glutathione peroxidase
   (GPx); catalase (CAT); superoxide dismutase (SOD); malonodialdehyde
   (MDA)
ID POLYCYSTIC-OVARY-SYNDROME; INSULIN-RESISTANCE; CATALASE DEFICIENCY;
   FREE-RADICALS; RISK; OBESITY; HYPERANDROGENISM; HYPERINSULINEMIA;
   MALONDIALDEHYDE; DYSFUNCTION
AB Polycystic ovary syndrome (PCOS) is one of the most common endocrinopathies in females of reproductive age. In women with PCOS, metabolic disorders such as insulin resistance (IR), hyperinsulinemia, obesity, diabetes mellitus, and other elements of metabolic syndrome are likely to occur. Studies have shown an increase in the concentration and activity of oxidative stress (OS) markers in patients with PCOS, compared to that in unaffected women. The aim of this study was to evaluate the parameters of OS in PCOS and their activity in relation to women without menstrual disorders with a normal body weight. Then, we compared malonodialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx), including overweight and obesity, hyperandrogenemia, and IR in the PCOS group. The study included 35 women aged 18-46, hospitalized for menstrual disorders in the form of infrequent menstruation. In 26 women, PCOS was diagnosed on the basis of the Rotterdam Criteria; these patients qualified for the study group. The control group (n = 21) consisted of patients without menstrual disorders and without PCOS in an ultrasound examination. Patients were diagnosed between the 2nd and 5th day of the cycle. The parameters of OS were analyzed and compared with the anthropometric parameters and the lipid profile of the patients. Enzymatic activity of GPx, CAT, SOD, and MDA levels was determined in both groups. MDA levels and CAT activity differed significantly between the groups. There was a decrease in MDA levels in the IR group and the involvement of GPx in the excess weight and obesity and IR group accompanied by an increase in hip circumference. It therefore seems that IR may be the main risk factor to exposure to OS in patients with PCOS, independent from obesity. In addition, GPx is involved in every step in the development of the pathological condition in PCOS.
C1 [Nawrocka-Rutkowska, Jolanta; Szydlowska, Iwona; Starczewski, Andrzej] Pomeranian Med Univ, Dept Gynecol Endocrinol & Gynecol Oncol, PL-71252 Szczecin, Poland.
   [Jakubowska, Katarzyna; Olszewska, Maria; Chlubek, Dariusz] Pomeranian Med Univ, Dept Biochem & Med Chem, PL-70111 Szczecin, Poland.
   [Ryl, Aleksandra] Pomeranian Med Univ, Dept Med Rehabil & Clin Physiotherapy, PL-71210 Szczecin, Poland.
   [Szczuko, Malgorzata] Pomeranian Med Univ, Dept Human Nutr & Metabol, PL-71460 Szczecin, Poland.
C3 Pomeranian Medical University; Pomeranian Medical University; Pomeranian
   Medical University; Pomeranian Medical University
RP Nawrocka-Rutkowska, J (corresponding author), Pomeranian Med Univ, Dept Gynecol Endocrinol & Gynecol Oncol, PL-71252 Szczecin, Poland.
EM Jolanta.nawrocka.rutkowska@pum.edu.pl; iwona.szydlowska@pum.edu.pl;
   jakubkas@pum.edu.pl; marolsz@pum.edu.pl; dchlubek@pum.edu.pl;
   aleksandra.ryl@pum.edu.pl; malgorzata.szczuko@pum.edu.pl;
   andrzejstarcz@o2.pl
RI Jakubowska, Katarzyna/B-2611-2016; Olszewska, Maria/N-7170-2014;
   Chlubek, Dariusz/J-6310-2014; Szydłowska, Iwona/AAA-6713-2022; Szczuko,
   Malgorzata/A-9501-2015; Ryl, Aleksandra/L-6760-2015
OI Szczuko, Malgorzata/0000-0001-9808-0624; Chlubek,
   Dariusz/0000-0003-4497-4395; Ryl, Aleksandra/0000-0002-5954-4489;
   Nawrocka-Rutkowska, Jolanta/0000-0002-1631-152X; Szydlowska,
   Iwona/0000-0003-1518-8838
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NR 60
TC 12
Z9 12
U1 0
U2 7
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2075-1729
J9 LIFE-BASEL
JI Life-Basel
PD FEB
PY 2022
VL 12
IS 2
AR 225
DI 10.3390/life12020225
PG 13
WC Biology; Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics; Microbiology
GA ZK2BC
UT WOS:000762798200001
PM 35207512
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Dong, XL
   Li, CM
   Cao, SS
   Zhou, LP
   Wong, MS
AF Dong, Xiao-Li
   Li, Chun-Mei
   Cao, Si-Si
   Zhou, Li-Ping
   Wong, Man-Sau
TI A High-Saturated-Fat, High-Sucrose Diet Aggravates Bone Loss in
   ovariectomized Female Rats
SO JOURNAL OF NUTRITION
LA English
DT Article
DE high-saturated-fat diet; high-sucrose diet; estrogen deficiency; bone
   loss; oxidative stress; Pparg
ID FRUCTUS-LIGUSTRI-LUCIDI; BODY-MASS INDEX; OXIDATIVE STRESS;
   INSULIN-RESISTANCE; MINERAL DENSITY; GENE-EXPRESSION; ER-ALPHA; MICE;
   CELLS; HYPERLIPIDEMIA
AB Background: Estrogen deficiency in women and high-saturated fat, high-sucrose (HFS) diets have both been recognized as risk factors for metabolic syndrome. Studies on the combined actions of these 2 detrimental factors on the bone in females are limited.
   Objective: We sought to determine the interactive actions of estrogen deficiency and an HFS diet on bone properties and to investigate the underlying mechanisms.
   Methods: Six-month-old Sprague Dawley sham or ovariectomized (OVX) rats were pair fed the same amount of either a low-saturated-fat, low-sucrose (LFS) diet (13% fat calories; 15% sucrose calories) or an HFS diet (42% fat calories; 30% sucrose calories) for 12 wk. Blood, liver, and bone were collected for correspondent parameters measurement.
   Results: Ovariectomy decreased bone mineral density in the tibia head (TH) by 62% and the femoral end (FE) by 49% (P < 0.0001). The HFS diet aggravated bone loss in OVX rats by an additional 41% in the TH and 37% in the FE (P < 0.05). Bone loss in the HFS-OVX rats was accompanied by increased urinary deoxypyridinoline concentrations by 28% (P < 0.05). The HFS diet induced cathepsin K by 145% but reduced osteoprotegerin mRNA expression at the FE of the HFS-sham rats by 71 % (P < 0.05). Ovariectomy significantly increased peroxisome proliferator-activated receptor gamma mRNA expression by 136% and 170% at the FE of the LFS- and HFS-OVX rats, respectively (P < 0.05). The HFS diet aggravated ovariectomy-induced lipid deposition and oxidative stress (OS) in rat livers (P < 0.05). Trabecular bone mineral density at the FE was negatively correlated with rat liver malondialdehyde concentrations (R-2 = 0.39; P < 0.01).
   Conclusions: The detrimental actions of the HES diet and ovariectomy on bone properties in rats occurred mainly in cancellous bones and were characterized by a high degree of bone resorption and alterations in OS.
C1 [Dong, Xiao-Li; Cao, Si-Si; Zhou, Li-Ping; Wong, Man-Sau] Shenzhen Key Lab Food Biol Safety Control, Shenzhen, Peoples R China.
   [Dong, Xiao-Li; Cao, Si-Si; Zhou, Li-Ping; Wong, Man-Sau] Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Kowloon, Hong Kong, Peoples R China.
   [Dong, Xiao-Li; Li, Chun-Mei; Wong, Man-Sau] S China Univ Technol, Shenzhen State Key Lab Chinese Med & Mol Pharmaco, Guangzhou 510641, Guangdong, Peoples R China.
   [Li, Chun-Mei] S China Univ Technol, Coll Light Ind & Food, Guangzhou 510641, Guangdong, Peoples R China.
   [Li, Chun-Mei] Guangdong Pharmaceut Coll, Dept Biochem & Mol Biol, Guangzhou, Guangdong, Peoples R China.
C3 Hong Kong Polytechnic University; South China University of Technology;
   South China University of Technology; Guangdong Pharmaceutical
   University
RP Wong, MS (corresponding author), Shenzhen Key Lab Food Biol Safety Control, Shenzhen, Peoples R China.; Wong, MS (corresponding author), Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Kowloon, Hong Kong, Peoples R China.; Wong, MS (corresponding author), S China Univ Technol, Shenzhen State Key Lab Chinese Med & Mol Pharmaco, Guangzhou 510641, Guangdong, Peoples R China.
EM bcmswong@polyu.edu.hk
RI Cao, Sisi/ADV-0612-2022; Wong, Man Sau/F-2059-2015
OI Wong, Man Sau/0000-0002-0729-8618; DONG, XIAOLI/0000-0002-7372-0450;
   Cao, Sisi/0000-0002-7413-295X; Zhou, Liping/0000-0002-9941-7812
FU Hong Kong Polytechnic University Central Research Fund [GYM-47, GUC17];
   Shenzhen Key Laboratory Program [ZDSY20140509142430241]; Shenzhen Key
   Laboratory Advancement Program [CXB201104220020A]; Shenzhen Basic
   Research Program [JCYJ20140819153305697, JCYJ20140819153305696];
   National Natural Science Foundation of China [81220108028]; National
   Major Scientific and Program of Introducing Talents of Discipline to
   Universities [B13038]
FX Supported by the Hong Kong Polytechnic University Central Research Fund
   (GYM-47 and GUC17); Shenzhen Key Laboratory Program (project code
   ZDSY20140509142430241); Shenzhen Key Laboratory Advancement Program
   (CXB201104220020A); Shenzhen Basic Research Program
   (JCYJ20140819153305697 and JCYJ20140819153305696); National Natural
   Science Foundation of China (81220108028); and the National Major
   Scientific and Program of Introducing Talents of Discipline to
   Universities (B13038).
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NR 37
TC 16
Z9 19
U1 0
U2 11
PU AMER SOC NUTRITION-ASN
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-3166
EI 1541-6100
J9 J NUTR
JI J. Nutr.
PD JUN
PY 2016
VL 146
IS 6
BP 1172
EP 1179
DI 10.3945/jn.115.225474
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA DN4RI
UT WOS:000377054500004
PM 27099231
OA Bronze
DA 2025-06-11
ER

PT J
AU Morvaridzadeh, M
   Sadeghi, E
   Agah, S
   Fazelian, S
   Rahimlou, M
   Kern, FG
   Heshmati, S
   Omidi, A
   Persad, E
   Heshmati, J
AF Morvaridzadeh, Mojgan
   Sadeghi, Ehsan
   Agah, Shahram
   Fazelian, Siavash
   Rahimlou, Mehran
   Kern, Ferdinand Georg
   Heshmati, Shilan
   Omidi, Amirhosein
   Persad, Emma
   Heshmati, Javad
TI Effect of ginger (Zingiber officinale) supplementation on
   oxidative stress parameters: A systematic review and meta-analysis
SO JOURNAL OF FOOD BIOCHEMISTRY
LA English
DT Review
DE ginger; glutathione peroxidase; malondialdehyde; oxidative stress; total
   antioxidant capacity
ID FATTY LIVER-DISEASE; METABOLIC SYNDROME; ANTIOXIDANT CAPACITY;
   LIPID-PEROXIDATION; DIABETES-MELLITUS; DOUBLE-BLIND; EXTRACT; PLACEBO;
   ROSCOE; MALONDIALDEHYDE
AB A wide variety of antioxidant properties are attributed to ginger (Zingiber officinale) and several randomized controlled trials (RCTs) have investigated the effect of ginger intake on major oxidative stress (OS) parameters. We conducted a systematic review and meta-analysis to evaluate the effects of using ginger to improve OS levels. Medline, Scopus, ISI Web of Science, EMBASE, and the Cochrane Central Register of Controlled Trials were systematically searched up until March 2020 to gather RCTs that evaluated the impact of ginger intake on the levels and activity of OS parameters in adult subjects. Means and standard deviations for relevant OS variables were extracted and evaluated to assess the quality of the trials based on the Cochrane risk-of-bias tool for randomized trials. The gathered data were pooled and expressed as standardized mean difference (SMD) with 95% Confidence Intervals (95% CI). Twelve trials were included in this review. Ginger intake was shown to significantly increase glutathione peroxidase (GPx) activity (SMD: 1.64; 95% CI: 0.43, 2.85; I-2 = 86.8%) and total antioxidant capacity (TAC) (SMD: 0.40; 95% CI: 0.06, 0.73; I-2 = 42.8%) and significantly decrease malondialdehyde (MDA) levels (SMD: -0.69; 95% CI: -1.26, -0.12; I-2 = 85.8%) compared to control groups. Ginger supplementation also non-significantly associated with an increase in CAT activity (SMD: 1.09; 95% CI: -0.07, 2.25; I-2 = 87.6%). This systematic review and meta-analysis presents convincing evidence supporting the efficacy of ginger supplementation on improving OS levels.
   Practical implications: In health sciences, OS, due to its pivotal role in the pathophysiology of several chronic diseases, is a subject with a long history. Recent research strives for a safe, ideal, and effective antioxidant. Ginger is herbal medicine, which has been widely used in traditional and complementary medicine. Proving the antioxidant effect and potential benefit of ginger has positive clinical implications for the application of this practical herb.
C1 [Morvaridzadeh, Mojgan; Heshmati, Shilan; Omidi, Amirhosein; Heshmati, Javad] Kermanshah Univ Med Sci, Sch Nutr Sci & Food Technol, Dept Nutr Sci, Kermanshah, Iran.
   [Agah, Shahram] Iran Univ Med Sci, Colorectal Res Ctr, Tehran, Iran.
   [Fazelian, Siavash] Shahrekord Univ Med Sci, Kashani Hosp, Clin Dev & Res Unit, Shahrekord, Iran.
   [Rahimlou, Mehran] Ahvaz Jundishapur Univ Med Sci, Fac Paramed, Nutr Dept, Ahvaz, Iran.
   [Sadeghi, Ehsan] Kermanshah Univ Med Sci, Res Ctr Environm Determinants Hlth RCEDH, Res Inst Hlth, Kermanshah, Iran.
   [Persad, Emma] Danube Univ Krems, Dept Evidence Based Med & Evaluat, Krems, Austria.
C3 Kermanshah University of Medical Sciences; Iran University of Medical
   Sciences; Shahrekord University Medical Sciences; Ahvaz Jundishapur
   University of Medical Sciences (AJUMS); Kermanshah University of Medical
   Sciences; Danube University Krems
RP Omidi, A; Heshmati, J (corresponding author), Kermanshah Univ Med Sci, Sch Nutr Sci & Food Technol, Dept Nutr Sci, Fac Nutr Sci & Food Technol, Isar Sq,Next Farabi Hosp, Kermanshah 6715847141, Iran.
EM amirhosein.omidi@gmail.com; Javad.Heshmati@gmail.com
RI Heshmati, Shilan/KWU-8586-2024; heshmati, javad/H-6812-2019; sadeghi,
   ehsan/AGR-8484-2022; Rahimlou, Mehran/AAL-4902-2021; Agah,
   Shahram/Y-5817-2018; Morvaridzadeh, Mojgan/GLU-6418-2022
OI Persad, Emma/0000-0003-2719-3685; Rahimlou, Mehran/0000-0002-7861-8287
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NR 61
TC 30
Z9 30
U1 0
U2 13
PU WILEY-HINDAWI
PI LONDON
PA ADAM HOUSE, 3RD FL, 1 FITZROY SQ, LONDON, WIT 5HE, ENGLAND
SN 0145-8884
EI 1745-4514
J9 J FOOD BIOCHEM
JI J. Food Biochem.
PD FEB
PY 2021
VL 45
IS 2
AR e13612
DI 10.1111/jfbc.13612
EA JAN 2021
PG 14
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA QL9IC
UT WOS:000608171800001
PM 33458848
OA gold
DA 2025-06-11
ER

PT J
AU Ghorban, K
   Shanaki, M
   Mobarra, N
   Azad, M
   Asadi, J
   Pakzad, R
   Ehteram, H
AF Ghorban, Khodayar
   Shanaki, Mehrnoosh
   Mobarra, Naser
   Azad, Mehdi
   Asadi, Jahanbakhsh
   Pakzad, Reza
   Ehteram, Hassan
TI Apolipoproteins A1, B, and other prognostic biochemical cardiovascular
   risk factors in patients with beta-thalassemia major
SO HEMATOLOGY
LA English
DT Article
DE Apolipoprotein; Beta-thalassemia major; Cardiovascular disease;
   Oxidative stress
ID C-REACTIVE PROTEIN; PROOXIDANT-ANTIOXIDANT BALANCE;
   CORONARY-HEART-DISEASE; PLASMA HOMOCYSTEINE; APOB/APOA1 RATIO; METABOLIC
   SYNDROME; VASCULAR-DISEASE; EVENTS; LIPOPROTEINS; PREDICTION
AB Objectives: The occurrence of cardiac iron deposition is one of the late effect of iron over load which causes cardiovascular disease (CVD) in patients who are affected by beta-thalassemia major. Evaluation of some cardiovascular risk factors plays a crucial role in prediction and prevention of CVD.
   Subjects and methods: This study consisted of 70 young adult subjects with beta-thalassemia major (beta-TM) (aged <30 years) and 71 age-and sex-matched healthy subjects as control group in the range of 20-30 years. Hematological and biochemical laboratory parameters including apolipoprotein (Apo)A1 and ApoB, oxidative stress biomarker pro-oxidant-antioxidant balance (PAB), homocysteine, serum high-sensitivity C-reactive protein (hs-CRP), and lipid profile were evaluated.
   Results: ApoA1, ApoB, lipid profiles, and homocysteine were significantly decreased in patients group (P < 0.001); however, very low-density lipoprotein and also mean corpuscular hemoglobin concentration (P > 0.05) were different. Some elements included ferritin (P < 0.001), PAB (P < 0.001), and ApoB/apoA1 ratio (P < 0.05) statistically increased in patients, whereas hs-CRP (P > 0.05) was not significantly different in study groups. Exception of high-density lipoprotein (P > 0.05), other lipid profiles, and apoB had a negative meaningful correlation with PAB (P < 0.05). Likewise, apoA1, apoB, apoB/A1 ratio with apoB and homocysteine showed a strong correlation (P < 0.05). We did not find a slight correlation between apoB/A1 ratio in the company of oxidative stress marker PAB (r = -0.366; P = 0.086). We found a statistical correlation between apoB/A1 and homocysteine (P < 0.05).
   Discussion: Higher level of some risk factors like PAB values, apoB/A1 ratio concentration, and lipid profiles is able to involve in the prognostic pathological consequences in patients with beta-thalassemia major. Even so, they contribute toward the gradual development of CVD.
C1 [Ghorban, Khodayar; Mobarra, Naser] AJA Univ Med Sci, Sch Med, Dept Immunol, Tehran, Iran.
   [Shanaki, Mehrnoosh] Shahid Beheshti Univ Med Sci, Sch Allied Med Sci, Dept Lab Med, Tehran, Iran.
   [Mobarra, Naser; Asadi, Jahanbakhsh] Golestan Univ Med Sci, Sch Med, Dept Biochem, Metab Disorders Res Ctr, Gorgan, Iran.
   [Azad, Mehdi] Qazvin Univ Med Sci, Fac Allied Med, Dept Med Lab Sci, Qazvin, Iran.
   [Pakzad, Reza] Univ Tehran Med Sci, Sch Publ Hlth, Dept Epidemiol, Tehran, Iran.
   [Pakzad, Reza] Univ Tehran Med Sci, Sch Publ Hlth, Dept Biostat, Tehran, Iran.
   [Ehteram, Hassan] Kashan Univ Med Sci, Sch Med, Dept Pathol, Kashan 9166655641, Iran.
   [Mobarra, Naser] Univ Tehran Med Sci, Students Sci Res Ctr, Tehran, Iran.
C3 Shahid Beheshti University Medical Sciences; Golestan University of
   Medical Sciences; Qazvin University of Medical Sciences (QUMS); Tehran
   University of Medical Sciences; Tehran University of Medical Sciences;
   Tehran University of Medical Sciences
RP Ehteram, H (corresponding author), Kashan Univ Med Sci, Sch Med, Dept Pathol, Kashan 9166655641, Iran.
EM h_ehteram@yahoo.com
RI Azad, Mehdi/K-9940-2017; Pakzad, Reza/X-7386-2018; Asadi,
   Jahanbakhsh/G-4096-2017
OI Shanaki, Mehrnoosh/0000-0002-2684-1014; Pakzad,
   Reza/0000-0001-8133-3664; Asadi, Jahanbakhsh/0000-0002-7068-2970; Asadi,
   Jahanbakhsh/0000-0001-8930-7647; Azad, Mehdi/0000-0002-5818-213X;
   ghorban, khodayar/0000-0003-3526-5597
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NR 48
TC 19
Z9 19
U1 0
U2 4
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1024-5332
EI 1607-8454
J9 HEMATOLOGY
JI Hematology
PY 2016
VL 21
IS 2
BP 113
EP 120
DI 10.1179/1607845415Y.0000000016
PG 8
WC Hematology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Hematology
GA DM8FI
UT WOS:000376596400007
PM 25913481
DA 2025-06-11
ER

PT J
AU Khamis, MM
   Moselhy, SS
   Rihan, S
AF Khamis, Marwa Maher
   Moselhy, Said Salama
   Rihan, Shaimaa
TI Role of trans-resveratrol in ameliorating biochemical and
   molecular alterations in obese rats induced by a high fructose/fat diet
SO SCIENTIFIC REPORTS
LA English
DT Article
DE trans-resveratrol; SIRT-1; PGC-1 alpha; Cyto-c; GLUT-4;
   Rats
ID INDUCED INSULIN-RESISTANCE; PANCREATIC BETA-CELL; HIGH-FAT;
   SKELETAL-MUSCLE; METABOLIC SYNDROME; GLUCOSE-TRANSPORT; OXIDATIVE
   STRESS; COACTIVATOR; SIRT1; MICE
AB We evaluated the effect of trans-resveratrol (RSV) in ameliorating biochemical and molecular alterations in obese Wister male rats fed on high-fat/high-fructose-fed. Male Wister rats were divided into eight groups and fed with either a standard diet (control), high fructose (HF), high fat (HFAT), or a high- fructose high- fat (HF/HFAT) diet and supplemented with RSV (30 mg/kg/day) for 4 weeks. The food intake, body weight, glycemic parameters, lipid profile, oxidative stress were assessed. SIRT1 gene expression, PGC-1 alpha, cyto-c and GLUT-4 were evaluated by qRT-PCR in adipose tissue of normal and obese rats. The body weight gain, serum fasting glucose, insulin, and HOMA-IR values were significantly higher in the HF and HF/HFAT groups than in the HFAT and control groups. Hyperlipidemia was observed in high calorie diets fed rats compared to control group. The levels of total cholesterol, triglycerides and LDL-c were significantly elevated while HDL- c was significantly decreased in HF & HF/HFAT groups compared to HFAT group. The levels of serum malondialdhyde (MDA) and superoxide dismutase (SOD) activity in adipose tissue were elevated in all groups compared to control group, particularly in the groups that were kept on a high fructose diets (HF, HF/HFAT). SIRT-1, PGC-1 alpha, Cyto-c, and GLUT-4 genes levels were significantly down regulated in HF, HFAT & HF/HFAT groups compared to control group. Supplementation of T-RSV restored the alteration in carbohydrates-lipid metabolism as well as oxidative stress and upregulation of SIRT-1, PGC-1 alpha, Cyto-c, and GLUT-4 genes. RSV is a promising treatment in the management of pathologic consequences of obesity from high-calorie diet consumption via molecular alteration of target genes.
C1 [Khamis, Marwa Maher; Moselhy, Said Salama; Rihan, Shaimaa] Ain Shams Univ, Fac Sci, Biochem Dept, Cairo, Egypt.
C3 Egyptian Knowledge Bank (EKB); Ain Shams University
RP Moselhy, SS (corresponding author), Ain Shams Univ, Fac Sci, Biochem Dept, Cairo, Egypt.
EM said_moselhy@sci.asu.edu.eg
RI Moselhy, Said/I-1446-2012
FU Science, Technology & Innovation Funding Authority (STDF); Egyptian
   Knowledge Bank (EKB)
FX Open access funding provided by The Science, Technology & Innovation
   Funding Authority (STDF) in cooperation with The Egyptian Knowledge Bank
   (EKB)
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NR 82
TC 0
Z9 0
U1 1
U2 1
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD MAR 6
PY 2025
VL 15
IS 1
AR 7879
DI 10.1038/s41598-025-91027-7
PG 13
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA Z6B0Z
UT WOS:001439724700034
PM 40050385
OA Green Accepted, gold
DA 2025-06-11
ER

PT J
AU Kali, MSK
   Khan, MRI
   Barman, RK
   Hossain, MF
   Wahed, MII
AF Kali, Most. Sumaiya Khatun
   Khan, Md. Rafiqul Islam
   Barman, Ranjan Kumar
   Hossain, Md. Farhad
   Wahed, Mir Imam Ibne
TI Cilnidipine and magnesium sulfate supplement ameliorates hyperglycemia,
   dyslipidemia and inhibits oxidative-stress in fructose-induced diabetic
   rats
SO HELIYON
LA English
DT Article
DE Novel calcium channel blocker; Cilnidipine; Fructose-diabetes; Lipid
   profile; Magnesium; Antioxidant activity
ID CALCIUM-CHANNEL BLOCKER; METABOLIC SYNDROME; BLOOD-PRESSURE;
   ANTIHYPERTENSIVE DRUGS; HYPERTENSIVE PATIENTS; INSULIN; ALBUMIN;
   GLUCOSE; SYSTEM; PATHOPHYSIOLOGY
AB The study was designed to evaluate the safety and efficacy of cilnidipine (CLN) and Mg-supplementation in fructose-induced diabetic rats. Diabetes was induced into male Wister rats by feeding fructose (10% solution) in drinking water for 8 weeks. Diabetic rats were subjected for the oral administration of CLN1 (1 mg/kg/day) and CLN10 (10 mg/kg/day), and/or methyl cellulose (0.5%) as vehicle for 28 days. After 14 days of CLN treatment, MgSO4 (1%) was added to CLN1 and CLN10 groups for another 14 days. Age-matched healthy rats were used as normal control. After 28 days body weights were measured and organ weight to body ratio was calculated. Serum samples were analysed for fasting blood sugar (FBS), glycosylated hemoglobin (HbA1c), uric acid, lipid profiles, tri-iodothyronine (T-3) and thyroid stimulating hormone (TSH), serum glutamic pyruvic transaminase (SGPT), serum glutamic oxaloacetic transaminase (SGOT), creatine phosphokinase myocardial-band (CK-MB), creatinine, albumin, electrolytes. Oral glucose tolerance tests (OGTT), liver histopathology and in-vivo antioxidant activities were also performed. The survival rate in diabetic rats was 100% after the oral administration of CLN, Mgsupplement and/or vehicle. A significant reduction in FBS levels and improvement in OGTT were observed in CLN10, CLN1+Mg and CLN10 + Mg groups after 28 days. Further, the treatment ameliorated serum lipid profile, uric acid, and albumin levels. The groups CLN10 and CLN10 + Mg improved HbA1c, liver glycogen, creatinine, T-3, TSH levels and electrolytes in diabetic rats. Moreover, liver from CLN10 and CLN10 thorn Mg groups showed preservation of cellular architecture as evidenced by attenuation of inflammatory markers SGPT, SGOT and CK- MB; and the levels of superoxide dismutase (SOD), catalase (CAT), glutathione, malondialdehyde (MDA), markers of oxidative stress were significantly improved. CLN exerted prominent effects in the amelioration of hyperglycemia, dyslipidemia and reduced hepatic inflammation; and Mg-supplementation might have some beneficial effects on diabetic complications and oxidative stress in fructose-induced diabetic rats.
C1 [Kali, Most. Sumaiya Khatun; Khan, Md. Rafiqul Islam; Barman, Ranjan Kumar; Wahed, Mir Imam Ibne] Univ Rajshahi, Dept Pharm, Lab Clin Pharmacol, Fac Sci, Rajshahi 6205, Bangladesh.
   [Hossain, Md. Farhad] Southeast Univ, Dept Pharm, Dhaka, Bangladesh.
C3 University of Rajshahi
RP Wahed, MII (corresponding author), Univ Rajshahi, Dept Pharm, Lab Clin Pharmacol, Fac Sci, Rajshahi 6205, Bangladesh.
EM drmirimam@gmail.com
RI Kali, Most Sumaiya Khatun/AAL-6648-2021; Wahed, Mir/AAS-4468-2020
OI Wahed, Mir Imam Ibne/0000-0002-3718-542X; Kumar Barman,
   Ranjan/0000-0001-5397-0164; Kali, Most. Sumaiya
   Khatun/0000-0002-3363-0303
FU Faculty of Science, University of Rajshahi [Science-22/2018-2019];
   Department of Pharmacy, University of Rajshahi, Bangladesh
FX This work was supported by Faculty of Science (Science-22/2018-2019),
   University of Rajshahi and the Department of Pharmacy, University of
   Rajshahi, Bangladesh.
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NR 75
TC 3
Z9 3
U1 1
U2 3
PU CELL PRESS
PI CAMBRIDGE
PA 50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA
EI 2405-8440
J9 HELIYON
JI Heliyon
PD JAN
PY 2022
VL 8
IS 1
AR e08671
DI 10.1016/j.heliyon.2021.e08671
EA JAN 2022
PG 11
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA ZQ6AF
UT WOS:000767184700021
PM 35028456
OA Green Published
DA 2025-06-11
ER

PT J
AU Mukherjee, AA
   Kandhare, AD
   Bodhankar, SL
AF Mukherjee, Anwesha A.
   Kandhare, Amit D.
   Bodhankar, Subhash L.
TI Elucidation of protective efficacy of Pentahydroxy flavone isolated from
   Madhuca indica against arsenite-induced cardiomyopathy: Role of
   Nrf-2, PPAR-γ, c-fos and c-jun
SO ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
LA English
DT Article
DE 3,5,7,3 ',4 '-Pentahydroxy flavone; Apoptosis; Cardiotoxicity; c-fos;
   c-jun; Nrf-2; PPAR-gamma; Sodium arsenite
ID INDUCED OXIDATIVE STRESS; SODIUM ARSENITE; VENTRICULAR HYPERTROPHY;
   STANDARDIZED EXTRACT; CARDIAC-HYPERTROPHY; CELL-PROLIFERATION; METABOLIC
   SYNDROME; INDUCED TOXICITY; RATS ROLE; NARINGIN
AB Background: Madhuca indica J. F. Gmel. (Sapotaceae) is widely used ethnobotanically as anti-diabetic, antipyretic, hepatoprotective, anti-inflammatory and analgesic. It was shown to possess potent anti-apoptotic property.
   The aim of the study: To evaluate the possible mechanism of action of isolated phytoconstituent from Madhuca indica Leaves methanolic extract (MI-ALC) on arsenic-induced cardiotoxicity in rats.
   Materials and methods: The 3,5,7,3',4'-Pentahydroxy flavone (QTN) was isolated and characterized by using HPTLC, H-1 NMR, and LC MS from MI-ALC. QTN (5, 10 and 20 mg/kg, p.o.) was administered in arsenic intoxicated rats (5 mL/kg, p.o.) for 28 days and evaluated for various behavioral, biochemical, molecular and ultra-histological changes.
   Results: Treatment with QTN (10 and 20 mg/kg, p.o.) significantly inhibited (p < 0.05) arsenic-induced electrocardiographic, hemodynamic and left ventricular function alterations. Elevated levels of cardiac markers (LDH, CK-MB, AST, ALT, and ALP), altered lipid metabolism (total cholesterol, triglyceride, LDL, HDL, and VLDL) was significantly restored (p < 0.05) by QTN. It also significantly inhibited (p < 0.05) altered cardiac oxido-nitrosative stress, Na-K-ATPase level and mitochondrial enzymes (I-IV) activity after arsenite administration. QTN significantly increased (p < 0.05) myocardial Nrf-2, PPAR-gamma and significantly decreased (p < 0.05) myocardial c-fos and c-jun mRNA expressions. Flow cytometric analysis showed that treatment with QTN (10 and 20 mg/kg) significantly inhibited (p < 0.05) arsenite-induce ROS and apoptosis. It also reduced ultra-histological aberrations induced by sodium arsenite.
   Conclusion: Administration of 3,5,7,3',4'- Pentahydroxy flavone (i.e. Quercetin (QTN)) isolated from MI-ALC showed significant protection against arsenic-induced oxido-nitrosative stress and myocardial injury via modulation of Nrf2, PPAR-gamma, and apoptosis.
C1 [Mukherjee, Anwesha A.; Kandhare, Amit D.; Bodhankar, Subhash L.] Bharati Vidyapeeth Deemed Univ, Poona Coll Pharm, Dept Pharmacol, Pune 411038, Maharashtra, India.
C3 Poona College of Pharmacy; Bharati Vidyapeeth Deemed University
RP Bodhankar, SL (corresponding author), Bharati Vidyapeeth Deemed Univ, Poona Coll Pharm, Dept Pharmacol, Pune 411038, Maharashtra, India.
EM drsbodh@gmail.com
RI Bodhankar, Sunhash/AAQ-4624-2020; Kandhare, Amit/E-2584-2011
OI Mukherjee, Anwesha/0000-0001-6387-028X; Kandhare,
   Amit/0000-0003-1523-2050; Bodhankar, Subhash/0000-0001-5168-2134
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NR 102
TC 34
Z9 34
U1 0
U2 18
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1382-6689
EI 1872-7077
J9 ENVIRON TOXICOL PHAR
JI Environ. Toxicol. Pharmacol.
PD DEC
PY 2017
VL 56
BP 172
EP 185
DI 10.1016/j.etap.2017.08.027
PG 14
WC Environmental Sciences; Pharmacology & Pharmacy; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Pharmacology & Pharmacy; Toxicology
GA FQ2XW
UT WOS:000418222300024
PM 28942082
DA 2025-06-11
ER

PT J
AU Wang, X
   Li, H
   Zheng, A
   Yang, L
   Liu, J
   Chen, C
   Tang, Y
   Zou, X
   Li, Y
   Long, J
   Liu, J
   Zhang, Y
   Feng, Z
AF Wang, X.
   Li, H.
   Zheng, A.
   Yang, L.
   Liu, J.
   Chen, C.
   Tang, Y.
   Zou, X.
   Li, Y.
   Long, J.
   Liu, J.
   Zhang, Y.
   Feng, Z.
TI Mitochondrial dysfunction-associated OPA1 cleavage contributes to muscle
   degeneration: preventative effect of hydroxytyrosol acetate
SO CELL DEATH & DISEASE
LA English
DT Article
ID OXIDATIVE STRESS; SKELETAL-MUSCLE; OLIVE OIL; PROTEOLYTIC CLEAVAGE;
   METABOLIC SYNDROME; HYDROGEN-PEROXIDE; PROTEIN OPA1; CELLS; CANCER;
   MORPHOLOGY
AB Mitochondrial dysfunction contributes to the development of muscle disorders, including muscle wasting, muscle atrophy and degeneration. Despite the knowledge that oxidative stress closely interacts with mitochondrial dysfunction, the detailed mechanisms remain obscure. In this study, tert-butylhydroperoxide (t-BHP) was used to induce oxidative stress on differentiated C2C12 myotubes. t-BHP induced significant mitochondrial dysfunction in a time-dependent manner, accompanied by decreased myosin heavy chain (MyHC) expression at both the mRNA and protein levels. Consistently, endogenous reactive oxygen species (ROS) overproduction triggered by carbonyl cyanide 4-(trifluoromethoxy) phenylhydrazone (FCCP), a mitochondrial oxidative phosphorylation inhibitor, was accompanied by decreased membrane potential and decreased MyHC protein content. However, the free radical scavenger N-acetyl-L-cysteine (NAC) efficiently reduced the ROS level and restored MyHC content, suggesting a close association between ROS and MyHC expression. Meanwhile, we found that both t-BHP and FCCP promoted the cleavage of optic atrophy 1 (OPA1) from the long form into short form during the early stages. In addition, the ATPase family gene 3-like 2, a mitochondrial inner membrane protease, was also markedly increased. Moreover, OPA1 knockdown in myotubes was accompanied by decreased MyHC content, whereas NAC failed to prevent FCCP-induced MyHC decrease with OPA1 knockdown, suggesting that ROS might affect MyHC content by modulating OPA1 cleavage. In addition, hydroxytyrosol acetate (HT-AC), an important compound in virgin olive oil, could significantly prevent t-BHP-induced mitochondrial membrane potential and cell viability loss in myotubes. Specifically, HT-AC inhibited t-BHP-induced OPA1 cleavage and mitochondrial morphology changes, accompanied by improvement on mitochondrial oxygen consumption capacity, ATP productive potential and activities of mitochondrial complex I, II and V. Moreover, both t-BHP-and FCCP-induced MyHC decrease was sufficiently inhibited by HT-AC. Taken together, our data provide evidence indicating that mitochondrial dysfunction-associated OPA1 cleavage may contribute to muscle degeneration, and olive oil compounds could be effective nutrients for preventing the development of muscle disorders.
C1 [Wang, X.; Li, H.; Zheng, A.; Yang, L.; Liu, J.; Chen, C.; Tang, Y.; Zou, X.; Li, Y.; Long, J.; Liu, J.; Feng, Z.] Xi An Jiao Tong Univ, Sch Life Sci & Technol, Ctr Mitochondrial Biol & Med, Key Lab Biomed Informat Engn,Minist Educ, Xian, Peoples R China.
   [Wang, X.; Li, H.; Zheng, A.; Yang, L.; Liu, J.; Chen, C.; Tang, Y.; Zou, X.; Li, Y.; Long, J.; Liu, J.; Feng, Z.] Xi An Jiao Tong Univ, Frontier Inst Sci & Technol, Xian, Peoples R China.
   [Liu, J.; Zhang, Y.] Tianjin Univ Sport, Tianjin Key Lab Exercise Physiol & Sports Med, Tianjin 300381, Peoples R China.
C3 Xi'an Jiaotong University; Ministry of Education - China; Xi'an Jiaotong
   University; Tianjin University of Sport
RP Zhang, Y (corresponding author), Tianjin Univ Sport, Tianjin Key Lab Exercise Physiol & Sports Med, 51 Weijin South Rd, Tianjin 300381, Peoples R China.
EM yzhang@tjus.edu.cn
RI Zou, Xuan/A-6452-2015; Long, Jiangang/A-7835-2015; Li, Hao/K-7001-2017;
   Feng, Zhihui/E-7408-2011
OI Feng, Zhihui/0000-0002-2448-6565; Wang, Xun/0000-0001-5172-0305; Li,
   Hao/0000-0001-5677-3377
FU National Natural Science Foundation of China [81201023, 31370844];
   Tianjin Science and Technology Planning Major Project [12JCZDJC34400];
   Tianjin Education committee Sci-Tech Development Major Project
   [20112D05]; Tianjin Key Labs and Tech-Platform Project [10SYSYJC28400];
   National 'Twelfth Five-Year' Plan for Science & Technology Support
   [2012BAH30F03]
FX We are supported by the National Natural Science Foundation of China
   (81201023, 31370844), Tianjin Science and Technology Planning Major
   Project (12JCZDJC34400), Tianjin Education committee Sci-Tech
   Development Major Project (20112D05), Tianjin Key Labs and Tech-Platform
   Project (10SYSYJC28400), National 'Twelfth Five-Year' Plan for Science &
   Technology Support (2012BAH30F03).
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NR 47
TC 54
Z9 54
U1 1
U2 18
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 2041-4889
J9 CELL DEATH DIS
JI Cell Death Dis.
PD NOV
PY 2014
VL 5
AR e1521
DI 10.1038/cddis.2014.473
PG 11
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA AU5JW
UT WOS:000345643900015
PM 25393477
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Maity, J
   Dey, T
   Banerjee, A
   Chattopadhyay, A
   Das, AR
   Bandyopadhyay, D
AF Maity, Juin
   Dey, Tiyasa
   Banerjee, Adrita
   Chattopadhyay, Aindrila
   Das, Asish R.
   Bandyopadhyay, Debasish
TI Melatonin ameliorates myocardial infarction in obese diabetic
   individuals: The possible involvement of macrophage apoptotic factors
SO JOURNAL OF PINEAL RESEARCH
LA English
DT Review
DE cardiovascular disease; diabetes; inflammation; macrophage apoptosis;
   myocardial infarction; obesity; oxidative stress
ID ADVANCED ATHEROSCLEROTIC LESIONS; CHOLESTEROL EFFLUX CAPACITY;
   CARDIOVASCULAR RISK-FACTORS; OXIDATIVE STRESS; INSULIN-RESISTANCE;
   METABOLIC SYNDROME; BETA-CELL; LIPOPROTEIN SUBFRACTIONS;
   ENDOPLASMIC-RETICULUM; ISCHEMIA-REPERFUSION
AB In recent days, the hike in obesity-mediated epidemics across the globe and the prevalence of obesity-induced cardiovascular disease has become one of the chief grounds for morbidity and mortality. This epidemic-driven detrimental events in the cardiac tissues start with the altered distribution and metabolism pattern of high-density lipoprotein and low-density lipoprotein (LDL) leading to cholesterol (oxidized LDL) deposition on the arterial wall and atherosclerotic plaque generation, followed by vascular spasms and infarction. Subsequently, obesity-triggered metabolic malfunctions induce free radical generation which may further trigger pro-inflammatory signaling and nuclear factor kappa-light-chain-enhancer of activated B cells transcriptional factor, thus inducing interferon-gamma, tumor necrosis factor-alpha, and inducible nitric oxide synthase. This terrifying cardiomyopathy can be further aggravated in type 2 diabetes mellitus, thereby making obese diabetic patients prone toward the development of myocardial infarction (MI) or stroke in comparison to their nondiabetic counterparts. The accelerated oxidative stress and pro-inflammatory response induced cardiomyocyte hypertrophy, followed by apoptosis in obese diabetic individuals, causing progression of athero-thrombotic vascular disease. Being an efficient antioxidative and anti-inflammatory indolamine, melatonin effectively inhibits lipid peroxidation, pro-inflammatory reactions, thereby resolving free radical-induced myocardial damages along with maintaining antioxidant reservoir to preserve cardiovascular integrity. Prolonged melatonin treatment maintains balanced body weight and serum total cholesterol concentration by inhibiting cholesterol synthesis and promoting cholesterol catabolism. Additionally, melatonin promotes macrophage polarization toward the anti-inflammatory state, providing a proper shield during the recovery period. Therefore, the protective role of melatonin in maintaining the lipid metabolism homeostasis and blocking the atherosclerotic plaque rupture could be targeted as the possible therapeutic strategy for the management of obesity-induced acute MI. This review aimed at orchestrating the efficacy of melatonin in ameliorating irrevocable oxidative cardiovascular damage induced by the obesity-diabetes correlation.
C1 [Maity, Juin; Dey, Tiyasa; Banerjee, Adrita; Bandyopadhyay, Debasish] Univ Calcutta, Dept Physiol, Oxidat Stress & Free Rad Biol Lab, Kolkata, India.
   [Chattopadhyay, Aindrila] Vidyasagar Coll, Dept Physiol, Kolkata, India.
   [Das, Asish R.] Univ Calcutta, Dept Chem, Kolkata, India.
   [Bandyopadhyay, Debasish] Univ Calcutta, Univ Coll Sci & Technol, Dept Physiol, 92 APC Rd, Kolkata 700009, India.
C3 University of Calcutta; University of Calcutta; University of Calcutta
RP Bandyopadhyay, D (corresponding author), Univ Calcutta, Univ Coll Sci & Technol, Dept Physiol, 92 APC Rd, Kolkata 700009, India.
EM debasish63@gmail.com
RI Bandyopadhyay, Debasish/AFC-7830-2022
OI BANERJEE, ADRITA/0000-0002-8535-6190; Bandyopadhyay,
   Debasish/0000-0001-7993-0777; Chattopadhyay,
   Aindrila/0000-0003-1371-6115
FU DST; UGC; WBDST; University of Calcutta; Departmental BI Grant
FX DST; UGC; WBDST; University of Calcutta; Departmental BI Grant
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NR 154
TC 13
Z9 13
U1 0
U2 19
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0742-3098
EI 1600-079X
J9 J PINEAL RES
JI J. Pineal Res.
PD MAR
PY 2023
VL 74
IS 2
DI 10.1111/jpi.12847
EA DEC 2022
PG 15
WC Endocrinology & Metabolism; Neurosciences; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Physiology
GA 9G1TT
UT WOS:000894625100001
PM 36456538
OA Bronze
DA 2025-06-11
ER

PT J
AU Pour, FK
   Aryaeian, N
   Mokhtare, M
   Parsa, RSM
   Jannani, L
   Agah, S
   Fallah, S
   Moradi, N
AF Pour, Farnaz Kaviani
   Aryaeian, Naheed
   Mokhtare, Marjan
   Parsa, Reyhane Sadat Mirnasrollahi
   Jannani, Leila
   Agah, Shahram
   Fallah, Sodabeh
   Moradi, Nariman
TI The effect of saffron supplementation on some inflammatory and oxidative
   markers, leptin, adiponectin, and body composition in patients with
   nonalcoholic fatty liver disease: A double-blind randomized clinical
   trial
SO PHYTOTHERAPY RESEARCH
LA English
DT Article
DE anthropometric measurements; body composition indexes; Crocus sativusL;
   inflammation; nonalcoholic fatty liver disease; oxidative stress
ID NECROSIS-FACTOR-ALPHA; CROCUS-SATIVUS L.; METABOLIC SYNDROME; LIPID
   PROFILE; TNF-ALPHA; ANTIOXIDANT; CONSTITUENT; SENSITIVITY; PARAMETERS;
   CROCETIN
AB Background Nonalcoholic fatty liver disease (NAFLD) is characterized by oxidative stress and inflammation in the hepatocytes.Saffron and its constituents are reported to have several properties such as anti-inflammatory and anti-diabetic effects. Materials and methods In a randomized double-blind placebo-controlled trial with two parallel groups including 76 eligible men and female patients with NAFLD aged 18-65, recruited from Hazrat Rasul Akram Hospital in Tehran, Iran. NAFLD was defined by a Gastroenterologist based on the American Gastrointestinal and Liver Association standards. Participants were randomly assigned to two groups receiving daily supplementation of either one tablet of 100 mg saffron (n= 38) or one placebo (n= 38) for 12 weeks. The primary outcome was high sensitive C-reactive protein (hs-CRP) and secondary outcomes were alanine aminotransferase (ALT), aspartate aminotransferase (AST), tumor necrosis factor alpha (TNF-alpha), malondialdehyde (MDA), total anti-oxidant capacity (TAC), leptin, adiponectin, anthropometric, and body composition Both groups were assigned similar diet and physical activity. Results In the treatment group, significant decreases in hs-CRP (-1.80 ng/ml, 95% CI = -2.97, -0.63,p= .032), leptin (-0.27 ng/ml, 95% CI = -0.65, -0.10,p= .040), MDA (-1.01 ng/ml, 95% CI = -1.89, -0.14,p= .023) and significant increase in TAC (0.34 mu mol/L, 95% CI = 0.08, 0.61,p= .011) were observed compared to the placebo group. However, there were no significant changes in serum alanine aminotransferase, AST, TNF-alpha, body composition, and anthropometric indexes (p > .05). Conclusion In the present study, 12 weeks of 100 mg of saffron supplementation indicated beneficial effects on serum levels of some inflammatory, oxidative stress, and adipokines biomarkers but it had no significant effect on serum concentrations of liver enzymes, anthropometric, and body composition measurements.
C1 [Pour, Farnaz Kaviani; Aryaeian, Naheed; Parsa, Reyhane Sadat Mirnasrollahi] Iran Univ Med Sci, Sch Publ Hlth, Dept Nutr, Hemmat Broadway, Tehran, Iran.
   [Mokhtare, Marjan; Agah, Shahram] Iran Univ Med Sci, Colorectal Res Ctr, Tehran, Iran.
   [Jannani, Leila] Iran Univ Med Sci, Dept Biostat, Tehran, Iran.
   [Fallah, Sodabeh] Iran Univ Med Sci, Fac Med, Dept Clin Biochem, Tehran, Iran.
   [Moradi, Nariman] Kurdistan Univ Med Sci, Fac Med, Dept Clin Biochem, Sanandaj, Iran.
C3 Iran University of Medical Sciences; Iran University of Medical
   Sciences; Iran University of Medical Sciences; Iran University of
   Medical Sciences; Kurdistan University of Medical Sciences
RP Aryaeian, N (corresponding author), Iran Univ Med Sci, Sch Publ Hlth, Dept Nutr, Hemmat Broadway, Tehran, Iran.
EM aryaeian.n@iums.ac.ir
RI Agah, Shahram/Y-5817-2018; Mokhtare, Marjan/L-4240-2018; Aryaeian,
   Naheed/H-3894-2018
OI Aryaeian, Naheed/0000-0001-9662-8561; Mirnasrollahi Parsa, Reyhane
   Sadat/0000-0002-7028-530X
FU Iran University of Medical Sciences
FX Iran University of Medical Sciences
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NR 40
TC 37
Z9 38
U1 0
U2 12
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0951-418X
EI 1099-1573
J9 PHYTOTHER RES
JI Phytother. Res.
PD DEC
PY 2020
VL 34
IS 12
BP 3367
EP 3378
DI 10.1002/ptr.6791
EA AUG 2020
PG 12
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA PC4GH
UT WOS:000559663400001
PM 32798261
DA 2025-06-11
ER

PT J
AU Eduardsen, K
   Larsen, SL
   Novak, I
   Lambert, IH
   Hoffmann, EK
   Pedersen, SF
AF Eduardsen, Kathrine
   Larsen, Susanne L.
   Novak, Ivana
   Lambert, Ian H.
   Hoffmann, Else K.
   Pedersen, Stine F.
TI Cell Volume Regulation and Signaling in 3T3-L1 Pre-adipocytes and
   Adipocytes: On the Possible Roles of Caveolae, Insulin Receptors, FAK
   and ERK1/2
SO CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
LA English
DT Article
DE RVD; RVI; ERK1/2; Insulin; Osmotic stress
ID ACTIVATED PROTEIN-KINASE; LETTRE ASCITES-CELLS; ANION CURRENT;
   PLASMA-MEMBRANE; CHOLESTEROL; CHANNELS; STRESS; SHOCK; INTERNALIZATION;
   TRANSLOCATION
AB Caveolae have been implicated in sensing of cell volume perturbations, yet evidence is still limited and findings contradictory. Here, we investigated the possible role of caveolae in cell volume regulation and volume sensitive signaling in an adipocyte system with high (3T3-L1 adipocytes); intermediate (3T3-L1 pre-adipocytes); and low (cholesterol-depleted 3T3L1 pre-adipocytes) caveolae levels. Using large-angle light scattering, we show that compared to preadipocytes, differentiated adipocytes exhibit severalfold increased rates of volume restoration following osmotic cell swelling (RVD) and osmotic cell shrinkage (RVI), accompanied by increased swelling-activated taurine efflux. However, caveolin-1 distribution was not detectably altered after osmotic swelling or shrinkage, and caveolae integrity, as studied by cholesterol depletion or expression of dominant negative Cav-1, was not required for either RVD or RVI in pre-adipocytes. The insulin receptor (InsR) localizes to caveolae and its expression dramatically increases upon adipocyte differentiation. In preadipocytes, InsR and its effectors focal adhesion kinase (FAK) and extracellular signal regulated kinase (ERK1/2) localized to focal adhesions and were activated by a 5 min exposure to insulin (100 nM). Osmotic shrinkage transiently inhibited InsR Y(146)-phosphorylation, followed by an increase at t = 15 min; a similar pattern was seen for ERK1/2 and FAK, in a manner unaffected by cholesterol depletion. In contrast, cell swelling had no detectable effect on InsR, yet increased ERK1/2 phosphorylation. In conclusion, differentiated 3T3-L1 adipocytes exhibit greatly accelerated RVD and RVI responses and increased swelling-activated taurine efflux compared to pre-adipocytes. Furthermore, in pre-adipocytes, Cav-1/caveolae integrity is not required for volume regulation. Given the relationship between hyperosmotic stress and insulin signaling, the finding that cell volume regulation is dramatically altered upon adipocyte differentiation may be relevant for the understanding of insulin resistance and metabolic syndrome. Copyright (C) 2011 S. Karger AG, Basel
C1 [Eduardsen, Kathrine; Larsen, Susanne L.; Novak, Ivana; Lambert, Ian H.; Hoffmann, Else K.; Pedersen, Stine F.] Univ Copenhagen, Dept Biol, DK-2100 Copenhagen, Denmark.
C3 University of Copenhagen
RP Pedersen, SF (corresponding author), Univ Copenhagen, Dept Biol, 13 Univ Pk, DK-2100 Copenhagen, Denmark.
EM sfpedersen@bio.ku.dk
RI hoffmann, Else/N-4101-2014; Lambert, Ian/J-6983-2014; Novak,
   Ivana/M-2791-2014; Pedersen, Stine Falsig/M-8347-2014
OI Novak, Ivana/0000-0002-8917-8010; Pedersen, Stine
   Falsig/0000-0002-3044-7714
FU Danish Natural Sciences Research Council; The Danish council for
   Independent Research / Medical Sciences
FX We are grateful to Dr. J. Vinten, University of Copenhagen and Dr. J.
   Eggermont, KU Leuven, Belgium, for their gifts of Cav-1 antibody and
   DN-Cav-1 plasmid, respectively, and to Birthe Juul Hansen for expert
   technical assistance. The present work was funded by grants from the
   Danish Natural Sciences Research Council (EKH, SFP, IHL, IN), and The
   Danish council for Independent Research / Medical Sciences (IHL).
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NR 47
TC 14
Z9 14
U1 1
U2 9
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1015-8987
J9 CELL PHYSIOL BIOCHEM
JI Cell. Physiol. Biochem.
PY 2011
VL 28
IS 6
BP 1231
EP 1246
DI 10.1159/000335855
PG 16
WC Cell Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Physiology
GA 867YH
UT WOS:000298490200017
PM 22179011
OA Bronze
DA 2025-06-11
ER

PT J
AU Alhaji, JH
   Pathak, D
   Ashfaq, F
   Alsayegh, AA
   Khatoon, F
   Almutairi, BJ
   Khan, MI
   Beg, MMA
AF Alhaji, Jwaher Haji
   Pathak, Divya
   Ashfaq, Fauzia
   Alsayegh, Abdulrahman A.
   Khatoon, Fahmida
   Almutairi, Bader Judaya
   Khan, Mohammad Idreesh
   Beg, Mirza Masroor Ali
TI Role of NQO1 Gene Involvement and Susceptibility of T2DM Among Saudi
   Arabia Population
SO REJUVENATION RESEARCH
LA English
DT Article
DE NQO1 genotype; type 2 diabetes; lipid; mRNA expression; vitamin D
ID NAD(P)H-QUINONE OXIDOREDUCTASE-1; C609T POLYMORPHISM; METABOLIC
   SYNDROME; DIABETES-MELLITUS; OXIDATIVE STRESS; CANCER-RISK; ASSOCIATION;
   EXPRESSION; SENSITIVITY
AB NQO1 disruption enhances susceptibility to oxidative stress during hyperglycemia and is a significant contributor to the development and progression of diabetes. Oxidative stress has been linked to several symptoms, including hyperglycemia, reactive oxygen species buildup, high blood pressure, and the expression of inflammatory markers. Therefore, the present research aimed to evaluate the genetic abnormality of NQO1 (rs1800566, C609T) gene polymorphism, expression, and vitamin-D level assessment among Type 2 diabetes mellitus (T2DM) patients. The study included 100 newly diagnosed T2DM cases and 100 healthy individuals as healthy controls. Total RNA was extracted from the whole blood using the TRIzol method, and further cDNA was synthesized, and expression was evaluated. There is a significant difference in NQO1 (rs1800566, C609T) genotype distribution among the T2DM patients and healthy controls (p = 0.04). Compared with the NQO1 CC wild-type genotype, the NQO1 CT heterozygous genotype had an odds ratio of 1.96 (1.08-3.55), and the NQO1 TT mutant type genotype had an odds ratio of 3.31 (0.61-17.77). Significantly decreased expression of NQO1 mRNA was observed with heterozygous CT (p < 0.0001) and homozygous mutant TT genotype (p = 0.0004), compared with homozygous wild-type CC genotype. NQO1 mRNA expression level was also compared with vitamin D levels among the T2DM patients. T2DM patients with vitamin D deficiency had 1.83-fold NQO1 mRNA expression, while vitamin D insufficient and sufficient T2DM cases had 3.31-fold (p < 0.0001) and 3.70-fold (p < 0.0001) NQO1 mRNA expression. It was concluded that NQO1 (rs1800566, C609T) CT and TT genotypes played a significant role in the worseness of type II diabetes mellitus, and decreased expression of NQO1 mRNA expression could be an essential factor for disease worseness as well as hypermethylation could be a factor for reduced expression leading to disease severity. The decreased NQO1 mRNA expression with heterozygous CT and mutant TT genotype associated with vitamin D deficiency may contribute to disease progression.
C1 [Alhaji, Jwaher Haji] King Saud Univ, Dept Hlth Sci, Coll Appl Studies & Community Serv, Riyadh, Saudi Arabia.
   [Pathak, Divya] Cent Drugs Stand Control Org, New Delhi, India.
   [Ashfaq, Fauzia; Alsayegh, Abdulrahman A.] Jazan Univ, Appl Med Sci Coll, Clin Nutr Dept, Jazan, Saudi Arabia.
   [Khatoon, Fahmida] Univ Hail, Coll Med, Dept Biochem, Hail, Saudi Arabia.
   [Almutairi, Bader Judaya] Al Rass Gen Hosp, Clin Nutr, Minist Hlth, Qasim, Saudi Arabia.
   [Khan, Mohammad Idreesh] Qassim Univ, Coll Appl Med Sci, Dept Basic Hlth Sci, POB 6666, Buraydah 51452, Saudi Arabia.
   [Beg, Mirza Masroor Ali] Alatoo Int Univ, Fac Med, Bishkek, Kyrgyzstan.
   [Beg, Mirza Masroor Ali] Alatoo Int Univ, Ctr Promot Med Res, Bishkek, Kyrgyzstan.
C3 King Saud University; Jazan University; University Ha'il; Qassim
   University
RP Khan, MI (corresponding author), Qassim Univ, Coll Appl Med Sci, Dept Basic Hlth Sci, POB 6666, Buraydah 51452, Saudi Arabia.; Beg, MMA (corresponding author), Alatoo Int Univ, Fac Med, Bishkek, Kyrgyzstan.
EM Moi.khan@qu.edu.sa; mirzamasroor1986@gmail.com
RI Khan, Mohammad/JAX-4119-2023; alhaji, jwaher/GVS-0003-2022; Khatoon, DR
   Fahmida/ABA-2277-2021
OI Ashfaq, Fauzia/0000-0003-3653-4381; Alhaji, Jawher/0000-0001-7473-3037
FU Deanship of Scientific Research; King Saud University, Riyadh, Saudi
   Arabia [RSPD2024R1013]
FX The authors appreciate the Deanship of Scientific Research and the
   researchers supporting Project number RSPD2024R1013at the King Saud
   University, Riyadh, Saudi Arabia.
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NR 45
TC 0
Z9 0
U1 0
U2 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1549-1684
EI 1557-8577
J9 REJUV RES
JI Rejuv. Res.
PD OCT 1
PY 2024
VL 27
IS 5
BP 145
EP 153
DI 10.1089/rej.2024.0032
EA JUL 2024
PG 9
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA I5X4K
UT WOS:001268104300001
PM 38959119
DA 2025-06-11
ER

PT J
AU Salyer, LG
   Wang, YJ
   Ma, XL
   Foryst-Ludwig, A
   Kintscher, U
   Chennappan, S
   Kontaridis, MI
   McKinsey, TA
AF Salyer, Lorien G.
   Wang, Yajing
   Ma, Xinliang
   Foryst-Ludwig, Anna
   Kintscher, Ulrich
   Chennappan, Saravanakkumar
   Kontaridis, Maria I.
   McKinsey, Timothy A.
TI Modulating the Secretome of Fat to Treat Heart Failure
SO CIRCULATION RESEARCH
LA English
DT Review
DE adipose tissue; heart failure; inflammation; secretome; United States
ID EPICARDIAL ADIPOSE-TISSUE; PRESERVED EJECTION FRACTION; OBSTRUCTIVE
   SLEEP-APNEA; CARDIAC-HYPERTROPHY; BROWN FAT; CARDIOVASCULAR-DISEASE;
   SCIENTIFIC STATEMENT; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   ENERGY-METABOLISM
AB Heart failure afflicts >6 million individuals in the United States alone and is associated with significant mortality (approximate to 40% within 5 years of diagnosis) and cost (estimated to exceed $70 billion in the United States by 2030). Obesity is a major risk factor for the development of heart failure. The contribution of excess adipose tissue to heart failure pathogenesis is multifactorial. For example, adipose tissue-driven inflammation contributes to the development of other cardiometabolic comorbidities, such as hypertension, leading to left ventricular pressure overload and adverse remodeling of the heart. Adipose tissue also functions as an endocrine organ, and altered secretion of proteins, lipid mediators, metabolites, and small extracellular vesicles (collectively referred to as the secretome) from dysfunctional fat can lead to cardiac inflammation and oxidative stress, which drive changes in structure and function of the heart. In this review, we begin with an overview of current therapies for obesity and what is known about how they influence the heart. Then we focus on mechanisms by which fat communicates with the heart via secreted factors and highlight druggable nodes in this circuit that could be exploited to develop next-generation therapies for heart failure.
C1 [Salyer, Lorien G.; McKinsey, Timothy A.] Univ Colorado, Dept Med, Div Cardiol, Anschutz Med Campus,12700 E 19th Ave,Box B139 NA80, Aurora, CO 80045 USA.
   [Salyer, Lorien G.; McKinsey, Timothy A.] Univ Colorado, Consortium Fibrosis Res & Translat, Anschutz Med Campus, Aurora, CO USA.
   [Wang, Yajing] Univ Alabama Birmingham, Dept Biomed Engn, Birmingham, AL USA.
   [Ma, Xinliang] Thomas Jefferson Univ, Dept Emergency Med, Philadelphia, PA USA.
   [Foryst-Ludwig, Anna; Kintscher, Ulrich] Charite Univ Med Berlin, Max Rubner Ctr Cardiovasc Metab Renal Res MRC, Inst Pharmacol, Berlin, Germany.
   [Foryst-Ludwig, Anna; Kintscher, Ulrich] Free Univ Berlin, Berlin, Germany.
   [Foryst-Ludwig, Anna; Kintscher, Ulrich] Humboldt Univ, Berlin, Germany.
   [Foryst-Ludwig, Anna; Kintscher, Ulrich] DZHK German Ctr Cardiovasc Res, Berlin, Germany.
   [Chennappan, Saravanakkumar; Kontaridis, Maria I.] Masonic Med Res Inst, Dept Biomed Res & Translat Med, Utica, NY USA.
   [Kontaridis, Maria I.] Beth Israel Deaconess Med Ctr, Dept Med, Div Cardiol, Boston, MA USA.
   [Kontaridis, Maria I.] Harvard Med Sch, Dept Biol Chem & Mol Pharmacol, Boston, MA USA.
C3 University of Colorado System; University of Colorado Anschutz Medical
   Campus; University of Colorado System; University of Colorado Anschutz
   Medical Campus; University of Alabama System; University of Alabama
   Birmingham; Thomas Jefferson University; Berlin Institute of Health;
   Free University of Berlin; Humboldt University of Berlin; Charite
   Universitatsmedizin Berlin; Free University of Berlin; Humboldt
   University of Berlin; German Centre for Cardiovascular Research; Masonic
   Medical Research Laboratory; Harvard University; Harvard University
   Medical Affiliates; Beth Israel Deaconess Medical Center; Harvard
   University; Harvard Medical School
RP McKinsey, TA (corresponding author), Univ Colorado, Dept Med, Div Cardiol, Anschutz Med Campus,12700 E 19th Ave,Box B139 NA80, Aurora, CO 80045 USA.
EM timothy.mckinsey@cuanschutz.edu
RI Kontaridis, Maria/AAN-9781-2021
OI Kontaridis, Maria/0000-0002-6121-0533
FU National Institutes of Health (NIH) [R01HL171711]; American Heart
   Association Collaborative Sciences Award [24CSA1255857]; American Heart
   Association [25POST1373908, 20TPA1293530]; German Centre for
   Cardiovascular Research (DZHK); Deutsche Forschungsgemeinschaft (DFG,
   German Research Foundation) [437531118-SFB-1470 (SFB-1470-A09)]; NIH
   [HL-96686, HL-123404, HL158612/HL167495, R01-HL122238, R01-HL102368];
   Department of Defense Lupus Impact Award [W81X-WH2110784]; American
   Heart Association Transformation Grant Awards [20TPA35490426,
   23TPA1065811]; Lupus and Allied Diseases, Inc; Masonic Medical Research
   Institute; Halfond-Weil Postdoctoral Fellowship
FX This work was supported by the National Institutes of Health (NIH) grant
   R01HL171711 and an American Heart Association Collaborative Sciences
   Award (24CSA1255857) to T.A. McKinsey. L.G. Salyer was supported by an
   American Heart Association postdoctoral fellowship (25POST1373908). A.
   Foryst-Ludwig and U. Kintscher are supported by the German Centre for
   Cardiovascular Research (DZHK), U. Kintscher is supported by Deutsche
   Forschungsgemeinschaft (DFG, German Research Foundation)-Project-ID
   437531118-SFB-1470 (SFB-1470-A0 9). NIH (HL-9668 6, to X. Ma and Y.
   Wang, multiple Principle Investigators; HL-1234 04 to X. Ma; HL158
   612/HL167495 to Y. Wang) and the American Heart Association
   (20TPA1293530 to Y.Wang). This work was supported by the NIH (grants
   R01-HL12223 8 and R01-HL10236 8), the Department of Defense Lupus Impact
   Award (W81X-WH2110784), the American Heart Association Transformation
   Grant Awards (20TPA35490426, 23TPA1065811), the Lupus and Allied
   Diseases, Inc, and the Masonic Medical Research Institute to M.I.
   Kontaridis; and by the Halfond-Weil Postdoctoral Fellowship to S.C.
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Z9 0
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U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0009-7330
EI 1524-4571
J9 CIRC RES
JI Circ.Res.
PD MAY 23
PY 2025
VL 136
IS 11
BP 1363
EP 1381
DI 10.1161/CIRCRESAHA.125.325593
PG 19
WC Cardiac & Cardiovascular Systems; Hematology; Peripheral Vascular
   Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Hematology
GA 2YD2Q
UT WOS:001494094400003
PM 40403114
DA 2025-06-11
ER

PT J
AU Kocabas, S
   Sanlier, N
AF Kocabas, Sule
   Sanlier, Nevin
TI The power of berries against cardiovascular diseases
SO NUTRITION REVIEWS
LA English
DT Review
DE Berries; blood lipids; cardiovascular disease; metabolism; polyphenol
ID LOW-DENSITY-LIPOPROTEIN; IMPROVES ENDOTHELIAL FUNCTION; C-REACTIVE
   PROTEIN; ANTIOXIDANT CAPACITY; BLOOD-PRESSURE; DOUBLE-BLIND; ARTERIAL
   STIFFNESS; OXIDATIVE STRESS; BLUEBERRY SUPPLEMENTATION; METABOLIC
   SYNDROME
AB Cardiovascular diseases (CVDs) pose a serious threat to human health and incidence is increasing gradually. Nutrition has an important impact on the prophylaxis and progression of CVD. In this article, general attention is drawn to the possible positive effects of berries on CVD. Polyphenols have beneficial effects on the vascular system by inhibiting low-density lipoprotein oxidation and platelet aggregation, lowering blood pressure, improving endothelial dysfunction, and attenuating antioxidant defense and inflammatory responses. This review provides an overview of the effects of berries for the prevention and treatment of CVDs. Berries contain several cardioprotective antioxidants, vitamins, and numerous phytochemicals, such as phenolic compounds, that have antioxidant properties and antiplatelet activity. Phytochemical compounds in their structures can modulate dissimilar signaling pathways related to cell survival, differentiation, and growth. Important health benefits of berries include their antioxidant roles and anti-inflammatory impacts on vascular function. The effectiveness and potential of polyphenols primarily depend on the amount of bioavailability and intake. Although circulating berry metabolites can improve vascular function, their biological activities, mechanisms of action, and in vivo interactions are still unknown. Analyzing human studies or experimental studies to evaluate the bioactivity of metabolites individually and together is essential to understanding the mechanisms by which these metabolites affect vascular function.
C1 [Kocabas, Sule; Sanlier, Nevin] Ankara Medipol Univ, Sch Hlth Sci, Dept Nutr & Dietet, TR-06050 Ankara, Turkiye.
C3 Ankara Medipol University
RP Sanlier, N (corresponding author), Ankara Medipol Univ, Sch Hlth Sci, Dept Nutr & Dietet, TR-06050 Ankara, Turkiye.
EM nevintekgul@gmail.com
RI KOCABAS, SULE/KFS-7244-2024; Sanlier, Nevin/W-7657-2018
OI Sanlier, Nevin/0000-0001-5937-0485; KOCABAS, SULE/0000-0002-2864-943X
FU Author contributions. S.K. and N.S. both contributed significantly to
   the work's conception, design, interpretation, and analysis, and read
   and approved the manuscript. S.K. drafted the article and N.S. provided
   critical revision of the article.
FX Author contributions. S.K. and N.S. both contributed significantly to
   the work's conception, design, interpretation, and analysis, and read
   and approved the manuscript. S.K. drafted the article and N.S. provided
   critical revision of the article.
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NR 107
TC 2
Z9 3
U1 2
U2 16
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0029-6643
EI 1753-4887
J9 NUTR REV
JI Nutr. Rev.
PD SEP 11
PY 2023
VL 82
IS 7
BP 963
EP 977
DI 10.1093/nutrit/nuad111
EA SEP 2023
PG 15
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA TN0Y0
UT WOS:001062405600001
PM 37695292
DA 2025-06-11
ER

PT J
AU Nasution, DLI
   Furuta, M
   Li, HH
   Zakaria, MN
   Takeshita, T
   Peres, MA
   Yamashita, Y
AF Nasution, Dewi L. I.
   Furuta, Michiko
   Li, Huihua
   Zakaria, Myrna Nurlatifah
   Takeshita, Toru
   Peres, Marco A.
   Yamashita, Yoshihisa
TI Longitudinal association between periodontal condition and glycaemic
   status in middle-aged adults: A cross-lagged panel analysis
SO JOURNAL OF CLINICAL PERIODONTOLOGY
LA English
DT Article
DE blood glucose; glycated haemoglobin A; oral health; periodontitis
ID PARTIAL RECORDING PROTOCOLS; METABOLIC SYNDROME; DIABETES-MELLITUS;
   GLYCATED HEMOGLOBIN; OXIDATIVE STRESS; DISEASE; CLASSIFICATION;
   DIAGNOSIS; MODELS
AB Aim To investigate the existence of a bidirectional temporal relationship between periodontal condition and glycaemic status.
   Materials and Methods This longitudinal study included 2198 participants with mean age 43.4 +/- 7.7 years, who underwent dental examinations in Yokohama, Japan, at two time points, 2003-2004 and 2008-2009, at an interval of 5 years. Periodontal condition was assessed by the mean value of probing pocket depth (PPD) and clinical attachment level (CAL). Glycaemic status was assessed by fasting glucose and glycated haemoglobin (HbA1c).
   Results The cross-lagged panel models showed the effect of HbA1c at baseline on mean PPD at follow-up (beta = 0.044, p = .039). There was a marginal effect of fasting glucose on the mean PPD (beta = 0.037, p = .059). It was similar to the effect of fasting glucose or HbAlc on mean CAL. However, in the opposite direction, no effect of mean PPD or CAL at baseline on fasting glucose or HbAlc at follow-up was identified.
   Conclusions This study demonstrated a unidirectional relationship between glycaemic status and periodontal condition. The study population, however, had mostly mild periodontitis. Future studies are needed to investigate the effect of periodontal condition on glycaemic status in patients with severe periodontitis.
C1 [Nasution, Dewi L. I.] Univ Padjadjaran, Fac Dent, Kabupaten Sumedang, West Java, Indonesia.
   [Nasution, Dewi L. I.] Univ Jenderal Achmad Yani, Fac Dent, Dept Periodontol, Cimahi, Indonesia.
   [Furuta, Michiko; Takeshita, Toru; Yamashita, Yoshihisa] Kyushu Univ, Fac Dent Sci, Div Oral Hlth Growth & Dev, Sect Prevent & Publ Hlth Dent, Fukuoka, Japan.
   [Furuta, Michiko; Li, Huihua; Peres, Marco A.] Natl Dent Ctr Singapore, Natl Dent Res Inst Singapore, Singapore, Singapore.
   [Li, Huihua; Peres, Marco A.] Duke NUS Med Sch, Hlth Serv & Syst Res Programme, Oral Hlth ACP, Singapore, Singapore.
   [Zakaria, Myrna Nurlatifah] Univ Malaya, Fac Dent, Dept Restorat Dent, Kuala Lumpur, Malaysia.
   [Zakaria, Myrna Nurlatifah] Univ Jenderal Achmad Yani, Fac Dent, Dept Operat Dent & Endodontol, Cimahi, Indonesia.
   [Takeshita, Toru] Kyushu Univ, Fac Dent Sci, OBT Res Ctr, Fukuoka, Japan.
   [Furuta, Michiko] Kyushu Univ, Fac Dent Sci, Div Oral Hlth Growth & Dev, Sect Prevent & Publ Hlth Dent, 3-1-1 Maidashi,Higashi Ku, Fukuoka, Japan.
C3 Universitas Padjadjaran; Universitas Jenderal Achmad Yani; Kyushu
   University; National University of Singapore; Universiti Malaya;
   Universitas Jenderal Achmad Yani; Kyushu University; Kyushu University
RP Furuta, M (corresponding author), Kyushu Univ, Fac Dent Sci, Div Oral Hlth Growth & Dev, Sect Prevent & Publ Hlth Dent, 3-1-1 Maidashi,Higashi Ku, Fukuoka, Japan.
EM mfuruta@dent.kyushu-u.ac.jp
RI Li, Huihua/B-8795-2012; Takeshita, Toru/AAT-2321-2021; Peres, Marco
   Aurelio/D-1623-2013; Zakaria, Myrna Nurlatifah/AAB-2139-2020
OI Peres, Marco Aurelio/0000-0002-8329-2808; Zakaria, Myrna
   Nurlatifah/0000-0002-7617-5611; Furuta, Michiko/0000-0002-7267-857X
FU JSPS KAKENHI [21K10229, 20H03901]; Realizing Diversity in the Research
   Environment from the Ministry of Education, Science, Sports and Culture
   of Japan; Grants-in-Aid for Scientific Research [21K10229] Funding
   Source: KAKEN
FX JSPS KAKENHI, Grant/Award Numbers:21K10229, 20H03901; Realizing
   Diversity in the Research Environment from the Ministry of Education,
   Science, Sports and Culture of Japan
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NR 36
TC 4
Z9 4
U1 1
U2 10
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0303-6979
EI 1600-051X
J9 J CLIN PERIODONTOL
JI J. Clin. Periodontol.
PD AUG
PY 2023
VL 50
IS 8
BP 1042
EP 1050
DI 10.1111/jcpe.13809
EA MAR 2023
PG 9
WC Dentistry, Oral Surgery & Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dentistry, Oral Surgery & Medicine
GA L7UJ8
UT WOS:000959901900001
PM 36935202
DA 2025-06-11
ER

PT J
AU Byeon, H
   Moon, Y
   Lee, S
   Son, GI
   Lee, EN
AF Byeon, Hangjin
   Moon, Yesol
   Lee, Seoeun
   Son, Gwang-Ic
   Lee, Eunil
TI Effect of the Marine Exercise Retreat Program on Thyroid-Related
   Hormones in Middle-Aged Euthyroid Women
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Article
DE thyroid hormones; TSH; Free T4; marine retreat program; blue-space;
   heart rate variability; euthyroid
ID HEART-RATE-VARIABILITY; HIGH-NORMAL TSH; AIR-POLLUTION; REFERENCE
   INTERVALS; METABOLIC SYNDROME; DIETARY IODINE; LIFE-STYLE; THYROTROPIN;
   ASSOCIATION; HYPERTHYROIDISM
AB This study aimed to investigate the effects of a marine exercise retreat program on thyroid-related hormone levels. A total of 62 middle-aged euthyroid women participated in a 6-day marine exercise retreat program. Using thyroid-stimulating hormone (TSH) and free thyroxine (fT4) hormone levels, the participants were divided into high and low-hormone-level groups. Despite decreased TSH and fT4 levels after the program, the factors influencing changes in each group were different. TSH levels were influenced by changes in the normalized low frequency (nLF) of heart rate variability and carbon monoxide (CO) from all the participants, and changes in body fat percentage, nLF, and nitrogen dioxide (NO2) exposure level in the high TSH group. fT4 levels were influenced by changes in body mass index (BMI), NO2 exposure, and particulate matter diameter of 10 mu m or less (PM10) exposure in all participants. Changes in BMI and CO exposure influenced the low fT4 group. Lastly, changes in the exercise stress test affected the high fT4 group. Thus, the marine exercise retreat program affected euthyroid thyroid-related hormone levels, and influencing factors differ depending on the initial value of the hormone.
C1 [Byeon, Hangjin; Lee, Eunil] Korea Univ, Coll Med, Dept Publ Hlth, Seoul 02841, South Korea.
   [Moon, Yesol; Lee, Seoeun; Son, Gwang-Ic; Lee, Eunil] Korea Univ, Grad Sch, Dept Biomed Sci, Seoul 02841, South Korea.
   [Moon, Yesol; Lee, Seoeun; Son, Gwang-Ic; Lee, Eunil] Korea Univ, Coll Med, Dept Prevent Med, Seoul 02841, South Korea.
C3 Korea University; Korea University Medicine (KU Medicine); Korea
   University; Korea University; Korea University Medicine (KU Medicine)
RP Lee, EN (corresponding author), Korea Univ, Coll Med, Dept Publ Hlth, Seoul 02841, South Korea.; Lee, EN (corresponding author), Korea Univ, Grad Sch, Dept Biomed Sci, Seoul 02841, South Korea.; Lee, EN (corresponding author), Korea Univ, Coll Med, Dept Prevent Med, Seoul 02841, South Korea.
EM eunil@korea.ac.kr
RI Lee, Eunil/AAF-8926-2021
OI Lee, Eunil/0000-0003-1524-5046; MOON, Yesol/0000-0001-9039-9593; Lee,
   Seoeun/0000-0002-0227-3649
FU Wando Marine Healing Blue Zone Creation Project - Presidential Committee
   for Balanced National Development in South Korea
FX This work was supported by the Wando Marine Healing Blue Zone Creation
   Project funded by the Presidential Committee for Balanced National
   Development in South Korea.
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NR 78
TC 0
Z9 0
U1 0
U2 8
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD JAN
PY 2023
VL 20
IS 2
AR 1542
DI 10.3390/ijerph20021542
PG 17
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA 8C0XW
UT WOS:000917341800001
PM 36674297
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU You, YH
   Guo, YZ
   Jia, P
   Zhuang, BB
   Cheng, Y
   Deng, HP
   Wang, XW
   Zhang, C
   Luo, SX
   Huang, B
AF You, Yuehua
   Guo, Yongzheng
   Jia, Ping
   Zhuang, Biaobiao
   Cheng, Yu
   Deng, Hongpei
   Wang, Xiaowen
   Zhang, Cheng
   Luo, Suxin
   Huang, Bi
TI Ketogenic diet aggravates cardiac remodeling in adult spontaneously
   hypertensive rats
SO NUTRITION & METABOLISM
LA English
DT Article
DE Ketogenic diet; Cardiac fibrosis; Hypertension; mTOR pathway; mTORC2
ID OXIDATIVE STRESS; LONG-TERM; HYPERTROPHY; MTOR; DYSFUNCTION; PRESSURE;
   INHIBITION; MANAGEMENT; TARGET
AB Background Ketogenic diet (KD) has been proposed to be an effective lifestyle intervention in metabolic syndrome. However, the effects of KD on cardiac remodeling have not been investigated. Our aim was to investigate the effects and the underling mechanisms of KD on cardiac remodeling in spontaneously hypertensive rats (SHRs). Methods 10-week-old spontaneously hypertensive rats were subjected to normal diet or ketogenic diet for 4 weeks. Then, their blood pressure and cardiac remodeling were assessed. Cardiac fibroblasts were isolated from 1- to 3-day-old neonatal pups. The cells were then cultured with ketone body with or without TGF-beta to investigate the mechanism in vitro. Results 4 weeks of KD feeding aggravated interstitial fibrosis and cardiac remodeling in SHRs. More interestingly, ketogenic diet feeding increased the activity of mammalian target of rapamyoin (mTOR) complex 2 pathway in the heart of SHRs. In addition, beta-hydroxybutyrate strengthened the progression of TGF-beta-induced fibrosis in isolated cardiac fibroblasts. mTOR inhibition reversed this effect, indicating that ketone body contributes to cardiac fibroblasts via mTOR pathway. Conclusions These data suggest that ketogenic diet may lead to adverse effects on the remodeling in the hypertensive heart, and they underscore the necessity to fully evaluate its reliability before clinical use.
C1 [You, Yuehua; Guo, Yongzheng; Jia, Ping; Zhuang, Biaobiao; Luo, Suxin; Huang, Bi] Chongqing Med Univ, Affiliated Hosp 1, Div Cardiol, Chongqing 400016, Peoples R China.
   [Cheng, Yu; Deng, Hongpei] Chongqing Med Univ, Inst Life Sci, Chongqing 400016, Peoples R China.
   [Wang, Xiaowen; Zhang, Cheng] Chongqing Med Univ, Affiliated Hosp 1, Dept Cardiothorac Surg, Chongqing 400016, Peoples R China.
C3 Chongqing Medical University; Chongqing Medical University; Chongqing
   Medical University
RP Luo, SX; Huang, B (corresponding author), Chongqing Med Univ, Affiliated Hosp 1, Div Cardiol, Chongqing 400016, Peoples R China.
EM luosuxin@hospital.cqmu.edu.cn; huangbi120@hospital.cgmu.edu.cn
RI Guo, Yongzheng/HKO-6400-2023
FU National Nature Science Foundation of China [81770479]; Chongqing basic
   science and frontier technology research
FX This work was funded by the National Nature Science Foundation of China
   (No.81770479 to BH) and Chongqing basic science and frontier technology
   research(No.cstc2017jcyjAX0330 to BH).
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NR 40
TC 24
Z9 27
U1 0
U2 11
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1743-7075
J9 NUTR METAB
JI Nutr. Metab.
PD OCT 26
PY 2020
VL 17
IS 1
AR 91
DI 10.1186/s12986-020-00510-7
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA OK1JN
UT WOS:000584407700001
PM 33117428
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Salman, MA
   Mikhail, HMS
   Abdelsalam, A
   Sultan, AA
   El-ghobary, M
   Ismail, AAM
   Abouelregal, TE
   AbdelAal, AA
   Shaaban, HE
   GabAllah, GMK
   Tourky, M
   Salman, AA
AF Salman, Mohamed Abdalla
   Mikhail, Hani Maurice Sabri
   Abdelsalam, Ahmed
   Sultan, Ahmed Abd El Aal
   El-ghobary, Mohamed
   Ismail, Amro Abdelaziz Mohammed
   Abouelregal, Tarek Elsayed
   AbdelAal, Alhoussein Alsayed
   Shaaban, Hossam El-Din
   GabAllah, Ghada M. K.
   Tourky, Mohamed
   Salman, Ahmed Abdallah
TI Improvement of Systemic Adipokines and Adipokine Hepatic Gene Expression
   After Laparoscopic Sleeve Gastrectomy
SO BARIATRIC SURGICAL PRACTICE AND PATIENT CARE
LA English
DT Article
DE adipokines; adipokine hepatic gene expression; laparoscopic sleeve
   gastrectomy
ID COLONY-ENHANCING FACTOR; BARIATRIC SURGERY; PLASMA LEPTIN; WEIGHT-LOSS;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; OXIDATIVE STRESS; OBESITY;
   INFLAMMATION; ADIPONECTIN
AB Introduction and Aim: Obesity is characterized by low-grade inflammation, which is depicted by an increase of proinflammatory cytokines and a decrease of anti-inflammatory cytokines. This study was designed to assess the changes of systemic adipokines and adipokines hepatic gene expression after laparoscopic sleeve gastrectomy (LSG).
   Patients and Methods: The current prospective work included 81 obese cases for whom LSG was done. Paired liver biopsies, weight changes, biomarkers for glucose homeostasis, and hepatic enzymes in addition to serum and hepatic mRNA gene expression of adipocytokines (adiponectin, leptin, resistin, and pre-B cell enhancing factor [PBEF]/Nampt/visfatin) were assayed at baseline and at 18 months after LSG.
   Results: At the end of follow-up period, the results showed that LSG significantly improved markers of glucose homeostasis, hepatic enzymes, in addition to both serum and hepatic expression levels of different adipokines. Moreover, our analysis showed a direct positive correlation between initial body mass index (BMI) and serum leptin, as well as a negative correlation between BMI and serum adiponectin values.
   Conclusion: Weight loss-induced LSG is parallelized with substantial amendments of insulin resistance in addition to changes of the serum and hepatic gene expression of adipokines toward antidiabetic and anti-inflammatory profile.
C1 [Salman, Mohamed Abdalla; Mikhail, Hani Maurice Sabri; Abdelsalam, Ahmed] Cairo Univ, Dept Gen Surg, Fac Med, Cairo, Egypt.
   [Sultan, Ahmed Abd El Aal] Al Azhar Univ, Dept Gen Surg, Fac Med, Cairo, Egypt.
   [El-ghobary, Mohamed; Ismail, Amro Abdelaziz Mohammed; Abouelregal, Tarek Elsayed; Salman, Ahmed Abdallah] Cairo Univ, Dept Internal Med, Fac Med, Cairo 11311, Egypt.
   [AbdelAal, Alhoussein Alsayed] Zagazig Univ, Dept Internal Med, Fac Med, Zagazig, Egypt.
   [Shaaban, Hossam El-Din] Natl Hepatol & Trop Med Res Inst, Dept Gastroenterol, Cairo, Egypt.
   [GabAllah, Ghada M. K.] Menoufia Univ, Dept Med Biochem, Fac Med, Shibin Al Kawm, Al Minufiyah, Egypt.
   [Tourky, Mohamed] Alawi Tunsi Hosp, Gen Surg, Mecca, Saudi Arabia.
C3 Egyptian Knowledge Bank (EKB); Cairo University; Egyptian Knowledge Bank
   (EKB); Al Azhar University; Egyptian Knowledge Bank (EKB); Cairo
   University; Egyptian Knowledge Bank (EKB); Zagazig University; Egyptian
   Knowledge Bank (EKB); National Hepatology & Tropical Medicine Research
   Institute (NHTMRI); Egyptian Knowledge Bank (EKB); Menofia University
RP Salman, AA (corresponding author), Cairo Univ, Dept Internal Med, Fac Med, Cairo 11311, Egypt.
EM awea844@gmail.com
RI Salman, Mohamed/AAN-7318-2020; Sultan, Ahmed/AAE-9820-2021; el-Ghobary,
   mohamed/JNT-4201-2023; Salman, Ahmed/AAO-9045-2020; Abdelsalam,
   Ahmed/AEI-3376-2022
OI Sultan, Ahmed/0000-0003-1097-2615; Tourky, Mohamed/0000-0002-4783-258X;
   Salman, Ahmed/0000-0003-0026-0841; Abdelsalam,
   Ahmed/0000-0002-8770-2202; Abouelregal, Tarek/0000-0002-9496-0912
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NR 48
TC 0
Z9 0
U1 0
U2 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 2168-023X
EI 2168-0248
J9 BARIATR SURG PRACT P
JI Bariatr. Surg. Pract. Patient Care
PD DEC 1
PY 2020
VL 15
IS 4
BP 223
EP 230
DI 10.1089/bari.2019.0069
EA APR 2020
PG 8
WC Nursing; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Surgery
GA PF6BX
UT WOS:000527597200001
DA 2025-06-11
ER

PT J
AU Jamous, RM
   Abu-Zaitoun, SY
   Akkawi, RJ
   Ali-Shtayeh, MS
AF Jamous, Rana M.
   Abu-Zaitoun, Salam Y.
   Akkawi, Rola J.
   Ali-Shtayeh, Mohammed S.
TI Antiobesity and Antioxidant Potentials of Selected Palestinian Medicinal
   Plants
SO EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Article
ID CERATONIA-SILIQUA L.; DIET-INDUCED OBESITY; CURCUMA-LONGA L.;
   SARCOPOTERIUM-SPINOSUM; OXIDATIVE STRESS; ESSENTIAL OILS; ETHNOBOTANICAL
   SURVEY; METABOLIC SYNDROME; PHENOLIC-COMPOUNDS; PHELLINUS-LINTEUS
AB We evaluated the antioxidant and porcine pancreatic lipase inhibition (PPLI) activities of 90 plants extracts. The antioxidant activity was measured using the free-radical scavenging capacity (DPPH) and reducing power (RP) assays. The pancreatic lipase inhibition assay was used to determine the PPLI activity of plant extracts. Among the 90 plant extracts examined, 41.0% crude extracts showed antilipase activity of more than 50%. The most active plants by means of IC50 value were Camellia sinensis (0.5 mg/ml), Ceratonia siliqua (leaves) (0.8 mg/mL), Curcuma longa (0.8 mg/mL), Sarcopoterium spinosum (1.2 mg/mL), and Mentha spicata (1.2 mg/mL). The antioxidant activity of plant extracts using the DPPH and RP assays reveals comparable results. The most active antioxidant extracts using both assays were the leaves and fruit epicarp of Rhus coriaria, areal parts of Sarcopoterium spinosum, and leaves of Ceratonia siliqua. Our results suggest natural resources that possess strong antioxidant and pancreatic lipase inhibitory activities with potential applications in the treatment and prevention of obesity and overweight. The extracts of Camellia sinensis, Ceratonia siliqua, Curcuma longa, Sarcopoterium spinosum, and Mentha spicata were proved to have a great potential as antioxidants and antiobesity agents.
C1 [Jamous, Rana M.; Abu-Zaitoun, Salam Y.; Akkawi, Rola J.; Ali-Shtayeh, Mohammed S.] BERC, Til, Nablus, Palestine.
RP Ali-Shtayeh, MS (corresponding author), BERC, Til, Nablus, Palestine.
EM msshtayeh@yahoo.com
RI Ali-Shtayeh, Mohammed/C-3393-2014; Jamous, Rana/J-3266-2015
OI Jamous, Rana/0000-0002-3131-7807; abu zaitoun,
   salam/0000-0002-9658-6573; ali-shtayeh, Mohammed
   Saleem/0000-0001-9795-4238
FU Biodiversity & Environmental Research Center (BERC)
FX This research was funded by the Biodiversity & Environmental Research
   Center (BERC).
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NR 100
TC 37
Z9 37
U1 1
U2 15
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1741-427X
EI 1741-4288
J9 EVID-BASED COMPL ALT
JI Evid.-based Complement Altern. Med.
PY 2018
VL 2018
AR 8426752
DI 10.1155/2018/8426752
PG 21
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA GM2MB
UT WOS:000437919100001
PM 30026782
OA Green Published, Green Submitted, hybrid
DA 2025-06-11
ER

PT J
AU Kerimi, A
   Williamson, G
AF Kerimi, Asimina
   Williamson, Gary
TI At the interface of antioxidant signalling and cellular function: Key
   polyphenol effects
SO MOLECULAR NUTRITION & FOOD RESEARCH
LA English
DT Review
DE Endothelial function; Flavonoid; Inflammation; Phenolic acid; Uric acid
ID NF-KAPPA-B; NITRIC-OXIDE SYNTHASE; PLASMA URIC-ACID; CARDIOVASCULAR
   RISK-FACTORS; VEIN ENDOTHELIAL-CELL; SMOOTH-MUSCLE-CELLS; FATTY
   LIVER-DISEASE; OXIDATIVE STRESS; IN-VITRO; XANTHINE-OXIDASE
AB The hypothesis that dietary (poly) phenols promote well-being by improving chronic disease-risk biomarkers, such as endothelial dysfunction, chronic inflammation and plasma uric acid, is the subject of intense current research, involving human interventions studies, animal models and in vitro mechanistic work. The original claim that benefits were due to the direct antioxidant properties of (poly) phenols has been mostly superseded by detailed mechanistic studies on specific molecular targets. Nevertheless, many proposed mechanisms in vivo and in vitro are due to modulation of oxidative processes, often involving binding to specific proteins and effects on cell signalling. We review the molecular mechanisms for 3 actions of (poly) phenols on oxidative processes where there is evidence in vivo from human intervention or animal studies. (1) Effects of (poly) phenols on pathways of chronic inflammation leading to prevention of some of the damaging effects associated with the metabolic syndrome. (2) Interaction of (poly) phenols with endothelial cells and smooth muscle cells, leading to effects on blood pressure and endothelial dysfunction, and consequent reduction in cardiovascular disease risk. (3) The inhibition of xanthine oxidoreductase leading to modulation of intracellular superoxide and plasma uric acid, a risk factor for developing type 2 diabetes.
C1 [Kerimi, Asimina; Williamson, Gary] Univ Leeds, Sch Food Sci & Nutr, Leeds, W Yorkshire, England.
C3 University of Leeds
RP Williamson, G (corresponding author), Univ Leeds, Sch Food Sci & Nutr, Leeds, W Yorkshire, England.
EM g.williamson@leeds.ac.uk
RI Williamson, Gary/AAE-9665-2019
OI Williamson, Gary/0000-0002-5624-6267
FU ERC [322467]; EU [312090]; Nestle; Florida Department of Citrus;
   conducted consultancy for Nutrilite, USA; Suntory, UK; European Research
   Council (ERC) [322467] Funding Source: European Research Council (ERC)
FX A.K. and G.W. are funded by the ERC advanced grant "POLY-TRUE?" (322467)
   and the EU framework 7 project BACCHUS "Beneficial effects of dietary
   bioactive peptides and polyphenols on cardiovascular health in humans,"
   grant agreement number 312090.GW has recently, or currently, received
   research funding from Nestle and Florida Department of Citrus, and
   conducted consultancy for Nutrilite, USA, and Suntory, UK.
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NR 200
TC 53
Z9 57
U1 1
U2 57
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1613-4125
EI 1613-4133
J9 MOL NUTR FOOD RES
JI Mol. Nutr. Food Res.
PD AUG
PY 2016
VL 60
IS 8
SI SI
BP 1770
EP 1788
DI 10.1002/mnfr.201500940
PG 19
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA DV5JV
UT WOS:000382964200003
PM 26887821
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Zhu, SL
   Ma, L
   Wu, YZ
   Ye, XL
   Zhang, TY
   Zhang, QY
   Rasoul, LM
   Liu, YY
   Guo, M
   Zhou, B
   Ren, GP
   Li, DS
AF Zhu, Shenglong
   Ma, Lei
   Wu, Yunzhou
   Ye, Xianlong
   Zhang, Tianyuan
   Zhang, Qingyang
   Rasoul, Lubna Muhi
   Liu, Yunye
   Guo, Mo
   Zhou, Bing
   Ren, Guiping
   Li, Deshan
TI FGF21 treatment ameliorates alcoholic fatty liver through activation of
   AMPK-SIRT1 pathway
SO ACTA BIOCHIMICA ET BIOPHYSICA SINICA
LA English
DT Article
DE alcoholic fatty liver; fibroblast growth factor 21 (FGF21); AMPK; SIRT1
ID PROTEIN-KINASE; METABOLISM; ETHANOL; MODEL
AB Fibroblast growth factor 21 (FGF21), a recently identified member of the FGF superfamily, is mainly secreted from the liver and adipose tissues and plays an important role in improving metabolic syndrome and homeostasis. The aim of this study is to evaluate the role of FGF21 in alcoholic fatty liver disease (AFLD) and to determine if it has a therapeutic effect on AFLD. In this paper, we tested the effect of FGF21 on alcohol-induced liver injury in a murine model of chronic ethanol gavage and alcohol-treated HepG2 cells. Male KM mice received single dose of 5 g/kg ethanol gavage every day for 6 weeks, which induced significant fatty liver and liver injury. The alcohol-induced fatty liver cell model was achieved by adding ethanol into the medium of HepG2 cell cultures at a final concentration of 75 mM for 9 days. Results showed that treatment with recombinant FGF21 ameliorated alcoholic fatty liver and liver injury both in a murine model of chronic ethanol gavage and alcohol-treated HepG2 cells. In addition, FGF21 treatment down-regulated the hepatic expression of fatty acid synthetic key enzyme, activated hepatic AMPK-SIRT1 pathway and significantly down-regulated hepatic oxidative stress protein. Taken together, FGF21 corrects multiple metabolic parameters of AFLD in vitro and in vivo by activation of the AMPK-SIRT1 pathway.
C1 [Zhu, Shenglong; Ma, Lei; Wu, Yunzhou; Ye, Xianlong; Zhang, Qingyang; Rasoul, Lubna Muhi; Liu, Yunye; Guo, Mo; Zhou, Bing; Ren, Guiping; Li, Deshan] Northeast Agr Univ, Sch Life Sci, Harbin 150001, Peoples R China.
   [Zhu, Shenglong] Jiangnan Univ, State Key Lab Food Sci & Technol, Sch Food Sci & Technol, Wuxi 214122, Peoples R China.
   [Ma, Lei] Chinese Acad Agr Sci, Harbin Vet Res Inst, Harbin 150001, Peoples R China.
   [Zhang, Tianyuan] China Agr Univ, Beijing 10008, Peoples R China.
   [Rasoul, Lubna Muhi] Univ Baghdad, Sch Life Sci, Baghdad 999048, Iraq.
   [Li, Deshan] Northease Agr Univ, Key Lab Agr Biol Funct Gene, Harbin 150001, Peoples R China.
C3 Northeast Agricultural University - China; Jiangnan University; Chinese
   Academy of Agricultural Sciences; Harbin Veterinary Research Institute,
   CAAS; China Agricultural University; University of Baghdad; Northeast
   Agricultural University - China
RP Ren, GP (corresponding author), Northeast Agr Univ, Sch Life Sci, Harbin 150001, Peoples R China.
EM renguiping@126.com; deshanli@163.com
RI Ye, Xianlong/HTP-9257-2023; Zhang, Tianyuan/HTM-1005-2023; Guo,
   Mo/LTD-9000-2024; Rasoul, Lubna/ABA-6811-2020; Zhu,
   Shenglong/AAJ-1030-2020
OI zhu, shenglong/0000-0003-0145-7339; Ye, Xianlong/0000-0002-6620-3957;
   Rasoul, Lubna/0000-0001-9836-1151
FU Heilongjiang Development and Reform Commission [[2011]1570];
   Heilongjiang Education Department [1252CGZH29]; Heilongjiang Education
   Department of Science and Technology Research Project [12521z004];
   Harbin Special Funds for Technological Innovation Research Projects
   [2012RFXX-S034]; Heilongjiang Postdoctoral Scientific Research
   Foundation [LBH-Q09162]; National Natural Science Foundation of China
   [J1210069/J0106]
FX This work was supported by the grants from the Heilongjiang Development
   and Reform Commission ([2011]1570); Heilongjiang Education Department
   (1252CGZH29); the Heilongjiang Education Department of Science and
   Technology Research Project (12521z004); the Harbin Special Funds for
   Technological Innovation Research Projects (2012RFXX-S034); the
   Heilongjiang Postdoctoral Scientific Research Foundation (LBH-Q09162);
   and the National Natural Science Foundation of China (J1210069/J0106).
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NR 25
TC 75
Z9 87
U1 2
U2 41
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1672-9145
EI 1745-7270
J9 ACTA BIOCH BIOPH SIN
JI Acta Biochim. Biophys. Sin.
PD DEC
PY 2014
VL 46
IS 12
BP 1041
EP 1048
DI 10.1093/abbs/gmu097
PG 8
WC Biochemistry & Molecular Biology; Biophysics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics
GA AU7KA
UT WOS:000345778200005
PM 25355486
DA 2025-06-11
ER

PT J
AU Zhao, Y
   Yang, XB
   Ren, DY
   Wang, DY
   Xuan, Y
AF Zhao, Yan
   Yang, Xingbin
   Ren, Daoyuan
   Wang, Dongying
   Xuan, Yang
TI Preventive effects of jujube polysaccharides on fructose-induced insulin
   resistance and dyslipidemia in mice
SO FOOD & FUNCTION
LA English
DT Article
ID FED RATS; OXIDATIVE STRESS; METABOLIC SYNDROME; DIETARY FRUCTOSE;
   EXTRACT; RICH; CHOLESTEROL; HOMEOSTASIS; GLUCOSE; MIXTURE
AB High fructose intake is associated with adverse metabolic syndromes. This study was designed to investigate whether the polysaccharides derived from Zizyphus jujube cv. Shaanbeitanzao (ZSP) could alleviate high fructose-induced insulin resistance and dystipidemia in mice. ZSP was identified by capillary zone electrophoresis as an acidic heteropolysaccharide with L-arabinose, D-galactose and D-galacturonic acid being the main component monosaccharides. Mice were provided with 20% high-fructose water and ZSP was administered intragastrically at doses of 0, 200 or 400 mg kg(-1) BW for 4 weeks. Fructose-treated mice showed hyperglycemia, hyperinsulinemia and dystipidemia with impaired insulin sensitivity (p < 0.05). Administration of ZSP at a dose of 400 mg kg(-1) BW significantly reduced the serum levels of glucose, insulin, TC, TG, LDL-C, and VLDL-C (p < 0.01). ZSP also markedly improved the HDL-C level, homeostasis model assessment for insulin resistance (HOMA-IR) and beta-cell function (HOMA-beta), and decreased the atherogenic index (AI) of the mice exposed to high-fructose water. Histopathological test with H&E and oil red O staining confirmed liver steatosis induced by a high-fructose diet and the hepatoprotective effect of ZSP. These findings indicate that the jujube polysaccharides may ameliorate insulin resistance and dyslipidemia in fructose-treated mice.
C1 [Zhao, Yan] Fourth Mil Med Univ, Sch Pharm, Xian 710032, Peoples R China.
   [Yang, Xingbin; Ren, Daoyuan; Wang, Dongying; Xuan, Yang] Shaanxi Normal Univ, Coll Food Engn & Nutr Sci, Xian 710062, Peoples R China.
C3 Air Force Medical University; Shaanxi Normal University
RP Zhao, Y (corresponding author), Fourth Mil Med Univ, Sch Pharm, Xian 710032, Peoples R China.
EM yanzhao@fmmu.edu.cn
RI WANG, Dongying/AAE-4967-2022
OI zhao, yan/0000-0002-7829-5975
FU National Natural Science Foundation of China [C31171678]; Fundamental
   Research Funds for the Central Universities of Shaanxi Normal
   University, China [GK201103004]
FX This study was financially supported by grants from the National Project
   of the National Natural Science Foundation of China (C31171678) and the
   Fundamental Research Funds for the Central Universities of Shaanxi
   Normal University, China (GK201103004).
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NR 35
TC 47
Z9 52
U1 5
U2 118
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PD AUG
PY 2014
VL 5
IS 8
BP 1771
EP 1778
DI 10.1039/c3fo60707k
PG 8
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA AN6IO
UT WOS:000340698400012
PM 24906476
DA 2025-06-11
ER

PT S
AU Ng, DS
AF Ng, Dominic S.
BE Litwack, G
TI Lecithin Cholesterol Acyltransferase Deficiency Protects from
   Diet-Induced Insulin Resistance and Obesity-Novel Insights from Mouse
   Models
SO OBESITY
SE Vitamins and Hormones
LA English
DT Review; Book Chapter
ID ENDOPLASMIC-RETICULUM STRESS; LOW-DENSITY-LIPOPROTEIN; BONE
   MORPHOGENETIC PROTEIN-7; LECITHIN/CHOLESTEROL ACYLTRANSFERASE; CHEMICAL
   CHAPERONES; METABOLIC DISEASE; FAMILIAL LECITHIN; LCAT DEFICIENCY; WHITE
   FAT; NULL MICE
AB Reduced plasma level of high-density lipoprotein cholesterol is an independent risk factor for atherosclerotic heart disease and is also a major diagnostic feature for the metabolic syndrome. Lecithin cholesterol acyltransferase (LCAT), an enzyme mediating the esterification of cholesterol in circulating lipoproteins, is one of the major modulators of high-density lipoprotein levels and composition. Loss-of-function mutations of LCAT invariably results in profound HDL deficiency and also modest hypertriglyceridemia (HTG). While intense effort has been devoted to investigate the role of LCAT in atherogenesis, which remains controversial, much less is known about whether LCAT also modulates glucose and energy homeostasis. In recent years, findings from studying the LCAT knockout mice began to suggest that LCAT deficiency, in spite of its unfavorable high triglyceride/low HDL lipid phenotypes, may confer protection from the development of insulin resistance and obesity. To date, alterations in specific metabolic pathways in liver, white adipose tissue, and skeletal muscle have been implicated. A better mechanistic understanding in the metabolic linkage between the primary biochemical action of LCAT and the downstream protective phenotypes will greatly facilitate the identification of potential novel pathways and targets in the treatment of obesity and diabetes.
C1 [Ng, Dominic S.] St Michaels Hosp, Keenan Res Ctr, Li Ka Shing Knowledge Inst, Toronto, ON M5B 1W8, Canada.
   [Ng, Dominic S.] Univ Toronto, Dept Med, Toronto, ON, Canada.
C3 University of Toronto; Li Ka Shing Knowledge Institute; Saint Michaels
   Hospital Toronto; University of Toronto
RP Ng, DS (corresponding author), St Michaels Hosp, Keenan Res Ctr, Li Ka Shing Knowledge Inst, 30 Bond St, Toronto, ON M5B 1W8, Canada.
EM ngd@smh.ca
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NR 43
TC 5
Z9 5
U1 0
U2 16
PU ELSEVIER ACADEMIC PRESS INC
PI SAN DIEGO
PA 525 B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0083-6729
BN 978-0-12-407766-9
J9 VITAM HORM
JI Vitam. Horm.
PY 2013
VL 91
BP 259
EP 270
DI 10.1016/B978-0-12-407766-9.00011-0
PG 12
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Book Citation Index – Science (BKCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA BDY03
UT WOS:000315604000011
PM 23374720
DA 2025-06-11
ER

PT J
AU Schaefer, C
   Biermann, T
   Schroeder, M
   Fuhrhop, I
   Niemeier, A
   Rüther, W
   Algenstaedt, P
   Hansen-Algenstaedt, N
AF Schaefer, Christian
   Biermann, Tanja
   Schroeder, Malte
   Fuhrhop, Ina
   Niemeier, Andreas
   Ruether, Wolfgang
   Algenstaedt, Petra
   Hansen-Algenstaedt, Nils
TI Early microvascular complications of prediabetes in mice with impaired
   glucose tolerance and dyslipidemia
SO ACTA DIABETOLOGICA
LA English
DT Article
DE Metabolic syndrome; Prediabetes; Intravital microscopy;
   Microcirculation; Microvascular complications; Type 2 diabetes
ID ENDOTHELIAL DYSFUNCTION; TRANSGENIC MICE; BROWN FAT;
   DIABETIC-RETINOPATHY; OXIDATIVE STRESS; LIPID LEVELS; TUMOR;
   ANGIOGENESIS; ADHESION; OBESITY
AB Microvascular complications are an important cause of morbidity in diabetic patients and can be detected in a significant number of patients at the time of diabetes diagnosis. However, little is known about the alterations in the microvasculature previous to the clinical manifestation of diabetes mellitus type 2. To obtain more insights into the early microvascular deterioration resulting from prediabetes, morphological and functional microvascular parameters were monitored using intravital fluorescence microscopy through a dorsal skin-fold chamber preparation in the uncoupling promotor-driven diphtheria toxin A chain (UCP1/DTA) mice. At the age of 12 weeks, the UCP1/DTA-mice were characterized by impaired glucose tolerance with concurrent unchanged fasting glucose, as well as dyslipidemia, hyperinsulinemia, hypertension and obesity. Prediabetic mice displayed combined hypertriglyceridemia and hypercholesterinemia. Associated with these prediabetic metabolic alterations, we demonstrate that microvascular density showed a dramatic decrease due to a reduction in perfused small vessels. A reduction in vascular density combined with unaltered blood flow in single vessels resulted in impaired tissue perfusion. Endothelial dysfunction with subsequently increased microvascular permeability and leukocyte-endothelium interactions were found. Our results of profound microvascular alterations at stages of normal fasting glucose underline the importance of early screening for prediabetes and associated microvascular complications.
C1 [Schaefer, Christian; Schroeder, Malte; Fuhrhop, Ina; Hansen-Algenstaedt, Nils] Univ Med Ctr Hamburg Eppendorf, Spine Ctr, D-20246 Hamburg, Germany.
   [Schaefer, Christian; Schroeder, Malte; Fuhrhop, Ina; Niemeier, Andreas; Ruether, Wolfgang; Hansen-Algenstaedt, Nils] Univ Med Ctr Hamburg Eppendorf, Dept Orthoped, D-20246 Hamburg, Germany.
   [Biermann, Tanja] Univ Med Ctr Hamburg Eppendorf, Dept Trauma Hand & Reconstruct Surg, D-20246 Hamburg, Germany.
   [Algenstaedt, Petra] Univ Med Ctr Hamburg Eppendorf, Dept Internal Med 3, D-20246 Hamburg, Germany.
C3 University of Hamburg; University Medical Center Hamburg-Eppendorf;
   University of Hamburg; University Medical Center Hamburg-Eppendorf;
   University of Hamburg; University Medical Center Hamburg-Eppendorf;
   University of Hamburg; University Medical Center Hamburg-Eppendorf
RP Schaefer, C (corresponding author), Univ Med Ctr Hamburg Eppendorf, Spine Ctr, Martinistr 52, D-20246 Hamburg, Germany.
EM c.schaefer@uke.uni-hamburg.de
FU Werner-Otto Stiftung research grant
FX This work was supported by a Werner-Otto Stiftung research grant to N.
   H.-A. We thank B. Schwarzloh for outstanding technical support.
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NR 45
TC 22
Z9 28
U1 0
U2 10
PU SPRINGER-VERLAG ITALIA SRL
PI MILAN
PA VIA DECEMBRIO, 28, MILAN, 20137, ITALY
SN 0940-5429
EI 1432-5233
J9 ACTA DIABETOL
JI Acta Diabetol.
PD DEC
PY 2010
VL 47
SU 1
BP S19
EP S27
DI 10.1007/s00592-009-0114-7
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 752GR
UT WOS:000289680000004
PM 19367364
DA 2025-06-11
ER

PT J
AU de Medeiros, TD
   Pereira, AT
   da Silva, FS
   Bortolin, RH
   Taveira, KVM
   Abreu, BJDA
   de Rezende, AA
   Farias, NBD
   Barbosa, JM
   Medeiros, KCD
AF de Medeiros, Tessio David
   Pereira, Annyelly Tavares
   da Silva, Flavio Santos
   Bortolin, Raul Hernandes
   Meira Taveira, Karinna Verissimo
   da Graca Azevedo Abreu, Bento Joao
   de Rezende, Adriana Augusto
   da Silva Farias, Naisandra Bezerra
   Barbosa Filho, Jose Maria
   de Paula Medeiros, Karina Carla
TI Ethanol extract of Cissampelos sympodialis ameliorates lung
   tissue damage in streptozotocin-induced diabetic rats
SO BRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCES
LA English
DT Article
DE Cissampelos sympodialis; Diabetes; Lung; Pancreatic islets; Lipid
   profile
ID OXIDATIVE STRESS; LIPID PROFILE; WARIFTEINE; EICHL; ACTIVATION;
   EXPRESSION; MILONINE; ALLERGY; LEAVES; MODEL
AB Diabetes Mellitus (DM) is a metabolic syndrome characterized by hyperglycemia. Chronic complications affect a number of organs, including the lungs. Cissampelos sympodialis Eichl (Menispennaceae) is a plant used to treat respiratory diseases. The aim of this study was to evaluate the effect of Cissampelos sympodialis extract (CSE) in lungs of diabetic rats. We used 30 Wistar rats divided into three groups: control group (CG), diabetic group (DG) and diabetic Cissampelos sympodialis treatment group (DTG). Diabetes was induced by streptozotocin (40 mg/kg i.v.). The CSE (400 mg/kg, po) was administered daily, during four weeks, beginning one week after the onset of DM. The treatment with CSE was not able to reduce blood glucose levels after streptozotocin injection. However, it was able to decrease cholesterol and triglycerides and prevent damage on pancreatic islets morphology. Additionally, morphological alterations such as alveolar septa loss, inflammatory infiltrate and fibrosis were seen in lung tissue of rats with DM, and treatment with CSE apparently reversed these histopathological findings. Thus, CSE, treatment reduced the lipid profile and restored the lung architecture of diabetic animals by a mechanism independent of glycemia and which might be associated with the reduction of the damage on the pancreatic islets.
C1 [de Medeiros, Tessio David; Meira Taveira, Karinna Verissimo; da Graca Azevedo Abreu, Bento Joao; da Silva Farias, Naisandra Bezerra; de Paula Medeiros, Karina Carla] Univ Fed Rio Grande do Norte, Biosci Ctr, Dept Morphol, Natal, RN, Brazil.
   [Pereira, Annyelly Tavares; Bortolin, Raul Hernandes; de Rezende, Adriana Augusto] Univ Fed Rio Grande do Norte, Dept Clin & Toxicol Anal, Natal, RN, Brazil.
   [da Silva, Flavio Santos] Fed Rural Univ Semiarid Reg, Dept Hlth Sci, Mossora, Brazil.
   [Barbosa Filho, Jose Maria] Univ Fed Paraiba, Lab Pharmaceut Tecnol, Joao Pessoa, Paraiba, Brazil.
C3 Universidade Federal do Rio Grande do Norte; Universidade Federal do Rio
   Grande do Norte; Universidade Federal Rural do Semi-Arido (UFERSA);
   Universidade Federal da Paraiba
RP Medeiros, KCD (corresponding author), Univ Fed Rio Grande do Norte, Biosci Ctr, Dept Morphol, Natal, RN, Brazil.
EM karinapm@yahoo.com
RI Santos, Alberdan/AAY-7861-2020; Bortolin, Raul/O-2277-2016; Abreu,
   Bento/E-2607-2015; Barbosa Filho, Jose Maria/B-3951-2010; REZENDE,
   ADRIANA/L-4170-2018
OI Barbosa Filho, Jose Maria/0000-0002-9567-4096; Abreu, Bento
   Joao/0000-0001-8010-806X; Bortolin, Raul Hernandes/0000-0003-3424-3281;
   REZENDE, ADRIANA/0000-0003-2452-4047
FU Conselho Nacional de Desenvolvimento Cientifico e Tecnologico [CNPq
   -14/2010]; Fundacao de Amparo a Pesquisa do Estado do Rio Grande do
   Norte [FAPERN-PPP-3]
FX We thank Maria de Socorro M. Amarantes, Melyna S. Souto and Maria de
   Lourdes Freitas (Department of Morphology, CB, Federal University of Rio
   Grande do Norte) for expert assistance in histology. This work was
   supported by Conselho Nacional de Desenvolvimento Cientifico e
   Tecnologico (CNPq -14/2010) and Fundacao de Amparo a Pesquisa do Estado
   do Rio Grande do Norte (FAPERN-PPP-3).
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NR 50
TC 3
Z9 3
U1 0
U2 3
PU UNIV SAO PAULO, CONJUNTO QUIMICAS
PI SAO PAULO
PA SERVICO PUBLICACOES E CIRCULACAO, CAIXA POSTAL 66083, SAO PAULO, 00000,
   BRAZIL
SN 1984-8250
EI 2175-9790
J9 BRAZ J PHARM SCI
JI Braz. J. Pharm. Sci.
PY 2020
VL 56
AR e17374
DI 10.1590/s2175-97902019000417374
PG 9
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA KX0JT
UT WOS:000521570300001
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Ge, XW
   Xu, C
   Liu, YL
   Zhu, K
   Zeng, HY
   Su, J
   Huang, J
   Ji, Y
   Tan, YS
   Hou, YY
AF Ge, Xiaowen
   Xu, Chen
   Liu, Yalan
   Zhu, Kai
   Zeng, Haiying
   Su, Jieakesu
   Huang, Jie
   Ji, Yuan
   Tan, Yunshan
   Hou, Yingyong
TI Complement activation in the arteries of patients with severe
   atherosclerosis
SO INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY
LA English
DT Article
DE Complement; atherosclerosis; C3b/iC3b; MAC; hypertension;
   hypertriglyceridemia
ID ESTROGEN PLUS PROGESTIN; REGULATOR CD59 PROTECTS;
   CORONARY-HEART-DISEASE; SMOOTH-MUSCLE-CELLS; MYOCARDIAL-INFARCTION;
   SHEAR-STRESS; ATHEROGENIC LIPOPROTEINS; POSTMENOPAUSAL WOMEN; METABOLIC
   SYNDROME; CIGARETTE-SMOKE
AB Background: Excessive complement activation plays an important role in the pathogenesis of atherosclerosis (AS). We therefore wanted to investigate whether complement is activated in areas of AS by detecting the deposition of C3b/iC3b and membrane attack complex (MAC). We also analyzed the relationships between C3b/iC3b and MAC levels and the clinicopathological features of patients with AS. Methods: The sample comprised 79 patients who had been diagnosed with AS. Their levels of C3b/iC3b and MAC deposition were evaluated by immunohistochemistry (IHC). The results were translated into scores, and the patients' clinical features were recorded. Results: Compared with normal arteries, significantly greater deposits of C3b/iC3b and MAC were found in AS arteries. In the group with more C3b/iC3b deposition, the ratio of patients with hypertension was higher. Moreover, in the group with more MAC deposition, the ratio of patients with hypertriglyceridemia was higher. Conclusions: The finding of C3b/iC3b and MAC deposition in atherosclerotic arteries points to the activation of complement. Greater amounts of C3b/iC3b and MAC deposition imply excessive complement activation, which can lead to the development of AS. Hypertension and hypertriglyceridemia may, respectively, contribute to the activation of complement C3 or the formation of MAC.
C1 [Ge, Xiaowen; Xu, Chen; Liu, Yalan; Zeng, Haiying; Su, Jieakesu; Huang, Jie; Ji, Yuan; Tan, Yunshan; Hou, Yingyong] Fudan Univ, Zhongshan Hosp, Dept Pathol, 180 Fenglin Rd, Shanghai 200032, Peoples R China.
   [Zhu, Kai] Fudan Univ, Zhongshan Hosp, Dept Cardiovasc Surg, Shanghai, Peoples R China.
C3 Fudan University; Fudan University
RP Hou, YY (corresponding author), Fudan Univ, Zhongshan Hosp, Dept Pathol, 180 Fenglin Rd, Shanghai 200032, Peoples R China.
EM hou.yingyong@zs-hospital.sh.cn
RI hou, ying/MSV-8661-2025
FU Shanghai Municipal Commission of Health and Family Planning for Young
   Scientists [20134y102]; National Natural Science Foundation of China
   [81402570]; Zhongshan Hospital for Excellent Young Scientists
   [2015ZSYXQN01]
FX This work was supported by Shanghai Municipal Commission of Health and
   Family Planning for Young Scientists (grant no. 20134y102), National
   Natural Science Foundation of China (grant no. 81402570), and Zhongshan
   Hospital for Excellent Young Scientists (grant no. 2015ZSYXQN01) to
   Xiaowen Ge.
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NR 49
TC 11
Z9 12
U1 0
U2 10
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 1936-2625
J9 INT J CLIN EXP PATHO
JI Int. J. Clin. Exp. Pathol.
PY 2018
VL 11
IS 1
BP 1
EP 9
PG 9
WC Oncology; Pathology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Pathology
GA FY4HF
UT WOS:000426782300001
PM 31938082
DA 2025-06-11
ER

PT J
AU Sampath, C
   Rashid, MR
   Sang, SM
   Ahmedna, M
AF Sampath, Chethan
   Rashid, Muhammed Raihan
   Sang, Shengmin
   Ahmedna, Mohamed
TI Green tea epigallocatechin 3-gallate alleviates hyperglycemia and
   reduces advanced glycation end products via nrf2 pathway in mice with
   high fat diet-induced obesity
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Article
DE Diabetes; Advance glycation end-products; Epigallocatechin gallate;
   Nrf2; Dicarbonyl stress; RAGE
ID MOLECULAR-MECHANISMS; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   GENE-EXPRESSION; ADIPOSE-TISSUE; GALLATE;
   (-)-EPIGALLOCATECHIN-3-GALLATE; SUPPLEMENTATION; METHYLGLYOXAL;
   POLYPHENOL
AB Epigallocatechin 3-gallate (EGCG) from green tea may reduce plasma glucose and alleviate complications of diabetes by attenuating advanced glycation end products (AGEs) formation. We hypothesized that EGCG would mitigate AGEs formation via activating the nuclear factor erythroid-2-related-factor-2 (Nrf2) pathway in a mouse model of high fat diet-induced obesity. Dietary EGCG was tested in C57BL/6 mice that were placed on a high-fat diet with or without ECGC for 17 weeks and compared to a control group placed on low-fat diet for the same period. Weight gain and fasting blood glucose were measured throughout the study duration. Supplementation of high fat diet with dietary EGCG significantly reduced weight gain, plasma glucose, insulin level, liver and kidney weight. EGCG administration also decreased the levels of AGEs in both plasma and liver while inhibiting the receptor for AGE (RAGE) expression of, activating Nrf2 and enhancing GSH/GSSG ratio compared to mice on high fat diet without added EGCG. This study demonstrated that EGCG has the potential to help control hyperglycemia, reduce weight, and alleviate diabetes complications. (C) 2016 Elsevier Masson SAS. All rights reserved.
C1 [Sampath, Chethan; Rashid, Muhammed Raihan; Ahmedna, Mohamed] Qatar Univ, Dept Human Nutr, Coll Hlth Sci, Doha 2713, Qatar.
   [Sang, Shengmin] North Carolina Agr & Tech State Univ, Ctr Excellence Postharvest Technol, Lab Funct Foods & Human Hlth, North Carolina Res Campus,500 Laureate Way, Kannapolis, NC 28081 USA.
C3 Qatar University; University of North Carolina; North Carolina A&T State
   University
RP Ahmedna, M (corresponding author), Qatar Univ, Coll Hlth Sci, POB 2713, Doha, Qatar.
EM ahmedna@qu.edu.qa
RI Sang, Shengmin/AFK-9982-2022; Sampath, Chethan/AAX-7521-2020
FU NPRP from the Qatar National Research Fund [NPRP 5-2203-063]
FX This research was made possible by NPRP grant #NPRP 5-2203-063 from the
   Qatar National Research Fund (a member of Qatar Foundation). The
   statements made herein are solely the responsibility of the authors. The
   authors would also like to thank Dr. Hamda Al-Naemi, Dr. Anthony James
   and all the staff at Laboratory Animal Research Center, Qatar University
   for their constant support during the animal experiments.
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NR 43
TC 87
Z9 91
U1 0
U2 88
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD MAR
PY 2017
VL 87
BP 73
EP 81
DI 10.1016/j.biopha.2016.12.082
PG 9
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA EM7XM
UT WOS:000395525600008
PM 28040599
DA 2025-06-11
ER

PT J
AU Suzuki, T
   Pervin, M
   Goto, S
   Isemura, M
   Nakamura, Y
AF Suzuki, Takuji
   Pervin, Monira
   Goto, Shingo
   Isemura, Mamoru
   Nakamura, Yoriyuki
TI Beneficial Effects of Tea and the Green Tea Catechin
   Epigallocatechin-3-gallate on Obesity
SO MOLECULES
LA English
DT Review
DE green tea; catechin; obesity; adipogenesis; lipogenesis; lipolysis; AMPK
ID HIGH-FAT DIET; METABOLIC SYNDROME; BLACK TEA; INSULIN-RESISTANCE;
   BODY-COMPOSITION; BLOOD-PRESSURE; IN-VITRO; (-)-EPIGALLOCATECHIN
   GALLATE; POSTMENOPAUSAL WOMEN; OXIDATIVE STRESS
AB Green tea has been shown to have beneficial effects against cancer, obesity, atherosclerosis, diabetes, bacterial and viral infections, and dental caries. The catechin (-)-epigallocatechin-3-gallate (EGCG) has shown the highest biological activity among green tea catechins (GTCs) in most of the studies. While several epidemiological studies have shown the beneficial effects of tea and GTCs on obesity, some studies have failed to do this. In addition, a large number of interventional clinical studies have shown these favorable effects, and cellular and animal experiments have supported those findings, and revealed the underlying anti-obesity mechanisms. One of the mechanisms is enhanced cellular production of reactive oxygen species, which is mediated through the pro-oxidant action of EGCG, leading to the activation of adenosine monophosphate-activated protein kinase, which suppresses gene and protein expression of enzymes and transcription factors involved in adipogenesis and lipogenesis, and stimulates those involved in lipolysis. Recently, scientific evidence supporting the beneficial anti-obesity effects of green tea and GTCs has been increasing. However, future investigations are still required to clarify the reasons for the inconsistent results reported in the human studies; to achieve this, careful adjustment of confounding factors will be required.
C1 [Suzuki, Takuji] Yamagata Univ, Fac Educ Art & Sci, Yamagata 9908560, Japan.
   [Pervin, Monira; Isemura, Mamoru; Nakamura, Yoriyuki] Univ Shizuoka, Tea Sci Ctr, Shizuoka 4228526, Japan.
   [Goto, Shingo] Univ Shizuoka, Grad Sch Nutr & Environm Sci, Shizuoka 4228526, Japan.
   [Goto, Shingo] NARO, Inst Fruit Tree & Tea Sci, Div Citrus Res, Okitsunakacho, Shizuoka 4240292, Japan.
C3 Yamagata University; University of Shizuoka; University of Shizuoka;
   National Agriculture & Food Research Organization - Japan
RP Isemura, M (corresponding author), Univ Shizuoka, Tea Sci Ctr, Shizuoka 4228526, Japan.
EM taksuzuk@e.yamagata-u.ac.jp; monira689@yahoo.com; gotos@affrc.go.jp;
   isemura@u-shizuoka-ken.ac.jp; yori.naka222@u-shizuoka-ken.ac.jp
RI Goto, Shingo/AAU-4777-2021
OI Goto, Shingo/0000-0002-2298-7016; Suzuki, Takuji/0000-0002-7257-6792
FU Ministry of Agriculture, Forestries and Fisheries of Japan
FX This study was supported in part by a 2016 Grant-in-Aid for
   Establishment of Tea Production Districts from the Ministry of
   Agriculture, Forestries and Fisheries of Japan.
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NR 80
TC 151
Z9 158
U1 6
U2 112
PU MDPI AG
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1420-3049
J9 MOLECULES
JI Molecules
PD OCT
PY 2016
VL 21
IS 10
AR 1305
DI 10.3390/molecules21101305
PG 13
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA EE9AL
UT WOS:000389917900042
PM 27689985
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Skop, V
   Trnovská, J
   Oliyarnyk, O
   Marková, I
   Malínská, H
   Kazdová, L
   Zídek, V
   Landa, V
   Mlejnek, P
   Simáková, M
   Kudela, M
   Pravenec, M
   Silhavy, J
AF Skop, V.
   Trnovska, J.
   Oliyarnyk, O.
   Markova, I.
   Malinska, H.
   Kazdova, L.
   Zidek, V.
   Landa, V.
   Mlejnek, P.
   Simakova, M.
   Kudela, M.
   Pravenec, M.
   Silhavy, J.
TI Hepatotoxic Effects of Fenofibrate in Spontaneously Hypertensive Rats
   Expressing Human C-Reactive Protein
SO PHYSIOLOGICAL RESEARCH
LA English
DT Article
DE Fenofibrate; Rosuvastatin; C-reactive protein; Transgenic; Spontaneously
   hypertensive rat; Inflammation; Hepatotoxic
ID PROLIFERATOR-ACTIVATED-RECEPTOR; GENE-EXPRESSION; INFLAMMATION; LIVER;
   ROSUVASTATIN; ACCUMULATION; METAANALYSIS; THERAPY; INJURY; STATIN
AB Dyslipidemia and inflammation play an important role in the pathogenesis of cardiovascular and liver disease. Fenofibrate has a well-known efficacy to reduce cholesterol and triglycerides. Combination with statins can ameliorate hypolipidemic and anti-inflammatory effects of fibrates. In the current study, we tested the anti-inflammatory and metabolic effects of fenofibrate alone and in combination with rosuvastatin in a model of inflammation and metabolic syndrome, using spontaneously hypertensive rats expressing the human C-reactive protein transgene (SHR-CRP transgenic rats). SHR-CRP rats treated with fenofibrate alone (100 mg/kg body weight) or in combination with rosuvastatin (20 mg/kg body weight) vs. SHR-CRP untreated controls showed increased levels of proinflammatory marker IL6, increased concentrations of ALT, AST and ALP, increased oxidative stress in the liver and necrotic changes of the liver. In addition, SHR-CRP rats treated with fenofibrate, or with fenofibrate combined with rosuvastatin vs. untreated controls, exhibited increased serum triglycerides and reduced HDL cholesterol, as well as reduced hepatic triglyceride, cholesterol and glycogen concentrations. These findings suggest that in the presence of high levels of human CRP, fenofibrate can induce liver damage even in combination with rosuvastatin. Accordingly, these results caution against the possible hepatotoxic effects of fenofibrate in patients with high levels of CRP.
C1 [Skop, V.; Trnovska, J.; Oliyarnyk, O.; Markova, I.; Malinska, H.; Kazdova, L.] Inst Clin & Expt Med, Ctr Med Expt, Prague, Czech Republic.
   [Zidek, V.; Landa, V.; Mlejnek, P.; Simakova, M.; Pravenec, M.; Silhavy, J.] Czech Acad Sci, Inst Physiol, Videnska 1083, Prague 14220 4, Czech Republic.
   [Kudela, M.] Masaryk Hosp, Dept Forens Med, Usti Nad Labem, Czech Republic.
C3 Institute for Clinical & Experimental Medicine (IKEM); Czech Academy of
   Sciences; Institute of Physiology of the Czech Academy of Sciences;
   Masaryk Hospital
RP Silhavy, J (corresponding author), Czech Acad Sci, Inst Physiol, Videnska 1083, Prague 14220 4, Czech Republic.
EM jsilhavy@biomed.cas.cz
RI Oliyarnyk, Olena/Q-6380-2019; Silhavy, Jan/B-5292-2014; Simakova,
   Miroslava/R-5367-2019; Skop, Vojtech/LBI-2231-2024; Mlejnek,
   Petr/C-2305-2012; Pravenec, Michal/B-1666-2012
OI Skop, Vojtech/0000-0002-4685-4429; Trnovska,
   Jaroslava/0000-0001-6468-8244; Mlejnek, Petr/0000-0002-4218-8983;
   Markova, Irena/0000-0002-4331-7636; Pravenec,
   Michal/0000-0001-9197-5871; Simakova, Miroslava/0000-0003-1468-5832;
   Kudela, Milan/0000-0002-5927-2698; Oliyarnyk, Olena/0000-0002-4912-6187
FU Ministry of Health of the Czech Republic [NT/14325-3/2013]
FX This work was supported by grant NT/14325-3/2013 from the Ministry of
   Health of the Czech Republic.
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NR 23
TC 12
Z9 12
U1 0
U2 2
PU ACAD SCIENCES CZECH REPUBLIC, INST PHYSIOLOGY
PI PRAGUE 4
PA VIDENSKA 1083, PRAGUE 4 142 20, CZECH REPUBLIC
SN 0862-8408
EI 1802-9973
J9 PHYSIOL RES
JI Physiol. Res.
PY 2016
VL 65
IS 6
BP 891
EP 899
DI 10.33549/physiolres.933304
PG 9
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA EJ3NR
UT WOS:000393119400001
PM 27539098
OA gold
DA 2025-06-11
ER

PT J
AU Johns, M
   Fyalka, R
   Shea, JA
   Neumann, WL
   Rausaria, S
   Msengi, EN
   Imani-Nejad, M
   Zollars, H
   McPherson, T
   Schober, J
   Wooten, J
   Kwon, G
AF Johns, Michael
   Fyalka, Robert
   Shea, Jennifer A.
   Neumann, William L.
   Rausaria, Smita
   Msengi, Eliwaza Naomi
   Imani-Nejad, Maryam
   Zollars, Harry
   McPherson, Timothy
   Schober, Joseph
   Wooten, Joshua
   Kwon, Guim
TI SR-135, a peroxynitrite decomposing catalyst, enhances β-cell function
   and survival in B6D2F1 mice fed a high fat diet
SO ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
LA English
DT Article
DE Diabetes; Peroxynitrite; Pancreatic beta-cell; Insulin; Nitrotyrosine;
   Apoptosis
ID NITRIC-OXIDE SYNTHASE; INSULIN-RESISTANCE; TYROSINE NITRATION; OXIDATIVE
   STRESS; LIPID-PEROXIDATION; METABOLIC SYNDROME; DIABETES-MELLITUS; NOD
   MICE; OBESITY; INFLAMMATION
AB Peroxynitrite has been implicated in beta-cell dysfunction and insulin resistance in obesity. Chemical catalysts that destroy peroxynitrite, therefore, may have therapeutic value for treating type 2 diabetes. To this end, we have recently demonstrated that Mn(III) bis(hydroxyphenyl)-dipyrromethene complexes, SR-135 and its analogs, can effectively catalyze the decomposition of peroxynitrite in vitro and in vivo through a 2-electron mechanism (Rausaria et al., 2011). To study the effects of SR-135 on glucose homeostasis in obesity, B6D2F1 mice were fed with a high fat-diet (HFD) for 12 weeks and treated with vehicle, SR-135 (5 mg/kg), or a control drug SRB for 2 weeks. SR-135 significantly reduced fasting blood glucose and insulin levels, and enhanced glucose tolerance as compared to HFD control, vehicle or SRB. SR-135 also enhanced glucose-stimulated insulin secretion based on ex vivo studies. Moreover, SR-135 increased insulin content, restored islet architecture, decreased islet size, and reduced tyrosine nitration and apoptosis. These results suggest that a peroxynitrite decomposing catalyst enhances beta-cell function and survival under nutrient overload. (C) 2015 Elsevier Inc. All rights reserved.
C1 [Neumann, William L.; Rausaria, Smita; Msengi, Eliwaza Naomi; Imani-Nejad, Maryam; Zollars, Harry; McPherson, Timothy; Schober, Joseph; Kwon, Guim] So Illinois Univ, Sch Pharm, Edwardsville, IL 62026 USA.
   [Johns, Michael; Fyalka, Robert; Shea, Jennifer A.] So Illinois Univ, Dept Biol Sci, Edwardsville, IL 62026 USA.
   [Wooten, Joshua] So Illinois Univ, Dept Kinesiol & Hlth Educ, Edwardsville, IL 62026 USA.
C3 Southern Illinois University System; Southern Illinois University
   Edwardsville; Southern Illinois University System; Southern Illinois
   University Edwardsville; Southern Illinois University System; Southern
   Illinois University Edwardsville
RP Kwon, G (corresponding author), So Illinois Univ, Sch Pharm, Dept Pharmaceut Sci, 220 Univ Pk, Edwardsville, IL 62026 USA.
EM gkwon@siue.edu
RI Wooten, Joshua/K-9703-2017
OI McPherson, Timothy/0000-0001-6779-1028
FU NIH [1R15DK094142-01A1]; SIUE internal grants; NIH NIAMS [RC1AR058231]
FX This work was supported by NIH Grants 1R15DK094142-01A1 (GK) and NIH
   NIAMS RC1AR058231 (WLN) and SIUE internal grants (GK and WLN).
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NR 48
TC 7
Z9 8
U1 1
U2 6
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0003-9861
EI 1096-0384
J9 ARCH BIOCHEM BIOPHYS
JI Arch. Biochem. Biophys.
PD JUL
PY 2015
VL 577
BP 49
EP 59
DI 10.1016/j.abb.2015.04.005
PG 11
WC Biochemistry & Molecular Biology; Biophysics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics
GA CK3MJ
UT WOS:000356119900005
PM 25935364
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Jain, SK
   Huning, L
   Micinski, D
AF Jain, Sushil K.
   Huning, Laura
   Micinski, David
TI Hydrogen Sulfide Upregulates Glutamate-Cysteine Ligase Catalytic
   Subunit, Glutamate-Cysteine Ligase Modifier Subunit, and Glutathione and
   Inhibits Interleukin-1β Secretion in Monocytes Exposed to High Glucose
   Levels
SO METABOLIC SYNDROME AND RELATED DISORDERS
LA English
DT Article
ID MEMBRANE LIPID-PEROXIDATION; CARDIOVASCULAR-DISEASE; DIABETIC-PATIENTS;
   OXIDATIVE STRESS; ATHEROSCLEROSIS; INFLAMMATION; BLOOD; HOMOCYSTEINE;
   HEMOGLOBIN; ANTAGONIST
AB Glutathione (GSH) deficiency and interleukin-1 beta (IL-1 beta) upregulation are linked to the progression of vascular inflammation and atherosclerosis. The consumption of sulfide-rich vegetables is known to lower the risk of atherosclerosis. This study examined the hypothesis that hydrogen sulfide (H2S) upregulates the glutamate-cysteine ligase catalytic subunit (GCLC) and GSH and inhibits IL-1 beta in a monocyte cell model. U937 monocytes were supplemented with H2S (0-12.5 mu M) for 2 hr and then exposed to a control or high glucose (HG, 25 mM) for 22 hr. Levels of GCLC and glutamate-cysteine ligase modifier subunit (GCLM) expression were determined by western blotting and GSH using high-performance liquid chromatography (HPLC), and IL-1 beta using enzyme-linked immunoassay (ELISA). H2S significantly (P < 0.05) upregulated expression of GCLC and GCLM, and formation of GSH, and inhibited IL-1 beta secretion in controls and HG-treated monocytes. This is the first demonstration of H2S upregulation of GCLC and GSH and inhibition of IL-1 beta levels, which may be what mediates the beneficial effects of H2S-rich compounds in mitigating the pathogenesis of metabolic syndrome and atherosclerosis.
C1 [Jain, Sushil K.; Huning, Laura; Micinski, David] LSU Hlth Sci Ctr, Dept Pediat, Shreveport, LA 71130 USA.
C3 Louisiana State University System; Louisiana State University Health
   Sciences Center at Shreveport
RP Jain, SK (corresponding author), LSU Hlth Sci Ctr, Dept Pediat, POB 33932,1501 Kings Highway, Shreveport, LA 71130 USA.
EM sjain@lsuhsc.edu
RI Micinski, David/IRZ-8236-2023
OI Micinski, David/0009-0003-6371-625X; Jain, Sushil/0000-0002-9574-0436
FU National Institute of Diabetes and Digestive and Kidney Diseases
   (NIDDK); Office of Dietary Supplements of the National Institutes of
   Health [RO1 DK 072433]; Malcolm Feist Endowed Chair in Diabetes
FX S.K.J. is supported by grants from National Institute of Diabetes and
   Digestive and Kidney Diseases (NIDDK) and the Office of Dietary
   Supplements of the National Institutes of Health (RO1 DK 072433) and the
   Malcolm Feist Endowed Chair in Diabetes. The authors thank Ms. Georgia
   Morgan for excellent editing of this manuscript.
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NR 25
TC 28
Z9 32
U1 0
U2 4
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-4196
EI 1557-8518
J9 METAB SYNDR RELAT D
JI Metab. Syndr. Relat. Disord.
PD JUN
PY 2014
VL 12
IS 5
BP 299
EP 302
DI 10.1089/met.2014.0022
PG 4
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA AI9JV
UT WOS:000337249800008
PM 24665821
OA Green Published
DA 2025-06-11
ER

PT J
AU Gámez-Méndez, AM
   Vargas-Robles, H
   Arellano-Mendoza, M
   Cruz-Laguna, E
   Rios, A
   Escalante, B
AF Maria Gamez-Mendez, Ana
   Vargas-Robles, Hilda
   Arellano-Mendoza, Monica
   Cruz-Laguna, Erika
   Rios, Amelia
   Escalante, Bruno
TI Early stage of obesity potentiates nitric oxide reduction during the
   development of renal failure
SO JOURNAL OF NEPHROLOGY
LA English
DT Article
DE CKD; Nitric oxide; Obesity
ID ENDOTHELIAL DYSFUNCTION; FAT DIET; METABOLIC SYNDROME; MECHANISMS; RISK;
   SYNTHASE; DISEASE; KIDNEY; RESISTANCE; STRESS
AB Background Obesity is a serious health problem associated with the pathogenesis of various metabolic diseases. Nitric Oxide (NO) plays an important role in kidney function and altered NO levels have been associated with the pathogenesis of obesity. Therefore, we aimed to study whether an early stage of obesity contributes with progression of renal failure through further NO impairment.
   Methods Male C57BL/6 mice were fed with a high-fat diet (HFD) or a normal diet (ND) during 2 weeks. All mice underwent either sham surgery (sham) or 5/6 nephrectomy (Np). One group of HFD Np mice was treated with antioxidants plus L-arginine. Kidney damage parameters were assessed and eNOS metabolism was evaluated.
   Results Mice on a HFD increased body weight, eNOS protein and mRNA expression, and radical oxygen species (ROS). Urine nitrites excretion, urine volume, and plasma BH4 were decreased. In HFD mice, 5/6 Np further increased BH2 and urine protein concentration, ROS levels, and eNOS mRNA expression. The decrease in BH4 plasma levels and urine nitrites excretion was accentuated. NO synthesis stimulation with the antioxidants + L-arginine treatment prevented all these changes.
   Conclusions The early changes in NO metabolism are associated with an early stage of obesity. This effect on NO potentiates kidney damage development.
C1 [Maria Gamez-Mendez, Ana; Vargas-Robles, Hilda; Arellano-Mendoza, Monica; Cruz-Laguna, Erika; Rios, Amelia; Escalante, Bruno] CINVESTAV Monterrey, Apodaca, Nuevo Leon, Mexico.
C3 CINVESTAV - Centro de Investigacion y de Estudios Avanzados del
   Instituto Politecnico Nacional
RP Escalante, B (corresponding author), CINVESTAV Monterrey, Apodaca, Nuevo Leon, Mexico.
EM arios@cinvestav.mx; bescalan@cinvestav.mx
RI Rios, Antonio/L-3870-2017
OI Gamez-Mendez, Ana Maria/0000-0003-0638-9988; Rios,
   Amelia/0000-0002-5328-118X
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NR 35
TC 13
Z9 14
U1 0
U2 4
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1121-8428
EI 1724-6059
J9 J NEPHROL
JI J. Nephrol.
PD JUN
PY 2014
VL 27
IS 3
BP 281
EP 287
DI 10.1007/s40620-013-0029-9
PG 7
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA AH3LI
UT WOS:000336024500008
PM 24446346
DA 2025-06-11
ER

PT J
AU Bruce-Keller, AJ
   Keller, JN
   Morrison, CD
AF Bruce-Keller, Annadora J.
   Keller, Jeffrey N.
   Morrison, Christopher D.
TI Obesity and vulnerability of the CNS
SO BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
LA English
DT Review
DE Age; Cognition; Dementia; High fat diet; Oxidative stress
ID BODY-MASS INDEX; INDEPENDENT RISK-FACTOR; TRAUMATIC BRAIN-INJURY;
   SATURATED-FAT DIET; NF-KAPPA-B; INSULIN-RESISTANCE; COGNITIVE FUNCTION;
   METABOLIC SYNDROME; LIFE-SPAN; MYOCARDIAL-INFARCTION
AB The incidence of obesity is increasing worldwide, and is especially pronounced in developed western countries. While the consequences of obesity on metabolic and cardiovascular Physiology are well established, epidemiological and experimental data are beginning to establish that the central nervous system (CNS) may also be detrimentally affected by obesity and obesity-induced metabolic dysfunction. In particular, data show that obesity in human populations is associated with cognitive decline and enhanced vulnerability to brain injury, while experimental studies in animal models confirm a profile of heightened vulnerability and decreased cognitive function. This review will describe findings from human and animal studies to summarize current understanding of how obesity affects the brain. Furthermore, studies aimed at identifying key elements of body-brain dialog will be discussed to assess how various metabolic and adipose-related signals could adversely affect the CNS. Overall, data suggest that obesity-induced alterations in metabolism may significantly synergize with age to impair brain function and accelerate age-related diseases of the nervous system. Thus, enhanced understanding of the effects of obesity and obesity-related metabolic dysfunction on the brain are especially critical as increasing numbers of obese individuals approach advanced age. (C) 2008 Elsevier B.V. All rights reserved.
C1 [Bruce-Keller, Annadora J.; Keller, Jeffrey N.; Morrison, Christopher D.] Louisiana State Univ, Pennington Biomed Res Ctr, Inflammat & Neurodegenerat Lab, Baton Rouge, LA 70808 USA.
C3 Louisiana State University System; Louisiana State University;
   Pennington Biomedical Research Center
RP Bruce-Keller, AJ (corresponding author), Louisiana State Univ, Pennington Biomed Res Ctr, Inflammat & Neurodegenerat Lab, 6400 Perkins Rd, Baton Rouge, LA 70808 USA.
EM annadora.bruce-keller@pbrc.edu
RI Keller, Jeffrey/N-1975-2017; Bruce-Keller, Annadora/N-1954-2017;
   Morrison, Christopher/A-6093-2010
OI Morrison, Christopher/0000-0002-5492-102X; keller,
   jeffrey/0000-0002-9892-7423
FU NIA NIH HHS [P01 AG005119] Funding Source: Medline; NINDS NIH HHS [R01
   NS046267] Funding Source: Medline
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NR 118
TC 157
Z9 178
U1 0
U2 15
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0925-4439
EI 1879-260X
J9 BBA-MOL BASIS DIS
JI Biochim. Biophys. Acta-Mol. Basis Dis.
PD MAY
PY 2009
VL 1792
IS 5
SI SI
BP 395
EP 400
DI 10.1016/j.bbadis.2008.10.004
PG 6
WC Biochemistry & Molecular Biology; Biophysics; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Biochemistry & Molecular Biology; Biophysics; Cell Biology
GA 444CC
UT WOS:000265956700002
PM 18992327
OA Green Submitted, Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Boondam, Y
   Saefoong, C
   Niltup, N
   Monteil, A
   Kitphati, W
AF Boondam, Yingrak
   Saefoong, Chaianan
   Niltup, Natjanan
   Monteil, Arnaud
   Kitphati, Worawan
TI The Cognitive Restoration Effects of Resveratrol: Insight Molecular
   through Behavioral Studies in Various Cognitive Impairment Models
SO ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE
LA English
DT Review
DE resveratrol; cognition; memory; ROS; inflammation
ID OXIDATIVE STRESS; MITOCHONDRIAL BIOGENESIS; METABOLIC SYNDROME; MEMORY
   IMPAIRMENT; DOWN-REGULATION; SPATIAL MEMORY; AUTOPHAGY; SIRT1;
   DYSFUNCTION; AGE
AB Cognition is essential for daily activities and progressively deteriorates with age due to various factors leading to cognitive decline. This decline often begins with memory impairment and advances to broader cognitive dysfunctions. Resveratrol (RES), a natural phenolic compound found in red wine, has garnered significant attention for its potential to prevent cognitive decline. This review aims to synthesize the latest preclinical data on the cognitive restorative effects of RES. We highlight RES activities from cellular mechanisms to behavioral outcomes. Evidence from various cognitive impairment models demonstrates that RES exerts neuroprotective effects through multiple mechanisms, including anti-inflammatory, antioxidative, anti-apoptotic, and neurotrophic actions, all of which contribute to cognitive enhancement in behavioral studies. Despite the established role of RES in mitigating memory decline, our review identifies a critical gap in behavioral studies regarding cognitive flexibility. Further research in this domain is recommended. Additionally, species-specific pharmacokinetic differences may account for the inconsistencies between preclinical and clinical outcomes, particularly in rats and humans. We propose that formulations designed to delay gut metabolism through enterohepatic circulation could enhance the translational potential of RES. Furthermore, long-term studies are needed to determine the optimal dose capable of maximizing health benefits without raising toxicity during chronic use.
C1 [Boondam, Yingrak; Kitphati, Worawan] Mahidol Univ, Fac Pharm, Dept Physiol, Bangkok 10400, Thailand.
   [Boondam, Yingrak; Kitphati, Worawan] Mahidol Univ, Fac Pharm, Ctr Biopharmaceut Sci Hlth Ageing, Bangkok 10400, Thailand.
   [Saefoong, Chaianan; Niltup, Natjanan] Mahidol Univ, Fac Pharm, Bangkok 10400, Thailand.
   [Monteil, Arnaud] Mahidol Univ, Siriraj Hosp, Fac Med, Dept Physiol, Bangkok 10400, Thailand.
   [Monteil, Arnaud] Univ Montpellier, Inst Funct Genom, CNRS, INSERM, F-34094 Montpellier, France.
C3 Mahidol University; Mahidol University; Mahidol University; Mahidol
   University; Institut National de la Sante et de la Recherche Medicale
   (Inserm); Universite de Montpellier; Centre National de la Recherche
   Scientifique (CNRS)
RP Kitphati, W (corresponding author), Mahidol Univ, Fac Pharm, Dept Physiol, Bangkok 10400, Thailand.; Kitphati, W (corresponding author), Mahidol Univ, Fac Pharm, Ctr Biopharmaceut Sci Hlth Ageing, Bangkok 10400, Thailand.
EM Worawan.kit@mahidol.ac.th
OI Boondam, Yingrak/0000-0002-8538-9152
FU Faculty of Pharmacy, Mahidol University, Thailand
FX We are grateful for the support from the Faculty of Pharmacy, Mahidol
   University, Thailand. We also thank Assistant Professor Dr. Wichit
   Nosoongnoen for his advice in the pharmacokinetic study interpretation.
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NR 136
TC 0
Z9 0
U1 3
U2 3
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
EI 2575-9108
J9 ACS PHARMACOL TRANSL
JI ACS Pharmacol. Transl. Sci.
PD OCT 10
PY 2024
VL 7
IS 11
BP 3334
EP 3357
DI 10.1021/acsptsci.4c00373
EA OCT 2024
PG 24
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Emerging Sources Citation Index (ESCI)
SC Pharmacology & Pharmacy
GA L6F3Q
UT WOS:001336906700001
PM 39539271
OA hybrid
DA 2025-06-11
ER

PT J
AU Wang, H
   Shan, CL
   Guo, GJ
   Ning, DL
   Miao, FJ
AF Wang, Hao
   Shan, Chunlan
   Guo, Gangjun
   Ning, Delu
   Miao, Fujun
TI Therapeutic potential of palmitoleic acid in non-alcoholic fatty liver
   disease: Targeting ferroptosis and lipid metabolism disorders
SO INTERNATIONAL IMMUNOPHARMACOLOGY
LA English
DT Article
DE Palmitoleic acid; Non-alcoholic fatty liver disease; Ferroptosis; Lipid
   metabolism
ID INSULIN-RESISTANCE; EXPRESSION
AB Background: Non-alcoholic fatty liver disease (NAFLD) is a metabolic syndrome associated with obesity and type 2 diabetes mellitus. Currently, there are no effective drugs to treat NAFLD. Palmitoleic acid (PA) has demonstrated therapeutic potential in managing various metabolic diseases and inflammation. Although ferroptosis is known to play a critical role in the NAFLD development, it remains unclear whether PA can alleviate NAFLD by inhibiting ferroptosis. Methods: Thirty C57BL/6 mice were divided into three groups: standard diet, high-fat diet (HFD), and HFD with PA. The experiment lasted 16 weeks. Results: PA alleviated liver injury, hepatitis, and dyslipidemia in HFD-induced NAFLD mice. It improved insulin resistance, downregulated genes and proteins related to fat synthesis, and upregulated genes and proteins linked to lipolysis and fat oxidation. Mechanistically, bioinformatics enrichment revealed the involvement of ferroptosis in NAFLD. PA mitigated oxidative stress and reduced liver iron content in NAFLD. It downregulated acyl-CoA synthetase long-chain family member 4 (ACSL4) expression while upregulating glutathione peroxidase 4 (GPX4) and solute carrier family 7 member 11 (SLC7A11) expression, thereby inhibiting ferroptosis. Conclusion: PA exerts a protective effect against liver lipotoxicity by inhibiting lipid metabolism-mediated ferroptosis. These findings provide new insights into preventive and therapeutic strategies for the pathological processes of NAFLD.
C1 [Ning, Delu; Miao, Fujun] Yunnan Woody Oilseed Technol Innovat Ctr, Yunnan Acad Forestry & Grassland, Kunming 650204, Peoples R China.
   [Wang, Hao] Yunnan Agr Univ, Coll Food Sci & Technol, Kunming 650201, Peoples R China.
   [Shan, Chunlan] Guizhou Univ, Coll Anim Sci, Guiyang 550025, Peoples R China.
   [Guo, Gangjun] Yunnan Inst Trop Crops, Jinghong 666100, Peoples R China.
C3 Yunnan Agricultural University; Guizhou University
RP Miao, FJ (corresponding author), Yunnan Acad Foresty & Grassland, Lanan Rd 2, Kunming 650000, Peoples R China.
EM miaofujun@yeah.net
OI Miao, Fujun/0000-0001-6202-3310; Wang, hao/0000-0002-1555-7261
FU Science and Technology Major Program of Yunnan Province, China
   [202202AE090006]
FX This work was financially supported by the Science and Technology Major
   Program of Yunnan Province, China (Grant No. 202202AE090006) . We thank
   Home for Researchers editorial team ( www.home-for-researchers.com ) for
   language editing service.
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Z9 6
U1 3
U2 7
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1567-5769
EI 1878-1705
J9 INT IMMUNOPHARMACOL
JI Int. Immunopharmacol.
PD DEC 5
PY 2024
VL 142
AR 113025
DI 10.1016/j.intimp.2024.113025
EA SEP 2024
PN A
PG 12
WC Immunology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Pharmacology & Pharmacy
GA F8Z6V
UT WOS:001312635400001
PM 39243559
DA 2025-06-11
ER

PT J
AU Gallo, G
   Savoia, C
AF Gallo, Giovanna
   Savoia, Carmine
TI New Insights into Endothelial Dysfunction in Cardiometabolic Diseases:
   Potential Mechanisms and Clinical Implications
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE endothelium; diabetes; metabolic syndrome; endothelial dysregulation;
   cardiometabolic diseases
ID CORONARY-ARTERY-DISEASE; C-REACTIVE PROTEIN; ADHESION MOLECULES;
   CARDIOVASCULAR-DISEASE; HEART-DISEASE; NITRIC-OXIDE; RISK;
   ATHEROSCLEROSIS; ACTIVATION; COVID-19
AB The endothelium is a monocellular layer covering the inner surface of blood vessels. It maintains vascular homeostasis regulating vascular tone and permeability and exerts anti-inflammatory, antioxidant, anti-proliferative, and anti-thrombotic functions. When the endothelium is exposed to detrimental stimuli including hyperglycemia, hyperlipidemia, and neurohormonal imbalance, different biological pathways are activated leading to oxidative stress, endothelial dysfunction, increased secretion of adipokines, cytokines, endothelin-1, and fibroblast growth factor, and reduced nitric oxide production, leading eventually to a loss of integrity. Endothelial dysfunction has emerged as a hallmark of dysmetabolic vascular impairment and contributes to detrimental effects on cardiac metabolism and diastolic dysfunction, and to the development of cardiovascular diseases including heart failure. Different biomarkers of endothelial dysfunction have been proposed to predict cardiovascular diseases in order to identify microvascular and macrovascular damage and the development of atherosclerosis, particularly in metabolic disorders. Endothelial dysfunction also plays an important role in the development of severe COVID-19 and cardiovascular complications in dysmetabolic patients after SARS-CoV-2 infection. In this review, we will discuss the biological mechanisms involved in endothelial dysregulation in the context of cardiometabolic diseases as well as the available and promising biomarkers of endothelial dysfunction in clinical practice.
C1 [Gallo, Giovanna; Savoia, Carmine] Sapienza Univ Rome, St Andrea Hosp, Fac Med & Psychol, Clin & Mol Med Dept, Via Grottarossa 1035-1039, I-00189 Rome, Italy.
C3 Sapienza University Rome; Azienda Ospedaliera Sant'Andrea
RP Savoia, C (corresponding author), Sapienza Univ Rome, St Andrea Hosp, Fac Med & Psychol, Clin & Mol Med Dept, Via Grottarossa 1035-1039, I-00189 Rome, Italy.
EM giovanna.gallo@uniroma1.it; carmine.savoia@uniroma1.it
RI Gallo, Giovanna/AAE-6249-2021
OI Savoia, Carmine/0000-0002-2296-1959; Gallo, Giovanna/0000-0003-4845-117X
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NR 97
TC 30
Z9 32
U1 5
U2 7
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD MAR
PY 2024
VL 25
IS 5
AR 2973
DI 10.3390/ijms25052973
PG 14
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA KV3B7
UT WOS:001182688500001
PM 38474219
OA Green Published, gold
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Davis, C
   Huggins, CE
   Kleve, S
   Leung, GKW
   Bonham, MP
AF Davis, Corinne
   Huggins, Catherine E.
   Kleve, Sue
   Leung, Gloria K. W.
   Bonham, Maxine P.
TI Conceptualizing weight management for night shift workers: A
   mixed-methods systematic review
SO OBESITY REVIEWS
LA English
DT Review
DE diet; exercise; obesity; work schedule
ID PHYSICAL-ACTIVITY; RISK-FACTORS; CARDIOVASCULAR RISK; METABOLIC
   SYNDROME; HEALTH; OBESITY; SLEEP; INTERVENTIONS; BARRIERS; BEHAVIOR
AB Shift workers have an increased risk of obesity and metabolic conditions. This mixed-methods systematic literature review on night shift workers aimed to: (1) identify barriers/enablers of weight management; (2) examine effectiveness of weight management interventions; and (3) determine whether interventions addressed enablers/barriers. Six databases were searched, articles screened by title/abstract, followed by full-text review, and quality assessment. Eligible qualitative studies documented experiences of behaviors related to weight change. Eligible quantitative studies were behavior change interventions with weight/body mass index outcomes. A thematic synthesis was undertaken for qualitative studies using the social-ecological model (SEM). Interventions were synthesized narratively including: weight/body composition change; components mapped by behavior change taxonomy; and SEM. A synthesis was undertaken to identify if interventions addressed perceived enablers/barriers. Eight qualitative (n = 169 participants) and 12 quantitative studies (n = 1142 participants) were included. Barriers predominated discussions: intrapersonal (time, fatigue, stress); interpersonal (work routines/cultural norms); organizational (fatigue, lack of: routine, healthy food options, breaks/predictable work); community (lack of healthy food options). The primary outcome for interventions was not weight loss and most did not address many identified enablers/barriers. One intervention reported a clinically significant weight loss result. Weight loss interventions that address barriers/enablers at multiple SEM levels are needed.
C1 [Davis, Corinne; Huggins, Catherine E.; Kleve, Sue; Leung, Gloria K. W.; Bonham, Maxine P.] Monash Univ, Fac Med Nursing & Hlth Sci, Dept Nutr Dietet & Food, Notting Hill, Vic, Australia.
   [Huggins, Catherine E.] Deakin Univ, Inst Hlth Transformat, Global Ctr Prevent Hlth & Nutr, Sch Hlth & Social Dev,Fac Hlth, Geelong, Australia.
   [Davis, Corinne] Monash Univ, Fac Med Nursing & Hlth Sci, Dept Nutr Dietet & Food, BASE,Level 1, 264 Ferntree Gully Rd, Notting Hill 3168, Australia.
C3 Monash University; Deakin University; Monash University
RP Davis, C (corresponding author), Monash Univ, Fac Med Nursing & Hlth Sci, Dept Nutr Dietet & Food, BASE,Level 1, 264 Ferntree Gully Rd, Notting Hill 3168, Australia.
EM corinne.davis1@monash.edu
RI Bonham, Maxine/I-2266-2014; Leung, Gloria/JCD-6261-2023
OI Huggins, Catherine/0000-0003-3929-7756
FU National Health and Medical Research Council (NHMRC) project grant ID
   1159762. CD was supported by the Australian Government RTP Scholarship
   and the King and Amy Oapos;Malley Trust Scholarship. Open access
   publishing facilitated by Monash University, as p [1159762]; National
   Health and Medical Research Council (NHMRC); Australian Government RTP
   Scholarship; King and Amy Oapos;Malley Trust Scholarship; Monash
   University, as part of the Wiley - Monash University agreement via the
   Council of Australian University Librarians
FX National Health and Medical Research Council (NHMRC) project grant ID
   1159762. CD was supported by the Australian Government RTP Scholarship
   and the King and Amy O & apos;Malley Trust Scholarship. Open access
   publishing facilitated by Monash University, as part of the Wiley -
   Monash University agreement via the Council of Australian University
   Librarians.
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NR 80
TC 2
Z9 2
U1 3
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1467-7881
EI 1467-789X
J9 OBES REV
JI Obes. Rev.
PD FEB
PY 2024
VL 25
IS 2
DI 10.1111/obr.13659
EA NOV 2023
PG 18
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA EL7B6
UT WOS:001104590300001
PM 37985937
OA hybrid
DA 2025-06-11
ER

PT J
AU Abé, C
   Liberg, B
   Klahn, AL
   Petrovic, P
   Landén, M
AF Abe, Christoph
   Liberg, Benny
   Klahn, Anna Luisa
   Petrovic, Predrag
   Landen, Mikael
TI Mania-related effects on structural brain changes in bipolar disorder -
   a narrative review of the evidence
SO MOLECULAR PSYCHIATRY
LA English
DT Review
ID VOXEL-BASED MORPHOMETRY; GREY-MATTER VOLUME; GRAY-MATTER;
   CEREBROSPINAL-FLUID; CORTICAL THICKNESS; LITHIUM TREATMENT; GENETIC
   RISK; METABOLIC SYNDROME; SURFACE-AREA; I DISORDER
AB Cross-sectional neuroimaging studies show that bipolar disorder is associated with structural brain abnormalities, predominantly observed in prefrontal and temporal cortex, cingulate gyrus, and subcortical regions. However, longitudinal studies are needed to elucidate whether these abnormalities presage disease onset or are consequences of disease processes, and to identify potential contributing factors. Here, we narratively review and summarize longitudinal structural magnetic resonance imaging studies that relate imaging outcomes to manic episodes. First, we conclude that longitudinal brain imaging studies suggest an association of bipolar disorder with aberrant brain changes, including both deviant decreases and increases in morphometric measures. Second, we conclude that manic episodes have been related to accelerated cortical volume and thickness decreases, with the most consistent findings occurring in prefrontal brain areas. Importantly, evidence also suggests that in contrast to healthy controls, who in general show age-related cortical decline, brain metrics remain stable or increase during euthymic periods in bipolar disorder patients, potentially reflecting structural recovering mechanisms. The findings stress the importance of preventing manic episodes. We further propose a model of prefrontal cortical trajectories in relation to the occurrence of manic episodes. Finally, we discuss potential mechanisms at play, remaining limitations, and future directions.
C1 [Abe, Christoph; Liberg, Benny; Petrovic, Predrag] Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden.
   [Abe, Christoph] Quantify Res, Stockholm, Sweden.
   [Klahn, Anna Luisa; Landen, Mikael] Univ Gothenburg, Sahlgrenska Acad, Inst Neurosci & Physiol, Dept Psychiat & Neurochem, Gothenburg, Sweden.
   [Klahn, Anna Luisa] Univ Gothenburg, Dept Chem & Mol Biol, Gothenburg, Sweden.
   [Petrovic, Predrag] Karolinska Inst, Ctr Cognit & Computat Neuropsychiat, Stockholm, Sweden.
   [Petrovic, Predrag] Karolinska Inst, Ctr Psychiat Res, Stockholm, Sweden.
   [Landen, Mikael] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.
C3 Karolinska Institutet; University of Gothenburg; University of
   Gothenburg; Karolinska Institutet; Karolinska Institutet; Karolinska
   Institutet
RP Landén, M (corresponding author), Univ Gothenburg, Sahlgrenska Acad, Inst Neurosci & Physiol, Dept Psychiat & Neurochem, Gothenburg, Sweden.; Landén, M (corresponding author), Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.
EM Mikael.Landen@neuro.gu.se
RI Klahn, Luisa/LDG-1147-2024; Landen, Mikael/AAD-7917-2020; Petrovic,
   Predrag/AAS-6736-2020
OI Abe, Christoph/0000-0002-1680-8480; Klahn, Luisa/0000-0002-9189-6687;
   Petrovic, Predrag/0000-0002-5536-945X
FU Swedish Medical Research Council [202201643]; Swedish Brain foundation
   [FO20200261]; Wenner-Gren foundation [SSv20190008]; Swedish government;
   ALF-agreement [ALFGBG- 965444]
FX ML is funded by the Swedish Medical Research Council (2022-01643), the
   Swedish Brain foundation (FO2020-0261), the Wenner-Gren foundation
   (SSv2019-0008), and by the Swedish state under the agreement between the
   Swedish government and the county councils, the ALF-agreement (ALFGBG-
   965444).
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NR 103
TC 16
Z9 17
U1 2
U2 5
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 1359-4184
EI 1476-5578
J9 MOL PSYCHIATR
JI Mol. Psychiatr.
PD JUL
PY 2023
VL 28
IS 7
BP 2674
EP 2682
DI 10.1038/s41380-023-02073-4
EA MAY 2023
PG 9
WC Biochemistry & Molecular Biology; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Neurosciences & Neurology; Psychiatry
GA X5UQ7
UT WOS:000982808600001
PM 37147390
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Ghosh, N
   Chacko, L
   Bhattacharya, H
   Vallamkondu, J
   Nag, S
   Dey, A
   Karmakar, T
   Reddy, PH
   Kandimalla, R
   Dewanjee, S
AF Ghosh, Nilanjan
   Chacko, Leena
   Bhattacharya, Hiranmoy
   Vallamkondu, Jayalakshmi
   Nag, Sagnik
   Dey, Abhijit
   Karmakar, Tanushree
   Reddy, P. Hemachandra
   Kandimalla, Ramesh
   Dewanjee, Saikat
TI Exploring the Complex Relationship between Diabetes and Cardiovascular
   Complications: Understanding Diabetic Cardiomyopathy and Promising
   Therapies
SO BIOMEDICINES
LA English
DT Review
DE diabetes mellitus; diabetic cardiomyopathy; heart failure;
   hyperglycemia; insulin resistance; lipotoxicity
ID AUTONOMIC NERVOUS-SYSTEM; HEART-FAILURE; SGLT2 INHIBITORS; OXIDATIVE
   STRESS; MECHANISMS; DISEASE; GLP-1; OBESITY; SACUBITRIL/VALSARTAN;
   PATHOPHYSIOLOGY
AB Diabetes mellitus (DM) and cardiovascular complications are two unmet medical emergencies that can occur together. The rising incidence of heart failure in diabetic populations, in addition to apparent coronary heart disease, ischemia, and hypertension-related complications, has created a more challenging situation. Diabetes, as a predominant cardio-renal metabolic syndrome, is related to severe vascular risk factors, and it underlies various complex pathophysiological pathways at the metabolic and molecular level that progress and converge toward the development of diabetic cardiomyopathy (DCM). DCM involves several downstream cascades that cause structural and functional alterations of the diabetic heart, such as diastolic dysfunction progressing into systolic dysfunction, cardiomyocyte hypertrophy, myocardial fibrosis, and subsequent heart failure over time. The effects of glucagon-like peptide-1 (GLP-1) analogues and sodium-glucose cotransporter-2 (SGLT-2) inhibitors on cardiovascular (CV) outcomes in diabetes have shown promising results, including improved contractile bioenergetics and significant cardiovascular benefits. The purpose of this article is to highlight the various pathophysiological, metabolic, and molecular pathways that contribute to the development of DCM and its significant effects on cardiac morphology and functioning. Additionally, this article will discuss the potential therapies that may be available in the future.
C1 [Ghosh, Nilanjan] Jadavpur Univ, Dept Pharmaceut Technol, Mol Pharmacol Res Lab, Kolkata 700032, India.
   [Chacko, Leena] Meso Scale Discovery, BioAnalyt Lab, Rockville, MD 20850 USA.
   [Bhattacharya, Hiranmoy; Dewanjee, Saikat] Jadavpur Univ, Dept Pharmaceut Technol, Adv Pharmacognosy Res Lab, Kolkata 700032, India.
   [Vallamkondu, Jayalakshmi] Natl Inst Technol, Dept Phys, Warangal 506004, India.
   [Nag, Sagnik] Vellore Inst Technol VIT, Sch Biosci & Technol, Dept Biotechnol, Tiruvalam Rd, Vellore 632014, India.
   [Dey, Abhijit] Presidency Univ, Dept Life Sci, Kolkata 700073, India.
   [Karmakar, Tanushree] Dr BC Roy Coll Pharm & Allied Hlth Sci, Durgapur 713206, India.
   [Reddy, P. Hemachandra] Texas Tech Univ Hlth Sci Ctr, Lubbock, TX 79430 USA.
   [Kandimalla, Ramesh] Kakatiya Med Coll, Dept Biochem, Warangal 506007, India.
C3 Jadavpur University; Jadavpur University; National Institute of
   Technology (NIT System); National Institute of Technology Warangal;
   Vellore Institute of Technology (VIT); VIT Vellore; Presidency
   University, Kolkata; Texas Tech University System; Texas Tech University
   Health Sciences Center Lubbock; Kakatiya Medical College
RP Dewanjee, S (corresponding author), Jadavpur Univ, Dept Pharmaceut Technol, Adv Pharmacognosy Res Lab, Kolkata 700032, India.; Kandimalla, R (corresponding author), Kakatiya Med Coll, Dept Biochem, Warangal 506007, India.
EM ramesh.kandimalla@gmail.com; saikat.dewanjee@jadavpuruniversity.in
RI Dey, Abhijit/AAG-2439-2020; Vallamkondu, Jayalakshmi/B-1830-2017;
   Chacko, Leena/HOA-8650-2023; Dewanjee, Saikat/U-9778-2017; Kandimalla,
   Ramesh/O-4047-2017; NAG, SAGNIK/JDV-9463-2023
OI Reddy, P. Hemachandra/0000-0002-9560-9948; Kandimalla,
   Ramesh/0000-0002-3313-4393; Chacko, Leena/0000-0002-0383-6925;
   Bhattacharya, Hiranmoy/0000-0001-7596-3520; Dey,
   Abhijit/0000-0002-5750-0802; Dewanjee, Saikat/0000-0001-9085-4226; NAG,
   SAGNIK/0000-0002-6814-5471; Ghosh, Nilanjan/0000-0003-0520-0952
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NR 179
TC 24
Z9 25
U1 1
U2 11
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2227-9059
J9 BIOMEDICINES
JI Biomedicines
PD APR
PY 2023
VL 11
IS 4
AR 1126
DI 10.3390/biomedicines11041126
PG 30
WC Biochemistry & Molecular Biology; Medicine, Research & Experimental;
   Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Research & Experimental Medicine;
   Pharmacology & Pharmacy
GA E9RV8
UT WOS:000978836900001
PM 37189744
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Ghanemi, A
   Yoshioka, M
   St-Amand, J
AF Ghanemi, Abdelaziz
   Yoshioka, Mayumi
   St-Amand, Jonny
TI Secreted Protein Acidic and Rich in Cysteine (SPARC)-Mediated
   Exercise Effects: Illustrative Molecular Pathways against Various
   Diseases
SO DISEASES
LA English
DT Article
DE secreted protein acidic and rich in cysteine (SPARC); exercise;
   molecular pathways; diseases
ID SKELETAL-MUSCLE; OXIDATIVE STRESS; PHAS-I; METABOLIC SYNDROME;
   GENE-EXPRESSION; AGING MUSCLE; SPARC; PHOSPHORYLATION; INFLAMMATION;
   INSULIN
AB The strong benefits of exercise, in addition to the development of both the therapeutic applications of physical activity and molecular biology tools, means that it has become very important to explore the underlying molecular patterns linking exercise and its induced phenotypic changes. Within this context, secreted protein acidic and rich in cysteine (SPARC) has been characterized as an exercise-induced protein that would mediate and induce some important effects of exercise. Herein, we suggest some underlying pathways to explain such SPARC-induced exercise-like effects. Such mechanistic mapping would not only allow us to understand the molecular processes of exercise and SPARC effects but would also highlight the potential to develop novel molecular therapies. These therapies would be based on mimicking the exercise benefits via either introducing SPARC or pharmacologically targeting the SPARC-related pathways to produce exercise-like effects. This is of a particular importance for those who do not have the ability to perform the required physical activity due to disabilities or diseases. The main objective of this work is to highlight selected potential therapeutic applications deriving from SPARC properties that have been reported in various publications.
C1 [Ghanemi, Abdelaziz; St-Amand, Jonny] Laval Univ, Fac Med, Dept Mol Med, Quebec City, PQ G1V 0A6, Canada.
   [Ghanemi, Abdelaziz; Yoshioka, Mayumi; St-Amand, Jonny] Univ Laval, Funct Genom Lab, Endocrinol & Nephrol Axis, CHU Quebec,Res Ctr, Quebec City, PQ G1V 4G2, Canada.
C3 Laval University; Laval University; Laval University Hospital
RP St-Amand, J (corresponding author), Laval Univ, Fac Med, Dept Mol Med, Quebec City, PQ G1V 0A6, Canada.; St-Amand, J (corresponding author), Univ Laval, Funct Genom Lab, Endocrinol & Nephrol Axis, CHU Quebec,Res Ctr, Quebec City, PQ G1V 4G2, Canada.
EM jonny.st-amand@crchudequebec.ulaval.ca
RI GHANEMI, Abdelaziz/GWM-6575-2022; GHANEMI, Abdelaziz/D-5254-2014
OI St-Amand, Jonny/0000-0002-2595-6127; GHANEMI,
   Abdelaziz/0000-0001-9676-1119
FU Merit Scholarship Program for foreign students from the Ministry of
   Education and Higher Education of Quebec, Canada; Fonds de recherche du
   Quebec-Sante (FRQS), Quebec, Canada; la Caisse Desjardins de
   l'Universite Laval, Quebec, Canada
FX Abdelaziz Ghanemi received a scholarship under the Merit Scholarship
   Program for foreign students from the Ministry of Education and Higher
   Education of Quebec, Canada. The Fonds de recherche du Quebec-Nature et
   technologies (FRQNT) is responsible for managing the program (Bourses
   d'excellence pour etudiants etrangers du Ministere de l'Education et de
   l'Enseignement superieur du Quebec, Le Fonds de recherche du
   Quebec-Nature et technologies (FRQNT) est responsable de la gestion du
   programme). Abdelaziz Ghanemi received the scholarship "Bourse
   Tremplin-Stage en milieu de pratique" (Internship scholarship) from the
   Fonds de recherche du Quebec-Sante (FRQS), Quebec, Canada. Abdelaziz
   Ghanemi received the scholarship "Inspirational journey" ("Un parcours
   inspirant") from la Caisse Desjardins de l'Universite Laval, Quebec,
   Canada.
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NR 110
TC 4
Z9 7
U1 0
U2 0
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2079-9721
J9 DISEASES-BASEL
JI Diseases
PD MAR
PY 2023
VL 11
IS 1
AR 33
DI 10.3390/diseases11010033
PG 11
WC Medicine, Research & Experimental
WE Emerging Sources Citation Index (ESCI)
SC Research & Experimental Medicine
GA A9EN4
UT WOS:000958078400001
PM 36810547
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Wanjari, UR
   Mukherjee, AG
   Gopalakrishnan, AV
   Murali, R
   Dey, A
   Vellingiri, B
   Ganesan, R
AF Wanjari, Uddesh Ramesh
   Mukherjee, Anirban Goutam
   Gopalakrishnan, Abilash Valsala
   Murali, Reshma
   Dey, Abhijit
   Vellingiri, Balachandar
   Ganesan, Raja
TI Role of Metabolism and Metabolic Pathways in Prostate Cancer
SO METABOLITES
LA English
DT Review
DE PCa; MetS; metabolism; androgen; implication
ID NF-KAPPA-B; ANDROGEN RECEPTOR; OXIDATIVE-STRESS; HIGH-GRADE;
   GLUTAMINE-METABOLISM; LIPID-METABOLISM; PHOSPHOGLYCERATE KINASE;
   TRANSCRIPTIONAL PROGRAM; INDUCED PHOSPHORYLATION; INTRATUMORAL ANDROGENS
AB Prostate cancer (PCa) is the common cause of death in men. The pathophysiological factors contributing to PCa are not well known. PCa cells gain a protective mechanism via abnormal lipid signaling and metabolism. PCa cells modify their metabolism in response to an excessive intake of nutrients to facilitate advancement. Metabolic syndrome (MetS) is inextricably linked to the carcinogenic progression of PCa, which heightens the severity of the disease. It is hypothesized that changes in the metabolism of the mitochondria contribute to the onset of PCa. The studies of particular alterations in the progress of PCa are best accomplished by examining the metabolome of prostate tissue. Due to the inconsistent findings written initially, additional epidemiological research is required to identify whether or not MetS is an aspect of PCa. There is a correlation between several risk factors and the progression of PCa, one of which is MetS. The metabolic symbiosis between PCa cells and the tumor milieu and how this type of crosstalk may aid in the development of PCa is portrayed in this work. This review focuses on in-depth analysis and evaluation of the metabolic changes that occur within PCa, and also aims to assess the effect of metabolic abnormalities on the aggressiveness status and metabolism of PCa.
C1 [Wanjari, Uddesh Ramesh; Mukherjee, Anirban Goutam; Gopalakrishnan, Abilash Valsala; Murali, Reshma] Vellore Inst Technol VIT, Sch Biosci & Technol, Dept Biomed Sci, Vellore 632014, India.
   [Dey, Abhijit] Presidency Univ, Dept Life Sci, Kolkata 700073, India.
   [Vellingiri, Balachandar] Cent Univ Punjab CUPB, Sch Basic Sci, Dept Zool, Stem Cell & Regenerat Med Translat Res, Bathinda 151401, India.
   [Ganesan, Raja] Hallym Univ, Inst Liver & Digest Dis, Coll Med, Chunchon 24252, South Korea.
C3 Vellore Institute of Technology (VIT); VIT Vellore; Presidency
   University, Kolkata; Central University of Punjab; Hallym University
RP Gopalakrishnan, AV (corresponding author), Vellore Inst Technol VIT, Sch Biosci & Technol, Dept Biomed Sci, Vellore 632014, India.; Ganesan, R (corresponding author), Hallym Univ, Inst Liver & Digest Dis, Coll Med, Chunchon 24252, South Korea.
EM abilash.vg@vit.ac.in; vraja.ganesan@gmail.com
RI Ganesan, Raja/AAW-3703-2021; Dey, Abhijit/AAG-2439-2020; Vellingiri,
   Balachandar/MDT-9619-2025; Valsala Gopalakrishnan, Abilash/C-1482-2019;
   Mukherjee, Anirban Goutam/ABB-7233-2021
OI Valsala Gopalakrishnan, Abilash/0000-0003-0780-0492; Vellingiri,
   Balachandar/0000-0002-3043-6839; Ganesan, Raja/0000-0003-3060-6217; Dey,
   Abhijit/0000-0002-5750-0802; Mukherjee, Anirban
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NR 245
TC 10
Z9 10
U1 0
U2 6
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2218-1989
J9 METABOLITES
JI Metabolites
PD FEB
PY 2023
VL 13
IS 2
AR 183
DI 10.3390/metabo13020183
PG 20
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 9K0UW
UT WOS:000940591200001
PM 36837801
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Cestonaro, LV
   Macedo, SMD
   Piton, YV
   Garcia, SC
   Arbo, MD
AF Cestonaro, Larissa Vivan
   Macedo, Sandra Manoela Dias
   Piton, Yasmin Vendrusculo
   Garcia, Solange Cristina
   Arbo, Marcelo Dutra
TI Toxic effects of pesticides on cellular and humoral immunity: an
   overview
SO IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY
LA English
DT Review
DE Pesticide; immunotoxicity; immune system; immune cells; immune
   alteration; in vitro; animal; human
ID SHORT-TERM EXPOSURE; OXIDATIVE STRESS; OCCUPATIONAL-EXPOSURE;
   IMMUNOLOGICAL PARAMETERS; DEVELOPMENTAL TOXICITY; ENVIRONMENTAL
   EXPOSURE; ENDOCRINE DISRUPTION; IN-VIVO; IMMUNOTOXICITY; ZEBRAFISH
AB People are exposed to pesticides through food, drinking water, and the environment. These compounds are associated with several disorders, such as inflammatory diseases, rheumatoid arthritis, cancer, and a condition related to metabolic syndrome. The immunotoxicants or immunotoxic compounds can cause a wide variety of effects on immune function, altering humoral immunity and cell-mediated immunity, resulting in adverse effects to the body. Here, immune system disorders are highlighted because they are closely linked to multiple organs, including the nervous, endocrine, reproductive, cardiovascular, and respiratory systems, leading to transient or permanent changes. Therefore, this study reviewed the mechanisms involved in the immunotoxicity of fungicides, herbicides, and insecticides in cells, animals, and humans in the past 11 years. According to the studies analyzed, the pesticides interfere with innate and adaptive immune functions, but the effects observed mainly on cellular and humoral immunity were highlighted. These compounds affected specific immune cells, causing apoptosis, changes in factor nuclear kappa B (NF-kappa B) expression, pro-inflammatory factors interleukin 6 (IL-6), interleukin 8 (IL-8), interferon-gamma (IFN-gamma), chemokines (CXCL-c1c), and anti-inflammatory factor, such as interleukin 10 (IL-10). To verify the threats of these compounds, new evaluations with immunotoxicological biomarkers are necessary.
C1 [Cestonaro, Larissa Vivan; Piton, Yasmin Vendrusculo; Garcia, Solange Cristina; Arbo, Marcelo Dutra] Univ Fed Rio Grande Sul UFRGS, Fac Farm, Dept Anal, Lab Toxicol, Porto Alegre, RS, Brazil.
   [Cestonaro, Larissa Vivan; Garcia, Solange Cristina; Arbo, Marcelo Dutra] Univ Fed Rio Grande Sul UFRGS, Fac Farm, Programa Posgrad Ciencias Farmaceut, Porto Alegre, RS, Brazil.
   [Macedo, Sandra Manoela Dias] Univ Fed Ciencias Saude Porto Alegre UFCSPA, Dept Farmacociencias, Porto Alegre, RS, Brazil.
C3 Universidade Federal do Rio Grande do Sul; Universidade Federal do Rio
   Grande do Sul; Universidade Federal de Ciencias da Saude de Porto Alegre
RP Arbo, MD (corresponding author), Rua Sao Luis 150, BR-90620170 Porto Alegre, RS, Brazil.
EM marcelo.arbo@ufrgs.br
RI Vivan Cestonaro, Larissa/I-3183-2016; Garcia, Solange/J-3039-2013
OI Vivan Cestonaro, Larissa/0000-0001-9500-7042; Garcia,
   Solange/0000-0003-3752-5751
FU Fundacao de Amparo ~a Pesquisa do Estado do Rio Grande do Sul (FAPERGS);
   Conselho Nacional de Desenvolvimento Cient~ifico e Tecnol~ogico (CNPq)
FX The authors would like to thank the support of Fundacao de Amparo ~a
   Pesquisa do Estado do Rio Grande do Sul (FAPERGS) and Conselho Nacional
   de Desenvolvimento Cient~ifico e Tecnol~ogico (CNPq).
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NR 116
TC 23
Z9 23
U1 10
U2 37
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0892-3973
EI 1532-2513
J9 IMMUNOPHARM IMMUNOT
JI Immunopharmacol. Immunotoxicol.
PD NOV 2
PY 2022
VL 44
IS 6
BP 816
EP 831
DI 10.1080/08923973.2022.2096466
EA JUL 2022
PG 16
WC Immunology; Pharmacology & Pharmacy; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Pharmacology & Pharmacy; Toxicology
GA 6Z3UV
UT WOS:000823592200001
PM 35770924
DA 2025-06-11
ER

PT J
AU Aranaz, P
   Peña, A
   Vettorazzi, A
   Fabra, MJ
   Martínez-Abad, A
   López-Rubio, A
   Pera, J
   Parladé, J
   Castellari, M
   Milagro, FI
   González-Navarro, CJ
AF Aranaz, Paula
   Pena, Adriana
   Vettorazzi, Ariane
   Fabra, Maria Jose
   Martinez-Abad, Antonio
   Lopez-Rubio, Amparo
   Pera, Joan
   Parlade, Javier
   Castellari, Massimo
   Milagro, Fermin, I
   Gonzalez-Navarro, Carlos J.
TI Grifola frondosa (Maitake) Extract Reduces Fat Accumulation and Improves
   Health Span in C. elegans through the DAF-16/FOXO and SKN-1/NRF2
   Signalling Pathways
SO NUTRIENTS
LA English
DT Article
DE bioactive compounds; nutraceutical fungi; obesity; metabolic syndrome;
   insulin; food ingredients
ID CAENORHABDITIS-ELEGANS; OXIDATIVE STRESS; ADIPOSE-TISSUE; SOS/UMU-TEST;
   FRUIT BODY; ANTIOXIDANT; OBESITY; POLYSACCHARIDES; RESISTANCE; MODEL
AB In recent years, food ingredients rich in bioactive compounds have emerged as candidates to prevent excess adiposity and other metabolic complications characteristic of obesity, such as low-grade inflammation and oxidative status. Among them, fungi have gained popularity for their high polysaccharide content and other bioactive components with beneficial activities. Here, we use the C. elegans model to investigate the potential activities of a Grifola frondosa extract (GE), together with the underlying mechanisms of action. Our study revealed that GE represents an important source of polysaccharides and phenolic compounds with in vitro antioxidant activity. Treatment with our GE extract, which was found to be nongenotoxic through a SOS/umu test, significantly reduced the fat content of C. elegans, decreased the production of intracellular ROS and aging-lipofuscin pigment, and increased the lifespan of nematodes. Gene expression and mutant analyses demonstrated that the in vivo anti-obesity and antioxidant activities of GE were mediated through the daf-2/daf-16 and skn-1/nrf-2 signalling pathways, respectively. Taken together, our results suggest that our GE extract could be considered a potential functional ingredient for the prevention of obesity-related disturbances.
C1 [Aranaz, Paula; Pena, Adriana; Milagro, Fermin, I; Gonzalez-Navarro, Carlos J.] Univ Navarra, Ctr Nutr Res, Pamplona 31008, Spain.
   [Aranaz, Paula; Milagro, Fermin, I] Navarra Inst Hlth Res IdiSNA, Pamplona 31008, Spain.
   [Vettorazzi, Ariane] Univ Navarra, Sch Pharm & Nutr, Dept Pharmacol & Toxicol, MITOX Res Grp, Pamplona 31008, Spain.
   [Fabra, Maria Jose; Martinez-Abad, Antonio; Lopez-Rubio, Amparo] Inst Agrochem & Food Technol IATA CSIC, Food Safety & Preservat Dept, Valencia 46980, Spain.
   [Fabra, Maria Jose; Martinez-Abad, Antonio; Lopez-Rubio, Amparo] Spanish Natl Res Council SusPlast CSIC, Interdisciplinary Platform Sustainable Plast Circ, Madrid 28006, Spain.
   [Pera, Joan; Parlade, Javier] IRTA, Inst Agr & Food Res & Technol IRTA, Cabrils Ctr, Ctra Cabrils Km 2, Barcelona 08348, Spain.
   [Castellari, Massimo] Inst Agr & Food Res & Technol IRTA, Finca Camps & Armet S-N, Monells 17121, Spain.
   [Milagro, Fermin, I] Inst Salud Carlos III, Ctr Invest Biomed Red Fisiopatol Obesidad & Nutr, Madrid 28029, Spain.
C3 University of Navarra; University of Navarra; University of Navarra;
   Consejo Superior de Investigaciones Cientificas (CSIC); IRTA; IRTA;
   Instituto de Salud Carlos III; CIBER - Centro de Investigacion Biomedica
   en Red; CIBEROBN
RP González-Navarro, CJ (corresponding author), Univ Navarra, Ctr Nutr Res, Pamplona 31008, Spain.
EM paranaz@unav.es; apenafuente@alumni.unav.es; avettora@unav.es;
   mjfabra@iata.csic.es; conaba@iata.csic.es; amparo.lopez@iata.csic.es;
   Joan.Pera@irta.cat; xavier.parlade@irta.cat;
   massimo.castellari@irta.cat; fmilagro@unav.es; cgnavarro@unav.es
RI Milagro, Fermin/F-2315-2015; González Navarro, Carlos
   Javier/G-6959-2015; Parlade, Javier/G-8304-2015; Fabra, María
   José/H-2831-2012; MARTINEZ-ABAD, Antonio/AAA-9900-2020; Lopez-Rubio,
   Amparo/H-2841-2012; Pera, Joan/B-8502-2008; Vettorazzi,
   Ariane/M-1405-2014
OI Lopez-Rubio, Amparo/0000-0001-6469-9402; Martinez-Abad,
   Antonio/0000-0002-6656-2917; Milagro, Fermin I./0000-0002-3228-9916;
   Aranaz, Paula/0000-0002-1282-0079; Pera, Joan/0000-0002-7252-8205;
   Vettorazzi, Ariane/0000-0001-9182-8417; Gonzalez-Navarro, Carlos
   Javier/0000-0002-3517-9077
FU CIEN project BIOPRO from "Centro para el Desarrollo Tecnologico
   Industrial" (CDTI), Ministry of Science and Innovation, Government of
   Spain
FX This work was performed with the financial support of the CIEN project
   BIOPRO from "Centro para el Desarrollo Tecnologico Industrial" (CDTI),
   Ministry of Science and Innovation, Government of Spain.
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NR 72
TC 15
Z9 15
U1 6
U2 61
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD NOV
PY 2021
VL 13
IS 11
AR 3968
DI 10.3390/nu13113968
PG 20
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA XE9ST
UT WOS:000723722200001
PM 34836223
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Mandal, S
AF Mandal, Sacira
TI The Determination of Total Serum Bilirubin Concentration in Type 2
   Diabetes patients
SO GLASNIK HEMICARA I TEHNOLOGA BOSNE I HERCEGOVINE
LA English
DT Article
DE Serum; Bilirubin; Type 2 diabetes
ID METABOLIC SYNDROME; OXIDATIVE STRESS; ASSOCIATION
AB Bilirubin represent a natural end-product of heme metabolism and is used as as a marker in diagnosis off hepatobiliary diseases. Recent studies demonstrated that serum bilirubin levels are related to the risk of Type 2 diabetes mellitus (T2D) development and subsequent complications. The aim of this study was to analyzed serum total bilirubin concentrations and its relationship with biochemical and clinical characteristics in T2D patients. Total of 109 participants were included in this study, 54 controls and 55 diabetic patients, both gender, while ages ranged from 35 to 70 years. Biochemical parameters were analyzed by standard IFCC methods while serum total bilirubin concentrations was determined by the method of Jendrassik/Grof. All analyses and measurements were provided by using the chemical analyzer VITROS 350. Results showed a significant difference in concentrations of glucose, glycated hemoglobin (HbA1c), lipid profile (total cholesterol, triglycerides, HDL cholesterol, LDL cholesterol) and bilirubin between T2D patients and controls (p<0.05). Also, significant association was found between bilirubin and glucose concentrations in two investigated populations (p<0.05). It appears that elevated concentration of bilirubin and biochemical characteristics are associated with the progression development of Type 2 diabetes and its related vascular complications. Therefore, total serum bilirubin concentrations could be used as potential T2D biomarker and therefore, as new therapeutic target.
C1 [Mandal, Sacira] Univ Sarajevo, Fac Pharm, Dept Nat Sci Pharm, Sarajevo, Bosnia & Herceg.
C3 University of Sarajevo
RP Mandal, S (corresponding author), Univ Sarajevo, Fac Pharm, Dept Nat Sci Pharm, Sarajevo, Bosnia & Herceg.
EM shakira.mandal@gmail.com
OI Mandal, Sacira/0000-0002-7736-7631
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NR 32
TC 2
Z9 2
U1 0
U2 3
PU UNIV SARAJEVO, FAC SCIENCE
PI SARAJEVO
PA ZMAJA OD BOSNE 33-35, SARAJEVO, BA 71000, BOSNIA & HERCEG
SN 0367-4444
EI 2232-7266
J9 GLAS HEMICARA TEHNOL
JI Glas. Hemicara Tehnol. Bosne Hercegovina
PD JUN
PY 2021
IS 56
BP 7
EP 12
DI 10.35666/2232-7266.2021.56.02
PG 6
WC Chemistry, Multidisciplinary
WE Emerging Sources Citation Index (ESCI)
SC Chemistry
GA XY3HK
UT WOS:000736867700003
OA gold
DA 2025-06-11
ER

PT J
AU Yang, Y
   Zhang, JL
   Zhou, Q
AF Yang, Yang
   Zhang, Jiu-liang
   Zhou, Qing
TI Targets and mechanisms of dietary anthocyanins to combat hyperglycemia
   and hyperuricemia: a comprehensive review
SO CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
LA English
DT Review
DE Diabetes; postprandial glycemia; insulin resistance; gout; anthocyanins;
   structure-activity relationship
ID PANCREATIC BETA-CELLS; SERUM URIC-ACID; DIPEPTIDYL PEPTIDASE IV;
   MONTMORENCY TART CHERRY; RICH BLACK-CURRANT; INSULIN-RESISTANCE;
   SWEET-POTATO; IN-VITRO; METABOLIC SYNDROME; XANTHINE-OXIDASE
AB Hyperglycemia and hyperuricemia are both metabolic disorders related to excessive amount of metabolites in blood, which are considered as high risk factors for the development of many chronic diseases. Enzymes, cells, tissues and organs, which are relevant to metabolism and excretion of glucose and UA, are usually regarded to be the targets in treatment of hyperglycemia and hyperuricemia. Several drugs have been commonly applied to combat hyperglycemia and hyperuricemia through various targets but with unignorable side effects. Anthocyanins have become promising alternatives against hyperglycemia and hyperuricemia because of their bio-activities with little side effects. Structurally different anthocyanins from berry fruits, cherries and purple sweet potato lead to the diverse functional activity and property. This review is aimed to illustrate the specific targets that are available for anthocyanins from berry fruits, cherries and purple sweet potato in hyperglycemia and hyperuricemia management, as well as discuss the structure-activity relationship, and the underlying mechanisms associated with intracellular signaling pathway, anti-oxidative stress and anti-inflammation. In addition, the relationship of hyperglycemia and hyperuricemia, and the possibly regulative role of anthocyanins against them, along with the effects of anthocyanins in clinical trial are mentioned.
C1 [Yang, Yang; Zhang, Jiu-liang] Huazhong Agr Univ, Coll Food Sci & Technol, 1 Shizishan St, Wuhan 430070, Hubei, Peoples R China.
   [Zhang, Jiu-liang] Minist Educ, Key Lab Environm Correlat Dietol, Wuhan, Peoples R China.
   [Zhou, Qing] Huazhong Univ Sci & Technol, Tongji Med Coll, Wuhan City Cent Hosp, Dept Pharm, Wuhan, Peoples R China.
C3 Huazhong Agricultural University; Ministry of Education - China;
   Huazhong University of Science & Technology
RP Zhang, JL; Zhou, Q (corresponding author), Huazhong Agr Univ, Coll Food Sci & Technol, 1 Shizishan St, Wuhan 430070, Hubei, Peoples R China.
EM zjl_ljz@mail.hzau.edu.cn; qingz_zqing@aliyun.com
RI Yang, Yuyi/N-5428-2015; , Jiuliang/ADF-2357-2022
OI Yang, Yang/0000-0001-5506-9396; , Jiuliang/0000-0002-1745-846X
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NR 193
TC 35
Z9 35
U1 6
U2 156
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1040-8398
EI 1549-7852
J9 CRIT REV FOOD SCI
JI Crit. Rev. Food Sci. Nutr.
PD FEB 21
PY 2022
VL 62
IS 4
BP 1119
EP 1143
DI 10.1080/10408398.2020.1835819
EA OCT 2020
PG 25
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA YO7UT
UT WOS:000579662300001
PM 33078617
DA 2025-06-11
ER

PT J
AU Wood, E
   Hein, S
   Heiss, C
   Williams, C
   Rodriguez-Mateos, A
AF Wood, Eleanor
   Hein, Sabine
   Heiss, Christian
   Williams, Claire
   Rodriguez-Mateos, Ana
TI Blueberries and cardiovascular disease prevention
SO FOOD & FUNCTION
LA English
DT Review
ID PERIPHERAL ARTERIAL DYSFUNCTION; BLOOD-PRESSURE; DOUBLE-BLIND; OXIDATIVE
   STRESS; METABOLIC SYNDROME; COMMON FOODS; RISK-FACTORS; STAGE
   1-HYPERTENSION; POSTMENOPAUSAL WOMEN; ANTHOCYANIN INTAKE
AB Blueberries are a rich source of (poly)phenols, particularly anthocyanins. Epidemiological studies indicate that anthocyanin-rich foods including blueberries are associated with a reduction in the risk of cardiovascular disease. These observational findings are supported by a number of randomized-controlled trials showing improvements in biomarkers of cardiovascular disease risk. The beneficial effects of blueberry (poly)phenols are particularly clear when measuring flow-mediated dilation over various timeframes and study populations. However, other outcomes are less clear, such as effects on blood pressure, arterial stiffness and blood lipid profile. This may be due to the heterogeneity existing in study designs, such as duration of the intervention, and the health status of participants. Longer-term RCTs using gold standard methods in relevant populations which can be translated to the general public are needed to clarify and strengthen the evidence available. While circulating phenolic blueberry metabolites have been linked with improvements in vascular function, the biological activities and mechanisms of action of individual metabolites and their interaction in vivo are still unknown. Evaluating the bioactivities of metabolites alone and together, and analysing their structure-activity relationship in well-designed and physiologically relevant experimental and human studies are needed to understand the mechanisms of how these metabolites affect vascular function.
C1 [Wood, Eleanor; Hein, Sabine; Rodriguez-Mateos, Ana] Kings Coll London, Fac Life Sci & Med, Sch Life Course Sci, Dept Nutr Sci, London, England.
   [Hein, Sabine; Williams, Claire] Univ Reading, Sch Psychol & Clin Language Sci, Reading, Berks, England.
   [Heiss, Christian] Univ Surrey, Fac Hlth & Med Sci, Guildford, Surrey, England.
   [Heiss, Christian] Surrey & Sussex Healthcare NHS Trust, Redhill, Surrey, England.
C3 University of London; King's College London; University of Reading;
   University of Surrey
RP Rodriguez-Mateos, A (corresponding author), Kings Coll London, Fac Life Sci & Med, Sch Life Course Sci, Dept Nutr Sci, London, England.
EM ana.rodriguez-mateos@kcl.ac.uk
RI Heiss, Christian/AAL-8582-2020; Rodriguez-Mateos, Ana/ABE-1560-2020
OI Williams, Claire/0000-0003-4452-671X; Rodriguez-Mateos,
   Ana/0000-0003-3242-402X; Heiss, Christian/0000-0002-3212-8995
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J9 FOOD FUNCT
JI Food Funct.
PD DEC 1
PY 2019
VL 10
IS 12
BP 7621
EP 7633
DI 10.1039/c9fo02291k
PG 13
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA KD1PE
UT WOS:000507643700001
PM 31776541
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Rabanipour, N
   Roohafza, H
   Feizi, A
   Tirani, SA
   Sarrafzadegan, N
AF Rabanipour, Najmeh
   Roohafza, Hamidreza
   Feizi, Awat
   Tirani, Shahnaz Amani
   Sarrafzadegan, Nizal
TI Association between shift work and obesity in a large sample of Iranian
   steel industry workers
SO ARHIV ZA HIGIJENU RADA I TOKSIKOLOGIJU-ARCHIVES OF INDUSTRIAL HYGIENE
   AND TOXICOLOGY
LA English
DT Article
DE abdominal obesity; BMI; general obesity; waist circumference;
   waist-to-hip ratio
ID METABOLIC SYNDROME; PHYSICAL-ACTIVITY; HEALTH; PREVALENCE; OVERWEIGHT
AB Obesity is associated with several chronic diseases, and previous research suggests that shift work could be associated with the risk of overweight and obesity, but the results remain inconclusive. Furthermore, only a few studies report related findings for industrial workforce with high job-related stress. The aim of this cross-sectional study was to see if such association exists in a large sample of 3063 industrial workers in a developing country. The sample was selected among 16,000 steel company workers through multistage cluster sampling. We took anthropometric measurements, including body mass index (BMI), waist circumference (WC), and waist-to-hip ratio (WHR). Information about potential confounders was collected with a self-administered questionnaire. The association between shift work and both general and abdominal obesity was established with multinomial and binary logistic regression analysis. The study sample consisted of 1683 (54.9 %) rotational shift workers and 1380 (45.1 %) day workers. Shift work was significantly associated with higher risk of overweight after adjusting for the impacts of potential confounders (OR=1.2; 95 % CI:1.04-1.4) but not with abdominal obesity. This study established that shift work was an independent risk factor for overweight in industrial shift workers. Modification of working schedules is recommended, particularly for prolonged, continuous shift work.
C1 [Rabanipour, Najmeh; Feizi, Awat] Isfahan Univ Med Sci, Student Res Ctr, Dept Biostat & Epidemiol, Esfahan, Iran.
   [Roohafza, Hamidreza; Feizi, Awat] Isfahan Univ Med Sci, Cardiac Rehabil Res Ctr, Cardiovasc Res Inst, Esfahan, Iran.
   [Tirani, Shahnaz Amani] Isfahan Univ Med Sci, Khorshid Hosp, Nutr Dept, Esfahan, Iran.
   [Sarrafzadegan, Nizal] Isfahan Univ Med Sci, Isfahan Cardiovasc Res Ctr, Cardiovasc Res Inst, Esfahan, Iran.
C3 Isfahan University of Medical Sciences; Isfahan University of Medical
   Sciences; Isfahan University of Medical Sciences; Isfahan University of
   Medical Sciences
RP Feizi, A (corresponding author), Isfahan Univ Med Sci, Cardiac Rehabil Res Ctr, Cardiovasc Res Inst, Esfahan, Iran.; Feizi, A (corresponding author), Isfahan Univ Med Sci, Dept Biostat & Epidemiol, Esfahan, Iran.
EM awat_feiz@hlth.mui.ac.ir
RI Feizi, Awat/W-3409-2017
OI Feizi, Awat/0000-0002-1930-0340; Amani Tirani,
   Shahnaz/0000-0002-8429-4864
FU Cardiovascular Research Institute of Isfahan, Iran
FX This study was funded in part by the Cardiovascular Research Institute
   of Isfahan, Iran. We are grateful to all volunteers who participated. We
   would also like to acknowledge the help of the head of Esfahan Steel
   Company and the staff of the Cardiovascular Research Institute in
   conducting the study.
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NR 39
TC 7
Z9 7
U1 0
U2 4
PU INST MEDICAL RESEARCH & OCCUPATIONAL HEALTH
PI ZAGREB
PA 2 KSAVERSKA ST P O BOX 291, ZAGREB, 00000, CROATIA
SN 0004-1254
EI 1848-6312
J9 ARH HIG RADA TOKSIKO
JI Arh. Hig. Rada. Toksikol.
PD SEP
PY 2019
VL 70
IS 3
BP 194
EP 200
DI 10.2478/aiht-2019-70-3266
PG 7
WC Public, Environmental & Occupational Health; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health; Toxicology
GA JC5BZ
UT WOS:000489295500005
PM 32597131
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Leyva-Soto, A
   Chavez-Santoscoy, RA
   Lara-Jacobo, LR
   Chavez-Santoscoy, AV
   Gonzalez-Cobian, LN
AF Leyva-Soto, Aldo
   Alejandra Chavez-Santoscoy, Rocio
   Lara-Jacobo, Linda Ramona
   Chavez-Santoscoy, Ana Vianey
   Natalia Gonzalez-Cobian, Lina
TI Daily Consumption of Chocolate Rich in Flavonoids Decreases Cellular
   Genotoxicity and Improves Biochemical Parameters of Lipid and Glucose
   Metabolism
SO MOLECULES
LA English
DT Article
DE flavonoids; dark chocolate; genotoxicity; lipid metabolism; glucose
   metabolism
ID CARDIOVASCULAR RISK-FACTORS; DNA-DAMAGE; INSULIN-RESISTANCE; DARK
   CHOCOLATE; COCOA; INFLAMMATION; FLAVANOLS; HEALTHY
AB In recent years, the incidence of atherosclerotic cardiovascular disease, obesity, and diabetes has increased largely worldwide. In the present work, we evaluated the genoprotective effect of the consumption of flavonoids-rich chocolate on 84 young volunteers. Biochemical indicators related to the prevention and treatment of cardiovascular risk and metabolic syndrome were also determined. A randomized, placebo-controlled, double-blind study was performed in the Autonomous University of Baja California. The treatments comprised the daily consumption of either 2 g of dark chocolate containing 70% cocoa, or 2 g of milk chocolate, for 6 months. The total amount of phenolic compounds and flavonoids was determined in both types of chocolate. Anthropometrical and Biochemical parameters were recorded prior to and after the study. The evaluation of the genotoxicity in buccal epithelial cells was performed throughout the duration of the study. Flavonoids from cocoa in dark chocolate significantly prevented DNA damage, and improved the nucleus integrity of cells. This effect could be related to the antioxidant capacity of the dark chocolate that decreased cellular stress. Biochemical parameters (total cholesterol, triglycerides, and LDL-cholesterol level in blood) and anthropometrical parameters (waist circumference) were improved after six months of daily intake of 2 g of dark chocolate with a 70% of cocoa.
C1 [Leyva-Soto, Aldo; Alejandra Chavez-Santoscoy, Rocio; Natalia Gonzalez-Cobian, Lina] Univ Autonoma Baja California, Fac Ciencias Quim & Ingn, Campus Tijuana,Calzada Univ 14418, Tijuana 22390, Mexico.
   [Lara-Jacobo, Linda Ramona] Inst Natl Rech Sci INRS ETE, Eau Terre Environm, Lab Ecotoxiquegenom, Rue 490 Couronne, Quebec City, PQ G1K 9A9, Canada.
   [Chavez-Santoscoy, Ana Vianey] Univ Texas Hlth Sci Ctr San Antonio, Dept Cellular & Struct Biol, 7703 Floyd Curl Dr, San Antonio, TX 78229 USA.
C3 Universidad Autonoma de Baja California; University of Quebec; Institut
   national de la recherche scientifique (INRS); University of Texas
   System; University of Texas Health Science Center at San Antonio
RP Chavez-Santoscoy, RA (corresponding author), Univ Autonoma Baja California, Fac Ciencias Quim & Ingn, Campus Tijuana,Calzada Univ 14418, Tijuana 22390, Mexico.
EM aldo.leyva@uabc.edu.mx; ale.santoscoy@gmail.com;
   linda_ramona.lara-jacobo@ete.inrs.ca; anayenaiv@gmail.com;
   ngonzalez8@uabc.edu.mx
RI ; Chavez-Santoscoy, Rocio Alejandra/AAG-5643-2020
OI Lara-Jacobo, Linda/0000-0001-9412-0916; Gonzalez Cobian, Lina
   Natalia/0000-0003-4423-3749; Chavez-Santoscoy, Rocio
   Alejandra/0000-0002-4551-1862; Leyva, Aldo/0000-0002-9811-8757
FU CONACYT [841005]; Universidad Autonoma de Baja California; Programa de
   Perfil Deseable PRODEP of SEP grant [NPTC-2016]; Marie Curie Actions
   (MSCA) [841005] Funding Source: Marie Curie Actions (MSCA)
FX This research was funded by CONACYT with scholarship of graduate
   students CVU [841005], Universidad Autonoma de Baja California and
   Programa de Perfil Deseable PRODEP of SEP grant of [NPTC-2016].
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NR 34
TC 41
Z9 42
U1 0
U2 26
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1420-3049
J9 MOLECULES
JI Molecules
PD SEP
PY 2018
VL 23
IS 9
AR 2220
DI 10.3390/molecules23092220
PG 12
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA GW9YP
UT WOS:000447365100131
PM 30200398
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Pease, LI
   Clegg, PD
   Proctor, CJ
   Shanley, DJ
   Cockell, SJ
   Peffers, MJ
AF Pease, Louise I.
   Clegg, Peter D.
   Proctor, Carole J.
   Shanley, Daryl J.
   Cockell, Simon J.
   Peffers, Mandy J.
TI Cross platform analysis of transcriptomic data identifies ageing has
   distinct and opposite effects on tendon in males and females
SO SCIENTIFIC REPORTS
LA English
DT Article
ID MESENCHYMAL STEM-CELLS; AGE-RELATED-CHANGES; PROLIFERATOR-ACTIVATED
   RECEPTORS; OXIDATIVE STRESS; DIFFERENTIAL EXPRESSION;
   GENDER-DIFFERENCES; METABOLIC SYNDROME; OXYTOCIN RECEPTOR; MOLECULAR
   CLOCKS; GENE-EXPRESSION
AB The development of tendinopathy is influenced by a variety of factors including age, gender, sex hormones and diabetes status. Cross platform comparative analysis of transcriptomic data elucidated the connections between these entities in the context of ageing. Tissue-engineered tendons differentiated from bone marrow derived mesenchymal stem cells from young (20-24 years) and old (54-70 years) donors were assayed using ribonucleic acid sequencing (RNA-seq). Extension of the experiment to microarray and RNA-seq data from tendon identified gender specific gene expression changes highlighting disparity with existing literature and published pathways. Separation of RNA-seq data by sex revealed underlying negative binomial distributions which increased statistical power. Sex specific de novo transcriptome assemblies generated fewer larger transcripts that contained miRNAs, lincRNAs and snoRNAs. The results identify that in old males decreased expression of CRABP2 leads to cell proliferation, whereas in old females it leads to cellular senescence. In conjunction with existing literature the results explain gender disparity in the development and types of degenerative diseases as well as highlighting a wide range of considerations for the analysis of transcriptomic data. Wider implications are that degenerative diseases may need to be treated differently in males and females because alternative mechanisms may be involved.
C1 [Pease, Louise I.; Clegg, Peter D.; Proctor, Carole J.; Shanley, Daryl J.; Peffers, Mandy J.] MRC Arthrit Res UK Ctr Integrated Res Musculoskel, Liverpool, Merseyside, England.
   [Clegg, Peter D.; Peffers, Mandy J.] Univ Liverpool, Inst Ageing & Chron Dis, Dept Musculoskeletal Biol, Leahurst Campus, Neston CH64 7TE, England.
   [Proctor, Carole J.] Newcastle Univ, Inst Cellular Med, Newcastle NE2 4HH, England.
   [Shanley, Daryl J.] Newcastle Univ, Inst Cell & Mol Biosci, Newcastle NE1 7RU, England.
   [Cockell, Simon J.] Newcastle Univ, Fac Med Sci, Bioinformat Support Unit, Framlington Pl, Newcastle NE2 4HH, England.
C3 University of Liverpool; Newcastle University - UK; Newcastle University
   - UK; Newcastle University - UK
RP Peffers, MJ (corresponding author), MRC Arthrit Res UK Ctr Integrated Res Musculoskel, Liverpool, Merseyside, England.; Peffers, MJ (corresponding author), Univ Liverpool, Inst Ageing & Chron Dis, Dept Musculoskeletal Biol, Leahurst Campus, Neston CH64 7TE, England.
EM M.J.Peffers@liverpool.ac.uk
RI Cockell, Simon/AFV-9495-2022; clegg, peter/A-9632-2013; Peffers,
   Mandy/AAV-9411-2020
OI Proctor, Carole/0000-0002-1366-1399; Pease, Louise/0000-0002-3792-6275;
   Cockell, Simon/0000-0002-6831-9806; Clegg, Peter/0000-0003-0632-0032;
   Shanley, Daryl/0000-0003-3096-6386; Peffers, Mandy/0000-0001-6979-0440
FU Wellcome Trust; MRC; Arthritis Research UK, MRC - Arthritis Research UK
   Centre for Integrated research into Musculoskeletal Ageing (CIMA); MRC
   [MR/P020941/1] Funding Source: UKRI
FX Mandy Peffers is funded through a Wellcome Trust Clinical Intermediate
   fellowship. This work was supported by the MRC and Arthritis Research UK
   as part of the MRC - Arthritis Research UK Centre for Integrated
   research into Musculoskeletal Ageing (CIMA).
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NR 83
TC 18
Z9 20
U1 0
U2 10
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD OCT 31
PY 2017
VL 7
AR 14443
DI 10.1038/s41598-017-14650-z
PG 20
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA FL4WA
UT WOS:000414231000044
PM 29089527
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Peng, R
   Li, Y
AF Peng, Rui
   Li, Yan
TI Association among serum cortisol, dehydroepiandrosterone-sulfate levels
   and psychiatric symptoms in men with chronic schizophrenia
SO COMPREHENSIVE PSYCHIATRY
LA English
DT Article
ID METABOLIC SYNDROME; BIPOLAR DISORDER; STRESS; NEUROTRANSMISSION;
   ANDROSTERONE; UPDATE
AB Purpose: The purpose of this study was to examine possible associations of serum levels of cortisol and dehydroepiandrosterone-sulfate (DHEA-S) with psychiatric symptoms in men with chronic schizophrenia.
   Methods: This retrospective study involved 162 men with schizophrenia and 138 age-matched healthy controls, for whom data were collected on demographic characteristics, age at disease onset, disease duration, positive and negative syndrome scale (PANSS) scores, and history of atypical antipsychotic treatment. Serum levels of cortisol and DHEA-S were calculated, as well as the ratios of the two levels. Possible correlations were explored between these levels and psychiatric symptoms before and after antipsychotic treatment.
   Results: Serum levels of cortisol and DHEA-S levels as well as the ratios of cortisol to DHEA-S levels were higher in patients than in controls (p < 0.01). Among patients, serum levels of cortisol and DHEA-S were significantly lower after treatment than before (p < 0.01), although the ratios of cortisol to DHEA-S levels remained similar. Serum levels of cortisol, DHEA-S and the ratios of the two levels were positively correlated with the negative symptoms score on the PANSS.
   Conclusions: The pathophysiology of schizophrenia may involve in the spread levels of cortisol and DHEA-S. These levels may serve as biomarkers for diagnosing schizophrenia and monitoring treatment efficacy. (C) 2017 Elsevier Inc. All rights reserved.
C1 [Peng, Rui; Li, Yan] Wuhan Univ, Remin Hosp, Dept Clin Lab, 238 Jiefang Rd, Wuhan, Peoples R China.
C3 Wuhan University
RP Li, Y (corresponding author), Wuhan Univ, Remin Hosp, Dept Clin Lab, 238 Jiefang Rd, Wuhan, Peoples R China.
EM yanlitf1120@163.com
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NR 24
TC 11
Z9 11
U1 0
U2 6
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0010-440X
EI 1532-8384
J9 COMPR PSYCHIAT
JI Compr. Psychiat.
PD JUL
PY 2017
VL 76
BP 113
EP 118
DI 10.1016/j.comppsych.2017.03.011
PG 6
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA EX6VV
UT WOS:000403381100013
PM 28482249
DA 2025-06-11
ER

PT J
AU Nakata, T
   Fujita, A
   Umeda, M
   Yoshida, H
   Inami, K
   Masuzaki, H
   Sawai, H
AF Nakata, Takaya
   Fujita, Atsuko
   Umeda, Makoto
   Yoshida, Hiroaki
   Inami, Kaoru
   Masuzaki, Hiroaki
   Sawai, Hirofumi
TI The increased ratio of 11β-hydroxysteroid dehydrogenase type 1 versus
   11β-hydroxysteroid dehydrogenase type 2 in chronic periodontitis
   irrespective of obesity
SO SPRINGERPLUS
LA English
DT Article
DE 11 beta-Hydroxysteroid dehydrogenase type 1; 11 beta-Hydroxysteroid
   dehydrogenase type 2; Chronic periodontitis; Cortisol; Obesity
ID KAPPA-B LIGAND; METABOLIC SYNDROME; GLUCOCORTICOID ACTION; IMPROVES
   HYPERGLYCEMIA; RECEPTOR ACTIVATOR; TISSUE; CORTISOL; EXPRESSION;
   INHIBITOR; STRESS
AB 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1), which converts inactive cortisone to active cortisol, has been reported to play an important role in metabolic diseases as well as chronic inflammatory diseases. The involvement of 11 beta-HSD1 in chronic periodontitis was investigated in the present study. The relationship between the levels of 11 beta-HSD1, chronic periodontitis, and body mass index (BMI) was analyzed. The expression of 11 beta-HSD1 mRNA was significantly higher in the chronic periodontitis group than in the control group. Since the expression of 11 beta-HSD2, which converts active cortisol to inactive cortisone, was slightly lower in the chronic periodontitis group than in the controls, the ratio of 11 beta-HSD1 versus 11 beta-HSD2 was significantly higher in the chronic periodontitis group than in the controls. A correlation was not observed between BMI and the level of 11 beta-HSD1 or between BMI and the ratio of 11 beta-HSD1 versus 11 beta-HSD2. These results suggested that an increase in the ratio of 11 beta-HSD1 versus 11 beta-HSD2 was associated with chronic periodontitis irrespective of obesity.
C1 [Nakata, Takaya; Fujita, Atsuko; Umeda, Makoto] Osaka Dent Univ, Dept Periodontol, 8-1 Kuzuhahanazonocho, Hirakata, Osaka 5731121, Japan.
   [Yoshida, Hiroaki] Osaka Dent Univ, Dept Oral & Maxillofacial Surg 1, 8-1 Kuzuhahanazonocho, Hirakata, Osaka 5731121, Japan.
   [Inami, Kaoru] Osaka Dent Univ, Dept Orthodont, 8-1 Kuzuhahanazonocho, Hirakata, Osaka 5731121, Japan.
   [Masuzaki, Hiroaki] Univ Ryukyus, Grad Sch Med, Rheumatol Dept Internal Med 2, Div Endocrinol Diabet & Metab,Hematol, 1 Senbaru, Nishihara, Okinawa 9030213, Japan.
   [Sawai, Hirofumi] Osaka Dent Univ, Dept Internal Med, 8-1 Kuzuhahanazonocho, Hirakata, Osaka 5731121, Japan.
C3 University of the Ryukyus
RP Sawai, H (corresponding author), Osaka Dent Univ, Dept Internal Med, 8-1 Kuzuhahanazonocho, Hirakata, Osaka 5731121, Japan.
EM sawai@cc.osaka-dent.ac.jp
FU Japan Society for the Promotion of Science [22592105, 25462941];
   Grants-in-Aid for Scientific Research [25462941, 22592105] Funding
   Source: KAKEN
FX This study was supported by Grants-in-Aid for Scientific Research (C)
   (#22592105, #25462941) from Japan Society for the Promotion of Science.
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NR 42
TC 5
Z9 5
U1 0
U2 3
PU SPRINGER INTERNATIONAL PUBLISHING AG
PI CHAM
PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND
SN 2193-1801
J9 SPRINGERPLUS
JI SpringerPlus
PD JAN 16
PY 2016
VL 5
AR 40
DI 10.1186/s40064-016-1679-6
PG 7
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA DB9ZI
UT WOS:000368875900003
PM 26835222
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Arries, EJ
   Maposa, S
AF Arries, Ebin J.
   Maposa, Sithokozile
TI Cardiovascular Risk Factors Among Prisoners
SO JOURNAL OF FORENSIC NURSING
LA English
DT Review
DE cardiovascular disease; cardiovascular risk factors; incarceration;
   integrative review hypertension; prisoners
ID CORONARY-HEART-DISEASE; POSTTRAUMATIC-STRESS-DISORDER; METABOLIC
   SYNDROME; WOMEN PRISONERS; HEALTH; PEOPLE; CARE; CUSTODY; OBESITY; DEATH
AB Background and Aim: Incarceration is characterized by inequalities in disease burden and an increased risk for cardiovascular disease (CVD). The aim of this review was to critique published empirical research studies on cardiovascular risk factors among prisoners and to summarize and synthesize current knowledge and findings across these studies.
   Design and review method: An integrative review of the studies was conducted. Cooper's five stage method was used as a framework to guide data collection, analysis, and synthesis. Quality appraisal of retrieved studies was done using a combined evaluation tool for quantitative research studies and a checklist. The following databases were searched: CINAHL, MEDLINE, PubMed, Cochrane, Indigenous Studies Portal (iPortal), Native Health Database, Criminal Justice Abstracts, and PsychInfo using keywords. Inclusion criteria were used to select published papers.
   Results and Conclusion: A total of 12 studies that met the inclusion criteria were identified and analyzed. Hypertension, among other CVD risk factors such as smoking, physical inactivity and obesity, was one of the three most common CVD risk factors found in prisoners. Women and young offenders had a higher prevalence of hypercholesterolemia. Identifying prevalent risks factors among prisoners might influence the development of CVD prevention strategies that are specifically directed to at risk prisoners.
C1 [Arries, Ebin J.; Maposa, Sithokozile] Univ Saskatchewan, Coll Nursing, Prince Albert, SK S6V 4W1, Canada.
C3 University of Saskatchewan
RP Arries, EJ (corresponding author), Univ Saskatchewan, Coll Nursing, 1301 Cent Ave, Prince Albert, SK S6V 4W1, Canada.
EM ebin.arries@usask.ca
RI Maposa, Sithokozile/V-9554-2017
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NR 76
TC 30
Z9 34
U1 0
U2 15
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1556-3693
EI 1939-3938
J9 J FORENSIC NURS
JI J. Forensic Nurs.
PD JAN-MAR
PY 2013
VL 9
IS 1
BP 52
EP 64
DI 10.1097/JFN.0b013e31827a59ef
PG 13
WC Criminology & Penology; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Criminology & Penology; Nursing
GA V37LQ
UT WOS:000209277700007
PM 24158101
OA Bronze
DA 2025-06-11
ER

PT J
AU Makino, J
   Kamiya, T
   Hara, H
   Adachi, T
AF Makino, Junya
   Kamiya, Tetsuro
   Hara, Hirokazu
   Adachi, Tetsuo
TI TPA induces the expression of EC-SOD in human monocytic THP-1 cells:
   Involvement of PKC, MEK/ERK and NOX-derived ROS
SO FREE RADICAL RESEARCH
LA English
DT Article
DE extracellular-superoxide dismutase; protein kinase C; mitogen-activated
   protein kinase; reactive oxygen species; monocytic differentiation
ID EXTRACELLULAR-SUPEROXIDE-DISMUTASE; PROTEIN-KINASE-C; NF-KAPPA-B;
   OXIDATIVE STRESS; REACTIVE OXYGEN; U937 CELLS; COS7 CELLS;
   SIGNAL-TRANSDUCTION; METABOLIC SYNDROME; COBALT CHLORIDE
AB Extracellular-superoxide dismutase (EC-SOD) is a major SOD isozyme mainly present in the vascular wall. EC-SOD is also observed in monocytes/macrophages, and its high expression contributes to the suppression of atherosclerosis by scavenging superoxide. The molecular mechanisms governing cell-specific expression of EC-SOD are mostly unknown, while the anti-oxidative effect of EC-SOD is well recognized. In this study, we investigated the expression of EC-SOD during 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced monocytic differentiation of THP-1 cells, which is not expressing its gene in the basal phase. We confirmed the significant induction of EC-SOD in a TPA time-dependent manner, and that induction was completely blocked by pre-treatment with GF109203X, an inhibitor of protein kinase C, U0126 and PD98059, inhibitors of mitogen-activated protein kinase kinase/extracellular-signal regulated kinase. Moreover, we determined the involvement of NADPH oxidase-derived reactive oxygen species in that induction. Overall, we considered that these results may contribute to clarify the cell-specific expression of EC-SOD.
C1 [Makino, Junya; Kamiya, Tetsuro; Hara, Hirokazu; Adachi, Tetsuo] Gifu Pharmaceut Univ, Lab Clin Pharmaceut, Gifu 5011196, Japan.
C3 Gifu Pharmaceutical University
RP Kamiya, T (corresponding author), Gifu Pharmaceut Univ, Lab Clin Pharmaceut, 1-25-4 Daigaku Nishi, Gifu 5011196, Japan.
EM tekamiya@gifu-pu.ac.jp
RI Kamiya, Tetsuro/AAY-7093-2021
FU Japan Society for the Promotion for Science [23790190, 21590169];
   Grants-in-Aid for Scientific Research [23790190, 21590169] Funding
   Source: KAKEN
FX The authors report no conflicts of interest. The authors alone are
   responsible for the content writing of the paper. This study was
   supported in part by a Grant-in-Aid for Scientific Research from the
   Japan Society for the Promotion for Science (TK: No. 23790190; TA: No.
   21590169).
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NR 44
TC 26
Z9 28
U1 3
U2 8
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 1071-5762
J9 FREE RADICAL RES
JI Free Radic. Res.
PD MAY
PY 2012
VL 46
IS 5
BP 637
EP 644
DI 10.3109/10715762.2012.664841
PG 8
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 915KR
UT WOS:000302024100006
PM 22313459
DA 2025-06-11
ER

PT J
AU Boersma, GJ
   Benthem, L
   van Dijk, G
   Steimer, TJ
   Scheurink, AJW
AF Boersma, Gretha J.
   Benthem, Lambertus
   van Dijk, Gertjan
   Steimer, Thierry J.
   Scheurink, Anton J. W.
TI Coping style predicts the (in)sensitivity for developing
   hyperinsulinemia on a high fat diet in rats
SO PHYSIOLOGY & BEHAVIOR
LA English
DT Article
DE Insulin; Glucose; Personality; Visceral obesity
ID ROMAN HIGH-AVOIDANCE; INSULIN-RESISTANCE; METABOLIC SYNDROME; STRESS;
   BLOOD; GLUCOCORTICOIDS; INFUSION; BEHAVIOR; GLUCOSE; MEN
AB The aim of this study was to explore interactions between coping style and diet as risk factors for developing insulin resistance in rats. We hypothesized that rats characterized by a passive coping strategy are more susceptible for developing insulin resistance and visceral obesity than proactively coping rats, particularly on a high (45%) fat diet. This hypothesis was tested by comparing 1) insulin and glucose responses to an intravenous glucose tolerance test (IVGTT), and 2) body fat distribution, in two rat models for passive and proactive coping styles. We found that the most extremely passive rats are characterized by elevated insulin levels during a IVGTT, even on chow. Moderately passive rats display normal insulin responses under chow conditions, but develop insulin resistance on a high fat diet. Proactive rats are remarkably resistant to insulin resistance and visceral obesity, even when overfeeding on a high fat diet. Carcass analysis revealed that passive rats are characterized by increased epididymal fat deposition, which is in line with the observed differences in insulin resistance. We conclude that a passive personality is prone to develop insulin resistance and visceral obesity on a palatable fat diet and a proactive personality might be protected against the development of diet-induced insulin resistance. (C) 2010 Elsevier Inc. All rights reserved.
C1 [Boersma, Gretha J.; van Dijk, Gertjan; Scheurink, Anton J. W.] Univ Groningen, Dept Neuroendocrinol, NL-9750 AA Haren, Netherlands.
   [Benthem, Lambertus] AstraZeneca R&D, Biosci Diabet Obes, Molndal, Sweden.
   [Steimer, Thierry J.] Univ Geneva, HUG, Clin Psychopharmacol Unit, CH-1211 Geneva 4, Switzerland.
C3 University of Groningen; AstraZeneca; University of Geneva
RP Boersma, GJ (corresponding author), Univ Groningen, Dept Neuroendocrinol, POB 14, NL-9750 AA Haren, Netherlands.
EM g.j.boersma@rug.nl
OI van Dijk, Gertjan/0000-0002-6565-4019
FU AstraZeneca
FX These studies were supported by an unrestricted research grant by
   AstraZeneca.
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NR 30
TC 15
Z9 15
U1 0
U2 7
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0031-9384
J9 PHYSIOL BEHAV
JI Physiol. Behav.
PD JUN 16
PY 2010
VL 100
IS 4
BP 401
EP 407
DI 10.1016/j.physbeh.2010.04.007
PG 7
WC Psychology, Biological; Behavioral Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Behavioral Sciences
GA 614LH
UT WOS:000279059800020
PM 20385160
OA Green Published
DA 2025-06-11
ER

PT J
AU Mathew, B
   Patel, SB
   Reams, GP
   Freeman, RH
   Spear, RM
   Villarreal, D
AF Mathew, Boban
   Patel, Sanjeev B.
   Reams, Garry P.
   Freeman, Ronald H.
   Spear, Robert M.
   Villarreal, Daniel
TI Obesity-hypertension: Emerging concepts in pathophysiology and treatment
SO AMERICAN JOURNAL OF THE MEDICAL SCIENCES
LA English
DT Article; Proceedings Paper
CT Annual Meeting of the Southern-Society-for-Clinical-Investigation
CY MAR 03-05, 2006
CL Atlanta, GA
DE leptin; natriuresis; endocannabinoid-1receptor; cardiac hypertrophy
ID RAT VENTRICULAR MYOCYTES; NITRIC-OXIDE; BLOOD-PRESSURE;
   CARDIAC-HYPERTROPHY; METABOLIC SYNDROME; ENDOTHELIAL-CELLS; OXIDATIVE
   STRESS; LEPTIN RECEPTOR; WEIGHT-LOSS; ACTIVATION
AB The incidence and prevalence of obesity has risen markedly in the last decade, and this epidemic represents a serious health hazard with significant morbidity and mortality. Although hypertension is recognized as one of the most serious consequences of obesity, its pathophysiology remains incompletely understood. Contemporary research suggests that the recently discovered hormone leptin may represent a common link between these 2 pathologic conditions. Leptin is primarily synthesized and secreted by adipocytes. One of the major functions of this hormone is the control of energy balance. By binding to receptors in the hypothalamus, it reduces food intake and promotes elevation in temperature and energy expenditure. In addition, increasing evidence sugtions, may play an important role in cardiovascular and renal functions. Although the relevance of endogenous leptin needs further clarification for the control of renal sodium excretion and vascular tone, it appears to be a potential pressure and volume-regulating factor in normal situations. However, in conditions of chronic hyperleptinemia, such as obesity, leptin may function pathophysiologically for the development of hypertension as well as cardiac and renal disease. Thus, in addition to weight control, reduction of circulating leptin may confer cardiovascular and renal protective effects in patients with obesity-hypertens ion.
C1 SUNY Syracuse, Upstate Med Univ, Vet Affairs Med Ctr, Dept Internal Med, Syracuse, NY USA.
   Univ Missouri, Dept Internal Med & Physiol, Columbia, MO USA.
C3 US Department of Veterans Affairs; Veterans Health Administration (VHA);
   State University of New York (SUNY) System; State University of New York
   (SUNY) Upstate Medical Center; University of Missouri System; University
   of Missouri Columbia
RP Villarreal, D (corresponding author), SUNY Syracuse, Upstate Med Univ, Dept Med, Div Cardiol, Rm 6142,750 E Adams St, Syracuse, NY 13210 USA.
EM Villarrd@upstate.edu
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NR 58
TC 31
Z9 37
U1 0
U2 2
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0002-9629
EI 1538-2990
J9 AM J MED SCI
JI Am. J. Med. Sci.
PD JUL
PY 2007
VL 334
IS 1
BP 23
EP 30
DI 10.1097/MAJ.0b013e3180959e4e
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC General & Internal Medicine
GA 191VJ
UT WOS:000248159800004
PM 17630587
DA 2025-06-11
ER

PT J
AU Bejenaru, LE
   Bita, A
   Belu, I
   Segneanu, AE
   Radu, A
   Dumitru, A
   Ciocilteu, MV
   Mogosanu, GD
   Bejenaru, C
AF Bejenaru, Ludovic Everard
   Bita, Andrei
   Belu, Ionela
   Segneanu, Adina-Elena
   Radu, Antonia
   Dumitru, Andrei
   Ciocilteu, Maria Viorica
   Mogosanu, George Dan
   Bejenaru, Cornelia
TI Resveratrol: A Review on the Biological Activity and Applications
SO APPLIED SCIENCES-BASEL
LA English
DT Review
DE resveratrol; stilbenoids; grapes; wine; biological activity;
   applications
ID CHEMOPREVENTIVE AGENT RESVERATROL; CANCER CELL-GROWTH; IN-VITRO;
   INHIBITS PROLIFERATION; NATURAL-PRODUCT; TRANS-RESVERATROL;
   BREAST-CANCER; RED WINE; OXIDATIVE STRESS; MATRIX-METALLOPROTEINASE-9
   EXPRESSION
AB Resveratrol (RSV), a naturally occurring phytoalexin, is the most important stilbenoid synthesized by plants as a defense mechanism in response to microbial aggression, toxins, or ultraviolet radiation. RSV came to the attention of researchers both as a potential chemopreventive agent and a possible explanation for the low incidence of cardiovascular disease (CVD) in French people with a high-fat diet. RSV is mainly administered as a food supplement, and its properties are evaluated in vitro or in vivo on various experimental models. RSV modulates signaling pathways that limit the spread of tumor cells, protects nerve cells from damage, is useful in the prevention of diabetes, and generally acts as an anti-aging natural compound. It was highlighted that RSV could ameliorate the consequences of an unhealthy lifestyle caused by an exaggerated caloric intake. This paper reviews the evidence supporting the beneficial effect of RSV for various pathological conditions, e.g., neoplastic diseases, neurodegeneration, metabolic syndrome, diabetes, obesity, CVDs, immune diseases, bacterial, viral, and fungal infections. The study also focused on the chromatographic analysis of trans-RSV (tRSV) in Romanian wine samples, providing a comprehensive overview of tRSV content across different types of wine.
C1 [Bejenaru, Ludovic Everard; Bita, Andrei; Mogosanu, George Dan] Univ Med & Pharm Craiova, Dept Pharmacognosy & Phytotherapy, Fac Pharm, 2 Petru Rares St, Craiova 200349, Romania.
   [Belu, Ionela] Univ Med & Pharm Craiova, Fac Pharm, Dept Pharmaceut Technol, 2 Petru Rares St, Craiova 200349, Dolj, Romania.
   [Segneanu, Adina-Elena] West Univ Timisoara ICAM WUT, Inst Adv Environm Res, 4 Oituz St, Timisoara 300086, Romania.
   [Radu, Antonia; Bejenaru, Cornelia] Univ Med & Pharm Craiova, Dept Pharmaceut Bot, Fac Pharm, 2 Petru Rares St, Craiova 200349, Romania.
   [Dumitru, Andrei] Natl Univ Sci & Technol Politehn Bucharest, Univ Ctr Pitesti, Fac Sci Phys Educ & Informat, Dept Med Assistance & Kinetotherapy, 1 Targu din Vale St, Pitesti 110040, Romania.
   [Ciocilteu, Maria Viorica] Univ Med & Pharm Craiova, Fac Pharm, Dept Analyt Chem, 2 Petru Rares St, Craiova 200349, Dolj, Romania.
C3 University of Medicine & Pharmacy of Craiova; University of Medicine &
   Pharmacy of Craiova; University of Medicine & Pharmacy of Craiova;
   National University of Science & Technology POLITEHNICA Bucharest;
   University of Medicine & Pharmacy of Craiova
RP Belu, I (corresponding author), Univ Med & Pharm Craiova, Fac Pharm, Dept Pharmaceut Technol, 2 Petru Rares St, Craiova 200349, Dolj, Romania.
EM ludovic.bejenaru@umfcv.ro; andreibita@gmail.com; ionela.belu@umfcv.ro;
   adina.segneanu@e-uvt.ro; antonia.radu@umfcv.ro; andrei.dumitru@upit.ro;
   maria.ciocilteu@umfcv.ro; george.mogosanu@umfcv.ro;
   cornelia.bejenaru@umfcv.ro
RI Radu (Blendea), Antonia/IQT-1348-2023; Ciocîlteu, Maria
   Viorica/IQS-2985-2023; Segneanu, Adina-Elena/N-3078-2019; ionela,
   belu/ABD-1976-2020; Mogosanu, George Dan/B-8776-2009; Bita,
   Andrei/R-1667-2016
OI Mogosanu, George Dan/0000-0001-6338-9277; Radu,
   Antonia/0000-0002-3448-2736; Segneanu, Adina-Elena/0000-0002-1623-8094;
   Bejenaru, Cornelia/0009-0009-3923-0018; Bita,
   Andrei/0000-0003-4715-1423; Bejenaru, Ludovic
   Everard/0009-0004-1778-7011
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NR 265
TC 10
Z9 10
U1 16
U2 35
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2076-3417
J9 APPL SCI-BASEL
JI Appl. Sci.-Basel
PD JUN
PY 2024
VL 14
IS 11
AR 4534
DI 10.3390/app14114534
PG 43
WC Chemistry, Multidisciplinary; Engineering, Multidisciplinary; Materials
   Science, Multidisciplinary; Physics, Applied
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Engineering; Materials Science; Physics
GA UA1Y5
UT WOS:001245263100001
OA gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Ballester, P
   Cerdá, B
   Arcusa, R
   Marhuenda, J
   Yamedjeu, K
   Zafrilla, P
AF Ballester, Pura
   Cerda, Begona
   Arcusa, Raul
   Marhuenda, Javier
   Yamedjeu, Karen
   Zafrilla, Pilar
TI Effect of Ginger on Inflammatory Diseases
SO MOLECULES
LA English
DT Review
DE inflammatory diseases; ginger; bioactive compounds
ID ZINGIBER-OFFICINALE-ROSCOE; NF-KAPPA-B; ULCERATIVE-COLITIS;
   RHEUMATOID-ARTHRITIS; METABOLIC SYNDROME; OXIDATIVE STRESS;
   BOWEL-DISEASE; 6-GINGEROL; LIVER; EXTRACT
AB Ulcerative colitis, Crohn's disease, rheumatoid arthritis, psoriasis, and lupus erythematosus are some of common inflammatory diseases. These affections are highly disabling and share signals such as inflammatory sequences and immune dysregulation. The use of foods with anti-inflammatory properties such as ginger (Zingiber officinale Roscoe) could improve the quality of life of these patients. Ginger is a plant widely used and known by its bioactive compounds. There is enough evidence to prove that ginger possesses multiple biological activities, especially antioxidant and anti-inflammatory capacities. In this review, we summarize the current knowledge about the bioactive compounds of ginger and their role in the inflammatory process and its signaling pathways. We can conclude that the compounds 6-shoagol, zingerone, and 8-shoagol display promising results in human and animal models, reducing some of the main symptoms of some inflammatory diseases such as arthritis. For lupus, 6-gingerol demonstrated a protective attenuating neutrophil extracellular trap release in response to phosphodiesterase inhibition. Ginger decreases NF-k beta in psoriasis, and its short-term administration may be an alternative coadjuvant treatment. Ginger may exert a function of supplementation and protection against cancer. Furthermore, when receiving chemotherapy, ginger may reduce some symptoms of treatment (e.g., nausea).
C1 [Ballester, Pura; Cerda, Begona; Arcusa, Raul; Marhuenda, Javier; Yamedjeu, Karen; Zafrilla, Pilar] Catholic Univ San Antonio Murcia, Fac Hlth Sci, Nutr Oxidat Stress & Bioavailabil Grp, Pharm, Murcia 30107, Spain.
C3 Universidad Catolica de Murcia
RP Cerdá, B (corresponding author), Catholic Univ San Antonio Murcia, Fac Hlth Sci, Nutr Oxidat Stress & Bioavailabil Grp, Pharm, Murcia 30107, Spain.
EM bcerda@ucam.edu
RI Ballester, Pura/AAD-2635-2022; Arcusa, Raúl/GQP-7591-2022; Cerdá,
   Begoña/AAC-1788-2022; Zafrilla, Pilar/JAN-5983-2023; Begona,
   Cerda/K-5993-2014
OI ZAFRILLA, PILAR/0000-0002-1463-7120; Ballester,
   Pura/0000-0002-7345-448X; Arcusa, Raul/0000-0002-4221-3528; Begona,
   Cerda/0000-0003-0385-1145
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NR 90
TC 90
Z9 95
U1 19
U2 71
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1420-3049
J9 MOLECULES
JI Molecules
PD NOV
PY 2022
VL 27
IS 21
AR 7223
DI 10.3390/molecules27217223
PG 13
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 6C6BX
UT WOS:000882098300001
PM 36364048
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Sohouli, MH
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   Melekoglu, E
   Zendehdel, M
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AF Sohouli, Mohammad Hassan
   Baniasadi, Mansoureh
   Hernandez-Ruiz, Angela
   Melekoglu, Ebru
   Zendehdel, Mona
   Soto-Mendez, Maria Jose
   Akbari, Atieh
   Zarrati, Mitra
TI Adherence to Oxidative Balance Scores is Associated with a Reduced Risk
   of Breast Cancer; A Case-Control Study
SO NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
LA English
DT Article
ID TOTAL ANTIOXIDANT CAPACITY; COLORECTAL ADENOMA; METABOLIC SYNDROME;
   PHYSICAL-ACTIVITY; DIETARY PATTERNS; PROSTATE-CANCER; STRESS; INCIDENT;
   EXPOSURES; MORTALITY
AB We aimed to examine whether anthropometric indices, dietary factors, and nutrient intakes of women with and without breast cancer (BrCa) are associated with the oxidative balance score (OBS). This case-control study was carried out among 253 patients with BrCa and 267 healthy subjects aged >18 years. The OBS was calculated by using the following 13 dietary and non-dietary anti- and prooxidant components: dietary antioxidants (selenium, fiber, beta-carotene, vitamin D, vitamin C, vitamin E, and folate), dietary prooxidants (iron and saturated and polyunsaturated fatty acids), and nondietary anti- (physical activity) and prooxidants (smoking and obesity). The binary logistic regression was used to determine the association OBS with BrCa. After adjusting for potential confounders in the final model, there was evidence that the odds of BrCa decreased with increasing categories of the OBS (OR = 0.53, 95% CI 0.28 - 0.98; P-trend = 0.021). When we made stratified analysis by menopausal status, OBS was inversely associated with odds of BrCa in premenopausal women after adjusting for potential confounders. No significant association was found between OBS and odds of BrCa among post-menopausal women. Our data suggest that OBS scores were associated with decreased BrCa risk in the overall population.
C1 [Sohouli, Mohammad Hassan] Shahid Beheshti Univ Med Sci, Fac Nutr & Food Technol, Dept Clin Nutr & Dietet, Tehran, Iran.
   [Sohouli, Mohammad Hassan; Baniasadi, Mansoureh; Akbari, Atieh] Shahid Beheshti Univ Med Sci, Canc Res Ctr, Tehran, Iran.
   [Hernandez-Ruiz, Angela; Soto-Mendez, Maria Jose] Iberoamer Nutr Fdn FINUT, Armilla, Spain.
   [Melekoglu, Ebru] Cukurova Univ, Fac Hlth Sci, Nutr & Dietet Dept, Adana, Turkey.
   [Zendehdel, Mona] Univ Tehran Med Sci, Tehran, Iran.
   [Zarrati, Mitra] Iran Univ Med Sci, Sch Publ Hlth, Dept Nutr, Tehran, Iran.
C3 Shahid Beheshti University Medical Sciences; Shahid Beheshti University
   Medical Sciences; Cukurova University; Tehran University of Medical
   Sciences; Iran University of Medical Sciences
RP Zarrati, M (corresponding author), Iran Univ Med Sci, Sch Publ Hlth, Dept Nutr, Tehran, Iran.
EM khanomaian@yahoo.com
RI Hernández Ruiz, Ángela/JND-7517-2023; Akbari, Atieh/AAX-9813-2020;
   Melekoglu, Ebru/HIR-2621-2022; Soto Mendez, Maria Jose/U-1639-2017
OI Melekoglu, Ebru/0000-0002-2342-221X; Hernandez-Ruiz,
   Angela/0000-0001-5957-0372; Soto Mendez, Maria Jose/0000-0002-1012-4715
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NR 51
TC 8
Z9 8
U1 2
U2 11
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 0163-5581
EI 1532-7914
J9 NUTR CANCER
JI Nutr. Cancer
PY 2023
VL 75
IS 1
BP 164
EP 173
DI 10.1080/01635581.2022.2102658
EA JUL 2022
PG 10
WC Oncology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Nutrition & Dietetics
GA 7B5BH
UT WOS:000830421500001
PM 35875876
DA 2025-06-11
ER

PT J
AU Askarizadeh, F
   Heirani, M
   Khorrami-Nejad, M
   Narooie-Noori, F
   Khabazkhoob, M
   Ostadrahimi, A
AF Askarizadeh, Farshad
   Heirani, Mohsen
   Khorrami-Nejad, Masoud
   Narooie-Noori, Foroozan
   Khabazkhoob, Mehdi
   Ostadrahimi, Alireza
TI Is there any connection between choroidal thickness and obesity?
SO THERAPEUTIC ADVANCES IN OPHTHALMOLOGY
LA English
DT Review
DE body mass index; choroidal thickness; enhanced depth imaging; obesity;
   optical coherence tomography
ID BODY-MASS INDEX; OPTICAL COHERENCE TOMOGRAPHY; RETINAL VESSEL DIAMETERS;
   NERVE-FIBER LAYER; WAIST-TO-HIP; DIABETIC-RETINOPATHY; OXIDATIVE STRESS;
   SUBSEQUENT PREVALENCE; METABOLIC SYNDROME; MORBID-OBESITY
AB Obesity is a health-threatening and epidemic medical condition that can affect individuals of different ages and is potentially associated with an increased risk of systemic and ocular disorders. Despite the well-documented adverse effects of obesity on different parts of the body vasculature, less published data are available concerning obesity-related consequences on the ocular vasculature. As the human choroid is a highly vascularized tissue, its morphology and function might be altered in obese individuals. The micro-structural changes within the choroid could also trigger development of subsequent functional abnormalities of the eye. Previous population-based studies have asserted an association between obesity and choroidal thickness; however, they reported conflicting patterns of association between obesity and changes in choroidal thickness. Therefore, to enhance our understanding of the changes in choroidal morphology secondary to obesity, we reviewed studies describing the micro-structural consequences of obesity on the choroidal thickness profile and its underlying physiological and anatomical basis. This review includes all original publications related to the association between choroidal thickness and obesity published until mid-2021 that were indexed in PubMed, Google Scholar, ScienceDirect, or Scopus.
C1 [Heirani, Mohsen; Khorrami-Nejad, Masoud] Univ Tehran Med Sci, Farabi Eye Hosp, Translat Ophthalmol Res Ctr, Qazvin Sq, Tehran 1336616351, Iran.
   [Askarizadeh, Farshad; Narooie-Noori, Foroozan] Tabriz Univ Med Sci, Fac Rehabil Sci, Dept Optometry, Tabriz, Iran.
   [Khabazkhoob, Mehdi] Shahid Beheshti Univ Med Sci, Sch Nursing & Midwifery, Dept Med Surg Nursing, Tehran, Iran.
   [Khabazkhoob, Mehdi] Noor Eye Hosp, Noor Res Ctr Ophthalm Epidemiol, Tehran, Iran.
   [Ostadrahimi, Alireza] Tabriz Univ Med Sci, Nutr Res Ctr, Tabriz, Iran.
C3 Tehran University of Medical Sciences; Farabi Eye Hospital; Tabriz
   University of Medical Science; Shahid Beheshti University Medical
   Sciences; Tabriz University of Medical Science
RP Heirani, M (corresponding author), Univ Tehran Med Sci, Farabi Eye Hosp, Translat Ophthalmol Res Ctr, Qazvin Sq, Tehran 1336616351, Iran.
EM Dr.heirani@hotmail.com
RI Khorrami-Nejad, Masoud/AAG-1993-2021; Khabazkhoob, Mehdi/Q-4537-2017;
   Heirani, Mohsen/J-9479-2016
OI Heirani, Mohsen/0000-0002-8426-5924; Khorrami-Nejad,
   Masoud/0000-0002-8270-9704
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NR 92
TC 4
Z9 4
U1 1
U2 5
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 2515-8414
J9 THER ADV OPHTHALMOL
JI Ther. Adv. Ophthalmol.
PD JUN
PY 2022
VL 14
AR 25158414221100649
DI 10.1177/25158414221100649
PG 10
WC Ophthalmology
WE Emerging Sources Citation Index (ESCI)
SC Ophthalmology
GA 2T8UN
UT WOS:000822743300001
PM 35795720
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Wang, ZP
   Wang, YH
   Bradbury, N
   Bravo, CG
   Schnabl, B
   Di Nardo, A
AF Wang, Zhenping
   Wang, Yanhan
   Bradbury, Nicholas
   Bravo, Carolina Gonzales
   Schnabl, Bernd
   Di Nardo, Anna
TI Skin wound closure delay in metabolic syndrome correlates with SCF
   deficiency in keratinocytes
SO SCIENTIFIC REPORTS
LA English
DT Article
ID STEM-CELL FACTOR; GROWTH-FACTOR-BETA; C-KIT; REPAIR; EXPRESSION;
   MIGRATION; IMMUNITY; MOUSE; PHASE
AB Poor wound closure due to diabetes, aging, stress, obesity, alcoholism, and chronic disease affects millions of people worldwide. Reasons wounds will not close are still unclear, and current therapies are limited. Although stem cell factor (SCF), a cytokine, is known to be important for wound repair, the cellular and molecular mechanisms of SCF in wound closure remain poorly understood. Here, we found that SCF expression in the epidermis is decreased in mouse models of delayed wound closure intended to mimic old age, obesity, and alcoholism. By using SCF conditionally knocked out mice, we demonstrated that keratinocytes' autocrine production of SCF activates a transient c-kit receptor in keratinocytes. Transient activation of the c-kit receptor induces the expression of growth factors and chemokines to promote wound re-epithelialization by increasing migration of skin cells (keratinocytes and fibroblasts) and immune cells (neutrophils) to the wound bed 24-48 h post-wounding. Our results demonstrate that keratinocyte-produced SCF is essential to wound closure due to the increased recruitment of a unique combination of skin cells and immune cells in the early phase after wounding. This discovery is imperative for developing clinical strategies that might improve the body's natural repair mechanisms for treating patients with wound-closure pathologies.
C1 [Wang, Zhenping; Bradbury, Nicholas; Bravo, Carolina Gonzales; Di Nardo, Anna] Univ Calif San Diego, Sch Med, Dept Dermatol, La Jolla, CA 92093 USA.
   [Wang, Yanhan; Schnabl, Bernd] Univ Calif San Diego, Sch Med, Div Gastroenterol, La Jolla, CA 92093 USA.
C3 University of California System; University of California San Diego;
   University of California System; University of California San Diego
RP Di Nardo, A (corresponding author), Univ Calif San Diego, Sch Med, Dept Dermatol, La Jolla, CA 92093 USA.
EM adinardo@health.ucsd.edu
RI di nardo, anna/AAI-1629-2020; Schnabl, Bernd/HCH-3471-2022
OI Gonzalez Bravo, Carolina/0000-0002-2386-4616
FU NIH-NAIAD; NIH [5R01AI106874]; NIDDK [P30 DK120515]; NIAAA [P50
   AA011999]
FX We thank Dr. Richard Gallo and his lab members for helpful discussions.
   Dr. Di Nardo is supported by the NIH-NAIAD with NIH grant 5R01AI106874.
   The study was also supported by the NIDDK-funded San Diego Digestive
   Diseases Research Center (P30 DK120515) and the NIAAA-funded Southern
   California Research Center ALPD and Cirrhosis (P50 AA011999) to Dr.
   Bernd Schnabl.
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NR 37
TC 11
Z9 11
U1 0
U2 3
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD DEC 10
PY 2020
VL 10
IS 1
AR 21732
DI 10.1038/s41598-020-78244-y
PG 12
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA PU3HK
UT WOS:000609195000088
PM 33303806
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Serrano, JCE
   Martín-Gari, M
   Cassanye, A
   Granado-Serrano, AB
   Portero-Otín, M
AF Serrano, Jose C. E.
   Martin-Gari, Meritxell
   Cassanye, Anna
   Belen Granado-Serrano, Ana
   Portero-Otin, Manuel
TI Characterization of the post-prandial insulinemic response and low
   glycaemic index of a soy beverage
SO PLOS ONE
LA English
DT Article
ID OXIDATIVE STRESS; POSTMENOPAUSAL WOMEN; METABOLIC SYNDROME; ACID;
   PROTEIN; INHIBITOR; SECRETION; GENISTEIN; ISOFLAVONES; MUSCLE
AB Soybean is recognized as rich source of bioactive compounds for the improvement of glucose homeostasis. However, the post-prandial mechanisms of action have not been extensively described. The aim of this study is to determine the changes in glucose homeostasis and related factors after acute intake of a soy beverage. Twenty-nine subjects (15 women and 14 men, with an average age of 19.5 +/- 1.2) ingested 500 mL of water, glucose (20.5 g/500 mL) and soy beverage (20 g of carbohydrate) in three separate sessions. Capillary blood glucose was monitored every 15 min until 120 min post-prandial, and blood samples were collected at baseline and after 60 min for insulin, incretin, free amino acids, antioxidant capacity and inflammation marker analysis. The increase in capillary glucose after soy-beverage intake was negligible. This is explained in part by an increase in 83% in insulin levels than induced with glucose alone, which is mainly mediated by a low insulin degradation ratio (determined by c-peptide ratio), incretins and likely also by the modulation of the antioxidant environment. No associations were observed between the insulin levels and soy amino acid uptake. It could be concluded that the acute low glycaemic response of a soy beverage may involves a relationship between incretin and insulin secretion and insulin degradation.
C1 [Serrano, Jose C. E.; Martin-Gari, Meritxell; Cassanye, Anna; Belen Granado-Serrano, Ana; Portero-Otin, Manuel] Univ Lleida, Fac Med, Dept Expt Med, Lleida, Spain.
C3 Universitat de Lleida
RP Serrano, JCE (corresponding author), Univ Lleida, Fac Med, Dept Expt Med, Lleida, Spain.
EM jceserrano@mex.udl.cat
RI Martin-Gari, Meritxell/ABF-6863-2021; Granado, Ana/F-5484-2016;
   Portero-Otin, Manuel/B-7122-2009; Serrano Casasola, Jose/C-6557-2011
OI Serrano Casasola, Jose/0000-0001-6714-6061; Martin-Gari,
   Meritxell/0000-0003-0539-7775; Casane, Anna/0000-0003-3157-7403
FU Spanish Ministry of Science and Innovation (CENIT MET-DEV-FUN); Language
   Institute of the University of Lleida; Institute Leche Pascual and
   Secretaria de Estado de Investigacion, Desarrollo e Innovacion
FX This study was supported by grants from the Spanish Ministry of Science
   and Innovation (CENIT MET-DEV-FUN) to M. Portero-Otin. This research
   article has received a grant for its linguistic revision from the
   Language Institute of the University of Lleida (2015 call). This study
   was also supported by Institute Leche Pascual and Secretaria de Estado
   de Investigacion, Desarrollo e Innovacion. The funders had no role in
   study design, data collection and analysis, decision to publish, or
   preparation of the manuscript. This study was supported by grants from
   the Spanish Ministry of Science and Innovation (CENIT MET-DEV-FUN) to M.
   Portero-Otin. This research article has received a grant for its
   linguistic revision from the Language Institute of the University of
   Lleida (2015 call).
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NR 29
TC 14
Z9 14
U1 0
U2 2
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD AUG 9
PY 2017
VL 12
IS 8
AR e0182762
DI 10.1371/journal.pone.0182762
PG 13
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA FC9YJ
UT WOS:000407196700065
PM 28793331
OA Green Submitted, gold, Green Published
DA 2025-06-11
ER

PT J
AU Giallauria, F
   Predotti, P
   Casciello, A
   Grieco, A
   Russo, A
   Viggiano, A
   Citro, R
   Ravera, A
   Ciardo, M
   Guglielmi, M
   Maggio, M
   Vigorito, C
AF Giallauria, Francesco
   Predotti, Pasquale
   Casciello, Antonio
   Grieco, Alessandra
   Russo, Angelo
   Viggiano, Anna
   Citro, Rodolfo
   Ravera, Amelia
   Ciardo, Maurizio
   Guglielmi, Michele
   Maggio, Marcello
   Vigorito, Carlo
TI Serum uric acid is associated with non-dipping circadian pattern in
   young patients (30-40 years old) with newly diagnosed essential
   hypertension
SO CLINICAL AND EXPERIMENTAL HYPERTENSION
LA English
DT Article
DE uric acid; 24-hour ambulatory blood pressure monitoring; essential
   hypertension; nondipper circadian pattern; high sensitivity C-reactive
   protein
ID AMBULATORY BLOOD-PRESSURE; OXIDATIVE STRESS; SYSTEMIC INFLAMMATION;
   ENDOTHELIAL FUNCTION; CELL-PROLIFERATION; METABOLIC SYNDROME;
   HYPERURICEMIA; MORTALITY; POPULATION; ALLOPURINOL
AB Background: We aimed at evaluating the relationship between the circadian blood pressure rhythm and UA level in young patients (30-40 years old) with newly diagnosed essential hypertension. Methods: The study included 62 essential hypertensive patients and 29 healthy controls (20 men, 35 +/- 3 years) divided into two groups according to 24-hour ABPM resuts: 30 dippers and 32 nondippers. Results: Nondippers showed significantly higher both serum UA levels compared to dippers and controls (6.1 +/- 0.7, 5.2 +/- 0.9 and 4.1 +/- 0.9 mg/dL, p < 0.001, respectively); and high sensitivity C-reactive protein (hsCRP) (4.1 +/- 2.2 mg/L, 3.3 +/- 1.9 mg/L, and 1.4 +/- 0.9 mg/L, p < 0.001, respectively). After adjusting for age, sex, body mass index, smoking, creatinine levels, hsCRP and comorbidity, multivariate logistic regression analysis revealed an independent association between serum UA levels and nondipper pattern (OR 2.44, 95%CIs 1.4-4.1, p = 0.002). Conclusion: Serum UA is independently associated with nondipper circadian pattern in young patients with newly diagnosed essential hypertension.
C1 [Giallauria, Francesco; Grieco, Alessandra; Russo, Angelo; Vigorito, Carlo] Univ Naples Federico II, Dept Translat Med Sci, Div Internal Med & Cardiac Rehabil, Via S Pansini 5, I-80131 Naples, NA, Italy.
   [Predotti, Pasquale; Viggiano, Anna; Citro, Rodolfo; Ravera, Amelia] S Giovanni Dio & Ruggi Aragona Hosp, Hyperten Care Unit, Salerno, Italy.
   [Casciello, Antonio; Guglielmi, Michele] Casa Cura Tortorella, Div Cardiol, Salerno, Italy.
   [Ciardo, Maurizio] Ignazio Veris Delli Ponti Hosp, Crit Care Unit, Scorrano, Italy.
   [Maggio, Marcello] Univ Parma, Dept Clin & Expt Med, Sect Geriatr, I-43100 Parma, Italy.
C3 University of Naples Federico II; University of Parma; University
   Hospital of Parma
RP Giallauria, F (corresponding author), Univ Naples Federico II, Dept Translat Med Sci, Div Internal Med & Cardiac Rehabil, Via S Pansini 5, I-80131 Naples, NA, Italy.
EM giallauriafrancesco@gmail.com
RI Citro, Roberta/I-1596-2012; Giallauria, Francesco/B-5681-2013; Citro,
   Rodolfo/Q-5242-2016
OI Citro, Rodolfo/0000-0002-7796-6298
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NR 48
TC 12
Z9 12
U1 0
U2 4
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1064-1963
EI 1525-6006
J9 CLIN EXP HYPERTENS
JI Clin. Exp. Hypertens.
PD FEB 17
PY 2016
VL 38
IS 2
BP 233
EP 237
DI 10.3109/10641963.2015.1081230
PG 5
WC Pharmacology & Pharmacy; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Cardiovascular System & Cardiology
GA DF3MU
UT WOS:000371249200017
PM 26817828
DA 2025-06-11
ER

PT J
AU D'Alessandro, AG
   Casamassima, D
   Jirillo, F
   Martemucci, G
AF D'Alessandro, Angela G.
   Casamassima, Donato
   Jirillo, Felicita
   Martemucci, Giovanni
TI Effects of Verbascoside Administration on the Blood Parameters and
   Oxidative Status in Jennies and Their Suckling Foals: Potential
   Improvement of Milk for Human Use
SO ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS
LA English
DT Article
DE Blood parameters; donkeys; milk; oxidative status; verbascoside
ID LOW-DENSITY-LIPOPROTEIN; LIPID-PEROXIDATION; ANTIOXIDANT STATUS;
   FREE-RADICALS; GROWTH-PERFORMANCE; METABOLIC SYNDROME; IMMUNE-RESPONSE;
   BETA-CAROTENE; IN-VITRO; STRESS
AB Background: Oxidative damage of tissues and cellular components is a primary or secondary cause of many human diseases and is associated with the welfare and productivity of farm animals. Natural antioxidants have gained attention for the prevention of oxidative damage-related diseases.
   Aim of the Study: To determine the effects of dietary supplementation with a natural polyphenol (verbascoside, VB) on the serum lipid profile, the hepatic functionality and oxidative status of jennies and their suckling foals.
   Results: Supplementation with VB over 30 days decreased in jennies the serum levels of total cholesterol, LDL cholesterol, triglycerides, bilirubin, AST and ALT, and it increased the HDL cholesterol. As markers of the oxidative status, a decrease of ROMs and TBARs, and an increase in vitamin E levels were observed. Interestingly, the suckling foals showed the same trends in the blood parameters and oxidative status.
   Conclusions: Supplementation with VB influenced the lipidic and hepatic profiles, and oxidative status of jennies and the suckling foals, and may represent a potentially novel strategy for improving the functional properties of donkey's milk for human diet and for improving the welfare of young animals.
C1 [D'Alessandro, Angela G.; Martemucci, Giovanni] Univ Bari, Dept Sci Agroambientali & Territoriali DISAAT, I-70126 Bari, Italy.
   [Casamassima, Donato] Univ Molise, Dept Agr Ambiente & Alimenti, Campobasso, Italy.
   [Jirillo, Felicita] Univ Bari, Dept Emergenza & Trapianti Organi, I-70126 Bari, Italy.
C3 Universita degli Studi di Bari Aldo Moro; University of Molise;
   Universita degli Studi di Bari Aldo Moro
RP D'Alessandro, AG (corresponding author), Univ Bari, Dept Sci Agroambientali & Territoriali DISAAT, Via G Amendola 165-A, I-70126 Bari, Italy.
EM angelagabriella.dalessandro@uniba.it
RI D'Alessandro, Angela/AAN-9075-2020
OI D'Alessandro, Angela Gabriella/0000-0002-1506-5427
FU Italian Ministry for University and Research (PRIN)
FX This research was supported by the Italian Ministry for University and
   Research (PRIN 2008). The authors wish to thank Dr. Mariella Masi for
   her support during the experimental work, and Mr. Giuseppe Masi for
   providing the experimental animals and assistance in their management.
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NR 77
TC 10
Z9 10
U1 0
U2 8
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1871-5303
EI 2212-3873
J9 ENDOCR METAB IMMUNE
JI Endocr. Metab. Immune Disord.-Drug Targets
PY 2014
VL 14
IS 2
BP 102
EP 112
DI 10.2174/1871530314666140407152347
PG 11
WC Endocrinology & Metabolism; Immunology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Immunology; Pharmacology & Pharmacy
GA CB0JW
UT WOS:000349313000004
PM 24712667
DA 2025-06-11
ER

PT J
AU Gao, CL
   Aqie, KR
   Zhu, JH
   Chen, G
   Xu, L
   Jiang, L
   Xu, Y
AF Gao, Chenlin
   Aqie, Keri
   Zhu, Jianhua
   Chen, Guo
   Xu, Ling
   Jiang, Lan
   Xu, Yong
TI MG132 Ameliorates Kidney Lesions by Inhibiting the Degradation of Smad7
   in Streptozotocin-Induced Diabetic Nephropathy
SO JOURNAL OF DIABETES RESEARCH
LA English
DT Article
ID UBIQUITIN-PROTEASOME PATHWAY; OXIDATIVE STRESS; OBSTRUCTIVE NEPHROPATHY;
   METABOLIC SYNDROME; RENAL FIBROSIS; BETA; DISEASE; EXPRESSION;
   PREVENTION
AB Background. Smad7 is the main negative regulatory protein in the transforming growth factor-beta (TGF-beta) downstream signaling pathway, which plays an important role in diabetic nephropathy (DN) and may be related to the ubiquitin proteasome pathway (UPP). Aim. We investigated the role of UPP in regulating TGF-beta/SMAD signaling and explored the therapeutic effect of the ubiquitin proteasome inhibitor MG132 on DN. Methods. Wistar rats were randomly divided into a diabetes group and a normal control group. Rats in the diabetes group were injected intraperitoneally with streptozotocin. Diabetic rats were then randomly divided into a diabetic nephropathy group (DN group), an MG132 high concentration (MH) group, and an MG132 low concentration (ML) group. After 8 weeks of treatment, 24-hour urinary microalbumin (UAlb), urinary protein/urinary creatinine (Up/Ucr) values, ALT, AST, Bcr, kidney damage, TGF-beta, Smad7, fibronectin (FN), and Smurf2 were detected. Results. The body mass and Smad7 protein expression decreased in DN group, but kidney weight, kidney weight index, UAlb, Up/Ucr, FN and Smurf2 mRNA expression, and TGF-beta protein expression increased. However, these changes diminished following treatment with MG132, and a more pronounced effect was evident in MH group compared to ML group. Conclusion. MG132 alleviates kidney damage by inhibiting Smad7 ubiquitin degradation and TGF-beta activation in DN.
C1 [Gao, Chenlin; Zhu, Jianhua; Chen, Guo; Xu, Ling; Jiang, Lan; Xu, Yong] Luzhou Med Coll, Affiliated Hosp, Dept Endocrinol, Luzhou 646000, Sichuan, Peoples R China.
   [Aqie, Keri] First Peoples Hosp Liangshan, Dept Endocrinol, Xichang 615000, Sichuan, Peoples R China.
C3 Southwest Medical University
RP Xu, Y (corresponding author), Luzhou Med Coll, Affiliated Hosp, Dept Endocrinol, Luzhou 646000, Sichuan, Peoples R China.
EM xywyll@aliyun.com
RI Xu, Yong/AGX-9165-2022; jiang, lan/T-3965-2019
FU National Natural Science Foundation of China [30670980]
FX This work was supported by Grants from the National Natural Science
   Foundation of China (30670980). The authors would like to thank the
   Clinical Center Laboratory and Cordis-Myoelectricity Laboratory for
   technical assistance. The authors also thank BioMed proofreading for
   English expression polished.
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NR 33
TC 25
Z9 26
U1 2
U2 15
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2314-6745
EI 2314-6753
J9 J DIABETES RES
JI J. Diabetes Res.
PY 2014
VL 2014
AR 918396
DI 10.1155/2014/918396
PG 8
WC Endocrinology & Metabolism; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Research & Experimental Medicine
GA 299KQ
UT WOS:000330395000001
PM 24511554
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Montesi, L
   Mazzotti, A
   Moscatiello, S
   Forlani, G
   Marchesini, G
AF Montesi, Luca
   Mazzotti, Arianna
   Moscatiello, Simona
   Forlani, Gabriele
   Marchesini, Giulio
TI Insulin resistance: mechanism and implications for carcinogenesis and
   hepatocellular carcinoma in NASH
SO HEPATOLOGY INTERNATIONAL
LA English
DT Review
DE Insulin; Drug treatment; Insulin sensitizers; Insulin secretagogs;
   Glucagon-like peptide 1
AB Introduction The effects of insulin resistance in human diseases are of paramount importance. Since the original proposal by the WHO indicating insulin resistance as the common substrate of the metabolic syndrome, large data are now available on its significance in cardiovascular diseases, nonalcoholic fatty liver disease and cancer risk. Materials and methods We reviewed the evidence linking hyperinsulinemia to insulin resistance and ultimately to increased cancer risk. Insulin resistance, by reducing substrate flux along the PI3-K pathway, is followed by compensatory hyperinsulinemia, considered a potential stimulus for cancerogenesis along the MAP-K pathway. Adaptive mechanisms of fat storage, promoted by insulin resistance, chronically maintained in an obesiogenic environment, may lead to oxidative stress and inflammation and modify the immune responses, further increasing the carcinogenic potential. The increased cancer risk associated with obesity, type 2 diabetes and nonalcoholic fatty liver may thus be fueled by hyperinsulinemia. Insulin secretagogs and insulin treatment, by raising circulating insulin levels, further increase cancer risk, whereas insulin sensitizers are associated with decreased cancer risk (all sites) and specifically decrease hepatocellular carcinoma. Likewise, drugs related to the incretin system, which are weight neutral or even reduce whole-body and hepatic fat, improve insulin sensitivity and potentially reduce the cancer risk. Conclusion New diabetes treatments might thus help decrease the future burden of diabetes-associated cancer and particularly of hepatocellular carcinoma.
C1 [Montesi, Luca; Mazzotti, Arianna; Moscatiello, Simona; Forlani, Gabriele; Marchesini, Giulio] Alma Mater Studiorum Univ, Unit Metab Dis & Clin Dietet, Bologna, Italy.
   [Marchesini, Giulio] Alma Mater Studiorum Univ, Unit Clin Dietet, Policlin S Orsola, Via Massarenti 9, I-40138 Bologna, Italy.
C3 University of Bologna; IRCCS Azienda Ospedaliero-Universitaria di
   Bologna; University of Bologna
RP Marchesini, G (corresponding author), Alma Mater Studiorum Univ, Unit Clin Dietet, Policlin S Orsola, Via Massarenti 9, I-40138 Bologna, Italy.
EM giulio.marchesini@unibo.it
RI Moscatiello, Simona/AAC-4979-2022
OI Marchesini, Giulio/0000-0003-2407-9860
FU European Community's Seventh Framework Program (FP7/2007-2013)
   [HEALTH-F2-2009-241762]
FX The authors have received funding from the European Community's Seventh
   Framework Program (FP7/2007-2013) under grant agreement no.
   HEALTH-F2-2009-241762 for the project FLIP. S.M. is supported by a
   specific research contract within the same program.
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PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1936-0533
EI 1936-0541
J9 HEPATOL INT
JI Hepatol. Int.
PD DEC
PY 2013
VL 7
SU 2
BP S814
EP S822
DI 10.1007/s12072-013-9451-2
PG 9
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA VI2TB
UT WOS:000467149000008
PM 26202296
DA 2025-06-11
ER

PT J
AU Lopes, RAM
   Neves, KB
   Carneiro, FS
   Tostes, RC
AF Lopes, Rheure A. M.
   Neves, Karla B.
   Carneiro, Fernando S.
   Tostes, Rita C.
TI Testosterone and vascular function in aging
SO FRONTIERS IN PHYSIOLOGY
LA English
DT Review
DE testosterone; aging; vascular function; cardiovascular disease
ID ANDROGEN RECEPTOR MODULATORS; ENDOTHELIAL PROGENITOR CELLS;
   CORONARY-ARTERY-DISEASE; ERECTILE DYSFUNCTION; OXIDATIVE STRESS;
   HEALTHY-MEN; CARDIOVASCULAR-DISEASE; INDUCED HYPERTENSION; REPLACEMENT
   THERAPY; METABOLIC SYNDROME
AB Androgen receptors are widely distributed in several tissues, including vascular endothelial and smooth muscle cells. Through classic cytosolic androgen receptors or membrane receptors, testosterone induces genomic and non-genomic effects, respectively. Testosterone interferes with the vascular function by increasing the production of pro-inflammatory cytokines and arterial thickness. Experimental evidence indicates that sex steroid hormones, such as testosterone modulate the synthesis and bioavailability of NO and, consequently, endothelial function, which is key for a healthy vasculature. Of interest, aging itself is accompanied by endothelial and vascular smooth muscle dysfunction. Aging-associated decline of testosterone levels is accompanied by age-related diseases, such as metabolic and cardiovascular diseases, indicating that very low levels of androgens may contribute to cardiovascular dysfunction observed in these age-related disorders or, in other words, that testosterone may have beneficial effects in the cardiovascular system. However, testosterone seems to play a negative role in the severity of renal disease. In this mini-review, we briefly comment on the interplay between aging and testosterone levels, the vascular actions of testosterone and its implications for vascular aging. Renal effects of testosterone and the use of testosterone to prevent vascular dysfunction in elderly are also addressed.
C1 [Lopes, Rheure A. M.; Neves, Karla B.; Carneiro, Fernando S.; Tostes, Rita C.] Med Sch Ribeirao Preto, Dept Pharmacol, Sao Paulo, Brazil.
RP Lopes, RAM (corresponding author), Univ Sao Paulo, Med Sch Ribeirao Preto, Dept Pharmacol, Av Bandeirantes 3900, BR-14049900 Sao Paulo, Brazil.
EM rheurealves@usp.br; rtostes@usp.br
RI Tostes, Rita/C-1025-2012; Neves, Karla Bianca/V-1606-2018; Alves-Lopes,
   Rheure/U-7347-2018; Carneiro, Fernando/G-1286-2012
OI Tostes, Rita/0000-0002-9446-0707; Neves, Karla
   Bianca/0000-0001-5158-9263; Alves-Lopes, Rheure/0000-0002-4885-6647;
   Carneiro, Fernando/0000-0003-4519-6513
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NR 105
TC 52
Z9 59
U1 0
U2 9
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA PO BOX 110, EPFL INNOVATION PARK, BUILDING I, LAUSANNE, 1015,
   SWITZERLAND
SN 1664-042X
J9 FRONT PHYSIOL
JI Front. Physiol.
PY 2012
VL 3
AR 89
DI 10.3389/fphys.2012.00089
PG 9
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA V35UH
UT WOS:000209173000087
PM 22514541
OA Green Published, Green Accepted, gold
DA 2025-06-11
ER

PT J
AU Siddiqui, S
   Fang, M
   Ni, B
   Lu, DY
   Martin, B
   Maudsley, S
AF Siddiqui, Sana
   Fang, Meng
   Ni, Bin
   Lu, Daoyuan
   Martin, Bronwen
   Maudsley, Stuart
TI Central Role of the EGF Receptor in Neurometabolic Aging
SO INTERNATIONAL JOURNAL OF ENDOCRINOLOGY
LA English
DT Review
ID EPIDERMAL-GROWTH-FACTOR; PANCREATIC-ISLET CELLS; DIETARY ENERGY-INTAKE;
   FACTOR MESSENGER-RNA; ALPHA TGF-ALPHA; MICE LACKING; INSULIN-RESISTANCE;
   OXIDATIVE STRESS; BETA-CELL; TYROSINE PHOSPHORYLATION
AB A strong connection between neuronal and metabolic health has been revealed in recent years. It appears that both normal and pathophysiological aging, as well as neurodegenerative disorders, are all profoundly influenced by this "neurometabolic" interface, that is, communication between the brain and metabolic organs. An important aspect of this "neurometabolic" axis that needs to be investigated involves an elucidation of molecular factors that knit these two functional signaling domains, neuronal and metabolic, together. This paper attempts to identify and discuss a potential keystone signaling factor in this "neurometabolic" axis, that is, the epidermal growth factor receptor (EGFR). The EGFR has been previously demonstrated to act as a signaling nexus for many ligand signaling modalities and cellular stressors, for example, radiation and oxidative radicals, linked to aging and degeneration. The EGFR is expressed in a wide variety of cells/tissues that pertain to the coordinated regulation of neurometabolic activity. EGFR signaling has been highlighted directly or indirectly in a spectrum of neurometabolic conditions, for example, metabolic syndrome, diabetes, Alzheimer's disease, cancer, and cardiorespiratory function. Understanding the positioning of the EGFR within the neurometabolic domain will enhance our appreciation of the ability of this receptor system to underpin highly complex physiological paradigms such as aging and neurodegeneration.
C1 [Siddiqui, Sana; Fang, Meng; Ni, Bin; Lu, Daoyuan; Maudsley, Stuart] NIA, Receptor Pharmacol Unit, Baltimore, MD 21224 USA.
   [Martin, Bronwen] NIA, Metab Unit, Baltimore, MD 21224 USA.
C3 National Institutes of Health (NIH) - USA; NIH National Institute on
   Aging (NIA); National Institutes of Health (NIH) - USA; NIH National
   Institute on Aging (NIA)
RP Maudsley, S (corresponding author), NIA, Receptor Pharmacol Unit, Baltimore, MD 21224 USA.
EM maudsleyst@mail.nih.gov
RI ni, bin/MHQ-4131-2025; Maudsley, Stuart/Q-4782-2019; Siddiqui,
   Sana/AAK-2583-2021; Maudsley, Stuart/O-7565-2015
OI Martin, Bronwen/0000-0002-9185-6925; Maudsley,
   Stuart/0000-0002-1868-184X
FU Intramural Research Program of the National Institute on Aging, National
   Institutes of Health
FX This work was supported by the Intramural Research Program of the
   National Institute on Aging, National Institutes of Health.
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NR 183
TC 51
Z9 52
U1 1
U2 8
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1687-8337
EI 1687-8345
J9 INT J ENDOCRINOL
JI Int. J. Endocrinol.
PY 2012
VL 2012
AR 739428
DI 10.1155/2012/739428
PG 14
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 963NF
UT WOS:000305627000001
PM 22754566
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Schug, TT
   Xu, Q
   Gao, HM
   Peres-da-Silva, A
   Draper, DW
   Fessler, MB
   Purushotham, A
   Li, XL
AF Schug, Thaddeus T.
   Xu, Qing
   Gao, Huiming
   Peres-da-Silva, Ashwin
   Draper, David W.
   Fessler, Michael B.
   Purushotham, Aparna
   Li, Xiaoling
TI Myeloid Deletion of SIRT1 Induces Inflammatory Signaling in Response to
   Environmental Stress
SO MOLECULAR AND CELLULAR BIOLOGY
LA English
DT Article
ID NF-KAPPA-B; INDUCED INSULIN-RESISTANCE; CALORIE RESTRICTION; DEPENDENT
   TRANSCRIPTION; ALTERNATIVE ACTIVATION; PULMONARY INFLAMMATION;
   GENE-EXPRESSION; CELL-SURVIVAL; PROTEIN SIR2; LIFE-SPAN
AB Macrophage activation and infiltration into resident tissues is known to mediate local inflammation and is a hallmark feature of metabolic syndrome. Members of the sirtuin family of proteins regulate numerous physiological processes, including those involved in nutrient regulation and the promotion of longevity. However, the important role that SIRT1, the leading sirtuin family member, plays in immune response remains unclear. In this study, we demonstrate that SIRT1 modulates the acetylation status of the RelA/p65 subunit of NF-kappa B and thus plays a pivotal role in regulating the inflammatory, immune, and apoptotic responses in mammals. Using a myeloid cell-specific SIRT1 knockout (Mac-SIRT1 KO) mouse model, we show that ablation of SIRT1 in macrophages renders NF-kappa B hyperacetylated, resulting in increased transcriptional activation of proinflammatory target genes. Consistent with increased proinflammatory gene expression, Mac-SIRT1 KO mice challenged with a high-fat diet display high levels of activated macrophages in liver and adipose tissue, predisposing the animals to development of systemic insulin resistance and metabolic derangement. In summary, we report that SIRT1, in macrophages, functions to inhibit NF-kappa B-mediated transcription, implying that myeloid cell-specific modulation of this sirtuin may be beneficial in the treatment of inflammation and its associated diseases.
C1 [Schug, Thaddeus T.; Xu, Qing; Peres-da-Silva, Ashwin; Purushotham, Aparna; Li, Xiaoling] NIEHS, Lab Signal Transduct, NIH, Res Triangle Pk, NC 27709 USA.
   [Gao, Huiming] NIEHS, Lab Toxicol & Pharmacol, NIH, Res Triangle Pk, NC 27709 USA.
   [Draper, David W.; Fessler, Michael B.] NIEHS, Lab Resp Biol, NIH, Res Triangle Pk, NC 27709 USA.
C3 National Institutes of Health (NIH) - USA; NIH National Institute of
   Environmental Health Sciences (NIEHS); National Institutes of Health
   (NIH) - USA; NIH National Institute of Environmental Health Sciences
   (NIEHS); National Institutes of Health (NIH) - USA; NIH National
   Institute of Environmental Health Sciences (NIEHS)
RP Li, XL (corresponding author), NIEHS, Lab Signal Transduct, NIH, POB 12233, Res Triangle Pk, NC 27709 USA.
EM lix3@niehs.nih.gov
RI gao, huiming/C-8454-2012; Li, Xiaoling/ABA-0060-2022; Fessler,
   Michael/C-6323-2019; Li, Xiaoling/A-2994-2015
OI Fessler, Michael/0000-0002-8262-8613; Li, Xiaoling/0000-0001-5920-7784
FU NIH, National Institute of Environmental Health Sciences [Z01 ES102205]
FX This research was supported by a grant from the Intramural Research
   Program of the NIH, National Institute of Environmental Health Sciences,
   to X. L. (Z01 ES102205).
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NR 44
TC 270
Z9 300
U1 0
U2 14
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0270-7306
J9 MOL CELL BIOL
JI Mol. Cell. Biol.
PD OCT
PY 2010
VL 30
IS 19
BP 4712
EP 4721
DI 10.1128/MCB.00657-10
PG 10
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA 648VB
UT WOS:000281721400013
PM 20647536
OA Green Published
DA 2025-06-11
ER

PT J
AU Tian, WW
   Liu, L
   Chen, P
   Yu, DM
   Li, QM
   Hua, H
   Zhao, JN
AF Tian, Wei-Wei
   Liu, Li
   Chen, Ping
   Yu, Dong-Mei
   Li, Qing-Miao
   Hua, Hua
   Zhao, Jun-Ning
TI Curcuma Longa (turmeric): from traditional applications to modern
   plant medicine research hotspots
SO CHINESE MEDICINE
LA English
DT Review
DE Curcuma longa L.; Traditional
   applications; Pharmacological activities; Clinical applications;
   Products
ID TYPE-2 DIABETES-MELLITUS; SYSTEMIC OXIDATIVE STRESS; FATTY
   LIVER-DISEASE; QUALITY-OF-LIFE; DOUBLE-BLIND; LIPID PROFILE;
   CHEMICAL-CONSTITUENTS; METABOLIC SYNDROME; CURCUMINOIDS; SUPPLEMENTATION
AB Turmeric, derived from the dried rhizome of Curcuma longa L., receives widespread attention because of its applications in pharmaceutical, food, cosmetic and other industries. Traditionally, it has been widely used in Ayurveda medicine and traditional Asian medicine such as traditional Chinese medicine, for treatment of digestive, respiratory and circulatory diseases, as well as skin diseases. However, a comprehensive review of traditional applications, modern clinical applications, and related products remains largely unexplored. Here, we conduct a systematic summary of its pharmacological activities, including anti-inflammatory activity, anti-oxidant activity, anti-diabetic activity, anti-tumor activity, neuroprotective activity, hepatoprotective activity, anti-microbial activity and others. Additionally, we explore the randomized controlled trials, guiding future preventive healthcare strategies and clinical practices. Furthermore, we also discuss the turmeric-related products, involving medicines, health foods, herbal dietary supplements, and cosmetics, offering novel insights into relevant product development. Totally, this review provides a comprehensive understanding of turmeric on botany, history and traditional applications, pharmacological activities, clinical applications, and related products. Finally, based on the generalized science of Chinese material madica and advanced front technologies, the future research opportunities of turmeric are briefly explored.
C1 [Tian, Wei-Wei; Liu, Li; Yu, Dong-Mei; Hua, Hua; Zhao, Jun-Ning] State Adm Tradit Chinese Med, Sichuan Inst Translat Chinese Med, Sichuan Engn Technol Res Ctr Genuine Reg Drug, Sichuan Prov Engn Res Ctr Format Principle & Qual, Chengdu 610041, Peoples R China.
   [Tian, Wei-Wei; Chen, Ping; Li, Qing-Miao] Sichuan Acad Chinese Med Sci, Chengdu 610041, Peoples R China.
   [Zhao, Jun-Ning] Natl Ctr Nanosci & Technol, Beijing 100190, Peoples R China.
C3 Chinese Academy of Sciences; National Center for Nanoscience &
   Technology, CAS
RP Hua, H; Zhao, JN (corresponding author), State Adm Tradit Chinese Med, Sichuan Inst Translat Chinese Med, Sichuan Engn Technol Res Ctr Genuine Reg Drug, Sichuan Prov Engn Res Ctr Format Principle & Qual, Chengdu 610041, Peoples R China.; Zhao, JN (corresponding author), Natl Ctr Nanosci & Technol, Beijing 100190, Peoples R China.
EM hrhr2014@163.com; zarmy@189.cn
RI tian, weiwei/GSN-8325-2022
FU National Natural Science Foundation of China [82274213]; Fundamental
   Research Funds for Sichuan Provincial Scientific Research Institutes
   [2024JDKY0026]; Sichuan Province Traditional Chinese Medicine Technology
   Industry Innovation Team Special Project [2022C009]; Special Project for
   Scientific and Technological Research of Sichuan Provincial
   Administration of Traditional Chinese Medicine [2024MS156]
FX This study was supported by the National Natural Science Foundation of
   China (No. 82274213), Fundamental Research Funds for Sichuan Provincial
   Scientific Research Institutes (No.2024JDKY0026), Sichuan Province
   Traditional Chinese Medicine Technology Industry Innovation Team Special
   Project (No. 2022C009), Special Project for Scientific and Technological
   Research of Sichuan Provincial Administration of Traditional Chinese
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NR 144
TC 0
Z9 0
U1 1
U2 1
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1749-8546
J9 CHIN MED-UK
JI Chin. Med.
PD MAY 28
PY 2025
VL 20
IS 1
AR 76
DI 10.1186/s13020-025-01115-z
PG 23
WC Integrative & Complementary Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine; Pharmacology & Pharmacy
GA 3DS3F
UT WOS:001497887100001
PM 40437595
DA 2025-06-11
ER

PT J
AU Liu, F
   Cai, HP
AF Liu, Feng
   Cai, Haipeng
TI Diabetes and calcific aortic valve disease: implications of
   glucose-lowering medication as potential therapy
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Review
DE calcific aortic valve disease; diabetes; glucose-lowering medication;
   dipeptidyl peptidase-4 inhibitors; peroxisome proliferator-activated
   receptor gamma agonists
ID VALVULAR INTERSTITIAL-CELLS; INTIMA-MEDIA THICKNESS; CARDIOVASCULAR
   OUTCOMES; METABOLIC SYNDROME; VASCULAR CALCIFICATION; OXIDIZED
   PHOSPHOLIPIDS; BLOOD-PRESSURE; AGING CHANGES; EARLY LESION; RISK-FACTORS
AB Calcific aortic valve disease (CAVD) is a progressive disease, of which the 2-year mortality is >50% for symptomatic disease. However, there are currently no pharmacotherapies to prevent the progression of CAVD unless transcatheter or surgical aortic valve replacement is performed. The prevalence of diabetes among CAVD has increased rapidly in recent decades, especially among those undergoing aortic valve replacement. Diabetes and its comorbidities, such as hypertension, hyperlipidemia, chronic kidney disease and ageing, participated jointly in the initiation and progression of CAVD, which increased the management complexity in patients with CAVD. Except from hyperglycemia, the molecular links between diabetes and CAVD included inflammation, oxidative stress and endothelial dysfunction. Traditional cardiovascular drugs like lipid-lowering agents and renin-angiotensin system blocking drugs have proven to be unsuccessful in retarding the progression of CAVD in clinical trials. In recent years, almost all kinds of glucose-lowering medications have been specifically assessed for decelerating the development of CAVD. Based on the efficacy for atherosclerotic cardiovascular disease and CAVD, this review summarized current knowledge about glucose-lowering medications as promising treatment options with the potential to retard CAVD.
C1 [Liu, Feng; Cai, Haipeng] Taizhou Univ Hosp, Taizhou Cent Hosp, Dept Cardiol, Taizhou, Peoples R China.
C3 Taizhou University
RP Cai, HP (corresponding author), Taizhou Univ Hosp, Taizhou Cent Hosp, Dept Cardiol, Taizhou, Peoples R China.
EM 1917483306@qq.com
RI Cai, Haipeng/KYR-4204-2024
FU Taizhou Science and Technology Plan [1901ky41]
FX The author(s) declare that financial support was received for the
   research and/or publication of this article. This work was supported by
   the Taizhou Science and Technology Plan (grant number:1901ky41, H.C).
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NR 214
TC 0
Z9 0
U1 0
U2 0
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD APR 28
PY 2025
VL 16
AR 1583267
DI 10.3389/fphar.2025.1583267
PG 20
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 2LG8W
UT WOS:001485344700001
PM 40356984
OA gold
DA 2025-06-11
ER

PT J
AU Abubakar, B
   Usman, D
   Sanusi, KO
   Azmi, NH
   Imam, MU
AF Abubakar, Bilyaminu
   Usman, Dawoud
   Sanusi, Kamaldeen Olalekan
   Azmi, Nur Hanisah
   Imam, Mustapha Umar
TI Preventive Epigenetic Mechanisms of Functional Foods for Type 2 Diabetes
SO DIABETOLOGY
LA English
DT Review
DE diabetes; epigenetic inheritance; functional foods; intergenerational
ID METABOLIC SYNDROME; DNA METHYLATION; INSULIN-RESISTANCE; OXIDATIVE
   STRESS; MODIFIED EGG; MELLITUS; OBESITY; RISK; ENVIRONMENT; EXPOSURE
AB Type 2 diabetes (T2D) is a growing global health problem that requires new and effective prevention and management strategies. Recent research has highlighted the role of epigenetic changes in the development and progression of T2D, and the potential of functional foods as a complementary therapy for the disease. This review aims to provide an overview of the current state of knowledge on the preventive epigenetic mechanisms of functional foods in T2D. We provide background information on T2D and its current treatment approaches, an explanation of the concept of epigenetics, and an overview of the different functional foods with demonstrated preventive epigenetic effects in T2D. We also discuss the epigenetic mechanisms by which these functional foods prevent or manage T2D, and the studies that have investigated their preventive epigenetic effects. In addition, we revisit works on the beneficial influence of functional foods against the programming and complications of parentally-triggered offspring diabetes. We also suggest, albeit based on scarce data, that epigenetic inheritance mechanistically mediates the impacts of functional nutrition against the metabolic risk of diabetes in offspring. Finally, our review highlights the importance of considering the preventive epigenetic mechanisms of functional foods as a potential avenue for the development of new prevention and management strategies for T2D.
C1 [Abubakar, Bilyaminu] Usmanu Danfodiyo Univ, Dept Pharmacol & Toxicol, PMB 2346, Sokoto, Nigeria.
   [Abubakar, Bilyaminu; Usman, Dawoud; Sanusi, Kamaldeen Olalekan; Imam, Mustapha Umar] Usmanu Danfodiyo Univ, Ctr Adv Med Res & Training, PMB 2346, Sokoto, Nigeria.
   [Usman, Dawoud; Sanusi, Kamaldeen Olalekan] Usmanu Danfodiyo Univ, Dept Physiol, PMB 2346, Sokoto, Nigeria.
   [Azmi, Nur Hanisah] Univ Malaysia Sabah, Fac Food Sci & Nutr, Kota Kinabalu 88400, Malaysia.
   [Imam, Mustapha Umar] Usmanu Danfodiyo Univ, Dept Med Biochem, PMB 2346, Sokoto, Nigeria.
C3 Universiti Malaysia Sabah
RP Imam, MU (corresponding author), Usmanu Danfodiyo Univ, Ctr Adv Med Res & Training, PMB 2346, Sokoto, Nigeria.; Imam, MU (corresponding author), Usmanu Danfodiyo Univ, Dept Med Biochem, PMB 2346, Sokoto, Nigeria.
EM sanusikamaldeen@yahoo.com; mustyimam@gmail.com
RI Abubakar, Bilyaminu/AAC-5821-2019; Imam, Mustapha/K-3490-2012; AZMI, NUR
   HANISAH/J-6735-2019; Sanusi, Kamaldeen Olalekan/A-6438-2016
OI Imam, Mustapha Umar/0000-0001-9888-4809; usman,
   dawoud/0000-0003-3016-819X; Sanusi, Kamaldeen
   Olalekan/0000-0002-9588-7710
FU CAMRET [CAMRET/2019/MSc/003, CAMRET/2019/PhD/001]
FX DU and KOS acknowledge the postgraduate sponsorship given by CAMRET
   (CAMRET/2019/MSc/003 and CAMRET/2019/PhD/001, respectively).
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NR 114
TC 4
Z9 4
U1 0
U2 4
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2673-4540
J9 DIABETOLOGY
JI Diabetol.
PD SEP
PY 2023
VL 4
IS 3
BP 259
EP 277
DI 10.3390/diabetology4030023
PG 19
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA AI8V8
UT WOS:001117937900001
OA gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Li, Z
   Wu, N
   Wang, J
   Yue, Y
   Geng, LH
   Zhang, QB
AF Li, Zhi
   Wu, Ning
   Wang, Jing
   Yue, Yang
   Geng, Lihua
   Zhang, Quanbin
TI Low molecular weight fucoidan alleviates cerebrovascular damage by
   promoting angiogenesis in type 2 diabetes mice
SO INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
LA English
DT Article
DE Fucoidan; Diabetes; Angiogenesis
ID OXIDATIVE STRESS; INSULIN SENSITIVITY; METABOLIC SYNDROME;
   ISCHEMIC-STROKE; MOUSE MODEL; INFLAMMATION; HYPOXIA; PROTEIN;
   COMPLICATIONS; INHIBITION
AB Diabetes leading to brain glucose metabolism disorders and cerebrovascular complications. Fucoidan is a kind of sulfated polysaccharides which found in brown algae, has multiply bioactivities and considered to be a promising therapeutic agent. Despite the increasing amount of evidence suggesting the diabetes protective role of fucoi-dans, the effect of fucoidan on brain abnormalities in type 2 diabetes mellitus patients remains unclear. In this study a low molecular weight fucoidan (LMWF) was obtained from Saccharina japonica and its effect on the cerebrovascular damage in db/db mice was investigated. Results were shown after LMWF treatment, the degree of cerebrovascular damage, the number of apoptotic neuronal cells and the inflammation were all decreased in db/db mice. Moreover, LMWF could up-regulates CD34 and VEGFA expression in db/db mice brain, and the subintestinal vessel angiogenesis in zebrafish was also promoted by LMWF. Moreover, the lumen formation of HUVEC endothelial cells was rescued by LMWF which was destroyed in high glucose treated endothelial cells. Further study found, LMWF alleviates vascular injury by up-regulating the expression level of phosphorylated PI3K and phosphorylated AKT. Our study indicates that LMWF has the potential to develop a cerebrovascular protection agent for type 2 diabetes patients.
C1 [Li, Zhi; Wu, Ning; Wang, Jing; Yue, Yang; Geng, Lihua; Zhang, Quanbin] Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, CAS & Shandong Prov Key Lab Expt Marine Biol, Qingdao, Peoples R China.
   [Li, Zhi; Wang, Jing; Yue, Yang; Geng, Lihua; Zhang, Quanbin] Pilot Pilot Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China.
   [Li, Zhi] Univ Chinese Acad Sci, Beijing, Peoples R China.
   [Wu, Ning] Pilot Natl Lab Marine Sci & Technol, Lab Marine Drugs & Biol Prod, Qingdao, Peoples R China.
C3 Chinese Academy of Sciences; Institute of Oceanology, CAS; Chinese
   Academy of Sciences; University of Chinese Academy of Sciences, CAS;
   Laoshan Laboratory
RP Wu, N; Zhang, QB (corresponding author), Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, CAS & Shandong Prov Key Lab Expt Marine Biol, Qingdao, Peoples R China.; Zhang, QB (corresponding author), Pilot Pilot Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China.; Wu, N (corresponding author), Pilot Natl Lab Marine Sci & Technol, Lab Marine Drugs & Biol Prod, Qingdao, Peoples R China.
EM wuning@qdio.ac.cn; qbzhang@qdio.ac.cn
RI Li, Zhi/JDM-2252-2023; Zhang, Quanbin/IUQ-3663-2023
OI Li, Zhi/0009-0005-5503-2733
FU National Natural Science Fundation of China [42176137, 81872906]; Major
   Scientific & Engineering Projects of Innovation in Shandong Province
   [2019JZZY010818]; Shandong Provincial Natural Science Foundation, China
   [ZR2019BD025]
FX We appreciate Prof. Xungang Tan of Institute of Oceanology, Chinese
   Academy of Sciences for providing Zebrafish embryos. This work was
   supported by National Natural Science Fundation of China (Grand No.
   42176137 and No. 81872906) , and supported by the Major Scientific &
   Engineering Projects of Innovation in Shandong Province (Grant No.
   2019JZZY010818) . And also partly supported by Shandong Provincial
   Natural Science Foundation, China (Grant No. ZR2019BD025) .
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NR 84
TC 13
Z9 13
U1 4
U2 50
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0141-8130
EI 1879-0003
J9 INT J BIOL MACROMOL
JI Int. J. Biol. Macromol.
PD SEP 30
PY 2022
VL 217
BP 345
EP 355
DI 10.1016/j.ijbiomac.2022.07.053
EA JUL 2022
PG 11
WC Biochemistry & Molecular Biology; Chemistry, Applied; Polymer Science
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry; Polymer Science
GA 4N5ZN
UT WOS:000854098400004
PM 35841956
DA 2025-06-11
ER

PT J
AU Raftopoulou, C
   Paltoglou, G
   Charmandari, E
AF Raftopoulou, Christina
   Paltoglou, George
   Charmandari, Evangelia
TI Association between Telomere Length and Pediatric Obesity: A Systematic
   Review
SO NUTRIENTS
LA English
DT Article
DE obesity; overweight; leukocyte telomere length; childhood; adolescence
ID BODY-MASS INDEX; DNA-DAMAGE RESPONSE; OXIDATIVE STRESS; METABOLIC
   SYNDROME; ADIPOSE-TISSUE; CARDIOVASCULAR-DISEASE; INSULIN-RESISTANCE;
   AMERICAN-INDIANS; NORMAL-WEIGHT; STEM-CELLS
AB Objective: Telomere length (TL) is a robust marker of biological aging, and increased telomere attrition is noted in adults with obesity. The primary objective of this systematic review was to summarize current knowledge on the effects of childhood obesity in TL. The secondary objective was to assess the effect of weight management interventions in TL. Methods: The following databases were searched: PubMed, Scopus, Web of Science and Heal-link.gr from inception to September 2021. The search was performed using the following combinations of terms: "telomer*" [All Fields] AND ("length" [All Fields] OR "lengths" [All Fields]) AND "obes*" [All Fields] AND ("child*" [All Fields] OR "adolescen*" [All Fields]). Results: A total of 16 original articles were included in this systematic review. Eleven of them were cross-sectional and five were lifestyle interventions. Conclusions: There was a tendency towards a negative association between childhood obesity and TL. Life-style interventions in children have been associated with increased TL peripherally, indicating a possible association of the redistribution of younger cells in the periphery with the favorable effect of these interventions. Further prospective studies with larger sample sizes that employ other markers of cell aging would potentially elucidate this important mechanistic relation.
C1 [Raftopoulou, Christina; Charmandari, Evangelia] Acad Athens, Biomed Res Fdn, Ctr Clin Expt Surg & Translat Res, Div Endocrinol & Metab, Athens 11527, Greece.
   [Paltoglou, George; Charmandari, Evangelia] Natl & Kapodistrian Univ Athens, Aghia Sophia Childrens Hosp, Med Sch, Div Endocrinol Metab & Diabet,Dept Pediat 1, Athens 11527, Greece.
C3 Academy of Athens; National & Kapodistrian University of Athens; The
   Aghia Sophia Children's Hospital
RP Charmandari, E (corresponding author), Acad Athens, Biomed Res Fdn, Ctr Clin Expt Surg & Translat Res, Div Endocrinol & Metab, Athens 11527, Greece.; Charmandari, E (corresponding author), Natl & Kapodistrian Univ Athens, Aghia Sophia Childrens Hosp, Med Sch, Div Endocrinol Metab & Diabet,Dept Pediat 1, Athens 11527, Greece.
EM xraftopoulou@yahoo.gr; gpaltoglou@med.uoa.gr;
   evangelia.charmandari@googlemail.com
RI Charmandari, Evangelia/AAF-2038-2019; Paltoglou, George/B-6944-2019
OI Charmandari, Evangelia/0000-0002-0851-6998; Raftopoulou,
   Christina/0000-0002-5132-2822
FU European Regional Development Fund of the European Union; Greek national
   funds through the Operational Program Competitiveness, Entrepreneurship
   and Innovation under the call RESEARCH-CREATE-INNOVATE [T1EDK-01386,
   MIS: 5030543]
FX This research was co-financed by the European Regional Development Fund
   of the European Union and Greek national funds through the Operational
   Program Competitiveness, Entrepreneurship and Innovation, under the call
   RESEARCH-CREATE-INNOVATE (project code: T1EDK-01386, MIS: 5030543,
   Acronym: PEDOBESITY).
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NR 156
TC 9
Z9 10
U1 1
U2 10
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD MAR
PY 2022
VL 14
IS 6
AR 1244
DI 10.3390/nu14061244
PG 18
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nutrition & Dietetics
GA 0B3LF
UT WOS:000774539800001
PM 35334902
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Nordin, A
   Bin Saim, A
   Idrus, RBH
AF Nordin, Abid
   Bin Saim, Aminuddin
   Idrus, Ruszymah Bt Hj
TI Honey Ameliorate Negative Effects in Neurodegenerative Diseases: An
   Evidence-Based Review
SO SAINS MALAYSIANA
LA English
DT Review
DE Antioxidant; honey; memory loss; neurodegenerative disease; regeneration
ID CHRONIC CEREBRAL HYPOPERFUSION; MPP+-INDUCED NEUROTOXICITY; PHENETHYL
   ESTER PROTECTS; MOUSE MODEL; ALZHEIMER-DISEASE; PINOCEMBRIN PROTECTS;
   CELLULAR SENESCENCE; MONOAMINE-OXIDASE; HEME OXYGENASE-1; INHIBITORS
AB Neurodegenerative diseases are cluster of disorders arising from neuronal cell death in the central nervous system. Its prevalence increases with increasing age. Therapeutic options for neurodegenerative disease include protection against oxidative damage, attenuation of neuroinflammation, maintenance of essential neurotransmitters, and protection against environmental factors that induce neurotoxicity. Honey with its antioxidative, anti-inflammatory, and cytoprotective effects is a potential candidate for therapy in neurodegenerative diseases. The present evidence-based review summarizes the effects of honey on neurodegenerative diseases in non-human subjects. Three electronic databases, namely PubMed, Ovid Medline and Scopus were searched for records published from inception of database to May 2020 to identify reports on the association of honey and neurodegenerative diseases. Based on the preset eligibility criteria, 8 qualified articles were selected and discussed in this review. Honey from different geological origin around the globe was used by different researcher among the studies included. Honey confers protection against oxidative stress induced by hypoxia and metabolic syndrome, aluminium toxicity, and neuroinflammation. Honey also demonstrated potential ability to inhibit neurotransmitters degrading enzymes and restore memory impairment. This review showed a sparse body of evidence on the potential of honey as neurodegenerative disease therapy.
C1 [Nordin, Abid; Idrus, Ruszymah Bt Hj] Univ Kebangsaan Malaysia, Dept Physiol, Jalan Yaacob Latif, Kuala Lumpur 56000, Federal Territo, Malaysia.
   [Nordin, Abid; Idrus, Ruszymah Bt Hj] UKM Med Ctr, Ctr Tissue Engn & Regenerat Med, Clin Block,Jalan Yaacob Latif, Kuala Lumpur 56000, Federal Territo, Malaysia.
   [Bin Saim, Aminuddin] Ampang Puteri Specialist Hosp, Ear Nose & Throat Consultant Clin, Ampang 68000, Selangor Darul, Malaysia.
C3 Universiti Kebangsaan Malaysia; Universiti Kebangsaan Malaysia
RP Idrus, RBH (corresponding author), Univ Kebangsaan Malaysia, Dept Physiol, Jalan Yaacob Latif, Kuala Lumpur 56000, Federal Territo, Malaysia.; Idrus, RBH (corresponding author), UKM Med Ctr, Ctr Tissue Engn & Regenerat Med, Clin Block,Jalan Yaacob Latif, Kuala Lumpur 56000, Federal Territo, Malaysia.
EM ruszyidrus@gmail.com
RI Nordin, Abid/AAM-2293-2021
FU Universiti Kebangsaan Malaysia
FX This research was made possible via provision of funding by Amrus Medik
   Sdn. Bhd. We would also like to acknowledge Universiti Kebangsaan
   Malaysia for the resources required in completion of the review.
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NR 70
TC 5
Z9 5
U1 0
U2 5
PU UNIV KEBANGSAAN MALAYSIA
PI SELANGOR
PA FACULTY SCIENCE & TECHNOLOGY, BANGI, SELANGOR, 43600, MALAYSIA
SN 0126-6039
J9 SAINS MALAYS
JI Sains Malays.
PD MAR
PY 2021
VL 50
IS 3
BP 791
EP 801
DI 10.17576/jsm-2021-5003-20
PG 11
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA RP0RY
UT WOS:000641445400020
OA Green Accepted, gold
DA 2025-06-11
ER

PT J
AU Wang, C
   Zhang, CC
   Li, SJ
   Yu, LL
   Tian, FW
   Zhao, JX
   Zhang, H
   Chen, W
   Zhai, QX
AF Wang, Chen
   Zhang, Chengcheng
   Li, Sijia
   Yu, Leilei
   Tian, Fengwei
   Zhao, Jianxin
   Zhang, Hao
   Chen, Wei
   Zhai, Qixiao
TI Effects of Probiotic Supplementation on Dyslipidemia in Type 2 Diabetes
   Mellitus: A Meta-Analysis of Randomized Controlled Trials
SO FOODS
LA English
DT Review
DE type 2 diabetes mellitus (TDM); dyslipidemia; meta-analysis; probiotic;
   intervention; multispecies probiotics
ID LIPID PROFILE; GLYCEMIC CONTROL; DOUBLE-BLIND; INFLAMMATORY MARKERS;
   METABOLIC SYNDROME; OXIDATIVE STRESS; CHOLESTEROL; DISEASE; RISK;
   HETEROGENEITY
AB The effectiveness of probiotic consumption in controlling dyslipidemia in type 2 diabetes mellitus (T2DM) has been unclear. We reviewed relevant randomized controlled trials (RCTs) to clarify the effect of probiotic intake on dyslipidemia in T2DM patients. The Web of Science, Scopus, PubMed and Cochrane Library databases were used for searching relevant RCTs published up to October 2020. The total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) concentrations were selected as the primary indicators for dyslipidemia. The results of 13 eligible RCTs showed that probiotic intake could significantly reduce TC (SMD: -0.23, 95% CI: (-0.37, -0.10)) and TG (SMD: -0.27, 95% CI: (-0.44, -0.11)) levels, but did not regulate LDL-C or HDL-C concentrations. Subgroup analysis showed that multispecies probiotics (>= two species), but not single-species probiotics, significantly decreased TC and TG concentrations. Furthermore, powder, but not liquid, probiotics could reduce TC and TG concentrations. This meta-analysis demonstrated that probiotic supplementation is helpful in reducing TC and TG concentrations in T2DM patients. However, more well-controlled trials are needed to clarify the benefits of probiotics on dyslipidemia in T2DM patients.
C1 [Wang, Chen; Zhang, Chengcheng; Li, Sijia; Yu, Leilei; Tian, Fengwei; Zhao, Jianxin; Zhang, Hao; Chen, Wei; Zhai, Qixiao] Jiangnan Univ, State Key Lab Food Sci & Technol, Wuxi 214122, Jiangsu, Peoples R China.
   [Wang, Chen; Zhang, Chengcheng; Li, Sijia; Yu, Leilei; Tian, Fengwei; Zhao, Jianxin; Zhang, Hao; Chen, Wei; Zhai, Qixiao] Jiangnan Univ, Sch Food Sci & Technol, Wuxi 214122, Jiangsu, Peoples R China.
   [Zhang, Hao; Chen, Wei] Jiangnan Univ, Natl Engn Res Ctr Funct Food, Wuxi 214122, Jiangsu, Peoples R China.
   [Zhang, Hao] Wuxi Translat Med Res Ctr, Wuxi 214122, Jiangsu, Peoples R China.
   [Zhang, Hao] Jiangsu Translat Med, Res Inst, Wuxi Branch, Wuxi 214122, Jiangsu, Peoples R China.
   [Zhang, Hao] Jiangnan Univ, Yangzhou Inst Food Biotechnol, Yangzhou 225004, Jiangsu, Peoples R China.
   [Chen, Wei] Beijing Technol & Business Univ BTBU, Beijing Innovat Ctr Food Nutr & Human Hlth, Beijing 100048, Peoples R China.
   [Zhai, Qixiao] Jiangnan Univ, Int Joint Res Lab Probiot, Wuxi 214122, Jiangsu, Peoples R China.
C3 Jiangnan University; Jiangnan University; Jiangnan University; Jiangnan
   University; Beijing Technology & Business University; Jiangnan
   University
RP Zhai, QX (corresponding author), Jiangnan Univ, State Key Lab Food Sci & Technol, Wuxi 214122, Jiangsu, Peoples R China.; Zhai, QX (corresponding author), Jiangnan Univ, Sch Food Sci & Technol, Wuxi 214122, Jiangsu, Peoples R China.; Zhai, QX (corresponding author), Jiangnan Univ, Int Joint Res Lab Probiot, Wuxi 214122, Jiangsu, Peoples R China.
EM 7180112085@stu.jiangnan.edu.cn; 7160112075@vip.jiangnan.edu.cn;
   6180112032@stu.jiangnan.edu.cn; leileiyu@jiangnan.edu.cn;
   fwtian@jiangnan.edu.cn; jxzhao@jiangnan.edu.cn;
   zhanghao@jiangnan.edu.cn; chenwei66@jiangnan.edu.cn;
   zhaiqixiao@jiangnan.edu.cn
RI Zhai, Qixiao/IWU-8606-2023; yu, lei/MHR-4855-2025; Wang,
   Chen/HNI-0480-2023; Chen, Wei/AAR-9817-2020
OI /0009-0006-1337-808X
FU National Natural Science Foundation of China Program [31820103010,
   31871773]; Projects of Innovation and Development Pillar Program for Key
   Industries in Southern Xinjiang of Xinjiang Production and Construction
   Corps [2018DB002]; National Key Research and Development Project
   [2018YFC1604206]; National First-Class Discipline Program of Food
   Science and Technology [JUFSTR20180102]; BBSRC Newton Fund Joint Centre
   Award; Collaborative Innovation Center of Food Safety and Quality
   Control in Jiangsu Province
FX This work was supported by the National Natural Science Foundation of
   China Program(No. 31820103010 and No. 31871773); Projects of Innovation
   and Development Pillar Program for Key Industries in Southern Xinjiang
   of Xinjiang Production and Construction Corps (2018DB002); National Key
   Research and Development Project (No. 2018YFC1604206); National
   First-Class Discipline Program of Food Science and Technology
   (JUFSTR20180102); the BBSRC Newton Fund Joint Centre Award; and
   Collaborative Innovation Center of Food Safety and Quality Control in
   Jiangsu Province.
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NR 60
TC 37
Z9 36
U1 1
U2 36
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2304-8158
J9 FOODS
JI Foods
PD NOV
PY 2020
VL 9
IS 11
AR 1540
DI 10.3390/foods9111540
PG 15
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA OW8WV
UT WOS:000593160900001
PM 33114518
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Bin-Meferij, MM
   El-Kott, AF
   Shati, AA
   Eid, RA
AF Bin-Meferij, Mashael Mohammed
   El-Kott, Attalla Farag
   Shati, Ali Abdullah
   Eid, Refaat A.
TI Ginger Extract Ameliorates Renal Damage in High Fat Diet-Induced Obesity
   in Rats: Biochemical and Ultrastructural Study
SO INTERNATIONAL JOURNAL OF MORPHOLOGY
LA English
DT Article
DE Ginger extract; Renal histology; High-fat diet (HFD); Obesity;
   Ultrastructural; Leptin; TNF-alpha
ID ZINGIBER-OFFICINALE-ROSCOE; METABOLIC SYNDROME; OXIDATIVE STRESS;
   KIDNEY-DISEASE; TNF-ALPHA; NEPHROPATHY; ACTIVATION; EXPRESSION; RHIZOME;
   IMPACT
AB Obesity is a modifiable risk factor for the development and progression of kidney disease. Obesity may harm kidneys in individuals without hypertension, diabetes, or pre-existing renal disease. Ginger, Zingiber officinale, has many beneficial pharmaceutical benefits. This study aimed to evaluate the Zingiber officinale protective effect against obesity complications which induced by high fat diet and caused renal dysfunctions. The study period was two months, and the experimental animal's groups were four, 80 Wistar rats were appropriated similarly 20 animals/group: control group; ginger extract group (GE); high-fat diet (HFD); and GE+HFD group. Body and fat weight, creatinine, leptin, TNF-alpha, total antioxidants, renal histopathological and ultrastructure were investigated. Rats in group of HFD showed a significant increase (P<0.05) in the body and fat weights, creatinine, leptin and TNF-alpha, and significant decrease (P<0.05) in total antioxidants (TAS). Ginger administration significantly showed the protective restoring the altered parameters. Furthermore, rats co-treated with ginger extract improved the histopathological and ultrastructural renal injury induced by obesity. The study concluded that the ginger extract used could suppress and decrease the renal damage induced by high-fat diet as it possesses potential medicinal values.
C1 [Bin-Meferij, Mashael Mohammed] Princess Nourah bint Abdulrahman Univ, Dept Biol, Riyadh, Saudi Arabia.
   [El-Kott, Attalla Farag; Shati, Ali Abdullah] King Khalid Univ, Coll Sci, Dept Biol, Abha, Saudi Arabia.
   [El-Kott, Attalla Farag] Damanhour Univ, Fac Sci, Dept Zool, Damanhur, Egypt.
   [Eid, Refaat A.] King Khalid Univ, Coll Med, Dept Pathol, Abha, Saudi Arabia.
C3 Princess Nourah bint Abdulrahman University; King Khalid University;
   Egyptian Knowledge Bank (EKB); Damanhour University; King Khalid
   University
RP Eid, RA (corresponding author), King Khalid Univ, Coll Med, Dept Pathol, Abha, Saudi Arabia.
EM refaat_eid@yahoo.com
RI Bin-Meferij, Mashael/HJB-1103-2022; Shati, Ali/J-8491-2012; Eid,
   Refaat/HTM-2441-2023; El-kott, Attalla/D-1971-2017
OI Eid, Refaat/0000-0001-5633-9562; Shati, Ali/0000-0003-1800-7238;
   Bin-Meferij, Mashael/0000-0002-0109-530X; El-kott,
   Attalla/0000-0001-5060-0790
FU Deanship of Scientific Research, Princess Nourah bint Abdulrahman
   University, Saudi Arabia [162/37]
FX The authors thank Deanship of Scientific Research, Princess Nourah bint
   Abdulrahman University, Saudi Arabia, for the financial support to
   complete this study (Grant No. 162/37).
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TC 4
Z9 4
U1 2
U2 8
PU SOC CHILENA ANATOMIA
PI TEMUCO
PA CASILLA 54-D, TEMUCO, 00000, CHILE
SN 0717-9502
EI 0717-9367
J9 INT J MORPHOL
JI Int. J. Morphol.
PD JUN
PY 2019
VL 37
IS 2
BP 438
EP 447
DI 10.4067/S0717-95022019000200438
PG 10
WC Anatomy & Morphology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Anatomy & Morphology
GA HW9BA
UT WOS:000466984400008
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Jamshidi, N
   Mantri, N
   Cohen, MM
AF Jamshidi, Negar
   Mantri, Nitin
   Cohen, Marc M.
TI Acute effects of dietary plant nutrients on transcriptome profiles:
   evidence from human studies
SO CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
LA English
DT Review
DE Gene expression; plant extracts; polyphenols; postprandial;
   transcriptome
ID BLOOD MONONUCLEAR-CELLS; GENE-EXPRESSION; OLIVE OIL; VEGETARIAN DIETS;
   FATTY-ACIDS; INFLAMMATORY RESPONSE; METABOLIC SYNDROME; RISK;
   PREVENTION; PROTEIN
AB The health benefits of long-term dietary plant ingestion are well-established. However, literature on acute nutritional challenges is very limited. This study aimed to identify available evidence on transcriptomics responses to acute ingestion of plants or plant extracts and identify signature gene profiles that may serve as biomarkers of health status. We systematically searched electronic databases and extracted information based-on inclusion criteria such as human clinical studies, single plant-based nutrients and outcomes reported on acute transcriptome responses. A total of 11 studies reported on acute intake of plant dietary interventions. Four studies investigating natural oil extracts with three reporting on whole plants and two studies on natural plant-derived extracts. Gene expression was found to be associated with immune response (7 studies), inflammation (9 studies), metabolism (8 studies), cellular processes and cancer. The finding of this systematic review suggests that acute ingestion may significantly impact diverse physiological and pathological pathways including inflammatory, immune, cancer and oxidative stress pathways. Transcriptomics approach is proven to be an effective strategy in discovery of these anticipated mechanisms. Further studies are now required to validate and continue exploring the short-term health impact of dietary plants and their bioactive phytochemicals on gene expression and function.
C1 [Jamshidi, Negar; Cohen, Marc M.] RMIT Univ, Sch Hlth & Biomed Sci, Bundoora, Vic 3083, Australia.
   [Mantri, Nitin] RMIT Univ, Sch Sci, Bundoora, Vic, Australia.
C3 Royal Melbourne Institute of Technology (RMIT); Royal Melbourne
   Institute of Technology (RMIT)
RP Jamshidi, N (corresponding author), RMIT Univ, Sch Hlth & Biomed Sci, Bundoora, Vic 3083, Australia.
EM evi.hlth@gmail.com
RI Jamshidi, Negar/J-6136-2019; Cohen, Marc/GWV-0933-2022
OI Cohen, Marc/0000-0002-5876-6565; Jamshidi, Negar/0000-0003-2861-2140
FU RMIT University Scholarship
FX Negar Jamshidi is a Ph.D. student supported by an RMIT University
   Scholarship. This research did not receive any specific grant from
   funding agencies in the public, commercial, or not-for-profit sectors.
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NR 79
TC 3
Z9 3
U1 0
U2 18
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1040-8398
EI 1549-7852
J9 CRIT REV FOOD SCI
JI Crit. Rev. Food Sci. Nutr.
PD JUN 16
PY 2020
VL 60
IS 11
BP 1869
EP 1880
DI 10.1080/10408398.2019.1608154
EA APR 2019
PG 12
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA LU7DN
UT WOS:000471458700001
PM 31032630
DA 2025-06-11
ER

PT J
AU Skates, E
   Overall, J
   DeZego, K
   Wilson, M
   Esposito, D
   Lila, MA
   Komarnytsky, S
AF Skates, Emily
   Overall, John
   DeZego, Katelyn
   Wilson, Mickey
   Esposito, Debora
   Lila, Mary Ann
   Komarnytsky, Slavko
TI Berries containing anthocyanins with enhanced methylation profiles are
   more effective at ameliorating high fat diet-induced metabolic damage
SO FOOD AND CHEMICAL TOXICOLOGY
LA English
DT Article
DE Bioactive food components; Polyphenols; Obesity; Diabetes;
   Bioenergetics; Functional food
ID INFLAMMATORY MARKERS; GENE-EXPRESSION; RISK-FACTORS; DOUBLE-BLIND;
   LIPIDS; EXTRACT; MICE; OVERWEIGHT; BLUEBERRY; OBESITY
AB Driven by the need for alternative whole food options to manage metabolic syndrome, multiple dietary interventions are suggested to achieve a better control of metabolic risk factors and molecular networks that regulate cellular energy metabolism. It is generally accepted that anthocyanin-rich diets are beneficial for maintaining healthy body weight, improving glucose and lipid metabolism, and determining inflammatory status of key metabolic tissues. However, anthocyanins are a structurally diverse group of phenolic compounds and their individual contributions to improving metabolic health are not clear. In this study, we show that consumption of berries containing anthocyanins with enhanced methylation profiles (malvidin and petunidin) is more effective at reducing high fat diet-induced metabolic damage in the C57BL/6 mouse model of polygenic obesity. Blueberries and Concord grapes (57% and 33% anthocyanins as malvidin, petunidin, or peonidin, respectively) improved body composition through individual significant effects on energy expenditure and increased activity. Methylated anthocyanins are also more effective at enhancing mitochondrial respiration and dissipation of the mitochondrial proton gradient (proton leak) in adipose tissue, thus counteracting mitochondrial dysfunction associated with metabolic stress. Together, these results provide direct proof of the higher protective potential of methylated anthocyanins against the metabolic consequences of chronic exposure to calorie-dense foods.
C1 [Skates, Emily; Overall, John; DeZego, Katelyn; Wilson, Mickey; Esposito, Debora; Lila, Mary Ann; Komarnytsky, Slavko] North Carolina State Univ, Plants Human Hlth Inst, North Carolina Res Campus,600 Laureate Way, Kannapolis, NC 28081 USA.
   [Skates, Emily] Univ Surrey, Sch Biosci & Med, Guildford, Surrey, England.
   [Overall, John; Lila, Mary Ann; Komarnytsky, Slavko] North Carolina State Univ, Dept Food Bioproc & Nutr Sci, 400 Dan Allen Dr, Raleigh, NC 27695 USA.
   [DeZego, Katelyn] Catawba Coll, Dept Biol, 2300 W Inns St, Salisbury, NC 28144 USA.
   [Esposito, Debora] NC State Univ, Dept Anim Sci, 120 Broughton Dr, Raleigh, NC 27695 USA.
C3 North Carolina State University; University of Surrey; North Carolina
   State University; North Carolina State University
RP Komarnytsky, S (corresponding author), North Carolina State Univ, Plants Human Hlth Inst, North Carolina Res Campus,600 Laureate Way, Kannapolis, NC 28081 USA.
EM komarnytsky@ncsu.edu
RI Overall, John/AAL-1812-2020; Komarnytsky, Slavko/A-9575-2009
OI Lila, Mary Ann/0000-0002-4928-3836; Komarnytsky,
   Slavko/0000-0003-4665-4993; Overall, John/0000-0001-7831-4155; Esposito,
   Debora/0000-0001-9689-7622
FU NCSU Research and Innovation seed grant [2012-2246]; UGPN Research
   Collaboration fund; NCSU faculty start-up funds; Cell Culture and
   Phenotyping Core of the Plants for Human Health Institute, North
   Carolina State University
FX This work was supported in part by NCSU Research and Innovation seed
   grant 2012-2246 (MAL, SIC), UGPN Research Collaboration fund 2016 (SK),
   NCSU faculty start-up funds (SK), and the Cell Culture and Phenotyping
   Core of the Plants for Human Health Institute, North Carolina State
   University. All authors have read the journal's policy on disclosure of
   potential conflicts of interest and have none to declare.
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NR 35
TC 45
Z9 48
U1 2
U2 37
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0278-6915
EI 1873-6351
J9 FOOD CHEM TOXICOL
JI Food Chem. Toxicol.
PD JAN
PY 2018
VL 111
BP 445
EP 453
DI 10.1016/j.fct.2017.11.032
PG 9
WC Food Science & Technology; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Toxicology
GA FT6EW
UT WOS:000423248100039
PM 29196236
DA 2025-06-11
ER

PT J
AU Muralidhar, MN
   Prasad, SMVK
   Battula, KK
   Giridharan, N
   Kalashikam, RR
AF Muralidhar, M. N.
   Prasad, S. M. V. K.
   Battula, Kiran Kumar
   Giridharan, N., V
   Kalashikam, Rajender Rao
TI Differential response of rat strains to obesogenic diets underlines the
   importance of genetic makeup of an individual towards obesity
SO SCIENTIFIC REPORTS
LA English
DT Article
ID HIGH-FAT DIET; INSULIN-RESISTANCE; GLUCOSE-INTOLERANCE; HIGH-SUCROSE;
   METABOLIC SYNDROME; HIGH-CARBOHYDRATE; ADIPONECTIN; LEPTIN; WNIN;
   EXPRESSION
AB Obesity, a multifactorial disorder, results from a chronic imbalance of energy intake vs. expenditure. Apart from excessive consumption of high calorie diet, genetic predisposition also seems to be equally important for the development of obesity. However, the role of genetic predisposition in the etiology of obesity has not been clearly delineated. The present study addresses this problem by selecting three rat strains (WNIN, F-344, SD) with different genetic backgrounds and exposing them to high calorie diets. Rat strains were fed HF, HS, and HFS diets and assessed for physical, metabolic, biochemical, inflammatory responses, and mRNA expression. Under these conditions: significant increase in body weight, visceral adiposity, oxidative stress and systemic pro-inflammatory status; the hallmarks of central obesity were noticed only in WNIN. Further, they developed altered glucose and lipid homeostasis by exhibiting insulin resistance, impaired glucose tolerance, dyslipidemia and fatty liver condition. The present study demonstrates that WNIN is more prone to develop obesity and associated co-morbidities under high calorie environment. It thus underlines the cumulative role of genetics (nature) and diet (nurture) towards the development of obesity, which is critical for understanding this epidemic and devising new strategies to control and manage this modern malady.
C1 [Muralidhar, M. N.; Prasad, S. M. V. K.; Battula, Kiran Kumar; Giridharan, N., V; Kalashikam, Rajender Rao] Natl Inst Nutr, Natl Ctr Lab Anim Sci, Lab Mol Genet, Hyderabad 500007, Telangana, India.
C3 Indian Council of Medical Research (ICMR); ICMR - National Animal
   Resource Facility for Biomedical Research (NARFBR); ICMR - National
   Institute of Nutrition (NIN)
RP Kalashikam, RR (corresponding author), Natl Inst Nutr, Natl Ctr Lab Anim Sci, Lab Mol Genet, Hyderabad 500007, Telangana, India.
EM rkrajender@yahoo.com
RI Kalashikam, Rajender/C-8257-2009
OI Prasad, SMVK/0000-0003-3300-9215; Battula, Kiran
   Kumar/0000-0002-1944-8660
FU National Institute of Nutrition - ICMR, Government of India; National
   Institute of Nutrition-ICMR [10-NC06]; DBT-India [BT/PR
   14710/MED/30/570/2010]
FX We thank director, National Institute of Nutrition - ICMR, Government of
   India, for their support. This work was supported by National Institute
   of Nutrition-ICMR, Intramural grants No. 10-NC06 and DBT-India grants
   No. BT/PR 14710/MED/30/570/2010.
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NR 60
TC 16
Z9 18
U1 0
U2 16
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD AUG 22
PY 2017
VL 7
AR 9162
DI 10.1038/s41598-017-09149-6
PG 12
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA FE4FN
UT WOS:000408169900002
PM 28831087
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Riordan, JD
   Nadeau, JH
AF Riordan, Jesse D.
   Nadeau, Joseph H.
TI Modeling progressive non-alcoholic fatty liver disease in the laboratory
   mouse
SO MAMMALIAN GENOME
LA English
DT Article
ID ACYL-COA OXIDASE; HUMAN HEPATOCELLULAR-CARCINOMA; ENDOPLASMIC-RETICULUM
   STRESS; GLYCINE-N-METHYLTRANSFERASE; ACTIVATED RECEPTOR-ALPHA;
   METHIONINE ADENOSYLTRANSFERASE 1A; FOLATE-DEFICIENT DIET; HEPATIC
   STEATOSIS; PEROXISOME PROLIFERATOR; METABOLIC SYNDROME
AB Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease in the world and its prevalence is rising. In the absence of disease progression, fatty liver poses minimal risk of detrimental health outcomes. However, advancement to non-alcoholic steatohepatitis (NASH) confers a markedly increased likelihood of developing severe liver pathologies, including fibrosis, cirrhosis, organ failure, and cancer. Although a substantial percentage of NAFLD patients develop NASH, the genetic and molecular mechanisms driving this progression are poorly understood, making it difficult to predict which patients will ultimately develop advanced liver disease. Deficiencies in mechanistic understanding preclude the identification of beneficial prognostic indicators and the development of effective therapies. Mouse models of progressive NAFLD serve as a complementary approach to the direct analysis of human patients. By providing an easily manipulated experimental system that can be rigorously controlled, they facilitate an improved understanding of disease development and progression. In this review, we discuss genetically- and chemically-induced models of NAFLD that progress to NASH, fibrosis, and liver cancer in the context of the major signaling pathways whose disruption has been implicated as a driving force for their development. Additionally, an overview of nutritional models of progressive NAFLD is provided.
C1 [Riordan, Jesse D.; Nadeau, Joseph H.] Pacific Northwest Res Inst, Seattle, WA 98122 USA.
RP Riordan, JD (corresponding author), Pacific Northwest Res Inst, Seattle, WA 98122 USA.
EM jriordan@pnri.org
RI Riordan, Jesse/G-3582-2017
OI Riordan, Jesse/0000-0001-6734-3954
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NR 163
TC 28
Z9 35
U1 2
U2 19
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0938-8990
EI 1432-1777
J9 MAMM GENOME
JI Mamm. Genome
PD OCT
PY 2014
VL 25
IS 9-10
SI SI
BP 473
EP 486
DI 10.1007/s00335-014-9521-3
PG 14
WC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
   Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
   Genetics & Heredity
GA AP6FT
UT WOS:000342173700011
PM 24802098
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Gawron-Skarbek, A
   Chrzczanowicz, J
   Kostka, J
   Nowak, D
   Drygas, W
   Jegier, A
   Kostka, T
AF Gawron-Skarbek, Anna
   Chrzczanowicz, Jacek
   Kostka, Joanna
   Nowak, Dariusz
   Drygas, Wojciech
   Jegier, Anna
   Kostka, Tomasz
TI Cardiovascular Risk Factors and Total Serum Antioxidant Capacity in
   Healthy Men and in Men with Coronary Heart Disease
SO BIOMED RESEARCH INTERNATIONAL
LA English
DT Article
ID MIDDLE-AGED MEN; OXIDATIVE STRESS; URIC-ACID; PHYSICAL-ACTIVITY; PLASMA;
   OBESITY; OLDER; ASSOCIATION; WOMEN; YOUNG
AB Whether the incidence of coronary heart disease (CHD) is related to a decrease in total antioxidant capacity (TAC) has not yet been completely clarified. We assessed TAC of blood serum in a group of 163 men with CHD aged 34.8-77.0 years and in 163 age-matched peers without CHD. Two spectrophotometric methods were applied to assess TAC: ferric reducing ability of serum (TAC-FRAS) and 2.2-diphenyl-1-picryl-hydrazyl (TAC-DPPH) tests. In the CHD group, multivariate analysis revealed that uric acid (UA), triglycerides, and systolic blood pressure contributed independently to the TAC-FRAS variance. TAC-DPPH was favorably predicted by UA concentration, but negatively so by current smoking and glucose levels. In men without CHD, UA was the only independent determinant of both TAC-FRAS and TAC-DPPH. Presence of CHD was not an independent predictor of TAC-observed between-group differences (higher TAC in CHD patients) disappeared after adjustment for other confounders. We conclude that UA is the main determinant of TAC of blood serum in men. TAC is not directly influenced by age or CHD but is related to several indices of overweight/obesity and laboratory measures of metabolic syndrome, especially in patients with CHD.
C1 [Gawron-Skarbek, Anna; Chrzczanowicz, Jacek; Kostka, Tomasz] Med Univ Lodz, Dept Geriatr, PL-90647 Lodz, Poland.
   [Gawron-Skarbek, Anna; Chrzczanowicz, Jacek; Drygas, Wojciech; Kostka, Tomasz] Med Univ Lodz, Dept Prevent Med, PL-90752 Lodz, Poland.
   [Gawron-Skarbek, Anna] Med Univ Lodz, Dept Hyg & Hlth Promot, PL-90251 Lodz, Poland.
   [Chrzczanowicz, Jacek] Copernicus Mem Hosp, Cardiac Rehabil Ctr, PL-93438 Lodz, Poland.
   [Kostka, Joanna] Med Univ Lodz, Dept Phys Med, PL-90647 Lodz, Poland.
   [Nowak, Dariusz] Med Univ Lodz, Dept Clin Physiol, PL-92215 Lodz, Poland.
   [Jegier, Anna] Med Univ Lodz, Dept Sports Med, PL-92213 Lodz, Poland.
C3 Medical University Lodz; Medical University Lodz; Medical University
   Lodz; Medical University Lodz; Medical University Lodz; Medical
   University Lodz
RP Kostka, T (corresponding author), Med Univ Lodz, Dept Geriatr, Pl Hallera 1, PL-90647 Lodz, Poland.
EM tomaszkostka@wp.pl
RI Kostka, Joanna/S-9965-2016; Drygas, Wojciech/GLR-9863-2022;
   Gawron-Skarbek, Anna/G-3486-2014; Stefanadis,
   Christodoulos/ABH-2232-2020
OI Jegier, Anna/0000-0003-4737-2226; Gawron-Skarbek,
   Anna/0000-0002-2953-4060; Stefanadis, Christodoulos/0000-0001-5974-6454;
   Nowak, Dariusz/0000-0003-3445-6930; Drygas,
   Wojciech/0000-0002-4351-6459; Kostka, Tomasz/0000-0003-0437-650X;
   kostka, joanna/0000-0002-6256-1669
FU Ministry of Education and Science [2 P05D 070 30]; State Committee for
   Scientific Research; Medical University of Lodz [503/6-077-01/503-01];
   Healthy Ageing Research Centre Project [REGPOT-2012-2013-1]
FX This study was supported by Grant no. 2 P05D 070 30 from the Ministry of
   Education and Science and the State Committee for Scientific Research
   and by Grant no. 503/6-077-01/503-01 from the Medical University of
   Lodz. The authors were partially supported by the Healthy Ageing
   Research Centre Project (REGPOT-2012-2013-1, 7FP).
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NR 47
TC 34
Z9 34
U1 0
U2 1
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2314-6133
EI 2314-6141
J9 BIOMED RES INT
JI Biomed Res. Int.
PY 2014
VL 2014
AR 216964
DI 10.1155/2014/216964
PG 8
WC Biotechnology & Applied Microbiology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Research & Experimental Medicine
GA AN7BW
UT WOS:000340754500001
PM 25180177
OA Green Published, hybrid, Green Submitted
DA 2025-06-11
ER

PT J
AU Hwang, IC
   Kim, KK
   Kim, JH
   Lee, KR
AF Hwang, In Cheol
   Kim, Kyoung Kon
   Kim, Jeong Heon
   Lee, Kyu Rae
TI General and central obesity were significantly correlated with blood
   lead level in non-smoking, general population aged 30-50, without
   hypertension
SO AMERICAN JOURNAL OF THE MEDICAL SCIENCES
LA English
DT Article
DE General obesity; Central obesity; Lead; Non-smoking; Without
   hypertension
ID KOREA NATIONAL-HEALTH; WAIST CIRCUMFERENCE; METABOLIC SYNDROME;
   ASSOCIATION; EXPOSURE; WOMEN
AB Introduction: To investigate the association between obesity and blood lead level (BLL) in the general population after controlled for menopause, blood pressure, calcium, and smoking; we assessed the relationship between BMI, WC (Waist Circumference), and blood lead levels in the non-smoking middle-aged subjects without hypertension among 2018 KNHANES. All data were recategorized into S1 (BMI<25 kg/m(2) & WC<90 cm), S2 (intermediate), and S3 (BMI>25 kg/m(2) & WC>90 cm). Methods: We made the log transformation of blood lead levels to bring them closer to a normal distribution. Logarithmic transformed BLL was closely related to BMI (p=.010) and WC (p=.020) after adjusting for sociodemographic, energy, working factors, and cardiometabolic variables. The prevalence of ratios of S3, S2, and S1 was comparable according to the quarterly group of BLL. Results and conclusions: Blood lead levels might increase oxidative stress on triglycerides and low high-density lipoprotein (HDL)-cholesterol; consequently, lead exposure might form peroxynitrite, a reactive oxygen substrate (ROS) susceptible to destroying lipids. Consequently, obesity was significantly correlated with logarithmic blood lead levels irrespective of sociodemographic, energy, working, and cardiometabolic factors in the non-smoking middle-aged population without hypertension. Further controlled clinical trials would be considered.
C1 [Hwang, In Cheol; Kim, Kyoung Kon] Gachon Univ, Coll Med, Gil Med Ctr, Family Med, Incheon, South Korea.
   [Kim, Jeong Heon] Gachon Univ, Coll Med, Gil Med Ctr, Incheon, South Korea.
   [Lee, Kyu Rae] Gachon Univ, Dongincheon Gil Hosp, Coll Med, Family Med, Incheon, South Korea.
C3 Gachon University; Gachon University; Gachon University
RP Lee, KR (corresponding author), Gachon Univ, Dongincheon Gil Hosp, Coll Med, Family Med, Incheon, South Korea.
EM baria0228@daum.net
OI lee, kyu rae/0000-0003-2178-0459
FU Gachon University Gil Medical Center [FRD2021-14]
FX Dr. Hwang received the funding of Gachon University Gil Medical Center
   (no. FRD2021-14)
CR [Anonymous], 2020, Obesity prevalence rate
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NR 31
TC 0
Z9 0
U1 1
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0002-9629
EI 1538-2990
J9 AM J MED SCI
JI Am. J. Med. Sci.
PD APR
PY 2025
VL 369
IS 4
BP 467
EP 471
DI 10.1016/j.amjms.2024.11.007
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 1OC3Z
UT WOS:001469626700001
PM 39586424
DA 2025-06-11
ER

PT J
AU Kim, J
   Jeong, SY
   Han, SD
   Park, S
   Kim, S
   Kim, TM
AF Kim, Jimin
   Jeong, Seon-Yeong
   Han, Sang-Deok
   Park, Somi
   Kim, Soo
   Kim, Tae Min
TI Multifaceted action of stem cell-derived extracellular vesicles for
   nonalcoholic steatohepatitis
SO JOURNAL OF CONTROLLED RELEASE
LA English
DT Article
DE Extracellular vesicle; Induced mesenchymal stem cell; Nonalcoholic
   steatohepatitis; Regeneration
ID ACTIVATED PROTEIN-KINASE; HORMONE-SENSITIVE LIPASE; FATTY LIVER;
   INSULIN-RESISTANCE; AMPK PHOSPHORYLATES; HEPATIC STEATOSIS; EXOSOMES;
   LIPOLYSIS; ANGIOGENESIS; PATHOGENESIS
AB Nonalcoholic steatohepatitis (NASH) is a chronic liver disease associated with metabolic syndrome. Extracellular vesicles (EVs) are essential signaling mediators containing functional biomolecules. EVs are secreted from various cell types, and recent studies have shown that mesenchymal stem cell-derived EVs have therapeutic potential against immune and metabolic diseases. In this study, we investigated whether EVs from induced mesenchymal stem cells (iMSC-EVs) regulate AMPK signaling and lipid metabolism using cell-based studies and two different mouse models of NASH (methionine/choline-deficient diet-induced and ob/ob mice). Protein analysis revealed that iMSC-EVs carry cargo proteins with the potential to regulate lipid metabolism. iMSC-EVs inhibited free fatty acid release from adipose tissues by downregulating the activity of lipolytic genes in NASH. In addition, iMSC-EVs improved hepatic steatosis by modulating AMPK signaling, which plays essential role in metabolic homeostasis in the liver. Moreover, iMSC-EVs reduced CD36 expression, contributing to the blockade of free fatty acid transport to the liver of NASH mice. Finally, iMSC-EVs reduced inflammation, endoplasmic reticulum stress, and apoptosis while promoting hepatic regeneration of the NASH liver. In conclusion, iMSC-EVs can potentially serve as cell-free therapeutics for NASH owing to their multifaceted modality.
C1 [Kim, Jimin; Jeong, Seon-Yeong; Han, Sang-Deok; Park, Somi; Kim, Soo] Brexogen Inc, Brexogen Res Ctr, Seoul 05855, South Korea.
   [Kim, Tae Min] Seoul Natl Univ, Grad Sch Int Agr Technol, Pyeongchang 25354, Gangwon Do, South Korea.
   [Kim, Tae Min] Seoul Natl Univ, Inst Green Bio Sci & Technol, Pyeongchang 25354, Gangwon Do, South Korea.
C3 Seoul National University (SNU); Seoul National University (SNU)
RP Kim, TM (corresponding author), Seoul Natl Univ, Grad Sch Int Agr Technol, Pyeongchang 25354, Gangwon Do, South Korea.; Kim, TM (corresponding author), Seoul Natl Univ, Inst Green Bio Sci & Technol, Pyeongchang 25354, Gangwon Do, South Korea.
EM taemin21@snu.ac.kr
OI You, Haedeun/0009-0006-3622-4235
FU Korean Fund for Regenerative Medicine (KFRM) - Korean government (the
   Ministry of Science and ICT); Korean Fund for Regenerative Medicine
   (KFRM) - Korean government (Ministry of Health Welfare) [22C0610L1-11];
   National Research Foundation of Korea (NRF) - Korean government (MSIT)
   [2021R1A2C2093867]
FX This research was supported by the Korean Fund for Regenerative Medicine
   (KFRM) grant funded by the Korean government (the Ministry of Science
   and ICT, the Ministry of Health & Welfare) (22C0610L1-11) (to S.K. and
   T.M.K.) . This work was also supported by the National Research
   Foundation of Korea (NRF) Grant funded by the Korean government (MSIT)
   (2021R1A2C2093867) (to T.M.K.) .
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NR 86
TC 3
Z9 3
U1 0
U2 15
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0168-3659
EI 1873-4995
J9 J CONTROL RELEASE
JI J. Control. Release
PD DEC
PY 2023
VL 364
BP 297
EP 311
DI 10.1016/j.jconrel.2023.10.045
EA OCT 2023
PG 15
WC Chemistry, Multidisciplinary; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Pharmacology & Pharmacy
GA Y1FU8
UT WOS:001102804000001
PM 39491172
DA 2025-06-11
ER

PT J
AU Hammad, SM
   Lopes-Virella, MF
AF Hammad, Samar M.
   Lopes-Virella, Maria F.
TI Circulating Sphingolipids in Insulin Resistance, Diabetes and Associated
   Complications
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE sphingolipid; diabetes; obesity; insulin resistance; metabolic syndrome;
   diabetic kidney disease; cardiovascular disease; diabetic complications
ID CORONARY-ARTERY-DISEASE; LOW-DENSITY-LIPOPROTEIN; BETA-CELL APOPTOSIS;
   SPHINGOSINE 1-PHOSPHATE; SIGNAL-TRANSDUCTION; OXIDATIVE STRESS;
   SKELETAL-MUSCLE; SPHINGOSINE-1-PHOSPHATE CONTENT; MEDIATED ACTIVATION;
   ISLET AUTOIMMUNITY
AB Sphingolipids play an important role in the development of diabetes, both type 1 and type 2 diabetes, as well as in the development of both micro- and macro-vascular complications. Several reviews have been published concerning the role of sphingolipids in diabetes but most of the emphasis has been on the possible mechanisms by which sphingolipids, mainly ceramides, contribute to the development of diabetes. Research on circulating levels of the different classes of sphingolipids in serum and in lipoproteins and their importance as biomarkers to predict not only the development of diabetes but also of its complications has only recently emerged and it is still in its infancy. This review summarizes the previously published literature concerning sphingolipid-mediated mechanisms involved in the development of diabetes and its complications, focusing on how circulating plasma sphingolipid levels and the relative content carried by the different lipoproteins may impact their role as possible biomarkers both in the development of diabetes and mainly in the development of diabetic complications. Further studies in this field may open new therapeutic avenues to prevent or arrest/reduce both the development of diabetes and progression of its complications.
C1 [Hammad, Samar M.] Med Univ South Carolina, Dept Regenerat Med & Cell Biol, Charleston, SC 29425 USA.
   [Lopes-Virella, Maria F.] Med Univ South Carolina, Dept Med, Div Endocrinol Diabet & Med Genet, Charleston, SC 29425 USA.
   [Lopes-Virella, Maria F.] Ralph H Johnson VA Med Ctr, Charleston, SC 29425 USA.
C3 Medical University of South Carolina; Medical University of South
   Carolina; US Department of Veterans Affairs; Veterans Health
   Administration (VHA); Ralph H Johnson VA Medical Center
RP Hammad, SM (corresponding author), Med Univ South Carolina, Dept Regenerat Med & Cell Biol, Charleston, SC 29425 USA.; Lopes-Virella, MF (corresponding author), Med Univ South Carolina, Dept Med, Div Endocrinol Diabet & Med Genet, Charleston, SC 29425 USA.; Lopes-Virella, MF (corresponding author), Ralph H Johnson VA Med Ctr, Charleston, SC 29425 USA.
EM hammadsm@musc.edu; virellam@musc.edu
OI Hammad, Samar/0000-0002-1313-2542
FU NIH/NIDDK
FX No Statement Available
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NR 245
TC 17
Z9 17
U1 0
U2 6
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD SEP
PY 2023
VL 24
IS 18
AR 14015
DI 10.3390/ijms241814015
PG 34
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA AN8B1
UT WOS:001119225800001
PM 37762318
OA gold, Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Wang, X
   Xu, ZQ
   Chang, R
   Zeng, CC
   Zhao, YL
AF Wang, Xiao
   Xu, Zuqing
   Chang, Rong
   Zeng, Changchun
   Zhao, Yanli
TI High-Fructose Diet Induces Cardiac Dysfunction via Macrophage
   Recruitment in Adult Mice
SO JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS
LA English
DT Article
DE cardiac disease; cardiac hypertrophy; cardiac fibrosis; macrophage
   infiltration; inflammatory response
ID MONOCYTE CHEMOATTRACTANT PROTEIN-1; OXIDATIVE STRESS; CORN SYRUP;
   IN-VITRO; INFLAMMATION; HYPERTROPHY; APOPTOSIS; BEVERAGES; FIBROSIS;
   FAILURE
AB Cardiovascular diseases are the leading cause of death globally, including cardiac fibrosis, myocardial infarction, cardiac hypertrophy, and heart failure. High fat/ fructose induces metabolic syndrome, hypertension and obesity, which contributes to cardiac hypertrophy and fibrosis. Excessive fructose intake accelerates inflammation in different organs and tissues, and molecular and cellular mechanisms of organ and tissue injury have been demonstrated. However, the mechanisms of cardiac inflammation have not been fully documented in high-fructose diet. This study shows that there are significantly increased in cardiomyocytes size and relative wall thickness of LV in high-fructose fed adult mice. With echocardiographic analysis of cardiac function, the ejection fraction (EF%) and fractional shortening (FS%) are significantly reduced at 12 weeks after 60% high-fructose diet. The mRNA and protein levels of MCP-1 are notably increased in high-fructose treated HL-1 and primary cardiomyocyte respectively. Also, the increased protein level of MCP-1 has been detected in vivo mouse model after 12 weeks feeding, resulting in the production of pro-inflammatory makers, pro-fibrotic genes expression, and macrophage infiltration. These data demonstrate that high-fructose intake induces cardiac inflammation via macrophage recruitment in cardiomyocyte, which contributes to impair cardiac function.
C1 [Wang, Xiao; Xu, Zuqing; Chang, Rong; Zeng, Changchun; Zhao, Yanli] Guangdong Med Univ, Shenzhen Longhua Dist Cent Hosp, Dept Ultrasound, Shenzhen, Peoples R China.
   [Wang, Xiao; Chang, Rong; Zhao, Yanli] Guangdong Med Univ, Shenzhen Longhua Dist Cent Hosp, Dept Cardiovasc Med, Shenzhen, Peoples R China.
   [Xu, Zuqing; Zhao, Yanli] Guangdong Med Univ, Shenzhen Longhua Dist Cent Hosp, Dept Intens Care Unit, Shenzhen, Peoples R China.
   [Zeng, Changchun; Zhao, Yanli] Guangdong Med Univ, Shenzhen Longhua Dist Cent Hosp, Dept Med Lab, Shenzhen, Peoples R China.
   [Zhao, Yanli] Guangdong Med Univ, Shenzhen Longhua Dist Cent Hosp, Dept Med Lab, Shenzhen 518110, Peoples R China.
C3 Shenzhen Longhua District Central Hospital; Guangdong Medical
   University; Shenzhen Longhua District Central Hospital; Guangdong
   Medical University; Shenzhen Longhua District Central Hospital;
   Guangdong Medical University; Guangdong Medical University; Shenzhen
   Longhua District Central Hospital; Shenzhen Longhua District Central
   Hospital; Guangdong Medical University
RP Zhao, YL (corresponding author), Guangdong Med Univ, Shenzhen Longhua Dist Cent Hosp, Dept Med Lab, Shenzhen 518110, Peoples R China.
EM yanlizhao2015@126.com
RI zeng, changchun/AAE-5532-2020
OI Zhao, Yanli/0000-0001-9445-7666
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NR 46
TC 9
Z9 9
U1 4
U2 11
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1074-2484
EI 1940-4034
J9 J CARDIOVASC PHARM T
JI J. Cardiovasc. Pharmacol. Ther.
PY 2023
VL 28
AR 10742484231162249
DI 10.1177/10742484231162249
PG 11
WC Cardiac & Cardiovascular Systems; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Pharmacology & Pharmacy
GA C2WA5
UT WOS:000960569200001
PM 36995038
OA gold
DA 2025-06-11
ER

PT J
AU Macvanin, MT
   Rizzo, M
   Radovanovic, J
   Sonmez, A
   Paneni, F
   Isenovic, ER
AF Macvanin, Mirjana T.
   Rizzo, Manfredi
   Radovanovic, Jelena
   Sonmez, Alper
   Paneni, Francesco
   Isenovic, Esma R.
TI Role of Chemerin in Cardiovascular Diseases
SO BIOMEDICINES
LA English
DT Review
DE chemerin; cardiovascular disease; chemerin receptors; adipokine;
   inflammation; endothelial dysfunction; chemerin-targeting therapeutic
   agents
ID VASCULAR SMOOTH-MUSCLE; CORONARY-ARTERY-DISEASE; EARLY ATHEROSCLEROTIC
   CHANGES; ADIPOKINE CHEMERIN; OXIDATIVE STRESS; INSULIN-RESISTANCE; SERUM
   CHEMERIN; METABOLIC SYNDROME; CIRCULATING CHEMERIN; CONSENSUS STATEMENT
AB (1) Background: Obesity is closely connected to the pathophysiology of cardiovascular diseases (CVDs). Excess fat accumulation is associated with metabolic malfunctions that disrupt cardiovascular homeostasis by activating inflammatory processes that recruit immune cells to the site of injury and reduce nitric oxide levels, resulting in increased blood pressure, endothelial cell migration, proliferation, and apoptosis. Adipose tissue produces adipokines, such as chemerin, that may alter immune responses, lipid metabolism, vascular homeostasis, and angiogenesis. (2) Methods: We performed PubMed and MEDLINE searches for articles with English abstracts published between 1997 (when the first report on chemerin identification was published) and 2022. The search retrieved original peer-reviewed articles analyzed in the context of the role of chemerin in CVDs, explicitly focusing on the most recent findings published in the past five years. (3) Results: This review summarizes up-to-date findings related to mechanisms of chemerin action, its role in the development and progression of CVDs, and novel strategies for developing chemerin-targeting therapeutic agents for treating CVDs. (4) Conclusions: Extensive evidence points to chemerin's role in vascular inflammation, angiogenesis, and blood pressure modulation, which opens up exciting perspectives for developing chemerin-targeting therapeutic agents for the treatment of CVDs.
C1 [Macvanin, Mirjana T.; Radovanovic, Jelena; Isenovic, Esma R.] Univ Belgrade, VINCA Inst Nucl Sci, Natl Inst Republ Serbia, Dept Radiobiol & Mol Genet, Belgrade 11000, Serbia.
   [Rizzo, Manfredi] Univ Palermo UNIPA, Dept Internal Med & Med Specialties DIMIS, I-90128 Palermo, Italy.
   [Sonmez, Alper] Univ Hlth Sci, Gulhane Sch Med, Dept Endocrinol & Metab, TR-34668 Ankara, Turkey.
   [Paneni, Francesco] Univ Hosp Zurich, Univ Heart Ctr, CH-8091 Zurich, Switzerland.
   [Paneni, Francesco] Univ Hosp Zurich, Univ Zurich, Ctr Translat & Expt Cardiol CTEC, Dept Cardiol, Wagistr 12, CH-8952 Schlieren, Switzerland.
C3 University of Belgrade; University of Palermo; University of Health
   Sciences Turkey; Gulhane Military Medical Academy; University of Zurich;
   University Zurich Hospital; University of Zurich; University Zurich
   Hospital
RP Paneni, F (corresponding author), Univ Hosp Zurich, Univ Heart Ctr, CH-8091 Zurich, Switzerland.; Paneni, F (corresponding author), Univ Hosp Zurich, Univ Zurich, Ctr Translat & Expt Cardiol CTEC, Dept Cardiol, Wagistr 12, CH-8952 Schlieren, Switzerland.
EM francesco.paneni@uzh.ch
RI Isenovic, Esma/D-3017-2009; Radovanović, Jelena/AAD-6068-2021; RIZZO,
   MANFREDI/GZL-0551-2022; Sonmez, Alper/H-8588-2019; Macvanin,
   Mirjana/IUM-9308-2023
OI Sonmez, Alper/0000-0002-9309-7715; Isenovic, Esma/0000-0002-0012-2636;
   Radovanovic, Jelena/0000-0002-3005-7943; Paneni,
   Francesco/0000-0001-6483-7844; Macvanin, Mirjana/0000-0003-2811-9428;
   RIZZO, Manfredi/0000-0002-9549-8504
FU Ministry of Education, Science, and Technological Development of the
   Republic of Serbia;  [451-03-9/2021-14/200017]
FX The work is funded by the Ministry of Education, Science, and
   Technological Development of the Republic of Serbia, Contract
   No#451-03-9/2021-14/200017.
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NR 188
TC 22
Z9 25
U1 3
U2 25
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2227-9059
J9 BIOMEDICINES
JI Biomedicines
PD NOV
PY 2022
VL 10
IS 11
AR 2970
DI 10.3390/biomedicines10112970
PG 20
WC Biochemistry & Molecular Biology; Medicine, Research & Experimental;
   Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Research & Experimental Medicine;
   Pharmacology & Pharmacy
GA 6V8TM
UT WOS:000895312800001
PM 36428537
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Dastgerdi, AH
   Rad, MG
   Soltani, N
AF Dastgerdi, Azadehalsadat Hosseini
   Rad, Mahtab Ghanbari
   Soltani, Nepton
TI The therapeutic effects of magnesium in insulin secretion and insulin
   resistance
SO ADVANCED BIOMEDICAL RESEARCH
LA English
DT Review
DE Diabetes; glucose; insulin resistance; magnesium
ID OXIDATIVE STRESS; DOUBLE-BLIND; NONDIABETIC SUBJECTS;
   CO-SUPPLEMENTATION; DIABETES-MELLITUS; GLYCEMIC CONTROL; GLUCOSE;
   INFLAMMATION; GENE; SENSITIVITY
AB Insulin resistance (IR) is a chronic pathological condition that is related to reduce the rates of glucose uptake, especially in the liver, muscle, and adipose tissue as target tissues. Metabolic syndrome and type 2 diabetes mellitus can occur following progression of the disease. The majority of prior research has applied that some cations such as magnesium (Mg2+) have important physiological role in insulin metabolism. Mg2+ is the fourth most abundant mineral in the human body that gets involved as a cofactor of various enzymes in several metabolic events, such as carbohydrate oxidation, and it has a fundamental role in glucose transporting mechanism of the cell membrane. This cation has numerous duties in the human body such as regulation of insulin secretion in pancreatic beta-cells and phosphorylation of the insulin receptors in target cells and also gets involved in other downstream signal kinases as intracellular cation. On this basis, intracellular Mg2+ balancing is vital for adequate carbohydrate metabolism. This paper summarizes the present knowledge about the therapeutic effects of Mg2+ in reducing IR in liver, muscle, and pancreases with different mechanisms. For this, the search was performed in Google Scholar, PubMed, Scopus, and Web of Science by insulin resistance, skeletal muscle, liver, pancreases, magnesium, Mg2+, and inflammation keywords.
C1 [Dastgerdi, Azadehalsadat Hosseini; Rad, Mahtab Ghanbari; Soltani, Nepton] Isfahan Univ Med Sci, Sch Med, Dept Physiol, Esfahan, Iran.
C3 Isfahan University of Medical Sciences
RP Soltani, N (corresponding author), Isfahan Univ Med Sci, Sch Med, Dept Physiol, Esfahan, Iran.
EM neptun.soltani@med.mui.ac.ir
OI hosseini dastgerdi, azadehalsadat/0000-0001-9555-1769
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NR 92
TC 10
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U1 0
U2 9
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, Maharashtra, INDIA
SN 2277-9175
J9 ADV BIOMED RES-INDIA
JI Adv. Biomed. Res.
PD JAN-DEC
PY 2022
VL 11
IS 1
DI 10.4103/abr.abr_366_21
PG 11
WC Medicine, Research & Experimental
WE Emerging Sources Citation Index (ESCI)
SC Research & Experimental Medicine
GA 3B0EU
UT WOS:000827624100009
PM 35982863
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Santana-Garrido, A
   Reyes-Goya, C
   Milla-Navarro, S
   de la Villa, P
   André, H
   Vazquez, CM
   Mate, A
AF Santana-Garrido, Alvaro
   Reyes-Goya, Claudia
   Milla-Navarro, Santiago
   de la Villa, Pedro
   Andre, Helder
   Vazquez, Carmen M.
   Mate, Alfonso
TI Anti-Inflammatory Action of Dietary Wild Olive (Acebuche) Oil in the
   Retina of Hypertensive Mice
SO FOODS
LA English
DT Article
DE acebuche; arterial hypertension; inflammation; olive oil; retina; wild
   olive tree
ID MEDITERRANEAN DIET; DIABETIC-RETINOPATHY; METABOLIC SYNDROME; OXIDATIVE
   STRESS; IN-VIVO; INFLAMMATION; HYDROXYTYROSOL; ACTIVATION; PROTECTS;
   IMMUNITY
AB Inflammation plays a crucial role in the course of eye diseases, including many vascular retinopathies. Although olive oil is known to have beneficial effects against inflammatory processes, there is no information available on the anti-inflammatory potential of the wild olive tree (namely, acebuche (ACE) for the primitive Spanish lineages). Here we investigate the anti-inflammatory effects of ACE oil in the retina of a mouse model of arterial hypertension, which was experimentally induced by administration of L-NAME (NG-nitro-L-arginine-methyl-ester). The animals were fed supplements of ACE oil or extra virgin olive oil (EVOO, for comparative purposes). Retinal function was assessed by electroretinography (ERG), and different inflammation-related parameters were measured in the retina and choroid. Besides significant prevention of retinal dysfunction shown in ERG recordings, ACE oil-enriched diet upregulated the expression of the anti-inflammatory markers PPAR gamma, PPAR alpha and IL-10, while reducing that of major proinflammatory biomarkers, IL-1 beta, IL-6, TNF-alpha and COX-2. This is the first report to highlight the anti-inflammatory properties of an ACE oil-enriched diet against hypertension-related retinal damage. Noteworthy, dietary supplementation with ACE oil yielded better results compared to a reference EVOO.
C1 [Santana-Garrido, Alvaro; Reyes-Goya, Claudia; Vazquez, Carmen M.; Mate, Alfonso] Univ Seville, Fac Farm, Dept Fisiol, Seville 41012, Spain.
   [Santana-Garrido, Alvaro; Vazquez, Carmen M.; Mate, Alfonso] Univ Seville, CSIC, Epidemiol Clin & Riesgo Cardiovasc, Inst Biomed Sevilla IBIS,Hosp Univ Virgen Rocio, Seville 41013, Spain.
   [Milla-Navarro, Santiago; de la Villa, Pedro] Univ Alcala, Dept Syst Biol, Madrid 28871, Spain.
   [de la Villa, Pedro] Inst Ramon y Cajal Invest Sanitaria IRYCIS, Madrid 28034, Spain.
   [Andre, Helder] Karolinska Inst, St Erik Eye Hosp, Dept Clin Neurosci, S-11282 Stockholm, Sweden.
C3 University of Sevilla; Virgen del Rocio University Hospital; Consejo
   Superior de Investigaciones Cientificas (CSIC); University of Sevilla;
   CSIC-JA-USE - Instituto de Biomedicina de Sevilla (IBIS); Universidad de
   Alcala; Karolinska Institutet
RP Mate, A (corresponding author), Univ Seville, Fac Farm, Dept Fisiol, Seville 41012, Spain.; Mate, A (corresponding author), Univ Seville, CSIC, Epidemiol Clin & Riesgo Cardiovasc, Inst Biomed Sevilla IBIS,Hosp Univ Virgen Rocio, Seville 41013, Spain.
EM asgarrido@us.es; crgoya@us.es; santiago.milla@edu.uah.es;
   pedro.villa@uah.es; helder.andre@ki.se; vazquez@us.es; mate@us.es
RI Reyes-Goya, Claudia/KOC-4578-2024; Garrido, Alvaro/AAU-8611-2021; Andre,
   Helder/AAC-5220-2019; Milla-Navarro, Santiago/AAH-5899-2021; VAZQUEZ,
   CARMEN/K-7058-2014; DE LA VILLA, PEDRO/G-2322-2016; Mate,
   Alfonso/G-7418-2012
OI VAZQUEZ, CARMEN/0000-0002-2999-3582; DE LA VILLA,
   PEDRO/0000-0001-9856-6616; Mate, Alfonso/0000-0002-2719-8825; Santana
   Garrido, Alvaro/0000-0002-9469-3850; Milla-Navarro,
   Santiago/0000-0002-6947-5034; Reyes-Goya, Claudia/0000-0002-1621-5335;
   Andre, Helder/0000-0002-2926-2376
FU Agencia Estatal de Investigacion, Ministerio de Ciencia e Innovacion,
   Gobierno de Espana [PID2019-109002RB-I00/AEI/10.13039/501100011033];
   Consejeria de Economia, Conocimiento, Empresas y Universidad, Junta de
   Andalucia [2020/275, 2021/188, CTS-584]; VI PPIT Universidad de Sevilla
   [2020/1163]; Ministerio de Universidades [FPU17/03465]; Ministerio de
   Ciencia e Innovacion, Ayudas para la Promocion de Empleo Joven e
   Implantacion de la Garantia Juvenil en I + D+i 2017-2020
   [PEJ2018-004474-A]
FX This research and the APC were funded by Agencia Estatal de
   Investigacion, Ministerio de Ciencia e Innovacion, Gobierno de Espana
   (PID2019-109002RB-I00/AEI/10.13039/501100011033); Consejeria de
   Economia, Conocimiento, Empresas y Universidad, Junta de Andalucia
   (2020/275 and 2021/188; CTS-584); and VI PPIT Universidad de Sevilla
   (IV.7 Ayuda Suplementaria a Grupos de Investigacion por captacion de
   fondos en las convocatorias de proyectos de investigacion del Plan
   Estatal, 2020/1163). AS is recipient of an FPU predoctoral fellowship
   from Ministerio de Universidades (FPU17/03465). CR-G was supported by
   Ministerio de Ciencia e Innovacion, Ayudas para la Promocion de Empleo
   Joven e Implantacion de la Garantia Juvenil en I + D+i 2017-2020
   (PEJ2018-004474-A).
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NR 76
TC 9
Z9 9
U1 0
U2 8
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2304-8158
J9 FOODS
JI Foods
PD SEP
PY 2021
VL 10
IS 9
AR 1993
DI 10.3390/foods10091993
PG 18
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA UV8ZD
UT WOS:000699758200001
PM 34574102
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Ahmad, S
   Khan, A
   Batool, Z
   Mehmood, MH
   Khaliq, S
   Tabassum, S
   Rajput, SN
   Haider, S
AF Ahmad, Saara
   Khan, Asra
   Batool, Zehra
   Mehmood, Malik Hassan
   Khaliq, Saima
   Tabassum, Saiqa
   Rajput, Shafiqa Naeem
   Haider, Saida
TI Medicinal effects of saffron and chamomile on diabetes mellitus and
   associated hyperlipidemia and memory impairment
SO PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES
LA English
DT Article
DE Chamomile; saffron; diabetes mellitus; hyperlipidemia; cognitive
   impairment; oxidative stress
ID GLYCEMIC CONTROL; TYPE-2; TEA
AB Diabetes mellitus is a multifactorial metabolic syndrome, in which FDA approved treatments have their own limitations and drawbacks. Therefore, herbal alternatives have recently garnered attention for their effectiveness against diabetes. Herbs saffron and chamomile are renowned for their potent benefits. The present study was designed to observe their effects separately as well as in combination on blood glucose, lipids and antioxidant profile along with memory in diabetic animal model. Fifty male Sprague-dawley rats of 200g +/- 20g weight were divided into healthy and diabetic controls while the test groups received methanolic extract of saffron (10 mg/kg), chamomile (30 mg/kg) and combined extract of saffron and chamomile (5mg/kg and 15mg/kg, respectively) over a period of two weeks. It was observed that there were considerable anti-diabetic and anti-hyperlipidemic effects in all treatment groups with modulation of body weight especially in combined saffron and chamomile administered group. Likewise, the antioxidant profile showed significantly decreased MDA levels with reduced SOD activity in all test groups particularly in the combined group with significant improvement in cognition. The considerable results of combined group showed herbal synergy at half dose and bring forth a cost-effective treatment for diabetes and associated disorders than treatment with a single herb.
C1 [Ahmad, Saara; Khan, Asra; Rajput, Shafiqa Naeem] Aga Khan Univ, Dept Biol & Biomed Sci, Karachi, Pakistan.
   [Batool, Zehra] Univ Karachi, Int Ctr Chem & Biol Sci, Dr Panjwani Ctr Mol Med & Drug Res, Karachi, Pakistan.
   [Mehmood, Malik Hassan] Govt Coll Univ, Fac Pharmaceut Sci, Dept Pharmacol, Faisalabad, Pakistan.
   [Khaliq, Saima] Fed Urdu Univ Arts Sci & Technol, Dept Biochem, Karachi, Pakistan.
   [Tabassum, Saiqa] Shaheed Zulfiqar Ali Bhutto Univ, Dept Biochem, Karachi, Pakistan.
   [Haider, Saida] Univ Karachi, Dept Biochem, Karachi, Pakistan.
C3 Aga Khan University; University of Karachi; Government College
   University Faisalabad; Federal Urdu University of Arts Science &
   Technology; University of Karachi
RP Ahmad, S (corresponding author), Aga Khan Univ, Dept Biol & Biomed Sci, Karachi, Pakistan.
EM saara_ahmad@hotmail.com
RI TABASSUM, DR. SAIQA/C-5737-2018; Haider, Saida/C-5741-2018; Mehmood, Dr
   Malik Hassan/KCJ-4885-2024; Batool, Zehra/C-5614-2018
OI Mehmood, Malik Hassan/0000-0002-9959-1458; Rajput, Shafiqa
   Naeem/0000-0002-1846-2671
FU Dean's Grant, Aga Khan University, Karachi, Pakistan
FX This work was supported by the Dean's Grant, Aga Khan University,
   Karachi, Pakistan. We are thankful to the faculty and staff of
   Biological and Biomedical Sciences, Aga Khan University for their
   support during research of the project.
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NR 36
TC 7
Z9 7
U1 0
U2 6
PU UNIV KARACHI
PI KARACHI
PA UNIV CAMPUS, FAC PHARMACY, KARACHI, 75270, PAKISTAN
SN 1011-601X
J9 PAK J PHARM SCI
JI Pak. J. Pharm. Sci.
PD MAY
PY 2020
VL 33
IS 3
SU S
BP 1191
EP 1198
DI 10.36721/PJPS.2020.33.3.SUP.1191-1198.1
PG 8
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA MV2DC
UT WOS:000556171900002
DA 2025-06-11
ER

PT J
AU Emini-Sadiku, M
   Car, N
   Begolli, L
   Blaslov, K
   Haliti, E
   Bahtiri, E
AF Emini-Sadiku, Merita
   Car, Nikica
   Begolli, Luljeta
   Blaslov, Kristina
   Haliti, Edmond
   Bahtiri, Elton
TI The differential influence of glimepiride and glibenclamide on insulin
   resistance and adiponectin levels in patients with type 2 diabetes
SO ENDOCRINE JOURNAL
LA English
DT Article
DE Insulin resistance; Adiponectin Glimepiride; Glibenclamide
ID OXIDATIVE STRESS; OBESITY; ASSOCIATION; ADIPOCYTES; PLASMA; IMPACT
AB Several studies have demonstrated the decreased insulin resistance (IR) in persons with type 2 diabetes mellitus (T2DM) treated with glimepiride. Those suggest this might be associated with observed higher concentrations of adiponectin. We assessed if there is a difference in IR and metabolic syndrome components between glimepiride and glibenclamide treatment as well as adiponectin concentration in T2DM. Our research observed 20 T2DM patients treated with glibenclamid and 20 switched to glimepiride (n = 20) treatment for 24 weeks. Anthropometric measurements and laboratory analysis were performed at the beginning and at the end of treatment while IR was accessed by homeostasis model assessment of insulin resistance (HOMA-IR). The glimepiride group revealed better glycaemic control compared to glibenclamide group. Moreover, the adiponectin concentration increased (23.9 +/- 17.3 to 29.1 +/- 12.2 ng/mL, p = 0.087) whereas it decreased in the glibenclamide group (34.3 +/- 22.6 to 20.3 +/- 11.3 ng/mL, p= 0.011) following 24 weeks of treatment. The serum adiponectin and HOMA-IR were inversely correlated within the group of glibenclamide (r = -0.667, p = 0.009). The present study demonstrates that glimepiride might have beneficial effect on IR compared to glibenclamide, as suggested. However, this observation needs further study investigation among other formulations of SU.
C1 [Emini-Sadiku, Merita; Haliti, Edmond] Univ Prishtina, Fac Med, Dept Internal Dis, Prishtine 10000, Kosovo.
   [Emini-Sadiku, Merita] Univ Clin Ctr Kosovo, Clin Endocrinol, Pristina 10000, Kosovo.
   [Car, Nikica] Univ Hosp Merkur, Univ Clin Diabet Endocrinol & Metab Vuk Vrhovac, Zagreb 10000, Croatia.
   [Begolli, Luljeta] Univ Prishtina, Fac Med, Inst Biochem, Pristina 10000, Kosovo.
   [Blaslov, Kristina] Univ Clin Hosp Ctr Sestre Milosrdnicev, Dept Endocrinol Diabet & Metab Dis Mladen Sekso, Zagreb 10000, Croatia.
   [Haliti, Edmond] Univ Clin Ctr Kosovo, Clin Cardiol, Pristina 10000, Kosovo.
   [Bahtiri, Elton] Univ Prishtina, Fac Med, Dept Pharmacol, Pristina 10000, Kosovo.
C3 Universiteti i Prishtines; Universiteti i Prishtines
RP Haliti, E (corresponding author), Univ Clin Ctr Kosovo, Clin Cardiol, Pristina 10000, Kosovo.
EM edihal@yahoo.com
RI Emini Sadiku, Merita/V-6205-2017; Bahtiri, Elton/Z-2948-2019
OI Bahtiri, Elton/0000-0001-7519-3925
FU Ministry of Science and Education of Kosovo
FX None of the authors have any potential conflicts of interest associated
   with this research. The study was partially supported by Grant of
   Ministry of Science and Education of Kosovo.
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NR 24
TC 6
Z9 6
U1 1
U2 5
PU JAPAN ENDOCRINE SOC
PI KYOTO
PA 75  YANAGINOBANBA NISHIIRU-MASUYA-CHO, SANJOU-DORI, NAKAGYOU-KU, KYOTO,
   604-8111, JAPAN
SN 0918-8959
EI 1348-4540
J9 ENDOCR J
JI Endocr. J.
PY 2019
VL 66
IS 10
BP 915
EP 921
DI 10.1507/endocrj.EJ18-0493
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA JQ7TX
UT WOS:000499144200008
PM 31292311
OA gold
DA 2025-06-11
ER

PT J
AU Finamore, A
   Palmery, M
   Bensehaila, S
   Peluso, I
AF Finamore, Alberto
   Palmery, Maura
   Bensehaila, Sarra
   Peluso, Ilaria
TI Antioxidant, Immunomodulating, and Microbial-Modulating Activities of
   the Sustainable and Ecofriendly Spirulina
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Review
ID ARTHROSPIRA-PLATENSIS SUPPLEMENTATION; HUMAN-IMMUNODEFICIENCY-VIRUS;
   LACTIC-ACID BACTERIA; OXIDATIVE STRESS; C-PHYCOCYANIN; IMMUNE-SYSTEM;
   IN-VITRO; ANTIBACTERIAL ACTIVITY; CHLORELLA-VULGARIS; METABOLIC SYNDROME
AB The highly nutritional and ecofriendly Spirulina (Arthrospira platensis) has hypolipidemic, hypoglycemic, and antihypertensive properties. Spirulina contains functional compounds, such as phenolics, phycocyanins, and polysaccharides, with antioxidant, anti-inflammatory, and immunostimulating effects. Studies conducted on Spirulina suggest that it is safe in healthy subjects, but attitude to eating probably affects the acceptability of Spirulina containing foods. Although the antioxidant effect of Spirulina is confirmed by the intervention studies, the concerted modulation of antioxidant and inflammatory responses, suggested by in vitro and animal studies, requires more confirmation in humans. Spirulina supplements seem to affect more effectively the innate immunity, promoting the activity of natural killer cells. The effects on cytokines and on lymphocytes' proliferation depend on age, gender, and body weight differences. In this context, ageing and obesity are both associated with chronic low grade inflammation, immune impairment, and intestinal dysbiosis. Microbial-modulating activities have been reported in vitro, suggesting that the association of Spirulina and probiotics could represent a new strategy to improve the growth of beneficial intestinal microbiota. Although Spirulina might represent a functional food with potential beneficial effects on human health, the human interventions used only supplements. Therefore, the effect of food containing Spirulina should be evaluated in the future.
C1 [Finamore, Alberto; Peluso, Ilaria] Council Agr Res & Econ CREA NUT, Ctr Nutr, Via Ardeatina 546, I-00178 Rome, Italy.
   [Palmery, Maura] Sapienza Univ Rome, Dept Physiol & Pharmacol V Erspamer, Rome, Italy.
   [Bensehaila, Sarra] Univ Hassiba Benbouali, Dept Biol, Lab Nat & Local Bioresources, Fac Sci, Chlef 02000, Algeria.
C3 Consiglio per la Ricerca in Agricoltura e L'analisi Dell'economia
   Agraria (CREA); Sapienza University Rome; Universite Hassiba Ben Bouali
   de Chlef
RP Peluso, I (corresponding author), Council Agr Res & Econ CREA NUT, Ctr Nutr, Via Ardeatina 546, I-00178 Rome, Italy.
EM i.peluso@tiscali.it
RI Peluso, Ilaria/ABE-3399-2021; Finamore, Alberto/AAP-6163-2020; Peluso,
   Ilaria/A-8023-2018
OI Peluso, Ilaria/0000-0002-6210-5241
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TC 168
Z9 184
U1 4
U2 72
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PY 2017
VL 2017
AR 3247528
DI 10.1155/2017/3247528
PG 14
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA EK7QF
UT WOS:000394119600001
PM 28182098
OA Green Submitted, Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Yang, QL
   Zhao, FF
   Hu, LL
   Bai, R
   Zhang, N
   Yao, GD
   Sun, YP
AF Yang, Qingling
   Zhao, Feifei
   Hu, Linli
   Bai, Rui
   Zhang, Nan
   Yao, Guidong
   Sun, Yingpu
TI Effect of paternal overweight or obesity on IVF treatment outcomes and
   the possible mechanisms involved
SO SCIENTIFIC REPORTS
LA English
DT Article
ID BODY-MASS INDEX; IN-VITRO FERTILIZATION; DIET-INDUCED OBESITY; TELOMERE
   LENGTH; OXIDATIVE STRESS; SEMEN QUALITY; METABOLIC SYNDROME; GERM-CELLS;
   IMPACT; SPERMATOZOA
AB Leukocyte telomere lengths (LTLs) are shorter in obese compared with normal weight people. However, it is not known whether sperm telomere length (STL) is related to obesity. The aim of the study was to evaluate the impact of men's body mass index (BMI) on STL, embryo quality, and clinical outcomes in couples undergoing IVF. In total, 651 couples were recruited, including 345 men with a normal BMI and 306 men with an overweight BMI (normal BMI group: 20-25 kg/m(2); overweight BMI group: >28 kg/m(2)). We found that couples with male's BMI over 28 kg/m(2) exhibited a significantly lower fertilization rate, good-quality embryo rate and clinical pregnancy rate compared to their normal BMI counterparts. The mean STL in the overweight BMI group was also significantly shorter than that of the normal BMI group. The results also showed that individuals with higher BMI had higher ROS (Reactive oxygen species) content and sperm DNA fragmentation rate when compared with normal BMI individuals. Mitochondrial activity was also lower in the overweight BMI group than in the normal BMI group. This is the first report to find that STL is shorter in overweight/obese men, which may account for their poorer treatment outcomes in IVF cycles.
C1 [Yang, Qingling; Zhao, Feifei; Hu, Linli; Bai, Rui; Zhang, Nan; Yao, Guidong; Sun, Yingpu] Zhengzhou Univ, Reprod Med Ctr, Affiliated Hosp 1, Zhengzhou, Peoples R China.
C3 Zhengzhou University
RP Sun, YP (corresponding author), Zhengzhou Univ, Reprod Med Ctr, Affiliated Hosp 1, Zhengzhou, Peoples R China.
EM syp2008@vip.sina.com
RI Yang, Qingling/AAS-7436-2020
FU National Natural Science Foundation of China [31271605, 31471404];
   National Science Foundation for Young Scientists of China [31401274];
   Youth Innovation Fund of the First Affiliated Hospital of Zhengzhou
   University
FX We would like to thank all the patients who participated in this study.
   This work was funded by grants from the National Natural Science
   Foundation of China (Grants 31271605 and 31471404 to Yingpu Sun),
   National Science Foundation for Young Scientists of China (Grant
   31401274 to Qingling Yang), and the Youth Innovation Fund of the First
   Affiliated Hospital of Zhengzhou University (to Qingling Yang).
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NR 54
TC 36
Z9 43
U1 0
U2 22
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD JUL 14
PY 2016
VL 6
AR 29787
DI 10.1038/srep29787
PG 7
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA DR0CD
UT WOS:000379574700001
PM 27412918
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Holmes, A
   Coppey, LJ
   Davidson, EP
   Yorek, MA
AF Holmes, Amey
   Coppey, Lawrence J.
   Davidson, Eric P.
   Yorek, Mark A.
TI Rat Models of Diet-Induced Obesity and High Fat/Low Dose Streptozotocin
   Type 2 Diabetes: Effect of Reversal of High Fat Diet Compared to
   Treatment with Enalapril or Menhaden Oil on Glucose Utilization and
   Neuropathic Endpoints
SO JOURNAL OF DIABETES RESEARCH
LA English
DT Article
ID ANGIOTENSIN-CONVERTING-ENZYME; NERVE-CONDUCTION VELOCITY;
   INSULIN-RESISTANCE; NEUTRAL ENDOPEPTIDASE; PERIPHERAL NEUROPATHY; NEURAL
   COMPLICATIONS; METABOLIC SYNDROME; ACE-INHIBITOR; INFLAMMATION; EXERCISE
AB We examined whether reversal of high fat diet, stimulating weight loss, compared to two treatments previously shown to have beneficial effects, could improve glucose utilization and peripheral neuropathy in animal models of obesity and type 2 diabetes. Rats were fed a high fat diet and treated with a low dose of streptozotocin to create models of diet induced obesity or type 2 diabetes, respectively. Afterwards, rats were transferred to a normal diet or treated with enalapril or dietary enrichment with menhaden oil for 12 weeks. Obesity and to a greater extent type 2 diabetes were associated with impaired glucose utilization and peripheral neuropathy. Placing obese rats on a normal diet improved glucose utilization. Steatosis but not peripheral neuropathy was improved after placing obese or diabetic rats on a normal diet. Treating obese and diabetic rats with enalapril or a menhaden oil enriched diet generally improved peripheral neuropathy endpoints. In summary, dietary improvement with weight loss in obese or type 2 diabetic rats was not sufficient to correct peripheral neuropathy. These results further stress the need for discovery of a comprehensive treatment for peripheral neuropathy.
C1 [Holmes, Amey; Yorek, Mark A.] Dept Vet Affairs Iowa City Hlth Care Syst, Iowa City, IA 52246 USA.
   [Coppey, Lawrence J.; Davidson, Eric P.; Yorek, Mark A.] Univ Iowa, Dept Internal Med, Iowa City, IA 52242 USA.
   [Yorek, Mark A.] Univ Iowa, Fraternal Order Eagles Diabet Res Ctr, Iowa City, IA 52242 USA.
C3 US Department of Veterans Affairs; Veterans Health Administration (VHA);
   Iowa City VA Health Care System; University of Iowa; University of Iowa
RP Yorek, MA (corresponding author), Dept Vet Affairs Iowa City Hlth Care Syst, Iowa City, IA 52246 USA.
EM mark-yorek@uiowa.edu
RI Yorek, Mark/AAC-3136-2021
OI Yorek, Mark/0000-0001-7737-5554
FU Department of Veterans Affairs, Veterans Health Administration, Office
   of Research and Development; Biomedical Laboratory Research and
   Development [BX001680-01]; Rehabilitation Research and Development
   [RX000889-01]
FX This material is based upon work supported by the Department of Veterans
   Affairs, Veterans Health Administration, Office of Research and
   Development, Biomedical Laboratory Research and Development
   (BX001680-01), and Rehabilitation Research and Development
   (RX000889-01).
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NR 42
TC 45
Z9 46
U1 0
U2 6
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2314-6745
EI 2314-6753
J9 J DIABETES RES
JI J. Diabetes Res.
PY 2015
VL 2015
AR 307285
DI 10.1155/2015/307285
PG 8
WC Endocrinology & Metabolism; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Research & Experimental Medicine
GA CM6SE
UT WOS:000357819300001
PM 26229968
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Eshraghian, A
   Jahromi, AH
AF Eshraghian, Ahad
   Jahromi, Alireza Hamidian
TI Non-alcoholic fatty liver disease and thyroid dysfunction: A systematic
   review
SO WORLD JOURNAL OF GASTROENTEROLOGY
LA English
DT Review
DE Non alcoholic fatty liver disease; Thyroid dysfunction; Hypothyroidism;
   Non alcoholic steatohepatitis; Risk factor; Pathophysiology
ID GROWTH-FACTOR 21; METABOLIC SYNDROME; LIPID-PEROXIDATION; HEPATIC
   STEATOSIS; OXIDATIVE STRESS; SUBCLINICAL HYPOTHYROIDISM; INSULIN
   SENSITIVITY; ANTIOXIDANT STATUS; RISK-FACTORS; FGF21 LEVELS
AB Thyroid hormones are totally involved in the regulation of body weight, lipid metabolism, and insulin resistance. Therefore it is anticipated that thyroid hormones may have a role in the pathogenesis of non alcoholic fatty liver disease (NAFLD) and non alcoholic steatohepatitis (NASH). In this study, we reviewed the current literature on the association between thyroid dysfunction and NAFLD/NASH. A search for English language medical literature reporting an association between thyroid dysfunction and NAFLD/NASH in humans was conducted across PubMed, ISI Web of Science, and Scopus in August, 2013. Out of 140 studies initially identified through the search, 11 relevant articles were included in the final review. Thyroid dysfunctions in the form of overt or subclinical hypothyroidism are prevalent among patients with NAFLD/NASH. Hypothyroidism appears to be an independent risk factor for NAFLD/NASH in some studies; however, other newly published studies failed to find such an association. The results of the studies on the role of thyroid abnormalities in NAFLD/NASH are inconsistent, and further research is recommended to determine the relationship between hypothyroidism and NAFLD/NASH and the underlying mechanisms. (C) 2014 Baishideng Publishing Group Inc. All rights reserved.
C1 [Eshraghian, Ahad] Shiraz Univ Med Sci, Dept Internal Med, Namazi Hosp, Shiraz, Iran.
   [Jahromi, Alireza Hamidian] Louisiana State Univ, Hlth Sci Ctr, Dept Surg, Shreveport, LA 70803 USA.
C3 Shiraz University of Medical Science; Louisiana State University System;
   Louisiana State University Health Sciences Center at Shreveport
RP Eshraghian, A (corresponding author), Shiraz Univ Med Sci, Dept Internal Med, Namazi Hosp, POB 71345-1744, Shiraz, Iran.
EM eshraghiana@yahoo.com
RI Hamidian Jahromi, Alireza/F-3387-2010; Eshraghian, Ahad/U-3853-2019
OI Hamidian Jahromi, Alireza/0000-0002-7585-847X
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NR 69
TC 100
Z9 110
U1 1
U2 19
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 7041 Koll Center Parkway, Suite 160, PLEASANTON, CA, UNITED STATES
SN 1007-9327
EI 2219-2840
J9 WORLD J GASTROENTERO
JI World J. Gastroenterol.
PD JUL 7
PY 2014
VL 20
IS 25
BP 8102
EP 8109
DI 10.3748/wjg.v20.i25.8102
PG 8
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA AK6EM
UT WOS:000338520900014
PM 25009382
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Wu, CH
   Chen, SC
   Ou, TT
   Chyau, CC
   Chang, YC
   Wang, CJ
AF Wu, Cheng-Hsun
   Chen, Shu-Chun
   Ou, Ting-Tsz
   Chyau, Charng-Cherng
   Chang, Yun-Ching
   Wang, Chau-Jong
TI Mulberry leaf polyphenol extracts reduced hepatic lipid accumulation
   involving regulation of adenosine monophosphate activated protein kinase
   and lipogenic enzymes
SO JOURNAL OF FUNCTIONAL FOODS
LA English
DT Article
DE Mulberry leaf polyphenol extracts; Fatty acid synthetase; Acetyl-CoA
   carboxylase; HMG-CoA reductase; AMP-actived protein kinase;
   Non-alcoholic fatty liver disease
ID ELEMENT-BINDING PROTEINS; FATTY LIVER-DISEASE; OXIDATIVE STRESS;
   ADIPOSE-TISSUE; ACID; CHOLESTEROL; INFLAMMATION; DIET; METABOLISM;
   EXPRESSION
AB Fat accumulation in the liver increases the risk of developing progressive liver injury. It can induce all the symptoms of metabolic syndrome, which is associated with many additional health problems, including increased risk of obesity, hypertension, insulin resistance, and non-alcoholic fatty liver disease (NAFLD). Therefore, prevention and treatment of fat accumulation in the liver are relevant to health promotion. Mulberry leaf polyphenol extracts (MLPE) have been known to modulate serum fasting glucose, lipid and antiatherosclerosis. However, the effect of MLPE on regulating hepatic lipid metabolism is unclear. This study evaluated the effects and mechanisms of MLPE in reducing hepatic lipid accumulation in cell culture. We found MLPE could regulate hepatic lipid accumulation. Further, numerous lipogenic enzymes, such as FAS (fatty acid synthetase), ACC (acetyl-CoA carboxylase), HMGCR (HMG-CoA reductase) and associated-lipogenic transcriptional factors (SREBP1 and SREBP2) were suppressed by MLPE. Our results show MLPE is able to reduce hepatic lipid accumulation through activation of the AMPK (AMP-activating protein kinase) signaling pathway. It may have potential therapeutic implications for human NFALD. (C) 2013 Elsevier Ltd. All rights reserved.
C1 [Wu, Cheng-Hsun] China Med Univ, Dept Anat, Taichung 404, Taiwan.
   [Wu, Cheng-Hsun] China Med Univ, Dept Biochem, Taichung 404, Taiwan.
   [Wu, Cheng-Hsun] China Med Univ Hosp, Dept Med Res, Taichung 404, Taiwan.
   [Chen, Shu-Chun; Ou, Ting-Tsz; Chang, Yun-Ching; Wang, Chau-Jong] Chung Shan Med Univ, Inst Biochem & Biotechnol, Taichung, Taiwan.
   [Chang, Yun-Ching; Wang, Chau-Jong] Chung Shan Med Univ, Dept Med Res, Taichung 402, Taiwan.
   [Chyau, Charng-Cherng] Hung Kuang Univ, Coll Med & Nursing, Inst Biotechnol, Taichung, Taiwan.
C3 China Medical University Taiwan; China Medical University Taiwan; China
   Medical University Taiwan; China Medical University Hospital - Taiwan;
   Chung Shan Medical University; Chung Shan Medical University; Hungkuang
   University
RP Chang, YC (corresponding author), 110,Sec 1,Jianguo N Rd, Taichung 402, Taiwan.
EM changyc@csmu.edu.tw; wcj@csmu.edu.tw
RI chen, changhan/K-6713-2018; 陈, 文杰·/HHN-5495-2022; Chueh,
   Chu-Chen/AAA-5063-2019
FU National Science Council, Taiwan [NSC99-2632-13040-MY3]
FX This study was supported by National Science Council
   (NSC99-2632-13040-MY3), Taiwan.
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NR 44
TC 52
Z9 58
U1 1
U2 33
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1756-4646
J9 J FUNCT FOODS
JI J. Funct. Food.
PD OCT
PY 2013
VL 5
IS 4
BP 1620
EP 1632
DI 10.1016/j.jff.2013.07.004
PG 13
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA AN6VS
UT WOS:000340737100012
DA 2025-06-11
ER

PT J
AU Singh, CK
   Kumar, A
   LaVoie, HA
   DiPette, DJ
   Singh, US
AF Singh, Chandra K.
   Kumar, Ambrish
   LaVoie, Holly A.
   DiPette, Donald J.
   Singh, Ugra S.
TI Diabetic complications in pregnancy: is resveratrol a solution?
SO EXPERIMENTAL BIOLOGY AND MEDICINE
LA English
DT Review
DE diabetic pregnancy; neural tube defects; resveratrol; hyperglycemia
ID ACTIVATED PROTEIN-KINASE; NEURAL-TUBE DEFECTS; INDUCED NEURONAL
   DIFFERENTIATION; IMPROVES ENDOTHELIAL FUNCTION; FOLIC-ACID
   SUPPLEMENTATION; SMALL-MOLECULE ACTIVATORS; CENTRAL-NERVOUS-SYSTEM;
   RETINOIC ACID; CONGENITAL-MALFORMATIONS; OXIDATIVE STRESS
AB Diabetes is a metabolic disorder that, during pregnancy, may affect fetal development. Fetal outcome depends on the type of diabetes present, the concentration of blood glucose and the extent of fetal exposure to elevated or frequently fluctuating glucose concentrations. The result of some diabetic pregnancies will be embryonic developmental abnormalities, a condition referred to as diabetic embryopathy. Tight glycemic control in type 1 diabetes during pregnancy using insulin therapy together with folic acid supplementation are partially able to prevent diabetic embryopathy; however, the protection is not complete and additional interventions are needed. Resveratrol, a polyphenol found largely in the skins of red grapes, is known to have antidiabetic action and is in clinical trials for the treatment of diabetes, insulin resistance, obesity and metabolic syndrome. Studies of resveratrol in a rodent model of diabetic embryopathy reveal that it significantly improves the embryonic outcome in terms of diminishing developmental abnormalities. Improvements in maternal and embryonic outcomes observed in rodent models may arise from resveratrol's antioxidative potential, antidiabetic action and antidyslipidemic nature. Whether resveratrol will have similar actions in human diabetic pregnancy is unknown. Here, we review the potential therapeutic use of resveratrol in diabetes and diabetic pregnancy.
C1 [Singh, Chandra K.; Kumar, Ambrish; Singh, Ugra S.] Sch Med, Dept Pathol Microbiol & Immunol, Columbia, SC 29209 USA.
   [Singh, Chandra K.] Univ Wisconsin, Dept Dermatol, Madison, WI 53706 USA.
   [LaVoie, Holly A.; DiPette, Donald J.] Univ S Carolina, Sch Med, Dept Cell Biol & Anat, Columbia, SC 29209 USA.
C3 University of Wisconsin System; University of Wisconsin Madison;
   University of South Carolina System; University of South Carolina
   Columbia
RP Singh, US (corresponding author), Sch Med, Dept Pathol Microbiol & Immunol, 6311 Garners Ferry Rd, Columbia, SC 29209 USA.
EM Ugra.Singh@uscmed.sc.edu
RI LaVoie, Holly/L-6057-2017; Singh, Chandra/AAO-6773-2020; Kumar,
   Ambrish/B-7347-2014
OI Kumar, Ambrish/0000-0002-7576-561X
FU NIH [R21AA016121]; Health Sciences Distinguished Professorship
FX This research was supported in part by NIH R21AA016121 (US) and Health
   Sciences Distinguished Professorship (DJD).
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NR 112
TC 35
Z9 37
U1 0
U2 28
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1535-3702
EI 1535-3699
J9 EXP BIOL MED
JI Exp. Biol. Med.
PD MAY
PY 2013
VL 238
IS 5
BP 482
EP 490
DI 10.1177/1535370212473704
PG 9
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 182QG
UT WOS:000321758200004
PM 23436883
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Inoue, T
   Node, K
AF Inoue, Teruo
   Node, Koichi
TI Statin therapy for vascular failure
SO CARDIOVASCULAR DRUGS AND THERAPY
LA English
DT Review
DE statin; pleiotropic effect; coronary artery disease; atherosclerosis;
   vascular failure; vascular endothelial function; vascular smooth muscle
   function; inflammation; oxidative stress
ID CORONARY-ARTERY-DISEASE; COA REDUCTASE INHIBITORS; C-REACTIVE PROTEIN;
   LOW-DENSITY-LIPOPROTEIN; INTIMA-MEDIA THICKNESS; ENDOTHELIAL PROGENITOR
   CELLS; RANDOMIZED CONTROLLED-TRIAL; PLASMA-CHOLESTEROL LEVELS;
   ISCHEMIC-HEART-DISEASE; SIMVASTATIN PRESERVES
AB There is increasing evidence that statins reduce cardiovascular events such as coronary artery disease or stroke in hypercholesterolemic patients in both primary and secondary prevention. The striking benefit achieved with statin treatments in patients with a wide range of cholesterol levels cannot be attributed to their cholesterol lowering effect alone. Substantial data has recently accumulated showing that statins exert various effects on multiple targets, namely pleiotropic effects, especially targeting the concept of 'vascular failure', including the improvement of vascular endothelial function, inhibition of vascular smooth muscle cell proliferation and migration, anti-inflammatory actions, anti-oxidative effects or stabilization of vulnerable plaques. These effects have potential in the treatments of coronary artery disease in various settings, such as prevention of its onset as well as its progression, or plaque rupture. Statin therapy should be more extensively applied even in normolipidemic patients if there are additional risk factors such as hypertension, diabetes mellitus, or others. Furthermore, statins may be used to intervene in earlier stage risk conditions such as postprandial hyperlipidemia or hyperglycemia, insulin resistant state, masked hypertension, or metabolic syndrome to further reduce mortality or morbidity of coronary artery disease and heart failure.
C1 Saga Univ, Fac Med, Dept Cardiovasc & Renal Med, Saga 8498501, Japan.
C3 Saga University
RP Inoue, T (corresponding author), Saga Univ, Fac Med, Dept Cardiovasc & Renal Med, 5-1-1 Nabeshima, Saga 8498501, Japan.
EM inouete@med.saga-u.ac.jp
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NR 128
TC 26
Z9 29
U1 0
U2 1
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0920-3206
EI 1573-7241
J9 CARDIOVASC DRUG THER
JI Cardiovasc. Drugs Ther.
PD AUG
PY 2007
VL 21
IS 4
BP 281
EP 295
DI 10.1007/s10557-007-6038-y
PG 15
WC Cardiac & Cardiovascular Systems; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Pharmacology & Pharmacy
GA 209QJ
UT WOS:000249402800008
PM 17682928
DA 2025-06-11
ER

PT J
AU Lv, XY
   Ding, PP
   Li, LY
   Li, L
   Zhou, DL
   Wang, XC
   Chen, JF
   Zhang, W
   Wang, Q
   Liao, T
   Wen, WY
   Zhou, DW
   Ji, QH
   He, XH
   Lei, QY
   Hu, WG
AF Lv, Xinyue
   Ding, Peipei
   Li, Luying
   Li, Ling
   Zhou, Danlei
   Wang, Xiaochao
   Chen, Jianfeng
   Zhang, Wei
   Wang, Qi
   Liao, Tian
   Wen, Wenyu
   Zhou, Dawang
   Ji, Qing-Hai
   He, Xianghuo
   Lei, Qun-Ying
   Hu, Weiguo
TI Increased α-HB links colorectal cancer and diabetes by potentiating
   NF-κB signaling
SO MOLECULAR METABOLISM
LA English
DT Article
DE a-Hydroxybutyrate; Type 2 diabetes; Colorectal cancer; Lactate
   dehydrogenase A; NF-kB
ID NUCLEAR EXPORT SIGNAL; KAPPA-B-ALPHA; METABOLIC SYNDROME; OXIDATIVE
   STRESS; METFORMIN; INFLAMMATION; BIOMARKERS; CELLS; DISORDERS; IMMUNITY
AB Sufficient evidence has linked many different types of cancers and T2D through shared risk factors; however, the underlying mechanisms are not fully understood. a-Hydroxybutyrate (a-HB), a byproduct metabolite increased in diabetes and cancer, including colorectal cancer (CRC), triggers lactate dehydrogenase A (LDHA) nuclear translocation. Nuclear LDHA markedly extends NF-kB nuclear retention by interacting with phosphorylated p65, leading to an increase in TNF-a production, impaired insulin secretion and the exacerbation of azoxymethane (AOM)/dextran sodium sulfate (DSS)-induced CRC and high-fat diet (HFD)-induced type 2 diabetes. Furthermore, metformin interrupted this process by inhibiting the transcription of FOXM1 and c-MYC, the resultant downregulation of LDHA expression and a-HB-induced LDHA nuclear translocation. Thus, the results reveal the elevated a-HB level could be a novel shared risk factor of linking CRC, diabetes and the use of metformin treatment, as well as highlight the importance of preventing NF-kB activation for protecting against cancer and diabetes. m 2023 The Author(s). Published by Elsevier GmbH. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
C1 [Lv, Xinyue; Ding, Peipei; Li, Luying; Li, Ling; Zhou, Danlei; Wang, Xiaochao; Chen, Jianfeng; Zhang, Wei; Wang, Qi; Wen, Wenyu; He, Xianghuo; Lei, Qun-Ying; Hu, Weiguo] Fudan Univ, Shanghai Canc Ctr, Shanghai 200032, Peoples R China.
   [Lv, Xinyue; Ding, Peipei; Li, Luying; Li, Ling; Zhou, Danlei; Wang, Xiaochao; Chen, Jianfeng; Zhang, Wei; Wang, Qi; Wen, Wenyu; He, Xianghuo; Lei, Qun-Ying; Hu, Weiguo] Fudan Univ, Inst Biomed Sci, Shanghai Med Coll, Shanghai 200032, Peoples R China.
   [Liao, Tian; Ji, Qing-Hai] Xiamen Univ, Innovat Ctr Cell Signaling Network, Sch Life Sci, State Key Lab Cellular Stress Biol, Xiamen 361102, Fujian, Peoples R China.
   [Zhou, Dawang] Fudan Univ, Shanghai Canc Ctr, Key Lab Breast Canc Shanghai, Shanghai 200032, Peoples R China.
C3 Fudan University; Fudan University; Xiamen University; Fudan University
RP Hu, WG (corresponding author), Fudan Univ, Shanghai Canc Ctr, Shanghai 200032, Peoples R China.; Hu, WG (corresponding author), Fudan Univ, Inst Biomed Sci, Shanghai Med Coll, Shanghai 200032, Peoples R China.
EM weiguohu@fudan.edu.cn
RI Lei, Qun-Ying/J-1390-2017; Wen, Wenyu/ABR-2102-2022; Zhang,
   Jiajia/ABB-6049-2020; Hu, Weiguo/AAP-2239-2021; Lyu,
   Xinyue/HZJ-9283-2023; Chen, Jianfeng/HTN-8931-2023; He,
   Xianghuo/I-1497-2014
OI Hu, Weiguo/0000-0002-7397-6800; He, Xianghuo/0000-0001-8872-668X; Chen,
   Jianfeng/0000-0002-4182-145X
FU National Natural Science Foundation of China [81790254, 91629301,
   81872354, 82121004]; Major State Basic Research Development Program of
   China [2013CB910802]
FX This work was supported by grants to W.H. from the National Natural
   Science Foundation of China (81790254, 91629301, 81872354 and 82121004)
   and the Major State Basic Research Development Program of China
   (2013CB910802) .
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NR 71
TC 1
Z9 1
U1 0
U2 9
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2212-8778
J9 MOL METAB
JI Mol. Metab.
PD SEP
PY 2023
VL 75
AR 101766
DI 10.1016/j.molmet.2023.101766
EA JUL 2023
PG 16
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA O8TW6
UT WOS:001046498200001
PM 37406987
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Abdalqadir, N
   Adeli, K
AF Abdalqadir, Nyan
   Adeli, Khosrow
TI GLP-1 and GLP-2 Orchestrate Intestine Integrity, Gut Microbiota, and
   Immune System Crosstalk
SO MICROORGANISMS
LA English
DT Review
DE glucagon-like peptide 1 (GLP-1); glucagon-like peptide 2 (GLP-2); gut
   microbiota; intestinal barrier integrity; inflammation; gut immunity;
   metabolic syndrome
ID GLUCAGON-LIKE PEPTIDE-1; CHAIN FATTY-ACIDS; PROTEIN-COUPLED RECEPTOR;
   GERM-FREE MICE; CHYLOMICRON PRODUCTION; INSULIN-SECRETION; OXIDATIVE
   STRESS; FOOD-INTAKE; L CELLS; LIPOPROTEIN PRODUCTION
AB The intestine represents the body's largest interface between internal organs and external environments except for its nutrient and fluid absorption functions. It has the ability to sense numerous endogenous and exogenous signals from both apical and basolateral surfaces and respond through endocrine and neuronal signaling to maintain metabolic homeostasis and energy expenditure. The intestine also harbours the largest population of microbes that interact with the host to maintain human health and diseases. Furthermore, the gut is known as the largest endocrine gland, secreting over 100 peptides and other molecules that act as signaling molecules to regulate human nutrition and physiology. Among these gut-derived hormones, glucagon-like peptide 1 (GLP-1) and -2 have received the most attention due to their critical role in intestinal function and food absorption as well as their application as key drug targets. In this review, we highlight the current state of the literature that has brought into light the importance of GLP-1 and GLP-2 in orchestrating intestine-microbiota-immune system crosstalk to maintain intestinal barrier integrity, inflammation, and metabolic homeostasis.
C1 [Abdalqadir, Nyan; Adeli, Khosrow] Hosp Sick Children, Res Inst, Mol Med, Toronto, ON M5G 1H3, Canada.
   [Abdalqadir, Nyan; Adeli, Khosrow] Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON M5S 1A8, Canada.
   [Abdalqadir, Nyan] Univ Sulaimani, Coll Sci, Dept Biol, Sulaymaniyah 46001, Iraq.
   [Adeli, Khosrow] Univ Toronto, Dept Biochem, Toronto, ON M5S 1A8, Canada.
   [Adeli, Khosrow] Univ Toronto, Dept Physiol, Toronto, ON M5S 1A8, Canada.
C3 University of Toronto; Hospital for Sick Children (SickKids); University
   of Toronto; University of Sulimanyah; University of Toronto; University
   of Toronto
RP Adeli, K (corresponding author), Hosp Sick Children, Res Inst, Mol Med, Toronto, ON M5G 1H3, Canada.; Adeli, K (corresponding author), Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON M5S 1A8, Canada.; Adeli, K (corresponding author), Univ Toronto, Dept Biochem, Toronto, ON M5S 1A8, Canada.; Adeli, K (corresponding author), Univ Toronto, Dept Physiol, Toronto, ON M5S 1A8, Canada.
EM khosrow.adeli@sickkids.ca
OI Adeli, Khosrow/0000-0002-5839-5709
FU Canadian Institute of Health Research (CIHR) [FDN-148396]
FX This work was supported by a Foundation Grant to K.A. by the Canadian
   Institute of Health Research (CIHR), FDN-148396.
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NR 210
TC 50
Z9 52
U1 1
U2 33
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-2607
J9 MICROORGANISMS
JI Microorganisms
PD OCT
PY 2022
VL 10
IS 10
AR 2061
DI 10.3390/microorganisms10102061
PG 20
WC Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Microbiology
GA 5P2JK
UT WOS:000872983100001
PM 36296337
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Shi, XY
   Zheng, YX
   Cui, HW
   Zhang, YX
   Jiang, MH
AF Shi, Xiaoyi
   Zheng, Yuxin
   Cui, Haiwen
   Zhang, Yuxi
   Jiang, Menghui
TI Exposure to outdoor and indoor air pollution and risk of overweight and
   obesity across different life periods: A review
SO ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
LA English
DT Review
DE Air pollution; Obesity; Epidemiology; Mechanism; Prevention
ID CHILDHOOD OBESITY; PARTICULATE MATTER; ENVIRONMENTAL EXPOSURES;
   RESPIRATORY-DISEASES; METABOLIC SYNDROME; GUT MICROBIOTA; TERM EXPOSURE;
   GREEN SPACE; CHILDREN; LEPTIN
AB Due to the highly evolved industrialization and modernization, air quality has deteriorated in most countries. As reported by the World Health Organization (WHO), air pollution is now considered as one of the major threats to global health and a principal risk factor for noncommunicable diseases. Meanwhile, the increasing worldwide prevalence of overweight and obesity is attracting more public attentions. Recently, accumulating epidemio-logical studies have provided evidence that overweight and obesity may be partially attributable to environ-mental exposure to air pollution. This review summarizes the epidemiological evidence for the correlation between exposure to various outdoor and indoor air pollutants (mainly particulate matter (PM), nitrogen oxides (NOx), ozone (O3), and polycyclic aromatic hydrocarbons (PAHs)) and overweight and obesity outcomes in recent years. Moreover, it discusses the multiple effects of air pollution during exposure periods throughout life and sex differences in populations. This review also describes the potential mechanism underlying the increased risk of obesity caused by air pollution, including inflammation, oxidative stress, metabolic imbalance, intestinal flora disorders and epigenetic modifications. Finally, this review proposes macro-and micro-measures to prevent the negative effects of air pollution exposure on the obesity prevalence.
C1 [Shi, Xiaoyi; Zheng, Yuxin; Cui, Haiwen; Zhang, Yuxi; Jiang, Menghui] Qingdao Univ, Sch Publ Hlth, 308 Ningxia Rd, Qingdao 266071, Peoples R China.
C3 Qingdao University
RP Jiang, MH (corresponding author), Qingdao Univ, Sch Publ Hlth, 308 Ningxia Rd, Qingdao 266071, Peoples R China.
EM jiangmenghui@qdu.edu.cn
RI 梦会, 蒋/KTI-0885-2024; Zhang, Yuxi/ABC-8172-2020
FU Program of the National Natural Science Foundation of China [82073597]
FX This study was supported by grants from the Program of the National
   Natural Science Foundation of China (82073597) .
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NR 160
TC 48
Z9 52
U1 4
U2 55
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0147-6513
EI 1090-2414
J9 ECOTOX ENVIRON SAFE
JI Ecotox. Environ. Safe.
PD SEP 1
PY 2022
VL 242
AR 113893
DI 10.1016/j.ecoenv.2022.113893
EA JUL 2022
PG 14
WC Environmental Sciences; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Toxicology
GA 5C0ZF
UT WOS:000863995600008
PM 35917711
OA gold
DA 2025-06-11
ER

PT J
AU Pavel, P
   Blunder, S
   Moosbrugger-Martinz, V
   Elias, PM
   Dubrac, S
AF Pavel, Petra
   Blunder, Stefan
   Moosbrugger-Martinz, Verena
   Elias, Peter M.
   Dubrac, Sandrine
TI Atopic Dermatitis: The Fate of the Fat
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE atopic dermatitis; lipids; epidermal barrier; ceramides; eicosanoids;
   filaggrin; eczema
ID STAPHYLOCOCCUS-AUREUS COLONIZATION; SKIN BARRIER FUNCTION;
   STRATUM-CORNEUM LIPIDS; LANGERHANS CELLS; METABOLIC SYNDROME; ENHANCED
   EXPRESSION; LEUKOTRIENE B-4; DENDRITIC CELLS; IN-VITRO; T-CELLS
AB Atopic dermatitis (AD) is a chronic and relapsing inflammatory skin disease in which dry and itchy skin may develop into skin lesions. AD has a strong genetic component, as children from parents with AD have a two-fold increased chance of developing the disease. Genetic risk loci and epigenetic modifications reported in AD mainly locate to genes involved in the immune response and epidermal barrier function. However, AD pathogenesis cannot be fully explained by (epi)genetic factors since environmental triggers such as stress, pollution, microbiota, climate, and allergens also play a crucial role. Alterations of the epidermal barrier in AD, observed at all stages of the disease and which precede the development of overt skin inflammation, manifest as: dry skin; epidermal ultrastructural abnormalities, notably anomalies of the lamellar body cargo system; and abnormal epidermal lipid composition, including shorter fatty acid moieties in several lipid classes, such as ceramides and free fatty acids. Thus, a compelling question is whether AD is primarily a lipid disorder evolving into a chronic inflammatory disease due to genetic susceptibility loci in immunogenic genes. In this review, we focus on lipid abnormalities observed in the epidermis and blood of AD patients and evaluate their primary role in eliciting an inflammatory response.
C1 [Pavel, Petra; Blunder, Stefan; Moosbrugger-Martinz, Verena; Dubrac, Sandrine] Med Univ Innsbruck, Dept Dermatol Venereol & Allergol, A-6020 Innsbruck, Austria.
   [Elias, Peter M.] Univ Calif San Francisco, Dept Dermatol, San Francisco, CA 94115 USA.
C3 Medical University of Innsbruck; University of California System;
   University of California San Francisco
RP Dubrac, S (corresponding author), Med Univ Innsbruck, Dept Dermatol Venereol & Allergol, A-6020 Innsbruck, Austria.
EM petra.pavel2@gmail.com; stefan.blunder@i-med.ac.at;
   verena.martinz@i-med.ac.at; peter.elias@ucsf.edu;
   sandrine.dubrac@i-med.ac.at
OI Elias, Peter/0000-0001-7989-4032; Dubrac, Sandrine/0000-0002-2936-8488
FU Austrian Science Fund [FWF 31662]
FX FundingDeclaration of all sources of funding: This work was supported by
   grants from the Austrian Science Fund and the Tyrol Research Fund (FWF
   31662) to SD.
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NR 181
TC 19
Z9 19
U1 0
U2 11
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD FEB
PY 2022
VL 23
IS 4
AR 2121
DI 10.3390/ijms23042121
PG 20
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA ZR0PE
UT WOS:000767494900001
PM 35216234
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Enes, BN
   Moreira, LPD
   Silva, BP
   Grancieri, M
   Lúcio, HG
   Venâncio, VP
   Mertens-Talcott, SU
   Rosa, COB
   Martino, HSD
AF Enes, Barbara N.
   Moreira, Luiza P. D.
   Silva, Barbara P.
   Grancieri, Mariana
   Lucio, Haira G.
   Venancio, Vinicius P.
   Mertens-Talcott, Susanne U.
   Rosa, Carla O. B.
   Martino, Hercia S. D.
TI Chia seed (Salvia hispanica L.) effects and their molecular
   mechanisms on unbalanced diet experimental studies: A systematic review
SO JOURNAL OF FOOD SCIENCE
LA English
DT Review
DE alpha linolenic acid; chia seed; dyslipidemia; glucose tolerance; Salvia
   hispanica L
ID ALPHA-LINOLENIC ACID; ADIPOSE-TISSUE DYSFUNCTION; DISEASE RISK-FACTORS;
   PHENOLIC-COMPOUNDS; OXIDATIVE STRESS; ANTIOXIDANT ACTIVITY; METABOLIC
   SYNDROME; HIGH-CARBOHYDRATE; FATTY-ACIDS; WEIGHT-LOSS
AB The aim of this review was to compile evidence and understand chia seed effects on unbalanced diet animal studies and the molecular mechanisms on metabolic biomarker modulation. A systematic review was conducted in electronic databases, following PRISMA recommendations. Risk of bias and quality was assessed using SYRCLE toll and ARRIVE guidelines. Seventeen articles were included. Throughout the studies, chia's main effects are associated with AMPK modulation: improvement of glucose and insulin tolerance, lipogenesis, antioxidant activity, and inflammation. Details about randomization and allocation concealment were insufficient, as well as information about blind protocols. Sample size, chia dose, and number of animals evaluated for each parameter were found to be lacking information among the studies. Based on experimental study data, chia has bioactive potential, and its daily consumption may reduce the risk of chronic disease development, mainly due to the antioxidant, anti-inflammatory, hypoglycemic, and hypolipidemic effects of the seed. Practical Application The consumption of chia seeds may improve lipid profile, insulin and glucose tolerance, and reduce risk of cardiovascular disease. Whole seed or its oil presents positive effect, but the effects of chia oil can act faster than the seed.
C1 [Enes, Barbara N.; Moreira, Luiza P. D.; Silva, Barbara P.; Grancieri, Mariana; Lucio, Haira G.; Rosa, Carla O. B.; Martino, Hercia S. D.] Univ Fed Vicosa, Dept Nutr & Hlth, BR-36570900 Vicosa, MG, Brazil.
   [Venancio, Vinicius P.; Mertens-Talcott, Susanne U.] Texas A&M Univ, Dept Nutr & Food Sci, College Stn, TX 77843 USA.
C3 Universidade Federal de Vicosa; Texas A&M University System; Texas A&M
   University College Station
RP Martino, HSD (corresponding author), Univ Fed Vicosa, Dept Nutr & Hlth, BR-36570900 Vicosa, MG, Brazil.
EM hercia72@gmail.com
RI Silva, Barbara/NKO-7601-2025; Grancieri, Mariana/D-1225-2018; Venancio,
   Vinicius/H-8188-2012
OI Guedes Lucio, Haira/0000-0001-6121-5919; Enes,
   Barbara/0000-0002-1358-7723; Mertens-Talcott,
   Susanne/0000-0003-2828-4044; Venancio, Vinicius/0000-0003-3239-6380;
   Rosa, Carla/0000-0003-1463-3055; da Silva, Barbara
   Pereira/0000-0003-1096-456X; de Paula Dias Moreira,
   Luiza/0000-0003-3981-2498
FU Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES);
   Fundacao de Amparo a Pesquisa do Estado de Minas Gerais (FAPEMIG);
   Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
FX We thank Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior
   (CAPES), Fundacao de Amparo a Pesquisa do Estado de Minas Gerais
   (FAPEMIG), and Conselho Nacional de Desenvolvimento Cientifico e
   Tecnologico (CNPq) for the financial support.
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NR 70
TC 31
Z9 32
U1 3
U2 22
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-1147
EI 1750-3841
J9 J FOOD SCI
JI J. Food Sci.
PD FEB
PY 2020
VL 85
IS 2
BP 226
EP 239
DI 10.1111/1750-3841.15003
EA JAN 2020
PG 14
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA LP0DV
UT WOS:000508784500001
PM 31972052
OA Bronze
DA 2025-06-11
ER

PT J
AU Wisnieski, L
   Norby, B
   Pierce, SJ
   Becker, T
   Sordillo, LM
AF Wisnieski, Lauren
   Norby, Bo
   Pierce, Steven J.
   Becker, Tyler
   Sordillo, Lorraine M.
TI Prospects for predictive modeling of transition cow diseases
SO ANIMAL HEALTH RESEARCH REVIEWS
LA English
DT Review
DE Disease prediction; predictive modeling; statistical methods; transition
   dairy cattle
ID BETA-HYDROXYBUTYRATE CONCENTRATIONS; LOGISTIC-REGRESSION ANALYSIS;
   CONFIRMATORY FACTOR-ANALYSIS; NONESTERIFIED FATTY-ACIDS; BODY CONDITION
   SCORE; DAIRY-CATTLE; METABOLIC SYNDROME; REPRODUCTIVE-PERFORMANCE;
   OXIDATIVE STRESS; RISK-FACTORS
AB Transition cow diseases can negatively impact animal welfare and reduce dairy herd profitability. Transition cow disease incidence has remained relatively stable over time despite monitoring and management efforts aimed to reduce the risk of developing diseases. Dairy cattle disease risk is monitored by assessing multiple factors, including certain biomarker test results, health records, feed intake, body condition score, and milk production. However, these factors, which are used to make herd management decisions, are often reviewed separately without considering the correlation between them. In addition, the biomarkers that are currently used for monitoring may not be representative of the complex physiological changes that occur during the transition period. Predictive modeling, which uses data to predict future or current outcomes, is a method hat can be used to combine the most predictive variables and their interactions efficiently. The use of an effective predictive model with relevant predictors for transition cow diseases will result in better targeted interventions, and therefore lower disease incidence. ThiS review will discuss predictive modeling methods and candidate variables in the context of transition cow diseases. The next step is to investigate navel biomarkers and statistical methods that are best suited for the prediction of transition cow diseases.
C1 [Wisnieski, Lauren] Kansas State Univ, Ctr Res Outcomes & Epidemiol, 310 Coles Hall, Manhattan, KS 66506 USA.
   [Norby, Bo; Sordillo, Lorraine M.] Michigan State Univ, Dept Large Anim Clin Sci, 736 Wilson Rd,Room A-201, E Lansing, MI 48824 USA.
   [Pierce, Steven J.] Michigan State Univ, Ctr Stat Training & Consulting, 293 Farm Lane,Room 100A, E Lansing, MI 48824 USA.
   [Becker, Tyler] Michigan State Univ, Dept Food Sci & Human Nutr, 469 Wilson Rd,Room 125, E Lansing, MI 48824 USA.
C3 Kansas State University; Michigan State University; Michigan State
   University; Michigan State University
RP Wisnieski, L (corresponding author), Kansas State Univ, Ctr Res Outcomes & Epidemiol, 310 Coles Hall, Manhattan, KS 66506 USA.
EM wisnies5@vet.k-state.edu
RI Becker, Tyler/IWE-5168-2023; Wisnieski, Lauren/AAE-7145-2022; Pierce,
   Steven/X-8821-2019
OI Becker, Tyler/0000-0003-4292-0780; Pierce, Steven/0000-0002-0679-3019;
   Sordillo, Lorraine/0000-0001-8873-3134
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NR 148
TC 9
Z9 10
U1 1
U2 13
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 1466-2523
EI 1475-2654
J9 ANIM HEALTH RES REV
JI Anim. Health Res. Rev.
PD JUN
PY 2019
VL 20
IS 1
BP 19
EP 30
DI 10.1017/S1466252319000112
PG 12
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Veterinary Sciences
GA KD4WK
UT WOS:000507866400002
PM 31895019
DA 2025-06-11
ER

PT J
AU Akoumianakis, I
   Antoniades, C
AF Akoumianakis, Ioannis
   Antoniades, Charalambos
TI The interplay between adipose tissue and the cardiovascular system: is
   fat always bad?
SO CARDIOVASCULAR RESEARCH
LA English
DT Review
DE Obesity; Perivascular fat; Epicardial fat; Vascular redox state;
   Myocardial redox state
ID NITRIC-OXIDE SYNTHASE; OXIDATIVE STRESS; ENDOTHELIAL DYSFUNCTION;
   HYDROGEN-SULFIDE; NATRIURETIC-PEPTIDE; PLASMA ADIPONECTIN; SIGNALING
   PATHWAYS; INSULIN-RESISTANCE; METABOLIC SYNDROME; PERIVASCULAR FAT
AB Obesity is a risk factor for cardiovascular disease (CVD). However, clinical research has revealed a paradoxically protective role for obesity in patients with chronic diseases including CVD, suggesting that the biological 'quality' of adipose tissue (AT) may be more important than overall AT mass or body weight. Importantly, AT is recognised as a dynamic organ secreting a wide range of biologically active adipokines, microRNAs, gaseous messengers, and other metabolites that affect the cardiovascular system in both endocrine and paracrine ways. Despite being able to mediate normal cardiovascular function under physiological conditions, AT undergoes a phenotypic shift characterised by acquisition of pro-oxidant and pro-inflammatory properties in cases of CVD. Crucially, recent evidence suggests that AT depots such as perivascular AT and epicardial AT are able to modify their phenotype in response to local signals of vascular and myocardial origin, respectively. Utilisation of this unique property of certain AT depots to dynamically track cardiovascular biology may reveal novel diagnostic and prognostic tools against CVD. Better understanding of the mechanisms controlling the 'quality' of AT secretome, as well as the communication links between AT and the cardiovascular system, is required for the efficient management of CVD.
C1 [Akoumianakis, Ioannis; Antoniades, Charalambos] Univ Oxford, Radcliffe Dept Med, Div Cardiovasc Med, Oxford, England.
C3 University of Oxford
RP Antoniades, C (corresponding author), Univ Oxford, Div Cardiovasc Med, John Radcliffe Hosp, CVM L6 West Wing,Headley Way, Oxford OX3 9DU, England.
EM antoniad@well.ox.ac.uk
RI Akoumianakis, Ioannis/ACD-9816-2022
OI Akoumianakis, Ioannis/0000-0002-4674-0210; Antoniades,
   Charalambos/0000-0002-6983-5423
FU British Heart Foundation [FS/16/15/32047, PG/13/56/30383]; National
   Institute for Health Research Oxford Biomedical Research Centre;
   European commission (ITN network RADOX); NovoNordisk Foundation
   [NNF15CC0018486]; Alexandros S. Onassis Public Benefit Foundation
FX C.A. acknowledges support by the British Heart Foundation
   (FS/16/15/32047 and PG/13/56/30383), the National Institute for Health
   Research Oxford Biomedical Research Centre, the European commission (ITN
   network RADOX), and the NovoNordisk Foundation (NNF15CC0018486). I. A.
   acknowledges support by the Alexandros S. Onassis Public Benefit
   Foundation.
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NR 122
TC 109
Z9 113
U1 0
U2 10
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0008-6363
EI 1755-3245
J9 CARDIOVASC RES
JI Cardiovasc. Res.
PD JUL 15
PY 2017
VL 113
IS 9
BP 999
EP 1008
DI 10.1093/cvr/cvx111
PG 10
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA FA5RG
UT WOS:000405500600002
PM 28582523
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Brookheart, RT
   Swearingen, AR
   Collins, CA
   Cline, LM
   Duncan, JG
AF Brookheart, Rita T.
   Swearingen, Alison R.
   Collins, Christina A.
   Cline, Laura M.
   Duncan, Jennifer G.
TI High-sucrose-induced maternal obesity disrupts ovarian function and
   decreases fertility in Drosophila melanogaster
SO BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
LA English
DT Article
DE Obesity; Drosophila; Ovary; Mitochondria; Pregnancy; Nutritional
   programming
ID DIET-INDUCED OBESITY; MITOCHONDRIAL DYSFUNCTION; INSULIN-RESISTANCE;
   METABOLIC SYNDROME; OXIDATIVE STRESS; STEM-CELLS; PREGNANCY; FEMALE;
   GROWTH; WOMEN
AB As the obesity epidemic worsens, the prevalence of maternal obesity is expected to rise. Both high-fat and high sucrose diets are known to promote maternal obesity and several studies have elucidated the molecular influence of high-fat feeding on female reproduction. However, to date, the molecular impact of a high-sucrose diet on maternal obesity remains to be investigated. Using our previously reported Drosophila high-sucrose maternal obesity model, we sought to determine how excess dietary sucrose impacted the ovary. High-sucrose diet (HSD) fed adult females developed systemic insulin resistance and exhibited an ovarian phenotype characterized by excess accumulation of lipids and cholesterol in the ovary, decreased ovary size, and impaired egg maturation. We also observed decreased expression of antioxidant genes and increased protein carbonylation in the ovaries of HSD females. HSD females laid fewer eggs; however, the overall survival of offspring was unchanged relative to lean control females. Ovaries of HSD females had increased mitochondrial DNA copy number and decreased expression of key mitochondrial regulators, suggestive of an ineffective compensatory response to mitochondrial dysfunction. Mitochondrial alterations were also observed in male offspring of obese females. This study demonstrates that high-sucrose-induced maternal obesity promotes insulin resistance, while disrupting ovarian metabolism and function.
C1 [Brookheart, Rita T.; Swearingen, Alison R.; Collins, Christina A.; Cline, Laura M.; Duncan, Jennifer G.] Washington Univ, Sch Med, Dept Pediat, 660 South Euclid Ave,Campus Box 8208, St Louis, MO 63110 USA.
   [Brookheart, Rita T.] Washington Univ, Sch Med, Dept Med, 660 South Euclid Ave,Campus Box 8031, St Louis, MO 63110 USA.
C3 Washington University (WUSTL); Washington University (WUSTL)
RP Duncan, JG (corresponding author), Washington Univ, Sch Med, Dept Pediat, 660 South Euclid Ave,Campus Box 8208, St Louis, MO 63110 USA.
EM duncan_j@wustl.edu
OI Pashos, Alison/0000-0001-7072-5603; Brookheart, Rita/0000-0003-3247-3243
FU American Heart Association [IRG5450013, GRNT12080056]; Washington
   University Diabetes Research Center [P30DK020579]; National Institutes
   of Health [K12HD001459]
FX This work was supported by grants from the American Heart Association
   (IRG5450013 and GRNT12080056 to J.G. Duncan), the Washington University
   Diabetes Research Center (P30DK020579 to J.G. Duncan) and the National
   Institutes of Health (K12HD001459 to R.T. Brookheart).
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NR 66
TC 24
Z9 24
U1 0
U2 21
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0925-4439
EI 1879-260X
J9 BBA-MOL BASIS DIS
JI Biochim. Biophys. Acta-Mol. Basis Dis.
PD JUN
PY 2017
VL 1863
IS 6
BP 1255
EP 1263
DI 10.1016/j.bbadis.2017.03.014
PG 9
WC Biochemistry & Molecular Biology; Biophysics; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Cell Biology
GA EZ4TE
UT WOS:000404704600010
PM 28344128
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Shi, JP
   Zhang, XY
   Wang, SY
   Wang, JJ
   Du, B
   Wang, ZG
   Liu, MY
   Jiang, WZ
   Qian, M
   Ren, H
AF Shi, Jueping
   Zhang, Xiaoyu
   Wang, Shaoying
   Wang, Jinjin
   Du, Bing
   Wang, Zhugang
   Liu, Mingyao
   Jiang, Wenzheng
   Qian, Min
   Ren, Hua
TI Gpr97 is dispensable for metabolic syndrome but is involved in
   macrophage inflammation in high-fat diet-induced obesity in mice
SO SCIENTIFIC REPORTS
LA English
DT Article
ID INSULIN-RESISTANCE; OXIDATIVE STRESS; ADIPOSE-TISSUE; EXPRESSION;
   KIDNEY; ACCUMULATION; ACTIVATION; ALPHA; CELLS; DYSFUNCTION
AB Local inflammation in tissues is one of primary causes in development of metabolic disorder in obesity. The accumulation of macrophages in some tissues can induce inflammatory reactions in obesity. Gpr97 is highly expressed in some immunocytes, but its potential role in inflammatory regulation has not been revealed clearly. In our research, we investigated Gpr97 in regulating macrophage inflammation and metabolic dysfunction in the high-fat diet (HFD)-induced obese mice. The major metabolic phenotyping were not different after Gpr97 knockout in HFD-fed mice. Similar pathological alterations in adipose tissue, liver, and kidney were observed in Gpr97(-/-) HFD mice compared with WT-HFD mice. In white adipose tissue, loss of Gpr97 reduced the ratio of M1-macrophages and increased the M2-macrophage ratio, which was opposite to that seen in the wild-type HFD mice. More macrophages invaded in the liver and kidney after Gpr97 knockout in HFD mice. Furthermore, the levels of TNF-alpha were higher in the liver and kidney of Gpr97(-/-) HFD mice compared to those in wild-type HFD mice. The data indicate that Gpr97 might be required for local inflammation development in obesity-relative tissues, but does not play a role in metabolic disorder in HFD-induced obesity.
C1 [Shi, Jueping; Zhang, Xiaoyu; Wang, Shaoying; Du, Bing; Liu, Mingyao; Jiang, Wenzheng; Qian, Min; Ren, Hua] E China Normal Univ, Inst Biomed Sci, Shanghai Key Lab Regulatory Biol, Shanghai 200062, Peoples R China.
   [Shi, Jueping; Zhang, Xiaoyu; Wang, Shaoying; Du, Bing; Liu, Mingyao; Jiang, Wenzheng; Qian, Min; Ren, Hua] E China Normal Univ, Sch Life Sci, Shanghai 200062, Peoples R China.
   [Wang, Jinjin; Wang, Zhugang] Shanghai Res Ctr Model Organisms, Shanghai, Peoples R China.
C3 East China Normal University; East China Normal University
RP Ren, H (corresponding author), E China Normal Univ, Inst Biomed Sci, Shanghai Key Lab Regulatory Biol, Shanghai 200062, Peoples R China.; Ren, H (corresponding author), E China Normal Univ, Sch Life Sci, Shanghai 200062, Peoples R China.
EM huaren@bio.ecnu.edu.cn
RI Zhang, Xiaoyu/K-6918-2019
OI Du, Bing/0000-0002-5402-6527; Liu, Mingyao/0000-0001-7339-5048; Jiang,
   Wenzheng/0000-0003-4999-4168
FU National Basic Research Program of China [2012CB910404]; National
   Natural Science Foundation of China [81272369, 81172816, 31470040,
   31000346]; Doctoral Fund of Ministry of Education of China
   [20130076110013]; Shanghai Committee of Science and Technology, China
   [15JC1401500, 14140904200, 15ZR1411100]
FX This work was supported by National Basic Research Program of China
   (2012CB910404); National Natural Science Foundation of China (grants
   81272369, 81172816, 31470040, 31000346); Doctoral Fund of Ministry of
   Education of China (20130076110013); the Shanghai Committee of Science
   and Technology, China (15JC1401500, 14140904200, 15ZR1411100).
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NR 48
TC 24
Z9 24
U1 2
U2 14
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD APR 19
PY 2016
VL 6
AR 24649
DI 10.1038/srep24649
PG 11
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA DJ8VM
UT WOS:000374491300001
PM 27089991
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Pertynska-Marczewska, M
   Merhi, Z
AF Pertynska-Marczewska, Magdalena
   Merhi, Zaher
TI Relationship of Advanced Glycation End Products With Cardiovascular
   Disease in Menopausal Women
SO REPRODUCTIVE SCIENCES
LA English
DT Review
DE cardiovascular disease; advanced glycation end products; RAGE; sRAGE;
   atherosclerosis; menopause
ID CORONARY-HEART-DISEASE; CIRCULATING IMMUNE-COMPLEXES; RANDOMIZED
   CONTROLLED-TRIAL; ADHESION MOLECULE-1 VCAM-1; MEDIATED PROTEIN
   GLYCATION; NECROSIS-FACTOR-ALPHA; CLASS-III REGION; FACTOR-KAPPA-B;
   SOLUBLE RAGE; POSTMENOPAUSAL WOMEN
AB Cardiovascular disease (CVD) represents the most significant cause of death in postmenopausal women. Advanced glycation end products (AGEs) are formed by nonenzymatic modification of proteins, lipids, and nucleic acids by glucose. This review focuses on the contribution of AGEs and their receptors to the development of CVD in menopause. Advanced glycation end products circulate and activate the proinflammatory endothelial cell surface receptor called RAGE, bind to the extracellular matrix of the cardiovascular system, or bind to the circulating anti-inflammatory soluble form of RAGE (sRAGE). Data emerging from human and animal studies suggest that AGEs and both receptors (RAGE and sRAGE) are implicated in the pathophysiology of CVD. Particular emphasis has been given to the role of AGE-RAGE axis in oxidative stress, inflammation, endothelial cell toxicity, and progression of atherosclerosis in menopause. Data accruing from human and animal studies suggest that RAGE expression level and circulating sRAGE level are associated with estradiol and are correlated with CVD risk factors, such as adiposity, dyslipidemia, insulin resistance, diabetes, and metabolic syndrome. By recognizing the impact of AGEs on atherosclerosis, pharmacological strategies targeting the AGE-RAGE pathway hold therapeutic potential for CVD in menopausal women.
C1 [Merhi, Zaher] Univ Vermont, Coll Med, Dept Obstet Gynecol & Reprod Sci, Div Reprod Endocrinol & Infertil, Burlington, VT USA.
C3 University of Vermont
RP Merhi, Z (corresponding author), 111 Colchester Ave, Burlington, VT 05401 USA.
EM zom00@hotmail.com
RI PERTYNSKA-MARCZEWSKA, MAGDALENA/HGB-4148-2022
FU American Society for Reproductive Medicine; Ferring Pharmaceuticals;
   University of Vermont Internal Grant
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: American
   Society for Reproductive Medicine, Ferring Pharmaceuticals, and
   University of Vermont Internal Grant to ZM.
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NR 88
TC 29
Z9 30
U1 0
U2 14
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1933-7191
EI 1933-7205
J9 REPROD SCI
JI Reprod. Sci.
PD JUL
PY 2015
VL 22
IS 7
BP 774
EP 782
DI 10.1177/1933719114549845
PG 9
WC Obstetrics & Gynecology; Reproductive Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology; Reproductive Biology
GA CN0BF
UT WOS:000358076100002
PM 25228634
OA Green Published
DA 2025-06-11
ER

PT J
AU Saijo, Y
   Utsugi, M
   Yoshioka, E
   Horikawa, N
   Sato, T
   Gong, Y
   Kishi, R
AF Saijo, Yasuaki
   Utsugi, Megumi
   Yoshioka, Eiji
   Horikawa, Naoko
   Sato, Tetsuro
   Gong, Yingyan
   Kishi, Reiko
TI The relationship of gamma-glutamyltransferase to C-reactive protein and
   arterial stiffness
SO NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
LA English
DT Article
DE gamma; glutamyltransferase; C-reactive protein; pulse wave velocity;
   arterial stiffness
ID WAVE VELOCITY-MEASUREMENT; YOUNG-ADULTS CARDIA; MIDDLE-AGED MEN;
   CORONARY-HEART-DISEASE; METABOLIC SYNDROME; AORTIC STIFFNESS; OXIDATIVE
   STRESS; RISK DEVELOPMENT; MYOCARDIAL-INFARCTION; INDEPENDENT PREDICTOR
AB Background and aims: The relationships between gamma-glutamyltransferase (GGT), C-reactive protein (CRP), and arterial stiffness have not been fully investigated. The aim of this study was to clarify whether serum GGT is related to CRP and arterial stiffness estimated using brachial-ankle pulse wave velocity (baPWV).
   Methods and results: The subjects were 3412 mates and 854 females. GGT, CRP, baPWV, and conventional risk factors were evaluated. On multiple regression analysis, after adjustment for the conventional risk factors, log GGT was significantly associated with log CRP in mate and female subjects (mate subjects: beta = 0.168, p < 0.0001; female subjects: beta = 0.098, p < 0.05). After adjustment for the conventional risk factors, log GGT was significantly associated with PWV in mate subjects (beta = 0.060, p < 0.0001), but in female subjects, no significant relationships were found after adjustment (beta = 0.007, p = 0.82).
   Conclusion: These results suggest that GGT is independently associated with an increased level of CRP in both mates and females. In addition, in mates, GGT is related to an increased level of arterial stiffness. (C) 2006 Elsevier B.V. All rights reserved.
C1 [Saijo, Yasuaki] Asahikwa Med Coll, Dept Hlth Sci, Asahikawa, Hokkaido 0788510, Japan.
   [Utsugi, Megumi; Yoshioka, Eiji; Horikawa, Naoko; Sato, Tetsuro; Gong, Yingyan; Kishi, Reiko] Hokkaido Univ, Grad Sch Med, Dept Publ Hlth, Kita Ku, Sapporo, Hokkaido 0608638, Japan.
C3 Asahikawa Medical College; Hokkaido University
RP Saijo, Y (corresponding author), Asahikwa Med Coll, Dept Hlth Sci, E2-1-1-1, Asahikawa, Hokkaido 0788510, Japan.
EM y-saijo@asahikawa-med.ac.jp
RI Yoshioka, Eiji/AAY-5495-2020; Saijo, Yasuaki/J-3796-2019
OI Saijo, Yasuaki/0000-0002-6211-8202; Yoshioka, Eiji/0000-0003-3316-1057
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NR 50
TC 34
Z9 36
U1 0
U2 0
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0939-4753
J9 NUTR METAB CARDIOVAS
JI Nutr. Metab. Carbiovasc. Dis.
PD MAR
PY 2008
VL 18
IS 3
BP 211
EP 219
DI 10.1016/j.numecd.2006.10.002
PG 9
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism; Nutrition
   & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism;
   Nutrition & Dietetics
GA 297KI
UT WOS:000255615200007
PM 17412574
OA Green Submitted
DA 2025-06-11
ER

PT J
AU McIntyre, RS
   Soczynska, JK
   Beyer, JL
   Woldeyohannes, HO
   Law, CWY
   Miranda, A
   Konarski, JZ
   Kennedy, SH
AF McIntyre, Roger S.
   Soczynska, Joanna K.
   Beyer, John L.
   Woldeyohannes, Hanna O.
   Law, Candy W. Y.
   Miranda, Andrew
   Konarski, Jakub Z.
   Kennedy, Sidney H.
TI Medical comorbidity in bipolar disorder: reprioritizing unmet needs
SO CURRENT OPINION IN PSYCHIATRY
LA English
DT Review
DE bipolar disorder; cardiovascular disease; diabetes; diabetes mellitus;
   medical comorbidity; obesity
ID METABOLIC SYNDROME; DIABETES-MELLITUS; MOOD DISORDERS;
   PSYCHOTROPIC-DRUGS; THYROID-FUNCTION; SUICIDE ATTEMPTS; INCREASED RISK;
   WEIGHT-GAIN; FOLLOW-UP; PREVALENCE
AB Purpose of review The aim of this review is to synthesize results from extant investigations which report on the co-occurrence of; bipolar disorder and medical comorbidity.
   Recent findings We conducted a MEDLINE search of all English-language articles published between January 2004 and November 2006. Most studies,, report on medical comorbidity in bipolar samples; relatively fewer studies report the reciprocal association: Individuals with bipolar disorder are differentially affected by several 'stress-sensitive' medical disorders notably circulatory disorders, obesity and l diabetes mellitus. Neurological disorders (e.g. migraine), respiratory disorders and infectious diseases are also prevalent. Although relatively few studies have scrutinized the co-occurrence of bipolar disorder in medical settings, individuals with epilepsy, multiple sclerosis, migraine and circulatory disorders may have a higher prevalence of bipolar disorder. A clustering of traditional and emerging (e.g. immunoinflammatory activation) risk factors presage somatic health issues in the bipolar disorder population. latrogenic factors and insufficient access to primary, preventive and integrated healthcare systems are also contributory.
   Summary Somatic health issues in individuals with bipolar disorder are ubiquitous, under-recognized and suboptimally treated, Facile screening for risk factors and laboratory abnormalities along with behavioral modification for reducing medical comorbidity are warranted.
C1 Univ Toronto, Dept Pharmacol & Psychiat, Toronto, ON M5T 2S8, Canada.
   Univ Toronto, Dept Psychiat, Toronto, ON, Canada.
   Univ Toronto, Dept Pharmacol, Toronto, ON, Canada.
   Univ Hlth Network, Mood Disorders Psychopharmacol Unit, Toronto, ON, Canada.
   Univ Toronto, Inst Med Sci, Toronto, ON M5S 1A1, Canada.
   Duke Univ, Dept Psychiat, Durham, NC 27706 USA.
C3 University of Toronto; University of Toronto; University of Toronto;
   University of Toronto; University Health Network Toronto; University of
   Toronto; Duke University
RP McIntyre, RS (corresponding author), Univ Toronto, Dept Pharmacol & Psychiat, 399 Bathurst St, Toronto, ON M5T 2S8, Canada.
EM roger.mcintyre@uhn.on.ca
RI Kennedy, Sidney/AGR-7227-2022; McIntyre, Roger/AAU-1000-2020; kennedy,
   sidney/Q-1926-2016
OI kennedy, sidney/0000-0001-5339-7185; Soczynska,
   Joanna/0000-0003-0003-7164
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NR 105
TC 112
Z9 120
U1 0
U2 7
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0951-7367
EI 1473-6578
J9 CURR OPIN PSYCHIATR
JI Curr. Opin. Psychiatr.
PD JUL
PY 2007
VL 20
IS 4
BP 406
EP 416
DI 10.1097/YCO.0b013e3281938102
PG 11
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 186IR
UT WOS:000247772900016
PM 17551358
DA 2025-06-11
ER

PT J
AU Malhi, H
   Bronk, SF
   Werneburg, NW
   Gores, GJ
AF Malhi, H
   Bronk, SF
   Werneburg, NW
   Gores, GJ
TI Free fatty acids induce JNK-dependent hepatocyte lipoapoptosis
SO JOURNAL OF BIOLOGICAL CHEMISTRY
LA English
DT Article
ID N-TERMINAL KINASE; PROGRAMMED CELL-DEATH; INDUCED APOPTOSIS; OXIDATIVE
   STRESS; NONALCOHOLIC STEATOHEPATITIS; SYMPATHETIC NEURONS;
   ENDOTHELIAL-CELLS; SIGNALING PATHWAY; DIRECT ACTIVATION; RAT HEPATOCYTES
AB Elevated serum free fatty acids ( FFAs) and hepatocyte lipoapoptosis are features of non-alcoholic fatty liver disease. However, the mechanism by which FFAs mediate lipoapoptosis is unclear. Because JNK activation is pivotal in both the metabolic syndrome accompanying non-alcoholic fatty liver disease and cellular apoptosis, we examined the role of JNK activation in FFA-induced lipoapoptosis. Multiple hepatocyte cell lines and primary mouse hepatocytes were treated in culture with monounsaturated fatty acids and saturated fatty acids. Despite equal cellular steatosis, apoptosis and JNK activation were greater during exposure to saturated versus monounsaturated FFAs. Inhibition of JNK, pharmacologically as well as genetically, reduced saturated FFA-mediated hepatocyte lipoapoptosis. Cell death was caspase-dependent and associated with mitochondrial membrane depolarization and cytochrome c release indicating activation of the mitochondrial pathway of apoptosis. JNK-dependent lipoapoptosis was associated with activation of Bax, a known mediator of mitochondrial dysfunction. As JNK can activate Bim, a BH3 domain-only protein capable of binding to and activating Bax, its role in lipoapoptosis was also examined. Small interfering RNA-targeted knock-down of Bim attenuated both Bax activation and cell death. Collectively the data indicate that saturated FFAs induce JNK-dependent hepatocyte lipoapoptosis by activating the proapoptotic Bcl-2 proteins Bim and Bax, which trigger the mitochondrial apoptotic pathway.
C1 Mayo Clin Coll Med, Rochester, MN 55905 USA.
C3 Mayo Clinic
RP Mayo Clin Coll Med, 200 1st St SW, Rochester, MN 55905 USA.
EM gores.gregory@mayo.edu
FU NIDDK NIH HHS [DK41876] Funding Source: Medline
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NR 50
TC 602
Z9 688
U1 1
U2 51
PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3996 USA
EI 1083-351X
J9 J BIOL CHEM
JI J. Biol. Chem.
PD APR 28
PY 2006
VL 281
IS 17
BP 12093
EP 12101
DI 10.1074/jbc.M510660200
PG 9
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 035GH
UT WOS:000236988100079
PM 16505490
OA hybrid
DA 2025-06-11
ER

PT J
AU Johnsen, HM
   Hiorth, M
   Klaveness, J
AF Johnsen, Hennie Marie
   Hiorth, Marianne
   Klaveness, Jo
TI Molecular Hydrogen Therapy-A Review on Clinical Studies and Outcomes
SO MOLECULES
LA English
DT Review
DE medical gas; hydrogen therapy; molecular hydrogen; clinical trials;
   antioxidant; human studies
ID CELL LUNG-CANCER; RICH WATER; GAS INHALATION; DOUBLE-BLIND; METABOLIC
   SYNDROME; OXIDATIVE STRESS; BODY-COMPOSITION; LIVER-FUNCTION; RAT MODEL;
   ANTIOXIDANT
AB With its antioxidant properties, hydrogen gas (H2) has been evaluated in vitro, in animal studies and in human studies for a broad range of therapeutic indications. A simple search of "hydrogen gas" in various medical databases resulted in more than 2000 publications related to hydrogen gas as a potential new drug substance. A parallel search in clinical trial registers also generated many hits, reflecting the diversity in ongoing clinical trials involving hydrogen therapy. This review aims to assess and discuss the current findings about hydrogen therapy in the 81 identified clinical trials and 64 scientific publications on human studies. Positive indications have been found in major disease areas including cardiovascular diseases, cancer, respiratory diseases, central nervous system disorders, infections and many more. The available administration methods, which can pose challenges due to hydrogens' explosive hazards and low solubility, as well as possible future innovative technologies to mitigate these challenges, have been reviewed. Finally, an elaboration to discuss the findings is included with the aim of addressing the following questions: will hydrogen gas be a new drug substance in future clinical practice? If so, what might be the administration form and the clinical indications?
C1 [Johnsen, Hennie Marie; Hiorth, Marianne; Klaveness, Jo] Univ Oslo, Dept Pharm, Sem Saelands Vei 3, N-0371 Oslo, Norway.
   [Johnsen, Hennie Marie] Nacamed AS, Oslo Sci Pk,Guastadalleen 21, N-0349 Oslo, Norway.
C3 University of Oslo
RP Johnsen, HM (corresponding author), Univ Oslo, Dept Pharm, Sem Saelands Vei 3, N-0371 Oslo, Norway.; Johnsen, HM (corresponding author), Nacamed AS, Oslo Sci Pk,Guastadalleen 21, N-0349 Oslo, Norway.
EM h.m.johnsen@farmasi.uio.no
RI Hiorth, Marianne/A-3294-2015
OI Johnsen, Hennie Marie/0000-0002-8414-0478
FU The Research Council of Norway
FX No Statement Available
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NR 98
TC 42
Z9 42
U1 15
U2 56
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1420-3049
J9 MOLECULES
JI Molecules
PD DEC
PY 2023
VL 28
IS 23
AR 7785
DI 10.3390/molecules28237785
PG 25
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA AB5X0
UT WOS:001116019700001
PM 38067515
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Golmohammadi, M
   Kheirouri, S
   Attari, VE
   Moludi, J
   Sulistyowati, R
   Nachvak, SM
   Mostafaei, R
   Mansordehghan, M
AF Golmohammadi, Mona
   Kheirouri, Sorayya
   Attari, Vahideh Ebrahimzadeh
   Moludi, Jalal
   Sulistyowati, Reny
   Nachvak, Seyed Mostafa
   Mostafaei, Roghayeh
   Mansordehghan, Maryam
TI Is there any association between dietary inflammatory index and quality
   of life? A systematic review
SO FRONTIERS IN NUTRITION
LA English
DT Review
DE anti-inflammatory diet; chronic disease; dietary inflammatory index;
   inflammation; quality of life
ID C-REACTIVE PROTEIN; MULTIPLE-SCLEROSIS; MEDITERRANEAN DIET; METABOLIC
   SYNDROME; OXIDATIVE STRESS; WESTERN DIET; NEUROTROPHIC FACTOR;
   INSULIN-RESISTANCE; CHRONIC DISEASES; GUT MICROBIOTA
AB Background: The inflammatory potential of unhealthy diets can lead to the development of chronic diseases and also exacerbating their complications. Therefore, the present systematic review aimed to evaluate the association of dietary inflammatory index (DII) and quality of life (QOL) in human subjects.Methods: A systematic search was conducted in PubMed, Web of Science, and Scopus databases, using the combination of all search terms related to DII and QOL until May 2022. All eligible human studies published in English were included.Results: Three hundred twenty-seven studies were obtained from the first systematic search of the databases although, only eight studies were eligible for the evaluation. Seven studies reported that there was a significant reverse association between DII scores and overall QOL and/or its subscales in different populations including patients with asthma, osteoarthritis, hemodialysis patients, multiple sclerosis, obese women, and also in healthy subjects. While, one study on postmenopausal women found no evidence of this association.Conclusion: This systematic review demonstrated that an anti-inflammatory diet might be associated with better QOL. However, future well-designed clinical trials can provide better conclusions especially regarding the quantifying of this relationship.
C1 [Golmohammadi, Mona; Moludi, Jalal; Nachvak, Seyed Mostafa; Mostafaei, Roghayeh; Mansordehghan, Maryam] Kermanshah Univ Med Sci, Sch Nutr Sci & Food Technol, Dept Nutr Sci, Kermanshah, Iran.
   [Kheirouri, Sorayya] Tabriz Univ Med Sci, Sch Nutr & Food Sci, Dept Community Med, Tabriz, Iran.
   [Attari, Vahideh Ebrahimzadeh] Maragheh Univ Med Sci, Dept Nutr & Food Sci, Maragheh, Iran.
   [Sulistyowati, Reny] Poltekkes Kemenkes Palangka Raya, Palangka Raya, Indonesia.
C3 Kermanshah University of Medical Sciences; Tabriz University of Medical
   Science
RP Nachvak, SM (corresponding author), Kermanshah Univ Med Sci, Sch Nutr Sci & Food Technol, Dept Nutr Sci, Kermanshah, Iran.
EM smnachvak@hotmail.com
RI Nachvak, Seyed/J-9094-2017; moludi, jalal/AAY-1321-2020; Sulistyowati,
   Reny/HIK-3723-2022; Attari, Vahideh/N-2172-2017
OI , Syam'ani/0009-0000-2955-7660; Sulistyowati, Reny/0000-0002-1328-7608
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NR 105
TC 5
Z9 5
U1 0
U2 12
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD DEC 22
PY 2022
VL 9
AR 1067468
DI 10.3389/fnut.2022.1067468
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 7P0CF
UT WOS:000908380200001
PM 36618692
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Mabry, JE
   Camden, M
   Miller, A
   Sarkar, A
   Manke, A
   Ridgeway, C
   Iridiastadi, H
   Crowder, T
   Islam, M
   Soccolich, S
   Hanowski, RJ
AF Mabry, Jessica Erin
   Camden, Matthew
   Miller, Andrew
   Sarkar, Abhijit
   Manke, Aditi
   Ridgeway, Christiana
   Iridiastadi, Hardianto
   Crowder, Tarah
   Islam, Mouyid
   Soccolich, Susan
   Hanowski, Richard J.
TI Unravelling the Complexity of Irregular Shiftwork, Fatigue and Sleep
   Health for Commercial Drivers and the Associated Implications for
   Roadway Safety
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Review
DE fatigue; sleep; safety
ID LONG-HAUL TRUCK; METABOLIC SYNDROME; VEHICLE DRIVERS; LEPTIN LEVELS;
   RISK-FACTORS; WEIGHT-GAIN; BUS DRIVERS; APNEA; WORK; PERFORMANCE
AB Fatigue can be a significant problem for commercial motor vehicle (CMV) drivers. The lifestyle of a long-haul CMV driver may include long and irregular work hours, inconsistent sleep schedules, poor eating and exercise habits, and mental and physical stress, all contributors to fatigue. Shiftwork is associated with lacking, restricted, and poor-quality sleep and variations in circadian rhythms, all shown to negatively affect driving performance through impaired in judgment and coordination, longer reaction times, and cognitive impairment. Overweight and obesity may be as high as 90% in CMV drivers, and are associated with prevalent comorbidities, including obstructive sleep apnea, hypertension, and cardiovascular and metabolic disorders. As cognitive and motor processing declines with fatigue, driver performance decreases, and the risk of errors, near crashes, and crashes increases. Tools and assessments to determine and quantify the nature, severity, and impact of fatigue and sleep disorders across a variety of environments and populations have been developed and should be critically examined before being employed with CMV drivers. Strategies to mitigate fatigue in CMV operations include addressing the numerous personal, health, and work factors contributing to fatigue and sleepiness. Further research is needed across these areas to better understand implications for roadway safety.
C1 [Mabry, Jessica Erin; Camden, Matthew; Miller, Andrew; Sarkar, Abhijit; Manke, Aditi; Ridgeway, Christiana; Iridiastadi, Hardianto; Crowder, Tarah; Islam, Mouyid; Soccolich, Susan; Hanowski, Richard J.] Virginia Tech Transportat Inst, Div Freight Transit & Heavy Vehicle Safety, Blacksburg, VA 24061 USA.
   [Iridiastadi, Hardianto] Inst Teknol Bandung, Fac Ind Technol, Bandung 40132, Indonesia.
C3 Virginia Polytechnic Institute & State University; Institute Technology
   of Bandung
RP Mabry, JE (corresponding author), Virginia Tech Transportat Inst, Div Freight Transit & Heavy Vehicle Safety, Blacksburg, VA 24061 USA.
EM emabry@vtti.vt.edu
RI iridiastadi, hardianto/HPE-9633-2023; Camden, Matthew/AAH-9080-2021;
   Islam, Mouyid/AAW-2456-2020
OI Sarkar, Abhijit/0000-0003-0525-5240; Hanowski,
   Richard/0000-0002-3937-3061; Iridiastadi, Hardianto/0000-0002-5569-827X;
   Camden, Matthew/0000-0002-1879-0560
FU Virginia Tech Open Access Subvention Fund
FX The research team would like to acknowledge support from the Virginia
   Tech Open Access Subvention Fund, which provided necessary funding to
   allow the research paper to be shared publicly in Open Access formats.
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NR 117
TC 10
Z9 11
U1 3
U2 26
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD NOV
PY 2022
VL 19
IS 22
AR 14780
DI 10.3390/ijerph192214780
PG 12
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA 6K0IN
UT WOS:000887197500001
PM 36429498
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Celepli, S
   Çolak, B
   Celepli, P
   Bigat, I
   Batur, HG
   Soysal, F
   Karakurt, S
   Hücümenoglu, S
   Kismet, K
   Sahin, M
AF Celepli, Salih
   Colak, Bayram
   Celepli, Pinar
   Bigat, Irem
   Batur, Hatice Gul
   Soysal, Furkan
   Karakurt, Serdar
   Hucumenoglu, Sema
   Kismet, Kemal
   Sahin, Mustafa
TI Artichoke for biochemistry, histology, and gene expression in
   obstructive jaundice
SO REVISTA DA ASSOCIACAO MEDICA BRASILEIRA
LA English
DT Article
DE Liver; Obstructive jaundice; Cynara scolymus; Protective agent;
   Antioxidant
ID LEAF EXTRACT SUPPLEMENTATION; METABOLIC SYNDROME; OXIDATIVE STRESS;
   LIVER; TCF7L2-RS7903146; APOPTOSIS; TOXICITY; DISEASE; DAMAGE
AB OBJECTIVE: This study aimed to evaluate the hepatoprotective effect of artichoke leaf extract (Cynara scolymus) in experimental obstructive jaundice.
   METHODS: Rats were separated into three groups, namely, sham, control, and artichoke leaf extract. Ischemia was created for 60 min, and then liver tissue and blood samples were taken at the 90th minute of reperfusion. Artichoke leaf extract was given at a 300 mg/kg dose 2 h before the operation. Antioxidant enzyme activities and biochemical parameters were examined from the tissue and serum. Histopathological findings of the liver were scored semiquantitatively.
   RESULTS: Antioxidant enzyme activities in the artichoke leaf extract group were statistically significantly higher than that in the other two groups. Biochemical parameters, which show hepatocellular damage, were found to be similar in both sham and artichoke leaf extract groups. Although the values in the sham group were higher than the artichoke group in terms of protein and gene expressions, no statistically significant difference was found between these two groups. Regarding the hepatocellular effects of obstructive jaundice, the artichoke leaf extract group showed lower scores than the control group in all histopathological scores.
   CONCLUSION: The results of this study showed that artichoke leaf extract had a hepatoprotective effect that was associated with the antioxidant and anti-inflammatory effects of artichoke leaf extract.
C1 [Celepli, Salih] Gulhane Training & Res Hosp, Dept Gen Surg, Ankara, Turkey.
   [Colak, Bayram; Sahin, Mustafa] Selcuk Univ, Fac Med, Dept Gen Surg, Konya, Turkey.
   [Celepli, Pinar; Hucumenoglu, Sema] Ankara Numune Training & Res Hosp, Dept Pathol, Ankara, Turkey.
   [Bigat, Irem] TOBB Univ Econ & Technol, Grad Sch Sci & Technol, Dept Biomed Engn, Ankara, Turkey.
   [Batur, Hatice Gul; Karakurt, Serdar] Selcuk Univ, Sci Fac, Biochem Dept, Konya, Turkey.
   [Soysal, Furkan] Ankara Yildirim Beyazit Univ, Fac Engn & Nat Sci, Dept Chem Engn, Ankara, Turkey.
   [Kismet, Kemal] Selcuk Univ, Fac Nursing, Dept Surg Nursing, Konya, Turkey.
C3 Gulhane Training & Research Hospital; Selcuk University; Ankara Numune
   Training & Research Hospital; TOBB Ekonomi ve Teknoloji University;
   Selcuk University; Ankara Yildirim Beyazit University; Selcuk University
RP Celepli, S (corresponding author), Gulhane Training & Res Hosp, Dept Gen Surg, Ankara, Turkey.
EM dr.salih.celepli@gmail.com
RI bigat, irem/GRR-6885-2022; Celepli, Pınar/GPX-5267-2022; Celepli,
   Salih/GRJ-3903-2022; Sahin, Mustafa/MGA-0214-2025; Colak,
   Bayram/ABQ-2400-2022; Soysal, Furkan/AAA-7927-2019
OI Celepli, Pinar/0000-0001-7643-6263; colak, bayram/0000-0003-1403-6963;
   Karakurt, Serdar/0000-0002-4449-6103; Soysal, Furkan/0000-0002-2558-2014
CR Ahmadi Arezoo, 2019, Journal of Basic and Clinical Physiology and Pharmacology, V30, P20180180, DOI 10.1515/jbcpp-2018-0180
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NR 22
TC 0
Z9 0
U1 0
U2 20
PU ASSOC MEDICA BRASILEIRA
PI SAO PAULO
PA RUA SAO CARLOS DO PINHAL 324, CAIXA POSTAL 8904, SAO PAULO, SP, BRAZIL
EI 1806-9282
J9 REV ASSOC MED BRAS
JI Rev. Assoc. Med. Bras.
PY 2022
VL 68
IS 5
BP 647
EP 652
DI 10.1590/1806-9282.20220001
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 1N0PR
UT WOS:000800366600020
PM 35584490
OA gold
DA 2025-06-11
ER

PT J
AU Boskovic, M
   Zivkovic, M
   Koricanac, G
   Stanisic, J
   Zec, M
   Krga, I
   Stankovic, A
AF Boskovic, Maja
   Zivkovic, Maja
   Koricanac, Goran
   Stanisic, Jelena
   Zec, Manja
   Krga, Irena
   Stankovic, Aleksandra
TI Walnut Supplementation Restores the SIRT1-FoxO3a-MnSOD/Catalase Axis in
   the Heart, Promotes an Anti-Inflammatory Fatty Acid Profile in Plasma,
   and Lowers Blood Pressure on Fructose-Rich Diet
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Article
ID ELEMENT-BINDING PROTEIN; NF-KAPPA-B; INFLAMMATORY PATHWAYS;
   TRANSCRIPTION FACTOR; OXIDATIVE STRESS; ANGIOTENSIN-II; SIRT1; OXIDASE;
   CHREBP; METABOLISM
AB The benefits of walnut (Juglans regia) consumption for metabolic health are known, but the molecular background underlying their putative antioxidant and anti-inflammatory/immunomodulatory effects is underexplored. We assessed that walnut supplementation (6 weeks) reverted unfavorable changes of the SIRT1/FoxO3a/MnSOD/catalase axis in the heart induced by fructose-rich diet (FRD). Intriguingly, Nox4 was increased by both FRD and walnut supplementation. FRD increased the cytosolic fraction and decreased the nuclear fraction of the uniquely elucidated ChREBP in the heart. The ChREBP nuclear fraction was decreased in control rats subjected to walnuts. In addition, walnut consumption was associated with a reduction in systolic BP in FRD and a decrease in fatty acid AA/EPA and AA/DHA ratios in plasma. In summary, the protective effect of walnut supplementation was detected in male rats following the fructose-induced decrease in antioxidative/anti-inflammatory capacity of cardiac tissue and increase in plasma predictors of low-grade inflammation. The current results provide a novel insight into the relationship between nutrients, cellular energy homeostasis, and the modulators of inflammatory/immune response in metabolic syndrome, emphasizing the heart and highlighting a track for translation into nutrition and dietary therapeutic approaches against metabolic disease.
C1 [Boskovic, Maja; Zivkovic, Maja; Stankovic, Aleksandra] Univ Belgrade, VINCA Inst Nucl Sci, Natl Inst Republ Serbia, Lab Radiobiol & Mol Genet, Belgrade, Serbia.
   [Koricanac, Goran; Stanisic, Jelena] Univ Belgrade, VINCA Inst Nucl Sci, Natl Inst Republ Serbia, Lab Mol Biol & Endocrinol, Belgrade, Serbia.
   [Zec, Manja; Krga, Irena] Univ Belgrade, Inst Med Res, Natl Inst Republ Serbia, Ctr Res Excellence Nutr & Metab, Belgrade 11000, Serbia.
C3 University of Belgrade; University of Belgrade; University of Belgrade
RP Stankovic, A (corresponding author), Univ Belgrade, VINCA Inst Nucl Sci, Natl Inst Republ Serbia, Lab Radiobiol & Mol Genet, Belgrade, Serbia.
EM majab@vin.bg.ac.rs; majaz@vin.bg.ac.rs; gogi@vinca.rs;
   sjelena@vin.bg.ac.rs; manjazecimr@gmail.com; irenakrga@yahoo.com;
   alexas@vinca.rs
RI Krga, Irena/AAC-4879-2020; Korićanac, Goran/ABF-6544-2021; Stankovic,
   Aleksandra/T-1064-2018; Zivkovic, Maja/T-1038-2018; Zec,
   Manja/T-5942-2019
OI Boskovic, Maja/0000-0003-0167-2522; Krga, Irena/0000-0002-2073-2896;
   Stankovic, Aleksandra/0000-0002-1050-5913; Jakovljevic,
   Jelena/0000-0002-4365-9169; Zivkovic, Maja/0000-0002-0447-6626;
   Koricanac, Goran/0000-0002-9852-3330; Zec, Manja/0000-0001-5283-9295
FU Ministry of Education, Science and Technological Development, Republic
   of Serbia [451-03-68/2020-14/200017, 451-03-68/2020-14/200015]
FX The research was supported by the Ministry of Education, Science and
   Technological Development, Republic of Serbia, contract nos.
   451-03-68/2020-14/200017 and 451-03-68/2020-14/200015.
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NR 73
TC 10
Z9 11
U1 1
U2 8
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PD APR 22
PY 2021
VL 2021
AR 5543025
DI 10.1155/2021/5543025
PG 12
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA SW9JL
UT WOS:000664829800004
PM 33976753
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Lehtonen, S
AF Lehtonen, Sanna
TI SHIPping out diabetes-Metformin, an old friend among new SHIP2
   inhibitors
SO ACTA PHYSIOLOGICA
LA English
DT Review
DE diabetes; diabetic kidney disease; insulin resistance; insulin
   signalling; lipid phosphatase; podocyte
ID LIPID PHOSPHATASE SHIP2; ACTIVATED PROTEIN-KINASE; INOSITOL
   5-PHOSPHATASE SHIP2; ENDOTHELIAL GROWTH-FACTOR; 5'-PHOSPHATASE-2 GENE
   POLYMORPHISMS; ENDOPLASMIC-RETICULUM STRESS; URINARY ALBUMIN EXCRETION;
   INSULIN-RESISTANCE; GLUCOSE-METABOLISM; HUMAN PODOCYTES
AB SHIP2 (Src homology 2 domain-containing inositol 5 '-phosphatase 2) belongs to the family of 5 '-phosphatases. It regulates the phosphoinositide 3-kinase (PI3K)-mediated insulin signalling cascade by dephosphorylating the 5 '-position of PtdIns(3,4,5)P3 to generate PtdIns(3,4)P2, suppressing the activity of the pathway. SHIP2 mouse models and genetic studies in human propose that increased expression or activity of SHIP2 contributes to the pathogenesis of the metabolic syndrome, hypertension and type 2 diabetes. This has raised great interest to identify SHIP2 inhibitors that could be used to design new treatments for metabolic diseases. This review summarizes the central mechanisms associated with the development of diabetic kidney disease, including the role of insulin resistance, and then moves on to describe the function of SHIP2 as a regulator of metabolism in mouse models. Finally, the identification of SHIP2 inhibitors and their effects on metabolic processes in vitro and in vivo are outlined. One of the newly identified SHIP2 inhibitors is metformin, the first-line medication prescribed to patients with type 2 diabetes, further boosting the attraction of SHIP2 as a treatment target to ameliorate metabolic disorders.
C1 [Lehtonen, Sanna] Univ Helsinki, Fac Med, Dept Pathol, Helsinki, Finland.
   [Lehtonen, Sanna] Univ Helsinki, Fac Med, Res Program Clin & Mol Metab, Helsinki, Finland.
C3 University of Helsinki; University of Helsinki
RP Lehtonen, S (corresponding author), Univ Helsinki, Dept Pathol, Helsinki, Finland.
EM sanna.h.lehtonen@helsinki.fi
RI Lehtonen, Sanna/GRJ-3642-2022
OI Lehtonen, Sanna/0000-0003-4189-2415
FU Business Finland; Jane and Aatos Erkko Foundation; Juselius Foundation
FX Business Finland; the Jane and Aatos Erkko Foundation; the Juselius
   Foundation
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NR 178
TC 17
Z9 19
U1 4
U2 12
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1748-1708
EI 1748-1716
J9 ACTA PHYSIOL
JI Acta Physiol.
PD JAN
PY 2020
VL 228
IS 1
AR e13349
DI 10.1111/apha.13349
EA AUG 2019
PG 22
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA KG4OB
UT WOS:000480724500001
PM 31342643
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU González-Rodríguez, A
   Santamaría, B
   Mas-Gutierrez, JA
   Rada, P
   Fernández-Millán, E
   Pardo, V
   Alvarez, C
   Cuadrado, A
   Ros, M
   Serrano, M
   Valverde, AM
AF Gonzalez-Rodriguez, Agueda
   Santamaria, Beatriz
   Antonio Mas-Gutierrez, Jose
   Rada, Patricia
   Fernandez-Millan, Elisa
   Pardo, Virginia
   Alvarez, Carmen
   Cuadrado, Antonio
   Ros, Manuel
   Serrano, Manuel
   Valverde, Angela M.
TI Resveratrol treatment restores peripheral insulin sensitivity in
   diabetic mice in a sirt1-independent manner
SO MOLECULAR NUTRITION & FOOD RESEARCH
LA English
DT Article
DE Hyperglycaemia; Insulin resistance; Resveratrol; Sirt1; PTP1B
ID TYROSINE-PHOSPHATASE 1B; OXIDATIVE STRESS; RESISTANT CONDITIONS;
   GLUCOSE-HOMEOSTASIS; METABOLIC SYNDROME; SIRT1; PROTECTS; DISEASE;
   INFLAMMATION; PGC-1-ALPHA
AB ScopeMice with deletion of insulin receptor substrate (IRS) 2 develop hyperglycaemia, impaired hepatic insulin signaling and elevated gluconeogenesis. Protein tyrosine phosphatase 1B (PTP1B) inhibition by resveratrol improves peripheral insulin sensitivity of these mice. Although resveratrol activates Sirtuin1 (Sirt1), the mechanisms underlying its beneficial effects are not totally elucidated. In this study, we have investigated whether Sirt1 mediates the effects of resveratrol in controlling insulin resistance in diabetic mice.
   Methods and resultsWe attempted to ameliorate peripheral insulin resistance in two diabetic models, Irs2-deficient (Irs2(-/-)) mice and streptozotocin (STZ)-injected mice by resveratrol treatment or Sirt1 overexpression. Resveratrol improved systemic insulin sensitivity of Irs2-deficient mice. Irs2-deficient mice are characterized by high levels of PTP1B expression in liver and muscle. Interestingly, resveratrol decreased PTP1B in both tissues, thereby restoring IRS1-mediated insulin signaling. Moreover, resveratrol also restored insulin sensitivity and hepatic insulin signaling in STZ-diabetic mice. In contrast, moderate overexpression of Sirt1 neither normalized PTP1B levels nor restored insulin signaling in Irs2-deficient mice or STZ-diabetic mice.
   ConclusionResveratrol improves peripheral insulin signaling independently of Sirt1 in diabetic mice in association with the inhibition of PTP1B and, therefore, this polyphenol could be an effective adjuvant for the treatment of diabetes.
C1 [Gonzalez-Rodriguez, Agueda; Santamaria, Beatriz; Rada, Patricia; Pardo, Virginia; Cuadrado, Antonio; Valverde, Angela M.] CSIC UAM, Inst Invest Biomed Alberto Sols, Madrid, Spain.
   [Gonzalez-Rodriguez, Agueda; Santamaria, Beatriz; Fernandez-Millan, Elisa; Pardo, Virginia; Alvarez, Carmen; Valverde, Angela M.] ISCIII, Ctr Invest Biomed Red Diabet & Enfermedades Metab, Madrid, Spain.
   [Antonio Mas-Gutierrez, Jose; Ros, Manuel] Univ Rey Juan Carlos, Fac Ciencias, Madrid, Spain.
   [Rada, Patricia; Cuadrado, Antonio] ISCIII, Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain.
   [Fernandez-Millan, Elisa; Alvarez, Carmen] Univ Complutense Madrid, Fac Farm, Dept Bioquim & Biol Mol 2, E-28040 Madrid, Spain.
   [Cuadrado, Antonio; Valverde, Angela M.] Inst Invest Sanitaria La Paz IdiPaz, Madrid, Spain.
   [Serrano, Manuel] Spanish Natl Canc Res Ctr CNIO, Madrid, Spain.
C3 Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Instituto
   de Investigaciones Biomedicas Alberto Sols (IIBM); CIBER - Centro de
   Investigacion Biomedica en Red; CIBERDEM; Instituto de Salud Carlos III;
   Universidad Rey Juan Carlos; Instituto de Salud Carlos III; CIBERNED;
   Complutense University of Madrid; Centro Nacional de Investigaciones
   Oncologicas (CNIO)
RP González-Rodríguez, A (corresponding author), Hosp Univ Santa Cristina, Inst Invest Sanitaria Princesa, Madrid, Spain.
EM aguedagr@iib.uam.es; avalverde@iib.uam.es
RI González-Rodríguez, Águeda/O-6990-2018; Alvarez, Carmen/B-2582-2015;
   FERNANDEZ MILLAN, ELISA/B-2674-2015; Pardo Marques,
   Virginia/B-3062-2015; Rada Llano, Patricia/G-7300-2015; Serrano,
   Manuel/H-2634-2015
OI Cuadrado, Antonio/0000-0002-4039-7140; Cuadrado,
   Antonio/0000-0002-3444-9012; Gonzalez-Rodriguez,
   Agueda/0000-0003-2851-2318; Alvarez, Carmen/0000-0003-1874-1045;
   FERNANDEZ MILLAN, ELISA/0000-0002-2807-3776; Martinez Valverde,
   Angela/0000-0003-1192-9045; Pardo Marques, Virginia/0000-0001-9787-8722;
   Rada Llano, Patricia/0000-0002-6731-2098; Serrano,
   Manuel/0000-0001-7177-9312; Ros, Manuel/0000-0003-2982-513X
FU Spanish Ministry of Economy and Competitivity [SAF2012-33283]; Comunidad
   de Madrid (Spain) [S2010/BMD-2423]; EFSD; Amylin Paul Langerhans Grant,
   Centro de Investigacion Biomedica en Red de Diabetes y Enfermedades
   Metabolicas Asociadas (CIBERDEM, ISCIII, Spain); CIBERDEM; Sara Borrell
   Programme (ISCIII, Spain)
FX A.M.V. is supported by grants SAF2012-33283, (Spanish Ministry of
   Economy and Competitivity), Comunidad de Madrid S2010/BMD-2423 (Spain),
   EFSD and Amylin Paul Langerhans Grant, Centro de Investigacion Biomedica
   en Red de Diabetes y Enfermedades Metabolicas Asociadas (CIBERDEM,
   ISCIII, Spain). A.G.-R., V.P., and E.F.-M. received support from
   CIBERDEM. B.S. was supported by Sara Borrell Programme (ISCIII, Spain).
   We thankfully acknowledge M. Angeles Ramos for helpful technical
   assistance.
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NR 55
TC 51
Z9 54
U1 0
U2 46
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1613-4125
EI 1613-4133
J9 MOL NUTR FOOD RES
JI Mol. Nutr. Food Res.
PD AUG
PY 2015
VL 59
IS 8
BP 1431
EP 1442
DI 10.1002/mnfr.201400933
PG 12
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA CO3KS
UT WOS:000359056700002
PM 25808216
DA 2025-06-11
ER

PT J
AU Latreille, J
   Kesse-Guyot, E
   Malvy, D
   Andreeva, V
   Galan, P
   Tschachler, E
   Hercberg, S
   Guinot, C
   Ezzedine, K
AF Latreille, Julie
   Kesse-Guyot, Emmanuelle
   Malvy, Denis
   Andreeva, Valentina
   Galan, Pilar
   Tschachler, Erwin
   Hercberg, Serge
   Guinot, Christiane
   Ezzedine, Khaled
TI Dietary Monounsaturated Fatty Acids Intake and Risk of Skin Photoaging
SO PLOS ONE
LA English
DT Article
ID ANTIOXIDANT VITAMINS; METABOLIC SYNDROME; OLIVE OIL; MECHANISMS;
   SU.VI.MAX; WOMEN; PREVENTION; MINERALS; TRIAL; FOOD
AB Background: Intake of monounsaturated fatty acids has been reported to reduce oxidative stress, insulin resistance and related inflammatory processes and may thus protect from skin photoaging. The objective of this study was to investigate the association between the risk of photoaging, monounsaturated fatty acids intake and the sources of monounsaturated fatty acids.
   Methodology/Principal Findings: A cross sectional study was conducted within the framework of the SUVIMAX cohort. The survey included 1264 women and 1655 men aged between 45 and 60 years old. Dietary monounsaturated fatty acids intakes were estimated by dietary source through at least ten 24-h diet records completed during the first 2.5 years of the follow-up period. Severity of facial skin photoaging was graded by trained investigators at baseline during a clinical examination using a 6-grade scale illustrated by photographs. A lower risk of severe photoaging was associated with higher intakes of monounsaturated fatty acids from olive oil in both sexes. Strikingly, no association was found with intake of monounsaturated fatty acids from animal sources whether from dairy products, meat or processed meat.
   Conclusion/Significance: These findings support the beneficial effect of dietary olive oil or healthy diet habits associated with olive oil consumption on the severity of facial photoaging.
C1 [Latreille, Julie; Tschachler, Erwin; Guinot, Christiane] CERIES Res Ctr Human Skin Founded CHANEL, Neuilly Sur Seine, France.
   [Latreille, Julie; Kesse-Guyot, Emmanuelle; Malvy, Denis; Andreeva, Valentina; Galan, Pilar; Hercberg, Serge; Ezzedine, Khaled] Univ Paris 13, Ctr Res Human Nutr Ile France, INRA, INSERM,U1125,CNAM,UMR U557, Paris, France.
   [Malvy, Denis] Hop St Andre, Dept Internal Med & Trop Dis, Bordeaux, France.
   [Tschachler, Erwin] Med Univ Vienna, Dept Dermatol, Vienna, Austria.
   [Hercberg, Serge] Hop Avicenne, Dept Publ Hlth, F-93009 Bobigny, France.
   [Guinot, Christiane] Univ Tours, Comp Sci Lab, Tours, France.
   [Ezzedine, Khaled] Hop St Andre, Dept Dermatol, Bordeaux, France.
C3 INRAE; Universite Paris 13; heSam Universite; Conservatoire National
   Arts & Metiers (CNAM); Institut National de la Sante et de la Recherche
   Medicale (Inserm); CHU Bordeaux; Medical University of Vienna;
   Universite Paris 13; Assistance Publique Hopitaux Paris (APHP); Hopital
   Universitaire Avicenne - APHP; Universite de Tours; CHU Bordeaux
RP Latreille, J (corresponding author), CERIES Res Ctr Human Skin Founded CHANEL, Neuilly Sur Seine, France.
EM julie.latreille@ceries-lab.com
RI Ezzedine, Khaled/A-3072-2009; MALVY, Denis/T-7930-2019; HERCBERG,
   SERGE/F-3038-2017; Andreeva, Valentina/F-2680-2017; Galan,
   Pilar/F-2908-2017; Kesse-Guyot, Emmanuelle/F-2692-2017
OI Latreille, Julie/0009-0001-1004-1864; HERCBERG,
   SERGE/0000-0002-3168-1350; Andreeva, Valentina/0000-0001-9480-5210;
   Galan, Pilar/0000-0003-1706-3107; Tschachler, Erwin/0000-0002-0248-1798;
   Kesse-Guyot, Emmanuelle/0000-0002-9715-3534; Ezzedine,
   Khaled/0000-0002-5468-4589
CR [Anonymous], 2003, NAT NUTR DAT STAND R
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NR 38
TC 28
Z9 28
U1 1
U2 14
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD SEP 6
PY 2012
VL 7
IS 9
AR e44490
DI 10.1371/journal.pone.0044490
PG 7
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 001KC
UT WOS:000308458400077
PM 22970231
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Ando, K
   Fujita, T
AF Ando, Katsuyuki
   Fujita, Toshiro
TI Pathophysiology of salt sensitivity hypertension
SO ANNALS OF MEDICINE
LA English
DT Review
DE Mineralocorticoid receptor; Rac1; salt sensitivity of blood pressure;
   sympathetic nervous system; WNK4
ID MINERALOCORTICOID RECEPTOR ACTIVATION; BLOOD-PRESSURE; ANGIOTENSIN-II;
   OXIDATIVE STRESS; BIPHASIC REGULATION; RENAL INJURY; RAC1 GTPASE;
   WEIGHT-LOSS; ALDOSTERONE; POTASSIUM
AB Dietary salt intake is the most important factor contributing to hypertension, but the salt susceptibility of blood pressure (BP) is different in individual subjects. Although the pathogenesis of salt-sensitive hypertension is heterogeneous, it is mainly attributable to an impaired renal capacity to excrete sodium (Na+). We recently identified two novel mechanisms that impair renal Na+-excreting function and result in an increase in BP. First, mineralocorticoid receptor (MR) activation in the kidney, which facilitates distal Na+ reabsorption through epithelial Na+ channel activation, causes salt-sensitive hypertension. This mechanism exists not only in models of high-aldosterone hypertension as seen in conditions of obesity or metabolic syndrome, but also in normal-or low-aldosterone type of salt-sensitive hypertension. In the latter, Rac1 activation by salt excess causes MR stimulation. Second, renospecific sympathoactivation may cause an increase in BP under conditions of salt excess. Renal beta2 adrenoceptor stimulation in the kidney leads to decreased transcription of the gene encoding WNK4, a negative regulator of Na+ reabsorption through Na+-Cl+ cotransporter in the distal convoluted tubules, resulting in salt-dependent hypertension. Abnormalities identified in these two pathways of Na+ reabsorption in the distal nephron may present therapeutic targets for the treatment of salt-sensitive hypertension.
C1 [Fujita, Toshiro] Univ Tokyo, Grad Sch Med, Dept Nephrol & Endocrinol, Bunkyo Ku, 7-3-1 Hongo, Tokyo 113865, Japan.
C3 University of Tokyo
RP Fujita, T (corresponding author), Univ Tokyo, Grad Sch Med, Dept Nephrol & Endocrinol, Bunkyo Ku, 7-3-1 Hongo, Tokyo 113865, Japan.
EM fujita-dis@h.u-tokyo.ac.jp
FU Grants-in-Aid for Scientific Research [24659410, 21229012, 22590908]
   Funding Source: KAKEN
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NR 61
TC 49
Z9 61
U1 0
U2 18
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0785-3890
EI 1365-2060
J9 ANN MED
JI Ann. Med.
PD JUN
PY 2012
VL 44
SU 1
BP S119
EP S126
DI 10.3109/07853890.2012.671538
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 961LG
UT WOS:000305465300016
PM 22713140
DA 2025-06-11
ER

PT J
AU Mahmoud, MF
   El-Nagar, M
   El-Bassossy, HM
AF Mahmoud, Mona F.
   El-Nagar, Mohamed
   El-Bassossy, Hany M.
TI Anti-inflammatory Effect of Atorvastatin on Vascular Reactivity and
   Insulin Resistance in Fructose Fed Rats
SO ARCHIVES OF PHARMACAL RESEARCH
LA English
DT Article
DE Insulin resistance; Aorta; Relaxation; Contraction; Atorvastatin;
   Fructose
ID ENDOTHELIUM-DEPENDENT RELAXATION; NECROSIS-FACTOR-ALPHA;
   HYPERTENSIVE-RATS; METABOLIC SYNDROME; DIETARY FRUCTOSE; OXIDATIVE
   STRESS; ANGIOTENSIN-II; DIABETIC RATS; DYSFUNCTION; MECHANISMS
AB We investigated the possible protective effect of atorvastatin against vascular dysfunction associated with insulin resistance (IR) in fructose-fed model rats. The effect of atorvastatin (10 mg/kg/day for 8 weeks) on vascular reactivity, glucose, cholesterol, insulin, and the IR index in a well-established model of dietary hypertriglyceridemia, the fructose-fed rat, was investigated. Fructose feeding (10% fructose in drinking water for 8 weeks) induced hypercholesterolemia and hyperinsulinemia without any change in blood glucose levels. Fructose feeding also elevated serum tumor necrosis factor-alpha (TNF-alpha), the insulin resistance index, leukocyte infiltration, and endothelial cell pyknosis. Fructose feeding induced hyper-responsiveness to both phenylephrine (PE), KCl, and hyporesponsiveness to acetylcholine (Ach) but not to sodium nitroprusside-induced relaxation. Atorvastatin, given concurrently with fructose, reduced hypercholesterolemia, hyperinsulinemia, TNF-alpha level, and the IR index. It also reduced leukocyte infiltration and endothelial cell pyknosis and decreased hyper-responsiveness to both PE and KCl but did not affect hyporesponsiveness to Ach relaxation. In conclusion, atorvastatin protected against impairment in aortic vascular reactivity associated with insulin resistance, particularly increased contractility, but not reduced endothelium-dependent relaxation, by a mechanism involving a reduction in cholesterol and IR in addition to anti-inflammatory effects.
C1 [Mahmoud, Mona F.; El-Bassossy, Hany M.] Zagazig Univ, Dept Pharmacol, Fac Pharm, Zagazig 44519, Egypt.
   [El-Nagar, Mohamed] Univ Minia, Dept Pharmacol, Fac Pharm, Al Minya, Egypt.
   [El-Bassossy, Hany M.] Wake Forest Univ, Baptist Med Ctr, Hypertens Ctr, Winston Salem, NC 27103 USA.
C3 Egyptian Knowledge Bank (EKB); Zagazig University; Egyptian Knowledge
   Bank (EKB); Minia University; Wake Forest University; Wake Forest
   Baptist Medical Center
RP Mahmoud, MF (corresponding author), Zagazig Univ, Dept Pharmacol, Fac Pharm, Zagazig 44519, Egypt.
EM mona_pharmacology@yahoo.com
RI El-Bassossy, Hany/NKQ-3705-2025; Mahmoud, Mona/Q-8851-2019; Elnagar,
   Mohamed/ABC-1741-2021; El-Bassossy, Hany/I-1576-2012
OI El-Bassossy, Hany/0000-0002-6838-6945; Mahmoud, Mona/0000-0002-5312-2066
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NR 49
TC 34
Z9 38
U1 0
U2 10
PU PHARMACEUTICAL SOC KOREA
PI SEOUL
PA 1489-3 SUHCHO-DONG, SUHCHO-KU, SEOUL 137-071, SOUTH KOREA
SN 0253-6269
J9 ARCH PHARM RES
JI Arch. Pharm. Res.
PD JAN
PY 2012
VL 35
IS 1
BP 155
EP 162
DI 10.1007/s12272-012-0117-8
PG 8
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 885CY
UT WOS:000299757300019
PM 22297754
DA 2025-06-11
ER

PT J
AU Hott, CD
   Santos, BC
   Hebert, JR
   Zhao, LG
   Wirth, MD
   Vilela, EG
   Anastácio, LR
AF Hott, Cristina de Almeida
   Santos, Barbara Chaves
   Hebert, James R.
   Zhao, Longgang
   Wirth, Michael D.
   Vilela, Eduardo Garcia
   Anastacio, Lucilene Rezende
TI Dietary inflammatory index after liver transplantation: Associated
   effects and long-term outcomes
SO CLINICAL NUTRITION ESPEN
LA English
DT Article
DE Liver transplant; Chronic inflammation; Dietary inflammatory index;
   Clinical outcomes
ID METABOLIC SYNDROME; CANCER-RISK; COLORECTAL-CANCER; OXIDATIVE STRESS;
   POPULATION; CONSUMPTION; COMPONENTS; DISEASE; NUT
AB Background & aims: We examined the dietary inflammatory potential in patients who underwent liver transplantation (LTx), associated factors and its relationship with clinical outcomes ten years after the initial evaluation. Methods: Dietary Inflammatory Index (DII (R)) scores were generated from data derived from the 24-h recall in 108 patients. Results: Patients with higher DII scores (highest tertile), indicating a pro-inflammatory diet, had significantly higher serum LDL cholesterol (108.0 vs 78.2 mg/dL, p = <0.01) at the initial evaluation. However, DII scores did not significantly predict the occurrence of clinical outcomes after ten years of follow-up. Patient age was predictive of neoplasia (OR:1.05 95% CI:1.00-1.11; p = 0.03). Higher BMI at the initial evaluation was associated with steatosis (OR:1.51; 95% CI:1.29-1.77; p < 0.01), and smoking history was associated with the occurrence of cardiovascular events (OR:7.71; 95% CI:1.53-38.79; p = 0.01). Conclusions: A pro-inflammatory diet was associated with higher serum LDL cholesterol in the initial evaluation but may not be strongly related to clinical outcomes during long-term follow-up. (c) 2024 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights reserved.
C1 [Hott, Cristina de Almeida; Santos, Barbara Chaves; Anastacio, Lucilene Rezende] Univ Fed Minas Gerais, Fac Pharm, Dept Food Sci, Belo Horizonte, MG, Brazil.
   [Hebert, James R.; Zhao, Longgang; Wirth, Michael D.] Univ South Carolina, Canc Prevent & Control Program, Columbia, SC USA.
   [Hebert, James R.; Zhao, Longgang; Wirth, Michael D.] Univ South Carolina, Dept Epidemiol & Biostat, Columbia, SC USA.
   [Wirth, Michael D.] Univ South Carolina, Coll Nursing, Columbia, SC USA.
   [Vilela, Eduardo Garcia] Univ Fed Minas Gerais, Sch Med, Dept Med Clin, Belo Horizonte, MG, Brazil.
   [Anastacio, Lucilene Rezende] Univ Fed Minas Gerais, Sch Pharm, Dept Foods, Ave Presidente Antonio Carlos,6627 Campus Pampulha, BR-31270901 Belo Horizonte, Brazil.
C3 Universidade Federal de Minas Gerais; University of South Carolina
   System; University of South Carolina Columbia; University of South
   Carolina System; University of South Carolina Columbia; University of
   South Carolina System; University of South Carolina Columbia;
   Universidade Federal de Minas Gerais; Universidade Federal de Minas
   Gerais
RP Anastácio, LR (corresponding author), Univ Fed Minas Gerais, Sch Pharm, Dept Foods, Ave Presidente Antonio Carlos,6627 Campus Pampulha, BR-31270901 Belo Horizonte, Brazil.
EM lucilene.rezende@gmail.com
RI Hebert, James/IUO-5628-2023; Vilela, Eduardo/N-6081-2019; Wirth,
   Michael/C-6330-2013; Zhao, Longgang/ABB-9175-2021; Santos,
   Bárbara/ABT-4554-2022
OI Vilela, Eduardo/0000-0002-5443-7553; Rezende Anastacio,
   Lucilene/0000-0002-2269-0722; Chaves Santos, Barbara/0000-0002-0828-9879
FU United States National Cancer Institute [U01CA272977-01]
FX Drs. Hebert and Wirth were supported, in part, by grant U01CA272977-01
   from the United States National Cancer Institute.
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NR 52
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2405-4577
J9 CLIN NUTR ESPEN
JI Clin. Nutr. ESPEN
PD JUN
PY 2024
VL 61
BP 349
EP 355
DI 10.1016/j.clnesp.2024.04.001
EA APR 2024
PG 7
WC Nutrition & Dietetics
WE Emerging Sources Citation Index (ESCI)
SC Nutrition & Dietetics
GA SG6R9
UT WOS:001233348300001
PM 38777454
DA 2025-06-11
ER

PT J
AU Tuero, C
   Becerril, S
   Ezquerro, S
   Neira, G
   Frühbeck, G
   Rodríguez, A
AF Tuero, Carlota
   Becerril, Sara
   Ezquerro, Silvia
   Neira, Gabriela
   Fruhbeck, Gema
   Rodriguez, Amaia
TI Molecular and cellular mechanisms underlying the hepatoprotective role
   of ghrelin against NAFLD progression
SO JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
LA English
DT Review
DE Ghrelin; Lipid metabolism; Programmed cell death; Kupffer cells; Hepatic
   stellate cell activation
ID NONALCOHOLIC FATTY LIVER; ACTIVATED PROTEIN-KINASE; O-ACYLTRANSFERASE
   GOAT; INSULIN-RESISTANCE; HEPATIC STEATOSIS; ACYLATED GHRELIN; PLASMA
   GHRELIN; ADIPOSE-TISSUE; LEU72MET POLYMORPHISM; HEPATOCELLULAR INJURY
AB The underlying mechanisms for the development and progression of nonalcoholic fatty liver disease (NAFLD) are complex and multifactorial. Within the last years, experimental and clinical evidences support the role of ghrelin in the development of NAFLD. Ghrelin is a gut hormone that plays a major role in the short-term regulation of appetite and long-term regulation of adiposity. The liver constitutes a target for ghrelin, where this gut-derived peptide triggers intracellular pathways regulating lipid metabolism, inflammation, and fibrosis. Interestingly, circulating ghrelin levels are altered in patients with metabolic diseases, such as obesity, type 2 diabetes, and metabolic syndrome, which, in turn, are well-known risk factors for the pathogenesis of NAFLD. This review summarizes the molecular and cellular mechanisms involved in the hepatoprotective action of ghrelin, including the reduction of hepatocyte lipotoxicity via autophagy and fatty acid p-oxidation, mitochondrial dysfunction, endoplasmic reticulum stress and programmed cell death, the reversibility of the proinflammatory phenotype in Kupffer cells, and the inactivation of hepatic stellate cells. Together, the metabolic and inflammatory pathways regulated by ghrelin in the liver support its potential as a therapeutic target to prevent NAFLD in patients with metabolic disorders.
C1 [Tuero, Carlota] Univ Navarra, Clin Univ Navarra, Sch Med, Dept Gen Surg, Pamplona, Spain.
   [Becerril, Sara; Ezquerro, Silvia; Neira, Gabriela; Fruhbeck, Gema; Rodriguez, Amaia] Clin Univ Navarra, Metab Res Lab, Irunlarrea 1, Pamplona 31008, Spain.
   [Becerril, Sara; Fruhbeck, Gema; Rodriguez, Amaia] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr CIBEROBN, Madrid, Spain.
   [Becerril, Sara; Fruhbeck, Gema; Rodriguez, Amaia] Inst Invest Sanitaria Navarra IdiSNA, Obes & Adipobiol Grp, Pamplona, Spain.
   [Fruhbeck, Gema] Clin Univ Navarra, Dept Endocrinol & Nutr, Pamplona, Spain.
C3 University of Navarra; University of Navarra; Instituto de Salud Carlos
   III; CIBER - Centro de Investigacion Biomedica en Red; CIBEROBN;
   University of Navarra
RP Rodríguez, A (corresponding author), Clin Univ Navarra, Metab Res Lab, Irunlarrea 1, Pamplona 31008, Spain.; Rodríguez, A (corresponding author), Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr CIBEROBN, Madrid, Spain.; Rodríguez, A (corresponding author), Inst Invest Sanitaria Navarra IdiSNA, Obes & Adipobiol Grp, Pamplona, Spain.
EM arodmur@unav.es
RI Ezquerro, Silvia/AAB-7587-2020; Rodriguez, Amaia/D-3044-2019
OI Neira, Gabriela/0000-0003-3826-6579; Fruhbeck, Gema/0000-0002-8305-7154;
   Tuero, Carlota/0000-0001-8577-5603; Rodriguez, Amaia/0000-0002-2180-461X
FU Fondo de Investigacion Sanitaria-FEDER from the Spanish Instituto de
   Salud Carlos III [PI19/00785, PI19/00990]
FX This work was supported by Fondo de Investigacion Sanitaria-FEDER
   (PI19/00785 and PI19/00990) from the Spanish Instituto de Salud Carlos
   III. CIBEROBN is an initiative of the Instituto de Salud Carlos III,
   Spain.
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NR 208
TC 9
Z9 9
U1 3
U2 20
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1138-7548
EI 1877-8755
J9 J PHYSIOL BIOCHEM
JI J. Physiol. Biochem.
PD NOV
PY 2023
VL 79
IS 4
BP 833
EP 849
DI 10.1007/s13105-022-00933-1
EA NOV 2022
PG 17
WC Biochemistry & Molecular Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Physiology
GA X9XV2
UT WOS:000886821900001
PM 36417140
DA 2025-06-11
ER

PT J
AU Liu, Y
   Zienkiewicz, J
   Boyd, KL
   Smith, TE
   Xu, ZQ
   Hawiger, J
AF Liu, Yan
   Zienkiewicz, Jozef
   Boyd, Kelli L.
   Smith, Taylor E.
   Xu, Zhi-Qi
   Hawiger, Jacek
TI Hyperlipidemic hypersensitivity to lethal microbial inflammation and its
   reversal by selective targeting of nuclear transport shuttles
SO SCIENTIFIC REPORTS
LA English
DT Article
ID FUNCTIONAL PEPTIDES; KNOCKOUT MICE; CHREBP; ATHEROSCLEROSIS;
   LIPOGENESIS; OBESITY
AB Hyperlipidemia, the hallmark of Metabolic Syndrome that afflicts millions of people worldwide, exacerbates life-threatening infections. We present a new evidence for the mechanism of hyperlipidemic hypersensitivity to microbial inflammation caused by pathogen-derived inducer, LPS. We demonstrate that hyperlipidemic animals succumbed to a non-lethal dose of LPS whereas normolipidemic controls survived. Strikingly, survival of hyperlipidemic animals was restored when the nuclear import of stress-responsive transcription factors (SRTFs), Sterol Regulatory Element-Binding Proteins (SREBPs), and Carbohydrate-Responsive Element-Binding Proteins (ChREBPs) was impeded by targeting the nuclear transport checkpoint with cell-penetrating, biselective nuclear transport modifier (NTM) peptide. Furthermore, the burst of proinflammatory cytokines and chemokines, microvascular endothelial injury in the liver, lungs, heart, and kidneys, and trafficking of inflammatory cells were also suppressed. To dissect the role of nuclear transport signaling pathways we designed and developed importin-selective NTM peptides. Selective targeting of the importin alpha 5, ferrying SRTFs and ChREBPs, protected 70-100% hyperlipidemic animals. Targeting importin beta 1, that transports SREBPs, was only effective after 3-week treatment that lowered blood triglycerides, cholesterol, glucose, and averted fatty liver. Thus, the mechanism of hyperlipidemic hypersensitivity to lethal microbial inflammation depends on metabolic and proinflammatory transcription factors mobilization, which can be counteracted by targeting the nuclear transport checkpoint.
C1 [Liu, Yan; Zienkiewicz, Jozef; Smith, Taylor E.; Xu, Zhi-Qi; Hawiger, Jacek] Vanderbilt Univ, Dept Med, Sch Med, Div Allergy Pulm & Crit Care Med, Nashville, TN 37235 USA.
   [Liu, Yan; Zienkiewicz, Jozef; Smith, Taylor E.; Xu, Zhi-Qi; Hawiger, Jacek] Tennessee Valley Hlth Care Syst, Dept Vet Affairs, Nashville, TN 37212 USA.
   [Boyd, Kelli L.] Vanderbilt Univ, Sch Med, Dept Pathol Microbiol & Immunol, Nashville, TN USA.
   [Hawiger, Jacek] Vanderbilt Univ, Dept Mol Physiol & Biophys, Sch Med, Nashville, TN 37235 USA.
   [Hawiger, Jacek] Vanderbilt Univ, MCN, Med Ctr, 21st Ave South,T-1218, Nashville, TN 37232 USA.
C3 Vanderbilt University; US Department of Veterans Affairs; Veterans
   Health Administration (VHA); VA Tennessee Valley Healthcare System;
   Vanderbilt University; Vanderbilt University; Vanderbilt University
RP Hawiger, J (corresponding author), Vanderbilt Univ, Dept Med, Sch Med, Div Allergy Pulm & Crit Care Med, Nashville, TN 37235 USA.; Hawiger, J (corresponding author), Tennessee Valley Hlth Care Syst, Dept Vet Affairs, Nashville, TN 37212 USA.; Hawiger, J (corresponding author), Vanderbilt Univ, Dept Mol Physiol & Biophys, Sch Med, Nashville, TN 37235 USA.; Hawiger, J (corresponding author), Vanderbilt Univ, MCN, Med Ctr, 21st Ave South,T-1218, Nashville, TN 37232 USA.
EM jack.hawiger@vumc.org
RI Zienkiewicz, Jozef/LXU-9760-2024
OI Smith, Taylor/0000-0003-4799-9440; Hawiger, Jacek/0000-0003-2721-6859
FU U.S. Department of Veterans Affairs [1I01 BX002750]; Vanderbilt
   University; Vanderbilt Ingram Cancer Center [P30 CA68485]; Vanderbilt
   Digestive Disease Research Center [DK058404]; National Institutes of
   Health/National Cancer Institute/Cancer Center Support Grant [2P30
   CA068485-14]; Vanderbilt Mouse Metabolic Phenotyping Center Grant
   [5U24DK059637-13]
FX This work was supported by the U.S. Department of Veterans Affairs
   (Grant 1I01 BX002750) and an Endowed McGavock Chair bestowed by
   Vanderbilt University. The Vanderbilt Medical Center Flow Cytometry
   Shared Resource is supported by the Vanderbilt Ingram Cancer Center
   (Grant P30 CA68485) and the Vanderbilt Digestive Disease Research Center
   (Grant DK058404). The Translational Pathology Shared Resource is
   supported by National Institutes of Health/National Cancer
   Institute/Cancer Center Support Grant 2P30 CA068485-14 and Vanderbilt
   Mouse Metabolic Phenotyping Center Grant 5U24DK059637-13.
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Z9 5
U1 0
U2 2
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD JUN 7
PY 2021
VL 11
IS 1
AR 11907
DI 10.1038/s41598-021-91395-w
PG 17
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA SU1AA
UT WOS:000662871900012
PM 34099795
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Fattahi, C
   Hamada, K
   Chiang, M
   Kosuru, S
   Polavarapu, M
   Sitthichai, R
   Fan, XD
AF Fattahi, Cameron
   Hamada, Kareem
   Chiang, Mathew
   Kosuru, Sindu
   Polavarapu, Mona
   Sitthichai, Rangsun
   Fan, Xiaoduo
TI A narrative review of mindfulness-based therapy for schizophrenia,
   co-occurring substance use and comorbid cardiometabolic problems
SO PSYCHIATRY RESEARCH
LA English
DT Review
DE Mindfulness; Schizophrenia; Substance use disorder; Smoking; Obesity;
   Cardiovascular disease; Metabolic syndrome
ID STRESS REDUCTION; BRAIN STRUCTURE; USE DISORDERS; WEIGHT-LOSS;
   INTERVENTIONS; METAANALYSIS; MEDITATION; PSYCHOSIS; OVERWEIGHT; EFFICACY
AB Mindfulness-based therapy (MBT) has gained attention in recent years as a promising treatment for patients with schizophrenia for whom traditional interventions are not effective. Research demonstrates improvements in psychotic symptoms, emotion regulation, and other areas including re-hospitalization rates and insight into illness following MBT interventions. Yet MBT studies have not carefully reported results in patients with schizophrenia and co-occurring substance use or comorbid medical problems, bringing into question the generalizability of these findings. This narrative review explores the literature regarding the use of mindfulness based interventions for patients with schizophrenia as well as for patients with substance use disorder, cardiovascular disease, obesity, and diabetes. Findings suggest that MBTs can improve craving in substance use disorder, eating related behaviors in obesity, diabetes-related distress, and metabolic regulation in patients with diabetes. Increased insula and anterior cingulate cortex volumes and activities following MBTs might be associated with the potential benefit of MBTs in patients with schizophrenia. Our review provides a foundational basis in support of the need for future studies evaluating the safety and efficacy of MBTs for schizophrenia with co-occurring substance use disorder and/or comorbid cardiometabolic problems.
C1 [Fattahi, Cameron; Hamada, Kareem; Chiang, Mathew; Kosuru, Sindu; Polavarapu, Mona; Sitthichai, Rangsun; Fan, Xiaoduo] Univ Massachusetts, Sch Med, UMass Mem Hlth Care, Worcester, MA 01605 USA.
C3 University of Massachusetts System; University of Massachusetts
   Worcester
RP Fan, XD (corresponding author), Biotech One, Suite 100,365 Plantat St, Worcester, MA 01605 USA.
EM xiaoduo.fan@umassmed.edu
RI Fattahi, Cameron/KGK-8229-2024
OI Polavarapu, Mona/0000-0001-8812-1824; Fattahi,
   Cameron/0009-0003-2978-9498; Hamada, Kareem/0009-0003-3141-6279
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U1 1
U2 17
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0165-1781
EI 1872-7123
J9 PSYCHIAT RES
JI Psychiatry Res.
PD FEB
PY 2021
VL 296
AR 113707
DI 10.1016/j.psychres.2021.113707
EA JAN 2021
PG 6
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA XQ9ZH
UT WOS:000731898500053
PM 33421838
DA 2025-06-11
ER

PT J
AU Di Renzo, L
   Cioccoloni, G
   Salimei, PS
   Ceravolo, I
   De Lorenzo, A
   Gratteri, S
AF Di Renzo, Laura
   Cioccoloni, Giorgia
   Salimei, Paola Sinibaldi
   Ceravolo, Ida
   De Lorenzo, Antonino
   Gratteri, Santo
TI Alcoholic Beverage and Meal Choices for the Prevention of
   Noncommunicable Diseases: A Randomized Nutrigenomic Trial
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Article
ID INDUCED OXIDATIVE STRESS; INFLAMMATORY GENE-EXPRESSION; RED WINE
   CONSUMPTION; MEDITERRANEAN DIET; ENDOTHELIAL DYSFUNCTION;
   CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; HEALTHY-SUBJECTS; WHITE
   WINES; VODKA
AB Background. Noncommunicable diseases (NCDs) are the first cause of death worldwide. Mediterranean diet may play a crucial role in the prevention of NCDs, and the presence of wine in this diet could play a positive role on health. Methods. 54 healthy volunteers consumed one of the following beverages: red (RW) or white wine (WW), vodka (VDK), and/or Mediterranean meal (MeDM) and high-fat meal (HFM). Results. OxLDL-C changed significantly between baseline versus HFM, MeDM versus HFM, and HFM versus HFM + RW (p < 0 05). Significant upregulation of catalase (CAT) was observed only after RW. Conversely, WW, VDK, RW + MeDM, HF + WW, and HF + VDK determined a significant downregulation of CAT gene. Superoxide dismutase 2 (SOD2) gene expression was upregulated in WW, MeDM + VDK, and RW. Contrariwise, HFM + VDK determined a downregulation of its expression. RW, RW + MeDM, and RW + HFM caused the upregulation of glutathione peroxidase-1 (GPX1). Conclusions. Our results suggest that the association of low/moderate intake of alcohol beverages, with nutraceutical-proven effectiveness, and ethanol, in association with a Mediterranean diet, could determine a reduction of atherosclerosis risk onset through a positive modulation of antioxidant gene expression helping in the prevention of inflammatory and oxidative damages.
C1 [Di Renzo, Laura; Salimei, Paola Sinibaldi; De Lorenzo, Antonino] Univ Roma Tor Vergata, Dept Biomed & Prevent, Clin Nutr & Nutrigen Sect, Via Montpellier 1, I-00136 Rome, Italy.
   [Cioccoloni, Giorgia] Univ Roma Tor Vergata, PhD Sch Appl Med Surg Sci, Via Montpellier 1, I-00133 Rome, Italy.
   [Ceravolo, Ida] Univ Palermo, Ophthalmol Sect, Dept Expt Biomed & Clin Neurosci, Piazza Marina 61, I-90133 Palermo, Italy.
   [Gratteri, Santo] Magna Graecia Univ Catanzaro, Dept Surg & Med Sci, I-88100 Catanzaro, Germaneto, Italy.
C3 University of Rome Tor Vergata; University of Rome Tor Vergata;
   University of Palermo; Magna Graecia University of Catanzaro
RP Di Renzo, L (corresponding author), Univ Roma Tor Vergata, Dept Biomed & Prevent, Clin Nutr & Nutrigen Sect, Via Montpellier 1, I-00136 Rome, Italy.
EM laura.di.renzo@uniroma2.it
RI Di Renzo, Laura/ACB-2003-2022; Stefanadis, Christodoulos/ABH-2232-2020
OI De Lorenzo, Antonino/0000-0001-6524-4493; Stefanadis,
   Christodoulos/0000-0001-5974-6454; Cioccoloni,
   Giorgia/0000-0003-0102-9182; di renzo, laura/0000-0001-8875-6723;
   Ceravolo, Ida/0000-0002-6352-8043; GRATTERI, Santo/0000-0001-8300-5744
FU Ministry of Agriculture, Food and Forestry [DM 18829/7818/2009]
FX The authors thank Doctor Simone Falco for technical research assistance
   and the "Master of Science Degree in Physical Activity and Health
   Promotion" for their support and the involvement of their students
   finalized to their master's dissertation production. This study was
   supported by the grants from the Ministry of Agriculture, Food and
   Forestry (DM 18829/7818/2009).
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NR 68
TC 13
Z9 14
U1 0
U2 9
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PY 2018
VL 2018
AR 5461436
DI 10.1155/2018/5461436
PG 13
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA GM2PI
UT WOS:000437930700001
PM 30050655
OA hybrid, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Suárez, M
   Boqué, N
   del Bas, JM
   Mayneris-Perxachs, J
   Arola, L
   Caimari, A
AF Suarez, Manuel
   Boque, Noemi
   del Bas, Josep M.
   Mayneris-Perxachs, Jordi
   Arola, Lluis
   Caimari, Antoni
TI Mediterranean Diet and Multi-Ingredient-Based Interventions for the
   Management of Non-Alcoholic Fatty Liver Disease
SO NUTRIENTS
LA English
DT Review
DE non-alcoholic fatty liver disease; non-alcoholic steatohepatitis;
   hepatic steatosis; Mediterranean diet; multi-ingredient; polyunsaturated
   fatty acids; vitamins; synbiotics; silymarin; omics technologies
ID RANDOMIZED CONTROLLED-TRIAL; VITAMIN-E; METABOLIC SYNDROME; HEPATIC
   STEATOSIS; LIFE-STYLE; SYNBIOTIC SUPPLEMENTATION;
   CARDIOVASCULAR-DISEASE; INSULIN SENSITIVITY; OXIDATIVE STRESS;
   ADIPOSE-TISSUE
AB Non-alcoholic fatty liver disease (NAFLD) comprises a wide spectrum of hepatic disorders, from simple steatosis to hepatic necro-inflammation leading to non-alcoholic steatohepatitis (NASH). Although the prevalence of these multifactorial pathologies is continuously increasing in the population, there is still not an established methodology for their treatment other than weight loss and a change in lifestyle habits, such as a hypocaloric diet and physical exercise. In this framework, there is increasing evidence that several food bioactives and dietary patterns are effective for reversing and preventing the onset of these pathologies. Some studies have claimed that better responses are obtained when treatments are performed under a multifaceted approach, using different bioactive compounds that act against complementary targets. Thus, in this work, current strategies for treating NAFLD and NASH based on multi-ingredient-based supplements or the Mediterranean diet, a dietary pattern rich in bioactive compounds, are reviewed. Furthermore, the usefulness of omics techniques to design effective multi-ingredient nutritional interventions and to predict and monitor their response against these disorders is also discussed.
C1 [Suarez, Manuel; Arola, Lluis] Univ Rovira & Virgili, Dept Biochem & Biotechnol, Nutrigen Res Grp, Campus Sescelades, E-43007 Tarragona, Spain.
   [Boque, Noemi; del Bas, Josep M.; Mayneris-Perxachs, Jordi; Arola, Lluis; Caimari, Antoni] EURECAT Technol Ctr Catalonia, Technol Unit Nutr & Hlth, Avinguda Univ 1, Reus 43204, Spain.
C3 Universitat Rovira i Virgili
RP Caimari, A (corresponding author), EURECAT Technol Ctr Catalonia, Technol Unit Nutr & Hlth, Avinguda Univ 1, Reus 43204, Spain.
EM manuel.suarez@urv.cat; noemi.boque@eurecat.org;
   josep.delbas@eurecat.org; jordi.mayneris@eurecat.org;
   lluis.arola@urv.cat; antoni.caimari@ctns.cat
RI del Bas, Josep/K-9310-2019; Mayneris-Perxachs, Jordi/AAG-7724-2020;
   Arola, Lluis/C-6074-2011; MAYNERIS-PERXACHS, JORDI/B-2589-2018; Suarez
   Recio, Manuel/F-5039-2016
OI Arola, Lluis/0000-0003-2767-1974; MAYNERIS-PERXACHS,
   JORDI/0000-0003-3788-3815; Suarez Recio, Manuel/0000-0003-0122-8253; del
   Bas, Josep Maria/0000-0002-0700-2004; Caimari,
   Antoni/0000-0001-6144-0294; Boque, Noemi/0000-0001-7173-5512
FU ACC1O [TECCT11-1-0012]; Spanish Ministerio de Economia y Competitividad
   [AGL2013-40707-R, AGL2013-49500-EXP]
FX The work was supported by ACC1O (TECCT11-1-0012) and the Spanish
   Ministerio de Economia y Competitividad (grant numbers AGL2013-40707-R
   and AGL2013-49500-EXP).
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NR 141
TC 78
Z9 81
U1 1
U2 26
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD OCT
PY 2017
VL 9
IS 10
AR 1052
DI 10.3390/nu9101052
PG 31
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA FM0DM
UT WOS:000414629900008
PM 28937599
OA gold, Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Tafesh, ZH
   Verna, EC
AF Tafesh, Zaid H.
   Verna, Elizabeth C.
TI Managing nonalcoholic fatty liver disease in patients living with HIV
SO CURRENT OPINION IN INFECTIOUS DISEASES
LA English
DT Review
DE HIV; nonalcoholic fatty liver disease; nonalcoholic steatohepatitis;
   treatment
ID CONTROLLED ATTENUATION PARAMETER; INFECTED PATIENTS; ANTIRETROVIRAL
   THERAPY; TRANSIENT ELASTOGRAPHY; HEPATIC STEATOSIS; GUT MICROBIOTA;
   VITAMIN-E; CONTROLLED-TRIAL; RISK-FACTORS; STEATOHEPATITIS
AB Purpose of review
   Nonalcoholic fatty liver disease (NAFLD) is common among patients living with HIV and may lead to liver-related morbidity and mortality.
   Recent findings
   The prevalence of NAFLD among patients with HIV is increasingly well described due to new noninvasive techniques to quantify hepatic steatosis and fibrosis. Patients with HIV may be at increased risk of disease progression, though high-quality natural history studies are not available. The high rates of metabolic syndrome, dyslipidemia and insulin resistance may partially account for this excess risk, though the impact of HIV itself, antiretroviral medications and dysregulation of the gut-liver axis likely play important roles. Treatment of NAFLD in patients with HIV is poorly studied. Current recommendations include diet and lifestyle modifications, HIV viral suppression and limitation of hepatotoxic medications as possible. In addition, there are a large number of novel medications now in clinical trials designed to target the accumulation of hepatic fat, oxidative stress, inflammation and/or fibrosis, which will revolutionize this field.
   Summary
   Although additional work is needed to understand the natural history of NAFLD in patients with HIV and identify those at highest risk, novel treatment approaches are now being tested in this population. We may soon have effective treatments to combat this epidemic.
C1 [Tafesh, Zaid H.; Verna, Elizabeth C.] Columbia Univ, Med Ctr, Ctr Liver Dis & Transplantat, 622 West 168th St,PH 14-105, New York, NY 10032 USA.
C3 Columbia University
RP Verna, EC (corresponding author), Columbia Univ, Med Ctr, Ctr Liver Dis & Transplantat, Div Digest & Liver Dis,Med, 622 West 168th St,PH 14-105, New York, NY 10032 USA.
EM ev77@cumc.columbia.edu
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NR 63
TC 16
Z9 21
U1 1
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0951-7375
EI 1473-6527
J9 CURR OPIN INFECT DIS
JI Curr. Opin. Infect. Dis.
PD FEB
PY 2017
VL 30
IS 1
BP 12
EP 20
DI 10.1097/QCO.0000000000000344
PG 9
WC Infectious Diseases
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases
GA EI0NN
UT WOS:000392171300003
PM 27941355
DA 2025-06-11
ER

PT J
AU Kardinaal, AFM
   van Erk, MJ
   Dutman, AE
   Stroeve, JHM
   van de Steeg, E
   Bijlsma, S
   Kooistra, T
   van Ommen, B
   Wopereis, S
AF Kardinaal, Alwine F. M.
   van Erk, Marjan J.
   Dutman, Alice E.
   Stroeve, Johanna H. M.
   van de Steeg, Evita
   Bijlsma, Sabina
   Kooistra, Teake
   van Ommen, Ben
   Wopereis, Suzan
TI Quantifying phenotypic flexibility as the response to a high-fat
   challenge test in different states of metabolic health
SO FASEB JOURNAL
LA English
DT Article
DE clinical study; human physiology; nutrition; systems biology;
   eicosanoids
ID TYPE-2 DIABETES-MELLITUS; INSULIN-RESISTANCE; WEIGHT-GAIN; BODY-WEIGHT;
   GLUCOSE; TISSUE; OXIDATION; ADIPOSE; PLASMA; MEN
AB Metabolism maintains homeostasis at chronic hypercaloric conditions, activating postprandial response mechanisms, which come at the cost of adaptation processes such as energy storage, eventually with negative health consequences. This study quantified the metabolic adaptation capacity by studying challenge response curves. After a high-fat challenge, the 8 h response curves of 61 biomarkers related to adipose tissue mass and function, systemic stress, metabolic flexibility, vascular health, and glucose metabolism was compared between 3 metabolic health stages: 10 healthy men, before and after 4 wk of highfat, high-calorie diet (1300 kcal/d extra), and 9 men with metabolic syndrome (MetS). The MetS subjects had increased fasting concentrations of biomarkers representing the 3 core processes, glucose, TG, and inflammation control, and the challenge response curves ofmost biomarkers were altered. After the 4 wk hypercaloric dietary intervention, these 3 processes were not changed, as compared with the preintervention state in the healthy subjects, whereas the challenge response curves of almost all endocrine, metabolic, and inflammatory processes regulating these core processes were altered, demonstrating major molecular physiologic efforts tomaintain homeostasis. This study thus demonstrates that change in challenge response is a more sensitive biomarker of metabolic resilience than are changes in fasting concentrations.
C1 [Kardinaal, Alwine F. M.; van Erk, Marjan J.; Dutman, Alice E.; Stroeve, Johanna H. M.; van de Steeg, Evita; Bijlsma, Sabina; Kooistra, Teake; van Ommen, Ben; Wopereis, Suzan] Netherlands Org Appl Sci Res TNO, Microbiol Syst & Biol Grp, NL-3700 AJ Zeist, Netherlands.
C3 Netherlands Organization Applied Science Research
RP Wopereis, S (corresponding author), Netherlands Org Appl Sci Res TNO, Microbiol & Syst Biol, POB 360, NL-3700 AJ Zeist, Netherlands.
EM suzan.wopereis@tno.nl
FU TNO's Research Program on Healthy Nutrition
FX The authors thank the volunteers for participating in the study and H.
   Fick, D. Rouwendaal, J. Jacobs, C. Hoeflaken, A. Speulman, L. van der
   Schuit, R. Schram, and I. Klopping (Microbiology Systems and Biology
   Group, TNO) for practical work. The study was funded through TNO's
   Research Program on Healthy Nutrition. A.K., M.V.E., B.V.O., and T.K.
   designed the research; A.D. conducted the research; A.D., S.B., S.W.,
   J.S., and M.V.E. analyzed the data and performed statistical analysis;
   A.K., S.W., E.S., and M.V.E. wrote the manuscript. The authors declare
   no conflicts of interest.
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TC 67
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U1 1
U2 10
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
EI 1530-6860
J9 FASEB J
JI Faseb J.
PD NOV
PY 2015
VL 29
IS 11
BP 4600
EP 4613
DI 10.1096/fj.14-269852
PG 14
WC Biochemistry & Molecular Biology; Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA CV8EZ
UT WOS:000364514700019
PM 26198450
DA 2025-06-11
ER

PT J
AU Nagase, M
AF Nagase, Miki
TI Recent Topics on Podocytes and Aldosterone
SO JOURNAL OF RENAL NUTRITION
LA English
DT Article
ID MINERALOCORTICOID RECEPTOR ACTIVATION; SALT-SENSITIVE HYPERTENSION;
   KIDNEY-DISEASE; RAC1 GTPASE; NEPHROTIC SYNDROME; OXIDATIVE STRESS;
   INJURY; RATS; NEPHROPATHY; ARHGDIA
AB Podocyte injury is a major cause of proteinuria, a core component of chronic kidney disease. We reported that podocyte impairment underlied the early glomerulopathy in animal models of lifestyle-related diseases, such as hypertension and metabolic syndrome. Accumulating evidence suggests that overactivation of the aldosterone-mineralocorticoid receptor (MR) system has harmful effects on podocytes. We found that MR signaling was enhanced in such lifestyle-related diseases with podocyte injury and proteinuria, which were ameliorated by MR antagonist. Subsequent studies revealed that plasma aldosterone concentrations are not always increased in proteinuric conditions with renal MR activation, and the mechanisms of MR overactivation remained elusive. We recently identified a novel mechanism of Rac1-mediated podocyte impairment using RhoGDIa knockout mice; Rac1 potentiates the activity of MR in a ligand-independent manner, thereby accelerating podocyte injury. We demonstrated that the Rac1-MR pathway contributes to the ligand-independent aberrant MR activation in salt-sensitive hypertension and renal injury models. The importance of the RhoGDI alpha-Rac1-MR pathway in human glomerular disease is underscored by the findings that mutations in RhoGDIagene cause nephrotic syndrome. Our results provide evidence that the Rac1-MR signal cascade as a novel therapeutic target for chronic kidney disease. (C) 2015 by the National Kidney Foundation, Inc. All rights reserved.
C1 Juntendo Univ, Dept Anat & Life Struct, Sch Med, Bunkyo Ku, Tokyo 1138421, Japan.
C3 Juntendo University
RP Nagase, M (corresponding author), Juntendo Univ, Dept Anat & Life Struct, Sch Med, Bunkyo Ku, 2-1-1 Hongo, Tokyo 1138421, Japan.
EM minagase@juntendo.ac.jp
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NR 20
TC 2
Z9 2
U1 1
U2 2
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 1051-2276
EI 1532-8503
J9 J RENAL NUTR
JI J. Renal Nutr.
PD MAR
PY 2015
VL 25
IS 2
BP 201
EP 204
DI 10.1053/j.jrn.2014.10.016
PG 4
WC Nutrition & Dietetics; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics; Urology & Nephrology
GA CB9NV
UT WOS:000349959400023
PM 25499230
DA 2025-06-11
ER

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   Kallistratos, M. S.
   Gavras, I
   Gavras, H.
TI Sympathetic Overactivity in Hypertension and Cardiovascular Disease
SO CURRENT VASCULAR PHARMACOLOGY
LA English
DT Article
DE Sympathetic nervous system; sympathetic overactivity; microneurography;
   noradrenaline spillover; hypertension
ID OBSTRUCTIVE SLEEP-APNEA; CONGESTIVE-HEART-FAILURE; SALT-INDUCED
   HYPERTENSION; POSITIVE AIRWAY PRESSURE; ALPHA(2)-ADRENERGIC RECEPTOR
   SUBTYPES; ANGIOTENSIN-INDUCED HYPERTENSION; CHRONIC INTERMITTENT
   HYPOXIA; ADRENALINE-FORMING ENZYME; AUTONOMIC NERVOUS-SYSTEM; CHRONIC
   KIDNEY-DISEASE
AB From the first description of its anatomy by T. Willis to the novel therapeutic manipulations, it is unanimously recognized that the sympathetic nervous system (SNS) holds a crucial role in cardiovascular homeostasis. The introduction of sophisticated techniques, as microneurography and regional norepinephrine spillover provided the evidence for the role of sympathetic overactivity in various cardiovascular disease entities. Sympathetic activation is common in patients with essential hypertension and contributes to initiation, maintenance and progression of the disease and it contributes to the manifestation of its major complications. A considerable body of evidence relates SNS overactivity with high sodium intake in experimental animals and humans and the underlying mechanisms have nowadays been elucidated. SNS activity is more pronounced in patients with resistant hypertension and there are several conditions that lead to this phenomenon, as older age, kidney disease, obesity and metabolic syndrome, mental stress and sleep apnea. SNS overactivity holds also a key physiopathological role in heart failure, acute coronary syndromes and arrhythmias. Moreover, inhibition of sympathetic overactivity by various means, including central SNS suppressing drugs, peripheral alpha- and beta-adrenergic receptor blockers, or novel approaches as renal sympathetic denervation have been used successfully in the treatment of all these disorders.
C1 [Manolis, A. J.; Poulimenos, L. E.; Kallistratos, M. S.] Asklepe Gen Hosp, Dept Cardiol, Voula 16673, Greece.
   [Gavras, I; Gavras, H.] Boston Univ, Hypertens & Atherosclerosis Sect, Dept Med, Sch Med, Boston, MA 02118 USA.
C3 Boston University
RP Manolis, AJ (corresponding author), Asklepe Gen Hosp, Dept Cardiol, 1 Vas Pavlou Ave, Voula 16673, Greece.
EM ajmanol@otenet.gr
RI Poulimenos, Leonidas/GSN-3650-2022
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NR 191
TC 70
Z9 79
U1 2
U2 22
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1570-1611
EI 1875-6212
J9 CURR VASC PHARMACOL
JI Current Vascular Pharmacology
PD JAN
PY 2014
VL 12
IS 1
BP 4
EP 15
PG 12
WC Pharmacology & Pharmacy; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Cardiovascular System & Cardiology
GA AE1RY
UT WOS:000333748600003
PM 23905597
DA 2025-06-11
ER

PT J
AU Quax, RA
   Manenschijn, L
   Koper, JW
   Hazes, JM
   Lamberts, SWJ
   van Rossum, EFC
   Feelders, RA
AF Quax, Rogier A.
   Manenschijn, Laura
   Koper, Jan W.
   Hazes, Johanna M.
   Lamberts, Steven W. J.
   van Rossum, Elisabeth F. C.
   Feelders, Richard A.
TI Glucocorticoid sensitivity in health and disease
SO NATURE REVIEWS ENDOCRINOLOGY
LA English
DT Review
ID 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1; MIGRATION INHIBITORY
   FACTOR; NF-KAPPA-B; BLOOD MONONUCLEAR-CELLS; PITUITARY-ADRENAL AXIS;
   RECEPTOR-BINDING CHARACTERISTICS; PLASMA-CORTISOL CONCENTRATIONS;
   INFLAMMATORY-BOWEL-DISEASE; STEROID-RESISTANT PATIENTS; MAJOR DEPRESSIVE
   DISORDER
AB Glucocorticoids regulate many physiological processes and have an essential role in the systemic response to stress. For example, gene transcription is modulated by the glucocorticoid-glucocorticoid receptor complex via several mechanisms. The ultimate biologic responses to glucocorticoids are determined by not only the concentration of glucocorticoids but also the differences between individuals in glucocorticoid sensitivity, which is influenced by multiple factors. Differences in sensitivity to glucocorticoids in healthy individuals are partly genetically determined by functional polymorphisms of the gene that encodes the glucocorticoid receptor. Hereditary syndromes have also been identified that are associated with increased and decreased sensitivity to glucocorticoids. As a result of their anti-inflammatory properties, glucocorticoids are widely used in the treatment of allergic, inflammatory and haematological disorders. The variety in clinical responses to treatment with glucocorticoids reflects the considerable variation in glucocorticoid sensitivity between individuals. In immune-mediated disorders, proinflammatory cytokines can induce localized resistance to glucocorticoids via several mechanisms. Individual differences in how tissues respond to glucocorticoids might also be involved in the predisposition for and pathogenesis of the metabolic syndrome and mood disorders. In this Review, we summarize the mechanisms that influence glucocorticoid sensitivity in health and disease and discuss possible strategies to modulate glucocorticoid responsiveness.
C1 [Quax, Rogier A.; Manenschijn, Laura; Koper, Jan W.; Lamberts, Steven W. J.; van Rossum, Elisabeth F. C.; Feelders, Richard A.] Erasmus MC, Dept Internal Med, Div Endocrinol, NL-3015 CE Rotterdam, Netherlands.
   [Hazes, Johanna M.] Erasmus MC, Dept Rheumatol, NL-3015 CE Rotterdam, Netherlands.
C3 Erasmus University Rotterdam; Erasmus MC; Erasmus University Rotterdam;
   Erasmus MC
RP Feelders, RA (corresponding author), Erasmus MC, Dept Internal Med, Div Endocrinol, S Gravendijkwal 230, NL-3015 CE Rotterdam, Netherlands.
EM r.feelders@erasmusmc.nl
RI van Rossum, Elisabeth/AAP-9388-2020
OI van Rossum, Elisabeth/0000-0003-0120-4913
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NR 214
TC 230
Z9 250
U1 0
U2 75
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 1759-5029
EI 1759-5037
J9 NAT REV ENDOCRINOL
JI Nat. Rev. Endocrinol.
PD NOV
PY 2013
VL 9
IS 11
BP 670
EP 686
DI 10.1038/nrendo.2013.183
PG 17
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 238CI
UT WOS:000325917900009
PM 24080732
DA 2025-06-11
ER

PT J
AU De Pergola, G
   Nardecchia, A
   Giagulli, VA
   Triggiani, V
   Guastamacchia, E
   Minischetti, MC
   Silvestris, F
AF De Pergola, Giovanni
   Nardecchia, Adele
   Giagulli, Vito Angelo
   Triggiani, Vincenzo
   Guastamacchia, Edoardo
   Minischetti, Manuela Castiglione
   Silvestris, Franco
TI Obesity and Heart Failure
SO ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS
LA English
DT Article
DE Body fat distributor; heart failure; obesity; obesity paradox
ID LEFT-VENTRICULAR MASS; BLOOD-PRESSURE; CARDIOVASCULAR-DISEASE;
   BODY-COMPOSITION; WEIGHT-LOSS; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   ATHEROSCLEROSIS RISK; WAIST CIRCUMFERENCE; PHYSICAL-ACTIVITY
AB Epidemiological studies have recently shown that obesity, and abdominal obesity in particular, is an independent risk factor for the development of heart failure (HF). Higher cardiac oxidative stress is the early stage of heart dysfunction due to obesity, and it is the result of insulin resistance, altered fatty acid and glucose metabolism, and impaired mitochondrial biogenesis. Extense myocyte hypertrophy and myocardial fibrosis are early microscopic changes in patients with HF, whereas circumferential strain during the left ventricular (LV) systole, LV increase in both chamber size and wall thickness (LV hypertrophy), and LV dilatation are the early macroscopic and functional alterations in obese developing heart failure. LV hypertrophy leads to diastolic dysfunction and subendocardial ischemia in obesity, and pericardial fat has been shown to be significantly associated with LV diastolic dysfunction. Evolving abnormalities of diastolic dysfunction may include progressive hypertrophy and systolic dysfunction, and various degrees of eccentric and/or concentric LV hypertrophy may be present with time. Once HF is established, overweight and obese have a better prognosis than do their lean counterparts with the same level of cardiovascular disease, and this phenomenon is called "obesity paradox". It is mainly due to lower muscle protein degradation, brain natriuretic peptide circulating levels and cardio-respiratory fitness than normal weight patients with HF.
C1 [De Pergola, Giovanni; Nardecchia, Adele; Silvestris, Franco] Univ Bari, Sch Med, Sect Clin Oncol, Dept Biomed Sci & Human Oncol,Clin Nutr Unit, I-70124 Bari, Italy.
   [Giagulli, Vito Angelo; Triggiani, Vincenzo; Guastamacchia, Edoardo] Univ Bari, Sch Med, Interdisciplinary Dept Med, I-70124 Bari, Italy.
C3 Universita degli Studi di Bari Aldo Moro; Universita degli Studi di Bari
   Aldo Moro
RP De Pergola, G (corresponding author), Univ Bari, Sch Med, Sect Clin Oncol, Dept Biomed Sci & Human Oncol,Clin Nutr Unit, Piazza Giulio Cesare 11, I-70124 Bari, Italy.
EM gdepergola@libero.it
RI Giagulli, Vito/AAL-2543-2020; De Pergola, Giovanni/AAL-9999-2020;
   TRIGGIANI, VINCENZO/GSE-3588-2022
OI TRIGGIANI, VINCENZO/0000-0001-6308-0528; DE PERGOLA,
   Giovanni/0000-0003-0020-3273; Silvestris, Francesco/0000-0002-5555-2617
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NR 80
TC 40
Z9 40
U1 1
U2 18
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1871-5303
EI 2212-3873
J9 ENDOCR METAB IMMUNE
JI Endocr. Metab. Immune Disord.-Drug Targets
PD MAR
PY 2013
VL 13
IS 1
BP 51
EP 57
PG 7
WC Endocrinology & Metabolism; Immunology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Immunology; Pharmacology & Pharmacy
GA 110LK
UT WOS:000316443500007
PM 23369137
DA 2025-06-11
ER

PT J
AU Schwarz, E
   Guest, PC
   Rahmoune, H
   Harris, LW
   Wang, L
   Leweke, FM
   Rothermundt, M
   Bogerts, B
   Koethe, D
   Kranaster, L
   Ohrmann, P
   Suslow, T
   McAllister, G
   Spain, M
   Barnes, A
   van Beveren, NJM
   Baron-Cohen, S
   Steiner, J
   Torrey, FE
   Yolken, RH
   Bahn, S
AF Schwarz, E.
   Guest, P. C.
   Rahmoune, H.
   Harris, L. W.
   Wang, L.
   Leweke, F. M.
   Rothermundt, M.
   Bogerts, B.
   Koethe, D.
   Kranaster, L.
   Ohrmann, P.
   Suslow, T.
   McAllister, G.
   Spain, M.
   Barnes, A.
   van Beveren, N. J. M.
   Baron-Cohen, S.
   Steiner, J.
   Torrey, F. E.
   Yolken, R. H.
   Bahn, S.
TI Identification of a biological signature for schizophrenia in serum
SO MOLECULAR PSYCHIATRY
LA English
DT Article
DE biomarkers; bipolar disorder; diagnosis; major depressive disorder;
   multiplex immunoassay; schizophrenia
ID MIGRATION INHIBITORY FACTOR; SYSTEMIC-LUPUS-ERYTHEMATOSUS;
   PLACEBO-CONTROLLED TRIAL; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   OXIDATIVE STRESS; DOUBLE-BLIND; DISEASE; BIOMARKERS; INFLAMMATION
AB Biomarkers are now used in many areas of medicine but are still lacking for psychiatric conditions such as schizophrenia (SCZ). We have used a multiplex molecular profiling approach to measure serum concentrations of 181 proteins and small molecules in 250 first and recent onset SCZ, 35 major depressive disorder (MDD), 32 euthymic bipolar disorder (BPD), 45 Asperger syndrome and 280 control subjects. Preliminary analysis resulted in identification of a signature comprised of 34 analytes in a cohort of closely matched SCZ (n = 71) and control (n = 59) subjects. Partial least squares discriminant analysis using this signature gave a separation of 60-75% of SCZ subjects from controls across five independent cohorts. The same analysis also gave a separation of similar to 50% of MDD patients and 10-20% of BPD and Asperger syndrome subjects from controls. These results demonstrate for the first time that a biological signature for SCZ can be identified in blood serum. This study lays the groundwork for development of a diagnostic test that can be used as an aid for distinguishing SCZ subjects from healthy controls and from those affected by related psychiatric illnesses with overlapping symptoms. Molecular Psychiatry (2012) 17, 494-502; doi:10.1038/mp.2011.42; published online 12 April 2011
C1 [Schwarz, E.; Guest, P. C.; Rahmoune, H.; Harris, L. W.; Wang, L.; Bahn, S.] Univ Cambridge, Inst Biotechnol, Cambridge, England.
   [Leweke, F. M.; Koethe, D.; Kranaster, L.] Univ Cologne, Dept Psychiat & Psychotherapy, D-50931 Cologne, Germany.
   [Leweke, F. M.; Koethe, D.; Kranaster, L.] Heidelberg Univ, Cent Inst Mental Hlth, D-6800 Mannheim, Germany.
   [Rothermundt, M.; Ohrmann, P.; Suslow, T.] Univ Munster, Dept Psychiat, Munster, Germany.
   [Bogerts, B.; Steiner, J.] Univ Magdeburg, Dept Psychiat, D-39106 Magdeburg, Germany.
   [McAllister, G.] Psynova Neurotech Ltd, Cambridge, England.
   [Spain, M.; Barnes, A.] Rules Based Med Inc, Austin, TX USA.
   [van Beveren, N. J. M.] Erasmus Univ, Med Ctr, Dept Psychiat, Rotterdam, Netherlands.
   [Baron-Cohen, S.] Univ Cambridge, Dept Psychiat, Autism Res Ctr, Cambridge, England.
   [Torrey, F. E.; Yolken, R. H.] Stanley Med Res Inst, Chevy Chase, MD USA.
   [Bahn, S.] Erasmus Univ, Med Ctr, Dept Neurosci, Rotterdam, Netherlands.
C3 University of Cambridge; University of Cologne; Central Institute of
   Mental Health; Ruprecht Karls University Heidelberg; University of
   Munster; Otto von Guericke University; Erasmus University Rotterdam;
   Erasmus MC; University of Cambridge; Erasmus University Rotterdam;
   Erasmus MC
RP Bahn, S (corresponding author), Univ Cambridge, Inst Biotechnol, Cambridge, England.
EM sb209@cam.ac.uk
RI yolken, robert/AAW-2556-2021; Baron-Cohen, Simon/JPA-2618-2023; van Os,
   Jim/I-9496-2012; Koethe, Dagmar/G-2462-2014; Leweke, F.
   Markus/D-5435-2009
OI Koethe, Dagmar/0000-0002-8324-6756; Baron-Cohen,
   Simon/0000-0001-9217-2544; Leweke, F. Markus/0000-0002-8163-195X; Dias,
   Debora/0009-0004-6164-5360; Steiner, Johann/0000-0002-2611-2268; Harris,
   Laura/0000-0003-4312-7223; guest, paul/0000-0002-5030-7137; Suslow,
   Thomas/0000-0003-4560-0555
FU Stanley Medical Research Institute (SMRI); Psynova Neurotech; European
   Union [223427]; MRC [G0600977] Funding Source: UKRI
FX This study was supported by the Stanley Medical Research Institute
   (SMRI), Psynova Neurotech and the European Union FP7 SchizDX research
   programme (grant reference 223427). We want to thank Anke Dudeck,
   Jeanette Schadow, Dr Wolfgang Jordan, Dr Bernd Hahndorf, Dr Florian
   Kastner, Dr Anya Pedersen, Dr Ansgar Siegmund, Dr Katja Kolkebeck,
   Torsten Schoenborn, Dr Christoph W Gerth, Dr Christian Mauss, Dr Brit M
   Nolden, Dr MA Neatby, Dr Liliana Ruta and Dr Erin Ingudomnukul for their
   participation in sample characterization and collection. Thanks to all
   members of the Bahn Laboratory for discussions, help and encouragement.
   Most of all, thanks to all patients and healthy volunteers for their
   selfless donation of samples used in this study.
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NR 45
TC 178
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U2 31
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1359-4184
EI 1476-5578
J9 MOL PSYCHIATR
JI Mol. Psychiatr.
PD MAY
PY 2012
VL 17
IS 5
BP 494
EP 502
DI 10.1038/mp.2011.42
PG 9
WC Biochemistry & Molecular Biology; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Neurosciences & Neurology; Psychiatry
GA 930BN
UT WOS:000303110800004
PM 21483431
DA 2025-06-11
ER

PT J
AU Wang, ZH
   Koike, T
   Li, P
   Jiang, HY
   Natsume, Y
   Mu, L
   Chen, T
   Oshida, Y
AF Wang, Zhonghua
   Koike, Teruhiko
   Li, Ping
   Jiang, Haiying
   Natsume, Yukie
   Mu, Lan
   Chen, Tana
   Oshida, Yoshiharu
TI Effects of angiotensin II AT1 receptor inhibition and exercise training
   on insulin action in rats on high-fat diet
SO LIFE SCIENCES
LA English
DT Article
DE Insulin resistance; Angiotensin; Exercise
ID OBESE ZUCKER RATS; SKELETAL-MUSCLE; GLUCOSE-UTILIZATION; METABOLIC
   SYNDROME; OXIDATIVE STRESS; ACE-INHIBITION; DIABETIC-RATS; PPAR-GAMMA;
   RESISTANCE; SENSITIVITY
AB Aim: This study was to determine whether combination of the angiotensin II AT1 receptor blocker (ARB), candesartan cilexetil, and exercise training can prevent the development of high-fat diet-induced insulin resistance. Main methods: F344/NSlc rats were fed normal chow diet or high-fat (HF) diet for 7 weeks. The HF-fed rats were either administered candesartan cilexetil (5 mg.kg(-1) day(-1)). exercise-trained, or received a combination of these 2 treatments.
   Key findings: Oral glucose tolerance tests (OGTT) showed that combined treatment with candesartan cilexetil and exercise increased glucose tolerance as compared with each treatment alone in HF-fed rats. Moreover, euglycemic-hyperinsulinemic clamp analysis showed improvement in glucose infusion rate with exercise training or candesartan cilexetil treatment alone, and further improvement was observed with the combination treatment. Systolic blood pressure improved with candesartan cilexetil but not with exercise alone. Finally, Glut-4 protein expression in soleus muscle was decreased with HF diet, and the expression was increased by exercise and not candesartan cilexetil treatment.
   Significance: These results suggest that the combination of candesartan cilexetil and exercise training improves insulin resistance as compared with each treatment alone. Crown Copyright (C) 2011 Published by Elsevier Inc. All rights reserved.
C1 [Wang, Zhonghua; Koike, Teruhiko; Jiang, Haiying; Natsume, Yukie; Mu, Lan; Chen, Tana; Oshida, Yoshiharu] Nagoya Univ, Grad Sch Med, Dept Sports Med, Nagoya, Aichi 4648601, Japan.
   [Koike, Teruhiko; Oshida, Yoshiharu] Nagoya Univ, Res Ctr Hlth Phys Fitness & Sports, Nagoya, Aichi 4648601, Japan.
   [Wang, Zhonghua] Shenyang Med Coll, Dept Histol & Embryol, Shenyang 110034, Peoples R China.
   [Li, Ping] Aichi Canc Ctr Res Inst, Div Biochem, Nagoya, Aichi 4648681, Japan.
C3 Nagoya University; Nagoya University; Shenyang Medical College; Aichi
   Cancer Center
RP Oshida, Y (corresponding author), Nagoya Univ, Grad Sch Med, Dept Sports Med, Nagoya, Aichi 4648601, Japan.
EM oshida@htc.nagoya-u.ac.jp
RI Li, Ping/GON-7455-2022; wang, weifeng/N-4140-2013
FU Japanese Ministry of Education, Culture, Sports, Science and Technology
   [18500538, 21500682]; Shouwahoukoukai Foundation; Grants-in-Aid for
   Scientific Research [18500538, 21500682] Funding Source: KAKEN
FX This work was supported in part by research Grants-in-Aid for Scientific
   Research from the Japanese Ministry of Education, Culture, Sports,
   Science and Technology (grant nos. 18500538 and 21500682) and by funding
   from Shouwahoukoukai Foundation in 2010.
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NR 34
TC 6
Z9 6
U1 0
U2 6
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0024-3205
J9 LIFE SCI
JI Life Sci.
PD FEB 27
PY 2012
VL 90
IS 9-10
BP 322
EP 327
DI 10.1016/j.lfs.2011.11.015
PG 6
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA 902CA
UT WOS:000301015000002
PM 22210187
DA 2025-06-11
ER

EF﻿FN Clarivate Analytics Web of Science
VR 1.0
PT J
AU Hagman, DK
   Hays, LB
   Parazzoli, SD
   Poitout, V
AF Hagman, DK
   Hays, LB
   Parazzoli, SD
   Poitout, V
TI Palmitate inhibits insulin gene expression by altering PDX-1 nuclear
   localization and reducing MafA expression in isolated rat islets of
   Langerhans
SO JOURNAL OF BIOLOGICAL CHEMISTRY
LA English
DT Article
ID PANCREATIC BETA-CELLS; LONG-TERM EXPOSURE; HOMEODOMAIN TRANSCRIPTION
   FACTOR; FREE FATTY-ACIDS; OXIDATIVE STRESS; DUODENAL HOMEOBOX-1;
   SIGNAL-TRANSDUCTION; METABOLIC SYNDROME; GLUCOSE; KINASE
AB Abnormalities in lipid metabolism have been proposed as contributing factors to both defective insulin secretion from the pancreatic beta cell and peripheral insulin resistance in type 2 diabetes. Previously, we have shown that prolonged exposure of isolated rat islets of Langerhans to excessive fatty acid levels impairs insulin gene transcription. This study was designed to assess whether palmitate alters the expression and binding activity of the key regulatory factors pancreas-duodenum homeobox-1 (PDX-1), MafA, and Beta2, which respectively bind to the A3, C1, and E1 elements in the proximal region of the insulin promoter. Nuclear extracts of isolated rat islets cultured with 0.5mM palmitate exhibited reduced binding activity to the A3 and C1 elements but not the E1 element. Palmitate did not affect the overall expression of PDX-1 but reduced its nuclear localization. In contrast, palmitate blocked the stimulation of MafA mRNA and protein expression by glucose. Combined adenovirus-mediated overexpression of PDX-1 and MafA in islets completely prevented the inhibition of insulin gene expression by palmitate. These results demonstrate that prolonged exposure of islets to palmitate inhibits insulin gene transcription by impairing nuclear localization of PDX-1 and cellular expression of MafA.
C1 Pacific NW Res Inst, Seattle, WA 98122 USA.
   Univ Washington, Dept Med, Seattle, WA 98195 USA.
C3 University of Washington; University of Washington Seattle
RP Pacific NW Res Inst, 720 Broadway, Seattle, WA 98122 USA.
EM vpoitout@pnri.org
OI Poitout, Vincent/0000-0002-6555-5053
FU NIDDK NIH HHS [R56 DK058096, R01DK58096, R01 DK058096] Funding Source:
   Medline
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NR 49
TC 178
Z9 221
U1 0
U2 25
PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3996 USA
EI 1083-351X
J9 J BIOL CHEM
JI J. Biol. Chem.
PD SEP 16
PY 2005
VL 280
IS 37
BP 32413
EP 32418
DI 10.1074/jbc.M506000200
PG 6
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 963HM
UT WOS:000231794800047
PM 15944145
OA hybrid, Green Accepted
DA 2025-06-11
ER

PT J
AU van den Hoek, AM
   Özsezen, S
   Caspers, MPM
   van Koppen, A
   Hanemaaijer, R
   Verschuren, L
AF van den Hoek, Anita M.
   Ozsezen, Serdar
   Caspers, Martien P. M.
   van Koppen, Arianne
   Hanemaaijer, Roeland
   Verschuren, Lars
TI Unraveling the Transcriptional Dynamics of NASH Pathogenesis Affecting
   Atherosclerosis
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE NAFLD; NASH; inflammation; metabolic syndrome; atherosclerosis; systems
   biology; organ cross-talk
ID FATTY LIVER-DISEASE; OXIDATIVE STRESS; NONALCOHOLIC STEATOHEPATITIS;
   REDUCES ATHEROSCLEROSIS; CARDIOVASCULAR EVENTS; HEPATIC STEATOSIS;
   10-YEAR RISK; FIBROSIS; CHOLESTEROL; ASSOCIATION
AB The prevalence of non-alcoholic steatohepatitis (NASH) is rapidly increasing and associated with cardiovascular disease (CVD), the major cause of mortality in NASH patients. Although sharing common risk factors, the mechanisms by which NASH may directly contribute to the development to CVD remain poorly understood. The aim of this study is to gain insight into key molecular processes of NASH that drive atherosclerosis development. Thereto, a time-course study was performed in Ldlr-/-.Leiden mice fed a high-fat diet to induce NASH and atherosclerosis. The effects on NASH and atherosclerosis were assessed and transcriptome analysis was performed. Ldlr-/-.Leiden mice developed obesity, hyperlipidemia and insulin resistance, with steatosis and hepatic inflammation preceding atherosclerosis development. Transcriptome analysis revealed a time-dependent increase in pathways related to NASH and fibrosis followed by an increase in pro-atherogenic processes in the aorta. Gene regulatory network analysis identified specific liver regulators related to lipid metabolism (SC5D, LCAT and HMGCR), inflammation (IL1A) and fibrosis (PDGF, COL3A1), linked to a set of aorta target genes related to vascular inflammation (TNFA) and atherosclerosis signaling (CCL2 and FDFT1). The present study reveals pathogenic liver processes that precede atherosclerosis development and identifies hepatic key regulators driving the atherogenic pathways and regulators in the aorta.
C1 [van den Hoek, Anita M.; van Koppen, Arianne; Hanemaaijer, Roeland] Netherlands Org Appl Sci Res TNO, Dept Metab Hlth Res, NL-2333 CK Leiden, Netherlands.
   [Ozsezen, Serdar; Caspers, Martien P. M.; Verschuren, Lars] Netherlands Org Appl Sci Res TNO, Dept Microbiol & Syst Biol, NL-3704 HE Zeist, Netherlands.
C3 Netherlands Organization Applied Science Research; Netherlands
   Organization Applied Science Research
RP van den Hoek, AM (corresponding author), Netherlands Org Appl Sci Res TNO, Dept Metab Hlth Res, NL-2333 CK Leiden, Netherlands.
EM a.vandenhoek@tno.nl; serdar.ozsezen@tno.nl; martien.caspers@tno.nl;
   arianne.vankoppen@tno.nl; roeland.hanemaaijer@tno.nl;
   lars.verschuren@tno.nl
OI Verschuren, Lars/0000-0002-7847-9037; van den Hoek,
   Anita/0000-0002-7077-8446; Caspers, Martien/0000-0002-0248-4008
FU ZonMW [114025001]; TNO research program "Predictive Health Technologies"
FX This work was generated by a consortium that was supported by grant
   114025001 from ZonMW, and the TNO research program "Predictive Health
   Technologies".
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NR 46
TC 7
Z9 7
U1 1
U2 6
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD AUG
PY 2022
VL 23
IS 15
AR 8229
DI 10.3390/ijms23158229
PG 16
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 3T4IN
UT WOS:000840240100001
PM 35897797
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Mikolasevic, I
   Pavic, T
   Kanizaj, TF
   Bender, DV
   Domislovic, V
   Krznaric, Z
AF Mikolasevic, Ivana
   Pavic, Tajana
   Kanizaj, Tajana Filipec
   Bender, Darija Vranesic
   Domislovic, Viktor
   Krznaric, Zeljko
TI Nonalcoholic Fatty Liver Disease and Sarcopenia: Where Do We Stand?
SO CANADIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
LA English
DT Review
ID SKELETAL-MUSCLE MASS; INSULIN-RESISTANCE; NUTRITIONAL-STATUS; OLDER MEN;
   HEPATIC STEATOSIS; HANDGRIP STRENGTH; BODY-COMPOSITION; PROGNOSTIC
   VALUE; VITAMIN-D; OBESITY
AB The link between metabolic syndrome (MetS) and sarcopenia has not been extensively studied, but it is evident that they share several common features. Crucial mechanisms involved in sarcopenia-nonalcoholic fatty liver disease (NAFLD) interplay are based on effects of insulin resistance, chronic inflammation, oxidative stress, and crosstalk between organs by secretion of cytokines (hepatokines, adipokines, and myokines). Currently, published studies confirm the association of sarcopenia with the degree of NAFLD defined by liver histology. However, prospective studies that will give us information regarding the causal effect of NAFLD and sarcopenia are still needed. Furthermore, there is a need for a patient-friendly, noninvasive, low-cost method for detection of loss of skeletal muscle mass, strength, and physical performance in the context of NAFLD. Moreover, potential treatment strategies such as physical exercise and nutritional supplementation, that are usually a part of management of sarcopenia, should also be investigated in NAFLD patients, especially given the fact that for now, we do not have a good treatment option for NAFLD. Therefore, future investigations should combine studies on NAFLD and sarcopenia in terms of physical activity and nutritional interventions such as vitamin D supplementation. This review aims to report recent evidence concerning the links between sarcopenia and NAFLD and methods to assess sarcopenia.
C1 [Mikolasevic, Ivana] Univ Hosp Ctr Rijeka, Dept Gastroenterol, Rijeka, Croatia.
   [Mikolasevic, Ivana; Kanizaj, Tajana Filipec] Univ Hosp Merkur, Dept Gastroenterol, Zagreb, Croatia.
   [Mikolasevic, Ivana] Sch Med, Rijeka, Croatia.
   [Pavic, Tajana] Univ Hosp Ctr Sestre Milosrdnice, Dept Internal Med, Div Gastroenterol & Hepatol, Zagreb, Croatia.
   [Pavic, Tajana; Kanizaj, Tajana Filipec; Krznaric, Zeljko] Sch Med, Zagreb, Croatia.
   [Bender, Darija Vranesic] Univ Hosp Ctr Zagreb, Dept Internal Med, Div Gastroenterol & Hepatol, Zagreb, Croatia.
   [Bender, Darija Vranesic] Univ Hosp Ctr Zagreb, Unit Clin Nutr, Dept Internal Med, Zagreb, Croatia.
   [Domislovic, Viktor; Krznaric, Zeljko] Univ Hosp Ctr Zagreb, Dept Gastroenterol & Hepatol, Zagreb, Croatia.
C3 University of Rijeka; University of Rijeka; University of Zagreb;
   UNIVERSITY ZAGREB HOSPITAL; University of Zagreb; UNIVERSITY ZAGREB
   HOSPITAL; University of Zagreb; UNIVERSITY ZAGREB HOSPITAL
RP Mikolasevic, I (corresponding author), Univ Hosp Ctr Rijeka, Dept Gastroenterol, Rijeka, Croatia.; Mikolasevic, I (corresponding author), Univ Hosp Merkur, Dept Gastroenterol, Zagreb, Croatia.; Mikolasevic, I (corresponding author), Sch Med, Rijeka, Croatia.
EM ivana.mikolasevic@gmail.com
RI Domislovic, Viktor/ABA-5963-2020; Pavic, Tajana/B-2705-2015; Kanizaj,
   Tajana/AAQ-6438-2020
OI Vranesic Bender, Darija/0000-0001-7153-4753; Krznaric,
   Zeljko/0000-0003-3758-4540; Pavic, Tajana/0000-0002-0370-5001;
   Domislovic, Viktor/0000-0002-3715-5730
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NR 95
TC 25
Z9 26
U1 0
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2291-2789
EI 2291-2797
J9 CAN J GASTROENTEROL
JI Can. J. Gastroenterol. Hepatol.
PD NOV 2
PY 2020
VL 2020
AR 8859719
DI 10.1155/2020/8859719
PG 12
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Gastroenterology & Hepatology
GA OZ0KX
UT WOS:000594626300002
PM 33204675
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Gürcü, S
   Girgin, G
   Yorulmaz, G
   Kiliçarslan, B
   Efe, B
   Baydar, T
AF Gurcu, Sinem
   Girgin, Gozde
   Yorulmaz, Goknur
   Kilicarslan, Bilge
   Efe, Belgin
   Baydar, Terken
TI Neopterin and biopterin levels and tryptophan degradation in patients
   with diabetes
SO SCIENTIFIC REPORTS
LA English
DT Article
ID OXIDATIVE STRESS; INSULIN-RESISTANCE; METABOLIC SYNDROME; IMMUNE;
   MARKER; INFLAMMATION; METFORMIN; MELLITUS; TYPE-1; TETRAHYDROBIOPTERIN
AB This study aimed to evaluate the possible changes of neopterin, biopterin levels and tryptophan degradation in diabetes and to compare the results within diabetes groups and with healthy subjects. Diabetes mellitus patients and healthy controls were recruited the study. Patients were further subgrouped according to their drug therapy. Serum neopterin concentrations were detected by ELISA. Urinary neopterin, biopterin, serum tryptophan (Trp) and kynurenine (Kyn) levels were detected by HPLC. There was no difference between controls and diabetes patients in serum neopterin, urinary neopterin and biopterin levels (p > 0.05, all). Serum Trp and Kyn levels were significantly different in type 1 diabetes (T1DM) patients compared to controls ( p < 0.05, both). Serum neopterin levels were significantly higher in type 2 diabetes patients (T2DM) compared to T1DM (p < 0.05). Urinary biopterin levels of T2DM patients using both metformin and vildagliptin were significantly higher than T1DM patients (p < 0.05). The correlations between serum neopterin and urinary neopterin, Kyn and Kyn/ Trp were statistically significant in control and patient groups (p < 0.05, all). The study showed that Kyn/Trp was altered in diabetes patients due to immune modulation. On the other hand, although xenobiotic exposure may change pteridine levels, metformin and/ or vildagliptin use in T2DM patients did not have any effect on the measured parameters.
C1 [Gurcu, Sinem; Girgin, Gozde; Kilicarslan, Bilge; Baydar, Terken] Hacettepe Univ, Dept Toxicol, Fac Pharm, TR-9006230 Ankara, Turkey.
   [Gurcu, Sinem] Eskisehir City Hosp, Hosp Pharm, Eskisehir, Turkey.
   [Yorulmaz, Goknur; Efe, Belgin] Osmangazi Univ, Dept Endocrinol, Fac Med, Eskisehir, Turkey.
C3 Hacettepe University; Eskisehir Osmangazi University
RP Baydar, T (corresponding author), Hacettepe Univ, Dept Toxicol, Fac Pharm, TR-9006230 Ankara, Turkey.
EM tbaydar@hacettepe.edu.tr
RI BAYDAR, TERKEN/JAC-5447-2023; GIRGIN, GOZDE/J-1110-2013; Gurcu,
   Sinem/JAO-4907-2023; Baydar, Terken/J-1107-2013
OI Gurcu, Sinem/0000-0001-8534-7369; Baydar, Terken/0000-0002-5497-9600
FU University Scientific Research Foundation Unit [TBB-2016-11792]
FX This study was partially supported by the University Scientific Research
   Foundation Unit (TBB-2016-11792).
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NR 52
TC 29
Z9 29
U1 1
U2 14
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD OCT 12
PY 2020
VL 10
IS 1
AR 17025
DI 10.1038/s41598-020-74183-w
PG 8
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA OH6GP
UT WOS:000582687900005
PM 33046801
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Fang, J
   Sureda, A
   Silva, AS
   Khan, F
   Xu, SW
   Nabavi, SM
AF Fang, Jian
   Sureda, Antoni
   Silva, Ana Sanches
   Khan, Fazlullah
   Xu, Suowen
   Nabavi, Seyed Mohammed
TI Trends of tea in cardiovascular health and disease: A critical review
SO TRENDS IN FOOD SCIENCE & TECHNOLOGY
LA English
DT Review
DE Atherosclerosis; Cardiovascular diseases; Hypertension; Polyphenols; Tea
ID REDUCES BLOOD-PRESSURE; GREEN TEA; BLACK TEA; OOLONG TEA;
   EPIGALLOCATECHIN GALLATE; OXIDATIVE STRESS; ENDOTHELIAL DYSFUNCTION;
   JAPANESE POPULATION; COFFEE CONSUMPTION; METABOLIC SYNDROME
AB Background: Tea is one of the most common functional drinks in our daily life. Emerging evidence from experimental, epidemiological, and interventional studies have shown that tea consumption is inversely associated with cardiovascular disease development by reducing cardiovascular risk factors, such as hyperlipidemia, hypertension, and hyperglycemia. Tea phytochemicals exert cardiovascular protection via its anti-LDL oxidation, anti-oxidant, anti-inflammatory, anti-thrombotic, and endothelial protective effects.
   Scope and approach: In this review, we provided a timely up-to-date overview of the cardiovascular benefits and molecular mechanisms of tea and its vasoactive components in cardiovascular health and diseases. It emphasizes the importance of tea drinking as part of lifestyle modification in cardiovascular disease prevention.
   Key findings and conclusions: The health benefits of tea in cardiovascular disease prevention reported in observational and interventional studies mainly arise from the presence of various antioxidants, especially flavonoids. The molecular targets of tea and its bioactive components include Nrf2 activation and NF-kB inhibition. In addition, biotechnological advances including deep sequencing and microbiota profiling are of great value to find novel molecular targets of tea. More large-scale randomized clinical trials using bioactive compounds from tea avoiding confounding factors are necessary to confirm the effects of tea consumption in cardiovascular disease prevention.
C1 [Fang, Jian] Southern Med Univ, Huadu Dist Peoples Hosp, Dept Pharm, Guangzhou, Guangdong, Peoples R China.
   [Fang, Jian] Southern Med Univ, Huadu Dist Peoples Hosp, Dept Neurol, Guangzhou, Guangdong, Peoples R China.
   [Sureda, Antoni] Univ Balearic Isl, Res Grp Community Nutr & Oxidat Stress, E-07122 Palma De Mallorca, Spain.
   [Sureda, Antoni] Univ Balearic Isl, Lab Phys Act Sci, E-07122 Palma De Mallorca, Spain.
   [Sureda, Antoni] Inst Salud Carlos III ISCIII, CIBEROBN, E-07122 Palma De Mallorca, Spain.
   [Silva, Ana Sanches] Natl Inst Agr & Vet Res INIAV, Vila Do Conde, Portugal.
   [Silva, Ana Sanches] Univ Porto, ICETA, Ctr Study Anim Sci, Apartado 55142, P-4051401 Oporto, Portugal.
   [Khan, Fazlullah] Tehran Univ Med Sci IC TUMS, Int Campus, Tehran, Iran.
   [Khan, Fazlullah] Univ Tehran Med Sci, Inst Pharmaceut Sci TIPS, Tehran, Iran.
   [Khan, Fazlullah] Univ Tehran Med Sci, Fac Pharm, Tehran, Iran.
   [Xu, Suowen] Univ Rochester, Aab Cardiovasc Res Inst, Rochester, NY 14623 USA.
   [Nabavi, Seyed Mohammed] Baqiyatallah Univ Med Sci, Appl Biotechnol Res Ctr, Tehran, Iran.
C3 Southern Medical University - China; Southern Medical University -
   China; Universitat de les Illes Balears; Universitat de les Illes
   Balears; CIBER - Centro de Investigacion Biomedica en Red; CIBEROBN;
   Universidade do Porto; Tehran University of Medical Sciences; Tehran
   University of Medical Sciences; University of Rochester; Baqiyatallah
   University of Medical Sciences (BMSU)
RP Sureda, A (corresponding author), Univ Balearic Isl, Res Grp Community Nutr & Oxidat Stress, E-07122 Palma De Mallorca, Spain.; Sureda, A (corresponding author), Univ Balearic Isl, Lab Phys Act Sci, E-07122 Palma De Mallorca, Spain.; Sureda, A (corresponding author), Inst Salud Carlos III ISCIII, CIBEROBN, E-07122 Palma De Mallorca, Spain.; Nabavi, SM (corresponding author), Baqiyatallah Univ Med Sci, Appl Biotechnol Res Ctr, Tehran, Iran.
EM antoni.sureda@uib.es; nabavi208@gmail.com
RI Sureda, Antoni/N-9588-2019; Nabavi, Seyed Mohammad/G-5335-2010; Xu,
   Suowen/H-8697-2019; khan, Fazlullah/Q-1888-2016; Sanches Silva,
   Ana/I-1850-2015
OI Xu, Suowen/0000-0002-5488-5217; khan, Fazlullah/0000-0003-2473-6090;
   Sanches Silva, Ana/0000-0002-0226-921X; , Antoni/0000-0001-8656-6838
FU Programme of Promotion of Biomedical Research and Health Sciences
   [CIBEROBN CB12/03/30038]; American Heart Association [18CDA34110359];
   American Heart Association (AHA) [18CDA34110359] Funding Source:
   American Heart Association (AHA)
FX A. Sureda was supported by Programme of Promotion of Biomedical Research
   and Health Sciences, Project CIBEROBN CB12/03/30038. S. X. is a
   recipient of Career Development Award from American Heart Association
   (18CDA34110359).
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NR 141
TC 63
Z9 69
U1 3
U2 130
PU ELSEVIER SCIENCE LONDON
PI LONDON
PA 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND
SN 0924-2244
EI 1879-3053
J9 TRENDS FOOD SCI TECH
JI Trends Food Sci. Technol.
PD JUN
PY 2019
VL 88
BP 385
EP 396
DI 10.1016/j.tifs.2019.04.001
PG 12
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA IC6LP
UT WOS:000471083900033
DA 2025-06-11
ER

PT J
AU Trigiani, LJ
   Hamel, E
AF Trigiani, Lianne J.
   Hamel, Edith
TI An endothelial link between the benefits of physical exercise in
   dementia
SO JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
LA English
DT Review
DE Alzheimer's; dementia; endothelium; exercise; vascular cognitive
   impairment
ID RANDOMIZED CONTROLLED-TRIAL; OBSTRUCTIVE SLEEP-APNEA; CEREBRAL
   WHITE-MATTER; MILD COGNITIVE IMPAIRMENT; NITRIC-OXIDE SYNTHASE;
   BLOOD-BRAIN-BARRIER; ALZHEIMERS-DISEASE; NEUROTROPHIC-FACTOR;
   OLDER-ADULTS; AMYLOID-BETA
AB The current absence of a disease-modifying treatment for Alzheimer's disease (AD) and vascular cognitive impairment and dementia (VCID) highlights the necessity for investigating the benefits of non-pharmacological approaches such as physical exercise (PE). Although evidence exists to support an association between regular PE and higher scores on cognitive function tests, and a slower rate of cognitive decline, there is no clear consensus on the underlying molecular mechanisms of the advantages of PE. This review seeks to summarize the positive effects of PE in human and animal studies while highlighting the vascular link between these benefits. Lifestyle factors such as cardiovascular diseases, metabolic syndrome, and sleep apnea will be addressed in relation to the risk they pose in developing AD and VCID, as will molecular factors known to have an impact on either the initiation or the progression of AD and/ or VCID. This will include amyloid-beta clearance, oxidative stress, inflammatory responses, neurogenesis, angiogenesis, glucose metabolism, and white matter integrity. Particularly, this review will address how engaging in PE can counter factors that contribute to disease pathogenesis, and how these alterations are linked to endothelial cell function.
C1 [Trigiani, Lianne J.; Hamel, Edith] McGill Univ, Montreal Neurol Inst, Lab Cerebrovasc Res, Montreal, PQ, Canada.
C3 McGill University
RP Trigiani, LJ (corresponding author), 3801 Univ St, Montreal, PQ H3A 2B4, Canada.
EM lianne.trigiani@mail.mcgill.ca
FU Canadian Institute of Health research [MOP-126001]; Canadian Consortium
   on Neurodegeneration and Aging (CIHR-CCNA); CIHR studentship
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: This work
   was supported by grants from the Canadian Institute of Health research
   (MOP-126001), and the Canadian Consortium on Neurodegeneration and Aging
   (CIHR-CCNA), and a CIHR studentship (LT). The authors gratefully thank
   Drs Clotilde Lecrux and Maria Lacalle-Aurioles, and Jessika Royea for
   their insightful comments and revisions, and Susan Kaupp for her work on
   Figure 3.
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NR 160
TC 52
Z9 57
U1 0
U2 35
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0271-678X
EI 1559-7016
J9 J CEREBR BLOOD F MET
JI J. Cereb. Blood Flow Metab.
PD AUG
PY 2017
VL 37
IS 8
BP 2649
EP 2664
DI 10.1177/0271678X17714655
PG 16
WC Endocrinology & Metabolism; Hematology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Hematology; Neurosciences & Neurology
GA FC0FO
UT WOS:000406514300001
PM 28617071
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Xu, HL
   Hertzel, AV
   Steen, KA
   Bernlohr, DA
AF Xu, Hongliang
   Hertzel, Ann V.
   Steen, Kaylee A.
   Bernlohr, David A.
TI Loss of Fatty Acid Binding Protein 4/aP2 Reduces Macrophage Inflammation
   Through Activation of SIRT3
SO MOLECULAR ENDOCRINOLOGY
LA English
DT Article
ID INSULIN-RESISTANCE; ADIPOSE-TISSUE; METABOLIC SYNDROME; OXIDATIVE
   STRESS; CARDIOVASCULAR-DISEASE; AP2; OBESITY; ATHEROSCLEROSIS;
   DEFICIENCY; EXPRESSION
AB Activation of proinflammatory macrophages plays an important role in the pathogenesis of insulin resistance, type 2 diabetes, and atherosclerosis. Previous work using high fat-fed mice has shown that ablation of the adipocyte fatty acid binding protein (FABP4/aP2) in macrophages leads to an antiinflammatory state both in situ and in vivo, and the mechanism is linked, in part, to increased intracellular monounsaturated fatty acids and the up-regulation of uncoupling protein 2. Here, we show that loss of FABP4/aP2 in macrophages additionally induces sirtuin 3 (SIRT3) expression and that monounsaturated fatty acids (C16:1, C18:1) lead to increased SIRT3 protein expression. Increased expression of SirT3 in FABP4/aP2 null macrophages occurs at the protein level with no change in SirT3 mRNA. When compared with controls, silencing of SIRT3 in Raw246.7 macrophages leads to increased expression of inflammatory cytokines, inducible nitric oxide synthase and cyclooxygenase 2. In contrast, loss of SIRT3 in FABP4/aP2-deficient macrophages attenuates the suppressed inflammatory signaling, reduced reactive oxygen species production, lipopolysaccharide-induced mitochondrial dysfunction, and increased fatty acid oxidation. These results suggest that the antiinflammatory phenotype of FABP4/aP2 null mice is mediated by increased intracellular monounsaturated fatty acids leading to the increased expression of both uncoupling protein 2 and SirT3.
C1 [Xu, Hongliang; Hertzel, Ann V.; Steen, Kaylee A.; Bernlohr, David A.] Univ Minnesota, Dept Biochem Mol Biol & Biophys, Minneapolis, MN 55455 USA.
C3 University of Minnesota System; University of Minnesota Twin Cities
RP Bernlohr, DA (corresponding author), Univ Minnesota Twin Cities, Dept Biochem Mol Biol & Biophys, Minneapolis, MN 55455 USA.
EM bernl001@umn.edu
RI Xu, Hongliang/GPG-1863-2022
FU National Institutes of Health [R01 DK053189, T32 AG029796]; Minnesota
   Nutrition and Obesity Center (NIH) [P30 DK050456]; Minnesota
   Supercomputing Institute
FX This work was supported by National Institutes of Health Grants R01
   DK053189 (to D.A.B.) and T32 AG029796 (to K.A.S.) and the Minnesota
   Nutrition and Obesity Center (NIH Grant P30 DK050456). This work was
   also supported by the Minnesota Supercomputing Institute.
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NR 47
TC 59
Z9 68
U1 0
U2 20
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0888-8809
J9 MOL ENDOCRINOL
JI Mol. Endocrinol.
PD MAR
PY 2016
VL 30
IS 3
BP 325
EP 334
DI 10.1210/me.2015-1301
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA DN6SR
UT WOS:000377206900006
PM 26789108
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Caliceti, C
   Franco, P
   Spinozzi, S
   Roda, A
   Cicero, AFG
AF Caliceti, Cristiana
   Franco, Placido
   Spinozzi, Silvia
   Roda, Aldo
   Cicero, Arrigo F. G.
TI Berberine: New Insights from Pharmacological Aspects to Clinical
   Evidences in the Management of Metabolic Disorders
SO CURRENT MEDICINAL CHEMISTRY
LA English
DT Article
DE Berberine; physico-chemical properties; metabolites; bioavailability;
   safety; hyperglicemia; lipid disorders; cardiovascular disease
ID ACTIVATED PROTEIN-KINASE; DENSITY-LIPOPROTEIN RECEPTOR; GLUCAGON-LIKE
   PEPTIDE-1; FOAM CELL-FORMATION; RED-YEAST-RICE; OXIDATIVE STRESS;
   UP-REGULATION; DOUBLE-BLIND; ENDOTHELIAL FUNCTION; MECHANISM DISTINCT
AB Berberine is a quaternary ammonium salt from the protoberberine group of isoquinoline alkaloids found in such plants as gender Berberis. Berberine is recognised to improve glucose and lipid metabolism disorders and preliminary clinical evidences suggest the ability of berberine to reduce endothelial inflammation improving vascular health, even in patients already affected by cardiovascular diseases, suggesting a possible interesting role of berberine and its metabolites in clinical practice. However, its physicochemical properties, pharmacokinetic, and metabolism are not fully elucidated and contradictory data have been reported.
   This review provides a summary regarding the pharmacological and biological features of berberine, with a focus on berberine as well as their pharmacologically active metabolites and the different mechanisms underlying their activities in order to clarify the correct use of berberine supplementation, alone or in association with other nutraceuticals, for the management of metabolic disorders associated to increased cardiovascular disease risk. A particular attention has also been given to the available clinical trials assessing its short- and middle-term use tolerability, safety and efficacy in various conditions, such as dyslipidaemia, impaired fasting glucose, metabolic syndrome and type 2 diabetes.
C1 [Caliceti, Cristiana; Franco, Placido; Spinozzi, Silvia; Roda, Aldo] Univ Bologna, Dept Chem Giacomo Ciamician, Bologna, Italy.
   [Cicero, Arrigo F. G.] Univ Bologna, Dept Med & Surg Sci, I-40126 Bologna, Italy.
C3 University of Bologna; University of Bologna
RP Cicero, AFG (corresponding author), Atherosclerosis Res Unit, Poliambulatorio Pad 2,Via Albertoni 15, I-40138 Bologna, Italy.
EM arrigo.cicero@unibo.it
RI Cicero, Arrigo/H-8244-2019; caliceti, cristiana/AAW-9614-2020
OI caliceti, cristiana/0000-0002-6740-5331; Cicero, Arrigo Francesco
   Giuseppe/0000-0002-4367-3884; Roda, Aldo/0000-0001-7649-4797
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NR 123
TC 76
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U1 2
U2 43
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 0929-8673
EI 1875-533X
J9 CURR MED CHEM
JI Curr. Med. Chem.
PY 2016
VL 23
IS 14
BP 1460
EP 1476
DI 10.2174/0929867323666160411143314
PG 17
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Pharmacology &
   Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
GA DM6HI
UT WOS:000376451500005
PM 27063256
DA 2025-06-11
ER

PT J
AU Bertoni, G
   Minuti, A
   Trevisi, E
AF Bertoni, G.
   Minuti, A.
   Trevisi, E.
TI Immune system, inflammation and nutrition in dairy cattle
SO ANIMAL PRODUCTION SCIENCE
LA English
DT Article; Proceedings Paper
CT 6th Australasian Dairy Science Symposium
CY NOV 19-21, 2014
CL Hamilton, NEW ZEALAND
DE dairy cow; health; transition period
ID SUBCUTANEOUS ADIPOSE DEPOTS; MULTIPAROUS HOLSTEIN COWS; SUBACUTE RUMINAL
   ACIDOSIS; GENE NETWORK EXPRESSION; LIVER ACTIVITY INDEX; OXIDATIVE
   STRESS; NEUTROPHIL FUNCTION; TRANSITION PERIOD; GASTROINTESTINAL
   PERMEABILITY; SMARTAMINE M
AB Good health is essential for good performance and the welfare of dairy cows, and nutrition is an important component of good health. Health is influenced by the interaction between the innate adaptive components of the immune system and other factors, such as the local and systemic inflammatory response, which can sometimes be more harmful than useful. Therefore, for dairy cows, particularly those in the periparturient period, it is important to avoid, or reduce as much as possible, any kind of infectious, parasitic or metabolic disease and the associated inflammation. Such inflammation can impair cow performance by lowering milk yield, dry matter intake, fertility and energy efficiency, and can reduce liver function. Good nutrition is essential in maintaining a functional immune system, while also avoiding other causes of inflammation, such as tissue damage, and digestive and metabolic syndrome-related disorders. Provision of appropriate nutrients, such as antioxidants, omega-3 polyunsaturated fatty acids, conjugated linoleic acid and vitamin D can have anti-inflammatory effects. In the future, ways to reduce inflammation while maintaining a good immune defence must be developed and the susceptibility of the cow to diseases and inflammation evaluated. Ideally, we would be able to selectively breed for cows with a lower susceptibility to both diseases and inflammation.
C1 [Bertoni, G.; Minuti, A.; Trevisi, E.] Univ Cattolica Sacro Cuore, Fac Sci Agr Alimentari & Ambientali, Ist Zootecn, I-29122 Piacenza, Italy.
C3 Catholic University of the Sacred Heart
RP Bertoni, G (corresponding author), Univ Cattolica Sacro Cuore, Fac Sci Agr Alimentari & Ambientali, Ist Zootecn, I-29122 Piacenza, Italy.
EM giuseppe.bertoni@unicatt.it
RI Minuti, Andrea/AAF-8663-2021
OI TREVISI, Erminio/0000-0003-1644-1911; Minuti, Andrea/0000-0002-0617-6571
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NR 53
TC 44
Z9 51
U1 4
U2 61
PU CSIRO PUBLISHING
PI CLAYTON
PA UNIPARK, BLDG 1, LEVEL 1, 195 WELLINGTON RD, LOCKED BAG 10, CLAYTON, VIC
   3168, AUSTRALIA
SN 1836-0939
EI 1836-5787
J9 ANIM PROD SCI
JI Anim. Prod. Sci.
PY 2015
VL 55
IS 7
BP 943
EP 948
DI 10.1071/AN14863
PG 6
WC Agriculture, Dairy & Animal Science
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Agriculture
GA CK7DA
UT WOS:000356389700014
DA 2025-06-11
ER

PT J
AU Ekuni, D
   Mizutani, S
   Kojima, A
   Tomofuji, T
   Irie, K
   Azuma, T
   Yoneda, T
   Furuta, M
   Eshima, N
   Iwasaki, Y
   Morita, M
AF Ekuni, Daisuke
   Mizutani, Shinsuke
   Kojima, Azusa
   Tomofuji, Takaaki
   Irie, Koichiro
   Azuma, Tetsuji
   Yoneda, Toshiki
   Furuta, Michiko
   Eshima, Nobuoki
   Iwasaki, Yoshiaki
   Morita, Manabu
TI Relationship between increases in BMI and changes in periodontal status:
   a prospective cohort study
SO JOURNAL OF CLINICAL PERIODONTOLOGY
LA English
DT Article
DE body mass index; cohort studies; obesity; oral health behaviours;
   periodontal disease; university students
ID BODY-MASS INDEX; DISEASE PROGRESSION; METABOLIC SYNDROME; OXIDATIVE
   STRESS; RISK INDICATORS; JAPANESE WOMEN; OBESITY; ASSOCIATION; YOUNG;
   OVERWEIGHT
AB Aim: The purpose of this prospective cohort study was to investigate whether body mass index (BMI) and oral health behaviour are related to changes in periodontal status in Japanese university students.
   Materials and Methods: Students (n = 224) who were interested in receiving oral health examinations before entering university and before graduation were included in the analysis. Subjects were investigated regarding the correlations of oral health behaviours and increases in BMI with the percentage of bleeding on probing (% BOP) and Community Periodontal Index (CPI) scores as indicators of changes in periodontal status.
   Results: The risk of increased % BOP was associated with the non-use of dental floss (adjusted odds ratio [OR]: 3.11; 95% confidence interval [CI]: 1.31-7.37; p < 0.05), whereas the risk of increased CPI score was associated with increases in BMI (OR: 1.95; 95% CI: 1.05-3.65; p < 0.05) and simplified oral hygiene index score (OR: 2.28; 95% CI: 1.23-4.22; p < 0.01).
   Conclusion: Increases in BMI were associated with worsening of periodontal status, defined as increased CPI score in Japanese university students, whereas lack of inter-dental cleaning was associated with exacerbated gingival bleeding.
C1 [Ekuni, Daisuke; Mizutani, Shinsuke; Kojima, Azusa; Tomofuji, Takaaki; Azuma, Tetsuji; Yoneda, Toshiki; Morita, Manabu] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Prevent Dent, Okayama 7008558, Japan.
   [Irie, Koichiro] Aichi Gakuin Univ, Sch Dent, Dept Prevent Dent & Dent Publ Hlth, Nagoya, Aichi 464, Japan.
   [Furuta, Michiko] Kyushu Univ, Sect Prevent & Publ Hlth Dent, Div Oral Hlth Growth & Dev, Fac Dent Sci, Fukuoka 812, Japan.
   [Eshima, Nobuoki] Oita Univ, Fac Med, Dept Biostat, Oita 87011, Japan.
   [Iwasaki, Yoshiaki] Okayama Univ, Hlth Serv Ctr, Okayama 7008530, Japan.
C3 Okayama University; Aichi Gakuin University; Kyushu University; Oita
   University; Okayama University
RP Tomofuji, T (corresponding author), Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Prevent Dent, Kita Ku, 2-5-1 Shikata Cho, Okayama 7008558, Japan.
EM tomofu@md.okayama-u.ac.jp
RI Mizutani, Shinsuke/AAC-7395-2019
OI Mizutani, Shinsuke/0000-0003-1512-1270
FU Grants-in-Aid for Scientific Research [26330045] Funding Source: KAKEN
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NR 45
TC 43
Z9 48
U1 0
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0303-6979
EI 1600-051X
J9 J CLIN PERIODONTOL
JI J. Clin. Periodontol.
PD AUG
PY 2014
VL 41
IS 8
BP 772
EP 778
DI 10.1111/jcpe.12273
PG 7
WC Dentistry, Oral Surgery & Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dentistry, Oral Surgery & Medicine
GA AN4FI
UT WOS:000340542600005
PM 24813869
DA 2025-06-11
ER

PT J
AU Fernandes, R
   Beserra, BTS
   Cunha, RSG
   Hillesheim, E
   Camargo, CD
   Pequito, DCT
   de Castro, IC
   Fernandes, LC
   Nunes, EA
   Trindade, EBSD
AF Fernandes, Ricardo
   Soares Beserra, Bruna Teles
   Granato Cunha, Raphael Salles
   Hillesheim, Elaine
   Camargo, Carolina de Quadros
   Tonello Pequito, Danielle Cristina
   de Castro, Isabela Coelho
   Fernandes, Luiz Claudio
   Nunes, Everson Araujo
   Santos de Moraes Trindade, Erasmo Benicio
TI Relationship between Acute Phase Proteins and Serum Fatty Acid
   Composition in Morbidly Obese Patients
SO DISEASE MARKERS
LA English
DT Article
ID C-REACTIVE PROTEIN; ESTIMATED DESATURASE ACTIVITIES; BARIATRIC SURGERY;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; OXIDATIVE STRESS;
   ADIPOSE-TISSUE; JAPANESE MEN; INFLAMMATION; PLASMA
AB Background. Obesity is considered a low-grade inflammatory state and has been associated with increased acute phase proteins as well as changes in serum fatty acids. Few studies have assessed associations between acute phase proteins and serum fatty acids in morbidly obese patients. Objective. To investigate the relationship between acute phase proteins (C-Reactive Protein, Orosomucoid, and Albumin) and serum fatty acids in morbidly obese patients. Methods. Twenty-two morbidly obese patients were enrolled in this study. Biochemical and clinical data were obtained before bariatric surgery, and fatty acids measured in preoperative serum. Results. Orosomucoid was negatively correlated with lauric acid (P = 0.027) and eicosapentaenoic acid (EPA) (P = 0.037) and positively with arachidonic acid (AA) (P = 0.035), AA/EPA ratio (P = 0.005), and n-6/n-3 polyunsaturated fatty acids ratio (P = 0.035). C-Reactive Protein (CRP) was negatively correlated with lauric acid (P = 0.048), and both CRP and CRP/Albumin ratio were negatively correlated with margaric acid (P = 0.010, P = 0.008, resp.). Albumin was positively correlated with EPA (P = 0.027) and margaric acid (P = 0.008). Other correlations were not statistically significant. Conclusion. Our findings suggest that serum fatty acids are linked to acute phase proteins in morbidly obese patients.
C1 [Fernandes, Ricardo; Soares Beserra, Bruna Teles; Camargo, Carolina de Quadros; Santos de Moraes Trindade, Erasmo Benicio] Univ Fed Santa Catarina, Postgrad Program Nutr, BR-88040900 Florianopolis, SC, Brazil.
   [Granato Cunha, Raphael Salles; Hillesheim, Elaine] Univ Fed Santa Catarina, Grad Program Nutr Ctr, BR-88040900 Florianopolis, SC, Brazil.
   [Tonello Pequito, Danielle Cristina; de Castro, Isabela Coelho; Fernandes, Luiz Claudio] Univ Fed Parana, Dept Physiol, BR-81530900 Jardim Das Americas, PR, Brazil.
   [Nunes, Everson Araujo] Univ Fed Santa Catarina, Ctr Biol Sci, Dept Physiol Sci, BR-88040900 Florianopolis, SC, Brazil.
   [Santos de Moraes Trindade, Erasmo Benicio] Univ Fed Santa Catarina, Dept Nutr, BR-88040900 Florianopolis, SC, Brazil.
C3 Universidade Federal de Santa Catarina (UFSC); Universidade Federal de
   Santa Catarina (UFSC); Universidade Federal do Parana; Universidade
   Federal de Santa Catarina (UFSC); Universidade Federal de Santa Catarina
   (UFSC)
RP Trindade, EBSD (corresponding author), Univ Fed Santa Catarina, Dept Nutr, Trindade Campus, BR-88040900 Florianopolis, SC, Brazil.
EM erasmotrindade@gmail.com
RI Fernandes, Ricardo/X-4974-2019; Fernandes, Luiz/I-4907-2014; Hillesheim,
   Elaine/M-3810-2015; COELHO DE CASTRO, ISABELA/NJS-0309-2025; Camargo,
   Carolina/MHQ-9010-2025; Trindade, Erasmo Benicio Santos de
   Moraes/NKO-7350-2025; Araujo Nunes, Everson/F-7222-2012; Fernandes,
   Ricardo/C-9071-2013
OI Trindade, Erasmo Benicio Santos de Moraes/0000-0003-1736-4049; Araujo
   Nunes, Everson/0000-0001-9994-5677; Fernandes,
   Ricardo/0000-0002-8707-869X; Camargo, Carolina/0000-0003-0966-8384;
   Fernandes, Luiz/0000-0001-9919-0681; Hillesheim,
   Elaine/0000-0002-2138-3181
FU University Hospital of Federal University of Santa Catarina
FX The authors are grateful to the Multidisciplinary Integrated Residency
   Program in Health at the University Hospital of Federal University of
   Santa Catarinaby for the assistance with patients and blood sample
   logistic. This work was supported by the University Hospital of Federal
   University of Santa Catarina.
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NR 57
TC 7
Z9 10
U1 0
U2 7
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 0278-0240
EI 1875-8630
J9 DIS MARKERS
JI Dis. Markers
PY 2013
VL 2013
BP 105
EP 112
DI 10.1155/2013/913715
PG 8
WC Biotechnology & Applied Microbiology; Genetics & Heredity; Medicine,
   Research & Experimental; Pathology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Genetics & Heredity; Research &
   Experimental Medicine; Pathology
GA 212MO
UT WOS:000323987700001
PM 24167354
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Chetty, VT
   Sharma, AA
AF Chetty, Vasudhevan T.
   Sharma, Arya A.
TI Can PPAR-γ agonists have a role in the management of obesity-related
   hypertension?
SO VASCULAR PHARMACOLOGY
LA English
DT Review
DE PPAR gamma; peroxisome proliferator-activated receptor; hypertension;
   obesity
ID PROLIFERATOR-ACTIVATED RECEPTOR; LOWERS BLOOD-PRESSURE; INDEPENDENT
   RISK-FACTOR; NITRIC-OXIDE SYNTHASE; LOW-ENERGY DIET; INSULIN-RESISTANCE;
   SMOOTH-MUSCLE; OXIDATIVE STRESS; LIGAND-BINDING; PIOGLITAZONE
AB Peroxisome proliferator-activated receptors (PPAR) are ligand-activated transcription factors belonging to the nuclear hormone receptor superfamily. PPAR gamma is the most extensively studied amongst the three subtypes (alpha, delta and gamma). This receptor is a key modulator of lipid and glucose horneostasis and is predominantly expressed in adipose tissue. Expression of PPAR gamma is also found in non-adipose tissues including heart, kidney, spleen, and interestingly, in all relevant components of the vasculature: endothelial and smooth muscle cells. These receptors may therefore also play a role in the regulation of vascular tone and blood pressure. Genetic variants of PPAR gamma have also been associated with features of the metabolic syndrome, including obesity and increased blood pressure. The discovery of synthetic ligands for PPAR gamma, the Thiazolidinediones (TZDs) has greatly enhanced our understanding of their ligand dependent activation and more importantly their role in vascular pathobiology. Approximately 10 years ago, serendipitous animal experiments demonstrated that despite causing sodium retention, the TZDs actually lowered blood pressure. This review will highlight the role of TZDs in various models of hypertension and discuss their potential role in the management of obesity-related hypertension. (c) 2006 Published by Elsevier Inc.
C1 McMaster Univ, Michael Groote Sch Med, Hamilton, ON, Canada.
C3 McMaster University
RP Chetty, VT (corresponding author), St Josephs Hosp, L402-3 Core Lab,50 Charlton Ave E, Hamilton, ON L8N 4A8, Canada.
EM chetty@hhsc.ca
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NR 78
TC 24
Z9 29
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1537-1891
EI 1879-3649
J9 VASC PHARMACOL
JI Vasc. Pharmacol.
PD JUL
PY 2006
VL 45
IS 1
SI SI
BP 46
EP 53
DI 10.1016/j.vph.2005.11.010
PG 8
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 064ZZ
UT WOS:000239130500006
PM 16713364
DA 2025-06-11
ER

PT J
AU Fayazi, F
   Kheirouri, S
   Alizadeh, M
AF Fayazi, Fakhrosadat
   Kheirouri, Sorayya
   Alizadeh, Mohammad
TI Exploring effects of melatonin supplementation on insulin resistance: An
   updated systematic review of animal and human studies
SO DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS
LA English
DT Review
DE FPG; HOMA-IR; Insulin; Insulin resistance; Melatonin; QUICKI
ID IMPROVES GLUCOSE-HOMEOSTASIS; METABOLIC SYNDROME; OXIDATIVE STRESS;
   URIC-ACID; ADIPONECTIN; PROTECTS; LEPTIN; ANTIOXIDANT; BLIND; HEART
AB Background: Insulin resistance (IR), defined as an impaired response to insulin stimulation of target tissues, is a substantial determinant of many metabolic disorders. This study aimed to update the findings of the previous systematic review evidence regarding the effect of melatonin on factors related to IR, including hyperinsulinemia, hyperglycemia, homeostasis model assessment of insulin resistance (HOMA-IR), and quantitative insulin sensitivity check index (QUICKI). Methods: We systematically reviewed the evidence on the impact of melatonin supplementation on IR indices, fasting insulin, and fasting plasma glucose. PubMed, ScienceDirect, SCOPUS, and Google Scholar databases were searched until March 2024. Results: We identified 6114 potentially relevant articles during the search. Eighteen animal studies and 15 randomized clinical trials met the inclusion criteria. The results indicated that melatonin supplementation reduced fasting plasma glucose (FPG, 14 out of 29 studies), fasting insulin (22 out of 28 studies), HOMA-IR (28 out of 33 studies), and increased QUICKI (7 out of 7 studies). According to RCT studies, melatonin treatment at a dosage of 10 mg reduced HOMA-IR levels in individuals with various health conditions. Conclusion: According to most evidence, melatonin supplementation may decrease fasting insulin and HOMA-IR and increase QUICKI but may not affect FPG.
C1 [Fayazi, Fakhrosadat] Tabriz Univ Med Sci, Student Res Ctr, Tabriz, Iran.
   [Kheirouri, Sorayya; Alizadeh, Mohammad] Tabriz Univ Med Sci, Fac Nutr & Food Sci, Dept Nutr, Attar Nishabouri St,POB 14711, Tabriz 5166614711, Iran.
   [Alizadeh, Mohammad] Tabriz Univ Med Sci, Nutr Res Ctr, Tabriz, Iran.
C3 Tabriz University of Medical Science; Tabriz University of Medical
   Science; Tabriz University of Medical Science
RP Kheirouri, S; Alizadeh, M (corresponding author), Tabriz Univ Med Sci, Fac Nutr & Food Sci, Dept Nutr, Attar Nishabouri St,POB 14711, Tabriz 5166614711, Iran.
EM fna_fayazi@yahoo.com; kheirouris@tbzmed.ac.ir; mdalizadeh@tbzmed.ac.ir
RI Alizadeh, Mohammad/M-4703-2017
FU Vice chancellor for Research and Student Research Committee of Tabriz
   University of Medical Sciences, Tabriz, Iran [65798]
FX The current article is based on data for MSc thesis on nutrition and
   funded by the Vice chancellor for Research and Student Research
   Committee of Tabriz University of Medical Sciences, Tabriz, Iran (grant
   number:65798).
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NR 71
TC 4
Z9 4
U1 2
U2 3
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 1871-4021
EI 1878-0334
J9 DIAB MET SYND CLIN R
JI DIABET. METAB. SYNDR. CLIN. RES. REV.
PD JUL
PY 2024
VL 18
IS 7
AR 103073
DI 10.1016/j.dsx.2024.103073
EA AUG 2024
PG 8
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA C2P3P
UT WOS:001287822900001
PM 39096757
DA 2025-06-11
ER

PT J
AU Zhang, YZ
   Li, YQ
   Xia, Q
   Liu, LL
   Wu, ZF
   Pan, DD
AF Zhang, Yunzhen
   Li, Yueqin
   Xia, Qiang
   Liu, Lianliang
   Wu, Zufang
   Pan, Daodong
TI Recent advances of cereal β-glucan on immunity with gut microbiota
   regulation functions and its intelligent gelling application
SO CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
LA English
DT Review
DE Cereal beta-glucan; gelling properties; gut immunity; intelligent food
   packaging; prebiotic effects
ID HULL-LESS BARLEY; INTESTINAL EPITHELIAL-CELLS; SOLUBLE DIETARY-FIBERS;
   BILE-ACID BINDING; WHOLE-GRAIN OAT; IN-VITRO; MOLECULAR-WEIGHT;
   RHEOLOGICAL PROPERTIES; PHYSICOCHEMICAL PROPERTIES;
   CHOLESTEROL-METABOLISM
AB beta-glucan from cereals such as wheat, barley, oats and rye are a water-soluble dietary fiber, which are composed of repeating (1 -> 4)-beta-bond beta-D-glucopyranosyl units and a single (1 -> 3)-beta-D-bond separated unit. beta-glucan has a series of physicochemical properties (such as viscosity, gelling properties, solubility, etc.), which can be used as a food gel and fat substitute. Its structure endows the healthy functions, including anti-oxidative stress, lowering blood glucose and serum cholesterol, regulating metabolic syndrome and exerting gut immunity via gut microbiota. Due to their unique structural properties and efficacy, cereal beta-glucan are not only applied in food substrates in the food industry, but also in food coatings and packaging. This article reviewed the applications of cereal beta-glucan in hydrogels, aerogels, intelligent packaging systems and targeted delivery carriers in recent years. Cereal beta-glucan in edible film and gel packaging applications are becoming more diversified and intelligent in recent years. Those advances provide a potential solution based on cereal beta-glucan as biodegradable substances for immune regulation delivery system and intelligent gelling material in the biomedicine field.
C1 [Zhang, Yunzhen; Li, Yueqin; Xia, Qiang; Liu, Lianliang; Wu, Zufang; Pan, Daodong] Ningbo Univ, Coll Food & Pharmaceut Sci, Deep Proc Technol Key Lab Zhejiang Prov Anim Prot, Ningbo, Zhejiang, Peoples R China.
C3 Ningbo University
RP Liu, LL (corresponding author), Ningbo Univ, Coll Food & Pharmaceut Sci, Deep Proc Technol Key Lab Zhejiang Prov Anim Prot, Ningbo, Zhejiang, Peoples R China.
EM lianliang626@hotmail.com
RI Liu, Lianliang/AGN-3565-2022; XIA, QIANG/AAJ-2055-2021
OI Zhang, Yunzhen/0009-0001-4712-6044
FU National Natural Science Foundation of China [31601476]; Zhejiang
   Provincial Natural Science Foundation [LY21C200005]; Natural Science
   Foundation of Ningbo [2019A610439]; Ningbo Public Welfare Science and
   Technology Projects [202002N3080]
FX The work was supported by National Natural Science Foundation of China
   (31601476), Zhejiang Provincial Natural Science Foundation
   (LY21C200005), Natural Science Foundation of Ningbo (2019A610439),
   Ningbo Public Welfare Science and Technology Projects (202002N3080).
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NR 164
TC 41
Z9 41
U1 17
U2 284
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1040-8398
EI 1549-7852
J9 CRIT REV FOOD SCI
JI Crit. Rev. Food Sci. Nutr.
PD JUL 26
PY 2023
VL 63
IS 19
BP 3895
EP 3911
DI 10.1080/10408398.2021.1995842
EA OCT 2021
PG 17
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA M1MH2
UT WOS:000715680000001
PM 34748438
DA 2025-06-11
ER

PT J
AU Chang, S
   Skakkebaek, A
   Davis, SM
   Gravholt, CH
AF Chang, Simon
   Skakkebaek, Anne
   Davis, Shanlee M.
   Gravholt, Claus H.
TI Morbidity in Klinefelter syndrome and the effect of testosterone
   treatment
SO AMERICAN JOURNAL OF MEDICAL GENETICS PART C-SEMINARS IN MEDICAL GENETICS
LA English
DT Review
DE hypogonadism; Klinefelter syndrome; review article; testosterone
   treatment
ID BONE-MINERAL DENSITY; QUALITY-OF-LIFE; METABOLIC SYNDROME; 47,XYY
   SYNDROME; BOYS; MEN; REPLACEMENT; ADOLESCENTS; THERAPY; RISK
AB Klinefelter syndrome (KS; 47,XXY) is the most common sex chromosome abnormality in males (150 per 100,000 males). The condition leads to hypergonadotropic hypogonadism and ever since the condition was described approximately 80 years ago, testosterone treatment has been the cornerstone in care for individuals with KS. However, KS is associated with an array of health-related and socioeconomic challenges and it is becoming progressively clear that proper care for boys and men with KS reaches far beyond simply supplementing with testosterone. There are no widely implemented guidelines for KS care, and studies investigating crucial aspects of testosterone treatment in individuals with KS, including both beneficial and potentially adverse effects, have only begun to emerge during the last decades. For this descriptive review, we present an overview of literature describing health-related outcomes of testosterone treatment in KS and outline the clinical applications of testosterone treatment in KS. Collectively, beneficial effects of testosterone treatment on overall health in KS are described with few apparent adverse effects. However, larger randomized studies in adult and pediatric patients are warranted to elucidate key aspects of treatment. We stress the implementation of centralized multidisciplinary clinics and the need for a dedicated international guideline to ensure optimal care of boys and men with KS.
C1 [Chang, Simon; Gravholt, Claus H.] Aarhus Univ Hosp, Dept Endocrinol & Internal Med, Aarhus, Denmark.
   [Chang, Simon] Lillebaelt Hosp, Dept Internal Med, Sygehusvej 24, DK-6000 Kolding, Denmark.
   [Chang, Simon] Hosp South West Jutland, Unit Thrombosis Res, Esbjerg, Denmark.
   [Skakkebaek, Anne] Aarhus Univ Hosp, Dept Clin Genet, Aarhus, Denmark.
   [Skakkebaek, Anne; Gravholt, Claus H.] Aarhus Univ Hosp, Dept Mol Med, Aarhus, Denmark.
   [Davis, Shanlee M.] Univ Colorado, Dept Pediat, Sch Med, Aurora, CO USA.
   [Davis, Shanlee M.] Childrens Hosp Colorado, eXtraordinarY Kids Clin & Res Program, Aurora, CO USA.
C3 Aarhus University; Aarhus University; Aarhus University; University of
   Colorado System; University of Colorado Anschutz Medical Campus;
   Children's Hospital Colorado
RP Chang, S (corresponding author), Lillebaelt Hosp, Dept Internal Med, Sygehusvej 24, DK-6000 Kolding, Denmark.
EM simon.chang@rsyd.dk
RI Skakkebæk, Anne/P-2345-2015; Chang, Simon/I-8476-2012; Davis,
   Shanlee/AGK-1133-2022; Gravholt, Claus/Z-1435-2018
OI Skakkebaek, Anne/0000-0001-9178-4901; Gravholt,
   Claus/0000-0001-5924-1720; Davis, Shanlee/0000-0002-0304-9550; Chang,
   Simon/0000-0003-1130-3659
FU Familien Hede Nielsens Fond; NIH/NIDDK [K23HD092588]; Novo Nordisk
   Fonden [NNF13OC0003234, NNF15OC0016474]
FX Familien Hede Nielsens Fond, Grant/Award Number: N/A; NIH/NIDDK,
   Grant/Award Number: K23HD092588; Novo Nordisk Fonden, Grant/Award
   Numbers: NNF13OC0003234, NNF15OC0016474
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NR 73
TC 18
Z9 18
U1 1
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1552-4868
EI 1552-4876
J9 AM J MED GENET C
JI Am. J. Med. Genet. C
PD JUN
PY 2020
VL 184
IS 2
SI SI
BP 344
EP 355
DI 10.1002/ajmg.c.31798
EA JUN 2020
PG 12
WC Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Genetics & Heredity
GA MC1OF
UT WOS:000537532200001
PM 32496001
OA Green Accepted, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Tsai, SW
   Huang, CC
   Hsu, YJ
   Chen, CJ
   Lee, PY
   Huang, YH
   Lee, MC
   Chiu, YS
   Tung, YT
AF Tsai, Sen-Wei
   Huang, Chi-Chang
   Hsu, Yi-Ju
   Chen, Chun-Jung
   Lee, Po-Ying
   Huang, Yu-Hui
   Lee, Mon-Chien
   Chiu, Yen-Shuo
   Tung, Yu-Tang
TI Accelerated Muscle Recovery After In Vivo Curcumin Supplementation
SO NATURAL PRODUCT COMMUNICATIONS
LA English
DT Article
DE curcumin; contusion; mass-drop injury; diclofenac
ID QUALITY-OF-LIFE; NF-KAPPA-B; CHRONIC PULMONARY COMPLICATIONS; RANDOMIZED
   CONTROLLED-TRIAL; SULFUR MUSTARD; DOUBLE-BLIND; PIPERINE COMBINATION;
   METABOLIC SYNDROME; OXIDATIVE STRESS; NULL MUTATION
AB The currently available treatment options for muscle injuries are suboptimal and often delay muscle recovery. In this study, the effects of curcumin on inflammation and skeletal muscle regeneration after contusion-induced injury in mice were investigated. The mice were randomly assigned to 4 groups, namely normal control (NC), with induced injury (mass-drop injury, MDI) and without treatment (MDI [M]), with induced injury and diclofenac (DCF) treatment (MDI + DCF [M + D]), and with induced injury and curcumin treatment (MDI + curcumin [M + C]). Contusion-induced injury was inflicted on the left gastrocnemius muscle, and DCF or curcumin was orally administered after injury once per day for 7 days. The M group exhibited significantly higher lipid peroxidation, myeloperoxidase (MPO), and desmin than the NC group. The M + D and M + C groups have lower lipid peroxidation and neutrophils (decrease in MPO protein) and higher muscle satellite cell regeneration (increase in desmin protein) than the M group. Additionally, for the contusion-induced muscle injury, curcumin could affect the specific proteins of inflammation, neutrophils, and differentiation of satellite cells, including Ikk-alpha/beta, MPO, and myogenin. In conclusion, curcumin potentially accelerates muscle recovery; therefore, it may be a potential candidate for further research as an effective treatment to enhance muscle repair.
C1 [Tsai, Sen-Wei] Buddhist Tzu Chi Med Fdn, Dept Phys Med & Rehabil, Taichung Tzu Chi Hosp, Taichung, Taiwan.
   [Tsai, Sen-Wei] Tzu Chi Univ, Sch Med, Dept Phys Med & Rehabil, Hualien, Taiwan.
   [Huang, Chi-Chang; Hsu, Yi-Ju; Lee, Mon-Chien] Natl Taiwan Sport Univ, Grad Inst Sports Sci, Taoyuan, Taiwan.
   [Huang, Chi-Chang; Tung, Yu-Tang] Taipei Med Univ, Grad Inst Metab & Obes Sci, Taipei 11031, Taiwan.
   [Chen, Chun-Jung] Taichung Vet Gen Hosp, Dept Med & Res, Taichung, Taiwan.
   [Lee, Po-Ying] Cathay Gen Hosp, Div Plast Surg, Dept Surg, Taipei, Taiwan.
   [Huang, Yu-Hui] Chung Shan Med Univ Hosp, Dept Phys Med & Rehabil, Taichung, Taiwan.
   [Huang, Yu-Hui] Chung Shan Med Univ, Sch Med, Taichung, Taiwan.
   [Huang, Yu-Hui] Chung Shan Med Univ, Sch Phys Therapy, Taichung, Taiwan.
   [Chiu, Yen-Shuo] Taipei Med Univ, Shuang Ho Hosp, Dept Orthoped Surg, New Taipei, Taiwan.
   [Tung, Yu-Tang] Taipei Med Univ Hosp, Nutr Res Ctr, Taipei, Taiwan.
   [Tung, Yu-Tang] Taipei Med Univ, Wan Fang Hosp, Cell Physiol & Mol Image Res Ctr, Taipei, Taiwan.
C3 Buddhist Tzu Chi General Hospital; Taichung Tzu Chi Hospital; Tzu Chi
   University; National Taiwan Sport University; Taipei Medical University;
   Taichung Veterans General Hospital; Cathay General Hospital; Chung Shan
   Medical University; Chung Shan Medical University Hospital; Chung Shan
   Medical University; Chung Shan Medical University; Taipei Medical
   University; Shuang Ho Hospital; Taipei Medical University; Taipei
   Medical University Hospital; Taipei Municipal WanFang Hospital; Taipei
   Medical University
RP Tung, YT (corresponding author), Taipei Med Univ, Grad Inst Metab & Obes Sci, Taipei 11031, Taiwan.
EM f91625059@tmu.edu.tw
RI chen, changhan/K-6713-2018; Huang, Chi-Chang/A-3280-2013; Huang,
   Yuhui/KQV-2980-2024
OI Tung, Yu-Tang/0000-0002-4780-6496
FU Taichung Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation
   [TTCRD105-03]; Ministry of Science and Technology of Taiwan [MOST
   105-2314-B-303-004]
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: This
   research was supported by an institutional grant to Dr Tsai (grant No.
   TTCRD105-03 from Taichung Tzu Chi Hospital, Buddhist Tzu Chi Medical
   Foundation), and partly supported by the Ministry of Science and
   Technology of Taiwan (grant No. MOST 105-2314-B-303-004 to Dr Tsai).
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NR 57
TC 10
Z9 10
U1 2
U2 8
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1934-578X
EI 1555-9475
J9 NAT PROD COMMUN
JI Nat. Prod. Commun.
PD JAN
PY 2020
VL 15
IS 1
DI 10.1177/1934578X20901898
PG 9
WC Chemistry, Medicinal; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Food Science & Technology
GA KE5HV
UT WOS:000508587500001
OA gold
DA 2025-06-11
ER

PT J
AU Viana-Huete, V
   Guillén, C
   García, G
   Fernández, S
   García-Aguilar, A
   Kahn, CR
   Benito, M
AF Viana-Huete, Vanesa
   Guillen, Carlos
   Garcia, Gema
   Fernandez, Silvia
   Garcia-Aguilar, Ana
   Kahn, C. R.
   Benito, Manuel
TI Male Brown Fat-Specific Double Knockout of IGFIR/IR: Atrophy,
   Mitochondrial Fission Failure, Impaired Thermogenesis, and Obesity
SO ENDOCRINOLOGY
LA English
DT Article
ID ADIPOSE-TISSUE; ENERGY-EXPENDITURE; INSULIN-RESISTANCE; IGF-1 RECEPTORS;
   ADIPOCYTES; PROTEIN; DYNAMICS; ABLATION; HORMONE; STRESS
AB It is unknown how the lack of insulin receptor (IR)/insulinlike growth factor I receptor (IGFIR) in a tissue-specific manner affects brown fat development and mitochondrial integrity and function, as well as its effect on the redistribution of the adipose organ and the metabolic status. To address this important issue, we developed IR/IGFIR double-knockout (DKO) in a brown adipose tissue-specific manner. Lack of those receptors caused severe brown fat atrophy, enhanced beige cell clusters in inguinal fat; loss of mitochondrial mass; mitochondrial damage related to cristae disruption; and the loss of proteins involved in autophagosome formation, mitophagy, mitochondrial quality control, and dynamics and thermogenesis. More important, DKO mice showed an impaired thermogenesis upon cold exposure, based on a failure in the mitochondrial fission mechanisms and a much lower uncoupling protein 1 transcription rate and content. As a result, DKO mice under normal conditions showed an obesity susceptibility, revealed by increased body fat mass and insulin resistance. Upon consumption of a high-fat diet, DKO mice displayed frank obesity, as shown by increased body weight, increased adiposity, insulin resistance, hyperinsulinemia, and hypertriglyceridemia, all consistent with a metabolic syndrome. Collectively, our data suggest a cause-and-effect relationship between failure in brown fat thermogenesis and increased adiposity and obesity.
C1 [Viana-Huete, Vanesa; Guillen, Carlos; Garcia, Gema; Fernandez, Silvia; Garcia-Aguilar, Ana; Benito, Manuel] Univ Complutense Madrid, Fac Pharm, Dept Biochem & Mol Biol, Madrid 28040, Spain.
   [Viana-Huete, Vanesa; Guillen, Carlos; Garcia, Gema; Fernandez, Silvia; Benito, Manuel] Inst Hlth Carlos III, Spanish Diabet & Associated Metab Dis Res Ctr, Madrid 28029, Spain.
   [Kahn, C. R.] Harvard Med Sch, Joslin Diabet Ctr, Boston, MA 02215 USA.
C3 Complutense University of Madrid; Harvard University; Harvard University
   Medical Affiliates; Joslin Diabetes Center, Inc.; Harvard Medical School
RP Benito, M (corresponding author), Univ Complutense Madrid, Sch Pharm, Biochem & Mol Biol Dept, Madrid 28040, Spain.
EM mbenito@ucm.es
RI VIANA, VANESA/HKN-2925-2023; Benito, Melissa/IAP-0513-2023; Kahn,
   Ronald/AAY-2435-2021; García-Aguilar, Ana/X-8789-2019; Guillen,
   Carlos/J-9728-2014; Garcia-Aguilar, Ana/A-5172-2017
OI VIANA HUETE, VANESA/0000-0001-8390-1346; Guillen,
   Carlos/0000-0002-9370-6314; Garcia-Aguilar, Ana/0000-0003-1648-7143;
   Guillen, Carlos/0000-0003-2717-1929
FU Ministerio de Economia e Innovacion [SAF2011/22555, SAF2014-51795-R];
   CIBER de Diabetes y Enfermedades Metabolicas Asociadas, Institution de
   Salud Carlos III, Spain
FX Grants SAF2011/22555 and SAF2014-51795-R (to M.B.) from the Ministerio
   de Economia e Innovacion, and CIBER de Diabetes y Enfermedades
   Metabolicas Asociadas, Institution de Salud Carlos III, Spain supported
   this work.
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NR 37
TC 10
Z9 10
U1 0
U2 9
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0013-7227
EI 1945-7170
J9 ENDOCRINOLOGY
JI Endocrinology
PD JAN
PY 2018
VL 159
IS 1
BP 323
EP 340
DI 10.1210/en.2017-00738
PG 18
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA FS3QM
UT WOS:000419697300027
PM 29040448
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Dali-Youcef, N
   Hnia, K
   Blaise, S
   Messaddeq, N
   Blanc, S
   Postic, C
   Valet, P
   Tomasetto, C
   Rio, MC
AF Dali-Youcef, Nassim
   Hnia, Karim
   Blaise, Sebastien
   Messaddeq, Nadia
   Blanc, Stephane
   Postic, Catherine
   Valet, Philippe
   Tomasetto, Catherine
   Rio, Marie-Christine
TI Matrix metalloproteinase 11 protects from diabesity and promotes
   metabolic switch
SO SCIENTIFIC REPORTS
LA English
DT Article
ID NEGATIVE REGULATOR; CANCER-CELLS; STROMELYSIN-3; ENERGY; FAT;
   ADIPOGENESIS; ADIPOCYTES; RECEPTOR; MMP-2; DEFICIENCY
AB MMP11 overexpression is a bad prognostic factor in various human carcinomas. Interestingly, this proteinase is not expressed in malignant cells themselves but is secreted by adjacent non-malignant mesenchymal/stromal cells, such as cancer associated fibroblasts (CAFs) and adipocytes (CAAs), which favors cancer cell survival and progression. As MMP11 negatively regulates adipogenesis in vitro, we hypothesized that it may play a role in whole body metabolism and energy homeostasis. We used an in vivo gain- (Mmp11-Tg mice) and loss- (Mmp11-/- mice) of-function approach to address the systemic function of MMP11. Strikingly, MMP11 overexpression protects against type 2 diabetes while Mmp11-/- mice exhibit hallmarks of metabolic syndrome. Moreover, Mmp11-Tg mice were protected from diet-induced obesity and display mitochondrial dysfunction, due to oxidative stress, and metabolic switch from oxidative phosphorylation to aerobic glycolysis. This Warburg-like effect observed in adipose tissues might provide a rationale for the deleterious impact of CAA-secreted MMP11, favouring tumor progression. MMP11 overexpression also leads to increased circulating IGF1 levels and the activation of the IGF1/AKT/FOXO1 cascade, an important metabolic signalling pathway. Our data reveal a major role for MMP11 in controlling energy metabolism, and provide new clues for understanding the relationship between metabolism, cancer progression and patient outcome.
C1 [Dali-Youcef, Nassim; Blaise, Sebastien; Tomasetto, Catherine; Rio, Marie-Christine] Univ Strasbourg, Dept Funct Genom & Canc, IGBMC, CNRS,UMR 7104,INSERM,U964, 1 Rue Laurent Fries, F-67404 Illkirch Graffenstaden, France.
   [Dali-Youcef, Nassim] Hop Univ Strasbourg, Pole Biol, Lab Biochim & Biol Mol, 1 Pl Hop, F-67098 Strasbourg, France.
   [Hnia, Karim] Univ Strasbourg, Dept Translat Med & Neurogenet, IGBMC, CNRS,UMR 7104,INSERM,U964, 1 Rue Laurent Fries, F-67404 Illkirch Graffenstaden, France.
   [Hnia, Karim; Valet, Philippe] Univ Toulouse, UPS, Inst Malad Metab & Cardiovasc, INSERM,U1048, Toulouse, France.
   [Messaddeq, Nadia] Univ Strasbourg, Electron Microscopy Platform, IGBMC, CNRS,UMR 7104,INSERM,U964, 1 Rue Laurent Fries, F-67404 Illkirch Graffenstaden, France.
   [Blanc, Stephane] Univ Strasbourg, Inst Pluridisciplinaire Hubert Curien, CNRS, UMR 7178,IN2P3,INC,INEE, 23 Rue Loess BP28, F-67037 Strasbourg 2, France.
   [Postic, Catherine] Univ Paris 05, Sorbonne Paris Cite, INSERM, U1016,Inst Cochin,CNRS,UMR8104, F-75014 Paris, France.
   [Blaise, Sebastien] Univ Reims, CNRS, UMR 7369, Unite MEDyC, Reims, France.
C3 Centre National de la Recherche Scientifique (CNRS); CNRS - National
   Institute for Biology (INSB); Institut National de la Sante et de la
   Recherche Medicale (Inserm); Universites de Strasbourg Etablissements
   Associes; Universite de Strasbourg; Universites de Strasbourg
   Etablissements Associes; Universite de Strasbourg; CHU Strasbourg;
   Institut National de la Sante et de la Recherche Medicale (Inserm);
   Centre National de la Recherche Scientifique (CNRS); CNRS - National
   Institute for Biology (INSB); Universites de Strasbourg Etablissements
   Associes; Universite de Strasbourg; Universite de Toulouse; Universite
   Toulouse III - Paul Sabatier; Institut National de la Sante et de la
   Recherche Medicale (Inserm); Universites de Strasbourg Etablissements
   Associes; Universite de Strasbourg; Institut National de la Sante et de
   la Recherche Medicale (Inserm); Centre National de la Recherche
   Scientifique (CNRS); CNRS - National Institute for Biology (INSB);
   Universites de Strasbourg Etablissements Associes; Universite de
   Strasbourg; Centre National de la Recherche Scientifique (CNRS); CNRS -
   Institute of Chemistry (INC); CNRS - National Institute of Nuclear and
   Particle Physics (IN2P3); CNRS - Institute of Ecology & Environment
   (INEE); Universite Paris Cite; Centre National de la Recherche
   Scientifique (CNRS); CNRS - National Institute for Biology (INSB);
   Institut National de la Sante et de la Recherche Medicale (Inserm);
   Centre National de la Recherche Scientifique (CNRS); CNRS - National
   Institute for Biology (INSB); Universite de Reims Champagne-Ardenne
RP Dali-Youcef, N; Rio, MC (corresponding author), Univ Strasbourg, Dept Funct Genom & Canc, IGBMC, CNRS,UMR 7104,INSERM,U964, 1 Rue Laurent Fries, F-67404 Illkirch Graffenstaden, France.; Dali-Youcef, N (corresponding author), Hop Univ Strasbourg, Pole Biol, Lab Biochim & Biol Mol, 1 Pl Hop, F-67098 Strasbourg, France.
EM dali@igbmc.fr; rio@igbmc.fr
RI Blanc, Stéphane/F-5873-2011; Hnia, Karim/ACM-3504-2022; BLAISE,
   Sebastien/AAS-1022-2020; Valet, Philippe/N-7472-2017; Postic,
   Catherine/P-2271-2017; DALI-YOUCEF, Nassim/O-2549-2016; Tomasetto,
   Catherine/J-2783-2014
OI Valet, Philippe/0000-0001-6520-7393; Postic,
   Catherine/0000-0002-1875-6960; BLAISE, Sebastien/0000-0003-3012-1500;
   HNIA, karim/0000-0001-5298-3000; DALI-YOUCEF,
   Nassim/0000-0001-6958-1331; Tomasetto, Catherine/0000-0002-1811-5848
FU Institut National de la Sante et de la Recherche Medicale; Centre
   National de la Recherche Scientifique; Association pour la Recherche sur
   le Cancer; Ligue Nationale Francaise contre le Cancer; LNCC fellowships;
   Institut National du Cancer (ADIPO-K project)
FX We thank greatly Dr. F. Alpy from our laboratory for critical reading of
   the manuscript. We thank also Dr. M.-F. Champy at the Institut Clinique
   de la Souris (ICS) for her help with clinical biochemistry analyses, and
   A. Zahariev and J.-L. Weickert for technical assistance. We thank the
   histology core facility at the ICS for technical assistance. We thank Dr
   S. Chan from IGBMC for her help with the editing process. Dr M.C. Rio
   and Dr. N. Dali-Youcef are the guarantors of this study. This work was
   supported by funds from the Institut National de la Sante et de la
   Recherche Medicale, the Centre National de la Recherche Scientifique,
   the Association pour la Recherche sur le Cancer, the Institut National
   du Cancer (ADIPO-K project), and the Ligue Nationale Francaise contre le
   Cancer (Equipe labellisee; Comites du Haut-Rhin, du Bas-Rhin et de
   Haute-Savoie). S.B. was a recipient of LNCC fellowships.
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NR 49
TC 27
Z9 30
U1 0
U2 12
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD APR 29
PY 2016
VL 6
AR 25140
DI 10.1038/srep25140
PG 12
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA DK8MM
UT WOS:000375180900001
PM 27126782
OA Green Submitted, gold, Green Published
DA 2025-06-11
ER

PT J
AU Oikawa, M
   Owada, T
   Yamauchi, H
   Misaka, T
   Machii, H
   Yamaki, T
   Sugimoto, K
   Kunii, H
   Nakazato, K
   Suzuki, H
   Saitoh, S
   Takeishi, Y
AF Oikawa, Masayoshi
   Owada, Takashi
   Yamauchi, Hiroyuki
   Misaka, Tomofumi
   Machii, Hirofumi
   Yamaki, Takayoshi
   Sugimoto, Koichi
   Kunii, Hiroyuki
   Nakazato, Kazuhiko
   Suzuki, Hitoshi
   Saitoh, Shu-ichi
   Takeishi, Yasuchika
TI Predominance of Abdominal Visceral Adipose Tissue Reflects the Presence
   of Aortic Valve Calcification
SO BIOMED RESEARCH INTERNATIONAL
LA English
DT Article
ID INCREASED OXIDATIVE STRESS; METABOLIC SYNDROME; STENOSIS;
   ATHEROSCLEROSIS; PROGRESSION; SCLEROSIS; OBESITY; DISEASE; HEART
AB Background. Aortic valve calcification (AVC) is a common feature of aging and is related to coronary artery disease. Although abdominal visceral adipose tissue (VAT) plays fundamental roles in coronary artery disease, the relationship between abdominal VAT and AVC is not fully understood. Methods. We investigated 259 patients who underwent cardiac and abdominal computed tomography (CT). AVC was defined as calcified lesion on the aortic valve by CT. % abdominal VAT was calculated as abdominal VAT area/total adipose tissue area. Results. AVC was detected in 75 patients, and these patients showed higher % abdominal VAT (44% versus 38%, p < 0.05) compared to those without AVC. When the cutoff value of % abdominal VAT was set at 40.9%, the area under the curve to diagnose AVC was 0.626. Multivariable logistic regression analysis showed that age (OR 1.120, 95% CI 1.078-1.168, p < 0.01), diabetes (OR 2.587, 95% CI 1.323-5.130, p < 0.01), and % abdominal VAT (OR 1.032, 95% CI 1.003-1.065, p < 0.05) were independent risk factors for AVC. The net reclassification improvement value for detecting AVC was increased when % abdominal VAT was added to the model: 0.5093 (95% CI 0.2489-0.7697, p < 0.01). Conclusion. We determined that predominance of VAT is associated with AVC.
C1 [Oikawa, Masayoshi; Owada, Takashi; Yamauchi, Hiroyuki; Misaka, Tomofumi; Machii, Hirofumi; Yamaki, Takayoshi; Sugimoto, Koichi; Kunii, Hiroyuki; Nakazato, Kazuhiko; Suzuki, Hitoshi; Saitoh, Shu-ichi; Takeishi, Yasuchika] Fukushima Med Univ, Dept Cardiol & Hematol, 1 Hikarigaoka, Fukushima 9601295, Japan.
C3 Fukushima Medical University
RP Oikawa, M (corresponding author), Fukushima Med Univ, Dept Cardiol & Hematol, 1 Hikarigaoka, Fukushima 9601295, Japan.
EM moikawa@fmu.ac.jp
FU Grants-in-Aid for Scientific Research [15K09143] Funding Source: KAKEN
CR Coffey S, 2014, J AM COLL CARDIOL, V63, P2852, DOI 10.1016/j.jacc.2014.04.018
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NR 18
TC 10
Z9 10
U1 0
U2 1
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2314-6133
EI 2314-6141
J9 BIOMED RES INT
JI Biomed Res. Int.
PY 2016
VL 2016
AR 2174657
DI 10.1155/2016/2174657
PG 5
WC Biotechnology & Applied Microbiology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Research & Experimental Medicine
GA DD0ZH
UT WOS:000369649900001
PM 26904670
OA gold, Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Kälin, S
   Heppner, FL
   Bechmann, I
   Prinz, M
   Tschöp, MH
   Yi, CX
AF Kaelin, Stefanie
   Heppner, Frank L.
   Bechmann, Ingo
   Prinz, Marco
   Tschoep, Matthias H.
   Yi, Chun-Xia
TI Hypothalamic innate immune reaction in obesity
SO NATURE REVIEWS ENDOCRINOLOGY
LA English
DT Review
ID NF-KAPPA-B; HIGH-FAT-DIET; GLUCOSE-TRANSPORTER PROTEINS; INDUCED
   INSULIN-RESISTANCE; ARCUATE NUCLEUS; ER STRESS; ALTERNATIVE ACTIVATION;
   MICROGLIAL ACTIVATION; SIGNALING PATHWAYS; NEURONAL CIRCUITS
AB Findings from rodent and human studies show that the presence of inflammatory factors is positively correlated with obesity and the metabolic syndrome. Obesity-associated inflammatory responses take place not only in the periphery but also in the brain. The hypothalamus contains a range of resident glial cells including microglia, macrophages and astrocytes, which are embedded in highly heterogenic groups of neurons that control metabolic homeostasis. This complex neural-glia network can receive information directly from blood-borne factors, positioning it as a metabolic sensor. Following hypercaloric challenge, mediobasal hypothalamic microglia and astrocytes enter a reactive state, which persists during diet-induced obesity. In established mouse models of diet-induced obesity, the hypothalamic vasculature displays angiogenic alterations. Moreover, proopiomelanocortin neurons, which regulate food intake and energy expenditure, are impaired in the arcuate nucleus, where there is an increase in local inflammatory signals. The sum total of these events is a hypothalamic innate immune reactivity, which includes temporal and spatial changes to each cell population. Although the exact role of each participant of the neural-glial-vascular network is still under exploration, therapeutic targets for treating obesity should probably be linked to individual cell types and their specific signalling pathways to address each dysfunction with cell-selective compounds.
C1 [Kaelin, Stefanie; Tschoep, Matthias H.] Helmholtz Ctr Hlth & Environm, Inst Diabet & Obes, D-85748 Munich, Germany.
   [Kaelin, Stefanie; Tschoep, Matthias H.] Tech Univ Munich, D-85748 Munich, Germany.
   [Heppner, Frank L.] Charite, Dept Neuropathol, D-10117 Berlin, Germany.
   [Bechmann, Ingo] Univ Leipzig, Inst Anat, D-04103 Leipzig, Germany.
   [Prinz, Marco] Univ Freiburg, Inst Neuropathol, D-79106 Freiburg, Germany.
   [Yi, Chun-Xia] Univ Amsterdam, Acad Med Ctr, Dept Endocrinol & Metab, NL-1105 AZ Amsterdam, Netherlands.
C3 Technical University of Munich; Berlin Institute of Health; Free
   University of Berlin; Humboldt University of Berlin; Charite
   Universitatsmedizin Berlin; Leipzig University; University of Freiburg;
   University of Amsterdam; Academic Medical Center Amsterdam
RP Tschöp, MH (corresponding author), Helmholtz Ctr Hlth & Environm, Inst Diabet & Obes, D-85748 Munich, Germany.
EM matthias.tschoep@helmholtz-muenchen.de
RI Tschoep, Matthias/I-5443-2014; Prinz, Marco/N-9746-2013; Heppner,
   Frank/ABH-8393-2020; Yi, Chun-Xia/J-4068-2016
OI Yi, Chun-Xia/0000-0003-1184-4615; Heppner, Frank/0000-0001-9816-8917;
   Tschoep, Matthias/0000-0002-4744-371X
FU Deutsche Forschungsgemeinschaft [SFB TRR 43, NeuroCure Exc 257, HE
   3130/6-1]; Federal Ministry of Education and Research (DLR/BMBF;
   Kompetenznetz Degenerative Demenzen); Berlin Institute of Health (BIH);
   Deutsche Forschungsgemeinsschaft [FOR 1336, SFB 1052]; ICEMED; DZD;
   Alexander von Humboldt Foundation; Deutsches Zentrum fur
   Diabetesforschung (DZD); Helmholtz Alliance ICEMED-Imaging and Curing
   Environmental Metabolic Diseases, through the Initiative and Networking
   Fund of the Helmholtz Association
FX F.L.H. is supported by grants from the Deutsche Forschungsgemeinschaft
   (SFB TRR 43, NeuroCure Exc 257 and HE 3130/6-1), the Federal Ministry of
   Education and Research (DLR/BMBF; Kompetenznetz Degenerative Demenzen)
   and by a collaborative research grant of the Berlin Institute of Health
   (BIH). I.B. is supported by the Deutsche Forschungsgemeinsschaft (FOR
   1336 and SFB 1052), ICEMED and DZD. M.H.T. is supported by the Alexander
   von Humboldt Foundation, the Deutsches Zentrum fur Diabetesforschung
   (DZD), and the Helmholtz Alliance ICEMED-Imaging and Curing
   Environmental Metabolic Diseases, through the Initiative and Networking
   Fund of the Helmholtz Association.
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NR 145
TC 126
Z9 130
U1 1
U2 29
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 1759-5029
EI 1759-5037
J9 NAT REV ENDOCRINOL
JI Nat. Rev. Endocrinol.
PD JUN
PY 2015
VL 11
IS 6
BP 339
EP 351
DI 10.1038/nrendo.2015.48
PG 13
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA CI5OS
UT WOS:000354807700009
PM 25824676
DA 2025-06-11
ER

PT J
AU Jiang, PP
   Sangild, PT
AF Jiang, Pingping
   Sangild, Per Torp
TI Intestinal proteomics in pig models of necrotising enterocolitis, short
   bowel syndrome and intrauterine growth restriction
SO PROTEOMICS CLINICAL APPLICATIONS
LA English
DT Review
DE Birth; Intestine; IUGR; Milk; NEC; Newborn; Pig model; SBS
ID NF-KAPPA-B; ENDOPLASMIC-RETICULUM STRESS; GLUCAGON-LIKE PEPTIDE-2;
   PRETERM PIGS; BACTERIAL-COLONIZATION; ENTERAL NUTRITION; GUT MATURATION;
   NITRIC-OXIDE; ARGININE SUPPLEMENTATION; METABOLIC SYNDROME
AB Necrotising enterocolitis (NEC), short bowel syndrome (SBS) and intrauterine growth restriction (IUGR) are three conditions associated with intestinal dysfunction in newborn infants, particularly those born preterm. Piglet (Sus scrofa) models have recently been developed for NEC, SBS and IUGR, and tissue proteomic analyses have identified unknown pathways and new prognostic disease markers. Intestinal HSPs, iron metabolism proteins and proteins related to amino acid (e.g. arginine) and glucose metabolism are consistently affected by NEC progression and some of these proteins are also affected by SBS and IUGR. Parallel changes in some plasma and urinary proteins (e.g. haptoglobin, globulins, complement proteins, fatty acid binding proteins) may mirror the intestinal responses and pave the way to biomarker discovery. Explorative non-targeted proteomics provides ideas about the cellular pathways involved in intestinal adaptation during the critical neonatal period. Proteomics, combined with other -omic techniques, helps to get a more holistic picture of intestinal adaptation during NEC, SBS and IUGR. Explorative -omic research methods also have limitations and cannot replace, but only supplement, classical hypothesis-driven research that investigate disease mechanisms using a single or few endpoints.
C1 [Jiang, Pingping; Sangild, Per Torp] Univ Copenhagen, Dept Nutr Exercise & Sports, DK-1958 Frederiksberg C, Denmark.
C3 University of Copenhagen
RP Sangild, PT (corresponding author), Univ Copenhagen, Dept Nutr Exercise & Sports, 30 Rolighedsvej, DK-1958 Frederiksberg C, Denmark.
EM pts@nexs.ku.dk
RI JIANG, PINGPING/A-7286-2019
OI Jiang, Pingping/0000-0002-7393-9719; Sangild, Per
   Torp/0000-0002-5462-7760
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NR 138
TC 16
Z9 19
U1 0
U2 26
PU WILEY-V C H VERLAG GMBH
PI WEINHEIM
PA POSTFACH 101161, 69451 WEINHEIM, GERMANY
SN 1862-8346
EI 1862-8354
J9 PROTEOM CLIN APPL
JI Proteom. Clin. Appl.
PD OCT
PY 2014
VL 8
IS 9-10
SI SI
BP 700
EP 714
DI 10.1002/prca.201300097
PG 15
WC Biochemical Research Methods; Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA AQ6DX
UT WOS:000342900300007
PM 24634357
DA 2025-06-11
ER

PT J
AU Adams, LA
   Angulo, P
AF Adams, LA
   Angulo, P
TI Recent concepts in non-alcoholic fatty liver disease
SO DIABETIC MEDICINE
LA English
DT Review
DE cirrhosis; diabetes; non-alcoholic fatty liver disease; obesity
ID NECROSIS-FACTOR-ALPHA; INSULIN-RESISTANCE; HEPATIC STEATOSIS;
   HEPATOCELLULAR-CARCINOMA; METABOLIC SYNDROME; UNITED-STATES;
   RISK-FACTORS; TNF-ALPHA; FOLLOW-UP; VITAMIN-E
AB Non-alcoholic fatty liver disease (NAFLD) is present in up to one-third of the general population and in the majority of patients with metabolic risk factors such as obesity and diabetes. Insulin resistance is a key pathogenic factor resulting in hepatic fat accumulation. Recent evidence demonstrates NAFLD in turn exacerbates hepatic insulin resistance and often precedes glucose intolerance. Once hepatic steatosis is established, other factors, including oxidative stress, mitochondrial dysfunction, gut-derived lipopolysaccharide and adipocytokines, may promote hepatocellular damage, inflammation and progressive liver disease. Confirmation of the diagnosis of NAFLD can usually be achieved by imaging studies, however, staging the disease requires a liver biopsy. NAFLD is associated with an increased risk of all-cause death, probably because of complications of insulin resistance such as vascular disease, as well as cirrhosis and hepatocellular carcinoma, which occur in a minority of patients. NAFLD is also now recognized to account for a substantial proportion of patients previously diagnosed with 'cryptogenic cirrhosis'. Diabetes, obesity and the necroinflammatory form of NAFLD known as non-alcoholic steatohepatitis, are risk factors for progressive liver disease. Current treatment relies on weight loss and exercise, although various insulin-sensitizing medications appear promising. Further research is needed to identify which patients will achieve the most benefit from therapy.
C1 Mayo Clin, Div Gastroenterol & Hepatol, Coll Med, Rochester, MN 55905 USA.
   Univ Western Australia, Dept Med & Pharmacol, Perth, WA 6009, Australia.
C3 Mayo Clinic; University of Western Australia
RP Mayo Clin, Div Gastroenterol & Hepatol, Coll Med, 200 1st St SW, Rochester, MN 55905 USA.
EM angulohernandez.paul@mayo.edu
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NR 52
TC 237
Z9 271
U1 0
U2 23
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0742-3071
EI 1464-5491
J9 DIABETIC MED
JI Diabetic Med.
PD SEP
PY 2005
VL 22
IS 9
BP 1129
EP 1133
DI 10.1111/j.1464-5491.2005.01748.x
PG 5
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 955KM
UT WOS:000231224800001
PM 16108837
DA 2025-06-11
ER

PT J
AU Barber, T
   Neumiller, JJ
   Fravel, MA
   Page, RL II
   Tuttle, KR
AF Barber, Thelma
   Neumiller, Joshua J.
   Fravel, Michelle A.
   Page, Robert L.
   Tuttle, Katherine R.
TI Using guideline-directed medical therapies to improve kidney and
   cardiovascular outcomes in patients with chronic kidney disease
SO AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY
LA English
DT Article; Early Access
DE cardiovascular disease; cardiovascular-kidney-metabolic syndrome;
   chronic kidney disease; guideline-directed medical therapy;
   multidisciplinary care
ID REDUCED EJECTION FRACTION; HEART-FAILURE; OXIDATIVE STRESS; INHIBITION;
   LIRAGLUTIDE; CKD; NEPHROPATHY; MANAGEMENT; MORTALITY; EVENTS
AB Purpose An estimated 37 million people currently live with chronic kidney disease in the US, which places them at increased risk for kidney disease progression, cardiovascular disease, and mortality. This review discusses current standard-of-care management of patients with chronic kidney disease, identifies key gaps in care, and briefly highlights how pharmacists can address gaps in care as members of the multidisciplinary care team.Summary Recent advances in guideline-directed medical therapies for patients with chronic kidney disease, including agents from the sodium-glucose cotransporter, glucagon-like peptide-1 receptor agonist, and nonsteroidal mineralocorticoid receptor antagonist classes, can dramatically improve cardiovascular-kidney-metabolic care and outcomes. Unfortunately, gaps in screening, diagnosis, and implementation of recommended therapies persist. Team-based models of care-inclusive of the person with chronic kidney disease-have the potential to significantly improve care and outcomes for people with chronic kidney disease by addressing current gaps in care.Conclusion As members of the multidisciplinary care team, pharmacists can play a critical role in addressing current gaps in care, including optimized use of guideline-directed medical therapies, in patients with chronic kidney disease.
C1 [Barber, Thelma] Natl Kidney Fdn Vo Kidney Hlth, Boston, MA USA.
   [Neumiller, Joshua J.] Washington State Univ, Coll Pharm & Pharmaceut Sci, Dept Pharmacotherapy, Spokane, WA 99163 USA.
   [Neumiller, Joshua J.; Tuttle, Katherine R.] Providence Inland Northwest Hlth, Providence Med Res Ctr, Spokane, WA 99204 USA.
   [Fravel, Michelle A.] Univ Iowa, Coll Pharm, Div Appl Clin Sci, Iowa City, IA USA.
   [Page, Robert L.] Univ Colorado, Skaggs Sch Pharm & Pharmaceut Sci, Dept Clin Pharm, Aurora, CO USA.
   [Tuttle, Katherine R.] Univ Washington, Sch Med, Dept Med, Nephrol Div, Seattle, WA USA.
C3 Washington State University; University of Iowa; University of Colorado
   System; University of Colorado Anschutz Medical Campus; University of
   Washington; University of Washington Seattle
RP Neumiller, JJ (corresponding author), Washington State Univ, Coll Pharm & Pharmaceut Sci, Dept Pharmacotherapy, Spokane, WA 99163 USA.; Neumiller, JJ (corresponding author), Providence Inland Northwest Hlth, Providence Med Res Ctr, Spokane, WA 99204 USA.
EM jneumiller@wsu.edu
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NR 98
TC 0
Z9 0
U1 0
U2 0
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1079-2082
EI 1535-2900
J9 AM J HEALTH-SYST PH
JI Am. J. Health-Syst. Pharm.
PD 2025 APR 8
PY 2025
DI 10.1093/ajhp/zxaf045
EA APR 2025
PG 12
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 1BO9L
UT WOS:001461135800001
PM 40197743
DA 2025-06-11
ER

PT J
AU Song, G
   Gan, QY
   Qi, WT
   Wang, Y
   Xu, MH
   Li, Y
AF Song, Ge
   Gan, Qianyun
   Qi, Wentao
   Wang, Yong
   Xu, Meihong
   Li, Yong
TI Fructose Stimulated Colonic Arginine and Proline Metabolism Dysbiosis,
   Altered Microbiota and Aggravated Intestinal Barrier Dysfunction in
   DSS-Induced Colitis Rats
SO NUTRIENTS
LA English
DT Article
DE fructose; arginine and proline metabolism dysbiosis; metabolome
ID INFLAMMATORY-BOWEL-DISEASE; GUT; MECHANISMS; STRESS
AB The dysbiosis of intestinal microbiota and their metabolites is linked to the occurrence and development of metabolic syndrome. Although fructose has been proven to be associated with worsened mucus in the colon, its mechanism remains unclear. In this study, we evaluated the relatively low intake of sucrose and fructose in the experimental colitis of Sprague Dawley rats by investigating the microbiome and metabolome. Results showed that sucrose and fructose significantly reduced body weight, colon length and increased inflammation infiltration in colon. Sucrose and fructose worsen colon functions by inhibiting the expression of tight junction (TJ) protein ZO-1 and increasing the level of lipopolysaccharide neoandrographolide (LPS) in plasma, while fructose was more significant. Furthermore, sucrose and fructose significantly changed the composition of gut microbiota characterized by decreasing Adlercreutzia, Leuconostoc, Lactococcus and Oscillospira and increasing Allobaculum and Holdemania along with reducing histidine, phenylalanine, arginine, glycine, aspartic acid, serine, methionine valine, alanine, lysine, isoleucine, leucine, threonine, tryptophan, tyrosine, proline, citrulline, 4-hydroxyproline and gamma amino butyric acid (GABA). Metabolome results showed that fructose may aggravate experimental colitis symptoms by inducing amino metabolism dysbiosis in the colon. These findings suggested that fructose worsened colitis by manipulating the crosstalk between gut microbiota and their metabolites.
C1 [Song, Ge; Xu, Meihong; Li, Yong] Peking Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Beijing 100191, Peoples R China.
   [Song, Ge; Gan, Qianyun; Qi, Wentao; Wang, Yong] Acad Natl Food, Strateg Reserv Adm, Beijing 100037, Peoples R China.
   [Gan, Qianyun] Univ Shanghai Sci & Technol, Sch Hlth Sci & Engn, Shanghai 200093, Peoples R China.
C3 Peking University; University of Shanghai for Science & Technology
RP Li, Y (corresponding author), Peking Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Beijing 100191, Peoples R China.
EM liyongbmu@163.com
OI Wang, Yong/0000-0002-0123-228X; Xu, Meihong/0000-0001-7201-6982; Li,
   Yong/0000-0003-3914-5840
FU Special Funds of Basic Research of Central Public Welfare Institute
   [JY2010]; Young Elite Scientists Sponsorship Program by the China
   Association for Science and Technology [2019QNRC001]
FX This work was supported by the Special Funds of Basic Research of
   Central Public Welfare Institute (No. JY2010) and Young Elite Scientists
   Sponsorship Program by the China Association for Science and Technology
   (No. 2019QNRC001).
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NR 52
TC 21
Z9 22
U1 6
U2 37
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD FEB
PY 2023
VL 15
IS 3
AR 782
DI 10.3390/nu15030782
PG 17
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 8U8SS
UT WOS:000930215300001
PM 36771488
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Farag, MA
   Hamouda, S
   Gomaa, S
   Agboluaje, AA
   Hariri, MLM
   Yousof, SM
AF Farag, Mohamed A.
   Hamouda, Samia
   Gomaa, Suzan
   Agboluaje, Aishat A.
   Hariri, Mohamad Louai M.
   Yousof, Shimaa Mohammad
TI Dietary Micronutrients from Zygote to Senility: Updated Review of
   Minerals' Role and Orchestration in Human Nutrition throughout Life
   Cycle with Sex Differences
SO NUTRIENTS
LA English
DT Review
DE micronutrients; minerals; microelements intake; microminerals
   deficiency; malnutrition; life cycle
ID MOLYBDENUM-COFACTOR DEFICIENCY; SERUM COPPER; METABOLIC SYNDROME; IODINE
   DEFICIENCY; MILK CONSUMPTION; OXIDATIVE STRESS; SEVERE PNEUMONIA;
   SODIUM-FLUORIDE; IRON-METABOLISM; SELENIUM LEVELS
AB Micronutrients such as selenium, fluoride, zinc, iron, and manganese are minerals that are crucial for many body homeostatic processes supplied at low levels. The importance of these micronutrients starts early in the human life cycle and continues across its different stages. Several studies have emphasized the critical role of a well-balanced micronutrient intake. However, the majority of studies looked into or examined such issues in relation to a specific element or life stage, with the majority merely reporting the effect of either excess or deficiency. Herein, in this review, we will look in depth at the orchestration of the main element requirements across the human life cycle beginning from fertility and pregnancy, passing through infancy, childhood, adolescence, and reaching adulthood and senility, with insight on the interactions among them and underlying action mechanisms. Emphasis is given towards approaches to the role of the different minerals in the life cycle, associated symptoms for under- or overdoses, and typical management for each element, with future perspectives. The effect of sex is also discussed for each micronutrient for each life stage as literature suffice to highlight the different daily requirements and or effects.
C1 [Farag, Mohamed A.] Cairo Univ, Coll Pharm, Dept Pharmacognosy, Cairo 11562, Egypt.
   [Farag, Mohamed A.; Hamouda, Samia; Gomaa, Suzan; Agboluaje, Aishat A.; Hariri, Mohamad Louai M.] Amer Univ Cairo, Sch Sci & Engn, Dept Chem, New Cairo 11835, Egypt.
   [Yousof, Shimaa Mohammad] King Abdulaziz Univ, Fac Med Rabigh, Dept Med Physiol, Jeddah 21589, Saudi Arabia.
   [Yousof, Shimaa Mohammad] Suez Canal Univ, Fac Med, Dept Med Physiol, Ismailia 41522, Egypt.
C3 Egyptian Knowledge Bank (EKB); Cairo University; Egyptian Knowledge Bank
   (EKB); American University Cairo; King Abdulaziz University; Egyptian
   Knowledge Bank (EKB); Suez Canal University
RP Farag, MA (corresponding author), Cairo Univ, Coll Pharm, Dept Pharmacognosy, Cairo 11562, Egypt.; Farag, MA (corresponding author), Amer Univ Cairo, Sch Sci & Engn, Dept Chem, New Cairo 11835, Egypt.; Yousof, SM (corresponding author), King Abdulaziz Univ, Fac Med Rabigh, Dept Med Physiol, Jeddah 21589, Saudi Arabia.; Yousof, SM (corresponding author), Suez Canal Univ, Fac Med, Dept Med Physiol, Ismailia 41522, Egypt.
EM Mohamed.farag@pharma.cu.edu.eg; Samiasalah@aucegypt.edu;
   suzyaj@aucegypt.edu; agboluajeaishat@aucegypt.edu;
   hariri1994@aucegypt.edu; smabrahem@kau.edu.sa
RI Elseedi, Hesham/KGK-5692-2024; Yousof, Shimaa/Q-4715-2018
OI Agboluaje, Aishat/0000-0002-0463-9368; Hammouda, Samia
   Salah/0009-0005-1692-5731; farag, mohamed/0000-0001-5139-1863; Yousof,
   Shimaa/0000-0002-5996-8919
FU Institutional Fund [IFPRP:127-828-1442]
FX This research work was funded by Institutional Fund projects under grant
   number: (IFPRP:127-828-1442).
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NR 151
TC 14
Z9 14
U1 1
U2 27
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD NOV
PY 2021
VL 13
IS 11
AR 3740
DI 10.3390/nu13113740
PG 23
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA XI6UT
UT WOS:000726244600001
PM 34835995
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Polito, R
   Valenzano, A
   Scarinci, A
   Villano, I
   Monda, M
   Messina, A
   Cibelli, G
   Porro, C
   La Torre, E
   Pisanelli, D
   Moscatelli, F
   Messina, G
   Monda, V
AF Polito, Rita
   Valenzano, Anna
   Scarinci, Alessia
   Villano, Ines
   Monda, Marcellino
   Messina, Antonietta
   Cibelli, Giuseppe
   Porro, Chiara
   La Torre, Ester
   Pisanelli, Daniela
   Moscatelli, Fiorenzo
   Messina, Giovanni
   Monda, Vincenzo
TI Very Low-Calorie Ketogenic Diet Modulates the Autonomic Nervous System
   Activity through Salivary Amylase in Obese Population Subjects
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Article
DE salivary amylase; heart rate variability (HRV); autonomic nervous
   system; obesity; very low-calorie ketogenic diet (VLCKD); visceral
   adipose tissue (VAT)
ID HEART-RATE-VARIABILITY; LOW SERUM AMYLASE; METABOLIC SYNDROME; OXIDATIVE
   STRESS; ASSOCIATION; AMY1
AB In obesity, to reduce visceral adipose tissue (VAT), caloric restriction is a valid strategy. Salivary amylase is an enzyme that cleaves large starch carbohydrates molecules and its production is modulated by the central nervous system. In addition, heart rate variability (HRV) is simply a measure of the variation in time between each heartbeat. This variation is controlled by the autonomic nervous system. In the light of this evidence, the aim of this study is to characterize the effect of a very low-calorie ketogenic diet (VLCKD) on the autonomic nervous system in obese patients. Twenty subjects affected by obesity were recruited before and after 8 weeks of VLCKD intervention to evaluate salivary amylase by the ELISA test and HRV analysis. These parameters significantly increased after dietary treatment, and positively correlate to each other. VLCKD exerts a positive effect on salivary amylase and HRV, ameliorating body composition and biochemical features. In brief, this dietary intervention improves the autonomic nervous system activity. This is the first study about the effects of VLCKD upon the autonomic nervous system, but further studies are needed to elucidate the mechanism undergone VLCKD effects.
C1 [Polito, Rita] Univ Campania Luigi Vanvitelli, Dept Adv Med & Surg Sci, I-80138 Naples, Italy.
   [Polito, Rita; Valenzano, Anna; Cibelli, Giuseppe; Porro, Chiara; La Torre, Ester; Pisanelli, Daniela; Moscatelli, Fiorenzo; Messina, Giovanni] Univ Foggia, Dept Clin & Expt Med, Viale Pinto, I-71100 Foggia, Italy.
   [Scarinci, Alessia] Univ Bari, Dept Educ, Psychol, Commun, I-70121 Bari, Italy.
   [Villano, Ines; Monda, Marcellino; Messina, Antonietta; Monda, Vincenzo] Univ Campania Luigi Vanvitelli, Dept Expt Med, Sect Human Physiol, I-80138 Naples, Italy.
   [Villano, Ines; Monda, Marcellino; Messina, Antonietta; Monda, Vincenzo] Univ Campania Luigi Vanvitelli, Dept Expt Med, Unit Dietet & Sports Med, I-80138 Naples, Italy.
C3 Universita della Campania Vanvitelli; University of Foggia; Universita
   degli Studi di Bari Aldo Moro; Universita della Campania Vanvitelli;
   Universita della Campania Vanvitelli
RP Messina, G (corresponding author), Univ Foggia, Dept Clin & Expt Med, Viale Pinto, I-71100 Foggia, Italy.
EM rita.polito@unicampania.it; anna.valenzano@unifg.it;
   alessia.scarinci@uniba.it; ines.villano@unicampania.it;
   marcellino.monda@unicampania.it; antonietta.messina@unicampania.it;
   giuseppe.cibelli@unifg.it; chiara.porro@unifg.it;
   ester.latorre@unifg.it; daniela.pisanelli@gmail.com;
   fiorenzo400@gmail.com; Giovanni.messina@unifg.it;
   vincenzo.monda@unicampania.it
RI Messina, Giovanni/AAG-8573-2020; Messina, Giovanni/AAE-8668-2022;
   MESSINA, ANTONIETTA/K-9366-2016; Villano, Ines/ABU-5527-2022;
   Moscatelli, Fiorenzo/ABC-9536-2020; PORRO, CHIARA/G-7849-2018
OI Messina, Giovanni/0000-0002-0011-867X; Monda,
   Marcellino/0000-0002-7184-218X; Monda, Vincenzo/0000-0002-6083-5814;
   VILLANO, INES/0000-0002-1755-358X; Messina,
   Antonietta/0000-0001-8343-432X; PORRO, CHIARA/0000-0002-7526-6968; la
   Torre, Maria Ester/0000-0002-6035-7824; Moscatelli,
   Fiorenzo/0000-0003-1274-0332
FU Therascience, (Monaco)
FX The funding for the study as well as the high biological value protein
   preparations were provided by Therascience, (Monaco) free of charge to
   the patients. The funding source was not involved in the study design,
   recruitment of patients, study interventions, data collection or
   interpretation of the results.
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NR 44
TC 2
Z9 3
U1 0
U2 8
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD AUG
PY 2021
VL 18
IS 16
AR 8475
DI 10.3390/ijerph18168475
PG 10
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA UG3ZF
UT WOS:000689194100001
PM 34444230
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Gomez-Verjan, JC
   Barrera-Vázquez, OS
   García-Velázquez, L
   Samper-Ternent, R
   Arroyo, P
AF Gomez-Verjan, Juan C.
   Barrera-Vazquez, Oscar S.
   Garcia-Velazquez, Lizbeth
   Samper-Ternent, Rafael
   Arroyo, Pedro
TI Epigenetic variations due to nutritional status in early-life and its
   later impact on aging and disease
SO CLINICAL GENETICS
LA English
DT Article
DE aging; development; early-adversity; epigenetics; malnutrition; obesity
ID DIETARY-PROTEIN RESTRICTION; HIGHER METHYLATION LEVEL; LONG-TERM
   CONSEQUENCES; CORONARY-HEART-DISEASE; GREAT CHINESE FAMINE; GROWTH
   IN-UTERO; PRENATAL EXPOSURE; DUTCH FAMINE; METABOLIC SYNDROME; MATERNAL
   OBESITY
AB Epigenetics refers to changes in gene function, not resulting from the primary DNA sequence, influenced by the environment. It provides a link between the molecular regulation of the genome and the environmental signals exposed during the life of individuals (including lifestyle, social behavior, development, and nutrition). Notably, early development (intrauterine or postnatal) is highly influenced by the adverse socioeconomic status that leads to malnutrition or obesity; these conditions induce changes over the fetal epigenetic programming and can be transferred by transgenerational inheritance, inducing alterations of the transcription of genes related to several metabolic and neurological processes. Moreover, obesity during pregnancy, and excessive gestational weight gain are associated with an increased risk of fatal pregnancy complications, and adverse cardio-metabolic, respiratory and cognitive-related outcomes of the future child. However, most of our knowledge in this field comes from experimental animal models, that partially resemble the nutritional effects of humans. In this context, nutritional effects implicated in historical famines represent valuable information about the transgenerational effects of undernutrition and stress. In the present review, we attempt to describe the most outstanding results from the most studied famines about the impact of malnutrition on the epigenome.
C1 [Gomez-Verjan, Juan C.; Barrera-Vazquez, Oscar S.] Inst Nacl Geriatria INGER, Div Ciencias Basicas, Mexico City, DF, Mexico.
   [Garcia-Velazquez, Lizbeth] Univ Nacl Autonoma Mexico, Inst Invest Biomed, Dept Med Genom & Toxicol Ambiental, Mexico City, DF, Mexico.
   [Samper-Ternent, Rafael] Univ Texas Med Branch, Geriatr Sealy Ctr Aging, Galveston, TX 77555 USA.
   [Arroyo, Pedro] Inst Nacl Geriatria INGER, Div Epidemiol, Mexico City, DF, Mexico.
C3 Universidad Nacional Autonoma de Mexico; University of Texas System;
   University of Texas Medical Branch Galveston
RP Gomez-Verjan, JC (corresponding author), Inst Nacl Geriatria INGER, Basic Sci Div, Anillo Periferico 2767, Mexico City 10200, DF, Mexico.
EM carlosverjan@comunidad.unam.mx
RI Barrera-Vázquez, Oscar/AAP-6268-2021; Samper-Ternent,
   Rafael/HKW-7877-2023
OI Barrera-Vazquez, Oscar Salvador/0000-0003-1662-0872; Garcia-Velazquez,
   Lizbeth Esmeralda/0000-0003-2091-2130; Gomez Verjan, Juan
   Carlos/0000-0001-7186-8067; Samper-Ternent, Rafael/0000-0002-2250-9401
FU CONACYT-FOSISS [290287]
FX This project was supported by CONACYT-FOSISS 2017 number 290287 under
   the name: "Condiciones sociales y de salud al nacimiento, primera
   infancia y su relacion con las condiciones en la edad adulta y la
   expresion genomica, como predictores de envejecimiento saludable desde
   los 50 anos de edad."
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NR 120
TC 15
Z9 16
U1 1
U2 29
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0009-9163
EI 1399-0004
J9 CLIN GENET
JI Clin. Genet.
PD OCT
PY 2020
VL 98
IS 4
BP 313
EP 321
DI 10.1111/cge.13748
EA APR 2020
PG 9
WC Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Genetics & Heredity
GA NS0JE
UT WOS:000526566400001
PM 32246454
DA 2025-06-11
ER

PT J
AU Pech, LGM
   Caballero-Chacón, SD
   Guarner-Lans, V
   Díaz-Díaz, E
   Gómez, AM
   Pérez-Torres, I
AF Pech, Linaloe Guadalupe Manzano
   Caballero-Chacon, Sara del Carmen
   Guarner-Lans, Veronica
   Diaz-Diaz, Eulises
   Gomez, Adrian Moreno
   Perez-Torres, Israel
TI Effect of oophorosalpingo-hysterectomy on serum antioxidant enzymes in
   female dogs
SO SCIENTIFIC REPORTS
LA English
DT Article
ID OXIDATIVE STRESS; METABOLIC SYNDROME; STEROID-HORMONES; ESTROGEN;
   GLUTATHIONE; 17-BETA-ESTRADIOL; EXPRESSION; GENERATION; VARIABLES;
   BIOLOGY
AB There are few studies evaluating the oxidant-antioxidant status after oophorosalpingohysterectomy (OSH) in female dogs. Here we determined the effect of OSH on antioxidant enzymes in serum, and quantified morphological changes in subcutaneous adipocytes. Lateral OSH was performed in 12 female dogs. The concentration of 17 beta-estradiol (17 beta-E-2), the activities of extracellular superoxide dismutase (SOD-ec), glutathione peroxidase (GPx), glutathione-S-transferase (GST) and glutathione reductase (GR) were determined. Glutathione (GSH), glutathione disulfide (GSSG), lipid peroxidation (LPO), total antioxidant capacity (TAC), carbonylation and vitamin C were measured in serum. Subcutaneous adipose tissue was obtained to determine morphological changes and cell number, under basal conditions and six months after OSH. The SOD-ec, GPx and GST activities increased significantly (p <= 0.05), LPO, carbonylation and GSSG also increased. GSH and vitamin C decreased (p = 0.03). 17 beta-E-2 tended to decrease six months after OSH. Hypertrophy of subcutaneous adipocytes was observed after OSH from the first month and was accentuated after six months (p = 0.001). The results suggest that 17 beta-E-2 decreases after OSH and alters the antioxidant enzyme activities in serum thus, redox balance is altered. These changes are associated with an increase in body weight and hypertrophy of subcutaneous adipose tissue.
C1 [Pech, Linaloe Guadalupe Manzano; Perez-Torres, Israel] Inst Nacl Cardiol Ignacio Chavez, Dept Pathol, Juan Badiano 1,Secc 16, Mexico City 14080, DF, Mexico.
   [Caballero-Chacon, Sara del Carmen; Gomez, Adrian Moreno] Univ Nacl Autonoma Mexico, Fac Med Vet & Zootecnia, Dept Physiol & Pharmacol, Mexico City 04510, DF, Mexico.
   [Guarner-Lans, Veronica] Inst Nacl Cardiol Ignacio Chavez, Dept Physiol, Juan Badiano 1,Secc 16, Mexico City 14080, DF, Mexico.
   [Diaz-Diaz, Eulises] Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Reprod Biol, Vasco de Quiroga 15,Secc 16, Mexico City 14000, DF, Mexico.
C3 National Institute of Cardiology - Mexico; Universidad Nacional Autonoma
   de Mexico; National Institute of Cardiology - Mexico; Instituto Nacional
   de Ciencias Medicas y Nutricion Salvador Zubiran - Mexico
RP Pérez-Torres, I (corresponding author), Inst Nacl Cardiol Ignacio Chavez, Dept Pathol, Juan Badiano 1,Secc 16, Mexico City 14080, DF, Mexico.
RI V, Guarner/AFW-2513-2022; Pérez Torres, Israel/AAE-2579-2022
OI Perez-Torres, Israel/0000-0001-6510-2954
FU Postgraduate Section in the Program of Maestria y Doctorado en Ciencias
   de la Produccion y de la Salud Animal of the UNAM
FX Our thanks to the Postgraduate Section in the Program of Maestria y
   Doctorado en Ciencias de la Produccion y de la Salud Animal of the UNAM
   for a scholarship to Linaloe Guadalupe Manzano Pech. We thank Benito
   Chavez Renteria for histology technical support.
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NR 54
TC 12
Z9 12
U1 1
U2 4
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD JUL 4
PY 2019
VL 9
AR 9674
DI 10.1038/s41598-019-46204-w
PG 13
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA IH1AL
UT WOS:000474223600020
PM 31273281
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Torday, JS
   Miller, WB
AF Torday, John S.
   Miller, William B., Jr.
TI Unitary Physiology
SO COMPREHENSIVE PHYSIOLOGY
LA English
DT Article
ID HORMONE-RELATED PROTEIN; SIGNALING PATHWAYS; DEVELOPMENTAL ORIGINS;
   PULMONARY SURFACTANT; MESANGIAL CELLS; LUNG INJURY; EVOLUTION;
   MECHANISM; HOMEOSTASIS; ROLES
AB The common relationships among a great variety of biological phenomena seem enigmatic when considered solely at the level of the phenotype. The deep connections in physiology, for example, between the effects of maternal food restriction in utero and the subsequent incidence of metabolic syndrome in offspring, the effects of microgravity on cell polarity and reproduction in yeast, stress effects on jellyfish, and their endless longevity, or the relationship between nutrient abundance and the colonial form in slime molds, are not apparent by phenotypic observation. Yet all of these phenomena are ultimately determined by the Target of Rapamycin (TOR) gene and its associated signaling complexes. In the same manner, the unfolding of evolutionary physiology can be explained by a comparable application of the common principle of cell-cell signaling extending across complex developmental and phylogenetic traits. It is asserted that a critical set of physiologic and phenotypic adaptations emanated from a few crucial, ancestral receptor gene duplications that enabled the successful terrestrial transition of vertebrates from water to land. In combination, mTor and its cognate receptors and a few crucial genetic duplications provide a mechanistic common denominator across a diverse spectrum of biological responses. The proper understanding of their purpose yields a unified concept of physiology and its evolutionary development. (c) 2018 American Physiological Society.
C1 [Torday, John S.] Harbor UCLA Med Ctr, Dept Pediat, Torrance, CA 90509 USA.
C3 University of California System; University of California Los Angeles;
   University of California Los Angeles Medical Center
RP Torday, JS (corresponding author), Harbor UCLA Med Ctr, Dept Pediat, Torrance, CA 90509 USA.
EM jtorday@ucla.edu
OI Torday, John/0000-0001-9071-3052
FU NIH [HL055268]
FX J. S. Torday has been funded by NIH Grant HL055268.
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NR 147
TC 3
Z9 3
U1 0
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 2040-4603
J9 COMPR PHYSIOL
JI Compr. Physiol.
PD APR
PY 2018
VL 8
IS 2
BP 761
EP 771
DI 10.1002/cphy.c170035
PG 11
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA GL6DK
UT WOS:000437269100009
PM 29687904
DA 2025-06-11
ER

PT J
AU Venkatakrishnan, K
   Chiu, HF
   Cheng, JC
   Chang, YH
   Lu, YY
   Han, YC
   Shen, YC
   Tsai, KS
   Wang, CK
AF Venkatakrishnan, Kamesh
   Chiu, Hui-Fang
   Cheng, Ju-Chun
   Chang, Ya-Hui
   Lu, Yan-Ying
   Han, Yi-Chun
   Shen, You-Cheng
   Tsai, Kun-Shun
   Wang, Chin-Kun
TI Comparative studies on the hypolipidemic, antioxidant and
   hepatoprotective activities of catechin-enriched green and oolong tea in
   a double-blind clinical trial
SO FOOD & FUNCTION
LA English
DT Article
ID LOW-DENSITY-LIPOPROTEIN; MILD HYPERCHOLESTEROLEMIC ADULTS;
   CARDIOVASCULAR-DISEASE; HYPOCHOLESTEROLEMIC EFFICACY; METABOLIC
   SYNDROME; OXIDATIVE STRESS; RANDOMIZED-TRIAL; BLOOD-PRESSURE; LIPID
   PROFILE; PU-ERH
AB This study aimed to compare the beneficial effect of catechin-enriched green tea and oolong tea on mildly hypercholesterolemic subjects. Sixty mildly hypercholesterolemic subjects (180-220 mg dL(-1)) were enrolled and divided into three groups as catechin-enriched green tea (CEGT), catechin-enriched oolong tea (CEOT) or placebo. The subjects were instructed to drink 2 x 300 mL of CEGT (780.6 mg of catechin), CEOT (640.4 mg of catechin) or placebo beverage for 12 weeks. Drinking CEGT and CEOT significantly decreased (p < 0.05) the body weight, fat, and BMI, lipid peroxidation as well as lipid profile (TC, LDL-c, HDL-c, and TG). Also, intervention with CEGT and CEOT significantly improved (p < 0.05) the oxidative indices (TEAC and GSH) and antioxidant enzymes (SOD, CAT, GPx, and GR). Moreover, ultrasound examination endorsed the hepatoprotective activity of CEGT and CEOT by reverting mild fatty liver to the normal hepatic condition because of antioxidant and hypolipidemic activities. To summarize, both CEGT and CEOT showed similar antioxidant and hepatoprotective activities. However, CEOT displayed superior lipid-lowering activity compared to CEGT or placebo, and hence it could be used to amend the wellness condition of mildly hypercholesterolemic subjects.
C1 [Venkatakrishnan, Kamesh; Cheng, Ju-Chun; Chang, Ya-Hui; Han, Yi-Chun; Wang, Chin-Kun] Chung Shan Med Univ, Sch Nutr, 110,Sec 1,Jianguo North Rd, Taichung, Taiwan.
   [Chiu, Hui-Fang] Minist Hlth & Well Being, Taichung Hosp, Dept Chinese Med, Taichung, Taiwan.
   [Lu, Yan-Ying] Chung Shan Med Univ, Dept Neurol, Jianguo North Rd, Taichung, Taiwan.
   [Shen, You-Cheng] Chung Shan Med Univ, Sch Hlth Diet & Ind Management, 110,Sec 1,Jianguo North Rd, Taichung, Taiwan.
   [Tsai, Kun-Shun] Uni President Enterprises Corp, Cent R&D Inst, 301 Zhong Zheng Rd, Tainan, Taiwan.
C3 Chung Shan Medical University; Chung Shan Medical University; Chung Shan
   Medical University; Uni-President Enterprises
RP Wang, CK (corresponding author), Chung Shan Med Univ, Sch Nutr, 110,Sec 1,Jianguo North Rd, Taichung, Taiwan.
EM wck@csmu.edu.tw
RI Wang, Chin-Kun/S-6253-2019; Shen, You-Cheng/AAW-2665-2020; Chen,
   MingShing/KIL-7728-2024
FU Uni-President Enterprises Corporation, Tainan, Taiwan
FX This study was funded by Uni-President Enterprises Corporation, Tainan,
   Taiwan.
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NR 52
TC 46
Z9 48
U1 0
U2 46
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PD FEB
PY 2018
VL 9
IS 2
BP 1205
EP 1213
DI 10.1039/c7fo01449j
PG 9
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA GC6GB
UT WOS:000429887000049
PM 29384173
DA 2025-06-11
ER

PT J
AU Rasic, S
   Rebic, D
   Hasic, S
   Rasic, I
   Sarac, MD
AF Rasic, Senija
   Rebic, Damir
   Hasic, Sabaheta
   Rasic, Ismar
   Sarac, Marina Delic
TI Influence of Malondialdehyde and Matrix Metalloproteinase-9 on
   Progression of Carotid Atherosclerosis in Chronic Renal Disease with
   Cardiometabolic Syndrome
SO MEDIATORS OF INFLAMMATION
LA English
DT Article
ID CHRONIC KIDNEY-DISEASE; INTIMA-MEDIA THICKNESS; OXIDATIVE STRESS;
   PERITONEAL-DIALYSIS; CARDIOVASCULAR-DISEASE; MATRIX METALLOPROTEINASES;
   ENDOTHELIAL DYSFUNCTION; CIRCULATING MARKERS; METABOLIC SYNDROME; RISK
AB Objective was to assess whether the concentration of malondialdehyde (MDA) as a marker of lipid peroxidation and serum concentration of matrix metalloproteinase-9 (MMP-9) are involved in the process of atherosclerosis in chronic kidney disease (CKD) patients nondialysis-dependent and those on peritoneal dialysis (PD), both with signs of cardiometabolic syndrome (CMS). Thirty CKD and 22 PD patients were included in a study. All observed patients were divided into three subgroups depending on the degree of atherosclerotic changes in the carotid arteries (CA). Severity of atherosclerotic changes in the CA was evaluated by ultrasonography. We confirmed significantly lower level of serum MDA throughout all the stages of atherosclerosis in PD patients compared with observed CKD patients (P < 0.05) and increased serum concentration of MDA and MMP-9 with the progression of severity atherosclerotic changes in both groups of patients. The multiple regression analysis revealed that MDA and MMP-9 are significant predictors of changes in IMT-CA CKD patients (P < 0.05) and plaque score on CA in these patients (P < 0.05). The results suggest that MDA and MMP-9 could be mediators of CKD-related vascular remodeling in CMS.
C1 [Rasic, Senija; Rebic, Damir] Univ Sarajevo, Ctr Clin, Clin Nephrol, Sarajevo 71000, Bosnia & Herceg.
   [Hasic, Sabaheta] Univ Sarajevo, Fac Med, Dept Med Biochem, Sarajevo 71000, Bosnia & Herceg.
   [Rasic, Ismar] Univ Sarajevo, Ctr Clin, Clin Abdominal Surg, Sarajevo 71000, Bosnia & Herceg.
   [Sarac, Marina Delic] Univ Clin Ctr Sarajevo, Clin Immunol, Sarajevo, Bosnia & Herceg.
C3 University of Sarajevo; University of Sarajevo; University of Sarajevo;
   University of Sarajevo
RP Rasic, S (corresponding author), Univ Sarajevo, Ctr Clin, Clin Nephrol, Sarajevo 71000, Bosnia & Herceg.
EM rasicnef@bih.net.ba
RI Hasić, Sabaheta/ISU-6855-2023
OI Rebic, Damir/0000-0003-4296-9453; Hasic, Sabaheta/0000-0002-4193-9837
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   Yilmaz MI, 2006, AM J KIDNEY DIS, V47, P42, DOI 10.1053/j.ajkd.2005.09.029
NR 39
TC 10
Z9 11
U1 0
U2 2
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 0962-9351
EI 1466-1861
J9 MEDIAT INFLAMM
JI Mediat. Inflamm.
PY 2015
VL 2015
AR 614357
DI 10.1155/2015/614357
PG 8
WC Cell Biology; Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Immunology
GA CU5ZG
UT WOS:000363610000001
PM 26538831
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Ahlin, S
   Sjöholm, K
   Jacobson, P
   Andersson-Assarsson, JC
   Walley, A
   Tordjman, J
   Poitou, C
   Prifti, E
   Jansson, PA
   Borén, J
   Sjöström, L
   Froguel, P
   Bergman, RN
   Carlsson, LMS
   Olsson, B
   Svensson, PA
AF Ahlin, S.
   Sjoholm, K.
   Jacobson, P.
   Andersson-Assarsson, J. C.
   Walley, A.
   Tordjman, J.
   Poitou, C.
   Prifti, E.
   Jansson, P. -A.
   Boren, J.
   Sjostrom, L.
   Froguel, P.
   Bergman, R. N.
   Carlsson, L. M. S.
   Olsson, B.
   Svensson, P. -A.
TI Macrophage Gene Expression in Adipose Tissue is Associated with Insulin
   Sensitivity and Serum Lipid Levels Independent of Obesity
SO OBESITY
LA English
DT Article
ID ENDOPLASMIC-RETICULUM STRESS; METABOLIC SYNDROME; INFILTRATION;
   INFLAMMATION; RESISTANCE; FAT; DEFINITION; OVERWEIGHT; REDUCTION;
   PHENOTYPE
AB Objective: Obesity is linked to both increased metabolic disturbances and increased adipose tissue macrophage infiltration. However, whether macrophage infiltration directly influences human metabolism is unclear. The aim of this study was to investigate if there are obesity-independent links between adipose tissue macrophages and metabolic disturbances. Design and Methods: Expression of macrophage markers in adipose tissue was analyzed by DNA microarrays in the SOS Sib Pair study and in patients with type 2 diabetes and a BMI-matched healthy control group. Results: The expression of macrophage markers in adipose tissue was increased in obesity and associated with several metabolic and anthropometric measurements. After adjustment for BMI, the expression remained associated with insulin sensitivity, serum levels of insulin, C-peptide, high density lipoprotein cholesterol (HDL-cholesterol) and triglycerides. In addition, the expression of most macrophage markers was significantly increased in patients with type 2 diabetes compared to the control group. Conclusion: Our study shows that infiltration of macrophages in human adipose tissue, estimated by the expression of macrophage markers, is increased in subjects with obesity and diabetes and associated with insulin sensitivity and serum lipid levels independent of BMI. This indicates that adipose tissue macrophages may contribute to the development of insulin resistance and dyslipidemia.
C1 [Ahlin, S.; Sjoholm, K.; Jacobson, P.; Andersson-Assarsson, J. C.; Jansson, P. -A.; Boren, J.; Sjostrom, L.; Carlsson, L. M. S.; Olsson, B.; Svensson, P. -A.] Gothenburg Univ, Sahlgrenska Acad, Sahlgrenska Ctr Cardiovasc & Metab Res, Dept Mol & Clin Med, S-41345 Gothenburg, Sweden.
   [Walley, A.; Froguel, P.] Univ London Imperial Coll Sci Technol & Med, Hammersmith Hosp, Sch Publ Hlth, Dept Genom Common Dis, London W12 0NN, England.
   [Tordjman, J.; Poitou, C.; Prifti, E.] INSERM, U872, F-75007 Paris, France.
   [Tordjman, J.; Poitou, C.; Prifti, E.] Univ Paris 06, Ctr Rech Cordeliers, UMRS 872, F-75006 Paris, France.
   [Tordjman, J.; Poitou, C.; Prifti, E.] Univ Paris 05, UMRS 872, F-75006 Paris, France.
   [Bergman, R. N.] Cedars Sinai Diabet & Obes Res Inst, Dept Biomed Sci, Los Angeles, CA 90048 USA.
   [Bergman, R. N.] Cedars Sinai Diabet & Obes Res Inst, Dept Med, Los Angeles, CA 90048 USA.
   [Olsson, B.] Univ Gothenburg, Sahlgrenska Acad, Inst Neurosci & Physiol, Clin Neurochem Lab,Dept Neurochem & Psychiat, S-43180 Molndal, Sweden.
C3 University of Gothenburg; Imperial College London; Universite Paris
   Cite; Institut National de la Sante et de la Recherche Medicale
   (Inserm); Sorbonne Universite; Institut National de la Sante et de la
   Recherche Medicale (Inserm); Universite Paris Cite; Universite Paris
   Cite; Cedars Sinai Medical Center; Cedars Sinai Medical Center;
   University of Gothenburg
RP Svensson, PA (corresponding author), Gothenburg Univ, Sahlgrenska Acad, Sahlgrenska Ctr Cardiovasc & Metab Res, Dept Mol & Clin Med, S-41345 Gothenburg, Sweden.
EM per-arne.svensson@medic.gu.se
RI Bergman, Richard/B-9894-2013; Svensson, Per-Arne/R-4626-2019; Sjoholm,
   Kajsa/IQV-6550-2023; Carlsson Ekander, Lena/F-7570-2018; Froguel,
   Philippe/O-6799-2017; Andersson-Assarsson, Johanna/M-2524-2019; PRIFTI,
   EDI/F-3967-2019
OI Sjoholm, Kajsa/0000-0003-0146-8193; Svensson,
   Per-Arne/0000-0002-6731-806X; Carlsson Ekander,
   Lena/0000-0003-4145-6242; Froguel, Philippe/0000-0003-2972-0784;
   Bergman, Richard/0000-0003-1539-4471; Ahlin, Sofie/0000-0003-0619-2683;
   Jacobson, Peter/0000-0002-1769-1827; Olsson, Bob/0000-0002-6368-6172;
   Andersson-Assarsson, Johanna/0000-0001-9082-8589; PRIFTI,
   EDI/0000-0001-8861-1305
FU Swedish Research Council [K2008-65X-20753-01-4, K2009-65X-15424-05-3,
   K2010-55X-11285-13]; Swedish Foundation for Strategic Research; Swedish
   Diabetes Foundation; eke Wiberg Foundation; Foundations of the National
   Board of Health and Welfare; Jeansson Foundations; Magnus Bergvall
   Foundation; Royal Physiographic Society (Nilsson-Ehle Foundation); Tore
   Nilsson Foundation; Arosenius Foundation; Clas Groschinsky Foundation;
   Torsten and Ragnar S-derberg Foundation; VINNOVA-VINNMER program;
   Swedish federal government under the LUA/ALF agreement; Wellcome Trust
   [GR079534]; Hepadip consortium [LSHM-CT-2005-018734]; INSERM; FLIP7th
   framework program; "Programme Hospitalier de Recherche Clinique",
   Assistance Publique-Hpitaux de Paris [AOR 02076]; Contrat de Recherche
   Clinique (CRIC); MRC [G1002084] Funding Source: UKRI
FX The study was funded by the Swedish Research Council
   (K2008-65X-20753-01-4, K2009-65X-15424-05-3, K2010-55X-11285-13), the
   Swedish Foundation for Strategic Research to Sahlgrenska Center for
   Cardiovascular and Metabolic Research, the Swedish Diabetes Foundation,
   the eke Wiberg Foundation, the Foundations of the National Board of
   Health and Welfare, the Jeansson Foundations, the Magnus Bergvall
   Foundation, the Royal Physiographic Society (Nilsson-Ehle Foundation),
   the Tore Nilsson Foundation, the Arosenius Foundation, the Clas
   Groschinsky Foundation, the Torsten and Ragnar S-derberg Foundation, the
   VINNOVA-VINNMER program, the Swedish federal government under the
   LUA/ALF agreement, Wellcome Trust (GR079534), Hepadip consortium
   (http://www.hepadip.org/, contract LSHM-CT-2005-018734), INSERM and the
   FLIP7th framework program. Clinical work was supported by the "Programme
   Hospitalier de Recherche Clinique", Assistance Publique-Hpitaux de Paris
   (AOR 02076), the Contrat de Recherche Clinique (CRIC to CP).
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NR 39
TC 17
Z9 19
U1 0
U2 9
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1930-7381
EI 1930-739X
J9 OBESITY
JI Obesity
PD DEC
PY 2013
VL 21
IS 12
BP E571
EP E576
DI 10.1002/oby.20443
PG 6
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 288LT
UT WOS:000329614200007
PM 23512687
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Chen, LQ
   Fan, RJ
   Huang, XF
   Xu, H
   Zhang, XM
AF Chen, Liqing
   Fan, Ruijia
   Huang, Xiufeng
   Xu, Hong
   Zhang, Xinmei
TI Reduced Levels of Serum Pigment Epithelium-Derived Factor in Women With
   Endometriosis
SO REPRODUCTIVE SCIENCES
LA English
DT Article
DE endometriosis; serum; angiogenesis; pigment epithelium-derived factor
ID ENDOTHELIAL GROWTH-FACTOR; GLYCATION END-PRODUCTS; PERITONEAL-FLUID;
   OXIDATIVE STRESS; ANTIANGIOGENIC THERAPY; METABOLIC SYNDROME;
   PERIPHERAL-BLOOD; EXPRESSION; PEDF; RECEPTOR
AB The authors previously demonstrated decreased levels of pigment epithelium-derived factor (PEDF) in peritoneal fluid of women with endometriosis compared to women without endometriosis. Here, the authors determine whether women with endometriosis have altered levels of PEDF in serum. Peripheral blood samples were collected from 71 women with and without endometriosis (n = 43 and 28, respectively) before laparoscopic surgery. Concentrations of serum PEDF were measured by enzyme-linked immunosorbent assay. We detected lower levels of serum PEDF in women with endometriosis (16.3 +/- 6.6 ng/mL) than in those without endometriosis (24.5 +/- 7.3 ng/mL; P <.001). In women with endometriosis, the concentrations of serum PEDF were significantly lower in women with pain (n = 11, 12.6 +/- 7.1 ng/mL) compared to women without pain (n = 32, 17.5 +/- 6.0 ng/mL; P < .05). However, the concentrations of serum PEDF did not correlate with disease stage or site or infertility. In addition, the concentrations of serum PEDF did not show any difference in the phase of the cycle in either group. Our results suggest that reduced levels of serum PEDF in women with endometriosis and disease-related pain may play a role in the pathogenesis of this disease.
C1 [Chen, Liqing; Fan, Ruijia; Huang, Xiufeng; Xu, Hong; Zhang, Xinmei] Zhejiang Univ, Womens Hosp, Sch Med, Hangzhou 310006, Zhejiang, Peoples R China.
C3 Zhejiang University
RP Zhang, XM (corresponding author), Zhejiang Univ, Womens Hosp, Sch Med, 2 Xueshi Rd, Hangzhou 310006, Zhejiang, Peoples R China.
EM zhangxinmei20071116@yahoo.cn
RI HUANG, XIUFENG/HTP-2572-2023
OI HUANG, Xiufeng/0000-0002-0861-4045
FU National Natural Science Foundation of China [NSFC 81070468]
FX The authors disclosed receipt of the following financial support for the
   research, authorship, and/or publication of this article: supported by
   National Natural Science Foundation of China (NSFC 81070468).
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NR 53
TC 17
Z9 20
U1 1
U2 9
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1933-7191
J9 REPROD SCI
JI Reprod. Sci.
PD JAN
PY 2012
VL 19
IS 1
BP 64
EP 69
DI 10.1177/1933719111413300
PG 6
WC Obstetrics & Gynecology; Reproductive Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology; Reproductive Biology
GA 873BG
UT WOS:000298855000007
PM 22051848
DA 2025-06-11
ER

PT J
AU Haddad, Y
   Vallerand, D
   Brault, A
   Haddad, PS
AF Haddad, Yara
   Vallerand, Diane
   Brault, Antoine
   Haddad, Pierre S.
TI Antioxidant and Hepatoprotective Effects of Silibinin in a Rat Model of
   Nonalcoholic Steatohepatitis
SO EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Article
ID SILYBIN-PHOSPHATIDYLCHOLINE COMPLEX; FATTY LIVER-DISEASE; OXIDATIVE
   STRESS; MOLECULAR-MECHANISMS; BILIARY FIBROSIS; SILYMARIN; STEATOSIS;
   SECONDARY
AB Nonalcoholic steatohepatitis (NASH) is a progressive liver disease related to the metabolic syndrome, obesity and diabetes. The rising prevalence of NASH and the lack of efficient treatments have led to the exploration of different therapeutic approaches. Milk thistle (Silibum marianum) is a medicinal plant used for its hepatoprotective properties in chronic liver disease since the 4th century BC. We explored the therapeutic effect of silibinin, the plant's most biologically active extract, in an experimental rat NASH model. A control group was fed a standard liquid diet for 12 weeks. The other groups were fed a high-fat liquid diet for 12 weeks without (NASH) or with simultaneous daily supplement with silibinin-phosphatidylcholine complex (Silibinin 200 mg kg(-1)) for the last 5 weeks. NASH rats developed all key hallmarks of the pathology. Treatment with silibinin improved liver steatosis and inflammation and decreased NASH-induced lipid peroxidation, plasma insulin and TNF-alpha. Silibinin also decreasedO(2)(center dot-) release and returned the relative liver weight as well as GSH back to normal. Our results suggest that milk thistle's extract, silibinin, possesses antioxidant, hypoinsulinemic and hepatoprotective properties that act against NASH-induced liver damage. This medicinal herb thus shows promising therapeutic potential for the treatment of NASH.
C1 [Haddad, Yara; Vallerand, Diane; Brault, Antoine; Haddad, Pierre S.] Univ Montreal, Dept Pharmacol, Nat Hlth Prod & Metab Dis Lab, Montreal, PQ H3C 3J7, Canada.
   [Haddad, Yara; Vallerand, Diane; Brault, Antoine; Haddad, Pierre S.] Univ Montreal, Montreal Diabet Res Ctr, Montreal, PQ H3C 3J7, Canada.
   [Haddad, Yara; Vallerand, Diane; Brault, Antoine; Haddad, Pierre S.] Univ Laval, Inst Nutraceut & Funct Foods, Quebec City, PQ H3T 1J4, Canada.
C3 Universite de Montreal; Universite de Montreal; Laval University
RP Haddad, PS (corresponding author), Univ Montreal, Dept Pharmacol, Nat Hlth Prod & Metab Dis Lab, Montreal, PQ H3C 3J7, Canada.
EM pierre.haddad@umontreal.ca
FU Canadian Institutes of Health Research [CTP-79855]; National Science
   Council of Taiwan [NSC 96-2113-M-324-002-MY3]
FX Grant from the Canadian Institutes of Health Research [CTP-79855].The
   first author would like to thank the Ministry of Education, Taiwan for
   supporting her to conduct research in Taiwan. The assistance from
   National Science Council of Taiwan (NSC 96-2113-M-324-002-MY3) is also
   very much appreciated.
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NR 41
TC 59
Z9 62
U1 0
U2 20
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1741-427X
EI 1741-4288
J9 EVID-BASED COMPL ALT
JI Evid.-based Complement Altern. Med.
PY 2011
VL 2011
BP 1
EP 10
DI 10.1093/ecam/nep164
PG 10
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA 802PG
UT WOS:000293522900001
PM 19884114
OA Green Published, hybrid, Green Submitted
DA 2025-06-11
ER

PT J
AU Cervellati, C
   Pansini, FS
   Bonaccorsi, G
   Pascale, G
   Bagni, B
   Castaldini, C
   Ferrazini, S
   Ridolfi, F
   Pedriali, M
   Guariento, A
   Bergamini, CM
AF Cervellati, Carlo
   Pansini, Francesco Saverio
   Bonaccorsi, Gloria
   Pascale, Giuliana
   Bagni, Bruno
   Castaldini, Cristina
   Ferrazini, Stefania
   Ridolfi, Francesca
   Pedriali, Mery
   Guariento, Angela
   Bergamini, Carlo M.
TI Body mass index is a major determinant of abdominal fat accumulation in
   pre-, peri- and post-menopausal women
SO GYNECOLOGICAL ENDOCRINOLOGY
LA English
DT Article
DE Menopause; aging; body mass index; abdominal fat; dual X-ray
   absorptiometry
ID METABOLIC SYNDROME; OXIDATIVE STRESS; VISCERAL FAT; MENOPAUSE; AGE;
   RISK; OBESITY; DISEASE; WEIGHT
AB Objective. To investigate the role of menopause, body mass index (BMI) and aging on body fat distribution in women.
   Design. In this population-based cross-sectional study, 335 women (126 in pre-menopause, 75 in peri-menopause and 134 in post-menopause according to Stages of Reproductive Aging Workshop criteria) were evaluated for body mass composition and fat distribution by dual X-ray absorptiometry procedure. A sub-group of 79 women with similar age and BMI was extracted from the sample to examine the relative influence of BMI in body fat distribution.
   Results. ANCOVA analysis of total sample showed an age-independent increase of total fat mass (p<0.001) and percentage on total weight (p<0.001), arms fat mass (p<0.01), legs fat mass percentage on total fat (p<0.05) and trunk fat mass (p<0.001) and percentage (p<0.05) in peri- and post-with respect to pre-menopausal women. In the sub-sample including age and BMI matched women the difference of regional fat parameters among menopausal status was no more statistically significant.
   Conclusion. BMI, and not age, is the main determinant of the increase of body fat mass (total and abdominal) observed during the menopausal transition.
C1 [Cervellati, Carlo; Guariento, Angela; Bergamini, Carlo M.] Univ Ferrara, Dept Biochem & Mol Biol, I-44100 Ferrara, Italy.
   [Pansini, Francesco Saverio; Bonaccorsi, Gloria; Pascale, Giuliana; Castaldini, Cristina; Ferrazini, Stefania; Ridolfi, Francesca; Pedriali, Mery] Univ Ferrara, Menopause & Osteoporosis Ctr, I-44100 Ferrara, Italy.
   [Bagni, Bruno] Univ Modena, Dept Nucl Med, I-41100 Modena, Italy.
C3 University of Ferrara; University of Ferrara; Universita di Modena e
   Reggio Emilia
RP Pansini, FS (corresponding author), Univ Ferrara, Ctr Ric, Via Boschetto 29, I-44100 Ferrara, Italy.
EM pan@unife.it
RI BONACCORSI, GLORIA/AAC-6164-2022; Bergamini, Carlo/AAW-6958-2020;
   Cervellati, Carlo/K-6453-2015; Carlo, Bergamini/K-5664-2016
OI Cervellati, Carlo/0000-0003-4777-6300; BONACCORSI,
   GLORIA/0000-0001-5005-0274; Carlo, Bergamini/0000-0002-9430-8625;
   Pedriali, Massimo/0000-0003-3113-7352
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NR 26
TC 26
Z9 28
U1 2
U2 4
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0951-3590
EI 1473-0766
J9 GYNECOL ENDOCRINOL
JI Gynecol. Endocrinol.
PY 2009
VL 25
IS 6
BP 413
EP 417
DI 10.1080/09513590902770123
PG 5
WC Endocrinology & Metabolism; Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Obstetrics & Gynecology
GA 478SL
UT WOS:000268608500013
PM 19903034
DA 2025-06-11
ER

PT J
AU Bellar, A
   Jarosz, PA
   Bellar, D
AF Bellar, Ann
   Jarosz, Patricia A.
   Bellar, David
TI Implications of the biology of weight regulation and obesity on the
   treatment of obesity
SO JOURNAL OF THE AMERICAN ACADEMY OF NURSE PRACTITIONERS
LA English
DT Article
DE obesity; weight regulation; appetite regulation; biology of obesity;
   insulin sensitivity
ID CONDITIONED PLACE PREFERENCES; OXIDATIVE STRESS; INSULIN-RESISTANCE;
   CIRCULATING LEVELS; METABOLIC SYNDROME; VISCERAL FAT; SNACK FOODS;
   EXERCISE; LEPTIN; SYSTEM
AB Purpose: The purposes of this article are to provide a brief review of the complex biology of weight regulation and obesity, to explain some of the effects of diet and exercise on the biology of weight regulation and obesity, and to propose a coherent way to assess and treat people related to weight and obesity.
   Data sources: Scientific publications, clinical guidelines, and government sources.
   Conclusions: Obesity is a complex problem requiring an understanding of how interventions interact with the biology of weight regulation in people who are obese. Promoting health in obese people requires a focus on improving insulin sensitivity.
   Implications for practice: Helping individuals maintain normal weight throughout life is important in order to keep the long- and short-term weight signals in balance and reflective of true energy requirements. Exercise is associated with loss of total and abdominal adipose tissue and improved insulin sensitivity. Diets inducing gradual weight loss are less likely to stimulate appetite. Diets should include antioxidants to neutralize the increase in free radical production associated with obesity and exercise. Other interventions in the treatment of obesity may include treating sleep deficits and the dysregulated endocannabinoid system.
C1 [Bellar, Ann; Jarosz, Patricia A.] Wayne State Univ, Coll Nursing, Detroit, MI 48202 USA.
   [Bellar, David] Kent State Univ, Dept Exercise Leisure & Sports, Kent, OH 44242 USA.
C3 Wayne State University; University System of Ohio; Kent State
   University; Kent State University Salem; Kent State University Kent
RP Bellar, A (corresponding author), Wayne State Univ, Coll Nursing, 5557 Cass Ave, Detroit, MI 48202 USA.
EM ae9724@wayne.edu
RI Bellar, David/AAE-3907-2019
CR [Anonymous], 1998, NIH PUBL
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NR 35
TC 6
Z9 10
U1 0
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1041-2972
EI 1745-7599
J9 J AM ACAD NURSE PRAC
JI J. Am. Acad. Nurse Pract.
PD MAR
PY 2008
VL 20
IS 3
BP 128
EP 135
DI 10.1111/j.1745-7599.2007.00299.x
PG 8
WC Health Care Sciences & Services; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services; Nursing
GA 274CK
UT WOS:000253979200004
PM 18336689
OA Bronze
DA 2025-06-11
ER

PT J
AU Matsuzaka, T
   Shimano, H
   Yahagi, N
   Kato, T
   Atsumi, A
   Yamamoto, T
   Inoue, N
   Ishikawa, M
   Okada, S
   Ishigaki, N
   Iwasaki, H
   Iwasaki, Y
   Karasawa, T
   Kumadaki, S
   Matsui, T
   Sekiya, M
   Ohashi, K
   Hasty, AH
   Nakagawa, Y
   Takahashi, A
   Suzuki, H
   Yatoh, S
   Sone, H
   Toyoshima, H
   Osuga, JI
   Yamada, N
AF Matsuzaka, Takashi
   Shimano, Hitoshi
   Yahagi, Naoya
   Kato, Toyonori
   Atsumi, Ayaka
   Yamamoto, Takashi
   Inoue, Noriyuki
   Ishikawa, Mayumi
   Okada, Sumiyo
   Ishigaki, Naomi
   Iwasaki, Hitoshi
   Iwasaki, Yuko
   Karasawa, Tadayoshi
   Kumadaki, Shin
   Matsui, Toshiyuki
   Sekiya, Motohiro
   Ohashi, Ken
   Hasty, Alyssa H.
   Nakagawa, Yoshimi
   Takahashi, Akimitsu
   Suzuki, Hiroaki
   Yatoh, Sigeru
   Sone, Hirohito
   Toyoshima, Hideo
   Osuga, Jun-ichi
   Yamada, Nobuhiro
TI Crucial role of a long-chain fatty acid elongase, Elovl6, in
   obesity-induced insulin resistance
SO NATURE MEDICINE
LA English
DT Article
ID STEAROYL-COA DESATURASE-1; ACTIVATED PROTEIN-KINASE; ELEMENT-BINDING
   PROTEINS; MICE LACKING; TRANSCRIPTION FACTOR; METABOLIC SYNDROME;
   LIPID-METABOLISM; LIVER-DISEASE; IKK-BETA; SENSITIVITY
AB Insulin resistance is often associated with obesity and can precipitate type 2 diabetes. To date, most known approaches that improve insulin resistance must be preceded by the amelioration of obesity and hepatosteatosis. Here, we show that this provision is not mandatory; insulin resistance and hyperglycemia are improved by the modification of hepatic fatty acid composition, even in the presence of persistent obesity and hepatosteatosis. Mice deficient for Elovl6, the gene encoding the elongase that catalyzes the conversion of palmitate to stearate, were generated and shown to become obese and develop hepatosteatosis when fed a high- fat diet or mated to leptin- deficient ob/ ob mice. However, they showed marked protection from hyperinsulinemia, hyperglycemia and hyperleptinemia. Amelioration of insulin resistance was associated with restoration of hepatic insulin receptor substrate- 2 and suppression of hepatic protein kinase C e activity resulting in restoration of Akt phosphorylation. Collectively, these data show that hepatic fatty acid composition is a new determinant for insulin sensitivity that acts independently of cellular energy balance and stress. Inhibition of this elongase could be a new therapeutic approach for ameliorating insulin resistance, diabetes and cardiovascular risks, even in the presence of a continuing state of obesity.
C1 Univ Tsukuba, Grad Sch Comprehens Human Sci, Dept Internal Med Endocrinol & Metab, Tsukuba, Ibaraki 3058575, Japan.
   Univ Tsukuba, Ctr Tsukuba Adv Res Alliance, Tsukuba, Ibaraki 3058575, Japan.
   Univ Tokyo, Dept Metab Dis, Bunkyo Ku, Tokyo 1138655, Japan.
   Vanderbilt Univ, Med Ctr, Dept Mol Physiol & Biophys, Nashville, TN 37232 USA.
C3 University of Tsukuba; University of Tsukuba; University of Tokyo;
   Vanderbilt University
RP Shimano, H (corresponding author), Univ Tsukuba, Grad Sch Comprehens Human Sci, Dept Internal Med Endocrinol & Metab, 1-1-1 Tennodai, Tsukuba, Ibaraki 3058575, Japan.
EM shimano-tky@umin.ac.jp
RI Inoue, Noriyuki/W-4614-2018; Hasty, Alyssa/AAA-2757-2020; Shimano,
   Hitoshi/V-1761-2019; Yahagi, Naoya/D-2360-2014; Sone,
   Hirohito/ABC-9346-2021
OI Yahagi, Naoya/0000-0002-1823-1865; Sone, Hirohito/0000-0003-1263-2817;
   Hasty, Alyssa/0000-0001-7302-8045; Karasawa,
   Tadayoshi/0000-0002-6738-2360; Shimano, Hitoshi/0000-0002-5562-5572
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NR 50
TC 427
Z9 476
U1 2
U2 73
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 1078-8956
EI 1546-170X
J9 NAT MED
JI Nat. Med.
PD OCT
PY 2007
VL 13
IS 10
BP 1193
EP 1202
DI 10.1038/nm1662
PG 10
WC Biochemistry & Molecular Biology; Cell Biology; Medicine, Research &
   Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology; Research & Experimental
   Medicine
GA 217XI
UT WOS:000249980200035
PM 17906635
DA 2025-06-11
ER

PT J
AU Sanz, J
   Moreno, PR
   Fuster, V
AF Sanz, Javier
   Moreno, Pedro R.
   Fuster, Valentin
TI Update on advances in atherothrombosis
SO NATURE CLINICAL PRACTICE CARDIOVASCULAR MEDICINE
LA English
DT Review
DE atherosclerosis; drugs; imaging; molecular biology; risk factors
ID C-REACTIVE-PROTEIN; CORONARY-HEART-DISEASE; CARDIOVASCULAR RISK-FACTORS;
   SPIRAL COMPUTED-TOMOGRAPHY; BRAIN NATRIURETIC PEPTIDE;
   MYOCARDIAL-INFARCTION; HIGH-RESOLUTION; PRIMARY PREVENTION; METABOLIC
   SYNDROME; GENE-EXPRESSION
AB The study of atherothrombosis is a rapidly evolving field, and significant progress was achieved in various aspects of the disease during the past year. In the area of diagnostic imaging, MRI and multidetector CT were actively used to evaluate the characteristics of the arterial wall, including calcified and noncalcified lesions, and both in the coronary and extracoronary vascular territories. There was also extensive research into the application of imaging modalities to visualize cellular or molecular disease processes, known as molecular imaging. Considerable efforts were devoted to the identification of novel biomarkers that reflect different components of atherothrombosis, namely inflammation, thrombogenicity, oxidative stress and reparative ability, predicting the presence of early disease or the risk of clinical events. In the therapeutic arena, substantial evidence accumulated on the beneficial effects of several pharmacologic agents, most significantly statins. Finally, important advances were also made in the understanding of the roles of immunity and neovascularization in atherogenesis, including the development and progression of disease at different stages. Awareness of these recent advances and new lines of active research is fundamental for health professionals involved in the care of patients with atherothrombosis. In this Review we present an overview of data in these areas.
C1 Mt Sinai Sch Med, Marie Josee & Henry R Kravis Ctr Cardiovasc Hlth, Zena & Michael A Wiener Cardiovasc Inst, New York, NY 10029 USA.
C3 Icahn School of Medicine at Mount Sinai
RP Fuster, V (corresponding author), Mt Sinai Sch Med, Marie Josee & Henry R Kravis Ctr Cardiovasc Hlth, Zena & Michael A Wiener Cardiovasc Inst, Box 1030,1 Gustave L Levy Pl, New York, NY 10029 USA.
EM valentin.fuster@mssm.edu
RI Sanz, Javier/HNJ-5571-2023; Fuster, Valentin/H-4319-2015
OI Fuster, Valentin/0000-0002-9043-9986
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NR 80
TC 13
Z9 13
U1 0
U2 4
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1743-4297
J9 NAT CLIN PRACT CARD
JI Nat. Clin. Pract. Cardiovasc. Med.
PD FEB
PY 2007
VL 4
IS 2
BP 78
EP 89
DI 10.1038/ncpcardio0774
PG 12
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 129KY
UT WOS:000243729600008
PM 17245402
DA 2025-06-11
ER

PT J
AU Rani, KS
   Aruna, M
   Lakshmi, K
   Priya, BT
   Prakash, KK
AF Rani, K. Sudha
   Aruna, M.
   Lakshmi, K.
   Priya, B. Tanuja
   Prakash, K. Kiran
TI A comprehensive review of the antioxidative and anti-inflammatory
   properties of Turmeric (Curcuma longa L.)
SO ANNALS OF PHYTOMEDICINE-AN INTERNATIONAL JOURNAL
LA English
DT Review
DE Turmeric; Curcumin; Anti-inflammatory; Antioxidative; Chronic
   inflammation; Oxidative stress; Bioactive compounds
ID GENE-EXPRESSION; TNF-ALPHA; RESVERATROL; APOPTOSIS; SPICE;
   SUPPLEMENTATION; MECHANISMS; LEVEL; GPX
AB Turmeric (Curcuma longa L.), belongs to the ginger family and is known for its medicinal properties in traditional healing systems such as Ayurveda and conventional medicine. The key bioactive compound in turmeric, curcumin, has drawn significant scientific interest due to its potent anti-inflammatory and antioxidant properties, by modifying important pathways, such as the suppression of cyclooxygenase-2 (COX-2) and nuclear factor kappa B (NF-KB), curcumin reduces the generation of pro-inflammatory cytokines and has anti-inflammatory effects. Additionally, curcumin is a powerful antioxidant that increases the activity of endogenous antioxidant enzymes by scavenging free radicals and activating the Nrf2 pathway, which regulates cellular defense mechanisms. Several clinical studies have demonstrated turmeric's potential in treating inflammation-driven conditions such as rheumatoid arthritis, cardiovascular disease, neurodegenerative disorders, and metabolic syndrome. However, challenges with curcumin's bioavailability limit its widespread therapeutic use. Emerging research on delivery systems such as nanoparticles and liposomal formulations aims to address these limitations. Moreover, combining curcumin with compounds like piperine has been shown to improve its absorption. This review provides an overview of turmeric's anti-inflammatory and antioxidative mechanisms, clinical evidence supporting its use, and future directions to enhance its efficacy and therapeutic potential in modern medicine.
C1 [Rani, K. Sudha] ANGRAU, Krishi Vigyan Kendra, Ananthapuramu 515701, Andhra Pradesh, India.
   [Aruna, M.] Sri Padmavati Mahila Visvavidyalayam, Dept Home Sci, Tirupati 517502, India.
   [Lakshmi, K.] ANGRAU, Coll Community Sci, Dept Foods & Nutr, Guntur 522034, Andhra Pradesh, India.
   [Priya, B. Tanuja] Dr YSRHU Lam, Dept Hort, Hort Res Stn, Guntur 522034, Andhra Pradesh, India.
   [Prakash, K. Kiran] ANGRAU, Agr Coll, Dept Stat & Comp Applicat, Bapatla 522101, Andhra Pradesh, India.
C3 Acharya N. G. Ranga Agricultural University; Sri Padmavati Mahila
   Vishwavidyalayam; Acharya N. G. Ranga Agricultural University; Acharya
   N. G. Ranga Agricultural University
RP Rani, KS (corresponding author), ANGRAU, Home Sci, Krishi Vigyan Kendra, Ananthapuramu 515701, Andhra Pradesh, India.
EM sudharani@angrau.ac.in
RI B, Tanuja/LRS-9495-2024; Rani, Dr.K.Sudha/GLQ-6885-2022
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NR 118
TC 0
Z9 0
U1 4
U2 4
PU UKAAZ PUBLICATIONS
PI HYDERABAD
PA 16-11-511/D/408, SHALIVAHANA NAGAR, MOOSARAMBAGH, HYDERABAD, 500036,
   INDIA
SN 2393-9885
EI 2278-9839
J9 ANN PHYTOMEDICINE
JI Ann. Phytomedicine
PD JUL-DEC
PY 2024
VL 13
IS 2
BP 96
EP 105
DI 10.54085/ap.2024.13.2.10
PG 10
WC Pharmacology & Pharmacy
WE Emerging Sources Citation Index (ESCI)
SC Pharmacology & Pharmacy
GA 0DR7R
UT WOS:001444910400004
OA gold
DA 2025-06-11
ER

PT J
AU Stull, AJ
   Cassidy, A
   Djousse, L
   Johnson, SA
   Krikorian, R
   Lampe, JW
   Mukamal, KJ
   Nieman, DC
   Starr, KNP
   Rasmussen, H
   Rimm, EB
   Stote, KS
   Tangney, C
AF Stull, April J.
   Cassidy, Aedin
   Djousse, Luc
   Johnson, Sarah A.
   Krikorian, Robert
   Lampe, Johanna W.
   Mukamal, Kenneth J.
   Nieman, David C.
   Starr, Kathryn N. Porter
   Rasmussen, Heather
   Rimm, Eric B.
   Stote, Kim S.
   Tangney, Christy
TI The state of the science on the health benefits of blueberries: a
   perspective
SO FRONTIERS IN NUTRITION
LA English
DT Article
DE blueberry; anthocyanins; cardiovascular disease; cognitive function;
   exercise; gut microbiome; diabetes; vascular function
ID PERIPHERAL ARTERIAL DYSFUNCTION; SUPPLEMENTATION IMPROVES MEMORY;
   KILLER-CELL COUNTS; DOUBLE-BLIND; METABOLIC SYNDROME; OXIDATIVE STRESS;
   NEURONAL FUNCTION; GUT MICROBIOTA; BLOOD-PRESSURE; OLDER-ADULTS
AB Mounting evidence indicates that blueberry consumption is associated with a variety of health benefits. It has been suggested that regular consumption of blueberries can support and/or protect against cardiovascular disease and function, pre-diabetes and type 2 diabetes, and brain and cognitive function in individuals with health conditions and age-related decline. Further, mechanistic investigations highlight the role of blueberry anthocyanins in mediating these health benefits, in part through interactions with gut microbiota. Also, nutritional interventions with blueberries have demonstrated the ability to improve recovery following exercise-induced muscle damage, attributable to anti-inflammatory effects. Despite these advancements in blueberry health research, research gaps persist which affects the generalizability of findings from clinical trials. To evaluate the current state of knowledge and research gaps, a blueberry health roundtable with scientific experts convened in Washington, DC (December 6-7, 2022). Discussions centered around five research domains: cardiovascular health, pre-diabetes and diabetes, brain health and cognitive function, gut health, and exercise recovery. This article synthesizes the outcomes of a blueberry research roundtable discussion among researchers in these domains, offering insights into the health benefits of blueberries and delineating research gaps and future research directions.
C1 [Stull, April J.] Baylor Univ, Dept Human Sci & Design, Waco, TX 76706 USA.
   [Cassidy, Aedin] Queens Univ Belfast, Inst Global Food Secur, Belfast, North Ireland.
   [Djousse, Luc] Brigham & Womens Hosp, Dept Med, Boston, MA USA.
   [Djousse, Luc; Rimm, Eric B.] Harvard Med Sch, Boston, MA USA.
   [Johnson, Sarah A.] Colorado State Univ, Dept Food Sci & Human Nutr, Ft Collins, CO USA.
   [Krikorian, Robert] Univ Cincinnati, Dept Psychiat & Behav Neurosci, Acad Hlth Ctr, Cincinnati, OH USA.
   [Lampe, Johanna W.] Fred Hutchinson Canc Ctr, Publ Hlth Sci Div, Seattle, WA USA.
   [Mukamal, Kenneth J.] Harvard Med Sch, Beth Israel Deaconess Med Ctr, Boston, MA USA.
   [Nieman, David C.; Starr, Kathryn N. Porter] Appalachian State Univ, Human Performance Lab, North Carolina Res Campus, Kannapolis, NC USA.
   Duke Univ, Res Educ & Clin Ctr, Dept Med, Durham VA Hlth Care Syst,Sch Med & Geriatr, Durham, NC USA.
   [Rasmussen, Heather] Univ Nebraska Lincoln, Dept Nutr & Hlth Sci, Lincoln, NE USA.
   [Rimm, Eric B.] Brigham & Womens Hosp, Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Channing Div Network Med, Boston, MA USA.
   [Rimm, Eric B.] Brigham & Womens Hosp, Harvard TH Chan Sch Publ Hlth, Dept Nutr, Channing Div Network Med, Boston, MA USA.
   [Stote, Kim S.] Albany Stratton VA Med Ctr, Albany, NY USA.
   [Tangney, Christy] Rush Univ, Dept Clin Nutr, Chicago, IL USA.
C3 Baylor University; Queens University Belfast; Harvard University;
   Harvard University Medical Affiliates; Brigham & Women's Hospital;
   Harvard University; Harvard Medical School; Colorado State University
   System; Colorado State University Fort Collins; University System of
   Ohio; University of Cincinnati; Fred Hutchinson Cancer Center; Harvard
   University; Harvard University Medical Affiliates; Beth Israel Deaconess
   Medical Center; Harvard Medical School; University of North Carolina;
   Appalachian State University; Duke University; University of Nebraska
   System; University of Nebraska Lincoln; Harvard University; Harvard
   University Medical Affiliates; Brigham & Women's Hospital; Harvard T.H.
   Chan School of Public Health; Harvard University; Harvard T.H. Chan
   School of Public Health; Harvard University Medical Affiliates; Brigham
   & Women's Hospital; Rush University
RP Stull, AJ (corresponding author), Baylor Univ, Dept Human Sci & Design, Waco, TX 76706 USA.
EM april_stull@baylor.edu
RI Johnson, Sarah/AAP-2170-2020; Mukamal, Kenneth/GVR-7978-2022; Nieman,
   David/AAC-9739-2022; Djousse, Luc/F-5033-2017
FU United States Highbush Blueberry Council (USHBC); USHBC
FX The author(s) declare that financial support was received for the
   research, authorship, and/or publication of this article. This expert
   roundtable, including evaluation of research, was funded by the United
   States Highbush Blueberry Council (USHBC). USHBC were observers at the
   roundtable discussion but were not involved in the conceptualization and
   writing of this manuscript or the decision to submit it for publication.
   USHBC is an agricultural federal research and promotion board
   established by the United States Department of Agriculture (USDA). USHBC
   is funded by its members who are blueberry farmers, processors, and
   importers. USHBC does not sell any products and operates with
   independent oversight from the USDA.r The author(s) declare that
   financial support was received for the research, authorship, and/or
   publication of this article. This expert roundtable, including
   evaluation of research, was funded by the United States Highbush
   Blueberry Council (USHBC). USHBC were observers at the roundtable
   discussion but were not involved in the conceptualization and writing of
   this manuscript or the decision to submit it for publication. USHBC is
   an agricultural federal research and promotion board established by the
   United States Department of Agriculture (USDA). USHBC is funded by its
   members who are blueberry farmers, processors, and importers. USHBC does
   not sell any products and operates with independent oversight from the
   USDA.
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NR 94
TC 7
Z9 7
U1 7
U2 15
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD JUN 11
PY 2024
VL 11
AR 1415737
DI 10.3389/fnut.2024.1415737
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA XL1F2
UT WOS:001261741100001
PM 38919390
OA Green Published
DA 2025-06-11
ER

PT J
AU Lü, H
   Meng, XH
   Ding, XQ
   Jian, TY
   Zuo, YY
   Liu, Y
   Ren, BR
   Li, WL
   Chen, J
AF Lu, Han
   Meng, Xiuhua
   Ding, Xiaoqin
   Jian, Tunyu
   Zuo, Yuanyuan
   Liu, Yan
   Ren, Bingru
   Li, Weilin
   Chen, Jian
TI Gallotannin Isolated from Pericarp of Water Caltrop Ameliorates High-Fat
   Diet-Induced Nonalcoholic Fatty Liver Disease in Mice
SO JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
LA English
DT Article
DE gallotannin; water caltrop pericarp; NAFLD; lipid accumulation; insulin
   resistance; gut microbiome
ID INSULIN-RESISTANCE; PATHOGENESIS; STEATOSIS
AB Nonalcoholic fatty liver disease (NAFLD) is a worldwide prevalent chronic liver disease characterized by hepatic steatosis. Water caltrop, the fruit of Trapa natan, is widely cultivated as an edible vegetable in Asian countries. In China, water caltrop pericarp has long been used as a functional food to treat metabolic syndrome, yet the bioactive substances and their pharmacological mechanisms remain unclear. In this study, a natural gallotannin, 1,2,3,6-tetra-O-galloyl-beta-D-glucopyranoside (GA), was isolated from water caltrop pericarp and evaluated for its therapeutic effect on NAFLD. Treatment of GA (15 and 30 mg/kg/ day) suppressed the body weight gain (p < 0.001) and ameliorated lipid deposition (p < 0.001) in high-fat diet (HFD)-induced NAFLD mice. GA was able to alleviate HFD-induced insulin resistance (p < 0.001), oxidative stress (p < 0.001), and inflammation (p < 0.001), thereby restoring the liver function in HFD-induced NAFLD mice. Mechanistically, GA diminished the aberrant signaling pathways including AMPK/SREBP/ACC, IRs-1/Akt, IKK/I kappa B/NF-kappa B in HFD-induced NAFLD mice and modified gut microbiota dysbiosis in these mice as well. The current findings suggest that GA is a promising novel agent for NAFLD therapy.
C1 [Lu, Han; Meng, Xiuhua; Ding, Xiaoqin; Jian, Tunyu; Zuo, Yuanyuan; Liu, Yan; Ren, Bingru; Chen, Jian] Inst Bot, Jiangsu Key Lab Res & Utilizat Plant Resources, Nanjing 210014, Jiangsu, Peoples R China.
   [Lu, Han; Meng, Xiuhua; Ding, Xiaoqin; Jian, Tunyu; Zuo, Yuanyuan; Liu, Yan; Ren, Bingru; Chen, Jian] Chinese Acad Sci, Nanjing Bot Garden Mem Sun Yat Sen, Nanjing 210014, Peoples R China.
   [Li, Weilin] Nanjing Forestry Univ, Forestry Coll, Coinnovat Ctr Sustainable Forestry Southern China, Nanjing 210037, Peoples R China.
C3 Chinese Academy of Sciences; Nanjing Forestry University
RP Chen, J (corresponding author), Inst Bot, Jiangsu Key Lab Res & Utilizat Plant Resources, Nanjing 210014, Jiangsu, Peoples R China.; Chen, J (corresponding author), Chinese Acad Sci, Nanjing Bot Garden Mem Sun Yat Sen, Nanjing 210014, Peoples R China.
EM chenjian80@aliyun.com
RI Jian, Tunyu/B-5601-2018
OI Jian, Tunyu/0000-0002-9814-500X; Lu, Han/0000-0003-4452-4351
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NR 38
TC 5
Z9 6
U1 3
U2 28
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0021-8561
EI 1520-5118
J9 J AGR FOOD CHEM
JI J. Agric. Food Chem.
PD MAY 10
PY 2023
VL 71
IS 18
BP 7046
EP 7057
DI 10.1021/acs.jafc.3c01099
EA APR 2023
PG 12
WC Agriculture, Multidisciplinary; Chemistry, Applied; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture; Chemistry; Food Science & Technology
GA G1AS5
UT WOS:000983659000001
PM 37113100
DA 2025-06-11
ER

PT J
AU Chavda, VP
   Chaudhari, AZ
   Teli, D
   Balar, P
   Vora, L
AF Chavda, Vivek P.
   Chaudhari, Amit Z.
   Teli, Divya
   Balar, Pankti
   Vora, Lalitkumar
TI Propolis and Their Active Constituents for Chronic Diseases
SO BIOMEDICINES
LA English
DT Review
DE propolis; chronic kidney disease; rheumatoid arthritis; cancer;
   diabetes; metabolic syndrome and its associated chronic disease
ID ACID PHENETHYL ESTER; BRAZILIAN GREEN PROPOLIS; OXIDATIVE STRESS;
   DOUBLE-BLIND; INSULIN-RESISTANCE; ANTIVIRAL ACTIVITY; ETHANOLIC EXTRACT;
   N-ACETYLCYSTEINE; RED PROPOLIS; ANTIOXIDANT
AB Propolis is a mass of chemically diverse phytoconstituents with gummy textures that are naturally produced by honeybees upon collection of plant resins for utilization in various life processes in beehives. Since ancient times, propolis has been a unique traditional remedy globally utilized for several purposes, and it has secured value in pharmaceutical and nutraceutical areas in recent years. The chemical composition of propolis comprises diverse constituents and deviations in the precise composition of the honeybee species, plant source used for propolis production by bees, climate conditions and harvesting season. Over 300 molecular structures have been discovered from propolis, and important classes include phenolic acids, flavonoids, terpenoids, benzofurans, benzopyrene and chalcones. Propolis has also been reported to have diverse pharmacological activities, such as antidiabetic, anti-inflammatory, antioxidant, anticancer, immunomodulatory, antibacterial, antiviral, antifungal, and anticaries. As chronic diseases have risen as a global health threat, abundant research has been conducted to track propolis and its constituents as alternative therapies for chronic diseases. Several clinical trials have also revealed the potency of propolis and its constituents for preventing and curing some chronic diseases. This review explores the beneficial effect of propolis and its active constituents with credible mechanisms and computational studies on chronic diseases.
C1 [Chavda, Vivek P.] LM Coll Pharm, Dept Pharmaceut & Pharmaceut Technol, Ahmadabad 380008, India.
   [Chaudhari, Amit Z.; Teli, Divya] LM Coll Pharm, Dept Pharmaceut Chem, Ahmadabad 380009, India.
   [Balar, Pankti] LM Coll Pharm, Pharm Sect, Ahmadabad 380009, India.
   [Vora, Lalitkumar] Queens Univ Belfast, Sch Pharm, 97 Lisburn Rd, Belfast BT9 7BL, North Ireland.
C3 Queens University Belfast
RP Chavda, VP (corresponding author), LM Coll Pharm, Dept Pharmaceut & Pharmaceut Technol, Ahmadabad 380008, India.; Vora, L (corresponding author), Queens Univ Belfast, Sch Pharm, 97 Lisburn Rd, Belfast BT9 7BL, North Ireland.
EM vivek.chavda@lmcp.ac.in; l.vora@qub.ac.uk
RI Chaudhari, Amit/JSK-6084-2023; Balar, Pankti/HTS-1474-2023; VORA,
   LALITKUMAR/ABA-7080-2020; Chavda, Vivek/ADR-8736-2022
OI Vora, Dr. Lalitkumar K./0000-0001-8106-9066; Chavda,
   Vivek/0000-0002-7701-8597; Chaudhari, Amit/0009-0000-1674-5427
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NR 128
TC 22
Z9 24
U1 3
U2 19
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2227-9059
J9 BIOMEDICINES
JI Biomedicines
PD FEB
PY 2023
VL 11
IS 2
AR 259
DI 10.3390/biomedicines11020259
PG 24
WC Biochemistry & Molecular Biology; Medicine, Research & Experimental;
   Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Research & Experimental Medicine;
   Pharmacology & Pharmacy
GA 9G6TO
UT WOS:000938283100001
PM 36830794
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Wu, X
   Liu, GD
   Zhang, YY
   Zhang, W
   Dai, YT
   Jiang, H
   Zhang, XS
AF Wu, Xu
   Liu, Guodong
   Zhang, Yuyang
   Zhang, Wei
   Dai, Yutian
   Jiang, Hui
   Zhang, Xiansheng
TI The association between uric acid and erectile dysfunction: A systematic
   review and Meta-analysis
SO ANDROLOGIA
LA English
DT Review
DE erectile dysfunction; meta-analysis; systematic review; uric acid
ID MUSCLE-CELL PROLIFERATION; CORONARY-ARTERY-DISEASE; ENDOTHELIAL
   DYSFUNCTION; CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; OXIDATIVE
   STRESS; NITRIC-OXIDE; ALLOPURINOL; MEN; HYPERURICEMIA
AB The main purpose of this systematic review and meta-analysis was to explore the association between uric acid (UA) and erectile dysfunction (ED). Databases including PubMed, Cochrane Library and Web of Science were retrieved to identify studies published in English up to 31 June 2021. We preregistered this meta-analysis in the PROSPERO (registration number CRD42021267035). Two independent authors extracted the relevant data from all enrolled articles. We evaluated the quality of enrolled studies using the Newcastle-Ottawa Scale (NOS). The standardized mean difference (SMD), as well as the corresponding 95% confidence intervals (95% CIs), was used to assess the difference between ED patients and healthy subjects. A total of five studies were enrolled for our meta-analysis to explore the association of UA with ED. The pooled SMD of the UA level difference between ED patients and healthy subjects was 0.42 (95% CI:0.09, 0.74, p < 0.001). There were no individual data that significantly influenced the pooled SMDs in the sensitivity analysis. There was no evidence of publication bias. This novel meta-analysis confirmed that UA was an independent risk factor for ED, which suggested that the erectile function of patients with elevated uric acid should be evaluated by clinicians.
C1 [Wu, Xu; Liu, Guodong; Zhang, Yuyang; Zhang, Wei; Zhang, Xiansheng] Anhui Med Univ, Affiliated Hosp 1, Dept Urol, Hefei, Peoples R China.
   [Dai, Yutian] Nanjing Univ, Sch Med, Drum Tower Hosp, Dept Androl, Nanjing, Peoples R China.
   [Jiang, Hui] Peking Univ Third Hosp, Dept Urol, Beijing, Peoples R China.
C3 Anhui Medical University; Nanjing University; Peking University
RP Dai, YT (corresponding author), Nanjing Univ, Sch Med, Drum Tower Hosp, Dept Androl, Nanjing, Peoples R China.; Jiang, H (corresponding author), Peking Univ Third Hosp, Dept Urol, Beijing, Peoples R China.; Zhang, XS (corresponding author), Anhui Med Univ, Affiliated Hosp 1, Hefei, Anhui, Peoples R China.
EM 13913957628@163.com; jianghui55@163.com; xiansheng-zhang@163.com
RI jiang, hui/KYP-5273-2024
OI Zhang, Yuyang/0000-0002-0462-2574; wu, xu/0000-0003-2130-1980
FU National Natural Science Foundation of China [8207061072]
FX This work received funding from the National Natural Science Foundation
   of China (Grant No. 8207061072)
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NR 53
TC 5
Z9 5
U1 0
U2 10
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0303-4569
EI 1439-0272
J9 ANDROLOGIA
JI Andrologia
PD APR
PY 2022
VL 54
IS 3
AR e14319
DI 10.1111/and.14319
EA NOV 2021
PG 11
WC Andrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA ZO6HA
UT WOS:000720141900001
PM 34796510
OA gold
DA 2025-06-11
ER

PT J
AU Aghdam, SD
   Siassi, F
   Esfahani, EN
   Qorbani, M
   Rajab, A
   Sajjadpour, Z
   Bashiri, A
   Aghayan, M
   Sotoudeh, G
AF Aghdam, Saeideh Delshad
   Siassi, Fereydoun
   Esfahani, Ensieh Nasli
   Qorbani, Mostafa
   Rajab, Asadollah
   Sajjadpour, Zahra
   Bashiri, Anahita
   Aghayan, Maryam
   Sotoudeh, Gity
TI Dietary phytochemical index associated with cardiovascular risk factor
   in patients with type 1 diabetes mellitus
SO BMC CARDIOVASCULAR DISORDERS
LA English
DT Article
DE Diabetes mellitus; cardiovascular diseases; phytochemicals; adult;
   hyperglycemia
ID FASTING BLOOD-GLUCOSE; OXIDATIVE STRESS; LIPID PROFILE; METABOLIC
   SYNDROME; POLYPHENOLS; PRESSURE; NUTRACEUTICALS; METAANALYSIS;
   CONSUMPTION; OVERWEIGHT
AB Background Dietary phytochemical index (DPI) is useful and inexpensive method to identify the role of phytochemicals on cardiovascular disease (CVD) risk factors. This study aimed to assess the relationship between DPI and CVD risk factors in patients with type1 diabetes mellitus. Methods
   A total of 261 participants aged 18-35 years with T1DM were enrolled in this cross-sectional study to assess the relationship between DPI and CVD risk factors. Anthropometric measurements, blood lipids, glucose, and antioxidant level were measured. Food intakes were determined using a food frequency questionnaire to calculate DPI. Logistic regression was used. Results The mean age of participants was 25 years. After adjustment for potential confounders, participants in the highest tertile of DPI had 88 % lower chance of hyperglycemia (P for trend = 0.020), 81 % lower chance of low high-density lipoprotein cholesterol (HDL-C) (P for trend = 0.030) and 98 % lower chance of high low-density lipoprotein cholesterol to HDL-C ratio (P for tend = 0.040). There were no relationships between DPI and other CVD risk factors. Conclusions Although higher intake of phytochemical-rich foods had a beneficial effect on some risk factors of CVD, more studies more studies are warranted to corroborate the present findings.
C1 [Aghdam, Saeideh Delshad; Siassi, Fereydoun; Sajjadpour, Zahra; Bashiri, Anahita; Sotoudeh, Gity] Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Community Nutr, Hojatdost St,Naderi St, Tehran 1416753955, Iran.
   [Esfahani, Ensieh Nasli] Univ Tehran Med Sci, Diabet Res Ctr, Endocrinol & Metab Clin Sci Inst, Tehran, Iran.
   [Qorbani, Mostafa] Alborz Univ Med Sci, Noncommunicable Dis Res Ctr, Karaj, Iran.
   [Qorbani, Mostafa] Univ Tehran Med Sci, Chron Dis Res Ctr, Endocrinol & Metab Populat Sci Inst, Tehran, Iran.
   [Rajab, Asadollah] Iranian Diabet Assoc, Tehran, Iran.
   [Aghayan, Maryam] Shahid Beheshti Univ Med Sci, Nutr & Endocrine Res Ctr, Res Inst Endocrine Sci, Tehran, Iran.
C3 Tehran University of Medical Sciences; Tehran University of Medical
   Sciences; Alborz University of Medical Sciences; Tehran University of
   Medical Sciences; Shahid Beheshti University Medical Sciences
RP Siassi, F; Sotoudeh, G (corresponding author), Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Community Nutr, Hojatdost St,Naderi St, Tehran 1416753955, Iran.
EM siassif@tums.ac.ir; gsotodeh@tums.ac.ir
RI aghayan, maryam/AAA-9778-2020; Sotoudeh, Gity/E-3973-2018; Qorbani,
   Mostafa/M-8171-2017
OI Aghayan, Maryam/0000-0001-6768-0213
FU International Campus of Tehran University of Medical Sciences (TUMS)
   [94-03-103-30046]
FX This research was supported by International Campus of Tehran University
   of Medical Sciences (TUMS) (Grant No. 94-03-103-30046).
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NR 47
TC 18
Z9 18
U1 0
U2 8
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1471-2261
J9 BMC CARDIOVASC DISOR
JI BMC Cardiovasc. Disord.
PD JUN 12
PY 2021
VL 21
IS 1
AR 293
DI 10.1186/s12872-021-02106-2
PG 11
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA SU3FO
UT WOS:000663026500001
PM 34118879
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Rajamani, A
   Borkowski, K
   Akre, S
   Fernandez, A
   Newman, JW
   Simon, S
   Passerini, AG
AF Rajamani, Anita
   Borkowski, Kamil
   Akre, Samir
   Fernandez, Andrea
   Newman, John W.
   Simon, Scott, I
   Passerini, Anthony G.
TI Oxylipins in triglyceride-rich lipoproteins of dyslipidemic subjects
   promote endothelial inflammation following a high fat meal
SO SCIENTIFIC REPORTS
LA English
DT Article
ID SOLUBLE EPOXIDE HYDROLASE; ENDOPLASMIC-RETICULUM STRESS;
   CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; ACID; CHOLESTEROL;
   INHIBITION; VCAM-1; PLASMA; RISK
AB Elevated trig lyceride-rich lipoproteins (TGRL) in circulation is a risk factor for atherosclerosis. TGRL from subjects consuming a high saturated fat test meal elicited a variable inflammatory response in TNF alpha-stimulated endothelial cells (EC) that correlated strongly with the polyunsaturated fatty acid (PUFA) content. This study investigates how the relative abundance of oxygenated metabolites of PUFA, oxylipins, is altered in TGRL postprandially, and how these changes promote endothelial inflammation. Human aortic EC were stimulated with TNF alpha and treated with TGRL, isolated from subjects' plasma at fasting and 3.5 hrs postprandial to a test meal high in saturated fat. Endothelial VCAM-1 surface expression stimulated by TNF alpha provided a readout for atherogenic inflammation. Concentrations of esterified and non-esterified fatty acids and oxylipins in TGRL were quantified by mass spectrometry. Dyslipidemic subjects produced TGRL that increased endothelial VCAM-1 expression by >= 35%, and exhibited impaired fasting lipogenesis activity and a shift in soluble epoxide hydrolase and lipoxygenase activity. Pro-atherogenicTGRL were enriched in eicosapentaenoic acid metabolites and depleted in esterified C18-PUFA-derived diols. Abundance of these metabolites was strongly predictive ofVCAM-1 expression. We conclude the altered metabolism in dyslipidemic subjects produces TGRL with a unique oxylipin signature that promotes a pro-atherogenic endothelial phenotype.
C1 [Rajamani, Anita; Akre, Samir; Fernandez, Andrea; Simon, Scott, I; Passerini, Anthony G.] Univ Calif Davis, Dept Biomed Engn, 451 Hlth Sci Dr, Davis, CA 95616 USA.
   [Borkowski, Kamil; Newman, John W.] Univ Calif Davis, West Coast Metabol Ctr, Genome Ctr, 451 Hlth Sci Dr, Davis, CA 95616 USA.
   [Newman, John W.] Univ Calif Davis, Dept Nutr, 3135 Meyer Hall,One Shields Ave, Davis, CA 95616 USA.
   [Newman, John W.] ARS, Western Human Nutr Res Ctr, Obes & Metab Res Unit, USDA, 430 West Hlth Sci Dr, Davis, CA 95616 USA.
C3 University of California System; University of California Davis;
   University of California System; University of California Davis;
   University of California System; University of California Davis; United
   States Department of Agriculture (USDA)
RP Passerini, AG (corresponding author), Univ Calif Davis, Dept Biomed Engn, 451 Hlth Sci Dr, Davis, CA 95616 USA.
EM agpasserini@ucdavis.edu
RI Akre, Samir/AAH-9189-2021
OI Passerini, Anthony/0000-0001-8007-4672; Akre-Bhide,
   Samir/0000-0003-1495-6399; Newman, John/0000-0001-9632-6571
FU National Institute of Health (NIH) [HL082689]; NIH [DK097154]; USDA
   Intramural Project [2032-51530-022-00D]
FX This study was supported by National Institute of Health (NIH) grant
   HL082689 (S.I.S. and A.G.P.). Partial support of metabolomics profiling
   was provided by NIH DK097154, and USDA Intramural Project
   2032-51530-022-00D (J.W.N). The USDA is an equal opportunity employer
   and provider. Methyl esters of representative oxylipins were synthesized
   by Bogdan Barnych of the Bruce Hammock Lab (UC Davis). The content is
   solely the responsibility of the authors and does not necessarily
   represent the official views of the National Institutes of Health.
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NR 52
TC 18
Z9 22
U1 0
U2 6
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD JUN 17
PY 2019
VL 9
AR 8655
DI 10.1038/s41598-019-45005-5
PG 17
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA ID6AY
UT WOS:000471760200003
PM 31209255
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Levy, E
   Spahis, S
   Bigras, JL
   Delvin, E
   Borys, JM
AF Levy, Emile
   Spahis, Schohraya
   Bigras, Jean-Luc
   Delvin, Edgard
   Borys, Jean-Michel
TI The Epigenetic Machinery in Vascular Dysfunction and Hypertension
SO CURRENT HYPERTENSION REPORTS
LA English
DT Review
DE Hypertension; Epigenetics; MicroRNAs; Angiogenesis; DNA methylation;
   Regulation of blood pressure
ID PULMONARY ARTERIAL-HYPERTENSION; BLOOD-PRESSURE REGULATION; NITRIC-OXIDE
   SYNTHASE; DNA METHYLATION; DIFFERENTIAL EXPRESSION; OXIDATIVE STRESS;
   ANGIOTENSIN-II; ENDOTHELIAL-CELLS; MONONUCLEAR-CELLS; GENE-EXPRESSION
AB Hypertension (HT) is among the major components of the metabolic syndrome, i.e., obesity, dyslipidemia, and hyperglycemia/insulin resistance. It represents a significant health problem with foremost risks for chronic cardiovascular disease and a significant cause of morbidity and mortality worldwide. Therefore, it is not surprising that this disorder constitutes a serious public health concern. Although multiple studies have stressed the multifactorial nature of HT, the pathogenesis remains largely unknown. However, if we want to reduce the global prevalence of HT, restrain the number of deaths (currently 9.4 million/year in the world), and alleviate the socio-economic burden, a deeper insight into the mechanisms is urgently needed in order to define new meaningful therapeutic targets. Recently, the role of epigenetics in the development of various complex diseases has attracted much attention. In the present review, we provide a critical update on the available literature and ongoing research regarding the epigenetic modifications of genes involved in several pathways of elevated blood pressure, especially those linked to the vascular epithelium. This review also focuses on the role of microRNA (miRNA) in the regulation of gene expression associated with HT and of fetal programming mediating susceptibility to HT in adulthood.
C1 [Levy, Emile; Spahis, Schohraya; Bigras, Jean-Luc; Delvin, Edgard] St Justine Hosp, Hlth Ctr, Res Ctr, Montreal, PQ H3T 1C5, Canada.
   [Levy, Emile; Spahis, Schohraya] Univ Montreal, Dept Nutr, Montreal, PQ H3C 3J7, Canada.
   [Levy, Emile; Spahis, Schohraya] Laval Univ, Inst Nutr & Funct Foods, Quebec City, PQ G1V 0A6, Canada.
   [Levy, Emile; Borys, Jean-Michel] EPODE Int Network, Paris, France.
   [Levy, Emile] St Justine Univ Hosp, Hlth Ctr, GI Nutr Unit, 3175 Ste Catherine Rd, Montreal, PQ H3T 1C5, Canada.
C3 Universite de Montreal; Centre Hospitalier Universitaire Sainte-Justine;
   Universite de Montreal; Laval University; Universite de Montreal
RP Levy, E (corresponding author), St Justine Hosp, Hlth Ctr, Res Ctr, Montreal, PQ H3T 1C5, Canada.; Levy, E (corresponding author), Univ Montreal, Dept Nutr, Montreal, PQ H3C 3J7, Canada.; Levy, E (corresponding author), Laval Univ, Inst Nutr & Funct Foods, Quebec City, PQ G1V 0A6, Canada.; Levy, E (corresponding author), EPODE Int Network, Paris, France.; Levy, E (corresponding author), St Justine Univ Hosp, Hlth Ctr, GI Nutr Unit, 3175 Ste Catherine Rd, Montreal, PQ H3T 1C5, Canada.
EM emile.levy@recherche-ste-justine.qc.ca
FU J.A. deSeve Research Chair in Nutrition
FX The current work was supported by the J.A. deSeve Research Chair in
   Nutrition.
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NR 107
TC 34
Z9 36
U1 0
U2 17
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1522-6417
EI 1534-3111
J9 CURR HYPERTENS REP
JI Curr. Hypertens. Rep.
PD JUN
PY 2017
VL 19
IS 6
AR 52
DI 10.1007/s11906-017-0745-y
PG 12
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA EW8KI
UT WOS:000402767200008
PM 28540644
DA 2025-06-11
ER

PT J
AU Moriishi, K
AF Moriishi, Kohji
TI The potential of signal peptide peptidase as a therapeutic target for
   hepatitis C
SO EXPERT OPINION ON THERAPEUTIC TARGETS
LA English
DT Review
DE HCV; signal peptide peptidase; hepatitis C; DAA
ID VIRUS CORE PROTEIN; REGULATED INTRAMEMBRANE PROTEOLYSIS;
   GAMMA-SECRETASE; PRECURSOR PROTEIN; IN-VITRO; ALZHEIMERS-DISEASE;
   INSULIN-RESISTANCE; HUMAN HEPATOCYTES; OXIDATIVE STRESS; RNA REPLICATION
AB Introduction: Chronic infection with hepatitis C virus (HCV) causes liver steatosis, cirrhosis, metabolic syndrome with inflammation, and eventually leads to hepatocellular carcinoma. HCV core protein is a well-known capsid protein and pathogenic factor related to lipid accumulation, type 2 diabetes mellitus, and carcinogenesis. Cleavage of the C-terminal transmembrane region by signal peptide peptidase (SPP) is required for maturation of the core protein.
   Areas covered: Herein, this review details the general aspects of the structure, lifecycle, pathogenesis, and maturation of the HCV core protein, the function of SPP, and clinically available direct-acting antivirals (DAAs). SPP is classified into a group of GXGD-type intramembrane proteases including presenilin-1, which is a component of.-secretase complex. Several SPP inhibitors were previously identified from.-secretase inhibitors, but have not yet been improved based on specificity to SPP. Finally, the author discusses the potential of SPP inhibitors for hepatitis C therapy.
   Expert opinion: Currently available DAAs therapies are limited because of different viral genotypes and underlying conditions in each patient. DAA-resistant viruses have also been reported. Development of SPP-selective inhibitors may improve current HCV therapies by decreasing in the emergence of DAA-resistant viruses irrespective of viral genotype.
C1 [Moriishi, Kohji] Univ Yamanashi, Grad Sch Med Sci, Dept Microbiol, Chuo, Yamanashi, Japan.
C3 University of Yamanashi
RP Moriishi, K (corresponding author), Univ Yamanashi, Grad Sch Med & Engn, Dept Microbiol, Div Med, 1110 Shimokato, Chuo, Yamanashi 4093898, Japan.
EM kmoriishi@yamanashi.ac.jp
RI Moriishi, Kohji/I-4173-2019
OI Moriishi, Kohji/0000-0002-9542-5188
FU Japan Agency for Medical Research and Development [16fk0210109h1301,
   16fk0210106h0001]; JSPS KAKENHI [JP15k08439]
FX This review is supported by Grants-in-Aids from Research Programs on
   Hepatitis from the Japan Agency for Medical Research and Development
   (16fk0210109h1301 and 16fk0210106h0001) and from JSPS KAKENHI grant No.
   JP15k08439.
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NR 133
TC 6
Z9 6
U1 0
U2 2
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1472-8222
EI 1744-7631
J9 EXPERT OPIN THER TAR
JI Expert Opin. Ther. Targets
PY 2017
VL 21
IS 9
BP 827
EP 836
DI 10.1080/14728222.2017.1369959
PG 10
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA FE6XK
UT WOS:000408352000001
PM 28820612
DA 2025-06-11
ER

PT J
AU Porto, LCS
   da Silva, J
   Ferraz, ADF
   Corrêa, DS
   dos Santos, MS
   Porto, CD
   Picada, JN
AF Santos Porto, Luiz Carlos
   da Silva, Juliana
   Falcao Ferraz, Alexandre de Barros
   Correa, Dione Silva
   dos Santos, Marcela Silva
   Porto, Caroline Dalla Lana
   Picada, Jaqueline Nascimento
TI Evaluation of acute and subacute toxicity and mutagenic activity of the
   aqueous extract of pecan shells [Carya illinoinensis (Wangenh.)
   K. Koch]
SO FOOD AND CHEMICAL TOXICOLOGY
LA English
DT Article
DE Carya illinoinensis; Pecan shell; Micronucleus test;
   Salmonella/microsome assay; Gallic acid; Ellagic acid
ID GALLIC ACID; METABOLIC SYNDROME; OXIDATIVE STRESS; NUT SHELLS;
   BY-PRODUCT; ANTIOXIDANT; PROFILES
AB The infusion of pecan shells has been used to prevent and control hypercholesterolemia, diabetes and toxicological diseases. The aim of the present study was to evaluate toxicity and mutagenic effects of pecan shells aqueous extract (PSAE). Wistar rats were treated with a single dose of 300 or 2000 mg/kg of PSAE in the acute toxicity test. For the subacute test, the animals received 10 or 100 mg/kg of PSAE for 28 days. The mutagenicity was evaluated using Salmonella/microsome assay in TA1535, TA1537, TA98, TA100 and TA102 S. typhimurium strains in the presence and absence of metabolic activation (S9 mix) and micronucleus test in bone marrow. HPLC analyses indicated the presence of tannins, flavonoids, gallic and ellagic acids. Except for triglycerides, all treated groups presented normal hematological and biochemical parameters. Lower levels of triglycerides and weight loss were observed in the 100 mg/kg group. Mutagenic activities were not detected in S. typhimurium strains and by the micronucleus test. Based on these results, PSAE was not able to induce chromosomal or point mutations, under the conditions tested. The 100 mg/kg dose showed significant antihyperlipidemic action, with no severe toxic effects. (C) 2013 Elsevier Ltd. All rights reserved.
C1 [Santos Porto, Luiz Carlos] Univ Regiao Campanha URCAMP, BR-97670000 Sao Borja, RS, Brazil.
   [Santos Porto, Luiz Carlos; da Silva, Juliana; Picada, Jaqueline Nascimento] Univ Luterana Brasil ULBRA, Lab Genet Toxicol, BR-92425900 Canoas, RS, Brazil.
   [Falcao Ferraz, Alexandre de Barros; Correa, Dione Silva; dos Santos, Marcela Silva] Univ Luterana Brasil ULBRA, Lab Fitoquim, BR-92425900 Canoas, RS, Brazil.
   [Porto, Caroline Dalla Lana] URI, BR-98802470 Santo Angelo, RS, Brazil.
C3 Universidade Luterana do Brasil; Universidade Luterana do Brasil;
   Universidade Regional Integrada do Alto Uruguai e das Missoes (URI)
RP Picada, JN (corresponding author), Univ Luterana Brasil, Lab Genet Toxicol, Ave Farroupilha 8001, BR-92425900 Canoas, RS, Brazil.
EM jnpicada@cpovo.net
RI Ferraz, Alexandre/AAG-9661-2019; Picada, Jaqueline/B-2480-2014; dos
   Santos, Marcela/O-2100-2015; Silva Correa, Dione/AAJ-2851-2021; da
   Silva, Juliana/J-8996-2012
OI Silva Correa, Dione/0000-0003-4876-8302; da Silva,
   Juliana/0000-0002-1089-6766; Ferraz, Alexandre/0000-0003-2665-5200
FU CNPq (Conselho Nacional de Desenvolvimento Cientifico e Tecnologico);
   FAPERGS (Fundacao de Amparo a Pesquisa do Estado do Rio Grande do Sul),
   Brazil
FX This work was supported by CNPq (Conselho Nacional de Desenvolvimento
   Cientifico e Tecnologico) and FAPERGS (Fundacao de Amparo a Pesquisa do
   Estado do Rio Grande do Sul), Brazil. The authors are grateful to
   Pecanita Agroindustrial Ltda. (Cachoeira do Sul, RS, Brazil) for his
   donation of pecan shells.
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NR 41
TC 18
Z9 19
U1 0
U2 16
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0278-6915
EI 1873-6351
J9 FOOD CHEM TOXICOL
JI Food Chem. Toxicol.
PD SEP
PY 2013
VL 59
BP 579
EP 585
DI 10.1016/j.fct.2013.06.048
PG 7
WC Food Science & Technology; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Toxicology
GA 216JR
UT WOS:000324280000073
PM 23831307
DA 2025-06-11
ER

PT J
AU Pinent, M
   Cedó, L
   Montagut, G
   Blay, M
   Ardévol, A
AF Pinent, Montserrat
   Cedo, Lidia
   Montagut, Gemma
   Blay, Mayte
   Ardevol, Anna
TI Procyanidins Improve some Disrupted Glucose Homoeostatic Situations: An
   Analysis of Doses and Treatments According to Different Animal Models
SO CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
LA English
DT Review
DE procyanidin; glucose; diabetes; insulin resistance; human studies; rat
ID GRAPE SEED PROANTHOCYANIDINS; GREEN TEA POLYPHENOL; PINE BARK EXTRACT;
   REDUCES BLOOD-PRESSURE; OXIDATIVE STRESS; INSULIN-RESISTANCE; METABOLIC
   SYNDROME; ENDOTHELIAL FUNCTION; IN-VIVO; CARDIOVASCULAR RISK
AB This review analyses the potential beneficial effects of procyanidins, the main class of flavonoids, in situations in which glucose homeostasis is disrupted. Because the disruption of glucose homeostasis can occur as a result of various causes, we critically review the effects of procyanidins based on the specific origin of each type of disruption. Where little or no insulin is present (Type I diabetic animals), summarized studies of procyanidin treatment suggest that procyanidins have a short-lived insulin-mimetic effect on the internal targets of the organism, an effect not reproduced in normoglycemic, normoinsulinemic healthy animals. Insulin resistance (usually linked to hyperinsulinemia) poses a very different situation. Preventive studies using fructose-fed models indicate that procyanidins may be useful in preventing the induction of damage and thus in limiting hyperglycemia. But the results of other studies using models such as high-fat diet treated rats or genetically obese animals are controversial. Although the effects on glucose parameters are hazy, it is known that procyanidins target key tissues involved in its homeostasis. Interestingly, all available data suggest that procyanidins are more effective when administered in one acute load than when mixed with food.
C1 [Pinent, Montserrat; Cedo, Lidia; Montagut, Gemma; Blay, Mayte; Ardevol, Anna] Univ Rovira & Virgili URV, Dept Bioquim & Biotecnol, Tarragona 43007, Spain.
C3 Universitat Rovira i Virgili
RP Ardévol, A (corresponding author), Univ Rovira & Virgili URV, Dept Bioquim & Biotecnol, C Marcel Li Domingo S-N, Tarragona 43007, Spain.
EM anna.ardevol@urv.cat
RI Ardévol, Anna/AAO-6194-2021; Pinent, Montserrat/C-7109-2011; Blay, M.
   Teresa/B-1680-2009; Cedo Gine, Lidia/ABG-1998-2020
OI Ardevol, Anna/0000-0003-0156-7538; Montagut Pino,
   Gemma/0000-0001-8954-0449; Pinent, Montserrat/0000-0003-3550-5378; Blay,
   M. Teresa/0000-0002-6256-9847; Cedo Gine, Lidia/0000-0003-4354-3411
FU Spanish Government [AGL2008-01310, AGL2008-00387]; Universitat Rovira i
   Virgili in Tarragona; Generalitat de Catalunya
FX This studywas supported by grant numbers AGL2008-01310 and AGL2008-00387
   from the Spanish Government. Gemma Montagut received a fellowship from
   Universitat Rovira i Virgili in Tarragona. Lidia Cedo received a
   fellowship from the Generalitat de Catalunya. We would also like to
   thank the Language Service of the Universitat Rovira i Virgili for
   revising this manuscript.
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NR 94
TC 46
Z9 48
U1 1
U2 42
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1040-8398
EI 1549-7852
J9 CRIT REV FOOD SCI
JI Crit. Rev. Food Sci. Nutr.
PY 2012
VL 52
IS 7
BP 569
EP 584
DI 10.1080/10408398.2010.501533
PG 16
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA 944AI
UT WOS:000304170000001
PM 22530710
DA 2025-06-11
ER

PT J
AU Martinelli, I
   Tomassoni, D
   Roy, P
   Amenta, F
   Tayebati, SK
AF Martinelli, Ilenia
   Tomassoni, Daniele
   Roy, Proshanta
   Amenta, Francesco
   Tayebati, Seyed Khosrow
TI Altered Brain Cholinergic and Synaptic Markers in Obese Zucker Rats
SO CELLS
LA English
DT Article
DE brain; cholinergic system; synaptic transmission; metabolic syndrome;
   obesity
ID VESICULAR ACETYLCHOLINE TRANSPORTER; HIGH-FAT-DIET; ALPHA-7 NICOTINIC
   RECEPTOR; OXIDATIVE STRESS; COGNITIVE IMPAIRMENT; MUSCARINIC RECEPTORS;
   INSULIN SENSITIVITY; ALZHEIMERS-DISEASE; ACTIVATION; NEUROINFLAMMATION
AB The association between obesity and loss of cognitive performance has been recognized. Although there are data regarding the metabolic alterations in obese conditions and the development of neuroinflammation, no clear evidence concerning obesity-related cholinergic and synaptic impairments in the frontal cortex and hippocampus has been reported yet. Here, we investigate different cholinergic and synaptic markers in 12-, 16-, and 20-week-old obese Zucker rats (OZRs) compared with lean littermate rats (LZRs), using immunochemical and immunohistochemical analysis. Consequently, OZRs showed body weight gain, hypertension, and dysmetabolism. In 20-week-old OZRs, the reduction of vesicular acetylcholine transporter (VAChT) and alpha7 nicotinic acetylcholine receptors (alpha 7nAChR) occurred both in the frontal cortex and in the hippocampus, suggesting a cognitive dysfunction due to obesity and aging. Among the muscarinic receptors analyzed, the level of expression of type 1 (mAChR1) was lower in the hippocampus of the older OZRs. Finally, we showed synaptic dysfunctions in OZRs, with a reduction of synaptophysin (SYP) and synaptic vesicle glycoprotein 2B (SV2B) in 20-week-old OZRs, both in the frontal cortex and in the hippocampus. Taken together, our data suggest specific alterations of cholinergic and synaptic markers that can be targeted to prevent cognitive deficits related to obesity and aging.
C1 [Martinelli, Ilenia; Amenta, Francesco; Tayebati, Seyed Khosrow] Univ Camerino, Sch Pharm, I-62032 Camerino, Italy.
   [Tomassoni, Daniele; Roy, Proshanta] Univ Camerino, Sch Biosci & Vet Med, I-62032 Camerino, Italy.
C3 University of Camerino; University of Camerino
RP Tayebati, SK (corresponding author), Univ Camerino, Sch Pharm, I-62032 Camerino, Italy.
EM ilenia.martinelli@unicam.it; daniele.tomassoni@unicam.it;
   proshanta.roy@unicam.it; francesco.amenta@unicam.it;
   khosrow.tayebati@unicam.it
RI Tayebati, Seyed/AGK-8739-2022
OI Tayebati, Seyed Khosrow/0000-0002-7219-6917; Roy,
   Proshanta/0000-0001-6482-6117; Francesco, Amenta/0000-0002-0555-1034;
   Tomassoni, Daniele/0000-0001-9062-3305; MARTINELLI,
   ILENIA/0000-0002-7702-7784
FU University of Camerino, FAR-2018
FX This research was funded by the University of Camerino, FAR-2018.
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Z9 16
U1 0
U2 4
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2073-4409
J9 CELLS-BASEL
JI Cells
PD OCT
PY 2021
VL 10
IS 10
AR 2528
DI 10.3390/cells10102528
PG 16
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA WO0XC
UT WOS:000712185300001
PM 34685507
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Anwer, H
   Morris, MJ
   Noble, DWA
   Nakagawa, S
   Lagisz, M
AF Anwer, Hamza
   Morris, Margaret J.
   Noble, Daniel W. A.
   Nakagawa, Shinichi
   Lagisz, Malgorzata
TI Transgenerational effects of obesogenic diets in rodents: A
   meta-analysis
SO OBESITY REVIEWS
LA English
DT Article
DE grand-offspring; grand-parents; obesity; systematic review
ID HIGH-FAT DIET; ENDOPLASMIC-RETICULUM STRESS; HYPOTHALAMIC
   GENE-EXPRESSION; MATERNAL OBESITY; METABOLIC PHENOTYPE; LEPTIN
   RESISTANCE; BODY-WEIGHT; OFFSPRING HYPERPHAGIA; REPRODUCTIVE HEALTH;
   INSULIN-RESISTANCE
AB Obesity is a major health condition that affects millions worldwide. There is an increased interest in understanding the adverse outcomes associated with obesogenic diets. A multitude of studies have investigated the transgenerational impacts of maternal and parental obesogenic diets on subsequent generations of offspring, but results have largely been mixed. We conducted a systematic review and meta-analysis on rodent studies to elucidate how obesogenic diets impact the mean and variance of grand-offspring traits. Our study focused on transgenerational effects (i.e., F2 and F3 generations) in one-off and multigenerational exposure studies. From 33 included articles, we obtained 407 effect sizes representing pairwise comparisons of control and treatment grand-offspring groups pertaining to measures of body weight, adiposity, glucose, insulin, leptin, and triglycerides. We found evidence that male and female grand-offspring descended from grandparents exposed to an obesogenic diet displayed phenotypes consistent with metabolic syndrome, especially in cases where the obesogenic diet was continued across generations. Further, we found stronger evidence for the effects of grand-maternal than grand-paternal exposure on grand-offspring traits. A high-fat diet in one-off exposure studies did not seem to impact phenotypic variation, whereas in multigenerational exposure studies it reduced variation in several traits.
C1 [Anwer, Hamza; Noble, Daniel W. A.; Nakagawa, Shinichi; Lagisz, Malgorzata] Univ New South Wales, Evolut & Ecol Res Ctr, Sydney, NSW, Australia.
   [Anwer, Hamza; Noble, Daniel W. A.; Nakagawa, Shinichi; Lagisz, Malgorzata] Univ New South Wales, Sch Biol Earth & Environm Sci, Sydney, NSW, Australia.
   [Morris, Margaret J.] Univ New South Wales, Sch Med Sci, Sydney, NSW, Australia.
   [Noble, Daniel W. A.] Australian Natl Univ, Res Sch Biol, Div Ecol & Evolut, Canberra, ACT, Australia.
C3 University of New South Wales Sydney; University of New South Wales
   Sydney; University of New South Wales Sydney; Australian National
   University
RP Anwer, H (corresponding author), Univ New South Wales, Evolut & Ecol Res Ctr, Sch Biol Earth & Environm Sci, Sydney, NSW 2052, Australia.
EM hamza.anwer@student.unsw.edu.au
RI Lagisz, Malgorzata/A-3100-2010; Nakagawa, Shinichi/B-5571-2011; Noble,
   Daniel WA/H-6214-2013
OI Lagisz, Malgorzata/0000-0002-3993-6127; Anwer,
   Hamza/0000-0002-5380-6759; Nakagawa, Shinichi/0000-0002-7765-5182;
   Noble, Daniel WA/0000-0001-9460-8743; Morris,
   Margaret/0000-0003-2285-5117
FU Australian Research Council [DP180100818]
FX This project was funded by the Australian Research Council Discovery
   Project DP180100818 awarded to SN. We acknowledge the help of Alexander
   Aloy with screening bibliometric records. We would like to thank the
   following researchers for responding to our requests and providing us
   with additional data and information about their studies: Gitalee
   Sarker, Eryk Andreas, Natalia Harasymowicz, Thais De Castro Barbosa; and
   additional information: Tracy Bale, Donatella Gniuli, Silvia Giraudo,
   Sonia de Assis and Sandra Barbosa.
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NR 134
TC 8
Z9 9
U1 2
U2 10
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1467-7881
EI 1467-789X
J9 OBES REV
JI Obes. Rev.
PD JAN
PY 2022
VL 23
IS 1
DI 10.1111/obr.13342
EA SEP 2021
PG 17
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA XG5ZD
UT WOS:000702130000001
PM 34595817
OA Bronze
DA 2025-06-11
ER

PT J
AU La Sala, L
   Crestani, M
   Garavelli, S
   de Candia, P
   Pontiroli, AE
AF La Sala, Lucia
   Crestani, Maurizio
   Garavelli, Silvia
   de Candia, Paola
   Pontiroli, Antonio E.
TI Does microRNA Perturbation Control the Mechanisms Linking Obesity and
   Diabetes? Implications for Cardiovascular Risk
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE obesity; diabetes; T2D; CVD; atherosclerosis; inflammation; microRNA;
   metabolic syndrome; cardiovascular complications
ID MESENCHYMAL STEM-CELLS; INHIBITING PPAR-GAMMA; INSULIN-RESISTANCE;
   OXIDATIVE STRESS; GENE-EXPRESSION; NUCLEAR EXPORT; ADIPOGENIC
   DIFFERENTIATION; CIRCULATING MICRORNAS; ENDOTHELIAL-CELLS; RECIPIENT
   CELLS
AB Metabolic disorders such as obesity and type 2 diabetes (T2D) are considered the major risk factors for the development of cardiovascular diseases (CVD). Although the pathological mechanisms underlying the mutual development of obesity and T2D are difficult to define, a better understanding of the molecular aspects is of utmost importance to identify novel therapeutic targets. Recently, a class of non-coding RNAs, called microRNAs (miRNAs), are emerging as key modulators of metabolic abnormalities. There is increasing evidence supporting the role of intra- and extracellular miRNAs as determinants of the crosstalk between adipose tissues, liver, skeletal muscle and other organs, triggering the paracrine communication among different tissues. miRNAs may be considered as risk factors for CVD due to their correlation with cardiovascular events, and in particular, may be related to the most prominent risk factors. In this review, we describe the associations observed between miRNAs expression levels and the most common cardiovascular risk factors. Furthermore, we sought to depict the molecular aspect of the interplay between obesity and diabetes, investigating the role of microRNAs in the interorgan crosstalk. Finally, we discussed the fascinating hypothesis of the loss of protective factors, such as antioxidant defense systems regulated by such miRNAs.
C1 [La Sala, Lucia; de Candia, Paola] IRCCS MultiMed, Lab Cardiovasc & Dysmetab Dis, I-20138 Milan, Italy.
   [Crestani, Maurizio] Univ Milan, Dipartimento Sci Farmacol & Biomol, I-20133 Milan, Italy.
   [Garavelli, Silvia] Consiglio Nazl Ric IEOS CNR, Ist Endocrinol & Oncol Sperimentale, Lab Immunol, I-80131 Naples, Italy.
   [Pontiroli, Antonio E.] Univ Milan, Dipartimento Sci Salute, I-20142 Milan, Italy.
C3 IRCCS Multimedica; University of Milan; Consiglio Nazionale delle
   Ricerche (CNR); Istituto per Endocrinologia e Oncologia "Gaetano
   Salvatore" (IEOS-CNR); University of Milan
RP La Sala, L (corresponding author), IRCCS MultiMed, Lab Cardiovasc & Dysmetab Dis, I-20138 Milan, Italy.
EM lucia.lasala@multimedica.it; maurizio.crestani@unimi.it;
   silvia.garavelli@multimedica.it; paola.decandia@multimedica.it;
   antonio.pontiroli@unimi.it
RI Crestani, Maurizio/ABZ-7375-2022; La Sala, Lucia/A-4467-2019; pontiroli,
   antonio/AAI-5575-2020; La Sala, Lucia/Q-9969-2016; de Candia,
   Paola/HGC-8826-2022
OI La Sala, Lucia/0000-0002-7580-1377; PONTIROLI, ANTONIO
   ETTORE/0000-0002-8217-7672; Crestani, Maurizio/0000-0001-9230-1078; de
   Candia, Paola/0000-0003-4767-446X
FU Ministry of Health (Ricerca Corrente) [02364513]; Fondazione "Romeo and
   Enrica Invernizzi", Milan (Italy)
FX This research was funded by the Ministry of Health (Ricerca Corrente)
   and RF2016 (02364513) to IRCCS MultiMedica, Italy. The authors would
   like to thank Fondazione "Romeo and Enrica Invernizzi", Milan (Italy)
   for the support.
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NR 138
TC 18
Z9 18
U1 1
U2 4
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD JAN
PY 2021
VL 22
IS 1
AR 143
DI 10.3390/ijms22010143
PG 16
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA PQ0CW
UT WOS:000606220300001
PM 33375647
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Lee, SH
   Park, SG
   Kim, MJ
   Chun, H
   Cho, DY
   Hong, D
   Kim, YS
AF Lee, Soo-Hyun
   Park, Seung Geon
   Kim, Moon-Jong
   Chun, Hyejin
   Cho, Doo-Yeoun
   Hong, Doohee
   Kim, Young-Sang
TI Bowel preparation for colonoscopy may decrease the levels of
   testosterone in Korean men
SO SCIENTIFIC REPORTS
LA English
DT Article
ID ORAL SODIUM-PHOSPHATE; HORMONE-BINDING GLOBULIN; METABOLIC SYNDROME;
   OUTPATIENT COLONOSCOPY; LUTEINIZING-HORMONE; INSULIN-RESISTANCE; STRESS
   HORMONES; HYDRATION STATE; LAVAGE SOLUTION; HYPOGONADISM
AB Although colonoscopy is commonly conducted for medical check-ups in Korea, investigations for the influence of bowel preparation on various health conditions are insufficient. This cross-sectional study investigated whether bowel preparation has an influence on serum levels of testosterone. A total of 1114 men were divided into the bowel preparation group and control groups. The median total and free testosterone levels were significantly lower in the bowel preparation group (14.89 and 0.26 nmol/L, respectively) than in the control groups (15.72 and 0.28 nmol/L, respectively). The level of total testosterone significantly increased with age in the bowel preparation group (r = 0.103). The differences in the levels of total and free testosterone between the 2 groups were more prominent in younger men than in older men. In multivariate regression models, bowel preparation was independently associated with the levels of total and free testosterone. In these models, the interaction between age and bowel preparation was significant for the levels of total and free testosterone. In conclusion, bowel preparation may independently decrease the serum levels of total and free testosterone. The decline in testosterone was more evident in younger men than in older men.
C1 [Lee, Soo-Hyun; Park, Seung Geon; Kim, Moon-Jong; Chun, Hyejin; Kim, Young-Sang] CHA Univ, Dept Family Med, CHA Bundang Med Ctr, Seongnam 13496, South Korea.
   [Cho, Doo-Yeoun] CHA Univ, Dept Clin Pharmacol & Therapeut, CHA Bundang Med Ctr, Seongnam 13496, South Korea.
   [Hong, Doohee] Suwon Cent Hosp, Suwon 16391, South Korea.
C3 Pochon Cha University; Pochon Cha University
RP Kim, YS (corresponding author), CHA Univ, Dept Family Med, CHA Bundang Med Ctr, Seongnam 13496, South Korea.
EM zeroup@cha.ac.kr
RI Cho, Doo-Yeoun/E-2372-2019; Kim, Mark/HZH-8733-2023
OI Kim, Young-Sang/0000-0002-7397-5410
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NR 65
TC 2
Z9 2
U1 0
U2 0
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD MAY 8
PY 2019
VL 9
AR 7080
DI 10.1038/s41598-019-43598-5
PG 8
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA HX4LW
UT WOS:000467369200018
PM 31068639
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Kang, HY
   Choi, YK
   Jeong, YI
   Choi, KC
   Hyun, SH
   Hwang, WS
   Jeung, EB
AF Kang, Hee Young
   Choi, Young-Kwon
   Jeong, Yeon Ik
   Choi, Kyung-Chul
   Hyun, Sang-Hwan
   Hwang, Woo-Suk
   Jeung, Eui-Bae
TI Immortalization of Porcine 11β-Hydroxysteroid Dehydrogenase Type
   1-Transgenic Liver Cells Using SV40 Large T Antigen
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE pig; hepatocytes; immortalization; HSD11B1
ID BETA-HYDROXYSTEROID DEHYDROGENASE; APPARENT MINERALOCORTICOID EXCESS;
   ALPHA-FETOPROTEIN; GLUCOCORTICOID-RECEPTOR; CHROMOSOME INSTABILITY;
   DISEASE; ESTABLISHMENT; INHIBITION; METABOLISM; MECHANISM
AB Cortisol is a steroid hormone essential to the maintenance of homeostasis that is released in response to stress and low blood glucose concentration. Cortisol is converted from cortisone by 11 beta-hydroxysteroid dehydrogenase type 1 (HSD11B1). It has been reported that too much cortisol or overexpression of HSD11B1 induces obesity and the insulin resistance that accompanies metabolic syndrome in rodent adipose tissue. In our previous study, HSD11B1-transgenic (TG) fibroblasts were established, and a porcine model was generated by SCNT using those fibroblasts. Hepatocytes overexpressing HSD11B1 were obtained from livers of this porcine model and cultured in vitro. However, the primary hepatocytes were found to have a short life span or low proliferation rate. To overcome these problems, the SV40 large T antigen was transduced into primary HSD11B1-TG hepatocytes, and those cells were immortalized. Immortalized HSD11B1-TG hepatocytes showed restored morphology, more rapid proliferation rate, and more expression of HSD11B1 than primary hepatocytes. As well, these cells kept the hepatic characteristics such as gluconeogenic response to cortisone and increased expression of hepatic makers. The immortalized HSD11B1-TG hepatocytes may be useful for studying traits and potential therapeutic drugs for treatment of metabolic disorders induced by overexpression of HSD11B1.
C1 [Kang, Hee Young; Choi, Young-Kwon; Choi, Kyung-Chul; Hyun, Sang-Hwan; Jeung, Eui-Bae] Chungbuk Natl Univ, Coll Vet Med, 1 Chungdae Ro, Cheongju 28644, Chungbuk, South Korea.
   [Jeong, Yeon Ik; Hwang, Woo-Suk] Sooam Biotech Res Fdn, 64 Kyunginro, Seoul 08359, South Korea.
   [Kang, Hee Young] KRIBB, Immunotherapy Convergence Res Ctr, 125 Gwahak Ro, Daejeon 34141, South Korea.
C3 Chungbuk National University; Korea Research Institute of Bioscience &
   Biotechnology (KRIBB)
RP Jeung, EB (corresponding author), Chungbuk Natl Univ, Coll Vet Med, 1 Chungdae Ro, Cheongju 28644, Chungbuk, South Korea.
EM heeyoung.kang@daum.net; cyk901124@naver.com; youniks@sooam.org;
   kchoi@chungbuk.ac.kr; shhyun@cbu.ac.kr; hwangws@sooam.org;
   ebjeung@chungbuk.ac.kr
RI Choi, Kyung-Chul/AHC-2282-2022
OI Kang, Hee Young/0000-0002-0250-4152
FU National Research Foundation of Korea (NRF) grant of Korean government
   (MEST) [2017R1A2B2005031]
FX This work was supported by the National Research Foundation of Korea
   (NRF) grant of Korean government (MEST) (No. 2017R1A2B2005031). Thank
   you for Han-Jin Park and Hyemin Kim working in the Korea Institute of
   Toxicology for providing the albumin antibody.
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NR 39
TC 6
Z9 6
U1 1
U2 9
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD DEC
PY 2017
VL 18
IS 12
AR 2625
DI 10.3390/ijms18122625
PG 12
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA FR2KU
UT WOS:000418896700129
PM 29206210
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Stefanon, B
   Colitti, M
AF Stefanon, Bruno
   Colitti, Monica
TI Original Research: Hydroxytyrosol, an ingredient of olive oil, reduces
   triglyceride accumulation and promotes lipolysis in human primary
   visceral adipocytes during differentiation
SO EXPERIMENTAL BIOLOGY AND MEDICINE
LA English
DT Article
DE Human visceral adipocytes; differentiation; gene expression; lipolysis;
   apoptosis; hydroxytyrosol
ID GENE-EXPRESSION; TRANSCRIPTION FACTORS; ADIPOGENESIS; ACTIVATION;
   EXTRACT; INHIBITION; FAMILY; CELLS; SIRT1; MMP-9
AB Hydroxytyrosol has various pharmacological properties, including anti-oxidative stress and anti-inflammatory activities, preventing hyperglycemia, insulin resistance, and the metabolic syndrome. The present study is focused on the anti-adipogenic and lipolytic activity of hydroxytyrosol on primary human visceral adipocytes. Pre-adipocytes were analyzed after 10 (P10) and 20 (P20) days of treatment during differentiation and after 7 (A7) days of treatment when they reached mature shape. The treatment with hydroxytyrosol extract significantly (P<0.001) increased apoptosis in P10 and P20 cells in comparison to control and A7 cells; significantly (P<0.001) reduced triglyceride accumulation in P20 cells compared to P10 and control cells; and significantly (P<0.001) increased lipolysis in P20 cells in comparison to control cells and A7 mature adipocytes. Hydroxytyrosol-treated P20 cells significantly (P<0.05) increased expression of genes involved in inhibition of adipogenesis, such as GATA2, GATA3, WNT3A, SFRP5, HES1, and SIRT1. In contrast, genes involved in promoting adipogenesis such as LEP, FGF1, CCND1, and SREBF1 were significantly down-regulated by hydroxytyrosol treatment. These data suggest that hydroxytyrosol promotes lipolysis and apoptotic activity in primary human visceral pre-adipocytes during differentiation and does not affect already mature adipocytes.
C1 [Stefanon, Bruno; Colitti, Monica] Univ Udine, Dept Sci Agroalimentari Ambientali & Anim, I-33100 Udine, Italy.
C3 University of Udine
RP Colitti, M (corresponding author), Univ Udine, Dept Sci Agroalimentari Ambientali & Anim, I-33100 Udine, Italy.
EM monica.colitti@uniud.it
RI Stefanon, Bruno/J-1820-2019
OI stefanon, bruno/0000-0002-7414-5830; colitti, monica/0000-0002-1775-3880
FU Progetto ART, Italy [13 D.LGS 297/99]
FX This work was supported by Progetto ART. 13 D.LGS 297/99, Italy.
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NR 39
TC 30
Z9 34
U1 0
U2 15
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1535-3702
EI 1535-3699
J9 EXP BIOL MED
JI Exp. Biol. Med.
PD OCT
PY 2016
VL 241
IS 16
BP 1796
EP 1802
DI 10.1177/1535370216654226
PG 7
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA DW1YF
UT WOS:000383439000010
PM 27287014
OA Green Published
DA 2025-06-11
ER

PT J
AU Nam, SM
   Kim, JW
   Yoo, DY
   Kim, W
   Jung, HY
   Hwang, IK
   Seong, JK
   Yoon, YS
AF Nam, Sung Min
   Kim, Jong Whi
   Yoo, Dae Young
   Kim, Woosuk
   Jung, Hyo Young
   Hwang, In Koo
   Seong, Je Kyung
   Yoon, Yeo Sung
TI Additive or Synergistic Effects of Aluminum on the Reduction of Neural
   Stem Cells, Cell Proliferation, and Neuroblast Differentiation in the
   Dentate Gyrus of High-Fat Diet-Fed Mice
SO BIOLOGICAL TRACE ELEMENT RESEARCH
LA English
DT Article
DE Aluminum; High-fat diet; Hippocampus; Adult neurogenesis
ID TRANSGENIC MOUSE MODEL; ALZHEIMERS-DISEASE; OXIDATIVE STRESS; COGNITIVE
   IMPAIRMENT; METABOLIC SYNDROME; VASCULAR DEMENTIA; DRINKING-WATER;
   TOXICITY; NEUROGENESIS; BRAIN
AB Aluminum is the most plentiful metal on the Earth's crust, and its usage in cooking utensils, cosmetics, drinking containers, food additives, pharmaceutical products, and building materials provides many opportunities for potential aluminum consumption. However, its toxicity is low and harmful effects only develop with large-scale deposition of aluminum. In this study, we investigated the effects of sub-chronic exposure to aluminum (40 mg/kg/day) on neural stem cells, cell proliferation, neuroblast differentiation, and mature neurons in the dentate gyrus of the hippocampus. These experiments were performed in both high-fat diet and low-fat diet-fed C57BL/6J mice via immunohistochemistry using the relevant marker for each cell type, including nestin, Ki67, doublecortin, and NeuN. Subchronic exposure to aluminum in both low-fat and high-fat diet-fed mice reduced neural stem cells, cell proliferation, and neuroblast differentiation without any changes in mature neurons. Furthermore, this reduction effect was exacerbated in high-fat diet-fed mice. These results suggest that aluminum accelerates the reduction of neural stem cells, cell proliferation, and neuroblast differentiation additively or synergistically in high-fat diet-fed mice without any harmful changes in mature neurons.
C1 [Nam, Sung Min; Kim, Jong Whi; Yoo, Dae Young; Kim, Woosuk; Jung, Hyo Young; Hwang, In Koo; Seong, Je Kyung; Yoon, Yeo Sung] Seoul Natl Univ, Coll Vet Med, Dept Anat & Cell Biol, Seoul 151742, South Korea.
   [Nam, Sung Min; Kim, Jong Whi; Yoo, Dae Young; Kim, Woosuk; Jung, Hyo Young; Hwang, In Koo; Seong, Je Kyung; Yoon, Yeo Sung] Seoul Natl Univ, Res Inst Vet Sci, Seoul 151742, South Korea.
C3 Seoul National University (SNU); Seoul National University (SNU)
RP Yoon, YS (corresponding author), Seoul Natl Univ, Coll Vet Med, Dept Anat & Cell Biol, Seoul 151742, South Korea.
EM ysyoon@snu.ac.kr
RI Yoo, Dae Young/HTR-7911-2023
OI Seong, Je Kyung/0000-0003-1177-6958; Hwang, In Koo/0000-0002-0533-4638
FU Basic Science Research Program of the National Research Foundation;
   Korean government (MEST) [NRF-2012R1A1B3001256]
FX This research was supported by the Basic Science Research Program of the
   National Research Foundation funded by the Korean government (MEST)
   (NRF-2012R1A1B3001256).
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NR 41
TC 9
Z9 12
U1 0
U2 7
PU HUMANA PRESS INC
PI TOTOWA
PA 999 RIVERVIEW DRIVE SUITE 208, TOTOWA, NJ 07512 USA
SN 0163-4984
EI 1559-0720
J9 BIOL TRACE ELEM RES
JI Biol. Trace Elem. Res.
PD JAN
PY 2014
VL 157
IS 1
BP 51
EP 59
DI 10.1007/s12011-013-9861-y
PG 9
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 298VZ
UT WOS:000330353900008
PM 24265032
DA 2025-06-11
ER

PT J
AU Sun, L
   Yu, Y
   Huang, T
   An, P
   Yu, DX
   Yu, ZJ
   Li, HX
   Sheng, HG
   Cai, L
   Xue, J
   Jing, M
   Li, YX
   Lin, X
   Wang, FD
AF Sun, Liang
   Yu, Yu
   Huang, Tao
   An, Peng
   Yu, Danxia
   Yu, Zhijie
   Li, Huaixing
   Sheng, Hongguang
   Cai, Lu
   Xue, Jun
   Jing, Miao
   Li, Yixue
   Lin, Xu
   Wang, Fudi
TI Associations between Ionomic Profile and Metabolic Abnormalities in
   Human Population
SO PLOS ONE
LA English
DT Article
ID OXIDATIVE STRESS; MUTUAL INFORMATION; INSULIN-RESISTANCE; BIOLOGICAL
   SAMPLES; DIABETES-MELLITUS; FEATURE-SELECTION; IRON STORES; VITAMIN-D;
   TYPE-2; SERUM
AB Background: Few studies assessed effects of individual and multiple ions simultaneously on metabolic outcomes, due to methodological limitation.
   Methodology/Principal Findings: By combining advanced ionomics and mutual information, a quantifying measurement for mutual dependence between two random variables, we investigated associations of ion modules/networks with overweight/obesity, metabolic syndrome (MetS) and type 2 diabetes (T2DM) in 976 middle-aged Chinese men and women. Fasting plasma ions were measured by inductively coupled plasma mass spectroscopy. Significant ion modules were selected by mutual information to construct disease related ion networks. Plasma copper and phosphorus always ranked the first two among three specific ion networks associated with overweight/obesity, MetS and T2DM. Comparing the ranking of ion individually and in networks, three patterns were observed (1) "Individual ion," such as potassium and chrome, which tends to work alone; (2) "Module ion," such as iron in T2DM, which tends to act in modules/network; and (3) "odule-individual ion," such as copper in overweight/obesity, which seems to work equivalently in either way.
   Conclusions: In conclusion, by using the novel approach of the ionomics strategy and the information theory, we observed potential associations of ions individually or as modules/networks with metabolic disorders. Certainly, these findings need to be confirmed in future biological studies.
C1 [Sun, Liang; Yu, Yu; An, Peng; Yu, Danxia; Yu, Zhijie; Li, Huaixing; Lin, Xu; Wang, Fudi] Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Key Lab Nutr & Metab, Shanghai, Peoples R China.
   [Sun, Liang; Yu, Yu; Huang, Tao; An, Peng; Yu, Danxia; Yu, Zhijie; Li, Huaixing; Li, Yixue; Lin, Xu; Wang, Fudi] Chinese Acad Sci, Grad Sch, Shanghai, Peoples R China.
   [Huang, Tao; Li, Yixue] Chinese Acad Sci, Shanghai Inst Biol Sci, Key Lab Syst Biol, Shanghai, Peoples R China.
   [Sheng, Hongguang] Shanghai Xuhui Dist Cent Hosp, Dept Endocrinol, Shanghai, Peoples R China.
   [Cai, Lu] Univ Louisville, Dept Pediat, Louisville, KY 40292 USA.
   [Xue, Jun] Nanjing Med Univ, Nanjing People Hosp 1, Dept Hematol, Nanjing, Jiangsu, Peoples R China.
   [Jing, Miao] Agilent Technol Co Ltd, Life Sci & Chem Anal Grp, Shanghai, Peoples R China.
   [Li, Yixue] Shanghai Ctr Bioinformat Technol, Shanghai, Peoples R China.
C3 Chinese Academy of Sciences; Chinese Academy of Sciences; Chinese
   Academy of Sciences; University of Louisville; Nanjing Medical
   University; Agilent Technologies; Chinese Academy of Sciences
RP Sun, L (corresponding author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Key Lab Nutr & Metab, Shanghai, Peoples R China.
EM yxli@sibs.ac.cn; xlin@sibs.ac.cn; wangfd@sibs.ac.cn
RI An, Peng/GWZ-9176-2022; Cai, Lu/AAG-9920-2019; Li,
   Xiaoying/GYA-2677-2022; lin, xu/KOC-3517-2024; Li, YiXue/JRW-6306-2023;
   Jing, Miao/AAP-6553-2021; Wang, Fudi/L-7888-2018
OI Wang, Fudi/0000-0001-8730-0003; Yu, Danxia/0000-0002-1710-9382; An,
   Peng/0000-0002-0421-0035; Yu, Yu/0000-0003-2291-0606
FU Ministry of Science and Technology of China (973 Program) [2009CB941400,
   2011CB966200, 2011CB504002, 2008DFA31960, 2011CB910200]; National High
   Technology Research and Development Program (863 Program)
   [2009AA022704]; National Natural Science Foundation of China [10979071,
   30970665, 31030039, 30930081, 81021002, 90913009, 30901193]; Knowledge
   Innovation Program Project of the Chinese Academy of Sciences
   [KSCX2-EW-R-10, KSCX2-EW-R-04]; Chinese Academy of Sciences Hundred
   Talents Program [KSCX2-YW-R-141]; Science & Technology Commission of
   Shanghai Municipality grant [10JC1416800]; Chief Scientist Program of
   Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences
   [SIBS2008006]; Clinical Center of Shanghai Xuhui District Central
   Hospital grant [CRC2010012]; CAS/SAFEA International Partnership Program
   for Creative Research Teams; China Postdoctoral Science Foundation
   [20110490751, 2012M510902]; SIBS-CAS Outstanding Youth fellowship
   [2010KIP309]
FX This work was supported by research grants from the Ministry of Science
   and Technology of China (973 Program) (2009CB941400, 2011CB966200 to F.
   W., 2011CB504002 and 2008DFA31960 to X. L., and 2011CB910200 to Y.L.);
   the National High Technology Research and Development Program (863
   Program) (2009AA022704 to X. L.); the National Natural Science
   Foundation of China (10979071, 30970665, 31030039 to F. W., 30930081,
   81021002 to X. L., 90913009 to Y.L.; 30901193 to Y.Y.); the Knowledge
   Innovation Program Project of the Chinese Academy of Sciences
   (KSCX2-EW-R-10 to X. L. and KSCX2-EW-R-04 to Y.L.); Chinese Academy of
   Sciences Hundred Talents Program (KSCX2-YW-R-141 to F. W.); Science &
   Technology Commission of Shanghai Municipality grant (10JC1416800 to F.
   W.); Chief Scientist Program of Shanghai Institutes for Biological
   Sciences, Chinese Academy of Sciences (SIBS2008006 to X. L.) and
   Clinical Center of Shanghai Xuhui District Central Hospital grant
   (CRC2010012 to F. W.), the CAS/SAFEA International Partnership Program
   for Creative Research Teams and the China Postdoctoral Science
   Foundation (20110490751 to L. S.; 2012M510902 to Y.Y.) and SIBS-CAS
   Outstanding Youth fellowship (2010KIP309 to Y.Y.). F. W. is a scholar of
   the Hundred Talents Program of the Chinese Academy of Sciences. The
   funders had no role in study design, data collection and analysis,
   decision to publish, or preparation of the manuscript.
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NR 61
TC 68
Z9 74
U1 1
U2 43
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JUN 13
PY 2012
VL 7
IS 6
AR e38845
DI 10.1371/journal.pone.0038845
PG 10
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 959UV
UT WOS:000305341900054
PM 22719963
OA gold, Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Kelishadi, R
   Poursafa, P
AF Kelishadi, Roya
   Poursafa, Parinaz
TI Obesity and Air Pollution: Global Risk Factors for Pediatric
   Non-alcoholic Fatty Liver Disease
SO HEPATITIS MONTHLY
LA English
DT Review
DE Fatty Liver; Child; Obesity; Environmental Exposure; Prevention and
   Control; Air Pollution
ID SERUM ALANINE AMINOTRANSFERASE; DIESEL EXHAUST PARTICLES; INTIMA-MEDIA
   THICKNESS; METABOLIC SYNDROME; INSULIN-RESISTANCE; CHILDHOOD OBESITY;
   REFERENCE INTERVALS; SCHOOL-CHILDREN; LIPID PROFILE; PREVALENCE
AB Non-alcoholic fatty liver disease (NAFLD) is becoming as an important health problem in the pediatric age group. In addition to the well-documented role of obesity on the fatty changes in liver, there is a growing body of evidence about the role of environmental factors, such as smoking and air pollution, in NAFLD. Given that excess-body fat and exposure to air pollutants is accompanied by systemic low-grade inflammation, oxidative stress, as well as alterations in insulin/insulin-like growth factor and insulin resistance, all of which are etiological factors related to NAFLD, an escalating trend in the incidence of pediatric NAFLD can be expected in the near future. This review focuses on the current knowledge regarding the epidemiology, diagnosis and pathogenesis of pediatric NAFLD. The review also highlights the importance of studying the underlying mechanisms of pediatric NAFLD and the need for broadening efforts in prevention and control of the main risk factors. The two main universal risk factors for NAFLD, obesity and air pollution, have broad adverse health effects, and reducing their prevalence will help abate the serious health problems associated with pediatric NAFLD. (C) 2011 Kowsar M.P.Co. All rights reserved.
C1 [Poursafa, Parinaz] Islamic Azad Univ, Environm & Energy Dept, Sci & Res Branch, Tehran, Iran.
   [Kelishadi, Roya] Isfahan Univ Med Sci, Child Hlth Promot Res Ctr, Dept Pediat, Esfahan, Iran.
   [Kelishadi, Roya] Isfahan Univ Med Sci, Fac Med, Dept Pediat, Esfahan, Iran.
   [Poursafa, Parinaz] Isfahan Univ Med Sci, Environm Res Ctr, Esfahan, Iran.
C3 Islamic Azad University; Isfahan University of Medical Sciences; Isfahan
   University of Medical Sciences; Isfahan University of Medical Sciences
RP Poursafa, P (corresponding author), Islamic Azad Univ, Environm & Energy Dept, Sci & Res Branch, Tehran, Iran.
EM parinaz.poursafa@gmail.com
RI Kelishadi, Roya/E-6154-2012; Poursafa, Parinaz/U-2924-2017
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NR 108
TC 32
Z9 34
U1 2
U2 23
PU KOWSAR PUBL
PI HOENSBROEK
PA PATERSWEG 22,, HOENSBROEK, LIMBURG 6431 GC, NETHERLANDS
SN 1735-143X
EI 1735-3408
J9 HEPAT MON
JI Hepat. Mon.
PD OCT
PY 2011
VL 11
IS 10
BP 794
EP 802
DI 10.5812/kowsar.1735143X.746
PG 9
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 850KI
UT WOS:000297193100004
PM 22224077
OA hybrid, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Lecarpentier, Y
   Claes, V
   Hébert, JL
AF Lecarpentier, Yves
   Claes, Victor
   Hebert, Jean-Louis
TI PPARs, Cardiovascular Metabolism, and Function: Near- or
   Far-from-Equilibrium Pathways
SO PPAR RESEARCH
LA English
DT Review
ID ACTIVATED-RECEPTOR-ALPHA; FATTY-ACID OXIDATION; RIGHT-VENTRICULAR
   DYSPLASIA; CIRCADIAN CLOCK; GENE-EXPRESSION; SEGMENTATION CLOCK;
   SKELETAL-MUSCLE; BLOOD-PRESSURE; MICE LACKING; GAMMA COACTIVATOR-1
AB Peroxisome proliferator-activated receptors (PPAR alpha, beta/delta and gamma) play a key role in metabolic regulatory processes and gene regulation of cellular metabolism, particularly in the cardiovascular system. Moreover, PPARs have various extra metabolic roles, in circadian rhythms, inflammation and oxidative stress. In this review, we focus mainly on the effects of PPARs on some thermodynamic processes, which can behave either near equilibrium, or far-from-equilibrium. New functions of PPARs are reported in the arrhythmogenic right ventricular cardiomyopathy, a human genetic heart disease. It is now possible to link the genetic desmosomal abnormalitiy to the presence of fat in the right ventricle, partly due to an overexpression of PPAR.. Moreover, PPARs are directly or indirectly involved in cellular oscillatory processes such as the Wnt-b-catenin pathway, circadian rhythms of arterial blood pressure and cardiac frequency and glycolysis metabolic pathway. Dysfunction of clock genes and PPAR gamma may lead to hyperphagia, obesity, metabolic syndrome, myocardial infarction and sudden cardiac death, In pathological conditions, regulatory processes of the cardiovascular system may bifurcate towards new states, such as those encountered in hypertension, type 2 diabetes, and heart failure. Numerous of these oscillatorymechanisms, organized in time and space, behave far from equilibrium and are "dissipative structures".
C1 [Lecarpentier, Yves; Hebert, Jean-Louis] Hop Bicetre, Assistance Publ Hop Paris, Serv Physiol, F-94275 Le Kremlin Bicetre, France.
   [Lecarpentier, Yves; Hebert, Jean-Louis] Univ Paris 11, Dept Physiol Humaine, F-94275 Le Kremlin Bicetre, France.
   [Lecarpentier, Yves] Ctr Hosp Reg Meaux, Ctr Rech Clin, F-77100 Meaux, France.
   [Claes, Victor] Univ Antwerp, Dept Pharmaceut Sci, B-2670 Antwerp, Belgium.
C3 Assistance Publique Hopitaux Paris (APHP); Hopital Universitaire
   Antoine-Beclere - APHP; Hopital Universitaire Bicetre - APHP; Universite
   Paris Saclay; Universite Paris Cite; Hopital Universitaire Saint-Louis -
   APHP; Universite Paris Saclay; University of Antwerp
RP Lecarpentier, Y (corresponding author), Hop Bicetre, Assistance Publ Hop Paris, Serv Physiol, F-94275 Le Kremlin Bicetre, France.
EM lecarpentier.y@wanadoo.fr
OI HEBERT, Jean-Louis/0000-0001-6049-0601; Claes,
   Victor/0000-0002-1914-0228
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NR 120
TC 21
Z9 22
U1 0
U2 7
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1687-4757
EI 1687-4765
J9 PPAR RES
JI PPAR Res.
PY 2010
VL 2010
AR 783273
DI 10.1155/2010/783273
PG 10
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 670MQ
UT WOS:000283427700001
PM 20706650
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Fujita, K
   Maeda, N
   Sonoda, M
   Ohashi, K
   Hibuse, T
   Nishizawa, H
   Nishida, M
   Hiuge, A
   Kurata, A
   Kihara, S
   Shimomura, I
   Funahashi, T
AF Fujita, Koichi
   Maeda, Norikazu
   Sonoda, Mina
   Ohashi, Koji
   Hibuse, Toshiyuki
   Nishizawa, Hitoshi
   Nishida, Makoto
   Hiuge, Aki
   Kurata, Akifumi
   Kihara, Shinji
   Shimomura, Iichiro
   Funahashi, Tohru
TI Adiponectin protects against angiotensin II-induced cardiac fibrosis
   through activation of PPAR-α
SO ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
LA English
DT Article
DE adiponectin; angiotensin II; PPAR-alpha; fibrosis; AMPK
ID METABOLIC SYNDROME; GENE-EXPRESSION; HEART-FAILURE; DEFICIENT MICE;
   HYPERTROPHY; KINASE; ATHEROSCLEROSIS; INFLAMMATION; OBESITY; STRESS
AB Objectives-Adiponectin is recognized as an antidiabetic, antiatherosclerotic, and anti-inflammatory protein derived from adipocytes. However, the role of adiponectin in cardiac fibrosis remains uncertain. We herein explore the effects of adiponectin on cardiac fibrosis induced by angiotensin II (Ang II).
   Methods and Results-Wild-type (WT), adiponectin knockout (Adipo-KO), and PPAR-alpha knockout (PPAR-alpha-KO) mice were infused with Ang II at 1.2 mg/kg/d. Severe cardiac fibrosis and left ventricular dysfunction were observed in Ang II-infused Adipo-KO mice compared to WT mice. Adenovirus-mediated adiponectin treatment improved the above phenotypes and the dysregulation of reactive oxygen species (ROS)-related mRNAs in Adipo-KO mice, whereas such amelioration was not observed in PPAR-alpha-KO mice despite adiponectin accumulation in heart tissue. In cultured cardiac fibroblasts, adiponectin improved the reduction of AMP-activated protein kinase (AMPK) activity and elevation of extracellular signal-regulated kinase 1/2 (ERK1/2) activity induced by Ang II. Adiponectin significantly enhanced PPAR-alpha activity, whereas the adiponectin-dependent PPAR-alpha activation was diminished by Compound C, an inhibitor of AMPK.
   Conclusion-The present study suggests that adiponectin protects against Ang II-induced cardiac fibrosis possibly through AMPK-dependent PPAR-alpha activation.
C1 [Fujita, Koichi; Maeda, Norikazu; Sonoda, Mina; Ohashi, Koji; Hibuse, Toshiyuki; Nishizawa, Hitoshi; Nishida, Makoto; Hiuge, Aki; Kurata, Akifumi; Kihara, Shinji; Shimomura, Iichiro; Funahashi, Tohru] Osaka Univ, Grad Sch Med, Dept Metab Med, Suita, Osaka 5650871, Japan.
C3 The University of Osaka
RP Maeda, N (corresponding author), Osaka Univ, Grad Sch Med, Dept Metab Med, 2-2-B5 Yamadaoka, Suita, Osaka 5650871, Japan.
EM nmaeda@imed2.med.osaka-u.ac.jp
RI OHASHI, Koji/I-7307-2014; Maeda, Norikazu/LZI-4561-2025; Kihara,
   Shinji/AAW-2015-2021
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NR 33
TC 168
Z9 183
U1 0
U2 12
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1079-5642
J9 ARTERIOSCL THROM VAS
JI Arterioscler. Thromb. Vasc. Biol.
PD MAY
PY 2008
VL 28
IS 5
BP 863
EP 870
DI 10.1161/ATVBAHA.107.156687
PG 8
WC Hematology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Hematology; Cardiovascular System & Cardiology
GA 289LT
UT WOS:000255056700015
PM 18309113
OA Green Submitted, Bronze
DA 2025-06-11
ER

PT J
AU Houstis, N
   Rosen, ED
   Lander, ES
AF Houstis, N
   Rosen, ED
   Lander, ES
TI Reactive oxygen species have a causal role in multiple forms of insulin
   resistance
SO NATURE
LA English
DT Article
ID NECROSIS-FACTOR-ALPHA; OXIDATIVE STRESS; TNF-ALPHA; GLUT4 TRANSLOCATION;
   METABOLIC SYNDROME; 3T3-L1 ADIPOCYTES; OBESITY; JNK; EXPRESSION;
   PREGNANCY
AB Insulin resistance is a cardinal feature of type 2 diabetes and is characteristic of a wide range of other clinical and experimental settings. Little is known about why insulin resistance occurs in so many contexts. Do the various insults that trigger insulin resistance act through a common mechanism? Or, as has been suggested(1), do they use distinct cellular pathways? Here we report a genomic analysis of two cellular models of insulin resistance, one induced by treatment with the cytokine tumour-necrosis factor-alpha and the other with the glucocorticoid dexamethasone. Gene expression analysis suggests that reactive oxygen species (ROS) levels are increased in both models, and we confirmed this through measures of cellular redox state. ROS have previously been proposed to be involved in insulin resistance, although evidence for a causal role has been scant. We tested this hypothesis in cell culture using six treatments designed to alter ROS levels, including two small molecules and four transgenes; all ameliorated insulin resistance to varying degrees. One of these treatments was tested in obese, insulin-resistant mice and was shown to improve insulin sensitivity and glucose homeostasis. Together, our findings suggest that increased ROS levels are an important trigger for insulin resistance in numerous settings.
C1 MIT, Broad Inst, Cambridge, MA 02141 USA.
   Harvard Univ, Broad Inst, Cambridge, MA 02141 USA.
   MIT, Dept Biol, Cambridge, MA 02139 USA.
   Whitehead Inst Biomed Res, Cambridge, MA 02142 USA.
   Beth Israel Deaconess Med Ctr, Div Endocrinol, Dept Med, Boston, MA 02214 USA.
   Harvard Univ, Sch Med, Dept Syst Biol, Boston, MA 02115 USA.
C3 Harvard University; Massachusetts Institute of Technology (MIT); Broad
   Institute; Harvard University; Massachusetts Institute of Technology
   (MIT); Broad Institute; Massachusetts Institute of Technology (MIT);
   Massachusetts Institute of Technology (MIT); Whitehead Institute;
   Harvard University; Harvard University Medical Affiliates; Beth Israel
   Deaconess Medical Center; Harvard University; Harvard Medical School
RP MIT, Broad Inst, Cambridge, MA 02141 USA.
EM erosen@bidmc.harvard.edu; lander@broad.mit.edu
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NR 30
TC 2029
Z9 2280
U1 8
U2 364
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0028-0836
EI 1476-4687
J9 NATURE
JI Nature
PD APR 13
PY 2006
VL 440
IS 7086
BP 944
EP 948
DI 10.1038/nature04634
PG 5
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 031WU
UT WOS:000236736700043
PM 16612386
DA 2025-06-11
ER

PT J
AU Kossiva, L
   Kakleas, K
   Christodouli, F
   Soldatou, A
   Karanasios, S
   Karavanaki, K
AF Kossiva, Lydia
   Kakleas, Kostas
   Christodouli, Foteini
   Soldatou, Alexandra
   Karanasios, Spyridon
   Karavanaki, Kyriaki
TI Chronic Use of Artificial Sweeteners: Pros and Cons
SO NUTRIENTS
LA English
DT Review
DE non-nutritional sweeteners; artificial sweeteners; side effects;
   glycemic control; diabetes; obesity; nonalcoholic fatty liver disease;
   cancer; gut microbiota; favorable effects
ID ENDOPLASMIC-RETICULUM STRESS; FATTY LIVER-DISEASE; NONNUTRITIVE
   SWEETENERS; INSULIN-RESISTANCE; METABOLIC SYNDROME; SUGAR; CONSUMPTION;
   BEVERAGES; CANCER; RISK
AB Over the past few decades, the scientific community has been highly concerned about the obesity epidemic. Artificial sweeteners are compounds that mimic the sweet taste of sugar but have no calories or carbohydrates; hence, they are very popular among patients suffering from diabetes or obesity, aiming to achieve glycemic and/or weight control. There are four different types of sweeteners: artificial, natural, rare sugars, and polyols. Artificial and natural sweeteners are characterized as non-nutritional sweeteners (NNSs) since they do not contain calories. The extended use of sweeteners has been reported to have a favorable impact on body weight and glycemic control in patients with type 2 diabetes (T2DM) and on tooth decay prevention. However, there is concern regarding their side effects. Several studies have associated artificial sweeteners' consumption with the development of insulin resistance, nonalcoholic fatty liver disease (NAFLD), gastrointestinal symptoms, and certain types of cancer. The present review focuses on the description of different types of sweeteners and the benefits and possible deleterious effects of the chronic consumption of NNSs on children's health. Additionally, possible underlying mechanisms of the unfavorable effects of NNSs on human health are described.
C1 [Kossiva, Lydia; Christodouli, Foteini; Soldatou, Alexandra; Karanasios, Spyridon; Karavanaki, Kyriaki] Natl & Kapodistrian Univ Athens, P&A Kyriakou Childrens Hosp, Dept Pediat 2, Diabet & Metab Clin, Athens 11527, Greece.
   [Kakleas, Kostas] Natl & Kapodistrian Univ Athens, Agia Sophia Childrens Hosp, 1st Dept Pediat, Athens 11527, Greece.
C3 National & Kapodistrian University of Athens; The Aghia Sophia
   Children's Hospital; National & Kapodistrian University of Athens
RP Karavanaki, K (corresponding author), Natl & Kapodistrian Univ Athens, P&A Kyriakou Childrens Hosp, Dept Pediat 2, Diabet & Metab Clin, Athens 11527, Greece.
EM lydiakossiva@hotmail.com; koskakl2@yahoo.gr;
   foteini.christodouli@nhs.net; asoldat@med.uoa.gr; spyroskara97@yahoo.gr;
   kkarav@yahoo.gr
RI Kossiva, Lydia/ABN-0636-2022; Kakleas, Konstantinos/F-4988-2010
OI Kossiva, Lydia/0000-0002-0476-6586; Kakleas,
   Konstantinos/0000-0002-7993-8418; KARAVANAKI,
   KYRIAKI/0000-0001-5323-2786
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NR 140
TC 4
Z9 4
U1 19
U2 35
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD SEP
PY 2024
VL 16
IS 18
AR 3162
DI 10.3390/nu16183162
PG 16
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA H5S6G
UT WOS:001324041000001
PM 39339762
OA gold
DA 2025-06-11
ER

PT J
AU Patel, RN
   Sharma, A
   Prasad, A
   Bansal, S
AF Patel, Rahul N.
   Sharma, Akash
   Prasad, Anand
   Bansal, Shweta
TI Heart Failure With Preserved Ejection Fraction With CKD: A Narrative
   Review of a Multispecialty Disorder
SO KIDNEY MEDICINE
LA English
DT Review
ID CHRONIC KIDNEY-DISEASE; MINERALOCORTICOID RECEPTOR ACTIVATION; EXERCISE
   CAPACITY; RENAL-FUNCTION; CARDIAC-FUNCTION; OUTCOMES; SPIRONOLACTONE;
   DYSFUNCTION; HYPERTENSION; ASSOCIATION
AB Heart failure with preserved ejection fraction (HFpEF) is a heterogenous syndrome with varying phenotypic expression. The phenotype chronic kidney disease (CKD) associated HFpEF is increasing in prevalence globally and is associated with increased morbidity and mortality compared to other HFpEF variants. These 2 conditions share common risk factors, including obesity, diabetes, and metabolic syn-drome, as well as similar pathophysiology, including systemic inflammation, oxidative stress, elevated neurohormones, mineralocorticoid-receptor activation, and venous congestion. Given the coexistence of CKD and HFpEF, the diagnosis of HFpEF can be difficult. Moreover, treatment options for HFpEF have remained limited despite the success seen in its counterpart, heart failure with reduced ejection fraction. HFpEF encompasses complex multisystem pathophysiological perturbations beyond neurohormones, it is unlikely that a single agent can have significant benefit in this population. Recent data on sodium-glucose cotransporter 2 (SGLT2) inhibitors in HFpEF and CKD, and on glucagon-like peptide-1 (GLP-1) agonists and mineralocorticoid-receptor antagonists in metabolic syndrome, which target multiple pathways simultaneously, have led to promising therapeutics for HFpEF and CKD. In this perspective, our goal is to increase awareness of HFpEF as a multisystem disorder that shares the same disease processes seen in CKD and to emphasize that its management in individuals with CKD warrants a collective and multidisciplinary approach.
C1 [Patel, Rahul N.] Emory Univ, Sch Med, Transplant Renal Med, Atlanta, GA USA.
   [Sharma, Akash] Univ Texas Hlth Sci Ctr, San Antonio Joe R Teresa Lozano Long Sch Med, San Antonio, TX USA.
   [Prasad, Anand] Univ Texas Hlth San Antonio, Div Cardiol, San Antonio, TX USA.
   [Bansal, Shweta] Univ Texas Hlth San Antonio, Div Nephrol, San Antonio, TX USA.
   [Bansal, Shweta] Univ Texas Hlth San Antonio, Dept Med, Div Nephrol, 7703 Floyd Curl Dr, MSC 7882, San Antonio, TX 78229 USA.
C3 Emory University; University of Texas System; University of Texas Health
   Science Center at San Antonio; University of Texas System; University of
   Texas Health Science Center at San Antonio; University of Texas System;
   University of Texas Health Science Center at San Antonio; University of
   Texas System; University of Texas Health Science Center at San Antonio
RP Bansal, S (corresponding author), Univ Texas Hlth San Antonio, Dept Med, Div Nephrol, 7703 Floyd Curl Dr, MSC 7882, San Antonio, TX 78229 USA.
EM bansals3@uthscsa.edu
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NR 81
TC 9
Z9 10
U1 0
U2 0
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2590-0595
J9 KIDNEY MED
JI Kidney Med.
PD DEC
PY 2023
VL 5
IS 12
AR 100705
DI 10.1016/j.xkme.2023.100705
EA NOV 2023
PG 10
WC Urology & Nephrology
WE Emerging Sources Citation Index (ESCI)
SC Urology & Nephrology
GA FP1P1
UT WOS:001146955900001
PM 38046909
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Chen, YL
   Jiang, HG
   Zhan, ZK
   Lu, JD
   Gu, TW
   Yu, P
   Liang, WM
   Zhang, X
   Liu, SW
   Bi, HC
   Zhong, SL
   Tang, L
AF Chen, Yulian
   Jiang, Huanguo
   Zhan, Zhikun
   Lu, Jindi
   Gu, Tanwei
   Yu, Ping
   Liang, Weimin
   Zhang, Xi
   Liu, Shuwen
   Bi, Huichang
   Zhong, Shilong
   Tang, Lan
TI Restoration of lipid homeostasis between TG and PE by the LXRα-ATGL/EPT1
   axis ameliorates hepatosteatosis
SO CELL DEATH & DISEASE
LA English
DT Article
ID LIVER-X-RECEPTOR; PPAR-ALPHA; ER STRESS; METABOLISM; LXR;
   PHOSPHATIDYLCHOLINE; ACCUMULATION; ACTIVATION; DROPLETS; HEALTH
AB Converting lipid disturbances in response to energy oversupply into healthy lipid homeostasis is a promising therapy to alleviate hepatosteatosis. Our clinical studies found that a further elevation of triglyceride (TG) in obese patients with the body mass index (BMI) greater than 28 was accompanied by a further reduction of phosphatidylethanolamine (PE). Shorter survival and poor prognosis were shown for the patients with high TG and low PE levels. Liver X receptor alpha (LXR alpha) knockout mice aggravated high-fat diet (HFD)-induced obesity and lipid disorders, making the TG enrichment and the PE decrease more pronounced according to the liver lipidomics analysis. The RNA-seq from mice liver exhibited that these metabolism disorders were attributed to the decline of Atgl (encoding the TG metabolism enzyme ATGL) and Ept1 (encoding the PE synthesis enzyme EPT1) expression. Mechanistic studies uncovered that LXR alpha activated the ATGL and EPT1 gene via direct binding to a LXR response element (LXRE) in the promoter. Moreover, both the supplement of PE in statin or fibrate therapy, and the LXR alpha inducer (oridonin) ameliorated cellular lipid deposition and lipotoxicity. Altogether, restoration of lipid homeostasis of TG and PE via the LXR alpha-ATGL/EPT1 axis may be a potential approach for the management of hepatosteatosis and metabolic syndrome.
C1 [Chen, Yulian; Jiang, Huanguo; Zhan, Zhikun; Lu, Jindi; Gu, Tanwei; Yu, Ping; Liang, Weimin; Zhang, Xi; Liu, Shuwen; Bi, Huichang; Zhong, Shilong; Tang, Lan] Southern Med Univ, Sch Pharmaceut Sci, NMPA Key Lab Res & Evaluat Drug Metab, Guangdong Prov Key Lab New Drug Screening, Guangzhou 510515, Peoples R China.
   [Zhong, Shilong] Southern Med Univ, Guangdong Prov Peoples Hosp, Guangdong Acad Med Sci, Dept Pharm, Guangzhou, Peoples R China.
C3 Southern Medical University - China; Guangdong Academy of Medical
   Sciences & Guangdong General Hospital; Southern Medical University -
   China
RP Zhong, SL; Tang, L (corresponding author), Southern Med Univ, Sch Pharmaceut Sci, NMPA Key Lab Res & Evaluat Drug Metab, Guangdong Prov Key Lab New Drug Screening, Guangzhou 510515, Peoples R China.; Zhong, SL (corresponding author), Southern Med Univ, Guangdong Prov Peoples Hosp, Guangdong Acad Med Sci, Dept Pharm, Guangzhou, Peoples R China.
EM zhongsl@hotmail.com; tl405@smu.edu.cn
RI Liu, Shuwen/D-1514-2012; tang, lan/O-8768-2017; Li, Xuming/JLM-6754-2023
OI Chen, Yulian/0000-0002-8860-1876
FU National Natural Science Foundation of China [82274002, 81973388];
   Marine Economy Development Project of Guangdong Province; Key Research
   and Development Program of Guangdong Province [2020B1111030005,
   S2021ZDZ042]; Science and Technology Innovation Project of Guangdong
   Medical Products Administration [GDNRC[2021]52];  [2019B020202002]
FX This work was supported by the National Natural Science Foundation of
   China (Nos. 82274002 and 81973388), Marine Economy Development Project
   of Guangdong Province (GDNRC[2021]52), the Key Research and Development
   Program of Guangdong Province (2019B020202002, 2020B1111030005), and the
   Science and Technology Innovation Project of Guangdong Medical Products
   Administration (S2021ZDZ042).
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NR 49
TC 14
Z9 15
U1 2
U2 28
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 2041-4889
J9 CELL DEATH DIS
JI Cell Death Dis.
PD FEB 6
PY 2023
VL 14
IS 2
AR 85
DI 10.1038/s41419-023-05613-6
PG 17
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA 8P2ZT
UT WOS:000926395900002
PM 36746922
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Pal, SC
   Eslam, M
   Mendez-Sanchez, N
AF Pal, Shreya C.
   Eslam, Mohammed
   Mendez-Sanchez, Nahum
TI Detangling the interrelations between MAFLD, insulin resistance, and key
   hormones
SO HORMONES-INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM
LA English
DT Review
DE MAFLD; Insulin resistance; Adipokines; Estrogen
ID FATTY LIVER-DISEASE; SERUM URIC-ACID; NONALCOHOLIC STEATOHEPATITIS;
   METABOLIC SYNDROME; OXIDATIVE STRESS; LEPTIN; EPIGENETICS; ASSOCIATION;
   STEATOSIS; OBESITY
AB Metabolic dysfunction-associated fatty liver disease (MAFLD) has increasingly become a significant and highly prevalent cause of chronic liver disease, displaying a wide array of risk factors and pathophysiologic mechanisms of which only a few have so far been clearly elucidated. A bidirectional interaction between hormonal discrepancies and metabolic-related disorders, including obesity, type 2 diabetes mellitus (T2DM), and polycystic ovarian syndrome (PCOS) has been described. Since the change in nomenclature from non-alcoholic fatty liver disease (NAFLD) to MAFLD is based on the clear impact of metabolic elements on the disease, the reciprocal interactions of hormones such as insulin, adipokines (leptin and adiponectin), and estrogens have strongly pointed to the intrinsic links that lead to the heterogeneous epidemiology, clinical presentations, and risk factors involved in MAFLD in different populations. The objective of this work is twofold. Firstly, there is a brief discussion regarding the change in nomenclature as well as epidemiology, risk factors, and pathophysiologic mechanisms other than hormonal effects, which include nutrition and the gut microbiome, as well as genetic and epigenetic influences. Secondly, we review the basis of the most important hormonal factors involved in the development and progression of MAFLD that act both independently and in an interrelated manner.
C1 [Pal, Shreya C.; Mendez-Sanchez, Nahum] Univ Nacl Autonoma Mexico, Fac Med, Ave Univ 3000, Mexico City 4510, DF, Mexico.
   [Pal, Shreya C.; Mendez-Sanchez, Nahum] Medica Sur Clin & Fdn, Liver Res Unit, Puente Piedra 150, Mexico City 14050, DF, Mexico.
   [Eslam, Mohammed] Univ Sydney, Storr Liver Ctr, Westmead Inst Med Res, Westmead Hosp, Sydney, NSW, Australia.
C3 Universidad Nacional Autonoma de Mexico; NSW Health; Westmead Hospital;
   University of Sydney; Westmead Institute for Medical Research
RP Mendez-Sanchez, N (corresponding author), Univ Nacl Autonoma Mexico, Fac Med, Ave Univ 3000, Mexico City 4510, DF, Mexico.; Mendez-Sanchez, N (corresponding author), Medica Sur Clin & Fdn, Liver Res Unit, Puente Piedra 150, Mexico City 14050, DF, Mexico.
EM nmendez@medicasur.org.mx
RI Eslam, Mohammed/JAD-0534-2023
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NR 157
TC 27
Z9 27
U1 2
U2 16
PU SPRINGER INT PUBL AG
PI CHAM
PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND
SN 1109-3099
EI 2520-8721
J9 HORM-INT J ENDOCRINO
JI Horm.-Int. J. Endocrinol. Metab.
PD DEC
PY 2022
VL 21
IS 4
BP 573
EP 589
DI 10.1007/s42000-022-00391-w
EA AUG 2022
PG 17
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 6S5HN
UT WOS:000835599300001
PM 35921046
DA 2025-06-11
ER

PT J
AU Flores-León, M
   Pérez-Domínguez, M
   González-Barrios, R
   Arias, C
AF Flores-Leon, Manuel
   Perez-Dominguez, Martha
   Gonzalez-Barrios, Rodrigo
   Arias, Clorinda
TI Palmitic Acid-Induced NAD<SUP>+</SUP> Depletion is Associated with the
   Reduced Function of SIRT1 and Increased Expression of BACE1 in
   Hippocampal Neurons
SO NEUROCHEMICAL RESEARCH
LA English
DT Article
DE Palmitic acid; SIRT1; BACE1 expression; Neuronal NAD(+); Hippocampal
   neurons
ID NF-KAPPA-B; AMYLOID PRECURSOR PROTEIN; FREE FATTY-ACIDS;
   INSULIN-RESISTANCE; ALZHEIMER-DISEASE; BETA; MITOCHONDRIAL; ACTIVATION;
   STRESS; DYSFUNCTION
AB Increased levels of circulating fatty acids, such as palmitic acid (PA), are associated with the development of obesity, insulin resistance, type-2 diabetes and metabolic syndrome. Furthermore, these diseases are linked to an increased risk of cancer, cardiovascular diseases, mild cognitive impairment and even Alzheimer's disease (AD). However, the precise actions of elevated PA levels on neurons and their association with neuronal metabolic disruption that leads to the expression of pathological markers of AD, such as the overproduction and accumulation of the amyloid- peptide, represent an area of intense investigation. A possible molecular mechanism involved in the effects of PA may be through dysfunction of the NAD(+) sensor enzyme, SIRT1. Therefore, the aim of the present study was to analyze the relationship between the effects of PA metabolism on the function of SIRT1 and the upregulation of BACE1 in cultured hippocampal neurons. PA reduced the total amount of NAD(+) in neurons that caused an increase in p65 K310 acetylation due to inhibition of SIRT1 activity and low protein content. Furthermore, BACE1 protein and its activity were increased, and BACE1 was relocated in neurites after PA exposure.
C1 [Flores-Leon, Manuel; Perez-Dominguez, Martha; Arias, Clorinda] Univ Nacl Autonoma Mexico, Inst Invest Biomed, Dept Med Genom & Toxicol Ambiental, AP 70-228, Mexico City 04510, DF, Mexico.
   [Gonzalez-Barrios, Rodrigo] Univ Nacl Autonoma Mexico, IIB, INCan, Unidad Invest Biomed Canc, Mexico City 14080, DF, Mexico.
C3 Universidad Nacional Autonoma de Mexico; Universidad Nacional Autonoma
   de Mexico; Instituto Nacional de Cancerologia (INCAN)
RP Arias, C (corresponding author), Univ Nacl Autonoma Mexico, Inst Invest Biomed, Dept Med Genom & Toxicol Ambiental, AP 70-228, Mexico City 04510, DF, Mexico.
EM carias@unam.mx
RI Gonzalez, Rodrigo/MBH-6980-2025
OI Arias, Clorinda/0000-0002-5873-2904; Gonzalez Barrios,
   Rodrigo/0000-0001-8982-6586; Perez Dominguez,
   Martha/0000-0003-2235-3328; Flores Leon, Manuel/0000-0002-1094-8773
FU Universidad Nacional Autonoma de Mexico (UNAM) [PAPIIT IN202615];
   CONACYT [449712]
FX This work was supported by Universidad Nacional Autonoma de Mexico
   (UNAM) (PAPIIT IN202615). The authors thank Patricia Ferrera for
   technical assistance and Miguel Tapia-Rodriguez for confocal microscopy
   assistance. M Flores-Leon is a doctoral student from Programa de
   Doctorado en Ciencias Bioquimicas, Universidad Nacional Autonoma de
   Mexico (UNAM) and received a fellowship from CONACYT (449712).
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NR 62
TC 18
Z9 20
U1 0
U2 12
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0364-3190
EI 1573-6903
J9 NEUROCHEM RES
JI Neurochem. Res.
PD JUL
PY 2019
VL 44
IS 7
BP 1745
EP 1754
DI 10.1007/s11064-019-02810-8
PG 10
WC Biochemistry & Molecular Biology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Neurosciences & Neurology
GA IC1VR
UT WOS:000470748000019
PM 31073968
DA 2025-06-11
ER

PT J
AU Cavarzere, P
   Mauro, M
   Vincenzi, M
   Lauriola, S
   Teofoli, F
   Gaudino, R
   Ramaroli, DA
   Micciolo, R
   Camilot, M
   Antoniazzi, F
AF Cavarzere, Paolo
   Mauro, Margherita
   Vincenzi, Monica
   Lauriola, Silvana
   Teofoli, Francesca
   Gaudino, Rossella
   Ramaroli, Diego Alberto
   Micciolo, Rocco
   Camilot, Marta
   Antoniazzi, Franco
TI Children with premature pubarche: is an alterated neonatal 17-Ohp
   screening test a predictive factor?
SO ITALIAN JOURNAL OF PEDIATRICS
LA English
DT Article
DE Premature pubarche; 17-Ohp; Newborn screening; Congenital adrenal
   hyperplasia
ID CONGENITAL ADRENAL-HYPERPLASIA; STEROID 21-HYDROXYLASE DEFICIENCY;
   BIRTH-WEIGHT; 17-HYDROXYPROGESTERONE LEVELS; PRECOCIOUS PUBARCHE;
   METABOLIC SYNDROME; GESTATIONAL-AGE; PRETERM INFANTS;
   17-ALPHA-HYDROXYPROGESTERONE; HYPERANDROGENISM
AB Background: Neonatal screening for 21 hydroxylase deficiency is designed to detect classical form of congenital adrenal hyperplasia (CAH). It is still unclear whether newborns who result false positives at neonatal screening might later develop signs of androgen excess. The aim of this study is to verify whether a slightly elevated 17-OHP at newborn screening is a predictive factor for premature pubarche.
   Methods: We evaluated all infants born between 2001 and 2014 with premature pubarche. In case of increased bone age, they were submitted to functional tests to find out the cause of their symptoms. Their 17-OHP values at newborn screening for CAH were reconsidered.
   Results: We identified 330 patients (269 females, 61 males) with premature pubarche. All these children had a normal 17-OHP at newborn screening with the exception of a child, born preterm and not affected by CAH.
   Conclusions: An elevated 17-OHP at newborn screening is not a predictive factor for premature pubarche. A likely cause of increased 17-OHP level at screening is an immaturity of adrenal gland or a neonatal stress. Therefore a strict follow up of these neonates during childhood is not necessary.
C1 [Cavarzere, Paolo; Mauro, Margherita; Vincenzi, Monica; Teofoli, Francesca; Gaudino, Rossella; Ramaroli, Diego Alberto; Camilot, Marta; Antoniazzi, Franco] Univ Hosp Verona, Pediat Div, Dept Pediat, Verona, Italy.
   [Lauriola, Silvana] Univ Hosp Verona, Dept Pediat, Neonatal Intens Care Unit, Verona, Italy.
   [Micciolo, Rocco] Univ Trento, Dept Psychol & Cognit Sci, Trento, Italy.
   [Antoniazzi, Franco] Univ Verona, Dept Surg Sci Dent Gynecol & Pediat, Pediat Clin, Reg Ctr Diag & Treatment Children & Adolescents R, Verona, Italy.
C3 University of Verona; Azienda Ospedaliera Universitaria Integrata
   Verona; University of Verona; Azienda Ospedaliera Universitaria
   Integrata Verona; University of Trento; University of Verona
RP Cavarzere, P (corresponding author), Univ Hosp Verona, Pediat Div, Dept Pediat, Verona, Italy.
EM paolocavarzere@yahoo.it
RI Antoniazzi, Franco/IAP-9887-2023; Gaudino, Rossella/HKN-4423-2023
OI Micciolo, Rocco/0000-0002-8299-9879; Antoniazzi,
   Franco/0000-0003-1405-1792; Gaudino, Rossella/0000-0002-6292-0246
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NR 49
TC 5
Z9 6
U1 0
U2 0
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1720-8424
EI 1824-7288
J9 ITAL J PEDIATR
JI Ital. J. Pediatr.
PD JAN 16
PY 2018
VL 44
AR 10
DI 10.1186/s13052-018-0444-6
PG 6
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA FT0WK
UT WOS:000422849200001
PM 29338783
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Li, BS
   Guo, JJ
   Xi, ZH
   Xu, J
   Zuo, ZH
   Wang, CG
AF Li, Bingshui
   Guo, Jiaojiao
   Xi, Zhihui
   Xu, Jing
   Zuo, Zhenghong
   Wang, Chonggang
TI Tributyltin in male mice disrupts glucose homeostasis as well as
   recovery after exposure: mechanism analysis
SO ARCHIVES OF TOXICOLOGY
LA English
DT Article
DE Organotins; Diabetes; Insulin receptor pathway; Mechanism; Glucagon
ID PERSISTENT ORGANIC POLLUTANTS; INSULIN-RESISTANCE; SERUM CONCENTRATIONS;
   ORGANOTIN COMPOUNDS; GLUCAGON-SECRETION; BUTYLTIN COMPOUNDS; METABOLIC
   SYNDROME; ADIPOSE-TISSUE; ADIPONECTIN; RECEPTOR
AB Organotin compounds such as tributyltin (TBT) and triphenyltin can induce diabetes and insulin resistance. However, the development of diabetes caused by organotins and its underlying mechanisms remain unclear. In the present study, male KM mice were orally administered with TBT (0.5, 5, and 50 mu g/kg) once every 3 days for 45 days. Their body weights increased and reached a significant difference compared to the control, and the fasting blood glucose levels were significantly elevated. The fasting levels of serum insulin and adiponectin increased, while glucagon levels decreased in the animals treated with TBT. The expression of the insulin receptor (IR) signaling cascade, including IR, IR substrate, phosphatidylinositol 3-kinase, Akt, and glucose transporter 4, was inhibited both in the skeletal muscle and the liver, which might be a main reason for the hyperglycemia and hyperinsulinemia. After removing the TBT stress for 60 days, the animals which had received exposure to TBT could recover normoglycemia, accompanied with a recovery of the suppressed IR signal pathway and fasting insulin levels. However, the fasting levels of serum adiponectin and glucagon were lower than that of the control mice, which would remain a potential risk inducing the disruption of glucose homeostasis.
C1 [Li, Bingshui; Guo, Jiaojiao; Xi, Zhihui; Xu, Jing; Zuo, Zhenghong; Wang, Chonggang] Xiamen Univ, Sch Life Sci, State Key Lab Cellular Stress Biol, Xiamen, Peoples R China.
   [Wang, Chonggang] Xiamen Univ, State Key Lab Marine Environm Sci, Xiamen, Peoples R China.
C3 Xiamen University; Xiamen University
RP Wang, CG (corresponding author), Xiamen Univ, Sch Life Sci, State Key Lab Cellular Stress Biol, Xiamen, Peoples R China.; Wang, CG (corresponding author), Xiamen Univ, State Key Lab Marine Environm Sci, Xiamen, Peoples R China.
EM cgwang@xmu.edu.cn
RI Wang, CG/G-4583-2010; Zuo, Zhenghong/G-4615-2010; Xi,
   Zhihui/JSL-3375-2023
FU National Natural Science Foundation of China [21577113]
FX This work was supported by the National Natural Science Foundation of
   China (21577113). Professor John Hodgkiss is thanked for his assistance
   with English.
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NR 65
TC 27
Z9 29
U1 0
U2 18
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0340-5761
EI 1432-0738
J9 ARCH TOXICOL
JI Arch. Toxicol.
PD OCT
PY 2017
VL 91
IS 10
BP 3261
EP 3269
DI 10.1007/s00204-017-1961-6
PG 9
WC Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Toxicology
GA FH7QR
UT WOS:000411386000004
PM 28397090
DA 2025-06-11
ER

PT J
AU Vítek, L
AF Vitek, L.
TI Bilirubin and Atherosclerotic Diseases
SO PHYSIOLOGICAL RESEARCH
LA English
DT Review
DE Bilirubin; Atherosclerosis; Benign hyperbilirubinemia; Cardiovascular
   diseases; Gilbert syndrome
ID ISCHEMIC-HEART-DISEASE; CIRCULATING TOTAL BILIRUBIN; SERUM BILIRUBIN;
   CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; GILBERT-SYNDROME; PROMOTER
   VARIATIONS; ELEVATED BILIRUBIN; ADVANCED GLYCATION; INCREASED RISK
AB Bilirubin is the final product of heme catabolism in the systemic circulation. For decades, increased serum/plasma bilirubin levels were considered an ominous sign of an underlying liver disease. However, data from recent years convincingly suggest that mildly elevated bilirubin concentrations are associated with protection against various oxidative stress- mediated diseases, atherosclerotic conditions being the most clinically relevant. Although scarce data on beneficial effects of bilirubin had been published also in the past, it took until 1994 when the first clinical study demonstrated an increased risk of coronary heart disease in subjects with low serum bilirubin levels, and bilirubin was found to be a risk factor for atherosclerotic diseases independent of standard risk factors. Consistent with these results, we proved in our own studies, that subjects with mild elevation of serum levels of unconjugated bilirubin (benign hyperbilirubinemia, Gilbert syndrome) have much lower prevalence/ incidence of coronary heart as well as peripheral vascular disease. We have also demonstrated that this association is even more general, with serum bilirubin being a biomarker of numerous other diseases, often associated with increased risk of atherosclerosis. In addition, very recent data have demonstrated biological pathways modulated by bilirubin, which are responsible for observed strong clinical associations.
C1 [Vitek, L.] Charles Univ Prague, Fac Med 1, Dept Internal Med 4, Prague, Czech Republic.
   [Vitek, L.] Charles Univ Prague, Fac Med 1, Inst Med Biochem, Bojisti 3, Prague, Czech Republic.
   [Vitek, L.] Charles Univ Prague, Fac Med 1, Lab Diagnost, Bojisti 3, Prague, Czech Republic.
C3 Charles University Prague; Charles University Prague; Charles University
   Prague
RP Vítek, L (corresponding author), Charles Univ Prague, Fac Med 1, Inst Med Biochem, Bojisti 3, Prague, Czech Republic.; Vítek, L (corresponding author), Charles Univ Prague, Fac Med 1, Lab Diagnost, Bojisti 3, Prague, Czech Republic.
EM vitek@cesnet.cz
RI Vitek, Libor/A-2645-2008
OI Vitek, Libor/0000-0002-5318-0151
FU Ministry of Health of the Czech Republic [15-28895A]; Czech Ministry of
   Education [PRVOUK 4102280002]; Czech Ministry of Health [RVO VFN64165]
FX Supported by Ministry of Health of the Czech Republic, grant Nr.
   15-28895A, and PRVOUK 4102280002 from the Czech Ministry of Education,
   and RVO VFN64165 from the Czech Ministry of Health. All rights reserved.
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NR 78
TC 49
Z9 50
U1 1
U2 14
PU ACAD SCIENCES CZECH REPUBLIC, INST PHYSIOLOGY
PI PRAGUE 4
PA VIDENSKA 1083, PRAGUE 4 142 20, CZECH REPUBLIC
SN 0862-8408
EI 1802-9973
J9 PHYSIOL RES
JI Physiol. Res.
PY 2017
VL 66
SU 1
BP S11
EP S20
DI 10.33549/physiolres.933581
PG 10
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA ER2JS
UT WOS:000398620900003
PM 28379026
OA gold
DA 2025-06-11
ER

PT J
AU Delbridge, LMD
   Benson, VL
   Ritchie, RH
   Mellor, KM
AF Delbridge, Lea M. D.
   Benson, Vicky L.
   Ritchie, Rebecca H.
   Mellor, Kimberley M.
TI Diabetic Cardiomyopathy: The Case for a Role of Fructose in Disease
   Etiology
SO DIABETES
LA English
DT Article
ID GLYCATION END-PRODUCTS; SUGAR-SWEETENED BEVERAGES; PROTEIN
   O-GLCNACYLATION; METABOLIC SYNDROME; URIC-ACID; CARDIOVASCULAR-DISEASE;
   NONENZYMATIC GLYCATION; INSULIN-RESISTANCE; RISK-FACTORS; RAT HEARTS
AB A link between excess dietary sugar and cardiac disease is clearly evident and has been largely attributed to systemic metabolic dysregulation. Now a new paradigm is emerging, and a compelling case can be made that fructose-associated heart injury may be attributed to the direct actions of fructose on cardiomyocytes. Plasma and cardiac fructose levels are elevated in patients with diabetes, and evidence suggests that some unique properties of fructose (vs. glucose) have specific cardiomyocyte consequences. Investigations to date have demonstrated that cardiomyocytes have the capacity to transport and utilize fructose and express all of the necessary proteins for fructose metabolism. When dietary fructose intake is elevated and myocardial glucose uptake compromised by insulin resistance, increased cardiomyocyte fructose flux represents a hazard involving unregulated glycolysis and oxidative stress. The high reactivity of fructose supports the contention that fructose accelerates subcellular hexose sugar-related protein modifications, such as O-GIcNAcylation and advanced glycation end product formation. Exciting recent discoveries link heart failure to induction of the specific high-affinity fructose-metabolizing enzyme, fructokinase, in an experimental setting. In this Perspective, we review key recent findings to synthesize a novel view of fructose as a cardiopathogenic agent in diabetes and to identify important knowledge gaps for urgent research focus.
C1 [Delbridge, Lea M. D.; Mellor, Kimberley M.] Univ Melbourne, Dept Physiol, Melbourne, Vic, Australia.
   [Benson, Vicky L.; Mellor, Kimberley M.] Univ Auckland, Dept Physiol, Auckland, New Zealand.
   [Ritchie, Rebecca H.] Baker IDI Heart & Diabet Inst, Heart Failure Pharmacol, Melbourne, Vic, Australia.
   [Mellor, Kimberley M.] Univ Auckland, Auckland Bioengn Inst, Auckland, New Zealand.
C3 University of Melbourne; University of Auckland; Baker Heart and
   Diabetes Institute; University of Auckland
RP Delbridge, LMD (corresponding author), Univ Melbourne, Dept Physiol, Melbourne, Vic, Australia.
EM lmd@unimelb.edu.au
RI Ritchie, Rebecca/E-7392-2011
OI Ritchie, Rebecca/0000-0002-8610-0058; Mellor,
   Kimberley/0000-0002-8443-9365
FU Diabetes Australia Research Trust
FX We acknowledge Brendan Ma from the University of Melbourne and Andrew
   Lim from the University of Auckland for their assistance in the early
   stages of literature compilation for manuscript development. We
   acknowledge funding support from the Diabetes Australia Research Trust.
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NR 68
TC 40
Z9 44
U1 0
U2 17
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0012-1797
EI 1939-327X
J9 DIABETES
JI Diabetes
PD DEC
PY 2016
VL 65
IS 12
BP 3521
EP 3528
DI 10.2337/db16-0682
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA EE0RA
UT WOS:000389285400001
PM 27879401
OA Bronze
DA 2025-06-11
ER

PT J
AU Laish, I
   Mannasse-Green, B
   Hadary, R
   Biron-Shental, T
   Konikoff, FM
   Amiel, A
   Kitay-Cohen, Y
AF Laish, Ido
   Mannasse-Green, Batya
   Hadary, Ruth
   Biron-Shental, Tal
   Konikoff, Fred M.
   Amiel, Aliza
   Kitay-Cohen, Yona
TI Telomere Dysfunction in Nonalcoholic Fatty Liver Disease and Cryptogenic
   Cirrhosis
SO CYTOGENETIC AND GENOME RESEARCH
LA English
DT Article
DE Cryptogenic cirrhosis; Fatty liver; Fluorescence in situ hybridization;
   Telomeres
ID CELLULAR SENESCENCE; METABOLIC SYNDROME; OXIDATIVE STRESS;
   GENE-EXPRESSION; NATURAL-HISTORY; IMMORTAL CELLS; DNA-DAMAGE;
   STEATOHEPATITIS; LENGTH; CAPTURE
AB Nonalcoholic fatty liver disease (NAFLD) and cryptogenic cirrhosis (CC) are considered preneoplastic conditions that might progress to hepatocellular carcinoma. We evaluated parameters of telomere dysfunction in these patient groups to study the correlation between telomere length and the progression of NAFLD. We analyzed peripheral lymphocytes from 22 patients with NAFLD, 20 patients with CC, and 20 healthy, age-matched controls. Telomere length was analyzed using quantitative fluorescence in situ hybridization, and cellular senescence was evaluated by the percentage of cells with senescence-associated heterochromatin foci. The expression of telomerase reverse transcriptase (hTERT) mRNA was measured using polymerase chain reaction, and telomere capture (TC) was assessed with 2 Cytocell probes, 15qter and 13qter. Shorter telomere length and increased cellular senescence was demonstrated in patients with NAFLD, compared to the CC patients and healthy controls. While hTERT mRNA was significantly decreased, TC was increased in CC patients, compared to the NAFLD group and healthy individuals. Thus, there is a correlation between hTERT mRNA expression and telomere length in patients with NAFLD, which might be related to associated metabolic disorders and the risk of malignant transformation. Patients with CC, on the contrary, elongate their telomeres through the TC mechanism. (C) 2016 S. Karger AG, Basel
C1 [Laish, Ido; Konikoff, Fred M.] Meir Med Ctr, Gastroenterol & Hepatol Inst, 59 Tschernihovsky St, IL-44281 Kefar Sava, Israel.
   [Mannasse-Green, Batya; Amiel, Aliza] Meir Med Ctr, Genet Inst, Kefar Sava, Israel.
   [Hadary, Ruth; Kitay-Cohen, Yona] Meir Med Ctr, Liver Unit, Kefar Sava, Israel.
   [Biron-Shental, Tal] Meir Med Ctr, Dept Obstet & Gynecol, Kefar Sava, Israel.
   [Laish, Ido; Hadary, Ruth; Biron-Shental, Tal; Konikoff, Fred M.; Kitay-Cohen, Yona] Tel Aviv Univ, Sackler Sch Med, Tel Aviv, Israel.
   [Amiel, Aliza] Bar Ilan Univ, Fac Life Sci, Ramat Gan, Israel.
C3 Tel Aviv University; Sackler Faculty of Medicine; Tel Aviv University;
   Sackler Faculty of Medicine; Tel Aviv University; Sackler Faculty of
   Medicine; Tel Aviv University; Sackler Faculty of Medicine; Tel Aviv
   University; Sackler Faculty of Medicine; Bar Ilan University
RP Laish, I (corresponding author), Meir Med Ctr, Gastroenterol & Hepatol Inst, 59 Tschernihovsky St, IL-44281 Kefar Sava, Israel.
EM ido.laish@gmail.com
RI Biron-Shental, Tal/L-6035-2019
FU Josefina Maus and Gabriela Cesarman Chair for Research in Liver
   Diseases, the Tel Aviv University
FX This study was supported in part by the Josefina Maus and Gabriela
   Cesarman Chair for Research in Liver Diseases, the Tel Aviv University.
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NR 39
TC 38
Z9 38
U1 0
U2 5
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1424-8581
EI 1424-859X
J9 CYTOGENET GENOME RES
JI Cytogenet. Genome Res.
PY 2016
VL 150
IS 2
BP 93
EP 99
DI 10.1159/000454654
PG 7
WC Cell Biology; Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Genetics & Heredity
GA EL9XA
UT WOS:000394972200003
PM 28006764
DA 2025-06-11
ER

PT J
AU Swaminathan, A
   Jicha, GA
AF Swaminathan, Arun
   Jicha, Gregory A.
TI Nutrition and prevention of Alzheimer's dementia
SO FRONTIERS IN AGING NEUROSCIENCE
LA English
DT Review
DE nutrition; Alzheimer; treatment; clinical trial; prevention
ID COGNITIVE DECLINE; MEDITERRANEAN DIET; METABOLIC SYNDROME; DOUBLE-BLIND;
   VITAMIN-E; VASCULAR DEMENTIA; OXIDATIVE STRESS; CONTROLLED-TRIAL;
   CLINICAL-TRIAL; GINKGO-BILOBA
AB A nutritional approach to prevent, slow, or halt the progression of disease is a promising strategy that has been widely investigated. Much epidemiologic data suggests that nutritional intake may influence the development and progression of Alzheimer's dementia (AD). Modifiable, environmental causes of AD include potential metabolic derangements caused by dietary insufficiency and or excess that may be corrected by nutritional supplementation and ordietary modification. Many nutritional supplements contain a myriad of health promoting constituents (anti-oxidants, vitamins, traceminerals, flavonoids, lipids,... etc.) that may have novel mechanisms of action affecting cellular health and regeneration, the aging process itself, or may specifically disrupt pathogenic pathways in the development of AD. Nutritional modifications have the advantage of being costeffective, easy to implement, socially acceptable and generally safe and devoid of significant adverse events in mostcases. Many nutritional interventions have been studied and continue to be evaluated in hopes of finding a successful agent, combination of agents, ordietary modifications that can be used for the prevention and or treatment of AD. The current review focuses on several key nutritional compounds and dietary modifications that have been studied in humans, and further discusses the rationale underlying their potential utility for the prevention and treatment of AD.
C1 [Jicha, Gregory A.] Univ Kentucky, Coll Med, Dept Neurol, Lexington, KY 40536 USA.
   Univ Kentucky, Coll Med, Sanders Brown Ctr Aging, Lexington, KY 40536 USA.
C3 University of Kentucky; University of Kentucky
RP Jicha, GA (corresponding author), Univ Kentucky, Coll Med, Dept Neurol, Lexington, KY 40536 USA.
EM gregory.jicha@uky.edu
OI Jicha, Gregory/0000-0002-7980-2166; Swaminathan,
   Arun/0000-0002-3353-6069
FU NIH [R01 AG042419, R01 NR014189, U01 AG010483, P30 AG028383, R01
   AG019241, R01 HD064993, R01 AG038651, UL1 TR000117]; Eli Lilly; Esai;
   Pfizer; Toyama
FX The authors wish to thank the many investigators, dedicated research
   participants, and funding sources that have contributed to the
   scientific research of nutritional interventions for the prevention of
   AD. We apologize to the many researchers who have contributed to the
   field and have not been cited herein. Dr. Swaminathan has nothing to
   disclose. Dr. Jicha served as study investigator on the NIH/NIA-funded
   Alzheimer Cooperative Study Group investigations of DHA (Quinn et al.,
   2010), Antioxidants (Galasko et al., 2012), and Resveratrol
   (NCT01504854), as well as the NIH/NIA-funded PreADViSE study (Kryscio et
   al., 2013), and the industry-sponsored S-CONNECT study of Souvenaid (R)
   (Shah et al., 2013) included in this review. Dr. Jicha is funded by NIH
   R01 AG042419, R01 NR014189, U01 AG010483, P30 AG028383, R01 AG019241,
   R01 HD064993, R01 AG038651, UL1 TR000117, and is currently receiving
   contract research funding from Eli Lilly, Esai, Pfizer, and Toyama.
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NR 88
TC 68
Z9 73
U1 0
U2 83
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1663-4365
J9 FRONT AGING NEUROSCI
JI Front. Aging Neurosci.
PD OCT 20
PY 2014
VL 6
AR 282
DI 10.3389/fnagi.2014.00282
PG 13
WC Geriatrics & Gerontology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology; Neurosciences & Neurology
GA AY9MD
UT WOS:000347874300001
PM 25368575
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Song, SY
   Jung, EC
   Bae, CH
   Choi, YS
   Kim, YD
AF Song, Si-Youn
   Jung, Eun Chae
   Bae, Chang Hoon
   Choi, Yoon Seok
   Kim, Yong-Dae
TI Visfatin induces MUC8 and MUC5B expression via p38 MAPK/ROS/NF-κB in
   human airway epithelial cells
SO JOURNAL OF BIOMEDICAL SCIENCE
LA English
DT Article
DE Visfatin; p38 MAPK; ROS; NF-kappa B; MUC8; MUC5B; Epithelial cell
ID OXIDATIVE STRESS; MMP-2/9 PRODUCTION; ENDOTHELIAL-CELLS; MAPK;
   ACTIVATION; PATHWAY; PROTEIN
AB Background: Among a variety of inflammatory mediators, visfatin is a proinflammatory adipocytokine associated with inflammatory reactions in obesity, metabolic syndrome, chronic inflammatory disease, and autoimmune disease. However, the biological role of visfatin in secretion of major mucins in human airway epithelial cells has not been reported. Therefore, this study was conducted in order to investigate the effect and the brief signaling pathway of visfatin on MUC8 and MUC5B expression in human airway epithelial cells.
   Results: Visfatin significantly induced MUC8 and MUC5B expression. Visfatin significantly activated phosphorylation of p38 MAPK. Treatment with SB203580 (p38 MAPK inhibitor) and knockdown of p38 MAPK by siRNA significantly blocked visfatin-induced MUC8 and MUC5B expression. Visfatin significantly increased ROS formation. Treatment with SB203580 significantly attenuated visfatin-induced ROS formation. Treatment with NAC (ROS scavenger) and DPI (NADPH oxidase inhibitor) significantly attenuated visfatin-induced MUC8 and MUC5B expression. However, treatment with NAC and DPI did not attenuate visfatin-activated phosphorylation of p38 MAPK. Visfatin significantly activated the phosphorylation of NF-kappa B. Treatment with PDTC (NF-kappa B inhibitor) significantly attenuated visfatin-induced MUC8 and MUC5B expression.
   Conclusions: These results suggest that visfatin induces MUC8 and MUC5B expression through p38 MAPK/ROS/NF-kappa B signaling pathway in human airway epithelial cells.
C1 [Song, Si-Youn; Jung, Eun Chae; Bae, Chang Hoon; Choi, Yoon Seok; Kim, Yong-Dae] Yeungnam Univ, Coll Med, Dept Otorhinolaryngol Head & Neck Surg, Taegu, South Korea.
   [Kim, Yong-Dae] Yeungnam Univ, Coll Med, Reg Ctr Resp Dis, Taegu, South Korea.
C3 Yeungnam University; Yeungnam University
RP Kim, YD (corresponding author), Yeungnam Univ, Coll Med, Dept Otorhinolaryngol Head & Neck Surg, Taegu, South Korea.
EM ydkim@med.yu.ac.kr
RI Choi, Yoon Seok/JXL-3789-2024; Kim, Yong/AAX-2487-2021
FU Yeungnam University
FX This work was supported by the 2013 Yeungnam University Research Grant.
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Z9 28
U1 0
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PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
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EI 1423-0127
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PD MAY 20
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DI 10.1186/1423-0127-21-49
PG 9
WC Cell Biology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Research & Experimental Medicine
GA AI4UW
UT WOS:000336861300001
PM 24885580
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Ortega, FJ
   Fernández-Real, JM
AF Ortega, F. J.
   Fernandez-Real, J. M.
TI Inflammation in Adipose Tissue and Fatty Acid Anabolism: When Enough is
   Enough!
SO HORMONE AND METABOLIC RESEARCH
LA English
DT Review
DE adipogenesis; lipogenesis; obesity; cell senescence; macrophages;
   lymphocytes; adipokines
ID DE-NOVO LIPOGENESIS; MONOCYTE CHEMOATTRACTANT PROTEIN-1; NF-KAPPA-B;
   INSULIN-RESISTANCE; GENE-EXPRESSION; NITRIC-OXIDE; METABOLIC SYNDROME;
   OXIDATIVE STRESS; INNATE IMMUNITY; SYNTHASE GENE
AB Recent findings in adipose tissue (AT) have uncovered negative interactions among obesity, lipogenesis, and fatty acid (FA) storage, perhaps in response to the increased production of proinflammatory cytokines and transcription factors. Emerging evidence highlights that local hypoxia, generation of reactive oxygen and nitrogen species, increased immune cells infiltration and activation, senescence, inflammation, energy consumption, and decreased lipogenesis in the AT are interrelated and may lead to impaired cytokine and hormonal secretion by adipocytes, and ectopic fat deposition in obesity that strengths the increased risk of suffering metabolic disorders in obese subjects. The information summarized in this review attempts to defend the interdependent relationship of these proofs of concept, supporting the idea that inflamed and dysfunctional AT are synonymous when referring to obesity. This may happen in severe obese subjects with a large and long-lasting fat excess, when fat depots have reached the point in which excessive fat storage, cell density, and diminished oxygen availability promote decreased lipo/adipogenesis and increased lipolysis and FA release. This response may be induced by an important inflammatory component that promotes angiogenesis and insulin resistance, but also by leptin and the increase of T-3 in hyperplastic AT.
C1 [Ortega, F. J.; Fernandez-Real, J. M.] Inst Invest Biomed Girona IdIBGi, Dept Diabet Endocrinol & Nutr UDEN, Girona, Spain.
   [Ortega, F. J.; Fernandez-Real, J. M.] CIBER Fisiopatol Obesidad & Nutr CIBERobn CB06 03, Santiago De Compostela, Spain.
   [Ortega, F. J.; Fernandez-Real, J. M.] ISCIII, Santiago De Compostela, Spain.
C3 Universitat de Girona; Girona University Hospital Dr. Josep Trueta;
   Institut d'Investigacio Biomedica de Girona (IDIBGI); CIBER - Centro de
   Investigacion Biomedica en Red; CIBEROBN; Instituto de Salud Carlos III
RP Ortega, FJ (corresponding author), Hosp Dr Josep Trueta Girona, Inst Invest Biomed Girona IdIBGi, Sect Diabet Endocrinol & Nutr UDEN, Carretera Franca S-N, Girona 17007, Spain.
EM fortega@idibgi.org; jmfreal@idibgi.org
RI Fernández-Real, Jose Manuel/AGH-3599-2022; Ortega, Francisco
   Jose/F-3883-2016
OI Ortega, Francisco Jose/0000-0003-2111-769X; Fernandez-Real, Jose
   Manuel/0000-0002-7442-9323
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NR 150
TC 15
Z9 18
U1 0
U2 14
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0018-5043
EI 1439-4286
J9 HORM METAB RES
JI Horm. Metab. Res.
PD DEC
PY 2013
VL 45
IS 13
BP 1009
EP 1019
DI 10.1055/s-0033-1358690
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 269KW
UT WOS:000328241200013
PM 24277504
DA 2025-06-11
ER

PT J
AU Shen, XY
   Miao, S
   Zhang, YP
   Guo, XY
   Li, WX
   Mao, X
   Zhang, QS
AF Shen, Xinyi
   Miao, Shuo
   Zhang, Yaping
   Guo, Xingying
   Li, Wenxian
   Mao, Xin
   Zhang, Qingsong
TI Stearic acid metabolism in human health and disease
SO CLINICAL NUTRITION
LA English
DT Review
DE Stearic acid; Metabolic syndrome; Cardiovascular diseases; Cancer;
   Neurodegenerative diseases
ID INFLUENZA-VIRUS HEMAGGLUTININ; CORONARY-HEART-DISEASE; SATURATED
   FATTY-ACIDS; ENDOPLASMIC-RETICULUM STRESS; ACTIVATED RECEPTORS PPARS;
   SITE-SPECIFIC ATTACHMENT; BREAST-CANCER PATIENTS; WHITE ADIPOSE-TISSUE;
   OLEIC-ACID; CELL-DEATH
AB Named after the Greek term for "hard fat", stearic acid has gradually entered people's field of vision. As an important component of various physiological cellular functions, stearic acid plays a regulatory role in diverse aspects of energy metabolism and signal transduction. Its applications range from serving as a bodily energy source to participating in endogenous biosynthesis. Similar to palmitate, stearic acid serves as a primary substrate for the stearoyl coenzyme A desaturase, which catalyzes the conversion of stearate to oleate and is involved in the synthesis of triglyceride and other complex lipids. Additionally, stearic acid functions as a vital signaling molecule in pathological processes such as cardiovascular diseases, diabetes development, liver injury and even nervous system disorders. Therefore, we conduct a comprehensive review of stearic acid, summarizing its role in various diseases and attempting to provide a systematic overview of its homeostasis, physiological functions, and pathological process. From a medical standpoint, we also explore potential applications and discuss stearic acid as a potential therapeutic target for the treatment of human diseases. (c) 2024 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights are reserved, including those for text and data mining, AI training, and similar technologies.
C1 [Shen, Xinyi; Li, Wenxian; Mao, Xin; Zhang, Qingsong] Qingdao Univ, Dept Urol, Affiliated Hosp, Qingdao, Peoples R China.
   [Shen, Xinyi; Miao, Shuo] Qingdao Univ, Sch Basic Med, Qingdao, Peoples R China.
   [Zhang, Yaping; Guo, Xingying] Qingdao Univ, Dept Operating Room, Affiliated Hosp, Qingdao, Peoples R China.
C3 Qingdao University; Qingdao University; Qingdao University
RP Mao, X; Zhang, QS (corresponding author), Qingdao Univ, Dept Urol, Affiliated Hosp, Qingdao, Peoples R China.
EM XMsubmit@163.com; Qingsong3333@163.com
RI Li, Wenxian/JNT-2127-2023
FU National Science Foundation [82100285]
FX This work was supported by the National Science Foundation (Project No.
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NR 314
TC 0
Z9 0
U1 13
U2 13
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0261-5614
EI 1532-1983
J9 CLIN NUTR
JI Clin. Nutr.
PD JAN
PY 2025
VL 44
BP 222
EP 238
DI 10.1016/j.clnu.2024.12.012
EA DEC 2024
PG 17
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA R7C8T
UT WOS:001392994300001
PM 39709650
DA 2025-06-11
ER

PT J
AU Meier, DT
   Souza, JD
   Donath, MY
AF Meier, Daniel T.
   Souza, Joyce de Paula
   Donath, Marc Y.
TI Targeting the NLRP3 inflammasome-IL-1β pathway in type 2 diabetes and
   obesity
SO DIABETOLOGIA
LA English
DT Review
DE Clinical study; Diabetes; IL-1 beta; Inflammasome; Inflammation;
   Insulin; NLRP3; Obesity; Pancreatic islet; Review
ID IL-1 RECEPTOR ANTAGONIST; INSULIN-SECRETION; INTERLEUKIN-1 FAMILY;
   DOUBLE-BLIND; INFLAMMATORY CYTOKINES; METABOLIC SYNDROME; ELEVATED
   LEVELS; WEIGHT-LOSS; BETA-CELLS; IL-1-BETA
AB Increased activity of the NACHT, LRR and PYD domains-containing protein 3 (NLRP3) inflammasome-IL-1 beta pathway is observed in obesity and contributes to the development of type 2 diabetes and its complications. In this review, we describe the pathological activation of IL-1 beta by metabolic stress, ageing and the microbiome and present data on the role of IL-1 beta in metabolism. We explore the physiological role of the IL-1 beta pathway in insulin secretion and the relationship between circulating levels of IL-1 beta and the development of diabetes and associated diseases. We highlight the paradoxical nature of IL-1 beta as both a friend and a foe in glucose regulation and provide details on clinical translation, including the glucose-lowering effects of IL-1 antagonism and its impact on disease modification. We also discuss the potential role of IL-1 beta in obesity, Alzheimer's disease, fatigue, gonadal dysfunction and related disorders such as rheumatoid arthritis and gout. Finally, we address the safety of NLRP3 inhibition and IL-1 antagonists and the prospect of using this therapeutic approach for the treatment of type 2 diabetes and its comorbidities.
C1 [Meier, Daniel T.; Souza, Joyce de Paula; Donath, Marc Y.] Univ Hosp Basel, Clin Endocrinol Diabet & Metab, Basel, Switzerland.
   [Meier, Daniel T.; Souza, Joyce de Paula; Donath, Marc Y.] Univ Basel, Dept Biomed, Basel, Switzerland.
C3 University of Basel; University of Basel
RP Meier, DT; Donath, MY (corresponding author), Univ Hosp Basel, Clin Endocrinol Diabet & Metab, Basel, Switzerland.; Meier, DT; Donath, MY (corresponding author), Univ Basel, Dept Biomed, Basel, Switzerland.
EM daniel.zeman@unibas.ch; marc.donath@usb.ch
FU University of Basel; Swiss National Science Foundation [214900, 212319];
   European Union - Horizon/Swiss State Secretariat for Education, Research
   and Innovation [101095433]; Academy of Finland (AKA) [212319] Funding
   Source: Academy of Finland (AKA); Horizon Europe - Pillar II [101095433]
   Funding Source: Horizon Europe - Pillar II
FX Open access funding provided by University of Basel. Work in the
   authors' laboratories is supported by the Swiss National Science
   Foundation (214900 and 212319) and the European Union - Horizon/Swiss
   State Secretariat for Education, Research and Innovation (101095433).
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NR 141
TC 4
Z9 4
U1 8
U2 10
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0012-186X
EI 1432-0428
J9 DIABETOLOGIA
JI Diabetologia
PD JAN
PY 2025
VL 68
IS 1
BP 3
EP 16
DI 10.1007/s00125-024-06306-1
EA NOV 2024
PG 14
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA Q0W2V
UT WOS:001347884100002
PM 39496966
OA hybrid
DA 2025-06-11
ER

PT J
AU Picatoste, B
   Cerro-Pardo, I
   Blanco-Colio, LM
   Martín-Ventura, JL
AF Picatoste, Belen
   Cerro-Pardo, Isabel
   Blanco-Colio, Luis M.
   Martin-Ventura, Jose L.
TI Protection of diabetes in aortic abdominal aneurysm: Are antidiabetics
   the real effectors?
SO FRONTIERS IN CARDIOVASCULAR MEDICINE
LA English
DT Review
DE abdominal aortic aneursym; diabet mellitus; insulin resistance; obesity;
   antidiabetic drugs
ID GLUCAGON-LIKE PEPTIDE-1; ALL-CAUSE MORTALITY; PERIPHERAL
   ARTERIAL-DISEASE; BASEMENT-MEMBRANE PROTEINS; METABOLIC SYNDROME;
   ENDOTHELIAL DYSFUNCTION; CARDIOVASCULAR OUTCOMES;
   CEREBROVASCULAR-DISEASE; VASCULAR COMPLICATIONS; INSULIN-RESISTANCE
AB Aortic aneurysms, including abdominal aortic aneurysms (AAAs), is the second most prevalent aortic disease and represents an important cause of death worldwide. AAA is a permanent dilation of the aorta on its infrarenal portion, pathologically associated with oxidative stress, proteolysis, vascular smooth muscle cell loss, immune-inflammation, and extracellular matrix remodeling and degradation. Most epidemiological studies have shown a potential protective role of diabetes mellitus (DM) on the prevalence and incidence of AAA. The effect of DM on AAA might be explained mainly by two factors: hyperglycemia [or other DM-related factors such as insulin resistance (IR)] and/or by the effect of prescribed DM drugs, which may have a direct or indirect effect on the formation and progression of AAAs. However, recent studies further support that the protective role of DM in AAA may be attributable to antidiabetic therapies (i.e.: metformin or SGLT-2 inhibitors). This review summarizes current literature on the relationship between DM and the incidence, progression, and rupture of AAAs, and discusses the potential cellular and molecular pathways that may be involved in its vascular effects. Besides, we provide a summary of current antidiabetic therapies which use could be beneficial for AAA.
C1 [Picatoste, Belen; Cerro-Pardo, Isabel; Blanco-Colio, Luis M.; Martin-Ventura, Jose L.] Fdn Jimenez Diaz, Lab Vasc Pathol, IIS, Madrid, Spain.
   [Picatoste, Belen] Alfonso X El Sabio Univ, Biomed Dept, Madrid, Spain.
   [Blanco-Colio, Luis M.; Martin-Ventura, Jose L.] CIBERCV, Madrid, Spain.
   [Martin-Ventura, Jose L.] Univ Autonoma Madrid, Med Dept, Madrid, Spain.
C3 Fundacion Jimenez Diaz; Universidad Alfonso X el Sabio (UAX); CIBER -
   Centro de Investigacion Biomedica en Red; CIBERCV; Autonomous University
   of Madrid
RP Picatoste, B (corresponding author), Fdn Jimenez Diaz, Lab Vasc Pathol, IIS, Madrid, Spain.; Picatoste, B (corresponding author), Alfonso X El Sabio Univ, Biomed Dept, Madrid, Spain.
EM maria.picatoste@quironsalud.es
RI MARTIN-VENTURA, JOSE/Z-2386-2019; Blanco-Colio, Luis/Z-2390-2019
OI Blanco-Colio, Luis Miguel/0000-0002-1560-6609; Cerro Pardo,
   Isabel/0000-0002-2542-5051
FU Spanish MINECO [PID2019-106814RB-I00]; "la Caixa" Banking Foundation
   [HR22-00253]; Comunidad de Madrid [P2022/BMD-7333]
FX Funding This study was funded by the Spanish MINECO
   (PID2019-106814RB-I00), "la Caixa" Banking Foundation (HR22-00253) and
   Comunidad de Madrid (P2022/BMD-7333, INMUNOVAR-CM).
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NR 157
TC 9
Z9 9
U1 0
U2 3
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2297-055X
J9 FRONT CARDIOVASC MED
JI Front. Cardiovasc. Med.
PD MAR 23
PY 2023
VL 10
AR 1112430
DI 10.3389/fcvm.2023.1112430
PG 12
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA C6RU4
UT WOS:000963173900001
PM 37034348
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Yang, X
   Zhou, HB
   Zhang, H
   Zhang, PJ
   Zheng, ZK
   Xu, DL
   Zeng, QC
AF Yang, Xi
   Zhou, Haobin
   Zhang, Hao
   Zhang, Peijian
   Zheng, Zhikang
   Xu, Dingli
   Zeng, Qingchun
TI Association between urinary biomarkers of polycyclic aromatic
   hydrocarbons and severe abdominal aortic calcification in adults: data
   from the National Health and Examination Nutrition Survey
SO BMC CARDIOVASCULAR DISORDERS
LA English
DT Article
DE Abdominal aortic calcification; PAHs exposure; NHANES; Logistic
   regression
ID VASCULAR CALCIFICATION; METABOLIC SYNDROME; OXIDATIVE STRESS; PAH
   EXPOSURE; 1-HYDROXYPYRENE; DISEASE; MORBIDITY; MORTALITY; MARKERS
AB ObjectiveRecent studies have found that polycyclic aromatic hydrocarbons (PAHs) exposure may increase the risk of cardiovascular disease. The present study aimed to explore the association between PAHs exposure and severe abdominal aortic calcification (AAC) in adults.MethodsData were collected from the 2013-2014 National Health and Nutrition Examination Survey. PAHs exposure was analyzed from urinary mono hydroxylated metabolites of PAHs. Logistic regression models and subgroup analysis were performed to explore the association of PAHs exposure with severe AAC prevalence.ResultsA total of 1,005 eligible individuals were recruited into the study. After adjusting for confounding factors, those with the highest quartiles of 1-hydroxynaphthalene (1-NAP: OR 2.19, 95% CI 1.03-4.68, P-for trend < 0.001), 2-hydroxynaphthalene (2-NAP: OR 2.22, 95% CI 1.04-4.64, P-for trend < 0.001) and 1-hydroxypyrene (1-PYR: OR 2.15, 95% CI 1.06-4.33, P-for trend < 0.001) were associated with an increased prevalence of severe AAC in the adults compared to those who in the lowest quartile.ConclusionThis study found that urinary 1-NAP, 2-NAP and 1-PYR were positively associated with severe AAC prevalence in adults.
C1 [Yang, Xi; Zhang, Hao; Zheng, Zhikang; Xu, Dingli; Zeng, Qingchun] Southern Med Univ, Nanfang Hosp, Dept Cardiol, State Key Lab Organ Failure Res, 1838 Northern Guangzhou Ave, Guangzhou 510515, Peoples R China.
   [Zhou, Haobin] Guangzhou Med Univ, Affiliated Hosp 1, Dept Cardiol, Guangzhou 510120, Guangdong, Peoples R China.
   [Zhang, Peijian] Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Cardiovasc Med Dept, Guangzhou 510120, Peoples R China.
C3 Southern Medical University - China; Guangzhou Medical University; Sun
   Yat Sen University
RP Xu, DL; Zeng, QC (corresponding author), Southern Med Univ, Nanfang Hosp, Dept Cardiol, State Key Lab Organ Failure Res, 1838 Northern Guangzhou Ave, Guangzhou 510515, Peoples R China.
EM dlxugz@163.com; qingchunzeng@smu.edu.cn
RI Xu, Dingli/AAA-6176-2019
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NR 46
TC 5
Z9 5
U1 2
U2 19
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1471-2261
J9 BMC CARDIOVASC DISOR
JI BMC Cardiovasc. Disord.
PD FEB 23
PY 2023
VL 23
IS 1
AR 104
DI 10.1186/s12872-023-03122-0
PG 8
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 9F4WJ
UT WOS:000937470200001
PM 36823527
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Pakpahan, C
   Rezano, A
   Margiana, R
   Amanda, B
   Agustinus, A
   Darmadi, D
AF Pakpahan, Cennikon
   Rezano, Andri
   Margiana, Ria
   Amanda, Bella
   Agustinus, Agustinus
   Darmadi, Darmadi
TI The Association Between Lipid Serum and Semen Parameters: a Systematic
   Review
SO REPRODUCTIVE SCIENCES
LA English
DT Review
DE Lipid serum; Sperm motility; Sperm morphology; Sperm concentration;
   Reproductive health care; Male infertility
ID METABOLIC SYNDROME; OXIDATIVE STRESS; MALE-INFERTILITY; SEMINAL PLASMA;
   HORMONE-LEVELS; QUALITY; MEN; CHOLESTEROL; SPERM; STEROIDOGENESIS
AB Increased lipid levels sometimes not only affect sexual function but also are considered to harm semen quality. It is often a suspicion that elevated lipids are a factor in infertility. We conduct a systematic review. Articles that met the criteria were identified according to The Preferred Reporting Items for Systematic Review and Meta-analysis of recommendations in the PubMed, ProQuest, EBSCO, Web of Science Wiley Online, Springer Link, Scopus, and Science Direct databases with no time restriction for publication. Seven studies are eligible for qualitative analysis from nine studies that have the potential to be assessed. These studies measure the correlation of serum lipids (VLDL, HDL, LDL, triglycerides, total cholesterol, free cholesterol, phospholipids, free fatty acids) with semen parameters (concentration, motility, morphology, DNA fragmentation index). Although not all studies consistently report that lipids impact semen quality, this review suspects that lipids have a significant impact on sperm quality. This study implies that it is necessary to maintain lipid levels to maintain sperm quality and quality of life. However, further investigation with an observational cohort study design needs to be carried out to assess the effect of lipids on semen quality more precisely for the promotion of reproductive health care.
C1 [Pakpahan, Cennikon; Rezano, Andri; Margiana, Ria; Amanda, Bella; Agustinus, Agustinus] Univ Airlangga, Fac Med, Androl Study Program, Surabaya, Indonesia.
   [Pakpahan, Cennikon; Amanda, Bella; Agustinus, Agustinus] Univ Airlangga, Fac Med, Dept Biomed Sci, Jl Mayjen Prof Dr Moestopo 47, Surabaya 60131, Indonesia.
   [Rezano, Andri] Univ Padjadjaran, Fac Med, Dept Biomed Sci, Sumedang, Indonesia.
   [Margiana, Ria] Univ Indonesia, Fac Med, Dept Anat, Jakarta, Indonesia.
   [Darmadi, Darmadi] Univ Sumatera Utara, Fac Med, Dept Internal Med, Medan, Indonesia.
C3 Airlangga University; Airlangga University; Universitas Padjadjaran;
   University of Indonesia; University of North Sumatra
RP Pakpahan, C (corresponding author), Univ Airlangga, Fac Med, Dept Biomed Sci, Jl Mayjen Prof Dr Moestopo 47, Surabaya 60131, Indonesia.
EM cennikon.pakpahan@fk.unair.ac.id
RI Rezano, Andri/AAU-5714-2021; Amanda, Bella/IZD-4554-2023; Pakpahan,
   Cennikon/ADD-1707-2022; Darmadi, Darmadi/AAN-1197-2020
OI Margiana, Ria/0009-0003-0632-5578; Pakpahan,
   Cennikon/0000-0003-0157-1131; , DARMADI/0000-0001-5281-168X; Margiana,
   Ria/0000-0002-6747-0117; Rezano, Andri/0000-0003-2550-8794; Margiana,
   Ria/0000-0003-2339-1748; Amanda, Bella/0000-0001-5666-367X
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NR 63
TC 12
Z9 13
U1 0
U2 6
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1933-7191
EI 1933-7205
J9 REPROD SCI
JI Reprod. Sci.
PD MAR
PY 2023
VL 30
IS 3
BP 761
EP 771
DI 10.1007/s43032-022-01040-8
EA JUL 2022
PG 11
WC Obstetrics & Gynecology; Reproductive Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology; Reproductive Biology
GA A1WL0
UT WOS:000832552200001
PM 35902546
DA 2025-06-11
ER

PT J
AU Blázquez, E
   Hurtado-Carneiro, V
   LeBaut-Ayuso, Y
   Velázquez, E
   García-García, L
   Gómez-Oliver, F
   Ruiz-Albusac, JM
   Avila, J
   Pozo, MA
AF Blazquez, Enrique
   Hurtado-Carneiro, Veronica
   LeBaut-Ayuso, Yannick
   Velazquez, Esther
   Garcia-Garcia, Luis
   Gomez-Oliver, Francisca
   Miguel Ruiz-Albusac, Juan
   Avila, Jesus
   Angel Pozo, Miguel
TI Significance of Brain Glucose Hypometabolism, Altered Insulin Signal
   Transduction, and Insulin Resistance in Several Neurological Diseases
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Review
DE brain; glucose hypometabolism; altered insulin signaling; insulin
   resistance; neurological disorders
ID AMYLOID PRECURSOR PROTEIN; GLYCOGEN-SYNTHASE KINASE-3; MILD COGNITIVE
   IMPAIRMENT; TRANSGENIC MOUSE MODEL; ALZHEIMERS-DISEASE;
   PARKINSONS-DISEASE; HUNTINGTONS-DISEASE; METABOLIC SYNDROME;
   DIABETES-MELLITUS; GLP-1 RECEPTOR
AB Several neurological diseases share pathological alterations, even though they differ in their etiology. Neuroinflammation, altered brain glucose metabolism, oxidative stress, mitochondrial dysfunction and amyloidosis are biological events found in those neurological disorders. Altered insulin-mediated signaling and brain glucose hypometabolism are characteristic signs observed in the brains of patients with certain neurological diseases, but also others such as type 2 diabetes mellitus and vascular diseases. Thus, significant reductions in insulin receptor autophosphorylation and Akt kinase activity, and increased GSK-3 activity and insulin resistance, have been reported in these neurological diseases as contributing to the decline in cognitive function. Supporting this relationship is the fact that nasal and hippocampal insulin administration has been found to improve cognitive function. Additionally, brain glucose hypometabolism precedes the unmistakable clinical manifestations of some of these diseases by years, which may become a useful early biomarker. Deficiencies in the major pathways of oxidative energy metabolism have been reported in patients with several of these neurological diseases, which supports the hypothesis of their metabolic background. This review remarks on the significance of insulin and brain glucose metabolism alterations as keystone common pathogenic substrates for certain neurological diseases, highlighting new potential targets.
C1 [Blazquez, Enrique; LeBaut-Ayuso, Yannick; Velazquez, Esther; Miguel Ruiz-Albusac, Juan] Univ Complutense Madrid, Fac Med, Dept Biochem & Mol Biol, Madrid, Spain.
   [Hurtado-Carneiro, Veronica; Angel Pozo, Miguel] Univ Complutense Madrid, Fac Med, Dept Physiol, Madrid, Spain.
   [Garcia-Garcia, Luis; Gomez-Oliver, Francisca; Angel Pozo, Miguel] Univ Complutense Madrid, Pluridisciplinary Inst, IdISSC, Madrid, Spain.
   [Garcia-Garcia, Luis; Gomez-Oliver, Francisca] Univ Complutense Madrid, Fac Pharm, Dept Pharmacol Pharmacognosy & Bot, Madrid, Spain.
   [Avila, Jesus] UAM, Ctr Mol Biol Severo Ochoa, CSIC, Madrid, Spain.
C3 Complutense University of Madrid; Complutense University of Madrid;
   Complutense University of Madrid; Complutense University of Madrid;
   Autonomous University of Madrid; Consejo Superior de Investigaciones
   Cientificas (CSIC); CSIC - Centro de Biologia Molecular Severo Ochoa
   (CBM)
RP Blázquez, E (corresponding author), Univ Complutense Madrid, Fac Med, Dept Biochem & Mol Biol, Madrid, Spain.
EM eblazquez@med.ucm.es
RI ; Pozo, Miguel A/L-1021-2014; Avila, Jesus/I-2610-2015; Pozo, Miguel
   A/L-1021-2014; Garcia-Garcia, Luis/L-1780-2014
OI Le Baut Ayuso, Yannick/0000-0001-7566-6753; Pozo, Miguel
   A/0000-0001-9303-0513; Avila, Jesus/0000-0002-6288-0571; Pozo, Miguel
   A/0000-0001-5934-1510; Garcia-Garcia, Luis/0000-0002-5704-5387
FU Ramon Areces Research Foundation [PR2007_18/01]; Spanish Ministerio de
   Ciencia e Innovacion [PID2019-106968RB-100]
FX This work was supported by the Ramon Areces Research Foundation,
   PR2007_18/01, and the Spanish Ministerio de Ciencia e Innovacion, Retos
   PID2019-106968RB-100.
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NR 222
TC 43
Z9 44
U1 0
U2 7
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD MAY 9
PY 2022
VL 13
AR 873301
DI 10.3389/fendo.2022.873301
PG 19
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 1L8QI
UT WOS:000799547000001
PM 35615716
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Li, CL
   Ma, SH
   Wu, CY
   Chang, PH
   Chang, YT
   Wu, CY
AF Li, C. -L.
   Ma, S. -H.
   Wu, C. -Y.
   Chang, P. -H.
   Chang, Y. -T.
   Wu, C. -Yi.
TI Association between sensorineural hearing loss and vitiligo: a
   nationwide population-based cohort study
SO JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
LA English
DT Article
ID LATE-ONSET VITILIGO; AUDIOLOGICAL ABNORMALITIES; METABOLIC SYNDROME;
   OXIDATIVE STRESS; MELANOCYTES; RISK; IMPAIRMENT; INCREASES; DISEASE
AB Background Vitiligo is an acquired depigmentation disease of the skin due to melanocyte destruction. A shared pathogenesis affecting melanocytes in the cochlea has been postulated. However, the association between vitiligo and sensorineural hearing loss (SNHL) is unclear. Objective To identify the association between vitiligo and SNHL. Methods This retrospective, nationwide cohort study included patients with vitiligo and age-, sex- and comorbidities-matched controls (propensity score matching; 1:4 ratio) from the National Health Insurance Research Database in Taiwan from 1 January 2000 to 31 December 2013. Results In total, 13 048 patients with vitiligo and 52 192 controls were included. SNHL developed in 0.61% patients with vitiligo and 0.29% controls. After adjusting for sex, age and comorbidities, a significant association between vitiligo and SNHL was found (adjusted hazard ratio, 2.18; 95% CI, 1.66-2.86). The other risk factors for developing SNHL included increased age, male sex, hyperlipidaemia, coronary artery disease and diffuse connective tissue diseases. In subgroup analysis, the association between vitiligo and SNHL remained significant in almost all the subgroups. Conclusion A 2.2-fold increased risk of developing SNHL was found in patients with vitiligo. Proper referral to otologists for early screening and closer follow-up of SNHL should be considered for patients with vitiligo, especially for patients with older age.
C1 [Li, C. -L.; Ma, S. -H.; Chang, Y. -T.; Wu, C. -Yi.] Taipei Vet Gen Hosp, Dept Dermatol, Taipei, Taiwan.
   [Li, C. -L.; Ma, S. -H.; Wu, C. -Y.; Chang, Y. -T.; Wu, C. -Yi.] Natl Yang Ming Chiao Tung Univ, Sch Med, Fac Med, Taipei, Taiwan.
   [Wu, C. -Y.; Chang, P. -H.] Natl Yang Ming Chiao Tung Univ, Inst Biomed Informat, Taipei, Taiwan.
   [Wu, C. -Y.] Natl Yang Ming Chiao Tung Univ, Inst Clin Med, Sch Med, Taipei, Taiwan.
   [Wu, C. -Y.; Wu, C. -Yi.] Natl Yang Ming Chiao Tung Univ, Inst Publ Hlth, Taipei, Taiwan.
   [Wu, C. -Y.; Wu, C. -Yi.] Natl Yang Ming Chiao Tung Univ, Dept Publ Hlth, Taipei, Taiwan.
   [Wu, C. -Y.] Taipei Vet Gen Hosp, Div Translat Res, Taipei, Taiwan.
   [Wu, C. -Y.] Taipei Vet Gen Hosp, Ctr Excellence Canc Res, Taipei, Taiwan.
   [Wu, C. -Y.] China Med Univ, Dept Publ Hlth, Taichung, Taiwan.
   [Chang, Y. -T.; Wu, C. -Yi.] Natl Yang Ming Chiao Tung Univ, Dept Dermatol, Taipei, Taiwan.
C3 Taipei Veterans General Hospital; National Yang Ming Chiao Tung
   University; National Yang Ming Chiao Tung University; National Yang Ming
   Chiao Tung University; National Yang Ming Chiao Tung University;
   National Yang Ming Chiao Tung University; Taipei Veterans General
   Hospital; Taipei Veterans General Hospital; China Medical University
   Taiwan; National Yang Ming Chiao Tung University
RP Wu, CY (corresponding author), Taipei Vet Gen Hosp, Dept Dermatol, Taipei, Taiwan.; Wu, CY (corresponding author), Natl Yang Ming Chiao Tung Univ, Sch Med, Fac Med, Taipei, Taiwan.; Wu, CY (corresponding author), Natl Yang Ming Chiao Tung Univ, Inst Publ Hlth, Taipei, Taiwan.; Wu, CY (corresponding author), Natl Yang Ming Chiao Tung Univ, Dept Publ Hlth, Taipei, Taiwan.; Wu, CY (corresponding author), Natl Yang Ming Chiao Tung Univ, Dept Dermatol, Taipei, Taiwan.
EM chenyiok@gmail.com
RI Ma, Sheng-Hsiang/ABB-1452-2021
OI MA, SHENG HSIANG/0000-0003-1160-5083; Li, Chia Lun/0000-0003-0243-7858
FU Taipei Veterans General Hospital, Taiwan [V110C-021]
FX This study was funded by grants from the Taipei Veterans General
   Hospital, Taiwan (V110C-021). The funding sources had no role in the
   design and conduct of the study; collection, management, analysis and
   interpretation of the data; preparation, review or approval of the
   manuscript and decision to submit the manuscript for publication.
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NR 46
TC 8
Z9 8
U1 4
U2 11
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0926-9959
EI 1468-3083
J9 J EUR ACAD DERMATOL
JI J. Eur. Acad. Dermatol. Venereol.
PD JUL
PY 2022
VL 36
IS 7
BP 1097
EP 1103
DI 10.1111/jdv.18047
EA MAR 2022
PG 7
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 2T8WM
UT WOS:000770556600001
PM 35274365
DA 2025-06-11
ER

PT J
AU Cheng, G
   Ma, TT
   Deng, ZH
   Gutiérrez-Gamboa, G
   Ge, Q
   Xu, PK
   Zhang, QW
   Zhang, JX
   Meng, JF
   Reiter, RJ
   Fang, YL
   Sun, XY
AF Cheng, Guo
   Ma, Tingting
   Deng, Zhihao
   Gutierrez-Gamboa, Gaston
   Ge, Qian
   Xu, Pingkang
   Zhang, Qianwen
   Zhang, Junxiang
   Meng, Jiangfei
   Reiter, Russel J.
   Fang, Yulin
   Sun, Xiangyu
TI Plant-derived melatonin from food: a gift of nature
SO FOOD & FUNCTION
LA English
DT Review
ID TOTAL ANTIOXIDANT CAPACITY; NEUTRAL PROTEINASE CALPAIN; GRAPE-RELATED
   FOODSTUFFS; URINARY 6-SULFATOXYMELATONIN; STRUCTURAL-CHARACTERIZATION;
   BIOLOGICAL FUNCTIONS; METABOLIC SYNDROME; N-ACETYLSEROTONIN; FUNCTIONAL
   ROLES; EDIBLE PLANTS
AB In recent years, people have become increasingly interested in bioactive ingredients from plants, especially antioxidant molecules such as melatonin, which are beneficial to human health. The purpose of this article is to provide new information on plant-derived foods with a high content of melatonin. We comprehensively summarize the content of melatonin in plant-derived foods and discuss the factors that influence melatonin levels to provide new ideas on enhancement. Additionally, we describe the biosynthetic pathway of melatonin and identify its major functions. Medicinal herbs are often rich in melatonin while many vegetables and fruits exhibit somewhat lower levels with wide variations among species. The genetic traits of plants, the phenological stage of the cultivar, the photoperiod, the level of stress to which the plants are exposed at the time of harvest, exposure to agrochemicals and determination methods are the main factors affecting the melatonin content. To date, standardization of uniform sampling times and the use of suitable pretreatments as well as determination methods have not been achieved. The results of the studies reviewed highlight the potentially important role of plant melatonin in influencing the progression of human diseases. Based on the health promotional aspects of melatonin, consuming foods containing higher concentrations of tryptophan and melatonin is suggested.
C1 [Cheng, Guo; Ma, Tingting; Deng, Zhihao; Ge, Qian; Meng, Jiangfei; Fang, Yulin; Sun, Xiangyu] Northwest A&F Univ, Coll Food Sci & Engn, Coll Enol, Yangling 712100, Shaanxi, Peoples R China.
   [Gutierrez-Gamboa, Gaston] Univ Talca, Fac Ciencias Agr, 2 Norte 685,Casilla 747, Talca 346000, Chile.
   [Ge, Qian] Ningxia Acad Agr Sci, Qual Stand & Testing Inst Agr Technol, Yinchuan 750002, Ningxia, Peoples R China.
   [Xu, Pingkang] Natl Univ Singapore, Coll Sci, Dept Chem Food Sci & Technol Programme, Singapore 119077, Singapore.
   [Zhang, Qianwen] Mississippi State Univ, Dept Plant & Soil Sci, Mississippi State, MS 39762 USA.
   [Zhang, Junxiang] Ningxia Univ, Sch Wine, Yinchuan 750021, Ningxia, Peoples R China.
   [Reiter, Russel J.] UT Hlth San Antonio, Dept Cell Syst & Anat, Joe R & Teresa Lozano Long Sch Med, San Antonio, TX 78229 USA.
C3 Northwest A&F University - China; Universidad de Talca; Ningxia Academy
   of Agricultural & Forestry Sciences; National University of Singapore;
   Mississippi State University; Ningxia University; University of Texas
   System; University of Texas Health Science Center at San Antonio
RP Fang, YL; Sun, XY (corresponding author), Northwest A&F Univ, Coll Food Sci & Engn, Coll Enol, Yangling 712100, Shaanxi, Peoples R China.; Reiter, RJ (corresponding author), UT Hlth San Antonio, Dept Cell Syst & Anat, Joe R & Teresa Lozano Long Sch Med, San Antonio, TX 78229 USA.
EM REITER@uthscsa.edu; fangyulin@nwsuaf.edu.cn; sunxiangyu@nwafu.edu.cn
RI Zhang, Qianwen/GLS-3399-2022; 郑, 崴/JVE-0040-2024; Meng,
   Jiangfei/G-6674-2011; Reiter, Russel/D-3221-2009
OI Zhang, Qianwen/0000-0002-1058-3348
FU National Nature Science Foundation [31901971]; China Postdoctoral
   Science Foundation [2020M673507]; Shaanxi Postdoctoral Science
   Foundation [2018BSHYDZZ77]; Natural Science Foundation of Ningxia
   [2018AAC03182]
FX This study was supported by the National Nature Science Foundation
   Project (31901971), the class General Financial Grant from the China
   Postdoctoral Science Foundation (2020M673507), the class General
   Financial Grant from the Shaanxi Postdoctoral Science Foundation
   (2018BSHYDZZ77), and the Natural Science Foundation of Ningxia
   (2018AAC03182).
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NR 145
TC 39
Z9 39
U1 3
U2 100
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PD APR 7
PY 2021
VL 12
IS 7
DI 10.1039/d0fo03213a
EA MAR 2021
PG 22
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA RM3XC
UT WOS:000635685000001
PM 33877242
DA 2025-06-11
ER

PT J
AU Dodd, JD
   Leipsic, J
AF Dodd, Jonathan D.
   Leipsic, Jonathon
TI Cardiovascular CT and MRI in 2019: Review of Key Articles
SO RADIOLOGY
LA English
DT Review
ID HYPERTROPHIC CARDIOMYOPATHY; ANGIOGRAPHY
AB Cardiac imaging is becoming commonplace throughout radiology practices and is increasingly important in large-cohort prospective cardiovascular trials and in statements and guidelines. In this review, the authors summarize some of the most important imaging findings relevant to clinical practice in the past year. Key coronary CT angiography studies have included rigorous meta-analysis of its diagnostic accuracy, prognostic implications of adverse coronary plaque features, and sex differences. The value of CT for catheter-delivered valve implantation (eg, transcatheter aortic and mitral valve replacements) was further elucidated in large-cohort outcome trials. Hypertrophic cardiomyopathy registries have revealed distinct clinical and MRI phenotypes, highlighting different underlying causes, while others clarified the prognostic usefulness of MRI in hypertrophic cardiomyopathy and Fabry disease. Artificial intelligence and/or machine learning was applied to many aspects of cardiovascular imaging, while evidence of the benefits of both adenosine stress perfusion cardiac MRI and coronary CT angiography-derived fractional flow reserve from real-world trials has increased. Studies on vaping and vascular endothelial function and the whole-body MRI depiction of metabolic syndrome consequences were also noteworthy. Although this review focuses on Radiology articles, key articles from high-impact clinical journals are also included. Although not possible to detail all articles because of space limitations, the authors attempted to highlight those with the most pragmatic and scientific value. (C) RSNA, 2020
C1 [Dodd, Jonathan D.] St Vincents Univ Hosp, Dept Radiol, Elm Pk, Dublin D4, Ireland.
   [Dodd, Jonathan D.] Univ Coll Dublin, Sch Med, Dublin, Ireland.
   [Leipsic, Jonathon] Univ British Columbia, Dept Radiol, St Pauls Hosp, Vancouver, BC, Canada.
C3 University College Dublin; Saint Vincent's University Hospital;
   University College Dublin; University of British Columbia; St. Paul's
   Hospital
RP Dodd, JD (corresponding author), St Vincents Univ Hosp, Dept Radiol, Elm Pk, Dublin D4, Ireland.; Dodd, JD (corresponding author), Univ Coll Dublin, Sch Med, Dublin, Ireland.
EM jdodd@svhg.ie
RI Leipsic, Jonathon/ABE-6194-2020
OI Dodd, Jonathan/0000-0002-3476-8793
CR Andreini D, 2019, CIRC-CARDIOVASC INTE, V12, DOI 10.1161/CIRCINTERVENTIONS.118.007607
   [Anonymous], 2019, RADIOLOGY, V293, P97
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NR 35
TC 6
Z9 6
U1 2
U2 16
PU RADIOLOGICAL SOC NORTH AMERICA (RSNA)
PI OAK BROOK
PA 820 JORIE BLVD, SUITE 200, OAK BROOK, ILLINOIS, UNITED STATES
SN 0033-8419
J9 RADIOLOGY
JI Radiology
PD OCT
PY 2020
VL 297
IS 1
BP 17
EP 30
DI 10.1148/radiol.2020200605
PG 14
WC Radiology, Nuclear Medicine & Medical Imaging
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Radiology, Nuclear Medicine & Medical Imaging
GA NV3YZ
UT WOS:000574262800017
PM 32749209
DA 2025-06-11
ER

PT J
AU Magenis, ML
   Damiani, AP
   de Marcos, PS
   de Pieri, E
   de Souza, E
   Vilela, TC
   de Andrade, VM
AF Magenis, Marina Lummertz
   Damiani, Adriani Paganini
   de Marcos, Pamela Souza
   de Pieri, Ellen
   de Souza, Emanuel
   Vilela, Thais Cereser
   de Andrade, Vanessa Moraes
TI Fructose consumption during pregnancy and lactation causes DNA damage
   and biochemical changes in female mice
SO MUTAGENESIS
LA English
DT Article
ID OXIDATIVE STRESS; METABOLIC SYNDROME; MONOSODIUM GLUTAMATE; MICRONUCLEUS
   ASSAY; BONE-MARROW; COMET ASSAY; GLUCOSE; GESTATION; LIVER; DIET
AB The consumption of fructose during pregnancy can cause hyperglycaemia and may stimulate production of reactive oxygen species; however, there are only a few studies reporting whether fructose consumption during pregnancy causes DNA damage.Therefore, the aim of this study was to evaluate the effects of fructose consumption on genetic and biochemical parameters in Swiss mice treated during pregnancy and lactation. For this, 15 couples of 60-day-old Swiss mice were divided into three groups of five couples: negative control (water) and two fructose groups (fructose dose of 10%/l and 20%/l). During this period, we evaluated food consumption, energy efficiency and body weight. Samples of blood were collected from the females before copulation, after the 15th day of conception and on the 21st day after the lactation period, for the glycaemic and lipid profiles as well as comet assay and micronucleus (MN) test. Comet assay and MN test evaluate DNA damage and clastogenicity, respectively. In the gestation and lactation period, the two fructose doses tested showed DNA damage as observed in the comet assay, which is associated with an increase in dietary intake, body weight, lipid profile and fasting glycaemia in females. Thus, it can be suggested that the high consumption of fructose during these periods is harmful for pregnancy and lactation.
C1 [Magenis, Marina Lummertz; Damiani, Adriani Paganini; de Marcos, Pamela Souza; Vilela, Thais Cereser; de Andrade, Vanessa Moraes] Univ Southern Santa Catarina, UNESC, Dept Hlth Sci, Lab Translat Biomed, 1105 Univ Rd, BR-88806000 Criciuma, SC, Brazil.
   [de Pieri, Ellen] Univ Southern Santa Catarina, UNESC, Dept Hlth Sci, Lab Translat Pathophysiol, 1105 Univ Rd, BR-88806000 Criciuma, SC, Brazil.
   [de Souza, Emanuel] Univ Southern Santa Catarina, UNESC, Dept Hlth Sci, Course Biomed,Grad Program Hlth Sci, 1105 Univ Rd, BR-88806000 Criciuma, SC, Brazil.
C3 Universidade do Sul de Santa Catarina; Universidade do Sul de Santa
   Catarina; Universidade do Sul de Santa Catarina
RP de Andrade, VM (corresponding author), Univ Southern Santa Catarina, UNESC, Dept Hlth Sci, Lab Translat Biomed, 1105 Univ Rd, BR-88806000 Criciuma, SC, Brazil.
EM vmoraesdeandrade@yahoo.com.br
RI de Souza, Emanuel/H-5938-2013; Andrade, Vanessa/F-9623-2012; Damiani,
   Adriani/N-8007-2018; De Pieri, Ellen/LLM-3032-2024
OI Vilela, Thais Cereser/0000-0002-2986-1715; De Pieri,
   Ellen/0000-0002-2449-1225
FU Graduate Program in Health Sciences (PPGCS); Coordination for the
   Improvement of Higher Education Personnel (CAPES); National Council of
   Technological and Scientific Development (CNPq); CNPq [304203/2018-1];
   Santa Catarina State Research and Innovation Support Foundation
   (FAPESC); University of Southern Santa Catarina (UNESC)
FX The authors would also like to thank the Graduate Program in Health
   Sciences (PPGCS), Coordination for the Improvement of Higher Education
   Personnel (CAPES), National Council of Technological and Scientific
   Development (CNPq), CNPq scholarship holder-Brazil (304203/2018-1),
   Santa Catarina State Research and Innovation Support Foundation (FAPESC)
   and University of Southern Santa Catarina (UNESC) for fellowship
   support.
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NR 57
TC 7
Z9 7
U1 0
U2 7
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0267-8357
EI 1464-3804
J9 MUTAGENESIS
JI Mutagenesis
PD MAR
PY 2020
VL 35
IS 2
BP 179
EP 187
DI 10.1093/mutage/geaa001
PG 9
WC Genetics & Heredity; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Genetics & Heredity; Toxicology
GA LS6PZ
UT WOS:000536504800004
PM 31967303
DA 2025-06-11
ER

PT J
AU Puhl, RM
   Himmelstein, MS
   Pearl, RL
AF Puhl, Rebecca M.
   Himmelstein, Mary S.
   Pearl, Rebecca L.
TI Weight Stigma as a Psychosocial Contributor to Obesity
SO AMERICAN PSYCHOLOGIST
LA English
DT Article
DE stigma; obesity; weight; weight loss
ID QUALITY-OF-LIFE; DISORDERED EATING BEHAVIORS; PERCEIVED WEIGHT; BODY
   DISSATISFACTION; BIAS INTERNALIZATION; LOSS SURGERY; GENDER
   DISCRIMINATION; SEEKING INDIVIDUALS; METABOLIC SYNDROME;
   PHYSICAL-ACTIVITY
AB Weight stigma is a key aspect of the lived experience of individuals with obesity, and adversely affects health. This article provides an overview of recent evidence examining links between experiences of weight stigma and weight-related behaviors and health (e.g., maladaptive eating, physical activity, stress, obesity, weight loss), including health consequences for individuals with heightened vulnerability to weight stigma (e.g., youth and people seeking bariatric surgery) and implications for clinicians working with individuals who have obesity. This literature points to weight stigma as a psychosocial contributor to obesogenic behaviors, yet the role of weight stigma in weight loss among treatment-seeking individuals has received little attention. Research priorities are identified, including the need for future studies to (a) determine the potentially predictive value of specific characteristics of weight-stigmatizing experiences for weight loss (such as the time period, interpersonal sources, and coping responses for stigma experiences), (b) identify mechanisms through which weight stigma may undermine or facilitate weight-related treatment outcomes, and (c) test strategies that can be implemented in weight management programs to reduce the negative impact of weight stigma on health behaviors. Broadly, more attention should be directed to weight stigma in the obesity field as a relevant psychosocial factor in obesity-focused prevention and treatment.
C1 [Puhl, Rebecca M.] Univ Connecticut, Dept Human Dev & Family Sci, Hartford, CT 06103 USA.
   [Puhl, Rebecca M.] Univ Connecticut, Rudd Ctr Food Policy & Obes, 1 Constitut Plaza,Suite 600, Hartford, CT 06103 USA.
   [Himmelstein, Mary S.] Kennesaw State Univ, Dept Psychol Sci, Kennesaw, GA 30144 USA.
   [Pearl, Rebecca L.] Univ Penn, Ctr Weight & Eating Disorders, Dept Psychiat, Perelman Sch Med, Philadelphia, PA 19104 USA.
C3 University of Connecticut; University of Connecticut; University System
   of Georgia; Kennesaw State University; University of Pennsylvania
RP Puhl, RM (corresponding author), Univ Connecticut, Rudd Ctr Food Policy & Obes, 1 Constitut Plaza,Suite 600, Hartford, CT 06103 USA.
EM rebecca.puhl@uconn.edu
RI Pearl, Rebecca/GRS-0019-2022; Puhl, Rebecca/ABE-9260-2021
OI Himmelstein, Mary/0000-0002-3173-1901
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   ,, 1992, American Journal of Clinical Nutrition, V55, p615S
NR 159
TC 294
Z9 334
U1 17
U2 160
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 0003-066X
EI 1935-990X
J9 AM PSYCHOL
JI Am. Psychol.
PD FEB-MAR
PY 2020
VL 75
IS 2
SI SI
BP 274
EP 289
DI 10.1037/amp0000538
PG 16
WC Psychology, Multidisciplinary
WE Social Science Citation Index (SSCI)
SC Psychology
GA KP9BJ
UT WOS:000516523000012
PM 32053000
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Cowan, SF
   Leeming, ER
   Sinclair, A
   Dordevic, AL
   Truby, H
   Gibson, SJ
AF Cowan, Stephanie F.
   Leeming, Emily R.
   Sinclair, Andrew
   Dordevic, Aimee L.
   Truby, Helen
   Gibson, Simone J.
TI Effect of whole foods and dietary patterns on markers of subclinical
   inflammation in weight-stable overweight and obese adults: a systematic
   review
SO NUTRITION REVIEWS
LA English
DT Review
ID C-REACTIVE PROTEIN; DISEASE RISK-FACTORS; CARDIOVASCULAR-DISEASE;
   ENDOTHELIAL FUNCTION; METABOLIC SYNDROME; OXIDATIVE STRESS;
   POSTMENOPAUSAL WOMEN; ADHESION MOLECULES; BODY-COMPOSITION;
   ADIPOSE-TISSUE
AB Context: Reduction of subclinical inflammation is a potential target for chronic disease management. Adiposity is a known modifier of meta-inflammation; however, the influence of dietary factors is less clear. Objective: This review examines evidence from human trials evaluating effects of whole foods or dietary patterns on circulating inflammatory markers in weight-stable overweight and obese adults. It is the first review to investigate effects of diet on inflammation, independent of changes in adiposity. Data Sources: The Ovid MEDLINE, EMBASE, CINAHL, and Cochrane databases were searched. Data Extraction: Data extraction was conducted using the Cochrane Collaboration Handbook for Systematic Reviews of Interventions. Data Analysis: Study quality was evaluated using the Cochrane Collaboration Risk of Bias Assessment tool. Thirty-three studies were included assessing effects of 17 foods and dietary patterns on 39 inflammatory markers. Conclusions: Overall, foods and dietary patterns were not found to have significant effects on inflammatory markers in weight-stable individuals. Inconsistencies among studies were largely due to methodological limitations. Future research should invest in longer intervention periods and standardization of inflammatory marker panels paired with novel technologies, while ensuring anthropometric measures are monitored and adequately controls are used.
C1 [Cowan, Stephanie F.; Leeming, Emily R.; Sinclair, Andrew; Dordevic, Aimee L.; Truby, Helen; Gibson, Simone J.] Monash Univ, Dept Nutr Dietet & Food, Be Act Sleep & Eat Facil Level 1, Melbourne, Vic 3168, Australia.
C3 Monash University
RP Gibson, SJ (corresponding author), Monash Univ, Dept Nutr Dietet & Food, Be Act Sleep & Eat Facil Level 1, Melbourne, Vic 3168, Australia.
EM simone.gibson@monash.edu
RI Truby, Helen/ABF-5095-2020; Dordevic, Aimee/AFI-3088-2022
OI Truby, Helen/0000-0002-1992-1649; Dordevic, Aimee/0000-0002-0405-3164;
   Cowan, Stephanie/0000-0001-6731-4221
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NR 83
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Z9 16
U1 0
U2 3
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0029-6643
EI 1753-4887
J9 NUTR REV
JI Nutr. Rev.
PD JAN
PY 2020
VL 78
IS 1
BP 19
EP 38
DI 10.1093/nutrit/nuz030
PG 20
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA NN8YG
UT WOS:000569073000002
PM 31429908
DA 2025-06-11
ER

PT J
AU Kim, Y
   Park, CW
AF Kim, Yaeni
   Park, Cheol Whee
TI Mechanisms of Adiponectin Action: Implication of Adiponectin Receptor
   Agonism in Diabetic Kidney Disease
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE adiponectin; metabolism; AdipoRon; lipotoxicity
ID MOLECULE ADIPOR AGONIST; II TYPE-1 RECEPTOR; PLASMA ADIPONECTIN; SHORT
   LIFE; AMPK; ALBUMINURIA; LIPOTOXICITY; EXPRESSION; EXCRETION; CERAMIDE
AB Adiponectin, an adipokine secreted by adipocytes, exerts favorable effects in the milieu of diabetes and metabolic syndrome through its anti-inflammatory, antifibrotic, and antioxidant effects. It mediates fatty acid metabolism by inducing AMP-activated protein kinase (AMPK) phosphorylation and increasing peroxisome proliferative-activated receptor (PPAR)- expression through adiponectin receptor (AdipoR)1 and AdipoR2, respectively, which in turn activate PPAR gamma coactivator 1 alpha (PGC-1), increase the phosphorylation of acyl CoA oxidase, and upregulate the uncoupling proteins involved in energy consumption. Moreover, adiponectin potently stimulates ceramidase activity associated with its two receptors and enhances ceramide catabolism and the formation of its anti-apoptotic metabolite, sphingosine 1 phosphate (S1P), independently of AMPK. Low circulating adiponectin levels in obese patients with a risk of insulin resistance, type 2 diabetes, and cardiovascular diseases, and increased adiponectin expression in the state of albuminuria suggest a protective and compensatory role for adiponectin in mitigating further renal injury during the development of overt diabetic kidney disease (DKD). We propose AdipoRon, an orally active synthetic adiponectin receptor agonist as a promising drug for restoration of DKD without inducing systemic adverse effects. Its renoprotective role against lipotoxicity and oxidative stress by enhancing the AMPK/PPAR pathway and ceramidase activity through AdipoRs is revealed here.
C1 [Kim, Yaeni; Park, Cheol Whee] Catholic Univ Korea, Coll Med, Dept Internal Med, Div Nephrol, 222 Banpo Daero, Seoul 06591, South Korea.
   [Park, Cheol Whee] Catholic Univ Korea, Coll Med, Inst Aging & Metab Dis, Seoul 06591, South Korea.
C3 Catholic University of Korea; Catholic University of Korea
RP Park, CW (corresponding author), Catholic Univ Korea, Coll Med, Dept Internal Med, Div Nephrol, 222 Banpo Daero, Seoul 06591, South Korea.; Park, CW (corresponding author), Catholic Univ Korea, Coll Med, Inst Aging & Metab Dis, Seoul 06591, South Korea.
EM yaenikim82@gmail.com; cheolwhee@hanmail.net
FU Basic Science Research Program through the National Research Foundation
   of Korea (NRF) - Ministry of Education, Science and Technology
   [2016R1A2B2015980]
FX This study was supported by grants from the Basic Science Research
   Program through the National Research Foundation of Korea (NRF) funded
   by the Ministry of Education, Science and Technology (CWP:
   2016R1A2B2015980).
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NR 70
TC 80
Z9 88
U1 3
U2 31
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD APR
PY 2019
VL 20
IS 7
AR 1782
DI 10.3390/ijms20071782
PG 12
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA HU4PM
UT WOS:000465258100087
PM 30974901
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Tong, J
   Guo, JJ
AF Tong, J.
   Guo, J-J
TI Key molecular pathways in the progression of non-alcoholic
   steatohepatitis
SO EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
LA English
DT Article
DE Non-alcoholic steatohepatitis; NOD-like receptors; Mitochondria
ID FATTY LIVER-DISEASE; NLRP3 INFLAMMASOME; ACTIVATION; FIBROSIS; MICE;
   MACROPHAGES; PREVALENCE; PYROPTOSIS; REGULATOR; PROTECTS
AB Nonalcoholic fatty liver disease (NAFLD) has become the most common chronic liver disease worldwide and also become an emerging risk factor for liver-related complications, such as cirrhosis and hepatocellular carcinoma (HCC). The liver-related burden of NASH is likely to increase and nonalcoholic steatohepatitis (NASH) is probably to be the leading indication for liver transplantation by 2020, as a consequence of increased disease prevalence and of the lack of an effective treatment. The first step in the NAFLD development is represented by fat accumulation in the liver, a condition that is commonly associated with features of the metabolic syndrome. Notably, it has been acknowledged that the step from nonalcoholic fatty liver (NA-FL) to NASH is key step in the NASH formation, and the mechanisms behind this transition have been extensively studied. Emerging evidence indicates that innate immunity is a driving force in NAFLD progression because it directly regulates all key pathogenic features of the disease processes, including metabolic dysregulation, inflammation, and fibrosis. In this review, we summarize the currently available signaling pathways of NASH formation, including oxidative stress, NOD-like receptors (NLRB), mitochondria-associated pathways, Toll-like receptors (TLRs), nuclear receptors, and other signal pathways, for the aim of a better understanding of this disease.
C1 [Tong, J.; Guo, J-J] Chongqing Univ, Cent Hosp, Chongqing Emergency Med Ctr, Dept Gastroenterol & Hepatol, Chongqing, Peoples R China.
C3 Chongqing University
RP Tong, J (corresponding author), Chongqing Univ, Cent Hosp, Chongqing Emergency Med Ctr, Dept Gastroenterol & Hepatol, Chongqing, Peoples R China.
EM guojinjun1972@163.com
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NR 65
TC 21
Z9 21
U1 0
U2 14
PU VERDUCI PUBLISHER
PI ROME
PA VIA GREGORIO VII, ROME, 186-00165, ITALY
SN 1128-3602
J9 EUR REV MED PHARMACO
JI Eur. Rev. Med. Pharmacol. Sci.
PY 2019
VL 23
IS 19
BP 8515
EP 8522
DI 10.26355/eurrev_201910_19165
PG 8
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA JH3RG
UT WOS:000492684500038
PM 31646583
DA 2025-06-11
ER

PT J
AU Ebrahimzadeh, V
   Ardalan, MR
   Mandavi, AM
   Gorbani, A
AF Ebrahimzadeh, Vabideh
   Ardalan, Mohammad Reza
   Mandavi, Aida Malek
   Gorbani, Abolfazl
TI A review of the health hazards of artificial sweeteners: are they safe?
SO PROGRESS IN NUTRITION
LA English
DT Review
DE artificial sweeteners; non-nutritive sweeteners; side effect; adverse
   effect; obesity; metabolic; nephrotoxic; gut microbiome
ID HIGH-INTENSITY SWEETENERS; INDUCED OXIDATIVE STRESS; LOW-CALORIE
   SWEETENERS; DIET SODA INTAKE; NONNUTRITIVE SWEETENERS; METABOLIC
   SYNDROME; GUT MICROBIOME; GLP-1 RELEASE; ACESULFAME-K; ASPARTAME
AB The increasing prevalence of obesity and diabetes mellitus has led to an increased production and consumption of artificially sweetened foods all over the world. Artificial sweeteners are high-intensity sweeteners which contribute no calorie. As a result, most of these foods may be sold with a "healthy" or "diet" labeling; however, there have been lots of controversy regarding their safety and adverse health effects. Therefore, the present article review aimed to summarize the results of most relevant studies concerning side effects of artificial sweeteners. Accordingly, a search of several databases was performed to identify all related manuscripts from 1980 to 2016. As a result, most of the available animal studies demonstrated that chronic exposure to artificial sweeteners led to increased body weight, impairment of glucose and insulin homeostasis, alteration in gut microbiota, neurobehavioral effects and also induction of kidney injury and cancer. However, the existing clinical and epidemiologic data are partly inconsistent to make a definitive conclusion regarding some of those adverse effects. In conclusion, consumers should be aware of the potential side effects of artificial sweeteners and it may be recommended that only minimal amounts of NNS could be consumed.
C1 [Ebrahimzadeh, Vabideh] Maraghe Univ Med Sci, Maraghe, Iran.
   [Ardalan, Mohammad Reza] Tabriz Univ Med Sci, Kidney Res Ctr, Tabriz, Iran.
   [Mandavi, Aida Malek] Tabriz Univ Med Sci, Connect Tissue Dis Res Ctr, Tabriz, Iran.
   [Gorbani, Abolfazl] Islamic Azad Univ, Shabestar Branch, Dept Anim Sci, Shabestar, Iran.
C3 Tabriz University of Medical Science; Tabriz University of Medical
   Science; Islamic Azad University
RP Ebrahimzadeh, V (corresponding author), Maragheh Univ Med Sci, Nutr, Maragheh, Iran.
EM ebrahimzadeh.va@gmail.com
RI Mahdavi, Aida/N-3109-2017; ardalan, mohammadreza/AAM-1367-2020; Attari,
   Vahideh/N-2172-2017; gorbani, abolfazl/AAT-5809-2021
OI Ardalan, Mohammadreza/0000-0002-6851-5460
FU Kidney Research Center, Tabriz University of Medical Sciences (Tabriz,
   Iran)
FX This study was supported by Kidney Research Center, Tabriz University of
   Medical Sciences (Tabriz, Iran). The authors have declared that there is
   no conflict of interest.
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NR 98
TC 8
Z9 8
U1 12
U2 144
PU MATTIOLI 1885
PI FIDENZA
PA VIA DELLA LODESANA 649-SX, FIDENZA, 43046 PR, ITALY
SN 1129-8723
J9 PROG NUTR
JI Prog. Nutr.
PD DEC
PY 2018
VL 20
SU 2
BP 36
EP 43
DI 10.23751/pn.v20i2-S.5901
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA HY0RW
UT WOS:000467821100003
DA 2025-06-11
ER

PT J
AU Scolaro, B
   Kim, HSJ
   de Castro, IA
AF Scolaro, Bianca
   Kim, Hellen Soo Jin
   de Castro, Inar Alves
TI Bioactive compounds as an alternative for drug co-therapy: Overcoming
   challenges in cardiovascular disease prevention
SO CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
LA English
DT Review
DE Atherosclerosis; statin; omega 3; plant sterol; phenolic compounds
ID N-3 FATTY-ACIDS; DENSITY-LIPOPROTEIN CHOLESTEROL; PLANT STEROLS;
   LDL-CHOLESTEROL; GREEN TEA; EICOSAPENTAENOIC ACID; DOUBLE-BLIND;
   FISH-OIL; ATHEROSCLEROTIC PLAQUES; METABOLIC SYNDROME
AB Different pharmacological interventions have been applied with success to reduce the progression of atherosclerosis. However, many patients are not good responders or must interrupt treatment due to adverse effects. Bioactive compounds such as omega-3 fatty acids (n-3 FA), plant sterol esters (PSE) and phenolic compounds (PHC) are natural molecules with great potential to reduce the atherosclerosis burden by reducing inflammation, LDL cholesterol (LDL-C) and oxidative stress, respectively. Although their physiological effects on biomarkers are much lower than those expected by drugs used for the same purpose, bioactive compounds can easily be incorporated into the daily diet and present no adverse effects. However, little is known about the combination of n-3 FA, PSE, PHC, and drugs in atherosclerosis progression. This review article summarizes potential effects of co-therapies involving n-3 FA, PSE, and PHC combined with major hypolipidemic drugs on atherosclerosis biomarkers and clinical outcomes. Evidence of additive and/or complementary effects regarding drugs action reveals possible roles for bioactive compounds in disease management. Pharmaceutical companies, physicians, and food scientists should be prepared to better understand this type of interaction and its consequences in terms of efficacy and life quality.
C1 [Scolaro, Bianca; Kim, Hellen Soo Jin; de Castro, Inar Alves] Univ Sao Paulo, Fac Pharmaceut Sci, Dept Food & Expt Nutr, Av Lineu Prestes 580,B14, BR-05508900 Sao Paulo, SP, Brazil.
C3 Universidade de Sao Paulo
RP de Castro, IA (corresponding author), Univ Sao Paulo, Fac Pharmaceut Sci, Dept Food & Expt Nutr, Av Lineu Prestes 580,B14, BR-05508900 Sao Paulo, SP, Brazil.
EM inar@usp.br
RI Castro, Inar/C-4923-2012; Scolaro, Bianca/C-9973-2014
OI Scolaro, Bianca/0000-0001-6436-8435; Poklar Ulrih,
   Natasa/0000-0002-2731-9973
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NR 135
TC 23
Z9 24
U1 0
U2 11
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1040-8398
EI 1549-7852
J9 CRIT REV FOOD SCI
JI Crit. Rev. Food Sci. Nutr.
PY 2018
VL 58
IS 6
BP 958
EP 971
DI 10.1080/10408398.2016.1235546
PG 14
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA FZ9OB
UT WOS:000427940200007
PM 27830947
DA 2025-06-11
ER

PT J
AU Zhang, K
   Dong, RX
   Sun, K
   Wang, XX
   Wang, JJ
   Yang, CS
   Zhang, JS
AF Zhang, Ke
   Dong, Ruixia
   Sun, Kang
   Wang, Xiaoxiao
   Wang, Jiajia
   Yang, Chung S.
   Zhang, Jinsong
TI Synergistic toxicity of epigallocatechin-3-gallate and
   diethyldithiocarbamate, a lethal encounter involving redox-active copper
SO FREE RADICAL BIOLOGY AND MEDICINE
LA English
DT Article
DE Catechins; Dithiocarbamates; Copper; Hepatotoxicity
ID GREEN TEA POLYPHENOL; FATTY LIVER-DISEASE; INDUCED DOPAMINERGIC
   NEUROTOXICITY; KAPPA-B ACTIVATION; HUMAN CANCER-CELLS;
   PYRROLIDINE-DITHIOCARBAMATE; SUPEROXIDE-DISMUTASE; METABOLIC SYNDROME;
   CELLULAR-DNA; DIETARY POLYPHENOLS
AB Dithiocarbamates (DTC) are widely used in agricultural, industrial and therapeutic domains. There are ample opportunities for human exposure to DTC. Green tea extracts, with epigallocatechin-3-gallate (EGCG) being the most abundant constituent, have been used as dietary supplements for body weight reduction. Our hypothesis is that DTC can act as a copper ionophore to increase hepatic levels of redox-active copper which promotes EGCG auto-oxidation to produce oxidative stress and toxicity. The results of the present study in a mouse model is consistent with this hypothesis, showing that co-administration of EGCG and diethyldithiocarbamate - a metabolite of disulfiram (a drug for alcohol aversion therapy), both at tolerable levels, caused lethality. The liver was the major organ site of toxicity. The co-administration drastically increased lipid peroxidation, DNA damage and cell apoptosis as well as caused deleterious transcriptional responses including basal and Nrf2 antioxidant systems in the liver. The results suggest that exposure to DTC reduces toxic threshold of dietary polyphenols from green tea and possibly other plants, and vice versa. This novel hypothesis is important to human health, and the dose-response relationship of this synergistic toxicity needs to be further characterized.
C1 [Zhang, Ke; Dong, Ruixia; Sun, Kang; Wang, Xiaoxiao; Wang, Jiajia; Zhang, Jinsong] Anhui Agr Univ, Sch Tea & Food Sci, State Key Lab Tea Plant Biol & Utilizat, 130 West Changjiang Rd, Hefei 230036, Anhui, Peoples R China.
   [Yang, Chung S.] Rutgers State Univ, Ernest Mario Sch Pharm, Dept Biol Chem, Piscataway, NJ USA.
   [Yang, Chung S.; Zhang, Jinsong] Anhui Agr Univ, Int Joint Res Lab Tea Chem & Hlth Effects, Hefei, Anhui, Peoples R China.
C3 Anhui Agricultural University; Rutgers University System; Rutgers
   University New Brunswick; Anhui Agricultural University
RP Zhang, JS (corresponding author), Anhui Agr Univ, Sch Tea & Food Sci, State Key Lab Tea Plant Biol & Utilizat, 130 West Changjiang Rd, Hefei 230036, Anhui, Peoples R China.
EM zjs@ahau.edu.cn
RI Wang, Jiajia/HCI-5717-2022; Zhang, Jinsong/Q-8032-2019; Zhang,
   Ke/ADP-4363-2022
OI Zhang, Jinsong/0000-0001-9366-9819; Zhang, Ke/0000-0002-4562-5405; Sun,
   Kang/0000-0002-1417-1914
FU National Natural Science Foundation of China [31771971, 31170648]
FX This work was supported by National Natural Science Foundation of China
   (31771971 and 31170648). We thank Guangshan Zhao for the performing on
   animal experiment in Fig. 1a, and Pingping Chen on animal experiment in
   Fig. 6a, b.
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NR 77
TC 28
Z9 28
U1 1
U2 35
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0891-5849
EI 1873-4596
J9 FREE RADICAL BIO MED
JI Free Radic. Biol. Med.
PD DEC
PY 2017
VL 113
BP 143
EP 156
DI 10.1016/j.freeradbiomed.2017.09.027
PG 14
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA FN2FP
UT WOS:000415806800013
PM 28974447
DA 2025-06-11
ER

PT J
AU Herieka, M
   Erridge, C
AF Herieka, Mohammed
   Erridge, Clett
TI High-fat meal induced postprandial inflammation
SO MOLECULAR NUTRITION & FOOD RESEARCH
LA English
DT Review
DE Endotoxin; High-fat meal; Postprandial inflammation; Toll-like receptor
ID C-REACTIVE PROTEIN; LOW-DOSE ENDOTOXEMIA; FACTOR-KAPPA-B; OXIDATIVE
   STRESS; ENDOTHELIAL FUNCTION; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   DIETARY PATTERNS; INNATE IMMUNITY; TNF-ALPHA
AB Raised levels of circulating inflammatory markers are associated with coronary artery disease, obesity and type II diabetes. It has been proposed that the ingestion of high-fat meals may serve as a stimulus to raise systemic inflammatory tone, although interventional studies have yielded conflicting results. We here review 57 studies of high-fat meal induced acute postprandial inflammation to identify the most frequently reported markers of postprandial inflammation and to compare these results with the highly consistent low-grade endotoxaemia model in man. Most plasma borne markers of inflammation, such as cytokines and soluble adhesion molecules, were not consistently raised after a high-fat meal. However, pro-inflammatory leukocyte surface markers, mRNA and proteins were elevated in almost all studies in which they were measured. These markers followed kinetics similar to those observed following intravenous injection of low doses of endotoxin in man, were positively associated with likelihood of contamination of test meals with pro-inflammatory bacterial molecules and were reduced in several studies examining parallel meals supplemented with foodstuffs containing anti-inflammatory phytochemicals. Future studies of postprandial inflammation may yield more consistent evidence by focusing on leukocyte, rather than plasma-borne, markers of inflammation and by considering the test meal content of pro- and anti-inflammatory dietary constituents.
C1 [Herieka, Mohammed; Erridge, Clett] Univ Leicester, Glenfield Hosp, Dept Cardiovasc Sci, NIHR Leicester Cardiovasc Biomed Res Unit, Leicester LE3 9QP, Leics, England.
C3 University Hospitals of Leicester NHS Trust; University of Leicester;
   Glenfield Hospital
RP Erridge, C (corresponding author), Univ Leicester, Glenfield Hosp, Dept Cardiovasc Sci, Leicester LE3 9QP, Leics, England.
EM ce55@le.ac.uk
OI Erridge, Clett/0000-0003-2978-346X
FU University of Leicester Department of Cardiovascular Sciences research
   fellowship
FX These studies were supported by a University of Leicester Department of
   Cardiovascular Sciences research fellowship awarded to C.E.
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NR 85
TC 166
Z9 187
U1 0
U2 46
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1613-4125
EI 1613-4133
J9 MOL NUTR FOOD RES
JI Mol. Nutr. Food Res.
PD JAN
PY 2014
VL 58
IS 1
BP 136
EP 146
DI 10.1002/mnfr.201300104
PG 11
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA 302GI
UT WOS:000330590100012
PM 23847095
OA Bronze
DA 2025-06-11
ER

PT J
AU Ferré, R
   Aragonès, G
   Plana, N
   Merino, J
   Heras, M
   Buixadera, C
   Masana, L
AF Ferre, Raimon
   Aragones, Gemma
   Plana, Nuria
   Merino, Jordi
   Heras, Merche
   Buixadera, Carme
   Masana, Luis
TI High-density lipoprotein cholesterol and apolipoprotein A1 levels
   strongly influence the reactivity of small peripheral arteries
SO ATHEROSCLEROSIS
LA English
DT Article
DE HDL; Apolipoprotein A1; Smoking; Peripheral artery tonometry; Reactive
   hyperaemia
ID CORONARY-HEART-DISEASE; ENDOTHELIAL DYSFUNCTION; CARDIOVASCULAR-DISEASE;
   NITRIC-OXIDE; AMPLITUDE; ATHEROSCLEROSIS; TONOMETRY; SMOKING; CELLS; HDL
AB Objective: Reactive hyperaemia after shear stress is a surrogate marker of endothelial function. However, the mechanisms controlling the dilation capacity of small peripheral resistance arteries are not well characterised. We evaluated reactive hyperaemia by peripheral artery tonometry (PAT) in the acral arteries and studied their clinical and biochemical determinants.
   Methods: Eight hundred sixteen subjects at intermediate to high cardiovascular risk were recruited. The reactive hyperaemia index (RHI) of small digital arteries was measured by PAT. Clinical history data, anthropometry and biochemical parameters were also analysed. We studied the associations between clinical and biochemical factors and small artery RHI.
   Results: HDL cholesterol and apolipoprotein A1 levels were strongly and directly correlated with an increased dilation response. Metabolic syndrome components, such as increased waist circumference, hypertriglyceridaemia and smoking, were inversely associated with RHI as were serum markers of inflammation. The predictors of small peripheral artery RHI were HDL cholesterol, which had a protective effect, and smoking, which had a negative impact.
   Conclusion: HDL cholesterol and apolipoprotein A1 levels had a strong, positive correlation with small artery reactive hyperaemia, whereas smoking, waist circumference and triglyceride levels were inversely associated. HDL cholesterol was the main determinant of RHI in small peripheral resistance arteries. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
C1 [Ferre, Raimon] Univ Rovira & Virgili, St Joan Univ Hosp, Fac Med, Vasc Med & Metab Unit,IISPV, Reus 43201, Spain.
   [Ferre, Raimon; Aragones, Gemma; Plana, Nuria; Merino, Jordi; Heras, Merche; Buixadera, Carme; Masana, Luis] Univ Rovira & Virgili, St Joan Univ Hosp, Res Unit Lipids & Atherosclerosis, E-43201 Reus, Spain.
   [Ferre, Raimon; Aragones, Gemma; Plana, Nuria; Merino, Jordi; Heras, Merche; Buixadera, Carme; Masana, Luis] Spanish Biomed Res Network Diabet & Associated Me, Barcelona, Spain.
C3 Universitat Rovira i Virgili; Institut d'Investigacio Sanitaria Pere
   Virgili (IISPV); Universitat Rovira i Virgili
RP Ferré, R (corresponding author), Univ Rovira & Virgili, St Joan Univ Hosp, Fac Med, Vasc Med & Metab Unit,IISPV, C St Joan S-N, Reus 43201, Spain.
EM rferre@grupsagessa.cat
RI MASANA, LUIS/M-7002-2019; Merino, Jordi/AAH-6853-2019; Aragones,
   Gemma/A-9693-2013
OI Plana, Nuria/0000-0002-4231-7618; Heras, Mercedes/0000-0002-5285-154X;
   Merino, Jordi/0000-0001-8312-1438; Masana, Luis/0000-0002-0789-4954;
   Aragones, Gemma/0000-0002-1924-9231
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NR 24
TC 23
Z9 24
U1 0
U2 8
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0021-9150
J9 ATHEROSCLEROSIS
JI Atherosclerosis
PD MAY
PY 2011
VL 216
IS 1
BP 115
EP 119
DI 10.1016/j.atherosclerosis.2011.01.039
PG 5
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 758YV
UT WOS:000290205800018
PM 21367423
OA Bronze
DA 2025-06-11
ER

PT J
AU Marchlewicz, M
   Sagan, P
   Grabowska, M
   Kiedrowicz, M
   Kruk, J
   Gill, K
   Piasecka, M
   Duchnik, E
AF Marchlewicz, Mariola
   Sagan, Paulina
   Grabowska, Marta
   Kiedrowicz, Magdalena
   Kruk, Joanna
   Gill, Kamil
   Piasecka, Malgorzata
   Duchnik, Ewa
TI The Role of Vitamin D3 Deficiency and Colonization of the Oral Mucosa by
   Candida Yeast-like Fungi in the Pathomechanism of Psoriasis
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Review
DE psoriasis; vitamin D3; oral mucosa; Candida
ID NEUTROPHIL EXTRACELLULAR TRAPS; PATTERN-RECOGNITION RECEPTOR; DERMAL
   DENDRITIC CELLS; PHYSICAL-ACTIVITY; KOEBNER PHENOMENON; OXIDATIVE
   STRESS; SKIN; IMMUNITY; RISK; PATHOGENESIS
AB Psoriasis is a chronic inflammatory skin disease with complex pathogenesis and variable severity. Performed studies have indicated the impact of vitamin D3 deficiency on the pathogenesis of psoriasis and its severity. However, there is no clear evidence of the influence of the mucosal microbiome on the onset and progression of psoriasis. This review aims to present the current evidence on the role of vitamin D3 and colonization of the oral mucosa by Candida yeast-like fungi in the pathogenesis of psoriasis. Candida albicans is a common yeast that can colonize the skin and mucosal surfaces, particularly in individuals with weakened immune systems or compromised skin barriers. In psoriasis, the skin's barrier function is disrupted, potentially making patients more susceptible to fungal infections such as Candida. Since patients with psoriasis are at increased risk of metabolic syndrome, they may experience the vicious circle effect in which chronic inflammation leads to obesity. Vitamin D3 deficiency is also associated with microbiological imbalance, which may promote excessive growth of Candida fungi. Under normal conditions, the intestinal and oral microflora support the immune system. Vitamin D3 deficiency, however, leads to disruption of this balance, which allows Candida to overgrow and develop infections.
C1 [Marchlewicz, Mariola; Sagan, Paulina; Kiedrowicz, Magdalena] Pomeranian Med Univ, Fac Hlth Sci, Dept Dermatol & Venereol, PL-70010 Police, Poland.
   [Grabowska, Marta; Gill, Kamil; Piasecka, Malgorzata] Pomeranian Med Univ, Fac Hlth Sci, Dept Histol & Dev Biol, PL-71210 Szczecin, Poland.
   [Kruk, Joanna] Univ Szczecin, Fac Phys Culture & Hlth, PL-71065 Szczecin, Poland.
   [Duchnik, Ewa] Pomeranian Med Univ, Fac Hlth Sci, Dept Aesthet Dermatol, PL-70111 Szczecin, Poland.
C3 Pomeranian Medical University; Pomeranian Medical University; University
   of Szczecin; Pomeranian Medical University
RP Grabowska, M (corresponding author), Pomeranian Med Univ, Fac Hlth Sci, Dept Histol & Dev Biol, PL-71210 Szczecin, Poland.
EM mariola.marchlewicz@pum.edu.pl; wietrakp@wp.pl;
   marta.grabowska@pum.edu.pl; magdalena.kiedrowicz@pum.edu.pl;
   joanna-szczecin@wp.pl; kamil.gill@pum.edu.pl;
   malgorzata.piasecka@pum.edu.pl; ewa.duchnik@pum.edu.pl
RI Duchnik, Ewa/C-6392-2017; Grabowska, Marta/AAT-9189-2021; Kiedrowicz,
   Magdalena/A-5510-2015; Piasecka, Malgorzata/A-9894-2015; Grabowska,
   Marta/N-3641-2014; Gill, Kamil/C-2841-2016
OI Piasecka, Malgorzata/0000-0002-5914-2121; Grabowska,
   Marta/0000-0003-0861-0738; Gill, Kamil/0000-0002-1655-5065
FU Pomeranian Medical University [WNoZ-324/S/2024]
FX This research was funded by the statutory budget of the Pomeranian
   Medical University No. WNoZ-324/S/2024.
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NR 115
TC 0
Z9 0
U1 1
U2 1
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD NOV
PY 2024
VL 13
IS 22
AR 6874
DI 10.3390/jcm13226874
PG 18
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA N6H9D
UT WOS:001365337700001
PM 39598018
OA gold
DA 2025-06-11
ER

PT J
AU Zhang, ZW
   Wang, Y
   Chen, XQ
   Wu, C
   Zhou, JY
   Chen, Y
   Liu, XJ
   Tang, XQ
AF Zhang, Zhewei
   Wang, Yu
   Chen, Xiangqi
   Wu, Chuan
   Zhou, Jingyue
   Chen, Yan
   Liu, Xiaojing
   Tang, Xiaoqiang
TI The aging heart in focus: The advanced understanding of heart failure
   with preserved ejection fraction
SO AGEING RESEARCH REVIEWS
LA English
DT Review
DE Aging; HFpEF; Pathology; Mechanism; Animal model; Therapeutics
ID PULMONARY ARTERIAL-HYPERTENSION; CARDIAC DIASTOLIC DYSFUNCTION; MOUSE
   MODEL; INFLAMMATION; HFPEF; STRESS; OBESITY; PATHOPHYSIOLOGY;
   CONSUMPTION; DEACETYLASE
AB Heart failure with preserved ejection fraction (HFpEF) accounts for 50 % of heart failure (HF) cases, making it the most common type of HF, and its prevalence continues to increase in the aging society. HFpEF is a systemic syndrome resulting from many risk factors, such as aging, metabolic syndrome, and hypertension, and its clinical features are highly heterogeneous in different populations. HFpEF syndrome involves the dysfunction of multiple organs, including the heart, lung, muscle, and vascular system. The heart shows dysfunction of various cells, including cardiomyocytes, endothelial cells, fibroblasts, adipocytes, and immune cells. The complex etiology and pathobiology limit experimental research on HFpEF in animal models, delaying a comprehensive understanding of the mechanisms and making treatment difficult. Recently, many scientists and cardiologists have attempted to improve the clinical outcomes of HFpEF. Recent advances in clinically related animal models and systemic pathology studies have improved our understanding of HFpEF, and clinical trials involving sodium-glucose cotransporter 2 inhibitors have significantly enhanced our confidence in treating HFpEF. This review provides an updated comprehensive discussion of the etiology and pathobiology, molecular and cellular mechanisms, preclinical animal models, and therapeutic trials in animals and patients to enhance our understanding of HFpEF and improve clinical outcomes.
C1 [Zhang, Zhewei; Wang, Yu; Wu, Chuan; Zhou, Jingyue; Tang, Xiaoqiang] Sichuan Univ, West China Univ Hosp 2,Key Lab Birth Defects & Rel, Natl Hlth Commiss Key Lab Chronobiol Dev & Related, Women & Children Key Lab Sichuan Prov,Childrens Me, Chengdu 610041, Peoples R China.
   [Zhang, Zhewei; Chen, Yan; Liu, Xiaojing] Sichuan Univ, Dept Cardiol, Chengdu 610041, Peoples R China.
   [Zhang, Zhewei; Chen, Yan; Liu, Xiaojing] Sichuan Univ, West China Hosp, Inst Cardiovasc Dis, Lab Cardiovasc Dis, Chengdu 610041, Peoples R China.
   [Zhang, Zhewei; Wang, Yu] Sichuan Univ, West China Sch Basic Med Sci & Forens Med, Chengdu 610041, Peoples R China.
   [Chen, Xiangqi] Sichuan Univ, West China Hosp, Inst Metab Dis & Pharmacotherapy, Dept Pharm, Chengdu 610041, Peoples R China.
C3 Sichuan University; Sichuan University; Sichuan University; Sichuan
   University; Sichuan University
RP Chen, Y; Liu, XJ (corresponding author), Sichuan Univ, West China Hosp, Chengdu 610041, Peoples R China.; Tang, XQ (corresponding author), Sichuan Univ, West China Univ Hosp 2, Chengdu 610041, Peoples R China.
EM chenyan0817@scu.edu.cn; liuxq@scu.edu.cn; tangxiaoqiang@scu.edu.cn
RI Wang, Yu/MVV-3490-2025; Tang, Xiaoqiang/G-4319-2013
OI Tang, Xiaoqiang/0000-0003-1314-3417
FU National Natural Science Foundation of China [82370235, 12072215];
   Sichuan Natural Science Foundation Outstanding Youth Science Foundation
   [2024NSFJQ0053]; Tianfu Qingcheng Plan [1711]
FX This work was supported by the National Natural Science Foundation of
   China (82370235, 12072215) , the Sichuan Natural Science Founda-tion
   Outstanding Youth Science Foundation (2024NSFJQ0053) , Tianfu Qingcheng
   Plan (no. 1711) . The authors thank Prof Yang Shen (Sichuan University,
   China) , Prof Yang Yang (Northwest University, China) and the reviewers
   for constructive suggestions. The figures were created using BioRender
   (http:// www.biorender.com /) .
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NR 230
TC 4
Z9 4
U1 13
U2 26
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 1568-1637
EI 1872-9649
J9 AGEING RES REV
JI Ageing Res. Rev.
PD NOV
PY 2024
VL 101
AR 102542
DI 10.1016/j.arr.2024.102542
EA OCT 2024
PG 31
WC Cell Biology; Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Geriatrics & Gerontology
GA J7V5P
UT WOS:001339102800001
PM 39396676
DA 2025-06-11
ER

PT J
AU Mbah, JI
   Bwititi, PT
   Gyawali, P
   Nwose, EU
AF Mbah, Jovita I.
   Bwititi, Phillip T.
   Gyawali, Prajwal
   Nwose, Ezekiel U.
TI Blood Viscosity Changes in Diabetes Mellitus: A 20-Year Bibliometric
   Review and Future Directions
SO CUREUS JOURNAL OF MEDICAL SCIENCE
LA English
DT Article
DE whole blood viscosity; progress report; conceptual &amp; empirical
   review; laboratory test; diabetes; cardiovascular complications
ID RISK; PREVALENCE; HYPERVISCOSITY; CAPILLARIES; PREVENTION; MANAGEMENT;
   THERAPY
AB Changes in hematological parameters due to diabetes are reflected in changes in whole blood viscosity (WBV). Understanding the impact of diabetes and its cardiovascular disease (CVD) complications can provide substantiation of how laboratory tests for WBV are useful to monitor the progression and treatment. The review examines research work done in the past 20 years to provide a framework for the present agenda. This was a narrative review that followed the standard Scale for the Assessment of Narrative Review Articles (SANRA) approach. It includes both conceptual and empirical reviews. WBV was appraised in the context of bibliographic research on diabetes and other related factors such as metabolic syndrome (MetS) and oxidative stress. The association of abnormal erythrocytes as well as the relationship between WBV and MetS is established. Changes in diabetes that contribute to the development of diabetic cardiovascular complications occur through the pathway of WBV physiology. However, longitudinal analysis is very limited. There is a dearth of longitudinal study data on WBV in diabetes management. This lack of data justifies a need for further studies, especially prospective and retrospective analysis, to investigate the prevalence of diabetes mellitus about the prevalence of cardiovascular complications indices, especially estimated WBV (eWBV) between periods and within cohorts.
C1 [Mbah, Jovita I.; Gyawali, Prajwal] Univ Southern Queensland, Sch Hlth & Med Sci, Toowoomba, Australia.
   [Bwititi, Phillip T.] Charles Sturt Univ, Dent & Med Sci, Albury, NSW, Australia.
   [Nwose, Ezekiel U.] Novena Univ, Publ & Community Hlth, Amai Campus, Ogume, Nigeria.
   [Nwose, Ezekiel U.] Univ Southern Queensland, Hlth & Med Sci, Toowoomba, Australia.
C3 University of Southern Queensland; Charles Sturt University; University
   of Southern Queensland
RP Mbah, JI (corresponding author), Univ Southern Queensland, Sch Hlth & Med Sci, Toowoomba, Australia.
EM jovitambah15@gmail.com
RI Nwose, Ezekiel/I-1333-2018; Bwititi, Phillip/HTP-8025-2023
FU JIM at the University of Southern Queensland, Australia
FX Acknowledgements This work is part two of the literature for an ongoing
   doctorate research project by JIM at the University of Southern
   Queensland, Australia. The university has provided support with digital
   infrastructure.
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NR 55
TC 2
Z9 2
U1 0
U2 1
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
EI 2168-8184
J9 CUREUS J MED SCIENCE
JI Cureus J Med Sci
PD JUL 10
PY 2024
VL 16
IS 7
AR e64211
DI 10.7759/cureus.64211
PG 14
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA YL6W9
UT WOS:001268693100045
PM 39130872
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Onyango, AN
AF Onyango, Arnold N.
TI Endogenous ozone as a regular reactive oxygen species in (patho)
   physiology
SO ADVANCES IN REDOX RESEARCH
LA English
DT Article
DE Biological ozone; Medical ozone therapy; Ozone signaling; Physical
   activity; Nutraceutical; Polyoxide
ID NF-KAPPA-B; PROTEIN-KINASE ACTIVATION; NADPH OXIDASE 5; URIC-ACID;
   NITRIC-OXIDE; SINGLET-OXYGEN; MACROPHAGE POLARIZATION; OXIDATIVE STRESS;
   IMMUNE-RESPONSE; EPITHELIAL-CELLS
AB Inhalation of tropospheric ozone increases the risk of respiratory diseases and the metabolic syndrome (MS). On the other hand, medical ozone therapy is used in the management of many chronic diseases including components of MS. However, medical ozone has not gained universal acceptance because the mechanisms involved therein are not fully understood. Ozone has also been reported to be endogenously formed in cells and organisms. Like medical ozone, endogenous ozone has not been fully embraced, due to limited understanding of the mechanisms of its formation. This review seeks to improve our understanding of the mechanisms of endogenous ozone formation by outlining previously proposed mechanisms, and suggesting new pathways based on reactions that have been reported to be involved in tropospheric ozone formation and electrochemical ozone production from water. New perspectives on the mechanisms of the harms of ozone inhalation and the benefits of medical ozone are discussed. It is hypothesized that endogenous ozone is involved in the harmful effects of particulate matter and ozone inhalation, as well as the benefits of medical ozone, nutraceuticals and physical activity. Thus, endogenous ozone should be regarded as a mainstream reactive oxygen species in redox biology.
C1 [Onyango, Arnold N.] Jomo Kenyatta Univ Agr & Technol, Sch Food & Nutr Sci, POB 62000, Nairobi 00200, Kenya.
C3 Jomo Kenyatta University of Agriculture & Technology
RP Onyango, AN (corresponding author), Jomo Kenyatta Univ Agr & Technol, Sch Food & Nutr Sci, POB 62000, Nairobi 00200, Kenya.
EM arnold.onyango@jkuat.ac.ke
OI Onyango, Arnold/0000-0003-2078-6496
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NR 389
TC 2
Z9 2
U1 2
U2 3
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
EI 2667-1379
J9 ADV REDOX RES
JI Adv. Redox Res.
PD DEC
PY 2023
VL 9
AR 100075
DI 10.1016/j.arres.2023.100075
PG 23
WC Biochemistry & Molecular Biology
WE Emerging Sources Citation Index (ESCI)
SC Biochemistry & Molecular Biology
GA L6Q3T
UT WOS:001351939400012
OA gold
DA 2025-06-11
ER

PT J
AU Martinez-Montoro, JI
   Cornejo-Pareja, I
   Gomez-Perez, AM
   Tinahones, FJ
AF Martinez-Montoro, Jose Ignacio
   Cornejo-Pareja, Isabel
   Gomez-Perez, Ana Maria
   Tinahones, Francisco J.
TI Impact of Genetic Polymorphism on Response to Therapy in Non-Alcoholic
   Fatty Liver Disease
SO NUTRIENTS
LA English
DT Review
DE non-alcoholic fatty liver disease; gene polymorphism; dietary
   intervention; gene-nutrient interactions; bariatric surgery;
   pharmacotherapy
ID DE-NOVO LIPOGENESIS; WEIGHT-LOSS; METABOLIC SYNDROME; PNPLA3 P.I148M;
   OMEGA-3 SUPPLEMENTATION; RS738409 POLYMORPHISM; INSULIN-RESISTANCE;
   BARIATRIC SURGERY; OXIDATIVE STRESS; I148M VARIANT
AB In the last decades, the global prevalence of non-alcoholic fatty liver disease (NAFLD) has reached pandemic proportions with derived major health and socioeconomic consequences; this tendency is expected to be further aggravated in the coming years. Obesity, insulin resistance/type 2 diabetes mellitus, sedentary lifestyle, increased caloric intake and genetic predisposition constitute the main risk factors associated with the development and progression of the disease. Importantly, the interaction between the inherited genetic background and some unhealthy dietary patterns has been postulated to have an essential role in the pathogenesis of NAFLD. Weight loss through lifestyle modifications is considered the cornerstone of the treatment for NAFLD and the inter-individual variability in the response to some dietary approaches may be conditioned by the presence of different single nucleotide polymorphisms. In this review, we summarize the current evidence on the influence of the association between genetic susceptibility and dietary habits in NAFLD pathophysiology, as well as the role of gene polymorphism in the response to lifestyle interventions and the potential interaction between nutritional genomics and other emerging therapies for NAFLD, such as bariatric surgery and several pharmacologic agents.
C1 [Martinez-Montoro, Jose Ignacio; Gomez-Perez, Ana Maria] Virgen Victoria Univ Hosp, Dept Endocrinol & Nutr, Malaga 29010, Spain.
   [Martinez-Montoro, Jose Ignacio; Tinahones, Francisco J.] Univ Malaga, Fac Med, Malaga 29071, Spain.
   [Cornejo-Pareja, Isabel; Tinahones, Francisco J.] Virgen Victoria Univ Hosp, Inst Invest Biomed Malaga IBIMA, Malaga 29010, Spain.
   [Cornejo-Pareja, Isabel; Tinahones, Francisco J.] Inst Salud Carlos III, Spanish Biomed Res Ctr Physiopathol Obes & Nutr C, Madrid 28029, Spain.
C3 Universidad de Malaga; Universidad de Malaga; Instituto de Investigacion
   Biomedica de Malaga y Plataforma en Nanomedicina (IBIMA); Instituto de
   Salud Carlos III
RP Gomez-Perez, AM (corresponding author), Virgen Victoria Univ Hosp, Dept Endocrinol & Nutr, Malaga 29010, Spain.; Cornejo-Pareja, I (corresponding author), Virgen Victoria Univ Hosp, Inst Invest Biomed Malaga IBIMA, Malaga 29010, Spain.; Cornejo-Pareja, I (corresponding author), Inst Salud Carlos III, Spanish Biomed Res Ctr Physiopathol Obes & Nutr C, Madrid 28029, Spain.
EM isabelmaria_cornejo@hotmail.com
RI Tinahones, Francisco/AAB-2882-2020; Martínez Montoro, José
   Ignacio/HJB-1505-2022
OI Tinahones, Francisco J/0000-0001-6871-4403; Gomez Perez, Ana
   Maria/0000-0002-2874-5894; Martinez- Montoro, Jose
   Ignacio/0000-0001-9761-6888
FU Spanish Ministry of Economy and Competitiveness (ISCIII); Fondo Europeo
   de Desarrollo Regional FEDER [CM 17/00169, JR 19/00054]; Servicio
   Andaluz de Salud [B-0033-2014]; "Centros de Investigacion Biomedica en
   Red" (CIBER) of the Institute of Health Carlos III (ISCIII)
   [CB06/03/0018]; ISCIII [PI18/01160]; European Regional Development Fund
   (ERDF)
FX I.C.-P. was supported by Rio Hortega and now for Juan Rodes from the
   Spanish Ministry of Economy and Competitiveness (ISCIII) and cofounded
   by Fondo Europeo de Desarrollo RegionalFEDER (CM 17/00169, JR 19/00054).
   A.M.G.-P. was supported by a research contract from Servicio Andaluz de
   Salud (B-0033-2014). This study was supported by the "Centros de
   Investigacion Biomedica en Red" (CIBER) of the Institute of Health
   Carlos III (ISCIII) (CB06/03/0018), and research grants from the ISCIII
   (PI18/01160) and co-financed by the European Regional Development Fund
   (ERDF).
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NR 124
TC 6
Z9 6
U1 1
U2 6
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD NOV
PY 2021
VL 13
IS 11
AR 4077
DI 10.3390/nu13114077
PG 15
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA XE9RH
UT WOS:000723718400001
PM 34836332
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Farzaei, MH
   Bahramsoltani, R
   Abbasabadi, Z
   Braidy, N
   Nabavi, SM
AF Farzaei, Mohammad Hosein
   Bahramsoltani, Roodabeh
   Abbasabadi, Zahra
   Braidy, Nady
   Nabavi, Seyed Mohammad
TI Role of green tea catechins in prevention of age-related cognitive
   decline: Pharmacological targets and clinical perspective
SO JOURNAL OF CELLULAR PHYSIOLOGY
LA English
DT Review
DE Alzheimer disease; catechins; cognitive decline; dementia; green tea;
   neurodegenerative disease; phenolic compounds; polyphenols
ID 5-HT6 RECEPTOR ANTAGONISTS; N-TERMINAL KINASE; ALZHEIMERS-DISEASE;
   EPIGALLOCATECHIN-3-GALLATE EGCG; ACETYLCHOLINESTERASE ACTIVITY;
   PARKINSONS-DISEASE; METABOLIC SYNDROME; INDUCED IMPAIRMENT; VASCULAR
   DEMENTIA; OXIDATIVE STRESS
AB Over the past decade, a wide range of scientific investigations have been performed to reveal neuropathological aspects of cognitive disorders; however, only limited therapeutic approaches currently exist. The failures of conventional therapeutic options as well as the predicted dramatic rise in the prevalence of cognitive decline in the coming future show the necessity for novel therapeutic agents. Recently, a wide range of research has focused on pharmacological activities of green tea catechins worldwide. Current investigations have clarified mechanistic effects of the catechins in inflammatory cascades, oxidative damages, different cellular transcription as well as transduction pathway in various body systems. It has been demonstrated that green tea polyphenols prevent age-related neurodegeneration through improvement of endogenous antioxidant defense mechanisms, modulation of neural growth factors, attenuation of neuroinflammatory pathway, and regulation of apoptosis. The catechins exhibited beneficial effects in cellular and animal models of neurodegenerative diseases including Alzheimer's disease, MS, and Parkinson's disease. The present review discusses the current pharmacological targets, which can be involved in the treatment of cognitive decline and addresses the action of catechin derivatives elicited from green tea on the multiple neural targets.
C1 [Farzaei, Mohammad Hosein] Kermanshah Univ Med Sci, Pharmaceut Sci Res Ctr, Kermanshah 6734667149, Iran.
   [Farzaei, Mohammad Hosein; Abbasabadi, Zahra] Kermanshah Univ Med Sci, Med Biol Res Ctr, Kermanshah, Iran.
   [Bahramsoltani, Roodabeh] Univ Tehran Med Sci, Sch Persian Med, Dept Pharm Persian Med, Tehran, Iran.
   USERN, PPIG, Tehran, Iran.
   [Braidy, Nady] Univ New South Wales, Sch Psychiat, Ctr Hlth Brain Ageing, Sydney, NSW, Australia.
   [Nabavi, Seyed Mohammad] Baqiyatallah Univ Med Sci, Appl Biotechnol Res Ctr, Tehran, Iran.
C3 Kermanshah University of Medical Sciences; Kermanshah University of
   Medical Sciences; Tehran University of Medical Sciences; University of
   New South Wales Sydney; Baqiyatallah University of Medical Sciences
   (BMSU)
RP Farzaei, MH (corresponding author), Kermanshah Univ Med Sci, Pharmaceut Sci Res Ctr, Kermanshah 6734667149, Iran.
EM mh.farzaei@gmail.com
RI Braidy, Nady/G-4928-2012; Nabavi, Seyed Mohammad/G-5335-2010; Farzaei,
   Mohammad/M-5779-2017; Bahramsoltani, Roodabeh/A-1001-2018
OI Farzaei, Mohammad Hosein/0000-0001-7081-6521; Braidy,
   Nady/0000-0002-0497-5572; Bahramsoltani, Roodabeh/0000-0001-6942-0546
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NR 126
TC 47
Z9 55
U1 0
U2 130
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0021-9541
EI 1097-4652
J9 J CELL PHYSIOL
JI J. Cell. Physiol.
PD MAR
PY 2019
VL 234
IS 3
BP 2447
EP 2459
DI 10.1002/jcp.27289
PG 13
WC Cell Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Physiology
GA HC2FU
UT WOS:000451618500043
PM 30187490
DA 2025-06-11
ER

PT J
AU Paiva, CLRS
   Beserra, BTS
   Reis, CEG
   Dorea, JG
   Da Costa, THM
   Amato, AA
AF Paiva, C. L. R. S.
   Beserra, B. T. S.
   Reis, C. E. G.
   Dorea, J. G.
   Da Costa, T. H. M.
   Amato, A. A.
TI Consumption of coffee or caffeine and serum concentration of
   inflammatory markers: A systematic review
SO CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
LA English
DT Review
DE Inflammatory markers; inflammatory response; coffee; caffeine
ID ALL-CAUSE MORTALITY; METABOLIC SYNDROME; RISK; ASSOCIATION; HEALTHY;
   BIOMARKERS; STRESS; TRIGONELLINE; DRINKING; OBESITY
AB Coffee consumption is associated with reduced risk of conditions that share low-grade inflammation as their physiopathological basis. We therefore summarized the effects of coffee or coffee components on serum levels of inflammatory markers. Clinical trials assessing the effect of coffee, caffeine or other coffee components on inflammatory markers were searched without restriction to publication date. Fifteen studies (8 involving coffee and 7 caffeine) were included. Increased adiponectin levels were found in four of seven trials comparing filtered coffee/caffeinated coffee with placebo or comparing its levels at baseline and after consumption of medium or dark roasted coffee, but no change was seen in caffeine trials. None of the five studies assessing the effects of coffee found changes in C-reactive protein (CPR), but one out of three trials found decreased CPR levels in response to caffeine. Interleukin (IL)-6 was increased by caffeinated coffee compared with placebo in one of four coffee trials, and by caffeine in three out of five studies. Caffeine increased IL-10 levels in two of three trials. These data suggest a predominant anti-inflammatory action of coffee but not of caffeine consumption. Moreover, the proinflammatory and anti-inflammatory responses to caffeine point to its complex effects on the inflammatory response.
C1 [Paiva, C. L. R. S.; Beserra, B. T. S.; Amato, A. A.] Univ Brasilia, Sch Hlth Sci, Dept Pharmaceut Sci, Lab Mol Pharmacol, Brasilia, DF, Brazil.
   [Reis, C. E. G.; Dorea, J. G.; Da Costa, T. H. M.] Univ Brasilia, Sch Hlth Sci, Dept Nutr, Lab Biochem Nutr, Brasilia, DF, Brazil.
C3 Universidade de Brasilia; Universidade de Brasilia
RP Paiva, CLRS; Beserra, BTS; Amato, AA (corresponding author), Univ Brasilia, Fac Ciencias Saude, Lab Farmacol Mol, Campus Univ Darcy Ribeiro, BR-71910900 Brasilia, DF, Brazil.; Reis, CEG; Dorea, JG; Da Costa, THM (corresponding author), Univ Brasilia, Nucleo Nutr, Lab Bioquim Nutr, BR-71910900 Brasilia, DF, Brazil.
EM ciciliarocha@yahoo.com.br; brunna_telless@hotmail.com;
   caioedureis@gmail.com; jg.dorea@gmail.com; thmdacosta@gmail.com;
   angelicamato@unb.br
RI Reis, Caio/O-1889-2013; da Costa, Teresa/H-8434-2013
OI Reis, Caio/0000-0001-7260-9497
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NR 71
TC 58
Z9 60
U1 3
U2 31
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1040-8398
EI 1549-7852
J9 CRIT REV FOOD SCI
JI Crit. Rev. Food Sci. Nutr.
PD FEB 21
PY 2019
VL 59
IS 4
BP 652
EP 663
DI 10.1080/10408398.2017.1386159
PG 12
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA HT4ZG
UT WOS:000464571300009
PM 28967799
DA 2025-06-11
ER

PT J
AU Aroor, AR
   Jia, GH
   Sowers, JR
AF Aroor, Annayya R.
   Jia, Guanghong
   Sowers, James R.
TI Cellular mechanisms underlying obesity-induced arterial stiffness
SO AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE
   PHYSIOLOGY
LA English
DT Review
DE cardiorenal metabolic syndrome; cardiovascular disease; cardiovascular
   stiffness; Western diet
ID PERIVASCULAR ADIPOSE-TISSUE; NITRIC-OXIDE SYNTHASE; GLYCATION
   END-PRODUCTS; VASCULAR INSULIN-RESISTANCE; AORTIC STIFFNESS;
   MINERALOCORTICOID RECEPTOR; WESTERN DIET; ENDOTHELIAL DYSFUNCTION;
   DIASTOLIC DYSFUNCTION; MOLECULAR-MECHANISMS
AB Obesity is an emerging pandemic driven by consumption of a diet rich in fat and highly refined carbohydrates (a Western diet) and a sedentary lifestyle in both children and adults. There is mounting evidence that arterial stiffness in obesity is an independent and strong predictor of cardiovascular disease (CVD), cognitive functional decline, and chronic kidney disease. Cardiovascular stiffness is a precursor to atherosclerosis, systolic hypertension, cardiac diastolic dysfunction, and impairment of coronary and cerebral flow. Moreover, premenopausal women lose the CVD protection normally afforded to them in the setting of obesity, insulin resistance, and diabetes, and this loss of CVD protection is inextricably linked to an increased propensity for arterial stiffness. Stiffness of endothelial and vascular smooth muscle cells, extracellular matrix remodeling, perivascular adipose tissue inflammation, and immune cell dysfunction contribute to the development of arterial stiffness in obesity. Enhanced endothelial cortical stiffness decreases endothelial generation of nitric oxide, and increased oxidative stress promotes destruction of nitric oxide. Our research over the past 5 years has underscored an important role of increased aldosterone and vascular mineralocorticoid receptor activation in driving development of cardiovascular stiffness, especially in females consuming a Western diet. In this review the cellular mechanisms of obesity-associated arterial stiffness are highlighted.
C1 [Aroor, Annayya R.; Jia, Guanghong; Sowers, James R.] Univ Missouri, Sch Med, Diabet & Cardiovasc Ctr, Columbia, MO USA.
   [Sowers, James R.] Univ Missouri, Dept Med Pharmacol, Sch Med, Columbia, MO USA.
   [Sowers, James R.] Univ Missouri, Sch Med, Dept Physiol, Columbia, MO 65212 USA.
   [Aroor, Annayya R.; Jia, Guanghong; Sowers, James R.] Harry S Truman Mem Vet Hosp, Columbia, MO 65201 USA.
   [Sowers, James R.] Dalton Cardiovasc Ctr Columbia, Columbia, MO USA.
C3 University of Missouri System; University of Missouri Columbia;
   University of Missouri System; University of Missouri Columbia;
   University of Missouri System; University of Missouri Columbia; US
   Department of Veterans Affairs; Veterans Health Administration (VHA);
   Harry S. Truman Memorial Veterans' Hospital
RP Sowers, JR (corresponding author), Univ Missouri, D109 Diabet Ctr HSC,One Hosp Dr, Columbia, MO 65212 USA.
EM sowersj@health.missouri.edu
FU National Heart, Lung, and Blood Institute [HL-073101, HL-107910];
   Department of Veterans Affairs Biomedical Laboratory Research and
   Development Grant [0018]
FX This work was supported by National Heart, Lung, and Blood Institute
   Grants HL-073101 and HL-107910 (to J. R. Stanton) and Department of
   Veterans Affairs Biomedical Laboratory Research and Development Grant
   0018 (to J. R. Stanton).
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NR 149
TC 124
Z9 132
U1 1
U2 17
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0363-6119
EI 1522-1490
J9 AM J PHYSIOL-REG I
JI Am. J. Physiol.-Regul. Integr. Comp. Physiol.
PD MAR
PY 2018
VL 314
IS 3
BP R387
EP R398
DI 10.1152/ajpregu.00235.2016
PG 12
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA GP7PC
UT WOS:000441095300002
PM 29167167
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Li, S
   Wang, XM
   Zhang, JL
   Li, JY
   Liu, XG
   Ma, YY
   Han, C
   Zhang, LX
   Zheng, LL
AF Li, Shan
   Wang, Xiaoman
   Zhang, Jielei
   Li, Jingyi
   Liu, xiaogang
   Ma, Yuanyuan
   Han, Chao
   Zhang, Lixia
   Zheng, Lili
TI Exenatide ameliorates hepatic steatosis and attenuates fat mass and
   FTO gene expression through PI3K signaling pathway in
   nonalcoholic fatty liver disease
SO BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
LA English
DT Article
DE GLP-1; FTO; NAFLD; PI3K; Hepatic steatosis
ID PEPTIDE-1 RECEPTOR AGONISTS; BROWN ADIPOSE-TISSUE; INSULIN-RESISTANCE;
   OXIDATIVE STRESS; GLP-1; METABOLISM; SYSTEM; CELLS
AB Non-alcoholic fatty liver disease (NAFLD) is a common disease associated with metabolic syndrome and can lead to life-threatening complications like hepatic carcinoma and cirrhosis. Exenatide, a glucagon-like peptide-1 (GLP-1) receptor agonist antidiabetic drug, has the capacity to overcome insulin resistance and attenuate hepatic steatosis but the specific underlying mechanism is unclear. This study was designed to investigate the underlying molecular mechanisms of exenatide therapy on NAFLD. We used in vivo and in vitro techniques to investigate the protective effects of exenatide on fatty liver via fat mass and obesity associated gene (FTO) in a high-fat (HF) diet-induced NAFLD animal model and related cell culture model. Exenatide significantly decreased body weight, serum glucose, insulin, insulin resistance, serum free fatty acid, triglyceride, total cholesterol, low-density lipoprotein, aspartate aminotransferase, and alanine aminotransferase levels in HF-induced obese rabbits. Histological analysis showed that exenatide significantly reversed HF-induced lipid accumulation and inflammatory changes accompanied by decreased FTO mRNA and protein expression, which were abrogated by PI3K inhibitor LY294002. This study indicated that pharmacological interventions with GLP-1 may represent a promising therapeutic strategy for NAFLD.
C1 [Li, Shan; Wang, Xiaoman; Zhang, Jielei; Liu, xiaogang; Ma, Yuanyuan; Zhang, Lixia; Zheng, Lili] Zhengzhou Univ, Affiliated Hosp 1, Dept Endocrinol, Zhengzhou, Henan, Peoples R China.
   [Li, Jingyi] Zhengzhou Univ, Affiliated Hosp 1, Dept Breast Surg, Zhengzhou, Henan, Peoples R China.
   [Han, Chao] Zhengzhou Univ, Affiliated Hosp 1, Dept Pharm, Zhengzhou, Henan, Peoples R China.
C3 Zhengzhou University; Zhengzhou University; Zhengzhou University
RP Zheng, LL (corresponding author), Zhengzhou Univ, Affiliated Hosp 1, Dept Endocrinol, Zhengzhou, Henan, Peoples R China.
EM 2837539146@qq.com
RI Zheng, Lili/LHA-0367-2024; Liu, Xiaogang/GOP-1840-2022; chao,
   han/JDD-4292-2023; wang, xiaoman/GQH-0836-2022
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NR 28
TC 30
Z9 37
U1 2
U2 11
PU ASSOC BRAS DIVULG CIENTIFICA
PI RIBEIRAO PRETO
PA FACULDADE MEDICINA, CASA 10, 14049 RIBEIRAO PRETO, RIBEIRAO PRETO, SP
   14049, BRAZIL
SN 0100-879X
EI 1678-4510
J9 BRAZ J MED BIOL RES
JI Brazilian J. Med. Biol. Res.
PY 2018
VL 51
IS 8
AR e7299
DI 10.1590/1414-431X20187299
PG 10
WC Biology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics; Research & Experimental
   Medicine
GA GJ7DL
UT WOS:000435545200001
PM 29924135
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Nasri, R
   Abdelhedi, O
   Jemil, I
   Ben Amor, I
   Elfeki, A
   Gargouri, J
   Boualga, A
   Karra-Châabouni, M
   Nasri, M
AF Nasri, Rim
   Abdelhedi, Ola
   Jemil, Ines
   Ben Amor, Ikram
   Elfeki, Abdelfattah
   Gargouri, Jalel
   Boualga, Ahmed
   Karra-Chaabouni, Maha
   Nasri, Moncef
TI Preventive effect of goby fish protein hydrolysates on hyperlipidemia
   and cardiovascular disease in Wistar rats fed a high-fat/fructose diet
SO RSC ADVANCES
LA English
DT Article
ID LIPID PROFILE; METABOLIC SYNDROME; OXIDATIVE STRESS; HIGH-FRUCTOSE;
   CHOLESTEROL; PLASMA; PEPTIDES; SUPPLEMENTATION; ADIPOSITY; EXTRACT
AB This study was carried out to investigate the hypolipidemic, cardioprotective and anticoagulant properties of fish goby protein hydrolysates (GPHs) in rats fed a high fat and fructose diet (HFFD). Wistar rats were fed with HFFD for 2 months, coupled with the oral administration of GPHs and undigested goby protein (UGP). Compared with the standard diet, HFFD induced dyslipidemia and liver structure alterations, and increased pancreatic lipase activity. In addition, HFFD caused a significant increase in body weight. Interestingly, administration of UGP and GPHs to HFFD fed rats was efficacious in lowering serum total cholesterol (TC), triglyceride (TG) and low-density lipoprotein cholesterol (LDL-c) as well as hepatic TC and TG, and increased the serum high density lipoprotein cholesterol (HDL-c) content. Moreover, all treatments significantly decreased the atherogenic index and coagulant factor levels (thrombin and prothrombin). UGP and GPH administration also significantly decreased pancreatic lipase activity, which mitigates lipid accumulation. Similarly, UGP and its hydrolysates showed cardioprotective potential revealed by decreasing the risk of atherogenic and coronary artery disease and improving the liver architecture. The ex vivo plasma clotting test showed that GPHs exert a great therapeutic anticoagulant potential. The overall results demonstrated that GPH supplementation can counteract high-fat/fructose diet-induced obesity.
C1 [Nasri, Rim; Abdelhedi, Ola; Jemil, Ines; Karra-Chaabouni, Maha; Nasri, Moncef] Univ Sfax, Natl Sch Engn Sfax ENIS, Lab Enzyme Engn & Microbiol, POB 1173, Sfax 3038, Tunisia.
   [Elfeki, Abdelfattah] Univ Sfax, Fac Sci Sfax, Lab Anim Ecophysiol, POB 95, Sfax 3052, Tunisia.
   [Boualga, Ahmed] Univ Oran, Fac Sci Nat & Vie, Lab Nutr Clin & Metab, 1 Ahmed Ben Bella, Oran, Algeria.
   [Ben Amor, Ikram; Gargouri, Jalel] Ctr Reg Transfus Sanguine Sfax, Route El Ain Km 0-5,CP 3003, Sfax, Tunisia.
C3 Universite de Sfax; Ecole Nationale dIngenieurs de Sfax (ENIS);
   Universite de Sfax; Faculty of Sciences Sfax; Universite d'Oran;
   Universite de Sfax
RP Abdelhedi, O (corresponding author), Univ Sfax, Natl Sch Engn Sfax ENIS, Lab Enzyme Engn & Microbiol, POB 1173, Sfax 3038, Tunisia.
EM abd.ola1502@gmail.com
RI Abdelhedi, Ola/ABC-1744-2020; elfeki, abdelfattah/LKL-6561-2024;
   BOUALGA, Ahmed/AAB-1706-2019
OI BOUALGA, Ahmed/0000-0003-2640-7231; elfeki,
   abdelfattah/0009-0009-9949-1367; Abdelhedi, Ola/0000-0001-6829-0014
FU Ministry of Higher Education and Scientific Research
FX This work was funded by the Ministry of Higher Education and Scientific
   Research.
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NR 59
TC 21
Z9 21
U1 0
U2 14
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2046-2069
J9 RSC ADV
JI RSC Adv.
PY 2018
VL 8
IS 17
BP 9383
EP 9393
DI 10.1039/c7ra13102j
PG 11
WC Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry
GA GF4ZD
UT WOS:000431972600043
PM 35541829
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Macut, D
   Bjekic-Macut, J
   Rahelic, D
   Doknic, M
AF Macut, Djuro
   Bjekic-Macut, Jelica
   Rahelic, Dario
   Doknic, Mirjana
TI Insulin and the polycystic ovary syndrome
SO DIABETES RESEARCH AND CLINICAL PRACTICE
LA English
DT Review
DE Insulin; Insulin resistance; Polycystic ovary syndrome; Androgens;
   Metformin
ID IMPAIRED GLUCOSE-TOLERANCE; TYPE-2 DIABETES-MELLITUS; FATTY
   LIVER-DISEASE; SYNDROME PCOS; NONOBESE WOMEN; OXIDATIVE STRESS; ANDROGEN
   EXCESS; ADIPOSE-TISSUE; OBESE WOMEN; RESISTANCE
AB Polycystic ovary syndrome ( PCOS) is the most prevalent endocrinopathy among women during reproductive age. PCOS is characterised by hyperandrogenaemia, hyperinsulinaemia, and deranged adipokines secretion from the adipose tissue. In addition to the reduced insulin sensitivity, PCOS women exhibit beta-cell dysfunction as well. Low birth weight and foetal exposure to androgens may contribute to the development of the PCOS phenotype during life. Further metabolic complications lead to dyslipidaemia, worsening obesity and glucose tolerance, high prevalence of metabolic syndrome, and greater susceptibility to diabetes. PCOS women show age-related existence of hypertension, and subtle endothelial and vascular changes. Adverse reproductive outcomes include anovulatory infertility, and unrecognised potentiation of the hormone-dependent endometrial cancer. The main therapeutic approach is lifestyle modification. Metformin is the primary insulin-sensitising drug to be used as an adjuvant therapy to lifestyle modification in patients with insulin resistance and impaired glucose tolerance, as well as in those referred to infertility treatment. Thiazolidinediones should be reserved for women intolerant of or refractory to metformin, while glucagon-like peptide 1 analogues has a potential therapeutic use in obese PCOS women. Randomised clinical trials and repetitive studies on different PCOS phenotypes for the preventive actions and therapeutic options are still lacking, though. (C) 2017 Elsevier B.V. All rights reserved.
C1 [Macut, Djuro; Doknic, Mirjana] Univ Belgrade, Clin Endocrinol Diabet & Metab Dis, Fac Med, Belgrade, Serbia.
   [Bjekic-Macut, Jelica] Univ Belgrade, Fac Med, UMC Bezanijska Kosa, Dept Endocrinol, Belgrade, Serbia.
   [Rahelic, Dario] Dubrava Univ Hosp, Sch Med Zagreb, Clin Internal Med, Dept Endocrinol Diabet & Clin Pharmacol, Zagreb, Croatia.
C3 University of Belgrade; University of Belgrade; University of Zagreb;
   UNIVERSITY ZAGREB HOSPITAL
RP Macut, D (corresponding author), Clin Endocrinol Diabet & Metab Dis, Dr Subotica 13, Belgrade 11000, Serbia.
EM djmacut@gmail.com
RI Rahelic, Dario/AAL-5736-2020
FU Serbian Ministry of Education, Science and Technological Development
   [41009, 175032]
FX This work was supported by the Serbian Ministry of Education, Science
   and Technological Development [Grant Nos. 41009, 175032].
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NR 79
TC 164
Z9 174
U1 0
U2 36
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0168-8227
EI 1872-8227
J9 DIABETES RES CLIN PR
JI Diabetes Res. Clin. Pract.
PD AUG
PY 2017
VL 130
BP 163
EP 170
DI 10.1016/j.diabres.2017.06.011
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA FB9LK
UT WOS:000406460400022
PM 28646699
DA 2025-06-11
ER

PT J
AU Tai, CJ
   Choong, CY
   Lin, YC
   Shi, YC
   Tai, CJ
AF Tai, Chen-Jei
   Choong, Chen-Yen
   Lin, Yu-Chun
   Shi, Yeu-Ching
   Tai, Cheng-Jeng
TI The anti-hepatic fibrosis activity of ergosterol depended on
   upregulation of PPARgamma in HSC-T6 cells
SO FOOD & FUNCTION
LA English
DT Article
ID GLYCATION END-PRODUCTS; EPITHELIAL-MESENCHYMAL TRANSITION; OXIDATIVE
   STRESS; STELLATE CELLS; ANTRODIA-CAMPHORATA; TISSUE INHIBITOR;
   GENE-EXPRESSION; MOUSE MODEL; RECEPTOR; INFLAMMATION
AB Advanced glycation endproducts (AGEs) were shown to play an important role in metabolic syndrome and were suggested to contribute to the development of hepatic fibrosis. Evidence indicates that AGEs resulted in hepatic fibrosis coupled to the activation of the receptor for AGEs (RAGE) in hepatic stellate cells (HSCs). NADPH oxidase is downstream of the RAGE signaling pathway, resulting in an increase in reactive oxygen species (ROS), alpha-smooth muscle actin (alpha-SMA), RAGE, and matrix metalloproteinase-9 (MMP-9). This study was designed to evaluate the effects of ergosterol on RAGE signaling in HSC-T6 cells. Ergosterol suppressed the activation of HSC-T6 cells induced by AGEs, and attenuated overexpressions of alpha-SMA, MMP-9, and epithelial-mesenchymal transition (EMT) markers, including N-cadherin and vimentin. We also found that these inhibitory effects of ergosterol on the activation of HSCs were dependent on peroxisome proliferator-activated receptor-gamma (PPARgamma) confirmed by PPARgamma reporter assay and PPARgamma knockdown. In addition, ergosterol also showed an inhibitory effect on the generation of AGEs, fructosamine, and a-dicarbonyl compounds in this study. Our results show that ergosterol can be used as a protective agent against hepatic fibrosis caused by induction of AGEs.
C1 [Tai, Chen-Jei; Choong, Chen-Yen] Taipei Med Univ, Sch Med, Coll Med, Dept Obstet & Gynecol, Taipei 11031, Taiwan.
   [Tai, Chen-Jei] Taipei Med Univ Hosp, Dept Chinese Med, Taipei 11031, Taiwan.
   [Tai, Chen-Jei] Taipei Med Univ Hosp, Tradit Herbal Med Res Ctr, Taipei 11031, Taiwan.
   [Lin, Yu-Chun] Taipei Med Univ Hosp, Grad Inst Med Sci, Taipei 11031, Taiwan.
   [Shi, Yeu-Ching; Tai, Cheng-Jeng] Taipei Med Univ Hosp, Dept Internal Med, Div Hematol & Oncol, Taipei 11031, Taiwan.
   [Tai, Cheng-Jeng] Taipei Med Univ, Sch Med, Dept Internal Med, Div Hematol & Oncol,Coll Med, Taipei 11031, Taiwan.
   [Shi, Yeu-Ching] Taiwan Indigena Bot Co Ltd, Taipei 11494, Taiwan.
C3 Taipei Medical University; Taipei Medical University Hospital; Taipei
   Medical University; Taipei Medical University; Taipei Medical University
   Hospital; Taipei Medical University; Taipei Medical University Hospital;
   Taipei Medical University Hospital; Taipei Medical University; Taipei
   Medical University
RP Shi, YC; Tai, CJ (corresponding author), Taipei Med Univ Hosp, Dept Internal Med, Div Hematol & Oncol, Taipei 11031, Taiwan.; Tai, CJ (corresponding author), Taipei Med Univ, Sch Med, Dept Internal Med, Div Hematol & Oncol,Coll Med, Taipei 11031, Taiwan.; Shi, YC (corresponding author), Taiwan Indigena Bot Co Ltd, Taipei 11494, Taiwan.
EM cjtai@tmu.edu.tw; ycshi@healthtib.com
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NR 40
TC 13
Z9 14
U1 0
U2 13
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PY 2016
VL 7
IS 4
BP 1915
EP 1923
DI 10.1039/c6fo00117c
PG 9
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA DK3BM
UT WOS:000374790000021
PM 27040153
DA 2025-06-11
ER

PT J
AU Macongonde, EA
   Costa, NLF
   Ferreira, BK
   Biella, MS
   Frederico, MJS
   De Oliveira, MR
   Avila, S
   Silva, FRMB
   Ferreira, GC
   Streck, EL
   Schuck, PF
AF Macongonde, Ernesto A.
   Costa, Naithan L. F.
   Ferreira, Bruna K.
   Biella, Mairis S.
   Frederico, Marisa J. S.
   De Oliveira, Marcos R.
   Avila Junior, Silvio
   Silva, Fatima R. M. B.
   Ferreira, Gustavo C.
   Streck, Emilio L.
   Schuck, Patricia F.
TI Neutrotoxic effects of fructose administration in rat brain:
   implications for fructosemia
SO ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS
LA English
DT Article
DE brain damage; fructose; fructosemia; hereditary fructose intolerance;
   Krebs cycle; metabolism
ID INDUCED INSULIN-RESISTANCE; CEREBROSPINAL-FLUID; MULTIPLE-SCLEROSIS;
   METABOLIC SYNDROME; OXIDATIVE STRESS; SUCROSE; TRANSTHYRETIN;
   INTOLERANCE; DISEASE; HYPERTENSION
AB Fructose accumulates in tissue and body fluids of patients affected by hereditary fructose intolerance (HFI), a disorder caused by the deficiency of aldolase B. We investigated the effect of acute fructose administration on the biochemical profile and on the activities of the Krebs cycle enzymes in the cerebral cortex of young rats. Rats received a subcutaneous injection of NaCl (0.9 %; control group) or fructose solution (5 mu mol/g; treated group). Twelve or 24 h after the administration, the animals were euthanized and the cerebral cortices were isolated. Peripheral blood (to obtain the serum) and cerebral spinal fluid (CSF) from the animals were also collected. It was observed that albumin levels were decreased and cholesterol levels were increased in CSF of animals 12 h after the administration of fructose. In addition, serum lactate levels were increased 12 h after the administration, as compared to control group. Furthermore, malate dehydrogenase activity was increased in cerebral cortex from treated group 24 h after the administration of this carbohydrate. Herein we demonstrate that fructose administration alters biochemical parameters in CSF and serum and bioenergetics parameters in the cerebral cortex. These findings indicate a possible role of fructose on brain alterations found in HFI patients.
C1 [Macongonde, Ernesto A.; Costa, Naithan L. F.; Ferreira, Bruna K.; Biella, Mairis S.; Avila Junior, Silvio; Schuck, Patricia F.] Univ Extremo Sul Catarinense, Unidade Acad Ciencias Saude, Lab Erros Inatos Metab, BR-88806000 Criciuma, SC, Brazil.
   [Frederico, Marisa J. S.; Silva, Fatima R. M. B.] Univ Fed Santa Catarina, Dept Bioquim, Lab Hormonios & Transducao Sinais, BR-88037100 Florianopolis, SC, Brazil.
   [De Oliveira, Marcos R.] Univ Fed Mato Grosso, Inst Ciencias Exatas & Terra, Dept Quim, BR-78060900 Cuiaba, MT, Brazil.
   [Ferreira, Gustavo C.] Univ Fed Rio de Janeiro, Inst Bioquim Med Leopoldo de Meis, Lab Bioenerget, BR-21941902 Rio De Janeiro, RJ, Brazil.
   [Streck, Emilio L.] Univ Extremo Sul Catarinense, Unidade Acad Ciencias Saude, Lab Bioenerget, BR-88806000 Criciuma, SC, Brazil.
C3 Universidade do Extremo Sul Catarinense; Universidade Federal de Santa
   Catarina (UFSC); Universidade Federal de Mato Grosso; Universidade
   Federal do Rio de Janeiro; Universidade do Extremo Sul Catarinense
RP Schuck, PF (corresponding author), Univ Extremo Sul Catarinense, Unidade Acad Ciencias Saude, Lab Erros Inatos Metab, Ave Univ 1105,Bloco S,Sala 6, BR-88806000 Criciuma, SC, Brazil.
EM patricia.schuck@pq.cnpq.br
RI Streck, Emilio/J-7558-2013; Silva, Fatima/S-7939-2019; Ferreira,
   Carlos/G-4957-2013; Schuck, Patricia Fernanda/O-1344-2013; da Costa
   Ferreira, Gustavo/B-6983-2014; De Oliveira, Marcos Roberto/D-7470-2015
OI Silva, Fatima Regina/0000-0002-1391-2354; Schuck, Patricia
   Fernanda/0000-0003-3148-4952; da Costa Ferreira,
   Gustavo/0000-0002-2892-8842; Klippel Ferreira,
   Bruna/0000-0002-3329-9972; De Oliveira, Marcos
   Roberto/0000-0003-2414-6605
FU Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq);
   Universidade do Extremo Sul Catarinense (UNESC); Nucleo de Excelencia em
   Neurociencias de Santa Catarina (NENASC Project/PRONEX)
FX This study was funded with grants from Conselho Nacional de
   Desenvolvimento Cientifico e Tecnologico (CNPq), Universidade do Extremo
   Sul Catarinense (UNESC) and Nucleo de Excelencia em Neurociencias de
   Santa Catarina (NENASC Project/PRONEX).
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NR 52
TC 5
Z9 5
U1 0
U2 12
PU ACAD BRASILEIRA DE CIENCIAS
PI RIO JANEIRO
PA RUA ANFILOFIO DE CARVALHO, 29, 3 ANDAR, 20030-060 RIO JANEIRO, BRAZIL
SN 0001-3765
EI 1678-2690
J9 AN ACAD BRAS CIENC
JI An. Acad. Bras. Cienc.
PD AUG
PY 2015
VL 87
IS 2
SU S
BP 1451
EP 1459
DI 10.1590/0001-3765201520140720
PG 9
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA CS1PU
UT WOS:000361840300015
PM 26312423
OA gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Dorrance, AM
   Matin, N
   Pires, PW
AF Dorrance, Anne M.
   Matin, Nusrat
   Pires, Paulo W.
TI The Effects of Obesity on the Cerebral Vasculature
SO CURRENT VASCULAR PHARMACOLOGY
LA English
DT Article
DE Obesity; insulin resistance; cerebral ischemia; dementia
ID BODY-MASS INDEX; NITRIC-OXIDE SYNTHASE; PERIVASCULAR ADIPOSE-TISSUE;
   INSULIN-RESISTANT RATS; DIET-INDUCED OBESITY; ISCHEMIC-STROKE;
   BLOOD-FLOW; METABOLIC SYNDROME; RISK-FACTORS; ZUCKER RAT
AB The incidence of obesity in the population is increasing at an alarming rate, with this comes an increased risk of insulin resistance (IR). Obesity and IR increase an individual's risk of having a stroke and they have been linked to several forms of dementia. Stroke and dementia are associated with, or exacerbated by, reduced cerebral blood flow, which has recently been described in obese patients. In this review we will discuss the effects of obesity on cerebral artery function and structure. Regarding their function, we will focus on the endothelium and nitric oxide (NO) dependent dilation. NO dependent dilation is impaired in cerebral arteries from obese rats, and the majority of evidence suggests this is a result of increased oxidative stress. We will also describe the limited studies showing that inward cerebral artery remodeling occurs in models of obesity, and that the remodeling is associated with an increase in the damage caused by cerebral ischemia. We will also discuss some of the more paradoxical findings associated with stroke and obesity, including the evidence that obesity is a positive factor for stroke survival. Finally we will discuss the evidence that links these changes in vascular structure and function to cognitive decline and dementia.
C1 [Dorrance, Anne M.; Matin, Nusrat; Pires, Paulo W.] Michigan State Univ, Dept Pharmacol & Toxicol, E Lansing, MI 48824 USA.
C3 Michigan State University
RP Dorrance, AM (corresponding author), Michigan State Univ, Dept Pharmacol & Toxicol, 1355 Bogue St, E Lansing, MI 48824 USA.
EM dorranc3@msu.edu
RI Pires, Paulo/I-8542-2014
OI Pires, Paulo/0000-0001-5972-4554; Dorrance, Anne/0000-0001-6573-2729
FU American Heart Association; AHA; AHA Established Investigator Award
   [0840122N]
FX This study was funded by the American Heart Association, PWP is a
   recipient of an AHA pre-doctoral fellowship and AMD has received an AHA
   Established Investigator Award (0840122N). The authors thank Daniel
   Bollman for producing the image of the brain and cerebral arteries in
   (Fig. 1).
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NR 133
TC 70
Z9 78
U1 1
U2 16
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1570-1611
EI 1875-6212
J9 CURR VASC PHARMACOL
JI Current Vascular Pharmacology
PY 2014
VL 12
IS 3
BP 462
EP 472
DI 10.2174/1570161112666140423222411
PG 11
WC Pharmacology & Pharmacy; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Cardiovascular System & Cardiology
GA AW4UI
UT WOS:000346275400013
PM 24846235
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Baek, EY
   Lee, SM
   Lee, JE
   Park, E
   Kim, Y
   Jung, IK
   Kim, JH
AF Baek, Eun Young
   Lee, Seung Min
   Lee, Jung Eun
   Park, Eunkyo
   Kim, Yuri
   Jung, In-Kyung
   Kim, Jung-Hyun
TI Effect of Rubus coreanus Miguel on prostate tumour growth
SO JOURNAL OF FUNCTIONAL FOODS
LA English
DT Article
DE Rubus coreanus Miquel; Prostate tumour; Antioxidants; Cell
   proliferation; Apoptosis; Polyphenols
ID CANCER-CELL PROLIFERATION; ANTIOXIDANT ACTIVITY; BLACK-RASPBERRY;
   IN-VITRO; DEGENERATIVE DISEASES; LIPID-PEROXIDATION; METABOLIC SYNDROME;
   OXIDATIVE STRESS; APOPTOSIS; RATS
AB The rapidly increasing incidence of prostate cancer in Korea has increased awareness of preventive measures, such as dietary supplementation. Unripe Rubus coreanus Miguel (RCM) has been used to improve prostate health. Using nude mice transplanted with a prostate cancer cell line, we investigated whether RCM supplementation was beneficial for inhibiting the formation or growth of prostate tumour, and its mechanisms. RCM effectively restricted tumour growth compared to the control but had no effect on tumour initiation. Ripe and unripe RCM exerted significant reduction in tumour growth compared to the control. The reduction in tumour mass shown in the RCM groups was associated with increased active form of caspase-3, indicating an enhanced caspase-3-mediated apoptotic process. In addition, RCM demonstrated a strong antioxidant capacity through a decrease in lipid peroxidation products. In addition, RCM modulated the activity of endogenous antioxidant enzymes through modest changes. Collectively, our data indicate that RCM is a promising alternative supplementation for limiting the growth of prostate cancer, and its effect is likely to be achieved through the initiation of caspase-3-mediated apoptosis. The antioxidant properties of RCM appear to play an essential role in its anti-proliferative effect on prostate tumours. (C) 2013 Elsevier Ltd. All rights reserved.
C1 [Baek, Eun Young; Lee, Jung Eun; Park, Eunkyo; Jung, In-Kyung; Kim, Jung-Hyun] Chung Ang Univ, Dept Home Econ Educ, Seoul 156756, South Korea.
   [Lee, Seung Min] Yonsei Univ, Coll Human Ecol, Brain Korea Project 21, Dept Food & Nutr, Seoul 120749, South Korea.
   [Kim, Yuri] Ewha Womans Univ, Dept Nutr Sci & Food Management, Seoul 120750, South Korea.
C3 Chung Ang University; Yonsei University; Ewha Womans University
RP Kim, JH (corresponding author), Chung Ang Univ, Dept Home Econ Educ, Seoul 156756, South Korea.
EM jjhkim@cau.ac.kr
RI Park, Eunkyo/AFW-5411-2022; Lee, Jung-Seok/L-6826-2019; Gim,
   Yuri/JNZ-3445-2023
OI Park, Eunkyo/0000-0002-4023-7198
FU National Research Foundation of Korea (NRF); Ministry of Education,
   Science and Technology [2009-0068227]
FX This research was supported by Basic Science Research Program through
   the National Research Foundation of Korea (NRF) funded by the Ministry
   of Education, Science and Technology (grant number is 2009-0068227).
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NR 38
TC 9
Z9 10
U1 0
U2 12
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1756-4646
J9 J FUNCT FOODS
JI J. Funct. Food.
PD JUL
PY 2013
VL 5
IS 3
BP 1478
EP 1486
DI 10.1016/j.jff.2013.06.005
PG 9
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA 195GZ
UT WOS:000322691600050
DA 2025-06-11
ER

PT J
AU Totani, N
   Tateishi, S
   Takimoto, T
   Shinohara, R
   Sasaki, H
AF Totani, Nagao
   Tateishi, Sayuri
   Takimoto, Tatsuya
   Shinohara, Risa
   Sasaki, Hideaki
TI Ferulic Acid Esters and Weight-Loss Promoting Effects in Rats
SO JOURNAL OF OLEO SCIENCE
LA English
DT Article
DE ferulic acid ester; oleoyl glycerol; weight loss; metabolic syndrome;
   phenolic acid
ID GALLIC ACID; OXIDATIVE STRESS; RICE BRAN; ORYZANOL; MICE; FRACTION
AB We previously fed rats with an ester (90 ppm in a powdered AIN93G diet) synthesized from gallic acid and 1,2-dioleoyl glycerol and found that it promoted weight loss more effectively than either octyl gallate or gallic acid. Here, we esterified ferulic acid (FerA) with oleic acid, monooleoyl glycerol and dioleoyl glycerol to obtain oleoyl ferulic acid (FO), feruloyl monooleoyl glycerol (FMO) and feruloyl dioleoyl glycerol (FDO) esters, respectively. A mixture of AIN93G and 90 ppm of each ester and FerA was fed to 10-week-old male Wistar rats for 12 weeks. The FMO and FDO groups weighed less than the control group starting from approximately 16 weeks of age. At 21 and 22 weeks of age, weight significantly differed between the FMO and both groups, respectively, and controls. The FO, FerA and control groups did not significantly differ in terms of body, liver, kidney and retroperitoneal fat tissue weights and serum biochemical findings. We concluded that the hydroxyl group of FerA is essential for promoting weight loss and that the carboxyl group should be esterified with alcohol. In addition, monooleoyl glycerol and dioleoyl glycerol did not show any difference as the alcohol moiety of the ester in the weight loss effect.
C1 [Totani, Nagao; Tateishi, Sayuri] Kobe Gakuin Univ, Fac Nutr, Nishi Ku, Kobe, Hyogo 6512180, Japan.
   [Takimoto, Tatsuya; Shinohara, Risa; Sasaki, Hideaki] Kobe Gakuin Univ, Fac Pharmaceut Sci, Chuo Ku, Kobe, Hyogo 6508586, Japan.
C3 Kobe Gakuin University; Kobe Gakuin University
RP Totani, N (corresponding author), Kobe Gakuin Univ, Fac Nutr, Nishi Ku, 518 Arise,Ikawadani Cho, Kobe, Hyogo 6512180, Japan.
EM totani@nutr.kobegakuin.ac.jp
OI Takimoto, Tatsuya/0000-0003-3620-1608; Sasaki,
   Hideaki/0000-0003-0777-057X
FU Life Science Center of Kobe-Gakuin University
FX This work was supported partly by grants from the Life Science Center of
   Kobe-Gakuin University.
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NR 11
TC 9
Z9 12
U1 0
U2 9
PU JAPAN OIL CHEMISTS SOC
PI TOKYO
PA YUSHI KOGYO KAIKAN BLDG, 13-11, NIHONBASHI 3-CHOME, CHUO-KU, TOKYO,
   103-0027, JAPAN
SN 1345-8957
EI 1347-3352
J9 J OLEO SCI
JI J. Oleo Sci.
PD JUN
PY 2012
VL 61
IS 6
BP 331
EP 336
DI 10.5650/jos.61.331
PG 6
WC Chemistry, Applied; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Food Science & Technology
GA 950EH
UT WOS:000304631900004
PM 22687778
OA Bronze
DA 2025-06-11
ER

PT J
AU Tolmay, CM
   Malan, L
   Van Rooyen, JM
AF Tolmay, Claire M.
   Malan, Leone
   Van Rooyen, Johannes M.
TI The relationship between cortisol, C-reactive protein and hypertension
   in African and Causcasian women: the POWIRS study
SO CARDIOVASCULAR JOURNAL OF AFRICA
LA English
DT Article
DE cortisol; C-reactive protein; hypertension; ethnic
ID CARDIOVASCULAR-DISEASE; ABDOMINAL ADIPOSITY; INSULIN-RESISTANCE;
   METABOLIC SYNDROME; BLOOD-PRESSURE; YOUNG-ADULTS; RISK; STRESS; OBESITY;
   ATHEROSCLEROSIS
AB Research on the roles that C-reactive protein (CRP) and other risk factors such as cortisol and obesity play in the diagnosis of cardiovascular disease (CVD) in African and Caucasian women has become increasingly imperative when one considers the prevalence of hypertension in these groups. CRP and cortisol have been associated with an increased prevalence of hypertension and obesity. Cortisol has also been linked with both hypertension and the hypothalamic-pituitary-adrenal (HPA) response. African women have previously presented with an increased vascular reactivity. Conversely, Caucasian women have displayed an increased central cardiac reactivity. We included African (n = 102) and Caucasian (n = 115) women in the study, matched for age and body mass index. Elevated CRP levels were observed in African women compared to Caucasian women. A trend of hypocortisolism was exhibited in both hypertensive ethnic groups. Systolic blood pressure (SBP) and a vascular marker, arterial compliance (Cw), predicted hypertension in African women. Conversely, in Caucasian women, only SBP predicted hypertension. These results suggest the apparently diverse roles that dysregulation by the HPA axis, in conjunction with the respective cardiac and vascular responses in both Caucasian and African women, can play in future cardiovascular risk for these groups.
C1 [Tolmay, Claire M.; Malan, Leone; Van Rooyen, Johannes M.] North West Univ, HART, Potchefstroom, South Africa.
C3 North West University - South Africa
RP Tolmay, CM (corresponding author), North West Univ, HART, Potchefstroom, South Africa.
EM leone.malan@nwu.ac.za
RI Malan, Leone/Q-8187-2019; Malan, Leone/D-7203-2014
OI Malan, Leone/0000-0003-3187-2410
FU National Research Foundation [GUN 2054068]; Medical Research Council;
   North-West University (Potchefstroom campus)
FX We thank the participants and all supporting staff that contributed to
   the POWIRS study. We are also grateful to the financial contributors to
   this project: the National Research Foundation (GUN 2054068), the
   Medical Research Council and the Research Focus Area 9.1 of the
   North-West University (Potchefstroom campus).
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NR 45
TC 12
Z9 14
U1 0
U2 3
PU CLINICS CARDIVE PUBL PTY LTD
PI DURBANVILLE
PA PO BOX 1013, DURBANVILLE, 7551, SOUTH AFRICA
SN 1995-1892
EI 1680-0745
J9 CARDIOVASC J AFR
JI Cardiovasc. J. Afr.
PD MAR
PY 2012
VL 23
IS 2
BP 78
EP 84
DI 10.5830/CVJA-2011-035
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 957HU
UT WOS:000305152500010
PM 22447476
OA Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Kaliman, P
   Párrizas, M
   Lalanza, JF
   Camins, A
   Escorihuela, RM
   Pallàs, M
AF Kaliman, Perla
   Parrizas, Marcelina
   Lalanza, Jaume F.
   Camins, Antoni
   Maria Escorihuela, Rosa
   Pallas, Merce
TI Neurophysiological and epigenetic effects of physical exercise on the
   aging process
SO AGEING RESEARCH REVIEWS
LA English
DT Review
DE Exercise; Brain; Aging; Behavior; Epigenetics
ID MESSENGER-RNA EXPRESSION; METABOLIC SYNDROME; GENE-EXPRESSION; AEROBIC
   EXERCISE; SKELETAL-MUSCLE; LIFE-SPAN; COGNITIVE DECLINE; TELOMERE
   LENGTH; CARDIOVASCULAR FITNESS; CALORIC RESTRICTION
AB Aging is a gradual process during which molecular and cellular processes deteriorate progressively, often leading to such pathological conditions as vascular and metabolic disorders and cognitive decline. Although the mechanisms of aging are not yet fully understood, inflammation, oxidative damage, mitochondrial dysfunction, functional alterations in specific neuronal circuits and a restricted degree of apoptosis are involved. Physical exercise improves the efficiency of the capillary system and increases the oxygen supply to the brain, thus enhancing metabolic activity and oxygen intake in neurons, and increases neurotrophin levels and resistance to stress. Regular exercise and an active lifestyle during adulthood have been associated with reduced risk and protective effects for mild cognitive impairment and Alzheimer's disease. Similarly, studies in animal models show that physical activity has positive physiological and cognitive effects that correlate with changes in transcriptional profiles. According to numerous studies, epigenetic events that include changes in DNA methylation patterns, histone modification and alterations in microRNA profiles seem to be a signature of aging. Hence, insight into the epigenetic mechanisms involved in the aging process and their modulation through lifestyle interventions such as physical exercise might open new avenues for the development of preventive and therapeutic strategies to treat aging-related diseases. (C) 2011 Elsevier B.V. All rights reserved.
C1 [Kaliman, Perla; Parrizas, Marcelina] IDIBAPS, E-08036 Barcelona, Spain.
   [Lalanza, Jaume F.] Univ Autonoma Barcelona, Fac Psicol, Dept Psicol Basica Evolut & Educ, Bellaterra, Spain.
   [Lalanza, Jaume F.; Maria Escorihuela, Rosa] Univ Autonoma Barcelona, Fac Med, Dept Psiquiatria & Med Legal, Inst Neurociencias, Bellaterra, Spain.
   [Camins, Antoni; Pallas, Merce] Univ Barcelona, Inst Biomed, Fac Farm, Unidad Farmacol & Farmacognosia, E-08007 Barcelona, Spain.
C3 University of Barcelona; Hospital Clinic de Barcelona; IDIBAPS;
   Autonomous University of Barcelona; Consejo Superior de Investigaciones
   Cientificas (CSIC); Universidad Miguel Hernandez de Elche; CSIC-UMH -
   Instituto de Neurociencias de Alicante (IN); Autonomous University of
   Barcelona; University of Barcelona
RP Kaliman, P (corresponding author), IDIBAPS, Villarroel 170, E-08036 Barcelona, Spain.
EM pkaliman@clinic.ub.es; rosamaria.escorihuela@uab.es; pallas@ub.edu
RI Parrizas, Marcelina/AAS-3629-2021; Camins, Antonio/J-5126-2019; Pallas,
   Merce/H-3129-2016; Lalanza, Jaume F./C-9186-2011; Escorihuela, Rosa
   M/L-4524-2014
OI Pallas, Merce/0000-0003-3095-4254; Lalanza, Jaume
   F./0000-0003-2481-2188; Camins, Antoni/0000-0002-1229-5956; Parrizas,
   Marcelina/0000-0003-1296-8302; Escorihuela, Rosa M/0000-0001-9368-5173
FU Spanish Ministry of Science and Innovation [DPS2008-06998-C02]; Fondo de
   Investigacion Sanitaria [PI080400]; Instituto de Salud Carlos III;
   Spanish Ministry of Science and Innovation (MICINN) [BFU2009-09988/BMC,
   SAF-2009-13093, SAF2010-15050]; Catalan Government (Generalitat de
   Catalunya) [2009/SGR00853]; Generalitat de Catalunya [FI-DGR 2011]
FX This study was has been supported by grant DPS2008-06998-C02 (MP and
   RME) Spanish Ministry of Science and Innovation, and by grants PI080400
   from the Fondo de Investigacion Sanitaria and the Instituto de Salud
   Carlos III (AC), BFU2009-09988/BMC (MP), SAF-2009-13093 (MP) and
   SAF2010-15050 (PK) from the Spanish Ministry of Science and Innovation
   (MICINN). We thank the Catalan Government (Generalitat de Catalunya) for
   supporting the research groups (2009/SGR00853) (AC). J.F.L. was
   supported by a predoctoral fellowship from the Generalitat de Catalunya
   (FI-DGR 2011).
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NR 135
TC 83
Z9 91
U1 1
U2 72
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 1568-1637
EI 1872-9649
J9 AGEING RES REV
JI Ageing Res. Rev.
PD SEP
PY 2011
VL 10
IS 4
BP 475
EP 486
DI 10.1016/j.arr.2011.05.002
PG 12
WC Cell Biology; Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Geriatrics & Gerontology
GA 827RT
UT WOS:000295446300010
PM 21624506
DA 2025-06-11
ER

PT J
AU Zielinska, AE
   Walker, EA
   Stewart, PM
   Lavery, GG
AF Zielinska, Agnieszka E.
   Walker, Elizabeth A.
   Stewart, Paul M.
   Lavery, Gareth G.
TI Biochemistry and physiology of hexose-6-phosphate knockout mice
SO MOLECULAR AND CELLULAR ENDOCRINOLOGY
LA English
DT Article; Proceedings Paper
CT 14th Biennial Adrenal Cortex Conference (Adrenal 2010)
CY JUN 16-18, 2010
CL San Diego, CA
DE Endoplasmic reticulum; Glucocorticoid; Knockout mice; Metabolism; Muscle
ID 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1; CORTISONE REDUCTASE
   DEFICIENCY; PITUITARY-ADRENAL AXIS; PENTOSE-PHOSPHATE PATHWAY; UNFOLDED
   PROTEIN RESPONSE; ADIPOSE STROMAL CELLS; ENDOPLASMIC-RETICULUM;
   SKELETAL-MUSCLE; METABOLIC SYNDROME; VISCERAL OBESITY
AB Hexose-6-phosphate dehydrogenase (H6PDH) has emerged as an important factor in setting the redox status of the endoplasmic reticulum (ER) lumen. An important role of H6PDH is to generate a high NADPH/NADP(+) ratio which permits 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1) to act as an oxo-reductase, catalyzing the activation of glucocorticoids (GCs). In H6PDH knockout mice 11 beta-HSD1 assumes dehydrogenase activity and inactivates GCs, rendering the target cell relatively GC insensitive. Consequently, H6PDHKO mice have a phenotype consistent with defects in the permissive and adaptive actions of GCs upon physiology. H6PDHKO mice have also offered an insight into muscle physiology as they also present with a severe vacuolating myopathy, abnormalities of glucose homeostasis and activation of the unfolded protein response due to ER stress, and a number of mechanisms driving this phenotype are thought to be involved. This article will review what we understand of the redox control of GC hormone metabolism regulated by H6PDH, and how H6PDHKO mice have allowed an in-depth understanding of its potentially novel, GC-independent roles in muscle physiology. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
C1 [Zielinska, Agnieszka E.; Walker, Elizabeth A.; Stewart, Paul M.; Lavery, Gareth G.] Univ Birmingham, Sch Clin & Expt Med, Ctr Endocrinol Diabet & Metab, Birmingham B15 2TT, W Midlands, England.
C3 University of Birmingham
RP Lavery, GG (corresponding author), Univ Birmingham, Sch Clin & Expt Med, Ctr Endocrinol Diabet & Metab, Birmingham B15 2TT, W Midlands, England.
EM g.g.lavery@bham.ac.uk
RI Lavery, Gareth/F-9346-2010
FU BBSRC [BB/G023468/1] Funding Source: UKRI; Biotechnology and Biological
   Sciences Research Council [BB/G023468/1] Funding Source: Medline; NIDDK
   NIH HHS [DK068101, DK54480] Funding Source: Medline; Wellcome Trust
   [066357] Funding Source: Medline
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NR 54
TC 15
Z9 17
U1 0
U2 2
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0303-7207
J9 MOL CELL ENDOCRINOL
JI Mol. Cell. Endocrinol.
PD APR 10
PY 2011
VL 336
IS 1-2
SI SI
BP 213
EP 218
DI 10.1016/j.mce.2010.12.004
PG 6
WC Cell Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Cell Biology; Endocrinology & Metabolism
GA 748HN
UT WOS:000289381400032
PM 21146583
DA 2025-06-11
ER

PT J
AU Wiernsperger, N
   Rapin, J
AF Wiernsperger, Nicolas
   Rapin, JeanRobert
TI Trace elements in glucometabolic disorders: an update
SO DIABETOLOGY & METABOLIC SYNDROME
LA English
DT Review
ID DEPENDENT DIABETES-MELLITUS; CHROMIUM PICOLINATE SUPPLEMENTATION;
   IMPROVES INSULIN SENSITIVITY; MAMMALIAN ZINC TRANSPORTERS; IMPAIRED
   GLUCOSE-TOLERANCE; HEALTHY-YOUNG ADULTS; METABOLIC SYNDROME; OXIDATIVE
   STRESS; VANADYL SULFATE; IN-VIVO
AB Many trace elements, among which metals, are indispensable for proper functioning of a myriad of biochemical reactions, more particularly as enzyme cofactors. This is particularly true for the vast set of processes involved in regulation of glucose homeostasis, being it in glucose metabolism itself or in hormonal control, especially insulin. The role and importance of trace elements such as chromium, zinc, selenium, lithium and vanadium are much less evident and subjected to chronic debate. This review updates our actual knowledge concerning these five trace elements. A careful survey of the literature shows that while theoretical postulates from some key roles of these elements had led to real hopes for therapy of insulin resistance and diabetes, the limited experience based on available data indicates that beneficial effects and use of most of them are subjected to caution, given the narrow window between safe and unsafe doses. Clear therapeutic benefit in these pathologies is presently doubtful but some data indicate that these metals may have a clinical interest in patients presenting deficiencies in individual metal levels. The same holds true for an association of some trace elements such as chromium or zinc with oral antidiabetics. However, this area is essentially unexplored in adequate clinical trials, which are worth being performed.
C1 [Wiernsperger, Nicolas] Inst Natl Sci Appl, INSERM, U870, F-69621 Villeurbanne, France.
   [Rapin, JeanRobert] Univ Bourgogne, Fac Med Pharm, F-21000 Dijon, France.
C3 Institut National de la Sante et de la Recherche Medicale (Inserm);
   Institut National des Sciences Appliquees de Lyon - INSA Lyon;
   Universite Bourgogne Europe
RP Wiernsperger, N (corresponding author), Inst Natl Sci Appl, INSERM, U870, 6 Bld J Capelle, F-69621 Villeurbanne, France.
EM nicolas.wiernsperger@free.fr
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NR 175
TC 116
Z9 129
U1 0
U2 19
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1758-5996
J9 DIABETOL METAB SYNDR
JI Diabetol. Metab. Syndr.
PD DEC 19
PY 2010
VL 2
AR 70
DI 10.1186/1758-5996-2-70
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 759RB
UT WOS:000290264900001
PM 21167072
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Perdaens, O
   van Pesch, V
AF Perdaens, Oceane
   van Pesch, Vincent
TI Should We Consider Neurodegeneration by Itself or in a Triangulation
   with Neuroinflammation and Demyelination? The Example of Multiple
   Sclerosis and Beyond
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE neurodegeneration; neuroinflammation; demyelination; multiple sclerosis;
   Alzheimer's disease; Parkinson's disease; metabolic syndrome
ID BLOOD-BRAIN-BARRIER; CENTRAL-NERVOUS-SYSTEM; MYELIN BASIC-PROTEIN;
   HIGH-FAT DIET; WHITE-MATTER HYPERINTENSITIES; NORMAL-APPEARING WHITE;
   BODY-MASS INDEX; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; CD8(+)
   T-CELLS; MITOCHONDRIAL PERMEABILITY TRANSITION
AB Neurodegeneration is preeminent in many neurological diseases, and still a major burden we fail to manage in patient's care. Its pathogenesis is complicated, intricate, and far from being completely understood. Taking multiple sclerosis as an example, we propose that neurodegeneration is neither a cause nor a consequence by itself. Mitochondrial dysfunction, leading to energy deficiency and ion imbalance, plays a key role in neurodegeneration, and is partly caused by the oxidative stress generated by microglia and astrocytes. Nodal and paranodal disruption, with or without myelin alteration, is further involved. Myelin loss exposes the axons directly to the inflammatory and oxidative environment. Moreover, oligodendrocytes provide a singular metabolic and trophic support to axons, but do not emerge unscathed from the pathological events, by primary myelin defects and cell apoptosis or secondary to neuroinflammation or axonal damage. Hereby, trophic failure might be an overlooked contributor to neurodegeneration. Thus, a complex interplay between neuroinflammation, demyelination, and neurodegeneration, wherein each is primarily and secondarily involved, might offer a more comprehensive understanding of the pathogenesis and help establishing novel therapeutic strategies for many neurological diseases and beyond.
C1 [Perdaens, Oceane; van Pesch, Vincent] Univ Catholique Louvain UCLouvain, Inst Neurosci, Neurochem Grp, B-1200 Brussels, Belgium.
   [van Pesch, Vincent] Univ Catholique Louvain UCLouvain, Dept Neurol, Clin Univ St Luc, B-1200 Brussels, Belgium.
C3 Universite Catholique Louvain; Cliniques Universitaires Saint-Luc
RP van Pesch, V (corresponding author), Univ Catholique Louvain UCLouvain, Inst Neurosci, Neurochem Grp, B-1200 Brussels, Belgium.; van Pesch, V (corresponding author), Univ Catholique Louvain UCLouvain, Dept Neurol, Clin Univ St Luc, B-1200 Brussels, Belgium.
EM oceane.perdaens@uclouvain.be; vincent.vanpesch@saintluc.uclouvain.be
RI van Pesch, Vincent/AAK-9506-2020
OI Perdaens, Oceane/0000-0002-5534-4463; van Pesch,
   Vincent/0000-0003-2885-9004
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NR 846
TC 1
Z9 1
U1 6
U2 6
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD DEC
PY 2024
VL 25
IS 23
AR 12637
DI 10.3390/ijms252312637
PG 68
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA P2T5E
UT WOS:001376498700001
PM 39684351
OA gold
DA 2025-06-11
ER

PT J
AU Duan, LY
   An, XD
   Zhang, YH
   Jin, D
   Zhao, SH
   Zhou, RR
   Duan, YY
   Zhang, YQ
   Liu, XM
   Lian, FM
AF Duan, Liyun
   An, Xuedong
   Zhang, Yuehong
   Jin, De
   Zhao, Shenghui
   Zhou, Rongrong
   Duan, Yingying
   Zhang, Yuqing
   Liu, Xinmin
   Lian, Fengmei
TI Gut microbiota as the critical correlation of polycystic ovary syndrome
   and type 2 diabetes mellitus
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Article
DE Gut microbiota; Polycystic ovary syndrome; Type 2 diabetes mellitus;
   Simultaneous treatment
ID CHAIN AMINO-ACIDS; INSULIN-RESISTANCE; BILE-ACIDS; METABOLIC SYNDROME;
   BARIATRIC SURGERY; OXIDATIVE STRESS; GASTRIC BYPASS; CROSS-TALK; BRAIN
   AXIS; OBESITY
AB Gut microbiota forms a symbiotic relationship with the host and maintains the ecological balance of the internal and external environment of the human body. However, dysbiosis of the gut microbiota and immune deficiency, as well as environmental changes, can destroy the host-microbial balance, leading to the occurrence of a variety of diseases, such as polycystic ovary syndrome (PCOS), type 2 diabetes mellitus (T2DM), and obesity. Meanwhile, diseases can also affect gut microbiota, forming a vicious cycle. The role of the intestinal microbiota in different diseases have been proven by several studies; however, as a common target of PCOS and T2DM, there are few reports on the treatment of different diseases through the regulation of intestinal microbiota as the critical correlation. This review analyzed the common mechanisms of intestinal microbiota in PCOS and T2DM, including the dysbiosis of gut microbiota, endotoxemia, short-chain fatty acids, biotransformation of bile acids, and synthesis of amino acid in regulating insulin resistance, obesity, chronic inflammation, and mitochondrial dysfunction. The possible therapeutic effects of probiotics and/or prebiotics, fecal microbiota transplantation, bariatric surgery, dietary intervention, drug treatment, and other treatments targeted at regulating intestinal microbiota were also elucidated.
C1 [Duan, Liyun; An, Xuedong; Zhang, Yuehong; Jin, De; Zhao, Shenghui; Zhou, Rongrong; Duan, Yingying; Zhang, Yuqing; Liu, Xinmin; Lian, Fengmei] China Acad Chinese Med Sci, Guanganmen Hosp, Dept Endocrinol, Beijing 100053, Peoples R China.
   [Duan, Liyun; An, Xuedong; Zhang, Yuehong; Jin, De; Zhou, Rongrong; Zhang, Yuqing] China Acad Chinese Med Sci, Beijing 100700, Peoples R China.
   [Zhao, Shenghui; Duan, Yingying] Beijing Univ Chinese Med, Beijing 100029, Peoples R China.
C3 Guang'anmen Hospital, CACMS; China Academy of Chinese Medical Sciences;
   China Academy of Chinese Medical Sciences; Beijing University of Chinese
   Medicine
RP Liu, XM; Lian, FM (corresponding author), China Acad Chinese Med Sci, Guanganmen Hosp, Dept Endocrinol, Beijing 100053, Peoples R China.
EM beijingliuxm@163.com; Lfm565@sohu.com
RI Duan, Yingying/J-6128-2017
OI an, Xuedong/0000-0002-2787-1645
FU National Public Welfare Industry Special [201507001-11]; National
   Traditional Chinese Medicine Administration of Traditional Chinese
   Medicine Science and Technology Research Project [2016ZX03]
FX This work was supported by the National Public Welfare Industry Special
   (201507001-11) and the National Traditional Chinese Medicine
   Administration of Traditional Chinese Medicine Science and Technology
   Research Project (2016ZX03) . The funders had no role in the study
   design, interpretation, or writing of the manuscript.
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NR 170
TC 23
Z9 24
U1 4
U2 52
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD OCT
PY 2021
VL 142
AR 112094
DI 10.1016/j.biopha.2021.112094
EA AUG 2021
PG 11
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA UR7PS
UT WOS:000696937100003
PM 34449321
OA gold
DA 2025-06-11
ER

PT J
AU Aaseth, J
   Alexander, J
   Alehagen, U
AF Aaseth, Jan
   Alexander, Jan
   Alehagen, Urban
TI Coenzyme Q10 supplementation - In ageing and disease
SO MECHANISMS OF AGEING AND DEVELOPMENT
LA English
DT Article
DE Coenzyme Q(10); Physiological function; Ageing; Cardiovascular disease;
   Neurodegenerative disease
ID IMPROVES ENDOTHELIAL DYSFUNCTION; PARKINSONS-DISEASE; DOUBLE-BLIND;
   MITOCHONDRIAL DYSFUNCTION; THIOREDOXIN REDUCTASE; OXIDATIVE STRESS;
   ALPHA-TOCOPHEROL; Q BIOSYNTHESIS; DEFICIENCY; PLASMA
AB Coenzyme Q(10) (CoQ(10)) is an essential component of the mitochondrial electron transport chain. It is also an antioxidant in cellular membranes and lipoproteins. All cells produce CoQ(10) by a specialized cytoplasmatic-mitochondrial pathway. CoQ(10) deficiency can result from genetic failure or ageing. Some drugs including statins, widely used by inter alia elderly, may inhibit endogenous CoQ(10) synthesis. There are also chronic diseases with lower levels of CoQ(10) in tissues and organs. High doses of CoQ(10) may increase both circulating and intracellular levels, but there are conflicting results regarding bioavailability. Here, we review the current knowledge of CoQ(10) biosynthesis and primary and acquired CoQ(10) deficiency, and results from clinical trials based on CoQ(10) supplementation. There are indications that supplementation positively affects mitochondrial deficiency syndrome and some of the symptoms of ageing. Cardiovascular disease and inflammation appear to be alleviated by the antioxidant effect of CoQ(10). There is a need for further studies and well-designed clinical trials, with CoQ(10) in a formulation of proven bioavailability, involving a greater number of participants undergoing longer treatments in order to assess the benefits of CoQ(10) treatment in neurodegenerative disorders, as well as in metabolic syndrome and its complications.
C1 [Aaseth, Jan] Innlandet Hosp Trust, Res Dept, POB 104, N-2381 Brumunddal, Norway.
   [Alexander, Jan] Norwegian Inst Publ Hlth, POB 222 Skoyen, N-0213 Oslo, Norway.
   [Alehagen, Urban] Linkoping Univ, Dept Med & Hlth Sci, Div Cardiovasc Med, SE-58185 Linkoping, Sweden.
C3 Innlandet Hospital Trust; Norwegian Institute of Public Health (NIPH);
   Linkoping University
RP Alexander, J (corresponding author), Norwegian Inst Publ Hlth, POB 222 Skoyen, N-0213 Oslo, Norway.
EM jan.alexander@fhi.no
RI Aaseth, Jan/J-6764-2017
FU Norwegian Institute of Public Health, Norway; Innlandet Hospital Trust,
   Norway
FX Norwegian Institute of Public Health, Norway, is acknowledged for
   support. Innlandet Hospital Trust, Norway, is acknowledged for support.
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NR 88
TC 48
Z9 50
U1 1
U2 10
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0047-6374
EI 1872-6216
J9 MECH AGEING DEV
JI Mech. Ageing Dev.
PD JUL
PY 2021
VL 197
AR 111521
DI 10.1016/j.mad.2021.111521
EA JUN 2021
PG 7
WC Cell Biology; Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Geriatrics & Gerontology
GA TC3BJ
UT WOS:000668514900002
PM 34129891
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Khajeniazi, S
   Shakeri, R
   Marjani, A
AF Khajeniazi, Safoura
   Shakeri, Raheleh
   Marjani, Abdoljalal
TI Evaluation of Relationship Between Arylesterase-Based Activity and
   Genetic Variants of Paraoxonase1 in T2DM Patients within Golestan
   Province
SO INDIAN JOURNAL OF CLINICAL BIOCHEMISTRY
LA English
DT Article
DE Type2 diabetes; Promoter polymorphism; Arylesterase; Genotype; PCR-RFLP
ID TYPE-2 DIABETES-MELLITUS; SERUM PARAOXONASE; METABOLIC SYNDROME;
   OXIDATIVE STRESS; POLYMORPHISMS; ENZYME; PARAOXONASE/ARYLESTERASE;
   CHILDREN; OBESITY
AB Arylesterase activity of Paraoxonase-1 (PON1) enzyme may be play important role in initiation and progression of several diseases. Activity or serum level of Arylesterase can be affected by many genetic alterations such as SNPs. The reduction in the activity and serum level of Arylesterase could be involved in Type2 diabetes mellitus (T2DM). The aim of this investigation is to examine the association between Arylesterase activity and promoter polymorphism (- 108C > T) of PON1gene in patients with T2DM in Golestan Province, northern area of Iran. Achievement of this purpose was due to DNA obtaining from blood then SNP determination using PCR-RFLP and Arylesterase activity measurement in the serum of 90 normal individuals and 90patients suffering diabetes. Data was processed by SPSS software version 16. The significant association was observed between the Arylesterase activity and three genotypes of PON1 gene such as CC, CT, and TT in subjects with T2DM. In the present study, it has been shown level of Arylestrase activity of PON1 in patients (117.33 +/- 63.96) is lower than it in control group (289.33 +/- 68.38); P < 0.05. Our results declared that activity of Arylesterase in diabetic patients was significantly lower than the healthy individuals.
C1 [Khajeniazi, Safoura] Golestan Univ Med Sci, Stem Cell Res Ctr, Gorgan, Golestan, Iran.
   [Shakeri, Raheleh; Marjani, Abdoljalal] Golestan Univ Med Sci, Metab Disorders Res Ctr, Dept Biochem & Biophys, Gorgan, Golestan, Iran.
C3 Golestan University of Medical Sciences; Golestan University of Medical
   Sciences
RP Khajeniazi, S (corresponding author), Golestan Univ Med Sci, Stem Cell Res Ctr, Gorgan, Golestan, Iran.
EM niazie80@gmail.com
RI Marjani, Abdol/P-8976-2017
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PU SPRINGER INDIA
PI NEW DELHI
PA 7TH FLOOR, VIJAYA BUILDING, 17, BARAKHAMBA ROAD, NEW DELHI, 110 001,
   INDIA
SN 0970-1915
EI 0974-0422
J9 INDIAN J CLIN BIOCHE
JI Indian J. Clin. Biochem.
PD APR
PY 2020
VL 35
IS 2
BP 239
EP 244
DI 10.1007/s12291-019-00822-3
PG 6
WC Biochemistry & Molecular Biology
WE Emerging Sources Citation Index (ESCI)
SC Biochemistry & Molecular Biology
GA LC7WO
UT WOS:000525544100014
PM 32226257
OA Green Published
DA 2025-06-11
ER

PT J
AU Bobe, G
   Zhang, ZZ
   Kopp, R
   Garzotto, M
   Shannon, J
   Takata, Y
AF Bobe, Gerd
   Zhang, Zhenzhen
   Kopp, Ryan
   Garzotto, Mark
   Shannon, Jackilen
   Takata, Yumie
TI Phytol and its metabolites phytanic and pristanic acids for risk of
   cancer: current evidence and future directions
SO EUROPEAN JOURNAL OF CANCER PREVENTION
LA English
DT Review
DE cancer; phytanic acid; phytanic acid; phytol
ID METHYLACYL-COA RACEMASE; CHAIN FATTY-ACID; ALPHA PPAR-ALPHA;
   REFSUMS-DISEASE; OXIDATIVE STRESS; CELL-DEATH; ACTIVATION; MITOCHONDRIA;
   MARKER; EXPRESSION
AB This review summarizes the current evidence on the potential role of phytol, a microbial metabolite of chlorophyl A, and its metabolites, phytanic and pristanic acids, in carcinogenesis. Primary food sources in Western diets are the nut skin for phytol and lipids in dairy, beef and fish for its metabolites. Phytol and its metabolites gained interest as dietary compounds for cancer prevention because, as natural ligands of peroxisome proliferator-activated receptor-alpha and -gamma and retinoid X receptor, phytol and its metabolites have provided some evidence in cell culture studies and limited evidence in animal models of anti-carcinogenic, anti-inflammatory and anti-metabolic-syndrome properties at physiological concentrations. However, there may be a narrow range of efficacy, because phytol and its metabolites at supra-physiological concentrations can cause in vitro cytotoxicity in non-cancer cells and can cause morbidity and mortality in animal models. In human studies, evidence for a role of phytol and its metabolites in cancer prevention is currently limited and inconclusive. In short, phytol and its metabolites are potential dietary compounds for cancer prevention, assuming the challenges in preventing cytotoxicity in non-cancer cells and animal models and understanding phytol metabolism can be mitigated.
C1 [Bobe, Gerd] Oregon State Univ, Linus Pauling Inst, Corvallis, OR 97331 USA.
   [Bobe, Gerd] Oregon State Univ, Coll Agr Sci, Dept Anim & Rangeland Sci, Corvallis, OR 97331 USA.
   [Zhang, Zhenzhen] Oregon Hlth & Sci Univ, Knight Canc Inst, Div Hematol Oncol, Portland, OR 97201 USA.
   [Kopp, Ryan; Garzotto, Mark] Oregon Hlth & Sci Univ, Portland Vet Affairs Med Ctr, Dept Urol, Portland, OR 97201 USA.
   [Kopp, Ryan; Garzotto, Mark] Oregon Hlth & Sci Univ, Dept Urol, Portland, OR 97201 USA.
   [Shannon, Jackilen] Oregon Hlth & Sci Univ, OHSU PSU Sch Publ Hlth, Portland, OR 97201 USA.
   [Takata, Yumie] Oregon State Univ, Sch Biol & Populat Hlth Sci, Coll Publ Hlth & Human Sci, Corvallis, OR 97331 USA.
C3 Oregon State University; Oregon State University; Oregon Health &
   Science University; Oregon Health & Science University; US Department of
   Veterans Affairs; Veterans Health Administration (VHA); VA Portland
   Health Care System; Portland VA Medical Center; Oregon Health & Science
   University; Oregon Health & Science University; Oregon State University
RP Takata, Y (corresponding author), Oregon State Univ, Coll Publ Hlth & Human Sci, 103 Milam Hall, Corvallis, OR 97331 USA.
EM yumie.takata@oregonstate.edu
OI Zhang, Zhenzhen/0000-0002-9440-3892; Kopp, Ryan/0000-0003-3478-8564
FU Knight Cancer Institute OHSU/OSU Cancer Prevention and Control
   Initiative [PHR030-PV07]
FX This study was supported by the Knight Cancer Institute OHSU/OSU Cancer
   Prevention and Control Initiative (PHR030-PV07 to Y.T.). The funders had
   no role in the submission of the manuscript. We thank Ms. Alexandra
   Heisler and Dr. Jessica Keune for their assistance in editing the
   manuscript.
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NR 76
TC 25
Z9 28
U1 8
U2 27
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0959-8278
EI 1473-5709
J9 EUR J CANCER PREV
JI Eur. J. Cancer Prev.
PD MAR
PY 2020
VL 29
IS 2
BP 191
EP 200
DI 10.1097/CEJ.0000000000000534
PG 10
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA LG3QT
UT WOS:000528020200014
PM 31436750
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Sureda, A
   Martorell, M
   Bibiloni, MD
   Bouzas, C
   Gallardo-Alfaro, L
   Mateos, D
   Capó, X
   Tur, JA
   Pons, A
AF Sureda, Antoni
   Martorell, Miquel
   Bibiloni, Maria del Mar
   Bouzas, Cristina
   Gallardo-Alfaro, Laura
   Mateos, David
   Capo, Xavier
   Tur, Josep A.
   Pons, Antoni
TI Effect of Free Fatty Acids on Inflammatory Gene Expression and Hydrogen
   Peroxide Production by Ex Vivo Blood Mononuclear Cells
SO NUTRIENTS
LA English
DT Article
DE PBMC; fatty acids; LPS; gene expression; ROS production
ID TOLL-LIKE RECEPTORS; DIET SUPPLEMENTATION; KAPPA-B; OXIDATIVE STRESS;
   PROFILES; ACTIVATION; EXERCISE; PLASMA; TRANSCRIPTOME; BIOMARKERS
AB The aim of this study was to assess free fatty acids' (FAs) ex vivo anti-/proinflammatory capabilities and their influence on inflammatory gene expression and H2O2 production by human peripheral blood mononuclear cells (PBMCs). Anthropometric and clinical measurements were performed in 26 participants with metabolic syndrome. Isolated PBMCs were incubated ex vivo for 2 h with several free fatty acids-palmitic, oleic, alpha-linolenic, gamma-linolenic, arachidonic and docosahexaenoic at 50 mu M, and lipopolysaccharide (LPS) alone or in combination. H2O2 production and IL6, NF kappa B, TLR2, TNF alpha, and COX-2 gene expressions were determined. Palmitic, gamma-linolenic, and arachidonic acids showed minor effects on inflammatory gene expression, whereas oleic, alpha-linolenic, and docosahexaenoic acids reduced proinflammatory gene expression in LPS-stimulated PBMCs. Arachidonic and alpha-linolenic acids treatment enhanced LPS-stimulated H2O2 production by PBMCs, while palmitic, oleic, gamma-linolenic, and docosahexaenoic acids did not exert significant effects. Oleic, alpha-linolenic, and docosahexaenoic acids induced anti-inflammatory responses in PBMCs. Arachidonic and alpha-linolenic acids enhanced the oxidative status of LPS-stimulated PBMCs. In conclusion, PBMC ex vivo assays are useful to assess the anti-/proinflammatory and redox-modulatory effects of fatty acids or other food bioactive compounds.
C1 [Sureda, Antoni; Bibiloni, Maria del Mar; Bouzas, Cristina; Gallardo-Alfaro, Laura; Mateos, David; Capo, Xavier; Tur, Josep A.; Pons, Antoni] Univ Balearic Isl, Res Grp Community Nutr & Oxidat Stress, Palma De Mallorca 07122, Spain.
   [Sureda, Antoni; Bibiloni, Maria del Mar; Bouzas, Cristina; Gallardo-Alfaro, Laura; Mateos, David; Capo, Xavier; Tur, Josep A.; Pons, Antoni] IDISBA, Palma De Mallorca 07122, Spain.
   [Sureda, Antoni; Bibiloni, Maria del Mar; Bouzas, Cristina; Gallardo-Alfaro, Laura; Mateos, David; Capo, Xavier; Tur, Josep A.; Pons, Antoni] Inst Salud Carlos III, CIBEROBN Physiopathol Obes & Nutr, Madrid 28029, Spain.
   [Sureda, Antoni; Bibiloni, Maria del Mar; Bouzas, Cristina; Gallardo-Alfaro, Laura; Mateos, David; Capo, Xavier; Tur, Josep A.; Pons, Antoni] Fundacio Inst Invest Sanitaria Illes Balears, IDISBA Inst Invest Sanitaria Illes Balears, Palma De Mallorca 07120, Spain.
   [Martorell, Miquel] Univ Concepcion, Fac Pharm, Dept Nutr & Dietet, Concepcion 4070386, Chile.
C3 Universitat de les Illes Balears; Institut Investigacio Sanitaria Illes
   Balears (IdISBa); Instituto de Salud Carlos III; CIBER - Centro de
   Investigacion Biomedica en Red; CIBEROBN; Institut Investigacio
   Sanitaria Illes Balears (IdISBa); Universidad de Concepcion
RP Tur, JA (corresponding author), Univ Balearic Isl, Res Grp Community Nutr & Oxidat Stress, Palma De Mallorca 07122, Spain.; Tur, JA (corresponding author), IDISBA, Palma De Mallorca 07122, Spain.; Tur, JA (corresponding author), Inst Salud Carlos III, CIBEROBN Physiopathol Obes & Nutr, Madrid 28029, Spain.; Tur, JA (corresponding author), Fundacio Inst Invest Sanitaria Illes Balears, IDISBA Inst Invest Sanitaria Illes Balears, Palma De Mallorca 07120, Spain.
EM antoni.sureda@uib.es; martorellpons@gmail.com; mar.bibiloni@uib.es;
   cristinabouvel@gmail.com; lauragala3@gmail.com; david-mateos@hotmail.es;
   xavier.capo@uib.es; pep.tur@uib.es; antonipons@uib.es
RI Tur, Josep/AAE-5748-2020; Bouzas, Cristina/AAE-2069-2019; Mateos,
   David/N-7366-2018; del Mar Bibiloni, Maria/M-3123-2014; Sureda,
   Antoni/N-9588-2019; Capò, Xavier/AAL-4246-2020; Gallardo-Alfaro,
   Laura/AAB-3363-2021; Tur, Josep/F-5576-2014; Martorell,
   Miquel/H-8490-2014; Pons, Antoni/L-4844-2014
OI Gallardo Alfaro, Laura/0000-0002-5769-706X; Bibiloni Esteva, Maria del
   Mar/0000-0001-8926-9206; , Antoni/0000-0001-8656-6838; Tur,
   Josep/0000-0002-6940-0761; Martorell, Miquel/0000-0003-3183-7623; Bouzas
   Velasco, Cristina/0000-0002-1407-8461; Pons, Antoni/0000-0003-2447-3868;
   Capo Fiol, Xavier/0000-0002-3499-5494
FU European Regional Development Fund [PI14/00636, PI17/01827, Red
   Predimed-RETIC RD06/0045/1004, CIBEROBN CB12/03/30038]; EU-COST Action
   [CA16112]; IDISBA Grant (FOLIUM); IDISBA Grant (PRIMUS); IDISBA Grant
   (SYNERGIA); IDISBA Grant (LIBERI); Fundacio La Marato TV3 (Spain)
   [201630.10]; Spanish Ministry of Education; Vicerrectoria de
   Investigacion y Desarrollo from University of Concepcion, Chile
   [216.073.031-1.0IN]; Balearic Islands Gov. [35/2011]; Fernando Tarongi
   Bauza PhD Grant
FX Instituto de Salud Carlos III through the Fondo de Investigacion para la
   Salud (FIS), which is cofunded by the European Regional Development Fund
   (Projects PI14/00636 and PI17/01827, Red Predimed-RETIC RD06/0045/1004,
   and CIBEROBN CB12/03/30038), EU-COST Action CA16112; Grant of support to
   research groups no. 35/2011 (Balearic Islands Gov.), IDISBA Grants
   (FOLIUM, PRIMUS, SYNERGIA, and LIBERI), and Fundacio La Marato TV3
   (Spain) project ref. 201630.10. C.B. received a Fernando Tarongi Bauza
   PhD Grant. L.G.-A. received an FPU PhD Grant from the Spanish Ministry
   of Education. M.M. was funded by Vicerrectoria de Investigacion y
   Desarrollo from University of Concepcion, Chile (216.073.031-1.0IN). The
   funding sponsors had no role in the design of the study, in the
   collection, analyses, or interpretation of the data; in the writing of
   the manuscript, or in the decision to publish the results.
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NR 62
TC 18
Z9 19
U1 0
U2 12
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JAN
PY 2020
VL 12
IS 1
AR 146
DI 10.3390/nu12010146
PG 13
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA KQ3KN
UT WOS:000516825500146
PM 31947975
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU van Niekerk, G
   du Toit, A
   Loos, B
   Engelbrecht, AM
AF van Niekerk, Gustav
   du Toit, Andre
   Loos, Ben
   Engelbrecht, Anna-Mart
TI Nutrient excess and autophagic deficiency: explaining metabolic diseases
   in obesity
SO METABOLISM-CLINICAL AND EXPERIMENTAL
LA English
DT Review
DE Autophagy; Metabolic endotoxemia; Metabolic syndrome; Obesity;
   Paleolithic diet
ID PANCREATIC INSUFFICIENCY; INSULIN-RESISTANCE; MEDIATED AUTOPHAGY;
   ADIPOSE-TISSUE; CELL-DEATH; ER STRESS; CLEARANCE; DIET; INFLAMMASOMES;
   INFLAMMATION
AB Over-nutrition and a sedentary lifestyle are the driving forces behind the development of metabolic diseases. Conversely, caloric restriction and exercise have proven to be the most effective strategies in combating metabolic diseases. Interestingly, exercise and caloric restriction share a common feature: both represent a potent mechanism for upregulating autophagy. Autophagy is rapidly induced by nutrient deprivation, and conversely, inactivated by amino acids as well as growth factors (e.g. insulin). Here, we review evidence demonstrating that autophagy may indeed be attenuated in metabolic tissue such as liver, muscle, and adipose, in the context of obesity. We also highlight the mechanistic basis by which defective autophagy may contribute to the manifestation of metabolic diseases. This includes a compromised ability of the cell to perform quality control on the mitochondrial matrix, since autophagy plays a pivotal role in the degradation of defective mitochondria. Similarly, autophagy also plays an indispensable role in the clearance of protein aggregates and redundant large protein platforms such as inflammasomes. Autophagy might also play a key role in the metabolism of endotoxins, implicating the importance of autophagy in the pathogenesis of metabolic endotoxemia. These observations underpin an unprecedented role of autophagy in the manifestation of obesity-induced metabolic derangement. (C) 2017 Elsevier Inc. All rights reserved.
C1 [van Niekerk, Gustav; du Toit, Andre; Loos, Ben; Engelbrecht, Anna-Mart] Stellenbosch Univ, Dept Physiol Sci, Stellenbosch, South Africa.
C3 Stellenbosch University
RP van Niekerk, G (corresponding author), Stellenbosch Univ, Dept Physiol Sci, Stellenbosch, South Africa.
EM 14088576@sun.ac.za
RI Loos, Benjamin/G-3716-2012; Engelbrecht, Anna-Mart/B-5846-2011
OI Loos, Ben/0000-0002-5517-373X; Engelbrecht,
   Anna-Mart/0000-0003-1469-0148; du Toit, Andre/0000-0002-3936-6013; van
   Niekerk, Gustav/0000-0001-5530-6830
FU Cancer Association of South Africa (CANSA); National Research Foundation
   (NRF) [99093]; Medical Research Council of South Africa (SAMRC)
   [S16/02/036]
FX The authors acknowledge funding support from the Cancer Association of
   South Africa (CANSA), National Research Foundation (NRF) (99093) and the
   Medical Research Council of South Africa (SAMRC) (S16/02/036).
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NR 64
TC 26
Z9 29
U1 0
U2 15
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0026-0495
EI 1532-8600
J9 METABOLISM
JI Metab.-Clin. Exp.
PD MAY
PY 2018
VL 82
BP 14
EP 21
DI 10.1016/j.metabol.2017.12.007
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA GI2ZD
UT WOS:000434239500002
PM 29289514
DA 2025-06-11
ER

PT J
AU Dong, JL
   Yu, X
   Dong, LE
   Shen, RL
AF Dong, Ji-lin
   Yu, Xiao
   Dong, Liang-er
   Shen, Rui-ling
TI In vitro fermentation of oat -glucan and hydrolysates by fecal
   microbiota and selected probiotic strains
SO JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
LA English
DT Article
DE in vitro fermentation; molecular weight; oat -glucan hydrolysates;
   prebiotocs; probiotics
ID INDUCED DIABETIC MICE; BARLEY BETA-GLUCAN; MOLECULAR-WEIGHT;
   PHYSICOCHEMICAL PROPERTIES; METABOLIC SYNDROME; GUT MICROBIOTA; OBESITY;
   ACID; BACTERIA; STRESS
AB BACKGROUNDEmerging evidence suggested that the prebiotic ability of -glucan was intimately related to its molecular weight (M-w). However, the effect of oat -glucan with differing M-w on gut homeostasis was inconsistent. Importantly, knowledge of the fermentation properties of oat -glucan fractions was still limited. The present study aimed to evaluate the prebiotic potential of raw and hydrolyzed oat -glucan during in vitro fermentation by fecal microbiota and selected probiotic strains.
   RESULTSThe results obtained showed that both oat -glucan (OG) and hydrolysates (OGH) comparably promoted the growth of fecal Lactobacillus counts (P < 0.05). Importantly, OGH revealed greater fermentability compared to OG as denoted by lower pH value and higher short-chain fatty acid concentration (P < 0.05). Moreover, OGH was found to be more favorable to provide growth substrates for Lactobacillus helveticus R389 (LR389), Lactobacillus rhamnosus GG ATCC 53103 (LGG) and Bifidobacterium longum BB536 (BB536) than OG, and was preferentially utilized by LR389, LGG and BB536 as the sole carbon source.
   CONCLUSIONThe results of the present study indicate that oat -glucan hydrolysates could serve as a more promising material for developing novel symbiotic foods. (c) 2017 Society of Chemical Industry
C1 [Dong, Ji-lin; Yu, Xiao; Shen, Rui-ling] Zhengzhou Univ Light Ind, Coll Food & Biol Engn, Zhengzhou, Henan, Peoples R China.
   [Dong, Ji-lin; Yu, Xiao; Shen, Rui-ling] Henan Collaborat Innovat Ctr Food Prod & Safety, Zhengzhou, Henan, Peoples R China.
   [Dong, Liang-er] Univ Tennessee, Dept Food Sci & Technol, Knoxville, TN USA.
C3 Zhengzhou University of Light Industry; University of Tennessee System;
   University of Tennessee Knoxville; UT Institute of Agriculture
RP Shen, RL (corresponding author), Zhengzhou Univ Light Ind, Henan Collaborat Innovat Ctr Food Prod & Safety, Zhengzhou, Henan, Peoples R China.
EM shenrl1967@163.com
RI Dong, Lianger/IVH-4423-2023
FU Natural Science Foundation of China [31671856]
FX This research was supported by the Natural Science Foundation of China
   (No. 31671856). The authors declare that they have no conflicts of
   interest.
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NR 29
TC 36
Z9 37
U1 5
U2 92
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-5142
EI 1097-0010
J9 J SCI FOOD AGR
JI J. Sci. Food Agric.
PD SEP
PY 2017
VL 97
IS 12
BP 4198
EP 4203
DI 10.1002/jsfa.8292
PG 6
WC Agriculture, Multidisciplinary; Chemistry, Applied; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture; Chemistry; Food Science & Technology
GA FD4JT
UT WOS:000407498100036
PM 28244112
DA 2025-06-11
ER

PT J
AU Wang, J
   Li, YR
   Han, X
   Hu, H
   Wang, F
   Li, XL
   Yang, K
   Yuan, J
   Yao, P
   Miao, XP
   Wei, S
   Wang, YJ
   Cheng, WH
   Liang, Y
   Zhang, XM
   Guo, H
   Yang, HD
   Yuan, JM
   Koh, WP
   Hu, FB
   Wu, TC
   Pan, A
   He, MA
AF Wang, Jing
   Li, Yaru
   Han, Xu
   Hu, Hua
   Wang, Fei
   Li, Xiulou
   Yang, Kun
   Yuan, Jing
   Yao, Ping
   Miao, Xiaoping
   Wei, Sheng
   Wang, Youjie
   Cheng, Weihong
   Liang, Yuan
   Zhang, Xiaomin
   Guo, Huan
   Yang, Handong
   Yuan, Jianmin
   Koh, Woon-Puay
   Hu, Frank B.
   Wu, Tangchun
   Pan, An
   He, Meian
TI Serum bilirubin levels and risk of type 2 diabetes: results from two
   independent cohorts in middle-aged and elderly Chinese
SO SCIENTIFIC REPORTS
LA English
DT Article
ID METABOLIC SYNDROME; INSULIN-RESISTANCE; OXIDATIVE STRESS; HEART-DISEASE;
   MEN; HYPERBILIRUBINEMIA; ASSOCIATION; PATHWAYS; MICE
AB Serum bilirubin is a potent endogenous antioxidant and has been identified as cardiovascular risk in cohort studies, while the relation to type 2 diabetes (T2D) in the elderly remains unclear. We investigated both cross-sectional and prospective associations between serum bilirubin levels and T2D risk in the Dongfeng-Tongji (DFTJ) cohort, and replicated the prospective findings in a nested case-control study (509 cases and 509 controls) within the Singapore Chinese Health Study (SCHS). In the cross-sectional analysis of DFTJ cohort (15,575 participants with 2,532 diabetes cases), serum bilirubin levels (total, direct and indirect) increased in new on-set diabetes and decreased with the diabetic duration. In the longitudinal analysis of DFTJ cohort (772 incident diabetes cases during 4.5 years of follow-up among 12,530 diabetes-free participants at baseline), positive association was found between direct bilirubin and T2D risk comparing extreme quartiles, similar results were observed in the nested case-control study within SCHS. Total and indirect bilirubin levels were not significantly associated with T2D in either cohort. In conclusion, our findings do not support the protective association between serum bilirubin levels and incident T2D in the middle-aged and elderly adults; instead, direct bilirubin levels were associated with increased risk of T2D.
C1 [Wang, Jing; Li, Yaru; Han, Xu; Hu, Hua; Yuan, Jing; Yao, Ping; Wang, Youjie; Cheng, Weihong; Liang, Yuan; Zhang, Xiaomin; Guo, Huan; Wu, Tangchun; He, Meian] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Dept Environm & Occupat Hlth, Wuhan, Peoples R China.
   [Wang, Jing; Li, Yaru; Han, Xu; Hu, Hua; Wang, Fei; Yuan, Jing; Yao, Ping; Wang, Youjie; Cheng, Weihong; Liang, Yuan; Zhang, Xiaomin; Guo, Huan; Wu, Tangchun; He, Meian] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, State Key Lab Environm Hlth Incubating, Wuhan, Peoples R China.
   [Wang, Jing; Li, Xiulou; Yang, Kun; Yang, Handong] Dongfeng Motor Corp, Dongfeng Cent Hosp, Shiyan, Hubei, Peoples R China.
   [Wang, Jing; Li, Xiulou; Yang, Kun; Yang, Handong] Hubei Univ Med, Shiyan, Hubei, Peoples R China.
   [Miao, Xiaoping; Wei, Sheng; Pan, An] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Dept Biostat & Epidemiol, Wuhan, Peoples R China.
   [Yuan, Jianmin] Univ Pittsburgh, Inst Canc, Div Canc Control & Populat Sci, Pittsburgh, PA USA.
   [Yuan, Jianmin] Univ Pittsburgh, Grad Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA USA.
   [Koh, Woon-Puay] Duke NUS Med Sch, Singapore, Singapore.
   [Hu, Frank B.] Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA.
   [Hu, Frank B.] Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA.
C3 Huazhong University of Science & Technology; Huazhong University of
   Science & Technology; Dongfeng Motor; Hubei University of Medicine;
   Huazhong University of Science & Technology; Pennsylvania Commonwealth
   System of Higher Education (PCSHE); University of Pittsburgh;
   Pennsylvania Commonwealth System of Higher Education (PCSHE); University
   of Pittsburgh; National University of Singapore; Harvard University;
   Harvard T.H. Chan School of Public Health; Harvard University; Harvard
   T.H. Chan School of Public Health
RP He, MA (corresponding author), Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Dept Environm & Occupat Hlth, Wuhan, Peoples R China.; He, MA (corresponding author), Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, State Key Lab Environm Hlth Incubating, Wuhan, Peoples R China.; Pan, A (corresponding author), Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Dept Biostat & Epidemiol, Wuhan, Peoples R China.
EM panan@hust.edu.cn; hemeian@hotmail.com
RI Zhang, Xiaomin/F-3206-2018; wei, sheng/E-9746-2012; wang,
   jing/GVT-8700-2022; li, yan/GXH-7943-2022; yu, ye/KVB-7532-2024; Hu,
   Frank/C-1919-2013; Pan, An/C-5572-2011; miao, xiaoping/C-4336-2011
OI Pan, An/0000-0002-1089-7945; miao, xiaoping/0000-0002-6818-9722; Wang,
   Jing/0000-0003-4869-7719
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NR 46
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Z9 25
U1 1
U2 13
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD FEB 6
PY 2017
VL 7
AR 41338
DI 10.1038/srep41338
PG 8
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA EJ5SQ
UT WOS:000393278800001
PM 28164994
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Kim, J
   Kim, KM
   Noh, JH
   Yoon, JH
   Abdelmohsen, K
   Gorospe, M
AF Kim, Jiyoung
   Kim, Kyoung Mi
   Noh, Ji Heon
   Yoon, Je-Hyun
   Abdelmohsen, Kotb
   Gorospe, Myriam
TI Long noncoding RNAs in diseases of aging
SO BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
LA English
DT Review
DE Senescence; Age-associated disease; Ribonucleoprotein complexes;
   Transcriptional control; Post-transcriptional gene regulation;
   Differentiation; Myocytes; mRNA translation; mRNA stability;
   Transcriptome
ID CELL-CYCLE ARREST; NF-KAPPA-B; DIABETES-MELLITUS; POOR-PROGNOSIS;
   HEPATOCELLULAR-CARCINOMA; MUSCLE DIFFERENTIATION; EPIGENETIC REGULATION;
   METABOLIC SYNDROME; GLUCOSE-TOLERANCE; OXIDATIVE STRESS
AB Aging is a process during which progressive deteriorating of cells, tissues, and organs over time lead to loss of function, disease, and death. Towards the goal of extending human health span, there is escalating interest in understanding the mechanisms that govern aging-associated pathologies. Adequate regulation of expression of coding and noncoding genes is critical for maintaining organism homeostasis and preventing disease processes. Long noncoding RNAs (lncRNAs) are increasingly recognized as key regulators of gene expression at all levels transcriptional, post-transcriptional and post-translational. In this review, we discuss our emerging understanding of lncRNAs implicated in aging illnesses. We focus on diseases arising from age-driven impairment in energy metabolism (obesity, diabetes), the declining capacity to respond homeostatically to proliferative and damaging stimuli (cancer, immune dysfunction), and neurodegeneration. We identify the lncRNAs involved in these ailments and discuss the rising interest in lncRNAs as diagnostic and therapeutic targets to ameliorate age associated pathologies and prolong health. This article is part of a Special Issue entitled: Clues to long noncoding RNA taxonomy1, edited by Dr. Tetsuro Hirose and Dr. Shinichi Nakagawa. Published by Elsevier B.V.
C1 [Kim, Jiyoung; Kim, Kyoung Mi; Noh, Ji Heon; Yoon, Je-Hyun; Abdelmohsen, Kotb; Gorospe, Myriam] NIA, Genet Lab, Intramural Res Program, NIH, 251 Bayview Blvd, Baltimore, MD 21224 USA.
C3 National Institutes of Health (NIH) - USA; NIH National Institute on
   Aging (NIA)
RP Abdelmohsen, K; Gorospe, M (corresponding author), NIA, Genet Lab, Intramural Res Program, NIH, 251 Bayview Blvd, Baltimore, MD 21224 USA.
EM abdelmohsenk@mail.nih.gov; myriam-gorospe@nih.gov
RI Abdelmohsen, Kotb/AAX-4191-2020; Gorospe, Myriam/Y-3613-2019; Kim,
   Kyoung Mi/AAE-9847-2021
OI Kim, Jiyoung/0000-0002-2938-3995; Kim, Kyoung Mi/0000-0002-2845-5678;
   Yoon, Je-Hyun/0000-0001-7615-8654
FU National Institute on Aging-Intramural Research Program of the National
   Institutes of Health
FX This work was supported in its entirety by the National Institute on
   Aging-Intramural Research Program of the National Institutes of Health.
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NR 227
TC 64
Z9 74
U1 1
U2 20
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1874-9399
EI 1876-4320
J9 BBA-GENE REGUL MECH
JI Biochim. Biophys. Acta-Gene Regul. Mech.
PD JAN
PY 2016
VL 1859
IS 1
BP 209
EP 221
DI 10.1016/j.bbagrm.2015.06.013
PG 13
WC Biochemistry & Molecular Biology; Biophysics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics
GA DB8DQ
UT WOS:000368747600025
PM 26141605
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Foroudi, S
   Potter, AS
   Stamatikos, A
   Patil, BS
   Deyhim, F
AF Foroudi, Shahrzad
   Potter, Andrew S.
   Stamatikos, Alexis
   Patil, Bhimanagouda S.
   Deyhim, Farzad
TI Drinking Orange Juice Increases Total Antioxidant Status and Decreases
   Lipid Peroxidation in Adults
SO JOURNAL OF MEDICINAL FOOD
LA English
DT Article
DE antioxidant status; cardiovascular disease; lipid peroxidation; orange
   juice
ID CORONARY-HEART-DISEASE; VEGETABLE CONSUMPTION; CARDIOVASCULAR-DISEASE;
   METABOLIC-SYNDROME; OXIDATIVE STRESS; DIETARY FATS; MIXED FRUIT; RISK;
   ASSOCIATION; COHORT
AB Cardiovascular disease (CVD) is the leading cause of death in the world and is the primary cause of mortality among Americans. One of the many reasons for the pathogenesis of CVD is attributed to eating diets high in saturated fat and refined carbohydrates and low in fruits and vegetables. Epidemiological evidence has supported a strong association between eating diets rich in fruits and vegetables and cardiovascular health. An experiment was conducted utilizing 24 adults with hypercholesterolemia and hypertriglyceridemia to evaluate the impact of drinking 20 fl oz of freshly squeezed orange juice daily for 90 days on blood pressure, lipid panels, plasma antioxidant capacity, metabolic hormones, lipid peroxidation, and inflammatory markers. Except for addition of drinking orange juice, subjects did not modify their eating habits. The findings suggested that drinking orange juice does not affect (P>.1) blood pressure, lipid panels, metabolic hormones, body fat percentage, or inflammatory markers. However, total plasma antioxidant capacity was significantly increased (P<.05) and lipid peroxidation was significantly decreased (P<.05) after orange juice consumption. Drinking orange juice may protect the cardiovascular system by increasing total plasma antioxidant status and by lowering lipid peroxidation independent of other cardiovascular risk markers evaluated in this study.
C1 [Foroudi, Shahrzad; Potter, Andrew S.; Stamatikos, Alexis; Deyhim, Farzad] Texas A&M Univ, Dept Human Sci, Kingsville, TX 78363 USA.
   [Patil, Bhimanagouda S.; Deyhim, Farzad] Texas A&M Univ, Dept Hort Sci, Vegetable & Fruit Improvement Ctr, College Stn, TX 77843 USA.
   [Deyhim, Farzad] Texas A&M Univ Kingsville, Citrus Ctr, Weslaco, TX USA.
C3 Texas A&M University System; Texas A&M University Kingsville; Texas A&M
   University System; Texas A&M University College Station; Texas A&M
   University System; Texas A&M University Kingsville
RP Deyhim, F (corresponding author), Texas A&M Univ, Dept Human Sci, MSC 168, Kingsville, TX 78363 USA.
EM farzad.deyhim@tamuk.edu
RI Patil, Bhimanagouda/C-7620-2013
OI Patil, Bhimanagouda/0000-0001-7189-0432; Stamatikos,
   Alexis/0000-0003-0162-8521
FU USDA-CSREES through the Vegetable & Fruit Improvement Center
   [2008-34402-19195, 2010-34402-20875]
FX This project is based upon work supported by the USDA-CSREES nos.
   2008-34402-19195 and 2010-34402-20875 "Designing Foods for Health"
   through the Vegetable & Fruit Improvement Center.
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NR 48
TC 19
Z9 19
U1 0
U2 17
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1096-620X
EI 1557-7600
J9 J MED FOOD
JI J. Med. Food
PD MAY
PY 2014
VL 17
IS 5
BP 612
EP 617
DI 10.1089/jmf.2013.0034
PG 6
WC Chemistry, Medicinal; Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Food Science & Technology; Nutrition &
   Dietetics
GA AH6CE
UT WOS:000336217500012
PM 24476220
DA 2025-06-11
ER

PT J
AU Deetman, PE
   Kwakernaak, AJ
   Bakker, SJL
   Dullaart, RPF
AF Deetman, Petronella E.
   Kwakernaak, Arjan J.
   Bakker, Stephan J. L.
   Dullaart, Robin P. F.
TI Low-Normal Free Thyroxine Confers Decreased Serum Bilirubin in Type 2
   Diabetes Mellitus
SO THYROID
LA English
DT Article
ID INTIMA-MEDIA THICKNESS; CORONARY-HEART-DISEASE; THYROID-HORMONE;
   SUBCLINICAL HYPOTHYROIDISM; METABOLIC SYNDROME; OXIDATIVE STRESS; PLASMA
   BILIRUBIN; HEME OXYGENASE; RISK; HEALTH
AB Background: Bilirubin may confer cardiovascular protection because of its strong antioxidative properties. Both thyroid dysfunction and the diabetic state affect bilirubin metabolism. Here we tested whether low-normal thyroid function affects serum bilirubin among euthyroid subjects with and without type 2 diabetes mellitus (T2DM). Methods: Serum total bilirubin, thyrotropin and free thyroxine (free T4), transaminases, insulin sensitivity (homeostasis model assessment), and lipids were measured in 74 T2DM and 82 nondiabetic subjects with thyrotropin and free T4 levels within the euthyroid range. Results: Bilirubin was positively related to free T4 in T2DM subjects (r=0.370, p<0.001), but not in nondiabetic subjects (r=0.047, p=0.68). In age- and sex-adjusted multiple linear regression analysis, free T4 was found to interact positively with the presence of T2DM on serum bilirubin (interaction term: =0.251, p=0.024). This interaction remained present after additional adjustment for alcohol intake, aspartate aminotransferase and insulin sensitivity (interaction term: =0.222, p=0.043), or alternatively for cholesterol and triglycerides (interaction term: =0.203, p=0.057). Conclusions: Lower free T4 levels within the euthyroid range confer decreased bilirubin in T2DM. Low-normal thyroid function could enhance atherosclerosis susceptibility in T2DM by decreasing serum bilirubin.
C1 Univ Groningen, Univ Med Ctr Groningen, Dept Internal Med, NL-9700 RB Groningen, Netherlands.
   Univ Groningen, Univ Med Ctr Groningen, NL-9700 RB Groningen, Netherlands.
C3 University of Groningen; University of Groningen
RP Dullaart, RPF (corresponding author), Univ Groningen, Univ Med Ctr Groningen, Dept Internal Med, POB 30001, NL-9700 RB Groningen, Netherlands.
EM r.p.f.dullaart@umcg.nl
RI Bakker, Stephan/J-4023-2015
OI Bakker, Stephan/0000-0003-3356-6791
FU Dutch Diabetes Research Foundation [2001.00.012]
FX This study is in part supported by Grant 2001.00.012 from the Dutch
   Diabetes Research Foundation. We appreciate the dedicated technical
   assistance of Dr. R. de Vries, MD, PhD, in performing the clinical
   experiments. Thyroid function parameters were determined in the
   laboratory of Dr. A. C. Muller-Kobold, Laboratory Center, University
   Medical Center Groningen, Groningen, The Netherlands.
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NR 43
TC 8
Z9 10
U1 0
U2 5
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1050-7256
EI 1557-9077
J9 THYROID
JI Thyroid
PD NOV 1
PY 2013
VL 23
IS 11
BP 1367
EP 1373
DI 10.1089/thy.2013.0156
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 246YV
UT WOS:000326578800003
PM 23638994
OA Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Hernández-Aguilera, A
   Rull, A
   Rodríguez-Gallego, E
   Riera-Borrull, M
   Luciano-Mateo, F
   Camps, J
   Menéndez, JA
   Joven, J
AF Hernandez-Aguilera, Anna
   Rull, Anna
   Rodriguez-Gallego, Esther
   Riera-Borrull, Marta
   Luciano-Mateo, Fedra
   Camps, Jordi
   Menendez, Javier A.
   Joven, Jorge
TI Mitochondrial Dysfunction: A Basic Mechanism in Inflammation-Related
   Non-Communicable Diseases and Therapeutic Opportunities
SO MEDIATORS OF INFLAMMATION
LA English
DT Review
ID ACTIVATED PROTEIN-KINASE; FATTY LIVER-DISEASE; MONOCYTE CHEMOATTRACTANT
   PROTEIN-1; ADIPOSE-TISSUE; OXIDATIVE STRESS; SKELETAL-MUSCLE;
   INSULIN-RESISTANCE; HEPATIC GLUCONEOGENESIS; MOLECULAR-MECHANISMS;
   METABOLIC SYNDROME
AB Obesity is not necessarily a predisposing factor for disease. It is the handling of fat and/or excessive energy intake that encompasses the linkage of inflammation, oxidation, and metabolism to the deleterious effects associated with the continuous excess of food ingestion. The roles of cytokines and insulin resistance in excessive energy intake have been studied extensively. Tobacco use and obesity accompanied by an unhealthy diet and physical inactivity are the main factors that underlie noncommunicable diseases. The implication is that the management of energy or food intake, which is the main role of mitochondria, is involved in the most common diseases. In this study, we highlight the importance of mitochondrial dysfunction in the mutual relationships between causative conditions. Mitochondria are highly dynamic organelles that fuse and divide in response to environmental stimuli, developmental status, and energy requirements. These organelles act to supply the cell with ATP and to synthesise key molecules in the processes of inflammation, oxidation, and metabolism. Therefore, energy sensors and management effectors are determinants in the course and development of diseases. Regulating mitochondrial function may require a multifaceted approach that includes drugs and plant-derived phenolic compounds with antioxidant and anti-inflammatory activities that improve mitochondrial biogenesis and act to modulate the AMPK/mTOR pathway.
C1 [Hernandez-Aguilera, Anna; Rull, Anna; Rodriguez-Gallego, Esther; Riera-Borrull, Marta; Luciano-Mateo, Fedra; Camps, Jordi; Joven, Jorge] Univ Rovira & Virgili, Hosp Univ St Joan, Unitat Recerca Biomed, Inst Invest Sanitaria Pere Virgili, E-43201 Reus, Spain.
   [Menendez, Javier A.] Catalan Inst Oncol, Girona 1707, Spain.
   [Menendez, Javier A.] Girona Biomed Res Inst, Girona 1707, Spain.
C3 Universitat Rovira i Virgili; Institut d'Investigacio Sanitaria Pere
   Virgili (IISPV); Institut Catala d'Oncologia; Universitat de Girona;
   Girona University Hospital Dr. Josep Trueta; Institut d'Investigacio
   Biomedica de Girona (IDIBGI)
RP Joven, J (corresponding author), Univ Rovira & Virgili, Hosp Univ St Joan, Unitat Recerca Biomed, Inst Invest Sanitaria Pere Virgili, Carrer St Llorenc 21, E-43201 Reus, Spain.
EM jjoven@grupsagessa.com
RI Rull, Anna/A-9438-2017; Camps, Jordi/AAG-3080-2020; Rodriguez-Gallego,
   Esther/B-6581-2016; MENENDEZ MENENDEZ, JAVIER ABEL/C-6148-2016; Joven,
   Jorge/B-3360-2016
OI Hernandez-Aguilera, Anna/0000-0003-0954-295X; Luciano-Mateo,
   Fedra/0000-0002-8736-2455; Rodriguez-Gallego,
   Esther/0000-0002-6363-2510; Rull, Anna/0000-0002-8907-7754; MENENDEZ
   MENENDEZ, JAVIER ABEL/0000-0001-8733-4561; Riera-Borrull,
   Marta/0000-0003-4670-7290; Joven, Jorge/0000-0003-2749-4541
FU Fondo de Investigacion Sanitaria [FIS PI08/1032, PI11/00130];
   Generalitat de Catalunya [2012FI_B 00389]; Universitat Rovira i Virgili
   [2010PFR-URV-B2-58]
FX The Unitat de Recerca Biomedica is currently being supported by Grants
   from the Fondo de Investigacion Sanitaria (FIS PI08/1032, PI11/00130).
   E. Rodriguez-Gallego is the recipient of a fellowship from the
   Generalitat de Catalunya (2012FI_B 00389), and M. Riera-Borrull is the
   recipient of a fellowship from the Universitat Rovira i Virgili
   (2010PFR-URV-B2-58).
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NR 128
TC 100
Z9 105
U1 2
U2 7
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 0962-9351
EI 1466-1861
J9 MEDIAT INFLAMM
JI Mediat. Inflamm.
PY 2013
VL 2013
AR 135698
DI 10.1155/2013/135698
PG 13
WC Cell Biology; Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Immunology
GA 103BW
UT WOS:000315890300001
PM 23533299
OA Green Submitted, gold, Green Published
DA 2025-06-11
ER

PT J
AU Enayati, A
   Ghojoghnejad, M
   Roufogalis, BD
   Maollem, SA
   Sahebkar, A
AF Enayati, Ayesheh
   Ghojoghnejad, Mobina
   Roufogalis, Basil D.
   Maollem, Seyed Adel
   Sahebkar, Amirhossein
TI Impact of Phytochemicals on PPAR Receptors: Implications for Disease
   Treatments
SO PPAR RESEARCH
LA English
DT Review
ID NF-KAPPA-B; AMELIORATES COGNITIVE DEFICITS; DECREASES PLASMA
   TRIGLYCERIDE; NLRP3 INFLAMMASOME ACTIVATION; PREVENTS RENAL
   LIPOTOXICITY; INDUCED FATTY LIVER; URSOLIC ACID; SIGNALING PATHWAY;
   RESVERATROL PREVENTS; OXIDATIVE STRESS
AB Peroxisome proliferator-activated receptors (PPARs) are members of the ligand-dependent nuclear receptor family. PPARs have attracted wide attention as pharmacologic mediators to manage multiple diseases and their underlying signaling targets. They mediate a broad range of specific biological activities and multiple organ toxicity, including cellular differentiation, metabolic syndrome, cancer, atherosclerosis, neurodegeneration, cardiovascular diseases, and inflammation related to their up/downstream signaling pathways. Consequently, several types of selective PPAR ligands, such as fibrates and thiazolidinediones (TZDs), have been approved as their pharmacological agonists. Despite these advances, the use of PPAR agonists is known to cause adverse effects in various systems. Conversely, some naturally occurring PPAR agonists, including polyunsaturated fatty acids and natural endogenous PPAR agonists curcumin and resveratrol, have been introduced as safe agonists as a result of their clinical evidence or preclinical experiments. This review focuses on research on plant-derived active ingredients (natural phytochemicals) as potential safe and promising PPAR agonists. Moreover, it provides a comprehensive review and critique of the role of phytochemicals in PPARs-related diseases and provides an understanding of phytochemical-mediated PPAR-dependent and -independent cascades. The findings of this research will help to define the functions of phytochemicals as potent PPAR pharmacological agonists in underlying disease mechanisms and their related complications.
C1 [Enayati, Ayesheh; Ghojoghnejad, Mobina] Golestan Univ Med Sci, Ischem Disorders Res Ctr, Gorgan, Iran.
   [Roufogalis, Basil D.] Univ Sydney, Sch Med Sci, Discipline Pharmacol, Sydney, NSW, Australia.
   [Roufogalis, Basil D.] Western Sydney Univ, NICM Hlth Res Inst, Penrith, NSW, Australia.
   [Maollem, Seyed Adel] Al Zahraa Univ Women, Coll Pharm, Dept Pharmacol & Toxicol, Karbala, Iraq.
   [Maollem, Seyed Adel] Mashhad Univ Med Sci, Sch Pharm, Dept Pharmacodynam & Toxicol, Mashhad, Iran.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Biotechnol Res Ctr, Mashhad, Iran.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Appl Biomed Res Ctr, Mashhad, Iran.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Sch Pharm, Dept Biotechnol, Mashhad, Iran.
C3 Golestan University of Medical Sciences; University of Sydney; Western
   Sydney University; Al-Zahraa University for Women; Mashhad University of
   Medical Sciences; Mashhad University of Medical Sciences; Mashhad
   University of Medical Sciences; Mashhad University of Medical Sciences
RP Sahebkar, A (corresponding author), Mashhad Univ Med Sci, Pharmaceut Technol Inst, Biotechnol Res Ctr, Mashhad, Iran.; Sahebkar, A (corresponding author), Mashhad Univ Med Sci, Appl Biomed Res Ctr, Mashhad, Iran.; Sahebkar, A (corresponding author), Mashhad Univ Med Sci, Sch Pharm, Dept Biotechnol, Mashhad, Iran.
EM enayatia@yandex.com; ghojoghnejadm@yandex.com;
   basil.roufogalis@sydney.edu.au; moallemsa@yandex.com;
   amir_saheb2000@yahoo.com
RI Roufogalis, Basil/M-3812-2013; Enayati, Ayesheh/AAK-8211-2021; Sahebkar,
   Amirhossein/B-5124-2018
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NR 274
TC 25
Z9 25
U1 1
U2 8
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1687-4757
EI 1687-4765
J9 PPAR RES
JI PPAR Res.
PD AUG 31
PY 2022
VL 2022
AR 4714914
DI 10.1155/2022/4714914
PG 43
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 5A8JK
UT WOS:000863127300001
PM 36092543
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Sanchez-Autet, M
   Arranz, B
   Sierra, P
   Safont, G
   Garcia-Blanco, A
   de la Fuente, L
   Garriga, M
   Marín, L
   García-Portilla, MP
AF Sanchez-Autet, Monica
   Arranz, Belen
   Sierra, Pilar
   Safont, Gemma
   Garcia-Blanco, Ana
   de la Fuente, Lorena
   Garriga, Marina
   Marin, Lorena
   Paz Garcia-Portilla, Maria
TI Association between neutrophil-lymphocyte ratio, platelet-lymphocyte
   ratio, and C-reactive protein levels and metabolic status in patients
   with a bipolar disorder
SO WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
LA English
DT Article
DE Bipolar affective disorder; glucose metabolism; inflammation; C-reactive
   protein
ID INSULIN-RESISTANCE; CARDIOVASCULAR RISK; OXIDATIVE STRESS; INFLAMMATION;
   SCHIZOPHRENIA; CYTOKINES; SEVERITY; BLOOD; NEUROPROGRESSION;
   HOMOCYSTEINE
AB Objectives Neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and C-Reactive Protein (CRP) are markers of inflammation that are elevated in bipolar disorder (BD) and are also related to a higher risk of metabolic syndrome (MetS). This study aimed at investigating for the first time the association between NLR, PLR, and CRP and the metabolic status in BD. Methods We assessed the association between biomarkers and the metabolic status: number of metabolic risk factors, presence of MetS, insulin sensitivity (Quantitative Insulin Sensitivity Check Index, QUICKI) and insulin resistance (Homeostatic Model Assessment for Insulin Resistance, HOMA-IR index), in a sample of 219 outpatients with BD. Results 25.9% of the sample met the criteria for MetS. High levels of CRP were found in 12% of the sample. Older age, low PLR, high NLR, and high CRP levels significantly predicted a higher number of MetS risk factors (p < 0.001). Older age and low PLR were associated with a greater likelihood of developing MetS (p = 0.007). Conclusions Although further studies are needed to replicate and validate these findings, inflammatory biomarkers as CRP, PLR and NLR could be useful tools to identify patients with a BD at risk for a metabolic adverse outcome.
C1 [Sanchez-Autet, Monica; Arranz, Belen] Parc Sanitari St Joan Deu, Mossen Andreu 13, Barcelona 08940, Spain.
   [Arranz, Belen; Safont, Gemma; de la Fuente, Lorena; Garriga, Marina; Paz Garcia-Portilla, Maria] Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain.
   [Sierra, Pilar] La Fe Univ & Polytech Hosp, Dept Psychiat, Valencia, Spain.
   [Sierra, Pilar] Univ Valencia, Dept Med, Valencia, Spain.
   [Safont, Gemma; Marin, Lorena] Hosp Univ Mutua Terrassa, Barcelona, Spain.
   [Garcia-Blanco, Ana] La Fe Hlth Res Inst, Neonatal Res Unit, Valencia, Spain.
   [de la Fuente, Lorena; Paz Garcia-Portilla, Maria] Univ Oviedo, Dept Psychiat, Oviedo, Spain.
   [Garriga, Marina] Univ Barcelona, Hosp Clin, Inst Neurosci, Bipolar Disorder Unit, Barcelona, Spain.
C3 CIBER - Centro de Investigacion Biomedica en Red; CIBERSAM; University
   of Valencia; Hospital Universitario Mutua Terrassa; University of
   Oviedo; University of Barcelona; Hospital Clinic de Barcelona
RP Arranz, B (corresponding author), Parc Sanitari St Joan Deu, Mossen Andreu 13, Barcelona 08940, Spain.
EM belen.arranz@sjd.es
RI de la Fuente-Tomás, Lorena/O-6300-2018; Sanchez, Monica/ABI-6419-2020;
   Garcia-Portilla, Paz/AAC-8272-2020; Garcia-Blanco, Ana C./I-1928-2017
OI Garcia-Portilla, Paz/0000-0003-3643-1622; Safont,
   Gemma/0000-0001-5122-9161; Garcia-Blanco, Ana C./0000-0002-7840-000X;
   Arranz, Belen/0000-0003-3927-8803; Garriga, Marina/0000-0001-7312-4969;
   Sanchez-Autet, Monica/0000-0003-1349-9042; Sierra,
   Pilar/0000-0001-6132-5608
FU Instituto de Salud Carlos III [PI11/02493, FIS PI14/02037]; Fondos
   Europeos de Desarrollo Regional (FEDER)
FX This study was supported by grants from the Instituto de Salud Carlos
   III [PI11/02493 and FIS PI14/02037) and from Fondos Europeos de
   Desarrollo Regional (FEDER). The sponsors had no involvement in the
   study design, collection, analysis, and interpretation of data, in the
   writing of the report, and in the decision to submit the article for
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NR 76
TC 7
Z9 7
U1 0
U2 15
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1562-2975
EI 1814-1412
J9 WORLD J BIOL PSYCHIA
JI World J. Biol. Psychiatry
PD JUL 3
PY 2022
VL 23
IS 6
BP 464
EP 474
DI 10.1080/15622975.2021.2013089
EA JAN 2022
PG 11
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychiatry
GA 6C2JG
UT WOS:000741781500001
PM 34856870
DA 2025-06-11
ER

PT J
AU Berecova, Z
   Juskanic, D
   Simkova, J
   Simkova, I
AF Berecova, Zuzana
   Juskanic, Dominik
   Simkova, Jana
   Simkova, Iveta
TI Dual-energy Computed Tomography Delayed Myocardial Enhancement in the
   Diagnostic Dilemma of True versus False Left Ventricular Aneurysm - A
   Case Report
SO JOURNAL OF CLINICAL IMAGING SCIENCE
LA English
DT Article
DE Dual-energy computed tomography; Delayed myocardial enhancement; Left
   ventricle aneurysm; Left ventricle pseudoaneurysm
ID CT; INTERMEDIATE; ANGIOGRAPHY; INFARCTION; PERFUSION; STRESS; REST
AB The aim of this case report is to show the capability of cardiac computed tomography (CT) in combination with dual-energy CT (DECT) delayed myocardial enhancement to support diagnostic decision making in the complicated differential diagnosis of true versus false left ventricle (LV) aneurysm, as well as provide additional information that can influence overall patient outcome. We present a 71-year-old obese patient with metabolic syndrome, stable chronic coronary syndrome with three-vessel disease, and recent chest discomfort. His coronary angiogram showed no significant coronary artery stenosis, but suspicion of LV apical pseudoaneurysm was expressed. Neither transthoracic nor transesophageal echocardiography was able to dismiss this suspicion. Consequently, coronary CT angiography (CCTA) followed by DECT delayed myocardial enhancement was performed. Findings on CCTA and DECT confirmed the diagnosis of a true aneurysm. Moreover, fibrotic changes within the hypertrophic myocardium were visualized. This finding will influence further patient therapy as well as the outcome. DECT delayed myocardial enhancement can be an important complementary tool for distinguishing true versus false LV aneurysms. Moreover, it can provide additional information for making complex diagnose. Adding DECT delayed myocardial enhancement to CCTA can replace cardiac magnetic resonance imaging evaluation in certain settings.
C1 [Berecova, Zuzana] Slovak Med Univ, Univ Hosp, Radiodiagnost Clin, Bratislava, Slovakia.
   [Berecova, Zuzana] St Michal Hosp, Bratislava, Slovakia.
   [Juskanic, Dominik] Diagnost Ctr, Jesenius, Nitra, Slovakia.
   [Simkova, Jana] Inst Diagnost Imaging, Trnava, Slovakia.
   [Simkova, Iveta] Natl Inst Cardiovasc Dis, Dept Cardiol & Angiol, Bratislava, Slovakia.
C3 Slovak Medical University Bratislava
RP Berecova, Z (corresponding author), Slovak Med Univ, Univ Hosp, Radiodiagnost Clin, Bratislava, Slovakia.; Berecova, Z (corresponding author), St Michal Hosp, Bratislava, Slovakia.
EM hapka78@hotmail.com
RI Berecova, Zuzana/AAD-7254-2019
OI Berecova, Zuzana/0000-0002-7612-6641; Simkova, Iveta/0000-0002-6051-2724
CR Bettencourt N, 2013, JACC-CARDIOVASC IMAG, V6, P1062, DOI 10.1016/j.jcmg.2013.04.013
   Bisoyi S, 2016, ANN CARD ANAESTH, V19, P169, DOI 10.4103/0971-9784.173042
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NR 10
TC 4
Z9 4
U1 0
U2 2
PU SCIENTIFIC SCHOLAR LLC
PI PITTSFORD
PA 50, WOODGREEN DR, PITTSFORD, NY 14534 USA
SN 2156-7514
EI 2156-5597
J9 J CLIN IMAG SCI
JI J. Clin. Imag. Sci.
PD APR 16
PY 2021
VL 11
DI 10.25259/JCIS_28_2021
PG 5
WC Radiology, Nuclear Medicine & Medical Imaging
WE Emerging Sources Citation Index (ESCI)
SC Radiology, Nuclear Medicine & Medical Imaging
GA SX2WP
UT WOS:000665071300001
PM 33948336
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Wang, GL
   Zhang, YL
   Zhang, RG
   Pan, JL
   Qi, DF
   Wang, J
   Yang, XY
AF Wang, Guoliang
   Zhang, Youlin
   Zhang, Runguang
   Pan, Jianlong
   Qi, Dengfei
   Wang, Jing
   Yang, Xiaoyue
TI The protective effects of walnut green husk polysaccharide on liver
   injury, vascular endothelial dysfunction and disorder of gut microbiota
   in high fructose-induced mice
SO INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
LA English
DT Article
DE Walnut green husk; Polysaccharide; Nonalcoholic fatty liver disease;
   Vascular endothelial dysfunction; Gut microbiota
ID DIET-INDUCED OBESITY; HIGH-FAT; CHEMICAL CHARACTERISTICS;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; ANTIOXIDANT; PEEL; INFLAMMATION;
   POLYPHENOLS; ASSOCIATION
AB This study aimed to investigate the protective effects of walnut green husk polysaccharide (WGHP) on liver injury, vascular endothelial dysfunction and disorder of gut microbiota in mice induced by high fructose (HF) diet. The chemical analysis results show that the walnut green husk polysaccharide is a low molecular weight acidic heteropolysaccharide, composed mainly of glucuronic acid, arabinose and galactose. Biochemical analysis showed that WGHP significantly improved glucose metabolism and lipid metabolism and decreased oxidative stress in HF-diet induced obesity mice. Histopathological observation of liver and cardiovascular aorta confirmed the protective effects of WGHP on hepatic steatosis and vascular endothelial dysfunction. Furthermore, 16S rRNA sequencing results demonstrated that WGHP reversed the disorders of gut microbiota caused by HF, decreased the relative abundance of Verrucomicrobia and increased the relative abundance of Deferribacteres at the phylum level, decreased the relative abundance of Akkermansia, Lachnoclostridium and norank_f__Muribaculaceae and increased the relative abundance of Prevotellaceae_UCG-001, Helicobacter, Alloprevotella and Allobaculum at the genus levels. Our results indicate that WGHP may act as a functional polysaccharide for protecting liver and cardiovascular in HF-fed mice. (c) 2020 Elsevier B.V. All rights reserved.
C1 [Wang, Guoliang; Zhang, Youlin; Zhang, Runguang; Qi, Dengfei; Wang, Jing; Yang, Xiaoyue] Shaanxi Normal Univ, Coll Food Engn & Nutr Sci, Xian 710119, Peoples R China.
   [Pan, Jianlong] Ankang Yingtian Ecol Agr & Forestry Dev Co Ltd, Ankang 725000, Peoples R China.
C3 Shaanxi Normal University
RP Zhang, YL (corresponding author), Shaanxi Normal Univ, Coll Food Engn & Nutr Sci, Xian 710119, Peoples R China.
EM youlinzh@snnu.edu.cn
OI Wang, Guoliang/0000-0002-9685-1840
FU Fundamental Research Funds for the Central Universities [2019TS084];
   Shaanxi Provincial Science and Technology Department
   [2018TSCXL-NY-06-02]; Agriculture Department of Shaanxi Province
   [NYKJ-2018-XA-06]; Shaanxi Province Science and Technology Department
   project [2019NY-133]
FX This work was supported by the Fundamental Research Funds for the
   Central Universities (2019TS084), the Shaanxi Provincial Science and
   Technology Department (2018TSCXL-NY-06-02), the Agriculture Department
   of Shaanxi Province (NYKJ-2018-XA-06) and the Shaanxi Province Science
   and Technology Department project (2019NY-133).
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NR 56
TC 61
Z9 70
U1 7
U2 120
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29a, 1043 NX AMSTERDAM, NETHERLANDS
SN 0141-8130
EI 1879-0003
J9 INT J BIOL MACROMOL
JI Int. J. Biol. Macromol.
PD NOV 1
PY 2020
VL 162
BP 92
EP 106
DI 10.1016/j.ijbiomac.2020.06.055
PG 15
WC Biochemistry & Molecular Biology; Chemistry, Applied; Polymer Science
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry; Polymer Science
GA OA7BQ
UT WOS:000577936100010
PM 32531370
DA 2025-06-11
ER

PT J
AU Esteban, JPG
   Asgharpour, A
AF Esteban, James Philip G.
   Asgharpour, Amon
TI Evaluation of liver transplant candidates with non-alcoholic
   steatohepatitis
SO TRANSLATIONAL GASTROENTEROLOGY AND HEPATOLOGY
LA English
DT Review
DE Non-alcoholic fatty liver disease (NAFLD); non-alcoholic steatohepatitis
   (NASH); end-stage liver disease; cirrhosis; liver transplantation (LT);
   transplant evaluation; cardiac risk assessment
ID CORONARY-ARTERY-DISEASE; ASSOCIATION TASK-FORCE; DOBUTAMINE STRESS
   ECHOCARDIOGRAPHY; NUTRITIONAL PRIORITIZING TOOL; RAPIDLY GROWING
   INDICATION; SEVERE MUSCLE DEPLETION; PORTAL-VEIN THROMBOSIS; LONG-TERM
   OUTCOMES; BODY-MASS INDEX; FATTY LIVER
AB Non-alcoholic steatohepatitis (NASH) is anticipated to become the leading indication for liver transplantation (LT) in the United States in the near future. LT is indicated in patients with NASH-related cirrhosis who have medically refractory hepatic decompensation, synthetic dysfunction, and hepatocellular carcinoma (HCC) meeting certain criteria. The objective of LT evaluation is to determine which patient will derive the most benefit from LT with the least risk, thus maximizing the societal benefits of a limited resource. LT evaluation is a multidisciplinary undertaking involving several specialists, assessment tools, and diagnostic testing. Although the steps involved in LT evaluation are relatively similar across different liver diseases, patients with NASH-related cirrhosis have unique demographic and clinical features that affect transplant outcomes and influence their LT evaluation. LT candidates with NASH should be assessed for metabolic syndrome and obesity, malnutrition and sarcopenia, frailty, and cardiovascular disease. Interventions that treat cardiometabolic co-morbidities and improve patients' nutrition and functionality should be considered in order to improve patient outcomes in the waitlist and after LT.
C1 [Esteban, James Philip G.] Med Coll Wisconsin, Div Gastroenterol & Hepatol, Milwaukee, WI 53226 USA.
   [Esteban, James Philip G.; Asgharpour, Amon] Icahn Sch Med Mt Sinai, Div Liver Dis, New York, NY 10029 USA.
C3 Medical College of Wisconsin; Icahn School of Medicine at Mount Sinai
RP Esteban, JPG (corresponding author), Med Coll Wisconsin, Div Gastroenterol & Hepatol, Milwaukee, WI 53226 USA.
EM jesteban@mcw.edu
RI Esteban, James/ABB-1358-2021
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NR 192
TC 5
Z9 5
U1 0
U2 3
PU AME PUBLISHING COMPANY
PI SHATIN
PA FLAT-RM C 16F, KINGS WING PLAZA 1, NO 3 KWAN ST, SHATIN, HONG KONG
   00000, PEOPLES R CHINA
EI 2415-1289
J9 TRANSL GASTROENT HEP
JI Transl. Gastroenterol. Hepatol.
PD JUL
PY 2022
VL 7
AR 24
DI 10.21037/tgh.2020.03.04
EA FEB 2020
PG 20
WC Gastroenterology & Hepatology
WE Emerging Sources Citation Index (ESCI)
SC Gastroenterology & Hepatology
GA 2F6AB
UT WOS:000675473100001
PM 35892057
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Furuhashi, M
AF Furuhashi, Masato
TI Fatty Acid-Binding Protein 4 in Cardiovascular and Metabolic Diseases
SO JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
LA English
DT Review
DE Adipocyte; Macrophage; Endothelium; Atherosclerosis; Insulin resistance;
   Adipokine; aP2; A-FABP; Mal1; E-FABP
ID ENDOPLASMIC-RETICULUM STRESS; DIFFERENTIATION-INDUCED GENE;
   HORMONE-SENSITIVE LIPASE; ACTIVATED RECEPTOR-GAMMA; ADIPOSE-TISSUE;
   LIPID-ACCUMULATION; PPAR-GAMMA; INFLAMMATORY RESPONSES;
   INSULIN-SECRETION; ENDOTHELIAL-CELLS
AB Fatty acid-binding proteins (FABPs), a family of lipid chaperones, contribute to systemic metabolic regulation via several lipid signaling pathways. Fatty acid-binding protein 4 (FABP4), known as adipocyte FABP (A-FABP) or aP2, is mainly expressed in adipocytes and macrophages and plays important roles in the development of insulin resistance and atherosclerosis in relation to metabolically driven low-grade and chronic inflammation, referred to as 'metaflammation'. FABP4 is secreted from adipocytes in a non-classical pathway associated with lipolysis and acts as an adipokine for the development of insulin resistance and atherosclerosis. Circulating FABP4 levels are associated with several aspects of metabolic syndrome and cardiovascular disease. Ectopic expression and function of FABP4 in cells and tissues are also related to the pathogenesis of several diseases. Pharmacological modification of FABP4 function by specific inhibitors, neutralizing antibodies or antagonists of unidentified receptors would be novel therapeutic strategies for several diseases, including obesity, diabetes mellitus, atherosclerosis and cardiovascular disease. Significant roles of FABP4 as a lipid chaperone in physiological and pathophysiological conditions and the possibility of FABP4 being a therapeutic target for metabolic and cardiovascular diseases are discussed in this review.
C1 [Furuhashi, Masato] Sapporo Med Univ, Sch Med, Dept Cardiovasc Renal & Metab Med, Sapporo, Hokkaido 0608543, Japan.
C3 Sapporo Medical University
RP Furuhashi, M (corresponding author), Sapporo Med Univ, Sch Med, Dept Cardiovasc Renal & Metab Med, Chuo Ku, S-1,W-16, Sapporo, Hokkaido 0608543, Japan.
EM furuhasi@sapmed.ac.jp
RI Furuhashi, Masato/AAT-5518-2021
OI Furuhashi, Masato/0000-0002-0145-3541
FU JSPS KAKENHI; MEXT Translational Research Network Program; Uehara
   Memorial Foundation; SENSHIN Medical Research Foundation; Japan Diabetes
   Foundation; Takeda Medical Research Foundation; Ono Medical Research
   Foundation; Takeda Science Foundation; Akiyama Life Science Foundation;
   Yamaguchi Endocrine Research Foundation; Naito Foundation Natural
   Science Scholarship; Suhara Memorial Foundation; Kondou Kinen Medical
   Foundation; Terumo Foundation for Life Science and Arts; Japan
   Atherosclerosis Society
FX In relation to this review article, M.F. has been supported by grants
   from JSPS KAKENHI, MEXT Translational Research Network Program, Uehara
   Memorial Foundation, SENSHIN Medical Research Foundation, Japan Diabetes
   Foundation, Takeda Medical Research Foundation, Ono Medical Research
   Foundation, Takeda Science Foundation, Akiyama Life Science Foundation,
   Yamaguchi Endocrine Research Foundation, Naito Foundation Natural
   Science Scholarship, Suhara Memorial Foundation, Kondou Kinen Medical
   Foundation and Terumo Foundation for Life Science and Arts. The author
   is grateful to group members of our department for their scientific
   contribution and is deeply honored to receive Yuichiro Goto Award of the
   Japan Atherosclerosis Society in 2018. The author also regrets the
   inadvertent omission of many important references due to space
   limitations.
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NR 170
TC 203
Z9 217
U1 10
U2 61
PU JAPAN ATHEROSCLEROSIS SOC
PI TOKYO
PA NICHINAI-KAIKAN B1, 3-28-8 HONGO BUNKYO-KU, TOKYO, 113-0033, JAPAN
SN 1340-3478
EI 1880-3873
J9 J ATHEROSCLER THROMB
JI J. Atheroscler. Thromb.
PY 2019
VL 26
IS 3
BP 216
EP 232
DI 10.5551/jat.48710
PG 17
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA HN2PG
UT WOS:000460026500002
PM 30726793
OA Green Submitted, gold, Green Published
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Casas, R
   Estruch, R
   Sacanella, E
AF Casas, Rosa
   Estruch, Ramon
   Sacanella, Emilio
TI The Protective Effects of Extra Virgin Olive Oil on Immune-mediated
   Inflammatory Responses
SO ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS
LA English
DT Review
DE Bioactive compounds; inflammatory response; olive oil; phenolic
   compounds; polyphenols; EVOO
ID MONOUNSATURATED FATTY-ACIDS; CARDIOVASCULAR RISK-FACTORS;
   MEDITERRANEAN-STYLE DIET; LOW-DENSITY-LIPOPROTEIN; BREAST-CANCER RISK;
   BLOOD-PRESSURE; METABOLIC SYNDROME; PHENOLIC CONTENT; COLORECTAL-CANCER;
   HEART-DISEASE
AB Background and Objective: The increasing interest in the Mediterranean diet (MeDiet) hinges on the relevant role it plays in inflammatory diseases. Several clinical, epidemiological and experimental evidences suggest that consumption of the MeDiet reduces the incidence of certain pathologies related to oxidative stress, chronic inflammation and immune system diseases such as cancer, atherosclerosis and cardiovascular disease (CVD). These reductions can be partially attributed to extra virgin olive oil (EVOO) consumption which has been described as a key bioactive food because of its high nutritional quality and its particular composition of fatty acids, vitamins and polyphenols. Indeed, the beneficial effects of EVOO have been linked to its fatty acid composition, which is very rich in monounsaturated fatty acids (MUFA), and has moderate saturated and polyunsaturated fatty acids (PUFA). The current knowledge available on the beneficial effects of EVOO and its phenolic compounds, specifically its biological properties and antioxidant capacity against immune-mediated inflammatory responses (atherosclerosis, rheumatoid arthritis, diabetes, obesity, cancer, inflammatory bowel disease or neurodegenerative disease, among others) in addition to its potential clinical applications.
   Conclusion: The increasing body of studies carried out provides compelling evidence that olive polyphenols are potential candidates to combat chronic inflammatory states.
C1 [Casas, Rosa; Estruch, Ramon; Sacanella, Emilio] Univ Barcelona, IDIBAPS, Hosp Clin, Dept Internal Med, Barcelona, Spain.
   [Casas, Rosa; Estruch, Ramon; Sacanella, Emilio] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr 06 03, Madrid, Spain.
C3 University of Barcelona; Hospital Clinic de Barcelona; IDIBAPS;
   Instituto de Salud Carlos III
RP Sacanella, E (corresponding author), Hosp Clin Barcelona, Dept Internal Med, Villarroel 170, Barcelona 08036, Spain.
EM esacane@clinic.ub.es
RI Estruch, Ramon/AAZ-3723-2020; Casas, Rosa/ABD-1915-2020
OI Casas, Rosa/0000-0002-0211-9166
FU Instituto de Salud Carlos III, Spain [PIE14/00045]
FX This work has been partially supported by PIE14/00045 from the Instituto
   de Salud Carlos III, Spain. CIBER OBN is an initiative of the Instituto
   de Salud Carlos III, Spain.
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NR 102
TC 59
Z9 60
U1 1
U2 30
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1871-5303
EI 2212-3873
J9 ENDOCR METAB IMMUNE
JI Endocr. Metab. Immune Disord.-Drug Targets
PY 2018
VL 18
IS 1
BP 23
EP 35
DI 10.2174/1871530317666171114115632
PG 13
WC Endocrinology & Metabolism; Immunology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Immunology; Pharmacology & Pharmacy
GA FU4RL
UT WOS:000423840200005
PM 29141575
DA 2025-06-11
ER

PT J
AU Kanuri, BN
   Kanshana, JS
   Rebello, SC
   Pathak, P
   Gupta, AP
   Gayen, JR
   Jagavelu, K
   Dikshit, M
AF Kanuri, Babu Nageswararao
   Kanshana, Jitendra S.
   Rebello, Sanjay C.
   Pathak, Priya
   Gupta, Anand P.
   Gayen, Jiaur R.
   Jagavelu, Kumaravelu
   Dikshit, Madhu
TI Altered glucose and lipid homeostasis in liver and adipose tissue
   pre-dispose inducible NOS knockout mice to insulin resistance
SO SCIENTIFIC REPORTS
LA English
DT Article
ID NITRIC-OXIDE SYNTHASE; DIET-INDUCED OBESITY; SKELETAL-MUSCLE; METABOLIC
   SYNDROME; MITOCHONDRIAL DYSFUNCTION; RECEPTOR SUBSTRATE-1; TARGETED
   DISRUPTION; OXIDATIVE STRESS; MODEL ASSESSMENT; REACTIVE OXYGEN
AB On the basis of diet induced obesity and KO mice models, nitric oxide is implied to play an important role in the initiation of dyslipidemia induced insulin resistance. However, outcomes using iNOS KO mice have so far remained inconclusive. The present study aimed to assess IR in iNOS KO mice after 5 weeks of LFD feeding by monitoring body composition, energy homeostasis, insulin sensitivity/signaling, nitrite content and gene expressions changes in the tissues. We found that body weight and fat content in KO mice were significantly higher while the respiratory exchange ratio (RER), volume of carbon dioxide (VCO2), and heat production were lower as compared to WT mice. Furthermore, altered systemic glucose tolerance, tissue insulin signaling, hepatic gluconeogenesis, augmented hepatic lipids, adiposity, as well as gene expression regulating lipid synthesis, catabolism and efflux were evident in iNOS KO mice. Significant reduction in eNOS and nNOS gene expression, hepatic and adipose tissue nitrite content, circulatory nitrite was also observed. Oxygen consumption rate of mitochondrial respiration has remained unaltered in KO mice as measured using extracellular flux analyzer. Our findings establish a link between the NO status with systemic and tissue specific IR in iNOS KO mice at 5 weeks.
C1 [Kanuri, Babu Nageswararao; Kanshana, Jitendra S.; Rebello, Sanjay C.; Pathak, Priya; Jagavelu, Kumaravelu] CSIR Cent Drug Res Inst, Pharmacol Div, Lucknow 226031, Uttar Pradesh, India.
   [Kanuri, Babu Nageswararao; Dikshit, Madhu] Acad Sci & Innovat Res, New Delhi 110001, India.
   [Gupta, Anand P.; Gayen, Jiaur R.] CSIR Cent Drug Res Inst, Pharmacokinet & Metab Div, Lucknow 226031, Uttar Pradesh, India.
C3 Council of Scientific & Industrial Research (CSIR) - India; CSIR -
   Central Drug Research Institute (CDRI); Academy of Scientific &
   Innovative Research (AcSIR); Council of Scientific & Industrial Research
   (CSIR) - India; CSIR - Central Drug Research Institute (CDRI)
RP Dikshit, M (corresponding author), Acad Sci & Innovat Res, New Delhi 110001, India.
EM madhu_dikshit@cdri.res
RI Kanshana, Jitendra/AEW-5567-2022; Pathak, Priya/GPC-7456-2022; Jagavelu,
   Kumaravelu/L-8053-2019; KANURI, BABUNAGESWARARAO/AAC-9235-2019
OI KANURI, BABUNAGESWARARAO/0000-0001-8518-9751; Jagavelu,
   Kumaravelu/0000-0002-9235-0600; Pathak, Priya/0000-0002-4150-0058;
   Gayen, Jiaur/0000-0001-7703-9307
FU Council of Scientific and Industrial Research (CSIR) network project
   [BSC0102]; Council of Scientific and Industrial Research (CSIR), New
   Delhi, India; Indian Council of Medical Research, New Delhi, India
FX The study was supported by a financial grant to Madhu Dikshit from
   Council of Scientific and Industrial Research (CSIR) network project
   BSC0102. We gratefully acknowledge the award of research fellowships by
   the Council of Scientific and Industrial Research (CSIR), New Delhi,
   India to K.B.N and Indian Council of Medical Research, New Delhi, India
   to J.S.K. We are grateful to Mr. M.P.S Negi from biometry and statistics
   division, CSIR-CDRI for helping in the statistical analysis of the data.
   The authors are sincerely thankful to Ms. Dipika Awasthi and Ms. Sheela
   Nagarkoti for assistance in conducting experiments. We thank Dr.
   Naibedya Chattopadhyay for providing ECHO-MRI instrument for body
   composition analysis and Mr. Subhashis Pal for excellent help during
   data acquisition and analysis. We acknowledge the scientific and
   technical inputs during this work given by Prof. Parimal Misra (Dr.
   Reddy's Institute of Life Sciences), Dr. S. Sanyal, Dr. A.K. Tamrakar
   and Dr. Sachin Kumar (CSIR-CDRI, Lucknow).
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NR 68
TC 37
Z9 38
U1 0
U2 4
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD JAN 20
PY 2017
VL 7
AR 41009
DI 10.1038/srep41009
PG 13
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA EI3GB
UT WOS:000392376600001
PM 28106120
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Bordoni, A
   Danesi, F
   Dardevet, D
   Dupont, D
   Fernandez, AS
   Gille, D
   dos Santos, CN
   Pinto, P
   Re, R
   Rémond, D
   Shahar, DR
   Vergères, G
AF Bordoni, Alessandra
   Danesi, Francesca
   Dardevet, Dominique
   Dupont, Didier
   Fernandez, Aida S.
   Gille, Doreen
   dos Santos, Claudia Nunes
   Pinto, Paula
   Re, Roberta
   Remond, Didier
   Shahar, Danit R.
   Vergeres, Guy
TI Dairy products and inflammation: A review of the clinical evidence
SO CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
LA English
DT Review
DE Milk; cheese; yoghurt; immune system; chronic diseases; obesity; health
ID LOW-GRADE INFLAMMATION; IN-VITRO DIGESTION; COWS MILK PROTEIN; OXIDATIVE
   STRESS; CARDIOVASCULAR-DISEASE; DIETARY PATTERNS; EOSINOPHILIC
   ESOPHAGITIS; SYSTEMIC INFLAMMATION; METABOLIC SYNDROME; ELIMINATION DIET
AB Inflammation is a major biological process regulating the interaction between organisms and the environment, including the diet. Because of the increase in chronic inflammatory diseases, and in light of the immune-regulatory properties of breastfeeding, the ability of dairy products to modulate inflammatory processes in humans is an important but unresolved issue. Here, we report a systematic review of 52 clinical trials investigating inflammatory markers in relation to the consumption of dairy products. An inflammatory score (IS) was defined to quantitatively evaluate this interaction. The IS was significantly positive for the entire data set, indicating an anti-inflammatory activity in humans. When the subjects were stratified according to their health status, the IS was strongly indicative of an anti-inflammatory activity in subjects with metabolic disorders and of a pro-inflammatory activity in subjects allergic to bovine milk. Stratifying the data by product categories associated both low-fat and high-fat products, as well as fermented products, with an anti-inflammatory activity. Remarkably, the literature is characterized by a large gap in knowledge on bioavailability of bioactive nutrients. Future research should thus better combine food and nutritional sciences to adequately follow the fate of these nutrients along the gastrointestinal and metabolic axes.
C1 [Bordoni, Alessandra; Danesi, Francesca] Univ Bologna, Dept Agrifood Sci & Technol, Bologna, Italy.
   [Dardevet, Dominique; Remond, Didier] CRNH Auvergne, INRA, UMR 1019, UNH, Clermont Ferrand, France.
   [Dardevet, Dominique; Remond, Didier] Univ Auvergne, Clermont Univ, Unite Nutr Humaine, Clermont Ferrand, France.
   [Dupont, Didier] INRA, Joint Res Unit 1253, Sci & Technol Milk & Egg Prod, Rennes, France.
   [Fernandez, Aida S.; Re, Roberta] Leatherhead Food Res, Dept Human Nutr, Leatherhead, Surrey, England.
   [Gille, Doreen; Vergeres, Guy] Agroscope, Fed Dept Econ Affairs Educ & Res EAER, Bern, Switzerland.
   [dos Santos, Claudia Nunes; Pinto, Paula] Univ Nova Lisboa, Inst Tecnol Quim & Biol, Lisbon, Portugal.
   [dos Santos, Claudia Nunes] Insituto Biol Expt & Tecnol, Oeiras, Portugal.
   [Pinto, Paula] Escola Super Agr, Insituto Politecn Santarem, Santarem, Portugal.
   [Shahar, Danit R.] Ben Gurion Univ Negev, Dept Publ Hlth, S Daniel Abraham Int Ctr Hlth & Nutr, Beer Sheva, Israel.
C3 University of Bologna; INRAE; Universite Clermont Auvergne (UCA);
   Universite de Rennes; INRAE; Swiss Federal Research Station Agroscope;
   Universidade Nova de Lisboa; Ben-Gurion University of the Negev
RP Vergères, G (corresponding author), Agroscope, Fed Dept Econ Affairs Educ & Res EAER, Bern, Switzerland.; Vergères, G (corresponding author), CONTACT, Guy Vergeres, Bern, Switzerland.
EM guy.vergeres@agroscope.admin.ch
RI Dupont, Didier/ABA-8197-2020; Vergeres, Guy/HTM-9542-2023; Dardevet,
   Dominique/IAM-3666-2023; Danesi, Francesca/C-1105-2013; Pinto,
   Paula/GSD-4552-2022; Shahar, Danit/B-4280-2012; Bordoni,
   Alessandra/J-3047-2012; DUPONT, Didier/N-8095-2017; Remond,
   Didier/LJL-0035-2024; Nunes dos Santos, Claudia/H-6476-2016
OI Bordoni, Alessandra/0000-0003-4579-1662; DUPONT,
   Didier/0000-0001-5304-6561; Dardevet, Dominique/0000-0001-7320-9970;
   Shahar, Danit Rivka/0000-0003-1000-1819; Danesi,
   Francesca/0000-0002-4134-0066; Remond, Didier/0000-0003-4430-0067; Nunes
   dos Santos, Claudia/0000-0002-5809-1924; Pinto,
   Paula/0000-0001-6379-1768
FU FA COST Action [FA1005]; Fundacao para a Ciencia e Tecnologia
   [PEst-OE/EQB/LA0004/2011, IF/01097/2013]
FX The authors of this review are members of the FA COST Action FA1005
   "Improving health properties of food by sharing our knowledge on the
   digestive process" (INFOGEST) that financed the travel costs for the
   meetings of the MindTheGap project team. This work was, furthermore
   financed by the institutions employing the authors of this report. The
   work of PP and CNS was supported by Fundacao para a Ciencia e Tecnologia
   (PEst-OE/EQB/LA0004/2011 and IF/01097/2013).
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NR 96
TC 166
Z9 180
U1 1
U2 67
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1040-8398
EI 1549-7852
J9 CRIT REV FOOD SCI
JI Crit. Rev. Food Sci. Nutr.
PY 2017
VL 57
IS 12
BP 2497
EP 2525
DI 10.1080/10408398.2014.967385
PG 29
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA ET7WZ
UT WOS:000400511500002
PM 26287637
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Stepanova, M
   Rodriguez, E
   Birerdinc, A
   Baranova, A
AF Stepanova, Maria
   Rodriguez, Edgar
   Birerdinc, Aybike
   Baranova, Ancha
TI Age-independent rise of inflammatory scores may contribute to
   accelerated aging in multi-morbidity
SO ONCOTARGET
LA English
DT Article
DE multi-morbidity; C-reactive protein; systemic inflammation; Glasgow
   Prognostic Score; aging
ID METABOLIC SYNDROME; OXIDATIVE STRESS; DISEASE; OBESITY; MORTALITY;
   POPULATION; BIOMARKERS; LONGEVITY; MARKERS; INDEX
AB Aging is associated with an increase in a chronic, low-grade inflammation. This phenomenon, termed "inflammaging" is also a risk factor for both morbidity and mortality in the elderly. Frequent co-occurrence of chronic diseases, known as multi-morbidity, may be explained by interconnected pathophysiology of these conditions, most of which depend on its inflammatory component. Here we present an analysis of the U.S. National Health and Nutrition Examination Survey data collected between 1999 and 2008, for the presence, and the number, of chronic diseases along with HDL-cholesterol, C-reactive protein, white blood cell count, lymphocyte percent, monocyte percent, segmented neutrophils percent, eosinophils percent, basophils percent, and glycohemoglobin levels. Importantly, even after adjustment for age and BMI, many inflammatory markers continued to be associated to multi-morbidity. C-reactive protein (CRP) levels and Glasgow Prognostic Score (GPS) were most dramatically increased in parallel with an accumulation of chronic diseases, and may be utilized as multi-morbidity predictors. These observations point at background inflammation as direct, age-independent contributor to an accumulation of the disease burden. Our findings also suggest a possibility that systemic inflammation associated with chronic diseases may explain accelerated aging phenomenon previously observed among the patients with heavy disease burden.
C1 [Stepanova, Maria; Rodriguez, Edgar; Birerdinc, Aybike; Baranova, Ancha] George Mason Univ, Sch Syst Biol, Ctr Study Chron Metab Dis, Fairfax, VA 22030 USA.
   [Stepanova, Maria; Birerdinc, Aybike; Baranova, Ancha] Inova Hlth Syst, Betty & Guy Beatty Ctr Integrated Res, Falls Church, VA USA.
   [Baranova, Ancha] Res Ctr Med Genet RAMS, Moscow, Russia.
   [Baranova, Ancha] Atlas Biomed Grp, Moscow, Russia.
C3 George Mason University; Inova Health System; Russian Academy of Medical
   Sciences; Research Centre for Medical Genetics
RP Baranova, A (corresponding author), George Mason Univ, Sch Syst Biol, Ctr Study Chron Metab Dis, Fairfax, VA 22030 USA.
EM abaranov@gmu.edu
RI Stepanova, Maria/V-5513-2019; Baranova, Ancha/B-4608-2012
OI Baranova, Ancha/0000-0001-6810-5982
FU George Mason University
FX There are no competing interests to report. This work was done in
   accordance with the Human Proteome Program by the Federal Agency of
   Scientific Organizations, Russia. Publication of this article was funded
   by the George Mason University Libraries Open Access Publishing Fund.
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NR 31
TC 66
Z9 69
U1 0
U2 6
PU IMPACT JOURNALS LLC
PI ORCHARD PARK
PA 6666 E QUAKER ST, STE 1, ORCHARD PARK, NY 14127 USA
EI 1949-2553
J9 ONCOTARGET
JI Oncotarget
PD JAN 30
PY 2015
VL 6
IS 3
BP 1414
EP 1421
DI 10.18632/oncotarget.2725
PG 8
WC Oncology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Cell Biology
GA CF6TS
UT WOS:000352689800009
PM 25638154
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Masuyama, H
   Nobumoto, E
   Segawa, T
   Hiramatsu, Y
AF Masuyama, Hisashi
   Nobumoto, Etsuko
   Segawa, Tomonori
   Hiramatsu, Yuji
TI Severe Superimposed Preeclampsia with Obesity, Diabetes and a Mild
   Imbalance of Angiogenic Factors
SO ACTA MEDICA OKAYAMA
LA English
DT Article
DE adipocytokine; angiogenic factor; diet therapy; obesity; preeclampsia
ID NORMAL-PREGNANCY; INSULIN-RESISTANCE; HYPOADIPONECTINEMIA; ADIPONECTIN;
   LEPTIN; ADIPOCYTOKINES
AB Preeclampsia may be due to an excess of circulating anti-angiogenic growth factors derived from the placenta, but metabolic syndrome-like disorders may also set off a cascade of placental and systemic inflammation and oxidative stress. We present a case of severe superimposed preeclampsia with obesity, diabetes and a mild imbalance of angiogenic factors, in which diet therapy ameliorated the preeclamptic signs while improving the adiponectin level. A 41-year-old pregnant woman with obesity and diabetes was referred to our hospital because of severe proteinuria and hypertension at 22 weeks of gestation. After administration of insulin and hydralazine with diet therapy, her hypertension and proteinuria were ameliorated with a 15-kg weight loss. Her adiponectin level was low and her leptin level was high, but her angiogenic factor levels were within the normal ranges for pregnant women at admission. The diet therapy ameliorated her hypertension and proteinuria while improving her adiponectin level as she achieved weight loss. This case suggests that diet therapy for obese preeclampsia patients with a mild imbalance of anti-and pro-angiogenic factors may play an important role in managing preeclampsia. Measurements of maternal adipocytokines and angiogenic factors may be important to distinguish the main cause of preeclampsia, i.e., poor placentation or maternal constitutional factors, for managing preeclampsia in patients with obesity.
C1 [Masuyama, Hisashi; Nobumoto, Etsuko; Segawa, Tomonori; Hiramatsu, Yuji] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Obstet & Gynecol, Okayama 7008558, Japan.
C3 Okayama University
RP Masuyama, H (corresponding author), Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Obstet & Gynecol, Okayama 7008558, Japan.
EM masuyama@cc.okayama-u.ac.jp
FU Ministry of Education, Culture, Sports, Science and Technology of Japan
   [22591856]; Grants-in-Aid for Scientific Research [22591856] Funding
   Source: KAKEN
FX This work was supported in part by a research grant from the Ministry of
   Education, Culture, Sports, Science and Technology of Japan (22591856).
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NR 23
TC 9
Z9 9
U1 0
U2 2
PU OKAYAMA UNIV MED SCHOOL
PI OKAYAMA
PA EDITORIAL OFFICE, ACTA MEDICA OKAYAMA OKAYAMA UNIVERSITY MEDICAL SCHOOL
   2-5-1 SHIKATA-CHO, KITA-KU, OKAYAMA, 700-8558, JAPAN
SN 0386-300X
J9 ACTA MED OKAYAMA
JI Acta Med. Okayama
PD APR
PY 2012
VL 66
IS 2
BP 171
EP 175
PG 5
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 930WL
UT WOS:000303175300010
PM 22525475
DA 2025-06-11
ER

PT J
AU Delarue, J
   Magnan, C
AF Delarue, Jacques
   Magnan, Christophe
TI Free fatty acids and insulin resistance
SO CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE
LA English
DT Article
DE acyl-CoA; ceramide; peroxisome; proliferator-activated receptor;
   serine/threonine kinase
ID MAGNETIC-RESONANCE-SPECTROSCOPY; HUMAN SKELETAL-MUSCLE; HUMAN
   ADIPOSE-TISSUE; WEIGHT-LOSS; METABOLIC SYNDROME; GLUCOSE-PRODUCTION;
   HUMAN OBESITY; IN-VIVO; HUMANS; MECHANISMS
AB Purpose of review Dysregulation of free fatty acid metabolism is a key event responsible for insulin resistance and type 2 diabetes. According to the glucose-fatty acid cycle of Randle, preferential oxidation of free fatty acids over glucose plays a major role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. However, other mechanisms are now described to explain the molecular basis of insulin resistance.,
   Recent findings Recent studies have suggested that local accumulation of fat metabolites such as ceramides, diacylglycerol or acyl-CoA, inside skeletal muscle and liver, may activate a serine kinase cascade leading to defects in insulin signalling and glucose transport. Inflammation and oxidative stress are also potent mechanisms which could lead to a state of insulin resistance. Finally, modulation of transcription by free fatty acids through their binding to peroxisome proliferator-activated receptors could also contribute to impaired glucose metabolism.
   Summary The increase in free fatty acid flux resulting from increased lipolysis secondary to adipose-tissue. insulin resistance induces or aggravates insulin resistance in liver and muscle through direct or indirect (from triglyceride deposits) generation of metabolites, altering the insulin signalling pathway. Alleviating the excess of free fatty acids is a target for the treatment of insulin resistance.
C1 CHU Cavale Blanche, Lab Reg Nutr Humaine, F-29200 Brest, France.
   CHU Cavale Blanche, EA 948, F-29200 Brest, France.
   Univ Bretagne Occidentale, Brest, France.
   Univ Paris, F-75252 Paris, France.
C3 CHU Brest; CHU Brest; Universite de Bretagne Occidentale; Universite
   Paris Cite
RP Delarue, J (corresponding author), CHU Cavale Blanche, Lab Reg Nutr Humaine, F-29200 Brest, France.
EM jacques.delarue@univ-brest.fr
RI magnan, christophe/AAJ-7622-2021
OI magnan, christophe/0000-0002-7044-2571
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NR 50
TC 355
Z9 432
U1 0
U2 38
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1363-1950
EI 1473-6519
J9 CURR OPIN CLIN NUTR
JI Curr. Opin. Clin. Nutr. Metab. Care
PD MAR
PY 2007
VL 10
IS 2
BP 142
EP 148
DI 10.1097/MCO.0b013e328042ba90
PG 7
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 142DR
UT WOS:000244629900004
PM 17285001
DA 2025-06-11
ER

PT J
AU Mandal, SK
   Muzaffar-Ur-Rehman, M
   Puri, S
   Kumar, BK
   Sharma, PK
   Sankaranarayanan, M
   Deepa, PR
AF Mandal, Sumit Kumar
   Muzaffar-Ur-Rehman, Mohammed
   Puri, Sonakshi
   Kumar, Banoth Karan
   Sharma, Pankaj Kumar
   Sankaranarayanan, Murugesan
   Deepa, P. R.
TI Unraveling PPARβ/δ nuclear receptor agonists via a
   drug-repurposing approach: HTVS-based ligand identification, molecular
   dynamics, pharmacokinetics, and in vitro anti-steatotic
   validation
SO RSC ADVANCES
LA English
DT Article
ID PROLIFERATOR-ACTIVATED RECEPTOR; CANAGLIFLOZIN
AB Peroxisome proliferator-activated receptors (PPARs) are ligand-activated nuclear receptors with a crucial regulatory role in carbohydrate and lipid metabolism and are emerging druggable targets in "metabolic syndrome" (MetS) and cancers. However, there is a need to identify ligands that can activate specific PPAR subtypes, particularly PPAR beta/delta, which is less studied compared with other PPAR isoforms (alpha and gamma). Herein, using the drug-repurposing approach, the ZINC database of clinically approved drugs was screened to target the PPAR beta/delta receptor through high-throughput-virtual-screening, followed by molecular docking and molecular dynamics (MD) simulation. The top-scoring ligands were subjected to drug-likeness analysis. The hit molecule was tested in an in vitro model of NAFLD (non-alcoholic fatty liver disease). The top five ligands with strong binding affinity towards PPAR beta/delta were canagliflozin > empagliflozin > lumacaftor > eprosartan > dapagliflozin. RMSD/RMSF analysis demonstrated stable protein-ligand complexation (PLC) by the top-scoring ligands with PPAR beta/delta. In silico ADMET prediction analysis revealed favorable pharmacokinetic profiles of these top five ligands. Canagliflozin showed significant (P < 0.001) dose-dependent decrease in lipid accumulation and the associated oxidative stress-inflammatory response, suggesting its promising anti-steatotic potential. These outcomes pave the way for further validation and development of PPAR activity-modulating therapeutics.
C1 [Mandal, Sumit Kumar; Puri, Sonakshi; Sharma, Pankaj Kumar; Deepa, P. R.] Birla Inst Technol & Sci Pilani, Dept Biol Sci, Biochem & Enzyme Biotechnol Lab, Pilani Campus, Pilani 333031, Rajasthan, India.
   [Muzaffar-Ur-Rehman, Mohammed; Kumar, Banoth Karan; Sankaranarayanan, Murugesan] Birla Inst Technol & Sci Pilani, Dept Pharm, Med Chem Res Lab, Pilani Campus, Pilani 333031, Rajasthan, India.
C3 Birla Institute of Technology & Science Pilani (BITS Pilani); Birla
   Institute of Technology & Science Pilani (BITS Pilani)
RP Deepa, PR (corresponding author), Birla Inst Technol & Sci Pilani, Dept Biol Sci, Biochem & Enzyme Biotechnol Lab, Pilani Campus, Pilani 333031, Rajasthan, India.
EM pankajsharma@pilani.bits-pilani.ac.in;
   murugesan@pilani.bits-pilani.ac.in; deepa@pilani.bits-pilani.ac.in
FU Indian Council of Medical Research [52/13/2022-BIO/BMS]; Indian Council
   of Medical Research; BITS Pilani; Ministry of Tribal Affairs, Government
   of India; Department of Biotechnology (Indo-Spain Bilateral Programme)
FX The research grant from the Indian Council of Medical Research
   (52/13/2022-BIO/BMS), Govt. of India, New Delhi, is acknowledged. SKM,
   SP and MMR acknowledged the Institute Fellowship from BITS Pilani, and
   BKK is grateful to the Ministry of Tribal Affairs, Government of India,
   for the research fellowship. SM acknowledges the research support from
   the Department of Biotechnology (Indo-Spain Bilateral Programme), Govt.
   of India, New Delhi.
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NR 45
TC 0
Z9 0
U1 0
U2 0
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
EI 2046-2069
J9 RSC ADV
JI RSC Adv.
PD APR 4
PY 2025
VL 15
IS 14
BP 10622
EP 10633
DI 10.1039/d4ra09055a
PG 12
WC Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry
GA 0YY4W
UT WOS:001459346800001
PM 40190631
OA gold
DA 2025-06-11
ER

PT J
AU Zhang, JL
   Du, BB
   Zhang, DH
   Li, H
   Kong, LY
   Fan, GJ
   Li, YP
   Li, PC
   Liang, C
   Wang, Z
   Yang, LL
   Hao, ZY
   Wu, LM
   Huang, Z
   Dong, JZ
   Zhang, JY
   Yao, R
   Wang, SJ
   Zhang, YZ
AF Zhang, Jie-Lei
   Du, Bin-Bin
   Zhang, Dian-Hong
   Li, Huan
   Kong, Ling-Yao
   Fan, Guang-Jian
   Li, Ya-Peng
   Li, Peng-Cheng
   Liang, Cui
   Wang, Zheng
   Yang, Lu-Lu
   Hao, Zheng-Yang
   Wu, Lei-Ming
   Huang, Zhen
   Dong, Jian-Zeng
   Zhang, Jin-Ying
   Yao, Rui
   Wang, Shou-Jun
   Zhang, Yan-Zhou
TI OTUB1 alleviates NASH through inhibition of the TRAF6-ASK1 signaling
   pathways
SO HEPATOLOGY
LA English
DT Article
ID FATTY LIVER-DISEASE; DEPENDENT ACTIVATION; OXIDATIVE STRESS;
   PATHOGENESIS; UBIQUITINATION; DEGRADATION; SPECIFICITY; PROTECTS;
   DAMAGE; GAMMA
AB Background and Aims NAFLD is considered as the hepatic manifestation of the metabolic syndrome, which includes insulin resistance, obesity and hyperlipidemia. NASH is a progressive stage of NAFLD with severe hepatic steatosis, hepatocyte death, inflammation, and fibrosis. Currently, no pharmacological interventions specifically tailored for NASH are approved. Ovarian tumor domain, ubiquitin aldehyde binding 1 (OTUB1), the founding member of deubiquitinases, regulates many metabolism-associated signaling pathways. However, the role of OTUB1 in NASH is unclarified. Methods and Results We demonstrated that mice with Otub1 deficiency exhibited aggravated high-fat diet-induced and high-fat high-cholesterol (HFHC) diet-induced hyperinsulinemia and liver steatosis. Notably, hepatocyte-specific overexpression of Otub1 markedly alleviated HFHC diet-induced hepatic steatosis, inflammatory responses, and liver fibrosis. Mechanistically, we identified apoptosis signal-regulating kinase 1 (ASK1) as a key candidate target of OTUB1 through RNA-sequencing analysis and immunoblot analysis. Through immunoprecipitation-mass spectrometry analysis, we further found that OTUB1 directly bound to tumor necrosis factor receptor-associated factor 6 (TRAF6) and suppressed its lysine 63-linked polyubiquitination, thus inhibiting the activation of ASK1 and its downstream pathway. Conclusion OTUB1 is a key suppressor of NASH that inhibits polyubiquitinations of TRAF6 and attenuated TRAF6-mediated ASK1 activation. Targeting the OTUB1-TRAF6-ASK1 axis may be a promising therapeutic strategy for NASH.
C1 [Zhang, Jie-Lei; Wang, Shou-Jun] Zhengzhou Univ, Dept Endocrinol, Affiliated Hosp 1, 1 Jianshe East Rd, Zhengzhou 450052, Henan, Peoples R China.
   [Du, Bin-Bin; Zhang, Dian-Hong; Li, Huan; Kong, Ling-Yao; Li, Ya-Peng; Li, Peng-Cheng; Liang, Cui; Wang, Zheng; Yang, Lu-Lu; Hao, Zheng-Yang; Wu, Lei-Ming; Huang, Zhen; Dong, Jian-Zeng; Zhang, Jin-Ying; Yao, Rui; Zhang, Yan-Zhou] Zhengzhou Univ, Cardiovasc Hosp, Affiliated Hosp 1, 1 Jianshe East Rd, Zhengzhou 450052, Henan, Peoples R China.
   [Fan, Guang-Jian] Shanghai Jiao Tong Univ, Shanghai Gen Hosp, Precis Res Ctr Refractory Dis, Inst Clin Res,Sch Med, Shanghai, Peoples R China.
C3 Zhengzhou University; Zhengzhou University; Shanghai Jiao Tong
   University
RP Wang, SJ (corresponding author), Zhengzhou Univ, Dept Endocrinol, Affiliated Hosp 1, 1 Jianshe East Rd, Zhengzhou 450052, Henan, Peoples R China.; Yao, R; Zhang, YZ (corresponding author), Zhengzhou Univ, Cardiovasc Hosp, Affiliated Hosp 1, 1 Jianshe East Rd, Zhengzhou 450052, Henan, Peoples R China.
EM yryaorui@163.com; wangshoujun02@126.com; zhangyanzhou2050@sina.com
RI LI, Yapeng/GPF-6881-2022; Wu, Leiming/HJP-1511-2023; liang,
   cui/KIE-2680-2024
FU National Natural Science Foundation of China [81970242, 82000826];
   Cooperative Project of Academy Training Foundation of Zhengzhou
   University [2016-BSTDJJ-13]; Medical Science and Technology Program of
   Henan Province [LHGJ20200344, LHGJ20200335, LHGJ20190261, SBGJ202002044,
   SBGJ 202003046]
FX National Natural Science Foundation of China (81970242 and 82000826);
   Cooperative Project of Academy Training Foundation of Zhengzhou
   University (2016-BSTDJJ-13); Medical Science and Technology Program of
   Henan Province (LHGJ20200344, LHGJ20200335, LHGJ20190261, SBGJ202002044,
   and SBGJ 202003046)
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NR 47
TC 24
Z9 26
U1 1
U2 55
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0270-9139
EI 1527-3350
J9 HEPATOLOGY
JI Hepatology
PD MAY
PY 2022
VL 75
IS 5
BP 1218
EP 1234
DI 10.1002/hep.32179
EA DEC 2021
PG 17
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 0T5OH
UT WOS:000727579400001
PM 34591986
DA 2025-06-11
ER

PT J
AU Zhu, ML
   Chen, HQ
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   Li, X
   Chu, RX
   Chen, W
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AF Zhu, Meilin
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   Wang, Meng
   Chai, Zhifang
   Feng, Weiyue
TI Iron oxide nanoparticles aggravate hepatic steatosis and liver injury in
   nonalcoholic fatty liver disease through BMP-SMAD-mediated hepatic iron
   overload
SO NANOTOXICOLOGY
LA English
DT Article
DE Iron oxide nanoparticles; NAFLD; hepatic iron overload; BMP-SMAD;
   hepatic steatosis
ID LIPID-METABOLISM; CONTRAST AGENT; EXPRESSION; STEATOHEPATITIS;
   HOMEOSTASIS; FIBROSIS; STRESS
AB Nonalcoholic fatty liver disease (NAFLD) is the leading hepatic manifestation of metabolic syndrome worldwide, and is clinically accompanied by iron overload. As the increasing application of iron oxide nanoparticles (IONPs) on the imaging and diagnosis in NAFLD, the potential hepatic effect and mechanism of IONPs on NAFLD should be well studied. Here, we demonstrate that carboxyl-modified (COOH-IONPs) and amino-coated IONPs (NH2-IONPs) exhibit no significant hepatic toxicity in normal mice at the clinical injection dose, but aggravate SREBP-1c-mediated de novo lipogenesis (DNL) in the livers of mice with NAFLD induced by high-fat diet (HFD) and in HepG2 cells incubated with oleic acid (OA), especially in those treated by the positive NH2-IONPs. In the present study, mice receiving IONPs for 7 day show mild iron overload in the liver and exhibit enhanced hepatic inflammation in NAFLD. The BMP-SMAD pathway is initiated by hepatic iron overload and is aggravated in NAFLD. In conclusion, BMP-SMAD-mediated hepatic iron overload aggravated lipid accumulation in the liver and hepatic inflammatory responses, implying that effective measures in addition to hepatic iron overload are needed for individuals at the risk of IONPs in NAFLD.
C1 [Zhu, Meilin; Zhou, Shuang; Zheng, Lingna; Li, Xue; Chu, Runxuan; Chen, Wei; Wang, Bing; Wang, Meng; Chai, Zhifang; Feng, Weiyue] Chinese Acad Sci, Inst High Energy Phys, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing, Peoples R China.
   [Zhu, Meilin] Anhui Univ, Inst Phys Sci & Informat Technol, Hefei, Peoples R China.
   [Chen, Hanqing] South China Univ Technol, Guangzhou Peoples Hosp 1, Guangzhou Digest Dis Ctr, Dept Gastroenterol,Sch Med, Guangzhou, Peoples R China.
   [Zhou, Shuang; Chen, Wei] Univ Chinese Acad Sci, Beijing, Peoples R China.
   [Chai, Zhifang] Soochow Univ, Sch Radiol & Interdisciplinary Sci RAD X, State Key Lab Radiat Med & Protect, Suzhou, Peoples R China.
C3 Chinese Academy of Sciences; Key Laboratory for Biological Effects of
   Nanomaterials & Nanosafety, CAS; Institute of High Energy Physics, CAS;
   Anhui University; South China University of Technology; Chinese Academy
   of Sciences; University of Chinese Academy of Sciences, CAS; Soochow
   University - China
RP Feng, WY (corresponding author), Chinese Acad Sci, Inst High Energy Phys, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing, Peoples R China.; Chen, HQ (corresponding author), South China Univ Technol, Guangzhou Peoples Hosp 1, Guangzhou Digest Dis Ctr, Dept Gastroenterol,Sch Med, Guangzhou, Peoples R China.
EM eyhanqingchen@scut.edu.cn; fengwy@ihep.ac.cn
RI Chen, Hanqing/GLN-5182-2022; Li, Xue/GWR-0863-2022; Zheng,
   Lingna/C-2494-2015; Feng, Wei-Yue/H-3390-2016; WANG, Meng/KLZ-1593-2024
OI WANG, Meng/0000-0002-4970-8590; Chu, Runxuan/0009-0007-9641-2761; Chen,
   Hanqing/0000-0001-5442-2071
FU National Basic Research Program [2016YFA0201603]; National Natural
   Science Foundation of China [11775234, 11975251, 11875268]; Open Project
   of Key Laboratory of Nanobiological Effects and Safety, CAS
   [NSKF202007]; Research Foundation of Guangzhou First People's Hospital
   [KY09040029]
FX This work was supported by the National Basic Research Program [Grant
   no. 2016YFA0201603], the National Natural Science Foundation of China
   [Grant nos. 11775234, 11975251, and 11875268], the Open Project of Key
   Laboratory of Nanobiological Effects and Safety, CAS (No. NSKF202007),
   and Research Foundation of Guangzhou First People's Hospital (No.
   KY09040029).
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NR 49
TC 21
Z9 23
U1 0
U2 35
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1743-5390
EI 1743-5404
J9 NANOTOXICOLOGY
JI Nanotoxicology
PD JUL 3
PY 2021
VL 15
IS 6
BP 761
EP 778
DI 10.1080/17435390.2021.1919329
EA MAY 2021
PG 18
WC Nanoscience & Nanotechnology; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics; Toxicology
GA TZ0OR
UT WOS:000648179300001
PM 33961538
DA 2025-06-11
ER

PT J
AU Ruiz-Ojeda, FJ
   Anguita-Ruiz, A
   Rupérez, A
   Gomez-Llorente, C
   Olza, J
   Vázquez-Cobela, R
   Gil-Campos, M
   Bueno, G
   Leis, R
   Cañete, R
   Moreno, LA
   Gil, A
   Aguilera, CM
AF Ruiz-Ojeda, Francisco Javier
   Anguita-Ruiz, Augusto
   Ruperez, Azahara, I
   Gomez-Llorente, Carolina
   Olza, Josune
   Vazquez-Cobela, Rocio
   Gil-Campos, Mercedes
   Bueno, Gloria
   Leis, Rosaura
   Canete, Ramon
   Moreno, Luis A.
   Gil, Angel
   Maria Aguilera, Concepcion
TI Effects of X-chromosome Tenomodulin Genetic Variants on Obesity in a
   Children's Cohort and Implications of the Gene in Adipocyte Metabolism
SO SCIENTIFIC REPORTS
LA English
DT Article
ID INSULIN-RESISTANCE; ADIPOSE-TISSUE; OXIDATIVE STRESS; EXPRESSION;
   ASSOCIATION; INACTIVATION; DIFFERENTIATION; INFLAMMATION; ANGIOGENESIS;
   LANDSCAPE
AB Tenomodulin (TNMD) is a type II transmembrane glycoprotein that has been recently linked to obesity, and it is highly expressed in obese adipose tissue. Several sex-dependent associations have been observed between single-nucleotide polymorphisms (SNPs) of the TNMD gene, which is located in the X-chromosome, and obesity, type 2 diabetes mellitus (T2DM), and metabolic syndrome in adults. On the other hand, results are lacking for children. We aimed (i) to study the association between TNMD genetic variants and metabolic complications related to childhood obesity and (ii) to investigate the function of TNMD in human adipocytes. We conducted a case-control, multicenter study in 915 Spanish children and demonstrated significant positive associations between TNMD genetic variants and BMI z-score, waist circumference, fasting glucose, and insulin resistance in boys, highlighting the SNP rs4828038. Additionally, we showed a BMI-adjusted inverse association with waist circumference in girls. Second, in vitro experiments revealed that TNMD is involved in adipogenesis, along with glucose and lipid metabolism in differentiated adipocytes, and these effects may be mediated through AMPK activation. Hence, these results suggest that TNMD genetic variants could be potentially useful as early life risk indicators for obesity and T2DM. In addition, we support the fact that TNMD exhibits significant metabolic functions in adipocytes.
C1 [Ruiz-Ojeda, Francisco Javier; Anguita-Ruiz, Augusto; Ruperez, Azahara, I; Gomez-Llorente, Carolina; Olza, Josune; Gil, Angel; Maria Aguilera, Concepcion] Univ Granada, Ctr Biomed Res, Inst Nutr & Food Technol Jose Mataix, Dept Biochem & Mol Biol 2, Avda Conocimiento S-N, Granada 18016, Spain.
   [Ruiz-Ojeda, Francisco Javier; Anguita-Ruiz, Augusto; Gomez-Llorente, Carolina; Olza, Josune; Gil, Angel; Maria Aguilera, Concepcion] Complejo Hosp Univ Granada, Inst Invest Biosanitaria IBSGRANADA, Granada 18014, Spain.
   [Anguita-Ruiz, Augusto; Gomez-Llorente, Carolina; Olza, Josune; Gil-Campos, Mercedes; Bueno, Gloria; Leis, Rosaura; Canete, Ramon; Moreno, Luis A.; Gil, Angel; Maria Aguilera, Concepcion] ISCIII, Spanish Biomed Res Ctr Physiopathol Obes & Nutr C, Madrid 28029, Spain.
   [Vazquez-Cobela, Rocio; Leis, Rosaura] Complexo Hosp Univ Santiago, Inst Invest Sanitaria Santiago de Compostela IDIS, Pediat Dept USC, Unit Invest Nutr Growth & Human Dev Galicia, Santiago De Compostela, Spain.
   [Ruperez, Azahara, I; Bueno, Gloria; Moreno, Luis A.] Univ Zaragoza, Growth Exercise NUtr & Dev GENUD Res Grp, Zaragoza, Spain.
   [Bueno, Gloria; Moreno, Luis A.] IIS Aragon, IA2, Zaragoza, Spain.
   [Gil-Campos, Mercedes; Canete, Ramon] Univ Cordoba, Inst Maimonides Biomed Invest Cordoba IMIBIC, Reina Sofia Univ Hosp, Dept Paediat, Avda Menendez Pidal S-N, E-14004 Cordoba, Spain.
C3 University of Granada; University of Granada; Instituto de Investigacion
   Biosanitaria IBS Granada; Instituto de Salud Carlos III; Complexo
   Hospitalario Universitario de Santiago de Compostela; University of
   Zaragoza; Universidad de Cordoba
RP Ruiz-Ojeda, FJ; Aguilera, CM (corresponding author), Univ Granada, Ctr Biomed Res, Inst Nutr & Food Technol Jose Mataix, Dept Biochem & Mol Biol 2, Avda Conocimiento S-N, Granada 18016, Spain.; Ruiz-Ojeda, FJ; Aguilera, CM (corresponding author), Complejo Hosp Univ Granada, Inst Invest Biosanitaria IBSGRANADA, Granada 18014, Spain.; Aguilera, CM (corresponding author), ISCIII, Spanish Biomed Res Ctr Physiopathol Obes & Nutr C, Madrid 28029, Spain.
EM fruizojeda@ugr.es; caguiler@ugr.es
RI Olza, Josune/Y-3333-2019; BUENO, Maria/AAG-9985-2021; Leis,
   Rosaura/Z-3186-2019; Rupérez, Azahara/L-3771-2019; Anguita-Ruiz,
   Augusto/AAE-9827-2019; Moreno, Luis/S-1780-2019; Aguilera,
   Concepcion/M-1663-2014; Ruiz Ojeda, Francisco Javier/D-1228-2016; Olza,
   Josune/N-7718-2013; Gil, Angel/L-2275-2014; Gomez Llorente,
   Carolina/K-7484-2015; Vazquez Cobela, Rocio/ABF-5488-2020; Anguita-Ruiz,
   Augusto/X-7448-2018
OI Leis, Rosaura/0000-0002-0540-4210; Ruperez, Azahara
   I./0000-0002-3850-8235; Ruiz Ojeda, Francisco
   Javier/0000-0002-4452-0855; Olza, Josune/0000-0001-8840-8542; Gil,
   Angel/0000-0001-7663-0939; Gil-Campos, Mercedes/0000-0002-9007-0242;
   Gomez Llorente, Carolina/0000-0003-3948-1473; Vazquez Cobela,
   Rocio/0000-0002-3155-1601; Moreno Aznar, Luis A./0000-0003-0454-653X;
   Anguita-Ruiz, Augusto/0000-0001-6888-1041
FU Plan Nacional de Investigacion Cientifica, Desarrollo e Innovacion
   Tecnologica (I + D + I), Instituto de Salud Carlos III-Fondo de
   Investigacion Sanitaria [PI020826, PI051968, PI1102042, PI1600871];
   Junta de Andalucia [CTS-6770]; Secretaria General de Universidades,
   Investigacion y Tecnologia. Consejeria de Economia, Innovacion y
   Ciencia; RETIC [Red SAMID RD12/0026/0015]; Fondo Europeo De Desarrollo
   Regional (FEDER)
FX This work was supported by Plan Nacional de Investigacion Cientifica,
   Desarrollo e Innovacion Tecnologica (I + D + I), Instituto de Salud
   Carlos III-Fondo de Investigacion Sanitaria (Projects numbers PI020826,
   PI051968, PI1102042, PI1600871), RETIC (Red SAMID RD12/0026/0015), Fondo
   Europeo De Desarrollo Regional (FEDER) and the Junta de Andalucia
   (project number CTS-6770); Secretaria General de Universidades,
   Investigacion y Tecnologia. Consejeria de Economia, Innovacion y
   Ciencia). The funders had no role in study design, data collection and
   analysis, decision to publish, or preparation of the manuscript. This
   paper will be part of Augusto Anguita-Ruiz's doctorate, which is being
   performed under the "Nutrition and Food Sciences Program" at the
   University of Granada.
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NR 83
TC 8
Z9 8
U1 0
U2 3
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD MAR 8
PY 2019
VL 9
AR 3979
DI 10.1038/s41598-019-40482-0
PG 16
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA HO0WZ
UT WOS:000460627700067
PM 30850679
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Utkan, T
   Yazir, Y
   Karson, A
   Bayramgürler, D
AF Utkan, Tijen
   Yazir, Yusufhan
   Karson, Ayse
   Bayramgurler, Dilek
TI Etanercept Improves Cognitive Performance and Increases eNOS and BDNF
   Expression During Experimental Vascular Dementia in
   Streptozotocin-induced Diabetes
SO CURRENT NEUROVASCULAR RESEARCH
LA English
DT Article
DE Diabetes mellitus; learning; memory; water maze; passive avoidance; rat
ID HIPPOCAMPAL SYNAPTIC PLASTICITY; FACTOR-ALPHA TREATMENT; CHRONIC MILD
   STRESS; ENDOTHELIAL DYSFUNCTION; METABOLIC SYNDROME; RATS; IMPAIRMENT;
   PREVENTS; MEMORY; MODEL
AB Diabetes mellitus (DM) is related to an increase in the incidence of vascular dementia. Inflammation is an important cause of endothelial dysfunction and cognitive deficits. The anti -tumor necrosis factor (TNF)-alpha fusion protein etanercept has been reported to exhibit memory-enhancing effects and endothelial protection. We tested the effect of etanercept on the cognitive endpoints and compared it with the cognitive dysfunction in streptozotocin (STZ)-induced DM rats by using the Morris water maze test (MWMT) and passive avoidance test (PAT). Systolic blood pressure (SBP), thoracic endothelial function, endothelial nitric oxide synthase (eNOS) expression, and hippocampal brain-derived neurotrophic factor (BDNF) expression were assessed. Thirty days after the induction of DM, rats exhibited severe learning and memory deficits associated with endothelial dysfunction and decreased expression of eNOS and BDNF. Chronic treatment with etanercept (0.8 mg/kg, s.c., every week for 30 days) improved cognitive performance, endothelial function, and expression of eNOS and BDNF in DM rats. Furthermore, the memory-improving effects of etanercept were independent of hyperglycemia. These data suggest that etanercept treatment prevents changes in endothelial function, eNOS expression, and hippocampal expression of BDNF and, consequently, vascular dementia in DM rats.
C1 [Utkan, Tijen] Kocaeli Univ, Fac Med, Dept Pharmacol, Kocaeli, Turkey.
   [Utkan, Tijen] Kocaeli Univ, Expt Med Res & Applicat Ctr, Kocaeli, Turkey.
   [Yazir, Yusufhan] Kocaeli Univ, Fac Med, Dept Histol & Emryol, Kocaeli, Turkey.
   [Karson, Ayse] Kocaeli Univ, Fac Med, Dept Physiol, Kocaeli, Turkey.
   [Bayramgurler, Dilek] Kocaeli Univ, Fac Med, Dept Dermatol, Kocaeli, Turkey.
C3 Kocaeli University; Kocaeli University; Kocaeli University; Kocaeli
   University; Kocaeli University
RP Utkan, T (corresponding author), Kocaeli Univ, Expt Med Res & Applicat Ctr, Kocaeli, Turkey.
EM tijenutkan@hotmail.com
RI Yazır, YUSUFHAN/F-7289-2018; Utkan, Tijen/G-2398-2018; bayramgürler,
   Dilek/AAD-1184-2020
OI utkan, tijen/0000-0001-5848-3680; Yazir, Yusufhan/0000-0002-8472-0261;
   Karson, Ayse/0000-0003-4909-4012
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NR 60
TC 25
Z9 29
U1 0
U2 7
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1567-2026
EI 1875-5739
J9 CURR NEUROVASC RES
JI Curr. Neurovasc. Res.
PY 2015
VL 12
IS 2
BP 135
EP 146
DI 10.2174/1567202612666150311111340
PG 12
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA CE5JD
UT WOS:000351867500005
PM 25760219
DA 2025-06-11
ER

PT J
AU Bahadoran, Z
   Mirmiran, P
   Yeganeh, MZ
   Hosseinpanah, F
   Zojaji, H
   Azizi, F
AF Bahadoran, Zahra
   Mirmiran, Parvin
   Yeganeh, Maryam Zarif
   Hosseinpanah, Farhad
   Zojaji, Homayoun
   Azizi, Fereidoun
TI Complementary and alternative medicinal effects of broccoli sprouts
   powder on Helicobacter pylori eradication rate in type 2 diabetic
   patients: A randomized clinical trial
SO JOURNAL OF FUNCTIONAL FOODS
LA English
DT Article
DE Helicobacter pylori; Standard triple therapy; Broccoli sprouts powder;
   Gastric inflammation; Insulin resistance
ID INSULIN-RESISTANCE; SERUM PEPSINOGENS; JAPANESE POPULATION; ATROPHIC
   GASTRITIS; METABOLIC SYNDROME; OXIDATIVE STRESS; INFECTION;
   SULFORAPHANE; ASSOCIATION; COMPLICATIONS
AB The effectiveness of high-sulforaphane broccoli sprouts powder, as both complementary and alternative treatment, was compared to the standard triple therapy on Helicobacter pylori eradication in type 2 diabetic patients. Eighty-six type 2 diabetic patients with positive H. pylori stool antigen test (HpSAg) were randomized to receive one of the three following regimens: (STT) standard triple therapy, (BSP) 6 g/d broccoli sprouts powder for 28 days, and combination of these as STT + BSP. H. pylori eradication rates were assessed both by HpSAg and the urea breath test (UBT). Fasting serum glucose, insulin, insulin resistance, pepsinogen (PG) I and II levels and PGI/II ratio were also assessed. The H. pylori eradication rates, as assessed by UBT and HpSAg, were 85.3% and 89.3% in STT, 36.0% and 56.0% in BSP, and 83.3% and 91.7% in STT + BSP groups, respectively. There were no significant differences in serum pepsinogen I, pepsinogen II and PGI/PGII ratio and glucose homeostasis parameters between the three groups. BSP regimen despite a considerable effect on H. pylori eradication could not compete with the standard triple therapy. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Bahadoran, Zahra; Yeganeh, Maryam Zarif] Shahid Beheshti Univ Med Sci, Res Inst Endocrine Sci, Nut & Endocrine Res Ctr, Tehran, Iran.
   [Bahadoran, Zahra; Yeganeh, Maryam Zarif; Hosseinpanah, Farhad] Shahid Beheshti Univ Med Sci, Res Inst Endocrine Sci, Obes Res Ctr, Tehran, Iran.
   [Mirmiran, Parvin] Shahid Beheshti Univ Med Sci, Natl Nutr & Food Technol Res Inst, Fac Nutr Sci & Food Technol, Dept Clin Nutr & Dietet, Tehran, Iran.
   [Zojaji, Homayoun] Shahid Beheshti Univ Med Sci, Dept Gastroenterol & Liver Dis, Res Ctr Gastroenterol & Liver Dis, Tehran, Iran.
   [Azizi, Fereidoun] Shahid Beheshti Univ Med Sci, Res Inst Endocrine Sci, Endocrine Res Ctr, Tehran, Iran.
C3 Shahid Beheshti University Medical Sciences; Shahid Beheshti University
   Medical Sciences; Shahid Beheshti University Medical Sciences; Shahid
   Beheshti University Medical Sciences; Shahid Beheshti University Medical
   Sciences
RP Mirmiran, P (corresponding author), 46 Arghavan Ee Ggharbi St,POB 19395-4741, Tehran, Iran.
EM mirmiran@endocrine.ac.ir
RI hosseinpanah, farhad/AAM-7277-2020; Bahadoran, Zahra/V-2003-2019;
   Mirmiran, Parvin/V-1433-2019; Azizi, Fereidoun/ABD-4136-2021
OI Azizi, Fereidoun/0000-0002-6470-2517; Mirmiran,
   Parvin/0000-0003-2391-4924
FU Research Institute of Endocrine Sciences, Shahid Beheshti University of
   Medical Sciences, Tehran, Iran
FX This study was funded by the Research Institute of Endocrine Sciences,
   Shahid Beheshti University of Medical Sciences, Tehran, Iran. The
   authors express appreciation to the participants of this study. The
   authors wish to thank Ms. N. Shiva for critical editing of English
   grammar and syntax. The project was designed and implemented by Z.B and
   P.M. Patients recruitment and intervention were performed by Z.B, M.Z.Y,
   and H.Z. The data were analyzed and interpreted by Z.B. The manuscript
   was prepared by Z.B, P.M, F.H, H.Z, and F.A. P.M and EA supervised
   overall project and approved the final version of the manuscript for
   submission. All authors of the paper have no conflict of interest.
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NR 40
TC 15
Z9 16
U1 0
U2 29
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1756-4646
J9 J FUNCT FOODS
JI J. Funct. Food.
PD MAR
PY 2014
VL 7
BP 390
EP 397
DI 10.1016/j.jff.2014.01.020
PG 8
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA AG1VE
UT WOS:000335203500039
DA 2025-06-11
ER

PT J
AU Hafstad, AD
   Lund, J
   Hadler-Olsen, E
   Höper, AC
   Larsen, TS
   Aasum, E
AF Hafstad, Anne D.
   Lund, Jim
   Hadler-Olsen, Elin
   Hoper, Anje C.
   Larsen, Terje S.
   Aasum, Ellen
TI High- and Moderate-Intensity Training Normalizes Ventricular Function
   and Mechanoenergetics hi Mice With Diet-Induced Obesity
SO DIABETES
LA English
DT Article
ID CARDIAC EFFICIENCY; OXYGEN-CONSUMPTION; CARDIOMYOCYTE CONTRACTILITY;
   EXERCISE INTENSITY; METABOLIC SYNDROME; ANGIOTENSIN-II; HEART; CAPACITY;
   ACID; RISK
AB Although exercise reduces several cardiovascular risk factors associated with obesity/diabetes, the metabolic effects of exercise on the heart are not well-known. This study was designed to investigate whether high-intensity interval training (HIT) is superior to moderate-intensity training (MIT) in counteracting obesity-induced impairment of left ventricular (LV) mechanoenergetics and function. C57BL/6J mice with diet-induced obesity (DIO mice) displaying a cardiac phenotype with altered substrate utilization and impaired mechanoenergetics were subjected to a sedentary lifestyle or 8-10 weeks of isocaloric HIT or MIT. Although both modes of exercise equally improved aerobic capacity and reduced obesity, only HIT improved glucose tolerance. Hearts from sedentary DIO mice developed concentric LV remodeling with diastolic and systolic dysfunction, which was prevented by both HET and MIT. Both modes of exercise also normalized LV mechanical efficiency and mechanoenergetics. These changes were associated with altered myocardial substrate utilization and improved mitochondrial capacity and efficiency, as well as reduced oxidative stress, fibrosis, and intracellular matrix metolloproteinase 2 content. As both modes of exercise equally ameliorated the development of diabetic cardiomyopathy by preventing LV remodeling and mechanoenergetic impairment, this study advocates the therapeutic potential of physical activity in obesity-related cardiac disorders.
C1 [Hafstad, Anne D.; Lund, Jim; Hoper, Anje C.; Larsen, Terje S.; Aasum, Ellen] Univ Tromso, Dept Med Biol, Fac Hlth Sci, Cardiovasc Res Grp, Tromso, Norway.
   [Hadler-Olsen, Elin] Univ Tromso, Dept Med Biol, Tumor Biol Res Grp, Fac Hlth Sci, Tromso, Norway.
C3 UiT The Arctic University of Tromso; UiT The Arctic University of Tromso
RP Hafstad, AD (corresponding author), Univ Tromso, Dept Med Biol, Fac Hlth Sci, Cardiovasc Res Grp, Tromso, Norway.
EM anne.hafstad@uit.no
RI Hafstad, Anne/AAK-4269-2021; Höper, Anje Christina/KHU-4443-2024;
   Hadler-Olsen, Elin/AAL-7288-2020
OI Hafstad, Anne/0000-0003-0711-9736; Hoper, Anje
   Christina/0000-0002-8962-5853; Hadler-Olsen, Elin/0000-0001-8476-9439
FU Norwegian Research Council; Northern Norway Regional Health Authority
   (Helse Nord RHF, UNIKARD); Norwegian Health Association
FX This work was supported by the Norwegian Research Council and the
   Northern Norway Regional Health Authority (Helse Nord RHF, UNIKARD), as
   well as by the Norwegian Health Association.
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NR 50
TC 88
Z9 106
U1 0
U2 26
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0012-1797
EI 1939-327X
J9 DIABETES
JI Diabetes
PD JUL
PY 2013
VL 62
IS 7
BP 2287
EP 2294
DI 10.2337/db12-1580
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 173KA
UT WOS:000321077200018
PM 23493573
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Lee, MS
   Hang, JQ
   Zhang, FY
   Zheng, BY
   Su, L
   Zhao, Y
   Dai, HL
   Zhang, HX
   Christiani, DC
AF Lee, Mi-Sun
   Hang, Jing-qing
   Zhang, Feng-ying
   Zheng, Bu-yong
   Su, Li
   Zhao, Yang
   Dai, He-lian
   Zhang, Hong-xi
   Christiani, David C.
TI Household solid fuel use and pulmonary function in an urban population
   in Shanghai, China
SO OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
LA English
DT Article
ID INDOOR AIR-POLLUTION; LUNG-CANCER; OXIDATIVE STRESS; METABOLIC SYNDROME;
   RISK; EXPOSURE; INFLAMMATION; PARTICLES; SMOKING; DISEASE
AB Objectives We examined the association between household solid fuel exposure and lung function in a densely populated district in urban Shanghai, China.
   Methods Spirometry was performed in 12 506 subjects, aged 18 and over, residing in the Putuo District in Shanghai, China, in a cross-sectional survey. Exposure to solid fuel use at home was assessed by an administered questionnaire, estimating duration and total amount of solid fuel use at home during the lifetime.
   Results After adjusting for confounders, the subjects with exposure to household solid fuel had a 1.3% (95% CI 0.57 to 2.02) decrease in forced expiratory volume in 1 s (FEV1) percent predicted and 3.5% (95% CI 2.74 to 4.18) decrease in forced vital capacity (FVC) percent predicted, respectively. Trends towards decreased pulmonary function measures were seen for longer duration and greater amount of household fuel use at home, in the highest compared with lowest tertile (p values for trend <0.001). We observed decrease in FEV1 and FVC percent predicted across increase in tertile of body mass index in association with in-home solid fuel exposure.
   Conclusions This study suggests that in-home solid fuel exposure is associated with reduced lung function in an urban population.
C1 [Lee, Mi-Sun; Su, Li; Zhao, Yang; Christiani, David C.] Harvard Univ, Sch Publ Hlth, Environm & Occupat Med & Epidemiol Program, Dept Environm Hlth, Boston, MA 02115 USA.
   [Hang, Jing-qing; Zhang, Feng-ying; Zheng, Bu-yong; Dai, He-lian; Zhang, Hong-xi] Shanghai Putuo Dist Peoples Hosp, Shanghai, Peoples R China.
   [Christiani, David C.] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Boston, MA 02115 USA.
C3 Harvard University; Harvard T.H. Chan School of Public Health; Harvard
   University; Harvard Medical School; Harvard University Medical
   Affiliates; Massachusetts General Hospital
RP Christiani, DC (corresponding author), Harvard Univ, Sch Publ Hlth, Environm & Occupat Med & Epidemiol Program, Dept Environm Hlth, 665 Huntington Ave,Bldg 1,Room 1401, Boston, MA 02115 USA.
EM dchris@hsph.harvard.edu
RI 丽, 苏/JVO-8581-2024; zhao, yang/GXF-4424-2022
FU National Institute of Environmental Health Science [ES000002]; National
   Institute for Occupational Safety and Health [R010421]; Shanghai Putuo
   District People's Hospital
FX This study was supported by grants from the National Institute of
   Environmental Health Science (Grant ES000002); and the National
   Institute for Occupational Safety and Health (Grant R010421); and
   Shanghai Putuo District People's Hospital.
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NR 29
TC 8
Z9 11
U1 0
U2 14
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 1351-0711
EI 1470-7926
J9 OCCUP ENVIRON MED
JI Occup. Environ. Med.
PD FEB
PY 2013
VL 70
IS 2
BP 120
EP 125
DI 10.1136/oemed-2011-100569
PG 6
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA 074FC
UT WOS:000313797300008
PM 23155189
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Arcidiacono, B
   Iiritano, S
   Nocera, A
   Possidente, K
   Nevolo, MT
   Ventura, V
   Foti, D
   Chiefari, E
   Brunetti, A
AF Arcidiacono, Biagio
   Iiritano, Stefania
   Nocera, Aurora
   Possidente, Katiuscia
   Nevolo, Maria T.
   Ventura, Valeria
   Foti, Daniela
   Chiefari, Eusebio
   Brunetti, Antonio
TI Insulin Resistance and Cancer Risk: An Overview of the Pathogenetic
   Mechanisms
SO EXPERIMENTAL DIABETES RESEARCH
LA English
DT Review
ID HUMAN BREAST-CANCER; ACTIVATED RECEPTOR-GAMMA; GROWTH-FACTOR-I;
   DIABETES-MELLITUS; ADIPOSE-TISSUE; NUTRITIONAL REGULATION; METABOLIC
   SYNDROME; PANCREATIC-CANCER; OXIDATIVE STRESS; GENE-EXPRESSION
AB Insulin resistance is common in individuals with obesity or type 2 diabetes (T2D), in which circulating insulin levels are frequently increased. Recent epidemiological and clinical evidence points to a link between insulin resistance and cancer. The mechanisms for this association are unknown, but hyperinsulinaemia (a hallmark of insulin resistance) and the increase in bioavailable insulin-like growth factor I (IGF-I) appear to have a role in tumor initiation and progression in insulin-resistant patients. Insulin and IGF-I inhibit the hepatic synthesis of sex-hormone binding globulin (SHBG), whereas both hormones stimulate the ovarian synthesis of sex steroids, whose effects, in breast epithelium and endometrium, can promote cellular proliferation and inhibit apoptosis. Furthermore, an increased risk of cancer among insulin-resistant patients can be due to overproduction of reactive oxygen species (ROS) that can damage DNA contributing to mutagenesis and carcinogenesis. On the other hand, it is possible that the abundance of inflammatory cells in adipose tissue of obese and diabetic patients may promote systemic inflammation which can result in a protumorigenic environment. Here, we summarize recent progress on insulin resistance and cancer, focusing on various implicated mechanisms that have been described recently, and discuss how these mechanisms may contribute to cancer initiation and progression.
C1 [Arcidiacono, Biagio; Iiritano, Stefania; Nocera, Aurora; Possidente, Katiuscia; Nevolo, Maria T.; Ventura, Valeria; Foti, Daniela; Chiefari, Eusebio; Brunetti, Antonio] Magna Graecia Univ Catanzaro, Dept Hlth Sci, I-88100 Catanzaro, Italy.
C3 Magna Graecia University of Catanzaro
RP Brunetti, A (corresponding author), Magna Graecia Univ Catanzaro, Dept Hlth Sci, Viale Europa Localita Germaneto, I-88100 Catanzaro, Italy.
EM brunetti@unicz.it
RI Brunetti, Antonio/K-7756-2016; Arcidiacono, Biagio/I-6040-2019; Foti,
   Daniela/K-8038-2016; Chiefari, Eusebio/Y-2558-2019
OI Brunetti, Antonio/0000-0003-1533-8779; Chiefari,
   Eusebio/0000-0001-5329-3124; Foti, Daniela/0000-0002-9536-5736; VENTURA,
   Valeria/0000-0001-6378-9916
FU MIUR (Italy) [2004062059-002]; Associazione "E Solidarieta" (Crotone,
   Italy); Cotronei, Italy
FX Research support has been received from MIUR (Protocol 2004062059-002
   Italy) to A. Brunetti The authors acknowledge financial support from Dr.
   Belcastro, Mrs Baffa, and Mrs Tiano (Cotronei, Italy) and from
   Associazione "E Solidarieta" (Crotone, Italy).
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NR 126
TC 422
Z9 465
U1 0
U2 49
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1687-5214
EI 1687-5303
J9 EXP DIABETES RES
JI Exp. Diabetes Res.
PY 2012
AR 789174
DI 10.1155/2012/789174
PG 12
WC Endocrinology & Metabolism; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Research & Experimental Medicine
GA 963MG
UT WOS:000305624200001
PM 22701472
OA Green Submitted, Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Thounaojam, MC
   Jadeja, RN
   Devkar, RV
   Ramachandran, AV
AF Thounaojam, Menaka Chanu
   Jadeja, Ravirajsinh Navalsinh
   Devkar, Ranjisinh Vijaysinh
   Ramachandran, Ayalur Vadathala
TI Non-alcoholic steatohepatitis: an overview including treatments with
   herbals as alternative therapeutics
SO JOURNAL OF APPLIED BIOMEDICINE
LA English
DT Review
DE non-alcoholic steatohepatitis; herbal medicine; phytocompounds;
   polyherbal formulation
ID FATTY LIVER-DISEASE; HEN-SHI-KO; PLACEBO-CONTROLLED TRIAL; HEPATIC
   STEATOSIS; INSULIN-RESISTANCE; OXIDATIVE STRESS; VITAMIN-E; METABOLIC
   SYNDROME; TEUCRIUM-POLIUM; OB/OB MICE
AB Non-alcoholic steatohepatitis (NASH), an under-recognized hepatic ailment with increasing prevalence, is fast emerging as the dark horse of hepatic related morbidity and mortality. Though introduced as a hepatic condition as early as 1980, detailed exploration of its causes, underlying mechanisms and therapeutics has largely remained an ignored or neglected field. Only recently, the focus of attention has gravitated towards an understanding of NASH as a pathological manifestation of significance and a search for possible therapeutic interventions. Treatment schedules as of now involve life style management and usage of anti-diabetic or anti-obesity drugs and antioxidants. In the present review, we have focused on the available treatment schedules including herbal agents, plant extracts, polyherbal formulations and isolated phytocompounds. We present here a review of the available literature on pre-clinical and clinical evaluations of herbals including our recent findings on two plant extracts which can be used in mitigating NASH. This review attempts to provide a comprehensive account of NASH and the future of therapeutics and remediation by herbal principles, an aspect of the urgent need to target this important medical condition that contributes to many cases of silent morbidity and mortality.
C1 [Thounaojam, Menaka Chanu; Jadeja, Ravirajsinh Navalsinh; Devkar, Ranjisinh Vijaysinh; Ramachandran, Ayalur Vadathala] Maharaja Sayajirao Univ Baroda, Fac Sci, Div Phytotherapeut & Metab Endocrinol, Dept Zool, Vadodara 390002, Gujarat, India.
C3 Maharaja Sayajirao University Baroda
RP Devkar, RV (corresponding author), Maharaja Sayajirao Univ Baroda, Fac Sci, Div Phytotherapeut & Metab Endocrinol, Dept Zool, Vadodara 390002, Gujarat, India.
EM phyto_met@yahoo.com
RI Thounaojam, Menaka/AAO-5842-2020; Jadeja, Ravirajsinh/G-3116-2011
OI Thounaojam, menaka/0000-0002-3422-2053; Jadeja,
   Ravirajsinh/0000-0002-1712-454X; A. V., Ramachandran/0000-0002-2326-0994
FU University Grants Commission; Council of scientific and Industrial
   Research, New Delhi India
FX Authors Menaka Chanu Thounaojam and Ravirajsinh Navalsinh Jadeja are
   thankful to the University Grants Commission and Council of scientific
   and Industrial Research, New Delhi India for providing financial
   assistance in the form of RFSMS and CSIR-SRF fellowships respectively.
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NR 151
TC 9
Z9 9
U1 0
U2 10
PU UNIV SOUTH BOHEMIA
PI CESKA BUDEJOVICE
PA FAC HEALTH & SOCIAL STUD, JIROVCOVA, CESKA BUDEJOVICE, 370 04, CZECH
   REPUBLIC
SN 1214-021X
EI 1214-0287
J9 J APPL BIOMED
JI J. Appl. Biomed.
PY 2012
VL 10
IS 3
BP 119
EP 136
DI 10.2478/v10136-012-0008-9
PG 18
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA 944GX
UT WOS:000304188400001
OA Bronze
DA 2025-06-11
ER

PT J
AU Pu, SH
   Li, Q
   Tao, ZJ
   Wang, SB
   Meng, XY
   Wang, SQ
   Wang, ZJ
AF Pu, Shihang
   Li, Qi
   Tao, Zhijun
   Wang, Songbo
   Meng, Xiangyu
   Wang, Shangqian
   Wang, Zengjun
TI Associations between Urinary Concentrations of Polycyclic Aromatic
   Hydrocarbons and Overactive Bladder in US Adults: Data from the National
   Health and Nutrition Examination Survey 2005-2016
SO UROLOGIA INTERNATIONALIS
LA English
DT Article
DE Polycyclic aromatic hydrocarbons; Overactive bladder; NHANES;
   Reproduction toxicity
ID CHEMISTRY; SYMPTOMS
AB Introduction: Polycyclic aromatic hydrocarbons (PAHs) are a group of chemicals that can induce oxidative stress and related cytotoxicity. Whether urinary concentrations of PAHs have effects on overactive bladder (OAB) in the general population is still unclear. This study investigated the associations between urinary PAHs and OAB. Methods: 7,146 adults aged over 20 who participated in the US National Health and Nutrition Examination Survey 2005-2016 were studied. The impact of the six PAHs on OAB was evaluated by multivariate logistic regression, and percent changes related to different quartiles of those six PAH levels were calculated. Confounders including age, logarithmic urinary creatinine, gender, race, body mass index, educational level, marriage, poverty income ratio, diabetes, hypertension, and metabolic syndrome were controlled. Results: There is a significant positive correlation between urinary concentrations of the six PAHs we include in the study and the occurrence of OAB. Furthermore, individuals with higher PAH levels also reported a more severe OAB symptom score (OABSS). Conclusions: Our findings revealed that adult men in the USA with higher urinary PAHs had a higher risk of OAB incidence. These findings suggest the importance of strong environmental regulation of PAHs to protect population health. However, the underlying mechanisms still need further exploration.
C1 [Pu, Shihang; Li, Qi; Tao, Zhijun; Wang, Songbo; Meng, Xiangyu; Wang, Shangqian; Wang, Zengjun] Nanjing Med Univ, Affiliated Hosp 1, Dept Urol, Nanjing, Peoples R China.
C3 Nanjing Medical University
RP Wang, SQ; Wang, ZJ (corresponding author), Nanjing Med Univ, Affiliated Hosp 1, Dept Urol, Nanjing, Peoples R China.
EM wsq5501@126.com; zengjunwang@njmu.edu.cn
RI wang, songbo/AAY-4409-2020; wang, yuyan/HNC-3272-2023; Meng,
   Xiangyu/AHE-4230-2022
FU Jiangsu Province Capability Improvement Project through Science,
   Technology and Education [ZDXK202219]; Postgraduate Research & Practice
   Innovation Program of Jiangsu Province [SJCX22_0680]
FX Jiangsu Province Capability Improvement Project through Science,
   Technology and Education [Grant No. ZDXK202219] Postgraduate Research &
   Practice Innovation Program of Jiangsu Province [Grant No. SJCX22_0680].
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NR 28
TC 2
Z9 2
U1 1
U2 7
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0042-1138
EI 1423-0399
J9 UROL INT
JI Urol.Int.
PD APR
PY 2024
VL 108
IS 2
BP 137
EP 145
DI 10.1159/000536253
PG 9
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA NB1L4
UT WOS:001197888200003
PM 38219726
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Badawy, S
   Liu, YA
   Guo, MY
   Liu, ZL
   Xie, CQ
   Marawan, MA
   Ares, I
   Lopez-Torres, B
   Martinez, M
   Maximiliano, JE
   Martínez-Larrañaga, MR
   Wang, X
   Anadón, A
   Martínez, MA
AF Badawy, Sara
   Liu, Yanan
   Guo, Mingyue
   Liu, Zhenli
   Xie, Changqing
   Marawan, Marawan A.
   Ares, Irma
   Lopez-Torres, Bernardo
   Martinez, Marta
   Maximiliano, Jorge-Enrique
   Martinez-Larranaga, Maria-Rosa
   Wang, Xu
   Anadon, Arturo
   Martinez, Maria-Aranzazu
TI Conjugated linoleic acid (CLA) as a functional food: Is it beneficial or
   not?
SO FOOD RESEARCH INTERNATIONAL
LA English
DT Review
DE Conjugated linoleic acid; Functional food; Health benefits; CLA adverse
   effects; Toxicity
ID POLYUNSATURATED FATTY-ACIDS; BONE-MINERAL DENSITY; IN-VITRO MATURATION;
   GAMMA PPAR-GAMMA; INSULIN-RESISTANCE; BODY-COMPOSITION; OXIDATIVE
   STRESS; LIPID PROFILE; ENDURANCE CAPACITY; VITAMIN-A
AB Conjugated linoleic acid (CLA) has attracted great attention in recent years as a popular class of functional food that is broadly used. It refers to a group of geometric and positional isomers of linoleic acid (LA) with a conjugated double bond. The main natural sources of CLA are dairy products, beef and lamb, whereas only trace amounts occur naturally in plant lipids. CLA has been shown to improve various health issues, having effects on obesity, inflammatory, anti-carcinogenicity, atherogenicity, immunomodulation, and osteosynthesis. Also, compared to studies on humans, many animal researches reveal more positive benefits on health. CLA represents a nutritional avenue to improve lifestyle diseases and metabolic syndrome. Most of these effects are attributed to the two major CLA isomers [conjugated linoleic acid cis-9,trans-11 isomer (c9,t11), and conjugated linoleic acid trans-10,cis-12 isomer (t10,c12)], and their mixture (CLA mix). In contrast, adverse effects of CLA have been also reported, such as glucose homeostasis, insulin resistance, hepatic steatosis and induction of colon carcinogenesis in humans, as well as milk fat inhibition in ruminants, lowering chicken productivity, influencing egg quality and
C1 [Badawy, Sara; Wang, Xu] Huazhong Agr Univ, Natl Reference Lab Vet Drug Residues HZAU, MAO Key Lab Detect Vet Drug Residues, Wuhan 430070, Hubei, Peoples R China.
   [Badawy, Sara] Benha Univ, Fac Vet Med, Pathol Dept Anim Med, Banha, Egypt.
   [Liu, Yanan; Guo, Mingyue; Liu, Zhenli; Xie, Changqing; Wang, Xu] Huazhong Agr Univ, MAO Lab Risk Assessment Qual & Safety Livestock &, Wuhan 430070, Hubei, Peoples R China.
   [Marawan, Marawan A.] Huazhong Agr Univ, State Key Lab Agr Microbiol, Wuhan 430070, Hubei, Peoples R China.
   [Marawan, Marawan A.] Benha Univ, Fac Vet Med, Anim Med Dept, Infect Dis, Banha, Egypt.
   [Ares, Irma; Lopez-Torres, Bernardo; Martinez, Marta; Maximiliano, Jorge-Enrique; Martinez-Larranaga, Maria-Rosa; Anadon, Arturo; Martinez, Maria-Aranzazu] Univ Complutense Madrid UCM, Fac Vet Med, Dept Pharmacol & Toxicol, Madrid 28040, Spain.
   [Ares, Irma; Lopez-Torres, Bernardo; Martinez, Marta; Maximiliano, Jorge-Enrique; Martinez-Larranaga, Maria-Rosa; Anadon, Arturo; Martinez, Maria-Aranzazu] Res Inst Hosp 12 Octubre i 12, Madrid 28040, Spain.
   [Wang, Xu; Anadon, Arturo] Univ Complutense Madrid, Fac Vet Med, Dept Pharmacol & Toxicol, Madrid 28040, Spain.
C3 Huazhong Agricultural University; Egyptian Knowledge Bank (EKB); Benha
   University; Huazhong Agricultural University; Huazhong Agricultural
   University; Egyptian Knowledge Bank (EKB); Benha University; Complutense
   University of Madrid; Complutense University of Madrid
RP Wang, X; Anadón, A (corresponding author), Univ Complutense Madrid, Fac Vet Med, Dept Pharmacol & Toxicol, Madrid 28040, Spain.
EM wangxu@mail.hzau.edu.cn; aanadon@ucm.es
RI MARTINEZ, MARTA/D-2146-2015; Guo, Mingyue/MSV-4606-2025; Maximiliano,
   Jorge-Enrique/AAY-3731-2021; Torres, Bernardo/AAM-7619-2020; Martínez
   Calle, Marta/H-1451-2015; xie, chang/GYJ-2493-2022
OI Ares, Irma/0000-0002-8762-1488; Maximiliano, Jorge/0000-0001-9678-2200;
   Lopez Torres, Bernardo/0000-0002-1393-5919
FU National Natural Science Foundation of China (NSFC) [32072925];
   Fundamental Research Funds for the Central Universities of China
   [2662020DKPY020, PID2020-115979RR-C33]; Ministerio de Ciencia e
   Innovacio ' n, Spain
FX This work was supported by National Natural Science Foundation of China
   (NSFC) (32072925) , the Fundamental Research Funds for the Central
   Universities of China (2662020DKPY020) , and Project Ref.
   PID2020-115979RR-C33 from Ministerio de Ciencia e Innovacio ' n, Spain
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NR 314
TC 58
Z9 58
U1 35
U2 113
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0963-9969
EI 1873-7145
J9 FOOD RES INT
JI Food Res. Int.
PD OCT
PY 2023
VL 172
AR 113158
DI 10.1016/j.foodres.2023.113158
EA JUL 2023
PG 26
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA M4BZ3
UT WOS:001029677200001
PM 37689911
OA hybrid
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Nishi, K
   Ito, T
   Kadota, A
   Ishida, M
   Nishiwaki, H
   Fukuda, N
   Kanamoto, N
   Nagata, Y
   Sugahara, T
AF Nishi, Kosuke
   Ito, Takako
   Kadota, Ayumu
   Ishida, Momoko
   Nishiwaki, Hisashi
   Fukuda, Naohiro
   Kanamoto, Naoaki
   Nagata, Yoko
   Sugahara, Takuya
TI Aqueous Extract from Leaves of Citrus unshiu Attenuates
   Lipopolysaccharide-Induced Inflammatory Responses in a Mouse Model of
   Systemic Inflammation
SO PLANTS-BASEL
LA English
DT Article
DE inflammation; Citrus unshiu; lipopolysaccharide; RAW 264.7 cell;
   systemic inflammation model
ID ACUTE LUNG INJURY; NF-KAPPA-B; NITRIC-OXIDE; IL-6 PRODUCTION;
   HESPERIDIN; ACTIVATION; STRESS; CELLS; SHOCK
AB Inflammation is related to various life-threatening diseases including cancer, neurodegenerative diseases, and metabolic syndrome. Because macrophages are prominent inflammatory cells, regulation of macrophage activation is a key issue to control the onset of inflammation-associated diseases. In this study, we aimed to evaluate the potential anti-inflammatory activity of Citrus unshiu leaf extract (CLE) and to elucidate the mechanism underlying its anti-inflammatory effect. We found the inhibitory activity of CLE on the secretion of proinflammatory cytokines and a chemokine from mouse macrophage-like RAW 264.7 cells and mouse peritoneal macrophages. The inhibitory activity of CLE was attributed to downregulated JNK, p38 MAPK, and NF-kappa B signaling pathways, leading to suppressed gene expression of inflammation-associated proteins. Oral administration of CLE significantly decreased the serum level of proinflammatory cytokines IL-6 and TNF alpha and increased that of anti-inflammatory cytokine IL-10 in lipopolysaccharide-induced systemic inflammation mice. In addition, oral administration of CLE decreased secretion and gene expression of several proinflammatory proteins in the liver and spleen of the model mice. Overall results revealed that C. unshiu leaf is effective to attenuate inflammatory responses in vitro and in vivo.
C1 [Nishi, Kosuke; Ito, Takako; Ishida, Momoko; Nishiwaki, Hisashi; Sugahara, Takuya] Ehime Univ, Grad Sch Agr, Dept Biosci, Matsuyama, Ehime 7908566, Japan.
   [Nishi, Kosuke; Sugahara, Takuya] Ehime Univ, Food & Hlth Sci Res Ctr, Matsuyama, Ehime 7908566, Japan.
   [Kadota, Ayumu] Ikata Serv Inc, Matsuyama, Ehime 7960421, Japan.
   [Fukuda, Naohiro; Kanamoto, Naoaki; Nagata, Yoko] Ehime Inst Ind Technol, Matsuyama, Ehime 7901101, Japan.
C3 Ehime University; Ehime University
RP Sugahara, T (corresponding author), Ehime Univ, Grad Sch Agr, Dept Biosci, Matsuyama, Ehime 7908566, Japan.; Sugahara, T (corresponding author), Ehime Univ, Food & Hlth Sci Res Ctr, Matsuyama, Ehime 7908566, Japan.
EM nishi.kosuke.mx@ehime-u.ac.jp; ito_takako@miuraz.co.jp;
   a_noi@ikata-s.co.jp; ishida.momoko.vb@ehime-u.ac.jp;
   nishiwaki.hisashi.mg@ehime-u.ac.jp; fukuda-naohiro@pref.ehime.lg.jp;
   kanamoto-naoaki@pref.ehime.lg.jp; nagata-youko@pref.ehime.lg.jp;
   mars95@agr.ehime-u.ac.jp
RI Nishi, Kosuke/M-8759-2018
OI Nishi, Kosuke/0000-0003-4205-8465; Sugahara, Takuya/0000-0002-0335-8273
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NR 42
TC 4
Z9 4
U1 0
U2 9
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 2223-7747
J9 PLANTS-BASEL
JI Plants-Basel
PD AUG
PY 2021
VL 10
IS 8
AR 1708
DI 10.3390/plants10081708
PG 16
WC Plant Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences
GA UH4EK
UT WOS:000689886200001
PM 34451753
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Chen, PJ
   Lu, YC
   Wang, PM
   Huang, CF
   Loke, SS
AF Chen, Po-Ju
   Lu, Yueh-Chien
   Wang, Pei-Ming
   Huang, Chih-Fang
   Loke, Song-Seng
TI Factors associated with hyperhomocysteinemia in relatively healthy
   Taiwanese adults A retrospective medical record study
SO MEDICINE
LA English
DT Article
DE homocysteine; metabolic factors; uric acid; metabolic syndrome
ID HOMOCYSTEINE LEVELS; DETERMINANTS; RISK; POPULATION; DISEASE; STRESS;
   STROKE
AB Elevated homocysteine levels have been proposed as a risk factor for cardiovascular disease. The aim of this study was to evaluate factors associated with hyperhomocysteinemia in relatively healthy Taiwanese adults. A retrospective cross-sectional study was conducted using data from the health examination database in a medical center located in southern Taiwan. Hyperhomocysteinemia was defined as a plasma homocysteinemia level >15 mu mol/L. Factors associated with hyperhomocysteinemia were evaluated using univariate and multiple stepwise logistic regression analyses. A total of 817 adults with a mean age of 55.5 years were included in the present study, and of them, 67 (8.2%) had hyperhomocysteinemia. Results from multiple logistic regression analysis showed that male sex (Odd ratio [OR] = 12.28, 95% CI = 2.94-51.27, P = .001), advanced age (OR = 1.37 per 10 years, 95% CI = 1.06-1.77, P = .017), triglycerides (OR = 1.02 per 10 mg/dL, 95% CI = 1.01-1.04, P = .010), and uric acid (OR = 1.27, 95% CI = 1.09-1.49, P = .004) were significantly and independently associated with hyperhomocysteinemia. In this retrospective medical record study, male sex, advanced age, higher plasma level of triglyceride, and uric acid were significantly associated with hyperhomocysteinemia in relatively healthy Taiwanese adults.
C1 [Chen, Po-Ju; Lu, Yueh-Chien; Wang, Pei-Ming; Huang, Chih-Fang; Loke, Song-Seng] Kaohsiung Chang Gung Mem Hosp, Dept Family Med, Kaohsiung 833, Taiwan.
   [Chen, Po-Ju; Lu, Yueh-Chien; Wang, Pei-Ming; Huang, Chih-Fang; Loke, Song-Seng] Chang Gung Univ, Coll Med, Kaohsiung 833, Taiwan.
   [Huang, Chih-Fang] Chung Hwa Univ Med Technol, Dept Long Term Care & Management, Tainan, Taiwan.
C3 Chang Gung Memorial Hospital; Chang Gung University; Chung Hua
   University
RP Loke, SS (corresponding author), Kaohsiung Chang Gung Mem Hosp, Dept Family Med, Kaohsiung 833, Taiwan.; Loke, SS (corresponding author), Chang Gung Univ, Coll Med, Kaohsiung 833, Taiwan.
EM loke@adm.cgmh.org.tw
OI Chen, Po-Ju/0000-0003-1204-3027; Lu, Yueh-Chien/0000-0001-7582-1573
CR Ai YB, 2017, NUTRIENTS, V9, DOI 10.3390/nu9040346
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NR 28
TC 8
Z9 9
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD JAN 22
PY 2021
VL 100
IS 3
AR e23829
DI 10.1097/MD.0000000000023829
PG 4
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA PZ6FV
UT WOS:000612835100028
PM 33545948
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Garbarino, S
   Tripepi, G
   Magnavita, N
AF Garbarino, Sergio
   Tripepi, Giovanni
   Magnavita, Nicola
TI Sleep Health Promotion in the Workplace
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Article
DE workplace health promotion; sleep quality; sleep hygiene; sleepiness;
   safety; insomnia; sleep deprivation; injury; near-miss; police
ID POLICE OFFICERS; METABOLIC SYNDROME; RISK; DURATION; FATIGUE; STRESS;
   ASSOCIATION; MANAGEMENT; DISORDERS; ACCIDENTS
AB Poor sleep and sleepiness in the workplace are associated with accidents. A workplace sleep health promotion program was implemented in an Italian police unit. Of the 242 police officers in the unit, 218 (90%) agreed to take part in the program. A crossover trial was made in which the police officers were divided into two groups that performed sleep health promotion activities in the first and second year, respectively. The first group of officers showed significant sleep improvements at the end of the first year, while the second group had similar or worse parameters than at baseline. At follow-up, a significant improvement in the quantity and quality of sleep was reported in both groups. Sleep improvements at follow-up were associated with a marked reduction in the frequency of accidents at work and near-misses. Before the intervention, sleepiness was the best predictor of injuries (aOR 1.220; CI95% 1.044-1.426) and near-misses (aOR 1.382; CI95% 1.182-1.615). At follow-up, when sleep conditions had improved, insomnia symptoms were the most significant predictors of work accidents (aOR 13.358; CI95% 2.353-75.818). Sleep health promotion can be useful in police officers.
C1 [Garbarino, Sergio; Magnavita, Nicola] Univ Cattolica Sacro Cuore, Postgrad Sch Occupat Med, I-00168 Rome, Italy.
   [Garbarino, Sergio] Minist Interior, State Police Hlth Serv Dept, I-00198 Rome, Italy.
   [Garbarino, Sergio] Univ Genoa, Dept Neurosci Rehabil Ophthalmol Genet & Maternal, I-16126 Genoa, Italy.
   [Tripepi, Giovanni] Italian Natl Res Council, Inst Clin Physiol, Res Unit Reggio Calabria, I-89124 Calabria, Italy.
   [Magnavita, Nicola] Fdn Policlin Agostino Gemelli IRCCS, Dept Woman Child & Publ Hlth, I-00168 Rome, Italy.
C3 Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli;
   University of Genoa; Consiglio Nazionale delle Ricerche (CNR)
RP Garbarino, S (corresponding author), Univ Cattolica Sacro Cuore, Postgrad Sch Occupat Med, I-00168 Rome, Italy.; Garbarino, S (corresponding author), Minist Interior, State Police Hlth Serv Dept, I-00198 Rome, Italy.; Garbarino, S (corresponding author), Univ Genoa, Dept Neurosci Rehabil Ophthalmol Genet & Maternal, I-16126 Genoa, Italy.
EM sgarbarino.neuro@gmail.com; gtripepi@ifc.cnr.it;
   nicola.magnavita@unicatt.it
RI Magnavita, Nicola/J-6074-2014; Garbarino, Sergio/X-5368-2018
OI Garbarino, Sergio/0000-0002-8508-552X
CR Åkerstedt T, 2011, PROG BRAIN RES, V190, P169, DOI 10.1016/B978-0-444-53817-8.00011-6
   [Anonymous], **NON-TRADITIONAL**
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NR 54
TC 17
Z9 17
U1 0
U2 14
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD NOV
PY 2020
VL 17
IS 21
AR 7952
DI 10.3390/ijerph17217952
PG 14
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA OQ7VB
UT WOS:000588984900001
PM 33138203
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Lee, DH
   Park, SH
   Huh, YH
   Kim, MJ
   Seo, HD
   Ha, TY
   Ahn, J
   Jang, YJ
   Jung, CH
AF Lee, Da-Hye
   Park, So-Hyun
   Huh, Yang Hoon
   Kim, Min Jung
   Seo, Hyo-Deok
   Ha, Tae-Youl
   Ahn, Jiyun
   Jang, Young-Jin
   Jung, Chang Hwa
TI Iridoids of Valeriana fauriei contribute to alleviating hepatic
   steatosis in obese mice by lipophagy
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Article
DE Nonalcoholic fatty liver disease; Valerianafauriei; Autophagy; Iridoids;
   mTORC1
ID FATTY LIVER-DISEASE; AUTOPHAGIC FLUX; MTOR; ACID; PHOSPHORYLATION;
   ACCUMULATION; METABOLISM; INHIBITOR; STRESS; CELLS
AB Nonalcoholic fatty liver disease (NAFLD) is a common risk factor for metabolic syndrome that increases the risk of future cardiovascular disease, stroke, and diabetes. Recently, autophagy has been proposed as a means to prevent NAFLD. We investigated whether substances with autophagy-inducing activity alleviate NAFLD. The Valeriana fauriei (V. fauriei) was selected as a potential autophagy inducer among various natural materials using a Cyto-ID autophagy detection kit. V. fauriei 70 % ethanol extract (VFE) increased LC3II levels in the presence of the lysosomal inhibitor and reduced the GFP/mCherry puncta ratio, suggesting that VFE enhanced autophagy. VFE reduced oleic acid (OA)-induced lipid accumulation and increased the number of autophagosome in hepatocytes. Autophagy induction by VFE is due to inhibition of mTORC1 activity. VFE supplementation reduced fatty liver by downregulating lipogenesis-related genes and increased the autophagy, as revealed by TEM and IHC analysis in the fatty liver. We identified iridoids as main compounds of VFE; didrovaltrate (DI), valeriotriate B (VAL B), valeriotetrate C (VAL C), valtrate (VAL), and valechlorine (VC) were shown to enhance autophagy. These compounds also reduced OA-induced lipid accumulation in an Atg5-dependent manner. Taken together, VFE and its iridoids might be effective in alleviating fatty liver by acting as autophagy enhancers to break down LDs.
C1 [Lee, Da-Hye; Park, So-Hyun; Kim, Min Jung; Seo, Hyo-Deok; Ha, Tae-Youl; Ahn, Jiyun; Jang, Young-Jin; Jung, Chang Hwa] Korea Food Res Inst, Res Div Food Funct, Wanju Gun 55365, Jeollabuk Do, South Korea.
   [Lee, Da-Hye; Park, So-Hyun; Ha, Tae-Youl; Ahn, Jiyun; Jung, Chang Hwa] Univ Sci & Technol, Dept Food Biotechnol, Daejoen 34113, South Korea.
   [Huh, Yang Hoon] Korea Basic Sci Inst, Ctr Electron Microscopy Res, Cheongju 28119, South Korea.
C3 Korea Food Research Institute (KFRI); Korea Basic Science Institute
   (KBSI)
RP Jung, CH (corresponding author), Korea Food Res Inst, Wanju Gun 55365, Jeollabuk Do, South Korea.
EM chjung@kfri.re.kr
RI Jang, Young/AAT-1192-2020
OI Jang, Young Jin/0000-0003-0553-2498
FU Main Research Program of the Korea Food Research Institute - Ministry of
   Science, and ICT [E0187400]; Korea Basic Science Institute [T37416]
FX This study was supported by the Main Research Program (E0187400) of the
   Korea Food Research Institute funded by the Ministry of Science, and
   ICT. TEM image analysis was supported by the Korea Basic Science
   Institute (T37416 to Y.H.H).
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NR 49
TC 18
Z9 18
U1 3
U2 23
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD MAY
PY 2020
VL 125
AR 109950
DI 10.1016/j.biopha.2020.109950
PG 12
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA KU2DX
UT WOS:000519520000068
PM 32058217
OA gold
DA 2025-06-11
ER

PT J
AU Irondi, EA
AF Irondi, Emmanuel Anyachukwu
TI Phenolics-rich extract of guava stem bark inhibits enzymes associated
   with nephrolithiasis and obesity in vitro
SO JOURNAL OF COMPLEMENTARY MEDICINE RESEARCH
LA English
DT Article
DE Anti-radical; Enzymes inhibition; Guava stem bark; Nephrolithiasis;
   Obesity; Phenolics
ID URIC-ACID LEVELS; ANTIOXIDANT ACTIVITY; METABOLIC SYNDROME; L.; UREASE;
   GLUCOSIDASE; MECHANISMS; RESISTANCE; OVERWEIGHT; QUERCETIN
AB Aim: Inhibition of enzymes catalyzing the production of metabolites that predispose to metabolic diseases is an important index of the potential health benefits of natural products. In this study, the ability of guava (Psidium guajava Linn.) stem bark phenolics-rich extract to inhibit enzymes associated with nephrolithiasis (xanthine oxidase and urease) and obesity [pancreatic lipase and 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase] was evaluated in vitro.
   Methods: The phenolics profile of the extract was determined using HPLC-DAD; while the enzymes inhibitory and anti-radical properties of the extract were tested using spectrophotometric methods.
   Results: HPLC-DAD fingerprinting revealed that ellagic acid and quercetin were the most abundant phenolic acid and flavonoids, respectively, in the extract. The extract inhibited xanthine oxidase, urease, pancreatic lipase and HMG-CoA reductase, with IC50 values below 40 mu g/ml. The extract also exhibited potent anti-radical activity by scavenging ABTS*(+), DPPH* and chelating F2+.
   Conclusions: Hence, guava stem bark may be a source of nutraceuticals for suppressing the production of uric acid, ammonium hydroxide, fatty acids and cholesterol, and mitigating oxidative stress. These bioactivities, which can be attributed to the phenolic compounds, suggest anti-nephrolithiatic and anti-obesity potentials of guava stem bark phenolics-rich extract.
C1 [Irondi, Emmanuel Anyachukwu] Kwara State Univ, Dept Med Biochem & Pharmacol, PMB 1530, Ilorin, Nigeria.
RP Irondi, EA (corresponding author), Kwara State Univ, Dept Med Biochem & Pharmacol, PMB 1530, Ilorin, Nigeria.
EM emmanuel.irondi@kwasu.edu.ng
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NR 51
TC 1
Z9 1
U1 0
U2 9
PU EJMANAGER LLC
PI WILMINGTON
PA 913 N MARKET ST, STE 200, WILMINGTON, DE 19801 USA
SN 2146-8397
EI 2577-5669
J9 J COMPL MED RES
JI J. Compl. Med. Res.
PY 2020
VL 11
IS 1
BP 34
EP 42
DI 10.5455/jcmr.2020.11.01.05
PG 9
WC Pharmacology & Pharmacy
WE Emerging Sources Citation Index (ESCI)
SC Pharmacology & Pharmacy
GA MA1VH
UT WOS:000541705200005
DA 2025-06-11
ER

PT J
AU Chiang, BJ
   Kuo, HC
   Liao, CH
AF Chiang, Bing-Juin
   Kuo, Hann-Chorng
   Liao, Chun-Hou
TI Can Botulinum Toxin A Still Have a Role in Treatment of Lower Urinary
   Tract Symptoms/Benign Prostatic Hyperplasia Through Inhibition of
   Chronic Prostatic Inflammation?
SO TOXINS
LA English
DT Review
DE lower urinary tract symptoms; botulinum toxin; benign prostatic
   hyperplasia; prostatitis; inflammation
ID NERVE GROWTH-FACTOR; PELVIC PAIN SYNDROME; BLADDER OUTFLOW OBSTRUCTION;
   BLOOD-FLOW; METABOLIC SYNDROME; EXPRESSION; INJECTION; MEN;
   PATHOPHYSIOLOGY; INTERLEUKIN-8
AB Patients with benign prostatic hyperplasia (BPH) can exhibit various lower urinary tract symptoms (LUTS) owing to bladder outlet obstruction (BOO), prostatic inflammation, and bladder response to BOO. The pathogenesis of BPH involves an imbalance of internal hormones and chronic prostatic inflammation, possibly triggered by prostatic infection, autoimmune responses, neurogenic inflammation, oxidative stress, and autonomic dysfunction. Botulinum toxin A (BoNT-A) is well recognized for its ability to block acetylcholine release at the neuromuscular junction by cleaving synaptosomal-associated proteins. Although current large clinical trials have shown no clinical benefits of BoNT-A for the management of LUTS due to BPH, BoNT-A has demonstrated beneficial effects in certain subsets of BPH patients with LUTS, especially in males with concomitant chronic prostatitis/chronic pelvic pain syndrome and smaller prostate. We conducted a review of published literature in Pubmed, using Botulinum toxin, BPH, BOO, inflammation, LUTS, and prostatitis as the key words. This article reviewed the mechanisms of BPH pathogenesis and anti-inflammatory effects of BoNT-A. The results suggested that to achieve effectiveness, the treatment of BPH with BoNT-A should be tailored according to more detailed clinical information and reliable biomarkers.
C1 [Chiang, Bing-Juin; Liao, Chun-Hou] Fu Jen Catholic Univ, Coll Med, New Taipei 24205, Taiwan.
   [Chiang, Bing-Juin; Liao, Chun-Hou] Cardinal Tien Hosp, Dept Urol, New Taipei 23148, Taiwan.
   [Chiang, Bing-Juin] Natl Taiwan Normal Univ, Dept Life Sci, Coll Sci, Taipei 11677, Taiwan.
   [Kuo, Hann-Chorng] Buddhist Tzu Chi Gen Hosp, Dept Urol, Hualien 97002, Taiwan.
   [Kuo, Hann-Chorng] Tzu Chi Univ, Hualien 97002, Taiwan.
   [Kuo, Hann-Chorng] Tzu Chi Univ, Sch Med, Hualien 97004, Taiwan.
C3 Fu Jen Catholic University; National Taiwan Normal University; Buddhist
   Tzu Chi General Hospital; Hualien Tzu Chi Hospital; Tzu Chi University;
   Tzu Chi University
RP Liao, CH (corresponding author), Fu Jen Catholic Univ, Coll Med, New Taipei 24205, Taiwan.; Liao, CH (corresponding author), Cardinal Tien Hosp, Dept Urol, New Taipei 23148, Taiwan.
EM bingjuinchiang@gmail.com; hck@tzuchi.com.tw; liaoch22@gmail.com
RI Liao, ChunHou/B-8194-2012
OI Liao, Chun-Hou/0000-0002-7340-110X
FU Ministry of Science and Technology [106-2314-B-567-002-,
   107-2314-B-567-002-MY2-2]; Cardinal Tien Hospital [CTH106A-2A14,
   CTH107A-2A19]
FX This work was supported by the Ministry of Science and Technology
   (106-2314-B-567-002-, and 107-2314-B-567-002-MY2-2), and Cardinal Tien
   Hospital (CTH106A-2A14 and CTH107A-2A19).
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NR 98
TC 8
Z9 8
U1 2
U2 2
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6651
J9 TOXINS
JI Toxins
PD SEP
PY 2019
VL 11
IS 9
AR 547
DI 10.3390/toxins11090547
PG 11
WC Food Science & Technology; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Toxicology
GA JA6RA
UT WOS:000487968300065
PM 31546892
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Yeon, JY
   Bae, YJ
   Kim, EY
   Lee, EJ
AF Yeon, Jee-Young
   Bae, Yun Jung
   Kim, Eun-Young
   Lee, Eun-Ju
TI Association between flavonoid intake and diabetes risk among the Koreans
SO CLINICA CHIMICA ACTA
LA English
DT Article
DE Type 2 diabetes mellitus; Flavonoid; Impaired fasting glucose; Insulin;
   KNHANES
ID MAJOR FOOD SOURCES; INSULIN-RESISTANCE; DIETARY FLAVONOIDS; OXIDATIVE
   STRESS; CARDIOVASCULAR-DISEASE; WAIST CIRCUMFERENCE; METABOLIC SYNDROME;
   MALE SMOKERS; BETA-CELLS; GLUCOSE
AB Background: We investigated the association between flavonoid intake and type 2 diabetes mellitus (T2DM) risk factors including serum fasting glucose, insulin level, and insulin resistance.
   Methods: A total of 4186 participants who were involved in the 2007-2009 Korean National Health and Nutrition Examination Survey were examined. The participants were divided into 2 groups by fasting plasma glucose (FPG) as follows: normal fasting glucose (NFG; FPG <100 mg/dl) and impaired fasting glucose (IFG) groups (FPG >= 100 mg/dl).
   Results: In the IFG group, body weight, body mass index, and waist circumference were increased. Fasting insulin level and homeostasis model assessment estimate of insulin resistance as markers of insulin resistance were higher in the IFG group. Intakes of energy and nutrients, including protein, fat, carbohydrate, crude fiber, vitamin C, calcium, phosphorus, and iron, did not differ between the 2 groups. For the male subjects, the energy-adjusted flavanone intake was lower in the IFG group than in the NFG group. Insulin and insulin resistance were inversely correlated with intakes of flavones and flavonols among the male subjects.
   Conclusion: These findings can provide valuable information for further development of appropriate strategies for diabetes prevention in Korea. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Yeon, Jee-Young] Food Nutr & Dietary Safety Bur, Nutr Safety Policy Div, Minist Food & Drug Safety, Cheongju 361951, South Korea.
   [Bae, Yun Jung] Shinhan Univ, Div Food Sci & Culinary Arts, Dongducheon 480777, South Korea.
   [Kim, Eun-Young] Sookmyung Womens Univ, Dept Food & Nutr, Seoul, South Korea.
   [Lee, Eun-Ju] Asan Med Ctr, Asan Inst Life Sci, Seoul 138736, South Korea.
C3 Ministry of Food & Drug Safety (MFDS), Republic of Korea; Sookmyung
   Women's University; University of Ulsan; Asan Medical Center
RP Lee, EJ (corresponding author), Asan Inst Life Sci, 88 Olympicro 43 Gil, Seoul 138736, South Korea.
EM krys72@hanmail.net
RI Kim, YoungHwan/B-2395-2013; , 배윤정/J-8327-2019
OI BAE, YUN JUNG/0000-0003-1185-3095
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NR 44
TC 29
Z9 33
U1 0
U2 26
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0009-8981
EI 1873-3492
J9 CLIN CHIM ACTA
JI Clin. Chim. Acta
PD JAN 15
PY 2015
VL 439
BP 225
EP 230
DI 10.1016/j.cca.2014.10.042
PG 6
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA AY3RG
UT WOS:000347499700038
PM 25444741
DA 2025-06-11
ER

PT J
AU Gyllenhammer, LE
   Weigensberg, MJ
   Spruijt-Metz, D
   Allayee, H
   Goran, MI
   Davis, JN
AF Gyllenhammer, Lauren E.
   Weigensberg, Marc J.
   Spruijt-Metz, Donna
   Allayee, Hooman
   Goran, Michael I.
   Davis, Jaimie N.
TI Modifying Influence of Dietary Sugar in the Relationship Between
   Cortisol and Visceral Adipose Tissue in Minority Youth
SO OBESITY
LA English
DT Article
ID OVERWEIGHT LATINO YOUTH; METABOLIC SYNDROME; INSULIN SENSITIVITY;
   ENERGY-INTAKE; SERUM CORTISOL; FAMILY-HISTORY; CHRONIC STRESS; OBESITY;
   CHILDREN; ADOLESCENTS
AB Objective: Cortisol has been associated with preferential visceral adipose tissue (VAT) deposition; however, findings in humans are mixed, which may be clarified when diet is considered.
   Design and Methods: Participants included 165 African-American and Latino, overweight adolescents (BMI% 97.2 +/- 3.2%, ages 13-18, 67% Latino, 66% female). Body composition was determined by dual energy X-ray absorptiometry, abdominal fat depots [VAT, subcutaneous (SAT)] by multiple-slice MRI, time-controlled serum sample to measure cortisol, and 2-day multi-pass 24-hour dietary recall. Linear regression analysis examined the cross-sectional relationship between cortisol, and the interaction of diet and cortisol on adiposity measures. Sex, race, age, and total body fat were a priori covariates.
   Results: There was a significant interaction between cortisol and sugar (total and added) in the prediction of VAT (P-interaction <= 0.05). Amongst participants with high total or added-sugar intake, cortisol was significantly associated with VAT (beta = 0.031 P < 0.001; beta = 0.026 P < 0.001), with no relationship in low consumers of total or added-sugar.
   Conclusion: Dietary sugar may play an important role in modifying the relationship between cortisol and VAT, such that cortisol is significantly associated with elevated VAT under conditions of high sugar intake.
C1 [Gyllenhammer, Lauren E.; Weigensberg, Marc J.; Spruijt-Metz, Donna; Allayee, Hooman; Goran, Michael I.] Univ So Calif, Dept Prevent Med, Diabet & Obes Res Inst, Los Angeles, CA 90089 USA.
   [Davis, Jaimie N.] Univ Texas Austin, Dept Nutr Sci, Austin, TX 78712 USA.
C3 University of Southern California; University of Texas System;
   University of Texas Austin
RP Gyllenhammer, LE (corresponding author), Univ So Calif, Dept Prevent Med, Diabet & Obes Res Inst, Los Angeles, CA 90089 USA.
EM gyllenha@usc.edu
RI Davis, Jaimie/AAU-7800-2021
OI Gyllenhammer, Lauren/0000-0003-4338-8984
FU National Cancer Institute [U54CA116848]; National Institute of Child
   Health and Human Development [R01HD0033064]; Office of Minority Health
   [1P60MD002254-03]; National Institute of Diabetes and Digestive and
   Kidney Disease [1K01DK078858]; USC Graduate Provost Fellowship
FX This work was supported by the following: Grants: U54CA116848 from the
   National Cancer Institute, R01HD0033064 from the National Institute of
   Child Health and Human Development, 1P60MD002254-03 from the Office of
   Minority Health, 1K01DK078858 from the National Institute of Diabetes
   and Digestive and Kidney Disease, and USC Graduate Provost Fellowship.
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NR 39
TC 6
Z9 8
U1 0
U2 11
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1930-7381
EI 1930-739X
J9 OBESITY
JI Obesity
PD FEB
PY 2014
VL 22
IS 2
BP 474
EP 481
DI 10.1002/oby.20594
PG 8
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA AC0ZO
UT WOS:000332224200022
PM 23929660
OA Bronze, Green Accepted
DA 2025-06-11
ER

PT J
AU Hayes, EK
   Lechowicz, A
   Petrik, JJ
   Storozhuk, Y
   Paez-Parent, S
   Dai, Q
   Samjoo, IA
   Mansell, M
   Gruslin, A
   Holloway, AC
   Raha, S
AF Hayes, Emily K.
   Lechowicz, Anna
   Petrik, Jim J.
   Storozhuk, Yaryna
   Paez-Parent, Sabrina
   Dai, Qin
   Samjoo, Imtiaz A.
   Mansell, Margaret
   Gruslin, Andree
   Holloway, Alison C.
   Raha, Sandeep
TI Adverse Fetal and Neonatal Outcomes Associated with a Life-Long High Fat
   Diet: Role of Altered Development of the Placental Vasculature
SO PLOS ONE
LA English
DT Article
ID MATERNAL OBESITY; OXIDATIVE STRESS; INSULIN-RESISTANCE; METABOLIC
   SYNDROME; PREGNANCY; MODEL; FEMALE; BIRTH; RISK; WEIGHT
AB Maternal obesity results in a number of obstetrical and fetal complications with both immediate and long-term consequences. The increased prevalence of obesity has resulted in increasing numbers of women of reproductive age in this high-risk group. Since many of these obese women have been subjected to hypercaloric diets from early childhood we have developed a rodent model of life-long maternal obesity to more clearly understand the mechanisms that contribute to adverse pregnancy outcomes in obese women. Female Sprague Dawley rats were fed a control diet (CON - 16% of calories from fat) or high fat diet (HF - 45% of calories from fat) from 3 to 19 weeks of age. Prior to pregnancy HF-fed dams exhibited significant increases in body fat, serum leptin and triglycerides. A subset of dams was sacrificed at gestational day 15 to evaluate fetal and placental development. The remaining animals were allowed to deliver normally. HF-fed dams exhibited a more than 3-fold increase in fetal death and decreased neonatal survival. These outcomes were associated with altered vascular development in the placenta, as well as increased hypoxia in the labyrinth. We propose that the altered placental vasculature may result in reduced oxygenation of the fetal tissues contributing to premature demise and poor neonatal survival.
C1 [Hayes, Emily K.; Lechowicz, Anna; Storozhuk, Yaryna; Paez-Parent, Sabrina; Dai, Qin; Samjoo, Imtiaz A.; Mansell, Margaret; Raha, Sandeep] McMaster Univ, Dept Pediat, Hamilton, ON, Canada.
   [Hayes, Emily K.; Lechowicz, Anna; Samjoo, Imtiaz A.; Raha, Sandeep] McMaster Univ, Grad Program Med Sci, Hamilton, ON, Canada.
   [Petrik, Jim J.] Univ Guelph, Dept Biomed Sci, Guelph, ON N1G 2W1, Canada.
   [Gruslin, Andree] Univ Ottawa, Ottawa Hosp Res Inst, Dept Obstet & Gynecol, Div Maternal Fetal Med, Ottawa, ON, Canada.
   [Gruslin, Andree] Univ Ottawa, Ottawa Hosp Res Inst, Dept Cellular & Mol Med, Ottawa, ON, Canada.
   [Holloway, Alison C.] McMaster Univ, Dept Obstet & Gynecol, Hamilton, ON, Canada.
C3 McMaster University; McMaster University; University of Guelph;
   University of Ottawa; Ottawa Hospital Research Institute; University of
   Ottawa; Ottawa Hospital Research Institute; McMaster University
RP Hayes, EK (corresponding author), McMaster Univ, Dept Pediat, Hamilton, ON, Canada.
EM rahas@mcmaster.ca
RI Raha, Sandeep/AAF-3655-2020
OI Raha, Sandeep/0000-0001-7307-3292
FU Joint Funding-Sick Kids Foundation/CIHR [XG09-45R]; McMaster University
   [2007h00407]; Hamilton Health Sciences, New Investigator Fund [N08-175]
FX The funding sources for this submission are Joint Funding-Sick Kids
   Foundation/CIHR (#XG09-45R), McMaster University Start-up Funding
   (#2007h00407), and Hamilton Health Sciences, New Investigator Fund
   (#N08-175). The funders had no role in study design, data collection and
   analysis, decision to publish, or preparation of the manuscript.
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NR 60
TC 102
Z9 109
U1 0
U2 17
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAR 19
PY 2012
VL 7
IS 3
AR e33370
DI 10.1371/journal.pone.0033370
PG 12
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 939TA
UT WOS:000303836500027
PM 22442686
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Zhu, YM
   Luo, TM
   Jobin, C
   Young, HA
AF Zhu, Yuanmin
   Luo, T. Michelle
   Jobin, Christian
   Young, Howard A.
TI Gut microbiota and probiotics in colon tumorigenesis
SO CANCER LETTERS
LA English
DT Review
DE Microbiota; Inflammation; Probiotics; Colorectal cancer
ID LACTOBACILLUS-RHAMNOSUS; INTESTINAL MICROBIOTA; ANTITUMOR-ACTIVITY;
   ESCHERICHIA-COLI; RESISTANT STARCH; IN-VIVO; CANCER; INFLAMMATION;
   MICROFLORA; EXPRESSION
AB The human gastrointestinal tract harbors a complex and abundant microbial community reaching as high as 10(13)-10(14) microorganisms in the colon. This endogenous microbiota forms a symbiotic relationship with their eukaryotic host and this close partnership helps maintain homeostasis by performing essential and non-redundant tasks (e.g. nutrition/energy and, immune system balance, pathogen exclusion). Although this relationship is essential and beneficial to the host, various events (e.g. infection, diet, stress, inflammation) may impact microbial composition, leading to the formation of a dysbiotic microbiota, further impacting on health and disease states. For example, Crohn's disease and ulcerative colitis, collectively termed inflammatory bowel diseases (IBD), have been associated with the establishment of a dysbiotic microbiota. In addition, extra-intestinal disorders such as obesity and metabolic syndrome are also associated with the development of a dysbiotic microbiota. Consequently, there is an increasing interest in harnessing the power of the microbiome and modulating its composition as a means to alleviate intestinal pathologies/disorders and maintain health status. In this review, we will discuss the emerging relationship between the microbiota and development of colorectal cancer as well as present evidence that microbial manipulation (probiotic, prebiotic) impacts disease development. Published by Elsevier Ireland Ltd.
C1 [Young, Howard A.] Natl Canc Inst, Ctr Canc Res, Canc & Inflammat Program, Expt Immunol Lab, Frederick, MD 21702 USA.
   [Zhu, Yuanmin] Beijing Univ, Peoples Hosp, Dept Digest Dis, Beijing 100871, Peoples R China.
   [Jobin, Christian] Univ N Carolina, Div Gastroenterol & Hepatol, Chapel Hill, NC USA.
   [Luo, T. Michelle] US FDA, CDRH, OIVD, Silver Spring, MD USA.
C3 National Institutes of Health (NIH) - USA; NIH National Cancer Institute
   (NCI); Peking University; University of North Carolina; University of
   North Carolina Chapel Hill; US Food & Drug Administration (FDA)
RP Young, HA (corresponding author), Natl Canc Inst, Ctr Canc Res, Canc & Inflammat Program, Expt Immunol Lab, Bldg 560-31-23,Chandler St, Frederick, MD 21702 USA.
EM YoungHow@mail.nih.gov
RI Young, Howard/R-5140-2019; Young, Howard/A-6350-2008
OI Young, Howard/0000-0002-3118-5111
FU NIH [HHSN261200800001E]; National Cancer Institute; Center for Cancer
   Research
FX This work was supported by the Intramural Research Program of the NIH,
   National Cancer Institute, Center for Cancer Research. This project has
   been funded with federal funds from the National Cancer Institute, NIH,
   under contract HHSN261200800001E.
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NR 76
TC 165
Z9 201
U1 1
U2 105
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0304-3835
EI 1872-7980
J9 CANCER LETT
JI Cancer Lett.
PD OCT 28
PY 2011
VL 309
IS 2
BP 119
EP 127
DI 10.1016/j.canlet.2011.06.004
PG 9
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA 816CN
UT WOS:000294576400001
PM 21741763
OA Green Accepted, Green Submitted
DA 2025-06-11
ER

PT J
AU Johnson, RJ
   Lanaspa, MA
   Gaucher, EA
AF Johnson, Richard J.
   Lanaspa, Miguel A.
   Gaucher, Eric A.
TI Uric Acid: A Danger Signal From the RNA World That May Have a Role in
   the Epidemic of Obesity, Metabolic Syndrome, and Cardiorenal Disease:
   Evolutionary Considerations
SO SEMINARS IN NEPHROLOGY
LA English
DT Review
DE Uricase; fructose; thrifty gene; anti-oxidant; oxidant; RNA world
ID HEREDITARY FRUCTOSE INTOLERANCE; SERUM ANTIOXIDANT CAPACITY; INDUCED
   OXIDATIVE STRESS; URATE OXIDASE; NITRIC-OXIDE; INDEPENDENT PREDICTOR;
   PARKINSONS-DISEASE; CELL-PROLIFERATION; INCREASE; BLOOD
AB All human beings are uricase knockouts; we lost the uricase gene as a result of a mutation that occurred in the mid-Miocene epoch approximately 15 million years ago. The consequence of being a uricase knockout is that we have higher serum uric acid levels that are less regulatable and can be readily influenced by diet. This increases our risk for gout and kidney stones, but there is also increasing evidence that uric acid increases our risk for hypertension, kidney disease, obesity, and diabetes. This raises the question of why this mutation occurred. In this article we review current hypotheses. We suggest that uric acid is a danger and survival signal carried over from the RNA world. The mutation of uricase that occurred during the food shortage and global cooling that occurred in the Miocene epoch resulted in a survival advantage for early primates, particularly in Europe. Today, the loss of uricase functions as a thrifty gene, increasing our risk for obesity and cardiorenal disease. Semin Nephrol 31:394-399 (C) 2011 Elsevier Inc. All rights reserved.
C1 [Johnson, Richard J.; Lanaspa, Miguel A.] Univ Colorado Denver, Div Renal Dis & Hypertens, Aurora, CO 80045 USA.
   [Gaucher, Eric A.] Georgia Inst Technol, Sch Biol, Atlanta, GA 30332 USA.
C3 University of Colorado System; University of Colorado Anschutz Medical
   Campus; Children's Hospital Colorado; University System of Georgia;
   Georgia Institute of Technology
RP Johnson, RJ (corresponding author), Univ Colorado Denver, Div Renal Dis & Hypertens, 12700 E 19th Ave,Room 7015, Aurora, CO 80045 USA.
EM richard.johnson@ucdenver.edu
RI Gaucher, Eric/I-7313-2013; Lanaspa, Miguel/AAO-4971-2020
FU National Institutes of Health [HL-68607]
FX Support for this article was provided by National Institutes of Health
   grant HL-68607. Richard Johnson and Miguel Lanaspa are listed as
   inventors on patent applications to decrease uric acid or block fructose
   metabolism as a means for treating obesity and metabolic syndrome or
   related conditions.
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NR 79
TC 99
Z9 108
U1 2
U2 39
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0270-9295
EI 1558-4488
J9 SEMIN NEPHROL
JI Semin. Nephrol.
PD SEP
PY 2011
VL 31
IS 5
BP 394
EP 399
DI 10.1016/j.semnephrol.2011.08.002
PG 6
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 841BJ
UT WOS:000296486700002
PM 22000645
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Moko, EM
   Rawung, LD
   Rahardiyan, D
   Lihiang, A
AF Moko, Emma Mauren
   Rawung, Livana Dethris
   Rahardiyan, Dino
   Lihiang, Anatje
TI Resistant starch type 1 and 2 macromolecules from giant swamp taro
   (Cyrtosperma merkusii): A potential solution for lipid
   metabolism-regulating strategies
SO INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
LA English
DT Article
DE Cyrtosperma merkusii; Giant swamp taro; Lipid metabolism; Resistant
   starch
AB Liver lipid management is a recognized strategy for the treatment and prevention of degenerative diseases and metabolic syndrome. Giant swamp taro (GST) starches are biomolecules extracted from GST (Cyrtosperma merkusii) sourced from Sangihe Island, North Sulawesi, Indonesia. GST contains naturally occurring resistant starch types 1 and 2. GST starch was characterized by observing its structural compositions, crystallinity structure, and granule microstructure using Fourier transform infrared spectroscopy, X-ray diffraction, and scanning electron microscopy, respectively, which confirmed the extracted starch macromolecule and natural presence of resistant starch in GST. GST starch was fed to male Sprague-Dawley rats (Rattus norvegicus) induced with a high-fat diet (HFD). These rats were compared to a normal group fed a ruminant feed, a negative control group fed only an HFD, a group administered glibenclamide, and a group administered simvastatin. The results showed that GST starch has a positive impact on oxidative stress and lipid metabolism regulation. In terms of hepatoprotective activity, GST was more closely associated with lipid regulation than with sugar metabolism, as indicated by its stronger correlation with simvastatin than with glibenclamide. The resistant starch in GST is likely involved in the regulation of gut microbiota composition; however, this mechanism has yet to be confirmed.
C1 [Moko, Emma Mauren; Rawung, Livana Dethris] Manado State Univ, Fac Math Nat Sci & Earth, Biol Dept, Tondano 95618, North Sulawesi, Indonesia.
   [Rahardiyan, Dino] Univ Catholic La Salle Manado, Fac Agr, Agribussiness Dept, Manado 95253, North Sulawesi, Indonesia.
   [Rahardiyan, Dino] Catholic Univ La Salle Manado, La Salle Sustainabill Ctr, Manado 95253, North Sulawesi, Indonesia.
   [Lihiang, Anatje] Manado State Univ, Fac Math Nat Sci & Earth, Biol Educ Dept, Tondano 95618, North Sulawesi, Indonesia.
C3 Universitas Negeri Manado; Universitas Negeri Manado
RP Moko, EM (corresponding author), Manado State Univ, Fac Math Nat Sci & Earth, Biol Dept, Tondano 95618, North Sulawesi, Indonesia.
EM emmamoko@unima.ac.id; livanarawung@unima.ac.id;
   drahardiyan@unikadelasalle.ac.id; anatjelihiang@unima.ac.id
FU National Competitive Grants; Fundamental Research (PFR) [2024,
   067/E5/PG.02.00, PL/2024]
FX This research is supported by the Directorate of Research, Technology
   and Community Services (DRTPM) , Ministry of Education, Culture,
   Research, and Technology (KEMDIKBUDRISTEK, Indonesia) through National
   Competitive Grants, Fundamental Research (PFR) 2024 grant (contract
   number 067/E5/PG.02.00.PL/2024) .r National Competitive Grants,
   Fundamental Research (PFR) 2024 grant (contract number
   067/E5/PG.02.00.PL/2024) .
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NR 34
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0141-8130
EI 1879-0003
J9 INT J BIOL MACROMOL
JI Int. J. Biol. Macromol.
PD JUN
PY 2025
VL 312
AR 144193
DI 10.1016/j.ijbiomac.2025.144193
PG 15
WC Biochemistry & Molecular Biology; Chemistry, Applied; Polymer Science
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry; Polymer Science
GA 2XW5Z
UT WOS:001493919200002
PM 40373893
DA 2025-06-11
ER

PT J
AU Ding, Q
   Wen, K
   Li, Q
   Zhao, QH
   Zhao, JL
   Xiao, YF
   Guan, XH
   Jiang, MX
   Zhang, F
   Wang, LF
AF Ding, Qi
   Wen, Ke
   Li, Qian
   Zhao, Qi-Hang
   Zhao, Jia-Le
   Xiao, Yun-Fei
   Guan, Xiao-Hui
   Jiang, Mei-Xiu
   Zhang, Feng
   Wang, Ling -Fang
TI CD38 deficiency promotes skeletal muscle and brown adipose tissue energy
   expenditure through activating NAD<SUP>+</SUP>-Sirt1-PGC1α signaling
   pathway
SO CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
LA English
DT Article
DE CD38; Sirt1; energy expenditure; PGC1 & alpha;
ID MITOCHONDRIAL; METABOLISM; OBESITY
AB Obesity is a metabolic syndrome characterized by abnormal lipid deposition and energy imbalance. CD38 is a single-chain transmembrane glycoprotein widely expressed in a variety of cell types. The roles of skeletal muscle and brown fat in CD38 deficiency under HFD-induced obesity remain unknown. In this study, we established obesity model with HFD and examined the changes in metabolites with metabonomics. Our results showed that CD38 expression was increased in muscle and brown fat after HFD treatment. Moreover, the results of metabonomics showed that CD38 deficiency significantly altered the metabolites in energy metabolism, cofactor generation, and redox homeostasis. Furthermore, CD38 deficiency reduced the expressions of NADPH oxidase 2 and FASN in mRNA level. We found that the expressions of Sirt1, Sirt3, and PGC1a were upregulated in CD38-deficient muscle tissue. In brown fat, the Sirt1-3, cell death inducing DFFA-like effector A, ELOVL3, and Dio2 expressions were increased in CD38-deficient mice. Our results showed the uncoupling protein 1 expression was upregulated. And NAD+ supplementation increased the expression of Sirt1 and PGC1a after palmitic acid treatment. Taken together, our results demonstrated that the protection of CD38 deficiency on HFD-induced obesity was related to the inhibition of oxidative stress and increasing energy expenditure via activating NAD(+)/Sirtuins signaling pathways in muscle and brown fat.
C1 [Ding, Qi; Wen, Ke; Li, Qian; Zhao, Qi-Hang; Zhao, Jia-Le; Xiao, Yun-Fei; Guan, Xiao-Hui; Jiang, Mei-Xiu; Zhang, Feng; Wang, Ling -Fang] Nanchang Univ, Inst Translat Med, Natl Engn Res Ctr Bioengn Drugs & Technol, Nanchang 330031, Peoples R China.
C3 Nanchang University
RP Wang, LF (corresponding author), Nanchang Univ, Inst Translat Med, Natl Engn Res Ctr Bioengn Drugs & Technol, Nanchang 330031, Peoples R China.
EM wlfang1985@ncu.edu.cn
RI zhang, feng/L-2587-2013; Qihang, Zhao/AAX-7897-2021
FU National Natural Science Foundation of China [82000354]; Natural Science
   Founda-tion of Jiangxi Province [20212BAB206087, 20212BCJ23043,
   20212BAB216077, 20212BDH81020]; National Nat-ural Science Foundation of
   China [81970256, 82260173, 82200509, 82160094]
FX This work was supported by the National Natural Science Foundation of
   China (82000354) , the Natural Science Founda-tion of Jiangxi Province
   (20212BAB206087, 20212BCJ23043, 20212BAB216077, 20212BDH81020) , and the
   National Nat-ural Science Foundation of China (81970256, 82260173,
   82200509, 82160094) .
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NR 41
TC 3
Z9 3
U1 6
U2 16
PU CANADIAN SCIENCE PUBLISHING
PI OTTAWA
PA 123 Slater Street, Suite 610, OTTAWA, ON K1P 5H2, CANADA
SN 0008-4212
EI 1205-7541
J9 CAN J PHYSIOL PHARM
JI Can. J. Physiol. Pharmacol.
PD JUL
PY 2023
VL 101
IS 7
BP 369
EP 381
DI 10.1139/cjpp-2022-0454369
PG 13
WC Pharmacology & Pharmacy; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Physiology
GA L6LN2
UT WOS:001024358700005
PM 37192549
DA 2025-06-11
ER

PT J
AU Mornagui, B
   Rezg, R
   Repond, C
   Pellerin, L
AF Mornagui, Bessem
   Rezg, Raja
   Repond, Cendrine
   Pellerin, Luc
TI Bisphenol S favors hepatic steatosis development via an upregulation of
   liver MCT1 expression and an impairment of the mitochondrial respiratory
   system
SO JOURNAL OF CELLULAR PHYSIOLOGY
LA English
DT Article
DE bisphenol S; mitochondrial function; monocarboxylate transporters;
   steatosis
ID MONOCARBOXYLATE TRANSPORTERS; NEUROENDOCRINE DISRUPTION; LACTATE
   METABOLISM; INSULIN-RESISTANCE; LACTIC-ACID; BODY-WEIGHT; FOOD-INTAKE;
   SHORT-TERM; EXPOSURE; ASSAY
AB Bisphenol S (BPS) is a common substitute of bisphenol A (BPA). Recent data suggest that BPS acts as an obesogenic endocrine disruptor with emerging implications in the physiopathology of metabolic syndrome. However, the effects of BPS on monocarboxylate transporters (acting as carriers for lactate, pyruvate, and ketone bodies) and the mitochondrial respiratory system in the liver remain limited. For this purpose, male Swiss mice were treated with BPS at 100 mu g/kg/day for 10 weeks, in drinking water. An increase in body weight and food intake was observed with no increase in locomotor activity. Moreover, data show that BPS increases hepatic MCT1 (a key energetic fuel transporter) mRNA expression accompanied by hepatic steatosis initiation and lipid accumulation, while disrupting mitochondrial function and oxidative stress parameters. Furthermore, BPS produced a significant increase in lactate dehydrogenase and creatine kinase activities. We can suggest that BPS contributes to hepatic steatosis in mice by upregulating monocarboxylate transporters and affecting the bioenergetic status characterized by an impaired mitochondrial respiratory system. Thus, our data highlight a new mechanism putatively implicated in hepatic steatosis development during BPS-induced obesity involving lactate metabolism.
C1 [Mornagui, Bessem] Univ Gabes, Fac Sci Gabes, Gabes, Tunisia.
   Univ Monastir, Higher Inst Biotechnol Monastir, Monastir, Tunisia.
   Univ Lausanne, Dept Physiol, Lausanne, Switzerland.
   Univ CHU Poitiers, Inserm U1313, Fac Med & Pharm, Poitiers, France.
   Univ Gabes, Fac Sci Gabes, Dept Life Sci, Gabes 6072, Tunisia.
C3 Universite de Gabes; Universite de Monastir; University of Lausanne;
   Institut National de la Sante et de la Recherche Medicale (Inserm);
   Universite de Poitiers; Universite de Gabes
RP Mornagui, B (corresponding author), Univ Gabes, Fac Sci Gabes, Gabes, Tunisia.
EM bessem.mornagui@gmail.com
RI Pellerin, Luc/HJB-1376-2022; mornagui, bessem/KDN-3996-2024; Pellerin,
   Luc/A-8912-2017
OI Pellerin, Luc/0000-0002-1016-1970; Mornagui, Bessem/0000-0002-2318-5787;
   Rezg, Raja/0000-0002-6066-8139
FU Tunisian Ministry of Higher Education and Scientific Research;
   Department of Physiology, University of Lausanne; program IdEx Bordeaux
   [ANR-10-IDEX-03-02]
FX This study was supported by the Tunisian Ministry of Higher Education
   and Scientific Research. LP received financial support from the
   Department of Physiology, University of Lausanne and from the program
   IdEx Bordeaux ANR-10-IDEX-03-02. The authors thank particularly Pr.
   Tsuyoshi Miyakawa of Institute for Comprehensive Medical Science, Fujita
   Health University (Japan).
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NR 74
TC 8
Z9 8
U1 1
U2 13
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0021-9541
EI 1097-4652
J9 J CELL PHYSIOL
JI J. Cell. Physiol.
PD JUL
PY 2022
VL 237
IS 7
BP 3057
EP 3068
DI 10.1002/jcp.30771
EA MAY 2022
PG 12
WC Cell Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Physiology
GA 2V5DB
UT WOS:000794905900001
PM 35561261
DA 2025-06-11
ER

PT J
AU Liu, JR
   Fan, DM
   Wang, X
   Yin, FZ
AF Liu, Junru
   Fan, Dongmei
   Wang, Xing
   Yin, Fuzai
TI Association of two novel adiposity indicators with visceral fat area in
   type 2 diabetic patients Novel adiposity indexes for type 2 diabetes
SO MEDICINE
LA English
DT Article
DE adiposity indicator; type 2 diabetes; visceral fat area
ID METABOLIC SYNDROME; ANTHROPOMETRIC INDEXES; INSULIN-RESISTANCE;
   OXIDATIVE STRESS; OBESITY; PREDICTION; OVERWEIGHT; DISEASE; RISK
AB The present study evaluated the performance of 2 novel adiposity indicators, body shape index (ABSI), and body roundness index (BRI), to determine the accumulation of visceral fat in type 2 diabetic patients. A cross-sectional study was performed on 233 type 2 diabetic patients from Qinhuangdao, China. Visceral fat area (VFA) was measured using bioelectrical impedance. Accumulation of visceral fat was defined as VFA >= 100 cm(2). In diabetic males, the area under the curve (AUC) values were 0.904 for waist circumference (WC), 0.923 for BRI, and 0.788 for ABSI. In diabetic females, the AUC values were 0.894 for WC, 0.915 for BRI, and 0.668 for ABSI. The AUCs were similar between BRI and WC (P > .05). The AUC for ABSI was lower compared to WC and BRI (P < .05). The optimal cut-off for BRI was 4.25 for diabetic males (sensitivity = 87.8% and specificity = 81.1%) and 4.75 for diabetic females (sensitivity = 80.8% and specificity = 88.1%). BRI was an effective indicator for determining the accumulation of visceral fat in type 2 diabetic patients, however, it was not better compared to WC.
C1 [Liu, Junru; Fan, Dongmei; Wang, Xing; Yin, Fuzai] First Hosp Qinhuangdao, Dept Endocrinol, 258 Wenhua Rd, Qinhuangdao 066000, Hebei, Peoples R China.
RP Yin, FZ (corresponding author), First Hosp Qinhuangdao, Dept Endocrinol, 258 Wenhua Rd, Qinhuangdao 066000, Hebei, Peoples R China.
EM yinfu_zai@163.com
CR Amer Diabet Assoc, 2010, DIABETES CARE, V33, pS11, DOI [10.2337/dc10-S011, 10.2337/dc10-S062, 10.2337/dc13-S011, 10.2337/dc13-S067, 10.2337/dc11-S011, 10.2337/dc14-S081, 10.2337/dc12-s064, 10.2337/dc11-S062, 10.2337/dc12-s011]
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NR 26
TC 19
Z9 19
U1 0
U2 9
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD MAY
PY 2020
VL 99
IS 19
AR e20046
DI 10.1097/MD.0000000000020046
PG 4
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA MO4NN
UT WOS:000551504800043
PM 32384466
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Ghaffari, S
   Roshanravan, N
AF Ghaffari, Samad
   Roshanravan, Neda
TI Saffron; An updated review on biological properties with special focus
   on cardiovascular effects
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Review
DE Cardiovascular disease; Saffron; Carotenoids; Antioxidant
ID CROCUS-SATIVUS-L.; TRANS-SODIUM CROCETINATE; OXIDATIVE STRESS; METABOLIC
   SYNDROME; IN-VITRO; EXPERIMENTAL ATHEROSCLEROSIS; INFLAMMATORY RESPONSE;
   GARDENIA-JASMINOIDES; SMOOTH-MUSCLE; RISK-FACTOR
AB Objective: Saffron as a natural product has long been used to impede and treat different disorders including cardiovascular disease (CVDs). Stigma is the most principal part of saffron. Various compounds such as carotenoids and flavonoids are the essential components of saffron stigma. The health benefits of saffron have been shown in previous studies; however, there is a lack of comprehensive data on the mechanistic aspects of its cardiovascular-health properties. This current comprehensive review focuses on the medicinal applications of saffron, and then the new findings regarding its cardiovascular-health effects and various cellular and molecular mechanisms of action will be debated.
   Methods: The literature search of MEDLINE, Embase, PubMed, Google Scholar and Cochrane Library was performed for all comparative studies since 2000-2018 with the limitations of the English language.
   Results: The results provided new evidence about antioxidant, anti- inflammatory, anti-atherogenic, antiapoptotic, anti-hypertensive, and hypolipidemic effects of saffron. Pharmacological effects of saffron are due to a number of ingredients contained within this spice, including safranal, crocetin and crocins.
   Conclusions: Our study concludes that saffron with wide range of usefulness in medicine may be the potent candidate in the process of new drug production for the treatment of CVDs.
C1 [Ghaffari, Samad; Roshanravan, Neda] Tabriz Univ Med Sci, Cardiovasc Res Ctr, Tabriz, Iran.
C3 Tabriz University of Medical Science
RP Roshanravan, N (corresponding author), Tabriz Univ Med Sci, Cardiovasc Res Ctr, Tabriz, Iran.
EM ghafaris@gmail.com; roshanravann@tbzmed.ac.ir
OI Roshanravan, Neda/0000-0002-8173-6532; Ghaffari,
   Samad/0000-0001-6806-9387
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NR 100
TC 117
Z9 121
U1 3
U2 51
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD JAN
PY 2019
VL 109
BP 21
EP 27
DI 10.1016/j.biopha.2018.10.031
PG 7
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA HD5AE
UT WOS:000452539100002
PM 30391705
OA gold
DA 2025-06-11
ER

PT J
AU Guidotti, S
   Minguzzi, M
   Platano, D
   Santi, S
   Trisolino, G
   Filardo, G
   Mariani, E
   Borzì, RM
AF Guidotti, S.
   Minguzzi, M.
   Platano, D.
   Santi, S.
   Trisolino, G.
   Filardo, G.
   Mariani, E.
   Borzi, R. M.
TI Glycogen Synthase Kinase-3β Inhibition Links Mitochondrial Dysfunction,
   Extracellular Matrix Remodelling and Terminal Differentiation in
   Chondrocytes
SO SCIENTIFIC REPORTS
LA English
DT Article
ID CARTILAGE DEGRADATION; METABOLIC SYNDROME; LITHIUM PROTECTS; II
   COLLAGEN; STEM-CELLS; ACTIVATION; BETA; HYPERTROPHY; METALLOPROTEINASES;
   OSTEOARTHRITIS
AB Following inflammatory stimuli, GSK3 inhibition functions as a hub with pleiotropic effects leading to cartilage degradation. However, little is known about the effects triggered by its direct inhibition as well as the effects on mitochondrial pathology, that contributes to osteoarthritis pathogenesis. To this aim we assessed the molecular mechanisms triggered by GSK3 beta inactivating stimuli on 3-D (micromass) cultures of human articular chondrocytes. Stimuli were delivered either at micromass seeding (long term) or after maturation (short term) to explore "late" effects on terminal differentiation or "early" mitochondrial effects, respectively. GSK3 beta inhibition significantly enhanced mitochondrial oxidative stress and damage and endochondral ossification based on increased nuclear translocation of Runx-2 and beta-catenin, calcium deposition, cell death and enhanced remodelling of the extracellular matrix as demonstrated by the increased collagenolytic activity of supernatants, despite unmodified (MMP-1) or even reduced (MMP-13) collagenase gene/protein expression. Molecular dissection of the underlying mechanisms showed that GSK3 beta inhibition achieved with pharmacological/silencing strategies impacted on the control of collagenolytic activity, via both decreased inhibition (reduced TIMP-3) and increased activation (increased MMP-10 and MMP-14). To conclude, the inhibition of GSK3 beta enhances terminal differentiation via concerted effects on ECM and therefore its activity represents a tool to keep articular cartilage homeostasis.
C1 [Guidotti, S.; Minguzzi, M.; Platano, D.; Mariani, E.; Borzi, R. M.] Ist Ortoped Rizzoli, Lab Immunoreumatol & Rigeneraz Tessutale, Bologna, Italy.
   [Guidotti, S.; Minguzzi, M.; Platano, D.; Mariani, E.] Univ Bologna, Dipartimento Sci Mat & Chirurg, Bologna, Italy.
   [Santi, S.] Ist Ortoped Rizzoli, CNR, Ist Genet Mol, Lab Biol Cellulare Muscoloscheletr, Bologna, Italy.
   [Trisolino, G.] Ist Ortoped Rizzoli, Chirurg Ricostrutt Articolare Anca & Ginocchio, Bologna, Italy.
   [Filardo, G.] Ist Ortoped Rizzoli, Clin Ortoped & Traumatol 2, Lab NanoBiotecnol, Bologna, Italy.
C3 IRCCS Istituto Ortopedico Rizzoli; University of Bologna; IRCCS Istituto
   Ortopedico Rizzoli; Consiglio Nazionale delle Ricerche (CNR); Istituto
   di Genetica Molecolare (IGM-CNR); IRCCS Istituto Ortopedico Rizzoli;
   IRCCS Istituto Ortopedico Rizzoli
RP Borzì, RM (corresponding author), Ist Ortoped Rizzoli, Lab Immunoreumatol & Rigeneraz Tessutale, Bologna, Italy.
RI Minguzzi, Manuela/J-8172-2017; Borzì, Rosa/ABI-2279-2020; Trisolino,
   Giovanni/I-3717-2019; Platano, Daniela/GLU-1392-2022; Mariani,
   Erminia/AAE-8110-2021; Santi, Spartaco/Q-7587-2016; Mariani,
   Erminia/C-6881-2019
OI platano, daniela/0000-0001-7923-4114; Santi,
   Spartaco/0000-0001-9856-7053; Mariani, Erminia/0000-0002-4407-6707;
   Borzi, Rosa Maria/0000-0003-4133-4894; Trisolino,
   Giovanni/0000-0002-0361-9920
FU FIRB (Ministero dell'istruzione, dell'Universita e della Ricerca, Italy)
   [RBAP10KCNS]; Fondi cinque per mille (Ministero della Salute, Italy)
FX This work was supported by FIRB (Ministero dell'istruzione,
   dell'Universita e della Ricerca, Italy) grant RBAP10KCNS and Fondi
   cinque per mille (Ministero della Salute, Italy).
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NR 58
TC 30
Z9 33
U1 0
U2 8
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD SEP 21
PY 2017
VL 7
AR 12059
DI 10.1038/s41598-017-12129-5
PG 14
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA FH8BK
UT WOS:000411416600016
PM 28935982
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Lin, CC
   Wang, YP
   Lee, KS
   Liaw, SF
   Chiu, CH
AF Lin, Ching-Chi
   Wang, Ying-Piao
   Lee, Kuo-Sheng
   Liaw, Shwu-Fang
   Chiu, Chung-Hsin
TI Effect of Uvulopalatopharyngoplasty on Leptin and Endothelial Function
   in Sleep Apnea
SO ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
LA English
DT Article
DE endothelial function; leptin; nitric oxide derivative; obstructive sleep
   apnea syndrome; uvulopalatopharyngoplasty
ID POSITIVE AIRWAY PRESSURE; METABOLIC SYNDROME; NITRIC-OXIDE;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; ADIPOCYTOKINES; ATHEROSCLEROSIS;
   ASSOCIATION; DYSFUNCTION; DISEASE
AB Objectives: This study evaluated the effects of uvulopalatopharyngoplasty (UPPP) on serum leptin levels and endothelial function in patients with obstructive sleep apnea syndrome (OSAS).
   Methods: Fifteen healthy subjects and 35 patients with moderate to severe OSAS who desired UPPP were prospectively enrolled. The serum levels of leptin and nitric oxide derivative (NOx) from their peripheral blood samples were measured by enzyme-linked immunosorbent assay. All subjects participated in sleep studies, which were repeated 3 months after UPPP in the patients with OSAS.
   Results: Before UPPP, the patients with OSAS had a higher serum level of leptin and a lower NOx level than did the control subjects. The serum leptin levels in the 17 of the 35 patients with OSAS who were surgical responders decreased from 24.2 +/- 6.1 ng/mL before operation to 15.9 +/- 6.0 ng/mL after operation. The serum NOx levels in these 17 patients increased from 18.5 +/- 7.5 mu mol/L before operation to 27.3 +/- 8.2 mu mol/L after operation. In the 18 patients who were unresponsive to surgery, the serum leptin and NOx levels remained impaired after the UPPP.
   Conclusions: Successful treatment of OSAS with UPPP leads to the normalization of serum leptin and NOx levels.
C1 [Lin, Ching-Chi] Mackay Mem Hosp, Dept Internal Med, Chest Div, Taipei, Taiwan.
   [Lin, Ching-Chi; Liaw, Shwu-Fang] Mackay Mem Hosp, Dept Med Res, Taipei, Taiwan.
   [Wang, Ying-Piao; Lee, Kuo-Sheng] Mackay Mem Hosp, Dept Otolaryngol, Taipei, Taiwan.
   [Lin, Ching-Chi; Chiu, Chung-Hsin] Mackay Mem Hosp, Sleep Ctr, Taipei, Taiwan.
   [Lin, Ching-Chi] Mackay Med Nursing & Management Coll, Dept Nursing, Taipei, Taiwan.
C3 Mackay Memorial Hospital; Mackay Memorial Hospital; Mackay Memorial
   Hospital; Mackay Memorial Hospital; Mackay Junior College of Medicine,
   Nursing & Management
RP Lin, CC (corresponding author), Mackay Mem Hosp, Dept Internal Med, Chest Div, 92 Sect 2,Chung Shan North Rd, Taipei, Taiwan.
RI Lee, Kuo-Sheng/A-7653-2017
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NR 27
TC 16
Z9 16
U1 0
U2 2
PU ANNALS PUBL CO
PI ST LOUIS
PA 4507 LACLEDE AVE, ST LOUIS, MO 63108 USA
SN 0003-4894
EI 1943-572X
J9 ANN OTO RHINOL LARYN
JI Ann. Otol. Rhinol. Laryngol.
PD JAN
PY 2014
VL 123
IS 1
BP 40
EP 46
DI 10.1177/0003489414521385
PG 7
WC Otorhinolaryngology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Otorhinolaryngology
GA AA0YM
UT WOS:000330823300006
PM 24574422
DA 2025-06-11
ER

PT J
AU Bozic, MA
   Subbarao, G
   Molleston, JP
AF Bozic, Molly A.
   Subbarao, Girish
   Molleston, Jean P.
TI Pediatric Nonalcoholic Fatty Liver Disease
SO NUTRITION IN CLINICAL PRACTICE
LA English
DT Review
DE pediatrics; liver diseases; obesity fatty liver; non-alcoholic fatty
   liver disease
ID OBSTRUCTIVE SLEEP-APNEA; OBESE CHILDREN; METABOLIC SYNDROME;
   AMINOTRANSFERASE LEVELS; INSULIN-RESISTANCE; HEPATIC STEATOSIS;
   RISK-FACTORS; CARDIOVASCULAR-DISEASE; LIPID-PEROXIDATION;
   PHYSICAL-ACTIVITY
AB Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in the pediatric population. Increased recognition of this form of liver disease parallels the dramatic rise in childhood and adolescent obesity over the past 2 decades. Like adults, most children with NAFLD are obese, and comorbidities include insulin resistance, hypertension, and dyslipidemia. Unfortunately, pediatric NAFLD is not always a benign condition, with some children progressing to hepatic fibrosis and even cirrhosis in severe cases. The etiology of nonalcoholic steatohepatitis is not yet fully understood; however, hepatic steatosis in the context of insulin resistance and increased oxidative stress may lead to progressive disease. Although physical examination, laboratory evaluation, and radiographic findings provide clues to the potential presence of fatty liver disease, liver biopsy remains the gold standard for diagnosis. Lifestyle modification, including slow and steady weight loss, improved dietary habits, and increased daily, aerobic physical activity, remains the first-line approach in treating pediatric fatty liver disease. Antioxidant pharmacologic therapy such as use of vitamin E has shown some benefit in patients with biopsy-proven steatohepatitis. Nutrition plays an essential role not only in the development of fatty liver disease but also potentially in the treatment and prevention of progression to more severe disease.
C1 [Bozic, Molly A.; Subbarao, Girish; Molleston, Jean P.] Indiana Univ Sch Med, Indianapolis, IN 46202 USA.
C3 Indiana University System; Indiana University Bloomington
RP Bozic, MA (corresponding author), Indiana Univ Sch Med, James Whitcomb Riley Hosp Children Pediat Gastroe, 705 Riley Hosp Dr,ROC 4210, Indianapolis, IN 46202 USA.
EM mbozic@iupui.edu
OI Bozic, Molly/0000-0002-3644-5381
FU National Institutes of Health UO1 grant
FX Dr Molleston received funding for nonalcoholic steatohepatitis clinical
   research through a National Institutes of Health UO1 grant.
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NR 87
TC 20
Z9 21
U1 1
U2 19
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0884-5336
EI 1941-2452
J9 NUTR CLIN PRACT
JI Nutr. Clin. Pract.
PD AUG
PY 2013
VL 28
IS 4
BP 448
EP 458
DI 10.1177/0884533613489153
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 196JU
UT WOS:000322771600004
PM 23917437
DA 2025-06-11
ER

PT J
AU Wang, XF
   Yue, M
AF Wang, Xiu-Fang
   Yue, Min
TI Relationship between alcohol consumption and clinical manifestation of
   patients with fatty liver: a single-center study
SO HEPATOBILIARY & PANCREATIC DISEASES INTERNATIONAL
LA English
DT Article
DE alcohol consumption; fatty liver; hemoglobin; aspartate transaminase;
   gamma-glutamyl transpeptidase
ID GAMMA-GLUTAMYL-TRANSFERASE; METABOLIC SYNDROME; GEOGRAPHICAL FACTORS;
   OXIDATIVE STRESS; URIC-ACID; DISEASE; HEMOGLOBIN; STEATOHEPATITIS;
   ASSOCIATION; POPULATION
AB BACKGROUND: Fatty liver is a common chronic liver disease worldwide. It is associated with an increasing morbidity in China in recent years. The aim of this study was to analyze the effect of drinking alcohol on the hemoglobin and biochemical values of patients with fatty liver.
   METHODS: We investigated the clinical and laboratory data of 669 patients with fatty liver. Of the 669 patients, 166 consumed alcohol more than 60 g per week for at least 2 years, and 503 did not have a history of long-term alcohol consumption. We further analyzed the relationship between alcohol consumption and clinical characteristics of these patients.
   RESULTS: The values of aspartate transaminase (AST), gamma-glutamyl transpeptidase (GGT), and hemoglobin in the long-term consumption group were significantly higher than those in the non long-term consumption group (P<0.05). In the patients without long-term alcohol consumption, the values of GGT and hemoglobin in patients with light alcohol consumption were significantly higher than those in non alcohol consumers (P<0.05).
   CONCLUSION: Alcohol consumption is associated with significantly increased values of AST, GGT, and hemoglobin in patients with fatty liver, suggesting their potential roles in hepatic steatosis.
C1 [Wang, Xiu-Fang] Zhejiang Univ, Sch Med, Affiliated Hosp 1, Int Hlth Care Ctr, Hangzhou 310003, Zhejiang, Peoples R China.
   [Yue, Min] Zhejiang Univ, Sch Med, Affiliated Hosp 1, Dept Gastroenterol, Hangzhou 310003, Zhejiang, Peoples R China.
C3 Zhejiang University; Zhejiang University
RP Wang, XF (corresponding author), Zhejiang Univ, Sch Med, Affiliated Hosp 1, Int Hlth Care Ctr, 79 Qingchun Rd, Hangzhou 310003, Zhejiang, Peoples R China.
EM wanqi1001@l63.com
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NR 16
TC 9
Z9 11
U1 0
U2 8
PU ZHEJIANG UNIV SCH MEDICINE
PI HANGZHOU
PA FIRST AFFILIATED HOSPITAL, 79 QINGCHUN ROAD, HANGZHOU, 310003, PEOPLES R
   CHINA
SN 1499-3872
J9 HEPATOB PANCREAT DIS
JI Hepatob. Pancreatic. Dis. Int.
PD JUN
PY 2011
VL 10
IS 3
BP 276
EP 279
DI 10.1016/S1499-3872(11)60046-5
PG 4
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 775KY
UT WOS:000291459400008
PM 21669571
DA 2025-06-11
ER

PT J
AU Amann, K
   Wanner, C
   Ritz, E
AF Amann, Kerstin
   Wanner, Christoph
   Ritz, Eberhard
TI Cross-talk between the kidney and the cardiovascular system
SO JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
LA English
DT Review
ID CIRCULATING ENDOTHELIAL-CELLS; MILD RENAL-INSUFFICIENCY; ASYMMETRIC
   DIMETHYLARGININE; INSULIN-RESISTANCE; CAPILLARY/MYOCYTE MISMATCH;
   MYOCARDIAL-INFARCTION; HYPERTENSIVE PATIENTS; SERUM CONCENTRATIONS;
   ACE-INHIBITION; BLOOD-PRESSURE
AB In recent years, increasing evidence has been provided that even minor renal dysfunction is a powerful cardiovascular risk factor that induces typical cardiovascular alterations and thus predisposes to coronary heart disease as well as to noncoronary cardiovascular problems. This first had been noted in patients with diabetes but now has been confirmed amply in patients without diabetes as well. Numerous heterogeneous abnormalities have been described in patients with early renal dysfunction (e.g., microalbuminuria, reduced estimated GFR). One final common pathway seems to be endothelial cell dysfunction. The link between albuminuria and generalized endothelial cell dysfunction (as indicated by diminished flow-mediated vasodilation, markers of endothelial cell dysfunction, sloughed off endothelial cells, and high transcapillary albumin escape rate) is unclear. In patients with early renal dysfunction, a long list of classical and nonclassical cardiovascular risk factors have been identified: Elevated asymmetric dimethyl-L-arginine concentrations, markers of microinflammation, oxidative stress, features of metabolic syndrome, abnormal adipokine concentrations, dyslipidemia, inappropriate activation of the renin-angiotensin system, and sympathetic overactivity. The mechanisms that link dysfunction of the kidney and the cardiovascular system are being sought. The most interesting unifying concept, however, is deranged fetal programming linking nephron underclosing to the increased cardiovascular risk.
C1 Univ Erlangen Nurnberg, Dept Pathol, Erlangen, Germany.
   Univ Wurzburg, Dept Internal Med, Wurzburg, Germany.
   Ruprecht Karls Univ Heidelberg, Dept Internal Med, Heidelberg, Germany.
C3 University of Erlangen Nuremberg; University of Wurzburg; Ruprecht Karls
   University Heidelberg
RP Ritz, E (corresponding author), Nierenzentrum, Dept Internal Med, Neuenheimer Feld 162, D-69120 Heidelberg, Germany.
EM prof.e.ritz@t-online.de
RI Wanner, Christoph/JOZ-1669-2023
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NR 107
TC 132
Z9 148
U1 0
U2 3
PU AMER SOC NEPHROLOGY
PI WASHINGTON
PA 1725 I ST, NW STE 510, WASHINGTON, DC 20006 USA
SN 1046-6673
EI 1533-3450
J9 J AM SOC NEPHROL
JI J. Am. Soc. Nephrol.
PD AUG
PY 2006
VL 17
IS 8
BP 2112
EP 2119
DI 10.1681/ASN.2006030204
PG 8
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 069LV
UT WOS:000239449000011
PM 16825329
OA Bronze
DA 2025-06-11
ER

PT J
AU Ahmad, N
   Lesa, KN
   Ikawati, Z
   Fakhrudin, N
AF Ahmad, Nazir
   Lesa, Kaisun Nesa
   Ikawati, Zullies
   Fakhrudin, Nanang
TI Health benefits of okra (Abelmoschus esculentus) against diabetes
   mellitus and cognitive dysfunction: a review
SO FOOD PRODUCTION PROCESSING AND NUTRITION
LA English
DT Review
DE Medicinal plants; Metabolic syndrome; Alzheimer's diseases; Insulin
   resistance; Phytochemical; Animal studies
ID ANTIOXIDANT PROPERTIES; INSULIN-RESISTANCE; OXIDATIVE STRESS; TYPE-2;
   MANAGEMENT; RISK; EPIDEMIOLOGY; FRACTIONS; EXTRACT
AB Diabetes mellitus (DM), both type 1 and type 2, has been linked to decreased performance across a number of cognitive function categories, with more recent studies emphasizing the contribution of DM mediated dementia. Despite the therapeutic advantages of antidiabetic medications for the management of DM mediated cognitive dysfunction (CD), the majority of these pharmaceuticals are linked to a number of negative side effects, raising questions about their long-term advantages. Botanical medicines, which often have low toxicity and adverse effects, are supported by some latter research. These medicines are attracting increased interest from researchers studying traditional herbal remedies owing to the minimal side effects for prevention and managing DM and CD in developing and developed countries. To emphasize the health benefits of okra (Abelmoschus esculentus) against DM and CD. Different databases, including PubMed, Google Scholar, and Scopus, were searched with a combination of keywords. The available research on the health benefits of okra against DM and CD is compiled in this study which indicates that okra has the ability to manage DM and CD. It will serve as a base for further investigation into the okra preparation for its potential commercial production as a therapeutic agent for DM and CD.
C1 [Ahmad, Nazir; Ikawati, Zullies] Univ Gadjah Mada, Fac Pharm, Dept Pharmacol & Clin Pharm, Sekip Utara 55281, Yogyakarta, Indonesia.
   [Ahmad, Nazir] Abasyn Univ, Dept Pharm, Islamabad Campus, Islamabad, Pakistan.
   [Lesa, Kaisun Nesa] Khulna Univ, Khulna City Corp Womens Coll, Dept Food & Nutr Sci, Khulna 9208, Bangladesh.
   [Lesa, Kaisun Nesa] Univ Gadjah Mada, Fac Agr Technol, Dept Food & Agr Prod Technol, Sekip Utara 55281, Yogyakarta, Indonesia.
   [Lesa, Kaisun Nesa] Nihon Univ Hosp, Dept Pediat, Tokyo 1028275, Japan.
   [Lesa, Kaisun Nesa] Jessore Univ Sci & Technol, Dept Nutr & Food Technol, Jessore 7400, Bangladesh.
   [Fakhrudin, Nanang] Univ Gadjah Mada, Fac Pharm, Dept Pharmaceut Biol, Sekip Utara 55281, Yogyakarta, Indonesia.
   [Fakhrudin, Nanang] Univ Gadjah Mada, Fac Pharm, Med Plants & Nat Prod Res Ctr, Sleman 55281, Yogyakarta, Indonesia.
C3 Gadjah Mada University; Khulna University; Gadjah Mada University; Nihon
   University; Gadjah Mada University; Gadjah Mada University
RP Fakhrudin, N (corresponding author), Univ Gadjah Mada, Fac Pharm, Dept Pharmaceut Biol, Sekip Utara 55281, Yogyakarta, Indonesia.; Fakhrudin, N (corresponding author), Univ Gadjah Mada, Fac Pharm, Med Plants & Nat Prod Res Ctr, Sleman 55281, Yogyakarta, Indonesia.
EM nanangf@ugm.ac.id
RI Ahmad, Nazir/GRS-1898-2022; LESA, KAISUN NESA/HKF-8553-2023; Fakhrudin,
   Nanang/AED-3803-2022; Ikawati, Zullies/GON-7755-2022
OI fakhrudin, nanang/0000-0001-7954-9503
FU Universitas Gadjah Mada for Gadjah Mada International Fellowship
   Scholarship
FX This work does not receive any funding sponsor. Nazir Ahmad and Kaisun
   Nesa Lesa thank Universitas Gadjah Mada for Gadjah Mada International
   Fellowship Scholarship for their postgraduate studies.
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NR 138
TC 0
Z9 0
U1 1
U2 1
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
EI 2661-8974
J9 FOOD PROD PROCESS NU
JI Food Prod. Process. Nutr.
PD FEB 14
PY 2025
VL 7
IS 1
AR 21
DI 10.1186/s43014-024-00284-y
PG 20
WC Food Science & Technology
WE Emerging Sources Citation Index (ESCI)
SC Food Science & Technology
GA W7I9I
UT WOS:001420276100001
OA gold
DA 2025-06-11
ER

PT J
AU Halvorson, BD
   Ward, AD
   Murrell, D
   Lacefield, JC
   Wiseman, RW
   Goldman, D
   Frisbee, JC
AF Halvorson, Brayden D.
   Ward, Aaron D.
   Murrell, Donna
   Lacefield, James C.
   Wiseman, Robert W.
   Goldman, Daniel
   Frisbee, Jefferson C.
TI Regulation of Skeletal Muscle Resistance Arteriolar Tone: Temporal
   Variability in Vascular Responses
SO JOURNAL OF VASCULAR RESEARCH
LA English
DT Article
DE Microcirculation; Regulation of vascular tone; Machine learning;
   Integration of arteriolar reactivity; Peripheral vasculature
ID HIGH-SALT DIET; BLOOD-PRESSURE; TISSUE OXYGENATION; METABOLIC SYNDROME;
   NITRIC-OXIDE; REACTIVITY; ADENOSINE; STRESS; FLOW; HEMODYNAMICS
AB Introduction: A full understanding of the integration of the mechanisms of vascular tone regulation requires an interrogation of the temporal behavior of arterioles across vasoactive challenges. Building on previous work, the purpose of the present study was to start to interrogate the temporal nature of arteriolar tone regulation with physiological stimuli. Methods: We determined the response rate of ex vivo proximal and in situ distal resistance arterioles when challenged by one-, two-, and three-parameter combinations of five major physiological stimuli (norepinephrine, intravascular pressure, oxygen, adenosine [metabolism], and intralumenal flow). Predictive machine learning models determined which factors were most influential in controlling the rate of arteriolar responses. Results: Results indicate that vascular response rate is dependent on the intensity of the stimulus used and can be severely hindered by altered environments, caused by application of secondary or tertiary stimuli. Advanced analytics suggest that adrenergic influences were dominant in predicting proximal arteriolar response rate compared to metabolic influences in distal arterioles. Conclusion: These data suggest that the vascular response rate to physiologic stimuli can be strongly influenced by the local environment. Translating how these effects impact vascular networks is imperative for understanding how the microcirculation appropriately perfuses tissue across conditions.
C1 [Halvorson, Brayden D.; Ward, Aaron D.; Murrell, Donna; Lacefield, James C.; Goldman, Daniel; Frisbee, Jefferson C.] Univ Western Ontario, Schulich Sch Med & Dent, Dept Med Biophys, London, ON, Canada.
   [Ward, Aaron D.; Murrell, Donna] Univ Western Ontario, Dept Oncol, London, ON, Canada.
   [Lacefield, James C.] Univ Western Ontario, Sch Biomed Engn, London, ON, Canada.
   [Wiseman, Robert W.] Michigan State Univ, Dept Physiol & Radiol, E Lansing, MI USA.
C3 Western University (University of Western Ontario); Western University
   (University of Western Ontario); Western University (University of
   Western Ontario); Michigan State University
RP Frisbee, JC (corresponding author), Univ Western Ontario, Schulich Sch Med & Dent, Dept Med Biophys, London, ON, Canada.
EM jfrisbee@uwo.ca
RI Goldman, Daniel/CAI-2887-2022; Halvorson, Brayden/IXN-1735-2023;
   Lacefield, James/B-5002-2015; Ward, Aaron/B-4950-2015
FU National Institutes of Health [R01 DK64668, RR 2865AR]; American Heart
   Association [0330194N, 0740129N, 13IRG14330015]; Canadian Institutes for
   Health Research [389769]; Natural Sciences and Engineering Research
   Council (Canada) [RGPIN-2018-05450, RGPIN-2019-06086]; American Heart
   Association (AHA) [0740129N, 0330194N, 13IRG14330015] Funding Source:
   American Heart Association (AHA)
FX The authors gratefully acknowledge the support provided from the
   National Institutes of Health (R01 DK64668, RR 2865AR), the American
   Heart Association (0330194N, 0740129N, 13IRG14330015), the Canadian
   Institutes for Health Research (#389769), and the Natural Sciences and
   Engineering Research Council (Canada; RGPIN-2018-05450,
   RGPIN-2019-06086).
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NR 52
TC 0
Z9 0
U1 0
U2 0
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1018-1172
EI 1423-0135
J9 J VASC RES
JI J. Vasc. Res.
PD DEC
PY 2024
VL 61
IS 6
BP 269
EP 297
DI 10.1159/000541169
EA OCT 2024
PG 29
WC Physiology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology; Cardiovascular System & Cardiology
GA Q0A1R
UT WOS:001329250000001
PM 39362208
DA 2025-06-11
ER

PT J
AU Alyahya, AM
AF Alyahya, Asma Mohammed
TI The role of progranulin in ischemic heart disease and its related risk
   factors
SO EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
LA English
DT Article
DE Progranulin; Adipokine; Ischemic heart disease; Myocardial ischemia-
   reperfusion
ID APOLIPOPROTEIN-A-I; MYOCARDIAL ISCHEMIA/REPERFUSION INJURY; INDUCED
   PLATELET-AGGREGATION; ENDOTHELIAL GROWTH-FACTOR; NECROSIS-FACTOR-ALPHA;
   CARDIOVASCULAR-DISEASE; NITRIC-OXIDE; INSULIN-RESISTANCE; OXIDATIVE
   STRESS; SUPEROXIDE GENERATION
AB Cardiovascular disease, in particular, ischemic heart disease, is the leading cause of mortality worldwide. Obesity and its related disorders are linked to cardiovascular events. Adipose tissue is an active endocrine organ that secretes bioactive molecules termed adipokines, which play an important role in heart function. Progranulin, one of the adipokines, plays a crucial role in health and disease. In relation to heart disease, progranulin has shown anti-inflammatory activity in the vascular endothelium and its deletion has exacerbated the atherosclerotic process. Progranulin binds to apo-lipoprotein A-1 and forms a complex attenuating pro-inflammatory activity of progranulin and stabilizing atherosclerotic plaques. The adipokine may have an athem-protective role by increasing nitric oxide level in the vascular endothelium by enhancing endothelial nitric oxide synthase phosphorylation, enhancing reverse cholesterol transport, and exerting an antithrombotic effect. Furthermore, PGRN exhibits protective properties in an acute ischemia-reperfusion injury. However, Progranulin has a proinflammatory action linked with cardiovascular risk factors, such as metabolic syndrome and type two diabetes. The review at hand sheds light on the interesting role that progranulin plays in ischemic heart disease and its related risk factors.
C1 [Alyahya, Asma Mohammed] King Saud Univ, Coll Med, Dept Physiol, POB 390174, Riyadh 11365, Saudi Arabia.
   [Alyahya, Asma Mohammed] King Saud Univ, Coll Med, Cardiovasc Res Grp, Riyadh, Saudi Arabia.
C3 King Saud University; King Saud University
RP Alyahya, AM (corresponding author), King Saud Univ, Coll Med, Dept Physiol, POB 390174, Riyadh 11365, Saudi Arabia.
EM asalyahya@ksu.edu.sa
FU King Abdul Aziz city for science and Technology [28235]
FX This study was kindly funded by King Abdul Aziz city for science and
   Technology (Grant No. 28235) .
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NR 162
TC 4
Z9 4
U1 1
U2 3
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0928-0987
EI 1879-0720
J9 EUR J PHARM SCI
JI Eur. J. Pharm. Sci.
PD AUG 1
PY 2022
VL 175
AR 106215
DI 10.1016/j.ejps.2022.106215
EA JUN 2022
PG 9
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 3J3ZL
UT WOS:000833336500005
PM 35609778
OA gold
DA 2025-06-11
ER

PT J
AU Fernandes, I
   Oliveira, J
   Pinho, A
   Carvalho, E
AF Fernandes, Iva
   Oliveira, Joana
   Pinho, Aryane
   Carvalho, Eugenia
TI The Role of Nutraceutical Containing Polyphenols in Diabetes Prevention
SO METABOLITES
LA English
DT Article
DE polyphenols; glucose; diabetes; insulin resistance; whole food;
   nutraceuticals
ID NON-EXTRACTABLE POLYPHENOLS; INSULIN-RESISTANCE; ANTIOXIDANT CAPACITY;
   METABOLIC SYNDROME; OXIDATIVE STRESS; INFLAMMATORY MARKERS;
   GLUCOSE-METABOLISM; MEDITERRANEAN DIET; COGNITIVE DECLINE; PLANT
   POLYPHENOLS
AB Research in pharmacological therapy has led to the availability of many antidiabetic agents. New recommendations for precision medicine and particularly precision nutrition may greatly contribute to the control and especially to the prevention of diabetes. This scenario greatly encourages the search for novel non-pharmaceutical molecules. In line with this, the daily and long-term consumption of diets rich in phenolic compounds, together with a healthy lifestyle, may have a protective role against the development of type 2 diabetes. In the framework of the described studies, there is clear evidence that the bio accessibility, bioavailability, and the gut microbiota are indeed affected by: the way phenolic compounds are consumed (acutely or chronically; as pure compounds, extracts, or in-side a whole meal) and the amount and the type of phenolic compounds (ex-tractable or non-extractable/macromolecular antioxidants, including non-bioavailable polyphenols and plant matrix complexed structures). In this review, we report possible effects of important, commonly consumed, phenolic-based nutraceuticals in pre-clinical and clinical diabetes studies. We highlight their mechanisms of action and their potential effects in health promotion. Translation of this nutraceutical-based approach still requires more and larger clinical trials for better elucidation of the mechanism of action toward clinical applications.
C1 [Fernandes, Iva; Oliveira, Joana] Univ Porto, Lab Associado Quim Verde REQUIMTE, Dept Quim & Bioquim, Fac Ciencias, Rua Campo Alegre 687, P-4169007 Porto, Portugal.
   [Pinho, Aryane; Carvalho, Eugenia] Univ Coimbra, Ctr Neurosci & Cell Biol, Fac Med, Rua Larga,Polo 1,1 Andar, P-3004504 Coimbra, Portugal.
   [Pinho, Aryane] Univ Coimbra, Dept Ciencias Vida, Fac Ciencias & Tecnol, P-3000456 Coimbra, Portugal.
   [Carvalho, Eugenia] Univ Coimbra, Inst Invest Interdisciplinar, Rua Dom Francisco de Lemos, P-3030789 Coimbra, Portugal.
   [Carvalho, Eugenia] APDP Portuguese Diabet Assoc, P-1250189 Lisbon, Portugal.
C3 Universidade do Porto; Universidade de Coimbra; Universidade de Coimbra;
   Universidade de Coimbra
RP Oliveira, J (corresponding author), Univ Porto, Lab Associado Quim Verde REQUIMTE, Dept Quim & Bioquim, Fac Ciencias, Rua Campo Alegre 687, P-4169007 Porto, Portugal.; Carvalho, E (corresponding author), Univ Coimbra, Ctr Neurosci & Cell Biol, Fac Med, Rua Larga,Polo 1,1 Andar, P-3004504 Coimbra, Portugal.; Carvalho, E (corresponding author), Univ Coimbra, Inst Invest Interdisciplinar, Rua Dom Francisco de Lemos, P-3030789 Coimbra, Portugal.; Carvalho, E (corresponding author), APDP Portuguese Diabet Assoc, P-1250189 Lisbon, Portugal.
EM iva.fernandes@fc.up.pt; jsoliveira@fc.up.pt; aryanepinho@cnc.uc.pt;
   ecarvalh@cnc.uc.pt
RI Oliveira, Joana/G-8108-2012; Carvalho, Eugenia/AAV-6868-2021; Fernandes,
   Iva/A-3050-2014; Oliveira, Joana/IXN-4356-2023
OI Carvalho, Eugenia/0000-0001-6264-3632; Fernandes,
   Iva/0000-0003-2297-0086; Cruz Oliveira Pinho,
   Aryane/0000-0003-2235-2237; Oliveira, Joana/0000-0002-9996-1463
FU European Regional Development Fund through the Centro 2020 Regional
   Operation Programme [HealthyAging2020-CENTRO-01-0145-FEDER-000012];
   COMPETE 2020-Operational Programme for Competitiveness and
   Internalization [POCI-01-0145-FEDER-007440, UIDB/04539/2020]; Associated
   Laboratory for Sustainable Chemistry, Clean Processes and Technologies
   LAQV [UIDB/50006/2020, UIDP/50006/2020]; AgriFood XXI I&D&I project
   (European Regional Development Fund (ERDF), through NORTE 2020 (Programa
   Operacional Regional do Norte 2014/2020) [NORTE-01-0145-FEDER-000041]
FX This work was financed by the European Regional Development Fund through
   the Centro 2020 Regional Operation Programme:
   HealthyAging2020-CENTRO-01-0145-FEDER-000012; by the COMPETE
   2020-Operational Programme for Competitiveness and Internalization;
   POCI-01-0145-FEDER-007440, UIDB/04539/2020. Financial supported was also
   obtained from the Associated Laboratory for Sustainable Chemistry, Clean
   Processes and Technologies LAQV through national funds from
   UIDB/50006/2020 and UIDP/50006/2020, and the AgriFood XXI I&D&I project
   (NORTE-01-0145-FEDER-000041, cofinanced by the European Regional
   Development Fund (ERDF), through NORTE 2020 (Programa Operacional
   Regional do Norte 2014/2020).
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NR 142
TC 24
Z9 24
U1 3
U2 20
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2218-1989
J9 METABOLITES
JI Metabolites
PD FEB
PY 2022
VL 12
IS 2
AR 184
DI 10.3390/metabo12020184
PG 28
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA ZK3GQ
UT WOS:000762880800001
PM 35208257
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Gomes, CD
   Passos, TS
   Morais, AHA
AF Gomes, Camila de Carvalho
   Passos, Thais Souza
   Araujo Morais, Ana Heloneida
TI Vitamin A Status Improvement in Obesity: Findings and Perspectives Using
   Encapsulation Techniques
SO NUTRIENTS
LA English
DT Review
DE retinoic acid; adipose tissue; provitamin A; carotenoids; solubility;
   functionality
ID SOLID LIPID NANOPARTICLES; BETA-CAROTENE; METABOLIC SYNDROME;
   DELIVERY-SYSTEMS; ORAL ABSORPTION; STABILITY; NANOENCAPSULATION;
   BIOAVAILABILITY; DEFICIENCY; STORAGE
AB The association between obesity and vitamin A has been studied. Some studies point to the anti-obesity activity related to this vitamin, carotenoids with provitamin A activity, and carotenoid conversion products. This performance has been evaluated in respect of adipogenesis, metabolic activity, oxidation processes, secretory function, and oxidative stress modulation, showing a new property attributed to vitamin A in preventing and treating obesity. However, vitamin A and its precursors are highly sensitive and easily degraded when subjected to heat, the presence of light, and oxygen, in addition to losses related to the processes of digestion and absorption. In this context, encapsulation presents itself as an alternative capable of increasing vitamin A's stability in the face of unfavorable conditions in the environment, which can reduce its functionality. Considering that vitamin A's status shows a strong correlation with obesity and is an innovative theme, this article addresses the associations between vitamin A's consumption and its precursors, encapsulated or not, and its physiological effects on obesity. The present narrative review points out those recent studies that demonstrate that vitamin A and its encapsulated precursors have the most preserved functionality, which guarantees better effects on obesity therapy.
C1 [Gomes, Camila de Carvalho; Araujo Morais, Ana Heloneida] Univ Fed Rio Grande do Norte, Ctr Biosci, Postgrad Program Biochem & Mol Biol, BR-59078970 Natal, RN, Brazil.
   [Passos, Thais Souza; Araujo Morais, Ana Heloneida] Univ Fed Rio Grande do Norte, Hlth Sci Ctr, Dept Nutr, BR-59078970 Natal, RN, Brazil.
   [Araujo Morais, Ana Heloneida] Univ Fed Rio Grande do Norte, Hlth Sci Ctr, Postgrad Program Nutr, BR-59078970 Natal, RN, Brazil.
C3 Universidade Federal do Rio Grande do Norte; Universidade Federal do Rio
   Grande do Norte; Universidade Federal do Rio Grande do Norte
RP Morais, AHA (corresponding author), Univ Fed Rio Grande do Norte, Ctr Biosci, Postgrad Program Biochem & Mol Biol, BR-59078970 Natal, RN, Brazil.; Morais, AHA (corresponding author), Univ Fed Rio Grande do Norte, Hlth Sci Ctr, Dept Nutr, BR-59078970 Natal, RN, Brazil.; Morais, AHA (corresponding author), Univ Fed Rio Grande do Norte, Hlth Sci Ctr, Postgrad Program Nutr, BR-59078970 Natal, RN, Brazil.
EM camila.carvalhog@hotmail.com; thais_spassos@yahoo.com.br;
   ana.morais@ufrn.br
RI Morais, Ana/KFB-9149-2024; Passos, Thais/LTZ-5160-2024
OI Passos, Thais/0000-0003-2054-1544; Morais, Ana/0000-0002-6460-911X
FU Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior [001-CAPES]
FX This work was supported for payment of fees by the Coordenacao de
   Aperfeicoamento de Pessoal de Nivel Superior (Finance Code 001-CAPES)
   research promotion agency.
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NR 64
TC 18
Z9 20
U1 0
U2 18
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JUN
PY 2021
VL 13
IS 6
AR 1921
DI 10.3390/nu13061921
PG 16
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA SZ0WP
UT WOS:000666297100001
PM 34204998
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Datta, S
   Snehlata
   Dutta, A
AF Datta, Sanchari
   Snehlata
   Dutta, Ajaswrata
TI Carbohydrate metabolism regulation: An insight into cellular response to
   ionizing radiation and cancer development
SO TRENDS IN CARBOHYDRATE RESEARCH
LA English
DT Article
DE Ionizing radiation; Cancer; Glucose metabolism; Metabolic disorders
ID IMPAIRED GLUCOSE-TOLERANCE; OXIDATIVE STRESS; SKELETAL-MUSCLE;
   INSULIN-RESISTANCE; AEROBIC GLYCOLYSIS; FRACTIONATED-IRRADIATION;
   PANCREATIC-CANCER; X-IRRADIATION; FREE-RADICALS; LIVING CELLS
AB Extracellular insults and intrinsic changes are associated with impaired metabolic functions, leading to the development of several disorders. Carbohydrate metabolism is one of the basic processes responsible for the supply of energy to cells, an imbalance of which can affect physiological and metabolic processes severely. In contrast to normal cells that use primarily mitochondrial oxidative phosphorylation for the source of energy, cancer cells alternatively rely on aerobic glycolysis for ATP generation. Cancer cells also show extensive metabolic reprogramming to support their growth and proliferation. This altered metabolic status is achieved by aberrant gene expressions, signaling, and redox status. Also, patients undergoing radiotherapy holds a great risk of developing metabolic disorders such as type 2 diabetes, hyperinsulinemia, and components of the metabolic syndrome. This article reviews the impact of ionizing radiation on cellular macromolecules with particular reference to carbohydrate metabolism. A comparison of glucose metabolism in normal and cancer cells is presented. Key molecular events that are relevant to alter metabolism in cancer cells are presented. We further focus on radiotherapy and chemotherapy influencing and targeting the metabolic status of cancer cells and finally, present different therapeutic interventions currently used to treat metabolic alterations.
C1 [Datta, Sanchari; Snehlata] Kalinga Inst Ind Technol KIIT, Sch Biotechnol, KIIT Rd, Bhubaneswar 751024, Odisha, India.
   [Dutta, Ajaswrata] Def Res & Dev Org DRDO, Div Radiat Biodosimetry, Inst Nucl Med & Allied Sci INMAS, Brig SK Mazumdar Marg, Delhi 110054, India.
C3 Kalinga Institute of Industrial Technology (KIIT); Defence Research &
   Development Organisation (DRDO); Institute of Nuclear Medicine & Allied
   Sciences (INMAS)
RP Dutta, A (corresponding author), Def Res & Dev Org DRDO, Div Radiat Biodosimetry, Inst Nucl Med & Allied Sci INMAS, Brig SK Mazumdar Marg, Delhi 110054, India.
EM ajaswratadutta@gmail.com
FU Defence Research Development Organisation, DRDO, India [INM-311/INM-313]
FX The cited research from the author's laboratory is supported by grants
   (INM-311/INM-313) from Defence Research Development Organisation, DRDO,
   India.
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NR 198
TC 0
Z9 0
U1 2
U2 2
PU NATURAL PRODUCTS & NON-WOOD FOREST PRODUCE UTILIZATION
PI DEHRA DUN
PA 5, PANDITWARI, PHASE-II, DEHRA DUN, 248007, INDIA
SN 0975-0304
J9 TRENDS CARBOHYDR RES
JI Trends Carbohydr. Res.
PY 2021
VL 13
IS 1
BP 42
EP 59
PG 18
WC Chemistry, Organic
WE Emerging Sources Citation Index (ESCI)
SC Chemistry
GA XQ9RQ
UT WOS:000731878500003
DA 2025-06-11
ER

PT J
AU Murashov, AK
   Pak, ES
   Lin, CT
   Boykov, IN
   Buddo, KA
   Mar, J
   Bhat, KM
   Neufer, PD
AF Murashov, Alexander K.
   Pak, Elena S.
   Lin, Chien-Te
   Boykov, Ilya N.
   Buddo, Katherine A.
   Mar, Jordan
   Bhat, Krishna M.
   Neufer, Peter Darrell
TI Preference and detrimental effects of high fat, sugar, and salt diet in
   wild-caught Drosophila simulans are reversed by flight exercise
SO FASEB BIOADVANCES
LA English
DT Article
DE Drosophila simulans; exercise; food preference; mitochondrial
   efficiency; obesity; western diet
ID INSULIN-RESISTANCE; STRESS RESISTANCE; FOOD PREFERENCES; LIFE-HISTORY;
   OBESITY; MELANOGASTER; MODEL; METABOLISM; TRANSPORT; MOUSE
AB High saturated fat, sugar, and salt contents are a staple of a Western diet (WD), contributing to obesity, metabolic syndrome, and a plethora of other health risks. However, the combinatorial effects of these ingredients have not been fully evaluated. Here, using the wild-caught Drosophila simulans, we show that a diet enriched with saturated fat, sugar, and salt is more detrimental than each ingredient separately, resulting in a significantly decreased lifespan, locomotor activity, sleep, reproductive function, and mitochondrial function. These detrimental effects were more pronounced in female than in male flies. Adding regular flight exercise to flies on the WD markedly negated the adverse effects of a WD. At the molecular level, the WD significantly increased levels of triglycerides and caused mitochondrial dysfunction, while exercise counterbalanced these effects. Interestingly, fruit flies developed a preference for the WD after pre-exposure, which was averted by flight exercise. The results demonstrate that regular aerobic exercise can mitigate adverse dietary effects on fly mitochondrial function, physiology, and feeding behavior. Our data establish Drosophila simulans as a novel model of diet-exercise interaction that bears a strong similarity to the pathophysiology of obesity and eating disorders in humans.
C1 [Murashov, Alexander K.; Pak, Elena S.; Lin, Chien-Te; Boykov, Ilya N.; Buddo, Katherine A.; Neufer, Peter Darrell] East Carolina Univ, Dept Physiol, Greenville, NC 27858 USA.
   [Murashov, Alexander K.; Pak, Elena S.; Lin, Chien-Te; Boykov, Ilya N.; Buddo, Katherine A.; Neufer, Peter Darrell] East Carolina Univ, East Carolina Diabet & Obes Inst, Greenville, NC 27858 USA.
   [Mar, Jordan; Bhat, Krishna M.] Univ S Florida, Dept Mol Med, Tampa, FL 33620 USA.
C3 University of North Carolina; East Carolina University; University of
   North Carolina; East Carolina University; State University System of
   Florida; University of South Florida
RP Murashov, AK (corresponding author), East Carolina Univ, 600 Moye Blvd,Brody Bldg 6N-98, Greenville, NC 27858 USA.
EM murashoval@ecu.edu
RI ; Murashov, Alexander/F-2241-2011
OI Boykov, Ilya/0000-0001-5112-6840; Murashov,
   Alexander/0000-0002-8912-5891; Mar, Jordan/0000-0003-4597-2404
FU NIH [R01 DK096907]; NIH-NIGMS;  [R15ES029673]; National Institute of
   General Medical Sciences [R01GM127478] Funding Source: NIH RePORTER
FX We would like to thank Thomas Werner (Michigan Technological University)
   for help with Drosophila simulans identification. We thank undergraduate
   students Damani Fitzgerald, Aaron Johnson, Imani Lowery, and Angela
   Sehres for technical assistance. This study was supported in parts by
   NIH R01 DK096907 (PDN), NIH-NIGMS (KMB), and R15ES029673 (AKM).
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NR 80
TC 16
Z9 17
U1 0
U2 15
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
EI 2573-9832
J9 FASEB BIOADV
JI FASEB Bioadv.
PD JAN
PY 2021
VL 3
IS 1
BP 49
EP 64
DI 10.1096/fba.2020-00079
PG 16
WC Biochemistry & Molecular Biology; Cell Biology
WE Emerging Sources Citation Index (ESCI)
SC Biochemistry & Molecular Biology; Cell Biology
GA YY1VS
UT WOS:000754582600007
PM 33490883
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Chaudhry, SR
   Akram, A
   Aslam, N
   Wajid, M
   Iqbal, Z
   Nazir, I
   Jabeen, Q
   Muhammad, S
AF Chaudhry, Shafqat Rasul
   Akram, Adnan
   Aslam, Naveed
   Wajid, Muhammad
   Iqbal, Zafar
   Nazir, Imran
   Jabeen, Qaiser
   Muhammad, Sajjad
TI Antidiabetic and antidyslipidemic potential of Echinops echinatus
   in rat models of type I and type II diabetes
SO PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES
LA English
DT Article
DE Antihyperglycemic; alloxan; antihyperlipidemic; insulin resistance;
   metabolic syndrome
ID INSULIN-RESISTANCE; OXIDATIVE STRESS; MEDICINAL-PLANTS; EXTRACT;
   ALLOXAN; PATHOPHYSIOLOGY; GLUCOSE
AB Echinops echinatus is traditionally an important plant that finds its extensive use as a diuretic, anti-inflammatory, anti-pyretic, nerve tonic, abortifacient, aphrodisiac, antiasthmatic, and antidiabetic agent. The current study investigates protection against the hyperglycemia and dyslipidemia in alloxan-induced (type I diabetes) and fructose-fed insulin resistance (type II diabetes) models of diabetes treated with aqueous methanolic root extract of E. echinatus (Ee.Cr). Albino rats were treated orally with Ee.Cr at doses 100, 300 and 500mg/kg. The fasting blood glucose was measured by glucometer, while standard kits were used to determine the levels of serum total cholesterol, triglycerides and HDL. The administration of Ee.Cr significantly (P<0.001) reduced the FBG concentration in a dose-dependent pattern in alloxan-induced and fructose-fed diabetic rats. The Ee.Cr also corrected the dyslipidemia associated with fructose and alloxan-induced diabetes by significantly (P<0.001) decreasing the concentration of serum total cholesterol, triglycerides, and LDL and by increasing HDL concentration. Ee.Cr also significantly (P<0.001) improved the glucose tolerance in fructose-fed rats. We conclude that Ee.Cr has antidiabetic and antidyslipidemic effects in both insulin-dependent alloxan-induced diabetes and fructose-induced insulin resistance diabetes rat models.
C1 [Chaudhry, Shafqat Rasul; Akram, Adnan; Aslam, Naveed; Wajid, Muhammad; Nazir, Imran; Jabeen, Qaiser] Islamia Univ Bahawalpur, Fac Pharm, Bahawalpur, Pakistan.
   [Chaudhry, Shafqat Rasul; Muhammad, Sajjad] Univ Bonn, Dept Neurosurg, Univ Hosp Bonn, Bonn, Germany.
   [Iqbal, Zafar] Univ Sains Malaysia, Sch Pharmaceut Sci, George Town, Malaysia.
C3 Islamia University of Bahawalpur; University of Bonn; Universiti Sains
   Malaysia
RP Chaudhry, SR (corresponding author), Islamia Univ Bahawalpur, Fac Pharm, Bahawalpur, Pakistan.; Chaudhry, SR (corresponding author), Univ Bonn, Dept Neurosurg, Univ Hosp Bonn, Bonn, Germany.
EM shafqatrasul@yahoo.com
RI Aslam, Naveed/AAD-5637-2020; iqbal, Zafar/F-6404-2015; Jabeen,
   Qaiser/IZE-0630-2023; Warsi, Muhammad/AAE-3020-2022; Chaudhry, Shafqat
   Rasul/AFM-0299-2022; Sajjad, Muhammad/AEB-9967-2022
OI Iqbal, Zafar/0000-0002-1334-6372; Aslam, Naveed/0000-0002-6305-3447;
   Muhammad, Sajjad/0000-0002-6734-7979; Jabeen, Qaiser/0000-0002-6346-860X
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NR 45
TC 3
Z9 3
U1 0
U2 2
PU UNIV KARACHI
PI KARACHI
PA UNIV CAMPUS, FAC PHARMACY, KARACHI, 75270, PAKISTAN
SN 1011-601X
J9 PAK J PHARM SCI
JI Pak. J. Pharm. Sci.
PD MAR
PY 2019
VL 32
IS 2
BP 505
EP 514
PG 10
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA HU1XL
UT WOS:000465065000005
PM 31081759
DA 2025-06-11
ER

PT J
AU Gamage, S
   Reddy, PH
   Dhurandhar, NV
   Hegde, V
AF Gamage, Suhadinie
   Reddy, P. Hemachandra
   Dhurandhar, Nikhil V.
   Hegde, Vijay
TI Potential role of E4orf1 protein in aging-associated impairment in
   glycemic control
SO JOURNAL OF DIABETES AND ITS COMPLICATIONS
LA English
DT Review
DE Aging; Glucose intolerance; Obesity; Type 2 diabetes; Ad36; E4orf1
ID INSULIN-RESISTANCE; METABOLIC SYNDROME; DIABETES-MELLITUS; OXIDATIVE
   STRESS; ADIPOSE-TISSUE; ADENOVIRUS 36; OBESITY; MUSCLE; ADULTS;
   PREVALENCE
AB Aging constitutes a major risk factor for the development of type-2 diabetes (T2D) where glucose tolerance declines with age, resulting in a high prevalence of T2D and impaired glucose tolerance in the elderly population. Currently more than half of the 20 million U.S. adults with T2D are above the age of 60, and the largest increase in T2D prevalence is expected in the elderly. Obesity is a causative factor for T2D associated insulin resistance and hyperglycemia. Furthermore, the aging process is accelerated by hyperglycemia and effective treatment options are limited for the vulnerable aging population. One of the mechanisms contributing to aging associated hyperglycemia is resistance to insulin-mediated glucose disposal. Chronic hyperglycemia also accelerates aging by increasing pro-inflammatory milieu leading to impaired immune function. Although currently available anti-diabetic agents improve glycemic control, they have potential serious side effects in some cases. Therefore, additional and better drugs are urgently needed for treatment of insulin resistance and aging associated health risk factors. This review presents the novel use of a microbial protein, E4orf1 as a potential anti-diabetic agent, which functions independent of insulin and obesity, highlighting the role of unique sources for future drug development. (C) 2018 Elsevier Inc. All rights reserved.
C1 [Gamage, Suhadinie; Dhurandhar, Nikhil V.; Hegde, Vijay] Texas Tech Univ, Nutr Sci Dept, Obes & Metab Hlth Lab, Lubbock, TX 79409 USA.
   [Reddy, P. Hemachandra] Texas Tech Univ, Garrison Inst Aging, Hlth Sci Ctr, Lubbock, TX 79430 USA.
C3 Texas Tech University System; Texas Tech University; Texas Tech
   University System; Texas Tech University Health Sciences Center Lubbock
RP Hegde, V (corresponding author), Texas Tech Univ, Dept Nutr Sci, 1301 Akron Ave,MS 1270, Lubbock, TX 79409 USA.
EM vijay.hegde@ttu.edu
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NR 55
TC 2
Z9 3
U1 0
U2 4
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1056-8727
EI 1873-460X
J9 J DIABETES COMPLICAT
JI J. Diabetes Complications
PD MAR
PY 2019
VL 33
IS 3
BP 261
EP 265
DI 10.1016/j.jdiacomp.2018.11.006
PG 5
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism
GA HM5NL
UT WOS:000459522300015
PM 30578020
DA 2025-06-11
ER

PT J
AU Wang, KJ
   Chen, SX
   Zhang, CJ
   Huang, JT
   Wu, J
   Zhou, HB
   Jin, LQ
   Qian, X
   Jin, JL
   Lyu, JX
AF Wang, Kejie
   Chen, Sixi
   Zhang, Congjie
   Huang, Jiatao
   Wu, Jia
   Zhou, Huaibin
   Jin, Liqin
   Qian, Xu
   Jin, Jinlong
   Lyu, Jianxin
TI Enhanced ROS production leads to excessive fat accumulation through
   DAF-16 in Caenorhabditis elegans
SO EXPERIMENTAL GERONTOLOGY
LA English
DT Article
DE Obesity; Caenorhabditis elegans; Reactive oxygen species; Fat
   accumulation; fat-5; daf-16
ID STEAROYL-COA DESATURASE; EXTENDS LIFE-SPAN; OXIDATIVE STRESS;
   MITOCHONDRIAL DYSFUNCTION; METABOLIC SYNDROME; OBESITY; MODEL;
   PREVALENCE; STRATEGIES; ADIPOSITY
AB Growing evidence shows that enhanced reactive oxygen species (ROS) production is an important contributor to obesity and its co-morbidities, but the functional link between ROS and obesity remains elusive. In this study we used the model animal Caenorhabditis elegans to explore the role of ROS in obesity. Initially, when ROS production was enhanced by treatment with low concentration of paraquat or juglone, both abnormal high fat accumulation and fatty acid composition were observed in wild type worms. We found that the abnormal fat accumulation was associated with increased expression of fat-5, which encodes an isoform of stearoyl-CoA synthetase, and which is regulated by daf-16 encoding the forkhead transcription factor and being activated by downregulation daf-2. When mutant daf-16 worms were used, the abnormal fat accumulation induced by ROS was suppressed. Collectively, we demonstrate that enhanced ROS production can lead to excessive fat accumulation and the change of fatty acid composition. This abnormal phenomenon at least in part depends on the daf-16 pathway by which fat-5 was regulated. The results point towards a role of ROS in obesity in the context of important conserved signaling pathway, thereby guide further studies and future therapeutic interventions.
C1 [Wang, Kejie; Chen, Sixi; Zhang, Congjie; Huang, Jiatao; Wu, Jia; Zhou, Huaibin; Jin, Liqin; Jin, Jinlong; Lyu, Jianxin] Wenzhou Med Univ, Minist Educ China, Key Lab Lab Med, Zhejiang Prov Key Lab Med Genet,Sch Lab Med & Lif, Wenzhou 325035, Zhejiang, Peoples R China.
   [Qian, Xu; Lyu, Jianxin] Hangzhou Med Coll, Dept Lab Med, Peoples Hosp, Hangzhou 310014, Zhejiang, Peoples R China.
C3 Ministry of Education - China; Wenzhou Medical University; Hangzhou
   Medical College
RP Lyu, JX (corresponding author), Wenzhou Med Univ, Minist Educ China, Key Lab Lab Med, Zhejiang Prov Key Lab Med Genet,Sch Lab Med & Lif, Wenzhou 325035, Zhejiang, Peoples R China.; Lyu, JX (corresponding author), Hangzhou Med Coll, Dept Lab Med, Peoples Hosp, Hangzhou 310014, Zhejiang, Peoples R China.
EM jxlu313@163.com
RI wu, jia/GXM-6959-2022
OI Wang, Ke-jie/0000-0001-5086-2299; Lyu, Jianxin/0000-0003-2343-1666
FU NIH National Center for Research Resources; Natural Science Foundation
   of Zhejiang Province [LY13H250002]; Research Project of Zhejiang
   Province Education Department [Y201534276]; Chinese Natural Science
   Foundation [81500440]
FX Caenorhabditis elegans strains were provided by the Caenorhabditis
   Genetics Center funded by the NIH National Center for Research
   Resources. This work was supported by the Natural Science Foundation of
   Zhejiang Province [grant number LY13H250002], Research Project of
   Zhejiang Province Education Department [grant number Y201534276], and
   the Chinese Natural Science Foundation [grant number 81500440].
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NR 48
TC 36
Z9 36
U1 12
U2 74
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0531-5565
EI 1873-6815
J9 EXP GERONTOL
JI Exp. Gerontol.
PD OCT 2
PY 2018
VL 112
BP 20
EP 29
DI 10.1016/j.exger.2018.07.017
PG 10
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA GV2HS
UT WOS:000445909300003
PM 30120932
DA 2025-06-11
ER

PT J
AU Muneer, A
   Mazommil, R
AF Muneer, Ather
   Mazommil, Rana
TI The Staging of Major Mood Disorders: Clinical and Neurobiological
   Correlates
SO PSYCHIATRY INVESTIGATION
LA English
DT Review
DE Bipolar disorder; Major depressive disorder; Staging; Allostatic load;
   Neuroprogression
ID EARLY NATURAL-HISTORY; BIPOLAR DISORDER; DEPRESSIVE DISORDER; OXIDATIVE
   STRESS; METABOLIC SYNDROME; TNF-ALPHA; HIGH-RISK; PATHWAYS;
   NEUROPROGRESSION; SCHIZOPHRENIA
AB Objective Staging of psychiatric disorders is gaining momentum and the purpose of this review is to examine whether major mood disorders can be defined according to stages.
   Methods In April 2018 the PubMed electronic data base was scrutinized by a combination of various search terms like "major depressive disorder and staging," "bipolar disorder and neuroprogression," etc. To incorporate the latest findings the search was limited to the last 10 years. Both original and review articles were examined by reading the abstracts, and papers which were found to be particularly applicable were read in full and their reference lists were also consulted.
   Results A significant increase occurred in the number of papers published on the topic of staging of mood disorders. Staging formats were found for both major mood disorders, with the caveat that many more articles were discovered for bipolar disorder. Current evidence points to allostatic load and neuroprogression as the basis for staging of mood disorders.
   Conclusion Principal affective illnesses may be characterized by distinct stages, for instance early, intermediate and late. These phases inform the management so that clinicians should incorporate the staging schema into everyday practice and implement treatment strategies according to the phase of the illness.
C1 [Muneer, Ather] Riphah Int Univ, Islamic Int Med Coll, 274 Peshawar Rd, Islamabad 2244, Pakistan.
   [Mazommil, Rana] Govt Khawaja Safdar Med Coll, Dept Psychiat, Sialkot, Pakistan.
RP Muneer, A (corresponding author), Riphah Int Univ, Islamic Int Med Coll, 274 Peshawar Rd, Islamabad 2244, Pakistan.
EM muneerather2@gmail.com
RI Muneer, Ather/H-8193-2019
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NR 70
TC 4
Z9 5
U1 0
U2 5
PU KOREAN NEUROPSYCHIATRIC ASSOC
PI SEOUL
PA RN 522, G-FIVE CENTRAL PLAZA 1685-8 SEOCHO 4-DONG, SEOCHO-GU, SEOUL,
   137-882, SOUTH KOREA
SN 1738-3684
EI 1976-3026
J9 PSYCHIAT INVEST
JI Psychiatry Investig.
PD AUG
PY 2018
VL 15
IS 8
BP 747
EP 758
DI 10.30773/pi.2018.05.26
PG 12
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA GR0NG
UT WOS:000442213800002
PM 30134644
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Qin, SY
   Wang, S
   Wang, X
   Wang, JB
AF Qin, Shaoyou
   Wang, Song
   Wang, Xu
   Wang, Jiangbin
TI Non-alcoholic fatty liver disease and the risk of urolithiasis A
   systematic review and meta-analysis
SO MEDICINE
LA English
DT Review
DE meta-analysis; nonalcoholic fatty liver disease; urolithiasis
ID CHRONIC KIDNEY-DISEASE; CARDIOVASCULAR-DISEASE; OXIDATIVE STRESS;
   METABOLIC SYNDROME; FREE-RADICALS; ASSOCIATION; STEATOHEPATITIS; NAFLD;
   PATHOGENESIS; PROGRESSION
AB There is growing evidence that nonalcoholic fatty liver disease (NAFLD) is associated with a higher risk of urolithiasis, but it has not yet been determined that this association is reproducible and consistent across different studies. We performed a systematic review and meta-analysis of these studies to examine the association between NAFLD and the risk of urolithiasis.
   We searched PubMed, EMBASE, and Google scholar using terms "fatty liver" (OR "non-alcoholic fatty liver disease" OR "nonalcoholic steatohepatitis" OR "NAFLD" OR "NASH") AND "urolithiasis" (OR "nephrolithiasis" OR "kidney stone" OR "urinary calculi" OR "renal colic" OR "urologic disease"). Observational studies in which NAFLD and urolithiasis were diagnosed by either ultrasonography or computerized tomography were included.
   A total of 7 observational studies with 226,541 individuals (24.7% with NAFLD) and 19,184 urolithiasis (8.5%). NAFLD was significantly associated with an increased risk of urolithiasis (random effect odds ratio, OR 1.73, 95% confidence interval, CI 1.24-2.40, I-2=94.5%). Sensitivity analyses revealed the robustness of the results. Egger test and Begg test suggested no publication bias (P>.05).
   NAFLD is associated with an increased risk of urolithiasis. Therefore, patients with NAFLD should be carefully monitored for the development of urolithiasis.
C1 [Qin, Shaoyou; Wang, Xu; Wang, Jiangbin] Jilin Univ, China Japan Union Hosp, Dept Gastroenterol & Hepatol, 126 Xiantai St, Changchun 130033, Jilin, Peoples R China.
   [Wang, Song] Jilin Univ, Hosp 1, Dept Urol, 71 Xinmin St, Changchun 130021, Jilin, Peoples R China.
C3 Jilin University; Jilin University
RP Wang, JB (corresponding author), Jilin Univ, China Japan Union Hosp, Dept Gastroenterol & Hepatol, 126 Xiantai St, Changchun 130033, Jilin, Peoples R China.; Wang, S (corresponding author), Jilin Univ, Hosp 1, Dept Urol, 71 Xinmin St, Changchun 130021, Jilin, Peoples R China.
EM wangsong_urologist@163.com; zrlwangjb@163.com
OI qin, shaoyou/0000-0003-4811-9767
FU Science and Technology Department of Jilin Province [20160414036GH,
   20170414031GH]; Education Department of Jilin Province [2015-517];
   Development and Reform Commission of Jilin Province [2015y031-2]; Wu
   Jieping Medical Foundation [320.6750.14028]
FX This study is funded by the Science and Technology Department of Jilin
   Province (Grant No. 20160414036GH, 20170414031GH), the Education
   Department of Jilin Province (Grant No. 2015-517), the Development and
   Reform Commission of Jilin Province (2015y031-2) and the Wu Jieping
   Medical Foundation (320.6750.14028).
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NR 43
TC 18
Z9 19
U1 0
U2 8
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD AUG
PY 2018
VL 97
IS 35
AR e12092
DI 10.1097/MD.0000000000012092
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA GW1AP
UT WOS:000446601900061
PM 30170429
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Omae, T
   Inada, E
AF Omae, Takeshi
   Inada, Eiichi
TI New-onset atrial fibrillation: an update
SO JOURNAL OF ANESTHESIA
LA English
DT Review
DE Anticoagulant therapy; Rhythm control; Rate control; Hemodynamic
   management; Perioperative atrial fibrillation
ID AORTIC-VALVE-REPLACEMENT; OPEN-HEART-SURGERY; HIGH-RISK PATIENTS;
   CHEST-PHYSICIANS GUIDELINES; CARDIAC-SURGERY; OFF-PUMP; POSTERIOR
   PERICARDIOTOMY; NONCARDIAC SURGERY; OXIDATIVE STRESS; BETA-BLOCKERS
AB New-onset atrial fibrillation (NOAF) is the most common perioperative complication of heart surgery, typically occurring in the perioperative period. NOAF commonly occurs in patients who are elderly, or have left atrial enlargement, or left ventricular hypertrophy. Various factors have been identified as being involved in the development of NOAF, and numerous approaches have been proposed for its prevention and treatment. Risk factors include diabetes, obesity, and metabolic syndrome. For prevention of NOAF, beta-blockers and amiodarone are particularly effective and are recommended by guidelines. NOAF can be treated by rhythm/rate control, and antithrombotic therapy. Treatment is required in patients with decreased cardiac function, a heart rate exceeding 130 beats/min, or persistent NOAF lasting for > 48 h. It is anticipated that anticoagulant therapies, as well as hemodynamic management, will also play a major role in the management of NOAF. When using warfarin as an anticoagulant, its dose should be adjusted based on PT-INR. PT-INR should be controlled between 2.0 and 3.0 in patients aged < 70 years and between 1.6 and 2.6 in those aged >70 years. Rate control combined with antithrombotic therapies for NOAF is expected to contribute to further advances in treatment and improvement of survival.
C1 [Omae, Takeshi] Juntendo Univ, Shizuoka Hosp, Dept Anesthesiol & Pain Clin, 1129 Nagaoka, Shizuoka 4102295, Japan.
   [Omae, Takeshi; Inada, Eiichi] Juntendo Univ, Sch Med, Dept Anesthesiol & Pain Med, Tokyo, Japan.
C3 Juntendo University; Juntendo University
RP Omae, T (corresponding author), Juntendo Univ, Shizuoka Hosp, Dept Anesthesiol & Pain Clin, 1129 Nagaoka, Shizuoka 4102295, Japan.; Omae, T (corresponding author), Juntendo Univ, Sch Med, Dept Anesthesiol & Pain Med, Tokyo, Japan.
EM omae@za2.so-net.ne.jp
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NR 109
TC 7
Z9 8
U1 0
U2 4
PU SPRINGER JAPAN KK
PI TOKYO
PA SHIROYAMA TRUST TOWER 5F, 4-3-1 TORANOMON, MINATO-KU, TOKYO, 105-6005,
   JAPAN
SN 0913-8668
EI 1438-8359
J9 J ANESTH
JI J. Anesth.
PD JUN
PY 2018
VL 32
IS 3
BP 414
EP 424
DI 10.1007/s00540-018-2478-8
PG 11
WC Anesthesiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Anesthesiology
GA GH6AB
UT WOS:000433519600015
PM 29523996
DA 2025-06-11
ER

PT J
AU Wruck, W
   Graffmann, N
   Kawala, MA
   Adjaye, J
AF Wruck, Wasco
   Graffmann, Nina
   Kawala, Marie-Ann
   Adjaye, James
TI Concise Review: Current Status and Future Directions on Research Related
   to Nonalcoholic Fatty Liver Disease
SO STEM CELLS
LA English
DT Review
DE Nonalcoholic fatty liver disease; Nonalcoholic steatohepatitis;
   Meta-analysis; Steatosis; microRNA; Induced pluripotent stem cells
ID HEPATIC STELLATE CELLS; ENDOPLASMIC-RETICULUM STRESS; IN-VITRO MODEL;
   VITAMIN-E; CONFERS SUSCEPTIBILITY; CHOLESTEROL-METABOLISM;
   CARDIOVASCULAR-DISEASE; THERAPEUTIC TARGETS; INSULIN-RESISTANCE;
   GENE-EXPRESSION
AB Considered a feature of the metabolic syndrome, nonalcoholic fatty liver disease (NAFLD), is associated with insulin resistance, type 2 diabetes, obesity and drug toxicity. Its prevalence is estimated at about 30% in western countries mainly due to sedentary life styles and high fat diets. Genome-wide association studies have identified polymorphisms in several genes, for example, PNPLA3, and TM6SF2 which confer susceptibility to NAFLD. Here, we review recent findings in the NAFLD field with a particular focus on published transcriptomics datasets which we subject to a meta-analysis. We reveal a common gene signature correlating with the progression of the disease from steatosis and steatohepatitis and reveal that lipogenic and cholesterol metabolic pathways are main actors in this signature. We propose the use of disease-in-a-dish models based on hepatocyte-like cells derived from patient-specific induced pluripotent stem cells (iPSC). These will enable investigations into the contribution of genetic background in the progression from NALFD to non-alcoholic steatohepatitis. Furthermore, an iPSC-based approach should aid in the elucidation of the function of new biomarkers, thus enabling better diagnostic tests and validation of potential drug targets.
C1 [Wruck, Wasco; Graffmann, Nina; Kawala, Marie-Ann; Adjaye, James] Heinrich Heine Univ, Fac Med, Inst Stem Cell Res & Regenerat Med, D-40225 Dusseldorf, Germany.
C3 Heinrich Heine University Dusseldorf
RP Adjaye, J (corresponding author), Heinrich Heine Univ, Fac Med, Inst Stem Cell Res & Regenerat Med, D-40225 Dusseldorf, Germany.
EM James.Adjaye@med.uni-duesseldorf.de
OI Graffmann, Nina/0000-0002-1229-0792
FU Medical Faculty of the Heinrich Heine University Dusseldorf, Germany
FX James Adjaye acknowledges support from the Medical Faculty of the
   Heinrich Heine University Dusseldorf, Germany.
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NR 75
TC 41
Z9 42
U1 1
U2 28
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1066-5099
EI 1549-4918
J9 STEM CELLS
JI Stem Cells
PD JAN
PY 2017
VL 35
IS 1
BP 89
EP 96
DI 10.1002/stem.2454
PG 8
WC Cell & Tissue Engineering; Biotechnology & Applied Microbiology;
   Oncology; Cell Biology; Hematology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Biotechnology & Applied Microbiology; Oncology; Hematology
GA EH7QD
UT WOS:000391966700012
PM 27374784
DA 2025-06-11
ER

PT J
AU Ni, YH
   Fen, ZG
   Nagashimada, M
   Ota, T
AF Ni, Yinhua
   Fen Zhuge
   Nagashimada, Mayumi
   Ota, Tsuguhito
TI Novel Action of Carotenoids on Non-Alcoholic Fatty Liver Disease:
   Macrophage Polarization and Liver Homeostasis
SO NUTRIENTS
LA English
DT Review
DE NAFLD/NASH; carotenoids; macrophages/Kupffer cells; insulin resistance;
   inflammation; fibrosis; antioxidant; beta-cryptoxanthin; astaxanthin
ID SERUM ALANINE AMINOTRANSFERASE; HEPATIC INSULIN-RESISTANCE; INDUCED
   OXIDATIVE STRESS; VITAMIN-E; BETA-CRYPTOXANTHIN; KUPFFER CELLS;
   ALTERNATIVE ACTIVATION; ASTAXANTHIN PREVENTS; CLINICAL-FEATURES; MOUSE
   MODEL
AB Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease. It is characterized by a wide spectrum of hepatic changes, which may progress to non-alcoholic steatohepatitis (NASH) and cirrhosis. NAFLD is considered a hepatic manifestation of metabolic syndrome; however, mechanisms underlying the onset and progression of NAFLD are still unclear. Resident and recruited macrophages are key players in the homeostatic function of the liver and in the progression of NAFLD to NASH. Progress has been made in understanding the molecular mechanisms underlying the polarized activation of macrophages. New NAFLD therapies will likely involve modification of macrophage polarization by restraining M1 activation or driving M2 activation. Carotenoids are potent antioxidants and anti-inflammatory micronutrients that have been used to prevent and treat NAFLD. In addition to their antioxidative action, carotenoids can regulate macrophage polarization and thereby halt the progression of NASH. In this review, we summarize the molecular mechanisms of macrophage polarization and the function of liver macrophages/Kupffer cells in NAFLD. From our review, we propose that dietary carotenoids, such as beta-cryptoxanthin and astaxanthin, be used to prevent or treat NAFLD through the regulation of macrophage polarization and liver homeostasis.
C1 [Ni, Yinhua; Fen Zhuge; Nagashimada, Mayumi; Ota, Tsuguhito] Kanazawa Univ, Brain Liver Interface Med Res Ctr, Dept Cell Metab & Nutr, Kanazawa, Ishikawa 9208640, Japan.
C3 Kanazawa University
RP Ota, T (corresponding author), Kanazawa Univ, Brain Liver Interface Med Res Ctr, Dept Cell Metab & Nutr, Kanazawa, Ishikawa 9208640, Japan.
EM shali0145@gmail.com; zgf0725@gmail.com; nakanaga@staff.kanazawa-u.ac.jp;
   tota@staff.kanazawa-u.ac.jp
RI Yinhua, Ni/H-3079-2015
OI Yinhua, Ni/0000-0001-7738-5971; Nagashimada, Mayumi/0000-0003-2714-6395
FU Ministry of Education, Culture, Sports, Science, and Technology of Japan
   [16K18700, 15H05345, 25282017, 16H03035, 15K12698]; Research Project on
   Development of Agricultural Products and Foods with Health-Promoting
   Benefits (NARO) from Ministry of Agriculture, Forestry and Fisheries
   (MAFF) [2013-A-10]; Grants-in-Aid for Scientific Research [16K18700,
   16H03035, 15K12698, 15H05345] Funding Source: KAKEN
FX This work was supported by the following grants: Grant-in-Aid for Young
   Scientists (B) (16K18700) (Y.N), Grant-in-Aid for Young Scientists (A)
   (15H05345) (M.N.), Grant-in-Aid for Scientific Research (B) (25282017,
   16H03035) (T.O.), and Challenging Exploratory Research (15K12698) (T.O.)
   from the Ministry of Education, Culture, Sports, Science, and Technology
   of Japan; and Research Project on Development of Agricultural Products
   and Foods with Health-Promoting Benefits (NARO) (2013-A-10) (T.O.) from
   the Ministry of Agriculture, Forestry and Fisheries (MAFF).
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Z9 78
U1 2
U2 32
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JUL
PY 2016
VL 8
IS 7
AR 391
DI 10.3390/nu8070391
PG 16
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA DS4QP
UT WOS:000380766200008
PM 27347998
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Murotomi, K
   Arai, S
   Uchida, S
   Endo, S
   Mitsuzumi, H
   Tabei, Y
   Yoshida, Y
   Nakajima, Y
AF Murotomi, Kazutoshi
   Arai, Shigeyuki
   Uchida, Satoko
   Endo, Shin
   Mitsuzumi, Hitoshi
   Tabei, Yosuke
   Yoshida, Yasukazu
   Nakajima, Yoshihiro
TI Involvement of splenic iron accumulation in the development of
   nonalcoholic steatohepatitis in Tsumura Suzuki Obese Diabetes mice
SO SCIENTIFIC REPORTS
LA English
DT Article
ID FATTY LIVER-DISEASE; OXIDATIVE STRESS; MOUSE MODEL; HESPERIDIN;
   FIBROSIS; SPLEEN; PATHOGENESIS; STEATOSIS; NASH; RATS
AB Nonalcoholic steatohepatitis (NASH) is a common hepatic manifestation of metabolic syndrome and can lead to hepatic cirrhosis and cancer. It is considered that NASH is caused by multiple parallel events, including abnormal lipid metabolism, gut-derived-endotoxin-induced inflammation, and adipocytokines derived from adipose tissue, suggesting that other tissues are involved in NASH development. Previous studies demonstrated that spleen enlargement is observed during the course of NASH pathogenesis. However, the involvement of splenic status in the progression of NASH remains unclear. In this study, we examined hepatic and splenic histopathological findings in the early stage of NASH using the Tsumura Suzuki Obese Diabetes (TSOD) mouse model established for assessing NASH. We found that 12-week-old TSOD mice clearly exhibited the histopathological features of NASH in the early stage. At this age, the spleen of TSOD mice showed markedly higher iron level than that of control Tsumura Suzuki Non Obesity (TSNO) mice. The level of accumulated iron was significantly decreased by feeding a diet with glucosyl hesperidin, a bioactive flavonoid, accompanied with alleviation of hepatic lesions. Furthermore, we found that splenic iron level was positively correlated with the severity of NASH manifestations, suggesting that abnormalities in the spleen are involved in the development of NASH.
C1 [Murotomi, Kazutoshi; Tabei, Yosuke; Yoshida, Yasukazu; Nakajima, Yoshihiro] Natl Inst Adv Ind Sci & Technol, Hlth Res Inst, Takamatsu, Kagawa 7610395, Japan.
   [Arai, Shigeyuki; Uchida, Satoko; Endo, Shin; Mitsuzumi, Hitoshi] Hayashibara Co Ltd, Naka Ku, Okayama 7028006, Japan.
C3 National Institute of Advanced Industrial Science & Technology (AIST)
RP Murotomi, K (corresponding author), Natl Inst Adv Ind Sci & Technol, Hlth Res Inst, Takamatsu, Kagawa 7610395, Japan.; Arai, S (corresponding author), Hayashibara Co Ltd, Naka Ku, Okayama 7028006, Japan.
EM k-murotomi@aist.go.jp; shigeyuki.arai@hb.nagase.co.jp
RI Tabei, Yosuke/L-8109-2018; Murotomi, Kazutoshi/J-1582-2018; Yoshida,
   Yasukazu/H-8510-2016; Nakajima, Yoshihiro/M-6935-2018
OI Yoshida, Yasukazu/0000-0001-6034-2502; Murotomi,
   Kazutoshi/0000-0002-2124-1538; Nakajima, Yoshihiro/0000-0002-7422-730X
CR Buechler C, 2011, WORLD J GASTROENTERO, V17, P2801, DOI 10.3748/wjg.v17.i23.2801
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NR 31
TC 18
Z9 19
U1 2
U2 21
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD MAR 2
PY 2016
VL 6
AR 22476
DI 10.1038/srep22476
PG 9
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA DF2KN
UT WOS:000371172000001
PM 26932748
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Zhang, Q
   Li, Y
   Liang, TT
   Lu, XM
   Liu, XK
   Zhang, C
   Jiang, X
   Martin, RC
   Cheng, ML
   Cai, L
AF Zhang, Quan
   Li, Yan
   Liang, Tingting
   Lu, Xuemian
   Liu, Xingkai
   Zhang, Chi
   Jiang, Xin
   Martin, Robert C.
   Cheng, Mingliang
   Cai, Lu
TI Loss of FGF21 in diabetic mouse during hepatocellular carcinogenetic
   transformation
SO AMERICAN JOURNAL OF CANCER RESEARCH
LA English
DT Article
DE Hepatocellular carcinoma; diabetes; OVE26 mice; dimethylnitrosamine;
   FGF21
ID GROWTH-FACTOR 21; FATTY LIVER-DISEASE; OXIDATIVE STRESS; NONALCOHOLIC
   STEATOHEPATITIS; EPIDEMIOLOGIC EVIDENCE; INSULIN-RESISTANCE; HEPATIC
   STEATOSIS; TRANSGENIC MICE; UNITED-STATES; CARCINOMA
AB Diabetes associated metabolic syndrome has been shown to be an independent risk factor for the development of hepatocellular carcinoma (HCC). Cirrhosis, in fact, was not always a prerequisite of HCC development and this might particularly apply to the metabolic abnormality associated HCC. This study was to investigate diabetes associated HCC and the potential role of FGF21 during carcinogenetic transformation of HCC. Dimethylnitrosamine (DEN) was used to induce HCC in the diabetic OVE26 mice. Pronounced damage characterized by steatohepatitis was found in the liver of diabetic mice. Steatohepatitis accompanied by constant cell proliferation and tumor cell growth were also found in the hepatic tissues of diabetic OVE26 mice when DEN being administrated. FGF21 protein level increased in liver tissues at an early stage along with steatohepatitis in diabetic OVE26 mice, but decreased in liver tissues later when HCC was developed. In addition, decreased FGF21 protein level was associated with cancerous hyper-proliferation and aberrant p53 and TGF-beta/Smad signaling during HCC development. Loss of FGF21 may play an important role in HCC carcinogenetic transformation during metabolic liver injury in diabetic animals. The present finding calls attention to the need to control metabolic disorders associated with diabetes and may further develop a protective strategy against HCC.
C1 [Zhang, Quan; Liang, Tingting; Cheng, Mingliang] Affiliated Hosp Guiyang, Coll Med, Dept Infect Dis, Guiyang 550004, Guizhou, Peoples R China.
   [Li, Yan; Martin, Robert C.] Univ Louisville, Sch Med, Dept Surg, Louisville, KY 40202 USA.
   [Zhang, Quan; Liang, Tingting; Lu, Xuemian; Zhang, Chi; Cai, Lu] Wenzhou Med Univ, Affiliated Hosp 3, Dept Endocrinol, Chinese Amer Res Inst Diabet Complicat,Ruian Ctr, Ruian 325200, Zhejiang, Peoples R China.
   [Liu, Xingkai; Jiang, Xin] Jilin Univ, Hosp 1, Changchun 130021, Peoples R China.
   [Cai, Lu] Univ Louisville, Dept Pediat, Kosair Childrens Hosp Res Inst, Louisville, KY 40202 USA.
C3 University of Louisville; Wenzhou Medical University; Jilin University;
   University of Louisville
RP Li, Y (corresponding author), Univ Louisville, Sch Med, Div Surg Oncol, Dept Surg, 511 S Floyd ST MDR Bldg Rm326A, Louisville, KY 40202 USA.
EM Yan.li@louisville.edu; cheng.ml@21.cn.com
RI liang, ting/JFB-4960-2023; Wang, Yahui/JCO-6233-2023; Martin,
   Roberto/O-6158-2014; Cai, Lu/AAG-9920-2019; Jiang, Xin/AHA-9454-2022
OI Jiang, Xin/0000-0002-4613-7438
FU American Diabetes Association Basic Science Award [1-13-BS-109]; Natural
   Science Foundation of Guizhou Educational Department [2011037]
FX This work was supported in part by American Diabetes Association Basic
   Science Award (1-13-BS-109) and Natural Science Foundation of Guizhou
   Educational Department (No. 2011037).
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NR 55
TC 26
Z9 28
U1 0
U2 5
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 2156-6976
J9 AM J CANCER RES
JI Am. J. Cancer Res.
PY 2015
VL 5
IS 5
BP 1762
EP 1774
PG 13
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA CN3YJ
UT WOS:000358364200016
PM 26175944
DA 2025-06-11
ER

PT J
AU Neuparth, MJ
   Proença, JB
   Santos-Silva, A
   Coimbra, S
AF Neuparth, Maria Joao
   Proenca, Jorge Brandao
   Santos-Silva, Alice
   Coimbra, Susana
TI The Positive Effect of Moderate Walking Exercise on Chemerin Levels in
   Portuguese Patients With Type 2 Diabetes Mellitus
SO JOURNAL OF INVESTIGATIVE MEDICINE
LA English
DT Article
DE physical exercise; adipokines; body mass index; inflammation; lipid
   peroxidation
ID METABOLIC SYNDROME; OBESITY; ADIPONECTIN; INFLAMMATION; LEPTIN;
   CYTOKINES; ADIPOKINE; PROTEIN
AB Background: Physical exercise intervention is known to be crucial in the management of type 2 diabetes mellitus (T2DM). We aimed to evaluate, in patients with T2DM, the effect of regular moderate walking exercise on markers of oxidative stress, lipid metabolism, and inflammation.
   Methods: We studied 30 patients with T2DM who walked regularly during the last year and 53 patients with T2DM who did not perform any type of exercise. The patients were evaluated for chemerin, adiponectin, leptin, oxidized low-density lipoprotein, and C-reactive protein (CRP) levels.
   Results: The active T2DM patients showed significantly lower body mass index, as compared with the inactive patients. The active T2DM patients showed significantly lower levels of chemerin and CRP than those of the inactive T2DM patients (CRP lost significance after adjustment for body mass index). The active patients, compared with the inactive, presented a trend toward higher levels of adiponectin and lower values of oxidized low-density lipoprotein. Leptin differed significantly between sexes, and the active women presented a trend toward lower levels as compared with the inactive women.
   Conclusions: In the patients with T2DM, the practice of moderate walking in a regular basis was sufficient to reduce chemerin levels, which suggests that practice of regular physical exercise should be encouraged.
C1 [Neuparth, Maria Joao] Univ Porto, Ctr Invest Actvidade Fis Saude & Lazer CIAFEL, P-4100 Oporto, Portugal.
   [Neuparth, Maria Joao; Proenca, Jorge Brandao; Coimbra, Susana] CESPU, Inst Invest & Formacao Avancada Ciencias & Tecnol, P-4585116 Gandra Prd, Portugal.
   [Santos-Silva, Alice] Fac Farm FFUP, Dept Ciencias Biol, Lab Bioquim, Oporto, Portugal.
   [Santos-Silva, Alice; Coimbra, Susana] Univ Porto, IBMC, P-4100 Oporto, Portugal.
C3 Universidade do Porto; Universidade do Porto
RP Neuparth, MJ (corresponding author), CESPU, Inst Invest & Formacao Avancada Ciencias & Tecnol, Rua Cent Gandra 1317, P-4585116 Gandra Prd, Portugal.
EM mneuparth@hotmail.com; ssn.coimbra@gmail.com
RI Santos-Silva, Alice/AAC-7082-2020; Santos-Silva, Alice/K-2326-2013;
   Coimbra, Susana/K-4466-2013; Neuparth, Maria Joao/L-8805-2013
OI Santos-Silva, Alice/0000-0002-2565-3169; Coimbra,
   Susana/0000-0001-8411-8038; Proenca, Jorge/0000-0002-6295-4710;
   Neuparth, Maria Joao/0000-0002-1464-8700
FU Centro de Investigacao das Tecnologias da Saude - CITS
   [06-2011-CITS/CESPU]
FX Supported by Centro de Investigacao das Tecnologias da Saude - CITS
   (06-2011-CITS/CESPU).
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NR 20
TC 22
Z9 25
U1 0
U2 9
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1081-5589
EI 1708-8267
J9 J INVEST MED
JI J. Invest. Med.
PD FEB
PY 2014
VL 62
IS 2
BP 350
EP 353
DI 10.2310/JIM.0000000000000025
PG 4
WC Medicine, General & Internal; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Research & Experimental Medicine
GA AL3SH
UT WOS:000339048800008
PM 24217118
DA 2025-06-11
ER

PT J
AU de Oliveira, MC
   Torrezan, R
   da Costa, CEM
   Ambiel, CR
   Constantin, RP
   Ishii-Iwamoto, EL
   Salgueiro-Pagadigorria, CL
AF de Oliveira, Monique Cristine
   Torrezan, Rosana
   Mareze da Costa, Cecilia Edna
   Ambiel, Celia Regina
   Constantin, Rodrigo Polimeni
   Ishii-Iwamoto, Emy Luiza
   Salgueiro-Pagadigorria, Clairce Luzia
TI Changes in calcium fluxes in mitochondria, microsomes, and plasma
   membrane vesicles of livers from monosodium L-glutamate-obese rats
SO METABOLISM-CLINICAL AND EXPERIMENTAL
LA English
DT Article
ID NONALCOHOLIC FATTY LIVER; INSULIN-RESISTANCE; SEQUESTRATION ACTIVITY;
   METABOLIC SYNDROME; ATPASE ACTIVITIES; OXIDATIVE STRESS; ARTHRITIC RATS;
   STEATOHEPATITIS; GLYCOGENOLYSIS; METHOTREXATE
AB The purpose of this work was to evaluate if the fat liver accumulation interferes with intracellular calcium fluxes and the liver glycogenolytic response to a calcium-mobilizing alpha(1)-adrenergic agonist, phenylephrine. The animal model of monosodium L-glutamate (MSG)-induced obesity was used. The adult rats develop obesity and steatosis. Calcium fluxes were evaluated through measuring the (45)Ca(2+) uptake by liver microsomes, inside-out plasma membrane, and mitochondria. In the liver, assessments were performed on the calcium-dependent glycogenolytic response to phenylephrine and the glycogen contents. The Ca(2+) uptake by microsomes and plasma membrane vesicles was reduced in livers from Obese rats as a result of reduction in the Ca(2+)-ATPase activities. In addition, the plasma membrane Na(+)/K(+)-ATPase was reduced. All these matched effects could contribute to elevated resting intracellular calcium levels in the hepatocytes. Livers from obese rats, albeit smaller and with similar glycogen contents to those of control rats, released higher amounts of glucose in response to phenylephrine infusion, which corroborates these observations. Mitochondria from obese rats exhibited a higher capacity of retaining calcium, a phenomenon that could be attributed to a minor susceptibility of the mitochondrial permeability transition pore opening. (C) 2011 Elsevier Inc. All rights reserved.
C1 [Torrezan, Rosana; Mareze da Costa, Cecilia Edna; Ambiel, Celia Regina; Salgueiro-Pagadigorria, Clairce Luzia] Univ Maringa, Dept Physiol Sci, BR-87020900 Maringa, Parana, Brazil.
   [de Oliveira, Monique Cristine; Ishii-Iwamoto, Emy Luiza] Univ Maringa, Dept Biochem, Lab Biol Oxidat, BR-87020900 Maringa, Parana, Brazil.
   [Constantin, Rodrigo Polimeni] Univ Maringa, Dept Biochem, Lab Liver Metab, BR-87020900 Maringa, Parana, Brazil.
RP Salgueiro-Pagadigorria, CL (corresponding author), Univ Maringa, Dept Physiol Sci, BR-87020900 Maringa, Parana, Brazil.
EM clspagadigorria@uem.br
RI Ishii-Iwamoto, Emy/C-1323-2013; Constantin, Rodrigo/A-4727-2016;
   Oliveira, Monique/M-2241-2016
OI Oliveira, Monique/0000-0002-9667-0724; Ishii Iwamoto, Emy
   Luiza/0000-0001-8708-3643
FU Conselho Nacional de Pesquisa Cientifica e Tecnologica (CNPq); Programa
   de Nucleos de Excelencia do Ministerio de Ciencia e Tecnologia (PRONEX);
   Fundacao Araucaria
FX This work was supported by grants from Fundacao Araucaria, Conselho
   Nacional de Pesquisa Cientifica e Tecnologica (CNPq), and Programa de
   Nucleos de Excelencia do Ministerio de Ciencia e Tecnologia (PRONEX).
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NR 60
TC 3
Z9 3
U1 0
U2 3
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0026-0495
J9 METABOLISM
JI Metab.-Clin. Exp.
PD OCT
PY 2011
VL 60
IS 10
BP 1433
EP 1441
DI 10.1016/j.metabol.2011.02.011
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 826IN
UT WOS:000295347900012
PM 21489575
DA 2025-06-11
ER

PT J
AU Sammito, S
   Thielmann, B
   Klussmann, A
   Deussen, A
   Braumann, KM
   Boeckelmann, I
AF Sammito, Stefan
   Thielmann, Beatrice
   Klussmann, Andre
   Deussen, Andreas
   Braumann, Klaus-Michael
   Boeckelmann, Irina
TI Guideline for the application of heart rate and heart rate variability
   in occupational medicine and occupational health science
SO JOURNAL OF OCCUPATIONAL MEDICINE AND TOXICOLOGY
LA English
DT Review
DE Autonomous nervous system; Sympathetic nervous system; Parasympathetic
   nervous system; Stress; Strain
ID AUTONOMIC NERVOUS-SYSTEM; METABOLIC-SYNDROME; CARDIOVASCULAR-DISEASE;
   SPECTRAL-ANALYSIS; SHORT-TERM; PHYSICAL-ACTIVITY; AIR-POLLUTION;
   SEX-DIFFERENCES; BLOOD-PRESSURE; RISK-FACTORS
AB This updated guideline replaces the "Guideline for the application of heart rate and heart rate variability in occupational medicine and occupational health science" first published in 2014. Based on the older version of the guideline, the authors have reviewed and evaluated the findings on the use of heart rate (HR) and heart rate variability (HRV) that have been published in the meantime and incorporated them into a new version of this guideline.This guideline was developed for application in clinical practice and research purposes in the fields of occupational medicine and occupational science to complement evaluation procedures with respect to exposure and risk assessment at the workplace by the use of objective physiological workload indicators. In addition, HRV is also suitable for assessing the state of health and for monitoring the progress of illnesses and preventive medical measures. It gives an overview of factors influencing the regulation of the HR and HRV at rest and during work. It further illustrates methods for measuring and analyzing these parameters under standardized laboratory and real workload conditions, areas of application as well as the quality control procedures to be followed during the recording and evaluation of HR and HRV.
C1 [Sammito, Stefan; Thielmann, Beatrice; Boeckelmann, Irina] Otto von Guericke Univ, Med Fac, Dept Occupat Med, Magdeburg, Germany.
   [Sammito, Stefan] German Ctr Aerosp Med, Expt Aerosp Med Res, Flughafenstr 1, D-51147 Cologne, Germany.
   [Klussmann, Andre] Univ Appl Sci HAW Hamburg, Competence Ctr Hlth CCG, Dept Hlth Sci, Hamburg, Germany.
   [Deussen, Andreas] Med Fac, Dept Physiol, TU Dresden, Dresden, Germany.
   [Braumann, Klaus-Michael] Univ Hamburg, Dept Sport Med, Hamburg, Germany.
C3 Otto von Guericke University; Technische Universitat Dresden; University
   of Hamburg
RP Sammito, S (corresponding author), Otto von Guericke Univ, Med Fac, Dept Occupat Med, Magdeburg, Germany.; Sammito, S (corresponding author), German Ctr Aerosp Med, Expt Aerosp Med Res, Flughafenstr 1, D-51147 Cologne, Germany.
EM StefanSammito@bundeswehr.org
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NR 270
TC 11
Z9 11
U1 7
U2 11
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1745-6673
J9 J OCCUP MED TOXICOL
JI J. Occup. Med. Toxicol.
PD MAY 13
PY 2024
VL 19
IS 1
AR 15
DI 10.1186/s12995-024-00414-9
PG 29
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA QM7I3
UT WOS:001221351400001
PM 38741189
OA Green Published, gold
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Zhu, T
   Zhao, HX
   Chao, YF
   Gao, SY
   Dong, X
   Wang, ZW
AF Zhu, Tong
   Zhao, Hongxia
   Chao, Yufan
   Gao, Songyan
   Dong, Xin
   Wang, Zuowei
TI Olanzapine-induced weight gain and lipid dysfunction in mice between
   different gender
SO BIOMEDICAL CHROMATOGRAPHY
LA English
DT Article
DE dyslipidemia; lipidomics; olanzapine; schizophrenia
ID METABOLIC SYNDROME; ATYPICAL ANTIPSYCHOTICS; OXIDATIVE STRESS;
   SCHIZOPHRENIA; OBESITY; PHYSIOLOGY; DRUGS; PHARMACOKINETICS;
   BIOCHEMISTRY; DISORDERS
AB As one of the most common antipsychotics, olanzapine may cause metabolic-related adverse effects, but it is still unknown how olanzapine alters lipid metabolism. In this study, we found that olanzapine-treated mice showed varying degrees of dyslipidemia, which was particularly pronounced in female mice. Based on ultra-performance liquid chromatography-quadrupole time-of-flight-MS (UPLC-Q-TOF-MS) technology and lipid metabolomics, we mapped the changes in lipid metabolism in olanzapine-treated mice and then compared the changes in lipid metabolism between male and female mice. There were 98 metabolic differentiators between the olanzapine-treated and control groups in females and 79 in males. These metabolites were glycerolipids, glycerophospholipids, fatty amides, and sphingolipids, which are involved in glycerolipid metabolism, glycerophospholipid metabolism, and fatty acid metabolism. These results suggest that olanzapine-induced changes in the levels of lipid metabolites are closely associated with disturbances in lipid metabolic pathways, which may underlie lipemia. This lipidome profiling study not only visualizes changes in lipid metabolism in liver tissue but also provides a foundation for understanding the regulatory pathways and mechanisms involved in olanzapine-induced lipid metabolism disorders. Furthermore, this study demonstrates differences in lipid metabolism between males and females, providing a reference for clinical treatment regimen selection.
C1 [Zhu, Tong; Chao, Yufan; Dong, Xin; Wang, Zuowei] Shanghai Univ, Sch Med, Shanghai, Peoples R China.
   [Zhu, Tong] Shanghai Univ, Sch Life Sci, Shanghai, Peoples R China.
   [Zhao, Hongxia] Cent Peoples Hosp Zhanjiang, Zhanjiang Inst Clin Med, Zhanjiang, Peoples R China.
   [Gao, Songyan] Shanghai Univ, Inst Translat Med, Shanghai, Peoples R China.
   [Wang, Zuowei] Shanghai Hongkou Mental Hlth Ctr, Div Mood Disorders, Shanghai, Peoples R China.
   [Wang, Zuowei] Shanghai Univ, Clin Res Ctr Mental Hlth, Sch Med, Shanghai, Peoples R China.
   [Dong, Xin; Wang, Zuowei] Shanghai Univ, Sch Med, 99 Shangda Rd, Shanghai 200444, Peoples R China.
C3 Shanghai University; Shanghai University; Shanghai University; Shanghai
   University; Shanghai University
RP Dong, X; Wang, ZW (corresponding author), Shanghai Univ, Sch Med, 99 Shangda Rd, Shanghai 200444, Peoples R China.
EM dongxinsmmu@126.com; wzwhk@163.com
RI Wang, Zuowei/AAT-8116-2020; zhao, hongxia/K-1085-2015
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NR 57
TC 0
Z9 0
U1 4
U2 10
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0269-3879
EI 1099-0801
J9 BIOMED CHROMATOGR
JI Biomed. Chromatogr.
PD JUN
PY 2024
VL 38
IS 6
DI 10.1002/bmc.5864
EA MAR 2024
PG 19
WC Biochemical Research Methods; Biochemistry & Molecular Biology;
   Chemistry, Analytical; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry; Pharmacology & Pharmacy
GA RH0Z1
UT WOS:001193189800001
PM 38551083
DA 2025-06-11
ER

PT J
AU Singh, S
   Sharma, S
   Sharma, H
AF Singh, Sonia
   Sharma, Shiwangi
   Sharma, Himanshu
TI Potential Impact of Bioactive Compounds as NLRP3 Inflammasome
   Inhibitors: An Update
SO CURRENT PHARMACEUTICAL BIOTECHNOLOGY
LA English
DT Review
DE Inflammasome; NLRP3; apoptosis; bioactive compounds; cytokines; LDL
ID NF-KAPPA-B; LEUCINE-RICH REPEAT; NALP3 INFLAMMASOME; K+ EFFLUX;
   CARDIOVASCULAR-DISEASE; RHEUMATOID-ARTHRITIS; ATRIAL-FIBRILLATION;
   SIGNALING PATHWAYS; OXIDATIVE STRESS; ASTRAGALOSIDE IV
AB The inflammasome NLRP3 comprises a caspase recruitment domain, a pyrin domain containing receptor 3, an apoptosis-linked protein like a speck containing a procaspase-1, and an attached nucleotide domain leucine abundant repeat. There are a wide variety of stimuli that can activate the inflammasome NLRP3. When activated, the protein NLRP3 appoints the adapter protein ASC. Adapter ASC protein then recruits the procaspase-1 protein, which causes the procaspase-1 protein to be cleaved and activated, which induces cytokines. At the same time, abnormal activation of inflammasome NLRP3 is associated with many diseases, such as diabetes, atherosclerosis, metabolic syndrome, cardiovascular and neurodegenerative diseases. As a result, a significant amount of effort has been put into comprehending the mechanisms behind its activation and looking for their specific inhibitors. In this review, we primarily focused on phytochemicals that inhibit the inflammasome NLRP3, as well as discuss the defects caused by NLRP3 signaling. We conducted an in-depth research review by searching for relevant articles in the Scopus, Google Scholar, and PubMed databases. By gathering information on phytochemical inhibitors that block NLRP3 inflammasome activation, a complicated balance between inflammasome activation or inhibition with NLRP3 as a key role was revealed in NLRP3-driven clinical situations.
C1 [Singh, Sonia; Sharma, Shiwangi] GLA Univ, Inst Pharmaceut Res, Dept Pharm, Mathura 281406, Uttar Pradesh, India.
   [Sharma, Himanshu] GLA Univ, Dept Comp Engn & Applicat, Chaumuhan 281406, Uttar Pradesh, India.
C3 GLA University; GLA University
RP Singh, S (corresponding author), GLA Univ, Inst Pharmaceut Res, Dept Pharm, Mathura 281406, Uttar Pradesh, India.
EM sonia.singh@gla.ac.in
RI Singh, Sonia/AAR-6504-2021
FX Declared none.
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NR 202
TC 0
Z9 0
U1 2
U2 5
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1389-2010
EI 1873-4316
J9 CURR PHARM BIOTECHNO
JI Curr. Pharm. Biotechnol.
PY 2024
VL 25
IS 13
BP 1719
EP 1746
DI 10.2174/0113892010276859231125165251
PG 28
WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
GA A6B1M
UT WOS:001283357400003
PM 38173061
DA 2025-06-11
ER

PT J
AU Ding, Q
   Wen, K
   Li, Q
   Zhao, QH
   Zhao, JL
   Xiao, YF
   Guan, XH
   Jiang, MX
   Zhang, F
   Wang, LF
AF Ding, Qi
   Wen, Ke
   Li, Qian
   Zhao, Qi-Hang
   Zhao, Jia-Le
   Xiao, Yun-Fei
   Guan, Xiao-Hui
   Jiang, Mei-Xiu
   Zhang, Feng
   Wang, Ling -Fang
TI CD38 deficiency promotes skeletal muscle and brown adipose tissue energy
   expenditure through activating NAD+-Sirt1-PGC1α signaling pathway
SO CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
LA English
DT Article; Early Access
DE CD38; Sirt1; energy expenditure; PGC1 alpha
ID MITOCHONDRIAL; METABOLISM; OBESITY
AB Obesity is a metabolic syndrome characterized by abnormal lipid deposition and energy imbalance. CD38 is a single-chain transmembrane glycoprotein widely expressed in a variety of cell types. The roles of skeletal muscle and brown fat in CD38 deficiency under HFD-induced obesity remain unknown. In this study, we established obesity model with HFD and examined the changes in metabolites with metabonomics. Our results showed that CD38 expression was increased in muscle and brown fat after HFD treatment. Moreover, the results of metabonomics showed that CD38 deficiency significantly altered the metabolites in energy metabolism, cofactor generation, and redox homeostasis. Furthermore, CD38 deficiency reduced the expressions of NADPH oxidase 2 and FASN in mRNA level. We found that the expressions of Sirt1, Sirt3, and PGC1a were upregulated in CD38-deficient muscle tissue. In brown fat, the Sirt1-3, cell death inducing DFFA-like effector A, ELOVL3, and Dio2 expressions were increased in CD38-deficient mice. Our results showed the uncoupling protein 1 expression was upregulated. And NAD+ supplementation increased the expression of Sirt1 and PGC1a after palmitic acid treatment. Taken together, our results demonstrated that the protection of CD38 deficiency on HFD-induced obesity was related to the inhibition of oxidative stress and increasing energy expenditure via activating NAD+/Sirtuins signaling pathways in muscle and brown fat.
C1 [Ding, Qi; Wen, Ke; Li, Qian; Zhao, Qi-Hang; Zhao, Jia-Le; Xiao, Yun-Fei; Guan, Xiao-Hui; Jiang, Mei-Xiu; Zhang, Feng; Wang, Ling -Fang] Nanchang Univ, Inst Translat Med, Natl Engn Res Ctr Bioengn Drugs & Technol, Nanchang 330031, Peoples R China.
C3 Nanchang University
RP Wang, LF (corresponding author), Nanchang Univ, Inst Translat Med, Natl Engn Res Ctr Bioengn Drugs & Technol, Nanchang 330031, Peoples R China.
EM wlfang1985@ncu.edu.cn
RI zhang, feng/L-2587-2013; Qihang, Zhao/AAX-7897-2021
FU National Natural Science Foundation of China [82000354]; Natural Science
   Founda-tion of Jiangxi Province [20212BAB206087, 20212BCJ23043,
   20212BAB216077, 20212BDH81020]; National Nat-ural Science Foundation of
   China [81970256, 82260173, 82200509, 82160094]
FX Funding information This work was supported by the National Natural
   Science Foundation of China (82000354) , the Natural Science Founda-tion
   of Jiangxi Province (20212BAB206087, 20212BCJ23043, 20212BAB216077,
   20212BDH81020) , and the National Nat-ural Science Foundation of China
   (81970256, 82260173, 82200509, 82160094) .
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NR 41
TC 3
Z9 3
U1 6
U2 16
PU CANADIAN SCIENCE PUBLISHING
PI OTTAWA
PA 65 AURIGA DR, SUITE 203, OTTAWA, ON K2E 7W6, CANADA
SN 0008-4212
EI 1205-7541
J9 CAN J PHYSIOL PHARM
JI Can. J. Physiol. Pharmacol.
PD 2023 MAY 16
PY 2023
DI 10.1139/cjpp-2022-0454
EA MAY 2023
PG 13
WC Pharmacology & Pharmacy; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Physiology
GA J1PQ2
UT WOS:001007399700001
PM 37192549
OA hybrid
DA 2025-06-11
ER

PT J
AU Antuña, E
   Cachán-Vega, C
   Bermejo-Millo, JC
   Potes, Y
   Caballero, B
   Vega-Naredo, I
   Coto-Montes, A
   Garcia-Gonzalez, C
AF Antuna, Eduardo
   Cachan-Vega, Cristina
   Carlos Bermejo-Millo, Juan
   Potes, Yaiza
   Caballero, Beatriz
   Vega-Naredo, Ignacio
   Coto-Montes, Ana
   Garcia-Gonzalez, Claudia
TI Inflammaging: Implications in Sarcopenia
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE inflammation; aging; sarcopenia; skeletal muscle
ID TUMOR-NECROSIS-FACTOR; SKELETAL-MUSCLE REGENERATION; ADIPOSE-TISSUE;
   INSULIN-RESISTANCE; SENESCENT CELLS; SATELLITE CELLS; OLDER-ADULTS;
   FACTOR-ALPHA; CROSS-TALK; SYSTEMIC INFLAMMATION
AB In a world in which life expectancy is increasing, understanding and promoting healthy aging becomes a contemporary demand. In the elderly, a sterile, chronic and low-grade systemic inflammation known as "inflammaging" is linked with many age-associated diseases. Considering sarcopenia as a loss of strength and mass of skeletal muscle related to aging, correlations between these two terms have been proposed. Better knowledge of the immune system players in skeletal muscle would help to elucidate their implications in sarcopenia. Characterizing the activators of damage sensors and the downstream effectors explains the inference with skeletal muscle performance. Sarcopenia has also been linked to chronic diseases such as diabetes, metabolic syndrome and obesity. Implications of inflammatory signals from these diseases negatively affect skeletal muscle. Autophagic mechanisms are closely related with the inflammasome, as autophagy eliminates stress signaling sent by damage organelles, but also acts with an immunomodulatory function affecting immune cells and cytokine release. The use of melatonin, an antioxidant, ROS scavenger and immune and autophagy modulator, or senotherapeutic compounds targeting senescent cells could represent strategies to counteract inflammation. This review aims to present the many factors regulating skeletal muscle inflammaging and their major implications in order to understand the molecular mechanisms involved in sarcopenia.
C1 [Antuna, Eduardo; Cachan-Vega, Cristina; Carlos Bermejo-Millo, Juan; Potes, Yaiza; Caballero, Beatriz; Vega-Naredo, Ignacio; Coto-Montes, Ana; Garcia-Gonzalez, Claudia] Inst Invest Sanitaria Principado Asturias ISPA, Av Hosp Univ, Oviedo 33011, Spain.
   [Antuna, Eduardo; Cachan-Vega, Cristina; Carlos Bermejo-Millo, Juan; Potes, Yaiza; Caballero, Beatriz; Vega-Naredo, Ignacio; Coto-Montes, Ana; Garcia-Gonzalez, Claudia] Univ Oviedo, Dept Morphol & Cell Biol, Oviedo 33006, Spain.
   [Antuna, Eduardo; Cachan-Vega, Cristina; Carlos Bermejo-Millo, Juan; Potes, Yaiza; Caballero, Beatriz; Vega-Naredo, Ignacio; Coto-Montes, Ana; Garcia-Gonzalez, Claudia] Inst Neurociencias Principado Asturias INEUROPA, Oviedo 33006, Spain.
C3 Instituto de Investigacion Sanitaria del Principado de Asturias (ISPA);
   University of Oviedo
RP Garcia-Gonzalez, C (corresponding author), Inst Invest Sanitaria Principado Asturias ISPA, Av Hosp Univ, Oviedo 33011, Spain.; Garcia-Gonzalez, C (corresponding author), Univ Oviedo, Dept Morphol & Cell Biol, Oviedo 33006, Spain.; Garcia-Gonzalez, C (corresponding author), Inst Neurociencias Principado Asturias INEUROPA, Oviedo 33006, Spain.
EM claudiacgg@yahoo.es
RI Potes, Yaiza/AAU-2188-2021; Garcia Gonzalez, Claudia/AHA-9573-2022;
   Caballero García, Beatriz/AAC-2636-2020; Vega-Naredo,
   Ignacio/A-4245-2009; COTO-MONTES, ANA/D-2544-2016; Antuna,
   Eduardo/GZH-1194-2022
OI COTO-MONTES, ANA/0000-0002-6609-6258; Antuna,
   Eduardo/0000-0003-1016-6306; Garcia-Gonzalez,
   Claudia/0000-0002-8422-230X; Cachan Vega, Cristina/0000-0001-7244-7862;
   Potes, Yaiza/0000-0002-4687-6230
FU Instituto de Salud Carlos III; Government of the Principado de Asturias
   through the Fundacion para el Fomento en Asturias de la Investigacion
   Cientifica Aplicada y la Tecnologia (FICYT) [FISS-18-PII17/02009,
   PI21/01596, FI18/00149]; European Union, GRUPIN; Instituto de
   Investigacion Sanitaria del Principado de Asturias (ISPA) [FI18/00149,
   IDI/2021/000033]; University of Oviedo [AYUD/2021/9867,
   AYUD/2021/58477]; FICYT-Ayudas Margarita Salas Joven
   [FISS-18-PII17/02009, PI21/01596];  [2021-030-INTRAMURALES-POOCY]; 
   [PAPI-19-EMERG-2];  [PAPI-21-PF-28]
FX This work was supported by the following funding sources: Instituto de
   Salud Carlos III, grant numbers FISS-18-PII17/02009 and PI21/01596; the
   Government of the Principado de Asturias through the Fundacion para el
   Fomento en Asturias de la Investigacion Cientifica Aplicada y la
   Tecnologia (FICYT) and the European Union, GRUPIN grant number
   IDI/2021/000033 and AYUD/2021/9867; the Instituto de Investigacion
   Sanitaria del Principado de Asturias (ISPA), grant number
   AYUD/2021/58477, grant number 2021-030-INTRAMURALES-POOCY University of
   Oviedo and grant number PAPI-19-EMERG-2. E.A. thanks his pre-doctoral
   fellowship to University of Oviedo, grant number PAPI-21-PF-28;
   J.C.B.-M. thanks his pre-doctoral fellowship to Instituto de Salud
   Carlos III, grant number FI18/00149 and C.G.-G. thanks her postdoctoral
   fellowship to FICYT-Ayudas Margarita Salas Joven grant number
   AYUD/2021/58477.
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NR 233
TC 90
Z9 96
U1 5
U2 45
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD DEC
PY 2022
VL 23
IS 23
AR 15039
DI 10.3390/ijms232315039
PG 24
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 6Z0HE
UT WOS:000897464000001
PM 36499366
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Latorre, J
   Díaz-Trelles, R
   Comas, F
   Gavaldà-Navarro, A
   Milbank, E
   Dragano, N
   Morón-Ros, S
   Mukthavaram, R
   Ortega, F
   Castells-Nobau, A
   Oliveras-Cañellas, N
   Ricart, W
   Karmali, PP
   Tachikawa, K
   Chivukula, P
   Villarroya, F
   López, M
   Giralt, M
   Fernández-Real, JM
   Moreno-Navarrete, JM
AF Latorre, Jessica
   Diaz-Trelles, Ramon
   Comas, Ferran
   Gavalda-Navarro, Aleix
   Milbank, Edward
   Dragano, Nathalia
   Moron-Ros, Samantha
   Mukthavaram, Rajesh
   Ortega, Francisco
   Castells-Nobau, Anna
   Oliveras-Canellas, Nuria
   Ricart, Wifredo
   Karmali, Priya P.
   Tachikawa, Kiyoshi
   Chivukula, Pad
   Villarroya, Francesc
   Lopez, Miguel
   Giralt, Marta
   Fernandez-Real, Jose Manuel
   Moreno-Navarrete, Jose Maria
TI Downregulation of hepatic lipopolysaccharide binding protein improves
   lipogenesis-induced liver lipid accumulation
SO MOLECULAR THERAPY-NUCLEIC ACIDS
LA English
DT Article
ID METABOLIC SYNDROME; OBESITY; ASSOCIATION; ENDOTOXEMIA; SEVERITY;
   DISEASE; MARKER; IDH1; MICE; LBP
AB Circulating lipopolysaccharide-binding protein (LBP) is increased in individuals with liver steatosis. We aimed to evaluate the possible impact of liver LBP downregulation using lipid nanoparticle-containing chemically modified LBP small interfering RNA (siRNA) (LNP-Lbp UNA-siRNA) on the development of fatty liver. Weekly LNP-Lbp UNA-siRNA was administered to mice fed a standard chow diet, a high-fat and high-sucrose diet, and a methionine-and choline-deficient diet (MCD). In mice fed a high-fat and high-sucrose diet, which displayed induced liver lipogenesis, LBP downregulation led to reduced liver lipid accumulation, lipogenesis (mainly stearoyl-coenzyme A desaturase 1 [Scd1]) and lipid peroxidation-associated oxidative stress markers. LNP-Lbp UNA-siRNA also resulted in significantly decreased blood glucose levels during an insulin tolerance test. In mice fed a standard chow diet or an MCD, in which liver lipogenesis was not induced or was inhibited (especially Scd1 mRNA), liver LBP downregulation did not impact on liver steatosis. The link between hepatocyte LBP and lipo-genesis was further confirmed in palmitate-treated Hepa1-6 cells, in primary human hepatocytes, and in subjects with morbid obesity. Altogether, these data indicate that siRNA against liver Lbp mRNA constitutes a potential target therapy for obesity-associated fatty liver through the modulation of hepatic Scd1.
C1 [Latorre, Jessica; Comas, Ferran; Ortega, Francisco; Castells-Nobau, Anna; Oliveras-Canellas, Nuria; Ricart, Wifredo; Fernandez-Real, Jose Manuel; Moreno-Navarrete, Jose Maria] CIBEROBN CB06 03 010, Inst Invest Biomed Girona IdIBGi, Dept Diabet Endocrinol & Nutr, Girona 17007, Spain.
   [Latorre, Jessica; Comas, Ferran; Ortega, Francisco; Castells-Nobau, Anna; Oliveras-Canellas, Nuria; Ricart, Wifredo; Fernandez-Real, Jose Manuel; Moreno-Navarrete, Jose Maria] Inst Salud Carlos III ISCIII, Girona 17007, Spain.
   [Latorre, Jessica; Comas, Ferran; Gavalda-Navarro, Aleix; Milbank, Edward; Dragano, Nathalia; Ortega, Francisco; Castells-Nobau, Anna; Oliveras-Canellas, Nuria; Ricart, Wifredo; Villarroya, Francesc; Lopez, Miguel; Giralt, Marta; Fernandez-Real, Jose Manuel; Moreno-Navarrete, Jose Maria] CIBER Fisiopatol Obesidad & Nutr CIBERobn, Madrid 28029, Spain.
   [Diaz-Trelles, Ramon; Mukthavaram, Rajesh; Karmali, Priya P.; Tachikawa, Kiyoshi; Chivukula, Pad] Arcturus Therapeut, San Diego, CA 92121 USA.
   [Gavalda-Navarro, Aleix; Moron-Ros, Samantha; Villarroya, Francesc; Giralt, Marta] Univ Barcelona, CIBEROBN CB06 03 025, Fac Biol, Dept Biochem & Mol Biomed, Barcelona 08028, Catalonia, Spain.
   [Gavalda-Navarro, Aleix; Moron-Ros, Samantha; Villarroya, Francesc; Giralt, Marta] Univ Barcelona, CIBEROBN CB06 03 025, Inst Biomed IBUB, Barcelona 08028, Catalonia, Spain.
   [Milbank, Edward; Dragano, Nathalia; Lopez, Miguel] Univ Santiago de Compostela, Inst Invest Sanitaria, CIMUS, NeurObes Grp,Dept Physiol, Santiago De Compostela 15782, Spain.
   [Fernandez-Real, Jose Manuel] Univ Girona, Dept Med, Girona 17003, Spain.
C3 Universitat de Girona; Girona University Hospital Dr. Josep Trueta;
   Institut d'Investigacio Biomedica de Girona (IDIBGI); CIBER - Centro de
   Investigacion Biomedica en Red; CIBEROBN; CIBER - Centro de
   Investigacion Biomedica en Red; CIBEROBN; University of Barcelona;
   University of Barcelona; Universidade de Santiago de Compostela;
   Universitat de Girona
RP Moreno-Navarrete, JM (corresponding author), CIBEROBN CB06 03 010, Inst Invest Biomed Girona IdIBGi, Dept Diabet Endocrinol & Nutr, Girona 17007, Spain.; Moreno-Navarrete, JM (corresponding author), Inst Salud Carlos III ISCIII, Girona 17007, Spain.
EM jmoreno@idibgi.org
RI Comas, Ferran/AGZ-8744-2022; Villarroya, Francesc/K-4357-2014; Castells,
   Anna/AAA-3846-2020; DRAGANO, NATHALIA/ABA-4367-2020; Morón-Ros,
   Samantha/AAB-1959-2021; MILBANK, Edward/ABF-5946-2021; Gavaldà-Navarro,
   Aleix/C-5074-2017; Fernández-Real, Jose Manuel/AGH-3599-2022; Lopez,
   Miguel/ABF-4844-2021; Moreno-Navarrete, Jose Maria/H-9772-2015; Giralt,
   Marta/A-4756-2013
OI Lopez, Miguel/0000-0002-7823-1648; Dragano,
   Nathalia/0000-0002-6856-5468; Comas Vila, Ferran/0000-0003-1801-3291;
   Castells-Nobau, Anna/0000-0002-6024-8353; Moreno-Navarrete, Jose
   Maria/0000-0002-2883-511X; Moron-Ros, Samantha/0000-0002-6205-2442;
   Oliveras Canellas, Nuria/0000-0002-7758-3326; Gavalda-Navarro,
   Aleix/0000-0001-8421-3174; Latorre Luque, Jessica/0000-0002-7603-1458;
   Giralt, Marta/0000-0001-7968-4190
FU Institutode Salud Carlos III from Spain [PI16/02173, PI16/01173,
   PI19/01712]; FEDER funds; Fundacio Marato de TV3 [201612-30, 201612-31]
FX We acknowledge the technical assistance of Oscar Rovira (IdIBGi) inhuman
   sample collection and Javier Palacios (Parc Cientific de Barce-lona) and
   Fernando J. Perez Asensio (Parc Cientific de Barcelona) inmice
   experiments. This work was partially supported by research grants
   PI16/02173, PI16/01173, and PI19/01712 from the Institutode Salud Carlos
   III from Spain, FEDER funds, and was also supported by Fundacio Marato
   de TV3 (201612-30 and 201612-31).CIBEROBN Fisiopatologia de la Obesidad
   y Nutricion is an initiative from the Instituto de Salud Carlos III from
   Spain.
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NR 44
TC 12
Z9 13
U1 2
U2 23
PU CELL PRESS
PI CAMBRIDGE
PA 50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA
SN 2162-2531
J9 MOL THER-NUCL ACIDS
JI Mol. Ther.-Nucl. Acids
PD SEP 13
PY 2022
VL 29
BP 599
EP 613
DI 10.1016/j.omtn.2022.08.003
EA AUG 2022
PG 15
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 4X3BA
UT WOS:000860720100007
PM 36090751
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Ruiz-Malagón, AJ
   Rodríguez-Sojo, MJ
   Hidalgo-García, L
   Molina-Tijeras, JA
   García, F
   Pischel, I
   Romero, M
   Duarte, J
   Diez-Echave, P
   Rodríguez-Cabezas, ME
   Rodríguez-Nogales, A
   Gálvez, J
AF Jesus Ruiz-Malagon, Antonio
   Jesus Rodriguez-Sojo, Maria
   Hidalgo-Garcia, Laura
   Alberto Molina-Tijeras, Jose
   Garcia, Federico
   Pischel, Ivo
   Romero, Miguel
   Duarte, Juan
   Diez-Echave, Patricia
   Elena Rodriguez-Cabezas, Maria
   Rodriguez-Nogales, Alba
   Galvez, Julio
TI The Antioxidant Activity of Thymus serpyllum Extract Protects
   against the Inflammatory State and Modulates Gut Dysbiosis in
   Diet-Induced Obesity in Mice
SO ANTIOXIDANTS
LA English
DT Article
DE Thymus serpyllum; high fat diet; obesity; antioxidant;
   anti-inflammatory; gut microbiota
ID HUMAN ADIPOSE-TISSUE; MICROBIOTA COMPOSITION; INSULIN-RESISTANCE;
   EXPRESSION; INDIVIDUALS; STRESS; CELLS; LIVER; MODEL; FAT
AB Nowadays, there is an increasing interest in alternative therapies in the treatment of metabolic syndrome that combine efficacy and safety profiles. Therefore, this study aimed to evaluate the effect of an extract of Thymus serpyllum, containing rosmarinic acid, on high-fat diet (HFD)-induced obesity mice, highlighting the impact of its antioxidant activity on the inflammatory status and gut dysbiosis. The extract was administered daily (50, 100 and 150 mg/kg) in HFD-fed mice. The treatment reduced body weight gain, glucose and lipid metabolic profiles. Moreover, the extract ameliorated the inflammatory status, with the c-Jun N-terminal kinases (JUNK) pathway being involved, and showed a significant antioxidant effect by the reduction of radical scavenging activity and the mitigation of lipid peroxidation. Moreover, the extract was able to modulate the altered gut microbiota, restoring microbial richness and diversity, and augmenting the counts of short-chain fatty acid producing bacteria, which have been associated with the maintenance of gut permeability and weight regulation. In conclusion, the antioxidant activity of Thymus serpyllum extract displayed a positive impact on obesity and its metabolic alterations, also reducing systemic inflammation. These effects may be mediated by modulation of the gut microbiota.
C1 [Jesus Ruiz-Malagon, Antonio; Jesus Rodriguez-Sojo, Maria; Hidalgo-Garcia, Laura; Alberto Molina-Tijeras, Jose; Romero, Miguel; Duarte, Juan; Diez-Echave, Patricia; Elena Rodriguez-Cabezas, Maria; Rodriguez-Nogales, Alba; Galvez, Julio] Univ Granada, Ctr Biomed Res CIBM, Dept Pharmacol, Granada 18071, Spain.
   [Jesus Ruiz-Malagon, Antonio; Jesus Rodriguez-Sojo, Maria; Hidalgo-Garcia, Laura; Alberto Molina-Tijeras, Jose; Garcia, Federico; Romero, Miguel; Duarte, Juan; Diez-Echave, Patricia; Elena Rodriguez-Cabezas, Maria; Rodriguez-Nogales, Alba; Galvez, Julio] Inst Invest Biosanitaria Granada Ibs GRANADA, Granada 18012, Spain.
   [Garcia, Federico] Hosp Univ Clin San Cecilio, Serv Microbiol, Granada 18100, Spain.
   [Pischel, Ivo] Univ London, Ctr Pharmacognosy & Phytotherapy, UCL Sch Pharm, London WC1N LAX, England.
   [Romero, Miguel; Duarte, Juan] Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Cardiovasc CIB, Madrid 28029, Spain.
   [Galvez, Julio] Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Hepat & Digest, Madrid 28029, Spain.
C3 University of Granada; Instituto de Investigacion Biosanitaria IBS
   Granada; University of London; University College London; CIBER - Centro
   de Investigacion Biomedica en Red; CIBERCV; Instituto de Salud Carlos
   III; Instituto de Salud Carlos III; CIBER - Centro de Investigacion
   Biomedica en Red; CIBEREHD
RP Diez-Echave, P; Rodríguez-Cabezas, ME (corresponding author), Univ Granada, Ctr Biomed Res CIBM, Dept Pharmacol, Granada 18071, Spain.; Diez-Echave, P; Rodríguez-Cabezas, ME (corresponding author), Inst Invest Biosanitaria Granada Ibs GRANADA, Granada 18012, Spain.
EM ajruiz@ugr.es; mjrodrisojo@correo.ugr.es; lhidgar@ugr.es;
   jalbertomolina@ugr.es; fegarcia@ugr.es; i.pischel@ucl.ac.uk;
   miguelr@ugr.es; jmduarte@ugr.es; diezpatri@ugr.es; merodri@ugr.es;
   albarn@ugr.es; jgalvez@ugr.es
RI Hidalgo-García, Laura/AAD-6209-2020; Garcia, Federico/AAA-3175-2020;
   Tijeras, Jose/AAB-3135-2020; Ruiz Malagón, Antonio Jesús/AAS-3494-2020;
   Rodríguez-Nogales, Alba/J-2782-2017; Duarte, Juan/K-6472-2014; Romero,
   Miguel/K-6053-2014; Galvez, Julio/K-6875-2014; rodriguez-cabezas, maria
   elena/L-3086-2014
OI Duarte, Juan/0000-0002-9153-5857; Rodriguez Sojo, Maria
   Jesus/0000-0002-1693-505X; Romero, Miguel/0000-0003-0578-1099;
   Ruiz-Malagon, Antonio Jesus/0000-0003-4323-650X; Garcia,
   Federico/0000-0001-7611-781X; Galvez, Julio/0000-0001-6876-3782;
   Rodriguez, Alba/0000-0003-1927-0628; Molina Tijeras, Jose
   Alberto/0000-0003-1554-9226; rodriguez-cabezas, maria
   elena/0000-0001-9085-8147; Pischel, Ivo/0000-0003-4111-7726
FU Junta de Andalucia [CTS 164]; Instituto de Salud Carlos III (ISCIII)
   [PI19.01058]; Spanish Ministry of Economy and Competitiveness
   [AGL201567995-C3-3-R]; European Commission (FEDER/ERDF); ISCIII
FX This research was funded by the Junta de Andalucia (CTS 164), by the
   Instituto de Salud Carlos III (ISCIII) (PI19.01058) and by the Spanish
   Ministry of Economy and Competitiveness (AGL201567995-C3-3-R), with
   funds from the European Commission (FEDER/ERDF). The CIBER-EHD is funded
   by the ISCIII. A.J. Ruiz-Malagon and L. Hidalgo-Garcia are predoctoral
   fellows from the University of Granada of "Programa de Doctorado:
   Medicina Clinica y Salud Publica" (Formacion de Profesorado
   Universitario Program); J.A. Molina-Tijeras and M.J. Rodriguez-Sojo are
   predoctoral fellows from ISCIII (pFIS and i-pFIS program, respectively).
   P. Diez-Echave is a postdoctoral fellow from the University of Granada
   (P18-RT-4930).
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NR 73
TC 17
Z9 17
U1 3
U2 11
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD JUN
PY 2022
VL 11
IS 6
AR 1073
DI 10.3390/antiox11061073
PG 24
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA 2K5QS
UT WOS:000816390800001
PM 35739969
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Gnocchi, D
   Custodero, C
   Sabbà, C
   Mazzocca, A
AF Gnocchi, Davide
   Custodero, Carlo
   Sabba, Carlo
   Mazzocca, Antonio
TI Circadian rhythms: a possible new player in non-alcoholic fatty liver
   disease pathophysiology
SO JOURNAL OF MOLECULAR MEDICINE-JMM
LA English
DT Review
DE Non-alcoholic fatty liver disease (NAFLD); Non-alcoholic steatohepatitis
   (NASH); Hepatocellular carcinoma (HCC); Circadian rhythms; Metabolism;
   Metabolic syndrome; Insulin resistance
ID REV-ERB-ALPHA; ENDOPLASMIC-RETICULUM STRESS; GENOME-WIDE ASSOCIATION;
   PERIOD GENE-PRODUCT; SUPRACHIASMATIC NUCLEUS; LIFE-STYLE;
   DROSOPHILA-PERIOD; GUT MICROBIOTA; CLOCK PROTEIN; DRIVING OSCILLATION
AB Over the last decades, a better knowledge of the molecular machinery supervising the regulation of circadian clocks has been achieved, and numerous findings have helped in unravelling the outstanding significance of the molecular clock for the proper regulation of our physiologic and metabolic homeostasis. Non-alcoholic fatty liver disease (NAFLD) is currently considered as one of the emerging liver pathologies in the Western countries due to the modification of eating habits and lifestyle. Although NAFLD is considered a pretty benign condition, it can progress towards non-alcoholic steatohepatitis (NASH) and eventually hepatocellular carcinoma (HCC). The pathogenic mechanisms involved in NAFLD development are complex, since this disease is a multifactorial condition. Major metabolic deregulations along with a genetic background are believed to take part in this process. In this light, the aim of this review is to give a comprehensive description of how our circadian machinery is regulated and to describe to what extent our internal clock is involved in the regulation of hormonal and metabolic homeostasis, and by extension in the development and progression of NAFLD/NASH and eventually in the onset of HCC.
C1 [Gnocchi, Davide; Custodero, Carlo; Sabba, Carlo; Mazzocca, Antonio] Univ Bari, Sch Med, Interdisciplinary Dept Med, Piazza G Cesare 11, I-70124 Bari, Italy.
C3 Universita degli Studi di Bari Aldo Moro
RP Mazzocca, A (corresponding author), Univ Bari, Sch Med, Interdisciplinary Dept Med, Piazza G Cesare 11, I-70124 Bari, Italy.
EM antonio.mazzocca@uniba.it
RI Custodero, Carlo/AAS-4723-2021; Gnocchi, Davide/AAQ-7965-2021; Mazzocca,
   Augustus/AAD-7507-2021
OI MAZZOCCA, Antonio/0000-0003-0940-7352; Custodero,
   Carlo/0000-0003-1549-6451; Gnocchi, Davide/0000-0003-4297-4906
FU AIRC (Italian Association for Cancer Research) Investigator Grant (IG)
   2015 [17758]
FX The work was supported by the AIRC (Italian Association for Cancer
   Research) Investigator Grant (IG) 2015 Id.17758 (to A. Mazzocca).
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NR 247
TC 27
Z9 28
U1 1
U2 15
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0946-2716
EI 1432-1440
J9 J MOL MED
JI J. Mol. Med.
PD JUN
PY 2019
VL 97
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BP 741
EP 759
DI 10.1007/s00109-019-01780-2
PG 19
WC Genetics & Heredity; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Genetics & Heredity; Research & Experimental Medicine
GA HY6YN
UT WOS:000468276900001
PM 30953079
DA 2025-06-11
ER

PT J
AU Nascimbeni, F
   Pellegrini, E
   Lugari, S
   Mondelli, A
   Bursi, S
   Onfiani, G
   Carubbi, F
   Lonardo, A
AF Nascimbeni, Fabio
   Pellegrini, Elisa
   Lugari, Simonetta
   Mondelli, Alberto
   Bursi, Serena
   Onfiani, Giovanna
   Carubbi, Francesca
   Lonardo, Amedeo
TI Statins and nonalcoholic fatty liver disease in the era of precision
   medicine: More friends than foes
SO ATHEROSCLEROSIS
LA English
DT Review
DE Cardiovascular risk; Cirrhosis; HCC; Drug-induced liver injury; NAFLD;
   NASH; Statins
ID COA REDUCTASE INHIBITORS; CORONARY-HEART-DISEASE;
   HEPATOCELLULAR-CARCINOMA; HEPATIC-FIBROSIS; ENDOTHELIAL DYSFUNCTION;
   PORTAL-HYPERTENSION; OXIDATIVE STRESS; REDUCED RISK; OPEN-LABEL;
   ATORVASTATIN
AB Nonalcoholic fatty liver disease (NAFLD) describes a spectrum of alcohol-like hepatic histological changes, which occur in the absence of any competing causes of chronic liver disease, notably including significant alcohol consumption. A close and bi-directional relationship links NAFLD with the metabolic syndrome (MetS), and concurrent MetS will hasten the progression to more severe forms of NAFLD, including cirrhosis and hepatocellular carcinoma (HCC). Patients with NAFLD will typically exhibit atherogenic dyslipidemia and increased cardiovascular risk (CVR).
   Statins are among the most widely prescribed lipid-lowering drugs. Their use has historically been hampered, in individuals with liver disease, owing to the fear of hepatotoxicity. However, studies suggest that statins are not only effective in reducing cardiovascular events, but may also exert multiple beneficial effects on the liver.
   CVR in those with NAFLD has extensively been covered by our group and others. This updated clinical narrative review will critically examine the effects of statins on the pathogenesis of NAFLD, including the key elementary pathological lesions of NAFLD, i. e. steatosis, inflammation and fibrosis, and its liver-related complications, i. e. cirrhosis, portal hypertension and HCC.
C1 [Nascimbeni, Fabio; Pellegrini, Elisa; Lonardo, Amedeo] Azienda Osped Univ Modena, Civil Hosp Baggiovara, Operating Unit Internal & Metab Med, Via Giardini 1355, I-41126 Modena, Italy.
   [Lugari, Simonetta; Mondelli, Alberto; Bursi, Serena; Onfiani, Giovanna; Carubbi, Francesca] Azienda Osped Univ Modena, Operating Unit Internal & Metab Med, Via Giardini 1355, I-41126 Modena, Italy.
   [Lugari, Simonetta; Mondelli, Alberto; Bursi, Serena; Onfiani, Giovanna; Carubbi, Francesca] Univ Modena & Reggio Emilia, Civil Hosp Baggiovara, Via Giardini 1355, I-41126 Modena, Italy.
C3 Universita di Modena e Reggio Emilia; Universita di Modena e Reggio
   Emilia Hospital; Universita di Modena e Reggio Emilia; Universita di
   Modena e Reggio Emilia Hospital; Universita di Modena e Reggio Emilia
RP Nascimbeni, F (corresponding author), Azienda Osped Univ Modena, Civil Hosp Baggiovara, Operating Unit Internal & Metab Med, Via Giardini 1355, I-41126 Modena, Italy.
EM fabio.nascimbeni@libero.it
RI Carubbi, Francesca/P-3973-2015; Lonardo, Amedeo/I-5911-2019
OI Nascimbeni, Fabio/0000-0002-1051-1272; Lonardo,
   Amedeo/0000-0001-9886-0698
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NR 109
TC 68
Z9 72
U1 0
U2 18
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0021-9150
EI 1879-1484
J9 ATHEROSCLEROSIS
JI Atherosclerosis
PD MAY
PY 2019
VL 284
BP 66
EP 74
DI 10.1016/j.atherosclerosis.2019.02.028
PG 9
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA HV7IT
UT WOS:000466155400010
PM 30875495
DA 2025-06-11
ER

PT J
AU Huang, JQ
   Wang, XQ
   Tao, GY
   Song, Y
   Ho, CT
   Zheng, J
   Ou, SY
AF Huang, Junqing
   Wang, Xiaoqi
   Tao, Guanyu
   Song, Yuan
   Ho, Chitang
   Zheng, Jie
   Ou, Shiyi
TI Feruloylated oligosaccharides from maize bran alleviate the symptoms of
   diabetes in streptozotocin-induced type 2 diabetic rats
SO FOOD & FUNCTION
LA English
DT Article
ID GLYCATION END-PRODUCTS; OXIDATIVE STRESS; FERULIC ACID;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; INFLAMMATION; MELLITUS;
   ATHEROSCLEROSIS; DISEASE; TISSUE
AB This study investigated the therapeutic effect of feruloylated oligosaccharides (FOs) extracted from maize bran on type 2 diabetic rats and its potential mechanism. Streptozotocin (STZ) induced type 2 diabetic male rats were orally administered with different levels of FOs for 8 weeks, and ferulic acid (FA) treatment was conducted as the positive control. Among all the treatments, the oral administration of 600 mg per kg bw per d FOs showed the best therapeutic effects on the diabetic rats by significantly lowering the levels of fasting plasma glucose (FPG), fasting insulin, TG, LDL-c, aspartate transaminase, creatine kinase and lactate dehydrogenase in plasma, while increasing the level of plasma HDL-c. In addition, the intake of FOs at 600 mg per kg bw per d exhibited the best antioxidant effects in the plasma, liver, kidney and heart of the diabetic rats, and the highest inhibitory effects on the formation of AGEs and CML in the organs, which might explain the alleviating effects of FOs on abdominal aorta injury observed in the current study. FOs presented better regulation effects on FPG, plasma lipid and the protection of abdominal aorta than FA under the same administered dosage. Based on these outcomes, FOs from maize bran could be beneficial for prevention or early treatment of diabetes mellitus.
C1 [Huang, Junqing] Jinan Univ, Coll Tradit Chinese Med, Guangzhou 510632, Guangdong, Peoples R China.
   [Wang, Xiaoqi; Ho, Chitang] Rutgers State Univ, Dept Food Sci, 65 Dudley Rd, New Brunswick, NJ 08901 USA.
   [Tao, Guanyu] Texas Tech Univ, Hlth Sci Ctr, Sch Pharm, Dept Pharmaceut Sci, Amarillo, TX 79106 USA.
   [Song, Yuan] Tina? Univ, Affiliated Hosp 1, Out Patient Dept Univ, Guangzhou 510632, Guangdong, Peoples R China.
   [Zheng, Jie; Ou, Shiyi] Jinan Univ, Dept Food Sci & Engn, Guangzhou 510632, Guangdong, Peoples R China.
C3 Jinan University; Rutgers University System; Rutgers University New
   Brunswick; Texas Tech University System; Texas Tech University Health
   Sciences Center Lubbock; Texas Tech University Health Sciences Center
   Amarillo; Jinan University
RP Zheng, J; Ou, SY (corresponding author), Jinan Univ, Dept Food Sci & Engn, Guangzhou 510632, Guangdong, Peoples R China.
EM zhengjie@jnu.edu.cn; tosy@jnu.edu.cn
RI Tao, Gabriel/ABH-9336-2022; Ho, Chi-Tang/B-5629-2012
OI Zheng, Jie/0000-0001-9755-5595; Tao, Gabriel/0000-0002-5799-3539; Wang,
   Xiaoqi/0000-0002-2917-8174
FU National Natural Science Foundation of China [31701594]; First
   Affiliated Hospital of Jinan University [2016319]; China Scholarship
   Council [201706780027]
FX This work was supported by the National Natural Science Foundation of
   China [grant number 31701594], the First Affiliated Hospital of Jinan
   University [grant number 2016319], and the China Scholarship Council
   [grant number 201706780027].
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NR 48
TC 36
Z9 38
U1 1
U2 75
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PD MAR
PY 2018
VL 9
IS 3
BP 1779
EP 1789
DI 10.1039/c7fo01825h
PG 11
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA GF1TB
UT WOS:000431717400041
PM 29508881
DA 2025-06-11
ER

PT S
AU Sharma, G
   Prossnitz, ER
AF Sharma, Geetanjali
   Prossnitz, Eric R.
BE MauvaisJarvis, F
TI G-Protein-Coupled Estrogen Receptor (GPER) and Sex-Specific Metabolic
   Homeostasis
SO SEX AND GENDER FACTORS AFFECTING METABOLIC HOMEOSTASIS, DIABETES AND
   OBESITY
SE Advances in Experimental Medicine and Biology
LA English
DT Article; Book Chapter
ID MITOTIC CLONAL EXPANSION; GROWTH-FACTOR RECEPTOR; PANCREATIC BETA-CELLS;
   BODY-FAT DISTRIBUTION; INSULIN-RESISTANCE; OXIDATIVE STRESS;
   POSTMENOPAUSAL WOMEN; GLUCOSE-TOLERANCE; ADIPOSE-TISSUE;
   GENDER-DIFFERENCES
AB Obesity and metabolic syndrome display disparate prevalence and -regulation between males and females. Human, as well as rodent, females with regular menstrual/estrous cycles exhibit protection from weight gain and associated chronic diseases. These beneficial effects are predominantly attributed to the female hormone estrogen, specifically 17 beta-estradiol (E2). E2 exerts its actions via multiple receptors, nuclear and extranuclear estrogen receptor (ER) alpha and ER beta, and the G-protein-coupled estrogen receptor (GPER, previously termed GPR30). The roles of GPER in metabolic homeostasis are beginning to emerge but are complex and remain unclear. The discovery of GPER-selective pharmacological agents (agonists and antagonists) and the availability of GPER knockout mice have significantly enhanced our understanding of the functions of GPER in normal physiology and disease. GPER action manifests pleiotropic effects in metabolically active tissues such as the pancreas, adipose, liver, and skeletal muscle. Cellular and animal studies have established that GPER is involved in the regulation of body weight, feeding behavior, inflammation, as well as glucose and lipid homeostasis. GPER deficiency leads to increased adiposity, insulin resistance, and metabolic dysfunction in mice. In contrast, pharmacologic stimulation of GPER in vivo limits weight gain and improves metabolic output, revealing a promising novel therapeutic potential for the treatment of obesity and diabetes.
C1 [Sharma, Geetanjali] Univ New Mexico, Hlth Sci Ctr, Dept Internal Med, Div Mol Med, Albuquerque, NM 87131 USA.
   [Prossnitz, Eric R.] Univ New Mexico, Inflammat & Metab Ctr Biomed Res Excellence, Hlth Sci Ctr, Div Mol Med,Dept Internal Med & Autophagy, Albuquerque, NM 87131 USA.
   [Prossnitz, Eric R.] Univ New Mexico, Hlth Sci Ctr, Ctr Comprehens Canc, Albuquerque, NM 87131 USA.
C3 University of New Mexico's Health Sciences Center; University of New
   Mexico; University of New Mexico; University of New Mexico's Health
   Sciences Center; University of New Mexico; University of New Mexico's
   Health Sciences Center
RP Sharma, G (corresponding author), Univ New Mexico, Hlth Sci Ctr, Dept Internal Med, Div Mol Med, Albuquerque, NM 87131 USA.; Prossnitz, ER (corresponding author), Univ New Mexico, Inflammat & Metab Ctr Biomed Res Excellence, Hlth Sci Ctr, Div Mol Med,Dept Internal Med & Autophagy, Albuquerque, NM 87131 USA.; Prossnitz, ER (corresponding author), Univ New Mexico, Hlth Sci Ctr, Ctr Comprehens Canc, Albuquerque, NM 87131 USA.
EM gsharma@salud.unm.edu; eprossnitz@salud.unm.edu
RI Prossnitz, Eric/B-4543-2008
OI Prossnitz, Eric/0000-0001-9190-8302
FU National Institutes of Health [NIH R01 CA127731, CA163890, CA194496];
   Dialysis Clinic, Inc.; UNM Comprehensive Cancer Center [P30 CA118100]
FX The authors were supported by research grants from the National
   Institutes of Health (NIH R01 CA127731, CA163890, and CA194496 to ERP),
   Dialysis Clinic, Inc. (to ERP), and by the UNM Comprehensive Cancer
   Center (P30 CA118100).
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NR 178
TC 71
Z9 75
U1 0
U2 12
PU SPRINGER INTERNATIONAL PUBLISHING AG
PI CHAM
PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND
SN 0065-2598
EI 2214-8019
BN 978-3-319-70178-3; 978-3-319-70177-6
J9 ADV EXP MED BIOL
JI Adv.Exp.Med.Biol.
PY 2017
VL 1043
BP 427
EP 453
DI 10.1007/978-3-319-70178-3_20
D2 10.1007/978-3-319-70178-3
PG 27
WC Biochemical Research Methods; Biochemistry & Molecular Biology;
   Endocrinology & Metabolism; Medicine, Research & Experimental
WE Book Citation Index – Science (BKCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism; Research &
   Experimental Medicine
GA BS3UO
UT WOS:000715520200023
PM 29224106
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Kumar, M
   Kaur, H
   Mani, V
   Gupta, N
   Tyagi, AK
   Kushwaha, R
AF Kumar, M.
   Kaur, H.
   Mani, V.
   Gupta, N.
   Tyagi, A. K.
   Kushwaha, R.
TI Ameliorating proliferation and superoxide dismutase mRNA expression of
   cadmium exposed leukocytes through copper treatment in transitional
   dairy cows
SO INDIAN JOURNAL OF ANIMAL SCIENCES
LA English
DT Article
DE Cadmium; Copper; Lymphocytes proliferation; mRNA expression; Superoxide
   dismutase
ID OXIDATIVE STRESS; METABOLIC SYNDROME; PERIPHERAL-BLOOD; DIETARY COPPER;
   LYMPHOCYTES; MICE; RATS; PERFORMANCE; LACTATION; GROWTH
AB The study was conducted to determine the effect of cadmium on lymphocyte proliferation and mRNA superoxide dismutase (SOD) expression and to evaluate whether copper treatment in Cd exposed lymphocytes can modulate their proliferation and SOD mRNA expression. Blood samples were collected from crossbred transitional dairy cows at -30, -15, 0, 15, and 30 days of calving and evaluated for lymphocytes proliferation and SOD expression. A fixed number of lymphocyte were cultured for 72 h with 10(-3), 10(-4), 10(-5) and 10(-6) M levels of Cd. Effect of different Cd levels on proliferation and mRNA SOD expression was counteracted by 30, 35 and 40 mu M Cu. Mitogenic response of lymphocyte and mRNA expression of SOD reduced as the days of parturition advanced and was noted lowest at the day of calving. Lymphocyte proliferation and mRNA SOD expression showed negative correlation with Cd levels. Addition of Cu in the Cd exposed lymphocyte culture improved lymphocyte proliferation and relative abundance of SOD mRNA expression and increase was reported highest in 40 mu M Cu treated lymphocytes. These results indicated that Cu can ameliorate adverse effect of Cd on lymphocyte proliferation and SOD expression in transitional dairy cows.
C1 [Kumar, M.; Kaur, H.; Mani, V.; Gupta, N.; Tyagi, A. K.; Kushwaha, R.] ICAR Natl Dairy Res Inst, Karnal 132001, Haryana, India.
   [Kumar, M.; Kushwaha, R.] DUVASU, Coll Vet Sci & Anim Husb, Dept Anim Nutr, Mathura, India.
   [Kaur, H.] Indian Council Agr Res, Agr Extens Div, KAB I, New Delhi, India.
   [Mani, V.; Tyagi, A. K.] Dairy Cattle Nutr Div, Karnal, Haryana, India.
   [Gupta, N.] Natl Bur Anim Genet Resources, Karnal, Haryana, India.
C3 Indian Council of Agricultural Research (ICAR); ICAR - National Dairy
   Research Institute; U.P. Pandit Deen Dayal Upadhyaya Pashu Chikitsa
   Vigyan Vishwavidyalaya Evam Go; Indian Council of Agricultural Research
   (ICAR); Indian Council of Agricultural Research (ICAR); ICAR - National
   Dairy Research Institute; Indian Council of Agricultural Research
   (ICAR); ICAR - National Bureau of Animal Genetic Resources
RP Kumar, M (corresponding author), ICAR Natl Dairy Res Inst, Karnal 132001, Haryana, India.; Kumar, M (corresponding author), DUVASU, Coll Vet Sci & Anim Husb, Dept Anim Nutr, Mathura, India.
EM muneendra82@gmail.com; harjit1955@gmail.com; veenamani1@yahoo.com;
   neelamgnbagr@gmail.com; amrishtyagi1963@yahoo.com; rajuvet15@gmail.com
FU Indian Council of Agricultural Research, Pusa, New Delhi, India
FX The financial support for this study was provided by Indian Council of
   Agricultural Research, Pusa, New Delhi, India. We would like to thank
   National Bureau of Animal Genetic Resources, Karnal, India for providing
   facilities for determination of superoxide dismutase expression.
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NR 34
TC 0
Z9 0
U1 0
U2 0
PU INDIAN COUNC AGRICULTURAL RES
PI NEW DELHI
PA KAB-1, NEW DELHI 110012, INDIA
SN 0367-8318
J9 INDIAN J ANIM SCI
JI Indian J. Anim. Sci.
PD AUG
PY 2016
VL 86
IS 8
BP 873
EP 877
PG 5
WC Agriculture, Dairy & Animal Science
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture
GA DU6VQ
UT WOS:000382353100005
DA 2025-06-11
ER

PT J
AU Macharia, M
   Kengne, AP
   Blackhurst, DM
   Erasmus, RT
   Hoffmann, M
   Matsha, TE
AF Macharia, M.
   Kengne, A. P.
   Blackhurst, D. M.
   Erasmus, R. T.
   Hoffmann, M.
   Matsha, T. E.
TI Indices of Paraoxonase and Oxidative Status Do Not Enhance the
   Prediction of Subclinical Cardiovascular Disease in Mixed-Ancestry South
   Africans
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Article
ID LOW-DENSITY-LIPOPROTEIN; SERUM-AMYLOID-A; DIABETES-MELLITUS;
   HEART-DISEASE; COLORED POPULATION; METABOLIC SYNDROME; RISK-FACTORS;
   STRESS; INFLAMMATION; PON1
AB We evaluated the association of indices of paraoxonase (PON1) and oxidative status with subclinical cardiovascular disease (CVD) in mixed-ancestry South Africans. Participants were 491 adults (126 men) who were stratified by diabetes status and body mass index (BMI). Carotid intima-media thickness (CIMT) was used as a measure of subclinical CVD. Indices of PON1 and oxidative status were determined by measuring levels and activities (paraoxonase and arylesterase) of PON1, antioxidant activity (ferric reducing antioxidant power and trolox equivalent antioxidant capacity), and lipid peroxidation markers (malondialdehyde and oxidized LDL). Diabetic subjects (28.9%) displayed a significant decrease in PON1 status and antioxidant activity as well as increase in oxidized LDL and malondialdehyde. A similar profile was apparent across increasing BMI categories. CIMT was higher in diabetic than nondiabetic subjects (P < 0.0001) but showed no variation across BMI categories. Overall, CIMT correlated negatively with indices of antioxidant activity and positively with measures of lipid oxidation. Sex, age, BMI, and diabetes altogether explained 29.2% of CIMT, with no further improvement from adding PON1 and/or antioxidant status indices. Though indices of PON1 and oxidative status correlate with CIMT, their measurements may not be useful for identifying subjects at high CVD risk in this population.
C1 [Macharia, M.; Erasmus, R. T.; Hoffmann, M.] NHLS, Fac Hlth Sci, Div Chem Pathol, Cape Town, South Africa.
   [Macharia, M.; Erasmus, R. T.; Hoffmann, M.] Univ Stellenbosch, Cape Town, South Africa.
   [Kengne, A. P.] South African Med Res Council, NCRP Cardiovasc & Metab Dis, Cape Town, South Africa.
   [Kengne, A. P.] Univ Cape Town, ZA-7925 Cape Town, South Africa.
   [Blackhurst, D. M.] Univ Cape Town, Div Chem Pathol, ZA-7925 Cape Town, South Africa.
   [Matsha, T. E.] Cape Peninsula Univ Technol, Fac Hlth & Wellness Sci, Dept Biomed Sci, ZA-7530 Cape Town, South Africa.
C3 Stellenbosch University; South African Medical Research Council;
   University of Cape Town; University of Cape Town; Cape Peninsula
   University of Technology
RP Matsha, TE (corresponding author), Cape Peninsula Univ Technol, Fac Hlth & Wellness Sci, Dept Biomed Sci, POB 1906, ZA-7530 Cape Town, South Africa.
EM matshat@cput.ac.za
RI Kengne, Andre/ABB-3696-2020
OI Matsha, Tandi/0000-0001-5251-030X; Kengne, Andre
   Pascal/0000-0002-5183-131X; Macharia, Muiruri/0000-0002-5508-274X
FU University Research Fund of the Cape Peninsula University of Technology,
   South Africa; South African Medical Research Council; Harry Crossley
   Foundation; University of Stellenbosch
FX The authors would like to thank the Bellville South Community of Cape
   Town, South Africa. This study was funded by the University Research
   Fund of the Cape Peninsula University of Technology, South Africa, South
   African Medical Research Council, Harry Crossley Foundation, and
   University of Stellenbosch.
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NR 38
TC 5
Z9 5
U1 0
U2 5
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PY 2014
VL 2014
AR 135650
DI 10.1155/2014/135650
PG 10
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA AE4TF
UT WOS:000333975500001
PM 24799979
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Park, CH
   Jeong, SJ
   Lee, HJ
   Lee, EO
   Bae, H
   Lee, MH
   Kim, SH
   Jung, HJ
   Ahn, KS
   Kim, SH
AF Park, Cheol-Hwan
   Jeong, Soo-Jin
   Lee, Hyo-Jeong
   Lee, Eun-Ok
   Bae, Hyunsu
   Lee, Min-Ho
   Kim, Sun-Hyung
   Jung, Hee-Jae
   Ahn, Kyoo Seok
   Kim, Sung-Hoon
TI Traditional Medicine Taeeumjowitangkagambang Exerts Antiobesity and
   Hypolipidemic Effects via Antioxidant Enzyme Enhancement
SO PHYTOTHERAPY RESEARCH
LA English
DT Article
DE Taeeumjowitangkagambang; obesity; hyperlipidemia; antioxidant enzymes
ID INCREASED OXIDATIVE STRESS; LACHRYMAJOBI VAR. MAYUEN;
   SUPEROXIDE-DISMUTASE; METABOLIC SYNDROME; BODY-WEIGHT; OBESITY; LEPTIN;
   SERUM; ASSAY; DRUGS
AB Taeeumjowitangkagambang (ETJKB) is a traditional Korean medicine that has been clinically used for obesity with little mechanistic understanding. The present study investigated antiobesity and hypolipidemic effects of ETJKB in high fat diet fed rats as well as a 3T3-L1 pre-adipocyte differentiation model. ETJKB significantly inhibited the lipidogenesis in 3T3-L1 adipocytes in a concentration-dependent manner as well as reduced the cellular adipokine leptin level. Daily oral gavage of ETJKB to rats fed a high fat diet significantly attenuated body weight gain and abdominal and epididymal fat weights. ETJKB treatment also reduced the levels of total cholesterol, low density lipoprotein (LDL) and triglyceride as well as increased high density lipoprotein (HDL) in serum compared with the untreated control. Similarly, the ETJKB treatment decreased the levels of total lipid, triglyceride and cholesterol in liver tissue in high fat diet fed rats. Interestingly, ETJKB significantly increased the activities of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and catalase in liver tissue, while decreasing the hydroxyl radical, thiobarbituric acid reactive substances (TBARS), carbonyl concentration. An improvement of antioxidant enzymes was associated with improved body weight control and healthier lipid profiles and therefore may play an important role in the antiobesity and hypolipidemic effects of ETJKB. Copyright (C) 2010 John Wiley & Sons, Ltd.
C1 [Kim, Sung-Hoon] Kyung Hee Univ, Canc Prevent Mat Dev Res Ctr, Coll Oriental Med, Seoul 130701, South Korea.
   [Lee, Min-Ho] Kyung Hee Univ, Coll Life Sci, Seoul 130701, South Korea.
C3 Kyung Hee University; Kyung Hee University
RP Kim, SH (corresponding author), Kyung Hee Univ, Canc Prevent Mat Dev Res Ctr, Coll Oriental Med, 1 Hoegidong, Seoul 130701, South Korea.
EM sungkim7@khu.ac.kr
RI Kim, Sung/C-9604-2011
OI kim, sunghoon/0000-0002-1570-3230; Bae, Hyunsu/0000-0002-0299-3582
FU Korea government (MEST) [2009-0063466]
FX This work was supported by the Korea Science and Engineering Foundation
   (KOSEF) grant funded by the Korea government (MEST) (No. 2009-0063466).
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NR 39
TC 11
Z9 11
U1 0
U2 7
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0951-418X
J9 PHYTOTHER RES
JI Phytother. Res.
PD NOV
PY 2010
VL 24
IS 11
BP 1700
EP 1709
DI 10.1002/ptr.3179
PG 10
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 675AA
UT WOS:000283794300021
PM 21031632
DA 2025-06-11
ER

PT J
AU Tschoepe, D
   Stratmann, B
AF Tschoepe, Diethelm
   Stratmann, Bernd
TI Plaque stability and plaque regression: new insights
SO EUROPEAN HEART JOURNAL SUPPLEMENTS
LA English
DT Article; Proceedings Paper
CT 2nd International Merck Symposium on HDL-Cholesterol Raising - Bridging
   the Gap in Cardiovascular Risk Reduction
CY OCT 14-15, 2005
CL Barcelona, SPAIN
DE atherosclerosis; diabetes; dyslipidaemia; cardiovascular risk factors;
   HDL-cholesterol; metabolic syndrome
ID DENSITY-LIPOPROTEIN CHOLESTEROL; CORONARY-ARTERY DISEASE; ASSOCIATION
   TASK-FORCE; AMERICAN-COLLEGE; FOLLOW-UP; ATHEROSCLEROSIS; PREVENTION;
   PROGRESSION; GUIDELINES; COMMITTEE
AB Patients with prior cardiovascular disease and/or diabetes are at the highest risk of a myocardial infarction or stroke. Thus, the majority of morbid cardiovascular events arise in the large population of patients with qualifying risk factors, according to standard risk factor scoring techniques. Angiography studies suggest that a substantial proportion of myocardial infarctions arise in vessels without severe atherosclerotic stenosis on initial examination. The rupture of the fibrous cap of the mature atherosclerotic plaque usually initiates intra-arterial thrombosis and is rendered more likely by additional factors such as inflammation, hyperglycaemic spikes, and mechanical or shear stress in the artery wall. The vulnerability of plaques to rupture is therefore an important determinant of outcome, and treatment strategies in patients with cardiovascular disease should address this issue. Continuing improvements in cardiac-imaging techniques raise the possibility of routine assessment of plaque stability in the future, which will facilitate the identification of vulnerable plaques and the delivery of appropriate treatment. Recent evidence from a large observational study suggests that low HDL-chotesterol not only drives atherosclerosis progression but also increases plaque vulnerability. Correcting tow HDL-cholesterol, for example, with nicotinic acid or a fibrate, appears a rational strategy for addressing the continuing burden of atherothrombotic disease.
C1 Ruhr Univ Bochum, Univ Clin, Diabet Ctr, Heart & Diabet Ctr, D-32545 Bad Oeynhausen, Germany.
C3 Ruhr University Bochum
RP Tschoepe, D (corresponding author), Ruhr Univ Bochum, Univ Clin, Diabet Ctr, Heart & Diabet Ctr, Georg Str 11, D-32545 Bad Oeynhausen, Germany.
EM ieickhoff@hdz-nrw.de
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NR 40
TC 4
Z9 4
U1 0
U2 5
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1520-765X
EI 1554-2815
J9 EUR HEART J SUPPL
JI Eur. Heart J. Suppl.
PD OCT
PY 2006
VL 8
IS F
BP F34
EP F39
DI 10.1093/eurheartj/sul039
PG 6
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Cardiovascular System & Cardiology
GA 099XU
UT WOS:000241631900008
OA Bronze
DA 2025-06-11
ER

PT J
AU Wang, QZ
   Zhang, YJ
   Lu, RL
   Zhao, QW
   Gao, Y
AF Wang, Qianzhuo
   Zhang, Yingjuan
   Lu, Ruiling
   Zhao, Qingwen
   Gao, Yue
TI The multiple mechanisms and therapeutic significance of rutin in
   metabolic dysfunction-associated fatty liver disease (MAFLD)
SO FITOTERAPIA
LA English
DT Review
DE Rutin; Metabolic dysfunction-associated fatty liver; disease; Signaling
   pathway; Therapy
ID ANTIOXIDANT PROPERTIES; DOUBLE-BLIND; OBESITY
AB The global incidence of metabolic dysfunction-associated fatty liver disease (MAFLD) has been steadily increasing, making it a leading chronic liver disease. MAFLD refers to a metabolic syndrome linked with type 2 diabetes mellitus, obesity. However, its pathophysiology is complex, there are currently no effective and approved medicines for therapy. Rutin, a naturally occurring polyphenolic flavonoid, is widely distributed in fruits, vegetables, and other plants. It exhibits a plethora of bioactive properties, such as antioxidant, anticancer, and anti-inflammatory and neuroprotective activities, making it an extremely promising phytochemical. Rutin has shown great potential in the treatment of a wide variety of metabolic diseases and received considerable attention in recent years. Fortuitously, various research studies have validated rutin's extensive biological functions in treating metabolic disorders. Despite the fact that the exact pathophysiological mechanisms through which rutin has a hepatoprotective effect on MAFLD are still not fully elucidated. This review comprehensively outlines rutin's multifaceted preventive and therapeutic effects in MAFLD, including the modulation of lipid metabolism, reduction of insulin resistance, diminution of inflammation and oxidative stress, combatting of obesity, and influence on intestinal flora. This paper details the known molecular targets and pathways of rutin in MAFLD pathogenesis. It endeavored to provide new ideas for treating MAFLD and accelerating its translation from bench to bedside.
C1 [Wang, Qianzhuo; Lu, Ruiling] Zhejiang Chinese Med Univ, Sch Clin Med 4, Hangzhou 310053, Zhejiang, Peoples R China.
   [Zhang, Yingjuan; Zhao, Qingwen; Gao, Yue] Westlake Univ, Affiliated Hangzhou Peoples Hosp 1, Sch Med, Zhejiang Key Lab Tradit Chinese Med Prevent & Trea, Hangzhou 310006, Zhejiang, Peoples R China.
C3 Zhejiang Chinese Medical University; Westlake University
RP Zhao, QW; Gao, Y (corresponding author), Westlake Univ, Affiliated Hangzhou Peoples Hosp 1, Sch Med, Zhejiang Key Lab Tradit Chinese Med Prevent & Trea, Hangzhou 310006, Zhejiang, Peoples R China.
EM 17111010048@fudan.edu.cn; gaoyue@hospital.westlake.edu.cn
FU Zhejiang Provincial Natural Science Foundation of China [LQ23C070004];
   Construction fund of medical key disciplines of Hangzhou [OO20200055];
   Zhejiang Traditional Chinese Medicine Administration Foundation of China
   [2024ZF111]
FX This work was supported by grants from Zhejiang Provincial Natural
   Science Foundation of China (LQ23C070004 to Q.Z) , Zhejiang Traditional
   Chinese Medicine Administration Foundation of China (2024ZF111 to Q.Z.)
   , and the construction fund of medical key disci-plines of Hangzhou
   (OO20200055 to Y.G) .
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NR 103
TC 6
Z9 6
U1 5
U2 8
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0367-326X
EI 1873-6971
J9 FITOTERAPIA
JI Fitoterapia
PD OCT
PY 2024
VL 178
AR 106178
DI 10.1016/j.fitote.2024.106178
EA AUG 2024
PG 10
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA D9Y5X
UT WOS:001299665400001
PM 39153555
DA 2025-06-11
ER

PT J
AU Liang, LZ
   Meng, ZH
   Zhang, F
   Jianguo, Z
   Fang, SG
   Hu, QA
   Tang, XA
   Li, YA
AF Liang, Lizhen
   Meng, Zihui
   Zhang, Fei
   Jianguo, Zhu
   Fang, Shuguang
   Hu, Qingang
   Tang, Xuna
   Li, Yanan
TI Lactobacillus gasseri LG08 and Leuconostoc mesenteroides
   LM58 exert preventive effect on the development of hyperuricemia by
   repairing antioxidant system and intestinal flora balance
SO FRONTIERS IN MICROBIOLOGY
LA English
DT Article
DE hyperuricemia; probiotic; prevention; therapy; antioxidant system
ID METABOLIC SYNDROME; OXIDATIVE STRESS; XANTHINE-OXIDASE; URIC-ACID;
   LACTIS
AB IntroductionCurrently, hyperuricemia has shown a surprisingly rising trend, which attracts widespread attention due to potentially major health risks. Considering the inevitable side effects of long-term medicine, probiotics are emerging as potential therapeutics due to their ability to improve uric acid metabolism and superior safety. MethodsIn our study, two strains of probiotics, Lactobacillus gasseri LG08 (LG08) and Leuconostoc mesenteroides LM58 (LM58) isolated from kimchi were evaluated for the prebiotic properties in vitro and uric-lowering effects in vivo. Here, hyperuricemia animal model and 16S rRNA gene amplicons analysis were further studied to investigate whether these probiotics exert different effects in prevention and treatment. ResultsIn vivo indicators and intestinal flora immunity revealed that both LG08 and LM58 significantly prevent the development and progression of hyperuricemia, repair the antioxidant system and maintain intestinal flora balance in healthy rats, especially LM58. After hyperuricemia was formed, although the effect of LG08 and LM58 could decrease the level of uric acid, the effect to reverse and repair antioxidant levels in the body was limited. DiscussionIn our study, these findings have important implications for hyperuricemia prevention and therapy, and provided more mechanistic insights into the effect of probiotics in hyperuricemia.
C1 [Liang, Lizhen; Meng, Zihui; Li, Yanan] Nanjing Normal Univ, Sch Food Sci & Pharmaceut Engn, Nanjing, Peoples R China.
   [Zhang, Fei; Hu, Qingang; Tang, Xuna] Nanjing Univ, Nanjing Stomatol Hosp, Affiliated Hosp Med Sch, Nanjing, Peoples R China.
   [Jianguo, Zhu; Fang, Shuguang] Wecare Bio Probiot Co Ltd, Dept Res & Dev, Suzhou, Peoples R China.
C3 Nanjing Normal University; Nanjing University
RP Li, YA (corresponding author), Nanjing Normal Univ, Sch Food Sci & Pharmaceut Engn, Nanjing, Peoples R China.; Hu, QA; Tang, XA (corresponding author), Nanjing Univ, Nanjing Stomatol Hosp, Affiliated Hosp Med Sch, Nanjing, Peoples R China.; Jianguo, Z (corresponding author), Wecare Bio Probiot Co Ltd, Dept Res & Dev, Suzhou, Peoples R China.
EM liyanan@njnu.edu.cn
RI Tang, xuna/KWU-1692-2024; Acuna, Daniel/JJF-1452-2023
OI Tang, Xuna/0000-0001-7819-7198
FU National Natural Science Foundation of China [82203031]; Basic Research
   Program of Jiangsu Province; Natural Science Research of Jiangsu Higher
   Education Institutions of China [BK20220375, 22KIB350007]; Jiangsu
   Traditional Chinese Medicine Science and Technology Development
   [MS2022051]; Nanjing Medical Science and Technique Development
   Foundation [YKK21185]
FX & nbsp;This study was funded by the National Natural Science Foundation
   of China under award number 82203031. This work was also funded by the
   Basic Research Program of Jiangsu Province and Natural Science Research
   of Jiangsu Higher Education Institutions of China for financial support
   through the award numbers BK20220375 and 22KIB350007. Additionally, this
   study was funded by Jiangsu Traditional Chinese Medicine Science and
   Technology Development under award number MS2022051 and Nanjing Medical
   Science and Technique Development Foundation under award number
   YKK21185.
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NR 38
TC 12
Z9 12
U1 12
U2 117
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1664-302X
J9 FRONT MICROBIOL
JI Front. Microbiol.
PD JUN 12
PY 2023
VL 14
AR 1211831
DI 10.3389/fmicb.2023.1211831
PG 14
WC Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Microbiology
GA K4JE6
UT WOS:001016109300001
PM 37378287
OA Green Accepted, gold
DA 2025-06-11
ER

PT J
AU Mohan, V
   Sudha, V
   Shobana, S
   Gayathri, R
   Krishnaswamy, K
AF Mohan, Viswanathan
   Sudha, Vasudevan
   Shobana, Shanmugam
   Gayathri, Rajagopal
   Krishnaswamy, Kamala
TI Are Unhealthy Diets Contributing to the Rapid Rise of Type 2 Diabetes in
   India?
SO JOURNAL OF NUTRITION
LA English
DT Review
DE South East Asians; Asian Indians; India; type 2 diabetes; obesity; high
   carbohydrate diets; white rice; glycemic index; glycemic load; nutrition
   transition
ID URBAN-RURAL EPIDEMIOLOGY; ASIAN INDIANS; METABOLIC SYNDROME; OXIDATIVE
   STRESS; GLYCEMIC INDEX; SOUTH ASIANS; ICMR-INDIAB; WHITE RICE; BROWN
   RICE; NUTRITION
AB The prevalence of diabetes is increasing at an alarming rate globally, particularly in India. In the urban areas, the prevalence of diabetes among adults aged >= 20 y, which was around 2% in the early 1970's, has increased by >20% in 50 y. The rapid nutrition transition due to high economic growth rates increased urbanization and globalization has resulted in higher intakes of processed refined grain staples, mainly white rice in Southern and Eastern India and refined wheat in Northern and Western India. This coupled with inadequate quantity and quality of protein; unhealthy fats; lower intake of vegetables, fruits, and fiber; and a sedentary lifestyle are the main drivers of the diabetes epidemic in India. This review attempts to discuss both the quality and quantity of Indian diets with specific reference to mac-ronutrients. This review also outlines some of the strategies that can be employed to slow down the diabetes epidemic in this region. We believe that the lessons learned from India would be applicable to other developing nations as well, particularly to the South East Asian region.
C1 [Mohan, Viswanathan] Madras Diabet Res Fdn, Dr Mohans Diabet Specialties Ctr, IDF Ctr Diabet Educ, Dept Diabetol, Chennai, Tamil Nadu, India.
   [Sudha, Vasudevan; Gayathri, Rajagopal; Krishnaswamy, Kamala] Madras Diabet Res Fdn, Dept Foods Nutr & Dietet Res, Chennai, Tamil Nadu, India.
   [Shobana, Shanmugam] Madras Diabet Res Fdn, Dept Diabet Food Technol, Chennai, Tamil Nadu, India.
C3 Madras Diabetes Research Foundation; Madras Diabetes Research
   Foundation; Madras Diabetes Research Foundation
RP Mohan, V (corresponding author), Madras Diabet Res Fdn, Dr Mohans Diabet Specialties Ctr, IDF Ctr Diabet Educ, Dept Diabetol, Chennai, Tamil Nadu, India.
EM drmohans@diabetes.ind.in
RI Viswanathan, Mohan/C-2321-2009
OI Mohan, Viswanathan/0000-0001-5038-6210
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NR 78
TC 12
Z9 12
U1 1
U2 10
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0022-3166
EI 1541-6100
J9 J NUTR
JI J. Nutr.
PD APR
PY 2023
VL 153
IS 4
BP 940
EP 948
DI 10.1016/j.tjnut.2023.02.028
EA APR 2023
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA F6NQ1
UT WOS:000983496300001
PM 36858259
OA Bronze
DA 2025-06-11
ER

PT J
AU Reid, AL
   Alexander, MS
AF Reid, Andrea L.
   Alexander, Matthew S.
TI The Interplay of Mitophagy and Inflammation in Duchenne Muscular
   Dystrophy
SO LIFE-BASEL
LA English
DT Review
DE mitophagy; DMD; inflammation; dystrophin; dystrophy
ID NF-KAPPA-B; SKELETAL-MUSCLE; MDX MOUSE; DIAPHRAGM MUSCLE; OXIDATIVE
   STRESS; P65 SUBUNIT; EARLY-ONSET; RESVERATROL; ACTIVATION; PGC-1-ALPHA
AB Duchenne muscular dystrophy (DMD) is an X-linked neuromuscular disease caused by a pathogenic disruption of the DYSTROPHIN gene that results in non-functional dystrophin protein. DMD patients experience loss of ambulation, cardiac arrhythmia, metabolic syndrome, and respiratory failure. At the molecular level, the lack of dystrophin in the muscle results in myofiber death, fibrotic infiltration, and mitochondrial dysfunction. There is no cure for DMD, although dystrophin-replacement gene therapies and exon-skipping approaches are being pursued in clinical trials. Mitochondrial dysfunction is one of the first cellular changes seen in DMD myofibers, occurring prior to muscle disease onset and progresses with disease severity. This is seen by reduced mitochondrial function, abnormal mitochondrial morphology and impaired mitophagy (degradation of damaged mitochondria). Dysfunctional mitochondria release high levels of reactive oxygen species (ROS), which can activate pro-inflammatory pathways such as IL-1 beta and IL-6. Impaired mitophagy in DMD results in increased inflammation and further aggravates disease pathology, evidenced by increased muscle damage and increased fibrosis. This review will focus on the critical interplay between mitophagy and inflammation in Duchenne muscular dystrophy as a pathological mechanism, as well as describe both candidate and established therapeutic targets that regulate these pathways.
C1 [Reid, Andrea L.; Alexander, Matthew S.] Univ Alabama Birmingham, Div Neurol Childrens Alabama, Dept Pediat, Birmingham, AL 35294 USA.
   [Alexander, Matthew S.] Univ Alabama Birmingham, UAB Ctr Exercise Med UCEM, Birmingham, AL 35205 USA.
   [Alexander, Matthew S.] Univ Alabama Birmingham, Dept Genet, Birmingham, AL 35294 USA.
   [Alexander, Matthew S.] Univ Alabama Birmingham, UAB Civitan Int Res Ctr CIRC, Birmingham, AL 35233 USA.
C3 University of Alabama System; University of Alabama Birmingham;
   University of Alabama System; University of Alabama Birmingham;
   University of Alabama System; University of Alabama Birmingham;
   University of Alabama System; University of Alabama Birmingham
RP Alexander, MS (corresponding author), Univ Alabama Birmingham, Div Neurol Childrens Alabama, Dept Pediat, Birmingham, AL 35294 USA.; Alexander, MS (corresponding author), Univ Alabama Birmingham, UAB Ctr Exercise Med UCEM, Birmingham, AL 35205 USA.; Alexander, MS (corresponding author), Univ Alabama Birmingham, Dept Genet, Birmingham, AL 35294 USA.; Alexander, MS (corresponding author), Univ Alabama Birmingham, UAB Civitan Int Res Ctr CIRC, Birmingham, AL 35233 USA.
EM areid01@uab.edu; malexander@peds.uab.edu
OI Alexander, Matthew/0000-0001-7406-5171
FU Eunice Kennedy Shriver National Institute of Child Health and Human
   Development, NIH; National Institutes of Health [R01HD095897]; Muscular
   Dystrophy Association (MDA) [MDA418254]; NIH NIAMS [R21AR074006]
FX This research was funded by the Eunice Kennedy Shriver National
   Institute of Child Health and Human Development, NIH, HHS of the
   National Institutes of Health under award number R01HD095897 awarded to
   M.S.A. M.S.A. is also a co-investigator on an NIH NIAMS award
   R21AR074006 and is funded by a Muscular Dystrophy Association (MDA)
   grant (MDA418254).
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NR 91
TC 29
Z9 33
U1 0
U2 13
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2075-1729
J9 LIFE-BASEL
JI Life-Basel
PD JUL
PY 2021
VL 11
IS 7
AR 648
DI 10.3390/life11070648
PG 11
WC Biology; Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics; Microbiology
GA TP1EY
UT WOS:000677342600001
PM 34357020
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Antonucci, L
   Porcu, C
   Iannucci, G
   Balsano, C
   Barbaro, B
AF Antonucci, Laura
   Porcu, Cristiana
   Iannucci, Gino
   Balsano, Clara
   Barbaro, Barbara
TI Non-Alcoholic Fatty Liver Disease and Nutritional Implications: Special
   Focus on Copper
SO NUTRIENTS
LA English
DT Review
DE NAFLD; copper; ROS; nutrients; antioxidants; lipids; liver
ID MITOCHONDRIAL RESPIRATORY-CHAIN; HEPATIC STEATOSIS; INSULIN-RESISTANCE;
   METABOLIC SYNDROME; CARDIOVASCULAR-DISEASE; DIABETES-MELLITUS;
   STEATOHEPATITIS; MICE; DIET; IONS
AB Non-alcoholic fatty liver disease (NAFLD) is characterized by excess lipids in hepatocytes, due to excessive fatty acid influx from adipose tissue, de novo hepatic lipogenesis, in addition to excessive dietary fat and carbohydrate intake. Chronic hepatic lipid overload induces mitochondrial oxidative stress and cellular damage leading the development of NAFLD into a more severe liver disease condition, non-alcoholic steato-hepatitis (NASH). In turn, this can progress to cirrhosis and hepatocellular carcinoma (HCC). Among others, copper is one of the main bio-metals required for the preponderance of the enzymes involved in physiological redox reactions, which primarily occurs during mitochondrial respiration. Thus, copper homeostasis could be considered a target point for counteracting the progression of NAFLD. Accordingly, many diseases are correlated to unbalanced copper levels and, actually, some clinical trials are examining the use of copper chelating agents. Currently, no pharmacological interventions are approved for NAFLD, but nutritional and lifestyle modifications are always recommended. Fittingly, antioxidant food agents recognized to improve NAFLD and its complications have been described in the literature to bind copper. Therefore, this review describes the role of nutrition in the development and progression of NAFLD with a particular focus on copper and copper-binding antioxidant compounds against NAFLD.
C1 [Antonucci, Laura; Porcu, Cristiana; Balsano, Clara; Barbaro, Barbara] Francesco Balsano Fdn, I-00185 Rome, Italy.
   [Iannucci, Gino] Sapienza Univ Roma, Dipartimento Med Interna & Specialita Med, I-00185 Rome, Italy.
C3 Sapienza University Rome
RP Barbaro, B (corresponding author), Francesco Balsano Fdn, I-00185 Rome, Italy.
EM antonuccilaura1986@libero.it; cristiana.porcu@live.it;
   gino.iannucci@uniroma1.it; clara.balsano@cc.univaq.it;
   bbarbaro71@yahoo.it
RI Antonucci, Laura/AAA-5022-2020; Iannucci, Gino/W-9210-2019; Balsano,
   Clara/MCY-5404-2025; Barbaro, Barbara/K-5588-2016
OI Antonucci, Laura/0000-0001-8965-2432; Balsano,
   Clara/0000-0002-9615-7031; Barbaro, Barbara/0000-0002-2208-5370;
   IANNUCCI, GINO/0000-0003-3055-965X; Porcu, Cristiana/0000-0001-7415-7615
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NR 71
TC 59
Z9 68
U1 3
U2 15
PU MDPI AG
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 2072-6643
J9 NUTRIENTS
JI Nutrients
PD OCT
PY 2017
VL 9
IS 10
AR 1137
DI 10.3390/nu9101137
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA FM0DM
UT WOS:000414629900093
PM 29057834
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Zhang, XL
   Yao, J
   Gao, K
   Chi, Y
   Mitsui, T
   Ihara, T
   Sawada, N
   Kamiyama, M
   Fan, JL
   Takeda, M
AF Zhang, Xiling
   Yao, Jian
   Gao, Kun
   Chi, Yuan
   Mitsui, Takahiko
   Ihara, Tatsuya
   Sawada, Norifumi
   Kamiyama, Manabu
   Fan, Jianglin
   Takeda, Masayuki
TI AMPK Suppresses Connexin43 Expression in the Bladder and Ameliorates
   Voiding Dysfunction in Cyclophosphamide-induced Mouse Cystitis
SO SCIENTIFIC REPORTS
LA English
DT Article
ID JUNCTIONAL INTERCELLULAR COMMUNICATION; ACTIVATED PROTEIN-KINASE; CREB
   COACTIVATOR TORC2; REACTIVE OXYGEN; DETRUSOR OVERACTIVITY; OUTLET
   OBSTRUCTION; METABOLIC SYNDROME; CELL CONTRACTION; OXIDATIVE STRESS;
   UP-REGULATION
AB Bladder voiding dysfunction is closely related to local oxidation, inflammation, and enhanced channel activities. Given that the AMP-activated protein kinase (AMPK) has anti-oxidative, anti-inflammatory and channel-inhibiting properties, we examined whether and how AMPK affected bladder activity. AMPK activation in rat bladder smooth muscle cells (BSMCs) using three different AMPK agonists resulted in a decrease in connexin43 (Cx43) expression and function, which was associated with reduced CREB phosphorylation, Cx43 promoter activity and mRNA expression, but not Cx43 degradation. Downregulation of CREB with siRNA increased Cx43 expression. A functional analysis revealed that AMPK weakened BSMC contraction and bladder capacity. AMPK also counteracted the IL-1 beta- and TNF alpha-induced increase in Cx43 in BSMCs. In vivo administration of the AMPK agonist AICAR attenuated cyclophosphamide-initiated bladder oxidation, inflammation, Cx43 expression and voiding dysfunction. Further analysis comparing the responses of the wild-type (Cx43(+/+)) and heterozygous (Cx43(+/-)) Cx43 mice to cyclophosphamide revealed that the Cx43(+/-) mice retained a relatively normal micturition pattern compared to the Cx43(+/+) mice. Taken together, our results indicate that AMPK inhibits Cx43 in BSMCs and improves bladder activity under pathological conditions. We propose that strategies that target AMPK can be developed as novel therapeutic approaches for treating bladder dysfunction.
C1 [Zhang, Xiling; Yao, Jian; Gao, Kun; Chi, Yuan] Univ Yamanashi, Interdisciplinary Grad Sch Med & Engn, Dept Mol Signaling, Kofu, Yamanashi, Japan.
   [Mitsui, Takahiko; Ihara, Tatsuya; Sawada, Norifumi; Kamiyama, Manabu; Takeda, Masayuki] Univ Yamanashi, Interdisciplinary Grad Sch Med & Engn, Dept Urol, Kofu, Yamanashi, Japan.
   [Fan, Jianglin] Univ Yamanashi, Interdisciplinary Grad Sch Med & Engn, Dept Mol Pathol, Kofu, Yamanashi, Japan.
   [Zhang, Xiling] China Med Univ, Affiliated Hosp 4, Dept Urol, Shenyang 110001, Peoples R China.
C3 University of Yamanashi; University of Yamanashi; University of
   Yamanashi; China Medical University
RP Yao, J (corresponding author), Univ Yamanashi, Interdisciplinary Grad Sch Med & Engn, Dept Mol Signaling, Kofu, Yamanashi, Japan.; Takeda, M (corresponding author), Univ Yamanashi, Interdisciplinary Grad Sch Med & Engn, Dept Urol, Kofu, Yamanashi, Japan.
EM yao@yamanashi.ac.jp; matakeda@yamanashi.ac.jp
RI Takeda, Masayuki/J-6457-2019; , Takahiko/H-6660-2019; Liu,
   Simin/I-3689-2014
OI Fan, Jianglin/0000-0002-1737-6130; Yao, Jian/0000-0003-2622-0215
FU Ministry of Education, Culture, Sports, Science and Technology, Japan
   [26461219, 26462438]; Grants-in-Aid for Scientific Research [25670190,
   15H04718, 15H04972] Funding Source: KAKEN
FX This work was supported by a grant from the Ministry of Education,
   Culture, Sports, Science and Technology, Japan (26461219 to J.Y. and
   26462438 to K.M. and J.Y.). We thank Dr. Fumiko Obata (Department of
   Molecular Pathology, University of Yamanashi) for her help in
   histochemistry study.
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NR 61
TC 27
Z9 29
U1 0
U2 7
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD JAN 25
PY 2016
VL 6
AR 19708
DI 10.1038/srep19708
PG 16
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA DB9CI
UT WOS:000368813300002
PM 26806558
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Wirix, AJG
   Kaspers, PJ
   Nauta, J
   Chinapaw, MJM
   Kist-van Holthe, JE
AF Wirix, A. J. G.
   Kaspers, P. J.
   Nauta, J.
   Chinapaw, M. J. M.
   Kist-van Holthe, J. E.
TI Pathophysiology of hypertension in obese children: a systematic review
SO OBESITY REVIEWS
LA English
DT Review
DE Children; hypertension; obesity; pathophysiology
ID CARDIOVASCULAR RISK-FACTORS; AMBULATORY BLOOD-PRESSURE;
   BETA(3)-ADRENERGIC RECEPTOR GENE; INTIMA-MEDIA THICKNESS; SERUM
   URIC-ACID; BODY-MASS INDEX; METABOLIC SYNDROME; CHILDHOOD OBESITY;
   CHINESE CHILDREN; YOUNG-ADULTS
AB Hypertension is increasingly common in overweight and obese children. The mechanisms behind the development of hypertension in obesity are complex, and evidence is limited. In order to effectively treat obese children for hypertension, it is important to have a deeper understanding of the pathophysiology of hypertension in obese children. The present review summarizes the main factors associated with hypertension in obese children and discusses their potential role in its pathophysiology. Systematic searches were conducted in PubMed and EMBASE for articles published up to October 2014. In total, 60 relevant studies were included. The methodological quality of the included studies ranged from weak to strong. Several factors important in the development of hypertension in obese children have been suggested, including endocrine determinants, such as corticosteroids and adipokines, sympathetic nervous system activity, disturbed sodium homeostasis, as well as oxidative stress, inflammation and endothelial dysfunction. Understanding the pathophysiology of hypertension in overweight and obese children is important and could have implications for its screening and treatment. Based on solely cross-sectional observational studies, it is impossible to infer causality. Longitudinal studies of high methodological quality are needed to gain more insight into the complex mechanisms behind the development of hypertension in obese children.
C1 [Wirix, A. J. G.; Chinapaw, M. J. M.; Kist-van Holthe, J. E.] Vrije Univ Amsterdam Med Ctr, EMGO Inst Hlth & Care Res, Dept Publ & Occupat Hlth, Amsterdam, Netherlands.
   [Kaspers, P. J.] Vrije Univ Amsterdam Med Ctr, Med Lib, Amsterdam, Netherlands.
   [Nauta, J.] Erasmus MC, Dept Pediat Nephrol, Rotterdam, Netherlands.
C3 Vrije Universiteit Amsterdam; VU UNIVERSITY MEDICAL CENTER; Vrije
   Universiteit Amsterdam; VU UNIVERSITY MEDICAL CENTER; Erasmus University
   Rotterdam; Erasmus MC
RP Wirix, AJG (corresponding author), van der Boechorststr 7, NL-1081 BT Amsterdam, Netherlands.
EM a.wirix@vumc.nl
RI Chin A Paw, Mai/N-1665-2019
OI Kaspers, Pam/0000-0002-8696-1130; Chin A Paw, Mai/0000-0001-6259-2441
FU Dutch Kidney Foundation [VR12.03]
FX This research was funded by a grant (VR12.03) from the Dutch Kidney
   Foundation.
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NR 85
TC 49
Z9 50
U1 0
U2 23
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1467-7881
EI 1467-789X
J9 OBES REV
JI Obes. Rev.
PD OCT
PY 2015
VL 16
IS 10
BP 831
EP 842
DI 10.1111/obr.12305
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA CU3KO
UT WOS:000363424100002
PM 26098701
DA 2025-06-11
ER

PT J
AU Rosei, CA
   Withers, SB
   Belcaid, L
   De Ciuceis, C
   Rizzoni, D
   Heagerty, AM
AF Rosei, Claudia Agabiti
   Withers, Sarah B.
   Belcaid, Laila
   De Ciuceis, Carolina
   Rizzoni, Damiano
   Heagerty, Anthony M.
TI Blockade of the renin-angiotensin system in small arteries and
   anticontractile function of perivascular adipose tissue
SO JOURNAL OF HYPERTENSION
LA English
DT Article
DE hypoxia; microcirculation; obesity; small arteries; Wistar-Kyoto rats
ID SUBCUTANEOUS SMALL ARTERIES; SMOOTH-MUSCLE-CELLS; METABOLIC SYNDROME;
   RESISTANCE VESSELS; OBESE-PATIENTS; ESSENTIAL HYPERTENSIVES; VASCULAR
   FUNCTION; HYPOXIA; INFLAMMATION; EXPRESSION
AB Background/aims: In patients with obesity, there is increased inflammation with attendant oxidative stress in perivascular adipose tissue. This has functional consequences with loss of vasodilator adipokine bioavailability. Part of the inflammatory response is mediated by increased activation of the renin-angiotensin-aldosterone axis. Therefore, this study was designed to investigate whether angiotensin-converting enzyme inhibitors or angiotensin receptor blockers can improve the anticontractile function of perivascular adipose tissue.
   Methods: Segments of rat mesenteric small artery were dissected and mounted in a wire myograph and contracted to incremental doses of norepinephrine in the presence and absence of perivascular adipose tissue and in conditions of normal oxygenation or after hypoxia and incubated with captopril or telmisartan.
   Results: Vessels with perivascular adipose tissue contracted significantly less than arteries with perivascular adipose tissue removed under normal oxygenation conditions, indicating that perivascular adipose tissue exerts an anticontractile effect. Hypoxia induced a loss of this anticontractile effect which could be completely prevented with captopril or telmisartan.
   Conclusion: The in-vitro creation of a hypoxic environment can simulate the loss of anticontractile perivascular adipose tissue function seen in vivo in obese patients, and this can be prevented using inhibitors of the renin-angiotensin cascade.
C1 [Withers, Sarah B.; Belcaid, Laila; Heagerty, Anthony M.] Univ Manchester, Fac Med & Human Sci, Inst Cardiovasc Sci, Manchester M13 9PL, Lancs, England.
   [Rosei, Claudia Agabiti; De Ciuceis, Carolina; Rizzoni, Damiano] Univ Brescia, Dept Clin & Expt Sci, Med Clin, Brescia, Italy.
C3 University of Manchester; University of Brescia
RP Rosei, CA (corresponding author), Dept Clin & Expt Sci, Med Clin, 2a Med Spedali Civili Brescia, I-25100 Brescia, Italy.
EM claudiaagabitirosei@libero.it
RI Rizzoni, Damiano/E-9967-2010; De Ciuceis, Carolina/AAC-6678-2022
OI Withers, Sarah/0000-0002-7021-881X; Heagerty,
   Anthony/0000-0002-9043-2119; Agabiti Rosei, Claudia/0000-0002-9664-2408;
   Belcaid, Laila/0000-0001-8062-1533
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NR 49
TC 25
Z9 25
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0263-6352
EI 1473-5598
J9 J HYPERTENS
JI J. Hypertens.
PD MAY
PY 2015
VL 33
IS 5
BP 1039
EP 1045
DI 10.1097/HJH.0000000000000506
PG 7
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA CF8FG
UT WOS:000352790900021
PM 25909701
DA 2025-06-11
ER

PT J
AU Morishita, R
   Nakagami, H
AF Morishita, Ryuichi
   Nakagami, Hironori
TI Teneligliptin: expectations for its pleiotropic action
SO EXPERT OPINION ON PHARMACOTHERAPY
LA English
DT Review
DE diabetes mellitus; dipeptidyl peptidase-4 inhibitors; glucose
   fluctuations; glycemic control; teneligliptin; vascular function
ID DIPEPTIDYL PEPTIDASE-4 INHIBITOR; TYPE-2 DIABETES-MELLITUS; JAPANESE
   PATIENTS; IV INHIBITOR; GLUCOSE FLUCTUATIONS; ENDOTHELIAL-CELLS;
   OXIDATIVE STRESS; DOUBLE-BLIND; SAFETY; EFFICACY
AB Introduction: The main aim in the management of diabetes mellitus is to prevent the development of its complications. Large fluctuations in glucose levels may increase the risk of complications, so improved control of glucose fluctuations, in addition to management of chronic hyperglycemia, could represent an important goal in diabetes pharmacotherapy.
   Areas covered: Pre-clinical and clinical studies suggest that poor control of blood glucose fluctuations contributes to progression of diabetic vascular complications. Dipeptidyl peptidase (DPP)-4 inhibitors are one of several drug classes used to manage diabetes, and the potential vasoprotective effects of DPP-4 inhibition have attracted attention in recent years. The DPP-4 inhibitor teneligliptin was approved in Japan in 2012 and in Korea in 2014. Teneligliptin differs in its structural and pharmacokinetic characteristics compared with other drugs in the same class. It appears to have potent, sustained effects on glycemic control, thereby reducing the complications of hypoglycemia and postprandial hyperglycemia. Because of its effects on vascular function, teneligliptin may be beneficial in patients at high risk of cardiovascular disease.
   Expert opinion: The possible pleiotropic effects of teneligliptin, such as those on endothelial function and metabolic syndrome, are of great interest. This review examines these effects and their potential clinical relevance.
C1 [Morishita, Ryuichi; Nakagami, Hironori] Osaka Univ, Sch Med, Dept Clin Gene Therapy, Suita, Osaka 5650871, Japan.
C3 The University of Osaka
RP Morishita, R (corresponding author), Osaka Univ, Sch Med, Dept Clin Gene Therapy, 2-2 Yamada Oka, Suita, Osaka 5650871, Japan.
EM morishit@cgt.med.osaka-u.ac.jp
RI Nakagami, Hironori/GLU-0570-2022
OI Nakagami, Hironori/0000-0003-4494-3601
FU Mitsubishi Tanabe Pharma Corp.; AnGes MG, Inc.; Novartis; Shionogi;
   Boehringer Ingelheim; Rohto; Bayer
FX The Department of Clinical Gene Therapy is financially supported by
   Mitsubishi Tanabe Pharma Corp., AnGes MG, Inc., Novartis, Shionogi,
   Boehringer Ingelheim and Rohto. The Division of Vascular Medicine and
   Epigenetics (to which Hironori Nakagami belongs) is financially
   supported by Bayer. Ryuichi Morishita is a founder of AnGes MG, Inc.,
   and holds stock in the company. Editorial support for the preparation of
   this manuscript was provided by H Roberton. Publication support was
   funded by Mitsubishi Tanabe Pharma Corp. The authors have no other
   relevant affiliations or financial involvement with any organization or
   entity with a financial interest in or financial conflict with the
   subject matter or materials discussed in the manuscript apart from those
   disclosed.
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NR 39
TC 33
Z9 33
U1 0
U2 8
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1465-6566
EI 1744-7666
J9 EXPERT OPIN PHARMACO
JI Expert Opin. Pharmacother.
PD FEB
PY 2015
VL 16
IS 3
BP 417
EP 426
DI 10.1517/14656566.2015.1000301
PG 10
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA AZ3SO
UT WOS:000348147200015
PM 25597385
OA Bronze
DA 2025-06-11
ER

PT J
AU Pisonero-Vaquero, S
   González-Gallego, J
   Sánchez-Campos, S
   García-Mediavilla, MV
AF Pisonero-Vaquero, Sandra
   Gonzalez-Gallego, Javier
   Sanchez-Campos, Sonia
   Victoria Garcia-Mediavilla, Maria
TI Flavonoids and Related Compounds in Non-Alcoholic Fatty Liver Disease
   Therapy
SO CURRENT MEDICINAL CHEMISTRY
LA English
DT Article
DE Antioxidant; flavonoids; insulin resistance; lipid accumulation; NAFLD;
   quercetin
ID INDUCED HEPATIC STEATOSIS; TRIGLYCERIDE TRANSFER PROTEIN; IMPROVES
   INSULIN-RESISTANCE; ACTIVATED RECEPTOR-GAMMA; NITRIC-OXIDE SYNTHASE;
   KAPPA-B ACTIVATION; LIPID-ACCUMULATION; OXIDATIVE STRESS; GREEN TEA;
   MITOCHONDRIAL DYSFUNCTION
AB Non-alcoholic fatty liver disease (NAFLD), the hepatic manifestation of metabolic syndrome, is one of the most common chronic liver diseases, which may progress to fibrosis, cirrhosis and hepatocellular carcinoma. NAFLD is characterized by the accumulation of lipids in the liver arising from multiple factors: increased fatty acid uptake, increased de novo lipogenesis, reduced fatty acid oxidation and very low density lipoproteins (VLDL) secretion. Most therapeutic approaches for this disease are often directed at reducing body mass index and improving insulin resistance through lifestyle modifications, bariatric surgery and pharmacological treatments. Nevertheless, there is increasing evidence that the use of natural compounds, as polyphenols, exert multiple benefits on the disorders associated with NAFLD. These molecules seem to be able to regulate the expression of genes mainly involved in de novo lipogenesis and fatty acid oxidation, which contributes to their lipid-lowering effect in the liver. Their antioxidant, anti-inflammatory, antifibrogenic and antilipogenic properties seem to confer on them a great potential as strategy for preventing NAFLD progression. In this review, we summarized the effects of these compounds, especially flavonoids, and their mechanisms of action, that have been reported in several studies carried out in in vitro and in vivo models of NAFLD.
C1 [Pisonero-Vaquero, Sandra; Gonzalez-Gallego, Javier; Sanchez-Campos, Sonia; Victoria Garcia-Mediavilla, Maria] Univ Leon, Inst Biomed IBIOMED, E-24071 Leon, Spain.
   [Gonzalez-Gallego, Javier; Sanchez-Campos, Sonia; Victoria Garcia-Mediavilla, Maria] Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Hepat & Digest, Madrid, Spain.
C3 Universidad de Leon; CIBER - Centro de Investigacion Biomedica en Red;
   CIBEREHD; Instituto de Salud Carlos III
RP García-Mediavilla, MV (corresponding author), Inst Biomed IBIOMED, Campus Univ, Leon 24071, Spain.
EM mvgarm@unileon.es
RI Gonzalez-Gallego, Javier/D-8219-2012; Garcia-Mediavilla,
   Victoria/F-9641-2015; Sanchez-Campos, Sonia/F-9654-2015
OI Garcia-Mediavilla, Victoria/0000-0002-5722-7500; Gonzalez-Gallego,
   Javier/0000-0002-4386-9342; Sanchez-Campos, Sonia/0000-0003-2672-734X
FU Ministerio de Economia y Competitividad/FEDER [BFU2013-48141-R]; Junta
   de Castilla y Leon [LE135U13, GRS1000/A/14]; CIBERehd contract;
   Instituto de Salud Carlos III, Spain
FX This work was supported by grants to Javier Gonzalez-Gallego and Sonia
   Sanchez-Campos from Ministerio de Economia y Competitividad/FEDER
   (BFU2013-48141-R) and from Junta de Castilla y Leon (LE135U13 and
   GRS1000/A/14). Maria Victoria Garcia-Mediavilla was supported by
   CIBERehd contract. CIBERehd is funded by the Instituto de Salud Carlos
   III, Spain.
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NR 139
TC 44
Z9 46
U1 3
U2 35
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 0929-8673
EI 1875-533X
J9 CURR MED CHEM
JI Curr. Med. Chem.
PY 2015
VL 22
IS 25
BP 2991
EP 3012
DI 10.2174/0929867322666150805094940
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WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Pharmacology &
   Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
GA CQ1RD
UT WOS:000360375400006
PM 26242257
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Gruber, HE
   Watts, JA
   Riley, FE
   Fulkerson, MB
   Norton, HJ
   Hanley, EN
AF Gruber, Helen E.
   Watts, John A.
   Riley, Frank E.
   Fulkerson, Mary-Beth
   Norton, H. James
   Hanley, Edward N., Jr.
TI Mitochondrial bioenergetics, mass, and morphology are altered in cells
   of the degenerating human annulus
SO JOURNAL OF ORTHOPAEDIC RESEARCH
LA English
DT Article
DE bioenergetics; disc degeneration; annulus; mitochondrial respiration
ID HUMAN INTERVERTEBRAL DISC; 3-DIMENSIONAL CULTURE; TARGETED ANTIOXIDANT;
   METABOLIC SYNDROME; GENE-EXPRESSION; IN-VIVO; DYSFUNCTION; APOPTOSIS;
   PATHWAYS; DISEASE
AB Back pain and intervertebral disc degeneration have a growing socioeconomic healthcare impact. Information on mitochondrial function in human intervertebral disc cells, however, is surprisingly sparse. We assessed mitochondrial bioenergetics, mass, and ultrastructure in annulus cells cultured from human discs of varying degenerative stages. Citrate synthase activity (reflecting mitochondrial mass) declined significantly with increasing Thompson grade (p<0.0001). Both mitochondrial (p=0.009) and non-mitochondrial (p=0.0029) respiration showed significant changes with increasing stages of disc degeneration. No significant relationships were found for the association of respiration data with herniated or non-herniated status, or with subject age. Examination of mitochondrial ultrastructure in cultured annulus cells revealed unusual features which included mitochondrial inclusion bodies, poorly defined cristae and dark staining. Findings reported here are novel and document biochemical, metabolic, and morphologic abnormalities in mitochondria in cells from more degenerated annulus cells. Data suggest that the disc degenerative, not age, is a major factor associated with mitochondrial impairment, and also implicate oxidative stress, driven by mitochondrial dysfunction, as a major component within the degenerating disc. Findings have relevance to advancements in cell-based therapies to treat disc degeneration. (c) 2013 Orthopaedic Research Society Published by Wiley Periodicals, Inc. J Orthop Res 31:1270-1275, 2013
C1 [Gruber, Helen E.; Riley, Frank E.; Hanley, Edward N., Jr.] Carolinas Med Ctr, Cannon Res, Dept Orthopaed Surg, Charlotte, NC 28232 USA.
   [Watts, John A.; Fulkerson, Mary-Beth] Carolinas Med Ctr, Dept Emergency Med, Charlotte, NC 28226 USA.
   [Norton, H. James] Carolinas Med Ctr, Dept Biostat, Charlotte, NC 28226 USA.
C3 Carolinas Medical Center; Carolinas Medical Center; Carolinas Medical
   Center
RP Gruber, HE (corresponding author), Carolinas Med Ctr, Cannon Res, Dept Orthopaed Surg, Room 304,POB 32861, Charlotte, NC 28232 USA.
EM helen.gruber@carolinashealthcare.org
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NR 37
TC 24
Z9 31
U1 1
U2 7
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0736-0266
J9 J ORTHOP RES
JI J. Orthop. Res.
PD AUG
PY 2013
VL 31
IS 8
BP 1270
EP 1275
DI 10.1002/jor.22361
PG 6
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA 168RM
UT WOS:000320723400015
PM 23575904
DA 2025-06-11
ER

PT J
AU Patel, AY
   McDonald, TM
   Spears, LD
   Ching, JK
   Fisher, JS
AF Patel, Akshar Y.
   McDonald, Todd M.
   Spears, Larry D.
   Ching, James Kain
   Fisher, Jonathan S.
TI Ataxia telangiectasia mutated influences cytochrome c oxidase
   activity
SO BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
LA English
DT Article
DE Ataxia telangiectasia mutated; Cytochrome c oxidase; Mitochondria;
   Glucose 6-phosphate dehydrogenase; KU-55933
ID RAT SKELETAL-MUSCLE; ATM-DEFICIENT MICE; OXIDATIVE STRESS; MITOCHONDRIAL
   DYSFUNCTION; METABOLIC SYNDROME; DNA-DAMAGE; INSULIN; CELLS; ASTROCYTES;
   ACTIVATION
AB Cells lacking ataxia telangiectasia mutated (ATM) have impaired mitochondrial function. Furthermore, mammalian cells lacking ATM have increased levels of reactive oxygen species (ROS) as well as mitochondrial DNA (mtDNA) deletions in the region encoding for cytochrome c oxidase (COX). We hypothesized that ATM specifically influences COX activity in skeletal muscle. COX activity was similar to 40% lower in tibialis anterior from ATM-deficient mice than for wild-type mice (P < 0.01, n = 9/group). However, there were no ATM-related differences in activity of succinate dehydrogenase, isocitrate dehydrogenase, alpha-ketoglutarate dehydrogenase, mitochondrial glycerol 3-phosphate dehydrogenase, or complex III. Incubation of wild-type extensor digitorum longus muscles for 1 h with the ATM inhibitor KU55933 caused a similar to 50% reduction (P < 0.05, n = 5/group) in COX activity compared to muscles incubated with vehicle alone. Among the control muscles and muscles treated with the ATM inhibitor, COX activity was correlated (r = 0.61, P < 0.05) with activity of glucose 6-phosphate dehydrogenase, a key determinant of antioxidant defense through production of NADPH. Overall, the findings suggest that ATM has a protective role for COX activity. (C) 2011 Elsevier Inc. All rights reserved.
C1 [Patel, Akshar Y.; McDonald, Todd M.; Spears, Larry D.; Ching, James Kain; Fisher, Jonathan S.] St Louis Univ, Dept Biol, St Louis, MO 63103 USA.
C3 Saint Louis University
RP Fisher, JS (corresponding author), St Louis Univ, Dept Biol, 3507 Laclede Ave, St Louis, MO 63103 USA.
EM fisherjs@slu.edu
RI Fisher, Jonathan/A-3095-2008
OI Fisher, Jonathan/0000-0001-5170-2692; Spears, Larry/0000-0003-2797-684X
FU US Public Health service through National Institutes of Health
   [R15DK080437, R15DK080437-01S2]
FX This work was supported by the US Public Health service through National
   Institutes of Health Grants R15DK080437 and R15DK080437-01S2 (American
   Recovery and Reinvestment Act). The grant sponsor played no role in
   study design; in the collection, analysis and interpretation of data; in
   the writing of the report; or in the decision to submit the paper for
   publication.
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NR 29
TC 28
Z9 34
U1 0
U2 6
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0006-291X
EI 1090-2104
J9 BIOCHEM BIOPH RES CO
JI Biochem. Biophys. Res. Commun.
PD FEB 25
PY 2011
VL 405
IS 4
BP 599
EP 603
DI 10.1016/j.bbrc.2011.01.075
PG 5
WC Biochemistry & Molecular Biology; Biophysics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics
GA 731ZJ
UT WOS:000288149500014
PM 21266166
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Bengmark, S
AF Bengmark, Stig
TI Amplifiers of systemic inflammation - The role advanced glycation and
   lipoxidation end products in foods
SO KUWAIT MEDICAL JOURNAL
LA English
DT Review
DE antioxidants; acute diseases; chronic diseases; foods; glycation;
   inflammation; lipoxidation; Maillard products
ID N-EPSILON-CARBOXYMETHYLLYSINE; ILEX-PARAGUARIENSIS EXTRACTS; COWS MILK
   CONSUMPTION; STAGE RENAL-DISEASE; OXIDATIVE STRESS; DIETARY GLYCOTOXINS;
   MAILLARD REACTION; METABOLIC SYNDROME; PROTEIN GLYCATION;
   DIABETES-MELLITUS
AB Chronic diseases are repeatedly associated to accumulation in the body of glycated and lipoxidated proteins and peptides. PubMed reports in excess of 5000 papers plus about 14,000 articles about the related HbA(1c) RAGE, a member of the immunoglobulin super-family of cell surface molecules and receptor for advanced glycation end products, functions as a master switch, induces sustained activation of NF-kappa B, suppresses a series of endogenous auto-regulatory functions and converts long-lasting pro-inflammatory signals into sustained cellular dysfunction and disease. RAGE is activated by high levels of dys-functioning proteins in body fluids and tissues and is strongly associated with chronic diseases from allergy and Alzheimer to rheumatoid arthritis and urogenital disorders. Heat-treatment, irradiation and ionization of foods increase the content in foods of advanced glycated end-products (AGE) and advances lipoxidated end-products (ALE). Some processed foods, much like tobacco smoking are major contributors to accumulation of glycated and lipoxidated molecules in the tissues. Change of life style: avoidance of foods rich in deranged proteins and peptides and increased consumption of antioxidants, especially polyphenols counteracts such a development.
C1 [Bengmark, Stig] Univ London, UCL, Dept Hepatol, London, England.
   [Bengmark, Stig] Univ London, UCL, Dept Surg, London, England.
   [Bengmark, Stig] UCL, Sch Med, Inst Hepatol, London, England.
C3 University of London; University College London; University of London;
   University College London; University of London; University College
   London; UCL Medical School
RP Bengmark, S (corresponding author), 185 Barrier Point Rd, London E16 2SE, England.
EM s.bengmark@ucl.ac.uk
OI Bengmark, Stig/0000-0003-1809-8889
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NR 184
TC 4
Z9 4
U1 1
U2 17
PU KUWAIT MEDICAL ASSOC
PI SAFAT
PA PO BOX 1202, SAFAT, 13013, KUWAIT
SN 0023-5776
J9 KUWAIT MED J
JI Kuwait Med. J.
PD MAR
PY 2008
VL 40
IS 1
BP 3
EP 17
PG 15
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 341UY
UT WOS:000258741900002
DA 2025-06-11
ER

PT J
AU Henningsson, S
   Hakansson, A
   Westberg, L
   Baghaei, F
   Rosmond, R
   Holm, G
   Ekman, A
   Nissbrandt, H
   Eriksson, E
AF Henningsson, Susanne
   Hakansson, Anna
   Westberg, Lars
   Baghaei, Fariba
   Rosmond, Roland
   Holm, Goran
   Ekman, Agneta
   Nissbrandt, Hans
   Eriksson, Elias
TI Interleukin-6 gene polymorphism-174G/C influences plasma lipid
   levels in women
SO OBESITY
LA English
DT Article
DE interleukin-6; cytokines; cholesterol; cardiovascular; risk factors;
   lipids
ID MYOCARDIAL-INFARCTION; METABOLIC SYNDROME; NO ASSOCIATION; PROMOTER;
   OBESITY; STRESS; DISEASE
AB Elevated levels of the pro-inflammatory cytokine interleukin-6 (IL-6) have been associated with cardiovascular risk factors. The objective of this study was to investigate potential. associations between the promoter polymorphism IL-6 -174G/C and the following indices of metabolism: BMI, waist-to-hip ratio, and plasma levels of IL-6, cholesterol, low-density lipoprotein, triglycerides, high-density lipoprotein, leptin, and C-reactive protein in 252 42-year-old women and 245 51-year-old men. Subgroups were also studied 5 years later. The CC genotype of the IL-6 polymorphism was associated with lower levels of cholesterol and low-density lipoprotein (p < 0.001) in women. This finding was replicated in the follow-up, when a significant association between the CC genotype and low triglycerides was also observed. The association between the C allele and lipid pattern found in women was not found in men, where on the contrary, C carriers tended to display elevated triglycerides. IL-6 genotype was not associated with IL-6 plasma levels in either sample. The results suggest different effects of the IL-6 polymorphism on metabolic indices in women and men. None of the associations between IL-6 genotype and lipid pattern seemed to result from an effect of the polymorphism on IL-6 plasma levels.
C1 Univ Gothenburg, Sahlgrenska Acad, Dept Pharmacol, SE-40530 Gothenburg, Sweden.
   Univ Gothenburg, Sahlgrenska Acad, Cardiovasc Inst, SE-40530 Gothenburg, Sweden.
C3 University of Gothenburg; University of Gothenburg
RP Henningsson, S (corresponding author), Univ Gothenburg, Sahlgrenska Acad, Dept Pharmacol, Box 431, SE-40530 Gothenburg, Sweden.
EM susanne.henningsson@pharm.gu.se
RI Henningsson, Susanne/KPA-0980-2024; Baghaei, Fariba/HRD-7493-2023
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NR 20
TC 20
Z9 21
U1 0
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1930-7381
EI 1930-739X
J9 OBESITY
JI Obesity
PD NOV
PY 2006
VL 14
IS 11
BP 1868
EP 1873
DI 10.1038/oby.2006.216
PG 6
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 212OG
UT WOS:000249606100002
PM 17135599
OA Bronze
DA 2025-06-11
ER

PT J
AU Pack, AI
AF Pack, AI
TI Advances in sleep-disordered breathing
SO AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
LA English
DT Review
DE hypertension; metabolic syndrome; obesity; obstructive sleep apnea;
   sleep
ID POSITIVE AIRWAY PRESSURE; APNEA SYNDROME; BLOOD-PRESSURE; INTERMITTENT
   HYPOXIA; INSULIN-RESISTANCE; OXIDATIVE STRESS; CONTROLLED TRIAL;
   HEART-FAILURE; PREVALENCE; HYPOPNEA
AB Since the original clarification of the obstructive nature of obstructive sleep apnea (OSA) in 1965, much has been learned about the disorder. It is a condition with a high prevalence with obesity as a major risk factor. It aggregates in families, a relationship that is not simply explained by obesity. Premenopausal women are relatively protected from the disorder because OSA is uncommon in this group. Its prevalence in women rises after menopause. Although OSA is a risk factor for excessive sleepiness, there is developing evidence that it is also a risk factor for hypertension, acute cardiovascular events, and insulin resistance. The first line of therapy is nasal continuous positive airway pressure. Data as to the efficacy of continuous positive airway pressure in severe OSA have come from randomized, placebo-controlled clinical trials with the endpoints being sleepiness, quality of life, and 24-h ambulatory blood pressure. Data are currently less convincing for treatment outcomes in mild to moderate OSA, and new clinical trials to assess outcomes in this group are underway. Thus, even though this field only began toward the end of the first century of the American Thoracic Society, substantial progress has been made, and OSA has increasingly emerged as a major public health concern.
C1 Univ Penn, Sch Med, Ctr Sleep & Resp Neurobiol, Philadelphia, PA 19104 USA.
   Univ Penn, Sch Med, Div Sleep Med, Dept Med, Philadelphia, PA 19104 USA.
C3 University of Pennsylvania; University of Pennsylvania
RP Univ Penn, Sch Med, Ctr Sleep & Resp Neurobiol, 125 S 31st,Room 2120, Philadelphia, PA 19104 USA.
EM pack@mail.med.upenn.edu
OI Pack, Allan/0000-0002-2879-0484
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NR 107
TC 120
Z9 137
U1 0
U2 5
PU AMER THORACIC SOC
PI NEW YORK
PA 25 BROADWAY, 18 FL, NEW YORK, NY 10004 USA
SN 1073-449X
EI 1535-4970
J9 AM J RESP CRIT CARE
JI Am. J. Respir. Crit. Care Med.
PD JAN 1
PY 2006
VL 173
IS 1
BP 7
EP 15
DI 10.1164/rccm.200509-1478OE
PG 9
WC Critical Care Medicine; Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Respiratory System
GA 001GA
UT WOS:000234520400005
PM 16284108
DA 2025-06-11
ER

PT J
AU Ji, CX
   Wang, R
   Wang, DL
   Luo, YL
   Huang, ZM
   Liu, JY
   Cheng, AW
AF Ji, Chunxiao
   Wang, Rui
   Wang, Dongliang
   Luo, Yongle
   Huang, Zaiming
   Liu, Jianying
   Cheng, Anwei
TI Effect of berry-derived phenolic products on blood lipid profiles: A
   systematic review and meta-analysis
SO FOOD BIOSCIENCE
LA English
DT Review
DE Berries; Phenolics; Anthocyanins; Blood lipid; Meta-analysis
ID IMPROVES ENDOTHELIAL FUNCTION; RANDOMIZED CONTROLLED-TRIAL; METABOLIC
   SYNDROME; OXIDATIVE STRESS; DOUBLE-BLIND; ANTIOXIDANT CAPACITY;
   CLINICAL-TRIAL; ANTHOCYANINS; ADULTS; CHOLESTEROL
AB Berries, rich in phenolics with a C-ring, have numerous biological properties, such as antioxidant, antiinflammatory, regulating blood lipid metabolism, which is beneficial to human health. This study conducted a systematic review and meta-analysis of randomized clinical trials to verify the effect of berry-derived phenolic products (BDPP) supplementation on blood lipid profiles, including triglyceride (TG), total cholesterol (TC), lowdensity lipoprotein cholesterol (LDL-c), and high-density lipoprotein cholesterol (HDL-c). Thirty-seven clinical trials (2161 participants) fulfilled the eligibility criteria of the meta-analysis. A random effect model was applied in the meta-analysis, and results were expressed as WMD (weighted mean differences) with 95% CI (confidence intervals). Meta-analysis showed that BDPP supplementation resulted in a reduction in the TG (WMD = - 0.08), TC (WMD = - 0.14), and LDL-c (WMD = - 0.27), respectively; however, an increase trend was in the HDL-c (WMD = 0.05). In addition, subgroup analysis indicated that long-term duration of BDPP (>= 8 weeks) was more effective to the regulation of the blood lipid on the non-healthy and American subjects. Blood lipid regulation of BDPP intake may be attributed to their content and compounds of phytochemicals, mainly including phenolic acids, proanthocyanins and flavonoids.
C1 [Ji, Chunxiao; Wang, Dongliang; Liu, Jianying] Hunan Agr Univ, Coll Vet Med, Changsha 410128, Peoples R China.
   [Wang, Rui; Luo, Yongle; Huang, Zaiming; Cheng, Anwei] Hunan Agr Univ, Coll Food Sci & Technol, Engn Ctr Rapeseed Oil Nutr Hlth & Deep Dev Hunan P, Changsha 410128, Peoples R China.
   [Cheng, Anwei] Hunan Agr Univ, Coll Food Sci & Technol, 1 Nongda Rd, Changsha 410128, Peoples R China.
C3 Hunan Agricultural University; Hunan Agricultural University; Hunan
   Agricultural University
RP Cheng, AW (corresponding author), Hunan Agr Univ, Coll Food Sci & Technol, 1 Nongda Rd, Changsha 410128, Peoples R China.
EM anweich@126.com
RI Cheng, Anwei/HTP-9249-2023; LIU, JIANYING/KRP-1169-2024
OI cheng, an wei/0000-0003-2804-8471
FU Science and Technology Innovation Team of Hunan Province [2021RC4060];
   National Key Research and development program of China
FX This work was supported by Science and Technology Innovation Team of
   Hunan Province (2021RC4060) , and National Key Research and development
   program of China.
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NR 75
TC 0
Z9 0
U1 4
U2 14
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2212-4292
EI 2212-4306
J9 FOOD BIOSCI
JI Food Biosci.
PD APR
PY 2024
VL 58
AR 103607
DI 10.1016/j.fbio.2024.103607
EA FEB 2024
PG 16
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA NF7T0
UT WOS:001199110100001
DA 2025-06-11
ER

PT J
AU Liao, SJ
   Omage, SO
   Börmel, L
   Kluge, S
   Schubert, M
   Wallert, M
   Lorkowski, S
AF Liao, Sijia
   Omage, Sylvia Oghogho
   Boermel, Lisa
   Kluge, Stefan
   Schubert, Martin
   Wallert, Maria
   Lorkowski, Stefan
TI Vitamin E and Metabolic Health: Relevance of Interactions with Other
   Micronutrients
SO ANTIOXIDANTS
LA English
DT Review
DE vitamin E; micronutrients; interactions; co-supplementation; metabolic
   syndrome; immune response
ID AND/OR MINERAL SUPPLEMENTATION; BETA-CAROTENE SUPPLEMENTATION;
   TOCOPHEROL TRANSFER PROTEIN; INDUCED OXIDATIVE STRESS; LONG-CHAIN
   METABOLITES; CORONARY-HEART-DISEASE; KAPPA-B ACTIVATION;
   ALPHA-TOCOPHEROL; CARDIOVASCULAR-DISEASE; ANTIOXIDANT VITAMINS
AB A hundred years have passed since vitamin E was identified as an essential micronutrient for mammals. Since then, many biological functions of vitamin E have been unraveled in both cell and animal models, including antioxidant and anti-inflammatory properties, as well as regulatory activities on cell signaling and gene expression. However, the bioavailability and physiological functions of vitamin E have been considerably shown to depend on lifestyle, genetic factors, and individual health conditions. Another important facet that has been considered less so far is the endogenous interaction with other nutrients. Accumulating evidence indicates that the interaction between vitamin E and other nutrients, especially those that are enriched by supplementation in humans, may explain at least some of the discrepancies observed in clinical trials. Meanwhile, increasing evidence suggests that the different forms of vitamin E metabolites and derivates also exhibit physiological activities, which are more potent and mediated via different pathways compared to the respective vitamin E precursors. In this review, possible molecular mechanisms between vitamin E and other nutritional factors are discussed and their potential impact on physiological and pathophysiological processes is evaluated using published co-supplementation studies.
C1 [Liao, Sijia; Omage, Sylvia Oghogho; Boermel, Lisa; Kluge, Stefan; Schubert, Martin; Wallert, Maria; Lorkowski, Stefan] Friedrich Schiller Univ Jena, Inst Nutr Sci, D-07743 Jena, Germany.
   [Liao, Sijia; Omage, Sylvia Oghogho; Boermel, Lisa; Kluge, Stefan; Schubert, Martin; Wallert, Maria; Lorkowski, Stefan] Competence Cluster Nutr & Cardiovasc Hlth NutriCA, D-07743 Jena, Germany.
C3 Friedrich Schiller University of Jena
RP Lorkowski, S (corresponding author), Friedrich Schiller Univ Jena, Inst Nutr Sci, D-07743 Jena, Germany.; Lorkowski, S (corresponding author), Competence Cluster Nutr & Cardiovasc Hlth NutriCA, D-07743 Jena, Germany.
EM stefan.lorkowski@uni-jena.de
RI Wallert, Maria/T-4106-2019; Omage, Sylvia/AAZ-5743-2020; Lorkowski,
   Stefan/B-9689-2008
OI Schubert, Martin/0000-0001-8810-6675; Wallert,
   Maria/0000-0003-3796-0729; Omage, Sylvia/0000-0001-9296-7451; Lorkowski,
   Stefan/0000-0002-9649-840X; Liao, Sijia/0000-0003-0844-3909
FU Free State of Thuringia; European Social Fund [2019 FGR 0095]; Deutsche
   Forschungsgemeinschaft (DFG) [RTG 1715]; Deutscher Akademischer
   Austauschdienst (DAAD); IMPULSE [DRM/2019-01]; German Federal Ministry
   of Education and Research (nutriCARD) [01EA1411A]
FX S.L. (Sijia Liao), M.W. and S.L. (Stefan Lorkowski) were supported by
   the Free State of Thuringia and the European Social Fund (2019 FGR
   0095). Work of S.L. (Sijia Liao) and S.L. (Stefan Lorkowski) was
   supported by the Deutsche Forschungsgemeinschaft (DFG, RTG 1715). Work
   of S.O.O. was supported by the Deutscher Akademischer Austauschdienst
   (DAAD). Work of M.W. was supported by the IMPULSE (DRM/2019-01). Other
   sources of funding include the German Federal Ministry of Education and
   Research (nutriCARD, grant agreement number 01EA1411A).
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NR 209
TC 40
Z9 41
U1 1
U2 15
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD SEP
PY 2022
VL 11
IS 9
AR 1785
DI 10.3390/antiox11091785
PG 31
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA 4V6LM
UT WOS:000859586500001
PM 36139859
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Ning, P
   Jiang, XB
   Yang, J
   Zhang, JX
   Yang, F
   Cao, HY
AF Ning, Peng
   Jiang, Xiaobo
   Yang, Jing
   Zhang, Jiaxing
   Yang, Fan
   Cao, Hongyi
TI Mitophagy: A potential therapeutic target for insulin resistance
SO FRONTIERS IN PHYSIOLOGY
LA English
DT Review
DE mitophagy; autophagy; mitochondrial dysfunction; insulin resistance;
   therapeutic target
ID MITOCHONDRIAL DYSFUNCTION; OXIDATIVE STRESS; SKELETAL-MUSCLE; AUTOPHAGY;
   EXERCISE; RECRUITMENT; HOMEOSTASIS; BIOGENESIS; ACTIVATION; DYNAMICS
AB Glucose and lipid metabolism disorders caused by insulin resistance (IR) can lead to metabolic disorders such as diabetes, obesity, and the metabolic syndrome. Early and targeted intervention of IR is beneficial for the treatment of various metabolic disorders. Although significant progress has been made in the development of IR drug therapies, the state of the condition has not improved significantly. There is a critical need to identify novel therapeutic targets. Mitophagy is a type of selective autophagy quality control system that is activated to clear damaged and dysfunctional mitochondria. Mitophagy is highly regulated by various signaling pathways, such as the AMPK/mTOR pathway which is involved in the initiation of mitophagy, and the PINK1/Parkin, BNIP3/Nix, and FUNDC1 pathways, which are involved in mitophagosome formation. Mitophagy is involved in numerous human diseases such as neurological disorders, cardiovascular diseases, cancer, and aging. However, recently, there has been an increasing interest in the role of mitophagy in metabolic disorders. There is emerging evidence that normal mitophagy can improve IR. Unfortunately, few studies have investigated the relationship between mitophagy and IR. Therefore, we set out to review the role of mitophagy in IR and explore whether mitophagy may be a potential new target for IR therapy. We hope that this effort serves to stimulate further research in this area.
C1 [Ning, Peng; Yang, Jing; Zhang, Jiaxing; Yang, Fan; Cao, Hongyi] Chengdu Univ Tradit Chinese Med, Affiliated Peoples Hosp 5, Geriatr Dis Inst Chengdu, Canc Prevent & Treatment Inst Chengdu,Dept Endocri, Chengdu, Peoples R China.
   [Jiang, Xiaobo] Chengdu Univ Tradit Chinese Med, Chengdu Peoples Hosp 5, Affiliated Peoples Hosp 5, Geriatr Dis Inst Chengdu,Clin Med Coll 2,Canc Prev, Chengdu, Peoples R China.
C3 Chengdu University of Traditional Chinese Medicine; Chengdu University
   of Traditional Chinese Medicine
RP Yang, F; Cao, HY (corresponding author), Chengdu Univ Tradit Chinese Med, Affiliated Peoples Hosp 5, Geriatr Dis Inst Chengdu, Canc Prevent & Treatment Inst Chengdu,Dept Endocri, Chengdu, Peoples R China.
EM yangfan102522@qq.com; caohongyi66@126.com
RI Ning, Peng/GZG-9034-2022
OI Ning, Peng/0000-0002-1455-9919
FU Medical Scientific Research Project of Chengdu; Scientific Research Fund
   of Chengdu Fifth People's Hospital;  [2021272];  [GSPZX 2022-19]
FX Funding This project was supported by the Medical Scientific Research
   Project of Chengdu (No. 2021272), the Scientific Research Fund of
   Chengdu Fifth People's Hospital (No. GSPZX 2022-19).
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NR 96
TC 19
Z9 19
U1 6
U2 38
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1664-042X
J9 FRONT PHYSIOL
JI Front. Physiol.
PD AUG 23
PY 2022
VL 13
AR 957968
DI 10.3389/fphys.2022.957968
PG 11
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA 5O6GB
UT WOS:000872568200001
PM 36082218
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Witasp, A
   Luttropp, K
   Qureshi, AR
   Barany, P
   Heimbürger, O
   Wennberg, L
   Ekström, TJ
   Shiels, PG
   Stenvinkel, P
   Nordfors, L
AF Witasp, Anna
   Luttropp, Karin
   Qureshi, Abdul Rashid
   Barany, Peter
   Heimburger, Olof
   Wennberg, Lars
   Ekstrom, Tomas J.
   Shiels, Paul G.
   Stenvinkel, Peter
   Nordfors, Louise
TI Longitudinal genome-wide DNA methylation changes in response to kidney
   failure replacement therapy
SO SCIENTIFIC REPORTS
LA English
DT Article
ID ALPHA-INDUCED APOPTOSIS; VASCULAR CALCIFICATION; TRANSCRIPTION FACTOR;
   CELLULAR SENESCENCE; METABOLIC SYNDROME; DIABETES-MELLITUS; OXIDATIVE
   STRESS; GENE-EXPRESSION; DISEASE; GROWTH
AB Chronic kidney disease (CKD) is an emerging public health priority associated with high mortality rates and demanding treatment regimens, including life-style changes, medications or even dialysis or renal transplantation. Unavoidably, the uremic milieu disturbs homeostatic processes such as DNA methylation and other vital gene regulatory mechanisms. Here, we aimed to investigate how dialysis or kidney transplantation modifies the epigenome-wide methylation signature over 12 months of treatment. We used the Infinium HumanMethylation450 BeadChip on whole blood samples from CKD-patients undergoing either dialysis (n = 11) or kidney transplantation (n = 12) and 24 age- and sex-matched population-based controls. At baseline, comparison between patients and controls identified several significant (P-FDR < 0.01) CpG methylation differences in genes with functions relevant to inflammation, cellular ageing and vascular calcification. Following 12 months, the global DNA methylation pattern of patients approached that seen in the control group. Notably, 413 CpG sites remained differentially methylated at follow-up in both treatment groups compared to controls. Together, these data indicate that the uremic milieu drives genome-wide methylation changes that are partially reversed with kidney failure replacement therapy. Differentially methylated CpG sites unaffected by treatment may be of particular interest as they could highlight candidate genes for kidney disease per se.
C1 [Witasp, Anna; Qureshi, Abdul Rashid; Barany, Peter; Heimburger, Olof; Stenvinkel, Peter; Nordfors, Louise] Karolinska Univ Hosp, Karolinska Inst, Dept Clin Sci Intervent & Technol, Div Renal Med, M99, S-14186 Stockholm, Sweden.
   [Luttropp, Karin; Ekstrom, Tomas J.] Ctr Mol Med, Karolinska Inst, Stockholm, Sweden.
   [Luttropp, Karin; Ekstrom, Tomas J.] Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden.
   [Wennberg, Lars] Karolinska Univ Hosp, Dept Clin Sci Intervent & Technol, Div Transplantat Surg, Stockholm, Sweden.
   [Shiels, Paul G.] Univ Glasgow, Coll Med, Vet & Life Sci Inst Canc Sci, Glasgow, Lanark, Scotland.
C3 Karolinska Institutet; Karolinska University Hospital; Karolinska
   Institutet; Karolinska Institutet; Karolinska Institutet; Karolinska
   University Hospital; University of Glasgow
RP Nordfors, L (corresponding author), Karolinska Univ Hosp, Karolinska Inst, Dept Clin Sci Intervent & Technol, Div Renal Med, M99, S-14186 Stockholm, Sweden.
EM louise.nordfors@telia.com
RI Barany, Peter/I-6116-2019; Ekström, Tomas/B-7764-2013; Qureshi,
   Abdul/G-1358-2010
FU Swedish Research Council; Strategic Research Program in Diabetes
   (Karolinska Institutet); Strategic Research Program in Diabetes (Umea
   University); Njurfonden; Stiftelsen Stig och Gunborg Westman
FX The authors express their sincere gratitude to the Bioinformatics and
   Expression Analysis core facility (Karolinska Institutet, Stockholm,
   Sweden) for their assistance in the analysis of the Infinium
   HumanMethylation450 BeadChips. The authors would especially like to
   thank Karin Edvardsson for assistance with the statistical analysis of
   the raw data. The work of LN and PS was supported by Swedish Research
   Council grants. PS is also funded by the Strategic Research Program in
   Diabetes (Karolinska Institutet and Umea University). PS and AW hold
   grants from Njurfonden and Stiftelsen Stig och Gunborg Westman. None of
   the funding bodies had a role in study design, data collection, data
   analysis, data interpretation, or manuscript writing.
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NR 99
TC 11
Z9 12
U1 0
U2 3
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD JAN 10
PY 2022
VL 12
IS 1
AR 470
DI 10.1038/s41598-021-04321-5
PG 14
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA YF2LV
UT WOS:000741645800055
PM 35013499
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Lee, J
   Geng, S
   Li, S
   Li, LW
AF Lee, Jiyoung
   Geng, Shuo
   Li, Song
   Li, Liwu
TI Single Cell RNA-Seq and Machine Learning Reveal Novel Subpopulations in
   Low-Grade Inflammatory Monocytes With Unique Regulatory Circuits
SO FRONTIERS IN IMMUNOLOGY
LA English
DT Article
DE monocyte; machine learning; inflammation; regulatory motifs; single cell
   analysis
ID MACROPHAGE DIFFERENTIATION; STRESS; ENDOTOXEMIA; DISEASE;
   ATHEROSCLEROSIS; TECHNOLOGIES; POLARIZATION; ASSOCIATION; MODULATION;
   INHIBITION
AB Subclinical doses of LPS (SD-LPS) are known to cause low-grade inflammatory activation of monocytes, which could lead to inflammatory diseases including atherosclerosis and metabolic syndrome. Sodium 4-phenylbutyrate is a potential therapeutic compound which can reduce the inflammation caused by SD-LPS. To understand the gene regulatory networks of these processes, we have generated scRNA-seq data from mouse monocytes treated with these compounds and identified 11 novel cell clusters. We have developed a machine learning method to integrate scRNA-seq, ATAC-seq, and binding motifs to characterize gene regulatory networks underlying these cell clusters. Using guided regularized random forest and feature selection, our method achieved high performance and outperformed a traditional enrichment-based method in selecting candidate regulatory genes. Our method is particularly efficient in selecting a few candidate genes to explain observed expression pattern. In particular, among 531 candidate TFs, our method achieves an auROC of 0.961 with only 10 motifs. Finally, we found two novel subpopulations of monocyte cells in response to SD-LPS and we confirmed our analysis using independent flow cytometry experiments. Our results suggest that our new machine learning method can select candidate regulatory genes as potential targets for developing new therapeutics against low grade inflammation.
C1 [Lee, Jiyoung; Li, Song] Virginia Polytech Inst & State Univ, PhD Program Genet Bioinformat & Computat Biol, Blacksburg, VA 24061 USA.
   [Lee, Jiyoung; Li, Song] Virginia Polytech Inst & State Univ, Sch Plant & Environm Sci, Blacksburg, VA 24061 USA.
   [Geng, Shuo; Li, Liwu] Virginia Polytech Inst & State Univ, Dept Biol Sci, Blacksburg, VA 24061 USA.
C3 Virginia Polytechnic Institute & State University; Virginia Polytechnic
   Institute & State University; Virginia Polytechnic Institute & State
   University
RP Li, S (corresponding author), Virginia Polytech Inst & State Univ, PhD Program Genet Bioinformat & Computat Biol, Blacksburg, VA 24061 USA.; Li, S (corresponding author), Virginia Polytech Inst & State Univ, Sch Plant & Environm Sci, Blacksburg, VA 24061 USA.; Li, LW (corresponding author), Virginia Polytech Inst & State Univ, Dept Biol Sci, Blacksburg, VA 24061 USA.
EM songli@vt.edu; lwli@vt.edu
RI Geng, Shuo/J-3735-2013; Lee, Jiyoung/ABB-1401-2021
OI Li, Liwu/0000-0001-8870-5299; Lee, Jiyoung/0000-0003-1702-874X
FU Jeffress Trust Awards Program in Interdisciplinary Research; NIH
   [R01HL115835]; National Heart Lung and Blood Institute [R01HL115835]
   Funding Source: NIH RePORTER
FX This work was supported by the Jeffress Trust Awards Program in
   Interdisciplinary Research to SL, as well as NIH R01HL115835 to LL.
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NR 73
TC 13
Z9 13
U1 1
U2 22
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-3224
J9 FRONT IMMUNOL
JI Front. Immunol.
PD FEB 23
PY 2021
VL 12
AR 627036
DI 10.3389/fimmu.2021.627036
PG 17
WC Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology
GA QT0MA
UT WOS:000626285700001
PM 33708217
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Zhou, JY
   Yang, YF
   Wang, HJ
   Bian, BL
   Yang, J
   Wei, XL
   Zhou, YY
   Si, N
   Zhao, HY
AF Zhou, Junyi
   Yang, Yifei
   Wang, Hongjie
   Bian, Baolin
   Yang, Jian
   Wei, Xiaolu
   Zhou, Yanyan
   Si, Nan
   Zhao, Haiyu
TI The Disturbance of Hepatic and Serous Lipids in Aristolochic Acid Ι
   Induced Rats for Hepatotoxicity Using Lipidomics Approach
SO MOLECULES
LA English
DT Article
DE aristolochic acid Iota; hepatotoxicity; lipidomics; biomarkers
ID METABOLIC SYNDROME; LIVER; SPHINGOLIPIDS; PHOSPHATIDYLCHOLINE;
   ASSOCIATIONS; APOPTOSIS; CIRRHOSIS; STRESS; INJURY
AB Aristolochic acid I (AAI) was regarded as the major toxic component of aristolochic acid (AA). In addition to aristolochic acid nephropathy (AAN), liver cancers induced by AAI has aroused increasing attention recently. In this paper, the discovery of diagnostic biomarkers for AAI-induced liver injury has been studied, especially for the lipid markers. From the histopathological characteristics, the injury was observed clearly in the liver apart from the kidney after 30 mg/kg of AA Iota treatment for one week, while the lesion alleviated after AA Iota discontinuance. The serum biochemical indexes were manifested to the normal tendency after AA Iota discontinuance for two weeks. According to the evaluation of pathology slices and serum biochemical indexes, they indicated that the hepatotoxicity induced by AA Iota was reversible to some extent. A total of 44 lipid markers were identified in the liver, as well as 59 in the serum. Twenty-six common lipid markers were observed in both serum and liver. Furthermore, nine out of 26 lipids exhibited the excellent diagnostic ability to differentiate the control group from the AA Iota group and AA Iota discontinuance group with high sensitivity and specificity. The changed lipid markers might serve as characteristics to explain the mechanisms of pathogenesis and progression in hepatotoxicity induced by AA Iota.
C1 [Zhou, Junyi; Yang, Yifei; Wang, Hongjie; Bian, Baolin; Yang, Jian; Wei, Xiaolu; Zhou, Yanyan; Si, Nan; Zhao, Haiyu] China Acad Chinese Med Sci, Inst Chinese Mat Med, Beijing 100700, Peoples R China.
C3 China Academy of Chinese Medical Sciences; Institute of Chinese Materia
   Medica, CACMS
RP Si, N; Zhao, HY (corresponding author), China Acad Chinese Med Sci, Inst Chinese Mat Med, Beijing 100700, Peoples R China.
EM zzjjyyy@163.com; yangyifei1987@163.com; hjwang@icmm.ac.cn;
   blbian@icmm.ac.cn; jyang@icmm.ac.cn; xlwei@icmm.ac.cn;
   yyzhou@icmm.ac.cn; nsi@icmm.ac.cn; hyzhao@icmm.ac.cn
RI Yang, Yifei/HJA-0450-2022; Zhou, Junyi/U-6333-2019; si,
   nan/IUQ-0440-2023; Zhou, Yanyan/MGT-3937-2025; Wei, Xiaolu/HTO-7227-2023
FU National Science and Technology Major Project [2015ZX09501004-003-001,
   2018ZX09101002-003]; China Academy of Chinese Medical Sciences
   Foundation [ZZ10-025, ZZ12-001]; Major International SAMP;T Cooperation
   Project from Ministry of Science and Technology of the People's Republic
   of China [2016YFE0129000]
FX This research was funded by the National Science and Technology Major
   Project (2015ZX09501004-003-001 and 2018ZX09101002-003), China Academy
   of Chinese Medical Sciences Foundation (ZZ10-025 and ZZ12-001), and the
   Major International S&T Cooperation Project from Ministry of Science and
   Technology of the People's Republic of China (No. 2016YFE0129000).
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NR 42
TC 13
Z9 16
U1 0
U2 17
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1420-3049
J9 MOLECULES
JI Molecules
PD OCT
PY 2019
VL 24
IS 20
AR 3745
DI 10.3390/molecules24203745
PG 14
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA JM5JE
UT WOS:000496249500114
PM 31627392
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Djordjevic, DB
   Zdravkovic, M
   Nagorni, A
   Manolis, A
   Tsioufis, C
   Lovic, D
AF Djordjevic, Dragan B.
   Zdravkovic, Marija
   Nagorni, Aleksandar
   Manolis, Athanasios
   Tsioufis, Costas
   Lovic, Dragan
TI A Critical Approach of Guideline Therapeutic Recommendations for NAFLD
SO CURRENT VASCULAR PHARMACOLOGY
LA English
DT Review
DE Non-alcoholic fatty liver disease; non-alcoholic steatohepatitis;
   cardiovascular disease; insulin resistance; diabetes; obesity; statins
ID NONALCOHOLIC FATTY LIVER; SERUM ALANINE AMINOTRANSFERASE;
   CORONARY-HEART-DISEASE; CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME;
   HEPATIC STEATOSIS; NATURAL-HISTORY; LIFE-STYLE; HISTOLOGICAL SEVERITY;
   AMERICAN ASSOCIATION
AB Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) as progressive form of the disease are associated with cardiovascular risk factors including obesity, dyslipidaemia, hyperglycaemia and hypertension. When NAFLD is associated with cardiovascular disease, mortality of NAFLD patients is increased due to cardiovascular disease. Prevalence of NAFLD and NASH is high, but it seems that epidemic of the disease is under-recognized and under-appreciated. Linking pathophysiological mechanisms are complex and still not well understood. The main related pathophysiological mechanisms are lipid factors, insulin resistance, inflammation, proinflammatory cytokines, oxidative stress, pro-coagulant status, hyperglycaemia and adipokines. First-line management focuses on lifestyle modifications in both diseases. Several therapeutic interventions, insulin sensitizer agents, lipid lowering drugs, antioxidants, such as vitamin E, have been proposed. Statins appear to be safe, but their use in the treatment of NAFLD and NASH is under-appreciated. Many different agents are being investigated as future drugs for the treatment of this clinical entity. The aim of the review is to examine the extent of the epidemic and the mediating mechanisms, to critically evaluate current guideline recommendations, and to consider current and future medications for this disease.
C1 [Djordjevic, Dragan B.] Univ Nis, Med Fac, Inst Niska Banja, Nish, Serbia.
   [Zdravkovic, Marija] Univ Belgrade, Clin Hosp Bezaniska Kosa, Sch Med, Belgrade, Serbia.
   [Nagorni, Aleksandar] Univ Nis, Med Fac, Nish, Serbia.
   [Manolis, Athanasios] Asklepe Hosp, Athens, Greece.
   [Tsioufis, Costas] Univ Athens, Cardiol Dept, Athens, Greece.
   [Lovic, Dragan] Intermedica, Clin Internal Dis, Nish, Serbia.
C3 University of Nis; University of Belgrade; University of Nis; National &
   Kapodistrian University of Athens
RP Lovic, D (corresponding author), Intermedica, Clin Internal Dis, Nish, Serbia.
EM draganl1@sbb.rs
RI Cífková, Renata/O-5731-2017; Zdravkovic, Marija/MAH-8312-2025;
   Djordjevic, Dragan/ABC-7327-2020
OI Lovic, Dragan/0000-0002-0685-2605; Zdravkovic,
   Marija/0000-0003-4059-0263; Djordjevic, Dragan/0000-0003-4966-0168
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NR 146
TC 9
Z9 9
U1 0
U2 4
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1570-1611
EI 1875-6212
J9 CURR VASC PHARMACOL
JI Current Vascular Pharmacology
PY 2018
VL 16
IS 3
BP 228
EP 238
DI 10.2174/1570161115666170621080228
PG 11
WC Pharmacology & Pharmacy; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Cardiovascular System & Cardiology
GA GC2QM
UT WOS:000429627700005
PM 28676026
DA 2025-06-11
ER

PT J
AU Meng, WY
   Zhang, J
   Hou, H
   Yu, L
   Dong, P
AF Meng, Wenya
   Zhang, Jing
   Hou, Hu
   Yu, Long
   Dong, Ping
TI Exploring the structures and molecular mechanisms of bioactive compounds
   from marine foods for hyperuricemia prevention: a systematic review
SO CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
LA English
DT Review; Early Access
DE Peptide; polysaccharide; lipids and small molecules; hyperuricemia;
   structure-activity relationship
ID CUCUMBER ACAUDINA-MOLPADIOIDES; URIC-ACID; SULFATED POLYSACCHARIDES;
   ANTIOXIDANT ACTIVITY; METABOLIC SYNDROME; XANTHINE-OXIDASE; FATTY-ACIDS;
   FUCOIDAN; PEPTIDES; PURIFICATION
AB Hyperuricemia, characterized by an elevation in serum uric acid (UA) levels, stands as a significant metabolic ailment threatening human well-being. Presently, dietary adjustments have become a crucial strategy in managing serum UA levels among individuals grappling with hyperuricemia and gout. Given its unique ecosystem, the ocean hosts a plethora of organisms boasting distinct structures and active components. The marine bioactive substances, such as bioactive peptides, polysaccharides, lipids, and small molecules, have garnered attention in the research and development of modern functional foods and biomedicine due to their profound efficacy and distinctive compositions. Notably, the functional components of marine foods have been studied for their potential in preventing hyperuricemia. However, the precise molecular mechanism underlying their actions remain incompletely elucidated. This review article highlights the diversity of marine active compounds and the latest progress in understanding urate-lowering mechanism. Principal mechanisms primarily encompass the regulation of UA metabolism, maintenance of intestinal homeostasis, mitigation of inflammatory responses, and alleviation of oxidative stress. Furthermore, we scrutinized the constraints of prior studies and provided recommendations. In sum, this article furnished a valuable resource concerning the intervention of bioactive compounds sourced from marine foods in the context of hyperuricemia.
C1 [Meng, Wenya; Zhang, Jing; Hou, Hu; Dong, Ping] Ocean Univ China, Sch Food Sci & Engn, Qingdao 266000, Peoples R China.
   [Yu, Long] Flinders Univ S Australia, Coll Med & Publ Hlth, Adelaide, Australia.
C3 Ocean University of China; Flinders University South Australia
RP Dong, P (corresponding author), Ocean Univ China, Sch Food Sci & Engn, Qingdao 266000, Peoples R China.; Yu, L (corresponding author), Flinders Univ S Australia, Coll Med & Publ Hlth, Adelaide, Australia.
EM long.yu@flinders.edu.au; dongping@ouc.edu.cn
OI Yu, Long/0000-0002-6020-3905
FU National Key R&D Program of China [2018YFD0901105]; Major Scientific and
   Technological Innovation Project of Shandong Province [2022CXGC020414];
   Taishan Scholar Foundation of Shandong Province [tsqn202103033]
FX The authors gratefully acknowledge the financial support by National Key
   R&D Program of China (No. 2018YFD0901105), Major Scientific and
   Technological Innovation Project of Shandong Province (No.
   2022CXGC020414), and Taishan Scholar Foundation of Shandong Province
   (No. tsqn202103033).
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NR 159
TC 1
Z9 1
U1 17
U2 17
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1040-8398
EI 1549-7852
J9 CRIT REV FOOD SCI
JI Crit. Rev. Food Sci. Nutr.
PD 2025 FEB 7
PY 2025
DI 10.1080/10408398.2025.2464700
EA FEB 2025
PG 19
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA 1LS4E
UT WOS:001468010700001
PM 40020721
DA 2025-06-11
ER

PT J
AU Soleimanzad, H
   Morisset, C
   Montaner, M
   Pain, F
   Magnan, C
   Tanter, M
   Gurden, H
AF Soleimanzad, Haleh
   Morisset, Clementine
   Montaner, Mireia
   Pain, Frederic
   Magnan, Christophe
   Tanter, Mickal
   Gurden, Hirac
TI Western diet since adolescence impairs brain functional hyperemia at
   adulthood in mice: rescue by a balanced ω-3:ω-6 polyunsaturated fatty
   acids ratio
SO INTERNATIONAL JOURNAL OF OBESITY
LA English
DT Article
ID INSULIN-RESISTANCE; OBESITY; AGE; SUPPLEMENTATION; DYSFUNCTION;
   CHILDREN; STRESS; IMPACT; MASS
AB Background/ObjectiveObesity is a devastating worldwide metabolic disease, with the highest prevalence in children and adolescents. Obesity impacts neuronal function but the fate of functional hyperemia, a vital mechanism making possible cerebral blood supply to active brain areas, is unknown in organisms fed a high-caloric Western Diet (WD) since adolescence.Subjects/MethodsWe mapped changes in cerebral blood volume (CBV) in the somatosensory cortex in response to whisker stimulation in adolescent, adult, and middle-aged mice fed a WD since adolescence. To this aim, we used non-invasive and high-resolution functional ultrasound imaging (fUS).ResultsWe efficiently mimicked the metabolic syndrome of adolescents in young mice with early weight gain, dysfunctional glucose homeostasis, and insulinemia. Functional hyperemia is compromised as early as 3 weeks of WD and remains impaired after that in adolescent mice. These findings highlight the cerebrovascular vulnerability to WD during adolescence. In WD, omega-6:omega-3 polyunsaturated fatty acids (PUFAs) ratio is unbalanced towards proinflammatory omega-6. A balanced omega-6:omega-3 PUFAs ratio in WD achieved by docosahexaenoic acid supplementation efficiently restores glucose homeostasis and functional hyperemia in adults.ConclusionsWD triggers a rapid impairment in cerebrovascular activity in adolescence, which is maintained at older ages, and can be rescued by a PUFA-based nutraceutical approach.
C1 [Soleimanzad, Haleh; Morisset, Clementine; Tanter, Mickal] PSL Res Univ, Phys Med Paris, ESPCI Paris, INSERM,CNRS, F-75015 Paris, France.
   [Montaner, Mireia; Magnan, Christophe; Gurden, Hirac] Univ Paris Cite, Unit Funct & Adapt Biol BFA, UMR 8251, CNRS, F-75013 Paris, France.
   [Pain, Frederic] Univ Paris Saclay, Inst Opt Grad Sch, CNRS, Lab Charles Fabry, F-91127 Palaiseau, France.
   [Montaner, Mireia] Univ Cambridge, Inst Metab Sci & MRC Metab Dis Unit, Cambridge, England.
C3 Centre National de la Recherche Scientifique (CNRS); Universite PSL;
   Ecole Superieure de Physique et de Chimie Industrielles de la Ville de
   Paris (ESPCI); Institut National de la Sante et de la Recherche Medicale
   (Inserm); Universite Paris Cite; Centre National de la Recherche
   Scientifique (CNRS); CNRS - National Institute for Biology (INSB);
   Institut Polytechnique de Paris; Ecole Polytechnique; Centre National de
   la Recherche Scientifique (CNRS); Universite Paris Saclay; University of
   Cambridge
RP Tanter, M (corresponding author), PSL Res Univ, Phys Med Paris, ESPCI Paris, INSERM,CNRS, F-75015 Paris, France.; Gurden, H (corresponding author), Univ Paris Cite, Unit Funct & Adapt Biol BFA, UMR 8251, CNRS, F-75013 Paris, France.
EM mickael.tanter@espci.fr; hirac.gurden@u-paris.fr
RI Pain, Frederic/AET-9578-2022
FU NIH; AXA; Idex Universite Paris Cite; AXA Research Fund
FX HS had a postdoctoral fellowship award from NIH and AXA. MM had a
   doctoral fellowship award from Idex Universite Paris Cite. This work was
   supported by the AXA Research Fund (MT).
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NR 86
TC 0
Z9 0
U1 4
U2 4
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0307-0565
EI 1476-5497
J9 INT J OBESITY
JI Int. J. Obes.
PD MAY
PY 2025
VL 49
IS 5
BP 844
EP 854
DI 10.1038/s41366-025-01711-x
EA FEB 2025
PG 11
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 2XS1A
UT WOS:001415242600001
PM 39910250
DA 2025-06-11
ER

PT J
AU Raberin, A
   Burtscher, J
   Burtscher, M
   Millet, GP
AF Raberin, Antoine
   Burtscher, Johannes
   Burtscher, Martin
   Millet, Gregoire P.
TI Hypoxia and the Aging Cardiovascular System
SO AGING AND DISEASE
LA English
DT Review
DE elderly; altitude; blood pressure; hypoxia conditioning; older
   individuals
ID CORONARY-ARTERY-DISEASE; BLOOD-PRESSURE RESPONSE; PULMONARY
   VASCULAR-RESPONSE; MAXIMAL HEART-RATE; HIGH-ALTITUDE; INTERMITTENT
   HYPOXIA; MODERATE ALTITUDE; CARDIORESPIRATORY RESPONSE; EXERCISE
   PERFORMANCE; METABOLIC SYNDROME
AB Older individuals represent a growing population, in industrialized countries, particularly those with cardiovascular diseases, which remain the leading cause of death in western societies. Aging constitutes one of the largest risks for cardiovascular diseases. On the other hand, oxygen consumption is the foundation of cardiorespiratory fitness, which in turn is linearly related to mortality, quality of life and numerous morbidities. Therefore, hypoxia is a stressor that induces beneficial or harmful adaptations, depending on the dose. While severe hypoxia can exert detrimental effects, such as high-altitude illnesses, moderate and controlled oxygen exposure can potentially be used therapeutically. It can improve numerous pathological conditions, including vascular abnormalities, and potentially slows down the progression of various age-related disorders. Hypoxia can exert beneficial effects on inflammation, oxidative stress, mitochondrial functions, and cell survival, which are all increased with age and have been discussed as main promotors of aging. This narrative review discusses specificities of the aging cardiovascular system in hypoxia. It draws upon an extensive literature search on the effects of hypoxia/altitude interventions (acute, prolonged, or intermittent exposure) on the cardiovascular system in older individuals (over 50 years old). Special attention is directed toward the use of hypoxia exposure to improve cardiovascular health in older individuals.
C1 [Raberin, Antoine; Burtscher, Johannes; Millet, Gregoire P.] Univ Lausanne, Inst Sport Sci, CH-1015 Lausanne, Switzerland.
   [Burtscher, Martin] Univ Innsbruck, Dept Sport Sci, A-6020 Innsbruck, Austria.
C3 University of Lausanne; University of Innsbruck
RP Raberin, A (corresponding author), Univ Lausanne, Inst Sport Sci, Fac Biol & Med, CH-1015 Lausanne, Switzerland.
EM antoine.raberin@unil.ch
RI Burtscher, Martin/M-7015-2019; Burtscher, Johannes/AAO-3065-2020;
   Millet, Gregoire/F-4104-2012; Raberin, Antoine/IYS-9077-2023
OI Raberin, Antoine/0000-0001-5032-8301
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NR 158
TC 12
Z9 12
U1 3
U2 16
PU INT SOC AGING & DISEASE
PI FORT WORTH
PA EDITORIAL OFF, 3400 CAMP BOWIE BLVD, FORT WORTH, TX 76106 USA
SN 2152-5250
J9 AGING DIS
JI Aging Dis.
PD NOV 27
PY 2023
VL 14
IS 6
BP 2051
EP 2070
DI 10.14336/AD.2023.0424
EA MAY 2023
PG 20
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA GO1Y8
UT WOS:000992513700001
PM 37199587
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Nunes, S
   Vieira, P
   Gomes, P
   Viana, SD
   Reis, F
AF Nunes, Sara
   Vieira, Pedro
   Gomes, Pedro
   Viana, Sofia Domingues
   Reis, Flavio
TI Blueberry as an Attractive Functional Fruit to Prevent (Pre)Diabetes
   Progression
SO ANTIOXIDANTS
LA English
DT Review
DE blueberries; antioxidants; prediabetes; hepatic dysmetabolism; gut
   microbiota dysbiosis
ID VACCINIUM-ANGUSTIFOLIUM CONSUMPTION; INDUCED OXIDATIVE STRESS; SERUM
   ANTIOXIDANT STATUS; INSULIN-RESISTANCE; WILD BLUEBERRY; IN-VITRO;
   PHENOLIC-COMPOUNDS; METABOLIC SYNDROME; GLUCOSE-TOLERANCE; GUT
   MICROBIOTA
AB Prediabetes, a subclinical impairment between euglycemia and hyperglycemia, is a risk factor for the development of type 2 diabetes mellitus (T2DM) and associated micro- and macrovascular complications. Lifestyle therapy, the first-line treatment of prediabetes, includes physical exercise and dietary regimens enriched in phytochemicals with health-related properties. Blueberries (Vaccinium spp.), given their pleasant taste and great abundance in beneficial phytochemicals, have gained public interest all over the world. Along with a high antioxidant activity, this functional fruit is also well-recognized due to its hypoglycemic and insulin-sensitizing effects and has been recommended for overt T2DM management. Yet blueberries target several other pathophysiological traits, namely gut microbiota dysbiosis and hepatic dysmetabolism, that ensue when prediabetes begins and for which pharmacological interventions tend to be delayed. In this work, we revisited preclinical data from in vitro assays, animal models and human studies, aiming to disclose the potential mechanisms by which blueberries may be a fruitful source of phytochemicals able to prevent (pre)diabetes progression. Collectively, future efforts should focus on longer-term studies with standardized interventions and readouts, particularly in humans, that will hopefully bring more robust evidence and concrete guidance for blueberries' effective use in prediabetes.
C1 [Nunes, Sara; Vieira, Pedro; Gomes, Pedro; Viana, Sofia Domingues; Reis, Flavio] Univ Coimbra, Fac Med, Inst Pharmacol & Expt Therapeut, P-3000548 Coimbra, Portugal.
   [Nunes, Sara; Vieira, Pedro; Gomes, Pedro; Viana, Sofia Domingues; Reis, Flavio] Univ Coimbra, Fac Med, Coimbra Inst Clin & Biomed Res iCBR, P-3000548 Coimbra, Portugal.
   [Nunes, Sara; Vieira, Pedro; Gomes, Pedro; Viana, Sofia Domingues; Reis, Flavio] Univ Coimbra, Ctr Innovat Biomed & Biotechnol CIBB, P-3004504 Coimbra, Portugal.
   [Nunes, Sara; Vieira, Pedro; Gomes, Pedro; Viana, Sofia Domingues; Reis, Flavio] Clin Acad Ctr Coimbra CACC, P-3004504 Coimbra, Portugal.
   [Gomes, Pedro] Univ Porto, Fac Med, Dept Biomed, P-4200450 Porto, Portugal.
   [Gomes, Pedro] Univ Porto, CINTESIS Ctr Hlth Technol & Serv Res, P-4200450 Porto, Portugal.
   [Viana, Sofia Domingues] Polytech Inst Coimbra, ESTESC Coimbra Hlth Sch, Pharm Biomed Lab Sci, P-3046854 Coimbra, Portugal.
C3 Universidade de Coimbra; Universidade de Coimbra; Universidade de
   Coimbra; Universidade de Coimbra; Universidade do Porto; Universidade do
   Porto
RP Viana, SD; Reis, F (corresponding author), Univ Coimbra, Fac Med, Inst Pharmacol & Expt Therapeut, P-3000548 Coimbra, Portugal.; Viana, SD; Reis, F (corresponding author), Univ Coimbra, Fac Med, Coimbra Inst Clin & Biomed Res iCBR, P-3000548 Coimbra, Portugal.; Viana, SD; Reis, F (corresponding author), Univ Coimbra, Ctr Innovat Biomed & Biotechnol CIBB, P-3004504 Coimbra, Portugal.; Viana, SD; Reis, F (corresponding author), Clin Acad Ctr Coimbra CACC, P-3004504 Coimbra, Portugal.; Viana, SD (corresponding author), Polytech Inst Coimbra, ESTESC Coimbra Hlth Sch, Pharm Biomed Lab Sci, P-3046854 Coimbra, Portugal.
EM spnunes@fmed.uc.pt; pedromdvieira96@gmail.com; pgomes70@gmail.com;
   sofia.viana@uc.pt; freis@fmed.uc.pt
RI Reis, Flávio/E-7077-2016; Nunes, Sara Raquel/GNH-1874-2022; Vieira,
   Pedro/HTS-2811-2023; Viana, Sofia/CAJ-2253-2022; Nunes, Sara
   Raquel/G-5141-2017; Gomes, Pedro/H-9449-2013
OI Reis, Flavio/0000-0003-3401-9554; Nunes, Sara
   Raquel/0000-0002-0240-9059; Gomes, Pedro/0000-0003-1766-9133; Viana,
   Sofia/0000-0002-1316-1319; Vieira, Pedro/0000-0002-9287-4068
FU European Regional Development Fund (FEDER), through Programa Operacional
   Factores de Competitividade COMPETE2020
   [CENTRO-01-0145-FEDER-000012-HealthyAging2020]; Portuguese Science and
   Technology Foundation (FCT) [UID/NEU/04539/2013, UID/NEU/04539/2019,
   UIDB/04539/2020, UIDP/04539/2020, SFRH/BD/109017/2015,
   PTDC/SAU-NUT/31712/2017]; COMPETE-FEDER funds
   [POCI-01-0145-FEDER-007440, POCI-01-0145-FEDER-031712]; Fundação para a
   Ciência e a Tecnologia [IF/00405/2014/CP1222/CT0007, PRAXIS
   XXI/BD/3261/94, IF/00951/2014/CP1222/CT0006, PRAXIS XXI/BD/3259/94,
   IF/00631/2014/CP1221/CT0004, PRAXIS XXI/BD/3250/94] Funding Source: FCT
FX This work was supported by the European Regional Development Fund
   (FEDER), through Programa Operacional Factores de Competitividade
   COMPETE2020 (CENTRO-01-0145-FEDER-000012-HealthyAging2020) and by
   National funds via Portuguese Science and Technology Foundation (FCT):
   Strategic Projects UID/NEU/04539/2013, UID/NEU/04539/2019,
   UIDB/04539/2020 and UIDP/04539/2020 (CIBB), SFRH/BD/109017/2015 (PhD
   Fellowship) and PTDC/SAU-NUT/31712/2017, as well as by COMPETE-FEDER
   funds (POCI-01-0145-FEDER-007440 and POCI-01-0145-FEDER-031712).
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NR 175
TC 28
Z9 28
U1 4
U2 51
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD AUG
PY 2021
VL 10
IS 8
AR 1162
DI 10.3390/antiox10081162
PG 23
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA UF6EB
UT WOS:000688663900001
PM 34439410
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Hasegawa, H
   Yatomi, K
   Mitome-Mishima, Y
   Miyamoto, N
   Tanaka, R
   Oishi, H
   Arai, H
   Hattori, N
   Urabe, T
AF Hasegawa, Hiroshi
   Yatomi, Kenji
   Mitome-Mishima, Yumiko
   Miyamoto, Nobukazu
   Tanaka, Ryota
   Oishi, Hidenori
   Arai, Hajime
   Hattori, Nobutaka
   Urabe, Takao
TI Pioglitazone Prevents Hemorrhagic Infarction After Transient Focal
   Ischemia in Type 2 Diabetes
SO NEUROSCIENCE RESEARCH
LA English
DT Article
DE PPAR-y agonist; adiponectin; matrix metalloproteinase 9; type 2
   diabetes; hemorrhagic infarction; neuroprotective effect
ID BLOOD-BRAIN-BARRIER; CEREBRAL-ISCHEMIA; STROKE; GLUCOSE;
   MATRIX-METALLOPROTEINASE-9; ADIPONECTIN; ACTIVATION; EDEMA; DB/DB
AB Pioglitazone (PGZ), a PPAR-y agonist, has been used for diabetic patients as an insulin-sensitizing agent. Recent studies have demonstrated that PGZ increases adiponectin (APN) levels and provides vascular protection in ischemic conditions. This study was designed to assess the neuroprotective effects of PGZ against cerebral ischemia-reperfusion injury via an APN-related mechanism. Type 2 diabetic leptindeficient mice (db/db) were administered PGZ for 1 week, and plasma insulin and APN levels were measured. These mice received a middle cerebral artery occlusion and reperfusion injury, and they were evaluated for the infarct volume and by immunohistochemistry and western blotting analysis at several time points after ischemia. PGZ-administered db/db mice showed improved insulin sensitivity, and the hemorrhagic rate and infarct volume were decreased (P < 0.05). In the PGZ-administered group, plasma APN levels increased compared with the vehicle group. In the db/db group, PGZ administration significantly suppressed inflammatory reactions and oxidative stress after reperfusion (P < 0.05). PGZ may be applicable for acute cerebral ischemia treatment in metabolic syndrome patients as well as antidiabetic agents. (c) 2020 Elsevier B.V. and Japan Neuroscience Society. All rights reserved.
C1 [Hasegawa, Hiroshi] Juntendo Univ, Dept Neurosurg, Shizuoka Hosp, Shizuoka, Japan.
   [Miyamoto, Nobukazu; Hattori, Nobutaka] Juntendo Univ, Dept Neurol, Sch Med, Tokyo, Japan.
   [Yatomi, Kenji; Mitome-Mishima, Yumiko; Oishi, Hidenori; Arai, Hajime] Juntendo Univ, Dept Neurosurg, Sch Med, Tokyo, Japan.
   [Oishi, Hidenori] Juntendo Univ, Neuroendovasc Therapy, Sch Med, Tokyo, Japan.
   [Tanaka, Ryota] Jichi Med Univ, Dept Med, Stroke Ctr, Shimotsuke, Tochigi, Japan.
   [Tanaka, Ryota] Jichi Med Univ, Dept Med, Div Neurol, Shimotsuke, Tochigi, Japan.
   [Urabe, Takao] Juntendo Univ, Urayasu Hosp, Dept Neurol, Chiba, Japan.
C3 Juntendo University; Juntendo University; Juntendo University; Juntendo
   University; Jichi Medical University; Jichi Medical University; Juntendo
   University
RP Miyamoto, N (corresponding author), Juntendo Univ, Sch Med, Dept Neurol, Bunkyo Ku, 2-1-1 Hongo, Tokyo 1138421, Japan.
EM nobu-m@juntendo.ac.jp
RI Hattori, Nobutaka/ACR-0069-2022
OI Tanaka, Ryota/0000-0003-3158-1955; Mitome-Mishima,
   Yumiko/0000-0001-8545-616X
FU High Technology Research Center grant; Ministry of Education, Culture,
   Sports, Science and Technology, Japan
FX This study was supported in part by a High Technology Research
   Centergrant and a Grant-in-Aid for Exploratory Research from the
   Ministry of Education, Culture, Sports, Science and Technology, Japan.
   We gratefully acknowledge the Laboratory of Biomedical Research
   Resources and Laboratory of Morphology and Image Anal-ysis of Juntendo
   Research Support Center.
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NR 29
TC 4
Z9 5
U1 0
U2 9
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0168-0102
EI 1872-8111
J9 NEUROSCI RES
JI Neurosci. Res.
PD SEP
PY 2021
VL 170
BP 314
EP 321
DI 10.1016/j.neures.2020.09.004
EA JUL 2021
PG 8
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA TT3JR
UT WOS:000680247700004
PM 33309864
DA 2025-06-11
ER

PT J
AU Jackson, SE
   Kirschbaum, C
   Steptoe, A
AF Jackson, Sarah E.
   Kirschbaum, Clemens
   Steptoe, Andrew
TI Hair Cortisol and Adiposity in a Population-Based Sample of 2,527 Men
   and Women Aged 54 to 87 Years
SO OBESITY
LA English
DT Article
ID PITUITARY-ADRENAL AXIS; BODY-MASS INDEX; METABOLIC SYNDROME; CHRONIC
   STRESS; FOOD CHOICE; SCALP HAIR; OBESITY; APPETITE
AB Objective: Chronic cortisol exposure is hypothesized to contribute to obesity. This study examined associations between hair cortisol concentrations, a novel indicator of long-term cortisol exposure, and adiposity in a large population-based sample.
   Methods: Data were from 2,527 men and women aged 54 and older (98% white British) participating in the English Longitudinal Study of Ageing. Hair cortisol concentrations were determined from the scalpnearest 2 cm hair segment, and height, weight, and waist circumference were objectively measured. Covariates included age, sex, socioeconomic status, smoking status, diabetes, and arthritis.
   Results: In cross-sectional analyses, hair cortisol concentrations were positively correlated with weight (r = 0.102, P < 0.001), BMI ( r = 0.101, P < 0.001), and waist circumference ( r = 0.082, P = 0.001) and were significantly elevated in participants with obesity ( BMI >= 30 kg/m(2)) ( F = 6.58, P = 0.001) and raised waist circumference ( >= 102 cm in men, >= 88 cm in women) ( F = 4.87, P = 0.027). Hair cortisol levels were also positively associated with the persistence of obesity ( F = 12.70, P < 0.001), evaluated in retrospect over 4 years.
   Conclusions: Chronic exposure to elevated cortisol concentrations, assessed in hair, is associated with markers of adiposity and with the persistence of obesity over time.
C1 [Jackson, Sarah E.; Steptoe, Andrew] UCL, Dept Epidemiol & Publ Hlth, London, England.
   [Kirschbaum, Clemens] Tech Univ Dresden, Dept Psychol, Dresden, Germany.
C3 University of London; University College London; Technische Universitat
   Dresden
RP Jackson, SE (corresponding author), UCL, Dept Epidemiol & Publ Hlth, London, England.
EM s.e.jackson@ucl.ac.uk
RI Kirschbaum, Clemens/AAB-1752-2020; Steptoe, Andrew/Y-2440-2019; Jackson,
   Sarah/J-9046-2019
OI Jackson, Sarah/0000-0001-5658-6168
FU Cancer Research UK [C1418/A14133]
FX This work was supported by a grant from Cancer Research UK
   (C1418/A14133).
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NR 40
TC 101
Z9 117
U1 1
U2 14
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1930-7381
EI 1930-739X
J9 OBESITY
JI Obesity
PD MAR
PY 2017
VL 25
IS 3
BP 539
EP 544
DI 10.1002/oby.21733
PG 6
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA EQ4IP
UT WOS:000398040000012
PM 28229550
OA Green Published, hybrid, Green Submitted
DA 2025-06-11
ER

PT J
AU Sahini, N
   Borlak, J
AF Sahini, Nishika
   Borlak, Juergen
TI Recent insights into the molecular pathophysiology of lipid droplet
   formation in hepatocytes
SO PROGRESS IN LIPID RESEARCH
LA English
DT Review
DE Hepatocyte; Lipid droplets; Non-alcoholic fatty liver disease (NAFLD);
   Lipotoxicity; Metabolic syndrome; Cellular cross talks
ID FATTY LIVER-DISEASE; ENDOPLASMIC-RETICULUM STRESS; ACTIVATED
   RECEPTOR-ALPHA; ACYL-COA SYNTHETASE; HEPATIC CHOLESTEROL ACCUMULATION;
   DIACYLGLYCEROL ACYLTRANSFERASE 1; ENRICHED TRANSCRIPTION FACTORS;
   INSULIN-RESISTANCE; NONALCOHOLIC STEATOHEPATITIS; BINDING-PROTEIN
AB Triacyglycerols are a major energy reserve of the body and are normally stored in adipose tissue as lipid droplets (LDs). The liver, however, stores energy as glycogen and digested triglycerides in the form of fatty acids. In stressed condition such as obesity, imbalanced nutrition and drug induced liver injury hepatocytes accumulate excess lipids in the form of LDs whose prolonged storage leads to disease conditions most notably non-alcoholic fatty liver disease (NAFLD). Fatty liver disease has become a major health burden with more than 90% of obese, nearly 70% of overweight and about 25% of normal weight patients being affected. Notably, research in recent years has shown LD as highly dynamic organelles for maintaining lipid homeostasis through fat storage, protein sorting and other molecular events studied in adipocytes and other cells of living organisms. This review focuses on the molecular events of LD formation in hepatocytes and the importance of cross talk between different cell types and their signalling in NAFLD as to provide a perspective on molecular mechanisms as well as possibilities for different therapeutic intervention strategies. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Sahini, Nishika; Borlak, Juergen] Zentrum Pharmakol & Toxikol, Medizin Hsch Hannover, D-30625 Hannover, Germany.
C3 Hannover Medical School
RP Borlak, J (corresponding author), Zentrum Pharmakol & Toxikol, Medizin Hsch Hannover, Carl Neuberg Str 1, D-30625 Hannover, Germany.
EM borlak.juergen@mh-hannover.de
FU Virtual Liver Network of the German Federal Ministry of Education and
   Research (BMBF) [031 6154]
FX We gratefully acknowledge support from The Virtual Liver Network (grant
   031 6154) of the German Federal Ministry of Education and Research
   (BMBF) to J.B.
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NR 325
TC 94
Z9 96
U1 1
U2 65
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0163-7827
EI 1873-2194
J9 PROG LIPID RES
JI Prog. Lipid Res.
PD APR
PY 2014
VL 54
BP 86
EP 112
DI 10.1016/j.plipres.2014.02.002
PG 27
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA AH7WJ
UT WOS:000336345800006
PM 24607340
DA 2025-06-11
ER

PT J
AU Najafian, J
   Mohamadifard, N
   Siadat, ZD
   Sadri, G
   Rahmati, MR
AF Najafian, J.
   Mohamadifard, N.
   Siadat, Z. D.
   Sadri, G.
   Rahmati, M. R.
TI Association between sleep duration and diabetes mellitus: Isfahan
   Healthy Heart Program
SO NIGERIAN JOURNAL OF CLINICAL PRACTICE
LA English
DT Article
DE Diabetes mellitus; glucose tolerance; sleep
ID GLYCEMIC CONTROL; POPULATION; STRESS; MEN; DISTURBANCES; MORTALITY;
   WOMEN; RISK; LIFE
AB Background: Recent studies revealed an association between sleep disturbance and metabolic disorders, such as obesity and metabolic syndrome. An aim of this study was to assess the relation between sleep duration and diabetes mellitus in a representative sample of the Iranian population. Materials and Methods: Participants were 12514 individuals, (6123 men and 6391 women) studied in the baseline survey of a community based program entitled Isfahan healthy heart program (IHHP). Sleep time was obtained by validated questionnaire. Diabetes mellitus was defined as fasting glucose over 126 mg/dl or 2 hour post prandial glucose at glucose tolerance test over 200 mg/dl, or if the patient was on diabetic medication. The relation between the sleep time and diabetes was examined using categorical logistic regression with adjustment for sex, body mass index and waist circumference. Results: Compared with those, sleeping 7-8 hours per night, the individuals with sleeping time of 5 hours or less and aged < 60 years had an increased odd ratio for diabetes and an impaired glucose tolerance. (OR = 1.37 and 95 CI = 1.13, 1.67). Conclusion: Sleep duration of 5 hours or less in individuals under age 60 years is associated with an increased prevalence of diabetes mellitus and an impaired glucose tolerance test. This finding should be confirmed in longitudinal studies.
C1 [Najafian, J.] Isfahan Univ Med Sci, Isfahan Cardiovasc Res Ctr, Isfahan Cardiovasc Res Inst, Esfahan, Iran.
   [Mohamadifard, N.] Isfahan Univ Med Sci, Isfahan Cardiovasc Res Inst, Hypertens Res Ctr, Esfahan, Iran.
   [Siadat, Z. D.; Sadri, G.] Isfahan Univ Med Sci, Sch Med, Esfahan, Iran.
   [Rahmati, M. R.] Arak Univ Med Sci, Arak Hlth Ctr, Arak, Iran.
C3 Isfahan University of Medical Sciences; Isfahan University of Medical
   Sciences; Isfahan University of Medical Sciences
RP Najafian, J (corresponding author), Isfahan Univ Med Sci, Isfahan Cardiovasc Res Ctr, Isfahan Cardiovasc Res Inst, Sadigheh Tahereh Res Ctr, Khoram St,POB 81465-1148, Esfahan, Iran.
EM Jamshid_najafian@yahoo.com
RI Najafian, Jamshid/W-2357-2017; Mohammadifard, Noushin/M-2244-2018;
   siadat, zahra/W-1895-2017
OI siadat, zahra dana/0000-0002-3048-2325; Najafian,
   Jamshid/0000-0002-1472-1218
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NR 24
TC 33
Z9 41
U1 0
U2 8
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, 400059, INDIA
SN 1119-3077
J9 NIGER J CLIN PRACT
JI Niger. J. Clin. Pract.
PD JAN-MAR
PY 2013
VL 16
IS 1
BP 59
EP 62
DI 10.4103/1119-3077.106756
PG 4
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 109JP
UT WOS:000316363600013
PM 23377472
DA 2025-06-11
ER

PT J
AU Fort, J
AF Fort, J
TI Chronic renal failure: A cardiovascular risk factor
SO KIDNEY INTERNATIONAL
LA English
DT Article; Proceedings Paper
CT 2nd International Conference on New Insights in Progression of Chronic
   Kidney Disease
CY MAY 08-10, 2005
CL Barcelona, SPAIN
SP Spanish Soc Nephrol
DE chronic renal disease; cardiovascular risk; morbi-mortality
ID CHRONIC KIDNEY-DISEASE; LEFT-VENTRICULAR DISORDERS; METABOLIC SYNDROME;
   ENDOTHELIAL DYSFUNCTION; VASCULAR CALCIFICATION; MORTALITY RISK; ANEMIA;
   MILD; ERYTHROPOIETIN; INSUFFICIENCY
AB The risk of developing cardiovascular disease is greatly increased in patients undergoing renal replacement therapy and, notably, morbidity and mortality due to therapy is much higher in these patients than in the general population. Minimal alterations in renal function, as evidenced by reduced glomerular filtration rate and the presence of albuminuria, have been described as potent cardiovascular risk factors.
   The classic risk factors only partly explain this difference; hence, we must admit the existence of known and emerging factors associated with increased cardiovascular risk in patients with renal disease. This article provides a review of these factors. It describes the role of hyperphosphoremia and elevated calcium-phosphorous product in the formation of cardiovascular calcifications, the contribution of anemia to left ventricular hypertrophy, and the consequences of accelerated atherogenesis with oxidative stress and a microinflammatory state resulting from endothelial dysfunction. Hyperhomocysteinemia, increased sympathetic nervous system activity, lipoprotein alterations with elevated lipoprotein A, and increases in the concentrations of asymmetrical dimethyl-arginine are other examples of the changes described in this population.
   Patients with renal disease should be considered to be at high risk for developing cardiovascular disease and candidates for implementation of secondary prevention strategies. It is for this reason that early identification of renal failure, which remains hidden in many cases, is of prime importance.
C1 Univ Autonoma Barcelona, Hosp Gen Univ Vall Hebron, Serv Nefrol, Barcelona, Spain.
C3 Autonomous University of Barcelona; Hospital Universitari Vall d'Hebron
RP Univ Autonoma Barcelona, Hosp Gen Univ Vall Hebron, Serv Nefrol, Barcelona, Spain.
EM 9159jfr@comb.es
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NR 51
TC 37
Z9 46
U1 0
U2 2
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0085-2538
EI 1523-1755
J9 KIDNEY INT
JI Kidney Int.
PD DEC
PY 2005
VL 68
SU 99
BP 25
EP 29
PG 5
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Urology & Nephrology
GA 982ZN
UT WOS:000233201000007
OA Bronze
DA 2025-06-11
ER

PT J
AU Abdalla, MMI
AF Abdalla, Mona Mohamed Ibrahim
TI Insulin resistance as the molecular link between diabetes and
   Alzheimer's disease
SO WORLD JOURNAL OF DIABETES
LA English
DT Review
DE Alzheimer's disease; Insulin resistance; Obesity; Dementia; Diabetes;
   Metabolic syndrome
ID BLOOD-BRAIN-BARRIER; ENDOGENOUS GLUCOSE-PRODUCTION;
   CENTRAL-NERVOUS-SYSTEM; COGNITIVE IMPAIRMENT; OXIDATIVE STRESS;
   GENE-EXPRESSION; AMYLOID-BETA; NEURODEGENERATIVE DISEASES; CEREBRAL
   HYPOPERFUSION; DIETARY RESTRICTION
AB Diabetes mellitus (DM) and Alzheimer's disease (AD) are two major health concerns that have seen a rising prevalence worldwide. Recent studies have indicated a possible link between DM and an increased risk of developing AD. Insulin, while primarily known for its role in regulating blood sugar, also plays a vital role in protecting brain functions. Insulin resistance (IR), especially prevalent in type 2 diabetes, is believed to play a significant role in AD's development. When insulin signalling becomes dysfunctional, it can negatively affect various brain functions, making individuals more susceptible to AD's defining features, such as the buildup of beta-amyloid plaques and tau protein tangles. Emerging research suggests that addressing insulin-related issues might help reduce or even reverse the brain changes linked to AD. This review aims to explore the rela-tionship between DM and AD, with a focus on the role of IR. It also explores the molecular mechanisms by which IR might lead to brain changes and assesses current treatments that target IR. Understanding IR's role in the connection between DM and AD offers new possibilities for treatments and highlights the importance of continued research in this interdisciplinary field.
C1 [Abdalla, Mona Mohamed Ibrahim] Int Med Univ, Sch Med, Dept Human Biol, 126 Jln Jalil Perkasa 19, Bukit Jalil 57000, Kuala Lumpur, Malaysia.
C3 International Medical University Malaysia
RP Abdalla, MMI (corresponding author), Int Med Univ, Sch Med, Dept Human Biol, 126 Jln Jalil Perkasa 19, Bukit Jalil 57000, Kuala Lumpur, Malaysia.
EM monamohamed@imu.edu.my
RI Abdalla, Mona/AAQ-6286-2021
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NR 240
TC 13
Z9 13
U1 2
U2 6
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 7041 Koll Center Parkway, Suite 160, PLEASANTON, CA, UNITED STATES
EI 1948-9358
J9 WORLD J DIABETES
JI World J. Diabetes
PD JUL 15
PY 2024
VL 15
IS 7
DI 10.4239/wjd.v15.i7.1430
PG 19
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA A4B1H
UT WOS:001281989200017
PM 39099819
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Smail, L
   Hamlat, N
   Berdja, S
   Boumaza, S
   Neggazi, S
   Kacimi, G
   Boudarene, L
   Bouguerra, SA
AF Smail, Leila
   Hamlat, Nadjiba
   Berdja, Sihem
   Boumaza, Saliha
   Neggazi, Samia
   Kacimi, Ghouti
   Boudarene, Lynda
   Bouguerra, Souhila Aouichat
TI Effect of Brassica rapa var. rapifera on
   Insulin Resistance and Inflammatory Analysis of Visceral Adipose Tissue
   of Obese Wistar Rats Under Glucolipotoxicity Condition
SO INTERNATIONAL JOURNAL OF MORPHOLOGY
LA English
DT Article
DE Brassica rapa; AEBr; Diabetic; Glucolipotoxicity; Visceral adipose
   tissue.
ID EXTRACT; L.
AB Obesity -related pathophysiologies such as insulin resistance and the metabolic syndrome show a markedly increased risk for type 2 diabetes and atherosclerotic cardiovascular disease. This risk appears to be linked to alterations in adipose tissue function, leading to chronic inflammation and the dysregulation of adipocyte-derived factors. Brassica rapa have been used in traditional medicine for the treatment of several diseases, including diabetes.. This study aimed to investigate the effect of nutritional stress induced by a high -fat and high -sucrose diet on the pathophysiology of visceral adipose tissue and the therapeutic effect of Brassica rapa in male Wistar rats. We subjected experimental rats to a high -fat (10 %) high -sucrose (20 %)/per day for 11 months and treated them for 20 days with aqueous extract Br (AEBr) at 200 mg/kg at the end of the experiment. At the time of sacrifice, we monitored plasma and tissue biochemical parameters as well as the morpho-histopathology of visceral adipose tissue. We found AEBr corrected metabolic parameters and inflammatory markers in homogenized visceral adipose tissue and reduced hypertrophy, hyperplasia, and lipid droplets. These results suggest that AEBr enhances anti -diabetic, anti-inflammatory and a protective effect on adipose tissue morphology in type 2 diabetes and obesity.
C1 [Smail, Leila; Hamlat, Nadjiba; Berdja, Sihem; Boumaza, Saliha; Neggazi, Samia; Bouguerra, Souhila Aouichat] Univ Sci & Technol, Fac Biol Sci, Lab Physiol Organisms Team Cellular & Mol Physiopa, USTHB BP 32 El Alia, Algiers 16011, Algeria.
   [Kacimi, Ghouti] Cent Hosp Army, Lab Biochem, Algiers 16005, Algeria.
   [Boudarene, Lynda] USTHB, Fac Chem, Lab Organ & Funct Anal, BP 32 El Alia, Algiers 16011, Algeria.
   [Smail, Leila] Univ Sci & Technol Houari Boumedienne, USTHB, Fac Biol Sci, Algiers, Algeria.
C3 University Science & Technology Houari Boumediene; University Science &
   Technology Houari Boumediene
RP Smail, L (corresponding author), Univ Sci & Technol Houari Boumedienne, USTHB, Fac Biol Sci, Algiers, Algeria.
EM leila84.smail@gmail.com
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PU SOC CHILENA ANATOMIA
PI TEMUCO
PA CASILLA 54-D, TEMUCO, 00000, CHILE
SN 0717-9502
EI 0717-9367
J9 INT J MORPHOL
JI Int. J. Morphol.
PD FEB
PY 2024
VL 42
IS 1
BP 197
EP 204
PG 8
WC Anatomy & Morphology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Anatomy & Morphology
GA GV0E4
UT WOS:001155321900009
DA 2025-06-11
ER

PT J
AU Xiang, XW
   Jiang, QH
   Yang, HS
   Zhou, XX
   Chen, YF
   Chen, H
   Liu, SL
   Chen, L
AF Xiang, Xingwei
   Jiang, Qihong
   Yang, Hongshun
   Zhou, Xuxia
   Chen, Yufeng
   Chen, Hui
   Liu, Shulai
   Chen, Lin
TI A review on shellfish polysaccharides: Extraction, characterization and
   amelioration of metabolic syndrome
SO FRONTIERS IN NUTRITION
LA English
DT Review
DE shellfish polysaccharides; extraction and purification; lipid
   metabolism; metabolic disorders; shellfish
ID ASSISTED ENZYMATIC EXTRACTION; WATER-SOLUBLE POLYSACCHARIDE;
   MYTILUS-EDULIS EXTRACT; SULFATED POLYSACCHARIDES; CRASSOSTREA-GIGAS; GUT
   MICROBIOTA; PURIFIED POLYSACCHARIDE; ANTIOXIDANT ACTIVITY; OXIDATIVE
   STRESS; PROTECTIVE ROLE
AB Shellfish are diverse, widely distributed organisms that are a rich source of biological resources. Polysaccharides are an important components in shellfish, hence a great deal of attention has been directed at isolation and characterization of shellfish polysaccharides because of their numerous health benefits. Differences in shellfish species, habits, and environment result in the diversity of the structure and composition of polysaccharides. Thus, shellfish polysaccharides possess special biological activities. Studies have shown that shellfish polysaccharides exert biological activities, including antioxidant, antitumor, immune-regulation, hypolipidemic, antihypertensive, and antihyperglycemic effects, and are widely used in cosmetics, health products, and medicine. This review spotlights the extraction and purification methods of shellfish polysaccharides and analyses their structures, biological activities and conformational relationships; discusses the regulatory mechanism of shellfish polysaccharides on hyperlipidemia, hypertension, and hyperglycemia caused by lipid metabolism disorders; and summarizes its alleviation of lipid metabolism-related diseases. This review provides a reference for the in-depth development and utilization of shellfish polysaccharides as a functional food to regulate lipid metabolism-related diseases. To achieve high value utilization of marine shellfish resources while actively promoting the development of marine biological industry and health industry.
C1 [Xiang, Xingwei; Jiang, Qihong; Zhou, Xuxia; Chen, Yufeng; Chen, Hui; Liu, Shulai] Zhejiang Univ Technol, Coll Food Sci & Technol, Hangzhou, Peoples R China.
   [Xiang, Xingwei; Jiang, Qihong; Zhou, Xuxia; Chen, Yufeng; Chen, Hui; Liu, Shulai] Key Lab Marine Fishery Resources Exploitment & Uti, Hangzhou, Peoples R China.
   [Xiang, Xingwei; Jiang, Qihong; Zhou, Xuxia; Chen, Yufeng; Chen, Hui; Liu, Shulai] Natl R&D Branch Ctr Pelag Aquat Prod Proc Hangzhou, Hangzhou, Peoples R China.
   [Jiang, Qihong; Chen, Lin] Zhejiang Acad Agr Sci, Inst Sericultural & Tea, Hangzhou, Peoples R China.
   [Yang, Hongshun] Natl Univ Singapore, Dept Food Sci & Technol, Singapore, Singapore.
C3 Zhejiang University of Technology; Zhejiang Academy of Agricultural
   Sciences; National University of Singapore
RP Liu, SL (corresponding author), Zhejiang Univ Technol, Coll Food Sci & Technol, Hangzhou, Peoples R China.; Liu, SL (corresponding author), Key Lab Marine Fishery Resources Exploitment & Uti, Hangzhou, Peoples R China.; Liu, SL (corresponding author), Natl R&D Branch Ctr Pelag Aquat Prod Proc Hangzhou, Hangzhou, Peoples R China.; Chen, L (corresponding author), Zhejiang Acad Agr Sci, Inst Sericultural & Tea, Hangzhou, Peoples R China.
EM slliu@zjut.edu.cn; chenlinsdau@163.com
RI Yang, Hongshun/F-1842-2010; Liu, Shulai/JCO-2703-2023; Chen,
   Lin/G-3516-2013; Zhou, Xuxia/ACS-0757-2022
OI Chen, Lin/0000-0002-6727-0529; Liu, Shulai/0000-0002-6416-5897; Zhou,
   Xuxia/0000-0002-7059-839X
FU National Key Research and Development Program of China; 
   [2020YFD0900902]
FX Funding This work was supported by grants from National Key Research and
   Development Program of China (2020YFD0900902).
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NR 144
TC 13
Z9 13
U1 13
U2 175
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD SEP 13
PY 2022
VL 9
AR 974860
DI 10.3389/fnut.2022.974860
PG 23
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 4X9QP
UT WOS:000861171000001
PM 36176638
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Shahwan, M
   Alhumaydhi, F
   Ashraf, GM
   Hasan, PMZ
   Shamsi, A
AF Shahwan, Moyad
   Alhumaydhi, Fahad
   Ashraf, Ghulam Md
   Hasan, Prince M. Z.
   Shamsi, Anas
TI Role of polyphenols in combating Type 2 Diabetes and insulin resistance
SO INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
LA English
DT Review
DE Polyphenols; Type 2 diabetes; Insulin resistance
ID ACTIVATED PROTEIN-KINASE; DECREASE GLUCOSE-UPTAKE; BETA-CELL FUNCTION;
   MAJOR FOOD SOURCES; DIETARY POLYPHENOLS; OXIDATIVE STRESS; GREEN TEA;
   METABOLIC-SYNDROME; ALPHA-GLUCOSIDASE; EPIGALLOCATECHIN GALLATE
AB Compromised carbohydrate metabolism leading to hyperglycemia is the primary metabolic disorder of non-insulin-dependent diabetes mellitus. Reformed digestion and altered absorption of carbohydrates, exhaustion of glycogen stock, enhanced gluconeogenesis and overproduced hepatic glucose, dysfunction of beta-cell, resistance to insulin in peripheral tissue, and impaired insulin signaling pathways are essential reasons for hyperglycemia. Although oral anti-diabetic drugs like alpha-glucosidase inhibitors, sulfonylureas and insulin therapies are commonly used to manage Type 2 Diabetes (T2D) and hyperglycemia, natural compounds in diet also play a significant role in combating the effect of diabetes. Due to their vast bioavailability and anti-hyperglycemic effect with least or no side effects, polyphenolic compounds have gained wide popularity. Polyphenols such as flavonoids and tannins play a significant role in carbohydrate metabolism by inhibiting key enzymes responsible for the digestion of carbohydrates to glucose, viz. alpha-glucosidase and alpha-amylase. Several polyphenols such as resveratrol, epigallocatechin-3-gallate (EGCG) and quercetin enhanced glucose uptake in the muscles and adipocytes by translocating GLUT4 to plasma membrane mainly by the activation of the AMP-activated protein kinase (AMPK) pathway. This review provides an insight into the protective role of polyphenols in T2D, highlighting the aspects of insulin resistance.
C1 [Shahwan, Moyad; Shamsi, Anas] Ajman Univ, Ctr Med & Bioallied Hlth Sci Res, Ajman, U Arab Emirates.
   [Shahwan, Moyad] Ajman Univ, Coll Pharm & Hlth Sci, Ajman, U Arab Emirates.
   [Alhumaydhi, Fahad] Qassim Univ, Coll Appl Med Sci, Dept Med Labs, Buraydah, Saudi Arabia.
   [Ashraf, Ghulam Md] King Abdulaziz Univ, King Fand Med Res Ctr, Preclin Res Unit, Jeddah, Saudi Arabia.
   [Hasan, Prince M. Z.] King Abdulaziz Univ, Ctr Nanotechnol, POB 80216, Jeddah 21589, Saudi Arabia.
   [Shamsi, Anas] Jamia Millia Islamia, Ctr Interdisciplinary Res Basic Sci, New Delhi 110025, India.
C3 Ajman University; Ajman University; Qassim University; King Abdulaziz
   University; King Abdulaziz University; Jamia Millia Islamia
RP Shamsi, A (corresponding author), Jamia Millia Islamia, Ctr Interdisciplinary Res Basic Sci, New Delhi 110025, India.
EM anas.shamsi18@gmail.com
RI Zyoud, Samer/ABI-6476-2020; Hasan, Ziaul/J-4182-2017; SHAMSI,
   ANAS/AAW-2124-2020; Alhumaydhi, Fahad/Z-3879-2019; Ashraf, Ghulam
   Md/H-9485-2012
OI shahwan, moyad/0000-0001-8367-4841; SHAMSI, ANAS/0000-0001-7055-7056;
   Alhumaydhi, Fahad/0000-0002-0151-8309; Ashraf, Ghulam
   Md/0000-0002-9820-2078
FU College of Pharmacy, Ajman University [2020-IRG-PH-09]; Deanship of
   Scientific Research (DSR) at King Abdulaziz University, Jeddah, Saudi
   Arabia [FP-93-42]
FX AS and MS are highly grateful to the College of Pharmacy, Ajman
   University, for all the necessary support to carry out the successful
   accomplishment of this project (2020-IRG-PH-09). G.M.A and PMZH are
   highly grateful to generous support from the Deanship of Scientific
   Research (DSR) at King Abdulaziz University, Jeddah, Saudi Arabia (Grant
   Number FP-93-42).
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NR 194
TC 135
Z9 139
U1 41
U2 288
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0141-8130
EI 1879-0003
J9 INT J BIOL MACROMOL
JI Int. J. Biol. Macromol.
PD MAY 1
PY 2022
VL 206
BP 567
EP 579
DI 10.1016/j.ijbiomac.2022.03.004
PG 13
WC Biochemistry & Molecular Biology; Chemistry, Applied; Polymer Science
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry; Polymer Science
GA 7S7HU
UT WOS:000910923800004
PM 35247420
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Margolis, R
   Sant, KE
AF Margolis, Rachel
   Sant, Karilyn E.
TI Associations between Exposures to Perfluoroalkyl Substances and
   Diabetes, Hyperglycemia, or Insulin Resistance: A Scoping Review
SO JOURNAL OF XENOBIOTICS
LA English
DT Review
DE perfluoroalkyl substances; PFAS; diabetes; hyperglycemia; insulin
   resistance
ID PERFLUOROOCTANOIC ACID EXPOSURE; PERSISTENT ORGANIC POLLUTANTS;
   GLUCOSE-HOMEOSTASIS; POLYFLUOROALKYL SUBSTANCES; PERFLUORINATED
   COMPOUNDS; GESTATIONAL EXPOSURE; SERUM CONCENTRATIONS; METABOLIC
   SYNDROME; OXIDATIVE STRESS; MELLITUS
AB Per- and polyfluoroalkyl substances (PFASs) are persistent environmental pollutants that are commonly found in the human body due to exposures via drinking water, surfactants used in consumer materials, and aqueous film-forming foams (AFFFs). PFAS exposure has been linked to adverse health effects such as low infant birth weights, cancer, and endocrine disruption, though increasingly studies have demonstrated that they may perturb metabolic processes and contribute to dysfunction. This scoping review summarizes the chemistry of PFAS exposure and the epidemiologic evidence for associations between exposure to per- and polyfluoroalkyl substances and the development of diabetes, hyperglycemia, and/or insulin resistance. We identified 11 studies on gestational diabetes mellitus, 3 studies on type 1 diabetes, 7 studies on type 2 diabetes, 6 studies on prediabetes or unspecified diabetes, and 15 studies on insulin resistance or glucose tolerance using the SCOPUS and PubMed databases. Approximately 24 reported positive associations, 9 negative associations, 2 non-linear associations, and 2 inverse associations, and 8 reported no associations found between PFAS and all diabetes search terms. Cumulatively, these data indicate the need for further studies to better assess these associations between PFAS exposure and diabetes.
C1 [Margolis, Rachel; Sant, Karilyn E.] San Diego State Univ, Sch Publ Hlth, San Diego, CA 92182 USA.
C3 California State University System; San Diego State University
RP Sant, KE (corresponding author), San Diego State Univ, Sch Publ Hlth, San Diego, CA 92182 USA.
EM rbmargolis@sdsu.edu; ksant@sdsu.edu
OI Sant, Karilyn/0000-0001-8565-2072
FU SDSU Summer Undergraduate Research Program; National Institutes of
   Health [K01ES031640, U54MD012397]
FX Support for R.M. was provided by the SDSU Summer Undergraduate Research
   Program. Support for K.E.S. was provided by the National Institutes of
   Health (K01ES031640 and U54MD012397).
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NR 102
TC 34
Z9 36
U1 5
U2 65
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
SN 2039-4705
EI 2039-4713
J9 J XENOBIOTICS
JI J. Xenobiotics
PD SEP
PY 2021
VL 11
IS 3
BP 115
EP 129
DI 10.3390/jox11030008
PG 15
WC Toxicology
WE Emerging Sources Citation Index (ESCI)
SC Toxicology
GA UW6HY
UT WOS:000700255600001
PM 34564296
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Hazzaa, SM
   Abd Eldaim, MA
   Fouda, AA
   Mohamed, ASE
   Soliman, MM
   Elgizawy, EI
AF Hazzaa, Suzan M.
   Abd Eldaim, Mabrouk A.
   Fouda, Amira A.
   Mohamed, Asmaa Shams El Dein
   Soliman, Mohamed Mohamed
   Elgizawy, Eman I.
TI Intermittent Fasting Ameliorated High-Fat Diet-Induced Memory Impairment
   in Rats via Reducing Oxidative Stress and Glial Fibrillary Acidic
   Protein Expression in Brain
SO NUTRIENTS
LA English
DT Article
DE high fat diet; intermittent fasting; GFAP
AB Intermittent fasting (IF) plays an important role in the protection against metabolic syndrome-induced memory defects. This study aimed to assess the protective effects of both prophylactic and curative IF against high-fat diet (HFD)-induced memory defects in rats. The control group received a normal diet; the second group received a HFD; the third group was fed a HFD for 12 weeks and subjected to IF during the last four weeks (curative IF); the fourth group was fed a HFD and subjected to IF simultaneously (prophylactic IF). A high-fat diet significantly increased body weight, serum lipids levels, malondialdehyde (MDA) concentration, glial fibrillary acidic protein (GFAP) and H score in brain tissue and altered memory performance. In addition, it significantly decreased reduced glutathione (GSH) concentration in brain tissue and viability and thickness of pyramidal and hippocampus granular cell layers. However, both types of IF significantly decreased body weight, serum lipids, GFAP protein expression and H score and MDA concentration in brain tissue, and improved memory performance, while it significantly increased GSH concentration in brain tissue, viability, and thickness of pyramidal and granular cell layers of the hippocampus. This study indicated that IF ameliorated HFD-induced memory disturbance and brain tissue damage and the prophylactic IF was more potent than curative IF.
C1 [Hazzaa, Suzan M.; Elgizawy, Eman I.] Menoufia Univ, Med Physiol Dept, Fac Med, Shibin Al Kawm 32511, Egypt.
   [Abd Eldaim, Mabrouk A.] Menoufia Univ, Dept Biochem & Chem Nutr, Fac Vet, Med, Shibin Al Kawm 32511, Egypt.
   [Fouda, Amira A.; Mohamed, Asmaa Shams El Dein] Menoufia Univ, Pathol Dept, Fac Med, Shibin Al Kawm 32511, Egypt.
   [Soliman, Mohamed Mohamed] Taif Univ, Turabah Univ Coll, Clin Lab Sci Dept, At Taif 21995, Saudi Arabia.
   [Soliman, Mohamed Mohamed] Benha Univ, Biochem Dept, Fac Vet Med, Banha 13736, Egypt.
C3 Egyptian Knowledge Bank (EKB); Menofia University; Egyptian Knowledge
   Bank (EKB); Menofia University; Egyptian Knowledge Bank (EKB); Menofia
   University; Taif University; Egyptian Knowledge Bank (EKB); Benha
   University
RP Abd Eldaim, MA (corresponding author), Menoufia Univ, Dept Biochem & Chem Nutr, Fac Vet, Med, Shibin Al Kawm 32511, Egypt.
EM suzanhazzaa@med.menofia.edu.eg; mabroukattia@vet.menofia.edu.eg;
   aamf8296@gmail.com; asmaashams@rocketmail.com; mmsoliman@tu.edu.sa;
   eman.elgizawi@med.menofia.edu.eg
RI Abd Eldaim, Mabrouk/U-4736-2019; Soliman, Mohamed/ABJ-0997-2022;
   mohamed, asmaa/ABF-3330-2021
OI Mohamed, Asmaa Shams El Dein/0000-0003-0869-6332; Abd Eldaim,
   Mabrouk/0000-0001-9842-9777; Soliman, Mohamed
   Mohamed/0000-0001-7208-7123
FU Taif University, Taif, Saudi Arabia [TURSP2020/09]
FX This study was supported by the Taif University Researchers Supporting
   Project (TURSP2020/09), Taif University, Taif, Saudi Arabia.
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NR 44
TC 8
Z9 10
U1 0
U2 7
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JAN
PY 2021
VL 13
IS 1
AR 10
DI 10.3390/nu13010010
PG 13
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA PW4KO
UT WOS:000610640200001
PM 33375195
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Küblbeck, J
   Vuorio, T
   Niskanen, J
   Fortino, V
   Braeuning, A
   Abass, K
   Rautio, A
   Hakkola, J
   Honkakoski, P
   Levonen, AL
AF Kublbeck, Jenni
   Vuorio, Taina
   Niskanen, Jonna
   Fortino, Vittorio
   Braeuning, Albert
   Abass, Khaled
   Rautio, Arja
   Hakkola, Jukka
   Honkakoski, Paavo
   Levonen, Anna-Liisa
TI The EDCMET Project: Metabolic Effects of Endocrine Disruptors
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE endocrine disruptors (EDs); nuclear receptors (NRs); metabolism;
   metabolic syndrome; obesity; risk assessment; human health; adverse
   outcome pathway (AOP); assay validation
ID MITOCHONDRIAL DYSFUNCTION; HORMONE-RECEPTORS; CHEMICALS; TOXICOGENOMICS;
   EXPOSURE; DISCOVERY; STRESS
AB Endocrine disruptors (EDs) are defined as chemicals that mimic, block, or interfere with hormones in the body's endocrine systems and have been associated with a diverse array of health issues. The concept of endocrine disruption has recently been extended to metabolic alterations that may result in diseases, such as obesity, diabetes, and fatty liver disease, and constitute an increasing health concern worldwide. However, while epidemiological and experimental data on the close association of EDs and adverse metabolic effects are mounting, predictive methods and models to evaluate the detailed mechanisms and pathways behind these observed effects are lacking, thus restricting the regulatory risk assessment of EDs. The EDCMET (Metabolic effects of Endocrine Disrupting Chemicals: novel testing METhods and adverse outcome pathways) project brings together systems toxicologists; experimental biologists with a thorough understanding of the molecular mechanisms of metabolic disease and comprehensive in vitro and in vivo methodological skills; and, ultimately, epidemiologists linking environmental exposure to adverse metabolic outcomes. During its 5-year journey, EDCMET aims to identify novel ED mechanisms of action, to generate (pre)validated test methods to assess the metabolic effects of Eds, and to predict emergent adverse biological phenotypes by following the adverse outcome pathway (AOP) paradigm.
C1 [Kublbeck, Jenni; Vuorio, Taina; Levonen, Anna-Liisa] Univ Eastern Finland, AI Virtanen Inst Mol Sci, POB 1627, FI-70210 Kuopio, Finland.
   [Kublbeck, Jenni; Niskanen, Jonna; Honkakoski, Paavo] Univ Eastern Finland, Sch Pharm, POB 1627, FI-70210 Kuopio, Finland.
   [Fortino, Vittorio] Univ Eastern Finland, Inst Biomed, POB 1627, FI-70210 Kuopio, Finland.
   [Braeuning, Albert] German Fed Inst Risk Assessment, Dept Food Safety, DE-10589 Berlin, Germany.
   [Abass, Khaled; Rautio, Arja] Univ Oulu, Fac Med, Arctic Hlth, POB 5000, FI-90014 Oulu, Finland.
   [Rautio, Arja] Univ Oulu, Univ Arctic, Thule Inst, POB 8000, FI-90014 Oulu, Finland.
   [Hakkola, Jukka] Univ Oulu, Res Unit Biomed Pharmacol & Toxicol, POB 5000, FI-90014 Oulu, Finland.
   [Honkakoski, Paavo] Univ N Carolina, Eshelman Sch Pharm, Dept Pharmacotherapy & Expt Therapeut, Chapel Hill, NC 27599 USA.
C3 University of Eastern Finland; University of Eastern Finland; University
   of Eastern Finland; Federal Institute for Risk Assessment; University of
   Oulu; University of Oulu; University of Oulu; University of North
   Carolina; University of North Carolina Chapel Hill
RP Levonen, AL (corresponding author), Univ Eastern Finland, AI Virtanen Inst Mol Sci, POB 1627, FI-70210 Kuopio, Finland.
EM jenni.kublbeck@uef.fi; taina.vuorio@uef.fi; jonna.niskanen@uef.fi;
   vittorio.fortino@uef.fi; Albert.Braeuning@bfr.bund.de;
   khaled.megahed@oulu.fi; arja.rautio@oulu.fi; jukka.hakkola@oulu.fi;
   paavo.honkakoski@uef.fi; anna-liisa.levonen@uef.fi
RI Honkakoski, Paavo/AAJ-1278-2020; Küblbeck, Jenni/ABE-3846-2021; Abass,
   khaled/N-6138-2014
OI Abass, khaled/0000-0002-1843-7644; Niskanen, Jonna/0000-0003-2917-7873;
   Levonen, Anna-Liisa/0000-0002-6575-2137; Hakkola,
   Jukka/0000-0001-5048-4363; Honkakoski, Paavo/0000-0002-4332-3577;
   Kublbeck, Jenni/0000-0002-6439-4403
FU European Union's Horizon 2020 research and innovation programme
   [825762]; H2020 Societal Challenges Programme [825762] Funding Source:
   H2020 Societal Challenges Programme
FX The EDCMET project has received funding from the European Union's
   Horizon 2020 research and innovation programme under grant agreement no.
   825762.
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NR 71
TC 29
Z9 29
U1 2
U2 14
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD APR
PY 2020
VL 21
IS 8
AR 3021
DI 10.3390/ijms21083021
PG 16
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA LR3AC
UT WOS:000535565300363
PM 32344727
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Benova, TE
   Viczenczova, C
   Bacova, BS
   Knezl, V
   Dosenko, V
   Rauchova, H
   Zeman, M
   Reiter, RJ
   Tribulova, N
AF Benova, Tamara Egan
   Viczenczova, Csilla
   Bacova, Barbara Szeiffova
   Knezl, Vladimir
   Dosenko, Victor
   Rauchova, Hana
   Zeman, Michal
   Reiter, Russel J.
   Tribulova, Narcis
TI Obesity-associated alterations in cardiac connexin-43 and PKC signaling
   are attenuated by melatonin and omega-3 fatty acids in female rats
SO MOLECULAR AND CELLULAR BIOCHEMISTRY
LA English
DT Article
DE Female rats; Sucrose diet; Adiposity; Cardiac connexin-43; Ventricular
   fibrillation; Melatonin; Omega-3 PUFA
ID CARDIOVASCULAR-DISEASE RISK; POLYUNSATURATED FATTY-ACIDS;
   PROTEIN-KINASE-C; ATRIAL-FIBRILLATION; METABOLIC SYNDROME;
   VENTRICULAR-ARRHYTHMIAS; CIRCADIAN-RHYTHMS; OXIDATIVE STRESS;
   ANTIOXIDANT; HEART
AB We aimed to explore whether specific high-sucrose intake in older female rats affects myocardial electrical coupling protein, connexin-43 (Cx43), protein kinase C (PKC) signaling, miR-1 and miR-30a expression, and susceptibility of the heart to malignant arrhythmias. Possible benefit of the supplementation with melatonin (40 mu g/ml/day) and omega-3 polyunsaturated fatty acids (Omacor, 25g/kg of rat chow) was examined as well. Results have shown that 8weeks lasting intake of 30% sucrose solution increased serum cholesterol, triglycerides, body weight, heart weight, and retroperitoneal adipose tissues. It was accompanied by downregulation of cardiac Cx43 and PKC epsilon signaling along with an upregulation of myocardial PKC and miR-30a rendering the heart prone to ventricular arrhythmias. There was a clear benefit of melatonin or omega-3 PUFA supplementation due to their antiarrhythmic effects associated with the attenuation of myocardial Cx43, PKC, and miR-30a abnormalities as well as adiposity. The potential impact of these findings may be considerable, and suggests that high-sucrose intake impairs myocardial signaling mediated by Cx43 and PKC contributing to increased susceptibility of the older obese female rat hearts to malignant arrhythmias.
C1 [Benova, Tamara Egan; Viczenczova, Csilla; Bacova, Barbara Szeiffova; Tribulova, Narcis] Slovak Acad Sci, Inst Heart Res, Ctr Expt Med, Dubravska Cesta 9, Bartislava 84104, Slovakia.
   [Knezl, Vladimir] Slovak Acad Sci, Inst Expt Pharmacol & Toxicol, Ctr Expt Med, Bratislava, Slovakia.
   [Dosenko, Victor] Bogomoletz Inst Physiol, State Key Lab Mol & Cellular Biol, Kiev, Ukraine.
   [Rauchova, Hana] Czech Acad Sci, Inst Physiol, Prague, Czech Republic.
   [Zeman, Michal] Comenius Univ, Dept Anim Physiol & Ethol, Fac Nat Sci, Bratislava, Slovakia.
   [Reiter, Russel J.] UT Hlth Sci Ctr, Dept Cellular & Struct Biol, San Antonio, TX 78229 USA.
C3 Slovak Academy of Sciences; Slovak Academy of Sciences; Institute of
   Experimental Pharmacology & Toxicology, SAS; Centre of Experimental
   Medicine, SAS; National Academy of Sciences Ukraine; A.A. Bogomoletz
   Institute of Physiology; Czech Academy of Sciences; Institute of
   Physiology of the Czech Academy of Sciences; Comenius University
   Bratislava; University of Texas System; University of Texas Health
   Science Center at San Antonio
RP Tribulova, N (corresponding author), Slovak Acad Sci, Inst Heart Res, Ctr Expt Med, Dubravska Cesta 9, Bartislava 84104, Slovakia.
EM narcisa.tribulova@savba.sk
RI Szeiffova Bacova, Barbara/ABH-2723-2021; Zeman, Michal/L-2392-2019;
   Reiter, Russel/D-3221-2009; Rauchova, Hana/B-8288-2012
OI Szeiffova Bacova, Barbara/0000-0001-8394-7459; Dosenko,
   Victor/0000-0002-6919-7724; Rauchova, Hana/0000-0002-5807-3662; Zeman,
   Michal/0000-0002-2712-6805
FU Slovak Cardiological Society [APVV-15-0119]; VEGA [2/0167/15,
   2/0076/16]; EU Structural Fund [ITMS 26230120006]
FX This work was supported by APVV-15-0119, Slovak Cardiological Society
   Grant and VEGA 2/0167/15, 2/0076/16 grants, and by EU Structural Fund
   ITMS 26230120006. Omacor was kindly provided by Dr. Branislav Obsitnik
   from Abbott laboratories, Slovakia. English editing was performed by
   Drs. Vladislava Zoldi and RJ. Reitter.
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NR 57
TC 19
Z9 21
U1 0
U2 4
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0300-8177
EI 1573-4919
J9 MOL CELL BIOCHEM
JI Mol. Cell. Biochem.
PD APR
PY 2019
VL 454
IS 1-2
BP 191
EP 202
DI 10.1007/s11010-018-3463-0
PG 12
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA HO6NG
UT WOS:000461046100017
PM 30446908
DA 2025-06-11
ER

PT J
AU Flores-Gómez, AA
   Gomez-Villalobos, MD
   Flores, G
AF Aketzalli Flores-Gomez, Alejandra
   de Jesus Gomez-Villalobos, Ma.
   Flores, Gonzalo
TI Consequences of diabetes mellitus on neuronal connectivity in limbic
   regions
SO SYNAPSE
LA English
DT Review
DE dendrites; diabetes mellitus; hippocampus; hyperglycemia; prefrontal
   cortex
ID DENDRITIC SPINE DENSITY; BLOOD-BRAIN-BARRIER; MEDIAL PREFRONTAL CORTEX;
   HIPPOCAMPAL-NEURONS; METABOLIC SYNDROME; NUCLEUS-ACCUMBENS; COGNITIVE
   DECLINE; OXIDATIVE STRESS; ANIMAL-MODELS; MORPHOLOGY
AB Diabetes mellitus (DM) is characterized by high levels of blood glucose. In recent years, its prevalence has increased, which was 422 million in the world in 2014. In elderly patients, DM is associated with deficits in memory and learning processes. The cognitive deficits lead to dementia. With the development of animal models in DM, it has been possible to better understand quantitative morphological changes in numerous neuronal structures belonging to the limbic system, such as the prefrontal cortex (PFC), the hippocampus and basolateral amygdala (BLA). These structures are in close relationship with processes of memory and learning. Several reports have demonstrated that chronic hyperglycemia reduces spinogenesis and dendritic arborization in the aforementioned regions along with a decline in memory and learning processes, especially in streptozotocin (STZ)-induced diabetic rats. In the present review, we discuss animal models, the effects of chronic hyperglycemia on dendritic morphology of limbic regions and memory and learning processes, the effect on neural transmission in these regions, the pathologic mechanisms involved, and the relevance of dendritic morphology in diabetes. All of this information can help us to have a better understanding of dementia in diabetes mellitus and propose strategies for its prevention and treatment.
C1 [Aketzalli Flores-Gomez, Alejandra] Univ Ias Amer Puebla, Dept Ciencias Salud, Med, Puebla, Mexico.
   [de Jesus Gomez-Villalobos, Ma.; Flores, Gonzalo] Benemerita Univ Autonoma Puebla, Inst Fisiol, Puebla, Mexico.
C3 Benemerita Universidad Autonoma de Puebla
RP Flores, G (corresponding author), Univ Autonoma Puebla, Lab Neuropsiquiatria, Inst Fisiol, 14 Sur 6301, Puebla 72570, Mexico.; Gomez-Villalobos, MD (corresponding author), Univ Autonoma Puebla, Lab Fisiol Cardiovasc, Inst Fisiol, 14 Sur 6301, Puebla 72570, Mexico.
EM mgomezvillalobos@aol.com; gonzaloflores56@gmail.com
RI Flores, Gonzalo/B-1807-2014
OI Flores, Gonzalo/0000-0002-4100-2104
FU PRODEP [CA-BUAP-120]; CONACYT [252808]
FX Funding for this study was provided by grants from the PRODEP
   (CA-BUAP-120) and CONACYT grant (No. 252808) to G. Flores. None of the
   funding institutions had any further role in the study design, the
   collection of data, analyses, interpretation of data, writing of the
   report or in the decision to submit the paper for publication
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NR 75
TC 20
Z9 21
U1 0
U2 16
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0887-4476
EI 1098-2396
J9 SYNAPSE
JI Synapse
PD MAR
PY 2019
VL 73
IS 3
AR e22082
DI 10.1002/syn.22082
PG 9
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA HH2IG
UT WOS:000455541600002
PM 30457679
DA 2025-06-11
ER

PT J
AU Churm, R
   Caplin, S
   Barry, J
   Davies, JS
   Stephens, JW
   Prior, SL
AF Churm, R.
   Caplin, S.
   Barry, J.
   Davies, J. S.
   Stephens, J. W.
   Prior, S. L.
TI Acyl-ghrelin mediated lipid retention and inflammation in
   obesity-related Type 2 diabetes
SO MOLECULAR AND CELLULAR ENDOCRINOLOGY
LA English
DT Article
DE Acyl-ghrelin; Type 2 diabetes; Lipid retention; Inflammation
ID INCREASED OXIDATIVE STRESS; METABOLIC SYNDROME; INSULIN-RESISTANCE;
   CIRCULATING LEVELS; ACTIVE GHRELIN; IDENTIFICATION; EXPRESSION;
   RECEPTOR; ENZYME; CELLS
AB Acyl-ghrelin has various peripheral effects including the potential role in mediating cellular lipid removal and macrophage polarization. Previous reports are contradictory as to how glycaemia and acyl-ghrelin mediates lipid retention and inflammation within individuals with Type 2 diabetes (T2D). Our aim was to explore acyl-ghrelin levels and ghrelin expression in relation to lipid and inflammatory markers within an ex vivo human model, biopsied visceral adipose tissue.
   Results indicated that acyl-ghrelin was associated with a decline in key lipid homeostasis genes ABCG1 and LXR beta i e expression. Within T2D there was also a down regulation of these genes which was independent of acylghrelin levels. Circulatory pro-inflammatory markers (IL-6 and TNF alpha) had no association with ghrelin expression nor circulating acyl-ghrelin levels. Anti-inflammatory marker (IL-10) and total antioxidant status (TAOS%) were positively associated with ghrelin expression across samples from all groups combined (total sample cohort) and specifically within the obesity sample cohorts.
   Data supported the hypothesis that hyperglycaemia and acyl-ghrelin have a regulatory role in lipid retention. Furthermore, that both acyl- and desacyl-ghrelin is responsible for a protective inflammatory response; however this response is diminished in T2D.
C1 [Churm, R.; Stephens, J. W.; Prior, S. L.] Swansea Univ, Diabet Res Grp, Grove Bldg, Swansea, W Glam, Wales.
   [Caplin, S.; Barry, J.] Morriston Hosp, Welsh Inst Metab & Obes Surg, Swansea, W Glam, Wales.
   [Davies, J. S.] Swansea Univ, Inst Life Sci 1, Mol Neurobiol Res Grp, Swansea, W Glam, Wales.
C3 Swansea University; Morriston Hospital; Swansea University
RP Churm, R (corresponding author), Swansea Univ, Diabet Res Grp, Grove Bldg, Swansea, W Glam, Wales.
EM R.Churm@swansea.ac.uk
RI Davies, Jeffrey/K-1400-2019
OI Churm, Rachel/0000-0001-9855-6282; Davies, Jeffrey/0000-0002-4234-0033
FU Health and Care Research Wales - Welsh government [HS-14-40]
FX I would like to acknowledge Health and Care Research Wales funded by the
   Welsh government (HS-14-40) for funding this work. Also, the Welsh
   Institute of Metabolic & Obesity Surgery for assisting in sample
   collection. There is no conflict of interest to declare.
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NR 38
TC 3
Z9 6
U1 0
U2 14
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0303-7207
J9 MOL CELL ENDOCRINOL
JI Mol. Cell. Endocrinol.
PD FEB 5
PY 2019
VL 481
BP 8
EP 13
DI 10.1016/j.mce.2018.11.004
PG 6
WC Cell Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Endocrinology & Metabolism
GA HF5BV
UT WOS:000454248500002
PM 30439508
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Luís, A
   Domingues, F
   Pereira, L
AF Luis, Angelo
   Domingues, Fernanda
   Pereira, Luisa
TI Association between berries intake and cardiovascular diseases risk
   factors: a systematic review with meta-analysis and trial sequential
   analysis of randomized controlled trials
SO FOOD & FUNCTION
LA English
DT Review
ID ENDOTHELIAL PROGENITOR CELLS; CRANBERRY JUICE CONSUMPTION; PLASMA
   ANTIOXIDANT CAPACITY; BLACK-RASPBERRY EXTRACT; BLOOD-PRESSURE;
   DOUBLE-BLIND; ARTERIAL STIFFNESS; OXIDATIVE STRESS; METABOLIC SYNDROME;
   VASCULAR FUNCTION
AB The main goal of this work was to clarify the effects of the consumption of berries on cardiovascular disease (CVD) risk factors by performing a systematic review according to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analysis) statement, followed by a meta-analysis and a trial sequential analysis (TSA) of randomized controlled trials (RCTs). The electronic search was conducted in PubMed, Scopus, SciELO, Web of Science and Cochrane Library between April and June 2016. To be included, RCTs had to report 1 or more of the following outcomes: total cholesterol (TC), HDL-chole-sterol (HDL), LDL-cholesterol (LDL), triglycerides (TG), blood pressure (BP), C-reactive protein (CRP), tumour necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), vascular cell adhesion molecule-1 (VCAM), intercellular adhesion molecule-1 (ICAM), glucose, insulin, apolipoprotein A-I (Apo A-I) or apolipoprotein B (Apo B). It was observed that the intake of berries reduces TC, LDL, TG, and BP while increasing the level of HDL, suggesting a beneficial effect on the control of CVDs' risk factors. Thus, the intake of berries as nutraceuticals or functional foods could be suggested for the prevention and control of CVDs.
C1 [Luis, Angelo; Domingues, Fernanda] Univ Beira Interior, Ctr Invest Ciencias Saude CICS UBI, Av Infante D Henrique, P-6200506 Covilha, Portugal.
   [Pereira, Luisa] Univ Beira Interior, Ctr Matemat & Aplicacoes CMA UBI, Rua Marques dAvila e Bolama, P-6201001 Covilha, Portugal.
C3 Universidade da Beira Interior; Universidade da Beira Interior
RP Pereira, L (corresponding author), Univ Beira Interior, Ctr Matemat & Aplicacoes CMA UBI, Rua Marques dAvila e Bolama, P-6201001 Covilha, Portugal.
EM lpereira@ubi.pt
RI Pereira, Luísa/AAI-8916-2020; Domingues, Fernanda/N-7295-2013; Luis,
   Angelo/A-8717-2014
OI Pereira, Luisa/0000-0002-9068-4607; Domingues,
   Fernanda/0000-0002-9540-0853; Luis, Angelo/0000-0003-0712-6522
FU Universidade da Beira Interior [BIPD/ICI-FC-BST-UBI 2016]; bank
   Santander/Totta [BIPD/ICI-FC-BST-UBI 2016]
FX Angelo Luis acknowledges the Post-Doc research fellowship within the
   scope of the protocol signed between Universidade da Beira Interior and
   bank Santander/Totta with the reference BIPD/ICI-FC-BST-UBI 2016.
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NR 73
TC 54
Z9 57
U1 1
U2 25
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PD FEB
PY 2018
VL 9
IS 2
BP 740
EP 757
DI 10.1039/c7fo01551h
PG 18
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA GC6GB
UT WOS:000429887000005
PM 29243749
DA 2025-06-11
ER

PT J
AU Campbell, MS
   Berrones, AJ
   Krishnakumar, IM
   Charnigo, RJ
   Westgate, PM
   Fleenor, BS
AF Campbell, Marilyn S.
   Berrones, Adam J.
   Krishnakumar, I. M.
   Charnigo, Richard J.
   Westgate, Philip M.
   Fleenor, Bradley S.
TI Responsiveness to curcumin intervention is associated with reduced
   aortic stiffness in young, obese men with higher initial stiffness
SO JOURNAL OF FUNCTIONAL FOODS
LA English
DT Article
DE Turmeric; Vascular function; Body composition; Obesity; Inflammation;
   Bioavailability
ID ELASTIC ARTERY STIFFNESS; CARDIOVASCULAR EVENTS; METABOLIC SYNDROME;
   OXIDATIVE STRESS; AEROBIC EXERCISE; ATHEROSCLEROSIS; INFLAMMATION;
   DYSFUNCTION; PREVALENCE; MECHANISMS
AB Obesity results in greater aortic stiffness assessed by carotid-femoral Pulse Wave Velocity (cfPWV), which is an independent predictor of cardiovascular (CV) events. We hypothesized that a novel curcumin formulation with enhanced bioavailability, CurQfen (R), would reduce cfPWV and inflammation in young, obese men. In the present placebo-controlled pilot study, 22 obese subjects (BMI >= 30.0 kg/m(2)) were randomized into placebo (n = 11, BMI = 33.18 +/- 3.38 kg/m(2)) and curcumin (n = 11, BMI = 33.29 +/- 3.69 kg/m(2)) supplemented groups. When CurQfen (R) was supplemented at 500 mg/day for 12 weeks, it was found that individuals who did respond to the treatment (n = 6) entered the study with higher baseline cfPWV versus those who did not respond (n = 5) (6.81 +/- 0.83 m/s v. 5.84 +/- 0.41 m/s, p = 0.045, group by time interaction). The curcumin responders also had increased plasma IL-13 concentrations (p = 0.018, 12 weeks v. baseline). These findings suggest CurQfen curcumin has potential to de-stiffen arteries in young, obese men with greater aortic stiffness. (C) 2016 Elsevier Ltd. All rights reserved.
C1 [Campbell, Marilyn S.; Berrones, Adam J.; Fleenor, Bradley S.] Univ Kentucky, Dept Kinesiol & Hlth Promot, Lexington, KY 40506 USA.
   [Charnigo, Richard J.; Westgate, Philip M.] Univ Kentucky, Dept Biostat, Lexington, KY 40536 USA.
   [Krishnakumar, I. M.] Akay Flavours & Aromat Pvt Ltd, R&D Ctr, Malayidamthuruthu PO, Cochin 683561, Kerala, India.
C3 University of Kentucky; University of Kentucky
RP Fleenor, BS (corresponding author), Univ Kentucky, 100 Seaton Bldg, Lexington, KY 40506 USA.
EM mca243@uky.edu; adam.berrones@gmail.com; krishnakumar.im@akay-group.com;
   rjcharn2@aol.com; philip.westgate@uky.edu; bradley.fleenor@uky.edu
OI Campbell, Marilyn/0000-0002-9313-0028
FU Akay Flavours & Aromatics Pvt. Ltd.; Arvle and Ellen Turner Thacker
   Research Fund; National Center for Advancing Translational Sciences,
   National Institutes of Health [UL1TR000117]
FX We would like to thank the staff in the CCTS for technical support with
   the study. We would also like to thank Drs. Mark Abel, Jody Clasey, and
   Travis Thomas for their insightful discussions and suggestions related
   to this study. This study was funded by Akay Flavours & Aromatics Pvt.
   Ltd., Arvle and Ellen Turner Thacker Research Fund, and was supported
   by, the National Center for Advancing Translational Sciences, National
   Institutes of Health, through grant number UL1TR000117. The content is
   solely the responsibility of the authors and does not necessarily
   represent the official views of the NIH.
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NR 39
TC 40
Z9 41
U1 0
U2 8
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1756-4646
J9 J FUNCT FOODS
JI J. Funct. Food.
PD FEB
PY 2017
VL 29
BP 154
EP 160
DI 10.1016/j.jff.2016.12.013
PG 7
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA EK3SN
UT WOS:000393847800018
DA 2025-06-11
ER

PT J
AU Garbacz, WG
   Lu, PP
   Miller, TM
   Poloyac, SM
   Eyre, NS
   Mayrhofer, G
   Xu, MS
   Ren, SR
   Xie, W
AF Garbacz, Wojciech G.
   Lu, Peipei
   Miller, Tricia M.
   Poloyac, Samuel M.
   Eyre, Nicholas S.
   Mayrhofer, Graham
   Xu, Meishu
   Ren, Songrong
   Xie, Wen
TI Hepatic Overexpression of CD36 Improves Glycogen Homeostasis and
   Attenuates High-Fat Diet-Induced Hepatic Steatosis and Insulin
   Resistance
SO MOLECULAR AND CELLULAR BIOLOGY
LA English
DT Article
ID LIVER-GLYCOGEN; RAT HEPATOCYTES; INDUCED HYPOGLYCEMIA;
   GLUCOSE-HOMEOSTASIS; LIPID-METABOLISM; VLDL SECRETION; MOUSE MODEL;
   PROTEIN; OBESITY; ACTIVATION
AB The common complications in obesity and type 2 diabetes include hepatic steatosis and disruption of glucose-glycogen homeostasis, leading to hyperglycemia. Fatty acid translocase (FAT/CD36), whose expression is inducible in obesity, is known for its function in fatty acid uptake. Previous work by us and others suggested that CD36 plays an important role in hepatic lipid homeostasis, but the results have been conflicting and the mechanisms were not well understood. In this study, by using CD36-overexpressing transgenic (CD36Tg) mice, we uncovered a surprising function of CD36 in regulating glycogen homeostasis. Overexpression of CD36 promoted glycogen synthesis, and as a result, CD36Tg mice were protected from fasting hypoglycemia. When challenged with a high-fat diet (HFD), CD36Tg mice showed unexpected attenuation of hepatic steatosis, increased very low-density lipoprotein (VLDL) secretion, and improved glucose tolerance and insulin sensitivity. The HFD-fed CD36Tg mice also showed decreased levels of proinflammatory hepatic prostaglandins and 20-hydroxyeicosatetraenoic acid (20-HETE), a potent vasoconstrictive and proinflammatory arachidonic acid metabolite. We propose that CD36 functions as a protective metabolic sensor in the liver under lipid overload and metabolic stress. CD36 may be explored as a valuable therapeutic target for the management of metabolic syndrome.
C1 [Garbacz, Wojciech G.; Lu, Peipei; Xu, Meishu; Ren, Songrong; Xie, Wen] Univ Pittsburgh, Ctr Pharmacogenet, Pittsburgh, PA 15260 USA.
   [Garbacz, Wojciech G.; Lu, Peipei; Miller, Tricia M.; Poloyac, Samuel M.; Xu, Meishu; Ren, Songrong; Xie, Wen] Univ Pittsburgh, Dept Pharmaceut Sci, Pittsburgh, PA 15260 USA.
   [Eyre, Nicholas S.; Mayrhofer, Graham] Univ Adelaide, Sch Biol Sci, Adelaide, SA, Australia.
   [Xie, Wen] Univ Pittsburgh, Dept Pharmacol & Chem Biol, Pittsburgh, PA 15260 USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE); University
   of Pittsburgh; Pennsylvania Commonwealth System of Higher Education
   (PCSHE); University of Pittsburgh; University of Adelaide; Pennsylvania
   Commonwealth System of Higher Education (PCSHE); University of
   Pittsburgh
RP Xie, W (corresponding author), Univ Pittsburgh, Ctr Pharmacogenet, Pittsburgh, PA 15260 USA.; Xie, W (corresponding author), Univ Pittsburgh, Dept Pharmaceut Sci, Pittsburgh, PA 15260 USA.; Xie, W (corresponding author), Univ Pittsburgh, Dept Pharmacol & Chem Biol, Pittsburgh, PA 15260 USA.
EM wex6@pitt.edu
RI lu, peipei/GQQ-4262-2022; Xie, Wen/M-1768-2016
OI Eyre, Nicholas/0000-0002-5424-7573
FU HHS \ National Institutes of Health (NIH) [DK083952, DK099232]
FX This work, including the efforts of Wen Xie, was funded by HHS vertical
   bar National Institutes of Health (NIH) (DK083952). This work, including
   the efforts of Wen Xie, was funded by HHS vertical bar National
   Institutes of Health (NIH) (DK099232).
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NR 51
TC 46
Z9 51
U1 0
U2 13
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 0270-7306
EI 1098-5549
J9 MOL CELL BIOL
JI Mol. Cell. Biol.
PD NOV
PY 2016
VL 36
IS 21
BP 2715
EP 2727
DI 10.1128/MCB.00138-16
PG 13
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA EA5MY
UT WOS:000386666100005
PM 27528620
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Soares, NP
   Campos, KKD
   Pena, KB
   Bandeira, ACB
   Talvani, A
   Silva, ME
   Bezerra, FS
AF Soares, Nicia Pedreira
   Duarte Campos, Keila Karine
   Pena, Karina Braga
   Balthar Bandeira, Ana Carla
   Talvani, Andre
   Silva, Marcelo Eustaquio
   Bezerra, Frank Silva
TI The Effects of the Combination of a Refined Carbohydrate Diet and
   Exposure to Hyperoxia in Mice
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Article
ID ADIPOSE-TISSUE DYSFUNCTION; METABOLIC SYNDROME; INSULIN-RESISTANCE;
   OXIDATIVE STRESS; INFLAMMATION; OBESITY; FAT; PATHOGENESIS; ASSOCIATION;
   ACTIVATION
AB Obesity is a multifactorial disease with genetic, social, and environmental influences. This study aims at analyzing the effects of the combination of a refined carbohydrate diet and exposure to hyperoxia on the pulmonary oxidative and inflammatory response in mice. Twenty-four mice were divided into four groups: control group (CG), hyperoxia group (HG), refined carbohydrate diet group (RCDG), and refined carbohydrate diet + hyperoxia group (RCDHG). The experimental diet was composed of 10% sugar, 45% standard diet, and 45% sweet condensed milk. For 24 hours, the HG and RCDHG were exposed to hyperoxia and the CG and RCDG to ambient air. After the exposures were completed, the animals were euthanized, and blood, bronchoalveolar lavage fluid, and lungs were collected for analyses. The HG showed higher levels of interferon-gamma in adipose tissue as compared to other groups and higher levels of interleukin-10 and tumor necrosis factor-alpha compared to the CG and RCDHG. SOD and CAT activities in the pulmonary parenchyma decreased in the RCDHG as compared to the CG. There was an increase of lipid peroxidation in the HG, RCDG, and RCDHG as compared to the CG. A refined carbohydrate diet combined with hyperoxia promoted inflammation and redox imbalance in adult mice.
C1 [Soares, Nicia Pedreira; Duarte Campos, Keila Karine; Pena, Karina Braga; Bezerra, Frank Silva] Univ Fed Ouro Preto, Ctr Res Biol Sci NUPEB, Dept Biol Sci DECBI, Lab Expt Pathophysiol LAFEx, Ouro Preto, MG, Brazil.
   [Balthar Bandeira, Ana Carla] Univ Fed Ouro Preto, LBM, Dept Biol Sci DECBI, Ctr Res Biol Sci NUPEB, Ouro Preto, MG, Brazil.
   [Talvani, Andre] Univ Fed Ouro Preto, Lab Immunobiol Inflammat LABIIN, Dept Biol Sci DECBI, Ctr Res Biol Sci NUPEB, Ouro Preto, MG, Brazil.
   [Silva, Marcelo Eustaquio] Sch Nutr, Lab Expt Nutr LABNEX, Ouro Preto, MG, Brazil.
C3 Universidade Federal de Ouro Preto; Universidade Federal de Ouro Preto;
   Universidade Federal de Ouro Preto
RP Bezerra, FS (corresponding author), Univ Fed Ouro Preto, Ctr Res Biol Sci NUPEB, Dept Biol Sci DECBI, Lab Expt Pathophysiol LAFEx, Ouro Preto, MG, Brazil.
EM franksbezerra@hotmail.com
RI Silva, Maria/JXM-0158-2024; Bezerra, Frank/AAD-1233-2019; Talvani,
   Andre/ABF-5478-2020; Stefanadis, Christodoulos/ABH-2232-2020
OI Stefanadis, Christodoulos/0000-0001-5974-6454; Talvani,
   Andre/0000-0002-6685-6229; Bezerra, Frank/0000-0002-0804-5196
FU Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES);
   Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq);
   Fundacao de Amparo a Pesquisa do Estado de Minas Gerais (FAPEMIG);
   Federal University of Ouro Preto (UFOP)
FX The authors acknowledge the financial support of the Coordenacao de
   Aperfeicoamento de Pessoal de Nivel Superior (CAPES), Conselho Nacional
   de Desenvolvimento Cientifico e Tecnologico (CNPq), Fundacao de Amparo a
   Pesquisa do Estado de Minas Gerais (FAPEMIG), and the Federal University
   of Ouro Preto (UFOP).
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NR 47
TC 9
Z9 9
U1 0
U2 5
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PY 2016
VL 2016
AR 1014928
DI 10.1155/2016/1014928
PG 11
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA EF0TK
UT WOS:000390038700001
PM 28018521
OA Green Submitted, hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Ruggiero, C
   Elks, CM
   Kruger, C
   Cleland, E
   Addison, K
   Noland, RC
   Stadler, K
AF Ruggiero, Christine
   Elks, Carrie M.
   Kruger, Claudia
   Cleland, Ellen
   Addison, Kaity
   Noland, Robert C.
   Stadler, Krisztian
TI Albumin-bound fatty acids but not albumin itself alter redox balance in
   tubular epithelial cells and induce a peroxide-mediated redox-sensitive
   apoptosis
SO AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
LA English
DT Article
DE tubular cell; albuminuria; peroxiredoxin; apoptosis; lipotoxicity
ID RENAL-FAILURE; OXIDATIVE STRESS; KIDNEY-DISEASE; PROTEINURIA;
   PEROXIREDOXIN; PROGRESSION; OBESITY; INJURY; SERUM
AB Albuminuria is associated with metabolic syndrome and diabetes. It correlates with the progression of chronic kidney disease, particularly with tubular atrophy. The fatty acid load on albumin significantly increases in obesity, presenting a proinflammatory environment to the proximal tubules. However, little is known about changes in the redox milieu during fatty acid overload and how redox-sensitive mechanisms mediate cell death. Here, we show that albumin with fatty acid impurities or conjugated with palmitate but not albumin itself compromised mitochondrial and cell viability, membrane potential and respiration. Fatty acid overload led to a redox imbalance which deactivated the antioxidant protein peroxiredoxin 2 and caused a peroxide-mediated apoptosis through the redox-sensitive pJNK/caspase-3 pathway. Transfection of tubular cells with peroxiredoxin 2 was protective and mitigated apoptosis. Mitochondrial fatty acid entry and ceramide synthesis modulators suggested that mitochondrial beta oxidation but not ceramide synthesis may modulate lipotoxic effects on tubular cell survival. These results suggest that albumin overloaded with fatty acids but not albumin itself changes the redox environment in the tubules, inducing a peroxide-mediated redox-sensitive apoptosis. Thus, mitigating circulating fatty acid levels may be an important factor in both preserving redox balance and preventing tubular cell damage in proteinuric diseases.
C1 [Ruggiero, Christine; Kruger, Claudia; Cleland, Ellen; Addison, Kaity; Stadler, Krisztian] Pennington Biomed Res Ctr, Oxidat Stress & Dis Lab, Baton Rouge, LA 70808 USA.
   [Elks, Carrie M.; Noland, Robert C.] Pennington Biomed Res Ctr, Baton Rouge, LA 70808 USA.
C3 Louisiana State University System; Louisiana State University;
   Pennington Biomedical Research Center; Louisiana State University
   System; Louisiana State University; Pennington Biomedical Research
   Center
RP Stadler, K (corresponding author), Pennington Biomed Res Ctr, Oxidat Stress & Dis Lab, 6400 Perkins Rd, Baton Rouge, LA 70808 USA.
EM krisztian.stadler@pbrc.edu
RI Noland, Robert/N-1982-2017; Elks, Carrie/N-1961-2017; Stadler,
   Krisztian/N-1992-2017
OI Noland, Robert/0000-0001-5543-3450
FU National Institutes of Health (NIH) [DK083615]; Nutrition and Obesity
   Research Center (NORC; through National Institute of Diabetes and
   Digestive and Kidney Diseases) [P30DK072476]; Pennington Foundation;
   COBRE [NIH 8 P20GM103528]; NORC center from the NIH [NIH 1P30DK072476]
FX Research in this laboratory is supported partially by National
   Institutes of Health (NIH) Grant DK083615 to K. Stadler, a pilot and
   feasibility grant from the Nutrition and Obesity Research Center (NORC;
   through P30DK072476 from National Institute of Diabetes and Digestive
   and Kidney Diseases), and the Pennington Foundation. The work utilized
   the facilities of the Cell Biology and Bioimaging Core that is supported
   in part by COBRE (NIH 8 P20GM103528) and NORC (NIH 1P30DK072476) center
   grants from the NIH.
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NR 28
TC 55
Z9 63
U1 0
U2 7
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 1931-857X
EI 1522-1466
J9 AM J PHYSIOL-RENAL
JI Am. J. Physiol.-Renal Physiol.
PD APR
PY 2014
VL 306
IS 8
BP F896
EP F906
DI 10.1152/ajprenal.00484.2013
PG 11
WC Physiology; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology; Urology & Nephrology
GA AF3KD
UT WOS:000334610000011
PM 24500687
OA Green Published
DA 2025-06-11
ER

PT J
AU Pakfetrat, M
   Malekmakan, L
   Roozbeh, J
   Haghpanah, S
AF Pakfetrat, Maryam
   Malekmakan, Leila
   Roozbeh, Jamshid
   Haghpanah, Sezaneh
TI Magnesium and its relationship to C-reactive protein among hemodialysis
   patients
SO MAGNESIUM RESEARCH
LA English
DT Article
DE C-reactive protein; hypomagnesaemia; hemodialysis; magnesium
ID PREDIALYSIS PATIENTS; METABOLIC SYNDROME; DIETARY MAGNESIUM; SERUM;
   HEMODIAFILTRATION; ATHEROSCLEROSIS; DEFICIENCY; CALCIUM
AB Hypomagnesaemia has been reported among patients undergoing hemodialysis (HD). Recently, a possible correlation between serum magnesium (Mg) and C-reactive protein (CRP) has been stressed. This correlation has been attributed to cytokine production and oxidative stress processes. In this study we aimed to determine the relationship between serum Mg and hs-CRP levels in patients undergoing HD. This is a cross sectional study based on data collected from 58 HD patients in the Sahraee Center of Shiraz, Iran in 2007. Data were analyzed by SPSS.15, using Mann-Whitney test, Pair t-test, and Pearson's correlation coefficient. A p value of less than 0.05 was considered significant. The present study included 58 HD patients (33 M and 25 F). The mean age of our patients was 51 +/- 17.5 years old. At the start of HD, 39% of our patients had hypomagnesaemia and 60% had high hs-CRP and 31% had both. There was a significant negative correlation between serum Mg and serum hs-CRP (p < 0.04). Also, in those who had hypomagnesaemia, hs-CRP was higher (p < 0.02). The results of this research support, our hypothesis that. hypomagnesaemia in pre-dialysis patients is a risk factor for sub-clinical inflammation due to hs-CRP elevation, although further studies are clearly required.
C1 [Pakfetrat, Maryam; Malekmakan, Leila; Roozbeh, Jamshid] Shiraz Univ Med Sci, Nephrourol Res Ctr, Shiraz, Iran.
   [Haghpanah, Sezaneh] Shiraz Univ Med Sci, Hlth Syst Res Dept, Shiraz, Iran.
C3 Shiraz University of Medical Science; Shiraz University of Medical
   Science
RP Malekmakan, L (corresponding author), Shiraz Univ Med Sci, Nephrourol Res Ctr, POB 71348-14336, Shiraz, Iran.
EM malekl@sums.ac.ir
RI Roozbeh, Jamshid/AAR-3525-2021; malekmakan, leila/F-2542-2014;
   Pakfetrat, Maryam/B-5219-2018; Haghpanah, Sezaneh/F-2543-2014
OI Pakfetrat, Maryam/0000-0002-8639-317X; Haghpanah,
   Sezaneh/0000-0002-8666-2106; Dehbozorgian, Forough/0000-0002-1943-8198;
   malekmakan, leila/0000-0002-3868-9523; Roozbeh,
   Jamshid/0000-0002-4268-1727
FU Shiraz Nephro-Urology Research Center of Shiraz University of Medical
   Sciences
FX This study was funded by the Shiraz Nephro-Urology Research Center of
   Shiraz University of Medical Sciences.
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Z9 20
U1 0
U2 1
PU JOHN LIBBEY EUROTEXT LTD
PI MONTROUGE
PA 127 AVE DE LA REPUBLIQUE, 92120 MONTROUGE, FRANCE
SN 0953-1424
EI 1952-4021
J9 MAGNESIUM RES
JI Magnes. Res.
PD SEP
PY 2008
VL 21
IS 3
BP 167
EP 170
DI 10.1684/mrh.2008.0145
PG 4
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 362LU
UT WOS:000260200000003
PM 19009820
DA 2025-06-11
ER

PT J
AU Spiezia, C
   Di Rosa, C
   Fintini, D
   Ferrara, P
   De Gara, L
   Khazrai, YM
AF Spiezia, Chiara
   Di Rosa, Claudia
   Fintini, Danilo
   Ferrara, Pietro
   De Gara, Laura
   Khazrai, Yeganeh Manon
TI Nutritional Approaches in Children with Overweight or Obesity and
   Hepatic Steatosis
SO NUTRIENTS
LA English
DT Review
DE NAFLD; childhood and steatosis; childhood obesity
ID NONALCOHOLIC FATTY LIVER; CARDIOVASCULAR RISK-FACTORS; LIFE-STYLE
   INTERVENTIONS; VITAMIN-D DEFICIENCY; BODY-MASS INDEX; MEDITERRANEAN
   DIET; METABOLIC SYNDROME; OXIDATIVE STRESS; GUT MICROBIOTA;
   DOCOSAHEXAENOIC ACID
AB Childhood obesity is a global public health problem. Worldwide, 41 million children under 5 years and 340 million children and adolescents between 5 and 19 years are overweight. In addition, the recent COVID-19 epidemic has further amplified this social phenomenon. Obesity is a condition associated with various comorbidities, such as nonalcoholic fatty liver disease (NAFLD). The pathophysiology of NAFLD in obesity is intricate and involves the interaction and dysregulation of several mechanisms, such as insulin resistance, cytokine signaling, and alteration of the gut microbiota. NAFLD is defined as the presence of hepatic steatosis in more than 5% of hepatocytes, evaluated by histological analysis. It can evolve from hepatic steatosis to steatohepatitis, fibrosis, cirrhosis, hepatocellular carcinoma, and end-stage liver failure. Body weight reduction through lifestyle modification remains the first-line intervention for the management of pediatric NAFLD. Indeed, studies suggest that diets low in fat and sugar and conversely rich in dietary fibers promote the improvement of metabolic parameters. This review aims to evaluate the existing relationship between obesity and NAFLD in the pediatric population and to assess the dietary patterns and nutritional supplementations that can be recommended to prevent and manage obesity and its comorbidities.
C1 [Spiezia, Chiara; Di Rosa, Claudia; De Gara, Laura; Khazrai, Yeganeh Manon] Univ Campus Biomed Roma, Dept Sci & Technol Sustainable Dev & Hlth 1, Res Unit Food Sci & Human Nutr, Via Alvaro Portillo 21, I-00128 Rome, Italy.
   [Fintini, Danilo] Bambino Gesu Pediat Hosp, Endocrinol & Diabetol Unit, IRCCS Lgo S Onofrio, I-00165 Rome, Italy.
   [Ferrara, Pietro] Fdn Policlin Univ Campus Biomed, Dept Med & Surg, Operat Res Unit Pediat, Via Alvaro Portillo, 200, I-00128 Rome, Italy.
   [Khazrai, Yeganeh Manon] Fdn Policlin Univ Campus Biomed, Operat Res Unit Nutr & Prevent, Via Alvaro Portillo, 200, I-00128 Rome, Italy.
C3 University Campus Bio-Medico - Rome Italy; IRCCS Bambino Gesu;
   Fondazione Policlinico Universitario Campus Bio-Medico; Fondazione
   Policlinico Universitario Campus Bio-Medico
RP Di Rosa, C (corresponding author), Univ Campus Biomed Roma, Dept Sci & Technol Sustainable Dev & Hlth 1, Res Unit Food Sci & Human Nutr, Via Alvaro Portillo 21, I-00128 Rome, Italy.
EM chiara.spiezia@unicampus.it; c.dirosa@unicampus.it;
   danilo.fintini@opbg.net; p.ferrara@policlinicocampus.it;
   l.degara@unicampus.it; m.khazrai@unicampus.it
RI Khazrai, Yeganeh/ABD-5854-2020; De Gara, Laura/Y-8420-2019; fintini,
   danilo/AAA-7688-2020
OI FERRARA, Pietro/0000-0001-9449-3464; Di Rosa,
   Claudia/0000-0002-5465-5657; De Gara, Laura/0000-0001-5938-7113;
   Spiezia, Chiara/0000-0002-7215-6691
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NR 157
TC 6
Z9 6
U1 6
U2 25
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD MAY 23
PY 2023
VL 15
IS 11
AR 2435
DI 10.3390/nu15112435
PG 23
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA I7RF7
UT WOS:001004715200001
PM 37299398
OA Green Published, gold
DA 2025-06-11
ER

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   Borradaile, Nica M.
TI Two-Week Isocaloric Time-Restricted Feeding Decreases Liver Inflammation
   without Significant Weight Loss in Obese Mice with Non-Alcoholic Fatty
   Liver Disease
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE NAFLD; liver; inflammation; obesity; mouse
AB Prolonged, isocaloric, time-restricted feeding (TRF) protocols can promote weight loss, improve metabolic dysregulation, and mitigate non-alcoholic fatty liver disease (NAFLD). In addition, 3-day, severe caloric restriction can improve liver metabolism and glucose homeostasis prior to significant weight loss. Thus, we hypothesized that short-term, isocaloric TRF would improve NAFLD and characteristics of metabolic syndrome in diet-induced obese male mice. After 26 weeks of ad libitum access to western diet, mice either continued feeding ad libitum or were provided with access to the same quantity of western diet for 8 h daily, over the course of two weeks. Remarkably, this short-term TRF protocol modestly decreased liver tissue inflammation in the absence of changes in body weight or epidydimal fat mass. There were no changes in hepatic lipid accumulation or other characteristics of NAFLD. We observed no changes in liver lipid metabolism-related gene expression, despite increased plasma free fatty acids and decreased plasma triglycerides in the TRF group. However, liver Grp78 and Txnip expression were decreased with TRF suggesting hepatic endoplasmic reticulum (ER) stress and activation of inflammatory pathways may have been diminished. We conclude that two-week, isocaloric TRF can potentially decrease liver inflammation, without significant weight loss or reductions in hepatic steatosis, in obese mice with NAFLD.
C1 [Wilson, Rachel B.; Zhang, Richard; Chen, Yun Jin; Peters, Kia M.; Sawyez, Cynthia G.; Sutherland, Brian G.; Patel, Krisha; Wang, Rennian; Borradaile, Nica M.] Western Univ, Schulich Sch Med & Dent, Dept Physiol & Pharmacol, London, ON N6A 5C1, Canada.
   [Kennelly, John P.; Leonard, Kelly-Ann; Jacobs, Rene L.] Univ Alberta, Dept Agr Food & Nutrit Sci, Grp Mol & Cell Biol Lipids, Edmonton, AB T6G 2R3, Canada.
   [Wang, Rennian] Western Univ, Schulich Sch Med & Dent, Dept Pathol & Lab Med, London, ON N6A 5C1, Canada.
C3 Western University (University of Western Ontario); University of
   Alberta; Western University (University of Western Ontario)
RP Borradaile, NM (corresponding author), Western Univ, Schulich Sch Med & Dent, Dept Physiol & Pharmacol, London, ON N6A 5C1, Canada.
EM rwilso89@uwo.ca; rzhang2023@meds.uwo.ca; yche922@uwo.ca;
   kpeter44@uwo.ca; csawyez@uwo.ca; bsuther2@uwo.ca; kpate253@uwo.ca;
   jkennell@ualberta.ca; kmd4@ualberta.ca; rjacobs@ualberta.ca;
   rwang@uwo.ca; nica.borradaile@schulich.uwo.ca
RI Wang, Rennian/F-5824-2013
OI Jacobs, Rene/0000-0002-5525-1355; Kennelly, John
   Paul/0000-0002-4399-3976; Borradaile, Nica/0000-0001-6677-2175
FU Canadian Institutes of Health Research [149010, 156243, 89800]; Canada
   Graduate Scholarship; Ontario Graduate Scholarship
FX This work was funded through Project Grants from the Canadian Institutes
   of Health Research to N.M.B. (149010), R.L.J. (156243), and R.W.
   (89800). R.B.W. was supported by a Canada Graduate Scholarship. K.M.P.
   was supported by an Ontario Graduate Scholarship.
CR Assini JM, 2013, J LIPID RES, V54, P711, DOI 10.1194/jlr.M032631
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NR 32
TC 18
Z9 20
U1 1
U2 10
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD DEC
PY 2020
VL 21
IS 23
AR 9156
DI 10.3390/ijms21239156
PG 14
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA PD7VK
UT WOS:000597887700001
PM 33271781
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Molina-Pintor, IB
   Rojas-García, AE
   Bernal-Hernández, YY
   Medina-Díaz, IM
   González-Arias, CA
   Barrón-Vivanco, BS
AF Molina-Pintor, Iris Betzaida
   Rojas-Garcia, Aurora Elizabeth
   Bernal-Hernandez, Yael Yvette
   Medina-Diaz, Irma Martha
   Gonzalez-Arias, Cyndia Azucena
   Barron-Vivanco, Briscia Socorro
TI Relationship between butyrylcholinesterase activity and lipid parameters
   in workers occupationally exposed to pesticides
SO ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
LA English
DT Article
DE Butyrylcholinesterase; Lipids; Biochemical parameters; Pesticide;
   Occupational exposure; Urban sprayers; Body mass index
ID LIPOPROTEIN CHOLESTEROL RATIO; RISK-FACTORS; FATTY-ACIDS; SERUM
   PSEUDOCHOLINESTERASE; COLORIMETRIC DETERMINATION; OXIDATIVE STRESS;
   GENETIC-VARIANTS; KNOCKOUT MOUSE; IN-VIVO; ASSOCIATION
AB Exposure to organophosphate pesticides (OP) has been associated with the inhibition of cholinesterase enzymatic activity, such as butyrylcholinesterase (BuChE). Changes in BuChE activity have been associated with obesity, diabetes, hyperthyroidism, and metabolic syndrome. However, few studies have evaluated the effects of pesticides on both BuChE and lipid parameters. The aim of this study was to evaluate lipid parameters in urban sprayers and their association with BuChE activity. An analytical cross-sectional study was conducted in workers exposed to pesticides. The pesticide exposures were evaluated by the measurement of urinary dialkylphosphates. BuChE activity was determined spectrophotometrically in serum, and biochemical parameters were determined at a certified laboratory. Information regarding general characteristics, lifestyle, and other aspects was obtained from a structured questionnaire. The results showed variations in glucose, cholesterol, albumin, atherogenic index, creatinine, LDL, VLDL, triglycerides, and total lipids according to the level of exposure to pesticides in individuals with overweight and obesity. Furthermore, positive correlations between BuChE activity and lipid parameters were observed; these effects were associated with the body mass index. More studies are needed in human population to better elucidate the role of BuChE in lipid metabolism.
C1 [Molina-Pintor, Iris Betzaida; Rojas-Garcia, Aurora Elizabeth; Bernal-Hernandez, Yael Yvette; Medina-Diaz, Irma Martha; Gonzalez-Arias, Cyndia Azucena; Barron-Vivanco, Briscia Socorro] Univ Autonoma Nayarit, Lab Contaminac & Toxicol Ambiental, Secretaria Invest & Posgrad, Ciudad Cultura S-N Col Fresnos, Tepic 63190, Nayarit, Mexico.
   [Molina-Pintor, Iris Betzaida] Unidad Acad Agr, Posgrad Ciencias Biol Agr, Km 9 Carretera Tep Compostela, Xalisco, Nayarit, Mexico.
RP Barrón-Vivanco, BS (corresponding author), Univ Autonoma Nayarit, Lab Contaminac & Toxicol Ambiental, Secretaria Invest & Posgrad, Ciudad Cultura S-N Col Fresnos, Tepic 63190, Nayarit, Mexico.
EM bbarron@uan.edu.mx
RI Gonzalez-Arias, Cyndia Azucena/ITV-8434-2023
OI Medina Diaz, Irma Martha/0000-0001-8923-3895
FU CONACyT [SALUD-2014-1, 233803]; Red Tematica de Toxicologia de
   Plaguicidas [271775]
FX This work was supported by CONACyT grants: SALUD-2014-1-#233803 and Red
   Tematica de Toxicologia de Plaguicidas #271775.
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NR 63
TC 7
Z9 7
U1 0
U2 11
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0944-1344
EI 1614-7499
J9 ENVIRON SCI POLLUT R
JI Environ. Sci. Pollut. Res.
PD NOV
PY 2020
VL 27
IS 31
BP 39365
EP 39374
DI 10.1007/s11356-020-08197-2
EA JUL 2020
PG 10
WC Environmental Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology
GA NV6OR
UT WOS:000546871200010
PM 32648216
DA 2025-06-11
ER

PT J
AU Zou, LL
   Yu, H
   He, Y
   Luo, LJ
   Dong, WB
   Zhang, J
   Lei, XP
   Wieg, C
AF Zou, Lile
   Yu, Huan
   He, Yuan
   Luo, Lijuan
   Dong, Wenbin
   Zhang, Jun
   Lei, Xiaoping
   Wieg, Christian
TI Associations between Neonatal Serum Bilirubin and Childhood Obesity in
   Term Infants
SO SCIENTIFIC REPORTS
LA English
DT Article
ID INCREASES INSULIN SENSITIVITY; METABOLIC SYNDROME; GILBERT-SYNDROME;
   PPAR-GAMMA; HYPERBILIRUBINEMIA; HYPERTENSION; NEWBORN; STRESS; RISK
AB Inverse correlations between serum bilirubin level and obesity had been reported in adults. We aimed to investigate the associations between neonatal hyperbilirubinemia and childhood obesity. Data was obtained from the U.S. Collaborative Perinatal Project (CPP), a multicenter study from 1959 to 1976. Data of serum biliru bin in term newborns were used to observe the association with obesity at age of 7 years. Logistic regression models were performed to calculate adjusted odds ratios (aORs) for obesity. For children from the same mother sharing similar factors, Generalized Estimating Equation (GEE) model was used to correct for intracluster correlation. Relative to newborns with total serum bilirubin (TSB) < 3 mg/dl, there are lower risks for obesity in those with 3 mg/dl <= TSB < 6 mg/dl (aOR 0.91; 95%CI 0.81, 1.02), 6 mg/dl <= TSB < 9 mg/dl (aOR 0.88; 95%CI 0.78, 0.99), 9 mg/dl <= TSB<13 mg/dl (aOR 0.83; 95%CI 0.71, 0.98). By stratifying for subtypes of bilirubin, the inverse correlations only existed in exposure to unconjugated bilirubin. By using the GEE model correcting for intracluster correlations, the results are consistent. In summary, exposure to bilirubin up to 13 mg/dl is inversely associated with obesity at the age of 7 years in term infants.
C1 [Zou, Lile] Southwest Med Univ, Dept Histol & Embryol, Luzhou, Sichuan, Peoples R China.
   [Yu, Huan; He, Yuan; Luo, Lijuan; Dong, Wenbin; Lei, Xiaoping; Wieg, Christian] Southwest Med Univ, Affiliated Hosp, Dept Neonatol, Luzhou, Sichuan, Peoples R China.
   [Zhang, Jun; Lei, Xiaoping] Shanghai Jiao Tong Univ, Sch Med, Xinhua Hosp, MOE Shanghai Key Lab Childrens Environm Hlth, Shanghai, Peoples R China.
   [Lei, Xiaoping] Birth Defects Clin Med Res Ctr Sichuan Prov, Luzhou, Sichuan, Peoples R China.
   [Lei, Xiaoping] Southwest Med Univ, Dept Perinatol, Luzhou, Sichuan, Peoples R China.
   [Wieg, Christian] Childrens Hosp Aschaffenburg, Dept Neonatol, Aschaffenburg, Germany.
C3 Southwest Medical University; Southwest Medical University; Shanghai
   Jiao Tong University; Southwest Medical University
RP Lei, XP (corresponding author), Southwest Med Univ, Affiliated Hosp, Dept Neonatol, Luzhou, Sichuan, Peoples R China.; Zhang, J; Lei, XP (corresponding author), Shanghai Jiao Tong Univ, Sch Med, Xinhua Hosp, MOE Shanghai Key Lab Childrens Environm Hlth, Shanghai, Peoples R China.; Lei, XP (corresponding author), Birth Defects Clin Med Res Ctr Sichuan Prov, Luzhou, Sichuan, Peoples R China.; Lei, XP (corresponding author), Southwest Med Univ, Dept Perinatol, Luzhou, Sichuan, Peoples R China.
EM junjimzhang@sina.com; leixiaopingde@126.com
RI Zhang, Jun/U-2902-2018; Lei, Xiaoping/JLM-6143-2023
OI Zhang, Jun/0000-0003-1706-1611
FU National Natural Science Foundation of China [NSFC 81401280]; Sichuan
   Science and Technology Program [2019YJ0696]; Research Foundation of
   Southwest Medical University [2015SX-0056]
FX This work was supported by the National Natural Science Foundation of
   China [NSFC 81401280], the Sichuan Science and Technology Program
   [2019YJ0696] and the Research Foundation of Southwest Medical University
   (http://xmgl.swmu.edu.cn/) with project number 2015SX-0056 to Xiaoping
   Lei.
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NR 34
TC 1
Z9 1
U1 1
U2 5
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD OCT 10
PY 2019
VL 9
AR 14575
DI 10.1038/s41598-019-51043-w
PG 7
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA JC8VW
UT WOS:000489555200087
PM 31601856
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Kahraman, S
   Altinova, AE
   Elgun, S
   Yalcin, MM
   Yilmaz, BA
   Ozkan, C
   Akturk, M
   Toruner, FB
AF Kahraman, Seda
   Altinova, Alev Eroglu
   Elgun, Serenay
   Yalcin, Mehmet Muhittin
   Yilmaz, Banu Aktas
   Ozkan, Cigdem
   Akturk, Mujde
   Toruner, Fusun Balos
TI Serum activities of dipeptidyl peptidase-4 and adenosine deaminase in
   polycystic ovary syndrome: association with obesity
SO GYNECOLOGICAL ENDOCRINOLOGY
LA English
DT Article
DE Adenosine deaminase; dipeptidyl peptidase-4; obesity; inflammation;
   polycystic ovary syndrome
ID OXIDATIVE STRESS MARKERS; LIPID-PEROXIDATION; METABOLIC SYNDROME;
   CELL-ACTIVATION; GLUCOSE CONTROL; HOMEOSTASIS; DPP4; CD26
AB Dipeptidyl peptidase-4 (DPP-4) plays a role in metabolic and inflammatory diseases. Increased adenosine deaminase (ADA) has been suggested to induce insulin resistance and inflammation. We measured serum DPP-4 and ADA activities. Serum ADA activity was significantly higher in PCOS group (p=.006), whereas there was no difference in serum DPP-4 activity between the groups (p>.05). When the study subjects were divided into four groups in terms of obesity; an increasing trend in serum ADA activity between the groups was observed and ADA activity was significantly higher in overweight and obese patients with PCOS than nonobese controls (p=.016), there were no significant differences between the other groups (p>.05). A positive correlation was found between ADA and BMI in the whole group (p=.022). Multivariate regression analyses revealed that significant determinants were diastolic blood pressure, ADA, and the presence of PCOS for DPP-4 (R-2=0.344, F=9.079, p<.001); the presence of PCOS and DPP-4 for ADA (R-2=0.123, F=6.302, p=.003). We demonstrated increased serum ADA activity as well as its association with obesity in PCOS, while there was no change in serum DPP-4 activity in women with PCOS.
C1 [Kahraman, Seda] Gazi Univ, Dept Internal Med, Fac Med, TR-06500 Ankara, Turkey.
   [Altinova, Alev Eroglu; Yalcin, Mehmet Muhittin; Yilmaz, Banu Aktas; Ozkan, Cigdem; Akturk, Mujde; Toruner, Fusun Balos] Gazi Univ, Dept Endocrinol & Metab, Fac Med, Ankara, Turkey.
   [Elgun, Serenay] Ankara Univ, Fac Med, Dept Med Biochem, Ankara, Turkey.
C3 Gazi University; Gazi University; Ankara University
RP Kahraman, S (corresponding author), Gazi Univ, Dept Internal Med, Fac Med, TR-06500 Ankara, Turkey.
EM sedakayacan.kahraman@gmail.com
RI Ozkan, Cigdem/AAH-3383-2019; Elgun, Serenay/AAG-9070-2020; Toruner,
   Fusun/ABC-4701-2021; kahraman, seda/KHU-2244-2024
OI kahraman, seda/0000-0002-5328-6554; ELGUN, Serenay/0000-0002-1751-090X;
   Toruner, Fusun/0000-0002-6168-937X
CR Blauschmidt S, 2017, CLIN ENDOCRINOL, V87, P741, DOI 10.1111/cen.13444
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NR 31
TC 6
Z9 7
U1 0
U2 6
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0951-3590
EI 1473-0766
J9 GYNECOL ENDOCRINOL
JI Gynecol. Endocrinol.
PD AUG 3
PY 2019
VL 35
IS 8
BP 714
EP 718
DI 10.1080/09513590.2019.1581165
PG 5
WC Endocrinology & Metabolism; Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Obstetrics & Gynecology
GA IM3NB
UT WOS:000477899300015
PM 30896318
DA 2025-06-11
ER

PT J
AU Tabatabaee, SM
   Alavian, SM
   Ghalichi, L
   Miryounesi, SM
   Mousavizadeh, K
   Jazayeri, S
   Vafa, MR
AF Tabatabaee, Seyed Mohammad
   Alavian, Seyed Moayed
   Ghalichi, Leila
   Miryounesi, Seyed Mohammad
   Mousavizadeh, Kazem
   Jazayeri, Shima
   Vafa, Mohammad Reza
TI Green Tea in Non-Alcoholic Fatty Liver Disease: A Double Blind
   Randomized Clinical Trial
SO HEPATITIS MONTHLY
LA English
DT Article
DE Green Tea; NAFLD; Iron
ID OXIDATIVE STRESS; NONCOMMUNICABLE DISEASES; LIPID-PEROXIDATION;
   METABOLIC SYNDROME; IN-VITRO; CATECHINS; POLYPHENOLS; EXTRACT; CANCER;
   BRAIN
AB Objectives: Antioxidant treatment with Iron chelating agents is one of the suggested treatments for fatty liver disease, which has become an important health problem in the recent decades. In this study the authors evaluated the general antioxidant, iron chelating, and sugar and fat absorption characteristics of green tea.
   Methods: Patients with non-alcoholic fatty liver disease were randomly assigned to 2 groups for a double blind clinical trial. Patients in the intervention group received 550 milligrams of green tea tablets daily as well as nutritional education for 3 months. The control group received the same protocol with green tea replaced with placebo tablets.
   Results: After 3 months, 45 participants (21 in the intervention and 24 in the placebo group) completed the follow-up. The change in body mass index (BMI), aspartate aminotransferase (AST), and fasting blood sugar (FBS) was significantly different between the 2 groups, while the change in total iron binding capacity (TIBC), ferritin, alanine transaminase (ALT), HOMA, and weight did not show a significant difference.
   Conclusions: The difference between the 2 groups was mainly observed in anthropometrics, liver enzyme, and metabolic indicators, although the difference might not have been highlighted due to the effectiveness of routine treatments, that both groups received.
C1 [Tabatabaee, Seyed Mohammad; Jazayeri, Shima; Vafa, Mohammad Reza] Iran Univ Med Sci, Sch Publ Hlth, Dept Nutr, Tehran, Iran.
   [Alavian, Seyed Moayed] Baqiyatallah Univ Med Sci, Baqiyatallah Res Ctr Gastroenterol & Liver Dis BR, Tehran, Iran.
   [Alavian, Seyed Moayed] Middle East Liver Dis MELD Ctr, Tehran, Iran.
   [Ghalichi, Leila] Iran Univ Med Sci, Mental Hlth Res Ctr, Tehran, Iran.
   [Miryounesi, Seyed Mohammad] Shahid Beheshti Univ Med Sci, Genom Res Ctr, Tehran, Iran.
   [Mousavizadeh, Kazem] Iran Univ Med Sci, CMRC, Tehran, Iran.
   [Mousavizadeh, Kazem] Iran Univ Med Sci, Fac Adv Technol Med, Dept Mol Med, Tehran, Iran.
C3 Iran University of Medical Sciences; Baqiyatallah University of Medical
   Sciences (BMSU); Iran University of Medical Sciences; Shahid Beheshti
   University Medical Sciences; Iran University of Medical Sciences; Iran
   University of Medical Sciences
RP Vafa, MR (corresponding author), Iran Univ Med Sci, Sch Publ Hlth, Nutr Sci, Tehran, Iran.
EM vafa.m@iums.ac.ir
RI Sadeghi, Hossein/K-4739-2017; Ghorashi, Seyed/C-1529-2016; Vafa,
   Mohammadreza/AAC-3827-2019; Jazayeri, Shima/N-8951-2013; Ghalichi,
   Leila/GRF-6024-2022
OI Jazayeri, Shima/0000-0002-6013-4209; Mousavizadeh,
   Kazem/0000-0001-9695-2337; Ghalichi, Leila/0000-0003-3690-2359;
   Miryounesi, Mohammad/0000-0003-4705-3794; Vafa,
   Mohammadreza/0000-0001-7052-8810
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NR 27
TC 25
Z9 25
U1 0
U2 12
PU KOWSAR PUBL
PI HOENSBROEK
PA PATERSWEG 22,, HOENSBROEK, LIMBURG 6431 GC, NETHERLANDS
SN 1735-143X
EI 1735-3408
J9 HEPAT MON
JI Hepat. Mon.
PD DEC
PY 2017
VL 17
IS 12
AR e14993
DI 10.5812/hepatmon.14993
PG 6
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA GB8FR
UT WOS:000429311600001
OA hybrid
DA 2025-06-11
ER

PT J
AU Braga, TT
   Forni, MF
   Correa-Costa, M
   Ramos, RN
   Barbuto, JA
   Branco, P
   Castoldi, A
   Hiyane, MI
   Davanso, MR
   Latz, E
   Franklin, BS
   Kowaltowski, AJ
   Camara, NOS
AF Braga, Tarcio Teodoro
   Forni, Maria Fernanda
   Correa-Costa, Matheus
   Ramos, Rodrigo Nalio
   Barbuto, Jose Alexandre
   Branco, Paola
   Castoldi, Angela
   Hiyane, Meire Ioshie
   Davanso, Mariana Rodrigues
   Latz, Eicke
   Franklin, Bernardo S.
   Kowaltowski, Alicia J.
   Saraiva Camara, Niels Olsen
TI Soluble Uric Acid Activates the NLRP3 Inflammasome
SO SCIENTIFIC REPORTS
LA English
DT Article
ID OXYGEN SPECIES GENERATION; INNATE IMMUNE ACTIVATION; REACTIVE OXYGEN;
   OXIDATIVE STRESS; NALP3 INFLAMMASOME; DANGER SIGNAL; OBSTRUCTIVE
   NEPHROPATHY; ENDOPLASMIC-RETICULUM; METABOLIC SYNDROME; TISSUE-INJURY
AB Uric acid is a damage-associated molecular pattern (DAMP), released from ischemic tissues and dying cells which, when crystalized, is able to activate the NLRP3 inflammasome. Soluble uric acid (sUA) is found in high concentrations in the serum of great apes, and even higher in some diseases, before the appearance of crystals. In the present study, we sought to investigate whether uric acid, in the soluble form, could also activate the NLRP3 inflammasome and induce the production of IL-1 beta. We monitored ROS, mitochondrial area and respiratory parameters from macrophages following sUA stimulus. We observed that sUA is released in a hypoxic environment and is able to induce IL-1 beta release. This process is followed by production of mitochondrial ROS, ASC speck formation and caspase-1 activation. Nlrp3(-/-) macrophages presented a protected redox state, increased maximum and reserve oxygen consumption ratio (OCR) and higher VDAC protein levels when compared to WT and Myd88(-/-) cells. Using a disease model characterized by increased sUA levels, we observed a correlation between sUA, inflammasome activation and fibrosis. These findings suggest sUA activates the NLRP3 inflammasome. We propose that future therapeutic strategies for renal fibrosis should include strategies that block sUA or inhibit its recognition by phagocytes.
C1 [Braga, Tarcio Teodoro; Correa-Costa, Matheus; Castoldi, Angela; Hiyane, Meire Ioshie; Saraiva Camara, Niels Olsen] Univ Sao Paulo, Lab Transplantat Immunobiol, Dept Immunol, Inst Biomed Sci 4, Sao Paulo, Brazil.
   [Braga, Tarcio Teodoro; Davanso, Mariana Rodrigues; Latz, Eicke; Franklin, Bernardo S.] Univ Bonn, Univ Hosp, Inst Innate Immun, Bonn, Germany.
   [Forni, Maria Fernanda; Kowaltowski, Alicia J.] Univ Sao Paulo, Inst Quim, Dept Bioquim, Sao Paulo, Brazil.
   [Ramos, Rodrigo Nalio; Barbuto, Jose Alexandre] Univ Sao Paulo, Lab Tumor Immunol, Dept Immunol, Inst Biomed Sci 4, Sao Paulo, Brazil.
   [Branco, Paola] Univ Sao Paulo, Dept Cellular Biol, Inst Biomed Sci, Sao Paulo, Brazil.
   [Latz, Eicke] Univ Massachusetts, Sch Med, Div Infect Dis & Immunol, Worcester, MA USA.
   [Latz, Eicke] German Ctr Neurodegenerat Dis, Bonn, Germany.
   [Latz, Eicke] Norwegian Univ Sci & Technol, Dept Canc Res & Mol Med, Ctr Mol Inflammat Res, Trondheim, Norway.
   [Saraiva Camara, Niels Olsen] Fed Univ Sao Paulo UNIFESP, Div Nephrol, Clin & Expt Immunol Lab, Sao Paulo, Brazil.
   [Saraiva Camara, Niels Olsen] Univ Sao Paulo, Fac Med, Renal Pathophysiol Lab LIM16, Sao Paulo, Brazil.
C3 Universidade de Sao Paulo; University of Bonn; Universidade de Sao
   Paulo; Universidade de Sao Paulo; Universidade de Sao Paulo; Institute
   Biomed Science, University Sao Paulo; University of Massachusetts
   System; University of Massachusetts Worcester; Helmholtz Association;
   German Center for Neurodegenerative Diseases (DZNE); Norwegian
   University of Science & Technology (NTNU); Universidade Federal de Sao
   Paulo (UNIFESP); Universidade de Sao Paulo
RP Braga, TT (corresponding author), Univ Sao Paulo, Lab Transplantat Immunobiol, Dept Immunol, Inst Biomed Sci 4, Sao Paulo, Brazil.; Braga, TT (corresponding author), Univ Bonn, Univ Hosp, Inst Innate Immun, Bonn, Germany.
EM tarcio.tb@gmail.com
RI Franklin, Bernardo/G-8186-2012; Barbuto, Jose/H-5299-2011; Braga,
   Tarcio/AAG-4475-2020; Castoldi, Angela/K-1889-2015; Correa-Costa,
   Matheus/B-2006-2014; Kowaltowski, Alicia/H-8698-2012; Branco,
   Paola/H-4899-2014; Forni, Maria Fernanda/N-1096-2017; Latz,
   Eicke/H-3951-2014; Nalio Ramos, Rodrigo/K-3553-2012; Braga,
   Tarcio/E-4827-2014; Olsen Saraiva Camara, Niels/AAX-3269-2020
OI Marzagao Barbuto, Jose Alexandre/0000-0001-9526-6781; Branco, Paola
   Cristina/0000-0002-0886-1222; Forni, Maria Fernanda/0000-0002-3335-9023;
   Latz, Eicke/0000-0003-1488-5666; Nalio Ramos,
   Rodrigo/0000-0003-1249-4733; Castoldi, Angela/0000-0002-8434-7989;
   Braga, Tarcio/0000-0002-2989-1076; Olsen Saraiva Camara,
   Niels/0000-0001-5436-1248
FU CNPq (Fluid Complex INCT); Sao Paulo Research Foundation (Fapesp)
   [2014/06992-8, 2012/02270-2, 2013/07937-8]
FX We would like to thank Professor Vera Calich, from the University of Sao
   Paulo-SP, for providing NLRP3<SUP>-/-</SUP> mice; Professor Joao Santana
   Silva, from University of Sao Paulo-RP, for providing
   Casp-1<SUP>-/-</SUP> and IL1R<SUP>-/-</SUP> mice; and Professor William
   Festuccia, from University of Sao Paulo-SP, for providing
   Lyz<SUP>Cre</SUP> mice. This research received funding from CNPq (Fluid
   Complex INCT) and Sao Paulo Research Foundation (Fapesp) under grant
   agreement nos 2014/06992-8, 2012/02270-2 and 2013/07937-8.
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NR 101
TC 293
Z9 310
U1 15
U2 86
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD JAN 13
PY 2017
VL 7
AR 39884
DI 10.1038/srep39884
PG 14
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA EI0JQ
UT WOS:000392160900001
PM 28084303
OA gold, Green Published
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Pérez-Gregorio, R
   Simal-Gandara, J
AF Perez-Gregorio, Rosa
   Simal-Gandara, Jesus
TI A Critical Review of Bioactive Food Components, and of their Functional
   Mechanisms, Biological Effects and Health Outcomes
SO CURRENT PHARMACEUTICAL DESIGN
LA English
DT Review
DE Bioactive food components; biomarkers; health outcomes; future
   prospects; nutraceuticals; functional enzymes
ID NUTRIENT INTAKE VALUES; METABOLIC SYNDROME; BLOOD-PRESSURE;
   NITRIC-OXIDE; OXIDATIVE STRESS; BREAST-CANCER; RISK-FACTORS; NUTRITION;
   DIET; PEPTIDES
AB Background: Eating behaviours are closely related to some medical conditions potentially leading to death such as cancer, cardiovascular disease and diabetes. Healthy eating practices, maintaining a normal weight, and regular physical activity could prevent up to 80% of coronary heart disease, 90% of type-2 diabetes and onethird of all cancers [1].
   Method: Over the last two decades, the food industry has invested much effort in research and development of healthier, more nutritious foods. These foods are frequently designated "functional" when they contain nutritional components required for healthy living or "nutraceuticals" when intended to treat or prevent disease or disorders through a variety of bioactive (e.g., antioxidant, antimicrobial, immunomodulatory, hypocholesterolaemic) functions that are performed by functional enzymes, probiotics, prebiotics, fibres, phytosterols, peptides, proteins, isoflavones, saponins or phytic acid, among other substances.
   Results: Some agricultural and industrial residues have proven to be excellent choices as raw materials for producing bioactive compounds and have been proposed as potentially safe natural sources of antimicrobials and/or antioxidants for the food industry. Functional food ingredients containing bioactive compounds could be used as plant extracts by pharmaceutical and food industries.
   Conclusion: Bioactive food components influence health outcomes.
C1 [Perez-Gregorio, Rosa] Univ Porto, Fac Ciencias, Dept Quim & Bioquim, LAQV REQUIMTE, Rua Campo Alegre 687, Oporto, Portugal.
   [Simal-Gandara, Jesus] Univ Vigo, Fac Food Sci & Technol, Dept Analyt & Food Chem, Nutr & Bromatol Grp, Ourense Campus, E-32004 Orense, Spain.
C3 Universidade do Porto; Instituto Politecnico do Porto; Universidade de
   Vigo
RP Simal-Gandara, J (corresponding author), Univ Vigo, Fac Food Sci & Technol, Dept Analyt & Food Chem, Nutr & Bromatol Grp, Ourense Campus, E-32004 Orense, Spain.
EM jsimal@uvigo.es
RI Perez Gregorio, Maria Rosa/A-3373-2014; Simal-Gandara, Jesus/A-9533-2009
OI Perez Gregorio, Maria Rosa/0000-0003-3030-5799; , IIS Galicia
   Sur/0000-0003-3812-7413; Simal-Gandara, Jesus/0000-0001-9215-9737
FU EU FEDER
FX This work was funded by EU FEDER.
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NR 97
TC 54
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PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1381-6128
EI 1873-4286
J9 CURR PHARM DESIGN
JI Curr. Pharm. Design
PY 2017
VL 23
IS 19
BP 2731
EP 2741
DI 10.2174/1381612823666170317122913
PG 11
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA FB7SY
UT WOS:000406341500004
PM 28317483
DA 2025-06-11
ER

PT J
AU Aron-Wisnewsky, J
   Clement, K
   Pépin, JL
AF Aron-Wisnewsky, Judith
   Clement, Karine
   Pepin, Jean-Louis
TI Nonalcoholic fatty liver disease and obstructive sleep apnea
SO METABOLISM-CLINICAL AND EXPERIMENTAL
LA English
DT Article
DE Obstructive sleep apnea; Chronic intermittent hypoxia; Nonalcoholic
   fatty liver disease
ID CHRONIC INTERMITTENT HYPOXIA; MORBIDLY OBESE-PATIENTS; POSITIVE AIRWAY
   PRESSURE; SERUM AMINOTRANSFERASE LEVELS; INSULIN-RESISTANCE;
   WEIGHT-LOSS; INDUCIBLE FACTOR-1-ALPHA; METABOLIC SYNDROME; SCORING
   SYSTEM; GLUCOSE-METABOLISM
AB Obstructive sleep apnea (OSA) and more importantly its hallmark, chronic intermittent hypoxia (CIH), are established factors in the pathogenesis and exacerbation of nonalcoholic fatty liver disease (NAFLD). This has been clearly demonstrated in rodent models exposed to intermittent hypoxia, and strong evidence now also exists in both paediatric and adult human populations. OSA and CIH induce insulin-resistance and dyslipidemia which are involved in NAFLD physiopathogenesis. CIH increases the expression of the hypoxia inducible transcription factor HIF1 alpha and that of downstream genes involved in lipogenesis, thereby increasing beta-oxidation and consequently exacerbating liver oxidative stress. OSA also disrupts the gut liver axis., increasing intestinal permeability and with a possible role of gut microbiota in the link between OSA and NAFLD. OSA patients should be screened for NAFLD and vice versa those with NAFLD for OSA. To date there is no evidence that treating OSA with continuous positive airway pressure (CPAP) will improve NAFLD but it might at least stabilize and slow its progression. Nevertheless, these multimorbid patients should be efficiently treated for all their metabolic co-morbidities and be encouragedto follow weight stabilization or weight loss programs and physical activity life style interventions. (C) 2016 Elsevier Inc. All rights reserved.
C1 [Aron-Wisnewsky, Judith; Clement, Karine] Assistance Pitie Salpetriere Hosp, Inst Cardiometab & Nutr, ICAN, Paris, France.
   [Aron-Wisnewsky, Judith; Clement, Karine] Univ Paris 06, Sorbonne Univ, UMR S U1166, Nutri, F-75013 Paris, France.
   [Aron-Wisnewsky, Judith; Clement, Karine] INSERM, UMR S U1166, Nutri, F-75013 Paris, France.
   [Pepin, Jean-Louis] Grenoble Alpes Univ, INSERM, U1042, Lab Hypoxia Pathophysiol HP2, F-38000 Grenoble, France.
   [Pepin, Jean-Louis] Grenoble Alpes Univ Hosp, Pole Thorax & Vaisseaux, F-38000 Grenoble, France.
C3 Assistance Publique Hopitaux Paris (APHP); Institut National de la Sante
   et de la Recherche Medicale (Inserm); Sorbonne Universite; Sorbonne
   Universite; Institut National de la Sante et de la Recherche Medicale
   (Inserm); Institut National de la Sante et de la Recherche Medicale
   (Inserm); Communaute Universite Grenoble Alpes; Universite Grenoble
   Alpes (UGA); CHU Grenoble Alpes; Communaute Universite Grenoble Alpes;
   Universite Grenoble Alpes (UGA)
RP Aron-Wisnewsky, J (corresponding author), Hop La Pitie Salpetriere, ICAN, 91 Bd Hop, F-75013 Paris 13, France.; Pépin, JL (corresponding author), CHU Grenoble, Lab EFCR, CP10217, F-38043 Grenoble 09, France.
EM judith.aron-wisnewsky@psl.aphp.fr; jpepin@chu-grenoble.fr
RI ARON-WISNEWSKY, judith/AAH-7608-2020; Clément, karine/R-1120-2017;
   PEPIN, Jean-Louis/M-6549-2014
OI Pepin, Jean Louis/0000-0003-3832-2358
FU French Endowment Fund "Agir pour les maladies chroniques"
FX This review was supported by the French Endowment Fund "Agir pour les
   maladies chroniques".
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NR 101
TC 84
Z9 87
U1 0
U2 29
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0026-0495
EI 1532-8600
J9 METABOLISM
JI Metab.-Clin. Exp.
PD AUG
PY 2016
VL 65
IS 8
BP 1124
EP 1135
DI 10.1016/j.metabol.2016.05.004
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA DR4RH
UT WOS:000379889400011
PM 27324067
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Ting, WJ
   Kuo, WW
   Hsieh, DJY
   Yeh, YL
   Day, CH
   Chen, YH
   Chen, RJ
   Padma, VV
   Chen, YH
   Huang, CY
AF Ting, Wei-Jen
   Kuo, Wei-Wen
   Hsieh, Dennis Jine-Yuan
   Yeh, Yu-Lan
   Day, Cecilia-Hsuan
   Chen, Ya-Hui
   Chen, Ray-Jade
   Padma, Viswanadha Vijaya
   Chen, Yi-Hsing
   Huang, Chih-Yang
TI Heat Killed Lactobacillus reuteri GMNL-263 Reduces Fibrosis
   Effects on the Liver and Heart in High Fat Diet-Hamsters via TGF-β
   Suppression
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE Lactobacillus reuteri GMNL-263; transforming growth factor beta;
   cardiovascular diseases
ID METABOLIC SYNDROME; CARDIAC APOPTOSIS; CHOLESTEROL ACCUMULATION;
   MORTALITY; ACTIVATION; INHIBITION; RECEPTOR; DYSFUNCTION; MICROBIOME;
   PROBIOTICS
AB Obesity is one of the major risk factors for nonalcoholic fatty liver disease (NAFLD), and NAFLD is highly associated with an increased risk of cardiovascular disease (CVD). Scholars have suggested that certain probiotics may significantly impact cardiovascular health, particularly certain Lactobacillus species, such as Lactobacillus reuteri GMNL-263 (Lr263) probiotics, which have been shown to reduce obesity and arteriosclerosis in vivo. In the present study, we examined the potential of heat-killed bacteria to attenuate high fat diet (HFD)-induced hepatic and cardiac damages and the possible underlying mechanism of the positive effects of heat-killed Lr263 oral supplements. Heat-killed Lr263 treatments (625 and 3125 mg/kg-hamster/day) were provided as a daily supplement by oral gavage to HFD-fed hamsters for eight weeks. The results show that heat-killed Lr263 treatments reduce fatty liver syndrome. Moreover, heat-killed Lactobacillus reuteri GMNL-263 supplementation in HFD hamsters also reduced fibrosis in the liver and heart by reducing transforming growth factor (TGF-) expression levels. In conclusion, heat-killed Lr263 can reduce lipid metabolic stress in HFD hamsters and decrease the risk of fatty liver and cardiovascular disease.
C1 [Ting, Wei-Jen; Huang, Chih-Yang] China Med Univ, Grad Inst Basic Med Sci, Taichung 40402, Taiwan.
   [Kuo, Wei-Wen] China Med Univ, Dept Biol Sci & Technol, Taichung 40402, Taiwan.
   [Hsieh, Dennis Jine-Yuan] Chung Shan Med Univ, Sch Med Lab & Biotechnol, Taichung 40201, Taiwan.
   [Yeh, Yu-Lan] Changhua Christian Hosp, Dept Pathol, Changhua 50006, Taiwan.
   [Yeh, Yu-Lan] Jen Teh Jr Coll Med Nursing & Management, Miaoli 35664, Taiwan.
   [Day, Cecilia-Hsuan] Mei Ho Univ, Dept Nursing, Pingtung 91201, Taiwan.
   [Chen, Ya-Hui; Chen, Yi-Hsing] GenMont Biotech Inc, Dept Res & Dev, Tainan 74144, Taiwan.
   [Chen, Ray-Jade] Taipei Med Univ, Sch Med, Dept Surg, Coll Med, Taipei 11031, Taiwan.
   [Padma, Viswanadha Vijaya] Bharathiar Univ, Dept Biotechnol, Coimbatore 641046, Tamil Nadu, India.
   [Huang, Chih-Yang] China Med Univ, Grad Inst Chinese Med Sci, Taichung 40402, Taiwan.
   [Huang, Chih-Yang] Asia Univ, Dept Hlth & Nutr Biotechnol, Taichung 41354, Taiwan.
C3 China Medical University Taiwan; China Medical University Taiwan; Chung
   Shan Medical University; Changhua Christian Hospital; Taipei Medical
   University; Bharathiar University; China Medical University Taiwan; Asia
   University Taiwan
RP Chen, YH (corresponding author), GenMont Biotech Inc, Dept Res & Dev, Tainan 74144, Taiwan.
EM Wei-Jen.Ting@outlook.com; wwkuo@mail.cmu.edu.tw; djh@csmu.edu.tw;
   1867@cch.org.tw; x00003023@meiho.edu.tw; yahui@genmont.com.tw;
   rayjchen@tmu.edu.tw; padama.vijaya@gmail.com; ethan@genmont.com.tw;
   cyhuang@mail.cmu.edu.tw
RI Yi-Hsing, Chen/AAQ-6284-2020; Chen, Ray/GRJ-6736-2022; Huang, Kevin
   Chih-Yang/Q-4862-2016
OI Huang, Chih-Yang/0000-0003-2347-0411
FU Taiwan Ministry of Health and Welfare Clinical Trial and Research Center
   of Excellence [MOHW104-TDU-B-212-113002]
FX This study is supported in part by Taiwan Ministry of Health and Welfare
   Clinical Trial and Research Center of Excellence
   (MOHW104-TDU-B-212-113002).
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NR 45
TC 47
Z9 51
U1 3
U2 31
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD OCT
PY 2015
VL 16
IS 10
BP 25881
EP 25896
DI 10.3390/ijms161025881
PG 16
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA CV4JD
UT WOS:000364232100143
PM 26516851
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Kamal, MA
   Priyamvada, S
   Anbazhagan, AN
   Jabir, NR
   Tabrez, S
   Greig, NH
AF Kamal, Mohammad A.
   Priyamvada, Shubha
   Anbazhagan, Arivarasu N.
   Jabir, Nasimudeen R.
   Tabrez, Shams
   Greig, Nigel H.
TI Linking Alzheimer's Disease and Type 2 Diabetes Mellitus via
   Aberrant Insulin Signaling and Inflammation
SO CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
LA English
DT Article
DE Alzheimer's disease; Anti-cholinesterase; Butyrylcholinesterase;
   Inflammation; Type 2 diabetes mellitus
ID GLYCATION END-PRODUCTS; GLUCAGON-LIKE PEPTIDE-1; NECROSIS-FACTOR-ALPHA;
   HUMAN SERUM BUTYRYLCHOLINESTERASE; AMYLOID PRECURSOR PROTEIN;
   GROWTH-FACTOR EXPRESSION; A-BETA LEVELS; MOUSE MODEL; METABOLIC
   SYNDROME; ANIMAL-MODELS
AB Alzheimer's disease (AD) and type 2 diabetes mellitus (T2DM) are two progressive and devastating health disorders afflicting millions of people worldwide. The probability and incidence of both have increased considerably in recent years consequent to increased longevity and population growth. Progressively more links are being continuously found between inflammation and central nervous system disorders like AD, Parkinson's disease, Huntington's disease, motor neuron disease, multiple sclerosis, stroke, traumatic brain injury and even cancers of the nervous tissue. The depth of the relationship depends on the timing and extent of anti- or pro-inflammatory gene expression. Inflammation has also been implicated in T2DM. Misfolding and fibrillization (of tissue specific and/or non-specific proteins) are features common to both AD and T2DM and are induced by as well as contribute to inflammation and stress (oxidative/glycation). This review appraises the roles of inflammation and abnormalities in the insulin signaling system as important shared features of T2DM and AD. The capacity of anti-cholinesterases in reducing the level of certain common inflammatory markers in particular if they may provide therapeutic potential to mitigate awry mechanisms leading to AD.
C1 [Kamal, Mohammad A.; Jabir, Nasimudeen R.; Tabrez, Shams] King Abdulaziz Univ, King Fahd Med Res Ctr, Fundamental & Appl Biol Grp, Metabol & Enzymol Unit, Jeddah 21589, Saudi Arabia.
   [Priyamvada, Shubha; Anbazhagan, Arivarasu N.] Univ Illinois, Dept Med, Sect Digest Dis & Nutr, Chicago, IL 60612 USA.
   [Greig, Nigel H.] NIA, Drug Design & Dev Sect, Translat Gerontol Branch, Intramural Res Program,NIH,Biomed Res Ctr, Baltimore, MD 21224 USA.
C3 King Abdulaziz University; University of Illinois System; University of
   Illinois Chicago; University of Illinois Chicago Hospital; National
   Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA)
RP Kamal, MA (corresponding author), King Abdulaziz Univ, King Fahd Med Res Ctr, Fundamental & Appl Biol Grp, Metabol & Enzymol Unit, POB 80216, Jeddah 21589, Saudi Arabia.
EM meu.fabg@hotmail.com
RI ; Kamal, Mohammad Amjad/J-2918-2014; Nasimudeen, Jabir/H-9483-2012;
   Tabrez, Shams/H-9476-2012
OI Priyamvada, Shubha/0000-0002-7241-569X; Kamal, Mohammad
   Amjad/0000-0003-0088-0565; Nasimudeen, Jabir/0000-0001-8548-7986;
   Tabrez, Shams/0000-0003-4550-415X
FU Intramural Research Program of the National Institute on Aging, National
   Institutes of Health, Baltimore, MD, USA; Section of Digestive Diseases
   and Nutrition, Department of Medicine, University of Illinois, Chicago,
   USA; deanship of scientific research at KSU [RGP-VPP-215]
FX N.G. is supported by the Intramural Research Program of the National
   Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
   SP and NAA are grateful for support by the Section of Digestive Diseases
   and Nutrition, Department of Medicine, University of Illinois, Chicago,
   USA. MAK, JNR and ST also extend their appreciation to the deanship of
   scientific research at KSU for funding the work through the research
   group project No- RGP-VPP-215.
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NR 139
TC 31
Z9 32
U1 0
U2 22
PU BENTHAM SCIENCE PUBL
PI BUSUM
PA PO BOX 294, BUSUM, 1400 AG, NETHERLANDS
SN 1871-5273
EI 1996-3181
J9 CNS NEUROL DISORD-DR
JI CNS Neurol. Disord.-Drug Targets
PY 2014
VL 13
IS 2
BP 338
EP 346
DI 10.2174/18715273113126660137
PG 9
WC Neurosciences; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pharmacology & Pharmacy
GA AN8EL
UT WOS:000340835800018
PM 24074448
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Kastelan, S
   Rabatic, JS
   Tomic, M
   Antunica, AG
   Ljubic, S
   Kastelan, H
   Novak, B
   Oreskovic, D
AF Kastelan, Snjezana
   Rabatic, Jasminka Salopek
   Tomic, Martina
   Antunica, Antonela Gverovic
   Ljubic, Spomenka
   Kastelan, Helena
   Novak, Branko
   Oreskovic, Darko
TI Body Mass Index and Retinopathy in Type 1 Diabetic Patients
SO INTERNATIONAL JOURNAL OF ENDOCRINOLOGY
LA English
DT Article
ID ENDOTHELIAL GROWTH-FACTOR; RISK-FACTORS; INTENSIVE TREATMENT; METABOLIC
   SYNDROME; OXIDATIVE STRESS; COMPLICATIONS; PREVALENCE; OBESITY;
   POPULATION; ASSOCIATION
AB Aim. To investigate whether body mass index (BMI) independently or in correlation with other risk factors is associated with diabetic retinopathy (DR) progression. Methods. The study included 176 patients with type 1 diabetes divided into three groups according to DR status: group 1 (no retinopathy; n = 86), group 2 (mild/moderate nonproliferative DR; n = 33), and group 3 (severe/very severe NPDR or proliferative DR; n = 57). Results. A significant deterioration of HbA(1)c, an increase in total cholesterol, systolic, diastolic blood pressure, and diabetic nephropathy with the progression of retinopathy were found. DR progression was correlated with diabetes duration, HbA(1)c, hypertension, total cholesterol, and the presence of nephropathy. In patients without nephropathy, statistical analyses showed that progression of retinopathy increased significantly with higher BMI (gr. 1: 24.03 +/- 3.52, gr. 2: 25.36 +/- 3.44, gr. 3: 26.93 +/- 3.24; P < 0.01). A positive correlation between BMI and a significant deterioration of HbA(1)c, an increase in cholesterol, triglycerides, and hypertension was observed. Conclusion. BMI in correlation with HbA(1)c, cholesterol, and hypertension appears to be associated with the progression of DR in type 1 diabetic patients without nephropathy. However, additional studies are required to investigate the pathogenic role of obesity and weight loss in retinal diabetic complications particularly relating to nephropathy.
C1 [Kastelan, Snjezana; Rabatic, Jasminka Salopek] Clin Hosp Dubrava, Dept Ophthalmol, Zagreb 10000, Croatia.
   [Tomic, Martina] Clin Hosp Merkur, Dept Ophthalmol, Univ Clin Vuk Vrhovac, Zagreb 10000, Croatia.
   [Antunica, Antonela Gverovic; Kastelan, Helena] Gen Hosp Dubrovnik, Dept Ophthalmol, Dubrovnik 20000, Croatia.
   [Ljubic, Spomenka; Novak, Branko] Clin Hosp Merkur, Dept Endocrinol & Metab Dis, Univ Clin Vuk Vrhovac, Zagreb 10000, Croatia.
   [Oreskovic, Darko] Univ Zagreb, Sch Med, Zagreb 10000, Croatia.
C3 University of Zagreb; University of Zagreb
RP Kastelan, S (corresponding author), Clin Hosp Dubrava, Dept Ophthalmol, Ave Gojka Suska 6, Zagreb 10000, Croatia.
EM snjezanakastelan@yahoo.com
RI Kaštelan, Snježana/M-5529-2016
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TC 12
Z9 12
U1 0
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1687-8337
EI 1687-8345
J9 INT J ENDOCRINOL
JI Int. J. Endocrinol.
PY 2014
VL 2014
AR 387919
DI 10.1155/2014/387919
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA AC1ED
UT WOS:000332236100001
PM 24696683
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Axelsson, J
AF Axelsson, Jonas
TI Obesity in chronic kidney disease: Good or bad?
SO BLOOD PURIFICATION
LA English
DT Article; Proceedings Paper
CT 10th International Conference on Dialysis
CY JAN 15-17, 2008
CL Cancun, MEXICO
DE fat tissue; glucose intolerance; cardiovascular disease; chronic kidney
   disease
ID SOLUBLE LEPTIN RECEPTORS; STAGE RENAL-DISEASE; BODY-MASS INDEX;
   INSULIN-RESISTANCE; ADIPOSE-TISSUE; SERUM LEPTIN; FAT MASS; SYMPATHETIC
   ACTIVITY; PERITONEAL-DIALYSIS; METABOLIC SYNDROME
AB Cardiovascular disease (CVD) remains the major cause of morbidity and mortality in chronic kidney disease (CKD) patients. As traditional risk factors cannot alone explain 1:he high prevalence and incidence of CVD in this high-risk population, the complex of insulin resistance, oxidative stress, and endothelial dysfunction has increasingly been studied as important non-traditional risk factors. Recent studies show that the adipose tissue is a complex organ with functions far beyond the mere storage of energy. Indeed, it has recently been shown that fat tissue secretes a number of;adipokines - including leptin, adiponectin and retinol-binding protein, as well as cytokines such as resistin, visfatin, tumor necrosis factor and interleukin-6. Adipokine serum levels are furthermore markedly elevated in CKD, likely due to a decreased renal excretion. Evidence suggests that these pluripotent signaling molecules may have multiple effects modulating insulin signaling, endothelial health and putatively CVD. As fat tissue is also a storage depot for energy, much needed in the catabolic milieu of uremia, further research is still needed to elucidate the likely complex interactions between these signaling networks, vascular health and outcome in this high-risk population. Copyright (c) 2008 S. Karger AG, Basel.
C1 Karolinska Inst, Dept Clin Sci Intervent & Technol, SE-14186 Stockholm, Sweden.
C3 Karolinska Institutet
RP Axelsson, J (corresponding author), Karolinska Inst, Dept Clin Sci Intervent & Technol, SE-14186 Stockholm, Sweden.
EM jonas.axelsson@ki.se
RI Axelsson, Jonas/A-4167-2011
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NR 68
TC 16
Z9 18
U1 0
U2 12
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0253-5068
EI 1421-9735
J9 BLOOD PURIFICAT
JI Blood Purif.
PY 2008
VL 26
IS 1
BP 23
EP 29
DI 10.1159/000110559
PG 7
WC Hematology; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Hematology; Urology & Nephrology
GA 245PV
UT WOS:000251948600005
PM 18182791
DA 2025-06-11
ER

PT J
AU Batchvarov, V
   Kaski, JC
   Parchure, N
   Dilaveris, P
   Brown, S
   Ghuran, A
   Färbom, P
   Hnatkova, K
   Camm, AJ
   Malik, M
AF Batchvarov, V
   Kaski, JC
   Parchure, N
   Dilaveris, P
   Brown, S
   Ghuran, A
   Färbom, P
   Hnatkova, K
   Camm, AJ
   Malik, M
TI Comparison between ventricular gradient and a new descriptor of the
   wavefront direction of ventricular activation and recovery
SO CLINICAL CARDIOLOGY
LA English
DT Article
DE repolarization; ventricular gradient; total R T cosine; postural
   changes; Valsalva
ID T-WAVE MORPHOLOGY; SYNDROME-X; QT DISPERSION; REPOLARIZATION;
   REPRODUCIBILITY; INTERVAL; SYSTEM; RISK
AB Background: Total R T cosine (TCRT) is a new descriptor of repolarization heterogeneity that quantifies the deviation between the directions of ventricular depolarization and repolarization. It revives the old concept of ventricular gradient (VG).
   Hypothesis: Our goal was to examine whether TCRT and VG contain nonredundant information by comparing their reaction to autonomic tests, namely, postural changes and Valsalva maneuver.
   Methods: Digital 12-lead electrocardiograms were recorded in 16 patients with cardiovascular syndrome X (SX, chest pain, exercise-induced ST-depression. normal coronary arteries, 3 men, age 60 9 years) and 40 healthy volunteers (31 men, age 33 7 years) during postural changes and Valsalva maneuver. The angle (VG(A)) [degrees] and magnitude (VG(M)) [ms.mV] of VG in reconstructed XYZ leads and TCRT (average cosine of the angles between the QRS and T vectors in mathematically reconstructed three-dimensional space) were calculated.
   Results: (mean +/- standard of the mean): In healthy subjects, VGM and TCRT decreased, whereas VGA increased in the sitting and standing compared with supine position (TCRT: 0.61 +/- 0.05, 0.47 +/- 0.06, 0.29 +/- 0.08, supine, sitting, and standing, p < 0.05) and during Phase II Valsalva (TCRT: 0.47 +/- 0.06 vs. 0.61 +/- 0.05, p < 0.01 in supine, 0.24 +/- 0.08 vs. 0.37 +/- 0.07, p < 0.01 in standing). In patients with SX, VG(M) decreased in the standing position, VG(A) did not change significantly, while TCRT decreased only in patients without T-wave abnormalities (n = 9) (TCRT in standing and supine: 0.55 +/- 0.09 vs. 0.68 +/- 0.08, p < 0.05). VG(M) increased during Valsalva in patients with SX. Total R T cosine correlated strongly with VG(A) (r = - 0.84, p < 0.00001) and, unlike VG(M), did not correlate with heart rate.
   Conclusions: Ventricular gradient and TCRT contain non-redundant information. In healthy subjects, they react sensitively to autonomic provocation. In patients with SX, their reaction is attenuated, which suggests disturbance of the autonomic control of repolarization.
C1 St George Hosp, Sch Med, Dept Cardiol Sci, London SW17 0RE, England.
C3 City St Georges, University of London
RP Batchvarov, V (corresponding author), St George Hosp, Sch Med, Dept Cardiol Sci, Cranmer Terrace, London SW17 0RE, England.
RI Malik, Marek/KCY-3775-2024; DILAVERIS, POLYCHRONIS/KYQ-9853-2024; Kaski,
   Juan Carlos/LKM-8031-2024; Hnatkova, Katerina/KBB-4561-2024; Camm,
   Alan/K-9882-2013
OI DILAVERIS, POLYCHRONIS/0000-0003-0399-4111; Malik,
   Marek/0000-0002-2904-1223; Malik, Marek/0000-0002-3792-1407
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NR 40
TC 12
Z9 13
U1 0
U2 0
PU CLINICAL CARDIOLOGY PUBL CO
PI MAHWAH
PA PO BOX 832, MAHWAH, NJ 07430-0832 USA
SN 0160-9289
J9 CLIN CARDIOL
JI Clin. Cardiol.
PD MAY
PY 2002
VL 25
IS 5
BP 230
EP 236
DI 10.1002/clc.4950250507
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 548CL
UT WOS:000175371000006
PM 12018881
OA Green Published
DA 2025-06-11
ER

PT J
AU Ong, P
   Mcchord, J
   Pereyra, VM
   Sechtem, U
   Bekeredjian, R
   Seitz, A
AF Ong, Peter
   Mcchord, Johanna
   Pereyra, Valeria Martinez
   Sechtem, Udo
   Bekeredjian, Raffi
   Seitz, Andreas
TI New avenues for the assessment of stable ischemic heart disease
SO CLINICAL RESEARCH IN CARDIOLOGY
LA English
DT Review; Early Access
DE Stable angina; Myocardial ischemia; Coronary artery spasm; Microvascular
   dysfunction; Coronary stenosis; Chronic coronary syndrome
ID CORONARY MICROVASCULAR DYSFUNCTION; CARDIAC SYNDROME-X; ARTERY-DISEASE;
   PERFUSION; ANGINA; MICROCIRCULATION
AB Myocardial ischemia is a complex condition which may result from epicardial and/or microvascular causes involving functional and structural mechanisms. These mechanisms may overlap in a given patient illustrating the difficulties for appropriate management. Assessment of myocardial ischemia can be performed using noninvasive and invasive tools. However, despite living in the era of individualized precision medicine, these tools are not yet used in a broader fashion. Emerging noninvasive techniques such as quantitative perfusion cardiac magnetic resonance imaging (CMR) and stress perfusion computed tomography (CT) or photon-counting CT techniques may contribute to new standards in the assessment of stable angina patients. Invasive evaluation of myocardial ischemia should not only focus on hemodynamically relevant epicardial disease but also involve coronary vasomotor function testing (coronary spasm, coronary flow reserve, and microvascular resistance) where appropriate. Optimal patient management will depend on accurate and comprehensive diagnostic evaluation of myocardial ischemia and development of new treatment options in the future.
C1 [Ong, Peter; Mcchord, Johanna; Pereyra, Valeria Martinez; Sechtem, Udo; Bekeredjian, Raffi; Seitz, Andreas] Robert Bosch Krankenhaus, Dept Cardiol & Angiol, Auerbachstr 110, D-70376 Stuttgart, Germany.
C3 Bosch; Robert Bosch Krankenhaus
RP Ong, P (corresponding author), Robert Bosch Krankenhaus, Dept Cardiol & Angiol, Auerbachstr 110, D-70376 Stuttgart, Germany.
EM Peter.Ong@rbk.de
RI Seitz, Andreas/ABI-6378-2020; Sechtem, Udo/ADK-6380-2022
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NR 34
TC 0
Z9 0
U1 0
U2 3
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1861-0684
EI 1861-0692
J9 CLIN RES CARDIOL
JI Clin. Res. Cardiol.
PD 2024 JUN 24
PY 2024
DI 10.1007/s00392-024-02483-6
EA JUN 2024
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA WD9Q8
UT WOS:001253053600002
PM 38913172
DA 2025-06-11
ER

PT J
AU Fourny, N
   Lan, C
   Bernard, M
   Desrois, M
AF Fourny, Natacha
   Lan, Carole
   Bernard, Monique
   Desrois, Martine
TI Male and Female Rats Have Different Physiological Response to High-Fat
   High-Sucrose Diet but Similar Myocardial Sensitivity to
   Ischemia-Reperfusion Injury
SO NUTRIENTS
LA English
DT Article
DE sex differences; prediabetes; myocardial ischemia-reperfusion injury;
   high-fat high sucrose diet; energy metabolism
ID SEX-DIFFERENCES; HIGH-CARBOHYDRATE; INSULIN-RESISTANCE;
   GENDER-DIFFERENCES; METABOLIC SYNDROME; RESONANCE-SPECTROSCOPY;
   CARDIOVASCULAR-DISEASE; OXIDATIVE STRESS; INDUCED OBESITY; LEPTIN
AB Prediabetes is a strong predictor of type 2 diabetes and its associated cardiovascular complications, but few studies explore sexual dimorphism in this context. Here, we aim to determine whether sex influences physiological response to high-fat high-sucrose diet (HFS) and myocardial tolerance to ischemia-reperfusion injury. Male and female Wistar rats were subjected to standard (CTRL) or HFS diet for 5 months. Then, ex-vivo experiments on isolated perfused heart model were performed to evaluate tolerance to ischemia-reperfusion injury. HFS diet induced fasting hyperglycemia and increased body fat percent to a similar level in both sexes. However, glucose intolerance was more pronounced in female HFS. Cholesterol was increased only in female while male displayed higher level of plasmatic leptin. We observed increased heart weight to tibia length ratio only in males, but we showed a similar decrease in tolerance to ischemia-reperfusion injury in female and male HFS compared with respective controls, characterized by impaired cardiac function, energy metabolism and coronary flow during reperfusion. In conclusion, as soon as glucose intolerance and hyperglycemia develop, we observe higher sensitivity of hearts to ischemia-reperfusion injury without difference between males and females.
C1 [Fourny, Natacha; Lan, Carole; Bernard, Monique; Desrois, Martine] Aix Marseille Univ, CRMBM, CNRS, F-13005 Marseille, France.
C3 Centre National de la Recherche Scientifique (CNRS); Aix-Marseille
   Universite
RP Fourny, N (corresponding author), Aix Marseille Univ, CRMBM, CNRS, F-13005 Marseille, France.
EM natacha.fourny@etu.univ-amu.fr; carole.lan@univ-amu.fr;
   monique.bernard@univ-amu.fr; martine.desrois@univ-amu.fr
RI BERNARD, Monique/Q-7254-2017
OI BERNARD, Monique/0000-0002-3179-8698
FU Aix-Marseille Universite, CNRS [UMR 7339]; France Life Imaging
   [ANR-1-INBS-0006]; Agence Nationale de la Recherche [ANR-14-CE17-0016];
   Fondation pour la Recherche Medicale (FRM) [DBS20140930772]; Agence
   Nationale de la Recherche (ANR) [ANR-14-CE17-0016] Funding Source:
   Agence Nationale de la Recherche (ANR)
FX This work was supported by Aix-Marseille Universite, CNRS (UMR 7339),
   and France Life Imaging (ANR-1-INBS-0006). We further acknowledge
   funding from Agence Nationale de la Recherche
   (ANR-14-CE17-0016-COFLORES) and Fondation pour la Recherche Medicale
   (FRM DBS20140930772).
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NR 63
TC 6
Z9 6
U1 1
U2 7
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD SEP
PY 2021
VL 13
IS 9
AR 2914
DI 10.3390/nu13092914
PG 14
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA UX9QL
UT WOS:000701170400001
PM 34578791
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Monfoulet, LE
   Ruskovska, T
   Ajdzanovic, V
   Havlik, J
   Vauzour, D
   Bayram, B
   Krga, I
   Corral-Jara, KF
   Kistanova, E
   Abadjieva, D
   Massaro, M
   Scoditti, E
   Deligiannidou, E
   Kontogiorgis, C
   Arola-Arnal, A
   van Schothorst, EM
   Morand, C
   Milenkovic, D
AF Monfoulet, Laurent-Emmanuel
   Ruskovska, Tatjana
   Ajdzanovic, Vladimir
   Havlik, Jaroslav
   Vauzour, David
   Bayram, Banu
   Krga, Irena
   Corral-Jara, Karla-Fabiola
   Kistanova, Elena
   Abadjieva, Desislava
   Massaro, Marika
   Scoditti, Egeria
   Deligiannidou, Eirini
   Kontogiorgis, Christos
   Arola-Arnal, Anna
   van Schothorst, Evert M.
   Morand, Christine
   Milenkovic, Dragan
TI Molecular Determinants of the Cardiometabolic Improvements of Dietary
   Flavanols Identified by an Integrative Analysis of Nutrigenomic Data
   from a Systematic Review of Animal Studies
SO MOLECULAR NUTRITION & FOOD RESEARCH
LA English
DT Review
DE animal models; cardiometabolic health; dietary intervention; flavanols;
   nutrigenomic
ID HIGH-FAT DIET; GRAPE SEED PROANTHOCYANIDINS; GREEN TEA POLYPHENOL;
   EPIGALLOCATECHIN GALLATE; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   OXIDATIVE STRESS; ADIPOSE-TISSUE; COCOA FLAVANOLS; SKELETAL-MUSCLE
AB Scope: Flavanols are important polyphenols of the human diet with extensive demonstrations of their beneficial effects on cardiometabolic health. They contribute to preserve health acting on a large range of cellular processes. The underlying mechanisms of action of flavanols are not fully understood but involve a nutrigenomic regulation. Methods and Results: To further capture how the intake of dietary flavanols results in the modulation of gene expression, nutrigenomics data in response to dietary flavanols obtained from animal models of cardiometabolic diseases have been collected and submitted to a bioinformatics analysis. This systematic analysis shows that dietary flavanols modulate a large range of genes mainly involved in endocrine function, fatty acid metabolism, and inflammation. Several regulators of the gene expression have been predicted and include transcription factors, miRNAs and epigenetic factors. Conclusion: This review highlights the complex and multilevel action of dietary flavanols contributing to their strong potential to preserve cardiometabolic health. The identification of the potential molecular mediators and of the flavanol metabolites driving the nutrigenomic response in the target organs is still a pending question which the answer will contribute to optimize the beneficial health effects of dietary bioactives.
C1 [Monfoulet, Laurent-Emmanuel; Krga, Irena; Corral-Jara, Karla-Fabiola; Morand, Christine; Milenkovic, Dragan] Univ Clermont Auvergne, UNH, INRAE, F-63000 Clermont Ferrand, France.
   [Ruskovska, Tatjana] Goce Delcev Univ, Fac Med Sci, Stip, North Macedonia.
   [Ajdzanovic, Vladimir] Univ Belgrade, Inst Biol Res Sinisa Stankovic, Natl Inst Republ Serbia, Dept Cytol, 142 Despot Stefan Blvd, Belgrade, Serbia.
   [Havlik, Jaroslav] Czech Univ Life Sci Prague, Dept Food Sci, Prague 6, Suchdol, Czech Republic.
   [Vauzour, David] Univ East Anglia, Norwich Med Sch, Dept Nutr & Prevent Med, Norwich NR4 7TJ, Norfolk, England.
   [Bayram, Banu] Univ Hlth Sci, Dept Nutr & Dietet, Istanbul, Turkey.
   [Krga, Irena] Univ Belgrade, Ctr Excellence Nutr & Metab Res, Inst Med Res, Natl Inst Republ Serbia, Belgrade, Serbia.
   [Kistanova, Elena; Abadjieva, Desislava] Bulgarian Acad Sci, Inst Biol & Immunol Reprod, Sofia, Bulgaria.
   [Massaro, Marika; Scoditti, Egeria] Natl Res Council CNR, Inst Clin Physiol, Lecce, Italy.
   [Deligiannidou, Eirini; Kontogiorgis, Christos] Democritus Univ Thrace, Dept Med, Lab Hyg & Environm Protect, Alexandroupolis 68100, Greece.
   [Arola-Arnal, Anna] Univ Rovira & Virgili, Dept Bioquim & Biotecnol, Nutrigen Res Grp, Tarragona 43007, Spain.
   [van Schothorst, Evert M.] Wageningen Univ, Human & Anim Physiol, Wageningen, Netherlands.
   [Milenkovic, Dragan] Univ Calif Davis, Sch Med, Dept Internal Med, Div Cardiovasc Med, Davis, CA 95616 USA.
C3 Universite Clermont Auvergne (UCA); INRAE; Goce Delcev University of
   Stip; University of Belgrade; Czech University of Life Sciences Prague;
   University of East Anglia; University of Health Sciences Turkey;
   University of Belgrade; Bulgarian Academy of Sciences; Consiglio
   Nazionale delle Ricerche (CNR); Istituto di Fisiologia Clinica
   (IFC-CNR); Democritus University of Thrace; Universitat Rovira i
   Virgili; Wageningen University & Research; University of California
   System; University of California Davis
RP Monfoulet, LE (corresponding author), Univ Clermont Auvergne, UNH, INRAE, F-63000 Clermont Ferrand, France.
EM laurent-emmanuel.monfoulet@inrae.fr
RI Scoditti, Egeria/J-8609-2016; Deligiannidou,
   Georgia-Eirini/AAL-6908-2021; Ruskovska, Tatjana/V-4885-2019; Massaro,
   Marika/HNI-1375-2023; Krga, Irena/AAC-4879-2020; Arola-Arnal,
   Anna/C-2087-2015; Bayram, Banu/HJI-7100-2023; VAUZOUR,
   David/C-2245-2008; Havlik, Jaroslav/F-3371-2011; Monfoulet,
   Laurent-Emmanuel/O-6508-2016; Kistanova, Elena/J-3532-2016
OI Krga, Irena/0000-0002-2073-2896; VAUZOUR, David/0000-0001-5952-8756;
   Massaro, Marika/0000-0001-6124-5077; Havlik,
   Jaroslav/0000-0003-1900-0951; Monfoulet,
   Laurent-Emmanuel/0000-0001-9836-0255; Kistanova,
   Elena/0000-0002-5239-1715; Milenkovic, Dragan/0000-0001-6353-0912
FU COST (European Cooperation in Science and Technology) [FA1403]
FX This article is based upon work from COST Action FA1403 POSITIVe
   (Interindividual variation in response to consumption of plant food
   bioactives and determinants involved) supported by COST (European
   Cooperation in Science and Technology; www.cost.eu).Anna Arola-Arnal is
   a Serra Hunter Fellow. The authors are grateful to Yoan Renaud
   (Universite Clermont Auvergne, GReD, CNRS UMR 6293, INSERM U1103,
   Clermont-Ferrand, France) for his support with HOMER Software. COST
   Action FA1403-European Cooperation in Science and Technology
   (www.cost.eu).
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NR 145
TC 10
Z9 10
U1 2
U2 26
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1613-4125
EI 1613-4133
J9 MOL NUTR FOOD RES
JI Mol. Nutr. Food Res.
PD AUG
PY 2021
VL 65
IS 16
AR 2100227
DI 10.1002/mnfr.202100227
EA JUL 2021
PG 19
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA UB7DO
UT WOS:000669025100001
PM 34048642
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Hariharan, A
   Hakeem, AR
   Radhakrishnan, S
   Reddy, MS
   Rela, M
AF Hariharan, Apurva
   Hakeem, Abdul Rahman
   Radhakrishnan, Subathra
   Reddy, Mettu Srinivas
   Rela, Mohamed
TI The Role and Therapeutic Potential of NF-kappa-B Pathway in Severe
   COVID-19 Patients
SO INFLAMMOPHARMACOLOGY
LA English
DT Review
DE COVID-19; NF-&#954; b; Cytokine storm; Therapeutic role;
   Immunomodulation; SARS; MERS
ID SIGNALING PATHWAY; OXIDATIVE STRESS; ANGIOTENSIN-II; ACTIVATION;
   INHIBITION; KINASE; INFLAMMATION; PROTEIN; COMBINATION; SARS-COV-2
AB Coronavirus disease 2019 (COVID-19) pandemic has affected health care systems worldwide. Severe presentations of COVID-19 such as severe pneumonia and acute respiratory distress syndrome (ARDS) have been associated with the post-viral activation and release of cytokine/chemokines which leads to a "cytokine storm" causing inflammatory response and destruction, mainly affecting the lungs. COVID-19 activation of transcription factor, NF-kappa B (NF-kappa B) in various cells such as macrophages of lung, liver, kidney, central nervous system, gastrointestinal system and cardiovascular system leads to production of IL-1, IL-2, IL-6, IL-12, TNF-alpha, LT-alpha, LT-beta, GM-CSF, and various chemokines. The sensitised NF-kappa B in elderly and in patients with metabolic syndrome makes this set of population susceptible to COVID-19 and their worse complications, including higher mortality. Immunomodulation at the level of NF-kappa B activation and inhibitors of NF-kappa B (I kappa B) degradation along with TNF-alpha inhibition will potentially result in a reduction in the cytokine storm and alleviate the severity of COVID-19. Inhibition of NF-kappa B pathway has a potential therapeutic role in alleviating the severe form of COVID-19.
C1 [Hakeem, Abdul Rahman; Reddy, Mettu Srinivas; Rela, Mohamed] Bharath Inst Higher Educ & Res, Inst Liver Dis & Transplantat, Dr Rela Inst & Med Ctr, Chennai, Tamil Nadu, India.
   [Hariharan, Apurva] SRM Med Coll Hosp & Res Ctr, Chennai, Tamil Nadu, India.
   [Radhakrishnan, Subathra] Natl Fdn Liver Res, Chennai, Tamil Nadu, India.
C3 Bharath Institute of Higher Education & Research; SRM Institute of
   Science & Technology Chennai
RP Rela, M (corresponding author), Bharath Inst Higher Educ & Res, Inst Liver Dis & Transplantat, Dr Rela Inst & Med Ctr, Chennai, Tamil Nadu, India.
EM mohamedrela@gmail.com
RI Hakeem, Abdul/HLQ-7358-2023
OI Hakeem, Abdul Rahman/0000-0001-7266-3848; RADHAKRISHNAN,
   SUBATHRA/0000-0003-3093-8342
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NR 89
TC 222
Z9 234
U1 5
U2 24
PU SPRINGER BASEL AG
PI BASEL
PA PICASSOPLATZ 4, BASEL, 4052, SWITZERLAND
SN 0925-4692
EI 1568-5608
J9 INFLAMMOPHARMACOLOGY
JI Inflammopharmacology
PD FEB
PY 2021
VL 29
IS 1
BP 91
EP 100
DI 10.1007/s10787-020-00773-9
EA NOV 2020
PG 10
WC Immunology; Pharmacology & Pharmacy; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Pharmacology & Pharmacy; Toxicology
GA QM1DF
UT WOS:000587276900001
PM 33159646
OA Green Published, hybrid
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Rostamtabar, M
   Esmaeilzadeh, S
   Tourani, M
   Rahmani, A
   Baee, M
   Shirafkan, F
   Saleki, K
   Mirzababayi, SS
   Ebrahimpour, S
   Nouri, HR
AF Rostamtabar, Maryam
   Esmaeilzadeh, Sedigheh
   Tourani, Mehdi
   Rahmani, Abolfazl
   Baee, Masoud
   Shirafkan, Fatemeh
   Saleki, Kiarash
   Mirzababayi, Sajedeh S.
   Ebrahimpour, Soheil
   Nouri, Hamid Reza
TI Pathophysiological roles of chronic low-grade inflammation mediators in
   polycystic ovary syndrome
SO JOURNAL OF CELLULAR PHYSIOLOGY
LA English
DT Review
DE chronic low-grade inflammation; IL-18; IL-1 beta; inflammasome;
   polycystic ovary syndrome
ID NECROSIS-FACTOR-ALPHA; KAPPA-B ACTIVATION; CHEMOATTRACTANT PROTEIN-1
   MCP-1; INSULIN-RESISTANCE; METABOLIC SYNDROME; OXIDATIVE STRESS;
   ADIPOSE-TISSUE; FOLLICULAR-FLUID; SYNDROME PCOS; PPAR-GAMMA
AB Polycystic ovary syndrome (PCOS) is the most common hormonal imbalance disease in reproductive-aged women. Its basic characteristics are ovulatory dysfunction and ovarian overproduction of androgens that lead to severe symptoms such as insulin resistance, hirsutism, infertility, and acne. Notwithstanding the disease burden, its underlying mechanisms remain unknown, and no causal therapeutic exists. In recent years, further studies showed that inflammation processes are involved in ovulation and play a key role in ovarian follicular dynamics. Visceral adipose tissue can cause inflammatory response and maintenance of the inflammation state in adipocytes by augmented production of inflammatory cytokines, monocyte chemoattractant proteins, and recruitment of the immune cell. Therefore, the PCOS can be related to a low-grade inflammation state and inflammatory markers. Investigating the inflammatory processes and mediators that contribute to the commencement and development of PCOS can be a critical step for better understanding the pathophysiology of the disease and its treatment through inhibition or control of related pathways. In the present review, we discuss the pathophysiological roles of chronic low-grade inflammation mediators including inflammasome-related cytokines, interleukin-1 beta (IL-1 beta), and IL-18 in PCOS development.
C1 [Rostamtabar, Maryam; Rahmani, Abolfazl; Baee, Masoud; Saleki, Kiarash] Babol Univ Med Sci, Student Res Comm, Babol Sar, Iran.
   [Esmaeilzadeh, Sedigheh; Nouri, Hamid Reza] Babol Univ Med Sci, Hlth Res Inst, Infertil & Reprod Hlth Res Ctr, Babol Sar, Iran.
   [Tourani, Mehdi; Shirafkan, Fatemeh; Nouri, Hamid Reza] Babol Univ Med Sci, Hlth Res Inst, Cellular & Mol Biol Res Ctr, Babol Sar, Iran.
   [Mirzababayi, Sajedeh S.] Babol Univ Med Sci, Dept Midwifery, Babol Sar, Iran.
   [Ebrahimpour, Soheil] Babol Univ Med Sci, Hlth Res Inst, Infect Dis & Trop Med Res Ctr, Babol Sar, Iran.
   [Nouri, Hamid Reza] Babol Univ Med Sci, Hlth Res Inst, Immunoregulat Res Ctr, Babol Sar, Iran.
C3 Babol University of Medical Sciences; Babol University of Medical
   Sciences; Babol University of Medical Sciences; Babol University of
   Medical Sciences; Babol University of Medical Sciences; Babol University
   of Medical Sciences
RP Nouri, HR (corresponding author), Babol Univ Med Sci, Hlth Res Inst, Cellular & Mol Biol Res Ctr, Babol Sar, Iran.
EM nourihr851@gmail.com
RI Ebrahimpour, Soheil/C-5060-2017; Nouri, Hamidreza/AAC-4699-2020;
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NR 151
TC 144
Z9 155
U1 1
U2 43
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0021-9541
EI 1097-4652
J9 J CELL PHYSIOL
JI J. Cell. Physiol.
PD FEB
PY 2021
VL 236
IS 2
BP 824
EP 838
DI 10.1002/jcp.29912
EA JUL 2020
PG 15
WC Cell Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Physiology
GA OU0IY
UT WOS:000544892300001
PM 32617971
DA 2025-06-11
ER

PT J
AU Zhang, XN
   Wu, Q
   Zhao, Y
   Aimy, A
   Yang, XB
AF Zhang, Xiangnan
   Wu, Qiu
   Zhao, Yan
   Aimy, Alim
   Yang, Xingbin
TI Consumption of post-fermented Jing-Wei Fuzhuan brick tea alleviates
   liver dysfunction and intestinal microbiota dysbiosis in high fructose
   diet-fed mice
SO RSC ADVANCES
LA English
DT Article
ID HIGH-FAT; INSULIN-RESISTANCE; METABOLIC SYNDROME; GUT-MICROBIOTA; WATER
   EXTRACT; OBESITY; ANTIOXIDANT; POLYPHENOLS; DISEASE; INJURY
AB Emerging evidence supports the health-promoting ability of a special microbial-fermented Fuzhuan brick tea. Epigallocatechin gallate was identified as a dominant flavonoid of Fuzhuan tea aqueous extract (FTE). Mice were treated with 30% high fructose (HF) water feeding alone or in combination with administration of FTE at 400 mg per kg bw for 13 weeks. FTE caused strong inhibition against the elevation of liver weight, serum enzymatic (aspartate aminotransferase, aspartate aminotransferase and alkaline phosphatase) activities and hepatic inflammatory cytokines (interleukin-1, interleukin-6, tumor necrosis factor-alpha and tumor necrosis factor-beta) formation, as well as dyslipidemia (total cholesterol, total triglyceride, low-density lipoprotein-cholesterol and high-density lipoprotein-cholesterol) in HF-fed mice (p < 0.05). Hepatic malonaldehyde formation was lowered, while superoxide dismutase and glutathione peroxidase activities were enhanced by FTE treatment, relative to HF-fed mice (p < 0.05), and histopathological evaluation confirmed the protection. As revealed by 16S rDNA gene sequencing, FTE notably increased abundance of Bacteroidetes and Lactobacillus, but reduced population of Firmicutes, Proteobacteria and Tenericutes in HF feeding mice. These findings suggest that FTE exerts a hepatoprotective effect by modifying hepatic oxidative stress, inflammatory response and gut microbiota dysfunction.
C1 [Zhang, Xiangnan; Wu, Qiu; Aimy, Alim; Yang, Xingbin] Shaanxi Normal Univ, Shaanxi Engn Lab Food Green Proc & Safety Control, Shaanxi Key Lab Hazard Factors Assessment Proc &, Coll Food Engn & Nutr Sci, Xian 710119, Shaanxi, Peoples R China.
   [Zhao, Yan] Shaanxi Normal Univ, Coll Life Sci, Key Lab, Minist Educ Med Resource & Nat Pharmaceut Chem, Xian 710119, Shaanxi, Peoples R China.
C3 Shaanxi Normal University; Shaanxi Normal University
RP Yang, XB (corresponding author), Shaanxi Normal Univ, Shaanxi Engn Lab Food Green Proc & Safety Control, Shaanxi Key Lab Hazard Factors Assessment Proc &, Coll Food Engn & Nutr Sci, Xian 710119, Shaanxi, Peoples R China.
EM xbyang@snnu.edu.cn
OI zhao, yan/0000-0002-7829-5975; Yang, xingbin/0000-0002-8039-0525
FU National Natural Science Foundation of China [C31671823, C31871752]; Key
   Research and Development Plan in Shaanxi Province [2017NY-102];
   Fundamental Research Funds for the Central Universities of Shaanxi
   Normal University, China [GK201803074]; Development Program for
   Innovative Research Team of Shaanxi Normal University, China
   [GK201801002]
FX This study was supported by the National Natural Science Foundation of
   China (C31671823 and C31871752), the Key Research and Development Plan
   in Shaanxi Province (2017NY-102), the Fundamental Research Funds for the
   Central Universities of Shaanxi Normal University, China (GK201803074),
   and the Development Program for Innovative Research Team of Shaanxi
   Normal University, China (GK201801002). We acknowledge Xi'an Kangfang
   Food Co., Ltd., China for supply of Jing-Wei Fuzhuan tea materials.
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NR 61
TC 21
Z9 22
U1 0
U2 60
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2046-2069
J9 RSC ADV
JI RSC Adv.
PD JUN 3
PY 2019
VL 9
IS 30
BP 17501
EP 17513
DI 10.1039/c9ra02473e
PG 13
WC Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry
GA ID8DJ
UT WOS:000471912700064
PM 35519894
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Firneisz, G
AF Firneisz, Gabor
TI Non-alcoholic fatty liver disease and type 2 diabetes mellitus: The
   liver disease of our age?
SO WORLD JOURNAL OF GASTROENTEROLOGY
LA English
DT Article
DE Non-alcoholic fatty liver disease; Non-alcoholic steatohepatitis; Liver
   cirrhosis; Hepatocellular cancer; Dysfunctional adipose tissue; Type 2
   diabetes mellitus; Insulin resistance; Obesity; Genetics; Therapy
ID GLUCAGON-LIKE PEPTIDE-1; ENDOPLASMIC-RETICULUM STRESS; HEPATIC
   INSULIN-RESISTANCE; VITAMIN-E SUPPLEMENTATION; DE-NOVO LIPOGENESIS;
   ADIPOSE-TISSUE; DIPEPTIDYL PEPTIDASE-4; GENE-EXPRESSION; UNITED-STATES;
   RISK-FACTORS
AB Non-alcoholic fatty liver disease (NAFLD) is a chronic liver disease that might affect up to one-third of the adult population in industrialised countries. NAFLD incorporates histologically and clinically different non-alcoholic entities; fatty liver (NAFL, steatosis hepatis) and steatohepatitis (NASH-characterised by hepatocyte ballooning and lobular inflammation +/- fibrosis) might progress to cirrhosis and rarely to hepatocellular cancer. NAFL increasingly affects children (paediatric prevalence is 4.2%-9.6%). Type 2 diabetes mellitus (T2DM), insulin resistance (IR), obesity, metabolic syndrome and NAFLD are particularly closely related. Increased hepatic lipid storage is an early abnormality in insulin resistant women with a history of gestational diabetes mellitus. The accumulation of triacylglycerols in hepatocytes is predominantly derived from the plasma nonesterified fatty acid pool supplied largely by the adipose tissue. A few NAFLD susceptibility gene variants are associated with progressive liver disease, IR, T2DM and a higher risk for hepatocellular carcinoma. Although not approved, pharmacological approaches might be considered in NASH patients. (C) 2014 Baishideng Publishing Group Inc. All rights reserved.
C1 Semmelweis Univ, Dept Internal Med 2, H-1085 Budapest, Hungary.
C3 Semmelweis University
RP Firneisz, G (corresponding author), Semmelweis Univ, Dept Internal Med 2, Szentkiralyi St 46, H-1085 Budapest, Hungary.
EM firneisz.gabor@med.semmelweis-univ.hu
RI Firneisz, Gabor/AAC-9654-2021
OI Firneisz, Gabor/0000-0002-9123-8131
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NR 143
TC 124
Z9 136
U1 0
U2 38
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 8226 REGENCY DR, PLEASANTON, CA 94588 USA
SN 1007-9327
EI 2219-2840
J9 WORLD J GASTROENTERO
JI World J. Gastroenterol.
PD JUL 21
PY 2014
VL 20
IS 27
BP 9072
EP 9089
DI 10.3748/wjg.v20.i27.9072
PG 18
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA AL8LG
UT WOS:000339389600031
PM 25083080
DA 2025-06-11
ER

PT J
AU Zhu, YL
   Zhou, JH
   Ao, RG
   Yu, BQ
AF Zhu, Yalong
   Zhou, Jianhua
   Ao, Rongguang
   Yu, Baoqing
TI A-769662 Protects Osteoblasts from Hydrogen Dioxide-Induced Apoptosis
   through Activating of AMP-Activated Protein Kinase (AMPK)
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE osteonecrosis; AMPK; A-769662; oxidative stress and apoptosis
ID CELL-DEATH; THERAPEUTIC TARGET; METABOLIC SYNDROME; GROWTH-INHIBITION;
   SIGNALING PATHWAY; CANCER CELLS; AUTOPHAGY; SURVIVAL; PHOSPHORYLATION;
   NEUROBLASTOMA
AB Here we report that 5'-monophosphate (AMP)-activated protein kinase (AMPK) agonist A-769662 inhibited hydrogen peroxide (H2O2)-induced viability loss and apoptosis of human and mouse osteoblast cells. H2O2-induced moderate AMPK activation in osteoblast cells, which was enhanced by A-769662. Inactivation of AMPK by its inhibitor compound C, or by target shRNA-mediated silencing and kinase dead (KD) mutation exacerbated H2O2-induced cytotoxicity in osteoblast cells. A-769662-mediated protective effect against H2O2 was also blocked by AMPK inhibition or depletion. A-769662 inhibited reactive oxygen species (ROS) accumulation by H2O2 in osteoblast cells. Meanwhile, H2O2-induced ATP depletion was inhibited by A-769662, but was aggravated by compound C. Further, H2O2 induced AMPK-dependent and pro-survival autophagy in cultured osteoblast cells, which was enhanced by A-769662. Our results suggested that activation of AMPK by H2O2 is anti-apoptosis and pro-survival in osteoblast cells, probably due to its anti-oxidant, pro-autophagy and ATP preservation abilities, and A-769662-mediated cell-protective effect in osteoblast cells requires AMPK activation. Our study suggests that A-769662 might be further investigated as a novel anti-osteonecrosis agent.
C1 [Zhu, Yalong; Zhou, Jianhua; Ao, Rongguang; Yu, Baoqing] Fudan Univ, Shanghai Pudong Hosp, Dept Orthoped, Pudong Med Ctr, Shanghai 201399, Peoples R China.
C3 Fudan University
RP Yu, BQ (corresponding author), Fudan Univ, Shanghai Pudong Hosp, Dept Orthoped, Pudong Med Ctr, Shanghai 201399, Peoples R China.
EM pdzhuzhu@hotmail.com; jianhuazhou126@126.com; doctorybq@163.com;
   doctorybqshanghai@163.com
RI You, Baiqiang/T-2438-2019
FU National Science Foundation of China
FX This work is supported by the National Science Foundation of China.
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NR 32
TC 32
Z9 40
U1 0
U2 18
PU MDPI AG
PI BASEL
PA POSTFACH, CH-4005 BASEL, SWITZERLAND
SN 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD JUN
PY 2014
VL 15
IS 6
BP 11190
EP 11203
DI 10.3390/ijms150611190
PG 14
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA AK7WS
UT WOS:000338639000120
PM 24960362
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Jenkins, AJ
   Fu, DX
   Azar, M
   Stoner, JA
   Kaufman, DG
   Zhang, S
   Klein, RL
   Lopes-Virella, MF
   Ma, JX
   Lyons, TJ
AF Jenkins, Alicia J.
   Fu, Dongxu
   Azar, Madona
   Stoner, Julie A.
   Kaufman, Derrick G.
   Zhang, Sarah
   Klein, Richard L.
   Lopes-Virella, Maria F.
   Ma, Jian-xing
   Lyons, Timothy J.
CA VADT Investigators
TI Clinical correlates of serum pigment epithelium-derived factor in type 2
   diabetes patients
SO JOURNAL OF DIABETES AND ITS COMPLICATIONS
LA English
DT Article
DE PEDF; Type 2 diabetes; Cardio-vascular risk factors
ID ADIPOSE TRIGLYCERIDE LIPASE; FACTOR PEDF; INSULIN-RESISTANCE; METABOLIC
   SYNDROME; VASCULAR COMPLICATIONS; OXIDATIVE STRESS; RETINOPATHY;
   INFLAMMATION; NEPHROPATHY; MARKER
AB Aim: To determine if serum pigment epithelium-derived factor (PEDF) levels in Type 2 diabetes are related to vascular risk factors and renal function.
   Methods: PEDF was quantified by ELISA in a cross-sectional study of 857 male Veterans Affairs Diabetes Trial (VADT) subjects, and associations with cardiovascular risk factors and renal function were determined. In a subset (n = 246) in whom serum was obtained early in the VADT (2.0 +/- 0.3 years post-randomization), PEDF was related to longitudinal changes in renal function over 3.1 years
   Results: Cross-sectional study: In multivariate regression models, PEDF was positively associated with serum triglycerides, waist-to-hip ratio, serum creatinine, use of ACE inhibitors or angiotensin receptor blockers, and use of lipid-lowering agents; it was negatively associated with HDL-C (all p < 0.05).
   Longitudinal study: PEDF was not associated with changes in renal function over 3.1 years (p > 0.09).
   Conclusions: Serum PEDF in Type 2 diabetic men was cross-sectionally associated with dyslipidemia, body habitus, use of common drugs for blood pressure and dyslipidemia, and indices of renal function; however, PEDF was not associated with renal decline over 3.1 years. (C) 2014 Elsevier Inc. All rights reserved.
C1 [Jenkins, Alicia J.; Fu, Dongxu; Lyons, Timothy J.] Queens Univ Belfast, Ctr Med Expt, Belfast BT12 6BA, Antrim, North Ireland.
   [Jenkins, Alicia J.] Univ Sydney, NHMRC Clin Trials Ctr, Sydney, NSW 2006, Australia.
   [Azar, Madona; Zhang, Sarah; Lyons, Timothy J.] Univ Oklahoma, Hlth Sci Ctr, Sect Endocrinol & Diabet, Oklahoma City, OK USA.
   [Stoner, Julie A.] Univ Oklahoma, Hlth Sci Ctr, Coll Publ Hlth, Oklahoma City, OK USA.
   [Kaufman, Derrick G.] Edward Hines Jr VA Hosp, Hines VA Cooperat Studies Program CSP Coordinat, Hines, IL USA.
   [Zhang, Sarah] SUNY Buffalo, Ross Eye Inst, Dept Ophthalmol, Buffalo, NY 14260 USA.
   [Klein, Richard L.; Lopes-Virella, Maria F.] Med Univ S Carolina, Div Endocrinol, Charleston, SC 29425 USA.
   [Ma, Jian-xing] Univ Oklahoma, Hlth Sci Ctr, Dept Physiol, Oklahoma City, OK USA.
C3 Queens University Belfast; University of Sydney; University of Oklahoma
   System; University of Oklahoma Health Sciences Center; University of
   Oklahoma System; University of Oklahoma Health Sciences Center; US
   Department of Veterans Affairs; Veterans Health Administration (VHA);
   Edward Hines Jr. VA Hospital; State University of New York (SUNY)
   System; University at Buffalo, SUNY; Medical University of South
   Carolina; University of Oklahoma System; University of Oklahoma Health
   Sciences Center
RP Lyons, TJ (corresponding author), Queens Univ Belfast, Ctr Med Expt, ICS A, Grosvenor Rd, Belfast BT12 6BA, Antrim, North Ireland.
EM t.lyons@qub.ac.uk
RI Jenkins, Alicia/N-2482-2015
OI Jenkins, Alicia/0000-0003-0583-3717; Lyons, Timothy/0000-0003-2106-1622;
   Azar, Madona/0000-0001-8339-9018
FU National Heart Lung and Blood Institute Research [P01 HL55782]; National
   Institute for Diabetes, Digestive, and Kidney Diseases [R01 DK080043,
   R21 HL80921]; American Diabetes Association Research [1-09-CR-38,
   7-12-CT-46]; Medical University of South Carolina General Clinical
   Research Center [M01-RR-1070]; University of Oklahoma General Clinical
   Research Center [M01-RR-14467]
FX Supported by National Heart Lung and Blood Institute Research Grant P01
   HL55782; National Institute for Diabetes, Digestive, and Kidney Diseases
   Grants R01 DK080043 and R21 HL80921; American Diabetes Association
   Research Grants (1-09-CR-38 and 7-12-CT-46); the Medical University of
   South Carolina General Clinical Research Center (Grant M01-RR-1070); the
   University of Oklahoma General Clinical Research Center (Grant
   M01-RR-14467), and GlaxoSmithKline, which provided logistic support. The
   VA Diabetes Trial was supported by the Veterans Affairs Cooperative
   Studies Program, Department of Veterans Affairs Office of Research and
   Development; the American Diabetes Association; and the National Eye
   Institute. Pharmaceutical and other supplies and financial assistance
   for VADT were provided by GlaxoSmithKline, Novo Nordisk, Roche
   Diagnostics, Sanofi-Aventis, Amylin, and Kos Pharmaceuticals.
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NR 51
TC 20
Z9 22
U1 0
U2 3
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1056-8727
EI 1873-460X
J9 J DIABETES COMPLICAT
JI J. Diabetes Complications
PD MAY-JUN
PY 2014
VL 28
IS 3
BP 353
EP 359
DI 10.1016/j.jdiacomp.2014.01.008
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA AG9DB
UT WOS:000335717800019
PM 24560422
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Kien, CL
   Bunn, JY
   Poynter, ME
   Stevens, R
   Bain, J
   Ikayeva, O
   Fukagawa, NK
   Champagne, CM
   Crain, KI
   Koves, TR
   Muoio, DM
AF Kien, C. Lawrence
   Bunn, Janice Y.
   Poynter, Matthew E.
   Stevens, Robert
   Bain, James
   Ikayeva, Olga
   Fukagawa, Naomi K.
   Champagne, Catherine M.
   Crain, Karen I.
   Koves, Timothy R.
   Muoio, Deborah M.
TI A Lipidomics Analysis of the Relationship Between Dietary Fatty Acid
   Composition and Insulin Sensitivity in Young Adults
SO DIABETES
LA English
DT Article
ID SKELETAL-MUSCLE; METABOLIC SYNDROME; RESISTANCE; GLUCOSE; IRON;
   PALMITATE; RISK; ACCUMULATION; ACTIVATION; OXIDATION
AB Relative to diets enriched in palmitic acid (PA), diets rich in oleic acid (OA) are associated with reduced risk of type 2 diabetes. To gain insight into mechanisms underlying these observations, we applied comprehensive lipidomic profiling to specimens collected from healthy adults enrolled in a randomized, crossover trial comparing a high-PA diet to a low-PA/high-OA (HOA) diet. Effects on insulin sensitivity (S-I) and disposition index (DI) were assessed by intravenous glucose tolerance testing. In women, but not men, S-I and DI were higher during HOA. The effect of HOA on S-I correlated positively with physical fitness upon enrollment. Principal components analysis of either fasted or fed-state metabolites identified one factor affected by diet and heavily weighted by the PA/OA ratio of serum and muscle lipids. In women, this factor correlated inversely with S-I in the fasted and fed states. Medium-chain acylcarnitines emerged as strong negative correlates of S-I, and the HOA diet was accompanied by lower serum and muscle ceramide concentrations and reductions in molecular biomarkers of inflammatory and oxidative stress. This study provides evidence that the dietary PA/OA ratio impacts diabetes risk in women. Diabetes 62:1054-1063, 2013
C1 [Kien, C. Lawrence] Univ Vermont, Dept Pediat, Burlington, VT 05401 USA.
   [Kien, C. Lawrence; Poynter, Matthew E.; Fukagawa, Naomi K.; Crain, Karen I.] Univ Vermont, Dept Med, Burlington, VT USA.
   [Bunn, Janice Y.] Univ Vermont, Dept Med Biostat, Burlington, VT USA.
   [Stevens, Robert; Bain, James; Ikayeva, Olga; Koves, Timothy R.; Muoio, Deborah M.] Duke Univ, Stedman Nutr & Metab Ctr, Durham, NC USA.
   [Stevens, Robert; Bain, James; Ikayeva, Olga; Koves, Timothy R.; Muoio, Deborah M.] Duke Univ, Dept Med, Durham, NC USA.
   [Stevens, Robert; Bain, James; Ikayeva, Olga; Koves, Timothy R.; Muoio, Deborah M.] Duke Univ, Dept Pharmacol & Canc Biol, Durham, NC USA.
   [Champagne, Catherine M.] Pennington Biomed Res Ctr, Baton Rouge, LA USA.
C3 University of Vermont; University of Vermont; University of Vermont;
   Duke University; Duke University; Duke University; Louisiana State
   University System; Louisiana State University; Pennington Biomedical
   Research Center
RP Kien, CL (corresponding author), Univ Vermont, Dept Pediat, Burlington, VT 05401 USA.
EM cl.kien@uvm.edu
RI Champagne, Catherine/N-1956-2017; Koves, Tim/I-4806-2012; Stevens,
   Robert/AFY-2273-2022; Muoio, Debbie/E-1147-2012
OI Poynter, Matthew/0000-0002-7578-4570; Muoio,
   Deborah/0000-0003-3760-9277; Bain, James R./0000-0002-8917-9187;
   Fukagawa, Naomi/0000-0001-5954-9039; Koves, Timothy/0000-0001-8763-5866
FU National Institutes of Health [R01-DK-073284, R01-DK-082803]; National
   Center for Research Resources, National Institutes of Health, U.S.
   Public Health Service [RR-00109]
FX This study was supported by National Institutes of Health Grants
   R01-DK-073284 and R01-DK-082803, and these studies were conducted at The
   University of Vermont GCRC, funded by grant RR-00109 from the National
   Center for Research Resources, National Institutes of Health, U.S.
   Public Health Service.
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NR 50
TC 107
Z9 114
U1 0
U2 41
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0012-1797
EI 1939-327X
J9 DIABETES
JI Diabetes
PD APR
PY 2013
VL 62
IS 4
BP 1054
EP 1063
DI 10.2337/db12-0363
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 111MS
UT WOS:000316526000015
PM 23238293
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Wu, ZL
   Satterfield, MC
   Bazer, FW
   Wu, GY
AF Wu, Zhenlong
   Satterfield, Michael C.
   Bazer, Fuller W.
   Wu, Guoyao
TI Regulation of brown adipose tissue development and white fat reduction
   by L-arginine
SO CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE
LA English
DT Review
DE brown adipose tissue; L-arginine; metabolism; obesity
ID CONJUGATED LINOLEIC-ACID; NITRIC-OXIDE; DIETARY SUPPLEMENTATION;
   TRANSCRIPTIONAL CONTROL; METABOLIC SYNDROME; GROWTH-FACTOR; AMINO-ACIDS;
   MECHANISMS; EXPRESSION; NUTRITION
AB Purpose of review
   Brown adipose tissue (BAT), which is present in humans, plays an important role in oxidation of fatty acids and glucose. The purpose of this review is to highlight an important role for L-arginine in regulating BAT growth and development, thereby reducing obesity in mammals.
   Recent findings
   Dietary supplementation with L-arginine reduces white adipose tissue in genetically or diet-induced obese rats, obese pregnant sheep, and obese humans with type II diabetes. L-arginine treatment enhances BAT growth in both fetuses and postnatal animals. At molecular and cellular levels, L-arginine stimulates expression of peroxisome proliferator-activated receptor-gamma coactivator 1 (the master regulator of mitochondrial biogenesis), nitric oxide synthase, heme oxygenase, and adenosine monophosphate-activated protein kinase. At the whole body level, L-arginine increases blood flow to insulin-sensitive tissues, adipose tissue lipolysis, and the catabolism of glucose and fatty acids, but inhibits fatty acid synthesis and ameliorates oxidative stress, thereby improving metabolic profile.
   Summary
   L-arginine increases mammalian BAT growth and development via mechanisms involving gene expression, nitric oxide signaling, and protein synthesis. This enhances the oxidation of energy substrates and, thus, reduces white fat accretion in the body. L-arginine holds great promise in preventing and treating obesity in humans.
C1 [Satterfield, Michael C.; Bazer, Fuller W.; Wu, Guoyao] Texas A&M Univ, Fac Nutr, College Stn, TX 77843 USA.
   [Satterfield, Michael C.; Bazer, Fuller W.; Wu, Guoyao] Texas A&M Univ, Dept Anim Sci, College Stn, TX 77843 USA.
   [Wu, Zhenlong; Wu, Guoyao] China Agr Univ, Coll Anim Sci & Technol, State Key Lab Anim Nutr, Beijing 100094, Peoples R China.
C3 Texas A&M University System; Texas A&M University College Station; Texas
   A&M University System; Texas A&M University College Station; China
   Agricultural University
RP Wu, GY (corresponding author), Texas A&M Univ, Fac Nutr, College Stn, TX 77843 USA.
EM g-wu@tamu.edu
RI Bazer, Fuller/AAF-4317-2021
FU National Natural Science Foundation of China [31172217]; Thousand-People
   Talent program at China Agricultural University, Chinese Universities
   Scientific Funds [2012RC024]; USDA National Research Initiative
   Competitive Grants from the Animal Reproduction Program
   [2008-35203-19120]; Animal Growth & Nutrient Utilization Program
   [2008-35206-18764, 2009-35206-05211]; American Heart Association
   [10GRNT4480020]
FX The work was supported, in part, by National Natural Science Foundation
   of China grants (No. 31172217), the Thousand-People Talent program at
   China Agricultural University, Chinese Universities Scientific Funds
   (No. 2012RC024), the USDA National Research Initiative Competitive
   Grants from the Animal Reproduction Program (No. 2008-35203-19120) and
   Animal Growth & Nutrient Utilization Program (No. 2008-35206-18764 and
   2009-35206-05211), and American Heart Association (No. 10GRNT4480020).
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NR 62
TC 62
Z9 67
U1 1
U2 45
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1363-1950
EI 1473-6519
J9 CURR OPIN CLIN NUTR
JI Curr. Opin. Clin. Nutr. Metab. Care
PD NOV
PY 2012
VL 15
IS 6
BP 529
EP 538
DI 10.1097/MCO.0b013e3283595cff
PG 10
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 027OI
UT WOS:000310362000003
PM 23075933
DA 2025-06-11
ER

PT J
AU Bonsignore, MR
   McNicholas, WT
   Montserrat, JM
   Eckel, J
AF Bonsignore, M. R.
   McNicholas, W. T.
   Montserrat, J. M.
   Eckel, J.
TI Adipose tissue in obesity and obstructive sleep apnoea
SO EUROPEAN RESPIRATORY JOURNAL
LA English
DT Review
DE Adipocyte; dyslipidaemia; hypoxia; liver dysfunction; obesity
ID POSITIVE AIRWAY PRESSURE; FATTY LIVER-DISEASE; CHRONIC INTERMITTENT
   HYPOXIA; CARDIOVASCULAR RISK-FACTORS; SERUM AMINOTRANSFERASE LEVELS;
   LIFE-STYLE INTERVENTION; 3RD NATIONAL-HEALTH; BODY-MASS INDEX;
   DENSITY-LIPOPROTEIN CHOLESTEROL; ENDOPLASMIC-RETICULUM STRESS
AB A European Respiratory Society research seminar on "Metabolic alterations in obstructive sleep apnoea (OSA)'' was jointly organised in October 2009 together with two EU COST actions (Cardiovascular risk in the obstructive sleep apnoea syndrome, action B26, and Adipose tissue and the metabolic syndrome, action BM0602) in order to discuss the interactions between obesity and OSA.
   Such interactions can be particularly significant in the pathogenesis of metabolic abnormalities and in increased cardiovascular risk in OSA patients. However, studying the respective role of OSA and obesity is difficult in patients, making it necessary to refer to animal models or in vitro systems. Since most OSA patients are obese, their management requires a multidisciplinary approach.
   This review summarises some aspects of the pathophysiology and treatment of obesity, and the possible effects of sleep loss on metabolism. OSA-associated metabolic dysfunction (insulin resistance, liver dysfunction and atherogenic dyslipidaemia) is discussed from the perspective of both obesity and OSA in adults and children.
   Finally, the effects of treatment for obesity or OSA, or both, on cardio-metabolic variables are summarised. Further interdisciplinary research is needed in order to develop new comprehensive treatment approaches aimed at reducing sleep disordered breathing, obesity and cardiovascular risk.
C1 [Bonsignore, M. R.] Univ Palermo, Biomed Dept Internal & Specialist Med DIBIMIS, V Cervello Hosp, Sect Pneumol, I-90146 Palermo, Italy.
   [Bonsignore, M. R.] Natl Res Council CNR, Inst Biomed & Mol Immunol IBIM, Palermo, Italy.
   [McNicholas, W. T.] St Vincents Univ Hosp, Pulm & Sleep Disorders Unit, Dublin 4, Ireland.
   [Montserrat, J. M.] Hosp Clin IDIBAPS CIBERES, Sleep Lab, Barcelona, Spain.
   [Eckel, J.] German Diabet Ctr, Dusseldorf, Germany.
C3 University of Palermo; Consiglio Nazionale delle Ricerche (CNR);
   Istituto di Biomedicina e di Immunologia Molecolare "Alberto Monroy"
   (IBIM-CNR); University College Dublin; Saint Vincent's University
   Hospital; University of Barcelona; Hospital Clinic de Barcelona;
   IDIBAPS; CIBER - Centro de Investigacion Biomedica en Red; CIBERES;
   Leibniz Association; Deutsches Diabetes-Zentrum (DDZ)
RP Bonsignore, MR (corresponding author), Univ Palermo, Biomed Dept Internal & Specialist Med DIBIMIS, V Cervello Hosp, Sect Pneumol, Via Trabucco 180, I-90146 Palermo, Italy.
EM marisa@ibim.cnr.it
RI Mora, Josep/A-9355-2013; Bonsignore, Maria R/U-6440-2017
OI Eckel, Juergen/0000-0003-3645-5288; Bonsignore, Maria
   R/0000-0002-4875-7796; MONTSERRAT, Josep Maria/0000-0003-3098-4605
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NR 396
TC 89
Z9 95
U1 0
U2 17
PU EUROPEAN RESPIRATORY SOC JOURNALS LTD
PI SHEFFIELD
PA 442 GLOSSOP RD, SHEFFIELD S10 2PX, ENGLAND
SN 0903-1936
EI 1399-3003
J9 EUR RESPIR J
JI Eur. Resp. J.
PD MAR
PY 2012
VL 39
IS 3
BP 746
EP 767
DI 10.1183/09031936.00047010
PG 22
WC Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Respiratory System
GA 900JS
UT WOS:000300883800032
PM 21920888
OA Bronze
DA 2025-06-11
ER

PT J
AU Anand, K
   Walia, GK
   Mandal, S
   Menon, JS
   Gupta, R
   Tandon, N
   Narayan, KMV
   Ali, MK
   Mohan, V
   Schwartz, JD
   Prabhakaran, D
AF Anand, Kritika
   Walia, Gagandeep Kaur
   Mandal, Siddhartha
   Menon, Jyothi S.
   Gupta, Ruby
   Tandon, Nikhil
   Narayan, K. M. Venkat
   Ali, Mohammed K.
   Mohan, Viswanathan
   Schwartz, Joel D.
   Prabhakaran, Dorairaj
TI Longitudinal associations between ambient PM2.5 exposure and
   lipid levels in two Indian cities
SO ENVIRONMENTAL EPIDEMIOLOGY
LA English
DT Article
DE India; LMIC; Particulate matter; Lipids; Ambient air pollution;
   Cardiometabolic diseases
ID LONG-TERM EXPOSURE; DENSITY-LIPOPROTEIN CHOLESTEROL; AIR-POLLUTION
   EXPOSURE; BLOOD-LIPIDS; PARTICULATE MATTER; GLUCOSE; ADULTS;
   DYSLIPIDEMIAS; EPIDEMIOLOGY; CAPACITY
AB Background: Exposure to ambient PM2.5 is known to affect lipid metabolism through systemic inflammation and oxidative stress. Evidence from developing countries, such as India with high levels of ambient PM2.5 and distinct lipid profiles, is sparse. Methods: Longitudinal nonlinear mixed-effects analysis was conducted on >10,000 participants of Centre for cArdiometabolic Risk Reduction in South Asia (CARRS) cohort in Chennai and Delhi, India. We examined associations between 1-month and 1-year average ambient PM2.5 exposure derived from the spatiotemporal model and lipid levels (total cholesterol [TC], triglycerides [TRIG], high-density lipoprotein cholesterol [HDL-C], and low-density lipoprotein cholesterol [LDL-C]) measured longitudinally, adjusting for residential and neighborhood-level confounders. Results: The mean annual exposure in Chennai and Delhi was 40 and 102 mu g/m(3) respectively. Elevated ambient PM2.5 levels were associated with an increase in LDL-C and TC at levels up to 100 mu g/m(3) in both cities and beyond 125 mu g/m(3) in Delhi. TRIG levels in Chennai increased until 40 mu g/m(3) for both short- and long-term exposures, then stabilized or declined, while in Delhi, there was a consistent rise with increasing annual exposures. HDL-C showed an increase in both cities against monthly average exposure. HDL-C decreased slightly in Chennai with an increase in long-term exposure, whereas it decreased beyond 130 mu g/m(3) in Delhi. Conclusion: These findings demonstrate diverse associations between a wide range of ambient PM2.5 and lipid levels in an understudied South Asian population. Further research is needed to establish causality and develop targeted interventions to mitigate the impact of air pollution on lipid metabolism and cardiovascular health.
C1 [Anand, Kritika; Mandal, Siddhartha; Menon, Jyothi S.; Gupta, Ruby; Prabhakaran, Dorairaj] Ctr Chron Dis Control, New Delhi, India.
   [Walia, Gagandeep Kaur; Menon, Jyothi S.; Gupta, Ruby; Prabhakaran, Dorairaj] Publ Hlth Fdn India, Gurugram, India.
   [Tandon, Nikhil] All India Inst Med Sci, New Delhi, India.
   [Narayan, K. M. Venkat; Ali, Mohammed K.] Emory Global Diabet Res Ctr, Woodruff Hlth Sci Ctr, Atlanta, GA USA.
   [Narayan, K. M. Venkat; Ali, Mohammed K.] Emory Univ, Rollins Sch Publ Hlth, Atlanta, GA USA.
   [Mohan, Viswanathan] Madras Diabet Res Fdn MDRF, Chennai, India.
   [Schwartz, Joel D.] Harvard Univ, Harvard TH Chan Sch Publ Hlth, Boston, MA USA.
   [Anand, Kritika] Ctr Chron Dis Control, C-1-52,2ND Floor, Delhi 110016, India.
C3 Public Health Foundation of India; All India Institute of Medical
   Sciences (AIIMS) New Delhi; Emory University; Rollins School Public
   Health; Madras Diabetes Research Foundation; Harvard University; Harvard
   T.H. Chan School of Public Health
RP Anand, K (corresponding author), Ctr Chron Dis Control, C-1-52,2ND Floor, Delhi 110016, India.
EM kritika.anand@ccdcindia.org
RI Menon, Jyothi S/AFD-6123-2022; Viswanathan, Mohan/C-2321-2009; Narayan,
   K.M./J-9819-2012
OI Anand, Kritika/0000-0002-2407-0156; Menon, Jyothi S/0000-0001-6398-2513
FU Fogarty International Center of the National Institutes of Health,
   National Institute of Environmental Health Sciences; National Cancer
   Institute, under the Global Environmental and Occupational Health Hub
   research grant [U01 TW010097]; National Heart, Lung, and Blood
   Institute, National Institutes of Health, Department of Health and Human
   Services [HHSN268200900026C, P01HL154996]; United-Health Group,
   Minneapolis, Minnesota
FX Supported by the Fogarty International Center of the National Institutes
   of Health, National Institute of Environmental Health Sciences, and
   National Cancer Institute, under the Global Environmental and
   Occupational Health Hub research grant (award number U01 TW010097). The
   Center for cArdiometabolic Risk Reduction in South Asia (CARRS) cohort
   has been funded, in part, with federal funds from the United States, the
   National Heart, Lung, and Blood Institute, National Institutes of
   Health, Department of Health and Human Services, under contract no.
   HHSN268200900026C and award number P01HL154996, and the United-Health
   Group, Minneapolis, Minnesota. Financial support for open-access
   publishing will be provided.
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NR 47
TC 4
Z9 4
U1 1
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
EI 2474-7882
J9 ENVIRON EPIDEMIOL
JI Environ. Epidemiol.
PD APR
PY 2024
VL 8
IS 2
AR e295
DI 10.1097/EE9.0000000000000295
PG 10
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Emerging Sources Citation Index (ESCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA MX3Z0
UT WOS:001196908700001
PM 38617424
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Yao, Y
   Chen, DY
   Yin, JW
   Zhou, L
   Cheng, JQ
   Lu, SY
   Li, HH
   Wen, Y
   Wu, Y
AF Yao, Yao
   Chen, Ding-Yan
   Yin, Jiang-Wei
   Zhou, Li
   Cheng, Jin-Quan
   Lu, Shao-You
   Li, Hong-Hua
   Wen, Ying
   Wu, Yu
TI Phthalate exposure linked to high blood pressure in Chinese children
SO ENVIRONMENT INTERNATIONAL
LA English
DT Article
DE Phthalate metabolites; Children; Blood pressure; Hypertension; Exposure
ID URINARY HEAVY-METAL; PERSONAL CARE PRODUCTS; DI(2-ETHYLHEXYL)PHTHALATE
   DEHP; US NHANES; CARDIOMETABOLIC RISK; OXIDATIVE STRESS; PULSE PRESSURE;
   METABOLITES; HYPERTENSION; ASSOCIATION
AB Background: Exposure to phthalate esters may be linked to the risk of high blood pressure (HBP), but limited evidence is available in Chinese children.
   Objective: To investigate the associations between nine phthalate metabolites (mPAEs) and systolic/diastolic BP, pulse pressure (PP), mean arterial pressure (MAP), and the risk of HBP.
   Methods: In this cross-sectional study, a total of 1044 primary school children (6-8 years old) were enrolled from Shenzhen, China, between 2016 and 2017. Nine mPAEs were analyzed from urine using ultra-performance liquid chromatography and tandem mass spectrometry. A multivariable linear regression model was used to explore the associations between phthalate exposure and systolic/diastolic BP, PP, and MAP. A binary logistic regression model was used to examine the associations between phthalate exposure and the risk of HBP.
   Results: Monomethyl phthalate (MMP) concentrations were significantly higher in HBP children than normal BP children. MMP, monoisobutyl phthalate (MiBP), monobutyl phthalate (MnBP), mono(5-carboxy-2-ethylpentyl) phthalate, mono-[(2-carboxy methyl)hexyl] phthalate (MCMHP), the sum of four short-chain mPAEs (Sigma LMW), and the sum of all nine mPAEs (Sigma(9)mPAEs) were significantly positively associated with increases in systolic BP z-score, while only MMP was significantly positively associated with diastolic BP z-score. MMP, MiBP, MnBP, MCMHP, Sigma LMW, and Sigma(9)mPAEs were significantly associated with increases in PP, while MMP and MnBP were significantly associated with increases in MAP. MMP was significantly associated with the risk of HBP, with an odds ratio of 1.87 (95% CI: 1.23, 2.85).
   Conclusions: The present study suggests that dimethyl phthalate exposure increases the risk of HBP. And some types of phthalates are associated with elevations in systolic/diastolic BP z scores, PP, and MAP in Chinese children.
C1 [Yao, Yao; Chen, Ding-Yan; Zhou, Li; Cheng, Jin-Quan; Wen, Ying; Wu, Yu] Shenzhen Ctr Dis Control & Prevent, Shenzhen 518055, Peoples R China.
   [Yao, Yao] Huazhong Univ Sci & Technol, Sch Publ Hlth, Key Lab Environm & Hlth, Dept Occupat & Environm Hlth, Wuhan 430030, Peoples R China.
   [Lu, Shao-You] Sun Yat Sen Univ, Sch Publ Hlth Shenzhen, Guangzhou 510275, Peoples R China.
   [Yin, Jiang-Wei; Li, Hong-Hua] Baoan Dist Ctr Dis Control & Prevent, Shenzhen 518101, Peoples R China.
C3 Shenzhen Center for Disease Control & Prevention (SZCDC); Huazhong
   University of Science & Technology; Sun Yat Sen University
RP Zhou, L; Cheng, JQ (corresponding author), Shenzhen Ctr Dis Control & Prevent, Shenzhen 518055, Peoples R China.
EM alli99@126.com; cjinquan@szcdc.net
RI Liang, Chen/HNP-5916-2023; Lu, Shaoyou/JSK-4241-2023; YAO,
   YAO/KQU-8003-2024
OI Yao, Yao/0000-0001-9604-5358
FU National Natural Science Foundation of China [81673201]; Shenzhen
   Municipal Government Research Projects [JCYJ20180307095536403,
   JCYJ20160428143108182]; China Postdoctoral Science Foundation
   [2018M633154]; Sanming Project of Medicine in Shenzhen [SZSM201511007]
FX We thank all the participants for their generous collaborations and
   school physicians for their tremendous help. We sincerely thank
   Qing-Shan Luo, Yuan-Yuan Huang, Xuehua Li, Ying-Ying Li, Fan-Shun Meng,
   and Fan Lei for their support with project organization and urine sample
   collection. The present research was financially supported by the
   National Natural Science Foundation of China (No. 81673201), the
   Shenzhen Municipal Government Research Projects (Nos.
   JCYJ20180307095536403 and JCYJ20160428143108182), the China Postdoctoral
   Science Foundation (No. 2018M633154), and the Sanming Project of
   Medicine in Shenzhen (No. SZSM201511007).
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NR 67
TC 32
Z9 33
U1 4
U2 59
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0160-4120
EI 1873-6750
J9 ENVIRON INT
JI Environ. Int.
PD OCT
PY 2020
VL 143
AR 105958
DI 10.1016/j.envint.2020.105958
PG 8
WC Environmental Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology
GA PK2YU
UT WOS:000602318000018
PM 32688158
OA gold
DA 2025-06-11
ER

PT J
AU Cenko, E
   Bergami, M
   Varotti, E
   Bugiardini, R
AF Cenko, Edina
   Bergami, Maria
   Varotti, Elisa
   Bugiardini, Raffaele
TI Vasospastic Angina and its Relationship with the Coronary
   Microcirculation
SO CURRENT PHARMACEUTICAL DESIGN
LA English
DT Review
DE Coronary vasospasm; angina; coronary microcirculation; endothelial
   dysfunction; myocardial infarction; epicardial vasospasm
ID ISCHEMIC-HEART-DISEASE; COLD PRESSOR TEST; ARTERY-DISEASE; VARIANT
   ANGINA; MYOCARDIAL-ISCHEMIA; ENDOTHELIAL DYSFUNCTION; EUROPEAN-SOCIETY;
   VASOTONIC ANGINA; WORKING GROUP; SYNDROME-X
AB Vasospastic angina is an important cause of chest pain due to coronary artery vasospasm that is related to poor quality of life and can lead to myocardial infarction, arrhythmias and death. Since its first description as "Prinzmetal or variant angina" which was believed to be a focal spam that occurred in non-obstructed epicardial coronary arteries, physician and researchers were gradually confronted with the clinical reality and came to the conclusion that the coronary artery vasospasm was considerably more polymorphic than initially described. Although mechanism leading to vasospastic angina is not completely understood, nowadays the medical community acknowledges that it exhibits a large variability in clinical practice ranging from focal to diffuse epicardial vasospasm. Main proposed mechanisms are impairment of parasympathetic activity, coronary vascular and microvascular dysfunction due to blunted response to nitric oxide endothelium-dependent coronary vasodilatation, increased release of vasoconstricts, and oxidative stress.
C1 [Cenko, Edina; Bergami, Maria; Varotti, Elisa; Bugiardini, Raffaele] Univ Bologna, Dept Expt Diagnost & Specialty Med, Via Massarenti 9, I-40138 Bologna, Italy.
C3 University of Bologna
RP Cenko, E (corresponding author), Univ Bologna, Dept Expt Diagnost & Specialty Med, Via Massarenti 9, I-40138 Bologna, Italy.
EM edina.cenko2@unibo.it
RI Cenko, Edina/L-6438-2015; Bugiardini, Raffaele/L-6446-2015; Bergami,
   Maria/GVS-8700-2022
OI Bergami, Maria/0000-0002-1389-0597
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NR 72
TC 6
Z9 6
U1 0
U2 7
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1381-6128
EI 1873-4286
J9 CURR PHARM DESIGN
JI Curr. Pharm. Design
PY 2018
VL 24
IS 25
BP 2906
EP 2910
DI 10.2174/1381612824666180625150833
PG 5
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA HA2MQ
UT WOS:000450073300004
PM 29938613
DA 2025-06-11
ER

PT J
AU Rentería-Mexía, A
   Vega-López, S
   Olson, ML
   Swan, PD
   Lee, CD
   Williams, AN
   Shaibi, GQ
AF Renteria-Mexia, Ana
   Vega-Lopez, Sonia
   Olson, Micah L.
   Swan, Pamela D.
   Lee, Chong D.
   Williams, Allison N.
   Shaibi, Gabriel Q.
TI Effects of a lifestyle intervention on markers of cardiometabolic risk
   and oxidized lipoproteins among obese adolescents with prediabetes
SO PUBLIC HEALTH NUTRITION
LA English
DT Article
DE Prediabetes; Obese Latino adolescents; Oxidized lipoproteins; Oxidized
   LDL; Oxidized HDL
ID HIGH-DENSITY-LIPOPROTEIN; DIABETES PREVENTION PROGRAM; OXIDATIVE STRESS
   MARKERS; INSULIN-RESISTANCE; CARDIOVASCULAR RISK; LATINO YOUTH;
   WEIGHT-LOSS; CHILDREN; PLASMA; HDL
AB Objective: Obesity and hyperglycaemia contribute to the atherosclerotic process in part through oxidative modifications to lipoprotein particles. The present study aimed to evaluate the effects of a lifestyle intervention on markers of oxidized lipoproteins in obese Latino adolescents with prediabetes.
   Design: Pre-post design.
   Setting: Participants were enrolled into a 12-week lifestyle intervention. Measurements pre- and post-intervention included anthropometrics and body composition, lipid panel, oxidized LDL (oxLDL), oxidized HDL (oxHDL), intake of fresh fruits and vegetables, and cardiorespiratory fitness.
   Participants: Thirty-five obese Latino adolescents (seventeen females, eighteen males; mean age 15.5 (SD 1.0) years; mean BMI percentile 98.5 (SD 1.2)) with prediabetes.
   Results: Intervention participation resulted in significant reductions in weight (-1.2%, P=0.042), BMI and BMI percentile (-2.0 and -0.4%, respectively, P< 0.001), body fat (-7.0%, P= 0.025), TAG (-11.8%, P= 0.032), total cholesterol (-5.0 %, P= 0.002), VLDL-cholesterol (-12.5 %, P= 0.029), and non-HDL-cholesterol (-6.7%, P=0.007). Additionally, fitness (6.4%, P< 0.001) and intake of fruits and vegetables (42.4 %, P= 0.025) increased significantly. 0-xLIM. decreased significantly after the intervention (51.0 (SD 14.0) v. 48.7 (SD 12.8) U/l, P=0.022), while oxHDL trended towards a significant increase (395.2 (SD 94.6) v. 416.1 (SD 98.4) ng/ml, P= 0.056).
   Conclusions: These data support the utility of lifestyle intervention to improve the atherogenic phenotype of Latino adolescents who are at high risk for developing premature CVD and type 2 diabetes.
C1 [Renteria-Mexia, Ana] Inst Tecnol Sonora, Dept Biotecnol & Ciencias Alimentarias, Obregon, Sonora, Mexico.
   [Renteria-Mexia, Ana; Vega-Lopez, Sonia; Swan, Pamela D.; Lee, Chong D.; Shaibi, Gabriel Q.] Arizona State Univ, Sch Nutr & Hlth Promot, Phoenix, AZ 85004 USA.
   [Vega-Lopez, Sonia; Shaibi, Gabriel Q.] Arizona State Univ, Southwest Interdisciplinary Res Ctr, Phoenix, AZ 85004 USA.
   [Olson, Micah L.; Shaibi, Gabriel Q.] Phoenix Childrens Hosp, Div Endocrinol & Diabet, Phoenix, AZ 85016 USA.
   [Olson, Micah L.; Williams, Allison N.; Shaibi, Gabriel Q.] Arizona State Univ, Coll Nursing & Hlth Innovat, Ctr Hlth Promot & Dis Prevent, 500 N 3rd St, Phoenix, AZ 85004 USA.
C3 Arizona State University; Arizona State University-Downtown Phoenix;
   Arizona State University; Arizona State University-Downtown Phoenix;
   Phoenix Children's Hospital; Arizona State University; Arizona State
   University-Downtown Phoenix
RP Shaibi, GQ (corresponding author), Arizona State Univ, Sch Nutr & Hlth Promot, Phoenix, AZ 85004 USA.; Shaibi, GQ (corresponding author), Arizona State Univ, Southwest Interdisciplinary Res Ctr, Phoenix, AZ 85004 USA.; Shaibi, GQ (corresponding author), Phoenix Childrens Hosp, Div Endocrinol & Diabet, Phoenix, AZ 85016 USA.; Shaibi, GQ (corresponding author), Arizona State Univ, Coll Nursing & Hlth Innovat, Ctr Hlth Promot & Dis Prevent, 500 N 3rd St, Phoenix, AZ 85004 USA.
EM gabliel.shaibi@asu.edu
RI Renteria-Mexia, Ana/AHA-3451-2022
OI Shaibi, Gabriel/0000-0002-6890-2903; Renteria-Mexia,
   Ana/0000-0001-9760-1213
FU ASU Southwest Interdisciplinary Research Center, an Exploratory Center
   of Excellence for Health Disparities Research and Training through
   National Institutes of Health, National Institute on Minority Health and
   Health Disparities [P20MD002316]; ASU Office of Knowledge Enterprise
   Development, Graduate and Professional Student Association; Graduate
   College; Programa para el Desarrollo Profesional Docente en Educacion
   Superior (PRODEP), Mexico
FX This work was supported by the ASU Southwest Interdisciplinary Research
   Center, an Exploratory Center of Excellence for Health Disparities
   Research and Training, through a grant from the National Institutes of
   Health, National Institute on Minority Health and Health Disparities
   (grant number P20MD002316); and by the ASU Office of Knowledge
   Enterprise Development, Graduate and Professional Student Association,
   and the Graduate College. A.R.-M. was supported by the Programa para el
   Desarrollo Profesional Docente en Educacion Superior (PRODEP), Mexico,
   during her doctoral studies. The funders had no role in the design,
   analysis or writing of this article.
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NR 53
TC 2
Z9 2
U1 0
U2 3
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 1368-9800
EI 1475-2727
J9 PUBLIC HEALTH NUTR
JI Public Health Nutr.
PD MAR
PY 2019
VL 22
IS 4
BP 706
EP 713
DI 10.1017/S1368980018003476
PG 8
WC Public, Environmental & Occupational Health; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health; Nutrition & Dietetics
GA HQ8LZ
UT WOS:000462677500013
PM 30588900
OA Bronze, Green Published, Green Accepted
DA 2025-06-11
ER

PT J
AU Holloway, K
   Roche, D
   Angell, P
AF Holloway, Kathryn
   Roche, Denise
   Angell, Peter
TI Evaluating the progressive cardiovascular health benefits of short-term
   high-intensity interval training
SO EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
LA English
DT Article
DE High-intensity; Exercise training; Cardiac function; Vascular structure;
   Cardiovascular risk
ID PHYSICAL-ACTIVITY; BLOOD-PRESSURE; CARDIOMETABOLIC DISEASE; INTERMITTENT
   EXERCISE; MAGNETIC-RESONANCE; AUGMENTATION INDEX; PULSE PRESSURE;
   HEART-FAILURE; SHEAR-STRESS; NITRIC-OXIDE
AB High-intensity training is recognised as a time-efficient way of improving aerobic fitness. However, there is a lack of consensus regarding the temporal nature of adaptation response and which peripheral and cardiac changes occur using the same exercise stimulus and protocol. Therefore, this study aimed to evaluate the progression of vascular and cardiac changes over a 6-week training period.
   Twelve healthy males (age 21 +/- 2 years; 42.5 +/- 8.3 ml min(-1) kg(-1)) participated in a high-intensity training programme consisting of 1-min sprints, interspersed with 2 min active recovery, 3 days/week for 6 weeks on a cycle ergometer. Cardiac, vascular, blood lipids and VO2max measurements were taken at 0, 3 and 6 weeks and compared against a participant-matched control group (age 21 +/- 2 years; 37.7 +/- 8.3 ml min(-1) kg(-1)).
   There was a significant improvement in VO2max (42.5 +/- 8.3-47.4 +/- 8.5 ml min(-1) kg(-1); p = 0.009) in the training group and a significant decrease in systolic blood pressure (8%) from 0 to 6 weeks (p = 0.025). There was a small yet significant decrease in ejection fraction and increased end-systolic volume in both groups over time (p = 0.01) with no significant interaction effect (p > 0.05). A between-group difference in peak velocity of early diastolic mitral annular motion was also observed (p = 0.01). No improvements were seen in blood lipid profiles, central arterial stiffness and cardiometabolic risk score.
   Six weeks of high-intensity training increases aerobic fitness and is enough to stimulate initial reductions in peripheral pressure, but not sufficient to elicit structural and functional cardiac changes, reduce arterial stiffness or lower CV risk.
C1 [Holloway, Kathryn; Roche, Denise; Angell, Peter] Liverpool Hope Univ, Sch Hlth Sci, Hope Pk,Taggart Ave, Liverpool L16 9JD, Merseyside, England.
C3 University of Liverpool; Liverpool Hope University
RP Holloway, K (corresponding author), Liverpool Hope Univ, Sch Hlth Sci, Hope Pk,Taggart Ave, Liverpool L16 9JD, Merseyside, England.
EM hollowk@hope.ac.uk
RI Roche, Denise/LGZ-8754-2024
OI Angell, Peter/0000-0003-3613-1806; Roche, Denise/0000-0003-0045-0645
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NR 55
TC 17
Z9 21
U1 0
U2 32
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1439-6319
EI 1439-6327
J9 EUR J APPL PHYSIOL
JI Eur. J. Appl. Physiol.
PD OCT
PY 2018
VL 118
IS 10
BP 2259
EP 2268
DI 10.1007/s00421-018-3952-6
PG 10
WC Physiology; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology; Sport Sciences
GA GU3DZ
UT WOS:000445157300021
PM 30078106
DA 2025-06-11
ER

PT J
AU da Silva, IT
   Mello, APD
   Sanches, LB
   Abdalla, DSP
   Damasceno, NRT
AF da Silva, Isis Tande
   de Queiroz Mello, Ana Paula
   Sanches, Leticia Bertoldi
   Parra Abdalla, Dulcineia Saes
   Teixeira Damasceno, Nagila Raquel
TI Is Plasma Alpha-Tocopherol Associated with Electronegative LDL in Obese
   Adolescents?
SO JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY
LA English
DT Article
DE plasma alpha-tocopherol; electronegative low-density lipoprotein;
   obesity; adolescents
ID LOW-DENSITY-LIPOPROTEIN; OXIDATIVE STRESS MARKERS; C-REACTIVE PROTEIN;
   VITAMIN-E; ATHEROSCLEROTIC LESIONS; INSULIN-RESISTANCE; RISK-FACTORS;
   CHILDREN; SUPPLEMENTATION; DISEASE
AB Obesity has increased in children and adolescents. What is reflected in the early occurrence of cardiometabolic alterations, like hypertension and type 2 diabetes, where the oxLDL formation is stimulated. Various studies have shown that plasma alpha-tocopherol (alpha-TP) can protect LDL against oxidation. Nevertheless, the action of plasma alpha-TP in cardiovascular diseases remains controversial. We conducted a cross-sectional study to evaluate plasma alpha-TP and its impact on the concentration of LDL(-). Adolescents (n=150) of both sexes were classified into three groups: healthy weight (HW; 50%), overweight (OV; 22%), and obese (OB; 28%). Lipid profile, LDL(-), anti-oxLDL and anti-LDL(-) antibodies, CRP (ELISA) and plasma alpha-TP (HPLC) were analyzed. Demographic, anthropometric, and food intake data were evaluated. Crude and energy-adjusted intake of vitamin E in the OB group were higher than in the HW group (p<0.001). Crude and energy-adjusted vitamin E intakes were not correlated with plasma alpha-TP (r=-0.07; p=0.412 and r=-0.064; p=0.467, respectively). Subjects in the OB group had higher TC and LDL-C and lower LDL-C than in the HW and OV groups. C-reactive protein and anti-oxLDL antibodies changed as a function of BMI. The impact of obesity was reinforced by high values for LDL(-) and low content of plasma alpha-TP in comparison with the HW (p<0.001) and OV groups (p=0.03). This negative profile was maintained for the ratio between alpha-TP and TC or LDL-C. Plasma alpha-TP, alpha-TP/TC and alpha-TP/LDL-C were negatively associated with LDL(-) and other cardiometabolic risk factors (BMI WC, AC and anti-oxLDL). Our results demonstrate that obesity in adolescents is associated with high levels of LDL(-) and low plasma alpha-TP content.
C1 [da Silva, Isis Tande; de Queiroz Mello, Ana Paula; Sanches, Leticia Bertoldi; Teixeira Damasceno, Nagila Raquel] Univ Sao Paulo, Sch Publ Hlth, Dept Nutr, Sao Paulo, Brazil.
   [Parra Abdalla, Dulcineia Saes] Univ Sao Paulo, Fac Pharmaceut Sci, Dept Clin Anal & Biochem, Sao Paulo, Brazil.
C3 Universidade de Sao Paulo; Universidade de Sao Paulo
RP da Silva, IT (corresponding author), Univ Sao Paulo, Sch Publ Hlth, Dept Nutr, Sao Paulo, Brazil.
EM tande.isis@gmail.com
RI da Silva, Isis/AHD-5580-2022; Damasceno, Nagila/D-9816-2012
OI Damasceno, Nagila/0000-0002-9332-7816
FU FAPESP [04/14517-6]
FX The authors would like to thank Jose Alfredo Gomes Areas (PhD) and
   Rosana Aparecida Manolio Soares (MSc) for their technical assistance
   with HPLC analysis. The authors acknowledge Dr Paulo Boschcov, former
   professor at UNIFESP, whose suggestions contributed to improve the
   quality of the final version of the manuscript. The present study was
   supported by FAPESP (grant to NRTD #04/14517-6).
CR [Anonymous], INT J ATHEROSCLER
   [Anonymous], REV BRAS ANAL CLIN
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NR 47
TC 4
Z9 4
U1 0
U2 6
PU CENTER ACADEMIC PUBL JAPAN
PI TOKYO
PA 2-4-16 YAYOI, BUNKYO-KU, TOKYO, 113-0032, JAPAN
SN 0301-4800
EI 1881-7742
J9 J NUTR SCI VITAMINOL
JI J. Nutr. Sci. Vitaminol.
PD APR
PY 2013
VL 59
IS 2
BP 100
EP 107
DI 10.3177/jnsv.59.100
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 152MO
UT WOS:000319536000004
PM 23727639
OA gold
DA 2025-06-11
ER

PT J
AU Lautt, WW
AF Lautt, W. Wayne
TI Hepatalin: the missing link in prediabetes, obesity, and type 2 diabetes
SO CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
LA English
DT Review
DE AMIS; hepatalin; HISS; prediabetes; obesity
ID INSULIN-SENSITIZING SUBSTANCE; GESTATIONAL WEIGHT-GAIN; PRENATAL ETHANOL
   EXPOSURE; HEART-RATE-VARIABILITY; SENSITIVITY TEST RIST; SYNDROME-X;
   HYPERGLYCEMIC RESPONSE; ANTIOXIDANT COCKTAIL; MATERNAL OBESITY;
   OXIDATIVE STRESS
AB Hepatalin is a hormone secreted by the liver in response to pulses of insulin after a mixed nutrient meal, but only if the liver receives two permissive synergistic feeding signals from the stomach. Hepatalin stimulates glucose uptake and storage as glycogen in skeletal muscle, heart, and kidney but not liver, intestines, or adipocytes. Insulin acts primarily on liver and fat. Reduced hepatalin action results in postprandial hyperglycemia, compensatory elevation of insulin secretion, and a re-sultant shift in partitioning of nutrient energy storage from glycogen in muscle, to fat. Chronic hepatalin suppression leads to a predictable chronology of dysfunctions, first diagnosable as Absence of Meal-induced Insulin Sensitization (AMIS) which progresses to prediabetes, adiposity, and type 2 diabetes. The focus on nutrient partitioning and the role of hepatalin allows AMIS to be diagnosed, prevented, and treated, including through the use of lifestyle interventions.
C1 [Lautt, W. Wayne] Univ Manitoba, Max Rady Fac Hlth Sci, Dept Pharmacol & Therapeut, 260 Brodie Ctr,727 McDermot Ave, Winnipeg, MB R3E 3P5, Canada.
C3 University of Manitoba
RP Lautt, WW (corresponding author), Univ Manitoba, Max Rady Fac Hlth Sci, Dept Pharmacol & Therapeut, 260 Brodie Ctr,727 McDermot Ave, Winnipeg, MB R3E 3P5, Canada.
EM wayne.Lautt@scimar.ca
RI Lautt, W./AAC-6106-2021
OI Lautt, W. Wayne/0000-0002-7239-1798
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NR 124
TC 0
Z9 0
U1 0
U2 3
PU CANADIAN SCIENCE PUBLISHING
PI OTTAWA
PA 123 Slater Street, Suite 610, OTTAWA, ON K1P 5H2, CANADA
SN 0008-4212
EI 1205-7541
J9 CAN J PHYSIOL PHARM
JI Can. J. Physiol. Pharmacol.
PD MAR
PY 2023
VL 101
IS 3
BP 117
EP 135
DI 10.1139/cjpp-2022-0332117
PG 19
WC Pharmacology & Pharmacy; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Physiology
GA H0AU5
UT WOS:000992686000001
PM 36716439
DA 2025-06-11
ER

PT J
AU Waheed, N
   Elias-Smale, S
   Malas, W
   Maas, AH
   Sedlak, TL
   Tremmel, J
   Mehta, PK
AF Waheed, Nida
   Elias-Smale, Suzette
   Malas, Waddah
   Maas, Angela H.
   Sedlak, Tara L.
   Tremmel, Jennifer
   Mehta, Puja K.
TI Sex differences in non-obstructive coronary artery disease
SO CARDIOVASCULAR RESEARCH
LA English
DT Review
DE Coronary microvascular dysfunction; Angina; Women
ID CARDIOVASCULAR RISK-FACTORS; POLYCYSTIC-OVARY-SYNDROME; CARDIAC
   SYNDROME-X; TERM-FOLLOW-UP; MICROVASCULAR DYSFUNCTION; CHEST-PAIN;
   MYOCARDIAL-INFARCTION; NATIONAL-HEART; ENDOTHELIAL DYSFUNCTION;
   DIAGNOSTIC-CRITERIA
AB Ischaemic heart disease is a leading cause of morbidity and mortality in both women and men. Compared with men, symptomatic women who are suspected of having myocardial ischaemia are more likely to have no obstructive coronary artery disease (CAD) on coronary angiography. Coronary vasomotor disorders and coronary microvascular dysfunction (CMD) have been increasingly recognized as important contributors to angina and adverse outcomes in patients with no obstructive CAD. CMD from functional and structural abnormalities in the microvasculature is associated with adverse cardiac events and mortality in both sexes. Women may be particularly susceptible to vasomotor disorders and CMD due to unique factors such as inflammation, mental stress, autonomic, and neuroendocrine dysfunction, which predispose to endothelial dysfunction and CMD. CMD can be detected with coronary reactivity testing and non-invasive imaging modalities; however, it remains underdiagnosed. This review focuses on sex differences in presentation, pathophysiologic risk factors, diagnostic testing, and prognosis of CMD.
C1 [Waheed, Nida] Univ Florida, Dept Med, Gainesville, FL USA.
   [Elias-Smale, Suzette; Maas, Angela H.] Radboud Univ Nijmegen, Dept Cardiol, Med Ctr, Nijmegen, Netherlands.
   [Malas, Waddah; Mehta, Puja K.] Emory Univ, Emory Womens Heart Ctr, Dept Med, Div Cardiol, 1462 Clifton Rd,Suite 505, Atlanta, GA 30329 USA.
   [Sedlak, Tara L.] Univ British Columbia, Leslie Diamond Womens Heart Ctr, Vancouver, BC, Canada.
   [Tremmel, Jennifer] Stanford Univ, Dept Med, Div Cardiovasc Med, Stanford, CA 94305 USA.
C3 State University System of Florida; University of Florida; Radboud
   University Nijmegen; Emory University; University of British Columbia;
   Stanford University
RP Mehta, PK (corresponding author), Emory Univ, Emory Womens Heart Ctr, Dept Med, Div Cardiol, 1462 Clifton Rd,Suite 505, Atlanta, GA 30329 USA.
EM pkmehta@emory.edu
RI Waheed, Nida/AAM-6077-2020; Elias-Smale, Suzette/F-2410-2014
OI Mehta, Puja/0000-0002-5678-812X
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NR 173
TC 69
Z9 77
U1 0
U2 9
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0008-6363
EI 1755-3245
J9 CARDIOVASC RES
JI Cardiovasc. Res.
PD MAR 15
PY 2020
VL 116
IS 4
BP 829
EP 840
DI 10.1093/cvr/cvaa001
PG 12
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA LJ0MI
UT WOS:000529868100008
PM 31958135
OA Bronze
DA 2025-06-11
ER

PT J
AU Walsh, JJ
   Neudorf, H
   Little, JP
AF Walsh, Jeremy J.
   Neudorf, Helena
   Little, Jonathan P.
TI 14-Day Ketone Supplementation Lowers Glucose and Improves Vascular
   Function in Obesity: A Randomized Crossover Trial
SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Article
DE beta-hydroxybutyrate; glucose-lowering; flow-mediated dilation; NLRP3
   inflammasome; inflammation; postprandial glucose
ID BETA-HYDROXYBUTYRATE; OXIDATIVE STRESS; NLRP3 INFLAMMASOME; FATTY-ACIDS;
   HEALTHY; SUPPRESSION; PERFORMANCE; EXERCISE; MUSCLE; ICAM-1
AB Context: Postprandial hyperglycemia increases systemic inflammation and is a risk factor for cardiovascular disease. A ketone monoester (KME) drink containing beta-hydroxybutyrate (beta-OHB) rapidly lowers plasma glucose, which may be a strategy protecting against postprandial hyperglycemia.
   Objective: We hypothesized that KME would attenuate 2-hour postprandial glucose, lower systemic inflammation, and improve vascular function in adults with obesity.
   Methods: In a randomized crossover design, 14 participants with obesity (age = 56 +/- 12 years; body mass index = 32.8 +/- 7.7 kg/m(2)) consumed KME (12 g beta-OHB) or placebo 15 minutes prior to each meal for 14 days with all meals provided and matched between conditions. Postprandial glycemia was assessed by continuous glucose monitoring. Vascular function and inflammation were assessed before and after treatment periods.
   Results: Postprandial glucose was 8.0% lower in KME versus placebo (g = 0.735; P = 0.011) and 24-hour average glucose reduced by 7.8% (g = 0.686; P = 0.0001). Brachial artery flow-mediated dilation increased from 6.2 +/- 1.5% to 8.9 +/- 3.3% in KME (g = 1.05; P = 0.0004) with no changes in placebo (condition x time interaction, P = 0.004). There were no changes in plasma cytokines; however, lipopolysaccharide-stimulated monocyte caspase-1 activation was lower following KME supplementation versus placebo (stimulation x condition x time interaction; P = 0.004). The KME supplement was well tolerated by participants and adherence to the supplementation regimen was very high.
   Conclusions: In adults with obesity, 14 days of premeal KME supplementation improves glucose control, enhances vascular function, and may reduce cellular inflammation. KME supplementation may be a viable, nonpharmacological approach to improving and protecting vascular health in people with heightened cardiometabolic risk.
C1 [Walsh, Jeremy J.; Neudorf, Helena; Little, Jonathan P.] Univ British Columbia Okanagan, Exercise Metab & Inflammat Lab, Kelowna, BC V1V 1V7, Canada.
   [Walsh, Jeremy J.] McMaster Univ, Dept Kinesiol, Hamilton, ON L8S 4K1, Canada.
C3 University of British Columbia; University of British Columbia Okanagan;
   McMaster University
RP Little, JP (corresponding author), Univ British Columbia Okanagan, 1147 Res Rd, Kelowna, BC V1V 1V7, Canada.
EM jonathan.little@ubc.ca
RI Little, Jonathan/T-4076-2019
OI Neudorf, Helena/0000-0002-8051-1542; Little,
   Jonathan/0000-0002-9796-2008; Walsh, Jeremy/0000-0003-1782-7074
FU Heart and Stroke Foundation [G-17-0018639]; Canadian Institutes of
   Health Research (CIHR) New Investigator Salary Award [MSH-141980];
   Michael Smith Foundation for Health Research (MSFHR) Scholar Award
   [16890]; MSFHR Fellowship Award [17941]
FX The trial was funded by a Heart and Stroke Foundation Grant-in-Aid
   (G-17-0018639). J.L is supported by a Canadian Institutes of Health
   Research (CIHR) New Investigator Salary Award (MSH-141980) and a Michael
   Smith Foundation for Health Research (MSFHR) Scholar Award (16890). J.W
   was supported by a MSFHR Fellowship Award (17941).
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NR 55
TC 34
Z9 35
U1 0
U2 6
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0021-972X
EI 1945-7197
J9 J CLIN ENDOCR METAB
JI J. Clin. Endocrinol. Metab.
PD APR
PY 2021
VL 106
IS 4
BP E1738
EP E1754
DI 10.1210/clinem/dgaa925
PG 17
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA RZ9LF
UT WOS:000648919200022
PM 33367782
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Elshorbagy, AK
   Valdivia-Garcia, M
   Refsum, H
   Butte, N
AF Elshorbagy, Amany K.
   Valdivia-Garcia, Maria
   Refsum, Helga
   Butte, Nancy
TI The Association of Cysteine with Obesity, Inflammatory Cytokines and
   Insulin Resistance in Hispanic Children and Adolescents
SO PLOS ONE
LA English
DT Article
ID HOMOCYSTEINE S-METHYLTRANSFERASE; BODY-COMPOSITION; ENERGY-EXPENDITURE;
   OXIDATIVE STRESS; ADIPOSE-TISSUE; HORDALAND HOMOCYSTEINE; METHIONINE
   RESTRICTION; LIPID-METABOLISM; DEFICIENT MICE; RISK
AB Context: Plasma total cysteine (tCys) independently relates to fat mass in adults. Dietary cyst(e)ine promotes adiposity and decreases glucose tolerance in some rodent models, but alleviates insulin resistance in others.
   Objective: To investigate whether the association of tCys with body fat extends to children at particular risk of obesity, and whether tCys is associated with insulin resistance and obesity-associated inflammation.
   Methods: We explored the cross-sectional relations of fasting plasma tCys and related metabolites with body composition measured by dual-energy X-ray absorptiometry in 984 Hispanic children and adolescents aged 4-19 years from the Viva La Familia Study. Linear and logistic regression and dose-response curves were used to evaluate relations of tCys with obesity, insulin resistance and inflammatory markers including interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), monocyte chemoattractant protein-1 (MCP-1) and C-reactive protein (CRP).
   Results: tCys, methionine and total homocysteine (tHcy) increased with age. Upper tCys quartile was independently associated with a 5-fold increased risk of obesity (95% CI 3.5-8.0, P<0.001), and 2-fold risk of insulin resistance (95% CI: 1.6-5.0, P<0.001; adjusted for body fat%). Within the overweight/obese subgroup, but not in normal-weight children, tCys accounted for 9% of the variability in body fat% (partial r = 0.30, P<0.001; adjusted for age and gender). tCys correlated positively with serum non-esterified fatty acids and leptin, partly independent of body fat, but was not associated with serum IL-6, TNF-alpha or MCP-1. A positive correlation with CRP disappeared after adjustment for BMI.
   Conclusion: tCys is independently associated with obesity and insulin resistance in Hispanic children and adolescents, highlighting a previously underappreciated link between the sulfur amino acid metabolic pathway and obesity and cardiometabolic risk.
C1 [Elshorbagy, Amany K.; Valdivia-Garcia, Maria; Refsum, Helga] Univ Oxford, Dept Pharmacol, Oxford OX1 3QT, England.
   [Elshorbagy, Amany K.] Univ Alexandria, Fac Med, Dept Physiol, Alexandria, Egypt.
   [Refsum, Helga] Univ Oslo, Inst Basic Med Sci, Dept Nutr, Oslo, Norway.
   [Butte, Nancy] Baylor Coll Med, Dept Pediat, USDA ARS, Childrens Nutr Res Ctr, Houston, TX 77030 USA.
C3 University of Oxford; Egyptian Knowledge Bank (EKB); Alexandria
   University; University of Oslo; United States Department of Agriculture
   (USDA); Baylor College of Medicine
RP Elshorbagy, AK (corresponding author), Univ Oxford, Dept Pharmacol, S Parks Rd, Oxford OX1 3QT, England.
EM amany.elshorbagy@pharm.ox.ac.uk
RI Refsum, Helga/A-4073-2010; Elshorbagy, Amany/A-4117-2015
OI Elshorbagy, Amany/0000-0002-8624-860X
FU National Institutes of Health (NIH) [DK59264, DK080457]; USDA/ARS
   [6250-51000-053]; Research Council of Norway; Johan Throne Holst
   Foundation for Nutrition Research; Charles Wolfson Charitable Trust
FX This work was supported by the National Institutes of Health (NIH)
   [DK59264, DK080457], and the USDA/ARS [Cooperative Agreement
   6250-51000-053]. This study has also received support from The Research
   Council of Norway, The Johan Throne Holst Foundation for Nutrition
   Research and the Charles Wolfson Charitable Trust. The funders had no
   role in study design, data collection and analysis, decision to publish,
   or preparation of the manuscript.
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NR 46
TC 59
Z9 64
U1 0
U2 10
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD SEP 11
PY 2012
VL 7
IS 9
AR e44166
DI 10.1371/journal.pone.0044166
PG 8
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 003VE
UT WOS:000308638700047
PM 22984471
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Fallah, M
   Azad, BJ
   Najafi, A
   Esmaeily, Z
   Balighi, K
   Daneshpazhooh, M
   Ebrahimpour-Koujan, S
AF Fallah, Maryam
   Azad, Banafsheh Jafari
   Najafi, Anahita
   Esmaeily, Zahra
   Balighi, Kamran
   Daneshpazhooh, Maryam
   Ebrahimpour-Koujan, Soraiya
TI High dietary acid load predicts severity of autoimmune skin disease: a
   cross-sectional study
SO SCIENTIFIC REPORTS
LA English
DT Article
DE Pemphigus Vulgaris; Dietary acid load; DAL; PRAL; NEAP; PDAI
ID CARDIOMETABOLIC RISK-FACTORS; DISORDER INTENSITY SCORE;
   PEMPHIGUS-VULGARIS; OXIDATIVE STRESS; BASE LOAD; AREA INDEX; EXCRETION;
   VALIDITY; PATHOGENESIS; ASSOCIATION
AB No previous study has examined the association of an acid-base imbalanced diet to autoimmune bullous disease. The present study aimed to investigate the association between dietary acid load (DAL) as either potential renal acid load (PRAL) and net endogenous acid production (NEAP) intake on the odds of high-severity Pemphigus Vulgaris (PV) disease in adult Iranian patients to fill this gap. A cross-sectional study was conducted on 138 patients, aged 18-65 years with confirmed diagnoses of PV in a referral university center for autoimmune bullous diseases. The dietary intakes of all patients during the last year before enrollment in the study were assessed using a 168-item semi-quantitative food frequency questionnaire. Dietary acid load was calculated based on the PRAL and NEAP scores. To assess PV severity, the pemphigus disease area index (PDAI) score was used. Logistic regression was used to evaluate the association between DAL and PDAI. A positive association was observed between PRAL and PDAI score in the crude (adjusted R-2 = 0.088, B = 6.88, P < 0.0001) and all other adjusted models, as well as the crude model for NEAP (adjusted R-2 = 0.037, B = 4.72, P = 0.013). In terms of adherence to NEAP and PRAL, those in the top tertile of PRAL and NEAP had a higher vulnerability for severe PV in unadjusted (OR = 5.18, 95% (CI) 2.19-12.25) and (OR = 2.48, 95% (CI) 1.08-5.68) respectively. In the present study, we found a significant direct association between DAL and severity of disease in PV patients. Further studies are required to confirm these findings.
C1 [Fallah, Maryam; Ebrahimpour-Koujan, Soraiya] Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Clin Nutr, POB 14155-6117 44,Hojjat Dost Alley,Naderi St,Kesh, Tehran, Iran.
   [Azad, Banafsheh Jafari] Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Cellular & Mol Nutr, Tehran, Iran.
   [Najafi, Anahita] Univ Tehran Med Sci, Sch Med, Tehran, Iran.
   [Esmaeily, Zahra] Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Community Nutr, Tehran, Iran.
   [Balighi, Kamran; Daneshpazhooh, Maryam] Univ Tehran Med Sci, Autoimmune Bullous Dis Res Ctr, Tehran, Iran.
   [Balighi, Kamran; Daneshpazhooh, Maryam] Univ Tehran Med Sci, Razi Hosp, Dept Dermatol, Tehran, Iran.
   [Ebrahimpour-Koujan, Soraiya] Univ Tehran Med Sci, Canc Inst, Canc Res Ctr, Tehran, Iran.
C3 Tehran University of Medical Sciences; Tehran University of Medical
   Sciences; Tehran University of Medical Sciences; Tehran University of
   Medical Sciences; Tehran University of Medical Sciences; Tehran
   University of Medical Sciences; Razi Hospital; Tehran University of
   Medical Sciences
RP Ebrahimpour-Koujan, S (corresponding author), Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Clin Nutr, POB 14155-6117 44,Hojjat Dost Alley,Naderi St,Kesh, Tehran, Iran.; Ebrahimpour-Koujan, S (corresponding author), Univ Tehran Med Sci, Canc Inst, Canc Res Ctr, Tehran, Iran.
EM nutri.seam1@gmail.com
RI Ebrahimpour-kujan, Soraiya/E-4087-2018
FU Tehran University of Medical sciences, Tehran, Iran
FX All Study was supported by the Tehran University of Medical sciences,
   Tehran, Iran. The authors would also like to thank all patients who took
   part in this study.
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NR 92
TC 0
Z9 0
U1 0
U2 0
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD DEC 4
PY 2024
VL 14
IS 1
AR 30257
DI 10.1038/s41598-024-78709-4
PG 12
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA O6Y0B
UT WOS:001372544400038
PM 39632914
OA gold
DA 2025-06-11
ER

PT J
AU Zisis, M
   Chondrogianni, ME
   Androutsakos, T
   Rantos, I
   Oikonomou, E
   Chatzigeorgiou, A
   Kassi, E
AF Zisis, Marios
   Chondrogianni, Maria Eleni
   Androutsakos, Theodoros
   Rantos, Ilias
   Oikonomou, Evangelos
   Chatzigeorgiou, Antonios
   Kassi, Eva
TI Linking Cardiovascular Disease and Metabolic Dysfunction-Associated
   Steatotic Liver Disease (MASLD): The Role of Cardiometabolic Drugs in
   MASLD Treatment
SO BIOMOLECULES
LA English
DT Review
DE anti-diabetic drugs; anti-hypertensive drugs; hypolipidemic agents;
   MASH; MASLD; NAFLD; resmetirom
ID TYPE-2 DIABETES-MELLITUS; GROWTH-FACTOR 21; LEFT-VENTRICULAR
   DYSFUNCTION; ANGIOPOIETIN-LIKE PROTEINS; EPICARDIAL ADIPOSE-TISSUE;
   PLACEBO-CONTROLLED TRIAL; EXOME-WIDE ASSOCIATION;
   CORONARY-HEART-DISEASE; CIRCULATING FETUIN-A; FATTY LIVER
AB The link between cardiovascular disease (CVD) and metabolic dysfunction-associated steatotic liver disease (MASLD) is well-established at both the epidemiological and pathophysiological levels. Among the common pathophysiological mechanisms involved in the development and progression of both diseases, oxidative stress and inflammation, insulin resistance, lipid metabolism deterioration, hepatokines, and gut dysbiosis along with genetic factors have been recognized to play a pivotal role. Pharmacologic interventions with drugs targeting common modifiable cardiometabolic risk factors, such as T2DM, dyslipidemia, and hypertension, are a reasonable strategy to prevent CVD development and progression of MASLD. Recently, a novel drug for metabolic dysfunction-associated steatohepatitis (MASH), resmetirom, has shown positive effects regarding CVD risk, opening new opportunities for the therapeutic approach of MASLD and CVD. This review provides current knowledge on the epidemiologic association of MASLD to CVD morbidity and mortality and enlightens the possible underlying pathophysiologic mechanisms linking MASLD with CVD. The role of cardiometabolic drugs such as anti-hypertensive drugs, hypolipidemic agents, glucose-lowering medications, acetylsalicylic acid, and the thyroid hormone receptor-beta agonist in the progression of MASLD is also discussed. Metformin failed to prove beneficial effects in MASLD progression. Studies on the administration of thiazolinediones in MASLD suggest effectiveness in improving steatosis, steatohepatitis, and fibrosis, while newer categories of glucose-lowering agents such as GLP-1Ra and SGLT-2i are currently being tested for their efficacy across the whole spectrum of MASLD. Statins alone or in combination with ezetimibe have yielded promising results. The conduction of long-duration, large, high-quality, randomized-controlled trials aiming to assess by biopsy the efficacy of cardiometabolic drugs to reverse MASLD progression is of great importance.
C1 [Zisis, Marios; Rantos, Ilias] Natl & Kapodistrian Univ Athens, Med Sch, Mikras Asias 75, Athens 11527, Greece.
   [Chondrogianni, Maria Eleni; Kassi, Eva] Natl & Kapodistrian Univ Athens, Med Sch, Dept Biol Chem, Athens 11527, Greece.
   [Chondrogianni, Maria Eleni; Kassi, Eva] Natl & Kapodistrian Univ Athens, Laiko Hosp, Dept Propaedeut & Internal Med 1, Endocrine Unit, Athens 11527, Greece.
   [Androutsakos, Theodoros] Natl & Kapodistrian Univ Athens, Med Sch, Dept Pathophysiol, 75 Mikras Asias Str, Athens 11527, Greece.
   [Oikonomou, Evangelos] Univ Athens, Sotiria Thorac Dis Hosp Athens, Med Sch, Dept Cardiol 3, Athens 11527, Greece.
   [Chatzigeorgiou, Antonios] Natl & Kapodistrian Univ Athens, Med Sch, Dept Physiol, 75 Mikras Asias Str, Athens 11527, Greece.
C3 National & Kapodistrian University of Athens; National & Kapodistrian
   University of Athens; Laiko General Hospital; National & Kapodistrian
   University of Athens; National & Kapodistrian University of Athens;
   National & Kapodistrian University of Athens; National & Kapodistrian
   University of Athens
RP Kassi, E (corresponding author), Natl & Kapodistrian Univ Athens, Med Sch, Dept Biol Chem, Athens 11527, Greece.; Kassi, E (corresponding author), Natl & Kapodistrian Univ Athens, Laiko Hosp, Dept Propaedeut & Internal Med 1, Endocrine Unit, Athens 11527, Greece.
EM mzisis01@gmail.com; marielena.hondr@gmail.com; t_androutsakos@yahoo.gr;
   heliasrantos88@gmail.com; boikono@gmail.com; achatzig@med.uoa.gr;
   ekassi@med.uoa.gr
RI Chatzigeorgiou, Antonios/G-1581-2010; Androutsakos,
   Theodoros/AAF-5209-2020
OI Chatzigeorgiou, Antonios/0000-0002-7039-4223; Oikonomou,
   Evangelos/0000-0001-8079-0599; Androutsakos,
   Theodoros/0000-0003-2556-6230
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NR 269
TC 1
Z9 1
U1 0
U2 0
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2218-273X
J9 BIOMOLECULES
JI Biomolecules
PD FEB 23
PY 2025
VL 15
IS 3
AR 324
DI 10.3390/biom15030324
PG 37
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 0PQ9Q
UT WOS:001453036700001
PM 40149860
OA gold
DA 2025-06-11
ER

PT J
AU Guscoth, LB
   Appleton, SL
   Martin, SA
   Adams, RJ
   Melaku, YA
   Wittert, GA
AF Guscoth, Layla B.
   Appleton, Sarah L.
   Martin, Sean A.
   Adams, Robert J.
   Melaku, Yohannes A.
   Wittert, Gary A.
TI The Association of Obstructive Sleep Apnea and Nocturnal Hypoxemia with
   Lipid Profiles in a Population-Based Study of Community-Dwelling
   Australian Men
SO NATURE AND SCIENCE OF SLEEP
LA English
DT Article
DE obstructive sleep apnea; triglycerides; hypoxemia; cohort studies; men;
   visceral obesity
ID CARDIOVASCULAR-DISEASE RISK; REM-SLEEP; DIETARY PATTERNS; COHORT;
   HYPERTENSION; OBESITY; PREVALENCE; INSTRUMENT; METABOLISM; MECHANISMS
AB Objective: To determine the association of obstructive sleep apnea and nocturnal hypoxemia with serum lipid profiles in unselected community-dwelling men.
   Methods: Cross-sectional data from participants of the Men Androgen Inflammation Lifestyle Environment and Stress (MAILES) study (n=753) who underwent full in-home polysomnography (Embletta X100) was used. Triglycerides, high- (HDL), low-density lipoprotein (LDL), and total cholesterol were assessed on a fasting morning blood sample. Multivariable linear regression analyses assessed associations between lipids and continuous measures of nocturnal hypoxemia (oxygen desaturation index (3%) (ODI), apnea-hypopnea index (AHI), and rapid eye movement sleep apnea-hypopnea index (REM-AHI)), adjusted for chronic conditions, risk behavior and sociodemographic factors. Sensitivity analyses examined the effect of lipid lowering therapies on reported estimates. Effect modification was examined through stratification by waist circumference groups.
   Results: In 753 participants with mean (SD) age of 60.8 (10.9) years and waist circumference: 99.3 (11.6) cm, the prevalence of OSA (AH1>10) was 52.6%. Overall, no significant associations between OSA metrics and lipid measures were found. Similarly, sensitivity analysis excluding lipid lowering therapies showed no significant associations. In analysis stratified by waist circumference (<95cm, 95-100cm, >100cm), ODI (3%, unstandardized B: 0.027, 95% CI: 0.015-0.040), AHI (0.023, 0.012-0.033) and AHIREM (0.012, 0.001-0.022) were positively associated with serum triglycerides in participants with a normal waist circumference (<95cm).
   Conclusion: Obstructive sleep apnea metrics were positively associated with serum triglyceride levels in men with a normal waist circumference. Healthy weight individuals with OSA require clinical attention to improve cardiometabolic risk profiles.
C1 [Guscoth, Layla B.; Martin, Sean A.; Wittert, Gary A.] Univ Adelaide, South Australian Hlth & Med Res Inst, Freemasons Ctr Male Hlth & Well Being, Adelaide, SA, Australia.
   [Guscoth, Layla B.; Martin, Sean A.; Wittert, Gary A.] Univ Adelaide, Fac Hlth & Med Sci, Adelaide, SA, Australia.
   [Appleton, Sarah L.; Adams, Robert J.; Melaku, Yohannes A.] Flinders Univ S Australia, Flinders Hlth & Med Res Inst, Sleep Hlth, Flinders Ctr Res Excellence, Adelaide, SA 5042, Australia.
C3 South Australian Health & Medical Research Institute (SAHMRI);
   University of Adelaide; University of Adelaide; Flinders University
   South Australia
RP Appleton, SL (corresponding author), Flinders Univ S Australia, Flinders Hlth & Med Res Inst, Sleep Hlth, Flinders Ctr Res Excellence, Adelaide, SA 5042, Australia.
EM sarah.appleton@flinders.edu.au
RI Adams, Robert/GPW-8528-2022; Melaku, Yohannes/S-2451-2019; Appleton,
   Sarah/Y-5206-2019; wittert, gary/AAE-2398-2019; Appleton,
   Sarah/E-9149-2017
OI Appleton, Sarah/0000-0001-7292-9714
FU National Health and Medical Research Council of Australia [627227];
   Hospital Research Foundation; ResMed Foundation
FX This work was supported by a National Health and Medical Research
   Council of Australia Project Grant (627227) , the Hospital Research
   Foundation and ResMed Foundation.
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NR 64
TC 14
Z9 14
U1 1
U2 17
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1179-1608
J9 NAT SCI SLEEP
JI NAT. SCI. SLEEP
PY 2021
VL 13
BP 1771
EP 1782
DI 10.2147/NSS.S327478
PG 12
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology
GA WG6NT
UT WOS:000707111600002
PM 34675725
OA Green Published
DA 2025-06-11
ER

PT J
AU Bailey, DP
   Locke, CD
AF Bailey, Daniel P.
   Locke, Christopher D.
TI Breaking up prolonged sitting with light-intensity walking improves
   postprandial glycemia, but breaking up sitting with standing does not
SO JOURNAL OF SCIENCE AND MEDICINE IN SPORT
LA English
DT Article
DE Exercise; Blood glucose; Sedentary lifestyle; Postprandial period
ID CARDIOVASCULAR-DISEASE; MODERATE EXERCISE; OXIDATIVE STRESS;
   SKELETAL-MUSCLE; SEDENTARY TIME; GLUCOSE; HYPERGLYCEMIA; RISK;
   INGESTION; RESPONSES
AB Objectives: To explore the effects of breaking up prolonged sitting time with standing or light-intensity walking on a range of cardiometabolic risk markers.
   Design: A randomised three-period, three-treatment acute crossover trial.
   Methods: Ten non-obese adults took part in three trials: (1) uninterrupted sitting; (2) seated with 2-min bouts of standing every 20 min; and (3) seated with 2-min bouts of light-intensity walking every 20 min. Two standardised test drinks (total 80.3 carbohydrate, 50g fat) were provided after an initial 1-h period of uninterrupted sitting. Plasma glucose and blood pressure were assessed hourly to calculate area under the curve. Total cholesterol, HDL, and triglycerides were assessed at baseline and 5-h. ANOVAs were used to explore between-trial differences.
   Results: Glucose area under the curve was lower in the activity-break condition compared to the uninterrupted sitting and standing-break conditions: mean area under the curve 18.5(95% CI 17,20), 22.0 (20.5, 23.5), and 22.2 (20.7, 23.7) mmol L/5-h, respectively, p < 0.001; no difference between uninterrupted sitting and standing-break conditions (p > 0.05). Systolic and diastolic blood pressure area under the curve did not differ significantly between conditions, nor did responses in lipid parameters (p > 0.05).
   Conclusions: This study suggests that interrupting sitting time with frequent brief bouts of light-intensity activity, but not standing, imparts beneficial postprandial responses that may enhance cardiometabolic health. These findings may have importance in the design of effective interventions to reduce cardiometabolic disease risk. (C) 2014 Sports Medicine Australia. Published by Elsevier Ltd. All rights reserved.
C1 [Bailey, Daniel P.; Locke, Christopher D.] Univ Bedfordshire, Inst Sport & Phys Act Res, Dept Sport Sci & Phys Act, Luton, Beds, England.
C3 University of Bedfordshire
RP Bailey, DP (corresponding author), Univ Bedfordshire, Inst Sport & Phys Act Res, Dept Sport Sci & Phys Act, Luton, Beds, England.
EM daniel.bailey@beds.ac.uk
RI Bailey, Daniel/HDL-7697-2022
OI Bailey, Daniel/0000-0003-3772-630X
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NR 30
TC 267
Z9 304
U1 2
U2 91
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1440-2440
EI 1878-1861
J9 J SCI MED SPORT
JI J. Sci. Med. Sport
PD MAY
PY 2015
VL 18
IS 3
BP 294
EP 298
DI 10.1016/j.jsams.2014.03.008
PG 5
WC Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Sport Sciences
GA CH4MS
UT WOS:000354008200012
PM 24704421
OA Green Submitted
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Maukonen, M
   Kanerva, N
   Partonen, T
   Männistö, S
AF Maukonen, Mirkka
   Kanerva, Noora
   Partonen, Timo
   Mannisto, Satu
TI Chronotype and energy intake timing in relation to changes in
   anthropometrics: a 7-year follow-up study in adults
SO CHRONOBIOLOGY INTERNATIONAL
LA English
DT Article
DE Diet; diurnal; circadian; food intake timing; food patterns; meal
   timing; obesity; weight change
ID WEIGHT CHANGE; FOOD-INTAKE; CIRCADIAN VARIATION; PHYSICAL-ACTIVITY;
   CALORIC-INTAKE; SOCIAL JETLAG; SLEEP; RISK; ASSOCIATIONS; TIME
AB u Individuals with a later preference for the daily activities (evening types) tend to have unhealthier behaviors, which could increase their risk for obesity when compared those with an earlier preference (morning types). Furthermore, later food intake timing, another behavior more characteristic of evening types, has been associated with obesity. However, chronotype differences in the long-term weight change and the role of chronotype in the association between energy intake timing and obesity risk are not clear. To study this we first examined the independent associations of chronotype and energy intake timing with anthropometric changes and then whether chronotype modified the association between energy intake timing and obesity risk. Our data included 1097 Finns from DILGOM (DIetary Lifestyle and Genetic Determinants of Obesity and Metabolic syndrome) 2007 (baseline) and 2014 (follow-up) and from Findiet 2007. Chronotype was assessed with a shortened version of Horne and ostberg's morningness-eveningness questionnaire. Energy intake timing (as percentages of the total energy intake in the morning/evening) was assessed with 48-h dietary recalls. Weight, body mass index (BMI), and waist circumference were based on measured and self-reported values. Analysis of co-variance and multivariable logistic regression models were used for statistical analyses. Evening typed women had greater weight gain (+ 2.3 kg vs. + 0.3 kg, P = 0.016) and increase in BMI (0.7 kg/m(2) vs. -0.1 kg/m(2), P = 0.024) than morning typed women. After excluding participants with depression, these associations attenuated to non-significant. Compared to participants whose energy intake was proportionally lowest during evening, those with proportionally highest energy intake during evening were more likely with obesity (BMI >= 30 kg/m(2)) after follow-up (OR 1.97, 95% CI 1.21-3.21, Ptrend = 0.042). Participants' chronotype did not modify this association (Pinteract = 0.95). In conclusion, our findings indicated that evening energy intake may play a role in obesity regardless of the chronotype. Furthermore, evening typed women were more prone to increases in their anthropometrics, which seem to be at least partly explained by depression. Further studies of this topic are warranted.
C1 [Maukonen, Mirkka; Partonen, Timo; Mannisto, Satu] Natl Inst Hlth & Welf, Dept Publ Hlth Solut, Helsinki, Finland.
   [Maukonen, Mirkka; Kanerva, Noora] Univ Helsinki, Dept Publ Hlth, Helsinki, Finland.
C3 Finland National Institute for Health & Welfare; University of Helsinki
RP Maukonen, M (corresponding author), Natl Inst Hlth & Welf, POB 30, Helsinki 00271, Finland.
EM mirkka.maukonen@thl.fi
RI Partonen, Timo/G-1105-2012; Maukonen, Mirkka/G-9230-2018
OI Kanerva, Noora/0000-0001-6776-9357; Maukonen, Mirkka/0000-0002-2179-6904
FU Finnish Cultural foundation
FX MM was partly supported by the Finnish Cultural foundation.
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NR 48
TC 53
Z9 55
U1 0
U2 8
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 0742-0528
EI 1525-6073
J9 CHRONOBIOL INT
JI Chronobiol. Int.
PD JAN 2
PY 2019
VL 36
IS 1
BP 27
EP 41
DI 10.1080/07420528.2018.1515772
PG 15
WC Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics; Physiology
GA HF2NO
UT WOS:000454073500003
PM 30212231
DA 2025-06-11
ER

PT J
AU Feldman, SR
   Tian, HJ
   Gilloteau, I
   Mollon, P
   Shu, M
AF Feldman, Steven R.
   Tian, Haijun
   Gilloteau, Isabelle
   Mollon, Patrick
   Shu, Meng
TI Economic burden of comorbidities in psoriasis patients in the United
   States: results from a retrospective US database
SO BMC HEALTH SERVICES RESEARCH
LA English
DT Article
DE Psoriasis; Costs; Comorbidities
ID METABOLIC SYNDROME; PREVALENCE; HEALTH; RISK; METAANALYSIS; ASSOCIATION;
   DEPRESSION; ARTHRITIS; SEVERITY; ILLNESS
AB Background: Psoriasis is a multifactorial, inflammatory, skin disease associated with various comorbidities. The cost of those comorbidities is not well characterized. The present study assesses the incremental burden of comorbidities on healthcare resource utilization, direct costs and indirect costs associated with short-term disabilities among patients with psoriasis in the United States.
   Methods: A retrospective, U.S. cohort analysis was conducted using a large claims database. Adult psoriasis patients with at least two diagnoses of psoriasis during the years 2010 and 2011 (one psoriasis diagnosis had to happen in the year 2010) and with continuous enrollment of medical and pharmacy benefits in the years 2010 and 2011 were included. Psoriasis patients were categorized and compared according to the presence or absence of pre-selected comorbidities in the year 2010. Adjusted annual direct (costs associated with outpatient, emergency room, and inpatient claims, and outpatient pharmacy claims) and indirect costs (short-term disabilities) was assessed in patients with and without comorbidities using a regression analysis, controlling for age, gender, and psoriasis severity in year 2010.
   Results: In total, 56,406 patients (mean [SD]) age, 51.6 [14.6] years) were included in the analysis. The most prevalent comorbidities were hypertension (34.3%), hyperlipidemia (33.5%), cardiovascular disease (17.7%), diabetes (14.2%), and psoriatic arthritis (9.9%). Psoriasis patients with comorbidities used more healthcare resources than those without comorbidities. The incidence rate ratio (IRR) (95% CI) for patients with cardiovascular disease was 1.5 (1.4-1.5) for outpatient visits, 2.6 (2.4 - 2.8) for hospitalizations, and 2.3 (2.2 - 2.5) for ER visits, showing higher IRRs across all three types of resource use. The mean annual adjusted direct cost differences (i.e., incremental adjusted costs) in psoriasis patients with and without comorbidities were $9914.3, $8386.5, and $8275.1 for psoriatic arthritis, peripheral vascular disease, and cardiovascular disease, respectively. The mean annual incremental adjusted indirect costs of short-term disabilities were $1333, $1195, $994.9, and $996.6 for cerebrovascular disease, obesity, peripheral vascular disease, and depression, respectively.
   Conclusion: The presence of comorbidities was associated with higher healthcare resource utilization and costs among patients with psoriasis.
C1 [Feldman, Steven R.] Wake Forest Univ, Bowman Gray Sch Med, Dept Dermatol, 4618 Country Club Rd, Winston Salem, NC 27103 USA.
   [Tian, Haijun] Novartis Pharmaceut, E Hanover, NJ USA.
   [Gilloteau, Isabelle; Mollon, Patrick] Novartis Pharma AG, Basel, Switzerland.
   [Shu, Meng] Beijing Novartis Pharma Co Ltd, Beijing, Peoples R China.
C3 Wake Forest University; Wake Forest Baptist Medical Center; Novartis;
   Novartis USA; Novartis; Novartis; Novartis China
RP Gilloteau, I (corresponding author), Novartis Pharma AG, Basel, Switzerland.
EM isabelle.gilloteau@novartis.com
RI Feldman, Steven/AAH-6971-2021
FU Novartis Pharma AG Basel, Switzerland
FX The study was funded by Novartis Pharma AG Basel, Switzerland.
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NR 38
TC 43
Z9 46
U1 0
U2 2
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1472-6963
J9 BMC HEALTH SERV RES
JI BMC Health Serv. Res.
PD MAY 8
PY 2017
VL 17
AR 337
DI 10.1186/s12913-017-2278-0
PG 8
WC Health Care Sciences & Services
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Health Care Sciences & Services
GA EV6JK
UT WOS:000401875500004
PM 28482887
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU King, L
   Xia, LL
   Chen, J
   Li, WY
   Wang, Q
   Huang, Y
   Wang, P
   Liang, XL
   Li, YG
   Chen, LK
   Shan, ZL
   Peng, XL
   Liu, LG
AF King, Lei
   Xia, Lili
   Chen, Juan
   Li, Wanyi
   Wang, Qiang
   Huang, Yue
   Wang, Pei
   Liang, Xiaoling
   Li, Yonggang
   Chen, Liangkai
   Shan, Zhilei
   Peng, Xiaolin
   Liu, Liegang
TI Exposure to perchlorate and cardiovascular disease in China: A
   community-based cross-sectional study and benchmark dose estimation☆
SO ENVIRONMENTAL POLLUTION
LA English
DT Article
DE Perchlorate; Cardiovascular disease; Benchmark dose; Cross-sectional
   study
ID MITOCHONDRIAL OXIDATIVE STRESS; THYROID-HORMONE LEVELS; THIOCYANATE
   EXPOSURE; URINARY PERCHLORATE; INSULIN-SECRETION; NATIONAL-HEALTH;
   INDOOR DUST; RISK-FACTOR; NITRATE; WOMEN
AB The association between exposure to perchlorate, which inhibits thyroidal iodine uptake, and cardiovascular disease (CVD) is unclear in China. Moreover, the point of departure (POD) for perchlorate based on observed adverse health effect in Chinese populations remains absent. A total of 2355 adults (mean age 50.4 years and 39.2% male) from four communities in Shenzhen were included in analyses. Spot urine specimens were collected to measure urinary perchlorate concentrations, which were applied to estimate daily intakes of perchlorate. Multivariable logistic regression model was applied to examine the association between perchlorate and CVD. The roles of cardiometabolic risk factors, including obesity, abdominal obesity, hypertension, diabetes, and hyperlipidemia, were evaluated with mediation analyses. We further employed Bayesian benchmark dose (BMD) modeling to derive the POD for risk assessment. Comparing extreme tertiles, subjects in the highest perchlorate tertile had a significantly elevated risk of prevalent CVD (OR: 2.16; 95% CI: 1.28, 3.65). Multivariable-adjusted ORs for hypertension, diabetes, and hyperlipidemia associated with per doubling in urinary perchlorate concentration were 1.11 (95% CI: 1.01, 1.21), 1.15 (95% CI: 1.02, 1.28), and 1.11 (95% CI: 1.01, 1.20), respectively. Hypertension, diabetes, and hyperlipidemia partially mediated the perchlorate-CVD association (mediated proportion ranged from 7.75% to 11.30%). Given a benchmark response of 5% and 10%, the model-averaged BMD lower bounds (BMDLs) of perchlorate exposure on CVD were 0.15 and 0.40 mu g/kg-bw day, respectively. Our estimated POD for perchlorate was lower than those recommended by other groups. These findings call for stricter regulations on perchlorate contamination to promote cardiovascular health in China.
C1 [King, Lei; Xia, Lili; Chen, Juan; Li, Wanyi; Wang, Qiang; Huang, Yue; Wang, Pei; Liang, Xiaoling; Chen, Liangkai; Shan, Zhilei; Peng, Xiaolin; Liu, Liegang] Huazhong Univ Sci & Technol, Tongji Med Coll, Dept Nutr & Food Hyg, Sch Publ Hlth,Hubei Key Lab Food Nutr & Safety, Wuhan, Peoples R China.
   [King, Lei; Xia, Lili; Chen, Juan; Li, Wanyi; Wang, Qiang; Huang, Yue; Wang, Pei; Liang, Xiaoling; Chen, Liangkai; Shan, Zhilei; Peng, Xiaolin; Liu, Liegang] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Key Lab Environm & Hlth,Minist Educ, Wuhan, Peoples R China.
   [Li, Yonggang] Hubei Prov Ctr Dis Control & Prevent, Hubei Prov Key Lab Appl Toxicol, Wuhan, Peoples R China.
   [Peng, Xiaolin] Shenzhen Nanshan Ctr Chron Dis Control, Dept Noncommunicable Dis Prevent & Control, 6 Huaming Rd, Shenzhen 518051, Peoples R China.
C3 Huazhong University of Science & Technology; Huazhong University of
   Science & Technology; Ministry of Education - China; Shenzhen Nanshan
   Center for Chronic Disease Control
RP Peng, XL (corresponding author), Shenzhen Nanshan Ctr Chron Dis Control, Dept Noncommunicable Dis Prevent & Control, 6 Huaming Rd, Shenzhen 518051, Peoples R China.; Liu, LG (corresponding author), Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Dept Nutr & Food Hyg, 13 Hangkong Rd, Wuhan 430030, Peoples R China.
EM xiaolinpeng@hotmail.com; lgliu@mails.tjmu.edu.cn
RI Shan, Zhilei/S-5189-2019; 李, 万益/ISS-1769-2023; Chen,
   Liangkai/HSI-1304-2023
FU National Nature Science Foundation of China [82103850]; National Key
   Research and Development Program of China [2022YFA0806100]
FX This work was funded by the National Nature Science Foundation of China
   [grant number 82103850] and the National Key Research and Development
   Program of China [grant number 2022YFA0806100] . The funders had no role
   in study design; collection, analysis, and interpre-tation of data;
   writing of the report; the decision to submit the article for
   publication.
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NR 92
TC 0
Z9 0
U1 13
U2 13
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 0269-7491
EI 1873-6424
J9 ENVIRON POLLUT
JI Environ. Pollut.
PD FEB 1
PY 2025
VL 366
AR 125429
DI 10.1016/j.envpol.2024.125429
EA DEC 2024
PG 9
WC Environmental Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology
GA O9S8Y
UT WOS:001374446800001
PM 39617200
DA 2025-06-11
ER

PT J
AU Anjana, RM
   Nitika, S
   Jagannathan, N
   Vinothini, D
   Yuvarani, K
   Mohan, V
   Pradeepa, R
   Palmer, CNA
   O'Shea, M
   Goenka, S
   Manian, R
   Raj, AK
   Surendran, S
   Unnikrishnan, R
   Sallis, JF
   Ranjani, H
AF Anjana, Ranjit Mohan
   Nitika, Sharma
   Jagannathan, Narayanaswamy
   Vinothini, Deenadayalan
   Yuvarani, Kanniyappan
   Mohan, Viswanathan
   Pradeepa, Rajendra
   Palmer, Colin N. A.
   O'Shea, Melissa
   Goenka, Shifalika
   Manian, Ranjini
   Raj, Amrita Karthik
   Surendran, Shiny
   Unnikrishnan, Ranjit
   Sallis, James F.
   Ranjani, Harish
TI A Novel High-Intensity Short Interval Dance Intervention (THANDAV) for
   Non-Communicable Disease Prevention Tailored to Asian Indian Adolescent
   Girls
SO JOURNAL OF DIABETES SCIENCE AND TECHNOLOGY
LA English
DT Article; Early Access
DE adolescent girls; dance; diabetes; HIIT; physical activity; technology
ID GLUCOSE-INTOLERANCE; CHILDREN; ASSOCIATION; PREVALENCE
AB Background: A significant majority of adolescents from lower-middle-income countries do not meet recommendations for daily physical activity. THANDAV (Taking High-Intensity Interval Training [HIIT] ANd Dance to Adolescents for Victory over noncommunicable diseases [NCDs]) is a 10-minute dance intervention incorporating principles of HIIT. The present study evaluated the effect of THANDAV on cardiovascular risk factors and lifestyle behavior in Asian Indian adolescent girls.Methods: THANDAV was delivered as a 12-week pilot cluster randomized controlled trial (cRCT) in two schools, involving 108 schoolgirls aged 13 to 15 years in Chennai, India. The primary outcome was step counts, while secondary outcomes included metabolic, clinical, and lifestyle parameters. Focus group discussions and interviews were held to assess barriers to and acceptability of THANDAV intervention.Results: In the intention-to-treat analysis, the intervention group had significantly favorable changes in step counts (+1073 steps/day), skeletal muscle mass (+0.9 kg), body weight (-0.7 kg), body fat percentage (-2.0%), body mass index (-0.3 kg/m2), waist circumference (-1.0 cm), systolic (-4 mm Hg) and diastolic blood pressure (-4 mm Hg), resting heart rate (-3 bpm) and body fat mass (-1.7 kg), moderate -to-vigorous physical activity (+29.5 minutes/day), sleep (+46.4 minutes/day), sedentary time (-199.7 minutes/day), Adolescence Stress Scale (-6.6), and junk food consumption (-2.7) scores compared with controls. Qualitative interviews revealed that THANDAV routines were time-efficient, enjoyable, and easily fit into adolescents' busy schedules enabling feasible engagement in active leisure time.Conclusions: THANDAV is a culturally acceptable HIIT-based dance intervention that improves leisure-time physical activity and reduces cardiometabolic risk in Asian Indian adolescent girls.Trial Registration: The trial is registered with the Central Trials Registry-India (CTRI/2020/02/023384; URL: https://ctri.nic.in/Clinicaltrials/pmaindet2.php?EncHid=MzgyMTQ=&Enc=&userName=).
C1 [Anjana, Ranjit Mohan; Nitika, Sharma; Jagannathan, Narayanaswamy; Vinothini, Deenadayalan; Yuvarani, Kanniyappan; Mohan, Viswanathan; Pradeepa, Rajendra; Unnikrishnan, Ranjit] Madras Diabet Res Fdn, Chennai, India.
   [Anjana, Ranjit Mohan; Nitika, Sharma; Jagannathan, Narayanaswamy; Vinothini, Deenadayalan; Yuvarani, Kanniyappan; Mohan, Viswanathan; Pradeepa, Rajendra; Unnikrishnan, Ranjit; Ranjani, Harish] Dr Mohans Diabet Special Ctr, 4 Conran Smith Rd, Chennai 600086, India.
   [Palmer, Colin N. A.] Univ Dundee, Dundee, Scotland.
   [O'Shea, Melissa] Deakin Univ, Sch Psychol, Melbourne, Vic, Australia.
   [Goenka, Shifalika] Publ Hlth Fdn India, New Delhi, India.
   [Goenka, Shifalika] Ctr Chron Dis Control, New Delhi, India.
   [Manian, Ranjini] Championwoman Global Adjustments Fdn, Chennai, India.
   [Raj, Amrita Karthik] Seethapathy Clin & Hosp, Chennai, India.
   [Surendran, Shiny] Art Eating LLP, Chennai, India.
   [Sallis, James F.] Australian Catholic Univ, Melbourne, Vic, Australia.
   [Sallis, James F.] Univ Calif San Diego, Herbert Wertheim Sch Publ Hlth, La Jolla, CA USA.
   [Ranjani, Harish] Madras Diabet Res Fdn, Dept Prevent & Digital Hlth Res, 4 Conran Smith Rd, Chennai 600086, India.
C3 Madras Diabetes Research Foundation; University of Dundee; Deakin
   University; Public Health Foundation of India; Australian Catholic
   University; Australian Catholic University - Melbourne Campus;
   University of California System; University of California San Diego;
   Madras Diabetes Research Foundation
RP Anjana, RM; Ranjani, H (corresponding author), Dr Mohans Diabet Special Ctr, 4 Conran Smith Rd, Chennai 600086, India.; Ranjani, H (corresponding author), Madras Diabet Res Fdn, Dept Prevent & Digital Hlth Res, 4 Conran Smith Rd, Chennai 600086, India.
EM dranjana@drmohans.com; drranjanih@gmail.com
RI Pradeepa, Rajendra/ADN-8398-2022; O'Shea, Associate/KVX-7950-2024;
   Giussani, Giorgia/E-8057-2017
OI Mohan, Viswanathan/0000-0001-5038-6210
FU NIHR Global Health Research Centre for Multiple Long-Term Conditions
   using UK aid from the UK Government [NIHR203257]; National Institutes of
   Health Research (NIHR) [NIHR203257] Funding Source: National Institutes
   of Health Research (NIHR)
FX We extend our sincere gratitude to the students and administration of
   Sacred Heart Matriculation Higher Secondary School and Good Shepherd
   Matriculation Higher Secondary School, Chennai, India, for their
   participation and support in this study. We are also grateful to the
   THANDAV field team led by Mr Pandiyan for their efforts in ensuring the
   classes ran smoothly. We also thank the RAACK Dance Academy, Chennai,
   India who are our partners and were responsible for choreography,
   tutorials, and delivering THANDAV in school. SG is supported by NIHR
   Global Health Research Centre for Multiple Long-Term Conditions using UK
   aid from the UK Government (NIHR203257).
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   World health organization, 2020, WHO GUIDELINES PHYS
NR 40
TC 0
Z9 0
U1 0
U2 0
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1932-2968
J9 J DIABETES SCI TECHN
JI J. Diabetes Sci. Technol.
PD 2025 APR 21
PY 2025
DI 10.1177/19322968251332925
EA APR 2025
PG 16
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA 1PX8D
UT WOS:001470861500001
PM 40257233
DA 2025-06-11
ER

PT J
AU Narisada, A
   Shibata, E
   Hasegawa, T
   Masamura, N
   Taneda, C
   Suzuki, K
AF Narisada, Akihiko
   Shibata, Eiji
   Hasegawa, Tomomi
   Masamura, Nobue
   Taneda, Chitose
   Suzuki, Kohta
TI Sex differences in the association between fatty liver and type 2
   diabetes incidence in non-obese Japanese: A retrospective cohort study
SO JOURNAL OF DIABETES INVESTIGATION
LA English
DT Article
DE Asians; Metabolically healthy; Type&#160; 2 diabetes prevention
ID CARDIOMETABOLIC RISK PROFILE; BODY-MASS INDEX; ADIPOSE-TISSUE; WORK
   STRESS; BMI; MEN; CONSEQUENCES; ULTRASOUND; HEALTH; WHITES
AB Aims/Introduction Asians develop type 2 diabetes at a lower body mass index (BMI) compared with other races, which is partly because of Asian-specific fat depots. Sex plays a role in fat deposition, regardless of race. This retrospective cohort study aimed to investigate the association among fatty liver, sex and type 2 diabetes in non-obese Japanese.
   Materials and Methods The participants in this study (13,596 men and 6,037 women) were aged 30-64 years, and had undergone health checkups between 2013 and 2015, in Aichi, Japan. Baseline BMI was categorized as follows: <18.5, 18.5-19.9, 20-22.9, 23-24.9, 25-27.4 and >= 27.5 kg/m(2). Fatty liver was diagnosed by abdominal ultrasonography. The joint effect of BMI and fatty liver on the incidence of type 2 diabetes was assessed, stratified by sex.
   Results During follow up, 738 men and 138 women developed type 2 diabetes. Compared with the BMI of 20-22.9 kg/m(2) without fatty liver group, the BMI of 20-22.9 kg/m(2) with fatty liver was associated with a higher risk of type 2 diabetes in men, but not in women. Furthermore, men with a BMI of 23-24.9 and 25-27.4 kg/m(2) without fatty liver had no significant type 2 diabetes risk, whereas women with a BMI of 23-24.9 and 25-27.4 kg/m(2), regardless of fatty liver, had an increased risk.
   Conclusions These results suggest the association between fatty liver and type 2 diabetes in non-obese Asians is different by sex; fatty liver increases diabetes risk among male, not female, non-obese Asians.
C1 [Narisada, Akihiko; Suzuki, Kohta] Aichi Med Univ, Inst Occupat Hlth Sci, Nagakute, Aichi, Japan.
   [Shibata, Eiji; Suzuki, Kohta] Aichi Med Univ, Sch Med, Dept Hlth & Psychosocial Med, Nagakute, Aichi, Japan.
   [Hasegawa, Tomomi] Aichi Med Univ, Inst Phys Fitness Sports Med & Rehabil, Nagakute, Aichi, Japan.
   [Masamura, Nobue; Taneda, Chitose] Aichi Hlth Promot Fdn, Nagoya, Aichi, Japan.
C3 Aichi Medical University; Aichi Medical University; Aichi Medical
   University
RP Narisada, A (corresponding author), Aichi Med Univ, Inst Occupat Hlth Sci, Nagakute, Aichi, Japan.
EM akihikonarisada@yahoo.co.jp
OI Narisada, Akihiko/0000-0002-3957-6256
FU JPSP KAKENHI [JP19K17970]; Aichi Health Promotion Foundation [2019]
FX The authors thank Editage () for English language editing. The authors
   also thank Naoyoshi Kariya, Hidehito Tanaka and Yoshihiro Tsutsumi for
   advice on using the Aichi Health Promotion Study dataset. Finally, the
   authors thank Reiko Hori, Tomohiro Umemura, Masahiro Matsunaga, Iwao
   Okajima, Rei Wakayama and Fumio Kobayashi for their help with the
   discussion. This study was supported by grants from the JPSP KAKENHI
   (Grant Number JP19K17970) and Aichi Health Promotion Foundation (Grant
   Number 2019). The funders of the study had no role in study design, data
   collection, data analysis, data interpretation, writing of the report or
   the decision to submit the report for publication.
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NR 41
TC 7
Z9 7
U1 0
U2 12
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2040-1116
EI 2040-1124
J9 J DIABETES INVEST
JI J. Diabetes Investig.
PD AUG
PY 2021
VL 12
IS 8
BP 1480
EP 1489
DI 10.1111/jdi.13496
EA FEB 2021
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA TY0SO
UT WOS:000614339200001
PM 33411970
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Pérez, CM
   López-Cepero, A
   Almodóvar-Rivera, I
   Kiefe, CI
   Tucker, KL
   Person, SD
   Mattei, J
   Rodríguez-Orengo, J
   Rosal, MC
AF Perez, Cynthia M.
   Lopez-Cepero, Andrea
   Almodovar-Rivera, Israel
   Kiefe, Catarina I.
   Tucker, Katherine L.
   Person, Sharina D.
   Mattei, Josiemer
   Rodriguez-Orengo, Jose
   Rosal, Milagros C.
TI Cardiovascular Health Among Young Men and Women in Puerto Rico as
   Assessed by the Life's Essential 8 Metrics
SO JOURNAL OF THE AMERICAN HEART ASSOCIATION
LA English
DT Article
DE cardiovascular health; cardiovascular risk factors; Life's Essential 8;
   Puerto Rico; sex disparities; young adults
ID GENDER-DIFFERENCES; PHYSICAL-ACTIVITY; DIETARY-INTAKE; ADULTS;
   ASSOCIATIONS; PREVALENCE; VALIDATION; QUALITY; SEX
AB Background: Cardiovascular health (CVH) in young adulthood is associated with CVD in later life, yet CVH in young adults in the United States falls below ideal levels, with noticeable sex differences. Research on CVH in young adults in Puerto Rico is scarce. This study examined CVH and sex differences in CVH in a large cohort of young adults in Puerto Rico. Methods and Results: Data from 2162 Puerto Rican young adults aged 18 to 29 residing in PR were obtained from the PR-OUTLOOK (Puerto Rico Young Adults' Stress, Contextual, Behavioral, and Cardiometabolic Risk) study (2020-2023). Participants were recruited through various media and community outreach. CVH scores, graded on a 0 (worst) to 100 (best) scale, were derived from survey responses, physical exams, and laboratory assays. Linear regression with the margins postestimation command was used to determine adjusted means (95% CIs) for CVH scores by sex, controlling for age, marital status, education, childhood material deprivation, subjective social status, health insurance, and depressive symptoms. CVH was less than ideal (score<80) in 72.6% of the cohort (70.5% of women, 75.9% of men, P<0.05). Men had a significantly lower adjusted mean overall CVH score than women (70.7 versus 73.0) and lower adjusted mean scores for nicotine exposure (78.3 versus 86.7), non-high-density lipoprotein cholesterol (80.6 versus 86.4), and blood pressure (79.5 versus 92.2). Women had a significantly lower adjusted mean physical activity score compared with men (50.4 versus 59.5). Conclusions: Less-than-ideal CVH is notable among young adults, with men having worse CVH than women. These identified sex differences warrant further investigation and the design of interventions to enhance and preserve CVH.
C1 [Perez, Cynthia M.] Univ Puerto Rico, Grad Sch Publ Hlth, Dept Biostat & Epidemiol, Med Sci Campus,POB 365067, San Juan, PR 00936 USA.
   [Lopez-Cepero, Andrea] Emory Univ, Sch Publ Hlth, Dept Epidemiol, Atlanta, GA USA.
   [Almodovar-Rivera, Israel] Univ Puerto Rico, Coll Arts & Sci, Dept Math Sci, Mayaguez Campus, Mayaguez, PR USA.
   [Kiefe, Catarina I.; Person, Sharina D.] Univ Massachusetts, Chan Med Sch, Dept Populat & Quantitat Hlth Sci, Worcester, MA, Brazil.
   [Tucker, Katherine L.] Univ Massachusetts Lowell, Zuckerberg Coll Hlth Sci, Dept Biomed & Nutr Sci, Lowell, MA USA.
   [Mattei, Josiemer] Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA.
   [Rodriguez-Orengo, Jose] Univ Puerto Rico, Fdn Invest Clin Res, Sch Med, Dept Biochem, Med Sci Campus, San Juan, PR USA.
   [Rosal, Milagros C.] Univ Massachusetts, Chan Med Sch, Off Hlth Equ, Worcester, MA, Brazil.
   [Rosal, Milagros C.] Univ Massachusetts, Chan Med Sch, Dept Populat & Quantitat Hlth Sci, Worcester, MA, Brazil.
C3 University of Puerto Rico; University of Puerto Rico Medical Sciences
   Campus; Emory University; University of Puerto Rico; University of
   Puerto Rico Mayaguez; University of Massachusetts System; University of
   Massachusetts Lowell; Harvard University; Harvard T.H. Chan School of
   Public Health; University of Puerto Rico; University of Puerto Rico
   Medical Sciences Campus
RP Pérez, CM (corresponding author), Univ Puerto Rico, Grad Sch Publ Hlth, Dept Biostat & Epidemiol, Med Sci Campus,POB 365067, San Juan, PR 00936 USA.
EM cynthia.perez1@upr.edu
RI Tucker, Katherine/A-4545-2010; Mattei, Josiemer/H-1800-2016
OI Perez, Cynthia M./0000-0003-2529-7042; Tucker,
   Katherine/0000-0001-7640-662X; Mattei, Josiemer/0000-0001-5424-8245;
   Person, Sharina/0000-0001-9121-9566
FU National Heart, Lung, and Blood Institute [R01HL149119]; Hispanic
   Alliance for Clinical and Translational Research (Alliance) through the
   National Institute of General Medical Sciences [U54GM133807-05S1]
FX This research was supported by the National Heart, Lung, and Blood
   Institute (grant R01HL149119 to MCR and CMP). The research was also
   supported by the Hispanic Alliance for Clinical and Translational
   Research (Alliance) funding awarded through the National Institute of
   General Medical Sciences (U54GM133807-05S1). PR- OUTLOOK thanks the
   partner clinics, research center staff, and study participants. The
   funding agency played no role in the study's design, data collection, or
   article writing.
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NR 35
TC 0
Z9 0
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
EI 2047-9980
J9 J AM HEART ASSOC
JI J. Am. Heart Assoc.
PD OCT 15
PY 2024
VL 13
IS 20
AR e035052
DI 10.1161/JAHA.124.035052
PG 10
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA I8K7D
UT WOS:001332695300019
PM 39392020
DA 2025-06-11
ER

PT J
AU Malik, AA
   Williams, CA
   Weston, KL
   Barker, AR
AF Malik, Adam A.
   Williams, Craig A.
   Weston, Kathryn L.
   Barker, Alan R.
TI Perceptual and Cardiorespiratory Responses to High-Intensity Interval
   Exercise in Adolescents: Does Work Intensity Matter?
SO JOURNAL OF SPORTS SCIENCE AND MEDICINE
LA English
DT Article
DE Affective valence; exercise motivation; interval exercise; work
   intensity; youth
ID PHYSICAL-ACTIVITY INTENSITY; CARDIOMETABOLIC RISK; ENJOYMENT RESPONSES;
   PERCEIVED EXERTION; AEROBIC EXERCISE; CHILDREN; HEALTH; OVERWEIGHT;
   PREDICTION; FITNESS
AB High-intensity interval exercise (HIIE) may not elicit prominent unpleasant feelings even with elevated perceived exertion and physiological stress in adolescents. However, the influence of different HIIE work intensities on the affective experience and cardiorespiratory responses is unknown. This study examined the acute affective, enjoyment, perceived exertion and cardiorespiratory responses to HIIE with different work intensities in adolescents. Participants (n = 16; 8 boys; age 12.0 +/- 0.3 years) performed, on separate days, HIIE conditions consisting of 8 x 1-minute work-intervals at 70%, 85%, or 100% peak power separated by 75 seconds recovery at 20 W. Affect, enjoyment and rating of perceived exertion (RPE) were recorded before, during, and after HIIE. Heart rate (HR) and oxygen uptake were collected during HIIE. Affect declined in all conditions (p < 0.01) but 100%FilIE elicited significantly lower affect than 70% HIIE and 85% HIIE at work-interval 8 (all p < 0.02, ES > 1.74; 70% HIIE = 2.5 +/- 0.8; 85% HIIE = 1.1 +/- 1.5; 100% HIIE = -1.5 +/- 1.4 on feeling scale). Similar enjoyment was evident during and after all conditions (all p > 0.44). RPE was significantly higher during 100% HIIE than 70% HIIE and 85% HIIE across all work-intervals (all p < 0.01, ES > 1.56). The majority of the participants attained >= 90 HRmax during 85% HIIE (87%) and 100% HIIE (100%), but not during 70% HIIE (6%). Affect responses during HIIE are dependent on the intensity of the work-interval and are not entirely negative (unpleasant feelings). Despite similar enjoyment, positive affect experienced during 70% HIIE and 85%HIIE could serve as a strategy to encourage exercise adoption and adherence in adolescents, but only 85% HIIE elicits sufficient HR stimulus to facilitate potential health benefits.
C1 [Malik, Adam A.; Williams, Craig A.; Barker, Alan R.] Univ Exeter, Coll Life & Environm Sci, Childrens Hlth & Exercise Res Ctr, Sport & Hlth Sci, St Lukes Campus, Exeter EX1 2LU, Devon, England.
   [Malik, Adam A.] Univ Sains Malaysia, Sch Hlth Sci, Exercise & Sports Sci Programme, George Town, Malaysia.
   [Weston, Kathryn L.] Teesside Univ, Sch Hlth & Social Care, Middlesbrough, Cleveland, England.
C3 University of Exeter; Universiti Sains Malaysia; University of Teesside
RP Barker, AR (corresponding author), Univ Exeter, Coll Life & Environm Sci, Childrens Hlth & Exercise Res Ctr, Sport & Hlth Sci, St Lukes Campus, Exeter EX1 2LU, Devon, England.
EM aa643@exeter.ac.uk; C.A.Williams@exeter.ac.uk; k.weston@tees.ac.uk;
   A.R.Barker@exeter.ac.uk
RI Weston, Kathryn/AAB-3155-2020; Malik, Adam/Q-8879-2019; Barker,
   Alan/AAF-7777-2020; Williams, Craig/AAQ-8954-2020
OI Williams, Craig/0000-0002-1740-6248; Abdul Malik,
   Adam/0000-0001-8982-5735; Barker, Alan/0000-0001-8610-5417; Weston,
   Kathryn/0000-0001-5918-6389
FU Government of Malaysia
FX The reported experiments comply with the current laws of the country in
   which they were performed. The authors have no conflicts of interests to
   declare. The authors thank the staff and participants at Cranbrook
   Education School (Devon, UK) for their participation in this project.
   The authors also thank Mr Sam Bailey and Dr Luke Connolly for their help
   with the technical support of the equipment. Finally, the authors thank
   Miss Lucy Gowing and Mr Max Weston for their help with data collection.
   Adam Abdul Malik is financially supported by the Government of Malaysia
   for the funding under the academic staff training scheme
   (USM/PPSP(Pent)/L2/bJld.XV).
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NR 45
TC 38
Z9 41
U1 1
U2 15
PU JOURNAL SPORTS SCIENCE & MEDICINE
PI BURSA
PA MEDICAL FACULTY ULUDAG UNIV, DEPT SPORTS MEDICINE, BURSA, 16059, TURKEY
SN 1303-2968
J9 J SPORT SCI MED
JI J. Sport. Sci. Med.
PD MAR
PY 2019
VL 18
IS 1
BP 1
EP 12
PG 12
WC Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Sport Sciences
GA HK9GU
UT WOS:000458299400001
PM 30787646
DA 2025-06-11
ER

PT J
AU Szczerbinska, K
   Topinková, E
   Brzyski, P
   van der Roest, HG
   Richter, T
   Finne-Soveri, H
   Denkinger, MD
   Gindin, J
   Onder, G
   Bernabei, R
AF Szczerbinska, Katarzyna
   Topinkova, Eva
   Brzyski, Piotr
   van der Roest, Henriette G.
   Richter, Tomas
   Finne-Soveri, Harriet
   Denkinger, Michael D.
   Gindin, Jacob
   Onder, Graziano
   Bernabei, Roberto
TI The Characteristics of Diabetic Residents in European Nursing Homes:
   Results from the SHELTER Study
SO JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
LA English
DT Article
DE Diabetes mellitus; nursing home; older adults
ID MINIMUM DATA SET; METABOLIC SYNDROME; COGNITIVE DECLINE; CARE;
   PREVALENCE; RISK; MELLITUS; HEALTH; LIFE; DEPRESSION
AB Objectives: The objectives of this study were to describe the prevalence of diabetes mellitus (DM) in European nursing homes (NHs), and the health and functional characteristics of diabetic residents (DMR) aged 60 years and older.
   Design: Between 2009 and 2011, the Services and Health for Elderly in Long TERm care (SHELTER) project, a 12-month prospective cohort study, was conducted to assess NH residents across different health care systems in 7 European countries and Israel.
   Methods: The study included 59 NHs in 8 countries with a total of 4037 residents living in or admitted to a NH during the 3-month enrollment period. The multidimensional InterRAI instrument for Long-Term Care Facilities (InterRAI-LTCF) was used to assess health and functional status among residents. Descriptive statistics and linear, ordinal, and logistic regression were used to perform the analyses.
   Results: We found a 21.8% prevalence of DM among NH residents. Residents with DM (DMRs) were significantly younger compared with non-DMRs (82.3, SD +/- 7.7; 84.6, SD +/- 8.4; P < .001). DMRs were more frequently overweight or obese, and presented more often with ischemic heart disease, congestive heart failure, hypertension, and stroke than residents without DM. DMRs also took more drugs, had pressure ulcers (PU) or other wounds more often, and more frequently had urinary incontinence (UI); they also reported worse self-perceived health. DM independently of other factors increased risk of PU occurrence (odds ratio 1.38; 95% confidence interval [CI] 1.02-1.86; P = .036) and decreased probability of higher pain scores (B = -0.28; 95% CI -0.41 to -0.14; P < .001). DM was not associated with ADL dependency, cognitive impairment, and depression in NH residents.
   Conclusion: Prevalence of DM in European NH residents is comparable to US national NH surveys, and to UK and German NH data based on glucose-level testing. DMRs compared with non-DMRs have more comorbid conditions, and a particularly higher incidence of cardiovascular diseases and obesity, PU, and severe UI. DMRs should be regarded as a specific group of residents who require an interdisciplinary approach in medical and nursing care. (C) 2015 AMDA - The Society for Post-Acute and Long-Term Care Medicine.
C1 [Szczerbinska, Katarzyna; Brzyski, Piotr] Jagiellonian Univ, Coll Med, Fac Med, Dept Sociol Med,Epidemiol & Prevent Med Chair, PL-31034 Krakow, Poland.
   [Topinkova, Eva; Richter, Tomas] Charles Univ Prague, Fac Med 1, Dept Geriatr, Prague, Czech Republic.
   [van der Roest, Henriette G.] Vrije Univ Amsterdam Med Ctr, EMGO Inst Hlth & Care Res, Dept Gen Practice & Elderly Care, Amsterdam, Netherlands.
   [Finne-Soveri, Harriet] Natl Inst Hlth & Welf, Unit Ageing & Serv, Helsinki, Finland.
   [Denkinger, Michael D.] Univ Ulm, Geriatr Ctr Ulm Alb Donau, Agaples Bethesda Clin, D-89069 Ulm, Germany.
   [Gindin, Jacob] Univ Haifa, Res Author, Ctr Stand Hlth & Disabil, IL-31999 Haifa, Israel.
   [Onder, Graziano; Bernabei, Roberto] Univ Cattolica Sacro Cuore, Ctr Med Invecchiamento, Rome, Italy.
C3 Jagiellonian University; Collegium Medicum Jagiellonian University;
   Charles University Prague; General University Hospital Prague; Vrije
   Universiteit Amsterdam; VU UNIVERSITY MEDICAL CENTER; Finland National
   Institute for Health & Welfare; Ulm University; University of Haifa;
   Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli
RP Szczerbinska, K (corresponding author), Jagiellonian Univ, Coll Med, Ul Kopernika 7a, PL-31034 Krakow, Poland.
EM katarzyna.szczerbinska@uj.edu.pl
RI Bernabei, Roberto/AAB-2704-2019; van der Roest, Henriëtte/AAB-3641-2019;
   Szczerbinska, Katarzyna/MZQ-4227-2025; Topinkova, Eva/A-5076-2019;
   Denkinger, Michael/E-1814-2013; Richter, Tomas/E-3287-2017
OI Topinkova, Eva/0000-0002-6786-4116; Szczerbinska,
   Katarzyna/0000-0002-0004-3858; Denkinger, Michael/0000-0002-8097-060X;
   van der Roest, Henriette/0000-0001-9898-923X; BERNABEI,
   Roberto/0000-0002-9197-004X; Richter, Tomas/0000-0001-6038-9554
FU European Union's Seventh Framework Programme for Research, European
   Commission [223115]; FP7 European Commission "The MID-FRAIL Study"
   [278803]
FX The SHELTER study was funded by the European Union's Seventh Framework
   Programme for Research, European Commission Grant 223115. The work of ET
   and TR was partly supported by FP7 European Commission Grant 278803 "The
   MID-FRAIL Study."
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NR 45
TC 16
Z9 16
U1 1
U2 16
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1525-8610
EI 1538-9375
J9 J AM MED DIR ASSOC
JI J. Am. Med. Dir. Assoc.
PD APR 1
PY 2015
VL 16
IS 4
BP 334
EP 340
DI 10.1016/j.jamda.2014.11.009
PG 7
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA CE6KT
UT WOS:000351946000014
PM 25533147
DA 2025-06-11
ER

PT J
AU Trigo, JP
   Palmnäs-Bédard, M
   Juanola, MVL
   Undeland, I
AF Trigo, Joao P.
   Palmnaes-Bedard, Marie
   Juanola, Mar Vall-Llosera
   Undeland, Ingrid
TI Effects of whole seaweed consumption on humans: current evidence from
   randomized-controlled intervention trials, knowledge gaps, and
   limitations
SO FRONTIERS IN NUTRITION
LA English
DT Review
DE macroalgae; seaweed consumption; novel food; risk-of-bias; disease
   prevention; health promotion
ID UNDARIA-PINNATIFIDA WAKAME; DOUBLE-BLIND; CARDIOVASCULAR-DISEASE;
   POSTPRANDIAL GLUCOSE; THYROID-FUNCTION; ENRICHED BREAD; BLOOD-PRESSURE;
   HEALTHY; LEVEL; NUTRACEUTICALS
AB Seaweed is often recognized for its potential health benefits, attributed to its abundance of dietary fibers, protein, and polyphenols. While human observational studies have shown promise, the collective evidence from human intervention trials remains limited. This narrative review aims to comprehensively analyze the effects of seaweed intake on humans, while critically assessing the methodology, including Cochrane risk-of-bias assessment. A search was conducted in online databases, including PubMed, Scopus, and Google Scholar, covering the period from 2000 to May 2023. The focus was on randomized controlled clinical trials (RCTs) evaluating the impact of whole seaweed, either consumed as capsules, integrated into food products or as part of meals. Various health outcomes were examined, including appetite, anthropometric measures, cardiometabolic risk factors, thyroid function, markers of oxidative stress, and blood mineral concentrations. Out of the 25 RCTs reviewed, the findings revealed limited yet encouraging evidence for effects of seaweed on blood glucose metabolism, blood pressure, anthropometric measures, and, to a lesser extent, blood lipids. Notably, these favorable effects were predominantly observed in populations with type-2 diabetes and hypertension. Despite most trials selecting a seaweed dose aligning with estimated consumption levels in Japan, considerable variability was observed in the pretreatment and delivery methods of seaweed across studies. Moreover, most studies exhibited a moderate-to-high risk of bias, posing challenges in drawing definitive conclusions. Overall, this review highlights the necessity for well-designed RCTs with transparent reporting of methods and results. Furthermore, there is a need for RCTs to explore seaweed species cultivated outside of Asia, with a specific emphasis on green and red species. Such studies will provide robust evidence-based support for the growing utilization of seaweed as a dietary component in regions with negligible seaweed consumption, e.g., Europe.
C1 [Trigo, Joao P.; Palmnaes-Bedard, Marie; Juanola, Mar Vall-Llosera; Undeland, Ingrid] Chalmers Univ Technol, Dept Life Sci, Div Food & Nutr Sci, Gothenburg, Sweden.
C3 Chalmers University of Technology
RP Trigo, JP (corresponding author), Chalmers Univ Technol, Dept Life Sci, Div Food & Nutr Sci, Gothenburg, Sweden.
EM trigo@chalmers.se
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NR 85
TC 9
Z9 11
U1 3
U2 10
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD JUL 20
PY 2023
VL 10
AR 1226168
DI 10.3389/fnut.2023.1226168
PG 17
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA N9BA9
UT WOS:001039869400001
PM 37545570
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Lin, E
   Kuo, PH
   Liu, YL
   Yu, YWY
   Yang, AC
   Tsai, SJ
AF Lin, Eugene
   Kuo, Po-Hsiu
   Liu, Yu-Li
   Yu, Younger W. -Y.
   Yang, Albert C.
   Tsai, Shih-Jen
TI A Deep Learning Approach for Predicting Antidepressant Response in Major
   Depression Using Clinical and Genetic Biomarkers
SO FRONTIERS IN PSYCHIATRY
LA English
DT Article
DE antidepressant; deep learning; genome-wide association studies; major
   depressive disorder; multilayer feedforward neural networks;
   personalized medicine; single nucleotide polymorphisms
ID GENOME-WIDE ASSOCIATION; BIPOLAR DISORDER; PERSONALIZED MEDICINE;
   TAIWANESE POPULATION; ENVIRONMENT INTERACTIONS; METABOLIC SYNDROME; MOOD
   DISORDERS; DRUG EFFICACY; CLOCK GENES; HEALTH-CARE
AB In the wake of recent advances in scientific research, personalized medicine using deep learning techniques represents a new paradigm. In this work, our goal was to establish deep learning models which distinguish responders from non-responders, and also to predict possible antidepressant treatment outcomes in major depressive disorder (MDD). To uncover relationships between the responsiveness of antidepressant treatment and biomarkers, we developed a deep learning prediction approach resulting from the analysis of genetic and clinical factors such as single nucleotide polymorphisms (SNPs), age, sex, baseline Hamilton Rating Scale for Depression score, depressive episodes, marital status, and suicide attempt status of MDD patients. The cohort consisted of 455 patients who were treated with selective serotonin reuptake inhibitors (treatment-response rate = 61.0%; remission rate = 33.0%). By using the SNP dataset that was original to a genome-wide association study, we selected 10 SNPs (including ABCA13 rs4917029, BNIP3 rs9419139, CACNA1E rs704329, EXOC4 rs6978272, GRIN2B rs7954376, LHFPL3 rs4352778, NELL1 rs2139423, NUAK1 rs2956406, PREX1 rs4810894, and SLIT3 rs139863958) which were associated with antidepressant treatment response. Furthermore, we pinpointed 10 SNPs (including ARNTL rs11022778, CAMK1D rs2724812, GABRB3 rs12904459, GRM8 rs35864549, NAALADL2 rs9878985, NCALD rs483986, PLA2G4A rs12046378, PROK2 rs73103153, RBFOX1 rs17134927, and ZNF536 rs77554113) in relation to remission. Then, we employed multilayer feedforward neural networks (MFNNs) containing 1-3 hidden layers and compared MFNN models with logistic regression models. Our analysis results revealed that the MFNN model with 2 hidden layers (area under the receiver operating characteristic curve (AUC) = 0.8228 +/- 0.0571; sensitivity = 0.7546 +/- 0.0619; specificity = 0.6922 +/- 0.0765) performed maximally among predictive models to infer the complex relationship between antidepressant treatment response and biomarkers. In addition, the MFNN model with 3 hidden layers (AUC = 0.8060 +/- 0.0722; sensitivity = 0.7732 +/- 0.0583; specificity = 0.6623 +/- 0.0853) achieved best among predictive models to predict remission. Our study indicates that the deep MFNN framework may provide a suitable method to establish a tool for distinguishing treatment responders from non-responders prior to antidepressant therapy.
C1 [Lin, Eugene] Univ Washington, Dept Elect Engn, Seattle, WA 98195 USA.
   [Lin, Eugene] China Med Univ, Grad Inst Biomed Sci, Taichung, Taiwan.
   [Kuo, Po-Hsiu] Natl Taiwan Univ, Inst Epidemiol & Prevent Med, Dept Publ Hlth, Taipei, Taiwan.
   [Liu, Yu-Li] Natl Hlth Res Inst, Ctr Neurophys Res, Miaoli, Taiwan.
   [Yu, Younger W. -Y.] Yus Psychiatr Clin, Kaohsiung, Taiwan.
   [Yang, Albert C.; Tsai, Shih-Jen] Taipei Vet Gen Hosp, Dept Psychiat, Taipei, Taiwan.
   [Yang, Albert C.; Tsai, Shih-Jen] Natl Yang Ming Univ, Div Psychiat, Taipei, Taiwan.
   [Yang, Albert C.] Harvard Med Sch, Beth Israel Med Ctr, Div Interdisciplinary Med & Biotechnol, Boston, MA USA.
   [Yang, Albert C.; Tsai, Shih-Jen] Natl Yang Ming Univ, Inst Brain Sci, Taipei, Taiwan.
C3 University of Washington; University of Washington Seattle; China
   Medical University Taiwan; National Taiwan University; National Health
   Research Institutes - Taiwan; Taipei Veterans General Hospital; National
   Yang Ming Chiao Tung University; Harvard University; Harvard Medical
   School; Harvard University Medical Affiliates; Beth Israel Deaconess
   Medical Center; National Yang Ming Chiao Tung University
RP Lin, E (corresponding author), Univ Washington, Dept Elect Engn, Seattle, WA 98195 USA.; Lin, E (corresponding author), China Med Univ, Grad Inst Biomed Sci, Taichung, Taiwan.; Tsai, SJ (corresponding author), Taipei Vet Gen Hosp, Dept Psychiat, Taipei, Taiwan.; Tsai, SJ (corresponding author), Natl Yang Ming Univ, Div Psychiat, Taipei, Taiwan.; Tsai, SJ (corresponding author), Natl Yang Ming Univ, Inst Brain Sci, Taipei, Taiwan.
EM lines@uw.edu; tsai610913@gmail.com
RI wang, zhenhui/JMQ-0550-2023; Tsai, Shih-Jen/AAK-7944-2020; Kuo,
   Po-Hsiu/H-9882-2013; Yang, Albert/JSL-0102-2023
OI Kuo, Po-Hsiu/0000-0003-0365-3587; Yang, Albert
   Chih-Chieh/0000-0003-2794-9649
FU Taipei Veterans General Hospital, Taiwan [V105D17-002-MY2-2]; Ministry
   of Science and Technology, Taiwan [MOST 107-2634-F-075-002, MOST
   107-2634-F-002-019]
FX This work was supported by Taipei Veterans General Hospital, Taiwan
   (Grant V105D17-002-MY2-2) and by the Ministry of Science and Technology,
   Taiwan (Grant MOST 107-2634-F-075-002; MOST 107-2634-F-002-019).
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NR 57
TC 117
Z9 128
U1 1
U2 27
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-0640
J9 FRONT PSYCHIATRY
JI Front. Psychiatry
PD JUL 6
PY 2018
VL 9
AR 290
DI 10.3389/fpsyt.2018.00290
PG 10
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA GL9VV
UT WOS:000437691100001
PM 30034349
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Chiavaroli, V
   Marcovecchio, ML
   de Giorgis, T
   Diesse, L
   Chiarelli, F
   Mohn, A
AF Chiavaroli, Valentina
   Marcovecchio, Maria Loredana
   de Giorgis, Tommaso
   Diesse, Laura
   Chiarelli, Francesco
   Mohn, Angelika
TI Progression of Cardio-Metabolic Risk Factors in Subjects Born Small and
   Large for Gestational Age
SO PLOS ONE
LA English
DT Article
ID INSULIN-RESISTANCE; CARDIOMETABOLIC RISK; CARDIOVASCULAR RISK;
   PHYSICAL-ACTIVITY; OXIDATIVE STRESS; CHILDHOOD; CHILDREN; GROWTH; BIRTH;
   SIZE
AB Background: Subjects born small (SGA) and large (LGA) for gestational age have an increased risk of cardio-metabolic alterations already during prepuberty. Nevertheless, the progression of their cardio-metabolic profile from childhood to adolescence has not been fully explored. Our aim was to assess potential changes in the cardio-metabolic profile from childhood to adolescence in subjects born SGA and LGA compared to those born appropriate (AGA) for gestational age.
   Methods: This longitudinal study included 35 AGA, 24 SGA and 31 LGA subjects evaluated during childhood (mean age (+/- SD) 8.4 +/- 1.4 yr) and then re-assessed during adolescence (mean age 13.3 +/- 1.8 yr). BMI, blood pressure, insulin resistance (fasting insulin, HOMA-IR) and lipids were assessed. A cardio-metabolic risk z-score was applied and this consisted in calculating the sum of sex-specific z-scores for BMI, blood pressure, HOMA-IR, triglycerides and triglycerides: high-density lipoprotein cholesterol ratio.
   Results: Fasting insulin and HOMA-IR were higher in SGA and LGA than AGA subjects both during childhood (all P<0.01) and adolescence (all P<0.01). Similarly, the clustered cardio-metabolic risk score was higher in SGA and LGA than AGA children (both P<0.05), and these differences among groups increased during adolescence (both P<0.05). Of note, a progression of the clustered cardio-metabolic risk score was observed from childhood to adolescence within SGA and within LGA subjects (both P<0.05).
   Conclusions: SGA and LGA subjects showed an adverse cardio-metabolic profile during childhood when compared to AGA peers, with a worsening of this profile during adolescence. These findings indicate an overtime progression of insulin resistance and overall estimated cardiovascular risk from childhood to adolescence in SGA and LGA populations.
C1 [Chiavaroli, Valentina; Marcovecchio, Maria Loredana; de Giorgis, Tommaso; Diesse, Laura; Chiarelli, Francesco; Mohn, Angelika] Univ G dAnnunzio, Dept Paediat, Chieti, Italy.
   [Chiavaroli, Valentina; Marcovecchio, Maria Loredana; de Giorgis, Tommaso; Chiarelli, Francesco; Mohn, Angelika] Univ G dAnnunzio, G DAnnunzio Univ Fdn, Ctr Excellence Aging, Chieti, Italy.
C3 G d'Annunzio University of Chieti-Pescara; G d'Annunzio University of
   Chieti-Pescara
RP Chiavaroli, V (corresponding author), Univ G dAnnunzio, Dept Paediat, Chieti, Italy.
EM valentinachiavaroli@hotmail.it
RI Chiavaroli, Valentina/ABB-1911-2020
OI Maria Loredana, Marcovecchio/0000-0002-4415-316X; Chiavaroli,
   Valentina/0000-0003-0555-2173
CR Andersen LB, 2008, INT J PEDIATR OBES, V3, P58, DOI 10.1080/17477160801896366
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NR 38
TC 68
Z9 70
U1 0
U2 3
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD AUG 12
PY 2014
VL 9
IS 8
AR e104278
DI 10.1371/journal.pone.0104278
PG 7
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA AO3LJ
UT WOS:000341230400040
PM 25117750
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Gonzalez-Rivas, JP
   Mechanick, J
   Infante-Garcia, MM
   Medina-Inojosa, JR
   Pavlovska, I
   Hlinomaz, O
   Zak, P
   Kunzova, S
   Nieto-Martinez, R
   Skladaná, M
   Broz, J
   Hernandez, JP
   Lopez-Jimenez, F
   Stokin, GB
AF Gonzalez-Rivas, Juan P.
   Mechanick, Jeffrey, I
   Infante-Garcia, Maria M.
   Medina-Inojosa, Jose R.
   Pavlovska, Iuliia
   Hlinomaz, Ota
   Zak, Petr
   Kunzova, Sarka
   Nieto-Martinez, Ramfis
   Skladana, Maria
   Broz, Jan
   Hernandez, Jose Pantaleon
   Lopez-Jimenez, Francisco
   Stokin, Gorazd B.
TI The Prevalence of Dysglycemia-Based Chronic Disease in a European
   Population - a New Paradigm to Address Diabetes Burden: A Kardiovize
   Study
SO ENDOCRINE PRACTICE
LA English
DT Article
DE cardiovascular disease; diabetes; epidemiology; type 2 diabetes mellitus
ID CLINICAL ENDOCRINOLOGISTS; AMERICAN ASSOCIATION; SOCIOECONOMIC-STATUS;
   ADIPOSITY; STRESS; HEALTH
AB Objective: To determine the prevalence rate and associated risk factors for each stage of the Dysglycemia-Based Chronic Disease (DBCD) model, which 4 distinct stages and prompts early prevention to avert Diabetes and cardiometabolic complications.
   Methods: Subjects between 25 and 64 years old from a random population-based sample were evaluated in Czechia from 2013 to 2014 using a cross-sectional design. DBCD stages were: stage 1 "insulin resistance" (inferred risk from abdominal obesity or a family history of diabetes); stage 2 "prediabetes"(fasting glucose between 5.6 and 6.9 mmol/L); stage 3 "type 2 diabetes (T2D)" (self-report of T2D or fasting glucose >= 7 mmol/L); and stage 4 "vascular complications" (T2D with cardiovascular disease).
   Results: A total of 2147 subjects were included (57.8% women) with a median age of 48 years. The prevalence of each DBCD stage were as follows: 54.2% (stage 1); 10.3% (stage 2), 3.7% (stage 3); and 1.2% (stage 4). Stages 2 to 4 were more frequent in men and stage 1 in women (P < .001). Using binary logistic regression analysis adjusting by age/sex, all DBCD stages were strongly associated with abnormal adiposity, hypertension, dyslipidemia, and smoking status. Subjects with lower educational levels and lower income were more likely to present DBCD.
   Conclusion: Using the new DBCD framework and available metrics, 69.4% of the population had DBCD, identifying far more people at risk than a simple prevalence rate for T2D (9.2% in Czechia, 2013-2014). All stages were associated with traditional cardiometabolic risk factors, implicating common pathophysiologic mechanisms and a potential for early preventive care. The social determinants of health were related with all DBCD stages in alarming proportions and will need to be further studied. (C) 2020 AACE. Published by Elsevier Inc.
C1 [Gonzalez-Rivas, Juan P.; Pavlovska, Iuliia; Hlinomaz, Ota; Kunzova, Sarka; Skladana, Maria; Hernandez, Jose Pantaleon; Stokin, Gorazd B.] St Annes Univ Hosp FNUSA, Dept Int Clin Res Ctr ICRC, Brno, Czech Republic.
   [Gonzalez-Rivas, Juan P.; Nieto-Martinez, Ramfis] Harvard Univ, TH Chan Sch Publ Hlth, Dept Global Hlth & Populat, Boston, MA 02115 USA.
   [Mechanick, Jeffrey, I] Icahn Sch Med Mt Sinai, Marie Josee & Henry R Kravis Ctr Cardiovasc Hlth, New York, NY 10029 USA.
   [Mechanick, Jeffrey, I] Icahn Sch Med Mt Sinai, Div Endocrinol Diabet & Bone, New York, NY 10029 USA.
   [Infante-Garcia, Maria M.] Fdn Clin Publ Hlth & Epidemiol Res Venezuela FISP, Caracas, Venezuela.
   [Medina-Inojosa, Jose R.; Lopez-Jimenez, Francisco] Mayo Clin, Prevent Cardiol, Rochester, MN USA.
   [Pavlovska, Iuliia] Masaryk Univ, Fac Med, Dept Publ Hlth, Brno, Czech Republic.
   [Zak, Petr] St Annes Univ Hosp FNUSA, Diabetol Dept, Brno, Czech Republic.
   [Nieto-Martinez, Ramfis] LifeDoc Diabet & Obes Clin, Memphis, TN USA.
   [Broz, Jan] Charles Univ Prague, Dept Internal Med, Fac Med 2, Prague, Czech Republic.
C3 St. Anne's University Hospital Brno (FNUSA); Harvard University; Harvard
   T.H. Chan School of Public Health; Icahn School of Medicine at Mount
   Sinai; Icahn School of Medicine at Mount Sinai; Mayo Clinic; Masaryk
   University Brno; St. Anne's University Hospital Brno (FNUSA); Motol
   University Hospital; Charles University Prague
RP Gonzalez-Rivas, JP (corresponding author), St Annes Univ Hosp Brno, Int Clin Res Ctr, Pekarska 53, Brno 65691, Czech Republic.
EM juan.gonzalez@fnusa.cz
RI Pavlovska, Iuliia/ISS-4979-2023; Medina-Inojosa, Jose/Z-5609-2019;
   Stokin, Gorazd/D-9480-2015; Gonzalez Rivas, Juan Pablo/HZK-6756-2023;
   Hlinomaz, Ota/I-3906-2016; Martinez, Andrea/KHX-0081-2024; Žák,
   Petr/AGQ-2785-2022; Broz, Jan/E-6919-2018
OI Medina-Inojosa, Jose/0000-0001-8705-0462; Pavlovska,
   Iuliia/0000-0003-3730-3817; Hrabcakova Skladana,
   Maria/0000-0001-5008-3279; Nieto-Martinez, Ramfis/0000-0002-0575-7534;
   Broz, Jan/0000-0003-2465-7333
FU European Regional Development Fund e Project FNUSAICRC
   [CZ.1.05/1.1.00/02.0123]; National Program of Sustainability II (MEYS
   CR) [LQ1605]; project ICRC-ERA-Human Bridge - European Union [316345];
   Ministry of Health of the Czech Republic [NT13434-4/2012]
FX We thank all participants who participated in this study. The Kardiovize
   study was supported by the European Regional Development Fund e Project
   FNUSAICRC (no. CZ.1.05/1.1.00/02.0123), by project no. LQ1605 from the
   National Program of Sustainability II (MEYS CR), by project
   ICRC-ERA-Human Bridge (no. 316345) funded by the 7th Framework Program
   of the European Union, and partly by a grant by the Ministry of Health
   of the Czech Republic (NT13434-4/2012).
CR [Anonymous], CZECH REP COUNTR PRO
   Baum A, 1999, ANN NY ACAD SCI, V896, P131, DOI 10.1111/j.1749-6632.1999.tb08111.x
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   Centers for Disease Control and Prevention, National diabetes Statistics Report
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NR 24
TC 7
Z9 7
U1 1
U2 7
PU ELSEVIER INC
PI SAN DIEGO
PA 525 B STREET, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 1530-891X
EI 1934-2403
J9 ENDOCR PRACT
JI Endocr. Pract.
PD MAY
PY 2021
VL 27
IS 5
BP 455
EP 462
DI 10.1016/j.eprac.2020.10.003
EA APR 2021
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA RT7TJ
UT WOS:000644659800012
PM 33685667
OA hybrid
DA 2025-06-11
ER

PT J
AU Eriksson, JG
   Guzzardi, MA
   Iozzo, P
   Kajantie, E
   Kautiainen, H
   Salonen, MK
AF Eriksson, Johan G.
   Guzzardi, Maria-Angela
   Iozzo, Patricia
   Kajantie, Eero
   Kautiainen, Hannu
   Salonen, Minna K.
TI Higher serum phenylalanine concentration is associated with more rapid
   telomere shortening in men
SO AMERICAN JOURNAL OF CLINICAL NUTRITION
LA English
DT Article
DE aging; amino acids; telomeres; phenylalanine; telomere shortening;
   longitudinal study
ID INSULIN-RESISTANCE; OXIDATIVE STRESS; RISK-FACTORS; LENGTH; BIRTH;
   DISEASE; PHENYLKETONURIA; PREVENTION; CHILDHOOD; OBESITY
AB Background: Telomere length and telomere shortening are associated with age-related health outcomes. Only a few studies have been able to longitudinally report on factors that are associated with changes in telomere length in an aging population.
   Objective: We studied the longitudinal relation between telomere length, the change in telomere length, and circulating amino acids.
   Design: A total of 812 subjects from the Helsinki Birth Cohort Study (born from 1934 to 1944), who underwent 3 clinical visits during a 10-y interval that included measurements of cardiometabolic risk factors, were included in the study. Leukocyte telomere length (LTL) was measured with the use of quantitative real-time polymerase chain reaction. Circulating branched-chain and aromatic amino acids (alanine, glycine, histidine, phenylalanine, leucine, isoleucine, valine, and tyrosine) were assessed with the use of high-throughput nuclear magnetic resonance spectroscopy.
   Results: The relative +/- SD LTL at a mean age of 71 y was 0.79 +/- 0.27 in men and 0.89 +/- 0.35 in women (P < 0.001). Of the studied amino acids, the strongest inverse association was observed between the phenylalanine concentration that was measured 5 y earlier and the LTL. This finding was significant in men (P = 0.021) and remained significant after adjustment for multiple comparisons, but it was not significant in women (P = 0.39). Longitudinally, the change in LTL over 10 y was inversely associated with the phenylalanine concentration in men (P = 0.007) but not in women (P = 0.58) after adjustment for baseline LTL, age, smoking, and percentage of body fat.
   Conclusions: The serum phenylalanine concentration is associated with telomere length and, therefore, potentially with the aging process. Because the associations reported are observational, no conclusions can be made regarding causality. Our findings support the hypothesis that cellular pathways that regulate aging are sex specific.
C1 [Eriksson, Johan G.; Kajantie, Eero; Salonen, Minna K.] Natl Inst Hlth & Welf, Dept Chron Dis Prevent, Helsinki, Finland.
   [Eriksson, Johan G.; Kautiainen, Hannu] Univ Helsinki, Dept Gen Practice & Primary Hlth Care, Helsinki, Finland.
   [Eriksson, Johan G.; Kautiainen, Hannu] Helsinki Univ Hosp, Helsinki, Finland.
   [Eriksson, Johan G.; Kautiainen, Hannu] Folkhalsan Res Ctr, Helsinki, Finland.
   [Guzzardi, Maria-Angela; Iozzo, Patricia] CNR, Inst Clin Physiol, Pisa, Italy.
   [Kajantie, Eero] Univ Helsinki, Childrens Hosp, Helsinki, Finland.
   [Kajantie, Eero] Univ Helsinki, Helsinki, Finland.
   [Kajantie, Eero] Oulu Univ Hosp, MRC Oulu, Dept Obstet & Gynecol, Oulu, Finland.
   [Kajantie, Eero] Univ Oulu, Oulu, Finland.
   [Kautiainen, Hannu] Univ Eastern Finland, Kuopio, Finland.
C3 Finland National Institute for Health & Welfare; University of Helsinki;
   University of Helsinki; Helsinki University Central Hospital; Folkhalsan
   Research Center; Consiglio Nazionale delle Ricerche (CNR); Istituto di
   Fisiologia Clinica (IFC-CNR); University of Helsinki; University of
   Helsinki; University of Oulu; University of Oulu; University of Eastern
   Finland
RP Eriksson, JG (corresponding author), Natl Inst Hlth & Welf, Dept Chron Dis Prevent, Helsinki, Finland.; Eriksson, JG (corresponding author), Univ Helsinki, Dept Gen Practice & Primary Hlth Care, Helsinki, Finland.; Eriksson, JG (corresponding author), Helsinki Univ Hosp, Helsinki, Finland.; Eriksson, JG (corresponding author), Folkhalsan Res Ctr, Helsinki, Finland.
EM johan.eriksson@helsinki.fi
RI Iozzo, P/O-2893-2015; Gibbs, J. Raphael/A-3984-2010; GUZZARDI,
   MARIAANGELA/K-1389-2016
OI GUZZARDI, MARIAANGELA/0000-0001-9574-5088
FU Finska Lakaresallskapet; Finnish Special Governmental Subsidy for Health
   Sciences; Academy of Finland; Samfundet Folkhalsan; Liv och Halsa; Signe
   and Ane Gyllenberg Foundation; EU FP7 [Developmental Origins of Healthy
   Aging (DORIAN)] [278603]; EU H2020-PHC-DynaHealth [633595]
FX Supported by grants from Finska Lakaresallskapet, the Finnish Special
   Governmental Subsidy for Health Sciences, Academy of Finland, Samfundet
   Folkhalsan, Liv och Halsa, the Signe and Ane Gyllenberg Foundation, EU
   FP7 [Developmental Origins of Healthy Aging (DORIAN)] project number
   278603, and EU H2020-PHC-2014-DynaHealth grant 633595 (all for the
   Helsinki Birth Cohort Study).
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NR 38
TC 9
Z9 9
U1 1
U2 9
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0002-9165
EI 1938-3207
J9 AM J CLIN NUTR
JI Am. J. Clin. Nutr.
PD JAN
PY 2017
VL 105
IS 1
BP 144
EP 150
DI 10.3945/ajcn.116.130468
PG 7
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA EG8YU
UT WOS:000391344400018
PM 27881392
OA Bronze
DA 2025-06-11
ER

PT J
AU Hjorth, MF
   Sjödin, A
   Dalskov, SM
   Damsgaard, CT
   Michaelsen, KF
   Biltoft-Jensen, A
   Andersen, R
   Ritz, C
   Chaput, JP
   Astrup, A
AF Hjorth, Mads F.
   Sjodin, Anders
   Dalskov, Stine-Mathilde
   Damsgaard, Camilla Trab
   Michaelsen, Kim F.
   Biltoft-Jensen, Anja
   Andersen, Rikke
   Ritz, Christian
   Chaput, Jean-Philippe
   Astrup, Arne
TI Sleep duration modifies effects of free ad libitum school meals on
   adiposity and blood pressure
SO APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
LA English
DT Article
DE cardiometabolic markers; abdominal obesity; sleep duration; stress;
   children
ID CARDIOMETABOLIC RISK-FACTORS; RANDOMIZED CONTROLLED-TRIAL; VIGOROUS
   PHYSICAL-ACTIVITY; BASAL METABOLIC-RATE; BODY-MASS INDEX; SEDENTARY
   TIME; ABDOMINAL ADIPOSITY; CARDIOVASCULAR RISK; ENERGY-EXPENDITURE;
   LIPID PROFILE
AB Insufficient sleep can potentially affect both energy intake and energy expenditure, resulting in obesity and reduced cardiometabolic health. The objective of the study was to investigate if habitual sleep duration of 8-to 11-year-olds modifies the effect of free ad libitum school meals on cardiometabolic markers, body composition, dietary intake, and physical activity. For 2 consecutive 3-month periods, this cluster-randomized, controlled, cross-over trial provided 530 children with school meals or usual lunch brought from home. Dietary intake, activity, and sleep were measured simultaneously for 7 consecutive days using dietary records and accelerometers. Short-and long-sleeping children were defined as lower and upper tertile of sleep duration. Body composition, blood pressure, blood lipids, and homeostatic model assessment of insulin resistance (HOMA(IR)) were measured/calculated. Overall, school meals compared with lunch from home had positive effects on physical activity and blood pressure in long-sleeping children and negative effects on body fat in short-sleeping children. Short-sleeping children increased fat mass compared with long-sleeping children by 0.21 (95% confidence interval 0.03-0.38) kg, android fat mass by 0.02 (0.001-0.04) kg, waist circumference by 0.73 (0.23-1.24) cm, blood pressure by 1.5 (0.4-2.6) mm Hg, fat intake by 1.1 (0.2-2.0) percentage of energy, and decreased total physical activity by 7.2 (1.6-12.7) % (all P <= 0.04), while HOMA(IR) and blood lipids were not modified by sleep duration (all P >= 0.32). In conclusion, the susceptibility to increase abdominal adiposity and blood pressure when exposed to dietary changes can potentially be explained by too little sleep, which results in increased caloric intake and reduced physical activity.
C1 [Hjorth, Mads F.; Sjodin, Anders; Dalskov, Stine-Mathilde; Damsgaard, Camilla Trab; Michaelsen, Kim F.; Ritz, Christian; Astrup, Arne] Univ Copenhagen, Fac Sci, Dept Nutr Exercise & Sports, Copenhagen, Denmark.
   [Biltoft-Jensen, Anja; Andersen, Rikke] Tech Univ Denmark, Natl Food Inst, Div Nutr, Soborg, Denmark.
   [Chaput, Jean-Philippe] Childrens Hosp Eastern Ontario Res Inst, HALO Res Grp, Ottawa, ON K1H 8L1, Canada.
C3 University of Copenhagen; Technical University of Denmark; University of
   Ottawa; Children's Hospital of Eastern Ontario
RP Hjorth, MF (corresponding author), Univ Copenhagen, Fac Sci, Dept Nutr Exercise & Sports, Copenhagen, Denmark.
EM madsfiil@nexs.ku.dk
RI Damsgaard, Camilla/B-4866-2015; Astrup, Arne/HZL-1679-2023; Chaput,
   Jean-Philippe/ABE-6307-2020; Michael, Navin/HGF-2322-2022; Sjodin,
   Anders/B-6975-2015; Astrup, Arne/B-1407-2015; Hjorth, Mads/A-1760-2015;
   Ritz, Christian/P-6159-2014
OI Biltoft-Jensen, Anja Pia/0000-0002-6607-7575; Sjodin,
   Anders/0000-0002-6451-3847; Astrup, Arne/0000-0001-8968-8996; Andersen,
   Rikke/0000-0002-5091-6995; Hjorth, Mads/0000-0001-9440-2737; Ritz,
   Christian/0000-0002-5095-0624; Michaelsen, Kim F/0000-0003-0449-0839;
   Chaput, Jean-Philippe/0000-0002-5607-5736; Damsgaard, Camilla
   T/0000-0002-5013-0562
FU Nordea Foundation
FX The study is part of the OPUS project "Optimal well-being, development
   and health for Danish children through a healthy New Nordic Diet",
   supported by a grant from the Nordea Foundation. A complete list of food
   suppliers providing full or partial food sponsorships to the study can
   be found at the following Web site: foodoflife.
   ku.dk/opus/wp/skolemadsprojektet/leverandorer/. Sources of funding and
   donation had no role in the trial design, collection, analysis, or
   interpretation of data or decision to publish. The authors are very
   grateful to the participants and would also like to acknowledge the
   school staff as well as other researchers and staff in the OPUS project.
   Author contributions: M.F.H., C.T.D., S.D., and R.A. coordinated the
   data collection. M.F.H. analyzed the data and wrote the paper. All
   authors participated in planning the study, critically reviewed the
   manuscript, and approved the final manuscript.
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NR 60
TC 13
Z9 14
U1 2
U2 12
PU CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS
PI OTTAWA
PA 65 AURIGA DR, SUITE 203, OTTAWA, ON K2E 7W6, CANADA
SN 1715-5312
EI 1715-5320
J9 APPL PHYSIOL NUTR ME
JI Appl. Physiol. Nutr. Metab.
PD JAN
PY 2016
VL 41
IS 1
BP 33
EP 40
DI 10.1139/apnm-2015-0319
PG 8
WC Nutrition & Dietetics; Physiology; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics; Physiology; Sport Sciences
GA DD6LC
UT WOS:000370034700005
PM 26647154
DA 2025-06-11
ER

PT J
AU Kong, IG
   Lee, HJ
   Kim, SY
   Sim, S
   Choi, HG
AF Kong, Il Gyu
   Lee, Hyo-Jeong
   Kim, So Young
   Sim, Songyong
   Choi, Hyo Geun
TI Physical Activity, Study Sitting Time, Leisure Sitting Time, and Sleep
   Time Are Differently Associated With Obesity in Korean Adolescents A
   Population-Based Study
SO MEDICINE
LA English
DT Article
ID SCHOOL-AGED CHILDREN; SEDENTARY BEHAVIOR; CARDIOMETABOLIC RISK;
   DURATION; HEALTH; TELEVISION; PREVALENCE; OVERWEIGHT; INDICATORS
AB Low physical activity, long leisure sitting time, and short sleep time are risk factors for obesity, but the association with study sitting time is unknown. The objective of this study was to evaluate the association between these factors and obesity.We analyzed the association between physical activity, study sitting time, leisure sitting time, and sleep time and subject weight (underweight, healthy weight, overweight, and obese), using data from a large population-based survey, the 2013 Korea Youth Risk Behavior Web-based Survey. Data from 53,769 participants were analyzed using multinomial logistic regression analyses with complex sampling. Age, sex, region of residence, economic level, smoking, stress level, physical activity, sitting time for study, sitting time for leisure, and sleep time were adjusted as the confounders.Low physical activity (adjusted odds ratios [AORs]=1.03, 1.12) and long leisure sitting time (AORs=1.15, 1.32) were positively associated with overweight and obese. Low physical activity (AOR=1.33) and long leisure sitting time (AOR=1.12) were also associated with underweight. Study sitting time was negatively associated with underweight (AOR=0.86) but was unrelated to overweight (AOR=0.97, 95% confidence interval [CI]=0.91-1.03) and obese (AOR=0.94, 95% CI=0.84-1.04). Sleep time (<6hours; 6hours, <7hours; 7hours, <8hours) was adversely associated with underweight (AORs=0.67, 0.79, and 0.88) but positively associated with overweight (AORs=1.19, 1.17, and 1.08) and obese (AORs=1.33, 1.36, and 1.30) in a dose-response relationship.In adolescents, increasing physical activity, decreasing leisure sitting time, and obtaining sufficient sleep would be beneficial in maintaining a healthy weight. However, study sitting time was not associated with overweight or obese.
C1 [Kong, Il Gyu; Lee, Hyo-Jeong; Choi, Hyo Geun] Hallym Univ, Coll Med, Dept Otorhinolaryngol Head & Neck Surg, Anyang, South Korea.
   [Kim, So Young] Seoul Natl Univ, Coll Med, Dept Otorhinolaryngol Head & Neck Surg, Seoul, South Korea.
   [Sim, Songyong] Hallym Univ, Dept Stat, Chunchon, South Korea.
C3 Hallym University; Seoul National University (SNU); Hallym University
RP Choi, HG (corresponding author), Hallym Univ, Sacred Heart Hosp, Dept Otorhinolaryngol Head & Neck Surg, 22 Gwanpyeong Ro 170beon Gil, Anyang Si 431796, Gyeonggi Do, South Korea.
EM pupen@naver.com
RI Kim, Yong-Tae/HQZ-0240-2023; Choi, Hyo/K-4461-2019; Lee,
   Hyo-Jeong/AAK-7973-2020
FU Hallym University Sacred Heart Hospital [HURF-2013-02, HURF-2015-06]
FX This work was supported, in part, by a research grant (HURF-2013-02;
   HURF-2015-06) funded by Hallym University Sacred Heart Hospital. We have
   no conflicts of interest.
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NR 32
TC 16
Z9 17
U1 0
U2 14
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD NOV
PY 2015
VL 94
IS 44
AR e1965
DI 10.1097/MD.0000000000001965
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA DC9IX
UT WOS:000369536100047
PM 26554807
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Mummidi, S
   Farook, VS
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   Diaz-Badillo, A
   Fowler, SP
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   Lehman, DM
   Jenkinson, CP
   Arya, R
   Lynch, JL
   Canas, JA
   DeFronzo, RA
   Hale, DE
   Blangero, J
   Lopez-Alvarenga, JC
   Duggirala, R
   Vanamala, JKP
AF Mummidi, Srinivas
   Farook, Vidya S.
   Reddivari, Lavanya
   Hernandez-Ruiz, Joselin
   Diaz-Badillo, Alvaro
   Fowler, Sharon P.
   Resendez, Roy G.
   Akhtar, Feroz
   Lehman, Donna M.
   Jenkinson, Christopher P.
   Arya, Rector
   Lynch, Jane L.
   Canas, Jose A.
   DeFronzo, Ralph A.
   Hale, Daniel E.
   Blangero, John
   Lopez-Alvarenga, Juan Carlos
   Duggirala, Ravindranath
   Vanamala, Jairam K. P.
TI Serum carotenoids and Pediatric Metabolic Index predict insulin
   sensitivity in Mexican American children
SO SCIENTIFIC REPORTS
LA English
DT Article
ID INTERINDIVIDUAL VARIABILITY; CARDIOVASCULAR-DISEASE; CHILDHOOD OBESITY;
   OXIDATIVE STRESS; HUMAN HEALTH; VITAMIN-E; DIETARY; ANTIOXIDANTS;
   LYCOPENE; FRUIT
AB High concentrations of carotenoids are protective against cardiometabolic risk traits (CMTs) in adults and children. We recently showed in non-diabetic Mexican American (MA) children that serum alpha-carotene and beta-carotene are inversely correlated with obesity measures and triglycerides and positively with HDL cholesterol and that they were under strong genetic influences. Additionally, we previously described a Pediatric Metabolic Index (PMI) that helps in the identification of children who are at risk for cardiometabolic diseases. Here, we quantified serum lycopene and beta-cryptoxanthin concentrations in approximately 580 children from MA families using an ultraperformance liquid chromatography-photodiode array and determined their heritabilities and correlations with CMTs. Using response surface methodology (RSM), we determined two-way interactions of carotenoids and PMI on Matsuda insulin sensitivity index (ISI). The concentrations of lycopene and beta-cryptoxanthin were highly heritable [h(2) = 0.98, P = 7 x 10(-18) and h(2) = 0.58, P = 1 x 10(-7)]. We found significant (P <= 0.05) negative phenotypic correlations between beta-cryptoxanthin and five CMTs: body mass index (- 0.22), waist circumference (- 0.25), triglycerides (- 0.18), fat mass (- 0.23), fasting glucose (- 0.09), and positive correlations with HDL cholesterol (0.29). In contrast, lycopene only showed a significant negative correlation with fasting glucose (- 0.08) and a positive correlation with HDL cholesterol (0.18). Importantly, we found that common genetic influences significantly contributed to the observed phenotypic correlations. RSM showed that increased serum concentrations of alpha- and beta-carotenoids rather than that of beta-cryptoxanthin or lycopene had maximal effects on ISI. In summary, our findings suggest that the serum carotenoids are under strong additive genetic influences and may have differential effects on susceptibility to CMTs in children.
C1 [Mummidi, Srinivas; Farook, Vidya S.; Diaz-Badillo, Alvaro; Resendez, Roy G.; Akhtar, Feroz; Jenkinson, Christopher P.; Arya, Rector; Blangero, John; Lopez-Alvarenga, Juan Carlos; Duggirala, Ravindranath] Univ Texas Rio Grande Valley, Sch Med, South Texas Diabet & Obes Inst, Dept Human Genet, Edinburg, TX 78539 USA.
   [Reddivari, Lavanya] Purdue Univ, Dept Food Sci, Smith Hall, W Lafayette, IN 47907 USA.
   [Hernandez-Ruiz, Joselin] Hosp Gen Mexico Dr Eduardo Liceaga, Clin Pharmacol Unit, Mexico City, DF, Mexico.
   [Fowler, Sharon P.] Univ Texas Hlth Houston, Sch Publ Hlth, Houston, TX USA.
   [Lehman, Donna M.; DeFronzo, Ralph A.] Univ Texas Hlth San Antonio, Sch Med, Dept Med, San Antonio, TX USA.
   [Lynch, Jane L.] Univ Texas Hlth San Antonio, Sch Med, Dept Pediat, San Antonio, TX USA.
   [Canas, Jose A.] Johns Hopkins All Childrens Hosp, St Petersburg, FL 33701 USA.
   [Hale, Daniel E.] Penn State Hlth Milton S Hershey Med Ctr, Dept Pediat, Hershey, PA USA.
   [Vanamala, Jairam K. P.] Penn State Univ, Dept Food Sci, University Pk, PA 16802 USA.
   [Vanamala, Jairam K. P.] Penn State Univ, Dept Plant Sci, University Pk, PA 16802 USA.
C3 University of Texas System; University of Texas Rio Grande Valley;
   Purdue University System; Purdue University; University of Texas System;
   University of Texas Health Science Center Houston; University of Texas
   School Public Health; University of Texas System; University of Texas
   Health Science Center at San Antonio; University of Texas System;
   University of Texas Health Science Center at San Antonio; Johns Hopkins
   University; Johns Hopkins Medicine; Pennsylvania Commonwealth System of
   Higher Education (PCSHE); Pennsylvania State University; Penn State
   Health; Pennsylvania Commonwealth System of Higher Education (PCSHE);
   Pennsylvania State University; Penn State Behrend; Pennsylvania State
   University - University Park; Pennsylvania Commonwealth System of Higher
   Education (PCSHE); Pennsylvania State University; Penn State Behrend;
   Pennsylvania State University - University Park
RP Mummidi, S (corresponding author), Univ Texas Rio Grande Valley, Sch Med, South Texas Diabet & Obes Inst, Dept Human Genet, Edinburg, TX 78539 USA.; Vanamala, JKP (corresponding author), Penn State Univ, Dept Food Sci, University Pk, PA 16802 USA.; Vanamala, JKP (corresponding author), Penn State Univ, Dept Plant Sci, University Pk, PA 16802 USA.
EM srinivas.mummidi@utrgv.edu; jairam.vanamala@gmail.com
RI Blangero, John/ABA-7175-2021; Mummidi, Srinivas/H-3335-2017;
   Diaz-Badillo, Alvaro/E-5978-2019; Canas, Jose/Y-8500-2019; Canas,
   Jose/F-3193-2017
OI Lehman, Donna/0000-0001-8547-9927; Akhtar, Feroz/0009-0009-1381-3856;
   Mummidi, Srinivas/0000-0002-4068-6380; Hernandez Ruiz,
   Joselin/0000-0002-0571-2563; Lopez-Alvarenga, Juan/0000-0002-0966-8766;
   Canas, Jose/0000-0003-4788-8820
FU National Institute of Health [R01 HD049051, R01 AI119131, HD049051-5S1,
   HD041111, DK053889, DK047482, P01 HL45522, MH59490]; Veterans
   Administration Epidemiologic Grant; Voelcker Foundation; U.S.D.A.
   National Institute for Food and Agriculture [2009-5520005197]
FX This study was supported by grants from the National Institute of Health
   (R01 HD049051, R01 AI119131, HD049051-5S1 (A.R.R.A.), HD041111,
   DK053889, DK047482, P01 HL45522 and MH59490), Veterans Administration
   Epidemiologic Grant, Voelcker Foundation, and the National Research
   Initiative Grant 2009-5520005197 from the U.S.D.A. National Institute
   for Food and Agriculture. We thank Dr. William Rogers, Dr. Rolando
   Lozano, Dr. Richard Granato, Margaret Fragoso, David Rupert, Rhonda
   Lyons, Tanya Prado, and Ram Prasad Upadhyay for their excellent help and
   assistance. We thank the University Health System and the Texas Diabetes
   Institute for extending their clinical research facilities to the SAFARI
   study. We warmly thank the participants of the SAFARI Study for their
   enthusiasm and cooperation.
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NR 79
TC 7
Z9 7
U1 0
U2 5
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD JAN 13
PY 2021
VL 11
IS 1
AR 871
DI 10.1038/s41598-020-79387-8
PG 11
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA QM4QN
UT WOS:000621765000024
PM 33441626
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Pervanidou, P
   Margeli, A
   Akalestos, A
   Sakka, S
   Kanaka-Gantenbein, C
   Papassotiriou, I
   Chrousos, GP
AF Pervanidou, P.
   Margeli, A.
   Akalestos, A.
   Sakka, S.
   Kanaka-Gantenbein, C.
   Papassotiriou, I.
   Chrousos, G. P.
TI Associations Between Circulating N-terminal pro-Brain Natriuretic
   Peptide (NT-proBNP) and Adiponectin Concentrations Depend on Obesity
   Level in Female Adolescents: Gender Dimorphic Findings
SO HORMONE AND METABOLIC RESEARCH
LA English
DT Article
DE NT-proBNP; adiponectin; puberty; BMI; gender
ID ADIPOSE-SPECIFIC PROTEIN; HEART-FAILURE; PLASMA-CONCENTRATIONS; INSULIN
   SENSITIVITY; DISEASE; HYPOADIPONECTINEMIA; OVERWEIGHT; STRESS; MARKER;
   DIET
AB N-terminal pro-Brain Natriuretic Peptide (NT-proBNP) is an established biomarker for heart failure in adults, while its plasma concentrations are altered in adult obesity. Plasma adiponectin concentrations are decreased in obesity and low levels are associated with disorders with an increased cardiometabolic risk. A few studies support an association between these two markers in adults with coronary heart disease. Such relations have not been investigated in children with obesity, which is the most prevalent risk factor for cardiovascular disease. Ninety-six children, 24 obese/25 normal BMI boys, and 23 obese/24 normal BMI girls, aged 10-16, were studied. Plasma NT-proBNP was measured using electrochemiluminescence, and adiponectin and other metabolic risk factors, such as glucose, insulin, cholesterol, triglycerides (TG), HDL, and LDL using standard methodology. The findings were gender dimorphic. In overweight and obese females (mean BMI z-score: 2.65 +/- 1.69), plasma NT-proBNP concentrations correlated significantly with adiponectin levels (r=0.4, r(2) =0.05, p=0.013), while in those with obesity defined as BMI z-score >2.5 (mean BMI z-score: 3.67 +/- 1.08, n=20) this association was stronger (r=0.13, r(2)=0.22, p=0.005). Adiponectin also correlated significantly with BMI z-scores, TG, HDL, and insulin levels. In boys, there was no correlation between NT-proBNP and adiponectin. NT-proBNP correlated significantly with HDL, while adiponectin correlated with TG, fasting insulin, and the Homeostasis Assessment Model (HOMA) Index. The positive association between NT-proBNP and adiponectin depends on the severity of obesity and is gender dimorphic. This positive correlation in females might be a potential protective mechanism against atherosclerosis in later life.
C1 [Pervanidou, P.; Sakka, S.; Kanaka-Gantenbein, C.; Chrousos, G. P.] Univ Athens, Sch Med, Aghia Sophia Childrens Hosp, Childhood & Adolescent Obes Clin,Dept Pediat 1, GR-11527 Athens, Greece.
   [Margeli, A.; Akalestos, A.; Papassotiriou, I.] Aghia Sophia Childrens Hosp, Dept Clin Biochem, Athens, Greece.
   [Akalestos, A.] Roche Diagnost SA, Roche Hellas, Amaroussion, Greece.
C3 Athens Medical School; The Aghia Sophia Children's Hospital; National &
   Kapodistrian University of Athens; The Aghia Sophia Children's Hospital;
   Roche Holding; ROCHE HOLDING GREECE
RP Pervanidou, P (corresponding author), Univ Athens, Sch Med, Aghia Sophia Childrens Hosp, Childhood & Adolescent Obes Clin,Dept Pediat 1, Thivon & Levadias St, GR-11527 Athens, Greece.
EM ppervanid@med.uoa.gr
RI Pervanidou, Panagiota/ABI-6356-2020; Chrousos, George/G-8702-2011;
   Sakka, Sophia/S-7125-2019; Kanaka-Gantenbein, Christina/AAP-3697-2020
OI Sakka, Sophia/0000-0003-0826-1523; Pervanidou,
   Panagiota/0000-0002-6593-6489
FU A. G. Leventis Foundation, Athens, Greece
FX We would like to thank Roche Diagnostics, Athens, Greece for providing
   reagents for NT-proBNP determinations. Funding was received from the A.
   G. Leventis Foundation, Athens, Greece (to G. C.). The funding sources
   played no role in the study design; in the collection, analysis, and
   interpretation of data; in the writing of the report; or in the decision
   to submit the report for publication.
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NR 29
TC 13
Z9 13
U1 0
U2 3
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0018-5043
EI 1439-4286
J9 HORM METAB RES
JI Horm. Metab. Res.
PD NOV
PY 2009
VL 41
IS 11
BP 829
EP 833
DI 10.1055/s-0029-1233459
PG 5
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 525UU
UT WOS:000272242700006
PM 19670155
DA 2025-06-11
ER

PT J
AU Kouvari, M
   Panagiotakos, DB
   Chrysohoou, C
   Yannakoulia, M
   Georgousopoulou, EN
   Tousoulis, D
   Pitsavos, C
AF Kouvari, M.
   Panagiotakos, D. B.
   Chrysohoou, C.
   Yannakoulia, M.
   Georgousopoulou, E. N.
   Tousoulis, D.
   Pitsavos, C.
CA ATTICA Study Investigators
TI Dietary vitamin D intake, cardiovascular disease and cardiometabolic
   risk factors: a sex-based analysis from the ATTICA cohort study
SO JOURNAL OF HUMAN NUTRITION AND DIETETICS
LA English
DT Article
DE calcitriol; cardiovascular diseases; gender; nutrition; vitamin D
ID SERUM 25-HYDROXYVITAMIN D; ALL-CAUSE MORTALITY; D SUPPLEMENTATION;
   OXIDATIVE STRESS; GLYCEMIC CONTROL; BLOOD-PRESSURE; METAANALYSIS;
   ASSOCIATION; PREVENTION; PARTICIPANTS
AB Background The present study aimed to evaluate the association between dietary vitamin D intake and 10-year first fatal/nonfatal cardiovascular disease (CVD), conventional CVD risk factors and surrogate markers related to inflammation, coagulation, insulin resistance, liver and renal function.
   Methods The ATTICA study was conducted during 2001-2012 including 1514 men and 1528 women (aged >18 years) from the greater Athens area, Greece. Dietary assessment was based on a validated semi-quantitative food frequency questionnaire. Daily intake of vitamin D was calculated using a standardised food database. Follow-up (2011-2012) was achieved in 2020 participants (n = 317 cases).
   Results Ranking from first to third vitamin D tertile, CVD events were 24%, 17% and 12% for men (P = 0.002) and 14%, 10% and 11% for women (P = 0.59). Inverse associations between vitamin D and CVD in total sample [hazard ratio (HR) = 0.76 95% confidence interval (CI) = 0.60-0.97] and in men (HR = 0.66 95% CI = 0.49-0.89) were observed, and lost after adjusting for inflammation/coagulation markers; for women, no significant trends were observed. Regarding 10-year onset of conventional risk factors, inverse associations of vitamin D with hypertension in men (HR = 0.62 95% CI = 0.39-0.99) and transition to metabolically unhealthy status in women (HR = 0.69 95% CI = 0.51-0.93) were observed. Significant inverse associations for C-reactive protein, interleukin-6 and fibrinogen in both sexes, whereas these were revealed only in women for insulin resistance.
   Conclusions Contradicting the neutral/modest associations in vitamin-D supplementation trials, increased food-generated vitamin D may protect against hard and intermediate CVD endpoints, implying different paths between sexes.
C1 [Kouvari, M.; Panagiotakos, D. B.; Yannakoulia, M.; Georgousopoulou, E. N.] Harokopio Univ, Sch Hlth Sci & Educ, Dept Nutr & Dietet, 70 Eleftheriou Venizelou Ave, Athens 17671, Kallithea, Greece.
   [Panagiotakos, D. B.] Univ Canberra, Fac Hlth, Canberra, ACT, Australia.
   [Chrysohoou, C.; Tousoulis, D.; Pitsavos, C.] Univ Athens, Sch Med, Cardiol Clin 1, Athinon, Greece.
   [Georgousopoulou, E. N.] Univ Notre Dame, Sch Med, Sydney, NSW, Australia.
C3 Harokopio University Athens; University of Canberra; National &
   Kapodistrian University of Athens; The University of Notre Dame
   Australia
RP Panagiotakos, DB (corresponding author), Harokopio Univ, Sch Hlth Sci & Educ, Dept Nutr & Dietet, 70 Eleftheriou Venizelou Ave, Athens 17671, Kallithea, Greece.; Panagiotakos, DB (corresponding author), Univ Canberra, Fac Hlth, Collaborat Res Bioactives & Biomarkers CRIBB Grp, Canberra, ACT 2617, Australia.; Panagiotakos, DB (corresponding author), RUTGERS State Univ NJ, Sch Arts & Life Sci, Dept Kinesiol & Hlth, New Brunswick, NJ 08901 USA.
EM dbpanag@hua.gr
RI Kouvari, Matina/P-2308-2017; Georgousopoulou, Ekavi/AAC-2563-2019;
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OI Kouvari, Matina/0000-0002-1558-194X; Georgousopoulou,
   Ekavi/0000-0002-0592-3838; Yannakoulia, Mary/0000-0003-2171-7337;
   Chrysohoou, Christina/0000-0002-6340-3996
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NR 56
TC 13
Z9 14
U1 0
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0952-3871
EI 1365-277X
J9 J HUM NUTR DIET
JI J. Hum. Nutr. Diet.
PD OCT
PY 2020
VL 33
IS 5
BP 708
EP 717
DI 10.1111/jhn.12748
EA APR 2020
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA NP2NZ
UT WOS:000524271800001
PM 32266756
DA 2025-06-11
ER

PT J
AU Hussain, M
   Atif, MA
   Ghafoor, MB
AF Hussain, Mazhar
   Atif, Moazzam Ali
   Ghafoor, Muhammad Bilal
TI Beneficial effects of sitagliptin and metformin in non-diabetic
   hypertensive and dyslipidemic patients
SO PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES
LA English
DT Article
DE Sitagliptin; metformin; dyslipidemia; hypertension; body weight; lipid
   profile
ID DIPEPTIDYL PEPTIDASE-4 INHIBITORS; PEPTIDE-1 RECEPTOR; OXIDATIVE STRESS;
   GLYCEMIC CONTROL; TYPE-2; PIOGLITAZONE; COMBINATION; CANCER
AB Obesity, dyslipidemia and hypertension are major risk factors for cardiovascular disease and its associated complications. To evaluate the beneficial effects of sitagliptin and metfoonin in non-diabetic dyslipidemic and hypertensive patients. A prospective randomized clinical trial was conducted on 70 newly diagnosed dyslipidemic patients with BMI > 25 and blood pressure >130/80 at outpatient clinic of medical unit-1 of sheikh medical college/hospital Rahim Yar Khan. They were divided in to three groups each containing 35 patients; First group served as a healthy control while second and third study groups were given tablet sitagliptin 50mg and tab metformin 850mg respectively twice a day for twelve weeks. After three months treatment with sitagliptin and metformin there was significant reduction in body weight (Sitagliptin 6.5% vs Metformin 7.65%) and BMI (Sitagliptin 2.2% vs Metformin 2.8%) with p <= 0.05. Metformin caused a significant reduction in blood pressure with p <= 0.05 (i.e. SBP 9.9% & DBP 6.4%) while sitagliptin caused a highly significant p <= 0.01 reduction in blood pressure (i.e. SBP 15.8% & DBP 12.2%). There was significant improvement in lipid profile with sitagliptin p <= 0.05. The percent reduction in value of TC, TG and LDL-C was 20.2%, 13.8% and 23.7% while HDL-C value was increased 11.2% respectively. There was highly significant improvement in lipid profile with metformin p <= 0.01. The percent reduction in value of TC, TG and LDL-C was 27.8%, 28.2% and 40.4% while HDL-C value was increased 16.8% respectively. Both drugs improve cardiometabolic risk factors independently in non-diabetic patients.
C1 [Hussain, Mazhar; Atif, Moazzam Ali] Sheikh Zayed Med Coll Hosp, Dept Pharmacol, Rahim Yar Khan, Pakistan.
   [Ghafoor, Muhammad Bilal] Sheikh Zayed Med Coll Hosp, Dept Pathol, Rahim Yar Khan, Pakistan.
RP Hussain, M (corresponding author), Sheikh Zayed Med Coll Hosp, Dept Pharmacol, Rahim Yar Khan, Pakistan.
EM mazharhussain214@gmail.com
RI Hussain, Mazhar/LCD-6123-2024
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NR 38
TC 11
Z9 11
U1 0
U2 1
PU UNIV KARACHI
PI KARACHI
PA UNIV CAMPUS, FAC PHARMACY, KARACHI, 75270, PAKISTAN
SN 1011-601X
J9 PAK J PHARM SCI
JI Pak. J. Pharm. Sci.
PD NOV
PY 2016
VL 29
IS 6
SU S
BP 2385
EP 2389
PG 5
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA EL1UO
UT WOS:000394407000019
PM 28167482
DA 2025-06-11
ER

PT J
AU Rosano, GMC
   Tousoulis, D
   McFadden, E
   Clarke, J
   Davies, GJ
   Kaski, JC
AF Rosano, Giuseppe M. C.
   Tousoulis, Dimitris
   McFadden, Eugene
   Clarke, John
   Davies, Graham J.
   Kaski, Juan Carlos
TI Effects of neuropeptide Y on coronary artery vasomotion in patients with
   microvascular angina
SO INTERNATIONAL JOURNAL OF CARDIOLOGY
LA English
DT Article
DE Syndrome X; Microvascular angina; Coronary reactivity; Neuropeptide Y;
   Left ventricular dysfunction
ID ST-SEGMENT DEPRESSION; SLOW FLOW VELOCITY; SYNDROME-X; VASODILATOR
   RESERVE; PANCREATIC-POLYPEPTIDE; MYOCARDIAL-PERFUSION;
   CARDIAC-HYPERTROPHY; HEART-DISEASE; VASCULAR-TONE; BLOOD-FLOW
AB Background: Patients with microvascular angina (exertional angina, positive exercise tests and normal coronary arteriograms) usually have a reduced coronary blood flow reserve. Neuropeptide Y (NPY) is a potent endogenous vasoconstrictor involved in modulation of coronary vasomotor tone and may play a role in microvascular angina.
   Methods: We compared the effects of NPY (0.2-1.0 pmol/kg, intracoronary) on the vasomotor response of proximal and distal segments of the coronary arteries in 7 patients with microvascular angina, 9 with chronic stable angina, and 9 control individuals. The coronary response to the administration of ergonovine was also assessed in 9 other patients with microvascular angina. Computerized coronary artery diameter measurements were carried out before (baseline) and after the administration of the vasoactive agents.
   Results: Mean baseline coronary lumen diameters were similar in control, microvascular angina, and coronary artery disease patients. NPY constricted proximal coronary segments by 8 +/- 2%, 5 +/- 2% and 6 +/- 3% and distal segments by 14 +/- 2%, 11 +/- 2% and 10 +/- 2% in control, microvascular angina, and coronary artery disease patients, respectively (p = NS between groups). In patients with microvascular angina, ergonovine constricted proximal coronary segments by 7 +/- 1.5% and distal segments by 12.5 +/- 3% (p= NS vs. NPY). During NPY administration four microvascular angina patients developed chest pain, ST segment depression, and amarked lengthening of the contrast medium run off, in the absence of epicardial coronary artery spasm. Control individuals and coronary artery disease patients did not experience chest pain, ST segment shifts, or lengthening of the run off during NPY administration. Ergonovine administration caused chest pain and lengthening of the contrast runoff, in the absence of epicardial coronary artery spasm, in one microvascular angina patient.
   Conclusions: Exogenous NPY causes mild epicardial coronary artery constriction which is similar in patients with non-cardiac chest pain, microvascular angina and coronary artery disease. Myocardial ischemia and marked lengthening of the contrast run off in response to NPY occurred in microvascular angina patients but not in control or coronary artery disease patients. An abnormal constrictor response to NPY at the microcirculation level could be the mechanism underlying the ischemic manifestations observed in patients with microvascular angina.
   Condensed abstract (table of contents): The vasomotor response of proximal and distal coronary artery segments was studied in twenty five patients: 7 microvascular angina, 9 chronic stable angina, and 9 control subjects. Computerized measurements of coronary diameters were carried out before and after the intracoronary administration of neuropeptide Y (NPY) and ergonovine. Constriction of epicardial arteries in response to NPY was mild and not significantly different in control, microvascular angina and coronary artery disease patients. Ergonovine-induced epicardial coronary artery constriction was similar to that of NPY. However, NPY caused transient myocardial ischemia in patients with microvascular angina (probably through constriction of the small intramyocardial vessels), but not in control subjects or coronary artery disease patients. (C) 2017 Elsevier B.V. All rights reserved.
C1 [Rosano, Giuseppe M. C.; Davies, Graham J.; Kaski, Juan Carlos] Univ London, St Georges Hosp, Cardiovasc & Cell Sci Inst, London, England.
   [Rosano, Giuseppe M. C.; Davies, Graham J.; Kaski, Juan Carlos] IRCCS San Raffaele Roma, Dept Med Sci, Rome, Italy.
   [Rosano, Giuseppe M. C.; Tousoulis, Dimitris; Davies, Graham J.; Kaski, Juan Carlos] Hippokrateion Hosp, Athens, Greece.
   [McFadden, Eugene] Cardialysis Core Labs & Clin Trial Management, Rotterdam, Netherlands.
   [McFadden, Eugene] Cork Univ Hosp, Dept Cardiol, Cork, Ireland.
   [Clarke, John] St James Hosp, Dept Cardiol CREST, Dublin, Ireland.
C3 University of London; City St Georges, University of London; IRCCS San
   Raffaele Pisana; Hippokration General Hospital; University College Cork;
   Trinity College Dublin
RP Rosano, GMC (corresponding author), St George Hosp, Sch Med, Cardiovasc & Cell Sci Inst, Cranmer Terrace, London SW17 0RE, England.
EM grosano@sgul.ac.uk
RI Rosano, Giuseppe/K-8718-2018; Kaski, Juan Carlos/LKM-8031-2024
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NR 51
TC 16
Z9 16
U1 0
U2 4
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0167-5273
EI 1874-1754
J9 INT J CARDIOL
JI Int. J. Cardiol.
PD JUL 1
PY 2017
VL 238
BP 123
EP 127
DI 10.1016/j.ijcard.2017.03.024
PG 5
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA EW4NT
UT WOS:000402478900018
PM 28476516
DA 2025-06-11
ER

PT J
AU Ngwa, NE
   Peer, N
   Matsha, TE
   de Villiers, A
   Sobngwi, E
   Kengne, AP
AF Ngwa, Ndonwi Elvis
   Peer, Nasheeta
   Matsha, Tandi E.
   de Villiers, Anniza
   Sobngwi, Eugene
   Kengne, Andre P.
TI Associations of leucocyte telomere length with cardio-metabolic risk
   profile in a South African HIV-infected population
SO MEDICINE
LA English
DT Article
DE Africa; cardiometabolic risk factors; HIV; hypertension; leukocyte
   telomere length; obesity
ID TO-HEIGHT RATIO; CARDIOVASCULAR-DISEASE; INSULIN-RESISTANCE;
   DIABETES-MELLITUS; OXIDATIVE STRESS; HYPERTENSION; OBESITY;
   CLASSIFICATION; DEFINITION; PREVALENCE
AB Leukocyte Telomere length (LTL) is an independent predictor of cardio-metabolic diseases (CMDs) and Human Immuno Virus (HIV) infection. However, studies are lacking on the association between LTL with CMD profile in people with HIV. Accordingly, we investigated the association between LTL and CMD profile in HIV-infected adult South Africans.
   This cross-sectional study included 728 HIV patients (20.6% men; median age 38 years) recruited across 17 public healthcare facilities in Cape Town. CMD markers were compared across quartiles of LTL, and spearman correlations assessed the continuous association of LTL with CMD markers. Linear and logistic regressions were then used to relate LTL with CMD risk profile, with appropriate adjustment for confounders.
   The prevalence of obesity, hypertension and diabetes were 3/1.8%, 36.8%, and 8.4%, respectively. In age, sex and body mass index adjusted models, increasing Log(10)LTL was associated with decreasing systolic (beta=-10.52) and diastolic (beta=-6.74) blood pressures, HOMA-beta (beta=-70.72), increasing total cholesterol (beta=0.544), non-high-density lipoprotein cholesterol (beta=0.472), and waist-to-height-ratio > 0.5 (odds ratio [OR] =5.67), all P < .05. Compared to those in the bottom quarter, those in the top LTL quarter had lower prevalence of hypertension (OR =0.65), and higher prevalence of total cholesterol > 5 mmoVL (OR = 1.94), and low-density lipoprotein-cholesterol > 3 mmoVL (OR =1.62), all P < .05. LTL was not associated with diabetes nor general obesity. It was associated with Alanine Transaminase (ALT) and heart rate in univariable analyses.
   LTL shortening was associated with some CMD risk factors in HIV-infected adults on anti-retroviral therapy in South Africa. Prospective research is needed to explore the direction and implications of these associations.
C1 [Ngwa, Ndonwi Elvis; Matsha, Tandi E.] Cape Peninsula Univ Technol, South African Med Res Council Cape Peninsula Univ, Dept Biomed Sci, Fac Hlth & Wellness Sci, Cape Town, South Africa.
   [Peer, Nasheeta; de Villiers, Anniza; Kengne, Andre P.] South African Med Res Council, Noncommunicable Dis Res Unit, Cape Town, South Africa.
   [Peer, Nasheeta; de Villiers, Anniza; Kengne, Andre P.] South African Med Res Council, Noncommunicable Dis Res Unit, Durban, South Africa.
   [Peer, Nasheeta; Kengne, Andre P.] Univ Cape Town, Dept Med, Fac Hlth Sci, Cape Town, South Africa.
   [Ngwa, Ndonwi Elvis; Sobngwi, Eugene] Univ Yaounde I, Lab Mol Med & Metab, Ctr Biotechnol, Yaounde, Cameroon.
C3 Cape Peninsula University of Technology; South African Medical Research
   Council; South African Medical Research Council; University of Cape
   Town; University of Yaounde I
RP Ngwa, NE (corresponding author), Cape Peninsula Univ Technol, Cape Town, South Africa.
EM ngwaelvis73@gmail.com
RI Kengne, Andre/ABB-3696-2020; De Villiers, Anniza/GQB-3288-2022
OI Sobngwi, Eugene/0000-0001-5457-6572; Kengne, Andre
   Pascal/0000-0002-5183-131X; Peer, Nasheeta/0000-0003-2131-8344
FU Grand Challenges Canada, through the Global Alliance on Chronic Diseases
   Initiative (Hypertension Grant) [0169-04]; South African Medical
   Research Council (SAMRC)
FX This study was supported by Grand Challenges Canada, through the Global
   Alliance on Chronic Diseases Initiative (Hypertension Grant #0169-04);
   and the South African Medical Research Council (SAMRC) through baseline
   allocation to the Non-communicable Diseases Research Unit (NCDRU).
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NR 51
TC 1
Z9 1
U1 0
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD FEB 4
PY 2022
VL 101
IS 5
AR e28642
DI 10.1097/MD.0000000000028642
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA YS9LF
UT WOS:000750992000003
PM 35119008
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Shi, XJ
   Schlenk, EA
AF Shi, Xiaojun
   Schlenk, Elizabeth A.
TI Association of Hypertension with Knee Pain Severity Among People with
   Knee Osteoarthritis
SO PAIN MANAGEMENT NURSING
LA English
DT Article
DE Osteoarthritis, knee; Pain Hypertension
ID METABOLIC SYNDROME; PHYSICAL-ACTIVITY; AMERICAN-COLLEGE; MANAGEMENT;
   HIP; DEPRESSION; INTENSITY; GUIDELINE; ARTHRITIS; BURDEN
AB Purpose: To examine the association of hypertension with knee pain severity in individuals with knee osteoarthritis (OA).
   Design: Cross-sectional study of baseline data collected by the Osteoarthritis Initiative.
   Methods: Participants with knee OA (N=1,363) were categorized into four groups based on blood pressure (BP): 1) systolic < 120 mm HG and diastolic < 80 mm Hg; 2) 120 <= systolic < 130 mm Hg and diastolic < 80 mm Hg; 3) 130 <= systolic < 140 mm Hg or 80 <= diastolic < 90 mm Hg; 4) systolic >= 140 mm Hg or diastolic >= 90 mm Hg. OA knee pain severity was measured by Pain subscale of Western Ontario and McMaster Universities Osteoarthritis Index in the past 48 hours, Pain subscale of Knee Injury and Osteoarthritis Outcome Score (KOOS) in the past 7 days, and numeric rating scale (NRS) in the past 30 days. Linear regression was used to examine the relationship between hypertension and knee pain severity.
   Results: Compared with the normal BP group, individuals with stage 2 hypertension reported significantly higher OA knee pain severity by KOOS in the past 7 days (beta=-2.05 [95% CI -4.09, -0.01], p=0.049) and by NRS in the past 30 days (beta=0.31 [95% CI 0.01, 0.62], p=0.045) after adjustments for demographic and medical factors.
   Conclusions: Hypertension was associated with higher OA knee pain severity in individuals with knee OA.
   Clinical Implications: Nurses can recommend adjunctive non-pharmacological treatments and adherence strategies to help control hypertension, which may help decrease OA knee pain. (C) 2021 American Society for Pain Management Nursing. Published by Elsevier Inc. All rights reserved.
C1 [Shi, Xiaojun; Schlenk, Elizabeth A.] Univ Pittsburgh, Sch Nursing, 3500 Victoria St,Room 415, Pittsburgh, PA 15261 USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE); University
   of Pittsburgh
RP Shi, XJ (corresponding author), Univ Pittsburgh, Sch Nursing, 3500 Victoria St,Room 415, Pittsburgh, PA 15261 USA.
EM xis32@pitt.edu; els100@pitt.edu
OI shi, xiaojun/0000-0001-7095-2996
FU National Institutes of Health, a branch of the U.S. Department of Health
   and Human Services [N01-AR-2-2258, N01-AR-2-2259, N01-AR-2-2260,
   N01-AR-2-2261, N01-AR-2-2262]; Merck Research Laboratories; Novartis
   Pharmaceuticals; GlaxoSmithKline; Pfizer; Foundation for the National
   Institutes of Health
FX The OAI is a public-private partnership comprised of five contracts
   (N01-AR-2-2258;, N01-AR-2-2259;, N01-AR-2-2260;, N01-AR-2-2261;,
   N01-AR-2-2262) funded by the National Institutes of Health, a branch of
   the U.S. Department of Health and Human Services, and conducted by the
   OAI study investigators. Private fund-ing partners include Merck
   Research Laboratories, Novartis Pharmaceuticals, GlaxoSmithKline and
   Pfizer. Private-sector funding for the OAI is managed by the Foundation
   for the National Institutes of Health. This manuscript was prepared
   using an OAI public use dataset and does not necessarily reflect the
   opinions or views of the OAI investigators, the NIH or the private
   funding partners.
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NR 45
TC 14
Z9 14
U1 0
U2 10
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1524-9042
EI 1532-8635
J9 PAIN MANAG NURS
JI Pain Manag. Nurs.
PD APR
PY 2022
VL 23
IS 2
BP 135
EP 141
DI 10.1016/j.pmn.2021.08.002
EA MAR 2022
PG 7
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA ZW4ST
UT WOS:000771205500006
PM 34474997
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Smout, MF
   Manzoni, GM
   Tamini, S
   Marazzi, N
   De Col, A
   Pietrabissa, G
   Castelnuovo, G
   Molinari, E
   Sartorio, A
AF Smout, Matthew F.
   Manzoni, Gian Mauro
   Tamini, Sofia
   Marazzi, Nicoletta
   De Col, Alessandra
   Pietrabissa, Giada
   Castelnuovo, Gianluca
   Molinari, Enrico
   Sartorio, Alessandro
TI Pediatric quality of life multidimensional fatigue scale (PedsQL-MFS)
   detects the effects of a 3-week Inpatient body weight reduction program
   for children and adolescents with obesity
SO HEALTH AND QUALITY OF LIFE OUTCOMES
LA English
DT Article
DE Pediatric obesity; Fatigue; Multidimensional fatigue scale; Body weight
   reduction program
ID METABOLIC SYNDROME; PSYCHOMETRIC PROPERTIES; CHILDHOOD OBESITY;
   OVERWEIGHT; CANCER; INTERVENTIONS; RELIABILITY; DEPRESSION; EXPERIENCE;
   HEIGHT
AB Background Fatigue is a frequent complaint amongst children and adolescents with obesity, and it interferes with adherence to dietary and exercise regimes that could reduce obesity. The present study evaluated the effect of an inpatient 3-week body weight reduction program on body weight and fatigue. Method One hundred children and adolescents with obesity (64% female; aged 11-18 years) undertook an inpatient program of personalized diet, daily exercise, education, and counselling. Results The sample evidenced a mean reduction in body mass (females: Delta M = 4.3 (sd = 2.1) kg, p < .001), males: Delta M = 6.2 (sd = 2.6) kg, p < .001), BMI standard deviation score (females: Delta M = 0.17 (sd = 0.07), males: Delta M = 0.24 (sd = 0.08), p < .001) and fatigue (females: Delta M = 7.8 (sd = 9.7), males: Delta M = 5.0 (sd = 6.9), p < .001) as measured by the Pediatric Quality of Life Multidimensional Fatigue Scale (PedsQL-MFS) and improvements on the Attention problems subscale of the Youth Self Report (total sample: Delta M = 0.89 (sd = 2.44), p < .001). Reliable change analyses revealed fatigue changes were achieved by up to 34% females and 17% males, but the majority did not achieve reliable change and changes in fatigue were not correlated with changes in body mass. Conclusions The program achieved clinically significant improvements in some children and adolescents. Future studies should explore predictors of treatment responsiveness. Trial registration Observational study. Not registered.
C1 [Tamini, Sofia; Marazzi, Nicoletta; De Col, Alessandra; Sartorio, Alessandro] Ist Auxol Italiano IRCCS, Expt Lab Auxoendocrinol Res, Milan, VB, Italy.
   [Tamini, Sofia; Marazzi, Nicoletta; De Col, Alessandra; Sartorio, Alessandro] Ist Auxol Italiano IRCCS, Expt Lab Auxoendocrinol Res, Oggebbio, VB, Italy.
   [Smout, Matthew F.] Univ South Australia, Justice & Soc, Adelaide, SA, Australia.
   [Manzoni, Gian Mauro; Pietrabissa, Giada; Castelnuovo, Gianluca; Molinari, Enrico] Ist Auxol Italiano IRCCS, Psychol Res Lab, Milan, VB, Italy.
   [Manzoni, Gian Mauro; Pietrabissa, Giada; Castelnuovo, Gianluca; Molinari, Enrico] Ist Auxol Italiano IRCCS, Psychol Res Lab, Oggebbio, VB, Italy.
   [Manzoni, Gian Mauro] eCampus Univ, Fac Psychol, Via Isimbardi 10, I-22060 Novedrate, Como, Italy.
   [Pietrabissa, Giada; Castelnuovo, Gianluca; Molinari, Enrico] Catholic Univ Milan, Dept Psychol, Milan, Italy.
   [Sartorio, Alessandro] Ist Auxol Italiano IRCCS, Div Auxol & Metab Dis, Oggebbio, VB, Italy.
C3 IRCCS Istituto Auxologico Italiano; IRCCS Istituto Auxologico Italiano;
   University of South Australia; IRCCS Istituto Auxologico Italiano; IRCCS
   Istituto Auxologico Italiano; Universita Ecampus; Catholic University of
   the Sacred Heart; IRCCS Istituto Auxologico Italiano
RP Manzoni, GM (corresponding author), Ist Auxol Italiano IRCCS, Psychol Res Lab, Milan, VB, Italy.; Manzoni, GM (corresponding author), Ist Auxol Italiano IRCCS, Psychol Res Lab, Oggebbio, VB, Italy.; Manzoni, GM (corresponding author), eCampus Univ, Fac Psychol, Via Isimbardi 10, I-22060 Novedrate, Como, Italy.
EM gianmauro.manzoni@uniecampus.it
RI Manzoni, Gian/L-3891-2019; Marazzi, Nicoletta/AAA-3548-2020; Smout,
   Matthew/AAR-8861-2021; Tamini, Sofia/AAA-3009-2020; Sartorio,
   Alessandro/AAA-3581-2020; Castelnuovo, Gianluca/AAC-1780-2019;
   Pietrabissa, Giada/AAA-2056-2019
OI Sartorio, Alessandro/0000-0002-9620-4133; Castelnuovo,
   Gianluca/0000-0003-2633-9822; Smout, Matthew/0000-0002-6952-6014;
   Marazzi, Nicoletta/0000-0002-1202-4988; Pietrabissa,
   Giada/0000-0002-5911-5748; Manzoni, Gian Mauro/0000-0003-3384-0359
FU Progetti di Ricerca Corrente, Istituto Auxologico Italiano, IRCCS,
   Milan, Italy
FX The study was supported by Progetti di Ricerca Corrente, Istituto
   Auxologico Italiano, IRCCS, Milan, Italy.
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NR 70
TC 7
Z9 8
U1 0
U2 5
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1477-7525
J9 HEALTH QUAL LIFE OUT
JI Health Qual. Life Outcomes
PD JAN 10
PY 2022
VL 20
IS 1
AR 3
DI 10.1186/s12955-021-01907-5
PG 10
WC Health Care Sciences & Services; Health Policy & Services
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services
GA YE2SV
UT WOS:000740981000001
PM 35012568
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Bates, KA
   Sohrabi, HR
   Rainey-Smith, SR
   Weinborn, M
   Bucks, RS
   Rodrigues, M
   Beilby, J
   Howard, M
   Taddei, K
   Martins, G
   Paton, A
   Shah, T
   Dhaliwal, SS
   Foster, JK
   Martins, IJ
   Lautenschlager, NT
   Mastaglia, FL
   Gandy, SE
   Martins, RN
AF Bates, Kristyn A.
   Sohrabi, Hamid R.
   Rainey-Smith, Stephanie R.
   Weinborn, Michael
   Bucks, Romola S.
   Rodrigues, Mark
   Beilby, John
   Howard, Matthew
   Taddei, Kevin
   Martins, Georgia
   Paton, Athena
   Shah, Tejal
   Dhaliwal, Satvinder S.
   Foster, Jonathan K.
   Martins, Ian J.
   Lautenschlager, Nicola T.
   Mastaglia, Frank L.
   Gandy, Samuel E.
   Martins, Ralph N.
TI Serum high-density lipoprotein is associated with better cognitive
   function in a cross-sectional study of aging women
SO INTERNATIONAL JOURNAL OF NEUROSCIENCE
LA English
DT Article
DE memory; apolipoprotein E; ageing; high-density lipoprotein; cognitive
   function; women
ID SUBJECTIVE MEMORY COMPLAINTS; HUMAN APOLIPOPROTEIN-E;
   CORONARY-HEART-DISEASE; AMYLOID-BETA-PEPTIDE; QUALITY-OF-LIFE;
   ALZHEIMERS-DISEASE; OLDER-ADULTS; RISK-FACTORS; FOLLOW-UP; METABOLIC
   SYNDROME
AB Purpose/Aim of the study: Poor cardiovascular health, including obesity and altered lipid profiles at mid-life, are linked to increased risk of Alzheimer's disease (AD). The biological mechanisms linking cardiovascular health and cognitive function are unclear though are likely to be multifactorial. This study examined the association between various lipoproteins and cognitive functioning in ageing women. Materials and Methods: We investigated the relationship between readily available biomarkers (i.e. serum lipoprotein) and cognitive decline in domains associated with increased risk of AD (e.g. episodic verbal memory performance and subjective memory complaint). We report cross-sectional data investigating the relationship between serum total cholesterol, triglycerides, high-density lipoprotein (HDL-C) and low-density lipoprotein with verbal memory and learning ability in 130 women with and without memory complaints (n= 71 and 59, respectively) drawn from a study investigating cognitively healthy Western Australians (average age 62.5 years old). Results: After statistical modelling that controlled for the effects of age, depression and apolipoprotein E genotype, HDL-C was significantly associated with better verbal learning and memory performance, specifically short and long delay-free recalls (F= 3.062; p < .05 and F= 3.2670; p < .05, respectively). Conclusion: Our cross-sectional findings suggest that the positive effect of HDL-C on verbal memory may be present much earlier than previously reported and provide further support for the role of HDL-C in healthy brain ageing. Further exploration of the protective effect of HDL-C on cognitive function in ageing is warranted through follow-up, longitudinal studies.
C1 [Bates, Kristyn A.; Sohrabi, Hamid R.; Rainey-Smith, Stephanie R.; Weinborn, Michael; Rodrigues, Mark; Howard, Matthew; Taddei, Kevin; Martins, Georgia; Paton, Athena; Martins, Ian J.; Martins, Ralph N.] Edith Cowan Univ, Sch Med & Hlth Sci, Joondalup, Australia.
   [Bates, Kristyn A.; Sohrabi, Hamid R.; Rainey-Smith, Stephanie R.; Weinborn, Michael; Rodrigues, Mark; Taddei, Kevin; Martins, Georgia; Shah, Tejal; Martins, Ian J.; Martins, Ralph N.] McCusker Alzheimers Res Fdn, Nedlands, WA, Australia.
   [Bates, Kristyn A.; Sohrabi, Hamid R.; Lautenschlager, Nicola T.; Martins, Ralph N.] Univ Western Australia, Sch Psychiat & Clin Neurosci M650, Crawley, Australia.
   [Sohrabi, Hamid R.] Cooperat Res Ctr Mental Hlth, Carlton, Vic, Australia.
   [Weinborn, Michael; Bucks, Romola S.] Univ Western Australia, Sch Psychol M347, Crawley, Australia.
   [Beilby, John] Univ Western Australia, Sch Pathol & Lab Med M576, Crawley, Australia.
   [Beilby, John] PathWest Lab Med WA, Nedlands, WA, Australia.
   [Dhaliwal, Satvinder S.] Curtin Univ Technol, Sch Publ Hlth, Perth, WA, Australia.
   [Foster, Jonathan K.] Curtin Univ Technol, Sch Psychol & Speech Pathol, Perth, WA, Australia.
   [Lautenschlager, Nicola T.] Univ Melbourne, Acad Unit Psychiat Old Age, Dept Psychiat, St Vincents Hlth, Kew, Australia.
   [Lautenschlager, Nicola T.] Univ Western Australia, WA Ctr Hlth & Aging M577, Crawley, Australia.
   [Mastaglia, Frank L.] Murdoch Univ, Inst Immunol & Infect Dis, Murdoch, WA, Australia.
   [Gandy, Samuel E.] Icahn Sch Med Mt Sinai, Dept Neurol, New York, NY 10029 USA.
   [Gandy, Samuel E.] Icahn Sch Med Mt Sinai, Dept Psychiat, New York, NY 10029 USA.
   [Gandy, Samuel E.] Icahn Sch Med Mt Sinai, Alzheimers Dis Res Ctr, New York, NY 10029 USA.
   [Bates, Kristyn A.] Univ Western Australia, Sch Anim Biol M317, 35 Stirling Hwy, Crawley, WA 6009, Australia.
C3 Edith Cowan University; University of Western Australia; Cooperative
   Research Centre for Mental Health; University of Western Australia;
   University of Western Australia; Curtin University; Curtin University;
   University of Melbourne; University of Western Australia; Murdoch
   University; Icahn School of Medicine at Mount Sinai; Icahn School of
   Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai;
   University of Western Australia
RP Martins, RN (corresponding author), Edith Cowan Univ, Sch Med Sci, 270 Joondalup Dr, Joondalup, WA 6027, Australia.
EM r.martins@ecu.edu.au
RI Martins, Isabel/KIE-5762-2024; Foster, Jonathan/IRZ-7998-2023; Howard,
   Matt/B-7190-2012; Bucks, Romola/B-9164-2011; Weinborn,
   Michael/H-6068-2014; Sohrabi, Hamid Reza/D-2744-2013
OI Bucks, Romola/0000-0002-4207-4724; Weinborn,
   Michael/0000-0001-7094-9930; Martins, Ian James/0000-0002-2390-1501;
   Sohrabi, Hamid Reza/0000-0001-8017-8682; Beilby,
   John/0000-0002-4915-2254; Lautenschlager, Nicola/0000-0003-4850-7794;
   Shah, Tejal/0000-0002-3069-3835; Rainey-Smith,
   Stephanie/0000-0001-7328-9624; Rodrigues, Mark/0000-0002-5620-8658;
   Martins, Ralph/0000-0002-4828-9363
FU Wyeth; Pfizer; Amicus; Diagenic; Epix; Smart Pharma; Wyeth/Elan; Amicus
   Pharmaceuticals; Raine Medical Research Foundation (Western Australia);
   Neurotrauma Research Program (Western Australia); Edith Cowan
   University, Cooperative Research Centre for Mental Health-Australia;
   Neurotrauma Research Program; McCusker Charitable Foundation (Western
   Australia); National Health and Medical Research Council of Australia
   [324100]; McCusker Alzheimer's Research Foundation Inc.; Hollywood
   Private Hospital; McCusker Charitable Foundation
FX Ralph N. Martins is the founder, and owns stocks of Alzhyme. Hamid R.
   Sohrabi has previously received payments from Wyeth and Pfizer, and
   receives remuneration for ongoing work undertaken as part of the Takeda
   TOMMORROW Study Clinical Trial. Jonathan K. Foster has previously
   received payment from Pfizer. Samuel Gandy is a consultant for, owns
   stock/options in, and/or has received lecture fees from Amicus,
   Diagenic, Epix, Smart Pharma and Wyeth/Elan. Samuel Gandy is also a
   member of the data safety monitoring board for the Alzheimer
   Immunotherapy Alliance and holds a grant from Amicus Pharmaceuticals.
   There are no other actual or potential conflicts of interest. Kristyn A.
   Bates is supported by grants funded by the Raine Medical Research
   Foundation (Western Australia) and the Neurotrauma Research Program
   (Western Australia). Hamid R. Sohrabi is supported by grants and funds
   from Edith Cowan University, Cooperative Research Centre for Mental
   Health-Australia, the Neurotrauma Research Program and the McCusker
   Charitable Foundation (Western Australia). This study was supported by
   the National Health and Medical Research Council of Australia (Grant
   Number: 324100 awarded to Ralph N. Martins), the McCusker Alzheimer's
   Research Foundation Inc., Hollywood Private Hospital, and the McCusker
   Charitable Foundation.
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NR 78
TC 40
Z9 42
U1 0
U2 9
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0020-7454
EI 1563-5279
J9 INT J NEUROSCI
JI Int. J. Neurosci.
PY 2017
VL 127
IS 3
BP 243
EP 252
DI 10.1080/00207454.2016.1182527
PG 10
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology
GA EK2XV
UT WOS:000393791300007
PM 27113638
DA 2025-06-11
ER

PT J
AU Litwin, L
   Sundholm, JKM
   Olander, RFW
   Meinilä, J
   Kulmala, J
   Tammelin, TH
   Rönö, K
   Koivusalo, SB
   Eriksson, JG
   Sarkola, T
AF Litwin, Linda
   Sundholm, Johnny K. M.
   Olander, Rasmus F. W.
   Meinila, Jelena
   Kulmala, Janne
   Tammelin, Tuija H.
   Rono, Kristiina
   Koivusalo, Saila B.
   Eriksson, Johan G.
   Sarkola, Taisto
TI Associations Between Sedentary Time, Physical Activity, and
   Cardiovascular Health in 6-Year-Old Children Born to Mothers With
   Increased Cardiometabolic Risk
SO PEDIATRIC EXERCISE SCIENCE
LA English
DT Article
DE intima-media thickness; echocardiography; cardiovascular risk;
   pediatrics; obesity
ID SCHOOL-AGED CHILDREN; PEDIATRIC ECHOCARDIOGRAM; AMERICAN-SOCIETY;
   HEART-DISEASE; EXERCISE; BEHAVIOR; ADOLESCENTS; PERFORMANCE; VALIDATION;
   INDICATORS
AB Purpose: To assess associations between sedentary time (ST), physical activity (PA), and cardiovascular health in early childhood. Method: Cross-sectional study including 160 children (age 6.1 y [SD 0.5], 86 boys, 93 maternal body mass index >= 30 kg/m(2), and 73 gestational diabetes) assessed for pulse wave velocity, echocardiography, ultra-high frequency 48- 70 MHz vascular ultrasound, and accelerometery. Results: Boys had 385 (SD 53) minutes per day ST, 305 (SD 44) minutes per day light PA, and 81 (SD 22) minutes per day moderate to vigorous PA (MVPA). Girls had 415 (SD 50) minutes per day ST, 283 (SD 40) minutes per day light PA, and 66 (SD 19) minutes per day MVPA. In adjusted analyses, MVPA was inversely associated with resting heart rate (fi = -6.6; 95% confidence interval, -12.5 to -0.7) and positively associated with left ventricular mass (fi = 6.8; 1.4-12.3), radial intima-media thickness (fi = 11.4; 5.4-17.5), brachial intima-media thickness (fi = 8.0; 2.0-14.0), and femoral intima-media thickness (fi = 1.3; 0.2-2.3). MVPA was inversely associated with body fat percentage (fi = -3.4; -6.6 to -0.2), diastolic blood pressure (fi = -0.05; -0.8 to -0.1), and femoral (fi = -18.1; -32.4 to -0.8) and radial (fi = -13.4; -24.0 to -2.9) circumferential wall stress in boys only. ST and pulse wave velocity showed no significant associations. Conclusions: In young at-risk children, MVPA is associated with cardiovascular remodeling, partly in a sex-dependant way, likely representing physiological adaptation, but ST shows no association with cardiovascular health in early childhood.
C1 [Litwin, Linda; Sundholm, Johnny K. M.; Olander, Rasmus F. W.; Sarkola, Taisto] Univ Helsinki, Childrens Hosp, Helsinki, Finland.
   [Litwin, Linda; Sundholm, Johnny K. M.; Olander, Rasmus F. W.; Koivusalo, Saila B.; Eriksson, Johan G.; Sarkola, Taisto] Helsinki Univ Hosp, Helsinki, Finland.
   [Litwin, Linda] Med Univ Silesia, Dept Congenital Heart Defects & Pediat Cardiol, FMS Zabrze, Katowice, Poland.
   [Sundholm, Johnny K. M.; Sarkola, Taisto] Minerva Fdn, Inst Med Res, Helsinki, Finland.
   [Meinila, Jelena] Univ Helsinki, Dept Food & Nutr, Helsinki, Finland.
   [Kulmala, Janne; Tammelin, Tuija H.] Jamk Univ Appl Sci, Sch Hlth & Social Studies, Likes, Jyvaskyla, Finland.
   [Rono, Kristiina] Univ Helsinki, Womens Hosp, Helsinki, Finland.
   [Koivusalo, Saila B.] Univ Turku, Turku Univ Hosp, Turku, Finland.
   [Koivusalo, Saila B.] Turku Univ Hosp, Turku, Finland.
   [Koivusalo, Saila B.] Univ Helsinki, Helsinki, Finland.
   [Eriksson, Johan G.] Folkhalsan Res Ctr, Helsinki, Finland.
   [Eriksson, Johan G.] Univ Helsinki, Dept Gen Practice & Primary Hlth Care, Helsinki, Finland.
   [Eriksson, Johan G.] Natl Univ Singapore, Yong Loo Lin Sch Med, Human Potential Translat Res Programme, Singapore, Singapore.
   [Eriksson, Johan G.] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Obstet & Gynaecol, Singapore, Singapore.
   [Eriksson, Johan G.] ASTAR, Agcy Sci Technol & Res ASTAR, Singapore, Singapore.
C3 University of Helsinki; University of Helsinki; Helsinki University
   Central Hospital; Medical University of Silesia; University of Helsinki;
   Jyvaskyla University of Applied Sciences; University of Helsinki;
   University of Turku; University of Turku; University of Helsinki;
   Folkhalsan Research Center; University of Helsinki; National University
   of Singapore; National University of Singapore; Agency for Science
   Technology & Research (A*STAR)
RP Litwin, L (corresponding author), Univ Helsinki, Childrens Hosp, Helsinki, Finland.; Litwin, L (corresponding author), Helsinki Univ Hosp, Helsinki, Finland.; Litwin, L (corresponding author), Med Univ Silesia, Dept Congenital Heart Defects & Pediat Cardiol, FMS Zabrze, Katowice, Poland.
EM litwinlinda@gmail.com
RI Litwin, Linda/JFA-4628-2023; Gibbs, J. Raphael/A-3984-2010; Tammelin,
   Tuija/JXL-9032-2024; Rono, Kristiina/S-6256-2016; Koivusalo,
   Saila/G-4024-2014
OI Tammelin, Tuija/0000-0002-1771-3977; Meinila,
   Jelena/0000-0002-6377-1377; Sundholm, Johnny/0000-0003-1334-0162;
   Eriksson, Johan/0000-0002-2516-2060; Sarkola,
   Taisto/0000-0002-2590-3279; Rono, Kristiina/0000-0002-6344-1159; Litwin,
   Linda/0000-0002-4761-374X; Koivusalo, Saila/0000-0002-9482-9826;
   Kulmala, Janne/0000-0003-0402-7983
FU Sigrid Juselius Foundation; Medical Society of Finland; Medicinska
   Understdsfreningen Liv och Hlsa; Medicinska Understodsforeningen Liv och
   Halsa; Finnish Foundation for Pediatric Research; Perklen Foundation
FX This study has been supported by grants from the Sigrid Juselius
   Foundation, the Medical Society of Finland, Medicinska
   Understodsforeningen Liv och Halsa, Finnish Foundation for Pediatric
   Research, and the Perklen Foundation.
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NR 46
TC 0
Z9 0
U1 1
U2 1
PU HUMAN KINETICS PUBL INC
PI CHAMPAIGN
PA 1607 N MARKET ST, PO BOX 5076, CHAMPAIGN, IL 61820-2200 USA
SN 0899-8493
EI 1543-2920
J9 PEDIATR EXERC SCI
JI Pediatr. Exerc. Sci.
PD AUG
PY 2024
VL 36
IS 3
BP 146
EP 154
DI 10.1123/pes.2023-0058
EA DEC 2023
PG 9
WC Pediatrics; Physiology; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics; Physiology; Sport Sciences
GA D1G9K
UT WOS:001136702900001
PM 38154001
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Li, KL
   Sinclair, AJ
   Zhao, F
   Li, D
AF Li, Kelei
   Sinclair, Andrew J.
   Zhao, Feng
   Li, Duo
TI Uncommon Fatty Acids and Cardiometabolic Health
SO NUTRIENTS
LA English
DT Review
DE furan fatty acids; docosapentaenoic acid; conjugated fatty acids;
   cardiovascular disease; metabolic disease; blood lipids; inflammation;
   antioxidant
ID CONJUGATED LINOLEIC-ACID; LONG-CHAIN OMEGA-3-FATTY-ACIDS; POMEGRANATE
   SEED OIL; DISEASE RISK-FACTORS; CARDIOVASCULAR-DISEASE; DOCOSAPENTAENOIC
   ACID; EICOSAPENTAENOIC ACID; LIPID-PEROXIDATION; INSULIN SENSITIVITY;
   OXIDATIVE STRESS
AB Cardiovascular disease (CVD) is a major cause of mortality. The effects of several unsaturated fatty acids on cardiometabolic health, such as eicosapentaenoic acid (EPA) docosahexaenoic acid (DHA), linolenic acid (ALA), linoleic acid (LA), and oleic acid (OA) have received much attention in past years. In addition, results from recent studies revealed that several other uncommon fatty acids (fatty acids present at a low content or else not contained in usual foods), such as furan fatty acids, n-3 docosapentaenoic acid (DPA), and conjugated fatty acids, also have favorable effects on cardiometabolic health. In the present report, we searched the literature in PubMed, Embase, and the Cochrane Library to review the research progress on anti-CVD effect of these uncommon fatty acids. DPA has a favorable effect on cardiometabolic health in a different way to other long-chain n-3 polyunsaturated fatty acids (LC n-3 PUFAs), such as EPA and DHA. Furan fatty acids and conjugated linolenic acid (CLNA) may be potential bioactive fatty acids beneficial for cardiometabolic health, but evidence from intervention studies in humans is still limited, and well-designed clinical trials are required. The favorable effects of conjugated linoleic acid (CLA) on cardiometabolic health observed in animal or in vitro cannot be replicated in humans. However, most intervention studies in humans concerning CLA have only evaluated its effect on cardiometabolic risk factors but not its direct effect on risk of CVD, and randomized controlled trials (RCTs) will be required to clarify this point. However, several difficulties and limitations exist for conducting RCTs to evaluate the effect of these fatty acids on cardiometabolic health, especially the high costs for purifying the fatty acids from natural sources. This review provides a basis for better nutritional prevention and therapy of CVD.
C1 [Li, Kelei; Zhao, Feng; Li, Duo] Qingdao Univ, Inst Nutr & Hlth, Qingdao 266021, Peoples R China.
   [Sinclair, Andrew J.] Deakin Univ, Fac Hlth, Locked Bag 20000, Geelong, Vic 3220, Australia.
   [Sinclair, Andrew J.; Li, Duo] Monash Univ, Dept Nutr Dietet & Food, Notting Hill, Vic 3168, Australia.
C3 Qingdao University; Deakin University; Monash University
RP Li, D (corresponding author), Qingdao Univ, Inst Nutr & Hlth, Qingdao 266021, Peoples R China.; Li, D (corresponding author), Monash Univ, Dept Nutr Dietet & Food, Notting Hill, Vic 3168, Australia.
EM likelei@qdu.edu.cn; andrew.sinclair@deakin.edu.au; fzhao@qdu.edu.cn;
   duoli@qdu.edu.cn
RI Li, Duo/N-3682-2013
OI Li, Duo/0000-0001-5227-5565
FU National Basic Research Program of China (973 Program) [2015CB553604];
   National Natural Science Foundation of China [NSFC: 81773433]; Key
   Scientific Research Projects in Shandong Province China [2017YYSP007];
   China postdoctoral Science Foundation [2018M630760]; Qingdao
   Postdoctoral Application Research Project
FX This research was funded by the National Basic Research Program of China
   (973 Program: 2015CB553604), the National Natural Science Foundation of
   China (NSFC: 81773433), the Key Scientific Research Projects in Shandong
   Province China (2017YYSP007), the China postdoctoral Science Foundation
   (2018M630760), and the Qingdao Postdoctoral Application Research
   Project.
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NR 105
TC 40
Z9 44
U1 4
U2 33
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 2072-6643
J9 NUTRIENTS
JI Nutrients
PD OCT
PY 2018
VL 10
IS 10
AR 1559
DI 10.3390/nu10101559
PG 14
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA GY7UM
UT WOS:000448821300225
PM 30347833
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Katsiki, N
   Mikhailidis, DP
   Theodorakis, MJ
AF Katsiki, Niki
   Mikhailidis, Dimitri P.
   Theodorakis, Michael J.
TI Sodium-glucose Cotransporter 2 Inhibitors (SGLT2i): Their Role in
   Cardiometabolic Risk Management
SO CURRENT PHARMACEUTICAL DESIGN
LA English
DT Review
DE Dapagliflozin; empagliflozin; canagliflozin; sodium-glucose
   cotransporter 2 inhibitors; cardiovascular risk factors; cardiovascular
   outcome trials; renoprotection; microvascular complications
ID TYPE-2 DIABETES-MELLITUS; FATTY LIVER-DISEASE; DIPEPTIDYL PEPTIDASE-4
   INHIBITORS; DAPAGLIFLOZIN REDUCES ALBUMINURIA; LIPOPROTEIN LDL
   SUBCLASSES; GLOMERULAR-FILTRATION-RATE; AMBULATORY BLOOD-PRESSURE;
   IMPROVES GLYCEMIC CONTROL; CHRONIC HEART-FAILURE; ANKLE VASCULAR INDEX
AB Background: Sodium-glucose cotransporter 2 inhibitors (SGLT2i) are a novel category of oral antidiabetic drugs that inhibit renal glucose reabsorption and increase renal glucose excretion, thus lowering plasma glucose levels. This unique mechanism of SGLT2i action is insulin independent, thus improving glycemic control without promoting hypoglycemia in the absence of exogenously administered insulin.
   Methods: The present narrative review addresses the putative associations between SGLT2i and several cardiovascular (CV) and microvascular risk factors, as well as their effects on cardiac and renal function.
   Results: SGLT2i improve several CV risk factors, including fasting and postprandial plasma glucose levels, lipids, blood pressure, body weight, serum uric acid and arterial stiffness. These drugs may also favorably modulate cardiac and renal function via their effects on inflammation, oxidative stress, diuresis, fluid and sodium retention, myocardial function, vascular resistance and 'fuel' metabolism. In the EMPA-REG OUTCOME study, the first published large CV outcome SGLT2i trial, empagliflozin significantly reduced the primary composite outcome (i.e. CV death, nonfatal myocardial infarction or stroke) and all-cause death as well as hospitalization for heart failure. In addition, empagliflozin was associated with a slower progression of kidney disease and lower rates of clinically relevant renal events than was placebo when added to standard care in patients at high CV risk.
   Conclusion: Multiple metabolic benefits may account for the positive clinical outcomes in the EMPA-REG OUTCOME study. Ongoing CV outcome trials involving other SGLT2i will help establish whether the reported CV and microvascular risk benefits are compound-specific or drug class effects.
C1 [Katsiki, Niki] Univ Thessaloniki, Hippocrat Hosp, Med Sch, Propedeut Dept Internal Med 2, Thessaloniki, Greece.
   [Mikhailidis, Dimitri P.] UCL, Med Sch, Dept Clin Biochem, Royal Free Hosp Campus, London, England.
   [Theodorakis, Michael J.] Univ Oxford, Oxford Ctr Diabet Endocrinol & Metab, Diabetes Trials Unit, Oxford, England.
C3 Aristotle University of Thessaloniki; University of London; University
   College London; Royal Free London NHS Foundation Trust; University of
   Oxford
RP Mikhailidis, DP (corresponding author), UCL, Med Sch, Dept Clin Biochem, Royal Free Hosp Campus,Pond St, London NW3 2QG, England.
EM mikhailidis@aol.com
RI Mikhailidis, Dimitri/A-1869-2013; KATSIKI, NIKI/ADE-7999-2022
OI KATSIKI, NIKI/0000-0003-0894-2644
FU Amgen; Angelini; Astra Zeneca; Boehringer Ingelheim; MSD; Novartis; Novo
   Nordisk; Sanofi; Astra-Zeneca; Libytec; Bayer
FX This review was written independently; no company or institution
   supported the authors financially or by providing a professional writer.
   NK has given talks, attended conferences and participated in trials
   sponsored by Amgen, Angelini, Astra Zeneca, Boehringer Ingelheim, MSD,
   Novartis, Novo Nordisk and Sanofi. DPM has given talks and attended
   conferences sponsored by MSD, Astra-Zeneca and Libytec. MJT is the
   clinical lead of a trial funded by Bayer.
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NR 196
TC 52
Z9 55
U1 0
U2 16
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1381-6128
EI 1873-4286
J9 CURR PHARM DESIGN
JI Curr. Pharm. Design
PY 2017
VL 23
IS 10
BP 1522
EP 1532
DI 10.2174/1381612823666170113152742
PG 11
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA EV0LE
UT WOS:000401430400013
PM 28088910
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Sauder, KA
   McCrea, CE
   Ulbrecht, JS
   Kris-Etherton, PM
   West, SG
AF Sauder, Katherine A.
   McCrea, Cindy E.
   Ulbrecht, Jan S.
   Kris-Etherton, Penny M.
   West, Sheila G.
TI Effects of pistachios on the lipid/lipoprotein profile, glycemic
   control, inflammation, and endothelial function in type 2 diabetes: A
   randomized trial
SO METABOLISM-CLINICAL AND EXPERIMENTAL
LA English
DT Article
DE Pistachios; Nuts; Cholesterol; Glycemia; Endothelial function
ID NUT CONSUMPTION; CARDIOVASCULAR-DISEASE; OXIDATIVE STRESS;
   HDL-CHOLESTEROL; LONG-TERM; WALNUTS; RISK; ADULTS; DIETS; COMPONENTS
AB Objective. The health benefits of regular nut consumption have been well-documented; however, effects on cardiovascular risk in diabetes are emerging. This study examined the effects of daily pistachio consumption on the lipid/lipoprotein profile, glycemic control, markers of inflammation, and endothelial function in adults with type 2 diabetes.
   Materials/Methods. We enrolled 30 adults (40-74 years) with well-controlled type 2 diabetes (mean glycated hemoglobin 6.2%) in a randomized, crossover, controlled feeding study. After a 2-week run-in period, participants consumed nutritionally-adequate diets with pistachios (contributing 20% of total energy) or without pistachios for 4 weeks each, separated by a 2-week washout. We assessed fasting lipids/lipoproteins, glycemic measures (while fasted and during a 75 g oral glucose tolerance test), inflammatory markers, and endothelial function after each diet period.
   Results. Total cholesterol and the ratio of total to HDL cholesterol were significantly lower (p < 0.05) following the pistachio diet (4.00 mmol/L and 4.06 mmol/L, respectively) compared to the control diet (4.15 mmol/L and 4.37 mmol/L, respectively). Triglycerides were significantly lower (p = 0.003) following the pistachio diet (1.56 mmol/L) compared to the control diet (1.84 mmol/L). There were no treatment differences in fasting glucose and insulin, but fructosamine was significantly lower (p = 0.03) following the pistachio diet (228.5 mu mol/l) compared to the control diet (233.5 mu mol/l). Inflammatory markers and endothelial function were unchanged.
   Conclusion. Daily pistachio consumption can improve some cardiometabolic risk factors in adults with well-controlled type 2 diabetes. Our findings support recommendations that individuals with diabetes follow healthy dietary patterns that include nuts. (C) 2015 Published by Elsevier Inc.
C1 [Sauder, Katherine A.; McCrea, Cindy E.; Ulbrecht, Jan S.; West, Sheila G.] Penn State Univ, Dept Biobehav Hlth, University Pk, PA 16802 USA.
   [Kris-Etherton, Penny M.; West, Sheila G.] Penn State Univ, Errient Nutr Sci, University Pk, PA 16802 USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE);
   Pennsylvania State University; Penn State Behrend; Pennsylvania State
   University - University Park; Pennsylvania Commonwealth System of Higher
   Education (PCSHE); Pennsylvania State University; Pennsylvania State
   University - University Park; Penn State Behrend
RP West, SG (corresponding author), Penn State Univ, Dept Biobehav Hlth, 219 Biobehav Hlth Bldg, University Pk, PA 16802 USA.
EM sgw2@psu.edu
OI West, Sheila/0000-0003-3488-8768; Kris-Etherton,
   Penny/0000-0001-6012-4900
FU American Pistachio Growers; National Institutes of Health [M01RR10732,
   F31AG043224, T32DK07658]
FX The research was supported by a grant from the American Pistachio
   Growers (SGW, JSU, PMKE) and, in part, by the National Institutes of
   Health (PSU: M01RR10732; KAS: F31AG043224, T32DK07658). The
   organizations that provided funding had no involvement in the
   collection, analysis, or interpretation of the data.
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NR 47
TC 79
Z9 85
U1 0
U2 22
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0026-0495
EI 1532-8600
J9 METABOLISM
JI Metab.-Clin. Exp.
PD NOV
PY 2015
VL 64
IS 11
BP 1521
EP 1529
DI 10.1016/j.metabol.2015.07.021
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA CU3PJ
UT WOS:000363437000018
PM 26383493
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Maurus, I
   Mantel, C
   Keller-Varady, K
   Schmitt, A
   Lembeck, M
   Röh, A
   Papazova, I
   Falkai, P
   Schneider-Axmann, T
   Hasan, A
   Malchow, B
AF Maurus, I.
   Mantel, C.
   Keller-Varady, K.
   Schmitt, A.
   Lembeck, M.
   Roeh, A.
   Papazova, I.
   Falkai, P.
   Schneider-Axmann, T.
   Hasan, A.
   Malchow, B.
TI Resistance training in patients with schizophrenia: Concept and proof of
   principle trial
SO JOURNAL OF PSYCHIATRIC RESEARCH
LA English
DT Article
DE Schizophrenia; Exercise; Resistance; Strength training; GAF
ID METABOLIC SYNDROME; PHYSICAL-EXERCISE; GLOBAL ASSESSMENT; METAANALYSIS;
   SYMPTOMS; STRENGTH; ASSOCIATION; PREVENTION; DEPRESSION; DISORDERS
AB Resistance training has been shown to contribute to the prevention and management of cardiovascular diseases, which is why it can help reducing morbidity and mortality in schizophrenia patients. Moreover, positive effects on different schizophrenia symptom domains have been proposed.
   However, a specific resistance training tailored to the needs of schizophrenia patients and its evaluation is still lacking. The objective in this proof of principle trial was to evaluate the feasibility and efficacy of a newly developed 12-week resistance program according to current recommendations of the WHO and the American College of Sports Medicine. We employed a single blind, parallel assignment clinical trial design with participants randomized to attend either a resistance training including three 50min units per week or a balance and tone program as control condition.
   The primary outcome was the impact on health-related difficulties assessed with the World Health Organization Disability Assessment Schedule (WHO-DAS). Secondary outcome parameters included the level of functioning, schizophrenia symptoms, selected cognitive parameters as well as risk factors for cardiovascular diseases.
   In our proof of principle trial, we could not find significant time or group effects of resistance training on the WHO-DAS. However, we could observe significant positive effects on the level of functioning assessed with the Global Assessment of Functioning Scale (GAF) over the course of time, which were more pronounced in the intervention group. Our findings indicated that patients with schizophrenia could safely participate in resistance training with relevant improvements in their level of functioning. Well-powered replication trials are needed to provide more efficacy data.
C1 [Maurus, I.; Mantel, C.; Schmitt, A.; Lembeck, M.; Roeh, A.; Papazova, I.; Falkai, P.; Schneider-Axmann, T.; Hasan, A.] Ludwig Maximilians Univ Munchen, Univ Hosp, Dept Psychiat & Psychotherapy, Nussbaumstr 7, D-80336 Munich, Germany.
   [Keller-Varady, K.] Hannover Med Sch, Inst Sports Med, Hannover, Germany.
   [Schmitt, A.] Univ Sao Paulo, Inst Psychiat, Lab Neurosci LIM27, Sao Paulo, SP, Brazil.
   [Malchow, B.] Univ Hosp Jena, Dept Psychiat & Psychotherapy, Jena, Germany.
C3 University of Munich; Hannover Medical School; Universidade de Sao
   Paulo; Friedrich Schiller University of Jena
RP Maurus, I (corresponding author), Ludwig Maximilians Univ Munchen, Univ Hosp, Dept Psychiat & Psychotherapy, Nussbaumstr 7, D-80336 Munich, Germany.
EM Isabel.Maurus@med.uni-muenchen.de
RI Malchow, Berend/AAM-9172-2020; Maurus, Isabel/HMO-5534-2023; Falkai,
   Peter/E-3273-2017
OI Falkai, Peter/0000-0003-2873-8667
FU German Research Foundation (DFG): Klinische Forschergruppe (KFO) [241];
   German Research Foundation (DFG): PsyCourse [FA241/16-1]; German Federal
   Ministry of Education and Research (BMBF) through the research network
   on psychiatric diseases ESPRIT [01EE1407E]
FX This research was funded by the following grants from the German
   Research Foundation (DFG): Klinische Forschergruppe (KFO) 241, and
   PsyCourse to PF (FA241/16-1). Further funding was received from the
   German Federal Ministry of Education and Research (BMBF) through the
   research network on psychiatric diseases ESPRIT (grant number 01EE1407E)
   to PF, AH, AS.
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NR 54
TC 8
Z9 8
U1 0
U2 10
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-3956
EI 1879-1379
J9 J PSYCHIATR RES
JI J. Psychiatr. Res.
PD JAN
PY 2020
VL 120
BP 72
EP 82
DI 10.1016/j.jpsychires.2019.09.015
PG 11
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA JS5YB
UT WOS:000500381100009
PM 31634752
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Perry, BI
   Upthegrove, R
   Thompson, A
   Marwaha, S
   Zammit, S
   Singh, SP
   Khandaker, G
AF Perry, Benjamin Ian
   Upthegrove, Rachel
   Thompson, Andrew
   Marwaha, Steven
   Zammit, Stanley
   Singh, Swaran Preet
   Khandaker, Golam
TI Dysglycaemia, Inflammation and Psychosis: Findings From the UK ALSPAC
   Birth Cohort
SO SCHIZOPHRENIA BULLETIN
LA English
DT Article
DE dysglycaemia; insulin resistance; psychosis; risk; schizophrenia;
   inflammation; ALSPAC
ID GENE-ENVIRONMENT INTERACTIONS; HOMEOSTASIS MODEL ASSESSMENT; C-REACTIVE
   PROTEIN; INSULIN-RESISTANCE; METABOLIC SYNDROME; 1ST-EPISODE PSYCHOSIS;
   CUTOFF POINTS; SCHIZOPHRENIA; ASSOCIATION; DEPRESSION
AB Background Psychosis is associated with both dysglycaemia and low-grade inflammation, but population-based studies investigating the interplay between these factors are scarce.
   Aims (1) To explore the direction of association between markers of dysglycaemia, inflammation and psychotic experiences (PEs); and (2) To explore whether dysglycaemia moderates and/or mediates the association between inflammation and PEs.
   Method Data from the Avon Longitudinal Study of Parents and Children (ALSPAC) birth cohort were modeled using logistic and linear regression to examine cross-sectional and longitudinal associations between markers of dysglycaemia (ages 9 and 18), interleukin-6 (IL-6) (age 9), and PEs (ages 12 and 18). We tested for an interaction between dysglycaemia and IL-6 on risk of PEs at age 18, and tested whether dysglycaemia mediated the relationship between IL-6 and PEs.
   Results Based on 2627 participants, at age 18, insulin resistance (IR) was associated with PEs (adjusted OR = 2.32; 95% CI, 1.37-3.97). IR was associated with IL-6 both cross-sectionally and longitudinally. Interaction analyses under a multiplicative model showed that IR moderated the association between IL-6 at age 9 and PEs at age 18 (adjusted OR for interaction term = 2.18; 95% C.I., 1.06-4.49). Mediation analysis did not support a model of IR mediating the relationship between IL-6 and PEs.
   Implications IR is associated with PEs in young people even before the onset of clinical psychosis. Metabolic alterations may interact with childhood inflammation to increase risk of PEs. The findings have implications for clinical practice and future research.
C1 [Perry, Benjamin Ian; Thompson, Andrew; Marwaha, Steven; Singh, Swaran Preet] Coventry & Warwickshire Partnership NHS Trust, Dept Psychiat, Coventry, W Midlands, England.
   [Perry, Benjamin Ian; Thompson, Andrew; Marwaha, Steven; Singh, Swaran Preet] Univ Warwick, Unit Mental Hlth & Wellbeing, Coventry, W Midlands, England.
   [Upthegrove, Rachel] Univ Birmingham, Inst Mental Hlth, Birmingham, W Midlands, England.
   [Upthegrove, Rachel] Birmingham & Solihull Mental Hlth Fdn Trust, Dept Psychiat, Birmingham, W Midlands, England.
   [Zammit, Stanley; Khandaker, Golam] Univ Bristol, Sch Social & Community Med, Ctr Acad Mental Hlth, Bristol, Avon, England.
   [Zammit, Stanley] Cardiff Univ, Med Res Council Ctr Neuropsychiat Genet & Genom, Inst Psychol Med & Clin Neurosci, Cardiff, S Glam, Wales.
   [Khandaker, Golam] Univ Cambridge, Dept Psychiat, Cambridge, England.
   [Khandaker, Golam] Natl Inst Hlth Res Cambridge Biomed Res Ctr, Cambridge, England.
   [Khandaker, Golam] Cambridgeshire & Peterborough Natl Hlth Serv Fdn, Dept Psychiat, Cambridge, England.
C3 University of Warwick; University of Birmingham; University of Bristol;
   Cardiff University; University of Cambridge
RP Perry, BI (corresponding author), Caludon Ctr, Clifford Bridge Rd, Coventry CV2 2TE, W Midlands, England.
EM b.perry.1@warwick.ac.uk
RI Khandaker, Gulam/G-6171-2019; Upthegrove, Rachel/AAD-9761-2022; Marwaha,
   Steven/G-4489-2013; Thompson, Andrew/F-3153-2012
OI Upthegrove, Rachel/0000-0001-8204-5103; Perry, Benjamin
   I./0000-0002-1533-026X; Marwaha, Steven/0000-0002-0303-9942; Thompson,
   Andrew/0000-0002-0567-6013; Zammit, Stanley/0000-0002-2647-9211;
   Khandaker, Golam/0000-0002-4935-9220
FU National Institute for Health Research; Wellcome Trust [201486/Z/16/Z,
   102215/2/13/2]; Academy of Medical Sciences, UK [80354]; NIHR Bristol
   Biomedical Research Centre; Coventry and Warwickshire Partnership NHS
   Trust R&I Department, from the "Research Development Fund"; UK Medical
   Research Council [102215/2/13/2]; MRC [MC_PC_19009] Funding Source:
   UKRI; Wellcome Trust [201486/Z/16/Z] Funding Source: Wellcome Trust
FX B.I.P. is supported by an Academic Clinical Fellowship from the National
   Institute for Health Research. G.M.K. is supported by an Intermediate
   Clinical Fellowship from the Wellcome Trust (201486/Z/16/Z) and a
   Clinical Lecturer Starter Grant from the Academy of Medical Sciences, UK
   (80354). S.Z. is supported by the NIHR Bristol Biomedical Research
   Centre. Funding for data access was obtained from Coventry and
   Warwickshire Partnership NHS Trust R&I Department, from the "Research
   Development Fund." The UK Medical Research Council and Wellcome Trust
   (102215/2/13/2) and the University of Bristol provide core support for
   ALSPAC.
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NR 47
TC 35
Z9 36
U1 0
U2 3
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0586-7614
EI 1745-1701
J9 SCHIZOPHRENIA BULL
JI Schizophr. Bull.
PD MAR
PY 2019
VL 45
IS 2
BP 330
EP 338
DI 10.1093/schbul/sby040
PG 9
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA HO7XM
UT WOS:000461163300012
PM 29635418
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Lin, Q
   Huang, WQ
   Tzeng, CM
AF Lin, Qing
   Huang, Wen-Qing
   Tzeng, Chi-Meng
TI Genetic associations of leukoaraiosis indicate pathophysiological
   mechanisms in white matter lesions etiology
SO REVIEWS IN THE NEUROSCIENCES
LA English
DT Article
DE demyelination; genetics; neuroimaging; white matter lesions
ID SMALL-VESSEL DISEASE; GENOME-WIDE ASSOCIATION; HYPERINTENSITY VOLUME;
   SIGNAL HYPERINTENSITIES; ELDERLY-PEOPLE; BLOOD-PRESSURE; RISK-FACTORS;
   MULTIPLE-SCLEROSIS; METABOLIC SYNDROME; BRAIN
AB Leukoaraiosis (LA), also called white matter lesions (WMLs) and white matter hyperintensities (WMHs), is a frequent neuroimaging finding commonly seen on magnetic resonance imaging brain scans of elderly people with prevalence ranging from 50% to 100%. Although it remains asymptomatic, LA is not considered to be benign, and it is showed to be related to a host of poor clinical outcomes and increases the risk of disability, dementia, depression, stroke, and the overall morbidity and mortality. Pathologically, LA is characterized by loss of myelin and axons, patchy demyelination, and denudation of ependyma in regions of WMH. Age and hypertension are the most importantly established risk factors for LA. However, the precise pathogenic mechanisms remain unclear. Together with the previous findings, our recent genetic results strongly supported that LA is associated with immune response and neuroinflammation. Therefore, we confidently hypothesized that LA was not only a common neuroimaging phenomenon in the elderly but also an emerging neuroinflammatory disorder in the central nervous system. This article focusing on neuroimaging classification, genetics basis, and putative molecular mechanism introduced the basic knowledge and current status of LA and put forward some of our research ideas and results from our molecular genetics research, which may pave the way for deciphering the putative pathogenic mechanism, risk factor, epigenetic index, and its application in diagnostic agents or drug target for prevention and treatment. Thus, it could provide clinicians and researchers with a specific and modern overview of LA to enable the understanding of recent progress and future directions in this illness.
C1 [Lin, Qing; Huang, Wen-Qing; Tzeng, Chi-Meng] Xiamen Univ, Sch Pharmaceut Sci, TMRC, Xiamen 361102, Fujian, Peoples R China.
   [Lin, Qing] Xiamen Univ, Dept Neurol, Affiliated Hosp 1, Xiamen 361003, Fujian, Peoples R China.
C3 Xiamen University; Xiamen University
RP Tzeng, CM (corresponding author), Xiamen Univ, Sch Pharmaceut Sci, TMRC, Xiamen 361102, Fujian, Peoples R China.
EM cmtzeng@xmu.edu.cn
FU Fujian Provincial Science and Technology [2012Y0064]; Xiamen Science and
   Technology Bureau [350Z20121153]; National Natural Science Foundation of
   China [81272445, 81101331]
FX This study was approved by the Xiamen Ethical Committee and supported by
   the Fujian Provincial Science and Technology (grant no. 2012Y0064), the
   Xiamen Science and Technology Bureau (grant no. 350Z20121153), and the
   National Natural Science Foundation of China (grant nos. 81272445 and
   81101331).
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   Yoon HS, 2010, HAEMATOL-HEMATOL J, V95, P622, DOI 10.3324/haematol.2009.016949
NR 130
TC 22
Z9 26
U1 0
U2 21
PU WALTER DE GRUYTER GMBH
PI BERLIN
PA GENTHINER STRASSE 13, D-10785 BERLIN, GERMANY
SN 0334-1763
EI 1607-8470
J9 REV NEUROSCIENCE
JI Rev. Neurosci.
PD JUN
PY 2015
VL 26
IS 3
BP 343
EP 358
DI 10.1515/revneuro-2014-0082
PG 16
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA CI4NA
UT WOS:000354725400007
PM 25781674
DA 2025-06-11
ER

PT J
AU Lin, IH
   Lee, CY
   Chen, JT
   Chen, YH
   Chung, CH
   Sun, CA
   Chien, WC
   Chen, HC
   Chen, CL
AF Lin, I-Hung
   Lee, Chia-Yi
   Chen, Jiann-Torng
   Chen, Yi-Hao
   Chung, Chi-Hsiang
   Sun, Chien-An
   Chien, Wu-Chien
   Chen, Hung-Chi
   Chen, Ching-Long
TI Predisposing Factors for Severe Complications after Cataract Surgery: A
   Nationwide Population-Based Study
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Article
DE cataract surgery; nationwide population-based study; postoperative
   complication; systemic disease
ID RISK-FACTORS; RETINAL-DETACHMENT; DIABETES-MELLITUS; DYSFUNCTION;
   DEPRESSION; MANAGEMENT
AB We conducted a retrospective group study to evaluate the potential systemic risk factors for major postoperative complications of cataract surgery. Individuals diagnosed with (n = 2046) and without (n = 8184) serious complications after cataract surgery were matched 1:4 for age, sex, and index date obtained using Taiwan's National Health Insurance Research Database. The outcome was defined as at least one new inpatient or outpatient diagnosis of systemic disease one year before the index date. The effect of demographic data on postoperative complications was also analyzed in the multivariable model. Data were analyzed using univariate and multivariate conditional logistic regression models to calculate odds ratios (ORs) and 95% confidence intervals of the risk of developing serious complications. After the entire study interval, the major postoperative complications of cataract surgery were associated with the following systemic diseases: hypertension (adjusted OR (aOR) = 2.329, p < 0.001), diabetes mellitus (aOR = 2.818, p < 0.001), hyperlipidemia (aOR = 1.702, p < 0.001), congestive heart failure (aOR = 2.891, p < 0.001), rheumatic disease (aOR = 1.965, p < 0.001), and kidney disease needing hemodialysis (aOR = 2.942, p < 0.001). Additionally, demographic data including old age, higher urbanization level, higher level of care, and more frequent inpatient department visits were associated with a higher rate of postoperative complications. In conclusion, metabolic syndrome, chronic heart failure, end-stage renal disease, rheumatic disease, older age, and frequent inpatient department visits are correlated with the development of severe postoperative complications of cataract surgery. Therefore, cataract surgery patients should be informed about a higher possibility of postoperative complications.
C1 [Lin, I-Hung; Chen, Jiann-Torng; Chen, Yi-Hao; Chen, Ching-Long] Triserv Gen Hosp, Natl Def Med Ctr, Dept Ophthalmol, Taipei City 11490, Taiwan.
   [Lee, Chia-Yi] Show Chwan Mem Hosp, Dept Ophthalmol, Changhua 50093, Taiwan.
   [Chung, Chi-Hsiang; Chien, Wu-Chien] Triserv Gen Hosp, Natl Def Med Ctr, Dept Med Res, Taipei 11490, Taiwan.
   [Chung, Chi-Hsiang; Chien, Wu-Chien] Natl Def Med Ctr, Sch Publ Hlth, Taipei 11490, Taiwan.
   [Chung, Chi-Hsiang; Chien, Wu-Chien] Taiwanese Injury Prevent & Safety Promot Assoc, Taipei 11490, Taiwan.
   [Sun, Chien-An] Fu Jen Catholic Univ, Coll Med, Dept Publ Hlth, New Taipei 24205, Taiwan.
   [Sun, Chien-An] Fu Jen Catholic Univ, Coll Med, Big Data Res Ctr, New Taipei 24205, Taiwan.
   [Chien, Wu-Chien] Natl Def Med Ctr, Grad Inst Life Sci, Taipei 11490, Taiwan.
   [Chen, Hung-Chi] Chang Gung Mem Hosp, Dept Ophthalmol, Taoyuan 33305, Taiwan.
   [Chen, Hung-Chi] Chang Gung Univ, Coll Med, Dept Med, Taoyuan 33302, Taiwan.
   [Chen, Hung-Chi] Chang Gung Mem Hosp, Ctr Tissue Engn, Taoyuan 33305, Taiwan.
C3 Tri-Service General Hospital; National Defense Medical Center; Show
   Chwan Memorial Hospital; National Defense Medical Center; Tri-Service
   General Hospital; National Defense Medical Center; Fu Jen Catholic
   University; Fu Jen Catholic University; National Defense Medical Center;
   Chang Gung Memorial Hospital; Chang Gung University; Chang Gung Memorial
   Hospital
RP Chen, CL (corresponding author), Triserv Gen Hosp, Natl Def Med Ctr, Dept Ophthalmol, Taipei City 11490, Taiwan.; Chien, WC (corresponding author), Triserv Gen Hosp, Natl Def Med Ctr, Dept Med Res, Taipei 11490, Taiwan.; Chien, WC (corresponding author), Natl Def Med Ctr, Sch Publ Hlth, Taipei 11490, Taiwan.; Chien, WC (corresponding author), Taiwanese Injury Prevent & Safety Promot Assoc, Taipei 11490, Taiwan.; Chien, WC (corresponding author), Natl Def Med Ctr, Grad Inst Life Sci, Taipei 11490, Taiwan.; Chen, HC (corresponding author), Chang Gung Mem Hosp, Dept Ophthalmol, Taoyuan 33305, Taiwan.; Chen, HC (corresponding author), Chang Gung Univ, Coll Med, Dept Med, Taoyuan 33302, Taiwan.; Chen, HC (corresponding author), Chang Gung Mem Hosp, Ctr Tissue Engn, Taoyuan 33305, Taiwan.
EM petercard@gmail.com; ao6u.3msn@hotmail.com; jt66chen@gmail.com;
   doc30879@mail.ndmctsgh.edu.tw; g694810042@gmail.com;
   040866@mail.fju.edu.tw; chienwu@ndmctsgh.edu.tw; mr3756@cgmh.org.tw;
   doc30881@mail.ndmctsgh.edu.tw
RI Kuo, Shu-Chen/U-6115-2019; Wang, Binglong/GYQ-9382-2022
OI zhong Chung, qi xiang Chi-Hsiang/0000-0002-4576-9900; Chen,
   Hung-Chi/0000-0002-1117-7878; Lee, Chia-Yi/0000-0002-5719-0488; Chen,
   Ching-Long/0000-0002-4058-7753; Chien, Wu-Chien/0000-0002-3286-0780;
   Lin, I-Hung/0000-0003-4268-2540; Sun, Chien-An/0000-0001-9041-0537
FU Tri-Service General Hospital Research Foundation [TSGH-B-110012,
   TSGH-D-110109, TSGH-D-110112, TSGH-D-110173]
FX This study was supported by the Tri-Service General Hospital Research
   Foundation (TSGH-B-110012, TSGH-D-110109, TSGH-D-110112, and
   TSGH-D-110173), and the sponsor had no role in study design, data
   collection and analysis, decision to publish, or preparation of the
   manuscript.
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NR 48
TC 8
Z9 8
U1 0
U2 7
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD AUG
PY 2021
VL 10
IS 15
AR 3336
DI 10.3390/jcm10153336
PG 13
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA TW0EY
UT WOS:000682086100001
PM 34362122
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Jacob, L
   Kostev, K
   Smith, L
   Oh, H
   López-Sánchez, GF
   Shin, JI
   Abduljabbar, AS
   Haro, JM
   Koyanagi, A
AF Jacob, Louis
   Kostev, Karel
   Smith, Lee
   Oh, Hans
   Lopez-Sanchez, Guillermo F.
   Shin, Jae Il
   Abduljabbar, Adel S.
   Haro, Josep Maria
   Koyanagi, Ai
TI Sarcopenia and Mild Cognitive Impairment in Older Adults from Six Low-
   and Middle-Income Countries
SO JOURNAL OF ALZHEIMERS DISEASE
LA English
DT Article
DE Community-dwelling adults; low- and middle-income countries; mild
   cognitive impairment; multicountry study; sarcopenia
ID SKELETAL-MUSCLE MASS; C-REACTIVE PROTEIN; ALZHEIMERS-DISEASE; METABOLIC
   SYNDROME; ASSOCIATION; RISK; RECOMMENDATIONS; PREVALENCE; DEPRESSION;
   HEALTHY
AB Background: Little is known about the relationship between sarcopenia and mild cognitive impairment (MCI) in low- and middle-income countries (LMICs).
   Objective: This study aimed to investigate this association among community-dwelling adults aged >= 65 years from six LMICs.
   Methods: Cross-sectional, nationally representative data from the Study on Global Ageing and Adult Health (SAGE) were analyzed. These data were obtained in China, Ghana, India, Mexico, Russia, and South Africa in 2007-2010. Participants were considered to have sarcopenia if they had low skeletal muscle mass (i.e., lower skeletal mass index) and a weak handgrip strength. MCI was defined using the National Institute on Aging-Alzheimer's Association criteria. Multivariable logistic regression analysis was conducted to assess associations.
   Results: The final analytical sample consisted of 12,912 individuals aged >= 65 years with preservation in functional abilities without stroke (mean [standard deviation] age 72.2 [10.8] years; 45.2% males). The overall prevalence of sarcopenia and MCI were 11.3% and 18.1%, respectively. After adjusting for potential confounders, there was a positive association between sarcopenia and MCI in all countries (i.e., odds ratio [OR] > 1) with the exception of South Africa, and the overall estimate was OR = 1.60 (95% confidence interval [CI] = 1.32-1.93) with a low level of between-country heterogeneity (I-2= 0.0%).
   Conclusion: There was a positive association between sarcopenia and MCI in this sample of older adults living in LMICs. Causality should be assessed in future longitudinal research, while the utility of sarcopenia as a marker of MCI should also be investigated.
C1 [Jacob, Louis; Haro, Josep Maria; Koyanagi, Ai] Parc Sanitari St Joan de Deu, Res & Dev Unit, Barcelona, Spain.
   [Jacob, Louis; Haro, Josep Maria; Koyanagi, Ai] Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain.
   [Jacob, Louis] Univ Versailles St Quentin En Yvelines, Fac Med, Montigny Le Bretonneux, France.
   [Kostev, Karel] Philipps Univ Marburg, Marburg, Germany.
   [Smith, Lee] Anglia Ruskin Univ, Cambridge Ctr Sport & Exercise Sci, Cambridge, England.
   [Oh, Hans] Univ Southern Calif, Suzanne Dworak Peck Sch Social Work, Los Angeles, CA 90007 USA.
   [Lopez-Sanchez, Guillermo F.] Anglia Ruskin Univ, Sch Med, Vis & Eye Res Inst, Fac Hlth Educ Med & Social Care, Cambridge Campus, Cambridge, England.
   [Shin, Jae Il] Yonsei Univ, Dept Pediat, Coll Med, Seoul, South Korea.
   [Abduljabbar, Adel S.; Haro, Josep Maria] King Saud Univ, Riyadh, Saudi Arabia.
   [Koyanagi, Ai] ICREA, Barcelona, Spain.
C3 CIBER - Centro de Investigacion Biomedica en Red; CIBERSAM; Universite
   Paris Saclay; Philipps University Marburg; Anglia Ruskin University;
   University of Southern California; University of Cambridge; Anglia
   Ruskin University; Yonsei University; Yonsei University Health System;
   King Saud University; ICREA
RP Jacob, L (corresponding author), CIBERSAM, Parc Sanitari St Joan de Deu, Res & Dev Unit, Dr Antoni Pujadas 42, Barcelona 08830, Spain.
EM louis.jacob.contacts@gmail.com
RI ABDULJABBAR, ADEL/O-1933-2019; Haro, Josep Maria/D-1423-2011; Jacob,
   Louis/AAL-3956-2020; Smith, Lee/JPA-1418-2023; Kostev,
   Karel/S-4755-2019; SHIN, JAE IL/J-6922-2017; Lopez Sanchez, Guillermo
   Felipe/K-8703-2015
OI Smith, Lee/0000-0002-5340-9833; Kostev, Karel/0000-0002-2124-7227; SHIN,
   JAE IL/0000-0003-2326-1820; Oh, Hans/0000-0002-8458-8723; Lopez Sanchez,
   Guillermo Felipe/0000-0002-9897-5273
FU U.S. National Institute on Aging [OGHA 04034785, YA1323-08-CN-0020,
   Y1-AG-1005-01, R01-AG034479, R21-AG034263]
FX This paper uses data from WHO's Study on Global Ageing and Adult Health
   (SAGE). SAGE is supported by the U.S. National Institute on Aging
   through Interagency Agreements OGHA 04034785, YA1323-08-CN-0020,
   Y1-AG-1005-01 and through research grants R01-AG034479 and R21-AG034263.
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NR 56
TC 22
Z9 24
U1 0
U2 12
PU IOS PRESS
PI AMSTERDAM
PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS
SN 1387-2877
EI 1875-8908
J9 J ALZHEIMERS DIS
JI J. Alzheimers Dis.
PY 2021
VL 82
IS 4
BP 1745
EP 1754
DI 10.3233/JAD-210321
PG 10
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology
GA UD2OS
UT WOS:000687052500027
PM 34219725
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Rezaee, ME
   Ward, CE
   Pollock, M
   Shetty, SD
AF Rezaee, Michael E.
   Ward, Charlotte E.
   Pollock, Martha
   Shetty, Sugandh D.
TI Association between multiple chronic conditions and urolithiasis
SO INTERNATIONAL UROLOGY AND NEPHROLOGY
LA English
DT Article
DE Nephrolithiasis; Urolithiasis; Multimorbidity; Multiple chronic
   conditions; Utilization; Multimorbidity
ID KIDNEY-STONES; METABOLIC SYNDROME; CHRONIC DISEASES; CARE; HEALTH;
   NEPHROLITHIASIS; HYPERTENSION; DEPRESSION; QUALITY; IMPACT
AB Given the risk factors for stone disease, it is possible that multiple chronic condition (MCC) patients are at increased risk of developing new, recurrent, or worsening urolithiasis. The purpose of our investigation was to evaluate the relationship between MCCs and urolithiasis.
   Retrospective cohort using outpatient claims data for all adult members (18 years) of the Beaumont Employee Health Plan who received outpatient care between 2008 and 2013. Multiple logistic regression adjusted for age, sex, obesity, hyperlipidemia, hypertension, and diabetes was used to assess the relationship between number of comorbid chronic conditions and urolithiasis.
   The cohort consisted of 34,173 adult patients with an average age of 40.4 years and 61.2% being female. The prevalence of urolithiasis was 3.1% (n = 1059). Patients with urolithiasis had a significantly higher average number of comorbid chronic conditions (2.4 vs. 1.3, p < 0.001) than patient without urolithiasis. Both crude (OR 1.34; 95% CI 1.30-1.38) and adjusted logistic regression models (OR 1.37; 95% CI 1.31-1.44) revealed a significant relationship between number of comorbid chronic conditions and urolithiasis. More than 81% of patients had one or more co-occurring chronic conditions; the most common MCC combinations associated with urolithiasis were hypertension-hyperlipidemia, chronic back pain, and hyperlipidemia.
   We report an association between MCCs and urolithiasis. Future research is needed to better understand the temporality and strength of this relationship. Physicians should recognize that urolithiasis and MCCs are closely related and therefore may consider more aggressive primary prevention of chronic disease and improved management of MCCs.
C1 [Rezaee, Michael E.; Pollock, Martha; Shetty, Sugandh D.] Oakland Univ, William Beaumont Sch Med, 216 ODowd Hall,2200 N Squirrel, Rochester, MI 48309 USA.
   [Ward, Charlotte E.] Northwestern Univ, Ctr Healthcare Studies, Feinberg Sch Med, 633 N St Clair St,18th Floor, Chicago, IL 60611 USA.
   [Ward, Charlotte E.] Univ Chicago, Ctr Hlth Stat, 5801 South Ellis Ave, Chicago, IL 60637 USA.
   [Pollock, Martha] William Beaumont Hosp, Dept Internal Med, Beaumont Hlth, 1949 12 Mile Rd,Suite 100, Berkley, MI 48072 USA.
   [Shetty, Sugandh D.] Oakland Univ, William Beaumont Hosp, Dept Urol, William Beaumont Sch Med,Beaumont Hlth, 3601 W 13 Mile Rd, Royal Oak, MI 48073 USA.
C3 Oakland University; Northwestern University; Feinberg School of
   Medicine; University of Chicago; Beaumont Health; Oakland University;
   Beaumont Health; Corewell Health William Beaumont University Hospital
RP Rezaee, ME (corresponding author), Oakland Univ, William Beaumont Sch Med, 216 ODowd Hall,2200 N Squirrel, Rochester, MI 48309 USA.
EM merezaee@oakland.edu; Charlotte.Ward@northwestern.edu;
   Martha.Pollock@beaumont.edu; Sshetty@beaumont.edu
FU training Grant [T32 HS000084]; Agency of Healthcare Research and Quality
FX C. E. Ward is supported by the training Grant T32 HS000084 awarded to
   Northwestern University and the University of Chicago, by the Agency of
   Healthcare Research and Quality. The other authors do not have any
   support/financial disclosures.
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NR 30
TC 13
Z9 13
U1 0
U2 3
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0301-1623
EI 1573-2584
J9 INT UROL NEPHROL
JI Int. Urol. Nephrol.
PD AUG
PY 2017
VL 49
IS 8
BP 1361
EP 1367
DI 10.1007/s11255-017-1611-1
PG 7
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Urology & Nephrology
GA FB5RI
UT WOS:000406199200008
PM 28477302
DA 2025-06-11
ER

PT J
AU Wakabayashi, C
   Numakawa, T
   Ooshima, Y
   Hattori, K
   Kunugi, H
AF Wakabayashi, Chisato
   Numakawa, Tadahiro
   Ooshima, Yoshiko
   Hattori, Kotaro
   Kunugi, Hiroshi
TI Possible role of the dopamine D1 receptor in the sensorimotor
   gating deficits induced by high-fat diet
SO PSYCHOPHARMACOLOGY
LA English
DT Article
DE High-fat diet; Prepulse inhibition; Dopamine D-1 receptor; Dopamine D-2
   receptor; Monoamine; Cortex
ID PREPULSE INHIBITION; METABOLIC SYNDROME; ANIMAL-MODEL; SCHIZOPHRENIA;
   MICE; DEPRESSION; OBESITY; STARTLE; MEMORY; RATS
AB High-fat diet (HFD) has been recently reported to induce sensorimotor gating deficits, but the underlying mechanisms are not well understood.
   The purpose of this study is to determine whether HFD induces long-lasting deficits in sensorimotor gating and to examine the involvement of altered dopamine (DA) function.
   C57BL/6J mice were fed HFD for 10 weeks and then normal diet (ND) for 4 weeks. DA D-2 receptor (D2R) knockout (KO) mice were also fed HFD for 10 weeks. The mice were evaluated for prepulse inhibition (PPI) of acoustic startle after HFD and the subsequent 4-week ND. We evaluated the effect of SCH23390, a D-1 receptor (D1R) antagonist, on PPI and measured protein expression levels of D1R and D2R in the prefrontal cortex (PFC) in HFD mice. The concentrations of monoamines and their metabolites in the cortices of 10-week HFD or ND mice were measured using high performance liquid chromatography.
   Long-term HFD-induced PPI disruption in WT and D2R KO mice. Even after 4 weeks of subsequent ND, PPI remained to be disrupted. SCH23390 mitigated the PPI disruption. In HFD animals, D1R protein expression in the PFC was significantly decreased, while DA, homovanillic acid, and 3,4-dihydroxyphenylacetic acid levels in the cortex were increased.
   This is the first evidence that HFD can induce long-lasting deficits in sensorimotor gating through alteration of cortical levels of DA and its metabolites. Our data suggest that HFD-induced PPI deficits are related to altered D1R signaling and that D1R antagonists may have therapeutic effects on the deficits.
C1 [Wakabayashi, Chisato; Numakawa, Tadahiro; Ooshima, Yoshiko; Hattori, Kotaro; Kunugi, Hiroshi] Natl Ctr Neurol & Psychiat, Natl Inst Neurosci, Dept Mental Disorder Res, Kodaira, Tokyo 1878502, Japan.
C3 National Center for Neurology & Psychiatry - Japan
RP Kunugi, H (corresponding author), Natl Ctr Neurol & Psychiat, Natl Inst Neurosci, Dept Mental Disorder Res, 4-1-1 Ogawa Higashi, Kodaira, Tokyo 1878502, Japan.
EM hkunugi@ncnp.go.jp
RI Kunugi, Hiroshi/ABC-5260-2021
OI Kunugi, Hiroshi/0000-0002-7209-3790
FU Intramural Research Grant for Neurological and Psychiatric Disorders of
   NCNP; Health and Labour Sciences Research Grants; Strategic Research
   Program for Brain Sciences by the Ministry of Education, Culture,
   Sports, Science and Technology of Japan
FX This study was supported by the Intramural Research Grant for
   Neurological and Psychiatric Disorders of NCNP, Health and Labour
   Sciences Research Grants, and the Strategic Research Program for Brain
   Sciences by the Ministry of Education, Culture, Sports, Science and
   Technology of Japan. We thank Mr. K. Yamamoto for technical assistance.
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NR 30
TC 16
Z9 16
U1 0
U2 5
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0033-3158
EI 1432-2072
J9 PSYCHOPHARMACOLOGY
JI Psychopharmacology
PD DEC
PY 2015
VL 232
IS 24
BP 4393
EP 4400
DI 10.1007/s00213-015-4068-x
PG 8
WC Neurosciences; Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA CW7NS
UT WOS:000365186600001
PM 26359228
DA 2025-06-11
ER

PT J
AU Heggelund, J
   Nilsberg, GE
   Hoff, J
   Morken, G
   Helgerud, J
AF Heggelund, Jorn
   Nilsberg, Geir E.
   Hoff, Jan
   Morken, Gunnar
   Helgerud, Jan
TI Effects of high aerobic intensity training in patients with
   schizophrenia-A controlled trial
SO NORDIC JOURNAL OF PSYCHIATRY
LA English
DT Article
DE Cardiovascular disease; Exercise; Oxygen consumption; Schizophrenia
ID MENTALLY DISORDERED PATIENTS; CARDIOVASCULAR-DISEASE; METABOLIC
   SYNDROME; PHYSICAL EXERCISE; RISK; METAANALYSIS; CAPACITY;
   CHLORPROMAZINE; SUPERIOR; FITNESS
AB Background: Patients with schizophrenia have a high risk of cardiovascular disease (CVD). High aerobic intensity training (HIT) improve peak oxygen uptake (VO2peak), net mechanical efficiency of walking and risk factors for CVD but has not been investigated in patients with schizophrenia. Aims: To investigate effects from HIT on VO2peak, net mechanical efficiency of walking and risk factors for CVD in patients with schizophrenia. Methods: 25 inpatients (F20-29, ICD-10) were allocated to either HIT or playing computer games (CG), 3 days per week for 8 weeks. HIT consisted of 4 X 4-min intervals with 3-min break periods, at 85-95% and 70% of peak heart rate, respectively. Results: 12 and seven patients completed HIT and CG, respectively. The baseline VO2peak in both groups combined (n = 19) was 36.8 +/- 8.2 ml/kg/min and 3.12 +/- 0.55 l/min. The HIT group improved VO2peak by 12% from 3.17 +/- 0.59 to 3.56 +/- 0.68 l/min (P < 0.001), more than the CG group (P = 0.014). Net mechanical efficiency of walking improved by 12% in the HIT group from 19.8 +/- 3.0% to 22.2 +/- 4.5% (P = 0.005), more than the CG group (P = 0.031). The psychiatric symptoms, expressed as the Positive and Negative Syndrome Scale (PANSS) and the Calgary Depression Scale for Schizophrenia (CDSS), did not improve in either group. Conclusions: VO2peak and net mechanical efficiency of walking improved significantly by 8 weeks of HIT. HIT should be included in rehabilitation in order to improve physical capacity and contribute risk reduction of CVD.
C1 [Heggelund, Jorn] St Olavs Univ Hosp, Div Psychiat, Dept Res & Dev AFFU, N-7441 Trondheim, Norway.
   [Heggelund, Jorn; Morken, Gunnar] Norwegian Univ Sci & Technol, Fac Med, Dept Neurosci, N-7034 Trondheim, Norway.
   [Heggelund, Jorn; Nilsberg, Geir E.; Morken, Gunnar] St Olavs Univ Hosp, Div Psychiat, Dept Ostmarka, N-7441 Trondheim, Norway.
   [Hoff, Jan] St Olavs Univ Hosp, Dept Phys Med & Rehabil, N-7441 Trondheim, Norway.
   [Hoff, Jan; Helgerud, Jan] Norwegian Univ Sci & Technol, Fac Med, Dept Circulat & Med Imaging, N-7034 Trondheim, Norway.
   [Helgerud, Jan] Telemark Univ Coll, Dept Sports & Outdoor Life Studies, Bo, Norway.
   [Helgerud, Jan] Hokksund Med Rehabil Ctr, Hokksund, Norway.
C3 Norwegian University of Science & Technology (NTNU); Norwegian
   University of Science & Technology (NTNU); Norwegian University of
   Science & Technology (NTNU); Norwegian University of Science &
   Technology (NTNU); Norwegian University of Science & Technology (NTNU);
   University of South-Eastern Norway
RP Heggelund, J (corresponding author), St Olavs Univ Hosp, Div Psychiat, Dept Res & Dev AFFU, Box 3008 Lade, N-7441 Trondheim, Norway.
EM Jorn.Heggelund@ntnu.no
RI Morken, Gunnar/AAX-3373-2020
OI Morken, Gunnar/0000-0003-1972-5901
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NR 34
TC 101
Z9 115
U1 0
U2 27
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0803-9488
EI 1502-4725
J9 NORD J PSYCHIAT
JI Nord. J. Psychiatr.
PD SEP
PY 2011
VL 65
IS 4
BP 269
EP 275
DI 10.3109/08039488.2011.560278
PG 7
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 803RM
UT WOS:000293598400007
PM 21332297
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Singh, S
   Verma, V
   Abhinav
AF Singh, Shefali
   Verma, Vandana
   Abhinav
TI A systematic review on efficacy of Virechan karma on Psoriasis w.s.r to
   Ek-kustha
SO INTERNATIONAL JOURNAL OF AYURVEDIC MEDICINE
LA English
DT Review
DE Ek-kustha; Kustha; Psoriasis; Panchkarma; Virechan karma; Virechan with
   Shaman Chikitsa
AB Background of the study: The reported prevalence of Psoriasis in countries ranges between 0.09% and 11.43%, making Psoriasis a serious global problem with at least 100 million individuals affected worldwide. It is far more than 'just a skin disease' it has an unpredictable course of symptoms, a number of external triggers and significant co-morbidities, including arthritis, cardiovascular diseases, metabolic syndrome, inflammatory bowel disease and depression. Inspite of having recent development in modern medicine there is no specific medication for cure of Psoriasis it can be managed but not cured. Panchkarma (pentad therapy) and Shaman Chikitsa (pacification therapy) in Ayurveda may fill the gaps that exist regarding treatment. This systematic review analyses the role of Virechan karma (medicated purgation therapy) in the management of Psoriasis based on outcome of published research. Objective: Effectiveness of Virechan karma in management of Psoriasis. Method: Published research data were obtained from different E-databases eg. Pubmed, Google scholar, Research gate, Scopus, Web of science. The inclusion criteria of the selection of papers includes the studies conducted on the symptoms of Ek kustha, PASI scoring, standard protocol followed for Virechan Karma and the papers were excluded from the study which included only Nitya Virechan karma, only Shnehan karma(oleation therapy), other Panchkarma(pentad therapy) modality like Basti(medicated Enema) etc. Result and Conclusion: The maximum incidence of Psoriasis disease was found in subjects belonging to 30-40 year age group having Vata-Pitta dominant Sharirik Prakriti(somatic constituent) and Rajsika Mansika Prakriti(Psychic constituent). Virechan karma with Shaman Chikitsa showed significant improvement in Psoriasis patients than Vaman karma (medicated emesis) & Virechan karma.
C1 [Singh, Shefali; Verma, Vandana] BHU, IMS, Fac Ayurveda, Dept Kriya Sharir, Varanasi 221005, Uttar Pradesh, India.
   [Abhinav] BHU, IMS, Fac Ayurveda, Dept Panchkarma, Varanasi, Uttar Pradesh, India.
C3 Banaras Hindu University (BHU); Banaras Hindu University (BHU)
RP Verma, V (corresponding author), BHU, IMS, Fac Ayurveda, Dept Kriya Sharir, Varanasi 221005, Uttar Pradesh, India.
EM vandana04@bhu.ac.in
RI RAGHUNATH, VANDANA/AAO-3698-2021
FU Department of Kriya Sharir; IMS, library BHU, Varanasi
FX I would like to thank Department of Kriya Sharir and IMS, library BHU,
   Varanasi for their support in this article.
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   Sirunyan AM, 2018, J HIGH ENERGY PHYS, DOI 10.1007/JHEP11(2018)018
   Sirunyan A. M., 2018, Journal of High Energy Physics, V2018, DOI 10.1007/JHEP08(2018)016
NR 22
TC 0
Z9 0
U1 0
U2 1
PU AYURVEDA SAHITI PRABHA
PI ANDHRA PRADESH
PA 1-2-288-23, SBH COLONY, HYDERABAD, ANDHRA PRADESH, 500 029, INDIA
SN 0976-5921
J9 INT J AYURVEDIC MED
JI Int. J. Ayurvedic Med.
PD APR-JUN
PY 2022
VL 13
IS 2
BP 289
EP 295
PG 7
WC Medicine, Research & Experimental
WE Emerging Sources Citation Index (ESCI)
SC Research & Experimental Medicine
GA 3C3PP
UT WOS:000828538800004
DA 2025-06-11
ER

PT J
AU McGurk, SR
   Otto, MW
   Fulford, D
   Cutler, Z
   Mulcahy, LP
   Talluri, SS
   Qiu, WQ
   Gan, QN
   Tran, I
   Turner, L
   DeTore, NR
   Zawacki, SA
   Khare, C
   Pillai, A
   Mueser, KT
AF McGurk, Susan R.
   Otto, Michael W.
   Fulford, Daniel
   Cutler, Zachary
   Mulcahy, Leonard P.
   Talluri, Sai Snigdha
   Qiu, Wei Qiao
   Gan, Qini
   Tran, Ivy
   Turner, Laura
   DeTore, Nicole R.
   Zawacki, Stacey A.
   Khare, Chitra
   Pillai, Anilkumar
   Mueser, Kim T.
TI A randomized controlled trial of exercise on augmenting the effects of
   cognitive remediation in persons with severe mental illness
SO JOURNAL OF PSYCHIATRIC RESEARCH
LA English
DT Article
DE Severe mental illness; Exercise; Cognitive remediation; Schizophrenia;
   BDNF; Cognition
ID NEUROTROPHIC FACTOR; AEROBIC EXERCISE; SUPPORTED EMPLOYMENT; METABOLIC
   SYNDROME; BDNF LEVELS; SCHIZOPHRENIA; BRAIN; NEUROCOGNITION; DEPRESSION;
   METAANALYSIS
AB Background: Preliminary evidence suggests that aerobic exercise may augment the effects of cognitive remediation on improving cognitive functioning in severe mental illness. It has also been hypothesized that increases in cognitive functioning associated with adding exercise are mediated by increases in brain derived neurotrophic factor (BDNF). However, rigorous controlled trials are lacking.
   Methods: A randomized controlled trial was conducted to explore whether adding a 30-h aerobic exercise program over 10 weeks to an equally intensive cognitive remediation program (CR + E) improved cognitive functioning more than cognitive remediation alone (CR-Only). Thirty-four participants with schizophrenia or bipolar disorder were randomly assigned to CR + E or CR-Only, and cognitive functioning was assessed at baseline and post-treatment. Total and mature BDNF were measured in blood serum at baseline, Week-5 pre- and post-exercise, and Week-10 pre- and post-exercise.
   Results: Participants in both conditions had high levels of engagement in the interventions and improved significantly in cognitive functioning, but did not differ in amount of cognitive change. The groups also did not differ in changes in BDNF from pre-to post-exercise at Weeks 5 or 10, nor in resting BDNF levels. Exploratory analyses indicated that higher body mass index (BMI) significantly predicted attenuated improvement in cognitive functioning for both groups.
   Discussion: Exercise did not augment the effects of cognitive remediation in persons with severe mental illness, possibly because the cognitive remediation program resulted in strong gains in cognitive functioning. Moderate aerobic exercise does not appear to reliably increase BDNF levels in persons with severe mental illness.
C1 [McGurk, Susan R.; Cutler, Zachary; Mulcahy, Leonard P.; Mueser, Kim T.] Boston Univ, Ctr Psychiat Rehabil, Boston, MA 02215 USA.
   [McGurk, Susan R.; Fulford, Daniel; Khare, Chitra; Mueser, Kim T.] Boston Univ, Dept Occupat Therapy & Psychol & Brain Sci, Boston, MA 02215 USA.
   [Otto, Michael W.] Boston Univ, Dept Psychol & Brain Sci, Boston, MA USA.
   [Talluri, Sai Snigdha] IIT, Dept Psychol, Chicago Hlth Dispar Program, Chicago, IL USA.
   [Qiu, Wei Qiao] Boston Univ, Dept Psychiat, Sch Med, Boston, MA USA.
   [Qiu, Wei Qiao; Gan, Qini] Boston Univ, Sch Med, Pharmacol & Expt Therapeut, Boston, MA USA.
   [Tran, Ivy] Hofstra Univ, Dept Psychol, Hempstead, NY 11550 USA.
   [Turner, Laura] Franciscan Childrens Hosp, Boston, MA USA.
   [DeTore, Nicole R.] Massachusetts Gen Hosp, Dept Psychiat, Boston, MA 02114 USA.
   [DeTore, Nicole R.] Harvard Med Sch, Dept Psychiat, Boston, MA USA.
   [Zawacki, Stacey A.] Boston Univ, Dept Hlth Sci, Boston, MA 02215 USA.
   [Pillai, Anilkumar] Augusta Univ, Med Coll Georgia, Dept Psychiat & Hlth Behav, Augusta, GA USA.
C3 Boston University; Boston University; Boston University; Illinois
   Institute of Technology; Boston University; Boston University; Hofstra
   University; Harvard University; Harvard University Medical Affiliates;
   Massachusetts General Hospital; Harvard University; Harvard Medical
   School; Boston University; University System of Georgia; Augusta
   University
RP Mueser, KT (corresponding author), Boston Univ, Ctr Psychiat Rehabil, Boston, MA 02215 USA.; Mueser, KT (corresponding author), Boston Univ, Dept Occupat Therapy & Psychol & Brain Sci, Boston, MA 02215 USA.
EM mueser@bu.edu
RI Hofmann, Stefan/B-8769-2014
OI Tran, Ivy/0000-0002-5781-5097; DeTore, Nicole/0000-0002-4714-1973
FU Gayle Berg Research Fund from Sargent College, Boston University
FX This study was supported by the Gayle Berg Research Fund from Sargent
   College, Boston University. Other than financial support, the Gayle Berg
   Research Fund had no role in the design or execution of the study or the
   decision to publish this manuscript.
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NR 64
TC 8
Z9 8
U1 3
U2 18
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-3956
EI 1879-1379
J9 J PSYCHIATR RES
JI J. Psychiatr. Res.
PD JUL
PY 2021
VL 139
BP 38
EP 46
DI 10.1016/j.jpsychires.2021.04.033
EA MAY 2021
PG 9
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA SO8MV
UT WOS:000659230100006
PM 34022474
DA 2025-06-11
ER

PT J
AU Alfraji, N
   Douedi, S
   Alshami, A
   Kuzyshyn, H
   Tang, XY
AF Alfraji, Nasam
   Douedi, Steven
   Alshami, Abbas
   Kuzyshyn, Halyna
   Tang, Xiaoyin
TI Nonischemic Dilated Cardiomyopathy in Untreated Long-Term Psoriatic
   Arthritis: A Newly Recognized Association: A Case Report with Mini
   Review
SO AMERICAN JOURNAL OF CASE REPORTS
LA English
DT Review
DE Arthritis, Psoriatic; Autoimmune Diseases; Cardiomyopathies; Psoriasis
AB Objective: Rare co-existance of disease or pathology
   Background: Psoriasis is a chronic inflammatory skin disease associated with multiple comorbidities including psoriatic ar-thritis (PsA), atherosclerotic disease, metabolic syndrome, diabetes, hypertension, obesity, and depression. Interestingly, nonischemic cardiomyopathy, especially dilated cardiomyopathy (DCM), has been associated with psoriasis and reported in only in a few cases in the literature.
   Case Report: We report the rare case of a 58-year-old man with a medical history of untreated severe psoriasis and PsA who presented with a sudden onset of shortness of breath. Laboratory and radiographic studies showed an elevat-ed level of B-type natriuretic peptide and acute bilateral pulmonary edema. The patient had normal coronary arteries on cardiac catheterization and echocardiography showed newly diagnosed DCM with systolic and di-astolic dysfunction. Cardiac magnetic resonance imaging was consistent with nonischemic DCM (NIDCM) with no evidence of hypertrophy, infiltrative process, or edema. The patient was diagnosed with acute congestive heart failure secondary to NIDCM in the setting of long-standing untreated psoriasis. He responded well to di-uretics, was placed on guideline-directed medical therapy, and was discharged with a LifeVest personal cardiac defibrillator. As an outpatient, the patient was started on secukinumab, a monoclonal antibody against inter-leukin-17A. At his last follow-up appointment, the patient reported improvement in his cardiac symptoms and resolution of his psoriatic skin lesions; repeat echocardiography showed improvement in his ejection fraction.
   Conclusions: Although studies have shown a higher prevalence of cardiovascular disease in patients with psoriasis, an asso-ciation with NIDCM has not been studied sufficiently. We recommend further studies of the prevalence, patho-
C1 [Alfraji, Nasam; Douedi, Steven; Alshami, Abbas] Jersey Shore Univ, Dept Med, Med Ctr, Hackensack Meridian Hlth, Neptune, NJ 07753 USA.
   [Kuzyshyn, Halyna; Tang, Xiaoyin] Jersey Shore Univ, Dept Rheumatol, Med Ctr, Hackensack Meridian Hlth, Neptune, NJ USA.
C3 Jersey Shore University Medical Center; Jersey Shore University Medical
   Center
RP Alfraji, N (corresponding author), Jersey Shore Univ, Dept Med, Med Ctr, Hackensack Meridian Hlth, Neptune, NJ 07753 USA.
EM nasam.alfraji@hmhn.org
RI Alshami, Abbas/AAR-6554-2020
CR Abdelaoui B, 2020, INT J ADV RES, V8, P596
   Boehncke S, 2011, J EUR ACAD DERMATOL, V25, P1187, DOI 10.1111/j.1468-3083.2010.03947.x
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NR 14
TC 3
Z9 4
U1 0
U2 1
PU INT SCIENTIFIC INFORMATION, INC
PI MELVILLE
PA 150 BROADHOLLOW RD, STE 114, MELVILLE, NY 11747 USA
EI 1941-5923
J9 AM J CASE REP
JI Am. J. Case Rep.
PD APR 2
PY 2021
VL 22
AR e930041
DI 10.12659/AJCR.930041
PG 5
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA RL9ZL
UT WOS:000639321800001
PM 33795630
OA Green Published
DA 2025-06-11
ER

PT J
AU Rubinstein, G
   Osswald, A
   Hoster, E
   Losa, M
   Elenkova, A
   Zacharieva, S
   Machado, MC
   Hanzu, FA
   Zopp, S
   Ritzel, K
   Riester, A
   Braun, LT
   Kreitschmann-Andermahr, I
   Storr, HL
   Bansal, P
   Barahona, MJ
   Cosaro, E
   Dogansen, SC
   Johnston, PC
   de Oliveira, RS
   Raftopoulos, C
   Scaroni, C
   Valassi, E
   van der Werff, SJA
   Schopohl, J
   Beuschlein, F
   Reincke, M
AF Rubinstein, German
   Osswald, Andrea
   Hoster, Eva
   Losa, Marco
   Elenkova, Atanaska
   Zacharieva, Sabina
   Machado, Marcio Carlos
   Hanzu, Felicia Alexandra
   Zopp, Stephanie
   Ritzel, Katrin
   Riester, Anna
   Braun, Leah Theresa
   Kreitschmann-Andermahr, Ilonka
   Storr, Helen L.
   Bansal, Prachi
   Barahona, Maria-Jose
   Cosaro, Elisa
   Dogansen, Sema Ciftci
   Johnston, Philip C.
   de Oliveira, Ricardo Santos
   Raftopoulos, Christian
   Scaroni, Carla
   Valassi, Elena
   van der Werff, Steven J. A.
   Schopohl, Jochen
   Beuschlein, Felix
   Reincke, Martin
TI Time to Diagnosis in Cushing's Syndrome: A Meta-Analysis Based on 5367
   Patients
SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Article
DE hypercortisolism; ACTH; cortisol; symptoms; meta-analysis
ID LONG-TERM REMISSION; TERTIARY CARE CENTER; PITUITARY SURGERY;
   TRANSSPHENOIDAL SURGERY; DISEASE; MORTALITY; EXPERIENCE; CHILDREN;
   RECOVERY; TUMORS
AB Context: Signs and symptoms of Cushing's syndrome (CS) overlap with common diseases, such as the metabolic syndrome, obesity, osteoporosis, and depression. Therefore, it can take years to finally diagnose CS, although early diagnosis is important for prevention of complications.
   Objective: The aim of this study was to assess the time span between first symptoms and diagnosis of CS in different populations to identify factors associated with an early diagnosis.
   Data Sources: A systematic literature search via PubMed was performed to identify studies reporting on time to diagnosis in CS. In addition, unpublished data from patients of our tertiary care center and 4 other centers were included.
   Study Selection: Clinical studies reporting on the time to diagnosis of CS were eligible. Corresponding authors were contacted to obtain additional information relevant to the research question.
   Data Extraction: Data were extracted from the text of the retrieved articles and from additional information provided by authors contacted successfully. From initially 3326 screened studies 44 were included.
   Data Synthesis: Mean time to diagnosis for patients with CS was 34 months (ectopic CS: 14 months; adrenal CS: 30 months; and pituitary CS: 38 months; P < .001). No difference was found for gender, age (<18 and >= 18 years), and year of diagnosis (before and after 2000). Patients with pituitary CS had a longer time to diagnosis in Germany than elsewhere.
   Conclusions: Time to diagnosis differs for subtypes of CS but not for gender and age. Time to diagnosis remains to be long and requires to be improved.
C1 [Rubinstein, German; Osswald, Andrea; Zopp, Stephanie; Ritzel, Katrin; Riester, Anna; Braun, Leah Theresa; Schopohl, Jochen; Beuschlein, Felix; Reincke, Martin] Klinikum Univ Munchen, Med Klin & Poliklin 4, Munich, Germany.
   [Hoster, Eva] Ludwig Maximilians Univ Munchen, Inst Med Informat Proc Biometry & Epidemiol, Munich, Germany.
   [Losa, Marco] Univ Vita Salute San Raffaele, IRCCS San Raffaele, Milan, Italy.
   [Elenkova, Atanaska; Zacharieva, Sabina] Med Univ Sofia, Acad Ivan Penchev, Dept Endocrinol, USHATE, Sofia, Bulgaria.
   [Machado, Marcio Carlos] Univ Sao Paulo, Med Sch, Div Endocrinol & Metab, Neuroendocrine Unit, Sao Paulo, SP, Brazil.
   [Machado, Marcio Carlos] AC Camargo Canc Ctr, Endocrinol Serv, Sao Paulo, SP, Brazil.
   [Hanzu, Felicia Alexandra] Univ Barcelona, Hosp Clin, Dept Endocrinol, IDIBAPS, Barcelona, Spain.
   [Kreitschmann-Andermahr, Ilonka] Univ Duisburg Essen, Univ Klinikum Essen, Neurochirurg Klin, Essen, Germany.
   [Storr, Helen L.] Queen Mary Univ London, Barts & London Sch Med & Dent, William Harvey Res Inst, Ctr Endocrinol, London EC1M 6BQ, England.
   [Bansal, Prachi] Seth Gordhandas Sunderdas Med Coll, Dept Endocrinol, Mumbai, Maharashtra, India.
   [Bansal, Prachi] King Edward Mem Hosp, Bombay, Maharashtra, India.
   [Barahona, Maria-Jose] Hosp Univ Mutua Terrassa, Dept Endocrinol, Barcelona, Spain.
   [Cosaro, Elisa] Univ Verona, Sect Endocrinol, Dept Med, Verona, Italy.
   [Dogansen, Sema Ciftci] Istanbul Univ, Istanbul Fac Med, Dept Internal Med, Div Endocrinol & Metab, Istanbul, Turkey.
   [Johnston, Philip C.] Royal Victoria Hosp, Reg Ctr Endocrinol & Diabet, Belfast, Antrim, North Ireland.
   [de Oliveira, Ricardo Santos] Univ Sao Paulo, Univ Hosp Ribeirao Preto Med Sch, Div Pediat Neurosurg, Dept Surg & Anat, Ribeirao Preto, Brazil.
   [Raftopoulos, Christian] Catholic Univ Louvain, Univ Hosp St Luc, Dept Neurosurg, Brussels, Belgium.
   [Scaroni, Carla] Univ Hosp Padova, Dept Med DIMED, Endocrinol Unit, Padua, Italy.
   [Valassi, Elena] ISCIII, IIB St Pau, Unidad 747, CIBERER,Hosp St Pau,Endocrinol Med Dept, Barcelona, Spain.
   [van der Werff, Steven J. A.] Leiden Univ, Med Ctr, Dept Psychiat, Leiden, Netherlands.
   [Beuschlein, Felix] Univ Spital Zurich, Klin Endokrinol Diabetol & Klin Ernahrung, Zurich, Switzerland.
C3 University of Munich; University of Munich; Vita-Salute San Raffaele
   University; IRCCS Ospedale San Raffaele; Medical University Sofia;
   Universidade de Sao Paulo; A.C.Camargo Cancer Center; University of
   Barcelona; Hospital Clinic de Barcelona; IDIBAPS; University of Duisburg
   Essen; University of London; Queen Mary University London; Seth
   Gordhandas Sunderdas Medical College & King Edward Memorial Hospital;
   Seth Gordhandas Sunderdas Medical College & King Edward Memorial
   Hospital; Hospital Universitario Mutua Terrassa; University of Verona;
   Istanbul University; Universidade de Sao Paulo; Universite Catholique
   Louvain; Cliniques Universitaires Saint-Luc; University of Padua;
   Azienda Ospedaliera - Universita di Padova; Instituto de Salud Carlos
   III; CIBER - Centro de Investigacion Biomedica en Red; CIBERER; Leiden
   University - Excl LUMC; Leiden University; Leiden University Medical
   Center (LUMC); University of Zurich; University Zurich Hospital
RP Reincke, M (corresponding author), Ludwig Maximilians Univ Munchen, Klinikum Univ Munchen, Med Klin & Poliklin 4, Ziemssenstr 1, D-80336 Munich, Germany.
EM martin.reincke@med.uni-muenchen.de
RI bansal, prachi/GPW-9913-2022; Zacharieva, Sabina/GQO-9261-2022;
   Barahona, Maria José/ABE-9068-2021; Schopohl, Jochen/AAD-6184-2021;
   Beuschlein, Felix/N-1282-2018; Hoster, Eva/M-2795-2019; de Oliveira,
   Ricardo/AAW-7714-2020; Storr, Helen/JOZ-3519-2023; Valassi,
   Elena/KAZ-9712-2024; losa, marco/AAI-3569-2020; Elenkova,
   Atanaska/O-6029-2018; Santos de Oliveira, Ricardo/A-2039-2010
OI Hoster, Eva/0000-0002-0749-1389; Rubinstein, German/0000-0002-7260-0748;
   Barahona, Maria-Jose/0000-0003-2935-6521; Storr,
   Helen/0000-0002-9963-1931; Losa, Marco/0000-0001-7810-8247; Riester,
   Anna/0000-0003-3231-7435; Zacharieva, Sabina/0000-0001-6087-7136; Hanzu,
   Felicia Alexandra/0000-0002-2399-4023; Santos de Oliveira,
   Ricardo/0000-0003-0390-5553
FU Else Kroner-Fresenius Stiftung [2012_A103, 2015_A228]; Deutsche
   Forschungsgemeinschaft (DFG, German Research Foundation) [314061271-TRR
   205]
FX This work is part of the German Cushing's Registry CUSTODES and has been
   supported by a grant from the Else Kroner-Fresenius Stiftung to MR
   (2012_A103 and 2015_A228). Additionally, AR, FB, and MR received funding
   by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation)
   Projektnummer: 314061271-TRR 205.
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NR 62
TC 62
Z9 62
U1 0
U2 5
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0021-972X
EI 1945-7197
J9 J CLIN ENDOCR METAB
JI J. Clin. Endocrinol. Metab.
PD MAR
PY 2020
VL 105
IS 3
BP E12
EP E22
DI 10.1210/clinem/dgz136
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA LD2NL
UT WOS:000525870500003
PM 31665382
OA Bronze, Green Accepted, Green Submitted
DA 2025-06-11
ER

PT J
AU Henriksson, M
   Nyberg, J
   Schiöler, L
   Hensing, G
   Kuhn, GH
   Söderberg, M
   Torén, K
   Löve, J
   Waern, M
   Åberg, M
AF Henriksson, Malin
   Nyberg, Jenny
   Schioler, Linus
   Hensing, Gunnel
   Kuhn, Georg H.
   Soderberg, Mia
   Toren, Kjell
   Love, Jesper
   Waern, Margda
   Aberg, Maria
TI Cause-specific mortality in Swedish males diagnosed with non-psychotic
   mental disorders in late adolescence: a prospective population-based
   study
SO JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH
LA English
DT Article
DE depression; adolescents CG; alcohol; mortality; cohort studies
ID EXCESS MORTALITY; PSYCHIATRIC-INPATIENTS; CARDIOVASCULAR FITNESS;
   HOSPITAL ADMISSIONS; DEPRESSIVE DISORDER; METABOLIC SYNDROME; EARLY
   ADULTHOOD; RISK; COHORT; CONSCRIPTION
AB Background While risk of premature death is most pronounced among persons with severe mental illness, also milder conditions are associated with increased all-cause mortality. We examined non-psychotic mental (NPM) disorders and specific causes of natural death in a cohort of late adolescent men followed for up to 46 years.
   Methods Prospective cohort study of Swedish males (n=1 784 626) who took part in structured conscription interviews 1968-2005. 74 525 men were diagnosed with NPM disorders at or prior to conscription. Median follow-up time was 26 years. HRs for cause-specific mortality were calculated using Cox proportional hazards models.
   Results Risks in fully adjusted models were particularly elevated for death by infectious diseases (depressive and neurotic/adjustment disorders (HR 2.07; 95%CI 1.60 to 2.67), personality disorders (HR 2.90; 95%CI 1.96 to 4.28) and alcohol-related and other substance use disorders (HR 9.02; 95%CI 6.63 to 12.27)) as well as by gastrointestinal causes (depressive and neurotic/adjustment disorders (HR 1.64; 95%CI 1.42 to 1.89), personality disorders (HR 2.77; 95%CI 2.27 to 3.38) and alcohol-related/substance use disorders (HR 4.41; 95%CI 3.59 to 5.42)).
   Conclusion Young men diagnosed with NPM disorders had a long-term increased mortality risk, in particular due to infectious and gastrointestinal conditions. These findings highlight the importance of early preventive actions for adolescents with mental illness.
C1 [Henriksson, Malin; Aberg, Maria] Univ Gothenburg, Sahlgrenska Acad, Inst Med, Dept Publ Hlth & Community Med Primary Hlth Care, Gothenburg, Sweden.
   [Nyberg, Jenny; Kuhn, Georg H.] Univ Gothenburg, Inst Neurosci & Physiol, Ctr Brain Repair & Rehabil, Gothenburg, Sweden.
   [Schioler, Linus; Soderberg, Mia; Toren, Kjell] Univ Gothenburg, Occupat & Environm Med, Inst Med, Gothenburg, Sweden.
   [Hensing, Gunnel; Love, Jesper] Univ Gothenburg, Inst Med, Sect Social Med & Epidemiol, Gothenburg, Sweden.
   [Waern, Margda] Univ Gothenburg, Inst Neurosci & Physiol, Dept Psychiat & Neurochem, Neuropsychiat Epidemiol Unit, Gothenburg, Sweden.
C3 University of Gothenburg; University of Gothenburg; University of
   Gothenburg; University of Gothenburg; University of Gothenburg
RP Åberg, M (corresponding author), Univ Gothenburg, Dept Publ Hlth & Community Med Primary Hlth Care, Inst Med, SE-40530 Gothenburg, Sweden.
EM maria.aberg@gu.se; maria.aberg@gu.se
RI Nyberg, Jenny/AFS-7456-2022; Aberg, Maria/R-4001-2016; Kuhn,
   Hans-Georg/L-8127-2014
OI Aberg, Maria/0000-0002-0323-1061; Henriksson, Malin/0000-0003-4973-9191;
   Soderberg, Mia/0000-0003-0662-6541; Kuhn,
   Hans-Georg/0000-0003-4247-5613; Love, Jesper/0000-0003-3184-6730
FU Swedish government [ALFGBG-427301, ALFGBG-715841]; county councils
   concerning economic support of research and education of doctors
   [ALFGBG-427301, ALFGBG-715841]; Swedish Research Council [2013-2699,
   2013-5187, 20134236]; Swedish Council for Health, Working Life and
   Welfare (FORTE) [2007-2280, 2013-0325]; Stiftelsen Peter Erikssons
   minnesfond for hjarnforskning; Gothenburg Medical Society
FX This study was supported by grants from the Swedish state under an
   agreement between the Swedish government and the county councils
   concerning economic support of research and education of doctors
   (ALFGBG-427301, ALFGBG-715841) and the Swedish Research Council
   2013-2699, 2013-5187, 20134236 and the Swedish Council for Health,
   Working Life and Welfare (FORTE) (2007-2280, 2013-0325) and Stiftelsen
   Peter Erikssons minnesfond for hjarnforskning. Financial support was
   also provided by the Gothenburg Medical Society.
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NR 40
TC 6
Z9 7
U1 0
U2 4
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 0143-005X
EI 1470-2738
J9 J EPIDEMIOL COMMUN H
JI J. Epidemiol. Community Health
PD JUL
PY 2018
VL 72
IS 7
BP 582
EP 588
DI 10.1136/jech-2018-210461
PG 7
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA GN3NR
UT WOS:000438913200006
PM 29581226
DA 2025-06-11
ER

PT J
AU Helmick, CG
   Lee-Han, H
   Hirsch, SC
   Baird, TL
   Bartlett, CL
AF Helmick, Charles G.
   Lee-Han, Hyewon
   Hirsch, Shawn C.
   Baird, Tiffany L.
   Bartlett, Christopher L.
TI Prevalence of Psoriasis Among Adults in the US 2003-2006 and 2009-2010
   National Health and Nutrition Examination Surveys
SO AMERICAN JOURNAL OF PREVENTIVE MEDICINE
LA English
DT Article
ID QUALITY-OF-LIFE; ALCOHOL-CONSUMPTION; RISK-FACTORS; METABOLIC SYNDROME;
   CLINICAL SEVERITY; UNITED-STATES; ARTHRITIS; POPULATION; SMOKING;
   OBESITY
AB Background: A 2010 CDC-sponsored consultation of psoriasis, psoriatic arthritis, and public health experts developed a public health agenda for psoriasis and psoriatic arthritis indicating that additional population-based research is needed to better characterize psoriasis in the population.
   Purpose: To better characterize the burden of psoriasis in the U.S. using recent population-based, cross-sectional data in this 2012 analysis.
   Methods: A subset of 10,676 adults aged 20-59 years from the 2003-2006 and 2009-2010 National. Health and Nutrition Examination Surveys was used to examine psoriasis prevalence, severity, disparities, health-related quality of life, and selected comorbidities.
   Results: The overall prevalence of psoriasis was 3.1% (95% CI=2.6, 3.6); extrapolating to older adults suggests that 6.7 million adults aged >= 20 years are affected. Psoriasis was significantly more prevalent among non-Hispanic whites than other race/ethnicity subgroups, as well as among those with arthritis. Approximately 82% reported no/little or mild disease; the impact of psoriasis on daily life increased with disease severity (p=0.0001 for trend). Those with psoriasis reported significantly more frequent mental distress or mild to severe depression than those without psoriasis. Psoriasis was also significantly associated with obesity and former smoking status. Conclusions: Psoriasis is a large public health problem. Further characterizing psoriasis from a public-health perspective will require better survey questions and inclusion of these questions in national surveys. Published by Elsevier Inc. on behalf of American Journal of Preventive Medicine
C1 [Helmick, Charles G.] CDC, Atlanta, GA 30341 USA.
   [Baird, Tiffany L.] SciMetrika LLC, Atlanta, GA USA.
   [Lee-Han, Hyewon; Hirsch, Shawn C.; Bartlett, Christopher L.] SciMetrika LLC, Durham, NC USA.
C3 Centers for Disease Control & Prevention - USA
RP Helmick, CG (corresponding author), CDC, 4770 Buford Hwy,F78, Atlanta, GA 30341 USA.
EM chelmick@cdc.gov
OI Hirsch, Shawn/0000-0001-6280-9559
FU USDHHS; CDC [200-2008-27889]
FX We would like to thank the many academic and CDC colleagues who have
   provided expert consultation and technical advice during the conduct of
   this work. Specifically, we would like to acknowledge the technical
   advice of the NHANES staff at the National Center for Health Statistics
   in the CDC and the topical expertise provided by Drs. Joel M. Gelfand,
   MD, MSCE, M. Elaine Husni, MD, MPH, Abrar A. Qureshi, MD, MPH,
   Christopher Ritchlin, MD, MPH, and Jeffrey J. Sacks, MD, MPH. Their
   support and guidance is greatly appreciated. Funding was provided by the
   USDHHS, CDC (contract no. 200-2008-27889).
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NR 54
TC 153
Z9 164
U1 0
U2 26
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0749-3797
EI 1873-2607
J9 AM J PREV MED
JI Am. J. Prev. Med.
PD JUL
PY 2014
VL 47
IS 1
BP 37
EP 45
DI 10.1016/j.amepre.2014.02.012
PG 9
WC Public, Environmental & Occupational Health; Medicine, General &
   Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; General & Internal Medicine
GA AJ4PH
UT WOS:000337657800005
PM 24746373
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Corona, G
   Mannucci, E
   Petrone, L
   Ricca, V
   Balercia, G
   Mansani, R
   Chiarini, V
   Giommi, R
   Forti, G
   Maggi, M
AF Corona, G
   Mannucci, E
   Petrone, L
   Ricca, V
   Balercia, G
   Mansani, R
   Chiarini, V
   Giommi, R
   Forti, G
   Maggi, M
TI Association of hypogonadism and type II diabetes in men attending an
   outpatient erectile dysfunction clinic
SO INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH
LA English
DT Article
DE hypogonadism; diabetes mellitus; erectile dysfunction; SIEDY (c);
   Structured Interview
ID HORMONE-BINDING GLOBULIN; MIDDLE-AGED MEN; HYPOGONADOTROPIC
   HYPOGONADISM; INSULIN-RESISTANCE; METABOLIC SYNDROME; TESTOSTERONE GEL;
   MELLITUS; SILDENAFIL; EXPRESSION; DEPRESSION
AB Patients with diabetes mellitus (DM) were more often hypogonadal than normal fasting glucose subjects. The aim of this investigation is the assessment of characteristics and psychobiological correlates of DM associated with hypogonadism (DMAH). The Structured Interview SIEDY(C) was used along with several biochemical, psychological and instrumental investigations in a series of more than 1200 patients with erectile dysfunction (ED); 16% of whom with type II DM. Hypogonadism was defined as circulating total testosterone (T) below 10.4 nmol/l. The prevalence of hypogonadism was 24.5% in DM versus 12.6% in the rest of the sample (P < 0.0001); differences in the prevalence of hypogonadism retained significance after adjustment for age and BMI. DMAH was associated with typical hypogonadism-related symptoms, such as reduction in sexual desire, leading to a decreased number of sexual attempts, and with higher depressive symptomatology. In DMAH, testis size and LH concentrations were significantly reduced, suggesting a central origin of the disease. At penile Duplex ultrasound examination, diabetic patients and in particular hypogonadal type II diabetic patients showed lower levels of basal and dynamic (after PGE(1) injection) peak systolic velocity and acceleration, when compared to the rest of the sample, even after adjustment for age and BMI. Our results show that hypogonadism is frequently associated with type II DM, at least in the 6th decade. DMAH might exacerbate sexual dysfunction by reducing libido and mood and further compromising penile vascular reactivity.
C1 Univ Florence, Dept Clin Physiopathol, Androl Unit, I-50139 Florence, Italy.
   Univ Florence, Dept Crit Care, Geriatr Unit, Diabet Sect, Florence, Italy.
   Univ Florence, Dept Neurol & Psychiat Sci, Psychiat Unit, Florence, Italy.
   Polytech Univ Marche, Dept Internal Med, Endocrinol Unit, Ancona, Italy.
   Maggiore Bellaria Hosp, Endocrinol Unit, Bologna, Italy.
   Int Inst Sexol, Florence, Italy.
C3 University of Florence; University of Florence; University of Florence;
   Marche Polytechnic University; AUSL di Bologna
RP Univ Florence, Dept Clin Physiopathol, Androl Unit, Viale Pieraccini 6, I-50139 Florence, Italy.
EM m.maggi@dfc.unifi.it
RI Maggi, Mario/AAB-8284-2019; Petrone, Luisa/L-1805-2018; ricca,
   valdo/K-8382-2012; Mannucci, Edoardo/K-6749-2016
OI ricca, valdo/0000-0002-9291-2124; MAGGI, Mario/0000-0003-3267-4221;
   Mannucci, Edoardo/0000-0001-9759-9408
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NR 42
TC 137
Z9 145
U1 0
U2 2
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0955-9930
EI 1476-5489
J9 INT J IMPOT RES
JI Int. J. Impot. Res.
PD MAR-APR
PY 2006
VL 18
IS 2
BP 190
EP 197
DI 10.1038/sj.ijir.3901391
PG 8
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 028EB
UT WOS:000236468600014
PM 16136189
DA 2025-06-11
ER

PT J
AU Ahti, J
   Kieseppae, T
   Haaki, W
   Suvisaari, J
   Niemelae, S
   Suokas, K
   Holm, M
   Wegelius, A
   Kampman, O
   Laehteenvuo, M
   Paunio, T
   Tiihonen, J
   Hietala, J
   Isometsae, E
AF Ahti, Johan
   Kieseppae, Tuula
   Haaki, Willehard
   Suvisaari, Jaana
   Niemelae, Solja
   Suokas, Kimmo
   Holm, Minna
   Wegelius, Asko
   Kampman, Olli
   Laehteenvuo, Markku
   Paunio, Tiina
   Tiihonen, Jari
   Hietala, Jarmo
   Isometsae, Erkki
TI General medical comorbidities in psychotic disorders in the Finnish
   SUPER study
SO SCHIZOPHRENIA
LA English
DT Article
ID SEVERE MENTAL-ILLNESS; BIPOLAR I DISORDER; BODY-MASS INDEX;
   CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; RELATIVE RISK;
   SCHIZOPHRENIA; MORTALITY; METAANALYSIS; SMOKING
AB Schizophrenia (SZ), schizoaffective disorder (SZA), bipolar disorder (BD), and psychotic depression (PD) are associated with premature death due to preventable general medical comorbidities (GMCs). The interaction between psychosis, risk factors, and GMCs is complex and should be elucidated. More research particularly among those with SZA or PD is warranted. We evaluated the association between registry-based psychotic disorders and GMC diagnoses in a large national sample of participants with different psychotic disorders. In addition, we examined whether body mass index (BMI) and smoking as risk factors for GMCs explain differences between diagnostic groups. This was a cross-sectional study of a clinical population of participants (n = 10,417) in the Finnish SUPER study. Registry-based diagnoses of psychotic disorders and hypertension, diabetes, chronic obstructive pulmonary disease (COPD), cancers, ischemic heart disease, and liver disorders were obtained. Participants' BMI and self-reported smoking were recorded. Total effect of diagnostic category adjusted for age and sex as well as direct effect including known risk factors was calculated using logistic regression. Regardless of diagnostic category, participants had high BMI (average 30.3 kg/m2), and current smoking was common (42.4%). Diabetes and COPD were more common in SZ than in other diagnostic categories. The differences between psychotic disorders were not explained by obesity or smoking status only. Obesity and smoking were prevalent in all diagnostic categories of psychotic disorders, and continued efforts at prevention are warranted. Additional differences in GMC prevalence exist between psychotic disorders that are not explained by obesity and smoking.
C1 [Ahti, Johan; Wegelius, Asko; Isometsae, Erkki] Univ Helsinki, Dept Psychiat, Helsinki, Finland.
   [Ahti, Johan; Wegelius, Asko; Isometsae, Erkki] Helsinki Univ Hosp, Helsinki, Finland.
   [Kieseppae, Tuula] Hosp Dist Helsinki & Uusimaa, Helsinki, Finland.
   [Haaki, Willehard] Univ Turku, Dept Psychiat, Turku, Finland.
   [Haaki, Willehard; Niemelae, Solja] Turku Univ Hosp, Dept Psychiat, Turku, Finland.
   [Suvisaari, Jaana] Finnish Inst Hlth & Welf, Mental Hlth Team, Helsinki, Finland.
   [Niemelae, Solja] Hosp Dist South West, Dept Psychiat, Addict Psychiat Unit, Turku, Finland.
   [Suokas, Kimmo] Tampere Univ Hosp, Tampere, Finland.
   [Suokas, Kimmo] Pirkanmaa Hosp Dist, Dept Psychiat, Tampere, Finland.
   [Holm, Minna] Finnish Inst Hlth & Welf, Mental Hlth Unit, Helsinki, Finland.
   [Kampman, Olli] Umea Univ, Dept Clin Sci, Psychiat, SE-90187 Umea, Sweden.
   [Kampman, Olli] Univ Turku, Fac Med, Dept Clin Med Psychiat, Turku, Finland.
   [Kampman, Olli] Wellbeing Serv Cty Ostrobothn, Dept Psychiat, Vaasa, Finland.
   [Kampman, Olli] Pirkanmaa Wellbeing Serv Cty, Dept Psychiat, Tampere, Finland.
   [Laehteenvuo, Markku] Univ Eastern Finland, Niuvanniemi Hosp, Dept Forens Psychiat, Kuopio, Finland.
   [Paunio, Tiina] Univ Helsinki, Fac Med, SleepWell Res Program, Helsinki, Finland.
   [Paunio, Tiina] Univ Helsinki, Fac Med, Dept Psychiat, Helsinki, Finland.
   [Paunio, Tiina] Helsinki Univ Hosp, Helsinki, Finland.
   [Paunio, Tiina] Finnish Inst Hlth & Welf, Mental HealthUnit, Helsinki, Finland.
   [Tiihonen, Jari] Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden.
   [Tiihonen, Jari] Univ Eastern Finland, Niuvanniemi Hosp, Dept Forens Psychiat, Kuopio, Finland.
   [Hietala, Jarmo] Turku Univ Hosp, Dept Psychiat, Turku, Finland.
C3 University of Helsinki; University of Helsinki; Helsinki University
   Central Hospital; University of Helsinki; Helsinki University Central
   Hospital; University of Turku; University of Turku; Tampere University;
   Tampere University Hospital; Pirkanmaa Hospital District; Umea
   University; University of Turku; University of Eastern Finland;
   University of Helsinki; University of Helsinki; University of Helsinki;
   Helsinki University Central Hospital; Karolinska Institutet; University
   of Eastern Finland; University of Turku
RP Isometsae, E (corresponding author), Univ Helsinki, Dept Psychiat, Helsinki, Finland.
EM erkki.isometsa@hus.fi
RI Niemela, Solja/G-7084-2017; Suokas, Kimmo/AAT-3006-2020; Tiihonen,
   Jari/G-3078-2012; Lahteenvuo, Markku/AAG-7816-2020; Kampman,
   Olli/AAW-2352-2021; Isometsa, Erkki/K-8579-2014
OI Suvisaari, Jaana/0000-0001-7167-0990; Niemela,
   Solja/0000-0003-1130-9161; Suokas, Kimmo/0000-0001-6296-6343;
   Lahteenvuo, Markku/0000-0002-7244-145X; Hietala,
   Jarmo/0000-0002-3179-6780; Holm, Minna/0000-0003-2149-855X; Kampman,
   Olli/0000-0001-6891-2266; Isometsa, Erkki/0000-0001-5956-2399
FU Stanley Global Neuropsychiatric Genetics initiative
FX We would like to thank the collaborating SUPER study group: Aarno
   Palotie, Erik Cederlof, Mark Daly, Amanda Elliott, Willehard Haaki,
   Katriina Hakakari, Elina Hietala. Jarmo Hietala, Steve Hyman, Tuomas
   Jukuri, Risto Kajanne, Jaakko Keinanen, Martta Kerkela, Tuomo Kiiskinen,
   Aija Kyttala, Kaisla Lahdensuo, Sari Lang-Tonteri, Nina Lindberg, Jonne
   Lintunen, Jouko Lonnqvist, Ville Makipelto, Teemu Mannynsalo, Atiqul
   Mazumder, Zuzanna Misiewicz, Julia Moghadampour, Arto Mustonen, Benjamin
   Neale, Solja Niemela, Jussi Niemi-Pynttari, Olli Pietilainen, Susanna
   Rask, Noora Ristiluoma, Elmo Saarentaus, Anssi Solismaa, Andre
   Sourander, Heidi Taipale, Marjo Taivalantti, Antti Tanskanen, Auli
   Toivola, Lea Urpa, Imre Vastrik, and Juha Veijola for the SUPER study
   data and support. The SUPER-Finland study has been funded by the Stanley
   Global Neuropsychiatric Genetics initiative.
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NR 56
TC 0
Z9 0
U1 1
U2 1
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
EI 2754-6993
J9 SCHIZOPHRENIA-UK
JI Schizophr.
PD DEC 31
PY 2024
VL 10
IS 1
AR 124
DI 10.1038/s41537-024-00546-1
PG 8
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychiatry
GA Q7J9E
UT WOS:001386405400001
PM 39741144
OA gold
DA 2025-06-11
ER

PT J
AU Findling, JW
   Raff, H
AF Findling, James W.
   Raff, Hershel
TI Recognition of Nonneoplastic Hypercortisolism in the Evaluation of
   Patients With Cushing Syndrome
SO JOURNAL OF THE ENDOCRINE SOCIETY
LA English
DT Article
DE Cushing disease; ACTH; cortisol; hypothalamic-pituitary-adrenal axis;
   desmopressin; corticotrophs
ID CORTICOTROPIN-RELEASING HORMONE; PITUITARY-ADRENAL AXIS; DESMOPRESSIN
   STIMULATION TEST; TYPE-2 DIABETIC-PATIENTS; V3 VASOPRESSIN RECEPTOR;
   OBSTRUCTIVE SLEEP-APNEA; CHRONIC KIDNEY-DISEASE; CHRONIC-RENAL-FAILURE;
   SALIVARY CORTISOL; ANOREXIA-NERVOSA
AB The evaluation of suspected hypercortisolism is one of the most challenging problems in medicine. The signs and symptoms described by Dr Harvey Cushing are common and often create diagnostic confusion to even experienced endocrinologists. Cushing syndrome is classically defined as neoplastic hypercortisolism resulting from an ACTH-secreting tumor or from autonomous secretion of excess cortisol associated with benign or malignant adrenal neoplasia. The increasing recognition of the negative cardiometabolic effects of mild cortisol excess without overt physical signs of Cushing syndrome has led to more screening for endogenous hypercortisolism in patients with adrenal nodular disease, osteoporosis, and the metabolic syndrome. However, sustained or intermittent activation of the dynamic hypothalamic-pituitary-adrenal axis caused by chemical (alcohol), inflammatory (chronic kidney disease), psychologic (major depression), and physical (starvation/chronic intense exercise) stimuli can result in clinical and/or biochemical features indistinguishable from neoplastic hypercortisolism. Nonneoplastic hypercortisolism (formerly known as pseudo-Cushing syndrome) has been recognized for more than 50 years and often causes diagnostic uncertainty. This expert consultation describes two patients with features of Cushing syndrome who were referred for inferior petrosal sinus sampling for the differential diagnosis of ACTH-dependent hypercortisolism. Both patients were discovered to have nonneoplastic hypercortisolism: one from a covert alcohol use disorder and the other to chronic kidney disease. This consultation emphasizes the value of a good history and physical examination, appropriate laboratory testing, and the desmopressin acetate stimulation test to aid in distinguishing neoplastic from nonneoplastic hypercortisolism.
C1 [Findling, James W.; Raff, Hershel] Med Coll Wisconsin, Dept Med Endocrinol & Mol Med, Milwaukee, WI 53226 USA.
   [Findling, James W.; Raff, Hershel] Med Coll Wisconsin, Dept Surg, Milwaukee, WI 53226 USA.
   [Raff, Hershel] Med Coll Wisconsin, Dept Physiol, Milwaukee, WI 53226 USA.
   [Raff, Hershel] Med Coll Wisconsin, Cardiovasc Ctr, Milwaukee, WI 53226 USA.
   [Raff, Hershel] Med Coll Wisconsin, Endocrinol Res HRC4150, 8701 Watertown Plank Rd, Milwaukee, WI 53226 USA.
C3 Medical College of Wisconsin; Medical College of Wisconsin; Medical
   College of Wisconsin; Medical College of Wisconsin; Medical College of
   Wisconsin
RP Raff, H (corresponding author), Med Coll Wisconsin, Endocrinol Res HRC4150, 8701 Watertown Plank Rd, Milwaukee, WI 53226 USA.
EM hraff@mcw.edu
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NR 161
TC 11
Z9 11
U1 0
U2 4
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
EI 2472-1972
J9 J ENDOCR SOC
JI J. Endocr. Soc.
PD JUL 3
PY 2023
VL 7
IS 8
AR bvad087
DI 10.1210/jendso/bvad087
PG 12
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA L8VA5
UT WOS:001025974900001
PM 37440963
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Black, PH
AF Black, Paul H.
TI The inflammatory consequences of psychologic stress: Relationship to
   insulin resistance, obesity, atherosclerosis and diabetes mellitus, type
   II
SO MEDICAL HYPOTHESES
LA English
DT Article
ID C-REACTIVE PROTEIN; ENDOTHELIUM-DEPENDENT DILATATION; WHITE
   ADIPOSE-TISSUE; METABOLIC SYNDROME; NERVOUS-SYSTEM; BLOOD-PRESSURE;
   FATTY-ACIDS; WEIGHT-LOSS; CARDIOVASCULAR-DISEASE; PSYCHOSOCIAL STRESS
AB Inflammation is frequently present in the visceral fat and vasculature in certain patients with cardiovascular disease (CVD) and/or adult onset Diabetes Mellitus Type 11 (NIDDM). An hypothesis is presented which argues that repeated acute or chronic psychologically stressful states may cause this inflammatory process. The mediators are the major stress hormones norepinephrine (NE) and epinephrine (E) and cortisol together with components of the renin-angiotensin system (RAS), the proinflammatory cytokines (PIC), as well as free fatty acids (ffa), the latter as a result of lipolysis of neutral fat. NE/E commence this process by activation of NF kappa B in macrophages, visceral fat, and endothelial cells which induces the production of toll-like receptors which, when engaged, produce a cascade of inflammatory reactions comprising the acute phase response (APR) of the innate immune system (IIS). The inflammatory process is most marked in the visceral fat depot as well as the vasculature, and is involved in the metabolic events which culminate in the insulin resistance/ metabolic syndromes (IRS/MS), the components of which precede and comprise the major risk factors for CVD and NIDDM.
   The visceral fat has both the proclivity and capacity to undergo inflammation. It contains a rich blood and nerve supply as well as proinflammatory molecules such as interleukin 6 (IL-6), tumor necrosis factor alpha (TNF alpha), leptin, and resistin, the adipocytokines, and acute phase proteins (APP) which are activated from adipocytes and/or macrophages by sympathetic signaling. The inflammation is linked to fat accumulation. Cortisol, IL-6, angiotensin II (angio II), the enzyme 11(beta) hydroxysteroid dehydrogenase-1 and positive energy balance, the Latter due to increased appetite induced by the major stress hormones, are factors which promote fat accumulation and are Linked to obesity. There is also the capacity of the host to limit fat expansion. Sympathetic signaling induces TNF which stimulates the production of IL-6 and leptin from adipocytes; these molecules promote lipolysis and ffa fluxes from adipocytes. Moreover, catechotamines and certain PIC inhibit lipoprotein tipase, a fat synthesizing enzyme.
   The brain also participates in the regulation of fat cell mass; it is informed of fat depot mass by molecules such as leptin and ffa. Leptin stimulates corticotrophin releasing hormone in the brain which stimulates the SNS and HPA axes, i.e. the stress response. Also, ffa through portal signaling from the liver evoke a similar stress response which, like the response to psychologic stress, evokes an innate immune response (IIR), tending to limit fat expansion, which culminates in inflammatory cascades, the IRS-MS, obesity and disease if prolonged. Thus, the brain also has the capacity to limit fat expansion. A competition apparently exists between fat expansion and fat toss. In "western" cultures with excessive food ingestion, obesity frequently results. The linkage of inflammation to fat metabolism is apparent since weight loss diminishes the concentration of inflammatory mediators.
   The linkage of stress to inflammation is all the more apparent since the efferent pathways from the brain in response to fat signals, which results in inflammation to decrease and limit fat cell mass, is the same as the response to psychologic stress, which strengthens the hypothesis presented herein. (c) 2006 Elsevier Ltd. All rights reserved.
C1 Boston Univ, Sch Med, Dept Microbiol, Boston, MA 02118 USA.
C3 Boston University
RP Black, PH (corresponding author), Boston Univ, Sch Med, Dept Microbiol, 715 Albany St,Room L-501, Boston, MA 02118 USA.
EM pblack@bu.edu
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NR 95
TC 195
Z9 250
U1 2
U2 35
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0306-9877
EI 1532-2777
J9 MED HYPOTHESES
JI Med. Hypotheses
PY 2006
VL 67
IS 4
BP 879
EP 891
DI 10.1016/j.mehy.2006.04.008
PG 13
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 074XZ
UT WOS:000239847100037
PM 16781084
DA 2025-06-11
ER

PT J
AU Purewal, JS
   Doshi, GM
AF Purewal, Japneet Singh
   Doshi, Gaurav Mahesh
TI Deciphering the Function of New Therapeutic Targets and Prospective
   Biomarkers in the Management of Psoriasis
SO CURRENT DRUG TARGETS
LA English
DT Review
DE Psoriasis; autoimmune; biomarkers; antimicrobial peptides;
   interleukin-38; autophagy protein and squamous cell carcinoma antigen
ID NF-KAPPA-B; OSTRACEOUS PSORIASIS; RUPIOID PSORIASIS; IL-36 RECEPTOR;
   S100 PROTEINS; AUTOPHAGY; CELLS; INFLAMMATION; EXPRESSION; ARTHRITIS
AB Psoriasis is an immune-mediated skin condition affecting people worldwide, presenting at any age, and leading to a substantial burden physically and mentally. The innate and adaptive immune systems interact intricately with the pathomechanisms that underlie disease. T cells can interact with keratinocytes, macrophages, and dendritic cells through the cytokines they secrete. According to recent research, psoriasis flare-ups can cause systemic inflammation and various other co-morbidities, including depression, psoriatic arthritis, and cardio-metabolic syndrome. Additionally, several auto-inflammatory and auto-immune illnesses may be linked to psoriasis. Although psoriasis has no proven treatment, care must strive by treating patients as soon as the disease surfaces, finding and preventing concurrent multimorbidity, recognising and reducing bodily and psychological distress, requiring behavioural modifications, and treating each patient individually. Biomarkers are traits that are assessed at any time along the clinical continuum, from the early stages of a disease through the beginning of treatment (the foundation of precision medicine) to the late stages of treatment (outcomes and endpoints). Systemic therapies that are frequently used to treat psoriasis provide a variety of outcomes. Targeted therapy selection, better patient outcomes, and more cost-effective healthcare would be made possible by biomarkers that reliably predict effectiveness and safety. This review is an attempt to understand the role of Antimicrobial peptides (AMP), Interleukin-38 (IL-38), autophagy 5 (ATG5) protein and squamous cell carcinoma antigen (SCCA) as biomarkers of psoriasis.
C1 [Purewal, Japneet Singh; Doshi, Gaurav Mahesh] SVKMs Dr Bhanuben Nanavati Coll Pharm, Dept Pharmacol Toxicol & Therapeut, VM Rd,Vile Parle W, Mumbai, India.
RP Doshi, GM (corresponding author), SVKMs Dr Bhanuben Nanavati Coll Pharm, Dept Pharmacol Toxicol & Therapeut, VM Rd,Vile Parle W, Mumbai, India.
EM gaurav.pharmacology@gmail.com
RI Doshi, Gaurav/AAV-3681-2021
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NR 181
TC 3
Z9 3
U1 3
U2 3
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1389-4501
EI 1873-5592
J9 CURR DRUG TARGETS
JI Curr. Drug Targets
PY 2023
VL 24
IS 16
BP 1224
EP 1238
DI 10.2174/0113894501277656231128060242
PG 15
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA GF0D5
UT WOS:001151124400005
PM 38037998
DA 2025-06-11
ER

PT J
AU Yang, C
   Lin, XX
   Wang, XT
   Liu, HZ
   Huang, JY
   Wang, S
AF Yang, Chao
   Lin, Xiaoxiao
   Wang, Xianteng
   Liu, Huanzhong
   Huang, Jinyu
   Wang, Shuai
TI The schizophrenia and gut microbiota: A bibliometric and visual analysis
SO FRONTIERS IN PSYCHIATRY
LA English
DT Article
DE gut microbiota; bibliometric analysis; gut-brain axis; schizophrenia;
   antipsychotics
ID WEIGHT-GAIN; COMPARATIVE EFFICACY; INFLAMMATION; ANTIPSYCHOTICS;
   TOLERABILITY; DYSFUNCTION; OLANZAPINE; GLUTAMATE; IMMUNITY; OBESITY
AB BackgroundMany studies have explored the link between the gut microbiota and schizophrenia. To date, there have been no bibliometric analyses to summarize the association between the gut microbiota and schizophrenia. We aimed to conduct a bibliometric study of this association to determine the current status and areas for advancement in this field. Materials and methodsPublications related to the gut microbiota and schizophrenia were retrieved from the Web of Science Core Collection (WoSCC). The WoSCC literature analysis wire and VOSviewer 1.6.16 were used to conduct the analysis. ResultsIn total, 162 publications were included in our study. The publications generally showed an upward trend from 2014. A total of 873 authors from 355 organizations and 40 countries/regions contributed to this field. The leading authors were Timothy Dinan, John F Cryan, and Emily Severance. The leading institutions were Johns Hopkins University, the University College Cork, and the University of Toronto. The most productive countries were the United States (US), China, and Canada. In total, 95 journals contributed to this field. Among them, the top three productive journals were Schizophrenia Research, Progress in Neuro Psychopharmacology Biological Psychiatry, and Frontiers in Psychiatry. The important keywords in the clusters were gut microbiome, bipolar disorder, schizophrenia, antipsychotics, weight gain, metabolic syndrome, gut-brain axis, autism, depression, inflammation, and brain. ConclusionThe main research hotspots involving the connection between schizophrenia and the gut microbiota were the characteristics of the microbiota composition in schizophrenia patients, the gut-brain axis, and microbial-based interventions for schizophrenia. The studies about the association between gut microbiota and schizophrenia are limited, and more studies are needed to provide new insights into the gut microbiota in the pathogenesis and treatment of schizophrenia.
C1 [Yang, Chao] Capital Med Univ, Beijing Luhe Hosp, Dept Psychiat, Beijing, Peoples R China.
   [Lin, Xiaoxiao] Zhejiang Chinese Med Univ, Sch Clin Med 4, Hangzhou, Peoples R China.
   [Wang, Xianteng] Shenzhen Univ, Guangdong Key Lab Biomed Measurements & Ultrasound, Sch Biomed Engn, Hlth Sci Ctr, Shenzhen, Peoples R China.
   [Wang, Xianteng] Shenzhen Univ, Int Canc Ctr, Shenzhen Peoples Hosp 2, Shenzhen Inst Translat Med,Affiliated Hosp 1, Shenzhen, Peoples R China.
   [Liu, Huanzhong] Anhui Med Univ, Chaohu Hosp, Dept Psychiat, Chaohu, Peoples R China.
   [Huang, Jinyu] Zhejiang Univ, Affiliated Hangzhou Peoples Hosp 1, Dept Cardiol, Sch Med, Hangzhou, Peoples R China.
   [Wang, Shuai] Zhejiang Univ, Affiliated Hangzhou Peoples Hosp 1, Dept Translat Med Ctr, Sch Med, Hangzhou, Peoples R China.
C3 Capital Medical University; Zhejiang Chinese Medical University;
   Shenzhen University; Shenzhen University; Anhui Medical University;
   Zhejiang University; Zhejiang University
RP Huang, JY (corresponding author), Zhejiang Univ, Affiliated Hangzhou Peoples Hosp 1, Dept Cardiol, Sch Med, Hangzhou, Peoples R China.; Wang, S (corresponding author), Zhejiang Univ, Affiliated Hangzhou Peoples Hosp 1, Dept Translat Med Ctr, Sch Med, Hangzhou, Peoples R China.
EM zdsyhjy0902@zju.edu.cn; drwangshuai@zju.edu.cn
RI Liu, Huanzhong/T-5968-2018
OI Liu, Huanzhong/0000-0003-3095-5249
FU China Postdoctoral Science Foundation [2021M692802]; Key Research and
   Development Program of Zhejiang Province [2020C03018]
FX This research was supported by the fellowship of China Postdoctoral
   Science Foundation (Grant No. 2021M692802) and the Key Research and
   Development Program of Zhejiang Province (Grant No. 2020C03018).
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TC 15
Z9 15
U1 1
U2 30
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-0640
J9 FRONT PSYCHIATRY
JI Front. Psychiatry
PD NOV 15
PY 2022
VL 13
AR 1022472
DI 10.3389/fpsyt.2022.1022472
PG 12
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 6P9KE
UT WOS:000891242100001
PM 36458121
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Park, JH
   Moon, JH
   Kim, HJ
   Kong, MH
   Oh, YH
AF Park, Jung Ha
   Moon, Ji Hyun
   Kim, Hyeon Ju
   Kong, Mi Hee
   Oh, Yun Hwan
TI Sedentary Lifestyle: Overview of Updated Evidence of Potential Health
   Risks
SO KOREAN JOURNAL OF FAMILY MEDICINE
LA English
DT Review
DE Sedentary Behavior; All-Cause Mortality; Cancer; Metabolic Disease;
   Physical Activity; Exercise
ID INDUCED BONE LOSS; PHYSICAL-ACTIVITY; BED REST; SITTING TIME; TREADMILL
   EXERCISE; METABOLIC SYNDROME; MORTALITY; BEHAVIOR; INACTIVITY; OBESITY
AB One-third of the global population aged 15 years and older engages in insufficient physical activities, which affects health. However, the health risks posed by sedentary behaviors are not well known. The mean daily duration of sedentary behavior is 8.3 hours among the Korean population and 7.7 hours among the American adult population. Sedentary lifestyles are spreading worldwide because of a lack of available spaces for exercise, increased occupational sedentary behaviors such as office work, and the increased penetration of television and video devices. Consequently, the associated health problems are on the rise. A sedentary lifestyle affects the human body through various mechanisms. Sedentary behaviors reduce lipoprotein lipase activity, muscle glucose, protein transporter activities, impair lipid metabolism, and diminish carbohydrate metabolism. Furthermore, it decreases cardiac output and systemic blood flow while activating the sympathetic nervous system, ultimately reducing insulin sensitivity and vascular function. It also alters the insulin-like growth factor axis and the circulation levels of sex hormones, which elevates the incidence of hormone-related cancers. Increased sedentary time impairs the gravitostat, the body's weight homeostat, and weight gain, adiposity, and elevated chronic inflammation caused by sedentary behavior are risk factors for cancer Sedentary behaviors have wide-ranging adverse impacts on the human body including increased all-cause mortality, cardiovascular disease mortality, cancer risk, and risks of metabolic disorders such as diabetes mellitus, hypertension, and dyslipidemia; musculoskeletal disorders such as arthralgia and osteoporosis; depression; and, cognitive impairment. Therefore, reducing sedentary behaviors and increasing physical activity are both important to promote public health.
C1 [Park, Jung Ha; Moon, Ji Hyun; Kim, Hyeon Ju; Kong, Mi Hee; Oh, Yun Hwan] Jeju Natl Univ Hosp, Dept Family Med, Jeju, South Korea.
   [Moon, Ji Hyun; Kim, Hyeon Ju; Kong, Mi Hee; Oh, Yun Hwan] Jeju Natl Univ, Dept Family Med, Sch Med, Jeju, South Korea.
C3 Jeju National University; Jeju National University
RP Oh, YH (corresponding author), Jeju Natl Univ Hosp, Dept Family Med, Jeju, South Korea.; Oh, YH (corresponding author), Jeju Natl Univ, Dept Family Med, Sch Med, Jeju, South Korea.
EM swimayo@gmail.com
RI SeungTaek, lim/C-8232-2015
OI Kim, Hyeon Ju/0000-0002-9103-3275; Park, Jungha/0000-0002-1269-333X;
   Moon, Ji Hyun/0000-0001-6788-7521; Oh, Yun Hwan/0000-0002-1627-7528
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NR 61
TC 425
Z9 468
U1 6
U2 75
PU KOREAN ACAD FAMILY MEDICINE
PI SEOUL
PA GWANGHWAMUN OFFICIA 2003, SINMUNNO 1-GA, JONGNO-GU, SEOUL, 110-999,
   SOUTH KOREA
SN 2092-6715
J9 KOREAN J FAM MED
JI Korean J. Fam. Med.
PD NOV
PY 2020
VL 41
IS 6
BP 365
EP 373
DI 10.4082/kjfm.20.0165
PG 9
WC Primary Health Care
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA OW3CN
UT WOS:000592769400002
PM 33242381
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU El-Bassossy, HM
   Watson, ML
AF El-Bassossy, Hany M.
   Watson, Malcolm L.
TI Xanthine oxidase inhibition alleviates the cardiac complications of
   insulin resistance: effect on low grade inflammation and the angiotensin
   system
SO JOURNAL OF TRANSLATIONAL MEDICINE
LA English
DT Article
DE Metabolic syndrome; Heart; Hypertension; Xanthine oxidase; Allopurinol
ID URIC-ACID; HYPERTENSION; ALLOPURINOL; REPOLARIZATION; ACCUMULATION;
   PATHOGENESIS; MODELS
AB Background: We have previously shown that hyperuricemia plays an important role in the vascular complications of insulin resistance (IR). Here we investigated the effect of xanthine oxidase (XO) inhibition on the cardiac complications of IR.
   Methods: IR was induced in rats by a high fructose high fat diet for 12 weeks. Allopurinol, a standard XO inhibitor, was administered in the last 4 weeks before cardiac hemodynamics and electrocardiography, serum glucose, insulin, tumor necrosis factor alpha (TNFa), 8-isoprostane, uric acid, lactate dehydrogenase (LDH) and XO activity were measured. Expression of cardiac angiotensin II (AngII) and angiotensin receptor 1 (AT(1)) were assessed by immunofluorescence.
   Results: IR animals had significant hyperuricemia which was inhibited by allopurinol administration. IR was associated with impaired ventricular relaxation (reflected by a decreased diastolic pressure increment and prolonged diastolic duration) and XO inhibition greatly attenuated impaired relaxation. IR was accompanied by cardiac ischemia (reflected by increased QTc and T peak trend intervals) while XO inhibition alleviated the ECG abnormalities. When subjected to isoproterenol-induced ischemia, IR hearts were less resistant (reflected by larger ST height depression and higher LDH level) while XO inhibition alleviated the accompanying ischemia. In addition, XO inhibition prevented the elevation of serum 8-isoprostane and TNFa, and blocked elevated AngII and AT1 receptor expression in the heart tissue of IR animals. However, XO inhibition did not affect the developed hyperinsulinemia or dyslipidemia.
   Conclusions: XO inhibition alleviates cardiac ischemia and impaired relaxation in IR through the inhibition of low grade inflammation and the angiotensin system.
C1 [El-Bassossy, Hany M.] King Abdulaziz Univ, Fac Pharm, Dept Pharmacol & Toxicol, Jeddah 21413, Saudi Arabia.
   [El-Bassossy, Hany M.] Zagazig Univ, Fac Pharm, Dept Pharmacol & Toxicol, Zagazig, Egypt.
   [Watson, Malcolm L.] Univ Bath, Dept Pharm & Pharmacol, Bath BA2 7AY, Avon, England.
C3 King Abdulaziz University; Egyptian Knowledge Bank (EKB); Zagazig
   University; University of Bath
RP El-Bassossy, HM (corresponding author), King Abdulaziz Univ, Fac Pharm, Dept Pharmacol & Toxicol, Jeddah 21413, Saudi Arabia.
EM helbassossy@kau.edu.sa
RI El-Bassossy, Hany/NKQ-3705-2025; Watson, Malcolm/AAA-6435-2020;
   El-Bassossy, Hany/I-1576-2012
OI Watson, Malcolm/0000-0001-9902-9521; El-Bassossy,
   Hany/0000-0002-6838-6945
FU Deanship of Scientific Research (DSR), King Abdulaziz University, Jeddah
   [166-006-D1434]
FX This work was funded by the Deanship of Scientific Research (DSR), King
   Abdulaziz University, Jeddah, under grant No. (166-006-D1434). The
   authors, therefore, acknowledge with thanks DSR technical and financial
   support.
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NR 39
TC 32
Z9 32
U1 0
U2 9
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1479-5876
J9 J TRANSL MED
JI J. Transl. Med.
PD MAR 6
PY 2015
VL 13
AR 82
DI 10.1186/s12967-015-0445-9
PG 11
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA CC8NH
UT WOS:000350624900001
PM 25889404
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Fulda, S
   Linseisen, J
   Wolfram, G
   Himmerich, S
   Gedrich, K
   Pollmächer, T
   Himmerich, H
AF Fulda, Stephany
   Linseisen, Jakob
   Wolfram, Guenther
   Himmerich, Stephanie
   Gedrich, Kurt
   Pollmaecher, Thomas
   Himmerich, Hubertus
TI Leptin Plasma Levels in the General Population: Influence of Age,
   Gender, Body Weight and Medical History
SO PROTEIN AND PEPTIDE LETTERS
LA English
DT Article
DE Leptin; gender; body weight; age
ID SERUM URIC-ACID; METABOLIC SYNDROME; TNF-ALPHA; DEPRESSION; OBESE
AB The polypeptide leptin exerts a multitude of regulatory functions. It has been implicated in the pathophysiology of inflammatory, metabolic and psychiatric disorders and has been found to be differentially expressed in men and women. Although a clear increase of leptin levels with age has been repeatedly observed in men, the association of leptin levels and age in women is an issue of scientific discussion. To investigate the association of age, gender, body mass index (BMI) and selected diseases with plasma levels of leptin in 551 adults randomly chosen from the Bavarian population, we assessed subjects' characteristics, lifestyle, and medical history including life time history of frequent diseases and performed blood sampling and standardized anthropometric measurements. Leptin plasma levels were measured using a Radioimmunoassay. Leptin levels were significantly higher in women as compared to men and this difference persisted even after controlling for differences in age or BMI. Leptin levels increased across the age groups in both men and women. Controlling for differences in BMI substantially attenuated the influence of age on leptin levels. In women, age was no longer significantly associated with leptin levels after controlling for BMI. With regard to medical history, hyperuricemia and gout were significantly associated with higher leptin levels, even after controlling for BMI, whereas subjects with high blood pressure or dyslipoproteinemia showed higher leptin levels only if the BMI was not considered as control variable. The BMI and its influence on the interrelations of gender, age and leptin should be considered when interpreting leptin levels.
C1 [Himmerich, Hubertus] Univ Leipzig, Dept Psychiat & Psychotherapy, D-04103 Leipzig, Germany.
   [Fulda, Stephany; Pollmaecher, Thomas; Himmerich, Hubertus] Max Planck Inst Psychiat, D-80804 Munich, Germany.
   [Linseisen, Jakob] Helmholtz Zentrum Munchen, Inst Epidemiol, D-85764 Neuherberg, Germany.
   [Wolfram, Guenther] Tech Univ Munich, Dept Food & Nutr, D-85350 Freising Weihenstephan, Germany.
   [Himmerich, Stephanie; Gedrich, Kurt] Tech Univ Munich, Dept Mkt & Consumer Res, D-85350 Freising Weihenstephan, Germany.
   [Pollmaecher, Thomas] Klinikum Ingolstadt, Ctr Mental Hlth, D-85049 Ingolstadt, Germany.
C3 Leipzig University; Max Planck Society; Helmholtz Association;
   Helmholtz-Center Munich - German Research Center for Environmental
   Health; Technical University of Munich; Technical University of Munich
RP Himmerich, H (corresponding author), Univ Leipzig, Dept Psychiat & Psychotherapy, Semmelweisstr 10, D-04103 Leipzig, Germany.
EM Hubertus.Himmerich@medizin.uni-leipzig.de
RI Gedrich, Kurt/I-2312-2019; Himmerich, Hubertus/H-9218-2019; Fulda,
   Stephany/C-6867-2013; Linseisen, Jakob/B-5353-2014
OI Fulda, Stephany/0000-0001-8416-2610; Himmerich,
   Hubertus/0000-0003-1209-6073; Linseisen, Jakob/0000-0002-9386-382X;
   Gedrich, Kurt/0000-0001-7321-2555
FU Kurt-Eberhard-Bode-Stiftung; Bavarian Ministry of Environment, Health,
   and Consumer Protection
FX The authors thank Gabriele Kohl for excellent technical assistance. The
   study was supported by funds of the Kurt-Eberhard-Bode-Stiftung and the
   Bavarian Ministry of Environment, Health, and Consumer Protection. We
   acknowledge the cooperation of the study participants as well as the
   work of all co-workers involved in the sampling of data and biological
   specimens. We especially thank the physicians from the health offices in
   Bavaria for providing study rooms and for blood sampling. Writing the
   manuscript was additionally supported by the Claussen Simon Foundation,
   AZ T082/17197/2007. We thank Ms Sindy Pampel for help in preparing the
   manuscript.
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NR 32
TC 20
Z9 21
U1 2
U2 5
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 0929-8665
EI 1875-5305
J9 PROTEIN PEPTIDE LETT
JI Protein Pept. Lett.
PD NOV
PY 2010
VL 17
IS 11
BP 1436
EP 1440
DI 10.2174/0929866511009011436
PG 5
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 685TV
UT WOS:000284651900016
PM 20666730
DA 2025-06-11
ER

PT J
AU Murata, GH
   Shah, JH
   Duckworth, WC
   Wendel, CS
   Mohler, MJ
   Hoffman, RM
AF Murata, GH
   Shah, JH
   Duckworth, WC
   Wendel, CS
   Mohler, MJ
   Hoffman, RM
TI Food frequency questionnaire results correlate with metabolic control in
   insulin-treated veterans with type 2 diabetes: The diabetes outcomes in
   veterans study
SO JOURNAL OF THE AMERICAN DIETETIC ASSOCIATION
LA English
DT Article
ID FOLLOW-UP SURVEY; DIETARY RECORDS; COHORT-I; ENERGY-EXPENDITURE;
   SELF-MANAGEMENT; VALIDITY; VALIDATION; ADULTS; JPHC; REPRODUCIBILITY
AB Objective To validate food frequency analysis as a predictor of metabolic status in persons with type 2 diabetes and to identify psychosocial factors affecting dietary adherence.
   Methods Three hundred forty-seven subjects with stable, insulin-treated type 2 diabetes completed a food frequency questionnaire and six instruments measuring different psychosocial attributes. Eight metabolic parameters were used as principal endpoints. Data from the food frequency questionnaires were used to estimate daily energy intake and determine each subject's adherence to seven dietary standards derived from the 2003 Dietary Recommendations of the American Diabetes Association. We excluded 105 subjects reporting daily energy intake <1,000 kcal because these results were considered unreliable. Subjects were then categorized into three groups depending on their adherence rates to American Diabetes Association dietary standards.
   Results Subjects with the lowest dietary adherence had the poorest metabolic control. Adherence to dietary standards was particularly poor among subjects with metabolic syndrome (2.1%) and/or obesity (4.1%). The most important determinants of following recommended dietary practices were positive attitudes, fewer social barriers, and a conviction that diet could control diabetes.
   Conclusions For subjects with type 2 diabetes reporting a dietary intake of >1,000 kcal/day, food frequency questionnaire data could identify those with poor metabolic control. Nutrition interventions to improve metabolic control should focus on reducing fat intake and emphasizing the importance of diet. Multidisciplinary efforts should be directed at overcoming social barriers to recommended dietary practices and to treating depression.
C1 New Mexico VA Hlth Care Syst, Albuquerque, NM 87108 USA.
   Univ New Mexico, Sch Med, Albuquerque, NM 87131 USA.
   Univ Arizona, Coll Med, Tucson, AZ 85721 USA.
   So Arizona Vet Affairs Hlth Care Syst, Hlth Serv Res Ctr, Tucson, AZ USA.
   Carl T Hayden Vet Affairs Med Ctr, Phoenix, AZ USA.
C3 University of New Mexico; University of Arizona; US Department of
   Veterans Affairs; Veterans Health Administration (VHA); Southern Arizona
   Veterans Affairs Health Care System
RP New Mexico VA Hlth Care Syst, 111GIM,1501 San Pedro Dr, Albuquerque, NM 87108 USA.
EM glen.murata@med.va.gov
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NR 53
TC 11
Z9 17
U1 0
U2 7
PU AMER DIETETIC ASSOC
PI CHICAGO
PA 120 S RIVERSIDE PLZ, STE 2000, CHICAGO, IL 60606-6995 USA
SN 0002-8223
J9 J AM DIET ASSOC
JI J. Am. Diet. Assoc.
PD DEC
PY 2004
VL 104
IS 12
BP 1816
EP 1826
DI 10.1016/j.jada.2004.09.026
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 877DX
UT WOS:000225549100012
PM 15565075
DA 2025-06-11
ER

PT J
AU Bock, M
   von Schacky, C
   Scherr, J
   Lorenz, E
   Lechner, B
   Krannich, A
   Wachter, R
   Duvinage, A
   Edelmann, F
   Lechner, K
AF Bock, Matthias
   von Schacky, Clemens
   Scherr, Johannes
   Lorenz, Elke
   Lechner, Benjamin
   Krannich, Alexander
   Wachter, Rolf
   Duvinage, Andre
   Edelmann, Frank
   Lechner, Katharina
TI De Novo Lipogenesis-Related Monounsaturated Fatty Acids in the Blood Are
   Associated with Cardiovascular Risk Factors in HFpEF Patients
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Article
DE de novo lipogenesis-related fatty acids; monounsaturated fatty acids;
   heart failure; HFpEF; metabolic phenotype; aerobic capacity
ID PRESERVED EJECTION FRACTION; HEART-FAILURE; LIVER-DISEASE; PALMITOLEIC
   ACID; MARKER
AB De novo lipogenesis (DNL)-related monounsaturated fatty acids (MUFAs) in the blood are associated with incident heart failure (HF). This observation's biological plausibility may be due to the potential of these MUFAs to induce proinflammatory pathways, endoplasmic reticulum stress, and insulin resistance, which are pathophysiologically relevant in HF. The associations of circulating MUFAs with cardiometabolic phenotypes in patients with heart failure with a preserved ejection fraction (HFpEF) are unknown. In this secondary analysis of the Aldosterone in Diastolic Heart Failure trial, circulating MUFAs were analysed in 404 patients using the HS-Omega-3-Index(& REG;) methodology. Patients were 67 & PLUSMN; 8 years old, 53% female, NYHA II/III (87/13%). The ejection fraction was & GE;50%, E/e & PRIME; 7.1 & PLUSMN; 1.5, and the median NT-proBNP 158 ng/L (IQR 82-298). Associations of MUFAs with metabolic, functional, and echocardiographic patient characteristics at baseline/12 months follow-up (12 mFU) were analysed using Spearman's correlation coefficients and linear regression analyses, using sex/age as covariates. Circulating levels of C16:1n7 and C18:1n9 were positively associated with BMI/truncal adiposity and associated traits (dysglycemia, atherogenic dyslipidemia, and biomarkers suggestive of non-alcoholic-fatty liver disease). They were furthermore inversely associated with functional capacity at baseline/12 mFU. In contrast, higher levels of C20:1n9 and C24:1n9 were associated with lower cardiometabolic risk and higher exercise capacity at baseline/12 mFU. In patients with HFpEF, circulating levels of individual MUFAs were differentially associated with cardiovascular risk factors. Our findings speak against categorizing FA based on physicochemical properties. Circulating MUFAs may warrant further investigation as prognostic markers in HFpEF.
C1 [Bock, Matthias; Lorenz, Elke; Lechner, Katharina] Tech Univ Munich, German Heart Ctr Munich, Dept Cardiol, Lazarettstr 36, D-80636 Munich, Germany.
   [Bock, Matthias; Duvinage, Andre; Lechner, Katharina] DZHK German Ctr Cardiovasc Res, Partner Site Munich, Munich Heart Alliance, Munich, Germany.
   [von Schacky, Clemens] Omegametrix, D-82152 Martinsried, Germany.
   [Scherr, Johannes] Univ Zurich, Univ Ctr Prevent & Sports Med, Balgrist Univ Hosp, CH-8008 Zurich, Switzerland.
   [Lechner, Benjamin] Ludwig Maximilians Univ Munchen, Dept Internal Med 4, D-80336 Munich, Germany.
   [Krannich, Alexander] Charite Univ Med Berlin, D-13353 Berlin, Germany.
   [Wachter, Rolf] Univ Hosp Leipzig, Clin & Policlin Cardiol, D-04103 Leipzig, Germany.
   [Wachter, Rolf] Georg August Univ, Univ Med Ctr Gottingen, Dept Cardiol & Pneumol, D-37099 Gottingen, Germany.
   [Wachter, Rolf] DZHK German Ctr Cardiovasc Res, Partner Site Gottingen, Gottingen, Germany.
   [Duvinage, Andre; Lechner, Katharina] Tech Univ Munich, Sch Med, Dept Prevent Rehabil & Sports Med, D-80992 Munich, Germany.
   [Edelmann, Frank] Deutsch Herzzentrum Charite, Dept Cardiol Angiol & Intens Care Med, Campus Virchow Klinikum,Augustenburger Pl 1, D-13353 Berlin, Germany.
   [Edelmann, Frank] Charite Univ Med Berlin, Charitepl 1, D-10117 Berlin, Germany.
   [Edelmann, Frank] Free Univ Berlin, Charitepl 1, D-10117 Berlin, Germany.
   [Edelmann, Frank] Humboldt Univ, Charitepl 1, D-10117 Berlin, Germany.
   [Edelmann, Frank] DZHK German Ctr Cardiovasc Res, Partner Site Berlin, Berlin, Germany.
C3 German Heart Centre Munich; Technical University of Munich; Munich Heart
   Alliance; German Centre for Cardiovascular Research; University of
   Zurich; University of Munich; Berlin Institute of Health; Free
   University of Berlin; Humboldt University of Berlin; Charite
   Universitatsmedizin Berlin; Leipzig University; University of Gottingen;
   UNIVERSITY GOTTINGEN HOSPITAL; German Centre for Cardiovascular
   Research; Technical University of Munich; German Heart Center Berlin;
   Berlin Institute of Health; Free University of Berlin; Humboldt
   University of Berlin; Charite Universitatsmedizin Berlin; Berlin
   Institute of Health; Free University of Berlin; Humboldt University of
   Berlin; Charite Universitatsmedizin Berlin; Berlin Institute of Health;
   Free University of Berlin; Humboldt University of Berlin; Charite
   Universitatsmedizin Berlin; Berlin Institute of Health; Free University
   of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin
   Berlin; German Centre for Cardiovascular Research
RP Lechner, K (corresponding author), Tech Univ Munich, German Heart Ctr Munich, Dept Cardiol, Lazarettstr 36, D-80636 Munich, Germany.; Lechner, K (corresponding author), DZHK German Ctr Cardiovasc Res, Partner Site Munich, Munich Heart Alliance, Munich, Germany.; Lechner, K (corresponding author), Tech Univ Munich, Sch Med, Dept Prevent Rehabil & Sports Med, D-80992 Munich, Germany.; Edelmann, F (corresponding author), Deutsch Herzzentrum Charite, Dept Cardiol Angiol & Intens Care Med, Campus Virchow Klinikum,Augustenburger Pl 1, D-13353 Berlin, Germany.; Edelmann, F (corresponding author), Charite Univ Med Berlin, Charitepl 1, D-10117 Berlin, Germany.; Edelmann, F (corresponding author), Free Univ Berlin, Charitepl 1, D-10117 Berlin, Germany.; Edelmann, F (corresponding author), Humboldt Univ, Charitepl 1, D-10117 Berlin, Germany.; Edelmann, F (corresponding author), DZHK German Ctr Cardiovasc Res, Partner Site Berlin, Berlin, Germany.
EM frank.edelmann@dhzc-charite.de; katharina.lechner@tum.de
RI Wachter, Rolf/AAA-4037-2020; Krannich, Alexander/AAR-1285-2021
OI Scherr, Johannes/0000-0001-9948-1024; Edelmann,
   Frank/0000-0003-4401-5936; Lorenz, Elke/0009-0000-6948-4224; Lechner,
   Katharina/0000-0002-3582-3512
FU German Foundation of Heart Research [F/19/18]; Federal Ministry of
   Education and Research [01GI0205, FKZ 01KG0506]
FX The German Foundation of Heart Research supported this work [F/19/18].
   The Federal Ministry of Education and Research grant 01GI0205 [clinical
   trial program Aldo-DHF (FKZ 01KG0506)] funded Aldo-DHF.
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NR 40
TC 1
Z9 1
U1 0
U2 0
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD AUG
PY 2023
VL 12
IS 15
AR 4938
DI 10.3390/jcm12154938
PG 16
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA O8LC5
UT WOS:001046259200001
PM 37568339
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Ksiadzyna, D
AF Ksiadzyna, Dorota
TI FECAL MICROBIOTA TRANSPLANTATION IN ADULTS AS A MODERN FORM OF PAST
   "COPROTHERAPY": HOPE OR HYPE?
SO ACTA POLONIAE PHARMACEUTICA
LA English
DT Review
DE intestinal microbiota; dysbiosis; fecal microbiota transplantation;
   Clostridium difficile; inflammatory bowel disorders; irritable bowel
   syndrome
ID CLOSTRIDIUM-DIFFICILE INFECTION; INFLAMMATORY-BOWEL-DISEASE;
   ULCERATIVE-COLITIS; INTESTINAL MICROBIOTA; GUT MICROBIOTA; FROZEN;
   PREVENTION; DIARRHEA; DONORS; PROBIOTICS
AB The influence of intestinal microbiota on human health and disease is of great importance. Fecal microbiota transplantation (FMT) defined as the transfer of the stool-derived microbiota of the distal gastrointestinal (GI) tract from a healthy donor to a patient with a disease attributable to intestinal dysbiosis is, in addition to the use of probiotics, prebiotics, synbiotics and eubiotics, one of the methods to restore eubiosis. Thorough medical history and physical examination followed by a set of blood and stool laboratory tests should be performed in a potential stool donor. Stool-derived microbiota may be administered through the upper and/or lower GI tract. FMT is believed to be a well-tolerated and, in general, safe procedure. The emergence of stool banks of frozen feces-derived material containing intestinal microbiota and the availability of convenient oral capsules with selected components of feces would definitely facilitate the use of this method in both research and the clinics. An inflammation caused by Clostridium difficile is the most often indication for FMT. Other conditions include inflammatory bowel disease, irritable bowel syndrome or the eradication of multi-drug resistant microorganisms. However, the list of potential indications rapidly increases. Further randomized double-blind studies in humans are needed to confirm a real benefit-risk ratio and clinical value of FMT, especially in extraintestinal disorders like obesity, diabetes mellitus, metabolic syndrome, fatty liver disease, hepatic encephalopathy, allergy, autism, depression or dementia.
C1 [Ksiadzyna, Dorota] Wroclaw Med Univ, Dept Pharmacol, 2 J Mikulicza Radeckiego St, PL-50345 Wroclaw, Poland.
C3 Wroclaw Medical University
RP Ksiadzyna, D (corresponding author), Wroclaw Med Univ, Dept Pharmacol, 2 J Mikulicza Radeckiego St, PL-50345 Wroclaw, Poland.
EM dorota.ksiadzyna@umed.wroc.pl
FU Wroclaw Medical University Foundation
FX I would like to acknowledge the organizers of the 2nd Conference of the
   Natural Drug Section of the Polish Pharmaceutical Society of the Wroclaw
   branch on the 19-20th of October 2019 in Glucholazy, Poland for their
   invaluable mounting support in preparing this publication. In addition,
   I gratefully acknowledge the generous financial contribution to article
   processing charges from the Wroclaw Medical University Foundation.
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NR 79
TC 0
Z9 0
U1 1
U2 15
PU POLSKIE TOWARZYSTWO FARMACEUTYCZNE
PI WARSAW
PA DLUGA 16, 00-238 WARSAW, POLAND
SN 0001-6837
EI 2353-5288
J9 ACTA POL PHARM
JI ACTA POL. PHARM.
PD MAY-JUN
PY 2020
VL 77
IS 3
BP 391
EP 401
DI 10.32383/appdr/122149
PG 11
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA MF6ZH
UT WOS:000545487500002
OA gold
DA 2025-06-11
ER

PT J
AU Chang, HH
   Chen, PS
AF Chang, Hui H.
   Chen, Po S.
TI Inflammatory Biomarkers for Mood Disorders - A Brief Narrative Review
SO CURRENT PHARMACEUTICAL DESIGN
LA English
DT Review
DE Inflammation; mood disorders; biomarker; C-reactive protein;
   pharmacotherapy; anti-inflammatory medications
ID C-REACTIVE PROTEIN; MAJOR DEPRESSIVE DISORDER; BIPOLAR II DISORDER;
   N-ACETYL CYSTEINE; DOUBLE-BLIND; COGNITIVE IMPAIRMENT; UNIPOLAR
   DEPRESSION; DEVELOPING DEMENTIA; METABOLIC SYNDROME; GUT MICROBIOTA
AB Background: The nervous system and the immune system interact consistently in the brain and peripheries. Inflammation in the brain not only alters the metabolism of neurotransmitters, but also causes network dysfunction, structural changes, and the development of mood symptomology in patients with mood disorders. In addition, the dysregulation of the neuroimmune axis in mood disorders drives multiple-system comorbidities. Furthermore, patients with low-grade inflammation are more likely to exhibit treatment resistance with both pharmacotherapy and non-pharmacotherapy.
   Objective: The aim of this review was to examine the available data regarding not only evidence of inflammation in the pathophysiology of mood disorders and their comorbid conditions, but also potential inflammatory biomarkers of mood disorders.
   Methods: Studies of the use of adjunct anti-inflammatory medications in mood disorders, and inflammatory biomarkers that may guide treatment outcomes in mood disorders, were summarized.
   Results: Studies have demonstrated that certain adjunct anti-inflammatory medications might help to improve mood symptoms and reduce comorbidities, and the baseline levels of inflammatory biomarkers, such as peripheral C-reactive protein (CRP), could be used to stratify the treatment outcome. All results suggested that the identification of peripheral and brain inflammatory biomarkers for the diagnosis, outcome prediction, staging, and stratification of interventions of mood disorders has emerged as an important area of translational research in psychiatry.
   Conclusion: Inflammatory biomarkers could guide interventions and enhance treatment response in patients with mood disorders. The main challenge is that substantial complexities might hamper the attainment of this goal.
C1 [Chang, Hui H.] Natl Cheng Kung Univ, Coll Med, Inst Clin Pharm & Pharmaceut Sci, Tainan, Taiwan.
   [Chang, Hui H.] Natl Cheng Kung Univ, Coll Med, Sch Pharm, Tainan, Taiwan.
   [Chang, Hui H.] Natl Cheng Kung Univ, Natl Cheng Kung Univ Hosp, Coll Med, Dept Pharm, Tainan, Taiwan.
   [Chang, Hui H.] Natl Cheng Kung Univ Hosp, Dept Pharm, Dou Liou Branch, Touliu, Yunlin, Taiwan.
   [Chen, Po S.] Natl Cheng Kung Univ, Natl Cheng Kung Univ Hosp, Coll Med, Dept Psychiat, 138 Sheng Li Rd, Tainan 70403, Taiwan.
   [Chen, Po S.] Natl Cheng Kung Univ, Coll Med, Inst Behav Med, Tainan, Taiwan.
C3 National Cheng Kung University; National Cheng Kung University; National
   Cheng Kung University; National Cheng Kung University Hospital; National
   Cheng Kung University; National Cheng Kung University Hospital; National
   Cheng Kung University; National Cheng Kung University Hospital; National
   Cheng Kung University
RP Chen, PS (corresponding author), Natl Cheng Kung Univ, Natl Cheng Kung Univ Hosp, Coll Med, Dept Psychiat, 138 Sheng Li Rd, Tainan 70403, Taiwan.
EM chenps@mail.ncku.edu.tw
RI Chang, Hui/AGD-4270-2022; Chen, Po/AAA-6492-2021
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NR 129
TC 11
Z9 11
U1 1
U2 18
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1381-6128
EI 1873-4286
J9 CURR PHARM DESIGN
JI Curr. Pharm. Design
PY 2020
VL 26
IS 2
BP 236
EP 243
DI 10.2174/1381612826666200115100726
PG 8
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Pharmacology & Pharmacy
GA KT2RK
UT WOS:000518863000005
PM 31939727
DA 2025-06-11
ER

PT J
AU Singh, SM
   Surendran, I
   Jain, S
   Sharma, A
   Dua, D
   Shouan, A
   Avasthi, A
AF Singh, Shubh Mohan
   Surendran, Indu
   Jain, Sanjay
   Sharma, Akhilesh
   Dua, Devakshi
   Shouan, Anish
   Avasthi, Ajit
TI The prevalence of non-communicable disease risk factors in
   community-living patients with psychiatric disorders: A study from North
   India
SO ASIAN JOURNAL OF PSYCHIATRY
LA English
DT Article
DE Non-communicable disease; Non-communicable disease risk factors; Mental
   illness; Depression; Common mental disorders; Hypertension; Obesity;
   Physical activity; Community; Tobacco; Alcohol
ID COMMON MENTAL-DISORDERS; METABOLIC SYNDROME; CONSENSUS STATEMENT;
   ABDOMINAL OBESITY; PHYSICAL-ACTIVITY; METAANALYSIS
AB Objective: Screening for non-communicable disease (NCD) risk factors can help in prevention or reduction in the ill-effects of NCDs. Data on NCD risk factors in community-dwelling patients with common mental disorders (CMD) is lacking. This study was designed to screen for selected NCD risk factors in patients attending a community psychiatry service (CPS) in the states of Punjab and Haryana in North India.
   Methods: Following ethical clearance, the study was conducted in 4 satellite clinics of the CPS of a tertiary hospital from North India. Consecutive adult patients were approached and 719 patients were assessed. A one-time cross-sectional assessment was carried out which included socio-demographic data, clinical details, history of tobacco and alcohol use, personal history of hypertension and diabetes, family history of diabetes, prevalence of hypertension, obesity (central and generalised) and levels of physical activity.
   Results: 302 males and 417 females were assessed. Most patients were diagnosed with CMD. The prevalence of hypertension was 42.7% in males and 34.1% in females. The prevalence of central and generalised obesity in males and females was 41.4%, 71.2% and 34.8%, 45.6% respectively. 32.5% of males and 40.2% females were assessed to be inadequately physically active.
   Conclusions: The results of the study suggest that there is high prevalence of NCD risk factors in patients with CMD. Hypertension is more common in males while obesity and inadequate physical activity is more common in females. NCD risk factor screening and management, health education should be integrated in CPS.
C1 [Singh, Shubh Mohan; Surendran, Indu; Sharma, Akhilesh; Dua, Devakshi; Shouan, Anish; Avasthi, Ajit] Postgrad Inst Med Educ & Res, Dept Psychiat, Chandigarh 160012, India.
   [Jain, Sanjay] Postgrad Inst Med Educ & Res, Dept Internal Med, Chandigarh 160012, India.
C3 Post Graduate Institute of Medical Education & Research (PGIMER),
   Chandigarh; Post Graduate Institute of Medical Education & Research
   (PGIMER), Chandigarh
RP Singh, SM (corresponding author), Postgrad Inst Med Educ & Res, Dept Psychiat, Chandigarh 160012, India.
EM shubhmohan@gmail.com
OI Jain, Sanjay K/0000-0002-9241-3114; Singh, Shubh
   Mohan/0000-0001-8533-6600
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NR 29
TC 5
Z9 5
U1 0
U2 2
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1876-2018
EI 1876-2026
J9 ASIAN J PSYCHIATR
JI Asian J. Psychiatr.
PD MAR
PY 2019
VL 41
BP 23
EP 27
DI 10.1016/j.ajp.2019.03.004
PG 5
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychiatry
GA HR5TY
UT WOS:000463211000006
PM 30878917
DA 2025-06-11
ER

PT J
AU Zhang, XX
   Zhang, YY
   Yu, YA
   Liu, J
   Yuan, Y
   Zhao, YJ
   Li, HX
   Wang, J
   Wang, Z
AF Zhang, Xiaoxu
   Zhang, Yingying
   Yu, Yanan
   Liu, Jun
   Yuan, Ye
   Zhao, Yijun
   Li, Haixia
   Wang, Jie
   Wang, Zhong
TI Convergence and divergence of genetic and modular networks between
   diabetes and breast cancer
SO JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
LA English
DT Article
DE breast cancer; diabetes; type 2 diabetes; gene interaction network;
   modularized analysis
ID GROWTH-FACTOR-I; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   GLUCOSYLCERAMIDE SYNTHASE; PERSONALIZED MEDICINE; ADIPOSE-TISSUE;
   STEM-CELLS; RISK; MELLITUS; OBESITY
AB Diabetes mellitus (DM) and breast cancer (BC) can simultaneously occur in the same patient populations, but the molecular relationship between them remains unknown. In this study, we constructed genetic networks and used modularized analysis approaches to investigate the multi-dimensional characteristics of two diseases and one disease subtype. A text search engine (Agilent Literature Search 2.71) and MCODE software were applied to validate potential subnetworks and to divide the modules, respectively. A total of 793 DM-related genes, 386 type 2 diabetes (T2DM) genes and 873 BC-related genes were identified from the Online Mendelian Inheritance in Man database. For DM and BC, a total of 99 overlapping genes, 9 modules, 29 biological processes and 7 pathways were identified. Meanwhile, for T2DM and BC, 56 overlapping genes, 5 modules, 20 biological processes and 12 pathways were identified. Based on the Gene Ontology functional enrichment analysis of the top 10 non-overlapping modules of the two diseases, 10 biological functions and 5 pathways overlapped between them. The glycosphingolipid and lysosome pathways verified molecular mechanisms of cell death related to both DM and BC. We also identified new biological functions of dopamine receptors and four signalling pathways (Parkinson's disease, Alzheimer's disease, Huntington's disease and long-term depression) related to both diseases; these warrant further investigation. Our results illustrate the landscape of the novel molecular substructures between DM and BC, which may support a new model for complex disease classification and rational therapies for multiple diseases.
C1 [Zhang, Xiaoxu; Zhang, Yingying; Yu, Yanan; Liu, Jun; Wang, Zhong] China Acad Chinese Med Sci, Inst Basic Res Clin Med, Beijing 100700, Peoples R China.
   [Yuan, Ye] Nanjing Univ Chinese Med, Nanjing, Jiangsu, Peoples R China.
   [Zhao, Yijun] China Acad Chinese Med Sci, Beijing, Peoples R China.
   [Li, Haixia; Wang, Jie] China Acad Chinese Med Sci, Guanganmen Hosp, Dept Cardiol, Beijing 100700, Peoples R China.
C3 Institute of Basic Research In Clinical Medicine, CACMS; China Academy
   of Chinese Medical Sciences; Nanjing University of Chinese Medicine;
   China Academy of Chinese Medical Sciences; Guang'anmen Hospital, CACMS;
   China Academy of Chinese Medical Sciences
RP Wang, Z (corresponding author), China Acad Chinese Med Sci, Inst Basic Res Clin Med, 16 Nanxiaojie, Beijing 100700, Peoples R China.
EM zhonw@vip.sina.com
RI Yu, Yanan/LTF-2590-2024; Wang, Zhong/AAY-7574-2020; Wang,
   Jintao/HLP-4208-2023
OI Wang, Jie/0000-0001-7870-0646
CR [Anonymous], ISRN ENDOCRINOL
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NR 53
TC 3
Z9 5
U1 0
U2 11
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
EI 1582-4934
J9 J CELL MOL MED
JI J. Cell. Mol. Med.
PD MAY
PY 2015
VL 19
IS 5
BP 1094
EP 1102
DI 10.1111/jcmm.12504
PG 9
WC Cell Biology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Research & Experimental Medicine
GA CH4GE
UT WOS:000353991100018
PM 25752479
OA Green Published
DA 2025-06-11
ER

PT J
AU Sohn, M
   Benowitz, N
   Stotts, N
   Christopherson, D
   Kim, KS
   Jang, YS
   Ahn, MS
   Froelicher, ES
AF Sohn, Min
   Benowitz, Neal
   Stotts, Nancy
   Christopherson, Dianne
   Kim, Kyung Soo
   Jang, Yang Soo
   Ahn, Mi Sook
   Froelicher, Erika Sivarajan
TI Smoking behavior in men hospitalized with cardiovascular disease in
   Korea: A cross-sectional descriptive study
SO HEART & LUNG
LA English
DT Article
ID ACUTE MYOCARDIAL-INFARCTION; NONSMOKING WINS; NICOTINE DEPENDENCE;
   METABOLIC SYNDROME; CIGARETTE-SMOKING; FAGERSTROM TEST; WOMEN SMOKERS;
   CESSATION; PREVALENCE; DEPRESSION
AB OBJECTIVE: Korean men have the highest rate of smoking in the world, and cardiovascular disease (CVD) is the second leading cause of death in this Population. The study's objective was to describe factors related to smoking behavior in men hospitalized with CVD in Korea.
   METHODS: In collecting data for this cross-sectional Study, a structured questionnaire was administered using a guided interview and medical record abstraction.
   RESULTS: The Study sample included 97 men with a mean age of 54.1 (+/- 9.6) years. Most of the men were married (85.6%) and employed (79.4%), and had graduated from high school or higher levels of education (74.2%). Sixty-five percent of the men were addicted to nicotine. Lower education (odds ratio [OR]: 3.20, 95% confidence interval [CI]: 1.01-10.14), starting to smoke at an early age (OR: 3.30, 95% CI: 1.14-9.50), and smoking more cigarettes per day (OR: 9.71, 95% CI: 2.31-40.90) were statistically significant independent predictors of their level of addiction. Twenty-two percent of the men smoked during their hospitalization, a behavior that was significantly associated only with their intention to quit smoking (OR:.09, 95% CI:.03-.31).
   CONCLUSION: This was the first Study to investigate smoking behavior in men hospitalized with CVD in Korea. its findings strongly suggest that smoking-cessation intervention is needed in this Population and that Korean health care providers must be properly educated and trained to provide this service.
C1 [Sohn, Min] Calif State Univ Hayward, Dept Nursing & Hlth Sci, Hayward, CA 94542 USA.
   [Benowitz, Neal] Univ Calif San Francisco, Dept Med, San Francisco, CA USA.
   [Benowitz, Neal] Univ Calif San Francisco, Dept Psychiat, San Francisco, CA USA.
   [Benowitz, Neal] Univ Calif San Francisco, Dept Biopharmaceut Sci, San Francisco, CA USA.
   [Benowitz, Neal] San Francisco Gen Hosp, Med Ctr, Med Serv, Div Clin Pharmacol & Expt Therapeut, San Francisco, CA 94110 USA.
   [Stotts, Nancy; Christopherson, Dianne; Froelicher, Erika Sivarajan] Univ Calif San Francisco, Sch Nursing, Dept Physiol Nursing, San Francisco, CA 94143 USA.
   [Kim, Kyung Soo] Hanyang Univ, Coll Med, Div Cardiol, Seoul 133791, South Korea.
   [Jang, Yang Soo; Ahn, Mi Sook] Yonsei Univ, Dept Cardiol, Yonsei Med Ctr, Seoul 120749, South Korea.
   [Froelicher, Erika Sivarajan] Univ Calif San Francisco, Sch Med, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA.
C3 California State University System; California State University East
   Bay; University of California System; University of California San
   Francisco; University of California System; University of California San
   Francisco; University of California System; University of California San
   Francisco; San Francisco General Hospital Medical Center; University of
   California System; University of California San Francisco; Hanyang
   University; Yonsei University; University of California System;
   University of California San Francisco
RP Sohn, M (corresponding author), Calif State Univ Hayward, Dept Nursing & Hlth Sci, 25800 Carlos Bee Blvd, Hayward, CA 94542 USA.
RI Jang, Yang/D-4803-2012
OI Jang, Yangsoo/0000-0002-2169-3112; SOHN, MIN/0000-0003-4021-2051
FU Century Club Fund and Graduate Research Fund, University of California
   San Francisco
FX Funded by the Century Club Fund and Graduate Research Fund, University
   of California San Francisco.
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NR 71
TC 4
Z9 5
U1 0
U2 5
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0147-9563
EI 1527-3288
J9 HEART LUNG
JI Heart Lung
PD SEP-OCT
PY 2008
VL 37
IS 5
BP 366
EP 379
DI 10.1016/j.hrtlng.2007.11.001
PG 14
WC Cardiac & Cardiovascular Systems; Nursing; Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Cardiovascular System & Cardiology; Nursing; Respiratory System
GA 351FU
UT WOS:000259410700005
PM 18790337
DA 2025-06-11
ER

PT J
AU Tunio, YM
   Farhad, R
   Dars, AG
   Mangrio, GM
   Laghari, U
   Chachar, TS
AF Tunio, Yar Muhammad
   Farhad, Ruqayya
   Dars, Abdul Ghaffar
   Mangrio, Ghullam Mustafa
   Laghari, Ummama
   Chachar, Tarique Shahzad
TI Incidence of Erectile Dysfunction in Patients of Diabetes Mellitus
SO JOURNAL OF PHARMACEUTICAL RESEARCH INTERNATIONAL
LA English
DT Article
DE Erectile dysfunction; type 2 diabetes; glycemic control; diabetic
   patients
ID RISK-FACTORS; MEN; HYPOGONADISM; ASSOCIATION; TESTOSTERONE; PREVALENCE
AB Aim: The goal of this study was to determine how frequent erectile dysfunction is in diabetic people and what factors contribute to this condition.
   Methods: In this study, type-2 diabetes patients were selected among outpatients who visited Diabetes Clinics regularly. For the first selection of patients, it was essential to have had a diagnosis of type 2 diabetes for at least six months but no more than 10 years. 1,080 male diabetic patients (with or without active ED symptoms) who visited the institute's Medicine or Psychiatry Outpatient Departments were included in the study throughout the period under consideration. The individuals' body mass index (BMI), blood sugar levels, and lipid profile were all measured. Erectile dysfunction became more common as people became older. ED was shown to be associated with elevated hemoglobin A1c (HbA1c), as well as hypertension, atherogenic dyslipidemia (low HDL cholesterol and high triglycerides), metabolic syndrome, and depression in the study population. Male erectile dysfunction (ED) has been demonstrated to be prevented by physical activity, with men who exercised more being 10 percent less likely to develop ED than those who did not.
   Results: Erectile dysfunction was shown to be prevalent in 32.21 percent of men. Patients with erectile dysfunction had a substantially higher mean age (58.4010.96 years) than those who did not have erectile dysfunction (51.0011.16 years) (p0.001).
   Conclusion: In conclusion, glycemic control and other metabolic variables were linked to ED risk in people with type 2 diabetes, having a greater degree of physical activity was protective.
C1 [Tunio, Yar Muhammad; Farhad, Ruqayya] GAMBAT, GAMBAT Inst Med Sci, Dept Med, Khairpur, Pakistan.
   [Dars, Abdul Ghaffar; Mangrio, Ghullam Mustafa] Liaquat Univ Med & Hlth Sci, Dept Med, Jamshoro, Pakistan.
   [Laghari, Ummama] United Med & Dent Coll, Karachi, Pakistan.
   [Chachar, Tarique Shahzad] Mohammad Bin Khalifa Bin Salman Al Khalifa Specia, Dept Cardiol, Awali, Bahrain.
C3 Liaquat University of Medical & Health Sciences
RP Tunio, YM (corresponding author), GAMBAT, GAMBAT Inst Med Sci, Dept Med, Khairpur, Pakistan.
EM niaz_h@hotmail.com
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NR 23
TC 0
Z9 0
U1 0
U2 4
PU SCIENCEDOMAIN INT
PI GURGAON
PA SCIENCEDOMAIN INT, GURGAON, 00000, INDIA
SN 2456-9119
J9 J PHARM RES INT
JI J. Pharm. Res. Int.
PY 2021
VL 33
IS 57A
BP 6
EP 12
AR 78397
DI 10.9734/JPRI/2021/v33i57A33962
PG 7
WC Pharmacology & Pharmacy
WE Emerging Sources Citation Index (ESCI)
SC Pharmacology & Pharmacy
GA XV4LL
UT WOS:000734915200002
OA gold
DA 2025-06-11
ER

PT J
AU Culha, MG
   Canat, L
   Degirmentepe, RB
   Albayrak, AT
   Atalay, HA
   Merder, E
   Ariman, A
   Altunrende, F
AF Culha, Mehmet Gokhan
   Canat, Lutfi
   Degirmentepe, Recep Burak
   Albayrak, Ahmet Tevfik
   Atalay, Hasan Anil
   Merder, Erkan
   Ariman, Ahmet
   Altunrende, Fatih
TI The correlation between atherogenic indexes and erectile dysfunction
SO AGING MALE
LA English
DT Article
DE Atherosclerosis; atherogenic index; Castelli's risk index; erectile
   dysfunction
ID CORONARY-ARTERY-DISEASE; INTERNATIONAL INDEX; METABOLIC SYNDROME;
   CARDIOVASCULAR RISK; PLASMA; ATHEROSCLEROSIS; CHOLESTEROL; PREVALENCE;
   DEPRESSION
AB Aside from the ordinary plasma lipid level measurements, the ratios based on individual plasma lipid levels such as atherogenic index of plasma (AIP), Castelli's risk index 1/2 (CRI-1/2), and atherogenic coefficient (AC) are the novel parameters to evaluate the patients with a high risk of CVD. In this study, we aim to evaluate the relationship between AIP, AC, and CRI-1/2 with increased risk of ED. Between April 2018 and February 2019, 253 patients, who were diagnosed as a vasculogenic ED in our clinic, were enrolled in the study. While the first group (n = 134) consisted of patients with moderate and mild ED (IIEF-EF: 17-30), the second group (n = 119) consisted of patients with severe ED. In addition to the mean values of lipid parameters; CRI-1 (total cholesterol/HDL), CRI-2 (LDL/HDL) AIP (log10(triglycerides/HDL), and AC (non-HDL/HDL) were calculated. The mean age was 44.02 +/- 10.41 (24-70), and the mean BMI was 27.80 +/- 4.12 (18.52 +/- 41.97). However, CRI-1 and AIP values were found to be higher in the severe ED group compared to the mild ED group (CRI-1: 4.50 +/- 1.47, 4.88 +/- 1.30; p = .039; AIP: 0.489 +/- 0.315, 0.617 +/- 0.283; p = .007). Our results demonstrated that CR-1 and AIP have a positive correlation with the severity of ED. Moreover, we can suggest that patients with higher CR-1 and AIP values are likely to have more severe ED in the future.
C1 [Culha, Mehmet Gokhan; Canat, Lutfi; Degirmentepe, Recep Burak; Atalay, Hasan Anil; Merder, Erkan; Ariman, Ahmet; Altunrende, Fatih] Univ Hlth Sci, Okmeydani Training & Res Hosp, Dept Urol, Darulaceze Cad 25, TR-34371 Istanbul, Turkey.
   [Albayrak, Ahmet Tevfik] Univ Hlth Sci, Sisli Hamidiye Etfal Training & Res Hosp, Dept Urol, Istanbul, Turkey.
C3 Istanbul Okmeydani Training & Research Hospital; Istanbul Sisli Hamidiye
   Etfal Training & Research Hospital; University of Health Sciences Turkey
RP Culha, MG (corresponding author), Univ Hlth Sci, Okmeydani Training & Res Hosp, Dept Urol, Darulaceze Cad 25, TR-34371 Istanbul, Turkey.
EM gokhan_culha64@hotmail.com
RI canat, halil lutfi/GQA-5980-2022; , gokhanculha/AAL-8393-2020; ATALAY,
   Hasan/O-6795-2018; Degirmentepe, Recep Burak/LDF-7747-2024; Albayrak,
   Ahmet Tevfik/W-9108-2019
OI Degirmentepe, Recep Burak/0000-0002-2875-5750; Merder,
   Erkan/0000-0002-6325-3297; Canat, Halil Lutfi/0000-0001-6481-7907;
   Ariman, Ahmet/0000-0001-9400-2856; Albayrak, Ahmet
   Tevfik/0000-0001-9945-5686
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NR 35
TC 11
Z9 11
U1 0
U2 7
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1368-5538
EI 1473-0790
J9 AGING MALE
JI Aging Male
PD APR 9
PY 2020
VL 23
IS 5
BP 1232
EP 1236
DI 10.1080/13685538.2020.1749996
EA APR 2020
PG 5
WC Endocrinology & Metabolism; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Urology & Nephrology
GA RP6SI
UT WOS:000526267500001
PM 32266853
OA Bronze
DA 2025-06-11
ER

PT J
AU Terzano, C
   Colamesta, V
   Unim, B
   Romani, S
   Meneghini, A
   Volpe, G
   La Torre, G
AF Terzano, C.
   Colamesta, V.
   Unim, B.
   Romani, S.
   Meneghini, A.
   Volpe, G.
   La Torre, G.
TI Chronic obstructive pulmonary disease (COPD) exacerbation: impact of
   comorbidities on length and costs during hospitalization
SO EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
LA English
DT Article
DE COPD; Hospitalization; Comorbidities; Cost; Exacerbation
ID MYOCARDIAL-INFARCTION; CARDIOVASCULAR-DISEASE; GLOBAL BURDEN; SOCIAL
   IMPACT; MORTALITY; OUTCOMES; PREVALENCE; ASTHMA; SIRIO; RISK
AB OBJECTIVE: A retrospective cohort study was performed, using administrative database of the Local Health Unit Roma-A (LHU RM-A). The included subjects were residing in one of the four districts and were hospitalized for COPD exacerbation in healthcare facilities of the LHU during years 2010-2012.
   PATIENTS AND METHODS: The aim of the present study is to evaluate the impact of comorbidities, length and costs of hospital stay in patients with COPD exacerbations. Chronic obstructive pulmonary disease (COPD) is often associated with other diseases (cardiovascular diseases, diabetes, metabolic syndrome, chronic renal failure, depression) that can increase risk of mortality and hospitalization.
   RESULTS: A total of 1890 COPD patients are included in the study. The mean length of hospitalization is 12.25 days (SD +/- 10.91), 11.63 days (SD +/- 9.76) and 11.91 days (SD +/- 9.69) with a mean cost of hospitalization amounting to euro 3683.48 (SD +/- 2037.12), 3356.82 (SD +/- 1674.86) and 3706.81 (SD +/- 2087.72) in 2010, 2011 and 2012 respectively. The presence and number of comorbidities are positively and significantly associated to the length and cost of hospitalization. In particular, patients with cardiovascular diseases or diabetes mellitus associated with other comorbidities present the highest values of hospital stay and cost. The cost and the length of hospitalization were significantly linked to the number of comorbidities.
   CONCLUSIONS: Comorbidities play an important role in the hospital management of COPD exacerbation, increasing health care costs related to this disease.
C1 [Terzano, C.; Romani, S.] Sapienza Univ Rome, Azienda Policlin Umberto 1, Resp Dis Unit, Rome, Italy.
   [Colamesta, V.; Unim, B.; La Torre, G.] Sapienza Univ Rome, Dept Publ Hlth & Infect Dis, Rome, Italy.
   [Meneghini, A.; Volpe, G.] RM A Local Hlth Unit, Informat Syst, Rome, Italy.
C3 Sapienza University Rome; University Hospital Sapienza Rome; Sapienza
   University Rome
RP La Torre, G (corresponding author), Sapienza Univ Rome, Dept Publ Hlth & Infect Dis, Rome, Italy.
EM giuseppe.latorre@uniroma1.it
RI Unim, Brigid/ADT-5896-2022; La Torre, Giuseppe/AAI-6866-2020
OI Unim, Brigid/0000-0002-6522-9098
CR [Anonymous], 2014, GLOB STRAT DIAGN MAN
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   Sin DD, 2006, EUR RESPIR J, V28, P1245, DOI 10.1183/09031936.00133805
   Soriano JB, 2005, CHEST, V128, P2099, DOI 10.1378/chest.128.4.2099
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   Terzano C, 2014, EUR REV MED PHARMACO, V18, P2908
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NR 32
TC 33
Z9 38
U1 1
U2 8
PU VERDUCI PUBLISHER
PI ROME
PA VIA GREGORIO VII, ROME, 186-00165, ITALY
SN 1128-3602
J9 EUR REV MED PHARMACO
JI Eur. Rev. Med. Pharmacol. Sci.
PD AUG
PY 2017
VL 21
IS 16
BP 3680
EP 3689
PG 10
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA FH9AY
UT WOS:000411499700024
PM 28925473
DA 2025-06-11
ER

PT J
AU Chen, MH
   Li, CT
   Hsu, JW
   Huang, KL
   Lin, WC
   Chang, WH
   Chen, TJ
   Pan, TL
   Su, TP
   Bai, YM
AF Chen, Mu-Hong
   Li, Cheng-Ta
   Hsu, Ju-Wei
   Huang, Kai-Lin
   Lin, Wei-Chen
   Chang, Wen-Han
   Chen, Tzeng-Ji
   Pan, Tai-Long
   Su, Tung-Ping
   Bai, Ya-Mei
TI Atopic Diseases and Subsequent Ischemic Stroke Among Patients With
   Schizophrenia: A Nationwide Longitudinal Study
SO PSYCHOSOMATIC MEDICINE
LA English
DT Article
DE atopy; schizophrenia; stroke
ID METABOLIC SYNDROME; BIPOLAR DISORDER; RELATIVE RISK; ASSOCIATION;
   ASTHMA; POLYMORPHISM; ATHEROSCLEROSIS; DEPRESSION; RESISTANCE; MORTALITY
AB Background Chronic inflammation plays an important role in schizophrenia and atopic diseases, and studies have suggested that chronic inflammation is associated with an increased risk of stroke. The role of atopic diseases in the development of stroke among patients with schizophrenia is still unknown.
   Methods A total of 63,913 patients with schizophrenia without a stroke history between 2002 and 2008 and 63,913 age- and sex-matched controls were included and followed up to the end of 2011. Patients with schizophrenia and the reference group were divided into subgroups based on the presence or absence of atopic diseases. Individuals who developed stroke during follow-up were identified.
   Results Patients with schizophrenia had an increased risk of developing ischemic stroke (no atopic disease: hazard ratio [HR] = 2.18, 95% confidence interval [CI] = 1.88-2.53; with atopic disease: HR = 3.11, 95% CI = 2.63-3.69) compared with the reference group without atopic diseases. Among patients with schizophrenia, the presence of atopic diseases increased the risk of developing ischemic stroke (HR = 1.44, 95% CI = 1.24-1.66), with a cumulative relationship between greater numbers of atopic comorbidities and a greater risk of ischemic stroke (one atopic disease: HR = 1.39, 95% CI = 1.19-1.63; two atopic comorbidities: HR = 1.48, 95% CI = 1.10-2.00; at least 3 atopic comorbidities: HR = 2.81, 95% CI = 1.55-5.12).
   Conclusions The combined presence of schizophrenia and atopic diseases is associated with an increased risk of ischemic stroke in later life compared with individuals without these conditions.
C1 [Chen, Mu-Hong; Li, Cheng-Ta; Hsu, Ju-Wei; Huang, Kai-Lin; Lin, Wei-Chen; Chang, Wen-Han; Su, Tung-Ping; Bai, Ya-Mei] Taipei Vet Gen Hosp, Dept Psychiat, Taipei, Taiwan.
   [Chen, Tzeng-Ji] Taipei Vet Gen Hosp, Dept Family Med, Taipei, Taiwan.
   [Chen, Mu-Hong; Li, Cheng-Ta; Hsu, Ju-Wei; Huang, Kai-Lin; Lin, Wei-Chen; Su, Tung-Ping; Bai, Ya-Mei] Natl Yang Ming Univ, Coll Med, Dept Psychiat, Taipei 112, Taiwan.
   [Li, Cheng-Ta; Lin, Wei-Chen; Su, Tung-Ping] Natl Yang Ming Univ, Inst Brain Sci, Taipei 112, Taiwan.
   [Chen, Tzeng-Ji] Natl Yang Ming Univ, Inst Hosp & Hlth Care Adm, Taipei 112, Taiwan.
   [Pan, Tai-Long] Chang Gung Univ, Sch Tradit Chinese Med, Taoyuan, Taiwan.
   [Pan, Tai-Long] Chang Gung Univ Sci & Technol, Res Ctr Ind Human Ecol, Taoyuan, Taiwan.
C3 Taipei Veterans General Hospital; Taipei Veterans General Hospital;
   National Yang Ming Chiao Tung University; National Yang Ming Chiao Tung
   University; National Yang Ming Chiao Tung University; Chang Gung
   University; Chang Gung University of Science & Technology
RP Bai, YM (corresponding author), Dept Psychiat, 201,Shih Pai Rd,Sec 2, Taipei 11217, Taiwan.
EM tomsu0402@gmail.com; ymbi@mail2000.com.tw
RI Huang, kailin/MIN-4136-2025; Chen, TJ/AAH-8430-2021; Chen,
   MuHong/ACJ-6131-2022; Li, Cheng-Ta/AAI-5759-2021; Chen, Po/B-9725-2009
OI Li, Cheng-Ta/0000-0002-0670-1153
FU Taipei Veterans General Hospital [V103E10-001]
FX The study was supported by a grant from Taipei Veterans General Hospital
   (V103E10-001). The authors report no conflicts of interest.
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NR 32
TC 6
Z9 6
U1 0
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0033-3174
EI 1534-7796
J9 PSYCHOSOM MED
JI Psychosom. Med.
PD NOV-DEC
PY 2015
VL 77
IS 9
BP 1031
EP 1038
DI 10.1097/PSY.0000000000000234
PG 8
WC Psychiatry; Psychology; Psychology, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry; Psychology
GA CV7ZU
UT WOS:000364497100008
PM 26444387
DA 2025-06-11
ER

PT J
AU Brambilla, F
   Samek, L
   Company, M
   Lovo, F
   Cioni, L
   Mellado, C
AF Brambilla, Francesca
   Samek, Lorenzo
   Company, Marta
   Lovo, Francesca
   Cioni, Luisa
   Mellado, Carmen
TI Multivariate therapeutic approach to binge-eating disorder: combined
   nutritional, psychological and pharmacological treatment
SO INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY
LA English
DT Article
DE binge/eating disorder; cognitive-behavioural therapy; nutrition;
   sertraline; topiramate
ID COGNITIVE-BEHAVIORAL THERAPY; DOUBLE-BLIND; METABOLIC SYNDROME;
   BULIMIA-NERVOSA; OBESE PATIENTS; SELF-HELP; FOLLOW-UP; TOPIRAMATE;
   SIBUTRAMINE; FLUOXETINE
AB Treatment for binge-eating disorder (BED) is directed towards either the physical or psychopathological impairments, and often does not cover all the alterations characterizing the disease. In 30 BED patients, we monitored the effects of three types of 6-month treatment, randomly assigned to one of the three treatment groups, each consisting of 10 patients. Group 1 received a 1700-kcal diet (21% proteins, 27% lipids, 52% carbohydrate), cognitive-behavioural therapy (CBT), sertraline (50-150 mg/day) and topiramate (25-150 mg/day); group 2 received the same diet, CBT, sertraline; and group 3 received nutritional counselling and CBT. Binge frequency and weight were assessed every month. The Eating Disorder Inventory-2, the Symptoms Check List-90-Revised (SCL-90-R) and the Personality Diagnostic Questionnaire-4-Revised (PDQ-4-R) were administered before and after treatment. Binge frequency and excessive weight decreased significantly only in group 1 patients, in whom improvement was noted in total Eating Disorder Inventory-2 scores and the subitems 'bulimia','drive for thinness', 'maturity fear, 'ascetism', in total SCL-90-R scores and in the subitem 'somatization', in PDQ-4-R subitems 'schizotypic personality' and 'dependent personality. Group 2 patients improved on the SCL-90-R subitems 'depression' and 'interpersonal relationship' and in the PDQ-4-R 'schizoid personality'. Combination therapy seems to be the only fully effective treatment in BED patients. Int Clin Psychopharmacol 24:312-317 (C) 2009 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
C1 [Brambilla, Francesca; Samek, Lorenzo; Company, Marta; Lovo, Francesca; Cioni, Luisa; Mellado, Carmen] Sacco Hosp, Dept Mental Hlth, Ctr Eating Disorders, Milan, Italy.
C3 University of Milan; Luigi Sacco Hospital
RP Brambilla, F (corresponding author), Ctr Psiconeuroendocrinol, Piazza Grandi 3, I-20129 Milan, Italy.
EM francesca.brambilla.4@tin.it
OI Brambilla, Francesca/0000-0002-5100-5691
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NR 58
TC 32
Z9 33
U1 0
U2 22
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0268-1315
EI 1473-5857
J9 INT CLIN PSYCHOPHARM
JI Int. Clin. Psychopharmacol.
PD NOV
PY 2009
VL 24
IS 6
BP 312
EP 317
DI 10.1097/YIC.0b013e32832ac828
PG 6
WC Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Pharmacology & Pharmacy; Psychiatry
GA 516RP
UT WOS:000271560400005
PM 19794312
DA 2025-06-11
ER

PT J
AU Kaminska, MS
   Schneider-Matyka, D
   Rachubinska, K
   Panczyk, M
   Grochans, E
   Cybulska, AM
AF Kaminska, Magdalena Sylwia
   Schneider-Matyka, Daria
   Rachubinska, Kamila
   Panczyk, Mariusz
   Grochans, Elzbieta
   Cybulska, Anna Maria
TI Menopause Predisposes Women to Increased Risk of Cardiovascular Disease
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Article
DE cardiovascular disease; coronary heart disease; diagnostic medicine;
   medical risk factors; menopause; women's health
ID ENDOGENOUS SEX-HORMONES; HEART-DISEASE; VASOMOTOR SYMPTOMS; NATURAL
   MENOPAUSE; BLOOD-PRESSURE; PREMENOPAUSAL; HYPERTENSION; DEPRESSION;
   EVENTS; AGE
AB (1) Background: Menopause is an important event in women's lives, possibly contributing to the development of CVD, which is associated with changes in the cardiovascular risk profile, markers of metabolic health, and subclinical atherosclerosis. The aim of this study was to assess the association of menopause with CVD risk factors and subclinical markers of cardiometabolic disease. (2) Methods: The study involved 235 women from the general population at different stages of menopause. The methods used in this study were: diagnostic survey, anthropometric measurement (WC, height, BMI, WHtR), blood pressure measurement, biochemical analysis of venous blood (lipid profile, glucose, insulin, HbA1c), and CVD risk assessment (ASCVD Risk Calculator, POL-SCORE, SCORE-2). (3) Results: The vast majority of respondents had low cardiovascular risk, irrespective of the scale used for measuring the risk of CVD. The age at menopause was not an independent risk factor for CVD. In Model 1, the age at menopause and the time since menopause were found to be factors that increased CVD risk (OR = 1.186 and 1.267, respectively). In Models 2 and 3, the severity of menopausal symptoms was not a risk factor for CVD. Models 3 and 4 demonstrated that women with metabolic syndrome (MetS) were at a significantly higher risk of CVD. In model 5, the odds ratio of CVD with MetS as a standalone factor was 13.812. (4) Conclusions: Menopause predisposes women to an increased risk and MetS to a significantly higher risk of CVD.
C1 [Kaminska, Magdalena Sylwia] Pomeranian Med Univ, Fac Hlth Sci, Dept Social Med, Subdept Long Term Care & Palliat Med, 48 Zolnierska St, PL-71210 Szczecin, Poland.
   [Schneider-Matyka, Daria; Rachubinska, Kamila; Grochans, Elzbieta; Cybulska, Anna Maria] Pomeranian Med Univ, Fac Hlth Sci, Dept Nursing, 48 Zolnierska St, PL-71210 Szczecin, Poland.
   [Panczyk, Mariusz] Med Univ Warsaw, Fac Hlth Sci, Dept Educ & Res Hlth Sci, 14-16 Litewska St, PL-00581 Warsaw, Poland.
C3 Pomeranian Medical University; Pomeranian Medical University; Medical
   University of Warsaw
RP Cybulska, AM (corresponding author), Pomeranian Med Univ, Fac Hlth Sci, Dept Nursing, 48 Zolnierska St, PL-71210 Szczecin, Poland.
EM anna.cybulska@pum.edu.pl
RI Cybulska, Anna/AAV-5966-2020; Grochans, Elżbieta/K-8659-2014;
   Rachubińska, Kamila/T-7984-2019; Grochans, Elzbieta/M-1593-2014;
   Panczyk, Mariusz/B-4412-2011; Kaminska, Magdalena/O-7349-2014
OI Grochans, Elzbieta/0000-0002-3679-7002; Panczyk,
   Mariusz/0000-0003-1830-2114; Rachubinska, Kamila/0000-0003-2200-3766;
   Kaminska, Magdalena/0000-0003-4795-033X; Cybulska, Anna
   Maria/0000-0002-6912-287X
FU Pomeranian Medical University in Szczecin, Poland
FX No Statement Available
CR acc, ASCVD RISK ESTIMATOR
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NR 63
TC 22
Z9 22
U1 2
U2 5
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD NOV
PY 2023
VL 12
IS 22
AR 7058
DI 10.3390/jcm12227058
PG 18
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA AU0B6
UT WOS:001120839400001
PM 38002671
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Batinic, B
   Ristic, I
   Zugic, M
   Baldwin, DS
AF Batinic, Borjanka
   Ristic, Ivan
   Zugic, Milica
   Baldwin, David S.
TI Treatment of Symptom Clusters in Schizophrenia, Bipolar Disorder and
   Major Depressive Disorder With the Dopamine D3/D2 Preferring Partial
   Agonist Cariprazine
SO FRONTIERS IN PSYCHIATRY
LA English
DT Review
DE cariprazine; D3; D2 partial agonist; schizophrenia; bipolar I disorder;
   major depressive disorder
ID POST-HOC ANALYSES; QUALITY-OF-LIFE; DOUBLE-BLIND; NEGATIVE SYMPTOMS; I
   DISORDER; ACUTE EXACERBATION; MIXED FEATURES; ACUTE MANIA; PHASE-II;
   EFFICACY
AB Cariprazine is currently approved for the treatment of patients with schizophrenia (USA and EU), and for manic, depressive, and episodes with mixed features in bipolar I disorder (USA): several randomized controlled studies have also explored its efficacy in patients with major depressive disorder. This review summarizes its current therapeutic uses and potential advantages for treating the main symptoms of schizophrenia, bipolar I and major depressive disorder, considering its pharmacodynamic properties, efficacy, and tolerability. Its predominantly D3 receptor preferring affinity, with functional selectivity according to the prevailing neuronal environment, contributes to its efficacy across a wide array of psychopathological symptoms (including reality distortion, disorganized thought, negative symptoms, mood disturbance, anhedonia, and cognitive impairment), and to a favorable side effect profile. Cariprazine may be a "drug of choice" in patients with predominant negative and cognitive symptoms of schizophrenia, as well as those with metabolic syndrome. Further investigation of its relative efficacy when compared to aripiprazole or other active comparators is warranted. Its effectiveness in the treatment of bipolar mania, bipolar I depression and bipolar I episodes with mixed features, with minimal accompanying metabolic changes is well-established. The longer half-life and delayed time to relapse in patients diagnosed with schizophrenia when compared to other second-generation antipsychotics represent other advantages, given the high rates of non-adherence and frequent relapses seen in clinical practice. Its efficacy in overlapping symptom domains in other major psychiatric disorders appears promising.
C1 [Batinic, Borjanka] Univ Clin Ctr Serbia, Clin Psychiat, Belgrade, Serbia.
   [Batinic, Borjanka] Univ Belgrade, Fac Philosophy, Dept Psychol, Belgrade, Serbia.
   [Ristic, Ivan] Univ Belgrade, Med Sch, Dept Epidemiol, Belgrade, Serbia.
   [Ristic, Ivan; Zugic, Milica] Inst Mental Hlth, Dept Psychiat, Belgrade, Serbia.
   [Baldwin, David S.] Univ Southampton, Fac Med, Clin & Expt Sci CNS & Psychiat, Southampton, Hants, England.
   [Baldwin, David S.] Univ Cape Town, Dept Psychiat & Mental Hlth, Cape Town, South Africa.
C3 Clinical Centre of Serbia; University of Belgrade; University of
   Belgrade; University of Southampton; University of Cape Town
RP Batinic, B (corresponding author), Univ Clin Ctr Serbia, Clin Psychiat, Belgrade, Serbia.; Batinic, B (corresponding author), Univ Belgrade, Fac Philosophy, Dept Psychol, Belgrade, Serbia.
EM doubleb@eunet.rs
RI Batinic, Borjanka/AAH-2091-2020
OI Batinic, Borjanka/0000-0002-3902-1031
CR Alamo C., 2013, Clinical and Experimental Pharmacology, V3, P117
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NR 85
TC 9
Z9 9
U1 2
U2 6
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-0640
J9 FRONT PSYCHIATRY
JI Front. Psychiatry
PD NOV 23
PY 2021
VL 12
AR 784370
DI 10.3389/fpsyt.2021.784370
PG 8
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA XK7KP
UT WOS:000727640000001
PM 34887792
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Portugal-Nunes, C
   Castanho, TC
   Moreira, PS
   Magalhaes, R
   Marques, P
   Costa, P
   Palha, JA
   Sousa, N
   Santos, NC
   Bessa, JM
AF Portugal-Nunes, Carlos
   Castanho, Teresa Costa
   Moreira, Pedro Silva
   Magalhaes, Ricardo
   Marques, Paulo
   Costa, Patricio
   Palha, Joana Almeida
   Sousa, Nuno
   Santos, Nadine Correia
   Bessa, Joao Miguel
TI The moderator effect of age in the association between mood and
   adiposity in the elderly is specific for the subcutaneous adipose
   compartment: An MRI study
SO INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
LA English
DT Article
DE age; magnetic resonance; mood disorders; subcutaneous adipose tissue;
   visceral fat
ID BODY-MASS INDEX; ABDOMINAL FAT DISTRIBUTION; DEPRESSIVE SYMPTOMS;
   OLDER-ADULTS; METABOLIC SYNDROME; OBESITY; METAANALYSIS; OVERWEIGHT;
   POPULATION; WOMEN
AB Objectives
   The positive association between obesity and depressive mood in young- and middle-age individuals is a phenomenon with major clinical implications in public health. Interestingly, the trend of this association in older individuals is not clear, given the conflicting results of multiple studies. Since aging is accompanied by changes in body fat distribution, we questioned whether age is a modulator of such association. This study explores the role of age in the association between mood and general (body mass index [BMI]) and abdominal adiposity (waist circumference [WC]) in older adults characterizing the different abdominal adipose tissue compartments (subcutaneous adipose tissue [SAT] and visceral adipose tissue [VAT]) with magnetic resonance imaging (MRI) techniques.
   Methods One hundred twenty aged community-dwelling individuals (>= 50 y of age) were assessed regarding depressive mood (Geriatric Depression Scale) and adiposity (BMI and WC). From these, 96 were assessed for SAT and VAT using MRI.
   Results Using multiple linear regression models, depressive mood was positively associated with BMI, WC, and VAT. Age was a significant moderator of the association between depressive mood and BMI, WC, and SAT: positive in younger participants and null or negative in older participants. On the other hand, higher VAT was significantly associated with a more depressive mood, independently of age.
   Conclusions This study identifies age as a relevant moderator in the association between depressive mood and adiposity in the elderlies. Furthermore, the body fat compartment analysis revealed that the effect of age is specific for the SAT, suggesting its protective role in depressive mood.
C1 [Portugal-Nunes, Carlos; Castanho, Teresa Costa; Moreira, Pedro Silva; Magalhaes, Ricardo; Marques, Paulo; Costa, Patricio; Palha, Joana Almeida; Sousa, Nuno; Santos, Nadine Correia; Bessa, Joao Miguel] Univ Minho, Sch Med, Life & Hlth Sci Res Inst ICVS, Campus Gualtar, P-4710057 Braga, Portugal.
   [Portugal-Nunes, Carlos; Castanho, Teresa Costa; Moreira, Pedro Silva; Magalhaes, Ricardo; Marques, Paulo; Costa, Patricio; Palha, Joana Almeida; Sousa, Nuno; Santos, Nadine Correia; Bessa, Joao Miguel] ICVS 3Bs, PT Govt Associate Lab, Braga, Portugal.
   [Portugal-Nunes, Carlos; Castanho, Teresa Costa; Moreira, Pedro Silva; Magalhaes, Ricardo; Marques, Paulo; Costa, Patricio; Palha, Joana Almeida; Sousa, Nuno; Santos, Nadine Correia; Bessa, Joao Miguel] Clin Acad Ctr Braga, Braga, Portugal.
C3 Universidade do Minho; Laboratorio Associado ICVS 3B's
RP Bessa, JM (corresponding author), Univ Minho, Sch Med, Life & Hlth Sci Res Inst ICVS, Campus Gualtar, P-4710057 Braga, Portugal.
EM joaobessa@med.uminho.pt
RI Moreira, Pedro/E-4471-2018; Costa, Patricio/A-3072-2013; Silva Moreira,
   Pedro/D-7895-2016; Portugal-Nunes, Carlos/AGW-4051-2022; Magalhaes,
   Ricardo/Q-7995-2018; Palha, Joana/C-2745-2009; Castanho,
   Teresa/T-5279-2018; Bessa, Joao/K-8079-2014; Sousa, Nuno/N-9137-2017;
   Correia Santos, Nadine/K-7431-2015
OI Costa, Patricio/0000-0002-1201-9177; Silva Moreira,
   Pedro/0000-0002-2800-3903; Portugal-Nunes, Carlos/0000-0001-8398-1366;
   Magalhaes, Ricardo/0000-0001-6279-2195; Palha,
   Joana/0000-0002-8866-368X; Castanho, Teresa/0000-0002-4162-0359; Bessa,
   Joao/0000-0001-6385-2452; Sousa, Nuno/0000-0002-8755-5126; Correia
   Santos, Nadine/0000-0001-8110-7173
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NR 65
TC 5
Z9 5
U1 0
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0885-6230
EI 1099-1166
J9 INT J GERIATR PSYCH
JI Int. J. Geriatr. Psychiatr.
PD JAN
PY 2020
VL 35
IS 1
BP 113
EP 121
DI 10.1002/gps.5226
PG 9
WC Geriatrics & Gerontology; Gerontology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Psychiatry
GA QF1KN
UT WOS:000616658100012
PM 31657069
DA 2025-06-11
ER

PT J
AU Minami, T
   Tachikawa, R
   Matsumoto, T
   Murase, K
   Tanizawa, K
   Inouchi, M
   Handa, T
   Oga, T
   Hirai, T
   Chin, K
AF Minami, Takuma
   Tachikawa, Ryo
   Matsumoto, Takeshi
   Murase, Kimihiko
   Tanizawa, Kiminobu
   Inouchi, Morito
   Handa, Tomohiro
   Oga, Toru
   Hirai, Toyohiro
   Chin, Kazuo
TI Adrenal gland size in obstructive sleep apnea: Morphological assessment
   of hypothalamic pituitary adrenal axis activity
SO PLOS ONE
LA English
DT Article
ID SYMPATHETIC-NERVOUS-SYSTEM; METABOLIC SYNDROME; MAJOR DEPRESSION;
   VISCERAL FAT; CORTISOL; VOLUME; CT; CATECHOLAMINES; ASSOCIATIONS;
   POPULATION
AB Objectives
   The association of obstructive sleep apnea (OSA) with hypothalamic pituitary adrenal (HPA) axis activation has not been fully understood from results of previous studies using hormonal assessments. We aimed to investigate the relationship between adrenal size, a potential marker reflecting HPA axis activity, and sleep parameters related to OSA.
   Methods
   We retrospectively reviewed data on 284 consecutive adult patients aged 20 to 80 y who had undergone polysomnography and abdominal computed tomography (CT). OSA was defined as none/mild (apnea-hypopnea index [AHI] < 15, n = 75), moderate (AHI 15 to 30, n = 80), and severe OSA (AHI >= 30, n = 129). Widths of adrenal body and limbs were measured by abdominal CT.
   Results
   Adrenal size was greater in participants with severe OSA than in those with none/mild or moderate OSA (adrenal body width: 6.03 mm, none/mild OSA; 6.09 mm, moderate OSA; 6.78 mm, severe OSA; p < 0.001; adrenal limb width: 3.75 mm, none/mild OSA; 3.95 mm, moderate OSA; 4.26 mm, severe OSA, p < 0.001). Multivariate regression analysis showed that not the 3% oxygen desaturation index and time of SpO(2) < 90% but a higher arousal index was the only determinant factor for increased adrenal limb width (beta = 0.27, p < 0.001) after adjusting for other variables that could affect adrenal size. Neither the arousal index nor hypoxic parameters were associated with adrenal body width.
   Conclusions
   Results indicated that adrenal glands may enlarge in response to long-standing sleep fragmentation, suggesting the involvement of OSA in HPA axis augmentation.
C1 [Minami, Takuma; Tachikawa, Ryo; Matsumoto, Takeshi; Handa, Tomohiro; Hirai, Toyohiro] Kyoto Univ, Grad Sch Med, Dept Resp Med, Kyoto, Japan.
   [Murase, Kimihiko; Tanizawa, Kiminobu; Inouchi, Morito; Chin, Kazuo] Kyoto Univ, Grad Sch Med, Dept Resp Care & Sleep Control Med, Kyoto, Japan.
   [Oga, Toru] Kawasaki Med Sch, Dept Resp Med, Kurashiki, Okayama, Japan.
C3 Kyoto University; Kyoto University; Kawasaki Medical School
RP Chin, K (corresponding author), Kyoto Univ, Grad Sch Med, Dept Resp Care & Sleep Control Med, Kyoto, Japan.
EM chink@kuhp.kyoto-u.ac.jp
RI Tanizawa, Kiminobu/GPC-4728-2022; Matsumoto, Takeshi/AAR-4323-2020
OI Tanizawa, Kiminobu/0000-0002-5719-0744; Minami,
   Takuma/0000-0001-7353-1142
FU Japanese Ministry of Education, Culture, Sports, Science and Technology
   [26293198, 17H04182]; Intractable Respiratory Diseases and Pulmonary
   Hypertension Research Group; Ministry of Health, Labor and Welfare in
   Japan [H29-intractable diseases-general-027]; Research Foundation for
   Healthy Aging, Health, Labour and Welfare Sciences Research Grants;
   Research on Region Medical from the Ministry of Health, Labor and
   Welfare of Japan [H28-iryo-ippan-016, H30-iryo-ippan-009]; Japan Agency
   for Medical Research and Development [JP18ek0210096]
FX This work was supported in part by grants from the Japanese Ministry of
   Education, Culture, Sports, Science and Technology (26293198, 17H04182),
   the Intractable Respiratory Diseases and Pulmonary Hypertension Research
   Group, the Ministry of Health, Labor and Welfare in Japan
   (H29-intractable diseases-general-027), the Research Foundation for
   Healthy Aging, Health, Labour and Welfare Sciences Research Grants,
   Research on Region Medical from the Ministry of Health, Labor and
   Welfare of Japan (H28-iryo-ippan-016, H30-iryo-ippan-009), and Japan
   Agency for Medical Research and Development under Grant Number
   JP18ek0210096. The funders had no role in study design, data collection
   and analysis, decision to publish, or preparation of the manuscript.
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NR 52
TC 7
Z9 8
U1 0
U2 5
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD SEP 20
PY 2019
VL 14
IS 9
AR e0222592
DI 10.1371/journal.pone.0222592
PG 15
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA LM5OJ
UT WOS:000532297900018
PM 31539392
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Rastrelli, G
   Corona, G
   Bandini, E
   Strada, C
   Maseroli, E
   Ricca, V
   Faravelli, C
   Mannucci, E
   Maggi, M
AF Rastrelli, G.
   Corona, G.
   Bandini, E.
   Strada, C.
   Maseroli, E.
   Ricca, V.
   Faravelli, C.
   Mannucci, E.
   Maggi, M.
TI Investigation on psychological symptoms improves ANDROTEST accuracy in
   predicting hypogonadism in subjects with sexual dysfunction
SO INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH
LA English
DT Article
DE accuracy; hypogonadism; psychological symptoms; sensitivity; specificity
ID LATE-ONSET HYPOGONADISM; ERECTILE DYSFUNCTION; ANDROGEN DEFICIENCY;
   ELDERLY-MEN; OLDER MEN; METABOLIC SYNDROME; AGING MALES; TESTOSTERONE;
   DEPRESSION; ENDOCRINE
AB The role of psychological symptoms in recognizing late-onset hypogonadism (LOH) is still controversial. The aim of the study is to evaluate the association between LOH and specific psychological symptoms, and to verify whether investigating intra-psychic domain improves the accuracy of a validated case-history tool (ANDROTEST) in detecting LOH. A consecutive series of 1009 subjects (mean age 49.23 +/- 13.34) consulting for sexual dysfunction was studied. Intra-psychic symptoms were investigated by Middlesex Hospital Questionnaire (MHQ), a self-reported questionnaire for screening of mental disorders. A minimum set of two MHQ items was identified through iterative receiver-operating characteristic analysis, with assessment of sensitivity and specificity for hypogonadism (calculated free testosterone < 0.225 nmol l(-1)) in an exploratory sample of 462 patients. Sensitivity and specificity were verified in a validation sample of 547 subjects, in which the final two-item version showed an accuracy of 58.4 +/- 3.2% in detecting hypogonadism. The combination of the two-item score with ANDROTEST increased the accuracy in predicting hypogonadism (0.741 +/- 0.029; P < 0.0001) when compared with ANDROTEST (0.696 +/- 0.018; P < 0.0001) and the two-item score (P < 0.05) alone. Hence, combining these two psychological symptoms with a physical scoring system improves its ability in detecting hypogonadism. The combination of the scores should be tested in other studies. International Journal of Impotence Research (2013) 25, 34-39; doi:10.1038/ijir.2012.33; published online 20 September 2012
C1 [Rastrelli, G.; Bandini, E.; Maseroli, E.; Maggi, M.] Univ Florence, Dept Clin Physiopathol, Sexual Med & Androl Unit, I-50139 Florence, Italy.
   [Corona, G.] Maggiore Bellaria Hosp, Dept Clin Physiopathol, Sexual Med & Androl Unit, Bologna, Italy.
   [Corona, G.] Maggiore Bellaria Hosp, Endocrinol Unit, Bologna, Italy.
   [Strada, C.; Faravelli, C.] Univ Florence, Dept Psychol, I-50139 Florence, Italy.
   [Ricca, V.] Univ Florence, Dept Neuropsychiat Sci, Psychiat Unit, I-50139 Florence, Italy.
   [Mannucci, E.] Univ Florence, Diabet Sect, Geriatr Unit, Dept Crit Care, I-50139 Florence, Italy.
C3 University of Florence; AUSL di Bologna; AUSL di Bologna; University of
   Florence; University of Florence; University of Florence
RP Maggi, M (corresponding author), Univ Florence, Dept Clin Physiopathol, Sexual Med & Androl Unit, Viale Pieraccini 6, I-50139 Florence, Italy.
EM m.maggi@dfc.unifi.it
RI Maggi, Mario/AAB-8284-2019; Maseroli, Elisa/AAA-9745-2020; ricca,
   valdo/K-8382-2012; Mannucci, Edoardo/K-6749-2016
OI ricca, valdo/0000-0002-9291-2124; Mannucci, Edoardo/0000-0001-9759-9408;
   Rastrelli, Giulia/0000-0002-6164-4278; MAGGI, Mario/0000-0003-3267-4221
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NR 50
TC 7
Z9 7
U1 0
U2 3
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0955-9930
J9 INT J IMPOT RES
JI Int. J. Impot. Res.
PD JAN-FEB
PY 2013
VL 25
IS 1
BP 34
EP 39
DI 10.1038/ijir.2012.33
PG 6
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 072ZO
UT WOS:000313713100007
PM 22992755
DA 2025-06-11
ER

PT J
AU Douyon, L
   Schteingart, DE
AF Douyon, L
   Schteingart, DE
TI Effect of obesity and starvation on thyroid hormone, growth hormone, and
   cortisol secretion
SO ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA
LA English
DT Article
ID PITUITARY-ADRENAL AXIS; CORTICOTROPIN-RELEASING HORMONE; BODY-FAT
   DISTRIBUTION; ANOREXIA-NERVOSA; BETA-ENDORPHIN; WEIGHT-LOSS;
   PREMENOPAUSAL WOMEN; ENERGY-EXPENDITURE; METABOLISM; MEN
AB Obesity and starvation have opposing effects on normal physiology and are associated with adaptive changes in hormone secretion. Although hypothyroidism is associated with some weight gain, less than 10% of obese people are hypothyroid (thyroid function is normal). Treatment of obesity with severely hypocaloric diets causes changes in thyroid function that resemble sick euthyroid syndrome. Untreated obesity also is associated with low growth hormone (GH) levels. Levels of insulin-like growth factor 1 (IGF-1), however, are normal. These changes are reversed by drastic weight reduction. Cortisol levels are abnormal in people with abdominal obesity who exhibit an increase in urinary free cortisol but normal or decreased serum cortisol and normal adrenocorticotropic hormone (ACTH) levels. This increase in cortisol secretion may contribute to metabolic syndrome (insulin resistance, glucose intolerance, dyslipidemia, and hypertension). States of chronic starvation such as anorexia nervosa (AN) also are associated with changes in thyroid hormone, growth hormone, and cortisol secretion. Thyroid changes are consistent with findings in sick euthyroid syndrome. There is an increase in GH secretion, with a decrease in IGF-1 levels, and the changes in cortisol secretion resemble depression with increased urinary free cortisol and serum cortisol levels, but without changes in ACTH levels. The endocrine changes observed in obesity and starvation may complicate the diagnosis of primary endocrine diseases. The increase in cortisol secretion in obesity needs to be distinguished from Cushing's syndrome; the decrease in thryoid hormone levels in AN needs to be distinguished from secondary hypothyroidism; and the increase in cortisol secretion observed in AN requires a differential diagnosis with primary depressive disorder.
C1 Univ Michigan, Sch Med, Dept Internal Med, Div Endocrinol & Metab, Ann Arbor, MI 48109 USA.
C3 University of Michigan System; University of Michigan
RP Univ Michigan, Sch Med, Dept Internal Med, Div Endocrinol & Metab, 1150 W Med Ctr Dr, Ann Arbor, MI 48109 USA.
EM dschtein@med.umich.edu
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NR 76
TC 173
Z9 197
U1 1
U2 44
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0889-8529
EI 1558-4410
J9 ENDOCRIN METAB CLIN
JI Endocrinol. Metabol. Clin. North Amer.
PD MAR
PY 2002
VL 31
IS 1
BP 173
EP +
AR PII S0889-8529(01)00023-8
DI 10.1016/S0889-8529(01)00023-8
PG 18
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 557RX
UT WOS:000175922900011
PM 12055988
DA 2025-06-11
ER

PT J
AU Xiong, JF
   Wang, L
   Yang, CX
   Huang, HY
   He, B
   Shen, L
   Su, F
AF Xiong, Jianfei
   Wang, Li
   Yang, Chuanxi
   Huang, Hengye
   He, Ben
   Shen, Lan
   Su, Feng
TI Age-specific differences in hypertension combination management and
   associated factors influencing treatment choice
SO JOURNAL OF CLINICAL HYPERTENSION
LA English
DT Article
DE age; combination therapy; hypertension; influential factors
ID HIGH BLOOD-PRESSURE; ADULTS; DEPRESSION; THERAPY
AB The current hypertension guideline emphasizes combination therapy, especially single-pill combination therapy (SPC). However, few studies compared the prevalence and factors associated with initial therapy choice across heterogeneous age groups in a current population. First, the authors consecutively identified 964 treatment naive hypertensive patients in a large academic hospital from 01/31/2019 to 01/31/2020. All patients were grouped into (1) young aged, age < 55; (2) middle-aged, 55 <= age < 65; and (3) older aged, age >= 65. The multivariable regression model examined the factors associated with the combination therapy by age group. Overall, 80 (8.3%) were young, 191 (19.8%) were middle, and 693 (71.9%) were older aged. Compared with older age, younger patients were more likely to be male, highly educated, regularly exercised, have metabolic syndrome, and less likely to have cardiovascular-related comorbidities, with a lower systolic but higher diastolic pressure. Only one in five patients used SPC, and the prevalence decreased with age. Besides hypertension grade, young patients without catheterization or echo test were less likely to receive multiple therapies, while older patients who were male with lower weight and lower risk levels were less likely to receive multiple therapies. In conclusion, combination therapy, especially SPC, was underused in the targeted hypertensive population. Our contemporary population study showed that young patients (<55) without a history of catheterization or echo examination and male older-aged (>= 65) patients with low-risk classification were the population most likely to be neglected. Such information can help triage medical care resources in improving SPC use.
C1 [Xiong, Jianfei] Shanghai Jiao Tong Univ, Renji Hosp, Dept Emergency Med, Sch Med, Shanghai, Peoples R China.
   [Wang, Li] Shanghai Jiao Tong Univ, Renji Hosp, Sch Med, Dept Gen Practice, Shanghai, Peoples R China.
   [Yang, Chuanxi; Su, Feng] Tongji Univ, Shanghai Yangpu Hosp, Dept Cardiol, Shanghai, Peoples R China.
   [Huang, Hengye] Shanghai Jiao Tong Univ, Sch Publ Hlth, Sch Med, Shanghai, Peoples R China.
   [He, Ben; Shen, Lan] Shanghai Jiao Tong Univ, Shanghai Chest Hosp, Sch Med, Dept Cardiol, Shanghai, Peoples R China.
   [Shen, Lan] Shanghai Jiao Tong Univ, Shanghai Chest Hosp, Dept Cardiol, 241 Huaihai West Rd, Shanghai 200030, Peoples R China.
C3 Shanghai Jiao Tong University; Shanghai Jiao Tong University; Tongji
   University; Shanghai Jiao Tong University; Shanghai Jiao Tong
   University; Shanghai Jiao Tong University
RP Su, F (corresponding author), Tongji Univ, Shanghai Yangpu Hosp, Dept Cardiol, Shanghai, Peoples R China.; Shen, L (corresponding author), Shanghai Jiao Tong Univ, Shanghai Chest Hosp, Dept Cardiol, 241 Huaihai West Rd, Shanghai 200030, Peoples R China.
EM shenlan_shanghai@163.com; sufenga@163.com
RI Yang, Xulin/O-2253-2014
OI Yang, Chuanxi/0000-0002-6970-1214
FU National Natural Science Foundation of China [81900308]; Youth Program
   of National Natural Science Foundation of China [82200379];
   Informatization Development Project of Shanghai Municipal Commission of
   Economy and Informatization [202002009]
FX ACKNOWLEDGMENTS This research was supported by the National Natural
   Science Foundation of China to L. Shen (81900308), Youth Program of
   National Natural Science Foundation of China to C.X. Yang (82200379) and
   the Informatization Development Project of Shanghai Municipal Commission
   of Economy and Informatization (202002009).
CR [Anonymous], 2022, JAMA, V288, P2981, DOI [10.1001/jama, 10.1001/jama.288.23.2981, DOI 10.1001/JAMA.288.23.2981]
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NR 24
TC 0
Z9 0
U1 1
U2 10
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1524-6175
EI 1751-7176
J9 J CLIN HYPERTENS
JI J. Clin. Hypertens.
PD JUN
PY 2023
VL 25
IS 6
BP 545
EP 554
DI 10.1111/jch.14668
EA MAY 2023
PG 10
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA I4JS5
UT WOS:000988877800001
PM 37196052
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Lobo, RA
   Davis, SR
   De Villiers, TJ
   Gompel, A
   Henderson, VW
   Hodis, HN
   Lumsden, MA
   Mack, WJ
   Shapiro, S
   Baber, RJ
AF Lobo, R. A.
   Davis, S. R.
   De Villiers, T. J.
   Gompel, A.
   Henderson, V. W.
   Hodis, H. N.
   Lumsden, M. A.
   Mack, W. J.
   Shapiro, S.
   Baber, R. J.
TI Prevention of diseases after menopause
SO CLIMACTERIC
LA English
DT Article
DE PREVENTION; MENOPAUSE; OBESITY; CARDIOVASCULAR; OSTEOPOROSIS; COGNITION;
   DEMENTIA; CANCER; HORMONAL THERAPY
ID CORONARY-HEART-DISEASE; HORMONE REPLACEMENT THERAPY; BODY-MASS INDEX;
   OSTEOPOROSIS-RELATED FRACTURES; CARDIOVASCULAR RISK-FACTORS; CONJUGATED
   EQUINE ESTROGEN; BREAST-CANCER INCIDENCE; POSTMENOPAUSAL WOMEN;
   ALZHEIMERS-DISEASE; WAIST CIRCUMFERENCE
AB Women may expect to spend more than a third of their lives after menopause. Beginning in the sixth decade, many chronic diseases will begin to emerge, which will affect both the quality and quantity of a woman's life. Thus, the onset of menopause heralds an opportunity for prevention strategies to improve the quality of life and enhance longevity. Obesity, metabolic syndrome and diabetes, cardiovascular disease, osteoporosis and osteoarthritis, cognitive decline, dementia and depression, and cancer are the major diseases of concern. Prevention strategies at menopause have to begin with screening and careful assessment for risk factors, which should also include molecular and genetic diagnostics, as these become available. Identification of certain risks will then allow directed therapy. Evidence-based prevention for the diseases noted above include lifestyle management, cessation of smoking, curtailing excessive alcohol consumption, a healthy diet and moderate exercise, as well as mentally stimulating activities. Although the most recent publications from the follow-up studies of the Women's Health Initiative do not recommend menopause hormonal therapy as a prevention strategy, these conclusions may not be fully valid for midlife women, on the basis of the existing data. For healthy women aged 50-59 years, estrogen therapy decreases coronary heart disease and all-cause mortality; this interpretation is entirely consistent with results from other randomized, controlled trials and observational studies. Thus. as part of a comprehensive strategy to prevent chronic disease after menopause, menopausal hormone therapy, particularly estrogen therapy may be considered as part of the armamentarium.
C1 [Lobo, R. A.] Columbia Univ, Dept Obstet & Gynecol, New York, NY 10027 USA.
   [Davis, S. R.] Monash Univ, Sch Publ Hlth & Prevent Med, Melbourne, Vic 3004, Australia.
   [De Villiers, T. J.] Univ Stellenbosch, Fac Hlth Sci, Mediclin Panorama, Cape Town, South Africa.
   [De Villiers, T. J.] Univ Stellenbosch, Fac Hlth Sci, Dept Gynaecol, Cape Town, South Africa.
   [Gompel, A.] Univ Paris 05, Hop Univ Paris Ctr, AP HP, UF Gynecol Endocrinienne, Paris, France.
   [Henderson, V. W.] Stanford Univ, Dept Hlth Res & Policy Epidemiol, Stanford, CA 94305 USA.
   [Henderson, V. W.] Stanford Univ, Dept Neurol & Neurol Sci, Stanford, CA 94305 USA.
   [Hodis, H. N.] Univ So Calif, Atherosclerosis Res Unit, Los Angeles, CA USA.
   [Lumsden, M. A.] Univ Glasgow, Glasgow G12 8QQ, Lanark, Scotland.
   [Mack, W. J.] Univ So Calif, Dept Prevent Med, Los Angeles, CA 90089 USA.
   [Shapiro, S.] Univ Cape Town, Sch Med, Dept Publ Hlth & Family Med, ZA-7925 Cape Town, South Africa.
   [Baber, R. J.] Univ Sydney, Sydney Med Sch, Sydney, NSW 2006, Australia.
C3 Columbia University; Monash University; Stellenbosch University;
   Stellenbosch University; Universite Paris Cite; Assistance Publique
   Hopitaux Paris (APHP); Hopital Universitaire Cochin - APHP; Stanford
   University; Stanford University; University of Southern California;
   University of Glasgow; University of Southern California; University of
   Cape Town; University of Sydney
RP Lobo, RA (corresponding author), Columbia Univ, Dept Obstet & Gynecol, New York, NY 10027 USA.
EM ral35@columbia.edu
RI Henderson, V/AAW-4744-2021; Davis, Susan/A-3111-2009; Gompel,
   Anne/AAV-3132-2020
OI Davis, Susan R/0000-0002-2955-0415; Baber, Rodney/0000-0002-7043-5099;
   Henderson, Victor/0000-0003-1198-9240
FU NHMRC Australia [1041853]; Trimel Pharmaceuticals Canada; Lawley
   Pharmaceuticals Australia; Besins Healthcare; National Institutes of
   Health
FX Professor S. R. Davis has received a Research Fellowship Grant no.
   1041853 from NHMRC Australia, consultancy fees from Trimel
   Pharmaceuticals Canada, and unrestricted grant support from Lawley
   Pharmaceuticals Australia and Besins Healthcare; Dr T.J. de Villiers has
   received honoraria for lectures for Bayer, Abbott and Pfizer and for
   acting as a member of Advisory Boards for Merck and Amgen, and travel
   assistance from Pfizer; Professor A. Gompel has received honoraria for
   lectures for Viropharma and funding to a non-profit organization for
   consultancy work for Behring, Richter, and Shire; Dr W. J. Mack and
   Professor H. N. Hodis have received Research grants from the National
   Institutes of Health; Professor S. Shapiro has received honoraria for
   acting as a member of Advisory Boards for Bayer Schering and Merck;
   Professor R. J. Baber has received honoraria for lectures for Abbott
   Pharmaceuticals. Professors R. A. Lobo, V. W. Henderson and M. A.
   Lumsden report no conflicts of interest.
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NR 163
TC 182
Z9 202
U1 2
U2 55
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1369-7137
EI 1473-0804
J9 CLIMACTERIC
JI Climacteric
PD OCT
PY 2014
VL 17
IS 5
BP 540
EP 556
DI 10.3109/13697137.2014.933411
PG 17
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA AP7SQ
UT WOS:000342277400005
PM 24969415
OA Green Published
DA 2025-06-11
ER

PT J
AU Stratakis, CA
AF Stratakis, C. A.
TI Adrenocortical tumors, primary pigmented adrenocortical disease
   (PPNAD)/Carney complex, and other bilateral hyperplasias: the NIH
   studies
SO HORMONE AND METABOLIC RESEARCH
LA English
DT Article; Proceedings Paper
CT Symposium on Cortisol Secretion Abnormalities
CY JUN, 2006
CL Bethesda, MD
SP NICHD
DE adrenal cortex genetics; tumor; primary pigmented adreno cortical
   disease (PPNAD); carney complex; hyperplasias
ID BECKWITH-WIEDEMANN SYNDROME; ADRENAL-CORTICAL CARCINOMA; SPOTTY SKIN
   PIGMENTATION; INCLUDING CARDIAC MYXOMA; LINE P53 MUTATIONS; CARNEY
   COMPLEX; ENDOCRINE OVERACTIVITY; CUSHINGS-SYNDROME; SPECIAL
   ASSOCIATIONS; ONCOGENIC MUTATIONS
AB It has been estimated that up to 1 in 10 adults has at least one adrenocortical nodule up to 1 cm on autopsy; these benign tumors may contribute to metabolic syndrome, hypertension, obesity and abnormalities of the hypothalamic-pituitary adrenal (HPA) axis that can be linked to other serious disorders such as osteoporosis, depression and late-onset diabetes mellitus. In addition, up to 1 in 1500 of these adrenal "incidentalomas" may hide a carcinoma, which, if diagnosed late or left untreated, is associated with significant morbidity and mortality. Consistent with the theme of this symposium, in the present report, we review the efforts undertaken at the National Institutes of Health (NIH) in the last quarter century to unravel the complex clinical genetics and molecular mechanisms involved in adrenal tumorigenesis. We first proposed that adrenocortical tumors form in a molecular sequence of events similar to that in other organs: as the pathology of the tumor increases towards malignancy, genetic changes accumulate. For example, known genetic associations, like TP53 gene changes, occur during the latest stages of adrenocortical tumorigenesis. At the NIH, significant progress has been made in the understanding of the genetics of primary pigmented adrenocortical disease (PPNAD) and other forms of bilateral adrenocortical hyperplasias. This recently led to the identification of phosphodiesterase 11 A (PDE11A) mutations as a low-penetrance predisposing factor to adrenocortical hyperplasias of both the pigmented and non-pigmented variants.
C1 Natl Inst Child Hlth & Human Dev, Program Genet & Endocrinol, NIH, Bethesda, MD 20892 USA.
C3 National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver
   National Institute of Child Health & Human Development (NICHD)
RP Stratakis, CA (corresponding author), Natl Inst Child Hlth & Human Dev, Program Genet & Endocrinol, NIH, Bldg 10 CRC Room 1 East 3330,10 Ctr Dr,MSC 1103, Bethesda, MD 20892 USA.
EM stratakc@mail.nih.gov
RI Stratakis, Constantine/AAP-4745-2020
OI Stratakis, Constantine/0000-0002-4058-5520
FU Intramural NIH HHS Funding Source: Medline
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NR 96
TC 48
Z9 51
U1 0
U2 3
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0018-5043
EI 1439-4286
J9 HORM METAB RES
JI Horm. Metab. Res.
PD JUN
PY 2007
VL 39
IS 6
BP 467
EP 473
DI 10.1055/s-2007-981477
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Endocrinology & Metabolism
GA 185SP
UT WOS:000247731000012
PM 17578766
DA 2025-06-11
ER

PT J
AU Kimura, T
   Matsumoto, T
   Akiyoshi, M
   Owa, Y
   Miyasaka, N
   Aso, T
   Moritani, T
AF Kimura, Tetsuya
   Matsumoto, Tamaki
   Akiyoshi, Mihoko
   Owa, Yoko
   Miyasaka, Naoyuki
   Aso, Takeshi
   Moritani, Toshio
TI Body fat and blood lipids in postmenopausal women are related to resting
   autonomic nervous system activity
SO EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
LA English
DT Article
DE menopause; autonomic nervous system; heart rate variability; body
   composition; dyslipidemia
ID HEART-RATE-VARIABILITY; METABOLIC SYNDROME; OBESE; YOUNG; MENOPAUSE;
   PERIMENOPAUSAL; PRESSURE; BALANCE; DISEASE; RISK
AB The present study investigated the activity of the autonomic nervous system (ANS), a major influence in normal physiological function, and its association with unfavorable postmenopausal states in body composition, lipid and/or glucose metabolism, or cardiovascular profiles. Body composition, blood pressure, and blood profiles of lipid and glucose of 175 postmenopausal women were measured. Resting ANS activity was assessed by heart rate variability (HRV) power spectral analysis. To scrutinize the influence of ANS activity levels on postmenopausal obesity-related factors, we divided the subjects into a low group (< 220 ms(2)) and a high group (> 220 ms(2)), based on the total power of HRV. Low-frequency (P < 0.01) and high-frequency power (P < 0.01) were both significantly lower in the low group. No significant difference was found in age, age at menopause, or years after menopause between the two groups. In contrast, body mass index (P < 0.05), percentages of body fat (P < 0.01), and systolic (P < 0.01) and diastolic (P < 0.01) blood pressure were significantly greater in the low group. As to blood lipid profiles, triglycerides (P < 0.05), total cholesterol (P < 0.05), and low-density lipoprotein cholesterol (P < 0.05) were significantly higher in the low group. Our findings indicate that reduced sympatho-vagal activity is associated with higher postmenopausal body fat content, blood pressure, and blood lipid concentrations. This study further implies that such autonomic depression could be a crucial risk factor in undermining the health and, ultimately, the quality of life, of postmenopausal women.
C1 Kyoto Univ, Grad Sch Human & Environm Studies, Appl Physiol Lab, Sakyo Ku, Kyoto 6068501, Japan.
   Int Buddhist Univ, Dept Hlth Sci, Osaka, Japan.
   Tokyo Med & Dent Univ, Grad Sch, Tokyo, Japan.
C3 Kyoto University; Institute of Science Tokyo; Tokyo Medical & Dental
   University (TMDU)
RP Moritani, T (corresponding author), Kyoto Univ, Grad Sch Human & Environm Studies, Appl Physiol Lab, Sakyo Ku, Kyoto 6068501, Japan.
EM t.moritani@neuro.mbox.media.kyoto-u.ac.jp
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NR 40
TC 51
Z9 58
U1 0
U2 6
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1439-6319
EI 1439-6327
J9 EUR J APPL PHYSIOL
JI Eur. J. Appl. Physiol.
PD JUL
PY 2006
VL 97
IS 5
BP 542
EP 547
DI 10.1007/s00421-006-0207-8
PG 6
WC Physiology; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology; Sport Sciences
GA 061CB
UT WOS:000238847700006
PM 16779552
DA 2025-06-11
ER

PT J
AU Wang, DD
   Chen, LL
   Shi, WX
   Zhang, TT
AF Wang, Dandan
   Chen, Lilin
   Shi, Wenxing
   Zhang, Tiantian
TI Association of circadian syndrome with risk of hyperuricemia among
   middle-aged and older adults in China: The first nationwide cohort study
SO PUBLIC HEALTH
LA English
DT Article
DE Circadian syndrome; Cohort; Hyperuricemia; Metabolic disorders;
   Middle-aged and older adult
ID FRUCTOSE; DISEASE
AB Objectives: No studies have been conducted to explore the association of circadian syndrome (CircS) and hyperuricemia. We addressed the gap by investigating the association of CircS and the risk of hyperuricemia among middle-aged and older adults in China. Study design: Prospective cohort study. Methods: We utilized a nationwide cohort from the China Health and Retirement Longitudinal Study, 7009 adults aged at least 45 years were enrolled at baseline in 2011, and 4415 participants followed up to 2015. CircS was assessed using seven components including five components used to define metabolic syndrome and two components of lack of sleep and depression. Multivariable logistic regression analysis was applied to examine the association of CircS and hyperuricemia. Stratified analyses were used to identify the vulnerable subgroup. Results: Among the 7009 participants (mean age: 60.6 [SD: 9.8] years), 52.8 % were women. Compared to participants without CircS, those with CircS had a higher risk of hyperuricemia (adjusted odds ratio, aOR 2.246, 95 % CI:1.819-2.773). After 4-year follow-up, 457 (10.4 %) cases developed as hyperuricemia. The longitudinal analyses showed that CircS had a higher risk of incident hyperuricemia (aOR 2.136, 1.740-2.620). The association was stronger in women and those with kidney disease. Sensitivity analysis showed that individuals with >= six CircS components had the highest risk of hyperuricemia. Conclusions: This nationwide cohort first revealed that CircS was related to an increased risk of hyperuricemia among Chinese adults. Our findings provide epidemiological evidence regarding the importance of CircS management as a preventative strategy for hyperuricemia.
C1 [Wang, Dandan; Zhang, Tiantian] Fudan Univ, Sch Publ Hlth, Shanghai 200032, Peoples R China.
   [Chen, Lilin] Hong Kong Polytech Univ, Sch Optometry, Hong Kong 999077, Peoples R China.
   [Shi, Wenxing] Anhui Med Univ, Clin Coll, Dept Pharm & Biomed Engn, Hefei 230031, Peoples R China.
C3 Fudan University; Hong Kong Polytechnic University; Anhui Medical
   University
RP Zhang, TT (corresponding author), Fudan Univ, Sch Publ Hlth, Shanghai 200032, Peoples R China.
EM tiantianzhang18@fudan.edu.cn
RI Wenxing, Shi/KVC-0243-2024; Wang, Dandan/ABB-4875-2020
FU National Nature Science Foundation of China [72204048]
FX This study was of China (No. 72204048) . Competing interests There are
   no conflicting Acknowledgements We would like Longitudinal Study of
   using the dataset. Data and resource availability The data can be cn/en.
   A.
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NR 32
TC 0
Z9 0
U1 4
U2 4
PU W B SAUNDERS CO LTD
PI LONDON
PA 32 JAMESTOWN RD, LONDON NW1 7BY, ENGLAND
SN 0033-3506
EI 1476-5616
J9 PUBLIC HEALTH
JI Public Health
PD JAN
PY 2025
VL 238
BP 23
EP 28
DI 10.1016/j.puhe.2024.10.002
EA NOV 2024
PG 6
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA N6B6O
UT WOS:001365173600001
PM 39579614
DA 2025-06-11
ER

PT J
AU Point, C
   Wacquier, B
   Dosogne, M
   Al Faker, M
   Willame, H
   Loas, G
   Hein, M
AF Point, Camille
   Wacquier, Benjamin
   Dosogne, Marjorie
   Al Faker, Mohammed
   Willame, Hadrien
   Loas, Gwenole
   Hein, Matthieu
TI Impact of Alexithymia on the Lipid Profile in Major Depressed
   Individuals
SO JOURNAL OF LIPIDS
LA English
DT Article
ID DISEASE RISK-FACTORS; ADIPONECTIN LEVELS; METABOLIC SYNDROME;
   PREVALENCE; ADULTS; ASSOCIATION; OUTPATIENTS; HEALTH
AB Background. The cooccurrence of major depression and dyslipidaemia is associated with negative cardiovascular outcome, which seems to justify a better identification of the factors favouring the development of dyslipidaemia in major depressed individuals. In the literature, there are arguments in favour of a special relationship between dyslipidaemia and alexithymia. However, despite a high prevalence of alexithymia in major depressed individuals, no study has investigated the impact of this personality trait on the lipid profile in this particular subpopulation. Given these elements, the aim of this study was therefore to investigate the risk of dyslipidaemia associated with alexithymia in major depressed individuals to allow better cardiovascular prevention in this subpopulation. Subjects and Methods. Demographic and polysomnographic data from 242 major depressed individuals recruited from the clinical database of the sleep laboratory were analysed. Only individuals with a diagnosis of dyslipidaemia according to the diagnostic criteria of the International Diabetes Federation at admission were included in the "dyslipidaemia" group. Logistic regression analyses were used to determine the risk of dyslipidaemia associated with alexithymia in major depressed individuals. Results. The prevalence of dyslipidaemia was 43.8% in our sample of major depressed individuals. After adjusting for the main confounding factors, multivariate logistic regression analyses demonstrated that alexithymia was a risk factor for dyslipidaemia in major depressed individuals. Conclusions. In this study, we found that alexithymia is a risk factor for dyslipidaemia in major depressed individuals, which seems to justify better identification and adequate management of this personality trait in order to allow a better lipid profile in this subpopulation at high cardiovascular risk.
C1 [Point, Camille; Wacquier, Benjamin; Dosogne, Marjorie; Al Faker, Mohammed; Willame, Hadrien; Loas, Gwenole; Hein, Matthieu] Univ Libre Bruxelles ULB, Erasme Hosp, Dept Psychiat, Sleep Lab, Brussels, Belgium.
C3 Universite Libre de Bruxelles
RP Hein, M (corresponding author), Univ Libre Bruxelles ULB, Erasme Hosp, Dept Psychiat, Sleep Lab, Brussels, Belgium.
EM camille.point@erasme.ulb.ac.be; benjamin.wacquier@erasme.ulb.ac.be;
   marjorie.dosogne@ulb.be; mohammed.al.faker@ulb.be;
   hadrien.willame@erasme.ulb.ac.be; gwenole.loas@erasme.ulb.ac.be;
   matthieu.hein@ulb.be
RI Hein, Matthieu/IVV-2577-2023
OI Wacquier, Benjamin/0000-0002-5603-4600; Hein,
   Matthieu/0000-0003-4243-1653
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NR 50
TC 1
Z9 1
U1 0
U2 1
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2090-3030
EI 2090-3049
J9 J LIPIDS
JI J. Lipids
PD JUN 16
PY 2022
VL 2022
AR 5450814
DI 10.1155/2022/5450814
PG 11
WC Biochemistry & Molecular Biology
WE Emerging Sources Citation Index (ESCI)
SC Biochemistry & Molecular Biology
GA 2L7GH
UT WOS:000817185900001
PM 35755481
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Lee, J
   Go, TH
   Min, S
   Koh, SB
   Choi, JR
AF Lee, Jinhee
   Go, Tae Hwa
   Min, Seongho
   Koh, Sang Baek
   Choi, Jung Ran
TI Association between lifestyle factors and metabolic syndrome in general
   populations with depressive symptoms in cross-setional based cohort
   study of Ansung-Ansan
SO PLOS ONE
LA English
DT Article
ID PRIMARY PREVENTION; DISEASE; METAANALYSIS
AB BackgroundMetabolic syndrome (MetS) is caused by both genetic and environmental factors, such as daily calorie intake, smoking, and alcohol consumption. Lifestyle factors, such as alcohol consumption, are considered to be related to the prevalence of MetS and plays an essential role in the pathogenesis and prognosis of depression. MethodsWe investigated the bidirectional association between lifestyle factors and MetS among Korean adults with depressive symptoms in third wave of a community-based cohort study. A total of 1,578 individuals, aged 39-72 years, who had MetS at baseline were recruited. Participants were divided into two groups according to depressive symptoms. Logistic regression models were used to estimate the risk of MetS. ResultsThe percentage of heavy drinkers was lower in men with depressive symptoms compared to those who did not (7.0% vs. 7.1%), while the percentage of current smokers were higher in participants who had depressive symptoms (40.2% vs. 30.0%). After adjusting for age, education, monthly income, body mass index (BMI), sleep duration, and volume of drinking and smoking status, logistic regression analysis demonstrated that male heavy drinkers with depressive symptoms were 2.75 times more likely to have MetS than those without depressive symptom. Conversely, depressive women with a high BMI were 3.70 times more likely to have MetS than in those with lower BMI. Limitations The cross-sectional nature of the study, and the study population ethnicity and ages were limitations. ConclusionsLifestyle factors, such as alcohol consumption, may be associated with the risk of MetS in adults with depressive symptoms.
C1 [Lee, Jinhee; Min, Seongho] Yonsei Univ, Wonju Coll Med, Dept Psychiat, Wonju, South Korea.
   [Go, Tae Hwa] Yonsei Univ, Wonju Coll Med, Ctr Biomed Data Sci, Wonju, South Korea.
   [Koh, Sang Baek; Choi, Jung Ran] Yonsei Univ, Wonju Coll Med, Inst Genom Cohort, Wonju, South Korea.
   [Koh, Sang Baek] Yonsei Univ, Wonju Coll Med, Dept Prevent Med, Wonju, South Korea.
C3 Yonsei University; Yonsei University; Yonsei University; Yonsei
   University
RP Choi, JR (corresponding author), Yonsei Univ, Wonju Coll Med, Inst Genom Cohort, Wonju, South Korea.
EM christinae@yonsei.ac.kr
RI Lee, Jee-Yon/GER-4141-2022
FU Korea Centers for Disease Control and Prevention [2005-E71013-00,
   2006-E71002-00, 2007-E71013-00, 2008-E71004-00, 2009-E71006-00,
   2010-E71003-00]; Basic Science Research Program through the National
   Research Foundation of Korea (NRF) - Ministry of Education
   [2017R1D1A3B03034119, 2020R1I1A3A04036555, NRF-2020R1I1A1A01070465];
   Medical Research Center Program [2017R1A5A2015369]; Yonsei University
FX This study was supported by the Korea Centers for Disease Control and
   Prevention (2005-E71013-00, 2006-E71002-00, 2007-E71013-00,
   2008-E71004-00, 2009-E71006-00, and 2010-E71003-00); the Basic Science
   Research Program through the National Research Foundation of Korea (NRF)
   funded by the Ministry of Education (2017R1D1A3B03034119,
   2020R1I1A3A04036555, NRF-2020R1I1A1A01070465); the Medical Research
   Center Program (2017R1A5A2015369); and the Yonsei University Research
   Fund 2017.
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NR 24
TC 4
Z9 4
U1 0
U2 8
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PY 2022
VL 17
IS 3
AR e0262526
DI 10.1371/journal.pone.0262526
PG 10
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 1M3VR
UT WOS:000799901400024
PM 35290376
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Castelnuovo, G
   Perez-Diaz-del-Campo, N
   Rosso, C
   Guariglia, M
   Armandi, A
   Nicolosi, A
   Caviglia, GP
   Bugianesi, E
AF Castelnuovo, Gabriele
   Perez-Diaz-del-Campo, Nuria
   Rosso, Chiara
   Guariglia, Marta
   Armandi, Angelo
   Nicolosi, Aurora
   Caviglia, Gian Paolo
   Bugianesi, Elisabetta
TI Impact of Chronotype and Mediterranean Diet on the Risk of Liver
   Fibrosis in Patients with Non-Alcoholic Fatty Liver Disease
SO NUTRIENTS
LA English
DT Article
DE chronotype; non-alcoholic fatty liver disease; liver fibrosis;
   Mediterranean diet
ID LIFE-STYLE; EVENING CHRONOTYPE; SLEEP; NAFLD; ASSOCIATION; MANAGEMENT;
   DISORDERS; DIAGNOSIS; CLOCKS; NASH
AB Late chronotype, the individual's aptitude to perform daily activities late in the day, has been associated with low adherence to the Mediterranean diet (MedDiet) and metabolic syndrome. The aim of this work was to investigate the potential association of chronotype and adherence to the MedDiet with the liver fibrosis risk in patients with non-alcoholic fatty liver disease (NAFLD). Liver stiffness was assessed in 126 patients by FibroScan(& REG;)530. Significant (F & GE; 2) and advanced (F & GE; 3) hepatic fibrosis were defined according to liver stiffness values & GE;7.1 kPa and & GE;8.8 kPa, respectively. Chronotype (MSFsc) was defined by the Munich Chronotype Questionnaire, and adherence to the MedDiet was defined by the Mediterranean diet score (MDS). Overall, the median age was 55 (46-63) years, and 57.9% of participants were male. The principal comorbidities were type-2 diabetes mellitus (T2DM) (26.1%), arterial hypertension (53.1%), dyslipidaemia (63.4%), obstructive sleep apnoea (5.5%) and depression (5.5%). Most subjects (65.0%) had intermediate + late chronotype and showed higher mid-sleep on workdays (p < 0.001) and on work-free days (p < 0.001) compared to those with early chronotype. In the logistic regression model, intermediate + late chronotype (p = 0.024), MDS (p = 0.019) and T2DM (p = 0.004) were found to be significantly and independently associated with the risk of both F & GE; 2 And F & GE; 3. We observed that the intermediate + late chronotype and low adherence to the MedDiet were associated with both significant and advanced liver fibrosis in patients with NAFLD.
C1 [Castelnuovo, Gabriele; Perez-Diaz-del-Campo, Nuria; Rosso, Chiara; Guariglia, Marta; Armandi, Angelo; Nicolosi, Aurora; Caviglia, Gian Paolo; Bugianesi, Elisabetta] Univ Turin, Dept Med Sci, I-10126 Turin, Italy.
   [Armandi, Angelo] Univ Med Ctr Johannes Gutenberg, Dept Med 1, Metab Liver Dis Res Program, D-55131 Mainz, Germany.
   [Bugianesi, Elisabetta] Citta Salute & Sci Molinette Hosp, Gastroenterol Unit, I-10126 Turin, Italy.
C3 University of Turin; Johannes Gutenberg University of Mainz; A.O.U.
   Citta della Salute e della Scienza di Torino; AOU San Giovanni
   Battista-Molinette
RP Perez-Diaz-del-Campo, N; Bugianesi, E (corresponding author), Univ Turin, Dept Med Sci, I-10126 Turin, Italy.; Bugianesi, E (corresponding author), Citta Salute & Sci Molinette Hosp, Gastroenterol Unit, I-10126 Turin, Italy.
EM gabriele.castelnuovo@unito.it; nuria.perezdiazdelcampo@unito.it;
   chiara.rosso@unito.it; marta.guariglia@unito.it;
   angelo.armandi@unito.it; aurora.nicolosi@unito.it;
   gianpaolo.caviglia@unito.it; elisabetta.bugianesi@unito.it
RI Rosso, Chiara/AAY-4336-2021; Castelnuovo, Gabriele/HHS-5728-2022;
   Armandi, Angelo/AAU-6395-2020; Caviglia, Gian/H-6076-2012; Bugianesi,
   Elisabetta/K-8008-2016; Perez-Diaz-del-Campo, Nuria/HGC-4070-2022
OI Armandi, Angelo/0000-0002-7245-4445; Castelnuovo,
   Gabriele/0000-0002-9985-1440; Rosso, Chiara/0000-0001-6518-7089;
   Caviglia, Gian Paolo/0000-0002-0529-9481; Bugianesi,
   Elisabetta/0000-0002-0502-4381; Perez Diaz del Campo,
   Nuria/0000-0003-0479-8825
FU University of Turin [ROSC_RILO_21_01]; Italian Ministry for Education,
   University and Research (Ministero dell'Istruzione, dell'Universita e
   della RicercaMIUR)- [D15D18000410001]
FX The research was funded by the University of Turin, grant number
   ROSC_RILO_21_01 and by the Italian Ministry for Education, University
   and Research (Ministero dell'Istruzione, dell'Universita e della
   Ricerca-MIUR) under the programme "Dipartimenti di Eccellenza 2018-2022"
   Project code D15D18000410001.
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NR 56
TC 2
Z9 2
U1 2
U2 10
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JUL
PY 2023
VL 15
IS 14
AR 3257
DI 10.3390/nu15143257
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA N7TN8
UT WOS:001038993800001
PM 37513675
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Ford, K
   Sowers, M
   Seeman, TE
   Greendale, GA
   Sternfeld, B
   Everson-Rose, SA
AF Ford, Kathleen
   Sowers, MaryFran
   Seeman, Teresa E.
   Greendale, Gail A.
   Sternfeld, Barbara
   Everson-Rose, Susan A.
TI Cognitive Functioning Is Related to Physical Functioning in a
   Longitudinal Study of Women at Midlife
SO GERONTOLOGY
LA English
DT Article
DE Physical functioning; Cognitive functioning; Menopause; Metabolic
   syndrome; MOS SF-36
ID ESTROGEN REPLACEMENT THERAPY; DEPRESSIVE SYMPTOMS; EXECUTIVE CONTROL;
   RISK-FACTORS; HEALTH; ASSOCIATION; PERFORMANCE; COMMUNITY; DECLINE;
   BRAIN
AB Background: Studies have reported declines with age in cognitive or physical functioning, but rarely identify whether these are parallel or linked events in the same study. Furthermore, most research in this area has focused on persons in late life rather than midlife. Objective: The objective of the study was to determine (1) if cognitive functioning was related to physical functioning and whether this relationship persisted after adjustment for age, menopause status, metabolic status, depression and socioeconomic resources, and (2) if changes in physical functioning were associated with changes in cognitive functioning over a 4-year follow-up period. Methods: Data were from the Study of Women's Health Across the Nation (SWAN), a multi-site, longitudinal study of women aged 46-56 years at follow-up examination 4. Three follow-up examinations (study years 04, 06 and 08) included measures of physical functioning perception (MOS SF-36) and cognitive functioning [ Symbol Digit Modality Test (SDMT), Digit Span Backward Test (DSBT), and East Boston Memory Test (EBMT)] (n = 2,405). Results: Women with lower cognitive functioning scores also had lower perceived physical functioning scores. While adjustment for covariates attenuated the association between perceived physical functioning and both the SDMT and EBMT cognitive measures, these associations remained statistically significant. Additionally, the 4-year change in perceived physical functioning was significantly associated with the 4-year change in the EBMT. Conclusions: At midlife, there were associated declines in cognitive and perceived physical functioning scores, commencing at midlife in women. Copyright (C) 2009 S. Karger AG, Basel
C1 [Ford, Kathleen; Sowers, MaryFran] Univ Michigan, Dept Epidemiol, Ann Arbor, MI 48104 USA.
   [Seeman, Teresa E.; Greendale, Gail A.] Univ Calif Los Angeles, Sch Med, Div Geriatr, Los Angeles, CA USA.
   [Sternfeld, Barbara] Kaiser, Div Res, Oakland, CA USA.
   [Everson-Rose, Susan A.] Univ Minnesota, Dept Med, Minneapolis, MN 55455 USA.
C3 University of Michigan System; University of Michigan; University of
   California System; University of California Los Angeles; University of
   California Los Angeles Medical Center; David Geffen School of Medicine
   at UCLA; University of Minnesota System; University of Minnesota Twin
   Cities
RP Ford, K (corresponding author), Univ Michigan, Dept Epidemiol, Ann Arbor, MI 48104 USA.
EM kford@umich.edu
RI Everson-Rose, Susan/L-7582-2017; Ford, Kathleen/KCK-3499-2024
OI Everson-Rose, Susan/0000-0002-9839-2537
FU National Institutes of Health, DHHS, through the National Institute on
   Aging, the National Institute of Nursing Research [NR004061, AG012505,
   AG012535, AG012531, AG012539, AG012546, AG012553, AG012554, AG012495];
   National Institute on Aging [P30AG012846] Funding Source: NIH RePORTER
FX The Study of Women's Health Across the Nation (SWAN) has grant support
   from the National Institutes of Health, DHHS, through the National
   Institute on Aging, the National Institute of Nursing Research and the
   NIH Office of Research on Women's Health (grants NR004061, AG012505,
   AG012535, AG012531, AG012539, AG012546, AG012553, AG012554, AG012495).
   The content of this article is solely the responsibility of the authors
   and does not necessarily represent the official views of the NIA, NINR,
   ORWH or the NIH.
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NR 40
TC 9
Z9 14
U1 0
U2 11
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0304-324X
EI 1423-0003
J9 GERONTOLOGY
JI Gerontology
PY 2010
VL 56
IS 3
BP 250
EP 258
DI 10.1159/000247132
PG 9
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA 588FQ
UT WOS:000277053800002
PM 19828933
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU McCarty, MF
AF McCarty, Mark F.
TI High-dose folate may improve platelet function in acute coronary
   syndrome and other pathologies associated with increased platelet
   oxidative stress
SO MEDICAL HYPOTHESES
LA English
DT Review
ID NITRIC-OXIDE SYNTHASE; VASCULAR ENDOTHELIAL DYSFUNCTION; VITAMIN-C
   THERAPY; ASCORBIC-ACID; FOLIC-ACID; ARTERY-DISEASE; DIABETES-MELLITUS;
   SUPEROXIDE ANION; GUANOSINE-3',5'-CYCLIC MONOPHOSPHATE; FAMILIAL
   HYPERCHOLESTEROLEMIA
AB Although nitric oxide of endothelial origin plays a major role in warding off inappropriate thrombus formation, platelets also express the "constitutive" isoform of nitric oxide synthase (cNOS). Activation of this enzyme by calcium influx during platelet aggregation provides an important feedback signal that dampens platelet recruitment. Platelets also express a membrane-bound NAD(P)H oxidase complex, activated by collagen receptors, that produces superoxide. Superoxide can directly quench NO; moreover, by giving rise to peroxynitrite, it can oxidize the cNOS cofactor tetrahydrobiopterin (BH4), thereby suppressing cNOS activity and converting it to superoxide generator. In a canine model of acute coronary syndrome, infusion of BH4 has been shown to prevent thrombus formation. Platelets from patients with acute coronary syndrome produce markedly Less NO than do control platelets. A reasonable explanation for these findings is that episodic contact with collagen boosts platelet superoxide production, oxidizing BH4. Since 5-methyltetrahydrofolate can reduce oxidized BH4, or otherwise compensate for its deficiency, supplementation with its precursor folic acid may improve platelet function in acute coronary syndrome and possibly reduce risk for coronary thrombosis in other at-risk patients. Other research demonstrates that superoxide production is increased, and nitric oxide production diminished, in platelets of diabetics; the ability of glutathione - a peroxynitrite scavenger - to largely ameliorate these abnormalities, is consistent with a prominent role for BH4 deficiency in diabetic platelet malfunction. Reports that platelet NO production is decreased, and/or superoxide production increased, in patients with disorders associated with insulin resistance syndrome, suggest that BH4 deficiency - potentially remediable with high-dose folate - may likewise contribute to the platelet hyperreactivity noted in these disorders. Supplemental vitamin C and arginine also have the potential to boost platelet production of NO Increased intakes of taurine, magnesium, gamma-tocopherol, fish oil, and garlic may help to stabilize platelets by additional mechanisms. As a complement to the proven benefits of low-dose aspirin, a supplemental regimen emphasizing these nutrients in appropriate doses may act directly on platelets to further diminish risk for thrombotic episodes. (c) 2006 Elsevier Ltd. All rights reserved.
C1 Nat Alternat Int, San Marcos, CA 92078 USA.
RP McCarty, MF (corresponding author), Nat Alternat Int, 1185 Linda Vista Rd, San Marcos, CA 92078 USA.
EM mccarty@pantox.com
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NR 112
TC 10
Z9 11
U1 0
U2 12
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0306-9877
EI 1532-2777
J9 MED HYPOTHESES
JI Med. Hypotheses
PY 2007
VL 69
IS 1
BP 12
EP 19
DI 10.1016/j.mehy.2004.08.035
PG 8
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 178PP
UT WOS:000247232900004
PM 17293058
DA 2025-06-11
ER

PT J
AU Valenzuela, M
   Amato, R
   Sgura, A
   Antoccia, A
   Berardinelli, F
AF Valenzuela, Martina
   Amato, Roberta
   Sgura, Antonella
   Antoccia, Antonio
   Berardinelli, Francesco
TI The Multiple Facets of ATRX Protein
SO CANCERS
LA English
DT Review
DE ATRX; Epigenetics; chromatin remodeling; telomere; replicative stress
   response; genome stability
ID INACTIVE X-CHROMOSOME; HERPES-SIMPLEX-VIRUS; HISTONE VARIANT H3.3;
   TRANSCRIPTIONAL REGULATOR ATRX; SISTER TELOMERE ASSOCIATION;
   PROMYELOCYTIC LEUKEMIA; ADD DOMAIN; PERICENTRIC HETEROCHROMATIN;
   MENTAL-RETARDATION; FREQUENT ATRX
AB Simple Summary
   The gene encoding for the epigenetic regulator ATRX is gaining a prominent position among the most important oncosuppressive genes of the human genome. ATRX gene somatic mutations are found across a number of diverse cancer types, suggesting its relevance in tumor induction and progression. In the present review, the multiple activities of ATRX protein are described in the light of the most recent literature available highlighting its multifaceted role in the caretaking of the human genome.
   ATRX gene codifies for a protein member of the SWI-SNF family and was cloned for the first time over 25 years ago as the gene responsible for a rare developmental disorder characterized by alpha-thalassemia and intellectual disability called Alpha Thalassemia/mental Retardation syndrome X-linked (ATRX) syndrome. Since its discovery as a helicase involved in alpha-globin gene transcriptional regulation, our understanding of the multiple roles played by the ATRX protein increased continuously, leading to the recognition of this multifaceted protein as a central "caretaker" of the human genome involved in cancer suppression. In this review, we report recent advances in the comprehension of the ATRX manifold functions that encompass heterochromatin epigenetic regulation and maintenance, telomere function, replicative stress response, genome stability, and the suppression of endogenous transposable elements and exogenous viral genomes.
C1 [Valenzuela, Martina; Amato, Roberta; Sgura, Antonella; Antoccia, Antonio; Berardinelli, Francesco] Univ Roma Tre, Dept Sci, I-00146 Rome, Italy.
   [Berardinelli, Francesco] IRCCS Santa Lucia Fdn, Neurogenet & Mol Neurobiol Unit, Lab Neurodev, I-00143 Rome, Italy.
C3 Roma Tre University; Italfarmaco; IRCCS Santa Lucia
RP Berardinelli, F (corresponding author), Univ Roma Tre, Dept Sci, I-00146 Rome, Italy.; Berardinelli, F (corresponding author), IRCCS Santa Lucia Fdn, Neurogenet & Mol Neurobiol Unit, Lab Neurodev, I-00143 Rome, Italy.
EM martina.valenzuela@uniroma3.it; roberta.amato@uniroma3.it;
   antonella.sgura@uniroma3.it; antonio.antoccia@uniroma3.it;
   francesco.berardinelli@uniroma3.it
RI Berardinelli, Francesco/AAP-2355-2021
OI Antoccia, Antonio/0000-0003-1689-3635; Berardinelli,
   Francesco/0000-0002-3094-4139
FU Ateneo Roma Tre; MIUR
FX This study was supported by grants from Ateneo Roma Tre to A.A., and
   A.S. The Grant of Excellence Departments, MIUR (ARTICOLO 1, COMMI
   314-337 LEGGE 232/2016) to Department of Science, University Roma TRE is
   also gratefully acknowledged.
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NR 183
TC 29
Z9 30
U1 0
U2 10
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6694
J9 CANCERS
JI Cancers
PD MAY
PY 2021
VL 13
IS 9
AR 2211
DI 10.3390/cancers13092211
PG 20
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA SB3JF
UT WOS:000649894400001
PM 34062956
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Liu, H
   Dong, HQ
   Jin, MC
   Zhou, Y
   Hao, HD
   Yuan, YT
   Jia, HT
   He, M
AF Liu, Heng
   Dong, Huqiang
   Jin, Mingchu
   Zhou, Yu
   Hao, Haidong
   Yuan, Yutang
   Jia, Hongtao
   He, Min
TI Association between novel anthropometric indices and overactive bladder:
   a population-based study
SO FRONTIERS IN NUTRITION
LA English
DT Article
DE overactive bladder; WWI; BRI; RFM; ABSI; NHANES
ID RELATIVE FAT MASS; METABOLIC SYNDROME; DEPRESSION; WOMEN
AB Background Abdominal obesity is recognized as a key risk factor for developing OAB. However, traditional measures of obesity, such as the waist-to-height ratio (WHtR), waist circumference, and body mass index (BMI), may not sufficiently capture fat distribution in the body. This study aims to evaluate the relationship between novel anthropometric indices and OAB, providing a more accurate assessment of obesity-related risk factors.Methods The National Health and Nutrition Examination Survey (NHANES) data from 2007 to 2018 were utilized, comprising 27,560 participants. To assess the association and discriminative ability of novel anthropometric indices, including the Body Roundness Index (BRI), A Body Shape Index (ABSI), Waist-to-Weight Index (WWI), and Relative Fat Mass (RFM), with OAB, we employed multivariable logistic regression, restricted cubic spline (RCS) analysis, subgroup analysis, and receiver operating characteristic (ROC) curve methods.Results Multivariable logistic regression analysis indicated that higher levels of novel anthropometric indices were positively associated with OAB prevalence. One z-score increase in WWI, BRI, RFM, and ABSI was associated with a 16, 31, 57, and 5% higher likelihood of OAB, respectively. RCS analysis revealed a non-linear relationship between RFM and OAB. ROC analysis indicated that WWI (AUC = 0.680) and RFM (AUC = 0.661) provided better diagnostic accuracy than traditional measures such as BMI (AUC = 0.599). Subgroup analyses supported the robustness of these findings.Conclusion Novel anthropometric indices were positively associated with OAB prevalence. WWI and RFM demonstrated significantly better diagnostic value for OAB than BMI and WHtR. Future studies should investigate the potential of combining multiple anthropometric indices to improve predictive accuracy and conduct prospective studies to determine causality.
C1 [Liu, Heng; Jin, Mingchu; Zhou, Yu; Hao, Haidong; Yuan, Yutang; Jia, Hongtao] Hubei Univ Med, Renmin Hosp, Dept Urol, Shiyan, Peoples R China.
   [Dong, Huqiang] Ningxia Med Univ, Sch Publ Hlth, Yinchuan, Peoples R China.
   [He, Min] Hubei Univ Med, Renmin Hosp, Dept Resp & Crit Care Med, Shiyan, Peoples R China.
C3 Hubei University of Medicine; Ningxia Medical University; Hubei
   University of Medicine
RP Jia, HT (corresponding author), Hubei Univ Med, Renmin Hosp, Dept Urol, Shiyan, Peoples R China.; He, M (corresponding author), Hubei Univ Med, Renmin Hosp, Dept Resp & Crit Care Med, Shiyan, Peoples R China.
EM 539972890@qq.com; hemin1437@163.com
RI Dong, Huqiang/LKN-3224-2024
OI dong, hu qiang/0009-0005-3087-773X
FX The author(s) declare that no financial support was received for the
   research, authorship, and/or publication of this article.
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NR 45
TC 0
Z9 0
U1 3
U2 3
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD JAN 22
PY 2025
VL 12
AR 1493792
DI 10.3389/fnut.2025.1493792
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA U6B0C
UT WOS:001412611100001
PM 39911808
OA gold
DA 2025-06-11
ER

PT J
AU Veronese, N
   Cisternino, AM
   Shivappa, N
   Hebert, JR
   Notarnicola, M
   Reddavide, R
   Inguaggiato, R
   Guerra, V
   Logroscino, A
   Rotolo, O
   Chiloiro, M
   Leandro, G
   De Leonardis, G
   Tutino, V
   Misciagna, G
   Fontana, L
   Caruso, MG
   Giampiero, D
   Anna, M
   Palma, I
   Marisa, N
   Osvaldo, B
   Benedetta, D
   Vittorio, P
AF Veronese, N.
   Cisternino, A. M.
   Shivappa, N.
   Hebert, J. R.
   Notarnicola, M.
   Reddavide, R.
   Inguaggiato, R.
   Guerra, V
   Logroscino, A.
   Rotolo, O.
   Chiloiro, M.
   Leandro, G.
   De Leonardis, G.
   Tutino, V
   Misciagna, G.
   Fontana, L.
   Caruso, M. G.
   Giampiero, De Michele
   Anna, Mastrosimini
   Palma, Iacovazzi
   Marisa, Noviello
   Osvaldo, Burattini
   Benedetta, D'Attoma
   Vittorio, Pugliese
CA MICOL Grp
TI Dietary inflammatory index and mortality: a cohort longitudinal study in
   a Mediterranean area
SO JOURNAL OF HUMAN NUTRITION AND DIETETICS
LA English
DT Article
DE cancer; cardiovascular disease; dietary inflammatory index; mortality
ID C-REACTIVE PROTEIN; METABOLIC SYNDROME; PROSPECTIVE ASSOCIATION;
   ALL-CAUSE; RISK; DISEASE; CANCER; CONSUMPTION; DEPRESSION; SURVIVAL
AB Background Higher Dietary Inflammatory Index (DII (R)) scores are associated with increased morbidity and mortality. However, little is known about the effects of DII on mortality in Mediterranean countries. Therefore, in the present study, we aimed to investigate the potential association between DII scores and overall, cancer and cardiovascular disease (CVD) mortality in people living in a Mediterranean area. Methods DII scores were calculated using a validated food-frequency questionnaire. DII scores were then categorised into tertiles. Mortality was ascertained via death certificates. The association between DII scores with overall and cause-specific mortality was assessed via a multivariable Cox's regression analysis and reported as hazard ratios (HRs) with their 95% confidence intervals (CIs). Results The study included 1565 participants (mean age 65.5 years; females 44.7%). After a median follow-up of 12 years (2005-2017), 366 (23.4%) participants died. After adjusting for 17 potential confounders, people with higher DII scores had an increased risk of death compared to those in the lowest (most anti-inflammatory) tertile (HR = 1.38; 95% CI = 1.04-1.82 for the second tertile; HR = 1.38; 95% CI = 1.03-1.86 for the third tertile). Each 1 SD increase in DII score increased the risk of death by 13%. No association was found between DII scores and cancer or CVD death when considered separately. Conclusions Higher DII scores were associated with a significantly higher mortality risk, whereas the association with cause-specific mortality was less clear. These findings highlight the potential importance of diet in modulating inflammation and preventing death.
C1 [Veronese, N.; Cisternino, A. M.; Reddavide, R.; Inguaggiato, R.; Rotolo, O.; De Leonardis, G.; Caruso, M. G.] S De Bellis Res Hosp, Natl Inst Gastroenterol, Ambulatory Clin Nutr, Bari, Italy.
   [Veronese, N.; Notarnicola, M.; De Leonardis, G.; Tutino, V; Caruso, M. G.] S De Bellis Res Hosp, Natl Inst Gastroenterol, Lab Nutr Biochem, Bari, Italy.
   [Shivappa, N.; Hebert, J. R.] Univ South Carolina, Arnold Sch Publ Hlth, Canc Prevent & Control Program, Columbia, SC 29208 USA.
   [Shivappa, N.; Hebert, J. R.] Univ South Carolina, Arnold Sch Publ Hlth, Dept Epidemiol & Biostat, Columbia, SC 29208 USA.
   [Shivappa, N.; Hebert, J. R.] Connecting Hlth Innovat LLC, Columbia, SC USA.
   [Guerra, V] S De Bellis Res Hosp, Natl Inst Gastroenterol, Clin Trial Unit, Bari, Italy.
   [Logroscino, A.] IRCCS Giovanni Paolo II, Thorac Med Oncol, Bari, Italy.
   [Chiloiro, M.] Hosp San Giacomo, Radiol Unit, Bari, Italy.
   [Leandro, G.] S De Bellis Res Hosp, Natl Inst Gastroenterol, Unit Gastroenterol, Bari, Italy.
   [Misciagna, G.] Univ Hosp Policlin, Sci & Eth Comm, Bari, Italy.
   [Fontana, L.] Univ Sydney, Cent Clin Sch, Sydney, NSW, Australia.
   [Fontana, L.] Univ Sydney, Charles Perkins Ctr, Sydney, NSW, Australia.
   [Fontana, L.] Brescia Univ, Dept Clin & Expt Sci, Med Sch, Brescia, Italy.
   [Giampiero, De Michele; Anna, Mastrosimini; Palma, Iacovazzi] IRCCS Saverio de Bellis, Lab Clin Pathol, Bari, Italy.
   [Marisa, Noviello] IRCCS Saverio de Bellis, Unit Radiol, Bari, Italy.
   [Osvaldo, Burattini] IRCCS Saverio de Bellis, Unit Gastroenterol 2, Bari, Italy.
   [Benedetta, D'Attoma] IRCCS Saverio de Bellis, Lab Nutr Phyisipathol, Bari, Italy.
   [Vittorio, Pugliese] Hosp Monte St Angelo, Putignano, BA, Italy.
C3 University of South Carolina System; University of South Carolina
   Columbia; University of South Carolina System; University of South
   Carolina Columbia; Connecting Health Innovations LLC; Universita degli
   Studi di Bari Aldo Moro; University of Sydney; University of Sydney;
   University of Brescia; IRCCS Saverio de Bellis; IRCCS Saverio de Bellis;
   IRCCS Saverio de Bellis; IRCCS Saverio de Bellis
RP Veronese, N (corresponding author), S De Bellis Res Hosp, Natl Inst Gastroenterol, Via Turi 27, I-70013 Bari, Italy.
EM nicola.veronese@irccsdebellis.it
RI Hebert, James/IUO-5628-2023; Shivappa, Nitin/X-2215-2018; Veronese,
   Nicola/K-4343-2018
OI Veronese, Nicola/0000-0002-9328-289X
CR [Anonymous], J NUTR HLTH AGING
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NR 50
TC 14
Z9 14
U1 2
U2 9
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0952-3871
EI 1365-277X
J9 J HUM NUTR DIET
JI J. Hum. Nutr. Diet.
PD FEB
PY 2020
VL 33
IS 1
BP 138
EP 146
DI 10.1111/jhn.12701
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA KB0CY
UT WOS:000506168000015
PM 31829488
DA 2025-06-11
ER

PT J
AU Lemos, C
   Rial, D
   Gonçalves, FQ
   Pires, J
   Silva, HB
   Matheus, FC
   Da Silva, AC
   Marques, JM
   Rodrigues, RJ
   Jarak, I
   Prediger, RD
   Reis, F
   Carvalho, RA
   Pereira, FC
   Cunha, RA
AF Lemos, C.
   Rial, D.
   Goncalves, F. Q.
   Pires, J.
   Silva, H. B.
   Matheus, F. C.
   Da Silva, A. C.
   Marques, J. M.
   Rodrigues, R. J.
   Jarak, I.
   Prediger, R. D.
   Reis, F.
   Carvalho, R. A.
   Pereira, F. C.
   Cunha, R. A.
TI HIGH SUCROSE CONSUMPTION INDUCES MEMORY IMPAIRMENT IN RATS ASSOCIATED
   WITH ELECTROPHYSIOLOGICAL MODIFICATIONS BUT NOT WITH METABOLIC CHANGES
   IN THE HIPPOCAMPUS
SO NEUROSCIENCE
LA English
DT Article
DE sucrose; memory; Adenosine; hippocampus; synaptic plasticity
ID ADENOSINE A(2A) RECEPTORS; LONG-TERM POTENTIATION;
   SYNAPTIC-TRANSMISSION; MEDIATED INHIBITION; GLUCOSE-METABOLISM;
   INSULIN-RESISTANCE; NERVE-TERMINALS; DIFFERENT ROLES; A(1) RECEPTORS;
   CA1 REGION
AB High sugar consumption is a risk factor for metabolic disturbances leading to memory impairment. Thus, rats subject to high sucrose intake (HSu) develop a metabolic syndrome and display memory deficits. We now investigated if these HSu-induced memory deficits were associated with metabolic and electrophysiological alterations in the hippocampus. Male Wistar rats were submitted for 9 weeks to a sucrose-rich diet (35% sucrose solution) and subsequently to a battery of behavioral tests; after sacrifice, their hippocampi were collected for ex vivo high-resolution magic angle spinning (HRMAS) metabolic characterization and electrophysiological extracellular recordings in slices. HSu rats displayed a decreased memory performance (object displacement and novel object recognition tasks) and helpless behavior (forced swimming test), without altered locomotion (open field). HRMAS analysis indicated a similar hippocampal metabolic profile of HSu and control rats. HSu rats also displayed no change of synaptic transmission and plasticity (long-term potentiation) in hippocampal Schaffer fibers-CA1 pyramid synapses, but had decreased amplitude of long-term depression in the temporoammonic (TA) pathway. Furthermore, HSu rats had an increased density of inhibitory adenosine A1 receptors (AIR), that translated into a greater potency of AIR in Schaffer fiber synapses, but not in the TA pathway, whereas the endogenous activation of AiR in HSu rats was preserved in the TA pathway but abolished in Schaffer fiber synapses. These results suggest that HSu triggers a hippocampaldependent memory impairment that is not associated with altered hippocampal metabolism but is probably related to modified synaptic plasticity in hippocampal TA synapses (C) 2015 IBRO. Published by Elsevier Ltd. All rights reserved.
C1 [Lemos, C.; Rial, D.; Goncalves, F. Q.; Pires, J.; Silva, H. B.; Matheus, F. C.; Da Silva, A. C.; Marques, J. M.; Rodrigues, R. J.; Jarak, I.; Prediger, R. D.; Carvalho, R. A.; Cunha, R. A.] Univ Coimbra, CNC Ctr Neurosci & Cell Biol, P-3004517 Coimbra, Portugal.
   [Lemos, C.; Carvalho, R. A.] Univ Coimbra, Fac Sci & Technol, P-3004517 Coimbra, Portugal.
   [Rial, D.; Matheus, F. C.; Prediger, R. D.] Univ Fed Santa Catarina, Dept Farmacol, Florianopolis, SC, Brazil.
   [Reis, F.; Pereira, F. C.] Univ Coimbra, Fac Med, Lab Pharmacol & Expt Therapeut, Inst Biomed Imaging & Life Sci IBILI, P-3004517 Coimbra, Portugal.
   [Cunha, R. A.] Univ Coimbra, Fac Med, P-3004517 Coimbra, Portugal.
C3 Universidade de Coimbra; Universidade de Coimbra; Universidade Federal
   de Santa Catarina (UFSC); Universidade de Coimbra; Universidade de
   Coimbra
RP Cunha, RA (corresponding author), Univ Coimbra, CNC Ctr Neurosci & Cell Biol, P-3004517 Coimbra, Portugal.
EM cunharod@gmail.com
RI Pereira, Frederico/AAX-5556-2020; Marques, Joana/AAW-2711-2020;
   Prediger, Rui/AAV-3419-2020; Matheus, Filipe/AAB-9747-2020; Lemos,
   Cristina/HGF-0605-2022; Reis, Flávio/E-7077-2016; Rial,
   Daniel/D-3219-2009; Rodrigues, Ricardo/B-3847-2008; Rial,
   Daniel/C-3595-2013; Silva, Henrique/AAY-4358-2020; Jarak,
   Ivana/D-2243-2011; Carvalho, Rui/A-6661-2010; Cunha,
   Rodrigo/E-7475-2015; Prediger, Rui/C-4036-2013
OI Marques, Joana/0000-0002-7234-9477; Carvalho da Silva, Antonio
   Manuel/0000-0002-8017-104X; Rodrigues, Ricardo/0000-0002-7631-743X;
   Reis, Flavio/0000-0003-3401-9554; Rial, Daniel/0000-0002-2079-7331; C.
   Pereira, Frederico/0000-0002-9381-3320; Silva,
   Henrique/0000-0002-7234-3411; Jarak, Ivana/0000-0002-0129-4114;
   Carvalho, Rui/0000-0003-1820-0353; Matheus, Filipe/0000-0003-3525-5954;
   Pires, Johny/0000-0002-7484-2150; Lemos, Cristina/0000-0003-3182-6289;
   Cunha, Rodrigo/0000-0003-2550-6422; Prediger, Rui/0000-0002-7547-6463;
   Queiroz Goncalves, Francisco/0000-0001-8042-0221
FU Santa Casa da Misericordia; FCT [PTDC/SAU-NMC/114810/2009,
   UID/NEU/04539/2013]; QREN [CENTRO-07-ST24-FEDER-002006]; CAPES-FCT; CNPq
   (Ciencia sem Fronteiras);  [DARPA-09-68-ESR-FP-010]; Fundação para a
   Ciência e a Tecnologia [PTDC/SAU-NMC/114810/2009] Funding Source: FCT
FX We acknowledge Santa Casa da Misericordia, DARPA-09-68-ESR-FP-010, FCT
   (PTDC/SAU-NMC/114810/2009 and UID/NEU/04539/2013), QREN
   (CENTRO-07-ST24-FEDER-002006), CAPES-FCT and CNPq (Ciencia sem
   Fronteiras) for funding and CERMAX (Centro de Ressonancia Magnetica
   Antonio Xavier) for the use of the NMR spectrometer 800 MHz, part of the
   National NMR Facility supported by Fundacao para a Ciencia e a
   Tecnologia (RECI/BBB-BQB/0230/2012). All authors declare no conflict of
   interests.
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NR 66
TC 25
Z9 25
U1 0
U2 14
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4522
EI 1873-7544
J9 NEUROSCIENCE
JI Neuroscience
PD FEB 19
PY 2016
VL 315
BP 196
EP 205
DI 10.1016/j.neuroscience.2015.12.018
PG 10
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA DB2BG
UT WOS:000368312700015
PM 26704636
DA 2025-06-11
ER

PT J
AU Meyer, A
   Vuorinen, A
   Zielinska, AE
   Strajhar, P
   Lavery, GG
   Schuster, D
   Odermatt, A
AF Meyer, Arne
   Vuorinen, Anna
   Zielinska, Agnieszka E.
   Strajhar, Petra
   Lavery, Gareth G.
   Schuster, Daniela
   Odermatt, Alex
TI Formation of Threohydrobupropion from Bupropion Is Dependent on
   11β-Hydroxysteroid Dehydrogenase 1
SO DRUG METABOLISM AND DISPOSITION
LA English
DT Article
ID BETA-HYDROXYSTEROID DEHYDROGENASE; CARBONYL REDUCTION; METABOLIC
   SYNDROME; HUMAN LIVER; TYPE-1; PHARMACOKINETICS; INHIBITION; MICE;
   HYDROXYLATION; ENZYME
AB Bupropion is widely used for treatment of depression and as a smoking-cessation drug. Despite more than 20 years of therapeutic use, its metabolism is not fully understood. While CYP2B6 is known to form hydroxybupropion, the enzyme(s) generating erythro- and threohydrobupropion have long remained unclear. Previous experiments using microsomal preparations and the nonspecific inhibitor glycyrrhetinic acid suggested a role for 11 beta-hydroxysteroid dehydrogenase 1 (11 beta-HSD1) in the formation of both erythro-and threohydrobupropion. 11 beta-HSD1 catalyzes the conversion of inactive glucocorticoids (cortisone, prednisone) to their active forms (cortisol, prednisolone). Moreover, it accepts several other substrates. Here, we used for the first time recombinant 11 beta-HSD1 to assess its role in the carbonyl reduction of bupropion. Furthermore, we applied human, rat, and mouse liver microsomes and a selective inhibitor to characterize species-specific differences and to estimate the relative contribution of 11 beta-HSD1 to bupropion metabolism. The results revealed 11 beta-HSD1 as the major enzyme responsible for threohydrobupropion formation. The reaction was stereoselective and no erythrohydrobupropion was formed. Human liver microsomes showed 10 and 80 times higher activity than rat and mouse liver microsomes, respectively. The formation of erythrohydrobupropion was not altered in experiments with microsomes from 11 beta-HSD1-deficient mice or upon incubation with 11 beta-HSD1 inhibitor, indicating the existence of another carbonyl reductase that generates erythrohydrobupropion. Molecular docking supported the experimental findings and suggested that 11 beta-HSD1 selectively converts R-bupropion to threohydrobupropion. Enzyme inhibition experiments suggested that exposure to bupropion is not likely to impair 11 beta-HSD1-dependent glucocorticoid activation but that pharmacological administration of cortisone or prednisone may inhibit 11 beta-HSD1-dependent bupropion metabolism.
C1 [Meyer, Arne; Strajhar, Petra; Odermatt, Alex] Univ Basel, Dept Pharmaceut Sci, Swiss Ctr Appl Human Toxicol, CH-4056 Basel, Switzerland.
   [Meyer, Arne; Strajhar, Petra; Odermatt, Alex] Univ Basel, Dept Pharmaceut Sci, Div Mol & Syst Toxicol, CH-4056 Basel, Switzerland.
   [Vuorinen, Anna; Schuster, Daniela] Univ Innsbruck, Inst Pharm Pharmaceut Chem, A-6020 Innsbruck, Austria.
   [Vuorinen, Anna; Schuster, Daniela] Univ Innsbruck, Ctr Mol Biosci Innsbruck, A-6020 Innsbruck, Austria.
   [Zielinska, Agnieszka E.; Lavery, Gareth G.] Univ Birmingham, Coll Med & Dent Sci, Sch Clin & Expt Med, Inst Biomed Res,Ctr Endocrinol Diabet & Metab, Birmingham, W Midlands, England.
C3 University of Basel; University of Basel; University of Innsbruck;
   University of Innsbruck; University of Birmingham
RP Odermatt, A (corresponding author), Univ Basel, Dept Pharmaceut Sci, Div Mol & Syst Toxicol, Klingelbergstr 50, CH-4056 Basel, Switzerland.
EM alex.odermatt@unibas.ch
RI Lavery, Gareth/F-9346-2010; Schuster, Daniela/C-1024-2014
OI Odermatt, Alex/0000-0002-6820-2712; Schuster,
   Daniela/0000-0002-9933-8938
FU Swiss National Science Foundation [PDFMP3-127330]; BBSRC David Philips
   fellowship [BB/G023468/1]; Austrian Academy of Sciences; University of
   Innsbruck's Young Talents Grants (Nachwuchsforderung); Erika Cremer
   Habilitation Program of the University of Innsbruck; BBSRC
   [BB/G023468/1] Funding Source: UKRI; Swiss National Science Foundation
   (SNF) [PDFMP3_127330] Funding Source: Swiss National Science Foundation
   (SNF)
FX This work was supported by the Swiss National Science Foundation [Grant
   PDFMP3-127330] (to A.O.); and a BBSRC David Philips fellowship [Grant
   BB/G023468/1] (to G.L.). A.O. has a Chair for Molecular and Systems
   Toxicology by the Novartis Research Foundation. A.V. is supported by a
   Ph.D. grant from the Austrian Academy of Sciences and has received
   financial support from the University of Innsbruck's Young Talents
   Grants (Nachwuchsforderung). D.S. is financed by the Erika Cremer
   Habilitation Program of the University of Innsbruck.
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NR 52
TC 26
Z9 36
U1 0
U2 7
PU AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3995 USA
SN 0090-9556
EI 1521-009X
J9 DRUG METAB DISPOS
JI Drug Metab. Dispos.
PD SEP
PY 2013
VL 41
IS 9
BP 1671
EP 1678
DI 10.1124/dmd.113.052936
PG 8
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 201HQ
UT WOS:000323131700009
PM 23804523
OA Green Published
DA 2025-06-11
ER

PT J
AU Quarta, R
   Martino, G
   Romano, LR
   Lopes, G
   Greco, FF
   Spaccarotella, CAM
   Indolfi, C
   Curcio, A
   Polimeni, A
AF Quarta, Rossella
   Martino, Giovanni
   Romano, Letizia Rosa
   Lopes, Giovanni
   Greco, Francesco Fabio
   Spaccarotella, Carmen Anna Maria
   Indolfi, Ciro
   Curcio, Antonio
   Polimeni, Alberto
TI The Role of Circulating Biomarkers in Patients with Coronary
   Microvascular Disease
SO BIOMOLECULES
LA English
DT Review
DE circulating biomarkers; coronary microvascular dysfunction (CMD);
   coronary flow reserve (CFR); index of microvascular resistance (IMR)
ID C-REACTIVE PROTEIN; ISCHEMIA SYNDROME EVALUATION; CARDIAC SYNDROME-X;
   INFLAMMATORY MARKERS; ENDOTHELIAL-CELLS; OXIDATIVE STRESS;
   ANGINA-PECTORIS; WORKING GROUP; URIC-ACID; DYSFUNCTION
AB Coronary microvascular disease (CMD) comprises a spectrum of conditions characterized by the functional and structural abnormalities of coronary microcirculation, affecting vessels typically smaller than 500 mu m. Despite its clinical significance as a contributor to myocardial ischemia, CMD frequently remains underdiagnosed due to the limitations of current diagnostic approaches. Invasive testing, including coronary reactivity assessment, is considered the gold standard, but it is resource-intensive and not always accessible. Non-invasive methods, such as positron emission tomography (PET) and transthoracic Doppler echocardiography (TTDE), offer alternatives but are limited by varying accuracy and accessibility. Amid these diagnostic challenges, there is increasing interest in circulating biomarkers as adjuncts in CMD evaluation. Biomarkers associated with endothelial dysfunction, inflammation, and oxidative stress, detectable through routine blood tests, may assist in CMD diagnosis, risk stratification, and therapeutic monitoring. These biomarkers can offer insights into CMD pathogenesis and enable early, non-invasive screening to identify patients who may benefit from more invasive investigations. This narrative review examines studies assessing biomarkers in CMD patients with diagnoses confirmed through invasive techniques. Our objective is to focus on circulating biomarkers linked to the invasive evaluation of coronary microcirculation, aiming to advance the understanding of the underlying mechanisms of this prevalent condition and enhance diagnostic accuracy and the clinical management of affected patients.
C1 [Quarta, Rossella; Lopes, Giovanni; Indolfi, Ciro; Curcio, Antonio; Polimeni, Alberto] Univ Calabria, Dept Pharm Hlth & Nutr Sci, I-87036 Arcavacata Di Rende, Italy.
   [Quarta, Rossella; Romano, Letizia Rosa; Curcio, Antonio] Annunziata Hosp, Div Cardiol, I-87100 Cosenza, Italy.
   [Martino, Giovanni; Romano, Letizia Rosa] Magna Graecia Univ Catanzaro, Dept Med & Surg Sci, I-88100 Catanzaro, Italy.
   [Greco, Francesco Fabio; Polimeni, Alberto] Annunziata Hosp, Div Intervent Cardiol, I-87100 Cosenza, Italy.
   [Spaccarotella, Carmen Anna Maria] Univ Naples Federico II, Dept Adv Biomed Sci, Div Cardiol, I-80134 Naples, Italy.
C3 University of Calabria; Magna Graecia University of Catanzaro;
   University of Naples Federico II
RP Curcio, A; Polimeni, A (corresponding author), Univ Calabria, Dept Pharm Hlth & Nutr Sci, I-87036 Arcavacata Di Rende, Italy.; Curcio, A (corresponding author), Annunziata Hosp, Div Cardiol, I-87100 Cosenza, Italy.; Polimeni, A (corresponding author), Annunziata Hosp, Div Intervent Cardiol, I-87100 Cosenza, Italy.
EM antonio.curcio.cardio@unical.it; alberto.polimeni@unical.it
RI Romano, Letizia/KYQ-4427-2024; Spaccarotella, Carmen Anna
   Maria/IAS-0433-2023; Polimeni, Alberto/M-9243-2019; Polimeni,
   Alberto/K-4731-2018
OI Polimeni, Alberto/0000-0002-9166-3031; Curcio,
   Antonio/0000-0003-3213-4436
FU CardioPath program of the Federico II University of Naples, Italy
FX Giovanni Martino, MD, received a research grant from the CardioPath
   program of the Federico II University of Naples, Italy.
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NR 90
TC 0
Z9 0
U1 2
U2 2
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2218-273X
J9 BIOMOLECULES
JI Biomolecules
PD FEB
PY 2025
VL 15
IS 2
AR 177
DI 10.3390/biom15020177
PG 17
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA Y2R3J
UT WOS:001430656100001
PM 40001480
OA gold
DA 2025-06-11
ER

PT J
AU Amano, T
AF Amano, Toshiyasu
TI Late-onset hypogonadism: current methods of clinical diagnosis and
   treatment in Japan
SO ASIAN JOURNAL OF ANDROLOGY
LA English
DT Article; Early Access
DE Aging Male Symptoms scale; alternative medicine; late-onset hypogonadism
   syndrome; testosterone replacement
ID TESTOSTERONE OINTMENT GLOWMIN; SERUM TESTOSTERONE; PROSTATE-CANCER;
   ACTING TESTOSTERONE; REPLACEMENT THERAPY; MEN; EFFICACY; GEL;
   DEFICIENCY; MEDICINE
AB Testosterone affects several organs in the body and is very important for male well-being. Aging men with late-onset hypogonadism (LOH) experience physiologic, psychiatric, and sexual symptoms related to a decline in the serum concentration of testosterone with age. However, it is well-known that the extent of the decline in testosterone concentration does not correlate with the severity of LOH-related symptoms. Therefore, it is difficult to diagnose and treat patients with LOH. In addition, the symptoms, response to testosterone replacement therapy (TRT), and medical insurance coverage differ among ethnicities and countries. The evaluation of testosterone is essential for the diagnosis and treatment of LOH. The effects of testosterone are determined not only by the serum testosterone concentration but also by the androgen receptor sensitivity. A low number of glutamine repeats is indicative of high androgenic activity, and the number shows ethnicity-related differences (fewer in African American than in Caucasian people and more in East Asian people). The diagnosis of LOH is typically made using subjective symptoms and the serum testosterone concentration. The Aging Male Symptoms scale is widely used to evaluate the symptoms. The normal range of total testosterone concentration varies around the world; therefore, clinicians should follow the guidelines of their regional academic society. The principal treatment for LOH is TRT. There are many types of TRT and other treatment strategies are also available. Thus, physicians should treat LOH according to each patient's situation, considering related disorders, such as diabetes, osteoporosis, metabolic syndrome, and depression.
C1 [Amano, Toshiyasu] Nagano Red Cross Hosp, Dept Urol, Nagano 3808528, Japan.
C3 Nagano Red Cross Hospital
RP Amano, T (corresponding author), Nagano Red Cross Hosp, Dept Urol, Nagano 3808528, Japan.
EM t.amano@nagano-rch.jp
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NR 71
TC 0
Z9 0
U1 1
U2 1
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, Maharashtra, INDIA
SN 1008-682X
EI 1745-7262
J9 ASIAN J ANDROL
JI Asian J. Androl.
PD 2025 JAN 28
PY 2025
DI 10.4103/aja2024111
EA JAN 2025
PG 7
WC Andrology; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Urology & Nephrology
GA U2D7E
UT WOS:001409969900001
PM 39887188
OA gold
DA 2025-06-11
ER

PT J
AU Cheng, HS
   Tan, WR
   Low, ZS
   Marvalim, C
   Lee, JYH
   Tan, NS
AF Cheng, Hong Sheng
   Tan, Wei Ren
   Low, Zun Siong
   Marvalim, Charlie
   Lee, Justin Yin Hao
   Tan, Nguan Soon
TI Exploration and Development of PPAR Modulators in Health and Disease: An
   Update of Clinical Evidence
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE clinical trials; metabolic syndrome; type 2 diabetes mellitus; cancer;
   non-alcoholic fatty liver diseases; cardiovascular diseases;
   neurological disorders
ID ACTIVATED-RECEPTOR-GAMMA; PLACEBO-CONTROLLED TRIAL; PRIMARY
   BILIARY-CIRRHOSIS; TYPE-2 DIABETES-MELLITUS; IMPAIRED GLUCOSE-TOLERANCE;
   POLYCYSTIC-OVARY-SYNDROME; INTIMA-MEDIA THICKNESS; PROOF-OF-CONCEPT;
   VENTRICULAR DIASTOLIC FUNCTION; ADVERSE CARDIOVASCULAR EVENTS
AB Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors that govern the expression of genes responsible for energy metabolism, cellular development, and differentiation. Their crucial biological roles dictate the significance of PPAR-targeting synthetic ligands in medical research and drug discovery. Clinical implications of PPAR agonists span across a wide range of health conditions, including metabolic diseases, chronic inflammatory diseases, infections, autoimmune diseases, neurological and psychiatric disorders, and malignancies. In this review we aim to consolidate existing clinical evidence of PPAR modulators, highlighting their clinical prospects and challenges. Findings from clinical trials revealed that different agonists of the same PPAR subtype could present different safety profiles and clinical outcomes in a disease-dependent manner. Pemafibrate, due to its high selectivity, is likely to replace other PPAR alpha agonists for dyslipidemia and cardiovascular diseases. PPAR gamma agonist pioglitazone showed tremendous promises in many non-metabolic disorders like chronic kidney disease, depression, inflammation, and autoimmune diseases. The clinical niche of PPAR beta/delta agonists is less well-explored. Interestingly, dual- or pan-PPAR agonists, namely chiglitazar, saroglitazar, elafibranor, and lanifibranor, are gaining momentum with their optimistic outcomes in many diseases including type 2 diabetes, dyslipidemia, non-alcoholic fatty liver disease, and primary biliary cholangitis. Notably, the preclinical and clinical development for PPAR antagonists remains unacceptably deficient. We anticipate the future design of better PPAR modulators with minimal off-target effects, high selectivity, superior bioavailability, and pharmacokinetics. This will open new possibilities for PPAR ligands in medicine.
C1 [Cheng, Hong Sheng; Marvalim, Charlie; Tan, Nguan Soon] Nanyang Technol Univ Singapore, Sch Biol Sci, 60 Nanyang Dr, Singapore 637551, Singapore.
   [Tan, Wei Ren; Low, Zun Siong; Lee, Justin Yin Hao; Tan, Nguan Soon] Nanyang Technol Univ Singapore, Lee Kong Chian Sch Med, 11 Mandalay Rd, Singapore 308232, Singapore.
C3 Nanyang Technological University; Nanyang Technological University
RP Cheng, HS; Tan, NS (corresponding author), Nanyang Technol Univ Singapore, Sch Biol Sci, 60 Nanyang Dr, Singapore 637551, Singapore.; Tan, NS (corresponding author), Nanyang Technol Univ Singapore, Lee Kong Chian Sch Med, 11 Mandalay Rd, Singapore 308232, Singapore.
EM hscheng@ntu.edu.sg; WTAN074@e.ntu.edu.sg; ZUNSIONG001@e.ntu.edu.sg;
   CMARVALI001@e.ntu.edu.sg; lee.yinhao@ntu.edu.sg; nstan@ntu.edu.sg
RI Cheng, Hong Sheng/AAD-6121-2019; TAN, WEI REN/KHZ-3186-2024; Tan, Nguan
   Soon/A-2220-2011
OI Low, Zun Siong/0000-0001-5335-6826; TAN, WEI REN/0000-0002-5076-0206;
   Cheng, Hong Sheng/0000-0001-9745-7872; Marvalim,
   Charlie/0000-0003-3287-1794; Tan, Nguan Soon/0000-0003-0136-7341
FU Nanyang Technological University Start-Up Grant [M4082040]
FX N.S.T.'s work was supported by Nanyang Technological University Start-Up
   Grant, grant number M4082040.
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NR 331
TC 192
Z9 208
U1 11
U2 54
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD OCT 2
PY 2019
VL 20
IS 20
AR 5055
DI 10.3390/ijms20205055
PG 69
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Biochemistry & Molecular Biology; Chemistry
GA JQ3AZ
UT WOS:000498822800087
PM 31614690
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Pagano, MJ
   De Fazio, A
   Levy, A
   RoyChoudhury, A
   Stahl, PJ
AF Pagano, Matthew J.
   De Fazio, Adam
   Levy, Alison
   RoyChoudhury, Arindam
   Stahl, Peter J.
TI Age, Body Mass Index, and Frequency of Sexual Activity are Independent
   Predictors of Testosterone Deficiency in Men With Erectile Dysfunction
SO UROLOGY
LA English
DT Article
ID CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; HYPOGONADISM; POPULATION;
   PREVALENCE; GUIDELINES; MANAGEMENT; MORTALITY; SOCIETY; SERUM
AB OBJECTIVES To identify clinical predictors of testosterone deficiency (TD) in men with erectile dysfunction (ED), thereby identifying subgroups that are most likely to benefit from targeted testosterone screening.
   METHODS Retrospective review was conducted on 498 men evaluated for ED between January 2013 and July 2014. Testing for TD by early morning serum measurement was offered to all eligible men. Patients with history of prostate cancer or testosterone replacement were excluded. Univariable linear regression was conducted to analyze 19 clinical variables for associations with serum total testosterone (TT), calculated free testosterone (cFT), and TD (T <300 ng/dL or cFT <6.5 ng/dL). Variables significant on univariable analysis were included in multiple regression models.
   RESULTS A total of 225 men met inclusion criteria. Lower TT levels were associated with greater body mass index (BMI), less frequent sexual activity, and absence of clinical depression on multiple regression analysis. TT decreased by 49.5 ng/dL for each 5-point increase in BMI. BMI and age were the only independent predictors of cFT levels on multivariable analysis. Overall, 62 subjects (27.6%) met criteria for TD. Older age, greater BMI, and less frequent sexual activity were the only independent predictors of TD on multiple regression. We observed a 2.2-fold increase in the odds of TD for every 5-point increase in BMI, and a 1.8-fold increase for every 10 year increase in age.
   CONCLUSIONS Men with ED and elevated BMI, advanced age, or infrequent sexual activity appear to be at high risk of TD, and such patients represent excellent potential candidates for targeted testosterone screening. (C) 2016 Elsevier Inc.
C1 [Pagano, Matthew J.] Columbia Univ, Med Ctr, Dept Urol, 161 Ft Washington Ave,11th Floor, New York, NY 10032 USA.
   Columbia Univ, Mailman Sch Publ Hlth, Dept Biostat, New York, NY 10032 USA.
C3 Columbia University; Columbia University
RP Pagano, MJ (corresponding author), Columbia Univ, Med Ctr, Dept Urol, 161 Ft Washington Ave,11th Floor, New York, NY 10032 USA.
EM mjp2147@cumc.columbia.edu
OI Pagano, Matthew/0000-0002-5769-1776
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NR 28
TC 7
Z9 8
U1 0
U2 5
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0090-4295
EI 1527-9995
J9 UROLOGY
JI Urology
PD APR
PY 2016
VL 90
BP 112
EP 118
DI 10.1016/j.urology.2015.12.030
PG 7
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA DI4JT
UT WOS:000373466900041
PM 26743389
DA 2025-06-11
ER

PT J
AU Medici, M
   Visser, WE
   Visser, TJ
   Peeters, RP
AF Medici, Marco
   Visser, W. Edward
   Visser, Theo J.
   Peeters, Robin P.
TI Genetic Determination of the Hypothalamic-Pituitary-Thyroid Axis: Where
   Do We Stand?
SO ENDOCRINE REVIEWS
LA English
DT Review
ID GENOME-WIDE ASSOCIATION; HORMONE RECEPTOR-ALPHA; ANION TRANSPORTING
   POLYPEPTIDE; DEIODINASE THR92ALA POLYMORPHISM; TYPE-2 IODOTHYRONINE
   DEIODINASE; IODINE-DEFICIENT AREAS; SERUM TSH LEVELS;
   INSULIN-RESISTANCE; B-CELL; PHOSPHODIESTERASE 8B
AB For a long time it has been known that both hypo- and hyperthyroidism are associated with an increased risk of morbidity and mortality. In recent years, it has also become clear that minor variations in thyroid function, including subclinical dysfunction and variation in thyroid function within the reference range, can have important effects on clinical endpoints, such as bone mineral density, depression, metabolic syndrome, and cardiovascular mortality. Serum thyroid parameters show substantial inter individual variability, whereas the intraindividual variability lies within a narrow range. This suggests that every individual has a unique hypothalamus-pituitary-thyroid axis setpoint that is mainly determined by genetic factors, and this heritability has been estimated to be 40-60%. Various mutations in thyroid hormone pathway genes have been identified in persons with thyroid dysfunction or altered thyroid function tests. Because these causes are rare, many candidate gene and linkage studies have been performed over the years to identify more common variants (polymorphisms) associated with thyroid (dys)function, but only a limited number of consistent associations have been found. However, in the past 5 years, advances in genetic research have led to the identification of a large number of new candidate genes. In this review, we provide an overview of the current knowledge about the polygenic basis of thyroid (dys)function. This includes new candidate genes identified by genome-wide approaches, what insights these genes provide into the genetic basis of thyroid (dys)function, and which new techniques will help to further decipher the genetic basis of thyroid (dys)function in the near future.
C1 [Medici, Marco; Visser, W. Edward; Visser, Theo J.; Peeters, Robin P.] Erasmus MC, Rotterdam Thyroid Ctr, Dept Internal Med, NL-3015 GE Rotterdam, Netherlands.
C3 Erasmus University Rotterdam; Erasmus MC
RP Medici, M (corresponding author), Erasmus MC, Dept Internal Med, Room Ee 502a,Dr Molewaterpl 50, NL-3015 GE Rotterdam, Netherlands.
EM m.medici@erasmusmc.nl
RI Visser, W./C-4062-2015; Visser, Theo/C-8059-2013; Medici,
   Marco/U-2777-2018; Peeters, Robin/P-3603-2014
OI Peeters, Robin/0000-0001-7732-9371
FU ZonMW VENI Grant [91696017]; Erasmus MC Fellowship
FX This work was supported by a ZonMW VENI Grant (91696017) and an Erasmus
   MC Fellowship (RPP).
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NR 285
TC 71
Z9 70
U1 1
U2 25
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0163-769X
EI 1945-7189
J9 ENDOCR REV
JI Endocr. Rev.
PD APR
PY 2015
VL 36
IS 2
BP 214
EP 244
DI 10.1210/er.2014-1081
PG 31
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA CG2RX
UT WOS:000353123500004
PM 25751422
DA 2025-06-11
ER

PT J
AU Laberge, S
   Gosselin, V
   Lestage, K
   Chagnon, M
   Guimond, C
AF Laberge, Suzanne
   Gosselin, Veronique
   Lestage, Kim
   Chagnon, Miguel
   Guimond, Claude
TI Promotion of Physical Activity by Quebec Primary Care Physicians: What
   Has Changed in the Last Decade?
SO JOURNAL OF PHYSICAL ACTIVITY & HEALTH
LA English
DT Article
DE cross-sectional study; survey; primary prevention; secondary prevention;
   physical activity promotion
ID EXERCISE; IMPLEMENTATION; PRESCRIPTION; PREVENTION; MORTALITY; MEDICINE;
   DISEASE; IMPACT; SPORT
AB Objective: This study aimed to assess the changes in the frequency of physical activity (PA) counseling and in the predictors of primary care PA promotion in Quebec primary care physicians (PCPs) between 2010 and 2020. Methods: In 2010, we conducted a survey among Quebec PCPs. Questions included: frequency of promoting PA to patients, perceived barriers, needs to improve PA promotion practice, frequency of PCPs' PA practice, and sociodemographic information. In 2020, we took over the 2010 questionnaire to document the evolution of the PA promotion practice. Results: The proportion of PCPs discussing PA with their patients significantly increased (P < .05) in 2020 for the following health conditions: depression, low back pain, chronic obstructive pulmonary disease, and cancer; it declined (P < .05) for overweight patients, those with metabolic syndrome, and in primary prevention. Collaboration with PA professionals was the major need identified, and it increased in 2020. PCPs' own practice of PA was a predictor of PA promotion in 2010 (odds ratio = 6.679; P < .001) and in 2020 (odds ratio = 6.679; P < .001). In both 2010 and in 2020, older or more experienced PCPs were more likely to discuss PA with their patients without diagnosed diseases than younger ones or those with less experience. Conclusions: Over the last 10 years, there has been a significant increase in PCPs promoting PA in Quebec; however, it has been mainly oriented toward secondary prevention. It is concerning that PA counseling in primary prevention has declined, notably among younger PCPs. The stronger claim for closer collaboration with kinesiologists suggests that PCPs are in favor of an interprofessional strategy, namely collaboration with PA specialists.
C1 [Laberge, Suzanne; Gosselin, Veronique] Univ Montreal, Fac Med, Sch Kinesiol & Phys Act, Montreal, PQ, Canada.
   [Lestage, Kim] Integrated Hlth & Social Serv Ctr Monteregie Est, Publ Hlth Program RLS Pierre Boucher, Longueuil, PQ, Canada.
   [Chagnon, Miguel] Univ Montreal, Dept Math & Stat, Montreal, PQ, Canada.
   [Guimond, Claude] Federat medecins omnipraticiens Quebec, Westmount, PQ, Canada.
C3 Universite de Montreal; Universite de Montreal
RP Laberge, S (corresponding author), Univ Montreal, Fac Med, Sch Kinesiol & Phys Act, Montreal, PQ, Canada.
EM Suzanne.laberge@umontreal.ca
RI Chagnon, Miguel/ABB-6996-2020
OI Gosselin, Veronique/0000-0002-9644-548X; laberge,
   suzanne/0000-0002-3057-4297
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NR 49
TC 0
Z9 0
U1 0
U2 2
PU HUMAN KINETICS PUBL INC
PI CHAMPAIGN
PA 1607 N MARKET ST, PO BOX 5076, CHAMPAIGN, IL 61820-2200 USA
SN 1543-3080
EI 1543-5474
J9 J PHYS ACT HEALTH
JI J. Phys. Act. Health
PD MAY
PY 2024
VL 21
IS 5
BP 508
EP 518
DI 10.1123/jpah.2023-0379
EA MAR 2024
PG 11
WC Public, Environmental & Occupational Health
WE Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA QE1B3
UT WOS:001186403800001
PM 38490193
OA hybrid
DA 2025-06-11
ER

PT J
AU Ottavi, TP
   Pepper, E
   Bateman, G
   Fiorentino, M
   Brodtmann, A
AF Ottavi, Thomas P.
   Pepper, Elizabeth
   Bateman, Grant
   Fiorentino, Mark
   Brodtmann, Amy
TI Consensus statement for the management of incidentally found brain white
   matter hyperintensities in general medical practice
SO MEDICAL JOURNAL OF AUSTRALIA
LA English
DT Article
DE Cerebrovascular disorders; Dementia; Stroke; Preventive medicine
ID OBSTRUCTIVE SLEEP-APNEA; SMALL VESSEL DISEASE; COGNITIVE IMPAIRMENT;
   METABOLIC SYNDROME; PROGRESSION; PREVALENCE; DEMENTIA; LEUKOARAIOSIS;
   METAANALYSIS; PREVENTION
AB IntroductionThere is a paradigm shift in our understanding of white matter hyperintensities (WMH) found on brain imaging. They were once thought to be a normal phenomenon of ageing and, therefore, warranted no further investigation. However, evidence now suggests these lesions are markers of poor brain and cardiovascular health, portending an increased risk of stroke, cognitive decline, depression and death. Nevertheless, no specific guidelines exist for the management of incidentally found WMH for general medical practitioners and other clinicians ordering brain magnetic resonance imaging scans for diverse clinical indications. Informed by a literature review and expert opinion gleaned from stroke neurologists, medical and imaging specialists, and general practitioners, we present our consensus statement to guide the management of incidentally found WMH in adults. Main recommendationsWhen incidental WMH are found on brain imaging: Perform a detailed history and examination to screen for neurological events.Investigate for potential undiagnosed or undertreated cardiovascular risk factors, especially hypertension and diabetes mellitus.Commence intensive and individualised cardiovascular risk management when risk factors are uncovered.Treat underlying risk factors via accepted guidelines but note that antiplatelet and anticoagulant medications should not be prescribed for incidental WMH in the absence of an alternative indication. Changes to management as a result of this consensus statementA brain health opportunity. We consider the discovery of incidental WMH on brain imaging to represent an opportunity to investigate for common cardiovascular risk factors and to optimise brain health. This can be commenced and monitored by the general practitioner or physician without delay in waiting for an outpatient neurology review.
C1 [Ottavi, Thomas P.; Pepper, Elizabeth; Bateman, Grant; Fiorentino, Mark] John Hunter Hosp, Newcastle Upon Tyne, NSW, Australia.
   [Brodtmann, Amy] Monash Univ, Melbourne, Vic, Australia.
C3 John Hunter Hospital; Monash University
RP Ottavi, TP (corresponding author), John Hunter Hosp, Newcastle Upon Tyne, NSW, Australia.
EM thomas.ottavi@health.nsw.gov.au
RI Bateman, Grant/JTT-6330-2023
OI Brodtmann, Amy/0000-0001-9466-2862; Bateman, Grant/0000-0003-3095-9047;
   Ottavi, Thomas/0000-0002-2116-7251
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NR 54
TC 6
Z9 6
U1 0
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0025-729X
EI 1326-5377
J9 MED J AUSTRALIA
JI Med. J. Aust.
PD SEP 18
PY 2023
VL 219
IS 6
BP 278
EP 284
DI 10.5694/mja2.52079
EA AUG 2023
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA S1UO5
UT WOS:001051010600001
PM 37604652
OA hybrid
DA 2025-06-11
ER

PT J
AU Milajerdi, A
   Jazayeri, S
   Hashemzadeh, N
   Shirzadi, E
   Derakhshan, Z
   Djazayeri, A
   Akhondzadeh, S
AF Milajerdi, Alireza
   Jazayeri, Shima
   Hashemzadeh, Najmeh
   Shirzadi, Elham
   Derakhshan, Zhaleh
   Djazayeri, Abolghassem
   Akhondzadeh, Shahin
TI The effect of saffron (Crocus sativus L.) hydroalcoholic extract
   on metabolic control in type 2 diabetes mellitus: A triple-blinded
   randomized clinical trial
SO JOURNAL OF RESEARCH IN MEDICAL SCIENCES
LA English
DT Article
DE Diabetes mellitus; fasting blood glucose; lipid; metabolic syndrome;
   saffron extract
ID PHYSICAL-ACTIVITY QUESTIONNAIRE; TO-MODERATE DEPRESSION; VASCULAR
   COMPLICATIONS; ALTERNATIVE MEDICINE; AQUEOUS EXTRACT; BLOOD-PRESSURE;
   COMPLEMENTARY; PETAL
AB Background: Metabolic control is a major concern in preventing diabetic complications. Saffron as a natural source of antioxidants could play a role in alleviating diabetes insults. The aim of this study was to investigate effect of saffron hydroalcoholic extract on metabolic control in type 2 diabetes (T2D) mellitus. Materials and Methods: This randomized triple blind study was included 54 T2D patients which randomly received either saffron (Group 1) or placebo (Group 2) twice daily other than routine antidiabetic treatments for 8 weeks. Serum concentration of fasting blood sugar (FBS), 2-h plasma glucose, hemoglobin A1c (HbA1c), total cholesterol, triglyceride (TG), low-density lipoprotein, and high-density lipoprotein were measured as the markers of metabolic control. Anthropometric measures and blood pressure were also measured at the baseline, every 2 weeks during the intervention and the end of the study. Data analyzed using repeated measure analysis of variance test. Results: The baseline metabolic parameters were the same in two group (P > 0.01). FBS serum level significantly decreased within 8 weeks in the saffron group (128.84 +/- 31.86) as compared to the placebo (153.76 +/- 41.23), (P < 0.001). There was no statistical difference in other metabolic parameters such as serum lipids, blood pressure, and HbA1c (P > 0.01). Conclusion: Saffron hydroalcoholic extract may improve blood glucose control by reducing FBS in T2D patients. However, saffron extract has no significant effect on other aspects of diabetic control in diabetic patients.
C1 [Milajerdi, Alireza; Djazayeri, Abolghassem] Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Community Nutr, Tehran 1417863181, Iran.
   [Jazayeri, Shima] Iran Univ Med Sci, Sch Hlth, Dept Nutr, Tehran, Iran.
   [Akhondzadeh, Shahin] Univ Tehran Med Sci, Roozbeh Psychiat Hosp, Psychiat Res Ctr, Tehran, Iran.
   [Hashemzadeh, Najmeh; Shirzadi, Elham; Derakhshan, Zhaleh] Isfahan Diabet Soc, Natanz, Isfahan, Iran.
C3 Tehran University of Medical Sciences; Iran University of Medical
   Sciences; Tehran University of Medical Sciences
RP Djazayeri, A (corresponding author), Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Community Nutr, Tehran 1417863181, Iran.; Akhondzadeh, S (corresponding author), Roozbeh Psychiat Hosp, South Kargar St, Tehran 13337, Iran.
EM jazaiers@tums.ac.ir; s.akhond@neda.net
RI Milajerdi, Alireza/ABB-1854-2020; jazayeri, shima/N-8951-2013;
   Akhondzadeh, Shahin/F-2914-2018
FU Tehran University of Medical Sciences (TUMS)
FX The study was financially supported by the Tehran University of Medical
   Sciences (TUMS). Safrotin and placebo capsules used in this study was
   dedicated by IMPIRAN Co.
CR Abdullaev FI, 2004, CANCER DETECT PREV, V28, P426, DOI 10.1016/j.cdp.2004.09.002
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NR 29
TC 61
Z9 65
U1 0
U2 26
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, Maharashtra, INDIA
SN 1735-1995
EI 1735-7136
J9 J RES MED SCI
JI J. Res. Med. Sci.
PD FEB
PY 2018
VL 23
AR 16
DI 10.4103/jrms.JRMS_286_17
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA FZ1CL
UT WOS:000427313200006
PM 29531568
OA Green Submitted, gold, Green Published
DA 2025-06-11
ER

PT J
AU Dugan, SA
   Everson-Rose, SA
   Karavolos, K
   Avery, EF
   Wesley, DE
   Powell, LH
AF Dugan, Sheila A.
   Everson-Rose, Susan A.
   Karavolos, Kelly
   Avery, Elizabeth F.
   Wesley, Deidre E.
   Powell, Lynda H.
TI Physical Activity and Reduced Intra-abdominal Fat in Midlife
   African-American and White Women
SO OBESITY
LA English
DT Article
ID VISCERAL ADIPOSE-TISSUE; BODY-FAT; ABDOMINAL FAT; RISK-FACTORS;
   PLASMA-LIPOPROTEINS; CARDIOVASCULAR RISK; METABOLIC SYNDROME;
   GLUCOSE-TOLERANCE; AEROBIC EXERCISE; OBESE WOMEN
AB The purpose of our study was to determine whether self-reported physical activity (PA), including recreational, household, and exercise activities, is associated with intra-abdominal fat (IAF) in community-dwelling white and black midlife women. We performed a cross-sectional study of 369 women from the Chicago site of the Study of Women's Health Across the Nation (SWAN) ancillary study, the SWAN Fat Patterning Study. PA level was the independent variable, and IAF, assessed by computerized tomography (CT) scan, was the dependent variable. Measures were obtained at SWAN Fat Patterning Baseline visit between August 2002 and December 2005. Linear regression models explored the association between PA and IAF. The first model included IAF as the outcome and total score PA as the main predictor, adjusting for total percent fat mass, age, and ethnicity. The second model included education, parity, sex hormone-binding globulin ( SHBG) level, and depressive symptoms, measured by Center for Epidemiological Studies-Depression (CES-D) scale. Each 1-point higher total PA score was associated with a 4.0 cm(2) lower amount of IAF (P = 0.004), independent of total percent fat mass, age, ethnicity, SHBG level, educational level, CES-D, and parity. Associations did not differ between white and black women. This study demonstrates a significant negative association between PA and IAF independent of multiple covariates in midlife women. Our findings suggest that motivating white and black women to increase PA during midlife may lessen IAF, which may have a positive impact on subsequent development of diabetes and cardiovascular disease.
C1 [Dugan, Sheila A.; Everson-Rose, Susan A.; Karavolos, Kelly; Avery, Elizabeth F.; Wesley, Deidre E.; Powell, Lynda H.] Rush Univ, Med Ctr, Dept Prevent Med, Chicago, IL 60612 USA.
   [Dugan, Sheila A.] Rush Univ, Med Ctr, Dept Phys Med & Rehabil, Chicago, IL 60612 USA.
   [Everson-Rose, Susan A.] Univ Minnesota, Dept Med, Minneapolis, MN 55455 USA.
   [Everson-Rose, Susan A.] Univ Minnesota, Program Hlth Dispar Res, Minneapolis, MN 55455 USA.
   [Everson-Rose, Susan A.; Powell, Lynda H.] Rush Univ, Med Ctr, Dept Behav Sci, Chicago, IL 60612 USA.
C3 Rush University; Rush University; University of Minnesota System;
   University of Minnesota Twin Cities; University of Minnesota System;
   University of Minnesota Twin Cities; Rush University
RP Dugan, SA (corresponding author), Rush Univ, Med Ctr, Dept Prevent Med, Chicago, IL 60612 USA.
EM Sheila_Dugan@rush.edu
RI Everson-Rose, Susan/L-7582-2017
OI Everson-Rose, Susan/0000-0002-9839-2537
FU National Institutes of Health (NIH), Department of Health and Human
   Services, through the National Institute on Aging (NIA); National
   Institute of Nursing Research (NINR); NIH Office of Research on Women's
   Health (ORWH) [NR004061, AG012505, AG012535, AG012531, AG012539,
   AG012546, AG012553, AG012554, AG012495]; National Heart, Lung and Blood
   Institute [HL067128]; Charles J. and Margaret Roberts Trust
FX The Study of Women's Health Across the Nation (SWAN) has grant support
   from the National Institutes of Health (NIH), Department of Health and
   Human Services, through the National Institute on Aging (NIA), the
   National Institute of Nursing Research (NINR), and the NIH Office of
   Research on Women's Health (ORWH) (grants NR004061; AG012505, AG012535,
   AG012531, AG012539, AG012546, AG012553, AG012554, AG012495). The SWAN
   Fat Patterning Study is supported by the National Heart, Lung and Blood
   Institute (grant HL067128) and the Charles J. and Margaret Roberts
   Trust. The content of this manuscript is solely the responsibility of
   the authors and does not necessarily represent the official views of the
   NIA, NINR, ORWH, or the NIH. Clinical Center: University of Michigan,
   Ann Arbor-MaryFran Sowers, PI; Massachusetts General Hospital, Boston,
   MA-Robert Neer, PI 1994-1999; Joel Finkelstein, PI 1999-present; Rush
   University, Rush University Medical Center, Chicago, IL-Lynda Powell, PI
   1994-2009; Howard Kravitz, PI 2009; University of California,
   Davis/Kaiser-Ellen Gold, PI; University of California, Los Angeles-Gail
   Greendale, PI; University of Medicine and Dentistry-New Jersey Medical
   School, Newark-Gerson Weiss, PI 1994-2004; Nanette Santoro, PI
   2004-present; and the University of Pittsburgh, Pittsburgh, PA-Karen
   Matthews, PI. NIH Program Office: National Institute on Aging, Bethesda,
   MD-Marcia Ory 1994-2001; Sherry Sherman 1994-present; National Institute
   of Nursing Research, Bethesda, MD-Program Officers. Central Laboratory:
   University of Michigan, Ann Arbor-Daniel McConnell ( Central Ligand
   Assay Satellite Services). Coordinating Center: New England Research
   Institutes, Watertown, MA-Sonja McKinlay, PI 1995-2001; University of
   Pittsburgh, Pittsburgh, PA-Kim Sutton-Tyrrell, PI 2001-present. Steering
   Committee: Chris Gallagher, Chair; Susan Johnson, Chair. We thank the
   study staff at each site and all the women who participated in SWAN.
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NR 39
TC 22
Z9 26
U1 2
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1930-7381
EI 1930-739X
J9 OBESITY
JI Obesity
PD JUN
PY 2010
VL 18
IS 6
BP 1260
EP 1265
DI 10.1038/oby.2009.396
PG 6
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 600RQ
UT WOS:000278005300030
PM 19876007
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Alenazi, AM
   Obaidat, SM
   Alshehri, MM
   Alothman, S
   Gray, C
   Rucker, J
   Waitman, LR
   Kluding, PM
AF Alenazi, Aqeel M.
   Obaidat, Sakher M.
   Alshehri, Mohammed M.
   Alothman, Shaima
   Gray, Corey
   Rucker, Jason
   Waitman, Lemuel R.
   Kluding, Patricia M.
TI Type 2 Diabetes Affects Joint Pain Severity in People with Localized
   Osteoarthritis: A Retrospective Study
SO PAIN MEDICINE
LA English
DT Article
DE Pain Intensity; Glycemic Level; Osteoarthritis
ID KNEE OSTEOARTHRITIS; METABOLIC SYNDROME; ASSOCIATION; MELLITUS;
   INTENSITY
AB Objective. To examine the association between type 2 diabetes (T2D) and pain severity in people with localized osteoarthritis (OA) and to explore the association between glycemic control, measured by hemoglobin = (Hb=) level, and pain severity in people with localized OA and T2D. Design. Retrospective study. Setting. A tertiary medical center. Subjects. Data from 819 patients (mean age = 65.0869.77 years, 54.3% women) were used. Methods. Patients were grouped to localized OA only (N = 671) and localized OA+T2D (N = 148) based on diagnosis codes. An index date was set as the first diagnosis date of localized OA and linked to pain severity, measured by numeric rating scale from 0 to 10. HbA1c values were obtained for patients with T2D within six months of the index date. Multiple linear regression was used. Results. After controlling for age, gender, body mass index (BMI); diagnoses of depression, hypertension, dyslipidemia; OA locations; and medication list (+/- 90 days of the index date), T2D was significantly associated with increased pain severity (B = 1.07, 95% confidence interval [CI] = 0.25 to 1.88, P = 0.014). For patients with T2D and localized OA with available data for Hb= (N = 87), the results showed that an increased Hb= value was significantly associated with higher pain severity (B = 0.36, 95% CI = 0.036 to 0.67, P = 0.029) after controlling for age, gender, BMI, medications, and OA locations. Conclusion. T2D was associated with higher pain severity in people with localized OA, and poor glycemic control was associated with higher pain severity in people with localized OA+T2D. Clinicians should emphasize that better HbA1c control might help with pain management in people with T2D and OA.
C1 [Alenazi, Aqeel M.] Prince Sattam Bin Abdulaziz Univ, Dept Rehabil Sci & Phys Therapy, Alkharj, Saudi Arabia.
   [Alenazi, Aqeel M.; Obaidat, Sakher M.; Alshehri, Mohammed M.; Alothman, Shaima; Gray, Corey; Rucker, Jason; Kluding, Patricia M.] Univ Kansas, Med Ctr, Dept Phys Therapy & Rehabil Sci, Kansas City, KS 66103 USA.
   [Obaidat, Sakher M.] Hashemite Univ, Dept Rehabil Sci, Zarqa, Jordan.
   [Alshehri, Mohammed M.] Jazan Univ, Dept Rehabil Sci, Jazan, Saudi Arabia.
   [Waitman, Lemuel R.] Univ Kansas, Med Ctr, Dept Internal Med, Kansas City, KS 66103 USA.
C3 Prince Sattam Bin Abdulaziz University; University of Kansas; University
   of Kansas Medical Center; Hashemite University; Jazan University;
   University of Kansas; University of Kansas Medical Center
RP Alenazi, AM (corresponding author), Prince Sattam Bin Abdulaziz Univ, Coll Appl Med Sci, Dept Phys Therapy & Rehabil Sci, Alkharj 11942, Saudi Arabia.
EM aqeelalenazi.pt@gmail.com
RI Alothman, Shaima/AAR-9567-2021; Obaidat, Sakher/AFL-7909-2022; Alenazi,
   Aqeel/L-3102-2019; Kluding, Patricia/D-1617-2016; Alshehri,
   Mohammed/AFM-1005-2022
OI Alenazi, Aqeel/0000-0002-2641-8339; Alothman,
   Shaima/0000-0003-2739-0929; Obaidat, Sakher/0000-0001-9992-8666;
   Alshehri, Mohammed/0000-0003-0028-0957
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NR 25
TC 14
Z9 15
U1 0
U2 3
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1526-2375
EI 1526-4637
J9 PAIN MED
JI Pain Med.
PD MAY
PY 2020
VL 21
IS 5
BP 1025
EP 1031
DI 10.1093/pm/pnz299
PG 7
WC Anesthesiology; Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Anesthesiology; General & Internal Medicine
GA NJ2XZ
UT WOS:000565912900017
PM 31710675
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Lin, F
   Friedman, E
   Quinn, J
   Chen, DG
   Mapstone, M
AF Lin, Feng
   Friedman, Elliot
   Quinn, Jill
   Chen, Ding-Geng (Din)
   Mapstone, Mark
TI Effect of leisure activities on inflammation and cognitive function in
   an aging sample
SO ARCHIVES OF GERONTOLOGY AND GERIATRICS
LA English
DT Article
DE Physical activities; Mental activities; Cardiovascular disease risk
   factors; Inflammatory markers; Cognition
ID C-REACTIVE PROTEIN; METABOLIC SYNDROME; DEMENTIA; BRAIN; RISK;
   ASSOCIATION; DEPRESSION; IMPAIRMENT; TELEPHONE; DISEASE
AB Cardiovascular disease risk factors (CVDRFs) increase the risk of dementia. The purpose of this study was to examine whether leisure activities (mental, physical, and social activities) modified the effect of CVDRFs on inflammatory markers and cognitive function in middle and old age. A secondary-data analysis study was conducted using data from 405 middle-age participants (40-59 years) and 342 old-age participants (60-84 years) who participated in the Survey of Midlife Development in the United States (MIDUS). CVDRFs were obtained from a combination of self-report medical history and blood-based biomarkers. Three CVDRF groups (<= 1, 2, and >= 3 CVDRFs) were identified. More CVDRFs were significantly associated with higher levels of inflammatory markers in both age groups, and associated with lower levels of executive function (EF) in the old age group. CVDRFs were not related to the frequency of leisure activities in either age group. After controlling for covariates, higher levels of physical activities were significantly associated with lower levels of inflammatory markers, and higher levels of mental activities were associated with higher levels of cognitive function. In the old age group, physical activities also moderated the effect of CVDRFs on episodic memory (EM), and mental activities moderated the effect of CVDRFs on interleukin-6 (IL-6). Multiple CVDRFs may be associated with poorer cognitive function and higher inflammatory markers, but middle-age and older adults with CVDRFs may not engage in frequent physical and cognitive activities that may be protective. It is important to develop strategies to facilitate engagement in these activities from midlife. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
C1 [Lin, Feng; Quinn, Jill; Chen, Ding-Geng (Din)] Univ Rochester, Sch Nursing, Rochester, NY 14642 USA.
   [Friedman, Elliot] Univ Wisconsin Madison, Inst Aging, Madison, WI USA.
   [Chen, Ding-Geng (Din)] Univ Rochester, Sch Med & Dent, Dept Biostat & Computat Biol, Rochester, NY 14642 USA.
   [Mapstone, Mark] Univ Rochester, Sch Med & Dent, Dept Neurol, Rochester, NY 14642 USA.
C3 University of Rochester; University of Wisconsin System; University of
   Wisconsin Madison; University of Rochester; University of Rochester
RP Lin, F (corresponding author), Univ Rochester, Sch Nursing, Helen Wood Hall,601 Elmwood Ave, Rochester, NY 14642 USA.
EM vankee_lin@urmc.rochester.edu
RI Chen, Ding-Geng/GRR-2103-2022; Friedman, Elliot/AAT-2585-2020; Mapstone,
   Mark/KYQ-0983-2024
OI Lin, Feng Vankee/0000-0003-1945-0362; Chen,
   Ding-Geng/0000-0002-3199-8665
FU National Institute on Aging [P01-AG020166]
FX MIDUS II was supported by from the National Institute on Aging
   (P01-AG020166) to conduct a longitudinal follow-up of the MIDUS (Midlife
   in the U.S.) investigation.
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NR 40
TC 20
Z9 24
U1 0
U2 21
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0167-4943
EI 1872-6976
J9 ARCH GERONTOL GERIAT
JI Arch. Gerontol. Geriatr.
PD MAY-JUN
PY 2012
VL 54
IS 3
BP E398
EP E404
DI 10.1016/j.archger.2012.02.002
PG 7
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA 928DB
UT WOS:000302959400023
PM 22377120
OA Green Accepted, Green Published
DA 2025-06-11
ER

PT J
AU Giugliano, F
   Maiorino, M
   Bellastella, G
   Gicchino, M
   Giugliano, D
   Esposito, K
AF Giugliano, F.
   Maiorino, M.
   Bellastella, G.
   Gicchino, M.
   Giugliano, D.
   Esposito, K.
TI Determinants of erectile dysfunction in type 2 diabetes
SO INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH
LA English
DT Article
DE epidemiology; erectile dysfunction; type 2 diabetes; glycemic control;
   metabolic comorbidities
ID LIFE-STYLE CHANGES; RISK-FACTORS; MEN; ASSOCIATION; PREVALENCE;
   PREDICTORS; HYPERGLYCEMIA; POPULATION; MELLITUS
AB This study was designed to evaluate the prevalence and correlates of ED in a population of diabetic men. Consecutive patients with type 2 diabetes were recruited among outpatients regularly attending Diabetes Clinics. Inclusion criteria for the initial selection of patients were a diagnosis of type 2 diabetes for at least 6 months but less than 10 years, age 35-70 years, body mass index (BMI) of 24 or higher, HbA1c of 6.5% or higher: a total of 555 (90.8%) of the 611 men were analyzed in this study. ED was assessed by the IIEF-5 instrument. Approximately, 6 in 10 men in our sample of diabetic men had varying degrees of erectile dysfunction: mild 9%, mild to moderate 11.2%, moderate 16.9% and severe 22.9%. The prevalence of severe ED increased with age. Higher hemoglobin A1c (HbA1c) levels were associated with ED; similarly, the presence of metabolic syndrome, hypertension, atherogenic dyslipidemia (low levels of HDL-cholesterol and high levels of triglycerides) and depression was associated with ED. Physical activity was protective of ED; men with higher levels of physical activity were 10% less likely to have ED as compared with those with the lowest level. In conclusion, among subjects with type 2 diabetes glycemic control and other metabolic covariates were associated with ED risk, whereas higher level of physical activity was protective. These results encourage the implementation of current medical guidelines that place intensive lifestyle changes as the first step of the management of type 2 diabetes. International Journal of Impotence Research (2010) 22, 204-209; doi: 10.1038/ijir.2010.1; published online 11 February 2010
C1 [Maiorino, M.; Bellastella, G.; Gicchino, M.; Giugliano, D.; Esposito, K.] Univ Naples 2, Dept Geriatr & Metab Dis, Div Diabetol & Metab Dis, Naples, Italy.
   [Giugliano, F.] Univ Naples 2, Dept Geriatr & Metab Dis, Div Urol, Naples, Italy.
C3 Universita della Campania Vanvitelli; Universita della Campania
   Vanvitelli
RP Esposito, K (corresponding author), Univ Naples 2, Dept Geriatr & Metab Dis, Div Diabetol & Metab Dis, Naples, Italy.
EM Katherine.esposito@unina2.it
RI Esposito, Katherine/AHE-2564-2022; Maiorino, Maria Ida/AHE-9986-2022;
   Maiorino, Maria Ida/K-3264-2016
OI Giugliano, Dario/0000-0002-9377-873X; Maiorino, Maria
   Ida/0000-0003-4659-7546; Gicchino, Maurizio/0000-0002-2976-7948
CR Al-Hunayan A, 2007, BJU INT, V99, P130, DOI 10.1111/j.1464-410X.2006.06550.x
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NR 36
TC 118
Z9 122
U1 0
U2 5
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0955-9930
EI 1476-5489
J9 INT J IMPOT RES
JI Int. J. Impot. Res.
PD MAY-JUN
PY 2010
VL 22
IS 3
BP 204
EP 209
DI 10.1038/ijir.2010.1
PG 6
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 595BZ
UT WOS:000277587000007
PM 20147958
DA 2025-06-11
ER

PT J
AU Hallit, S
   Saade, S
   Zeidan, RK
   Iskandar, K
   Kheir, N
   Youssef, L
   Costantine, R
   Hallit, R
   Salameh, P
AF Hallit, Souheil
   Saade, Sylvia
   Zeidan, Rouba Karen
   Iskandar, Katia
   Kheir, Nelly
   Youssef, Lara
   Costantine, Rachelle
   Hallit, Rabih
   Salameh, Pascale
TI Factors associated with undiagnosed type II diabetes mellitus,
   undiagnosed impaired fasting glucose and these patients' quality of life
   in Lebanon
SO JOURNAL OF PUBLIC HEALTH
LA English
DT Article
DE knowledge; Lebanon; quality of life; undiagnosed diabetes; undiagnosed
   impaired fasting glucose
ID METABOLIC SYNDROME; PHYSICAL-ACTIVITY; HIGH PREVALENCE; HEALTH-STATUS;
   HIGH-RISK; POPULATION; MANAGEMENT; COMPLICATIONS; DEPRESSION; MORTALITY
AB Objective To assess the association between undiagnosed impaired fasting glucose (UIFG) and diabetes (UD), their risk factors and the patients' knowledge about diabetes and their quality of life (QOL).
   Methods A cross-sectional study was conducted between May and September 2017 in four laboratories enrolling 495 patients. We used the Diabetes Knowledge and SF-12 questionnaires to assess the patients' knowledge about diabetes and QOL. This study meets the Wilson and Jungner criteria for disease screening.
   Results A higher knowledge score (ORa = 0.85) was significantly associated with the absence of diabetes compared to UPD, whereas an increased age (ORa = 1.2) and a positive family history of diabetes (ORa = 1.81) were significantly associated with higher odds of UPD. An increased knowledge score (ORa = 0.55) was significantly associated with an absence of diabetes compared to UD, whereas an increased BMI (ORa = 1.40) and an increased age (ORa = 1.07) were associated with increased odds of having UD.
   UD (Beta = -5.799) was significantly associated with decreased total physical component QOL score, whereas increased diabetes knowledge score (Beta = 0.415) was significantly associated with increased physical QOL. A higher diabetes knowledge score (Beta = 0.459) were associated with increased mental QOL.
   Conclusion Seeing the relatively high percentage of UD and UIFG, we propose that screening should be considered and subject to proper assessment in the light of the findings of this study.
C1 [Hallit, Souheil; Hallit, Rabih] Holy Spirit Univ Kaslik USEK, Fac Med & Med Sci, Jounieh, Lebanon.
   [Hallit, Souheil; Zeidan, Rouba Karen; Iskandar, Katia; Salameh, Pascale] Inspect LB Inst Natl Sante Publ Epidemiol Clin &, Beirut, Lebanon.
   [Saade, Sylvia] Lebanese Int Univ, Sch Pharm, Beirut, Lebanon.
   [Saade, Sylvia] Amer Univ Sci & Technol, Fac Hlth Sci, Beirut, Lebanon.
   [Zeidan, Rouba Karen] Lebanese Univ, Fac Publ Hlth, Fanar, Lebanon.
   [Zeidan, Rouba Karen] Lebanese Univ, Fac Publ Hlth, Ctr Res Publ Hlth, Pharmacoepidemiol Surveillance Unit,CERIPH, Fanar, Lebanon.
   [Iskandar, Katia] INSERM, EQUITY, Equipe 5, Toulouse, France.
   [Kheir, Nelly] Univ St Famille, Fac Pedag, Batroun, Lebanon.
   [Youssef, Lara] Notre Dame Univ, Dept Nursing & Hlth Sci, Zouk, Lebanon.
   [Costantine, Rachelle] Holy Spirit Univ Kaslik USEK, Dept Agron Sci, Jounieh, Lebanon.
   [Salameh, Pascale] Lebanese Univ, Fac Med, Beirut, Lebanon.
   [Salameh, Pascale] Lebanese Univ, Fac Pharm, Beirut, Lebanon.
C3 American University of Science & Technology - Lebanon; Lebanese
   University; Lebanese University; Institut National de la Sante et de la
   Recherche Medicale (Inserm); Notre Dame University Lebanon; Lebanese
   University; Lebanese University
RP Hallit, S (corresponding author), Holy Spirit Univ Kaslik USEK, Fac Med & Med Sci, Jounieh, Lebanon.; Hallit, S (corresponding author), Inspect LB Inst Natl Sante Publ Epidemiol Clin &, Beirut, Lebanon.
EM souheilhallit@hotmail.com
RI Youssef, lara/HCH-6094-2022; ISKANDAR, Katia/AAA-1612-2021; Salameh,
   Pascale/F-9676-2011; Hallit, Souheil/R-6727-2018
OI Salameh, Pascale/0000-0002-4780-0772; Hallit,
   Souheil/0000-0001-6918-5689; Youssef, Lara/0000-0003-3259-0706;
   ISKANDAR, Katia/0000-0001-5544-6681; Zeidan, Rouba
   Karen/0000-0003-3041-1196
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NR 63
TC 4
Z9 4
U1 0
U2 1
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1741-3842
EI 1741-3850
J9 J PUBLIC HEALTH-UK
JI J. Public Health
PD SEP
PY 2020
VL 42
IS 3
BP 550
EP 560
DI 10.1093/pubmed/fdz051
PG 11
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA OW8AM
UT WOS:000593102400044
PM 31162589
DA 2025-06-11
ER

PT J
AU Kajanoja, J
   Karukivi, M
   Scheinin, NM
   Tuulari, JJ
   Ahrnberg, H
   Karlsson, L
   Karlsson, H
AF Kajanoja, Jani
   Karukivi, Max
   Scheinin, Noora M.
   Tuulari, Jetro J.
   Ahrnberg, Hanna
   Karlsson, Linnea
   Karlsson, Hasse
TI Alexithymia, body mass index and gestational diabetes in pregnant women
   - FinnBrain birth cohort study
SO JOURNAL OF PSYCHOSOMATIC RESEARCH
LA English
DT Article
DE Alexithymia; Gestational diabetes; Overweight; Psychosomatics
ID METABOLIC SYNDROME; RISK-FACTOR; OBESITY; SCALE; PERSONALITY;
   DEPRESSION; PREVALENCE; DIMENSIONS; DISORDERS; STABILITY
AB Objective: Overweight, obesity, and associated problems in metabolic health are an increasing public health concern. Personality traits and emotional processing styles may play a role in the regulation of food intake and reward. Alexithymia is a personality construct involving difficulties in identifying and expressing emotions and has been previously associated with eating disorders and metabolic problems. We examined associations between alexithymia dimensions, Body Mass Index (BMI) and gestational diabetes in pregnant women.
   Methods: The participants were 1660 pregnant women living in Finland from the FinnBrain Birth Cohort Study. We investigated the associations between alexithymia and its dimensions as measured by the Toronto Alexithymia Scale (TAS-20), overweight, and gestational diabetes. The effects of age, education, and depressive symptoms were controlled for using hierarchical regression analysis.
   Results: Alexithymic individuals had a higher prevalence of overweight compared to those with low or moderate levels of alexithymia (66.0% vs. 34.8%, OR 3.6, adjusted OR 3.6, CI95% 1.9-6.8, p < .001). The dimension of Externally Oriented Thinking (EOT) accounted for this association. Compared to the lowest quartile, women in the highest EOT quartile had a higher BMI (24.3 vs. 25.6, p < .001), and a higher prevalence of overweight [adjusted OR 1.94, CI95% 1.43-2.62, p < .001] and gestational diabetes [OR 1.75, CI95% 1.19-2.55, p = .005].
   Conclusions: Alexithymia, and especially its dimension of EOT is associated with overweight and gestational diabetes in pregnant women. Future studies should clarify causality and examine potential mechanisms and associations with pregnancy outcomes and fetal health.
C1 [Kajanoja, Jani; Karukivi, Max; Scheinin, Noora M.; Tuulari, Jetro J.; Ahrnberg, Hanna; Karlsson, Linnea; Karlsson, Hasse] Univ Turku, Dept Psychiat, Turku, Finland.
   [Kajanoja, Jani; Karukivi, Max; Scheinin, Noora M.; Tuulari, Jetro J.; Ahrnberg, Hanna; Karlsson, Linnea; Karlsson, Hasse] Turku Univ Hosp, Turku, Finland.
   [Karukivi, Max] Satakunta Hosp Dist, Unit Adolescent Psychiat, Pori, Finland.
   [Karlsson, Linnea] Univ Turku, Dept Child Psychiat, Turku, Finland.
   [Kajanoja, Jani; Karukivi, Max; Scheinin, Noora M.; Tuulari, Jetro J.; Ahrnberg, Hanna; Karlsson, Linnea; Karlsson, Hasse] Univ Turku, FinnBrain Birth Cohort Study, Turku, Finland.
   [Tuulari, Jetro J.] Univ Turku, Turku Coll Sci & Med, Turku, Finland.
C3 University of Turku; University of Turku; University of Turku;
   University of Turku; University of Turku
RP Kajanoja, J (corresponding author), Lemminkaisenkatu 3, Turun 20014, Finland.
EM jani.kajanoja@utu.fi
RI Tuulari, Jetro/ABB-8747-2020; Karlsson, Linnea/AAI-5959-2020
OI Karukivi, Max/0000-0002-8478-3051; Karlsson, Linnea/0000-0002-4725-0176;
   Tuulari, Jetro/0000-0002-1797-8000; Karlsson, Hasse/0000-0002-4992-1893
FU Finnish Cultural Foundation Satakunta Regional Fund; Signe and Ane
   Gyllenberg Foundation; Turku University Foundation; Jane and Aatos Erkko
   Foundation; Academy of Finland [134950, 253270, 287908]; Finnish State
   Grants for Clinical Research (ERVA) [P3003, P3498, P3654]
FX We wish to thank the Finnish Cultural Foundation Satakunta Regional
   Fund, Signe and Ane Gyllenberg Foundation, Turku University Foundation,
   Jane and Aatos Erkko Foundation, and Academy of Finland (Grant number
   287908) for funding this study. In addition, the FinnBrain Birth Cohort
   Study has received funding for this part of the project from the Academy
   of Finland (Grant numbers 134950 and 253270) and Finnish State Grants
   for Clinical Research (ERVA project numbers P3003, P3498, and P3654).
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NR 61
TC 5
Z9 5
U1 1
U2 8
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-3999
EI 1879-1360
J9 J PSYCHOSOM RES
JI J. Psychosomat. Res.
PD SEP
PY 2019
VL 124
AR 109742
DI 10.1016/j.jpsychores.2019.109742
PG 6
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA IT6TQ
UT WOS:000483008100008
PM 31443801
DA 2025-06-11
ER

PT J
AU Pi-Sunyer, X
AF Pi-Sunyer, Xavier
TI The Medical Risks of Obesity
SO POSTGRADUATE MEDICINE
LA English
DT Article
DE cancer; cardiovascular disease; diabetes; obesity; comorbidity;
   mortality
ID BODY-MASS INDEX; FATTY LIVER-DISEASE; RADIOGRAPHIC KNEE OSTEOARTHRITIS;
   DIETARY WEIGHT-LOSS; MIDDLE-AGED MEN; METABOLIC SYNDROME;
   CARDIOVASCULAR-DISEASE; DIABETES-MELLITUS; ACUTE-PANCREATITIS; ECONOMIC
   CONSEQUENCES
AB Obesity is at epidemic proportions in the United States and in other developed and developing countries. The prevalence of obesity is increasing not only in adults, but especially among children and adolescents. In the United States in 2003 to 2004, 17.1% of children and adolescents were overweight, and 32.2% of adults were obese. Obesity is a significant risk factor for and contributor to increased morbidity and mortality, most importantly from cardiovascular disease (CVD) and diabetes, but also from cancer and chronic diseases, including osteoarthritis, liver and kidney disease, sleep apnea, and depression. The prevalence of obesity has increased steadily over the past 5 decades, and obesity may have a significant impact on quality-adjusted life years. Obesity is also strongly associated with an increased risk of all-cause mortality as well as cardiovascular and cancer mortality. Despite the substantial effects of obesity, weight loss can result in a significant reduction in risk for the majority of these comorbid conditions. Those comorbidities most closely linked to obesity must be identified to increase awareness of potential adverse Outcomes. This will allow health care professionals to identify and implement appropriate interventions to reduce patient risk and mortality. A systematic search strategy was used to identify published literature between 1995 and 2008 that reported data from prospective longitudinal studies of obesity and comorbid medical conditions. This article will review evidence for significant associations of obesity with comorbidities to provide information useful for optimal patient management.
C1 Columbia Univ, Div Endocrinol Diabet & Nutr, St Lukes Roosevelt Hosp Ctr, New York, NY 10025 USA.
C3 Columbia University; Mount Sinai St. Luke's; Mount Sinai West
RP Pi-Sunyer, X (corresponding author), Columbia Univ, Div Endocrinol Diabet & Nutr, St Lukes Roosevelt Hosp Ctr, 1111 Amsterdam Ave,Room 1020, New York, NY 10025 USA.
EM fxp1@columbia.edu
FU Amylin Pharmaceutics, Inc.
FX The author would like to acknowledge the assistance of Richard S. Perry,
   PharmD in the preparation of this manuscript, which was funded by Amylin
   Pharmaceutics, Inc.
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NR 94
TC 636
Z9 645
U1 1
U2 50
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0032-5481
EI 1941-9260
J9 POSTGRAD MED
JI Postgrad. Med.
PD NOV
PY 2009
VL 121
IS 6
BP 21
EP 33
DI 10.3810/pgm.2009.11.2074
PG 13
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 527LY
UT WOS:000272369800003
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Mishina, AI
   Bakoev, SY
   Oorzhak, AY
   Keskinov, AA
   Kabieva, SS
   Korobeinikova, AV
   Yudin, VS
   Bobrova, MM
   Shestakov, DA
   Makarov, VV
   Getmantseva, LV
AF Mishina, A. I.
   Bakoev, S. Y.
   Oorzhak, A. Y.
   Keskinov, A. A.
   Kabieva, Sh. Sh.
   Korobeinikova, A. V.
   Yudin, V. S.
   Bobrova, M. M.
   Shestakov, D. A.
   Makarov, V. V.
   Getmantseva, L. V.
TI Search for signals of positive selection of circadian rhythm genes
   PER1, PER2, PER3 in different human populations
SO VAVILOVSKII ZHURNAL GENETIKI I SELEKTSII
LA English
DT Article
DE populations; SNP; adaptation; PER1; PER2; PER3
ID GENE PER2; POLYMORPHISM; ASSOCIATION; CLOCK; SLEEP; GENOME; ADAPTATION;
   SIGNATURES
AB The diversity of geographically distributed human populations shows considerable variation in external and internal traits of individuals. Such differences are largely attributed to genetic adaptation to various environmental influences, which include changes in climatic conditions, variations in sleep and wakefulness, dietary variations, and others. Whole-genome data from individuals of different populations make it possible to determine the specific genetic sites responsible for adaptations and to further understand the genetic structure underlying human adaptive characteristics. In this article, we searched for signals of single nucleotide polymorphisms (SNPs) under selection pressure in people of different populations. To identify selection signals in different population groups, the PER1, PER2 and PER3 genes that are involved in the coordination of thermogenic functions and regulation of circadian rhythms, which is directly reflected in the adaptive abilities of the organism, were investigated. Data were analyzed using publicly available data from the 1000 Genomes Project for 23 populations. The Extended Haplotype Homozygosity Score statistical method was chosen to search for traces of selection. The comparative analysis performed identified points subject to selection pressure. The SNPs were annotated through the GWAS catalog and manually by analyzing Internet resources. This study suggests that living conditions, climate, and other external factors directly influence the genetic structure of populations and vary across races and geographic locations. In addition, many of the selection variants in the PER1, PER2, PER3 genes appear to regulate biological processes that are associated with major modern diseases, including obesity, cancer, metabolic syndrome, bipolar personality disorder, depression, rheumatoid arthritis, diabetes mellitus, lupus erythematosus, stroke and Alzheimer's disease, making them extremely interesting targets for further research aimed at identifying the genetic causes of human disease.
C1 [Mishina, A. I.; Bakoev, S. Y.; Oorzhak, A. Y.; Keskinov, A. A.; Kabieva, Sh. Sh.; Korobeinikova, A. V.; Yudin, V. S.; Bobrova, M. M.; Shestakov, D. A.; Makarov, V. V.; Getmantseva, L. V.] Fed Med Biol Agcy, Ctr Strateg Planning Management Biomed Hlth Risks, Moscow, Russia.
RP Mishina, AI (corresponding author), Fed Med Biol Agcy, Ctr Strateg Planning Management Biomed Hlth Risks, Moscow, Russia.
EM arinamishina32@yandex.ru
RI Mishina, Arina/AAV-3810-2021; Siroj, Bakoev/AAN-6205-2021; Keskinov,
   Anton/KRQ-4225-2024
OI Kabieva, Shuanat/0009-0004-9610-0889; Mishina,
   Arina/0000-0003-1134-9366; S, Bakoev/0000-0002-0324-3580; Korobeinikova,
   Anna/0009-0003-0556-9343
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NR 73
TC 0
Z9 0
U1 0
U2 0
PU RUSSIAN ACAD SCI, INST CYTOLOGY GENETICS
PI NOVOSIBIRSK
PA PR LAVRENTYEVA 10, NOVOSIBIRSK, 630090, RUSSIA
SN 2500-0462
EI 2500-3259
J9 VAVILOVSKII ZH GENET
JI Vavilovskii Zhurnal Genet. Sel.
PY 2024
VL 28
IS 6
BP 640
EP 649
DI 10.18699/vjgb-24-71
PG 10
WC Agriculture, Multidisciplinary; Genetics & Heredity
WE Emerging Sources Citation Index (ESCI)
SC Agriculture; Genetics & Heredity
GA N0P1U
UT WOS:001361444000007
PM 39440312
OA gold
DA 2025-06-11
ER

PT J
AU Avetisyan, LG
   Simonyan, KV
   Danielyan, MH
   Sukiasyan, LM
   Chavushyan, VA
   Isoyan, AS
AF Avetisyan, L. G.
   Simonyan, K. V.
   Danielyan, M. H.
   Sukiasyan, L. M.
   Chavushyan, V. A.
   Isoyan, A. S.
TI High-Fructose Diet-Induced Neuronal Plasticity in Rats: Implications for
   Acetylcholinergic Pathology and Therapeutic Approaches
SO NEUROCHEMICAL JOURNAL
LA English
DT Article
DE cholinergic neurodegeneration; entorhinal cortex plasticity; Galantamine
ID BUTYRYLCHOLINESTERASE; SYSTEM
AB Galantamine, a centrally-acting acetylcholinesterase (AChE) inhibitor, is currently used as a first-line therapy for the symptomatic treatment of Alzheimer's disease. Long-term consumption of sugar-rich beverages has been shown to be associated with the development of various clinical conditions, including metabolic syndrome, impaired cholinergic transmission, and cognitive decline. The aim of this study was to determine the effect of long-term fructose consumption on changes in short-term plasticity (STP) parameters of rat brain lateral entorhinal cortex (lEC) neurons during high-frequency stimulation (HFS) of the cholinergic nucleus basalis magnocellularis (NBM) and to evaluate the therapeutic potential of Galantamine in neurodegeneration induced by diabetes. Using the method of determining AChE activity in brain slices from intact rats exposed to Galantamine, we revealed that AChE activity showed a declining trend in the NBM and lEC. Our findings indicated that STP changes were observed in the fructose group and were associated with degenerative disorders. Specifically, there was a dramatic decrease in the proportion and intensity of excitatory responses during HFS as well as a significant increase in the mean frequency of background spike activity in neuronal populations with all response types. Galantamine resulted in a recovery tendency for the balance and intensity of excitatory and inhibitory responses. A characteristic feature of the therapeutic effect of Galantamine is an increase in the share and expression of responses in the neuronal population, exhibiting tetanic depression and post-tetanic potentiation to NBM stimulation. This clearly indicates that these neurons play a key role in homeostatic plasticity and integration into neuronal chains of cholinergic projections.
C1 [Avetisyan, L. G.; Simonyan, K. V.; Danielyan, M. H.; Sukiasyan, L. M.; Chavushyan, V. A.; Isoyan, A. S.] Orbeli Inst Physiol NAS RA, Yerevan, Armenia.
   [Danielyan, M. H.; Sukiasyan, L. M.; Chavushyan, V. A.; Isoyan, A. S.] Yerevan State Med Univ M Heratsi, Yerevan, Armenia.
   [Chavushyan, V. A.] 22 Orbeli Bros St, Yerevan 0028, Armenia.
C3 National Academy of Sciences of Armenia; Institute of Physiology after
   L.A. Orbeli - NAS RA; Yerevan State Medical University
RP Chavushyan, VA (corresponding author), 22 Orbeli Bros St, Yerevan 0028, Armenia.
EM verginechavushyan@gmail.com
RI Simonyan, Karen/GXA-2514-2022; Avetisyan, Lyudmila/JTT-5747-2023;
   Danielyan, Margarita/ABF-3864-2021
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NR 23
TC 0
Z9 0
U1 0
U2 0
PU MAIK NAUKA/INTERPERIODICA/SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013-1578 USA
SN 1819-7124
EI 1819-7132
J9 NEUROCHEM J+
JI Neurochem. J.
PD DEC
PY 2023
VL 17
IS 4
BP 654
EP 661
DI 10.1134/S1819712423040062
PG 8
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA GO6B6
UT WOS:001153639400013
DA 2025-06-11
ER

PT J
AU Sternberg, Z
   Leung, C
   Sternberg, D
   Li, F
   Karmon, Y
   Chadha, K
   Levy, E
AF Sternberg, Zohara
   Leung, Christopher
   Sternberg, Daniel
   Li, Fan
   Karmon, Yuval
   Chadha, Kailash
   Levy, Elad
TI The Prevalence of the Classical and Non-Classical Cardiovascular Risk
   Factors in Multiple Sclerosis Patients
SO CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
LA English
DT Article
DE Blood pressure; dyslipidemia; homocysteine; inflammation; multiple
   sclerosis; plasma glucose
ID SYMPATHETIC-NERVOUS-SYSTEM; BLOOD-PRESSURE; INFLAMMATORY MARKERS;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; LIPID-METABOLISM; MECHANISMS;
   DEPRESSION; DISEASE; SUPPLEMENTATION
AB Background: Inflammation is known to play a role in cererovascular risk. Multiple sclerosis (MS) is a neurodegenerative disease that is initially characterized by inflammatory changes in the brain. We hypothesized that due to chronic inflammation, MS patients would present with a higher levels of cardiovascular (CV) risk factors than non-MS patients.
   Methods: We performed a retrospective chart review on 206 MS patients and 142 control patients suffering from meningiomas and acoustic neuromas, non inflammatory, non autoimmune diseases of the brain. The obtained data included fasting lipid profiles, plasma glucose, systolic and diastolic blood pressure (BP), serum levels of homocysteine and uric acid, data on iron status, smoking habit, and list of medications. In addition, data on indicators of MS disease severity was obtained for MS patients.
   Results: MS patients had significantly higher total plasma cholesterol, p = 0.01, and plasma high density lipoprotein, P < 0.001, but lower plasma glucose, P < 0.001, and systolic BP, P = 0.001, than non-MS patients. In addition, MS patients had lower erythrocyte sedimentation rate and serum vitamin B12, but higher serum folic acid and vitamin D3 than non-MS patients. A positive correlation was observed between plasma glucose and the extended disability status scale (EDSS), P = 0.008, and between plasma glucose and the rate of clinical relapse, P = 0.001.
   Conclusion: The MS pathophysiology may be among factors for the lower CV risk factors in MS patients. Future studies should examine whether the chronic use of many pharmacological agents influence CV risk factors in MS patients.
C1 [Sternberg, Zohara; Leung, Christopher; Sternberg, Daniel; Karmon, Yuval] Buffalo Med Ctr, Baird MS Ctr, Dept Neurol, Buffalo, NY 14203 USA.
   [Li, Fan] SUNY Buffalo, Dept Elect Engn, Buffalo, NY 14214 USA.
   [Chadha, Kailash] Roswell Pk Canc Inst, Dept Mol & Cellular Biol, Buffalo, NY 14263 USA.
   [Levy, Elad] Buffalo Med Ctr, Dept Neurosurg, Buffalo, NY 14203 USA.
C3 State University of New York (SUNY) System; University at Buffalo, SUNY;
   Roswell Park Comprehensive Cancer Center
RP Sternberg, Z (corresponding author), Buffalo Med Ctr, Buffalo, NY 14203 USA.
EM zs2@buffalo.edu
OI Sternberg, Zohara/0000-0002-2624-536X
FU Jog for the Jake, a local Buffalo philanthropic foundation
FX This study was conducted in part by support from the Jog for the Jake, a
   local Buffalo philanthropic foundation.
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NR 40
TC 36
Z9 37
U1 0
U2 11
PU BENTHAM SCIENCE PUBL
PI BUSUM
PA PO BOX 294, BUSUM, 1400 AG, NETHERLANDS
SN 1871-5273
EI 1996-3181
J9 CNS NEUROL DISORD-DR
JI CNS Neurol. Disord.-Drug Targets
PD FEB
PY 2013
VL 12
IS 1
BP 104
EP 111
DI 10.2174/1871527311312010016
PG 8
WC Neurosciences; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pharmacology & Pharmacy
GA 104MB
UT WOS:000315996300016
PM 23244431
DA 2025-06-11
ER

PT J
AU Rantanen, AT
   Kautiainen, H
   Ekblad, MO
   Korhonen, PE
AF Rantanen, Ansa Talvikki
   Kautiainen, Hannu
   Ekblad, Mikael Oskari
   Korhonen, Paivi Elina
TI Depressive symptoms and smoking: Effect on mortality in a primary care
   cohort
SO JOURNAL OF PSYCHOSOMATIC RESEARCH
LA English
DT Article
DE Depressive symptoms; Mortality; Primary care; Smoking
ID ALL-CAUSE MORTALITY; CARDIOVASCULAR-DISEASE; CIGARETTE-SMOKING;
   SEDENTARY BEHAVIOR; METABOLIC SYNDROME; 10-YEAR RISK; ASSOCIATION;
   METAANALYSIS; SCORE
AB Objective: Depressive symptoms have been suggested to increase mortality risk but causality remains unproven. Depressive symptoms increase likelihood of smoking which is thus a potential factor modifying the effect of depressive symptoms on mortality. This study aims to assess if the association of depressive symptoms and allcause mortality is affected by smoking. Methods: A prospective cohort study in Finnish primary care setting was conducted among 2557 middle-aged cardiovascular disease (CVD) risk persons identified in a population survey. Baseline depressive symptoms were assessed by Beck 's Depression Inventory (BDI) and current smoking by self -report. Data on mortality was obtained from the official statistics. Effect of depressive symptoms and smoking on all -cause mortality after 14year follow-up was estimated. Results: Compared to non -depressive non-smokers, the adjusted hazard ratio (HR) for all -cause mortality was 3.10 (95% CI 2.02 to 4.73) and 1.60 (95% CI 1.15 to 2.22) among smoking subjects with and without depressive symptoms, respectively. Compared to the general population, relative survival was higher among non -depressive non-smokers and lower among depressive smokers. Relative standardized mortality ratio (SMR) for all -cause mortality was 1.78 (95% CI 1.31 to 2.44) and 3.79 (95% CI 2.54 to 6.66) among non -depressive and depressive smokers, respectively, compared to non -depressive non-smokers. The HR for all -cause mortality and relative SMR of depressive non-smokers were not increased compared to non -depressive non-smokers. Conclusion: Current smoking and increased depressive symptoms seem to additively contribute to excess mortality.
C1 [Rantanen, Ansa Talvikki; Ekblad, Mikael Oskari; Korhonen, Paivi Elina] Univ Turku, Dept Gen Practice, Turku, Finland.
   [Rantanen, Ansa Talvikki; Ekblad, Mikael Oskari; Korhonen, Paivi Elina] Southwest Finland Wellbeing Serv Cty, Turku, Finland.
   [Kautiainen, Hannu] Kuopio Univ Hosp, Primary Hlth Care Unit, Kuopio, Finland.
   [Kautiainen, Hannu] Folkhalsan Res Ctr, Helsinki, Finland.
C3 University of Turku; Kuopio University Hospital; University of Eastern
   Finland; University of Eastern Finland Hospital; Folkhalsan Research
   Center
RP Rantanen, AT (corresponding author), Univ Turku, Dept Gen Practice, Turku, Finland.
EM atsipp@utu.fi; hannu.kautiainen@medcare.fi; moekbl@utu.fi; paikor@utu.fi
RI Rantanen, Ansa/HDM-6559-2022; Ekblad, Mikael/AAH-5010-2021
OI Rantanen, Ansa/0000-0001-5639-4756
FU State Provincial Office of Western Finland; Central Satakunta Health
   Federation of Municipalities; Finnish Cultural Foundation
FX This study was supported by the State Provincial Office of Western
   Finland, the Central Satakunta Health Federation of Municipalities, and
   the Finnish Cultural Foundation.
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NR 53
TC 0
Z9 0
U1 0
U2 2
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-3999
EI 1879-1360
J9 J PSYCHOSOM RES
JI J. Psychosomat. Res.
PD JUL
PY 2024
VL 182
AR 111690
DI 10.1016/j.jpsychores.2024.111690
EA MAY 2024
PG 7
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA TA2R5
UT WOS:001238475200001
PM 38704926
OA hybrid
DA 2025-06-11
ER

PT J
AU Liu, FH
   Liu, C
   Gong, TT
   Gao, S
   Sun, H
   Jiang, YT
   Zhang, JY
   Zhang, M
   Gao, C
   Li, XY
   Zhao, YH
   Wu, QJ
AF Liu, Fang-Hua
   Liu, Chuan
   Gong, Ting-Ting
   Gao, Song
   Sun, Hui
   Jiang, Yu-Ting
   Zhang, Jia-Yu
   Zhang, Meng
   Gao, Chang
   Li, Xin-Yu
   Zhao, Yu-Hong
   Wu, Qi-Jun
TI Dietary Inflammatory Index and Health Outcomes: An Umbrella Review of
   Systematic Review and Meta-Analyses of Observational Studies
SO FRONTIERS IN NUTRITION
LA English
DT Review
DE dietary inflammatory index; health outcomes; meta-analysis; umbrella
   review; observational studies
ID ENVIRONMENTAL RISK-FACTORS; METABOLIC SYNDROME; INSULIN-RESISTANCE;
   COLORECTAL-CANCER; ASSOCIATION; MORTALITY; DISEASE; MECHANISMS;
   OMEGA-3-FATTY-ACIDS; HETEROGENEITY
AB Background and Aims: The dietary inflammatory index (DII) is associated with non-communicable disease. We conducted an umbrella review to systematically evaluate meta-analyses of observational studies on DII and diverse health outcomes.
   Methods: We comprehensively searched the PubMed, Web of Science, and Embase databases to identify related systematic reviews and meta-analyses of observational studies. Those investigating the association between DII and a wide range of health outcomes in humans were eligible for inclusion. For each meta-analysis, we estimated the summary effect size by using fixed and random effects models, the 95% confidence interval, and the 95% prediction interval. We assessed heterogeneity, evidence of small-study effects, and excess significance bias.
   Results: The umbrella review identified 35 meta-analyses assessing associations between DII and various health outcomes: cancer (n = 24), mortality (n = 4), metabolic (n = 4), and other (n = 3). The methodological quality was high or moderate. Of the 35 meta-analyses, we observed highly suggestive evidence for harmful associations between digestive tract cancer, colorectal cancer, overall cancer, pharyngeal cancer, UADT cancer, and CVD mortality. Moreover, 11 harmful associations showed suggestive evidence: hormone-dependent cancer, rectal cancer, colon cancer, breast and prostate cancer, gynecological cancer, breast cancer, ovarian cancer, colorectal cancer, prostate cancer, all-cause mortality, and depression.
   Conclusion: DII is likely to be associated with harmful effects in multiple health outcomes. Robust randomized controlled trials are warranted to understand whether the observed results are causal.
   Systematic Review Registration: CRD42021218361
C1 [Liu, Fang-Hua; Sun, Hui; Jiang, Yu-Ting; Zhang, Jia-Yu; Zhang, Meng; Gao, Chang; Li, Xin-Yu; Zhao, Yu-Hong; Wu, Qi-Jun] China Med Univ, Dept Clin Epidemiol, Shengjing Hosp, Shenyang, Peoples R China.
   [Liu, Fang-Hua; Sun, Hui; Jiang, Yu-Ting; Zhang, Jia-Yu; Zhang, Meng; Gao, Chang; Li, Xin-Yu; Zhao, Yu-Hong; Wu, Qi-Jun] China Med Univ, Clin Res Ctr, Shengjing Hosp, Shenyang, Peoples R China.
   [Liu, Chuan; Gong, Ting-Ting; Gao, Song] China Med Univ, Dept Obstet & Gynecol, Shengjing Hosp, Shenyang, Peoples R China.
C3 China Medical University; China Medical University; China Medical
   University
RP Wu, QJ (corresponding author), China Med Univ, Dept Clin Epidemiol, Shengjing Hosp, Shenyang, Peoples R China.; Wu, QJ (corresponding author), China Med Univ, Clin Res Ctr, Shengjing Hosp, Shenyang, Peoples R China.; Gao, S (corresponding author), China Med Univ, Dept Obstet & Gynecol, Shengjing Hosp, Shenyang, Peoples R China.
EM gaos@sj-hospital.org; wuqj@sj-hospital.org
RI Li, Xinyu/AAP-3162-2021; 刘, 芳华/H-7907-2014; Jiang, Yuting/AAR-5384-2021
OI Wu, Qi-Jun/0000-0001-9421-5114
FU National Key R&D Program of China [2017YFC0907402]; Natural Science
   Foundation of China [82073647, 81602918]; LiaoNing Revitalization
   Talents Program [XLYC1907102]; Shenyang High Level Innovative Talents
   Support Program [RC190484]; 345 Talent Project of Shengjing Hospital of
   China Medical University
FX This work was supported by the National Key R&D Program of China (No.
   2017YFC0907402 to Y-HZ), the Natural Science Foundation of China (Nos.
   82073647 and 81602918 to Q-JW), LiaoNing Revitalization Talents Program
   (No. XLYC1907102 to Q-JW), Shenyang High Level Innovative Talents
   Support Program (No. RC190484 to Q-JW), and 345 Talent Project of
   Shengjing Hospital of China Medical University (Q-JW).
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NR 60
TC 24
Z9 24
U1 1
U2 22
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD MAY 19
PY 2021
VL 8
AR 647122
DI 10.3389/fnut.2021.647122
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA SL3TR
UT WOS:000656842300001
PM 34095187
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Ghosh, S
   Manchala, S
   Raghunath, M
   Sharma, G
   Singh, AK
   Sinha, JK
AF Ghosh, Shampa
   Manchala, Srividya
   Raghunath, Manchala
   Sharma, Gaurav
   Singh, Abhishek K.
   Sinha, Jitendra K.
TI Role of Phytomolecules in the Treatment of Obesity: Targets, Mechanisms
   and Limitations
SO CURRENT TOPICS IN MEDICINAL CHEMISTRY
LA English
DT Review
DE Adipocytokine; Lipid; Green tea; Hibiscus; Inflammatory; Polyphenol;
   Flavonoid
ID DOUBLE-BLIND; ANTIINFLAMMATORY ACTIVITY; AYURVEDIC MEDICINE;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; BODY-WEIGHT; GREEN TEA; EXTRACT;
   FOOD; RECEPTOR
AB Obesity has become a worldwide health problem. It triggers additional co-morbidities like cardiovascular diseases, cancer, depression, sleep disorders, gastrointestinal problems and many more. Excess accumulation of fat in obesity could be caused by many factors like sedentary lifestyle, consumption of high-fat diet, genetic predisposition, etc. Imbalanced energy metabolism i.e., greater energy consumption than utilisation, invariably underlies obesity. Considering the high prevalence and continuous, uncontrolled increase of this major public health issue, there is an urgent need to find appropriate therapeutic agents with minimal or no side effects. The high prevalence of obesity in recent years has led to a surge in the number of drugs available in the market that claim to control obesity. Although there is a long list of medicines and management strategies that are available, selecting the right therapeutic intervention and feasible management of obesity is a challenge. Several phytochemicals like hydroxycitric acid, flavonoids, tannins, anthocyanins, phytohaemagglutinin, thymoquinone and epigallocatechin gallate have been shown to possess promising anti-obesity properties. However, studies providing information on how various phytochemicals exert their anti-obesity effects are inadequate. This calls for more experimentation in this less explored area of research. Additionally, the complication of obesity arises when it is a result of multiple factors and associated with a number of co-morbidities. In order to handle such complexities, combinatorial therapeutic interventions become effective. In this review, we have described the medicinal chemistry of different highly effective phytochemicals which can be used in the effective treatment and management of obesity.
C1 [Ghosh, Shampa; Raghunath, Manchala] ICMR Natl Inst Nutr NIN, Hyderabad 500007, India.
   [Manchala, Srividya] PES Coll Pharm PESCP, BSK 1 Stage, Bengaluru 560050, India.
   [Sharma, Gaurav] TAFE NSW, Bldg J,Horsley Dr, Wetherill Pk, NSW 2164, Australia.
   [Singh, Abhishek K.; Sinha, Jitendra K.] Amity Univ UP, Amity Inst Neuropsychol & Amp Neurosci AINN, Sect 125, Noida 201303, India.
C3 Indian Council of Medical Research (ICMR); ICMR - National Institute of
   Nutrition (NIN); PES University; Amity University Noida
RP Singh, AK; Sinha, JK (corresponding author), Amity Univ UP, Amity Inst Neuropsychol & Amp Neurosci AINN, Sect 125, Noida 201303, India.
EM aksingh20@amity.edu; jitendrakumarsinha@gmail.com
RI Sharma, Gaurav/HKN-7322-2023; Ghosh, Shampa/G-4237-2012; Sinha, Jitendra
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OI Sinha, Jitendra Kumar/0000-0002-7444-6932
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U2 16
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1568-0266
EI 1873-5294
J9 CURR TOP MED CHEM
JI Curr. Top. Med. Chem.
PY 2021
VL 21
IS 10
BP 863
EP 877
DI 10.2174/1568026621666210305101804
PG 15
WC Chemistry, Medicinal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA UD5BF
UT WOS:000687220700003
PM 33676390
DA 2025-06-11
ER

PT J
AU Branyan, TE
   Sohrabji, F
AF Branyan, Taylor E.
   Sohrabji, Farida
TI Sex differences in stroke co-morbidities
SO EXPERIMENTAL NEUROLOGY
LA English
DT Review
DE Sex differences; Ischemic stroke; Hypertension; Atrial fibrillation;
   Metabolic disease; rT-PA; Thrombectomy; Nontraditional symptoms; Opioid
   addiction; Intimate partner violence
ID ACUTE ISCHEMIC-STROKE; BLOOD-PRESSURE CONTROL; ATRIAL-FIBRILLATION;
   GENDER-DIFFERENCES; RISK-FACTORS; SOCIOECONOMIC DIFFERENCES;
   PLASMINOGEN-ACTIVATOR; POSTSTROKE DEPRESSION; METABOLIC SYNDROME;
   CHOLESTEROL LEVELS
AB Males and females possess distinct biological differences that manifest in diverse risk profiles for acute and chronic diseases. A well-documented example of this is ischemic stroke. It has been demonstrated that older females have greater prevalence of, and worse outcome after, ischemic stroke than do males and younger females. Loss of estrogen after menopause is heavily implicated as a contributing factor for this phenomenon; however, there is mounting evidence to suggest that certain risk factors tend to occur more often in older females, such as hypertension and atrial fibrillation, while others more adversely affect females than they do males, such as diabetes and smoking. Sex-specific risk factors, such as oral contraceptive use and menopause, could also contribute to the discrepancy in stroke prevalence and outcome. Additionally, there is evidence to suggest that females tend to present with more nontraditional symptoms of acute stroke than do males, making it more difficult for clinicians to correctly identify the occurrence of a stroke, which may delay the administration of thrombolytic intervention. Finally, certain sociodemographic factors, such as the fact that females were more likely to live alone prior to stroke, may contribute to poorer recovery in females. This review will explore the various co-morbidities and sociodemographic factors that contribute to the greater prevalence of and poorer outcome after stroke in older females and will highlight the critical need for considering sex as a predisposing biological variable in stroke studies.
C1 [Branyan, Taylor E.; Sohrabji, Farida] Texas A&M HSC Coll Med, Dept Neurosci & Expt Therapeut, Womens Hlth Neurosci Program, Bryan, TX 77807 USA.
   [Branyan, Taylor E.; Sohrabji, Farida] Texas A&M Inst Neurosci, College Stn, TX 77840 USA.
C3 Texas A&M University System; Texas A&M University College Station; Texas
   A&M Health Science Center
RP Sohrabji, F (corresponding author), Texas A&M Hlth Sci Ctr, Dept Neurosci & Expt Therapeut, Coll Med, 8447 Riverside Pkwy, Bryan, TX 77807 USA.
EM f-sohrabji@tamu.edu
FU NIH [AG042189, NS074895]
FX This work was supported by NIH AG042189 and NS074895 to FS.
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NR 100
TC 41
Z9 44
U1 1
U2 16
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0014-4886
EI 1090-2430
J9 EXP NEUROL
JI Exp. Neurol.
PD OCT
PY 2020
VL 332
AR 113384
DI 10.1016/j.expneurol.2020.113384
PG 7
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA MV4MN
UT WOS:000556334300002
PM 32585156
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Pichlerova, D
   Bob, P
   Zmolikova, J
   Herlesova, J
   Ptacek, R
   Laker, MK
   Raboch, J
   Fait, T
   Weiss, P
AF Pichlerova, Dita
   Bob, Petr
   Zmolikova, Jana
   Herlesova, Jitka
   Ptacek, Radek
   Laker, Matthew K.
   Raboch, Jiri
   Fait, Tomas
   Weiss, Petr
TI Sexual Dysfunctions in Obese Women Before and After Bariatric Surgery
SO MEDICAL SCIENCE MONITOR
LA English
DT Article
DE Bariatric Medicine; Body Mass Index; Obesity, Abdominal; Sexual
   Dysfunctions, Psychological; Women's Health Services
ID QUALITY-OF-LIFE; BODY-MASS INDEX; ORAL-CONTRACEPTIVE FAILURE; ERECTILE
   DYSFUNCTION; METABOLIC SYNDROME; WEIGHT; HEALTH; ABUSE; ASSOCIATION;
   DEPRESSION
AB Background: Obesity and associated comorbidities increase the probability of sexual disorders. The present study evaluated sexual satisfaction levels in obese women prior to and following bariatric surgery, utilizing the validated Female Sexual Function Index (FSFI) to also evaluate the sexual satisfaction in obese and non-obese women.
   Material/Methods: 60 obese women (mean initial BMI of 43.7 +/- 5.9 kg/m(2); mean age of 41.7 +/- 10.8 years) were administered the questionnaire on sexual function (FSFI) preceding bariatric surgery (laparoscopic adjustable gastric banding, 22 women; gastric plication, 33 women; and biliopancreatic diversion, 5 women), 6 months and 12 months after the procedure, i.e., following substantial weight reduction (final mean BMI of 35.5 +/- 5.5 kg/m(2)). The control group comprised 60 non-obese women (mean BMI of 22.2 +/- 1.9 kg/m(2); mean age of 36.4 +/- 10.7 years).
   Results: Our findings indicate that baseline sexual function in the preoperative obese females was significantly lower than in non-obese women, with p<0.01 in each domain. Data gathered at the 6- and 12-month points following the procedure indicated no significant difference. Before the procedure, 31 obese subjects (51.6%) exceeded the cutoff for FSD, at the 6-month evaluation point, 17 women (39.5%) exceeded the cutoff, and at 12 months postoperatively, 18 subjects (41.9%) exceeded the cutoff, indicative of FSD. Among the non-obese controls, only 9 subjects (15%) exceeded the cutoff threshold.
   Conclusions: These findings show that substantive weight reduction resulting from bariatric surgery results in reduced sexual dysfunction in female subjects.
C1 [Pichlerova, Dita; Bob, Petr; Ptacek, Radek; Laker, Matthew K.; Raboch, Jiri] Charles Univ Prague, Fac Med 1, Dept Psychiat, Prague, Czech Republic.
   [Zmolikova, Jana] Na Homolce Hosp, Dept Clin Psychol, Prague, Czech Republic.
   [Herlesova, Jitka] OB Clin, Prague, Czech Republic.
   [Fait, Tomas] Charles Univ Prague, Med Fac 1, Gen Fac Hosp, Dept Gynecol & Obstet, Prague, Czech Republic.
   [Weiss, Petr] Charles Univ Prague, Fac Med 1, Inst Sexol, Prague, Czech Republic.
C3 General University Hospital Prague; Charles University Prague; Na
   Homolce Hospital; General University Hospital Prague; Charles University
   Prague; Charles University Prague
RP Bob, P (corresponding author), Charles Univ Prague, Fac Med 1, Dept Psychiat, Prague, Czech Republic.
EM petrbob@netscape.net
RI Žmolíková, Jana/K-4155-2017; Ptacek, Radek/C-6696-2009; Bob,
   Petr/E-3414-2012; Fait, Tomas/AAO-4609-2021
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NR 44
TC 12
Z9 12
U1 0
U2 8
PU INT SCIENTIFIC INFORMATION, INC
PI MELVILLE
PA 150 BROADHOLLOW RD, STE 114, MELVILLE, NY 11747 USA
EI 1643-3750
J9 MED SCI MONITOR
JI Med. Sci. Monitor
PD APR 27
PY 2019
VL 25
BP 3108
EP 3114
DI 10.12659/MSM.913614
PG 7
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Research & Experimental Medicine
GA HX1TC
UT WOS:000467175000002
PM 31028694
OA Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Lee, IT
   Wang, JS
   Lee, WJ
   Lin, SY
   Fu, CP
   Liang, KW
   Hsu, CY
   Sheu, WHH
AF Lee, I-Te
   Wang, Jun-Sing
   Lee, Wen-Jane
   Lin, Shih-Yi
   Fu, Chia-Po
   Liang, Kae-Woei
   Hsu, Chiann-Yi
   Sheu, Wayne Huey-Herng
TI The synergistic effect of vascular cell adhesion molecule-1 and coronary
   artery disease on brain-derived neurotrophic factor
SO CLINICA CHIMICA ACTA
LA English
DT Article
DE Brain-derived neurotrophic factor; Coronary artery disease; Vascular
   cell adhesion molecule-I; Oral glucose tolerance test
ID C-REACTIVE PROTEIN; METABOLIC SYNDROME; RISK-FACTORS;
   MYOCARDIAL-INFARCTION; ENDOTHELIAL-CELLS; P-SELECTIN; TNF-ALPHA;
   DEPRESSION; EXPRESSION; BDNF
AB Background: Brain-derived neurotrophic factor (BDNF) is important for neural protection and energy homeostasis. In this study, we examined the effects of vascular cell adhesion molecule-1 (VCAM-1) and coronary artery disease (CAD) on BDNF.
   Methods: Subjects who had undergone diagnostic angiography for angina were recruited, and a total of 240 subjects (144 with CAD and 96 without CAD) were enrolled. Serum BDNF was determined at 0, 30, and 120 min during an oral glucose tolerance test (OGTT) to calculate the area under the curve (AUC) for BDNF. Serum VCAM-1 was determined at fasting.
   Results: Significantly lower AUC of BDNF (42.8 +/- 10.7 vs. 47.4 +/- 11.7 ng-h/ml, P = 0.002) and higher serum VCAM-1 (583 +/- 383 vs.482 +/- 171 ng/ml, P = 0.017) were noted in subjects with CAD compared to those without CAD. High VCAM-1 level was an independent predictor of low AUC of BDNF in subjects with and without CAD (95%CI between -0.011 and -0.002, P = 0.008; -0.033 and -0.002, P = 0.029, respectively). Serum BDNF was lowest in the CAD subjects with high VCAM-1 levels at all time points during OGTT.
   Conclusion: Our results showed that CAD was associated with low serum BDNF in response to OGTT, and VCAM-1 had a synergistic effect with CAD on the BDNF. (C) 2017 Elsevier B.V. All rights reserved.
C1 [Lee, I-Te; Wang, Jun-Sing; Fu, Chia-Po; Sheu, Wayne Huey-Herng] Taichung Vet Gen Hosp, Div Endocrinol & Metab, Dept Internal Med, 1650 Taiwan Blvd,Sect 4, Taichung 40705, Taiwan.
   [Lee, I-Te] Chung Shan Med Univ, Sch Med, Taichung, Taiwan.
   [Lee, I-Te; Wang, Jun-Sing; Lin, Shih-Yi; Liang, Kae-Woei; Sheu, Wayne Huey-Herng] Natl Yang Ming Univ, Sch Med, Taipei, Taiwan.
   [Lee, Wen-Jane; Hsu, Chiann-Yi] Taichung Vet Gen Hosp, Dept Med Res, Taichung, Taiwan.
   [Lin, Shih-Yi] Taichung Vet Gen Hosp, Ctr Geriatr & Gerontol, Taichung, Taiwan.
   [Liang, Kae-Woei] Taichung Vet Gen Hosp, Ctr Cardiovasc, Taichung, Taiwan.
   [Sheu, Wayne Huey-Herng] Natl Chung Hsing Univ, Inst Med Technol, Taichung, Taiwan.
C3 Taichung Veterans General Hospital; Chung Shan Medical University;
   National Yang Ming Chiao Tung University; Taichung Veterans General
   Hospital; Taichung Veterans General Hospital; Taichung Veterans General
   Hospital; National Chung Hsing University
RP Sheu, WHH (corresponding author), Taichung Vet Gen Hosp, Div Endocrinol & Metab, Dept Internal Med, 1650 Taiwan Blvd,Sect 4, Taichung 40705, Taiwan.
EM whhsheu@vghtc.gov.tw
RI ; Wang, Jun-Sing/AFQ-4837-2022
OI Lee, I-Te/0000-0003-2665-3635; Wang, Jun-Sing/0000-0002-0887-6432
FU Taichung Veterans General Hospital, Taichung, Taiwan [TCVGH-1043504C,
   TCVGH1063502C, TCVGH-1063501E]; Ministry of Science and Technology,
   Taiwan [MOST 104-2314-B-075A-007, MOST 105-2314-B-075A003]
FX This work was supported by a grant from the Taichung Veterans General
   Hospital, Taichung, Taiwan (TCVGH-1043504C, TCVGH1063502C,
   TCVGH-1063501E) and the Ministry of Science and Technology, Taiwan (MOST
   104-2314-B-075A-007, MOST 105-2314-B-075A003). The statistical analysis
   was performed by the Biostatistics Task Force of Taichung Veterans
   General Hospital, Taichung, Taiwan.
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NR 58
TC 12
Z9 13
U1 0
U2 2
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0009-8981
EI 1873-3492
J9 CLIN CHIM ACTA
JI Clin. Chim. Acta
PD MAR
PY 2017
VL 466
BP 194
EP 200
DI 10.1016/j.cca.2017.01.026
PG 7
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA EQ1MQ
UT WOS:000397834600031
PM 28131673
DA 2025-06-11
ER

PT J
AU Linander, I
   Hammarström, A
   Johansson, K
AF Linander, Ida
   Hammarstrom, Anne
   Johansson, Klara
TI Which socio-economic measures are associated with psychological distress
   for men and women? A cohort analysis
SO EUROPEAN JOURNAL OF PUBLIC HEALTH
LA English
DT Article
ID METABOLIC SYNDROME; HEALTH; UNEMPLOYMENT; POSITION; DISORDERS; GENDER;
   POPULATION; DEPRESSION; DISADVANTAGE; INEQUALITIES
AB Background: There are contradictory results regarding whether there is a social gradient in common mental disorders or not, or if this relation differs for different indicators or by gender. We analysed the relation between various measures of socio-economic position and later psychological distress among men and women in a Swedish context. Methods: The study is based on data from the Northern Swedish Cohort (N= 1001, 93.5% response rate), a 27-year prospective study. Logistic regression was used to explore the relation between various indicators of socio-economic position at age 30 (occupation, education, financial strain, cash margin, unemployment and living primarily on social welfare or unemployment insurance) and psychological distress (age 42), controlling for earlier psychological distress (age 21) and parental occupational class. Register data were used to measure unemployment. All other variables were self-reported, and measured by a questionnaire. Results: Financial strain and living on social welfare or unemployment insurance at age 30 were associated with psychological distress at age 42 for men and women. Poor cash margin and unemployment were only associated with psychological distress in women, after controlling for potential confounders. Low occupational class and low education were not significantly related to later psychological distress. Conclusion: The two most commonly used measures of socio-economic position, occupation and education, were not significantly associated with psychological distress while other, less studied measures were. This study highlights the importance of measuring socio-economic position in several ways when studying common mental disorders, as well as to take gender into account.
C1 [Linander, Ida; Hammarstrom, Anne; Johansson, Klara] Umea Univ, Dept Publ Hlth & Clin Med, SE-90185 Umea, Sweden.
   [Linander, Ida] Umea Univ, Umea Ctr Gender Studies, SE-90185 Umea, Sweden.
C3 Umea University; Umea University
RP Linander, I (corresponding author), Umea Univ, Dept Publ Hlth & Clin Med, Family Med, SE-90185 Umea, Sweden.
EM ida.linander@umu.se
RI Hammarström, Anne/HNI-3080-2023; Linander, Ida/GSD-7007-2022
OI Johansson, Klara/0000-0002-3749-998X; Hammarstrom,
   Anne/0000-0002-4095-7961; Linander, Ida/0000-0001-6401-889X
FU FORMAS [259-2012-37]; County Council of Vasterbotten [322941]; Swedish
   Research Council [344-2011-5478]
FX The study was financed by grants from FORMAS, grant number 259-2012-37,
   the County Council of Vasterbotten, grant number 322941, and the Swedish
   Research Council, grant number 344-2011-5478.
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   Swedish Survey of Living Conditions, SWED SURV LIV COND
NR 39
TC 20
Z9 21
U1 1
U2 15
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1101-1262
EI 1464-360X
J9 EUR J PUBLIC HEALTH
JI Eur. J. Public Health
PD APR
PY 2015
VL 25
IS 2
BP 231
EP 236
DI 10.1093/eurpub/cku137
PG 7
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA CE9ZE
UT WOS:000352201500013
PM 25172836
OA Bronze
DA 2025-06-11
ER

PT J
AU Depp, CA
   Strassnig, M
   Mausbach, BT
   Bowie, CR
   Wolyniec, P
   Thornquist, MH
   Luke, JR
   McGrath, JA
   Pulver, AE
   Patterson, TL
   Harvey, PD
AF Depp, Colin A.
   Strassnig, Martin
   Mausbach, Brent T.
   Bowie, Christopher R.
   Wolyniec, Paula
   Thornquist, Mary H.
   Luke, James R.
   McGrath, John A.
   Pulver, Ann E.
   Patterson, Thomas L.
   Harvey, Philip D.
TI Association of obesity and treated hypertension and diabetes with
   cognitive ability in bipolar disorder and schizophrenia
SO BIPOLAR DISORDERS
LA English
DT Article
DE bipolar disorder; diabetes; health risk factors; hypertension;
   neuropsychology; obesity; psychosis
ID BODY-MASS INDEX; METABOLIC SYNDROME; MENTAL-DISORDERS; I DISORDER;
   PREVALENCE; TRIAL; INTERVENTION; DISABILITY; OVERWEIGHT; DEPRESSION
AB Objectives People with bipolar disorder or schizophrenia are at greater risk for obesity and other cardio-metabolic risk factors, and several prior studies have linked these risk factors to poorer cognitive ability. In a large ethnically homogenous outpatient sample, we examined associations among variables related to obesity, treated hypertension and/or diabetes and cognitive abilities in these two patient populations. Methods In a study cohort of outpatients with either bipolar disorder (n=341) or schizophrenia (n=417), we investigated the association of self-reported body mass index and current use of medications for hypertension or diabetes with performance on a comprehensive neurocognitive battery. We examined sociodemographic and clinical factors as potential covariates. Results Patients with bipolar disorder were less likely to be overweight or obese than patients with schizophrenia, and also less likely to be prescribed medication for hypertension or diabetes. However, obesity and treated hypertension were associated with worse global cognitive ability in bipolar disorder (as well as with poorer performance on individual tests of processing speed, reasoning/problem-solving, and sustained attention), with no such relationships observed in schizophrenia. Obesity was not associated with symptom severity in either group. Conclusions Although less prevalent in bipolar disorder compared to schizophrenia, obesity was associated with substantially worse cognitive performance in bipolar disorder. This association was independent of symptom severity and not present in schizophrenia. Better understanding of the mechanisms and management of obesity may aid in efforts to preserve cognitive health in bipolar disorder.
C1 [Depp, Colin A.; Mausbach, Brent T.; Patterson, Thomas L.] Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA.
   [Depp, Colin A.] VA San Diego Healthcare Syst, La Jolla, CA USA.
   [Strassnig, Martin; Harvey, Philip D.] Univ Miami, Miller Sch Med, Dept Psychiat & Behav Sci, Miami, FL 33136 USA.
   [Bowie, Christopher R.] Queens Univ, Dept Psychiat & Psychol, Kingston, ON, Canada.
   [Wolyniec, Paula; Thornquist, Mary H.; Luke, James R.; McGrath, John A.; Pulver, Ann E.] Johns Hopkins Univ, Dept Psychiat & Behav Sci, Baltimore, MD USA.
   [Harvey, Philip D.] Miami VA Med Ctr, Res Serv, Miami, FL USA.
C3 University of California System; University of California San Diego; US
   Department of Veterans Affairs; Veterans Health Administration (VHA); VA
   San Diego Healthcare System; University of Miami; Queens University -
   Canada; Johns Hopkins University
RP Depp, CA (corresponding author), Univ Calif San Diego, Dept Psychiat 0664, 9500 Gilman Dr, La Jolla, CA 92093 USA.
EM cdepp@ucsd.edu
RI depp, colin/D-1264-2009; Harvey, Philip/D-2455-2012
OI Mausbach, Brent/0000-0003-2884-8743; Harvey, Philip/0000-0002-9501-9366;
   McGrath, John A./0000-0002-9756-7892; Depp, Colin/0000-0002-1841-6229
FU NIMH [R34MH091260, R01MH100417, R01MH079784, RO1MH78775, R01MH078737]
FX This work was supported by NIMH grants R34MH091260, R01MH100417 (CAD),
   R01MH079784 (AEP), RO1MH78775 (PDH), and R01MH078737 (TLP).
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NR 39
TC 72
Z9 80
U1 0
U2 13
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1398-5647
EI 1399-5618
J9 BIPOLAR DISORD
JI Bipolar Disord.
PD JUN
PY 2014
VL 16
IS 4
BP 422
EP 431
DI 10.1111/bdi.12200
PG 10
WC Clinical Neurology; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Psychiatry
GA AJ2TX
UT WOS:000337517600008
PM 24725166
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Ohdo, S
   Koyanagi, S
   Matsunaga, N
AF Ohdo, Shigehiro
   Koyanagi, Satoru
   Matsunaga, Naoya
TI Chronopharmacological strategies: Intra- and inter-individual
   variability of molecular clock
SO ADVANCED DRUG DELIVERY REVIEWS
LA English
DT Review
DE Chronopharmacology; Clock gene; Intra-individual variability;
   Inter-individual variability; Gene delivery
ID MAMMALIAN CIRCADIAN CLOCK; SUPRACHIASMATIC NUCLEUS; CORTICOSTERONE
   RHYTHM; PERIPHERAL-TISSUES; TUMOR-SUPPRESSOR; DIURNAL RHYTHM;
   MESSENGER-RNA; GROWTH-FACTOR; CANCER-CELLS; MOUSE-LIVER
AB In all living organisms, one of the most indispensable biological functions is the circadian clock (suprachiasmatic nuclei; SCN), which acts like a multifunction timer to regulate homeostatic systems such as sleep and activity, hormone levels, appetite, and other bodily functions with 24 h cycles. Circadian rhythms regulate diverse physiologic processes, including homeostatic functions of steroid hormones and their receptors. Perturbations of these rhythms are associated with pathogenic conditions such as depression, diabetes and cancer. Clock genes are identified as the genes that ultimately control a vast array of circadian rhythms in physiology and behavior. Clock gene regulates several diseases such as cancer, metabolic syndrome and sleep etc. CLOCK mutation affects the expression of rhythmic genes in wild-type (WT) tissue, but also affects that of non-rhythmic genes. On the other hand, the change of the drug pharmacodynamic and pharmacokinetic (PK/PD) parameters are influenced by not only inter-individual variability but also intra-individual variabilities of medications. Identification of a rhythmic marker for selecting dosing time will lead to improved progress and diffusion of chronopharmacotherapy. The mechanisms underlying chronopharmacological findings should be clarified from viewpoint of clock genes. On the other hand, several drugs have an effect on molecular clock. Thus, the knowledge of intra- and inter-individual variability of molecular clock should be applied for the clinical practice. Therefore, we introduce the regulatory system of biological rhythm from viewpoints of clock genes and the possibility of pharmacotherapy based on the intra- and inter-individual variability of clock genes. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Ohdo, Shigehiro; Koyanagi, Satoru; Matsunaga, Naoya] Kyushu Univ, Grad Sch Pharmaceut Sci, Dept Pharmaceut, Higashi Ku, Fukuoka 8128582, Japan.
C3 Kyushu University
RP Ohdo, S (corresponding author), Kyushu Univ, Grad Sch Pharmaceut Sci, Dept Pharmaceut, Higashi Ku, 3-1-1 Maidashi, Fukuoka 8128582, Japan.
EM ohdo@phar.kyushu-u.ac.jp
RI Koyanagi, Satoru/AAE-6843-2020
OI matsunaga2, naoya2/0000-0001-6226-8473; Koyanagi,
   Satoru/0000-0003-4849-2377
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NR 108
TC 35
Z9 42
U1 0
U2 14
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0169-409X
EI 1872-8294
J9 ADV DRUG DELIVER REV
JI Adv. Drug Deliv. Rev.
PD JUL 31
PY 2010
VL 62
IS 9-10
BP 885
EP 897
DI 10.1016/j.addr.2010.04.005
PG 13
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 645XH
UT WOS:000281499000004
PM 20638941
DA 2025-06-11
ER

PT J
AU Sato, Y
   Yasui-Furukori, N
   Nakagami, T
   Saito, M
   Kaneko, S
AF Sato, Yasushi
   Yasui-Furukori, Norio
   Nakagami, Taku
   Saito, Manabu
   Kaneko, Sunao
TI Augmentation of antidepressants with perospirone for treatment-resistant
   major depressive disorder
SO PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
LA English
DT Review
DE Augmentation; Depression; Perospirone
ID ATYPICAL ANTIPSYCHOTICS; METABOLIC SYNDROME; BINDING PROFILE;
   ZIPRASIDONE; RECEPTOR; SCHIZOPHRENIA; RISPERIDONE; PREVALENCE; EFFICACY;
   FAILURE
AB We examined the efficacy and tolerability of perospirone, a dopamine D2 and 5-HT2A receptor antagonist and a partial 5-HT1A receptor agonist, in the augmentation of antidepressant treatment of partially responding and nonresponding patients with major depressive disorder. Twelve patients with major depressive disorder and an incomplete or no response to different kinds of antidepressants (selective serotonin reuptake inhibitor, milnacipran, or sulpride) monotherapy or polytherapy for 8 weeks or more were treated with perospirone augmentation in an eight-week, open-label study. Data were gathered from July 2006 to March 2008. The mean duration of antidepressant pharmacotherapy at baseline was 28 weeks. At baseline, the mean (+/- SD) of the MADRS scores was 35.8 +/- 10.1. The mean (+/- SD) initial dose of perospirone was 7.0 +/- 2.9 mg/day and the final dose was 11.7 +/- 6.6 mg/day. Significant reductions in MADRS scores were observed at weeks 2, 4, 6 and 8. Although two of the twelve subjects who completed the protocol achieved remission by the study endpoint, five of the twelve patients were responders (i.e., >50% improvement in the MADRS score). Sleepiness and tremor were observed in six patients and one patient, respectively, resulting in a reduction of perospirone dose due to these side effects. The discontinuation rate after 8 weeks of treatment was zero. These findings suggest that perospirone may be an effective augmentation strategy for improving therapeutic response in patients with treatment-resistant major depressive disorder when administered in combination with standard antidepressant therapy. Based on this clinical evidence, a double-blind, placebo-controlled trial is warranted. (C) 2008 Elsevier Inc. All rights reserved.
C1 [Sato, Yasushi; Yasui-Furukori, Norio; Nakagami, Taku; Saito, Manabu; Kaneko, Sunao] Hirosaki Grad Univ, Dept Neuropsychiat, Sch Med, Hirosaki, Aomori, Japan.
RP Yasui-Furukori, N (corresponding author), Hirosaki Univ, Dept Neuropsychiat, Sch Med, Hirosaki, Aomori 0368562, Japan.
EM yasufuru@cc.hirosaki-u.ac.jp
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NR 20
TC 7
Z9 7
U1 0
U2 2
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0278-5846
EI 1878-4216
J9 PROG NEURO-PSYCHOPH
JI Prog. Neuro-Psychopharmacol. Biol. Psychiatry
PD APR 30
PY 2009
VL 33
IS 3
BP 416
EP 418
DI 10.1016/j.pnpbp.2008.12.018
PG 3
WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA 437EY
UT WOS:000265470500005
PM 19166896
DA 2025-06-11
ER

PT J
AU Charitakis, E
   Dragioti, E
   Stratinaki, M
   Korela, D
   Tzeis, S
   Almroth, H
   Liuba, I
   Jönsson, AH
   Charalambous, G
   Karlsson, LO
   Tsartsalis, D
AF Charitakis, Emmanouil
   Dragioti, Elena
   Stratinaki, Maria
   Korela, Dafni
   Tzeis, Stylianos
   Almroth, Henrik
   Liuba, Ioan
   Jonsson, Anders Hassel
   Charalambous, Georgios
   Karlsson, Lars O.
   Tsartsalis, Dimitrios
TI Predictors of recurrence after catheter ablation and electrical
   cardioversion of atrial fibrillation: an umbrella review of
   meta-analyses
SO EUROPACE
LA English
DT Review
DE Catheter ablation; Atrial fibrillation; Umbrella review; Electrical
   cardioversion
ID DEPRESSION; OUTCOMES; FLUTTER; IMPACT
AB Aims The recurrence rates after catheter ablation (CA) and direct current (DC) cardioversion remain high, although they have been established treatments of rhythm control of atrial fibrillation (AF). This umbrella review systematically appraises published meta-analyses of both observational and randomized controlled trials (RCTs) for the association of risk and protective factors for arrhythmia recurrence after CA and DC cardioversion of AF. Methods and results Three bibliographic databases were searched up to June 2021. Evidence of association was rated as convincing, highly suggestive, suggestive, weak, or not significant with respect to observational studies and as high, moderate, low, or very low with respect to RCTs, according to established criteria. Thirty-one meta-analyses were included. Of the 28 associations between CA and the risk of arrhythmia recurrence, none presented convincing evidence, and only the time from diagnosis to ablation over 1 year provided highly suggestive evidence. The association between hypertension and metabolic profile provided suggestive evidence. The associations of Class IC and III antiarrhythmic drugs use with the recurrence after DC cardioversion were supported by an intermediate level of evidence. Conclusion Although AF is a major health issue, few risk- and protective factors for AF recurrence have been identified. None of these factors examined were supported by convincing evidence, whereas established factors such as female gender and left atrial volume showed only weak association. An early CA strategy combined with treatment of metabolic syndrome and hypertension prior to CA may reduce the risk of arrhythmia recurrence. The use of antiarrhythmics can increase the success rate of DC cardioversion. Systematic review registration PROSPERO registry number: CRD42021270613.
C1 [Charitakis, Emmanouil; Almroth, Henrik; Liuba, Ioan; Jonsson, Anders Hassel; Karlsson, Lars O.] Linkoping Univ, Dept Cardiol, S-58185 Linkoping, Sweden.
   [Charitakis, Emmanouil; Dragioti, Elena; Almroth, Henrik; Liuba, Ioan; Jonsson, Anders Hassel; Karlsson, Lars O.] Linkoping Univ, Dept Hlth Med & Caring Sci, S-58185 Linkoping, Sweden.
   [Dragioti, Elena] Linkoping Univ, Pain & Rehabil Ctr, S-58185 Linkoping, Sweden.
   [Stratinaki, Maria; Korela, Dafni] Venizeleio Gen Hosp, Dept Cardiol, Iraklion 71409, Crete, Greece.
   [Tzeis, Stylianos] Mitera Hosp Hygeia Grp, Athens 15123, Greece.
   [Charalambous, Georgios; Tsartsalis, Dimitrios] Hippokrateion Hosp, Dept Emergency Med, Vasilissis Sofias 114, Athens 11527, Greece.
C3 Linkoping University; Linkoping University; Linkoping University;
   Hippokration General Hospital
RP Tsartsalis, D (corresponding author), Hippokrateion Hosp, Dept Emergency Med, Vasilissis Sofias 114, Athens 11527, Greece.
EM dtsartsalis@gmail.com
RI Charitakis, Emmanouil/JDD-7126-2023; Tsartsalis,
   Dimitrios/JMQ-4274-2023; CHARALAMPOUS, GEORGE/KIB-6816-2024
OI Charalambous, Georgios/0000-0001-6384-732X; Korela,
   Dafni/0000-0003-0774-4339; Charitakis, Emmanouil/0000-0002-2514-5324;
   Liuba, Ioan/0000-0001-7370-6993; Tsartsalis,
   Dimitrios/0000-0002-7535-938X; Dragioti, Elena/0000-0001-9019-4125;
   Stratinaki, Maria/0000-0001-8720-1830
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NR 43
TC 15
Z9 15
U1 0
U2 6
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1099-5129
EI 1532-2092
J9 EUROPACE
JI Europace
PD FEB 8
PY 2023
VL 25
IS 1
BP 40
EP 48
DI 10.1093/europace/euac143
EA AUG 2022
PG 9
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA X4LJ6
UT WOS:000846934400001
PM 36037026
OA Green Published
DA 2025-06-11
ER

PT J
AU Wang, Y
   Ma, T
   Zhu, YS
   Chu, XF
   Yao, S
   Wang, HF
   Cai, J
   Wang, XF
   Jiang, XY
AF Wang, Yong
   Ma, Teng
   Zhu, Yin-Sheng
   Chu, Xue-Feng
   Yao, Shun
   Wang, Hong-Fei
   Cai, Jian
   Wang, Xiao-Feng
   Jiang, Xiao-Yan
TI The KSR2-rs7973260 Polymorphism is Associated with Metabolic
   Phenotypes, but Not Psychological Phenotypes, in Chinese Elders
SO GENETIC TESTING AND MOLECULAR BIOMARKERS
LA English
DT Article
DE KSR2; pleiotropic effects; subjective well-being; depressive symptoms;
   metabolic phenotypes
ID GENOME-WIDE ASSOCIATION; GENETICS; SATISFACTION; DEPRESSION; MUTATIONS;
   LONGEVITY; HAPPINESS; VARIANTS; QUALITY; HEALTH
AB Objective: To examine the associations between genetic variants of KSR2 (kinase suppressor of RAS)-rs7973260, RAPGEF6 (guanine nucleotide exchange factor 6)-rs3756290, LOC105377703-rs4481363, and subjective wellbeing (SWB) and depressive symptoms (DSs) in Chinese elders, which were recently associated in a genome-wide association study conducted in Caucasians. The pleiotropic effects of KSR2-rs7973260 on metabolic phenotypes were also explored.
   Materials and Methods: We used data from 1788 older individuals aged 70-84 years from the aging arm of the Rugao Longevity and Aging Study, a population-based cohort study conducted in the Jiangsu province of China.
   Results: No significant distributions of genotype frequencies were observed between life-satisfied and -unsatisfied groups across those with the three polymorphisms. The level of SWB components (positive affect, negative affect, and affect balance) and DSs did not differ among genotypes of the three variants. However, the presence of GA+AA of KSR2-rs7973260 was significantly higher in the metabolic syndrome (MetS), severe hypertriglyceridemia (HTG), and diabetes groups than in control groups (43.7% vs. 37.6%, 46.4% vs. 37.6%, 45.8% vs. 37.9%, respectively). The A allele of rs7973260 was associated with increased risk of MetS, severe HTG, and diabetes with an odds ratios (95% confidence intervals) of 1.289 (1.002-1.658), 1.438 (1.076-1.921), and 1.384 (1.022-1.875), which remained significant after multiple adjustments.
   Conclusion: Rs7973260, rs3756290, and rs4481363 were not associated with SWB and DSs in Chinese elders. However, the KSR2-rs7973260A allele exhibited pleiotropic effects on some metabolic phenotypes in Chinese elders. These effects should be validated in future studies.
C1 [Wang, Yong; Zhu, Yin-Sheng; Chu, Xue-Feng] Rugao Peoples Hosp, Rugao, Peoples R China.
   [Ma, Teng; Yao, Shun; Wang, Xiao-Feng] Fudan Univ, Inst Biomed Sci, Sch Life Sci,MOE Key Lab Contemporary Anthropol, State Key Lab Genet Engn,Unit Epidemiol, Shanghai 200433, Peoples R China.
   [Wang, Hong-Fei] Second Mil Med Univ, Changhai Hosp, Dept Vasc Surg, Shanghai, Peoples R China.
   [Cai, Jian] Xinjiang Med Univ, Affiliated Hosp 1, Dept Neurol, Urumqi, Peoples R China.
   [Jiang, Xiao-Yan] Tongji Univ, Sch Med, Key Lab Arrhythmias, Minist Educ China, Shanghai 200092, Peoples R China.
   Tongji Univ, Sch Med, Dept Pathol & Pathophysiol, Shanghai, Peoples R China.
   [Jiang, Xiao-Yan] Tongji Univ, Inst Med Genet, Shanghai, Peoples R China.
C3 Fudan University; Naval Medical University; Xinjiang Medical University;
   Tongji University; Ministry of Education - China; Tongji University;
   Tongji University
RP Wang, XF (corresponding author), Fudan Univ, Inst Biomed Sci, Sch Life Sci,MOE Key Lab Contemporary Anthropol, State Key Lab Genet Engn,Unit Epidemiol, Shanghai 200433, Peoples R China.; Jiang, XY (corresponding author), Tongji Univ, Sch Med, Key Lab Arrhythmias, Minist Educ China, Shanghai 200092, Peoples R China.
EM xiaofengwang71@163.com; xiaoyanjiang001@163.com
RI xiaofeng, wang/GYQ-6412-2022; Wang, Hongfei/JCF-2357-2023
OI yao, Shun/0000-0002-4702-6748
FU National Natural Science Foundation [81670465, 81571372, 81260180];
   Shanghai Municipal Natural Science Foundation [16ZR1439600];
   International Cooperation Project of Ministry of Science and Technology
   [2014DFA32830]
FX We acknowledge all participants involved in the study. This work was
   supported by grants from the National Natural Science Foundation
   (81670465, 81571372, and 81260180), the Shanghai Municipal Natural
   Science Foundation (16ZR1439600), and the International Cooperation
   Project of Ministry of Science and Technology (2014DFA32830).
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NR 33
TC 5
Z9 5
U1 0
U2 16
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1945-0265
EI 1945-0257
J9 GENET TEST MOL BIOMA
JI Genet. Test. Mol. Biomark.
PD JUL
PY 2017
VL 21
IS 7
BP 416
EP 421
DI 10.1089/gtmb.2016.0402
PG 6
WC Biochemistry & Molecular Biology; Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Biochemistry & Molecular Biology; Genetics & Heredity
GA FA7YJ
UT WOS:000405663000003
PM 28537769
DA 2025-06-11
ER

PT J
AU Campanale, A
   Inserra, A
   Comai, S
AF Campanale, Antonella
   Inserra, Antonio
   Comai, Stefano
TI Therapeutic modulation of the kynurenine pathway in severe mental
   illness and comorbidities: A potential role for serotonergic
   psychedelics
SO PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
LA English
DT Article
DE Kynurenine pathway; Gut-brain axis; Severe mental illness; Serotonergic
   psychedelics
ID LYSERGIC-ACID DIETHYLAMIDE; MAJOR DEPRESSIVE DISORDER; ARYL-HYDROCARBON
   RECEPTOR; IRRITABLE-BOWEL-SYNDROME; INDOLEAMINE 2,3 DIOXYGENASE;
   MEDICATION-FREE PATIENTS; LIFE-THREATENING CANCER; T-CELL APOPTOSIS;
   GUT-BRAIN AXIS; DOUBLE-BLIND
AB Mounting evidence points towards a crucial role of the kynurenine pathway (KP) in the altered gut-brain axis (GBA) balance in severe mental illness (SMI, namely depression, bipolar disorder, and schizophrenia) and cardiometabolic comorbidities. Preliminary evidence shows that serotonergic psychedelics and their analogues may hold therapeutic potential in addressing the altered KP in the dysregulated GBA in SMI and comorbidities. In fact, aside from their effects on mood, psychedelics elicit therapeutic improvement in preclinical models of obesity, metabolic syndrome, and vascular inflammation, which are highly comorbid with SMI. Here, we review the literature on the therapeutic modulation of the KP in the dysregulated GBA in SMI and comorbidities, and the potential application of psychedelics to address the altered KP in the brain and systemic dysfunction underlying SMI and comorbidities. Psychedelics might therapeutically modulate the KP in the altered GBA in SMI and comorbidities either directly, via altering the metabolic pathway by influencing the ratelimiting enzymes of the KP and affecting the levels of available tryptophan, or indirectly, by affecting the gut microbiome, gut metabolome, metabolism, and the immune system. Despite promising preliminary evidence, the mechanisms and outcomes of the KP modulation with psychedelics in SMI and systemic comorbidities remain largely unknown and require further investigation. Several concerns are discussed surrounding the potential side effects of this approach in specific cohorts of individuals with SMI and systemic comorbidities.
C1 [Campanale, Antonella; Inserra, Antonio; Comai, Stefano] McGill Univ, Dept Psychiat, Montreal, PQ, Canada.
   [Comai, Stefano] Univ Padua, Dept Pharmaceut & Pharmacol Sci, Padua, PD, Italy.
   [Comai, Stefano] IRCCS San Raffaele Sci Inst, Milan, Italy.
   [Comai, Stefano] Univ Padua, Dept Biomed Sci, Padua, Italy.
C3 McGill University; University of Padua; Vita-Salute San Raffaele
   University; IRCCS Ospedale San Raffaele; University of Padua
RP Comai, S (corresponding author), Univ Padua, Dept Pharmaceut & Pharmacol Sci, Translat Neuropsychopharmacol Lab, Largo Meneghetti 2, I-35131 Padua, Italy.
EM stefano.comai@unipd.it
RI Comai, Stefano/J-6397-2016; Inserra, Antonio/AFQ-4500-2022
OI Campanale, Antonella/0009-0006-8112-3978; Inserra,
   Antonio/0000-0002-7261-5659
FU RI-MUHC Doctoral scholarship and Excellence Graduate Awards; CIHR; FRQS;
   QART
FX Antonella Campanale is the recipient of a RI-MUHC Doctoral scholarship
   and Excellence Graduate Awards. Antonio Inserra is the recipient of a
   CIHR, FRQS and QART postdoctoral fellowship.
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NR 418
TC 8
Z9 8
U1 1
U2 5
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0278-5846
EI 1878-4216
J9 PROG NEURO-PSYCHOPH
JI Prog. Neuro-Psychopharmacol. Biol. Psychiatry
PD AUG 30
PY 2024
VL 134
AR 111058
DI 10.1016/j.pnpbp.2024.111058
EA JUN 2024
PG 19
WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA XB5R2
UT WOS:001259241400001
PM 38885875
OA hybrid
DA 2025-06-11
ER

PT J
AU Hardy, DS
   Garvin, JT
   Mersha, TB
AF Hardy, Dale S.
   Garvin, Jane T.
   Mersha, Tesfaye B.
TI Ancestry Specific Polygenic Risk Score, Dietary Patterns, Physical
   Activity, and Cardiovascular Disease
SO NUTRIENTS
LA English
DT Article
DE polygenic risk score; dietary patterns; DASH diet; Mediterranean diet;
   southern diet; physical activity; interaction; cardiovascular disease;
   race; ancestry
ID METABOLIC SYNDROME; DESIGN; ATHEROSCLEROSIS; ASSOCIATIONS
AB It is unknown whether the impact of high diet quality and physical activity depends on the level of polygenic risk score (PRS) in different ancestries. Our cross-sectional study utilized de-identified data from 1987-2010 for self-reported European Americans (n = 6575) and African Americans (n = 1606). The high-risk PRS increased ASCVD risk by 59% (Risk Ratio (RR) = 1.59; 95% Confidence Interval:1.16-2.17) in the highest tertile for African Americans and by 15% (RR = 1.15; 1.13-1.30) and 18% (RR = 1.18; 1.04-1.35) in the second and highest tertiles compared to the lowest tertile in European Americans. Within the highest PRS tertiles, high physical activity-diet combinations (Dietary Approaches to Stop High Blood Pressure (DASH), Mediterranean, or Southern) reduced ASCVD risks by 9% (RR = 0.91; 0.85-0.96) to 15% (RR = 0.85; 0.80-0.90) in European Americans; and by 13% (RR = 0.87; 0.78-0.97) and 18% (RR = 0.82; 0.72-0.95) for DASH and Mediterranean diets, respectively, in African Americans. Top molecular pathways included fructose metabolism and catabolism linked to obesity, insulin resistance, and type 2 diabetes. Additional molecular pathways for African Americans were Vitamin D linked to depression and aging acceleration and death signaling associated with cancer. Effects of high diet quality and high physical activity can counterbalance the influences of genetically high-risk PRSs on ASCVD risk, especially in African Americans.
C1 [Hardy, Dale S.] Morehouse Sch Med, Dept Internal Med, Atlanta, GA 30310 USA.
   [Garvin, Jane T.] Walden Univ, Coll Nursing, Minneapolis, MN 55401 USA.
   [Mersha, Tesfaye B.] Univ Cincinnati, Coll Med, Cincinnati Childrens Hosp Med Ctr, Cincinnati, OH 45229 USA.
C3 Morehouse School of Medicine; Walden University; Cincinnati Children's
   Hospital Medical Center; University System of Ohio; University of
   Cincinnati
RP Hardy, DS (corresponding author), Morehouse Sch Med, Dept Internal Med, Atlanta, GA 30310 USA.
EM dhardy@msm.edu; jane.garvin@mail.waldenu.edu; tesfaye.mersha@cchmc.org
OI Hardy, Dale/0000-0001-8778-5661; Garvin, Jane/0000-0001-6023-3269;
   Mersha, Tesfaye/0000-0002-9189-8447
FU National Heart, Lung, and Blood Institute (NHLBI)
FX The authors would like to thank Bamidele Tayo for his guidance in
   preparing datasets for genotyping imputation and analysis of the imputed
   datasets for PRS preparation.
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NR 51
TC 0
Z9 0
U1 1
U2 4
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD FEB
PY 2024
VL 16
IS 4
AR 567
DI 10.3390/nu16040567
PG 18
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA JI8L7
UT WOS:001172627000001
PM 38398891
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Inamura, K
   Shinagawa, S
   Nagata, T
   Tagai, K
   Nukariya, K
   Shigeta, M
AF Inamura, Keisuke
   Shinagawa, Shunichiro
   Nagata, Tomoyuki
   Tagai, Kenji
   Nukariya, Kazutaka
   Shigeta, Masahiro
TI Education level is associated with neuropsychiatric symptoms in patients
   with amnestic-mild cognitive impairment
SO PSYCHOGERIATRICS
LA English
DT Article
DE cognitive reserve; dementia; education; MCI; neuropsychiatric symptoms
ID ALZHEIMERS-DISEASE; RISK-FACTORS; METABOLIC SYNDROME; CAREGIVER BURDEN;
   DEMENTIA; PREVALENCE; DEPRESSION; COMMUNITY; MANIFESTATIONS; PROGRESSION
AB Background We examined differences in the severity of neuropsychiatric symptom (NPS) subsyndromes according to education level among patients with amnestic-mild cognitive impairment (a-MCI) with the aim of identifying patient demographics related to NPS subsyndromes. Methods Overall, 140 patients with a-MCI were included. We divided the patients into three groups according to their educational level (primary education, middle education, and high education) and compared their demographics. To explore the severity of NPS subsyndromes according to educational level, we used the Neuropsychiatric Inventory (NPI) after adjustments for the Mini-Mental State Examination (MMSE) score. Finally, NPS subsyndromes that were identified as being related to educational level were further explored using a general linear model (GLM). Results Significant differences in several demographics were observed among the three groups. Among the NPS subsyndromes, the scores for aggressiveness were significantly higher in the primary and high education groups than in the middle education group, while the apathy/eating problem scores were significantly higher in the primary education group than in the other groups. The GLM analyses showed that aggressiveness was related to marital status and the Zarit Caregiver Burden Interview (ZBI-J) score, while apathy/eating problems were related to the instrumental activities of daily living (IADL) percentage, the ZBI-J score, and the education level in years. Conclusions Among NPS subsyndromes, aggressiveness and apathy/eating problems differed according to education level in patients with a-MCI. A GLM analysis suggested that not only education level, but also various other factors should be considered when determining the need for NPS interventions.
C1 [Inamura, Keisuke; Shinagawa, Shunichiro; Nagata, Tomoyuki; Tagai, Kenji; Shigeta, Masahiro] Jikei Univ, Sch Med, Dept Psychiat, Chiba, Japan.
   [Nukariya, Kazutaka] Jikei Univ, Sch Med, Kashiwa Hosp, Dept Psychiat, Chiba, Japan.
C3 Jikei University; Jikei University
RP Inamura, K (corresponding author), Jikei Univ, Sch Med, Dept Psychiat, Minato Ku, 3-19-18 Nishi Shimbashi, Tokyo 1058471, Japan.
EM inamura@jikei.ac.jp
OI Nagata, Tomoyuki/0000-0002-8731-9887
FU JSPS KAKENHI [21K15735]; Grants-in-Aid for Scientific Research
   [21K15735] Funding Source: KAKEN
FX This work was supported by JSPS KAKENHI Grant Number 21K15735.
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NR 66
TC 4
Z9 5
U1 0
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1346-3500
EI 1479-8301
J9 PSYCHOGERIATRICS
JI Psychogeriatrics
PD MAY
PY 2022
VL 22
IS 3
BP 343
EP 352
DI 10.1111/psyg.12818
EA FEB 2022
PG 10
WC Geriatrics & Gerontology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology; Psychiatry
GA 0U9UT
UT WOS:000757685000001
PM 35181960
DA 2025-06-11
ER

PT J
AU Özsoy, F
   Zorlu, C
   Kaya, S
AF Ozsoy, Filiz
   Zorlu, Cagri
   Kaya, Suheda
TI Electrocardiographic Evaluation of the Ventricular Arrhythmia Risk in
   Patients Diagnosed With Schizophrenia
SO ALPHA PSYCHIATRY
LA English
DT Article
DE Schizophrenia; electrocardiography; QT-interval
ID P-WAVE DISPERSION; NEGATIVE SYNDROME SCALE; QT INTERVAL; METABOLIC
   SYNDROME; MORTALITY; POPULATIONS; RELIABILITY; INPATIENTS; VALIDITY;
   PEAK
AB Objective: The purpose of this study was to examine electrocardiographic ventricular arrhythmia predictors in patients with schizophrenia by comparing with healthy controls.
   Methods: The study included 100 patients with schizophrenia and 100 healthy controls. Electrocardiography (ECG) was performed on all participants in resting position. T-wave peak to end (Tp-e), QT ranges, P-wave dispersion (Pd), and R-R range were measured. Then, the Schizophrenia Positive and Negative Syndrome Scale (PANSS) and the Calgary Depression Scale for Schizophrenia (CDSS) were applied to the schizophrenia group.
   Results: The PANSS positive symptom subscale was calculated as 10.41 (SD = 2.27), the negative symptom subscale was calculated as 14.44 (SD = 5.42), and the overall functionality level was calculated as 27.04 (SD = 5.43). The mean CDSS score was determined to be 3.74 (SD = 2.15). No differences were detected in the heart rate measurements of the patient and control groups in ECG results (P = .427). The minimum QT interval and minimum Tp-e wave times were found to be low in the patient group (P < .001 for both intervals). Corrected QTc dispersion, Pd, Tp-e dispersion, and QT dispersion were found to be higher in the patient group than in healthy controls (P < .001 for all intervals).
   Discussion: Based on our results, it is possible to speculate that patients with schizophrenia are at a risk of developing cardiac arrhythmia and cardiac dysfunction if they do not receive treatment. For this reason, clinicians should pay attention to cardiac transmission problems when organizing the treatment of patients. Further studies should be conducted to determine cardiac problems in patients with schizophrenia.
C1 [Ozsoy, Filiz] Tokat State Hosp, Dept Psychiat, Tokat, Turkey.
   [Zorlu, Cagri] Tokat State Hosp, Dept Cardiol, Tokat, Turkey.
   [Kaya, Suheda] Elazig Mental Hlth & Dis Hosp, Dept Psychiat, Elazig, Turkey.
C3 Tokat State Hospital; Tokat State Hospital; Elazig Mental Health &
   Diseases Hospital
RP Özsoy, F (corresponding author), Tokat State Hosp, Dept Psychiat, Tokat, Turkey.
EM flzkoseoglu82@gmail.com
RI Kaya, Şüheda/GRY-2959-2022
OI OZSOY, FILIZ/0000-0002-5198-8827
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NR 37
TC 4
Z9 4
U1 0
U2 19
PU AVES
PI SISLI
PA BUYUKDERE CAD 105-9, MECIDIYEKOY, SISLI, ISTANBUL 34394, TURKEY
EI 2757-8038
J9 ALPHA PSYCHIAT
JI Alpha Psychiat.
PD MAR
PY 2021
VL 22
IS 2
BP 85
EP 89
DI 10.5455/apd.7015
PG 5
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA RG4PK
UT WOS:000635522200004
PM 36425932
OA Green Published
DA 2025-06-11
ER

PT J
AU Mansur, RB
   Lee, Y
   Subramaniapillai, M
   Cha, DS
   Brietzke, E
   McIntyre, RS
AF Mansur, Rodrigo B.
   Lee, Yena
   Subramaniapillai, Mehala
   Cha, Danielle S.
   Brietzke, Elisa
   McIntyre, Roger S.
TI Parsing metabolic heterogeneity in mood disorders: A hypothesis-driven
   cluster analysis of glucose and insulin abnormalities
SO BIPOLAR DISORDERS
LA English
DT Article
DE bipolar disorder; cluster analysis; glucotoxicity; insulin resistance;
   major depressive disorder; metabolic dysregulation; mood disorder;
   subgroup
ID CALORIE RESTRICTION; INTRANASAL INSULIN; CONTROLLED-TRIAL; DOUBLE-BLIND;
   RESISTANCE; INDIVIDUALS; ASSOCIATION; DEPRESSION; OBESITY; OVERWEIGHT
AB Objectives Metabolically based distinctions for disturbances in glucose and insulin may provide meaningful insights both clinically and mechanistically. Methods Data were derived from 352 subjects of previously completed clinical studies with a mood disorder (MD) (bipolar disorder: n = 179, major depressive disorder: n = 173) and 218 healthy controls from the Comprehensive Assessment of Long-Term Effects of Reducing Intake of Energy. We conducted a factor analysis to replicate a priori dissociable factors informed by glucose and insulin levels and indices of insulin resistance and beta-cell function: elevated insulin and insulin resistance ("insulin-IR"), and increased fasting glucose and reduced insulin secretion ("glucotoxicity"). Cluster analyses were conducted, separately in men and women, to evaluate the clinical relevance of subtyping individuals with MDs using insulin-IR and glucotoxicity (GT) factor scores. Results Factors insulin-IR and GT explained 92.64% and 92.09% of the variance in men and women respectively. Three clusters were replicated in men and women separately: metabolically healthy (MH), high GT, and insulin-resistant (IR). After adjusting for age, gender, study cohort, MD diagnosis, and antipsychotics use, body mass index (BMI) and mean arterial pressure were higher in IR- vs GT- or MH-clustered individuals; GT-clustered individuals had more metabolic syndrome components and higher C-reactive protein. Glucotoxic-clustered subjects reported greater impairments in cognitive function and global functioning when compared to MH- or IR-clustered subjects. Conclusions Using simple, cost-effective, and accessible measures, we identified stable, gender-convergent, subgroups of individuals that significantly diverged on measures of cognitive dysfunction, self-reported anhedonia, functional disability, BMI, and blood pressure.
C1 [Mansur, Rodrigo B.; Lee, Yena; Subramaniapillai, Mehala; Cha, Danielle S.; Brietzke, Elisa; McIntyre, Roger S.] Univ Hlth Network, Mood Disorders Psychopharmacol Unit, Toronto, ON, Canada.
   [Mansur, Rodrigo B.; Lee, Yena; McIntyre, Roger S.] Univ Toronto, Dept Psychiat, Toronto, ON, Canada.
   [Brietzke, Elisa] Queens Univ, Dept Psychiat, Kingston, ON, Canada.
   [Brietzke, Elisa] Univ Fed Sao Paulo, Dept Psychiat, Res Grp Mol & Behav Neurosci Mood Disorders, Sao Paulo, Brazil.
   [McIntyre, Roger S.] Brain & Cognit Discovery Fdn, Toronto, ON, Canada.
C3 University of Toronto; University Health Network Toronto; University of
   Toronto; Queens University - Canada; Universidade Federal de Sao Paulo
   (UNIFESP)
RP Mansur, RB (corresponding author), 399 Bathurst St,MP 9-325, Toronto, ON M5T 2S8, Canada.
EM rodrigo.mansur@uhn.ca
RI McIntyre, Roger/AAU-1000-2020; Lee, Yena/L-5505-2019; Brietzke,
   Elisa/G-9559-2012; Mansur, Rodrigo/N-7131-2019
OI Lee, Yena/0000-0003-0629-9456
CR Ahlqvist E, 2018, LANCET DIABETES ENDO, V6, P361, DOI 10.1016/S2213-8587(18)30051-2
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   *US NAT LIVB MED C, THINC IT VORT SENS C
   VANCAMPFORT D, 2015, DEPRESSION
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NR 35
TC 15
Z9 15
U1 0
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1398-5647
EI 1399-5618
J9 BIPOLAR DISORD
JI Bipolar Disord.
PD FEB
PY 2020
VL 22
IS 1
BP 79
EP 88
DI 10.1111/bdi.12826
EA SEP 2019
PG 10
WC Clinical Neurology; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA KO0KY
UT WOS:000487435200001
PM 31464359
DA 2025-06-11
ER

PT J
AU Chang, HH
   Chen, PS
   Wang, TY
   Lee, SY
   Chen, SL
   Huang, SY
   Hong, JS
   Yang, YK
   Lu, RB
AF Chang, Hui Hua
   Chen, Po See
   Wang, Tzu-Yun
   Lee, Sheng-Yu
   Chen, Shiou-Lan
   Huang, San-Yuan
   Hong, Jau-Shyong
   Yang, Yen Kuang
   Lu, Ru-Band
TI Effect of memantine on C-reactive protein and lipid profiles in bipolar
   disorder
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Bipolar disorder; Memantine; C-reactive protein; Metabolic disturbance
ID PLACEBO-CONTROLLED TRIAL; N-ACETYL CYSTEINE; II DISORDER; DEPRESSIVE
   SYMPTOMS; INSULIN-RESISTANCE; COGNITIVE FUNCTION; METABOLIC SYNDROME;
   MAJOR DEPRESSION; INFLAMMATION; ASSOCIATION
AB Background: Balance in the immune system plays roles in bipolar disorder (BD) and its metabolic co-morbidities. Memantine is an NMDA receptor antagonist with anti-inflammatory effects. However, the effects of memantine adjunct treatment on metabolic status of BD are unclear.
   Methods: During the 12 weeks period, a total of 191 BD patients were enrolled and split into valproate (VPA) + placebo and VPA+ memantine (5 mg/day) arms. The fasting plasma levels of high-sensitivity C-reactive protein (CRP) and metabolic indices were assessed. BD patients were stratified according to their initial CRP level.
   Results: A cut-off value of initial CRP level of 2322 ng/mL discriminated the waist circumference in these BD patients after 12-week VPA treatment. In the high CRP (> 2322 ng/mL) group, patients in the VPA + memantine arm had a significantly decreased in their CRP (p=0.009), total cholesterol (p= 0.002), LDL (p= 0.002) levels, BMI (p= 0.001), and waist circumference (p< 0.001), compared to those in the VPA + placebo arm. However, analysis of the low CRP group did not showed the effect.
   Limitations: We recruited BD patients in depressed states and the sample size was relative small. The effects of the fixed dose of memantine on metabolic indices were 12-week follow up in BD patients treated with VPA.
   Conclusions: BD patients with high initial CRP levels receiving memantine adjunct treatment have a reduced risk of inflammation and metabolic imbalance. Prospective studies are needed to confirm the long-term outcome for memantine adjunct therapy in BD patients.
C1 [Chang, Hui Hua] Natl Cheng Kung Univ, Inst Clin Pharm & Pharmaceut Sci, Coll Med, Tainan, Taiwan.
   [Chang, Hui Hua] Natl Cheng Kung Univ, Sch Pharm, Coll Med, Tainan, Taiwan.
   [Chen, Po See; Wang, Tzu-Yun; Yang, Yen Kuang; Lu, Ru-Band] Natl Cheng Kung Univ, Natl Cheng Kung Univ Hosp, Dept Psychiat, Coll Med, Tainan, Taiwan.
   [Chen, Po See; Wang, Tzu-Yun; Yang, Yen Kuang; Lu, Ru-Band] Natl Cheng Kung Univ, Addict Res Ctr, Tainan, Taiwan.
   [Lee, Sheng-Yu] Kaohsiung Vet Gen Hosp, Dept Psychiat, Kaohsiung, Taiwan.
   [Chen, Shiou-Lan] Kaohsiung Med Univ, Sch Med, Dept Neurol, Kaohsiung, Taiwan.
   [Huang, San-Yuan] Triserv Gen Hosp, Dept Psychiat, Natl Def Med Ctr, Taipei, Taiwan.
   [Hong, Jau-Shyong] NIEHS, Lab Pharmacol & Chem, NIH, POB 12233, Res Triangle Pk, NC 27709 USA.
   [Yang, Yen Kuang] Natl Cheng Kung Univ Hosp, Dept Psychiat, Dou Liou Branch, Yunlin, Taiwan.
   [Yang, Yen Kuang] Natl Cheng Kung Univ, Inst Behav Med, Coll Med, Tainan, Taiwan.
C3 National Cheng Kung University; National Cheng Kung University; National
   Cheng Kung University; National Cheng Kung University Hospital; National
   Cheng Kung University; Kaohsiung Veterans General Hospital; Kaohsiung
   Medical University; National Defense Medical Center; Tri-Service General
   Hospital; National Institutes of Health (NIH) - USA; NIH National
   Institute of Environmental Health Sciences (NIEHS); National Cheng Kung
   University; National Cheng Kung University Hospital; National Cheng Kung
   University
RP Chen, PS (corresponding author), Natl Cheng Kung Univ Hosp, Dept Psychiat, 138 Sheng Li Rd, Tainan 70403, Taiwan.
EM chenps@mail.ncku.edu.tw
RI Chen, Shih-Heng/J-6429-2015; Chen, Han-Shen/E-5881-2018; Chang,
   Hui/AGD-4270-2022; Chen, Po/AAA-6492-2021; Hong, Jau-Shyong/F-1920-2019
OI Chang, Hui Hua/0000-0001-7866-5481; Chen, Shiou Lan/0000-0003-3995-0276;
   Hong, Jau-Shyong/0000-0002-3056-8401
FU National Science Council of Taiwan [NSC 98-2627-B006-016, NSC
   99-2627-B-006-014, NSC 100-2627-B-006-012, NSC 101-2314-B-006-064-MY3];
   Ministry of Science and Technology of Taiwan [MOST 104-2320-B-006-024,
   MOST 105-2320-B-006-014]; National Cheng Kung University Hospital
   [NCKUH-10301003, NCKUH-10509004]; Headquarters of University Advancement
   at the National Cheng Kung University - Ministry of Education, Taiwan
   [D102-35001, D103-35A09]
FX This study was financially supported by the National Science Council of
   Taiwan NSC 98-2627-B006-016, NSC 99-2627-B-006-014, NSC
   100-2627-B-006-012, and NSC 101-2314-B-006-064-MY3), the Ministry of
   Science and Technology of Taiwan (MOST 104-2320-B-006-024 and MOST
   105-2320-B-006-014), and National Cheng Kung University Hospital
   (NCKUH-10301003 and NCKUH-10509004). This research also received funding
   (D102-35001 and D103-35A09) from the Headquarters of University
   Advancement at the National Cheng Kung University, which is sponsored by
   the Ministry of Education, Taiwan.
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NR 50
TC 3
Z9 3
U1 0
U2 8
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD OCT 15
PY 2017
VL 221
BP 151
EP 157
DI 10.1016/j.jad.2017.05.052
PG 7
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA FB9MW
UT WOS:000406464200020
PM 28646711
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Walker, LM
   Tran, S
   Wassersug, RJ
   Thomas, B
   Robinson, JW
AF Walker, Lauren M.
   Tran, Susan
   Wassersug, Richard J.
   Thomas, Bejoy
   Robinson, John W.
TI Patients and partners lack knowledge of androgen deprivation therapy
   side effects
SO UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
LA English
DT Article
DE Androgen deprivation therapy; Prostate cancer; Patient education
ID PROSTATE-CANCER PATIENTS; MEN; HEALTH; CONCORDANCE; ADJUSTMENT;
   EXERCISE; IMPROVE
AB Objective: Androgen deprivation therapy (ADT) is the primary treatment for advanced prostate cancer (CaP). There is growing evidence that ADT negatively affects men's psychosocial well-being (e.g., causing sexual dysfunction, bodily feminization) and physical health (e.g., increasing the risk of osteoporosis and metabolic syndrome). Although strategies for managing the majority of side effects exist, it is not clear that patients are benefiting from this knowledge.
   Methods: Seventy-nine newly prescribed ADT patients and 54 of their partners were given a checklist of various common and uncommon ADT side effects. They were asked to indicate the drug side effects that they had heard of or anticipated.
   Results: Both patients and their partners were poorly informed about the side effects of luteinizing hormone-releasing hormone (LHRH) agonists used for ADT. More than 70% did not know that anemia, memory problems, loss of body hair, and depression can occur following treatment. Over 50% were unaware of significant potential side effects such as reduced muscle mass, osteoporosis, increased fracture risk, weight gain, genital shrinkage, and gynecomastia. Concurrently, more than 20% mistakenly anticipated dizziness and itching.
   Conclusion: The lack of awareness of ADT side effects may partially explain why ADT currently results in significant decreases in the quality of life of patients and their partners. Patients uninformed about side effects do not engage in behaviors to prevent or reduce the risk of adverse effects. Improved efforts to educate patients about treatment side effects and coping strategies may result in improved psychosocial and physical health for CaP patients undergoing ADT. Crown Copyright (C) 2013 Published by Elsevier Inc. All rights reserved.
C1 [Walker, Lauren M.; Tran, Susan; Robinson, John W.] Univ Calgary, Dept Psychol, Calgary, AB T2N 1N4, Canada.
   [Walker, Lauren M.; Tran, Susan; Thomas, Bejoy; Robinson, John W.] Tom Baker Canc Clin, Dept Psychosocial Resources, Calgary, AB, Canada.
   [Thomas, Bejoy; Robinson, John W.] Univ Calgary, Fac Med, Calgary, AB, Canada.
   [Wassersug, Richard J.] Dalhousie Univ, Dept Neurobiol & Anat, Halifax, NS, Canada.
   [Wassersug, Richard J.] La Trobe Univ, Australian Res Ctr Sex Hlth & Soc, Melbourne, Vic, Australia.
C3 University of Calgary; University of Calgary; Tom Baker Cancer Clinic;
   University of Calgary; Dalhousie University; La Trobe University
RP Walker, LM (corresponding author), Univ Calgary, Dept Psychol, 2500 Univ Dr NW, Calgary, AB T2N 1N4, Canada.
EM lmwalker@ucalgary.ca
RI WALKER, Lauren/KIL-7055-2024
OI Walker, Lauren/0000-0001-9548-0999
CR ARRINGTON MI, 2003, SEXUALITY CULTURE, P31
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   Wittmann D, 2009, INT J IMPOT RES, V21, P275, DOI 10.1038/ijir.2009.32
NR 46
TC 30
Z9 31
U1 0
U2 8
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1078-1439
EI 1873-2496
J9 UROL ONCOL-SEMIN ORI
JI Urol. Oncol.-Semin. Orig. Investig.
PD OCT
PY 2013
VL 31
IS 7
BP 1098
EP 1105
DI 10.1016/j.urolonc.2011.12.015
PG 8
WC Oncology; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Oncology; Urology & Nephrology
GA 234SJ
UT WOS:000325664300023
PM 22285008
DA 2025-06-11
ER

PT J
AU Charles, LE
   Fekedulegn, D
   McCall, T
   Burchfiel, CM
   Andrew, ME
   Violanti, JM
AF Charles, Luenda E.
   Fekedulegn, Desta
   McCall, Terika
   Burchfiel, Cecil M.
   Andrew, Michael E.
   Violanti, John M.
TI Obesity, white blood cell counts, and platelet counts among police
   officers
SO OBESITY
LA English
DT Article
DE central obesity; adiposity; BMI; epidemiology; hematology
ID BODY-MASS INDEX; SERUM LEPTIN CONCENTRATION; TYPE-2 DIABETIC-PATIENTS;
   LEUKOCYTE COUNT; CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; FAT
   DISTRIBUTION; RISK-FACTORS; WEIGHT-LOSS; MEN
AB Objective: To determine the association between several obesity indices (BMI, waist circumference, waist-to-hip and waist-to-height ratios, and abdominal height) and hematologic parameters [white blood cell (WBC) and platelet counts] among police officers.
   Research Methods and Procedures: The authors conducted this cross-sectional study among 104 randomly selected officers (41 women and 63 men) from the Buffalo, NY, Police Department. Anthropometric measures were performed by clinic staff, and fasting blood samples were drawn for complete blood counts. Pearson's correlation, Student's t tests, ANOVA, analysis of covariance, and linear regression were used to assess the associations.
   Results: Officers ranged in age from 26 to 61 years old and were predominantly white. Among women, current smokers had significantly higher WBC counts (7.4 X 10(3) cells/mu L +/- 1.4) than former (5.2 X 10(3) cells/mu L +/- 1.4) or never smokers (5.6 x 10(3) cells/mu L +/- 1.5) (p = 0.002). Women had similar WBC counts but higher mean platelet counts than men (p = 0.005). Among women, abdominal height was positively associated with platelet count after adjustment for depression (p for trend = 0.039). Among women and men, a non-significant step-wise trend was observed between abdominal height and mean WBC counts before and after adjustment for smoking, race, and physical activity. No association was observed between obesity and platelet count among men.
   Discussion: Abdominal height was significantly associated with increased platelet counts among female officers. No significant associations were observed between obesity and WBC or platelet counts among male officers.
C1 [Charles, Luenda E.; Fekedulegn, Desta; Burchfiel, Cecil M.; Andrew, Michael E.] NIOSH, Ctr Dis Control & Prevent, Hlth Effects Lab Div, Biostat & Epidemiol Branch, Morgantown, WV 26505 USA.
   [Violanti, John M.] SUNY Buffalo, Sch Publ Hlth & Hlth Profess, Dept Social & Prevent Med, Buffalo, NY USA.
C3 Centers for Disease Control & Prevention - USA; National Institute for
   Occupational Safety & Health (NIOSH); State University of New York
   (SUNY) System; University at Buffalo, SUNY
RP Charles, LE (corresponding author), NIOSH, HELD, 1095 Willowdale Rd, Morgantown, WV 26505 USA.
EM lcharles@cdc.gov
RI Charles, Luenda/H-6008-2011
OI McCall, Terika/0000-0002-8143-5393
FU PHS HHS [HELD01B0088] Funding Source: Medline; NIOSH CDC HHS [R03
   OH003772] Funding Source: Medline
CR [Anonymous], 2017, Annex 3-03, P4
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NR 43
TC 28
Z9 32
U1 0
U2 7
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1930-7381
EI 1930-739X
J9 OBESITY
JI Obesity
PD NOV
PY 2007
VL 15
IS 11
BP 2846
EP 2854
DI 10.1038/oby.2007.338
PG 9
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 243EX
UT WOS:000251779000039
PM 18070777
OA Bronze
DA 2025-06-11
ER

PT J
AU Isik, AT
   Celik, T
   Ulusoy, G
   Ongoru, O
   Elibol, B
   Doruk, H
   Bozoglu, E
   Kayir, H
   Mas, MR
   Akman, S
AF Isik, Ahmet Turan
   Celik, Turgay
   Ulusoy, Gokhan
   Ongoru, Onder
   Elibol, Birsen
   Doruk, Huseyin
   Bozoglu, Ergun
   Kayir, Hakan
   Mas, Mehmet Refik
   Akman, Serif
TI Curcumin ameliorates impaired insulin/IGF signalling and memory deficit
   in a streptozotocin-treated rat model
SO AGE
LA English
DT Article
DE Alzheimer's disease; Curcumin; Experimental; IGF-1; Streptozotocin
ID GROWTH-FACTOR EXPRESSION; ALZHEIMERS-DISEASE; COGNITIVE IMPAIRMENT;
   GLUCOSE-METABOLISM; OXIDATIVE STRESS; BETA OLIGOMERS; HIPPOCAMPUS;
   DYSFUNCTION; RELEVANCE; EFFICACY
AB Increased serum insulin levels and reduced peripheral insulin activities seen in insulin resistance syndrome are associated with age-dependent cognitive impairment and Sporadic Alzheimer's Disease (SAD), suggesting a disturbance in the insulin signalling system in the brain and possibly being one of the causes of dementia. Therefore, the streptozotocin (STZ)-induced animal may be an appropriate model for the investigation of SAD and related dementia. This study was designed to investigate the beneficial effect of Curcumin (CUR), a neuroprotective agent, on intracerebroventricular (ICV) STZ-induced cognitive impairment in rats. For this purpose, adult male Wistar rats were bilaterally ICV injected with STZ (3 mg/kg). An artificial cerebrospinal fluid (aCSF) was given to the control group (SHAM) instead of STZ on days 1 and 3. Learning and memory performance were assessed using the "passive avoidance task" and the "Morris water maze test". After confirmation of acquisition impairment with these tests, the STZ group was divided into two subgroups: STZ + vehicle (Vh) and STZ + CUR. The rats in the SHAM and STZ + Vh groups were administered intraperitoneally with 0.5 ml Vh and the rats in the STZ + CUR group were treated intraperitoneally with CUR (300 mg kg(-1) day(-1) in Vh) for 10 days starting from the 25th day after STZ injection. The Morris water maze test was reapplied on the 35th day after STZ injection and all of the rats were sacrificed on day 36 for quantitation of IGF-1 and for histopathological evaluation. Rats in the STZ + CUR group were found to have a higher performance in cognitive tests than rats in the STZ + Vh group (P < 0.01). In parallel with the cognitive tests, IGF-1 levels were decreased in all of the STZ-injected groups (1.78 +/- 0.34) compared to the SHAM group (3.46 +/- 0.41). In contrast, CUR treatment significantly increased IGF-1 levels (P < 0.001). The degree of neuronal loss decreased after CUR treatment compared to the SHAM group (P < 0.02). These results clearly indicate that CUR treatment is effective in reducing the cognitive impairment caused by STZ in rats, and may be a potential therapeutic agent for altering neurodegeneration in SAD.
C1 [Isik, Ahmet Turan; Doruk, Huseyin; Bozoglu, Ergun; Mas, Mehmet Refik] GATA Geriatri BD, Gulhane Sch Med, Div Geriatr Med, Dept Internal Med, TR-06018 Ankara, Turkey.
   [Celik, Turgay; Ulusoy, Gokhan; Kayir, Hakan] Gulhane Mil Med Acad, Dept Pharmacol, Ankara, Turkey.
   [Ongoru, Onder] Gulhane Mil Med Acad, Dept Pathol, Ankara, Turkey.
   [Elibol, Birsen] Middle E Tech Univ, Dept Biol Sci, TR-06531 Ankara, Turkey.
   [Akman, Serif] Gulhane Mil Med Acad, Div Gerontol, Dept Biochem, Ankara, Turkey.
C3 Gulhane Military Medical Academy; Gulhane Military Medical Academy;
   Gulhane Military Medical Academy; Middle East Technical University;
   Gulhane Military Medical Academy
RP Isik, AT (corresponding author), GATA Geriatri BD, Gulhane Sch Med, Div Geriatr Med, Dept Internal Med, TR-06018 Ankara, Turkey.
EM ahmetturanisik@yahoo.com
RI ISIK, Ahmet Turan/AFL-8897-2022; Doruk, Huseyin/AAD-8665-2021; Ulusoy,
   Kemal Gokhan/AAQ-1253-2021; Elibol, Birsen/C-8369-2018; KAYIR,
   Hakan/C-1589-2009; Celik, Turgay/I-2981-2019
OI Ulusoy, Kemal Gokhan/0000-0003-1786-2945; Elibol,
   Birsen/0000-0002-9462-0862; Celik, Turgay/0000-0003-2787-2485; KAYIR,
   Hakan/0000-0002-6423-4207; ISIK, Ahmet Turan/0000-0001-5867-6503; Celik,
   Turgay/0000-0001-8418-0130; DORUK, HUSEYIN/0000-0003-3534-2628
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NR 43
TC 66
Z9 73
U1 0
U2 18
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0161-9152
EI 1574-4647
J9 AGE
JI Age
PD MAR
PY 2009
VL 31
IS 1
BP 39
EP 49
DI 10.1007/s11357-008-9078-8
PG 11
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA 411JD
UT WOS:000263644800004
PM 19234767
OA Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Wang, LN
   Tao, H
   Zhao, Y
   Zhou, YQ
   Jiang, XR
AF Wang, Li-Na
   Tao, Hong
   Zhao, Yue
   Zhou, Yu-Qiu
   Jiang, Xiu-Rong
TI Optimal Timing for Initiation of Biofeedback-Assisted Relaxation
   Training in Hospitalized Coronary Heart Disease Patients With Sleep
   Disturbances
SO JOURNAL OF CARDIOVASCULAR NURSING
LA English
DT Article
DE biofeedback; coronary heart disease; dyssomnias; psychology; inpatients;
   relaxation
ID QUALITY-OF-LIFE; METABOLIC SYNDROME; ANXIETY DISORDERS; COMORBID
   INSOMNIA; CLINICAL-PRACTICE; ARTERY-DISEASE; RISK; POPULATION;
   INSTRUMENT; PREDICTORS
AB Background: Clinical studies have shown that biofeedback-assisted relaxation positively influences the treatment outcomes of sleep disturbance. However, there are only few studies reporting the timing of relaxation training initiation, and the relationships between the timing of initiation and the effectiveness of relaxation remain unclear. Objectives: The aim of this study was to determine the optimal timing for initiating nurse-led biofeedback-assisted relaxation on hospitalized coronary heart disease patients with sleep disturbance. Methods: An experimental pretest and repeated posttest design was used to compare the effectiveness of nurse-led biofeedback-assisted relaxation. A total of 128 patients with coronary heart disease were randomly assigned to 1 of 4 groups: morning group, night group, morning-night group, or control group. Outcome measures included self-report of sleep-related indicators, the scores of the Pittsburgh Sleep Quality Index (PSQI) and the Zung's Self-rating Anxiety Scale (SAS), and the dosage of sleep medication used. A 2-way analysis of variance and a simple effect test were used to analyze the differences among the 4 groups. Results: No significant differences could be detected at baseline. Compared with the control group, the nurse-led biofeedback-assisted relaxation yielded a greater benefit for patients in the 3 intervention groups. Group and time factors (pretest-protest) could explain the variation in the effectiveness of this program (main effect P < .01). There were statistical differences among the groups: patients in the night group (F-SOL = 33.15, P < .001; F-TST = 17.99, P < .001; F-SF = 10.26, P = .002; F-PSQI = 27.38, P < .001; F-SAS = 54.39, P < .001, respectively) and in the morning-night group (F-SOL = 33.62, P < .001; F-TST = 34.13, P < .001; F-SE = 24.04, P < .001; F-PSQI = 31.26, P < .001; F-SAS = 73.93, P < .001, respectively) had slightly shorter sleep latency, experienced fewer awakenings, reported higher sleep quality, and used significantly fewer sleep medications than the morning group did (F = 32.97, P < .001). Conclusions: The timing of the initiation of nurse-led biofeedback-assisted relaxation was 1 of the factors affecting the effectiveness of relaxation. Relaxation training either at night or in the morning-night combination could effectively enhance sleep quality and decrease the need for of sleep medications in hospitalized patients with sleep disturbance.
C1 [Wang, Li-Na] Chifeng Univ, Coll Med, Sch Nursing, Inner Mongolia, Peoples R China.
   [Tao, Hong] Univ Wisconsin Milwaukee, Coll Nursing, Milwaukee, WI USA.
   [Zhao, Yue] Tianjin Med Univ, Sch Nursing, Tianjin, Peoples R China.
   [Zhou, Yu-Qiu] Harbin Med Univ, Sch Nursing, Daqing 163319, Peoples R China.
   [Jiang, Xiu-Rong] Harbin Med Univ, Affiliated Hosp 5, Daqing 163319, Peoples R China.
C3 Chifeng University; University of Wisconsin System; University of
   Wisconsin Milwaukee; Tianjin Medical University; Harbin Medical
   University; Harbin Medical University
RP Zhou, YQ (corresponding author), Harbin Med Univ, Sch Nursing, Daqing Campus,Xinyang Rd, Daqing 163319, Peoples R China.
EM aring2000@163.com
FU Department of Public Health of Heilongjiang Province Foundation
   [2009266]
FX This study was supported by a grant from Department of Public Health of
   Heilongjiang Province Foundation (grant no. 2009266).
   Contributions-study design: L.N.W., H. T., Y.Z., Y.Q.Z.; data collection
   and analysis: L.N.W., X.R.J., Y.Q.Z.; manuscript preparation: L.N.W., H.
   T., Y.Z. All authors read and approved the final manuscript.
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NR 40
TC 11
Z9 12
U1 0
U2 25
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0889-4655
EI 1550-5049
J9 J CARDIOVASC NURS
JI J. Cardiovasc. Nurs.
PD JUL
PY 2014
VL 29
IS 4
BP 367
EP 376
DI 10.1097/JCN.0b013e318297c41b
PG 10
WC Cardiac & Cardiovascular Systems; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Cardiovascular System & Cardiology; Nursing
GA AK3PU
UT WOS:000338338000015
PM 23782864
DA 2025-06-11
ER

PT J
AU Ren, ZL
   Li, CX
   Ma, CY
   Chen, D
   Chen, JH
   Xu, WX
   Chen, CA
   Cheng, FF
   Wang, XQ
AF Ren, Zi-Lin
   Li, Chang-Xiang
   Ma, Chong-Yang
   Chen, Dan
   Chen, Jia-Hui
   Xu, Wen-Xiu
   Chen, Cong-Ai
   Cheng, Fa-Feng
   Wang, Xue-Qian
TI Linking Nonalcoholic Fatty Liver Disease and Brain Disease: Focusing on
   Bile Acid Signaling
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE NAFLD; brain disease; bile acids; FXR; GPBAR1
ID GLUCAGON-LIKE PEPTIDE-1; RECEPTOR-EXPRESSING CELLS; ELEMENT-BINDING
   PROTEIN; ACUTE ISCHEMIC-STROKE; TAUROURSODEOXYCHOLIC ACID;
   URSODEOXYCHOLIC ACID; METABOLIC SYNDROME; ALPHA-5-BETA-1 INTEGRIN;
   NEUROTROPHIC FACTOR; EXPERIMENTAL-MODELS
AB A metabolic illness known as non-alcoholic fatty liver disease (NAFLD), affects more than one-quarter of the world's population. Bile acids (BAs), as detergents involved in lipid digestion, show an abnormal metabolism in patients with NAFLD. However, BAs can affect other organs as well, such as the brain, where it has a neuroprotective effect. According to a series of studies, brain disorders may be extrahepatic manifestations of NAFLD, such as depression, changes to the cerebrovascular system, and worsening cognitive ability. Consequently, we propose that NAFLD affects the development of brain disease, through the bile acid signaling pathway. Through direct or indirect channels, BAs can send messages to the brain. Some BAs may operate directly on the central Farnesoid X receptor (FXR) and the G protein bile acid-activated receptor 1 (GPBAR1) by overcoming the blood-brain barrier (BBB). Furthermore, glucagon-like peptide-1 (GLP-1) and the fibroblast growth factor (FGF) 19 are released from the intestine FXR and GPBAR1 receptors, upon activation, both of which send signals to the brain. Inflammatory, systemic metabolic disorders in the liver and brain are regulated by the bile acid-activated receptors FXR and GPBAR1, which are potential therapeutic targets. From a bile acid viewpoint, we examine the bile acid signaling changes in NAFLD and brain disease. We also recommend the development of dual GPBAR1/FXR ligands to reduce side effects and manage NAFLD and brain disease efficiently.
C1 [Ren, Zi-Lin; Li, Chang-Xiang; Chen, Dan; Xu, Wen-Xiu; Cheng, Fa-Feng; Wang, Xue-Qian] Beijing Univ Chinese Med, Sch Tradit Chinese Med, Beijing 100029, Peoples R China.
   [Ma, Chong-Yang] Capital Med Univ, Sch Tradit Chinese Med, Beijing 100069, Peoples R China.
   [Chen, Jia-Hui; Chen, Cong-Ai] Beijing Univ Tradit Chinese Med, Dongzhimen Hosp, Beijing 100700, Peoples R China.
C3 Beijing University of Chinese Medicine; Capital Medical University;
   Beijing University of Chinese Medicine
RP Cheng, FF; Wang, XQ (corresponding author), Beijing Univ Chinese Med, Sch Tradit Chinese Med, Beijing 100029, Peoples R China.
EM fafengcheng@gmail.com; shirlyding@163.com
RI Chen, Jiahui/AAP-8128-2021
OI Wang, Xueqian/0000-0002-7682-3877
FU National Natural Science Foundation of China (NSFC) [8197151084,
   8200142456, 82004327, U21A20400]; Projects of Beijing University of
   Chinese Medicine [2022-JYB-JBZR-004]
FX The present study was supported by grants from the National Natural
   Science Foundation of China (NSFC)(8197151084, 8200142456, 82004327,
   U21A20400) and Projects of Beijing University of Chinese Medicine
   (2022-JYB-JBZR-004).
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NR 222
TC 13
Z9 17
U1 0
U2 41
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD NOV
PY 2022
VL 23
IS 21
AR 13045
DI 10.3390/ijms232113045
PG 24
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 6B1VL
UT WOS:000881129400001
PM 36361829
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Daher-Abdi, A
   Hernández, SO
   Castro, LAR
   Mezo-González, CE
   Croyal, M
   García-Santillán, JA
   Ouguerram, K
   Zambrano, E
   Bolaños-Jiménez, F
AF Daher-Abdi, Amran
   Olvera Hernandez, Sandra
   Reyes Castro, Luis Antonio
   Elena Mezo-Gonzalez, Carla
   Croyal, Mikael
   Antonio Garcia-Santillan, Juan
   Ouguerram, Khadija
   Zambrano, Elena
   Bolanos-Jimenez, Francisco
TI Maternal DHA Supplementation during Pregnancy and Lactation in the Rat
   Protects the Offspring against High-Calorie Diet-Induced Hepatic
   Steatosis
SO NUTRIENTS
LA English
DT Article
DE developmental programming; DHA; obesity; hepatic steatosis
ID POLYUNSATURATED FATTY-ACIDS; DOCOSAHEXAENOIC ACID; FISH-OIL; INSULIN
   SENSITIVITY; SEX-DIFFERENCES; PRENATAL SUPPLEMENTATION; METABOLIC
   SYNDROME; DNA METHYLATION; LIVER-DISEASE; OBESITY
AB Maternal supplementation during pregnancy with docosahexaenoic acid (DHA) is internationally recommended to avoid postpartum maternal depression in the mother and improve cognitive and neurological outcomes in the offspring. This study was aimed at determining whether this nutritional intervention, in the rat, protects the offspring against the development of obesity and its associated metabolic disorders. Pregnant Wistar rats received an extract of fish oil enriched in DHA or saline (SAL) as placebo by mouth from the beginning of gestation to the end of lactation. At weaning, pups were fed standard chow or a free-choice, high-fat, high-sugar (fc-HFHS) diet. Compared to animals fed standard chow, rats exposed to the fc-HFHS diet exhibited increased body weight, liver weight, body fat and leptin in serum independently of saline or DHA maternal supplementation. Nevertheless, maternal DHA supplementation prevented both the glucose intolerance and the rise in serum insulin resulting from consumption of the fc-HFHS diet. In addition, animals from the DHA-fc-HFHS diet group showed decreased hepatic triglyceride accumulation compared to SAL-fc-HFHS rats. The beneficial effects on glucose homeostasis declined with age in male rats. Yet, the preventive action against hepatic steatosis was still present in 6-month-old animals of both sexes and was associated with decreased hepatic expression of lipogenic genes. The results of the present work show that maternal DHA supplementation during pregnancy programs a healthy phenotype into the offspring that was protective against the deleterious effects of an obesogenic diet.
C1 [Daher-Abdi, Amran; Olvera Hernandez, Sandra; Reyes Castro, Luis Antonio; Elena Mezo-Gonzalez, Carla; Antonio Garcia-Santillan, Juan; Ouguerram, Khadija; Bolanos-Jimenez, Francisco] Univ Nantes, UMR Physiol Adaptat Nutritionnelles, INRAE, F-44096 Nantes, France.
   [Olvera Hernandez, Sandra] Autonomous Univ Baja California, Med & Psychol Sch, Tijuana 21100, Mexico.
   [Reyes Castro, Luis Antonio; Zambrano, Elena] Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Reprod Biol Dept, Mexico City 14080, DF, Mexico.
   [Croyal, Mikael] CRNH Mass Spectrometry Core Facil, 8 Quai Moncousu, F-44000 Nantes, France.
   [Croyal, Mikael] Univ Nantes, CNRS, INSERM, Inst Thorax, 8 Quai Moncousu, F-44000 Nantes, France.
   [Croyal, Mikael] Univ Nantes, CHU Nantes, INSERM, SFR Sante,UMS 016,CNRS,UMS 3556, F-44000 Nantes, France.
C3 Nantes Universite; INRAE; Universidad Autonoma de Baja California;
   Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran -
   Mexico; Nantes Universite; CHU de Nantes; Centre National de la
   Recherche Scientifique (CNRS); Institut National de la Sante et de la
   Recherche Medicale (Inserm); Nantes Universite; CHU de Nantes; Centre
   National de la Recherche Scientifique (CNRS); CNRS - National Institute
   for Biology (INSB); Institut National de la Sante et de la Recherche
   Medicale (Inserm)
RP Bolaños-Jiménez, F (corresponding author), Univ Nantes, UMR Physiol Adaptat Nutritionnelles, INRAE, F-44096 Nantes, France.
EM amran.daherabdi@gmail.com; olvera.sandra@uabc.edu.mx;
   lafe_mat@hotmail.com; carla.mezo-gonzalez@etu.univ-nantes.fr;
   Mikael.Croyal@univ-nantes.fr; juantgarsan@hotmail.com;
   khadija.ouguerram@univ-nantes.fr; zamgon@yahoo.com.mx;
   Francisco.Bolanos@univ-nantes.fr
RI Olvera-Hernandez, Sandra/GMW-7119-2022; REYES CASTRO, LUIS
   ANTONIO/E-9896-2019
OI REYES CASTRO, LUIS ANTONIO/0000-0003-0397-6810; Zambrano,
   Elena/0000-0002-0362-9117
FU French National Research Agency (ANR) [ANR-16-CE21-0007-01]; Mexican
   Consejo Nacional de Ciencia y Tecnologia (CONACYT) [2015-16-273510];
   Agence Nationale de la Recherche (ANR) [ANR-16-CE21-0007] Funding
   Source: Agence Nationale de la Recherche (ANR)
FX This research was funded by the French National Research Agency (ANR,
   grant ANR-16-CE21-0007-01) and the Mexican Consejo Nacional de Ciencia y
   Tecnologia (CONACYT, award number 2015-16-273510).
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NR 81
TC 8
Z9 10
U1 1
U2 5
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD SEP
PY 2021
VL 13
IS 9
AR 3075
DI 10.3390/nu13093075
PG 22
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA UX8DS
UT WOS:000701069700001
PM 34578953
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Millier, A
   Sarlon, E
   Azorin, JM
   Boyer, L
   Aballea, S
   Auquier, P
   Toumi, M
AF Millier, Aurelie
   Sarlon, Emmanuelle
   Azorin, Jean-Michel
   Boyer, Laurent
   Aballea, Samuel
   Auquier, Pascal
   Toumi, Mondher
TI Relapse according to antipsychotic treatment in schizophrenic patients:
   a propensity-adjusted analysis
SO BMC PSYCHIATRY
LA English
DT Article
ID CALGARY DEPRESSION SCALE; QUALITY-OF-LIFE; ATYPICAL ANTIPSYCHOTICS;
   METABOLIC SYNDROME; GLOBAL ASSESSMENT; CONTROLLED-TRIALS; COHORT EUROSC;
   HEALTH SURVEY; POLYPHARMACY; MEDICATION
AB Objective: To compare the rate of relapse as a function of antipsychotic treatment (monotherapy vs. polypharmacy) in schizophrenic patients over a 2-year period.
   Methods: Using data from a multicenter cohort study conducted in France, we performed a propensity-adjusted analysis to examine the association between the rate of relapse over a 2-year period and antipsychotic treatment (monotherapy vs. polypharmacy).
   Results: Our sample consisted in 183 patients; 50 patients (27.3%) had at least one period of relapse and 133 had no relapse (72.7%). Thirty-eight (37.7) percent of the patients received polypharmacy. The most severely ill patients were given polypharmacy: the age at onset of illness was lower in the polypharmacy group (p = 0.03). Patients that received polypharmacy also presented a higher general psychopathology PANSS subscore (p = 0.04) but no statistically significant difference was found in the PANSS total score or the PANSS positive or negative subscales. These patients were more likely to be given prescriptions for sedative drugs (p < 0.01) and antidepressant medications (p = 0.03). Relapse was found in 23.7% of patients given monotherapy and 33.3% given polypharmacy (p = 0.16). After stratification according to quintiles of the propensity score, which eliminated all significant differences for baseline characteristics, antipsychotic polypharmacy was not statistically associated with an increase of relapse: HR = 1.686 (0.812; 2.505).
   Conclusion: After propensity score adjustment, antipsychotic polypharmacy is not statistically associated to an increase of relapse. Future randomised studies are needed to assess the impact of antipsychotic polypharmacy in schizophrenia.
C1 [Toumi, Mondher] Univ Lyon 1, UCBL Chair Market Access 1, F-69622 Villeurbanne, France.
   [Millier, Aurelie; Aballea, Samuel] Creativ Ceut France, F-75008 Paris, France.
   [Sarlon, Emmanuelle] INSERM, Natl Inst Hlth & Med Res, U669, F-75679 Paris, France.
   [Sarlon, Emmanuelle] Univ Paris Sud, F-75014 Paris, France.
   [Sarlon, Emmanuelle] Univ Paris 05, UMR S0669, F-75014 Paris, France.
   [Sarlon, Emmanuelle] Ctr Hosp, Dept Publ Hlth, F-60309 Senlis, France.
   [Azorin, Jean-Michel] Univ Hosp Ste Marguerite, Dept Psychiat, F-13009 Marseille, France.
   Univ Hosp, Dept Publ Hlth, Res Unit EA 3279, F-13385 Marseille, France.
C3 Universite Claude Bernard Lyon 1; Universite Paris Cite; Institut
   National de la Sante et de la Recherche Medicale (Inserm); Universite
   Paris Saclay; Universite Paris Cite; Aix-Marseille Universite;
   Aix-Marseille Universite; Assistance Publique-Hopitaux de Marseille
RP Toumi, M (corresponding author), Univ Lyon 1, UCBL Chair Market Access 1, Blvd 11 Novembre 1918, F-69622 Villeurbanne, France.
EM laurent.boyer@ap-hm.fr
RI Boyer, Laurent/E-5728-2016
FU H. Lundbeck A/S
FX The study was funded by H. Lundbeck A/S.
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NR 58
TC 15
Z9 15
U1 0
U2 5
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-244X
J9 BMC PSYCHIATRY
JI BMC Psychiatry
PD FEB 11
PY 2011
VL 11
AR 24
DI 10.1186/1471-244X-11-24
PG 9
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychiatry
GA 727QK
UT WOS:000287815900001
PM 21314943
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Krikorian, R
   Shidler, MD
   Summer, SS
AF Krikorian, Robert
   Shidler, Marcelle D.
   Summer, Suzanne S.
TI Early Intervention in Cognitive Aging with Strawberry Supplementation
SO NUTRIENTS
LA English
DT Article
DE strawberries; anthocyanins; insulin resistance; aging; cognition;
   dementia risk reduction
ID DEPRESSION INVENTORY-II; EXECUTIVE FUNCTION; DEMENTIA PREVENTION;
   METABOLIC SYNDROME; NEURONAL FUNCTION; WORKING-MEMORY; BLUEBERRY;
   ADULTS; RISK; HYPERINSULINEMIA
AB Late-life dementia is a growing public health concern lacking effective treatment. Neurodegenerative disorders such as Alzheimer's disease (AD) develop over a preclinical period of many years beginning in midlife. The prevalence of insulin resistance, a prominent risk factor for late-life dementia, also accelerates in middle-age. Consumption of berry fruits, including strawberries, has been shown to influence metabolism as well as cognitive performance suggesting potential to mitigate risk for dementia. In this controlled trial, we enrolled overweight middle-aged men and women with insulin resistance and subjective cognitive decline and performed a 12-week intervention with daily administration of whole-fruit strawberry powder. Diet records showed that participants in both groups maintained the prescribed abstinence from berry product consumption outside the study. We observed diminished memory interference (p = 0.02; Cohen's f = 0.45) and a reduction of depressive symptoms (p = 0.04; Cohen's f = 0.39) for the strawberry-treated participants; benefits consistent with improved executive ability. However, there was no effect of the intervention on metabolic measures, possibly a consequence of the sample size, length of the intervention, or comparatively low anthocyanin dose. Anti-inflammatory actions of anthocyanins were considered as a primary mechanistic factor. The findings support the notion that strawberry supplementation has a role in dementia risk reduction when introduced in midlife. However, further investigation with longer intervention periods, larger samples, and differing dosing regimens will be required to assess the benefits of strawberry intake with respect to cognition and metabolic function in the context of aging.
C1 [Krikorian, Robert; Shidler, Marcelle D.] Univ Cincinnati, Acad Hlth Ctr, Dept Psychiat & Behav Neurosci, Cincinnati, OH 45267 USA.
   [Summer, Suzanne S.] Cincinnati Childrens Hosp Med Ctr, Schubert Res Clin, Bionutr Core, Cincinnati, OH 45229 USA.
C3 University System of Ohio; University of Cincinnati; Cincinnati
   Children's Hospital Medical Center
RP Krikorian, R (corresponding author), Univ Cincinnati, Acad Hlth Ctr, Dept Psychiat & Behav Neurosci, Cincinnati, OH 45267 USA.
EM robert.krikorian@uc.edu; shidlemd@ucmail.uc.edu;
   suzanne.summer@cchmc.org
FU California Strawberry Commission, Watsonville, California, USA
FX This research was supported with funding and donation of strawberry and
   placebopowders by the California Strawberry Commission, Watsonville,
   California 95076, USA.
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NR 84
TC 9
Z9 9
U1 7
U2 22
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD OCT
PY 2023
VL 15
IS 20
AR 4431
DI 10.3390/nu15204431
PG 15
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA W2HT6
UT WOS:001089900000001
PM 37892506
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Nguyen, TP
   Cribb, L
   Ng, CH
   Byrne, GJ
   Castle, D
   Brakoulias, V
   Blair-West, S
   Oliver, G
   Ee, C
   Dean, OM
   Camfield, DA
   Bousman, C
   Dowling, N
   Roy, R
   Berk, M
   Sarris, J
AF Nguyen, Thomas P.
   Cribb, Lachlan
   Ng, Chee H.
   Byrne, Gerard J.
   Castle, David
   Brakoulias, Vlasios
   Blair-West, Scott
   Oliver, Georgina
   Ee, Carolyn
   Dean, Olivia M.
   Camfield, David A.
   Bousman, Chad
   Dowling, Nathan
   Roy, Rajshri
   Berk, Michael
   Sarris, Jerome
TI Dietary quality and nutrient intake in adults with obsessive-compulsive
   disorder
SO BJPSYCH OPEN
LA English
DT Article
DE Obsessive-compulsive disorder; dietary quality; nutrition; diet;
   psychiatry
ID VITAMIN-D LEVELS; HOMOCYSTEINE LEVELS; METABOLIC SYNDROME; POPULATION;
   SCHIZOPHRENIA; COMPLICATIONS; CALIBRATION; ADOLESCENTS; VALIDATION;
   PSYCHIATRY
AB Background Many mental disorders, including depression, bipolar disorder and schizophrenia, are associated with poor dietary quality and nutrient intake. There is, however, a deficit of research looking at the relationship between obsessive-compulsive disorder (OCD) severity, nutrient intake and dietary quality. Aims This study aims to explore the relationship between OCD severity, nutrient intake and dietary quality. Method A post hoc regression analysis was conducted with data combined from two separate clinical trials that included 85 adults with diagnosed OCD, using the Structured Clinical Interview for DSM-5. Nutrient intakes were calculated from the Dietary Questionnaire for Epidemiological Studies version 3.2, and dietary quality was scored with the Healthy Eating Index for Australian Adults - 2013. Results Nutrient intake in the sample largely aligned with Australian dietary guidelines. Linear regression models adjusted for gender, age and total energy intake showed no significant associations between OCD severity, nutrient intake and dietary quality (all P > 0.05). However, OCD severity was inversely associated with caffeine (beta = -15.50, 95% CI -28.88 to -2.11, P = 0.024) and magnesium (beta = -6.63, 95% CI -12.72 to -0.53, P = 0.034) intake after adjusting for OCD treatment resistance. Conclusions This study showed OCD severity had little effect on nutrient intake and dietary quality. Dietary quality scores were higher than prior studies with healthy samples, but limitations must be noted regarding comparability. Future studies employing larger sample sizes, control groups and more accurate dietary intake measures will further elucidate the relationship between nutrient intake and dietary quality in patients with OCD.
C1 [Nguyen, Thomas P.; Brakoulias, Vlasios] Western Sydney Univ, Sch Med, Sydney, NSW, Australia.
   [Nguyen, Thomas P.; Ee, Carolyn; Sarris, Jerome] Western Sydney Univ, NICM Hlth Res Inst, Sydney, NSW, Australia.
   [Cribb, Lachlan; Ng, Chee H.; Blair-West, Scott; Oliver, Georgina; Dowling, Nathan; Sarris, Jerome] Univ Melbourne, Dept Psychiat, Melbourne Clin, Professorial Unit, Melbourne, Vic, Australia.
   [Byrne, Gerard J.] Univ Queensland, Ctr Clin Res, Royal Brisbane & Womens Hosp, Brisbane, Qld, Australia.
   [Byrne, Gerard J.] Royal Brisbane & Womens Hosp, Mental Hlth Serv, Brisbane, Qld, Australia.
   [Castle, David] Ctr Addict & Mental Hlth, Ctr Complex Intervent, Toronto, ON, Canada.
   [Castle, David] Univ Toronto, Dept Psychiat, Toronto, ON, Canada.
   [Brakoulias, Vlasios] Western Sydney Local Hlth Dist Mental Hlth Serv, Sydney, NSW, Australia.
   [Dean, Olivia M.; Camfield, David A.; Berk, Michael] Deakin Univ, Sch Med, IMPACT Inst Mental & Phys Hlth & Clin Translat, Barwon Hlth, Burwood, Australia.
   [Dean, Olivia M.; Berk, Michael] Florey Inst Neurosci & Mental Hlth, Parkville, Vic, Australia.
   [Bousman, Chad] Univ Melbourne, Dept Psychiat, Melbourne, Vic, Australia.
   [Bousman, Chad] Univ Calgary, Dept Med Genet, Edmonton, AB, Canada.
   [Bousman, Chad] Univ Calgary, Dept Psychiat, Edmonton, AB, Canada.
   [Bousman, Chad] Univ Calgary, Dept Physiol & Pharmacol, Edmonton, AB, Canada.
   [Bousman, Chad] Univ Calgary, Dept Commun Hlth Sci, Edmonton, AB, Canada.
   [Roy, Rajshri] Univ Auckland, Fac Med & Hlth Sci, Discipline Nutr & Dietet, Auckland, New Zealand.
   [Berk, Michael] Orygen Natl Ctr Excellence Youth Mental Hlth, Melbourne, Vic, Australia.
   [Berk, Michael] Univ Melbourne, Ctr Youth Mental Hlth, Melbourne, Vic, Australia.
C3 Western Sydney University; Western Sydney University; University of
   Melbourne; University of Queensland; Royal Brisbane & Women's Hospital;
   Royal Brisbane & Women's Hospital; University of Toronto; Centre for
   Addiction & Mental Health - Canada; University of Toronto; Deakin
   University; Florey Institute of Neuroscience & Mental Health; University
   of Melbourne; University of Calgary; University of Calgary; University
   of Calgary; University of Calgary; University of Auckland; Orygen, The
   National Centre of Excellence in Youth Mental Health; Orygen, The
   National Centre of Excellence in Youth Mental Health; University of
   Melbourne
RP Sarris, J (corresponding author), Western Sydney Univ, NICM Hlth Res Inst, Sydney, NSW, Australia.; Sarris, J (corresponding author), Univ Melbourne, Dept Psychiat, Melbourne Clin, Professorial Unit, Melbourne, Vic, Australia.
EM j.sarris@westernsydney.edu.au
RI Roy, Rajshri/ABK-6272-2022; Dean, Olivia/ADN-9162-2022; Brakoulias,
   Vlasios/N-1603-2019; Cribb, Lachlan/IXW-8184-2023; Bousman,
   Chad/IVH-7388-2023; Berk, Michael/AGH-9427-2022; Ee,
   Carolyn/V-5070-2019; Berk, Michael/M-7891-2013
OI Castle, David/0000-0002-3075-1580; Brakoulias,
   Vlasios/0000-0002-4188-4370; Roy, Rajshri/0000-0002-7939-1790; Cribb,
   Lachlan/0000-0001-5276-5249; Ee, Carolyn/0000-0002-3363-9199; Nguyen,
   Thomas/0000-0002-7691-4461; Berk, Michael/0000-0002-5554-6946; Ng,
   Chee/0000-0002-3811-2732; Dean, Olivia/0000-0002-2776-3935
FU Western Sydney University Summer Research Scholarship; National Health
   and Medical Research Council (NHMRC) Clinical Research Fellowship
   [APP1125000]; NHMRC Biomedical Career Development Fellowship [1145634];
   NHMRC Senior Principal Research Fellowship [1156072]; Jacka Foundation
   of Natural Therapies; NHMRC [APP1104460]; National Health and Medical
   Research Council of Australia [1145634] Funding Source: NHMRC
FX T.P.N. was supported by a Western Sydney University Summer Research
   Scholarship. J.S. is supported by a National Health and Medical Research
   Council (NHMRC) Clinical Research Fellowship (number APP1125000). O.M.D.
   is supported by an R.D. Wright NHMRC Biomedical Career Development
   Fellowship (number 1145634). M.B. is supported by a NHMRC Senior
   Principal Research Fellowship (number 1156072). C.E. is supported by an
   endowment from the Jacka Foundation of Natural Therapies. NHMRC
   APP1104460.
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NR 49
TC 4
Z9 4
U1 1
U2 1
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 2056-4724
J9 BJPSYCH OPEN
JI BJPsych Open
PD NOV 19
PY 2021
VL 7
IS 6
AR e218
DI 10.1192/bjo.2021.1039
PG 8
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA WZ9PX
UT WOS:000720292600001
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Guan, LY
   Hou, WL
   Zhu, ZH
   Cao, JQ
   Tang, Z
   Yin, XY
   Xu, DW
   Yu, X
   Jia, QF
   Tang, WJ
   Zhang, JP
   Hui, L
AF Guan, Lu Yang
   Hou, Wen Long
   Zhu, Zhen Hua
   Cao, Jia Qi
   Tang, Zhen
   Yin, Xu Yuan
   Xu, Dong Wu
   Yu, Xin
   Jia, Qiu Fang
   Tang, Wen Jie
   Zhang, Jian-Ping
   Hui, Li
TI Associations among gonadal hormone, triglycerides and cognitive decline
   in female patients with major depressive disorders
SO JOURNAL OF PSYCHIATRIC RESEARCH
LA English
DT Article
DE Major depressive disorders; Cognitive decline; Triglycerides; Gonadal
   hormone; Female
ID TESTOSTERONE LEVELS; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   SEX-DIFFERENCES; MEMORY TASK; PERFORMANCE; LIPOPROTEIN; ESTRADIOL;
   ESTROGEN; CHOLESTEROL
AB Background: Cognitive impairment has been identified as a core feature of depression. Serum triglycerides (TG), gonadal hormone and sex difference were shown to influence cognitive performance. The purpose of this study was to investigate the associations among serum TG, gonadal hormone, sex difference and cognitive performance in patients with major depressive disorders (MDD). Methods: The enrolled 183 patients (male/female = 80/103) meeting DSM-IV criteria for MDD were divided into high TG group (patients-HTG) and normal TG group (patients-NTG) according to TG level. Serum TG, estradiol (E2) and testosterone (T) levels were measured by the glycerokinase peroxidase-peroxidase and chemiluminescence methods. Cognition was assessed by the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). The study was conducted between August 2016 and January 2020. Results: In female, patients-HTG had lower immediate memory, language, attention, delayed memory and RBANS total scores than patients-NTG after adjusting for covariates. There were significant differences in serum E2 and T levels between patients-HTG and patients-NTG in female after controlling for covariates. In female patients-HTG, serum E2 level was positively associated with immediate memory, delayed memory and RBANS total scores, and serum T level was positively related to immediate memory, language and RBANS total scores. These findings were not seen in male patients. Conclusions: Our data suggested that patients-HTG exhibited poorer cognitive function compared with patientsNTG in female. Moreover, the decline in serum gonadal hormone level might contribute to the high TG development of female MDD, and was further implicated in their cognitive decline.
C1 [Guan, Lu Yang; Hou, Wen Long; Cao, Jia Qi; Xu, Dong Wu; Yu, Xin; Tang, Wen Jie; Hui, Li] Wenzhou Med Univ, Sch Mental Hlth, Sch Clin Med 1, Wenzhou 325035, Zhejiang, Peoples R China.
   [Guan, Lu Yang; Hou, Wen Long; Zhu, Zhen Hua; Cao, Jia Qi; Tang, Zhen; Yin, Xu Yuan; Jia, Qiu Fang; Tang, Wen Jie; Hui, Li] Soochow Univ, Affiliated Guangji Hosp, Res Ctr Biol Psychiat, Suzhou 215137, Jiangsu, Peoples R China.
   [Yu, Xin] Peking Univ, Inst Mental Hlth, Beijing 100083, Peoples R China.
   [Zhang, Jian-Ping] Cornell Univ, Weill Cornell Med Coll, Dept Psychiat, New York, NY 10605 USA.
C3 Wenzhou Medical University; Soochow University - China; Peking
   University; Cornell University; Weill Cornell Medicine
RP Tang, WJ (corresponding author), Wenzhou Med Univ, Sch Mental Hlth, Sch Clin Med 1, Wenzhou 325035, Zhejiang, Peoples R China.; Hui, L (corresponding author), Soochow Univ, Affiliated Guangji Hosp, Res Ctr Biol Psychiat, Suzhou 215137, Jiangsu, Peoples R China.
EM 13606777777@qq.com; huili004100@126.com
RI Zhang, Quan-Ping/Q-1431-2015; Yu, Xinchi/ABC-7745-2020; zhu,
   zh/KFB-9018-2024; yin, xuyuan/KFB-3119-2024
FU National Natural Science Foundation of China [81771439]; Jiangsu
   Provincial Key Research and Development Program [BE2020661, BE2018662];
   Jiangsu Provincial Health Commission Science Research Program
   [QNRC2016228, H2019056, LGY2018010]; Jiangsu Provincial Six Talent Peaks
   Project [WSN-165]; Suzhou Municipal Health Commission Science Research
   Program [SZYJTD201715, LCZX201820, Kjxw2018048, Gwzx201801]; Suzhou
   Municipal Sci-Tech Bureau Program [SZS201722, SS201706, SYS2019113,
   SS2019009]; CAS Key Laboratory of Mental Health, Institute of Psychology
   [KLMH2019K03]
FX This work was supported by the National Natural Science Foundation of
   China (81771439), Jiangsu Provincial Key Research and Development
   Program (BE2020661 and BE2018662), Jiangsu Provincial Health Commission
   Science Research Program (QNRC2016228, H2019056 and LGY2018010), Jiangsu
   Provincial Six Talent Peaks Project (WSN-165), Suzhou Municipal Health
   Commission Science Research Program (SZYJTD201715, LCZX201820,
   Kjxw2018048 and Gwzx201801), Suzhou Municipal Sci-Tech Bureau Program
   (SZS201722, SS201706, SYS2019113 and SS2019009), and CAS Key Laboratory
   of Mental Health, Institute of Psychology (KLMH2019K03).
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NR 62
TC 9
Z9 11
U1 3
U2 19
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-3956
EI 1879-1379
J9 J PSYCHIATR RES
JI J. Psychiatr. Res.
PD NOV
PY 2021
VL 143
BP 580
EP 586
DI 10.1016/j.jpsychires.2020.11.022
EA OCT 2021
PG 7
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA WT2BB
UT WOS:000715673300020
PM 33213891
DA 2025-06-11
ER

PT J
AU An, H
   Yang, HW
   Oh, DJ
   Lim, E
   Shin, J
   Moon, DG
   Suh, SW
   Byun, S
   Kim, TH
   Kwak, KP
   Kim, BJ
   Kim, SG
   Kim, JL
   Moon, SW
   Park, JH
   Ryu, SH
   Lee, DW
   Lee, SB
   Lee, JJ
   Jhoo, JH
   Bae, JB
   Han, JW
   Kim, KW
AF An, Hoyoung
   Yang, Hee Won
   Oh, Dae Jong
   Lim, Eunji
   Shin, Jin
   Moon, Dong Gyu
   Suh, Seung Wan
   Byun, Seonjeong
   Kim, Tae Hui
   Kwak, Kyung Phil
   Kim, Bong Jo
   Kim, Shin Gyeom
   Kim, Jeong Lan
   Moon, Seok Woo
   Park, Joon Hyuk
   Ryu, Seung-Ho
   Lee, Dong Woo
   Lee, Seok Bum
   Lee, Jung Jae
   Jhoo, Jin Hyeong
   Bae, Jong Bin
   Han, Ji Won
   Kim, Ki Woong
TI Mood disorders increase mortality mainly through dementia: A
   community-based prospective cohort study
SO AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
LA English
DT Article
DE Depression; bipolar disorder; dementia; mortality; survival analysis
ID MAJOR DEPRESSIVE DISORDER; HEART-RATE-VARIABILITY; ALZHEIMER-DISEASE;
   BIPOLAR DISORDER; CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME;
   LIFE-STYLE; RISK; HISTORY; BURDEN
AB Objective: The effects of mood disorders on mortality may be mediated by their effects on the risk of dementia, and interventions to reduce the occurrence of dementia may reduce their overall mortality. This study aimed to investigate the direct effects of depressive and bipolar disorders on the 6-year risk of mortality and also their indirect effects on mortality due to their effect on the risk of dementia. Methods: A total of 5101 Koreans were selected from a community-based prospective cohort study, and 6-year risks of mortality and dementia in participants with depressive and bipolar disorders were estimated by Cox proportional hazard analysis. The direct and indirect effects of depressive and bipolar disorders on the risk of mortality were estimated using structural equation modeling. Results: The depressive and bipolar disorder groups showed 51% and 85% higher 6-year mortality, and 82% and 127% higher risk of dementia, respectively, compared to euthymic controls. The effects of depressive and bipolar disorders on mortality were mainly mediated by their effects on the risk of dementia in a structural equation model. The direct effects of each mood disorder on mortality were not significant. Conclusion: Both depressive and bipolar disorders increased the risks of mortality and dementia, and the effects of mood disorders on mortality were mainly mediated through dementia. As dementia occurs later in life than mood disorders, measures to prevent it may effectively reduce mortality in individuals with a history of mood disorders, as well as being more feasible than attempting to control other causes of death.
C1 [An, Hoyoung] Seongnam Sarang Hosp, Seongnam, South Korea.
   [Yang, Hee Won; Lim, Eunji; Shin, Jin; Moon, Dong Gyu; Bae, Jong Bin; Han, Ji Won; Kim, Ki Woong] Seoul Natl Univ, Dept Neuropsychiat, Bundang Hosp, Seongnam, South Korea.
   [Oh, Dae Jong; Kim, Ki Woong] Seoul Natl Univ, Dept Psychiat, Coll Med, Seoul, South Korea.
   [Oh, Dae Jong] SMG SNU Boramae Med Ctr, Dept Psychiat, Seoul, South Korea.
   [Suh, Seung Wan] Hallym Univ, Kangdong Sacred Heart Hosp, Dept Psychiat, Coll Med, Seoul, South Korea.
   [Byun, Seonjeong] Catholic Univ Korea, Uijeongbu St Marys Hosp, Dept Psychiat, Coll Med, Uijongbu, South Korea.
   [Kim, Tae Hui] Yonsei Univ, Dept Psychiat, Wonju Severance Christian Hosp, Wonju, South Korea.
   [Kwak, Kyung Phil] Dongguk Univ, Dept Psychiat, Gyeongju Hosp, Gyeongju, South Korea.
   [Kim, Bong Jo] Gyeongsang Natl Univ, Dept Psychiat, Sch Med, Jinju, South Korea.
   [Kim, Shin Gyeom] Soonchunhyang Univ, Dept Neuropsychiat, Bucheon Hosp, Bucheon, South Korea.
   [Kim, Jeong Lan] Chungnam Natl Univ, Sch Med, Dept Psychiat, Daejeon, South Korea.
   [Moon, Seok Woo] Konkuk Univ, Konkuk Univ Chungju Hosp, Sch Med, Dept Psychiat, Chungju, South Korea.
   [Park, Joon Hyuk] Jeju Natl Univ Hosp, Dept Neuropsychiat, Jeju, South Korea.
   [Ryu, Seung-Ho] Konkuk Univ, Konkuk Univ Med Ctr, Sch Med, Dept Psychiat, Seoul, South Korea.
   [Lee, Dong Woo] Inje Univ, Dept Neuropsychiat, Sanggye Paik Hosp, Seoul, South Korea.
   [Lee, Seok Bum; Lee, Jung Jae] Dankook Univ Hosp, Dept Psychiat, Cheonan, South Korea.
   [Jhoo, Jin Hyeong] Kangwon Natl Univ, Sch Med, Dept Psychiat, Chunchon, South Korea.
   [Kim, Ki Woong] Seoul Natl Univ, Coll Nat Sci, Dept Brain & Cognit Sci, Seoul, South Korea.
C3 Seoul National University (SNU); Seoul National University (SNU); Seoul
   National University (SNU); Seoul National University Hospital; Hallym
   University; Catholic University of Korea; Yonsei University; Dongguk
   University; Gyeongsang National University; Soonchunhyang University;
   Chungnam National University; Konkuk University; Konkuk University
   Medical Center; Jeju National University; Konkuk University; Konkuk
   University Medical Center; Inje University; Dankook University; Dankook
   University Hospital; Kangwon National University; Seoul National
   University (SNU)
RP Kim, KW (corresponding author), Seoul Natl Univ, Bundang Hosp, Dept Neuropsychiat, Coll Med, 82,Gumi Ro 173 Beon Gil, Seongnam Si 13620, Gyeonggido, South Korea.
EM kwkimmd@snu.ac.kr
RI Lee, Yoon/ABA-8808-2020; Kim, Ju/E-5983-2012; Han, Ji/D-6825-2012; Kim,
   Tae/AAR-9213-2020; Lee, Dong/H-2427-2012; Kim, Ki Woong/D-5801-2012
OI Kim, Bong Jo/0000-0003-2419-7306; Kim, Ki Woong/0000-0002-1103-3858
FU Research of Korea Centers for Disease Control and Prevention
   [2019-ER6201-01]; Korean Health Technology R&D Project, Ministry of
   Health and Welfare, Republic of Korea [HI09C1379 [A092077]]
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship and/or publication of this article: This
   research was supported by a fund [Grant No. 2019-ER6201-01] by Research
   of Korea Centers for Disease Control and Prevention, and by a grant from
   the Korean Health Technology R&D Project, Ministry of Health and
   Welfare, Republic of Korea (grant no. HI09C1379 [A092077]).
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NR 50
TC 1
Z9 1
U1 0
U2 5
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0004-8674
EI 1440-1614
J9 AUST NZ J PSYCHIAT
JI Aust. N. Z. J. Psych.
PD AUG
PY 2022
VL 56
IS 8
BP 1017
EP 1024
AR 00048674211041937
DI 10.1177/00048674211041937
EA AUG 2021
PG 8
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 3D1FV
UT WOS:000686966800001
PM 34420415
DA 2025-06-11
ER

PT J
AU Anagnostis, P
   Paschou, SA
   Katsiki, N
   Krikidis, D
   Lambrinoudaki, I
   Goulis, DG
AF Anagnostis, Panagiotis
   Paschou, Stavroula A.
   Katsiki, Niki
   Krikidis, Dimitrios
   Lambrinoudaki, Irene
   Goulis, Dimitrios G.
TI Menopausal Hormone Therapy and Cardiovascular Risk: Where are We Now?
SO CURRENT VASCULAR PHARMACOLOGY
LA English
DT Review
DE Menopausal hormone therapy; menopause; postmenopausal women;
   cardiovascular risk; dyslipidaemia; diabetes
ID CORONARY-HEART-DISEASE; ESTROGEN PLUS PROGESTIN;
   HIGH-DENSITY-LIPOPROTEIN; POSTMENOPAUSAL WOMEN; METABOLIC SYNDROME;
   REPLACEMENT THERAPY; POSITION STATEMENT; HEMOSTATIC FACTORS; NATURAL
   MENOPAUSE; AMERICAN-COLLEGE
AB Transition to menopause is associated with an increase in cardiovascular disease (CVD) risk, mainly attributed to lipid and glucose metabolism dysregulation, as well as to body fat redistribution, leading to abdominal obesity. Indeed, epidemiological evidence suggests that both early menopause (EM, defined as age at menopause <45 years) and premature ovarian insufficiency (POI, defined as age at menopause <40 years) are associated with 1.5-2-fold increase in CVD risk. Menopausal hormone therapy (MHT) exerts a favorable effect on CVD risk factors (with subtle differences regarding oestrogen dose, route of administration, monotherapy or combination with progestogen and type of progestogen). Concerning CVD morbidity and mortality, most studies have shown a beneficial effect of MHT in women at early menopausal age (<10 years since the final menstrual period) or younger than 60 years. MHT is strongly recommended in women with EM and POI, as these women, if left untreated, are at risk of CVD, osteoporosis, dementia, depression and premature death. MHT has also a favorable benefit/risk profile in perimenopausal and early postmenopausal women, provided that the patient is not at a high CVD risk (as assessed by 10-year calculation tools). Transdermal oestrogens have a lower risk of thrombosis compared with oral regimens. Concerning progestogens, natural progesterone and dydrogesterone have a neutral effect on CVD risk factors. In any case, the decision for MHT should be individualized, tailored according to the symptoms, patient preference and the risk of CVD, thrombotic episodes and breast cancer.
C1 [Anagnostis, Panagiotis; Goulis, Dimitrios G.] Aristotle Univ Thessaloniki, Med Sch, Dept Obstet & Gynecol 1, Unit Reprod Endocrinol, Sarantaporou 10, Thessaloniki 54640, Greece.
   [Paschou, Stavroula A.] Natl & Kapodistrian Univ Athens, Aghia Sophia Hosp, Med Sch, Div Endocrinol & Diabet, Athens, Greece.
   [Katsiki, Niki] Aristotle Univ Thessaloniki, Med Sch, Hippokration Gen Hosp, Propedeut Dept Internal Med 2, Thessaloniki, Greece.
   [Krikidis, Dimitrios] Aristotle Univ Thessaloniki, Med Sch, Hippokration Gen Hosp, Cardiol Dept 2, Thessaloniki, Greece.
   [Lambrinoudaki, Irene] Natl & Kapodistrian Univ Athens, Dept Obstet & Gynecol 2, Athens, Greece.
C3 Aristotle University of Thessaloniki; National & Kapodistrian University
   of Athens; Aristotle University of Thessaloniki; Aristotle University of
   Thessaloniki; National & Kapodistrian University of Athens
RP Anagnostis, P (corresponding author), Aristotle Univ Thessaloniki, Med Sch, Dept Obstet & Gynecol 1, Unit Reprod Endocrinol, Sarantaporou 10, Thessaloniki 54640, Greece.
EM anagnwstis.pan@yahoo.gr
RI Goulis, Dimitrios/AAG-4589-2020; Anagnostis, Panagiotis/S-4803-2019;
   KATSIKI, NIKI/ADE-7999-2022
OI KATSIKI, NIKI/0000-0003-0894-2644; Lambrinoudaki,
   Irene/0000-0003-1488-2668
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NR 88
TC 45
Z9 51
U1 2
U2 24
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1570-1611
EI 1875-6212
J9 CURR VASC PHARMACOL
JI Current Vascular Pharmacology
PY 2019
VL 17
IS 6
BP 564
EP 572
DI 10.2174/1570161116666180709095348
PG 9
WC Pharmacology & Pharmacy; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Cardiovascular System & Cardiology
GA JB4WR
UT WOS:000488562600005
PM 29984659
DA 2025-06-11
ER

PT J
AU Salihu, HM
   Bonnema, S
   Alio, AP
AF Salihu, Harnisu M.
   Bonnema, Sarah
   Alio, Amina P.
TI Obesity: What is an elderly population growing into?
SO MATURITAS
LA English
DT Review
DE Obesity; Elderly; Morbidity; Mortality
ID BODY-MASS INDEX; AGED 50 YEARS; RISK-FACTORS; CARDIOVASCULAR-DISEASE;
   WAIST CIRCUMFERENCE; PROSPECTIVE COHORT; ABDOMINAL OBESITY;
   UNITED-STATES; OLDER-PEOPLE; OVERWEIGHT
AB Objectives: Obesity is currently a major public health concern; however, there is little data available on the prevalence and impact of obesity within the elderly population. This review examines the prevalence and health effects of obesity among individuals aged >= 50.
   Methods: PubMed (1996-2008) and PsychInfo (2002-2008) search engines were used to retrieve qualified peer-reviewed articles focusing on obesity or a health condition correlated with obesity using BMI or other weight index as a defining variable; and studies limited to the elderly (age 60+) or pre-elderly (50+).
   Results: Worldwide, the elderly Population is increasingly becoming obese regardless of socio-economic status. Among elderly persons, obesity increases the risks for a variety of morbidity conditions including cancers, diabetes, hypertension, stroke, heart disease, metabolic syndrome, obstructive sleep apnea syndrome, osteoarthritis, depression, disability, and lower scores on quality of life measures. In some reports, obesity has been linked to Alzheimer's disease and other forms of cognitive decline. Obesity significantly increases healthcare costs and nursing homes are currently ill equipped to address the needs of the rising number of obese residents.
   Conclusions: Obesity is increasing in the elderly Population worldwide and is expected to continue to rise. Obesity is associated with disease and disability in addition to escalating healthcare costs, and hospitals and nursing homes are ill equipped to serve the obese elderly. It is imperative that research efforts and funding be devoted to studying the effects and the reduction of obesity in the elderly population. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
C1 [Salihu, Harnisu M.] Univ S Florida, Lawton & Rhea Chiles Ctr Healthy Mothers & Babies, Ctr Res & Evaluat, Dept Obstet & Gynecol, Tampa, FL 33613 USA.
   [Salihu, Harnisu M.] Univ S Florida, Dept Epidemiol & Biostat, Tampa, FL 33613 USA.
   [Bonnema, Sarah; Alio, Amina P.] Univ S Florida, Dept Community & Family Med, Tampa, FL 33613 USA.
C3 State University System of Florida; University of South Florida; State
   University System of Florida; University of South Florida; State
   University System of Florida; University of South Florida
RP Salihu, HM (corresponding author), Univ S Florida, Lawton & Rhea Chiles Ctr Healthy Mothers & Babies, Ctr Res & Evaluat, Dept Obstet & Gynecol, 3111 E Fletcher Ave, Tampa, FL 33613 USA.
EM hamisu.salihu@gmail.com
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NR 69
TC 66
Z9 75
U1 1
U2 38
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0378-5122
EI 1873-4111
J9 MATURITAS
JI Maturitas
PD MAY 20
PY 2009
VL 63
IS 1
BP 7
EP 12
DI 10.1016/j.maturitas.2009.02.010
PG 6
WC Geriatrics & Gerontology; Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Obstetrics & Gynecology
GA 463VY
UT WOS:000267462300003
PM 19328637
OA Bronze
DA 2025-06-11
ER

PT J
AU Elmi, S
   Sahu, G
   Malavade, K
   Jacob, T
AF Elmi, Sarah
   Sahu, Geetanjali
   Malavade, Kishor
   Jacob, Theresa
TI Role of tissue plasminogen activator and plasminogen activator inhibitor
   as potential biomarkers in psychosis
SO ASIAN JOURNAL OF PSYCHIATRY
LA English
DT Article
DE Tissue plasminogen activator; Plasminogen activator inhibitor-1;
   Psychosis; Ethnicity; Schizophrenia; Schizoaffective
ID ATYPICAL ANTIPSYCHOTICS; INFLAMMATION MARKERS; METABOLIC SYNDROME;
   SCHIZOPHRENIA; HOMOCYSTEINE; 1ST-EPISODE; DEPRESSION; INSULIN;
   COAGULATION; IMPAIRMENT
AB The identification of biological markers for psychosis has an impact on its diagnosis, prognosis, and likelihood of treatment response. Tissue plasminogen activator (tPA) is involved in important functions such as synaptic plasticity, long-term potentiation and neurogenesis. Plasminogen activator inhibitor (PAI-1) is the most important inhibitor of tPA. Preliminary studies have shown that schizophrenia patients have lower tPA and higher PAI-1 levels than the general population. The association of tPA and PAI-1 abnormalities with psychotic spectrum disorders, however, remains elusive. Our primary objective was to assess the plasma levels of tPA and PAI-1 in patients experiencing acute psychotic episodes as compared to those in healthy controls. In this prospective case-control study, we collected peripheral blood samples from psychiatric inpatients and healthy age, gender and race-matched subjects and determined plasma levels of tPA and PAI-1 by enzyme-linked immune-absorbent assays. Plasma levels of PAI-1 in patients with schizoaffective disorder were significantly lower as compared to those in control subjects (P = 0.03). tPA was lower in cases as compared to controls although it did not reach statistical significance. Asian patients and controls had lower PAI-1 levels. Further, Asian patients with schizoaffective disorder had significantly lower PAI-1 level compared to Asian patients with schizophrenia. Our results indicate that patients with schizoaffective disorder have lower PAI-1 levels than those with schizophrenia, affective psychosis, and healthy controls. Further studies are warranted to explore the potential of PAI-1 as a biomarker for diagnosing schizoaffective disorder.
C1 [Elmi, Sarah; Sahu, Geetanjali; Malavade, Kishor; Jacob, Theresa] Maimonides Hosp, Dept Psychiat, 4802 Tenth Ave, Brooklyn, NY 11219 USA.
C3 Maimonides Medical Center
RP Jacob, T (corresponding author), Maimonides Hosp, Dept Psychiat, 4802 Tenth Ave, Brooklyn, NY 11219 USA.; Jacob, T (corresponding author), Maimonides Hosp, Clin & Translat Res Labs, 4802 Tenth Ave, Brooklyn, NY 11219 USA.
EM tjacob@maimonidesmed.org
FU Maimonides Research and Development Foundation [49840]
FX This work was supported by a grant from Maimonides Research and
   Development Foundation (grant number 49840).
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NR 44
TC 12
Z9 12
U1 0
U2 3
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1876-2018
EI 1876-2026
J9 ASIAN J PSYCHIATR
JI Asian J. Psychiatr.
PD JUN
PY 2019
VL 43
BP 105
EP 110
DI 10.1016/j.ajp.2019.05.021
PG 6
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychiatry
GA IS5XW
UT WOS:000482227500027
PM 31125952
DA 2025-06-11
ER

PT J
AU Lee, I
   Bang, KS
   Moon, H
   Kim, J
AF Lee, Insook
   Bang, Kyung-Sook
   Moon, Hyojeong
   Kim, Jieun
TI Risk Factors for Obesity Among Children Aged 24 to 80 months in Korea: A
   Decision Tree Analysis
SO JOURNAL OF PEDIATRIC NURSING-NURSING CARE OF CHILDREN & FAMILIES
LA English
DT Article
DE Child, Preschool; Pediatric obesity; Community health nursing; Decision
   trees; Family characteristics
ID CHILDHOOD OBESITY; METABOLIC SYNDROME; OVERWEIGHT; ADOLESCENTS;
   ADIPOSITY; HEALTH
AB Purpose: The purpose of this study was to examine the multiple intergenerational risk factors of obesity among children aged 24 to 80 months using national cohort data.
   Design and methods: This is a retrospective longitudinal cohort study using the Korean National Health Insurance (KNHI) database, and the number of study participants was 1,001,775 families. Social-Economic Status (SES), parental and child-related factors were examined. Descriptive statistics and Chi-squared Automatic Interaction Detection (CHAID) for a decision tree analysis were conducted.
   Results: The prevalence of obesity was 6.57%, and that of overweight was 11.31% among the entire study population. The 17 groups with a prevalence of childhood obesity higher than the mean prevalence rate were classified as high-risk groups for childhood obesity; there were 6 groups with a prevalence of childhood obesity twice as high as the mean prevalence rate from this study. The best predictors were as follows: mothers being obese prior to conception, fathers being obese, non- medical aid beneficiaries, and mothers with hypertension during gestation.
   Conclusions: The best predictors of children obesity were parental obesity history and SES. Other parental predictors of outcomes were gestational hypertension and diabetes, older pregnancy, drinking during gestation, and depression after delivery. Child-related outcome predictors were noncompliance with exclusive breastfeeding, a sugar-sweetened beverage intake >= 200 ml per day, and irregular breakfast consumption.
   Practice implications: These findings could help community health nurses assess high-risk groups for early childhood obesity and develop or provide effective interventions in the early stages of life. (C) 2019 Elsevier Inc. All rights reserved.
C1 [Lee, Insook; Bang, Kyung-Sook] Seoul Natl Univ, Coll Nursing, Res Inst Nursing Sci, Seoul, South Korea.
   [Moon, Hyojeong] Seoul Natl Univ, Coll Nursing, Seoul, South Korea.
   [Kim, Jieun] Chung Cheong Univ, Coll Nursing, Cheongju, Chungcheongbuk, South Korea.
C3 Seoul National University (SNU); Seoul National University (SNU)
RP Kim, J (corresponding author), Chung Cheong Univ, Coll Nursing, Cheongju, Chungcheongbuk, South Korea.
EM lisook@snu.ac.kr; ksbang@snu.ac.kr; hyojmoon@snu.ac.kr;
   jieunk0329@gmail.com
RI Bang, Kyung-Sook/D-5780-2012
OI Bang, Kyung-Sook/0000-0001-9902-9716
FU National Health Insurance Service [810-20150003]
FX Data were obtained from the National Health Insurance Service [grant
   numbers; 810-20150003].
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NR 37
TC 13
Z9 13
U1 1
U2 20
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0882-5963
J9 J PEDIATR NURS
JI J. Pediatr. Nurs.
PD MAY-JUN
PY 2019
VL 46
BP E15
EP E23
DI 10.1016/j.pedn.2019.02.004
PG 9
WC Nursing; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Pediatrics
GA HX4SM
UT WOS:000467390600004
PM 30773305
DA 2025-06-11
ER

PT J
AU Sato, F
   Kohsaka, A
   Takahashi, K
   Otao, S
   Kitada, Y
   Iwasaki, Y
   Muragaki, Y
AF Sato, Fuyuki
   Kohsaka, Akira
   Takahashi, Kana
   Otao, Saki
   Kitada, Yusuke
   Iwasaki, Yoshiyuki
   Muragaki, Yasuteru
TI Smad3 and Bmal1 regulate p21 and S100A4
   expression in myocardial stromal fibroblasts via TNF-α
SO HISTOCHEMISTRY AND CELL BIOLOGY
LA English
DT Article
DE Clock gene; Smad3; Bmal1; Stromal fibroblasts; Old myocardial infarction
ID CLOCK MUTANT MICE; SUPRACHIASMATIC NUCLEUS; CIRCADIAN EXPRESSION;
   PERIPHERAL-TISSUES; GENE-EXPRESSION; MESSENGER-RNA; STEM-CELL; PLAYS;
   INFARCTION; FIBROSIS
AB Bmal1, a clock gene, is associated with depression, hypertrophy, metabolic syndrome and diabetes. Smad3, which is involved in the TGF-beta signaling pathway, plays an important role in the regulation of tumor progression, fibrosis, obesity and diabetes. Our previous report showed that Smad3 has circadian expression in mouse livers. In the current study, we focused on the heart, especially on the myocardial stromal fibroblasts because the roles of Bmal1 and Smad3 in this tissue are poorly understood. Bmal1 and Smad3 have circadian expression in mouse hearts, and their circadian expression patterns were similar. Bmal1 expression decreased in the hearts of whole-body Smad3 knockout mice, whereas Smad3 expression had little effect on heart-specific Bmal1 knockout mice. Both Smad3 knockout and heart-specific Bmal1 knockout mice showed increases in p21, S100A4, CD206 and TNF-alpha expression in the myocardial stromal fibroblasts and macrophage compared to control mice. We also examined Smad3, Bmal1 and Dec1 expression in human tissue from old myocardial infarctions. Expression of Smad3, Bmal1 and Dec1 decreased in the stromal fibroblasts of tissue from old myocardial infarctions compared to control cases. On the other hand, p21, S100A4 and TNF-alpha increased in the stromal fibroblasts of tissue from old myocardial infarctions. Furthermore, expression of Smad3, Bmal1 and Dec1 decreased in TNF-alpha treated-NIH3T3 cells but expression of p21 and S100A4 increased. This new evidence suggests that Smad3 and Bmal1 regulate p21 and S100A4 expression in myocardial stromal fibroblasts through TNF-alpha.
C1 [Sato, Fuyuki; Takahashi, Kana; Otao, Saki; Kitada, Yusuke; Iwasaki, Yoshiyuki; Muragaki, Yasuteru] Wakayama Med Univ, Dept Pathol, Sch Med, 811-1 Kimiidera, Wakayama 6418509, Japan.
   [Kohsaka, Akira] Wakayama Med Univ, Dept Physiol, Sch Med, Wakayama, Japan.
C3 Wakayama Medical University; Wakayama Medical University
RP Sato, F (corresponding author), Wakayama Med Univ, Dept Pathol, Sch Med, 811-1 Kimiidera, Wakayama 6418509, Japan.
EM fsatoDEC1DEC2@yahoo.co.jp
OI Sato, Fuyuki/0000-0002-4435-2118
FU Japan Society for the Promotion of Science [16K09624, 15K08430];
   Grants-in-Aid for Scientific Research [16K09624, 15K08430] Funding
   Source: KAKEN
FX This work was supported by the Japan Society for the Promotion of
   Science Grants-in-Aid for Scientific Research (KAKENHI; 16K09624 of FS
   and 15K08430 of YM).
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NR 31
TC 27
Z9 32
U1 2
U2 11
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0948-6143
EI 1432-119X
J9 HISTOCHEM CELL BIOL
JI Histochem. Cell Biol.
PD DEC
PY 2017
VL 148
IS 6
BP 617
EP 624
DI 10.1007/s00418-017-1597-x
PG 8
WC Cell Biology; Microscopy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Microscopy
GA FN6RI
UT WOS:000416143000005
PM 28721450
DA 2025-06-11
ER

PT J
AU Melo, MCA
   Daher, ED
   Albuquerque, SGC
   de Bruin, VMS
AF Aguiar Melo, Matias Carvalho
   de Francesco Daher, Elizabeth
   Castor Albuquerque, Saulo Giovanni
   Sales de Bruin, Veralice Meireles
TI Exercise in bipolar patients: A systematic review
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Review
DE Physical activity; Sedentary lifestyle; Exercise; Bipolar disorder;
   Mania
ID MEASURED PHYSICAL-ACTIVITY; LIFE-STYLE FACTORS; METABOLIC SYNDROME;
   DEPRESSIVE SYMPTOMS; HEALTHY CONTROLS; ITALIAN PATIENTS; MENTAL-ILLNESS;
   MOOD SYMPTOMS; DISORDER; PEOPLE
AB Background: Sedentary lifestyle is frequent in psychiatric disorders, however the directions of this association and benefits of physical activity are unclear. This is a systematic review about exercise in patients with bipolar disorder.
   Methods: We performed a systematic literature search of studies published in English (1995 Jan to 2016 Jan) in PubMed, and Cochrane Library combining the medical terms 'physical activity' or 'sedentary' or 'physical exercise' with 'bipolar disorder' or 'mania' or 'bipolar depression'.
   Results: Thirty-one studies were selected and included 15,587 patients with bipolar disorder. Sedentary lifestyle varied from 40% to 64.9%. Physical activity was associated with less depressive symptoms, better quality of life and increased functioning. Some evidence indicates a relationship between vigorous exercises and mania. Three prospective cohorts were reported; and no prospective randomized controlled trial was identified. Three studies focused on biomarkers in bipolar patients; and one reported the relationship between exercise and sleep in this group. Two assessed physical exercise in adolescents.
   Limitations: (1) Differences between studies preventing a unified analysis; (2) most studies were cross-sectional; (3) motivation for exercising is a selection bias in most studies; (4) no intervention study assessing only physical exercise; (5) lack of studies comparing exercise across mood states.
   Conclusion: Generally, exercise was associated with improved health measures including depressive symptoms, functioning and quality of life. Evidence was insufficient to establish a cause-effect relationship between mood and physical exercise. Future research including randomized trials is needed to clarify the role of physical activity in bipolar patients. (C) 2016 Elsevier B.V. All rights reserved.
C1 [Aguiar Melo, Matias Carvalho; de Francesco Daher, Elizabeth; Sales de Bruin, Veralice Meireles] Univ Fed Ceara, Dept Med Sci, Ave Sargento Herminio,880 Quadra A Bloco 5 Ap 201, BR-60326348 Fortaleza, CE, Brazil.
   [Castor Albuquerque, Saulo Giovanni] Hosp Saude Mental Prof Frota Pinto, Brasilia, DF, Brazil.
C3 Universidade Federal do Ceara
RP Melo, MCA (corresponding author), Univ Fed Ceara, Dept Med Sci, Ave Sargento Herminio,880 Quadra A Bloco 5 Ap 201, BR-60326348 Fortaleza, CE, Brazil.
EM matcarv01@yahoo.com.br
RI Melo, Matias/Z-6094-2019; Daher, Elizabeth/G-2210-2012
OI Daher, Elizabeth/0000-0003-4189-1738
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NR 77
TC 79
Z9 88
U1 1
U2 67
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD JUL 1
PY 2016
VL 198
BP 32
EP 38
DI 10.1016/j.jad.2016.03.004
PG 7
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA DK6TK
UT WOS:000375058100004
PM 26998794
OA Green Published
DA 2025-06-11
ER

PT J
AU Hishikawa, N
   Fukui, Y
   Nakano, Y
   Morihara, R
   Takemoto, M
   Sato, K
   Yamashita, T
   Ohta, Y
   Abe, K
AF Hishikawa, N.
   Fukui, Y.
   Nakano, Y.
   Morihara, R.
   Takemoto, M.
   Sato, K.
   Yamashita, T.
   Ohta, Y.
   Abe, K.
TI Factors related to continuous and discontinuous attendance at memory
   clinics
SO EUROPEAN JOURNAL OF NEUROLOGY
LA English
DT Article
DE activities of daily living; behavioral and psychological symptoms of
   dementia; cognitive function; dementia; discontinuous attendance; memory
   clinic
ID ALZHEIMERS-DISEASE PATIENTS; NURSING-HOME PLACEMENT; VASCULAR
   RISK-FACTORS; METABOLIC SYNDROME; DEMENTIA
AB Background and purpose: Few studies have examined why some patients with dementia stop attending medical consultations. We conducted a retrospective study to investigate factors associated with discontinuous clinic attendance.
   Methods: Participants were 988 patients with dementia from university hospital (UH) clinics and affiliated local hospital (LH) clinics. We compared continuous and discontinuous attenders on cognitive and affective functions and activities of daily living (ADL), and also compared UH and LH patients (UH: continuous, n = 176; discontinuous, n = 207; LH: continuous, n = 418; discontinuous, n = 187).
   Results: The total annual rate of discontinuation was 8.0%, and the mean period of attendance before discontinuation was 2.2 2.4 years (UH, 2.8 +/- 3.0; LH, 1.5 +/- 1.3, P < 0.01). Scores for the Mini-Mental State Examination, Hasegawa Dementia Scale - Revised, Geriatric Depression Scale, apathy scale, Abe's behavioral and psychological symptoms of dementia (BPSD) score, and ADL were significantly worse in the discontinuous group than the continuous group for both UH and LH patients (P < 0.01). The best predictor of discontinuation was ADL decline (UH and LH) and Abe's BPSD score (UH). The most common reason for discontinuation was returning to the family doctor (39.1% for UH), and cessation of hospital attendance at their own discretion (35.3% for LH).
   Conclusions: We identified the main reasons for discontinuation of attendance as returning to the family doctor and cessation of hospital attendance at their own discretion. The best predictors of discontinuation were ADL decline and worsening BPSD. There were significant differences in discontinuation between UH and LH patients with dementia.
C1 [Hishikawa, N.; Fukui, Y.; Nakano, Y.; Morihara, R.; Takemoto, M.; Sato, K.; Yamashita, T.; Ohta, Y.; Abe, K.] Okayama Univ, Dept Neurol, Grad Sch Med Dent & Pharmaceut Sci, Okayama, Japan.
C3 Okayama University
RP Abe, K (corresponding author), Okayama Univ, Dept Neurol, Grad Sch Med Dent & Pharmaceut Sci, Kita Ku, 2-5-1 Shikatacho, Okayama 7008558, Japan.
EM nozomi-hishikawa@okayama-u.ac.jp
OI Yamashita, Toru/0000-0003-3634-5679
FU Japanese Ministry of Health, Labour and Welfare;  [2529320216]; 
   [24591263];  [24659651]
FX This work was partly supported by a Grant-in-Aid for Scientific Research
   [(B) 2529320216, (C) 24591263 and Challenging Research 24659651] and by
   Grants-in-Aid from the Research Committees (H. Mizusawa, K. Nakashima,
   M. Nishizawa, H. Sasaki and M. Aoki) from the Japanese Ministry of
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NR 22
TC 4
Z9 4
U1 0
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1351-5101
EI 1468-1331
J9 EUR J NEUROL
JI Eur. J. Neurol.
PD MAY
PY 2017
VL 24
IS 5
BP 673
EP 679
DI 10.1111/ene.13268
PG 7
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA ES7BL
UT WOS:000399704400006
PM 28251765
DA 2025-06-11
ER

PT J
AU Coelho, FM
   Pereira, DS
   Lustosa, LP
   Silva, JP
   Dias, JMD
   Dias, RCD
   Queiroz, BZ
   Teixeira, AL
   Teixeira, MM
   Pereira, LSM
AF Coelho, F. M.
   Pereira, D. S.
   Lustosa, L. P.
   Silva, J. P.
   Dias, J. M. D.
   Dias, R. C. D.
   Queiroz, B. Z.
   Teixeira, A. L.
   Teixeira, M. M.
   Pereira, L. S. M.
TI Physical therapy intervention (PTI) increases plasma brain-derived
   neurotrophic factor (BDNF) levels in non-frail and pre-frail elderly
   women
SO ARCHIVES OF GERONTOLOGY AND GERIATRICS
LA English
DT Article
DE Physical therapy intervention; Brain-derived neurotrophic factor;
   Frailty
ID METABOLIC SYNDROME; EXERCISE; DEPRESSION; SERUM; INFLAMMATION;
   PLASTICITY; STRENGTH; DISEASES; MUSCLE; RISK
AB Biomarkers are important factors in the identification of the frail elderly (higher risk of developing disease) and in assessing the impact of PTI. On the other hand, BDNF has been related to neuroprotection in a series of central nervous system diseases in older age. The levels of BDNF in groups of elderly women classified according to Fried phenotype (non-frail and pre-frail) were compared. We assessed the impact of a PTI on BDNF levels. A convenience sample of 48 elderly women was randomly selected. The PTI group was composed by 20 elderly women selected from this group. Plasma neurotrophic factors, such as BDNF, glial-derived neutrophic factor (GDNF), and nerve growth factor (NGF) were measured by enzyme-linked immunosorbent assay (ELISA). Timed-up-and-go (TUG) test, hand-grip and work/body weight were evaluated before and after the intervention. Plasma concentrations of BDNF were significantly higher in non-frail in comparison to pre-frail elderly women. After the PTI, higher levels of BDNF were found in elderly women (before 351 +/- 68 pg/ml and after 593 +/- 79 pg/ml; p < 0.001). Both groups had an increase in BDNF levels after the PTI. The low levels of BDNF in pre-frail elderly women suggest that this neurotrophic factor may be a key pathophysiological mediator in the syndrome of frailty. The fact that PTI increased BDNF levels in both groups suggests that it may be possible to modify this phenotype. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
C1 [Coelho, F. M.; Pereira, D. S.; Lustosa, L. P.; Silva, J. P.; Dias, J. M. D.; Dias, R. C. D.; Queiroz, B. Z.; Pereira, L. S. M.] Univ Fed Minas Gerais, Escola Educ Fis Fisioterapia & Terapia Ocupac, Dept Fisioterapia, BR-31270901 Belo Horizonte, MG, Brazil.
   [Teixeira, A. L.] Fac Med, Dept Bioquim & Imunol, BR-30130100 Belo Horizonte, MG, Brazil.
   [Teixeira, M. M.] Univ Fed Minas Gerais, Inst Ciencias Biol, BR-31270901 Belo Horizonte, MG, Brazil.
C3 Universidade Federal de Minas Gerais; Universidade Federal de Minas
   Gerais
RP Coelho, FM (corresponding author), Univ Fed Minas Gerais, Escola Educ Fis Fisioterapia & Terapia Ocupac, Dept Fisioterapia, Ave Antonio Carlos,6627 Pampulha, BR-31270901 Belo Horizonte, MG, Brazil.
EM fematoscoelho@gmail.com
RI Dias, João/L-6496-2013; PEREIRA, DANIELE/AAB-9374-2020; PEREIRA DA
   SILVA, JUSCELIO/AAA-8414-2019; Lustosa, Lygia/Z-1151-2018; Teixeira,
   Antonio/N-3315-2014; Teixeira, Mauro/A-4587-2008
OI Silva, Juscelio/0000-0002-0382-4377; Teixeira, Antonio
   Lucio/0000-0002-9621-5422; Teixeira, Mauro/0000-0002-6944-3008
FU Conselho Nacional de Desenvolvimento Cientifico e Tecnologico, CNPq;
   Fundacao de Amparo a Pesquisa de Minas Gerais, FAPEMIG
FX The authors acknowledge financial support from Conselho Nacional de
   Desenvolvimento Cientifico e Tecnologico, CNPq and Fundacao de Amparo a
   Pesquisa de Minas Gerais, FAPEMIG.
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NR 40
TC 100
Z9 106
U1 0
U2 24
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0167-4943
EI 1872-6976
J9 ARCH GERONTOL GERIAT
JI Arch. Gerontol. Geriatr.
PD MAY-JUN
PY 2012
VL 54
IS 3
BP 415
EP 420
DI 10.1016/j.archger.2011.05.014
PG 6
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA 928DB
UT WOS:000302959400033
PM 21684022
DA 2025-06-11
ER

PT J
AU Lesiewska, N
   Kaminska, A
   Junik, R
   Michalewicz, M
   Myszkowski, B
   Borkowska, A
   Bielinski, M
AF Lesiewska, Natalia
   Kaminska, Anna
   Junik, Roman
   Michalewicz, Magdalena
   Myszkowski, Bartlomiej
   Borkowska, Alina
   Bielinski, Maciej
TI Affective Temperament and Glycemic Control-The Psychological Aspect of
   Obesity and Diabetes Mellitus
SO DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
LA English
DT Article
DE affective temperament; TEMPS-A; obesity; diabetes mellitus; glycemic
   control
ID MAJOR DEPRESSIVE DISORDER; METABOLIC SYNDROME; BIPOLAR DISORDER;
   TEMPS-A; RISK; SCHIZOPHRENIA; MEMPHIS; PEOPLE; PISA; PREVALENCE
AB Purpose: Affective temperament shows innate predisposition to affective disorders and has been studied in patients with type 2 diabetes mellitus (T2DM) and obesity. Studies describing connections between depressive disorders, obesity and T2DM, show a bidirectional way in which these disorders affect each other. Given that obesity, depression, and T2DM are still growing health problems of our times, the improvement of therapeutic strategies is required. The aim of our study was to evaluate affective temperament in obese individuals with T2DM and pre-diabetes and to investigate the correlations between affective temperaments and glycemic control. Materials and Methods: The study enrolled 185 obese individuals (146 females; 39 males) who were diagnosed with pre-diabetes, diabetes or without any carbohydrate disorder. For affective temperament evaluation, Temperament Evaluation of Memphis, Pisa, Paris and San Diego Autoquestionnaire (TEMPS-A) was utilized; for glycemic control, the assessment of hemoglobin A1c (HbA1c) was performed. Results: We did not observe any significant differences of affective temperament between studied groups. In the group of patients with diabetes, depressive, cyclothymic and anxious temperaments positively correlated with HbA1c values indicating worse glycemic control. Inversly, hyperthymic dimension showed negative correlation with HbA1c values. Conclusion: Affective temperaments may affect glycemic control in obese individuals with carbohydrate disorders. Individuals with stronger expression of cyclothymic, depressive and anxious temperaments may need more medical aid for better self-management. Hence, TEMPS-A is an easy and useful tool which may significantly improve the compliance in obese patients with carbohydrate disorders.
C1 [Lesiewska, Natalia; Borkowska, Alina; Bielinski, Maciej] Nicolaus Copernicus Univ Torun, Coll Med Bydgoszcz, Chair & Dept Clin Neuropsychol, Bydgoszcz, Poland.
   [Kaminska, Anna; Junik, Roman] Nicolaus Copernicus Univ Torun, Coll Med Bydgoszcz, Dept Endocrinol & Diabetol, Bydgoszcz, Poland.
   [Michalewicz, Magdalena] Policlin Bydgoszcz, Mil Clin Hosp 10, Dept Pulmonol Allergol & Pulmonol Oncol, Bydgoszcz, Poland.
   [Myszkowski, Bartlomiej] Nicolaus Copernicus Univ Torun, Coll Med Bydgoszcz, Dept Obstet Womens Dis & Oncol Gynecol, Bydgoszcz, Poland.
C3 Nicolaus Copernicus University; Ludwik Rydygier Collegium Medicum;
   Nicolaus Copernicus University; Ludwik Rydygier Collegium Medicum;
   Nicolaus Copernicus University; Ludwik Rydygier Collegium Medicum
RP Lesiewska, N (corresponding author), Nicolaus Copernicus Univ Torun, Coll Med Bydgoszcz, Chair & Dept Clin Neuropsychol, Bydgoszcz, Poland.
EM n.lesiewska@gmail.com
RI Borkowska, Alina/G-8816-2014; Bielinski, Maciej/B-2220-2017; Kamińska,
   Anna/F-3696-2014
OI Borkowska, Alina/0000-0001-7305-0242
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NR 74
TC 6
Z9 6
U1 0
U2 9
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-7007
J9 DIABET METAB SYND OB
JI Diabetes Metab. Syndr. Obes.
PY 2021
VL 14
BP 4981
EP 4991
DI 10.2147/DMSO.S342185
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism
GA YC6YL
UT WOS:000739834400001
PM 35002270
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Bouloukaki, I
   Tsiligianni, I
   Mermigkis, C
   Bonsignore, MR
   Markakis, M
   Pataka, A
   Steiropoulos, P
   Ermidou, C
   Alexaki, I
   Tzanakis, N
   Schiza, S
AF Bouloukaki, Izolde
   Tsiligianni, Ioanna
   Mermigkis, Charalampos
   Bonsignore, Marisa R.
   Markakis, Manolis
   Pataka, Athanasia
   Steiropoulos, Paschalis
   Ermidou, Christina
   Alexaki, Ioanna
   Tzanakis, Nikolaos
   Schiza, Sophia
TI Vitamin D deficiency in patients evaluated for obstructive sleep apnea:
   is it associated with disease severity?
SO SLEEP AND BREATHING
LA English
DT Article
DE Vitamin D; Obstructive sleep apnea; Polysomnography; Vitamin D
   deficiency
ID BECK DEPRESSION INVENTORY; POSITIVE AIRWAY PRESSURE; 25-HYDROXYVITAMIN
   D; METABOLIC SYNDROME; VALIDITY; COHORT
AB Purpose The aim of the present study was to assess vitamin D levels in a large cohort of OSA patients and to investigate possible correlations with clinical and polysomnographic parameters. Methods In this cross-sectional study, 685 consecutive patients underwent type 1 polysomnography (PSG) for OSA diagnosis. They were grouped according to apnea-hypopnea index (AHI) as mild, moderate, and severe. Patients with AHI < 5 served as controls. Demographic, PSG data, and serum levels of vitamin D were measured and compared between groups. Results OSA was diagnosed in 617 of the patients (90%). Of those, 94 (15%) had mild OSA, 150 (24%) moderate OSA, and 373 (61%) severe OSA. The risk of vitamin D deficiency (< 20 ng/mL) was observed in 38% of the cohort. OSA patients had lower vitamin D levels compared to controls (23 ng/mL vs 26 ng/mL,p = 0.006). The lowest levels of vitamin D [mean 21] (p < 0.001 among all groups) and the higher prevalence for vitamin D deficiency (45%) were observed in severe OSA patients. After multiparametric adjustments for age, gender, obesity, and comorbidities, severe OSA showed significant independent associations with the risk of vitamin D deficiency [OR (95% CI) 2.002 (1.049-3.819),p = 0.035]. Conclusions A large proportion of patients referred for OSA evaluation had vitamin D deficiency, which was independently associated with severe OSA. However, further research is needed in order to determine the role of vitamin D in OSA patients.
C1 [Bouloukaki, Izolde; Mermigkis, Charalampos; Ermidou, Christina; Alexaki, Ioanna; Tzanakis, Nikolaos; Schiza, Sophia] Univ Crete, Sleep Disorders Ctr, Sch Med, Dept Resp Med, Voutes Campus, GR-71003 Iraklion, Crete, Greece.
   [Bouloukaki, Izolde; Markakis, Manolis] Primary Care Hlth Ctr Kastelli, Iraklion, Crete, Greece.
   [Tsiligianni, Ioanna] Univ Crete, Fac Med, Dept Social Med, Iraklion, Greece.
   [Bonsignore, Marisa R.] Univ Palenno, PROMISE, Palermo, Italy.
   [Pataka, Athanasia] Aristotle Univ Thessaloniki, Med Sch, G Papanikolaou Hosp, Dept Resp Med,Resp Failure Unit, Thessaloniki, Greece.
   [Steiropoulos, Paschalis] Democritus Univ Thrace, Dept Pneumonol, Sleep Unit, Alexandroupolis, Greece.
C3 University of Crete; University of Crete; Aristotle University of
   Thessaloniki; George Papanikolaou General Hospital of Thessaloniki;
   Democritus University of Thrace
RP Bouloukaki, I (corresponding author), Univ Crete, Sleep Disorders Ctr, Sch Med, Dept Resp Med, Voutes Campus, GR-71003 Iraklion, Crete, Greece.; Bouloukaki, I (corresponding author), Primary Care Hlth Ctr Kastelli, Iraklion, Crete, Greece.
EM izolthi@gmail.com
RI Bonsignore, Maria/U-6440-2017; Tsiligianni, Ioanna/IUN-4739-2023;
   Steiropoulos, Paschalis/AAH-6905-2021; Bouloukaki, Izolde/HPD-4015-2023
OI Tsiligianni, Ioanna/0000-0001-7922-7491
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NR 46
TC 16
Z9 16
U1 0
U2 5
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1520-9512
EI 1522-1709
J9 SLEEP BREATH
JI Sleep Breath.
PD JUN
PY 2021
VL 25
IS 2
BP 1109
EP 1117
DI 10.1007/s11325-020-02142-w
EA JUL 2020
PG 9
WC Clinical Neurology; Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Respiratory System
GA SQ7ZC
UT WOS:000546893300001
PM 32648186
DA 2025-06-11
ER

PT J
AU Kilicaslan, EE
   Karakilic, M
   Erol, A
AF Kilicaslan, Esin Evren
   Karakilic, Merve
   Erol, Almila
TI The Relationship between 10 Years Risk of Cardiovascular Disease and
   Schizophrenia Symptoms: Preliminary Results
SO PSYCHIATRY INVESTIGATION
LA English
DT Article
DE Schizophrenia; Cardiovascular risk; Framingham risk score; Schizophrenia
   symptoms; Antipsychotic treatment
ID CORONARY-HEART-DISEASE; BODY-MASS INDEX; METABOLIC SYNDROME;
   ANTIPSYCHOTIC TREATMENT; MEDICAL COMORBIDITY; SPECTRUM PATIENTS; EXCESS
   MORTALITY; PEOPLE; SMOKING; PREVALENCE
AB Objective Previous research shows that patients with schizophrenia have increased cardiovascular disease risk than general population. Increased cardiovascular risk in schizophrenia patients have been associated with many reasons such as antipsychotic drugs, genetic predisposition, andlifestyle. In this study, We aimed to investigate the relationship between the risk of heart disease and schizophrenia symptomatology.
   Methods The 10-year cardiovascular risk was assessed by the Framingham Risk Score (FRS) in 103 patients with schizophrenia and in 39 healthy controls. Sociodemographic characteristics, age at schizophrenia onset, duration of illness, number of hospitalizations, the course of the disease and antipsychotic medications were recorded. Patients' symptoms were evaluated via The Scale for the Assessment of Negative Symptoms (SANS), The Scale for the Assessment of Positive Symptoms (SAPS), and Calgary Depression Scale for Schizophrenia (CDSS).
   Results Ten-year cardiovascular risk was 5.16% inpatients with schizophrenia, and 3.02% in control group (p=0.030). No significant correlation was found between FRS scores, SANS, SAPS, and CDSS scores. However, FRS scores were significantly correlated with age, number of hospitalizations and duration of disease (r=0.300, 0.261, 0.252, respectively). Moreover FRS scores were higher (p-0.008) and high-density lipoprotein (HD) levels were lower (p=0.048) in patients using multiple antipsychotics.
   Conclusion Our findings suggest a relationship between the risk of cardiovascular disease and the duration and overall severity of schizophrenia and also highlights the role of antipsychotics in this relationship.
C1 [Kilicaslan, Esin Evren; Karakilic, Merve; Erol, Almila] Izmir Katip Celebi Univ, Ataturk Educ & Training Hosp, Dept Psychiat, TR-35150 Izmir, Turkey.
C3 Izmir Ataturk Training & Research Hospital; Izmir Katip Celebi
   University
RP Kilicaslan, EE (corresponding author), Izmir Katip Celebi Univ, Ataturk Educ & Training Hosp, Dept Psychiat, TR-35150 Izmir, Turkey.
EM esiniyidogan@gmail.com
RI Kilicaslan, Esin/HRD-8727-2023
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NR 69
TC 5
Z9 5
U1 0
U2 2
PU KOREAN NEUROPSYCHIATRIC ASSOC
PI SEOUL
PA RN 522, G-FIVE CENTRAL PLAZA 1685-8 SEOCHO 4-DONG, SEOCHO-GU, SEOUL,
   137-882, SOUTH KOREA
SN 1738-3684
EI 1976-3026
J9 PSYCHIAT INVEST
JI Psychiatry Investig.
PD DEC
PY 2019
VL 16
IS 12
BP 933
EP 939
DI 10.30773/pi.2019.0063
PG 7
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA JX4NW
UT WOS:000503714000009
PM 31801314
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Bogdanet, D
   Egan, A
   Fhelelboom, N
   Biesty, L
   Thangaratinam, S
   Dempsey, E
   Crowther, C
   Devane, D
   Dunne, F
AF Bogdanet, Delia
   Egan, Aoife
   Fhelelboom, Narjes
   Biesty, Linda
   Thangaratinam, Shakila
   Dempsey, Eugene
   Crowther, Caroline
   Devane, Declan
   Dunne, Fidelma
TI Metabolic follow-up at one year and beyond of women with gestational
   diabetes treated with insulin and/or oral hypoglycaemic agents: study
   protocol for the identification of a core outcomes set using a Delphi
   survey
SO TRIALS
LA English
DT Article
DE Core outcome set; Gestational diabetes; Insulin; Oral hypoglycaemic
   agents
ID MELLITUS; ASSOCIATION; PREVALENCE; PREGNANCY; RISK
AB BackgroundGestational diabetes (GDM) is associated with an increased lifetime risk for the development of glucose abnormalities, metabolic syndrome, cardiovascular disease, depression and tumours. Despite this high risk of additional comorbidities, there is no standardised approach to the long-term follow-up of women with a previous diagnosis of GDM. Also, there is no standardisation of outcome selection and reporting in studies involving this population. This increases the risk of reporting bias and reduces the possibility of meaningful comparisons between studies. The aim of this study is to develop a protocol for a core outcome set (COS) for the metabolic follow-up at 1 year and beyond of women with previous GDM treated with insulin and/or oral hypoglycaemic agents.Methods/designThis protocol will describe the steps that will be taken in order to develop the COS. The study will consist of three parts: (1) A systematic review of the literature of the outcomes reported in previous randomised controlled trials of the follow-up at 1 year and beyond of women with GDM treated with insulin and/or oral hypoglycaemic agents; (2) A three-round, online Delphi survey with key stakeholders in order to prioritise these outcomes; and (3) A consensus meeting where the final COS will be decided.DiscussionThe proposed protocol is the first step in developing a COS that will bring consistency and uniformity to outcome selection and reporting in GDM women treated with insulin and/or oral hypoglycaemic agents.
C1 [Bogdanet, Delia; Egan, Aoife; Fhelelboom, Narjes; Biesty, Linda; Devane, Declan; Dunne, Fidelma] Natl Univ Ireland Galway, Coll Med Nursing & Hlth Sci, Galway, Ireland.
   [Thangaratinam, Shakila] Queen Mary Univ London, Womens Hlth Res Unit London, London, England.
   [Dempsey, Eugene] Univ Coll Cork, Paediat & Child Hlth, Cork, Ireland.
   [Crowther, Caroline] Univ Auckland, Liiggins Inst, Auckland, New Zealand.
C3 Ollscoil na Gaillimhe-University of Galway; University of London; Queen
   Mary University London; University College Cork; University of Auckland
RP Bogdanet, D (corresponding author), Natl Univ Ireland Galway, Coll Med Nursing & Hlth Sci, Galway, Ireland.
EM deliabogdanet@gmail.com
RI Dempsey, Eugene/AAG-3037-2021; Bogdanet, Delia/R-8263-2017;
   Thangaratinam, Shakila/AAP-3724-2021; Dempsey, Eugene
   Michael/H-8051-2015; Devane, Declan/B-8357-2008
OI Dempsey, Eugene Michael/0000-0002-6266-3462; Biesty,
   Linda/0000-0002-1108-1518; Thangaratinam, Shakila/0000-0002-4254-460X;
   Egan, Aoife/0000-0003-0379-9279; Dunne, Fidelma/0000-0003-3682-9403;
   Bogdanet, Delia/0000-0001-6127-5049; Devane, Declan/0000-0002-9393-7075
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NR 23
TC 6
Z9 6
U1 0
U2 3
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1745-6215
J9 TRIALS
JI Trials
PD JAN 5
PY 2019
VL 20
AR 9
DI 10.1186/s13063-018-3059-8
PG 7
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA HG3WS
UT WOS:000454906300002
PM 30611300
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Ishida, A
   Nakanishi, R
   Miyagi, T
   Sakima, H
   Nakamura, K
   Yamazato, M
   Ohya, Y
   Kusunose, K
AF Ishida, Akio
   Nakanishi, Rino
   Miyagi, Tomo
   Sakima, Hirokuni
   Nakamura, Koshi
   Yamazato, Masanobu
   Ohya, Yusuke
   Kusunose, Kenya
TI Association of Obesity and Metabolic Health Status with Cerebral
   Small-Vessel Disease in Stroke-Free Individuals
SO JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
LA English
DT Article; Early Access
DE Cerebral small-vessel disease; Metabolically healthy; Obesity
ID CARDIOVASCULAR-DISEASE; SCIENTIFIC STATEMENT; ISCHEMIC-STROKE; RISK;
   IDENTIFICATION; DEPRESSION
AB Aim: We investigated the association of obesity and metabolic health status with cerebral small-vessel disease (SVD), a predictor of stroke, in stroke-free participants during brain health checkups. Methods: An observational cross-sectional study was conducted on 6,088 stroke-free participants who underwent brain magnetic resonance imaging (MRI). Abdominal obesity was defined as a waist circumference >= 90 cm for men and >= 80 cm for women. A metabolically healthy status was defined as having none of the three components of metabolic syndrome, except abdominal obesity. The total SVD scores were derived from four MRI markers: silent lacunar infarcts, cerebral microbleeds, moderate-to-severe white-matter hyperintensity, and enlarged perivascular spaces. Results: The mean age of participants was 55 +/- 12 years old. Obesity was prevalent in 50% of the patients. The prevalence of a total SVD score >= 2 (moderate-to-severe SVD) was 348 (6%), which was elevated in metabolically unhealthy individuals regardless of obesity status. Compared with the metabolically healthy non-obese group, the metabolically unhealthy non-obese (odds ratio [OR] 2.08, [95% confidence interval {CI}, 1.33-3.27]) and metabolically unhealthy obese (OR 2.62, [95% CI, 1.70-4.04]) groups had a higher multivariable-adjusted risk for a total SVD score >= 2. Similar results were obtained for obesity defined as a body mass index >= 25 kg/m(2) instead of abdominal obesity. Conclusions: Abdominal and general obesity alone were not associated with high total SVD scores in stroke-free individuals. Metabolically unhealthy status, especially high blood pressure and hyperglycemia, are significant risk factors for moderate-to-severe SVD.
C1 [Ishida, Akio; Nakanishi, Rino; Miyagi, Tomo; Sakima, Hirokuni; Kusunose, Kenya] Univ Ryukyus, Grad Sch Med, Dept Cardiovasc Med Nephrol & Neurol, 1076 Kiyuna, Ginowan, Okinawa 9012725, Japan.
   [Nakamura, Koshi] Univ Ryukyus, Grad Sch Med, Dept Publ Hlth & Epidemiol, Okinawa, Japan.
   [Yamazato, Masanobu] Okinawa Hlth Promot Fdn, Okinawa, Japan.
   [Ohya, Yusuke] Univ Ryukyus Hosp, Okinawa, Japan.
C3 University of the Ryukyus; University of the Ryukyus
RP Ishida, A (corresponding author), Univ Ryukyus, Grad Sch Med, Dept Cardiovasc Med Nephrol & Neurol, 1076 Kiyuna, Ginowan, Okinawa 9012725, Japan.
EM yaican@med.u-ryukyu.ac.jp
RI ISHIDA, Akio/B-6224-2012; Kusunose, Kenya/AAC-9978-2021
FU Japan Society for the Promotion of Science (JSPS) KAKENHI [21K08281]
FX This work was partly supported by the Japan Society for the Promotion of
   Science (JSPS) KAKENHI, Grant Number 21K08281.
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NR 35
TC 0
Z9 0
U1 0
U2 0
PU JAPAN ATHEROSCLEROSIS SOC
PI TOKYO
PA NICHINAI-KAIKAN B1, 3-28-8 HONGO BUNKYO-KU, TOKYO, 113-0033, JAPAN
SN 1340-3478
EI 1880-3873
J9 J ATHEROSCLER THROMB
JI J. Atheroscler. Thromb.
PD 2025 APR 10
PY 2025
DI 10.5551/jat.65649
EA APR 2025
PG 12
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 1JK1K
UT WOS:001466437600001
PM 40204498
DA 2025-06-11
ER

PT J
AU Mohammadi, S
   Lotfi, K
   Mokhtari, E
   Hajhashemy, Z
   Heidari, Z
   Saneei, P
AF Mohammadi, Sobhan
   Lotfi, Keyhan
   Mokhtari, Elahe
   Hajhashemy, Zahra
   Heidari, Zahra
   Saneei, Parvane
TI Association between Mediterranean dietary pattern with sleep duration,
   sleep quality and brain derived neurotrophic factor (BDNF) in Iranian
   adults
SO SCIENTIFIC REPORTS
LA English
DT Article
ID METABOLIC SYNDROME; METAANALYSIS; VALIDITY; OBESITY; DEPRIVATION;
   HIPPOCAMPUS; RELIABILITY; CONSUMPTION; DEPRESSION; VERSION
AB Data on the association between Mediterranean diet, sleep and brain-derived neurotrophic factor (BDNF) were limited in Middle Eastern populations. We examined the association between Mediterranean dietary pattern with sleep quality/quantity, and serum BDNF in Iranian adults. This cross-sectional study was performed among 535 middle-aged adults (54% men), selected by multistage cluster random sampling method. The Pittsburgh sleep quality index and a validated food frequency questionnaire were used to assess sleep quality, sleep quantity, and Mediterranean diet score (MDS). Twelve-hour fasting blood samples were taken to evaluate serum BDNF values. Participants in the highest tertile of MDS, in comparison to those in the lowest tertile, had lower odds of having short sleep (OR = 0.44, 95%CI: 0.21-0.91) and poor sleep quality (OR = 0.48, 95%CI: 0.22-0.96), after adjustment for potential confounders. Among specific domains of sleep quality, lower odds of subjective sleep quality, sleep latency, and daytime dysfunction were associated with increased MDS. Higher adherence to MDS among individuals with overweight or obesity reduced the odds of having short sleep; this relation was not seen among individuals with normal weight. In contrast, the association between sleep quality and the MDS was significant in individuals with normal weight, but not those with overweight or obesity. Participants with higher adherence to MDS had lower odds for low BDNF values; however, this relation was not statistically significant. Overall, Iranian adults with a higher adherence to MDS had considerably lower odds of having short sleep and poor sleep quality. BDNF would not be an intermediate molecule for this connection.
C1 [Mohammadi, Sobhan; Mokhtari, Elahe; Hajhashemy, Zahra; Saneei, Parvane] Isfahan Univ Med Sci, Nutr & Food Secur Res Ctr, Sch Nutr & Food Sci, Dept Community Nutr, POB 81745-151, Esfahan, Iran.
   [Lotfi, Keyhan] Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Community Nutr, Tehran, Iran.
   [Heidari, Zahra] Isfahan Univ Med Sci, Sch Hlth, Dept Biostat & Epidemiol, Esfahan, Iran.
C3 Isfahan University of Medical Sciences; Tehran University of Medical
   Sciences; Isfahan University of Medical Sciences
RP Saneei, P (corresponding author), Isfahan Univ Med Sci, Nutr & Food Secur Res Ctr, Sch Nutr & Food Sci, Dept Community Nutr, POB 81745-151, Esfahan, Iran.
EM saneeip@yahoo.com
RI Saneei, Parvane/T-5434-2019; heidari, zahra/AAO-8370-2021; Lotfi,
   Keyhan/GRO-4022-2022
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NR 76
TC 5
Z9 5
U1 1
U2 4
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD AUG 18
PY 2023
VL 13
IS 1
DI 10.1038/s41598-023-40625-4
PG 13
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA P5RJ1
UT WOS:001051244000003
PM 37596403
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Haddad, HW
   Boardman, E
   Williams, B
   Mouhaffel, R
   Kaye, AM
   Kaye, AD
AF Haddad, Hannah W.
   Boardman, Elena
   Williams, Brooke
   Mouhaffel, Rama
   Kaye, Adam M.
   Kaye, Alan D.
TI Combination Olanzapine and Samidorphan for the Management of
   Schizophrenia and Bipolar 1 Disorder in Adults: A Narrative Review
SO HEALTH PSYCHOLOGY RESEARCH
LA English
DT Review
DE Schizophrenia; Bipolar Disorder; Lybalvi; samidorphan; olanzapine
ID CHILDHOOD TRAUMA; ECONOMIC BURDEN; RISK-FACTORS; WEIGHT-GAIN; T-CELLS;
   METAANALYSIS; IMPACT; PATHOPHYSIOLOGY; ACTIVATION; DEPRESSION
AB Schizophrenia is a debilitating psychotic disorder characterized by positive symptoms such as delusions, hallucinations, and disorganized thoughts, and negative symptoms like lack of effect or motivation. Bipolar 1 disorder (B1D) is a psychiatric illness characterized by recurrent manic episodes in alternation with depressive episodes and interspersed periods of euthymia, ultimately resulting in psychological distress and impairment of daily functioning. Effective treatments are needed for both schizophrenia and B1D to reach the treatment goals of reducing the debilitating symptomology, improving social functioning and quality of life, and increasing the chances of recovery and more favorable long-term outcomes. To date, olanzapine is one of the most efficacious atypical antipsychotics (AAPs) for the treatment of both schizophrenia and B1D and is associated with fewer extrapyramidal effects compared to other treatments. However, compared to other AAPs, olanzapine is associated with a greater chance of metabolic syndrome, limiting its clinical use and affecting treatment compliance. Samidorphan mitigates the weight gain side effects of olanzapine by antagonizing mu-,.-, and d-opioid receptors. The use of combination drugs to treat psychiatric conditions is an emerging field with the goal of increasing therapeutic efficacy and decreasing undesirable side effects. Clinical trials have demonstrated combination on olanzapine and samidorphan (OLZ/SAM) treatment resulted in significantly less weight gain than olanzapine monotherapy. Clinical trial patients reported improvements in symptoms of psychosis, reduced weight gain, and overall satisfaction with their treatment. OLZ/SAM has been as shown to be a safe and effective pharmaceutical option for the clinical management of schizophrenia and B1D.
C1 [Haddad, Hannah W.] Kansas City Univ Med & Biosci, Coll Med, Kansas City, MO 64106 USA.
   [Boardman, Elena; Williams, Brooke; Mouhaffel, Rama] Louisiana State Univ Hlth Shreveport, Coll Med, Shreveport, LA USA.
   [Kaye, Adam M.] Univ Pacific, Thomas J Long Sch Pharm & Hlth Sci, Dept Pharm Practice, Stockton, CA USA.
   [Kaye, Alan D.] Louisiana State Univ Hlth Shreveport, Dept Anesthesiol, Shreveport, LA USA.
C3 Kansas City University; Louisiana State University System; Louisiana
   State University Health Sciences Center at Shreveport; University of the
   Pacific; Louisiana State University System; Louisiana State University
   Health Sciences Center at Shreveport
RP Haddad, HW (corresponding author), Kansas City Univ Med & Biosci, 1750 Independence Ave, Kansas City, MO 64106 USA.
EM hhaddad@kansascity.edu
RI Kaye, Adam/ABG-8812-2021
OI Haddad, Hannah/0000-0003-1676-6214
CR Alkermes Announces, BIOSPACE
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NR 122
TC 5
Z9 5
U1 0
U2 1
PU OPEN MEDICAL PUBL LLC
PI SCOTTSDALE
PA 14624 N 55 ST, SCOTTSDALE, AZ, UNITED STATES
SN 2420-8124
J9 HEALTH PSYCHOL RES
JI Health Psychol. Res.
PY 2022
VL 10
IS 2
DI 10.52965/001c.34224
PG 16
WC Psychology, Clinical
WE Emerging Sources Citation Index (ESCI)
SC Psychology
GA 8N3PA
UT WOS:000925060500006
PM 35774916
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Zhao, N
   Tao, KX
   Wang, GB
   Xia, ZF
AF Zhao, Ning
   Tao, Kaixiong
   Wang, Guobin
   Xia, Zefeng
TI Global obesity research trends during 1999 to 2017 A bibliometric
   analysis
SO MEDICINE
LA English
DT Article
DE bariatric surgery; bibliometric analysis; obesity; research trends
ID LAPAROSCOPIC SLEEVE GASTRECTOMY; BODY-MASS INDEX; BARIATRIC SURGERY;
   INFLAMMATION; OVERWEIGHT; MORTALITY; THERAPY; CANCER
AB Background: The interest in obesity has considerably increased in the scientific community in the last 2 decades. We present a bibliometric analysis to find out the future research hotspot and trends of obesity.
   Methods: Data were based on the Science Citation Index Expanded (SCI-E), from the Institute of Scientific Information Web of Science database and the 5-year impact factor of a journal were issued from the Journal Citation Reports (JCR) in 2017. Articles referring to obesity during 1999 to 2017 were concentrated on the analysis by scientific output characters and the frequency of author keywords used.
   Results: Globally, 50,246 articles meet the inclusion criteria during 1999 to 2017. The cumulative number of publication about obesity followed exponential distribution (R-2= 0.9974) from 2008. USA was the most productive countries in both independent and international collaborative papers, the countries/ regions with the highest average Times Cited scores for independent articles was France and The United Kingdom scored the highest in average Times Cited for international collaborative papers. Collaboration among countries, playing an ever-growing role in contemporary scientific research. The 2 most prolific journals are Obesity Surgery and International Journal of Obesity, responsible for 3.95% of the publication.
   Conclusion: Obesity has been a field of intense research in the last 19 years. By reasonably analyzing the author keywords and the distribution of journals, "bariatric surgery" (especially "sleeve gastrectomy") and "obese complications" (especially "diabetes mellitus," "metabolic syndrome," "depression," and "polycystic ovary syndrome") will undoubtedly maintain the hotspots of obesity research in the next few decades.
C1 [Zhao, Ning; Tao, Kaixiong; Wang, Guobin; Xia, Zefeng] Huazhong Univ Sci & Technol, Tongji Med Coll, Union Hosp, Dept Gastrointestinal Surg, Wuhan 430022, Hubei, Peoples R China.
C3 Huazhong University of Science & Technology
RP Xia, ZF (corresponding author), Huazhong Univ Sci & Technol, Tongji Med Coll, Union Hosp, Dept Gastrointestinal Surg, Wuhan 430022, Hubei, Peoples R China.
EM zhaoning_hust@126.com
RI Wang, Guobin/AEJ-1468-2022
FU National Key Basic Research Program of China [2015CB5540007]; National
   Natural Science Foundation of China [81472740]; Natural Science
   Foundation of Hubei Province of China [2014CFA060]; Research Fund of
   Public Welfare in Health Industry, Health and Family Plan Committee of
   China [201402015]
FX This study was supported by grants from National Key Basic Research
   Program of China (No. 2015CB5540007); National Natural Science
   Foundation of China (No. 81472740); Natural Science Foundation of Hubei
   Province of China (No. 2014CFA060) and Research Fund of Public Welfare
   in Health Industry, Health and Family Plan Committee of China (No.
   201402015).
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NR 35
TC 33
Z9 34
U1 8
U2 46
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD JAN
PY 2019
VL 98
IS 4
AR e14132
DI 10.1097/MD.0000000000014132
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA HQ3FY
UT WOS:000462296900026
PM 30681576
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Krysiak, R
   Drosdzol-Cop, A
   Skrzypulec-Plinta, V
   Okopien, B
AF Krysiak, Robert
   Drosdzol-Cop, Agnieszka
   Skrzypulec-Plinta, Violetta
   Okopien, Boguslaw
TI Sexual functioning and depressive symptoms in women with various types
   of prediabetes - a pilot study
SO ENDOKRYNOLOGIA POLSKA
LA English
DT Article
DE depressive symptoms; impaired fasting glucose; impaired glucose
   tolerance; sexual functioning
ID IMPAIRED GLUCOSE-TOLERANCE; METABOLIC SYNDROME; PREMENOPAUSAL WOMEN;
   PROLACTIN LEVELS; YOUNG-WOMEN; INDEX FSFI; DYSFUNCTION; METFORMIN;
   ATHEROSCLEROSIS; SIMVASTATIN
AB Introduction: No previous study has investigated sexual functioning in prediabetic women. This study was aimed at investigating sexual function in young women with various types of prediabetes.
   Material and methods: The study included four groups of women: women with isolated impaired fasting glucose (Group A; n = 19), isolated impaired glucose tolerance (Group B; n = 18), presence of both impaired fasting glucose and impaired glucose tolerance (Group C; n = 18), as well as matched healthy controls (Group D; n = 19). All participants completed questionnaires evaluating sexual function (Female Sexual Function Index - FSFI) and the presence and severity of depressive symptoms (Beck Depression Inventory-Second Edition - BDI-II).
   Results: The total FSFI and BDI-II scores were lower in Group C than in the remaining groups of women, while the total FSFI score was lower in Groups A and B than in Group D. Patients with both impaired fasting glucose and impaired glucose tolerance had lower scores in all domains (sexual desire, arousal, lubrication, orgasm, sexual satisfaction, and dyspareunia). Compared to Group D, Group A was characterised by lower domain scores for sexual desire and sexual satisfaction, and Group B by lower domain scores for desire, arousal, and orgasm. In all groups of prediabetic women, the overall FSFI score correlated negatively with the degree of insulin resistance and weakly with the total BDI-II score.
   Conclusions: Impaired fasting glucose and impaired glucose tolerance may disturb sexual functioning and induce depressive symptoms.
C1 [Krysiak, Robert; Okopien, Boguslaw] Med Univ Silesia, Dept Internal Med & Clin Pharmacol, Katowice, Poland.
   [Drosdzol-Cop, Agnieszka; Skrzypulec-Plinta, Violetta] Med Univ Silesia, Sch Hlth Sci Katowice, Chair Womans Hlth, Katowice, Poland.
C3 Medical University of Silesia; Medical University of Silesia
RP Drosdzol-Cop, A (corresponding author), Med Univ Silesia, Chair Womans Hlth, Ul Medykow 12, PL-40752 Katowice, Poland.
EM cor111@poczta.onet.pl
RI Drosdzol-Cop, Agnieszka/AAF-8878-2019; Krysiak, Robert/IQV-2889-2023;
   Drosdzol-Cop, Agnieszka/D-8319-2015
OI Drosdzol-Cop, Agnieszka/0000-0003-1249-5840; Okopien,
   Boguslaw/0000-0001-7228-2906; Skrzypulec-Plinta,
   Violetta/0000-0001-6205-4627; Krysiak, Robert/0000-0001-5454-2620
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TC 5
Z9 5
U1 0
U2 2
PU VIA MEDICA
PI GDANSK
PA UL SWIETOKRZYSKA 73, 80-180 GDANSK, POLAND
SN 0423-104X
J9 ENDOKRYNOL POL
JI Endokrynol. Pol.
PD MAR-APR
PY 2018
VL 69
IS 2
BP 175
EP 181
DI 10.5603/EP.2018.0021
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA GL1NI
UT WOS:000436869500010
PM 29952425
OA gold
DA 2025-06-11
ER

PT J
AU Zheng, YS
   Zhang, GL
   Chen, ZL
   Zeng, Q
AF Zheng, Yansong
   Zhang, Guilan
   Chen, Zhilai
   Zeng, Qiang
TI Association between Age at Menarche and Cardiovascular Disease Risk
   Factors in China: A Large Population-Based Investigation
SO CARDIORENAL MEDICINE
LA English
DT Article
DE Age at menarche; Cardiovascular disease; Risk factors; Large population
ID CORONARY-HEART-DISEASE; METABOLIC-SYNDROME; MYOCARDIAL-INFARCTION;
   POSTMENOPAUSAL WOMEN; REPRODUCTIVE HISTORY; YOUNG FINNS; MORTALITY;
   MENOPAUSE; HEALTH; DEPRESSION
AB Background: The association between age at menarche (AAM) and cardiovascular disease (CVD) has previously been investigated with controversial results. The relationship between the psychological characteristic of AAM and many cardiovascular risk factors remains unclear. Purpose: To assess the association between AAM and CVD risk factors in a large population. Design and Setting: 13,242 women aged 24-79 years were recruited from China mainland during 2009-2013 for a cross-sectional, population-based study to investigate the association between AAM and CVD risk factors. Information on AAM was obtained from self-report and information on CVD risk factors from physical examination. Results: In age-, body-mass-index- and height-adjusted analyses, AAM was positively associated with hypertension and 'college or above' educational level and incident CVD events. The adjusted odds ratios (ORs) and 95% confidence intervals for hypertension across AAM categories (<= 12, 13-14, 15-16, and >= 17 years) were 0.820 (0.70-0.96), 0.82 (0.70-0.96), 0.88 (0.79-0.99) and 1 (referent), respectively; adjusted ORs for high educational level ('college or above') were 0.29 (0.24-0.34), 0.60 (0.41-0.51), 0.69 (0.62-0.76), and 1 (referent), respectively; adjusted ORs for incident CVD events were 0.18 (0.08-0.41), 0.18 (0.08-0.41), 0.62 (0.41-0.93), 1 (referent), respectively. Conclusions: Earlier AAM were positively associated with incident CVD events, hypertension and 'college or above' educational level. (C) 2016 S. Karger AG, Basel.
C1 [Zheng, Yansong; Chen, Zhilai; Zeng, Qiang] Chinese Peoples Liberat Army Gen Hosp, Hlth Management Inst, FuXing Rd 28, Beijing 100853, Peoples R China.
   [Zeng, Qiang] Chinese Peoples Liberat Army Gen Hosp, Dept Geriatr Cardiol, Beijing, Peoples R China.
   [Zhang, Guilan] Huazhong Univ Sci & Technol, Tongji Med Coll, Cent Hosp Xiaogan Hlth Examinat, Xiaogan, Peoples R China.
C3 Chinese People's Liberation Army General Hospital; Chinese People's
   Liberation Army General Hospital; Huazhong University of Science &
   Technology
RP Zeng, Q (corresponding author), Chinese Peoples Liberat Army Gen Hosp, Hlth Management Inst, FuXing Rd 28, Beijing 100853, Peoples R China.
EM zq301@126.com
OI zheng, yan song/0000-0002-3491-7672
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NR 43
TC 11
Z9 12
U1 0
U2 4
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1664-3828
EI 1664-5502
J9 CARDIORENAL MED
JI CardioRenal Med.
PY 2016
VL 6
IS 4
BP 307
EP 316
DI 10.1159/000445506
PG 10
WC Cardiac & Cardiovascular Systems; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Cardiovascular System & Cardiology; Urology & Nephrology
GA DT7GW
UT WOS:000381656100006
PM 27648012
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Llaneza, P
   Iñarrea, J
   Gonzalez, C
   Alonso, A
   Arnotta, I
   Ferrer-Barriendos, J
AF Llaneza, Placido
   Inarrea, Jose
   Gonzalez, Celestino
   Alonso, Ana
   Arnotta, Ignacio
   Ferrer-Barriendos, Javier
TI Differences in health related quality of life in a sample of Spanish
   menopausal women with and without obesity
SO MATURITAS
LA English
DT Article
DE menopause; health related quality of life; abdominal obesity; obesity;
   Cervantes scale
ID METABOLIC SYNDROME; BODY-COMPOSITION; WEIGHT; ASSOCIATION; FAT
AB Objective: To investigate whether body mass index, abdominal obesity or fat distribution in postmenopausal women influence their quality of Life. Methods: A cross-sectional study was carried out on 250 postmenopausal women (age: 50-64 years), with intact uterus and ovaries, sexually active, and non-hormone therapy users. Various anthropometric measurements were considered and a specific health-related quality of life (HR-QoL) instrument, the Cervantes scale, was performed. Results: Thirty-three women were not included as they refused to participate in the study, had chronic disease such as hypertension, diabetes type 2, depression or did not answer all the scale items, so 217 patients were evaluated. According with BMI values, 34% of women were obese, 46.1% were in overweight, 19.8% were in normal weight and there were not underweight women. Any consistent relation was found between BMI and global values of HR-QoL, but obese women were diagnosed with "high level of problems" in the "psychical domain" and in the "sexuality domain". This difference in "sexuality domain" was also appreciated in women with abdominal obesity. Fat or lean mass was not correlated with HR-QoL. Conclusion: In our study, obesity did not affect the global HR-QoL in Spanish postmenopausal women, but could have an influence on the psychical and sexual domains. Others anthropometric measurements are not associated with changes in HR-QoL. Additional research with HR-QoL specific and validated instruments and with a longitudinal design seems necessary to confirm our results. (c) 2007 Elsevier Ireland Ltd. All rights reserved.
C1 [Llaneza, Placido; Arnotta, Ignacio; Ferrer-Barriendos, Javier] Cent Univ Hosp Asturias, Oviedo 33006, Spain.
   [Inarrea, Jose] Cabuenes Hosp, Gijon 33203, Spain.
   [Gonzalez, Celestino; Alonso, Ana] Univ Oviedo, Sch Med, Dept Phys, Oviedo 33006, Spain.
C3 Central University Hospital Asturias; Hospital Universitario de
   Cabuenes; University of Oviedo
RP Llaneza, P (corresponding author), Cent Univ Hosp Asturias, C Celestino Villamil S-N, Oviedo 33006, Spain.
EM pflanezac@yahoo.es; jfi@telefonica.net; tinog@correo.uniovi.es;
   tinog@correo.uniovi.es; ignacio-arnott@hotmail.com;
   Javier-ferrer@telecable.es
RI Llaneza, Placido/AAJ-8974-2020; inarrea, jesus/L-1254-2014;
   Gonzalez-Gonzalez, Celestino/A-2323-2008
OI inarrea, jesus/0000-0003-3168-7733; Alonso Garcia,
   Ana/0000-0003-4679-1744; Gonzalez-Gonzalez,
   Celestino/0000-0001-7309-9003; Llaneza Coto, Placido/0000-0002-6735-4618
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NR 25
TC 26
Z9 30
U1 0
U2 8
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0378-5122
EI 1873-4111
J9 MATURITAS
JI Maturitas
PD DEC 20
PY 2007
VL 58
IS 4
BP 387
EP 394
DI 10.1016/j.maturitas.2007.09.013
PG 8
WC Geriatrics & Gerontology; Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology; Obstetrics & Gynecology
GA 248QC
UT WOS:000252168300007
PM 17997059
DA 2025-06-11
ER

PT J
AU Kemse, N
   Kale, A
   Joshi, S
AF Kemse, N.
   Kale, A.
   Joshi, S.
TI Maternal supplementation of omega-3 fatty acids and micronutrients
   reduces cardiometabolic variables in pregnancy induced hypertension rats
SO LIFE SCIENCES
LA English
DT Article
DE Docosahexaenoic acid; Folate; Metabolic markers; Pregnancy induced
   hypertension; Vitamin B-12
ID POLYUNSATURATED FATTY-ACIDS; PREECLAMPSIA-LIKE SYMPTOMS; EARLY
   GESTATIONAL STAGE; FOLIC-ACID; BLOOD-PRESSURE; CARDIOVASCULAR-DISEASE;
   OXIDATIVE STRESS; WISTAR RATS; ERYTHROCYTE OMEGA-3; BRAIN NEUROTROPHINS
AB Aims: Reports indicate that during pregnancy hypertension is known to have long term adverse effects both in the mother and offspring. However, the effect of maternal micronutrient supplementation on this association of in utero exposure and risk of non-communicable diseases in the later life remains unclear. The present study examines the effect of maternal micronutrient and omega-3 fatty acid supplementation either individual or in combination on cardiometabolic risk factors both in the mother and offspring using an animal model of hypertension.
   Main methods: Pregnant Wistar rats were randomly assigned to the following groups; control, PIH (Pregnancy induced hypertention) Induced, PIH + vitamin B-12, PIH + folic acid, PIH + omega-3 fatty acids and PIH + combined smicronutrient supplementation (vitamin B-12 + folic acid + omega-3 fatty acids). The dams and their offspring were shifted to a control diet after delivery and the offspring continued on these diets till 3 mo of age. Hypertension during pregnancy was induced using L-Nitroarginine methylester (50 mg/kg body weight/day).
   Key findings: Omega-3 fatty acid supplementation during pregnancy demonstrated lower levels (p < 0.05) of plasma cholesterol while a combined supplementation of folic acid, vitamin B-12 and omega 3 fatty acids demonstrated lower (p < 0.05) triglyceride levels as compared to PIH induced dams. PIH induction increased (p < 0.01) the triglyceride levels in the offspring at 3 mo of age and maternal supplementation of either individual or combined micronutrients demonstrated lower (p < 0.01) triglyceride levels.
   Significance: Our findings have implications for planning intervention studies in women with pregnancy induced hypertension. (C) 2016 Elsevier Inc. All rights reserved.
C1 [Kemse, N.; Kale, A.; Joshi, S.] Bharati Vidyapeeth Deemed Univ, Dept Nutr Med, Interact Res Sch Hlth Affairs, Pune Satara Rd, Pune 411043, Maharashtra, India.
C3 Bharati Vidyapeeth Deemed University
RP Joshi, S (corresponding author), Bharati Vidyapeeth Deemed Univ, Dept Nutr Med, Interact Res Sch Hlth Affairs, Pune Satara Rd, Pune 411043, Maharashtra, India.
EM srjoshi62@gmail.com
OI , Dr. Anvita/0000-0001-5877-8999
FU Department of Biotechnology (Govt. of India), New Delhi India
   [BT/PR6472/FNS/20/656/2012]
FX The authors acknowledge the Department of Biotechnology (Govt. of
   India), New Delhi India for financial support. (Grant no. DBT No:
   BT/PR6472/FNS/20/656/2012).
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NR 59
TC 4
Z9 4
U1 0
U2 38
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0024-3205
EI 1879-0631
J9 LIFE SCI
JI Life Sci.
PD JUN 15
PY 2016
VL 155
BP 85
EP 93
DI 10.1016/j.lfs.2016.05.016
PG 9
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA DO1LW
UT WOS:000377540700012
PM 27181745
DA 2025-06-11
ER

PT J
AU Deckers, K
   Köhler, S
   van Boxtel, M
   Verhey, F
   Brayne, C
   Fleming, J
AF Deckers, Kay
   Kohler, Sebastian
   van Boxtel, Martin
   Verhey, Frans
   Brayne, Carol
   Fleming, Jane
CA CC75C Study Collaboration
TI Lack of associations between modifiable risk factors and dementia in the
   very old: findings from the Cambridge City over-75s cohort study
SO AGING & MENTAL HEALTH
LA English
DT Article
DE Dementia; epidemiology; prevention; risk factors; cohort study
ID MINI-MENTAL-STATE; COGNITIVE DECLINE; ALZHEIMERS-DISEASE; METABOLIC
   SYNDROME; BLOOD-PRESSURE; LATE-LIFE; PREVENTION; ADULTS
AB Objectives: To investigate the association between modifiable risk and protective factors and severe cognitive impairment and dementia in the very old. Additionally, the present study tests the predictive validity of the LIfestyle for BRAin health' (LIBRA) score, an index developed to assess an individual's dementia prevention potential.Method: Two hundred seventy-eight individuals aged 85years or older from the Cambridge City over-75s cohort study were followed-up until death. Included risk and protective factors were: diabetes, heart disease, hypertension, depression, smoking, low-to-moderate alcohol use, high cognitive activity, and physical inactivity. Incident severe cognitive impairment was based on the Mini-Mental State Examination (score: 0-17) and incident dementia was based on either post-mortem consensus clinical diagnostic assessments or death certificate data. Logistic regressions were used to test whether individual risk and protective factors and the LIBRA score were associated with severe cognitive impairment or dementia after 18years follow-up.Results: None of the risk and protective factors or the LIBRA score was significantly associated with increased risk of severe cognitive impairment or dementia. Sensitivity analyses using a larger sample, longer follow-up period, and stricter cut-offs for prevalent cognitive impairment showed similar results.Conclusion: Associations between well-known midlife risk and protective factors and risk for severe cognitive impairment or dementia might not persist into very old age, in line with suggestions that targeting these factors through lifestyle interventions should start earlier in life.
C1 [Deckers, Kay; Kohler, Sebastian; van Boxtel, Martin; Verhey, Frans] Maastricht Univ, Sch Mental Hlth & Neurosci, Alzheimer Ctr Limburg, Maastricht, Netherlands.
   [Brayne, Carol; Fleming, Jane] Univ Cambridge, Cambridge Inst Publ Hlth, Cambridge, England.
   [Brayne, Carol; Fleming, Jane] Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England.
C3 Maastricht University; University of Cambridge; University of Cambridge
RP Deckers, K (corresponding author), Maastricht Univ, Sch Mental Hlth & Neurosci, Alzheimer Ctr Limburg, Maastricht, Netherlands.
EM kay.deckers@maastrichtuniversity.nl
RI Brayne, Carol/AAA-4285-2020; Fleming, Jane/L-5300-2015; Kohler,
   Sebastian/B-2398-2009
OI Verhey, Frans/0000-0002-8307-8406; Fleming, Jane/0000-0002-8127-2061;
   Brayne, Carol/0000-0001-5307-663X; Kohler, Sebastian/0000-0002-2398-0609
FU Alzheimer Nederland [WE.15-2015-01]; Alzheimer's Society UK
   [WE.15-2015-01]; Abbeyfield Society; National Institute for Health
   Research; CC75C
FX Exchange fellowship Alzheimer Nederland/Alzheimer's Society UK. This
   work was supported by a fellowship (Kay Deckers) from Alzheimer
   Nederland and the Alzheimer's Society UK [grant number WE.15-2015-01].
   We thank all the past CC75C sponsors for financial support spanning two
   decades (see http://www.cc75c.group.cam.ac.uk/background/grants/for full
   list of project grants), particularly the Abbeyfield Society for current
   funding. CC75C was a member study of the National Institute for Health
   Research funded Collaboration for Leadership in Applied Health Research
   & Care (CLAHRC) for Cambridgeshire and Peterborough. All researchers
   were independent from funders. No funder sponsor played any role in
   study design, data collection and analysis, decision to publish or
   preparation of the manuscript.
CR [Anonymous], 2016, Group interview with representatives from the Stabilisation Unit (UK)
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   World Health Organization, 2012, DEM PUBL HLTH PRIOR
NR 29
TC 37
Z9 40
U1 0
U2 9
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 1360-7863
EI 1364-6915
J9 AGING MENT HEALTH
JI Aging Ment. Health
PY 2018
VL 22
IS 10
BP 1272
EP 1278
DI 10.1080/13607863.2017.1280767
PG 7
WC Geriatrics & Gerontology; Gerontology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Psychiatry
GA HH1PG
UT WOS:000455491500005
PM 28151002
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Shabsigh, R
   Kaufman, J
   Magee, M
   Creanga, D
   Russell, D
   Budhwani, M
AF Shabsigh, Ridwan
   Kaufman, Joel
   Magee, Michelle
   Creanga, Dana
   Russell, David
   Budhwani, Meeta
TI A Multicenter, Double-blind, Placebo-controlled Trial to Assess The
   Efficacy of Sildenafil Citrate in Men With Unrecognized Erectile
   Dysfunction
SO UROLOGY
LA English
DT Article
ID METABOLIC SYNDROME; RISK-FACTORS; CARDIOVASCULAR-DISEASE;
   TREATMENT-SEEKING; HEART-DISEASE; PREVALENCE; SATISFACTION; ASSOCIATION;
   DEPRESSION; PREDICTOR
AB OBJECTIVE Erectile dysfunction (ED) may be present but unrecognized in men with other comorbidities, such as cardiovascular disease (CVD), diabetes, or lower urinary tract symptoms (LUTS). The efficacy of sildenafil citrate treatment for ED in men who did not self-identify with or were unsure about whether they had ED, but had ED based on International Index of Erectile Function Erectile Function domain (IIEF-EF) scores, was evaluated.
   METHODS Men with an ED-associated comorbidity were asked, "Do you have ED?" Those who answered "no" or "unsure" and were diagnosed with ED (score of <= 25 IIEF-EF) were invited to participate in a parallel-group, multicenter, flexible-dose, double-blind, randomized, placebo-controlled trial, followed by an open-label extension. Erectile function and emotional/psychosocial benefits of sildenafil treatment were assessed.
   RESULTS Men with ED at baseline were randomized to sildenafil (n = 150) or placebo (n = 155). The mean +/- SD number of ED risk factors in the sildenafil and placebo groups was 3.5 +/- 1.8 and 3.3 +/- 1.7, respectively. Hypertension, hypercholesterolemia, smoking, obesity (body mass index >= 30 kg/m(2)), and waist circumference >= 40 inches were the most frequently reported risk factors. Sildenafil-treated men had improved scores on both functional and psychosocial measures. Most adverse events were mild to moderate.
   CONCLUSIONS Many men do not recognize that they have ED; sildenafil treatment improved sexual function and satisfaction in these men. Because ED affects quality of life, it should be suspected and assessed in men with risk factors for ED. UROLOGY 76: 373-379, 2010. (C) 2010 Elsevier Inc.
C1 [Shabsigh, Ridwan] Maimonides Hosp, Brooklyn, NY 11219 USA.
   Columbia Univ, New York, NY USA.
   Georgetown Univ, Sch Med, MedStar Diabet & Res Inst, Washington, DC USA.
   Pfizer Inc, New York, NY USA.
C3 Maimonides Medical Center; Columbia University; Georgetown University;
   Pfizer; Pfizer USA
RP Shabsigh, R (corresponding author), Maimonides Hosp, 904 49th St & 9th Ave, Brooklyn, NY 11219 USA.
EM rshabsigh@maimonidesmed.org
RI Russell, David/IXN-3147-2023
FU Pfizer Inc
FX This study was funded by Pfizer Inc. Editorial support was provided by
   Nancy Price, Ph.D., and Janet E. Matsuura, Ph.D., of Complete Healthcare
   Communications, Inc., and was funded by Pfizer Inc.
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NR 31
TC 10
Z9 10
U1 0
U2 4
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0090-4295
EI 1527-9995
J9 UROLOGY
JI Urology
PD AUG
PY 2010
VL 76
IS 2
BP 373
EP 379
DI 10.1016/j.urology.2010.03.017
PG 7
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 638BR
UT WOS:000280865300042
PM 20579708
DA 2025-06-11
ER

PT J
AU Bruno, OD
   Juarez-Allen, L
   Rossi, MA
   Longobardi, V
AF Bruno, Oscar D.
   Juarez-Allen, Lea
   Alicia Rossi, Maria
   Longobardi, Vanesa
TI IN WHAT CLINICAL SETTINGS SHOULD CUSHING'S SYNDROME BE SUSPECTED?
SO MEDICINA-BUENOS AIRES
LA English
DT Article
DE Cushing's syndrome; hypercortisolism features; clinical manifestations
   of Cushing's syndrome
ID CARDIOVASCULAR RISK; HORMONE-SECRETION; DISEASE; HYPERTENSION;
   DIAGNOSIS; PREVALENCE; CELLS
AB Despite its low frequency, endogenous Cushing's syndrome is not an exceptional clinical entity. A growing number of cases are currently derived to specialized centers suggesting an increasing knowledge of the clinical features of hypercortisolism by specialists of diverse branches of clinical medicine. Clinical signs derive from an exaggeration of the physiological actions of cortisol inducing protein breakdown, hyperglycemia, fat mobilization, dyslipidemia, hydrosaline retention, immunosuppression and increased susceptibility to infection. Despite its low specificity, symptoms such as unexplained development of central obesity, mood changes, fatigue, weakness, myopathy, easy bruisability, red striae, arterial hypertension, diabetes and hyperlipidemia, are suggestive of the diagnosis. From an epidemiological point of view, Cushing's syndrome is to be suspected and consequently searched for among patients with uncontrolled high blood pressure or diabetes mellitus, metabolic syndrome, polycystic ovarian syndrome, osteoporosis, depression or adrenal incidentaloma. True Cushing's syndrome has to be differentiated from pseudo syndromes. Most sensitive physical signs for discriminating Cushing's syndrome from pseudo-Cushing states are the presence of supraclavicular fat pads, myopathy, thin skin and easy bruising. The recognition of the clinical manifestations of Cushing's syndrome and of the sub-populations at risk of contracting the disease should be improved through medical education at the medical school and at postgraduate levels. Clinical detection of Cushing's syndrome must be performed mainly by non-endocrinologists, yet its etiological diagnosis and therapeutic management is to be carried out in highly experienced and specialized centers, to ensure the best results in the treatment of this really challenging endocrine disturbance.
C1 [Bruno, Oscar D.; Juarez-Allen, Lea; Alicia Rossi, Maria; Longobardi, Vanesa] Univ Buenos Aires, Div Endocrinol, Hosp Clin, Fac Med, RA-1120 Buenos Aires, DF, Argentina.
C3 University of Buenos Aires
RP Bruno, OD (corresponding author), Univ Buenos Aires, Div Endocrinol, Hosp Clin, Fac Med, Av Cordoba 2351, RA-1120 Buenos Aires, DF, Argentina.
EM bodomingo@intramed.net
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NR 36
TC 8
Z9 9
U1 0
U2 4
PU MEDICINA (BUENOS AIRES)
PI BUENOS AIRES
PA DONATO ALVAREZ 3150, 1427 BUENOS AIRES, ARGENTINA
SN 0025-7680
EI 1669-9106
J9 MEDICINA-BUENOS AIRE
JI Med.-Buenos Aires
PY 2009
VL 69
IS 6
BP 674
EP 680
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 539NJ
UT WOS:000273261300018
PM 20053613
DA 2025-06-11
ER

PT J
AU Vajdi, M
   Nikniaz, L
   Asl, AMP
   Farhangi, MA
AF Vajdi, Mahdi
   Nikniaz, Leila
   Asl, Asghar Mohammad Pour
   Farhangi, Mahdieh Abbasalizad
TI Lifestyle patterns and their nutritional, socio-demographic and
   psychological determinants in a community-based study: A mixed approach
   of latent class and factor analyses
SO PLOS ONE
LA English
DT Article
ID GENERALIZED ANXIETY DISORDER; HEALTH-RISK-BEHAVIORS; PHYSICAL-ACTIVITY;
   METABOLIC SYNDROME; UNIVERSITY-STUDENTS; INSULIN-RESISTANCE;
   NATIONAL-HEALTH; CONSUMPTION; PREVALENCE; SMOKING
AB Background
   Lifestyle risk factors, such as unhealthy diet, physical inactivity or tobacco smoking can have detrimental effects on health and well-being. Therefore, it is important to examine multiple lifestyle risk factors instead of single ones. Cluster analysis allows the combination of single health behaviors in order to recognize distinguished behavior patterns. This study aimed to evaluate lifestyle patterns of general adult population in northwest of Iran with particular focus on dietary patterns, physical activity, and smoking status.
   Methods
   The current cross-sectional study consists of 525 adults aged 18-64 years from East-Azarbaijan Iran. Latent class analysis (LCA) was applied to recognize patterns of lifestyle behaviors with ingredients of diet, physical activity, and smoking status. Dietary intake was assessed using a validated food frequency questionnaire and dietary patterns were derived using factor analysis. Biochemical parameters including fasting blood sugar (FBS), serum lipids, liver enzyme and serum 25(OH)-D3 were measured with commercial ELIZA kits.
   Results
   Mean ages of participants were 42.90 +/- 11.89 years. Using principal component analysis (PCA) three major dietary patterns were extracted including traditional dietary pattern (e.g. nuts and dry fruits), unhealthy dietary pattern (e.g. fast foods, refined grains) and the healthy dietary patterns (e.g. fruits, vegetables). Using LCA, three classes of lifestyles pattern were identified: 1st class was characterized by a healthy dietary pattern, moderate physical activity, and low probability of smoking. 2nd class was characterized by a traditional dietary pattern, low level of physical activity and low probability of smoking and 3rd class was characterized by a unhealthy dietary pattern, low level of physical activity and low probability of smoking and further analysis found that there were significant differences in body mass index (BMI), Waist-to-hip ratio (WHR), FBS, Hemoglobin (Hb), education levels and anxiety status between classes (P<0.05).
   Conclusion
   This study attempts to classify Iranian adults by their own health behavior. Healthcare professionals should be aware of associations between different lifestyle risk factors and health promotion strategies should further focus on multiple behaviors at the same time. In our country, more studies about the adult population are needed to support the observed findings of our study and therefore allow for a certain generalization of the observations.
C1 [Vajdi, Mahdi] Tabriz Univ Med Sci, Student Res Comm, Tabriz, Iran.
   [Nikniaz, Leila] Tabriz Univ Med Sci, Tabriz Hlth Serv Management Res Ctr, Hlth Management & Safety Promot Res Inst, Tabriz, Iran.
   [Asl, Asghar Mohammad Pour] Tabriz Univ Med Sci, Fac Hlth, Hlth & Environm Res Ctr, Dept Epidemiol & Biostat, Tabriz, Iran.
   [Farhangi, Mahdieh Abbasalizad] Tabriz Univ Med Sci, Drug Appl Res Ctr, Tabriz, Iran.
C3 Tabriz University of Medical Science; Tabriz University of Medical
   Science; Tabriz University of Medical Science; Tabriz University of
   Medical Science
RP Farhangi, MA (corresponding author), Tabriz Univ Med Sci, Drug Appl Res Ctr, Tabriz, Iran.
EM abbasalizad_m@yahoo.com
RI Nikniaz, Leila/M-5747-2017; Farhangi, Mahdieh/AAC-6758-2019; Vajdi,
   Mahdi/GZG-7674-2022
OI Vajdi, Mahdi/0000-0002-2828-1161; Abbasalizad Farhangi,
   Mahdieh/0000-0002-7036-6900
FU Research Undersecretary of Tabriz University of Medical Sciences
FX The work has been granted by Research Undersecretary of Tabriz
   University of Medical Sciences (Registration number: IR.TBZMED.
   REC.1398.07) and is obtained from the M.S thesis of Mahdi Vajdi. The
   funders had no role in study design, data collection and analysis,
   decision to publish, or preparation of the manuscript.
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NR 68
TC 18
Z9 20
U1 2
U2 14
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JUL 23
PY 2020
VL 15
IS 7
AR e0236242
DI 10.1371/journal.pone.0236242
PG 16
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Science & Technology - Other Topics
GA NX7VK
UT WOS:000575913700061
PM 32701986
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Skoug, C
   Rogova, O
   Spégel, P
   Holm, C
   Duarte, JMN
AF Skoug, Cecilia
   Rogova, Oksana
   Spegel, Peter
   Holm, Cecilia
   Duarte, Joao M. N.
TI Genetic deletion of hormone-sensitive lipase in mice reduces cerebral
   blood flow but does not aggravate the impact of diet-induced obesity on
   memory
SO JOURNAL OF NEUROCHEMISTRY
LA English
DT Article
DE endocannabinoids; eicosanoids; lipids; memory; vasoconstriction;
   vasodilation
ID MILD COGNITIVE IMPAIRMENT; SPREADING DEPRESSION; TARGETED LIPIDOMICS;
   ALZHEIMERS-DISEASE; BRAIN; TRANSLOCATION; MUSCLE; ACCUMULATION;
   ADIPOCYTES; VALIDATION
AB Hormone-sensitive lipase (HSL) is active throughout the brain and its genetic ablation impacts brain function. Its activity in the brain was proposed to regulate bioactive lipid availability, namely eicosanoids that are inflammatory mediators and regulate cerebral blood flow (CBF). We aimed at testing whether HSL deletion increases susceptibility to neuroinflammation and impaired brain perfusion upon diet-induced obesity. HSL-/-, HSL+/-, and HSL+/+ mice of either sex were fed high-fat diet (HFD) or control diet for 8 weeks, and then assessed in behavior tests (object recognition, open field, and elevated plus maze), metabolic tests (insulin and glucose tolerance tests and indirect calorimetry in metabolic cages), and CBF determination by arterial spin labeling (ASL) magnetic resonance imaging (MRI). Immunofluorescence microscopy was used to determine coverage of blood vessels, and morphology of astrocytes and microglia in brain slices. HSL deletion reduced CBF, most prominently in cortex and hippocampus, while HFD feeding only lowered CBF in the hippocampus of wild-type mice. CBF was positively correlated with lectin-stained vessel density. HSL deletion did not exacerbate HFD-induced microgliosis in the hippocampus and hypothalamus. HSL-/- mice showed preserved memory performance when compared to wild-type mice, and HSL deletion did not significantly aggravate HFD-induced memory impairment in object recognition tests. In contrast, HSL deletion conferred protection against HFD-induced obesity, glucose intolerance, and insulin resistance. Altogether, this study points to distinct roles of HSL in periphery and brain during diet-induced obesity. While HSL-/- mice were protected against metabolic syndrome development, HSL deletion reduced brain perfusion without leading to aggravated HFD-induced neuroinflammation and memory dysfunction.
C1 [Skoug, Cecilia; Holm, Cecilia; Duarte, Joao M. N.] Lund Univ, Fac Med, Dept Expt Med Sci, Lund, Sweden.
   [Skoug, Cecilia; Duarte, Joao M. N.] Lund Univ, Fac Med, Wallenberg Ctr Mol Med, Lund, Sweden.
   [Rogova, Oksana; Spegel, Peter] Lund Univ, Ctr Anal & Synth, Dept Chem, Lund, Sweden.
   [Duarte, Joao M. N.] Lund Univ, Fac Med, Dept Expt Med Sci EMV, Solvegatan 19, BMC C11, S-22184 Lund, Sweden.
C3 Lund University; Lund University; Lund University; Lund University
RP Duarte, JMN (corresponding author), Lund Univ, Fac Med, Dept Expt Med Sci EMV, Solvegatan 19, BMC C11, S-22184 Lund, Sweden.
EM joao.duarte@med.lu.se
RI Skoug, Cecilia/KCY-7907-2024; Spegel, Peter/G-9947-2018; Duarte,
   Joao/H-4887-2012
OI Holm Wallenberg, Cecilia/0000-0002-7496-8167; Spegel,
   Peter/0000-0002-6092-2387; Duarte, Joao/0000-0001-5984-1574; Skoug,
   Cecilia/0000-0002-4999-1939; Rogova, Oksana/0000-0002-5104-2943
FU Diabetesfonden [Dnr STYR 2019/318]; Knut and Alice Wallenberg Foundation
   [Dnr STYR 2021/2984]; Lund University Faculty of Medicine [2009-1039];
   Lund University Diabetes Centre - Swedish Research Council (Strategic
   Research Area EXODIAB) [IRC15-0067]; Swedish Foundation for Strategic
   Research
FX JMND acknowledges support from The Knut and Alice Wallenberg Foundation,
   infrastructure funding of Lund University (Dnr STYR 2019/318) and the
   Lund University Faculty of Medicine (Dnr STYR 2021/2984), and the Lund
   University Diabetes Centre, which is funded by the Swedish Research
   Council (Strategic Research Area EXODIAB; grant no.: 2009-1039) and the
   Swedish Foundation for Strategic Research (grant no.: IRC15-0067).
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NR 59
TC 4
Z9 4
U1 1
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-3042
EI 1471-4159
J9 J NEUROCHEM
JI J. Neurochem.
PD MAY
PY 2024
VL 168
IS 5
BP 781
EP 800
DI 10.1111/jnc.16064
EA FEB 2024
PG 20
WC Biochemistry & Molecular Biology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Neurosciences & Neurology
GA RH1F0
UT WOS:001158077000001
PM 38317494
OA hybrid
DA 2025-06-11
ER

PT J
AU Rech, J
   Sticherling, M
   Stoessel, D
   Biermann, MHC
   Häberle, BM
   Reinhardt, M
AF Rech, Juergen
   Sticherling, Michael
   Stoessel, Daniel
   Biermann, Mona H. C.
   Haeberle, Benjamin M.
   Reinhardt, Maximilian
TI Psoriatic arthritis epidemiology, comorbid disease profiles and risk
   factors: results from a claims database analysis
SO RHEUMATOLOGY ADVANCES IN PRACTICE
LA English
DT Article
DE PsA; psoriasis; comorbid disease; incidence; epidemiology; risk factors;
   insurance health claims data
ID PREVALENCE; POPULATION; PROGRESSION; DIAGNOSIS; GERMANY
AB Objective. Psoriasis is a systemic inflammatory disease often accompanied by comorbidities, including metabolic syndrome, cardiovascular diseases and depression. Up to 41% of psoriasis patients develop psoriatic arthritis (PsA), making it one of the most relevant manifestations. A large health claims data set was analysed to determine the rate of PsA development in psoriasis patients. Furthermore, comorbid disease profiles of psoriasis patients with or without PsA were compared, and potential risk factors for the development of PsA were identified.
   Methods. This was a non-interventional, retrospective analysis of anonymized insurance health claims data using a subset of the Institute of Applied Health Research Berlin (InGef) database. The primary outcome was the prevalence and incidence of diagnosed PsA among psoriasis patients in Germany. Risk factors for the development of PsA in psoriasis patients were determined by conditional logistic regression analysis.
   Results. The cumulative percentage of patients with existing psoriasis developing concomitant PsA over 4 years was 3.44%, with a mean time to diagnosis of PsA of 1.5 years. Psoriasis patients diagnosed with acute rheumatism (odds ratio: 2.93, 95% CI = 1.76, 4.86; P < 0.001) or pain in unspecific joints (odds ratio: 1.74, 95% CI = 1.01, 2.99; P = 0.047) showed an increased risk for development of PsA later on. Interestingly, fewer than half of the patients with concomitant PsA consulted a rheumatologist.
   Conclusions. Unspecific arthritic symptoms are likely to precede PsA diagnoses and can develop soon after onset of psoriasis, with accumulating risk over time. There is a high unmet need for early rheumatological assessment of psoriasis patients.
C1 [Rech, Juergen] Univ Klinikum Erlangen, Dept Internal Med Rheumatol & Immunol 3, Erlangen, Germany.
   [Sticherling, Michael] Univ Klinikum Erlangen, Hautklin, Erlangen, Germany.
   [Stoessel, Daniel] Elsevier Hlth Analyt, Berlin, Germany.
   [Biermann, Mona H. C.; Haeberle, Benjamin M.; Reinhardt, Maximilian] Novartis Pharma GmbH, Nurnberg, Germany.
C3 University of Erlangen Nuremberg; University of Erlangen Nuremberg; Reed
   Elsevier; Elsevier; Novartis; Novartis Germany
RP Rech, J (corresponding author), Univ Klinikum Erlangen, Dept Internal Med Rheumatol & Immunol 3, Erlangen, Germany.
EM juergen.rech@uk-erlangen.de
OI Haberle, Benjamin/0000-0001-9403-0136; Biermann,
   Mona/0000-0003-0496-5988
FU Novartis Pharma GmbH, Nurnberg, Germany
FX This analysis was supported by Novartis Pharma GmbH, Nurnberg, Germany.
   All authors participated in data collection and/or analysis
   design/conduct.
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NR 37
TC 17
Z9 17
U1 0
U2 2
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
EI 2514-1775
J9 RHEUMATOL ADV PRACT
JI Rheumatol. Adv. Pract.
PY 2020
VL 4
IS 2
AR rkaa033
DI 10.1093/rap/rkaa033
PG 9
WC Rheumatology
WE Emerging Sources Citation Index (ESCI)
SC Rheumatology
GA PR8QQ
UT WOS:000607497700021
PM 33134811
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Kim, E
   Lee, SH
   Lee, KS
   Cheong, HK
   Namkoong, K
   Hong, CH
   Oh, BH
AF Kim, Eosu
   Lee, Sung Hee
   Lee, Kang Soo
   Cheong, Hae-Kwan
   Namkoong, Kee
   Hong, Chang Hyung
   Oh, Byoung Hoon
TI AMPK γ2 subunit gene PRKAG2 polymorphism associated with
   cognitive impairment as well as diabetes in old age
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE AMP-activated protein kinase; Cognitive impairment; Diabetes; Genetic
   polymorphism
ID ACTIVATED PROTEIN-KINASE; ALZHEIMER-DISEASE; METABOLIC SYNDROME;
   MITOCHONDRIAL DYSFUNCTION; INSULIN-RESISTANCE; DEMENTIA; SURVIVAL; RISK;
   POPULATION; BRAIN
AB Metabolic and cognitive disorders are closely related. However, the molecular mechanism underlying this association is still elusive. Given the importance of energy metabolism in neuronal cells, AMP-activated protein kinase (AMPK), a master switch of energy metabolism, could be an independent factor affecting cognitive as well as metabolic functions. Therefore, we examined the relationship between the AMPK gamma 2 gene, the PRKAG2 -26C/T polymorphism and cognitive impairment or diabetes in 1609 subjects aged from 60 to 80. We performed multivariate logistic regression analyses with adjustment for age, gender, education, smoking, alcohol, depression, waist circumference, APOE e4, and stroke history. We found a significant association between the -26C/T polymorphism (CC vs. CT/TT) and cognitive impairment (OR, 1.6; 95% CI, 1.1-2.3). Moreover, this polymorphism (CC/CT vs. TT) was also related to the presence of diabetes (OR, 1.8; 95% CI, 1.2-2.8). Importantly, the relationship with cognitive impairment was still significant in non-diabetic individuals (OR, 1.6; 95% CI, 1.1-2.4). Further analyses with a subpopulation (n = 611) revealed that CC homozygotes relative to T-allele carriers had significantly better performances in verbal memory and attentional tasks. These findings collectively support a hypothesis that AMPK has a role not only in metabolic functioning but also in cognitive functioning in humans. Extended longitudinal study with a larger number of samples is warranted. (C) 2011 Elsevier Ltd. All rights reserved.
C1 [Hong, Chang Hyung] Ajou Univ, Dept Psychiat, Memory Impairment Ctr, Sch Med, Suwon 443749, Gyeonggi Do, South Korea.
   [Kim, Eosu; Namkoong, Kee; Oh, Byoung Hoon] Yonsei Univ, Dept Psychiat, Inst Behav Sci Med, Coll Med, Seoul 120752, South Korea.
   [Lee, Sung Hee] Yonsei Univ, Dept Pharmacol, Coll Med, Seoul 120752, South Korea.
   [Lee, Kang Soo] Kwandong Univ, Coll Med, Dept Psychiat, Myongji Hosp, Goyang 112270, South Korea.
   [Cheong, Hae-Kwan] Sungkyunkwan Univ, Dept Social & Prevent Med, Sch Med, Suwon 440746, South Korea.
C3 Ajou University; Yonsei University; Yonsei University Health System;
   Yonsei University; Yonsei University Health System; Catholic Kwandong
   University; Myongji Hospital; Sungkyunkwan University (SKKU)
RP Hong, CH (corresponding author), Ajou Univ, Dept Psychiat, Memory Impairment Ctr, Sch Med, San 5, Suwon 443749, Gyeonggi Do, South Korea.
EM antiaging@ajou.ac.kr; drobh@chol.com
RI LEE, Sunghee/HCH-4510-2022
OI NAMKOONG, KEE/0000-0003-1400-8057; Kim, Eosu/0000-0001-9472-9465;
   Cheong, Hae-Kwan/0000-0003-2758-9399
FU Yonsei University College of Medicine [6-2009-0171]; Ministry of Health
   a Welfare, Republic of Korea [A050079, A092039]
FX This study was supported by a Faculty Research Grant of Yonsei
   University College of Medicine for 2009 (6-2009-0171) and grants from
   the Ministry of Health a Welfare, Republic of Korea (A050079; A092039).
   These organizations had no further role in study design; in the
   collection, analysis and interpretation of data; in the writing of the
   report; and in the decision to submit the paper for publication.
CR [Anonymous], 1989, J. Korean Neuropsychiatr. Assoc
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NR 39
TC 24
Z9 24
U1 0
U2 10
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD MAR
PY 2012
VL 37
IS 3
BP 358
EP 365
DI 10.1016/j.psyneuen.2011.07.005
PG 8
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA 904QB
UT WOS:000301211900006
PM 21813245
DA 2025-06-11
ER

PT J
AU Woolf, EK
   Terwoord, JD
   Litwin, NS
   Vazquez, AR
   Lee, SY
   Ghanem, N
   Michell, KA
   Smith, BT
   Grabos, LE
   Ketelhut, NB
   Bachman, NP
   Smith, ME
   Le Sayec, M
   Rao, SET
   Gentile, CL
   Weir, TL
   Rodriguez-Mateos, A
   Seals, DR
   Dinenno, FA
   Johnson, SA
AF Woolf, Emily K.
   Terwoord, Janee D.
   Litwin, Nicole S.
   Vazquez, Allegra R.
   Lee, Sylvia Y.
   Ghanem, Nancy
   Michell, Kiri A.
   Smith, Brayden T.
   Grabos, Lauren E.
   Ketelhut, Nathaniel B.
   Bachman, Nate P.
   Smith, Meghan E.
   Le Sayec, Melanie
   Rao, Sangeeta
   Gentile, Christopher L.
   Weir, Tiffany L.
   Rodriguez-Mateos, Ana
   Seals, Douglas R.
   Dinenno, Frank A.
   Johnson, Sarah A.
TI Daily blueberry consumption for 12 weeks improves endothelial function
   in postmenopausal women with above-normal blood pressure through
   reductions in oxidative stress: a randomized controlled trial
SO FOOD & FUNCTION
LA English
DT Article
ID FLOW-MEDIATED DILATION; CARDIOLOGY/AMERICAN HEART ASSOCIATION;
   HIPPOPHAE-RHAMNOIDES L.; DOUBLE-BLIND; CARDIOVASCULAR-DISEASE; ARTERIAL
   STIFFNESS; METABOLIC SYNDROME; STAGE 1-HYPERTENSION; PHENOLIC
   METABOLITES; DEPENDENT DILATATION
AB Estrogen-deficient postmenopausal women have oxidative stress-mediated suppression of endothelial function that is exacerbated by high blood pressure. Previous research suggests blueberries may improve endothelial function through reductions in oxidative stress, while also exerting other cardiovascular benefits. The objective of this study was to examine the efficacy of blueberries to improve endothelial function and blood pressure in postmenopausal women with above-normal blood pressure, and to identify potential mechanisms for improvements in endothelial function. A randomized, double-blind, placebo-controlled, parallel-arm clinical trial was performed, where postmenopausal women aged 45-65 years with elevated blood pressure or stage 1-hypertension (total n = 43, endothelial function n = 32) consumed 22 g day(-1) of freeze-dried highbush blueberry powder or placebo powder for 12 weeks. Endothelial function was assessed at baseline and 12 weeks through ultrasound measurement of brachial artery flow-mediated dilation (FMD) normalized to shear rate area under the curve (FMD/SRAUC) before and after intravenous infusion of a supraphysiologic dose of ascorbic acid to evaluate whether FMD improvements were mediated by reduced oxidative stress. Hemodynamics, arterial stiffness, cardiometabolic blood biomarkers, and plasma (poly)phenol metabolites were assessed at baseline and 4, 8, and 12 weeks, and venous endothelial cell protein expression was assessed at baseline and 12 weeks. Absolute FMD/SRAUC was 96% higher following blueberry consumption compared to baseline (p < 0.05) but unchanged in the placebo group (p > 0.05), and changes from baseline to 12 weeks were greater in the blueberry group than placebo (+1.09 x 10(-4) +/- 4.12 x 10(-5)vs. +3.82 x 10(-6) +/- 1.59 x 10(-5), p < 0.03, respectively). The FMD/SRAUC response to ascorbic acid infusion was lower (p < 0.05) at 12 weeks compared to baseline in the blueberry group with no change in the placebo group (p > 0.05). The sum of plasma (poly)phenol metabolites increased at 4, 8, and 12 weeks in the blueberry group compared to baseline, and were higher than the placebo group (all p < 0.05). Increases in several plasma flavonoid and microbial metabolites were also noted. No major differences were found for blood pressure, arterial stiffness, blood biomarkers, or endothelial cell protein expression following blueberry consumption. These findings suggest daily consumption of freeze-dried blueberry powder for 12 weeks improves endothelial function through reduced oxidative stress in postmenopausal women with above-normal blood pressure. The clinical trial registry number is NCT03370991 (https://clinicaltrials.gov)
C1 [Woolf, Emily K.; Litwin, Nicole S.; Vazquez, Allegra R.; Lee, Sylvia Y.; Ghanem, Nancy; Michell, Kiri A.; Smith, Brayden T.; Grabos, Lauren E.; Gentile, Christopher L.; Weir, Tiffany L.; Johnson, Sarah A.] Colorado State Univ, Dept Food Sci & Human Nutr, Ft Collins, CO 80523 USA.
   [Terwoord, Janee D.; Ketelhut, Nathaniel B.; Bachman, Nate P.; Smith, Meghan E.; Dinenno, Frank A.] Colorado State Univ, Dept Hlth & Exercise Sci, Ft Collins, CO USA.
   [Rao, Sangeeta] Colorado State Univ, Dept Clin Sci, Ft Collins, CO USA.
   [Le Sayec, Melanie; Rodriguez-Mateos, Ana] Kings Coll London, Sch Life Course & Populat Sci, Dept Nutr Sci, London, England.
   [Seals, Douglas R.] Univ Colorado, Dept Integrat Physiol, Boulder, CO USA.
C3 Colorado State University System; Colorado State University Fort
   Collins; Colorado State University System; Colorado State University
   Fort Collins; Colorado State University System; Colorado State
   University Fort Collins; University of London; King's College London;
   University of Colorado System; University of Colorado Boulder
RP Johnson, SA (corresponding author), Colorado State Univ, Dept Food Sci & Human Nutr, Ft Collins, CO 80523 USA.
EM sarah.johnson@colostate.edu
RI Rao, Sangeeta/ABH-7983-2020; Johnson, Sarah/AAP-2170-2020;
   Rodriguez-Mateos, Ana/ABE-1560-2020
OI Ghanem, Nancy/0000-0003-3955-8645; Le Sayec,
   Melanie/0000-0001-9590-4165; Lee, Sylvia/0009-0002-3059-4412; Terwoord,
   Janee/0000-0003-1224-999X; Rodriguez-Mateos, Ana/0000-0003-3242-402X;
   Smith, Meghan/0000-0001-9320-2805
FU US Highbush Blueberry Council; USDA National Institute of Food and
   Agriculture [2020-67017-30833, 1021875]; College of Health and Human
   Sciences at Colorado State University
FX This research was funded by the US Highbush Blueberry Council, the USDA
   National Institute of Food and Agriculture [Grant No.
   2020-67017-30833/Project Accession No. 1021875], and the College of
   Health and Human Sciences at Colorado State University, and Kerry L.
   Hildreth at the University of Colorado Anschutz Medical Campus for their
   assistance in the study, as well as all of our volunteer participants.
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   Zhong Q, 2018, ANGIOLOGY, V69, P617, DOI 10.1177/0003319717742544
NR 104
TC 19
Z9 19
U1 1
U2 22
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PD MAR 20
PY 2023
VL 14
IS 6
BP 2621
EP 2641
DI 10.1039/d3fo00157a
EA FEB 2023
PG 21
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA 9X9TE
UT WOS:000939461200001
PM 36847333
OA hybrid
DA 2025-06-11
ER

PT J
AU Czubkowski, P
   Wierzbicka, A
   Pawlowska, J
   Jankowska, I
   Socha, P
AF Czubkowski, Piotr
   Wierzbicka, Aldona
   Pawlowska, Joanna
   Jankowska, Irena
   Socha, Piotr
TI Obesity, lipid profiles and oxidative stress in children after liver
   transplantation
SO ACTA BIOCHIMICA POLONICA
LA English
DT Article
DE reactive oxygen species; apolipoprotein; atherosclerosis; cholesterol
ID POSTTRANSPLANT METABOLIC SYNDROME; CYCLOSPORINE; DISEASE; RISK;
   IMMUNOSUPPRESSION; TACROLIMUS
AB Purpose. In adult liver transplant recipients, coronary artery disease and congestive heart failure are significant cause of morbidity and mortality. This may be attributed to the long-term immunosuppressive treatment, mostly with calcineurin inhibitors and steroids, which in long-term may be associated with hyperlipidemia, oxidative stress and cardiovascular complications. Since such data for children is sparse, the aim of this study was to assess the lipid and oxidative stress markers after pediatric liver transplantation (LTx). Method. We performed prospective analysis of 74 children, at the median age of 7.9 (2.8-11.6) years, 3.2 (1.2-4.3) years after LTx. We assessed the BMI Z-scores, cholesterol fractions (LDLc, HDLc, VLDLc), triglicerides, apolipoproteins (ApoAI, ApoB, ApoE), LCAT, insulin resistance by HOMA-IR and markers of oxidative stress and atherosclerosis: glutathione (GSH), glutathione peroxidase (GPx), asymmetrical dimethyl arginine (ADMA) and oxidized low-density lipoprotein (oxyLDL). At baseline, the results were compared with a healthy age-and-sex matched control group. After 3.1 +/- 0.3 year follow-up we repeated all investigations and compared them with the baseline results. RESULTS. At the baseline, we investigated 74 patients 3.2 (1.2-4.3) years after LTx, at the median age of 7.9 (2.8-11.6) years. The prevalence of overweight or obesity (BMI > 85th percentile) was 23% and was more common in girls (24% vs 20%). Fourteen patients had TCH > 200 mg%, 9 patients had LDLc > 130 mg% and TG were at normal levels in all patients. Compared to the controls, there were no significant differences in lipid profiles but we found decreased GSH (p<0.001) and GPx (p<0.001) which play role as an antioxidant defense. OS markers were higher in the study group: ADMA (p<0.001), and oxyLDL (p<0.0001). Insulin resistance by HOMA-IR was increased in the study group (p=0.0002) but fasting glucose remained within normal ranges in all patients. After 3.1-year follow-up, the BMI > 95th and > 85Th percentile was present in 8% and 14% respectively. ADMA and oxyLDL decreased, whilst GSH and GPx increased when compared to the baseline. There was also significant decrease in apoB and Lp(a). Conclusion. Children after LTx had normal lipid profiles when compared to controls, however there is a tendency for hypercholesterolemia and obesity, which may play a role in cardiovascular complications in the future. Some markers of oxidative stress were increased after LTx, however further investigations are required to establish its clinical significance.
C1 [Czubkowski, Piotr; Pawlowska, Joanna; Jankowska, Irena; Socha, Piotr] Childrens Mem Hlth Inst, Dept Gastroenterol Hepatol Nutr Disturbances & Pe, Warsaw, Poland.
   [Wierzbicka, Aldona] Childrens Mem Hlth Inst, Dept Biochem Radioimmunol & Expt Med, Warsaw, Poland.
C3 Children's Memorial Health Institute; Children's Memorial Health
   Institute
RP Wierzbicka, A (corresponding author), Childrens Mem Hlth Inst, Dept Biochem Radioimmunol & Expt Med, Warsaw, Poland.
EM aldona.wierzbicka@wp.pl
OI Pawlowska, Joanna/0000-0003-1154-8824; Wierzbicka-Rucinska,
   Aldona/0000-0002-9578-8894; Czubkowski, Piotr/0000-0002-0332-5703;
   Jankowska, Irena/0000-0001-6847-9570; Socha, Piotr/0000-0002-1621-464X
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   PAGLIA DE, 1967, J LAB CLIN MED, V70, P158
   Satapathy SK, 2011, LIVER TRANSPLANT, V17, P1, DOI 10.1002/lt.22222
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NR 19
TC 3
Z9 5
U1 0
U2 5
PU ACTA BIOCHIMICA POLONICA
PI WARSAW
PA PASTEURA 3, 02-093 WARSAW, POLAND
SN 0001-527X
EI 1734-154X
J9 ACTA BIOCHIM POL
JI Acta Biochim. Pol.
PY 2017
VL 64
IS 4
BP 661
EP 665
DI 10.18388/abp.2017_1623
PG 5
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA FQ2AJ
UT WOS:000418158700012
PM 29222858
OA gold
DA 2025-06-11
ER

PT J
AU Eller, NH
AF Eller, Nanna Hurwitz
TI Total power and high frequency components of heart rate variability and
   risk factors for atherosclerosis
SO AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL
LA English
DT Article
DE heart rate variability; coronary risk factors; stress
ID INTIMA MEDIA THICKNESS; PSYCHOSOCIAL FACTORS; METABOLIC SYNDROME;
   INSULIN-RESISTANCE; NERVOUS-SYSTEM; BLOOD-PRESSURE; STRESS SYSTEM;
   DISEASE; NEUROENDOCRINE; PROGRESSION
AB Introduction: Low heart rate variability, HRV, is associated with diabetic neuropathy and with ischemic heart disease, IHD. The time context points to diabetes preceding changes in HRV, while changes in HRV precede the development of atherosclerosis and IHD. The purpose of the study was to analyse the association between the physiological risk factors of IHD and HRV in a prospective design.
   Methods: In 1998 and 2002, data was gathered in a study concerning the risk factors for atherosclerosis. From among the participants it was possible to include 50 women and 24 men in a sub-study concerning HRV. Heart rate variability was measured partly during a clinical examination with exposure to a simple stress test, and partly during the first 4 h of sleep. The clinical examination, which lasted 45 min, resulted in 9, 5-minute HRV measurements, while the sleep period was divided into 2 periods of 2 h each, for which average HRV measurements were calculated. The associations between HRV and risk factors for IHD were analysed using the GLM, repeated measures method. As the dependent variables in the GLM analyses 11 levels (9 while awake and 2 while sleeping) of total power and high frequency variability, respectively, were used. The included risk factors were; body mass index, waist-hip ratio, systolic blood pressure, fibrinogen, cholesterol, HDL-cholesterol, HbA(1)c, testosterone, DHEAs, cortisol and catecholamines. Catecholamines were measured in urine and only in 1998. Cortisol was measured in both urine and saliva in 1998, but only in saliva in 2002. The results were adjusted according to the starting time of the measurements.
   Results: Among the women, waist-hip ratio and HbA(1)c were significantly and negatively associated with both TP and HE Stress hormones were not associated with HRV. Among the men, waist-hip ratio, HbA(1)c, and fibrinogen in 2002, and cortisol and noradrenaline in 1998 were significantly and negatively associated with TP and HF.
   Conclusion: The study showed gender differences in the observed associations. In both gender, waist ratio and HbA(1)c were negatively associated with TP and HE Furthermore, in the men, but not in the women, stress hormones in 1998, i.e. cortisol and noradrenaline, was negatively associated with TP and HF. The presented data give rise to discussion of the pathophysiology behind heart rate variability and ischemic heart disease, which may be different between women and men. (c) 2006 Elsevier B.V. All rights reserved.
RP Eller, NH (corresponding author), Hillerod Hosp, Clin Occupat Med, Helsevej 2-4, DK-3400 Hillerod, Denmark.
EM nael@fa.dk
RI Eller, Nanna/B-3981-2009
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NR 35
TC 23
Z9 26
U1 0
U2 6
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1566-0702
EI 1872-7484
J9 AUTON NEUROSCI-BASIC
JI Auton. Neurosci-Basic Clin.
PD JAN 30
PY 2007
VL 131
IS 1-2
BP 123
EP 130
DI 10.1016/j.autneu.2006.08.002
PG 8
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 129FF
UT WOS:000243713200016
PM 16987712
DA 2025-06-11
ER

PT J
AU Okely, AD
   Ghersi, D
   Loughran, SP
   Cliff, DP
   Shilton, T
   Jones, RA
   Stanley, RM
   Sherring, J
   Toms, N
   Eckermann, S
   Olds, TS
   Zhang, ZG
   Parrish, AM
   Kervin, L
   Downie, S
   Salmon, J
   Bannerman, C
   Needham, T
   Marshall, E
   Kaufman, J
   Brown, L
   Wille, J
   Wood, G
   Lubans, DR
   Biddle, SJH
   Pill, S
   Hargreaves, A
   Jonas, N
   Schranz, N
   Campbell, P
   Ingram, K
   Dean, H
   Verrender, A
   Ellis, Y
   Chong, KH
   Dumuid, D
   Katzmarzyk, PT
   Draper, CE
   Lewthwaite, H
   Tremblay, MS
AF Okely, Anthony D.
   Ghersi, Davina
   Loughran, Sarah P.
   Cliff, Dylan P.
   Shilton, Trevor
   Jones, Rachel A.
   Stanley, Rebecca M.
   Sherring, Julie
   Toms, Natalie
   Eckermann, Simon
   Olds, Timothy S.
   Zhang, Zhiguang
   Parrish, Anne-Maree
   Kervin, Lisa
   Downie, Sandra
   Salmon, Jo
   Bannerman, Clair
   Needham, Tamie
   Marshall, Elaine
   Kaufman, Jordy
   Brown, Layne
   Wille, Janecke
   Wood, Greg
   Lubans, David R.
   Biddle, Stuart J. H.
   Pill, Shane
   Hargreaves, Anthea
   Jonas, Natalie
   Schranz, Natasha
   Campbell, Perry
   Ingram, Karen
   Dean, Hayley
   Verrender, Adam
   Ellis, Yvonne
   Chong, Kar Hau
   Dumuid, Dorothea
   Katzmarzyk, Peter T.
   Draper, Catherine E.
   Lewthwaite, Hayley
   Tremblay, Mark S.
TI A collaborative approach to adopting/adapting guidelines. The Australian
   24-hour movement guidelines for children (5-12 years) and young people
   (13-17 years): An integration of physical activity, sedentary behaviour,
   and sleep
SO INTERNATIONAL JOURNAL OF BEHAVIORAL NUTRITION AND PHYSICAL ACTIVITY
LA English
DT Article
DE Methodology; GRADE-ADOLOPMENT; Public health recommendations; Guideline
   development
ID QUALITY-OF-LIFE; CARDIOMETABOLIC RISK-FACTORS; DECISION ETD FRAMEWORKS;
   MENTAL-HEALTH OUTCOMES; ON-TASK BEHAVIOR; SCREEN-TIME; PROSPECTIVE
   ASSOCIATIONS; CARDIORESPIRATORY FITNESS; LONGITUDINAL ASSOCIATIONS;
   DEPRESSIVE SYMPTOMS
AB Background In 2018, the Australian Government updated the Australian Physical Activity and Sedentary Behaviour Guidelines for Children and Young People. A requirement of this update was the incorporation of a 24-hour approach to movement, recognising the importance of adequate sleep. The purpose of this paper was to describe how the updated Australian 24-Hour Movement Guidelines for Children and Young People (5 to 17 years): an integration of physical activity, sedentary behaviour and sleep were developed and the outcomes from this process. Methods The GRADE-ADOLOPMENT approach was used to develop the guidelines. A Leadership Group was formed, who identified existing credible guidelines. The Canadian 24-Hour Movement Guidelines for Children and Youth best met the criteria established by the Leadership Group. These guidelines were evaluated based on the evidence in the GRADE tables, summaries of findings tables and recommendations from the Canadian Guidelines. We conducted updates to each of the Canadian systematic reviews. A Guideline Development Group reviewed, separately and in combination, the evidence for each behaviour. A choice was then made to adopt or adapt the Canadian recommendations for each behaviour or create de novo recommendations. We then conducted an online survey (n=237) along with three focus groups (n=11 in total) and 13 key informant interviews. Stakeholders used these to provide feedback on the draft guidelines. Results Based on the evidence from the Canadian systematic reviews and the updated systematic reviews in Australia, the Guideline Development Group agreed to adopt the Canadian recommendations and, apart from some minor changes to the wording of good practice statements, maintain the wording of the guidelines, preamble, and title of the Canadian Guidelines. The Australian Guidelines provide evidence-informed recommendations for a healthy day (24-hours), integrating physical activity, sedentary behaviour (including limits to screen time), and sleep for children (5-12 years) and young people (13-17 years). Conclusions To our knowledge, this is only the second time the GRADE-ADOLOPMENT approach has been used to develop movement behaviour guidelines. The judgments of the Australian Guideline Development Group did not differ sufficiently to change the directions and strength of the recommendations and as such, the Canadian Guidelines were adopted with only very minor alterations. This allowed the Australian Guidelines to be developed in a shorter time frame and at a lower cost. We recommend the GRADE-ADOLOPMENT approach, especially if a credible set of guidelines that was developed using the GRADE approach is available with all supporting materials. Other countries may consider this approach when developing and/or revising national movement guidelines.
C1 [Okely, Anthony D.; Loughran, Sarah P.; Cliff, Dylan P.; Jones, Rachel A.; Stanley, Rebecca M.; Sherring, Julie; Zhang, Zhiguang; Parrish, Anne-Maree; Kervin, Lisa; Brown, Layne; Verrender, Adam; Ellis, Yvonne; Chong, Kar Hau] Univ Wollongong, Sch Hlth & Soc, Fac Arts Social Sci & Humanities, Wollongong, NSW 2522, Australia.
   [Okely, Anthony D.; Loughran, Sarah P.; Cliff, Dylan P.; Jones, Rachel A.; Stanley, Rebecca M.] Illawarra Hlth & Med Res Inst, Wollongong, NSW, Australia.
   [Ghersi, Davina] Natl Hlth & Med Res Council, Res Policy & Translat, Canberra, ACT, Australia.
   [Ghersi, Davina] Univ Sydney, Sydney Med Sch, Natl Hlth & Med Res Council, Clin Trials Ctr, Sydney, NSW, Australia.
   [Shilton, Trevor] Natl Heart Fdn WA, 334 Rokeby Rd, Subiaco, WA, Australia.
   [Toms, Natalie; Downie, Sandra] Commonwealth Dept Hlth, Prevent Programs, Canberra, ACT, Australia.
   [Eckermann, Simon; Lewthwaite, Hayley] Univ Wollongong, Australian Hlth Serv Res Inst, Wollongong, NSW, Australia.
   [Olds, Timothy S.; Schranz, Natasha; Dumuid, Dorothea] Univ South Australia, Allied Hlth & Human Performance, Alliance Res Exercise Nutr & Act ARENA, Adelaide, SA, Australia.
   [Salmon, Jo] Deakin Univ, Inst Phys Act & Nutr IPAN, Melbourne, Vic, Australia.
   [Bannerman, Clair] Dept Educ, Canberra, ACT, Australia.
   [Needham, Tamie] Dept Hlth, Darwin, NT, Australia.
   [Marshall, Elaine] Dept Hlth, South Launceston, Tas, Australia.
   [Kaufman, Jordy] Swinburne Univ Technol, Melbourne, Vic, Australia.
   [Wille, Janecke] Federat Ethn Commun Council Australia FECCA, Canberra, ACT, Australia.
   [Wood, Greg] Australian Sports Commiss, Leederville, WA, Australia.
   [Lubans, David R.] Univ Newcastle, Sch Educ, Prior Res Ctr Phys Act & Nutr, Newcastle, NSW, Australia.
   [Biddle, Stuart J. H.] Univ Southern Queensland, Ctr Hlth Res, Toowoomba, Qld, Australia.
   [Pill, Shane] Australian Council Hlth Phys Educ & Recreat ACHPE, Wayville, Australia.
   [Pill, Shane] Flinders Univ S Australia, Adelaide, SA, Australia.
   [Hargreaves, Anthea] Cycling & Walking Australia New Zealand, Whanganui, New Zealand.
   [Jonas, Natalie] Australian Curriculum Assessment & Reporting Auth, Sydney, NSW, Australia.
   [Schranz, Natasha] Australia & Natl Heart Fdn, Act Hlth Kids Australia, Adelaide, SA, Australia.
   [Campbell, Perry] Australian Childrens Educ & Care Qual Author ACEC, Sydney, NSW, Australia.
   [Ingram, Karen; Dean, Hayley] NSW Educ Stand Author NESA, Sydney, NSW, Australia.
   [Katzmarzyk, Peter T.] Pennington Biomed Res Ctr, 6400 Perkins Rd, Baton Rouge, LA 70808 USA.
   [Draper, Catherine E.] Univ Witwatersrand, SAMRC Wits Dev Pathways Hlth, Johannesburg, South Africa.
   [Tremblay, Mark S.] Childrens Hosp Eastern Ontario, Res Inst, Hlth Act Living & Obes Res Grp, Ottawa, ON, Canada.
C3 University of Wollongong; Illawarra Health & Medical Research Institute;
   University of Wollongong; National Health & Medical Research Council
   (NHMRC) of Australia; University of Sydney; National Health & Medical
   Research Council (NHMRC) of Australia; National Heart Foundation of
   Australia; University of Wollongong; University of South Australia;
   Deakin University; Swinburne University of Technology; Australian Sports
   Commission; University of Newcastle; University of Southern Queensland;
   Flinders University South Australia; National Heart Foundation of
   Australia; Louisiana State University System; Louisiana State
   University; Pennington Biomedical Research Center; University of
   Witwatersrand; University of Ottawa; Children's Hospital of Eastern
   Ontario
RP Okely, AD (corresponding author), Univ Wollongong, Sch Hlth & Soc, Fac Arts Social Sci & Humanities, Wollongong, NSW 2522, Australia.
EM tokely@uow.edu.au
RI Katzmarzyk, Peter/N-1974-2017; Dumuid, Dot/HCI-5863-2022; Parrish,
   Anne-Maree/T-1000-2019; Lubans, David/G-7436-2013; Zhang,
   Zhiguang/ADQ-8859-2022; Chong, Kar Hau/GRS-2240-2022; Lewthwaite,
   Hayley/ABB-9414-2021; Draper, Catherine/GZN-1315-2022; Tremblay,
   Mark/ABI-5477-2020; Loughran, Sarah/AAA-9218-2021; Pill,
   Shane/IUN-6890-2023; Biddle, Stuart/AAE-9395-2019; Schranz,
   Natasha/F-4413-2013; Salmon, Jo/C-1226-2009; Loughran,
   Sarah/X-3317-2018; Okely, Anthony/R-1679-2018; Olds, Tim/A-1223-2008;
   Stanley, Rebecca/P-6720-2016; Lewthwaite, Hayley/B-6989-2017
OI Zhang, Zhiguang/0000-0001-6873-7410; Verrender,
   Adam/0000-0002-1447-339X; Kervin, Lisa/0000-0002-5433-7587; Pill,
   Shane/0000-0003-3970-6724; Loughran, Sarah/0000-0002-3438-3914; Okely,
   Anthony/0000-0002-1626-8170; Dumuid, Dorothea/0000-0003-3057-0963;
   Chong, Kar Hau/0000-0002-3893-4306; Olds, Tim/0000-0001-6894-5519;
   Stanley, Rebecca/0000-0001-7007-3406; Lewthwaite,
   Hayley/0000-0002-5212-2937
FU Commonwealth of Australia, Department of Health
FX The development of these Guidelines was funded by the Commonwealth of
   Australia, Department of Health. The funding body had no role in the
   design of the study and collection, analysis, and interpretation of data
   or in the writing of the manuscript. The publication costs were paid for
   by The Faculty of Social Sciences at the University of Wollongong and
   the Australian Government Department of Health.
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NR 133
TC 66
Z9 70
U1 11
U2 63
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1479-5868
J9 INT J BEHAV NUTR PHY
JI Int. J. Behav. Nutr. Phys. Act.
PD JAN 6
PY 2022
VL 19
IS 1
AR 2
DI 10.1186/s12966-021-01236-2
PG 21
WC Nutrition & Dietetics; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nutrition & Dietetics; Physiology
GA YC8PI
UT WOS:000739947500002
PM 34991606
OA Green Published, gold
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Salameh, TS
   Mortell, WG
   Logsdon, AF
   Butterfield, DA
   Banks, WA
AF Salameh, Therese S.
   Mortell, William G.
   Logsdon, Aric F.
   Butterfield, D. Allan
   Banks, William A.
TI Disruption of the hippocampal and hypothalamic blood-brain barrier in a
   diet-induced obese model of type II diabetes: prevention and treatment
   by the mitochondrial carbonic anhydrase inhibitor, topiramate
SO FLUIDS AND BARRIERS OF THE CNS
LA English
DT Article
DE Type II diabetes; Blood-brain barrier; Blood-retinal barrier;
   Hypothalamus; Hippocampus; Topiramate
ID HIGH-FAT DIET; MILD COGNITIVE IMPAIRMENT; MOUSE CEREBRAL PERICYTES;
   HIGH-ENERGY DIET; OXIDATIVE STRESS; BODY-WEIGHT; PHARMACOLOGICAL
   INHIBITION; ADIPOSE-TISSUE; RATS; HYPERGLYCEMIA
AB BackgroundType II diabetes is a vascular risk factor for cognitive impairment and increased risk of dementia. Disruption of the blood-retinal barrier (BRB) and blood-brain barrier (BBB) are hallmarks of subsequent retinal edema and central nervous system dysfunction. However, the mechanisms by which diet or metabolic syndrome induces dysfunction are not understood. A proposed mechanism is an increase in reactive oxygen species (ROS) and oxidative stress. Inhibition of mitochondrial carbonic anhydrase (mCA) decreases ROS and oxidative stress. In this study, topiramate, a mCA inhibitor, was examined for its ability to protect the BRB and BBB in diet-induced obese type II diabetic mice.MethodsBBB and BRB permeability were assessed using C-14-sucrose and Tc-99m-albumin in CD-1 mice fed a low-fat (control) or a high-fat diet. Topiramate administration was compared to saline controls in both preventative and efficacy arms examining BRB and BBB disruption. Body weight and blood glucose were measured weekly and body composition was assessed using EchoMRI. Metabolic activity was measured using a comprehensive laboratory animal monitoring system. Brain tissues collected from the mice were assessed for changes in oxidative stress and tight junction proteins.ResultsHigh-fat feeding caused increased entry of C-14-sucrose and Tc-99m-albumin into the brains of diet-induced obese type II diabetic mice. Increased permeability to C-14-sucrose was observed in the hypothalamus and hippocampus, and attenuated by topiramate treatment, while increased permeability to Tc-99m-albumin occurred in the whole brain and was also attenuated by topiramate. Treatment with topiramate decreased measures of oxidative stress and increased expression of the tight junction proteins ZO-1 and claudin-12. In the retina, we observed increased entry of Tc-99m-albumin simultaneously with increased entry into the whole brain during the preventative arm. This occurred prior to increased entry to the retina for C-14-sucrose which occurred during the efficacy arm. Treatment with topiramate had no effect on the retina.ConclusionsBlood-brain barrier and blood-retinal barrier dysfunction were examined in a mouse model of diet-induced obese type II diabetes. These studies demonstrate that there are spatial and temporal differences in C-14-sucrose and Tc-99m-albumin permeability in the brain and retina of diet-induced obese type II diabetic mice. Topiramate, a mitochondrial carbonic anhydrase inhibitor, is efficacious at both preventing and treating BBB disruption in this diet-induced obese type II diabetic mouse model.
C1 [Salameh, Therese S.; Mortell, William G.; Logsdon, Aric F.; Banks, William A.] Vet Affairs Puget Sound Hlth Care Syst, Ctr Geriatr Res Educ & Clin, 1660 S Columbian Way,810A Bldg 1, Seattle, WA 98108 USA.
   [Salameh, Therese S.; Logsdon, Aric F.; Banks, William A.] Univ Washington, Dept Med, Div Gerontol & Geriatr Med, Seattle, WA USA.
   [Butterfield, D. Allan] Univ Kentucky, Dept Chem, Lexington, KY 40506 USA.
   [Butterfield, D. Allan] Univ Kentucky, Sanders Brown Ctr Aging, Lexington, KY 40536 USA.
C3 US Department of Veterans Affairs; Veterans Health Administration (VHA);
   Vet Affairs Puget Sound Health Care System; Geriatric Research Education
   & Clinical Center; University of Washington; University of Washington
   Seattle; University of Kentucky; University of Kentucky
RP Banks, WA (corresponding author), Vet Affairs Puget Sound Hlth Care Syst, Ctr Geriatr Res Educ & Clin, 1660 S Columbian Way,810A Bldg 1, Seattle, WA 98108 USA.
EM tsalameh@uw.edu; wabanks1@uw.edu
RI Banks, William/K-1330-2017
FU National Institutes of Health National Institute on Neurological
   Disorders and Stroke [R21 NS093368-01A1]; National Institute on Aging
   [R01 AG046619, T32 AG052354]
FX This work was supported by the National Institutes of Health National
   Institute on Neurological Disorders and Stroke (Grant R21 NS093368-01A1)
   and National Institute on Aging (Grant R01 AG046619 and T32 AG052354).
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NR 68
TC 67
Z9 74
U1 0
U2 10
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 2045-8118
J9 FLUIDS BARRIERS CNS
JI Fluids Barriers CNS
PD JAN 8
PY 2019
VL 16
AR 1
DI 10.1186/s12987-018-0121-6
PG 17
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA HG6ZT
UT WOS:000455138000001
PM 30616618
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Pickup, JC
   Chusney, GD
   Mattock, MB
AF Pickup, JC
   Chusney, GD
   Mattock, MB
TI The innate immune response and type 2 diabetes: evidence that leptin is
   associated with a stress-related (acute-phase) reaction
SO CLINICAL ENDOCRINOLOGY
LA English
DT Article
ID SERUM SIALIC-ACID; INSULIN-RESISTANCE; METABOLIC SYNDROME; NIDDM;
   CYTOKINES; DISEASE; HUMANS; GENE; GLUCOCORTICOIDS; INTERLEUKIN-6
AB OBJECTIVE Leptin is produced by adipose tissue and controls food intake and body weight. Although blood levels of leptin reflect energy stores, cytokines also stimulate leptin production from fat. Because we have proposed that type 2 diabetes mellitus is associated with a cytokine-mediated acute-phase or stress response, part of the innate immune system, we sought evidence that leptin is increased in type 2 diabetes partly as a stress response, independently of obesity and sex.
   DESIGN We selected two groups of type 2 diabetic patients with either a low acute-phase response (< 2.30 mmol/l serum concentration of the acute-phase marker sialic acid) or high response (> 2.30 mmol/l sialic acid), but pair-matched for body mass index (BMI) and sex.
   PATIENTS Twenty type 2 diabetic subjects (11 male, 9 female) in each group, whose body mass index (BMI) and age were comparable (mean +/- SD: 28.8 +/- 3.8 vs. 28.9 +/- 3.8 kg/m(2), and 60.7 +/- 8.9 vs. 61.9 +/- 12.3 years, low vs. high acute-phase responders, respectively). The glycaemic control was also similar in each group (glycated haemoglobin: 9.1 +/- 2.2 vs. 8.9 +/- 1.9%).
   MEASUREMENTS Serum concentrations of sialic acid, leptin, interleukin-6 (IL-6) (the major cytokine mediator of the acute-phase response) and cortisol were assayed in fasting venous blood samples from patients and the results compared.
   RESULTS Serum leptin concentration was increased in the high compared to the low acute-phase group (median 13.2 (range 3.6-55) vs. 8.1 (2.0-22.5) mu g/l, P = 0.004). IL-6 and cortisol concentrations were also higher in the high-stress group (1.9 (1.0-6.4) vs. 1.4 (0.4-7.5) ng/l, P = 0.02; and 409 (180-875) vs. 290 (157-705) nmol/l, P = 0.02, respectively). Leptin was strongly correlated with BMI (r = 0.61, P < 0.001), but also with sialic acid (r = 0.40, P = 0.01) and IL-6 (r = 0.38, P = 0.04).
   CONCLUSIONS Serum leptin concentrations in type 2 diabetes are partly related to an acute-phase or stress response, independent of BMI and sex. The association of hyperleptinaemia with elevated serum cortisol provides a mechanism for leptin resistance in type 2 diabetes (glucocorticoids inhibit the central action of leptin). This study provides further support for the theory that type 2 diabetes is asociated with chronic innate immune activation.
C1 Guys Hosp, Guys Kings & St Thomass Hosp, Sch Med, Dept Chem Pathol, London SE1 9RT, England.
C3 University of London; King's College London; Guy's & St Thomas' NHS
   Foundation Trust
RP Pickup, JC (corresponding author), Guys Hosp, Guys Kings & St Thomass Hosp, Sch Med, Dept Chem Pathol, London SE1 9RT, England.
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NR 31
TC 40
Z9 44
U1 0
U2 5
PU BLACKWELL SCIENCE LTD
PI OXFORD
PA P O BOX 88, OSNEY MEAD, OXFORD OX2 0NE, OXON, ENGLAND
SN 0300-0664
J9 CLIN ENDOCRINOL
JI Clin. Endocrinol.
PD JAN
PY 2000
VL 52
IS 1
BP 107
EP 112
DI 10.1046/j.1365-2265.2000.00921.x
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 287TK
UT WOS:000085522400016
PM 10651761
DA 2025-06-11
ER

PT J
AU Rahmani, E
   Samimi, M
   Ebrahimi, FA
   Foroozanfard, F
   Ahmadi, S
   Rahimi, M
   Jamilian, M
   Aghadavod, E
   Bahmani, F
   Taghizadeh, M
   Memarzadeh, MR
   Asemi, Z
AF Rahmani, Elham
   Samimi, Mansooreh
   Ebrahimi, Faraneh Afshar
   Foroozanfard, Fatemeh
   Ahmadi, Shahnaz
   Rahimi, Maryam
   Jamilian, Mehri
   Aghadavod, Esmat
   Bahmani, Fereshteh
   Taghizadeh, Mohsen
   Memarzadeh, Mohammad Reza
   Asemi, Zatollah
TI The effects of omega-3 fatty acids and vitamin E co-supplementation on
   gene expression of lipoprotein(a) and oxidized low-density lipoprotein,
   lipid profiles and biomarkers of oxidative stress in patients with
   polycystic ovary syndrome
SO MOLECULAR AND CELLULAR ENDOCRINOLOGY
LA English
DT Article
DE Omega fatty acids and vitamin E; Gene expression; Lipid profiles;
   Oxidative stress; Polycystic ovary syndrome
ID CONTROLLED CLINICAL-TRIAL; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   PROTEIN-LEVELS; HEMODIALYSIS-PATIENTS; SERUM ADIPONECTIN;
   DIABETES-MELLITUS; ADIPOSE-TISSUE; FATTY-ACIDS; WOMEN
AB This study was conducted to determine the effects of omega-3 fatty acids and vitamin E co-supplementation on gene expression of lipoprotein(a) (Lp[a]) and oxidized low-density lipoprotein (Ox-LDL), lipid profiles and biomarkers of oxidative stress in women with polycystic ovary syndrome (PCOS). This randomized double-blind, placebo-controlled trial was done on 68 women diagnosed with PCOS according to the Rotterdam criteria aged 18-40 years old. Participants were randomly assigned into two groups to receive either 1000 mg omega-3 fatty acids from flaxseed oil containing 400 mg alpha-Linolenic acid plus 400 HJ vitamin E supplements (n = 34) or placebo (n = 34) for 12 weeks. Lp(a) and Ox-LDL mRNA levels were quantified in peripheral blood mononuclear cells of PCOS women with RT-PCR method. Lipid profiles and biomarkers of oxidative stress were quantified at the beginning of the study and after 12-week intervention. Quantitative results of RT-PCR demonstrated that compared with the placebo, omega-3 fatty acids and vitamin E co-supplementation downregulated expressed levels of Lp(a) mRNA (P < 0.001) and Ox-LDL mRNA (P < 0.001) in peripheral blood mononuclear cells of women with PCOS. In addition, compared to the placebo group, omega-3 fatty acids and vitamin E co-supplementation resulted in a significant decrease in serum triglycerides (-22.1 +/- 22.3 vs. +7.7 +/- 23.6 mg/dL, P < 0.001), VLDL- (-4.4 +/- 4.5 vs. +1.5 +/- 4.7 mg/dL, P < 0.001), total- (-20.3 +/- 16.6 vs. +12.2 +/- 26.1 mg/dL, P < 0.001), LDL- (-16.7 +/- 15.3 vs. +11.9 +/- 26.1 mg/dL, P < 0.001) and total-/HDL-cholesterol (-0.5 +/- 0.6 vs. +0.4 +/- 0.8, P < 0.001). There were a significant increase in plasma total antioxidant capacity (+89.4 +/- 108.9 vs. +5.9 +/- 116.2 mmol/L, P = 0.003) and a significant decrease in malondialdehyde levels (-0.3 +/- 0.4 vs. -0.008 +/- 0.6 mu mol/L, P = 0.01) by combined omega-3 fatty acids and vitamin E intake compared with the placebo group. Overall, omega-3 fatty acids and vitamin E co-supplementation for 12 weeks in PCOS women significantly improved gene expression of Lp(a) and OxLDL, lipid profiles and biomarkers of oxidative stress. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
C1 [Rahmani, Elham; Ahmadi, Shahnaz] Bushehr Univ Med Sci, Sch Med, Dept Gynecol & Obstet, Bushehr, Iran.
   [Samimi, Mansooreh; Ebrahimi, Faraneh Afshar; Foroozanfard, Fatemeh] Kashan Univ Med Sci, Sch Med, Dept Gynecol & Obstet, Kashan, Iran.
   [Ahmadi, Shahnaz; Rahimi, Maryam] Iran Univ Med Sci, Sch Med, Dept Gynecol & Obstet, Tehran, Iran.
   [Jamilian, Mehri] Arak Univ Med Sci, Sch Med, Dept Gynecol & Obstet, Endocrinol & Metab Res Ctr, Arak, Iran.
   [Aghadavod, Esmat; Bahmani, Fereshteh; Taghizadeh, Mohsen; Asemi, Zatollah] Kashan Univ Med Sci, Res Ctr Biochem & Nutr Metab Dis, Kashan, Iran.
   [Memarzadeh, Mohammad Reza] Barij Med Plants Res Ctr, Kashan, Iran.
C3 Iran University of Medical Sciences
RP Asemi, Z (corresponding author), Kashan Univ Med Sci, Res Ctr Biochem & Nutr Metab Dis, Kashan, Iran.
EM asemi_r@yahoo.com
RI Ebrahimi, Fatemeh/JEZ-7438-2023; Rahmani, Elham/S-4222-2017;
   Foroozanfard, Fatemeh/G-2771-2017; jamilian, mehri/F-7559-2016; asemi,
   zatollah/J-2677-2018; Samimi, Mansoreh/V-3813-2017; Aghadavod,
   Esmat/I-7736-2017; Bahmani, Fereshteh/G-7641-2017; Mohsen,
   Taghizadeh/D-7784-2017; Asemi, Zatollah/G-7393-2017
OI Rahmani, Elham/0000-0001-8392-7685; Samimi,
   Mansoreh/0000-0002-5809-3612; ahmadi, shahnaz/0000-0002-2136-4474;
   Aghadavod, Esmat/0000-0001-9456-9238; Bahmani,
   Fereshteh/0000-0003-0683-3153; memarzadeh, mohammad
   reza/0000-0001-5965-9182; Mohsen, Taghizadeh/0000-0001-6526-5497; Asemi,
   Zatollah/0000-0001-5265-4792
FU KUMS; BPUMS
FX The current study was founded by a grant from the Vice-chancellor for
   Research, KUMS and BPUMS, and Iran. The authors would like to thank the
   staff of Naghavi Clinic (Kashan, Iran) for their assistance on this
   project.
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NR 57
TC 58
Z9 60
U1 1
U2 30
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0303-7207
J9 MOL CELL ENDOCRINOL
JI Mol. Cell. Endocrinol.
PD JAN 5
PY 2017
VL 439
IS C
BP 247
EP 255
DI 10.1016/j.mce.2016.09.008
PG 9
WC Cell Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Endocrinology & Metabolism
GA EH3CX
UT WOS:000391647800026
PM 27619403
DA 2025-06-11
ER

PT J
AU Heininger, K
AF Heininger, K
TI Aging is a deprivation syndrome driven by a germ-soma conflict
SO AGEING RESEARCH REVIEWS
LA English
DT Review
DE aging; longevity; deprivation syndrome; evolution; reproduction; gonadal
   hormones; stress resistance; metabolism; oxidative stress; mitochondria;
   caloric restriction; hormesis; metabolic syndrome; mutagenesis;
   glucocorticosteroids; insulin; leptin; NPY; differentiation; apoptosis;
   cancer; Alzheimer's disease; diabetes mellitus; glucose-fatty acid
   cycle; germ-soma conflict theory
ID GONADOTROPIN-RELEASING-HORMONE; PROGRAMMED CELL-DEATH; MITOCHONDRIAL-DNA
   MUTATIONS; LIFE-SPAN EXTENSION; HYPOTHALAMIC ARCUATE NUCLEUS;
   PITUITARY-GONADAL AXIS; CENTRAL-NERVOUS-SYSTEM; CYTOCHROME-C-OXIDASE;
   RAT SKELETAL-MUSCLE; AGE-RELATED-CHANGES
AB Evolution through natural selection can be described as driven by a perpetual conflict of individuals competing for limited resources. Recently, I postulated that the shortage of resources godfathered the evolutionary achievements of the differentiation-apoptosis programming [Rev. Neurosci. 12 (2001) 217]. Unicellular deprivation-induced differentiation into germ cell-like spores can be regarded as the archaic reproduction events which were fueled by the remains of the fratricided cells of the apoptotic fruiting body. Evidence has been accumulated suggesting that conserved through the ages as the evolutionary legacy of the germ-soma conflict, the somatic loss of immortality during the ontogenetic segregation of primordial germ cells recapitulates the archaic fate of the fruiting body. In this heritage, somatic death is a germ cell-triggered event and has been established as evolutionary-fixed default state following asymmetric reproduction in a world of finite resources. Aging, on the other hand, is the stress resistance-dependent phenotype of the somatic resilience that counteracts the germ cell-inflicted death pathway. Thus, aging is a survival response and, in contrast to current beliefs, is antagonistically linked to death that is not imposed by group selection but enforced upon the soma by the selfish genes of the "enemy within". Environmental conditions shape the trade-off solutions as compromise between the conflicting germ-soma interests. Mechanistically, the neuroendocrine system, particularly those components that control energy balance, reproduction and stress responses, orchestrate these events. The reproductive phase is a self-limited process that moulds onset and progress of senescence with germ cell-dependent factors, e.g. gonadal hormones. These degenerate the regulatory pacemakers of the pineal-hypothalamic-pituitary network and its peripheral, e.g. thymic, gonadal and adrenal targets thereby eroding the trophic milieu. The ensuing cellular metabolic stress engenders adaptive adjustments of the glucose-fatty acid cycle, responses that are adequate and thus fitness-boosting under fuel shortage (e.g. during caloric restriction) but become detrimental under fuel abundance. In a Janus-faced capacity, the cellular stress response apparatus expresses both tolerogenic and mutagenic features of the social and asocial deprivation responses [Rev. Neurosci. 12 (2001) 217]. Mediated by the derangement of the energy-Ca2+-redox homeostatic triangle, a mosaic of dedifferentiation/apoptosis and mutagenic responses actuates the gradual exhaustion of functional reserves and eventually results in a multitude of aging-related diseases. This scenario reconciles programmed and stochastic features of aging and resolves the major inconsistencies of current theories by linking ultimate and proximate causes of aging. Reproduction, differentiation, apoptosis, stress response and metabolism are merged into a coherent regulatory network that stages aging as a naturally selected, germ cell-triggered and reproductive phase-modulated deprivation response. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
C1 Univ Dusseldorf, Dept Neurol, D-4000 Dusseldorf, Germany.
C3 Heinrich Heine University Dusseldorf
RP Univ Dusseldorf, Dept Neurol, D-4000 Dusseldorf, Germany.
EM kurt.heininger@web.de
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NR 584
TC 24
Z9 28
U1 0
U2 22
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 1568-1637
EI 1872-9649
J9 AGEING RES REV
JI Ageing Res. Rev.
PD JUN
PY 2002
VL 1
IS 3
BP 481
EP 536
AR PII S1568-1637(02)00015-6
DI 10.1016/S1568-1637(02)00015-6
PG 56
WC Cell Biology; Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Geriatrics & Gerontology
GA 603AP
UT WOS:000178536900012
PM 12067599
DA 2025-06-11
ER

PT J
AU Khattab, BA
   Hammad, MO
   Eldken, ZH
   Hellal, D
   Mohamed, SZ
   Sakr, NH
AF Khattab, Basma Adel
   Hammad, Maha Osman
   Eldken, Zienab Helmy
   Hellal, Doaa
   Mohamed, Sherin Zohdy
   Sakr, Noha Hammad
TI Impact of intermittent fasting versus vitamin D on high fat
   fructose-induced pancreatic steatosis: possible role of aquaporins
SO MOLECULAR MEDICINE
LA English
DT Article
DE Pancreatic steatosis; Aquaporin; NLRP3; Fasting; Vitamin D
ID METABOLIC SYNDROME; INSULIN SENSITIVITY; NLRP3 INFLAMMASOME;
   GENE-EXPRESSION; RATS; PCR
AB BackgroundThe molecular basis of pancreatic steatosis is not entirely known. Aquaporins (AQPs) are integral membrane proteins involved in a variety of pancreatic functions. Given the little data regarding the potential role of aquaporins in the pathogenesis of pancreatic steatosis, this study was designed to assess the role of aquaporins and the NLRP3-inflammasome in the rat model of high-fat fructose diet (HFFD) and to investigate the impact of vitamin D supplementation and alternate day fasting (ADF) in ameliorating HFFD-induced pancreatic steatosis.MethodTwenty-four Sprague-Dawley male rats were divided equally into 4 groups. Group I (control group), Group II (HFFD group), Group III (HFFD + ADF group), and Group IV (HFFD + vitamin D group). By the end of the experiment, fasting blood samples were collected for determination of blood glucose, serum insulin, lipid profile, and insulin resistance. Oxidative stress biomarkers (malondialdehyde and reduced glutathione), inflammatory markers (interleukin-1 beta and TNF-alpha), and expression of aquaporins (AQP-1, AQP-3, and AQP-7) genes were evaluated in pancreatic tissues. Histopathological examination of the pancreas and immunohistochemistry of the NLRP3-infammasome and AQP-7 were performed.ResultsThe HFFD group exhibited pancreatic steatosis with a significant elevation in the levels of blood sugar, serum insulin, insulin resistance, lipid profile, oxidative stress, inflammatory markers, and AQP-3 and AQP-7 mRNA expressions. Regarding histopathology, there were pale vacuolated-stained cytoplasm in acinar pancreatic cells and increased immunoreactivity for AQP-7 and NLRP3-inflammasome. All these parameters improved with ADF and vitamin D supplementation, with more favorable effects for ADF.ConclusionADF and vitamin D treatment ameliorated the effect of the high-fat fructose diet at both levels of the biochemical and histopathological examinations.
C1 [Khattab, Basma Adel] Mansoura Univ, Fac Med, Dept Anat & Embryol, Mansoura, Egypt.
   [Hammad, Maha Osman] Mansoura Univ, Fac Med, Dept Med Biochem & Mol Biol, Mansoura 35516, Al Daqhalia, Egypt.
   [Eldken, Zienab Helmy] Mansoura Univ, Fac Med, Dept Med Physiol, Mansoura, Egypt.
   [Hellal, Doaa] Mansoura Univ, Fac Med, Dept Clin Pharmacol, Mansoura, Egypt.
   [Hellal, Doaa] Univ Hail, Coll Med, Dept Pharmacol, Hail, Saudi Arabia.
   [Mohamed, Sherin Zohdy] Horus Univ, Fac Med, Dept Internal Med, New Damietta, Egypt.
   [Sakr, Noha Hammad] Kafrelsheikh Univ, Fac Med, Dept Anat & Embryol, KafrElsheikh, Egypt.
C3 Egyptian Knowledge Bank (EKB); Mansoura University; Egyptian Knowledge
   Bank (EKB); Mansoura University; Egyptian Knowledge Bank (EKB); Mansoura
   University; Egyptian Knowledge Bank (EKB); Mansoura University;
   University Ha'il; Egyptian Knowledge Bank (EKB); Kafrelsheikh University
RP Hammad, MO (corresponding author), Mansoura Univ, Fac Med, Dept Med Biochem & Mol Biol, Mansoura 35516, Al Daqhalia, Egypt.
EM maha_osman@mans.edu.eg
RI Hammad, Maha/D-9388-2019
OI Hammad, Maha/0000-0002-7136-4499
FU Science, Technology & Innovation Funding Authority (STDF); Egyptian
   Knowledge Bank (EKB)
FX Open access funding provided by The Science, Technology & Innovation
   Funding Authority (STDF) in cooperation with The Egyptian Knowledge Bank
   (EKB).
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NR 65
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1076-1551
EI 1528-3658
J9 MOL MED
JI Mol. Med.
PD MAY 26
PY 2025
VL 31
IS 1
AR 207
DI 10.1186/s10020-025-01239-w
PG 16
WC Biochemistry & Molecular Biology; Cell Biology; Medicine, Research &
   Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology; Research & Experimental
   Medicine
GA 2ZM5K
UT WOS:001495018300001
PM 40419958
DA 2025-06-11
ER

PT J
AU Jackson, EK
   Tofovic, SP
   Chen, YY
   Birder, LA
AF Jackson, Edwin K.
   Tofovic, Stevan P.
   Chen, Yuanyuan
   Birder, Lori A.
TI 8-Aminopurines in the Cardiovascular and Renal Systems and Beyond
SO HYPERTENSION
LA English
DT Review
DE 8-aminoguanine; 8-aminoguanosine; hypertension; purine-nucleoside
   phosphorylase; stroke
ID PURINE NUCLEOSIDE PHOSPHORYLASE; ADENOSINE RECEPTOR PROTECTS;
   SALT-SENSITIVE HYPERTENSION; OXIDATIVE STRESS; MEDULLARY CIRCULATION;
   PLATELET ACTIVATION; SODIUM-EXCRETION; NITRATED DNA; RAC1 GTPASE;
   INOSINE
AB Screening of compounds comprising 8-substituted guanine revealed that 8-aminoguanosine and 8-aminoguanine cause diuresis/natriuresis/glucosuria, yet decrease potassium excretion. Subsequent investigations demonstrated that 8-aminoguanosine's effects are mediated by its metabolite 8-aminoguanine. The mechanism by which 8-aminoguanine causes diuresis/natriuresis/glucosuria involves inhibition of PNPase (purine nucleoside phosphorylase), which increases renal interstitial inosine levels. Additional evidence suggests that inosine, via indirect or direct adenosine A2B receptor activation, increases renal medullary blood flow which enhances renal excretory function. Likely, 8-aminoguanine has pleiotropic actions that also alter renal excretory function. Indeed, the antikaliuretic effects of 8-aminoguanine are independent of PNPase inhibition. 8-Aminoguanine is an endogenous molecule; nitrosative stress leads to production of biomolecules containing 8-nitroguanine moieties. Degradation of these biomolecules releases 8-nitroguanosine and 8-nitro-2 '-deoxyguanosine which are converted to 8-aminoguanine. Also, guanosine and guanine per se may contribute to 8-aminoguanine formation. 8-Aminoinosine, 8-aminohypoxanthine, and 8-aminoxanthine likewise induce diuresis/natriuresis/glucosuria, yet do not reduce potassium excretion. Thus, there are several pharmacologically active 8-aminopurines with nuanced effects on renal excretory function. Chronic treatment with 8-aminoguanine attenuates hypertension in deoxycorticosterone/salt rats, prevents strokes, and increases lifespan in Dahl salt-sensitive rats on a high salt diet and attenuates the metabolic syndrome in rats; 8-aminoguanosine retards progression of pulmonary hypertension in rats and anemia and organ damage in sickle cell mice. 8-Aminoguanine reverses age-associated lower urinary tract dysfunction and retinal degeneration. 8-Aminopurines represent a new class of agents (and potentially endogenous factors) that have beneficial effects on the cardiovascular system and kidneys and may turn back the clock in age-associated diseases.
C1 [Jackson, Edwin K.; Tofovic, Stevan P.; Chen, Yuanyuan; Birder, Lori A.] Univ Pittsburgh, Sch Med, Dept Pharmacol & Chem Biol, 100 Technol Dr,Room 514, Pittsburgh, PA 15219 USA.
   [Jackson, Edwin K.; Tofovic, Stevan P.; Birder, Lori A.] Univ Pittsburgh, Sch Med, Dept Med, Pittsburgh, PA 15219 USA.
   [Chen, Yuanyuan] Univ Pittsburgh, Sch Med, Dept Ophthalmol, Pittsburgh, PA 15219 USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE); University
   of Pittsburgh; Pennsylvania Commonwealth System of Higher Education
   (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of
   Higher Education (PCSHE); University of Pittsburgh
RP Jackson, EK (corresponding author), Univ Pittsburgh, Sch Med, Dept Pharmacol & Chem Biol, 100 Technol Dr,Room 514, Pittsburgh, PA 15219 USA.
EM edj@pitt.edu
RI Chen, Yuanyuan/JZE-5826-2024
OI Chen, Yuanyuan/0000-0001-9625-1610
FU National Institutes of Health [HL109002, DK135076, AG056944]; Richard
   King Mellon Foundation
FX This work was supported by grants from the National Institutes of Health
   (HL109002, DK135076, AG056944) and by the Richard King Mellon
   Foundation.
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NR 90
TC 2
Z9 2
U1 0
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0194-911X
EI 1524-4563
J9 HYPERTENSION
JI Hypertension
PD NOV
PY 2023
VL 80
IS 11
BP 2265
EP 2279
DI 10.1161/HYPERTENSIONAHA.123.20582
PG 15
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA U5MI2
UT WOS:001085239100005
PM 37503660
DA 2025-06-11
ER

PT J
AU Maiti, R
   Mohanty, RR
   Dey, A
   Maji, S
   Padhan, M
   Mishra, A
AF Maiti, Rituparna
   Mohanty, Rashmi Ranjan
   Dey, Anupam
   Maji, Shampa
   Padhan, Milan
   Mishra, Archana
TI Effect of Virgin Coconut Oil (VCO) on Cardiometabolic Parameters in
   Patients with Dyslipidemia: A Randomized, Add-on Placebo-Controlled
   Clinical Trial
SO JOURNAL OF THE AMERICAN NUTRITION ASSOCIATION
LA English
DT Article
DE Dyslipidemia; atorvastatin; virgin coconut oil; atherogenic index
ID DENSITY-LIPOPROTEIN-CHOLESTEROL; CARDIOVASCULAR RISK; POTENTIAL
   BENEFITS; ANTIOXIDANT STATUS; OXIDATIVE STRESS; LDL-CHOLESTEROL; HDL
   CHOLESTEROL; ATORVASTATIN; THERAPY; DISEASE
AB Objective: Statin monotherapy for dyslipidemia is limited by adverse effects and limited effectiveness in certain subgroups like metabolic syndrome. Add-on therapy with an agent with a known safety profile may improve clinical outcomes, and virgin coconut oil (VCO) may be the candidate agent for improving the cardiometabolic profile. The present study was conducted to evaluate the effect of add-on VCO with atorvastatin in dyslipidemia in adults.Methods: A randomized, double-blind clinical trial was conducted on 150 patients with dyslipidemia who were randomized into control and test groups. The control group received atorvastatin monotherapy, whereas the test group received add-on VCO with atorvastatin for 8 weeks. At baseline, demographic, clinical, and biochemical parameters were assessed and repeated after 8 weeks of therapy. The main outcome measures were lipid profile, cardiovascular risk indices, 10-year cardiovascular risk, body fat compositions, and thiobarbituric acid reactive substances (TBARS).Results: The increase in HDL in the test group was significantly greater than in the control group (MD: 2.76; 95%CI: 2.43-3.08; p < 0.001). The changes in the atherogenic index (p = 0.003), coronary risk index (p < 0.001), cardiovascular risk index (p = 0.001), and TBARS (p < 0.001) were significantly greater in the test group. The decrease in LDL, total cholesterol and lipoprotein(a), were significantly higher in the control group. There were no significant differences between the groups with respect to the changes in triglyceride, VLDL, and 10-year cardiovascular risk.Conclusions: Add-on VCO (1000 mg/day) with atorvastatin (10 mg/day) can achieve a better clinical outcome in patients with dyslipidemia by increasing HDL and improving oxidative stress cardiovascular risk indices.
C1 [Maiti, Rituparna; Maji, Shampa; Padhan, Milan; Mishra, Archana] All India Inst Med Sci AIIMS, Dept Pharmacol, Bhubaneswar, India.
   [Mohanty, Rashmi Ranjan; Dey, Anupam] All India Inst Med Sci AIIMS, Dept Gen Med, Bhubaneswar, Orissa, India.
   [Maiti, Rituparna] All India Inst Med Sci AIIMS, Dept Pharmacol, Bhubaneswar, Orissa, India.
C3 All India Institute of Medical Sciences (AIIMS) Bhubaneswar; All India
   Institute of Medical Sciences (AIIMS) Bhubaneswar; All India Institute
   of Medical Sciences (AIIMS) Bhubaneswar
RP Maiti, R (corresponding author), All India Inst Med Sci AIIMS, Dept Pharmacol, Bhubaneswar, Orissa, India.
EM pharm_rituparna@aiimsbhubaneswar.edu.in
RI MAITI, RITUPARNA/MFI-2945-2025
OI Padhan, Milan/0000-0003-3092-1081; , Archana/0000-0001-8837-299X; Maji,
   Dr. Shampa/0000-0002-5249-1505; MAITI, RITUPARNA/0000-0003-4063-9178
FU Coconut Development Board (CDB); Ministry of Agriculture and Farmers
   Welfare, Government of India
FX The first author received financial assistance from Coconut Development
   Board (CDB), Ministry of Agriculture and Farmers Welfare, Government of
   India
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NR 37
TC 1
Z9 1
U1 0
U2 2
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 2769-7061
EI 2769-707X
J9 J AM NUTR ASSOC
JI J. Am. Nutr. Assoc.
PD APR 2
PY 2024
VL 43
IS 3
BP 244
EP 251
DI 10.1080/27697061.2023.2256816
EA SEP 2023
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA LV2Z3
UT WOS:001068870600001
PM 37708389
DA 2025-06-11
ER

PT J
AU Barber, TM
   Kyrou, I
   Kaltsas, G
   Grossman, AB
   Randeva, HS
   Weickert, MO
AF Barber, Thomas M.
   Kyrou, Ioannis
   Kaltsas, Gregory
   Grossman, Ashley B.
   Randeva, Harpal S.
   Weickert, Martin O.
TI Mechanisms of Central Hypogonadism
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE hypogonadism; prolactin; leptin; Kallmann syndrome; stress
ID IDIOPATHIC HYPOGONADOTROPIC HYPOGONADISM; FUNCTIONAL HYPOTHALAMIC
   AMENORRHEA; ANABOLIC-ANDROGENIC STEROIDS; KALLMANN-SYNDROME;
   DISCONNECTION HYPERPROLACTINEMIA; PHENOTYPIC SPECTRUM;
   HYPER-PROLACTINEMIA; METABOLIC SYNDROME; ADIPOSE-TISSUE; MALE OBESITY
AB Reproductive function depends upon an operational hypothalamo-pituitary-gonadal (HPG) axis. Due to its role in determining survival versus reproductive strategies, the HPG axis is vulnerable to a diverse plethora of signals that ultimately manifest with Central Hypogonadism (CH) in all its many guises. Acquired CH can result from any pituitary or hypothalamic lesion, including its treatment (such as surgical resection and/or radiotherapy). The HPG axis is particularly sensitive to the suppressive effects of hyperprolactinaemia that can occur for many reasons, including prolactinomas, and as a side effect of certain drug therapies. Physiologically, prolactin (combined with the suppressive effects of autonomic neural signals from suckling) plays a key role in suppressing the gonadal axis and establishing temporary CH during lactation. Leptin is a further key endocrine regulator of the HPG axis. During starvation, hypoleptinaemia (from diminished fat stores) results in activation of hypothalamic agouti-related peptide neurons that have a dual purpose to enhance appetite (important for survival) and concomitantly suppresses GnRH neurons via effects on neural kisspeptin release. Obesity is associated with hyperleptinaemia and leptin resistance that may also suppress the HPG axis. The suppressibility of the HPG axis also leaves it vulnerable to the effects of external signals that include morphine, anabolic-androgenic steroids, physical trauma and stress, all of which are relatively common causes of CH. Finally, the HPG axis is susceptible to congenital malformations, with reports of mutations within >50 genes that manifest with congenital CH, including Kallmann Syndrome associated with hyposmia or anosmia (reduction or loss of the sense of smell due to the closely associated migration of GnRH with olfactory neurons during embryogenesis). Analogous to the HPG axis itself, patients with CH are often vulnerable, and their clinical management requires both sensitivity and empathy.
C1 [Barber, Thomas M.; Kyrou, Ioannis; Randeva, Harpal S.; Weickert, Martin O.] Univ Hosp Coventry & Warwickshire, Warwickshire Inst Study Diabet Endocrinol & Metab, Clifford Bridge Rd, Coventry CV2 2DX, W Midlands, England.
   [Barber, Thomas M.; Kyrou, Ioannis; Randeva, Harpal S.; Weickert, Martin O.] Univ Warwick, Warwick Med Sch, Div Biomed Sci, Coventry CV2 2DX, W Midlands, England.
   [Kyrou, Ioannis; Randeva, Harpal S.] Aston Univ, Coll Hlth & Life Sci, Aston Med Sch, Aston Med Res Inst, Birmingham B4 7ET, W Midlands, England.
   [Kyrou, Ioannis; Weickert, Martin O.] Coventry Univ, Fac Hlth & Life Sci, Ctr Sport Exercise & Life Sci, Coventry CV2 2DX, W Midlands, England.
   [Kaltsas, Gregory] Natl & Kapodistrian Univ Athens, Athens 10679, Greece.
   [Grossman, Ashley B.] Univ Oxford, Green Templeton Coll, Oxford OX2 6HG, England.
   [Grossman, Ashley B.] Univ London, Barts & London Sch Med, London E1 2AD, England.
C3 University of Warwick; University of Warwick; Aston University; Coventry
   University; National & Kapodistrian University of Athens; University of
   Oxford; University of London; Queen Mary University London
RP Barber, TM; Weickert, MO (corresponding author), Univ Hosp Coventry & Warwickshire, Warwickshire Inst Study Diabet Endocrinol & Metab, Clifford Bridge Rd, Coventry CV2 2DX, W Midlands, England.; Barber, TM; Weickert, MO (corresponding author), Univ Warwick, Warwick Med Sch, Div Biomed Sci, Coventry CV2 2DX, W Midlands, England.; Weickert, MO (corresponding author), Coventry Univ, Fac Hlth & Life Sci, Ctr Sport Exercise & Life Sci, Coventry CV2 2DX, W Midlands, England.
EM t.barber@warwick.ac.uk; kyrouj@gmail.com; gkaltsas@endo.gr;
   ashley.grossman@ocdem.ox.ac.uk; harpal.randeva@uhcw.nhs.uk;
   Martin.Weickert@uhcw.nhs.uk
RI Weickert, Martin/C-2207-2009
OI Barber, Thomas/0000-0003-0689-9195; Weickert, Martin
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NR 122
TC 28
Z9 29
U1 3
U2 14
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD AUG
PY 2021
VL 22
IS 15
AR 8217
DI 10.3390/ijms22158217
PG 18
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA TV7AG
UT WOS:000681871100001
PM 34360982
OA Green Published, Green Accepted, gold
DA 2025-06-11
ER

PT J
AU Tzounakas, VL
   Anastasiadi, AT
   Drossos, PV
   Karadimas, DG
   Valsami, SI
   Stamoulis, KE
   Papassideri, IS
   Politou, M
   Antonelou, MH
   Kriebardis, AG
AF Tzounakas, Vassilis L.
   Anastasiadi, Alkmini T.
   Drossos, Panagiotis, V
   Karadimas, Dimitrios G.
   Valsami, Serena, I
   Stamoulis, Konstantinos E.
   Papassideri, Issidora S.
   Politou, Marianna
   Antonelou, Marianna H.
   Kriebardis, Anastasios G.
TI Sex-related aspects of the red blood cell storage lesion
SO BLOOD TRANSFUSION
LA English
DT Article
DE red cell storage lesion; donor variation; female donors; menopause
ID URIC-ACID; METABOLIC SYNDROME; DONOR; ERYTHROCYTE; PLASMA; HEMOGLOBIN;
   HEMOLYSIS; STRESS; GENDER; SUSCEPTIBILITY
AB Background - Several factors contribute to the manifestation of red blood cell (RBC) storage lesions, with one of the most interesting being the "donor variation effect". Since many haematological characteristics of blood donors are sex-dependent, sex hormones and their age-dependent variation may affect the storage profile of RBCs.
   Materials and methods - Fresh blood from 200 healthy male and female donors underwent haematological, biochemical and physiological analysis. Three selected groups of donors (men, n=8; pre-menopausal women, n=8; and post-menopausal women, n=4) exhibiting as similar as possible baseline values were recruited for blood donation in leukoreduced CPD/SAGM units. RBC indices, haemolysis and propensity for haemolysis, reactive oxygen species (ROS) and plasma antioxidant capacity were measured bi-weekly.
   Results - Female blood was characterised by lower plasma antioxidant capacity and free haemoglobin (Hb) levels in vivo, in spite of the higher RBC osmotic fragility, compared to male blood. Comparatively low Hb concentration was also measured in stored RBCs from female donors, as in vivo. Mean corpuscular Hb (MCH), mean corpuscular Hb concentration (MCHC), and plasma antioxidant capacity were also lower in female donors throughout storage, even though baseline levels were equal to those of the male group. There was no difference in propensity of stored RBCs for haemolysis between male and female units but intracellular ROS levels were significantly lower in female RBCs. Increased end-of-storage extracellular potassium and recruitment of protein stress markers (clusterin, Hb) to the RBC membrane were observed in the units of post- vs pre-menopausal female donors at mid-storage onwards.
   Discussion - Donor's sex has an impact on Hb concentration and redox parameters of stored RBCs. In addition, menopause seems to promote RBC membrane remodelling, at least during prolonged storage. Our pilot study provides new insights on the different effects on RBC storage lesion according to sex.
C1 [Tzounakas, Vassilis L.; Anastasiadi, Alkmini T.; Karadimas, Dimitrios G.; Papassideri, Issidora S.; Antonelou, Marianna H.] Natl & Kapodistrian Univ Athens NKUA, Sch Sci, Dept Biol, Athens, Greece.
   [Drossos, Panagiotis, V; Kriebardis, Anastasios G.] Univ West Attica UniWA, Sch Hlth & Welf Sci, Dept Biomed Sci, Lab Reliabil & Qual Control Lab Haematol HemQcR, Egaleo City, Greece.
   [Valsami, Serena, I; Politou, Marianna] Natl & Kapodistrian Univ Athens, Aretaie Hosp, Sch Med, Blood Bank, Athens, Greece.
   [Valsami, Serena, I; Politou, Marianna] Natl & Kapodistrian Univ Athens, Aretaie Hosp, Sch Med, Haematol Lab, Athens, Greece.
   [Stamoulis, Konstantinos E.] Hellen Natl Blood Transfus Ctr, Acharnes, Greece.
C3 National & Kapodistrian University of Athens; National & Kapodistrian
   University of Athens; Athens Medical School; National & Kapodistrian
   University of Athens; Athens Medical School
RP Antonelou, MH (corresponding author), Natl & Kapodistrian Univ Athens NKUA, Sch Sci, Dept Biol, Athens, Greece.
EM manton@biol.uoa.gr
RI Kriebardis, Anastasios/G-5546-2010; Stamoulis, Konstantinos/V-2501-2019;
   Tzounakas, Vassilis/AAT-3892-2021; VALSAMI, SERENA/AAB-4895-2020;
   Antonelou, Marianna/C-1267-2011; Anastasiadi, Alkmini/AAT-2725-2021
OI Tzounakas, Vassilis/0009-0002-3697-001X; Anastasiadi,
   Alkmini/0009-0007-3165-7493
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NR 52
TC 33
Z9 33
U1 1
U2 7
PU SIMTIPRO SRL
PI MILAN
PA VIA DESIDERIO 21, MILAN, 20131, ITALY
SN 1723-2007
J9 BLOOD TRANSFUS-ITALY
JI Blood Transf.
PD MAY-JUN
PY 2021
VL 19
IS 3
BP 224
EP 236
DI 10.2450/2020.0141-20
PG 13
WC Hematology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Hematology
GA RU5SC
UT WOS:000645206800006
PM 33085592
DA 2025-06-11
ER

PT J
AU Cheng, K
   Ji, SL
   Jia, PL
   Zhang, H
   Wang, T
   Song, ZH
   Zhang, LL
   Wang, T
AF Cheng, Kang
   Ji, Shuli
   Jia, Peilu
   Zhang, Hao
   Wang, Ting
   Song, Zhihua
   Zhang, Lili
   Wang, Tian
TI Resveratrol Improves Hepatic Redox Status and Lipid Balance of Neonates
   with Intrauterine Growth Retardation in a Piglet Model
SO BIOMED RESEARCH INTERNATIONAL
LA English
DT Article
ID FATTY LIVER-DISEASE; ANTIOXIDANT CAPACITY; OXIDATIVE STRESS;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; RISK-FACTORS; DAMAGE;
   SUPPLEMENTATION; RESTRICTION; PERFORMANCE
AB Abnormal lipid metabolism, oxidative stress (OS), and inflammation play a pivotal role in the increased susceptibility to neonatal fatty liver diseases associated with intrauterine growth retardation (IUGR). This study was firstly conducted to investigate whether resveratrol could alleviate IUGR-induced hepatic lipid accumulation, alteration of redox and immune status in a sucking piglet model and explore the possible mechanisms at transcriptional levels. A total of 36 pairs of 7 d old male normal birth weight (NBW) and IUGR piglets were orally fed with either 80 mg resveratrol/kg body weight/d or 0.5% carboxymethylcellulose sodium for a period of 14 days, respectively. Compared with the NBW piglets, the IUGR piglets displayed compromised growth performance and liver weight, reduced plasma free fatty acid (FFA) level, increased hepatic OS, abnormal hepatic lipid accumulation and weakened hepatic immune function, and hepatic aberrant transcriptional expression of some genes such as heme oxygenase 1, superoxide dismutase 1, sterol regulatory element-binding protein 1c, stearoyl-CoA desaturase 1, liver fatty acid-binding proteins 1, toll-like receptor 4, and tumor necrosis factor alpha (TNF-alpha). Oral administration of resveratrol to piglets decreased the levels of FFA and total triglycerides (TG) in the plasma and hepatic TNF-alpha concentration, and increased glutathione reductase activity and reduced glutathione level in the liver. Resveratrol restored the increased alanine aminotransferase activity in the plasma of IUGR piglets. Treatment with resveratrol ameliorated the increased hepatic malondialdehyde, protein carbonyl, TG, and FFA concentrations induced by IUGR. Resveratrol treatment alleviated the reduced lipoprotein lipase activity and its mRNA expression as well as TNF-alpha gene expression in the liver of IUGR piglets. Hepatic glutathione peroxidase 1 and monocyte chemotactic protein 1 genes expression of piglets was upregulated by oral resveratrol administration. In conclusion, resveratrol administration plays a beneficial role in hepatic redox status and lipid balance of the IUGR piglets.
C1 [Cheng, Kang; Ji, Shuli; Jia, Peilu; Zhang, Hao; Wang, Ting; Song, Zhihua; Zhang, Lili; Wang, Tian] Nanjing Agr Univ, Coll Anim Sci & Technol, Nanjing 210095, Peoples R China.
C3 Nanjing Agricultural University
RP Zhang, LL; Wang, T (corresponding author), Nanjing Agr Univ, Coll Anim Sci & Technol, Nanjing 210095, Peoples R China.
EM zhanglili@njau.edu.cn; tianwangnjau@163.com
FU Fundamental Research Funds for the Central Universities [KJQN201935];
   National Natural Science Foundation of China [31802101, 31772634,
   31802094]; Natural Science Foundation of Jiangsu Province [BK20180531]
FX The present study was supported by the Fundamental Research Funds for
   the Central Universities (Grant No. KJQN201935), the National Natural
   Science Foundation of China (Grant Nos. 31802101, 31772634, and
   31802094), and the Natural Science Foundation of Jiangsu Province
   (Grants No BK20180531).
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NR 46
TC 12
Z9 14
U1 0
U2 9
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2314-6133
EI 2314-6141
J9 BIOMED RES INT
JI Biomed Res. Int.
PD JUL 18
PY 2020
VL 2020
AR 7402645
DI 10.1155/2020/7402645
PG 12
WC Biotechnology & Applied Microbiology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Research & Experimental Medicine
GA MV2XQ
UT WOS:000556226500007
PM 33457413
OA Green Published
DA 2025-06-11
ER

PT J
AU Chaves, AJM
   Cunha, NL
   de Souza, AG
   Soares, MVR
   Jucá, PM
   de Queiroz, T
   Oliveira, JVS
   Valvassori, SS
   Barichello, T
   Quevedo, J
   de Lucena, D
   Macedo, DS
AF Chaves Filho, Adriano Jose Maia
   Cunha, Natassia Lopes
   de Souza, Alana Gomes
   Soares, Michele Verde-Ramo
   Juca, Paloma Marinho
   de Queiroz, Tatiana
   Souza Oliveira, Joao Victor
   Valvassori, Samira S.
   Barichello, Tatiana
   Quevedo, Joao
   de Lucena, David
   Macedo, Danielle S.
TI The GLP-1 receptor agonist liraglutide reverses mania-like alterations
   and memory deficits induced by D-amphetamine and augments lithium
   effects in mice: Relevance for bipolar disorder
SO PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
LA English
DT Article
DE Bipolar disorder; Mania; GLP-1; Liraglutide; D-amphetamine; Cognitive
   impairment; Oxidative stress; Brain-derived neurotrophic factor (BDNF)
ID OXIDATIVE STRESS; NEUROTROPHIC FACTOR; ANIMAL-MODEL; COGNITIVE
   IMPAIRMENT; INSULIN-RESISTANCE; PEPTIDE-1 RECEPTOR; LIPID-PEROXIDATION;
   EXECUTIVE FUNCTION; METABOLIC SYNDROME; PREFRONTAL CORTEX
AB Metabolic and psychiatric disorders present a bidirectional relationship. GLP-1 system, known for its insulinotropic effects, has also been associated with numerous regulatory effects in cognitive and emotional processing. GLP-1 receptors (GLP-1R) agonists present neuroprotective and antidepressant/anxiolytic properties. However, the effects of GLP-1R agonism in bipolar disorder (BD) mania and the related cognitive disturbances remains unknown. Here, we investigated the effects of the GLP-1R agonist liraglutide (LIRA) at monotherapy or combined with lithium (Li) against D-amphetamine (AMPH)-induced mania-like symptoms, brain oxidative and BDNF alterations in mice. Swiss mice received AMPH 2 mg/kg or saline for 14 days. Between days 8-14, they received LIRA 120 or 240 mu g/kg, Li 47.5 mg/kg or the combination Li + LIRA, on both doses. After behavioral evaluation the brain areas prefrontal cortex (PFC), hippocampus and amygdala were collected. AMPH induced hyperlocomotion, risk-taking behavior and multiple cognitive deficits which resemble mania. LIRA reversed AMPH-induced hyperlocomotion, working and recognition memory impairments, while Li + LIRA240 rescued all behavioral changes induced by AMPH. LIRA reversed AMPH-induced hippocampal oxidative and neurotrophic changes. Li + LIRA240 augmented Li antioxidant effects and greatly reversed AMPH-induced BDNF changes in PFC and hippocampus. LIRA rescued the weight gain induced by Li in the course of mania model. Therefore, LIRA can reverse some mania-like behavioral alterations and combined with Li augmented the mood stabilizing and neuroprotective properties of Li. This study points to LIRA as a promising adjunctive tool for BD treatment and provides the first rationale for the design of clinical trials investigating its possible antimanic effect.
C1 [Chaves Filho, Adriano Jose Maia; Cunha, Natassia Lopes; de Souza, Alana Gomes; Soares, Michele Verde-Ramo; Juca, Paloma Marinho; de Queiroz, Tatiana; Souza Oliveira, Joao Victor; de Lucena, David; Macedo, Danielle S.] Univ Fed Ceara, Fac Med, Neuropharmacol Lab, Dept Physiol & Pharmacol,Drug Res & Dev Ctr, Fortaleza, Ceara, Brazil.
   [Valvassori, Samira S.; Barichello, Tatiana; Quevedo, Joao] Univ Southern Santa Catarina UNESC, Hlth Sci Unit, Lab Neurosci, Grad Program Hlth Sci, Criciuma, SC, Brazil.
   [Barichello, Tatiana; Quevedo, Joao] Univ Texas Hlth Sci Ctr Houston UTHlth, McGovern Med Sch, Dept Psychiat & Behav Sci, Translat Psychiat Program, Houston, TX USA.
   [Barichello, Tatiana; Quevedo, Joao] Univ Texas Hlth Sci Ctr Houston UTHlth, Ctr Excellence Mood Disorders, McGovern Med Sch, Dept Psychiat & Behav Sci, Houston, TX USA.
   [Barichello, Tatiana; Quevedo, Joao] Univ Texas Grad Sch Biomed Sci Houston, Neurosci Grad Program, Houston, TX USA.
   [Macedo, Danielle S.] CNPq, Natl Inst Translat Med INCT TM, Ribeirao Preto, SP, Brazil.
C3 Universidade Federal do Ceara; Universidade do Sul de Santa Catarina;
   University of Texas System; University of Texas Health Science Center
   Houston; Baylor College of Medicine; Baylor College Medical Hospital;
   University of Texas System; University of Texas Health Science Center
   Houston; Baylor College of Medicine; Baylor College Medical Hospital;
   University of Texas System; University of Texas Health Science Center
   Houston; University of Texas Graduate School of Biomedical Sciences
RP Macedo, DS (corresponding author), Univ Fed Ceara, Dept Physiol & Pharmacol, Rua Cel Nunes de Melo 1000, BR-60430275 Fortaleza, Ceara, Brazil.
EM danielle.macedo@ufc.br
RI Barichello, Tatiana/E-2725-2013; Jucá, Paloma/ABC-4365-2021; Valvassori,
   Samira/KHD-9552-2024; Chaves-Filho, Adriano/AAZ-1390-2020; DE Lucena,
   David/LBI-5222-2024; de Quevedo, Joao Luciano/E-5491-2013; Macedo,
   Danielle/E-3424-2014
OI DE Lucena, David/0000-0002-1547-3711; Juca, Paloma
   Marinho/0000-0001-8432-8430; de Quevedo, Joao
   Luciano/0000-0003-3114-6611; Souza oliveira, Joao
   Victor/0009-0002-7274-030X; S. Valvassori, Samira/0000-0003-4824-7742;
   Macedo, Danielle/0000-0001-8980-9970
FU Brazilian Institution CAPES; Brazilian Institution FUNCAP; Brazilian
   Institution CNPq
FX The authors thank the Brazilian Institutions CAPES, FUNCAP and CNPq for
   the financial support of this study.
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NR 126
TC 26
Z9 27
U1 2
U2 15
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0278-5846
EI 1878-4216
J9 PROG NEURO-PSYCHOPH
JI Prog. Neuro-Psychopharmacol. Biol. Psychiatry
PD APR 20
PY 2020
VL 99
AR 109872
DI 10.1016/j.pnpbp.2020.109872
PG 15
WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA KT1GA
UT WOS:000518756400038
PM 31954756
DA 2025-06-11
ER

PT J
AU Yencilek, E
   Sari, H
   Yencilek, F
   Yesil, E
   Aydin, H
AF Yencilek, Esin
   Sari, Hakan
   Yencilek, Faruk
   Yesil, Ezgi
   Aydin, Hasan
TI Systemic endothelial function measured by flow-mediated dilation is
   impaired in patients with urolithiasis
SO UROLITHIASIS
LA English
DT Article
DE Urolithiasis; Endothelial dysfunction; Flow-mediated dilation;
   Cardiovascular risk
ID CORONARY-HEART-DISEASE; KIDNEY-STONES; OXIDATIVE STRESS;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; OXIDANT STRESS; DYSFUNCTION;
   RISK; NEPHROLITHIASIS; OBESITY
AB Some in vitro and animal studies have shown endothelial dysfunction in hyperoxaluria models indicating its role in pathogenesis of urolithiasis and relation to CVD. The aim of this study was to investigate endothelial function in patients with urolithiasis in relation to urinary stone risk factors and metabolic parameters. A total of 120 subjects without any known CVD (60 with urolithiasis and 60 healthy subjects) were included into study. Fasting blood and 24-h urine samples were collected to study metabolic parameters (glucose and lipids) and urine stone risk factors (oxalate, citrate, uric acid, and calcium, pH). Endothelial function was assessed as flow-mediated dilation (FMD) at the brachial artery. Age, sex, and body mass index were similar in patients and controls. Of urine stone risk factors, oxalate and citrate were higher in patients than controls. Fasting blood glucose, total LDL cholesterol, and triglyceride were higher, and HDL cholesterol was lower in patients than controls. Although within normal limits systolic blood pressure was higher in patient group, patients with urolithiasis had a lower %FMD than controls. Percent FMD was negatively correlated with urinary oxalate/creatinine ratio (p = 0.019, r = -0.315), calcium/creatinine ratio (p = 0.0001, r = -0.505) age (p < 0.001, r = -0.694), BMI (p < 0.001, r = -0.838), total cholesterol (p < 0.001, r = -0.559), and triglyceride (p < 0.001, r = -0.529). Urine oxalate/creatinine ratio was positively correlated with age (p = 0.01, r = 0.327) and calcium/creatinine ratio with BMI (p = 0.001, r = 0.410). This is the first study demonstrating endothelial dysfunction in human subjects with urolithiasis. This indicates a possible predictive role of urolithiasis in future development of cardiovascular diseases.
C1 [Yencilek, Esin] Haydarpasa Numune Educ & Training Hosp, Dept Radiol, Istanbul, Turkey.
   [Sari, Hakan] Bagcilar Educ & Training Hosp, Dept Internal Med, Istanbul, Turkey.
   [Yencilek, Faruk] Yeditepe Univ, Med Fac, Dept Urol, Istanbul, Turkey.
   [Yesil, Ezgi] Umraniye Educ & Training Hosp, Dept Nephrol, Istanbul, Turkey.
   [Aydin, Hasan] Yeditepe Univ, Med Fac, Dept Endocrinol & Metab, Istanbul, Turkey.
   [Aydin, Hasan] Yeditepe Univ Hastanesi, Hastane Yolu Sokak 102-104, TR-34752 Istanbul, Turkey.
C3 Istanbul Haydarpasa Numune Training & Research Hospital; Istanbul
   Bagcilar Training & Research Hospital; Yeditepe University; Yeditepe
   University; Yeditepe University
RP Aydin, H (corresponding author), Yeditepe Univ, Med Fac, Dept Endocrinol & Metab, Istanbul, Turkey.; Aydin, H (corresponding author), Yeditepe Univ Hastanesi, Hastane Yolu Sokak 102-104, TR-34752 Istanbul, Turkey.
EM haydin@yeditepe.edu.tr
OI ersoy yesil, ezgi/0000-0001-5550-6947
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NR 38
TC 11
Z9 11
U1 1
U2 2
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 2194-7228
EI 2194-7236
J9 UROLITHIASIS
JI Urolithiasis
PD DEC
PY 2017
VL 45
IS 6
BP 545
EP 552
DI 10.1007/s00240-016-0941-2
PG 8
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA FK8OQ
UT WOS:000413768500004
PM 27882414
DA 2025-06-11
ER

PT J
AU Butani, L
   Dharmar, M
   Devaraj, S
   Jialal, I
AF Butani, Lavjay
   Dharmar, Madan
   Devaraj, Sridevi
   Jialal, Ishwarlal
TI Preliminary Report of Inflammatory Markers, Oxidative Stress, and
   Insulin Resistance in Adolescents of Different Ethnicities
SO METABOLIC SYNDROME AND RELATED DISORDERS
LA English
DT Article
ID ALPHA-TOCOPHEROL SUPPLEMENTATION; TYPE-2 DIABETIC-PATIENTS; SOLUBLE
   ADHESION MOLECULES; C-REACTIVE PROTEIN; METABOLIC SYNDROME;
   CARDIOVASCULAR-DISEASE; CHILDREN; OBESITY; PREVALENCE; OVERWEIGHT
AB Background: Higher fasting glucose and hemoglobin A1C levels are seen more often in African American (AA) and Hispanic (H) youth, even after adjusting for body mass index (BMI), pointing to other factors that might be promoting abnormal glucose tolerance, such as inflammatory mediators. Our study compared markers of inflammation and oxidative stress in adolescents of different ethnicities.
   Methods: This was a cross-sectional cohort study of healthy Caucasian (C), H, and AA adolescents. Fasting urine for F2-isoprostanes and plasma for adiponectin, soluble vascular cell adhesion molecule (s-VCAM 1), interleukins (ILs), and tumor necrosis factor-alpha were collected and analyzed. Insulin resistance was measured by homeostasis model assessment of insulin resistance (HOMA-IR). Multivariable regression analyses were used to assess the effect of the biomarkers on HOMA-IR.
   Results: Seventy adolescents were enrolled (26 C, 20 A, and 24 H); 32 were male (46%) and 27 (39%) were obese. Exploratory analysis showed that for every 1 U increase in BMI z-score, IL-8 rose by 0.53 (0.05, 1.00), P = 0.03. On regression analyses, for every unit increase in BMI z-score, HOMA-IR increased by 0.67 U (P = 0.001); for every unit increase in IL-8, HOMA-IR decreased by 0.21 U (P = 0.04). None of the other biomarkers was significantly associated with HOMA-IR.
   Conclusions: Higher insulin resistance was associated with increasing BMI z-scores and lower IL-8. This pilot study demonstrates the need to further evaluate inflammatory markers as an independent risk factor for the development of diabetes and to explore if there is a cause and effect relationship between IL-8 and insulin resistance. This could prove valuable for early identification of insulin resistance and as targets for intervention.
C1 [Butani, Lavjay; Dharmar, Madan] Univ Calif Davis, Childrens Hosp, Dept Pediat, Sacramento, CA 95817 USA.
   [Devaraj, Sridevi] Baylor Coll Med, Dept Pathol & Immunol, Houston, TX 77030 USA.
   [Jialal, Ishwarlal] Univ Calif Davis, Dept Pathol & Lab Med, Sacramento, CA 95817 USA.
   [Jialal, Ishwarlal] Univ Calif Davis, Internal Med, Sacramento, CA 95817 USA.
C3 University of California System; University of California Davis;
   Children's Hospital Los Angeles; Baylor College of Medicine; University
   of California System; University of California Davis; University of
   California System; University of California Davis
RP Butani, L (corresponding author), Univ Calif Davis, Childrens Hosp, 2516 Stockton Blvd,Room 348, Sacramento, CA 95817 USA.
EM lbutani@ucdavis.edu
RI Dharmar, Madan/J-5854-2013; Jialal, Ishwarlal/AAG-6218-2019
FU Children's Miracle Network
FX Children's Miracle Network.
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NR 31
TC 4
Z9 4
U1 0
U2 7
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-4196
EI 1557-8518
J9 METAB SYNDR RELAT D
JI Metab. Syndr. Relat. Disord.
PD APR 1
PY 2016
VL 14
IS 3
BP 182
EP 186
DI 10.1089/met.2015.0161
PG 5
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA DH0EP
UT WOS:000372455600008
PM 26824677
DA 2025-06-11
ER

PT J
AU Lee, HY
   Kim, J
   Quan, W
   Lee, JC
   Kim, MS
   Kim, SH
   Bae, JW
   Hur, KY
   Lee, MS
AF Lee, Hae-Youn
   Kim, Jinyoung
   Quan, Wenying
   Lee, June-Chul
   Kim, Min-Soo
   Kim, Seok-Hyung
   Bae, Jin-Woo
   Hur, Kyu Yeon
   Lee, Myung-Shik
TI Autophagy deficiency in myeloid cells increases susceptibility to
   obesity-induced diabetes and experimental colitis
SO AUTOPHAGY
LA English
DT Article
DE autophagy; colitis; diabetes; inflammasome; macrophages; obesity
ID ENDOPLASMIC-RETICULUM STRESS; ISLET AMYLOID POLYPEPTIDE;
   INSULIN-RESISTANCE; NLRP3 INFLAMMASOME; CROHNS-DISEASE; ADIPOSE-TISSUE;
   INTESTINAL HOMEOSTASIS; IL-1-BETA PRODUCTION; ADIPOCYTE DEATH; DENDRITIC
   CELLS
AB Autophagy, which is critical for the proper turnover of organelles such as endoplasmic reticulum and mitochondria, affects diverse aspects of metabolism, and its dysregulation has been incriminated in various metabolic disorders. However, the role of autophagy of myeloid cells in adipose tissue inflammation and type 2 diabetes has not been addressed. We produced mice with myeloid cell-specific deletion of Atg7 (autophagy-related 7), an essential autophagy gene (Atg7 conditional knockout [cKO] mice). While Atg7 cKO mice were metabolically indistinguishable from control mice, they developed diabetes when bred to ob/w mice (Atg7 cKO-ob/ob mice), accompanied by increases in the crown-like structure, inflammatory cytokine expression and inflammasome activation in adipose tissue. M phi s (macrophages) from Atg7 cKO mice showed significantly higher interleukin 1 release and inflammasome activation in response to a palmitic acid plus lipopolysaccharide combination. Moreover, a decrease in the NAD(+):NADH ratio and increase in intracellular ROS content after treatment with palmitic acid in combination with lipopolysaccharide were more pronounced in M phi s from Atg7 cKO mice, suggesting that mitochondrial dysfunction in autophagy-deficient M phi s leads to an increase in lipid-induced inflammasome and metabolic deterioration in Atg7 cKO-ob/ob mice. Atg7 cKO mice were more susceptible to experimental colitis, accompanied by increased colonic cytokine expression, T helper 1 skewing and systemic bacterial invasion. These results suggest that autophagy of M phi s is important for the control of inflammasome activation in response to metabolic or extrinsic stress, and autophagy deficiency in M phi s may contribute to the progression of metabolic syndrome associated with lipid injury and colitis.
C1 [Lee, Hae-Youn; Quan, Wenying; Lee, June-Chul; Hur, Kyu Yeon] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Med, Seoul, South Korea.
   [Kim, Jinyoung; Lee, Myung-Shik] Yonsei Univ, Coll Med, Severance Biomed Sci Inst, Seoul, South Korea.
   [Kim, Jinyoung; Lee, Myung-Shik] Yonsei Univ, Coll Med, Dept Internal Med, Seoul, South Korea.
   [Kim, Jinyoung] Sungkyunkwan Univ, Sch Med, SAIHST, Dept Hlth Sci & Technol, Seoul, South Korea.
   [Kim, Min-Soo; Bae, Jin-Woo] Kyung Hee Univ, Dept Life & Nanopharmaceut Sci, Seoul, South Korea.
   [Kim, Min-Soo; Bae, Jin-Woo] Kyung Hee Univ, Dept Biol, Seoul, South Korea.
   [Kim, Seok-Hyung] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Pathol, Seoul, South Korea.
C3 Sungkyunkwan University (SKKU); Samsung Medical Center; Yonsei
   University; Yonsei University Health System; Yonsei University; Yonsei
   University Health System; Sungkyunkwan University (SKKU); Kyung Hee
   University; Kyung Hee University; Sungkyunkwan University (SKKU);
   Samsung Medical Center
RP Lee, MS (corresponding author), Yonsei Univ, Coll Med, 50 Yonsei Ro Seodaemun Gu, Seoul 03722, South Korea.
EM mslee0923@yuhs.ac
RI Kim, Jin Man/HJO-8987-2023; Kim, Soo-Yeon/ADR-9663-2022; Lee,
   Myung/C-9606-2011; JINYOUNG, KIM/IAM-3353-2023; Bae, Jin-Woo/S-1955-2017
OI Kim, Min-Soo/0000-0002-7184-4396; Lee, Myung-Shik/0000-0003-3292-1720;
   Bae, Jin-Woo/0000-0001-6433-5270; Kim, Jinyoung/0000-0002-3810-8549
FU Global Research Laboratory Grant of the National Research Foundation of
   Korea [NRF-2010-00347]; Samsung Biomedical Research Institute grant
   [C-B1-120]; Ulsan National Institute of Science and Technology Research
   Fund [2014M3A9D8034459]; Bio & Medical Technology Development Program
   Fund of the National Research Foundation [NRF-2015M3A9B6073846]
FX This study was supported by the Global Research Laboratory Grant of the
   National Research Foundation of Korea (NRF-2010-00347) and the Samsung
   Biomedical Research Institute grant (C-B1-120). M-SL is the recipient of
   the Ulsan National Institute of Science and Technology Research Fund
   (2014M3A9D8034459) and the Bio & Medical Technology Development Program
   Fund of the National Research Foundation (NRF-2015M3A9B6073846).
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NR 77
TC 66
Z9 72
U1 1
U2 15
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1554-8627
EI 1554-8635
J9 AUTOPHAGY
JI Autophagy
PY 2016
VL 12
IS 8
BP 1390
EP 1403
DI 10.1080/15548627.2016.1184799
PG 14
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA DU6FI
UT WOS:000382309200012
PM 27337687
OA Bronze, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Oksuzyan, A
   Shkolnikova, M
   Vaupel, JW
   Christensen, K
   Shkolnikov, VM
AF Oksuzyan, Anna
   Shkolnikova, Maria
   Vaupel, James W.
   Christensen, Kaare
   Shkolnikov, Vladimir M.
TI Sex Differences in Biological Markers of Health in the Study of Stress,
   Aging and Health in Russia
SO PLOS ONE
LA English
DT Article
ID C-REACTIVE PROTEIN; CORONARY-HEART-DISEASE; SELF-RATED HEALTH; ALL-CAUSE
   MORTALITY; CARDIOVASCULAR-DISEASE; MYOCARDIAL-INFARCTION;
   BLOOD-PRESSURE; RISK-FACTORS; GENDER-DIFFERENCES; METABOLIC SYNDROME
AB Background
   The apparent contradiction that women live longer but have worse health than men, the so called male-female health-survival paradox, is very pronounced in Russia. The present study investigates whether men in Moscow are healthier than women at the level of biomarkers, and whether the associations between biomarkers and subjective health have sex-specific patterns.
   Materials
   Previously collected data in the study of Stress, Aging, and Health in Russia (SAHR, n = 1800) were used to examine sex differences in biomarkers and their associations with physical functioning and self-rated health.
   Results
   The present study found mixed directions and magnitudes for sex differences in biomarkers. Women were significantly disadvantaged with regard to obesity and waist circumference, whereas men had a tendency toward higher prevalence of electrocardiographic abnormalities. No sex differences were indicated in the prevalence of immunological biomarkers, and mixed patterns were found for lipid profiles. Many biomarkers were associated with physical functioning and general health. Obesity and waist circumference were related to lower physical functioning among females only, while major Q-wave abnormalities with high probabilities of myocardial infarction and atrial fibrillation or atrial flutter were associated with physical functioning and self-rated health among males only.
   Conclusion
   No clear patterns of sex differences in prevalence of high-risk levels of biomarkers suggest that the male-female health-survival paradox is weaker at the level of health biomarkers. We found some evidence that certain biomarkers reflecting pathophysiological changes in the organism that do not possess acute health risks, but over many years may lead to physical disability, are associated with physical functioning and self-rated health in women, whereas others reflecting more serious life-threatening pathophysiological changes are associated with physical functioning and self-rated health in men.
C1 [Oksuzyan, Anna; Vaupel, James W.; Shkolnikov, Vladimir M.] Max Planck Inst Demog Res, Rostock, Germany.
   [Oksuzyan, Anna; Christensen, Kaare] Univ Southern Denmark, Dept Epidemiol Biostat & Biodemog, Odense, Denmark.
   [Shkolnikova, Maria] Pirogov Moscow Med Univ, Sci & Clin Inst Pediatry, Moscow, Russia.
   [Vaupel, James W.; Christensen, Kaare] Max Planck Odense Ctr Biodemog Aging, Odense, Denmark.
   [Christensen, Kaare] Odense Univ Hosp, Dept Clin Genet, DK-5000 Odense, Denmark.
   [Christensen, Kaare] Odense Univ Hosp, Dept Clin Biochem & Pharmacol, DK-5000 Odense, Denmark.
   [Shkolnikov, Vladimir M.] New Econ Sch, Moscow, Russia.
C3 Max Planck Society; University of Southern Denmark; University of
   Southern Denmark; Odense University Hospital; University of Southern
   Denmark; Odense University Hospital; New Economic School
RP Oksuzyan, A (corresponding author), Max Planck Inst Demog Res, Rostock, Germany.
EM oksuzyan@demogr.mpg.de
RI ; Christensen, Kaare/C-2360-2009; Shkolnikova, Maria/E-2782-2014;
   Shkolnikov, Vladimir/D-2986-2017
OI Vaupel, James/0000-0003-0783-3905; Oksuzyan, Anna/0000-0003-4138-5886;
   Christensen, Kaare/0000-0002-5429-5292; Shkolnikova,
   Maria/0000-0001-7115-0186; Shkolnikov, Vladimir/0000-0003-2259-5423
FU US National Institute of Health [P01AG031719, R01AG026786]; VELUX
   foundation; Dynasty Foundation, Russia
FX The study was supported by the US National Institute of Health, grants
   P01AG031719 and R01AG026786
   (http://fds.duke.edu/db/Sanford/pparc/grants.html), and the VELUX
   foundation (http://veluxfonden.dk). Vladimir Shkolnikov was partly
   funded by the Dynasty Foundation, Russia. The funders had no role in
   study design, data collection and analysis, decision to publish, or
   preparation of the manuscript.
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NR 86
TC 13
Z9 15
U1 1
U2 11
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JUN 29
PY 2015
VL 10
IS 6
AR e0131691
DI 10.1371/journal.pone.0131691
PG 18
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA CN1BL
UT WOS:000358150400144
PM 26121035
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Dreja, T
   Jovanovic, Z
   Rasche, A
   Kluge, R
   Herwig, R
   Tung, YCL
   Joost, HG
   Yeo, GSH
   Al-Hasani, H
AF Dreja, T.
   Jovanovic, Z.
   Rasche, A.
   Kluge, R.
   Herwig, R.
   Tung, Y. C. L.
   Joost, H. G.
   Yeo, G. S. H.
   Al-Hasani, H.
TI Diet-induced gene expression of isolated pancreatic islets from a
   polygenic mouse model of the metabolic syndrome
SO DIABETOLOGIA
LA English
DT Article
DE Expression profiling; Genome-wide association study; Glucotoxicity;
   Laser capture microdissection; Lipotoxicity; New Zealand obese mouse;
   Obesity; Oxidative phosphorylation; Pancreas
ID GENOME-WIDE ASSOCIATION; OXIDATIVE-PHOSPHORYLATION; SUSCEPTIBILITY
   LOCUS; CARBOHYDRATE; METAANALYSIS; GLUCOSE; PROTEIN; OBESITY; MICE;
   HYPERGLYCEMIA
AB Numerous new genes have recently been identified in genome-wide association studies for type 2 diabetes. Most are highly expressed in beta cells and presumably play important roles in their function. However, these genes account for only a small proportion of total risk and there are likely to be additional candidate genes not detected by current methodology. We therefore investigated islets from the polygenic New Zealand mouse (NZL) model of diet-induced beta cell dysfunction to identify novel genes and pathways that may play a role in the pathogenesis of diabetes.
   NZL mice were fed a diabetogenic high-fat diet (HF) or a diabetes-protective carbohydrate-free HF diet (CHF). Pancreatic islets were isolated by laser capture microdissection (LCM) and subjected to genome-wide transcriptome analyses.
   In the prediabetic state, 2,109 islet transcripts were differentially regulated (> 1.5-fold) between HF and CHF diets. Of the genes identified, 39 (e.g. Cacna1d, Chd2, Clip2, Igf2bp2, Dach1, Tspan8) correlated with data from the Diabetes Genetics Initiative and Wellcome Trust Case Control Consortium genome-wide scans for type 2 diabetes, thus validating our approach. HF diet induced early changes in gene expression associated with increased cell-cycle progression, proliferation and differentiation of islet cells, and oxidative stress (e.g. Cdkn1b, Tmem27, Pax6, Cat, Prdx4 and Txnip). In addition, pathway analysis identified oxidative phosphorylation as the predominant gene-set that was significantly upregulated in response to the diabetogenic HF diet.
   We demonstrated that LCM of pancreatic islet cells in combination with transcriptional profiling can be successfully used to identify novel candidate genes for diabetes. Our data strongly implicate glucose-induced oxidative stress in disease progression.
C1 [Dreja, T.; Kluge, R.; Joost, H. G.; Al-Hasani, H.] German Inst Human Nutr Potsdam Rehbrucke, Dept Pharmacol, D-14558 Nuthetal, Germany.
   [Jovanovic, Z.; Tung, Y. C. L.; Yeo, G. S. H.] Univ Cambridge, Addenbrookes Hosp, Metab Res Labs, Inst Metab Sci, Cambridge CB2 0QQ, England.
   [Rasche, A.; Herwig, R.] Max Planck Inst Mol Genet, Dept Vertebrate Genom, Berlin, Germany.
C3 Leibniz Association; Deutsches Institut fur Ernahrungsforschung
   Potsdam-Rehbrucke (DIfE); Cambridge University Hospitals NHS Foundation
   Trust; Addenbrooke's Hospital; University of Cambridge; Max Planck
   Society
RP Al-Hasani, H (corresponding author), German Inst Human Nutr Potsdam Rehbrucke, Dept Pharmacol, Arthur Scheunert Allee 114-116, D-14558 Nuthetal, Germany.
EM gshy2@cam.ac.uk; al-hasani@dife.de
RI O'Rahilly, Stephen/ABF-6509-2020; Joost, Hans-Georg/J-4462-2013
OI Herwig, Ralf/0000-0002-9335-1760; Yeo, Giles See
   How/0000-0001-8823-3615; Al-Hasani, Hadi/0000-0003-2543-0130; Joost,
   Hans-Georg/0000-0002-5860-606X
FU European Union [LSHM-CT-2004-512013, LSHG-CT-2006-37457]; Gates
   Cambridge Trust; UK Medical Research Council's Centre for Obesity and
   Related Metabolic Disorders (MRC-CORD); MRC [G0600717] Funding Source:
   UKRI
FX This work was supported in part by the European Union (EUGENE2,
   LSHM-CT-2004-512013; SysProt, LSHG-CT-2006-37457), the Gates Cambridge
   Trust and the UK Medical Research Council's Centre for Obesity and
   Related Metabolic Disorders (MRC-CORD).
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NR 40
TC 41
Z9 47
U1 0
U2 7
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0012-186X
EI 1432-0428
J9 DIABETOLOGIA
JI Diabetologia
PD FEB
PY 2010
VL 53
IS 2
BP 309
EP 320
DI 10.1007/s00125-009-1576-4
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 537AE
UT WOS:000273084400013
PM 19902174
OA Green Published, hybrid, Green Submitted
DA 2025-06-11
ER

PT J
AU Kontush, A
   Chapman, MJ
AF Kontush, Anatol
   Chapman, M. John
TI Functionally defective high-density lipoprotein: A new therapeutic
   target at the crossroads of dyslipidemia, inflammation, and
   atherosclerosis
SO PHARMACOLOGICAL REVIEWS
LA English
DT Review
ID APOLIPOPROTEIN-A-I; CHOLESTERYL ESTER TRANSFER; SERUM-AMYLOID-A;
   CORONARY-HEART-DISEASE; ACTIVATING-FACTOR-ACETYLHYDROLASE; ATP-BINDING
   CASSETTE; C-REACTIVE PROTEIN; ACUTE-PHASE RESPONSE; ELEVATED OXIDATIVE
   STRESS; B TYPE-I
AB High-density lipoproteins (HDL) possess key atheroprotective biological properties, including cellular cholesterol efflux capacity, and antioxidative and anti-inflammatory activities. Plasma HDL particles are highly heterogeneous in physicochemical properties, metabolism, and biological activity. Within the circulating HDL particle population, small, dense HDL particles display elevated cellular cholesterol efflux capacity, afford potent protection of atherogenic low-density lipoprotein against oxidative stress and attenuate inflammation. The antiatherogenic properties of HDL can, however be compromised in metabolic diseases associated with accelerated atherosclerosis. Indeed, metabolic syndrome and type 2 diabetes are characterized not only by elevated cardiovascular risk and by low HDL-cholesterol (HDL-C) levels but also by defective HDL function. Functional HDL deficiency is intimately associated with alterations in intravascular HDL metabolism and structure. Indeed, formation of HDL particles with attenuated antiatherogenic activity is mechanistically related to core lipid enrichment in triglycerides and cholesteryl ester depletion, altered apolipoprotein A-I (apoA-I) conformation, replacement of apoA-I by serum amyloid A, and covalent modification of HDL protein components by oxidation and glycation. Deficient HDL function and subnormal HDL-C levels may act synergistically to accelerate atherosclerosis in metabolic disease. Therapeutic normalization of attenuated antiatherogenic HDL function in terms of both particle number and quality of HDL particles is the target of innovative pharmacological approaches to HDL raising, including inhibition of cholesteryl ester transfer protein, enhanced lipidation of apoA-I with nicotinic acid and infusion of reconstituted HDL or apoA-I mimetics. A preferential increase in circulating concentrations of HDL particles possessing normalized antiatherogenic activity is therefore a promising therapeutic strategy for the treatment of common metabolic diseases featuring dyslipidemia, inflammation, and premature atherosclerosis.
C1 Hop Pitie, INSERM, Unite 551, Natl Inst Hlth & Med Res,Dyslipoproteinemia & Ath, F-75651 Paris 13, France.
C3 Sorbonne Universite; Institut National de la Sante et de la Recherche
   Medicale (Inserm); Assistance Publique Hopitaux Paris (APHP); Hopital
   Universitaire Pitie-Salpetriere - APHP
RP Kontush, A (corresponding author), Hop Pitie, INSERM, Unite 551, Natl Inst Hlth & Med Res,Dyslipoproteinemia & Ath, 83 Blvd Hop, F-75651 Paris 13, France.
EM kontush@chups.jussieu.fr
RI Kontush, Anatol/J-2198-2016; chapman, john/Y-2742-2019
OI Kontush, Anatol/0000-0002-9008-7335
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   [No title captured]
   [No title captured]
   [No title captured]
   [No title captured]
   [No title captured]
NR 461
TC 596
Z9 658
U1 1
U2 52
PU AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3995 USA
SN 0031-6997
EI 1521-0081
J9 PHARMACOL REV
JI Pharmacol. Rev.
PD SEP
PY 2006
VL 58
IS 3
BP 342
EP 374
DI 10.1124/pr.58.3.1
PG 33
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 083NW
UT WOS:000240465500002
PM 16968945
DA 2025-06-11
ER

PT J
AU Carton, T
   Thiry, C
   Wolff, F
   Corvilain, B
   Burniat, A
AF Carton, Tiphaine
   Thiry, Coralie
   Wolff, Fleur
   Corvilain, Bernard
   Burniat, Agnes
TI Impact of sweet drink on pituitary response and subject comfort during
   insulin tolerance test
SO SCIENTIFIC REPORTS
LA English
DT Article
DE Sweet drink; Insulin tolerance test; Cortisol; Growth hormone; Stress
ID GROWTH-HORMONE; ADRENAL INSUFFICIENCY; METABOLIC SYNDROME; CORTISOL
   RESPONSE; HYPOGLYCEMIA; STIMULATION; PREVALENCE; DIAGNOSIS; AGE
AB The insulin tolerance test (ITT) is the gold standard for the diagnosis of cortisol and growth hormone (GH) deficiencies. Once hypoglycemia is detected whether patients should receive carbohydrates to recover faster from hypoglycemia is controversial. The aim of our study was to assess the impact of shortening the duration of hypoglycemia by providing a sugar drink on patient comfort and hormonal responses. This prospective, single-center, crossover, single-blind study enrolled 15 healthy participants. Each subject performed two ITT: one with normal Cola and the other with Cola Zero. Glucose and hormone levels were measured at baseline and after the induction of insulin-induced hypoglycemia. Patient tolerance to ITT was evaluated using reported hypoglycemia side effects, visual analog scale scores, and quality-of-life questionnaire. Normal Cola shortened the period of hypoglycemia (plasma glucose < 40 mg/dl) from 30 to 15 min (p = 0.005), allowing a higher proportion of participants to recover from potentially dangerous values after 45 min (12 vs. 5; p = 0.008). Cola also improved patient comfort, as evaluated using a visual analog scale (VAS score 2.6 vs 3.7, p = 0.016). Sugar did not significantly change the median cortisol and GH peaks. Body mass index was the only factor determining the cortisol peak, independent of the injected insulin dose. The time to reach hormone peaks was similar between the two protocols. Cortisol and GH values were significantly higher at 120 min in the Cola Zero group, suggesting the prolongation of hypothalamic-pituitary stress in the absence of sugar. Our study confirmed that rapid correction of hypoglycemia during ITT improves subject comfort, reduces the duration of hypoglycemia and associated symptoms, while guaranteeing unchanged cortisol and GH peaks.
C1 [Carton, Tiphaine; Thiry, Coralie; Corvilain, Bernard; Burniat, Agnes] Univ Libre Bruxelles ULB, Hop Univ Bruxelles HUB, CUB Hop Erasme, Dept Endocrinol, route Lennik 808, B-1070 Brussels, Belgium.
   [Wolff, Fleur] Univ Libre Bruxelles ULB, Dept Clin Chem, LHUB ULB, Brussels, Belgium.
C3 Universite Libre de Bruxelles; Universite Libre de Bruxelles
RP Carton, T (corresponding author), Univ Libre Bruxelles ULB, Hop Univ Bruxelles HUB, CUB Hop Erasme, Dept Endocrinol, route Lennik 808, B-1070 Brussels, Belgium.
EM tiphaine.carton@hubruxelles.be
CR [Anonymous], Adult Growth Hormone Deficiency-Clinical Management-Endotext-NCBI Bookshelf
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NR 26
TC 0
Z9 0
U1 0
U2 0
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD DEC 2
PY 2024
VL 14
IS 1
AR 29973
DI 10.1038/s41598-024-81401-2
PG 10
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA P3I3R
UT WOS:001376884800031
PM 39622921
OA gold
DA 2025-06-11
ER

PT J
AU Contaifer, D
   Buckley, LF
   Wohlford, G
   Kumar, NG
   Morriss, JM
   Ranasinghe, AD
   Carbone, S
   Canada, JM
   Trankle, C
   Abbate, A
   Tassell, BW
   Wijesinghe, DS
AF Contaifer, Daniel, Jr.
   Buckley, Leo F.
   Wohlford, George
   Kumar, Naren G.
   Morriss, Joshua M.
   Ranasinghe, Asanga D.
   Carbone, Salvatore
   Canada, Justin M.
   Trankle, Cory
   Abbate, Antonio
   Van Tassell, Benjamin W.
   Wijesinghe, Dayanjan S.
TI Metabolic modulation predicts heart failure tests performance
SO PLOS ONE
LA English
DT Article
ID CARDIAC METABOLISM; PROGNOSTIC VALUE; URIC-ACID; BIOMARKERS; DISEASE;
   PLASMA; CYSTEINE; PROTEIN; STRESS; STROKE
AB The metabolic changes that accompany changes in Cardiopulmonary testing (CPET) and heart failure biomarkers (HFbio) are not well known. We undertook metabolomic and lipidomic phenotyping of a cohort of heart failure (HF) patients and utilized Multiple Regression Analysis (MRA) to identify associations to CPET and HFBio test performance (peak oxygen consumption (Peak VO2), oxygen uptake efficiency slope (OUES), exercise duration, and minute ventilation-carbon dioxide production slope (VE/VCO2 slope), as well as the established HF biomarkers of inflammation C-reactive protein (CRP), beta-galactoside-binding protein (galectin-3), and N-terminal prohormone of brain natriuretic peptide (NT-proBNP)). A cohort of 49 patients with a left ventricular ejection fraction < 50%, predominantly males African American, presenting a high frequency of diabetes, hyperlipidemia, and hypertension were used in the study. MRA revealed that metabolic models for VE/VCO2 and Peak VO2 were the most fitted models, and the highest predictors' coefficients were from Acylcarnitine C18:2, palmitic acid, citric acid, asparagine, and 3-hydroxybutiric acid. Metabolic Pathway Analysis (MetPA) used predictors to identify the most relevant metabolic pathways associated to the study, aminoacyl-tRNA and amino acid biosynthesis, amino acid metabolism, nitrogen metabolism, pantothenate and CoA biosynthesis, sphingolipid and glycerolipid metabolism, fatty acid biosynthesis, glutathione metabolism, and pentose phosphate pathway (PPP). Metabolite Set Enrichment Analysis (MSEA) found associations of our findings with pre-existing biological knowledge from studies of human plasma metabolism as brain dysfunction and enzyme deficiencies associated with lactic acidosis. Our results indicate a profile of oxidative stress, lactic acidosis, and metabolic syndrome coupled with mitochondria dysfunction in patients with HF tests poor performance. The insights resulting from this study coincides with what has previously been discussed in existing literature thereby supporting the validity of our findings while at the same time characterizing the metabolic underpinning of CPET and HFBio.
C1 [Contaifer, Daniel, Jr.; Buckley, Leo F.; Wohlford, George; Kumar, Naren G.; Morriss, Joshua M.; Van Tassell, Benjamin W.; Wijesinghe, Dayanjan S.] Virginia Commonwealth Univ, Sch Pharm, Dept Pharmacotherapy & Outcomes Sci, Richmond, VA 23284 USA.
   [Kumar, Naren G.] Virginia Commonwealth Univ, Sch Med, Dept Microbiol, Richmond, VA USA.
   [Ranasinghe, Asanga D.] Amarillo Coll, Dept Phys & Biol Sci, Amarillo, TX USA.
   [Carbone, Salvatore; Canada, Justin M.; Trankle, Cory; Abbate, Antonio] Virginia Commonwealth Univ, Pauley Heart Ctr, Richmond, VA USA.
   [Abbate, Antonio] Virginia Commonwealth Univ, Sch Med, Dept Internal Med, Richmond, VA USA.
   [Wijesinghe, Dayanjan S.] Virginia Commonwealth Univ, Da Vinci Ctr, Richmond, VA 23284 USA.
   [Wijesinghe, Dayanjan S.] Virginia Commonwealth Univ, Sch Pharm, ISB3D, Richmond, VA 23284 USA.
C3 Virginia Commonwealth University; Virginia Commonwealth University;
   Amarillo College; Virginia Commonwealth University; Virginia
   Commonwealth University; Virginia Commonwealth University; Virginia
   Commonwealth University
RP Tassell, BW; Wijesinghe, DS (corresponding author), Virginia Commonwealth Univ, Sch Pharm, Dept Pharmacotherapy & Outcomes Sci, Richmond, VA 23284 USA.; Wijesinghe, DS (corresponding author), Virginia Commonwealth Univ, Da Vinci Ctr, Richmond, VA 23284 USA.; Wijesinghe, DS (corresponding author), Virginia Commonwealth Univ, Sch Pharm, ISB3D, Richmond, VA 23284 USA.
EM bvantassell@vcu.edu; wijesingheds@vcu.edu
RI Morris, Joshua/GQB-1454-2022; Kumar, Naren/AFH-3198-2022; Carbone,
   Salvatore/J-2830-2019; Abbate, Antonio/G-8805-2016; Wohlford,
   George/AAH-2838-2019; Buckley, Leo/P-8434-2014
OI Contaifer Junior, Daniel/0000-0002-3165-4192; Carbone,
   Salvatore/0000-0002-8163-0527; Wohlford, George/0000-0002-5670-7916;
   Gajenthra Kumar, Naren/0000-0001-7248-6351
FU National Institutes of Health [HD087198, HL117026]; Heart Failure
   Society of America; SCIEX
FX Research reported in this publication was supported by research grants
   from National Institutes of Health under grant numbers HD087198 (to
   DSW), HL117026 (to BVT, AA) and from the Heart Failure Society of
   America (to LFB). The content is solely the responsibility of the
   authors and does not necessarily represent the official views of the
   National Institutes of Health. This work also received support via a
   Young Investigator Award from SCIEX for clinical lipidomic research
   (DSW).
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NR 57
TC 17
Z9 19
U1 0
U2 8
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JUN 20
PY 2019
VL 14
IS 6
AR e0218153
DI 10.1371/journal.pone.0218153
PG 20
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA IW3PH
UT WOS:000484893500025
PM 31220103
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Espinoza-Derout, J
   Shao, XM
   Bankole, E
   Hasan, KM
   Mtume, N
   Liu, YJ
   Sinha-Hikim, AP
   Friedman, TC
AF Espinoza-Derout, Jorge
   Shao, Xuesi M.
   Bankole, Emmanuel
   Hasan, Kamrul M.
   Mtume, Norma
   Liu, Yanjun
   Sinha-Hikim, Amiya P.
   Friedman, Theodore C.
TI Hepatic DNA Damage Induced by Electronic Cigarette Exposure Is
   Associated With the Modulation of NAD+/PARP1/SIRT1 Axis
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Article
DE reactive oxygen species; DNA damage; hepatic metabolism; mitochondria;
   NAD
ID HIGH-FAT DIET; POLY(ADP-RIBOSE) POLYMERASE; MITOCHONDRIAL-FUNCTION;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; NICOTINE; STEATOSIS; REPAIR;
   LIVER; QUANTIFICATION
AB The prevalence of electronic cigarette (e-cigarettes) use has rapidly increased worldwide. Use of tobacco products has been associated with DNA damage and metabolic syndrome. Using Apolipoprotein E knockout (ApoE(-/-)) mice on a western diet (WD), a mouse model of non-alcoholic fatty liver disease (NAFLD), we recently demonstrated that nicotine in e-cigarettes activates hepatocyte apoptosis, and causes hepatic steatosis. This study examines the harmful effects of e-cigarettes on the liver with a special emphasis on DNA damage and mitochondrial dysfunction. ApoE(-/- )mice were exposed to saline, e-cigarettes without nicotine or e-cigarettes with 2.4% nicotine for 12 weeks using our newly developed mouse e-cigarette exposure model system that delivers nicotine to mice leading to equivalent serum cotinine levels found in human cigarette users. Mice exposed to e-cigarette (2.4% nicotine) had increased apurinic/apyrimidinic (AP) sites, a manifestation of DNA damage. Additionally, e-cigarette (2.4% nicotine) produced a decrease in NAD+/NADH ratio and increased oxidative stress in hepatic cells, in comparison with saline and e-cigarette (0%). Western blot analysis showed that mice treated with e-cigarette (2.4% nicotine) had increased poly (ADP ribose) polymerase (PARP1) activity associated with reduced levels of Sirtuin 1 (SIRT1). Furthermore, mitochondrial DNA mutations and PTEN-induced kinase 1 (PINK1) were increased in mice treated with e-cigarette (2.4% nicotine). Transmission electron microscopy revealed that hepatocytes of mice treated with e-cigarette (2.4% nicotine) exhibited increased vacuolization of the mitochondria and a reduction in cellular organelles. These results demonstrate the adverse effects of e-cigarettes exposure leading to NAD+ deficiency which may suggest a mechanistic link between e-cigarette-induced hepatic DNA damage and mitochondrial dysfunction.
C1 [Espinoza-Derout, Jorge; Shao, Xuesi M.; Bankole, Emmanuel; Hasan, Kamrul M.; Mtume, Norma; Liu, Yanjun; Sinha-Hikim, Amiya P.; Friedman, Theodore C.] Charles R Drew Univ Med & Sci, Dept Internal Med, Div Endocrinol Metab & Mol Med, 1621 E 120th St, Los Angeles, CA 90059 USA.
   [Shao, Xuesi M.; Liu, Yanjun; Sinha-Hikim, Amiya P.; Friedman, Theodore C.] Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90095 USA.
C3 Charles R. Drew University of Medicine & Science; University of
   California System; University of California Los Angeles; University of
   California Los Angeles Medical Center; David Geffen School of Medicine
   at UCLA
RP Espinoza-Derout, J (corresponding author), Charles R Drew Univ Med & Sci, Dept Internal Med, Div Endocrinol Metab & Mol Med, 1621 E 120th St, Los Angeles, CA 90059 USA.
EM jorgeespinozaderout@cdrewu.edu
RI 刘, 严君/GZL-5764-2022; Shao, Max/HKW-4718-2023; hasan,
   kamrul/HGV-0910-2022
FU Diversity-Promoting Institution Drug Abuse Research Program (DIDARP)
   [R24DA017298]; Accelerating Excellence in Translational Science (AXIS)
   from the National Institutes of Health (NIH) [5U54MD007598]; California
   Tobacco-Related Disease Research Program (TRDRP) [251P003]; NIH
   [SC1DK104821]; NIDA/NIH [1R41DA044788-01]
FX This work was supported by the Diversity-Promoting Institution Drug
   Abuse Research Program (DIDARP) grant (R24DA017298); a pilot project
   grant and vouchers from the Accelerating Excellence in Translational
   Science (AXIS) grant (5U54MD007598) from the National Institutes of
   Health (NIH); and California Tobacco-Related Disease Research Program
   (TRDRP) Grant 251P003. YL is supported by NIH grant SC1DK104821. XS is
   supported by NIDA/NIH grant 1R41DA044788-01.
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NR 54
TC 31
Z9 35
U1 0
U2 16
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD JUN 4
PY 2019
VL 10
AR 320
DI 10.3389/fendo.2019.00320
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA IB2TY
UT WOS:000470122800001
PM 31214115
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Alicka, M
   Major, P
   Wysocki, M
   Marycz, K
AF Alicka, Michalina
   Major, Piotr
   Wysocki, Michal
   Marycz, Krzysztof
TI Adipose-Derived Mesenchymal Stem Cells Isolated from Patients with Type
   2 Diabetes Show Reduced "Stemness" through an Altered Secretome Profile,
   Impaired Anti-Oxidative Protection, and Mitochondrial Dynamics
   Deterioration
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Article
DE adipose-derived mesenchymal stem cells; type 2 diabetes; extracellular
   microvesicle; insulin resistance; regenerative medicine
ID METABOLIC SYNDROME; OXIDATIVE STRESS; BONE-MARROW; DIFFERENTIATION;
   PROLIFERATION; CONTRIBUTES; TELOMERE; HYPOXIA; MARKER; SIRT1
AB The widespread epidemic of obesity and type 2 diabetes (T2D), suggests that both disorders are closely linked. Several pre-clinical and clinical studies have showed that adipose-derived mesenchymal stem cells (ASC) transplantation is efficient and safe. Moreover, scientists have already highlighted the therapeutic capacity of their secretomes. In this study, we used quantitative PCR, a flow cytometry-based system, the ELISA method, spectrophotometry, and confocal and scanning electron microscopy, to compare the differences in proliferation activity, viability, morphology, mitochondrial dynamics, mRNA and miRNA expression, as well as the secretory activity of ASCs derived from two donor groups-non-diabetic and T2D patients. We demonstrated that ASCs from T2D patients showed a reduced viability and a proliferative potential. Moreover, they exhibited mitochondrial dysfunction and senescence phenotype, due to excessive oxidative stress. Significant differences were observed in the expressions of miRNA involved in cell proliferations (miR-16-5p, miR-146a-5p, and miR-145-5p), as well as miRNA and genes responsible for glucose homeostasis and insulin sensitivity (miR-24-3p, 140-3p, miR-17-5p, SIRT1, HIF-1 alpha, LIN28, FOXO1, and TGF beta). We have observed a similar correlation of miR-16-5p, miR-146a-5p, miR-24-3p, 140-3p, miR-17-5p, and miR-145-5p expression in extracellular vesicles fraction. Furthermore, we have shown that ASC(T2D) exhibited a lower VEGF, adiponectin, and CXCL-12 secretion, but showed an overproduction of leptin. We have shown that type 2 diabetes attenuated crucial functions of ASC, like proliferation, viability, and secretory activity, which highly reduced their therapeutic efficiency.
C1 [Alicka, Michalina; Marycz, Krzysztof] Wroclaw Univ Environm & Life Sci, Dept Expt Biol, Norwida 27B, PL-50365 Wroclaw, Poland.
   [Major, Piotr; Wysocki, Michal] Jagiellonian Univ, Dept Gen Surg 2, Med Coll, Kopernika 21, PL-31501 Krakow, Poland.
   [Marycz, Krzysztof] Justus Liebig Univ, Fac Vet Med, Equine Clin Equine Surg, D-35392 Giessen, Germany.
   [Marycz, Krzysztof] Int Inst Translat Med, Jesionowa 11, PL-55114 Malin, Wisznia Mala, Poland.
C3 Wroclaw University of Environmental & Life Sciences; Jagiellonian
   University; Collegium Medicum Jagiellonian University; Justus Liebig
   University Giessen
RP Marycz, K (corresponding author), Wroclaw Univ Environm & Life Sci, Dept Expt Biol, Norwida 27B, PL-50365 Wroclaw, Poland.; Marycz, K (corresponding author), Justus Liebig Univ, Fac Vet Med, Equine Clin Equine Surg, D-35392 Giessen, Germany.; Marycz, K (corresponding author), Int Inst Translat Med, Jesionowa 11, PL-55114 Malin, Wisznia Mala, Poland.
EM michalina.alicka@upwr.edu.pl; piotr.major@uj.edu.pl;
   m.wysocki@doctoral.uj.edu.pl; krzysztofmarycz@interia.pl
RI Alicka, Michalina/AGZ-1134-2022
OI Alicka, Michalina/0000-0002-6717-9864; Marycz,
   Krzysztof/0000-0003-3676-796X; Major, Piotr/0000-0001-6552-7979
FU National Science Centre in Poland [2018/29/B/NZ7/02662]
FX This work was supported by a grant from the National Science Centre in
   Poland, over the course of the realization of the project: 'Inhibition
   of tyrosine phosphatase as a strategy to enhance insulin sensitivity
   through the activation of chaperone-mediated autophagy and amelioration
   of inflammation and cellular stress in the liver of equine metabolic
   syndrome (EMS) horses.' (2018/29/B/NZ7/02662).
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NR 58
TC 84
Z9 88
U1 0
U2 12
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD JUN
PY 2019
VL 8
IS 6
AR 765
DI 10.3390/jcm8060765
PG 19
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA II7CG
UT WOS:000475349300009
PM 31151180
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Sukumaran, V
   Tsuchimochi, H
   Sonobe, T
   Shirai, M
   Pearson, JT
AF Sukumaran, Vijayakumar
   Tsuchimochi, Hirotsugu
   Sonobe, Takashi
   Shirai, Mikiyasu
   Pearson, James T.
TI Liraglutide Improves Renal Endothelial Function in Obese Zucker Rats on
   a High-Salt Diet
SO JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
LA English
DT Article
ID GLUCAGON-LIKE PEPTIDE-1; SPONTANEOUSLY HYPERTENSIVE-RATS; INDUCED
   DIABETIC-RATS; OXIDATIVE STRESS; INSULIN-RESISTANCE; GENE-EXPRESSION;
   UP-REGULATION; NITRIC-OXIDE; INHIBITION; RECEPTOR
AB Metabolic syndrome is a common risk factor in chronic kidney disease. We investigated whether liraglutide [(LIRA), a glucagon-like peptide-1 receptor (GLP-1R) agonist] treatment improved renal vascular function and renal remodeling in male Zucker rats on a high-salt diet (6% NaCl). Zucker lean (+/+) and obese (fa/fa) rats (8 weeks old) were treated with vehicle or LIRA (0.1 mg/kg per day) for 8 weeks on a high-salt diet. The glomerular filtration rate (GFR) was measured at 0 and 8 weeks using the fluorescein isothiocyanate/sinistrin method in conscious rats. We used X-ray microangiography to measure renal arterial vessel diameter (70-350 mu m) and vessel number in vivo in anesthetized rats. Renal protein expression levels of nitrotyrosine, CD-68, endothelial nitric oxide synthase (eNOS), vascular endothelial growth factor (VEGF), transforming growth factor-beta 1, cyclooxygenase-2, and GLP-1R were assessed by western blotting. Renal gene expressions were determined by real-time polymerase chain reaction. In contrast to vehicle-treated rats, fa/fa-LIRA rats improved GFR, nitric oxide (NO)mediated vasodilation in response to acetylcholine and sodium nitroprusside in small arterial vessels (<200 mu m diameter). LIRA treatment increased vessel responsivity to NO donors in comparison with vehicle treatment. Increases in the expressions of proinflammatory, profibrotic, and oxidative stress related genes in fa/fa rats relative to +/+ were unaltered by LIRA, other than a trend toward attenuation of VCAM-1 gene expression. However, LIRA treatment increased protein expressions of eNOS (P = 0.014) and VEGF (P = 0.063), while reducing glomerular macrophage infiltration in comparison with vehicle-treated fa/fa rats. Low-dose LIRA treatment improved renal vascular function through amelioration of vascular dysfunction and improved NO-mediated dilation of small intrarenal arteries and arterioles and a reduction in renal inflammation.
C1 [Sukumaran, Vijayakumar; Tsuchimochi, Hirotsugu; Sonobe, Takashi; Pearson, James T.] Natl Cerebral & Cardiovasc Ctr, Res Inst, Dept Cardiac Physiol, Suita, Osaka 5658565, Japan.
   [Shirai, Mikiyasu] Natl Cerebral & Cardiovasc Ctr, Res Inst, Ctr Adv Med Res Pulm Hypertens, Suita, Osaka, Japan.
   [Pearson, James T.] Monash Univ, Dept Physiol, Monash Biomed Discovery Inst, Clayton, Vic, Australia.
C3 National Cerebral & Cardiovascular Center - Japan; National Cerebral &
   Cardiovascular Center - Japan; Monash University
RP Sukumaran, V (corresponding author), Natl Cerebral & Cardiovasc Ctr, Res Inst, Dept Cardiac Physiol, Suita, Osaka 5658565, Japan.
EM sukumaran.vijayakumar09@ncvc.go.jp
RI Sonobe, Takashi/Q-6600-2016; Tsuchimochi, Hirotsugu/D-8224-2011;
   Sukumaran, Vijayakumar/K-8523-2015; Pearson, James/B-4631-2012
OI Pearson, James/0000-0002-3318-5406; VIJAYAKUMAR,
   SUKUMARAN/0000-0002-2686-7329
FU Novo Nordisk Pharma Ltd.
FX This Research was supported financially as an investigator sponsored
   study by Novo Nordisk Pharma Ltd., an affiliate of Novo Nordisk A/S of
   Denmark.
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NR 51
TC 16
Z9 16
U1 0
U2 3
PU AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3995 USA
SN 0022-3565
EI 1521-0103
J9 J PHARMACOL EXP THER
JI J. Pharmacol. Exp. Ther.
PD JUN 1
PY 2019
VL 369
IS 3
BP 375
EP 388
DI 10.1124/jpet.118.254821
PG 14
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA IA0JI
UT WOS:000469242500007
PM 30910920
OA Bronze
DA 2025-06-11
ER

PT J
AU Clemente, MG
   Mandato, C
   Poeta, M
   Vajro, P
AF Clemente, Maria Grazia
   Mandato, Claudia
   Poeta, Marco
   Vajro, Pietro
TI Pediatric non-alcoholic fatty liver disease: Recent solutions,
   unresolved issues, and future research directions
SO WORLD JOURNAL OF GASTROENTEROLOGY
LA English
DT Review
DE Non-alcoholic fatty liver disease; Childhood obesity; Non-alcoholic
   steatohepatitis; Hepatic metabolic syndrome; Non-alcoholic fatty liver
   disease diagnosis
ID GROWTH-HORMONE REPLACEMENT; OBESE CHILDREN; VITAMIN-E;
   INSULIN-RESISTANCE; HEPATIC FAT; DOCOSAHEXAENOIC ACID; SLEEVE
   GASTRECTOMY; LIPID-METABOLISM; POSITION PAPER; RISK-FACTORS
AB Non-alcoholic fatty liver disease (NAFLD) in children is becoming a major health concern. A "multiple-hit" pathogenetic model has been suggested to explain the progressive liver damage that occurs among children with NAFLD. In addition to the accumulation of fat in the liver, insulin resistance (IR) and oxidative stress due to genetic/epigenetic background, unfavorable lifestyles, gut microbiota and gut-liver axis dysfunction, and perturbations of trace element homeostasis have been shown to be critical for disease progression and the development of more severe inflammatory and fibrotic stages [non-alcoholic steatohepatitis (NASH)]. Simple clinical and laboratory parameters, such as age, history, anthropometrical data (BMI and waist circumference percentiles), blood pressure, surrogate clinical markers of IR (acanthosis nigricans), abdominal ultrasounds, and serum transaminases, lipids and glucose/insulin profiles, allow a clinician to identify children with obesity and obesity-related conditions, including NAFLD and cardiovascular and metabolic risks. A liver biopsy (the "imperfect" gold standard) is required for a definitive NAFLD/NASH diagnosis, particularly to exclude other treatable conditions or when advanced liver disease is expected on clinical and laboratory grounds and preferably prior to any controlled trial of pharmacological/surgical treatments. However, a biopsy clearly cannot represent a screening procedure. Advancements in diagnostic serum and imaging tools, especially for the non-invasive differentiation between NAFLD and NASH, have shown promising results, e.g., magnetic resonance elastography. Weight loss and physical activity should be the first option of intervention. Effective pharmacological treatments are still under development; however, drugs targeting IR, oxidative stress, proinflammatory pathways, dyslipidemia, gut microbiota and gut liver axis dysfunction are an option for patients who are unable to comply with the recommended lifestyle changes. When morbid obesity prevails, bariatric surgery should be considered.
C1 [Clemente, Maria Grazia] Univ Sassari, Dept Surg Microsurg & Med Sci, Pediat Clin, I-07100 Sassari, Italy.
   [Mandato, Claudia] Pediat AORN Santobono Pausilipon, I-80123 Naples, Italy.
   [Poeta, Marco; Vajro, Pietro] Univ Salerno, Dept Med Surg & Dent Scuola Med Salernitana, Pediat, Via Allende, I-84081 Baronissi, Italy.
   [Vajro, Pietro] ELFID European Lab Invest Food Induced Dis, I-80138 Naples, Italy.
C3 University of Sassari; University of Salerno
RP Vajro, P (corresponding author), Univ Salerno, Dept Med Surg & Dent Scuola Med Salernitana, Pediat, Via Allende, I-84081 Baronissi, Italy.
EM pvajro@unisa.it
RI Clemente, Maria/I-3668-2019; Vajro, Pietro/H-5179-2019; Poeta,
   Marco/AAL-8522-2020; Mandato, Claudia/G-6367-2018; Mandato,
   Claudia/B-2760-2018
OI Clemente, Maria Grazia/0000-0002-4586-3868; Poeta,
   Marco/0000-0002-7515-1394; Mandato, Claudia/0000-0003-2425-5449
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NR 117
TC 134
Z9 146
U1 0
U2 31
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 7041 Koll Center Parkway, Suite 160, PLEASANTON, CA, UNITED STATES
SN 1007-9327
EI 2219-2840
J9 WORLD J GASTROENTERO
JI World J. Gastroenterol.
PD SEP 28
PY 2016
VL 22
IS 36
BP 8078
EP 8093
DI 10.3748/wjg.v22.i36.8078
PG 16
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA DW9LY
UT WOS:000383982700003
PM 27688650
OA hybrid, Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Oda, E
AF Oda, Eiji
TI Cross-sectional and longitudinal associations between serum bilirubin
   and dyslipidemia in a health screening population
SO ATHEROSCLEROSIS
LA English
DT Article
DE Bilirubin; Triglycerides; HDL cholesterol; Oxidative stress
ID CORONARY-HEART-DISEASE; METABOLIC SYNDROME; GILBERTS-SYNDROME; OXIDATIVE
   STRESS; CARDIOVASCULAR PROTECTION; RISK-FACTOR; MEN; ANTIOXIDANT;
   RESISTANCE; CHILDREN
AB Objective: To investigate cross-sectional and longitudinal associations between serum total bilirubin (TB) and dyslipidemia.
   Methods: Odds ratios (ORs) of prevalent dyslipidemia for TB were calculated in 2113 men and 1265 women. Correlation coefficients between baseline TB as well as the change in TB over 5 years and baseline log triglycerides, baseline HDL cholesterol and the changes in log triglycerides and HDL cholesterol over 5 years were calculated. Hazard ratios (HRs) of incident hypertriglyceridemia and hypo-HDL cholesterolemia for TB over 5 years were calculated in 1324 men and 915 women and 1583 men and 884 women, respectively.
   Results: The ORs of prevalent hypertriglyceridemia and hypo-HDL cholesterolemia for each one SD increase in TB were 0.83 (p < 0.001) in men and 0.71 (p = 0.074) in women and 0.64 (p < 0.001) in men and 0.78 (p = 0.089) in women, respectively adjusted for age, smoking, and other confounders. The baseline TB was significantly correlated with baseline log triglycerides and HDL cholesterol both in men and women while the change in TB was significantly correlated with the changes in log triglycerides and HDL cholesterol in men and the change in HDL cholesterol in women. The HRs of incident hypertriglyceridemia and hypo-HDL cholesterolemia for each one SD increase in TB were 0.99 (p = 0.848) in men and 0.74 (p = 0.033) in women and 1.08 (p = 0.345) in men and 0.85 (p = 0.220) in women, respectively adjusted for age, smoking, and other confounders.
   Conclusion: Baseline TB was significantly associated with both prevalent hypertriglyceridemia and hypo-HDL cholesterolemia in men and with incident hypertriglyceridemia in women. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
C1 Tachikawa Med Ctr, Med Check Up Ctr, Nagaoka, Niigata 9400053, Japan.
RP Oda, E (corresponding author), Tachikawa Med Ctr, Med Check Up Ctr, Nagachou 2-2-16, Nagaoka, Niigata 9400053, Japan.
EM ijie@venus.sannet.ne.jp
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NR 36
TC 10
Z9 10
U1 0
U2 7
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0021-9150
EI 1879-1484
J9 ATHEROSCLEROSIS
JI Atherosclerosis
PD MAR
PY 2015
VL 239
IS 1
BP 31
EP 37
DI 10.1016/j.atherosclerosis.2014.12.053
PG 7
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA CB6RH
UT WOS:000349753800005
PM 25568950
DA 2025-06-11
ER

PT J
AU Riso, P
   Klimis-Zacas, D
   Del Bo', C
   Martini, D
   Campolo, J
   Vendrame, S
   Moller, P
   Loft, S
   De Maria, R
   Porrini, M
AF Riso, Patrizia
   Klimis-Zacas, Dorothy
   Del Bo', Cristian
   Martini, Daniela
   Campolo, Jonica
   Vendrame, Stefano
   Moller, Peter
   Loft, Steffen
   De Maria, Renata
   Porrini, Marisa
TI Effect of a wild blueberry (Vaccinium angustifolium) drink
   intervention on markers of oxidative stress, inflammation and
   endothelial function in humans with cardiovascular risk factors
SO EUROPEAN JOURNAL OF NUTRITION
LA English
DT Article
DE Wild blueberry; Endothelial function; DNA damage; Blood lipids;
   Cardiovascular risk
ID CROSS-SECTIONAL RELATIONS; FLAVANOL-RICH COCOA; PHASE-II ENZYMES;
   VASCULAR FUNCTION; DNA-DAMAGE; DEPENDENT VASODILATION; METABOLIC
   SYNDROME; JUICE; CONSUMPTION; WOMEN
AB Wild blueberries (WB) (Vaccinium angustifolium) are rich sources of polyphenols, such as flavonols, phenolic acids and anthocyanins (ACNs), reported to decrease the risk of cardiovascular and degenerative diseases. This study investigated the effect of regular consumption of a WB or a placebo (PL) drink on markers of oxidative stress, inflammation and endothelial function in subjects with risk factors for cardiovascular disease.
   Eighteen male volunteers (ages 47.8 +/- A 9.7 years; body mass index 24.8 +/- A 2.6 kg/m(2)) received according to a cross-over design, a WB (25 g freeze-dried powder, providing 375 mg of ACNs) or a PL drink for 6 weeks, spaced by a 6-week wash-out. Endogenous and oxidatively induced DNA damage in blood mononuclear cells, serum interleukin levels, reactive hyperemia index, nitric oxide, soluble vascular adhesion molecule concentration and other variables were analyzed.
   Wild blueberry drink intake significantly reduced the levels of endogenously oxidized DNA bases (from 12.5 +/- A 5.6 % to 9.6 +/- A 3.5 %, p a parts per thousand currency sign 0.01) and the levels of H2O2-induced DNA damage (from 45.8 +/- A 7.9 % to 37.2 +/- A 9.1 %, p a parts per thousand currency sign 0.01), while no effect was found after the PL drink. No significant differences were detected for markers of endothelial function and the other variables under study.
   In conclusion, the consumption of the WB drink for 6 weeks significantly reduced the levels of oxidized DNA bases and increased the resistance to oxidatively induced DNA damage. Future studies should address in greater detail the role of WB in endothelial function. This study was registered at www.isrctn.org as ISRCTN47732406.
C1 [Riso, Patrizia; Del Bo', Cristian; Martini, Daniela; Porrini, Marisa] Univ Milan, Dept Food Environm & Nutr Sci, DeFENS, I-20133 Milan, Italy.
   [Klimis-Zacas, Dorothy; Vendrame, Stefano] Univ Maine, Dept Food Sci & Human Nutr, Orono, ME USA.
   [Campolo, Jonica; De Maria, Renata] Osped Niguarda Ca Granda, CNR, Ist Fisiol Clin, Dipartimento Cardiovasc, Milan, Italy.
   [Moller, Peter; Loft, Steffen] Univ Copenhagen, Dept Publ Hlth, Environm Hlth Sect, Copenhagen, Denmark.
C3 University of Milan; University of Maine System; University of Maine
   Orono; IRCCS Ca Granda Ospedale Maggiore Policlinico; Ospedale Niguarda
   Ca' Granda; Consiglio Nazionale delle Ricerche (CNR); University of
   Copenhagen
RP Riso, P (corresponding author), Univ Milan, Dept Food Environm & Nutr Sci, DeFENS, Via Celoria 2, I-20133 Milan, Italy.
EM patrizia.riso@unimi.it
RI Campolo, Jonica/ABC-5841-2020; Martini, Daniela/S-2499-2019; Del Bò,
   Cristian/AFT-1534-2022; Riso, Patrizia/AAC-2072-2019; porrini,
   marisa/AAF-6788-2021; De Maria, Renata/I-9065-2012; martini,
   daniela/D-6241-2015
OI De Maria, Renata/0000-0002-8474-7923; Loft, Steffen/0000-0001-9552-8518;
   Riso, Patrizia/0000-0002-9204-7257; martini,
   daniela/0000-0001-8298-926X; porrini, marisa/0000-0003-2693-3311; DEL
   BO', CRISTIAN/0000-0001-7562-377X
FU Cariplo Foundation (Milan, Italy) [2007-5810]
FX This work was supported by a research grant (2007-5810) from the Cariplo
   Foundation (Milan, Italy) and by a contribution of the freeze-dried wild
   blueberry powder from the Wild Blueberry Association of North America
   (WBANA) and Future Ceuticals (Momence, IL, USA). We are grateful to F.
   Hoffmann-LaRoche for the gift of the photosensitizer. The funders and
   donors had no role in study design, data collection and analysis,
   decision to publish, or preparation of the manuscript. We are grateful
   to the medical staff of AVIS (Associazione Italiani Volontari Sangue,
   via Edoardo Bassini 26, 20133 Milan, Italy), in particular Drs. Galastri
   and Verducci for their commendable support. We thank Dr. Marina Parolini
   (Istituto di Fisiologia Clinica CNR, Dipartimento Cardiovascolare,
   Ospedale Niguarda Ca' Granda, Milan, Italy) for supervision of the
   statistical analysis. Moreover, we are grateful to all the volunteers
   who participated in the study for their time and effort.
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NR 59
TC 215
Z9 237
U1 0
U2 110
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1436-6207
EI 1436-6215
J9 EUR J NUTR
JI Eur. J. Nutr.
PD APR
PY 2013
VL 52
IS 3
BP 949
EP 961
DI 10.1007/s00394-012-0402-9
PG 13
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 119DY
UT WOS:000317078900010
PM 22733001
DA 2025-06-11
ER

PT J
AU Dufour, S
   Petersen, KF
AF Dufour, Sylvie
   Petersen, Kitt Falk
TI Disassociation of Liver and Muscle Insulin Resistance from Ectopic Lipid
   Accumulation in Low-Birth-Weight Individuals
SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Article
ID SKELETAL-MUSCLE; YOUNG MEN; SUBSTRATE OXIDATION; METABOLIC SYNDROME;
   GLUCOSE-PRODUCTION; DIABETES-MELLITUS; HEPATIC STEATOSIS; FETAL GROWTH;
   OBESE WOMEN; ADULT LIFE
AB Context: Low birth weight (LBW) is a marker of fetal stress and is associated with an increased prevalence of type 2 diabetes (T2D). Insulin resistance plays a prominent role in the development of T2D; however, the pathogenesis of T2D in LBW is controversial.
   Objective: The objective of the study was to assess whole-body and tissue-specific insulin sensitivity and intramyocellular lipid (IMCL) and hepatic lipid content in LBW and matched control subjects.
   Design: These were prospective and pair-matched studies.
   Setting: The study was conducted at Yale University Center for Clinical Investigation.
   Participants: Young, lean, nonsmoking, sedentary LBW (n = 45) and matched control subjects participated in the study. Intervention: Interventions included an oral glucose tolerance test and hyperinsulinemic-euglycemic clamps and H-1 magnetic resonance spectroscopy.
   Main Outcomes Measures: The main outcomes measures included insulin sensitivity index; whole-body and tissue-specific insulin sensitivity; liver lipid and IMCL contents; and fasting concentrations of cortisol, GH, and IGF-I as markers of the hypothalamic-pituitary-adrenal and IGFI/GH axes.
   Results: The LBW subjects were insulin resistant as reflected by a 20% reduction in insulin sensitivity index as compared with the controls (P = 0.0017), which could be attributed to both liver and muscle insulin resistance. There were no differences in IMCL or hepatic triglyceride content between LBW and control groups. In the LBW group, fasting plasma concentrations of cortisol (P = 0.01) and GH (P = 0.01) were increased, and IGF-I concentrations reduced (P < 0.05) a pattern, which may suggest potential dysregulation of the hypothalamic-pituitary-adrenal and IGF-I/GH axes.
   Conclusion: These results support the hypothesis that fetal stress and LBW lead to liver and muscle insulin resistance and show that this is independent of lipid deposition in these organs. (J Clin Endocrinol Metab 96: 3873-3880, 2011)
C1 [Petersen, Kitt Falk] Yale Univ, Sch Med, Dept Internal Med, Endocrinol Sect, New Haven, CT 06520 USA.
   [Dufour, Sylvie] Yale Univ, Sch Med, Howard Hughes Med Inst, New Haven, CT 06520 USA.
C3 Yale University; Yale University; Howard Hughes Medical Institute
RP Petersen, KF (corresponding author), Yale Univ, Sch Med, Dept Internal Med, Endocrinol Sect, POB 208020, New Haven, CT 06520 USA.
EM kitt.petersen@yale.edu
FU Public Health Service [R01 AG-23686, R01 DK-49230, UL1 RR-024139, P30
   DK-45735]; American Diabetes Association
FX This work was supported by Grants R01 AG-23686, R01 DK-49230, UL1
   RR-024139, and P30 DK-45735 from the Public Health Service and a
   Distinguished Clinical Scientist Award from the American Diabetes
   Association (to K.F.P.). The funders had no role in study design, data
   collection and analysis, decision to publish, or preparation of the
   manuscript.
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NR 42
TC 14
Z9 14
U1 0
U2 3
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0021-972X
EI 1945-7197
J9 J CLIN ENDOCR METAB
JI J. Clin. Endocrinol. Metab.
PD DEC
PY 2011
VL 96
IS 12
BP 3873
EP 3880
DI 10.1210/jc.2011-1747
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 865FA
UT WOS:000298295200063
PM 21994962
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Safwat, GM
   Pisanó, S
   D'Amore, E
   Borioni, G
   Napolitano, M
   Kamal, AA
   Ballanti, P
   Botham, KM
   Bravo, E
AF Safwat, Ghada M.
   Pisano, Stefania
   D'Amore, Emanuela
   Borioni, Giorgio
   Napolitano, Mariarosaria
   Kamal, Adel Amin
   Ballanti, Paola
   Botham, Kathleen M.
   Bravo, Elena
TI Induction of non-alcoholic fatty liver disease and insulin resistance by
   feeding a high-fat diet in rats: does coenzyme Q monomethyl ether have a
   modulatory effect?
SO NUTRITION
LA English
DT Article
DE Hepatic steatosis; Coenzyme Q9; Oxidative stress; Antioxidant; Diabetes;
   Triacylglycerol
ID LIPID-PEROXIDATION; HEPATIC STEATOSIS; OXIDATIVE STRESS; METABOLIC
   SYNDROME; ANIMAL-MODELS; RISK-FACTORS; STEATOHEPATITIS; MITOCHONDRIAL;
   LEPTIN; ANTIOXIDANTS
AB Objective: The aim of this study was to investigate the development of non-alcoholic fatty liver disease (NAFLD) in response to a high-fat diet in rats and to test the hypothesis that dietary coenzyme Q monomethyl ether (CoQme) has antisteatogenic effects.
   Methods: Rats were fed a standard low-fat diet (control) for 18 wk or a diet containing 35% fat (57% metabolizable energy) for 10 wk, then divided into three groups for the following 8 wk. One group was given CoQ9me (30 mg/kg body weight per day in 0.3 mL olive oil: high fat + CoQ9me), the second olive oil (0.3 mL/d) only (high fat + olive oil), and the third group received no supplements (high fat).
   Results: Insulin levels and the activity of alanine aminotransferase in the plasma were significantly increased in all high-fat diet groups, and the homeostasis model assessment of insulin resistance indicated insulin resistance. Triacylglycerol concentrations in whole plasma and in very low-density lipoprotein and low-density lipoprotein fractions were also raised. Liver histology showed lipid accumulation in animals fed the high-fat diets, and liver triacylglycerol levels were increased (2.5- to 3-fold) in all high-fat diet groups. These effects were not changed by the administration of CoQ9me.
   Conclusions: Rats fed a diet with 57% energy from fat showed insulin resistance, hypertriglyceridemia, increased very low-density lipoprotein production, hepatic steatosis, and liver damage, and thus provide a good model for the early stages of NAFLD. Dietary CoQ9me, however, did not ameliorate the damaging effects of the high-fat diet. (C) 2009 Elsevier Inc. All rights reserved.
C1 [Safwat, Ghada M.; Napolitano, Mariarosaria; Bravo, Elena] Ist Super Sanita, Dept Hematol Oncol & Mol Med, I-00161 Rome, Italy.
   [Pisano, Stefania; Ballanti, Paola] Univ Roma La Sapienza, Dept Expt Med, I-00185 Rome, Italy.
   [D'Amore, Emanuela] Ist Super Sanita, Anim Experimentat Sector, Serv Biotechnol & Anim Welf, I-00161 Rome, Italy.
   [Borioni, Giorgio] Synth Act Srl, Rome, Italy.
   [Safwat, Ghada M.; Kamal, Adel Amin] Beni Suief Univ, Fac Vet Med, Dept Biochem, Beni Suief, Egypt.
   [Botham, Kathleen M.] Univ London Royal Vet Coll, Dept Vet Basic Sci, London, England.
C3 Istituto Superiore di Sanita (ISS); Sapienza University Rome; Istituto
   Superiore di Sanita (ISS); Egyptian Knowledge Bank (EKB); Beni Suef
   University; University of London; University of London Royal Veterinary
   College
RP Bravo, E (corresponding author), Ist Super Sanita, Dept Hematol Oncol & Mol Med, Viale Regina Elena 299, I-00161 Rome, Italy.
EM bravo@iss.it
RI Safwat, Ghada/LOS-9071-2024; Amin, kamal/D-5894-2018; Bravo,
   Elena/AAH-7512-2021; Amin, kamal/A-3416-2015
OI Bravo, Elena/0000-0002-3473-6767; Amin, kamal/0000-0003-2487-8427;
   Botham, Kathleen/0000-0002-0221-979X; Safwat, Ghada/0000-0002-3218-4786;
   Napolitano, Mariarosaria/0000-0002-2041-0897
FU Embassy of the Arab Republic of Egypt in Rome
FX The authors thank the Embassy of the Arab Republic of Egypt in Rome for
   supporting the collaborative study between the ISS and the University of
   Beni Suef University and for the fellowship for G. Safwat. The authors
   thank Prof. Gian Paolo Littarru for his help in Co-Q determinations. The
   authors are grateful to Mr. Antonio Di Virgilio, and Mr. Agostino Eusepi
   for their skilled help with animal work.
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NR 54
TC 36
Z9 42
U1 0
U2 9
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0899-9007
EI 1873-1244
J9 NUTRITION
JI Nutrition
PD NOV-DEC
PY 2009
VL 25
IS 11-12
BP 1157
EP 1168
DI 10.1016/j.nut.2009.02.009
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 508UP
UT WOS:000270962700015
PM 19592219
DA 2025-06-11
ER

PT J
AU Katakam, PVG
   Jordan, JE
   Snipes, JA
   Tulbert, CD
   Miller, AW
   Busija, DW
AF Katakam, Prasad V. G.
   Jordan, James E.
   Snipes, James A.
   Tulbert, Christina D.
   Miller, Allison W.
   Busija, David W.
TI Myocardial preconditioning against ischemia-reperfusion injury is
   abolished in Zucker obese rats with insulin resistance
SO AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE
   PHYSIOLOGY
LA English
DT Article
DE mitochondrial K-ATP; obesity; Type 2 diabetes
ID OXYGEN SPECIES PRODUCTION; CORONARY-HEART-DISEASE; MITOCHONDRIAL K-ATP;
   OXIDATIVE STRESS; METABOLIC SYNDROME; DIABETES-MELLITUS; EXPRESSION;
   CHANNEL; DYSFUNCTION; INFARCTION
AB Myocardial preconditioning against ischemia-reperfusion injury is abolished in Zucker obese rats with insulin resistance. Am J Physiol Regul Integr Comp Physiol 292: R920-R926, 2007. First published September 28, 2006; doi: 10.1152/ajpregu.00520.2006.-Insulin resistance (IR) precedes the onset of Type 2 diabetes, but its impact on preconditioning against myocardial ischemia-reperfusion injury is unexplored. We examined the effects of diazoxide and ischemic preconditioning (IPC; 5-min ischemia and 5-min reperfusion) on ischemia (30 min)-reperfusion (240 min) injury in young IR Zucker obese (ZO) and lean (ZL) rats. ZO hearts developed larger infarcts than ZL hearts (infarct size: 57.3 +/- 3% in ZO vs. 39.2 +/- 3.2% in ZL; P < 0.05) and also failed to respond to cardioprotection by IPC or diazoxide (47.2 +/- 4.3% and 52.5 +/- 5.8%, respectively; P = not significant). In contrast, IPC and diazoxide treatment reduced the infarct size in ZL hearts (12.7 +/- 2% and 16.3 +/- 6.7%, respectively; P < 0.05). The mitochondrial ATP-activated potassium channel (K-ATP) antagonist 5-hydroxydecanoic acid inhibited IPC and diazoxide-induced preconditioning in ZL hearts, whereas it had no effect on ZO hearts. Diazoxide elicited reduced depolarization of isolated mitochondria from ZO hearts compared with ZL (73 +/- 9% in ZL vs. 39 +/- 9% in ZO; P < 0.05). Diazoxide also failed to enhance superoxide generation in isolated mitochondria from ZO compared with ZL hearts. Electron micrographs of ZO hearts revealed a decreased number of mitochondria accompanied by swelling, disorganized cristae, and vacuolation. Immunoblots of mitochondrial protein showed a modest increase in manganese superoxide dismutase in ZO hearts. Thus obesity accompanied by IR is associated with the inability to precondition against ischemic cardiac injury, which is mediated by enhanced mitochondrial oxidative stress and impaired activation of mitochondrial K-ATP.
C1 Wake Forest Univ Hlth Sci, Dept Physiol & Pharmacol, Winston Salem, NC 27157 USA.
   Wake Forest Univ Hlth Sci, Dept Cardiothorac Surg, Winston Salem, NC 27157 USA.
C3 Wake Forest University; Wake Forest University School of Medicine; Wake
   Forest University; Wake Forest University School of Medicine
RP Katakam, PVG (corresponding author), Wake Forest Univ Hlth Sci, Dept Physiol & Pharmacol, Hanes 1050,Med Ctr Blvd, Winston Salem, NC 27157 USA.
EM pkatakam@wfubmc.edu
RI K, P/AAL-6310-2021
OI Katakam, Prasad/0000-0002-4708-9140
FU NHLBI NIH HHS [HL-50587, HL-46558, HL-65380, HL-77731, HL-66074,
   HL-30260] Funding Source: Medline; NIDDK NIH HHS [DK-62372] Funding
   Source: Medline
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NR 47
TC 103
Z9 120
U1 0
U2 3
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0363-6119
EI 1522-1490
J9 AM J PHYSIOL-REG I
JI Am. J. Physiol.-Regul. Integr. Comp. Physiol.
PD FEB
PY 2007
VL 292
IS 2
BP R920
EP R926
DI 10.1152/ajpregu.00520.2006
PG 7
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA 132KU
UT WOS:000243942500035
PM 17008456
DA 2025-06-11
ER

PT J
AU Arcia, CGC
   Encinas, JFA
   Raimundo, JRS
   de Gois, KC
   Alves, BDA
   Perez, MM
   Gascón, TM
   Fonseca, FLA
   da Veiga, GL
AF Costas Arcia, Catherine Giovanna
   Araujo Encinas, Jessica Freitas
   Santos Raimundo, Joyce Regina
   de Gois, Katharyna Cardoso
   Alves, Beatriz da Costa Aguiar
   Perez, Matheus Moreira
   Gascon, Thais Moura
   Fonseca, Fernando Luiz Affonso
   da Veiga, Glaucia Luciano
TI Downregulation of Tnf-α and Cat Expression in a Wistar Rat
   Diabetic Model during Diabetes Onset
SO CURRENT DIABETES REVIEWS
LA English
DT Article
DE Diabetes mellitus; metabolic syndrome; cardiorenal syndrome; natriuretic
   peptides; biomarkers
ID ATRIAL-NATRIURETIC-PEPTIDE; PATHOPHYSIOLOGY; INTERLEUKIN-6; PATHWAYS;
   SYSTEM
AB Introduction Diabetes Mellitus (DM) is a metabolic disorder characterized by persistent hyperglycemia and/or insulin resistance. If left uncontrolled, it can lead to a combination of cardiac and renal alterations known as cardiorenal syndrome. Additionally, oxidative stress and inflammation contribute to tissue damage, thereby reducing the life expectancy of individuals with diabetes. Aim The aim of this study was to identify early molecular markers associated with cardiorenal syndrome, oxidative stress, and inflammation, and to investigate their correlation with the duration of exposure to DM. Methods An experimental DM model was employed using Wistar rats. The rats were divided into four groups: diabetic rats at 7 days (DM7), diabetic rats at 30 days (DM30), control sham at 7 days (CS7), and control sham at 30 days (CS30). Blood and brain tissue from the brainstem region were collected at 7 and 30 days after confirming DM induction. Gene expression analysis of Bnp, Anp, Cat, Gpx, Sod, Tnf-alpha, and Il-6 was performed. Results The analysis revealed lower expression values of Cat in the brainstem tissue of the DM7 group compared to the NDS7 group. Moreover, diabetic animals exhibited statistically lower levels of Tnf-alpha in their peripheral blood compared to the control animals. Conclusion This study concluded that DM alters the oxidative balance in the brainstem after 7 days of DM induction, resulting in lower Cat expression levels. Although some genes did not show statistical differences after 30 days of DM induction, other genes exhibited no expression values, indicating possible gene silencing. The study identified an imbalance in the studied pathways and concluded that the organism undergoes a compensatory state in response to the initial metabolic alterations caused by DM.
C1 [Costas Arcia, Catherine Giovanna; Araujo Encinas, Jessica Freitas; Santos Raimundo, Joyce Regina; de Gois, Katharyna Cardoso; Alves, Beatriz da Costa Aguiar; Perez, Matheus Moreira; Gascon, Thais Moura; Fonseca, Fernando Luiz Affonso; da Veiga, Glaucia Luciano] Ctr Univ Saude ABC FMABC, Lab Anal Clin, Santo Andre, Brazil.
   [Fonseca, Fernando Luiz Affonso] Univ Fed Sao Paulo, Dept Ciencias Farmaceut, Campus Diadema, Diadema, Brazil.
C3 Universidade Federal de Sao Paulo (UNIFESP)
RP da Veiga, GL (corresponding author), Ctr Univ Saude ABC FMABC, Lab Anal Clin, Santo Andre, Brazil.
EM grlveiga@gmail.com
RI Fonseca, Fernando/E-6836-2012; Reis, Beatriz/F-2311-2014; da Veiga,
   Glaucia/L-8546-2016
FX Declared none.
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NR 34
TC 0
Z9 0
U1 1
U2 2
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1573-3998
EI 1875-6417
J9 CURR DIABETES REV
JI Curr. Diabetes Reviews
PY 2025
VL 21
IS 5
DI 10.2174/0115733998264880230919062657
EA JUN 2024
PG 7
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA O2N7T
UT WOS:001258636700001
PM 38910479
DA 2025-06-11
ER

PT J
AU Yasar, NE
   Konukoglu, D
AF Yasar, Nesibe Esra
   Konukoglu, Dildar
TI Plasma Levels of Soluble P-Selectin, Beta-Thromboglobulin and Platelet
   Indices in Patients with Prediabetes: Effects of Acute Hyperglycemic
   Stress
SO TURKISH JOURNAL OF ENDOCRINOLOGY AND METABOLISM
LA English
DT Article
DE Platelet Activation; mean platelet volume; prediabetic state;
   hyperglycemia
ID METABOLIC SYNDROME; DISTRIBUTION WIDTH; DIABETES-MELLITUS; VOLUME;
   ACTIVATION; GLUCOSE; RISK; ATHEROSCLEROSIS; COAGULATION; PROGNOSIS
AB Objective: To examine the effects of acute hyperglycemic stress on platelet activation by analyzing the plasma levels of P-selectin, beta-thromboglobulin, and platelet indices in an oral glucose tolerance test (OGTT). Material and Methods: The OGTT results were used to form four study groups: a control group (n=31) and a prediabetic group (n=103) comprising three subgroups according to the American Diabetes Association criteria for diabetes. Platelet count (PLT), mean platelet volume (MPV), platelet distribution width (PDW), and plateletcrit (PCT) were determined using the impedance method, and P-selectin and beta-thromboglobulin (beta-TG) levels were determined by enzyme-linked immunosorbent assay. P<0.05 was considered significant. Results: No significant difference was observed in the baseline values of PLT, platelet indices, or plasma P-selectin level between the control and prediabetic groups. The baseline plasma beta-TG level was significantly higher in the prediabetic group than in the control group (p<0.001). PLT, PCT and P-selectin levels significantly reduced during OGTT in both control (p<0.05 for each) and prediabetic groups (p<0.001 for each). The reduction in PCT (3.88%) and PLT (3.18%) after glucose loading was greater in the prediabetic group than in the control group (2.04% and 1.44%, respectively). The MPV decreased in the prediabetic group (p<0.05), while no significant decrease was observed in the control group. Conclusion: The platelet indices do not change in the prediabetic stage and the initiation of granule activation is independent of platelet morphology. Acute hyperglycemia appears to affect platelet morphology and function in both healthy and prediabetic subjects, and can be marked in prediabetic individuals.
C1 [Yasar, Nesibe Esra; Konukoglu, Dildar] Istanbul Univ Cerrahpasa, Fac Med Istanbul, Dept Med Biochem, Istanbul, Turkey.
   [Yasar, Nesibe Esra; Konukoglu, Dildar] Minist Hlth, Banaz Publ Hosp, Usak, Turkey.
C3 Istanbul University - Cerrahpasa; Ministry of Health - Turkey
RP Yasar, NE (corresponding author), Minist Hlth, Banaz Publ Hosp, Usak, Turkey.
EM esrayasar2014@hotmail.com
RI Konukoglu, Dildar/D-4951-2019
OI Konukoglu, Dildar/0000-0002-6095-264X
FU Scientific Research Projects Unit of Istanbul University [24475]
FX This study was supported by Scientific Research Projects Unit of
   Istanbul University (project number: 24475). The authors wish to thank
   Ozlem YALCIN and Jermin BENLIOGLU for their technical assistance.
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NR 36
TC 0
Z9 0
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U2 2
PU TURKIYE KLINIKLERI
PI ANKARA
PA NASUH AKAR MAH, CADDESI NO 30, BALGAT, ANKARA, 06520, TURKEY
SN 1301-2193
J9 TURK J ENDOCRINOL ME
JI Turk. J. Endocrinol. Metab.
PD JUN
PY 2021
VL 25
IS 2
BP 174
EP 183
DI 10.25179/tjem.2020-79546
PG 10
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA SU8FS
UT WOS:000663367200007
DA 2025-06-11
ER

PT J
AU Wijayatunga, NN
   Dhurandhar, EJ
AF Wijayatunga, Nadeeja Niranjalie
   Dhurandhar, Emily Jane
TI Normal weight obesity and unaddressed cardiometabolic health risk-a
   narrative review
SO INTERNATIONAL JOURNAL OF OBESITY
LA English
DT Review
ID ADIPOSE-TISSUE INFLAMMATION; BODY-MASS INDEX; NUTRITION EXAMINATION;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; GENE POLYMORPHISM; OXIDATIVE
   STRESS; NATIONAL-HEALTH; UNITED-STATES; FAT
AB Normal weight obesity (NWO) is defined as having a normal body mass index (BMI), but a high body fat mass. There is growing interest in individuals with NWO, which is an underdiagnosed and understudied group, because of their increased risk for cardiometabolic morbidity and mortality. In this review, we summarized the definition, prevalence, etiology, pathophysiology, and cardiovascular outcomes seen in NWO. We have also summarized the available literature on interventions for NWO. There is a wide variation in the body fat percent cutoffs used to diagnose excess body fat. Hence, the prevalence rates of NWO vary between different populations and studies. It is estimated that about 30 million Americans have NWO and the worldwide prevalence ranges from 4.5% to 22%. Genetics, diet, and physical activity are related to NWO. However, etiological factors are not clear. Changes in body composition, inflammation, oxidative stress are present in NWO in comparison to normal weight lean (NWL) who have a normal BMI and normal body fat amount. Furthermore, cardiometabolic changes are observed and some are subclinical. Thus, screening for NWO will enhance the primary prevention of cardiovascular disease. Due to the use of various body fat percent cutoffs and methods to measure body fat, it is challenging to compare between studies. Researchers working in this field should ideally work towards developing standard body fat percent cutoffs for diagnosing NWO. There are many gaps in the literature on NWO unlike for overt obesity and future studies should explore the etiology, molecular mechanisms, and adipose tissue changes of NWO as well as conduct well planned and executed randomized controlled trials testing dietary, physical, and behavioral interventions for NWO in both males and females of different racial and age groups.
C1 [Wijayatunga, Nadeeja Niranjalie] Univ Mississippi, Dept Nutr & Hospitality Management, University, MS 38677 USA.
   [Dhurandhar, Emily Jane] Texas Tech Univ, Dept Kinesiol & Sport Management, Lubbock, TX 79409 USA.
   [Dhurandhar, Emily Jane] Obthera Inc, Lubbock, TX USA.
C3 University of Mississippi; Texas Tech University System; Texas Tech
   University
RP Wijayatunga, NN (corresponding author), Univ Mississippi, Dept Nutr & Hospitality Management, University, MS 38677 USA.
EM nadeejaw@olemiss.edu
RI Wijayatunga, Nadeeja/AAG-6563-2019
OI Wijayatunga, Nadeeja/0000-0002-7725-2420
FU Texas Tech University
FX This work was supported by startup funds from Texas Tech University.
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NR 97
TC 59
Z9 63
U1 1
U2 20
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0307-0565
EI 1476-5497
J9 INT J OBESITY
JI Int. J. Obes.
PD OCT
PY 2021
VL 45
IS 10
BP 2141
EP 2155
DI 10.1038/s41366-021-00858-7
EA MAY 2021
PG 15
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA US8IA
UT WOS:000653149600001
PM 34007010
DA 2025-06-11
ER

PT J
AU Orach, J
   Rider, CF
   Carlsten, C
AF Orach, Juma
   Rider, Christopher F.
   Carlsten, Christopher
TI Concentration-dependent health effects of air pollution in controlled
   human exposures
SO ENVIRONMENT INTERNATIONAL
LA English
DT Review
DE Controlled human exposures; Air pollution; Concentration-response; Acute
   exposures
ID DIESEL-EXHAUST INHALATION; LONG-TERM EXPOSURE; HEART-RATE-VARIABILITY;
   PARTICULATE MATTER; WOOD-SMOKE; ULTRAFINE PARTICLES; OXIDATIVE STRESS;
   SYSTEMIC INFLAMMATION; ENGINE EXHAUST; FINE PARTICLES
AB Background: Air pollution is a leading contributor to premature mortality worldwide and is often represented by particulate matter (PM), a key contributor to its harmful health effects. Concentration-response relationships are useful for quantifying the effects of air pollution in relevant populations and in considering potential effect thresholds. Controlled human exposures can provide data on acute effects and concentration?response re-lationships that complement epidemiological studies. Objectives: We examined PM concentration-responses after controlled human air pollution exposures to examine exposure?response markers, assess effect modifiers, and identify potential effect thresholds. Methods: We reviewed primary research from published controlled human exposure studies where responses were reported at multiple target PM concentrations or summarized per unit change in PM to identify concentration-dependent effects. Results: Of the 191 publications identified through PubMed and supplementary searches, 31 were eligible. Eligible studies collectively represented four pollutant models: concentrated ambient particles, engineered car-bon nanoparticles, diesel exhaust, and woodsmoke. We identified concentration-dependent effects on oxidative stress markers, inflammation, and cardiovascular function that overlapped across different pollutants. Metabolic syndrome and glutathione s-transferase mu 1 genotype were identified as potential effect modifiers. Discussion: Improved understanding of concentration?response relationships is integral to biomonitoring and mitigation of health effects through impact assessment and policy. Although we identified potential concen-tration?response markers, thresholds, and modifiers, our conclusions on these relationships were limited by a dearth of eligible publications, considerable variability in methodology, and inconsistent reporting standards between studies. More research is required to validate these observations. We recommend that future studies harmonize estimate reporting to facilitate the identification of robust response markers across research and applied settings.
C1 [Orach, Juma; Rider, Christopher F.; Carlsten, Christopher] Univ British Columbia, Vancouver Coastal Hlth Res Inst, Dept Med, Air Pollut Exposure Lab,Div Resp Med, Vancouver, BC, Canada.
C3 Vancouver Coastal Health Research Institute; University of British
   Columbia
RP Carlsten, C (corresponding author), Vancouver Gen Hosp Gordon & Leslie, Lung Ctr, Diamond Hlth Care Ctr, 7th Floor,2775 Laurel St, Vancouver, BC V5Z 1M9, Canada.
EM carlsten@mail.ubc.ca
RI Rider, Christopher/H-7073-2019
OI Orach, Juma/0000-0002-9676-7921
FU WorkSafe BC Research Training Award [2019-TG05]; Canada Research Chairs
   program
FX JO was supported by a WorkSafe BC Research Training Award (2019-TG05) .
   CC was supported by the Canada Research Chairs program. The authors
   thank Ms. Agnes Yuen for her help with text and figure editing.
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NR 135
TC 47
Z9 49
U1 1
U2 83
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0160-4120
EI 1873-6750
J9 ENVIRON INT
JI Environ. Int.
PD MAY
PY 2021
VL 150
AR 106424
DI 10.1016/j.envint.2021.106424
EA FEB 2021
PG 12
WC Environmental Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology
GA QT1IH
UT WOS:000626346000004
PM 33596522
OA gold
DA 2025-06-11
ER

PT J
AU Rezig, L
   Ghzaiel, I
   Ksila, M
   Yammine, A
   Nury, T
   Zarrouk, A
   Samadi, M
   Chouaibi, M
   Vejux, A
   Lizard, G
AF Rezig, Leila
   Ghzaiel, Imen
   Ksila, Mohamed
   Yammine, Aline
   Nury, Thomas
   Zarrouk, Amira
   Samadi, Mohammad
   Chouaibi, Moncef
   Vejux, Anne
   Lizard, Gerard
TI Cytoprotective activities of representative nutrients from the
   Mediterranean diet and of Mediterranean oils against
   7-ketocholesterol-and 7?-hydroxycholesterol-induced cytotoxicity:
   Application to age-related diseases and civilization diseases
SO STEROIDS
LA English
DT Review
DE Age -related diseases; Civilization diseases; Mediterranean diet;
   Nutrients; Carotenoids; Fatty acids; Phytosterols; Polyphenols;
   Tocopherols; Mediterranean oils
ID 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1; D-ALPHA-TOCOPHEROL; PLANT
   STEROLS; FATTY-ACIDS; DOCOSAHEXAENOIC ACID; CHRONIC INFLAMMATION;
   ALZHEIMERS-DISEASE; OXIDIZED PRODUCTS; MOLECULAR-BIOLOGY; CALCIUM
   INCREASE
AB 7-ketocholesterol and 7 beta-hydroxycholesterol are two oxysterols mainly formed by the autoxidation of cholesterol. These two molecules are interconvertible via specific enzymes. These two oxysterols are often observed at increased amounts in biological fluids as well as tissues and organs affected during age-related diseases and in diseases of civilization such as cardiovascular, neurodegenerative, and ocular diseases as well as type 2 diabetes and metabolic syndrome. Noteworthy, 7-ketocholesterol and 7 beta-hydroxycholesterol induce oxidative stress and inflammation, which are frequently observed in patients with age-related and civilization diseases. For this reason, the involvement of these two oxysterols in the pathophysiology of these diseases is widely suspected. In addition, the toxicity of these oxysterols can lead to death by oxiapoptophagy characterized by oxidative stress, apoptosis induction and autophagy criteria. To prevent, or even treat, certain age-related or civilization diseases associated with increased levels of 7-ketocholesterol and 7 beta-hydroxycholesterol, the identification of molecules or mixtures of molecules attenuating or inhibiting the toxic effects of these oxysterols allows to consider new treatments. In this context, many nutrients present in significant amounts in the Mediterranean diet, especially tocopherols, fatty acids, and polyphenols, have shown cytoprotective activities as well as several Mediterranean oils (argan and olive oils, milk thistle seed oil, and pistacia lentiscus seed oil). Consequently, a nutraceutical approach, rich in nutrients present in the Mediterranean diet, could thus make it possible to counteract certain age-related and civilization diseases associated with increased levels of 7-ketocholesterol and 7 beta hydroxycholesterol.
C1 [Rezig, Leila] Univ Carthage, Natl Inst Appl Sci & Technol, LR11E526, LIP MB Lab Prot Engn & Bioact Mol, Tunis 1080, Tunisia.
   [Rezig, Leila; Chouaibi, Moncef] Univ Carthage, High Inst Food Ind, 58 Alain Savary St, Tunis 1003, Tunisia.
   [Ghzaiel, Imen; Ksila, Mohamed; Yammine, Aline; Nury, Thomas; Vejux, Anne; Lizard, Gerard] Univ Bourgogne, INSERM, Team BioPeroxIL, Biochem Peroxisome Inflammat & Lipid Metab EA7270, F-21000 Dijon, France.
   [Ghzaiel, Imen; Zarrouk, Amira] Univ Monastir, Fac Med, LR12ES05, Lab NAFS Nutr Funct Food & Vasc Hlth, Monastir 5000, Tunisia.
   [Ghzaiel, Imen] Univ Tunis El Manar, Fac Sci Tunis, Tunis 2092, Tunisia.
   [Ksila, Mohamed] Univ Tunis El Manar, Fac Sci, Dept Biol, Lab Neurophysiol Cellular Physiopathol & Valorisa, Tunis 2092, Tunisia.
   [Yammine, Aline] Inst Europeen Antioxydants IEA, 1B,Rue Victor Lespinats, F-54230 Neuves Maisons, France.
   [Zarrouk, Amira] Univ Sousse, Fac Med, Lab Biochem, Sousse 4000, Tunisia.
   [Samadi, Mohammad] Univ Lorraine, Dept Chem, Metz Technopole, LCPMC A2,ICPM, F-57070 Metz, France.
   [Chouaibi, Moncef] Univ Carthage, Biopreservat & Valorizat Agr Prod UR13 AGR 02, High Inst Food Ind, 58 Alain Savary St, Tunis 1003, Tunisia.
C3 Universite de Carthage; Universite de Carthage; Universite Bourgogne
   Europe; Institut National de la Sante et de la Recherche Medicale
   (Inserm); Universite de Monastir; Universite de Tunis-El-Manar; Faculte
   des Sciences de Tunis (FST); Universite de Tunis-El-Manar; Faculte des
   Sciences de Tunis (FST); Universite de Sousse; Universite de Lorraine;
   Universite de Carthage
RP Rezig, L (corresponding author), High Inst Food Ind, 58 Alain Savary St, Tunis 1003, Tunisia.; Lizard, G (corresponding author), Lab BioPeroxIL, EA7270, Fac Sci Gabriel, 6 Bd Gabriel, F-21000 Dijon, France.
EM l_rezig@yahoo.it; gerard.lizard@u-bourgogne.fr
RI NURY, THOMAS/IZQ-3626-2023; Amira, Zarrouk/AFN-1200-2022; REZIG,
   Leila/GRY-6373-2022; Vejux, Anne/C-1509-2019; Lizard, Gerard/B-2439-2012
OI Zarrouk, Amira/0000-0002-9190-5328; KSILA, Mohamed/0000-0002-1710-9753;
   chouaibi, moncef/0000-0002-9548-6773; NURY, THOMAS/0000-0002-2190-9630
FU Nutrition Mediterraneenne et Sante (NMS), 'Institut Europeen des
   Antioxydants' (Neuves-Maisons, France); ABASIM (Association
   Bourguignonne pour les Applications des Sciences de l'Information en
   Medecine; Dijon, France); ABASIM; PHC Utique (2021-2022, Campus France)
   [CMCU22G089, 47608V]; Institut Europeen des Antioxydants; Universite de
   Bourgogne (Dijon, France); Universite de Monastir (Monastir, Tunisia);
   Universite Tunis El Manar (Tunis, Tunisia)
FX Imen Ghzaiel received financial support from Nutrition Mediterraneenne
   et Sante (NMS), 'Institut Europeen des Antioxydants' (Neuves-Maisons,
   France) and was awarded the NMS prize (RomaneeConti) in 2021. Imen
   Ghzaiel also received financial support from ABASIM (Association
   Bourguignonne pour les Applications des Sciences de l'Information en
   Medecine; Dijon, France). Mohamed Ksila received financial support from
   ABASIM and from PHC Utique (2021-2022; code CMCU22G089;/code Campus
   France 47608V). Gerard Lizard and Amira Zarrouk are members of the
   International Natural Product Sciences Taskforce (INPST:
   https://inpst.net/accessed on May 20, 2022). Aline Yammine received
   financial support from the 'Institut Europeen des Antioxydants'. This
   work was funded by : Universite de Bourgogne (Dijon, France), Universite
   de Monastir (Monastir, Tunisia), and Universite Tunis El Manar (Tunis,
   Tunisia).
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NR 130
TC 24
Z9 24
U1 0
U2 8
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0039-128X
EI 1878-5867
J9 STEROIDS
JI Steroids
PD NOV
PY 2022
VL 187
AR 109093
DI 10.1016/j.steroids.2022.109093
EA AUG 2022
PG 10
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 4P2MC
UT WOS:000855228600001
PM 36029811
DA 2025-06-11
ER

PT J
AU Lai, HH
   Helmuth, ME
   Smith, AR
   Wiseman, JB
   Gillespie, BW
   Kirkali, Z
   Amundsen, C
   Weinfurt, K
   Flynn, K
   Fraser, MO
   Harshbarger, T
   Jelovsek, E
   Lentz, A
   Peterson, D
   Siddiqui, N
   Weidner, A
   Dombeck, C
   Gilliam, R
   Hayes, A
   Kreder, K
   Bradley, CS
   Erickson, BA
   Lutgendorf, SK
   Magnotta, V
   O'Donnell, MA
   Sung, V
   Alzubaidi, A
   Cella, D
   Helfand, B
   Griffith, JW
   Kenton, K
   Lewicky-Gaupp, C
   Parrish, T
   Chen, JY
   Mueller, M
   Buono, S
   Corona, M
   Menendez, B
   Siurek, A
   Tavathia, M
   Venezuela, V
   Muftic, A
   Talaty, P
   Nero, J
   Helfand
   Talaty
   Nero
   Clemens, JQ
   Berger, M
   DeLancey, J
   Fenner, D
   Harris, R
   Harte, S
   Cameron, AP
   Wei, J
   Barroso, M
   Dmek, L
   Mowatt, G
   Tumbarello, J
   Yang, C
   Gore, JL
   Liu, A
   Vicars, B
   Andriole, GL
   Shimony, J
   Mueller, S
   Wilson, H
   Ksiazek, D
   Klim, A
   Kusek, J
   Bavendam, T
   Star, R
   Norton, J
   Merion, R
   Andreev, V
   Gillespie, B
   Liu, G
   Smith, A
   Fava, M
   Hill-Callahan, P
   Buck, T
   Helmuth, M
   Wiseman, J
   Lock, J
AF Lai, H. Henry
   Helmuth, Margaret E.
   Smith, Abigail R.
   Wiseman, Jonathan B.
   Gillespie, Brenda W.
   Kirkali, Ziya
   Amundsen, Cindy
   Weinfurt, Kevin
   Flynn, Kathryn
   Fraser, Matthew O.
   Harshbarger, Todd
   Jelovsek, Eric
   Lentz, Aaron
   Peterson, Drew
   Siddiqui, Nazema
   Weidner, Alison
   Dombeck, Carrie
   Gilliam, Robin
   Hayes, Akira
   Kreder, Karl
   Bradley, Catherine S.
   Erickson, Bradley A.
   Lutgendorf, Susan K.
   Magnotta, Vince
   O'Donnell, Michael A.
   Sung, Vivian
   Alzubaidi, Ahmad
   Cella, David
   Helfand, Brian
   Griffith, James W.
   Kenton, Kimberly
   Lewicky-Gaupp, Christina
   Parrish, Todd
   Chen, Jennie Yufen
   Mueller, Margaret
   Buono, Sarah
   Corona, Maria
   Menendez, Beatriz
   Siurek, Alexis
   Tavathia, Meera
   Venezuela, Veronica
   Muftic, Azra
   Talaty, Pooja
   Nero, Jasmine
   Helfand
   Talaty
   Nero
   Clemens, J. Quentin
   Berger, Mitch
   DeLancey, John
   Fenner, Dee
   Harris, Rick
   Harte, Steve
   Cameron, Anne P.
   Wei, John
   Barroso, Morgen
   Dmek, Linda
   Mowatt, Greg
   Tumbarello, Julie
   Yang, Claire
   Gore, John L.
   Liu, Alice
   Vicars, Brenda
   Andriole, Gerald L.
   Shimony, Joshua
   Mueller, Susan
   Wilson, Heather
   Ksiazek, Deborah
   Klim, Aleksandra
   Kusek, John
   Bavendam, Tamara
   Star, Robert
   Norton, Jenna
   Merion, Robert
   Andreev, Victor
   Gillespie, Brenda
   Liu, Gang
   Smith, Abigail
   Fava, Melissa
   Hill-Callahan, Peg
   Buck, Timothy
   Helmuth, Margaret
   Wiseman, Jon
   Lock, Julieanne
CA Symptoms Lower Urinary Tract Dysfu
TI Relationship Between Central Obesity, General Obesity, Overactive
   Bladder Syndrome and Urinary Incontinence Among Male and Female Patients
   Seeking Care for Their Lower Urinary Tract Symptoms
SO UROLOGY
LA English
DT Article
ID LIFE-STYLE FACTORS; METABOLIC SYNDROME; RISK-FACTORS;
   STRESS-INCONTINENCE; WOMEN; ASSOCIATION; PREVALENCE; HEALTH; DIET
AB OBJECTIVE To describe the relationship between metabolic factors and lower urinary tract symptoms, overactive bladder syndrome (OAB) and urinary incontinence (UI).
   METHODS Adult male and female patients who presented to a clinician from the symptoms of lower urinary tract dysfunction research network were recruited. Urinary symptoms (presence of OAB, any UI, stress UI (SUI), urgency UI (UUI), urgency, frequency, and nocturia) were assessed with the lower urinary tract symptoms tool. Metabolic factors assessed included central obesity (waist circumference, using the Adult Treatment Panel III, the International Diabetes Federation thresholds, and waist circumference as a continuous variable), general obesity (body mass index as dichotomous or continuous variables), diabetes mellitus, hypertension, and dyslipidemia. Multivariable logistic regression was used to test for associations.
   RESULTS 920 participants were studied. In multivariable analyses, central obesity (per 10 cm larger waist) was associated with higher odds of UI in both sexes (odds ratio [OR] = 1.16, P = .008), SUI in females (OR= 1.27, P = .008), UUI in both sexes (OR = 1.24, P = .001), OAB in females (OR = 1.248, P = .003), as well as frequency and nocturia. General obesity (5-unit increase in body mass index) was associated with UI, UUI, urgency and frequency in both sexes, and with SUI and OAB in females. We did not find associations between central or general obesity and OAB in males. Dyslipidemia was associated with nocturia >= 2.
   CONCLUSION In patients, central and general obesity were key metabolic factors associated with UI in both males and females, and with OAB in females but not in males. The association between dyslipidemia and nocturia >= 2 needs further research. (C) 2018 Published by Elsevier Inc.
C1 Washington Univ, Sch Med, Div Urol Surg, St Louis, MO USA.
   Arbor Res Collaborat Hlth, Ann Arbor, MI USA.
   Univ Michigan, Dept Biostat, Ann Arbor, MI 48109 USA.
   NIDDK, Bethesda, MD 20892 USA.
C3 Washington University (WUSTL); Arbor Research Collaborative for Health;
   University of Michigan System; University of Michigan; National
   Institutes of Health (NIH) - USA; NIH National Institute of Diabetes &
   Digestive & Kidney Diseases (NIDDK)
RP Lai, HH (corresponding author), Washington Univ, Div Urol Surg, Dept Surg, Sch Med, 4960 Childrens Pl,Campus Box 8242, St Louis, MO 63110 USA.
EM laih@wudosis.wustl.edu
RI Helmuth, Margaret/AAQ-3411-2020; Cella, D/AFH-8180-2022; Harshbarger,
   Todd/AAR-1317-2020; Griffith, James/O-2551-2016; O'Donnell,
   Martin/ABE-7459-2020; Kirkali, Ziya/AAC-1629-2021
OI Cameron, Anne/0000-0001-8414-3065; Kirkali, Ziya/0000-0002-2918-4347;
   Helmuth, Margaret/0000-0003-3311-3223; Smith,
   Abigail/0000-0001-5496-4460
FU National Institute of Diabetes & Digestive & Kidney Diseases [DK097780,
   DK097772, DK097779, DK099932, DK100011, DK100017, DK097776, DK099879];
   National Institute of Diabetes and Digestive and Kidney Diseases
   [U01DK099932] Funding Source: NIH RePORTER
FX This study is supported by the National Institute of Diabetes &
   Digestive & Kidney Diseases through cooperative agreements (grants
   DK097780, DK097772, DK097779, DK099932, DK100011, DK100017, DK097776,
   DK099879).
CR Abrams P, 2002, NEUROUROL URODYNAM, V21, P167, DOI 10.1002/nau.10052
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NR 30
TC 54
Z9 55
U1 0
U2 5
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0090-4295
EI 1527-9995
J9 UROLOGY
JI Urology
PD JAN
PY 2019
VL 123
BP 34
EP 43
DI 10.1016/j.urology.2018.09.012
PG 10
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA HF9BF
UT WOS:000454535600015
PM 30393054
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Ganz, T
   Wainstein, J
   Gilad, S
   Limor, R
   Boaz, M
   Stern, N
AF Ganz, Tali
   Wainstein, Julio
   Gilad, Suzan
   Limor, Rona
   Boaz, Mona
   Stern, Naftali
TI Serum asymmetric dimethylarginine and arginine levels predict
   microvascular and macrovascular complications in type 2 diabetes
   mellitus
SO DIABETES-METABOLISM RESEARCH AND REVIEWS
LA English
DT Article
DE diabetes complications; metabolic syndrome; obesity
ID NITRIC-OXIDE SYNTHASE; ENDOTHELIAL DYSFUNCTION; CARDIOVASCULAR-DISEASE;
   SKELETAL-MUSCLE; PLASMA-CONCENTRATIONS; VASCULAR DYSFUNCTION;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; BLOOD-FLOW; ADMA
AB Background Increased oxidative stress in diabetes increases nitric oxide (NO) oxidation and low L-arginine (Arg) could further reduce NO and impair vascular function, thereby accelerating, in the long run, vascular complications. We therefore measured Arg and asymmetric dimethylarginine (ADMA) levels in patients with type 2 diabetes mellitus (T2DM) and healthy controls. Additionally, we observed the diabetic individuals over time to see if Arg and asymmetric dimethylarginine predicted T2DM complications.
   Methods We examined baseline serum Arg and ADMA levels in a cohort of 105 participants with type 2 diabetes and compared them with an age-and weight-matched nondiabetic group of 137 individuals who served as a reference population. Additionally, we assessed whether Arg and/or ADMA predicted macrovascular and microvascular complications over 6 years of follow-up.
   Results Serum Arg was lower in individuals with T2DM than in controls (64 +/- 28 vs 75 +/- 31 mu mol/L; P =.009) and inversely related to hemoglobin A1c (r = -0.2; P =.002). Over follow-up, we observed that participants with T2DM in the lowest quartile of Arg had increased risk for the subsequent evolution of nephropathy, peripheral neuropathy, and composite microvascular complications (odds ratio [ OR] = 5.5; 95% confidence interval [CI] -1.9 to 16; P =.002). The highest ADMA quartile was associated with increased risk for both microvascular (OR = 4.5; 95% CI -1.4 to 14.1; P =.009) and 6.5-year incident macrovascular complications (OR = 8.3; 95% CI 1.9-35.5; P =.004).
   Conclusion L-Arginine levels are lower in individuals with T2DM than in matched controls. Both low Arg and high ADMA, independent of each other and adjusted for classical risk factors, predict the incidence of microvascular complications.
C1 [Ganz, Tali; Wainstein, Julio] Med Ctr Holon, Diabet Unit, Holon, Israel.
   [Ganz, Tali; Wainstein, Julio; Stern, Naftali] Tel Aviv Univ, Sackler Fac Med, Tel Aviv, Israel.
   [Gilad, Suzan; Limor, Rona; Stern, Naftali] Tel Aviv Sourasky Med Ctr, Inst Endocrinol Metab & Hypertens, Tel Aviv, Israel.
   [Boaz, Mona] Ariel Univ, Dept Nutr Sci, Ariel, Israel.
   [Boaz, Mona] Wolfson Med Ctr, Epidemil & Res Unit, Holon, Israel.
C3 Tel Aviv University; Sackler Faculty of Medicine; Tel Aviv University;
   Sackler Faculty of Medicine; Tel Aviv Sourasky Medical Center; Ariel
   University; Tel Aviv University
RP Boaz, M (corresponding author), Ariel Univ, Dept Nutr Sci, Ariel, Israel.
EM mboaz8@yahoo.com
RI Boaz, Mona/O-6940-2014
OI Boaz, Mona/0000-0002-3920-7549
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NR 66
TC 34
Z9 34
U1 0
U2 9
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1520-7552
EI 1520-7560
J9 DIABETES-METAB RES
JI Diabetes-Metab. Res. Rev.
PD FEB
PY 2017
VL 33
IS 2
AR e2836
DI 10.1002/dmrr.2836
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA EP5DQ
UT WOS:000397399600008
PM 27393712
DA 2025-06-11
ER

PT J
AU Abraham, NG
   Sodhi, K
   Silvis, AM
   Vanella, L
   Favero, G
   Rezzani, R
   Lee, C
   Zeldin, DC
   Schwartzman, ML
AF Abraham, Nader G.
   Sodhi, Komal
   Silvis, Anne M.
   Vanella, Luca
   Favero, Gaia
   Rezzani, Rita
   Lee, Craig
   Zeldin, Darryl C.
   Schwartzman, Michal L.
TI CYP2J2 Targeting to Endothelial Cells Attenuates Adiposity and Vascular
   Dysfunction in Mice Fed a High-Fat Diet by Reprogramming Adipocyte
   Phenotype
SO HYPERTENSION
LA English
DT Article
DE 11,12-EET; AMP-activated protein kinases; aP2 protein, human; eNOS
   protein, rat; heme oxygenase-1; mesoderm-specific transcript protein
ID IMPROVES INSULIN SENSITIVITY; EPOXYGENASE-DERIVED EICOSANOIDS; INCREASES
   ADIPONECTIN LEVELS; INDUCED RENAL INJURY; HEME OXYGENASE-1; OBESE MICE;
   11,12-EPOXYEICOSATRIENOIC ACID; EPOXYEICOSATRIENOIC ACIDS; METABOLIC
   SYNDROME; VISCERAL OBESITY
AB Obesity is a global epidemic and a common risk factor for endothelial dysfunction and the subsequent development of diabetes mellitus and vascular diseases such as hypertension. Epoxyeicosatrienoic acids (EETs) are cytochrome P450 (CYP)-derived metabolites of arachidonic acid that contribute to vascular protection by stimulating vasodilation and inhibiting inflammation. Heme oxygenase-1 is a stress response protein that plays an important cytoprotective role against oxidative insult in diabetes mellitus and cardiovascular disease. We recently demonstrated interplay between EETs and heme oxygenase-1 in the attenuation of adipogenesis. We examined whether adipocyte dysfunction in mice fed a high-fat diet could be prevented by endothelial-specific targeting of the human CYP epoxygenase, CYP2J2. Tie2-CYP2J2 transgenic mice, fed a high-fat diet, had a reduction in body weight gain, blood glucose, insulin levels, and inflammatory markers. Tie2-CYP2J2 gene targeting restored HF-mediated decreases in vascular heme oxygenase-1, Cyp2C44, soluble epoxide hydrolase, phosphorylated endothelial nitric oxide synthase, phosphorylated protein kinase B, and phosphorylated adenosine monophosphate protein kinase protein expression, thus improving vascular function. These changes translated into decreased inflammation and oxidative stress within adipose tissue and decreased peroxisome proliferator-activated receptor-gamma, CCAAT/enhancer binding protein alpha, mesoderm-specific transcript, and adipocyte 2 expression and increased uncoupling protein 1 and uncoupling protein 2 expression, reflecting the effect of vascular EET overproduction on adipogenesis. The current study documents a direct link between endothelial-specific EET production and adipogenesis, further implicating the EET-heme oxygenase-1 crosstalk as an important cytoprotective mechanism in the amelioration of vascular and adipocyte dysfunction resulting from diet-induced obesity.
C1 [Abraham, Nader G.; Schwartzman, Michal L.] New York Med Coll, Dept Med, Valhalla, NY 10595 USA.
   [Abraham, Nader G.; Schwartzman, Michal L.] New York Med Coll, Dept Pharmacol, Valhalla, NY 10595 USA.
   [Sodhi, Komal; Silvis, Anne M.] Marshall Univ, Joan C Edwards Sch Med, Dept Med, Huntington, WV USA.
   [Sodhi, Komal; Silvis, Anne M.] Marshall Univ, Joan C Edwards Sch Med, Dept Obstet & Gynecol, Huntington, WV USA.
   [Vanella, Luca] Univ Catania, Dept Drug Sci, Biochem Sect, Catania, Italy.
   [Vanella, Luca] Univ Catania, Dept Drug Sci, Med Chem Sect, Catania, Italy.
   [Favero, Gaia; Rezzani, Rita] Univ Brescia, Dept Clin & Expt Sci, Div Anat & Physiopathol, Brescia, Italy.
   [Lee, Craig; Zeldin, Darryl C.] NIEHS, Div Intramural Res, NIH, Res Triangle Pk, NC 27709 USA.
C3 New York Medical College; New York Medical College; Marshall University;
   Marshall University; University of Catania; University of Catania;
   University of Brescia; National Institutes of Health (NIH) - USA; NIH
   National Institute of Environmental Health Sciences (NIEHS)
RP Abraham, NG (corresponding author), New York Med Coll, Dept Med, Valhalla, NY 10595 USA.
EM nader_abraham@nymc.edu
RI Zeldin, Darryl/Y-7091-2018; Vanella, Luca/J-7354-2016
OI Zeldin, Darryl/0000-0002-2087-7307; Favero, Gaia/0000-0001-6895-7106;
   Vanella, Luca/0000-0002-6314-6029; Lee, Craig/0000-0003-3595-5301
FU National Institutes of Health (NIH) [HL55601, HL34300]; Intramural
   Research Program of the NIH, National Institute of Environmental Health
   Sciences [Z01 ES025034]
FX This work was supported by National Institutes of Health (NIH) grants
   HL55601 (N.G. Abraham) and HL34300 (M. L. Schwartzman). This work was
   also supported, in part, by the Intramural Research Program of the NIH,
   National Institute of Environmental Health Sciences (Z01 ES025034 to
   D.C. Zeldin).
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NR 58
TC 56
Z9 62
U1 0
U2 11
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0194-911X
EI 1524-4563
J9 HYPERTENSION
JI Hypertension
PD DEC
PY 2014
VL 64
IS 6
BP 1352
EP U413
DI 10.1161/HYPERTENSIONAHA.114.03884
PG 17
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA AT7PL
UT WOS:000345129900036
PM 25245389
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Adkins, Y
   Schie, IW
   Fedor, D
   Reddy, A
   Nguyen, S
   Zhou, P
   Kelley, DS
   Wu, J
AF Adkins, Yuriko
   Schie, Iwan W.
   Fedor, Dawn
   Reddy, Aurosis
   Nguyen, Samantha
   Zhou, Ping
   Kelley, Darshan S.
   Wu, Jian
TI A novel mouse model of nonalcoholic steatohepatitis with significant
   insulin resistance
SO LABORATORY INVESTIGATION
LA English
DT Article
DE animal model; insulin resistance; lipid droplets; nonalcoholic
   steatohepatitis; raman micro-spectroscopy
ID CONJUGATED LINOLEIC-ACID; FATTY LIVER-DISEASE; DOCOSAHEXAENOIC ACID;
   HEPATIC STEATOSIS; PREVENTS TRANS-10; IN-VIVO; MICE; METABOLISM;
   DIACYLGLYCEROL; EXPRESSION
AB Currently available models insufficiently reflect the pathogenic alternation of nonalcoholic steatohepatitis\NASH), such as insulin resistance. The present study aimed to characterize a novel NASH model caused by feeding the diet containing conjugated linoleic acid (CLA). In this study, mice were fed a control diet or the diet containing 0.5% CLA for 8 weeks. The insulin tolerance test (ITT) and homeostasis model assessment of insulin resistance (HOMA-IR) were used to determine the extent of insulin resistance. Liver lipotoxicity and inflammation were assessed by endoplasmic reticulum (ER) stress, autolipophagy, recruitment of Kupffer cells and hepatic stellate cell (HSC) activation. We found that liver weight was markedly increased, and histopathological examination showed marked macrosteatosis with focal hepatocellular death through apoptosis, and mild pericellular fibrosis with Kupffer cell recruitment and HSC activation, as well as light chain III beta-positive cells and enhanced ER stress in mice fed the CLA-containing diet. Enhanced synthesis and reduced beta-oxidation of fatty acids resulted in their accumulation and lipotoxicity in hepatocytes. A biophotonic technology revealed lipid droplet accumulation in the liver from mice fed the CLA-containing diet, and Raman spectroscopic analysis indicated that these lipid droplets predominantly contained saturated fatty acids. Elevated fasting insulin levels, abnormal ITT and HOMA-IR confirmed the marked insulin resistance in these mice. Decreased phosphorylation of the insulin-signaling molecule Akt was partially responsible for the significant insulin resistance. In conclusion, Mice fed the diet containing CLA-developed steatohepatitis with marked insulin resistance, which is similar to the characteristics observed in NASH patients. The further characterization of this model would be particularly useful for revealing the critical role of insulin resistance in NASH development in conditions such as metabolic syndrome, diabetes and obesity.
C1 [Adkins, Yuriko; Reddy, Aurosis; Kelley, Darshan S.] ARS, Western Human Nutr Res Ctr, USDA, Livermore, CA 95616 USA.
   [Adkins, Yuriko; Fedor, Dawn; Kelley, Darshan S.] Univ Calif Davis, Dept Nutr, Davis, CA 95616 USA.
   [Schie, Iwan W.] Univ Calif Davis, Davis Med Ctr, Ctr Biophoton Sci & Technol, Sacramento, CA 95817 USA.
   [Nguyen, Samantha; Wu, Jian] Univ Calif Davis, Davis Med Ctr, Div Gastroenterol & Hepatol, Dept Internal Med, Sacramento, CA 95817 USA.
   [Zhou, Ping; Wu, Jian] Univ Calif Davis, Davis Med Ctr, Stem Cell Program, Sacramento, CA 95817 USA.
   [Wu, Jian] Fudan Univ, Shanghai Med Coll, Key Lab Mol Virol, Shanghai 200433, Peoples R China.
C3 United States Department of Agriculture (USDA); University of California
   System; University of California Davis; University of California System;
   University of California Davis; University of California System;
   University of California Davis; University of California System;
   University of California Davis; Fudan University
RP Kelley, DS (corresponding author), ARS, Western Human Nutr Res Ctr, USDA, Davis 430 West Hlth Sci Dr, Livermore, CA 95616 USA.
EM Darshan.Kelley@ars.usda.gov; jdwu@ucdavis.edu
RI Wu, Jian/AAU-5221-2020
OI Adkins, Yuriko/0000-0002-5705-5964; Schie, Iwan/0000-0003-0336-3168
FU United States Department of Agriculture, Agricultural Research Service
   [5306-51530-017-00D]; NIH [DK069939]
FX We thank Dr Rajen Ramsamooj in the Department of Pathology and
   Laboratory Medicine, UC Davis Medical Center for technical assistance in
   the process of tissue sections for H&E and Trichrome staining. The study
   was supported by the United States Department of Agriculture,
   Agricultural Research Service, through Parent project
   (5306-51530-017-00D) to the Immunity and Disease Prevention Unit at
   Western Human Nutrition Research Center; and by the NIH Grant to JW
   (DK069939).
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NR 37
TC 29
Z9 34
U1 0
U2 33
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 0023-6837
EI 1530-0307
J9 LAB INVEST
JI Lab. Invest.
PD DEC
PY 2013
VL 93
IS 12
BP 1313
EP 1322
DI 10.1038/labinvest.2013.123
PG 10
WC Medicine, Research & Experimental; Pathology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pathology
GA 263GO
UT WOS:000327795600006
PM 24145238
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU van Duijnhoven, FJB
   Bueno-De-Mesquita, HB
   Calligaro, M
   Jenab, M
   Pischon, T
   Jansen, EHJM
   Frohlich, J
   Ayyobi, A
   Overvad, K
   Toft-Petersen, AP
   Tjonneland, A
   Hansen, L
   Boutron-Ruault, MC
   Clavel-Chapelon, F
   Cottet, V
   Palli, D
   Tagliabue, G
   Panico, S
   Tumino, R
   Vineis, P
   Kaaks, R
   Teucher, B
   Boeing, H
   Drogan, D
   Trichopoulou, A
   Lagiou, P
   Dilis, V
   Peeters, PHM
   Siersema, PD
   Rodríguez, L
   González, CA
   Molina-Montes, E
   Dorronsoro, M
   Tormo, MJ
   Barricarte, A
   Palmqvist, R
   Hallmans, G
   Khaw, KT
   Tsilidis, KK
   Crowe, FL
   Chajes, V
   Fedirko, V
   Rinaldi, S
   Norat, T
   Riboli, E
AF van Duijnhoven, Franzel J. B.
   Bueno-De-Mesquita, H. Bas
   Calligaro, Miriam
   Jenab, Mazda
   Pischon, Tobias
   Jansen, Eugene H. J. M.
   Frohlich, Jiri
   Ayyobi, Amir
   Overvad, Kim
   Toft-Petersen, Anne Pernille
   Tjonneland, Anne
   Hansen, Louise
   Boutron-Ruault, Marie-Christine
   Clavel-Chapelon, Francoise
   Cottet, Vanessa
   Palli, Domenico
   Tagliabue, Giovanna
   Panico, Salvatore
   Tumino, Rosario
   Vineis, Paolo
   Kaaks, Rudolf
   Teucher, Birgit
   Boeing, Heiner
   Drogan, Dagmar
   Trichopoulou, Antonia
   Lagiou, Pagona
   Dilis, Vardis
   Peeters, Petra H. M.
   Siersema, Peter D.
   Rodriguez, Laudina
   Gonzalez, Carlos A.
   Molina-Montes, Esther
   Dorronsoro, Miren
   Tormo, Maria-Jose
   Barricarte, Aurelio
   Palmqvist, Richard
   Hallmans, Goran
   Khaw, Kay-Tee
   Tsilidis, Kostas K.
   Crowe, Francesca L.
   Chajes, Veronique
   Fedirko, Veronika
   Rinaldi, Sabina
   Norat, Teresa
   Riboli, Elio
TI Blood lipid and lipoprotein concentrations and colorectal cancer risk in
   the European Prospective Investigation into Cancer and Nutrition
SO GUT
LA English
DT Article
ID C-REACTIVE PROTEIN; METABOLIC SYNDROME; OXIDATIVE STRESS; SERUM
   TRIGLYCERIDE; RECTAL-CANCER; PARTICLE-SIZE; CHOLESTEROL; COLON;
   ASSOCIATION; INSULIN
AB Objective To examine the association between serum concentrations of total cholesterol, high density lipoprotein cholesterol (HDL), low density lipoprotein cholesterol, triglycerides, apolipoprotein A-I (apoA), apolipoprotein B and the incidence of colorectal cancer (CRC).
   Design Nested case-control study.
   Setting The study was conducted within the European Prospective Investigation into Cancer and Nutrition (EPIC), a cohort of more than 520 000 participants from 10 western European countries.
   Participants 1238 cases of incident CRC, which developed after enrolment into the cohort, were matched with 1238 controls for age, sex, centre, follow-up time, time of blood collection and fasting status.
   Main outcome measures Serum concentrations were quantitatively determined by colorimetric and turbidimetric methods. Dietary and lifestyle data were obtained from questionnaires. Conditional logistic regression models were used to estimate incidence rate ratios (RRs) and 95% CIs which were adjusted for height, weight, smoking habits, physical activity, education, consumption of fruit, vegetables, meat, fish, alcohol, fibre and energy.
   Results After adjustments, the concentrations of HDL and apoA were inversely associated with the risk of colon cancer (RR for 1 SD increase of 16.6 mg/dl in HDL and 32.0 mg/dl in apoA of 0.78 (95% CI 0.68 to 0.89) and 0.82 (95% CI 0.72 to 0.94), respectively). No association was observed with the risk of rectal cancer. Additional adjustment for biomarkers of systemic inflammation, insulin resistance and oxidative stress or exclusion of the first 2 years of follow-up did not influence the association between HDL and risk of colon cancer.
   Conclusions These findings show that high concentrations of serum HDL are associated with a decreased risk of colon cancer. The mechanism behind this association needs further elucidation.
C1 [van Duijnhoven, Franzel J. B.; Bueno-De-Mesquita, H. Bas; Calligaro, Miriam; Jansen, Eugene H. J. M.] Natl Inst Publ Hlth & Environm RIVM, Bilthoven, Netherlands.
   [van Duijnhoven, Franzel J. B.] Univ Med Ctr, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands.
   [Bueno-De-Mesquita, H. Bas; Siersema, Peter D.] Univ Med Ctr, Dept Gastroenterol & Hepatol, Utrecht, Netherlands.
   [Jenab, Mazda; Chajes, Veronique; Fedirko, Veronika; Rinaldi, Sabina] Int Agcy Res Canc IARC WHO, Lyon, France.
   [Pischon, Tobias; Boeing, Heiner; Drogan, Dagmar] German Inst Human Nutr Potsdam Rehbrucke, Dept Epidemiol, Nuthetal, Germany.
   [Frohlich, Jiri; Ayyobi, Amir] Univ British Columbia, St Pauls Hosp, Vancouver, BC V5Z 1M9, Canada.
   [Overvad, Kim] Aarhus Univ, Sch Publ Hlth, Dept Epidemiol, Aarhus, Denmark.
   [Overvad, Kim; Toft-Petersen, Anne Pernille] Aarhus Univ Hosp, Aalborg Hosp, Dept Cardiol, Aalborg, Denmark.
   [Tjonneland, Anne; Hansen, Louise] Danish Canc Soc, Inst Canc Epidemiol, Copenhagen, Denmark.
   [Boutron-Ruault, Marie-Christine; Clavel-Chapelon, Francoise; Cottet, Vanessa] Paris S Univ, Inst Gustave Roussy, Ctr Res Epidemiol & Populat Hlth, INSERM,UMRS 1018,Team 9, F-94805 Villejuif, France.
   [Palli, Domenico] ISPO Canc Res & Prevent Inst, Mol & Nutr Epidemiol Unit, Florence, Italy.
   [Tagliabue, Giovanna] Fdn IRCCS Inst Nazl Tumori, Environm Epidemiol Unit, Milan, Italy.
   [Tagliabue, Giovanna] Fdn IRCCS Inst Nazl Tumori, Canc Registry, Milan, Italy.
   [Panico, Salvatore] Univ Naples Federico II, Dept Clin & Expt Med, Naples, Italy.
   [Tumino, Rosario] Civile MP Arezzo Hosp, Dept Oncol, Histopathol Unit, Ragusa, Italy.
   [Tumino, Rosario] Civile MP Arezzo Hosp, Canc Registry, Ragusa, Italy.
   [Vineis, Paolo] HuGeF Fdn Torino, Turin, Italy.
   [Vineis, Paolo] Univ London Imperial Coll Sci Technol & Med, Sch Publ Hlth, MRC HPA Ctr Environm & Hlth, London, England.
   [Kaaks, Rudolf; Teucher, Birgit] German Canc Res Ctr, Div Canc Epidemiol, D-6900 Heidelberg, Germany.
   [Trichopoulou, Antonia; Lagiou, Pagona] Univ Athens, Sch Med, Dept Hyg Epidemiol & Med Stat, WHO Collaborating Ctr Food & Nutr Policies, GR-11527 Athens, Greece.
   [Trichopoulou, Antonia; Dilis, Vardis] Hellen Hlth Fdn, Athens, Greece.
   [Peeters, Petra H. M.; Norat, Teresa; Riboli, Elio] Univ London Imperial Coll Sci Technol & Med, Div Epidemiol Publ Hlth & Primary Care, London, England.
   [Rodriguez, Laudina] Hlth & Hlth Care Serv Council, Publ Hlth & Participat Directorate, Asturias, Spain.
   [Gonzalez, Carlos A.] Catalan Inst Oncol, Unit Nutr Environm & Canc, Barcelona, Spain.
   [Molina-Montes, Esther] Andalusia Sch Publ Hlth, Granada, Spain.
   [Dorronsoro, Miren] Dept Publ Hlth Guipuzkoa, San Sebastian, Spain.
   [Tormo, Maria-Jose] Murcia Reg Hlth Council, Dept Epidemiol, Murcia, Spain.
   [Barricarte, Aurelio] Publ Hlth Inst Navarra, Pamplona, Spain.
   [Palmqvist, Richard] Umea Univ, Dept Med Biosci, Umea, Sweden.
   [Hallmans, Goran] Umea Univ, Dept Publ Hlth & Clin Med, Umea, Sweden.
   [Khaw, Kay-Tee] Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge CB2 1TN, England.
   [Tsilidis, Kostas K.; Crowe, Francesca L.] Univ Oxford, Nuffield Dept Clin Med, Canc Epidemiol Unit, Oxford, England.
C3 Netherlands National Institute for Public Health & the Environment;
   Utrecht University; Utrecht University Medical Center; Utrecht
   University; Utrecht University Medical Center; World Health
   Organization; International Agency for Research on Cancer (IARC);
   Leibniz Association; Deutsches Institut fur Ernahrungsforschung
   Potsdam-Rehbrucke (DIfE); St. Paul's Hospital; University of British
   Columbia; Aarhus University; Aarhus University; Aalborg University;
   Aalborg University Hospital; Danish Cancer Society; UNICANCER; Gustave
   Roussy; Institut National de la Sante et de la Recherche Medicale
   (Inserm); ISPRO Istituto per lo studio, la prevenzione e la rete
   oncologica; Fondazione IRCCS Istituto Nazionale Tumori Milan; Fondazione
   IRCCS Istituto Nazionale Tumori Milan; University of Naples Federico II;
   Civile M.P. Arezzo Hospital; Civile M.P. Arezzo Hospital; Imperial
   College London; Helmholtz Association; German Cancer Research Center
   (DKFZ); National & Kapodistrian University of Athens; Athens Medical
   School; World Health Organization; Imperial College London; Institut
   Catala d'Oncologia; Escuela Andaluza de Salud Publica; Murcia Regional
   Health Council; Public Health Institute of Navarra; Umea University;
   Umea University; University of Cambridge; University of Oxford
RP van Duijnhoven, FJB (corresponding author), Natl Inst Publ Hlth & Environm, Ctr Nutr & Hlth, POB 1, NL-3720 BA Bilthoven, Netherlands.
EM franzel.van.duijnhoven@rivm.nl
RI Jenab, Mehdi/L-2515-2019; van Duijnhoven, Fränzel/GWC-0059-2022; Cottet,
   Vanessa/ABE-3236-2020; Panico, Salvatore/K-6506-2016; TRICHOPOULOU,
   ANTONIA/ABF-8727-2021; Riboli, Elio/A-4357-2009; González,
   Carlos/O-4651-2014; Boutron-Ruault, Marie-Christine/H-3936-2014;
   Sánchez, María/HOC-7747-2023; Tjonneland, Anne/AGU-0320-2022; Siersema,
   Peter/V-1636-2019; Tagliabue, Giovanna/D-4194-2017; Molina-Montes,
   Esther/AFS-7568-2022; Teucher, Birgit/J-6380-2015; Clavel-Chapelon,
   Francoise/G-6733-2014; Pischon, Tobias/HGE-8577-2022; Khaw,
   Kay-Tee/AAZ-3209-2021
OI Riboli, Elio/0000-0001-6795-6080; Pischon, Tobias/0000-0003-1568-767X
FU European Commission: Public Health and Consumer Protection Directorate;
   Ligue contre le Cancer; Societe 3M; Mutuelle Generale de l'Education
   Nationale; Institut National de la Sante et de la Recherche Medicale
   (INSERM) (France); German Cancer Aid; German Cancer Research Center;
   Federal Ministry of Education and Research (Germany); Danish Cancer
   Society (Denmark); Spanish Ministry of Health; Associazione Italiana per
   la Ricerca sul Cancro Funding Source: Custom
FX This work was supported by the European Commission: Public Health and
   Consumer Protection Directorate 1993-2004; Research Directorate-General
   2005-.; Ligue contre le Cancer, Societe 3M, Mutuelle Generale de
   l'Education Nationale, Institut National de la Sante et de la Recherche
   Medicale (INSERM) (France); German Cancer Aid, German Cancer Research
   Center, Federal Ministry of Education and Research (Germany); Danish
   Cancer Society (Denmark); Health Research Fund (FIS) of the Spanish
   Ministry of Health, The participating regional governments and
   institutions (Spain); Cancer Research UK, Medical Research Council (UK);
   Hellenic Ministry of Health, the Stavros Niarchos Foundation and the
   Hellenic Health Foundation (Greece); Italian Association for Research on
   Cancer, National Research Council (Italy); Dutch Ministry of Public
   Health, Welfare and Sports (VWS), Netherlands Cancer Registry (NKR), LK
   Research Funds, Dutch Prevention Funds, Dutch ZON (Zorg Onderzoek
   Nederland), World Cancer Research Fund (WCRF), Statistics Netherlands
   (the Netherlands); Swedish Cancer Society, Swedish Scientific Council,
   Regional government of Vasterbotten (Sweden); Norwegian Cancer Society
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NR 43
TC 155
Z9 158
U1 0
U2 25
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 0017-5749
EI 1468-3288
J9 GUT
JI Gut
PD AUG
PY 2011
VL 60
IS 8
BP 1094
EP 1102
DI 10.1136/gut.2010.225011
PG 9
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 786OQ
UT WOS:000292318200015
DA 2025-06-11
ER

PT J
AU Jamroz-Wisniewska, A
   Wójcicka, G
   Lowicka, E
   Ksiazek, M
   Beltowski, J
AF Jamroz-Wisniewska, Anna
   Wojcicka, Grazyna
   Lowicka, Ewelina
   Ksiazek, Marta
   Beltowski, Jerzy
TI Transactivation of epidermal growth factor receptor in vascular and
   renal systems in rats with experimental hyperleptinemia:: Role in
   leptin-induced hypertension
SO BIOCHEMICAL PHARMACOLOGY
LA English
DT Article
DE leptin; arterial hypertension; epidermal growth factor receptor;
   extracellular signal-regulated kinases; c-Src tyrosine kinase;
   Na+,K+-ATPase
ID SMOOTH-MUSCLE-CELLS; ACTIVATED-PROTEIN-KINASE; SIGNAL-REGULATED KINASE;
   ANGIOTENSIN-II; OXIDATIVE STRESS; NA+,K+-ATPASE ACTIVITY; RESISTANCE
   ARTERIES; SODIUM-TRANSPORT; EXPRESSION; MITOGEN
AB We examined the role of epidermal growth factor (EGF) receptor in the pathogenesis of leptin-induced hypertension in the rat. Leptin, administered in increasing doses (0.1-0.5 mg/kg/day) for 10 days, increased phosphorylation levels of non-receptor tyrosine kinase, c-Src, EGF receptor and extracellular signal-regulated kinases (ERK) in aorta and kidney, which was accompanied by the increase in plasma concentration and urinary excretion of isoprostanes and H2O2. Blood pressure and renal Na+,K+-ATPase activity were higher, whereas urinary sodium excretion was lower in animals receiving leptin. The effects of leptin on renal Na+,K+-ATPase, natriuresis and blood pressure were abolished by NADPH oxidase inhibitor, apocynin, Src kinase inhibitor, PP2, EGF receptor inhibitor, AG1478, protein farnesyltransferase inhibitor, manumycin A, and ERK inhibitor, PD98059. In contrast, inhibitors of insulin-like growth factor-1 and platelet-derived growth factor receptors, AG1024 and AG1295, respectively, only slightly reduced ERK phosphorylation and had no effect on blood pressure in rats receiving leptin. These data indicate that: (1) experimental hyperleptinemia. is associated with oxidative stress and c-Src-dependent transactivation of the EGF receptor, which stimulates ERK in vascular wall and the kidney, (2) overactivity of EGF receptor-ERK pathway contributes to leptin-induced hypertension by stimulating renal Na+,K+-ATPase and reducing sodium excretion, (3) inhibitors of c-Src, EGF receptor and ERK may be considered as a novel therapy for hypertension associated with hyperleptinemia, e.g. in patients with obesity and metabolic syndrome. (c) 2008 Elsevier Inc. All rights reserved.
C1 [Jamroz-Wisniewska, Anna; Wojcicka, Grazyna; Lowicka, Ewelina; Beltowski, Jerzy] Med Univ, Dept Pathophysiol, PL-20090 Lublin, Poland.
   [Ksiazek, Marta] 2nd Res Hosp, Dept Anesthesiol & Intens Care, Rzeszow, Poland.
C3 Medical University of Lublin
RP Beltowski, J (corresponding author), Med Univ, Dept Pathophysiol, Ul Jaczewskiego 8, PL-20090 Lublin, Poland.
EM jerzy.beltowski@am.lublin.pl
RI Beltowski, Jerzy/AAH-4692-2020
OI Wojcicka, Grazyna/0000-0002-1822-5027; Beltowski,
   Jerzy/0000-0001-7903-8121
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NR 63
TC 26
Z9 26
U1 0
U2 1
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0006-2952
EI 1873-2968
J9 BIOCHEM PHARMACOL
JI Biochem. Pharmacol.
PD APR 15
PY 2008
VL 75
IS 8
BP 1623
EP 1638
DI 10.1016/j.bcp.2008.01.003
PG 16
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 295KM
UT WOS:000255473400007
PM 18282556
DA 2025-06-11
ER

PT J
AU Dai, H
   Fu, Q
   Chen, H
   Zhang, M
   Sun, M
   Gu, Y
   Zhou, NT
   Yang, T
AF Dai, Hao
   Fu, Qi
   Chen, Heng
   Zhang, Mei
   Sun, Min
   Gu, Yong
   Zhou, Ningtian
   Yang, Tao
TI A novel numerical model of combination levels of C-peptide and insulin
   in coronary artery disease risk prediction
SO MATHEMATICAL BIOSCIENCES AND ENGINEERING
LA English
DT Article
DE coronary artery disease; C-peptide-to-insulin ratio index; exercise
   electrocardiography test; insulin resistance; stress echocardiography
ID HEART-DISEASE; CARDIOVASCULAR-DISEASE; HEPATIC EXTRACTION; METABOLIC
   SYNDROME; WEIGHT-LOSS; RESISTANCE; OBESITY; GLUCOSE; CLEARANCE;
   SENSITIVITY
AB Objective: Insulin resistance is a major risk factor for coronary artery disease (CAD). The C-peptide-to-insulin ratio (C/I) is associated with hepatic insulin clearance and insulin resistance. The current study was designed to establish a novel C/I index (CPIRI) model and provide early risk assessment of CAD. Methods: A total of 865 adults diagnosed with new-onset diabetes mellitus (DM) within one year and 54 healthy controls (HC) were recruited to develop a CPIRI model. The CPIRI model was established with fasting C/I as the independent variable and homeostasis model assessment of insulin resistance (HOMA-IR) as the dependent variable. Associations between the CPIRI model and the severity of CAD events were also assessed in 45 hyperglycemic patients with CAD documented via coronary arteriography (CAG) and whom underwent stress echocardiography (SE) and exercise electrocardiography test (EET). Results: Fasting C-peptide/insulin and HOMA-IR were hyperbolically correlated in DM patients and HC, and log(C/I) and log(HOMA-IR) were linearly and negatively correlated. The respective correlational coefficients were -0.83 (p < 0.001) and -0.76 (p < 0.001). The equations CPIRI(DM) = 670/(C/I)2.24 + 0.25 and CPIRI(HC) = 670/(C/I)2.24 - 1 (F = 1904.39, p < 0.001) were obtained. Patients with insulin resistance exhibited severe coronary artery impairment and myocardial ischemia. In CAD patients there was no significant correlation between insulin resistance and the number of vessels involved. Conclusions: CPIRI can be used to effectively evaluate insulin resistance, and the combination of CPIRI and non-invasive cardiovascular examination is of great clinical value in the assessment of CAD.
C1 [Dai, Hao; Fu, Qi; Chen, Heng; Zhang, Mei; Sun, Min; Gu, Yong; Yang, Tao] Nanjing Med Univ, Dept Endocrinol & Metab, Affiliated Hosp 1, 300 Guangzhou Rd, Nanjing 210029, Peoples R China.
   [Zhou, Ningtian] Nanjing Med Univ, Dept Cardiol, Affiliated Hosp 1, 300 Guangzhou Rd, Nanjing 210029, Peoples R China.
C3 Nanjing Medical University; Nanjing Medical University
RP Yang, T (corresponding author), Nanjing Med Univ, Dept Endocrinol & Metab, Affiliated Hosp 1, 300 Guangzhou Rd, Nanjing 210029, Peoples R China.; Zhou, NT (corresponding author), Nanjing Med Univ, Dept Cardiol, Affiliated Hosp 1, 300 Guangzhou Rd, Nanjing 210029, Peoples R China.
EM zhouningtian@jsph.org.cn; yangt@njmu.edu.cn
FU National Natural Science Foundation of China [81530026, 81830023];
   Jiangsu Provincial Special Program of Medical Science [BE2017753]
FX This work was supported by grants from the National Natural Science
   Foundation of China (81530026, 81830023) , and Jiangsu Provincial
   Special Program of Medical Science (BE2017753) .
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NR 40
TC 0
Z9 0
U1 0
U2 3
PU AMER INST MATHEMATICAL SCIENCES-AIMS
PI SPRINGFIELD
PA PO BOX 2604, SPRINGFIELD, MO 65801-2604 USA
SN 1547-1063
EI 1551-0018
J9 MATH BIOSCI ENG
JI Math. Biosci. Eng.
PY 2021
VL 18
IS 3
BP 2675
EP 2687
DI 10.3934/mbe.2021136
PG 13
WC Mathematical & Computational Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Mathematical & Computational Biology
GA TD7LO
UT WOS:000669503800014
PM 33892566
OA gold
DA 2025-06-11
ER

PT J
AU Bukhbinder, AS
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AF Bukhbinder, Avram S.
   Wang, Austin C.
   Qureshi, Salah U.
   Arora, Garima
   Jawaid, Ali
   Kalkonde, Yogeshwar, V
   Petersen, Nancy J.
   Yu, Hong-Jen
   Kimbrell, Timothy
   Pyne, Jeffrey M.
   Magruder, Kathy M.
   Hudson, Teresa J.
   Bush, Ruth L.
   Kunik, Mark E.
   Schulz, Paul E.
TI Increased Vascular Pathology in Older Veterans With a Purple Heart
   Commendation or Chronic Post-Traumatic Stress Disorder
SO JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY
LA English
DT Article
DE PTSD; purple heart; vascular risk factors; vascular disease
ID SERUM-LIPID CONCENTRATIONS; METABOLIC SYNDROME; DIABETES-MELLITUS;
   CARDIOVASCULAR-DISEASE; PHYSICAL ILLNESS; VIETNAM VETERANS;
   RISK-FACTORS; CORONARY; HEALTH; PTSD
AB The goal of this retrospective cohort study was to determine whether stressors related to military service, determined by a diagnosis of chronic post-traumatic stress disorder (cPTSD) or receiving a Purple Heart (PH), are associated with an increased risk of vascular risk factors and disease, which are of great concern for veterans, who constitute a significant portion of the aging US population. The Veterans Integrated Service Network (VISN) 16 administrative database was searched for individuals 65 years or older between October 1, 1997 to September 30, 1999 who either received a PH but did not have cPTSD (PH+/cPTSD-; n = 1499), had cPTSD without a PH (PH-/cPTSD+; n = 3593), had neither (PH-/cPTSD-; n = 5010), or had both (PH+/cPTSD+; n = 153). In comparison to the control group (PH-/cPTSD-), the PH+/cPTSD- group had increased odds ratios for incidence and prevalence of diabetes mellitus, hypertension, and hyperlipidemia. The PH-/cPTSD+ group had increased odds ratios for prevalence of diabetes mellitus and for the incidence and prevalence of hyperlipidemia. The PH-/cPTSD+ and PH+/cPTSD- groups were associated with ischemic heart disease and cerebrovascular disease, but not independently of the other risk factors. The PH+/cPTSD+ group was associated only with an increase in the incidence and prevalence of hyperlipidemia, though this group's much smaller sample size may limit the reliability of this finding. We conclude that certain physical and psychological stressors related to military service are associated with a greater incidence of several vascular risk factors in veterans aged 65 years or older, which in turn are associated with greater rates of ischemic heart disease and cerebrovascular disease.
C1 [Bukhbinder, Avram S.; Wang, Austin C.; Arora, Garima; Schulz, Paul E.] Univ Texas Hlth Sci Ctr Houston, McGovern Med Sch, Dept Neurol, UTHlth, Houston, TX 77030 USA.
   [Bukhbinder, Avram S.; Wang, Austin C.; Arora, Garima; Schulz, Paul E.] UTHlth, McGovern Med Sch, Mischer Neurosci Inst, Houston, TX 77054 USA.
   [Bukhbinder, Avram S.; Wang, Austin C.; Arora, Garima; Schulz, Paul E.] Mem Hermann Texas Med Ctr, Houston, TX USA.
   [Qureshi, Salah U.; Petersen, Nancy J.; Yu, Hong-Jen; Kunik, Mark E.] Michael E DeBakey VA Med Ctr, Houston Vet Affairs Hlth Serv Res & Dev Serv Ctr, Houston, TX USA.
   [Qureshi, Salah U.; Kalkonde, Yogeshwar, V; Petersen, Nancy J.; Bush, Ruth L.; Kunik, Mark E.] Baylor Coll Med, Houston, TX 77030 USA.
   [Qureshi, Salah U.; Kimbrell, Timothy; Pyne, Jeffrey M.; Hudson, Teresa J.; Kunik, Mark E.] Vet Affairs South Cent Mental Illness Res, Educ & Clin Ctr, Little Rock, AR USA.
   [Jawaid, Ali] Univ Zurich, Brain Res Inst, Lab Neuroepigenet, Zurich, Switzerland.
   [Kimbrell, Timothy; Pyne, Jeffrey M.; Hudson, Teresa J.] Cent Arkansas Vet Healthcare Syst, Ctr Mental Hlth & Outcomes Res, Little Rock, AR USA.
   [Kimbrell, Timothy; Pyne, Jeffrey M.; Hudson, Teresa J.] Univ Arkansas Med Sci, Coll Med, Dept Psychiat, Little Rock, AR 72205 USA.
   [Magruder, Kathy M.] Med Univ South Carolina, Dept Psychiat & Behav Sci, Charleston, SC 29425 USA.
C3 University of Texas System; University of Texas Health Science Center
   Houston; University of Texas System; University of Texas Health Science
   Center Houston; Baylor College of Medicine; Baylor College Medical
   Hospital; Baylor College of Medicine; University of Zurich; US
   Department of Veterans Affairs; Veterans Health Administration (VHA);
   Central Arkansas Veterans Healthcare System; University of Arkansas
   System; University of Arkansas Medical Sciences; Medical University of
   South Carolina
RP Schulz, PE (corresponding author), UTHlth, McGovern Med Sch, Neurocognit Disorders Ctr, Dept Neurol, 1941 East Rd,Suite 4358, Houston, TX 77054 USA.
EM paul.e.schulz@uth.tmc.edu
RI Kajungu, Dan/AAY-8527-2020; Hudson, Teresa/AEK-2092-2022; Jawaid,
   Ali/KBQ-6269-2024; Pyne, Jeffrey/AAA-9280-2019; Bukhbinder,
   Avram/AAM-5685-2020
OI Kalkonde, Yogeshwar/0000-0003-3543-3618; Jawaid,
   Ali/0000-0002-5126-6744; Bukhbinder, Avram/0000-0002-7190-7676
FU VA Center for Innovations in Quality, Effectiveness and Safety [CIN
   13-413]
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: This study
   was partly funded by the VA Center for Innovations in Quality,
   Effectiveness and Safety (#CIN 13-413). The views expressed reflect
   those of the authors and not necessarily those of the Department of
   Veterans Affairs, Baylor College of Medicine, or UTHealth.
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NR 75
TC 2
Z9 2
U1 0
U2 4
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0891-9887
EI 1552-5708
J9 J GERIATR PSYCH NEUR
JI J. Geriatr. Psychiatry Neurol.
PD JUL
PY 2020
VL 33
IS 4
BP 195
EP 206
AR 0891988719868308
DI 10.1177/0891988719868308
EA AUG 2019
PG 12
WC Geriatrics & Gerontology; Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Neurosciences & Neurology; Psychiatry
GA LX3FJ
UT WOS:000483327600001
PM 31426715
DA 2025-06-11
ER

PT J
AU Maffei, P
   Dassie, F
   Wennberg, A
   Parolin, M
   Vettor, R
AF Maffei, Pietro
   Dassie, Francesca
   Wennberg, Alexandra
   Parolin, Matteo
   Vettor, Roberto
TI The Endothelium in Acromegaly
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Review
DE IGF-1; endothelial cells; atherosclerosis; microcirculation; aneurysms;
   IMT; FMD; stiffness
ID GROWTH-FACTOR-I; INTIMA-MEDIA THICKNESS; SECRETING PITUITARY-ADENOMA;
   CARDIOVASCULAR RISK-FACTORS; SMALL-ARTERY STRUCTURE; OXIDATIVE STRESS;
   PROGENITOR CELLS; IGF-I; MYOCARDIAL-INFARCTION; RECEPTOR ANTAGONIST
AB Growth hormone (GH) and insulin like growth factor-1 (IGF-1) excess induce well-known deleterious effects on the cardiovascular system, especially after long-term exposition. Acromegaly, a condition of chronic GH and IGF-1 hypersecretion, is frequently associated to cardiovascular complications, although recent studies have shown a reduction in the prevalence of these comorbidities in well-controlled patients and a mortality risk similar to normal aging population. Many factors could contribute to the increased cardiovascular risk of acromegaly patients. Among these factors, the endothelium plays a key role in the pathogenesis of atherosclerotic plaques and could be considered an early marker of atherosclerosis and cardiovascular dysfunction. In this review we examined the relationship between GH/IGF-1 excess and the endothelium, from basic studies to clinical evidence. Many studies involving various arterial districts (microvascular arteries of retina, kidney and brain, and major vessels as carotid and aorta) showed that GH/IGF-1 excess promotes endothelial dysfunction via several different mechanisms. Increased endothelial proliferation, dysfunction of endothelial progenitor cells, increased oxidative stress, and compromised oxidative defenses are the main factors that are associated with endothelial dysfunction. In the general population, these alterations are associated with the development of atherosclerosis with an increased incidence of coronary artery disease and cerebrovascular complications. However, in acromegaly this is still a debated issue, despite the presence of many pro-atherogenic factors and comorbidities, such as hypertension, diabetes, sleep apnoea, and metabolic syndrome. Preclinical markers of atherosclerosis as arterial intima media thickness, pulse wave velocity and flow mediated dilation seem to be impaired in acromegaly and partly mediated by the endothelium dysfunction. In conclusion, the pathophysiology of endothelial dysfunction in the condition of GH and IGF-1 excess remains a crucial area of investigation to fully dissect the association of acromegaly with cardiovascular disease complications.
C1 [Maffei, Pietro; Dassie, Francesca; Parolin, Matteo; Vettor, Roberto] Padua Univ Hosp, Dept Med DIMED, Clin Med 3, Padua, Italy.
   [Wennberg, Alexandra] Padua Univ Hosp, Clin Neurol, Dept Neurosci DNS, Padua, Italy.
C3 University of Padua; Azienda Ospedaliera - Universita di Padova;
   University of Padua; Azienda Ospedaliera - Universita di Padova
RP Maffei, P (corresponding author), Padua Univ Hosp, Dept Med DIMED, Clin Med 3, Padua, Italy.
EM pietro.maffei@aopd.veneto.it
RI VETTOR, ROBERTO/K-7121-2016; Wennberg, Alexandra/O-9563-2016;
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NR 166
TC 33
Z9 32
U1 0
U2 4
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD JUL 24
PY 2019
VL 10
AR 437
DI 10.3389/fendo.2019.00437
PG 15
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA IL1HR
UT WOS:000477050800001
PM 31396153
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Polus, A
   Bociaga-Jasik, M
   Czech, U
   Goralska, J
   Cialowicz, U
   Chojnacka, M
   Polus, M
   Jurowski, K
   Dembinska-Kiec, A
AF Polus, A.
   Bociaga-Jasik, M.
   Czech, U.
   Goralska, J.
   Cialowicz, U.
   Chojnacka, M.
   Polus, M.
   Jurowski, K.
   Dembinska-Kiec, A.
TI THE HUMAN IMMUNODEFICIENCY VIRUS (HIV 1) PROTEASE INHIBITOR SANQUINAVIR
   ACTIVATES AUTOPHAGY AND REMOVES LIPIDS DEPOSITED IN LIPID DROPLETS
SO JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
LA English
DT Article
DE adipogenesis; lipidomics; microarray; autophagy; miRNA; saquinavir
ID ENDOPLASMIC-RETICULUM STRESS; HUMAN PREADIPOCYTES; ANTIRETROVIRAL
   TREATMENT; METABOLIC SYNDROME; INFECTED PATIENTS; ADIPOSE-TISSUE;
   CELL-SURVIVAL; LIPODYSTROPHY; DIFFERENTIATION; SAQUINAVIR
AB Reduction in mortality and increased average life span of the human immunodeficiency virus (HIV)-infected patients treated with antiretroviral therapy (ART) are associated with the risk of unwanted effects, such as insulin resistance and dyslipidemia with cardiovascular complications. Antiretroviral therapy may also be associated with lipodystrophy characterized as peripheral lipoatrophy with central fat accumulation. Understanding the molecular mechanisms of lipodystrophy caused by ART is important for therapeutic strategy and the prediction of side-effects. Influence of protease inhibitor saquinavir (SQV) on preadipocyte differentiation was analyzed in in vitro human Chub-S7 cell line model. For measurement of the effects of SQV the drug was added to differentiated or non-differentiated cells. The influence of SQV on changes in the profile of gene expression was verified by microarray and changes in lipid species content were analyzed using GC-MS/MS. Results were confirmed by real-time PCR and analysis of autophagy. Addition of SQV to differentiated Chub-S7 cells lead to removal of lipids deposited in lipid droplets, down-regulation of expression of transcription factors and markers of adipocyte differentiation. Antiviral activity of SQV based on its non-selective inhibition of proteases resulted in proteasome inhibition, induction of endoplasmic reticulum stress and induction of macroautophagy. This activity was accompanied by an increase in PI, PEPL, PC lipid species especially with MUFA and PUFA. Additionally up-regulation of miR-100-3p, miR-222-5p, miR-483-5p were found, which correlated with obesity, insulin resistance, increasing insulin secretion and activation of lipolysis. Our results indicated that SQV, by inhibition of proteasome protein degradation, activated the unfolded protein response resulting in autophagic breakdown of lipids deposited in adipose tissue causing lipodystrophy.
C1 [Polus, A.; Czech, U.; Goralska, J.; Cialowicz, U.; Chojnacka, M.; Dembinska-Kiec, A.] Jagiellonian Univ, Med Coll, Dept Clin Biochem, 15A Kopernika St, PL-31501 Krakow, Poland.
   [Bociaga-Jasik, M.] Jagiellonian Univ, Med Coll, Dept Gastroenterol Hepatol & Infect Dis, Krakow, Poland.
   [Polus, M.] Cracow Univ Technol, Fac Environm Engn, Inst Water Supply & Environm Protect, Krakow, Poland.
   [Jurowski, K.] Jagiellonian Univ, Dept Analyt Chem, Fac Chem, Krakow, Poland.
C3 Jagiellonian University; Collegium Medicum Jagiellonian University;
   Jagiellonian University; Collegium Medicum Jagiellonian University;
   Cracow University of Technology; Jagiellonian University
RP Polus, A (corresponding author), Jagiellonian Univ, Med Coll, Dept Clin Biochem, 15A Kopernika St, PL-31501 Krakow, Poland.
EM apolus@cm-uj.krakow.pl
RI Polus, Michal/KOC-8174-2024; Goralska, Joanna/MFI-0965-2025
OI Goralska, Joanna/0000-0002-9557-8440; Polus, Anna/0000-0001-8142-0012
FU State Committee for Scientific Research [N N402 421638, K/ZDS/003774]
FX Study supported by the grant from The State Committee for Scientific
   Research no. N N402 421638 and K/ZDS/003774.
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NR 64
TC 10
Z9 11
U1 0
U2 5
PU POLISH PHYSIOLOGICAL SOC
PI GRZEGORZECKA
PA JAGIELLONIAN UNIV SCHOOL MED, INST PHYSIOLOGY, 31-531 KRAKOW, 16
   GRZEGORZECKA, POLAND
SN 0867-5910
J9 J PHYSIOL PHARMACOL
JI J. Physiol. Pharmacol.
PD APR
PY 2017
VL 68
IS 2
BP 283
EP 293
PG 11
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA FA6HE
UT WOS:000405543100014
PM 28614778
DA 2025-06-11
ER

PT J
AU Jokura, H
   Watanabe, I
   Umeda, M
   Hase, T
   Shimotoyodome, A
AF Jokura, Hiroko
   Watanabe, Isamu
   Umeda, Mika
   Hase, Tadashi
   Shimotoyodome, Akira
TI Coffee polyphenol consumption improves postprandial hyperglycemia
   associated with impaired vascular endothelial function in healthy male
   adults
SO NUTRITION RESEARCH
LA English
DT Article
DE Blood glucose; Coffee polyphenol; Flow-mediated dilatation; GLP-1;
   Insulin
ID GLUCAGON-LIKE PEPTIDE-1; LEFT-VENTRICULAR PERFORMANCE; MYOCARDIAL
   GLUCOSE-UPTAKE; METABOLIC SYNDROME; FAT UTILIZATION; CONSCIOUS DOGS;
   CAFFEINE; GLP-1; RISK; HUMANS
AB Epidemiological studies indicate that habitual coffee consumption lowers the risk of diabetes and cardiovascular diseases. Postprandial hyperglycemia is a direct and independent risk factor for cardiovascular diseases. We previously demonstrated that coffee polyphenol ingestion increased secretion of Glucagon-like peptide 1 (GLP-1), which has been shown to exhibit antidiabetic and cardiovascular effects. We hypothesized coffee polyphenol consumption may improve postprandial hyperglycemia and vascular endothelial function by increasing GLP-1 release and/or reducing oxidative stress. To examine this hypothesis, we conducted a randomized, acute, crossover, intervention study in healthy male adults, measuring blood parameters and flow-mediated dilation (FMD) after ingestion of a meal with or without coffee polyphenol extract (CPE). Nineteen subjects consumed a test meal with either a placebo- or CPE-containing beverage. Blood biomarkers and FMD were measured at fasting and up to 180 minutes postprandially. The CPE beverage led to a significantly lower peak postprandial increase in blood glucose and diacron-reactive oxygen metabolite, and significantly higher postprandial FMD than the placebo beverage. Postprandial blood GLP-1 increase tended to be higher after ingestion of the CPE beverage, compared with placebo. Subclass analysis revealed that the CPE beverage significantly improved postprandial blood GLP-1 response and reduced blood glucose increase in the subjects with a lower insulinogenic index. Correlation analysis showed postprandial FMD was negatively associated with blood glucose increase after ingestion of the CPE beverage. In conclusion, these results suggest that coffee polyphenol consumption improves postprandial hyperglycemia and vascular endothelial function, which is associated with increased GLP-1 secretion and decreased oxidative stress in healthy humans. (C) 2015 Elsevier Inc. All rights reserved.
C1 [Jokura, Hiroko; Watanabe, Isamu; Umeda, Mika; Hase, Tadashi; Shimotoyodome, Akira] Kao Corp, Biol Sci Labs, Ichikai, Tochigi 3213497, Japan.
C3 KAO Corporation
RP Shimotoyodome, A (corresponding author), Kao Corp, Biol Sci Labs, 2606 Akabane, Ichikai, Tochigi 3213497, Japan.
EM shimotoyodome.akira@kao.co.jp
RI Watanabe, Isamu/LIC-8063-2024
OI HASE, TADASHI/0009-0003-3657-5332; shimotoyodome,
   akira/0000-0001-7567-8316
FU Kao Corporation
FX We thank Takuya Watanabe and Kiyoshi Kataoka for preparing the test
   beverages. Our deep gratitude is expressed to Kentaro Okamoto, Dokkyo
   Medical University, for supervising this clinical study. All of the
   authors are employees of Kao Corporation. The present study was
   supported financially by Kao Corporation.
CR [Anonymous], DIABETES CARE
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NR 38
TC 57
Z9 60
U1 0
U2 22
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0271-5317
EI 1879-0739
J9 NUTR RES
JI Nutr. Res.
PD OCT
PY 2015
VL 35
IS 10
BP 873
EP 881
DI 10.1016/j.nutres.2015.07.005
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA CS8BS
UT WOS:000362311300004
PM 26337017
DA 2025-06-11
ER

PT J
AU Teimouri, M
   Hosseini, H
   Shabani, M
   Koushki, M
   Noorbakhsh, F
   Meshkani, R
AF Teimouri, Maryam
   Hosseini, Hossein
   Shabani, Maryam
   Koushki, Mehdi
   Noorbakhsh, Farshid
   Meshkani, Reza
TI Inhibiting miR-27a and miR-142-5p attenuate nonalcoholic fatty liver
   disease by regulating Nrf2 signaling pathway
SO IUBMB LIFE
LA English
DT Article
DE lipogenesis; miR-27a; miR-142-5p; NAFLD; Nrf2; oxidative stress
ID DIET-INDUCED OBESITY; TRANSCRIPTION FACTOR NRF2; GENE-EXPRESSION
   PROFILES; OXIDATIVE STRESS; METABOLIC SYNDROME; INSULIN-RESISTANCE;
   STEATOHEPATITIS; PROGRESSION; ACTIVATION; DELETION
AB The gene Nrf2 (nuclear factor-erythroid 2-related factor 2) is the most important regulator of the cellular antioxidant system and its dysregulation has a role in the etiology of nonalcoholic fatty liver disease (NAFLD). The aim of this study was to investigate the association between Nrf2 targeted miRNAs (miR-27a, miR-142-5p, miR-153, and miR-128) with lipid accumulation in vitro and in vivo models of NAFLD. We used two in vivo and in vitro models of NAFLD. The expression of the genes and miRNAs was assessed by real-time PCR and the protein level was evaluated using western blot. To investigate the potential role of miRNAs in NAFLD, the inhibitors or mimics of the miR-27a and miR-142-5p were transfected into HepG2 cells. The mRNA and protein levels of Nrf2 were significantly decreased in the liver of high fat diet-fed mice as well as in HepG2 cells treated with high glucose (HG). Reduced expression of Nrf2 was associated with increased expression levels of miR-27a and miR-142-5p in both models of NAFLD. HG-induced triglyceride accumulation was attenuated by inhibition of miR-27a or miR-142-5p in HepG2 cells. Overexpression of miR-27a or miR-142-5p suppressed the expression of Nrf2 and its downstream antioxidant genes and increased production of reactive oxygen species, whereas inhibition of miR-27a or miR-142-5p reversed these effects. In conclusion, the data of this study may suggest that miR-27a and miR-142-5p are increased in NAFLD, where they suppress Nrf2 expression and contribute to the accumulation of lipids in the hepatocytes.
C1 [Teimouri, Maryam; Hosseini, Hossein; Shabani, Maryam; Koushki, Mehdi; Meshkani, Reza] Univ Tehran Med Sci, Dept Clin Biochem, Fac Med, Tehran, Iran.
   [Noorbakhsh, Farshid] Univ Tehran Med Sci, Dept Immunol, Fac Med, Tehran, Iran.
C3 Tehran University of Medical Sciences; Tehran University of Medical
   Sciences
RP Meshkani, R (corresponding author), Univ Tehran Med Sci, Dept Clin Biochem, Fac Med, Tehran, Iran.
EM rmeshkani@tums.ac.ir
RI Shabani, Maryam/AAC-9458-2022; Hosseini, Hossein/AAX-5350-2021; Koushki,
   Mehdi/ABF-6819-2020; teimouri, maryam/AAO-9967-2021
OI Teimouri, Maryam/0000-0002-3904-3951
FU Tehran University of Medical Sciences and Health Services
   [96-01-30-33971]
FX Tehran University of Medical Sciences and Health Services, Grant/Award
   Number: grant 96-01-30-33971
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NR 46
TC 37
Z9 40
U1 0
U2 23
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1521-6543
EI 1521-6551
J9 IUBMB LIFE
JI IUBMB Life
PD MAR
PY 2020
VL 72
IS 3
BP 361
EP 372
DI 10.1002/iub.2221
EA DEC 2019
PG 12
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA KM9XA
UT WOS:000504874900001
PM 31889412
OA Bronze
DA 2025-06-11
ER

PT J
AU Mohammed, SG
   Ibrahim, IAAEH
   Mahmoud, MF
   Mahmoud, AAA
AF Mohammed, Samar G.
   Ibrahim, Islam A. A. E-H
   Mahmoud, Mona F.
   Mahmoud, Amr A. A.
TI Carvedilol protects against hepatic ischemia/reperfusion injury in
   high-fructose/high-fat diet-fed mice: Role of G protein-coupled receptor
   kinase 2 and 5
SO TOXICOLOGY AND APPLIED PHARMACOLOGY
LA English
DT Article
DE Hepatic ischemia/reperfusion; beta-arrestin; Carvedilol; GRK2; GRK5
ID ISCHEMIA-REPERFUSION INJURY; NF-KAPPA-B; BETA-ADRENERGIC-RECEPTOR;
   INSULIN-RESISTANCE; PHOSPHOLIPASE-C; NITRIC-OXIDE; METABOLIC SYNDROME;
   ARRESTIN; ACTIVATION; RAT
AB Hepatic ischemia/reperfusion injury (H-IRI) is associated with irreversible liver damage. The current study aimed to investigate the protective effect of carvedilol against H-IRI in high-fructose high-fat diet (HFrHFD)-fed mice and the role of G protein-coupled receptor kinase 2 and 5 (GRK2 and GRK5). Mice were fed HFrHFD for 16 weeks; then mice were subjected to 30 min of ischemia followed by 1 h of reperfusion at the end of feeding period. Carvedilol (20 mg/kg, i.p.) was administered 30 min before ischemia. To explore the role of GRK2 and GRK5 in mediating carvedilol effects, paroxetine (GRK2 inhibitor, 10 mg/kg, i.p.) and amlexanox (GRK5 inhibitor, 25 mg/kg, i.p.) were administered 30 min before carvedilol administration. Liver function, histopathology and hepatic oxidative stress, as well as inflammatory and apoptotic markers were measured at the end of the experiment. In addition, adrenergic receptor downstream signals were measured in the liver. Results showed increased markers of liver injury (ALT and AST) in mice subjected to H-IRI. Moreover, liver injury was associated with slight collagen deposits as revealed by histopathology and elevated hepatic levels of oxidative stress, inflammatory and apoptotic markers. On the other hand, carvedilol protected mice against H-IFtI and improved all associated pathological changes. Furthermore, pre-injection of either GRK2 or GRK5 inhibitor did not change carvedilol effects on serum ALT level and liver collagen deposits, while increased its antioxidant, anti-inflammatory and anti-apoptotic effects. In conclusion, carvedilol protects against H-IRI in HFrHFD-fed mice. GRK2 and GRK5 may not play a potential role in mediating this effect.
C1 [Mohammed, Samar G.; Ibrahim, Islam A. A. E-H; Mahmoud, Mona F.; Mahmoud, Amr A. A.] Zagazig Univ, Fac Pharm, Dept Pharmacol & Toxicol, Zagazig 44519, Egypt.
   [Mohammed, Samar G.] Minist Justice, Medicolegal Org, Cairo Lab, Dept Tox & Narcot Drugs,Forens Med, Cairo, Egypt.
C3 Egyptian Knowledge Bank (EKB); Zagazig University; Ministry of Justice -
   Egypt
RP Mahmoud, AAA (corresponding author), Oman Coll Hlth Sci, Dept Pharmacol, Pharm Program, Muscat 114, Oman.
EM aamahmoud@pharmacy.zu.edu.eg
RI Mahmoud, Mona/Q-8851-2019; Mohammed, Samar/HTP-8905-2023; Mahmoud,
   Amr/Y-7062-2019; Ibrahim, Islam/ABG-3068-2020
OI Ibrahim, Islam/0000-0002-8931-465X; Mahmoud, Mona/0000-0002-5312-2066;
   Mahmoud, Amr/0000-0003-2959-0692
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NR 72
TC 12
Z9 13
U1 1
U2 5
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0041-008X
EI 1096-0333
J9 TOXICOL APPL PHARM
JI Toxicol. Appl. Pharmacol.
PD NOV 1
PY 2019
VL 382
AR 114750
DI 10.1016/j.taap.2019.114750
PG 10
WC Pharmacology & Pharmacy; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Toxicology
GA JM2FS
UT WOS:000496036800012
PM 31518596
DA 2025-06-11
ER

EF﻿FN Clarivate Analytics Web of Science
VR 1.0
PT J
AU Jarkas, DA
   Robillard, R
   Malenfant, CR
   Richards, C
   Lanthier, M
   Beaurepaire, C
   Nicholson, AA
   Jaworska, N
   Cassidy, CM
   Shlik, J
   Kaminsky, Z
   Mcquaid, RJ
AF Jarkas, Dana A.
   Robillard, Rebecca
   Malenfant, Claude-Richard
   Richards, Carley
   Lanthier, Malika
   Beaurepaire, Cecile
   Nicholson, Andrew A.
   Jaworska, Natalia
   Cassidy, Clifford M.
   Shlik, Jakov
   Kaminsky, Zachary
   Mcquaid, Robyn J.
TI Exploring the dissociative subtype of PTSD: The role of early-life
   trauma, cortisol, and inflammatory profiles
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE Childhood trauma; Cortisol; Cytokines; Dissociative PTSD; Post-traumatic
   stress disorder; Inflammation
ID POSTTRAUMATIC-STRESS-DISORDER; C-REACTIVE PROTEIN; METABOLIC SYNDROME;
   CHILD-ABUSE; SYMPTOMS; DEPRESSION; VETERANS; ASSOCIATION; PREVALENCE;
   VIOLENCE
AB Post-traumatic stress disorder (PTSD) is a heterogeneous mental health condition, characterized by diverse symptom profiles and biological underpinnings. A dissociative subtype of PTSD has been identified, though the potential risk factors and underlying neurobiology are yet to be understood. The current study comprised Canadian Armed Forces (CAF) members and Veterans with a history of deployment, and with diagnoses of nondissociative (n = 31) and dissociative subtypes of PTSD (n = 19), in addition to non-deployed healthy controls (n =14). Participants completed questionnaires assessing clinical symptoms and experiences of trauma, and provided saliva and blood samples for cortisol and inflammatory marker assessments. Individuals with dissociative PTSD displayed elevated PTSD and depression symptom severity, and greater reports of specific forms of childhood trauma compared to individuals with non-dissociative PTSD and controls. Morning cortisol was elevated in both PTSD groups compared to controls, however the PTSD groups did not differ from one another. Evening cortisol concentrations were elevated in both PTSD groups compared to controls, and in the dissociative PTSD subtype compared to the non-dissociative PTSD subtype when controlling for depression symptoms. PTSD diagnostic group moderated the relationship between awakening cortisol levels and PTSD symptom severity, such that the non-dissociative PTSD group displayed a negative correlation between awakening cortisol levels and PTSD symptom severity, while no significant relation was identified in the dissociative PTSD group. Creactive protein (CRP) levels did not differ across diagnostic groups when accounting for body mass index (BMI). However, CRP positively correlated with depressive symptoms only among individuals with dissociative PTSD. Together, examining PTSD subtypes may help inform more effective and personalized treatment strategies in the future.
C1 [Jarkas, Dana A.; Jaworska, Natalia; Mcquaid, Robyn J.] Carleton Univ, Dept Neurosci, 1125 Colonel By Dr, Ottawa, ON K1S 5B6, Canada.
   [Jarkas, Dana A.; Robillard, Rebecca; Malenfant, Claude-Richard; Richards, Carley; Lanthier, Malika; Beaurepaire, Cecile; Nicholson, Andrew A.; Jaworska, Natalia; Cassidy, Clifford M.; Kaminsky, Zachary; Mcquaid, Robyn J.] Univ Ottawa, Inst Mental Hlth Res The Royal, 1145 Carling Ave, Ottawa, ON K1Z7K4, Canada.
   [Robillard, Rebecca; Malenfant, Claude-Richard; Lanthier, Malika; Nicholson, Andrew A.; Jaworska, Natalia; Cassidy, Clifford M.; Mcquaid, Robyn J.] Univ Ottawa, Sch Psychol, 75 Laurier Ave E, Ottawa, ON K1N 6N5, Canada.
   [Nicholson, Andrew A.] Atlas Inst Vet & Families, 1145 Carling Ave, Ottawa, ON K1Z 7K4, Canada.
   [Cassidy, Clifford M.] SUNY Stony Brook, Renaissance Sch Med, 100 Nicolls Rd, Stony Brook, NY 11794 USA.
   [Shlik, Jakov] Royal Ottawa Mental Hlth Ctr, 1145 Carling Ave, Ottawa, ON K1Z 7K4, Canada.
C3 Carleton University; University of Ottawa; University of Ottawa; State
   University of New York (SUNY) System; Stony Brook University; Stony
   Brook University Hospital; University of Ottawa
RP Jarkas, DA; Mcquaid, RJ (corresponding author), Carleton Univ, Dept Neurosci, 1125 Colonel By Dr, Ottawa, ON K1S 5B6, Canada.
EM danajarkas@cmail.carleton.ca; robynmcquaid@cunet.carleton.ca
RI Cassidy, Clifford/AAW-1300-2021; Nicholson, Andrew/AAA-6598-2021;
   McQuaid, Robyn/ABB-4143-2021
FU Canadian Department of National Defence via the Innovation for Defence
   Excellence and Se-curity program
FX This work was supported by funding from the Canadian Department of
   National Defence via the Innovation for Defence Excellence and Se-curity
   program.
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NR 116
TC 0
Z9 0
U1 2
U2 2
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
EI 1873-3360
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD MAY
PY 2025
VL 175
AR 107406
DI 10.1016/j.psyneuen.2025.107406
EA FEB 2025
PG 12
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA 0CR0E
UT WOS:001444214900001
PM 40010078
OA hybrid
DA 2025-06-11
ER

PT J
AU Awan, UN
   Waraich, RS
   Nangrejo, R
   Noor, SS
   Siddiqui, IA
   Ikram, K
AF Awan, U. N.
   Waraich, R. S.
   Nangrejo, R.
   Noor, S. S.
   Siddiqui, I. A.
   Ikram, K.
TI RAGE signalling contributes to oxidative stress and inflammation in knee
   osteoarthritis patients with metabolic syndrome
SO CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
LA English
DT Article
DE knee osteoarthritis; receptor for advanced glycation end products;
   HMGB-1; NADPH; oxidative stress
ID GLYCATION END-PRODUCTS; NADPH OXIDASE; RECEPTOR; ACTIVATION;
   CHONDROCYTES; EXPRESSION; PROTEIN; CELLS
AB Objective Metabolic factors play significant role in the natural history of knee osteoarthritis (KO). There is a limited understanding of molecular and cellular events that give rise to the disease in patients. This study explored the possible cellular mechanisms by which metabolic syndrome leads to KO. Methods This cross-sectional study enrolled 80 subjects with KO who fulfilled the ACR diagnostic criteria and were undergoing total knee replacement surgery. The patients were divided into two groups: KO patients without metabolic syndrome and KO patients with metabolic syndrome. Results We hypothesised that metabolic syndrome may accelerate pathogenesis of OA by enhanced RAGE axis in articular cartilage and Infrapatellar fat pad of the knee joint. We have found enhanced protein expression of receptor for advanced glycation end products (RAGE) and its ligands AGEs and HMGB-1 in knee joint tissue of KO patients with metabolic syndrome as compared to KO patients without metabolic syndrome. Further downstream, the gene expression of oxidative stress regulators such as NADPH and inflammation, NF & kgreen;B were upregulated in KO patients with MetS as compared to KO patients alone. Higher levels of advanced oxidation products and inflammatory marker IL-17 were exhibited in synovial fluid of KO patients with metabolic syndrome. The enhanced levels of these oxidative stress and inflammatory markers were reflected in the serum of KO patients with metabolic syndrome as well. Conclusion We conclude that enhanced function of RAGE axis could be one of the mechanisms by which metabolic syndrome leads to KO.
C1 [Awan, U. N.] Baqai Med Univ, Dept Anat, Karachi, Pakistan.
   [Waraich, R. S.] Sohail Univ, Biomed Res Ctr, Dept Biomed & Biol Sci, 22-23 Shaheed e millat Rd, Karachi 75080, Pakistan.
   [Nangrejo, R.] Baqai Med Univ, Dept Physiol, Karachi, Pakistan.
   [Noor, S. S.] Medicare Cardiac & Gen Hosp, Dept Orthopaed, Karachi, Pakistan.
   [Siddiqui, I. A.] Baqai Med Univ, Dept Biochem, Karachi, Pakistan.
   [Ikram, K.] Baqai Med Univ, Dept Oral & Maxillofacial Surg, Karachi, Pakistan.
   [Waraich, R. S.] Sohail Univ, Biomed Res Ctr, Dept Biomed & Biol Sci, Karachi 78400, Pakistan.
C3 Baqai Medical University; Baqai Medical University; Baqai Medical
   University; Baqai Medical University
RP Waraich, RS (corresponding author), Sohail Univ, Biomed Res Ctr, Dept Biomed & Biol Sci, 22-23 Shaheed e millat Rd, Karachi 75080, Pakistan.; Waraich, RS (corresponding author), Sohail Univ, Biomed Res Ctr, Dept Biomed & Biol Sci, Karachi 78400, Pakistan.
EM rizwanas.waraich@gmail.com
RI Nangrejo, Ruqaya/JJC-7021-2023; waraich, rizwana/A-8470-2012
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TC 1
Z9 1
U1 2
U2 4
PU CLINICAL & EXPER RHEUMATOLOGY
PI PISA
PA VIA SANTA MARIA 31, 56126 PISA, ITALY
SN 0392-856X
EI 1593-098X
J9 CLIN EXP RHEUMATOL
JI Clin. Exp. Rheumatol.
PD NOV
PY 2024
VL 42
IS 11
BP 2258
EP 2264
PG 7
WC Rheumatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Rheumatology
GA L6T3X
UT WOS:001352017900015
PM 39008290
DA 2025-06-11
ER

PT J
AU Monserrat-Mesquida, M
   Quetglas-Llabrés, MM
   Bouzas, C
   García, S
   Mateos, D
   Ugarriza, L
   Gómez, C
   Tur, JA
   Sureda, A
AF Monserrat-Mesquida, Margalida
   Quetglas-Llabres, Maria Magdalena
   Bouzas, Cristina
   Garcia, Silvia
   Mateos, David
   Ugarriza, Lucia
   Gomez, Cristina
   Tur, Josep A.
   Sureda, Antoni
TI Effects of Regular Exercise on the Biochemical, Oxidative, and
   Inflammatory Profiles and Quality of Life in Older Spaniards with
   Metabolic Syndrome
SO ANTIOXIDANTS
LA English
DT Article
DE metabolic syndrome; exercise; inflammation; quality of life; adults
ID CARDIOVASCULAR RISK; PHYSICAL-ACTIVITY; OBESITY
AB Metabolic syndrome increases the risk of developing diabetes and cardiovascular disease. The regular practice of physical activity is a crucial factor for healthy aging and for controlling and preventing chronic diseases. To assess the effects of regular physical activity on the biochemical and inflammatory profiles, as well as the quality of life of older adults diagnosed with metabolic syndrome. Participants (aged 55-70 years; living in the Balearic Islands, Spain) were divided into two groups (n = 50 each) according to the degree of physical activity measured by metabolic equivalents of task (METs). Anthropometric parameters, blood pressure, biochemical and hematological parameters, and inflammatory biomarkers were measured. Beck Depression Inventory and adherence to the Mediterranean diet questionnaires, as well as the Dietary Inflammatory Index, chair test, health-related quality of life (HRQoL), and Rapid Assessment of Physical Activity, were also determined. The characterization of the patients was similar in both groups, showing a homogeneous sample. The group with the highest METs experienced a decrease in depression and an increase in the intensity of physical activity. Adherence to the Mediterranean diet and HRQoL physical dimensions increased in participants with the highest METs, also showing a decrease in glycemia and glycosylated hemoglobin values. Inflammatory biomarkers, including tumor necrosis factor alpha, interleukin-6, interleukin-1 beta, and osteoprotegerin, decreased in patients practicing more physical activity. High levels of physical activity are related to a healthier lifestyle, characterized by high adherence to the Mediterranean diet, decreased depressive behavior, oxidative stress, and inflammatory status in older people with metabolic syndrome.
C1 [Monserrat-Mesquida, Margalida; Quetglas-Llabres, Maria Magdalena; Bouzas, Cristina; Garcia, Silvia; Mateos, David; Ugarriza, Lucia; Gomez, Cristina; Tur, Josep A.; Sureda, Antoni] Univ Balear Isl, Res Grp Community Nutr & Oxidat Stress, IUNICS, Palma de Mallorca 07122, Spain.
   [Monserrat-Mesquida, Margalida; Quetglas-Llabres, Maria Magdalena; Bouzas, Cristina; Garcia, Silvia; Mateos, David; Ugarriza, Lucia; Tur, Josep A.; Sureda, Antoni] Inst Salud Carlos III, CIBEROBN Physiopathol Obes & Nutr, E-28029 Madrid, Spain.
   [Monserrat-Mesquida, Margalida; Quetglas-Llabres, Maria Magdalena; Bouzas, Cristina; Garcia, Silvia; Mateos, David; Ugarriza, Lucia; Gomez, Cristina; Tur, Josep A.; Sureda, Antoni] Hlth Res Inst Balear Isl IdISBa, E-07120 Palma de Mallorca, Spain.
   [Ugarriza, Lucia] IBSalut, CS Camp Redo, E-07010 Palma de Mallorca, Spain.
   [Gomez, Cristina] Hosp Univ Son Espases, Clin Anal Serv, Palma de Mallorca 07120, Spain.
C3 Universitat de les Illes Balears; IUNICS; CIBER - Centro de
   Investigacion Biomedica en Red; CIBEROBN; Instituto de Salud Carlos III;
   Institut Investigacio Sanitaria Illes Balears (IdISBa); Hospital
   Universitari Son Espases
RP Tur, JA (corresponding author), Univ Balear Isl, Res Grp Community Nutr & Oxidat Stress, IUNICS, Palma de Mallorca 07122, Spain.; Tur, JA (corresponding author), Inst Salud Carlos III, CIBEROBN Physiopathol Obes & Nutr, E-28029 Madrid, Spain.; Tur, JA (corresponding author), Hlth Res Inst Balear Isl IdISBa, E-07120 Palma de Mallorca, Spain.
EM margalida.monserrat@uib.es; pep.tur@uib.es
RI Sureda, Antoni/N-9588-2019; Quetglas Llabrés, Maria/AAA-4412-2019;
   Bouzas, Cristina/AAE-2069-2019; Tur, Josep/AAE-5748-2020; Mesquida,
   Margalida/AAB-4773-2019; Tur, Josep/F-5576-2014
OI Bouzas Velasco, Cristina/0000-0002-1407-8461; Quetglas Llabres, Maria
   Magdalena/0000-0003-4155-7780; Tur, Josep/0000-0002-6940-0761; ,
   Antoni/0000-0001-8656-6838; Garcia, Silvia/0000-0003-3534-1588; GOMEZ
   COBO, CRISTINA/0000-0002-9776-4730; Monserrat Mesquida,
   Margalida/0000-0002-8856-135X
FU Instituto de Salud Carlos III through the Fondo de Investigacin para la
   Salud; CIBEROBN is an initiative of Instituto de Salud Carlos III, Spain
FX The authors especially thank the participants for their enthusiastic
   collaboration and the personnel for their outstanding support and
   exceptional efforts. CIBEROBN is an initiative of Instituto de Salud
   Carlos III, Spain.
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NR 52
TC 2
Z9 2
U1 0
U2 1
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD APR
PY 2024
VL 13
IS 4
AR 450
DI 10.3390/antiox13040450
PG 13
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA OX1B2
UT WOS:001210474300001
PM 38671898
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Tosco, A
   Marino, D
   Polizzi, S
   Tradati, V
   Padoan, R
   Giust, C
   Fabrizzi, B
   Taccetti, G
   Merli, L
   Terlizzi, V
AF Tosco, Antonella
   Marino, Diletta
   Polizzi, Sara
   Tradati, Valentina
   Padoan, Rita
   Giust, Claudia
   Fabrizzi, Benedetta
   Taccetti, Giovanni
   Merli, Lucia
   Terlizzi, Vito
TI A Multicentre Italian Study on the Psychological Impact of an
   Inconclusive Cystic Fibrosis Diagnosis after Positive Neonatal Screening
SO CHILDREN-BASEL
LA English
DT Article
DE newborn screening; Cystic Fibrosis transmembrane conductance
   regulator-related metabolic syndrome (CRMS); Cystic Fibrosis
   screen-positive inconclusive diagnosis (CFSPID); psychological impact
AB Background: An inconclusive diagnosis of cystic fibrosis (CF) after positive newborn screening (NBS) may cause parental distress. We compared the psychological impact of CF transmembrane conductance regulator-related metabolic syndrome (CRMS)/CF screen-positive, inconclusive diagnosis (CFSPID), and clear CF diagnosis, on parents. Methods: The participants were administered the Generalized Anxiety Disorder Scale, Patient Health Questionnaire-9, and the Italian version of the Impact of Event Scale-Revised as quantitative tools and semi-structured interviews as qualitative tools. Parental experience, child representation, relationships, future information, and perception of health status were investigated. Interviews were recorded and transcribed verbatim maintaining anonymity. Results: Thirty-two families were enrolled: sixteen with CF and CRMS/CFSPID, respectively. Anxiety and depression values were high in both groups, as were the measurement of traumatic impact subscales: avoidance, intrusiveness, and hyperarousal. The children's health was evaluated by respective parents as being nearly healthy. Conclusions: Our results highlight negative psychological impacts, including emotional and affective representations, on parents of children with inconclusive CF diagnosis compared with those with clear diagnosis.
C1 [Tosco, Antonella; Polizzi, Sara] Univ Naples Federico II, Cyst Fibrosis Reg Reference Ctr, Dept Translat Med Sci, Paediat Unit, I-80131 Naples, Italy.
   [Marino, Diletta] Freelance Psychologist, I-50139 Florence, Italy.
   [Tradati, Valentina; Padoan, Rita] Univ Brescia, Cyst Fibrosis Reg Support Ctr, ASST Spedali Civili Brescia, I-25123 Brescia, Italy.
   [Padoan, Rita] Sci Board Italian CF Registry, I-00100 Rome, Italy.
   [Giust, Claudia; Fabrizzi, Benedetta] United Hosp, Cyst Fibrosis Reg Reference Ctr, Mother Child Dept, I-60131 Ancona, Italy.
   [Taccetti, Giovanni; Terlizzi, Vito] Meyer Childrens Hosp IRCCS, Cyst Fibrosis Reg Reference Ctr, Dept Paediat Med, Viale Gaetano Pieraccini 24, I-50139 Florence, Italy.
   [Merli, Lucia] Azienda Sanit Toscana Ctr, Palliat Care Unit, I-50100 Florence, Italy.
C3 University of Naples Federico II; Hospital Spedali Civili Brescia;
   University of Brescia
RP Tosco, A (corresponding author), Univ Naples Federico II, Cyst Fibrosis Reg Reference Ctr, Dept Translat Med Sci, Paediat Unit, I-80131 Naples, Italy.; Terlizzi, V (corresponding author), Meyer Childrens Hosp IRCCS, Cyst Fibrosis Reg Reference Ctr, Dept Paediat Med, Viale Gaetano Pieraccini 24, I-50139 Florence, Italy.
EM antonellatosco@gmail.com; vito.terlizzi@meyer.it
RI Taccetti, Giovanni/LXW-7489-2024; Padoan, Rita/AAV-2841-2021; TOSCO,
   Antonella/U-7052-2017; Terlizzi, Vito/AAH-6748-2019; Taccetti,
   Giovanni/K-9519-2016
OI Terlizzi, Vito/0000-0003-1106-4424; Padoan, Rita/0000-0002-0624-8125;
   Taccetti, Giovanni/0000-0002-9448-5381
FU Italian cystic fibrosis Research Foundation-project FFC; Delegazione FFC
   di Monterotondo Roma
FX This study was funded by the Italian cystic fibrosis Research
   Foundation-project FFC#30/2018 and FFC#24/2020, with the contribution of
   Delegazione FFC di Siena, Delegazione FFC di Monterotondo Roma,
   Delegazione FFC di Olbia (FFC#30/2018), Delegazione FFC di Acqui Terme
   (FFC#24/2020).
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NR 30
TC 8
Z9 8
U1 0
U2 3
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2227-9067
J9 CHILDREN-BASEL
JI Children-Basel
PD FEB
PY 2023
VL 10
IS 2
AR 177
DI 10.3390/children10020177
PG 11
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA 9H6OB
UT WOS:000938948900001
PM 36832306
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Rosa, D
   Terzoni, S
   Dellafiore, F
   Destrebecq, A
AF Rosa, D.
   Terzoni, S.
   Dellafiore, F.
   Destrebecq, A.
TI Systematic review of shift work and nurses' health
SO OCCUPATIONAL MEDICINE-OXFORD
LA English
DT Review
DE Breast neoplasm; cardiovascular disease; diabetes mellitus; metabolic
   syndrome; sleep disorders
ID NIGHT WORK; STRESS; SLEEP; RISK
AB Background Nursing is characterized by a working articulation in shifts to ensure continuity of care throughout the 24 h. However, shift work and the resulting desynchronization of circadian rhythms may have adverse effects on nurses' health.
   Aims To describe the effects of shift work and desynchronization of circadian rhythms on nurse's health.
   Methods Databases: PubMed, Cinahl, Scopus, Embase and Ilisi. Search terms (free terms, MeSH): 'nurses', 'shiftwork', 'nightwork', 'sleep disorder, circadian rhythm', 'work schedule tolerance', 'breast neoplasm', 'metabolic syndrome X', 'metabolic cardiovascular syndrome', 'Cardiovascular disease', 'stress', 'diabetes'. We included all randomized controlled trials, observational studies, reviews and papers studying nurses' shift work. Quality assessment of the retrieved papers was verified according to Dixon-Woods checklist.
   Results Twenty-four articles were analyzed. Literature review has shown that shift work involves an alteration in psychophysical homeostasis, with a decrease in performance. It is an obstacle for social and family relationships, as well as a risk factor for stress, sleep disorders, metabolic disorders, diabetes, cardiovascular disorders and breast cancer.
   Conclusions An organized ergonomic turnaround can be less detrimental to the health of nurses and more beneficial for the healthcare providers. Therefore, we suggest organizing studies to assess whether improving nurses' health would lead to a reduction in miscarriages, absenteeism and work-related stress.
C1 [Rosa, D.] Univ Roma Tor Vergata, Dept Biomed & Prevent, I-00133 Rome, Italy.
   [Terzoni, S.] San Paolo Teaching Hosp, San Paolo Bachelor Sch Nursing, I-20142 Milan, Italy.
   [Dellafiore, F.] IRCCS Policlin, Hlth Profess Res & Dev Unit, I-20097 San Donato Milanese, Italy.
   [Destrebecq, A.] Univ Milan, Dept Biomed Sci Hlth, I-20122 Milan, Italy.
C3 University of Rome Tor Vergata; IRCCS Policlinico San Donato; University
   of Milan
RP Rosa, D (corresponding author), Univ Roma Tor Vergata, Via Montpellier 1, I-00133 Rome, Italy.
EM debora.rosa@unimi.it
RI Terzoni, Stefano/AAH-7582-2021; Destrebecq, Anne/L-7920-2016; Federica,
   Dellafiore/AAB-3964-2021; Rosa, Debora/AAG-8957-2021
OI Rosa, Debora/0000-0002-1440-3092; Terzoni, Stefano/0000-0002-0716-5663
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NR 32
TC 142
Z9 151
U1 7
U2 64
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0962-7480
EI 1471-8405
J9 OCCUP MED-OXFORD
JI Occup. Med.-Oxf.
PD JUN
PY 2019
VL 69
IS 4
BP 237
EP 243
DI 10.1093/occmed/kqz063
PG 7
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA JH8WR
UT WOS:000493049300004
PM 31132107
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Morris, G
   Puri, BK
   Walker, AJ
   Maes, M
   Carvalho, AF
   Bortolasci, CC
   Walder, K
   Berk, M
AF Morris, Gerwyn
   Puri, Basant K.
   Walker, Adam J.
   Maes, Michael
   Carvalho, Andre F.
   Bortolasci, Chiara C.
   Walder, Ken
   Berk, Michael
TI Shared pathways for neuroprogression and somatoprogression in
   neuropsychiatric disorders
SO NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
LA English
DT Review
DE Non-Communicable disorders; Psychiatry; Mental disorders; Obesity;
   Metabolic syndrome; Disease progression; Staging; Diabetes;
   Cardiovascular disease; Inflammation; Oxidative stress; Pathophysiology;
   Treatment; Aetiology
ID BODY-MASS INDEX; NF-KAPPA-B; ADIPOSE-TISSUE INFLAMMATION; ACTIVATED
   PROTEIN-KINASE; HEPATIC INSULIN-RESISTANCE; MAJOR DEPRESSIVE DISORDER;
   TYPE-2 DIABETES-MELLITUS; NITROSATIVE STRESS PATHWAYS;
   TYROSINE-PHOSPHATASE 1B; SEVERE MENTAL-ILLNESS
AB Activated immune-inflammatory, oxidative and nitrosative stress (IO&NS) pathways and consequent mitochondrial aberrations are involved in the pathophysiology of psychiatric disorders including major depression, bipolar disorder and schizophrenia. They offer independent and shared contributions to pathways underpinning medical comorbidities including insulin resistance, metabolic syndrome, obesity and cardiovascular disease - herein conceptualized as somatoprogression. This narrative review of human studies aims to summarize relationships between IO&NS pathways, neuroprogression and somatoprogression. Activated IO&NS pathways, implicated in the neuroprogression of psychiatric disorders, affect the pathogenesis of comorbidities including insulin resistance, dyslipidaemia, obesity and hypertension, and by inference, metabolic syndrome. These conditions activate IO&NS pathways, exacerbating neuroprogression in psychiatric disorders. The processes whereby proinflammatory cytokines, nitrosative and endoplasmic reticulum stress, NADPH oxidase isoforms, PPAR gamma inactivation, SIRT1 deficiency and intracellular signalling pathways impact lipid metabolism and storage are considered. Through associations between body mass index, chronic neuroinflammation and PTO expression, activation of IO&NS pathways arising from somatoprogression may contribute to neuroprogression. Early evidence highlights the potential of adjuvants targeting IO&NS pathways for treating somatoprogression and neuroprogression.
C1 [Morris, Gerwyn; Walker, Adam J.; Maes, Michael; Berk, Michael] Deakin Univ, Sch Med, IMPACT Strateg Res Ctr, Geelong, Vic, Australia.
   [Puri, Basant K.] Imperial Coll London, Hammersmith Hosp, Dept Med, London, England.
   [Carvalho, Andre F.; Bortolasci, Chiara C.; Walder, Ken; Berk, Michael] Deakin Univ, CMMR Strateg Res Ctr, Sch Med, Geelong, Vic, Australia.
   [Berk, Michael] Univ Melbourne, Dept Psychiat, Natl Ctr Excellence Youth Mental Hlth, Orygen, Parkville, Vic, Australia.
   [Berk, Michael] Univ Melbourne, Florey Inst Neurosci & Mental Hlth, Parkville, Vic, Australia.
   [Carvalho, Andre F.] Univ Toronto, Dept Psychiat, Toronto, ON, Canada.
   [Carvalho, Andre F.] CAMH, Toronto, ON, Canada.
C3 Deakin University; Imperial College London; Deakin University; Orygen,
   The National Centre of Excellence in Youth Mental Health; University of
   Melbourne; Florey Institute of Neuroscience & Mental Health; University
   of Melbourne; University of Toronto; University of Toronto; Centre for
   Addiction & Mental Health - Canada
RP Berk, M (corresponding author), Deakin Univ, Sch Med, IMPACT SRC, POB 281, Geelong, Vic 3220, Australia.
EM michael.berk@barwonhealth.org.au
RI Berk, Michael/AGH-9427-2022; Puri, Basant/H-8249-2019; Maes,
   Michael/B-8546-2011; Carvalho, Andre/AEZ-4001-2022; Berk,
   Michael/M-7891-2013; Bortolasci, Chiara/C-7336-2016
OI Walker, Adam/0000-0002-5399-1245; Berk, Michael/0000-0002-5554-6946;
   Bortolasci, Chiara/0000-0002-0794-6363; Puri, Basant/0000-0001-6101-0139
FU NHMRC [APP1059660, APP1156072]; Trisno Family Fellowship; Alfred Deakin
   Postdoctoral Research Fellowship
FX MB is supported by a NHMRC Senior Principal Research Fellowship
   (APP1059660 and APP1156072). AJW is supported by a Trisno Family
   Fellowship. CCB is supported by an Alfred Deakin Postdoctoral Research
   Fellowship.
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TC 80
Z9 79
U1 0
U2 16
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0149-7634
EI 1873-7528
J9 NEUROSCI BIOBEHAV R
JI Neurosci. Biobehav. Rev.
PD DEC
PY 2019
VL 107
BP 862
EP 882
DI 10.1016/j.neubiorev.2019.09.025
PG 21
WC Behavioral Sciences; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Behavioral Sciences; Neurosciences & Neurology
GA JU0RX
UT WOS:000501388000060
PM 31545987
DA 2025-06-11
ER

PT J
AU Viscogliosi, G
   Andreozzi, P
   Chiriac, IM
   Cipriani, E
   Servello, A
   Marigliano, B
   Ettorre, E
   Marigliano, V
AF Viscogliosi, Giovanni
   Andreozzi, Paola
   Chiriac, Iulia Maria
   Cipriani, Elisa
   Servello, Adriana
   Marigliano, Benedetta
   Ettorre, Evaristo
   Marigliano, Vincenzo
TI Depressive symptoms in older people with metabolic syndrome: is there a
   relationship with inflammation?
SO INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
LA English
DT Article
DE depression; older; metabolic syndrome; low-grade chronic inflammation
ID LATE-LIFE DEPRESSION; C-REACTIVE PROTEIN; ATHEROSCLEROSIS; ASSOCIATION;
   POPULATION; DISEASES; ANXIETY; HEALTH
AB Objective To investigate if there is a higher prevalence of depressive symptoms in older people with metabolic syndrome (MetS) compared with those without and whether dedpressive symptoms are independently associated to MetS and its single components and to the inflammatory markers. Methods Physical parameters, standard blood analytes, high sensitivity C-reactive protein (hsCRP) and erythrocyte sedimentation rate (ESR) were assessed. Fifteen-item Geriatric Depression Scale and mini mental state examination (MMSE) were administered. Results One hundred thirty-three subjects were enrolled. MetS patients (57) exhibited higher prevalence of depressive symptoms (p<0.0001), worse cognitive function (p<0.0001), and higher levels of ESR and hsCRP were higher (p<0.0001). The univariate analysis showed a linear strong correlation of depressive symptoms (p<0.0001) with the MMSE score (r=0.422), body mass index (r=0.414), MetS (r=0.582), number of MetS components (r=0.663), fasting blood glucose (r=0.565), ESR (r=0.565), hsCRP (r=0.745), central obesity (r=0.269; p=0.002), and high-density lipoprotein cholesterol (r=0.241; p=0.005). However, the multivariate analysis showed that only age (B=0.093; p=0.032), MetS (B=1.446; p=0.025), fasting blood glucose (B=0.039; p=0.005), and hsCRP (B=7.649; p<0.0001) were independently associated with depressive symptoms. Conclusions MetS and inflammation are independently associated with depressive symptoms in older people. Inflammation may explain cognitive decline too. Further investigations are needed to better understand the direction of these associations and to determine whether these can be reversible. Copyright (c) 2012 John Wiley & Sons, Ltd.
C1 [Viscogliosi, Giovanni; Andreozzi, Paola; Chiriac, Iulia Maria; Cipriani, Elisa; Servello, Adriana; Marigliano, Benedetta; Ettorre, Evaristo; Marigliano, Vincenzo] Univ Roma La Sapienza, Predict Med Unit, Dept Cardiovasc Resp Nephrol & Geriatr Sci, Rome, Italy.
C3 Sapienza University Rome
RP Viscogliosi, G (corresponding author), Univ Roma La Sapienza, Predict Med Unit, Dept Cardiovasc Resp Nephrol & Geriatr Sci, Rome, Italy.
EM giovanni.viscogliosi@libero.it
OI Andreozzi, Paola/0000-0003-0369-8750; ettorre,
   evaristo/0000-0002-8247-3308; Servello, Adriana/0000-0002-8197-5904
CR Bertoni AG, 2010, DIABETES CARE, V33, P804, DOI 10.2337/dc09-1679
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NR 22
TC 44
Z9 48
U1 0
U2 23
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0885-6230
EI 1099-1166
J9 INT J GERIATR PSYCH
JI Int. J. Geriatr. Psychiatr.
PD MAR
PY 2013
VL 28
IS 3
BP 242
EP 247
DI 10.1002/gps.3817
PG 6
WC Geriatrics & Gerontology; Gerontology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Psychiatry
GA 087HJ
UT WOS:000314751800004
PM 22639424
DA 2025-06-11
ER

PT J
AU Diana, MA
   Claudia, T
   Georgiana, PM
   Gabriela, D
   Ruxandra, R
   Florica, CA
   Stefania, MN
   Ioana, BR
AF Diana, Maierean Anca
   Claudia, Tonca
   Georgiana, Perne Mirela
   Gabriela, Dogaru
   Ruxandra, Rajnoveanu
   Florica, Chis Ana
   Stefania, Motoc Nicoleta
   Ioana, Bordea Roxana
TI Music, A "Body-Mind Medicine" In Rehabilitation Programs of Patients
   with Chronic Obstructive Pulmonary Disease
SO BALNEO RESEARCH JOURNAL
LA English
DT Article
DE COPD; music therapy; alternative medicine
ID AIR-POLLUTION; LUNG-FUNCTION; RISK-FACTOR; COPD; EXERCISE;
   COMORBIDITIES; DEPRESSION; THERAPY; ANXIETY; IMPACT
AB Chronic obstructive pulmonary disease (COPD) is a progressive disease characterized by dyspnea and chronic cough. The main risk factor is cigarette smoking, but there are other ones implicated in the COPD etiology such as air pollution, childhood asthma, aging, chemical exposure, dietary factors, and genetic predisposition. Besides, COPD is associated with several comorbidities that influence prognostic and management, like asthma, lung cancer, obstructive sleep apnea, cardiovascular disease, metabolic syndrome, and depression or anxiety. The management is multidisciplinary and its role is to ease symptoms, prevent complications, slow disease progression, and improve the quality of life. In the last years, many alternative techniques have been implemented such as speleotherapy, halotherapy, muscular training, neuromuscular electrostimulation, acupuncture, thermotherapy, and music therapy. From those, music therapy has become a form of "mind-body medicine" indispensable in rehabilitation programs, whether used actively or passively, and has gained a lot of interest in alternative medicine.
C1 [Diana, Maierean Anca; Georgiana, Perne Mirela; Gabriela, Dogaru; Ruxandra, Rajnoveanu; Florica, Chis Ana; Stefania, Motoc Nicoleta; Ioana, Bordea Roxana] Iuliu Hatieganu Univ Med & Pharm, Cluj Napoca, Romania.
   [Claudia, Tonca] Clin Hosp Pneumol Leon Daniello Cluj Napoca, Cluj Napoca, Romania.
C3 Iuliu Hatieganu University of Medicine & Pharmacy
RP Georgiana, PM (corresponding author), Iuliu Hatieganu Univ Med & Pharm, Cluj Napoca, Romania.
EM albmirela@yahoo.ro
RI Tonca, Claudia/AAT-3871-2021; Rajnoveanu, Ruxandra/AAE-7159-2021;
   Bordea, Ioana Roxana/AAK-7454-2020
OI Bordea, Ioana Roxana/0000-0001-7166-9949; Tonca,
   Claudia/0000-0002-7864-7256
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NR 83
TC 1
Z9 1
U1 3
U2 10
PU ROMANIAN ASSOC BALNEOLOGY
PI BUCHAREST
PA BUCHAREST, SECTOR 2, ALEEA DOBRINA NO 7, BL D10, SC A, AP 4, BUCHAREST,
   00000, ROMANIA
SN 2069-7597
EI 2069-7619
J9 BALNEO RES J
JI Balneo Res. J.
PD DEC
PY 2020
VL 11
IS 4
BP 435
EP 443
DI 10.12680/balneo.2020.375
PG 9
WC Rehabilitation
WE Emerging Sources Citation Index (ESCI)
SC Rehabilitation
GA PF0QF
UT WOS:000598768600005
OA gold
DA 2025-06-11
ER

PT J
AU Bisson, JF
   Menut, C
   d'Alessio, P
AF Bisson, Jean-Francois
   Menut, Chantal
   d'Alessio, Patrizia
TI Anti-inflammatory senescence actives 5203-L molecule to promote healthy
   aging and prolongation of lifespan
SO REJUVENATION RESEARCH
LA English
DT Article; Proceedings Paper
CT 3rd Conference on Strategies for Engineered Negligible Senescence (SENS)
CY SEP 06-10, 2007
CL Queens Coll, Cambridge, ENGLAND
HO Queens Coll
ID AGENT D-LIMONENE; ENDOTHELIAL-CELLS; NITRIC-OXIDE; PHASE-I; CANCER;
   METABOLITES; LACTOFERRIN; EXPRESSION; STRESS; RAT
AB The aging process depends on genetic stability, metabolic control, and resistance to stress; longevity in particular seems related to resistance to stress. Responses to stress anticipate adaptation to an unacceptable disparity between real or imagined personal experience and expectation, including adaptive stress, anxiety, and depression. However, if stress persists, it may lead to chronic diseases, ranging from inflammation and cancer to degenerative diseases. For some time, only remarkable stress was acknowledged to induce immune and vascular alterations, such as infection or hypertension. Now it is known that moderate stress independent of conventional risk factors can induce a potent alteration of health conditions and consequently shorten life quality and lifespan. Inflammation is a critical defense mechanism, that, uncontrolled, contributes to chronic conditions with inflammatory pathogenesis. Stressful life conditions turn out to induce a diffuse (systemic) pro-inflammatory status. Subclinical chronic inflammation is an important pathogenic factor in the development of metabolic syndrome, a cluster of common pathologies, including cardiovascular disease. Markers include mediators associated with endothelial activation and dysfunction. This work reports the in vitro and in vivo effects of the monoterpene AISA 5203-L on human vascular endothelial cells in reversing replicative senescence in preventing and alleviating nonpathological stress, as assessed by a functional observational battery (FOB) of 44 tests, addressing behavioral, neurological, and physiological criteria.
C1 [Bisson, Jean-Francois] ETAP Appl Ethol, Dept Cancerol & Human Pathol, Vandoeuvre Les Nancy, France.
   [Menut, Chantal] Univ Montpellier, ENSCM, CNRS, Equipe Glycochim,IBMM,UMR 5247,UM1 UM2, F-34059 Montpellier, France.
   [d'Alessio, Patrizia] Genopole Enterprise, AISA Therapeut, Evry, France.
C3 Ecole nationale superieure de chimie de Montpellier; Universite de
   Montpellier; Centre National de la Recherche Scientifique (CNRS); CNRS -
   Institute of Chemistry (INC)
RP d'Alessio, P (corresponding author), CHU Paul Brousse, INSERM, AISA Therapeut, U602, 12 Ave Paul Vaillant Couturier, F-94807 Villejuif, France.
EM dalessio@vjf.inserm.fr
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NR 29
TC 11
Z9 12
U1 0
U2 4
PU MARY ANN LIEBERT INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1549-1684
J9 REJUV RES
JI Rejuv. Res.
PD APR
PY 2008
VL 11
IS 2
BP 399
EP 407
DI 10.1089/rej.2008.0667
PG 9
WC Geriatrics & Gerontology
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA 299RR
UT WOS:000255773200020
PM 18370605
DA 2025-06-11
ER

PT J
AU Sims-Robinson, C
   Bakeman, A
   Glasser, R
   Boggs, J
   Pacut, C
   Feldman, EL
AF Sims-Robinson, Catrina
   Bakeman, Anna
   Glasser, Rebecca
   Boggs, Janet
   Pacut, Crystal
   Feldman, Eva L.
TI The role of endoplasmic reticulum stress in hippocampal insulin
   resistance
SO EXPERIMENTAL NEUROLOGY
LA English
DT Article
DE Metabolic syndrome; Brain; Endoplasmic reticulum stress; Insulin;
   Hippocampus; Apolipoprotein
ID DIET-INDUCED OBESITY; UNFOLDED PROTEIN RESPONSE; ALZHEIMERS-DISEASE;
   COGNITIVE IMPAIRMENT; RECEPTOR SUBSTRATE-1; MOUSE MODELS; METABOLIC
   SYNDROME; DIABETES-MELLITUS; SERINE KINASE; LINKS OBESITY
AB Metabolic syndrome, which includes hypertension, hyperglycemia, obesity, insulin resistance, and dyslipidemia, has a negative impact on cognitive health. Endoplasmic reticulum (ER) stress is activated during metabolic syndrome, however it is not known which factor associated with metabolic syndrome contributes to this stress. ER stress has been reported to play a role in the development of insulin resistance in peripheral tissues. The role of ER stress in the development of insulin resistance in hippocampal neurons is not known. In the current study, we investigated ER stress in the hippocampus of 3 different mouse models of metabolic syndrome: the C57BL6 mouse on a high fat (HF) diet; apolipoprotein E, leptin, and apolipoprotein B-48 deficient (ApoE 3KO) mice; and the low density lipoprotein receptor, leptin, and apolipoprotein B-48 deficient (LDLR 3KO) mice. We demonstrate that ER stress is activated in the hippocampus of HF mice, and for the first time, in ApoE 3KO mice, but not LDLR 3KO mice. The HF and ApoE 3KO mice are hyperglycemic; however, the LDLR 3KO mice have normal glycemia. This suggests that hyperglycemia may play a role in the activation of ER stress in the hippocampus. Similarly, we also demonstrate that impaired insulin signaling is only present in the HF and ApoE 3KO mice, which suggests that ER stress may play a role in insulin resistance in the hippocampus. To confirm this we pharmacologically induced ER stress with thapsigargin in human hippocampal neurons. We demonstrate for the first time that thapsigargin leads to ER stress and impaired insulin signaling in human hippocampal neurons. Our results may provide a potential mechanism that links metabolic syndrome and cognitive health. (C) 2016 Elsevier Inc. All rights reserved.
C1 [Sims-Robinson, Catrina; Bakeman, Anna; Glasser, Rebecca; Pacut, Crystal; Feldman, Eva L.] Univ Michigan, Dept Neurol, Ann Arbor, MI 48109 USA.
   [Sims-Robinson, Catrina; Boggs, Janet] Med Univ S Carolina, Dept Neurol & Neurosurg, Charleston, SC 29425 USA.
C3 University of Michigan System; University of Michigan; Medical
   University of South Carolina
RP Sims-Robinson, C (corresponding author), Med Univ S Carolina, Dept Neurol & Neurosurg, 96 Jonathan Lucas St,309D2 Clin Sci Bldg,MSC 606, Charleston, SC 29445 USA.
EM robinsoc@musc.edu
OI Feldman, Eva/0000-0002-9162-2694; Robinson, Catrina/0000-0003-4776-5839
FU National Institute of Health [NINDS 5K01NS079461]; NIDDK [5-R24-DK-082,
   5-R24-DK-941]; NIA [T32 AG000114]; NINDS Neurology Training Grant [T32
   NS007222]; A. Alfred Taubman Medical Research Institute; Program for
   Neurology Research and Discovery; National Institute of Diabetes and
   Digestive and Kidney Diseases [P30DK020572] Funding Source: NIH
   RePORTER; National Institute of Neurological Disorders and Stroke
   [T32NS007222] Funding Source: NIH RePORTER; National Institute on Aging
   [T32AG000114] Funding Source: NIH RePORTER
FX This work was supported by the National Institute of Health (NINDS
   5K01NS079461, to C. S-R; NIDDK Supplement to 5-R24-DK-082,941, to
   C.S-R.; NIA Training Grant T32 AG000114, to C. S-R.; NINDS Neurology
   Training Grant T32 NS007222, to C. S-R.), the A. Alfred Taubman Medical
   Research Institute, and the Program for Neurology Research and
   Discovery.
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NR 60
TC 27
Z9 29
U1 1
U2 13
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0014-4886
EI 1090-2430
J9 EXP NEUROL
JI Exp. Neurol.
PD MAR
PY 2016
VL 277
BP 261
EP 267
DI 10.1016/j.expneurol.2016.01.007
PG 7
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA DF2ST
UT WOS:000371194800026
PM 26775176
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Curran, K
   Rosenbaum, S
   Parnell, D
   Stubbs, B
   Pringle, A
   Hargreaves, J
AF Curran, Kathryn
   Rosenbaum, Simon
   Parnell, Daniel
   Stubbs, Brendon
   Pringle, Andy
   Hargreaves, Jackie
TI Tackling mental health: the role of professional football clubs
SO SPORT IN SOCIETY
LA English
DT Article
ID PHYSICAL-ACTIVITY INTERVENTIONS; CARDIOVASCULAR RISK-FACTORS; MAJOR
   DEPRESSIVE DISORDER; CARDIORESPIRATORY FITNESS; PSYCHOTIC DISORDERS;
   METABOLIC SYNDROME; WEIGHT-GAIN; PEOPLE; SCHIZOPHRENIA; EXERCISE
AB In the UK, professional football clubs are being used as settings for the delivery of interventions that promote mental health in a number of ways including (i) the delivery of physical activity interventions to improve the mental health of the general population, (ii) the delivery of physical activity interventions for people experiencing mental illness, and (iii) the delivery of community mental health services within the confines of the football club. This research note offers insights into mental health interventions delivered within, and by, professional football clubs and the available evidence concerning their reach, effectiveness and impact. The findings suggest that professional football clubs can help to facilitate access to mental health services, particularly among young people, for whom accessing such services may be highly stigmatized. Furthermore, the findings highlight that such interventions have a positive impact on health. However, in order to capitalize on this opportunity funding agencies and commissioners must provide appropriate resources (human and financial) for effective delivery and evaluation. Furthermore, a more strategic approach to working towards the mental health agenda must be adopted. It is argued that this change in practice would allow professional football clubs to offer those in need access to high-quality interventions.
C1 [Curran, Kathryn; Pringle, Andy; Hargreaves, Jackie] Leeds Beckett Univ, Carnegie Fac, Ctr Act Lifestyles, Leeds, W Yorkshire, England.
   [Rosenbaum, Simon] Univ New South Wales, Dept Exercise Physiol, Fac Med, Sydney, NSW, Australia.
   [Parnell, Daniel] Manchester Metropolitan Univ, Sch Business, Fac Business & Law, Ctr Business & Soc, Manchester, Lancs, England.
   [Stubbs, Brendon] South London & Maudsley NHS Fdn Trust, Physiotherapy Dept, London, England.
   [Stubbs, Brendon] Kings Coll London, Inst Psychiat Psychol & Neurosci, Hlth Serv & Populat Res Dept, London, England.
C3 Leeds Beckett University; University of New South Wales Sydney;
   Manchester Metropolitan University; South London & Maudsley NHS Trust;
   University of London; King's College London
RP Curran, K (corresponding author), Leeds Beckett Univ, Carnegie Fac, Ctr Act Lifestyles, Leeds, W Yorkshire, England.
EM k.m.curran@leedsbeckett.ac.uk
RI Stubbs, Brendon/X-1904-2018; Pringle, Andy/GMW-4159-2022; Rosenbaum,
   Simon/Y-3241-2019; Stubbs, Brendon/C-5696-2015
OI Rosenbaum, Simon/0000-0002-8984-4941; Stubbs,
   Brendon/0000-0001-7387-3791
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NR 66
TC 21
Z9 21
U1 1
U2 31
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 1743-0437
EI 1743-0445
J9 SPORT SOC
JI Sport Soc.
PD FEB
PY 2017
VL 20
IS 2
SI SI
BP 281
EP 291
DI 10.1080/17430437.2016.1173910
PG 11
WC Hospitality, Leisure, Sport & Tourism; Sociology
WE Social Science Citation Index (SSCI)
SC Social Sciences - Other Topics; Sociology
GA EG0DA
UT WOS:000390700000010
OA Green Accepted
DA 2025-06-11
ER

PT J
AU García-Toro, M
   Vicens-Pons, E
   Gili, M
   Roca, M
   Serrano-Ripoll, MJ
   Vives, M
   Leiva, A
   Yáñez, AM
   Bennasar-Veny, M
   Oliván-Blázquez, B
AF Garcia-Toro, M.
   Vicens-Pons, E.
   Gili, M.
   Roca, M.
   Serrano-Ripoll, M. J.
   Vives, M.
   Leiva, A.
   Yanez, A. M.
   Bennasar-Veny, M.
   Olivan-Blazquez, B.
TI Obesity, metabolic syndrome and Mediterranean diet: Impact on depression
   outcome
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Depression; Obesity; Metabolic syndrome; Mediterranean diet
ID MAJOR DEPRESSION; RECOMMENDATIONS
AB Objective: Obesity, metabolic syndrome (MetS) and low adherence to Mediterranean diet are frequent in major depression patients and have been separately related with prognosis. The aim of this study is to analyse their predictive power on major depression outcome, at 6 and 12 months.
   Methods: 273 Major depressive patients completed the Beck Depression Inventory for depressive symptoms and the 14-item Mediterranean diet adherence score. MetS was diagnosed according to the International Diabetes Federation (IDF).
   Results: At the baseline Mediterranean diet adherence was inversely associated with depressive symptoms (p = 0.007). Depression response was more likely in those patients with normal weight (p = 0.006) and not MetS (p=0.013) but it was not associated with Mediterranean diet adherence (p = 0.625). Those patients with MetS and obesity were less likely to improve symptoms of depression than patients with obesity but not MetS.
   Conclusions: Obesity and MetS, but not low adherence to the Mediterranean diet at baseline, predicted a poor outcome of depression at 12 months. Our study suggests that MetS is the key factor that impacts negatively in depression prognosis, rather than obesity or diet. If this finding is confirmed, clinicians should be aware about MetS diagnosis and treatment in overweight depressed patients, especially if outcome is not being satisfactory enough. (C) 2016 Elsevier B.V. All rights reserved.
C1 [Garcia-Toro, M.; Gili, M.; Roca, M.; Serrano-Ripoll, M. J.; Vives, M.; Bennasar-Veny, M.] Univ Balearic Isl, Edifici Guillem Cifre Colonya,Ctra Valldemossa, Palma De Mallorca 07122, Balearic Island, Spain.
   [Garcia-Toro, M.; Vicens-Pons, E.; Gili, M.; Roca, M.; Vives, M.; Olivan-Blazquez, B.] Primary Care Prevent & Hlth Promot Res Network, Barcelona, Spain.
   [Vicens-Pons, E.] Parc Sanitari St Joan de Deu, Psychiat Serv, Barcelona, Spain.
   [Leiva, A.] Inst Invest Sanitaria, Hlth Serv IbSalut, Primary Care Res Unit Mallorca, Mallorca, Spain.
   [Yanez, A. M.] IdISPa, Inst Invest Sanitaria Palma, Palma De Mallorca, Spain.
   [Bennasar-Veny, M.] Univ Balearic Isl, Sch Nursing & Physiotherapy, Dept Nursing, Palma De Mallorca, Illes Balears, Spain.
   [Olivan-Blazquez, B.] Univ Zaragoza, Dept Psychol & Sociol, E-50009 Zaragoza, Spain.
C3 Universitat de les Illes Balears; Atencio Primaria de Mallorca; Institut
   Investigacio Sanitaria Illes Balears (IdISBa); Universitat de les Illes
   Balears; University of Zaragoza
RP Serrano-Ripoll, MJ (corresponding author), Univ Balearic Isl, Edifici Guillem Cifre Colonya,Ctra Valldemossa, Palma De Mallorca 07122, Balearic Island, Spain.
EM mj.serrano@uib.es
RI Leiva, Alfonso/ABF-1361-2020; Oliván-Blázquez, Bárbara/AAS-2130-2020;
   Yañez, Aina/AAF-7087-2021; Garcia-Toro, Mauro/AAL-1153-2020; Roca,
   Miquel/T-9897-2017; Gili, Margalida/H-7680-2013; VIVES BARCELO,
   MARGA/K-1948-2014; Bennasar-Veny, Miquel/C-5881-2008; Serrano-Ripoll,
   Maria J./R-8722-2017
OI Roca, Miquel/0000-0001-7301-8373; Mauro,
   Garcia-Toro/0000-0002-2251-1368; Gili, Margalida/0000-0002-0535-6773;
   VIVES BARCELO, MARGA/0000-0001-6059-0717; leiva,
   Alfonso/0000-0001-5306-8533; Yanez, Aina M/0000-0001-8527-3937;
   Bennasar-Veny, Miquel/0000-0003-1668-2141; Olivan Blazquez,
   Barbara/0000-0001-6565-9699; Serrano-Ripoll, Maria
   J./0000-0002-1869-1132
CR [Anonymous], ACTA PSYCHIAT SCAND
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   Maes M, 2009, METAB BRAIN DIS, V24, P27, DOI 10.1007/s11011-008-9118-1
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   Marazziti D, 2014, CNS SPECTRUMS, V19, P293, DOI 10.1017/S1092852913000667
   Martínez-González MA, 2015, PROG CARDIOVASC DIS, V58, P50, DOI 10.1016/j.pcad.2015.04.003
   Opie RS, 2015, PUBLIC HEALTH NUTR, V18, P2074, DOI 10.1017/S1368980014002614
   Preiss K, 2013, OBES REV, V14, P906, DOI 10.1111/obr.12052
   Rhee SJ, 2014, PROG NEURO-PSYCHOPH, V54, P223, DOI 10.1016/j.pnpbp.2014.06.006
   Ripoll MJS, 2015, J AFFECT DISORDERS, V183, P221, DOI 10.1016/j.jad.2015.04.059
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   Yoshimura R, 2009, PROG NEURO-PSYCHOPH, V33, P722, DOI 10.1016/j.pnpbp.2009.03.020
NR 20
TC 33
Z9 35
U1 3
U2 61
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD APR
PY 2016
VL 194
BP 105
EP 108
DI 10.1016/j.jad.2015.12.064
PG 4
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA DE6DP
UT WOS:000370724200015
PM 26807670
DA 2025-06-11
ER

PT J
AU Chandler, KD
AF Chandler, Kelly D.
TI Work-family conflict is a public health concern
SO PUBLIC HEALTH IN PRACTICE
LA English
DT Article
DE Work-family conflict; Employee health; Occupational health; Work-family
   policies
AB Objectives: The objective of this commentary is to describe how the deleterious health effects of the competing demands of work and family roles are a public health issue that deserves immediate attention.Study design: This is a commentary article; therefore, there is no study design.Method: I reviewed and summarized existing research on work-family conflict as it relates to public health action.Results: Work-to-family conflict (WFC) is pervasive among US working adults and is higher in the US than in other developed countries. Time, energy, and behaviors invested in fulfilling work responsibilities often compete with fulfilling family responsibilities, with numerous deleterious effects on employee health including sleep, cardiometabolic risk, stress, depression, and anxiety. WFC is a potent source of stress for working Americans, a major contributor to healthcare costs, and a predictor of mortality. US policies have lagged woefully behind the increasing competition between work and family demands.Conclusion: Work-to-family conflict is a public health concern that deserves immediate attention. Until governmental support for adults' work and family lives improves, WFC will continue to be a significant risk factor for public health. Including WFC in public health research and interventions will improve population health and advance health equity.
C1 [Chandler, Kelly D.] Oregon State Univ, Human Dev & Family Sci, 410 Waldo Hall, Corvallis, OR 97331 USA.
C3 Oregon State University
RP Chandler, KD (corresponding author), Oregon State Univ, Human Dev & Family Sci, 410 Waldo Hall, Corvallis, OR 97331 USA.
EM Kelly.Chandler@oregonstate.edu
OI Chandler, Kelly/0000-0002-1422-1694
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   Williams JoanC., 2010, The Three Faces of Work-Family Conflict: The Poor, the Professionals
NR 10
TC 21
Z9 21
U1 0
U2 4
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2666-5352
J9 PUBLIC HEALTH PRACT
JI Public Health Pract.
PD NOV
PY 2021
VL 2
AR 100158
DI 10.1016/j.puhip.2021.100158
PG 2
WC Public, Environmental & Occupational Health
WE Emerging Sources Citation Index (ESCI)
SC Public, Environmental & Occupational Health
GA DU2P1
UT WOS:001134530500017
PM 36101589
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Katano, S
   Nakamura, Y
   Nakamura, A
   Suzukamo, Y
   Murakami, Y
   Tanaka, T
   Okayama, A
   Miura, K
   Okamura, T
   Fukuhara, S
   Ueshima, H
AF Katano, Sayuri
   Nakamura, Yasuyuki
   Nakamura, Aki
   Suzukamo, Yoshimi
   Murakami, Yoshitaka
   Tanaka, Taichiro
   Okayama, Akira
   Miura, Katsuyuki
   Okamura, Tomonori
   Fukuhara, Shunichi
   Ueshima, Hirotsugu
TI Relationship between health-related quality of life and clustering of
   metabolic syndrome diagnostic components
SO QUALITY OF LIFE RESEARCH
LA English
DT Article
DE Metabolic syndrome; Diagnostic components; Health-related quality of
   life; SF-36
ID CARDIOVASCULAR RISK-FACTORS; BODY-MASS INDEX; POPULATION STRATEGY;
   INSULIN-RESISTANCE; OBESITY; IMPACT; WOMEN; MEN
AB Purpose To examine the association of the number of metabolic syndrome diagnostic components (MetS-DC) with health-related quality of life (HR-QOL).
   Methods We examined the baseline data from 4,480 healthy workers in Japan (3,668 men and 812 women) aged 19-69 years. We assessed HR-QOL based on scores for five scales of the SF-36. We defined four components for MetS in this study as follows: (1) high blood pressure (BP); (2) dyslipidemia; (3) impaired glucose tolerance; and (4) overweight: a body mass index >= 25 kg/m(2). Logistic regression analysis adjusted for lifestyle factors was used to examine the association of the number of MetS-DC with the HR-QOL sub-scales.
   Results Those who had 0-4 MetS-DC accounted for 2,287, 1,135, 722, 282, and 54 participants. The number of MetS-DC inversely contributed significantly to General Health (norm-based scoring >50) (odd ratios [OR] 0.59-0.82, P < 0.05) and positively associated with Mental Health (OR 1.37, P < 0.05).
   Conclusion When adjusted for lifestyle factors, the number of MetS-DC was inversely associated with General Health and positively with Mental Health in men and women.
C1 [Katano, Sayuri; Nakamura, Yasuyuki; Nakamura, Aki] Kyoto Womens Univ, Higashiyama Ku, Kyoto 6058501, Japan.
   [Nakamura, Yasuyuki; Miura, Katsuyuki; Ueshima, Hirotsugu] Shiga Univ Med Sci, Dept Hlth Sci, Otsu, Shiga 52021, Japan.
   [Suzukamo, Yoshimi] Tohoku Univ, Grad Sch Med, Dept Phys Med & Rehabil, Sendai, Miyagi 980, Japan.
   [Murakami, Yoshitaka] Shiga Univ Med Sci, Dept Med Stat, Otsu, Shiga 52021, Japan.
   [Tanaka, Taichiro] Univ Yamanashi, Interdisciplinary Grad Sch Med & Engn, Dept Hlth Sci, Chuo Ku, Yamanashi, Japan.
   [Okayama, Akira] Japan AntiTB Assoc, Inst Hlth Serv 1, Tokyo, Japan.
   [Okamura, Tomonori] Natl Cardiovasc Ctr, Dept Prevent Cardiol, Suita, Osaka 565, Japan.
   [Fukuhara, Shunichi] Kyoto Univ, Grad Sch Med, Dept Epidemiol & Healthcare Res, Kyoto, Japan.
C3 Kyoto Womens University; Shiga University of Medical Science; Tohoku
   University; Shiga University of Medical Science; University of
   Yamanashi; National Cerebral & Cardiovascular Center - Japan; Kyoto
   University
RP Nakamura, Y (corresponding author), Kyoto Womens Univ, Higashiyama Ku, 35 Imakumano Kitahiyoshi Cho, Kyoto 6058501, Japan.
EM nakamury@kyoto-wu.ac.jp
RI Suzukamo, Yoshimi/T-6500-2019; Suzukamo, Yoshimi/KQU-8600-2024; Okamura,
   Tomonori/L-1693-2013
OI Suzukamo, Yoshimi/0000-0001-7162-4871; Okamura,
   Tomonori/0000-0003-0488-0351; Miura, Katsuyuki/0000-0002-2646-9582
FU Ministry of Health and Welfare of Japan [063, 010]; Ministry of Health,
   Labor, and Welfare of Japan [010]; Japan Arteriosclerosis Prevention
   Fund; National Institutes of Health Research (NIHR) [063] Funding
   Source: National Institutes of Health Research (NIHR)
FX This study was funded by research grants from the Ministry of Health and
   Welfare of Japan (H10-12, No. 063, Research on Health Services, Health
   Sciences Research Grants and H13, No. 010, Medical Frontier Strategy
   Research, Health Sciences Research Grants), the Ministry of Health,
   Labor, and Welfare of Japan (H14-15, No. 010, Clinical Research for
   Evidence-Based Medicine, Health, and Labor Sciences Research Grants),
   and the Japan Arteriosclerosis Prevention Fund 2004. We thank Toshimi
   Yoshida, Shiga University of Medical Science, for her excellent clerical
   support during this research.
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NR 31
TC 22
Z9 23
U1 0
U2 4
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0962-9343
EI 1573-2649
J9 QUAL LIFE RES
JI Qual. Life Res.
PD SEP
PY 2012
VL 21
IS 7
BP 1165
EP 1170
DI 10.1007/s11136-011-0029-y
PG 6
WC Health Care Sciences & Services; Health Policy & Services; Public,
   Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services; Public, Environmental & Occupational
   Health
GA 089KV
UT WOS:000314910300006
PM 21984466
DA 2025-06-11
ER

PT J
AU Ertekin, H
   Sahin, B
   Caliskan, AM
   Inanli, I
   Ertekin, YH
AF Ertekin, Hulya
   Sahin, Basak
   Caliskan, Ali Metehan
   Inanli, Ikbal
   Ertekin, Yusuf Haydar
TI Metabolic syndrome and vaspin in patients with bipolar disorder
SO KAOHSIUNG JOURNAL OF MEDICAL SCIENCES
LA English
DT Article
DE Adipokines; Bipolar disorder; Metabolic syndrome; Vaspin
ID OXIDATIVE STRESS; OBESITY; ADIPONECTIN; DYSFUNCTION; DEPRESSION;
   ADIPOKINES; LEPTIN; PREVALENCE; DISEASE
AB Metabolic disorders and abnormal levels of circulating adipokines have been reported in patients with bipolar disorder (BD). The aim of this study was to investigate the differences in the correlations of vaspin plasma levels and metabolic parameters between two groups: patients with BD and mentally healthy persons. We measured plasma levels of vaspin, metabolic parameters, and metabolic syndrome (MS) in 101 patients with BD and 90 healthy control (HC) subjects. Patients with BD were evaluated with the Young Mania Rating Scale (YMRS) to assess manic symptoms and the Hamilton Depression Scale (HDS) to assess depressive symptoms. The Global Assessment of Functioning (GAF) was used to evaluate the general functions of the patients. Body mass index (BMI), weight, waist circumference (WC), fasting glucose, and triglyceride levels of the study group were statistically higher than those of the healthy controls (p = 0.001, p < 0.001, p < 0.001, p = 0.027, and p = 0.001 respectively). Plasma levels of vaspin were 0.978 ng/ml in patients with BD and 0.292 in the HC group (p < 0.001). Our study revealed associations between metabolic parameters/metabolic syndrome and vaspin plasma concentrations in patients with BD. Vaspin can play a specific role in the pathogenesis of metabolic disorders in these subjects and can be a specific indicator substance in BD. Copyright (C) 2018, Kaohsiung Medical University. Published by Elsevier Taiwan LLC.
C1 [Ertekin, Hulya; Sahin, Basak] Canakkale Onsekiz Mart Univ, Dept Psychiat, Canakkale, Turkey.
   [Caliskan, Ali Metehan; Inanli, Ikbal] Hlth Sci Univ, Dept Psychiat, Konya, Turkey.
   [Ertekin, Yusuf Haydar] Canakkale Onsekiz Mart Univ, Dept Family Med, Canakkale, Turkey.
C3 Canakkale Onsekiz Mart University; University of Health Sciences Turkey;
   Canakkale Onsekiz Mart University
RP Ertekin, H (corresponding author), Canakkale Onsekiz Mart Univ, Sch Med, Dept Psychiat, Fifth Floor, TR-17020 Canakkale, Turkey.
EM md.ertekin@comu.edu.tr
RI Inanli, Ikbal/D-1046-2017; Ertekin, yusuf/V-7149-2017; Caliskan,
   Ali/AAR-2993-2020; sahin, basak/A-5798-2017
OI Caliskan, Ali Metehan/0000-0002-7347-7200; Sahin,
   Basak/0000-0002-5943-4087
FU Canakkale Onsekiz Mart University Scientific Research and Projects
   Coordination Unit [TSA-2015-561]
FX This study was financed by Canakkale Onsekiz Mart University Scientific
   Research and Projects Coordination Unit (Contract No: TSA-2015-561).
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NR 32
TC 4
Z9 4
U1 1
U2 4
PU ELSEVIER TAIWAN
PI TAIPEI
PA RM N-412, 4F, CHIA HSIN BUILDING 11, NO 96, ZHONG SHAN N ROAD SEC 2,
   TAIPEI, 10449, TAIWAN
SN 1607-551X
J9 KAOHSIUNG J MED SCI
JI Kaohsiung J. Med. Sci.
PD SEP
PY 2018
VL 34
IS 9
BP 522
EP 528
DI 10.1016/j.kjms.2018.04.003
PG 7
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA GS1MY
UT WOS:000443292200006
PM 30173782
OA gold
DA 2025-06-11
ER

PT J
AU Ioakeim-Skoufa, I
   Poblador-Plou, B
   Carmona-Pírez, J
   Díez-Manglano, J
   Navickas, R
   Gimeno-Feliu, LA
   González-Rubio, F
   Jureviciene, E
   Dambrauskas, L
   Prados-Torres, A
   Gimeno-Miguel, A
AF Ioakeim-Skoufa, Ignatios
   Poblador-Plou, Beatriz
   Carmona-Pirez, Jonas
   Diez-Manglano, Jesus
   Navickas, Rokas
   Andres Gimeno-Feliu, Luis
   Gonzalez-Rubio, Francisca
   Jureviciene, Elena
   Dambrauskas, Laimis
   Prados-Torres, Alexandra
   Gimeno-Miguel, Antonio
TI Multimorbidity Patterns in the General Population: Results from the
   EpiChron Cohort Study
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Article
DE age; chronic diseases; factor analysis; multimorbidity; patterns;
   real-world data; sex; Spain
ID NATIONAL EPIDEMIOLOGIC SURVEY; METABOLIC SYNDROME; CHRONIC DISEASES;
   SUBSTANCE USE; USE DISORDER; DEPRESSION; COMORBIDITY; PREVALENCE;
   ANXIETY; CARE
AB The correct management of patients with multimorbidity remains one of the main challenges for healthcare systems worldwide. In this study, we analyze the existence of multimorbidity patterns in the general population based on gender and age. We conducted a cross-sectional study of individuals of all ages from the EpiChron Cohort, Spain (1,253,292 subjects), and analyzed the presence of systematic associations among chronic disease diagnoses using exploratory factor analysis. We identified and clinically described a total of 14 different multimorbidity patterns (12 in women and 12 in men), with some relevant differences in the functions of age and gender. The number and complexity of the patterns was shown to increase with age in both genders. We identified associations of circulatory diseases with respiratory disorders, chronic musculoskeletal diseases with depression and anxiety, and a very consistent pattern of conditions whose co-occurrence is known as metabolic syndrome (hypertension, diabetes, obesity, and dyslipidaemia), among others. Our results demonstrate the potential of using real-world data to conduct large-scale epidemiological studies to assess the complex interactions among chronic conditions. This could be useful in designing clinical interventions for patients with multimorbidity, as well as recommendations for healthcare professionals on how to handle these types of patients in clinical practice.
C1 [Ioakeim-Skoufa, Ignatios] IIS Aragon, EpiChron Res Grp, Zaragoza 50009, Spain.
   [Poblador-Plou, Beatriz; Carmona-Pirez, Jonas; Diez-Manglano, Jesus; Andres Gimeno-Feliu, Luis; Gonzalez-Rubio, Francisca; Prados-Torres, Alexandra; Gimeno-Miguel, Antonio] Miguel Servet Univ Hosp, Aragon Hlth Sci Inst IACS, IIS Aragon, EpiChron Res Grp, Zaragoza 50009, Spain.
   [Poblador-Plou, Beatriz; Andres Gimeno-Feliu, Luis; Gonzalez-Rubio, Francisca; Prados-Torres, Alexandra; Gimeno-Miguel, Antonio] ISCIII, Hlth Serv Res Chron Patients Network REDISSEC, Madrid 28222, Spain.
   [Carmona-Pirez, Jonas; Gonzalez-Rubio, Francisca] Delicias Primary Care Hlth Ctr, Aragon Hlth Serv SALUD, Zaragoza 50003, Spain.
   [Diez-Manglano, Jesus] Royo Villanova Hosp, Aragon Hlth Serv SALUD, Internal Med Serv, Zaragoza 50015, Spain.
   [Navickas, Rokas; Jureviciene, Elena; Dambrauskas, Laimis] Vilnius Univ, Fac Med, LT-03101 Vilnius, Lithuania.
   [Navickas, Rokas; Jureviciene, Elena; Dambrauskas, Laimis] Vilnius Univ Hosp, Dept Biomed Res, Santaros Klin, LT-08661 Vilnius, Lithuania.
   [Andres Gimeno-Feliu, Luis] San Pablo Primary Care Hlth Ctr, Aragon Hlth Serv SALUD, Zaragoza 50003, Spain.
   [Andres Gimeno-Feliu, Luis] Univ Zaragoza, Dept Med, Zaragoza 50009, Spain.
   [Gonzalez-Rubio, Francisca] Grp Trabajo Utilizac Farmacos SemFYC, Madrid 28004, Spain.
C3 Miguel Servet University Hospital; Instituto de Salud Carlos III;
   Vilnius University; Vilnius University Hospital Santariskiu Klinikos;
   University of Zaragoza
RP Gimeno-Miguel, A (corresponding author), Miguel Servet Univ Hosp, Aragon Hlth Sci Inst IACS, IIS Aragon, EpiChron Res Grp, Zaragoza 50009, Spain.
EM ignacio.ioakim@hotmail.es; bpoblador.iacs@aragon.es;
   jcarmona@iisaragon.es; jdiez@aragon.es; rokas.navickas@santa.lt;
   lugifel@gmail.com; franciscagonzalezrubio@gmail.com;
   Elena.Jureviciene@santa.lt; Laimis.Dambrauskas@santa.lt;
   sprados.iacs@aragon.es
RI Gonzalez Rubio, Francisca/GPT-3556-2022; Gimeno-Miguel,
   Antonio/AAC-9611-2019; Jureviciene, Elena/CAA-7509-2022; Carmona Pirez,
   Jonas/AAE-8594-2022; Poblador-Plou, Beatriz/ABC-7915-2020;
   Díez-Manglano, J/AAC-3198-2020; Ioakeim-Skoufa, Ignatios/AAX-4807-2020;
   Gimeno Feliu, Luis Andres/E-5390-2016; Navickas, Rokas/U-4843-2017;
   Prados-Torres, Alexandra/P-5818-2017
OI Gimeno Feliu, Luis Andres/0000-0003-2928-6623; Navickas,
   Rokas/0000-0002-8258-8009; Prados-Torres, Alexandra/0000-0002-5704-6056;
   Gonzalez Rubio, Francisca/0000-0001-5939-4436; Gimeno-Miguel,
   Antonio/0000-0002-5440-1710; Poblador-Plou, Beatriz/0000-0002-5119-5093;
   Jureviciene, Elena/0000-0003-4331-5179; Diez-Manglano,
   Jesus/0000-0002-3132-2171; Ioakeim-Skoufa, Ignatios/0000-0002-6518-749X;
   Carmona-Pirez, Jonas/0000-0002-6268-8803
FU Gobierno de Aragon; European Regional Development Fund "Construyendo
   Europa desde Aragon" [B01_20R]; Instituto de Salud Carlos III; IIS
   Aragon [CM19/00164]; Health Programme 2014-2020 of the European Union
FX This research was funded by Gobierno de Aragon and the European Regional
   Development Fund "Construyendo Europa desde Aragon", grant number
   B01_20R. Dr. J.C.-P. was awarded a Rio Hortega research grant from
   Instituto de Salud Carlos III and IIS Aragon (grant number CM19/00164).
   The study was conducted in the context of Joint Action CHRODIS-PLUS
   funded by the Health Programme 2014-2020 of the European Union, as a
   collaboration between WP6 members. Sole responsibility lies with the
   authors, and the Consumers, Health, Agriculture and Food Executive
   Agency is not responsible for any use that may be made of the
   information contained therein.
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NR 64
TC 41
Z9 42
U1 0
U2 19
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD JUN
PY 2020
VL 17
IS 12
AR 4242
DI 10.3390/ijerph17124242
PG 15
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA ML6LO
UT WOS:000549575300001
PM 32545876
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Batacan, RB
   Duncan, MJ
   Dalbo, VJ
   Connolly, KJ
   Fenning, AS
AF Batacan, Romeo B., Jr.
   Duncan, Mitch J.
   Dalbo, Vincent J.
   Connolly, Kylie J.
   Fenning, Andrew S.
TI Light-intensity and high-intensity interval training improve
   cardiometabolic health in rats
SO APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
LA English
DT Article
DE physical activity; sedentary behaviour; oxidative stress; inflammation;
   cardiovascular; metabolism
ID CONTINUOUS MODERATE EXERCISE; PHYSICAL-ACTIVITY; CARDIOVASCULAR EVENTS;
   INTERMITTENT EXERCISE; SEDENTARY BEHAVIOR; METABOLIC SYNDROME; OXIDATIVE
   STRESS; BLOOD-PRESSURE; NITRIC-OXIDE; HEART-RATE
AB Physical activity has the potential to reduce cardiometabolic risk factors but evaluation of different intensities of physical activity and the mechanisms behind their health effects still need to be fully established. This study examined the effects of sedentary behaviour, light-intensity training, and high-intensity interval training on biometric indices, glucose and lipid metabolism, inflammatory and oxidative stress markers, and vascular and cardiac function in adult rats. Rats (12 weeks old) were randomly assigned to 1 of 4 groups: control (CTL; no exercise), sedentary (SED; no exercise and housed in small cages to reduce activity), light-intensity trained (LIT; four 30-min exercise bouts/day at 8 m/min separated by 2-h rest period, 5 days/week), and high-intensity interval trained (HIIT, four 2.5-min work bouts/day at 50 m/min separated by 3-min rest periods, 5 days/week). After 12 weeks of intervention, SED had greater visceral fat accumulation (p < 0.01) and slower cardiac conduction (p = 0.04) compared with the CTL group. LIT and HIIT demonstrated beneficial changes in body weight, visceral and epididymal fat weight, glucose regulation, low-density lipoprotein cholesterol, total cholesterol, and mesenteric vessel contractile response compared with the CTL group (p < 0.05). LIT had significant improvements in insulin sensitivity and cardiac conduction compared with the CTL and SED groups whilst HIIT had significant improvements in systolic blood pressure and endothelium-independent vasodilation to aorta and mesenteric artery compared with the CTL group (p < 0.05). LIT and HIIT induce health benefits by improving traditional cardiometabolic risk factors. LIT improves cardiac health while HIIT promotes improvements in vascular health.
C1 [Batacan, Romeo B., Jr.; Dalbo, Vincent J.; Connolly, Kylie J.; Fenning, Andrew S.] Cent Queensland Univ, Sch Med & Appl Sci, Rockhampton, Qld 4702, Australia.
   [Batacan, Romeo B., Jr.; Fenning, Andrew S.] Cent Queensland Univ, Ctr Phys Act Studies, Rockhampton, Qld 4702, Australia.
   [Duncan, Mitch J.] Univ Newcastle, Sch Med & Publ Hlth, Prior Res Ctr Phys Act & Nutr, Fac Hlth & Med, Univ Dr, Callaghan, NSW 2308, Australia.
   [Dalbo, Vincent J.] Cent Queensland Univ, Clin Biochem Lab, Rockhampton, Qld 4702, Australia.
C3 Central Queensland University; Central Queensland University; University
   of Newcastle; Central Queensland University
RP Batacan, RB (corresponding author), Cent Queensland Univ, Sch Med & Appl Sci, Rockhampton, Qld 4702, Australia.; Batacan, RB (corresponding author), Cent Queensland Univ, Ctr Phys Act Studies, Rockhampton, Qld 4702, Australia.
EM r.j.batacan@cqu.edu.au
RI Duncan, Mitch/V-1708-2019
OI Duncan, Mitch/0000-0002-9166-6195; BATACAN, ROMEO JR/0000-0002-6084-7452
FU Central Queensland University; CQUniversity Health Collaborative
   Research Network (CRN); Future Leader Fellowship from the National Heart
   Foundation of Australia [100029]
FX The authors thank Geraldine Buitrago, Candice Pullen, and Douglas
   Jackson for their assistance during the terminal experiments, and Dr.
   Jeff Coombes for allowing R.B.B. to work in his laboratory for the
   F2-isoprostane analysis. R.B.B. is supported by the Strategic Research
   Scholarship grant from Central Queensland University. This manuscript is
   in part supported by CQUniversity Health Collaborative Research Network
   (CRN). M.J.D. is supported by a Future Leader Fellowship (ID 100029)
   from the National Heart Foundation of Australia.
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NR 63
TC 16
Z9 21
U1 0
U2 29
PU CANADIAN SCIENCE PUBLISHING
PI OTTAWA
PA 65 AURIGA DR, SUITE 203, OTTAWA, ON K2E 7W6, CANADA
SN 1715-5312
EI 1715-5320
J9 APPL PHYSIOL NUTR ME
JI Appl. Physiol. Nutr. Metab.
PD SEP
PY 2016
VL 41
IS 9
BP 945
EP 952
DI 10.1139/apnm-2016-0037
PG 8
WC Nutrition & Dietetics; Physiology; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics; Physiology; Sport Sciences
GA DU6BC
UT WOS:000382296800006
PM 27523646
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Kazukauskiene, N
   Podlipskyte, A
   Varoneckas, G
   Mickuviene, N
AF Kazukauskiene, Nijole
   Podlipskyte, Aurelija
   Varoneckas, Giedrius
   Mickuviene, Narseta
TI Insulin Resistance in Association with Thyroid Function, Psychoemotional
   State, and Cardiovascular Risk Factors
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Article
DE insulin resistance; coronary artery disease; thyroid function;
   psychoemotional
ID BODY-MASS INDEX; METABOLIC SYNDROME; HOSPITAL ANXIETY; HORMONE LEVELS;
   DEPRESSION; HEART; PREVALENCE
AB Background: Individuals with insulin resistance (IR) have a high risk of diabetes or metabolic syndrome, and they are more likely to have depression. Furthermore, IR by itself is a major cardiovascular risk factor in healthy persons. Thus, we aimed to investigate IR in association with thyroid function, psychoemotional state, and cardiovascular risk factors among 45-84-year-old citizens of Palanga. Methods: A randomized epidemiological study was performed with 850 subjects. All participants were evaluated for sociodemographic, clinical, and cardiovascular risk factors and biochemical analysis. IR was evaluated by the homeostasis model assessment of IR (HOMA-IR). Results: All study participants were stratified into groups without IR (HOMA-IR <= 2.7) and with IR (HOMA-IR > 2.7). The analysis of parameters between the two study groups showed some statistically significant relationships between IR and cardiovascular risk factors. The predictable accuracy was presented using receiver performance characteristic curves for HOMA-IR scores in women and men separately. If the HOMA-IR score is higher than 3.45, individuals are significantly more likely to have type 2 diabetes mellitus (T2DM). Conclusions: An increase of fasting glucose and more frequent incidence of metabolic syndrome, diabetes, and cardiovascular diseases in subjects with IR are associated with the prevalence of cardiovascular risk factors. There was no significant association between thyroid function and HOMA-IR. HOMA-IR cut-offs could predict the presence of T2DM.
C1 [Kazukauskiene, Nijole; Podlipskyte, Aurelija; Varoneckas, Giedrius; Mickuviene, Narseta] Lithuanian Univ Hlth Sci, Neurosci Inst, Lab Behav Med, LT-00135 Palanga, Lithuania.
C3 Lithuanian University of Health Sciences
RP Kazukauskiene, N (corresponding author), Lithuanian Univ Hlth Sci, Neurosci Inst, Lab Behav Med, LT-00135 Palanga, Lithuania.
EM nijole.kazukauskiene@lsmuni.lt; aurelija.podlipskyte@lsmuni.lt;
   giedrius.varoneckas@lsmuni.lt; narseta.mickuviene@lsmuni.lt
OI Kazukauskiene, Nijole/0000-0003-4268-5303; Varoneckas,
   Giedrius/0000-0001-8073-4335; Podlipskyte, Aurelija/0000-0003-1412-6168
FU Research Council of Lithuania [S-SEN-20-13]
FX This research was funded by a grant (No. S-SEN-20-13) from the Research
   Council of Lithuania.
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NR 63
TC 3
Z9 3
U1 0
U2 6
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD APR
PY 2021
VL 18
IS 7
AR 3388
DI 10.3390/ijerph18073388
PG 14
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA RK9BI
UT WOS:000638581900001
PM 33805872
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Abou Kassm, S
   Rico, MS
   Naja, W
   Alvarado, JM
   Halaby, A
   Limosin, F
   Hoertel, N
AF Abou Kassm, Sandra
   Rico, Marina Sanchez
   Naja, Wadih
   Alvarado, Jesus M.
   Halaby, Athar
   Limosin, Frederic
   Hoertel, Nicolas
CA CSA Study Grp
TI Metabolic syndrome and risk of death in older adults with major
   psychiatric disorders: Results from a 5-year prospective multicenter
   study
SO INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
LA English
DT Article
DE bipolar disorder; cardiovascular; major depressive disorder; metabolic
   syndrome; mortality; older; psychiatric disorders; schizophrenia
ID MENTAL-HEALTH-CARE; DEPRESSIVE SYMPTOMS; MORTALITY; OBESITY
AB Objectives: No study has explored the association of individual components of metabolic syndrome with mortality in older patients with psychiatric disorders. In this report, we examined whether metabolic syndrome or any of its components predicted mortality in a cohort of older adults with psychiatric disorders.
   Methods: We used data from a multicenter 5-year prospective cohort, including 634 in- and out-patients with schizophrenia, bipolar or major depressive disorder. Metabolic syndrome was assessed at baseline following NCEP-ATPIII criteria. Cause of death was categorized as cardiovascular disorder (CVD) mortality, non-CVD disease-related mortality (e.g., infections), suicide and accident.
   Results: 122 participants (44.0%) were diagnosed with metabolic syndrome at baseline. In the full sample, there was no significant association between metabolic syndrome or any of its components with all-cause, CVD and non-CVD mortality. However, for the subpopulation of older adults with major depressive disorder, metabolic syndrome was significantly associated with increased all-cause and disease-related mortality after adjustment for age, sex and smoking status (p = 0.032 and p = 0.036, respectively). There was a significant interaction between metabolic syndrome and psychiatric diagnoses indicating that in participants with major depressive disorder, metabolic syndrome had a significantly greater effect on all-cause mortality (p = 0.025) and on disease-related mortality (p = 0.008) than in participants with either bipolar disorder or schizophrenia.
   Conclusions: Our findings do not support an association between metabolic syndrome and increased mortality in older patients with major psychiatric disorders. Several explanations are discussed, including a survival bias, a lack of sensitivity of the used cut-offs and a ceiling effect of metabolic syndrome on mortality in this very high-risk population. The latter hypothesis could also explain the significant association between metabolic syndrome and mortality in the depressive subgroup, where a ceiling effect is yet to be reached, given the less marked premature mortality in depressive patients compared to those with bipolar disorder or schizophrenia.
C1 [Abou Kassm, Sandra; Naja, Wadih; Halaby, Athar] Lebanese Univ, Fac Med Sci, Dept Psychiat, Beirut, Lebanon.
   [Abou Kassm, Sandra] Ctr Hosp Guillaume Regnier, Dept Psychiat, Rennes, France.
   [Rico, Marina Sanchez; Limosin, Frederic; Hoertel, Nicolas] Western Paris Univ Hosp, AP HP, Dept Psychiat, Issy Les Moulineaux, France.
   [Rico, Marina Sanchez; Alvarado, Jesus M.] Univ Complutense Madrid, Fac Psychol, Dept Psychobiol & Behav Sci Methods, Pozuelo De Alarcon, Spain.
   [Limosin, Frederic; Hoertel, Nicolas] Psychiat & Neurosci Ctr, INSERM 1266, Paris, France.
   [Limosin, Frederic; Hoertel, Nicolas] Univ Paris, Paris, France.
C3 Lebanese University; Assistance Publique Hopitaux Paris (APHP);
   Universite Paris Cite; Hopital Universitaire Corentin-Celton - APHP;
   Complutense University of Madrid; Institut National de la Sante et de la
   Recherche Medicale (Inserm); Universite Paris Cite; Universite Paris
   Cite
RP Abou Kassm, S (corresponding author), Lebanese Univ, Fac Med Sci, Dept Psychiat, Beirut, Lebanon.
EM sandra_akassm@hotmail.com
RI SR, M/HNC-4259-2023; Alvarado, Jesus/K-7296-2017; Abou Kassm,
   Sandra/AAU-5478-2021; Hoertel, Nicolas/H-9457-2015
OI Hoertel, Nicolas/0000-0002-7890-1349
FU Ministere des Affaires Sociales et de la Sante; French Psychiatric
   Congress
FX Ministere des Affaires Sociales et de la Sante; French Psychiatric
   Congress
CR Abou Kassm S, 2021, INT J GERIATR PSYCH, V36, P1204, DOI 10.1002/gps.5512
   Abou Kassm S, 2019, PSYCHIAT RES, V275, P238, DOI 10.1016/j.psychres.2019.03.036
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   Hoerte N, 2021, SOC PSYCH PSYCH EPID, V56, P1411, DOI 10.1007/s00127-020-01880-2
   Hoertel N, 2020, EUR ARCH PSY CLIN N, V270, P673, DOI 10.1007/s00406-019-01026-9
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   Ju SY, 2017, MEDICINE, V96, DOI 10.1097/MD.0000000000008491
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   Rethorst CD, 2017, PSYCHOL MED, V47, P2414, DOI 10.1017/S0033291717000897
   Schuster JP, 2020, INT PSYCHOGERIATR, V32, P441, DOI 10.1017/S1041610219000358
   Thomas F, 2011, J HYPERTENS, V29, P663, DOI 10.1097/HJH.0b013e32834320dc
   Vaccarino V, 2008, PSYCHOSOM MED, V70, P40, DOI 10.1097/PSY.0b013e31815c1b85
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NR 37
TC 1
Z9 1
U1 0
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0885-6230
EI 1099-1166
J9 INT J GERIATR PSYCH
JI Int. J. Geriatr. Psychiatr.
PD DEC
PY 2022
VL 37
IS 12
DI 10.1002/gps.5835
PG 13
WC Geriatrics & Gerontology; Gerontology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Psychiatry
GA 8S2VA
UT WOS:000928440500001
PM 36326073
DA 2025-06-11
ER

PT J
AU Cook, S
   Hugli, O
   Egli, M
   Vollenweider, P
   Burcelin, R
   Nicod, P
   Thorens, B
   Scherrer, U
AF Cook, S
   Hugli, O
   Egli, M
   Vollenweider, P
   Burcelin, R
   Nicod, P
   Thorens, B
   Scherrer, U
TI Clustering of cardiovascular risk factors mimicking the human metabolic
   syndrome X in eNOS null mice
SO SWISS MEDICAL WEEKLY
LA English
DT Article
DE endothelial nitric oxide synthase; metabolic syndrome; arterial
   hypertension; insulin resistance; hyperlipidaemia; glucose intolerance
ID NITRIC-OXIDE SYNTHASE; INSULIN-RESISTANCE; ESSENTIAL-HYPERTENSION;
   OBESITY; GENE
AB Aims/hypothesis: The metabolic syndrome comprises a clustering of cardiovascular risk factors but the underlying mechanism is not known. Mice with targeted disruption of endothelial nitric oxide synthase (eNOS) are hypertensive and insulin resistant. We wondered, whether eNOS deficiency in mice is associated with a phenotype mimicking the human metabolic syndrome.
   Methods and Results. In addition to arterial pressure and insulin sensitivity (euglycaemic hyperinsulinaemic clamp), we measured the plasma concentration of leptin, insulin, cholesterol, triglycerides, free fatty acids, fibrinogen and uric acid in 10 to 12 week old eNOS(-/-) and wild type mice. We also assessed glucose tolerance under basal conditions and following a metabolic stress with a high fat diet. As expected eNOS(-/-) mice were hypertensive and insulin resistant, as evidenced by fasting hyperinsulinaemia and a roughly 30 percent lower steady state glucose infusion rate during the clamp. eNOS(-/-) mice had a 1.5 to 2-fold elevation of the cholesterol, triglyceride and free fatty acid plasma concentration. Even though body weight was comparable, the leptin plasma level was 30% higher in eNOS(-/-) than in wild type mice. Finally, uric acid and fibrinogen were elevated in the eNOS(-/-) mice. Whereas under basal conditions, glucose tolerance was comparable in knock out and control mice, on a high fat diet, knock out mice became significantly more glucose intolerant than control mice.
   Conclusions: A single gene defect, eNOS deficiency, causes a clustering of cardiovascular risk factors in young mice. We speculate that defective nitric oxide synthesis could trigger many of the abnormalities making up the metabolic syndrome in humans.
C1 CHU Vaudois, Dept Internal Med, CH-1011 Lausanne, Switzerland.
   CHU Vaudois, Botnar Ctr Clin Res, CH-1011 Lausanne, Switzerland.
   Univ Lausanne, Inst Pharmacol & Toxicol, CH-1005 Lausanne, Switzerland.
C3 University of Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV);
   University of Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV);
   University of Lausanne
RP Scherrer, U (corresponding author), CHU Vaudois, Dept Internal Med, CH-1011 Lausanne, Switzerland.
RI ; Vollenweider, Peter/Q-4603-2016
OI cook, stephane/0000-0003-1221-2978; Vollenweider,
   Peter/0000-0002-0765-896X; Hugli, Olivier/0000-0003-2312-1625
CR Cook S, 2002, FUND CLIN PHARMACOL, V16, P441, DOI 10.1046/j.1472-8206.2002.00130.x
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NR 13
TC 134
Z9 147
U1 0
U2 6
PU E M H SWISS MEDICAL PUBLISHERS LTD
PI BASEL
PA STEINENTORSTRASSE 13, CH-4-10 BASEL, SWITZERLAND
SN 1424-7860
J9 SWISS MED WKLY
JI Swiss Med. Wkly.
PD JUN 28
PY 2003
VL 133
IS 25-26
BP 360
EP 363
PG 4
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 723PJ
UT WOS:000185440500002
PM 12947532
DA 2025-06-11
ER

PT J
AU Beckie, TK
   Fletcher, GF
   Beckstead, JW
   Schocken, DD
   Evans, ME
AF Beckie, Theresa K.
   Fletcher, Gerald F.
   Beckstead, Jason W.
   Schocken, Douglas D.
   Evans, Mary E.
TI Adverse baseline physiological and psychosocial profiles of women
   enrolled in a cardiac rehabilitation clinical trial
SO JOURNAL OF CARDIOPULMONARY REHABILITATION AND PREVENTION
LA English
DT Article
DE cardiac rehabilitation; depression; psychosocial; risk factors; women
ID CORONARY-HEART-DISEASE; ACUTE MYOCARDIAL-INFARCTION; ARTERY-DISEASE;
   SECONDARY PREVENTION; PHYSICAL-ACTIVITY; DEPRESSIVE SYMPTOMS;
   GENDER-DIFFERENCES; METABOLIC SYNDROME; EXERCISE; ASSOCIATION
AB PURPOSE: Coronary heart disease (CHD) remains the leading cause of death in women. Despite positive outcomes associated with cardiac rehabilitation (CR), investigations of women are sparse. This article presents the baseline physiological and psychosocial profiles of 182 women in the Women's-Only Cardiac Rehabilitation study.
   METHOD: Women were randomized to a women's-only motivational interviewing or traditional CR group. Physiological measures included lipid profiles, body mass index, functional capacity, and anthropomorphic measures. Psychosocial measures included optimism, hope, social support, anxiety, depression, quality of life, and health perceptions. The median age was used to split the sample to examine data on 92 younger (<= 64 years) and 90 older >64 years) women.
   RESULTS: With a mean age of 63 years, 66.5% were white, 47% were retired, and 54% were married. Most women were physically inactive (83%), hypertensive (76%), and overweight (56%). Most women (71.4%) met the criteria for metabolic syndrome. Younger women demonstrated significantly worse psychosocial profiles than older women. More of the younger women (64%) had depressive symptoms than older women (37%). Younger women demonstrated a mean Center for Epidemiological Studies Depression Scale score of 20.8 +/- 12.4, whereas older women had a substantially lower mean score of 14.9 +/- 9.5 (P < .001). Younger participants also reported significantly more anxiety than older participants (38.8 +/- 13.4 vs 32.8 +/- 10.6, P <.001).
   CONCLUSION: Younger women enrolled in a CR clinical trial had adverse baseline risk factor profiles placing them at high risk for disease progression.
C1 [Beckie, Theresa K.; Beckstead, Jason W.; Schocken, Douglas D.; Evans, Mary E.] Univ S Florida, Coll Nursing, Tampa, FL 33612 USA.
   [Fletcher, Gerald F.] Coll Med, Mayo Clin, Jacksonville, FL USA.
C3 State University System of Florida; University of South Florida; Mayo
   Clinic
RP Beckie, TK (corresponding author), Univ S Florida, Coll Nursing, MDC Box 22,12901, Tampa, FL 33612 USA.
EM tbeckie@helth.usf.edu
RI Beckie, Theresa/R-4212-2019
FU NINR NIH HHS [R01 NR 07678] Funding Source: Medline
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NR 82
TC 18
Z9 23
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1932-7501
EI 1932-751X
J9 J CARDIOPULM REHABIL
JI J. Cardiopulm. Rehabil. Prev.
PD JAN-FEB
PY 2008
VL 28
IS 1
BP 52
EP 60
PG 9
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Cardiovascular System & Cardiology
GA 257FT
UT WOS:000252785300010
PM 18277832
DA 2025-06-11
ER

PT J
AU Velásquez, SC
   Vivares, LG
   Cardona-Arias, JA
AF Cardona Velasquez, Santiago
   Guzman Vivares, Laura
   Antonio Cardona-Arias, Jaiberth
TI Systematization of clinical trials related to treatment of metabolic
   syndrome, 1980-2015
SO ENDOCRINOLOGIA DIABETES Y NUTRICION
LA English
DT Article
DE Metabolic syndrome X; Clinical trials as topic; Literature review as
   topic
ID LIFE-STYLE INTERVENTION; INSULIN SENSITIVITY; RISK-FACTORS; PARALLEL;
   STRESS; CARE
AB Introduction: Despite the clinical, epidemiological, and economic significance of metabolic syndrome, the profile of clinical trials on this disease is unknown.
   Objective: To characterize the clinical trials related to treatment of metabolic syndrome during the 1980-2015 period.
   Methods: Systematic review of the literature using an ex ante search protocol which followed the phases of the guide Preferred Reporting Items for Systematic Reviews and Meta-Analyses in four multidisciplinary databases with seven search strategies. Reproducibility and methodological quality of the studies were assessed.
   Results: One hundred and six trials were included, most from the United States, Italy, and Spain, of which 63.2% evaluated interventions effective for several components of the syndrome such as diet (40.6%) or physical activity (22.6%). Other studies assessed drugs for a single factor such as hypertension (7.5%), hypertriglyceridemia (11.3%), or hyperglycemia (9.4%). Placebo was used as control in 54.7% of trials, and outcome measures included triglycerides (52.8%), HDL (48.1%), glucose (29.2%), BMI (33.0%), blood pressure (27.4%), waist circumference (26.4%), glycated hemoglobin (11.3%), and hip circumference (7.5%).
   Conclusion: It was shown that studies ob efficacy of treatment for metabolic syndrome are scarce and have mainly been conducted in the last five years and in high-income countries. Trials on interventions that affect three or more factors and assess several outcome measures are few, and lifestyle interventions (diet and physical activity) are highlighted as most important to impact on this multifactorial syndrome. (C) 2017 SEEN. Published by Elsevier Espana, S.L.U. All rights reserved.
C1 [Cardona Velasquez, Santiago; Guzman Vivares, Laura] Univ Antioquia, Escuela Microbiol, Grp Invest Salud & Sostenibilidad, Medellin, Colombia.
   [Antonio Cardona-Arias, Jaiberth] Univ Antioquia, Escuela Microbiol, Medellin, Colombia.
   [Antonio Cardona-Arias, Jaiberth] Univ Cooperat Colombia, Fac Med, Bogota, Colombia.
C3 Universidad de Antioquia; Universidad de Antioquia; Universidad
   Cooperativa de Colombia
RP Cardona-Arias, JA (corresponding author), Univ Antioquia, Escuela Microbiol, Medellin, Colombia.; Cardona-Arias, JA (corresponding author), Univ Cooperat Colombia, Fac Med, Bogota, Colombia.
EM jaiberthcardona@gmail.com
RI Cardona, Jaiberth/GZL-3892-2022
OI Cardona Arias, Jaiberth/0000-0002-7101-929X; Guzman-Vivares,
   Laura/0000-0002-8958-6575
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NR 39
TC 4
Z9 4
U1 0
U2 3
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2530-0180
J9 ENDOCRINOL DIAB NUTR
JI Endocrinol. Diabetes Nutr.
PD FEB
PY 2017
VL 64
IS 2
BP 82
EP 91
DI 10.1016/j.endien.2016.09.004
PG 10
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA EY2IS
UT WOS:000403792400004
PM 28440782
DA 2025-06-11
ER

PT J
AU Dou, XX
   Kim, Y
   Chu, H
AF Dou, Xiangxiang
   Kim, Yonghwan
   Chu, Hyunsik
TI Prevalence of Metabolic Syndrome According to Physical Activity, Dietary
   Habits, Mental Status, Social Status, Health Behavior, and Obesity
   Phenotypes in Korean Adolescents: 2016-2021
SO FOODS
LA English
DT Article
DE adolescent; metabolic syndrome; aerobic; breakfast; depression; stress;
   household income; dietary habits
ID BREAKFAST CONSUMPTION; RISK-FACTORS; ASSOCIATION; DEPRESSION;
   RESISTANCE; CHILDREN; ADULTS
AB Environmental factors play a role in increasing or decreasing the risk of metabolic syndrome (MetS) in adolescents. We analyzed the impact of physical activity (PA), dietary habits, and mental and socioeconomic status on MetS prevalence in 2143 (boys: 1113, girls: 1030, age: 13-18 years) Korean middle- and high-school students. Metabolically healthy obesity and metabolically unhealthy normal weight were also evaluated. MetS occurred in 215 participants (10.0%), and boys had a higher MetS rate than girls. There was no significant difference in alcohol consumption and smoking experience between individuals with and those without MetS. The odds ratio (OR) for high-school students was 1.33 (95%CI, 1.001-1.789, p = 0.043) times that of middle-school students. Depression, low aerobic PA, and high sedentary time increased the ORs to 1.64 (95%CI, 1.059-2.539, p = 0.020), 1.52 (95%CI, 1.092-2.203, p = 0.003), and 1.86 (95%CI, 1.342-2.587, p < 0.001), respectively. Higher energy intake and low weekly breakfast consumption frequency yielded ORs of 1.46 (95%CI, 1.046-2.555, p = 0.025) and 1.70 (95%CI, 1.244-2.339, p = 0.011), respectively. Strength training, stress, suicidal ideation, dining out frequency, and household income did not impact MetS prevalence. Despite obesity, MetS decreased by 29.7% with high aerobic PA and 37.9% with high weekly breakfast consumption frequency. In conclusion, MetS risk was higher for men, individuals with depression, and high-school students. Low aerobic activity, high calorie intake, and low weekly breakfast consumption frequency increased MetS risk. Despite obesity, high aerobic activity, low sedentary time, and breakfast consumption was associated with lower MetS risk.
C1 [Dou, Xiangxiang] Woosuk Univ, Dept Sports Welf Educ, Wonju 55338, South Korea.
   [Kim, Yonghwan] Gangneung Wonju Natl Univ, Dept Phys Educ, Kangnung 25457, South Korea.
   [Chu, Hyunsik] Gangneung Yeoungdong Univ, Dept Forest Leisure Sprots, Kangnung 25521, South Korea.
C3 Woosuk University; Gangneung-Wonju National University
RP Kim, Y (corresponding author), Gangneung Wonju Natl Univ, Dept Phys Educ, Kangnung 25457, South Korea.; Chu, H (corresponding author), Gangneung Yeoungdong Univ, Dept Forest Leisure Sprots, Kangnung 25521, South Korea.
EM douxiang@stu.woosuk.ac.kr; yhkim@gwnu.ac.kr; sik0070@gyu.ac.kr
OI kim, yong hwan/0000-0002-1327-8998
FU 2023 Academic Research Support Program in Gangneung-Wonju National
   University
FX This study was supported by the 2023 Academic Research Support Program
   in Gangneung-Wonju National University.
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TC 5
Z9 5
U1 4
U2 12
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2304-8158
J9 FOODS
JI Foods
PD SEP
PY 2023
VL 12
IS 17
AR 3304
DI 10.3390/foods12173304
PG 13
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA R6SL3
UT WOS:001065633400001
PM 37685235
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Sales, ARK
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AF Sales, Allan R. K.
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TI Aerobic exercise acutely prevents the endothelial dysfunction induced by
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SO AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
LA English
DT Article
DE flow-mediated dilation; shear rate; mental stress test; aerobic exercise
ID FLOW-MEDIATED DILATION; CORONARY-HEART-DISEASE; LOWER-LIMB EXERCISE;
   BRACHIAL-ARTERY; VASCULAR FUNCTION; BLOOD-FLOW; HUMANS; IMPACT;
   METAANALYSIS; DILATATION
AB Mental stress induces transient endothelial dysfunction, which is an important finding for subjects at cardiometabolic risk. Thus, we tested whether aerobic exercise prevents this dysfunction among subjects with metabolic syndrome (MetS) and whether an increase in shear rate during exercise plays a role in this phenomenon. Subjects with MetS participated in two protocols. In protocol 1 (n = 16), endothelial function was assessed using brachial artery flow-mediated dilation (FMD). Subjects then underwent a mental stress test followed by either 40 min of leg cycling or rest across two randomized sessions. FMD was assessed again at 30 and 60 min after exercise or rest, with a second mental stress test in between. Mental stress reduced FMD at 30 and 60 min after the rest session (baseline: 7.7 +/- 0.4%, 30 min: 5.4 +/- 0.5%, and 60 min: 3.9 +/- 0.5%, P < 0.05 vs. baseline), whereas exercise prevented this reduction (baseline: 7.5 +/- 0.4%, 30 min: 7.2 +/- 0.7%, and 60 min: 8.7 +/- 0.8%, P > 0.05 vs. baseline). Protocol 2 (n = 5) was similar to protocol 1 except that the first period of mental stress was followed by either exercise in which the brachial artery shear rate was attenuated via forearm cuff inflation or exercise without a cuff. Noncuffed exercise prevented the reduction in FMD (baseline: 7.5 +/- 0.7%, 30 min: 7.0 +/- 0.7%, and 60 min: 8.7 +/- 0.8%, P > 0.05 vs. baseline), whereas cuffed exercise failed to prevent this reduction (baseline: 7.5 +/- 0.6%, 30 min: 5.4 +/- 0.8%, and 60 min: 4.1 +/- 0.9%, P < 0.05 vs. baseline). In conclusion, exercise prevented mental stress-induced endothelial dysfunction among subjects with MetS, and an increase in shear rate during exercise mediated this effect.
C1 [Sales, Allan R. K.; Fernandes, Igor A.; Rocha, Natalia G.; Costa, Lucas S.; Rocha, Helena N. M.; Mattos, Joao D. M.; Vianna, Lauro C.; Nobrega, Antonio C. L.] Univ Fed Fluminense, Dept Physiol & Pharmacol, Lab Exercise Sci, BR-24210130 Niteroi, RJ, Brazil.
   [Silva, Bruno M.] Univ Fed Sao Paulo, Dept Physiol, Sect Exercise Physiol, Sao Paulo, Brazil.
C3 Universidade Federal Fluminense; Universidade Federal de Sao Paulo
   (UNIFESP)
RP Nobrega, ACL (corresponding author), Univ Fed Fluminense, Dept Physiol & Pharmacol, Lab Exercise Sci, Rua Prof Hernani Pires Melo 106,Sala 101, BR-24210130 Niteroi, RJ, Brazil.
EM anobrega@id.uff.br
RI Sales, Allan/ABA-8691-2021; Mattos, João/AAD-4650-2019; da Nobrega,
   Antonio/O-5107-2019; Fernandes, Igor Alexandre/G-9589-2012; Silva,
   Bruno/F-7781-2010; Rocha, Helena/B-9530-2018; Rocha, Natalia
   Galito/AAN-7903-2020; Vianna, Lauro/A-8188-2008
OI Fernandes, Igor Alexandre/0000-0002-0206-6316; Fernandes, Igor
   Alexandre/0000-0003-3873-2656; Silva, Bruno/0000-0003-0473-3706; Rocha,
   Helena/0000-0002-4741-7343; Mattos, Joao Dario/0000-0002-7377-9348;
   Rocha, Natalia Galito/0000-0002-1990-9834; Vianna,
   Lauro/0000-0002-5747-0295
FU Brazilian National Council of Scientific and Technological Development;
   Foundation of Research Support of Rio de Janeiro State; Coordination for
   the Improvement of Higher Education Personnel; Brazilian Funding Agency
   for Studies and Projects
FX This work was partially supported by research grants from the Brazilian
   National Council of Scientific and Technological Development, the
   Foundation of Research Support of Rio de Janeiro State, the Coordination
   for the Improvement of Higher Education Personnel, and the Brazilian
   Funding Agency for Studies and Projects.
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NR 37
TC 26
Z9 28
U1 1
U2 16
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0363-6135
EI 1522-1539
J9 AM J PHYSIOL-HEART C
JI Am. J. Physiol.-Heart Circul. Physiol.
PD APR
PY 2014
VL 306
IS 7
BP H963
EP H971
DI 10.1152/ajpheart.00811.2013
PG 9
WC Cardiac & Cardiovascular Systems; Physiology; Peripheral Vascular
   Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Physiology
GA AE6CV
UT WOS:000334077400004
PM 24531810
DA 2025-06-11
ER

PT J
AU Kim, MD
   Yang, HJ
   Kang, NR
   Park, JH
   Jung, YE
AF Kim, Moon-Doo
   Yang, Hyun-Ju
   Kang, Na Ri
   Park, Joon Hyuk
   Jung, Young-Eun
TI Association between subclinical hypothyroidism and metabolic syndrome
   among individuals with depression
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Depression; Subclinical hypothyroidism; Metabolic syndrome
ID THYROID-HORMONES; HEALTH
AB Background: Although the connection among low thyroid function, metabolic abnormalities, and depression is well documented, the relationship between subclinical hypothyroidism (SCH) and metabolic syndrome (MetS) in depression remains unclear. This study examined the association between SCH and MetS in a large sample with depression.
   Methods: The study analyzed 370 individuals with depression who participated in the 2014 Korea National Health and Nutrition Examination Survey. Associations between the presence of SCH and MetS were estimated after adjusting for related factors using multivariate logistic regression analysis.
   Results: In the 370 individuals with depression, the prevalence of SCH was 9.4% (SE = 1.6%). The prevalence of MetS was significantly higher in depressed individuals with than in those without SCH (56.3 +/- 9.5% vs. 22.8 +/- 2.6%; p = 0.001). After adjusting for covariates, the odds of having MetS were 7.127 times greater among depressed individuals with SCH than among those without SCH (95% confidence interval, 2.077-24.458).
   Limitations: The cross-sectional study design prevented inferences regarding causality and the effects of changes in variables.
   Conclusions: Depressed individuals with SCH are more likely to meet the criteria for MetS. These results highlight the significance of low thyroid function and the metabolic burden of individuals with depression.
C1 [Kim, Moon-Doo; Yang, Hyun-Ju; Kang, Na Ri; Park, Joon Hyuk; Jung, Young-Eun] Jeju Natl Univ, Sch Med, Dept Psychiat, Jeju, South Korea.
C3 Jeju National University
RP Jung, YE (corresponding author), Jeju Natl Univ, Sch Med, Dept Psychiat, Jeju, South Korea.
EM jyejye77@daum.net
RI Kang, Nari/JXL-3029-2024
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NR 20
TC 22
Z9 22
U1 0
U2 9
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29a, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD MAR 1
PY 2020
VL 264
BP 494
EP 497
DI 10.1016/j.jad.2019.11.080
PG 4
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA KH1BD
UT WOS:000510380300064
PM 31759661
DA 2025-06-11
ER

PT J
AU Chee, GL
   Wynaden, D
   Heslop, K
AF Chee, Gin-Liang
   Wynaden, Dianne
   Heslop, Karen
TI Improving metabolic monitoring rate for young people aged 35 and younger
   taking antipsychotic medications to treat a psychosis: A literature
   review
SO ARCHIVES OF PSYCHIATRIC NURSING
LA English
DT Review
DE Metabolic screening; Metabolic syndrome; Antipsychotics; Young people;
   Mental health nursing
ID MAJOR DEPRESSIVE DISORDER; MENTAL-DISORDERS; PHYSICAL HEALTH;
   DIABETES-MELLITUS; BIPOLAR DISORDER; OF-ONSET; INTERVENTION; YOUTH;
   RISK; SCHIZOPHRENIA
AB Young people aged 35 and younger who are taking antipsychotic medications to treat a psychosis are a high risk for developing metabolic syndrome due to the adverse effects of the medications. This paper reports the finding of a review of literature to identify interventions to improve metabolic monitoring rates in this group. A review of 478 studies identified 15 articles which met the inclusion criteria. Five articles reported single-intervention studies and the remaining integrated two or more interventions to improve uptake level of metabolic monitoring. As metabolic syndrome can be detected early through metabolic monitoring in young people taking antipsychotics, early intervention is important to improve their physical health trajectory.
C1 [Chee, Gin-Liang; Wynaden, Dianne; Heslop, Karen] Curtin Univ, Sch Nursing Midwifery & Paramed, Perth, WA, Australia.
   [Chee, Gin-Liang] POB 480, Fremantle, WA 6959, Australia.
C3 Curtin University
RP Chee, GL (corresponding author), 1 Alma St, Fremantle, WA, Australia.; Chee, GL (corresponding author), POB 480, Fremantle, WA 6959, Australia.
EM Johnathan.Chee@health.wa.gov.au
RI Heslop, Karen/AFM-4040-2022
OI Wynaden, Dianne/0000-0002-3985-7621; Heslop, Karen/0000-0002-1136-3718
CR Amer Diabet Assoc, 2004, DIABETES CARE, V27, P596, DOI 10.2337/diacare.27.2.596
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NR 51
TC 8
Z9 12
U1 0
U2 3
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0883-9417
EI 1532-8228
J9 ARCH PSYCHIAT NURS
JI Arch. Psychiatr. Nurs.
PD DEC
PY 2017
VL 31
IS 6
BP 624
EP 633
DI 10.1016/j.apnu.2017.09.002
PG 10
WC Nursing; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Psychiatry
GA FP3XJ
UT WOS:000417551000016
PM 29179831
DA 2025-06-11
ER

PT J
AU Takahashi, A
   Hayashi, F
   Ohira, T
   Shimabukuro, M
   Sakai, A
   Maeda, M
   Hosoya, M
   Kazama, JJ
   Hashimoto, K
   Sato, S
   Nakano, H
   Nagao, M
   Okazaki, K
   Ohto, H
   Yasumura, S
   Ohira, H
AF Takahashi, Atsushi
   Hayashi, Fumikazu
   Ohira, Tetsuya
   Shimabukuro, Michio
   Sakai, Akira
   Maeda, Masaharu
   Hosoya, Mitsuaki
   Kazama, Junichiro J.
   Hashimoto, Koichi
   Sato, Shiho
   Nakano, Hironori
   Nagao, Masanori
   Okazaki, Kanako
   Ohto, Hitoshi
   Yasumura, Seiji
   Ohira, Hiromasa
TI Impact of Changes in Lifestyle and Psychological Factors on the
   Incidence of Metabolic Syndrome after the Great East Japan Earthquake:
   Follow-up of the Fukushima Health Management Survey
SO JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
LA English
DT Article
DE Metabolic syndrome; Lifestyle; Great East Japan Earthquake
ID MENTAL-HEALTH; RISK; METAANALYSIS; ASSOCIATION; EVACUATION; SMOKING;
   WEIGHT
AB Aim: The Fukushima Daiichi Nuclear Power Plant accident caused lifestyle changes and psychological distress in residents living near the plant. This study clarified the associations between changes in residents' lifestyles and psychological factors with the onset of metabolic syndrome (METs) after the accident. Methods: This longitudinal study included 10,373 residents who underwent the Comprehensive Health Check and Mental Health and Lifestyle Survey in Fiscal Year (FY) 2013. Follow-up surveys were conducted between FY 2014 and FY 2017. Lifestyle changes and the METs incidence were evaluated using a logistic regression model. Results: METs developed in 14.0% of subjects. In addition to metabolic factors, such as the body mass index, hypertension, dyslipidemia, and diabetes mellitus, there were differences in physical activity, fast walking, eating fast, eating habits before bedtime, skipping breakfast, current smoking, and alcohol intake between subjects with and without new-onset METs. Eating fast, current smoking, and drinking alcohol were positively associated with new-onset METs, whereas starting physical activity and fast walking were inversely associated with new-onset METs. Conclusions: Disaster-related lifestyle changes, such as eating fast, starting to smoke, and continued alcohol intake, were risk factors for new-onset METs after the Fukushima Daiichi Nuclear Power Plant accident.
C1 [Takahashi, Atsushi; Ohira, Hiromasa] Fukushima Med Univ, Sch Med, Dept Gastroenterol, 1-Hikarigaoka, Fukushima, Fukushima 9601295, Japan.
   [Takahashi, Atsushi; Hayashi, Fumikazu; Ohira, Tetsuya; Shimabukuro, Michio; Sakai, Akira; Maeda, Masaharu; Hosoya, Mitsuaki; Kazama, Junichiro J.; Hashimoto, Koichi; Sato, Shiho; Nakano, Hironori; Nagao, Masanori; Okazaki, Kanako; Ohto, Hitoshi; Yasumura, Seiji] Fukushima Med Univ, Radiat Med Sci Ctr Fukushima Hlth Management Surve, Sch Med, Fukushima, Japan.
   [Hayashi, Fumikazu; Ohira, Tetsuya; Sato, Shiho; Nakano, Hironori; Nagao, Masanori] Fukushima Med Univ, Sch Med, Dept Epidemiol, Fukushima, Japan.
   [Shimabukuro, Michio] Fukushima Med Univ, Sch Med, Dept Diabetol & Endocrinol, Fukushima, Japan.
   [Sakai, Akira] Fukushima Med Univ, Sch Med, Dept Radiat Life Sci, Fukushima, Japan.
   [Maeda, Masaharu] Fukushima Med Univ, Sch Med, Dept Disaster Psychiat, Fukushima, Japan.
   [Hosoya, Mitsuaki; Hashimoto, Koichi] Fukushima Med Univ, Sch Med, Dept Pediat, Fukushima, Japan.
   [Kazama, Junichiro J.] Fukushima Med Univ, Sch Med, Dept Nephrol & Hypertens, Fukushima, Japan.
   [Okazaki, Kanako] Fukushima Med Univ, Sch Med, Dept Phys Therapy, Fukushima, Japan.
   [Yasumura, Seiji] Fukushima Med Univ, Sch Med, Dept Publ Hlth, Fukushima, Japan.
C3 Fukushima Medical University; Fukushima Medical University; Fukushima
   Medical University; Fukushima Medical University; Fukushima Medical
   University; Fukushima Medical University; Fukushima Medical University;
   Fukushima Medical University; Fukushima Medical University; Fukushima
   Medical University
RP Takahashi, A (corresponding author), Fukushima Med Univ, Sch Med, Dept Gastroenterol, 1-Hikarigaoka, Fukushima, Fukushima 9601295, Japan.
EM junior@fmu.ac.jp
RI SATO, SHIHO/MEE-4755-2025; Sakai, Akira/IWM-1983-2023
FX Acknowledgements The authors thank the staff of the Fukushima Health
   Management Survey for their cooperation. The findings and conclusions of
   this article are solely the responsibility of the authors and do not
   represent the official views of the Fukushima Prefectural Government.
   All the authors participated in the conception and design of the study.
   A. Takahashi, T. Ohira, F. Hayashi, and S. Sato performed statistical
   analysis of the data and wrote the manuscript. All authors participated
   in the interpretation of the results and drafting of the manuscript, and
   approved the final version.
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NR 25
TC 1
Z9 1
U1 1
U2 1
PU JAPAN ATHEROSCLEROSIS SOC
PI TOKYO
PA NICHINAI-KAIKAN B1, 3-28-8 HONGO BUNKYO-KU, TOKYO, 113-0033, JAPAN
SN 1340-3478
EI 1880-3873
J9 J ATHEROSCLER THROMB
JI J. Atheroscler. Thromb.
PY 2025
VL 32
IS 3
BP 345
EP 355
DI 10.5551/jat.64923
EA SEP 2024
PG 11
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA Z1U3A
UT WOS:001312561900001
PM 39261024
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Armutcu, F
   Ataymen, M
   Atmaca, H
   Gurel, A
AF Armutcu, Ferah
   Ataymen, Meryem
   Atmaca, Hulusi
   Gurel, Ahmet
TI Oxidative stress markers, C-reactive protein and heat shock protein 70
   levels in subjects with metabolic syndrome
SO CLINICAL CHEMISTRY AND LABORATORY MEDICINE
LA English
DT Article
DE carbonyl protein; C-reactive protein; heat shock protein 70; metabolic
   syndrome; oxidative stress
ID XANTHINE-OXIDASE ACTIVITY; HEAT-SHOCK PROTEINS; URIC-ACID;
   INSULIN-RESISTANCE; DIABETIC-PATIENTS; CARBONYL CONTENT; EXPRESSION;
   HSP70; RISK; ATHEROSCLEROSIS
AB Background: The metabolic syndrome is a cluster of cardiovascular risk factors and essential components of metabolic syndrome are hyperglycemia, hypertension, visceral obesity, hypertriglyceridemia and low high-density lipoprotein cholesterol. Oxidative stress plays a critical role in the pathogenesis of metabolic syndrome components and insulin resistance. The aim of this study was to investigate the role of oxidative stress, C-reactive protein and heat shock protein 70 levels in the pathogenesis of this disease.
   Methods: A total of 36 patients diagnosed with metabolic syndrome and 33 controls were included in the study. Malondialdehyde, carbonyl protein, C-reactive protein and heat shock protein 70 levels and xanthine oxidase and superoxide dismutase activities were measured in the serum of the subjects.
   Results: Mean serum malondialdehyde, carbonyl protein, C-reactive protein (p < 0.01, p < 0.05 and p < 0.001, respectively) and xanthine oxidase activity were significantly higher (p < 0.01) in serum of the patients than the control group. Superoxide dismutase activity and heat shock protein 70 levels were significantly lower (p < 0.01 and p < 0.05, respectively) in serum of the patients.
   Conclusions: These results suggest that oxidative stress parameters and components of metabolic syndrome are closely related; therefore, significant alterations may occur in the antioxidant and inflammatory status. However, further studies are required to evaluate the possible molecular mechanisms of heat shock protein 70 levels in metabolic syndrome.
C1 [Armutcu, Ferah] Canakkale Onsekiz Mart Univ, Fac Med, Dept Biochem, TR-17100 Canakkale, Turkey.
   [Ataymen, Meryem; Gurel, Ahmet] Karaelmas Univ, Fac Med, Dept Biochem, Zonguldak, Turkey.
   [Atmaca, Hulusi] Karaelmas Univ, Fac Med, Dept Endocrinol, Zonguldak, Turkey.
C3 Canakkale Onsekiz Mart University; Zonguldak Bulent Ecevit University;
   Zonguldak Bulent Ecevit University
RP Armutcu, F (corresponding author), Canakkale Onsekiz Mart Univ, Fac Med, Dept Biochem, TR-17100 Canakkale, Turkey.
EM drferah@yahoo.com
RI Armutcu, Ferah/A-1364-2019
OI Atmaca, Mehmet Hulusi/0009-0009-0158-7804
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NR 47
TC 80
Z9 88
U1 0
U2 19
PU WALTER DE GRUYTER GMBH
PI BERLIN
PA GENTHINER STRASSE 13, D-10785 BERLIN, GERMANY
SN 1434-6621
EI 1437-4331
J9 CLIN CHEM LAB MED
JI Clin. Chem. Lab. Med.
PY 2008
VL 46
IS 6
BP 785
EP 790
DI 10.1515/CCLM.2008.166
PG 6
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA 324TR
UT WOS:000257542800006
PM 18601599
DA 2025-06-11
ER

PT J
AU Lin, X
   Wang, QY
   Sun, SG
   Xu, GL
   Wu, Q
   Qi, MM
   Bai, F
   Yu, J
AF Lin, Xin
   Wang, Qiongying
   Sun, Shougang
   Xu, Guangli
   Wu, Qiang
   Qi, Miaomiao
   Bai, Feng
   Yu, Jing
TI Astragaloside IV promotes the eNOS/NO/cGMP pathway and improves left
   ventricular diastolic function in rats with metabolic syndrome
SO JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
LA English
DT Article
DE Astragaloside IV; metabolic syndrome; left ventricular diastolic
   dysfunction; endothelial nitric oxide synthase; oxidative stress; cyclic
   guanosine monophosphate (GMP)
ID NITRIC-OXIDE SYNTHASE; OXIDATIVE STRESS; SUPEROXIDE-DISMUTASE; INSULIN
   SENSITIVITY; CARDIOVASCULAR RISK; HEART-FAILURE; FRUCTOSE; ENDOTHELIUM;
   DYSFUNCTION; OBESITY
AB Objectives: This study aimed to explore the effects of astragaloside IV on metabolic syndrome induced by a high-fructose/high-fat diet in rats.
   Methods: Rats were randomized into four groups: normal control, metabolic syndrome, metabolic syndrome+intraperitoneal astragaloside 0.5 mg/kg/day, and metabolic syndrome+intraperitoneal astragaloside 2.0 mg/kg/day (n = 30 per group) for 14 continuous days. Left ventricular functions were evaluated by hemodynamic and echocardiographic parameters.
   Results: Metabolic syndrome rats had a thicker interventricular septum and left ventricular posterior wall, accompanied by a higher E/A wave ratio, reduced E' wave, increased A' wave, decreased E'/A' wave ratio, and higher E/E' wave ratio. Astragaloside decreased insulin and triglyceride levels and improved diastolic dysfunction with no effects on systolic function. A high-fructose/high-fat diet also increased oxidative stress and decreased the myocardial endothelial nitric oxide synthase (NOS) dimer ratio, thus impairing nitric oxide (NO) production and reducing cyclic guanosine monophosphate (cGMP) production. Astragaloside increased NO and cGMP production in the myocardium and improved diastolic function.
   Conclusions: Astragaloside alleviated oxidative stress and restored NO signaling, thus improving myocardial left ventricular diastolic dysfunction in rats with metabolic syndrome. The underlying mechanisms could be associated with alleviation of oxidative stress and activation of the endothelial NOS/NO/cGMP pathway.
C1 [Lin, Xin; Wang, Qiongying; Sun, Shougang; Xu, Guangli; Wu, Qiang; Qi, Miaomiao; Bai, Feng; Yu, Jing] Lanzhou Univ, Hosp 1, Dept Cardiol, 82 Chengguan Dist, Lanzhou 730030, Gansu, Peoples R China.
C3 Lanzhou University
RP Yu, J (corresponding author), Lanzhou Univ, Hosp 1, Dept Cardiol, 82 Chengguan Dist, Lanzhou 730030, Gansu, Peoples R China.
EM yujing2304@126.com
RI Bai, Feng/A-6778-2019; wu, qiong/GRY-4672-2022
FU Health Commission of Gansu Province Foundation [GZK-2018-51,
   GSWSKY2018-19]; Foundation of Lanzhou University Second Hospital
   [ynbskyjj2015-1-11, ynbskyjj2016-2-1, sdkyjj2016-10]; Cuiying Scientific
   and Technological Innovation Program of Lanzhou University Second
   Hospital [CY2017-MS14]; Cuiying Graduate Supervisor Applicant Training
   Program of Lanzhou University Second Hospital
FX This study was supported by the Health Commission of Gansu Province
   Foundation (GZK-2018-51and GSWSKY2018-19), the Foundation of Lanzhou
   University Second Hospital (ynbskyjj2015-1-11, ynbskyjj2016-2-1, and
   sdkyjj2016-10), the Cuiying Scientific and Technological Innovation
   Program of Lanzhou University Second Hospital (CY2017-MS14), and the
   Cuiying Graduate Supervisor Applicant Training Program of Lanzhou
   University Second Hospital.
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NR 46
TC 19
Z9 22
U1 0
U2 11
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0300-0605
EI 1473-2300
J9 J INT MED RES
JI J. Int. Med. Res.
PD JAN
PY 2020
VL 48
IS 1
AR 0300060519826848
DI 10.1177/0300060519826848
PG 15
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA KY5UM
UT WOS:000522638400017
PM 30843445
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Javed, A
   Afzal, M
AF Javed, Afzal
   Afzal, Maryam
TI Metabolic syndrome: Relevance to psychiatry
SO PAKISTAN JOURNAL OF MEDICAL SCIENCES
LA English
DT Review
DE mental disorders; metabolic syndrome; antipsychotic drugs; lifestyle
   management
ID IMPAIRED FASTING GLUCOSE; DIABETES-MELLITUS; EXCESS MORTALITY; PHYSICAL
   HEALTH; WEIGHT-GAIN; ANTIPSYCHOTIC MEDICATION; ATYPICAL ANTIPSYCHOTICS;
   CARDIOVASCULAR RISK; SCHIZOPHRENIA; PEOPLE
AB The treatment of mental illnesses is receiving considerable attention in the current medical literature and has been a focus of reviews for adapting a holistic approach for recognition and management of the physical health needs of these patients. Metabolic syndrome, a major public health problem linked to cardiovascular and other morbidities, has gained a significant importance in clinical settings and patients with severe mental illnesses who are at higher risk for different components of this syndrome due to their illness and its treatment require careful and regular monitoring in this regard. This article summarises the current thinking about the concept, nature and extent of this syndrome with special reference to mental health and discusses its relevance in the current management of these disorders.
C1 [Javed, Afzal] Univ Warwick, Warwick Med Sch, Hlth Sci Res Inst, Coventry CV4 7AL, W Midlands, England.
   [Afzal, Maryam] St Johns Hosp Livingstone, Fdn Year, Livingston, Scotland.
C3 University of Warwick
RP Javed, A (corresponding author), Med Ctr, 2 Manor Court Ave, Nuneaton CV11 5HX, England.
EM afzal.javed@ntlworld.com
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NR 73
TC 1
Z9 1
U1 0
U2 7
PU PROFESSIONAL MEDICAL PUBLICATIONS
PI SADDAR
PA PANORAMA CENTRE, RM 522, 5TH FLOOR, BLDG 2, RAJA GHAZANFAR ALI RD, PO
   BOX 8766, SADDAR, KARACHI 00000, PAKISTAN
SN 1682-024X
J9 PAK J MED SCI
JI Pak. J. Med. Sci.
PD JAN-MAR
PY 2008
VL 24
IS 1
BP 181
EP 186
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 284GU
UT WOS:000254695700040
DA 2025-06-11
ER

PT J
AU Bortolasci, CC
   Vargas, HO
   Nunes, SOV
   de Melo, LGP
   de Castro, MRP
   Moreira, EG
   Dodd, S
   Barbosa, DS
   Berk, M
   Maes, M
AF Bortolasci, Chiara Cristina
   Vargas, Heber Odebrecht
   Vargas Nunes, Sandra Odebrecht
   Piccoli de Melo, Luiz Gustavo
   Pizzo de Castro, Marcia Regina
   Moreira, Estefania Gastaldello
   Dodd, Seetal
   Barbosa, Decio Sabbatini
   Berk, Michael
   Maes, Michael
TI Factors influencing insulin resistance in relation to atherogenicity in
   mood disorders, the metabolic syndrome and tobacco use disorder
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Depression; Bipolar disorder; Metabolic syndrome; Atherogenic;
   Inflammation; Oxidative stress
ID DENSITY-LIPOPROTEIN CHOLESTEROL; HOMEOSTASIS MODEL ASSESSMENT; TOTAL
   ANTIOXIDANT STATUS; PLASMA URIC-ACID; OXIDATIVE STRESS;
   CARDIOVASCULAR-DISEASE; CIGARETTE-SMOKING; MAJOR DEPRESSION;
   RISK-FACTORS; DOUBLE-BLIND
AB Objective: This study examines the effects of malondialdehyde (MDA) and uric acid on insulin resistance and atherogenicity in subjects with and without mood disorders, the metabolic syndrome (MetS) and tobacco use disorder (TUD).
   Methods: We included 314 subjects with depression and bipolar depression, with and without the MetS and TUD and computed insulin resistance using the updated homeostasis model assessment (HOMA2IR) and atherogenicity using the atherogenic index of plasma (All)), that is log10 (triglycerides/high density lipoprotein (HDL) cholesterol.
   Results: HOEV1A2IR is correlated with body mass index (BMI) and uric acid levels, but not with mood disorders and TUD, while the AlP is positively associated with BMI, mood disorders. TUD, uric acid, MDA and male sex. Uric acid is positively associated with insulin and triglycericles and negatively with HDL cholesterol. MDA is positively associated with triglycericle levels. Comorbid mood disorders and TUD further increase AlP but not insulin resistance. Glucose is positively associated with increasing age, male gender and BMI.
   Discussion: The results show that mood disorders, TUD and BMI together with elevated levels of uric acid and MDA independently contribute to increased atherogenic potential, while BMI and uric acid are risk factors for insulin resistance. The findings show that mood disorders and TUD are closely related to an increased atherogenic potential but not to insulin resistance or the MetS. Increased uric acid is a highly significant risk factor for insulin resistance and increased atherogenic potential. MDA, a marker of lipid peroxidation, further contributes to different aspects of the atherogenic potential. Mood disorders and TUD increase triglyceride levels, lower HDL cholesterol and are strongly associated with the atherogenic, but not insulin resistance, component of the MetS. (C.) 2015 Elsevier B.V. All rights reserved.
C1 [Bortolasci, Chiara Cristina; Barbosa, Decio Sabbatini; Maes, Michael] Univ Estadual Londrina, Hlth Sci Postgrad Program, Londrina, Parana, Brazil.
   [Bortolasci, Chiara Cristina; Dodd, Seetal; Berk, Michael; Maes, Michael] Deakin Univ, Barwon Hlth, Impact Strateg Res Ctr, Geelong, Vic 3220, Australia.
   [Vargas, Heber Odebrecht; Vargas Nunes, Sandra Odebrecht] Univ Estadual Londrina, Dept Psychiat, Londrina, Parana, Brazil.
   [Piccoli de Melo, Luiz Gustavo; Pizzo de Castro, Marcia Regina] Univ Estadual Londrina, Univ Hosp, Ctr Approach & Treatment Smokers, Londrina, Parana, Brazil.
   [Moreira, Estefania Gastaldello] Univ Estadual Londrina, Dept Physiol Sci, Londrina, Parana, Brazil.
   [Barbosa, Decio Sabbatini] Univ Estadual Londrina, Hlth Sci Ctr, Dept Pathol Clin Anal & Toxicol, Londrina, Parana, Brazil.
   [Dodd, Seetal; Berk, Michael] Univ Melbourne, Dept Psychiat, Parkville, Vic 3052, Australia.
   [Berk, Michael] Florey Inst Neurosci & Mental Hlth, Parkville, Vic, Australia.
   [Berk, Michael] Orygen, Natl Ctr Excellence Youth Mental Hlth, Parkville, Vic, Australia.
   [Maes, Michael] Chulalongkorn Univ, Dept Psychiat, Bangkok, Thailand.
C3 Universidade Estadual de Londrina; Barwon Health; Deakin University;
   Universidade Estadual de Londrina; Universidade Estadual de Londrina;
   Universidade Estadual de Londrina; Universidade Estadual de Londrina;
   University of Melbourne; Florey Institute of Neuroscience & Mental
   Health; Orygen, The National Centre of Excellence in Youth Mental
   Health; Chulalongkorn University
RP Maes, M (corresponding author), Deakin Univ, Sch Med, IMPACT Strateg Res Ctr, POB 281, Geelong, Vic 3220, Australia.
EM dr.michaelmaes@hotmail.com
RI Nunes, Sandra/B-4035-2019; Maes, Michael/B-8546-2011; Barbosa,
   Décio/AAE-6351-2019; de Melo, Luiz Gustavo Piccoli/C-2271-2018; Berk,
   Michael/AGH-9427-2022; Moreira, Estefania/AAC-5959-2019; Bortolasci,
   Chiara/C-7336-2016; Berk, Michael/M-7891-2013
OI Dodd, Seetal/0000-0002-7918-4636; Maes, Michael/0000-0002-2012-871X;
   Bortolasci, Chiara/0000-0002-0794-6363; Moreira,
   Estefania/0000-0001-8362-9557; Melo, Luiz Gustavo Piccoli
   de/0000-0002-1078-8044; Berk, Michael/0000-0002-5554-6946
FU CAPES foundation [BEX 12745/13-8]; NHMRC Senior Principal Research
   Fellowship [1059660]; CNPq-PVE fellowship; Health Sciences Graduate
   Program fellowship, State University of Londrina
FX CCB is supported by CAPES foundation, Scholarship BEX 12745/13-8.r MB is
   supported by a NHMRC Senior Principal Research Fellowship 1059660.r MM
   is supported by a CNPq-PVE fellowship and the Health Sciences Graduate
   Program fellowship, State University of Londrina.
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NR 62
TC 26
Z9 29
U1 1
U2 12
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD JUL 1
PY 2015
VL 179
BP 148
EP 155
DI 10.1016/j.jad.2015.03.041
PG 8
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA CI2VV
UT WOS:000354606500020
PM 25863911
DA 2025-06-11
ER

PT J
AU Happell, B
   Platania-Phung, C
   Scott, D
AF Happell, Brenda
   Platania-Phung, Chris
   Scott, David
TI Mental Health Nurse Incentive Program: Facilitating physical health care
   for people with mental illness?
SO INTERNATIONAL JOURNAL OF MENTAL HEALTH NURSING
LA English
DT Article
DE integrated care; mental health nurse; Mental Health Nurse Incentive
   Program; mental illness; physical health; primary care
ID METABOLIC SYNDROME; MEDICAL-CARE; SCHIZOPHRENIA; ATTITUDES; PERCEPTIONS;
   BARRIERS
AB People with serious mental illness have increased rates of physical ill-health and reduced contact with primary care services. In Australia, the Mental Health Nurse Incentive Program (MHNIP) was developed to facilitate access to mental health services. However, as a primary care service, the contribution to physical health care is worthy of consideration. Thirty-eight nurses who were part of the MHNIP participated in a national survey of nurses working in mental health about physical health care. The survey invited nurses to report their views on the physical health of consumers and the regularity of physical health care they provide. Physical health-care provision in collaboration with general practitioners (GPs) and other health-care professionals was reported as common. The findings suggest that the MHNIP provides integrated care, where nurses and GPs work in collaboration, allowing enough time to discuss physical health or share physical health activities. Consumers of this service appeared to have good access to physical and mental health services, and nurses had access to primary care professionals to discuss consumers' physical health and develop their clinical skills in the physical domain. The MHNIP has an important role in addressing physical health concerns, in addition to the mental health issues of people accessing this service.
C1 [Happell, Brenda] Cent Queensland Univ, Inst Hlth & Social Sci Res, Ctr Mental Hlth Nursing Innovat, Rockhampton, Qld 4702, Australia.
   [Happell, Brenda] Sch Nursing & Midwifery, Rockhampton, Qld 4702, Australia.
C3 Central Queensland University
RP Happell, B (corresponding author), Cent Queensland Univ, Inst Hlth & Social Sci Res, Ctr Mental Hlth Nursing Innovat, Rockhampton, Qld 4702, Australia.
EM b.happell@cqu.edu.au
RI Scott, David/AAE-5031-2021; Happell, Brenda/HSI-0570-2023
OI Happell, Brenda/0000-0002-7293-6583; Scott, David/0000-0001-5226-1972
FU Central Queensland University
FX The authors would like to thank the mental health nurses for their time
   and valuable input, and to the Australian College of Mental Health
   Nurses, particularly Kim Ryan and Haylie Maylia for their invaluable
   assistance in distributing the survey. The authors would also like to
   thank Christine Hanley for the online administration of the survey. The
   Research Advancement Award Scheme and Merit Grant Scheme of Central
   Queensland University provided the funding to make this study possible.
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NR 46
TC 23
Z9 23
U1 4
U2 69
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1445-8330
EI 1447-0349
J9 INT J MENT HEALTH NU
JI Int. J. Ment. Health Nurs.
PD OCT
PY 2013
VL 22
IS 5
BP 399
EP 408
DI 10.1111/inm.12006
PG 10
WC Nursing; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Psychiatry
GA 202IZ
UT WOS:000323209200005
PM 23279365
DA 2025-06-11
ER

PT J
AU Li, RC
   Zhang, LY
   Luo, H
   Lei, YL
   Zeng, L
   Zhu, JQ
   Tang, HR
AF Li, Rui-cen
   Zhang, Lingyun
   Luo, Han
   Lei, Yali
   Zeng, Li
   Zhu, Jingqiang
   Tang, Huairong
TI Subclinical hypothyroidism and anxiety may contribute to metabolic
   syndrome in Sichuan of China: a hospital-based population study
SO SCIENTIFIC REPORTS
LA English
DT Article
ID NUTRITION EXAMINATION SURVEY; 3RD NATIONAL-HEALTH; THYROID-DISORDERS;
   RISK-FACTORS; DEPRESSION; PREVALENCE; DEFINITION; INSTRUMENT; SEX
AB The prevalence of Metabolic syndrome (MetS) in Sichuan of China has not yet been estimated. Meanwhile the association among anxiety, subclinical hypothyroidism (SCH) and MetS was less well-studied. The data was retrieved retrospectively from Health Promotion Center of West China Hospital database between 2014 and 2017. Internal validation by randomizing into training and testing panel by 9:1 and external validation with National Health and Nutrition Examination Survey (NHNES) were conducted. 19006 subjects were included into analysis, and 3530 (18.6%) of them were diagnosed with MetS. In training panel, age, sex (male), SCH (presence), SAS score, alcohol (Sometimes & Usual) and smoking (Active) were identified as independent risk factors for MetS, which was confirmed in testing panel internally. NHNES data validated externally the association between free thyroxine (fT4) and MetS components. The C-indices of predicting MetS nomogram were 0.705 (95% CI: 0.696-0.714) and 0.728 (95% CI: 0.701-0.754) in training and testing panel respectively. In conclusion, MetS prevalence was 18.6% in Sichuan. SCH and anxiety may be associated with MetS independently. A risk scale-based nomogram with accurate and objective prediction ability was provided for check-up practice, but more cohort validation was needed.
C1 [Li, Rui-cen; Lei, Yali; Zeng, Li; Tang, Huairong] Sichuan Univ, West China Hosp, Hlth Promot Ctr, Chengdu, Peoples R China.
   [Zhang, Lingyun; Luo, Han; Zhu, Jingqiang] Sichuan Univ, West China Hosp, Thyroid & Parathyroid Surg, Chengdu, Peoples R China.
C3 Sichuan University; Sichuan University
RP Tang, HR (corresponding author), Sichuan Univ, West China Hosp, Hlth Promot Ctr, Chengdu, Peoples R China.; Zhu, JQ (corresponding author), Sichuan Univ, West China Hosp, Thyroid & Parathyroid Surg, Chengdu, Peoples R China.
EM zjq-wkys@163.com; HuairongTang@163.com
RI Zhang, Wei/AAG-9913-2019
FU Technology Research and Development Program of Sichuan Province, China
   [2018SZ0261]; National Key R&D Program of China [2017YFC907504]; China
   Postdoctoral Science Foundation [2019M653416]; Sichuan Province Science
   and Technology Project of China [2019YFS0333]
FX We appreciate Mrs. Lei's kind help for project coordinating. The project
   was founded by the Technology Research and Development Program of
   Sichuan Province, China (2018SZ0261); National Key R&D Program of China
   (2017YFC907504); China Postdoctoral Science Foundation (2019M653416);
   Sichuan Province Science and Technology Project of China (2019YFS0333).
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NR 42
TC 20
Z9 20
U1 0
U2 5
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD FEB 10
PY 2020
VL 10
IS 1
AR 2261
DI 10.1038/s41598-020-58973-w
PG 9
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Science & Technology - Other Topics
GA NB7LA
UT WOS:000560694800014
PM 32041973
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Peitl, MV
   Palaic, D
   Habibovic, F
   Seso, B
AF Peitl, Marija Vucic
   Palaic, Diana
   Habibovic, Fadil
   Seso, Bernard
TI THE INCIDENCE OF COMORBID MENTAL AND PHYSICAL CONDITIONS IN PATIENTS
   WITH POST-TRAUMATIC STRESS DISORDER
SO ACTA CLINICA CROATICA
LA English
DT Article
DE Post-traumatic stress disorder; Metabolic syndrome; Comorbidity;
   Hospitalization; Veterans
ID MAJOR DEPRESSIVE DISORDER; METABOLIC SYNDROME; VETERANS
AB There is a small body of research about mental and physical comorbidity in post-traumatic stress disorder (PTSD) patients despite the fact that some psychiatric disorders and physical conditions are commonly comorbid with PTSD. In this study, we researched the relationship between PTSD and its mental and physical comorbidities by comparing the number of patient hospitalizations across two ten-year periods. Our sample consisted of 2761 patients with warfare PTSD hospitalized during the 20-year period (1999-2018). The results confirmed a higher number of hospitalizations in the 2009-2018 period than in the 1999-2008 period for the group of PTSD patients with both mental and physical comorbidity. Furthermore, no significant difference was found in the number of hospitalizations between the two ten-year periods for the group of PTSD patients with mental comorbidity. We argued that both mental and physical comorbidities along with PTSD are needed to induce a significantly higher level of distress in patients, resulting in a higher number of hospitalizations after a longer period of time. Patients with the most severe conditions and comorbidity have a greater need to seek help from mental health professionals as their mental and physical state deteriorates to a higher degree when not in the treatment of any kind.
C1 [Peitl, Marija Vucic; Palaic, Diana; Habibovic, Fadil] Rijeka Univ Hosp Ctr, Dept Psychiat, Rijeka, Croatia.
   [Peitl, Marija Vucic] Univ Rijeka, Sch Med, Dept Psychiat & Psychol Med, Ul Brace Branchetta 20-1, HR-51000 Rijeka, Croatia.
   [Seso, Bernard] Soc Res & Support, Rijeka, Croatia.
C3 University of Rijeka; University of Rijeka
RP Peitl, MV (corresponding author), Univ Rijeka, Sch Med, Dept Psychiat & Psychol Med, Ul Brace Branchetta 20-1, HR-51000 Rijeka, Croatia.
EM marijavp@gmail.com
RI Habibović, Fadil/V-9028-2019
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NR 25
TC 3
Z9 3
U1 0
U2 2
PU SESTRE MILOSRDNICE UNIV HOSPITAL
PI ZAGREB
PA VINOGRADSKA C 29, ZAGREB, HR-10000, CROATIA
SN 0353-9466
EI 1333-9451
J9 ACTA CLIN CROAT
JI Acta Clin. Croat.
PD JUN
PY 2022
VL 61
IS 2
BP 295
EP 302
DI 10.20471/acc.2022.61.02.16
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 7I6SG
UT WOS:000904014500016
PM 36818934
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Sjogren, P
   Basu, S
   Rosell, M
   Silveira, A
   de Faire, U
   Vessby, B
   Hamsten, A
   Hellenius, ML
   Fisher, RM
AF Sjogren, P
   Basu, S
   Rosell, M
   Silveira, A
   de Faire, U
   Vessby, B
   Hamsten, A
   Hellenius, ML
   Fisher, RM
TI Measures of oxidized low-density lipoprotein and oxidative stress are
   not related and not elevated in otherwise healthy men with the metabolic
   syndrome
SO ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
LA English
DT Article
DE metabolic syndrome; oxLDL; isoprostanes; oxidative stress; diet
ID INSULIN-RESISTANCE; ENDOTHELIAL FUNCTION; FATTY-ACIDS; INFLAMMATION;
   ASSOCIATION; PLASMA; RISK; GLUCOSE; INDEX; LDL
AB Objective - The metabolic syndrome predisposes to the development of cardiovascular diseases. Oxidative stress and elevated circulating oxidized low-density lipoprotein (LDL) concentrations are related to cardiovascular disease and proposed to be features of the metabolic syndrome. F-2-isoprostanes are lipid peroxidation products and considered the most reliable biomarkers of oxidative stress.
   Methods and Results - Plasma oxidized LDL (oxLDL) and urinary 8-iso-prostaglandin F-2 alpha (8-iso-PGF(2 alpha); the major F-2-isoprostane) were analyzed in a cross-sectional study of 289 healthy men (62 to 64 years of age). Individuals completed a 7-day dietary record, and fasting plasma insulin, lipid, and lipoprotein concentrations, LDL particle size, and inflammatory markers were determined. National Cholesterol Education Program/Adult Treatment Panel III (NCEP/ATPIII) criteria were used to define the metabolic syndrome and individuals were grouped according to the number of risk factors for the metabolic syndrome (0, [n = 88; 30%]; >= 1, [n = 179; 62%], metabolic syndrome [n = 22; 8%]). Group comparisons revealed no differences for oxLDL, 8-iso-PGF(2 alpha), or reported intake of macronutrients, whereas C-reactive protein and interleukin-6 were increased in the metabolic syndrome. LDL cholesterol strongly determined oxLDL in univariate and multivariate analysis, but no relationship to 8-iso-PGF(2 alpha) was found. In turn, 8-iso-PGF(2 alpha) was related to reported intake of fat, fatty acids, and dietary antioxidants.
   Conclusions - There were no increases in plasma oxLDL or measures of oxidative stress (urinary 8-iso-PGF(2 alpha)) in these otherwise healthy 63-year-old men with the metabolic syndrome. Furthermore, no relationship between oxLDL and 8-iso-PGF(2 alpha) was found, but our results suggest a role for dietary factors in oxidative stress.
C1 Karolinska Inst, Dept Med, Atherosclerosis Res Unit, Stockholm, Sweden.
   Uppsala Univ, Dept Publ Hlth & Caring Sci, Uppsala, Sweden.
   Karolinska Inst, Inst Environm Med, Stockholm, Sweden.
   Karolinska Inst, Ctr Family & Community Med, Stockholm, Sweden.
C3 Karolinska Institutet; Uppsala University; Karolinska Institutet;
   Karolinska Institutet
RP Karolonska Univ Hosp, King Gustaf V Res Inst, Atherosclerosis Res Unit, S-17176 Stockholm, Sweden.
EM per.sjogren@ki.se
RI Fisher, Rachel/LRB-9254-2024; Sjogren, Per/N-5923-2014
OI Fisher, Rachel/0000-0002-6031-5288; Sjogren, Per/0000-0003-1824-3193;
   Silveira, Angela/0000-0003-2063-4935
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NR 43
TC 75
Z9 80
U1 0
U2 7
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1079-5642
EI 1524-4636
J9 ARTERIOSCL THROM VAS
JI Arterioscler. Thromb. Vasc. Biol.
PD DEC
PY 2005
VL 25
IS 12
BP 2580
EP 2586
DI 10.1161/01.ATV.0000190675.08857.3d
PG 7
WC Hematology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Hematology; Cardiovascular System & Cardiology
GA 986PF
UT WOS:000233461500025
PM 16224051
DA 2025-06-11
ER

PT J
AU Oberlin, LE
   Manuck, SB
   Gianaros, PJ
   Ferrell, RE
   Muldoon, MF
   Jennings, JR
   Flory, JD
   Erickson, KI
AF Oberlin, Lauren E.
   Manuck, Stephen B.
   Gianaros, Peter J.
   Ferrell, Robert E.
   Muldoon, Matthew F.
   Jennings, J. Richard
   Flory, Janine D.
   Erickson, Kirk I.
TI Blood Pressure Interacts With APOE ε4 to Predict Memory
   Performance in a Midlife Sample
SO NEUROPSYCHOLOGY
LA English
DT Article
DE cognition; blood pressure; Apolipoprotein epsilon 4; memory
ID APOLIPOPROTEIN-E EPSILON-4; CARDIOVASCULAR RISK-FACTORS; COGNITIVE
   DECLINE; ALZHEIMERS-DISEASE; EPISODIC MEMORY; METABOLIC SYNDROME;
   EXECUTIVE FUNCTION; PHYSICAL-ACTIVITY; WORKING-MEMORY; BRAIN ATROPHY
AB Objective: Elevated blood pressure and the Apolipoprotein epsilon 4 allele ( APOE epsilon 4) are independent risk factors for Alzheimer's disease. We sought to determine whether the combined presence of the APOE epsilon 4 allele and elevated blood pressure is associated with lower cognitive performance in cognitively healthy middle-aged adults. Methods: A total of 975 participants aged 30-54 (mean age = 44.47) were genotyped for APOE. Cardiometabolic risk factors including blood pressure, lipids, and glucose were assessed and cognitive function was measured using the Trail Making Test and the Visual Reproduction and Logical Memory subtests from the Wechsler Memory Scale. Results: Multivariable regression analysis showed that the association between APOE epsilon 4 and episodic memory performance varied as a function of systolic blood pressure (SBP), such that elevated SBP was predictive of poorer episodic memory performance only in APOE epsilon 4 carriers (beta = -.092; t = -2.614; p = .009). Notably, this association was apparent at prehypertensive levels (>= 130 mmHg), even after adjusting for physical activity, depression, smoking, and other cardiometabolic risk factors. Conclusions: The joint presence of APOE epsilon 4 and elevated SBP, even at prehypertensive levels, is associated with lower cognitive performance in healthy, middle-aged adults. Results of this study suggest that the combination of APOE epsilon 4and elevated SBP may synergistically compromise memory function well before the appearance of clinically significant impairments. Interventions targeting blood pressure control in APOE epsilon 4 carriers during midlife should be studied as a possible means to reduce the risk of cognitive decline in genetically susceptible samples.
C1 [Oberlin, Lauren E.; Manuck, Stephen B.; Gianaros, Peter J.; Ferrell, Robert E.; Erickson, Kirk I.] Univ Pittsburgh, Dept Psychol, Pittsburgh, PA 15260 USA.
   [Oberlin, Lauren E.; Gianaros, Peter J.; Erickson, Kirk I.] Univ Pittsburgh, Ctr Neural Basis Cognit, Pittsburgh, PA 15260 USA.
   [Ferrell, Robert E.] Univ Pittsburgh, Dept Human Genet, Pittsburgh, PA 15260 USA.
   [Muldoon, Matthew F.] Univ Pittsburgh, Sch Med, Inst Heart & Vasc, Pittsburgh, PA 15260 USA.
   [Jennings, J. Richard] Univ Pittsburgh, Dept Psychiat, Pittsburgh, PA 15260 USA.
   [Flory, Janine D.] Mt Sinai Sch Med, Dept Psychiat, New York, NY 10029 USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE); University
   of Pittsburgh; Pennsylvania Commonwealth System of Higher Education
   (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of
   Higher Education (PCSHE); University of Pittsburgh; Pennsylvania
   Commonwealth System of Higher Education (PCSHE); University of
   Pittsburgh; Pennsylvania Commonwealth System of Higher Education
   (PCSHE); University of Pittsburgh; Icahn School of Medicine at Mount
   Sinai
RP Oberlin, LE (corresponding author), Univ Pittsburgh, Dept Psychol, 210 S Bouquet St,3211 Sennott Sq, Pittsburgh, PA 15260 USA.
EM leo11@pitt.edu
RI Oberlin, Lauren/JUU-7342-2023; Erickson, Kirk/F-9997-2016
OI Erickson, Kirk/0000-0001-8736-981X; Oberlin, Lauren/0000-0001-9553-8070
FU National Institutes of Health [HL040962, DK095172]
FX This research was supported by National Institutes of Health Grants
   HL040962 to Stephen B. Manuck and DK095172 to Kirk I. Erickson.
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NR 81
TC 13
Z9 20
U1 0
U2 13
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 0894-4105
EI 1931-1559
J9 NEUROPSYCHOLOGY
JI Neuropsychology
PD SEP
PY 2015
VL 29
IS 5
BP 693
EP 702
DI 10.1037/neu0000177
PG 10
WC Psychology, Clinical; Neurosciences; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Neurosciences & Neurology
GA CQ1UR
UT WOS:000360385900004
PM 25730733
OA Green Accepted, hybrid
DA 2025-06-11
ER

PT J
AU Chau, JPC
   Leung, LYL
   Liu, X
   Lo, SHS
   Choi, KC
   Zhao, J
   Chiang, HCY
AF Chau, Janita Pak Chun
   Leung, Leona Yuen Ling
   Liu, Xu
   Lo, Suzanne Hoi Shan
   Choi, Kai Chow
   Zhao, Jie
   Chiang, Helen Chung Yan
TI Effects of Tai Chi on health outcomes among community-dwelling adults
   with or at risk of metabolic syndrome: A systematic review
SO COMPLEMENTARY THERAPIES IN CLINICAL PRACTICE
LA English
DT Review
DE Hypertension; Metabolic syndrome; Obesity; Physical exercise; Tai chi;
   Type 2 diabetes mellitus
ID CARDIOVASCULAR-DISEASE RISK; QUALITY-OF-LIFE; PROVISIONAL REPORT;
   OLDER-ADULTS; EXERCISE; DEFINITION; PREVALENCE; GLUCOSE; INTERVENTIONS;
   HYPERTENSION
AB Objectives: This systematic review evaluated the effects of Tai Chi on health outcomes among communitydwelling adults with or at risk of metabolic syndrome (MetS). Methods: Randomized controlled trials (RCTs) were searched in 10 databases. Data were statistically pooled for meta-analysis. Results: Twenty RCTs were included. One study involved adults with MetS, and the other 19 studies involved adults with at least one risk factor for MetS. Tai Chi was found to reduce waist circumference and increase highdensity lipoprotein cholesterol in obese adults. Tai Chi also reduces waist circumference, body mass index, blood glucose level, insulin resistance, and increases the quality of life (QoL) in adults with elevated blood glucose/type 2 diabetes (T2DM). Among participants with hypertension, Tai Chi improves blood pressure, lipid profiles, anxiety, depression, and physical QoL. Conclusions: Tai Chi may be effective for enhancing the physiological and psychosocial wellbeing of communitydwelling adults at risk of MetS. Further RCTs are needed to examine its effects in adults with MetS and identify optimal regimes.
C1 [Chau, Janita Pak Chun; Leung, Leona Yuen Ling; Liu, Xu; Lo, Suzanne Hoi Shan; Choi, Kai Chow; Zhao, Jie; Chiang, Helen Chung Yan] Chinese Univ Hong Kong, Fac Med, Nethersole Sch Nursing, Hong Kong, Peoples R China.
C3 Chinese University of Hong Kong
RP Liu, X (corresponding author), Chinese Univ Hong Kong, Fac Med, Nethersole Sch Nursing, Hong Kong, Peoples R China.
EM monicaxuliu@163.com
RI Liu, Xu/GWV-0098-2022; Zhao, Jie/JNE-8350-2023; Leung,
   Leona/AHE-8456-2022; Choi, Kai/F-1398-2018; Chau, Pak Chun
   Janita/A-4571-2015; Lo, Suzanne Hoi Shan/O-6229-2015
OI Chau, Pak Chun Janita/0000-0002-3750-7396; Leung, Yuen
   Ling/0000-0003-2704-7805; Lo, Suzanne Hoi Shan/0000-0002-9970-0642; LIU,
   XU/0000-0003-3997-9781
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NR 65
TC 18
Z9 18
U1 4
U2 43
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1744-3881
EI 1873-6947
J9 COMPLEMENT THER CLIN
JI Complement. Ther. Clin. Pract.
PD AUG
PY 2021
VL 44
AR 101445
DI 10.1016/j.ctcp.2021.101445
EA JUL 2021
PG 12
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Integrative & Complementary Medicine
GA TU8YM
UT WOS:000681316500008
PM 34260997
DA 2025-06-11
ER

PT J
AU Sun, AC
   Liu, ZT
AF Sun, Aochuan
   Liu, Zhengtang
TI Association between relative grip strength and depression among US
   middle-aged and older adults: results from the NHANES database
SO FRONTIERS IN PUBLIC HEALTH
LA English
DT Article
DE relative grip strength; depression; L-shaped; cross-sectional study;
   muscle strength; NHANES
ID HANDGRIP STRENGTH; METABOLIC SYNDROME; MUSCLE STRENGTH; METAANALYSIS;
   NUTRITION; HEALTH; ONSET; PHQ-9; MOOD
AB Background: Mental health issues among middle-aged and older adults are gaining increasing attention. Recent studies have shown that relative grip strength is associated with cardiovascular diseases and various cancers, but its relationship with depression remains unclear. Methods: This cross-sectional study included data from adults aged 50 years and older from the 2011-2014 National Health and Nutrition Examination Survey. Relative grip strength is calculated by dividing the maximum absolute grip strength of both hands by BMI. The Patient Health Questionnaire (PHQ-9) was used to evaluate the depressive outcome. Multivariate logistic regression was performed to assess the association between relative grip strength and depression. Results: In this study, a total of 3,639 participants (>= 50 years) with a mean age of 64.3 +/- 9.3 years were enrolled, of whom 48.9% were male. Compared with individuals with lower relative handgrip strength in Q1 (<= 1.64 kg/BMI), the adjusted OR values for relative handgrip strength and depression in Q2 (1.64-2.17 kg/BMI), Q3 (2.17-2.84 kg/BMI), and Q4 (>= 2.84 kg/BMI) were 0.69 (95% CI: 0.51, 0.93, p = 0.016), 0.36 (95% CI: 0.24, 0.55, p < 0.001), and 0.32 (95% CI: 0.20, 0.51, p < 0.001), respectively. The relationship between relative grip strength and depression presented an L-shaped curve (nonlinear, p = 0.006), with an inflection point of roughly 2.98 kg/BMI. Among participants with relative grip strength < 2.98 kg/BMI, the OR of incident depression was 0.41 (95% CI: 0.30-0.55, p < 0.001). Conclusion: Our findings indicated that relative grip strength was inversely associated with incident depression and demonstrated an L-shaped relationship among U.S. middle-aged and older adults. Relative grip strength could be the indicator for future screening of mental health.
C1 [Sun, Aochuan; Liu, Zhengtang] China Acad Chinese Med Sci, Xiyuan Hosp, Dept Geriatr, Beijing, Peoples R China.
   [Sun, Aochuan] Beijing Univ Chinese Med, Grad Sch, Beijing, Peoples R China.
C3 Xiyuan Hospital, CACMS; China Academy of Chinese Medical Sciences;
   Beijing University of Chinese Medicine
RP Liu, ZT (corresponding author), China Acad Chinese Med Sci, Xiyuan Hosp, Dept Geriatr, Beijing, Peoples R China.
EM doctorzht@126.com
RI sun, aochuan/KRQ-2990-2024
FU CACMS Innovation Fund [CI2021A01412]; National key research and
   development program [2020YFC2006103]
FX The author(s) declare financial support was received for the research,
   authorship, and/or publication of this article. This work was supported
   by CACMS Innovation Fund (grant number CI2021A01412) and National key
   research and development program (grant number 2020YFC2006103).
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NR 48
TC 2
Z9 3
U1 2
U2 3
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 2296-2565
J9 FRONT PUBLIC HEALTH
JI Front. Public Health
PD JUL 29
PY 2024
VL 12
AR 1416804
DI 10.3389/fpubh.2024.1416804
PG 9
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA C4Y7L
UT WOS:001289439200001
PM 39135921
OA gold, Green Accepted
DA 2025-06-11
ER

PT J
AU Abbasifard, M
   Bazmandegan, G
   Ostadebrahimi, H
   Foroutanian, F
   Kamiab, Z
AF Abbasifard, Mitra
   Bazmandegan, Gholamreza
   Ostadebrahimi, Hamid
   Foroutanian, Fatemeh
   Kamiab, Zahra
TI Relationship between metabolic syndrome and depression: A study based on
   Rafsanjan Youth Cohort Study
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Depression; Metabolic syndrome; Obesity; Cohort; Youth; Prospective
   epidemiological research studies in; IrAN (PERSIAN)
ID CARDIOVASCULAR-DISEASE; PREVALENCE; IRAN; ASSOCIATION; ADOLESCENTS;
   MORBIDITY; MORTALITY; HEALTH; TRENDS; RISK
AB Background: Depressed people are susceptible to metabolic syndrome ression and metabolic syndrome in the Rafsanjan Youth Cohort Study in 2021. Methods: In this cross-sectional study, the data of 3005 young people aged 15-35 under the coverage of urban and rural health centers was investigated in the enrollment stage of the Rafsanjan Youth Cohort Study as a part of the prospective epidemiological research studies in IrAN (PERSIAN). Data was collected using face-to-face interview and electronic questionnaires of the Rafsanjan Youth Cohort Study. Results: Age of the youth was 25.78 +/- 6.06 years, 56 % (n = 1682) were female. The prevalence of metabolic syndrome (MetS) was 7.7 % (95 % CI: 6.8 %-8.8 %) and the prevalence of depression was 11.1 % (95 % CI: 10.0 %-12.3 %). Depression did not have a significant impact on the odds ratio of developing MetS in young people (P = 0.604). The odds ratio (OR) of MetS increases by 1.057 times with increasing age (95 % CI for OR: 1.020-1.094). This OR is also 1.715 times higher in married young people than in unmarried Youth (95 % CI for OR: 1.715-2.692) and 0.196 times lower in young people with medium and high MET index than in young people with low MET index (95 % CI for OR: 0.048-0.811). Limitations: Inability to determine a causal relationship between MetS and depression. Conclusion: Due to the growing trend of components of MetS among the young population, this issue needs to be addressed in future policies and planning for prevention and control as a health priority.
C1 [Abbasifard, Mitra] Rafsanjan Univ Med Sci, Noncommunicable Dis Res Ctr, Rafsanjan, Iran.
   [Abbasifard, Mitra] Rafsanjan Univ Med Sci, Ali Ibn Abi Talib Hosp, Sch Med, Dept Internal Med, Rafsanjan, Iran.
   [Bazmandegan, Gholamreza] Rafsanjan Univ Med Sci, Res Inst Basic Med Sci, Physiol Pharmacol Res Ctr, Rafsanjan, Iran.
   [Bazmandegan, Gholamreza] Rafsanjan Univ Med Sci, Sch Med, Dept Physiol & Pharmacol, Rafsanjan, Iran.
   [Ostadebrahimi, Hamid] Rafsanjan Univ Med Sci, Ali Ibn Abi Talib Hosp, Sch Med, Dept Pediat, Rafsanjan, Iran.
   [Foroutanian, Fatemeh] Rafsanjan Univ Med Sci, Rafsanjan, Iran.
   [Kamiab, Zahra] Rafsanjan Univ Med Sci, Social Determinants Hlth Res Ctr, Rafsanjan, Iran.
   [Kamiab, Zahra] Rafsanjan Univ Med Sci, Sch Med, Dept Community Med, Rafsanjan, Iran.
RP Kamiab, Z (corresponding author), Rafsanjan Univ Med Sci, Sch Med, Dept Community Med, Rafsanjan, Iran.
EM dr.kamiab89@gmail.com
RI Ostadebrahimi, Hamid/H-7714-2017; Abbasifard, mitra/I-1595-2017; Kamiab,
   Zahra/H-5396-2017
FU Iranian Ministry of Health and Medical Education [700/534]
FX The authors would like to thank the Iranian Ministry of Health and
   Medical Education has contributed to the funding used in the PERSIAN
   Cohort through Grant no. 700/534.
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NR 47
TC 1
Z9 1
U1 2
U2 4
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD SEP 15
PY 2024
VL 361
BP 139
EP 145
DI 10.1016/j.jad.2024.05.157
EA JUN 2024
PG 7
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA WL3I8
UT WOS:001254981000001
PM 38824964
DA 2025-06-11
ER

PT J
AU Tamayo, A
   Mujahid, MS
   Laraia, B
   Warton, EM
   Blanchard, SD
   Kelly, M
   Moffet, HH
   Adler, N
   Schillinger, D
   Karter, AJ
AF Tamayo, Aracely
   Mujahid, Mahasin S.
   Laraia, Barbara
   Warton, E. Margaret
   Blanchard, Samuel D.
   Kelly, Maggi
   Moffet, Howard H.
   Adler, Nancy
   Schillinger, Dean
   Karter, Andrew J.
TI Police-Recorded Crime and Perceived Stress among Patients with Type 2
   Diabetes: the Diabetes Study of Northern California (DISTANCE)
SO JOURNAL OF URBAN HEALTH-BULLETIN OF THE NEW YORK ACADEMY OF MEDICINE
LA English
DT Article
DE Neighborhood/place; Diabetes; Stress
ID CARDIOMETABOLIC RISK-FACTORS; POISSON REGRESSION APPROACH; OBJECTIVELY
   MEASURED CRIME; PHYSICAL-ACTIVITY; NEIGHBORHOOD DEPRIVATION;
   PSYCHOLOGICAL STRESS; MANAGED CARE; HEALTH; PERCEPTIONS; SAFETY
AB While stress has been linked to poor health outcomes, little is known about the impact of objective measures of neighborhood crime on stress in patients with chronic disease. Using the Kaiser Permanente Diabetes Study of Northern California (DISTANCE), we examined associations between police-recorded crime (2005-2007) and stress (Perceived Stress Scale-4) in four large Northern California cities (Oakland, Sacramento, San Francisco, and San Jose). We performed stratified analysis by gender and race/ethnicity using generalized linear regression models. In our study sample (n = 3188, mean age 59, range 30-77), 10 % reported high stress. In adjusted analyses, higher neighborhood all crimes rate was associated with modest increase in high stress for African-American (OR = 1.10; 95 % CI 1.02-1.22) and Latina women (OR = 1.36; 95 % CI 1.10-1.67) and property crime showed similar associations with stress for these groups of women. Visible crime was associated with stress only for Latina women (OR = 1.43; 95 % CI 1.14-1.78). We found no association between crime and stress among men or other racial/ethnic groups of women. High crime levels may disproportionately impact health among certain subpopulations. Studies using additional measures of stress are necessary to differentiate the health impact of crime-related stress from other forms of stressors among individuals living with diabetes.
C1 [Tamayo, Aracely; Mujahid, Mahasin S.] Univ Calif Berkeley, Sch Publ Hlth, Div Epidemiol, 101 Haviland Hall, Berkeley, CA 94720 USA.
   [Laraia, Barbara] Univ Calif Berkeley, Div Publ Hlth Nutr, Berkeley Sch Publ Hlth, 207B Univ Hall, Berkeley, CA 94720 USA.
   [Warton, E. Margaret; Moffet, Howard H.; Karter, Andrew J.] Kaiser Permanente Div Res, 2000 Broadway, Oakland, CA 94612 USA.
   [Blanchard, Samuel D.; Kelly, Maggi] Univ Calif Berkeley, Berkeley Dept Environm Sci Policy & Management, 130 Mulford Hall, Berkeley, CA 94720 USA.
   [Adler, Nancy] Univ Calif San Francisco, San Francisco Ctr Hlth & Community, 3333 Calif St Laurel Hts, San Francisco, CA 94118 USA.
   [Schillinger, Dean] Univ Calif San Francisco, San Francisco Gen Hosp, San Francisco Ctr Vulnerable Populat, 1001 Portero Ave,SFGH 10, San Francisco, CA 94110 USA.
C3 University of California System; University of California Berkeley;
   University of California System; University of California Berkeley;
   Kaiser Permanente; University of California System; University of
   California Berkeley; University of California System; University of
   California San Francisco; University of California System; University of
   California San Francisco; San Francisco General Hospital Medical Center
RP Mujahid, MS (corresponding author), Univ Calif Berkeley, Sch Publ Hlth, Div Epidemiol, 101 Haviland Hall, Berkeley, CA 94720 USA.
EM mmujahid@berkeley.edu
RI Laraia, Barbara/GXG-1829-2022; Tamayo, Aracely/KHU-2891-2024; Adler,
   Nancy/ABR-3334-2022
FU National Institute of Diabetes and Digestive and Kidney Diseases [R01
   DK065664-01-A1, R01 DK080744]; National Heart Lung and Blood Institute
   of the National Institutes of Health [K01 HL115494]
FX This study was supported by grants from the National Institute of
   Diabetes and Digestive and Kidney Diseases (R01 DK065664-01-A1 and R01
   DK080744). Dr. Mujahid is supported by the National Heart Lung and Blood
   Institute of the National Institutes of Health (K01 HL115494).
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TC 6
Z9 7
U1 1
U2 9
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1099-3460
EI 1468-2869
J9 J URBAN HEALTH
JI J. Urban Health
PD OCT
PY 2016
VL 93
IS 5
BP 745
EP 757
DI 10.1007/s11524-016-0069-2
PG 13
WC Public, Environmental & Occupational Health; Medicine, General &
   Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; General & Internal Medicine
GA DY3WD
UT WOS:000385026200001
PM 27613180
OA Green Published
DA 2025-06-11
ER

PT J
AU Chakraborti, A
   Graham, C
   Chehade, S
   Vashi, B
   Umfress, A
   Kurup, P
   Vickers, B
   Chen, HA
   Telange, R
   Berryhill, T
   van der Pol, W
   Powell, M
   Barnes, S
   Morrow, C
   Smith, DL
   Mukhtar, MS
   Watts, S
   Kennedy, G
   Bibb, J
AF Chakraborti, Ayanabha
   Graham, Christopher
   Chehade, Sophie
   Vashi, Bijal
   Umfress, Alan
   Kurup, Pradeep
   Vickers, Benjamin
   Chen, H. Alexander
   Telange, Rahul
   Berryhill, Taylor
   van der Pol, William
   Powell, Mickie
   Barnes, Stephen
   Morrow, Casey
   Smith, Daniel L., Jr.
   Mukhtar, M. Shahid
   Watts, Stephen
   Kennedy, Gregory
   Bibb, James
TI High Fructose Corn Syrup-Moderate Fat Diet Potentiates Anxio-Depressive
   Behavior and Alters Ventral Striatal Neuronal Signaling
SO FRONTIERS IN NEUROSCIENCE
LA English
DT Article
DE diet; high fructose corn syrup (HFCS); anxiety; depression; nucleus
   accumbens; tryptophan; serotonin
ID GLYCOGEN-SYNTHASE KINASE-3; METABOLIC SYNDROME; NUCLEUS-ACCUMBENS;
   DELTA-FOSB; KYNURENINE PATHWAY; OBESITY; INSULIN; TRYPTOPHAN; DOPAMINE;
   STRESS
AB The neurobiological mechanisms that mediate psychiatric comorbidities associated with metabolic disorders such as obesity, metabolic syndrome and diabetes remain obscure. High fructose corn syrup (HFCS) is widely used in beverages and is often included in food products with moderate or high fat content that have been linked to many serious health issues including diabetes and obesity. However, the impact of such foods on the brain has not been fully characterized. Here, we evaluated the effects of long-term consumption of a HFCS-Moderate Fat diet (HFCS-MFD) on behavior, neuronal signal transduction, gut microbiota, and serum metabolomic profile in mice to better understand how its consumption and resulting obesity and metabolic alterations relate to behavioral dysfunction. Mice fed HFCS-MFD for 16 weeks displayed enhanced anxiogenesis, increased behavioral despair, and impaired social interactions. Furthermore, the HFCS-MFD induced gut microbiota dysbiosis and lowered serum levels of serotonin and its tryptophan-based precursors. Importantly, the HFCS-MFD altered neuronal signaling in the ventral striatum including reduced inhibitory phosphorylation of glycogen synthase kinase 3 beta (GSK3 beta), increased expression of Delta FosB, increased Cdk5-dependent phosphorylation of DARPP-32, and reduced PKA-dependent phosphorylation of the GluR1 subunit of the AMPA receptor. These findings suggest that HFCS-MFD-induced changes in the gut microbiota and neuroactive metabolites may contribute to maladaptive alterations in ventral striatal function that underlie neurobehavioral impairment. While future studies are essential to further evaluate the interplay between these factors in obesity and metabolic syndrome-associated behavioral comorbidities, these data underscore the important role of peripheral-CNS interactions in diet-induced behavioral and brain function. This study also highlights the clinical need to address neurobehavioral comorbidities associated with obesity and metabolic syndrome.
C1 [Chakraborti, Ayanabha; Graham, Christopher; Vashi, Bijal; Umfress, Alan; Kurup, Pradeep; Vickers, Benjamin; Chen, H. Alexander; Telange, Rahul; Kennedy, Gregory; Bibb, James] Univ Alabama Birmingham, Dept Surg, Birmingham, AL 35294 USA.
   [Chehade, Sophie; Powell, Mickie; Mukhtar, M. Shahid; Watts, Stephen] Univ Alabama Birmingham, Dept Biol, Birmingham, AL 35294 USA.
   [Berryhill, Taylor; Barnes, Stephen] Univ Alabama Birmingham, Med Ctr, Dept Pharmacol, Birmingham, AL 35294 USA.
   [van der Pol, William] Univ Alabama Birmingham, Ctr Clin & Translat Sci, Birmingham, AL USA.
   [Morrow, Casey] Univ Alabama Birmingham, Dept Cell Dev & Integrat Biol, Birmingham, AL USA.
   [Smith, Daniel L., Jr.] Univ Alabama Birmingham, Dept Nutr Sci, Birmingham, AL 35294 USA.
C3 University of Alabama System; University of Alabama Birmingham;
   University of Alabama System; University of Alabama Birmingham;
   University of Alabama System; University of Alabama Birmingham;
   University of Alabama System; University of Alabama Birmingham;
   University of Alabama System; University of Alabama Birmingham;
   University of Alabama System; University of Alabama Birmingham
RP Bibb, J (corresponding author), Univ Alabama Birmingham, Dept Surg, Birmingham, AL 35294 USA.
EM jbibb@uab.edu
RI Telange, Rahul/AAH-3688-2021; Chakraborti, Ayanabha/N-1898-2019; Kurup,
   Pradeep/F-1291-2010
OI Smith Jr, Daniel/0000-0002-1602-2023; Chakraborti,
   Ayanabha/0000-0003-2060-8200; Telange, Rahul/0000-0002-6368-8223; ,
   Herbert Alexander Chen-MacLean/0000-0003-4185-7716; Umfress,
   Alan/0009-0002-1715-560X
FU NIH [R01MH116896]
FX This research was supported by NIH R01MH116896 (JB).
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NR 107
TC 14
Z9 14
U1 1
U2 12
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1662-453X
J9 FRONT NEUROSCI-SWITZ
JI Front. Neurosci.
PD MAY 26
PY 2021
VL 15
AR 669410
DI 10.3389/fnins.2021.669410
PG 16
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA SO6MR
UT WOS:000659085300001
PM 34121997
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Oh, SH
   Son, SH
   Kang, SH
   Kim, DK
   Seo, KM
   Lee, SY
AF Oh, Sang Ho
   Son, Sun Han
   Kang, Si Hyun
   Kim, Don-Kyu
   Seo, Kyung Mook
   Lee, Sang Yoon
TI Relationship Between Types of Exercise and Quality of Life in a Korean
   Metabolic Syndrome Population: A Cross-Sectional Study
SO METABOLIC SYNDROME AND RELATED DISORDERS
LA English
DT Article
DE metabolic syndrome X; quality of life; resistance training; muscle
   stretching exercise; walking
ID PHYSICAL-ACTIVITY; RISK-FACTORS; INTERVENTION PROGRAM; ADULTS; EQ-5D;
   CANCER; INDIVIDUALS; ASSOCIATION; VALIDATION; VALIDITY
AB Background: Metabolic syndrome (MetS) significantly correlates with exercise. MetS also has an independent and inverse correlation to quality of life (QoL). However, few studies have examined the association between exercise and QoL in people with MetS. The aim of this study was to ascertain the relationship between exercise and QoL in a MetS population.
   Methods: This was a cross-sectional study using public data from the Sixth Korean National Health and Nutrition Examination Survey in 2014 (n = 7550). MetS was defined on the basis of the revised National Cholesterol Education Program criteria. Demographic factors, three types of exercise (resistance, flexibility, walking), five subsets of EuroQoL (mobility, self-care, usual activities, pain/discomfort, anxiety/depression), and QoL scores (EQ-VAS), were investigated. Independent associations of each exercise on five subsets of QoL were determined using odds ratios (OR) adjusted for four demographic factors (age group, sex, weight change, and area of residence) using multivariate logistic regression analysis.
   Results: Prevalence of MetS was 26.4% and the ratio of subjects performing resistance, flexibility, or walking exercise was 17.7%, 45.8%, and 71.5% among this population, respectively. EQ-VAS of exercisers was significantly higher than that of non-exercisers in resistance, flexibility, and walking exercise. Although resistance and flexibility exercise did not correlate with any subsets of QoL, mobility and self-care were significantly associated with walking exercise (OR = 0.635, 95% CI = 0.439-0.919 and OR = 0.577, 95% CI = 0.348-0.958, respectively).
   Conclusions: All exercisers showed higher QoL scores than non-exercisers. Among QoL subsets, mobility and self-care were independently associated with walking exercise in the MetS population. Regular walking exercise was important to higher QoL in those with MetS. This is the first clinical report to indicate that QoL could be independently influenced by walking exercise.
C1 [Oh, Sang Ho; Son, Sun Han; Kang, Si Hyun; Kim, Don-Kyu; Seo, Kyung Mook; Lee, Sang Yoon] Chung Ang Univ, Coll Med, Dept Phys Med & Rehabil, Seoul, South Korea.
   [Lee, Sang Yoon] Seoul Natl Univ, Boramae Med Ctr, Dept Rehabil Med, Seoul, South Korea.
C3 Chung Ang University; Chung Ang University Hospital; Seoul National
   University (SNU); Seoul National University Hospital
RP Lee, SY (corresponding author), Chung Ang Univ Hosp, Dept Phys Med & Rehabil, 102 Heukseok Ro, Seoul 06973, South Korea.
EM rehabilee@gmail.com
RI Oh, Sang Ho/ISV-3878-2023; Lee, Sang/AAD-5045-2019
FU Health Promotion Fund
FX The KNHANES has been financially supported by the Health Promotion Fund
   with administrative support by the Ministry of Health and Welfare.
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Z9 12
U1 1
U2 11
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-4196
EI 1557-8518
J9 METAB SYNDR RELAT D
JI Metab. Syndr. Relat. Disord.
PD MAY
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VL 15
IS 4
BP 199
EP 205
DI 10.1089/met.2016.0151
PG 7
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Research & Experimental Medicine
GA ET2MG
UT WOS:000400106700007
PM 28287907
DA 2025-06-11
ER

PT J
AU Mazloomi, SM
AF Mazloomi, S. M.
TI EXPRESSION OF CONCERN: The Effect of Spirulina Sauce, as a Functional
   Food, on Cardiometabolic Risk Factors, Oxidative Stress Biomarkers,
   Glycemic Profile, and Liver Enzymes in Nonalcoholic Fatty Liver Disease
   Patients: A Randomized Double-blinded Clinical Trial
SO FOOD SCIENCE & NUTRITION
LA English
DT Article
RI Mazloomi, Seyed/K-1625-2013
NR 0
TC 0
Z9 0
U1 2
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2048-7177
J9 FOOD SCI NUTR
JI Food Sci. Nutr.
PD FEB
PY 2025
VL 13
IS 2
AR e70006
DI 10.1002/fsn3.70006
PG 1
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA U6N9F
UT WOS:001412947600001
PM 39901988
OA hybrid
DA 2025-06-11
ER

PT J
AU Cook, CE
   Zhou, L
   Bolognesi, M
   Sheean, AJ
   Barlow, BT
   Rhon, DI
AF Cook, Chad E.
   Zhou, Liang
   Bolognesi, Michael
   Sheean, Andrew J.
   Barlow, Brian T.
   Rhon, Daniel, I
TI Does Surgery for Concomitant Cruciate and Meniscus Injuries Increase or
   Decrease Subsequent Comorbidities at 2 Years?
SO JOURNAL OF KNEE SURGERY
LA English
DT Article
DE surgery; military; injury; knee; cruciate ligament; meniscus
ID QUALITY-OF-LIFE; LIGAMENT INJURY; ANTERIOR; OUTCOMES; TEAR;
   COMPLICATIONS; RECONSTRUCTION; DISORDERS; PATTERNS; IMPACT
AB Concomitant cruciate and meniscus injuries of the knee are generally associated with acute trauma and commonly treated with surgical intervention. Comorbidities (simultaneous presence of two or more medical conditions) may be acquired from changes in activity levels and lifestyle after an injury and/or treatment. This study aimed to compare differences in comorbidity proportions between surgical and nonsurgical approaches in Military Health System beneficiaries who had concurrent cruciate and meniscus injuries. The retrospective case control design included 36-month data that were analyzed to reflect 12 months prior to injury/surgery and 24 months after injury/surgery. A comparison of differences within and between groups in surgical and nonsurgical approaches was calculated and logistic regression was used to determine if surgery increased or decreased the odds of comorbidities at 24 months. In our sample of 2,438 individuals with concurrent meniscus and cruciate injury, 79.1% ( n = 1,927) received surgical intervention and 20.9% ( n = 511) elected for nonoperative management. All comorbidities demonstrated significant within-group differences from pre- to postsurgery for those with a surgical intervention; approximately, half the comorbidities increased (i.e., concussion or traumatic brain injury, insomnia, other sleep disorders, anxiety, posttraumatic stress disorder, and tobacco abuse disorder), whereas the other half decreased (i.e., chronic pain, apnea, cardiovascular disease, metabolic syndrome, mental health other, depression, and substance abuse disorders). The odds of acquiring a comorbid diagnosis after surgery reflected the bivariate comparisons with half increasing and half decreasing in odds. To our knowledge, this is the first study to explore comorbidity changes with a control group for individuals with concurrent meniscus and cruciate injuries.
C1 [Cook, Chad E.; Bolognesi, Michael] Duke Univ, Dept Orthopaed, Durham, NC 27710 USA.
   [Cook, Chad E.] Dept Populat Hlth Sci, Durham, NC USA.
   [Cook, Chad E.; Rhon, Daniel, I] Duke Clin Res Inst, Durham, NC USA.
   [Zhou, Liang] Tripler Army Med Ctr, Oahu, HI USA.
   [Sheean, Andrew J.] Brooke Army Med Ctr, Dept Orthopaed Surg, San Antonio, TX USA.
   [Rhon, Daniel, I] Brooke Army Med Ctr, Dept Rehabil Med, San Antonio, TX USA.
   [Barlow, Brian T.; Rhon, Daniel, I] Naval Med Ctr San Diego, San Diego, CA USA.
C3 Duke University; Duke University; Tripler Army Medical Center; United
   States Department of Defense; United States Army; San Antonio Military
   Medical Center; United States Department of Defense; United States Army;
   United States Department of Defense; United States Army; San Antonio
   Military Medical Center; United States Department of Defense; United
   States Navy; Naval Medical Center San Diego
RP Cook, CE (corresponding author), Duke Univ, 311 Trent Dr, Durham, NC 27710 USA.
EM chad.cook@duke.edu
RI Rhon, Daniel/C-9542-2011
OI Cook, Chad/0000-0001-8622-8361; Rhon, Daniel/0000-0002-4320-990X
FU Uniformed Services University, Department of Physical Medicine and
   Rehabilitation, Musculoskeletal Injury Rehabilitation Research for
   Operational Readiness (MIRROR) [HU00011920011]
FX This work was supported in part by the Uniformed Services University,
   Department of Physical Medicine and Rehabilitation, Musculoskeletal
   Injury Rehabilitation Research for Operational Readiness (MIRROR; grant
   no.: HU00011920011).
CR Ahn J, 2019, KNEE SURG RELAT RES, V31
   [Anonymous], TOBACCO USE MILITARY
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NR 36
TC 3
Z9 3
U1 0
U2 3
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 1538-8506
EI 1938-2480
J9 J KNEE SURG
JI J. Knee Surg.
PD AUG
PY 2022
VL 35
IS 10
BP 1063
EP 1070
DI 10.1055/s-0042-1750046
EA JUL 2022
PG 8
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA 3V3EK
UT WOS:000826650500001
PM 35850133
DA 2025-06-11
ER

PT J
AU Farinha, JB
   Dos Santos, DL
   Bresciani, G
   Bard, LF
   de Mello, F
   Stefanello, ST
   Courtes, AA
   Soares, FAA
AF Farinha, J. B.
   Dos Santos, D. L.
   Bresciani, G.
   Bard, L. F.
   de Mello, F.
   Stefanello, S. T.
   Courtes, A. A.
   Soares, F. A. A.
TI Weight loss is not mandatory for exercise-induced effects on health
   indices in females with metabolic syndrome
SO BIOLOGY OF SPORT
LA English
DT Article
DE metabolic syndrome X; women; exercise; quality of life; weight loss
ID QUALITY-OF-LIFE; OBESE ADULTS; INDIVIDUALS; INFLAMMATION; CHOLESTEROL;
   OVERWEIGHT; STRESS; PLASMA; SERUM; ACID
AB The aim of this study was to investigate the impact of moderate aerobic training on functional, anthropometric, biochemical, and health-related quality of life (HRQOL) parameters on women with metabolic syndrome (MS). Fifteen untrained women with MS performed moderate aerobic training for 15 weeks, without modifications of dietary behaviours. Functional, anthropometric, biochemical, control diet record and HRQOL parameters were assessed before and after the training. Despite body weight maintenance, the patients presented decreases in waist circumference (P=0.001), number of MS components (P=0.014), total cholesterol (P=0.049), HDL cholesterol (P=0.004), LDL cholesterol (P=0.027), myeloperoxidase activity (P=0.002) and thiobarbituric acid-reactive substances levels (P=0.006). There were no differences in total energy, carbohydrate, protein and lipid intake pre- and post-training. Furthermore, improvements in the HRQOL subscales of physical functioning (P=0.03), role-physical (P=0.039), bodily pain (P=0.048), general health (P=0.046) and social functioning scoring (P=0.011) were reported. Despite the absence of weight loss, aerobic training induced beneficial effects on functional, anthropometric, biochemical and HRQOL parameters in women with MS.
C1 [Farinha, J. B.; Dos Santos, D. L.; Bard, L. F.; de Mello, F.] Univ Fed Santa Maria, Ctr Educ Fis & Desportos, Dept Metodos & Tecn Desportivas, BR-97105900 Santa Maria, RS, Brazil.
   [Bresciani, G.; Stefanello, S. T.; Courtes, A. A.; Soares, F. A. A.] Univ Fed Santa Maria, Ctr Ciencias Nat & Exatas, Dept Quim, BR-97105900 Santa Maria, RS, Brazil.
   [Bresciani, G.] Univ Autonoma Chile, Temuco, Chile.
C3 Universidade Federal de Santa Maria (UFSM); Universidade Federal de
   Santa Maria (UFSM); Universidad Autonoma de Chile
RP Soares, FAA (corresponding author), Univ Fed Santa Maria, Ctr Ciencias Nat & Exatas, Dept Quim, BR-97105900 Santa Maria, RS, Brazil.
EM felix@ufsm.br
RI Farinha, Juliano/HDN-8796-2022; Bresciani, Guilherme/M-6805-2014; dos
   Santos, Daniela/AAU-2310-2021; Stefanello, Silvio Terra/I-3106-2014;
   Soares, Felix/K-7611-2012
OI Stefanello, Silvio Terra/0000-0002-6673-6550; Bresciani,
   Guilherme/0000-0003-1526-5573; Boufleur Farinha,
   Juliano/0000-0003-4589-256X; Soares, Felix/0000-0002-6453-7902; Santos,
   Daniela/0000-0002-1782-1337
FU CAPES (Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior);
   UFSM/FIPE (Fundo de Incentivo a Pesquisa); CNPq (Conselho Nacional de
   Desenvolvimento Cientifico e Tecnologico); FAPERGS/CNPq - PRONEM
   (Programa de Apoio a Nucleos Emergentes) [11/2029-1]
FX We greatly thank Dr. Carlos Bolli Mota and Proximus Tecnologia for the
   technical support and research incentive. J.B.F., G.B. and S.T.S.
   received fellowship from CAPES (Coordenacao de Aperfeicoamento de
   Pessoal de Nivel Superior). F.D.M. received a fellowship from UFSM/FIPE
   (Fundo de Incentivo a Pesquisa). F.A.A.S. received a fellowship from
   CNPq (Conselho Nacional de Desenvolvimento Cientifico e Tecnologico).
   Additional financial support was given by FAPERGS/CNPq - PRONEM
   #11/2029-1 (Programa de Apoio a Nucleos Emergentes).
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NR 29
TC 9
Z9 10
U1 0
U2 3
PU TERMEDIA PUBLISHING HOUSE LTD
PI POZNAN
PA KLEEBERGA ST 2, POZNAN, 61-615, POLAND
SN 0860-021X
EI 2083-1862
J9 BIOL SPORT
JI Biol. Sport
PY 2015
VL 32
IS 2
BP 109
EP 114
DI 10.5604/20831862.1134313
PG 6
WC Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Sport Sciences
GA CM3BK
UT WOS:000357556400004
PM 26028810
DA 2025-06-11
ER

PT J
AU Seo, Y
   Lee, S
   Ahn, JS
   Min, S
   Kim, MH
   Kim, JY
   Kang, DR
   Hwang, S
   Vicheka, P
   Lee, J
AF Seo, Yongseok
   Lee, Seungyeon
   Ahn, Joung-Sook
   Min, Seongho
   Kim, Min-Hyuk
   Kim, Jang-Young
   Kang, Dae Ryong
   Hwang, Sangwon
   Vicheka, Phor
   Lee, Jinhee
TI Association of Metabolically Healthy Obesity and Future Depression:
   Using National Health Insurance System Data in Korea from 2009-2017
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Article
DE metabolically healthy obese phenotype; metabolic syndrome; obesity;
   depression
ID MYOCARDIAL-INFARCTION; RISK; SYMPTOMS; OVERWEIGHT; MORTALITY;
   EPIDEMIOLOGY; INFLAMMATION; METAANALYSIS; POPULATION; DISORDER
AB (1) Background: The health implications associated with the metabolically healthy obese (MHO) phenotype, in particular related to symptoms of depression, are still not clear. the purpose of this study is to check whether depression and metabolic status are relevant by classifying them into four groups in accordance with the MHO diagnostic standard. Other impressions seen were the differences between sexes and the effects of the MHO on the occurrence of depression. (2) Methods: A sample of 3,586,492 adult individuals from the National Health Insurance Database of Korea was classified into four categories by their metabolic status and body mass index: (1) metabolically healthy non-obese (MHN); (2) metabolically healthy obese (MHO); (3) metabolically unhealthy non-obese (MUN); and (4) metabolically unhealthy obese (MUO). Participants were followed for six to eight years for new incidences of depression. The statistical significance of the general characteristics of the four groups, as well as the mean differences in metabolic syndrome risk factors, was assessed with the use of a one-way analysis of variance (ANOVA). (3) Results: The MHN ratio in women was higher than in men (men 39.3%, women 55.2%). In both men and women, depression incidence was the highest among MUO participants (odds ratio (OR) = 1.01 in men; OR = 1.09 in women). It was concluded as well that, among the risk factors of metabolic syndrome, waist circumference was the most related to depression. Among the four groups, the MUO phenotype was the most related to depression. Furthermore, in women participants, MHO is also related to a higher risk of depressive symptoms. These findings indicate that MHO is not a totally benign condition in relation to depression in women. (4) Conclusion: Therefore, reducing metabolic syndrome and obesity patients in Korea will likely reduce the incidence of depression.
C1 [Seo, Yongseok; Lee, Seungyeon] Yonsei Univ, Wonju Coll Med, Wonju 26426, South Korea.
   [Ahn, Joung-Sook; Min, Seongho; Kim, Min-Hyuk; Lee, Jinhee] Yonsei Univ, Wonju Coll Med, Dept Psychiat, Wonju 26426, South Korea.
   [Kim, Jang-Young] Yonsei Univ, Wonju Coll Med, Dept Internal Med, Wonju 26426, South Korea.
   [Kang, Dae Ryong] Yonsei Univ, Wonju Coll Med, Dept Precis Med, Wonju 26426, South Korea.
   [Hwang, Sangwon; Vicheka, Phor] Yonsei Univ, Wonju Coll Med, Inst AI & Big Data Med, Wonju 26426, South Korea.
C3 Yonsei University; Yonsei University; Yonsei University; Yonsei
   University; Yonsei University
RP Lee, J (corresponding author), Yonsei Univ, Wonju Coll Med, Dept Psychiat, Wonju 26426, South Korea.
EM s_ys_@naver.com; yeonnii96@gmail.com; jsahn@yonsei.ac.kr;
   mchorock@yonsei.ac.kr; mhkim09@yonsei.ac.kr; kimjy@yonsei.ac.kr;
   dr.kang@yonsei.ac.kr; arsenal@yonsei.ac.kr; phorvicheka@yahoo.com;
   jinh.lee95@yonsei.ac.kr
RI Kim, Nam Hoon/HNS-5794-2023; Lee, Jee-Yon/GER-4141-2022; Kim,
   Min-Hyuk/ITV-2946-2023; Hwang, Sangwon/ISS-8990-2023
OI Kang, Dae Ryong/0000-0002-8792-9730; Lee, Seungyeon/0000-0001-6082-3082;
   Min, Seongho/0000-0003-1084-7822; Min-Hyuk, Kim/0000-0002-6130-3254;
   seo, yongseog/0000-0002-1563-3156; Lee, Jinhee/0000-0003-4255-1831
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NR 35
TC 8
Z9 9
U1 0
U2 6
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD JAN
PY 2021
VL 18
IS 1
AR 63
DI 10.3390/ijerph18010063
PG 9
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA PP7OI
UT WOS:000606047200001
PM 33374826
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Jurgens, SM
   Prieto, S
   Hayes, JP
AF Jurgens, Savana M.
   Prieto, Sarah
   Hayes, Jasmeet P.
TI Inflammatory biomarkers link perceived stress with metabolic
   dysregulation
SO BRAIN BEHAVIOR & IMMUNITY-HEALTH
LA English
DT Article
DE Stress; Inflammation; Metabolic syndrome; Cardiovascular disease; Type
   II diabetes
ID C-REACTIVE PROTEIN; INSULIN-RESISTANCE; PSYCHOSOCIAL STRESS;
   IMMUNE-RESPONSES; UNITED-STATES; HEALTH; HYPERTENSION; DEFINITIONS;
   ASSOCIATION; CORTISOL
AB Objective: Perceived stress has been identified as a risk factor for metabolic syndrome. However, the intermediate pathways underlying this relationship are not well understood. Inflammatory responses may be one process by which stress leads to metabolic dysregulation. Prior work has shown that chronic stress is associated with elevated systemic inflammation and that altered inflammatory activity contributes to the pathogenesis of metabolic syndrome. The current analyses tested this hypothesis by examining inflammation as a pathway by which perceived stress affects metabolic health. Methods: Data from the Midlife in the United States Study (MIDUS) (N = 648; Mean age = 52.3) provided measures of perceived stress, inflammatory biomarkers [C-reactive protein (CRP), interleukin-6 (IL-6), E-selectin, fibrinogen, intracellular adhesion molecule-1 (ICAM-1)] and metabolic health markers. Confirmatory factor analysis (CFA) was used to confirm the fit of a hierarchical model of metabolic syndrome in our sample. Structural equation modeling (SEM) was used to test the assumption that inflammation mediates the association between perceived stress and the latent factor representing metabolic syndrome. Results: The CFA of metabolic syndrome demonstrated excellent goodness of fit to our sample [CFI = 0.97, TLI = 0.95, RMSEA = 0.06, SMSR = 0.05]. Mediation analysis with SEM revealed that the indirect pathway linking stress to metabolic dysregulation through inflammation was significant [B = 0.08, SE = 0.01, z = 3.69, p < .001, 95% confidence interval CI (0.04, 0.13)]. Conclusions: These results suggest that inflammatory biomarkers are a viable explanatory pathway for the relationship between perceived stress and metabolic health consequences. Interventions that target psychosocial stress may serve as cost-effective and accessible treatment options for mitigating inflammatory health risks.
C1 [Jurgens, Savana M.; Prieto, Sarah; Hayes, Jasmeet P.] Ohio State Univ, Dept Psychol, Columbus, OH USA.
   [Hayes, Jasmeet P.] Ohio State Univ, Chron Brain Injury Initiat, Columbus, OH USA.
   [Hayes, Jasmeet P.] Psychol Bldg 235, 1835 Neil Ave, Columbus, OH 43210 USA.
C3 University System of Ohio; Ohio State University; University System of
   Ohio; Ohio State University
RP Hayes, JP (corresponding author), Psychol Bldg 235, 1835 Neil Ave, Columbus, OH 43210 USA.
EM hayes.1075@osu.edu
RI Hayes, Jasmeet/AAN-4150-2020
OI Prieto, Sarah/0000-0001-5697-3010; Hayes, Jasmeet/0000-0002-5157-0666
FU National Institute on Aging (NIA) of the National Institutes of Health
   (NIH) [R01AG058822]; Ohio State University Discovery Themes Chronic
   Brain Injury Initiative; John D. and Catherine T. MacArthur Foundation
   Research Network; NIA [P01-AG020166, U19-AG051426]; NIH National Center
   for Advancing Translational Sciences (NCATS) Clinical and Translational
   Science Award (CTSA) program [UL1TR001409, UL1TR001881, 1UL1RR025011]
FX This work was supported by the National Institute on Aging (NIA) of the
   National Institutes of Health (NIH; R01AG058822; Jasmeet P. Hayes) and
   The Ohio State University Discovery Themes Chronic Brain Injury
   Initiative (Jasmeet P. Hayes). Since 1995, funding for MIDUS has been
   sourced from the John D. and Catherine T. MacArthur Foundation Research
   Network, NIA (P01-AG020166) and NIA (U19-AG051426). Additional support
   for the Biomarkers project was provided from the NIH National Center for
   Advancing Translational Sciences (NCATS) Clinical and Translational
   Science Award (CTSA) program as follows: UL1TR001409 (Georgetown);
   UL1TR001881 (UCLA); 1UL1RR025011 (UW).
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NR 77
TC 5
Z9 5
U1 2
U2 3
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2666-3546
J9 BRAIN BEHAV IMMUN-HL
JI Brain Behav. Immun.-Health
PD DEC
PY 2023
VL 34
AR 100696
DI 10.1016/j.bbih.2023.100696
EA OCT 2023
PG 7
WC Immunology; Neurosciences; Psychiatry
WE Emerging Sources Citation Index (ESCI)
SC Immunology; Neurosciences & Neurology; Psychiatry
GA IH5J2
UT WOS:001165446600001
PM 37928770
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Rakugi, H
   Kamide, K
   Ogihara, T
AF Rakugi, H
   Kamide, K
   Ogihara, T
TI Vascular signaling pathways in the metabolic syndrome
SO CURRENT HYPERTENSION REPORTS
LA English
DT Article
ID NECROSIS-FACTOR-ALPHA; CONVERTING ENZYME-INHIBITOR;
   MACROPHAGE-GENE-EXPRESSION; SMOOTH-MUSCLE-CELLS; INSULIN-RESISTANCE;
   PPAR-GAMMA; CARDIOVASCULAR COMPLICATIONS; ENDOTHELIAL-CELLS; OXIDATIVE
   STRESS; SYNDROME-X
AB There are several potential cellular and molecular pathways whereby cardiovascular risk factors act through very specific signal transduction pathways in the formation of atherosclerosis, as seen often in the metabolic syndrome. Many examples point to multiple postreceptor defects in the insulin signaling pathway in vascular tissue, however, there are differences in the insulin receptor pathway in vascular tissue compared with skeletal muscle or fat. In addition to insulin receptors, insulin may affect atherosclerotic changes in the vascular cells via stimulation of insulin-like growth factor-I receptors and their signaling pathway. Insulin also causes activation of the vascular renin-angiotensin system in both vascular smooth muscle cells and endothelial cells. Insulin-activated tissue renin-angiotensin system leads to increased cell growth and contributes to the cause of atherosclerosis. The fact that agents that inhibit the renin-angiotensin system also block insulin-mediated renin-angiotensin system expression and cell growth reinforces the potential implication of a vascular insulin-renin-angiotensin system pathway. Finally, novel substances such as the adipokines, factors produced from fat cells, reveal new risk factors in the metabolic syndrome and offer further evidence for a link between insulin resistance and accelerated atherosclerosis.
C1 Osaka Univ, Dept Geriatr Med B6, Grad Sch Med, Suita, Osaka 5650871, Japan.
C3 The University of Osaka
RP Osaka Univ, Dept Geriatr Med B6, Grad Sch Med, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan.
EM rakugi@geriat.med.osaka-u.ac.jp
RI Rakugi, Hiromi/ADM-3795-2022
OI Rakugi, Hiromi/0000-0001-6508-4338
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NR 45
TC 19
Z9 20
U1 1
U2 2
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1522-6417
EI 1534-3111
J9 CURR HYPERTENS REP
JI Curr. Hypertens. Rep.
PD APR
PY 2002
VL 4
IS 2
BP 105
EP 111
DI 10.1007/s11906-002-0034-1
PG 7
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 616TN
UT WOS:000179319200003
PM 11884265
DA 2025-06-11
ER

PT J
AU Szafoni, S
   Piegza, M
AF Szafoni, Sandra
   Piegza, Magdalena
TI Progress in Personalized Psychiatric Therapy with the Example of Using
   Intranasal Oxytocin in PTSD Treatment
SO JOURNAL OF PERSONALIZED MEDICINE
LA English
DT Review
DE PTSD; personalized medicine; individualized treatment; intranasal
   oxytocin; psychotherapy
ID POSTTRAUMATIC-STRESS-DISORDER; CORTICOTROPIN-RELEASING-FACTOR; PROLONGED
   EXPOSURE THERAPY; PLACEBO-CONTROLLED TRIAL; METABOLIC SYNDROME;
   D-CYCLOSERINE; RECEPTOR; PSYCHOTHERAPY; METAANALYSIS; SYMPTOMS
AB Post-traumatic stress disorder (PTSD) is a severe mental disorder that results in the frequent coexistence of other diseases, lowers patients ' quality of life, and has a high annual cost of treatment. However, despite the variety of therapeutic approaches that exist, some patients still do not achieve the desired results. In addition, we may soon face an increase in the number of new PTSD cases because of the current global situation-both the COVID-19 pandemic and the ongoing armed conflicts. Hence, in recent years, many publications have sought a new, more personalized treatment approach. One such approach is the administration of intranasal oxytocin (INOXT), which, due to its pleiotropic effects, seems to be a promising therapeutic option. However, the current findings suggest that it might only be helpful for a limited, strictly selected group of patients.
C1 [Szafoni, Sandra; Piegza, Magdalena] Med Univ Silesia, Fac Med Sci Zabrze, Dept Psychiat, PL-42612 Tarnowskie Gory, Poland.
C3 Medical University of Silesia
RP Szafoni, S (corresponding author), Med Univ Silesia, Fac Med Sci Zabrze, Dept Psychiat, PL-42612 Tarnowskie Gory, Poland.
EM sandra.szafoni@gmail.com; mpiegza@sum.edu.pl
RI Szafoni, Sandra/KBR-2909-2024
OI Piegza, Magdalena/0000-0002-8009-7118; Szafoni,
   Sandra/0000-0003-4980-5734
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NR 97
TC 3
Z9 4
U1 0
U2 3
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2075-4426
J9 J PERS MED
JI J. Pers. Med.
PD JUL
PY 2022
VL 12
IS 7
AR 1067
DI 10.3390/jpm12071067
PG 13
WC Health Care Sciences & Services; Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Health Care Sciences & Services; General & Internal Medicine
GA 3J0JW
UT WOS:000833092500001
PM 35887564
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Nicol, GE
   Morrato, EH
   Johnson, MC
   Campagna, E
   Yingling, MD
   Pham, V
   Newcomer, JW
AF Nicol, Ginger E.
   Morrato, Elaine H.
   Johnson, Mark C.
   Campagna, Elizabeth
   Yingling, Michael D.
   Pham, Victor
   Newcomer, John W.
TI Best Practices Implementation of a Glucose Screening Program Based on
   Diffusion of Innovation Theory Methods
SO PSYCHIATRIC SERVICES
LA English
DT Article
ID ANTIPSYCHOTIC-DRUGS
AB There is public health interest in the identification and treatment of modifiable cardiometabolic risk factors among patients treated with antipsychotic medications. However, best-practice screening recommendations endorsed by multiple medical organizations have not translated into real-world clinical practice. Quality improvement strategies may help to address the gap between policy and implementation. This column describes the successful implementation of a best-practice glucose screening program in a large network of community mental health centers that was based on Six Sigma and diffusion of innovation theory. (Psychiatric Services 62:12-14, 2011)
C1 [Nicol, Ginger E.; Yingling, Michael D.; Newcomer, John W.] Washington Univ, Sch Med, Dept Psychiat, St Louis, MO 63110 USA.
   [Morrato, Elaine H.; Campagna, Elizabeth] Univ Colorado Denver, Colorado Hlth Outcomes Program, Aurora, CO USA.
   [Johnson, Mark C.] BJC Behav Hlth, St Louis, MO USA.
   [Pham, Victor] Barnes Jewish Hosp, St Louis, MO 63110 USA.
C3 Washington University (WUSTL); University of Colorado System; University
   of Colorado Anschutz Medical Campus; Children's Hospital Colorado;
   Washington University (WUSTL); Barnes-Jewish Hospital
RP Nicol, GE (corresponding author), Washington Univ, Sch Med, Dept Psychiat, 660 S Euclid Ave,Campus Box 8134, St Louis, MO 63110 USA.
EM nicolg@wustl.edu
RI Nicol, Ginger/AAN-1176-2021
OI Nicol, Ginger/0000-0001-5823-6129; Newcomer, John/0000-0003-2153-9382
FU Bristol-Myers Squibb; Janssen Pharmaceuticals; Pfizer
FX Dr. Newcomer has received research grant support from Bristol-Myers
   Squibb, Janssen Pharmaceuticals, and Pfizer. He has served as a
   consultant to AstraZeneca, Bristol-Myers Squibb, Biovail, Obecure,
   Janssen Pharmaceuticals, H. Lundbeck, Pfizer and Sepracor/Sunovion. He
   has been a consultant to litigationi regarding medication effects. He
   has been a member of Data Safety Monitoring Boards for Dainippon
   Sumitomo Pharma America, Inc., Schering-Plough/MERCK, and Vivus, Inc. He
   has received royalties from Jones & Bartlett Publishers for a metabolic
   screening form.
CR Amer Diabet Assoc, 2004, DIABETES CARE, V27, P596, DOI 10.2337/diacare.27.2.596
   Druss BG, 2010, AM J PSYCHIAT, V167, P151, DOI 10.1176/appi.ajp.2009.09050691
   King Diane L, 2006, Emerg Med Australas, V18, P391, DOI 10.1111/j.1742-6723.2006.00872.x
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   Morrato EH, 2009, DIABETES CARE, V32, P1037, DOI 10.2337/dc08-1720
NR 6
TC 9
Z9 15
U1 0
U2 11
PU AMER PSYCHIATRIC PUBLISHING, INC
PI WASHINGTON
PA 800 MAINE AVE SW, SUITE 900, WASHINGTON, DC 20024 USA
SN 1075-2730
EI 1557-9700
J9 PSYCHIAT SERV
JI Psychiatr. Serv.
PD JAN
PY 2011
VL 62
IS 1
BP 12
EP 14
DI 10.1176/appi.ps.62.1.12
PG 3
WC Health Policy & Services; Public, Environmental & Occupational Health;
   Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services; Public, Environmental & Occupational
   Health; Psychiatry
GA 702SX
UT WOS:000285917200004
PM 21209293
DA 2025-06-11
ER

PT J
AU Bellis, A
   Trimarco, B
AF Bellis, Alessandro
   Trimarco, Bruno
TI Pharmacological approach to cardiovascular risk in metabolic syndrome
SO JOURNAL OF CARDIOVASCULAR MEDICINE
LA English
DT Review
DE cardiovascular risk; insulin resistance; metabolic syndrome; oxidative
   stress
ID TYPE-2 DIABETES-MELLITUS; ENDOTHELIAL NITRIC-OXIDE; INSULIN-RESISTANCE;
   NAD(P)H OXIDASE; PHYSICAL-ACTIVITY; OXIDATIVE STRESS; GLUCOSE-UPTAKE;
   BETA-BLOCKERS; NADPH OXIDASE; NEBIVOLOL
AB Metabolic syndrome is not a discrete entity with a single pathogenesis, but different complex mechanisms, especially those inducing oxidative stress, play a major role in the genesis of this condition. This consideration suggests that treatment of recognized cardiovascular risk factors alone cannot be enough to prevent cardiovascular events in patients with a diagnosed metabolic syndrome. However, it has been reported that oxidative stress is involved in the transduction of the effects of haemodynamic and metabolic pathological conditions. Thus, drugs acting on the renin-angiotensin system [angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers], or on the glucose or lipid metabolism as substrate of oxidative mechanisms (statins and nutraceuticals) in association with a dietary restriction may be taken in account, because they play a synergistic effect in preventing functional and structural changes responsible for the high cardiovascular risk in metabolic syndrome.
C1 [Bellis, Alessandro; Trimarco, Bruno] Univ Naples Federico II, Dept Clin Med Cardiovasc & Immunol Sci, I-80131 Naples, Italy.
C3 University of Naples Federico II
RP Bellis, A (corresponding author), Univ Naples Federico II, Dept Clin Med Cardiovasc & Immunol Sci, Via S Pansini 5, I-80131 Naples, Italy.
EM abellis82@vodafone.it
RI Trimarco, Bruno/K-7851-2016
OI Trimarco, Bruno/0000-0002-0701-6449
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NR 63
TC 4
Z9 4
U1 0
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1558-2027
EI 1558-2035
J9 J CARDIOVASC MED
JI J. Cardiovasc. Med.
PD JUN
PY 2013
VL 14
IS 6
BP 403
EP 409
DI 10.2459/JCM.0b013e32835dbd0d
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 298VU
UT WOS:000330353400002
PM 23337396
DA 2025-06-11
ER

PT J
AU de Heer, HD
   Balcazar, HG
   Rosenthal, EL
   Cardenas, VM
   Schulz, LO
AF de Heer, Hendrik Dirk
   Balcazar, Hector G.
   Rosenthal, E. Lee
   Cardenas, Victor M.
   Schulz, Leslie O.
TI Ethnic Pride and Cardiovascular Health Among Mexican American Adults
   Along the US-Mexico Border
SO HISPANIC JOURNAL OF BEHAVIORAL SCIENCES
LA English
DT Article
DE ethnic pride; diabetes; cardiovascular; metabolic syndrome; Hispanic;
   acculturation
ID UNITED-STATES; ACCULTURATION SCALE; MENTAL-HEALTH; RISK-FACTORS;
   SELF-ESTEEM; NHANES-III; DRUG-USE; IDENTITY; WOMEN; HISPANICS
AB This study addressed the association between items from the General Acculturation Index (GAI) and cardiovascular health. Specifically, we assessed whether ethnic pride was associated with health outcomes after controlling for items regarding language, place where the childhood was spent, and ethnic interaction. The study was a cross-sectional analysis of demographic and clinical data from a border population of Mexican American adults (n = 316) at risk for cardiovascular disease (CVD). Outcomes included smoking and diabetes status, Framingham risk, and metabolic syndrome. Ethnic pride was associated with lower diabetes prevalence, lower Framingham risk, and fewer risk factors for metabolic syndrome but was not associated with smoking status. Ethnic pride was not associated with the other acculturation items of the GAI. Among an at-risk border population, ethnic pride functioned independently of other acculturation indicators. Ethnic pride may act as a protective factor for diabetes, metabolic syndrome, and CVD risk status.
C1 [de Heer, Hendrik Dirk] Univ Texas El Paso, Dept Psychol, El Paso, TX 79968 USA.
   [Balcazar, Hector G.; Cardenas, Victor M.] Univ Texas Houston Hlth Sci Ctr, Sch Publ Hlth, El Paso, TX USA.
   [Rosenthal, E. Lee] Univ Texas El Paso, Coll Hlth Sci, Dept Publ Hlth Sci, El Paso, TX 79968 USA.
   [Schulz, Leslie O.] No Arizona Univ, Coll Hlth & Human Serv, Flag Staff, AZ USA.
C3 University of Texas System; University of Texas El Paso; University of
   Texas System; University of Texas Health Science Center Houston;
   University of Texas System; University of Texas El Paso
RP de Heer, HD (corresponding author), NHGRI, Social & Behav Res Branch, 31 Ctr Dr,Bldg 31,RM B1B37, Bethesda, MD 20892 USA.
EM dirk.deheer@nih.gov
RI de Heer, Hendrik/D-3192-2013
OI Cardenas, Victor M./0000-0002-7951-0980
FU NIMHD NIH HHS [R24 MD001785] Funding Source: Medline
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NR 46
TC 8
Z9 13
U1 0
U2 7
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0739-9863
EI 1552-6364
J9 HISPANIC J BEHAV SCI
JI Hisp. J. Behav. Sci.
PD MAY
PY 2011
VL 33
IS 2
BP 204
EP 220
DI 10.1177/0739986311406068
PG 17
WC Psychology, Multidisciplinary
WE Social Science Citation Index (SSCI)
SC Psychology
GA 759XB
UT WOS:000290280900005
PM 22610060
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Chichlowska, KL
   Rose, KM
   Diez-Roux, AV
   Golden, SH
   McNeill, AM
   Heiss, G
AF Chichlowska, Kristal L.
   Rose, Kathryn M.
   Diez-Roux, Ana V.
   Golden, Sherita H.
   McNeill, Annie M.
   Heiss, Gerardo
TI Individual and Neighborhood Socioeconomic Status Characteristics and
   Prevalence of Metabolic Syndrome: The Atherosclerosis Risk in
   Communities (ARIC) Study
SO PSYCHOSOMATIC MEDICINE
LA English
DT Article
DE SES; income; neighborhood; metabolic syndrome; syndrome X; insulin
   resistance; stress
ID CORONARY-HEART-DISEASE; 3RD NATIONAL-HEALTH; DENSITY-LIPOPROTEIN
   CHOLESTEROL; INCIDENT CARDIOVASCULAR-DISEASE; LIFE-COURSE ORIGINS;
   DIABETES-MELLITUS; SOCIAL INEQUALITIES; CENTRAL OBESITY; YOUNG-ADULTS;
   DEPRESSION
AB Objective: The objective of this study was to examine the association of individual socioeconomic status (iSES) and neighborhood SES (nSES) on the prevalence of metabolic syndrome (MetS) in the Atherosclerosis Risk in Communities Study (1987-1999). Methods: Participants included 2932 black and 9777 white men and women aged 45 to 64 years without diabetes at baseline. Total combined family income for the past 12 months and six census tract socioeconomic measures combined into a composite index were used to quantify iSES and nSES, respectively. Poisson regression was used to assess associations of the joint contribution of iSES and nSES on the MetS, stratified by gender and race and adjusting for multiple covariates. For analyses that included nSES, hierarchical modeling techniques were used. Results: Using 2005 Third Report of the Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults criteria, MetS was identified in 40% of black women, 30% of white women, 28% of black men, and 35% of white men. Among black and white men, there was no association between MetS and iSES or nSES. In contrast, after adjustment for risk factors, black and white women with low (L)-iSES and medium (M)-iSES were more likely to have MetS than those with high (H)-iSES. Similar but weaker patterns were noted for L-nSES and M-nSES. Conclusions: In summary, both iSES and nSES were independently associated with an increased prevalence of MetS among women but not men. Efforts aimed at understanding the causes of these gender differences may offer insight into avenues for reducing the prevalence of the MetS and its chronic disease sequelae.
C1 [Chichlowska, Kristal L.; Rose, Kathryn M.; Heiss, Gerardo] Univ N Carolina, Sch Publ Hlth, Dept Epidemiol, Chapel Hill, NC USA.
   [Diez-Roux, Ana V.] Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA.
   [Golden, Sherita H.] Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21205 USA.
   [McNeill, Annie M.] Merck & Co Inc, N Wales, PA USA.
C3 University of North Carolina; University of North Carolina Chapel Hill;
   University of Michigan System; University of Michigan; Johns Hopkins
   University; Merck & Company; Merck & Company USA
RP Chichlowska, KL (corresponding author), Bank Amer Ctr, 137 E Franklin St,Ste 306, Chapel Hill, NC 27514 USA.
EM raymon@email.unc.edu
FU National Heart, Lung and Blood Institute [1R01HL080287, N01-55015,
   N01-55016, N01-55018, N01-55019, N01-55020, N01-55021, N01-55022,
   R01-HL064142]
FX This research was supported by the National Heart, Lung and Blood
   Institute Grant No. 1R01HL080287 (to K.M.R.) and 1R01HL080287 to 01S1
   (to K.M.R, K.L.C.). The Atherosclerosis Risk in Communities Study is
   carried out as a collaborative study supported by contracts from the
   National Heart, Lung, and Blood Institute (N01-55015, N01-55016,
   N01-55018, N01-55019, N01-55020, N01-55021, N01-55022, and
   R01-HL064142).
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NR 76
TC 71
Z9 83
U1 0
U2 14
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0033-3174
EI 1534-7796
J9 PSYCHOSOM MED
JI Psychosom. Med.
PD NOV-DEC
PY 2008
VL 70
IS 9
BP 986
EP 992
DI 10.1097/PSY.0b013e318183a491
PG 7
WC Psychiatry; Psychology; Psychology, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry; Psychology
GA 375RE
UT WOS:000261130200005
PM 18799428
OA Green Submitted, Green Published, Green Accepted
DA 2025-06-11
ER

PT J
AU Zeman, M
   Jáchymová, M
   Jirák, R
   Vecka, M
   Tvrzická, E
   Stanková, B
   Zák, A
AF Zeman, M.
   Jachymova, M.
   Jirak, R.
   Vecka, M.
   Tvrzicka, E.
   Stankova, B.
   Zak, A.
TI Polymorphisms of Genes for Brain-Derived Neurotrophic Factor,
   Methylenetetrahydrofolate Reductase, Tyrosine Hydroxylase, and
   Endothelial Nitric Oxide Synthase in Depression and Metabolic Syndrome
SO FOLIA BIOLOGICA
LA English
DT Article
DE depression; metabolic syndrome; BDNF; gene polymorphism
ID BDNF VAL66MET POLYMORPHISM; CARDIOVASCULAR-DISEASE;
   ESSENTIAL-HYPERTENSION; REPEAT POLYMORPHISM; INSULIN-RESISTANCE; BIPOLAR
   DISORDER; MOOD DISORDERS; ASSOCIATION; VARIANT; EPIDEMIOLOGY
AB The prevalence of metabolic syndrome as well as the occurrence of depressive disorder, which are both connected with increased risk of diabetes mellitus type 2 and cardiovascular diseases, is continually increasing worldwide. These disorders are interconnected at various levels; the genetic one seems to be promising. Contribution of genetic factors to the aetiopathogenesis of depressive disorder weighs within the range 40-50 %, whereas the genetic background for the manifestation of metabolic syndrome is more complicated. In this pilot study, we investigated the incidence of polymorphisms in several genes supposed to play a role in the development of both depressive disorder and metabolic syndrome such as brain-derived neurotrophic factor, methylenetetrahydrofolate reductase, tyrosine hydroxylase, and endothelial nitric oxide synthase. The entire group consisted of 42 patients with depressive disorder, 57 probands with metabolic syndrome and 41 control individuals. We found that genotype Met/Met of the Val66Met polymorphism of the brain-derived neurotrophic factor gene was positively associated with depressive disorder (P < 0.05), but we were not able to find any significant associations of both the depressive disorder and metabolic syndrome with the remaining polymorphisms studied (methylenetetrahydrofolate reductase 677CT, methylenetetrahydrofolate reductase 1298AC, endothelial nitric oxide synthase Glu298Asp, and tyrosine hydroxylase).
C1 [Zeman, M.; Jirak, R.; Vecka, M.; Tvrzicka, E.; Stankova, B.; Zak, A.] Charles Univ Prague, Fac Med 1, Prague 12808 2, Czech Republic.
   [Zeman, M.; Vecka, M.; Tvrzicka, E.; Stankova, B.; Zak, A.] Charles Univ Prague, Gen Univ Hosp, Dept Internal Med 4, Prague 12808 2, Czech Republic.
   [Jirak, R.] Charles Univ Prague, Gen Univ Hosp, Psychiat Clin, Prague 12808 2, Czech Republic.
   [Jachymova, M.] Inst Clin Biochem & Lab Diagnost, Prague, Czech Republic.
C3 Charles University Prague; General University Hospital Prague; Charles
   University Prague; General University Hospital Prague; Charles
   University Prague
RP Zeman, M (corresponding author), Charles Univ Prague, Fac Med 1, Nemocnice 2, Prague 12808 2, Czech Republic.
EM mirozem@seznam.cz
RI Jirak, Roman/O-1658-2017; Zeman, Miroslav/J-5281-2016; Zak,
   Ales/G-8318-2016; Tvrzicka, Eva/Q-6300-2016; Stankova,
   Barbora/L-7933-2016; Vecka, Marek/A-3560-2008
OI Jirak, Roman/0000-0002-8061-9668; Zeman, Miroslav/0000-0001-5338-603X;
   Zak, Ales/0000-0002-1698-6068; Tvrzicka, Eva/0000-0003-0794-8454;
   Stankova, Barbora/0000-0002-6184-4878; Vecka, Marek/0000-0002-3269-1817
FU Internal Grant Agency of the Ministry of Health of the Czech Republic
   [NR 8806-3]; Ministry of Education, Youth and Sports of the Czech
   Republic [MSM 0021620820]
FX This work was supported by the research grant of the Internal Grant
   Agency of the Ministry of Health of the Czech Republic NR 8806-3, and by
   research project MSM 0021620820 of the Ministry of Education, Youth and
   Sports of the Czech Republic.
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NR 67
TC 27
Z9 29
U1 0
U2 7
PU CHARLES UNIV PRAGUE, FIRST FACULTY MEDICINE
PI PRAGUE 6
PA FLEMINGOVO NAM. 2, PRAGUE 6 166 37, CZECH REPUBLIC
SN 0015-5500
J9 FOLIA BIOL-PRAGUE
JI Folia Biol.-Prague
PY 2010
VL 56
IS 1
BP 19
EP 26
PG 8
WC Biochemistry & Molecular Biology; Biology; Oncology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Oncology; Cell Biology
GA 588LO
UT WOS:000277071800004
PM 20163778
DA 2025-06-11
ER

PT J
AU Pape, LM
   Adriaanse, MC
   Kol, J
   van Straten, A
   van Meijel, B
AF Pape, Laura M.
   Adriaanse, Marcel C.
   Kol, Jelle
   van Straten, Annemieke
   van Meijel, Berno
TI Patient-reported outcomes of lifestyle interventions in patients with
   severe mental illness: a systematic review and meta-analysis
SO BMC PSYCHIATRY
LA English
DT Review
DE Severe mental illness; Lifestyle intervention; Patient-reported outcome;
   Systematic review; Meta-analysis
ID RANDOMIZED CONTROLLED-TRIAL; QUALITY-OF-LIFE; MAJOR DEPRESSIVE DISORDER;
   FORM HEALTH SURVEY; WEIGHT-LOSS; PHYSICAL-ACTIVITY;
   CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; BIPOLAR DISORDER;
   SCHIZOPHRENIA
AB Background Lifestyle interventions for severe mental illness (SMI) are known to have small to modest effect on physical health outcomes. Little attention has been given to patient-reported outcomes (PROs). Aim To systematically review the use of PROs and their measures, and quantify the effects of lifestyle interventions in patients with SMI on these PROs. Methods Five electronic databases were searched (PubMed/Medline, Embase, PsycINFO, CINAHL, and Web of Science) from inception until 12 November 2020 (PROSPERO: CRD42020212135). Randomised controlled trials (RCTs) evaluating the efficacy of lifestyle interventions focusing on healthy diet, physical activity, or both for patients with SMI were included. Outcomes of interest were PROs. Results A total of 11.267 unique records were identified from the database search, 66 full-text articles were assessed, and 36 RCTs were included, of which 21 were suitable for meta-analyses. In total, 5.907 participants were included across studies. Lifestyle interventions had no significant effect on quality of life (g = 0.13; 95% CI = - 0.02 to 0.27), with high heterogeneity (I-2 = 68.7%). We found a small effect on depression severity (g = 0.30, 95% CI = 0.00 to 0.58, I-2 = 65.2%) and a moderate effect on anxiety severity (g = 0.56, 95% CI = 0.16 to 0.95, I-2 = 0%). Discussion This meta-analysis quantifies the effects of lifestyle interventions on PROs. Lifestyle interventions have no significant effect on quality of life, yet they could improve mental health outcomes such as depression and anxiety symptoms. Further use of patient-reported outcome measures in lifestyle research is recommended to fully capture the impact of lifestyle interventions.
C1 [Pape, Laura M.; Adriaanse, Marcel C.; Kol, Jelle] Vrije Univ, Dept Hlth Sci, Fac Sci, Amsterdam, Netherlands.
   [Pape, Laura M.; Adriaanse, Marcel C.; Kol, Jelle; van Straten, Annemieke] Vrije Univ, Amsterdam Publ Hlth Res Inst, Amsterdam, Netherlands.
   [van Straten, Annemieke] Vrije Univ, Dept Clin Neuro & Dev Psychol, Amsterdam, Netherlands.
   [van Meijel, Berno] Inholland Univ Appl Sci, Dept Hlth Sports & Welf, Res Grp Mental Hlth Nursing, Amsterdam, Netherlands.
   [van Meijel, Berno] Amsterdam Publ Hlth Res Inst, Dept Psychiat, Amsterdam UMC VUmc, Amsterdam, Netherlands.
   [van Meijel, Berno] Parnassia Acad, Parnassia Psychiat Inst, The Hague, Netherlands.
C3 Vrije Universiteit Amsterdam; Vrije Universiteit Amsterdam; Vrije
   Universiteit Amsterdam; Vrije Universiteit Amsterdam; Parnassia
   Psychiatric Institute
RP Pape, LM (corresponding author), Vrije Univ, Dept Hlth Sci, Fac Sci, Amsterdam, Netherlands.; Pape, LM (corresponding author), Vrije Univ, Amsterdam Publ Hlth Res Inst, Amsterdam, Netherlands.
EM laura.pape@vu.nl
RI Adriaanse, Marieke/AFQ-8371-2022; van Straten, Annemieke/P-8495-2019
OI van Straten, Annemieke/0000-0001-6875-2215; Adriaanse,
   Marcel/0000-0002-5085-6662
FU Netherlands Organization for Health Research and Development (ZonMw)
   [80-84300-98-72012]
FX This systematic review and meta-analysis was funded by a grant of the
   Netherlands Organization for Health Research and Development (ZonMw);
   grant number 80-84300-98-72012. The funder had no control over any
   methodological aspect of the study nor did they have any input on the
   conduct, data collection, analysis interpretation or publication of the
   study results.
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NR 82
TC 23
Z9 23
U1 1
U2 13
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-244X
J9 BMC PSYCHIATRY
JI BMC Psychiatry
PD APR 13
PY 2022
VL 22
IS 1
AR 261
DI 10.1186/s12888-022-03854-x
PG 27
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 0M8WT
UT WOS:000782429800003
PM 35418082
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Morales-Espinoza, EM
   Kostov, B
   Salami, DC
   Perez, ZH
   Rosalen, AP
   Molina, JO
   Gonzalez-de Paz, L
   Momblona, JMS
   Areu, JB
   Brito-Zerón, P
   Ramos-Casals, M
   Sisó-Almirall, A
AF Marianela Morales-Espinoza, Enma
   Kostov, Belchin
   Cararach Salami, Daniel
   Herreras Perez, Zoe
   Pereira Rosalen, Anna
   Ortiz Molina, Jacinto
   Gonzalez-de Paz, Luis
   Sotoca Momblona, Josep Miquel
   Benavent Areu, Jaume
   Brito-Zeron, Pilar
   Ramos-Casals, Manuel
   Siso-Almirall, Antoni
CA CPSGPC Study Grp
TI Complexity, comorbidity, and health care costs associated with chronic
   widespread pain in primary care
SO PAIN
LA English
DT Article
DE Chronic pain; Primary healthcare; Quality of life; Cardiovascular
   diseases; Comorbidity; Healthcare costs
ID CHRONIC MUSCULOSKELETAL PAIN; QUALITY-OF-LIFE; SPANISH VERSION; IMPACT
   QUESTIONNAIRE; GENERAL-POPULATION; METABOLIC SYNDROME; FIBROMYALGIA;
   PREVALENCE; RISK; EPIDEMIOLOGY
AB The objective was to estimate the prevalence of chronic widespread pain (CWP) and compare the quality-of-life (QoL), cardiovascular risk factors, comorbidity, complexity, and health costs with the reference population. A multicenter case-control study was conducted at 3 primary care centers in Barcelona between January and December 2012: 3048 randomized patients were evaluated for CWP according to the American College of Rheumatology definition. Questionnaires on pain, QoL, disability, fatigue, anxiety, depression, and sleep quality were administered. Cardiovascular risk and the Charlson index were calculated. We compared the complexity of cases and controls using Clinical Risk Groups, severity and annual direct and indirect health care costs. CWP criteria were found in 168 patients (92.3% women, prevalence 5.51% [95% confidence interval: 4.75%-6.38%]). Patients with CWP had worse QoL (34.2 vs 44.1, P < 0.001), and greater disability (1.04 vs 0.35; P < 0.001), anxiety (43.9% vs 13.3%; P < 0.001), depression (27% vs 5.8%; P < 0.001), sleep disturbances, obesity, sedentary lifestyle, high blood pressure, diabetes mellitus, and number of cardiovascular events (13.1% vs 4.8%; P = 0.028) and higher rates of complexity, severity, hospitalization, and mortality. Costs were (sic)3751 per year in patients with CWP vs (sic)1397 in controls (P < 0.001). In conclusion, the average patient with CWP has a worse QoL and a greater burden of mental health disorders and cardiovascular risk. The average annual cost associated with CWP is nearly 3 times higher than that of patients without CWP, controlling for other clinical factors. These findings have implications for disease management and budgetary considerations.
C1 [Marianela Morales-Espinoza, Enma; Kostov, Belchin; Cararach Salami, Daniel; Herreras Perez, Zoe; Pereira Rosalen, Anna; Ortiz Molina, Jacinto; Gonzalez-de Paz, Luis; Sotoca Momblona, Josep Miquel; Benavent Areu, Jaume; Siso-Almirall, Antoni] Univ Barcelona, Inst Invest Biomed August Pi & Sunyer IDIBAPS, Transversal Grp Res Primary Care, CAPS BE, Barcelona, Spain.
   [Brito-Zeron, Pilar; Ramos-Casals, Manuel] Hosp Clin Barcelona, Josep Font Lab Autoimmune Dis, Dept Autoimmune Dis, CELLEX IDIBAPS,ICMiD, Barcelona, Spain.
C3 University of Barcelona; Hospital Clinic de Barcelona; IDIBAPS;
   University of Barcelona; Hospital Clinic de Barcelona; IDIBAPS
RP Sisó-Almirall, A (corresponding author), CAP Les Corts, CAPS BE, C Mejia Lequerica S-N, Barcelona 08028, Spain.
RI Ramos-Casals, Manuel/IUQ-6082-2023
OI Gonzalez de Paz, Luis/0000-0002-4767-8121; Ramos-Casals,
   Manuel/0000-0001-5709-6734; Siso Almirall, Antoni/0000-0001-9832-2689;
   Kostov, Belchin/0000-0002-2126-3892; Herreras, Zoe/0000-0001-5181-4723
FU Grants La Marato de TV3 [071810]; Fondo de Investigaciones Sanitarias
   [1201009]; "Ajut per a la Recerca Josep Font" from Hospital
   Clinic-Barcelona; "Ajuts a la Recerca Beca Fi Residencia" from CAPSBE
FX Supported by Grants La Marato de TV3 (071810), Fondo de Investigaciones
   Sanitarias (1201009), "Ajut per a la Recerca Josep Font" from Hospital
   Clinic-Barcelona (PB-Z, 2012), and "Ajuts a la Recerca Beca Fi
   Residencia 2010 to 2011" from CAPSBE (EMM-E).
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NR 62
TC 38
Z9 40
U1 1
U2 13
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0304-3959
EI 1872-6623
J9 PAIN
JI Pain
PD APR
PY 2016
VL 157
IS 4
BP 818
EP 826
DI 10.1097/j.pain.0000000000000440
PG 9
WC Anesthesiology; Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Anesthesiology; Neurosciences & Neurology
GA DP1PJ
UT WOS:000378261600009
PM 26645546
DA 2025-06-11
ER

PT J
AU Ziaei, S
   Hasani, M
   Malekahmadi, M
   Daneshzad, E
   Kadkhodazadeh, K
   Heshmati, J
AF Ziaei, Somayeh
   Hasani, Motahareh
   Malekahmadi, Mahsa
   Daneshzad, Elnaz
   Kadkhodazadeh, Katayoun
   Heshmati, Javad
TI Effect of melatonin supplementation on cardiometabolic risk factors,
   oxidative stress and hormonal profile in PCOS patients: a systematic
   review and meta-analysis of randomized clinical trials
SO JOURNAL OF OVARIAN RESEARCH
LA English
DT Review
DE Melatonin; PCOS; Cardiometabolic risk factors; Hormones; Pregnancy
ID POLYCYSTIC-OVARY-SYNDROME; PRIMORDIAL FOLLICLE LOSS; GENE-EXPRESSION;
   ANTIOXIDANT; TNF; STEROIDOGENESIS; ACTIVATION; PATHWAYS; PREVENTS; CELLS
AB BackgroundTo investigate whether melatonin supplementation can enhance cardiometabolic risk factors, reduce oxidative stress, and improve hormonal and pregnancy-related factors in patients with PCOS.MethodsWe conducted a systematic search of PubMed/Medline, Scopus, and the Cochrane Library for articles published in English from inception to March 2023. We included randomized controlled trials (RCTs) on the use of melatonin for patients with polycystic ovary syndrome (PCOS). We performed a meta-analysis using a random-effects model and calculated the standardized mean differences (SMDs) and 95% confidence intervals (CIs).ResultsSix studies met the inclusion criteria. The result of meta-analysis indicated that melatonin intake significantly increase TAC levels (SMD: 0.87, 95% CI: 0.46, 1.28, I2 = 00.00%) and has no effect on FBS, insulin, HOMA-IR, TC, TG, HDL, LDL, MDA, hs-CRP, mFG, SHBG, total testosterone, and pregnancy rate in patients with PCOS compare to controls. The included trials did not report any adverse events.ConclusionMelatonin is a potential antioxidant that may prevent damage from oxidative stress in patients with PCOS. However, the clear effect of melatonin supplementation on cardiometabolic risk factors, hormonal outcomes, and pregnancy-related outcomes needs to be evaluated further in large populations and long-term RCTs.
   Melatonin supplementation increases total antioxidant capacity (TAC) levels in PCOS patients, suggesting its potential as an antioxidant therapyMeta-analysis reveals no significant impact of melatonin on cardiometabolic risk factors, hormonal levels, or pregnancy rate in PCOS patients compared to controlsMelatonin intake shows no adverse events in PCOS patients, indicating its safety for supplementationFurther large-scale and long-term randomized controlled trials are needed to determine the full effects of melatonin supplementation in PCOS patients
C1 [Ziaei, Somayeh] Kermanshah Univ Med Sci, Emam Reza Hosp, ICU Dept, Kermanshah, Iran.
   [Hasani, Motahareh] Golestan Univ Med Sci, Sch Hlth, Dept Nutr Sci, Gorgan, Iran.
   [Malekahmadi, Mahsa] Univ Tehran Med Sci, Imam Khomeini Hosp Complex, Tehran, Iran.
   [Daneshzad, Elnaz] Alborz Univ Med Sci, Noncommunicable Dis Res Ctr, Karaj, Iran.
   [Kadkhodazadeh, Katayoun] Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Cellular & Mol Nutr, Tehran, Iran.
   [Heshmati, Javad] Univ Ottawa, Heart Inst, Ottawa, ON, Canada.
C3 Kermanshah University of Medical Sciences; Golestan University of
   Medical Sciences; Tehran University of Medical Sciences; Alborz
   University of Medical Sciences; Tehran University of Medical Sciences;
   University of Ottawa; University of Ottawa Heart Institute
RP Kadkhodazadeh, K (corresponding author), Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Cellular & Mol Nutr, Tehran, Iran.
EM katayoun.ka@gmail.com
RI heshmati, javad/H-6812-2019; Daneshzad, Elnaz/O-3694-2018; Hasani,
   Motahareh/AAY-8608-2020; malekahmadi, mahsa/ABD-2352-2020
FX Not applicable.
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TC 7
Z9 7
U1 1
U2 2
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1757-2215
J9 J OVARIAN RES
JI J. Ovarian Res.
PD JUL 4
PY 2024
VL 17
IS 1
AR 138
DI 10.1186/s13048-024-01450-z
PG 10
WC Reproductive Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Reproductive Biology
GA XN2B2
UT WOS:001262288000001
PM 38965577
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Aschbacher, K
   Rodriguez-Fernandez, M
   van Wietmarschen, H
   Tomiyama, AJ
   Jain, S
   Epel, E
   Doyle, FJ
   van der Greef, J
AF Aschbacher, Kirstin
   Rodriguez-Fernandez, Maria
   van Wietmarschen, Herman
   Tomiyama, A. Janet
   Jain, Shamini
   Epel, Elissa
   Doyle, Francis J., III
   van der Greef, Jan
TI The hypothalamic-pituitary-adrenal-leptin axis and metabolic health: a
   systems approach to resilience, robustness and control
SO INTERFACE FOCUS
LA English
DT Article
DE psychological stress; obesity; metabolic syndrome; dynamic systems;
   stress-eating; robustness
ID BODY-FAT DISTRIBUTION; CORTISOL SECRETION; SENSITIVITY-ANALYSIS;
   OXIDATIVE STRESS; ALLOSTATIC LOAD; GLUCOCORTICOIDS; OBESITY;
   DEXAMETHASONE; INHIBITION; WEIGHT
AB Glucocorticoids contribute to obesity and metabolic syndrome; however, the mechanisms are unclear, and prognostic measures are unavailable. A systems level understanding of the hypothalamic-pituitary-adrenal (HPA)-leptin axis may reveal novel insights. Eighteen obese premenopausal women provided blood samples every 10 min over 24 h, which were assayed for cortisol, adrenocorticotropin releasing hormone (ACTH) and leptin. A published personalized HPA systems model was extended to incorporate leptin, yielding three parameters: (i) cortisol inhibitory feedback signalling, (ii) ACTH-adrenal signalling, and (iii) leptin-cortisol antagonism. We investigated associations between these parameters and metabolic risk profiles: fat and lean body mass (LBM; using dual-energy X-ray absorptiometry), and insulin resistance. Decreased cortisol inhibitory feedback signalling was significantly associated with greater fat (kg; p = 0.01) and insulin resistance (p = 0.03) but not LBM. Leptin significantly antagonized cortisol dynamics in eight women, who exhibited significantly lower 24 h mean leptin levels, LBM and higher ACTH-adrenal signalling nocturnally (all p < 0.05), compared with women without antagonism. Traditional neuroendocrine measures did not predict metabolic health, whereas a dynamic systems approach revealed that lower central inhibitory cortisol feedback signalling was significantly associated with greater metabolic risk. While exploratory, leptin-cortisol antagonism may reflect a 'neuroendocrine starvation' response.
C1 [Aschbacher, Kirstin; Epel, Elissa] Univ Calif San Francisco, Dept Psychiat, San Francisco, CA 94143 USA.
   [Aschbacher, Kirstin] Inst Integrat Hlth, Baltimore, MD USA.
   [Rodriguez-Fernandez, Maria; Doyle, Francis J., III] Univ Calif Santa Barbara, Dept Chem Engn, Santa Barbara, CA 93106 USA.
   [van Wietmarschen, Herman; van der Greef, Jan] TNO Innovat Life, Zeist, Netherlands.
   [van Wietmarschen, Herman; van der Greef, Jan] Leiden Univ, Dept Analyt Biosci, Leiden, Netherlands.
   [Tomiyama, A. Janet] Univ Calif Los Angeles, Dept Psychol, Los Angeles, CA 90024 USA.
   [Jain, Shamini] Samueli Inst, Dept Brain Mind & Healing, Alexandria, VA USA.
   [Jain, Shamini] Univ Calif San Diego, Dept Psychiat, San Diego, CA 92103 USA.
C3 University of California System; University of California San Francisco;
   University of California System; University of California Santa Barbara;
   Netherlands Organization Applied Science Research; Leiden University;
   Leiden University - Excl LUMC; University of California System;
   University of California Los Angeles; University of California System;
   University of California San Diego
RP Aschbacher, K (corresponding author), Univ Calif San Francisco, Dept Psychiat, San Francisco, CA 94143 USA.
EM kirstin.aschbacher@ucsf.edu
RI Epel, Elissa/ABI-6703-2022; van Wietmarschen, Herman/KBQ-4108-2024;
   Rodriguez-Fernandez, Maria/I-7193-2016
OI Doyle, Francis/0000-0001-5342-4083; Rodriguez-Fernandez,
   Maria/0000-0003-1966-2920; Aschbacher, Kirstin/0000-0001-6191-6432
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NR 71
TC 32
Z9 35
U1 0
U2 13
PU ROYAL SOC
PI LONDON
PA 6-9 CARLTON HOUSE TERRACE, LONDON SW1Y 5AG, ENGLAND
SN 2042-8898
EI 2042-8901
J9 INTERFACE FOCUS
JI Interface Focus
PD OCT 6
PY 2014
VL 4
IS 5
AR 20140020
DI 10.1098/rsfs.2014.0020
PG 9
WC Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics
GA AS8AM
UT WOS:000344472900005
PM 25285198
OA Green Published
DA 2025-06-11
ER

PT J
AU Souama, C
   Milaneschi, Y
   Lamers, F
   Vinkers, CH
   Giltay, EJ
   Liemburg, EJ
   Penninx, BWJH
AF Souama, Camille
   Milaneschi, Yuri
   Lamers, Femke
   Vinkers, Christiaan H.
   Giltay, Erik J.
   Liemburg, Edith J.
   Penninx, Brenda W. J. H.
TI Metabolic syndrome after childhood trauma: a 9-year longitudinal
   analysis
SO PSYCHOLOGICAL MEDICINE
LA English
DT Article
DE adverse childhood experiences; child abuse; childhood maltreatment;
   metabolic syndrome
ID CARDIOMETABOLIC DISEASE; PHYSICAL-ACTIVITY; USE DISORDERS; SEXUAL-ABUSE;
   RISK-FACTORS; LIFE EVENTS; ANXIETY; QUESTIONNAIRE; DEPRESSION;
   NETHERLANDS
AB Background. Childhood trauma (CT) has been cross-sectionally associated with metabolic syndrome (MetS), a group of biological risk factors for cardiometabolic disease. Longitudinal studies, while rare, would clarify the development of cardiometabolic dysregulations over time. Therefore, we longitudinally investigated the association of CT with the 9-year course of MetS components.
   Methods. Participants (N = 2958) from the Netherlands Study of Depression and Anxiety were assessed four times across 9 years. The CT interview retrospectively assessed childhood emotional neglect and physical, emotional, and sexual abuse. Metabolic outcomes encompassed continuous MetS components (waist circumference, triglycerides, high-density lipoprotein [HDL] cholesterol, blood pressure [BP], and glucose) and count of clinically elevated MetS components. Mixed-effects models estimated sociodemographic- and lifestyle-adjusted longitudinal associations of CT with metabolic outcomes over time. Time interactions evaluated change in these associations.
   Results. CT was reported by 49% of participants. CT was consistently associated with increased waist (b = 0.32, s.e. = 0.10, p = 0.001), glucose (b = 0.02, s.e. = 0.01, p < 0.001), and count of MetS components (b = 0.04, s.e. = 0.01, p < 0.001); and decreased HDL cholesterol (b = -0.01, s.e.<0.01, p = .020) and systolic BP (b = -0.33, s.e. = 0.13, p = 0.010). These associations were mainly driven by severe CT and unaffected by lifestyle. Only systolic BP showed a CT-by-time interaction, where CT was associated with lower systolic BP initially and with higher systolic BP at the last follow-up.
   Conclusions. Over time, adults with CT have overall persistent poorer metabolic outcomes than their non-maltreated peers. Individuals with CT have an increased risk for cardiometabolic disease and may benefit from monitoring and early interventions targeting metabolism.
C1 [Souama, Camille; Milaneschi, Yuri; Lamers, Femke; Vinkers, Christiaan H.; Penninx, Brenda W. J. H.] Locat Vrije Univ Amsterdam, Dept Psychiat, Amsterdam UMC, Boelelaan 1117, Amsterdam, Netherlands.
   [Souama, Camille; Milaneschi, Yuri; Lamers, Femke; Vinkers, Christiaan H.; Penninx, Brenda W. J. H.] Mental Hlth Program, Amsterdam Publ Hlth, Amsterdam, Netherlands.
   [Milaneschi, Yuri; Vinkers, Christiaan H.; Penninx, Brenda W. J. H.] Amsterdam Neurosci Mood Anxiety Psychosis Stress, Amsterdam, Netherlands.
   [Milaneschi, Yuri] Amsterdam Neurosci Complex Trait Genet, Amsterdam, Netherlands.
   [Vinkers, Christiaan H.] Iocat Vrije Univ Amsterdam, Dept Anat Neurosci, Amsterdam Univ Med Ctr, NL-1081 HV Amsterdam, Netherlands.
   [Vinkers, Christiaan H.] GGZ inGeest Mental Hlth Care, HJ Amsterdam, NL-1081 HJ Amsterdam, Netherlands.
   [Giltay, Erik J.] Leiden Univ Med Ctr, Dept Psychiat, Leiden, Netherlands.
   [Liemburg, Edith J.] Univ Groningen, Univ Med Ctr Groningen, Dept Psychiat, Rob Giel Res Ctr, Groningen, Netherlands.
C3 Leiden University; Leiden University Medical Center (LUMC); University
   of Groningen
RP Souama, C (corresponding author), Locat Vrije Univ Amsterdam, Dept Psychiat, Amsterdam UMC, Boelelaan 1117, Amsterdam, Netherlands.; Souama, C (corresponding author), Mental Hlth Program, Amsterdam Publ Hlth, Amsterdam, Netherlands.
EM c.p.souama@amsterdamumc.nl
RI Giltay, Erik/AAL-9948-2021; Lamers, Femke/G-5161-2012; Vinkers,
   Christiaan/AAV-1720-2020; Penninx, Brenda/S-7627-2017
OI Souama, Camille/0000-0001-5679-1436; Milaneschi,
   Yuri/0000-0002-3697-6617; Giltay, Erik J./0000-0001-8874-2292
FU European Union [848158]
FX This work is supported by the European Union's Horizon 2020 research and
   innovation program under grant agreement No 848158 (EarlyCause).
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NR 54
TC 6
Z9 6
U1 0
U2 5
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0033-2917
EI 1469-8978
J9 PSYCHOL MED
JI Psychol. Med.
PD MAY
PY 2024
VL 54
IS 7
BP 1373
EP 1381
DI 10.1017/S0033291723003264
PG 9
WC Psychology, Clinical; Psychiatry; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA 2XY2K
UT WOS:001493962600010
PM 37981868
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Fentie, D
   Derese, T
   Yazie, B
   Getachew, Y
AF Fentie, Dilnessa
   Derese, Tariku
   Yazie, Bekele
   Getachew, Yibeltal
TI Metabolic syndrome and associated factors among severely ill psychiatric
   and non-psychiatric patients: a comparative cross-sectional study in
   Eastern Ethiopia
SO DIABETOLOGY & METABOLIC SYNDROME
LA English
DT Article
DE Metabolic syndrome; Dilchora Hospital; Eastern Ethiopia; Psychiatric
   disorders
ID PREVALENCE; PATHOPHYSIOLOGY; MANAGEMENT
AB Plain language summary Metabolic syndrome is a risk factor for cardiovascular disease that has public health issues, which places social, economic, and disease conditions in the community within the geographical region of sub-Saharan Africa, including Ethiopia. Patients with psychiatric illness have a 2-threefold risk of morbidity and mortality from metabolic syndrome compared to the general population. Here, we look at range of the possible reasons psychiatric patients have less physical activity due to functional disorders or psychotropic medication, psychological stress, excessive alcohol intake, and inadequate medical care. We assessed the burden of metabolic syndrome and its components among psychiatric patients as compared to non-psychiatric individuals in Eastern Ethiopia for a period of 6 months. There has been an alarming increase in the burden of metabolic syndrome and its components among patients with psychiatric illness. Hence, our results allow readers to aware of the burden of metabolic syndrome and factors involved in the development of the syndrome among psychiatric clients.
   Background Metabolic syndrome is a major public health challenge in both developed and developing countries. The burden of this disease is high, even in patients with psychiatric disorders. However, very little is known about the association between metabolic syndrome and psychiatric illness in Ethiopia. Therefore, the aim of this study was to investigate the magnitude of metabolic syndrome and its components among psychiatric clients. Methods A comparative cross-sectional study was undertaken between psychiatric patients and age-and sex-matched non-psychiatric controls at the Dilchora referral hospital. The study included 192 study participants (96 psychiatric patients and 96 non- psychiatric controls from general medical and surgical patients). The National Cholesterol Education Program: Adult Treatment Panel III criteria were used to diagnose metabolic syndromes. The data were cleaned and analyzed using the Statistical Package for Social Sciences, Version 21. All intergroup comparisons for continuous data were performed using an independent sample t-test, whereas categorical data were analyzed using the Chi-square test. Logistic regression analysis was used to identify the association between metabolic syndrome and the associated variables. Results The magnitude of metabolic syndrome among psychiatric patients was 36.5% (95%CI: 27.6, 47.4) compared to non-psychiatric control patients, 21.9% (95%CI: 13.5, 30.3), p = 0.02. The prevalence of MetS components, such as waist circumference (25.0% vs. 14.3%), lower-high density lipoprotein level (35.4% vs. 20.8%), higher systolic blood pressure (41.7% vs. 29.2%) and higher fasting blood glucose (40.6% vs. 18.8%) showed statistically significant differences between the exposed and non-exposed groups. Age greater than 50 years (AOR: 2.8, CI: 1.14, 20.0, p < 0.05); being female (AOR: 7.4, CI: 2.0, 27.6, p < 0.05), being urban residence (AOR: 6.4, CI: 2.2, 20.6, p < 0.05), ever alcohol intake (AOR: 5.3, CI: 1.3, 21.2), being physically inactive (AOR: 3.52, CI: 1.1, 12.9, p < 0.05) and family history of hypertension (AOR: 2.52, CI: 1.1, 12.2, p < 0.05) were independent predictors of metabolic syndrome (p < 0.05). Conclusions There is a high burden of metabolic syndrome and its components in patients with severe psychiatric disorders. Therefore, screening and mitigation strategies for metabolic syndrome and their components should be implemented in the management of psychiatric disorders.
C1 [Fentie, Dilnessa; Yazie, Bekele] Dire Dawa Univ, Coll Med & Hlth Sci, Sch Med, POB 1362, Dire Dawa, Ethiopia.
   [Derese, Tariku] Dire Dawa Univ, Coll Med & Hlth Sci, Dept Publ Hlth, Dire Dawa, Ethiopia.
   [Getachew, Yibeltal] Dire Dawa Univ, Coll Med & Hlth Sci, Dept Psychiat, Dire Dawa, Ethiopia.
C3 University of Gondar; University of Gondar; University of Gondar
RP Fentie, D (corresponding author), Dire Dawa Univ, Coll Med & Hlth Sci, Sch Med, POB 1362, Dire Dawa, Ethiopia.
EM fagitaabo@gmail.com
OI Derese, Tariku/0000-0001-5305-7527; Yazie, Bekele/0009-0005-0443-1726;
   Getachew, Yibeltal/0000-0002-1284-8063
FU Dire Dawa University
FX T We are grateful to Dire Dawa University for its support and funding.
   We would like to thank all study participants, Dilchora psychiatric and
   regional laboratory staff for their contributions that have made this
   study possible.
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NR 56
TC 3
Z9 3
U1 1
U2 2
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1758-5996
J9 DIABETOL METAB SYNDR
JI Diabetol. Metab. Syndr.
PD NOV 10
PY 2021
VL 13
IS 1
AR 130
DI 10.1186/s13098-021-00750-4
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA WV0LL
UT WOS:000716927800001
PM 34758878
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Kinsky, S
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   Hawk, Mary
   Markovic, Nina
TI Risk of the Metabolic Syndrome in Sexual Minority Women: Results from
   the ESTHER Study
SO JOURNAL OF WOMENS HEALTH
LA English
DT Article
ID 3RD NATIONAL-HEALTH; DRINKING PATTERNS; ALL-CAUSE; ORIENTATION;
   POPULATION; DISPARITIES; DEPRESSION; OBESITY; GENDER; PREVALENCE
AB Objective: Compared to heterosexuals, sexual minority women (SMW) have higher rates of the metabolic syndrome risk factors (e.g., obesity, smoking, heavy drinking, and depression). Yet, no published research has examined whether SMW have higher rates of the metabolic syndrome. The aim of this study is to describe the prevalence of the metabolic syndrome and its individual factors in a sample of heterosexuals and SMW, and identify whether SMW are at greater risk of having the metabolic syndrome.
   Materials and Methods: Data are from the Epidemiologic STudy of HEalth Risk in Women (ESTHER), a cross-sectional convenience sample of 479 SMW and 400 heterosexual women from Pittsburgh, Pennsylvania. Participants provided self-report questionnaire data, clinical data, and blood work.
   Results: Compared to heterosexuals, SMW had higher mean waist circumference, fasting glucose, and systolic and diastolic blood pressure. Nearly one-quarter (24.3%) of SMW had the metabolic syndrome compared to 15.6% of heterosexual women (p = 0.002). After controlling for demographic and risk factors, SMW had a 44% higher risk of having the metabolic syndrome than heterosexuals (p = 0.031).
   Conclusions: To our knowledge, this is the first study to identify this health disparity in SMW. Future studies should explore differential risk of mortality and metabolic health between SMW and heterosexuals.
C1 [Kinsky, Suzanne; Stall, Ron; Hawk, Mary] Univ Pittsburgh, Grad Sch Publ Hlth, Dept Behav & Community Hlth Sci, Pittsburgh, PA USA.
   [Markovic, Nina] Univ Pittsburgh, Sch Dent Med, Dept Publ Hlth, Pittsburgh, PA USA.
   [Kinsky, Suzanne] UPMC Ctr High Value Hlth Care, US Steel Bldg,40th Floor,600 Grant St, Pittsburgh, PA 15219 USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE); University
   of Pittsburgh; Pennsylvania Commonwealth System of Higher Education
   (PCSHE); University of Pittsburgh
RP Kinsky, S (corresponding author), UPMC Ctr High Value Hlth Care, US Steel Bldg,40th Floor,600 Grant St, Pittsburgh, PA 15219 USA.
EM smk119@pitt.edu
OI Hawk, Mary/0000-0001-9753-4356; Kinsky, Suzanne/0000-0001-6957-2566
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NR 44
TC 19
Z9 21
U1 0
U2 8
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-9996
EI 1931-843X
J9 J WOMENS HEALTH
JI J. Womens Health
PD AUG
PY 2016
VL 25
IS 8
BP 784
EP 790
DI 10.1089/jwh.2015.5496
PG 7
WC Public, Environmental & Occupational Health; Medicine, General &
   Internal; Obstetrics & Gynecology; Women's Studies
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; General & Internal
   Medicine; Obstetrics & Gynecology; Women's Studies
GA DS5GE
UT WOS:000380808600004
PM 26885574
OA Green Published
DA 2025-06-11
ER

PT J
AU Bartosiewicz, A
   Luszczki, E
   Nagórska, M
   Oleksy, L
   Stolarczyk, A
   Deren, K
AF Bartosiewicz, Anna
   Luszczki, Edyta
   Nagorska, Malgorzata
   Oleksy, Lukasz
   Stolarczyk, Artur
   Deren, Katarzyna
TI Risk Factors of Metabolic Syndrome among Polish Nurses
SO METABOLITES
LA English
DT Article
DE metabolic syndrome; cardiovascular diseases; health behaviors; obesity;
   nurses; risk factor
ID UNITED-STATES; OBESITY; HEALTH; PREVALENCE; CARE; STRESS; ASSOCIATION;
   POPULATION; DISEASE; DYSLIPIDEMIA
AB The metabolic syndrome, also known as syndrome X or the insulin resistance, is defined by the World Health Organization as a pathologic condition characterized by abdominal obesity, insulin resistance, hypertension, and hyperlipidemia. Both all over the world and in Poland, there is a shortage of nurses; most of those employed are in the pre-retirement age. However, the requirements in this profession and the patient's right to care at the highest level remain unchanged and do not take into account the poor condition or age of working nurses, so special attention should be paid to the state of health in this professional group. There is an emphasis on the importance of the adopted attitude toward health and the resulting behaviors, such as regular weight control, following dietary recommendations, regular physical activity and participation in preventive examinations. The aim of the study was to assess the frequency of the occurrence of the metabolic syndrome, its individual components and determining the factors influencing its development in Polish nurses. The research conducted among the nurses in question included DXA (Dual Energy X-ray Absorptiometry) measurements, assessment of glucose concentration, lipid profile, blood pressure and a questionnaire survey. Almost half of the surveyed nurses have metabolic syndrome, which significantly increases the risk of developing cardiovascular diseases or diabetes. After multivariate analysis, it was found that being overweight and obesity were significant factors influenced the MS (metabolic syndrome) occurrence among Polish nurses. Being overweight increases the chances of MS occurrence 8.58 times in relation to BMI (Body Mass Index) <25, obesity increases the chances of MS occurrence 8.085 times in relation to BMI <25, and obesity class II/III increases the chances of MS occurrence 16.505 times in relation to BMI <25. Preventive and supportive measures for this professional group are needed.
C1 [Bartosiewicz, Anna; Luszczki, Edyta; Deren, Katarzyna] Med Coll Rzeszow Univ, Inst Hlth Sci, PL-35959 Rzeszow, Poland.
   [Nagorska, Malgorzata] Med Coll Rzeszow Univ, Inst Med Sci, PL-35959 Rzeszow, Poland.
   [Oleksy, Lukasz; Stolarczyk, Artur] Med Univ Warsaw, Orthopaed & Rehabil Dept, PL-02091 Warsaw, Poland.
C3 Medical University of Warsaw
RP Bartosiewicz, A (corresponding author), Med Coll Rzeszow Univ, Inst Hlth Sci, PL-35959 Rzeszow, Poland.
EM abartosiewicz@ur.edu.pl; eluszczki@ur.edu.pl; nagorska@ur.edu.pl;
   loleksy@oleksy-fizjoterapia.pl; artur.stolarczyk@wum.edu.pl;
   kderen@ur.edu.pl
RI Stolarczyk, Artur/AAA-1401-2021; Łuszczki, Edyta/AAP-1883-2020;
   Bartosiewicz, Anna/K-9621-2019; Dereń, Katarzyna/AAA-8916-2019;
   Nagórska, Małgorzata/ABF-1477-2020; Oleksy, Łukasz/AAQ-1244-2021
OI Deren, Katarzyna/0000-0002-0977-5844; Luszczki,
   Edyta/0000-0002-4619-7705; Stolarczyk, Artur/0000-0002-5633-8153;
   Bartosiewicz, Anna/0000-0003-2359-7818; Oleksy,
   Lukasz/0000-0002-0589-0554; Nagorska, Malgorzata/0000-0002-3229-1186
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NR 79
TC 8
Z9 8
U1 1
U2 9
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2218-1989
J9 METABOLITES
JI Metabolites
PD MAY
PY 2021
VL 11
IS 5
AR 267
DI 10.3390/metabo11050267
PG 19
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Biochemistry & Molecular Biology
GA SH7BX
UT WOS:000654290300001
PM 33922860
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Ditmars, HL
   Logue, MW
   Toomey, R
   McKenzie, RE
   Franz, CE
   Panizzon, MS
   Reynolds, CA
   Cuthbert, KN
   Vandiver, R
   Gustavson, DE
   Eglit, GML
   Elman, JA
   Sanderson-Cimino, M
   Williams, ME
   Andreassen, OA
   Dale, AM
   Eyler, LT
   Fennema-Notestine, C
   Gillespie, NA
   Hauger, RL
   Jak, AJ
   Neale, MC
   Tu, XM
   Whitsel, N
   Xian, H
   Kremen, WS
   Lyons, MJ
AF Ditmars, Hillary L.
   Logue, Mark W.
   Toomey, Rosemary
   McKenzie, Ruth E.
   Franz, Carol E.
   Panizzon, Matthew S.
   Reynolds, Chandra A.
   Cuthbert, Kristy N.
   Vandiver, Richard
   Gustavson, Daniel E.
   Eglit, Graham M. L.
   Elman, Jeremy A.
   Sanderson-Cimino, Mark
   Williams, McKenna E.
   Andreassen, Ole A.
   Dale, Anders M.
   Eyler, Lisa T.
   Fennema-Notestine, Christine
   Gillespie, Nathan A.
   Hauger, Richard L.
   Jak, Amy J.
   Neale, Michael C.
   Tu, Xin M.
   Whitsel, Nathan
   Xian, Hong
   Kremen, William S.
   Lyons, Michael J.
TI Associations between depression and cardiometabolic health: A 27-year
   longitudinal study
SO PSYCHOLOGICAL MEDICINE
LA English
DT Article
DE Depression; Cardiometabolic health; Polygenic risk scores
ID GENOME-WIDE ASSOCIATION; CORONARY-ARTERY-DISEASE; OBSTRUCTIVE
   SLEEP-APNEA; FALSE DISCOVERY RATE; VIETNAM ERA TWIN; MENTAL-HEALTH;
   HEART-DISEASE; RISK; IMPACT; INFLAMMATION
AB Background Clarifying the relationship between depression symptoms and cardiometabolic and related health could clarify risk factors and treatment targets. The objective of this study was to assess whether depression symptoms in midlife are associated with the subsequent onset of cardiometabolic health problems. Methods The study sample comprised 787 male twin veterans with polygenic risk score data who participated in the Harvard Twin Study of Substance Abuse ('baseline') and the longitudinal Vietnam Era Twin Study of Aging ('follow-up'). Depression symptoms were assessed at baseline [mean age 41.42 years (s.d. = 2.34)] using the Diagnostic Interview Schedule, Version III, Revised. The onset of eight cardiometabolic conditions (atrial fibrillation, diabetes, erectile dysfunction, hypercholesterolemia, hypertension, myocardial infarction, sleep apnea, and stroke) was assessed via self-reported doctor diagnosis at follow-up [mean age 67.59 years (s.d. = 2.41)]. Results Total depression symptoms were longitudinally associated with incident diabetes (OR 1.29, 95% CI 1.07-1.57), erectile dysfunction (OR 1.32, 95% CI 1.10-1.59), hypercholesterolemia (OR 1.26, 95% CI 1.04-1.53), and sleep apnea (OR 1.40, 95% CI 1.13-1.74) over 27 years after controlling for age, alcohol consumption, smoking, body mass index, C-reactive protein, and polygenic risk for specific health conditions. In sensitivity analyses that excluded somatic depression symptoms, only the association with sleep apnea remained significant (OR 1.32, 95% CI 1.09-1.60). Conclusions A history of depression symptoms by early midlife is associated with an elevated risk for subsequent development of several self-reported health conditions. When isolated, non-somatic depression symptoms are associated with incident self-reported sleep apnea. Depression symptom history may be a predictor or marker of cardiometabolic risk over decades.
C1 [Ditmars, Hillary L.; Toomey, Rosemary; McKenzie, Ruth E.; Cuthbert, Kristy N.; Vandiver, Richard; Lyons, Michael J.] Boston Univ, Dept Psychol & Brain Sci, Boston, MA 02215 USA.
   [Logue, Mark W.] VA Boston Healthcare Syst, Res Serv, Boston, MA USA.
   [Logue, Mark W.] Boston Univ, Sch Med, Biomed Genet Program, Boston, MA 02118 USA.
   [Logue, Mark W.] Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA USA.
   [McKenzie, Ruth E.] Merrimack Coll, Sch Educ & Social Policy, N Andover, MA 01845 USA.
   [Franz, Carol E.; Panizzon, Matthew S.; Eglit, Graham M. L.; Elman, Jeremy A.; Sanderson-Cimino, Mark; Williams, McKenna E.; Eyler, Lisa T.; Fennema-Notestine, Christine; Hauger, Richard L.; Jak, Amy J.; Whitsel, Nathan; Kremen, William S.] Univ Calif San Diego, Sch Med, Dept Psychiat, 9500 Gillman Dr, La Jolla, CA 92093 USA.
   [Franz, Carol E.; Panizzon, Matthew S.; Eglit, Graham M. L.; Elman, Jeremy A.; Hauger, Richard L.; Kremen, William S.] Univ Calif San Diego, Ctr Behav Genet Aging, La Jolla, CA 92093 USA.
   [Reynolds, Chandra A.] Univ Calif Riverside, Dept Psychol, Riverside, CA 92521 USA.
   [Gustavson, Daniel E.] Vanderbilt Univ, Med Ctr, Dept Med, Nashville, TN USA.
   [Eglit, Graham M. L.] VA San Diego Healthcare Syst, San Diego, CA USA.
   [Sanderson-Cimino, Mark; Williams, McKenna E.] San Diego State Univ, UC San Diego Joint Doctoral Program Clin Psychol, San Diego, CA 92182 USA.
   [Andreassen, Ole A.] Inst Clin Med Univ Oslo, KG Jebsen Ctr Psychosis Res, NORMENT, Oslo, Norway.
   [Andreassen, Ole A.] Oslo Univ Hosp, Div Mental Hlth & Addict, Oslo, Norway.
   [Dale, Anders M.; Fennema-Notestine, Christine] Univ Calif San Diego, Sch Med, Dept Radiol, La Jolla, CA 92093 USA.
   [Dale, Anders M.] Univ Calif San Diego, Dept Neurosci, La Jolla, CA 92093 USA.
   [Gillespie, Nathan A.; Neale, Michael C.] Virginia Commonwealth Univ, Virginia Inst Psychiat & Behav Genet, Dept Psychiat, Richmond, VA USA.
   [Hauger, Richard L.; Jak, Amy J.; Kremen, William S.] VA San Diego Healthcare Syst, Ctr Excellence Stress & Mental Hlth, San Diego, CA USA.
   [Neale, Michael C.] Virginia Commonwealth Univ, Virginia Inst Psychiat & Behav Genet, Dept Human & Mol Genet, Richmond, VA USA.
   [Tu, Xin M.] VA San Diego Healthcare Syst, Dept Family Med & Publ Hlth, San Diego, CA USA.
   [Xian, Hong] St Louis Univ, Coll Publ Hlth & Social Justice, Dept Epidemiol & Biostat, St Louis, MO 63103 USA.
C3 Boston University; Harvard University; Harvard University Medical
   Affiliates; US Department of Veterans Affairs; Veterans Health
   Administration (VHA); VA Boston Healthcare System; Boston University;
   Boston University; Merrimack College; University of California System;
   University of California San Diego; University of California System;
   University of California San Diego; University of California System;
   University of California Riverside; Vanderbilt University; US Department
   of Veterans Affairs; Veterans Health Administration (VHA); VA San Diego
   Healthcare System; California State University System; San Diego State
   University; University of Oslo; University of California System;
   University of California San Diego; University of California System;
   University of California San Diego; Virginia Commonwealth University; US
   Department of Veterans Affairs; Veterans Health Administration (VHA); VA
   San Diego Healthcare System; Virginia Commonwealth University; US
   Department of Veterans Affairs; Veterans Health Administration (VHA); VA
   San Diego Healthcare System; Saint Louis University
RP Ditmars, HL (corresponding author), Boston Univ, Dept Psychol & Brain Sci, Boston, MA 02215 USA.
EM hditmars@bu.edu
RI Andreassen, Ole/AFI-3767-2022; Fennema-Notestine,
   Christine/ABF-8153-2022; Reynolds, Chandra/AAH-2886-2020; Eyler,
   Lisa/AAQ-4337-2021; Neale, Michael/AAD-5056-2020; Cuthbert,
   Kristy/LKK-4467-2024
OI Ditmars, Hillary/0000-0002-5066-9103; Cuthbert,
   Kristy/0000-0003-2663-0388
FU National Institute on Aging [R01 AG050595, R01 AG022381, R01 AG022982,
   R01 AG059329, P01 AG055367, R56 AG037985]; Research Council of Norway
   [223273]; European Union [847776]; National Center for Advancing
   Translational Science [1KL2TR001444]; Virginia Center on Aging; National
   Institute on Aging [P01AG055367, R01AG059329, F31AG064834] Funding
   Source: NIH RePORTER
FX This work was supported by the National Institute on Aging (H.L.D.,
   M.W.L., R.T., R.E.M., C.E.F., M.S.P., K.N.C., R.V., D.E.G., M.S.-C.,
   M.E.W., N.A.G., M.C.N., X.M.T., N.W., H.X., W.S.K., and M.J.L., R01
   AG050595; R.E.M., C.E.F., W.S.K., and M.J.L., R01 AG022381; R.T.,
   R.E.M., W.S.K., and M.J.L., R01 AG022982; C.E.F and D.E.G., R01
   AG059329; C.E.F., P01 AG055367; C.E.F., R56 AG037985); the Research
   Council of Norway (O.A.A., 223273); the European Union's Horizon 2020
   Research and Innovation Action Grant (O.A.A., 847776); the National
   Center for Advancing Translational Science (J.A.E., 1KL2TR001444), and
   the Virginia Center on Aging (N.A.G.).
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NR 67
TC 25
Z9 26
U1 1
U2 8
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0033-2917
EI 1469-8978
J9 PSYCHOL MED
JI Psychol. Med.
PD OCT
PY 2022
VL 52
IS 14
BP 3007
EP 3017
AR PII S003329172000505X
DI 10.1017/S003329172000505X
EA JAN 2021
PG 11
WC Psychology, Clinical; Psychiatry; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA 6M4IT
UT WOS:000785635000001
PM 33431106
OA Green Submitted, Green Published, Green Accepted
DA 2025-06-11
ER

PT J
AU Hashemi, M
   Amin, MM
   Chavoshani, A
   Rafiei, N
   Ebrahimpour, K
   Kelishadi, R
AF Hashemi, Majid
   Amin, Mohammad Mehdi
   Chavoshani, Afsane
   Rafiei, Nasim
   Ebrahimpour, Karim
   Kelishadi, Roya
TI Relationship of Urinary Phthalate Metabolites with Cardiometabolic Risk
   Factors and Oxidative Stress Markers in Children and Adolescents
SO JOURNAL OF ENVIRONMENTAL AND PUBLIC HEALTH
LA English
DT Article
ID BISPHENOL-A; INSULIN-RESISTANCE; DNA-DAMAGE; NEW-YORK; EXPOSURE;
   ASSOCIATION; OBESITY; ESTERS; CHILDHOOD; TOXICITY
AB Introduction. Studies have proved that exposure of adults to phthalates might be related to cardiometabolic risk factors and changes in markers of oxidative stress. Such studies conducted on school-age children and adolescents are limited and fail to assess the simultaneous effect of phthalates on these risk factors and oxidative stress markers. Therefore, it was attempted to identify the relationship of urinary phthalate metabolites with cardiometabolic risk factors and oxidative stress markers in children and adolescents. Methods. In this cross-sectional study, 108 children and adolescents, living in Isfahan industrial city of Iran, were examined. Urine samples taken from the participants were analyzed for mono-butyl phthalate (MBP), mono-benzyl phthalate (MBzP), mono-(2-ethylhexyl) phthalate (MEHP), mono-(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP), mono-(2-ethyl-5-exohexyl) phthalate (MEOHP), and mono-methyl phthalate (MMP). Results. Results showed that, among phthalate metabolites, MBP had the highest concentration, followed by MBzP, MEOHP, MEHHP, MEHP, and MMP. Concentrations of these metabolites had a significant relationship with some of the cardiometabolic risk factors including systolic blood pressure (SBP), fasting blood sugar (FBS), and triglycerides (TG) (p < 0.05). Furthermore, the crude and adjusted linear regression models indicated the significant association of phthalate metabolites with superoxide dismutase (SOD), malondialdehyde (MDA), and homeostasis model assessment of insulin resistance (HOMA-IR) (p < 0.05). Conclusion. Although urinary phthalate concentrations could not exactly reflect the long-term exposure level in the studied age groups, the consumption of phthalate-free products during childhood and adolescent development shall be assumed helpful in maintaining a healthy lifestyle. To confirm these findings and develop effective intervention strategies, it would be necessary to perform longitudinal studies on diverse population.
C1 [Hashemi, Majid; Amin, Mohammad Mehdi; Chavoshani, Afsane; Rafiei, Nasim; Ebrahimpour, Karim] Isfahan Univ Med Sci, Sch Hlth, Dept Environm Hlth Engn, Esfahan, Iran.
   [Hashemi, Majid; Amin, Mohammad Mehdi; Chavoshani, Afsane; Rafiei, Nasim; Ebrahimpour, Karim] Isfahan Univ Med Sci, Res Inst Primordial Prevent Noncommunicable Dis, Environm Res Ctr, Esfahan, Iran.
   [Hashemi, Majid] Kerman Univ Med Sci, Sch Publ Hlth, Environm Hlth Engn, Kerman, Iran.
   [Hashemi, Majid] Kerman Univ Med Sci, Environm Hlth Engn Res Ctr, Kerman, Iran.
   [Kelishadi, Roya] Isfahan Univ Med Sci, Res Inst Primordial Prevent Noncommunicable Dis, Child Growth & Dev Res Ctr, Esfahan, Iran.
C3 Isfahan University of Medical Sciences; Isfahan University of Medical
   Sciences; Kerman University of Medical Sciences; Kerman University of
   Medical Sciences; Isfahan University of Medical Sciences
RP Amin, MM; Chavoshani, A (corresponding author), Isfahan Univ Med Sci, Sch Hlth, Dept Environm Hlth Engn, Esfahan, Iran.; Amin, MM; Chavoshani, A (corresponding author), Isfahan Univ Med Sci, Res Inst Primordial Prevent Noncommunicable Dis, Environm Res Ctr, Esfahan, Iran.
EM mhashemi120@gmail.com; mohammadmehdia@gmail.com;
   chavoshani.afsane@yahoo.com; nasim.rafiei@hlth.mui.ac.ir;
   k.ebrahiim@gmail.com; roya.kelishadi@gmail.com
RI Amin, Mohammad/A-1587-2018; Chavoshani, afsane/ABA-2859-2021;
   Ebrahimpour, Karim/A-4556-2018; rafiei, nasim/AAM-9697-2021; Kelishadi,
   Roya/E-6154-2012; Hashemi, Majid/C-6515-2018; Ebrahimpour,
   Karim/A-7180-2018
OI Hashemi, Majid/0000-0003-3254-2296; chavoshani,
   Afsane/0000-0002-5764-032X; Ebrahimpour, Karim/0000-0002-6230-0119
FU Isfahan University of Medical Sciences (IUMS), Iran
   [IR.MUI.REC.1394.3.984]
FX The authors wish to thank the Vice Chancellery of Research of Isfahan
   University of Medical Sciences (IUMS), Iran, for the financial support
   (ethics code: IR.MUI.REC.1394.3.984).
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NR 56
TC 21
Z9 21
U1 2
U2 15
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1687-9805
EI 1687-9813
J9 J ENVIRON PUBLIC HEA
JI J. Environ. Public Health
PD APR 27
PY 2021
VL 2021
AR 5514073
DI 10.1155/2021/5514073
PG 12
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA SX0ST
UT WOS:000664923500003
PM 33995534
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU BaHammam, AS
   Almeneessier, AS
AF BaHammam, Ahmed S.
   Almeneessier, Aljohara S.
TI Recent Evidence on the Impact of Ramadan Diurnal Intermittent Fasting,
   Mealtime, and Circadian Rhythm on Cardiometabolic Risk: A Review
SO FRONTIERS IN NUTRITION
LA English
DT Review
DE intermittent fasting; sleep; circadian rhythms; cardiometabolic disease;
   Ramadan; oxidative stress; proinflammatory markers
ID OXIDATIVE STRESS; CALORIC-INTAKE; WEIGHT-LOSS; ENERGY-EXPENDITURE;
   LIPID-PEROXIDATION; EATING PATTERNS; SLEEP; HEALTHY; TIME; MARKERS
AB In this article, we reviewed recent data that examined the relationship of circadian rhythm, mealtime, and intermittent fasting with the risk of cardiometabolic dysfunction. We also examined the effect of their interactions on cardiometabolic risks. Furthermore, since major differences exists between Ramadan diurnal intermittent fasting compared to other forms of experimental intermittent fasting, in this article, we further restricted the discussion to Ramadan diurnal intermittent fasting. PubMed and Google Scholar databases were searched using "intermittent fasting," "time-restricted feeding," "fasting," "mealtime," "circadian rhythm," and "cardiometabolic risk," focusing on human studies published after 2013. Recent evidence indicates that meal timing may influence circadian rhythm, as a result, it may also directly or indirectly impact cardiometabolic risk. In humans, several studies suggested that late mealtime is related to an increased risk of poor cardiometabolic health. Nevertheless, large clinical interventional studies are required to assess causality between late mealtime and cardiometabolic morbidity. Currently, evidence indicates that Ramadan diurnal intermittent fasting has several beneficial effects that may reduce the risk of cardiometabolic disorders, such as weight reduction, improvement in lipid profile and glycemic control, reduction in proinflammatory markers, and oxidative stress. Nevertheless, several changes in daily lifestyle routine, happening during the Ramadan month, may affect the all measured markers of cardiometabolic diseases. Summarily, no definitive conclusion about the impact of Ramadan intermittent fasting on oxidative stress can be formulated. Therefore, large, well-designed studies, which control for various confounding factors are required to assess the influence of Ramadan diurnal intermittent fasting on markers of cardiometabolic risk and disorders.
C1 [BaHammam, Ahmed S.; Almeneessier, Aljohara S.] King Saud Univ, Coll Med, Univ Sleep Disorders Ctr, Dept Med, Riyadh, Saudi Arabia.
   [Almeneessier, Aljohara S.] King Saud Univ, Dept Family Med, Coll Med, Riyadh, Saudi Arabia.
C3 King Saud University; King Saud University
RP BaHammam, AS (corresponding author), King Saud Univ, Coll Med, Univ Sleep Disorders Ctr, Dept Med, Riyadh, Saudi Arabia.
EM ashammam2@gmail.com
RI almeneessier, aljohara/ABA-3803-2021; BaHammam, Ahmed/B-9037-2008
OI almeneessier, aljohara/0000-0002-6298-1751; BaHammam,
   Ahmed/0000-0002-1706-6167
FU Strategic Technologies Program of the National Plan for Sciences and
   Technology and Innovation in the Kingdom of Saudi Arabia [08-MED511-02]
FX This study was funded by a grant from the Strategic Technologies Program
   of the National Plan for Sciences and Technology and Innovation in the
   Kingdom of Saudi Arabia (08-MED511-02).
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NR 97
TC 50
Z9 52
U1 1
U2 23
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD MAR 11
PY 2020
VL 7
AR 28
DI 10.3389/fnut.2020.00028
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA LC7SZ
UT WOS:000525534400001
PM 32219098
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Souama, C
   Milaneschi, Y
   Lamers, F
   Vinkers, CH
   Giltay, EJ
   Liemburg, EJ
   Penninx, BWJH
AF Souama, Camille
   Milaneschi, Yuri
   Lamers, Femke
   Vinkers, Christiaan H.
   Giltay, Erik J.
   Liemburg, Edith J.
   Penninx, Brenda W. J. H.
TI Metabolic syndrome after childhood trauma: a 9-year longitudinal
   analysis
SO PSYCHOLOGICAL MEDICINE
LA English
DT Article; Early Access
DE adverse childhood experiences; child abuse; childhood maltreatment;
   metabolic syndrome
ID CARDIOMETABOLIC DISEASE; PHYSICAL-ACTIVITY; USE DISORDERS; SEXUAL-ABUSE;
   RISK-FACTORS; LIFE EVENTS; ANXIETY; QUESTIONNAIRE; DEPRESSION;
   NETHERLANDS
AB Background Childhood trauma (CT) has been cross-sectionally associated with metabolic syndrome (MetS), a group of biological risk factors for cardiometabolic disease. Longitudinal studies, while rare, would clarify the development of cardiometabolic dysregulations over time. Therefore, we longitudinally investigated the association of CT with the 9-year course of MetS components.Methods Participants (N = 2958) from the Netherlands Study of Depression and Anxiety were assessed four times across 9 years. The CT interview retrospectively assessed childhood emotional neglect and physical, emotional, and sexual abuse. Metabolic outcomes encompassed continuous MetS components (waist circumference, triglycerides, high-density lipoprotein [HDL] cholesterol, blood pressure [BP], and glucose) and count of clinically elevated MetS components. Mixed-effects models estimated sociodemographic- and lifestyle-adjusted longitudinal associations of CT with metabolic outcomes over time. Time interactions evaluated change in these associations.Results CT was reported by 49% of participants. CT was consistently associated with increased waist (b = 0.32, s.e. = 0.10, p = 0.001), glucose (b = 0.02, s.e. = 0.01, p < 0.001), and count of MetS components (b = 0.04, s.e. = 0.01, p < 0.001); and decreased HDL cholesterol (b = -0.01, s.e.<0.01, p = .020) and systolic BP (b = -0.33, s.e. = 0.13, p = 0.010). These associations were mainly driven by severe CT and unaffected by lifestyle. Only systolic BP showed a CT-by-time interaction, where CT was associated with lower systolic BP initially and with higher systolic BP at the last follow-up.Conclusions Over time, adults with CT have overall persistent poorer metabolic outcomes than their non-maltreated peers. Individuals with CT have an increased risk for cardiometabolic disease and may benefit from monitoring and early interventions targeting metabolism.
C1 [Souama, Camille; Milaneschi, Yuri; Lamers, Femke; Vinkers, Christiaan H.; Penninx, Brenda W. J. H.] Locat Vrije Univ Amsterdam, Amsterdam UMC, Dept Psychiat, NL-1117 Amsterdam, Netherlands.
   [Souama, Camille; Milaneschi, Yuri; Lamers, Femke; Vinkers, Christiaan H.; Penninx, Brenda W. J. H.] Mental Hlth Program, Amsterdam Publ Hlth, Amsterdam, Netherlands.
   [Milaneschi, Yuri; Vinkers, Christiaan H.; Penninx, Brenda W. J. H.] Amsterdam Neurosci Mood Anxiety & Sleep Program, Amsterdam, Netherlands.
   [Milaneschi, Yuri] Amsterdam Neurosci, Complex Trait Genet, Amsterdam, Netherlands.
   [Vinkers, Christiaan H.] Locat Vrije Univ Amsterdam, Amsterdam Univ, Dept Anat & Neurosci, Med Ctr, NL-1081 HV Amsterdam, Netherlands.
   [Vinkers, Christiaan H.] GGZ inGeest Mental Hlth Care, NL-1081 HJ Amsterdam, Netherlands.
   [Giltay, Erik J.] Leiden Univ, Dept Psychiat, Med Ctr, Leiden, Netherlands.
   [Liemburg, Edith J.] Univ Groningen, Univ Med Ctr Groningen, Rob Giel Res Ctr, Dept Psychiat, Groningen, Netherlands.
C3 Vrije Universiteit Amsterdam; University of Amsterdam; Leiden
   University; Leiden University Medical Center (LUMC); Leiden University -
   Excl LUMC; University of Groningen
RP Souama, C (corresponding author), Locat Vrije Univ Amsterdam, Amsterdam UMC, Dept Psychiat, NL-1117 Amsterdam, Netherlands.; Souama, C (corresponding author), Mental Hlth Program, Amsterdam Publ Hlth, Amsterdam, Netherlands.
EM c.p.souama@amsterdamumc.nl
RI Giltay, Erik/AAL-9948-2021; Lamers, Femke/G-5161-2012; Vinkers,
   Christiaan/AAV-1720-2020; Penninx, Brenda/S-7627-2017
OI Souama, Camille/0000-0001-5679-1436; Milaneschi,
   Yuri/0000-0002-3697-6617; Giltay, Erik J./0000-0001-8874-2292
FU European Union [848158]
FX This work is supported by the European Union's Horizon 2020 research and
   innovation program under grant agreement No 848158 (EarlyCause).
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NR 54
TC 6
Z9 6
U1 0
U2 5
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0033-2917
EI 1469-8978
J9 PSYCHOL MED
JI Psychol. Med.
PD 2023 NOV 20
PY 2023
DI 10.1017/S0033291723003264
EA NOV 2023
PG 9
WC Psychology, Clinical; Psychiatry; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA Y6PR3
UT WOS:001106464900001
PM 37981868
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU La, SA
   Lee, JY
   Kim, DH
   Song, EL
   Park, JH
   Ju, SY
AF La, Sang A.
   Lee, June Young
   Kim, Do Hoon
   Song, E. Lang
   Park, Jin Hee
   Ju, Sang Yhun
TI Low Magnesium Levels in Adults with Metabolic Syndrome: a Meta-Analysis
SO BIOLOGICAL TRACE ELEMENT RESEARCH
LA English
DT Article
DE Magnesium; Trace elements; Serum; Hair; Mononuclear leukocytes;
   Metabolic syndrome X; Insulin resistance; Observational study;
   Meta-analysis
ID DIETARY MAGNESIUM; OXIDATIVE STRESS; HAIR; HYPOMAGNESEMIA; DEFICIENCY;
   OBESITY; WOMEN; MEN
AB There is conflicting evidence regarding the relationship between magnesium deficiency and metabolic syndrome, and a systematic assessment of the literature has not been performed. Our objective was to clarify the association between magnesium levels and metabolic syndrome by performing a meta-analysis. Based on 13 eligible studies involving 14 analyses and 5496 enrolled participants, magnesium levels were significantly lower in adults with metabolic syndrome than in controls (standardized mean difference [SMD] = -0.98, 95 % confidence interval [CI] = -1.44 to -0.52). There was marked heterogeneity when all comparisons were considered (I (2) = 98 %, p < 0.001). In the subgroup meta-analysis and meta-regression model, a significant difference in magnesium levels was noted by geographic location and study quality. Magnesium levels were lower in the experimental cases than in the controls in West Asia (SMD = -3.80, 95 % CI = -5.36, -2.23) and Latin America (SMD = -1.38, 95 % CI = -1.88, -0.87), but not in East Asia (SMD = -0.01, 95 % CI = -0.30, 0.29) or Europe/Oceania (SMD = -0.25, 95 % CI = -0.53, 0.03). Moreover, the inverse association was greater in high-quality studies (SMD = -2.52, 95 % CI = -3.72, -1.32) than in low-quality studies (SMD = -0.33, 95 % CI = -0.57, -0.08). In conclusion, although there was a high level of heterogeneity, this meta-analysis provided convincing evidence of reduced magnesium levels in adults with metabolic syndrome based on the findings of observational studies. However, the present findings should be validated by additional prospective studies or trans-regional multicenter randomized controlled trials, which generally yield higher-level evidence than case-control studies and cross-sectional studies.
C1 [La, Sang A.; Song, E. Lang; Ju, Sang Yhun] Catholic Univ Korea, Yeouido St Marys Hosp, Dept Family Med, Coll Med, 10,63 Ro, Seoul 150713, South Korea.
   [Lee, June Young] Korea Univ, Dept Biostat, Coll Med, Seongbuk Gul 136701, South Korea.
   [Kim, Do Hoon] Korea Univ, Ansan Hosp, Dept Family Med, Ansan 425707, Gyeonggi Do, South Korea.
   [Park, Jin Hee] Food & Drug Networking Co Ltd, Dept Res, Ctr Res & Dev, Seoul, South Korea.
C3 Catholic University of Korea; Korea University; Korea University
   Medicine (KU Medicine); Korea University; Korea University Medicine (KU
   Medicine)
RP Ju, SY (corresponding author), Catholic Univ Korea, Yeouido St Marys Hosp, Dept Family Med, Coll Med, 10,63 Ro, Seoul 150713, South Korea.
EM kolpos@daum.net
RI LEE, HYUN/D-6482-2016; Park, Jin/C-5307-2016; Ju, Sang/Q-2946-2019
OI Kim, Do Hoon/0000-0001-7421-4501; Lee, Juneyoung/0000-0001-8073-9304;
   Ju, Sang Yhun/0000-0002-0553-7128
FU Catholic Medical Center Research Foundation; Food and Drug Networking
   Co., Ltd.
FX We thank Kim, Na-Jin from the Medical Library, College of Medicine, The
   Catholic University of Korea, for performing database searches. This
   project was supported by a research grant from the Catholic Medical
   Center Research Foundation during the 2015 program year. Our study was
   partly supported by Food and Drug Networking Co., Ltd. The funding
   sources had no role in the study design, data collection and analysis,
   decision to publish, or preparation of the manuscript.
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NR 44
TC 24
Z9 26
U1 0
U2 16
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0163-4984
EI 1559-0720
J9 BIOL TRACE ELEM RES
JI Biol. Trace Elem. Res.
PD MAR
PY 2016
VL 170
IS 1
BP 33
EP 42
DI 10.1007/s12011-015-0446-9
PG 10
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA DD5CZ
UT WOS:000369941500005
PM 26208810
DA 2025-06-11
ER

PT J
AU Sil, R
   Chakraborti, AS
AF Sil, Rajarshi
   Chakraborti, Abhay Sankar
TI Oxidative Inactivation of Liver Mitochondria in High Fructose
   Diet-Induced Metabolic Syndrome in Rats: Effect of Glycyrrhizin
   Treatment
SO PHYTOTHERAPY RESEARCH
LA English
DT Article
DE metabolic syndrome; high fructose diet; oxidative stress; mitochondria;
   glycyrrhizin
ID CELL-DEATH; BRAIN MITOCHONDRIA; INSULIN-RESISTANCE; CARDIOLIPIN; STRESS;
   DAMAGE; ACID; PREVENTION; PROTECTION; DISEASE
AB Metabolic syndrome is a serious health problem in the present world. Glycyrrhizin, a triterpenoid saponin of licorice (Glycyrrhiza glabra) root, has been reported to ameliorate the primary complications and hepatocellular damage in rats with the syndrome. In this study, we have explored metabolic syndrome-induced changes in liver mitochondrial function and effect of glycyrrhizin against the changes. Metabolic syndrome was induced in rats by high fructose (60%) diet for 6 weeks. The rats were then treated with glycyrrhizin (50 mg/kg body weight) by single intra-peritoneal injection. After 2 weeks of the treatment, the rats were sacrificed to collect liver tissue. Elevated mitochondrial ROS, lipid peroxidation and protein carbonyl, and decreased reduced glutathione content indicated oxidative stress in metabolic syndrome. Loss of mitochondrial inner membrane cardiolipin was observed. Mitochondrial complex I activity did not change but complex IV activity decreased significantly. Mitochondrial MTT reduction ability, membrane potential, phosphate utilisation and oxygen consumption decreased in metabolic syndrome. Reduced mitochondrial aconitase activity and increased aconitase carbonyl content suggested oxidative damage of the enzyme. Elevated Fe2+ ion level in mitochondria might be associated with increased ROS generation in metabolic syndrome. Glycyrrhizin effectively attenuated mitochondrial oxidative stress and aconitase degradation, and improved electron transport chain activity. Copyright (C) 2016 John Wiley & Sons, Ltd.
C1 [Sil, Rajarshi; Chakraborti, Abhay Sankar] Univ Calcutta, Univ Coll Sci, Dept Biophys Mol Biol & Bioinformat, 92 Acharyya Prafulla Chandra Rd, Kolkata 700009, W Bengal, India.
   [Sil, Rajarshi] TIFR, Homi Bhabha Rd, Bombay 400005, Maharashtra, India.
C3 University of Calcutta; Tata Institute of Fundamental Research (TIFR)
RP Chakraborti, AS (corresponding author), Univ Calcutta, Univ Coll Sci, Dept Biophys Mol Biol & Bioinformat, 92 Acharyya Prafulla Chandra Rd, Kolkata 700009, W Bengal, India.
EM ascbmbg@caluniv.ac.in
FU University Grants Commission (UGC), India
FX R. S received research fellowship from University Grants Commission
   (UGC), India. Assistances from the Departmental Special Assistance
   Programme of UGC, Department of Science and Technology (DST-FIST
   programme) and Centre for Research in Nanoscience and Nanotechnology
   (CRNN), University of Calcutta, India are gratefully acknowledged.
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NR 47
TC 32
Z9 32
U1 0
U2 15
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0951-418X
EI 1099-1573
J9 PHYTOTHER RES
JI Phytother. Res.
PD SEP
PY 2016
VL 30
IS 9
BP 1503
EP 1512
DI 10.1002/ptr.5654
PG 10
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA DZ2VO
UT WOS:000385699900011
PM 27255442
DA 2025-06-11
ER

PT J
AU Kobrosly, RW
   van Wijngaarden, E
   Seplaki, CL
   Cory-Slechta, DA
   Moynihan, J
AF Kobrosly, Roni W.
   van Wijngaarden, Edwin
   Seplaki, Christopher L.
   Cory-Slechta, Deborah A.
   Moynihan, Jan
TI Depressive symptoms are associated with allostatic load among
   community-dwelling older adults
SO PHYSIOLOGY & BEHAVIOR
LA English
DT Article
DE Allostatic load; Depression; HPA axis
ID GROWTH-FACTOR-I; PHYSIOLOGICAL DYSREGULATION; LATE-LIFE; CES-D;
   METABOLIC SYNDROME; STRESS; RISK; REHABILITATION; VARIABILITY;
   PREDICTION
AB The allostatic load model has been used to quantify the physiological costs of the body's response to repeated stressful demands and may provide a useful, integrative perspective on the various correlates of late-life depressive symptoms. We interviewed 125 Rochester, NY adults, ranging in age from 67 to 94 years. We employed an allostatic load score as a measure of multisystem dysfunction in hypothalamic-pituitary-adrenal axis function, immune function, anabolic activity, and cardiovascular activity. Overall, affective, and somatic depressive symptom scores were computed using the 20-item Center for Epidemiologic Studies Depression Scale. Multiple linear regression models were used to estimate associations between allostatic load scores and affective, somatic, and overall depressive symptoms. Among our sample of mean age 76.1 years, the one-week prevalence of clinically significant depressive symptoms was 12.8%. In models adjusting for demographic, socioeconomic, and health-related factors, higher allostatic load scores were associated with elevated scores for overall, affective, and somatic depressive symptoms: beta = 121 (95% CI = 038, 2.05); beta = 0.14 (95% CI = 0.040, 0.24); beta = 0.60 (95% CI = 0.23, 0.97), respectively. Our results suggest that allostatic load measure is associated with late-life depressive symptoms. This association appears to be of clinical significance, as the magnitude of the effect size was comparable (but opposite in direction) to that of antidepressant use. Future research should examine the inter-relationships of allostatic load, psychological stress, and late-life depressive symptoms. (C) 2013 Elsevier Inc. All rights reserved.
C1 [Kobrosly, Roni W.; van Wijngaarden, Edwin; Seplaki, Christopher L.] Univ Rochester, Sch Med & Dent, Dept Publ Hlth Sci, Rochester, NY USA.
   [van Wijngaarden, Edwin; Cory-Slechta, Deborah A.] Univ Rochester, Sch Med & Dent, Dept Environm Med, Rochester, NY USA.
   [van Wijngaarden, Edwin] Univ Rochester, Sch Med & Dent, Dept Dent, Rochester, NY USA.
   [Moynihan, Jan] Univ Rochester, Sch Med & Dent, Dept Psychiat, Rochester, NY 14642 USA.
C3 University of Rochester; University of Rochester; University of
   Rochester; University of Rochester
RP Kobrosly, RW (corresponding author), Mt Sinai Sch Med, Dept Prevent Med, 1 Gustave L Levy Pl,Box 1057, New York, NY 10029 USA.
EM roni.kobrosly@mssm.edu
RI van Wijngaarden, Edwin/Q-2073-2019
OI van Wijngaarden, Edwin/0000-0001-7583-4630; Kobrosly,
   Roni/0000-0003-0363-9662; Seplaki, Christopher/0000-0001-8296-7714
FU National Center of Research Resources [UL1RR024160]; National Institute
   on Aging [K01AG031332];  [1R01AG025474]
FX The project described was supported by Award Number UL1RR024160 from the
   National Center of Research Resources and 1R01AG025474 (Moynihan). The
   content is solely the responsibility of the authors and does not
   necessarily represent the official views of the National Center for
   Research Resources or the National Institutes of Health.Dr. Seplaki is
   supported by Mentored Research Scientist Development Award number
   K01AG031332 from the National Institute on Aging. The content is solely
   the responsibility of the authors and does not necessarily represent the
   official views of the National Institute on Aging or the National
   Institutes of Health.
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NR 62
TC 58
Z9 74
U1 0
U2 16
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0031-9384
J9 PHYSIOL BEHAV
JI Physiol. Behav.
PD JAN 17
PY 2014
VL 123
BP 223
EP 230
DI 10.1016/j.physbeh.2013.10.014
PG 8
WC Psychology, Biological; Behavioral Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Behavioral Sciences
GA 293FJ
UT WOS:000329956500031
PM 24432360
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Organ, B
   Nicholson, E
   Castle, D
AF Organ, Bridget
   Nicholson, Emma
   Castle, David
TI Implementing a physical health strategy in a mental health service
SO AUSTRALASIAN PSYCHIATRY
LA English
DT Article
DE bipolar disorder; metabolic syndrome; monitoring; physical health;
   schizophrenia
ID METABOLIC RISK-ASSESSMENT; 2ND-GENERATION ANTIPSYCHOTICS; BARRIERS;
   CARE; SCHIZOPHRENIA
AB Objective: The aim of this paper is to describe a comprehensive metabolic monitoring strategy within an Australian public mental health service.
   Methods: Patient physical health was identified as a high priority within the mental health service. A survey of staff attitudes informed the development of metabolic monitoring guidelines and provision of education for clinicians and patients. An audit was subsequently performed to ascertain rates and results of metabolic monitoring, and focus groups helped to understand patient perspectives.
   Results: Despite significant barriers to the implementation of routine metabolic monitoring from both staff and patient perspectives, our programme delivered on around 60% coverage of routine monitoring of blood glucose and lipids and 54% on weight measurement. Compliance with measurement of waist circumference was much less (7%).
   Conclusions: To ensure adherence to metabolic monitoring programmes within mental health services, a comprehensive and multifaceted approach is required with ongoing education of both staff and patients.
C1 [Organ, Bridget; Nicholson, Emma; Castle, David] St Vincents Hosp, Melbourne, Vic, Australia.
   [Castle, David] Univ Melbourne, Melbourne, Vic, Australia.
C3 St Vincent's Health; St Vincent's Hospital Melbourne; NSW Health; St
   Vincents Hospital Sydney; University of Melbourne
RP Castle, D (corresponding author), Univ Melbourne, St Vincents Hosp, Level 2,46 Nicholson St, Fitzroy, Vic 3065, Australia.
EM david.castle@svhm.org.au
OI Castle, David/0000-0002-3075-1580
FU St Vincent's Research Grants Unit
FX We would like to acknowledge the St Vincent's Research & Grants Unit for
   funding this project and also Ms Katherine Fairest, RPN, for her work on
   the project.
CR Baker A, 2009, AUST NZ J PSYCHIAT, V43, P129, DOI 10.1080/00048670802607147
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NR 12
TC 40
Z9 41
U1 0
U2 7
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1039-8562
EI 1440-1665
J9 AUSTRALAS PSYCHIATRY
JI Australas. Psychiatry
PD OCT
PY 2010
VL 18
IS 5
BP 456
EP 459
DI 10.3109/10398562.2010.506217
PG 4
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 675HD
UT WOS:000283817400014
PM 20863187
DA 2025-06-11
ER

PT J
AU Tasaki, N
   Minematsu, T
   Mugita, Y
   Ikeda, S
   Nakagami, G
   Sanada, H
AF Tasaki, Natsumi
   Minematsu, Takeo
   Mugita, Yuko
   Ikeda, Shin-ichi
   Nakagami, Gojiro
   Sanada, Hiromi
TI Telogen elongation in the hair cycle of ob/ob mice
SO BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
LA English
DT Article
DE alopecia; hair cycle; metabolic syndrome; mouse
ID HUMAN SCALP EXPLANTS; ALOPECIA-AREATA; ANDROGENETIC ALOPECIA;
   MINERALOCORTICOID RECEPTOR; METABOLIC SYNDROME; OXIDATIVE STRESS; SKIN;
   MEN; WOMEN; ITCH
AB Alopecia impairs the physical and mental health of patients. We have previously shown that 8-week-old ob/ob mice have no reactivity to depilation, which is a stimulus that induces anagen transition in normal mice, while no hair cycle abnormalities have been reported in other studies until mice reach 7weeks of age. Therefore, we hypothesized that ob/ob mice have abnormalities in hair cycle progression beyond 7weeks of age. We examined 6- to 24-week-old ob/ob and 6- to 10-week-old normal mice. After acclimation, the dorsal skin was harvested and the hair cycle phase was identified histologically and immunohistochemically. Normal mice showed catagen-telogen and telogen-anagen transitions at 6 and 8-9weeks old, respectively. In contrast, the anagen-catagen transition was observed in 7-week-old mice and the telogen phase was maintained from 10 to 24weeks in most ob/ob mice. These results suggests that ob/ob mice are a possible model animal for telogen effluvium.
C1 [Tasaki, Natsumi; Minematsu, Takeo; Mugita, Yuko; Ikeda, Shin-ichi; Nakagami, Gojiro; Sanada, Hiromi] Univ Tokyo, Grad Sch Med, Dept Gerontol Nursing Wound Care Management, Tokyo, Japan.
C3 University of Tokyo
RP Sanada, H (corresponding author), Univ Tokyo, Grad Sch Med, Dept Gerontol Nursing Wound Care Management, Tokyo, Japan.
EM hsanada-tky@umin.ac.jp
RI Nakagami, Gojiro/V-9093-2019
OI Nakagami, Gojiro/0000-0002-9650-2464; Mugita, Yuko/0000-0003-4964-7107;
   Minematsu, Takeo/0000-0001-5859-7290
FU Grants-in-Aid for Scientific Research [25350901] Funding Source: KAKEN
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NR 42
TC 5
Z9 6
U1 0
U2 9
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0916-8451
EI 1347-6947
J9 BIOSCI BIOTECH BIOCH
JI Biosci. Biotechnol. Biochem.
PD JAN 2
PY 2016
VL 80
IS 1
BP 74
EP 79
DI 10.1080/09168451.2015.1069693
PG 6
WC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
   Chemistry, Applied; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
   Chemistry; Food Science & Technology
GA CX3VL
UT WOS:000365627500009
PM 26239026
OA Bronze
DA 2025-06-11
ER

PT J
AU Toenders, YJ
   Schmaal, L
   Nawijn, L
   Han, LKM
   Binnewies, J
   van der Wee, NJA
   van Tol, MJ
   Veltman, DJ
   Milaneschi, Y
   Lamers, F
   Penninx, BWJH
AF Toenders, Yara J.
   Schmaal, Lianne
   Nawijn, Laura
   Han, Laura K. M.
   Binnewies, Julia
   van der Wee, Nic J. A.
   van Tol, Marie-Jose
   Veltman, Dick J.
   Milaneschi, Yuri
   Lamers, Femke
   Penninx, Brenda W. J. H.
TI The association between clinical and biological characteristics of
   depression and structural brain alterations
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Major depressive disorder; Inflammation; Metabolic dysregulation; Brain
   structure
ID ANTERIOR CINGULATE CORTEX; MAJOR DEPRESSION; DISORDER; INFLAMMATION;
   SUBTYPES; DYSREGULATION; HETEROGENEITY; NETHERLANDS; REMISSION; FEATURES
AB Background: Structural brain alterations are observed in major depressive disorder (MDD). However, MDD is a highly heterogeneous disorder and specific clinical or biological characteristics of depression might relate to specific structural brain alterations. Clinical symptom subtypes of depression, as well as immuno-metabolic dysregulation associated with subtypes of depression, have been associated with brain alterations. Therefore, we examined if specific clinical and biological characteristics of depression show different brain alterations compared to overall depression. Method: Individuals with and without depressive and/or anxiety disorders from the Netherlands Study of Depression and Anxiety (NESDA) (328 participants from three timepoints leading to 541 observations) and the Mood Treatment with Antidepressants or Running (MOTAR) study (123 baseline participants) were included. Symptom profiles (atypical energy-related profile, melancholic profile and depression severity) and biological indices (inflammatory, metabolic syndrome, and immuno-metabolic indices) were created. The associations of the clinical and biological profiles with depression-related structural brain measures (anterior cingulate cortex [ACC], orbitofrontal cortex, insula, and nucleus accumbens) were examined dimensionally in both studies and meta-analysed. Results: Depression severity was negatively associated with rostral ACC thickness (B = -0.55, pFDR = 0.03), and melancholic symptoms were negatively associated with caudal ACC thickness (B = -0.42, pFDR = 0.03). The atypical energy-related symptom profile and immuno-metabolic indices did not show a consistent association with structural brain measures across studies. Conclusion: Overall depression- and melancholic symptom severity showed a dose-response relationship with reduced ACC thickness. No associations between immuno-metabolic dysregulation and structural brain alterations were found, suggesting that although both are associated with depression, distinct mechanisms may be involved.
C1 [Toenders, Yara J.; Schmaal, Lianne; Han, Laura K. M.] Orygen, Parkville, Australia.
   [Toenders, Yara J.; Schmaal, Lianne; Han, Laura K. M.] Univ Melbourne, Ctr Youth Mental Hlth, Parkville, Australia.
   [Nawijn, Laura; Binnewies, Julia; Veltman, Dick J.; Milaneschi, Yuri; Lamers, Femke; Penninx, Brenda W. J. H.] Vrije Univ Amsterdam, Dept Psychiat, Amsterdam UMC, Amsterdam Publ Hlth,Amsterdam Neurosci, Amsterdam, Netherlands.
   [Nawijn, Laura] Univ Amsterdam, Dept Psychiat, Amsterdam UMC, Amsterdam Publ Hlth,Amsterdam Neurosci, Amsterdam, Netherlands.
   [van der Wee, Nic J. A.] Leiden Univ Med Ctr, Dept Psychiat, Leiden, Netherlands.
   [van Tol, Marie-Jose] Univ Groningen, Univ Med Ctr Groningen, Dept Biomed Sci Cells & Syst, Groningen, Netherlands.
   [Toenders, Yara J.] Leiden Univ, Dept Dev & Educ Psychol, Leiden, Netherlands.
   [Toenders, Yara J.] Erasmus Univ, Erasmus Sch Social & Behav Sci, Rotterdam, Netherlands.
   [Toenders, Yara J.] Univ Melbourne, Ctr Youth Mental Hlth, Orygen, Parkville, Australia.
   [van der Wee, Nic J. A.] Leiden Univ Med Ctr, Leiden Inst Brain & Cognit, Leiden, Netherlands.
C3 Orygen, The National Centre of Excellence in Youth Mental Health;
   Orygen, The National Centre of Excellence in Youth Mental Health;
   University of Melbourne; Vrije Universiteit Amsterdam; University of
   Amsterdam; Vrije Universiteit Amsterdam; University of Amsterdam; Leiden
   University; Leiden University Medical Center (LUMC); University of
   Groningen; Leiden University; Leiden University - Excl LUMC; Erasmus
   University Rotterdam - Excl Erasmus MC; Erasmus University Rotterdam;
   University of Melbourne; Orygen, The National Centre of Excellence in
   Youth Mental Health; Leiden University; Leiden University Medical Center
   (LUMC)
RP Toenders, YJ (corresponding author), Univ Melbourne, Ctr Youth Mental Hlth, Orygen, Parkville, Australia.
EM y.j.toenders@fsw.leidenuniv.nl
RI Walter, Henrik/O-2612-2013; Han, Laura/AGV-3472-2022; Penninx,
   Brenda/S-7627-2017; Toenders, Yara/AAK-1956-2021; Nawijn,
   Laura/AAS-5912-2021; Lamers, Femke/G-5161-2012
OI Milaneschi, Yuri/0000-0002-3697-6617; van Tol,
   Marie-Jose/0000-0002-9260-5490; Han, Laura/0000-0001-9647-3723
FU Geestkracht program of the Netherlands Organization for Health Research
   and Development (ZonMw) [10-000-1002]; VU University Medical Center; GGZ
   inGeest; Arkin; Leiden University Medical Center; GGZ Rivierduinen;
   University Medical Center Groningen; Lentis; GGZ Friesland; GGZ Drenthe;
   Institute for Quality of Health Care (IQ Healthcare); Netherlands
   Institute for Health Services Research (NIVEL); Netherlands Institute of
   Mental Health and Addiction (Trimbos); ZonMw: The Netherlands
   Organization for Health Research and Development [636310017]; NWO-VICI
   [91811602]; ZonMw-reserach program GGZ grant [636310017]; NHMRC Career
   Development Fellowship [1140764]
FX This work was supported by the Geestkracht program of the Netherlands
   Organization for Health Research and Development (ZonMw, grant number
   10-000-1002) and is also supported by participating universities and
   mental health care organizations (VU University Medical Center, GGZ
   inGeest, Arkin, Leiden University Medical Center, GGZ Rivierduinen,
   University Medical Center Groningen, Lentis, GGZ Friesland, GGZ Drenthe,
   Institute for Quality of Health Care (IQ Healthcare) , Netherlands
   Institute for Health Services Research (NIVEL) and Netherlands Institute
   of Mental Health and Addiction (Trimbos) ) . Funding was also provided
   by ZonMw: The Netherlands Organization for Health Research and
   Development (project number: 636310017, research programme GGZ) . Data
   conduct and collection of the MOTAR study was funded by a NWO-VICI grant
   (number 91811602) , and funding for inflammatory markers was provided by
   a ZonMw-reserach program GGZ grant (number 636310017) . LS is supported
   by a NHMRC Career Development Fellowship (1140764) .
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NR 61
TC 12
Z9 12
U1 1
U2 13
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD SEP 1
PY 2022
VL 312
BP 268
EP 274
DI 10.1016/j.jad.2022.06.056
EA JUN 2022
PG 7
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA 2U3FN
UT WOS:000823045100032
PM 35760189
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Donnelly, R
   Cha, H
   Umberson, D
AF Donnelly, Rachel
   Cha, Hyungmin
   Umberson, Debra
TI Multiple Family Member Deaths and Cardiometabolic Health among Black and
   White Older Adults
SO JOURNAL OF HEALTH AND SOCIAL BEHAVIOR
LA English
DT Article
DE bereavement; cardiometabolic health; race; racial disadvantage; stress
ID EARLY PARENTAL DEATH; LIFE-COURSE; CUMULATIVE ADVERSITY; SOCIAL
   RELATIONSHIPS; CHILDHOOD ADVERSITY; DEMENTIA RISK; MENTAL-HEALTH;
   UNITED-STATES; STRESS; DISADVANTAGE
AB Although the bereavement literature is voluminous, we know very little about how exposure to multiple family member deaths across the life course shapes health trajectories as people age and whether unequal exposure to bereavement contributes to racial inequities in cardiometabolic health. We use longitudinal data from the Health and Retirement Study (1992-2016) to consider how multiple family member deaths before midlife shape trajectories of cardiometabolic health after age 50 for Black and white adults (n = 22,974). Results show that multiple family member deaths prior to age 50 are associated with more cardiometabolic conditions at age 50 and a faster increase in conditions with advancing age. Moreover, Black adults are significantly disadvantaged by a greater risk of bereavement and more cardiometabolic conditions regardless of bereavement status. The life course trauma of exposure to multiple family member deaths uniquely contributes to the cardiometabolic risk of Black Americans.
C1 [Donnelly, Rachel] Vanderbilt Univ, Sociol, Nashville, TN 37235 USA.
   [Cha, Hyungmin] Univ Texas Austin, Dept Sociol, Austin, TX 78712 USA.
   [Umberson, Debra] Univ Texas Austin, Sociol, Austin, TX 78712 USA.
   [Umberson, Debra] Univ Texas Austin, Ctr Aging & Populat Sci, Austin, TX 78712 USA.
C3 Vanderbilt University; University of Texas System; University of Texas
   Austin; University of Texas System; University of Texas Austin;
   University of Texas System; University of Texas Austin
RP Donnelly, R (corresponding author), Vanderbilt Univ, Dept Sociol, PMB 351811, Nashville, TN 37235 USA.
EM Rachel.donnelly@vanderbilt.edu
OI Cha, Hyungmin/0000-0002-2385-7854; Donnelly, Rachel/0000-0003-1374-0131
FU National Institutes of Health [R01AG054624, R01 AG054624-01A1S];
   National Institute on Aging [P30AG066614]; Eunice Kennedy Shriver
   National Institute of Child Health and Human Development [P2CHD042849];
   Eunice Kennedy Shriver National Institute of Child Health and Human
   Development [P2CHD042849] Funding Source: NIH RePORTER; National
   Institute on Aging [R01AG054624] Funding Source: NIH RePORTER
FX The authors disclosed receipt of the following financial support for the
   research, authorship, and/or publication of this article: This research
   was supported, in part, by the National Institutes of Health
   (R01AG054624 and R01 AG054624-01A1S), by Grant P30AG066614 awarded to
   the Center on Aging and Population Sciences at The University of Texas
   at Austin by the National Institute on Aging, and by Grant P2CHD042849
   awarded to the Population Research Center at The University of Texas at
   Austin by the Eunice Kennedy Shriver National Institute of Child Health
   and Human Development.
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NR 70
TC 4
Z9 4
U1 0
U2 13
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0022-1465
EI 2150-6000
J9 J HEALTH SOC BEHAV
JI J. Health Soc. Behav.
PD DEC
PY 2022
VL 63
IS 4
BP 610
EP 625
DI 10.1177/00221465221114485
EA AUG 2022
PG 16
WC Public, Environmental & Occupational Health; Psychology, Social; Social
   Sciences, Biomedical; Sociology
WE Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; Psychology; Biomedical
   Social Sciences; Sociology
GA 8B3TB
UT WOS:000836863800001
PM 35932108
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Yancura, LA
   Aldwin, CM
   Levenson, MR
   Spiro, A
AF Yancura, Loriena A.
   Aldwin, Carolyn M.
   Levenson, Michael R.
   Spiro, Avron, III
TI Coping, affect, and the metabolic syndrome in older men: How does coping
   get under the skin?
SO JOURNALS OF GERONTOLOGY SERIES B-PSYCHOLOGICAL SCIENCES AND SOCIAL
   SCIENCES
LA English
DT Article
ID 3RD NATIONAL-HEALTH; NEGATIVE AFFECT; EARLY-LIFE; STRESS; PREVALENCE;
   DISEASE; INTERVENTION; PERSPECTIVE; PSYCHOLOGY; EMOTIONS
AB The metabolic syndrome is a complex construct with interrelated factors of obesity, blood pressure, lipids, and glucose. It is a risk factor for a number of chronic diseases in late life. This study tested a model in which the relationship between stress and the metabolic syndrome was mediated by appraisal, coping, and affect. Data were collected from 518 male participants in the Normative Aging Study (X-age = 68.17 years). The model was partially confirmed. Relationships among stress, appraisal, coping, and affect were valenced along positive and negative pathways. However, affect was not directly related to the metabolic syndrome. The metabolic syndrome was related to positive coping as operationalized by self-regulatory strategies. The results of this study suggest that the influence of coping on physical health may occur through emotional regulation.
C1 Univ Hawaii Manoa, Dept Family & Consumer Sci, Honolulu, HI 96822 USA.
   Oregon State Univ, Dept Human Dev & Family Sci, Corvallis, OR 97331 USA.
   Boston Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02215 USA.
C3 University of Hawaii System; University of Hawaii Manoa; Oregon State
   University; Boston University
RP Yancura, LA (corresponding author), Univ Hawaii Manoa, Dept Family & Consumer Sci, Honolulu, HI 96822 USA.
RI Aldwin, Carolyn/K-9584-2013
OI Aldwin, Carolyn/0000-0002-7461-5126; Spiro III,
   Avron/0000-0003-4080-8621
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NR 63
TC 19
Z9 23
U1 0
U2 12
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1079-5014
EI 1758-5368
J9 J GERONTOL B-PSYCHOL
JI J. Gerontol. Ser. B-Psychol. Sci. Soc. Sci.
PD SEP
PY 2006
VL 61
IS 5
BP P295
EP P303
DI 10.1093/geronb/61.5.P295
PG 9
WC Geriatrics & Gerontology; Gerontology; Psychology; Psychology,
   Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Psychology
GA 085NV
UT WOS:000240611700006
PM 16960233
OA Green Submitted, Bronze
DA 2025-06-11
ER

PT J
AU Rodriguez-Cano, R
   Garey, L
   Bakhshaie, J
   Shepherd, JM
   Zvolensky, MJ
AF Rodriguez-Cano, Ruben
   Garey, Lorra
   Bakhshaie, Jafar
   Shepherd, Justin M.
   Zvolensky, Michael J.
TI The synergetic effect of alcohol consumption and cigarettes per day on
   smoking outcomes expectancies among Latinx adult smokers
SO JOURNAL OF ETHNICITY IN SUBSTANCE ABUSE
LA English
DT Article
DE Alcohol consumption; smoking rate; smoking outcome expectancies; Latinx
   smokers; health disparities
ID CONSEQUENCES QUESTIONNAIRE; FAGERSTROM TEST; NICOTINE DEPENDENCE;
   ANXIETY SENSITIVITY; PSYCHOMETRIC PROPERTIES; PREDICTIVE-VALIDITY;
   METABOLIC SYNDROME; HOSPITAL ANXIETY; HEALTH; DEPRESSION
AB The present study investigated alcohol consumption and cigarettes per day in relation to smoking outcome expectancies among Spanish-speaking Latinx daily smokers (N = 371). There was a significant interaction between alcohol consumption and number of cigarettes per day on positive smoking expectancies. Specifically, alcohol consumption has a stronger association with positive expectancies for smoking at lower rates of cigarettes per day. No such interaction was evident for negative consequence smoking expectancies. The current study highlights the potential importance of alcohol consumption and smoking rate for better understanding smoking outcome expectancies among Latinx smokers.
C1 [Rodriguez-Cano, Ruben; Zvolensky, Michael J.] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA.
   [Rodriguez-Cano, Ruben; Garey, Lorra; Shepherd, Justin M.; Zvolensky, Michael J.] Univ Houston, Houston, TX USA.
   [Bakhshaie, Jafar] Baylor Coll Med, Houston, TX 77030 USA.
   [Zvolensky, Michael J.] Univ Houston, HEALTH Inst, Houston, TX USA.
C3 University of Texas System; UTMD Anderson Cancer Center; University of
   Houston System; University of Houston; Baylor College of Medicine;
   University of Houston System; University of Houston
RP Zvolensky, MJ (corresponding author), Univ Houston, Dept Psychol, 3695 Cullen Blvd,Room 126, Houston, TX 77204 USA.
EM mjzvolen@central.uh.edu
RI ; Rodriguez-Cano, Ruben/Z-1922-2019
OI Shepherd, Justin/0000-0002-5587-8967; bakhshaie,
   jafar/0000-0002-5906-1292; Rodriguez-Cano, Ruben/0000-0001-6934-2939
FU Cancer Prevention and Research Institute of Texas (CPRIT) [RP170259]; MD
   Anderson's Cancer Center Support Grant - National Cancer Institute
   [CA016672]
FX Ruben Rodriguez-Cano was granted with a Post-doctoral Fellowship by The
   Cancer Prevention and Research Institute of Texas (CPRIT) (ID RP170259),
   and by the MD Anderson's Cancer Center Support Grant (CA016672) funded
   by the National Cancer Institute.
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NR 77
TC 9
Z9 9
U1 0
U2 8
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 1533-2640
EI 1533-2659
J9 J ETHN SUBST ABUSE
JI J. Ethn. Subst. Abuse
PD AUG 4
PY 2022
VL 21
IS 3
BP 975
EP 996
DI 10.1080/15332640.2020.1815114
EA SEP 2020
PG 22
WC Substance Abuse
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Substance Abuse
GA 3N9JN
UT WOS:000568910700001
PM 32915108
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Kitamura, Y
   Oikawa, S
   Chang, J
   Mori, Y
   Ichihara, G
   Ichihara, S
AF Kitamura, Yuki
   Oikawa, Shinji
   Chang, Jie
   Mori, Yurie
   Ichihara, Gaku
   Ichihara, Sahoko
TI Carbonylated Proteins as Key Regulators in the Progression of Metabolic
   Syndrome
SO ANTIOXIDANTS
LA English
DT Article
DE metabolic syndrome; adipose tissue; proteomics; oxidative stress;
   carbonylated proteins
ID OXIDATIVE STRESS; INSULIN-RESISTANCE; GELSOLIN; MODEL; RAT; DYSFUNCTION;
   OBESITY; CANCER
AB Based on the known role of oxidative stress in the pathogenesis and progression of metabolic syndrome, we used two-dimensional gel electrophoresis with immunochemical detection of protein carbonyls (2D-Oxyblot) to characterize the carbonylated proteins induced by oxidative stress in spontaneously hypertensive rats/NDmcr-cp (CP), an animal model of metabolic syndrome. We also profiled the proteins that showed change of expression levels in their epididymal adipose tissue at the pre-symptomatic (6-week-old) and the symptomatic (25-week-old) stages of the metabolic syndrome. Two-dimensional fluorescence difference gel electrophoresis (2D-DIGE) combined with matrix-assisted laser desorption ionization time-of-flight tandem mass spectrometry (MALDI-TOF/TOF MS) was used to analyze proteins extracted from the epididymal adipose tissue. The up-regulated proteins identified at the pre-symptomatic stage were mainly associated with ATP production and redox reaction, while the down-regulated proteins found at the symptomatic stage were involved in antioxidant activity and the tricarboxylic acid (TCA) cycle. Further analysis using the 2D-Oxyblot showed significantly high carbonylation levels of gelsolin and glycerol-3-phosphate dehydrogenase [NAD(+)] at the symptomatic stage. These results suggest that reduced antioxidant capacity underlies the increased oxidative stress state in the metabolic syndrome. The identified carbonylated proteins, including gelsolin, are potential targets that may act as key regulators in the progression of the metabolic syndrome.
C1 [Kitamura, Yuki; Oikawa, Shinji; Mori, Yurie] Mie Univ, Dept Mol & Environm Med, Grad Sch Med, Tsu 5148507, Japan.
   [Kitamura, Yuki; Ichihara, Sahoko] Jichi Med Univ, Dept Environm & Prevent Med, Sch Med, Shimotsuke 3290498, Japan.
   [Chang, Jie; Ichihara, Sahoko] Mie Univ, Grad Sch Reg Innovat Studies, Tsu 5148507, Japan.
   [Ichihara, Gaku] Tokyo Univ Sci, Dept Occupat & Environm Hlth, Noda 2788510, Japan.
   [Chang, Jie] Soochow Univ, Med Coll, Sch Publ Hlth, Dept Occupat & Environm Hlth, Suzhou 215123, Peoples R China.
   [Mori, Yurie] Gifu Univ Med Sci, Fac Pharm, Dept Pharm, Kani 5090293, Japan.
C3 Mie University; Jichi Medical University; Mie University; Tokyo
   University of Science; Soochow University - China
RP Ichihara, S (corresponding author), Jichi Med Univ, Dept Environm & Prevent Med, Sch Med, Shimotsuke 3290498, Japan.; Ichihara, S (corresponding author), Mie Univ, Grad Sch Reg Innovat Studies, Tsu 5148507, Japan.
EM kitamura.yuki@jichi.ac.jp; s-oikawa@med.mie-u.ac.jp; chang@suda.edu.cn;
   ymori@u-gifu-ms.ac.jp; gak@rs.tus.ac.jp; aho@jichi.ac.jp
RI Chang, Jie/AFR-8580-2022
OI Ichihara, Sahoko/0000-0002-7224-0949
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NR 58
TC 1
Z9 1
U1 0
U2 4
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD APR
PY 2023
VL 12
IS 4
AR 844
DI 10.3390/antiox12040844
PG 14
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA E7CE0
UT WOS:000977071900001
PM 37107219
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Hutcheson, R
   Rocic, P
AF Hutcheson, Rebecca
   Rocic, Petra
TI The Metabolic Syndrome, Oxidative Stress, Environment, and
   Cardiovascular Disease: The Great Exploration
SO EXPERIMENTAL DIABETES RESEARCH
LA English
DT Review
ID CORONARY COLLATERAL GROWTH; PARTICULATE AIR-POLLUTION; C-REACTIVE
   PROTEIN; VASCULAR SUPEROXIDE-PRODUCTION; NITRIC-OXIDE SYNTHASE;
   ENDOTHELIAL DYSFUNCTION; ANGIOTENSIN-II; INSULIN-RESISTANCE;
   HEART-DISEASE; DIABETES-MELLITUS
AB The metabolic syndrome affects 30% of the US population with increasing prevalence. In this paper, we explore the relationship between the metabolic syndrome and the incidence and severity of cardiovascular disease in general and coronary artery disease (CAD) in particular. Furthermore, we look at the impact of metabolic syndrome on outcomes of coronary revascularization therapies including CABG, PTCA, and coronary collateral development. We also examine the association between the metabolic syndrome and its individual component pathologies and oxidative stress. Related, we explore the interaction between the main external sources of oxidative stress, cigarette smoke and air pollution, and metabolic syndrome and the effect of this interaction on CAD. We discuss the apparent lack of positive effect of antioxidants on cardiovascular outcomes in large clinical trials with emphasis on some of the limitations of these trials. Finally, we present evidence for successful use of antioxidant properties of pharmacological agents, including metformin, statins, angiotensin II type I receptor blockers (ARBs), and angiotensin II converting enzyme (ACE) inhibitors, for prevention and treatment of the cardiovascular complications of the metabolic syndrome.
C1 [Hutcheson, Rebecca; Rocic, Petra] Univ S Alabama, Coll Med, Dept Biochem & Mol Biol, Mobile, AL 36688 USA.
C3 University of South Alabama
RP Rocic, P (corresponding author), Univ S Alabama, Coll Med, Dept Biochem & Mol Biol, 307 N Univ Blvd, Mobile, AL 36688 USA.
EM procic@usouthal.edu
FU AHA [11PRE7690011]; NIH [R01 HL093052]; American Heart Association (AHA)
   [11PRE7690011] Funding Source: American Heart Association (AHA)
FX This paper was supported by AHA 11PRE7690011 (R. Hutcheson) and NIH R01
   HL093052 (P. Rocic).
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NR 142
TC 101
Z9 102
U1 0
U2 25
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1687-5214
EI 1687-5303
J9 EXP DIABETES RES
JI Exp. Diabetes Res.
PY 2012
AR 271028
DI 10.1155/2012/271028
PG 13
WC Endocrinology & Metabolism; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Research & Experimental Medicine
GA 991LL
UT WOS:000307702500001
OA Green Published, hybrid, Green Submitted
DA 2025-06-11
ER

PT J
AU Purohith, R
   Nagalingaswamy, NPM
   Shivananju, NS
AF Purohith, Raghunandan
   Nagalingaswamy, Nagendra P. M.
   Shivananju, Nanjunda S.
TI Dietary Carotenoids in Managing Metabolic Syndrome and Role of PPARs in
   the Process
SO CURRENT NUTRITION & FOOD SCIENCE
LA English
DT Review
DE Antioxidants; carotenoids; dyslipidemia; metabolic syndrome; oxidative
   stress; peroxisome proliferator activated receptors
ID PROLIFERATOR-ACTIVATED RECEPTORS; OXIDATIVE STRESS; IN-VITRO;
   LIPID-ACCUMULATION; DIABETES-MELLITUS; BETA-CAROTENE; VITAMIN-C;
   LYCOPENE; GAMMA; ASTAXANTHIN
AB Metabolic syndrome is a collective term that denotes disorder in metabolism, symptoms of which include hyperglycemia, byperlipidemia, hypertension, and endothelial dysfunction. Diet is a major predisposing factor in the development of metabolic syndrome, and dietary intervention is necessary for both prevention and management. The bioactive constituents of food play a key role in this process. Micronutrients such as vitamins, carotenoids, amino acids, flavonoids, minerals, and aromatic pigment molecules found in fruits, vegetables, spices, and condiments are known to have beneficial effects in preventing and managing metabolic syndrome. There exists a well-established relationship between oxidative stress and major pathological conditions such as inflammation, metabolic syndrome, and cancer. Consequently, dietary antioxidants are implicated in the remediation of these complications. The mechanism of action and targets of dietary antioxidants as well as their effects on related pathways are being extensively studied and elucidated in recent times. This review attempts a comprehensive study of the role of dietary carotenoids in alleviating metabolic syndrome with an emphasis on molecular mechanism-in the light of recent advances.
C1 [Purohith, Raghunandan; Nagalingaswamy, Nagendra P. M.; Shivananju, Nanjunda S.] JSS Sci & Technol Univ, Sri Jayachamarajendra Engn Coll, Dept Biotechnol, JSS Tech Inst Campus, Mysuru 570005, Karnataka, India.
C3 JSS Science & Technology University
RP Shivananju, NS (corresponding author), JSS Sci & Technol Univ, Sri Jayachamarajendra Engn Coll, Dept Biotechnol, JSS Tech Inst Campus, Mysuru 570005, Karnataka, India.
EM nanjuchem@gmail.com
RI Biotechnology, NANJUNDASWAMY S/IXW-5072-2023
OI SHIVANANJU, NANJUNDA SWAMY/0000-0002-5494-9428
FU Department of Science and Technology, New Delhi, Government of India
   [DST/INDO/SOUTH AFRICA/P-12/2014]
FX The authors acknowledge the financial support by the Department of
   Science and Technology, New Delhi, Government of India under the project
   vide No DST/INDO/SOUTH AFRICA/P-12/2014 grant.
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NR 80
TC 0
Z9 0
U1 0
U2 5
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1573-4013
EI 2212-3881
J9 CURR NUTR FOOD SCI
JI Curr. Nutr. Food Sci.
PY 2020
VL 16
IS 6
BP 846
EP 853
DI 10.2174/1573401315666190619111557
PG 8
WC Nutrition & Dietetics
WE Emerging Sources Citation Index (ESCI)
SC Nutrition & Dietetics
GA MO2SC
UT WOS:000551381400001
DA 2025-06-11
ER

PT J
AU Furukawa, S
   Fujita, T
   Shimabukuro, M
   Iwaki, M
   Yamada, Y
   Nakajima, Y
   Nakayama, O
   Makishima, M
   Matsuda, M
   Shimomura, I
AF Furukawa, S
   Fujita, T
   Shimabukuro, M
   Iwaki, M
   Yamada, Y
   Nakajima, Y
   Nakayama, O
   Makishima, M
   Matsuda, M
   Shimomura, I
TI Increased oxidative stress in obesity and its impact on metabolic
   syndrome
SO JOURNAL OF CLINICAL INVESTIGATION
LA English
DT Article
ID INDUCED INSULIN-RESISTANCE; ALPHA-LIPOIC ACID; NAD(P)H OXIDASE;
   SUPEROXIDE-PRODUCTION; GLUT4 TRANSLOCATION; LIPID-PEROXIDATION; 3T3-L1
   ADIPOCYTES; PROMOTER ACTIVITY; ADIPOSE-TISSUE; ADIPONECTIN
AB Obesity is a principal causative factor in the development of metabolic syndrome. Here we report that increased oxidative stress in accumulated fat is an important pathogenic mechanism of obesity-associated metabolic syndrome. Fat accumulation correlated with systemic oxidative stress in humans and mice. Production of ROS increased selectively in adipose tissue of obese mice, accompanied by augmented expression of NADPH oxidase and decreased expression of antioxidative enzymes. In cultured adipocytes, elevated levels of fatty acids increased oxidative stress via NADPH oxidase activation, and oxidative stress caused dysregulated production of adipocytokines (fat-derived hormones), including adiponectin, plasminogen activator inhibitor-1, IL-6, and monocyte chemotactic protein-1. Finally, in obese mice, treatment with NADPH oxidase inhibitor reduced ROS production in adipose tissue, attenuated the dysregulation of adipocytokines, and improved diabetes, hyperlipidemia, and hepatic steatosis. Collectively, our results suggest that increased oxidative stress in accumulated fat is an early instigator of metabolic syndrome and that the redox state in adipose tissue is a potentially useful therapeutic target for obesity-associated metabolic syndrome.
C1 Osaka Univ, Grad Sch Med, Dept Internal Med & Mol Sci, Suita, Osaka 5650871, Japan.
   Osaka Univ, Grad Sch Frontier Biosci, Dept Organismal Biosyst, Grad Sch Med,Dept Med & Pathophysiol, Suita, Osaka 5650871, Japan.
   Univ Ryukyus, Dept Internal Med 2, Okinawa, Japan.
   Fujisawa Pharmaceut Co Ltd, Exploratory Res Labs, Tsukuba, Ibaraki 30026, Japan.
   Japan Sci & Technol Corp, PRESTO, Kawaguchi, Saitama, Japan.
C3 The University of Osaka; The University of Osaka; University of the
   Ryukyus; Astellas Pharmaceuticals; Japan Science & Technology Agency
   (JST)
RP Osaka Univ, Grad Sch Med, Dept Internal Med & Mol Sci, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan.
EM mmatsuda@fbs.osaka-u.ac.jp
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NR 66
TC 3856
Z9 4007
U1 12
U2 478
PU AMER SOC CLINICAL INVESTIGATION INC
PI ANN ARBOR
PA 2015 MANCHESTER RD, ANN ARBOR, MI 48104 USA
SN 0021-9738
EI 1558-8238
J9 J CLIN INVEST
JI J. Clin. Invest.
PD DEC
PY 2004
VL 114
IS 12
BP 1752
EP 1761
DI 10.1172/JCI20042162S
PG 10
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 879DE
UT WOS:000225695800010
PM 15599400
DA 2025-06-11
ER

PT J
AU DeGutis, J
   Chiu, C
   Thai, M
   Esterman, M
   Milberg, W
   McGlinchey, R
AF DeGutis, Joseph
   Chiu, Christopher
   Thai, Michelle
   Esterman, Michael
   Milberg, William
   McGlinchey, Regina
TI Trauma Sequelae are Uniquely Associated with Components of Self-Reported
   Sleep Dysfunction in OEF/OIF/OND Veterans
SO BEHAVIORAL SLEEP MEDICINE
LA English
DT Article
ID POSTTRAUMATIC-STRESS-DISORDER; SEXUAL ASSAULT SURVIVORS;
   COGNITIVE-BEHAVIORAL THERAPY; ADMINISTERED PTSD SCALE; QUALITY INDEX
   ADDENDUM; BRAIN-INJURY; PSYCHOMETRIC PROPERTIES; RESILIENCE INVENTORY;
   NICOTINE DEPENDENCE; CHRONIC NIGHTMARES
AB While the associations between psychological distress (e.g., posttraumatic stress disorder [PTSD], depression) and sleep dysfunction have been demonstrated in trauma-exposed populations, studies have not fully explored the associations between sleep dysfunction and the wide range of common physical and physiological changes that can occur after trauma exposure (e.g., pain, cardiometabolic risk factors). We aimed to clarify the unique associations of psychological and physical trauma sequelae with different aspects of self-reported sleep dysfunction. A comprehensive psychological and physical examination was administered to 283 combat-deployed trauma-exposed Operation Enduring Freedom/Operation Iraqi Freedom/Operation New Dawn (OEF/OIF/OND) veterans. The Pittsburgh Sleep Quality Index (PSQI) and PSQI Addendum for PSTD (PSQI-A) were administered along with measures of PTSD, depression, anxiety, pain, traumatic brain injury, alcohol use, nicotine dependence, and cardiometabolic symptoms. We first performed a confirmatory factor analysis of the PSQI and then conducted regressions with the separate PSQI factors as well as the PSQI-A to identify unique associations between trauma-related measures and the separate aspects of sleep. We found that the PSQI global score was composed of three factors: Sleep Efficiency (sleep efficiency/sleep duration), Perceived Sleep Quality (sleep quality/sleep latency/sleep medication) and Daily Disturbances (sleep disturbances/daytime dysfunction). Linear regressions demonstrated that PTSD symptoms were uniquely associated with the PSQI global score and all three factors, as well as the PSQI-A. For the other psychological distress variables, anxiety was independently associated with PSQI global as well as Sleep Efficiency, Perceived Sleep Quality, and PSQI-A, whereas depression was uniquely associated with Daily Disturbances and PSQI-A. Notably, cardiometabolic symptoms explained independent variance in PSQI global and Sleep Efficiency. These findings help lay the groundwork for further investigations of the mechanisms of sleep dysfunction in trauma-exposed individuals and may help in the development of more effective, individualized treatments.
C1 [DeGutis, Joseph; Chiu, Christopher; Thai, Michelle; Esterman, Michael] Boston Div VA Healthcare Syst, Boston Attent & Learning Lab, Boston, MA USA.
   [DeGutis, Joseph; Chiu, Christopher; Thai, Michelle; Esterman, Michael; Milberg, William; McGlinchey, Regina] Boston Div VA Healthcare Syst, Geriatr Res Educ & Clin Ctr, Boston, MA USA.
   [DeGutis, Joseph] Harvard Med Sch, Dept Med, Boston, MA USA.
   [Esterman, Michael] Boston Univ, Sch Med, Dept Psychiat, Boston, MA 02118 USA.
   [Milberg, William; McGlinchey, Regina] VA Boston Healthcare Syst, Translat Res Ctr TBI & Stress Disorders TRACTS, VA RR&D TBI Ctr Excellence, Boston, MA USA.
C3 Geriatric Research Education & Clinical Center; Harvard University;
   Harvard Medical School; Boston University; Harvard University; Harvard
   University Medical Affiliates; US Department of Veterans Affairs;
   Veterans Health Administration (VHA); VA Boston Healthcare System
RP DeGutis, J (corresponding author), Boston VA Healthcare Syst, GRECC, 150 S Huntington Ave,182-JP, Boston, MA 02130 USA.
EM degutis@wjh.harvard.edu
RI Thai, Michelle/KWT-7074-2024
OI Thai, Michelle/0000-0003-1520-6047; Esterman,
   Michael/0000-0002-9000-3920
FU Translational Research Center for TBI and Stress Disorders (TRACTS), a
   VA Rehabilitation Research and Development Traumatic Brain Injury Center
   of Excellence [B9254-C]; Veterans Affairs Career Development Award II;
   VA Clinical Science R&D Career Development Award [1IK2CX000706-01A2]
FX This research was supported by the Translational Research Center for TBI
   and Stress Disorders (TRACTS), a VA Rehabilitation Research and
   Development Traumatic Brain Injury Center of Excellence (B9254-C); by a
   Veterans Affairs Career Development Award II given to JD; and a VA
   Clinical Science R&D Career Development Award to ME (1IK2CX000706-01A2).
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NR 99
TC 15
Z9 17
U1 0
U2 8
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 1540-2002
EI 1540-2010
J9 BEHAV SLEEP MED
JI Behav. Sleep Med.
PY 2018
VL 16
IS 1
BP 38
EP 63
DI 10.1080/15402002.2016.1173550
PG 26
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA FP6IO
UT WOS:000417729400003
PM 27183394
DA 2025-06-11
ER

PT J
AU Lee, WC
   Chuang, YC
   Chiang, PH
   Chien, CT
   Yu, HJ
   Wu, CC
AF Lee, Wei-Chia
   Chuang, Yao-Chi
   Chiang, Po-Hui
   Chien, Chiang-Ting
   Yu, Hong-Jeng
   Wu, Chia-Ching
TI Pathophysiological Studies of Overactive Bladder and Bladder Motor
   Dysfunction in a Rat Model of Metabolic Syndrome
SO JOURNAL OF UROLOGY
LA English
DT Article
DE urinary bladder; urinary bladder, overactive; insulin resistance;
   metabolic syndrome X; fructose
ID URINARY-TRACT SYMPTOMS; OXIDATIVE STRESS; DIABETIC-NEUROPATHY; FRUCTOSE;
   APOPTOSIS; WOMEN; CONTRACTION; PREVALENCE; EXPRESSION; THERAPY
AB Purpose: We studied bladder motor dysfunction and searched for markers of neurogenic and myogenic alterations among fructose fed rats with or without abnormal voiding behavior.
   Materials and Methods: Female Wistar rats were fed with a fructose rich diet (60%) or a normal diet for 6 months. Based on cystometry and voiding behavior the fructose fed rats were divided into 3 groups, including a group with normal detrusor function with normal micturition frequency, a group with detrusor overactivity with increased micturition frequency and a group with acontractile detrusor with increased micturition frequency. Denuded bladder tissues were obtained to assess in vitro detrusor contractility, postsynaptic receptors, smoothelin, nitrosative products and the intrinsic pathway of apoptosis.
   Results: Fructose fed rats with abnormal voiding behavior had obvious neurogenic and myogenic alterations, including increased expression of postsynaptic receptors, dysregulation of smoothelin and decreased expression of Bcl-2 with a subsequent increase in apoptotic cells in the bladder stroma, causing decreased carbachol induced contractility. Rats with detrusor overactivity were also insulted by nitrosative stress associated with nitrotyrosine up-regulation in the bladder tissue. Up-regulation of M(2) and M(3)-muscarinic receptors, and P2X(1) receptors appeared to be generalized alterations of fructose fed rats and not exclusive to those with detrusor overactivity.
   Conclusions: Up-regulation of postsynaptic receptors and dysregulation of smoothelin contribute to overactive bladder symptoms in rats with metabolic syndrome. Nitrosative stress and decreased Bcl-2 expression lead to bladder muscle cell loss via the intrinsic pathway of apoptosis, which may further deteriorate bladder function.
C1 [Lee, Wei-Chia] Natl Taiwan Univ, Coll Med, Grad Inst Clin Med, Taipei 100, Taiwan.
   [Chien, Chiang-Ting] Natl Taiwan Univ Hosp, Dept Med Res, Taipei, Taiwan.
   [Yu, Hong-Jeng] Natl Taiwan Univ Hosp, Dept Urol, Taipei, Taiwan.
   [Wu, Chia-Ching] Cheng Shiu Univ, Coll Commerce & Management, Dept Int Business, Kaohsiung, Taiwan.
   [Lee, Wei-Chia; Chuang, Yao-Chi; Chiang, Po-Hui] Chang Gung Univ, Coll Med, Kaohsiung Med Ctr, Div Urol,Chang Gung Mem Hosp, Kaohsiung, Taiwan.
C3 National Taiwan University; National Taiwan University; National Taiwan
   University Hospital; National Taiwan University; National Taiwan
   University Hospital; Cheng Shiu University; Chang Gung Memorial
   Hospital; Chang Gung University
RP Yu, HJ (corresponding author), Natl Taiwan Univ, Coll Med, Dept Urol & Med Res, 7 Chung Shan S Rd, Taipei 100, Taiwan.
EM yhj5251@ntu.edu.tw
OI YU, HONG-JENG/0000-0003-3287-5736; Lee, Wei-Chia/0000-0003-0701-2285;
   Chuang, Yao-Chi/0000-0002-1468-3792
FU National Science Council of the Republic of China
   [NSC97-2314-B-182A-081, NSC99-2628-B-002-058-MY3]; Chang Gung Memorial
   Hospital [CMRPG870201, CMRPG880281]
FX Supported by Grants NSC97-2314-B-182A-081 and NSC99-2628-B-002-058-MY3
   from the National Science Council of the Republic of China, and
   CMRPG870201 and CMRPG880281 from Chang Gung Memorial Hospital.
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NR 30
TC 40
Z9 41
U1 0
U2 5
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0022-5347
J9 J UROLOGY
JI J. Urol.
PD JUL
PY 2011
VL 186
IS 1
BP 318
EP 325
DI 10.1016/j.juro.2011.03.037
PG 8
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 775PH
UT WOS:000291472900109
PM 21600594
DA 2025-06-11
ER

PT J
AU Miralles-Pérez, B
   Nogués, MR
   Sánchez-Martos, V
   Fortuño-Mar, A
   Ramos-Romero, S
   Torres, JL
   Ponomarenko, J
   Amézqueta, S
   Zhang, X
   Romeu, M
AF Miralles-Perez, Bernat
   Rosa Nogues, Maria
   Sanchez-Martos, Vanessa
   Fortuno-Mar, Angels
   Ramos-Romero, Sara
   Torres, Josep L.
   Ponomarenko, Julia
   Amezqueta, Susana
   Zhang, Xiang
   Romeu, Marta
TI Influence of Dietary Inulin on Fecal Microbiota, Cardiometabolic Risk
   Factors, Eicosanoids, and Oxidative Stress in Rats Fed a High-Fat Diet
SO FOODS
LA English
DT Article
DE obesity; glucose intolerance; insulin resistance; dyslipidemia; fatty
   liver; gut microbiota; endogenous antioxidants; lipid peroxidation
ID INSULIN-RESISTANCE; GENE-EXPRESSION; INDUCED OBESITY; GUT MICROBIOTA;
   FIBER; ACID; CATALASE; GLUCOSE; PLASMA; ASSAY
AB The present study examined the influence of inulin on fecal microbiota, cardiometabolic risk factors, eicosanoids, and oxidative stress in rats on a high-fat (HF) diet. Thirty-six male Wistar-Kyoto rats were divided into three dietary groups: standard diet, HF diet, and HF diet + Inulin diet. After 10 weeks, the HF + Inulin diet promoted high dominance of a few bacterial genera including Blautia and Olsenella in feces while reducing richness, diversity, and rarity compared to the HF diet. These changes in fecal microbiota were accompanied by an increased amount of propionic acid in feces. The HF + Inulin diet decreased cardiometabolic risk factors, decreased the amount of the eicosanoids 11(12)-EET and 15-HETrE in the liver, and decreased oxidative stress in blood compared to the HF diet. In conclusion, increasing consumption of inulin may be a useful nutritional strategy to protect against the onset of obesity and its associated metabolic abnormalities by means of modulation of gut microbiota.
C1 [Miralles-Perez, Bernat; Rosa Nogues, Maria; Sanchez-Martos, Vanessa; Romeu, Marta] Univ Rovira & Virgili, Dept Basic Med Sci, Funct Nutr Oxidat & Cardiovasc Dis Res Grp NFOC S, Pharmacol Unit, C St Llorenc 21, E-43201 Reus, Spain.
   [Fortuno-Mar, Angels] Eldine Patol, C Plom 32, E-43006 Tarragona, Spain.
   [Ramos-Romero, Sara; Torres, Josep L.] CSIC, Dept Biol Chem, Inst Adv Chem Catalonia IQAC, C Jordi Girona 1826, E-08034 Barcelona, Spain.
   [Ramos-Romero, Sara] Univ Barcelona, Fac Biol, Dept Cell Biol Physiol & Immunol, Avd Diagonal 643, E-08028 Barcelona, Spain.
   [Ponomarenko, Julia] Univ Pompeu Fabra UPF, Ctr Genom Regulat, Barcelona Inst Sci & Technol, E-08003 Barcelona, Spain.
   [Amezqueta, Susana] Univ Barcelona, Dept Engn Quim & Quim Analit, E-08028 Barcelona, Spain.
   [Amezqueta, Susana] Univ Barcelona, Inst Biomed IBUB, E-08028 Barcelona, Spain.
   [Zhang, Xiang] Univ Louisville, Dept Chem, 2210 S Brook St, Louisville, KY 40292 USA.
C3 Universitat Rovira i Virgili; Consejo Superior de Investigaciones
   Cientificas (CSIC); CSIC - Centro de Investigacion y Desarrollo Pascual
   Vila (CID-CSIC); CSIC - Instituto de Quimica Avanzada de Cataluna
   (IQAC); University of Barcelona; Barcelona Institute of Science &
   Technology; Pompeu Fabra University; Centre de Regulacio Genomica (CRG);
   University of Barcelona; University of Barcelona; University of
   Louisville
RP Nogués, MR (corresponding author), Univ Rovira & Virgili, Dept Basic Med Sci, Funct Nutr Oxidat & Cardiovasc Dis Res Grp NFOC S, Pharmacol Unit, C St Llorenc 21, E-43201 Reus, Spain.
RI Torres, Josep/N-7256-2013; Ramos-Romero, Sara/AAH-6209-2020; ROMEU,
   MARTA/O-7129-2019; Miralles-Pérez, Bernat/ABI-2034-2020; Nogués,
   M./ABH-5645-2020; Ramos-Romero, Sara/K-8301-2017; ROMEU,
   MARTA/A-8468-2014
OI Miralles-Perez, Bernat/0000-0003-1294-7069; Zhang,
   Xiang/0000-0003-1102-6313; Ramos-Romero, Sara/0000-0002-9293-4454;
   ROMEU, MARTA/0000-0002-2131-1858
FU Spanish Ministry of Economy and Competitiveness [AGL2017-83599-R]; MEIC;
   Centro de Excelencia Severo Ochoa; CERCA Programme/Generalitat de
   Catalunya
FX This work was supported by the Spanish Ministry of Economy and
   Competitiveness (grant number: AGL2017-83599-R). J.P. was supported by
   the MEIC to the EMBL partnership, Centro de Excelencia Severo Ochoa and
   CERCA Programme/Generalitat de Catalunya.
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NR 87
TC 7
Z9 7
U1 2
U2 20
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2304-8158
J9 FOODS
JI Foods
PD DEC
PY 2022
VL 11
IS 24
AR 4072
DI 10.3390/foods11244072
PG 21
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA 7G6EH
UT WOS:000902614500001
PM 36553814
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Alonso, Y
   Miralles, C
   Algora, MJ
   Valiente-Pallejà, A
   Sánchez-Gistau, V
   Muntané, G
   Labad, J
   Vilella, E
   Martorell, L
AF Alonso, Yolanda
   Miralles, Carmen
   Algora, M. Jose
   Valiente-Palleja, Alba
   Sanchez-Gistau, Vanessa
   Muntane, Gerard
   Labad, Javier
   Vilella, Elisabet
   Martorell, Lourdes
TI Risk factors for metabolic syndrome in individuals with recent-onset
   psychosis at disease onset and after 1-year follow-up
SO SCIENTIFIC REPORTS
LA English
DT Article
ID 1ST-EPISODE SCHIZOPHRENIA-PATIENTS; CARDIOVASCULAR RISK;
   PHYSICAL-ACTIVITY; CARDIOMETABOLIC RISK; SPECTRUM DISORDERS; SPANISH
   VERSION; MENTAL STATES; SEX; PREVALENCE; VALIDATION
AB Metabolic syndrome (MetS) is a cluster of parameters encompassing the most dangerous heart attack risk factors, associated with increased morbidity and mortality. It is highly prevalent in recent-onset psychosis (ROP) patients. In this pilot study, we evaluated MetS parameters (fasting glucose, high-density lipoprotein (HDL) cholesterol (HDL-c), fasting triglycerides, waist circumference, and systolic and diastolic blood pressure), clinical symptoms, pharmacological treatment, lifestyle, and inflammatory markers in 69 patients with ROP and 61 healthy controls (HCs). At baseline, waist circumference (p = 0.005) and fasting triglycerides (p = 0.007) were higher in patients with ROP than in HCs. At the 1-year follow-up, patients showed clinical improvement, with a reduction in the positive and negative syndrome scale (PANSS) score (p < 0.001), dietary intake (p = 0.001), and antipsychotic medication dose (p < 0.001); however, fasting glucose (p = 0.011), HDL-c (p = 0.013) and waist circumference worsened (p < 0.001). We identified sex, age, BMI, dietary intake, physical activity, daily tobacco use, daily cannabis use, and antipsychotic doses as risk factors contributing to baseline MetS parameters. After 1-year follow-up, those factors plus the PANSS and Calgary Depression Scale for Schizophrenia (CDSS) scores were associated with MetS parameters. Further studies are needed to understand the contributions of the studied risk factors in patients with ROP at onset and during disease progression.
C1 [Alonso, Yolanda; Miralles, Carmen; Algora, M. Jose; Valiente-Palleja, Alba; Sanchez-Gistau, Vanessa; Muntane, Gerard; Vilella, Elisabet; Martorell, Lourdes] Hosp Univ Inst Pere Mata, Ctra lInstitut Pere Mata,S N, Reus 43206, Spain.
   [Alonso, Yolanda; Miralles, Carmen; Algora, M. Jose; Valiente-Palleja, Alba; Sanchez-Gistau, Vanessa; Muntane, Gerard; Vilella, Elisabet; Martorell, Lourdes] Inst Invest Sanitaria Pere Virgili CERCA, Reus 43204, Spain.
   [Alonso, Yolanda; Valiente-Palleja, Alba; Sanchez-Gistau, Vanessa; Muntane, Gerard; Vilella, Elisabet; Martorell, Lourdes] Univ Rovira & Virgili URV, Reus 43201, Spain.
   [Alonso, Yolanda; Valiente-Palleja, Alba; Sanchez-Gistau, Vanessa; Muntane, Gerard; Labad, Javier; Vilella, Elisabet; Martorell, Lourdes] Ctr Invest Biomed Red Salud Mental, CIBERSAM Inst Salud Carlos III, Madrid 28029, Spain.
   [Muntane, Gerard] Univ Pompeu Fabra, Inst Biol Evolut, IBE, UPF, Barcelona 08003, Spain.
   [Labad, Javier] Hosp Mataro, Consorci Sanitari Maresme, Fdn Parc Tauli, Mataro 08340, Catalonia, Spain.
   [Labad, Javier] Univ Autonoma Barcelona, Inst Innovacio & Invest Parc Tauli, Translat Neurosci Res Unit I3PT INc UAB, I3PT, Barcelona 08193, Spain.
C3 Universitat Rovira i Virgili; CIBER - Centro de Investigacion Biomedica
   en Red; CIBERSAM; Pompeu Fabra University; Consejo Superior de
   Investigaciones Cientificas (CSIC); CSIC-UPF - Institut de Biologia
   Evolutiva (IBE); Autonomous University of Barcelona; Parc Tauli Hospital
   Universitari; Autonomous University of Barcelona
RP Martorell, L (corresponding author), Hosp Univ Inst Pere Mata, Ctra lInstitut Pere Mata,S N, Reus 43206, Spain.; Martorell, L (corresponding author), Inst Invest Sanitaria Pere Virgili CERCA, Reus 43204, Spain.; Martorell, L (corresponding author), Univ Rovira & Virgili URV, Reus 43201, Spain.; Martorell, L (corresponding author), Ctr Invest Biomed Red Salud Mental, CIBERSAM Inst Salud Carlos III, Madrid 28029, Spain.
EM martorelll@peremata.com
RI Labad, Javier/AAF-6632-2020; Vilella, Elisabet/HII-9781-2022; sanchez,
   vanessa/KBC-3471-2024; Muntane, Gerard/V-4477-2019
OI Martorell, Lourdes/0000-0003-4999-2197; sanchez-gistau,
   vanessa/0000-0002-8635-7144; Labad, Javier/0000-0003-2214-1886
FU Instituto de Salud Carlos III [PI18/00514, PI21/00612, PI21/01812,
   INT19/00071]; Fundacio La Marato de TV3 [092230, 092231]; Catalan Agency
   of Research and Universities (AGAUR) [2017SGR-00444]; IISPV-Cerca
   Program of the Generalitat de Catalunya; FEDER; Intensification of the
   Research Activity Grant by the Department of Health from the Generalitat
   de Catalunya [SLT006/17/00012]; Diputacio de Tarragona
FX The authors thank the participants for their contribution to the study
   and the technicians from the Biobanc-IISPV in Reus
   (http://www.iispv.cat) for excellent sample management. This work was
   supported by the Instituto de Salud Carlos III, Grant Numbers
   PI18/00514, PI21/00612 and PI21/01812; the Fundacio La Marato de TV3,
   Grant Numbers 092230 and 092231; the Catalan Agency of Research and
   Universities (AGAUR) 2017SGR-00444; the IISPV-Cerca Program of the
   Generalitat de Catalunya; and cofounded by FEDER. Javier Labad received
   an Intensification of the Research Activity Grant by the Department of
   Health from the Generalitat de Catalunya (SLT006/17/00012) between 2018
   and 2019 and from the Instituto de Salud Carlos III (INT19/00071) during
   2020. Alba Valiente-Palleja received a Talent-URV-Dipta fellowship from
   the Diputacio de Tarragona.
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NR 52
TC 7
Z9 7
U1 1
U2 4
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD JUL 6
PY 2022
VL 12
IS 1
AR 11386
DI 10.1038/s41598-022-15479-x
PG 11
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 2Y1IQ
UT WOS:000825646400050
PM 35794221
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Opie, LH
   Commerford, PJ
   Gersh, BJ
AF Opie, LH
   Commerford, PJ
   Gersh, BJ
TI Controversies in Cardiology 1 - Controversies in stable coronary artery
   disease
SO LANCET
LA English
DT Review
ID C-REACTIVE PROTEIN; DENSITY-LIPOPROTEIN CHOLESTEROL; LONG-ACTING
   NIFEDIPINE; EURO HEART SURVEY; MYOCARDIAL-INFARCTION; RISK-FACTORS;
   CARDIOVASCULAR-DISEASE; SECONDARY PREVENTION; METABOLIC SYNDROME;
   CLINICAL-PRACTICE
AB Coronary heart disease is still highly prevalent worldwide, and stable angina pectoris is one of its more common presentations. Three major controversies are risk factor management, drug therapy, and intervention. As well as the major risk factors stated by the Framingham study and European guidelines, other factors include abdominal obesity, metabolic syndrome, and psychological stress. How should these additional factors be rated? With respect to drug therapy, apart from aspirin, all patients with stable angina should be assessed for statin treatment. Although statins will reduce coronary events by about one third in patients with vascular disease, the absolute benefit depends on the absolute risk. Non-controversially, all patients should be considered for angiotensin-converting-enzyme inhibitors. The concept that beta blockers are protective from future coronary events can be disputed. Percutaneous coronary intervention can relieve symptoms without extending lifespan beyond medical therapy. However, strong mortality data favour coronary-artery bypass grafting in individuals with triple-vessel or even double-vessel disease. Thus, effort angina needs comprehensive assessment, lifestyle changes, and treatment tailored to the individual patient.
C1 Univ Cape Town, Sch Med, Observ, Hatter Inst Heart Res,Cape Heart Ctr, ZA-7925 Cape Town, South Africa.
   Univ Cape Town, Sch Med, Observ, Dept Med, ZA-7925 Cape Town, South Africa.
   Groote Schuur Hosp, Cardic Clin, Dept Med, ZA-7925 Cape Town, South Africa.
   Mayo Clin, Rochester, MN USA.
C3 University of Cape Town; University of Cape Town; University of Cape
   Town; Mayo Clinic
RP Univ Cape Town, Sch Med, Observ, Hatter Inst Heart Res,Cape Heart Ctr, ZA-7925 Cape Town, South Africa.
EM Opie@capeheart.uct.ac.za
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NR 114
TC 52
Z9 59
U1 0
U2 8
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0140-6736
EI 1474-547X
J9 LANCET
JI Lancet
PD JAN 7
PY 2006
VL 367
IS 9504
BP 69
EP 78
DI 10.1016/S0140-6736(06)67927-0
PG 10
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 000EG
UT WOS:000234443100033
PM 16399156
DA 2025-06-11
ER

PT J
AU Horváth, B
   Mukhopadhyay, P
   Haskó, G
   Pacher, P
AF Horvath, Bela
   Mukhopadhyay, Partha
   Hasko, Gyoergy
   Pacher, Pal
TI The Endocannabinoid System and Plant-Derived Cannabinoids in Diabetes
   and Diabetic Complications
SO AMERICAN JOURNAL OF PATHOLOGY
LA English
DT Review
ID CB1 RECEPTOR ANTAGONIST; ENDOPLASMIC-RETICULUM STRESS;
   CORONARY-ARTERY-DISEASE; OXIDATIVE STRESS; CELL-DEATH;
   INSULIN-SECRETION; RISK-FACTORS; CARDIOMETABOLIC RISK; OVERWEIGHT
   PATIENTS; INDUCED APOPTOSIS
AB Oxidative stress and inflammation play critical roles in the development of diabetes and its complications. Recent studies provided compelling evidence that the newly discovered lipid signaling system (ie, the endocannabinoid system) may significantly influence reactive oxygen species production, inflammation, and subsequent tissue injury, in addition to its well-known metabolic effects and functions. The modulation of the activity of this system holds tremendous therapeutic potential in a wide range of diseases, ranging from cancer, pain, neurodegenerative, and cardiovascular diseases to obesity and metabolic syndrome, diabetes, and diabetic complications. This review focuses on the role of the endocannabinoid system in primary diabetes and its effects on various diabetic complications, such as diabetic cardiovascular dysfunction, nephropathy, retinopathy, and neuropathy, particularly highlighting the mechanisms beyond the metabolic consequences of the activation of the endocannabinoid system. The therapeutic potential of targeting the endocannabinoid system and certain plant-derived cannabinoids, such as cannabidiol and Delta 9-tetra-hydrocannabivarin, which are devoid of psychotropic effects and possess potent anti-inflammatory and/or antioxidant properties, in diabetes and diabetic complications is also discussed. (Am J Pathol 2012, 180:432-442; DOI: 10.1016/j.ajpath.2011.11.003)
C1 [Horvath, Bela; Mukhopadhyay, Partha; Pacher, Pal] NIAAA, Sect Oxidat Stress Tissue Injury, Lab Physiol Studies, NIH, Bethesda, MD 20892 USA.
   [Horvath, Bela] Semmelweis Univ, Inst Human Physiol & Clin Expt Res, Budapest, Hungary.
   [Hasko, Gyoergy] Univ Med & Dent New Jersey, New Jersey Med Sch, Dept Surg, Newark, NJ 07103 USA.
C3 National Institutes of Health (NIH) - USA; NIH National Institute on
   Alcohol Abuse & Alcoholism (NIAAA); Semmelweis University; Rutgers
   University System; Rutgers University New Brunswick; Rutgers University
   Biomedical & Health Sciences
RP Pacher, P (corresponding author), NIAAA, Sect Oxidat Stress Tissue Injury, Lab Physiol Studies, NIH, 5625 Fishers Lane,MSC-9413, Bethesda, MD 20892 USA.
EM horvathba@mail.nih.gov; pacher@mail.nih.gov
RI Horvath, Bela/A-7368-2009; MUKHOPADHYAY, PARTHA/G-3890-2010; Pacher,
   Pal/B-6378-2008
OI Mukhopadhyay, Partha/0000-0002-1178-1274; Pacher,
   Pal/0000-0001-7036-8108
FU National Institute of Alcohol Abuse and Alcoholism, NIH; Hungarian
   Scientific Research Fund Fellowship [OTKA-NKTH-EU MB08 80238]
FX Supported by the Intramural Research Program of the National Institute
   of Alcohol Abuse and Alcoholism, NIH (P.P.). Dr. Horvath is a recipient
   of the Hungarian Scientific Research Fund Fellowship (OTKA-NKTH-EU MB08
   80238).
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NR 104
TC 111
Z9 119
U1 2
U2 21
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0002-9440
EI 1525-2191
J9 AM J PATHOL
JI Am. J. Pathol.
PD FEB
PY 2012
VL 180
IS 2
BP 432
EP 442
DI 10.1016/j.ajpath.2011.11.003
PG 11
WC Pathology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pathology
GA 887HZ
UT WOS:000299918800001
PM 22155112
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Ortiz, R
   Joseph, JJ
   Lee, R
   Wand, GS
   Golden, SH
AF Ortiz, Robin
   Joseph, Joshua J.
   Lee, Richard
   Wand, Gary S.
   Golden, Sherita Hill
TI Type 2 diabetes and cardiometabolic risk may be associated with increase
   in DNA methylation of FKBP5
SO CLINICAL EPIGENETICS
LA English
DT Article
DE FKBP5; Methylation; Epigenetics; Cortisol; Diabetes; Cardiovascular
   disease; Obesity; Body mass index (BMI); Waist circumference; Hemoglobin
   A1c
ID ACUTE MYOCARDIAL-INFARCTION; METABOLIC SYNDROME; INSULIN-RESISTANCE;
   SALIVARY CORTISOL; GENE-EXPRESSION; FOLLOW-UP; ATHEROSCLEROSIS; STRESS;
   MELLITUS; DEPRESSION
AB Background: Subclinical hypercortisolism and hypothalamic-pituitary-adrenal (HPA) axis dysfunction are associated with type 2 diabetes (T2DM), cardiovascular disease, and metabolic dysfunction. Intronic methyiation of FKBP5 has been implicated as a potential indicator of chronic cortisol exposure. Our overall objective in this study was to determine the association of chronic cortisol exposure, measured via percent methylation of FKBP5 at intron 2, with percent glycosylated hemoglobin (HbA1c), low-density lipoprotein cholesterol (LDL-choiesterol), waist circumference (WC), and body mass index (BMI), in a clinic-based sample of 43 individuals with T2DM.
   Results: Greater percent methylation of the FKBP5 intron 2 at one CpG-dinucleotide region was significantly associated with higher HbA1c (beta = 0.535, p = 0.003) and LDL cholesterol (beta = 0.344, p = 0.037) and a second CpG-dinucleotide region was significantly associated with higher BMI and WC (beta = 0.516, p = 0.001; beta = 0.403, p = 0.006, respectively).
   Conclusions: FKBP5 methylation may be a marker of higher metabolic risk in T2DM, possibly secondary to higher exposure to cortisol. Further work should aim to assess the longitudinal association of FKBP5 with cardiovascular disease and glycemic outcomes in T2DM as a first step in understanding potential preventive and treatment-related interventions targeting the HPA axis.
C1 [Ortiz, Robin] Johns Hopkins Univ, Sch Med, Dept Internal Med, 600 North Wolfe St,Harvey Bldg Rm 805, Baltimore, MD 21287 USA.
   [Ortiz, Robin] Johns Hopkins Univ, Sch Med, Dept Pediat, 600 North Wolfe St,Harvey Bldg Rm 805, Baltimore, MD 21287 USA.
   [Joseph, Joshua J.] Ohio State Univ, Wexner Med Ctr, Dept Med, Div Endocrinol Diabet & Metab, 566 McCampbell Hall,1581 Dodd Dr, Columbus, OH 43210 USA.
   [Lee, Richard] Johns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, 720 Rutland Ave Ross Bldg 1068, Baltimore, MD 21205 USA.
   [Wand, Gary S.; Golden, Sherita Hill] Johns Hopkins Univ, Sch Med, Dept Med, Div Endocrinol Diabet & Metab, 1830 E Monument St Suite 333, Baltimore, MD 21287 USA.
C3 Johns Hopkins University; Johns Hopkins University; University System of
   Ohio; Ohio State University; Johns Hopkins University; Johns Hopkins
   University
RP Golden, SH (corresponding author), Johns Hopkins Univ, Sch Med, Dept Med, Div Endocrinol Diabet & Metab, 1830 E Monument St Suite 333, Baltimore, MD 21287 USA.
EM Sahill@jhmi.edu
RI Lee, Richard/JBJ-7185-2023; Joseph, Joshua/NDR-8695-2025
OI Ortiz, Robin/0000-0002-0957-5850; Lee, Richard/0000-0002-3454-8774
FU National Center For Advancing Translational Sciences [UL1TR001070];
   National Institute of Diabetes, Digestive, and Kidney Diseases [R03
   DK088997]; National Institute of Alcohol Abuse and Alcoholism [U01
   AA020890]
FX The project described was supported by Award Number Grant UL1TR001070
   from the National Center For Advancing Translational Sciences. The
   content is solely the responsibility of the authors and does not
   necessarily represent the official views of the National Center For
   Advancing Translational Sciences or the National Institutes of Health.
   This study was supported by the National Institute of Diabetes,
   Digestive, and Kidney Diseases (R03 DK088997 awarded to SHG) and the
   National Institute of Alcohol Abuse and Alcoholism (U01 AA020890 awarded
   to GSW).
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NR 34
TC 29
Z9 31
U1 0
U2 6
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1868-7083
J9 CLIN EPIGENETICS
JI Clin. Epigenetics
PD JUN 19
PY 2018
VL 10
AR 82
DI 10.1186/s13148-018-0513-0
PG 8
WC Oncology; Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Genetics & Heredity
GA GK1SV
UT WOS:000435902400001
PM 29951131
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Zihl, J
   Schaaf, L
   Zillmer, EA
AF Zihl, Josef
   Schaaf, Ludwig
   Zillmer, Eric A.
TI The Relationship Between Adult Neuropsychological Profiles and Diabetic
   Patients' Glycemic Control
SO APPLIED NEUROPSYCHOLOGY
LA English
DT Article
DE anxiety; cognition; depression; Type 1 diabetes; Type 2 diabetes
ID CO-MORBID DEPRESSION; COGNITIVE FUNCTION; ACUTE HYPOGLYCEMIA;
   PSYCHOLOGICAL DISTRESS; MEMORY IMPAIRMENTS; METABOLIC SYNDROME; TYPE-1;
   PREVALENCE; ANXIETY; COMPLICATIONS
AB The purpose of this study was to assess, in relation to metabolic control, the cognitive, depressive, and anxiety symptoms among 40 adult patients (age: 18-60 years) with either type 1 (n=28) or type 2 (n=12) diabetes mellitus (DM1, DM2). Nineteen healthy subjects matched for age, gender, and education served as the control group. For most cognitive domains, no significant performance differences were found between subjects from the diabetic groups and control subjects. However, diabetes patients demonstrated reduced information processing accuracy along with impaired visual and verbal working memory performance. In addition, psychopathology scores were significantly elevated but did not reach the clinical criteria for depression or anxiety. Overall, there were no significant differences between diabetic subgroups, and no significant correlation was found between cognitive performance, psychopathology scores, and HbA1c values for either subgroup. Thus, patients with DM1 or DM2 may show mild-to-moderate cognitive impairment as well as subtle psychopathological symptoms. While cognitive impairments may be understood in terms of diabetes-associated cognitive dysfunction, psychopathological symptoms may also result from unsuccessful coping with high task demands in everyday life activities. The outcome of the current study underscores the importance of early clinical neuropsychological standardized assessment as well as the diagnosis of cognitive and psychopathological symptoms in adult patients with diabetes.
C1 [Zihl, Josef; Schaaf, Ludwig] Max Planck Inst Psychiat, D-80404 Munich, Germany.
   [Zihl, Josef] Univ Munich, Dept Psychol, Munich, Germany.
   [Zillmer, Eric A.] Drexel Univ, Dept Athlet, Philadelphia, PA 19104 USA.
C3 Max Planck Society; University of Munich; Drexel University
RP Zihl, J (corresponding author), Max Planck Inst Psychiat, Kraepelinstr 10, D-80404 Munich, Germany.
EM zihl@mpipsykl.mpg.de
OI Josef, Zihl/0000-0002-0838-0103
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NR 45
TC 11
Z9 16
U1 0
U2 13
PU PSYCHOLOGY PRESS
PI HOVE
PA 27 CHURCH RD, HOVE BN3 2FA, EAST SUSSEX, ENGLAND
SN 0908-4282
J9 APPL NEUROPSYCHOL
JI Appl. Neuropsychol.
PY 2010
VL 17
IS 1
BP 44
EP 51
AR PII 919153746
DI 10.1080/09084280903526133
PG 8
WC Clinical Neurology; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Psychology
GA 554JY
UT WOS:000274432500006
PM 20146121
DA 2025-06-11
ER

PT J
AU Campayo, A
   Gómez-Biel, CH
   Lobo, A
AF Campayo, Antonio
   Gomez-Biel, Carlos H.
   Lobo, Antonio
TI Diabetes and Depression
SO CURRENT PSYCHIATRY REPORTS
LA English
DT Article
DE Mood disorders; Diabetes mellitus; Metabolic syndrome;
   Neuroendocrinology; Liaison psychiatry
ID METABOLIC SYNDROME; COMORBID DEPRESSION; PROSPECTIVE COHORT; MAJOR
   DEPRESSION; GLOBAL BURDEN; RISK-FACTOR; TYPE-2; SYMPTOMS; MELLITUS;
   PREVALENCE
AB In a context of the potentially epidemic nature of both diabetes mellitus and depression, and the negative effects reported in cases of comorbidity, this review suggests that the association of the two conditions is multifaceted. Increased risks of prevalent depression and incident depression among diabetic patients have been reported in community studies. Even more consistent is the finding supporting psychosomatic hypotheses regarding the increased risk of diabetes among depressed patients. A recent relevant finding is the increased risk of diabetes reported in depression that is commonly found in the community, namely nonsevere, persistent, untreated depression. In view of the negative implications of the comorbidity of depression and diabetes, the suggestion that all clinically relevant cases of depression found in the community should be treated seems logical. However, new studies seem mandatory to document the efficacy of treatment of depression and the safety of antidepressant use in cases of comorbidity.
C1 [Campayo, Antonio; Gomez-Biel, Carlos H.; Lobo, Antonio] Hosp Clin Univ, Serv Psiquiatria 3A Planta, Zaragoza 50009, Spain.
   [Campayo, Antonio; Lobo, Antonio] Minist Sci & Innovat, CIBERsam, Madrid, Spain.
   [Campayo, Antonio; Lobo, Antonio] Inst Aragones Ciencias Salud I CS, Zaragoza, Spain.
C3 Universidad de la Laguna; University Hospital of the Canary Islands;
   CIBER - Centro de Investigacion Biomedica en Red; CIBERSAM
RP Campayo, A (corresponding author), Hosp Clin Univ, Serv Psiquiatria 3A Planta, Ave San Juan Bosco 15, Zaragoza 50009, Spain.
EM acampayo.iacs@aragon.es
RI Di Carlo, Antonio/AAB-9776-2022; Campayo, Antonio/C-2105-2012
OI Campayo, Antonio/0000-0002-5122-7542; Lobo, Antonio/0000-0002-9098-655X
CR Ali S, 2006, DIABETIC MED, V23, P1165, DOI 10.1111/j.1464-5491.2006.01943.x
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NR 40
TC 68
Z9 78
U1 0
U2 28
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1523-3812
J9 CURR PSYCHIAT REP
JI Curr. Psychiatry Rep.
PD FEB
PY 2011
VL 13
IS 1
BP 26
EP 30
DI 10.1007/s11920-010-0165-z
PG 5
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 752ZP
UT WOS:000289734300005
PM 21052874
DA 2025-06-11
ER

PT J
AU Topic, R
   Milicic, D
   Stimac, Z
   Loncar, M
   Velagic, V
   Marcinko, D
   Jakovljevic, M
AF Topic, Radmila
   Milicic, Davor
   Stimac, Zoran
   Loncar, Mladen
   Velagic, Vedran
   Marcinko, Darko
   Jakovljevic, Miro
TI Somatic comorbidity, metabolic syndrome, cardiovascular risk, and CRP in
   patients with recurrent depressive disorders
SO CROATIAN MEDICAL JOURNAL
LA English
DT Article
ID C-REACTIVE PROTEIN; ASSOCIATION; INFLAMMATION; SYMPTOMS
AB Aim To investigate the association between depression, metabolic syndrome (MBS), somatic, particularly cardiovascular comorbidity, and low-grade chronic inflammation assessed using C-reactive protein (CRP).
   Methods This cross-sectional study included 76 patients with recurrent depressive disorder (RDD) and 72 non-depressed medical staff controls from the Department of Psychiatry, University Hospital Center Zagreb between January 2011 and June 2012.
   Results Seventy-five percent of patients had somatic comorbidity. The most common comorbid conditions were cardiovascular disorders (46.1%), locomotor system diseases (35.5%), carcinoma (15.8%), thyroid diseases (9.2%), and diabetes (9.2%). MTB was more common in RDD patients (31.6%) than in controls (23.6%), but the difference was not significant. Elevated CRP was found to be significantly more frequent in patients with recurrent depressive disorders (RDD) (35.5%;.2 test, P = 0.001, Cramer V = 0.29) than in controls (12.5%) and was associated with lowered high-density lipoprotein and overweight/obesity.
   Conclusion We found some intriguing links between stress, depression, metabolic syndrome, and low grade inflammation, which may be relevant for the prevalence of somatic comorbidity in patients with RDD, but further studies are needed to confirm our results.
C1 [Topic, Radmila; Stimac, Zoran; Loncar, Mladen; Marcinko, Darko; Jakovljevic, Miro] Univ Zagreb, Sch Med, Dept Psychiat, Univ Clin Ctr Zagreb, Zagreb 41001, Croatia.
   [Milicic, Davor; Velagic, Vedran] Univ Zagreb, Sch Med, Dept Cardiol, Univ Clin Ctr Zagreb, Zagreb 41001, Croatia.
C3 University of Zagreb; UNIVERSITY ZAGREB HOSPITAL; University of Zagreb;
   UNIVERSITY ZAGREB HOSPITAL
RP Topic, R (corresponding author), Univ Hosp Ctr Zagreb, Dept Psychiat, Kispaticeva 12, Zagreb 10000, Croatia.
EM topicradmila@yahoo.com
RI Milicic, Davor/U-4225-2019
FU project "Multidimensional analysis of biological factors in psychiatric
   disorders" [108-1080037-0323]
FX Funding received from the project "Multidimensional analysis of
   biological factors in psychiatric disorders," No. 108-1080037-0323..
CR [Anonymous], CARDIOL RES PRACT
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NR 19
TC 23
Z9 25
U1 0
U2 7
PU MEDICINSKA NAKLADA
PI ZAGREB
PA VLASKA 69, HR-10000 ZAGREB, CROATIA
SN 0353-9504
EI 1332-8166
J9 CROAT MED J
JI Croat. Med. J.
PD OCT
PY 2013
VL 54
IS 5
BP 453
EP 459
DI 10.3325/cmj.2013.54.453
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 253OY
UT WOS:000327099800006
PM 24170724
OA Green Published, Green Accepted, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU de Araújo, WA
   Santos, ISC
   Rosa, RS
   Cruz, DP
   Souza, CS
   Boery, RNSD
   Pires, CGD
   Souza, AD
   Rocha, RM
AF de Araujo, Wilkslam Alves
   Cardoso Santos, Isleide Santana
   Rosa, Randson Souza
   Cruz, Diego Pires
   Souza, Cicero Santos
   Silva de Oliveira Boery, Rita Narriman
   da Silva Pires, Claudia Geovana
   Souza, Andrea dos Santos
   Rocha, Roseanne Montargil
TI Educational intervention on perceived stress among adults with type 2
   diabetes and metabolic syndrome: a non-randomized clinical trial
SO INVESTIGACION Y EDUCACION EN ENFERMERIA
LA English
DT Article
DE diabetes mellitus; type 2; community health nursing; stress,
   psychological; health promotion; metabolic syndrome
ID VALIDATION; CORTISOL; SCALE; WOMEN
AB Objective. To assess the effectiveness of an educational intervention on perceived stress and metabolic syndrome parameters among adults with type 2 diabetes mellitus. Method. Fifty-one adults (aged 48.73 +/- 7.84; 86.3% of women) were included in a non-randomized clinical trial performed in a healthcare unit for six months (Brazilian Clinical Trial Registry: RBR-43K52N). All participants were diagnosed with type 2 diabetes mellitus and metabolic syndrome (intervention group, n=26; control group, n=25). The intervention consisted of a nurse-led educational health-promoting program with a multidisciplinary approach organized in seven workshops. The primary outcome was decreased perceived stress, and the secondary outcome was improvement in metabolic syndrome parameters according to perceived stress levels. These outcomes were assessed at two points in time, at the baseline and follow-up. Results. Participation in the intervention program resulted in a significant decrease in perceived stress (p=0.028). The stressed participants in the intervention group experienced a significant decrease in blood glucose levels (p=0.001) and a significant increase in high-density lipoproteincholesterol (p=0.003) concentrations after the six-month intervention. Conclusion. The nurse-led educational health-promoting program decreased perceived stress among adults with type 2 diabetes mellitus and metabolic syndrome, improving fasting blood glucose and high-density lipoprotein cholesterol among the stressed participants in the intervention group.
C1 [de Araujo, Wilkslam Alves; Cardoso Santos, Isleide Santana; Cruz, Diego Pires; Souza, Cicero Santos; Silva de Oliveira Boery, Rita Narriman; Souza, Andrea dos Santos; Rocha, Roseanne Montargil] Univ Estadual Sudoeste Bahia, Grad Program Nursing & Hlth, Candeias, BA, Brazil.
   [Rosa, Randson Souza] Univ Estadual Feira de Santana, Grad Program Collect Hlth, Novo Horizonte, BA, Brazil.
   [da Silva Pires, Claudia Geovana] Univ Fed Bahia, Grad Program Nursing & Hlth, Salvador, BA, Brazil.
C3 Universidade Estadual do Sudoeste da Bahia; Universidade Estadual de
   Feira de Santana; Universidade Federal da Bahia
RP de Araújo, WA (corresponding author), Univ Estadual Sudoeste Bahia, Grad Program Nursing & Hlth, Candeias, BA, Brazil.
EM wilkslam@hotmail.com; isantana@uesb.edu.br; enfrandson@gmail.com;
   diego_pcruz@hotmail.com; cicerossz@hotmail.com; rboery@gmail.com;
   cgspires@ufba.br; assouza@uesc.br; rmrocha@uesc.br
RI Pires, Claudia/ABC-3394-2022; Souza Rosa, Randson/AAL-1922-2020; Alves
   de Araujo, Wilkslam/G-4442-2018
OI PIRES, CLAUDIA GEOVANA DA SILVA/0000-0001-9309-2810; Souza Rosa,
   Randson/0000-0001-7093-0578; Alves de Araujo,
   Wilkslam/0000-0002-3323-4650; Pires Cruz, Diego/0000-0001-9151-9294;
   Santos, Isleide Santana Cardoso/0000-0001-8671-8686; Rocha,
   Roseanne/0000-0001-5766-413X; Boery, Rita Narriman Silva de
   Oliveira/0000-0002-7823-9498
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NR 23
TC 2
Z9 2
U1 5
U2 10
PU UNIV ANTIOQUIA, FAC ENFERMERIA
PI MEDELLIN
PA CALLE 64 N 53-09, APARTADO 1226, MEDELLIN, 00000, COLOMBIA
SN 0120-5307
EI 2216-0280
J9 INVESTIG EDUC ENFERM
JI Investig. Educ. Enferm.
PD JAN-APR
PY 2024
VL 42
IS 1
AR e03
DI 10.17533/udea.iee.v42n1e03
PG 16
WC Nursing
WE Emerging Sources Citation Index (ESCI)
SC Nursing
GA WY8Z7
UT WOS:001258539000003
PM 39083815
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Landén, M
   Baghaei, F
   Rosmond, R
   Holm, G
   Björntorp, P
   Eriksson, E
AF Landén, M
   Baghaei, F
   Rosmond, R
   Holm, G
   Björntorp, P
   Eriksson, E
TI Dystipiclemia and high waist-hip ratio in women with self-reported
   social anxiety
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE phobic disorders; anthropometry; lipids; metabolic syndrome X
ID BODY-FAT DISTRIBUTION; CORONARY-HEART-DISEASE; PSYCHIATRIC ILL-HEALTH;
   CARDIOVASCULAR-DISEASE; CORTISOL SECRETION; CHOLESTEROL CONCENTRATIONS;
   PSYCHOSOCIAL FACTORS; ARTERY-DISEASE; PANIC DISORDER; PHOBIC ANXIETY
AB Previous research has indicated that phobic anxiety is associated with coronary heart disease. In this study, the possible association between social anxiety and various anthropometric, metabolic, and endocrine measurements known to be associated with cardiovascular disease were studied in a population-based cohort of 216 women 41-42 years old. Each participant was assessed by means of a DSM-IV based self-report questionnaire regarding social anxiety and related psychiatric diagnoses. Waist-to-hip ratio (WHR), body mass index (BMI), and serum levels of lipids and hormones were assessed. The prevalence of social anxiety was 14% (n = 31). The social anxiety group displayed higher serum levels of triglycerides (1.3 +/- 0.9 vs. 1.0 +/- 0.5, P = 0.003) and low-density lipoprotein (LDL) (3.3 +/- 0.8 vs. 3.0 +/- 0.7, P = 0.03), but lower high-density lipoprotein (HDL) (1.4 +/- 0.3 vs. 1.6 +/- 0.4, P = 0.04) and HDL/LDL ratio (0.46 +/- 0.15 vs. 0.57 +/- 022, P = 0.008) than the other women. Serum levels of total testosterone (1.6 0.8 vs. 2.2 +/- 1.1, P = 0.013) and free thyroxin (141 +/- 2 vs. 16 +/- 14, P = 0.04) were tower in subjects confirming social anxiety. While WHIR was significantly higher in the social anxiety group (0.83 +/- 0.06 vs. 0.80 +/- 0.07, P = 0.016), BMI did not differ between the groups. Our data suggest that self-reported social anxiety is associated with two established risk factors for cardiovascular disease: dyslipidemia and increased WHR. (C) 2003 Elsevier Ltd. All rights reserved.
C1 Univ Gothenburg, Sahlgrens Univ Hosp, Inst Clin Neurosci, Dept Psychiat, SE-43180 Molndal, Sweden.
   Gothenburg Univ, Inst Heart & Lung Dis, S-41124 Gothenburg, Sweden.
   Gothenburg Univ, Dept Clin Chem, S-41124 Gothenburg, Sweden.
   Gothenburg Univ, Dept Pharmacol, S-41124 Gothenburg, Sweden.
C3 Sahlgrenska University Hospital; University of Gothenburg; University of
   Gothenburg; University of Gothenburg; University of Gothenburg
RP Univ Gothenburg, Sahlgrens Univ Hosp, Inst Clin Neurosci, Dept Psychiat, SE-43180 Molndal, Sweden.
EM mikaet.tanden@neuro.gu.se
RI Baghaei, Fariba/HRD-7493-2023; Landen, Mikael/AAD-7917-2020
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NR 68
TC 33
Z9 34
U1 0
U2 6
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
EI 1873-3360
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD SEP
PY 2004
VL 29
IS 8
BP 1037
EP 1046
DI 10.1016/j.psyneuen.2003.10.006
PG 10
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA 838GS
UT WOS:000222702100009
PM 15219655
DA 2025-06-11
ER

PT J
AU Jam, IN
   Sahebkar, AH
   Eslami, S
   Mokhber, N
   Nosrati, M
   Khademi, M
   Foroutan-Tanha, M
   Ghayour-Mobarhan, M
   Hadizadeh, F
   Ferns, G
   Abbasi, M
AF Jam, Irandokht Nikbakht
   Sahebkar, Amir Hossein
   Eslami, Saeid
   Mokhber, Naghmeh
   Nosrati, Mina
   Khademi, Mohammad
   Foroutan-Tanha, Mojtaba
   Ghayour-Mobarhan, Majid
   Hadizadeh, Farzin
   Ferns, Gordon
   Abbasi, Masoumeh
TI The effects of crocin on the symptoms of depression in subjects with
   metabolic syndrome
SO ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE
LA English
DT Article
DE crocin; metabolic syndrome; depression; saffron
ID PROOXIDANT-ANTIOXIDANT BALANCE; MAJOR DEPRESSION; OXIDATIVE STRESS;
   SATIVUS L.; METAANALYSIS; POPULATION; OBESITY; RISK
AB Background. Studies have suggested that metabolic syndrome (MetS) is associated with increased depressive symptoms, and reducing depression in subjects with MetS is important. Crocin, an active component of saffron, has useful properties for subjects with MetS, including antidepressant properties.
   Objectives. The aim of the study was to assess the effect of a preparation of crocin on the symptoms of depression in subjects with MetS, and the relationship between changes in those symptoms and the serum pro-oxidant/anti-oxidant balance (PAB).
   Material and methods. This sub-study was carried out on 34 subjects with MetS from the authors' previous randomized double-blind controlled clinical trial (RCT), all of whom met the inclusion criteria for this study. The subjects were randomly assigned to treatment and placebo groups (n = 17 in each group) and received each 30 mg of crocin (2 tablets of 15 mg) or placebo for 8 weeks. Depressive symptoms were assessed using the Beck Depression Inventory (BDI). The BDI questionnaire was completed for each subject at the baseline and at the end of the 8th week of treatment. Blood samples were taken from the subjects before and after the intervention period. Statistical analyses were performed using the SPSS for Windows, v. 16 (SPSS Inc., Chicago, USA).
   Results. Out of the 34 participants enrolled, 33 completed the trial. The degree of depression decreased significantly in the crocin group (p = 0.005), but not in the placebo group (p > 0.05), and the difference between the 2 groups was statistically significant (p = 0.013). No significant relationship was observed between changes in depression symptoms and changes in the serum PAB (p > 0.05).
   Conclusions. This study demonstrates that at a dose of 30 mg per day for 8 weeks, crocin reduced the symptoms of depression in subjects with MetS compared to the control group, and this effect was independent of its effect on the serum PAB.
C1 [Jam, Irandokht Nikbakht; Nosrati, Mina; Ghayour-Mobarhan, Majid] Mashhad Univ Med Sci, Sch Med, Metab Res Ctr, Mashhad, Iran.
   [Sahebkar, Amir Hossein; Hadizadeh, Farzin] Mashhad Univ Med Sci, Sch Pharm, Biotechnol Res Ctr, Mashhad, Iran.
   [Eslami, Saeid; Khademi, Mohammad; Foroutan-Tanha, Mojtaba] Mashhad Univ Med Sci, Sch Pharm, Pharmaceut Res Ctr, Mashhad, Iran.
   [Mokhber, Naghmeh] Mashhad Univ Med Sci, Sch Med, Psychiat & Behav Sci Res Ctr, Mashhad, Iran.
   [Ferns, Gordon] Univ Brighton, Div Med Educ, Brighton & Sussex Med Sch, Mayfield House, Brighton, Staffs, England.
   [Abbasi, Masoumeh] Mashhad Univ Med Sci, Sch Med, Qaem Hosp Cardiol Dept, Mashhad, Iran.
C3 Mashhad University of Medical Sciences; Mashhad University of Medical
   Sciences; Mashhad University of Medical Sciences; Mashhad University of
   Medical Sciences; University of Brighton; University of Sussex; Mashhad
   University of Medical Sciences
RP Ghayour-Mobarhan, M (corresponding author), Mashhad Univ Med Sci, Sch Med, Metab Res Ctr, Mashhad, Iran.; Hadizadeh, F (corresponding author), Mashhad Univ Med Sci, Sch Pharm, Biotechnol Res Ctr, Mashhad, Iran.
EM GhayourM@mums.ac.ir; HadizadehF@mums.ac.ir
RI Ghayour-Mobarhan, Majid/AAY-5963-2020; Sahebkar,
   Amirhossein/B-5124-2018; Hadizadeh, Farzin/AAG-2067-2019; Eslami,
   Saeid/AAZ-6005-2020
FU Mashhad University of Medical Science (MUMS), Iran
FX The authors thank the subjects who participated in this study. This work
   was supported by Mashhad University of Medical Science (MUMS), Iran.
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NR 27
TC 44
Z9 44
U1 0
U2 16
PU WROCLAW MEDICAL UNIV
PI WROCLAW
PA UL K MARCINKOWSKIEGO 2-6, WROCLAW, 50-368, POLAND
SN 1899-5276
EI 2451-2680
J9 ADV CLIN EXP MED
JI Adv. Clin. Exp. Med.
PD SEP
PY 2017
VL 26
IS 6
BP 925
EP 930
DI 10.17219/acem/62891
PG 6
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA FQ6BH
UT WOS:000418447200005
PM 29068592
OA gold
DA 2025-06-11
ER

PT J
AU Lazary, J
   Juhasz, G
   Hunyady, L
   Bagdy, G
AF Lazary, Judit
   Juhasz, Gabriella
   Hunyady, Laszlo
   Bagdy, Gyorgy
TI Personalized medicine can pave the way for the safe use of
   CB1 receptor antagonists
SO TRENDS IN PHARMACOLOGICAL SCIENCES
LA English
DT Review
ID SEROTONIN TRANSPORTER GENE; CARDIOMETABOLIC RISK-FACTORS; PROMOTER
   POLYMORPHISM 5-HTTLPR; CANNABINOID RECEPTOR; 5-HT2C RECEPTOR;
   M-CHLOROPHENYLPIPERAZINE; SEEKING BEHAVIOR; INVERSE AGONIST;
   ENDOCANNABINOID SYSTEM; BASOLATERAL AMYGDALA
AB Antagonists of cannabinoid type-1 (CB1) receptors have been explored as therapeutic agents for obesity and addiction. However, use of rimonabant (the first marketed CB, receptor antagonist) has been suspended due to its anxiogenic and depressive side effects (including suicide risk). Recent genomic studies provide evidence that variants of the CB1 receptor gene (CNR1) alone or in combination with the gene of the serotonin transporter (SLC6A4) contribute to the development of anxiety and/or depression, suggesting that high-risk individuals could be identified through genetic testing. In this review, we argue that identification of high-risk individuals by a combination of genomic screening, previous risk phenotype, and environmental risk factors offers a promising method for the safe use of centrally acting CB1 receptor antagonists. We summarize endocannabinoid signaling in pathways related to anxiety and depression, identify the serotonergic system as the most likely candidate to mediate the side effects of CB1 receptor antagonists, and propose that poloymorphisms in CNR1, SLC6A4 and certain CYP 450 enzymes could help to identify individuals who may benefit from treatment with CB(1)receptor antagonist without psychiatric side effects.
C1 [Bagdy, Gyorgy] Semmelweis Univ, Dept Pharmacodynam, Budapest, Hungary.
   Semmelweis Univ, Kutvolgyi Clin Ctr, Budapest, Hungary.
   [Juhasz, Gabriella] Univ Manchester, Sch Community Based Med, Neurosci & Psychiat Unit, Manchester M13 9PL, Lancs, England.
   [Hunyady, Laszlo] Semmelweis Univ, Dept Physiol, Budapest, Hungary.
   [Hunyady, Laszlo] Semmelweis Univ, Lab Neurobiochem & Mol Physiol, Budapest, Hungary.
   [Hunyady, Laszlo; Bagdy, Gyorgy] Hungarian Acad Sci, Budapest, Hungary.
   [Bagdy, Gyorgy] Semmelweis Univ, Dept Pharmacodynam, Budapest, Hungary.
   [Bagdy, Gyorgy] Semmelweis Univ, Grp Neurochem, Budapest, Hungary.
   [Bagdy, Gyorgy] Semmelweis Univ, Grp Neuropsychopharmacol, Budapest, Hungary.
C3 Semmelweis University; Semmelweis University; University of Manchester;
   Semmelweis University; Semmelweis University; Hungarian Academy of
   Sciences; Semmelweis University; Semmelweis University; Semmelweis
   University
RP Bagdy, G (corresponding author), Semmelweis Univ, Dept Pharmacodynam, Budapest, Hungary.
EM bag13638@iif.hu
RI Juhasz, Gabriella/O-1753-2017; Bagdy, Gyorgy/O-3893-2017
OI Juhasz, Gabriella/0000-0002-5975-4267; Bagdy, Gyorgy/0000-0001-8141-3410
FU EU [LSHM-CT-2004-503474, TAMOP-4.2.1.B-09/1/KMR-2010-0001]; OTKA [NK
   72661, ETT 318/04112009]; NIHR Manchester Biomedical Research Centre
FX Related works included in the review were supported by the Sixth
   Framework Program of the EU, LSHM-CT-2004-503474,
   TAMOP-4.2.1.B-09/1/KMR-2010-0001, OTKA NK 72661, ETT 318/04112009 and by
   the NIHR Manchester Biomedical Research Centre.
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NR 109
TC 57
Z9 63
U1 0
U2 15
PU ELSEVIER SCIENCE LONDON
PI LONDON
PA 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND
SN 0165-6147
EI 1873-3735
J9 TRENDS PHARMACOL SCI
JI Trends Pharmacol. Sci.
PD MAY
PY 2011
VL 32
IS 5
BP 270
EP 280
DI 10.1016/j.tips.2011.02.013
PG 11
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Pharmacology & Pharmacy
GA 773DK
UT WOS:000291287000002
PM 21497918
DA 2025-06-11
ER

PT J
AU Dockray, S
   Susman, EJ
   Dorn, LD
AF Dockray, Samantha
   Susman, Elizabeth J.
   Dorn, Lorah D.
TI Depression, Cortisol Reactivity, and Obesity in Childhood and
   Adolescence
SO JOURNAL OF ADOLESCENT HEALTH
LA English
DT Article
DE Depression; Cortisol; Stress; Obesity; Adolescence
ID PSYCHOSOCIAL STRESS; METABOLIC SYNDROME; WEIGHT; CHILDREN; ADULTHOOD;
   NEUROENDOCRINE; TRANSITION; OVERWEIGHT; DISORDERS; DISEASE
AB Purpose: Depression in childhood is associated with higher body mass index (BMI), a relative measure of overweight, and overweight is associated with cortisol reactivity, indexed by heightened secretion of cortisol in response to a stressor. The current study uses a mediation model to examine the associations between symptoms of depression, cortisol reactivity and BMI in a cross-sectional study.
   Methods: Children (N = 111) 8 to 13 years old and a parent completed structured interviews. The Child Behavior Checklist was used to assess symptoms of depression, and cortisol reactivity to the Trier Social Stress Test for Children was measured. Physical examinations were used to determine BMI (kg/m(2)) and pubertal stage.
   Results: Depression was positively associated with BMI in both sexes. Age and pubertal stage were not significantly associated with BMI, nor was physical activity and BMI in a model including depression. In girls, but not in boys, the association between depression and BMI was mediated by cortisol reactivity.
   Conclusions: The current findings attest to the significance of psychologic states as potential components in models of childhood obesity, and provide conceptual and empirical support for the inclusion of cortisol reactivity in these models. (C) 2009 Society for Adolescent Medicine. All rights reserved.
C1 [Dockray, Samantha] UCL, Dept Epidemiol & Publ Hlth, London WC1E, England.
   [Susman, Elizabeth J.] Penn State Univ, Dept Biobehav Hlth, University Pk, PA 16802 USA.
   [Dorn, Lorah D.] Cincinnati Childrens Hosp Med Ctr, Div Adolescent Med, Cincinnati, OH USA.
   [Dorn, Lorah D.] Univ Cincinnati, Coll Med, Cincinnati, OH USA.
C3 University of London; University College London; Pennsylvania
   Commonwealth System of Higher Education (PCSHE); Pennsylvania State
   University; Pennsylvania State University - University Park; Penn State
   Behrend; Cincinnati Children's Hospital Medical Center; University
   System of Ohio; University of Cincinnati
RP Dockray, S (corresponding author), UCL, Dept Epidemiol & Publ Hlth, 1-19 Torrington Pl, London WC1E, England.
EM s.dockray@ucl.ac.uk
RI Dockray, Samantha/B-2138-2015
OI Dockray, Samantha/0000-0002-0804-8362
FU National Institute of Mental Health [RO1 58393-03]; National Institutes
   of Health; General Clinical Research Center [M01 RR 10732]; Shibley
   Endowment; Pennsylvania State University
FX This research was supported by National Institute of Mental Health Grant
   RO1 58393-03; National Institutes of Health, General Clinical Research
   Center, Grant M01 RR 10732; and the Shibley Endowment, The Pennsylvania
   State University.
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NR 42
TC 131
Z9 177
U1 0
U2 50
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1054-139X
EI 1879-1972
J9 J ADOLESCENT HEALTH
JI J. Adolesc. Health
PD OCT
PY 2009
VL 45
IS 4
BP 344
EP 350
DI 10.1016/j.jadohealth.2009.06.014
PG 7
WC Psychology, Developmental; Public, Environmental & Occupational Health;
   Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Public, Environmental & Occupational Health; Pediatrics
GA 502AM
UT WOS:000270426200006
PM 19766938
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Al-Daghri, NM
   Al-Othman, A
   Al-Attas, OS
   Alkharfy, KM
   Alokail, MS
   Albanyan, A
   Sabico, S
   Chrousos, GP
AF Al-Daghri, Nasser M.
   Al-Othman, Abdulaziz
   Al-Attas, Omar S.
   Alkharfy, Khalid M.
   Alokail, Majed S.
   Albanyan, Abdulmajeed
   Sabico, Shaun
   Chrousos, George P.
TI Stress and cardiometabolic manifestations among Saudi students entering
   universities: a cross-sectional observational study
SO BMC PUBLIC HEALTH
LA English
DT Article
DE Stress; Cardiometabolic clustering; Saudi; Students; College life;
   Perceived stress
ID PERCEIVED STRESS; METABOLIC SYNDROME; GLOBAL MEASURE; FRESHMAN 15;
   VALIDATION; PREDICTORS; VERSION; SCALE
AB Background: In this observational study, we aimed to see whether transition in Saudi students entering university life could be a breeding stage for cardiometabolic risk factor emergence and clustering.
   Methods: A total of 1878 apparently healthy Saudi students of the Preparatory Year, King Saud University, Riyadh, KSA (1112 men and 766 women) spanning 2 academic years were included. They were divided into 2 groups based on the validated perceived stress test (PST). Anthropometrics were obtained and fasting blood samples were collected for measurement of fasting blood glucose and a lipid profile.
   Results: PST score (>27) considered indicative of stress was noted in 44.4% of students. The prevalence of this score was higher in women than in men (49.7% versus 40.7%). The prevalence of obesity, hypertension and dyslipidemia was significantly higher in men than women (p < 0.01), and this was even more apparent among stressed men, who had a significantly higher prevalence of all the above cardiometabolic factors than the non-stressed ones (p < 0.01).
   Conclusion: Perceived stress is alarmingly high among Saudi students entering universities. This study sheds light on the social responsibility of universities in promoting a healthy lifestyle, particularly in this age group, when exposure to different kinds of stressors may result in body weight and metabolic changes.
C1 [Al-Daghri, Nasser M.; Al-Othman, Abdulaziz; Al-Attas, Omar S.; Alkharfy, Khalid M.; Alokail, Majed S.; Sabico, Shaun] King Saud Univ, Coll Sci, Dept Biochem, Prince Mutaib Chair Biomarkers Osteoporosis, Riyadh 11451, Saudi Arabia.
   [Al-Daghri, Nasser M.; Al-Attas, Omar S.; Alkharfy, Khalid M.; Sabico, Shaun; Chrousos, George P.] King Saud Univ, Coll Sci, Dept Biochem, Biomarkers Res Program, Riyadh 11451, Saudi Arabia.
   [Al-Daghri, Nasser M.; Al-Attas, Omar S.; Alokail, Majed S.] King Saud Univ, Res Ctr, Ctr Excellence Biotechnol, Riyadh 11451, Saudi Arabia.
   [Al-Othman, Abdulaziz; Alokail, Majed S.] King Saud Univ, Coll Appl Med Sci, Riyadh 11451, Saudi Arabia.
   [Alkharfy, Khalid M.] King Saud Univ, Coll Pharm, Dept Clin Pharm, Riyadh 11451, Saudi Arabia.
   [Albanyan, Abdulmajeed] King Saud Univ, Riyadh 11451, Saudi Arabia.
   [Chrousos, George P.] Univ Athens, Sch Med, Dept Pediat 1, Athens 11527, Greece.
C3 King Saud University; King Saud University; King Saud University; King
   Saud University; King Saud University; King Saud University; Athens
   Medical School; National & Kapodistrian University of Athens
RP Al-Daghri, NM (corresponding author), King Saud Univ, Coll Sci, Dept Biochem, Prince Mutaib Chair Biomarkers Osteoporosis, POB 2455, Riyadh 11451, Saudi Arabia.
EM aldaghri2011@gmail.com
RI Chrousos, George/G-8702-2011; Al-okail, Majed/E-5565-2016; Alkharfy,
   Khalid/GZG-5048-2022; Al-Daghri, Nasser/A-8360-2011; Sabico,
   Shaun/C-9086-2011
OI Sabico, Shaun/0000-0002-5248-2350
FU College of Science Research Center in King Saud University, Riyadh,
   Saudi Arabia
FX This study has been funded by the College of Science Research Center in
   King Saud University, Riyadh, Saudi Arabia. The authors thank the
   students of PY and the administration for their support in this study.
   Special thanks to Mr. Benjamin Vinodson for the analysis of data.
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NR 26
TC 4
Z9 4
U1 0
U2 12
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2458
J9 BMC PUBLIC HEALTH
JI BMC Public Health
PD APR 23
PY 2014
VL 14
AR 391
DI 10.1186/1471-2458-14-391
PG 6
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA AG6BL
UT WOS:000335503300001
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Fernández-Ruiz, VE
   Paniagua-Urbano, JA
   Solé-Agustí, M
   Ruiz-Sánchez, A
   Gómez-Marín, J
   Armero-Barranco, D
AF Esperanza Fernandez-Ruiz, Virginia
   Antonio Paniagua-Urbano, Jose
   Sole-Agusti, Maria
   Ruiz-Sanchez, Alfonso
   Gomez-Marin, Jose
   Armero-Barranco, David
TI Impact of the I<SUP>2</SUP>AO<SUP>2</SUP> interdisciplinary program led
   by nursing on psychological comorbidity and quality of life: Randomized
   controlled clinical trial
SO ARCHIVES OF PSYCHIATRIC NURSING
LA English
DT Article
DE Health-related quality of life; Anxiety; Obesity; Multi-professional
   practice; Nursing
ID WEIGHT-LOSS PROGRAM; BODY-MASS INDEX; METABOLIC SYNDROME; STYLE
   INTERVENTION; BLOOD-PRESSURE; OBESE ADULTS; ASSOCIATION; HEALTH;
   ANXIETY; RISK
AB Objective: Obesity is an entity of highly prevalent multifactorial origin with associated metabolic and psychological comorbidity, causing a negative impact on the quality of life of those who suffer from it. The objective is to evaluate the impact of an interdisciplinary program for nurse-led obesity on quality of life related to health and anxiety.
   Methods: Randomized controlled clinical trial with a sample of 74 subjects diagnosed with obesity (EG: n = 37; CG: n = 37). The intervention consisted of a 12-month interdisciplinary program (with pre-test, 12 month and 24 month follow-up) coordinated by nurses.
   Results: The anxiety analysis shows that there is no effect of the intervention on S-STAI (F2; 144 = 0.246; p = 0.782), which has increased in both groups. However, there is an effect on T-STAI (F2; 144 = 8872; p < 0.001), which only increases in the control group. The interdisciplinary program has significantly improved health-related quality of life (SF-36), both in physical health parameters as well as in mental health.
   Conclusion: The interdisciplinary program led by nursing professionals has improved the quality of life related to health and has prevented the increase of anxiety-trait in participants, maintaining the long-term effects.
C1 [Esperanza Fernandez-Ruiz, Virginia; Antonio Paniagua-Urbano, Jose; Sole-Agusti, Maria; Ruiz-Sanchez, Alfonso; Gomez-Marin, Jose] Murcia Healthcare Serv, Murcia, Spain.
   [Armero-Barranco, David] Univ Murcia, Fac Nursing, Murcia, Spain.
C3 University of Murcia
RP Fernández-Ruiz, VE (corresponding author), Pl Iglesia S-N, Murcia 30163, Spain.
EM virginiaesperanza.fernandez@um.es
OI Fernandez-Ruiz, VE/0000-0002-3976-3967
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NR 79
TC 3
Z9 3
U1 0
U2 4
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0883-9417
EI 1532-8228
J9 ARCH PSYCHIAT NURS
JI Arch. Psychiatr. Nurs.
PD APR
PY 2018
VL 32
IS 2
BP 268
EP 277
DI 10.1016/j.apnu.2017.11.014
PG 10
WC Nursing; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Psychiatry
GA GB6ML
UT WOS:000429183200016
PM 29579523
DA 2025-06-11
ER

PT J
AU Russo, M
   Santarelli, D
   Georgius, P
   Austin, PJ
AF Russo, Marc
   Santarelli, Danielle
   Georgius, Peter
   Austin, Paul J.
TI A Review of Etiological Biomarkers for Fibromyalgia and Their
   Therapeutic Implications
SO PAIN PHYSICIAN
LA English
DT Review
DE Fibromyalgia; biomarkers; inflammation; innate immune response;
   metabolic syndrome; dysbiosis; etiology
ID HEPATOCYTE GROWTH-FACTOR; PITUITARY-ADRENAL AXIS; BODY-MASS INDEX; GUT
   MICROBIOTA; CERVICAL MYELOPATHY; METABOLIC SYNDROME; FATIGUE-SYNDROME;
   OBESITY; SERUM; INFLAMMATION
AB Background: Fibromyalgia is a complex condition that has long puzzled the medical community. Hypotheses to explain the chronic widespread pain associated with the disease have evolved significantly over the years. However, research efforts to identify disease-specific biomarkers and develop effective treatments have been largely unsuccessful. Objectives: The goals of this study were to review potential etiological biomarkers for fibromyalgia, focusing on micro-inflammation and metabolic syndrome, and to discuss the clinical implications of the review findings. Study Design: A narrative review. Methods: Relevant literature was obtained via Medline/PubMed, using the following search terms: fibromyalgia[ti] ("metabolic syndrome" OR "metabolic disease" OR biomarker*[ti] OR micro-inflammation OR sub-inflammation OR "low-level inflammation" OR "low-grade inflammation"). Results were filtered for the English language and screened for inclusion in the review. Results: Articles included in the review covered the topics of pain, immune response/inflammation, micro-inflammation, metabolic syndrome, gut dysbiosis, oxidative stress, and stress response. Various molecules have been proposed as pain biomarkers for fibromyalgia, including neurotransmitters, neuropeptides, growth factors, and cytokines with possible etiological relevance. Recent genome-wide expression profiling suggests connections among low-level inflammation, termed "micro-inflammation," and the upregulation of genes involved in antibacterial and innate immune system response as well as those involved in clinical features, including high body mass index (BMI) and comorbid depression, in a subgroup of fibromyalgia patients. A set of 5 differentially expressed inflammatory genes have been identified as potential biomarkers of a micro-inflammation fibromyalgia subtype. Proposed triggers of micro-inflammation include bacterial disease and gut dysbiosis. Metabolic syndrome may be causative or consequential, while comorbid depression may be associated with dysbiosis and/or micro-inflammation through the gut-immune-brain axis. A potential new treatment approach based on this information has been proposed. Limitations: External validation of potential etiological biomarkers is needed. Further investigations to ascertain the involvement of metabolic syndrome and gut dysbiosis and support the proposed treatment paradigm are warranted. Conclusion: Fibromyalgia is likely the result of multiple causative factors, genetic and environmental. To date, no clear, reliable etiological biomarker for fibromyalgia has been identified. The considerable variability among patients suggests the presence of multiple disease subtypes with different pathophysiological mechanisms. Effective treatment therefore requires a multimodal, multidisciplinary approach that targets each individual patient's pathophysiological features. The proposed treatment paradigm attempts to address multiple factors that have been implicated more recently in the development and maintenance of fibromyalgia, such as micro-inflammation, metabolic syndrome, and gut dysbiosis.
C1 [Russo, Marc] Hunter Pain Specialists, 91 Chatham St, Broadmeadows, NSW 2292, Australia.
   [Russo, Marc] Genesis Res Serv, Broadmeadows, NSW, Australia.
   [Russo, Marc] Univ Newcastle, Coll Hlth Med & Wellbeing, Sch Biomed Sci & Pharm, Callaghan, NSW, Australia.
   Pain Rehab, Noosa Heads, Qld, Australia.
   Univ Sydney, Fac Med & Hlth, Brain & Mind Ctr, Sch Med Sci, Camperdown, NSW, Australia.
C3 University of Newcastle; University of Sydney
RP Russo, M (corresponding author), Hunter Pain Specialists, 91 Chatham St, Broadmeadows, NSW 2292, Australia.
EM algoguy@gmail.com
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NR 108
TC 1
Z9 1
U1 2
U2 2
PU AM SOC INTERVENTIONAL PAIN PHYSICIANS
PI PADUCAH
PA 81 LAKEVIEW DR, PADUCAH, KY 42001 USA
SN 1533-3159
J9 PAIN PHYSICIAN
JI Pain Physician
PD NOV
PY 2024
VL 27
IS 8
BP 495
EP 506
PG 12
WC Anesthesiology; Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Anesthesiology; Neurosciences & Neurology
GA O4K4X
UT WOS:001370836100004
PM 39621974
DA 2025-06-11
ER

PT J
AU Lofrano-Prado, MC
   Antunes, HKM
   do Prado, WL
   de Piano, A
   Caranti, DA
   Tock, L
   Carnier, J
   Tufik, S
   de Mello, MT
   Dâmaso, AR
AF Lofrano-Prado, Mara Cristina
   Moreira Antunes, Hanna Karen
   do Prado, Wagner Luiz
   de Piano, Aline
   Caranti, Danielle Arisa
   Tock, Lian
   Carnier, June
   Tufik, Sergio
   de Mello, Marco Tulio
   Damaso, Ana R.
TI Quality of life in Brazilian obese adolescents: effects of a long-term
   multidisciplinary lifestyle therapy
SO HEALTH AND QUALITY OF LIFE OUTCOMES
LA English
DT Article
ID WEIGHT-LOSS; METABOLIC SYNDROME; EATING-DISORDER; RISK-FACTORS;
   BODY-IMAGE; FOLLOW-UP; OVERWEIGHT; INTERVENTION; DEPRESSION; EXERCISE
AB Background: Obesity has adverse physical, social, and economic consequences that can negatively affect quality of life (QOL). Thus the aim of this study was to verify the effects of a long-term multidisciplinary lifestyle intervention on QOL, body image, anxiety, depression and binge eating in obese adolescents.
   Methods: Sixty-six obese adolescents (41 girls and 25 boys; BMI: 35.62 +/- 4.18 kg/m(2)) were recruited from the Multidisciplinary Obesity Intervention Program outpatient clinic, and were submitted to a multidisciplinary lifestyle therapy (short-term = 12 weeks and long-term = 24 weeks), composed of medical, dietary, exercise and psychological programs. Validated self-report questionnaires were used to assess symptoms of anxiety Trait/State (STAI); depression (BDI); binge eating (BES), body image dissatisfaction (BSQ) and QOL (SF-36). Data were analyzed by means of scores; comparisons were made by ANOVA for repeated measures, and Tukey's test as post-hoc and Students T test.
   Results: Long-term therapy decreased depression and binge eating symptoms, body image dissatisfaction, and improved QOL in girls, whereas, for boys, 24 weeks, were effective to reduce anxiety trait/state and symptoms of binge eating, and to improve means of dimensions of QOL (p <.05).
   Conclusion: A long-term multidisciplinary lifestyle therapy is effective to control psychological aspects and to improve QOL in obese adolescents.
C1 [Lofrano-Prado, Mara Cristina; de Piano, Aline; Caranti, Danielle Arisa; Tock, Lian; Carnier, June; de Mello, Marco Tulio; Damaso, Ana R.] Univ Fed Sao Paulo, Paulista Sch Med, Post Grad Program Nutr, Sao Paulo, Brazil.
   [Moreira Antunes, Hanna Karen; Damaso, Ana R.] Univ Fed Sao Paulo, Dept Hlth Sci, Santos, SP, Brazil.
   [do Prado, Wagner Luiz] Univ Fed Pernambuco, Dept Phys Educ, Recife, PE, Brazil.
   [Tufik, Sergio; de Mello, Marco Tulio] Univ Fed Sao Paulo, Paulista Sch Med, Dept Psychobiol, Sao Paulo, Brazil.
C3 Universidade Federal de Sao Paulo (UNIFESP); Universidade Federal de Sao
   Paulo (UNIFESP); Universidade Federal de Pernambuco; Universidade
   Federal de Sao Paulo (UNIFESP)
RP Lofrano-Prado, MC (corresponding author), Univ Fed Sao Paulo, Paulista Sch Med, Post Grad Program Nutr, Marselhesa St 535, Sao Paulo, Brazil.
EM maralofrano@gmail.com; hannakaren@psicobio.epm.br; wagner.prado@upe.br;
   aline.depiano@mail.com; danielle@caranti.com.br; lionto@uol.com.br;
   junecarnier@hotmail.com; stufk@psicobio.epm.br; tmello@psicobio.epm.br;
   ana.damaso@unifesp.br
RI Tufik, Sergio/D-7606-2012; Dâmaso, Ana/AAT-6058-2021; Prado,
   Wagner/N-3158-2016; Lofrano-Prado, Mara Cristina/Y-5628-2019; Antunes,
   Hanna Karen/C-8070-2012; de Mello, Marco Tulio/G-3237-2010; de Piano,
   Aline/J-8334-2016
OI Prado, Wagner/0000-0001-5046-4522; Lofrano-Prado, Mara
   Cristina/0000-0002-8296-3024; Antunes, Hanna Karen/0000-0001-6648-0957;
   de Mello, Marco Tulio/0000-0003-3896-2208; Arisa Caranti,
   Danielle/0000-0002-2679-2945; de Piano, Aline/0000-0001-6433-0816
FU AFIP; CNPq; CAPES; CENESP; FADA; FAPESP [9814303-3]; UNIFESP; CEPE-GEO
   Multidisciplinary Obesity Intervention Program
FX AFIP, CNPq, CAPES, CENESP, FADA, FAPESP (CEPID/Sleep # 9814303-3 S. T),
   FAPESP (2008/53069-0) and UNIFESP supported the CEPE-GEO
   Multidisciplinary Obesity Intervention Program. Special thanks to
   patients and their parents.
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NR 53
TC 49
Z9 53
U1 0
U2 16
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1477-7525
J9 HEALTH QUAL LIFE OUT
JI Health Qual. Life Outcomes
PD JUL 3
PY 2009
VL 7
AR 61
DI 10.1186/1477-7525-7-61
PG 8
WC Health Care Sciences & Services; Health Policy & Services
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services
GA 472YQ
UT WOS:000268169800001
PM 19575801
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Copeland, WE
   Shanahan, L
   Worthman, C
   Angold, A
   Costello, EJ
AF Copeland, W. E.
   Shanahan, L.
   Worthman, C.
   Angold, A.
   Costello, E. J.
TI Generalized anxiety and C-reactive protein levels: a prospective,
   longitudinal analysis
SO PSYCHOLOGICAL MEDICINE
LA English
DT Article
DE Adolescence; childhood; C-reactive protein; epidemiology; generalized
   anxiety disorder; inflammation
ID DEXAMETHASONE-SUPPRESSION TEST; FOR-DISEASE-CONTROL; MAJOR DEPRESSION;
   RISK-FACTORS; PSYCHIATRIC-DISORDERS; CARDIOVASCULAR RISK; METABOLIC
   SYNDROME; INFLAMMATION; SYMPTOMS; CHILDHOOD
AB Background. Generalized anxiety disorder (GAD) is highly co-morbid with depression. Depression is associated with elevated levels of the inflammation marker C-reactive protein (CRP), cross-sectionally and over time. To date, no studies have looked at the association between CRP and GAD.
   Method. A total of nine waves of data from the prospective population-based Great Smoky Mountains Study (n=1420) were used, covering children in the community aged 9-16, 19 and 21 years old. Structured interviews were used at each assessment to assess GAD symptoms, diagnosis and cumulative episodes. Blood spots were collected and assayed for high-sensitivity CRP levels.
   Results. GAD was associated with increased levels of CRP in bivariate cross-sectional analyses. These bivariate associations, however, were attenuated after accounting for demographic, substance-use and health-related covariates. In longitudinal models, there was little evidence that CRP predicted later GAD. Associations from GAD to later CRP were attenuated in models adjusted for health-related coavariates and there was evidence that the GAD-CRP association was mediated by body mass index (BMI) and medication use.
   Conclusions. Similar to depression, GAD was associated with elevated levels of CRP, but the effect of GAD on CRP levels was explained by the effect of GAD on health-related behaviors such as BMI and medication use. This study suggests differences in the association between inflammation and depression and GAD.
C1 [Copeland, W. E.] Duke Univ, Med Ctr, Dept Psychiat & Behav Sci, Durham, NC 27710 USA.
   [Shanahan, L.] Univ N Carolina, Chapel Hill, NC USA.
   [Worthman, C.] Emory Univ, Atlanta, GA 30322 USA.
C3 Duke University; University of North Carolina; University of North
   Carolina Chapel Hill; Emory University
RP Copeland, WE (corresponding author), Duke Univ, Med Ctr, Dept Psychiat & Behav Sci, Box 3454, Durham, NC 27710 USA.
EM William.Copeland@duke.edu
RI Shanahan, Lilly/HNJ-6173-2023; Copeland, William E/N-5413-2014;
   Stefanadis, Christodoulos/ABH-2232-2020
OI Copeland, William E/0000-0002-1348-7781; Worthman, Carol
   M/0000-0002-5397-2298; Shanahan, Lilly/0000-0002-4534-6924; Stefanadis,
   Christodoulos/0000-0001-5974-6454
FU National Institute of Mental Health [MH63970, MH63671, MH48085];
   National Institute on Drug Abuse, a National Alliance for Research on
   Schizophrenia and Depression (NARSAD) Early Career Award [DA/MH11301];
   William T. Grant Foundation
FX This work was supported by the National Institute of Mental Health
   (grants no. MH63970, MH63671 and MH48085), the National Institute on
   Drug Abuse (grant no. DA/MH11301), a National Alliance for Research on
   Schizophrenia and Depression (NARSAD) Early Career Award to W. E. C. and
   the William T. Grant Foundation.
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NR 59
TC 96
Z9 110
U1 0
U2 30
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
SN 0033-2917
EI 1469-8978
J9 PSYCHOL MED
JI Psychol. Med.
PD DEC
PY 2012
VL 42
IS 12
BP 2641
EP 2650
DI 10.1017/S0033291712000554
PG 10
WC Psychology, Clinical; Psychiatry; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA 031HO
UT WOS:000310630300017
PM 22716910
OA Green Submitted, Green Accepted
DA 2025-06-11
ER

PT J
AU Morera, LP
   Marchiori, GN
   Medrano, LA
   Defagó, MD
AF Pedro Morera, Luis
   Noel Marchiori, Georgina
   Adrian Medrano, Leonardo
   Daniela Defago, Maria
TI Stress, Dietary Patterns and Cardiovascular Disease: A Mini-Review
SO FRONTIERS IN NEUROSCIENCE
LA English
DT Review
DE stress; cardiovascular disease; dietary patterns; nutrition; microbiome
ID ANXIETY-LIKE BEHAVIOR; GUT MICROBIOME; RISK-FACTORS; OBESITY; BRAIN;
   HEART; DEPRESSION; HEALTH; FOOD; PREVALENCE
AB According to the World Health Organization, an unhealthy diet and insufficient physical activity are the leading global risks to health. Dietary behavior is a modifiable factor in cardiovascular disease (CVD) prevention. Furthermore, the fact that cardiovascular events and stress-related emotional disorders share a common epidemiology may indicate the existence of pathways linking these two diseases (Chauvet-Gelinier and Bonin, 2017). Psychosocial stress can lead to changes in dietary patterns (DP) and under chronic stress conditions, high caloric and hyperpalatable foods are preferred. The interplay between these two factors impacts on several biological pathways: for example, it can prime the hippocampus to produce a potentiated neuroinflammatory response, generating memory deficits; it can also affect gut microbiota composition, ultimately influencing behavior and brain health and creating a predisposition to the development of diseases such as obesity, CVD, diabetes and metabolic syndrome. Though both cognition and emotion can be heavily affected by caloric intake, diet composition and stress, the molecular pathways involved remain elusive (Spencer et al., 2017). In this review, we describe the interplay between stress and DP at a molecular level, and how these factors relate to brain health and mental fitness. Finally, we show how these findings could give rise to novel therapeutic targets for chronic diseases.
C1 [Pedro Morera, Luis; Adrian Medrano, Leonardo] Univ Siglo 21, Inst Org Saludables, Cordoba, Argentina.
   [Noel Marchiori, Georgina; Daniela Defago, Maria] Univ Nacl Cordoba, Fac Ciencias Med, Escuela Nutr, Cordoba, Argentina.
   [Adrian Medrano, Leonardo] Pontificia Univ Catolica Madre & Maestra, Dept Pyschol, Santiago De Caballeros, Dominican Rep.
C3 National University of Cordoba; Pontificia Universidad Catolica Madre y
   Maestra
RP Morera, LP (corresponding author), Univ Siglo 21, Inst Org Saludables, Cordoba, Argentina.
EM luis.p.morera@gmail.com
RI Medrano, Leonardo/AAC-1456-2020; Morera, Luis/AAG-3734-2020
OI Defago, Maria/0000-0002-8878-3067; Medrano, Leonardo
   Adrian/0000-0002-3371-5040; Morera, Luis Pedro/0000-0002-4080-544X;
   Marchiori, Georgina Noel/0000-0001-8633-9598
FU Ministry of Science and Technology of Cordoba grant GRFT 2017;
   Universidad Siglo 21; SECyT Secretary of Science and Technology of the
   National University of Cordoba (SECyT)
FX This work was supported by the Ministry of Science and Technology of
   Cordoba grant GRFT 2017, Universidad Siglo 21 and SECyT Secretary of
   Science and Technology of the National University of Cordoba (SECyT).
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NR 67
TC 22
Z9 30
U1 0
U2 20
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1662-453X
J9 FRONT NEUROSCI-SWITZ
JI Front. Neurosci.
PD NOV 12
PY 2019
VL 13
AR 1226
DI 10.3389/fnins.2019.01226
PG 7
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA JQ8KD
UT WOS:000499186500001
PM 31780892
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Shank, LM
   Neyland, MKH
   Lavender, JM
   Schindler, R
   Solomon, S
   Hennigan, K
   Leu, W
   Schvey, NA
   Sbrocco, T
   Jorgensen, S
   Stephens, M
   Olsen, CH
   Haigney, M
   Klein, DA
   Quinlan, J
   Yanovski, JA
   Tanofsky-Kraff, M
AF Shank, Lisa M.
   Neyland, M. Katy Higgins
   Lavender, Jason M.
   Schindler, Rachel
   Solomon, Senait
   Hennigan, Kathrin
   Leu, William
   Schvey, Natasha A.
   Sbrocco, Tracy
   Jorgensen, Sarah
   Stephens, Mark
   Olsen, Cara H.
   Haigney, Mark
   Klein, David A.
   Quinlan, Jeffrey
   Yanovski, Jack A.
   Tanofsky-Kraff, Marian
TI Sex differences in metabolic syndrome components in adolescent military
   dependents at high-risk for adult obesity
SO PEDIATRIC OBESITY
LA English
DT Article
DE adolescents; metabolic syndrome; military; obesity; overweight; sex
   differences
ID EXCESS WEIGHT-GAIN; BLOOD-PRESSURE; WAIST CIRCUMFERENCE;
   INSULIN-RESISTANCE; NATIONAL-HEALTH; BODY-FAT; CHILDREN; PREVALENCE;
   OVERWEIGHT; ASSOCIATIONS
AB Background Metabolic syndrome in adolescence has been associated with adverse cardiometabolic outcomes in adulthood. Preliminary data suggest that boys may have worsened metabolic syndrome components compared to girls. Yet, little is known about the physical health of military dependents, a potentially at-risk population.
   Objective Examine sex differences in metabolic syndrome components in a sample of adolescent military dependents.
   Methods Participants were adolescents (N = 139; 14.4 +/- 1.6 years; 45.3% male; 41.0% non-Hispanic White, 19.4% non-Hispanic Black; BMI-z: 1.9 +/- 0.4) at-risk for adult obesity and binge-eating disorder due to an age- and sex-adjusted BMI >= 85th percentile and loss-of-control eating and/or elevated anxiety. A multivariate analysis of covariance was conducted to compare objectively measured metabolic syndrome components across boys and girls. Covariates were age, race, loss-of-control eating status, anxiety symptoms, and BMI-z.
   Results Metabolic syndrome components differed by sex (P = .01). Boys had higher systolic blood pressure (P = .049), lower high-density lipoprotein cholesterol (P = .01), and higher glucose (P = .001) than girls. Waist circumference, diastolic blood pressure, and triglycerides did not differ between boys and girls (P > .05).
   Conclusions Future research should prospectively examine these relationships into adulthood. If the current findings are supported, prevention programs should consider targeting cardiometabolic health particularly among male adolescent military dependents.
C1 [Shank, Lisa M.; Neyland, M. Katy Higgins; Lavender, Jason M.; Schindler, Rachel; Hennigan, Kathrin; Haigney, Mark; Tanofsky-Kraff, Marian] Uniformed Serv Univ Hlth Sci USU, Dept Med, Bethesda, MD USA.
   [Shank, Lisa M.; Neyland, M. Katy Higgins; Lavender, Jason M.; Schindler, Rachel; Solomon, Senait; Hennigan, Kathrin; Haigney, Mark; Tanofsky-Kraff, Marian] Uniformed Serv Univ Hlth Sci USU, Mil Cardiovasc Outcomes Res MiCOR Program, Bethesda, MD USA.
   [Shank, Lisa M.; Neyland, M. Katy Higgins; Lavender, Jason M.; Schindler, Rachel; Hennigan, Kathrin] Metis Fdn, San Antonio, TX USA.
   [Shank, Lisa M.; Schvey, Natasha A.; Yanovski, Jack A.; Tanofsky-Kraff, Marian] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Sect Growth & Obes, Program Dev Endocrinol & Genet, NIH,DHHS, Bethesda, MD USA.
   [Solomon, Senait; Leu, William; Schvey, Natasha A.; Sbrocco, Tracy; Tanofsky-Kraff, Marian] USU, Dept Med & Clin Psychol, Bethesda, MD USA.
   [Solomon, Senait] Henry M Jackson Fdn Adv Mil Med HJF, Bethesda, MD USA.
   [Jorgensen, Sarah] Ft Belvoir Community Hosp, Ft Belvoir, VA USA.
   [Stephens, Mark] Penn State Univ, State Coll, PA USA.
   [Olsen, Cara H.] Uniformed Serv Univ Hlth Sci USU, Dept Prevent Med & Biostat, Bethesda, MD USA.
   [Klein, David A.; Quinlan, Jeffrey] Uniformed Serv Univ Hlth Sci USU, Dept Family Med, Bethesda, MD USA.
   [Klein, David A.] Malcolm Grow Med Clin & Surg Ctr, Joint Base Andrews, MD USA.
C3 National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver
   National Institute of Child Health & Human Development (NICHD); Henry M.
   Jackson Foundation for the Advancement of Military Medicine, Inc;
   Pennsylvania Commonwealth System of Higher Education (PCSHE);
   Pennsylvania State University; Pennsylvania State University -
   University Park
RP Tanofsky-Kraff, M (corresponding author), Uniformed Serv Univ Hlth Sci, Dept Med & Clin Psychol, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA.
EM marian.tanofsky-kraff@usuhs.edu
RI Stephens, Mark/A-2679-2015; Shank, Lisa/I-7079-2015
OI Quinlan, Jeffrey/0000-0001-9335-6820; Haigney, Mark/0000-0001-6449-4386;
   Shank, Lisa/0000-0002-6922-7946; Jorgensen, Sarah/0000-0003-4167-4688;
   Yanovski, Jack/0000-0001-8542-1637; , Mark/0000-0003-0156-1638
FU Defense Health Agency [MED 83-10180]; Eunice Kennedy Shriver National
   Institute of Child Health and Human Development [ZIA-HD-00641]; National
   Institute of Diabetes and Digestive and Kidney Diseases
   [1R01DK104115-01]
FX Defense Health Agency, Grant/Award Number: MED 83-10180; Eunice Kennedy
   Shriver National Institute of Child Health and Human Development,
   Grant/Award Number: ZIA-HD-00641; National Institute of Diabetes and
   Digestive and Kidney Diseases, Grant/Award Number: 1R01DK104115-01
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NR 50
TC 1
Z9 1
U1 0
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2047-6310
EI 2047-6302
J9 PEDIATR OBES
JI Pediatr. Obes.
PD AUG
PY 2020
VL 15
IS 8
AR e12638
DI 10.1111/ijpo.12638
EA APR 2020
PG 9
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Pediatrics
GA MQ3OZ
UT WOS:000526879000001
PM 32286006
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Jialal, I
   Adams-Huet, B
   Pahwa, R
AF Jialal, Ishwarlal
   Adams-Huet, Beverley
   Pahwa, Roma
TI Selective increase in monocyte p38 mitogen-activated protein kinase
   activity in metabolic syndrome
SO DIABETES & VASCULAR DISEASE RESEARCH
LA English
DT Article
DE Mitogen-activated protein kinase; inflammation; monocytes; metabolic
   syndrome
ID SKELETAL-MUSCLE; INNATE IMMUNITY; MAP KINASES; INHIBITION
AB Objective: Metabolic syndrome is a common disorder that predisposes to both cardiovascular disease and diabetes. There is paucity of data on cellular signal transduction pathways in metabolic syndrome. This study determined monocyte mitogen-activated protein kinase activity in patients with metabolic syndrome.
   Research design and methods: The p38, extracellular signal-regulated kinase-1/2 and Jun N-terminal kinase-mitogen-activated protein kinase activities were assayed in isolated monocytes from patients with metabolic syndrome and controls (n=36 per group) and correlated with features of metabolic syndrome, inflammation and oxidative stress biomarkers.
   Results: A significant increase in p38 mitogen-activated protein kinase activity was observed in metabolic syndrome even following adjustment for adiposity. There were no significant differences in extracellular signal-regulated kinase-1/2 and Jun N-terminal kinase activities. P38 mitogen-activated protein kinase activity correlated significantly with homeostasis model assessment-estimated insulin resistance and biomarkers of inflammation and oxidative stress.
   Conclusions: We are first to observe a selective increase in monocyte p38 mitogen-activated protein kinase activity in metabolic syndrome and suggest it as a pivotal molecular target for ameliorating insulin resistance and inflammation.
C1 [Jialal, Ishwarlal; Pahwa, Roma] Univ Calif Davis, Lab Atherosclerosis & Metab Res, Dept Pathol & Internal Med, Med Ctr, Sacramento, CA 95817 USA.
   [Jialal, Ishwarlal] Vet Affairs Med Ctr, Mather, CA USA.
   [Adams-Huet, Beverley] Univ Texas SW Med Ctr Dallas, Dept Biostat, Dallas, TX 75390 USA.
C3 University of California System; University of California Davis; US
   Department of Veterans Affairs; Veterans Health Administration (VHA);
   University of Texas System; University of Texas Southwestern Medical
   Center Dallas
RP Jialal, I (corresponding author), Univ Calif Davis, Lab Atherosclerosis & Metab Res, Dept Pathol & Internal Med, Med Ctr, 4635 2nd Ave,Res 1 Bldg,Room 3000, Sacramento, CA 95817 USA.
EM ijialal@ucdavis.edu
RI Jialal, Ishwarlal/AAG-6218-2019
OI Pahwa, Roma/0009-0006-0745-3581
FU ADA grant
FX This study was supported by an ADA grant (I.J.).
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NR 16
TC 12
Z9 14
U1 1
U2 6
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1479-1641
EI 1752-8984
J9 DIABETES VASC DIS RE
JI Diabetes Vasc. Dis. Res.
PD JAN
PY 2016
VL 13
IS 1
BP 93
EP 96
DI 10.1177/1479164115607829
PG 4
WC Endocrinology & Metabolism; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Cardiovascular System & Cardiology
GA CZ1ZN
UT WOS:000366904900010
PM 26449239
OA Bronze
DA 2025-06-11
ER

PT J
AU Gujral, S
   Manuck, SB
   Ferrell, RE
   Flory, JD
   Erickson, KI
AF Gujral, Swathi
   Manuck, Stephen B.
   Ferrell, Robert E.
   Flory, Janine D.
   Erickson, Kirk I.
TI The BDNF Val66Met polymorphism does not moderate the effect of
   self-reported physical activity on depressive symptoms in midlife
SO PSYCHIATRY RESEARCH
LA English
DT Article
DE Depression; Exercise; BDNF polymorphism
ID RANDOMIZED-CONTROLLED-TRIALS; MAJOR DEPRESSION; AEROBIC EXERCISE;
   ACTIVITY QUESTIONNAIRE; MEMORY PERFORMANCE; METABOLIC SYNDROME;
   MESSENGER-RNA; MENTAL-HEALTH; ADULTS; BRAIN
AB The brain-derived neurotrophic factor (BDNF) Val66Met single nucleotide polymorphism may be associated with clinical and subsyndromal depression, but physical activity improves mood and increases BDNF expression. The aim of the study was to examine whether the BDNF polymorphism moderates an effect of physical activity on depressive symptoms. BDNF genotype, physical activity measured by the Paffenbarger Questionnaire, and depressive symptoms using the Center for Epidemiology Depression Scale (CES-D) were collected on 1072 participants (mean age=44). Multiple linear regression was used to examine the association between BDNF genotype, physical activity, and depressive symptoms. After adjusting for family income, age, and education, depressive symptoms were higher in Met carriers compared to Val homozygotes (p=0.03), but this was only significant in men. Physical activity was associated with fewer depressive symptoms, but only in women (p=0.01). BDNF genotype did not moderate the effect of physical activity on depressive symptoms (p=0.94). In midlife, the BDNF Val66Met polymorphism neither attenuates nor magnifies the effect of physical activity on depressive symptoms. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
C1 [Gujral, Swathi; Manuck, Stephen B.; Erickson, Kirk I.] Univ Pittsburgh, Dept Psychol, Pittsburgh, PA 15260 USA.
   [Gujral, Swathi; Manuck, Stephen B.; Erickson, Kirk I.] Univ Pittsburgh, Ctr Neural Basis Cognit, Pittsburgh, PA USA.
   [Ferrell, Robert E.] Univ Pittsburgh, Dept Human Genet, Pittsburgh, PA USA.
   [Flory, Janine D.] Mt Sinai Sch Med, Dept Psychiat, New York, NY USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE); University
   of Pittsburgh; Pennsylvania Commonwealth System of Higher Education
   (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of
   Higher Education (PCSHE); University of Pittsburgh; Icahn School of
   Medicine at Mount Sinai
RP Erickson, KI (corresponding author), 3107 Sennott Sq,210 S Bouquet St, Pittsburgh, PA 15213 USA.
EM kiericks@pitt.edu
RI Gujral, Swathi/KIA-3430-2024; Erickson, Kirk/F-9997-2016
OI Erickson, Kirk/0000-0001-8736-981X
FU National Institutes of Health [PO1 HL040962, RO1 HL065137, RO1 DK095172]
FX This research was partially supported by National Institutes of Health
   Grants PO1 HL040962 and RO1 HL065137 to S.B. Manuck and Grant RO1
   DK095172 to K.I. Erickson.
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NR 60
TC 20
Z9 21
U1 0
U2 12
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0165-1781
J9 PSYCHIAT RES
JI Psychiatry Res.
PD AUG 15
PY 2014
VL 218
IS 1-2
BP 93
EP 97
DI 10.1016/j.psychres.2014.03.028
PG 5
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA AK7NH
UT WOS:000338614500017
PM 24745471
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Wingenfeld, K
   Kuehl, LK
   Boeker, A
   Schultebraucks, K
   Schulz, A
   Stenzel, J
   Spitzer, C
   Otte, C
AF Wingenfeld, Katja
   Kuehl, Linn K.
   Boeker, Anita
   Schultebraucks, Katharina
   Schulz, Anne
   Stenzel, Julia
   Spitzer, Carsten
   Otte, Christian
TI Are adverse childhood experiences and depression associated with
   impaired glucose tolerance in females? An experimental study
SO JOURNAL OF PSYCHIATRIC RESEARCH
LA English
DT Article
DE Childhood averse experience; Depression; Metabolic syndrome; Insulin;
   Glucose
ID PRELIMINARY PSYCHOMETRIC PROPERTIES; EARLY TRAUMA INVENTORY; EARLY-LIFE
   STRESS; METABOLIC SYNDROME; ANTIDEPRESSANT USE; GENDER-DIFFERENCES;
   PHYSICAL HEALTH; TELOMERE LENGTH; GERMAN VERSION; SEXUAL-ABUSE
AB Adverse childhood experiences (ACE) enhance the risk for mental disorders, e.g. major depressive disorder (MDD). Increasing evidence suggests an association between ACE and impaired physical health, e.g. metabolic syndrome. The aim of this study was to assess several metabolic risk markers in healthy individuals with and without ACE and depressed patients with and without ACE.
   We examined glucose and insulin release in the oGTT in 33 women with MDD and ACE, 47 women with MDD without ACE, 21 women with ACE but no current or lifetime MDD and 36 healthy women without either MDD or ACE. Several metabolic markers such as triglycerides, cholesterol, LDL, HDL, HUAI c, BMI and waist to hip ratio were assessed.
   The four groups did neither differ in insulin release and glucose concentrations in the oGTT nor with respect to other metabolic variables. Depressed patients with and without psychotropic medication did not differ in any outcome variable, but there was a trend towards higher glucose concentrations in the oGTT in patients with current psychotropic medication.
   In this physically healthy sample neither ACE nor MDD were associated with metabolic risk factors. Thus, metabolic alterations might not directly be linked to ACE and depression. (C) 2017 Elsevier Ltd. All rights reserved.
C1 [Wingenfeld, Katja; Kuehl, Linn K.; Schultebraucks, Katharina; Schulz, Anne; Stenzel, Julia; Otte, Christian] Charite Univ Med Berlin, Dept Psychiat & Psychotherapy, Hindenburgdamm 30,Campus Benjamin Franklin, D-12203 Berlin, Germany.
   [Boeker, Anita; Spitzer, Carsten] Asklepios Fachklinikum Tiefenbrunn, Rosdorf, Germany.
C3 Berlin Institute of Health; Free University of Berlin; Humboldt
   University of Berlin; Charite Universitatsmedizin Berlin
RP Wingenfeld, K (corresponding author), Charite Univ Med Berlin, Dept Psychiat & Psychotherapy, Hindenburgdamm 30,Campus Benjamin Franklin, D-12203 Berlin, Germany.
EM katja.wingenfeld@charite.de
RI Schultebraucks, Katharina/J-7216-2019
OI Kuehl, Linn/0000-0001-6871-6302; Otte, Christian/0000-0002-4051-997X;
   Wingenfeld, Katja/0000-0001-7457-0370; Schultebraucks,
   Katharina/0000-0001-5085-8249
FU Deutsche Forschungsgemeinschaft [WI 3396/6-1, SP 579/3-1]
FX The study was supported by grant of the Deutsche Forschungsgemeinschaft
   (WI 3396/6-1 & SP 579/3-1) awarded to KW, CS and CO.
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NR 65
TC 6
Z9 6
U1 0
U2 9
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-3956
EI 1879-1379
J9 J PSYCHIATR RES
JI J. Psychiatr. Res.
PD DEC
PY 2017
VL 95
BP 60
EP 67
DI 10.1016/j.jpsychires.2017.07.028
PG 8
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA FN1UQ
UT WOS:000415777100009
PM 28783579
DA 2025-06-11
ER

PT J
AU McCurley, JL
   Mills, PJ
   Roesch, SC
   Carnethon, M
   Giacinto, RE
   Isasi, CR
   Teng, YP
   Sotres-Alvarez, D
   Llabre, MM
   Penedo, FJ
   Schneiderman, N
   Gallo, LC
AF McCurley, Jessica L.
   Mills, Paul J.
   Roesch, Scott C.
   Carnethon, Mercedes
   Giacinto, Rebeca E.
   Isasi, Carmen R.
   Teng, Yanping
   Sotres-Alvarez, Daniela
   Llabre, Maria M.
   Penedo, Frank J.
   Schneiderman, Neil
   Gallo, Linda C.
TI Chronic stress, inflammation, and glucose regulation in US Hispanics
   from the HCHS/SOL Sociocultural Ancillary Study
SO PSYCHOPHYSIOLOGY
LA English
DT Article
DE Stress; Glucose; Insulin; Hispanic; Inflammation
ID C-REACTIVE PROTEIN; CARDIOVASCULAR-DISEASE; INSULIN-RESISTANCE;
   RISK-FACTORS; PERCEIVED STRESS; PSYCHOLOGICAL STRESS; DEPRESSIVE
   SYMPTOMS; METABOLIC SYNDROME; HEALTH; PREVALENCE
AB Diabetes prevalence is rising rapidly, and diabetes disproportionately affects Hispanics and other underserved groups. Chronic stress may contribute to diabetes risk, but few studies have examined this relationship in U.S. Hispanics. We examined associations of chronic stress with fasting glucose, glucose tolerance, and glycosylated hemoglobin (HbA1c) in Hispanics without diabetes, and also assessed indirect effects of stress through inflammation (CRP). Participants were 3,923 men and women, aged 18-74, without diabetes, from the four U.S. field centers (Bronx, NY; Chicago, IL; Miami, FL; San Diego, CA) of the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) Sociocultural Ancillary study. Participants completed a measure of chronic life stress and a physical exam with oral glucose tolerance test. In a multivariate regression analysis with adjustment for demographic and health covariates, higher chronic stress was related to higher fasting glucose (standardized regression coefficient: =.09, p<.01), postload glucose (=.07, p<.05), and HbA1c levels (=.08, p<.01). However, there was no indirect effect of stress through inflammation. Findings suggest that higher chronic stress is associated with poorer glucose regulation in Hispanics, prior to the onset of a clinical diabetes diagnosis.
C1 [McCurley, Jessica L.] SDSU UCSD Joint Doctoral Program Clin Psychol, San Diego, CA USA.
   [Mills, Paul J.] Univ Calif San Diego, Dept Psychiat, San Diego, CA 92103 USA.
   [Roesch, Scott C.; Gallo, Linda C.] San Diego State Univ, Dept Psychol, San Diego, CA 92182 USA.
   [Carnethon, Mercedes] Northwestern Univ, Feinberg Sch Med, Dept Prevent Med, Chicago, IL 60611 USA.
   [Giacinto, Rebeca E.] SDSU UCSD Joint Doctoral Program Global Hlth, San Diego, CA USA.
   [Isasi, Carmen R.] Albert Einstein Coll Med, Dept Epidemiol & Populat Hlth, New York, NY USA.
   [Teng, Yanping; Sotres-Alvarez, Daniela] Univ N Carolina, Dept Biostat, Gillings Sch Global Publ Hlth, Collaborat Studies Coordinating Ctr, Chapel Hill, NC USA.
   [Llabre, Maria M.; Schneiderman, Neil] Univ Miami, Dept Psychol, Coral Gables, FL 33124 USA.
   [Penedo, Frank J.] Northwestern Univ, Feinberg Sch Med, Dept Med Social Sci, Chicago, IL 60611 USA.
C3 University of California System; University of California San Diego;
   California State University System; San Diego State University;
   Northwestern University; Feinberg School of Medicine; Yeshiva
   University; University of North Carolina; University of North Carolina
   Chapel Hill; University of Miami; Northwestern University; Feinberg
   School of Medicine
RP McCurley, JL (corresponding author), San Diego State Univ Univ Calif, 9245 Sky Pk Court,Suite 115, San Diego, CA 92123 USA.
EM jlmccurl@ucsd.edu
RI Sotres-Alvarez, Daniela/O-9085-2016
OI McCurley, Jessica/0000-0003-0356-5608; Gallo, Linda
   C./0000-0002-3678-5888; Carnethon, Mercedes/0000-0001-7035-0848
FU National Heart, Lung, and Blood Institute (NHLBI) [N01-HC65233,
   N01-HC65234, N01-HC65235, N01-HC65236, N01-HC65237]; National Center on
   Minority Health and Health Disparities; National Institute of Deafness
   and Other Communications Disorders; National Institute of Dental and
   Craniofacial Research; National Institute of Diabetes and Digestive and
   Kidney Diseases; National Institute of Neurological Disorders and
   Stroke; Office of Dietary Supplements; MIH/NHLBI [RC2HL101649]
FX The Hispanic Community Health Study/Study of Latinos is a collaborative
   investigation supported by contracts from the National Heart, Lung, and
   Blood Institute (NHLBI) to the University of North Carolina
   (N01-HC65233), University of Miami (N01-HC65234), Albert Einstein
   College of Medicine (N01-HC65235), Northwestern University
   (N01-HC65236), and San Diego State University (N01-HC65237). The
   following institutes/centers/offices also contributed to funding the
   HCHS/SOL through the NHLBI: National Center on Minority Health and
   Health Disparities, the National Institute of Deafness and Other
   Communications Disorders, the National Institute of Dental and
   Craniofacial Research, the National Institute of Diabetes and Digestive
   and Kidney Diseases, the National Institute of Neurological Disorders
   and Stroke, and the Office of Dietary Supplements. The HCHS/SOL
   Sociocultural Ancillary Study was supported by MIH/NHLBI grant number
   RC2HL101649 (PIs LCG and FJP). The authors thank the staff and
   participants of HCHS/SOL and the HCHS/SOL Sociocultural Ancillary Study
   for their important contributions. A complete list of staff and
   investigators is available on the study website at
   http://www.cscc.unc.edu/hchs
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NR 70
TC 33
Z9 48
U1 2
U2 19
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0048-5772
EI 1469-8986
J9 PSYCHOPHYSIOLOGY
JI Psychophysiology
PD AUG
PY 2015
VL 52
IS 8
BP 1071
EP 1079
DI 10.1111/psyp.12430
PG 9
WC Psychology, Biological; Neurosciences; Physiology; Psychology;
   Psychology, Experimental
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Neurosciences & Neurology; Physiology
GA CM8TC
UT WOS:000357973900011
PM 25898909
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Canneva, F
   Golub, Y
   Distler, J
   Dobner, J
   Meyer, S
   von Hörsten, S
AF Canneva, Fabio
   Golub, Yulia
   Distler, Joerg
   Dobner, Julia
   Meyer, Sandra
   von Hoersten, Stephan
TI DPP4-deficient congenic rats display blunted stress, improved fear
   extinction and increased central NPY
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE NPY; Anxiety; Stress; Fear; CD26; DPP4
ID DIPEPTIDYL-PEPTIDASE-IV; NEUROPEPTIDE-Y NPY; INDUCED OBESITY;
   IMMUNOREACTIVE-NEUROPEPTIDE; POTENTIATED STARTLE; CEREBROSPINAL-FLUID;
   METABOLIC SYNDROME; TRAUMA EXPOSURE; BASE-LINE; AREA CA1
AB Background: Inhibitors of dipeptidyl peptidase 4 (DPP4, CD26) are used for the treatment of type 2 diabetic patients and better glucose tolerance has been confirmed in functionally DPP4-deficient congenic rats (DPP4mut), along with immunological alterations and, interestingly, a stress-resilient phenotype. All these findings are in agreement with the "moonlighting" properties of DPP4, whose proteolytic action is responsible for the inactivation of a number of regulatory peptides including, but not limited to, neuropeptide Y (NPY).
   Among all candidate substrates, DPP4 displays highest affinity for NPY, an endogenous anxiolytic neurotransmitter that is suggested as a candidate biomarker in post-traumatic stress disorder (PTSD) and depression.
   Methods and results: Central and peripheral NPY levels were measured by ELISA in DPP4mut and DAwt rats revealing a significantly higher concentration of the peptide in the CSF of DPP4mut animals. This finding positively correlated with the blunted stress phenotype measured on an analgesia-meter. Additionally, when a classical fear- conditioning paradigm was investigated, short-term fear extinction was significantly potentiated in DPP4mut rats as compared to wt controls.
   Conclusions: Our findings indicate a positive correlation between reduced stress-responsiveness and increased central NPY, in DPP4mut rats. Most interestingly, the behavioral phenotype extends to facilitation of fear extinction. These observations raise further interest in DPP4-modulating drugs for the potential effect on NPY metabolism, as a therapeutic tool for psychiatric conditions such as anxiety disorders and PTSD. (C) 2015 Elsevier Ltd. All rights reserved.
C1 [Canneva, Fabio; Distler, Joerg; Dobner, Julia; Meyer, Sandra; von Hoersten, Stephan] Univ Klinikum Erlangen, Praklin Expt Tierzentrum, Dept Expt Therapy, D-91054 Erlangen, Germany.
   [Golub, Yulia] Univ Clin Erlangen, Dept Child & Adolescent Mental Hlth, D-91054 Erlangen, Germany.
C3 University of Erlangen Nuremberg; University of Erlangen Nuremberg
RP Canneva, F (corresponding author), Univ Klinikum Erlangen, Praklin Expt Tierzentrum PETZ, Dept Expt Therapy, Palmsanlage 5, D-91054 Erlangen, Germany.
EM Fabio.Canneva@uk-erlangen.de
RI Golub, Yulia/AHC-3528-2022; von Horsten, Stephan/G-9005-2015
OI Golub, Yulia/0000-0002-9191-5884; von Horsten,
   Stephan/0000-0001-6409-0664
FU ELAN Fund [ET-11.09.06.1]
FX The present work was partially supported by the ELAN Fund (ET-11.09.06.1
   to F.C.). The funding source had no rote in designing the study,
   collecting and analyzing the data.
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NR 72
TC 20
Z9 22
U1 0
U2 11
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD MAR
PY 2015
VL 53
BP 195
EP 206
DI 10.1016/j.psyneuen.2015.01.007
PG 12
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA CC6ZR
UT WOS:000350518000020
PM 25635612
DA 2025-06-11
ER

PT J
AU Gedikli, O
   Ozturk, M
   Turan, OE
   Ilter, A
   Hosoglu, Y
   Kiris, G
AF Gedikli, Omer
   Ozturk, Mustafa
   Turan, Oguzhan Ekrem
   Ilter, Abdusselam
   Hosoglu, Yusuf
   Kiris, Gulhanim
TI Epicardial adipose tissue thickness is increased in patients with
   cardiac syndrome X
SO INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
LA English
DT Article
DE Cardiac syndrome X; epicardial adipose tissue
ID NORMAL CORONARY-ARTERIES; LEFT-VENTRICULAR MASS; CHEST-PAIN; METABOLIC
   SYNDROME; FAT THICKNESS; RISK; ECHOCARDIOGRAPHY; ATHEROSCLEROSIS;
   INFLAMMATION; DYSFUNCTION
AB Background: Cardiac syndrome X (CSX) is defined as normal coronary arteries with angina pectoris and a positive stress test. Epicardial adipose tissue (EAT) plays an important role in inflammatory process in cardiovascular system, therefore EAT may affect the pathogenesis of different cardiovascular disease. The aim of this study was to investigate the EAT thickness in patients with CSX and compare normal subjects. Methods: We prospectively enrolled 30 consecutive patients with CSX. The control group consisted of 30 age and sex-matched individuals with anginal chest pain and a negative treadmill or myocardial perfusion scan test. EAT thickness was measured by transthoracic echocardiography. Results: There were no differences in baseline clinical, biochemical and echocardiographic characteristics between CSX patients and the control group. Patients with CSX had significantly increased EAT thickness than those of the controls (3.43 +/- 0.88 vs. 2.34 +/- 0.89 mm, p=0.0001). Conclusion: We found that EAT thickness is increased in patients with CSX. This finding suggests that EAT may contribute to the etiopathogenesis of the CSX.
C1 [Gedikli, Omer; Ilter, Abdusselam; Hosoglu, Yusuf] KTU, Fac Med, Dept Cardiol, TR-61080 Trabzon, Turkey.
   [Ozturk, Mustafa] Caycuma State Hosp, Dept Cardiol, Zonguldak, Turkey.
   [Turan, Oguzhan Ekrem] Aydin State Hosp, Dept Cardiol, Aydin, Turkey.
   [Kiris, Gulhanim] Ahi Evren Thorac & Cardiovasc Surg Training & Res, Dept Cardiol, Trabzon, Turkey.
C3 Karadeniz Technical University; Zonguldak Caycuma State Hospital; Aydin
   State Hospital; Trabzon Ahi Evren Thoracic & Cardiovascular Surgery
   Training & Research Hospital
RP Gedikli, O (corresponding author), KTU, Fac Med, Dept Cardiol, TR-61080 Trabzon, Turkey.
EM dromergedikli@gmail.com; mozturk81@yahoo.com
RI Hoşoğlu, Yusuf/AAY-3656-2020; öztürk, mustafa/ABF-3052-2021; TURAN,
   Oğuzhan Ekrem/AAQ-1672-2020; HOSOGLU, Yusuf/N-3187-2013
OI TURAN, Oguzhan Ekrem/0000-0003-3557-1682; HOSOGLU,
   Yusuf/0000-0003-2440-9209
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NR 26
TC 1
Z9 1
U1 0
U2 2
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 1940-5901
J9 INT J CLIN EXP MED
JI Int. J. Clin. Exp. Med.
PY 2014
VL 7
IS 1
BP 194
EP 198
PG 5
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA AD3MW
UT WOS:000333151200024
PM 24482707
DA 2025-06-11
ER

PT J
AU Hwang, WJ
   Lee, CY
AF Hwang, Won Ju
   Lee, Chung Yul
TI Effect of psychosocial factors on metabolic syndrome in male and female
   blue-collar workers
SO JAPAN JOURNAL OF NURSING SCIENCE
LA English
DT Article
DE metabolic syndrome; occupational health; psychosocial factors
ID CORONARY-HEART-DISEASE; EFFORT-REWARD IMBALANCE; CARDIOVASCULAR
   RISK-FACTORS; JOB STRESS MODELS; BLOOD-PRESSURE; MYOCARDIAL-INFARCTION;
   PSYCHOMETRIC PROPERTIES; SOCIAL SUPPORT; KOREAN VERSION; STRAIN
AB Aim: The purposes of this study were to examine the relationship between psychosocial factors and metabolic syndrome among male and female blue-collar workers, and which factors influence their metabolic syndrome by sex. Methods: A cross-sectional study was completed of 154 men and 80 women working at small companies in Korea. The data were collected through a structured questionnaire, blood test, and anthropometric and blood pressure measure. Metabolic syndrome was diagnosed from the results of blood test and the measurements of waist circumference and blood pressure. Results: The prevalence of metabolic syndrome among male and female blue-collar workers was 24.0% and 7.5%, respectively. Multiple logistic regression analysis was performed to examine factors of metabolic syndrome associated with sex. After controlling for age, marital status, smoking, alcohol drinking, shift work, overtime work, and physical exercise, job stress (odds ratio [OR]=3.10, P=0.005) and risk perception (OR=1.12, P=0.016) were influencing factors for men, and low job stress (OR=0.05, P=0.04), low social support (OR=1.51, P=0.009), and risk perception (OR=1.27, P=0.023) for women. Conclusion: Metabolic syndrome among blue-collar workers is closely related to psychosocial factors, such as job stress, social support, and risk perception, with the effect of job stress a point of difference between men and women. Occupational health nurses should be cognizant of the importance of assessing the effect of psychosocial factors on cardiovascular risk for blue-collar workers.
C1 [Hwang, Won Ju] Kyung Hee Univ, East West Nursing Res Inst, Coll Nursing Sci, Seoul 130701, South Korea.
   [Lee, Chung Yul] Yonsei Univ, Nursing Policy Res Inst, Coll Nursing, Seoul 120749, South Korea.
C3 Kyung Hee University; Yonsei University; Yonsei University Health System
RP Hwang, WJ (corresponding author), Kyung Hee Univ, East West Nursing Res Inst, Coll Nursing Sci, 26 Kyunghee Daero, Seoul 130701, South Korea.
EM hwangwj@khu.ac.kr
OI Hwang, Won Ju/0000-0002-0498-6183
FU Pacific Rim Research Program Advanced Graduate Fellowship Program;
   University of California; Sigma Theta Tau National Honor Society of
   Nursing Small Grant, USA
FX This study was supported by the Pacific Rim Research Program Advanced
   Graduate Fellowship Program, University of California and the Sigma
   Theta Tau National Honor Society of Nursing Small Grant, USA. We would
   like to acknowledge Dr Steven Paul for his statistical consultation. We
   also would like to thank study participants and OHC staff for their
   assistance with the data collection.
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NR 52
TC 27
Z9 33
U1 0
U2 23
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-7932
EI 1742-7924
J9 JPN J NURS SCI
JI Jpn. J. Nurs. Sci.
PD JAN
PY 2014
VL 11
IS 1
BP 23
EP 34
DI 10.1111/j.1742-7924.2012.00226.x
PG 12
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA AA5XN
UT WOS:000331173000004
PM 24460599
DA 2025-06-11
ER

PT J
AU Miller, NE
   Steptoe, A
AF Miller, Natalie Ella
   Steptoe, Andrew
TI Pericardial Fat, Socioeconomic Status, and Biological Responses to Acute
   Mental Stress
SO PSYCHOSOMATIC MEDICINE
LA English
DT Article
DE pericardial fat; socioeconomic status; cardiovascular disease; stress
   reactivity; stress recovery; BMI = body mass index; CES-D = Centre for
   Epidemiological Studies Depression Scale; CHD = coronary heart disease;
   CI = confidence interval; CV = coefficient of variation; CVD =
   cardiovascular disease; IL-6=interleukin 6; SE = standard error; SES =
   socioeconomic status; TNF-alpha = tumor necrosis factor alpha
ID ACUTE PSYCHOLOGICAL STRESS; EPICARDIAL ADIPOSE-TISSUE;
   CORONARY-HEART-DISEASE; VISCERAL ABDOMINAL FAT; CARDIOVASCULAR-DISEASE;
   RATE-VARIABILITY; RISK-FACTORS; ARTERY CALCIFICATION; CORTISOL
   REACTIVITY; METABOLIC SYNDROME
AB ObjectiveCentral adiposity is associated with impaired biological responses to mental stress, and socioeconomic status (SES) might moderate this relationship. However, evidence for associations between pericardial fat, a fat depot implicated in the pathogenesis of cardiovascular disease (CVD), with cardiovascular and inflammatory responses to mental stress is lacking, and moderation by SES is unknown.MethodsThe sample was 473 healthy men and women (mean age = 62.8 years) from the Whitehall II study. Cardiovascular and inflammatory responses to laboratory-induced mental stress, consisting of a 5-minute Stroop task and 5-minute mirror tracing task, were assessed. Pericardial fat volume was measured using electron bean computed tomography and adjusted for body surface area. SES was defined by grade of employment within the British civil service (higher/intermediate/lower).ResultsPericardial fat was associated with lower heart rate variability, raised heart rate, plasma interleukin-6, fibrinogen, and C-reactive protein at baseline. Furthermore, greater pericardial fat was associated with lower systolic blood pressure reactivity to mental stress, independent of sociodemographics, smoking status, waist-to-hip ratio, and baseline systolic blood pressure. There were no interactions between pericardial fat and SES for any outcome.ConclusionsGreater pericardial fat was associated with numerous cardiovascular and inflammatory factors implicated in CVD. It was also related to reduced systolic blood pressure reactivity to acute mental stress, independent of central adiposity and baseline systolic blood pressure. This association did not vary by SES. Reduced systolic blood pressure reactivity to mental stress might contribute to the association between greater pericardial fat and CVD.
C1 [Miller, Natalie Ella; Steptoe, Andrew] UCL, Inst Epidemiol & Hlth Care, Dept Behav Sci & Hlth, 1-19 Torrington Pl,Gower St, London, England.
C3 University of London; University College London
RP Miller, NE (corresponding author), UCL, Inst Epidemiol & Hlth Care, Dept Behav Sci & Hlth, 1-19 Torrington Pl,Gower St, London, England.
EM Natalie.miller.20@ucl.ac.uk; a.steptoe@ucl.ac.uk
RI Steptoe, Andrew/Y-2440-2019
OI Miller, Natalie/0000-0002-5067-0649
FU British Heart Foundation [RG/10/005/28296]; ESRC-BBSRC Soc-B Centre for
   Doctoral Training [ES/P000347/1]; MRC [MR/R024227/1] Funding Source:
   UKRI
FX This study was supported by the British Heart Foundation
   (RG/10/005/28296). N.M. is funded by the ESRC-BBSRC Soc-B Centre for
   Doctoral Training (ES/P000347/1). The authors declare no conflicts of
   interest.
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NR 79
TC 0
Z9 0
U1 0
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0033-3174
EI 1534-7796
J9 PSYCHOSOM MED
JI Psychosom. Med.
PD APR
PY 2023
VL 85
IS 3
BP 280
EP 288
DI 10.1097/PSY.0000000000001169
PG 9
WC Psychiatry; Psychology; Psychology, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry; Psychology
GA C5TP0
UT WOS:000962540000010
PM 36705572
OA Green Submitted, Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Sohl, SJ
   Wallston, KA
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   Birdee, GS
AF Sohl, Stephanie J.
   Wallston, Kenneth A.
   Watkins, Keiana
   Birdee, Gurjeet S.
TI Yoga for Risk Reduction of Metabolic Syndrome: Patient-Reported Outcomes
   from a Randomized Controlled Pilot Study
SO EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Article
ID DIABETES PREVENTION PROGRAM; LIFE-STYLE INTERVENTION; QUALITY-OF-LIFE;
   CARDIOVASCULAR-DISEASE; RESTORATIVE YOGA; METAANALYSIS; INDIVIDUALS;
   COMMUNITY; SF-36; MODEL
AB Lifestyle change is recommended as treatment for adults at risk for metabolic syndrome (MetS), although adoption of new behavioral patterns is limited. In addition, most existing lifestyle interventions do not address psychological stress or quality of life, both of which impact the burden of MetS. Yoga, a form of physical activity that incorporates psychological components (e.g., maintaining attention, relaxation), is a promising intervention for improving the burden of MetS. This randomized controlled trial assessed the feasibility and preliminary efficacy of a 12-week yoga program coupled with an evidence-based health education program (HED) compared to HED alone. A secondary, exploratory aim examined perceived stress, quality of life, and related psychological outcomes (mindfulness, perceived health competence, and mood). Sixty-seven adults at risk for MetS enrolled (mean age [SD]: 58 [10] years; 50% male; 79% non-Hispanic White). Preliminary results revealed significantly larger improvements in two quality of life domains (role-physical and general health perceptions) in the HED plus yoga group versus HED alone (ps < 0.05). This is the first study that implemented lifestyle education along with yoga to evaluate the potential unique effects of yoga on participants at risk for MetS. A larger clinical trial is warranted to further investigate these promising patient-reported outcomes.
C1 [Sohl, Stephanie J.; Watkins, Keiana; Birdee, Gurjeet S.] Vanderbilt Univ, Sch Med, Nashville, TN 37212 USA.
   [Sohl, Stephanie J.] Wake Forest Sch Med, Winston Salem, NC USA.
   [Wallston, Kenneth A.] Vanderbilt Univ, Sch Nursing, Nashville, TN 37240 USA.
C3 Vanderbilt University; Wake Forest University; Vanderbilt University
RP Birdee, GS (corresponding author), Vanderbilt Univ, Sch Med, Nashville, TN 37212 USA.
EM gurjeet.birdee@vanderbilt.edu
RI Birdee, Gurjeet/I-7888-2015; Stefanadis, Christodoulos/ABH-2232-2020
OI Sohl, Stephanie/0000-0002-4717-0328; Stefanadis,
   Christodoulos/0000-0001-5974-6454
FU Vanderbilt Center for Diabetes Translational Research Pilot Award
   [P30-DK092986]; National Center for Complementary & Integrative Health
   of the National Institutes of Health [K01AT008219, K23 AT006965]; CTSA
   Award from the National Center for Advancing Translational Sciences
   [UL1TR000445]
FX This study was funded by Vanderbilt Center for Diabetes Translational
   Research Pilot Award P30-DK092986. Drs. Stephanie Sohl and Gurjeet
   Birdee are supported by the National Center for Complementary &
   Integrative Health of the National Institutes of Health under Awards
   nos. K01AT008219 and K23 AT006965, respectively. This study also
   received support through the CTSA Award no. UL1TR000445 from the
   National Center for Advancing Translational Sciences.
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NR 32
TC 5
Z9 5
U1 1
U2 2
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1741-427X
EI 1741-4288
J9 EVID-BASED COMPL ALT
JI Evid.-based Complement Altern. Med.
PY 2016
VL 2016
AR 3094589
DI 10.1155/2016/3094589
PG 9
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA EB4XB
UT WOS:000387376000001
PM 27847524
OA Green Submitted, Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Bjerregaard, AA
   Petersen, MW
   Gormsen, LK
   Skovbjerg, S
   Jorgensen, NR
   Linneberg, A
   Cedeno-Laurent, JG
   Jorgensen, T
   Dantoft, TM
AF Bjerregaard, Anne A.
   Petersen, Marie W.
   Gormsen, Lise Kirstine
   Skovbjerg, Sine
   Jorgensen, Niklas R.
   Linneberg, Allan
   Cedeno-Laurent, Jose G.
   Jorgensen, Torben
   Dantoft, Thomas M.
TI Insulin Resistance Is Associated with Multiple Chemical Sensitivity in a
   Danish Population-Based Study-DanFunD
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Article
DE multiple chemical sensitivity; MSC; DanFunD; functional somatic
   disorders
ID PSYCHOLOGICAL STRESS; METABOLIC SYNDROME; PREVALENCE; FIBROMYALGIA;
   BIOMARKERS; SYMPTOMS; IMPACT; MCS
AB Multiple chemical sensitivity (MCS) is a multisystem syndrome, and limited knowledge of its pathophysiology exists. Based on the population-based Danish cohort DanFunD, this study investigated metabolic health in people with MCS compared to individuals who did not have MCS. From 9656 cohort participants aged 18-76 years old, 1.95% were categorized as MCS individuals with comorbid functional somatic disorders (MCS + FSD, n = 188), and 1.13% were categorized as MCS without functional somatic disorders (MCS divided by FSD, n = 109). MCS was characterized based on three criteria: the experience of symptoms upon exposure to common odors and airborne chemicals, symptoms related the central nervous systems and others organ symptoms, and significant impact on every day, social, and occupational life. The remaining study population without MCS or any other functional somatic disorders were regarded as controls. We used adjusted multiple linear regression with link-function to evaluate the associations between lipid and glucose metabolism markers and MCS. We also tested the odds ratio of metabolic syndrome in MCS. Results did not point to statistically significant associations between lipid biomarkers or metabolic syndrome and both MCS groups compared to the controls. We found that MCS individuals may be more insulin resistant and that MCS divided by FSD may have an impaired glucose metabolism when compared to controls.
C1 [Bjerregaard, Anne A.; Linneberg, Allan; Jorgensen, Torben; Dantoft, Thomas M.] Bispebjerg & Frederiksberg Hosp, Ctr Clin Res & Prevent, Nordre Fasanvej 57,Entrance 5, DK-2000 Frederiksberg, Denmark.
   [Bjerregaard, Anne A.] Statens Serum Inst, Dept Epidemiol Res, Artillerivej 3, DK-2300 Copenhagen, Denmark.
   [Petersen, Marie W.; Gormsen, Lise Kirstine] Aarhus Univ Hosp, Res Clin Funct Disorders & Psychosomat, Univ Byen 22-23, DK-8000 Aarhus C, Denmark.
   [Skovbjerg, Sine] Aarhus Univ, Dept Clin Med, Danish Ctr Mindfulness, DK-8000 Aarhus C, Denmark.
   [Jorgensen, Niklas R.] Rigshosp, Dept Clin Biochem, Valdemar Hansens Vej 13, DK-2600 Glostrup, Denmark.
   [Jorgensen, Niklas R.] Univ Copenhagen, Inst Clin Med, Blegdamsvej 3, DK-2200 Copenhagen, Denmark.
   [Linneberg, Allan] Univ Copenhagen, Fac Hlth & Med Sci, Dept Clin Med, Blegdamsvej 3B, DK-2200 Copenhagen, Denmark.
   [Cedeno-Laurent, Jose G.] Harvard TH Chan Sch Publ Hlth, Dept Exposure Epidemiol & Risk Program, 1350 Massachusetts Ave, Cambridge, MA 02138 USA.
   [Jorgensen, Torben] Univ Copenhagen, Fac Hlth & Med Sci, Dept Publ Hlth, Blegdamsvej 3B, DK-2200 Copenhagen, Denmark.
C3 University of Copenhagen; Bispebjerg Hospital; Statens Serum Institut;
   Aarhus University; Aarhus University; Rigshospitalet; University of
   Copenhagen; University of Copenhagen; Harvard University; Harvard T.H.
   Chan School of Public Health; University of Copenhagen
RP Bjerregaard, AA (corresponding author), Bispebjerg & Frederiksberg Hosp, Ctr Clin Res & Prevent, Nordre Fasanvej 57,Entrance 5, DK-2000 Frederiksberg, Denmark.; Bjerregaard, AA (corresponding author), Statens Serum Inst, Dept Epidemiol Res, Artillerivej 3, DK-2300 Copenhagen, Denmark.
EM anne.ahrendt.bjerregaard@regionh.dk; mawept@rm.dk; lisgor@rm.dk;
   sine.skovbjerg@clin.au.dk; niklas.rye.joergensen@regionh.dk;
   allan.linneberg@regionh.dk; jcedenol@hsph.harvard.edu;
   Torben.joergensen@regionh.dk; Thomas.meinertz.dantoft@regionh.dk
RI Jørgensen, Niklas/B-6003-2012; Jørgensen, Torben/Z-1335-2018; Gormsen,
   lise/AAE-1957-2019; Bjerregaard, Anne/H-6205-2019; Petersen,
   Marie/AAE-6139-2019; Dantoft, Thomas Meinertz/N-2702-2017
OI Skovbjerg, Sine/0000-0003-0616-3137; Dantoft, Thomas
   Meinertz/0000-0001-7437-7052; Ahrendt Bjerregaard,
   Anne/0000-0002-0628-5292; Cedeno Laurent, Jose
   Guillermo/0000-0001-7098-0954; Linneberg, Allan/0000-0002-0994-0184;
   Gormsen, Lise/0000-0002-5716-0211
FU Marilyn Hoffmann Foundation [2021-1]; Trygfonden [7-11-0213]; Lundbeck
   Foundation [R155-2013-14070]; Harvard Hoffman Program on Chemicals and
   Health
FX This research was funded by the Marilyn Hoffmann Foundation (grant
   #2021-1), the Trygfonden (7-11-0213), and the Lundbeck Foundation
   (R155-2013-14070). Cedeno-Laurent was funded by the Harvard Hoffman
   Program on Chemicals and Health.
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NR 53
TC 7
Z9 7
U1 0
U2 4
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD DEC
PY 2021
VL 18
IS 23
AR 12654
DI 10.3390/ijerph182312654
PG 13
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA XW1JQ
UT WOS:000735384900001
PM 34886380
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Yen, YC
   Huang, CK
   Tai, CM
AF Yen, Yung-Chieh
   Huang, Chih-Kuan
   Tai, Chi-Ming
TI Psychiatric aspects of bariatric surgery
SO CURRENT OPINION IN PSYCHIATRY
LA English
DT Review
DE bariatric surgery; bioenterics intragastric balloon; cognition;
   psychiatric disorder; suicide
ID CHILDHOOD PARENTAL LOSS; BINGE-EATING DISORDER; WEIGHT-LOSS OUTCOMES;
   COGNITIVE FUNCTION; INTRAGASTRIC BALLOON; CONTROLLED-TRIAL; GASTRIC
   BYPASS; FOOD ADDICTION; SEVERE OBESITY; MENTAL-HEALTH
AB Purpose of review
   Bariatric surgery has been consistently shown to be effective in long-term marked weight loss and in bringing significant improvement to medical comorbidities such as metabolic syndrome. Empirical data suggest a high prevalence of psychiatric disorders among bariatric surgery candidates. In this review, we focus on the studies published recently with a high impact on our understanding of the role of psychiatry in bariatric surgery.
   Recent findings
   This article reviews the specific psychopathologies before surgery, changes in psychopathologies after surgery, suicide risk related to bariatric surgery, factors associated with weight loss, and recommendations for presurgical and postsurgical assessment and management. Research indicates a decrease in certain psychiatric symptoms after weight loss with bariatric surgery. However, the risk of suicide and unsuccessful weight loss in some bariatric surgery patients make monitoring following surgery as important as careful assessment and management before surgery. Specific considerations for youth and older populations and future potential research foci are discussed.
   Summary
   Recent publications suggest new directions for psychiatric evaluation and interventions for bariatric surgery patients. Future research on outcomes of specific populations, effectiveness of psychopharmacotherapy, and underlying pathophysiology are warranted for the advancement of treating bariatric surgery patients.
C1 [Yen, Yung-Chieh] E Da Hosp, Dept Psychiat, Kaohsiung 824, Taiwan.
   [Yen, Yung-Chieh] I Shou Univ, Sch Med, Kaohsiung, Taiwan.
   [Huang, Chih-Kuan; Tai, Chi-Ming] E Da Hosp, Bariatr & Metab Int BMI Surg Ctr, Kaohsiung 824, Taiwan.
   [Huang, Chih-Kuan] I Shou Univ, E Da Hosp, Dept Surg, Kaohsiung, Taiwan.
   [Tai, Chi-Ming] I Shou Univ, E Da Hosp, Dept Internal Med, Kaohsiung, Taiwan.
C3 E-Da Hospital; I Shou University; E-Da Hospital; I Shou University; E-Da
   Hospital; E-Da Hospital; I Shou University
RP Yen, YC (corresponding author), E Da Hosp, Dept Psychiat, 1 Yi Da Rd, Kaohsiung 824, Taiwan.
EM jackycyen@yahoo.com
RI Liu, Chen-Hua/F-6608-2018
FU E-Da Hospital, Taiwan [EDAHI100002, EDAHP100015, EDAHI102004,
   EDAHI103004]
FX The authors gratefully acknowledge the grant support of the E-Da
   Hospital, Taiwan (EDAHI100002, EDAHP100015, EDAHI102004, and
   EDAHI103004).
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   Salamone JD, 2013, CELL METAB, V17, P469, DOI 10.1016/j.cmet.2013.03.011
   Semanscin-Doerr DA, 2010, SURG OBES RELAT DIS, V6, P191, DOI 10.1016/j.soard.2009.11.017
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   Spitznagel MB, 2013, SURG OBES RELAT DIS, V9, P453, DOI 10.1016/j.soard.2011.10.008
   Stanek KM, 2013, PROG NEURO-PSYCHOPH, V47, P135, DOI 10.1016/j.pnpbp.2012.06.021
   Sysko R, 2013, CLIN OBES, V3, P62, DOI 10.1111/cob.12019
   Sysko R, 2012, J CLIN PSYCHIAT, V73, P1351, DOI 10.4088/JCP.12m07690
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   Windover AK, 2010, SURG OBES RELAT DIS, V6, P702, DOI 10.1016/j.soard.2010.08.014
NR 62
TC 56
Z9 63
U1 0
U2 42
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0951-7367
EI 1473-6578
J9 CURR OPIN PSYCHIATR
JI Curr. Opin. Psychiatr.
PD SEP
PY 2014
VL 27
IS 5
BP 374
EP 379
DI 10.1097/YCO.0000000000000085
PG 6
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA AN1UN
UT WOS:000340369300011
PM 25036421
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Koyama, F
   Yoda, T
   Hirao, T
AF Koyama, Fumihiko
   Yoda, Takeshi
   Hirao, Tomohiro
TI Insomnia and depression: Japanese hospital workers questionnaire survey
SO OPEN MEDICINE
LA English
DT Article
DE Insomnia; depression; Fatigue; Lifestyle-related diseases; Chronic pain;
   Early detection
ID SLEEP; DISORDERS; PAIN; ASSOCIATION; STRESS; FEAR
AB Objectives: This study aimed to identify a correlation between insomnia and the occurrence of depression among Japanese hospital employees using the data obtained from a self-reported questionnaire.
   Methods: A self-administered questionnaire on sleeping patterns, depression, fatigue, lifestyle-related diseases, and chronic pain was given to 7690 employees aged 20-60 years, and 5,083 employees responded.
   Results: An insomnia score of >2 was observed in 840 (13%) respondents. Chronic insomnia correlated significantly with gender, occupation, overtime work, metabolic syndrome, chronic pain, fatigue, and depression. Moreover, significant negative effects on depression scores were observed in males aged 30-39 (partial regression coefficient: b=0.357, p=0.016), females aged 20-29 (b=0.494, p<0.001), male administrative staff (b=0.475, p=0.003), males with metabolic syndrome (b=0.258, p=0.023), and both genders with chronic insomnia (male; b=0.480, p<0.001: female; b=0.485, p<0.001), and fatigue (male; b=1.180, p<0.001: female; b=1.151, p<0.001).
   Discussion: Insomnia is a risk factor for depression and for other lifestyle-related diseases. The insomnia score may be useful in preventative care settings because it is associated with a wide spectrum of diseases and serves as a valuable marker for early detection of depression. Thus, our future studies will focus on establishing a method for early detection of depression symptoms among workers across various job profiles.
C1 [Yoda, Takeshi; Hirao, Tomohiro] Kagawa Univ, Dept Publ Hlth, Fac Med, 1750-1 Ikenobe, Miki, Kagawa 7610793, Japan.
   [Koyama, Fumihiko] Toho Univ, Sakura Med Ctr, Dept Occupat Mental Hlth Return Work Support Serv, Tokyo, Japan.
C3 Kagawa University; Toho University
RP Yoda, T (corresponding author), Kagawa Univ, Dept Publ Hlth, Fac Med, 1750-1 Ikenobe, Miki, Kagawa 7610793, Japan.
EM tyoda@med.kagawa-u.ac.jp
RI Yoda, Takeshi/AAW-5384-2021
OI Yoda, Takeshi/0000-0001-6950-5056
CR [Anonymous], JPN J OCCUP MED TRAU
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NR 33
TC 7
Z9 8
U1 0
U2 2
PU DE GRUYTER OPEN LTD
PI BIHR
PA FAC CONSTRUCTION, CADASTRE & ARCHITECTURE, UNIV PUB HSE ORADEA, 1
   UNIVERSITATII ST, 410087 BIHR, ROMANIA
SN 2391-5463
J9 OPEN MED-WARSAW
JI Open Med.
PY 2017
VL 12
IS 1
BP 391
EP 398
DI 10.1515/med-2017-0056
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA FV3TO
UT WOS:000424492400001
PM 29318183
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Zhou, SS
   Zhou, YM
   Li, D
   Lun, YZ
AF Zhou, Shi-Sheng
   Zhou, Yi-Ming
   Li, Da
   Lun, Yong-Zhi
TI Dietary methyl-consuming compounds and metabolic syndrome
SO HYPERTENSION RESEARCH
LA English
DT Review
DE cardiovascular disease; diet; metabolic syndrome; methyl-consuming
   compounds; niacin
ID PLASMA HOMOCYSTEINE LEVELS; OXIDATIVE STRESS; B-VITAMINS; FOLIC-ACID;
   ESSENTIAL-HYPERTENSION; INSULIN-RESISTANCE; HUMAN-POPULATIONS;
   UNITED-STATES; US ADULTS; NIACIN
AB The metabolic syndrome, a major risk factor for type 2 diabetes and cardiovascular disease, is a cluster of metabolic abnormalities including obesity, insulin resistance, hypertension and dyslipidemia. Although systemic oxidative stress and aberrant methylation status are known to have important roles in the development of metabolic syndrome, how they occur remains unclear. The metabolism of methyl-consuming compounds generates reactive oxygen species and consumes labile methyl groups; therefore, a chronic increase in the levels of methyl-consuming compounds in the body can induce not only oxidative stress and subsequent tissue injury, but also methyl-group pool depletion and subsequent aberrant methylation status. In the past few decades, the intake amount of methyl-consuming compounds has substantially increased primarily due to pollution, food additives, niacin fortification and high meat consumption. Thus, increased methyl consumers might have a causal role in the development and prevalence of metabolic syndrome and its related diseases. Moreover, factors that decrease the elimination/metabolism of methyl-consuming compounds and other xenobiotics (for example, sweat gland inactivity and decreased liver function) or increase the generation of endogenous methyl-consuming compounds (for example, mental stress-induced increase in catecholamine release) may accelerate the progression of metabolic syndrome. Based on current nutrition knowledge and the available evidence from epidemiological, ecological, clinical and laboratory studies on metabolic syndrome and its related diseases, this review outlines the relationship between methyl supply-consumption imbalance and metabolic syndrome, and proposes a novel mechanism for the pathogenesis and prevalence of metabolic syndrome and its related diseases. Hypertension Research (2011) 34, 1239-1245; doi:10.1038/hr.2011.133; published online 4 August 2011
C1 [Zhou, Shi-Sheng; Li, Da] Dalian Univ, Dept Physiol, Coll Med, Dalian 116622, Peoples R China.
   [Zhou, Shi-Sheng; Lun, Yong-Zhi] Dalian Univ, Inst Basic Med Sci, Coll Med, Dalian 116622, Peoples R China.
   [Zhou, Yi-Ming] Natl Inst Nat Sci, Natl Inst Physiol Sci, Sect Cell Signaling, Okazaki Inst Integrat Biosci, Okazaki, Aichi 4448585, Japan.
C3 Dalian University; Dalian University; National Institutes of Natural
   Sciences (NINS) - Japan; Okazaki Institute for Integrative Bioscience
   (OIIB); National Institute for Physiological Sciences (NIPS)
RP Zhou, SS (corresponding author), Dalian Univ, Dept Physiol, Coll Med, 10 Xuefu Rd, Dalian 116622, Peoples R China.
EM zhouss@ymail.com
RI Zhou, Yiming/AAK-3059-2021; LUN, Yong-Zhi/G-2608-2014
OI LUN, Yong-Zhi/0000-0002-7947-9274; Zhou, Shi-Sheng/0000-0001-5156-3610
FU National Natural Science Foundation of China [30570665]; Foundation of
   Key Laboratory of Education Department of Liaoning Province [2009S005];
   Foundation of Dalian Technology Bureau [2008E13SF182]
FX This work was supported by National Natural Science Foundation of China
   (No. 30570665), the Foundation of Key Laboratory of Education Department
   of Liaoning Province (No. 2009S005) and the Foundation of Dalian
   Technology Bureau (No. 2008E13SF182).
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NR 88
TC 31
Z9 36
U1 0
U2 17
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0916-9636
EI 1348-4214
J9 HYPERTENS RES
JI Hypertens. Res.
PD DEC
PY 2011
VL 34
IS 12
BP 1239
EP 1245
DI 10.1038/hr.2011.133
PG 7
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 863PL
UT WOS:000298177800001
PM 21814217
OA Bronze
DA 2025-06-11
ER

PT J
AU Kirilly, E
   Gonda, X
   Bagdy, G
AF Kirilly, E.
   Gonda, X.
   Bagdy, G.
TI CB1 receptor antagonists: new discoveries leading to new perspectives
SO ACTA PHYSIOLOGICA
LA English
DT Review
DE anxiety; CNR1; depression; personalized medicine; serotonin transporter;
   5-HTTLPR
ID SEROTONIN TRANSPORTER GENE; HYPOTHALAMIC PARAVENTRICULAR NUCLEUS;
   CARDIOMETABOLIC RISK-FACTORS; ANTIDEPRESSANT-INDUCED MANIA; CANNABINOID
   RECEPTOR; ENDOCANNABINOID SYSTEM; WEIGHT-LOSS; FUNCTIONAL POLYMORPHISM;
   PROMOTER POLYMORPHISM; 5-HTTLPR POLYMORPHISM
AB CB1 receptor antagonists were among the most promising drug targets in the last decade. They have been explored and found to be effective as therapeutic agents for obesity and related cardiometabolic problems; however, use of rimonabant, the first marketed CB1 receptor antagonist, has been suspended because of its anxiogenic and depressogenic side effects. Because some other antiobesity drugs, like dexfenfluramine or sibutramine, were also suspended, the unmet need for drugs that reduce body weight became enormous. One approach that emerged was the use of CB1 receptor antagonists that poorly cross the blood brain barrier, the second, the development of neutral antagonists instead of inverse agonists, and the third, use of personalized medicine, namely the selection of the patient population without psychiatric side effects. In this review, we dissect the peripheral and central mechanisms involved in the effects of CB1 receptor antagonists and argue that central mechanisms are more or less involved in most cardiometabolic therapeutic effects and thus, among patients with unsatisfactory therapeutic response to compounds with peripheral action, centrally acting antagonists may be needed. An analysis of pharmacogenetic factors may help to identify persons who are at no or low risk for psychiatric adverse effects. Here, we present the models and identify molecular mechanisms and receptors involved in the effects of stress-, anxiety- and depression-related neurocircuitries sensitive to CB1 receptor antagonists, like the serotonergic, noradrenergic and dopaminergic systems, which are not only regulated by CB1 receptors, but also regulate the synthesis of the endocannabinoid 2-arachidonoyl-glycerol.
C1 [Kirilly, E.; Bagdy, G.] Semmelweis Univ, Dept Pharmacodynam, H-1089 Budapest, Hungary.
   [Gonda, X.] Semmelweis Univ, Dept Clin & Theoret Mental Hlth, Kutvolgyi Clin Ctr, H-1089 Budapest, Hungary.
   [Bagdy, G.] Hungarian Acad Sci, Budapest, Hungary.
   [Bagdy, G.] Semmelweis Univ, Grp Neurochem, H-1089 Budapest, Hungary.
   [Bagdy, G.] Semmelweis Univ, Grp Neuropsychopharmacol, H-1089 Budapest, Hungary.
C3 Semmelweis University; Semmelweis University; Hungarian Academy of
   Sciences; Semmelweis University; Semmelweis University
RP Bagdy, G (corresponding author), Semmelweis Univ, Dept Pharmacodynam, Nagyvarad Ter 4, H-1089 Budapest, Hungary.
EM bag13638@iif.hu
RI Bagdy, Gyorgy/O-3893-2017; Gonda, Xenia/B-2713-2008
OI Bagdy, Gyorgy/0000-0001-8141-3410; Gonda, Xenia/0000-0001-9015-4203
FU EU [LSHM-CT-2004-503474, TAMOP-4.2.1.B-09/1/KMR-2010-0001, ETT
   318/041/2009]
FX The preparation of this review was supported by the Sixth Framework
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TC 62
Z9 70
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U2 26
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1748-1708
EI 1748-1716
J9 ACTA PHYSIOL
JI Acta Physiol.
PD MAY
PY 2012
VL 205
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BP 41
EP 60
DI 10.1111/j.1748-1716.2012.02402.x
PG 20
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
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GA 917EC
UT WOS:000302154300006
PM 22463610
DA 2025-06-11
ER

PT J
AU Kemp, DE
   Ismail-Beigi, F
   Ganocy, SJ
   Conroy, C
   Gao, KM
   Obral, S
   Fein, E
   Findling, RL
   Calabrese, JR
AF Kemp, David E.
   Ismail-Beigi, Faramarz
   Ganocy, Stephen J.
   Conroy, Carla
   Gao, Keming
   Obral, Sarah
   Fein, Elizabeth
   Findling, Robert L.
   Calabrese, Joseph R.
TI Use of insulin sensitizers for the treatment of major depressive
   disorder: A pilot study of pioglitazone for major depression accompanied
   by abdominal obesity
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Major depressive disorder; Pioglitazone; Metabolic syndrome; Insulin
   resistance
ID PPAR-GAMMA AGONIST; MOOD DISORDERS; DOUBLE-BLIND; OLDER MEN; SYMPTOMS;
   ROSIGLITAZONE; SENSITIVITY; RESISTANCE; SAFETY; INTERVIEW
AB Objective: This study was conducted to examine the safety and efficacy of pioglitazone, a thiazolidinedione insulin sensitizer, in adult outpatients with major depressive disorder.
   Method: In a 12-week, open-label, flexible-dose study, 23 patients with major depressive disorder received pioglitazone monotherapy or adjunctive therapy initiated at 15 mg daily. Subjects were required to meet criteria for abdominal obesity (waist circumference >35 in. in women and >40 in. in men) or metabolic syndrome. The primary efficacy measure was the change from baseline to Week 12 on the Inventory of Depressive Symptomatology (IDS) total score. Partial responders (>= 25% decrease in IDS total score) were eligible to participate in an optional extension phase for an additional three months.
   Results: Pioglitazone decreased depression symptom severity from a total IDS score of 40.3 +/- 1.8 to 19.2 +/- 1.8 at Week 12 (p<.001). Among partial responders (>= 25% decrease in IDS total score), an improvement in depressive symptoms was maintained during an additional 3-month extension phase (total duration = 24 weeks) according to IDS total scores (p<.001). Patients experienced a reduction in insulin resistance from baseline to Week 12 according to the log homeostasis model assessment (- 0.8 +/- 0.75; p<.001) and a significant reduction in inflammation as measured by log highly- sensitive C-reactive protein (- 0.87 +/- 0.72; p<.001). During the current episode, the majority of participants (74%, n = 17), had already failed at least one antidepressant trial. The most common side effects were headache and dizziness; no patient discontinued due to side effects.
   Limitations: These data are limited by a small sample size and an open-label study design with no placebo control.
   Conclusion: Although preliminary, pioglitazone appears to reduce depression severity and improve several markers of cardiometabolic risk, including insulin resistance and inflammation. larger. placebo-controlled studies are indicated. (C) 2011 Elsevier B.V. All rights reserved.
C1 [Kemp, David E.; Ganocy, Stephen J.; Conroy, Carla; Gao, Keming; Obral, Sarah; Fein, Elizabeth; Findling, Robert L.; Calabrese, Joseph R.] Case Western Reserve Univ, Dept Psychiat, Univ Hosp Case Med Ctr, Cleveland, OH 44106 USA.
   [Ismail-Beigi, Faramarz] Case Western Reserve Univ, Cleveland VA Med Ctr, Dept Endocrinol, Cleveland, OH 44106 USA.
C3 University System of Ohio; Case Western Reserve University; Case Western
   Reserve University Hospital; University System of Ohio; Case Western
   Reserve University; US Department of Veterans Affairs; Veterans Health
   Administration (VHA); Louis Stokes Cleveland Veterans Affairs Medical
   Center
RP Kemp, DE (corresponding author), 10524 Euclid Ave,12th Floor, Cleveland, OH 44106 USA.
EM kemp.david@gmail.com
RI Gao, Keming/W-6017-2019
FU NIH [1KL2RR024990]; National Center for Research Resources (NCRR), a
   component of the National Institutes of Health (NIH) [UL1 RR024989];
   Abbott; AstraZeneca; Bristol-Myers Squibb/Otsuka; Cephalon; Dainippon
   Sumitomo; Forest; GlaxoSmithKline; Janssen; Lilly; Lundbeck; Pfizer;
   Schering-Plough; Servier; Solvay; Sanofi; Synosia; Supernus
   Pharmaceuticals; Takeda; Wyeth; Eli Lilly
FX Funding for this study was provided in part by NIH grant 1KL2RR024990 to
   Dr. Kemp. The project described was supported by Grant Number UL1
   RR024989 from the National Center for Research Resources (NCRR), a
   component of the National Institutes of Health (NIH). The content of
   this article is solely the responsibility of the authors and does not
   necessarily represent the official view of NCRR or NIH. Takeda
   Pharmaceuticals Inc. supplied the study medication for use in this
   trial.Dr. Calabrese has received grant support, lecture honoraria, or
   has participated in advisory boards with Abbott, AstraZeneca,
   Bristol-Myers Squibb/Otsuka, Cephalon, Dainippon Sumitomo, Forest,
   GlaxoSmithKline, Janssen, Lilly, Lundbeck, Pfizer, Schering-Plough,
   Servier, Solvay, Sanofi, Synosia, Supernus Pharmaceuticals, Takeda and
   Wyeth.Dr. Ganocy receives grant support from AstraZeneca and Eli Lilly.
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NR 52
TC 86
Z9 93
U1 1
U2 21
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD FEB
PY 2012
VL 136
IS 3
BP 1164
EP 1173
DI 10.1016/j.jad.2011.06.033
PG 10
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA 915AT
UT WOS:000301996000131
PM 21782251
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Jacka, FN
   Maes, M
   Pasco, JA
   Williams, LJ
   Berk, M
AF Jacka, Felice N.
   Maes, Michael
   Pasco, Julie A.
   Williams, Lana J.
   Berk, Michael
TI Nutrient intakes and the common mental disorders in women
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Depression; Anxiety; Psychiatric; Diet; Nutrients; Nutrition
ID C-REACTIVE PROTEIN; POLYUNSATURATED FATTY-ACIDS; LOWER SERUM ZINC;
   FORCED SWIM TEST; ANTIDEPRESSANT-LIKE; DEPRESSIVE SYMPTOMS; MAJOR
   DEPRESSION; HOMOCYSTEINE LEVELS; METABOLIC SYNDROME; MAGNESIUM INTAKE
AB Background: There is an increasing recognition of the role of nutrition in depression and anxiety. Magnesium, folate and zinc have all been implicated in depressive illness, however there are few data on these nutrients in anxiety disorders and the data from population-studies are limited.
   Aims: In a large, randomly-selected, population-based sample of women, this study aimed to examine the relationship between the dietary intakes of these three micronutrients and clinically determined depressive and anxiety disorders and symptoms.
   Methods: Nutrient intakes were determined using a validated food frequency questionnaire. The General Health Questionnaire-12 measured psychological symptoms, and a clinical interview (Structured Clinical Interview for DSM-IV-TR, non-patient edition) assessed current depressive and anxiety disorders.
   Results: After adjustments for energy intake, each standard deviation increase in the intake of zinc, magnesium and folate was associated with reduced odds ratio (OR) for major depression/dysthymia (zinc: OR = 0.52. 95% confidence interval (Cl) 0.31 to 0.88; magnesium: OR = 0.60, 95% Cl 0.37 to 0.96: folate: OR = 0.66, 95% Cl 0.45 to 0.97). There was also an inverse association between the intake of magnesium and zinc and GHQ-12 scores (zinc: Z beta = -0.16, 95% Cl -0.29 to -0.04: magnesium: -0.14. 95% Cl -026 to -0.03). These relationships were not confounded by age. socioeconomic status, education or other health behaviours. There was no relationship observed between any nutrient and anxiety disorders.
   Conclusion: These results demonstrate an association between the dietary intakes of magnesium, folate and zinc and depressive illnesses, although reverse causality and/or confounding cannot be ruled out as explanations. (C) 2012 Elsevier B.V. All rights reserved.
C1 [Jacka, Felice N.; Williams, Lana J.; Berk, Michael] Deakin Univ, Barwon Psychiat Res Unit, Sch Med, Geelong, Vic 3217, Australia.
   [Jacka, Felice N.; Williams, Lana J.; Berk, Michael] Univ Melbourne, Dept Psychiat, Melbourne, Vic 3010, Australia.
   [Maes, Michael] Piyavate Hosp, Bangkok, Thailand.
   [Pasco, Julie A.] Deakin Univ, Barwon Epidemiol & Biostat Unit, Sch Med, Geelong, Vic 3217, Australia.
   [Pasco, Julie A.] Univ Melbourne, Dept Med, NW Acad Ctr, Melbourne, Vic 3010, Australia.
   [Berk, Michael] Univ Melbourne, Orygen Youth Hlth, Melbourne, Vic 3010, Australia.
C3 Deakin University; University of Melbourne; Deakin University;
   University of Melbourne; Orygen, The National Centre of Excellence in
   Youth Mental Health; University of Melbourne
RP Jacka, FN (corresponding author), Deakin Univ, Barwon Psychiat Res Unit, Sch Med, Geelong, Vic 3217, Australia.
EM felice@barwonhealth.org.au
RI Jacka, Felice/ABE-6322-2020; Maes, Michael/B-8546-2011; Ackland,
   Julie/C-8607-2012; Berk, Michael/AGH-9427-2022; Jacka,
   Felice/D-9424-2012; Berk, Michael/M-7891-2013
OI Jacka, Felice/0000-0002-9825-0328; Berk, Michael/0000-0002-5554-6946;
   Williams, Lana/0000-0002-1377-1272; Maes, Michael/0000-0002-2012-871X
FU National Health and Medical Research Council of Australia [454356,
   251638]; Eli Lilly; University of Melbourne, Faculty of Medicine,
   Dentistry and Health Sciences; Australian Rotary Health; NHMRC [628912]
FX This study was funded by the National Health and Medical Research
   Council of Australia (Project Grants #454356, 251638) and an
   unrestricted educational grant from Eli Lilly. The University of
   Melbourne, Faculty of Medicine, Dentistry and Health Sciences and
   Australian Rotary Health provided postgraduate scholarships to FNJ and
   LJW. FNJ is supported by an NHMRC Post-doctoral Training Fellowship
   (#628912). The funding providers played no role in the design or conduct
   of the study; collection, management, analysis, and interpretation of
   the data; or in preparation, review, or approval of the manuscript.
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NR 62
TC 122
Z9 133
U1 0
U2 44
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD DEC 1
PY 2012
VL 141
IS 1
BP 79
EP 85
DI 10.1016/j.jad.2012.02.018
PG 7
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA 011EV
UT WOS:000309148500010
PM 22397891
DA 2025-06-11
ER

PT J
AU Maria, P
   Martta, K
   Jouko, M
   Juha, A
   Marjo-Riitta, J
   Peter, BJ
   Mika, G
   Juha, V
AF Maria, Protsenko
   Martta, Kerkela
   Jouko, Miettunen
   Juha, Auvinen
   Marjo-Riitta, Jarvelin
   Peter, B. Jones
   Mika, Gissler
   Juha, Veijola
TI Insulin resistance and lipid levels in the middle-aged offspring of
   parents with severe mental illness
SO SCHIZOPHRENIA RESEARCH
LA English
DT Article
DE Mental illness; Birth cohort; Insulin resistance; Insulin sensitivity
ID IMPAIRED GLUCOSE-TOLERANCE; DRUG-NAIVE PATIENTS; METABOLIC SYNDROME;
   SCHIZOPHRENIA; OBESITY; RISK; ASSOCIATION; CHILDHOOD; EDUCATION;
   CHILDREN
AB Background: Type 2 diabetes and dyslipidemias co-occur frequently with severe mental illnesses (SMI). However, less is known about serum insulin and lipid levels and prevalence of Insulin Resistance (IR) in offspring with familial risk for SMI.Method: The Northern Finland Birth Cohort 1966 consists of 12,068 mothers, 11,068 fathers, and 12,231 children from the two northernmost provinces in Finland. At age 46 they participated in clinical examination including measurements of glucose, lipids, and IR and answered a questionnaire including information about their nutrition and physical activity. The information on parental SMI was obtained from the Hospital Discharge Register. Parents with SMI were those who had been treated in hospital for any psychiatric disorder during 1969-1982 (ICD-8 codes 290-315). The final study group included 334 (7.3 %) offspring who had a parent with SMI and 4249 (92.7 %) offspring in the comparison group.Results: We did not find increased risk for disturbances in lipid levels, insulin levels, or IR levels between the study group (offspring of either parent with SMI) compared with the comparison group. All offspring, especially female offspring of either parent with SMI, had an increased risk for higher glucose levels and waist circum-ference. The results remained the same after excluding offspring with SMI. Conclusion: Our findings suggest that offspring of parents with SMI, especially female offspring, have partly increased risk for disturbances in cardiometabolic risk factors. Disturbances in glucose metabolism may have an effect via familial risk of severe mental illness.
C1 [Maria, Protsenko; Martta, Kerkela; Juha, Veijola] Univ Oulu, Dept Psychiat, Res Unit Clin Neurosci, Oulu, Finland.
   [Jouko, Miettunen; Juha, Auvinen; Marjo-Riitta, Jarvelin] Univ Oulu, Res Unit Populat Hlth, Oulu, Finland.
   [Jouko, Miettunen; Juha, Veijola] Oulu Univ Hosp, Med Res Ctr Oulu, Oulu, Finland.
   [Jouko, Miettunen; Juha, Veijola] Univ Oulu, Oulu, Finland.
   [Mika, Gissler] Finnish Inst Hlth & Welf, Dept Knowledge Brokers, THL, Helsinki, Finland.
   [Mika, Gissler] Univ Turku, Res Ctr Child Psychiat, Turku, Finland.
   [Mika, Gissler] Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden.
   [Juha, Veijola] Univ Hosp Oulu, Dept Psychiat, Oulu, Finland.
   [Peter, B. Jones] Univ Cambridge, Dept Psychiat, Cambridge, England.
   [Maria, Protsenko] Univ Oulu, Peltolantie 17, Oulu 90014, Finland.
C3 University of Oulu; University of Oulu; University of Oulu; University
   of Oulu; Finland National Institute for Health & Welfare; University of
   Turku; Karolinska Institutet; University of Cambridge; University of
   Oulu
RP Maria, P (corresponding author), Univ Oulu, Peltolantie 17, Oulu 90014, Finland.
EM maria.protsenko@oulu.fi
OI Kerkela, Martta/0000-0002-1181-2632
FU University of Oulu [24000692]; Oulu University Hospital [24301140]; ERDF
   European Regional Development Fund [539/2010 A31592]
FX NFBC 1966 received financial support from the University of Oulu Grant
   no. 24000692, Oulu University Hospital Grant no. 24301140, ERDF European
   Regional Development Fund Grant no. 539/2010 A31592.
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NR 41
TC 2
Z9 2
U1 0
U2 0
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0920-9964
EI 1573-2509
J9 SCHIZOPHR RES
JI Schizophr. Res.
PD FEB
PY 2023
VL 252
BP 271
EP 278
DI 10.1016/j.schres.2023.01.013
EA JAN 2023
PG 8
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA C8CA1
UT WOS:000964121100001
PM 36696701
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Jabri, MA
   Rtibi, K
   Sebai, H
AF Jabri, Mohamed-Amine
   Rtibi, Kais
   Sebai, Hichem
TI Chamomile decoction mitigates high fat diet-induced anxiety-like
   behavior, neuroinflammation and cerebral ROS overload
SO NUTRITIONAL NEUROSCIENCE
LA English
DT Article
DE Obesity; chamomile; anxiety; hypercholezterolaemia; neuroinflammation
ID MATRICARIA-RECUTITA; OXIDATIVE STRESS; LIPID-PROFILE; OBESE RATS;
   EXTRACT; MODEL; LIPOTOXICITY; ANTIOXIDANT; MECHANISM; EFFICACY
AB An abundant literature suggests that obesity-associated with taking a high fat diet is related to an elevated risk of type 2 diabetes and metabolic syndrome. However, metabolic disorders may be involved in the induction of the anxiogenic-like symptoms. The current study was designed to elucidate the mechanisms by which a high fat diet (HFD) can cause several complications in the WISTAR rats (Rattus norvegicus) brain. Oxidative stress and inflammation as well as the putative protection afforded by chamomile decoction extract (CDE) were also studied.
   The results demonstrated that the increased body and brain weight, acetylcholinesterase and butyrylcholinesterase activities as well as hypercholezterolaemia in response to HFD taking were correlated with anxiogenic-like symptoms. Moreover, HFD feed caused a brain oxidative stress characterized by increased lipoperoxidation, inhibition of antioxidant enzyme activities such as SOD, CAT and GPx, depletion of a non-enzymatic antioxidant such as sulfhydryl groups and GSH. Importantly, the results also show that HFD also provoked a cerebral overload in reactive oxygen species such as OH center dot, H2O2 and O-2(center dot-) as well as brain inflammation assessed by the overproduction of cytokines such as IL-1 beta and IL-6.
   Interestingly, all neurobehavioral changes and all the biochemical and molecular disturbances were abolished in HFD-fed rats treated with CDE.
   Our results provide clear evidence that obesity and depression as well as anxiety are finely correlated and that M. recutita's decoction may prove to be a potential therapeutic agent to mitigate the behavioral disorders, the biochemical alterations and the neuroinflammation associated to the obesity.
C1 [Jabri, Mohamed-Amine; Rtibi, Kais; Sebai, Hichem] Univ Jendouba, Unite Physiol Fonct & Valorisat Bioressources, Inst Super Biotechnol Beja, Ave Habib Bourguiba BP 382, Beja 9000, Tunisia.
C3 Universite de Jendouba
RP Jabri, MA (corresponding author), Univ Jendouba, Unite Physiol Fonct & Valorisat Bioressources, Inst Super Biotechnol Beja, Ave Habib Bourguiba BP 382, Beja 9000, Tunisia.
EM jabri.amino@gmail.com
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NR 87
TC 19
Z9 19
U1 0
U2 13
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1028-415X
EI 1476-8305
J9 NUTR NEUROSCI
JI Nutr. Neurosci.
PD JUL 3
PY 2022
VL 25
IS 7
BP 1350
EP 1361
DI 10.1080/1028415X.2020.1859727
EA DEC 2020
PG 12
WC Neurosciences; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Nutrition & Dietetics
GA 2G3HA
UT WOS:000598544900001
PM 33314994
DA 2025-06-11
ER

PT J
AU Castillo, EG
   Rosati, J
   Williams, C
   Pessin, N
   Lindy, DC
AF Castillo, Enrico G.
   Rosati, Justin
   Williams, Caroline
   Pessin, Neil
   Lindy, David C.
TI Metabolic Syndrome Screening and Assertive Community Treatment: A
   Quality Improvement Study
SO JOURNAL OF THE AMERICAN PSYCHIATRIC NURSES ASSOCIATION
LA English
DT Article
DE ACT/PACT; chronic mental illness; community mental health services;
   quality improvement; evidence-based practice
ID SCHIZOPHRENIA; PEOPLE; HEALTH; RISK; ANTIPSYCHOTICS; ASSOCIATION;
   PREVALENCE; MORTALITY; THERAPY
AB Metabolic syndrome defines a collection of cardiometabolic illnesses that predict risk for poor physical health and early death and is highly prevalent among those with serious mental illness. Despite recommendations for routine monitoring, those with serious mental illness frequently do not receive physical health screenings. We conducted a quality improvement (QI) project to increase rates of metabolic syndrome screening in three New York City Assertive Community Treatment (ACT) teams. The project, conducted from December 2010 to May 2011, involved educational sessions for staff and consumers and a systematic screening protocol. We collected complete metabolic syndrome screening measurements for 71% of participating ACT consumers. We found metabolic risk to be nearly universal among participants, with over half diagnosed with metabolic syndrome. We also found high rates of previously undiagnosed hypertension, diabetes, and dyslipidemia. We describe the resources and obstacles we encountered in our QI project to make systematic metabolic screening a routine part of ACT care. This QI project suggests that ACT teams can take a leadership role in screening their consumers for physical health issues, aligning with recent policy trends to better integrate behavioral health and primary care services.
C1 [Castillo, Enrico G.; Lindy, David C.] Columbia Univ, Med Ctr, New York, NY USA.
   [Castillo, Enrico G.; Lindy, David C.] New York State Psychiat Inst & Hosp, New York, NY 10032 USA.
   [Rosati, Justin] Hofstra North Shore Long Isl Jewish Sch Med, Hempstead, NY USA.
   [Williams, Caroline; Pessin, Neil; Lindy, David C.] Visiting Nurse Serv New York, New York, NY 10001 USA.
C3 Columbia University; New York State Psychiatry Institute; Hofstra
   University
RP Lindy, DC (corresponding author), Visiting Nurse Serv New York, 1250 Broadway, New York, NY 10001 USA.
EM David.Lindymd@vnsny.org
RI Castillo, Enrico/AAH-1862-2019
OI Castillo, Enrico G./0000-0002-3807-1125
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NR 39
TC 12
Z9 17
U1 0
U2 15
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1078-3903
EI 1532-5725
J9 J AM PSYCHIAT NURSES
JI J. Am. Psych. Nurses Assoc.
PD JUL-AUG
PY 2015
VL 21
IS 4
BP 233
EP 243
DI 10.1177/1078390315598607
PG 11
WC Nursing; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Psychiatry
GA CP6PL
UT WOS:000360009700002
PM 26282669
DA 2025-06-11
ER

PT J
AU Kowalska, K
   Olejnik, A
AF Kowalska, Katarzyna
   Olejnik, Anna
TI Beneficial effects of cranberry in the prevention of obesity and related
   complications: Metabolic syndrome and diabetes - A review
SO JOURNAL OF FUNCTIONAL FOODS
LA English
DT Review
DE Cranberry; Obesity; Metabolic syndrome; Diabetes; Bioavailability
ID PLASMA ANTIOXIDANT CAPACITY; C-REACTIVE PROTEIN; HIGH-FAT;
   INSULIN-RESISTANCE; JUICE CONSUMPTION; OXIDATIVE STRESS; URSOLIC ACID;
   LIPID-METABOLISM; VITAMIN-C; INFLAMMATION
AB In recent years, obesity, metabolic syndrome and diabetes are becoming epidemic both in developed and developing countries. Recent experimental and clinical studies have raised interest in the potential health benefits of cranberry consumption in obesity and metabolic syndrome, which appear to be associated with the phytochemical composition of this fruit. Interestingly, cranberry administration has been reported to ameliorate dyslipidemia, hyperglycaemia and oxidative stress in individuals with the metabolic syndrome. This review focuses on the recent findings regarding beneficial effects of cranberry on obesity and metabolic syndrome, and discusses its potential mechanisms of action. The results of studies presented in this review have demonstrated that cranberry ameliorates insulin resistance and plasma lipid profile, decreases diet-induced weight gain and visceral obesity, and diminishes blood markers of oxidative stress. Thus, cranberry could be an effective and safe component of functional foods addressed for individuals with metabolic complications. (C) 2015 Elsevier Ltd. All rights reserved.
C1 [Kowalska, Katarzyna; Olejnik, Anna] Poznan Univ Life Sci, Dept Biotechnol & Food Microbiol, Wojska Polskiego 48, PL-60627 Poznan, Poland.
C3 Poznan University of Life Sciences
RP Kowalska, K; Olejnik, A (corresponding author), Poznan Univ Life Sci, Dept Biotechnol & Food Microbiol, Wojska Polskiego 48, PL-60627 Poznan, Poland.
EM kaskakow@up.poznan.pl; aolejnik@up.poznan.pl
RI Kowalska, Katarzyna/AAC-7968-2021
OI Kowalska, Katarzyna/0000-0001-7706-4035; Olejnik,
   Anna/0000-0002-4385-0051
FU European Regional Development Fund [01.01.02-00-061/09]
FX Funding for this review was provided by the European Regional
   Development Fund (Project No. 01.01.02-00-061/09).
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NR 84
TC 47
Z9 49
U1 3
U2 44
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1756-4646
EI 2214-9414
J9 J FUNCT FOODS
JI J. Funct. Food.
PD JAN
PY 2016
VL 20
BP 171
EP 181
DI 10.1016/j.jff.2015.11.001
PG 11
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA DL4VC
UT WOS:000375634900016
DA 2025-06-11
ER

PT J
AU Vega-Rivera, NM
   Estrada-Camarena, E
   Azpilcueta-Morales, G
   Cervantes-Anaya, N
   Treviño, S
   Becerril-Villanueva, E
   Lopez-Rubalcava, C
AF Vega-Rivera, Nelly Maritza
   Estrada-Camarena, Erika
   Azpilcueta-Morales, Gabriel
   Cervantes-Anaya, Nancy
   Trevino, Samuel
   Becerril-Villanueva, Enrique
   Lopez-Rubalcava, Carolina
TI Chronic Variable Stress and Cafeteria Diet Combination Exacerbate
   Microglia and c-fos Activation but Not Experimental Anxiety or
   Depression in a Menopause Model
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE chronic variable stress; menopause model; obesity; anxiety; Iba-positive
   cells; c-fos
ID HIGH-FAT DIET; ADULT HIPPOCAMPAL NEUROGENESIS; FORCED SWIMMING TEST;
   METABOLIC SYNDROME; SEX-DIFFERENCES; DENTATE GYRUS; CELL-SURVIVAL;
   WISTAR RATS; ESTROGEN; BRAIN
AB The menopause transition is a vulnerable period for developing both psychiatric and metabolic disorders, and both can be enhanced by stressful events worsening their effects. The present study aimed to evaluate whether a cafeteria diet (CAF) combined with chronic variable stress (CVS) exacerbates anxious- or depressive-like behavior and neuronal activation, cell proliferation and survival, and microglia activation in middle-aged ovariectomized (OVX) rats. In addition, body weight, lipid profile, insulin resistance, and corticosterone as an index of metabolic changes or hypothalamus-pituitary-adrenal (HPA) axis activation, and the serum pro-inflammatory cytokines IL-6, IL-beta, and TNF alpha were measured. A CAF diet increased body weight, lipid profile, and insulin resistance. CVS increased corticosterone and reduced HDL. A CAF produced anxiety-like behaviors, whereas CVS induced depressive-like behaviors. CVS increased serum TNF alpha independently of diet. A CAF and CVS separately enhanced the percentage of Iba-positive cells in the hippocampus; the combination of factors further increased Iba-positive cells in the ventral hippocampus. A CAF and CVS increased the c-fos-positive cells in the hippocampus; the combination of factors increased the number of positive cells expressing c-fos in the ventral hippocampus even more. The combination of a CAF and CVS generates a slight neuroinflammation process and neuronal activation in a hippocampal region-specific manner and differentially affects the behavior.
C1 [Vega-Rivera, Nelly Maritza; Estrada-Camarena, Erika; Azpilcueta-Morales, Gabriel; Cervantes-Anaya, Nancy] Inst Nacl Psiquiatria Ramon de la Fuente, Lab Neuropsicofarmacol, Direcc Neurociencias, Mexico City 14370, Mexico.
   [Trevino, Samuel] Benemerita Univ Puebla, Fac Quim, Puebla 72570, Mexico.
   [Becerril-Villanueva, Enrique] Inst Nacl Psiquiatria Ramon de la Fuente, Lab Psicoinmunol, Direcc Neurociencias, Mexico City 14370, Mexico.
   [Lopez-Rubalcava, Carolina] Ctr Invest & Estudios Avanzados IPN, Dept Farmacobiol, Mexico City 14330, Mexico.
C3 Instituto Nacional de Psiquiatria Ramon de la Fuente Muniz; Benemerita
   Universidad Autonoma de Puebla; Instituto Nacional de Psiquiatria Ramon
   de la Fuente Muniz; CINVESTAV - Centro de Investigacion y de Estudios
   Avanzados del Instituto Politecnico Nacional
RP Estrada-Camarena, E (corresponding author), Inst Nacl Psiquiatria Ramon de la Fuente, Lab Neuropsicofarmacol, Direcc Neurociencias, Mexico City 14370, Mexico.
EM vegquim2909@gmail.com; estrada@imp.edu.mx; sinhueazpilcueta@gmail.com;
   qfb.nancy.cervantes@hotmail.com; samuel_trevino@hotmail.com;
   lusenbeve@yahoo.com; clopezr@cinvestav.mx
RI /F-8947-2018; Lopez-Rubalcava, Carolina/A-7056-2008
OI /0000-0001-6634-7494; Azpilcueta Morales, Gabriel
   Sinhue/0000-0002-7605-1045; Cervantes Anaya, Nancy/0000-0002-4751-0249;
   Lopez-Rubalcava, Carolina/0000-0002-9562-7193
FU Consejo Nacional de Humanidades, Ciencia y Tecnologias (CONAHCyT)
   [CB-241247]
FX This research was funded by Consejo Nacional de Humanidades, Ciencia y
   Tecnologias (CONAHCyT), grant number CB-241247 to E.E.-C.
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NR 79
TC 1
Z9 1
U1 1
U2 2
PU MDPI
PI BASEL
PA Gross-peteranlage 5, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD FEB
PY 2024
VL 25
IS 3
AR 1455
DI 10.3390/ijms25031455
PG 17
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA HR2E2
UT WOS:001161159600001
PM 38338735
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Guénard, F
   Lamontagne, M
   Bossé, Y
   Deshaies, Y
   Cianflone, K
   Kral, JG
   Marceau, P
   Vohl, MC
AF Guenard, Frederic
   Lamontagne, Maxime
   Bosse, Yohan
   Deshaies, Yves
   Cianflone, Katherine
   Kral, John G.
   Marceau, Picard
   Vohl, Marie-Claude
TI Influences of Gestational Obesity on Associations between Genotypes and
   Gene Expression Levels in Offspring following Maternal Gastrointestinal
   Bypass Surgery for Obesity
SO PLOS ONE
LA English
DT Article
ID WHITE ADIPOSE-TISSUE; BODY-MASS INDEX; WEIGHT-LOSS; METABOLIC SYNDROME;
   PRENATAL EXPOSURE; ENZYME EXPRESSION; RISK-FACTORS; METHYLATION;
   COMPONENTS; VARIANTS
AB Maternal obesity and excess gestational weight gain with compromised metabolic fitness predispose offspring to lifelong obesity and its comorbidities. We demonstrated that compared to offspring born before maternal gastrointestinal bypass surgery (BMS) those born after (AMS) were less obese, with less cardiometabolic risk reflected in the expression and methylation of diabetes, immune and inflammatory pathway genes. Here we examine relationships between gestational obesity and offspring gene variations on expression levels.
   Methods
   Whole-genome genotyping and gene expression analyses in blood of 22 BMS and 23 AMS offspring from 19 mothers were conducted using Illumina HumanOmni-5-Quad and HumanHT-12 v4 Expression BeadChips, respectively. Using PLINK we analyzed interactions between offspring gene variations and maternal surgical status on offspring gene expression levels. Altered biological functions and pathways were identified and visualized using DAVID and Ingenuity Pathway Analysis.
   Results
   Significant interactions (p <= 1.22x10(-12)) were found for 525 among the 16,060 expressed transcripts: 1.9% of tested SNPs were involved. Gene function and pathway analysis demonstrated enrichment of transcription and of cellular metabolism functions and overrepresentation of cellular stress and signaling, immune response, inflammation, growth, proliferation and development pathways.
   Conclusion
   We suggest that impaired maternal gestational metabolic fitness interacts with offspring gene variations modulating gene expression levels, providing potential mechanisms explaining improved cardiometabolic risk profiles of AMS offspring related to ameliorated maternal lipid and carbohydrate metabolism.
C1 [Guenard, Frederic; Vohl, Marie-Claude] Univ Laval, Inst Nutr & Funct Foods INAF, Quebec City, PQ G1K 7P4, Canada.
   [Guenard, Frederic; Vohl, Marie-Claude] Univ Laval, Dept Food Sci & Nutr, Quebec City, PQ G1K 7P4, Canada.
   [Guenard, Frederic; Vohl, Marie-Claude] CHU, Quebec Res Ctr, Quebec City, PQ, Canada.
   [Lamontagne, Maxime; Bosse, Yohan; Deshaies, Yves; Cianflone, Katherine; Marceau, Picard] Quebec Heart & Lung Inst, Quebec City, PQ, Canada.
   [Bosse, Yohan] Univ Laval, Dept Mol Med, Quebec City, PQ G1K 7P4, Canada.
   [Deshaies, Yves; Cianflone, Katherine] Univ Laval, Dept Med, Quebec City, PQ G1K 7P4, Canada.
   [Kral, John G.] Suny Downstate Med Ctr, Dept Surg, Brooklyn, NY 11203 USA.
   [Marceau, Picard] Univ Laval, Dept Surg, Quebec City, PQ G1K 7P4, Canada.
C3 Laval University; Laval University; Laval University; Laval University
   Hospital; Quebec Heart & Lung Institute; Laval University; Laval
   University; State University of New York (SUNY) System; SUNY Downstate
   Health Sciences University; Laval University
RP Vohl, MC (corresponding author), Univ Laval, Inst Nutr & Funct Foods INAF, Quebec City, PQ G1K 7P4, Canada.
EM marie-claude.vohl@fsaa.ulaval.ca
RI Vohl, Marie-Claude/AAQ-1378-2021
OI Vohl, Marie-Claude/0000-0002-7017-5848; Lamontagne,
   Maxime/0000-0001-6674-4983
FU Canadian Institutes of Health Research [CIHR MOP-209380]
FX This study was supported by a grant from the Canadian Institutes of
   Health Research (CIHR MOP-209380; http://www.cihr-irsc.gc.ca). The
   funder had no role in study design, data collection and analysis,
   decision to publish, or preparation of the manuscript.
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NR 69
TC 6
Z9 7
U1 0
U2 4
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JAN 20
PY 2015
VL 10
IS 1
AR e0117011
DI 10.1371/journal.pone.0117011
PG 17
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA AZ4OZ
UT WOS:000348203500041
PM 25603303
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Rosas, LG
   Vasquez, JJ
   Naderi, R
   Jeffery, N
   Hedlin, H
   Qin, FF
   LaFromboise, T
   Megginson, N
   Pasqua, C
   Flores, O
   McClinton-Brown, R
   Evans, J
   Stafford, RS
AF Rosas, Lisa G.
   Vasquez, Jan J.
   Naderi, Ramin
   Jeffery, Nicole
   Hedlin, Haley
   Qin, FeiFei
   LaFromboise, Teresa
   Megginson, Nancy
   Pasqua, Craig
   Flores, Orena
   McClinton-Brown, Rhonda
   Evans, Jill
   Stafford, Randall S.
TI Development and evaluation of an enhanced diabetes prevention program
   with psychosocial support for urban American Indians and Alaska natives:
   A randomized controlled trial
SO CONTEMPORARY CLINICAL TRIALS
LA English
DT Article
DE American Indian; Diabetes prevention; Prediabetes; Obesity;
   Community-based participatory research; Weight loss
ID LIFE-STYLE INTERVENTION; HISTORICAL-TRAUMA; COMMUNITY-HEALTH;
   CLINICAL-TRIALS; TALKING CIRCLES; RISK-FACTORS; OBESITY; MODEL;
   FACILITATORS; METHODOLOGY
AB Diabetes is highly prevalent, affecting over 25 million adults in the US, yet it can be effectively prevented through lifestyle interventions, including the well-tested Diabetes Prevention Program (DPP). American Indian/Alaska Native (ALAN) adults, the majority of whom live in urban settings, are more than twice as likely to develop diabetes as non-Hispanic whites. Additionally, prevalent mental health issues and psychosocial stressors may facilitate progression to diabetes and hinder successful implementation of lifestyle interventions for ALAN adults. This 2-phased study first engaged community stakeholders to develop culturally-tailored strategies to address mental health concerns and psychosocial stressors. Pilot testing (completed) refined those strategies that increase engagement in an enhanced DPP for urban ALAN adults. Second, the enhanced DPP will be compared to a standard DPP in a randomized controlled trial (ongoing) with a primary outcome of body mass index (BMI) and a secondary outcome of quality of life (QoL) over 12 months. Obese self-identified ALAN adults residing in an urban setting with one or more components of the metabolic syndrome (excluding waist circumference) will be randomized to the enhanced or standard DPP (n = 204). We hypothesize that addressing psychosocial barriers within a culturally-tailored DPP will result in clinical (BMI) and superior patient-centered (QoL) outcomes as compared to a standard DPP. Exploratory outcomes will include cardiometabolic risk factors (e.g., waist circumference, blood pressure, fasting glucose) and health behaviors (e.g., diet, physical activity). Results of this trial may be applicable to other urban ALAN or minority communities or even diabetes prevention in general. (C) 2016 Elsevier Inc. All rights reserved.
C1 [Rosas, Lisa G.; McClinton-Brown, Rhonda; Evans, Jill] Palo Alto Med Fdn, 795 El Camino Real, Palo Alto, CA 94301 USA.
   [Rosas, Lisa G.] Stanford Prevent Res Ctr, Stanford Dept Med, Stanford, CA USA.
   [Vasquez, Jan J.; Naderi, Ramin; Megginson, Nancy; Pasqua, Craig; Flores, Orena] Timpany Ctr, 730 Empey Way, San Jose, CA 95128 USA.
   [Jeffery, Nicole] Stanford Prevent Res Ctr, 1070 Arastradero Rd, Palo Alto, CA 94304 USA.
   [Hedlin, Haley; Qin, FeiFei] Stanford Univ, Dept Med, Quantitat Sci Unit, 1070 Arastradero Rd, Palo Alto, CA 94304 USA.
   [LaFromboise, Teresa] Stanford Univ, Grad Sch Educ, 485 Lasuen Mall, Stanford, CA 94305 USA.
   [Stafford, Randall S.] Stanford Prevent Res Ctr, Program Prevent Outcomes & Practices, 1265 Welch Rd, Stanford, CA 94305 USA.
C3 Palo Alto Medical Foundation Research Institute; Stanford University;
   Stanford University; Stanford University; Stanford University; Stanford
   University
RP Rosas, LG (corresponding author), Palo Alto Med Fdn, 795 El Camino Real, Palo Alto, CA 94301 USA.
EM lgrosas@stanford.edu; jan.vasquez@sjsu.edu; ramin.naderi@sjsu.edu;
   njeffery@stanford.edu; hedlin@stanford.edu; fqin@stanford.edu;
   lafrom@stanford.edu; nancy.megginson@sjsu.edu;
   craig@fourdirectionstennis.net; orenalm@hotmail.com;
   rstafford@stanford.edu
RI Stafford, Randall/KVA-6934-2024; Stafford, Randall/F-3974-2017
OI Goldman Rosas, Lisa/0000-0003-4053-7972; Hedlin,
   Haley/0000-0002-0757-7959; vasquez, jan/0000-0003-4912-3231;
   LaFromboise, Teresa/0000-0002-8301-6117; Stafford,
   Randall/0000-0003-1805-1271
FU Patient Centered Outcomes Research Institute (PCORI) Project [AD
   130602172]; NIH [UL1 RR025744, K24 HL086703]
FX The work was primarily supported through a Patient Centered Outcomes
   Research Institute (PCORI) Project Program Award AD 130602172.
   Additional support was obtained from UL1 RR025744 and K24 HL086703 from
   NIH. All statements in this report, including its findings and
   conclusions, are solely those of the authors and do not necessarily
   represent the views of the Patient-Centered Outcomes Research Institute
   (PCORI), its Board of Governors or Methodology Committee. No sponsor or
   funding source has a role in the design or conduct of the study;
   collection, management, analysis or interpretation of the data; or
   preparation, review or approval of the manuscript.
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NR 71
TC 11
Z9 15
U1 0
U2 25
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1551-7144
EI 1559-2030
J9 CONTEMP CLIN TRIALS
JI Contemp. Clin. Trials
PD SEP
PY 2016
VL 50
BP 28
EP 36
DI 10.1016/j.cct.2016.06.015
PG 9
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA DY7PM
UT WOS:000385321600005
PM 27381232
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Shaw, LJ
   Berman, DS
   Hendel, RC
   Alazraki, N
   Krawczynska, E
   Borges-Neto, S
   Maddahi, J
   Cerqueira, M
AF Shaw, Leslee J.
   Berman, Daniel S.
   Hendel, Robert C.
   Alazraki, Naomi
   Krawczynska, Elizabeth
   Borges-Neto, Salvador
   Maddahi, Jamshid
   Cerqueira, Manuel
TI Cardiovascular disease risk stratification with stress single-photon
   emission computed tomography technetium-99m tetrofosmin imaging in
   patients with the metabolic syndrome and diabetes mellitus
SO AMERICAN JOURNAL OF CARDIOLOGY
LA English
DT Article
ID INCREMENTAL PROGNOSTIC VALUE; CORONARY-ARTERY-DISEASE; ASYMPTOMATIC
   PATIENTS; MYOCARDIAL-ISCHEMIA; US ADULTS; PREVALENCE; ATHEROSCLEROSIS;
   SYMPTOMS; IMPACT; SCORE
AB The metabolic syndrome represents a constellation of risk factors caused by insulin resistance, dyslipidemia, hypertension, and obesity, resulting in elevated coronary disease risk. From a multicenter prospective registry of 7,849 patients, the relation among the metabolic syndrome, diabetes, and risk stratification with stress technetium-99m tetrofosmin single photon-emission computed tomography (SPECT) was evaluated. The percentage of stress myocardial defects was calculated as <= 5%, 5.1% to 10%, 10.1% to 15%, and, > 15%. A Cox proportional-hazards model was used to estimate cardiovascular death or myocardial infarction (n = 752). Of 7,849 patients, 42% had the metabolic syndrome. Patients with the metabolic syndrome had an 84% 2-year event-free survival rate, lower than patients with normal metabolic status (p < 0.0001). It! patients with the metabolic syndrome, the percentage of moderate to severely abnormal SPECT findings ranged from 11% to 44% for those with 3 to 5 risk factors for the metabolic syndrome. There was an additive relation between the number of risk factors for the metabolic syndrome and the extent and severity of abnormalities in SPECT findings (p < 0.0001). Patients with 5 risk factors for the metabolic syndrome were at the greatest risk, with hazard ratios from 7.8- to 14.1-fold for mild to severely abnormal SPECT findings. For diabetic patients requiring combined oral and insulin therapy, relative risk ratios increased from 15 to 21.4 for patients with > 5% to > 15% stress myocardial perfusion defects. In conclusion, cardiovascular prognosis is affected by the degree of metabolic dysfunction, and stress-induced reductions in myocardial perfusion provide an accurate means for near-term risk stratification. (c) 2006 Elsevier Inc. All rights reserved.
C1 Cedars Sinai Med Ctr, Los Angeles, CA 90048 USA.
   Emory Univ, Vet Affairs Med Ctr, Atlanta, GA 30322 USA.
   Duke Univ, Med Ctr, Durham, NC USA.
   Univ Calif Los Angeles, Med Ctr, Los Angeles, CA USA.
   Cleveland Clin Fdn, Cleveland, OH 44195 USA.
C3 Cedars Sinai Medical Center; US Department of Veterans Affairs; Veterans
   Health Administration (VHA); Atlanta VA Health Care System; Emory
   University; Duke University; University of California System; University
   of California Los Angeles; University of California Los Angeles Medical
   Center; Cleveland Clinic Foundation
RP Shaw, LJ (corresponding author), Cedars Sinai Med Ctr, Los Angeles, CA 90048 USA.
EM leslee.shaw@cshs.org
RI Shaw, Leslee/ABG-4621-2022; berman, daniel/ABF-0670-2022
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NR 29
TC 36
Z9 37
U1 0
U2 1
PU EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
PI BRIDGEWATER
PA 685 ROUTE 202-206 STE 3, BRIDGEWATER, NJ 08807 USA
SN 0002-9149
EI 1879-1913
J9 AM J CARDIOL
JI Am. J. Cardiol.
PD MAY 15
PY 2006
VL 97
IS 10
BP 1538
EP 1544
DI 10.1016/j.amjcard.2005.12.041
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 044YC
UT WOS:000237708600026
PM 16679101
DA 2025-06-11
ER

PT J
AU Jamiol-Milc, D
   Biernawska, J
   Liput, M
   Stachowska, L
   Domiszewski, Z
AF Jamiol-Milc, Dominika
   Biernawska, Jowita
   Liput, Magdalena
   Stachowska, Laura
   Domiszewski, Zdzislaw
TI Seafood Intake as a Method of Non-Communicable Diseases (NCD) Prevention
   in Adults
SO NUTRIENTS
LA English
DT Review
DE diet; seafood; elderly people; health; non-communicable diseases
ID POLYUNSATURATED FATTY-ACIDS; FARMED ATLANTIC SALMON;
   CORONARY-HEART-DISEASE; DOSE-RESPONSE METAANALYSIS; HERRING
   CLUPEA-HARENGUS; FUNCTIONAL AMINO-ACIDS; FISH CONSUMPTION; CANCER-RISK;
   METABOLIC SYNDROME; SEASONAL-CHANGES
AB Seafood (fish in particular) is one of the main food groups in nutrition models with proven health benefits. Seafood has long been considered a very valuable dietary component, mainly due to presence of n-3 polyunsaturated fatty acids (n-3 PUFA) but it is also an important source of protein (including collagen), anserine, taurine, iodine, selenium, vitamin A, vitamin K, vitamin D, tocopherols, B vitamins and astaxanthin. Considering the beneficial effects of these ingredients on blood pressure, lipid profile and the inflammatory process, seafood should be an essential component of the diet. Non-communicable diseases (NCD) such as cardiovascular diseases, cancer, diabetes and mental disorder, chronic respiratory diseases are common diseases associated with advanced age. Promotion of a healthy lifestyle (including proper nutritional behavior) and prevention of diseases are the most effective and efficient ways to decrease premature mortality from NCD and to maintain mental health and well-being. This review article shows the potential preventive and therapeutic effects of seafood with an emphasis on fish. Our narrative review presents the results of systematic reviews and meta-analysis.
C1 [Jamiol-Milc, Dominika] Pomeranian Med Univ, Dept Human Nutr & Metab, PL-71460 Szczecin, Poland.
   [Biernawska, Jowita] Pomeranian Med Univ, Dept Anaesthesiol & Intens Therapy, PL-71242 Szczecin, Poland.
   [Liput, Magdalena] Pomeranian Med Univ, Dept Pharmacognosy & Nat Med, PL-70111 Szczecin, Poland.
   [Stachowska, Laura] Pomeranian Med Univ, Dept Biochem Sci, PL-71460 Szczecin, Poland.
   [Domiszewski, Zdzislaw] Koszalin Univ Technol, Dept Food Ind Proc & Facil, PL-75620 Koszalin, Poland.
C3 Pomeranian Medical University; Pomeranian Medical University; Pomeranian
   Medical University; Pomeranian Medical University; Koszalin University
   of Technology
RP Jamiol-Milc, D (corresponding author), Pomeranian Med Univ, Dept Human Nutr & Metab, PL-71460 Szczecin, Poland.
EM dominika.jamiol@pum.edu.pl; jowita.biernawska@pum.edu.pl;
   mliput@pum.edu.pl; laura.stachowska@pum.edu.pl;
   zdzislaw.domiszewski@tu.koszalin.pl
RI Jamioł-Milc, Dominika/ABA-4267-2020; Domiszewski, Zdzislaw/I-9456-2016;
   Biernawska, Jowita/A-9938-2015; Jamiol-Milc, Dominika/U-9140-2018
OI Stachowska, Laura/0000-0002-3386-8645; Jamiol-Milc,
   Dominika/0000-0003-0203-1823; Domiszewski, Zdzislaw/0000-0001-9695-0665
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NR 135
TC 22
Z9 23
U1 4
U2 19
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD MAY
PY 2021
VL 13
IS 5
AR 1422
DI 10.3390/nu13051422
PG 17
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA ST3PF
UT WOS:000662359200001
PM 33922600
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Rees, M
   Nedeva-Petkova, M
   Hanna, A
   Breeze, J
AF Rees, Michael
   Nedeva-Petkova, Maya
   Hanna, Azad
   Breeze, Julian
TI Does Collecting Physiological Data Aid in the Diagnosis of Coronary
   Artery Disease by Nuclear Perfusion Single Photon Emission Computed
   Tomography Imaging?
SO JOURNAL OF MEDICAL IMAGING AND HEALTH INFORMATICS
LA English
DT Article
DE Nuclear Stress Perfusion Index; 12-Lead ECG Stress Test; MyoQuant Index;
   Cardiac Syndrome X
ID RESTING HEART-RATE; TREADMILL EXERCISE; SYNDROME-X; ADENOSINE INFUSION;
   ST DEPRESSION; CHEST-PAIN; STRESS-TEST; ECG; WOMEN; MORTALITY
AB This study examined whether ECG and physiological findings recorded during the stress component of cardiac 99mTc Sestamibi gated SPECT (single photon emission computed tomography) imaging add to the interpretation of the examination. 311 patients (161 male), mean age 66 years (range 31-89 years) were categorized as having myocardial perfusion either within the normal range expressed as the MyoQuant Index, (MQI <= 1) or abnormal perfusion (MQI > 1). Based on results from the continuous 12 lead ECG examination taken during the stress component of this examination, patients were determined to have either ST depression (ST-pos >= 1 mm) or no T changes (ST-neg) 42% of these patients showed ST depression greater than 1 mm. The results show no overall correlation between ST depression and abnormal perfusion. Examination of left ventricular cavity volumes and ejection fraction at rest and cardiovascular haemodynamics (systolic blood pressure, diastolic blood pressure, heart rate) at rest and during stress were carried out. Analysis of this data showed no significant difference between the groups, except for an effect, (p < .01), on the resting heart rate of patients (ST-pos, 86 bpm. (beats per minute). vs. ST-neg, 79 bpm.) and the maximal heart rate (p < .05) (ST-pos 126 bpm. vs. ST-neg. 119 bpm.). This suggests that-the heart rate of-patients should be recorded in this type of examination. Patients with a positive stress test result, and a completely normal perfusion rating, (MQI < 1) accounted for 9% of the total cohort (n = 29, 6 male).
C1 [Rees, Michael; Breeze, Julian] Bangor Univ, Sch Med Sci, Bangor LL57 2DG, Gwynedd, Wales.
   [Nedeva-Petkova, Maya] Betsi Cadwaladr Univ Hlth Board, Ysbyty Gwynedd, Dept Radiol, Bangor LL57 2DG, Gwynedd, Wales.
   [Hanna, Azad] Betsi Cadwaladr Univ Hlth Board, Ysbyty Gwynedd, Dept Cardiol, Bangor LL57 2DG, Gwynedd, Wales.
C3 Bangor University
RP Rees, M (corresponding author), Bangor Univ, Sch Med Sci, Bangor LL57 2DG, Gwynedd, Wales.
RI Breeze, Julian/B-4228-2014
OI Breeze, Julian/0000-0002-3058-476X
FU European School of Radiology (ESOR)
FX Dr. Maya Nedeva-Petkova took part in this study as part of an ESCR
   fellowship placement organized through the European School of Radiology
   (ESOR).
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NR 35
TC 1
Z9 1
U1 0
U2 1
PU AMER SCIENTIFIC PUBLISHERS
PI VALENCIA
PA 26650 THE OLD RD, STE 208, VALENCIA, CA 91381-0751 USA
SN 2156-7018
EI 2156-7026
J9 J MED IMAG HEALTH IN
JI J. Med. Imaging Health Inform.
PD FEB
PY 2015
VL 5
IS 1
BP 152
EP 157
DI 10.1166/jmihi.2015.1371
PG 6
WC Mathematical & Computational Biology; Radiology, Nuclear Medicine &
   Medical Imaging
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Mathematical & Computational Biology; Radiology, Nuclear Medicine &
   Medical Imaging
GA CA0SW
UT WOS:000348627700022
DA 2025-06-11
ER

PT J
AU Duruöz, MT
   Turan, Y
   Gürgan, A
   Deveci, H
AF Duruoz, Mehmet Tuncay
   Turan, Yasemin
   Gurgan, Alev
   Deveci, Hulya
TI Evaluation of metabolic syndrome in patients with chronic low back pain
SO RHEUMATOLOGY INTERNATIONAL
LA English
DT Article
DE Low back pain; Metabolic syndrome; Clinical findings
ID NECROSIS-FACTOR-ALPHA; RISK-FACTORS; OBESITY; POPULATION; COMPONENTS
AB The aim of our study was to investigate the frequency of the metabolic syndrome in chronic low back pain and evaluate the differences in clinical and functional parameters in chronic low back pain patients with and without metabolic syndrome. Patients complaining of low back pain complaint lasting for at least 2 months were included in the study. In order to establish functional deficiency, Roland-Morris Disability Questionnaire, Istanbul Low Back Pain Disability Index and Oswestry Disability Index were used. To evaluate depression, Beck's depression scale was used. The diagnosis of metabolic syndrome was made according to the criteria of National Cholesterol Education Program (NCEP) defined in 2001. For this; lumbar circumference around anterior iliac spine, arterial blood pressure, fasting blood glucose, plasma triglyceride levels and HDL cholesterol levels were noted down. Sixty patients (51 women) were included in the study. There was significant difference in terms of BMI (P = 0.034), age (P = 0.001), waist circumference (P = 0.048) and disease duration (P = 0.005) between chronic low back pain patients with and without metabolic syndrome. There was no significant difference in other parameters. Low back pain is a frequent complaint amongst people with obesity in the abdominal area. According to our results, elderly people, people with chronic low back pain and patients with high BMI are under risk for metabolic syndrome. For this reason this group of patients can be screened for metabolic syndrome and preventive measures can be taken.
C1 [Turan, Yasemin] Adnan Menderes Univ, Sch Med, PM&R Dept, Aydin, Turkey.
   [Duruoz, Mehmet Tuncay] Celal Bayar Univ, Sch Med, PM&R Dept, Div Rheumatol, Manisa, Turkey.
   [Gurgan, Alev; Deveci, Hulya] Ataturk Training & Res Hosp, Dept Phys Med & Rehabil, Izmir, Turkey.
C3 Adnan Menderes University; Celal Bayar University; Izmir Ataturk
   Training & Research Hospital
RP Turan, Y (corresponding author), Adnan Menderes Univ, Sch Med, PM&R Dept, Aydin, Turkey.
EM dryaseminturan@gmail.com
RI Duruoz, Mehmet Tuncay/I-2307-2016
OI Duruoz, Mehmet Tuncay/0000-0003-3584-2788
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NR 31
TC 18
Z9 19
U1 0
U2 16
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0172-8172
EI 1437-160X
J9 RHEUMATOL INT
JI Rheumatol. Int.
PD MAR
PY 2012
VL 32
IS 3
BP 663
EP 667
DI 10.1007/s00296-010-1693-x
PG 5
WC Rheumatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Rheumatology
GA 902NB
UT WOS:000301044100014
PM 21132549
DA 2025-06-11
ER

PT J
AU So, H
   Tam, LS
AF So, Ho
   Tam, Lai-Shan
TI Cardiovascular disease and depression in psoriatic arthritis:
   Multidimensional comorbidities requiring multidisciplinary management
SO BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY
LA English
DT Article
DE Psoriatic arthritis; Cardiovascular disease; Depression
ID NONSTEROIDAL ANTIINFLAMMATORY DRUGS; METABOLIC SYNDROME; SUBCLINICAL
   ATHEROSCLEROSIS; RHEUMATOID-ARTHRITIS; RISK-FACTORS; DIABETES-MELLITUS;
   CORONARY PLAQUE; INFLAMMATION; ANXIETY; EVENTS
AB Psoriatic arthritis (PsA) is a chronic systemic inflammatory disease. The control of joint and skin manifestations has improved tremendously with the advent of the targeted therapies in the past decade. However, the occurrence of PsA is frequently accompanied by metabolic diseases, cardiovascular diseases (CVD), and depression. They are often unrecognized or undertreated, which leads to significant morbidities and even mortality. PsA predisposes patients to these important commodities through a number of mechanisms and their complex interaction, including chronically overexpressed inflammatory cytokines, a high prevalence of traditional CVD risk factors, the impact of pharmacotherapies, and a significant psychological burden. Herein, we review and discuss evidence on the epidemiology, pathophysiology, and assessment of CVD as well as depression in patients with PsA. Lastly, a multidisciplinary management approach to this multifaceted disease is presented. (c) 2021 Elsevier Ltd. All rights reserved.
C1 [So, Ho; Tam, Lai-Shan] Chinese Univ Hong Kong, Dept Med & Therapeut, Div Rheumatol, Hong Kong, Peoples R China.
C3 Chinese University of Hong Kong
RP Tam, LS (corresponding author), Chinese Univ Hong Kong, Prince Wales Hosp, Dept Med & Therapeut, Shatin, Hong Kong, Peoples R China.
EM lstam@cuhk.edu.hk
RI Tam, Lai-Shan/K-4980-2014; SO, Ho/AGP-2808-2022
OI So, Ho/0000-0001-7113-9390; Tam, Lai-Shan/0000-0001-6410-8852
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NR 100
TC 10
Z9 11
U1 3
U2 14
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1521-6942
EI 1521-1770
J9 BEST PRACT RES CL RH
JI Best Pract. Res. Clin. Rheumatol.
PD JUN
PY 2021
VL 35
IS 2
SI SI
AR 101689
DI 10.1016/j.berh.2021.101689
EA JUN 2021
PG 16
WC Rheumatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Rheumatology
GA SY3PC
UT WOS:000665802300008
PM 33965339
DA 2025-06-11
ER

PT J
AU Akbulut, FP
   Ikitimur, B
   Akan, A
AF Akbulut, Fatma Patlar
   Ikitimur, Baris
   Akan, Aydin
TI Wearable sensor-based evaluation of psychosocial stress in patients with
   metabolic syndrome
SO ARTIFICIAL INTELLIGENCE IN MEDICINE
LA English
DT Article
DE Wearable System; e-Health; HRV; Affective Computing; Neural Networks;
   Metabolic Syndrome
ID RECOGNITION; CLASSIFICATION
AB The prevalence of metabolic disorders has increased rapidly as such they become a major health issue recently. Despite the definition of genetic associations with obesity and cardiovascular diseases, they constitute only a small part of the incidence of disease. Environmental and physiological effects such as stress, behavioral and metabolic disturbances, infections, and nutritional deficiencies have now revealed as contributing factors to develop metabolic diseases. This study presents a multivariate methodology for the modeling of stress on metabolic syndrome (MES) patients. We have developed a supporting system to cope with MES patients' anxiety and stress by means of several biosignals such as ECG, GSR, body temperature, SpO(2), glucose level, and blood pressure that are measured by a wearable device. We employed a neural network model to classify emotions with HRV analysis in the detection of stressor moments. We have accurately recognized the stressful situations using physiological responses to stimuli by utilizing our proposed affective state detection algorithm. We evaluated our system with a dataset of 312 biosignal records from 30 participants and the results showed that our proposed method achieved an average accuracy of 92% and 89% in distinguishing stress level in MES and other groups respectively. Both being the focus of an MES group and others proved to be highly arousing experiences which were significantly reflected in the physiological signal. Exposure to the stress in MES and cardiovascular heart disease patients increases the chronic symptoms. An early stage of comprehensive intervention may reduce the risk of general cardiovascular events in these particular groups. In this context, the use of e-health applications such as our proposed system facilitates these processes.
C1 [Akbulut, Fatma Patlar] Istanbul Kultur Univ, Dept Comp Engn, Istanbul, Turkey.
   [Ikitimur, Baris] Istanbul Univ Cerrahpasa, Cerrahpasa Sch Med, Dept Cardiol, Istanbul, Turkey.
   [Akan, Aydin] Izmir Univ Econ, Dept Elect & Elect Engn, Izmir, Turkey.
C3 Istanbul Kultur University; Istanbul University - Cerrahpasa; Izmir
   Ekonomi Universitesi
RP Akbulut, FP (corresponding author), Istanbul Kultur Univ, Dept Comp Engn, Istanbul, Turkey.
EM f.patlar@iku.edu.tr; ikitimur@istanbul.edu.tr; akan.aydin@ieu.edu.tr
RI Akan, Aydin/P-3068-2019; Patlar Akbulut, Fatma/O-5520-2018; ikitimur,
   baris/O-1466-2013
OI Patlar Akbulut, Fatma/0000-0002-9689-7486; Akan,
   Aydin/0000-0001-8894-5794; ikitimur, baris/0000-0003-0602-1841
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NR 40
TC 40
Z9 41
U1 3
U2 31
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29a, 1043 NX AMSTERDAM, NETHERLANDS
SN 0933-3657
EI 1873-2860
J9 ARTIF INTELL MED
JI Artif. Intell. Med.
PD APR
PY 2020
VL 104
AR 101824
DI 10.1016/j.artmed.2020.101824
PG 11
WC Computer Science, Artificial Intelligence; Engineering, Biomedical;
   Medical Informatics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Computer Science; Engineering; Medical Informatics
GA LU5OP
UT WOS:000537804900017
PM 32499003
DA 2025-06-11
ER

PT J
AU Mustata, ML
   Neagoe, CD
   Radulescu, VM
   Dragne, IG
   Cîmpeanu, RC
   Radu, L
   Ahritculesei, RV
   Fortofoiu, D
   Predoi, MC
   Ianosi, SL
AF Mustata, Maria-Lorena
   Neagoe, Carmen-Daniela
   Radulescu, Virginia-Maria
   Dragne, Ioana-Gabriela
   Cimpeanu, Radu-Cristian
   Radu, Lucretiu
   Ahritculesei, Roxana-Viorela
   Fortofoiu, Dragos
   Predoi, Maria-Cristina
   Ianosi, Simona-Laura
TI Association Between Systemic Inflammation, Metabolic Syndrome and
   Quality of Life in Psoriasis Patients
SO LIFE-BASEL
LA English
DT Article
DE psoriasis; systemic inflammation; metabolic syndrome; DLQI; PASI; leptin
ID INDEX DLQI; DISEASE; PREVALENCE; DEPRESSION; EXPERIENCE; SEVERITY;
   ANXIETY; STRESS; BURDEN; PASI
AB Background/objectives: Psoriasis is a chronic inflammatory autoimmune disease with important systemic and psychosocial impacts. The association with metabolic syndrome (MS) impairs disease severity and negatively influences patient-reported outcomes, particularly their quality of life as measured by the Dermatology Life Quality Index (DLQI). This study aims to investigate the relationship between systemic inflammation, DLQI scores and disease severity, focusing on the persistent impact of MS on patient outcomes after one year of treatment. Methods: This retrospective cross-sectional study included 150 psoriasis patients, with 74 also meeting the diagnostic criteria for MS. Clinical and inflammatory markers such as systemic immune-inflammatory index (SII), cytokines (IL-17A, IL-23), leptin, BMI and triglycerides were analyzed alongside PASI and DLQI scores. Results: Patients with MS had significantly higher PASI and DLQI scores compared to those without MS, reflecting worse disease severity and quality of life (p < 0.01). Elevated SII levels were strongly associated with higher DLQI scores (p < 0.01). Despite considerable reductions in PASI scores over one year of treatment, DLQI scores indicated a persistent negative impact of MS on quality of life. Notably, markers of systemic inflammation, such as SII, leptin and cytokines, correlated positively with both PASI and DLQI scores, highlighting the role of systemic inflammation in disease burden. Conclusions: This study underlines the significant role of systemic inflammation and metabolic comorbidities in amplifying the burden of psoriasis. The persistent impact of MS on quality of life despite clinical improvement underscores the need for comprehensive treatment approaches targeting systemic inflammation, metabolic health and psychosocial factors to improve long-term outcomes.
C1 [Mustata, Maria-Lorena; Dragne, Ioana-Gabriela; Cimpeanu, Radu-Cristian; Ahritculesei, Roxana-Viorela; Fortofoiu, Dragos] Univ Med & Pharm Craiova, Doctoral Sch, Craiova 200349, Romania.
   [Neagoe, Carmen-Daniela] Univ Med & Pharm Craiova, Dept Internal Med, Fac Med, Craiova 200349, Romania.
   [Radulescu, Virginia-Maria] Univ Med & Pharm Craiova, Fac Med, Dept Med Informat & Biostat, Craiova 200349, Romania.
   [Radu, Lucretiu] Univ Med & Pharm Craiova, Fac Med, Dept Hyg, Craiova 200349, Romania.
   [Predoi, Maria-Cristina] Univ Med & Pharm Craiova, Fac Med, Dept Morphol, Craiova 200349, Romania.
   [Ianosi, Simona-Laura] Univ Med & Pharm Craiova, Fac Med, Dept Dermatol, Craiova 200349, Romania.
C3 University of Medicine & Pharmacy of Craiova; University of Medicine &
   Pharmacy of Craiova; University of Medicine & Pharmacy of Craiova;
   University of Medicine & Pharmacy of Craiova; University of Medicine &
   Pharmacy of Craiova; University of Medicine & Pharmacy of Craiova
RP Radulescu, VM (corresponding author), Univ Med & Pharm Craiova, Fac Med, Dept Med Informat & Biostat, Craiova 200349, Romania.
EM umlorena@yahoo.com; dananeagoe2014@gmail.com;
   virginia.radulescu@umfcv.ro; idragne@yahoo.com; cimpeanu_r@yahoo.com;
   lucretiu.radu@gmail.com; roxana.blendea@gmail.com;
   fortofoiudragos@gmail.com; predoi.cristina@yahoo.com;
   simonaianosi@hotmail.com
RI Cimpeanu, Radu/KII-6881-2024; Fortofoiu, Dragos/MIN-6701-2025; Ungureanu
   Mustata, Maria Lorena/LYS-6404-2024; Radulescu, Virginia
   Maria/HKE-1154-2023
OI Radulescu, Virginia Maria/0000-0001-9028-7583; Mustata,
   Maria-Lorena/0009-0008-6701-0760
FU University of Medicine and Pharmacy of Craiova, Romania
FX The Article Processing Charges were funded by the University of Medicine
   and Pharmacy of Craiova, Romania.
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NR 88
TC 1
Z9 1
U1 6
U2 6
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2075-1729
J9 LIFE-BASEL
JI Life-Basel
PD FEB
PY 2025
VL 15
IS 2
AR 212
DI 10.3390/life15020212
PG 22
WC Biology; Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics; Microbiology
GA Y3N2N
UT WOS:001431226700001
PM 40003621
OA gold
DA 2025-06-11
ER

PT J
AU Crepaldi, M
   Gianni, J
   Brugnera, A
   Greco, A
   Compare, A
   Rusconi, ML
   Poletti, B
   Omboni, S
   Tasca, GA
   Parati, G
AF Crepaldi, Maura
   Gianni, Jessica
   Brugnera, Agostino
   Greco, Andrea
   Compare, Angelo
   Rusconi, Maria Luisa
   Poletti, Barbara
   Omboni, Stefano
   Tasca, Giorgio Angelo
   Parati, Gianfranco
TI Predictors of Psychological Well-Being and Quality of Life in Patients
   with Hypertension: A Longitudinal Study
SO HEALTHCARE
LA English
DT Article
DE hypertension; metabolic syndrome; psychological well-being;
   health-related quality of life
ID EUROPEAN-SOCIETY; SELF-ESTEEM; CARDIOVASCULAR-DISEASE; BLOOD-PRESSURE;
   HEALTH SURVEY; ANXIETY; IMPACT; INDIVIDUALS; PREVALENCE; DEPRESSION
AB Previous research has highlighted the positive impact of greater health-related quality of life (Hr-QoL) and subjective well-being (SWB) on chronic diseases' severity and progression. There is a paucity of studies investigating the long-term trajectories of these variables among hypertensive patients. The present study aims to investigate the relationships between psychological variables (Type A and D personality, locus of control-LoC, self-esteem, and trait anxiety) with SWB and Hr-QoL in patients with hypertension and comorbid metabolic syndrome. A total of 185 volunteer patients (130 males, 70.3%; mean age 54 +/- 10.93) were enrolled. Patients filled out measures of Hr-QoL and SWB, LoC, and self-esteem at three time points-Type A and D behaviors and anxiety measures only at baseline. Analyses were run through two-level hierarchical mixed models with repeated measures (Level 1) nested within participants (Level 2), controlling for sociodemographic and clinical confounders. Neither Hr-QoL nor SWB changed over time. Patients with greater self-esteem and internal LoC (and lower external LoC) increased their SWB and Hr-QoL up to 1-year follow-up. A greater Type A behavior and trait anxiety at baseline predicted a longitudinal increase in most of the dependent variables. Results suggest that it could be useful to tailor interventions targeting specific variables to increase Hr-QoL and SWB among hypertensive patients.
C1 [Crepaldi, Maura; Gianni, Jessica; Brugnera, Agostino; Greco, Andrea; Compare, Angelo; Rusconi, Maria Luisa] Univ Bergamo, Dept Human & Social Sci, I-24129 Bergamo, Italy.
   [Poletti, Barbara] IRCCS Ist Auxol Italiano, Dept Neurol, Lab Neurosci, Piazzale Brescia 20, I-20149 Milan, Italy.
   [Poletti, Barbara] Univ Milan, Dept Oncol & Hemato Oncol, I-20122 Milan, Italy.
   [Omboni, Stefano] Italian Inst Telemed, Clin Res Unit, I-21048 Solbiate Arno, Italy.
   [Omboni, Stefano] Sechenov First Moscow State Med Univ, Dept Cardiol, Moscow 119435, Russia.
   [Tasca, Giorgio Angelo] Univ Ottawa, Sch Psychol, Ottawa, ON K1N 6N5, Canada.
   [Parati, Gianfranco] San Luca Hosp, IRCCS, Ist Auxol Italiano, Dept Cardiovasc Neural & Metab Sci, I-20149 Milan, Italy.
   [Parati, Gianfranco] Univ Milano Bicocca, Sch Med & Surg, I-20126 Milan, Italy.
C3 University of Bergamo; IRCCS Istituto Auxologico Italiano; University of
   Milan; Sechenov First Moscow State Medical University; University of
   Ottawa; IRCCS Istituto Auxologico Italiano; University of Milano-Bicocca
RP Crepaldi, M (corresponding author), Univ Bergamo, Dept Human & Social Sci, I-24129 Bergamo, Italy.
EM maura.crepaldi@guest.unibg.it; jessica.gianni@unibg.it;
   agostino.brugnera@unibg.it; andrea.greco@unibg.it;
   angelo.compare@unibg.it; marialuisa.rusconi@unibg.it;
   barbara.poletti@unimi.it; stefano.omboni@iitelemed.org;
   gtasca@uottawa.ca; gianfranco.parati@unimib.it
RI Crepaldi, Maura/IQW-0583-2023; Tasca, Giorgio/AAG-1867-2019; Poletti,
   Barbara/W-6917-2019; rusconi, maria luisa/G-2899-2017; Omboni,
   Stefano/D-1327-2015; Greco, Andrea/I-7266-2016; Parati,
   Gianfranco/K-7151-2016
OI rusconi, maria luisa/0000-0001-9958-1498; Tasca,
   Giorgio/0000-0001-7596-0661; Omboni, Stefano/0000-0002-7124-2096;
   Brugnera, Agostino/0000-0002-4066-4552; Greco,
   Andrea/0000-0002-8086-2801; Parati, Gianfranco/0000-0001-9402-7439;
   Gianni, Jessica/0009-0005-1742-3741; Crepaldi, Maura/0000-0001-7671-6679
FU Bracco S.p.A.; Ambrosio Antonietta, Ardito Maria Annunziata, Bernocchi
   Palmira
FX The authors would like to thank all the investigators of this study
   (listed in alphabetical order). Agabiti Rosei Enrico, Ambrosio
   Antonietta, Ardito Maria Annunziata, Bernocchi Palmira, Besostri
   Valeria, Bonso Elisa, Boresi Francesca, Cagnoni Francesca, Casciello
   Antonio, Cinelli Angelo, De Matteis Carmine, Del Frate Irene, Della Rosa
   Francesco, Destro Maurizio, Di Lillo Silvana, Dorigatti Francesca,
   Favale Stefano, Ferrari Viviana, Florio Antonia, Forleo Cinzia,
   Georgatos Joannhe, Gerunda Stefania, Ghiadoni Lorenzo, Grandi Anna
   Maria, Guarnieri Chiara, Guglielmi Michele, Guidi Antonella, Lonati
   Laura, Magagna Armando, Manfellotto Dario, Mare Micaela, Maria Maresca
   Andrea, Mongiardi Christian, Morani Giuliana, Muiesan Maria Lorenza,
   Omodeo Ombretta, Paini Anna, Palatini Paolo, Panunzio Mariligia,
   Pellicciotti Luisa, Quaglia Maria, Re Maria Antonietta, Rocchi Silvana,
   Rossi Ricci Alessandra, Scalvini Simonetta, Stassaldi Deborah, Taddei
   Stefano, Tosazzi Ellen, Venco Achille, Villa Giuseppe.
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NR 72
TC 1
Z9 1
U1 4
U2 6
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2227-9032
J9 HEALTHCARE-BASEL
JI Healthcare
PD MAR
PY 2024
VL 12
IS 6
AR 621
DI 10.3390/healthcare12060621
PG 13
WC Health Care Sciences & Services; Health Policy & Services
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services
GA MI4V1
UT WOS:001192989300001
PM 38540585
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Sadeghimahalli, F
   Karbaschi, R
   Zardooz, H
   Khodagholi, F
   Rostamkhani, F
AF Sadeghimahalli, Forouzan
   Karbaschi, Roxana
   Zardooz, Homeira
   Khodagholi, Fariba
   Rostamkhani, Fatemeh
TI Effect of early life stress on pancreatic isolated islets' insulin
   secretion in young adult male rats subjected to chronic stress
SO ENDOCRINE
LA English
DT Article
DE Early life stress; Young adulthood stress; GLUT2 level; HOMA-IR index;
   Corticosterone; Insulin secretion; Glucose tolerance; Adrenal glands
   weight
ID CHRONIC PSYCHOLOGICAL STRESS; CHRONIC PSYCHOSOCIAL STRESS; BETA-CELLS;
   MATERNAL SEPARATION; GLUCOSE-TRANSPORTER; METABOLIC SYNDROME; TRANSGENIC
   MICE; EXPRESSION; RESISTANCE; RESPONSES
AB Early stressful experiences may predispose organisms to certain disorders, including those of metabolic defects. This study aimed to explore the effects of early life stress on pancreatic insulin secretion and glucose transporter 2 (GLUT2) protein levels in stressed young adult male rats. Foot shock stress was induced in early life (at 2 weeks of age) and/or in young adulthood (at 8-10 weeks of age) for five consecutive days. Blood samples were taken before and after stress exposure in young adult rats. At the end of the experiment, glucose tolerance, isolated islets' insulin secretion, and pancreatic amounts of GLUT2 protein were measured. Our results show that early life stress has no effect on basal plasma corticosterone levels and adrenal weight, either alone or combined with young adulthood stress, but that early life + young adulthood stress could prevent weight gain, and cause an increase in basal plasma glucose and insulin. The homeostasis model assessment of insulin resistance index did not increase, when the rats were subjected to early life stress alone, but increased when combined with young adulthood stress. Moreover, glucose tolerance was impaired by the combination of early life ? young adult stress. There was a decrease in islet's insulin secretion in rats subjected to early life stress in response to 5.6 mM glucose concentration, but an increase with a concentration of 16.7 mM glucose. However, in rats subjected to early life + young adulthood stress, islet's insulin secretion increased in response to both the levels of glucose concentrations. GLUT2 protein levels decreased in response to early life stress and early life + young adulthood stress, but there was a greater decrease in the early life stress group. In conclusion, perhaps early life stress sensitizes the body to stressors later in life, making it more susceptible to metabolic syndrome only when the two are in combination.
C1 [Sadeghimahalli, Forouzan; Karbaschi, Roxana; Zardooz, Homeira] Shahid Beheshti Univ Med Sci, Fac Med, Dept Physiol, Tehran, Iran.
   [Karbaschi, Roxana] Shahid Beheshti Univ Med Sci, Fac Med, Neurosci Res Ctr, Tehran, Iran.
   [Zardooz, Homeira] Shahid Beheshti Univ Med Sci, Fac Med, Neurophysiol Res Ctr, Tehran, Iran.
   [Khodagholi, Fariba] Shahid Beheshti Univ Med Sci, Neurobiol Res Ctr, Tehran, Iran.
   [Khodagholi, Fariba] Shahid Beheshti Univ Med Sci, Neurosci Res Ctr, Tehran, Iran.
   [Rostamkhani, Fatemeh] Islamic Azad Univ, Dept Biol, Coll Basic Sci, Yadegar E Imam Khomeini RAH Branch, Tehran, Iran.
C3 Shahid Beheshti University Medical Sciences; Shahid Beheshti University
   Medical Sciences; Shahid Beheshti University Medical Sciences; Shahid
   Beheshti University Medical Sciences; Shahid Beheshti University Medical
   Sciences; Islamic Azad University
RP Zardooz, H (corresponding author), Shahid Beheshti Univ Med Sci, Fac Med, Neurophysiol Res Ctr, POB 19615-1178, Tehran, Iran.
EM homeira_zardooz@sbmu.ac.ir
RI zardooz, homeira/V-5293-2019; Khodagholi, Fariba/AAZ-4436-2020;
   Sadeghimahalli, Forouzan/AEX-3028-2022; karbaschi, roxana/N-4473-2017;
   Rostamkhani, Fatemeh/AAN-5034-2021
OI zardooz, homeira/0000-0001-8307-1848; karbaschi,
   roxana/0000-0003-4588-4252; Khodagholi, Fariba/0000-0002-4911-4530
FU Faculty of Medicine, Shahid Beheshti University of Medical Sciences
FX This work was supported by a Grant from Research Deputy of Faculty of
   Medicine, Shahid Beheshti University of Medical Sciences.
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NR 58
TC 16
Z9 18
U1 0
U2 11
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1355-008X
EI 1559-0100
J9 ENDOCRINE
JI Endocrine
PD MAR
PY 2015
VL 48
IS 2
BP 493
EP 503
DI 10.1007/s12020-014-0337-4
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA CD0IR
UT WOS:000350755000020
PM 25030548
DA 2025-06-11
ER

PT J
AU Li, JM
   He, XW
   Yang, Y
   Li, M
   Xu, CK
   Yu, R
AF Li, Jianmei
   He, Xiwei
   Yang, Yang
   Li, Mei
   Xu, Chenke
   Yu, Rong
TI Risk assessment of silica nanoparticles on liver injury in metabolic
   syndrome mice induced by fructose
SO SCIENCE OF THE TOTAL ENVIRONMENT
LA English
DT Article
DE Silica nanopartides; Metabolic syndrome; Hepatotoxicity; Oxidative
   stress; DNA damage
ID OXIDATIVE STRESS; NONALCOHOLIC STEATOHEPATITIS; SIO2 NANOPARTICLES;
   INSULIN-RESISTANCE; EISENIA FETIDA; DRUG-DELIVERY; IN-VITRO; CELLS;
   FIBROSIS; CYTOTOXICITY
AB This study aims to assess the effects and the mechanisms of silica nanoparticles (SiNPs) on hepatotoxicity in both normal and metabolic syndrome mouse models induced by fructose. Here, we found that SiNPs exposure lead to improved insulin resistance in metabolic syndrome mice, but markedly worsened hepatic ballooning, inflammation infiltration, and fibrosis. Moreover, SiNPs exposure aggravated liver injury in metabolic syndrome mice by causing serious DNA damage. Following SiNPs exposure, liver superoxide dismutase and catalase activities in metabolic syndrome mice were stimulated, which is accompanied by significantly increased malondialdehyde and 8-hydroxy-2-deoxyguanosine levels as compared to normal mice. Scanning electron microscope (SEM) revealed that SiNPs were more readily deposited in the liver mitochondria of metabolic syndrome mice, resulting in more severe mitochondrial injury as compared to normal mice. We speculated that SiNPs-induced mitochondrial injury might be the cause of hepatic oxidative stress, which further lead to a series of liver lesions as observed in mice following SiNPs exposure. Based on these results, it is likely that SiNPs will increase the risk and severity of liver disease in individuals with metabolic syndrome. Therefore, SiNPs should be used cautiously in food additives and clinical settings. (C) 2018 Elsevier B.V. All rights reserved.
C1 [Li, Jianmei; Yu, Rong] Nanjing Univ, Sch Life Sci, State Key Lab Pharmaceut Biotechnol, Nanjing 210023, Jiangsu, Peoples R China.
   [He, Xiwei; Yang, Yang; Li, Mei; Xu, Chenke] Nanjing Univ, Sch Environm, State Key Lab Pollut Control & Resource Reuse, Nanjing 210023, Jiangsu, Peoples R China.
C3 Nanjing University; Nanjing University
RP Li, M (corresponding author), 163 Xianlin Rd, Nanjing 210023, Jiangsu, Peoples R China.
EM meili@nju.edu.cn
OI Tekile, Ararso Beshea/0009-0005-4990-7118
FU National Natural Science Foundation of China [41773115, 41571468];
   Science and Technology Support Program of Jiangsu Province [BE2016172]
FX This research was supported by the National Natural Science Foundation
   of China (No. 41773115, 41571468), Science and Technology Support
   Program of Jiangsu Province (No. BE2016172).
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NR 58
TC 25
Z9 25
U1 1
U2 55
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0048-9697
EI 1879-1026
J9 SCI TOTAL ENVIRON
JI Sci. Total Environ.
PD JUL 1
PY 2018
VL 628-629
BP 366
EP 374
DI 10.1016/j.scitotenv.2018.02.047
PG 9
WC Environmental Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology
GA GG1QP
UT WOS:000432462000040
PM 29448021
DA 2025-06-11
ER

PT J
AU Hitsumoto, T
   Shirai, K
AF Hitsumoto, Takashi
   Shirai, Kohji
TI Factors affecting high-sensitivity cardiac troponin T elevation in
   Japanese metabolic syndrome patients
SO DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
LA English
DT Article
DE troponin; metabolic syndrome; risk factor; oxidative stress;
   cardio-ankle vascular index
AB Purpose: The blood concentration of cardiac troponin T (ie, high-sensitivity cardiac troponin T [hs-cTnT]), measured using a highly sensitive assay, represents a useful biomarker for evaluating the pathogenesis of heart failure or predicting cardiovascular events. However, little is known about the clinical significance of hs-cTnT in metabolic syndrome. The aim of this study was to examine the factors affecting hs-cTnT elevation in Japanese metabolic syndrome patients.
   Patients and methods: We enrolled 258 metabolic syndrome patients who were middle-aged males without a history of cardiovascular events. We examined relationships between hs-cTnT and various clinical parameters, including diagnostic parameters of metabolic syndrome.
   Results: There were no significant correlations between hs-cTnT and diagnostic parameters of metabolic syndrome. However, hs-cTnT was significantly correlated with age (P<0.01 ), blood concentrations of brain natriuretic peptide (P<0.01), reactive oxygen metabolites (markers of oxidative stress, P<0.001), and the cardio-ankle vascular index (marker of arterial function, P<0.01). Furthermore, multiple regression analysis revealed that these factors were independent variables for hs-cTnT as a subordinate factor.
   Conclusion: The findings of this study indicate that in vivo oxidative stress and abnormality of arterial function are closely associated with an increase in hs-cTnT concentrations in Japanese metabolic syndrome patients.
C1 [Hitsumoto, Takashi] Hitsumoto Med Clin, 2-7-7 Takezakicyou, Shimonoseki, Yamaguchi 7500025, Japan.
   [Shirai, Kohji] Toho Univ, Sch Med, Dept Vasc Funct Donated, Sakura Hosp, Chiba, Japan.
C3 Toho University
RP Hitsumoto, T (corresponding author), Hitsumoto Med Clin, 2-7-7 Takezakicyou, Shimonoseki, Yamaguchi 7500025, Japan.
EM thitsu@jcom.home.ne.jp
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NR 42
TC 9
Z9 9
U1 0
U2 1
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-7007
J9 DIABET METAB SYND OB
JI Diabetes Metab. Syndr. Obes.
PY 2015
VL 8
BP 157
EP 162
DI 10.2147/DMSO.S80907
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA V06QL
UT WOS:000213954600019
PM 25792848
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Charton, A
   Lacoste-Badie, R
   Tuffet, S
   Rousseau, A
   Maheu, E
   Fautrel, B
   Dougados, M
   Berenbaum, F
   Courties, A
   Sellam, J
AF Charton, Alix
   Lacoste-Badie, Romane
   Tuffet, Sophie
   Rousseau, Alexandra
   Maheu, Emmanuel
   Fautrel, Bruno
   Dougados, Maxime
   Berenbaum, Francis
   Courties, Alice
   Sellam, Jeremie
TI Metabolic syndrome is associated with more pain in hand osteoarthritis:
   Results from the DIGICOD cohort
SO OSTEOARTHRITIS AND CARTILAGE OPEN
LA English
DT Article
DE Metabolic syndrome; Hand osteoarthritis; Pain; Patient-reported outcomes
ID KNEE OSTEOARTHRITIS; INFLAMMATION; POPULATION; DISABILITY; FEATURES;
   OBESITY; STRESS; IMPACT; WOMEN; HIP
AB Background: The role of metabolic syndrome (MetS) in osteoarthritis (OA) pain, particularly in non-weight- bearing joints like the hand (HOA), remains debated. This study assessed whether MetS is linked to increased hand pain in patients with HOA. Methods: Using the DIGICOD cohort, 352 HOA patients (85 % women, mean age 66.4 f 7.4 years) were analyzed. Pain levels were evaluated via visual analog scale (VAS), AUSCAN pain subscore, and AIMS2 pain subscore. The presence of MetS (Adult Treatment Panel III criteria) and its components were assessed alongside demographic and clinical characteristics, including BMI and radiological severity (KL sum score). Associations were adjusted for confounders (age, sex, KL score, and HAD scale). Outcomes were dichotomized into high/low pain levels, with results expressed as odds ratios (OR) and 95 % confidence intervals (CI). Results: MetS was present in 36 % of patients and associated with higher pain levels during activity (VAS OR =1.61, 95 % CI 1.02-2.57) and overall OA pain (AIMS2 OR = 1.85, 95% CI 1.14-2.99). Adjusted AUSCAN pain subscore also correlated with MetS (OR = 1.66, 95 % CI 1.05-2.62), but significance was reduced when adjusting for HAD (OR = 1.56, 95 % CI 0.98-2.48). Elevated triglycerides, a MetS component, were significantly linked to higher AIMS2 pain scores (OR = 2.58, 95% CI 1.09-6.07). BMI was not found to be independently associated with pain. Conclusion: MetS correlates with increased pain in HOA, independent of structural damage and anxiety/depression, underscoring its systemic impact on OA-related pain.
C1 [Charton, Alix; Maheu, Emmanuel; Berenbaum, Francis; Courties, Alice; Sellam, Jeremie] Sorbonne Univ, St Antoine Hosp, APHP, Rheumatol Dept, Paris, France.
   [Lacoste-Badie, Romane; Tuffet, Sophie; Rousseau, Alexandra] Sorbonne Univ, Clin Pharmacol Dept, AP HP, Paris, France.
   [Lacoste-Badie, Romane; Tuffet, Sophie; Rousseau, Alexandra] St Antoine Hosp, Clin Res Platform Eastern Paris URCEST, CRB, CRC, Paris, France.
   [Fautrel, Bruno] Sorbonne Univ, La Pitie Salpetriere Hosp, AP HP, Rheumatol Dept, Paris, France.
   [Dougados, Maxime] Univ Paris, Cochin Hosp, Rheumatol Dept, AP HP, Paris, France.
   [Berenbaum, Francis; Courties, Alice; Sellam, Jeremie] Ctr Rech St Antoine CRSA, INSERM, UMRS 938, Paris, France.
C3 Assistance Publique Hopitaux Paris (APHP); Sorbonne Universite; Hopital
   Universitaire Saint-Antoine - APHP; Sorbonne Universite; Assistance
   Publique Hopitaux Paris (APHP); Assistance Publique Hopitaux Paris
   (APHP); Sorbonne Universite; Hopital Universitaire Saint-Antoine - APHP;
   Universite Paris Cite; Sorbonne Universite; Assistance Publique Hopitaux
   Paris (APHP); Hopital Universitaire Pitie-Salpetriere - APHP; Assistance
   Publique Hopitaux Paris (APHP); Universite Paris Cite; Hopital
   Universitaire Cochin - APHP; Institut National de la Sante et de la
   Recherche Medicale (Inserm); Sorbonne Universite
RP Sellam, J (corresponding author), St Antoine Hosp, Rheumatol Dept, 184 rue Faubourg St Antoine, F-75012 Paris, France.
EM Jeremie.sellam@aphp.fr
RI Dougados, Maxime/P-5287-2016; Berenbaum, Francis/AAO-5690-2020
OI ROUSSEAU, Alexandra/0000-0002-9935-185X
FU French Society of Rheumatology; TRB Chemedica
FX Role of the funding source DIGICOD cohort is labeled and granted by the
   French Society of Rheumatology. DIGICOD cohort was supported by an
   unrestricted grant from TRB Chemedica, who did not take part in the
   study design, collection, analysis, and interpretation of data, writing
   of the report or the decision to submit the article for publication.
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NR 36
TC 2
Z9 2
U1 0
U2 0
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
EI 2665-9131
J9 OSTEOARTHR CARTIL OP
JI Osteoarthr. Cartil. Open
PD MAR
PY 2025
VL 7
IS 1
AR 100573
DI 10.1016/j.ocarto.2025.100573
EA FEB 2025
PG 7
WC Orthopedics; Rheumatology
WE Emerging Sources Citation Index (ESCI)
SC Orthopedics; Rheumatology
GA X6Y3T
UT WOS:001426775500001
PM 40026905
OA Green Accepted, gold
DA 2025-06-11
ER

PT J
AU Aucoin, M
   LaChance, L
   Cooley, K
   Kidd, S
AF Aucoin, Monique
   LaChance, Laura
   Cooley, Kieran
   Kidd, Sean
TI Diet and Psychosis: A Scoping Review
SO NEUROPSYCHOBIOLOGY
LA English
DT Review
DE Dietary constituents; Nutritional guidelines; Mental health;
   Schizophrenia spectrum disorders
ID POLYUNSATURATED FATTY-ACIDS; CARDIOMETABOLIC RISK; MAJOR DEPRESSION;
   DOUBLE-BLIND; SCHIZOPHRENIA; METAANALYSIS; SYMPTOMS; INTERVENTIONS;
   PREVALENCE; NUTRITION
AB Introduction: Schizophrenia spectrum disorders (SSD) represent a cluster of severe mental illnesses. Diet has been identified as a modifiable risk factor and opportunity for intervention in many physical illnesses and more recently in mental illnesses such as unipolar depression; however, no dietary guidelines exist for patients with SSD. Objective: This review sought to systematically scope the existing literature in order to identify nutritional interventions for the prevention or treatment of mental health symptoms in SSD as well as gaps and opportunities for further research. Methods: This review followed established methodological approaches for scoping reviews including an extensive a priori search strategy and duplicate screening. Because of the large volume of results, an online program (Abstrackr) was used for screening and tagging. Data were extracted based on the dietary constituents and analyzed. Results: Of 55,330 results identified by the search, 822 studies met the criteria for inclusion. Observational evidence shows a connection between the presence of psychotic disorders and poorer quality dietary patterns, higher intake of refined carbohydrates and total fat, and lower intake or levels of fibre, omega-3 and omega-6 fatty acids, vegetables, fruit, and certain vitamins and minerals (vitamin B-12 and B-6, folate, vitamin C, zinc, and selenium). Evidence illustrates a role of food allergy and sensitivity as well as microbiome composition and specific phytonutrients (such as L-theanine, sulforaphane, and resveratrol). Experimental studies have demonstrated benefit using healthy diet patterns and specific vitamins and minerals (vitamin B-12 and B-6, folate, and zinc) and amino acids (serine, lysine, glycine, and tryptophan). Discussion: Overall, these findings were consistent with many other bodies of knowledge about healthy dietary patterns. Many limitations exist related to the design of the individual studies and the ability to extrapolate the results of studies using dietary supplements to dietary interventions (food). Dietary recommendations are presented as well as recommendations for further research including more prospective observational studies and intervention studies that modify diet constituents or entire dietary patterns with statistical power to detect mental health outcomes.
C1 [Aucoin, Monique; Cooley, Kieran] Canadian Coll Naturopath Med, 1255 Sheppard Ave East, Toronto, ON M2K 1E2, Canada.
   [LaChance, Laura; Kidd, Sean] Ctr Addict & Mental Hlth, 250 Coll St,7th Floor, Toronto, ON M5T 1R8, Canada.
   [LaChance, Laura] Univ Toronto, Toronto, ON, Canada.
   [Cooley, Kieran] Univ Technol, Australian Res Ctr Complementary & Integrat Med, Sydney, NSW, Australia.
C3 University of Toronto; Centre for Addiction & Mental Health - Canada;
   University of Toronto; University of Technology Sydney
RP Aucoin, M (corresponding author), Canadian Coll Naturopath Med, 1255 Sheppard Ave East, Toronto, ON M2K 1E2, Canada.; LaChance, L (corresponding author), Ctr Addict & Mental Hlth, 250 Coll St,7th Floor, Toronto, ON M5T 1R8, Canada.
EM maucoin@ccnm.edu; Laura.Lachance@camh.ca
RI Cooley, Kieran/L-3080-2019; Aucoin, Monique/KHX-8889-2024
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NR 104
TC 74
Z9 75
U1 2
U2 39
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0302-282X
EI 1423-0224
J9 NEUROPSYCHOBIOLOGY
JI Neuropsychobiology
PD JAN
PY 2020
VL 79
IS 1
BP 20
EP 42
DI 10.1159/000493399
PG 23
WC Neurosciences; Psychiatry; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry; Psychology
GA KH8AO
UT WOS:000510871600003
PM 30359969
OA Bronze
DA 2025-06-11
ER

PT J
AU Corey, SM
   Epel, E
   Schembri, M
   Pawlowsky, SB
   Cole, RJ
   Araneta, MRG
   Barrett-Connor, E
   Kanaya, AM
AF Corey, Sarah M.
   Epel, Elissa
   Schembri, Michael
   Pawlowsky, Sarah B.
   Cole, Roger J.
   Araneta, Maria Rosario G.
   Barrett-Connor, Elizabeth
   Kanaya, Alka M.
TI Effect of restorative yoga vs. stretching on diurnal cortisol dynamics
   and psychosocial outcomes in individuals with the metabolic syndrome:
   The PRYSMS randomized controlled trial
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE Stress; Metabolic syndrome; Waking cortisol; Diurnal cortisol;
   Dexamethasone; Social support
ID HEAD-DOWN TILT; SALIVARY CORTISOL; SOCIAL SUPPORT; BLOOD-PRESSURE;
   CHRONIC STRESS; RISK-FACTORS; OBESITY; MEN; INFLAMMATION; DEPRESSION
AB Purpose: Chronic stimulation and dysregulation of the neuroendocrine system by stress may cause metabolic abnormalities. We estimated how much cortisol and psychosocial outcomes improved with a restorative yoga (relaxation) versus a low impact stretching intervention for individuals with the metabolic syndrome.
   Methods: We conducted a 1-year multi-center randomized controlled trial (6-month intervention and 6-month maintenance phase) of restorative yoga vs. stretching. Participants completed surveys to assess depression, social support, positive affect, and stress at baseline, 6 months and 12 months. For each assessment, we collected saliva at four points daily for three days and collected response to dexamethasone on the fourth day for analysis of diurnal cortisol dynamics. We analyzed our data using multivariate regression models, controlling for study site, medications (antidepressants, hormone therapy), body mass index, and baseline cortisol values.
   Results: Psychosocial outcome measures were available for 171 study participants at baseline, 140 at 6 months, and 132 at 1 year. Complete cortisol data were available for 136 of 171 study participants (72 in restorative yoga and 64 in stretching) and were only available at baseline and 6 months. At 6 months, the stretching group had decreased cortisol at waking and bedtime compared to the restorative yoga group. The pattern of changes in stress mirrored this improvement, with the stretching group showing reductions in chronic stress severity and perseverative thoughts about their stress. Perceived stress decreased by 1.5 points (-0.4; 3.3, p = 0.11) at 6 months, and by 2.0 points (0.1; 3.9, p = 0.04) at 1 year in the stretching compared to restorative yoga groups. Post hoc analyses suggest that in the stretching group only, perceived increases in social support (particularly feelings of belonging), but not changes in stress were related to improved cortisol dynamics.
   Conclusions: We found significant decreases in salivary cortisol, chronic stress severity, and stress perception in the stretching group compared to the restorative yoga group. Group support during the interactive stretch classes may have contributed to these changes. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Corey, Sarah M.; Epel, Elissa; Schembri, Michael; Kanaya, Alka M.] Univ Calif San Francisco, San Francisco, CA 94115 USA.
   [Pawlowsky, Sarah B.] San Francisco State Univ, San Francisco, CA 94132 USA.
   [Cole, Roger J.] Synchrony Appl Hlth Sci, Del Mar, CA 92014 USA.
   [Araneta, Maria Rosario G.; Barrett-Connor, Elizabeth] Univ Calif San Diego, San Diego, CA 92093 USA.
C3 University of California System; University of California San Francisco;
   California State University System; San Francisco State University;
   University of California System; University of California San Diego
RP Corey, SM (corresponding author), UCSF Osher Ctr Integrat Med, 1545 Divisadero St, San Francisco, CA 94115 USA.
EM sarahmcorey@yahoo.com
RI Epel, Elissa/ABI-6703-2022
OI , Roger/0000-0002-5765-4035
FU NIH National Center for Complementary and Alternative Medicine
   [5R01AT004569-02]; NIH/NCRR UCSF-CTSI [UL1 RR024131]; National Center
   for Complementary and Integrative Health [T32AT003997] Funding Source:
   NIH RePORTER; National Heart Lung and Blood Institute [K24HL112827]
   Funding Source: NIH RePORTER
FX The PRYSMS study was funded by the NIH National Center for Complementary
   and Alternative Medicine grant number 5R01AT004569-02. Clinical visits
   at UCSF for this project were also supported by NIH/NCRR UCSF-CTSI grant
   number UL1 RR024131 and by the Cliff Lede Family Foundation. Its
   contents are solely the responsibility of the authors and do not
   necessarily represent the official views of the NIH.
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NR 64
TC 25
Z9 29
U1 0
U2 38
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
EI 1873-3360
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD NOV
PY 2014
VL 49
BP 260
EP 271
DI 10.1016/j.psyneuen.2014.07.012
PG 12
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA AR1KA
UT WOS:000343342900026
PM 25127084
OA Green Published, Green Accepted
DA 2025-06-11
ER

PT J
AU Quansah, DY
   Gross, J
   Gilbert, L
   Pauchet, A
   Horsch, A
   Benhalima, K
   Cosson, E
   Puder, JJ
AF Quansah, Dan Yedu
   Gross, Justine
   Gilbert, Leah
   Pauchet, Amelie
   Horsch, Antje
   Benhalima, Katrien
   Cosson, Emmanuel
   Puder, Jardena J.
TI Cardiometabolic and Mental Health in Women With Early Gestational
   Diabetes Mellitus: A Prospective Cohort Study
SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Article
DE GDM risk factors; cardiometabolic; early gestational diabetes; metabolic
   syndrome; postpartum; mental health
ID INTERNATIONAL ASSOCIATION; PERINATAL OUTCOMES; PREGNANCY OUTCOMES;
   HYPERGLYCEMIA; DIAGNOSIS; CRITERIA
AB Context Early diagnosis and treatment of gestational diabetes (GDM) may reduce adverse obstetric and neonatal outcomes, especially in high-risk women. However, there is a lack of data for other outcomes. Objective We compared cardiometabolic and mental health outcomes in women with early (eGDM) and classical (cGDM) GDM. Methods This prospective cohort included 1185 All women with cGDM and 76 women with eGDM. The eGDM group had GDM risk factors (BMI >30 kg/m(2), family history of diabetes, history of GDM, ethnicity), were tested at <20 weeks gestational age, and diagnosed using American Diabetes Association prediabetes criteria. All women underwent lifestyle adaptations. Obstetric, neonatal, mental, and cardiometabolic outcomes were assessed during pregnancy and postpartum. Results The eGDM group had lower gestational weight gain than cGDM (10.7 +/- 6.2 vs 12.6 +/- 6.4; P = 0.03) but needed more medical treatment (66% vs 42%; P < 0.001). They had similar rates of adverse maternal and neonatal outcomes, except for increased large-for-gestational-age infants (25% vs 15%; P = 0.02). Mental health during pregnancy and postpartum did not differ between groups. eGDM had more atherogenic postpartum lipid profile than cGDM (P <= 0.001). In eGDM, the postpartum prevalence of the metabolic syndrome (MetS) was 1.8-fold, prediabetes was 3.1-fold, and diabetes was 7.4-fold higher than cGDM (waist circumference-based MetS: 62% vs 34%/BMI-based MetS: 46% vs 24%; prediabetes: 47.5% vs 15.3%; diabetes: 11.9% vs 1.6%, all P < 0.001). These differences remained unchanged after adjusting for GDM risk factors. Conclusion Compared with cGDM, eGDM was not associated with differences in mental health, but with increased adverse cardiometabolic outcomes, independent of GDM risk factors and gestational weight gain. This hints to a preexisting risk profile in eGDM.
C1 [Quansah, Dan Yedu; Gilbert, Leah; Puder, Jardena J.] Lausanne Univ Hosp, Dept Woman Mother Child, Obstet Serv, Rue Bugnon 21, CH-1011 Lausanne, Switzerland.
   [Gross, Justine; Pauchet, Amelie] Lausanne Univ Hosp, Dept Med, Serv Endocrinol Diabet & Metab, CH-1011 Lausanne, Switzerland.
   [Horsch, Antje] Univ Lausanne, Inst Higher Educ & Res Healthcare IUFRS, CH-1010 Lausanne, Switzerland.
   [Horsch, Antje] Lausanne Univ Hosp, Dept Woman Mother Child, Neonatol Serv, CH-1011 Lausanne, Switzerland.
   [Benhalima, Katrien] Katholieke Univ Leuven, Dept Endocrinol, UZ Gasthuisberg, B-3000 Leuven, Belgium.
   [Cosson, Emmanuel] Paris 13 Univ, Avicenne Hosp, AP HP,CRNH IdF, Sorbonne Paris Cite,CINFO,Dept Endocrinol Diabeto, Bobigny, France.
   [Cosson, Emmanuel] Univ Paris 13, Sorbonne Paris Cite, INSERM, UMR U1153,U1125,Inra,Cnam, Bobigny, France.
C3 University of Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV);
   University of Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV);
   University of Lausanne; University of Lausanne; Centre Hospitalier
   Universitaire Vaudois (CHUV); KU Leuven; University Hospital Leuven;
   Assistance Publique Hopitaux Paris (APHP); Hopital Universitaire
   Avicenne - APHP; Institut National de la Sante et de la Recherche
   Medicale (Inserm); Universite Paris 13; INRAE; Universite Paris Cite
RP Quansah, DY (corresponding author), Lausanne Univ Hosp, Dept Woman Mother Child, Obstet Serv, Rue Bugnon 21, CH-1011 Lausanne, Switzerland.
EM dan.quansah@chuv.ch
RI Gilbert, Leah/AAX-7055-2020; Cosson, Emmanuel/F-3051-2017; Benhalima,
   Katrien/K-5800-2017; Quansah, Dan/B-8499-2018; Horsch,
   Antje/AEQ-2835-2022
OI Cosson, Emmanuel/0000-0002-8785-3385; Benhalima,
   Katrien/0000-0002-3325-0263; Quansah, Dan/0000-0002-3091-9400; Horsch,
   Antje/0000-0002-9950-9661; Gilbert, Leah/0000-0002-0580-0141; Puder,
   Jardena/0000-0002-0460-7614
FU Swiss National Science Foundation [SNF 32003B_176119]; Novo Nordisk
FX This study is a pilot of a project grant by the Swiss National Science
   Foundation (SNF 32003B_176119). The cohort database received an
   unrestricted educational grant from Novo Nordisk. The SNF and Novo
   Nordisk had no role regarding the content of the original data or
   analyses or in the drafting of this manuscript.
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NR 52
TC 12
Z9 12
U1 0
U2 7
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0021-972X
EI 1945-7197
J9 J CLIN ENDOCR METAB
JI J. Clin. Endocrinol. Metab.
PD FEB 17
PY 2022
VL 107
IS 3
BP E996
EP E1008
DI 10.1210/clinem/dgab791
EA NOV 2021
PG 13
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism
GA ZB5RA
UT WOS:000756897900032
PM 34718650
OA Bronze, Green Published, Green Accepted
DA 2025-06-11
ER

PT J
AU Walders-Abramson, N
   Nadeau, KJ
   Kelsey, MM
   Schmiege, SJ
   Ellert, S
   Cejka, A
   Bhatnagar, K
   Zeitler, P
AF Walders-Abramson, Natalie
   Nadeau, Kristen J.
   Kelsey, Megan M.
   Schmiege, Sarah J.
   Ellert, Swan
   Cejka, Anna
   Bhatnagar, Kelly
   Zeitler, Phil
TI Psychological Functioning in Adolescents with Obesity Co-Morbidities
SO CHILDHOOD OBESITY
LA English
DT Article
ID QUALITY-OF-LIFE; NUTRITION EXAMINATION SURVEY; 3RD NATIONAL-HEALTH;
   METABOLIC SYNDROME; DEPRESSIVE SYMPTOMS; CARDIOVASCULAR RISK;
   PREVALENCE; STRENGTHS; CHILDREN
AB Background: An understanding of the relationships among obesity severity, medical co-morbidities, and psychological complications is important in the design of interventions to encourage overweight youth and families to accomplish healthy lifestyle changes.
   Methods: We evaluated associations among psychological status, diagnosed medical co-morbidities consistent with components of the metabolic syndrome, and BMI among 166 obese adolescents (11-18 years) referred for endocrinology consultation. We hypothesized that there would be higher levels of psychological distress among youth with more diagnosed components of the metabolic syndrome (i.e., more medical co-morbidities associated with obesity).
   Results: Contrary to expectation, we found that meeting criteria for extreme obesity alone was more predictive of psychological difficulties.
   Conclusions: The degree of obesity may be more relevant than the number of associated medical co-morbidities in impacting psychological health. It is important to recognize individual differences between patients in terms of identifying motivating goals for accomplishing weight management.
C1 [Walders-Abramson, Natalie] Univ Colorado Denver, Dept Psychiat & Behav Sci, Aurora, CO 80045 USA.
   [Walders-Abramson, Natalie; Nadeau, Kristen J.; Kelsey, Megan M.; Zeitler, Phil] Univ Colorado Denver, Div Endocrinol, Dept Pediat, Aurora, CO 80045 USA.
   Childrens Hosp Colorado, Aurora, CO USA.
   [Schmiege, Sarah J.] Univ Colorado Denver, Dept Biostat & Informat, Colorado Sch Publ Hlth, Aurora, CO 80045 USA.
   [Ellert, Swan] Univ Colorado Denver, Colorado Clin & Translat Sci Inst, Aurora, CO 80045 USA.
   [Cejka, Anna] Univ Colorado Denver, Dept Psychol, Aurora, CO 80045 USA.
   [Bhatnagar, Kelly] Cleveland Ctr Eating Disorders, Cleveland, OH USA.
C3 Children's Hospital Colorado; University of Colorado System; University
   of Colorado Anschutz Medical Campus; Children's Hospital Colorado;
   University of Colorado System; University of Colorado Anschutz Medical
   Campus; Children's Hospital Colorado; Colorado School of Public Health;
   University of Colorado System; University of Colorado Anschutz Medical
   Campus; Children's Hospital Colorado; University of Colorado System;
   University of Colorado Anschutz Medical Campus; Children's Hospital
   Colorado; University of Colorado System; University of Colorado Anschutz
   Medical Campus; Children's Hospital Colorado
RP Walders-Abramson, N (corresponding author), Univ Colorado Denver, Childrens Hosp Colorado, Dept Psychiat, 13123 E 16th Ave,A036-B130, Aurora, CO 80045 USA.
EM Natalie.abramson@childrenscolorado.org
OI Ellert, Swan/0000-0001-5284-7674; Schmiege, Sarah/0000-0003-0729-6556;
   Zeitler, Philip/0000-0001-5756-7858; Kelsey, Megan/0000-0002-0755-1951
FU Eagle Riders of the Fraternal Order of Eagles Aerie [3324]; National
   Institutes of Health/National Center for Advancing Translational
   Sciences (NIH/NCATS) Colorado CTSI [UL1 TR000154]
FX This research was supported by the Eagle Riders of the Fraternal Order
   of Eagles Aerie #3324. This research was also supported, in part, by
   National Institutes of Health/National Center for Advancing
   Translational Sciences (NIH/NCATS) Colorado CTSI Grant Number UL1
   TR000154. Contents are the authors' sole responsibility and do not
   necessarily represent official NIH views.
CR Anderson BJ, 2011, DIABETES CARE, V34, P2205, DOI 10.2337/dc11-0431
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NR 27
TC 13
Z9 18
U1 0
U2 8
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 2153-2168
EI 2153-2176
J9 CHILD OBES
JI Child Obes.
PD AUG
PY 2013
VL 9
IS 4
BP 319
EP 325
DI 10.1089/chi.2012.0120
PG 7
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Pediatrics
GA AI4PI
UT WOS:000336846900007
PM 23763659
OA Green Published
DA 2025-06-11
ER

PT J
AU Chirinos, DA
   Medina-Lezama, J
   Salinas-Najarro, B
   Arguelles, W
   Llabre, MM
   Schneiderman, N
   Paz-Manrique, R
   Bolanos, JF
   Khan, Z
   Chirinos, JA
AF Chirinos, Diana A.
   Medina-Lezama, Josefina
   Salinas-Najarro, Belissa
   Arguelles, William
   Llabre, Maria M.
   Schneiderman, Neil
   Paz-Manrique, Roberto
   Bolanos, Juan F.
   Khan, Zubair
   Chirinos, Julio A.
TI Depressive symptoms and carotid intima-media thickness in South American
   Hispanics: results from the PREVENCION study
SO JOURNAL OF BEHAVIORAL MEDICINE
LA English
DT Article
DE Depression; Carotid intima-media thickness; Gender moderation; South
   American Hispanics; Cardiovascular disease
ID C-REACTIVE PROTEIN; CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME;
   MYOCARDIAL-INFARCTION; RISK-FACTORS; YOUNG-ADULTS; ANXIETY;
   ATHEROSCLEROSIS; INFLAMMATION; PREVENTION
AB This study aimed to: (1) examine the relationship between depressive symptoms and subclinical atherosclerosis, measured by carotid intima-media thickness (IMT); and, (2) Determine the moderating effect of gender in this relationship among South American Hispanics. We studied 496 adults enrolled in the population-based PREVENCION study. Carotid IMT was measured with high-resolution ultrasonography. Depressive symptoms were assessed using the Hospital Anxiety and Depression Scale. Mean carotid IMT was 0.66 mm. (SD = 0.17) and mean depression score was 5.6 (SD = 3.5). Depressive symptoms were not associated with carotid IMT (beta = 0.04, p = 0.222) in multivariate analyses. A significant moderating effect of gender was found (beta for interaction = 0.10, p = 0.030), resulting from a significant association between depressive symptoms and carotid IMT in men but not women. Depressive symptoms were associated with subclinical atherosclerosis in South American Hispanic men but not women after controlling for demographic characteristics and traditional cardiovascular risk factors.
C1 [Chirinos, Diana A.; Arguelles, William; Llabre, Maria M.; Schneiderman, Neil] Univ Miami, Dept Psychol, Coral Gables, FL 33124 USA.
   [Chirinos, Diana A.; Medina-Lezama, Josefina; Salinas-Najarro, Belissa; Paz-Manrique, Roberto; Bolanos, Juan F.] Santa Maria Catholic Univ, Res Inst, Arequipa, Peru.
   [Khan, Zubair; Chirinos, Julio A.] Univ Penn, Philadelphia, PA 19104 USA.
   [Chirinos, Julio A.] Philadelphia VA Med Ctr, Philadelphia, PA USA.
C3 University of Miami; Universidad Catolica de Santa Maria; University of
   Pennsylvania; University of Pennsylvania; Pennsylvania Medicine; US
   Department of Veterans Affairs; Veterans Health Administration (VHA);
   Philadelphia Veterans Affairs Medical Center
RP Chirinos, DA (corresponding author), Univ Miami, Dept Psychol, POB 248185, Coral Gables, FL 33124 USA.
EM dchirinos-medina@psy.miami.edu
RI Paz-Manrique, Roberto/LTD-4556-2024; Chirinos, Julio/HNR-7642-2023
OI Khan, Zubair/0000-0002-0451-9155; Paz-Manrique,
   Roberto/0000-0002-2802-8545
FU Santa Maria Research Institute in Arequipa, Peru
FX The PREVENCION study was supported by the Santa Maria Research Institute
   in Arequipa, Peru.
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NR 60
TC 8
Z9 8
U1 0
U2 7
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0160-7715
EI 1573-3521
J9 J BEHAV MED
JI J. Behav. Med.
PD APR
PY 2015
VL 38
IS 2
BP 284
EP 293
DI 10.1007/s10865-014-9599-9
PG 10
WC Psychology, Clinical
WE Social Science Citation Index (SSCI)
SC Psychology
GA CD5NV
UT WOS:000351135900010
PM 25267357
DA 2025-06-11
ER

PT J
AU Sorlí, JV
   de la Cámara, E
   Fernández-Carrión, R
   Asensio, EM
   Portolés, O
   Ortega-Azorín, C
   Pérez-Fidalgo, A
   Villamil, LV
   Fitó, M
   Barragán, R
   Coltell, O
   Corella, D
AF Sorli, Jose V.
   de la Camara, Edurne
   Fernandez-Carrion, Rebeca
   Asensio, Eva M.
   Portoles, Olga
   Ortega-Azorin, Carolina
   Perez-Fidalgo, Alejandro
   Villamil, Laura V.
   Fito, Montserrat
   Barragan, Rocio
   Coltell, Oscar
   Corella, Dolores
TI Depression and Accelerated Aging: The Eveningness Chronotype and Low
   Adherence to the Mediterranean Diet Are Associated with Depressive
   Symptoms in Older Subjects
SO NUTRIENTS
LA English
DT Article
DE nutrition; aging; mediterranean diet; chronotype; mental health; chronic
   diseases; depression; methylation clocks
ID MORNINGNESS-EVENINGNESS; CIRCADIAN-RHYTHMS; MAJOR DEPRESSION; SLEEP
   QUALITY; AGE; CONTRIBUTE; INPATIENTS; DISEASE; BURDEN; GENDER
AB Background and objectives: Depression often results in premature aging, which increases the risk of other chronic diseases, but very few studies have analyzed the association between epigenetic biomarkers of aging and depressive symptoms. Similarly, limited research has examined the joint effects of adherence to the Mediterranean diet (MedDiet) and chronotype on depressive symptoms, accounting for sex differences. Therefore, these are the objectives of our investigation in a Mediterranean population at high cardiovascular risk. Methods: We analyzed 465 older subjects (aged 55-75) with metabolic syndrome and assessed depressive symptoms by the Beck Depression Inventory (BDI-II). MedDiet adherence was measured with the 17-item MedDiet score, and chronotype with the Morningness-Eveningness Questionnaire (MEQ). Blood DNA methylation was analyzed, and epigenomic biomarkers of age acceleration were determined. We focused on the Dunedin Pace of Aging Computed from the Epigenome (DunedinPACE). We fitted multivariable models with interaction terms. Results: Prevalence of depression was statistically higher in women (p < 0.001). MedDiet adherence was strongly and inversely associated with depressive symptoms in the whole population (p < 0.01), while the MEQ score was inversely associated (p < 0.05). In the joint analysis, both MedDiet adherence and chronotype remained statistically associated with the BDI-II score (p < 0.05), showing additive effects. No interaction effects were observed. In women, a higher score in depressive symptoms was significantly associated with faster age acceleration (measured with the DunedinPACE biomarker). This association remained significant even after adjustment for MedDiet adherence and chronotype. Conclusions: In older subjects with metabolic syndrome, the eveningness chronotype was associated with greater depressive symptoms, but a higher adherence to the MedDiet could potentially counteract the chronotype risk with additive effects. Women showed stronger associations, and importantly, we reported for the first time in this population that depressive symptoms were associated with accelerated aging.
C1 [Sorli, Jose V.; de la Camara, Edurne; Fernandez-Carrion, Rebeca; Asensio, Eva M.; Portoles, Olga; Ortega-Azorin, Carolina; Villamil, Laura V.; Barragan, Rocio; Corella, Dolores] Univ Valencia, Sch Med, Dept Prevent Med & Publ Hlth, Valencia 46010, Spain.
   [Sorli, Jose V.; Fernandez-Carrion, Rebeca; Asensio, Eva M.; Portoles, Olga; Ortega-Azorin, Carolina; Fito, Montserrat; Barragan, Rocio; Coltell, Oscar; Corella, Dolores] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr, Madrid 28029, Spain.
   [de la Camara, Edurne] Hosp Clin Univ Lozano Blesa, Serv Oftalmol, Zaragoza 50009, Spain.
   [Perez-Fidalgo, Alejandro] Univ Clin Hosp Valencia, Dept Med Oncol, Valencia 46010, Spain.
   [Perez-Fidalgo, Alejandro] Hlth Inst Carlos III, Biomed Res Networking Ctr Canc CIBERONC, Madrid 28029, Spain.
   [Perez-Fidalgo, Alejandro] INCLIVA Biomed Res Inst, Valencia 46010, Spain.
   [Villamil, Laura V.] Univ Antonio Narino, Sch Med, Dept Physiol, Bogota 111511, Colombia.
   [Fito, Montserrat] Hosp del Mar Med Res Inst IMIM, Cardiovasc Risk & Nutr Res Grp, Barcelona 08003, Spain.
   [Coltell, Oscar] Univ Jaume 1, Dept Comp Languages & Syst, Castellon de La Plana 12071, Spain.
C3 University of Valencia; CIBER - Centro de Investigacion Biomedica en
   Red; CIBEROBN; Instituto de Salud Carlos III; Lozano Blesa University
   Clinical Hospital; Universidad Antonio Narino; Hospital del Mar Research
   Institute; Hospital del Mar; Universitat Jaume I
RP Corella, D (corresponding author), Univ Valencia, Sch Med, Dept Prevent Med & Publ Hlth, Valencia 46010, Spain.; Corella, D (corresponding author), Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr, Madrid 28029, Spain.
EM jose.sorli@uv.es; oscar.coltell@uji.es; dolores.corella@uv.es
RI Sorlí, José/L-8758-2014; Coltell, Oscar/AAA-9936-2019; Reparaz,
   Olga/AAB-3243-2019; Perez-Fidalgo, Alejandro/P-2944-2014; Fito Colomer,
   Montse/C-1822-2012; Coltell, Oscar/L-8549-2014; Corella,
   Dolores/L-9888-2014
OI Asensio, Eva Maria/0000-0003-4558-0988; Fito Colomer,
   Montse/0000-0002-1817-483X; Coltell, Oscar/0000-0002-4518-8495; Sorli,
   Jose V/0000-0002-0130-2006; Fernandez Carrion,
   Rebeca/0000-0001-7738-5111; Corella, Dolores/0000-0002-2366-4104;
   Barragan-Arnal, Rocio/0000-0001-8072-3791; CAROLINA,
   ORTEGA-AZORIN/0000-0001-6719-9358
FU Spanish Ministry of Health (Instituto de SaludCarlos III); Ministerio de
   Economia y Competitividad-Fondo Europeo de Desarrollo Regional(FEDER)
   [CIBER 06/03, SAF2016-80532-R, PI19/00781]; Generalitat Valenciana
   [PROMETEO2017/017, PROMETEO/2021/021]; Programa Santiago Grisolia
   [CIGRIS/2022/082]; AEI [PID2019-108858RB-I00]; ERDF A way of making
   Europe; Ministerio de Ciencia, Innovacion y Universidades-AEI
   [PID2023-150110OB-I00];  [PI13/00728];  [PI16/00366]
FX This study was partially funded by the Spanish Ministry of Health
   (Instituto de SaludCarlos III) and the Ministerio de Economia y
   Competitividad-Fondo Europeo de Desarrollo Regional(FEDER) (grants CIBER
   06/03, SAF2016-80532-R, PI13/00728, PI16/00366 and PI19/00781); the
   Generalitat Valenciana (grants PROMETEO2017/017, PROMETEO/2021/021;
   Programa Santiago Grisolia no CIGRIS/2022/082); grant
   PID2019-108858RB-I00 funded by AEI 10.13039/501100011033 and by "ERDF A
   way of making Europe", and the Ministerio de Ciencia, Innovacion y
   Universidades-AEI (grant PID2023-150110OB-I00).
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NR 95
TC 1
Z9 1
U1 2
U2 2
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JAN
PY 2025
VL 17
IS 1
AR 104
DI 10.3390/nu17010104
PG 20
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA S0G0P
UT WOS:001395107000001
PM 39796538
OA gold
DA 2025-06-11
ER

PT J
AU Laight, DW
   Carrier, MJ
   Änggård, EE
AF Laight, DW
   Carrier, MJ
   Änggård, EE
TI Antioxidants, diabetes and endothelial dysfunction
SO CARDIOVASCULAR RESEARCH
LA English
DT Review
DE blood flow; diabetes; endothelial function; free radicals; nitric oxide
ID RENIN-ANGIOTENSIN SYSTEM; MUSCLE BLOOD-FLOW; OBESE ZUCKER RAT;
   CONVERTING ENZYME-INHIBITION; INSULIN-RESISTANCE SYNDROME;
   CORONARY-ARTERY DISEASE; NITRIC-OXIDE RELEASE; CARDIOVASCULAR-DISEASE;
   SKELETAL-MUSCLE; OXIDATIVE STRESS
AB While a damaged endothelium is recognised to be a key accessory to diabetic macroangiopathy, awareness is developing that impairments concerning endothelium- and nitric oxide (NO)-dependent microvascular function, may contribute to several other corollaries of diabetes, such as hypertension, dyslipidaemia and in vivo insulin resistance. There are now several reports describing elevations in specific oxidant stress markers in both insulin resistance syndrome (IRS) and diabetes, together with determinations of reduced total antioxidant defence and depletions in individual antioxidants. Such a pro-oxidant environment in diabetes may disrupt endothelial function through the inactivation of NO, resulting in the attenuation of a fundamental anti-atherogenic and euglycaemic vascular influence. Indeed, experimental and clinical data suggest that the supplementation of insulin resistant or diabetic states with antioxidants such as vitamin E, normalises oxidant stress and improves both endothelium-dependent vasodilation and insulin sensitivity. However, the promising potential efficacy of antioxidant therapy in cardiovascular disease and diabetes, in either a primary or secondary preventative role, awaits definitive clinical demonstration. (C) 2000 Elsevier Science B.V. All rights reserved.
C1 St Bartholomews & Royal london Sch Med & Dent, William Harvey Res Inst, London EC1 6BQ, England.
C3 University of London; Queen Mary University London
RP Laight, DW (corresponding author), St Bartholomews & Royal london Sch Med & Dent, William Harvey Res Inst, Charterhouse Sq, London EC1 6BQ, England.
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NR 121
TC 196
Z9 218
U1 1
U2 6
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0008-6363
J9 CARDIOVASC RES
JI Cardiovasc. Res.
PD AUG
PY 2000
VL 47
IS 3
BP 457
EP 464
DI 10.1016/S0008-6363(00)00054-7
PG 8
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 349QE
UT WOS:000089056500007
PM 10963719
OA Bronze
DA 2025-06-11
ER

PT J
AU Gawlik-Kotelnicka, O
   Strzelecki, D
AF Gawlik-Kotelnicka, Oliwia
   Strzelecki, Dominik
TI Probiotics as a Treatment for "Metabolic Depression"? A Rationale for
   Future Studies
SO PHARMACEUTICALS
LA English
DT Review
DE depression; obesity; metabolic syndrome; probiotics; microbiota
ID FATTY LIVER-DISEASE; POSTMYOCARDIAL INFARCTION DEPRESSION; FECAL
   MICROBIOTA TRANSPLANTATION; LACTOBACILLUS-HELVETICUS R0052;
   BIFIDOBACTERIUM-LONGUM R0175; OBESE POSTMENOPAUSAL WOMEN; BODY-MASS
   INDEX; OXIDATIVE STRESS; GUT MICROBIOTA; DOUBLE-BLIND
AB Depression and metabolic diseases often coexist, having several features in common, e.g., chronic low-grade inflammation and intestinal dysbiosis. Different microbiota interventions have been proposed to be used as a treatment for these disorders. In the paper, we review the efficacy of probiotics in depressive disorders, obesity, metabolic syndrome and its liver equivalent based on the published experimental studies, clinical trials and meta-analyses. Probiotics seem to be effective in reducing depressive symptoms when administered in addition to antidepressants. Additionally, probiotics intake may ameliorate some of the clinical components of metabolic diseases. However, standardized methodology regarding probiotics use in clinical trials has not been established yet. In this narrative review, we discuss current knowledge on the recently used methodology with its strengths and limitations and propose criteria that may be implemented to create a new study of the effectiveness of probiotics in depressive disorders comorbid with metabolic abnormalities. We put across our choice on type of study population, probiotics genus, strains, dosages and formulations, intervention period, as well as primary and secondary outcome measures.
C1 [Gawlik-Kotelnicka, Oliwia; Strzelecki, Dominik] Med Univ Lodz, Dept Affect & Psychot Disorders, PL-90419 Lodz, Poland.
C3 Medical University Lodz
RP Gawlik-Kotelnicka, O (corresponding author), Med Univ Lodz, Dept Affect & Psychot Disorders, PL-90419 Lodz, Poland.
EM oliwia.gawlik@umed.lodz.pl; dominik.strzelecki@umed.lodz.pl
RI Gawlik-Kotelnicka, Oliwia/ITU-7979-2023; Strzelecki,
   Dominik/S-9340-2016; Gawlik-Kotelnicka, Oliwia/S-9936-2016
OI Gawlik-Kotelnicka, Oliwia/0000-0003-1398-3117; Strzelecki,
   Dominik/0000-0002-8559-1078
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NR 174
TC 15
Z9 15
U1 4
U2 38
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1424-8247
J9 PHARMACEUTICALS-BASE
JI Pharmaceuticals
PD APR
PY 2021
VL 14
IS 4
AR 384
DI 10.3390/ph14040384
PG 19
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA RR9TP
UT WOS:000643431600001
PM 33924064
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU On, YK
   Park, R
   Hyon, MS
   Kim, SK
   Kwon, YJ
AF On, YK
   Park, R
   Hyon, MS
   Kim, SK
   Kwon, YJ
TI Are low total serum antioxidant status and elevated levels of C-reactive
   protein and monocyte chemotactic protein-1 associated with cardiac
   syndrome X?
SO CIRCULATION JOURNAL
LA English
DT Article
DE cardiac syndrome X; C-reactive protein; cytokine; oxidative stress
ID NORMAL CORONARY ARTERIOGRAMS; CHEST-PAIN; RENOVASCULAR HYPERTENSION;
   MICROVASCULAR ANGINA; OXIDATIVE STRESS; ARTERY-DISEASE
AB Background Cardiac syndrome X, also known as microvascular angina, is characterized by exercise-induced chest pain occurring despite a normal coronary angiogram. Several causes and mechanisms have been proposed to explain both the chest pain and ST segment depression. In this study, the association, if any, between cardiac syndrome X and several factors, including blood total antioxidant status, C-reactive protein (CRP), and monocyte chemotactic protein-1 (MCP-1) levels, was investigated.
   Methods and Results The study group comprised 36 patients who had been diagnosed as cardiac syndrome X on the basis of a positive treadmill test and a normal coronary angiogram, and 24 control patients. Total serum antioxidant status and CRP were assessed, and the levels of P-selectin, MCP-1, and interleukins 6 and 10 were also measured. Total serum antioxidant levels were determined to be significantly lower in the cardiac syndrome X patients than in the controls. CRP and serum MCP-1 levels, however, were found to be significantly higher in the cardiac syndrome X group. The total serum antioxidant levels and serum MCP-1 levels were comparable with the levels observed in a group of chronic stable angina patients.
   Conclusions In the present study, patients who had been diagnosed as cardiac syndrome X demonstrated increased systemic oxidative and enhanced inflammatory status.
C1 Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Cardiac & Vasc Ctr,Dept Med,Div Cardiol, Seoul 135710, South Korea.
   Soonchunhyang Univ Hosp, Dept Internal Med, Seoul, South Korea.
C3 Sungkyunkwan University (SKKU); Samsung Medical Center; Soonchunhyang
   University; Soonchunhyang University Hospital
RP Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Cardiac & Vasc Ctr,Dept Med,Div Cardiol, 50 Ilwon Dong, Seoul 135710, South Korea.
EM ykon@skku.edu
RI Kim, Jong/AAE-8556-2019
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NR 20
TC 22
Z9 22
U1 0
U2 2
PU JAPANESE CIRCULATION SOC
PI TOYKO
PA 18TH FLOOR IMPERIAL HOTEL TOWER, 1-1-1 UCHISAIWAI-CHO CHIYODA-KU, TOYKO,
   100-0011, JAPAN
SN 1346-9843
EI 1347-4820
J9 CIRC J
JI Circ. J.
PD OCT
PY 2005
VL 69
IS 10
BP 1212
EP 1217
DI 10.1253/circj.69.1212
PG 6
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 967ZZ
UT WOS:000232131800011
PM 16195619
OA Bronze
DA 2025-06-11
ER

PT J
AU Yao, F
   Jiang, DD
   Guo, WH
   Guo, LS
   Gao, MM
   Bai, Y
   Wang, X
   Zhang, LS
AF Yao, F.
   Jiang, D-D
   Guo, W-H
   Guo, L-S
   Gao, M-M
   Bai, Y.
   Wang, X.
   Zhang, L-S
TI FABP4 inhibitor attenuates inflammation and endoplasmic reticulum stress
   of islet in leptin receptor knockout rats
SO EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
LA English
DT Article
DE Endoplasmic reticulum (ER) stress; Fatty acid binding protein 4 (FABP4);
   Islet; Leptin receptor knockout (Leer(-/-)) rat; Metabolic syndrome
ID BINDING PROTEIN 4; ADIPOKINE; FAT
AB OBJECTIVE: Metabolic syndrome is characterized by abdominal obesity, hypertriglyceridemia and hyperglycemia. Fatty acid binding protein 4 (FABP4), as a member of intracellular lipid chaperones, is not only engaged in lipid transport but involved in inflammation and insulin resistance. The present study was to investigate the effects of BMS309403. a specific FABP4 inhibitor, on metabolic syndrome and its possible molecular mechanisms in islets.
   MATERIALS AND METHODS: Leptin receptor knockout (Lepr(-/-)) rat. a novel and representative animal model of metabolic syndrome, was adopted in this study. Lepr(-/-). male rats and their wild littermates were grouped and intragastrically administered with BMS309403. Glucose Tolerance Test (GTT) and Insulin Tolerance Test (ITT) were performed on all rats. Serum insulin was detected by ELISA. The metabolic characters, as well as liver and kidney functions, were evaluated by serum biochemical assay. Immunohistochemistry and Western blot were adopted to detect the expression levels of FABP4, CD68, GRP78, ATF6, p-IRE1a. and Cleaved caspase-3.
   RESULTS: Lepr(-/-) rats showed prominent characteristics of metabolic syndrome with increased FABP4, inflammatory infiltration, ER stress and apoptosis in islets. BMS309403 administration attenuated inflammation, ER stress and apoptosis in Lepr(-/-). rat islets while stimulating insulin secretion as well as improving manifestation of metabolic syndrome without hepatic and renal toxicity.
   CONCLUSIONS: FABP4 increased in Lepr(-/-) islets and might be involved in the regulation of islet inflammation and apoptosis via ER stress. FABP4 inhibitor BMS309403 could ameliorate islet inflammation and apoptosis in metabolic syndrome through suppressing ER stress.
C1 [Yao, F.; Jiang, D-D; Bai, Y.; Zhang, L-S] Hebei Med Univ, Dept Pathol, Shijiazhuang, Hebei, Peoples R China.
   [Guo, W-H; Zhang, L-S] Hebei Key Lab Environm & Human Hlth, Shijiazhuang, Hebei, Peoples R China.
   [Guo, L-S] Hebei Med Univ, Dept Med Phys, Shijiazhuang, Hebei, Peoples R China.
   [Gao, M-M] Hebei Med Univ, Inst Basic Med, Lab Lipid Metab, Shijiazhuang, Hebei, Peoples R China.
   [Wang, X.] Hebei Med Univ, Affiliated Hosp 3, Dept Endocrinol, Shijiazhuang, Hebei, Peoples R China.
C3 Hebei Medical University; Hebei Medical University; Hebei Medical
   University; Hebei Medical University
RP Zhang, LS (corresponding author), Hebei Med Univ, Dept Pathol, Shijiazhuang, Hebei, Peoples R China.; Zhang, LS (corresponding author), Hebei Key Lab Environm & Human Hlth, Shijiazhuang, Hebei, Peoples R China.
EM lianshanzhang@hebmu.edu.cn
RI Guo, Weiheng/E-4701-2013
OI Guo, Weiheng/0000-0001-5668-0613
FU Key Research and Development Projects of Hebei Provincial Department of
   Science and Technology [18274801D]; Major projection of Hebei Provincial
   Department of Education [ZD2016010]
FX This study was supported by Key Research and Development Projects of
   Hebei Provincial Department of Science and Technology (18274801D) and
   Major projection of Hebei Provincial Department of Education
   (ZD2016010).
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NR 25
TC 19
Z9 24
U1 1
U2 7
PU VERDUCI PUBLISHER
PI ROME
PA VIA GREGORIO VII, ROME, 186-00165, ITALY
SN 1128-3602
J9 EUR REV MED PHARMACO
JI Eur. Rev. Med. Pharmacol. Sci.
PY 2020
VL 24
IS 24
BP 12808
EP 12820
DI 10.26355/eurrev_202012_24182
PG 13
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA PI8WO
UT WOS:000601364400043
PM 33378030
DA 2025-06-11
ER

PT J
AU Vogelzangs, N
   Beekman, ATF
   Dortland, AKBV
   Schoevers, RA
   Giltay, EJ
   de Jonge, P
   Penninx, BWJH
AF Vogelzangs, Nicole
   Beekman, Aartjan T. F.
   Dortland, Arianne K. B. van Reedt
   Schoevers, Robert A.
   Giltay, Erik J.
   de Jonge, Peter
   Penninx, Brenda W. J. H.
TI Inflammatory and Metabolic Dysregulation and the 2-Year Course of
   Depressive Disorders in Antidepressant Users
SO NEUROPSYCHOPHARMACOLOGY
LA English
DT Article
DE inflammation; metabolic syndrome; depression; antidepressants;
   prospective cohort
ID TREATMENT-RESISTANT DEPRESSION; FACTOR ANTAGONIST INFLIXIMAB; C-REACTIVE
   PROTEIN; GENERAL-POPULATION; TREATMENT RESPONSE; MAJOR DEPRESSION;
   ANXIETY NESDA; METAANALYSIS; CYTOKINES; NETHERLANDS
AB Scarce evidence suggests that inflammatory and metabolic dysregulation predicts poor response to antidepressants, which could result in worse depression outcome. This study prospectively examined whether inflammatory and metabolic dysregulation predicted the 2-year course of depressive disorders among antidepressant users. Data were from the Netherlands Study of Depression and Anxiety, including 315 persons (18-65 years) with a current depressive disorder (major depressive disorder, dysthymia) at baseline according to the DSM-IV criteria and using antidepressants. Inflammatory (C-reactive protein, interleukin-6 (IL-6), tumor-necrosis factor-a) and metabolic (waist circumference, triglycerides, high-density lipoprotein (HDL) cholesterol, blood pressure, fasting glucose) factors were measured at baseline. Primary outcome for course of depression was indicated by whether or not a DSM-IV depressive disorder diagnosis was still/ again present at 2-year follow-up, indicating chronicity of depression. Elevated IL-6, low HDL cholesterol, hypertriglyceridemia, and hyperglycemia were associated with chronicity of depression in antidepressant users. Persons showing 4 inflammatory or metabolic dysregulations had a 1.90 increased odds of depression chronicity (95% Cl = 1.12-3.23). Among persons who recently (ie, at most 3 months) started antidepressant medication (N= 103), having >= 4 dysregulations was associated with a 6.85 increased odds of depression chronicity (95% Cl = 1.95-24.06). In conclusion, inflammatory and metabolic dysregulations were found to predict a more chronic course of depressive disorders among patients using antidepressants. This could suggest that inflammatory and metabolic dysregulation worsens depression course owing to reduced antidepressant treatment response and that alternative intervention treatments may be needed for depressed persons with inflammatory and metabolic dysregulation.
C1 [Vogelzangs, Nicole; Beekman, Aartjan T. F.; Dortland, Arianne K. B. van Reedt; Penninx, Brenda W. J. H.] Vrije Univ Amsterdam, Med Ctr, Dept Psychiat, NL-1081 HL Amsterdam, Netherlands.
   [Vogelzangs, Nicole; Beekman, Aartjan T. F.; Dortland, Arianne K. B. van Reedt; Penninx, Brenda W. J. H.] Vrije Univ Amsterdam, Med Ctr, EMGO Inst Hlth & Care Res, NL-1081 HL Amsterdam, Netherlands.
   [Vogelzangs, Nicole; Penninx, Brenda W. J. H.] Vrije Univ Amsterdam, Med Ctr, NL-1081 HL Amsterdam, Netherlands.
   [Schoevers, Robert A.; de Jonge, Peter] Univ Groningen, Univ Med Ctr Groningen, Dept Psychiat, Groningen, Netherlands.
   [Giltay, Erik J.] Leiden Univ, Med Ctr, Dept Psychiat, Leiden, Netherlands.
C3 Vrije Universiteit Amsterdam; Vrije Universiteit Amsterdam; Vrije
   Universiteit Amsterdam; University of Groningen; Leiden University;
   Leiden University Medical Center (LUMC); Leiden University - Excl LUMC
RP Vogelzangs, N (corresponding author), Vrije Univ Amsterdam, Med Ctr, Dept Psychiat, AJ Emststr 1187, NL-1081 HL Amsterdam, Netherlands.
EM n.vogelzangs@vumc.nl
RI Giltay, Erik/AAL-9948-2021; Beekman, Aartjan T./LUZ-6919-2024; Penninx,
   Brenda/S-7627-2017; de Jonge, Peter/L-6395-2013
OI de Jonge, Peter/0000-0002-0866-6929; Schoevers, Robert
   A/0000-0003-0760-9866; Giltay, Erik J./0000-0001-8874-2292
FU Geestkracht program of the Netherlands Organization for Health Research
   and Development (Zon-Mw) [10-000-1002]; Netherlands Institute for Health
   Services Research (NIVEL); Netherlands Institute of Mental Health and
   Addiction (Trimbos); EMGO Institute for Health and Care Research; VICI
   [91811602]; PdJ through a VICI [91812607]; Neuroscience Campus Amsterdam
FX The infrastructure for the NESDA study (http://www. nesda.nl) is funded
   through the Geestkracht program of the Netherlands Organization for
   Health Research and Development (Zon-Mw, Grant No. 10-000-1002) and is
   supported by participating universities and mental healthcare
   organizations (VU University Medical Center, GGZ inGeest, Arkin, Leiden
   University Medical Center, GGZ Rivierduinen, University Medical Center
   Groningen, Lentis, GGZ Friesland, GGZ Drenthe, Institute for Quality of
   Health Care (IQ Healthcare), Netherlands Institute for Health Services
   Research (NIVEL), and Netherlands Institute of Mental Health and
   Addiction (Trimbos). NV was supported through a fellowship from the EMGO
   Institute for Health and Care Research, BP through a VICI grant (NWO
   Grant No. 91811602) and PdJ through a VICI grant (NWO Grant No.
   91812607). Assaying of inflammatory markers was supported by the
   Neuroscience Campus Amsterdam. ATFB received grants for research from
   Eli Lilly, Astra Zenica, Janssen, and Shire and as a speaker from
   Lundbeck and Eli Lilly. All other authors declare no conflict of
   interest.
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NR 50
TC 109
Z9 119
U1 0
U2 17
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0893-133X
EI 1740-634X
J9 NEUROPSYCHOPHARMACOL
JI Neuropsychopharmacology
PD JUN
PY 2014
VL 39
IS 7
BP 1624
EP 1634
DI 10.1038/npp.2014.9
PG 11
WC Neurosciences; Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA AH4OG
UT WOS:000336107300008
PM 24442097
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Cicek, MA
   Tuygar Okutucu, F
   Ozturk, N
AF Cicek, Mehmet Ali
   Okutucu, Fatma Tuygar
   Ozturk, Nurinnisa
TI Irisin, adropin, and preptin as biomarkers of energy dysregulation in
   depressive disorder
SO CURRENT MEDICAL RESEARCH AND OPINION
LA English
DT Article
DE Depression; depression subtypes; irisin; adropin; preptin
ID ENDOTHELIAL FUNCTION; METABOLIC SYNDROME; BDNF; ANXIETY; BRAIN
AB Objective: Lack of energy, fatigue, debility are often seen in depression and hardly respond to treatment. Finding some biomarkers for these symptoms may be important for diagnosis and treatment. We aimed to investigate the possible relationship between depression and energy-related molecules irisin, adropin and preptin.
   Methods: There were 117 patients with depression and 59 healthy volunteers included in the study. Sociodemographic characteristics and clinical features of groups were evaluated, and depressed patients were divided into subtypes, then irisin, adropin, preptin levels were compared between depressive patients and healthy controls and between subtypes. Depression severity, quality of life, functionality and the relations with irisin, adropin and preptin levels and associations between depression subtypes were evaluated.
   Results: Irisin, adropin, and preptin levels were lower in depression, positively correlated with quality of life, and negatively correlated with depression severity and functional impairment. Depression subtypes showed no difference in irisin, adropin and preptin levels.
   Conclusions: We found decreased serum irisin, adropin and preptin levels in depression. Our results may support investigation of irisin, adropin and preptin as biomarkers for depression but it might be more meaningful to evaluate these biomarkers in a long-term follow-up.
C1 [Cicek, Mehmet Ali; Okutucu, Fatma Tuygar] Ataturk Univ, Dept Psychiat, Med Fac, Erzurum, Turkiye.
   [Ozturk, Nurinnisa] Ataturk Univ, Dept Biochem, Med Fac, Erzurum, Turkiye.
C3 Ataturk University; Ataturk University
RP Tuygar Okutucu, F (corresponding author), Ataturk Univ, Dept Psychiat, Med Fac, Erzurum, Turkiye.
EM fokutucu.tuygar@atauni.edu.tr
RI Ozturk, Nurinnisa/AAG-4580-2019; Tuygar Okutucu, Fatma/JDW-6478-2023;
   ÇİÇEK, MEHMET ALİ/HLQ-2909-2023
OI TUYGAR OKUTUCU, Fatma/0000-0001-7706-6751
FU Scientific Research Projects Unit of Ataturk University [TTU-2021-9504]
FX This study was supported by the Scientific Research Projects Unit of
   Ataturk University (TTU-2021-9504).
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NR 30
TC 6
Z9 6
U1 2
U2 10
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0300-7995
EI 1473-4877
J9 CURR MED RES OPIN
JI Curr. Med. Res. Opin.
PD SEP 2
PY 2023
VL 39
IS 9
BP 1263
EP 1270
DI 10.1080/03007995.2023.2247317
PG 8
WC Medicine, General & Internal; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Research & Experimental Medicine
GA EO3K9
UT WOS:001139826700001
PM 37574912
DA 2025-06-11
ER

PT J
AU Miller, GE
   Chen, E
   Armstrong, CC
   Carroll, AL
   Ozturk, S
   Rydland, KJ
   Brody, GH
   Parrish, TB
   Nusslock, R
AF Miller, Gregory E.
   Chen, Edith
   Armstrong, Casey C.
   Carroll, Ann L.
   Ozturk, Sekine
   Rydland, Kelsey J.
   Brody, Gene H.
   Parrish, Todd B.
   Nusslock, Robin
TI Functional connectivity in central executive network protects youth
   against cardiometabolic risks linked with neighborhood violenc
SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF
   AMERICA
LA English
DT Article
DE resilience; stress; children; neuroscience; cardiovascular
ID METABOLIC SYNDROME; SOCIOECONOMIC-STATUS; DEFAULT MODE; COMMUNITY
   VIOLENCE; BRAIN NETWORKS; HEALTH; CHILDREN; ADOLESCENTS; STRESS;
   CHILDHOOD
AB Although violent crime has declined in recent decades, it remains a recurring feature of daily life in some neighborhoods. Mounting evidence indicates that such violence has a long reach, which goes beyond family and friends of the victim and undermines the health of people in the surrounding community. However, like all forms of adversity, community violence elicits a heterogeneous response: Some remain healthy, but others deteriorate. Despite much scientific attention, the neural circuitries that contribute to differential adaptation remain poorly understood. Drawing on knowledge of the brain's intrinsic functional architecture, we predicted that individual differences in resting-state connectivity would explain variability in the strength of the association between neighborhood violence and cardiometabolic health. We enrolled 218 urban youth (age 12-14 years, 66% female; 65% black or Latino) and used geocoding to characterize their exposure to neighborhood murder over the past five years. Multiple aspects of cardiometabolic health were assessed, including obesity, insulin resistance, and metabolic syndrome. Functional MRI was used to quantify the connectivity of major intrinsic networks. Consistent with predictions, resting-state connectivity within the central executive network (CEN) emerged as a moderator of adaptation. Across six distinct outcomes, a higher neighborhood murder rate was associated with greater cardiometabolic risk, but this relationship was apparent only among youth who displayed lower CEN resting-state connectivity. By contrast, there was little evidence of moderation by the anterior salience and default mode networks. These findings advance basic and applied knowledge about adaptation by highlighting intrinsic CEN connectivity as a potential neurobiological contributor to resilience.
C1 [Miller, Gregory E.; Chen, Edith; Nusslock, Robin] Northwestern Univ, Inst Policy Res, Evanston, IL 60208 USA.
   [Miller, Gregory E.; Chen, Edith; Armstrong, Casey C.; Carroll, Ann L.; Ozturk, Sekine; Nusslock, Robin] Northwestern Univ, Dept Physiol, Evanston, IL 60208 USA.
   [Rydland, Kelsey J.] Northwestern Univ, Res & Informat Serv, Evanston, IL 60208 USA.
   [Brody, Gene H.] Univ Georgia, Ctr Family Res, Athens, GA 30602 USA.
   [Parrish, Todd B.] Northwestern Feinberg Sch Med, Dept Radiol, Chicago, IL 60611 USA.
C3 Northwestern University; Northwestern University; Northwestern
   University; University System of Georgia; University of Georgia;
   Northwestern University; Feinberg School of Medicine
RP Miller, GE (corresponding author), Northwestern Univ, Inst Policy Res, Evanston, IL 60208 USA.; Miller, GE (corresponding author), Northwestern Univ, Dept Physiol, Evanston, IL 60208 USA.
EM greg.miller@northwestern.edu
OI Rydland, Kelsey/0000-0002-0340-4639; Miller,
   Gregory/0000-0002-7217-1082; Parrish, Todd/0000-0002-1184-1572;
   Nusslock, Robin/0000-0001-6283-7824
FU NIH [HL122328, DA027827, DC012283, MH100117]
FX The work was supported by NIH Grants HL122328, DA027827, DC012283, and
   MH100117.
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NR 46
TC 56
Z9 61
U1 1
U2 14
PU NATL ACAD SCIENCES
PI WASHINGTON
PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA
SN 0027-8424
J9 P NATL ACAD SCI USA
JI Proc. Natl. Acad. Sci. U. S. A.
PD NOV 20
PY 2018
VL 115
IS 47
BP 12063
EP 12068
DI 10.1073/pnas.1810067115
PG 6
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Science & Technology - Other Topics
GA HA9RH
UT WOS:000450642800064
PM 30397136
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Narita, K
   Murata, T
   Hamada, T
   Kosaka, H
   Sudo, S
   Mizukami, K
   Yoshida, H
   Wada, Y
AF Narita, Kosuke
   Murata, Tetsuhito
   Hamada, Toshihiko
   Kosaka, Hirotaka
   Sudo, Satoru
   Mizukami, Kimiko
   Yoshida, Haruyoshi
   Wada, Yuji
TI Associations between trait anxiety, insulin resistance, and
   atherosclerosis in the elderly: A pilot cross-sectional study
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE insulin resistance; anxiety; adiponectin; leptin; atherosclerosis;
   elderly subjects
ID INTIMA-MEDIA THICKNESS; CORONARY-HEART-DISEASE; ENDOTHELIAL FUNCTION;
   DEPRESSION; ARTERY; RISK; ADIPONECTIN; DYSFUNCTION; SYMPTOMS; STRESS
AB Anxiety has been shown to be associated with cardiovascular disease. Atherosclerosis is responsible for the vast majority of cardiovascular events. Recent evidence is accumulating to show that insulin resistance (IR) plays a central role in determining the clinical manifestations of established atherosclerotic lesions. The current preliminary study aimed to investigate the associations between trait anxiety, IR, and atherosclerotic progression in healthy elderly subjects with normal fasting glucose and without metabolic syndrome. Thirty-five healthy elderly subjects (19 males and 16 females, mean age 64.5 +/- 4.7 years) were enrolled in this study. Trait anxiety was measured using a questionnaire corresponding to the trait anxiety scale taken from the State and Trait Anxiety Inventory. The homeostasis model assessment (HOMA-R) and plasma leptin-to-adiponectin ratio (L/A ratio), which are convenient IR indexes calculated from fasting blood sampling, were examined. As measurements of atherosclerotic progression, we performed two ultrasound methods, namely brachial artery flow-mediated dilation (FMD), an endothelial function assessment quantitatively reflecting the endothelium-dependent vasodilation responses following hyperemia, and measurement of carotid intima-media thickness (IMT). The severity of trait anxiety was positively associated with HOMA-R and L/A ratio, and negatively associated with the percent change of brachial artery FMD (%FMD). HOMA-R and L/A ratio were positively associated with carotid IMT, and L/A ratio was negatively associated with %FMD. These data showed the associations between trait anxiety, IR indexes and endothelial dysfunction or atherosclerotic progression. This pilot study, with a cross-sectional design, supports the promising role of IR for clarifying the pathophysiological mechanism by which anxiety contributes to an increasing risk of atherosclerosis. (C) 2007 Elsevier Ltd. All rights reserved.
C1 [Narita, Kosuke; Murata, Tetsuhito; Kosaka, Hirotaka; Sudo, Satoru; Wada, Yuji] Univ Fukui, Dept Neuropsychiat, Fukui 9101193, Japan.
   [Hamada, Toshihiko; Yoshida, Haruyoshi] Univ Fukui, Dept Clin & Lab Sci, Fukui 910, Japan.
   [Mizukami, Kimiko] Jin ai Univ, Fac Human Studies, Dept Psychol, Fukui 910, Japan.
   [Narita, Kosuke] Gunma Univ, Grad Sch Med, Dept Psychiat & Human Behav, Gunma, Japan.
C3 University of Fukui; University of Fukui; Gunma University
RP Murata, T (corresponding author), Univ Fukui, Dept Neuropsychiat, Eiheiji Cho, Fukui 9101193, Japan.
EM tmurata@u-fukui.ac.jp
RI Yoshida, Haruyoshi/IRZ-6376-2023; Kosaka, Hirotaka/AFG-5500-2022
OI Kosaka, Hirotaka/0000-0003-2210-5025
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NR 47
TC 29
Z9 33
U1 0
U2 3
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD APR
PY 2008
VL 33
IS 3
BP 305
EP 312
DI 10.1016/j.psyneuen.2007.11.013
PG 8
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA 282LD
UT WOS:000254568400005
PM 18178323
DA 2025-06-11
ER

PT J
AU Patterson, CJ
   Potter, EC
AF Patterson, Charlotte J.
   Potter, Emma C.
TI Sexual Orientation and Sleep Difficulties: Evidence from the National
   Health and Nutrition Examination (NHANES)
SO JOURNAL OF BISEXUALITY
LA English
DT Article
DE bisexuality; NHANES; sexual orientation; sleep difficulties
ID CATEGORICAL VARIABLES; CARDIOMETABOLIC RISK; GENDER-DIFFERENCES;
   MENTAL-HEALTH; GAY MEN; MEDIATION; INSOMNIA; STIGMA; VICTIMIZATION;
   DURATION
AB This study aimed to examine differences in sleep difficulties among adults in the United States (aged 18-59) as a function of sexual orientation and physical health. Data came from the 2013 to 2014 National Health and Nutrition Examination Survey. Participants (n = 4115) reported on demographics, sexual orientation, sleep, number of doctor visits, physical health, and depressive symptoms. In bivariate analyses, sleep difficulties that were confirmed by a healthcare professional were more likely among sexual minority than among heterosexual adults. After controlling for demographic variables, health problems, and depressive symptoms, bisexual adults were more likely than heterosexual adults to report confirmed sleep difficulties. Subsequent analysis revealed that depressive symptoms partially mediated the association of confirmed sleep difficulties and sexual orientation, particularly for bisexual women. Thus, our findings revealed that confirmed sleep difficulties were more common among bisexual adults - especially bisexual women - than among heterosexual or lesbian/gay adults. The results suggest that disparities in sleep, health, and depression warrant further investigation.
C1 [Patterson, Charlotte J.; Potter, Emma C.] Univ Virginia, Dept Psychol, POB 400400, Charlottesville, VA 22904 USA.
C3 University of Virginia
RP Patterson, CJ (corresponding author), Univ Virginia, Dept Psychol, POB 400400, Charlottesville, VA 22904 USA.
EM cjp@virginia.edu
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NR 50
TC 5
Z9 7
U1 0
U2 4
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 1529-9716
EI 1529-9724
J9 J BISEXUALITY
JI J. Bisexuality
PD JAN 2
PY 2020
VL 20
IS 1
BP 1
EP 18
DI 10.1080/15299716.2020.1729288
EA FEB 2020
PG 18
WC Social Sciences, Interdisciplinary
WE Emerging Sources Citation Index (ESCI)
SC Social Sciences - Other Topics
GA KX6GL
UT WOS:000517921100001
DA 2025-06-11
ER

PT J
AU Williams, LH
   Miller, DR
   Fincke, G
   Lafrance, JP
   Etzioni, R
   Maynard, C
   Raugi, GJ
   Reiber, GE
AF Williams, Lisa H.
   Miller, Donald R.
   Fincke, Graeme
   Lafrance, Jean-Philippe
   Etzioni, Ruth
   Maynard, Charles
   Raugi, Gregory J.
   Reiber, Gayle E.
TI Depression and incident lower limb amputations in veterans with diabetes
SO JOURNAL OF DIABETES AND ITS COMPLICATIONS
LA English
DT Article
DE Depression; Diabetes; Veterans; Amputation; Foot ulcer
ID LOWER-EXTREMITY AMPUTATION; RISK-FACTORS; FOOT ULCER; PRIMARY-CARE;
   COMORBID DEPRESSION; METABOLIC SYNDROME; SELF-CARE; ASSOCIATION;
   SYMPTOMS; DISEASE
AB Problem: Depression is associated with a higher risk of macrovascular and microvascular complications and mortality in diabetes, but whether depression is linked to an increased risk of incident amputations is unknown. We examined the association between diagnosed depression and incident non-traumatic lower limb amputations in veterans with diabetes. Methods: This was a retrospective cohort study from 2000-2004 that included 531,973 veterans from the Diabetes Epidemiology Cohorts, a national Veterans Affairs (VA) registry with VA and Medicare data. Depression was defined by diagnostic codes or antidepressant prescriptions. Amputations were defined by diagnostic and procedural codes. We determined the HR and 95% CI for incident non-traumatic lower limb amputation by major (transtibial and above) and minor (ankle and below) subtypes, comparing veterans with and without diagnosed depression and adjusting for demographics, health care utilization, diabetes severity and comorbid medical and mental health conditions. Results: Over a mean 4.1 years of follow-up, there were 1289 major and 2541 minor amputations. Diagnosed depression was associated with an adjusted HR of 1.33 (95% CI: 1.15-1.55) for major amputations. There was no statistically significant association between depression and minor amputations (adjusted HR 1.01, 95% CI: 0.90-1.13). Conclusions: Diagnosed depression is associated with a 33% higher risk of incident major lower limb amputation in veterans with diabetes. Further study is needed to understand this relationship and to determine whether depression screening and treatment in patients with diabetes could decrease amputation rates. (C) 2011 Elsevier Inc. All rights reserved.
C1 [Williams, Lisa H.; Maynard, Charles; Raugi, Gregory J.; Reiber, Gayle E.] VA Hlth Serv Res & Dev Ctr Excellence, Seattle, WA USA.
   [Williams, Lisa H.; Raugi, Gregory J.] Univ Washington, Sch Med, Seattle, WA USA.
   [Miller, Donald R.; Fincke, Graeme; Lafrance, Jean-Philippe] VA Ctr Hlth Qual Outcomes & Econ Res, Bedford, MA USA.
   [Miller, Donald R.; Fincke, Graeme; Lafrance, Jean-Philippe] Boston Univ, Sch Publ Hlth, Boston, MA USA.
   [Etzioni, Ruth] Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA.
   [Maynard, Charles; Reiber, Gayle E.] Univ Washington, Sch Publ Hlth, Seattle, WA 98195 USA.
C3 University of Washington; University of Washington Seattle; Boston
   University; Fred Hutchinson Cancer Center; University of Washington;
   University of Washington Seattle
RP Williams, LH (corresponding author), Grp Hlth Cooperat Puget Sound, 125 16th Ave E,CSB-5, Seattle, WA 98112 USA.
EM lisahw@u.washington.edu
RI Lafrance, Jean-Philippe/C-9113-2013; Maynard, Charles/N-3906-2015
OI Fincke, Benjamin/0000-0003-3167-2929; Maynard,
   Charles/0000-0002-1644-7814; Miller, Donald/0000-0002-7881-8801
FU Sanofi Aventis; GlaxoSmithKline; Merck; VA Epidemiology Merit Review
   Proposal; National Institute of Arthritis and Musculoskeletal and Skin
   Diseases/American Skin Association [F32AR-056380]; Dermatology
   Foundation
FX Dr. Miller has received grant funding from Sanofi Aventis,
   GlaxoSmithKline, and Merck within the last three years. The remaining
   authors have no relevant conflicts of interest to disclose. We would
   like to thank Qing Shao, Madhuri Palnati, and Sae Jong Byun for
   assistance with data analysis and Doug Smith, MD, for his thoughtful
   comments. This project was supported by a VA Epidemiology Merit Review
   Proposal (Dr. Miller). Dr. Williams was supported by F32AR-056380 from
   the National Institute of Arthritis and Musculoskeletal and Skin
   Diseases/American Skin Association and a Dermatology Foundation
   Dermatologist Investigator Research Fellowship.
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NR 47
TC 39
Z9 47
U1 0
U2 12
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1056-8727
EI 1873-460X
J9 J DIABETES COMPLICAT
JI J. Diabetes Complications
PD MAY-JUN
PY 2011
VL 25
IS 3
BP 175
EP 182
DI 10.1016/j.jdiacomp.2010.07.002
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 757HE
UT WOS:000290075300005
PM 20801060
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Yamaguchi, Y
   Yoshikawa, N
   Kagota, S
   Nakamura, K
   Haginaka, J
   Kunitomo, M
AF Yamaguchi, Yu
   Yoshikawa, Noriko
   Kagota, Satomi
   Nakamura, Kazuki
   Haginaka, Jun
   Kunitomo, Masaru
TI Elevated circulating levels of markers of oxidative-nitrative stress and
   inflammation in a genetic rat model of metabolic syndrome
SO NITRIC OXIDE-BIOLOGY AND CHEMISTRY
LA English
DT Article
DE metabolic syndrome; SHR/NDmcr-cp (cp/cp) rat; atherosclerosis; oxidative
   stress; peroxynitrite; C-reactive protein
ID C-REACTIVE PROTEIN; NITRIC-OXIDE; INSULIN-RESISTANCE;
   LIPID-PEROXIDATION; SERUM-LEVELS; DNA-DAMAGE; IN-VIVO; PEROXYNITRITE;
   PLASMA; MYELOPEROXIDASE
AB Metabolic syndrome is a cluster of metabolic diseases that in essence greatly promotes progression of atherosclerosis. We used a genetic model of the metabolic syndrome, the SHR/NDmcr-cp (SHR/cp) rat, from 6 to 40 weeks of age to investigate whether systemic oxidative stress, a major cause of atherosclerosis, increases in this syndrome. Nine-week-old male rats already showed manifestations of metabolic syndrome, including heavier body weight, higher blood pressure and higher levels of serum glucose, insulin and various lipids compared to the age-matched Wistar Kyoto (WKY) rats used as a genetic control. These metabolic parameters gradually progressed with age. Likewise, the serum levels of oxidative stress markers, including lipid peroxides, which oxidatively modify low-density lipoprotein (LDL) and 8-hydroxydeoxyguanosine (8-OHdG), gradually increased in SHR/cp rats. The serum levels of 3-nitrotyrosine and 3-chlorotyrosine also persistently increased, indicating the involvement of peroxynitrite or myeloperoxidase-catalyzed oxidation. In addition, high-sensitivity C-reactive protein (hsCRP), an early marker of inflammation, temporarily increased in SHR/cp rats compared to WKY rats. These findings suggest that oxidative stress, as well as nitrative stress and inflammation, increases in the metabolic syndrome, which may contribute to the development of atherosclerosis. (c) 2006 Elsevier Inc. All rights reserved.
C1 Mukogawa Womens Univ, Dept Pharmacol, Sch Pharmaceut Sci, Nishinomiya, Hyogo 6638179, Japan.
   Mukogawa Womens Univ, Sch Pharmaceut Sci, Dept Analyt Chem, Nishinomiya, Hyogo 6638179, Japan.
C3 Mukogawa Women's University; Mukogawa Women's University
RP Yamaguchi, Y (corresponding author), Mukogawa Womens Univ, Dept Pharmacol, Sch Pharmaceut Sci, 11-68 Koshien Kyuban Cho, Nishinomiya, Hyogo 6638179, Japan.
EM yusan@mwu.mukogawa-u.ac.jp
RI Haginaka, Jun/K-5672-2012
OI Haginaka, Jun/0000-0001-6760-7745
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NR 52
TC 54
Z9 57
U1 0
U2 3
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 1089-8603
EI 1089-8611
J9 NITRIC OXIDE-BIOL CH
JI Nitric Oxide-Biol. Chem.
PD DEC
PY 2006
VL 15
IS 4
BP 380
EP 386
DI 10.1016/j.niox.2006.04.264
PG 7
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA 104KO
UT WOS:000241957500012
PM 16798031
DA 2025-06-11
ER

PT J
AU Onat, A
   Can, G
   Örnek, E
   Çiçek, G
   Ayhan, E
   Dogan, Y
AF Onat, Altan
   Can, Gunay
   Ornek, Ender
   Cicek, Gokhan
   Ayhan, Erkan
   Dogan, Yuksel
TI Serum γ-Glutamyltransferase: Independent Predictor of Risk of Diabetes,
   Hypertension, Metabolic Syndrome, and Coronary Disease
SO OBESITY
LA English
DT Article
ID CARDIOVASCULAR-DISEASE; INSULIN-RESISTANCE; ABDOMINAL OBESITY; OXIDATIVE
   STRESS; HEART-DISEASE; MEN; POPULATION; MORTALITY; ADULTS; DETERMINANTS
AB Serum gamma-glutamyltransferase (GGT) is associated with oxidative stress and hepatic steatosis. The extent to which its value in determining incident cardiometabolic risk (coronary heart disease (CHD), metabolic syndrome (MetS), hypertension and type 2 diabetes) is independent of obesity needs to be further explored in ethnicities. After appropriate exclusions, a cohort of 1,667 adults of a general population (age 52 +/- 11 years) was evaluated prospectively at 4 year's follow-up using partly Cox proportional hazard regressions. GGT activity was measured kinetically, and values were log-transformed for analyses. MetS was identified by Adult Treatment Panel-III criteria modified for male abdominal obesity. Median (interquartile range) GGT activity was 24.9 (17.0; 35.05) U/l in men, 17.0 (12.3; 24.0) U/l in women. In linear regression analysis, while smoking status was not associated, (male) sex, sexdependent age, alcohol usage, BMI, fasting triglycerides and C-reactive protein (CRP) were significant independent determinants of circulating GGT. Each 1-s. d. increment in (= 0.53 ln GGT) GGT activity significantly predicted in each sex incident hypertension (hazard ratio (HR) 1.20 (95% confidence interval (CI) 1.10; 1.31)), and similarly MetS, after adjustment for age, alcohol usage, smoking status, BMI and menopause. Strongest independent association existed with diabetes (HR 1.3 (95% CI 1.1; 1.5)) whereas GGT activity tended to marginally predict CHD independent of total bilirubin but not of BMI. Higher serum total bilirubin levels were protective against CHD risk in women. We conclude that elevated serum GGT confers, additively to BMI, risk of hypertension, MetS, and type 2 diabetes but only mediates adiposity against CHD risk.
C1 [Onat, Altan] Istanbul Univ, Cerrahpasa Med Sch, Dept Cardiol, Istanbul, Turkey.
   [Can, Gunay] Istanbul Univ, Cerrahpasa Med Sch, Dept Publ Hlth, Istanbul, Turkey.
   [Ornek, Ender] Etlik Educ & Res Hosp, Dept Cardiol, Ankara, Turkey.
   [Cicek, Gokhan; Ayhan, Erkan] S Ersek Cardiovasc Surg Ctr, Dept Cardiol, Istanbul, Turkey.
   [Dogan, Yuksel] Bakirkoy Sadi Konuk Educ Hosp, Dept Cardiol, Istanbul, Turkey.
C3 Istanbul University - Cerrahpasa; Istanbul University; Istanbul
   University - Cerrahpasa; Istanbul University; Ankara Etlik Ihtisas
   Egitim ve Arastirma Hastanesi; Dr. Siyami Ersek Cardiac & Vascular
   Surgery Training & Research Hospital; Bakirkoy Dr. Sadi Konuk Research &
   Training Hospital
RP Onat, A (corresponding author), Istanbul Univ, Cerrahpasa Med Sch, Dept Cardiol, Istanbul, Turkey.
EM alt_onat@yahoo.com.tr
RI Can, Günay/AAB-1669-2020; Ayhan, Erkan/ABF-1080-2020; Örnek,
   Ender/AAI-2423-2019; cicek, gokhan/ABF-5286-2021
OI Cicek, Gokhan/0000-0002-5479-5123
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NR 29
TC 71
Z9 75
U1 0
U2 15
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1930-7381
EI 1930-739X
J9 OBESITY
JI Obesity
PD APR
PY 2012
VL 20
IS 4
BP 842
EP 848
DI 10.1038/oby.2011.136
PG 7
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 917AC
UT WOS:000302143300018
PM 21633402
DA 2025-06-11
ER

PT J
AU Hoirisch-Clapauch, S
   Nardi, AE
   Gris, JC
   Brenner, B
AF Hoirisch-Clapauch, Silvia
   Nardi, Antonio E.
   Gris, Jean-Christophe
   Brenner, Benjamin
TI Mental Disorders and Thrombotic Risk
SO SEMINARS IN THROMBOSIS AND HEMOSTASIS
LA English
DT Article
DE venous thromboembolism; depression; schizophrenia; psychosis; mental
   stress; PAI-1; plasminogen activator
ID TISSUE-PLASMINOGEN ACTIVATOR; CORONARY-ARTERY-DISEASE; LONG-TERM
   POTENTIATION; ANTIPSYCHOTIC-DRUGS; VENOUS THROMBOEMBOLISM; MECHANISMS;
   STRESS; WOMEN; COAGULATION; DEPRESSION
AB Patients with psychosis, severe depression, or chronic stress are at increased risk for thromboembolism. Evidence suggests that tissue plasminogen activator (tPA) and plasminogen activator inhibitor-1 (PAI-1) imbalance may play an important role in pathophysiology of mental and thromboembolic disorders. tPA facilitates clot dissolution and participates in several brain functions, including response to stress, learning, and memory. Depression is characterized by high PAI-1 levels, and conditions related to a hypofibrinolytic status, such as polycystic ovary syndrome and metabolic syndrome, are associated with an increased risk for both depression and cardiovascular events. Depression/psychosis may occur when estrogen and progesterone levels decrease. Estrogen inhibits synthesis of transforming growth factor- (TGF-), a protein increasing PAI-1 synthesis, whereas progesterone induces brain-derived neurotrophic factor release, stimulating tPA expression in neurons. Synthetic progestogens (progestins) may cause severe depression. Notably, progestin metabolites, which may prevent synthesis of natural progesterone by feedback, do not cross the blood-brain barrier. Intense suprapubic menstrual cramp, which may relate to difficulty to dissolve clots, correlates with severe premenstrual tension. Exercise, which increases tPA synthesis, has antidepressive and antithrombotic effects. We suggest that thromboembolism and some mental disorders are mechanistically related: tPA-PAI-1 imbalance seems to be a common denominator.
C1 [Hoirisch-Clapauch, Silvia] Hosp Fed Servidores Estado, Dept Hematol, Rio De Janeiro, Brazil.
   [Nardi, Antonio E.] Univ Fed Rio de Janeiro, Inst Psychiat, BR-21941 Rio De Janeiro, Brazil.
   [Gris, Jean-Christophe] Univ Nimes Hosp, Dept Hematol, F-30006 Nimes, France.
   [Brenner, Benjamin] Technion Israel Inst Technol, Dept Hematol & Bone Marrow Transplantat, Haifa, Israel.
C3 Universidade Federal do Rio de Janeiro; Universite de Montpellier; CHU
   de Nimes; Rambam Health Care Campus; Technion Israel Institute of
   Technology
RP Hoirisch-Clapauch, S (corresponding author), Ave Atlantica 434-1101 Leme, BR-22010000 Rio De Janeiro, Brazil.
EM sclapauch@ig.com.br
RI Nardi, Antonio/A-7335-2014; Hoirisch-Clapauch, Silvia/F-3813-2018; GRIS,
   Jean-Christophe/AAA-2923-2019
OI Hoirisch-Clapauch, Silvia/0000-0003-2453-4915; GRIS,
   Jean-Christophe/0000-0002-9899-9910
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NR 72
TC 12
Z9 13
U1 1
U2 15
PU THIEME MEDICAL PUBL INC
PI NEW YORK
PA 333 SEVENTH AVE, NEW YORK, NY 10001 USA
SN 0094-6176
EI 1098-9064
J9 SEMIN THROMB HEMOST
JI Semin. Thromb. Hemost.
PD NOV
PY 2013
VL 39
IS 8
BP 943
EP 949
DI 10.1055/s-0033-1357486
PG 7
WC Hematology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Hematology; Cardiovascular System & Cardiology
GA 242ID
UT WOS:000326231500011
PM 24114008
DA 2025-06-11
ER

PT J
AU Dean, J
   Keshavan, M
AF Dean, Jason
   Keshavan, Matcheri
TI The neurobiology of depression: An integrated view
SO ASIAN JOURNAL OF PSYCHIATRY
LA English
DT Review
DE Depression; Biology; Neurobiology; MDD; Inflammation; Neurogenesis;
   Serotonin; Psychology; Stress; Attachment
ID UNIPOLAR DEPRESSION; METABOLIC SYNDROME; MOOD DISORDERS; STRESS; BRAIN;
   BDNF; INFLAMMATION; ACTIVATION; PLASTICITY; SYSTEMS
AB Major Depressive Disorder (MDD) is one of the most common and debilitating mental disorders; however, its etiology remains unclear. This paper aims to summarize the major neurobiological underpinnings of depression, synthesizing the findings into a comprehensive integrated view. A literature review was conducted using Pubmed. Search terms included "depression" or "MDD" AND "biology", "neurobiology", "inflammation", "neurogenesis", "monoamine", and "stress". Articles from 1995 to 2016 were reviewed with a focus on the connection between different biological and psychological models. Some possible pathophysiological mechanisms of depression include altered neurotransmission, HPA axis abnormalities involved in chronic stress, inflammation, reduced neuroplasticity, and network dysfunction. All of these proposed mechanisms are integrally related and interact bidirectionally. In addition, psychological factors have been shown to have a direct effect on neurodevelopment, causing a biological predisposition to depression, while biological factors can lead to psychological pathology as well. The authors suggest that while it is possible that there are several different endophenotypes of depression with distinct pathophysiological mechanisms, it may be helpful to think of depression as one united syndrome, in which these mechanisms interact as nodes in a matrix. Depressive disorders are considered in the context of the RDoC paradigm, identifying the pathological mechanisms at every translational level, with a focus on how these mechanisms interact. Finally, future directions of research are identified. (C) 2017 Published by Elsevier B.V.
C1 [Dean, Jason] Harvard Med Sch, Brigham & Womens Hosp, 75 Francis St, Boston, MA 02115 USA.
   [Keshavan, Matcheri] Harvard Med Sch, Massachusetts Mental Hlth Ctr, Beth Israel Deaconess Med Ctr, 75 Fenwood Rd, Boston, MA USA.
C3 Harvard University; Harvard University Medical Affiliates; Brigham &
   Women's Hospital; Harvard Medical School; Harvard University; Harvard
   University Medical Affiliates; Beth Israel Deaconess Medical Center;
   Harvard Medical School
RP Dean, J (corresponding author), Harvard Med Sch, Brigham & Womens Hosp, 75 Francis St, Boston, MA 02115 USA.
EM Jdean2@partners.org; mkeshava@bidmc.harvard.edu
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NR 69
TC 477
Z9 534
U1 29
U2 359
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1876-2018
EI 1876-2026
J9 ASIAN J PSYCHIATR
JI Asian J. Psychiatr.
PD JUN
PY 2017
VL 27
BP 101
EP 111
DI 10.1016/j.ajp.2017.01.025
PG 11
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychiatry
GA FB3GS
UT WOS:000406031500017
PM 28558878
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Kahl, KG
   Greggersen, W
   Schweiger, U
   Cordes, J
   Correll, CU
   Frieling, H
   Balijepalli, C
   Lösch, C
   Moebus, S
AF Kahl, Kai G.
   Greggersen, Wiebke
   Schweiger, Ulrich
   Cordes, Joachim
   Correll, Christoph U.
   Frieling, Helge
   Balijepalli, Chakrapani
   Loesch, Christian
   Moebus, Susanne
TI Prevalence of the metabolic syndrome in patients with borderline
   personality disorder: results from a cross-sectional study
SO EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
LA English
DT Article
DE Borderline personality disorder; Diabetes mellitus; Depressive disorder;
   Metabolic syndrome; Second-generation antipsychotics
ID NATIONAL EPIDEMIOLOGIC SURVEY; MYOCARDIAL-INFARCTION; PHYSICAL-ACTIVITY;
   MAJOR DEPRESSION; CARDIOVASCULAR-DISEASE; MENTAL-HEALTH; YOUNG-ADULTS;
   VISCERAL FAT; RISK; MORTALITY
AB Metabolic syndrome (MetS) is an important risk factor for the development of type-2 diabetes and coronary artery disease. We aimed to compare the MetS prevalence in patients with borderline personality disorder (BPD) with comparison subjects followed in primary care from a similar region. One hundred and thirty-five BPD patients according to DSM-IV diagnostic criteria were compared to 1009 subjects from primary care. We used the American Heart Association/National Heart, Lung and Blood Institute criteria to determine the rate of MetS. The age-standardized prevalence of MetS was more than double in patients with BPD compared to comparison subjects (23.3 vs. 10.6 %, p < 0.05). Regarding individual MetS criteria, hyperglycemia was significantly more prevalent in both genders (p < 0.05). Abdominal obesity (p < 0.05) and hypertriglyceridemia (p < 0.05) were significantly higher only in women with BPD. Within BPD patients, an increased rate of MetS was associated with higher BMI (p = 0.004), age (p = 0.03), treatment with second-generation antipsychotics (quetiapine, olanzapine and clozapine; p = 0.032), dysthymia (p = 0.031), panic disorder (p = 0.032), benzodiazepine dependency (p = 0.015) and binge eating disorder p = 0.02). Our results demonstrate an increased MetS rate, dysregulated glucose and lipid metabolism in patients with BPD. Cardiometabolic monitoring and careful screening for physical health conditions among people with BPD is warranted.
C1 [Kahl, Kai G.; Frieling, Helge] Hannover Med Sch, Dept Psychiat Social Psychiat & Psychotherapy, D-30625 Hannover, Germany.
   [Greggersen, Wiebke; Schweiger, Ulrich] Luebeck Med Sch, Dept Psychiat & Psychotherapy, D-23538 Lubeck, Germany.
   [Cordes, Joachim] Univ Dusseldorf, Dept Psychiat & Psychotherapy, D-40629 Dusseldorf, Germany.
   [Correll, Christoph U.] Zucker Hillside Hosp, Glen Oaks, NY 11004 USA.
   [Correll, Christoph U.] Albert Einstein Coll Med, Bronx, NY 10467 USA.
   [Balijepalli, Chakrapani; Loesch, Christian; Moebus, Susanne] Univ Duisburg Essen, Univ Hosp Essen, Inst Med Informat Biometry & Epidemiol, D-45122 Essen, Germany.
C3 Hannover Medical School; Heinrich Heine University Dusseldorf; Northwell
   Health; Montefiore Medical Center; Albert Einstein College of Medicine;
   Yeshiva University; University of Duisburg Essen
RP Kahl, KG (corresponding author), Hannover Med Sch, Dept Psychiat Social Psychiat & Psychotherapy, Carl Neuberg Str 1, D-30625 Hannover, Germany.
EM kahl.kai@mh-hannover.de
RI Correll, Christoph/D-3530-2011; Frieling, Helge/C-5299-2015
OI Moebus, Susanne/0000-0002-0072-5410
FU Sanofi Aventis Deutschland GmbH, Berlin, Germany
FX Kai G. Kahl received Speaker Honoraries from Eli Lilly, AstraZeneca,
   Lundbeck and Servier. Helge Frieling receiced Speaker Honoraria from
   Servier. Christoph U, Correll has been a consultant and/or advisor to or
   has received honoraria from Actelion, AstraZeneca, Boehringer-Ingelheim,
   Bristol-Myers Squibb, Cephalon, Eli Lilly, Intra-Cellular Therapeutics;
   Ortho-McNeill/Janssen/J&J, GSK, Hoffmann-La Roche, Lundbeck, Medicure,
   Otsuka, Pfizer, Schering-Plough, Sepracor/Sunovion, Supernus, Takeda and
   Vanda. GEMCAS was supported by an unrestricted educational research
   grant by Sanofi Aventis Deutschland GmbH, Berlin, Germany.
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Z9 47
U1 0
U2 26
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0940-1334
EI 1433-8491
J9 EUR ARCH PSY CLIN N
JI Eur. Arch. Psych. Clin. Neurosci.
PD APR
PY 2013
VL 263
IS 3
BP 205
EP 213
DI 10.1007/s00406-012-0339-2
PG 9
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA 115MK
UT WOS:000316816100005
PM 22777277
DA 2025-06-11
ER

PT J
AU Gurusamy, J
   Amudhan, S
   Menen, M
   Veerabhadraiah, KB
   Damodharan, D
AF Gurusamy, Jothimani
   Amudhan, Senthil
   Menen, Melwine
   Veerabhadraiah, Kathyayani B.
   Damodharan, Dinakaran
TI Barriers and Needs of Mental Health Nursing Practitioners toward the
   Provision of Physical Health Care for Individuals with Severe Mental
   Illness: Findings from a Cross-Sectional Survey in India
SO ISSUES IN MENTAL HEALTH NURSING
LA English
DT Article
ID NURSES ATTITUDES; ANTIPSYCHOTIC TREATMENT; METABOLIC SYNDROME; TRAINING
   NEEDS; PEOPLE; SCHIZOPHRENIA; MORTALITY; CONFIDENCE; DISORDERS;
   KNOWLEDGE
AB Despite the potential and opportunity for nurses in mental health settings to deliver comprehensive care to individuals with severe mental illnesses, existing evidence indicates inadequacy in providing physical health care. To understand this gap, we examined the mental health nurse's attitudes, practices, training needs, and barriers toward physical healthcare of individuals with severe mental illness and explored the associated socio-demographic differences. All mental health nurses working in an apex mental health care center in India were assessed using a self-administered questionnaire, which included a socio-demographic profile and the Physical Health Attitude Scale (PHASe). Overall, the nurses held positive attitudes, with items related to smoking and confidence toward physical health care delivery showing more positive ratings than those items related to attitude and perceived barriers. Lack of motivation from patients and nurse's workload in provision of psychiatric care were perceived as major barriers. Nurses with lesser years of experience had a slightly more positive attitude. The findings have important implications for mental health nursing practice and training toward strengthening holistic nursing care for individuals with severe mental illness, specifically in countries with limited resources.
C1 [Gurusamy, Jothimani; Veerabhadraiah, Kathyayani B.] Natl Inst Mental Hlth & Neuro Sci NIMHANS, Coll Nursing, Bangalore 560029, India.
   [Amudhan, Senthil] Natl Inst Mental Hlth & Neuro Sci NIMHANS, Dept Epidemiol, Bangalore, India.
   [Menen, Melwine] Natl Inst Mental Hlth & Neuro Sci NIMHANS, Clin Nursing Serv, Bangalore, India.
   [Damodharan, Dinakaran] Natl Inst Mental Hlth Neurosci NIMHANS, Ctr Psychosocial Support Disaster Management, Bangalore, India.
C3 National Institute of Mental Health & Neurosciences - India; National
   Institute of Mental Health & Neurosciences - India; National Institute
   of Mental Health & Neurosciences - India; National Institute of Mental
   Health & Neurosciences - India
RP Gurusamy, J (corresponding author), Natl Inst Mental Hlth & Neuro Sci NIMHANS, Coll Nursing, Bangalore 560029, India.
EM jothisrinivas.jothi@gmail.com
RI Gurusamy, Jothimani/P-6729-2019; Amudhan, Senthil/AAN-6572-2020
OI Gurusamy, Jothimani/0000-0002-3844-6038; Amudhan,
   Senthil/0000-0001-8361-9623; Damodharan, Dinakaran/0000-0002-7359-8168
FU The authors thank all participants for their active participation and
   cooperation.
FX The authors thank all participants for their active participation and
   cooperation.
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NR 53
TC 1
Z9 1
U1 0
U2 3
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 0161-2840
EI 1096-4673
J9 ISSUES MENT HEALTH N
JI Issues Ment. Health Nurs.
PD OCT 3
PY 2023
VL 44
IS 10
SI SI
BP 1009
EP 1019
DI 10.1080/01612840.2023.2262581
EA SEP 2023
PG 11
WC Nursing; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Psychiatry
GA Y5RA7
UT WOS:001079439900001
PM 37819752
DA 2025-06-11
ER

PT J
AU Carpiniello, B
   Pinna, F
   Pili, R
   Velluzzi, F
   Loviselli, A
AF Carpiniello, B.
   Pinna, F.
   Pili, R.
   Velluzzi, F.
   Loviselli, A.
TI MENTAL DISORDERS IN OBESE PATIENTS WITH AND WITHOUT METABOLIC SYNDROME
SO INTERNATIONAL JOURNAL OF PSYCHIATRY IN MEDICINE
LA English
DT Article
DE central obesity; metabolic syndrome; mental disorders; lifetime
   prevalence
ID PSYCHIATRIC COMORBIDITY; DEPRESSION; RISK
AB Objective: The authors sought to evaluate lifetime prevalence of mental disorders in patients affected by metabolic syndrome compared with patients affected by central obesity alone. Methods: One hundred eighty-six (63.5%) patients affected by central obesity and 107 (36.5%) affected by metabolic syndrome according to ICF criteria were interviewed by means of SCID I and SCID II. Results: Axis I and axis II lifetime prevalence were respectively 53.8% and 30.1% among patients with central obesity, 50.5% and 28% among patients with metabolic syndrome, differences which were not significant. No statistically significant differences were found between groups as far as each single axis I and II diagnostic category was considered. Conclusion: Metabolic syndrome is not associated with a higher risk of mental disorders compared to central obesity alone. (Int'l. J. Psychiatry in Medicine 201142:369-375)
C1 [Carpiniello, B.] Univ Cagliari, Dept Publ Hlth, Sect Psychiat & Psychiat Clin, I-09127 Cagliari, Italy.
   [Velluzzi, F.; Loviselli, A.] Univ Policlin, Cagliari, Italy.
C3 University of Cagliari; University of Cagliari; Azienda
   Ospedaliero-Universitaria di Cagliari
RP Carpiniello, B (corresponding author), Univ Cagliari, Dept Publ Hlth, Sect Psychiat & Psychiat Clin, Via Liguria 13, I-09127 Cagliari, Italy.
EM bcarpiniello@iol.it
RI Pinna, Federica/LRU-3388-2024
OI Pinna, Federica/0000-0002-3108-9509
CR [Anonymous], 2006, IDF CONS WORLDW DEF
   [Anonymous], 2000, DIAGN STAT MAN MENT
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NR 15
TC 5
Z9 5
U1 0
U2 15
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0091-2174
EI 1541-3527
J9 INT J PSYCHIAT MED
JI Int. J. Psychiatr. Med.
PY 2011
VL 42
IS 4
BP 369
EP 375
DI 10.2190/PM.42.4.c
PG 7
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 905MH
UT WOS:000301275800003
PM 22530399
DA 2025-06-11
ER

PT J
AU Akillioglu, T
   Bas, M
   Kose, G
AF Akillioglu, Tugce
   Bas, Murat
   Kose, Gizem
TI Restrained, emotional eating and depression can be a risk factor for
   metabolic syndrome
SO NUTRICION HOSPITALARIA
LA English
DT Article
DE Restrained eating; Emotional eating; Obesity; Depression; Metabolic
   syndrome
ID DIETARY RESTRAINT; ADOLESCENT GIRLS; BEHAVIOR; STYLE; ATTITUDES; ADULTS;
   HEALTH; ONSET
AB Introduction: metabolic syndrome (MetS) can have a bidirectional effect on emotional and restrained eating. Objectives: our aims are to find interrelations between MetS and emotional eating, restrained eating, additionally with depression.Methods: cross-sectional study. Participants aged between 18 and 63, and mostly were obese (n = 200). Eating Attitudes Test (EAT-26), Beck Depression Inventory (BDI) and Dutch Eating Behavior Questionnaire (DEBQ) were used to find associations between eating patterns and metabolic syndrome.Results: our study ensured evidences for physiological relations between restrained and emotional eating with MetS. Biochemical parameters showed that restrained eaters were less insulin resistant and participants with MetS had higher emotional eating and lower restrained eating. Besides, restrained eaters had lower triglyceride, homeostasis model assessment-insulin resistance (HOMA-IR), fasting insulin, blood glucose, and higher high-density lipoprotein cholesterol (HDL-C) levels; and emotional eating was parallel with fasting insulin level and HOMA-IR.Conclusions: MetS had strong associations with eating behaviors as restrained, emotional and external. In line with the findings of the study, additionally, women were more susceptible to MetS than men were. In the regulation of restrictive, emotional and external eating behaviors, dietitians and psychology experts should be in cooperation to treat disordered eating patterns.
C1 [Akillioglu, Tugce; Bas, Murat; Kose, Gizem] Acibadem Mehmet Ali Aydinlar Univ, Fac Hlth Sci, Dept Nutr & Dietet, Istanbul, Turkey.
   [Bas, Murat] Acibadem Mehmet Ali Aydinlar Univ, Fac Hlth Sci, Dept Nutr & Dietet, Kayisdagi Caddesi 32, Istanbul, Turkey.
C3 Acibadem University; Acibadem University
RP Bas, M (corresponding author), Acibadem Mehmet Ali Aydinlar Univ, Fac Hlth Sci, Dept Nutr & Dietet, Kayisdagi Caddesi 32, Istanbul, Turkey.
EM murat.bas@acibadem.edu.tr
RI baş, murat/A-2929-2016; Ağır, Gizem/ABD-2042-2020
OI Bas, Murat/0000-0002-0494-301X; Kose, Gizem/0000-0001-6612-6253
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NR 39
TC 1
Z9 1
U1 5
U2 11
PU ARAN EDICIONES, S L
PI MADRID
PA C/ CASTELLO, 128, 1O, MADRID, 28006, SPAIN
SN 0212-1611
EI 1699-5198
J9 NUTR HOSP
JI Nutr. Hosp.
PD NOV-DEC
PY 2022
VL 39
IS 6
BP 1264
EP 1271
DI 10.20960/nh.03947
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 7S9EW
UT WOS:000911054900006
PM 36173197
OA gold
DA 2025-06-11
ER

PT S
AU Malan, L
   Malan, NT
AF Malan, Leone
   Malan, Nico T.
BE Islam, MS
TI Emotional Stress as a Risk for Hypertension in Sub-Saharan Africans: Are
   We Ignoring the Odds?
SO HYPERTENSION: FROM BASIC RESEARCH TO CLINICAL PRACTICE, VOL 2
SE Advances in Experimental Medicine and Biology
LA English
DT Article; Book Chapter
ID LEFT-VENTRICULAR HYPERTROPHY; CARDIOVASCULAR RISK; BLOOD-PRESSURE;
   SOUTH-AFRICA; CARDIOMETABOLIC RISK; SOCIOECONOMIC-STATUS; METABOLIC
   SYNDROME; COPING STRATEGIES; VASCULAR-DISEASE; BLACK-AFRICANS
AB Globally most interventions focus on improving lifestyle habits and treatment regimens to combat hypertension as a non-communicable disease (NCD). However, despite these interventions and improved medical treatments, blood pressure (BP) values are still on the rise and poorly controlled in sub-Saharan Africa (SSA). Other factors contributing to hypertension prevalence, such as chronic emotional stress, might provide some insight for future health policy approaches.
   Currently, Hypertension Society guidelines do not mention emotional stress as a probable cause for hypertension. Recently the 2014 World Global Health reports, suggested that African governments should consider using World Health Organization hypertension data as a proxy indicator for social well-being. However, the possibility that a stressful life and taxing environmental factors might disturb central neural control of BP regulation has largely been ignored in SSA.
   Linking emotional stress to vascular dysregulation is therefore one way to investigate increased cardiometabolic challenges, neurotransmitter depletion and disturbed hemodynamics. Disruption of stress response pathways and subsequent changes in lifestyle habits as ways of coping with a stressful life, and as probable cause for hypertension prevalence in SSA, may be included in future preventive measures. We will provide an overview on emotional stress and central neural control of BP and will include also implications thereof for clinical practice in SSA cohorts.
C1 [Malan, Leone; Malan, Nico T.] North West Univ, Hypertens Africa Res Team HART, Hoffman St,Private Bag X6001, ZA-2520 Potchefstroom, South Africa.
C3 North West University - South Africa
RP Malan, L (corresponding author), North West Univ, Hypertens Africa Res Team HART, Hoffman St,Private Bag X6001, ZA-2520 Potchefstroom, South Africa.
EM leone.malan@nwu.ac.za
RI Malan, Leone/D-7203-2014
OI Malan, Leone/0000-0003-3187-2410
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   van Deventer CA, 2015, J AM SOC HYPERTENS, V9, P104, DOI 10.1016/j.jash.2014.11.007
   van Lill L, 2011, BLOOD PRESSURE, V20, P355, DOI 10.3109/08037051.2011.580529
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NR 98
TC 14
Z9 15
U1 2
U2 7
PU SPRINGER INTERNATIONAL PUBLISHING AG
PI CHAM
PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND
SN 0065-2598
EI 2214-8019
BN 978-3-319-44251-8; 978-3-319-44250-1
J9 ADV EXP MED BIOL
JI Adv.Exp.Med.Biol.
PY 2017
VL 956
BP 497
EP 510
DI 10.1007/5584_2016_37
D2 10.1007/978-3-319-44251-8
PG 14
WC Medicine, Research & Experimental; Peripheral Vascular Disease
WE Book Citation Index – Science (BKCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Cardiovascular System & Cardiology
GA BM2DF
UT WOS:000460878100032
PM 27421968
DA 2025-06-11
ER

PT J
AU Godinho, N
   Morato, M
   Albino-Teixeira, A
   Afonso, AC
   Sousa, T
   Correia-Costa, L
AF Godinho, Nelson
   Morato, Manuela
   Albino-Teixeira, Antonio
   Afonso, Alberto Caldas
   Sousa, Teresa
   Correia-Costa, Liane
TI Gender-related differences in cardiometabolic risk factors and oxidative
   stress among prepubertal children with obesity
SO JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
LA English
DT Article
DE gender differences; oxidative stress; cardiometabolic risk factors;
   childhood obesity
ID NITRIC-OXIDE PRODUCTION; BLOOD-PRESSURE; RENAL-FUNCTION; SEX;
   CHOLESTEROL; MECHANISMS; ATHEROSCLEROSIS; ASSOCIATION; OVERWEIGHT;
   REDUCTION
AB Objectives: Gender-related differences in oxidative stress, nitric oxide bioavailability, and cardiometabolic risk factors were examined in a cross-sectional study involving 313 prepubertal children (8-9 years old) from the generation XXI birth-cohort.Methods: Anthropometric measurements, cardiometabolic variables, and redox markers were assessed, including plasma and urinary isoprostanes (P-Isop, U-Isop), plasma total antioxidant status (P-TAS), serum myeloperoxidase (MPO), plasma and urinary nitrates and nitrites (P-NOX, U-NOX), and urinary hydrogen peroxide (U-H2O2).Results: Girls showed higher levels of total/non-HDL cholesterol, triglycerides, and insulin resistance (HOMA-IR) compared to boys. Notably, U-H2O2 values were lower in girls. When stratifying by body mass index (BMI) and gender, both girls and boys exhibited higher MPO concentration and U-Isop values. Uric acid concentration was higher in overweight and obese girls than in normal weight girls, while no significant differences were observed among boys across BMI categories. Furthermore, U-NOX values differed only in boys, with higher levels observed in overweight and obese individuals compared to those with normal weight. Multivariate analysis, adjusted for age and BMI z-score, demonstrated inverse associations between U-H2O2 and pulse wave velocity values, as well as between U-NOX and total or non-HDL cholesterol, exclusively in boys. In girls, a positive association between U-Isop and HOMA-IR values was observed.Conclusions: In conclusion, gender differentially impacts oxidative stress, nitric oxide bioavailability, and cardiometabolic risk factors in prepubertal children. Prepubertal girls appear more susceptible to oxidative stress-induced metabolic dysfunction, while in boys, elevated levels of redox and nitric oxide bioavailability markers seem to provide protection against arterial stiffness and lipid homeostasis.
C1 [Godinho, Nelson; Afonso, Alberto Caldas; Correia-Costa, Liane] Univ Porto, Inst Ciencias Biomed Abel Salazar, Oporto, Portugal.
   [Morato, Manuela] Univ Porto FFUP, Fac Farm, Dept Ciencias Medicamento, Lab Farmacol, Porto, Portugal.
   [Morato, Manuela] Univ Porto, Fac Farm, LAQV, REQUIMTE, Porto, Portugal.
   [Albino-Teixeira, Antonio; Sousa, Teresa] Univ Porto, Fac Med, Dept Biomed, Unidade Farmacol & Terapeut, Porto, Portugal.
   [Albino-Teixeira, Antonio; Sousa, Teresa] Univ Porto, MedInUP Ctr Invest Farmacol & Inovacao Medicamento, Porto, Portugal.
   [Afonso, Alberto Caldas; Correia-Costa, Liane] Univ Porto, EPIUnit, Inst Saude Publ, Porto, Portugal.
   [Afonso, Alberto Caldas; Correia-Costa, Liane] Univ Porto, Lab Invest Integrat & Translac Saude Populac ITR, Porto, Portugal.
   [Afonso, Alberto Caldas; Correia-Costa, Liane] CHU Santo Antonio, Ctr Materno Infantil Norte, Unidade Nefrol Pediat, Porto, Portugal.
C3 Universidade do Porto; Universidade do Porto; Universidade do Porto;
   Universidade do Porto; Universidade do Porto; Universidade do Porto;
   Universidade do Porto
RP Godinho, N (corresponding author), Univ Porto, Inst Ciencias Biomed Abel Salazar, Oporto, Portugal.
EM n.a.godinho@hotmail.com
RI Morato, Manuela/D-7563-2013; Afonso, Carlos/M-7833-2013; Correia-Costa,
   Liane/JPA-4135-2023; , Teresa/HSF-0698-2023; Albino-Teixeira,
   Antonio/HPI-0713-2023
OI Sousa, Teresa/0000-0001-7230-5020; Correia-Costa,
   Liane/0000-0002-8216-090X; Albino-Teixeira, Antonio/0000-0003-0097-2953;
   Godinho, Nelson/0000-0002-5113-6851; Morato, Manuela/0000-0002-9509-0613
FU FEDER funds from Programa Operacional Factores de
   Competitividade-COMPETE [FCOMP-01-0124-FEDER-028751]; Portuguese
   Foundation for Science and Technology(FCT), Lisbon, Portugal
   [PTDC/DTP-PIC/0239/2012, SFRH/SINTD/95898/2013, SFRH/BPD/112005];
   Calouste Gulbenkian Foundation;  [DL 57/2016]
FX This project was supported by FEDER funds from Programa Operacional
   Factores de Competitividade-COMPETE (FCOMP-01-0124-FEDER-028751), by
   national funds from the Portuguese Foundation for Science and
   Technology(FCT), Lisbon, Portugal (PTDC/DTP-PIC/0239/2012) and by
   Calouste Gulbenkian Foundation. L.C. was supported by FCT(grant
   SFRH/SINTD/95898/2013) and T.S. was supported by FCT and POPH/FSE (EC)
   (Ciencia 2008 Programme, SFRH/BPD/112005) and a contract under the DL
   57/2016 ("Norma Transitoria")
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NR 46
TC 2
Z9 2
U1 1
U2 1
PU WALTER DE GRUYTER GMBH
PI BERLIN
PA GENTHINER STRASSE 13, D-10785 BERLIN, GERMANY
SN 0334-018X
EI 2191-0251
J9 J PEDIATR ENDOCR MET
JI J. Pediatr. Endocrinol. Metab.
PD JAN 29
PY 2024
VL 37
IS 1
BP 42
EP 51
DI 10.1515/jpem-2023-0286
EA DEC 2023
PG 10
WC Endocrinology & Metabolism; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Pediatrics
GA EF3W0
UT WOS:001115497400001
PM 38054937
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Omar, HA
   Almalki, WH
   Shamardl, H
   Mahdy, AY
   Abd El-Latif, HA
AF Omar, Hany A.
   Almalki, Waleed H.
   Shamardl, Hanan
   Mahdy, Abeer Y.
   Abd El-Latif, Hekma A.
TI Lipoic Acid and Coenzyme Q10 Protect Against Lead-induced Toxicity in
   Rats with Metabolic Syndrome
SO INTERNATIONAL JOURNAL OF PHARMACOLOGY
LA English
DT Article
DE Lipoic acid; coenzyme Q10; lead; kidney function; oxidative stress;
   metabolic syndrome
ID HIGH-FAT DIET; OXIDATIVE STRESS; INSULIN-RESISTANCE; WISTAR RATS; CELLS;
   ANTIOXIDANT; MECHANISMS; EXPRESSION; EXPOSURE; INCREASE
AB Obesity may lead to Metabolic Syndrome (MS). The MS is often characterized by oxidative stress which contributes to cellular damage and dysfunction. Lead toxicity is a major health problem especially in obese individuals. Therefore the aim of the current study was to investigate the biochemical and cardiovascular effects caused by lead exposure in rats with metabolic syndrome and suggesting possible protective measures. The MS was induced by feeding rats with high fat diet and fructose in drinking water for 90 days. Matched normal group was used as a control. Rats with metabolic syndrome were allowed to drink water containing lead acetate for 30 days either alone, with alpha-Lipoic Acid (LA) or coenzyme Q10 (CoQ10). At the end of experiment, body weight, systolic blood pressure and heart rate were assessed. Creatinine and uric acid were also determined. Lipid profile, oxidative stress biomarkers, nitric oxide, TNF alpha, calcium, insulin and glucose were determined. The exposure to lead worsens kidney function, oxidative stress and metabolic effects caused by metabolic syndrome. The use of LA or CoQ10 could ameliorate these harmful effects of lead. In conclusion, lead worsens the MS cases due to its ability to induce oxidative stress in rat tissues. The LA and CoQ10 beneficial effects could be attributed to their antioxidant capacity.
C1 [Omar, Hany A.] Beni Suef Univ, Fac Pharm, Dept Pharmacol & Toxicol, Bani Suwayf 62514, Egypt.
   [Omar, Hany A.] Univ Sharjah, Dept Pharmacol, Coll Pharm, Sharjah Inst Med Res, Sharjah 27272, U Arab Emirates.
   [Almalki, Waleed H.; Shamardl, Hanan; Mahdy, Abeer Y.] Umm Al Qura Univ, Coll Pharm, Dept Pharmacol, Mecca, Saudi Arabia.
   [Abd El-Latif, Hekma A.] Cairo Univ, Fac Pharm, Dept Pharmacol & Toxicol, Cairo 11562, Egypt.
C3 Egyptian Knowledge Bank (EKB); Beni Suef University; University of
   Sharjah; Umm Al-Qura University; Egyptian Knowledge Bank (EKB); Cairo
   University
RP Abd El-Latif, HA (corresponding author), Cairo Univ, Fac Pharm, Dept Pharmacol & Toxicol, Cairo 11562, Egypt.
RI Shamardal, Hanan/AAR-4729-2021; Almalki, Waleed/AAD-8858-2021; Omar,
   Hany/B-7440-2013
OI Shamardal, Hanan/0000-0001-7042-5731; Almalki,
   Prof.Dr.Waleed/0000-0001-5890-6030; Omar, Hany/0000-0002-4670-8149
FU Scientific Research and Islamic Heritage Institute - Umm Al-Qura
   University-Holy Makkah, Saudi Arabia [43410012]
FX This study was supported by a research grant number 43410012 from
   Scientific Research and Islamic Heritage Institute - Umm Al-Qura
   University-Holy Makkah, Saudi Arabia.
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NR 33
TC 3
Z9 3
U1 0
U2 13
PU ASIAN NETWORK SCIENTIFIC INFORMATION-ANSINET
PI FAISALABAD
PA 308-LASANI TOWN, SARGODHA RD, FAISALABAD, 38090, PAKISTAN
SN 1811-7775
EI 1812-5700
J9 INT J PHARMACOL
JI Int. J. Pharmacol.
PY 2016
VL 12
IS 3
BP 146
EP 153
DI 10.3923/ijp.2016.146.153
PG 8
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA DS2MS
UT WOS:000380604300002
OA Bronze
DA 2025-06-11
ER

PT J
AU Berkman, LF
   Liu, SY
   Hammer, L
   Moen, P
   Klein, LC
   Kelly, E
   Fay, M
   Davis, K
   Durham, M
   Karuntzos, G
   Buxton, OM
AF Berkman, Lisa F.
   Liu, Sze Yan
   Hammer, Leslie
   Moen, Phyllis
   Klein, Laura Cousino
   Kelly, Erin
   Fay, Martha
   Davis, Kelly
   Durham, Mary
   Karuntzos, Georgia
   Buxton, Orfeu M.
TI Work-Family Conflict, Cardiometabolic Risk, and Sleep Duration in
   Nursing Employees
SO JOURNAL OF OCCUPATIONAL HEALTH PSYCHOLOGY
LA English
DT Article
DE work-family conflict; supervisor support; long work hours;
   cardiometabolic risk; sleep duration
ID CORONARY-HEART-DISEASE; JOB DECISION LATITUDE; SICKNESS ABSENCE; HEALTH
   DISADVANTAGE; LIFE EXPECTANCY; MARITAL STRESS; MULTIPLE ROLE; LONE
   MOTHERS; STRAIN; CARE
AB We investigated associations of work-family conflict and work and family conditions with objectively measured cardiometabolic risk and sleep. Multilevel analyses assessed cross-sectional associations between employee and job characteristics and health in analyses of 1,524 employees in 30 extended-care facilities in a single company. We examined work and family conditions in relation to: (a) validated, cardiometabolic risk score based on measured blood pressure, cholesterol, glycosylated hemoglobin, body mass index, and self-reported tobacco consumption and (b) wrist actigraphy-based sleep duration. In fully adjusted multilevel models, work-to-family conflict but not family-to-work conflict was positively associated with cardiometabolic risk. Having a lower level occupation (nursing assistant vs. nurse) was associated with increased cardiometabolic risk, whereas being married and having younger children at home was protective. A significant Age x Work-to-Family Conflict interaction revealed that higher work-to-family conflict was more strongly associated with increased cardiometabolic risk in younger employees. High family-to-work conflict was significantly associated with shorter sleep duration. Working long hours and having children at home were both independently associated with shorter sleep duration. High work-to-family conflict was associated with longer sleep duration. These results indicate that different dimensions of work-family conflict may pose threats to cardiometabolic health and sleep duration for employees. This study contributes to the research on work-family conflict, suggesting that work-to-family and family-to-work conflict are associated with specific health outcomes. Translating theory and findings to preventive interventions entails recognition of the dimensionality of work and family dynamics and the need to target specific work and family conditions.
C1 [Berkman, Lisa F.; Buxton, Orfeu M.] Harvard Univ, TH Chan Sch Publ Hlth, Ctr Populat & Dev Studies, Cambridge, MA 02138 USA.
   [Berkman, Lisa F.; Buxton, Orfeu M.] Harvard Univ, TH Chan Sch Publ Hlth, Dept Social & Behav Sci, Cambridge, MA 02138 USA.
   [Liu, Sze Yan; Fay, Martha] Harvard Univ, Ctr Populat & Dev Studies, Cambridge, MA 02138 USA.
   [Hammer, Leslie] Portland State Univ, Dept Psychol, Portland, OR 97207 USA.
   [Moen, Phyllis; Kelly, Erin] Univ Minnesota, Dept Sociol, Minneapolis, MN 55455 USA.
   [Moen, Phyllis] Univ Minnesota, Minnesota Populat Ctr, Minneapolis, MN 55455 USA.
   [Klein, Laura Cousino; Buxton, Orfeu M.] Penn State Univ, Dept Biobehav Hlth, University Pk, PA 16802 USA.
   [Klein, Laura Cousino] Penn State Univ, Inst Neurosci, University Pk, PA 16802 USA.
   [Davis, Kelly] Penn State Univ, Dept Human Dev & Family Studies, University Pk, PA 16802 USA.
   [Durham, Mary] Kaiser Permanente, Ctr Hlth Res, Portland, OR USA.
   [Karuntzos, Georgia] RTI Int, Behav Hlth & Criminal Justice Res Div, Res Triangle Pk, NC USA.
   [Buxton, Orfeu M.] Brigham & Womens Hosp, Dept Med, Boston, MA 02115 USA.
C3 Harvard University; Harvard T.H. Chan School of Public Health; Harvard
   University; Harvard T.H. Chan School of Public Health; Harvard
   University; Portland State University; University of Minnesota System;
   University of Minnesota Twin Cities; University of Minnesota System;
   University of Minnesota Twin Cities; Pennsylvania Commonwealth System of
   Higher Education (PCSHE); Pennsylvania State University; Pennsylvania
   State University - University Park; Penn State Behrend; Pennsylvania
   Commonwealth System of Higher Education (PCSHE); Pennsylvania State
   University; Penn State Behrend; Pennsylvania State University -
   University Park; Pennsylvania Commonwealth System of Higher Education
   (PCSHE); Pennsylvania State University; Penn State Behrend; Pennsylvania
   State University - University Park; Kaiser Permanente; Research Triangle
   Institute; Harvard University; Harvard University Medical Affiliates;
   Brigham & Women's Hospital
RP Berkman, LF (corresponding author), Harvard Univ, TH Chan Sch Publ Hlth, Ctr Populat & Dev Studies, 9 Bow St, Cambridge, MA 02138 USA.
EM LBerkman@HSPH.Harvard.edu
RI Liu, Sze/ABB-4170-2021; Klein, Laura/L-4231-2013
OI Chandler, Kelly/0000-0002-1422-1694; Liu, Sze Yan/0000-0002-7148-356X;
   Karuntzos, Georgia/0000-0002-8839-1848; Buxton,
   Orfeu/0000-0001-5057-633X
FU National Institutes of Health; Centers for Disease Control and
   Prevention: Eunice Kennedy Shriver National Institute of Child Health
   and Human Development [U01HD051217, U01HD051218, U01HD051256,
   U01HD051276]; National Institute on Aging [U01AG027669]; Office of
   Behavioral and Social Sciences Research; National Institute for
   Occupational Safety and Health [U01OH008788, U01HD059773]; William T.
   Grant Foundation; Alfred P. Sloan Foundation; National Heart, Lung and
   Blood Institute [R01HL107240]; Administration for Children and Families;
   Sunovion; Teva; Dinsmore LLC; Matsutani America
FX This research was conducted as part of the Work, Family & Health
   Network, which is funded by a cooperative agreement through the National
   Institutes of Health and the Centers for Disease Control and Prevention:
   Eunice Kennedy Shriver National Institute of Child Health and Human
   Development (Grants U01HD051217, U01HD051218, U01HD051256, and
   U01HD051276); the National Institute on Aging (Grant U01AG027669); the
   Office of Behavioral and Social Sciences Research; and the National
   Institute for Occupational Safety and Health (Grants U01OH008788 and
   U01HD059773). Grants from the William T. Grant Foundation, the Alfred P.
   Sloan Foundation, the National Heart, Lung and Blood Institute (Grant
   R01HL107240), and the Administration for Children and Families have
   provided additional funding. Dr. Buxton discloses, outside of the
   reported work and in the last 5 years, investigator-initiated research
   grant support from Sepracor (now Sunovion) and Cephalon (now Teva);
   consulting fees Dinsmore LLC (expert witness testimony), Matsutani
   America (scientific advisory board). The contents of this publication
   are solely the responsibility of the authors and do not necessarily
   represent the official views of these institutes and offices.
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NR 114
TC 98
Z9 114
U1 0
U2 62
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 1076-8998
EI 1939-1307
J9 J OCCUP HEALTH PSYCH
JI J. Occup. Health Psychol.
PD OCT
PY 2015
VL 20
IS 4
BP 420
EP 433
DI 10.1037/a0039143
PG 14
WC Public, Environmental & Occupational Health; Psychology, Applied
WE Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; Psychology
GA CS2FB
UT WOS:000361882100002
PM 25961758
OA Green Accepted, hybrid
DA 2025-06-11
ER

PT J
AU Bungau, AF
   Tit, DM
   Stoicescu, M
   Moleriu, LC
   Muresan, M
   Radu, A
   Brisc, MC
   Ghitea, TC
AF Bungau, Alexa Florina
   Tit, Delia Mirela
   Stoicescu, Manuela
   Moleriu, Lavinia-Cristina
   Muresan, Mariana
   Radu, Ada
   Brisc, Mihaela Cristina
   Ghitea, Timea Claudia
TI Exploring a New Pathophysiological Association in Acne Vulgaris and
   Metabolic Syndrome: The Role of Biogenic Amines and Glutathione
   Peroxidase
SO MEDICINA-LITHUANIA
LA English
DT Article
DE metabolic syndrome; acne severity; glutathione peroxidase; oxidative
   stress; biogenic amines
ID OXIDATIVE STRESS; INSULIN
AB Background and Objectives: Metabolic disorders cause many skin issues, including acne vulgaris. This research investigated the function of glutathione peroxidase (GTPx) and biogenic amines as a potential novel pathophysiological link between metabolic syndrome (MetS) and acne vulgaris. Materials and Methods: The patients were distributed into two groups: metabolic precondition (MPG, n = 78) and control (CG, n = 81). To determine the extent of acne and metabolic preconditioning, patients were subjected to extensive clinical/paraclinical investigations. Additionally, catecholamine levels in urine and GTPx levels in blood were measured. Results: Mild acne was more common in the CG (32.1 vs. 6.4, p < 0.001), and severe acne was more common in the MPG (61.54 vs. 25.9, p < 0.001), with the average age being substantially higher in the MPG (23.81 vs. 21.05, p = 0.002). Significant variations were observed in the paraclinical levels for catecholamines (p < 0.05). In the MPG, most severe acne patients were overweight (52.1%), insulin-resistant (48.8%), or obese (47.9%). Moderate acne was most often linked to obesity (56%), overweight (44%), and insulin resistance (20%). Patients with severe acne (48.83%) had a considerably greater incidence of insulin resistance syndrome (p = 0.039) than those with moderate or severe acne (20%). The presence of two or three metabolic disorders considerably raised the risk of severe acne. Significant differences between groups were observed only in the subgroup of patients with severe acne, with lower values in the MPG (p = 0.015). Significant differences between groups were observed regarding the subgroup of patients with severe acne, with lower DTPx values in the MPG. At the group level, only CG patients with severe acne had reduced GTPx levels. Significant differences in catecholamine values were seen between groups (p < 0.05), independent of acne severity, except for adrenaline in mild acne patients (p = 0.059). Conclusions: The complex connection between GTPx and catecholamines in MetS suggests a significant role of these factors in the pathogenesis of acne associated with this condition, opening new perspectives in the research and treatment of acne in the context of MetS.
C1 [Bungau, Alexa Florina; Tit, Delia Mirela; Muresan, Mariana; Radu, Ada] Univ Oradea, Fac Med & Pharm, Doctoral Sch Biomed Sci, Oradea 410087, Romania.
   [Bungau, Alexa Florina; Muresan, Mariana] Univ Oradea, Fac Med & Pharm, Dept Preclin Disciplines, Oradea 410073, Romania.
   [Tit, Delia Mirela; Radu, Ada; Ghitea, Timea Claudia] Univ Oradea, Fac Med & Pharm, Dept Pharm, Oradea 410028, Romania.
   [Stoicescu, Manuela; Brisc, Mihaela Cristina] Univ Oradea, Fac Med & Pharm, Dept Med Disciplines, Oradea 410073, Romania.
   [Moleriu, Lavinia-Cristina] Victor Babes Univ Med & Pharm, Dept Funct Sci 3, Timisoara 300041, Romania.
C3 University of Oradea; University of Oradea; University of Oradea;
   University of Oradea; Victor Babes University of Medicine & Pharmacy,
   Timisoara
RP Tit, DM (corresponding author), Univ Oradea, Fac Med & Pharm, Doctoral Sch Biomed Sci, Oradea 410087, Romania.; Tit, DM (corresponding author), Univ Oradea, Fac Med & Pharm, Dept Pharm, Oradea 410028, Romania.; Stoicescu, M (corresponding author), Univ Oradea, Fac Med & Pharm, Dept Med Disciplines, Oradea 410073, Romania.
EM prada.alexaflorina@student.uoradea.ro; dtit@uoradea.ro;
   manuela_stoicescu@yahoo.com; moleriu.lavinia@umft.ro;
   mmuresan@uoradea.ro; adaroman96@gmail.com; briscristina@yahoo.com;
   timea.ghitea@csud.uoradea.ro
RI Brisc, Mihaela Cristina/AAC-9003-2022; Bungau, Alexa/AGY-4752-2022; ADA,
   ROMAN/JTV-4617-2023; MURESAN, MARIANA/AAH-3095-2021; Stoicescu,
   Manuela/AAC-9008-2022; Tit, Delia/AAT-5032-2020; Ghitea, Timea
   Claudia/AAJ-4273-2021
OI Tit, Delia Mirela/0000-0002-0296-6592; Ghitea, Timea
   Claudia/0000-0001-8981-1958; Brisc, Mihaela
   Cristina/0000-0003-3603-8070; RADU, ANDREI-FLAVIUS/0000-0002-7625-8177
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NR 43
TC 3
Z9 3
U1 1
U2 6
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1010-660X
EI 1648-9144
J9 MEDICINA-LITHUANIA
JI Med. Lith.
PD MAR
PY 2024
VL 60
IS 3
AR 513
DI 10.3390/medicina60030513
PG 13
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA MJ8F6
UT WOS:001193338600001
PM 38541239
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Seillier, M
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AF Seillier, Marion
   Pouyet, Laurent
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   Nollet, Marie
   Capo, Florence
   Guillaumond, Fabienne
   Peyta, Laure
   Dumas, Jean-Francois
   Varrault, Annie
   Bertrand, Gyslaine
   Bonnafous, Stephanie
   Tran, Albert
   Meur, Gargi
   Marchetti, Piero
   Ravier, Magalie A.
   Dalle, Stephane
   Gual, Philippe
   Muller, Dany
   Rutter, Guy A.
   Servais, Stephane
   Iovanna, Juan L.
   Carrier, Alice
TI Defects in mitophagy promote redox-driven metabolic syndrome in the
   absence of TP53INP1
SO EMBO MOLECULAR MEDICINE
LA English
DT Article
DE autophagy; diabetes; mitochondria; obesity; oxidative stress
ID ADIPOSE-TISSUE; CELL-DEATH; OXIDATIVE STRESS; TUMOR-SUPPRESSOR;
   POTENTIAL LINK; OBESITY; CANCER; AUTOPHAGY; INFLAMMATION; EXPRESSION
AB The metabolic syndrome covers metabolic abnormalities including obesity and type 2 diabetes (T2D). T2D is characterized by insulin resistance resulting from both environmental and genetic factors. A genome-wide association study (GWAS) published in 2010 identified TP53INP1 as a new T2D susceptibility locus, but a pathological mechanism was not identified. In this work, we show that mice lacking TP53INP1 are prone to redox-driven obesity and insulin resistance. Furthermore, we demonstrate that the reactive oxygen species increase in TP53INP1-deficient cells results from accumulation of defective mitochondria associated with impaired PINK/PARKIN mitophagy. This chronic oxidative stress also favors accumulation of lipid droplets. Taken together, our data provide evidence that the GWAS-identified TP53INP1 gene prevents metabolic syndrome, through a mechanism involving prevention of oxidative stress by mitochondrial homeostasis regulation. In conclusion, this study highlights TP53INP1 as a molecular regulator of redox-driven metabolic syndrome and provides a new preclinical mouse model for metabolic syndrome clinical research.
C1 [Seillier, Marion; Pouyet, Laurent; N'Guessan, Prudence; Nollet, Marie; Capo, Florence; Guillaumond, Fabienne; Iovanna, Juan L.; Carrier, Alice] CRCM, INSERM, U1068, Marseille, France.
   [Seillier, Marion; Pouyet, Laurent; N'Guessan, Prudence; Nollet, Marie; Capo, Florence; Guillaumond, Fabienne; Iovanna, Juan L.; Carrier, Alice] Inst Paoli Calmettes, Marseille, France.
   [Seillier, Marion; Pouyet, Laurent; N'Guessan, Prudence; Nollet, Marie; Capo, Florence; Guillaumond, Fabienne; Iovanna, Juan L.; Carrier, Alice] Aix Marseille Univ, Marseille, France.
   [Seillier, Marion; Pouyet, Laurent; N'Guessan, Prudence; Nollet, Marie; Capo, Florence; Guillaumond, Fabienne; Iovanna, Juan L.; Carrier, Alice] CRCM, CNRS, UMR7258, Marseille, France.
   [Peyta, Laure; Dumas, Jean-Francois; Servais, Stephane] INSERM, Nutr Croissance & Canc N2C, U1069, Tours, France.
   [Varrault, Annie; Bertrand, Gyslaine; Ravier, Magalie A.; Dalle, Stephane; Muller, Dany] Univ Montpellier I, CNRS, INSERM, IGF,UMR5203,U661, Montpellier, France.
   [Varrault, Annie; Bertrand, Gyslaine; Ravier, Magalie A.; Dalle, Stephane; Muller, Dany] Univ Montpellier 2, CNRS, INSERM, IGF,UMR5203,U661, Montpellier, France.
   [Bonnafous, Stephanie; Tran, Albert; Gual, Philippe] Fac Med Nice, INSERM, Team Hepat Complicat Obes 8, U1065,C3M, F-06034 Nice, France.
   [Bonnafous, Stephanie; Tran, Albert; Gual, Philippe] Univ Nice Sophia Antipolis, F-06189 Nice, France.
   [Bonnafous, Stephanie; Tran, Albert; Gual, Philippe] Ctr Hosp Univ Nice, Hop Archet, Pole Digestif, Nice, France.
   [Meur, Gargi; Rutter, Guy A.] Univ London Imperial Coll Sci Technol & Med, Dept Med, Cell Biol, London, England.
   [Marchetti, Piero] Univ Pisa, Islet Cell Lab, Cisanello Hosp, Pisa, Italy.
C3 UNICANCER; Institut Paoli-Calmette (IPC); Institut National de la Sante
   et de la Recherche Medicale (Inserm); Aix-Marseille Universite;
   UNICANCER; Institut Paoli-Calmette (IPC); Aix-Marseille Universite;
   UNICANCER; Institut Paoli-Calmette (IPC); Aix-Marseille Universite;
   Institut National de la Sante et de la Recherche Medicale (Inserm);
   Centre National de la Recherche Scientifique (CNRS); CNRS - National
   Institute for Biology (INSB); Institut National de la Sante et de la
   Recherche Medicale (Inserm); Centre National de la Recherche
   Scientifique (CNRS); CNRS - National Institute for Biology (INSB);
   Institut National de la Sante et de la Recherche Medicale (Inserm);
   Universite de Montpellier; Universite de Montpellier; Centre National de
   la Recherche Scientifique (CNRS); CNRS - National Institute for Biology
   (INSB); Institut National de la Sante et de la Recherche Medicale
   (Inserm); Universite Cote d'Azur; Institut National de la Sante et de la
   Recherche Medicale (Inserm); Universite Cote d'Azur; CHU Nice; Imperial
   College London; University of Pisa
RP Carrier, A (corresponding author), CRCM, INSERM, U1068, Marseille, France.
EM alice.carrier@inserm.fr
RI bertrand, gyslaine/AAC-6716-2020; Gual, Philippe/P-9833-2019; Dalle,
   Stephane/E-4552-2018; Dumas, Jean-François/AAN-5035-2020; Iovanna,
   Juan/M-9805-2017; SERVAIS, Stephane/Q-6057-2017; Capo,
   Florence/X-1004-2018; Nollet, Marie/M-2752-2017; Gual,
   Philippe/M-8787-2017; Marchetti, Piero/J-7439-2013; Dumas,
   Jean-Francois/S-7486-2017; Ravier, Magalie/N-6934-2017; Guillaumond,
   Fabienne/E-8265-2017
OI SERVAIS, Stephane/0000-0002-3127-9679; SEILLIER-TURINI,
   Marion/0000-0003-3815-1755; Capo, Florence/0000-0002-1491-292X; Nollet,
   Marie/0000-0002-9667-8216; Gual, Philippe/0000-0001-7393-8356; Rutter,
   Guy/0000-0001-6360-0343; Marchetti, Piero/0000-0003-4907-0635; Dumas,
   Jean-Francois/0000-0002-2293-6606; Dalle, Stephane/0000-0002-3423-4548;
   Ravier, Magalie/0000-0001-6607-6559; Meur, Gargi/0000-0002-8466-2997;
   Guillaumond, Fabienne/0000-0001-7456-7315
FU Institut National de la Sante et de la Recherche Medicale; Centre
   National de la Recherche Scientifique; Institut National du Cancer;
   Association pour la Recherche sur le Cancer; La Ligue Nationale contre
   le Cancer; University of Nice; Programme Hospitalier de Recherche
   Clinique (Centre Hospitalier Universitaire of Nice); charity
   (Association Francaise pour l'Etude du Foie (AFEF/LFB)); charity
   (European Foundation for the study of Diabetes EFSD/Lilly); French
   Government (National Research Agency, ANR) through the 'Investments for
   the Future' LABEX SIGNALIFE: program [ANR-11-LABX-0028-01]; Wellcome
   Trust [WT098424AIA]; MRC [MR/J0003042/1]; Royal Society; MRC
   [MR/K001981/1] Funding Source: UKRI
FX We are grateful to the IBDML electron microscopy facilities (PICsL
   platform), to Laurence Borge (cell culture platform of
   Marseille/Luminy), to Karim Sari, Regis Vitestelle and Romain Magro for
   assistance with the use of the animal housing facility, to Fabrice
   Gianardi and Gilles Warcollier for assistance with the use of the
   Laboratoire d'Exploration Fonctionnelle de Luminy, to Marie-Noelle
   Lavaut and Stephane Garcia for support in histological analysis, and to
   Lionel Chasson (Histology Platform of CIML) for support in confocal
   microscopy analyses. We also thank Rose-Patricia Spoto for preparation
   of tail of mice DNA for genotyping, Thomas Bonacci for help in Western
   blotting, Jacques Nunes and Marie-Christine Alessi for advices in HFD
   protocol, and Mathias Chamaillard and Fatima Mechta-Grigoriou for
   helpful discussions. The authors were supported by Institut National de
   la Sante et de la Recherche Medicale, Centre National de la Recherche
   Scientifique, Institut National du Cancer, Association pour la Recherche
   sur le Cancer and La Ligue Nationale contre le Cancer. This work was
   also supported by grants from the University of Nice, the Programme
   Hospitalier de Recherche Clinique (Centre Hospitalier Universitaire of
   Nice), charities (Association Francaise pour l'Etude du Foie (AFEF/LFB)
   to PG, European Foundation for the study of Diabetes EFSD/Lilly to PG)
   and by the French Government (National Research Agency, ANR) through the
   'Investments for the Future' LABEX SIGNALIFE: program reference
   #ANR-11-LABX-0028-01. G.A.R. was supported by Wellcome Trust Senior
   Investigator (WT098424AIA), MRC Programme (MR/J0003042/1) and Royal
   Society Wolfson Research Merit Awards. M.S. was supported by Association
   pour la Recherche sur le Cancer. A.C. and S.S. thank the NACRe (Reseau
   National Alimentation Cancer Recherche) Network for collaboration
   linking.
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NR 57
TC 36
Z9 39
U1 0
U2 25
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1757-4676
EI 1757-4684
J9 EMBO MOL MED
JI EMBO Mol. Med.
PD JUN
PY 2015
VL 7
IS 6
BP 802
EP 818
DI 10.15252/emmm.201404318
PG 17
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA CJ7OP
UT WOS:000355686400009
PM 25828351
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Li, LY
   Liu, SF
   Zhuang, JL
   Li, MM
   Huang, ZP
   Chen, YH
   Chen, XR
   Chen, CN
   Lin, S
   Ye, LC
AF Li, Lin-yi
   Liu, Shu-fen
   Zhuang, Jian-long
   Li, Mi-mi
   Huang, Zheng-ping
   Chen, Yan-hong
   Chen, Xiang-rong
   Chen, Chun-nuan
   Lin, Shu
   Ye, Li-chao
TI Recent research progress on metabolic syndrome and risk of Parkinson's
   disease
SO REVIEWS IN THE NEUROSCIENCES
LA English
DT Article
DE insulin resistance; metabolic syndrome; oxidative stress; Parkinson's
   disease; risk factors; treatment
ID MPTP MOUSE MODEL; NIGRA PARS-COMPACTA; C-REACTIVE PROTEIN;
   ALPHA-SYNUCLEIN; INSULIN-RESISTANCE; OXIDATIVE STRESS; SUBSTANTIA-NIGRA;
   CELL-DEATH; CARDIOVASCULAR RISK; ALZHEIMERS-DISEASE
AB Parkinson's disease (PD) is one of the most widespread neurodegenerative diseases. PD is associated with progressive loss of substantia nigra dopaminergic neurons, including various motor symptoms (e.g., bradykinesia, rigidity, and resting tremor), as well as non-motor symptoms (e.g., cognitive impairment, constipation, fatigue, sleep disturbance, and depression). PD involves multiple biological processes, including mitochondrial or lysosomal dysfunction, oxidative stress, insulin resistance, and neuroinflammation. Metabolic syndrome (MetS), a collection of numerous connected cerebral cardiovascular conditions, is a common and growing public health problem associated with many chronic diseases worldwide. MetS components include central/abdominal obesity, systemic hypertension, diabetes, and atherogenic dyslipidemia. MetS and PD share multiple pathophysiological processes, including insulin resistance, oxidative stress, and chronic inflammation. In recent years, MetS has been linked to an increased risk of PD, according to studies; however, the specific mechanism remains unclear. Researchers also found that some related metabolic therapies are potential therapeutic strategies to prevent and improve PD. This article reviews the epidemiological relationship between components of MetS and the risk of PD and discusses the potentially relevant mechanisms and recent progress of MetS as a risk factor for PD. Furthermore, we conclude that MetS-related therapies are beneficial for the prevention and treatment of PD.
C1 [Li, Lin-yi; Liu, Shu-fen; Li, Mi-mi; Huang, Zheng-ping; Chen, Chun-nuan; Ye, Li-chao] Fujian Med Univ, Affiliated Hosp 2, Dept Neurol, 34 North Zhongshan Rd, Quanzhou 362000, Fujian, Peoples R China.
   Fujian Med Univ, Ctr Neurol & Metab Res, Affiliated Hosp 2, Quanzhou 362000, Fujian, Peoples R China.
   Garvan Inst Med Res, Grp Neuroendocrinol, 384 Victoria St, Sydney, NSW, Australia.
   [Zhuang, Jian-long] QuanzhouWomens & Childrens Hosp, Prenatal Diag Ctr, Quanzhou 362000, Peoples R China.
   [Chen, Yan-hong] Shishi Gen Hosp, Dept Neurol, Quanzhou 362000, Fujian, Peoples R China.
   [Chen, Xiang-rong] Fujian Med Univ, Affiliated Hosp 2, Dept Neurosurg, Quanzhou 362000, Fujian, Peoples R China.
C3 Fujian Medical University; Fujian Medical University; Garvan Institute
   of Medical Research; Fujian Medical University
RP Chen, CN; Ye, LC (corresponding author), Fujian Med Univ, Affiliated Hosp 2, Dept Neurol, 34 North Zhongshan Rd, Quanzhou 362000, Fujian, Peoples R China.; Lin, S (corresponding author), Fujian Med Univ, Ctr Neurol & Metab Res, Affiliated Hosp 2, Quanzhou 362000, Fujian, Peoples R China.; Lin, S (corresponding author), Garvan Inst Med Res, Grp Neuroendocrinol, 384 Victoria St, Sydney, NSW, Australia.
EM chenchunnuan1983@aliyun.com; shulin1956@126.com; yelichao@126.com
RI Chen, Xiangrong/C-3113-2016; chen, yanhong/JVE-0289-2024; Lin,
   Shu/A-4361-2010; Zhang, Jinzhe/IUN-4156-2023
FU Science and Technology Bureau of Quanzhou [2020CT003, 2019C075R,
   2022C025R]; Fujian Provincial Department of Science and Technology
   [2019J01164]; Fujian Provincial Health Technology Project [2019-1-54];
   Natural Science Foundation of Fujian Province, China [2022J01793]
FX This work was supported by the Science and Technology Bureau of Quanzhou
   (grant numbers 2020CT003, 2019C075R and 2022C025R), the Fujian
   Provincial Department of Science and Technology (grant number
   2019J01164), and the Fujian Provincial Health Technology Project (grant
   number 2019-1-54), and the Natural Science Foundation of Fujian
   Province, China (grant number 2022J01793).
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NR 152
TC 19
Z9 19
U1 1
U2 7
PU WALTER DE GRUYTER GMBH
PI BERLIN
PA GENTHINER STRASSE 13, D-10785 BERLIN, GERMANY
SN 0334-1763
EI 2191-0200
J9 REV NEUROSCIENCE
JI Rev. Neurosci.
PD OCT 26
PY 2023
VL 34
IS 7
BP 719
EP 735
DI 10.1515/revneuro-2022-0093
EA DEC 2022
PG 17
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA T5JV1
UT WOS:000920409300001
PM 36450297
DA 2025-06-11
ER

PT J
AU Li, CX
   Xia, JH
   Zhu, WJ
   Xin, LL
   An, CP
   Yang, SL
   Li, K
AF Li, Chenxiao
   Xia, Jihan
   Zhu, Wenjuan
   Xin, Leilei
   An, Cuiping
   Yang, Shulin
   Li, Kui
TI Systemic overexpression of the 11β-HSD1 promotes endoplasmic reticulum
   stress in multiple tissues and the development of metabolic syndrome in
   mice
SO MOLECULAR MEDICINE REPORTS
LA English
DT Article
DE 11 beta-HSD1; systemic overexpression; endoplasmic reticulum stress;
   hepatic lipidosis; metabolic syndrome
ID 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1; ADIPOSE-TISSUE; PREVALENCE;
   OBESITY
AB Glucocorticoids are associated with lipid metabolism and their abnormal expression has an important function in the development of metabolic syndrome. The 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1) is a metabolic enzyme of glucocorticoids and may be a potential drug target for the treatment of metabolic syndrome. However, the association between the systemic expression of 11 beta-HSD1 and metabolic syndrome remains to be elucidated. The present study used a cytomegalovirus promoter to obtain mice that systemically overexpressed the 11 beta-HSD1 gene. The transgenic mice and negative control groups received a high-fat diet at the age of 10 weeks in order to induce metabolic syndrome and this diet was continued for 12 weeks. Several indicators, including body weight, blood glucose, glucose tolerance and insulin resistance, were monitored in vivo. In addition, the protein expression levels of 11 beta-HSD1 and DNA damage inducible transcript 3 were detected and the histopathology of important tissues for metabolic syndrome were analyzed. The current findings revealed that the body weights of transgenic mice were significantly higher compared with the control group before and during the periods of high fat diet induction. Transgenic mice also exhibited significantly impaired glucose tolerance, insulin resistance, endoplasmic reticulum stress and increased metabolic syndrome-associated biochemical indicators in the blood and severely impaired liver and kidney functions. The present study successfully established a 11 beta-HSD1 systemic overexpression mouse model that exhibited typical characteristics of metabolic syndrome and may be useful for future studies of metabolic syndrome.
C1 [Li, Chenxiao; Xia, Jihan; Zhu, Wenjuan; Xin, Leilei; An, Cuiping; Yang, Shulin; Li, Kui] Chinese Acad Agr Sci, Inst Anim Sci, State Key Lab Anim Nutr, 2 Yuanmingyuan West Rd, Beijing 100193, Peoples R China.
   [Li, Kui] Chinese Acad Agr Sci, Agr Genomes Inst Shenzhen, Shenzhen 518120, Guangdong, Peoples R China.
C3 Chinese Academy of Agricultural Sciences; Institute of Animal Science,
   CAAS; Chinese Academy of Agricultural Sciences; Agriculture Genomes
   Institute at Shenzhen, CAAS
RP Yang, SL (corresponding author), Chinese Acad Agr Sci, Inst Anim Sci, State Key Lab Anim Nutr, 2 Yuanmingyuan West Rd, Beijing 100193, Peoples R China.
EM yangshulin@caas.cn
RI Yang, Shulin/K-7072-2017; Xia, Jihan/GLQ-5273-2022; Zhu,
   Weihang/G-6668-2019
OI Xia, Jihan/0000-0002-0035-0727
FU National Natural Science Foundation of China [31372276]; National Basic
   Research Program of China [2015CB943100]; National Science and
   Technology Major Project [2016ZX08006-001]; State Key Laboratory of
   Animal Nutrition [2004DA125184G1602]; Agricultural Science and
   Technology Innovation Program [ASTIP-IAS05, ASTIP-IAS-TS-4]
FX The current study was supported by The National Natural Science
   Foundation of China (grant no. 31372276), The National Basic Research
   Program of China (grant no. 2015CB943100), National Science and
   Technology Major Project (grant no. 2016ZX08006-001), The State Key
   Laboratory of Animal Nutrition (grant no. 2004DA125184G1602) and The
   Agricultural Science and Technology Innovation Program (grant nos.
   ASTIP-IAS05 and ASTIP-IAS-TS-4).
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NR 18
TC 4
Z9 7
U1 0
U2 6
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1791-2997
EI 1791-3004
J9 MOL MED REP
JI Mol. Med. Rep.
PD NOV
PY 2017
VL 16
IS 5
BP 7738
EP 7744
DI 10.3892/mmr.2017.7530
PG 7
WC Oncology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Research & Experimental Medicine
GA FM0ZU
UT WOS:000414698900260
PM 28944856
OA Bronze
DA 2025-06-11
ER

PT J
AU Kumar, R
   Rizvi, M
   Saraswat, S
AF Kumar, Rupal
   Rizvi, Moattar
   Saraswat, Shubhra
TI Obesity and Stress: A Contingent Paralysis
SO INTERNATIONAL JOURNAL OF PREVENTIVE MEDICINE
LA English
DT Review
DE Abdominal fat; hypothalamo-hypophyseal system; ideal body weight;
   obesity; social stress
ID EARLY-LIFE STRESS; PSYCHOLOGICAL STRESS; SOCIOECONOMIC-STATUS;
   PSYCHOSOCIAL STRESS; PERCEIVED STRESS; EATING BEHAVIOR; NEUROPEPTIDE-Y;
   FOOD CRAVINGS; HEALTH; CORTISOL
AB Two highly overriding problems that the society is facing today are stress and obesity. This narrative review article explains the vicious cycle of how stress leads to obesity and vice versa. Stress and obesity are interconnected to each other through different lines of cognition, behavior, and physiology. Stress can interfere with cognitive processes like self-regulation. Stress can also influence behavior by indulging in overeating of foods that are high in calories, fat, and sugar. Stress also invigorates the generation of biochemical hormones and peptides, for example, leptin, ghrelin, and neuropeptide Y. This article also extracts the contribution of weight stigma and social stress in producing obesity in an obesogenic process. Recent Studies describe that psychological distress and elevated cortisol secretion promote abdominal fat, a feature of the metabolic syndrome, improvements in mindfulness, chronic stress, and cortisol awakening response (CAR) were associated with reductions in abdominal fat. Mindfulness intervention for stress suggests that mindfulness training improves eating patterns and the CAR, which may reduce abdominal fat over time. Obesity has a multifaceted etiology. In this review, several factors of stress are identified that affect the development of obesity. This review also provides valuable insight into the relationship between obesity and stress.
C1 [Kumar, Rupal] Manav Rachna Int Inst & Studies MRIIRS, Fac Allied Hlth Sci, Dept Nutr & Dietet, Faridabad, India.
   [Rizvi, Moattar] Manav Rachna Int Inst & Studies MRIIRS, Fac Allied Hlth Sci, Dept Physiotherapy, Faridabad, Haryana, India.
   [Saraswat, Shubhra] Dayal bagh Educ Inst, Dept BVoc Food Proc, Agra, Uttar Pradesh, India.
C3 Manav Rachna International Institute of Research & Studies; Manav Rachna
   International Institute of Research & Studies; Dayalbagh Educational
   Institute (DEI)
RP Kumar, R (corresponding author), Manav Rachna Int Inst & Studies MRIIRS, Fac Allied Hlth Sci, Dept Nutr & Dietet, Faridabad, India.
EM rupalkmr@gmail.com
RI Rizvi, Moattar/ABG-9110-2021
OI Rizvi, Moattar/0000-0001-8424-7163
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NR 76
TC 31
Z9 33
U1 3
U2 23
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, Maharashtra, INDIA
SN 2008-7802
EI 2008-8213
J9 INT J PREVENTIVE MED
JI Int. J. Preventive Med.
PD JAN-DEC
PY 2022
VL 13
IS 1
DI 10.4103/ijpvm.IJPVM_427_20
PG 9
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA 3O6CR
UT WOS:000836923700011
PM 35958362
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Kollia, N
   Panagiotakos, D
   Georgousopoulou, E
   Chrysohoou, C
   Yannakoulia, M
   Stefanadis, C
   Chatterji, S
   Haro, JM
   Papageorgiou, C
   Pitsavos, C
AF Kollia, Natasa
   Panagiotakos, Demosthenes
   Georgousopoulou, Ekavi
   Chrysohoou, Christina
   Yannakoulia, Mary
   Stefanadis, Christodoulos
   Chatterji, Somnath
   Haro, Josep Maria
   Papageorgiou, Charalabos
   Pitsavos, Christos
CA ATTICA Study investigators
TI Exploring the path between depression, anxiety and 10-year
   cardiovascular disease incidence, among apparently healthy Greek
   middle-aged adults: The ATTICA study
SO MATURITAS
LA English
DT Article
DE Depression; Anxiety; Psychological distress; Cardiovascular disease; CVD
   risk factors; Mediation
ID ALL-CAUSE; EPIDEMIOLOGY; ASSOCIATIONS; POPULATION; RISK
AB Objectives: Although there is substantial evidence that psychological factors play an important role in the onset and course of cardiovascular disease (CVD), less is known about their combined effect and the pathways by which they affect cardiovascular health. The present work aimed to prospectively explore the effects of depression and anxiety on the 10-year CVD incidence, in relation to other lifestyle determinants, as linking factors in the context of the ATTICA study. Study design/Main outcome measures: The ATTICA study is a population based, health and nutrition prospective cohort study (2002-2012), during which 853 middle-aged participants without a history of CVD [453 men (aged 45 13 years) and 400 women (aged 44 18 years)], underwent psychological evaluations at enrollment. The latent trait of depression and anxiety combined measure was estimated and referred as "Psychological distress"; path analysis was applied to describe the relationships among the different factors.
   Results: "Psychological distress" was positively associated with the 10-year CVD incidence (adjusted OR per 10 units: 1.4, 95% CI: 1.1, 1.7). Three linking pathways were revealed: sedentariness, inflammation and metabolic syndrome. Moreover, "Psychological distress" mediated the association between socioeconomic status (SES) and CVD, with participants of low SES scoring higher on the psychological measure (adjusted linear regression coefficient b: -7.1, 95% CI: -9.7, -4.5).
   Conclusions: Lifestyle and clinical factors seem to link psychological distress with CVD development. Joint psychological assessments should be considered for inclusion in CVD preventive strategies, which should incorporate interventions for interrupting the linking pathways.
C1 [Kollia, Natasa; Panagiotakos, Demosthenes; Georgousopoulou, Ekavi; Yannakoulia, Mary] Harokopio Univ, Sch Hlth Sci & Educ, Dept Sci Dietet & Nutr, Athens, Greece.
   [Chrysohoou, Christina; Stefanadis, Christodoulos; Pitsavos, Christos] Univ Athens, Sch Med, Cardiol Clin 1, Athens, Greece.
   [Chatterji, Somnath] WHO, Informat Evidence & Res, Geneva, Switzerland.
   [Haro, Josep Maria] Univ Barcelona, Parc Sanitari St Joan de Deu, Barcelona, Spain.
   [Papageorgiou, Charalabos] Univ Athens, Sch Med, Dept Psychiat, Athens, Greece.
C3 Harokopio University Athens; National & Kapodistrian University of
   Athens; Athens Medical School; World Health Organization; University of
   Barcelona; Athens Medical School; National & Kapodistrian University of
   Athens
RP Panagiotakos, D (corresponding author), Harokopio Univ, 70 Eleftheriou Venizelou Ave, Athens 17661, Attica, Greece.
EM d.b.panagiotakos@usa.net
RI Haro, Josep Maria/D-1423-2011; CHATTERJI, Somnath/ABE-6832-2020;
   Panagiotakos, Demosthenes/K-8294-2019; Georgousopoulou,
   Ekavi/AAC-2563-2019; Stefanadis, Christodoulos/ABH-2232-2020
OI Chrysohoou, Christina/0000-0002-6340-3996; Georgousopoulou,
   Ekavi/0000-0002-0592-3838; Yannakoulia, Mary/0000-0003-2171-7337;
   Stefanadis, Christodoulos/0000-0001-5974-6454; Papageorgiou,
   Charalabos/0000-0001-7635-1956
FU Coca-Cola Company; Hellenic Cardiology Society (HCS); Hellenic
   Atherosclerosis Society (HAS); European Union [635316]
FX D. Panagiotakos and E. Georgousopoulou received research grants from the
   Coca-Cola Company. The ATTICA study is supported by research grants from
   the Hellenic Cardiology Society (HCS2002) and the Hellenic
   Atherosclerosis Society (HAS2003). This paper has been conducted within
   the Ageing Trajectories of Health: Longitudinal Opportunities and
   Synergies (ATHLOS) project. The ATHLOS project has received funding from
   the European Union's Horizon 2020 research and innovation program under
   grant agreement no. 635316. The funding sources had no involvement in
   the collection, analysis, or interpretation of data, in writing the
   report or in the decision to submit the article for publication.
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NR 37
TC 21
Z9 21
U1 1
U2 8
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0378-5122
EI 1873-4111
J9 MATURITAS
JI Maturitas
PD DEC
PY 2017
VL 106
BP 73
EP 79
DI 10.1016/j.maturitas.2017.09.005
PG 7
WC Geriatrics & Gerontology; Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Obstetrics & Gynecology
GA FP6ZF
UT WOS:000417775400008
PM 29150168
DA 2025-06-11
ER

PT J
AU Esh, N
   Michael, S
   Paetzholdt, J
   Samaras, K
AF Esh, Nicole
   Michael, Sarah
   Paetzholdt, Jonathan
   Samaras, Katherine
TI Bridging public and private health services to best meet the
   cardiometabolic needs of people with severe mental illness: a
   retrospective cohort study
SO AUSTRALASIAN PSYCHIATRY
LA English
DT Article
DE Severe mental illness; cardiometabolic disease; cardiometabolic
   monitoring; psychotic disorders; mood disorders
ID CARDIOVASCULAR MORTALITY; METABOLIC SYNDROME; RISK-FACTORS; DISPARITIES;
   INTENSITY; EXERCISE; OBESITY; IMPACT; LIFE
AB Objective Cardiovascular disease is the leading cause of premature mortality in people with severe mental illness (SMI). Despite this, there lacks consensus regarding the most appropriate platform to monitor and treat cardiometabolic risk factors in this cohort. The current study aims to evaluate the effectiveness of tailored cardiometabolic healthcare in a private, GP-led clinic for people with SMI. Method A total of 63 adults with SMI were referred to a private GP-led cardiometabolic clinic from a neighbouring inner-city mental health service, where they received individualised cardiometabolic healthcare free-of-charge between 2014 and 2020. Paired t test was used to measure change in cardiometabolic data over the course of treatment. Chi-squared and Fisher's Exact tests were used to examine differences in demographic data and client engagement. Results Over a mean period of 9 months, there was a significant mean reduction of weight (2.1 kg), BMI (0.72 kg/m2) and waist circumference (6 cm). Engagement over a longer period was associated with stable accommodation and improved cardiometabolic outcomes. Conclusions Targeted referral for individualised cardiometabolic interventions can lead to clinically significant improvement in cardiometabolic outcomes, providing a cause for therapeutic optimism when approaching physical health in people with SMI.
C1 [Esh, Nicole] Melbourne Hlth, North Western Mental Hlth, 300 Grattan St, Parkville, Vic 3050, Australia.
   [Michael, Sarah; Samaras, Katherine] St Vincents Hlth Network Sydney, Darlinghurst, NSW, Australia.
   [Michael, Sarah] Univ New South Wales, Sch Clin Med, Discipline Psychiat & Mental Hlth, Sydney, NSW, Australia.
   [Paetzholdt, Jonathan; Samaras, Katherine] St Vincents Clin, Australian Ctr Metab Hlth, Darlinghurst, NSW, Australia.
   [Samaras, Katherine] Garvan Inst Med Res, Darlinghurst, NSW, Australia.
C3 University of New South Wales Sydney; St Vincent's Clinic; Garvan
   Institute of Medical Research
RP Esh, N (corresponding author), Melbourne Hlth, North Western Mental Hlth, 300 Grattan St, Parkville, Vic 3050, Australia.
EM nicole.esh@mh.org.au
OI Esh, Nicole/0000-0002-8624-246X
CR [Anonymous], 2000, PRACTICAL GUIDE IDEN
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NR 30
TC 0
Z9 0
U1 0
U2 0
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1039-8562
EI 1440-1665
J9 AUSTRALAS PSYCHIATRY
JI Australas. Psychiatry
PD OCT
PY 2023
VL 31
IS 5
BP 678
EP 684
DI 10.1177/10398562231190781
EA JUL 2023
PG 7
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA IZ5J1
UT WOS:001037135800001
PM 37491945
DA 2025-06-11
ER

PT J
AU Zembura, M
   Matusik, P
AF Zembura, Marcela
   Matusik, Pawel
TI Sarcopenic Obesity in Children and Adolescents: A Systematic Review
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Review
DE sarcopenia; obesity; muscle mass; muscle strength; children; adolescents
ID SKELETAL-MUSCLE MASS; NUTRITION EXAMINATION SURVEY; KOREA
   NATIONAL-HEALTH; BODY-COMPOSITION; CARDIOMETABOLIC RISK; METABOLIC
   SYNDROME; LIVER; ASSOCIATION; PREVALENCE; CHILDHOOD
AB Sarcopenic obesity (SO) is defined as co-occurrence of increased fat mass and sarcopenia and may predict adverse health outcomes in the pediatric population. However, the prevalence of SO and its association with adverse health outcomes have not been well defined in children and adolescents. We systematically reviewed data on the SO definition, prevalence, and adverse outcomes in the pediatric population. A total of 18 articles retrieved from PubMed or Web of Science databases were included. Overall, there was a wide heterogeneity in the methods and thresholds used to define SO. The prevalence of SO ranged from 5.66% to 69.7% in girls, with a range between 7.2% and 81.3% in boys. Of the 8 studies that evaluated outcomes related to SO, all showed a significant association of SO with cardiometabolic outcomes, non-alcoholic fatty liver disease (NAFLD) severity, inflammation, and mental health. In conclusion, this review found that SO is highly prevalent in children and adolescents and is associated with various adverse health outcomes. Findings of this review highlight the need for the development of a consensus regarding definition, standardized evaluation methods, and age and gender thresholds for SO for different ethnicities in the pediatric population. Further studies are needed to understand the relationship between obesity and sarcopenia and SO impact on adverse health outcomes in children and adolescents.
C1 [Zembura, Marcela; Matusik, Pawel] Med Univ Silesiaia, Fac Med Sci Katowice, Chair Pediat & Pediat Endocrinol, Dept Pediat Pediat Obesity & Metab Bone Dis, Katowice, Poland.
C3 Medical University of Silesia
RP Zembura, M (corresponding author), Med Univ Silesiaia, Fac Med Sci Katowice, Chair Pediat & Pediat Endocrinol, Dept Pediat Pediat Obesity & Metab Bone Dis, Katowice, Poland.
EM marcela.zembura@gmail.com
RI Matusik, Pawel/AAL-9365-2020
OI Matusik, Pawel/0000-0002-8943-7051; Zembura, Marcela/0000-0003-2078-6330
CR [Anonymous], NIHSTUDY QUALITY ASS
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NR 57
TC 38
Z9 41
U1 1
U2 20
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD JUN 1
PY 2022
VL 13
AR 914740
DI 10.3389/fendo.2022.914740
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 2E1UM
UT WOS:000812018600001
PM 35721709
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Kim, CH
   Park, JY
   Kim, JY
   Choi, CS
   Kim, YI
   Chung, YE
   Lee, MS
   Hong, SK
   Lee, KU
AF Kim, CH
   Park, JY
   Kim, JY
   Choi, CS
   Kim, YI
   Chung, YE
   Lee, MS
   Hong, SK
   Lee, KU
TI Elevated serum ceruloplasmin levels in subjects with metabolic syndrome:
   A population-based study
SO METABOLISM-CLINICAL AND EXPERIMENTAL
LA English
DT Article
ID DEPENDENT DIABETES-MELLITUS; CULTURED ENDOTHELIAL-CELLS;
   LOW-DENSITY-LIPOPROTEIN; OXIDATIVE STRESS; CARDIOVASCULAR-DISEASE;
   INSULIN-RESISTANCE; COPPER DEFICIENCY; PROTEIN CERULOPLASMIN;
   MYOCARDIAL-INFARCTION; MISSING LINK
AB Serum ceruloplasmin was reported to be an independent risk factor for cardiovascular disease. We investigated whether serum ceruloplasmin level is elevated in subjects with metabolic syndrome (MS, insulin resistance syndrome) in a community-based population. A total 883 subjects over 40 years of age were studied among a population of the Chongup district, a rural area of South Korea. Serum ceruloplasmin levels were measured, and oral glucose tolerance tests were performed. Known cardiovascular risk factors, such as serum lipids, fasting insulin level, and urinary albumin excretion rate (UAER), were also measured. Serum ceruloplasmin levels in the subjects with MS (n = 167, 325 +/- 141 mg/L) were significantly higher than in those without MS (278 +/- 93 mg/L, P < .001). The mean ceruloplasmin level also increased as the glucose tolerance worsened (278 +/- 95 mg/L in normal glucose tolerance [NGT], 303 +/- 108 mg/L in impaired glucose regulation, and 328 +/- 148 mg/L in diabetes; P < .001). Serum ceruloplasmin level was positively correlated with age, fasting glucose, postload 2-hour glucose, total cholesterol, triglyceride, systolic blood pressure, diastolic blood pressure, and UAER and negatively with high-density lipoprotein (HDL)-cholesterol. In multiple regression analysis, serum ceruloplasmin level was independently associated with age, fasting glucose, triglyceride, HDL-cholesterol, and UAER. In conclusion, serum ceruloplasmin level is elevated in the subjects with MS, as well as in subjects with impaired glucose regulation or diabetes mellitus. In addition, serum ceruloplasmin level is associated with various cardiovascular risk factors. These results suggest that elevated serum ceruloplasmin level can be a marker for metabolic stresses associated with MS. Copyright 2002, Elsevier Science (USA). All rights reserved.
C1 Univ Ulsan, Coll Med, Dept Internal Med & Prevent Med, Seoul, South Korea.
   Soonchunhyang Univ, Dept Internal Med, Seoul, South Korea.
   Hallym Univ, Dept Internal Med, Seoul, South Korea.
C3 University of Ulsan; Soonchunhyang University; Hallym University
RP Asan Med Ctr, Dept Internal Med, Song Pa POB 145, Seoul 138600, South Korea.
RI MIN, B. I./U-3364-2017; Kim, Su Hyun/JPY-2079-2023; Lee,
   Myung/C-9606-2011
OI Kim, Chul-Hee/0000-0002-1911-138X
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NR 43
TC 43
Z9 52
U1 0
U2 4
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0026-0495
EI 1532-8600
J9 METABOLISM
JI Metab.-Clin. Exp.
PD JUL
PY 2002
VL 51
IS 7
BP 838
EP 842
DI 10.1053/meta.2002.33348
PG 5
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 569AY
UT WOS:000176578200006
PM 12077727
DA 2025-06-11
ER

PT J
AU Dornellas, APS
   Boldarine, VT
   Pedroso, AP
   Carvalho, LOT
   de andrade, IS
   Vulcani-Freitas, TM
   dos Santos, CCC
   do Nascimento, CMDO
   Oyama, LM
   Ribeiro, EB
AF Dornellas, Ana P. S.
   Boldarine, Valter T.
   Pedroso, Amanda P.
   Carvalho, Lorenza O. T.
   de andrade, Iracema S.
   Vulcani-Freitas, Tania M.
   dos Santos, Carla C. C.
   da Penha Oller do Nascimento, Claudia M.
   Oyama, Lila M.
   Ribeiro, Eliane B.
TI High-Fat Feeding Improves Anxiety-Type Behavior Induced by Ovariectomy
   in Rats
SO FRONTIERS IN NEUROSCIENCE
LA English
DT Article
DE hypothalamus; hippocampus; serotonin; lard; fish-oil; neuropeptides
ID CART MESSENGER-RNA; HIPPOCAMPAL NEUROGENESIS; SEROTONIN TRANSPORTER;
   POSTMENOPAUSAL WOMEN; METABOLIC SYNDROME; SEX-DIFFERENCES; ENRICHED
   DIET; DEPRESSION; STRESS; EXPRESSION
AB Menopause-induced changes may include increased incidence of both depression/anxiety and obesity. We hypothesized that behavioral changes that may develop after ovarian failure could be related to neurochemical and metabolic aspects affected by this condition and that high-fat intake may influence these associations. The present study investigated in rats the effects of ovariectomy, either alone or combined with high-fat diets enriched with either lard or fish-oil, on metabolic, behavioral and monoaminergic statuses, and on gene expression of neuropeptides and receptors involved in energy balance and mood regulation. Female rats had their ovaries removed and received either standard chow (OvxC) or high-fat diets enriched with either lard (OvxL) or fish-oil (OvxF) for 8 weeks. The Sham group received only chow diet. Ovariectomy increased feed efficiency and body weight gain and impaired glucose homeostasis and serotonin-induced hypophagia, effects either maintained or even accentuated by the lard diet but counteracted by the fish diet. The OvxL group developed obesity and hyperleptinemia. Regarding components of hypothalamic serotonergic system, both ovariectomy alone or combined with the fish diet increased 5-HT2C expression while the lard diet reduced 5-HT1B mRNA. Ovariectomy increased the anxiety index, as derived from the elevated plus maze test, while both high-fat groups showed normalization of this index. In the forced swimming test, ovariectomy allied to high-lard diet, but not to fish-oil diet, reduced the latency to immobility, indicating vulnerability to a depressive-like state. Linear regression analysis showed hippocampal AgRP to be negatively associated with the anxiety index and hypothalamic AgRP to be positively associated with the latency to immobility. These AgRp gene expression associations are indicative of a beneficial involvement of this neuropeptide on both depression and anxiety measures. The present findings demonstrate metabolic, neurochemical and behavioral alterations after ovaries removal and highlight a positive effect of high-fat feeding on the anxiety-like behavior shown by ovariectomized animals. Since the polyunsaturated omega-3 intake (fish diet), unlike the saturated fat intake (lard diet), failed to induce deleterious metabolic or neurochemical consequences, further studies are needed focusing on the potential of this dietary component as an adjuvant anxiolytic agent after menopause.
C1 [Dornellas, Ana P. S.; Boldarine, Valter T.; Pedroso, Amanda P.; Carvalho, Lorenza O. T.; de andrade, Iracema S.; Vulcani-Freitas, Tania M.; dos Santos, Carla C. C.; da Penha Oller do Nascimento, Claudia M.; Oyama, Lila M.; Ribeiro, Eliane B.] Univ Fed Sao Paulo, Physiol Dept, Escola Paulista Med, Sao Paulo, Brazil.
C3 Universidade Federal de Sao Paulo (UNIFESP)
RP Ribeiro, EB (corresponding author), Univ Fed Sao Paulo, Physiol Dept, Escola Paulista Med, Sao Paulo, Brazil.
EM eliane.beraldi@gmail.com
RI Ribeiro, Eliane/C-8124-2012; do Nascimento, Claudia/T-4151-2019; Oyama,
   Lila/B-7609-2012; Pedroso, Amanda/A-2310-2017; Boldarine,
   Valter/AAC-9086-2020
OI Segantine Dornellas, Ana Paula/0000-0001-8342-7402; Pedroso, Amanda
   Paula/0000-0001-7088-0187
FU State of Sao Paulo Research Foundation (FAPESP, Brazil); National
   Council for Scientific and Technological Development (CNPq, Brazil);
   Coordination for the Improvement of Higher Education Personnel (Capes,
   Brazil)
FX This study was supported by grants from: the State of Sao Paulo Research
   Foundation (FAPESP, Brazil), the National Council for Scientific and
   Technological Development (CNPq, Brazil), and the Coordination for the
   Improvement of Higher Education Personnel (Capes, Brazil).
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NR 86
TC 36
Z9 38
U1 0
U2 14
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1662-453X
J9 FRONT NEUROSCI-SWITZ
JI Front. Neurosci.
PD SEP 3
PY 2018
VL 12
AR 557
DI 10.3389/fnins.2018.00557
PG 13
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA GS3HS
UT WOS:000443481800001
PM 30233288
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Jeffery, AN
   Hyland, ME
   Hosking, J
   Wilkin, TJ
AF Jeffery, Alison N.
   Hyland, Michael E.
   Hosking, Joanne
   Wilkin, Terence J.
TI Mood and its association with metabolic health in adolescents: a
   longitudinal study, EarlyBird 65
SO PEDIATRIC DIABETES
LA English
DT Article
DE child; insulin resistance; longitudinal study; mood; weight perception
ID BODY-MASS INDEX; DEPRESSIVE SYMPTOMS; INSULIN-RESISTANCE; NEGATIVE
   AFFECT; DIABETES-MELLITUS; PHYSIOLOGICAL HYPERAROUSAL;
   GENDER-DIFFERENCES; TRIPARTITE MODEL; POSITIVE AFFECT; RISK-FACTORS
AB BackgroundMood comprises two main traits-positive and negative affect, both associated with depression and anxiety. Studies in children have linked depression with obesity, but the association with metabolic health is unclear.
   ObjectiveTo explore the relationship between mood and metabolic health in adolescents.
   MethodsWe studied 208 healthy children (115 boys) enrolled in the longitudinal EarlyBird Diabetes Study, and reviewed at 7 and 16yr. Participants completed the Positive Affect and Negative Affect Schedule-Child Form (PANAS-C) at 16yr to assess positive and negative affect, together representing mood. Measures at 7 and 16yr: body mass index (BMI), fat (%; dual energy X-ray absorptiometry), physical activity (accelerometer), metabolic risk z-score comprising homeostasis model assessment-insulin resistance (HOMA-IR), triglycerides, total cholesterol/high density lipoprotein (HDL) ratio and blood pressure. Pubertal development was determined by age at peak height velocity.
   ResultsPositive affect was higher in boys than girls, (50 vs. 46, p=0.001), negative affect higher in girls than boys (26 vs. 22, p<0.001). Those with lower mood were fatter (r=-0.24, p<0.001), had higher HOMA-IR (r=-0.12, p=0.05), higher cholesterol:HDL ratio (r=-0.14, p=0.02), were less active (r=0.20, p=0.003) and had earlier pubertal development (r=0.19, p=0.004). Inverse associations between mood and metabolic risk z-score and change in metabolic risk z-score 7-16yr (=-0.26, p=0.006, and -0.40, p=0.004, respectively) were independent of adiposity, physical activity and puberty and sex.
   ConclusionsLow mood in healthy children is associated with poorer metabolic health independently of adiposity. These findings may have implications for the physical and mental health of contemporary youngsters, given their increasing obesity and cardiometabolic risk.
C1 [Jeffery, Alison N.; Hosking, Joanne] Univ Plymouth, Peninsula Sch Med, Inst Translat & Stratified Med, Plymouth PL4 8AA, Devon, England.
   [Jeffery, Alison N.; Hosking, Joanne] Univ Plymouth, Peninsula Sch Dent, Inst Translat & Stratified Med, Plymouth PL4 8AA, Devon, England.
   [Hyland, Michael E.] Univ Plymouth, Dept Psychol, Plymouth PL4 8AA, Devon, England.
   [Wilkin, Terence J.] Univ Exeter, Sch Med, Inst Hlth & Social Res, Exeter, Devon, England.
C3 University of Plymouth; University of Plymouth; University of Plymouth;
   University of Exeter
RP Jeffery, AN (corresponding author), Univ Med, Derriford Hosp, Level 7, Plymouth PL6 8DH, Devon, England.
EM alison.jeffery@plymouth.ac.uk
OI Jeffery, Alison/0000-0001-7539-5957; Hyland, Michael/0000-0003-3879-0469
FU Bright Futures Trust; BUPA Foundation; Peninsula Foundation; Kirby-Laing
   Trust; Early Bird Diabetes Trust
FX Bright Futures Trust, the BUPA Foundation, the Peninsula Foundation,
   Kirby-Laing Trust and Early Bird Diabetes Trust.
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NR 52
TC 16
Z9 17
U1 1
U2 17
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1399-543X
EI 1399-5448
J9 PEDIATR DIABETES
JI Pediatr. Diabetes
PD DEC
PY 2014
VL 15
IS 8
BP 599
EP 605
DI 10.1111/pedi.12125
PG 7
WC Endocrinology & Metabolism; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Pediatrics
GA AT6FU
UT WOS:000345035600007
PM 24552539
DA 2025-06-11
ER

PT J
AU Park, S
   Kim, CG
   Kim, Y
AF Park, Seungmi
   Kim, Chul-Gyu
   Kim, Youngji
TI Comparison of metabolic syndrome and related factors in married
   pre-menopausal white- and blue-collar woman
SO ARCHIVES OF ENVIRONMENTAL & OCCUPATIONAL HEALTH
LA English
DT Article
DE Blue collar; menopause; metabolic syndrome; white collar; women
ID KOREAN NATIONAL-HEALTH; LIFE-STYLE FACTORS; ASSOCIATION; PREVALENCE;
   DEPRESSION; RISK
AB This study aimed to identify the prevalence and associated factors of metabolic syndrome in pre-menopausal married women with white-collar and blue-collar jobs. This study analyzed 4,447 women with jobs in the Korean National Health and Nutrition Examination Survey (2010-2018). The prevalence of metabolic syndrome was higher among blue-collar women (15.3%) than among white-collar women (10.5%). Age, family type, alcohol consumption, frequency of high-risk drinking, perceived health status, and body mass index (BMI) were significantly associated with metabolic syndrome in the white-collar (p < .05). Age, family type, frequency of eating out, and BMI were associated in the blue-collar (p < .05). Blue-collar women were more vulnerable to metabolic syndrome than white-collar ones. To prevent metabolic syndrome in pre-menopausal married women with jobs, lifestyle modifications such as mitigating obesity and reducing alcohol consumption with aging are necessary.
C1 [Park, Seungmi; Kim, Chul-Gyu] Chungbuk Natl Univ, Dept Nursing, Chungdae Ro 1, Cheongju 28644, Chungbuk, South Korea.
   [Kim, Youngji] Kongju Natl Univ, Coll Nursing & Hlth, Dept Nursing, Gongju Si, Chungcheongnam, South Korea.
C3 Chungbuk National University; Kongju National University
RP Kim, CG (corresponding author), Chungbuk Natl Univ, Dept Nursing, Chungdae Ro 1, Cheongju 28644, Chungbuk, South Korea.
EM cgkim@chungbuk.ac.kr
OI PARK, SEUNGMI/0000-0001-6156-1336
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NR 33
TC 4
Z9 4
U1 0
U2 1
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 1933-8244
EI 2154-4700
J9 ARCH ENVIRON OCCUP H
JI Arch. Environ. Occup. Health
PD SEP 9
PY 2022
VL 77
IS 9
BP 744
EP 754
DI 10.1080/19338244.2021.2007834
EA NOV 2021
PG 11
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA 4K9ZZ
UT WOS:000728471800001
PM 34882506
DA 2025-06-11
ER

PT J
AU Frías, A
   Martínez, B
   Palma, C
   Farriols, N
AF Frias, Alvaro
   Martinez, Barbara
   Palma, Carol
   Farriols, Nuria
TI Clinical impact of comorbid major depression in subjects with
   posttraumatic stress disorder: A review of the literature
SO NORDIC PSYCHOLOGY
LA English
DT Review
DE posttraumatic stress disorder; major depression; comorbidity; clinical
   impact; theoretical review
ID SUICIDAL IDEATION; GENDER-DIFFERENCES; CONTROLLED-TRIAL; PEACEKEEPING
   VETERANS; SERVICE UTILIZATION; PROLONGED EXPOSURE; METABOLIC SYNDROME;
   TREATMENT-SEEKING; SYMPTOM SEVERITY; PTSD COMORBIDITY
AB Nearly half of those with posttraumatic stress disorder (PTSD) have co-occurring major depressive disorder. Some etiopathogenic theories and treatments have been postulated for this comorbidity. However, there are no systematic reviews aimed at addressing the clinical impact of comorbid major depression in the PTSD profile. A comprehensive database search was performed from 1985 to February 2015. Overall, 94 studies fulfilled the inclusion criteria. The main evidence is described concerning several clinical criteria: PTSD symptoms and other psychopathology (suicide ideation/attempts or/and alcohol misuse), disability (quality of life and/or medical conditions), natural course, and treatment-related features (treatment seeking, response to treatment, and/or treatment compliance/preference). Overall, comorbid major depression tends to exert a deleterious role on the PTSD profile. This negative effect is mainly found regarding the symptomatology, disability, and natural course of PTSD. Methodological divergences are discussed with respect to inconsistent findings.
C1 [Frias, Alvaro; Palma, Carol; Farriols, Nuria] Univ Ramon Llull, FPCEE Blanquerna, Dept Psychol, Barcelona, Spain.
   [Frias, Alvaro; Martinez, Barbara; Palma, Carol; Farriols, Nuria] Consorci Sanit Maresme, Adult Outpatient Mental Hlth Ctr, Mataro, Spain.
C3 Universitat Ramon Llull
RP Frías, A (corresponding author), FPCEE Blanquerna, Cisterst 34, Barcelona 08022, Spain.
EM afrias@csdm.cat
RI Frias, Alvaro/AAB-6696-2020; HERNANDO, NÚRIA/L-3961-2017; Palma,
   Carol/G-6944-2017
OI Palma, Carol/0000-0001-5371-7417; Frias, Alvaro/0000-0002-7123-3819
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NR 124
TC 0
Z9 1
U1 1
U2 17
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 1901-2276
EI 1904-0016
J9 NORD PSYCHOL
JI Nord. Psychol.
PY 2016
VL 68
IS 4
BP 257
EP 271
DI 10.1080/19012276.2016.1162106
PG 15
WC Psychology, Multidisciplinary
WE Social Science Citation Index (SSCI)
SC Psychology
GA ED3JD
UT WOS:000388744500005
DA 2025-06-11
ER

PT J
AU Chen, JM
   Wang, X
   Dong, B
   Liu, C
   Zhao, JJ
   Dong, YG
   Liang, WH
   Huang, HL
AF Chen, Jiming
   Wang, Xing
   Dong, Bin
   Liu, Chen
   Zhao, Jingjing
   Dong, Yugang
   Liang, Weihao
   Huang, Huiling
TI Cardiac function and exercise capacity in patients with metabolic
   syndrome: A cross-sectional study
SO FRONTIERS IN CARDIOVASCULAR MEDICINE
LA English
DT Article
DE metabolic syndrome; cardiac function; exercise capacity; impedance
   electrocardiogram; exercise tolerance test
ID VENTRICULAR DIASTOLIC DYSFUNCTION; CARDIOPULMONARY; IMPACT; HEART
AB BackgroundMetabolic syndrome is a pre-diabetes condition that is associated with increased cardiovascular morbidity and mortality. We aimed to explore how exercise capacity, cardiac structure, and function were affected in patients with metabolic syndrome. MethodsOutpatients with echocardiography and exercise stress test combined with impedance cardiography (ETT + ICGG) results available from Nov 2018 to Oct 2020 were retrospectively enrolled. Echocardiographic, ETT + ICG profiles, and exercise performance were compared between patients with metabolic syndrome and the ones without. Sensitivity analyses were performed excluding patients without established coronary heart disease and further 1:1 paired for age and gender, respectively. Multiple linear regression was used to find out related predictors for maximal metabolic equivalents (METs). ResultsThree hundred and twenty-third patients were included, among whom 97 were diagnosed as metabolic syndrome. Compared to patients without metabolic syndrome, echocardiography showed that patients with metabolic syndrome had a significantly lower E/A ratio (p < 0.001). Besides, they have larger left atrium, larger right ventricle, and thicker interventricular septum (all p < 0.001), but similar left ventricular ejection fraction (P = 0.443). ICG showed that patients with metabolic syndrome had significantly higher stroke volume at rest and maximum (p < 0.001), higher left cardiac work index at rest and maximum (p = 0.005), higher systemic vascular resistance (SVR) at rest (p < 0.001), but similar SVI (p = 0.888). During exercise, patients with metabolic syndrome had lower maximal METs (p < 0.001), and a higher proportion suffering from ST-segment depression during exercise (p = 0.009). Sensitivity analyses yielded similar results. As for the linear regression model, 6 independent variables (systolic blood pressure, BMI, E/A ratio, the height of O wave, the peak value of LCWi, and the baseline of SVR) had statistically significant effects on the maximal METs tested in exercise (R = 0.525, R-2 = 0.246, P < 0.001). ConclusionPatients with metabolic syndrome had significant structural alteration, apparent overburden of left ventricular work index, pre-and afterload, which may be the main cause of impaired exercise tolerance.
C1 [Chen, Jiming; Wang, Xing; Dong, Bin; Liu, Chen; Zhao, Jingjing; Dong, Yugang; Liang, Weihao; Huang, Huiling] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Cardiol, Guangzhou, Peoples R China.
   [Wang, Xing; Dong, Bin; Liu, Chen; Zhao, Jingjing; Dong, Yugang; Liang, Weihao; Huang, Huiling] Sun Yat Sen Univ, Natl Hlth Comm NHC Key Lab Assisted Circulat, Guangzhou, Peoples R China.
C3 Sun Yat Sen University; Sun Yat Sen University
RP Liang, WH; Huang, HL (corresponding author), Sun Yat Sen Univ, Affiliated Hosp 1, Dept Cardiol, Guangzhou, Peoples R China.; Liang, WH; Huang, HL (corresponding author), Sun Yat Sen Univ, Natl Hlth Comm NHC Key Lab Assisted Circulat, Guangzhou, Peoples R China.
EM liangwh26@mail.sysu.edu.cn; hhling@mail.sysu.edu.cn
RI huang, huiling/JCN-5789-2023; Liang, Weihao/ABY-2001-2022
CR Alonso-Gómez AM, 2019, IJC HEART VASC, V22, P67, DOI 10.1016/j.ijcha.2018.12.010
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NR 30
TC 3
Z9 5
U1 0
U2 10
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2297-055X
J9 FRONT CARDIOVASC MED
JI Front. Cardiovasc. Med.
PD AUG 11
PY 2022
VL 9
AR 974802
DI 10.3389/fcvm.2022.974802
PG 10
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 3Z3WO
UT WOS:000844348300001
PM 36035938
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Zhang, L
   Zhou, Q
   Shao, LH
   Hu, XQ
   Wen, J
   Xia, J
AF Zhang, Li
   Zhou, Quan
   Shao, Li Hua
   Hu, Xue Qin
   Wen, Jun
   Xia, Jun
TI Association of metabolic syndrome with depression in US adults: A
   nationwide cross-sectional study using propensity score-based analysis
SO FRONTIERS IN PUBLIC HEALTH
LA English
DT Article
DE metabolic syndrome; depression; propensity score-based analysis;
   positive association; cross-sectional study
ID ANXIETY; SYMPTOMS; OBESITY; MORTALITY; SEVERITY; DISEASE
AB BackgroundThe association of metabolic syndrome (MetS) with depression has been previously reported; however, the results are ambiguous due to imbalanced confounding factors. Propensity score-based analysis is of great significance to minimize the impact of confounders in observational studies. Thus, the current study aimed to clarify the influence of MetS on depression incidence in the U.S. adult population by using propensity score (PS)-based analysis. MethodsData from 11,956 adults aged 20-85 years from the National Health and Nutrition Examination Survey (NHANES) database between 2005 and 2018 were utilized. Using 1:1 PS matching (PSM), the present cross-sectional study included 4,194 participants with and without MetS. A multivariate logistic regression model and three PS-based methods were applied to assess the actual association between MetS and depression incidence. Stratified analyses and interactions were performed based on age, sex, race, and components of MetS. ResultsAfter PSM, the risk of developing depression in patients with MetS increased by 40% in the PS-adjusted model (OR = 1.40, 95% confidence interval [CI]: 1.202-1.619, P < 0.001), and we could still observe a positive association in the fully adjusted model (OR = 1.37, 95% CI: 1.172-1.596, P < 0.001). Regarding the count of MetS components, having four and five conditions significantly elevated the risk of depression both in the PS-adjusted model (OR = 1.78, 95% CI: 1.341-2.016, P < 0.001 vs. OR = 2.11, 95% CI: 1.626-2.699, P < 0.001) and in the fully adjusted model (OR = 1.56, 95 CI%: 1.264-1.933, P < 0.001 vs. OR = 1.90, 95% CI: 1.458-2.486, P < 0.001). In addition, an elevation in MetS component count was associated with a significant linear elevation in the mean score of PHQ-9 (F =2.8356, P < 0.001). In the sensitivity analysis, similar conclusions were reached for both the original and weighted cohorts. Further interaction analysis revealed a clear gender-based difference in the association between MetS and depression incidence. ConclusionMetS exhibited the greatest influence on depression incidence in US adults, supporting the necessity of early detection and treatment of depressive symptoms in patients with MetS (or its components), particularly in female cases.
C1 [Zhang, Li; Shao, Li Hua; Wen, Jun] First Peoples Hosp Changde, Dept Neurol, Changde, Hunan, Peoples R China.
   [Zhou, Quan] First Peoples Hosp Changde, Dept Sci & Educ, Changde, Hunan, Peoples R China.
   [Hu, Xue Qin; Xia, Jun] First Peoples Hosp Changde, Dept Neurosurg, Changde, Hunan, Peoples R China.
RP Zhang, L (corresponding author), First Peoples Hosp Changde, Dept Neurol, Changde, Hunan, Peoples R China.
EM 34264274@qq.com
FU general program of Changde City Science Foundation [2020S014]
FX Funding This research was supported by grants from the general program
   of Changde City Science Foundation (2020S014).
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PG 9
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WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA 8X8AR
UT WOS:000932231700001
PM 36817886
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Clay, OJ
   Perkins, M
   Wallace, G
   Crowe, M
   Sawyer, P
   Brown, CJ
AF Clay, Olivio J.
   Perkins, Martinique
   Wallace, Gail
   Crowe, Michael
   Sawyer, Patricia
   Brown, Cynthia J.
TI Associations of Multimorbid Medical Conditions and Health-Related
   Quality of Life Among Older African American Men
SO JOURNALS OF GERONTOLOGY SERIES B-PSYCHOLOGICAL SCIENCES AND SOCIAL
   SCIENCES
LA English
DT Article
DE Life course and developmental change; Minority and diverse populations;
   Multimorbidity; Social determinants of health
ID LOW SOCIAL COHESION; METABOLIC SYNDROME; NEIGHBORHOOD DISADVANTAGE;
   CARDIOVASCULAR-DISEASE; SOCIOECONOMIC-STATUS; HEART-FAILURE; WHITE MEN;
   RISK; DISPARITIES; BEHAVIORS
AB Background: African American (AA) men battling multiple morbidities are tasked with managing the components of each condition and are at greater risk for adverse outcomes such as poor health-related quality of life (QOL), disability, and higher mortality rates.
   Method: Baseline data for AA men from the University of Alabama at Birmingham Study of Aging were utilized. Factor analysis was used to categorize medical conditions and create factor scores. Covariate-adjusted regression models assessed the relationships between categories of conditions and physical and mental health-related QOL as assessed by the SF-12.
   Results: The mean age of the sample of 247 AA men was 75.36 years and 49% lived in rural areas. Medical conditions fit into three factors: metabolic syndrome, kidney failure and neurological complications, and COPD and heart disease. Covariate-adjusted models revealed that low education, higher levels of income difficulty, and higher scores on metabolic syndrome and COPD and heart disease factors were associated with lower scores on physical health-related QOL, p's <.05. Higher levels of income difficulty were also associated with lower scores on mental health-related QOL.
   Discussion: These findings suggest the importance of examining clusters of comorbid medical conditions and their relationships to outcomes within older African American men.
C1 [Clay, Olivio J.; Perkins, Martinique; Crowe, Michael] Univ Alabama Birmingham, Dept Psychol, 415 Campbell Hall,1720 2nd Ave South, Birmingham, AL 35294 USA.
   [Wallace, Gail] Johns Hopkins Univ, Dept Mental Hlth, Baltimore, MD USA.
   [Sawyer, Patricia] Univ Alabama Birmingham, Dept Med, UAB Comprehens Ctr Hlth Aging, Birmingham, AL 35294 USA.
   [Brown, Cynthia J.] Birmingham Atlanta VA Geriatr Res Educ & Clin Ctr, Birmingham, AL USA.
   [Sawyer, Patricia; Brown, Cynthia J.] Univ Alabama Birmingham, Dept Med, Div Gerontol Geriatr & Palliat Care, Birmingham, AL 35294 USA.
C3 University of Alabama System; University of Alabama Birmingham; Johns
   Hopkins University; University of Alabama System; University of Alabama
   Birmingham; Geriatric Research Education & Clinical Center; University
   of Alabama System; University of Alabama Birmingham
RP Clay, OJ (corresponding author), Univ Alabama Birmingham, Dept Psychol, 415 Campbell Hall,1720 2nd Ave South, Birmingham, AL 35294 USA.
EM oclay@uab.edu
RI Clay, Olivio/AAF-8952-2020
OI Crowe, Michael/0000-0001-7736-4441; Clay, Olivio/0000-0002-7529-6120;
   Brown, Cynthia J/0000-0002-1629-5507
FU National Institute on Aging at the National Institutes of Health [R01
   AG015062, P30AG031054, 3P30AG031054-02S1]; UAB Mid-South
   Transdisciplinary Collaborative Center for Health Disparities, an NIH,
   National Institute on Minority Health and Health Disparities
   [U54MD008176]
FX This work was supported by the National Institute on Aging at the
   National Institutes of Health awards R01 AG015062 (UAB Study of Aging),
   P30AG031054 (Deep South RCMAR), and 3P30AG031054-02S1 (Research
   Supplement to Promote Diversity in Health Related Research). Additional
   funding was provided by the UAB Mid-South Transdisciplinary
   Collaborative Center for Health Disparities, an NIH, National Institute
   on Minority Health and Health Disparities funded initiative
   (U54MD008176). The content is solely the responsibility of the authors
   and does not necessarily represent the official views of the National
   Institutes of Health.
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NR 45
TC 19
Z9 20
U1 0
U2 13
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1079-5014
EI 1758-5368
J9 J GERONTOL B-PSYCHOL
JI J. Gerontol. Ser. B-Psychol. Sci. Soc. Sci.
PD MAR
PY 2018
VL 73
IS 2
SI SI
BP 258
EP 266
DI 10.1093/geronb/gbx090
PG 9
WC Geriatrics & Gerontology; Gerontology; Psychology; Psychology,
   Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Psychology
GA FT1CO
UT WOS:000422872000009
PM 28658936
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Fujita, T
AF Fujita, Toshiro
TI Aldosterone in salt-sensitive hypertension and metabolic syndrome
SO JOURNAL OF MOLECULAR MEDICINE-JMM
LA English
DT Review
DE aldosterone; oxidative stress; salt; hypertension; proteinuria;
   metabolic syndrome
ID ANGIOTENSIN-II; INSULIN-RESISTANCE; BLOOD-PRESSURE; OXIDATIVE STRESS;
   SODIUM; RECEPTOR; RATS; BLOCKADE; NEPHROPATHY; EXCRETION
AB Metabolic syndrome, which is caused by obesity, is now a global pandemic. Metabolic syndrome is an aggregation of hypertension, diabetes and dyslipidaemia. Insulin resistance is a key factor in the development of these components of metabolic syndrome. Concerning the mechanism for the development of hypertension in metabolic syndrome, the lack of insulin resistance in the kidney increases sodium reabsorption by hyperinsulinaemia, leading to sodium retention in the body, and resultant salt-sensitive hypertension. Moreover, hyperaldosteronism, which is caused by adipocyte-derived aldosterone-releasing factors, induces not only salt-sensitive hypertension, but also proteinuria in obese hypertensive rats. Salt loading markedly aggravates proteinuria and induces cardiac diastolic dysfunction in obese hypertensive rats, suggesting that salt and aldosterone exert unfavourable synergistic actions on the cardiovascular system, possibly through the overproduction of oxidative stress. In turn, reactive oxygen species (ROS), which are induced by adipokines such as tumour necrosis factor-alpha, non-esterified fatty acids, angiotensinogen etc., can activate the mineralocorticoid (MR) receptor, in an aldosterone-independent fashion. Therefore, aldosterone/MR activation plays a key role not only in the development of salt-sensitive hypertension, but also in cardiovascular injury in metabolic syndrome, possibly through its function as a feed-forward system.
C1 Univ Tokyo, Dept Nephrol & Endocrinol, Bunkyo Ku, Tokyo 1138655, Japan.
C3 University of Tokyo
RP Fujita, T (corresponding author), Univ Tokyo, Dept Nephrol & Endocrinol, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1138655, Japan.
EM fujita-dis@h.u-tokyo.ac.jp
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   Zheng YN, 2005, J AM SOC NEPHROL, V16, P2288, DOI 10.1681/ASN.2005020193
NR 34
TC 63
Z9 70
U1 0
U2 5
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0946-2716
EI 1432-1440
J9 J MOL MED
JI J. Mol. Med.
PD JUN
PY 2008
VL 86
IS 6
BP 729
EP 734
DI 10.1007/s00109-008-0343-1
PG 6
WC Genetics & Heredity; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Genetics & Heredity; Research & Experimental Medicine
GA 299HO
UT WOS:000255746900021
PM 18437332
DA 2025-06-11
ER

PT J
AU Sun, J
   Buys, N
   Jayasinghe, R
AF Sun, Jing
   Buys, Nicholas
   Jayasinghe, Rohan
TI Effects of community-based meditative Tai Chi programme on improving
   quality of life, physical and mental health in chronic heart-failure
   participants
SO AGING & MENTAL HEALTH
LA English
DT Article
DE mind-body meditation approach; heart failure; Tai Chi; quality of life;
   body mass index; blood pressure
ID EXERCISE; DISEASE; STRESS; RISK; FOUNDATION; RESILIENCE; AUSTRALIA;
   MORTALITY; ANXIETY; BURDEN
AB Background: There is increasing evidence that coronary heart disease is linked with a number of psychosocial risk factors and biophysiological risk factors such as metabolic syndrome. This study aimed to compare Tai Chi programme heart-failure participants between the pre-intervention phase and six month after intervention time in health-related quality of life (HRQoL), including physical health, role-physical, bodily pain, general health, vitality, social functioning, role-emotional and mental health. In addition, the difference between pre-intervention and post-intervention time in psychological distress and resilience, body mass index (BMI), systolic blood pressure (SBP) and diastolic blood pressure (DBP) were compared.Methods: A prospective intervention study was conducted in 2012 to evaluate the effectiveness of a community-based meditation Tai Chi intervention programme to improve heart-failure patients' health. Measures included the Short-Form 12 Health Survey (SF-12), General Health Questionnaire (GHQ30), resilience scale, BMI, blood pressure and waist circumference. Univariate analysis of variance was used to compare the difference between pre- and post-intervention in Tai Chi participants.Results: Outcomes differed in significance and magnitude across four HRQoL measures, psychological distress and resilience between the pre- and post-intervention time in heart-failure patients who participated in the Tai Chi exercise. The participants in the post-intervention time also reduced BMI, SBP, and waist circumference.Conclusions: Regular and more than six months Tai Chi exercises had a beneficial effect to HRQoL, reducing psychological distress, promoting resilience, and reducing the BMI and blood pressure level in heart-failure patients.
C1 [Sun, Jing; Buys, Nicholas; Jayasinghe, Rohan] Griffith Univ, Griffith Hlth Inst, Nathan, Qld 4111, Australia.
   [Jayasinghe, Rohan] Queensland Hlth, Cardiac Serv, Gold Coast Hlth Dist, Brisbane, Qld, Australia.
   [Jayasinghe, Rohan] Queensland Hlth, Dept Cardiol, Gold Coast Hlth Dist, Brisbane, Qld, Australia.
   [Sun, Jing] Soochow Univ, Coll Med, Sch Publ Hlth, Suzhou, Peoples R China.
   [Sun, Jing] Jiangsu Prov Ctr Dis Control & Prevent, Nanjing, Jiangsu, Peoples R China.
   [Sun, Jing] Changshu Ctr Dis Control & Prevent, Chang Shu, Peoples R China.
C3 Menzies Health Institute Queensland; Griffith University; Queensland
   Health; Queensland Health; Soochow University - China; Jiangsu
   Provincial Center for Disease Control & Prevention
RP Sun, J (corresponding author), Griffith Univ, Griffith Hlth Inst, Nathan, Qld 4111, Australia.
EM j.sun@griffith.edu.au
RI Sun, Jing/AAS-1582-2020; Buys, Nicholas/AAT-3925-2020
OI Sun, Jing/0000-0002-0097-2438; Buys, Nicholas/0000-0002-4780-8088
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NR 42
TC 37
Z9 41
U1 0
U2 36
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 1360-7863
EI 1364-6915
J9 AGING MENT HEALTH
JI Aging Ment. Health
PD APR 3
PY 2014
VL 18
IS 3
BP 289
EP 295
DI 10.1080/13607863.2013.875120
PG 7
WC Geriatrics & Gerontology; Gerontology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Psychiatry
GA AB5YK
UT WOS:000331864400004
PM 24404785
DA 2025-06-11
ER

PT J
AU Morgan, J
   Bauer, S
   Whitsel, A
   Combs, CA
AF Morgan, Jamie
   Bauer, Samuel
   Whitsel, Amy
   Combs, C. Andrew
CA Soc Maternal-Fetal Med SMFM
   Patient Safety Quality Comm
TI Society for Maternal-Fetal Medicine Special Statement: Postpartum visit
   checklists for normal pregnancy and complicated pregnancy
SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
LA English
DT Article
DE anemia; cardiovascular disease; depression; fetal growth restriction;
   fourth trimester; metabolic syndrome; obesity; preeclampsia; pulmonary
   disease; rheumatologic disorders
ID UNITED-STATES; MORTALITY; RISK; WOMEN
AB Rising maternal morbidity and mortality rates, widening healthcare disparities, and increasing focus on cardiometabolic risk modification in at-risk patients have together catalyzed a shift in the postpartum care paradigm. What was once a single office visit in the 6 weeks after delivery is now being reimagined as a continuum of care that transitions patients from pregnancy to lifelong health optimization. However, this shift in postpartum care also comes with increased visit complexity and additional provider burden, particularly when patients have had significant pregnancy complications or have chronic diseases. To ensure that the comprehensive needs of both healthy and medically complex people are consistently met under this revised postpartum care paradigm, a postpartum visit checklist for uncomplicated postpartum patients and another checklist for those with major medical or obstetrical morbidities are presented. These checklists are designed to ensure that essential elements of physical and mental wellbeing are routinely considered, that adequate follow-up or specialty referrals are made, and that relevant future health risks are appropriately reviewed and discussed.
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   American Coll Obstetricians, 2018, OBSTET GYNECOL, V132, pE208, DOI 10.1097/AOG.0000000000002927
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NR 32
TC 3
Z9 3
U1 1
U2 2
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0002-9378
EI 1097-6868
J9 AM J OBSTET GYNECOL
JI Am. J. Obstet. Gynecol.
PD OCT
PY 2022
VL 227
IS 4
BP B2
EP B8
DI 10.1016/j.ajog.2022.06.007
PG 7
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA 6Q4KN
UT WOS:000891582600001
PM 35691408
DA 2025-06-11
ER

PT J
AU Dziegielewska-Gesiak, S
AF Dziegielewska-Gesiak, Sylwia
TI Metabolic Syndrome in an Aging Society - Role of Oxidant-Antioxidant
   Imbalance and Inflammation Markers in Disentangling Atherosclerosis
SO CLINICAL INTERVENTIONS IN AGING
LA English
DT Review
DE atherosclerosis; metabolic syndrome; aging; oxidant-antioxidant balance;
   inflammation
ID TYPE-2 DIABETES-MELLITUS; NF-KAPPA-B; OXIDATIVE STRESS;
   INSULIN-RESISTANCE; CARDIOVASCULAR RISK; WAIST CIRCUMFERENCE;
   NITRIC-OXIDE; DOUBLE-BLIND; ENDOTHELIAL DYSFUNCTION; BLOOD-PRESSURE
AB Introduction: The prevalence of metabolic syndrome among the elderly population is growing. The elements of metabolic syndrome in an aging society are currently being researched. Atherosclerosis is a slow process in which the first symptoms may be observed after many years. The mechanisms underlying the progression of atherosclerosis are oxidative stress and inflammation. Inflammation and oxidative stress are associated with the increased incidence of metabolic syndrome. Taking the above into consideration, metabolic syndrome is thought to be a clinical equivalent of atherosclerosis.
   Aim: The aim of this paper is to review the impact of the interplay of oxidant-antioxidant and inflammation markers in metabolic syndrome in general as well as its components in the pathophysiology which underlies development of atherosclerosis in elderly individuals.
   Methods: A systematic scan of online resources designed for elderly (>= 65 years) published from 2005 to the end of 2020 were reviewed. This was supplemented with grey literature and then all resources were narratively analyzed. The analysis included the following terms: "atherosclerosis or metabolic syndrome" and "oxidative stress or inflammation" and "elderly" to find reports of atherosclerotic disease from asymptomatic to life-threatening among the elderly population with metabolic syndrome.
   Results: The work summarizes articles that were applicable to this study, including systematic reviews, qualitative studies and opinion pieces. Current knowledge focuses on monitoring the inflammation and oxidant-antioxidant imbalance in disentangling atherosclerosis in patients diagnosed with metabolic syndrome. The population-based studies described inflammation, increased oxidative stress and weak antioxidant defense systems as the mechanisms underlying atherosclerosis development. Moreover, there are discussions that these targets could potentially be a point of intervention to reduce the development of atherosclerosis in the elderly, especially those with altered glucose and lipid metabolism. Specific markers may be used as an approach for the prevention and lifestyle modification of atherosclerotic disease in such population.
   Conclusion: Metabolic syndrome and its components are important contributors in the progression of atherosclerotic disease in the elderly population but constant efforts should be made to broaden our knowledge of elderly groups who are the most susceptible for the development of atherosclerosis complications.
C1 [Dziegielewska-Gesiak, Sylwia] Med Univ Silesia, Dept Internal Med, Piekarska 18 Str, PL-44902 Bytom, Poland.
C3 Medical University of Silesia
RP Dziegielewska-Gesiak, S (corresponding author), Med Univ Silesia, Dept Internal Med, Piekarska 18 Str, PL-44902 Bytom, Poland.
EM sgesiak@sum.edu.pl
RI Dzięgielewska-Gesiak, Sylwia/IYS-6186-2023
OI Dziegielewska-Gesiak, Sylwia/0000-0003-1019-5959
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NR 149
TC 23
Z9 24
U1 1
U2 21
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
EI 1178-1998
J9 CLIN INTERV AGING
JI Clin. Interv. Aging
PY 2021
VL 16
BP 1057
EP 1070
DI 10.2147/CIA.S306982
PG 14
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA TA8IP
UT WOS:000667489200001
PM 34135578
OA gold, Green Published
DA 2025-06-11
ER

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   Kucukakkas, Okan
   Yurdakul, Ozan Volkan
   Melikoglu, Meltem Alkan
   Aydin, Yildiray
   Ayhan, Fikriye Figen
   Bodur, Hatice
   Calis, Mustafa
   Capkin, Erhan
   Devrimsel, Gul
   Ecesoy, Hilal
   Hizmetli, Sami
   Kamanli, Ayhan
   Kutluk, Oznur
   Sen, Nesrin
   Sendur, Omer Faruk
   Tolu, Sena
   Toprak, Murat
   Tuncer, Tiraje
TI Impact of obesity on quality of life, psychological status, and disease
   activity in psoriatic arthritis: a multi-center study
SO RHEUMATOLOGY INTERNATIONAL
LA English
DT Article
DE Psoriatic arthritis; Obesity; Quality of life; Anxiety; Depression;
   Disease activity
ID HEALTH-ASSESSMENT QUESTIONNAIRE; RHEUMATOID-ARTHRITIS;
   ANKYLOSING-SPONDYLITIS; METABOLIC SYNDROME; DIABETES-MELLITUS; ANXIETY;
   RISK; COMORBIDITIES; DEPRESSION; PREVALENCE
AB This article aims to evaluate the possible effect of obesity on quality of life, psychological status, and other clinical variables in Psoriatic arthritis (PsA). PsA patients have been recruited by the Turkish League Against Rheumatism-Network from various centers in Turkey in this cross-sectional study. Patients with a body mass index (BMI) >= of 30 kg/m(2) were considered obese. Differences among patients with regard to obesity status were assessed with health-related quality of life measures (PsA Quality of Life Questionnaire [PsAQoL]), psychological status (Hospital Anxiety and Depression Scale [HADS]), and disease activity parameters (the Disease Activity index for PSoriatic Arthritis [DAPSA], Disease Activity Score 28-C-reactive protein [DAS28-CRP], Bath Ankylosing Spondylitis Disease Activity Index [BASDAI], Psoriasis Area and Severity Index [PASI]), physical functions (Ankylosing Spondylitis Functional Index [BASFI], Health Assessment Questionnaire [HAQ], and Health Assessment Questionnaire for the spondyloarthropathies [HAQ-S]). Pain was assessed using visual analog scale of pain (VAS-P), and fatigue was evaluated using visual analog scale of fatigue (VAS-F) and Functional Assessment of Chronic Illness Therapy (FACIT). A total of 1033 patients with PsA, 650 (62.9%) non-obese and 383 (37.1%) obese were included in the study. The PsAQoL, HADS-Anxiety, HADS-Depression, DAPSA, DAS28-CRP, BASDAI, BASFI, HAQ and HAQ-S scores of the obese group were higher than the non-obese group (p < 0.05). VAS-P and PASI scores were similar between group of patients with and without obesity. Obese patients had higher median scores of VAS-F and FACIT than non-obese patients (p < 0.05). Linear regression analysis showed that BMI affects the quality of life, depression, and disease activity. Consequently, obesity has significant associations with higher disease activity, lower QoL, risk of anxiety, depression, and fatigue. Therefore, obesity should also be taken into account in the management of PsA patients.
C1 [Gok, Kevser] Ankara City Hosp, Rheumatol Clin, Ankara, Turkey.
   [Nas, Kemal; Tekeoglu, Ibrahim; Kamanli, Ayhan] Sakarya Univ, Dept Phys Med & Rehabil, Div Rheumatol & Immunol, Sch Med, Sakarya, Turkey.
   [Sunar, Ismihan] Aydin State Hosp, Rheumatol Clin, Aydin, Turkey.
   [Keskin, Yasar; Kucukakkas, Okan; Yurdakul, Ozan Volkan] Bezmialem Vakif Univ, Dept Phys Med & Rehabil, Istanbul, Turkey.
   [Kilic, Erkan] Kanuni Training & Res Hosp, Rheumatol Clin, Trabzon, Turkey.
   [Sargin, Betul] Adnan Menderes Univ, Dept Phys Med & Rehabil, Div Rheumatol, Sch Med, Aydin, Turkey.
   [Kasman, Sevtap Acer; Duruoz, Mehmet Tuncay] Marmara Univ, Dept Phys Med & Rehabil, Div Rheumatol, Sch Med, Istanbul, Turkey.
   [Alkan, Hakan] Pamukkale Univ, Dept Phys Med & Rehabil, Sch Med, Denizli, Turkey.
   [Sahin, Nilay] Balikesir Univ, Dept Phys Med & Rehabil, Sch Med, Balikesir, Turkey.
   [Cengiz, Gizem; Calis, Mustafa] Erciyes Univ, Dept Phys Med & Rehabil, Div Rheumatol, Sch Med, Kayseri, Turkey.
   [Cuzdan, Nihan] Balikesir Ataturk City Hosp, Rheumatol Clin, Balikesir, Turkey.
   [Gezer, Ilknur Albayrak] Selcuk Univ, Dept Phys Med & Rehabil, Sch Med, Konya, Turkey.
   [Keskin, Dilek] Kirikkale Univ, Dept Phys Med & Rehabil, Sch Med, Kirikkale, Turkey.
   [Mulkoglu, Cevriye] Ankara Numune Training & Res Hosp, Dept Phys Med & Rehabil, Ankara, Turkey.
   [Resorlu, Hatice] Canakkale Onsekiz Mart Univ, Dept Phys Med & Rehabil, Sch Med, Canakkale, Turkey.
   [Bal, Ajda] Univ Hlth Sci Ankara, Dept Phys Med & Rehabil, Diskapi Yildirim Beyazit Training & Res Hosp, Ankara, Turkey.
   [Melikoglu, Meltem Alkan] Ataturk Univ, Dept Phys Med & Rehabil, Div Rheumatol, Sch Med, Erzurum, Turkey.
   [Aydin, Yildiray] Tekirdag Kapakli State Hosp, Dept Phys Med & Rehabil, Tekirdag, Turkey.
   [Ayhan, Fikriye Figen] Atilim Univ, Dept Phys Med & Rehabil, Med Sch, Ankara, Turkey.
   [Bodur, Hatice] Yildirim Beyazit Univ, Dept Phys Med & Rehabil, Sch Med, Ankara, Turkey.
   [Capkin, Erhan] Karadeniz Tech Univ, Dept Phys Med & Rehabil, Sch Med, Trabzon, Turkey.
   [Devrimsel, Gul] Recep Tayyip Erdogan Univ, Dept Phys Med & Rehabil, Sch Med, Rize, Turkey.
   [Ecesoy, Hilal] Necmettin Erbakan Univ, Dept Phys Med & Rehabil, Div Rheumatol, Meram Sch Med, Konya, Turkey.
   [Hizmetli, Sami] Cumhuriyet Univ, Dept Phys Med & Rehabil, Div Rheumatol, Sch Med, Sivas, Turkey.
   [Kutluk, Oznur] Antalya Training & Res Hosp, Rheumatol Clin, Antalya, Turkey.
   [Sen, Nesrin] Kartal Dr Lutfi Kirdar Training & Res Hosp, Rheumatol Clin, Istanbul, Turkey.
   [Sendur, Omer Faruk] Medicana Int Hosp, Dept Phys Med & Rehabil & Algol, Izmir, Turkey.
   [Tolu, Sena] Medipol Univ, Dept Phys Med & Rehabil, Sch Med, Istanbul, Turkey.
   [Toprak, Murat] Yuzuncu Yil Univ, Dept Phys Med & Rehabil, Sch Med, Van, Turkey.
   [Tuncer, Tiraje] Akdeniz Univ, Dept Phys Med & Rehabil, Div Rheumatol, Sch Med, Antalya, Turkey.
C3 City Hospital Ankara; Sakarya University; Aydin State Hospital;
   Bezmialem Vakif University; Trabzon Kanuni Training & Research Hospital;
   Adnan Menderes University; Marmara University; Pamukkale University;
   Balikesir University; Erciyes University; Selcuk University; Kirikkale
   University; Ankara Numune Training & Research Hospital; Canakkale
   Onsekiz Mart University; Diskapi Yildirim Beyazit Training & Research
   Hospital; Ataturk University; Atilim University; Ankara Yildirim Beyazit
   University; Karadeniz Technical University; Recep Tayyip Erdogan
   University; Necmettin Erbakan University; Cumhuriyet University; Antalya
   Training & Research Hospital; Istanbul Kartal Dr Lutfi Kirdar Training &
   Research Hospital; Medicana Hospital; Istanbul Medipol University;
   Yuzuncu Yil University; Akdeniz University
RP Gok, K (corresponding author), Ankara City Hosp, Rheumatol Clin, Ankara, Turkey.
EM kevserorhangok@gmail.com; kemalnas@yahoo.com; teke58@gmail.com;
   dr.ismihan@gmail.com; ykeskin42@hotmail.com; ekilic.md@hotmail.com;
   betulsargin83@hotmail.com; sevtap-acer@hotmail.com; alkangsc@yahoo.com;
   nilaysahin@gmail.com; gizemcng@outlook.com; nihancuzdan@hotmail.com;
   ilknurftr@gmail.com; drdilekkeskin@yahoo.com; drckaraca@hotmail.com;
   drresorlu@gmail.com; ajdabal@yahoo.com; tuncayduruoz@gmail.com;
   okan4494@yahoo.com; yurdakul_ozan@yahoo.com; mamelikoglu@gmail.com;
   yildiraydin_67@hotmail.com; figenardic@gmail.com; haticebodur@gmail.com;
   mcalis@erciyes.edu.tr; drcapkin@yahoo.com; g.devrimsel@hotmail.com;
   hllkocabas@yahoo.com; hizmetlis@gmail.com; akamanli@hotmail.com;
   oznurkutluk@gmail.com; sennes77@yahoo.com; ofsendur@gmail.com;
   dr.sena2005@gmail.com; dr.murattoprak@gmail.com; heratt@gmail.com
RI Alkan, Hakan/AAH-5910-2021; Devrimsel, Gul/HIZ-8461-2022; Cengiz,
   Gizem/AAN-2597-2021; Ecesoy, Hilal/AAK-4471-2021; Orhan,
   Kevser/GVR-9735-2022; Nas, Kemal/HSG-2378-2023; ŞAHİN,
   Nilay/GVU-6923-2022; TEKEOGLU, IBRAHIM/HTO-8999-2023; Keskin,
   Yasar/AAI-4634-2020; KAMANLI, AYHAN/AAC-9523-2022; KILIÇ,
   Erkan/AAW-5006-2020; Mülkoglu, Cevriye/ABJ-8720-2022; şen,
   nesrin/ABI-6368-2020; toprak, murat/AGL-9685-2022; capkin,
   erhan/D-6630-2015; Ayhan, Fikriye/O-4438-2014; Küçükakkaş,
   Okan/AAQ-2605-2020; Acer Kasman, Sevtap/GLS-5561-2022; Duruoz, Mehmet
   Tuncay/I-2307-2016; Yurdakul, Ozan Volkan/F-5266-2019; Alkan Melikoglu,
   Meltem/K-5695-2019
OI Sen, Nesrin/0000-0003-0966-0075; Acer Kasman,
   Sevtap/0000-0002-4805-0555; mulkoglu, cevriye/0000-0001-9113-3885;
   cengiz, gizem/0000-0002-0021-7002; Orhan, Kevser/0000-0001-8639-751X;
   TEKEOGLU, IBRAHIM/0000-0003-3395-7178; NAS, Kemal/0000-0002-5845-0851;
   alkan, hakan/0000-0001-8461-9131; Keskin, Yasar/0000-0003-4457-5917;
   Sunar, Ismihan/0000-0002-4435-5677; Duruoz, Mehmet
   Tuncay/0000-0003-3584-2788; Yurdakul, Ozan Volkan/0000-0003-4567-8133;
   Alkan Melikoglu, Meltem/0000-0001-7519-9470
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NR 54
TC 13
Z9 14
U1 2
U2 40
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0172-8172
EI 1437-160X
J9 RHEUMATOL INT
JI Rheumatol. Int.
PD APR
PY 2022
VL 42
IS 4
BP 659
EP 668
DI 10.1007/s00296-021-04971-8
EA AUG 2021
PG 10
WC Rheumatology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Rheumatology
GA ZX8IQ
UT WOS:000690697700003
PM 34453579
DA 2025-06-11
ER

PT J
AU Rohatgi, A
   Anand, SS
   Gadgil, M
   Gujral, UP
   Jain, SS
   Javed, Z
   Jha, M
   Joshi, PH
   Manubolu, VS
   Nasir, K
   Natarajan, P
   Pagidipati, N
   Palaniappan, L
   Patel, AP
   Satish, P
   Shah, NS
   Sharma, G
   Trivedi, MH
   Virani, SS
   Gulati, M
   Patel, J
AF Rohatgi, Anand
   Anand, Sonia S.
   Gadgil, Meghana
   Gujral, Unjali P.
   Jain, Sneha S.
   Javed, Zulqarnain
   Jha, Manish
   Joshi, Parag H.
   Manubolu, Venkat Sanjay
   Nasir, Khurram
   Natarajan, Pradeep
   Pagidipati, Neha
   Palaniappan, Latha
   Patel, Aniruddh P.
   Satish, Priyanka
   Shah, Nilay S.
   Sharma, Garima
   Trivedi, Madhukar H.
   Virani, Salim S.
   Gulati, Martha
   Patel, Jaideep
TI South Asians and cardiometabolic health: A framework for comprehensive
   care for the individual, community, and population-An American society
   for preventive cardiology clinical practice statement
SO AMERICAN JOURNAL OF PREVENTIVE CARDIOLOGY
LA English
DT Article
DE South Asian; Cardiometabolic; Prevention; Lifestyle; Diabetes; Coronary;
   Social determinants of health; Ethnic
ID COMPUTED-TOMOGRAPHY ANGIOGRAPHY; CORONARY-HEART-DISEASE; TYPE-2
   DIABETES-MELLITUS; CARDIOVASCULAR-DISEASE; MENTAL-HEALTH; RISK-FACTORS;
   MYOCARDIAL-INFARCTION; MEDICATION ADHERENCE; ARTERY CALCIUM; US
AB South Asians (SAs) represent an increasing proportion of North American populations and demonstrate excess cardiometabolic risk. Multiple factors likely contribute; however, much is not yet known about what leads to this excess risk. Diet composition, physical activity, and mental health are important lifestyle contributors. Specific adverse pregnancy outcomes are higher in SA women and represent an early opportunity for intervention. More broadly, comprehensive assessments of adiposity, diabetes, hypertension, dyslipidemia, coronary atherosclerosis via imaging, and genetic risk may improve detection and awareness among SAs and those treating SAs. At an individual level, culturally tailored preventive clinics may foster awareness and detection, leading to improved prevention and management of cardiometabolic risk. At a community and population level, assessments of the impact of social determinants, acculturation, and the environment may lead to broader initiatives to improve health in SAs. Lastly, supporting expanded investigation, policy, and other health and science measures at an institutional and societal level may lead to broad but impactful changes across the North American diaspora. In this clinical practice statement, we aim to provide a roadmap of the path forward in each of these domains for health care providers and health systems, community outreach groups, and stakeholders invested in investigation and policy to mitigate risk and empower SAs to lead healthy lives.
C1 [Rohatgi, Anand; Joshi, Parag H.] Univ Texas Southwestern Med Ctr, Dept Internal Med, Div Cardiol, Dallas, TX USA.
   [Anand, Sonia S.] McMaster Univ, Populat Hlth Res Inst, Dept Med, Hamilton, ON, Canada.
   [Gadgil, Meghana] Univ Calif San Francisco, Dept Med, Div Gen Internal Med, San Francisco, CA USA.
   [Gujral, Unjali P.] Rollins Sch Publ Hlth, Hubert Dept Global Hlth, Atlanta, GA USA.
   [Jain, Sneha S.] Stanford Univ, Div Cardiovasc Med, Stanford, CA USA.
   [Jain, Sneha S.] Stanford Univ, Cardiovasc Inst, Stanford, CA USA.
   [Javed, Zulqarnain] Houston Methodist Hosp, Dept Prevent Cardiol, Div Cardiol, Houston, TX USA.
   [Javed, Zulqarnain] Weill Cornell Med, New York Presbyterian Hosp, New York, NY USA.
   [Jha, Manish; Trivedi, Madhukar H.] Univ Texas Southwestern Med Ctr, Peter ODonnell Jr Brain Inst, Ctr Depress Res & Clin Care, Dept Psychiat, Dallas, TX USA.
   [Manubolu, Venkat Sanjay] Harbor Univ Calif, Los Angeles Med Ctr, Dept Internal Med, Div Cardiol, Torrance, CA USA.
   [Nasir, Khurram] Houston Methodist Res Inst, Ctr Cardiovasc Computat Hlth & Precis Med C3PH, Dept Cardiol, Houston, TX USA.
   [Natarajan, Pradeep; Patel, Aniruddh P.] Massachusetts Gen Hosp, Ctr Genom Med, Boston, MA USA.
   [Natarajan, Pradeep; Patel, Aniruddh P.] Massachusetts Gen Hosp, Dept Med, Div Cardiol, Boston, MA USA.
   [Natarajan, Pradeep; Patel, Aniruddh P.] Harvard Med Sch, Boston, MA USA.
   [Natarajan, Pradeep; Patel, Aniruddh P.] Broad Inst MIT & Harvard, Cardiovasc Dis Initiat, Cambridge, MA USA.
   [Pagidipati, Neha] Duke Clin Res Inst, Durham, NC USA.
   [Palaniappan, Latha] Stanford Univ, Dept Hlth Policy, Sch Med, Stanford, CA USA.
   [Satish, Priyanka] Univ Texas Austin, Ctr Cardiovasc Prevent, Dell Med Sch, Ascension Texas Cardiovasc, Austin, TX USA.
   [Shah, Nilay S.] Northwestern Univ, Dept Med Cardiol & Prevent Med, Feinberg Sch Med, Chicago, IL USA.
   [Sharma, Garima] Inova Hlth Syst, 1 Inova Schar Heart & Vasc, Falls Church, VA USA.
   [Sharma, Garima] Northwestern Univ, Div Cardiol 2, Chicago, IL USA.
   [Virani, Salim S.] Aga Khan Univ, Karachi, Pakistan.
   [Gulati, Martha] Cedars Sinai Smidt Heart Inst, Barbra Streisand Womens Heart Ctr, Los Angeles, CA USA.
   [Gulati, Martha] Baim Inst Clin Res, Boston, MA USA.
   [Patel, Jaideep] Ciccarone Ctr Prevent Cardiovasc Dis, South Asian Cardiovasc Hlth Initiat, Baltimore, MD USA.
   [Patel, Jaideep] Johns Hopkins Univ, Sch Med, Div Cardiol, Baltimore, MD USA.
C3 University of Texas System; University of Texas Southwestern Medical
   Center Dallas; Population Health Research Institute; McMaster
   University; University of California System; University of California
   San Francisco; Emory University; Rollins School Public Health; Stanford
   University; Stanford University; Houston Methodist; NewYork-Presbyterian
   Hospital; Cornell University; Weill Cornell Medicine; University of
   Texas System; University of Texas Southwestern Medical Center Dallas;
   University of California System; University of California Los Angeles;
   University of California Los Angeles Medical Center; Houston Methodist;
   Harvard University; Harvard University Medical Affiliates; Massachusetts
   General Hospital; Harvard University; Harvard University Medical
   Affiliates; Massachusetts General Hospital; Harvard University; Harvard
   Medical School; Harvard University; Massachusetts Institute of
   Technology (MIT); Broad Institute; Duke University; Stanford University;
   University of Texas System; University of Texas Austin; Northwestern
   University; Feinberg School of Medicine; Inova Health System;
   Northwestern University; Aga Khan University; Cedars Sinai Medical
   Center; Johns Hopkins University
RP Rohatgi, A (corresponding author), UT Southwestern Med Ctr, 5323 Harry Hines Blvd, Dallas, TX 75390 USA.
EM Anand.rohatgi@utsouthwestern.edu
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NR 138
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2666-6677
J9 AM J PREVENT CARDIOL
JI American J. Preventive Cardiology
PD JUN
PY 2025
VL 22
AR 101000
DI 10.1016/j.ajpc.2025.101000
PG 25
WC Cardiac & Cardiovascular Systems
WE Emerging Sources Citation Index (ESCI)
SC Cardiovascular System & Cardiology
GA 2WD2Y
UT WOS:001492736500001
PM 40475260
OA gold
DA 2025-06-11
ER

PT S
AU Tamashiro, KLK
AF Tamashiro, Kellie L. K.
BE McEwen, BS
   Akil, H
   Barchas, JD
   Kreek, MJ
TI Metabolic syndrome: links to social stress and socioeconomic status
SO SOCIAL NEUROSCIENCE: GENE, ENVIRONMENT, BRAIN, BODY
SE Annals of the New York Academy of Sciences
LA English
DT Article; Proceedings Paper
CT 90th Meeting on Social Neuroscience: Gene, Environment, Brain, Body
CY DEC 01, 2010
CL Rockefeller Univ, New York, NY
HO Rockefeller Univ
DE social stress; metabolic syndrome; obesity; glucocorticoids;
   socioeconomic status; epigenetics
ID DIET-INDUCED OBESITY; EARLY-LIFE STRESS; PRENATAL EXPOSURE; BODY-WEIGHT;
   GENE-EXPRESSION; FOOD-INTAKE; GLUCOCORTICOID EXPOSURE; CHRONIC
   CORTICOSTERONE; BRAIN COMPLICATIONS; ADIPOSE-TISSUE
AB Socioeconomic stress associated with financial and psychosocial stress is widespread in society. A comprehensive body of research indicates that low socioeconomic status and social stress is associated with a broad spectrum of health risks. This paper reviews epidemiological evidence demonstrating the association between chronic social stress and development of obesity and symptoms leading to metabolic syndrome. The cumulative effects of socioeconomic stress on health and well being are evident throughout the lifespan, affecting children, adolescents, and adults. While the links between stress and metabolic disease are documented, the mechanisms remain less well understood. Animal models are well established and have provided opportunities to systematically investigate contributing mechanisms that may be targeted to develop treatment and prevention strategies against metabolic disorders arising from exposure to chronic social stress.
C1 Johns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, Baltimore, MD 21205 USA.
C3 Johns Hopkins University
RP Tamashiro, KLK (corresponding author), Johns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, 720 Rutland Ave,Ross 618, Baltimore, MD 21205 USA.
EM ktamashiro@jhmi.edu
OI Tamashiro, Kellie/0000-0002-9398-8796
FU NIH [HD055030, MH-15330, NS047791]; NARSAD; University of Cincinnati;
   Johns Hopkins University
FX Research was supported by NIH Grants HD055030, MH-15330, NS047791, and a
   NARSAD Young Investigator Award. The author is also grateful for the
   continued mentorship and support from Dr. Randall R. Sakai (University
   of Cincinnati) and Dr. Timothy H. Moran (Johns Hopkins University).
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NR 75
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U1 1
U2 48
PU BLACKWELL SCIENCE PUBL
PI OXFORD
PA OSNEY MEAD, OXFORD OX2 0EL, ENGLAND
SN 0077-8923
BN 978-1-57331-840-2
J9 ANN NY ACAD SCI
JI Ann.NY Acad.Sci.
PY 2011
VL 1231
BP 46
EP 55
DI 10.1111/j.1749-6632.2011.06134.x
PG 10
WC Multidisciplinary Sciences
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA BXA61
UT WOS:000295542200006
PM 21884160
DA 2025-06-11
ER

PT J
AU Lohse, B
   Ramirez, A
   Hickey, J
   Bailey-Davis, L
   Drees, B
   Masters, KS
   Ruder, EH
   Trabold, N
AF Lohse, Barbara
   Ramirez, Anahi
   Hickey, Jenna
   Bailey-Davis, Lisa
   Drees, Betty
   Masters, Kevin S.
   Ruder, Elizabeth H.
   Trabold, Nicole
TI Changes in Depressive Symptoms, Perceived Stress, and Food Security
   Among Study Participants With Metabolic Syndrome During a
   COVID-19-Mandated Research Pause
SO PREVENTING CHRONIC DISEASE
LA English
DT Article
ID EATING COMPETENCE; INVENTORY; COVID-19; SF-36
AB Introduction
   We explored how depressive symptoms, perceived stress, and food security of people with metabolic syndrome (MetS) changed during the COVID-19 pandemic.
   Methods
   An online survey was administered from October 2019 through March 2020, to participants in a 2-year lifestyle intervention trial to reverse MetS; the survey was repeated during the COVID-19 pandemic. Outcomes were a change in depressive symptoms, perceived stress, and food security as measured by the Patient Health Questionnaire-8 (PHQ-8), Perceived Stress Scale, and US Department of Agriculture's 10-item Adult Food Security Module. We analyzed changes in outcomes with measures of association, paired t tests, repeated measures, and independent t tests.
   Results
   Survey respondents (N = 132) were mostly female (67%), White (70%), and middle-aged, with a median income of $86,000. Frequency of depressive symptoms increased from baseline to followup and the increase was related to lower mean (SD) baseline vitality (44.4 [20.7] vs 60.3 [18.9]; P =.01) and mental health decline (71.0 [14.3] vs 82.0 [10.4]; P =.002). Mean (SD) perceived stress was significantly higher at baseline than follow-up (18.5 [6.4] vs 14.9 [7.2]; P <.001). Food security increased from 83% at baseline to 90% at follow-up (P <.001). Movement to or continued food insecurity (n = 13) tended to be associated with a racial or ethnic minority group (P =.05).
   Conclusion
   A sample at high risk for COVID-19 did not experience increased stress or food insecurity, but demonstrated increased depressive symptoms after the onset of the COVID-19 pandemic, with some baseline susceptibility.
C1 [Lohse, Barbara; Ruder, Elizabeth H.; Trabold, Nicole] Rochester Inst Technol, Wegmans Sch Hlth & Nutr, 180 Lomb Mem Dr, Rochester, NY 14623 USA.
   [Ramirez, Anahi] Univ Missouri Kansas City, Dept Psychol, Kansas City, MO USA.
   [Bailey-Davis, Lisa] Geisinger Hlth, Dept Populat Hlth Sci, Danville, PA USA.
   [Drees, Betty] Univ Missouri Kansas City, Dept Biomed & Hlth Informat, Kansas City, MO USA.
   [Drees, Betty] Stowers Inst Med Res, Grad Sch, Kansas City, MO USA.
   [Masters, Kevin S.] Univ Colorado Denver, Dept Psychol, Denver, CO USA.
   [Masters, Kevin S.] Univ Colorado Denver, Anschutz Hlth & Wellness Ctr, Denver, CO USA.
C3 Rochester Institute of Technology; University of Missouri System;
   University of Missouri Kansas City; University of Missouri System;
   University of Missouri Kansas City; Stowers Institute for Medical
   Research; University of Colorado System; University of Colorado Anschutz
   Medical Campus; Children's Hospital Colorado; University of Colorado
   Denver; Children's Hospital Colorado; University of Colorado System;
   University of Colorado Anschutz Medical Campus; University of Colorado
   Denver
RP Lohse, B (corresponding author), Rochester Inst Technol, Wegmans Sch Hlth & Nutr, 180 Lomb Mem Dr, Rochester, NY 14623 USA.
EM balihst@rit.edu
OI Bailey-Davis, Lisa/0000-0002-8781-1521
FU William G. McGowan Charitable Fund
FX The authors acknowledge the manuscript preparation assistance of Kathryn
   Faulring, MPH, CHES, Wegmans School of Health and Nutrition, Rochester
   Institute of Technology, and the study site staff. The Satter Eating
   Competence Inventory was used with permission of the Ellyn Satter
   Institute. No other copyrighted materials were used in the study. This
   study was supported by a grant from the William G. McGowan Charitable
   Fund. The sponsor had no role in the design or conduct of the study, the
   decision to publish the results, or the preparation of this manuscript.
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NR 31
TC 3
Z9 3
U1 0
U2 3
PU CENTERS  DISEASE CONTROL & PREVENTION
PI ATLANTA
PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA
SN 1545-1151
J9 PREV CHRONIC DIS
JI Prev. Chronic Dis.
PD DEC
PY 2022
VL 19
AR 220206
DI 10.5888/pcd19.220206
PG 14
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA DA0U8
UT WOS:001129204100001
PM 36580415
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Freire, IV
   dos Santos, DP
   Ribeiro, IJ
   dos Santos, CS
   Coqueiro, RD
   Casotti, CA
   Pereira, R
AF Freire, Ivna Vidal
   dos Santos, Denise Pereira
   Ribeiro, Icaro J. S.
   dos Santos, Caroline Silva
   Coqueiro, Raildo da Silva
   Casotti, Cezar Augusto
   Pereira, Rafael
TI Nutritional Profile and Serum Uric Acid are Associated with Metabolic
   Syndrome in Community-dwelling Older Adults: A Cross-sectional Study
SO EUROPEAN JOURNAL OF GERIATRICS AND GERONTOLOGY
LA English
DT Article
DE Nutrients; micronutrients; oxidative stress; ageing
ID POLYUNSATURATED FATTY-ACIDS; OXIDATIVE STRESS; NATIONAL-HEALTH;
   PREVALENCE; HYPERTENSION; RISK; RECOMMENDATIONS; INFLAMMATION;
   VITAMIN-B-6; POPULATION
AB Objective: This study aimed to evaluate the prevalence of metabolic syndrome in community-dwelling older adults and compare the nutritional profile in macronutrient and micronutrient intakes and serum uric acid in community-dwelling older adults with and without metabolic syndrome.Materials and Methods: Overall, 155 community-dwelling older adults were enrolled and were stratified into two groups: with and without metabolic syndrome. The estimated daily macronutrient and micronutrient intakes and the single umbilical artery (SUA) were obtained and compared between the groups.Results: The prevalence rate of metabolic syndrome was 38.7%, and older adults with metabolic syndrome exhibited greater carbohydrate and lower protein and lipid consumptions. It was observed that the older adults without metabolic syndrome showed higher daily mono- and poly-unsaturated fatty acids, copper and vitamins A and B6 intakes, whereas those with metabolic syndrome exhibited higher daily manganese and vitamin C intakes. Higher SUA was found in older adults with metabolic syndrome, characterising a pro-oxidant state.Conclusion: The nutritional profile adopted by older adults with metabolic syndrome may induce the development of a worrying pro-oxidant state. High carbohydrate consumption could blind the protective effect of a high antioxidant micronutrient intake.
C1 [Freire, Ivna Vidal; dos Santos, Denise Pereira; Ribeiro, Icaro J. S.; Coqueiro, Raildo da Silva; Pereira, Rafael] State Univ Southwest Bahia, Integrat Physiol Res Ctr, Dept Biol Sci, Fac Med, Vitoria Da Conquista, BA, Brazil.
   [Freire, Ivna Vidal; Ribeiro, Icaro J. S.; Casotti, Cezar Augusto; Pereira, Rafael] State Univ Southwest Bahia, Postgrad Program Nursing & Hlth, Jequie, BA, Brazil.
   [dos Santos, Denise Pereira; Pereira, Rafael] State Univ Southwest Bahia, Fac Med, Jequie, BA, Brazil.
   [Coqueiro, Raildo da Silva; Casotti, Cezar Augusto] State Univ Southwest Bahia, Fac Med, Dept Hlth, Jequie, BA, Brazil.
RP Pereira, R (corresponding author), State Univ Southwest Bahia, Integrat Physiol Res Ctr, Dept Biol Sci, Fac Med, Vitoria Da Conquista, BA, Brazil.
EM rpfisiologia@gmail.com
RI Freire, Ivna/F-4913-2018; Pereira, Rafael/L-5195-2013; Ribeiro,
   Icaro/U-8636-2017
OI Pereira, Rafael/0000-0003-1800-1450; Ribeiro, Icaro/0000-0002-4389-7810;
   Coqueiro, Raildo/0000-0003-2278-1234; Silva dos Santos,
   Caroline/0000-0001-9184-2999
FU Fundaco de Amparo a Pesquisa do Estado da Bahia [SUS 0055/2013]
FX This project received financial support from Fundac & atilde;o de Amparo
   a Pesquisa do Estado da Bahia (award numbers SUS 0055/2013) .
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NR 41
TC 0
Z9 0
U1 0
U2 2
PU GALENOS PUBL HOUSE
PI ISTANBUL
PA Kacamak Sokak 21/1, ISTANBUL, Findikzade, TURKIYE
SN 2687-2625
J9 EUR J GERIATR GERONT
JI Eur. J. Geriatr. Gerontol.
PD APR
PY 2021
VL 3
IS 1
BP 4
EP 11
DI 10.4274/ejgg.galenos.2020.378
PG 8
WC Geriatrics & Gerontology
WE Emerging Sources Citation Index (ESCI)
SC Geriatrics & Gerontology
GA Y6DZ5
UT WOS:001106157500003
OA gold
DA 2025-06-11
ER

PT J
AU Jahrami, H
   BaHammam, AS
   Haji, EA
   Bragazzi, NL
   Rakha, I
   Alsabbagh, A
   Nugraha, B
   Pasiakos, SM
AF Jahrami, Haitham
   BaHammam, Ahmed S.
   Haji, Eman Ahmed
   Bragazzi, Nicola L.
   Rakha, Ihab
   Alsabbagh, Amani
   Nugraha, Boya
   Pasiakos, Stefan M.
TI Ramadan Fasting Improves Body Composition without Exacerbating
   Depression in Males with Diagnosed Major Depressive Disorders
SO NUTRIENTS
LA English
DT Article
DE depression; intermittent fasting; mood disorders; metabolic syndrome
ID METABOLIC SYNDROME; WEIGHT-LOSS; RISK; METAANALYSIS; RESTRICTION;
   RESPONSES; ANXIETY; OBESITY; PEOPLE; TRIAL
AB Background: Ramadan fasting (RF) is a form of intermittent fasting that generally improves body composition and related metabolic profiles. Whether RF exacerbates depressive symptomatology in individuals diagnosed with major depressive disorder (MDD) is undetermined. Methods: 100 men, who lived in Bahrain and were between the ages of 18 and 64 years with an established diagnosis of MDD, participated in this 4-week study. Based on preference, participants were assigned to a fasting group (FG, n = 50) and a non-fasting group (NFG, n = 50). The FG engaged in fasting from 03:40 to 18:10 (dawn and dusk timings). Changes in depressive symptoms, body mass, body composition, and components of metabolic syndrome were measured. Results: There were no significant changes in depressive symptoms within the FG vs. NFG after controlling for baseline covariates: mean difference 0.49 (SE = 0.63), p = 0.43. No adverse effects were reported in either group. The FG experienced significant reductions in body mass, 1.87 kg, p = 0.001; body mass index, 0.69 kg/m(2), p = 0.001; body fat, 0.87%, p = 0.001; body surface area, 0.03 m(2), p = 0.001; and lean mass, 0.77 kg, p = 0.001. Conclusions: RF did not negatively affect depressive symptoms and improved body composition, suggesting short-term intermittent fasting may be a safe dietary practice for adult males with MDD.
C1 [Jahrami, Haitham; Haji, Eman Ahmed; Rakha, Ihab; Alsabbagh, Amani] Minist Hlth, Manama 410, Bahrain.
   [Jahrami, Haitham; Haji, Eman Ahmed] Arabian Gulf Univ, Dept Psychiat, Coll Med & Med Sci, Manama 323, Bahrain.
   [BaHammam, Ahmed S.] King Saud Univ, Univ Sleep Disorders Ctr, Dept Med, Coll Med, POB 225503, Riyadh 11324, Saudi Arabia.
   [BaHammam, Ahmed S.] Natl Plan Sci & Technol & Innovat Kingdom Saudi A, Strateg Technol Program, Riyadh 11324, Saudi Arabia.
   [Bragazzi, Nicola L.] York Univ, Dept & Stat, Lab Ind & Appl Math, Toronto, ON M3J 1P3, Canada.
   [Nugraha, Boya] Hannover Med Sch, Dept Rehabil Med, D-30625 Hannover, Germany.
   [Pasiakos, Stefan M.] US Army, Mil Nutr Div, Res Inst Environm Med, Natick, MA 01760 USA.
C3 Ministry of Health - Bahrain; Arabian Gulf University; King Saud
   University; York University - Canada; Hannover Medical School
RP Jahrami, H (corresponding author), Minist Hlth, Manama 410, Bahrain.; Jahrami, H (corresponding author), Arabian Gulf Univ, Dept Psychiat, Coll Med & Med Sci, Manama 323, Bahrain.; Bragazzi, NL (corresponding author), York Univ, Dept & Stat, Lab Ind & Appl Math, Toronto, ON M3J 1P3, Canada.
EM Hjahrami@health.gov.bh; ashammam2@gmail.com; EHaji@health.gov.bh;
   robertobragazzi@gmail.com; IRakha@health.gov.bh;
   ASabbagh4@health.gov.bh; boya.nugraha@gmail.com;
   stefan.m.pasiakos.civ@mail.mil
RI Nugraha, Boya/AAJ-6001-2020; Jahrami, Haitham/JVO-6632-2024; Pasiakos,
   Stefan/E-6295-2014; BaHammam, Ahmed/B-9037-2008; Bragazzi,
   Nicola/G-1672-2011
OI BaHammam, Ahmed/0000-0002-1706-6167; Nugraha, Boya/0000-0002-5547-3169;
   Bragazzi, Nicola/0000-0001-8409-868X; Jahrami,
   Haitham/0000-0001-8990-1320
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   Zhang YF, 2015, CURR NEUROPHARMACOL, V13, P536, DOI 10.2174/1570159X13666150326003852
NR 46
TC 13
Z9 13
U1 0
U2 10
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD AUG
PY 2021
VL 13
IS 8
AR 2718
DI 10.3390/nu13082718
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nutrition & Dietetics
GA UH6HQ
UT WOS:000690029800001
PM 34444878
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Gupta, MA
   Simpson, FC
AF Gupta, Madhulika A.
   Simpson, Fiona C.
TI Obstructive Sleep Apnea and Psychiatric Disorders: A Systematic Review
SO JOURNAL OF CLINICAL SLEEP MEDICINE
LA English
DT Review
DE obstructive sleep apnea; psychiatry; PTSD; depression; comorbidity
ID POSTTRAUMATIC-STRESS-DISORDER; POSITIVE AIRWAY PRESSURE; SEVERE
   MENTAL-ILLNESS; QUALITY-OF-LIFE; EXCESSIVE SLEEPINESS; DEPRESSIVE
   SYMPTOMS; METABOLIC SYNDROME; NEGATIVE SYMPTOMS; MAJOR DEPRESSION; CPAP
   TREATMENT
AB Study Objectives: Obstructive sleep apnea (OSA) has been associated with psychiatric pathology. Psychiatric comorbidity in OSA may affect patient quality of life and adherence to CPAP. A focused evaluation of OSA in highly selected groups of primarily psychiatric patients may provide further insights into the factors contributing to comorbidity of OSA and psychopathology. The goal of this study is to examine the prevalence and treatment of OSA in psychiatric populations.
   Methods: A systematic review following the PRISMA guidelines was conducted to determine the prevalence of OSA in schizophrenia and other psychotic disorders, mood disorders, and anxiety disorders, and to examine potential interventions. The PubMed, EMBASE, and PsycINFO databases were searched (last search April 26, 2014) using keywords based on the ICD-9-CM coding for OSA and the DSM-IV-TR diagnostic groups.
   Results: The search retrieved 48 records concerning studies of OSA in the selected disorders. The prevalence studies indicate that there may be an increased prevalence of OSA in individuals with major depressive disorder (MDD) and posttraumatic stress disorder (PTSD), despite considerable heterogeneity and a high risk of bias. There was insufficient evidence to support increased OSA in schizophrenia and psychotic disorders, bipolar and related disorders, and anxiety disorders other than PTSD. Studies of treatment of OSA indicate an improvement in both OSA and psychiatric symptoms. CPAP adherence was reduced in veterans with PTSD.
   Conclusions: OSA prevalence may be increased in MDD and PTSD. In individuals with OSA and psychiatric illness, treatment of both disorders should be considered for optimal treatment outcomes.
C1 [Gupta, Madhulika A.; Simpson, Fiona C.] Univ Western Ontario, Dept Psychiat, Schulich Sch Med & Dent, London, ON N6A 3K7, Canada.
C3 Western University (University of Western Ontario)
RP Gupta, MA (corresponding author), 585 Springbank Dr,Suite 101, London, ON N6J 1H3, Canada.
EM magupta@uwo.ca
RI Simpson, Fiona/A-1348-2014
OI Simpson, Fiona/0000-0003-3534-050X
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NR 97
TC 227
Z9 244
U1 1
U2 52
PU AMER ACAD SLEEP MEDICINE
PI DARIEN
PA 2510 N FRONTAGE RD, DARIEN, IL 60561 USA
SN 1550-9389
EI 1550-9397
J9 J CLIN SLEEP MED
JI J. Clin. Sleep Med.
PY 2015
VL 11
IS 2
BP 165
EP U110
DI 10.5664/jcsm.4466
PG 35
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology
GA CE9CI
UT WOS:000352140800012
PM 25406268
OA Green Published
DA 2025-06-11
ER

PT J
AU Ayala, F
   Ayala, F
AF Ayala, Fabio
   Ayala, Fabrizio
TI Clinical Aspects and Comorbidities of Psoriasis
SO JOURNAL OF RHEUMATOLOGY
LA English
DT Article; Proceedings Paper
CT Conference on Procida Update of Psoriatic Disease
CY MAY 22-24, 2008
CL Procida, ITALY
DE PSORIASIS; CARDIOVASCULAR DISEASE; DIABETES; HYPERTENSION; METABOLIC
   SYNDROME; OBESITY
ID OBESITY; ARTHRITIS; IMPACT
AB Psoriasis is a disease mediated by Th1 and Th17 cytokines that has different phenotypes (plaque, guttate, pustular, and erythrodermic type). Aside from the well known psoriatic arthritis, associated disorders may occur more frequently than expected, including Crohn's disease, anxiety/depression, and metabolic syndrome. This is based on a constellation of different factors, including abdominal obesity, atherogenic dyslipidemia, hypertension, and glucose intolerance, and is a strong predictor of type 2 diabetes, cardiovascular disease, and stroke. People with moderate to severe psoriasis have more risk for cardiac disease, presumably due to the inflammatory nature of psoriasis, causing inflammatory changes in coronary arteries. The strong association between psoriasis and obesity potentially makes psoriasis an important healthcare issue. Since cardiovascular risk factors are higher in psoriatic patients, dermatologists treating moderate to severe psoriasis should screen for their presence, thus approaching psoriasis as a potential multisystem disorder. (J Rheumatol 2009;36 Suppl 83:19-20; doi: 10.3899/jrheum.090214)
C1 [Ayala, Fabio] Univ Naples Federico II, Div Dermatol, Dept Systemat Pathol, I-80131 Naples, Italy.
   Natl Canc Inst G Pascale, Naples, Italy.
C3 University of Naples Federico II; IRCCS Fondazione Pascale
RP Ayala, F (corresponding author), Univ Naples Federico II, Div Dermatol, Dept Systemat Pathol, Via Pansini 5, I-80131 Naples, Italy.
OI Ayala, Fabio/0000-0002-2596-1268
CR Ayala F, 2007, REUMATISMO, V59, P40, DOI 10.4081/reumatismo.2007.1s.40
   Christophers E, 2007, CLIN DERMATOL, V25, P529, DOI 10.1016/j.clindermatol.2007.08.006
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   Sterry W, 2007, BRIT J DERMATOL, V157, P649, DOI 10.1111/j.1365-2133.2007.08068.x
NR 15
TC 12
Z9 12
U1 0
U2 3
PU J RHEUMATOL PUBL CO
PI TORONTO
PA 365 BLOOR ST E, STE 901, TORONTO, ONTARIO M4W 3L4, CANADA
SN 0315-162X
EI 1499-2752
J9 J RHEUMATOL
JI J. Rheumatol.
PD AUG
PY 2009
VL 36
SU 83
BP 19
EP 20
DI 10.3899/jrheum.090214
PG 2
WC Rheumatology
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Rheumatology
GA 485ZJ
UT WOS:000269164800007
PM 19661531
OA Bronze
DA 2025-06-11
ER

PT J
AU Diao, ZH
   Guo, DY
   Zhang, JZ
   Zhang, RY
   Li, CJ
   Chen, H
   Ma, YX
AF Diao, Zhihao
   Guo, Danyang
   Zhang, Jingzhi
   Zhang, Ruiyu
   Li, Chunjing
   Chen, Hao
   Ma, Yuxia
TI Causal relationship between modifiable risk factors and knee
   osteoarthritis: a Mendelian randomization study
SO FRONTIERS IN MEDICINE
LA English
DT Article
DE Mendelian randomization; knee osteoarthritis; risk factors; causal
   relationship; genetic variants
ID MICRORNA EXPRESSION; SPA THERAPY; BALNEOTHERAPY; ASSOCIATION; COHORT;
   PAIN; EPIDEMIOLOGY; HYPERTENSION; HEIGHT; PEOPLE
AB Background While several risk factors for knee osteoarthritis (KOA) have been recognized, the pathogenesis of KOA and the causal relationship between modifiable risk factors and KOA in genetic epidemiology remain unclear. This study aimed to determine the causal relationship between KOA and its risk factors.Methods Data were obtained from published Genome-Wide Association study (GWAS) databases. A two-sample Mendelian randomization (MR) analysis was performed with genetic variants associated with risk factors as instrumental variables and KOA as outcome. First, inverse variance weighting was used as the main MR analysis method, and then a series of sensitivity analyses were conducted to comprehensively evaluate the causal relationship between them.Results Univariate forward MR analysis revealed that genetically predicted hypothyroidism, hyperthyroidism/thyrotoxicosis, educational level, income level, metabolic syndrome (MS), essential hypertension, height, hot drink temperature, diet (abstaining from sugar-sweetened or wheat products), and psychological and psychiatric disorders (stress, depression, and anxiety) were causally associated with KOA. Reverse MR exhibits a causal association between KOA and educational attainment. Multivariate MR analysis adjusted for the inclusion of potential mediators, such as body mass index (BMI), smoking, alcohol consumption, and sex, exhibited some variation in causal effects. However, hyperthyroidism/thyrotoxicosis had a significant causal effect on KOA, and there was good evidence that height, hypothyroidism, educational level, psychological and psychiatric disorders (stress, depression, and anxiety), and abstaining from wheat products had an independent causal relationship. The mediating effect of BMI as a mediator was also identified.Conclusion This study used MR to validate the causal relationship between KOA and its risk factors, providing new insights for preventing and treating KOA in clinical practice and for developing public health policies.
C1 [Diao, Zhihao; Zhang, Jingzhi; Zhang, Ruiyu; Li, Chunjing; Ma, Yuxia] Shandong Univ Tradit Chinese Med, Sch Acupuncture & Tuina, Jinan, Peoples R China.
   [Guo, Danyang] Shandong Univ Tradit Chinese Med, Clin Med Coll 1, Jinan, Peoples R China.
   [Chen, Hao] Univ Complutense Madrid, Madrid, Spain.
C3 Shandong University of Traditional Chinese Medicine; Shandong University
   of Traditional Chinese Medicine; Complutense University of Madrid
RP Ma, YX (corresponding author), Shandong Univ Tradit Chinese Med, Sch Acupuncture & Tuina, Jinan, Peoples R China.
EM dzh971211@163.com
FU fifth batch of special funds for the Training Program for Outstanding
   Clinical Talents of Traditional Chinese Medicine [National Letter of TCM
   Education] [2022]; Natural Science Foundation of Shandong Province
   [ZR2021MH373]; High Level Traditional Chinese Medicine Key Disciplines
   of the State Administration of Traditional Chinese Medicine-External
   Treatment of Traditional Chinese Medicine [zyyzdxk-2023116]; Shandong
   Traditional Chinese Medicine Science and Technology Project [2020Q002];
   Jinan University [2020GXRC005]
FX The author(s) declare that financial support was received for the
   research, authorship, and/or publication of this article. This work was
   supported by the fifth batch of special funds for the Training Program
   for Outstanding Clinical Talents of Traditional Chinese Medicine
   [National Letter of TCM Education (2022) No. 1]; the Natural Science
   Foundation of Shandong Province (ZR2021MH373); High Level Traditional
   Chinese Medicine Key Disciplines of the State Administration of
   Traditional Chinese Medicine-External Treatment of Traditional Chinese
   Medicine(zyyzdxk-2023116); Shandong Traditional Chinese Medicine Science
   and Technology Project (2020Q002); and the Jinan University 20 Funding
   Project (2020GXRC005).
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NR 114
TC 1
Z9 1
U1 4
U2 7
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 2296-858X
J9 FRONT MED-LAUSANNE
JI Front. Med.
PD SEP 2
PY 2024
VL 11
AR 1405188
DI 10.3389/fmed.2024.1405188
PG 13
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA H0K2N
UT WOS:001320415200001
PM 39286647
OA gold
DA 2025-06-11
ER

PT J
AU John, AP
   Koloth, R
   Dragovic, M
   Lim, SCB
AF John, Alexander P.
   Koloth, Radhakrishnan
   Dragovic, Milan
   Lim, Stephen C. B.
TI Prevalence of metabolic syndrome among Australians with severe mental
   illness
SO MEDICAL JOURNAL OF AUSTRALIA
LA English
DT Article
ID PSYCHOTIC DISORDERS; BIPOLAR-DISORDER; SCHIZOPHRENIA; RISK; OBESITY;
   DISEASE
AB Objective: To assess the prevalence of metabolic syndrome and its association with sociodemographic, clinical and lifestyle variables among Australian patients with a variety of psychiatric disorders.
   Design and setting: Cross-sectional study of patients attending a public mental health service in Western Australia between July 2005 and September 2006. Participants: Patients who were aged 18-65 years; diagnosed with schizophrenia, schizoaffective disorder, bipolar disorder, major depressive disorder with psychotic symptoms, drug-induced psychosis or borderline personality disorder; and currently taking at least one antipsychotic drug for a minimum of 2 weeks.
   Main outcome measures: Prevalence of metabolic syndrome diagnosed with International Diabetes Federation criteria; fasting blood glucose and lipid levels; sociodemographic and lifestyle characteristics.
   Results: Of 219 patients invited to participate, 203 agreed and had complete data. Prevalence of metabolic syndrome was 54% overall, and highest among patients with bipolar disorder or schizoaffective disorder (both 67%), followed by schizophrenia (51%). Sociodemographic variables, including age and ethnic background, were not significantly associated with metabolic syndrome, but a strong association was seen with mean body mass index. Other cardiovascular risk factors, such as smoking and substance misuse, were common among participants.
   Conclusions: Prevalence of metabolic syndrome in this population was almost double that in the general Australian population, and patients with schizophrenia had a prevalence among the highest in the developed world. Prevalence was also high in patients with a variety of other psychiatric disorders.
C1 [John, Alexander P.] Bentley Hlth Serv, Perth, WA, Australia.
   [Koloth, Radhakrishnan; Lim, Stephen C. B.] Armadale Mental Hlth Serv, Armadale, WA, Australia.
   [Dragovic, Milan] Univ Western Australia, Ctr Clin Res Neuropsychiat, Sch Psychiat & Clin Neurosci, Perth, WA 6009, Australia.
C3 East Metropolitan Health Service; Bentley Health Service; University of
   Western Australia
RP John, AP (corresponding author), Bentley Hlth Serv, Perth, WA, Australia.
EM Alexander.John@health.wa.gov.au
RI Koloth, Radhakrishnan/GAH-8640-2022
OI Koloth, Radhakrishnan/0009-0006-9763-0528; JOHN,
   ALEXANDER/0000-0002-1989-6578
FU Armadale Mental Health Service
FX We acknowledge the valuable contributions of Dr Maha Boulos, Dr Rajan
   Iyallol, Mr Roger Au and Dr Brenda Cuk (all of Armadale Mental Health
   Service) to this study.
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NR 25
TC 98
Z9 107
U1 0
U2 11
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0025-729X
EI 1326-5377
J9 MED J AUSTRALIA
JI Med. J. Aust.
PD FEB 16
PY 2009
VL 190
IS 4
BP 176
EP 179
DI 10.5694/j.1326-5377.2009.tb02342.x
PG 4
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA 429TF
UT WOS:000264942300005
PM 19220180
DA 2025-06-11
ER

PT J
AU Toledo-Corral, CM
   Ding, L
   Morales, JC
   Chapman, TM
   Romero, MB
   Weigensberg, MJ
AF Toledo-Corral, Claudia M. M.
   Ding, Li
   Morales, Jeremy C. C.
   Chapman, Tiffany M. M.
   Romero, Melyssa B. B.
   Weigensberg, Marc J. J.
TI Morning Serum Cortisol Is Uniquely Associated with Cardiometabolic Risk
   Independent of Body Composition in Latino Adolescents
SO METABOLIC SYNDROME AND RELATED DISORDERS
LA English
DT Article
DE serum cortisol; obesity; cardiovascular risk; Hispanic; pediatric;
   stress
ID PITUITARY-ADRENAL AXIS; BETA-CELL FUNCTION; FREE FATTY-ACIDS;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; SALIVARY CORTISOL;
   BLOOD-PRESSURE; HAIR CORTISOL; OVERWEIGHT; CHILDREN
AB Background: Alterations in morning serum cortisol (MSC) have been associated with higher cardiometabolic risk. This finding has been documented primarily in populations with overweight or obesity; however, it has not been clearly established if obesity plays a requisite role in this relationship. This study seeks to extend earlier findings by examining whether body composition measures alter the relationship between MSC with glucose and insulin markers, blood pressure, and lipid parameters in Latino youth in middle adolescence.Methods: This cross-sectional study included 196 healthy adolescents (130F/66M; mean age: 16.4 +/- 0.6 years; 95% Latino; mean body mass index, BMI: 24.3 +/- 5.7) from Los Angeles, California. Morning cortisol, glucose, insulin, glycated hemoglobin, and lipids (triglycerides and high-density lipoprotein cholesterol) were assessed from a fasting blood sample. Sitting systolic and diastolic blood pressure was averaged from duplicate measures. Body composition measures included BMI and waist circumference, which were used as proxies for total body and abdominal adiposity, respectively. Triplicate measurements of weight and height were averaged for calculation of BMI; age- and sex-specific BMI z-score was used to classify into normal BMI or overweight/obese BMI status. Waist circumference was measured in duplicate and the average was used to classify participants into two strata: normal/healthy waist circumference (<90th percentile for age, sex, and ethnicity) and high waist circumference (>= 90th percentile).Results: The primary findings were that higher MSC was associated with higher fasting glucose and systolic blood pressure after adjusting for age, sex, and BMI z-score (and/or waist circumference). BMI status or waist circumference status did not alter these relationships.Main Conclusion: Our results suggest that the relationships between hypothalamic-pituitary-adrenal axis function and certain cardiometabolic risk factors may be independent of adiposity. Future research is warranted to discover the contributors and underlying mechanisms of these relationships in adolescent populations.ClinicalTrials.gov identifier: NCT02088294.
C1 [Toledo-Corral, Claudia M. M.] Calif State Univ Northridge, Dept Hlth Sci, 18111 Nordhoff St, Northridge, CA 91330 USA.
   [Toledo-Corral, Claudia M. M.] Calif State Univ Northridge, Hlth Equ & Res Educ HERE Ctr, 18111 Nordhoff St, Northridge, CA 91330 USA.
   [Ding, Li; Morales, Jeremy C. C.; Chapman, Tiffany M. M.; Romero, Melyssa B. B.] Univ Southern Calif, Dept Populat & Publ Hlth Sci, Los Angeles, CA USA.
   [Weigensberg, Marc J. J.] Univ Southern Calif, Dept Pediat, Los Angeles, CA USA.
C3 California State University System; California State University
   Northridge; California State University System; California State
   University Northridge; University of Southern California; University of
   Southern California
RP Toledo-Corral, CM (corresponding author), Calif State Univ Northridge, Dept Hlth Sci, 18111 Nordhoff St, Northridge, CA 91330 USA.
EM claudia.toledo-corral@csun.edu
RI DING, LI/ABI-1989-2020; Toledo-Corral, Claudia/J-5299-2019
OI Toledo-Corral, Claudia/0000-0002-1228-9070; Chapman,
   Tiffany/0000-0003-3947-103X
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NR 41
TC 2
Z9 2
U1 0
U2 2
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-4196
EI 1557-8518
J9 METAB SYNDR RELAT D
JI Metab. Syndr. Relat. Disord.
PD MAY 1
PY 2023
VL 21
IS 4
BP 214
EP 221
DI 10.1089/met.2022.0091
EA APR 2023
PG 8
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA A3Z8K
UT WOS:000967463400001
PM 37042653
OA Green Published
DA 2025-06-11
ER

PT J
AU Motamedi, S
   Karimi, I
   Jafari, F
AF Motamedi, Shima
   Karimi, Isaac
   Jafari, Fariba
TI The interrelationship of metabolic syndrome and neurodegenerative
   diseases with focus on brain-derived neurotrophic factor (BDNF): Kill
   two birds with one stone
SO METABOLIC BRAIN DISEASE
LA English
DT Review
DE BDNF; Metabolic syndrome; Neurodegenerative diseases; Obesity;
   Depression
ID BIPOLAR DISORDER; ADIPOSE-TISSUE; ASSOCIATION; OBESITY; EXPRESSION;
   MICE; SEROTONIN; SIRT1; SUSCEPTIBILITY; POLYMORPHISM
AB The brain-derived neurotrophic factor (BDNF) is involved in metabolic syndrome (MetS) and neurodegenerative diseases (NDD) like Alzheimer's disease, Huntington's disease, Parkinson's disease and depression. If one factor plays an essential role in the pathogenesis of two diseases, it can be concluded that there might be a common root in these two diseases, as well. This review was aimed to highlight the crucial roles of BDNF in the pathogenesis of MetS and NDD and to introduce sole prophylactic or therapeutic applications, BDNF gene therapy and BDFN administration, in controlling MetS and NDD.
C1 [Karimi, Isaac] Razi Univ, Dept Biol, Fac Sci, Kermanshah, Iran.
   [Jafari, Fariba] Islamic Azad Univ, Isfahan Khorasgan Branch, Young Researchers & Elite Club, Esfahan, Iran.
C3 Razi University; Islamic Azad University
RP Karimi, I (corresponding author), Razi Univ, Dept Biol, Fac Sci, Kermanshah, Iran.
EM karimiisaac@razi.ac.ir
RI karimi, isaac/E-7755-2013
OI karimi, isaac/0000-0001-7415-0472
FU grant for proposal entitled "Neurobehavioral changes of mouse model of
   metabolic syndrome based on measurement of amount and gene expression of
   brain-derived neurotrophic factor" [90007951]
FX This study was supported by grant for proposal entitled "Neurobehavioral
   changes of mouse model of metabolic syndrome based on measurement of
   amount and gene expression of brain-derived neurotrophic factor" (number
   90007951) accepted by the Iran National Science Foundation (INSF).
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NR 73
TC 73
Z9 74
U1 0
U2 25
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0885-7490
EI 1573-7365
J9 METAB BRAIN DIS
JI Metab. Brain Dis.
PD JUN
PY 2017
VL 32
IS 3
BP 651
EP 665
DI 10.1007/s11011-017-9997-0
PG 15
WC Endocrinology & Metabolism; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology
GA EU1HP
UT WOS:000400767700001
PM 28361262
DA 2025-06-11
ER

PT J
AU Barinas-Mitchell, E
   Yang, X
   Matthews, KA
   Columbus, ML
   George, CJ
   Dósa, E
   Kiss, E
   Kapornai, K
   Evans, R
   Kovacs, M
AF Barinas-Mitchell, Emma
   Yang, Xiao
   Matthews, Karen A.
   Columbus, Mindy L.
   George, Charles J.
   Dosa, Edit
   Kiss, Eniko
   Kapornai, Krisztina
   Evans, Rhobert
   Kovacs, Maria
TI Childhood-onset depression and arterial stiffness in young adulthood
SO JOURNAL OF PSYCHOSOMATIC RESEARCH
LA English
DT Article
DE Childhood depression; Arterial stiffness; Major depressive episode;
   Dysthymic disorder; Cardiovascular risk
ID PULSE-WAVE VELOCITY; CARDIOVASCULAR-DISEASE; PATHOBIOLOGICAL
   DETERMINANTS; RISK-FACTORS; ATHEROSCLEROSIS; YOUTH; DISORDER; PEOPLE;
   ASSOCIATION; ADOLESCENTS
AB Objectives: The literature on childhood-onset depression and future compromised vascular function is suggestive but limited. The objective of this study was to determine if arterial stiffness, a predictor of future cardiovascular disease (CVD), measured in young adulthood, is associated with childhood-onset depression. Methods: Cardiometabolic risk factors and pulse wave velocity (PWV), a measure of arterial stiffness, were crosssectionally assessed in young adults with a history of childhood-onset depression (clinical diagnosis of major depressive episode or dysthymic disorder; N = 294 probands; initially recruited via child mental health facilities across Hungary; mean age of first depressive episode = 10.4 years), their never-depressed full biological siblings (N = 269), and never-depressed controls (N = 169). The mean ages of probands, siblings, and controls at the PWV visit were 25.6, 25.0, and 21.7 years, respectively, and 8.8% of the probands were in a current depressive episode. Results: Controlling for age, sex, age*sex, education, and family clusters, PWV (m/s) did not statistically differ across the groups (probands = 7.01; siblings = 6.98; controls = 6.81). However, after adjusting for key covariates, there were several across-group differences in CVD risk factors: compared to controls, probands and siblings had higher diastolic blood pressure and lower high-density lipoprotein cholesterol, probands had higher triglycerides, and siblings had higher body mass index (all p < 0.05). Conclusion: We found limited evidence of an association between a history of childhood-onset depression and young adulthood arterial stiffness. However, our findings of elevated cardiovascular risk factors in those with childhood-onset depression suggest that pediatric depression may predispose to increased CVD risk later in life and warrants further investigation.
C1 [Barinas-Mitchell, Emma; Columbus, Mindy L.; Evans, Rhobert] Univ Pittsburgh, Dept Epidemiol, Pittsburgh, PA 15261 USA.
   [Yang, Xiao; Matthews, Karen A.; George, Charles J.; Kovacs, Maria] Univ Pittsburgh, Dept Psychiat, Pittsburgh, PA USA.
   [Dosa, Edit] Semmelweis Univ, Heart & Vasc Ctr, Dept Intervent Radiol, Budapest, Hungary.
   [Dosa, Edit] Hungarian Vasc Radiol Res Grp, Budapest, Hungary.
   [Kiss, Eniko; Kapornai, Krisztina] Univ Szeged, Child & Adolescent Psychiat Unit, Dept Pediat, Szeged, Hungary.
   [Kiss, Eniko; Kapornai, Krisztina] Univ Szeged, Child & Adolescent Psychiat Unit, Child Hlth Ctr, Szeged, Hungary.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE); University
   of Pittsburgh; Pennsylvania Commonwealth System of Higher Education
   (PCSHE); University of Pittsburgh; Semmelweis University; Szeged
   University; Szeged University
RP Barinas-Mitchell, E (corresponding author), Univ Pittsburgh, Grad Sch Publ Hlth, Dept Epidemiol, 130 N Bellefield Ave,Suite 338, Pittsburgh, PA 15213 USA.
EM ejb4@pitt.edu
RI Yan, Xiaoliang/O-8215-2016
OI Barinas-Mitchell, Emma/0000-0002-7280-7781; xiao,
   yang/0000-0003-1246-7065
FU National Heart, Lung, and Blood Institute [R01 HL122648]
FX Research reported in this publication was supported by the National
   Heart, Lung, and Blood Institute under award number R01 HL122648 (Kovacs
   and Matthews). Its content is solely the responsibility of the authors
   and does not necessarily represent the official views of the National
   Institutes of Health.
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NR 34
TC 12
Z9 12
U1 0
U2 4
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-3999
EI 1879-1360
J9 J PSYCHOSOM RES
JI J. Psychosomat. Res.
PD SEP
PY 2021
VL 148
AR 110551
DI 10.1016/j.jpsychores.2021.110551
EA JUN 2021
PG 6
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA TT3MA
UT WOS:000680254000019
PM 34174712
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Williams, RB
AF Williams, Redford B.
TI Psychosocial and biobehavioral factors and their interplay in coronary
   heart disease
SO ANNUAL REVIEW OF CLINICAL PSYCHOLOGY
SE Annual Review of Clinical Psychology
LA English
DT Article; Book Chapter
DE stress; genetics; behavioral interventions; hostility; depression;
   mechanisms
ID TRANSPORTER GENE POLYMORPHISM; BLOOD-PRESSURE REACTIVITY;
   MYOCARDIAL-INFARCTION; CARDIOVASCULAR-RESPONSES; PSYCHOLOGICAL STRESS;
   METABOLIC SYNDROME; RISK-FACTORS; SEROTONERGIC RESPONSIVITY;
   SOCIOECONOMIC-STATUS; DEPRESSIVE SYMPTOMS
AB Recent epidemiological research has confirmed that psychosocial factors are associated with increased risk of developing coronary heart disease (CHD), a major cause of death and disability worldwide. This association is probably mediated by changes in health risk behaviors and neuroendocrine and autonomic functions that affect metabolic, hemostatic, inflammatory, and cardiovascular functions that are the proximal agents in CHD pathogenesis over time as well as the precipitation of acute disease events. Recent developments in genomics have now made it possible to begin the process of identifying specific genetic variants that act either independently or via moderation of the impact of exposures to stressful environmental situations to increase the expression of these health-damaging psychosocial factors and the accompanying behavioral and physiological changes that lead to disease. It will be possible ultimately to use the knowledge emerging from research on gene x environment interactions that affect expression of psychosocial risk factors, health risk behaviors, and biological changes inside the body to speed the development of a new field of prospective medicine-a field where instead of spending the majority of health care resources on the treatment of chronic diseases at the end of life, it will be possible to allocate more resources to develop, test, and implement earlier in the disease process cost-effective, proactive interventions that target persons at high risk.
C1 Duke Univ, Med Ctr, Behav Med Res, Durham, NC 27710 USA.
C3 Duke University
RP Williams, RB (corresponding author), Duke Univ, Med Ctr, Behav Med Res, Durham, NC 27710 USA.
EM redfordw@duke.edu
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NR 81
TC 46
Z9 51
U1 0
U2 14
PU ANNUAL REVIEWS
PI PALO ALTO
PA 4139 EL CAMINO WAY, PO BOX 10139, PALO ALTO, CA 94303-0139 USA
SN 1548-5943
EI 1548-5951
J9 ANNU REV CLIN PSYCHO
JI Annu. Rev. Clin. Psychol.
PY 2008
VL 4
BP 349
EP 365
DI 10.1146/annurev.clinpsy.4.022007.141237
PG 17
WC Psychology, Clinical; Psychology
WE Book Citation Index – Social Sciences & Humanities (BKCI-SSH); Book Citation Index – Science (BKCI-S); Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology
GA 297WW
UT WOS:000255649100015
PM 17716037
DA 2025-06-11
ER

PT J
AU Mantadaki, AE
   Linardakis, M
   Vafeiadi, M
   Anastasiou, F
   Tsatsakis, A
   Symvoulakis, EK
AF Mantadaki, Aikaterini E.
   Linardakis, Manolis
   Vafeiadi, Marina
   Anastasiou, Foteini
   Tsatsakis, Aristidis
   Symvoulakis, Emmanouil K.
TI The Impact of Three-Month Quercetin Intake on Quality of Life and
   Anxiety in Patients With Type II Diabetes Mellitus: An Early Data
   Analysis From a Randomized Controlled Trial
SO CUREUS JOURNAL OF MEDICAL SCIENCE
LA English
DT Article
DE nutraceutical; phytochemical; type ii diabetes; anxiety; quality of
   life; diabetes mellitus; quercetin
ID CARDIOVASCULAR RISK-FACTORS; METABOLIC SYNDROME; DOUBLE-BLIND;
   CARDIOMETABOLIC RISK; OXIDATIVE STRESS; SCREENING-TEST; HEALTH;
   SUPPLEMENTATION; FLAVONOIDS; SF-36
AB Background: Diabetes is a high -prevalence, major chronic metabolic disease demanding effective interventions. Quercetin, a phytochemical with potential health benefits, has garnered interest for its therapeutic properties. Aim: This study was designed to capture the early efficacy and clinical safety aspects following quercetin administration in patients with type II diabetes mellitus (T2DM). Methods: The main study involved a randomized allocation procedure to assign non -insulin -treated patients attending the 4th Health Unit of Heraklion to intervention and control groups based on age and sex. The intervention group (n=50) received 500 mg of quercetin daily for 12 + (8 free intervals) + 12 weeks, alongside their usual treatment, while the control group (n=50) did not. After randomization, for the intermediary 12week follow-up, data from 38 patients (intervention: 20; control: 18) were analyzed in this report. All subjects provided informed consent for the collection of anthropometric measurements, vital signs, daily habits data, and PiKo-6 spirometric readings. Additionally, participants responded to the Short Anxiety Screening Test (SAST) and the 36 -Item Short Form Health Survey (SF -36) questionnaires. Results: Thirty-eight participants were included (60% men and 40% women in the intervention group; 38.9% men and 61.1% women in the control group). In the treatment arm, Forced Expiratory Volume in the first second (FEV1) measured with PiKo-6 showed a Delta%- change for the intervention arm: +6.8%, control: -0.2% (p=0.059), systolic blood pressure; intervention: -7.4%, control: -3.7% (p=0.117), waist circumference; intervention: -1.5% control: -0.7% (p=0.455) and night-time sleep; intervention: +5.3%, control: +1.4% (p=0.926) were favourably influenced. The treatment group exhibited significant enhancements in both anxiety levels assessed by the anxiety symptoms scale (SAST-10, p=0.026) and quality of life evaluated by the SF -36 (p<0.001). Conclusions: Positive evidence is emerging for a pleiotropic effect of quercetin intake in patients with T2DM, specifically in terms of anxiety reduction and amelioration of life quality, in just 12 weeks of administration and without adverse effects, indicating clinical safety and underscoring its potential for integration in T2DM supportive care.
C1 [Mantadaki, Aikaterini E.; Vafeiadi, Marina] Univ Crete, Sch Med, Dept Social Med, Iraklion, Greece.
   [Linardakis, Manolis; Anastasiou, Foteini; Symvoulakis, Emmanouil K.] Univ Crete, Sch Med, Dept Social Med, Clin Social & Family Med, Iraklion, Greece.
   [Tsatsakis, Aristidis] Univ Crete, Sch Med, Dept Morphol, Lab Toxicol, Iraklion, Greece.
C3 University of Crete; University of Crete; University of Crete
RP Mantadaki, AE (corresponding author), Univ Crete, Sch Med, Dept Social Med, Iraklion, Greece.
EM aikaterini.mantadaki@gmail.com
RI Vafeiadi, Marina/I-8387-2019; Tsatsakis, Aristidis/H-2890-2013;
   Linardakis, Manolis/T-8147-2019; Mantadaki, Aikaterini/IVH-6524-2023
OI Mantadaki, Aikaterini/0000-0002-6160-8066
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NR 91
TC 4
Z9 4
U1 0
U2 2
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
EI 2168-8184
J9 CUREUS J MED SCIENCE
JI Cureus J Med Sci
PD APR 14
PY 2024
VL 16
IS 4
AR e58219
DI 10.7759/cureus.58219
PG 17
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA QP9K9
UT WOS:001222189900029
PM 38745810
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Rouch, I
   Achour-Crawford, E
   Roche, F
   Castro-Lionard, C
   Laurent, B
   Assoumou, GN
   Gonthier, R
   Barthelemy, JC
   Trombert, B
AF Rouch, I.
   Achour-Crawford, E.
   Roche, F.
   Castro-Lionard, C.
   Laurent, B.
   Assoumou, G. Ntougou
   Gonthier, R.
   Barthelemy, J. -C.
   Trombert, B.
TI Seven-year predictors of self-rated health and life satisfaction in the
   elderly: The proof study
SO JOURNAL OF NUTRITION HEALTH & AGING
LA English
DT Article
DE Metabolic syndrome; subjective health; quality of life; elderly
ID QUALITY-OF-LIFE; METABOLIC SYNDROME; COGNITIVE FUNCTION; DEPRESSION;
   ASSOCIATIONS; PERFORMANCE; MORTALITY; ANXIETY; IMPACT; AGE
AB To investigate the relationship between cognitive performance, affective state, metabolic syndrome and 7-year follow-up self-rated health (SRH) and perceived life satisfaction (PLS).
   Analysis of a prospective cohort study.
   The PROOF study, including 1011 elderly community residents.
   Six hundred and fifty seven subjects completed metabolic syndrome (Met S) variables, neuropsychological and affective measurements at baseline, and then returned a 7-year follow-up questionnaire which included SRH and PLS.
   The prospective association between cognitive function, Met S and each of its components, and affective disorders and subsequent subjective health and quality of life was examined. Covariates included educational level and use of tobacco. The analyses were made in men and women separately.
   In multivariate models, the presence of Met S was significantly associated to weaker SRH (OR = 2.78, p = 0.009 in men and OR = 2.0, p = 0.02 in women). Higher triglycerides rate were associated with weaker SRH in men (OR = 2.23, p = 0.002) and higher fasting glucose in women (OR = 2.54, p = 0.006). Global Met S and abdominal obesity was significantly associated to weaker PLS in women only (respectively OR = 2.70, p = 0.0002 and OR = 1.9, p = 0.02). Depressive symptoms were significantly associated to both weaker SRH and PLS in men (OR = 1.30, p = 0.002; OR = 1.44, p < 0.0001 for SRH and PLS respectively) and in woman (OR = 1.09, p = 0.04; OR = 1.26, p < 0.0001 for SRH and PLS respectively). Anxiety was linked to both weaker SRH and PLS in women (OR = 1.17, p = 0.002 and OR = 1.11, p = 0.03 for SRH and PLS respectively). Finally, lower executive function was associated with weaker PLS in men (OR = 0.43, p = 0.0005).
   metabolic syndrome and certain of its components, anxiety and depressive symptoms, are independent predictors of poorer subjective health and quality of life as assessed over a period of 7 years in a population of a non-demented aging community. Moreover, executive performance was linked to subsequent quality of life in men. Many of these factors being treatable, our findings point to the necessity of providing preventive care strategies by the management of cardiovascular risk factors and anxio-depressive symptoms.
C1 [Rouch, I.; Laurent, B.] Univ Hosp St Etienne, Neurol Unit, F-42055 St Etienne, France.
   [Rouch, I.] Univ Hosp Lyon, Charpennes Hosp, Geriatr Unit, F-69100 Villeurbanne, France.
   [Achour-Crawford, E.; Castro-Lionard, C.; Gonthier, R.] Univ Hosp St Etienne, Geriatr Unit, F-42055 St Etienne, France.
   [Achour-Crawford, E.; Roche, F.; Assoumou, G. Ntougou; Barthelemy, J. -C.; Trombert, B.] PRES Lyon, EA SNA EPIS, F-42055 St Etienne, France.
   [Roche, F.; Assoumou, G. Ntougou; Barthelemy, J. -C.] Univ Hosp St Etienne, Clin & Exercise Physiol Lab, F-42055 St Etienne, France.
   [Trombert, B.] Univ Hosp St Etienne, Publ Hlth & Med Informat Unit, F-42055 Saint Etienne, France.
C3 CHU de St Etienne; CHU Lyon; CHU de St Etienne; CHU de St Etienne; CHU
   de St Etienne
RP Rouch, I (corresponding author), Univ Hosp St Etienne, Neurol Unit, F-42055 St Etienne, France.
EM isabelle.rouch@chu-st-etienne.fr
RI Barthelemy, Jean-Claude/AAE-7180-2019
OI Barthelemy, Jean-Claude/0000-0003-4306-7275; Roche,
   Frederic/0000-0001-6115-7958
FU French Ministry of Health (Programmes Hospitaliers de Recherche
   Clinique); Servier Laboratory; AG2R Company; MPCL Mutual Insurance
   Company
FX Financial support for the PROOF study was provided by the French
   Ministry of Health (Programmes Hospitaliers de Recherche Clinique, 1998
   and 2002), Servier Laboratory and the AG2R and MPCL Mutual Insurance
   Companies.
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NR 42
TC 26
Z9 26
U1 0
U2 9
PU SPRINGER FRANCE
PI PARIS
PA 22 RUE DE PALESTRO, PARIS, 75002, FRANCE
SN 1279-7707
EI 1760-4788
J9 J NUTR HEALTH AGING
JI J. Nutr. Health Aging
PD DEC
PY 2014
VL 18
IS 9
BP 840
EP 847
DI 10.1007/s12603-014-0557-6
PG 8
WC Geriatrics & Gerontology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Nutrition & Dietetics
GA AW3LE
UT WOS:000346187400009
PM 25389962
OA hybrid
DA 2025-06-11
ER

PT J
AU Maimaitituerxun, R
   Chen, WH
   Xiang, JS
   Xie, Y
   Kaminga, AC
   Wu, XY
   Chen, LT
   Yang, JZ
   Liu, AZ
   Dai, WJ
AF Maimaitituerxun, Rehanguli
   Chen, Wenhang
   Xiang, Jingsha
   Xie, Yu
   Kaminga, Atipatsa C.
   Wu, Xin Yin
   Chen, Letao
   Yang, Jianzhou
   Liu, Aizhong
   Dai, Wenjie
TI Prevalence of Anxiety and Associated Factors Among Inpatients with Type
   2 Diabetes Mellitus in China: A Cross-Sectional Study
SO PSYCHIATRIC QUARTERLY
LA English
DT Article; Early Access
DE Prevalence; Associated factors; Anxiety; Type 2 diabetes mellitus;
   Inpatients
ID METABOLIC SYNDROME; HOSPITAL ANXIETY; DEPRESSION; SYMPTOMS; OUTCOMES;
   MANAGEMENT; DISORDERS; ADULTS
AB This study aimed to investigate the prevalence of anxiety and its associated factors among inpatients with type 2 diabetes mellitus (T2DM) in China. This study was a cross-sectional study. Inpatients with T2DM admitted to the Endocrinology Department of Xiangya Hospital, Central South University in Hunan Province of China from March 2021 to December 2021 were consecutively included in this study. Participants were interviewed to obtain the data on socio-demographic characteristics, lifestyle characteristics, T2DM-related information, and social support. Anxiety was measured using the Hospital Anxiety and Depression Scale-anxiety subscale by experienced physicians. Multivariable logistic regression analysis was used to estimate the independent contribution of each independent variable to anxiety. A total of 496 inpatients with T2DM were included in this study. The prevalence of anxiety was 21.8% (95% confidence interval [CI]: 18.1%-25.4%). The results of multivariable logistic regression analysis indicated that age of at least 60 (adjusted odd ratio [aOR] = 1.79, 95% CI: 1.04-3.08), and having diabetes specific complications (aOR = 4.78, 95% CI: 1.02-22.44) were risk factors for anxiety, and an educational level of high school or above (aOR = 0.55, 95% CI: 0.31-0.99), regular physical activity (aOR = 0.36, 95% CI: 0.22-0.58), and high social support (aOR = 0.30, 95% CI: 0.17-0.53) were protective factors for anxiety. A predictive model based on these five variables showed good performance (area under the curve = 0.80). Almost one in five inpatients with T2DM suffered from anxiety in China. Age, educational level, regular physical activity, diabetes specific complications, and social support were independently associated with anxiety.
C1 [Maimaitituerxun, Rehanguli; Xie, Yu; Wu, Xin Yin; Liu, Aizhong; Dai, Wenjie] Cent South Univ, Xiangya Sch Publ Hlth, Dept Epidemiol & Hlth Stat, Changsha, Hunan, Peoples R China.
   [Maimaitituerxun, Rehanguli; Xie, Yu; Wu, Xin Yin; Liu, Aizhong; Dai, Wenjie] Hunan Prov Key Lab Clin Epidemiol, Changsha, Hunan, Peoples R China.
   [Chen, Wenhang] Cent South Univ, Xiangya Hosp, Dept Nephrol, Changsha, Hunan, Peoples R China.
   [Xiang, Jingsha] Shandong First Med Univ, Cent Hosp, Dept Human Resources, Jinan, Shandong, Peoples R China.
   [Kaminga, Atipatsa C.] Mzuzu Univ, Dept Math & Stat, Mzuzu, Malawi.
   [Chen, Letao] Cent South Univ, Xiangya Hosp, Infect Control Ctr, Changsha, Hunan, Peoples R China.
   [Yang, Jianzhou] Changzhi Med Coll, Dept Prevent Med, Changzhi, Shanxi, Peoples R China.
C3 Central South University; Central South University; Shandong First
   Medical University & Shandong Academy of Medical Sciences; Central South
   University; Changzhi Medical College
RP Dai, WJ (corresponding author), Cent South Univ, Xiangya Sch Publ Hlth, Dept Epidemiol & Hlth Stat, Changsha, Hunan, Peoples R China.; Dai, WJ (corresponding author), Hunan Prov Key Lab Clin Epidemiol, Changsha, Hunan, Peoples R China.
EM m18673965791@163.com
RI chen, changhan/K-6713-2018; Liu, aizhong/F-1770-2010
OI Dai, Wenjie/0000-0002-0922-7223; Xie, Yu/0009-0004-5728-4232
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NR 45
TC 2
Z9 2
U1 0
U2 8
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0033-2720
EI 1573-6709
J9 PSYCHIAT QUART
JI Psychiatr. Q.
PD 2023 JUN 30
PY 2023
DI 10.1007/s11126-023-10040-z
EA JUN 2023
PG 13
WC Psychiatry
WE Social Science Citation Index (SSCI)
SC Psychiatry
GA K6TU5
UT WOS:001017753000001
PM 37389720
DA 2025-06-11
ER

PT J
AU Hornik, B
   Dulawa, J
   Durmala, J
AF Hornik, Beata
   Dulawa, Jan
   Durmala, Jacek
TI Metabolic Syndrome and Psychological Effects of Exercise in Hemodialysis
   Patients
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Article
DE metabolic syndrome; hemodialysis; physical activity; anxiety;
   rehabilitation
ID STAGE RENAL-DISEASE; BODY-MASS INDEX; PHYSICAL-ACTIVITY; MAINTENANCE
   HEMODIALYSIS; AEROBIC EXERCISE; CORONARY-ARTERY; BIDIRECTIONAL
   ASSOCIATION; MENTAL-DISORDERS; PRIMARY-CARE; RISK-FACTORS
AB Metabolic syndrome (MS) and anxiety disorders are common problems among hemodialysis patients (HD). However, there have been no studies defining the role of physical activity in reducing anxiety in HD patients with MS. This study was aimed to determine the effects on the severity of anxiety of a four-week rehabilitation program for HD patients, with or without metabolic syndrome (MS), planned and adapted to their abilities. The study was single-center, interventional, non-randomized, and prospective. Fifty-eight individuals completed the project (28 HD patients and 30 controls (C) with normal kidney function). Each group was divided into two subgroups with respect to MS. The mean age of the subjects in the HD and C groups was 56.9 & PLUSMN; 13.3 years (x over bar & PLUSMN; SD) and 61.5 & PLUSMN; 8.3 years (x over bar & PLUSMN; SD), respectively. Planned and adapted to the patient's abilities, the rehabilitation program based on physiotherapy was provided to each subject for 4 weeks. Baseline and post-intervention determined anxiety levels using the State-Trait Anxiety Inventory (STAI). The X1 scale tests state anxiety, and the X2 scale tests trait anxiety. Post-intervention, there was no significant difference in the intensity of state anxiety observed in HD patients compared to C with normal renal function, as observed before the program. After four weeks of regular physical activity planned and adapted to the patient's abilities in an inpatient ward, the level of state anxiety (X1) and trait anxiety (X2) lowered considerably in all HD patients (respectively: 35.1 & PLUSMN; 8.0 vs. 29.2 & PLUSMN; 5.0, p = 0.001 for X1 and 41.8 & PLUSMN; 9.1 vs. 38.1 & PLUSMN; 5.9, p = 0.008 for X2). The rehabilitation program significantly reduced the intensity of state anxiety (X1) in HD patients with MS (35.8 & PLUSMN; 7.9 vs. 29.2 & PLUSMN; 5.1; p = 0.01). The rehabilitation program helped to significantly reduce the intensity of trait anxiety (X2) in HD patients without MS (41.9 & PLUSMN; 10.7 vs. 36.9 & PLUSMN; 5.9; p = 0.04). Four-week physical activity planned and adapted to the patient's abilities reduces the intensity of anxiety in HD patients and controls with normal renal function. HD patients with MS benefit more in terms of reducing perceived state anxiety, and HD patients without MS in terms of reducing trait anxiety.
C1 [Hornik, Beata] Med Univ Silesia, Sch Hlth Sci Katowice, Dept Internal Nursing, PL-40752 Katowice, Poland.
   [Dulawa, Jan] Med Univ Silesia, Sch Hlth Sci Katowice, Dept Internal Med & Metab Dis, PL-40752 Katowice, Poland.
   [Dulawa, Jan] Diaverum, PL-40635 Katowice, Poland.
   [Durmala, Jacek] Med Univ Silesia, Sch Hlth Sci Katowice, Dept Rehabil, PL-40752 Katowice, Poland.
C3 Medical University of Silesia; Medical University of Silesia; Medical
   University of Silesia
RP Hornik, B (corresponding author), Med Univ Silesia, Sch Hlth Sci Katowice, Dept Internal Nursing, PL-40752 Katowice, Poland.
EM bhornik@sum.edu.pl; jdulawa@sum.edu.pl; jdurmala@sum.edu.pl
RI Hornik, Beata/IUM-4231-2023
OI DULAWA, JAN/0000-0002-2230-9258; Durmala, Jacek/0000-0002-0763-7106;
   Hornik, Beata/0000-0002-0106-9216
FU Medical University of Silesia in Katowice
FX This project was supported by a Medical University of Silesia in
   Katowice grant to statutory work (Contract KNW-1-035/N/8/Z).
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NR 81
TC 0
Z9 1
U1 1
U2 7
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD NOV
PY 2021
VL 18
IS 22
AR 11952
DI 10.3390/ijerph182211952
PG 16
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA XE5MS
UT WOS:000723432200001
PM 34831708
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Bayram, P
   Billur, D
   Kizil, S
   Caliskan, H
   Can, B
AF Bayram, Pinar
   Billur, Deniz
   Kizil, Sule
   Caliskan, Hasan
   Can, Belgin
TI Alterations in hippocampal neurogenesis and hippocampal insulin
   signaling pathway in rat with metabolic syndrome
SO IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
LA English
DT Article
DE Behavior tests; Hippocampus; Immunohistochemistry; Insulin; Metabolic
   syndrome; Neurogenesis
ID RESISTANCE; DIFFERENTIATION; TRANSLOCATION; RECEPTOR; MODEL
AB Objective(s): We aimed to examine the level of hippocampal neurogenesis, and assess learning and anxiety and the level of some proteins involving insulin signaling pathways in rats with Metabolic Syndrome (MetS); and to reveal the relationship among them.
   Materials and Methods: Totally, 30 Wistar-albino rats were used. The rats were divided into three groups: Control, MetS, and MetS+Ins. Immunohistochemical staining was performed to evaluate the levels of neurogenesis markers; Doublecortin (DCX), Neuronal-Differentiation-1 (NeuroD1), Ki67, and Neuronal nuclear protein (NeuN). Then, cleaved caspase-3 and TUNEL labeling were performed to detect the level of apoptosis. Additionally, behavior tests were performed to evaluate the learningmemory levels and anxiety-like behaviors. Insulin, Insulin Receptor (IR), Insulin Receptor Substrate (IRS2), glucose transporter (GLUT)-3, and GLUT4 protein expression levels were analyzed to evaluate the possible changes in the insulin signaling pathway.
   Results: An increase in anxiety with memory deficiency was observed in MetS. In the hippocampus of MetS, an increase was detected in the level of apoptosis, whereas a decrease was detected in the expression level of the neurogenesis marker. Insulin secretion and IR levels decreased in hippocampal neurons. We observed that GLUT3 and GLUT4 levels increased because of the non-activated insulin signaling pathway.
   Conclusion: We think that the insulin signaling pathway may have an effect on the decreased neurogenesis in the MetS group. So, the evaluation of the Mitogen-activated protein kinase (MAPK) pathway and the investigation of the effect of endoplasmic reticulum stress on this pathway will be among the targets of our future studies.
C1 [Bayram, Pinar] Kafkas Univ, Fac Med, Dept Histol & Embryol, TR-36100 Kars, Turkey.
   [Billur, Deniz; Can, Belgin] Ankara Univ, Fac Med, Dept Histol & Embryol, Ankara, Turkey.
   [Kizil, Sule] Lokman Hekim Univ, Fac Med, Dept Histol & Embryol, Ankara, Turkey.
   [Caliskan, Hasan] Balikesir Univ, Fac Med, Dept Physiol, Balikesir, Turkey.
C3 Kafkas University; Ankara University; Lokman Hekim University; Balikesir
   University
RP Bayram, P (corresponding author), Kafkas Univ, Fac Med, Dept Histol & Embryol, TR-36100 Kars, Turkey.
EM pinar.bayram@yandex.com
RI Kızıl, Şule/AAZ-4746-2021; Çalışkan, Hasan/HZL-4632-2023; Bayram,
   Pınar/JCE-1678-2023; Billur, Deniz/N-4933-2018
FU Scientific Research Project Council, Ankara University, Turkey
   [16L0230007]
FX The results presented in this paper were part of a student thesis.
   Additionally, the current study was supported by the Scientific Research
   Project Council, Ankara University, Turkey (project number: 16L0230007).
CR Akdas S, 2020, BIOL TRACE ELEM RES, V198, P16, DOI 10.1007/s12011-020-02046-6
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NR 36
TC 7
Z9 7
U1 1
U2 5
PU MASHHAD UNIV MED SCIENCES
PI MASHHAD
PA VICE-CHANCELLOR FOR RES CTR OFF IJBMS, DANESHGAH ST, PO BOX 9138813944 -
   445, MASHHAD, 00000, IRAN
SN 2008-3866
EI 2008-3874
J9 IRAN J BASIC MED SCI
JI Iran. J. Basic Med. Sci.
PD NOV
PY 2022
VL 25
IS 11
BP 1308
EP 1316
DI 10.22038/IJBMS.2022.64917.14295
PG 9
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA 8M2BT
UT WOS:000924277300004
PM 36474571
DA 2025-06-11
ER

PT J
AU Lemche, AV
   Chaban, OS
   Lemche, E
AF Lemche, A. V.
   Chaban, O. S.
   Lemche, E.
TI Depression contributing to dyslipidemic cardiovascular risk in the
   metabolic syndrome
SO JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
LA English
DT Article
DE Metabolic syndrome; Triglycerides; Biomarkers; Zung Self-Rating
   Depression Scale; Structural equation modeling; National sample;
   Cross-sectional design; Cohort studies; SCORE
ID DISEASE RISK; SYMPTOMS; ASSOCIATION; PEOPLE; METAANALYSIS; PREDICTORS;
   MANAGEMENT; MORBIDITY; MORTALITY; EVENTS
AB Purpose Triglycerides are considered an emerging risk factor for cardiovascular mortality. Recent evidence relating depression and metabolic syndrome (MetS) implicated triglyceride levels. We thus investigated interrelations of self-reported depression severity (Zung) and MetS-related biological measures with CVD risk estimates in MetS patients.
   Methods N = 101 patients fulfilling International Diabetes Federation criteria for MetS from a nationwide sampled treatment cohort for MetS with familial T2DM risk or manifest T2DM in a Ukrainian governmental health care system were participants. Both laboratory and non-laboratory measures were included. Recent European cardiological SCORE system CVD risk estimates were used as outcome variables.
   Results Following correlation matrix, we entered all variables into principal component analysis (PCA; 76.7% explained variance), followed by hierarchical regression and structural equation modeling (SEM). The PCA suggested a one-factor solution, where the latent variable showed highest loadings of SCORE risk estimates, triglycerides, depression severity, and pulse pressure. A comprehensive SEM was adjusted with 92.7% explained variance: overall CVD risk related to depression, pulse pressure, triglycerides, and fasting glucose.
   Conclusion The findings in this MetS sample suggest that triglycerides and depression severity are the key variables among MetS biomarkers in cross-sectionally associating with the fatal and total SCORE risk estimates in MetS.
C1 [Lemche, A. V.] Inst Clin Res, Berlin, Germany.
   [Chaban, O. S.] Bogomolets Natl Med Univ, Sect Psychosomat Med, Kiev, Ukraine.
   [Lemche, E.] Kings Coll London, Inst Psychiat Psychol & Neurosci, Sect Cognit Neuropsychiat, Box PO 69,De Crespigny Pk, London SE5 8AF, England.
C3 Bogomolets National Medical University; University of London; King's
   College London
RP Lemche, E (corresponding author), Kings Coll London, Inst Psychiat Psychol & Neurosci, Sect Cognit Neuropsychiat, Box PO 69,De Crespigny Pk, London SE5 8AF, England.
EM alexandra.lemche@ikf-berlin.de; chol@i.ua; erwin.lemche@kcl.ac.uk
RI Chaban, Oleg/ABA-8319-2020
OI Chaban, Oleg/0000-0001-9702-7629
FU National Medical University of the Ukraine, Kiev; Ministry of Public
   Health of the Ukraine
FX A.V.L. acknowledges intramural funding from the National Medical
   University of the Ukraine, Kiev. O.S.C. was supported by a center grant
   on "Quality of Life in Diabetes" from the Ministry of Public Health of
   the Ukraine. The funders had no role whatsoever in design, analyses, or
   manuscript preparation.
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NR 42
TC 9
Z9 9
U1 0
U2 5
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0391-4097
EI 1720-8386
J9 J ENDOCRINOL INVEST
JI J. Endocrinol. Invest.
PD MAY
PY 2017
VL 40
IS 5
BP 539
EP 546
DI 10.1007/s40618-016-0601-y
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism
GA ES1RZ
UT WOS:000399306000011
PM 28012071
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Rao, FW
   Zhang, KX
   Khandrika, S
   Mahata, M
   Fung, MM
   Ziegler, MG
   Rana, BK
   O'Connor, DT
AF Rao, Fangwen
   Zhang, Kuixing
   Khandrika, Srikrishna
   Mahata, Manjula
   Fung, Maple M.
   Ziegler, Michael G.
   Rana, Brinda K.
   O'Connor, Daniel T.
TI Isoprostane, an "Intermediate Phenotype" for Oxidative Stress
   Heritability, Risk Trait Associations, and the Influence of Chromogranin
   B Polymorphism
SO JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
LA English
DT Article
DE catecholamine; CHGB; hypertension; isoprostane excretion; metabolic
   syndrome; oxidative stress; twin study
ID HYDROGEN-PEROXIDE PRODUCTION; CORONARY-ARTERY-DISEASE; AU-RICH ELEMENTS;
   LIPID-PEROXIDATION; IN-VIVO; F-2 ALPHA; ENDOTHELIAL DYSFUNCTION;
   ESSENTIAL-HYPERTENSION; NAD(P)H OXIDASE; FAMILY-HISTORY
AB Objectives The purpose of this study is to understand whether isoprostane, a biomarker of oxidative stress, is subject to heritable control; whether it shares heritability with other cardiometabolic risk traits; and finally whether genetic variation at a specific candidate locus contributes to isoprostane variability.
   Background Isoprostane marks oxidative stress, and elevated isoprostane excretion might be involved in cardiovascular target organ damage. Here we used the classical twin pair method to probe the role of heredity in generating the isoprostane trait.
   Methods Trait heritability (h(2)) and shared genetic determination among traits (pleiotropy, genetic covariance, rho(G)) were estimated by variance components in twin pairs. Because the isoprostane and Chromogranin B (CHGB) traits shared rho(G), we examined the CHGB locus for effects on the traits.
   Results Urinary isoprostane excretion was substantially heritable (h(2) = 65.8 +/- 4.3%), and the isoprostane trait aggregated with multiple traits (CHGB, catecholamines, autonomic/baroreceptor, and renal function), including several features of the metabolic syndrome (body mass index, insulin resistance, dyslipidemia). Isoprostane excretion also aggregated with systemic hypertension. Twin studies demonstrated genetic covariance (pleiotropy) for the isoprostane and CHGB traits (rho(G) = 0.27), and therefore we investigated the CHGB locus for trait effects. A common variant in the 3'-UTR of CHGB (C + 84A) associated with plasma CHGB as well as isoprostane excretion. The C + 84A disrupted an A/U-rich messenger ribonucleic acid stability element, and in transfected luciferase/3'-UTR plasmids, the C + 84 and +84A alleles differed markedly in reporter expression in chromaffin and neuroblastoma cells, whereas site-directed mutagenesis confirmed the importance of this variant within the context of the A/U-rich motif.
   Conclusions Isoprostane excretion is substantially heritable and shares joint genetic determination with CHGB as well as multiple features of the metabolic syndrome. A common polymorphism in the 3'-UTR (C + 84A) of CHGB, which disrupts an A/U-rich messenger ribonucleic acid stability element, associates with not only CHGB secretion but also excretion of isoprostane. We propose a chain of events whereby CHGB genetic variation results in oxidative stress, with isoprostane formation. The results suggest novel links among the catecholaminergic system, oxidative pathways, and systemic hypertension. (J Am Coll Cardiol 2010;56:1338-50) (C) 2010 by the American College of Cardiology Foundation
C1 Univ Calif San Diego, Dept Med, San Diego, CA 92103 USA.
   Univ Calif San Diego, Dept Pharmacol, San Diego, CA 92103 USA.
   Univ Calif San Diego, Inst Genom Med, San Diego, CA 92103 USA.
   VA San Diego Healthcare Syst, San Diego, CA USA.
C3 University of California System; University of California San Diego;
   University of California System; University of California San Diego;
   University of California System; University of California San Diego; US
   Department of Veterans Affairs; Veterans Health Administration (VHA); VA
   San Diego Healthcare System
RP O'Connor, DT (corresponding author), Univ Calif San Diego, Sch Med, Dept Med 0838, 9500 Gilman Dr, La Jolla, CA 92093 USA.
EM doconnor@ucsd.edu
RI Ziegler, Michael/L-4728-2019
FU National Institutes of Health (NIH); Department of Veterans Affairs;
   NIH/National Center for Research Resources [RR00827]; NIH/National
   Center on Minority Health and Health Disparities Excellence in
   Partnerships for Community Outreach, Research on Health Disparities and
   Training/Center to Reduce Cancer Health Disparities minority health
   center [MD000220]
FX This work was supported by grants from the National Institutes of Health
   (NIH) and the Department of Veterans Affairs. The authors appreciate the
   assistance of the NIH/National Center for Research Resources-supported
   General Clinical Research Center at University of California at San
   Diego (RR00827) and the NIH/National Center on Minority Health and
   Health Disparities Excellence in Partnerships for Community Outreach,
   Research on Health Disparities and Training/Center to Reduce Cancer
   Health Disparities minority health center (MD000220). Dr. Fung has an
   investigator-initiated trial with Forest Laboratories. All other authors
   have reported that they have no relationships to disclose. Drs. Rao and
   Zhang contributed equally to this work. Stephen Nicholls, MD, served as
   Guest Editor for this paper.
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NR 64
TC 11
Z9 12
U1 1
U2 5
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0735-1097
J9 J AM COLL CARDIOL
JI J. Am. Coll. Cardiol.
PD OCT 12
PY 2010
VL 56
IS 16
BP 1338
EP 1350
DI 10.1016/j.jacc.2010.03.092
PG 13
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 656VW
UT WOS:000282370200010
PM 20888525
OA Bronze
DA 2025-06-11
ER

PT J
AU Jääskeläinen, T
   Knekt, P
   Suvisaari, J
   Männistö, S
   Partonen, T
   Sääksjärvi, K
   Kaartinen, NE
   Kanerva, N
   Lindfors, O
AF Jaeaeskelaeinen, Tuija
   Knekt, Paul
   Suvisaari, Jaana
   Maennistoe, Satu
   Partonen, Timo
   Saeaeksjaervi, Katri
   Kaartinen, Niina E.
   Kanerva, Noora
   Lindfors, Olavi
TI Higher serum 25-hydroxyvitamin D concentrations are related to a reduced
   risk of depression
SO BRITISH JOURNAL OF NUTRITION
LA English
DT Article
DE Vitamin D; Depression; Cross-sectional studies
ID COMPREHENSIVE DEVELOPMENTAL MODEL; FOOD FREQUENCY QUESTIONNAIRE;
   VITAMIN-D SUPPLEMENTATION; MAJOR DEPRESSION; PARATHYROID-HORMONE;
   GENERAL-POPULATION; MENTAL-DISORDERS; OLDER WOMEN; DISEASE; SYMPTOMS
AB Vitamin D has been suggested to protect against depression, but epidemiological evidence is scarce. The present study investigated the relationship of serum 25-hydroxyvitamin D (25(OH)D) with the prevalence of depressive and anxiety disorders. The study population consisted of a representative sample of Finnish men and women aged 30-79 years from the Health 2000 Survey. The sample included 5371 individuals, of which 354 were diagnosed with depressive disorder and 222 with anxiety disorder. Serum 25(OH)D concentration was determined from frozen samples. In a cross-sectional study, a total of four indicators of depression and one indicator of anxiety were used as dependent variables. Serum 25(OH)D was the risk factor of interest, and logistic models used further included sociodemographic and lifestyle variables as well as indicators of metabolic health as confounding and/or effect-modifying factors. The population attributable fraction (PAF) was estimated. Individuals with higher serum 25(OH)D concentrations showed a reduced risk of depression. The relative odds between the highest and lowest quartiles was 0.65 (95% CI 0.46, 0.93; P for trend=0.006) after adjustment for sociodemographic, lifestyle and metabolic factors. Higher serum 25(OH)D concentrations were associated with a lower prevalence of depressive disorder especially among men, younger, divorced and those who had an unhealthy lifestyle or suffered from the metabolic syndrome. The PAF was estimated to be 19% for depression when serum 25(OH)D concentration was at least 50nmol/l. These results support the hypothesis that higher serum 25(OH)D concentrations protect against depression even after adjustment for a large number of sociodemographic, lifestyle and metabolic factors. Large-scale prospective studies are needed to confirm this finding.
C1 [Jaeaeskelaeinen, Tuija; Knekt, Paul; Suvisaari, Jaana; Maennistoe, Satu; Partonen, Timo; Saeaeksjaervi, Katri; Kaartinen, Niina E.; Kanerva, Noora; Lindfors, Olavi] Natl Inst Hlth & Welf, Helsinki 00271, Finland.
C3 Finland National Institute for Health & Welfare
RP Knekt, P (corresponding author), Natl Inst Hlth & Welf, POB 30, Helsinki 00271, Finland.
EM paul.knekt@thl.fi
RI Jääskeläinen, Tuija/HJP-9606-2023; Kaartinen, Niina/AAZ-8585-2020;
   Partonen, Timo/G-1105-2012
OI Mannisto, Satu/0000-0002-8668-3046; Kanerva, Noora/0000-0001-6776-9357;
   Suvisaari, Jaana/0000-0001-7167-0990; Saaksjarvi,
   Katri/0000-0002-5061-4911; Partonen, Timo/0000-0003-1951-2455
FU Academy of Finland [138876]; Yrjo Jahnsson Foundation; Juho Vainio
   Foundation
FX The present study was financially supported by the Academy of Finland
   (grant no. 138876), the Yrjo Jahnsson Foundation and the Juho Vainio
   Foundation.
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NR 51
TC 38
Z9 40
U1 0
U2 18
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1145
EI 1475-2662
J9 BRIT J NUTR
JI Br. J. Nutr.
PD MAY 14
PY 2015
VL 113
IS 9
BP 1418
EP 1426
DI 10.1017/S0007114515000689
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA CJ1ZN
UT WOS:000355283800009
PM 25989997
OA Bronze
DA 2025-06-11
ER

PT J
AU Rudolf, S
   Greggersen, W
   Kahl, KG
   Hüppe, M
   Schweiger, U
AF Rudolf, Sebastian
   Greggersen, Wiebke
   Kahl, Kai Gustav
   Hueppe, Michael
   Schweiger, Ulrich
TI Elevated IL-6 levels in patients with atypical depression but not in
   patients with typical depression
SO PSYCHIATRY RESEARCH
LA English
DT Article
DE Mood disorder; Metabolic syndrome; Neuroimmunomodulation; Cytokines
ID CORONARY-HEART-DISEASE; PITUITARY-ADRENAL AXIS; METABOLIC SYNDROME;
   INFLAMMATORY MARKERS; INSULIN SENSITIVITY; MAJOR DEPRESSION;
   INTERLEUKIN-6; MORTALITY; SYMPTOMS; DISORDER
AB Elevated levels of the proinflammatoty cytokine Interleukin-6 (IL-6) are among the most consistent findings in patients with major depressive disorder (MDD). Additionally, some evidence suggests that elevated cytokine levels in patients with major depression are responsible for the development of metabolic syndrome in patients suffering from MDD. Therefore, the aim of the study was to examine the concentrations of IL-6 in specific subtypes of MDD and to investigate their relationship to metabolic factors. Twenty-four patients with typical (24) and atypical (eight) major depression according to DSM-IV criteria were studied and compared to 24 normal controls. Blood samples were collected during a stepwise glucose-clamp procedure, and IL-6 concentrations were measured by high sensitivity ELISA. IL-6 levels were elevated in patients suffering from atypical depression but not in patients with typical depression, compared to normal controls. IL-6 correlated significantly with HbA1c, insulin, waist girth, BMI, number of alcoholic drinks per week and C-reactive protein. Our data indicate that high concentrations of IL-6 during the glucose clamp may be limited to the atypical subgroup of patients with MDD. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
C1 [Rudolf, Sebastian; Greggersen, Wiebke; Schweiger, Ulrich] Med Univ Lubeck, Sch Med, Dept Psychiat, D-23538 Lubeck, Germany.
   [Kahl, Kai Gustav] Hannover Med Sch, Dept Psychiat Social Psychiat & Psychotherapy, Hannover, Germany.
   [Hueppe, Michael] Med Univ Lubeck, Sch Med, Dept Anaesthesiol, D-23538 Lubeck, Germany.
C3 University of Lubeck; Hannover Medical School; University of Lubeck
RP Rudolf, S (corresponding author), Med Univ Lubeck, Sch Med, Dept Psychiat, Ratzeburger Allee 160, D-23538 Lubeck, Germany.
EM sebastian.rudolf@psychiatrie.uk-sh.de
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NR 54
TC 57
Z9 60
U1 1
U2 15
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0165-1781
J9 PSYCHIAT RES
JI Psychiatry Res.
PD JUN 30
PY 2014
VL 217
IS 1-2
BP 34
EP 38
DI 10.1016/j.psychres.2014.02.016
PG 5
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA AI2SR
UT WOS:000336708900006
PM 24673855
DA 2025-06-11
ER

PT J
AU Sabbagh, JJ
   O'Leary, JC
   Blair, LJ
   Klengel, T
   Nordhues, BA
   Fontaine, SN
   Binder, EB
   Dickey, CA
AF Sabbagh, Jonathan J.
   O'Leary, John C., III
   Blair, Laura J.
   Klengel, Torsten
   Nordhues, Bryce A.
   Fontaine, Sarah N.
   Binder, Elisabeth B.
   Dickey, Chad A.
TI Age-Associated Epigenetic Upregulation of the FKBP5 Gene Selectively
   Impairs Stress Resiliency
SO PLOS ONE
LA English
DT Article
ID PROTEIN 51 FKBP5; GLUCOCORTICOID-RECEPTOR; CHRONIC CORTICOSTERONE;
   DEPRESSIVE SYMPTOMS; IMMUNOPHILIN FKBP51; ALZHEIMERS-DISEASE; METABOLIC
   SYNDROME; MAJOR DEPRESSION; DISORDERS; RATS
AB Single nucleotide polymorphisms (SNPs) in the FK506 binding protein 5 (FKBP5) gene combine with traumatic events to increase risk for post-traumatic stress and major depressive disorders (PTSD and MDD). These SNPs increase FKBP51 protein expression through a mechanism involving demethylation of the gene and altered glucocorticoid signaling. Aged animals also display elevated FKBP51 levels, which contribute to impaired resiliency to depressive-like behaviors through impaired glucocorticoid signaling, a phenotype that is abrogated in FKBP5 2/2 mice. But the age of onset and progressive stability of these phenotypes remain unknown. Moreover, it is unclear how FKBP5 deletion affects other glucocorticoid-dependent processes or if age-associated increases in FKBP51 expression are mediated through a similar epigenetic process caused by SNPs in the FKBP5 gene. Here, we show that FKBP51-mediated impairment in stress resiliency and glucocorticoid signaling occurs by 10 months of age and this increased over their lifespan. Surprisingly, despite these progressive changes in glucocorticoid responsiveness, FKBP5 2/2 mice displayed normal longevity, glucose tolerance, blood composition and cytokine profiles across lifespan, phenotypes normally associated with glucocorticoid signaling. We also found that methylation of Fkbp5 decreased with age in mice, a process that likely explains the age-associated increases in FKBP51 levels. Thus, epigenetic upregulation of FKBP51 with age can selectively impair psychological stress-resiliency, but does not affect other glucocorticoid-mediated physiological processes. This makes FKBP51 a unique and attractive therapeutic target to treat PTSD and MDD. In addition, aged wild-type mice may be a useful model for investigating the mechanisms of FKBP5 SNPs associated with these disorders.
C1 [Sabbagh, Jonathan J.; O'Leary, John C., III; Blair, Laura J.; Nordhues, Bryce A.; Fontaine, Sarah N.; Dickey, Chad A.] Univ S Florida, Byrd Alzheimers Res Inst, Dept Mol Med, Tampa, FL 33620 USA.
   [Klengel, Torsten; Binder, Elisabeth B.] Emory Univ, Sch Med, Dept Psychiat & Behav Sci, Atlanta, GA USA.
   [Klengel, Torsten; Binder, Elisabeth B.] Max Planck Inst Psychiat, Dept Translat Res, D-80804 Munich, Germany.
C3 State University System of Florida; University of South Florida; Emory
   University; Max Planck Society
RP Dickey, CA (corresponding author), Univ S Florida, Byrd Alzheimers Res Inst, Dept Mol Med, Tampa, FL 33620 USA.
EM cdickey@health.usf.edu
RI Binder, Elisabeth/K-8905-2014; Fontaine, Sarah/P-6536-2016; Dickey,
   Chad/H-4441-2011; Klengel, Torsten/E-5629-2010
OI Klengel, Torsten/0000-0001-7045-9229; Blair, Laura/0000-0002-4981-5564
FU National Institutes of Health/National Institutes of Neurological
   Disease and Stroke [R01 NS073899]; American Federation for Aging
   Research
FX This work was supported by the National Institutes of Health/National
   Institutes of Neurological Disease and Stroke R01 NS073899 and the
   American Federation for Aging Research. The funders had no role in study
   design, data collection and analysis, decision to publish, or
   preparation of the manuscript.
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NR 44
TC 79
Z9 86
U1 0
U2 26
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD SEP 5
PY 2014
VL 9
IS 9
AR e107241
DI 10.1371/journal.pone.0107241
PG 8
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA AZ1IR
UT WOS:000347993600108
PM 25191701
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Kim, SH
   Chung, JH
   Song, SW
   Jung, WS
   Lee, YA
   Kim, HN
AF Kim, Se-Hong
   Chung, Ju-hye
   Song, Sang-Wook
   Jung, Won Sang
   Lee, Yun-Ah
   Kim, Ha-Na
TI Relationship between deep subcutaneous abdominal adipose tissue and
   metabolic syndrome: a case control study
SO DIABETOLOGY & METABOLIC SYNDROME
LA English
DT Article
DE Superficial subcutaneous adipose tissue; Deep subcutaneous adipose
   tissue; Visceral adipose tissue; Metabolic syndrome; Inflammatory
   cytokine; Adipocytokine
ID VISCERAL FAT ACCUMULATION; TYPE-2 DIABETES-MELLITUS; INSULIN-RESISTANCE;
   OBESE INDIVIDUALS; OXIDATIVE STRESS; ASSOCIATION; ADIPONECTIN;
   EXPRESSION; RISK; MARKERS
AB Background: The deep subcutaneous adipose tissue (dSAT) is closely related to the obesity-associated complications similarly to the characteristics of visceral adipose tissue (VAT). However, the association between dSAT and metabolic syndrome (MS) is unclear. The purpose of our study was to evaluate the association of distinct abdominal adipose tissue with the cardiometabolic risk factors and MS.
   Methods: Abdominal computed tomography (CT) images were obtained in 365 asymptomatic subjects (187 subjects with MS and 178 without MS). The axial images segmented into superficial and deep SAT by manually tracing the fascia superficialis at L4-5 levels. The concentrations of serum inflammatory cytokines and adipokines were also measured.
   Results: The MS group had significantly lower adiponectin levels but significantly higher levels of resistin, leptin, tumor necrosis factor-alpha (TNF-a), interleukin-6 (IL-6), intercellular adhesion molecule (ICAM), monocyte chemotactic protein-1 (MCP-1), and oxLDL than the control group (p < 0.05). All inflammatory cytokines and adipokines were associated with the sum of VAT and dSAT areas (VDAT) (P for trend < 0.05), but no significant correlation was found between inflammatory cytokines and sSAT. dSAT was significantly associated with MS in both men and women (OR 2.371; p < 0.001) whereas the ORs between sSAT and MS were not significant (p = 0.597). The age-adjusted ORs between VDAT and MS (OR of 8.359 in men and 3.183 in women, p < 0.001) were higher than those of VAT (OR of 7.941 in men and 2.570 in women, p < 0.05) and dSAT (OR of 2.954 in men and 1.856 in women, p < 0.05).
   Conclusions: We demonstrated that dSAT was associated with increased inflammation and oxidative stress, suggesting that dSAT is an important determinant of MS. Therefore, abdominal subcutaneous fat should be considered as two functionally distinct compartments rather than a single entity.
C1 [Kim, Se-Hong; Song, Sang-Wook; Lee, Yun-Ah; Kim, Ha-Na] Catholic Univ Korea, St Vincents Hosp, Coll Med, Dept Family Med, 93-6 Ji Dong, Suwon 442723, Kyonggi Do, South Korea.
   [Chung, Ju-hye] Catholic Univ Korea, Coll Med, Uijeongbu St Marys Hosp, Dept Family Med, 271 Cheon Bo Ro, Uijongbu 480717, Gyeonggi Do, South Korea.
   [Jung, Won Sang] Catholic Univ Korea, St Vincents Hosp, Coll Med, Dept Radiol, 93-6 Ji Dong, Suwon 442723, Kyonggi Do, South Korea.
C3 Catholic University of Korea; Catholic University of Korea; Catholic
   University of Korea
RP Chung, JH (corresponding author), Catholic Univ Korea, Coll Med, Uijeongbu St Marys Hosp, Dept Family Med, 271 Cheon Bo Ro, Uijongbu 480717, Gyeonggi Do, South Korea.
EM juana@catholic.ac.kr
RI LEE, YOUNG BOK/AAZ-6426-2021
OI Lee, Yun-Ah/0000-0001-8910-7143
FU Catholic Medical Center Research Foundation [2014-B0001-00007]
FX This work was supported by the Catholic Medical Center Research
   Foundation in the program year of 2014 (2014-B0001-00007).
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NR 40
TC 53
Z9 58
U1 0
U2 14
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1758-5996
J9 DIABETOL METAB SYNDR
JI Diabetol. Metab. Syndr.
PD FEB 12
PY 2016
VL 8
AR 10
DI 10.1186/s13098-016-0127-7
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA DE2SD
UT WOS:000370476300001
PM 26877772
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Révész, D
   Milaneschi, Y
   Verhoeven, JE
   Lin, J
   Penninx, BWJH
AF Revesz, Dora
   Milaneschi, Yuri
   Verhoeven, Josine E.
   Lin, Jue
   Penninx, Brenda W. J. H.
TI Longitudinal Associations Between Metabolic Syndrome Components and
   Telomere Shortening
SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Article
ID INSULIN-RESISTANCE; OXIDATIVE STRESS; STEM-CELLS; LENGTH; AGE;
   INFLAMMATION; OBESITY; DEPRESSION; MORTALITY; PREDICTS
AB Context: Deterioration of metabolic syndrome (MetS) has been associated with short telomere length (TL). Large-scale longitudinal studies with repeated measures of MetS and TL are lacking.
   Objectives: We examined whether baseline MetS components predict TL over time, and whether deteriorations in MetS parallel telomere attrition.
   Design and Setting: Participants were part of The Netherlands Study of Depression and Anxiety, an ongoing prospective cohort study.
   Participants: This study included 1808 participants age 18-65 years.
   Main Outcome Measures: Leukocyte TL (using qPCR) and MetS components (waist circumference, triglycerides, high-density lipoprotein [HDL] cholesterol, systolic blood pressure, and fasting glucose) were determined at baseline and after 6 years. Generalized estimated equation models were used to examine the associations between baseline MetS and TL over time, and linear regressions were used to associate 6-year changes in both MetS components and TL, while adjusting for sociodemographic and lifestyle factors.
   Results: Higher baseline waist circumference (B = -29.7; P = .006) and glucose (B = -26.4; P = .02), and lower HDL (B = 25.5; P = .03) were consistently associated with shorter TL over followup. Greater 6-year increase in waist circumference was associated with larger telomere attrition (B = -41.8; P = .01), and similar but nonsignificant associations were observed for larger increase in triglycerides and glucose levels.
   Conclusions: Metabolic dysregulations are associated with shorter telomeres over two time points. In particular, increasing abdominal adiposity is accompanied by accelerated telomere attrition. Future studies should elucidate underlying mechanisms of this bidirectional relationship and investigate whether targeting obesity may reduce telomere attrition to prevent further deterioration toward cardiovascular and aging-related complications.
C1 [Revesz, Dora; Milaneschi, Yuri; Verhoeven, Josine E.; Penninx, Brenda W. J. H.] Vrije Univ Amsterdam, Med Ctr, EMGO Inst Hlth & Care Inst, Dept Psychiat, NL-1081 HZ Amsterdam, Netherlands.
   [Lin, Jue] Univ Calif San Francisco, Dept Biochem & Biophys, San Francisco, CA 94143 USA.
C3 Vrije Universiteit Amsterdam; University of California System;
   University of California San Francisco
RP Révész, D (corresponding author), POB 74077, NL-1081 HL Amsterdam, Netherlands.
EM d.revesz@ggzingeest.nl
RI Penninx, Brenda/S-7627-2017
OI Milaneschi, Yuri/0000-0002-3697-6617
FU NWO-VICI Grant [91811602]; Geestkracht program of The Netherlands
   Organisation for Health Research and Development (ZonMW) [10-000-1002];
   VU University Medical Center; GGZ in Geest; Arkin; Leiden University
   Medical Center; GGZ Rivierduinen; University Medical Center Groningen;
   Lentis; GGZ Friesland; GGZ Drenthe; IQ Healthcare; Netherlands Institute
   for Health Services Research; Netherlands Institute of Mental Health and
   Addiction
FX The work of D.R., J.E.V., B.W.J.H.P., and telomere length assaying was
   supported through NWO-VICI Grant No. 91811602. The infrastructure for
   the NESDA study (www.nesda.nl) is funded through the Geestkracht program
   of The Netherlands Organisation for Health Research and Development
   (ZonMW, Grant No. 10-000-1002) and is supported by participating
   universities and mental health care organisations (VU University Medical
   Center, GGZ inGeest, Arkin, Leiden University Medical Center, GGZ
   Rivierduinen, University Medical Center Groningen, Lentis, GGZ
   Friesland, GGZ Drenthe, IQ Healthcare, Netherlands Institute for Health
   Services Research, and Netherlands Institute of Mental Health and
   Addiction).
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NR 56
TC 70
Z9 73
U1 2
U2 11
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0021-972X
EI 1945-7197
J9 J CLIN ENDOCR METAB
JI J. Clin. Endocrinol. Metab.
PD AUG
PY 2015
VL 100
IS 8
BP 3050
EP 3059
DI 10.1210/JC.2015-1995
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA CW2XH
UT WOS:000364855900048
PM 26133009
OA Bronze
DA 2025-06-11
ER

PT J
AU Soltani, M
   Hosseinzadeh-Attar, MJ
   Rezaei, M
   Alipoor, E
   Vasheghani-Farahani, A
   Yaseri, M
   Rezayat, SM
AF Soltani, Mitra
   Hosseinzadeh-Attar, Mohammad Javad
   Rezaei, Mahsa
   Alipoor, Elham
   Vasheghani-Farahani, Ali
   Yaseri, Mehdi
   Rezayat, Seyed Mahdi
TI Effect of nano-curcumin supplementation on cardiometabolic risk factors,
   physical and psychological quality of life, and depression in patients
   with coronary slow flow phenomenon: a randomized double-blind clinical
   trial
SO TRIALS
LA English
DT Article
DE Curcumin; Coronary slow flow phenomenon; Cardiometabolic risk factors,
   Quality of life; Depression; Glycemic control
ID C-REACTIVE PROTEIN; TYPE-2 DIABETES-MELLITUS; ADHESION MOLECULES;
   PLACEBO; VISFATIN; GLUCOSE; EFFICACY; MARKERS; CANCER; MODEL
AB Background Extensive evidence has suggested the cardio-protective properties of the polyphenol curcumin. The aim of this study was to investigate the effects of a highly bioavailable curcumin supplement on cardiometabolic risk factors, health-related quality of life, and depression in patients with coronary slow flow phenomenon (CSFP). Methods This randomized double-blind placebo-controlled clinical trial was conducted in 42 patients with CSFP (age 35-70 years, 25 <= body mass index < 40 kg/m(2)). Patients received either 80 mg/day nano-curcumin or placebo for 12 weeks. Serum levels of visfatin, high-sensitivity C-reactive protein (hs-CRP), and glycemic indices were measured before and after the intervention. The short form 36-item quality of life (SF-36) and Beck's Depression Inventory-II (BDI-II) questionnaires were assessed, as well. Results No significant improvements were observed in circulating hs-CRP and visfatin following the intervention. A significant increase was observed in pre- to post-fasting blood glucose (- 0.9 +/- 12.2 vs. 7.7 +/- 12.4 mg/dl, p = 0.02) and hemoglobin A1C (- 0.1 +/- 0.8 vs. 0.5 +/- 0.8%, p = 0.04) levels, in the placebo compared with the intervention group. Physical (8.2 +/- 8.1 vs. - 1.2 +/- 6.5, p < 0.001) and mental (6.8 +/- 11.8 vs. - 1.1 +/- 10.4, p = 0.02) component summary scores were significantly improved in the nano-curcumin than the placebo group. Additionally, the number of patients with lower degrees of depression was significantly better in the intervention than the placebo group following the supplementation (p = 0.046). Conclusion Curcumin supplementation prevented deterioration of glycemic control and improved physical and psychological quality of life and depression in patients with CSFP. Trial registration Iranian Registry of Clinical Trials (IRCT20131125015536N8), June 19, 2019.
C1 [Soltani, Mitra; Hosseinzadeh-Attar, Mohammad Javad; Rezaei, Mahsa; Alipoor, Elham] Univ Tehran Med Sci, Dept Clin Nutr, Sch Nutr Sci & Dietet, Tehran, Iran.
   [Hosseinzadeh-Attar, Mohammad Javad; Vasheghani-Farahani, Ali] Univ Tehran Med Sci, Tehran Heart Ctr, Dept Clin Cardiac Electrophysiol, Tehran, Iran.
   [Alipoor, Elham; Vasheghani-Farahani, Ali] Univ Tehran Med Sci, Cardiovasc Dis Res Inst, Cardiac Primary Prevent Res Ctr, Tehran, Iran.
   [Yaseri, Mehdi] Univ Tehran Med Sci, Sch Publ Hlth, Dept Epidemiol & Biostat, Tehran, Iran.
   [Rezayat, Seyed Mahdi] Univ Tehran Med Sci, Sch Adv Technol Med, Dept Med Nanotechnol, Tehran, Iran.
   [Rezayat, Seyed Mahdi] Univ Tehran Med Sci, Sch Med, Dept Pharmacol, Tehran, Iran.
C3 Tehran University of Medical Sciences; Tehran University of Medical
   Sciences; Tehran University of Medical Sciences; Tehran University of
   Medical Sciences; Tehran University of Medical Sciences; Tehran
   University of Medical Sciences
RP Hosseinzadeh-Attar, MJ (corresponding author), Univ Tehran Med Sci, Dept Clin Nutr, Sch Nutr Sci & Dietet, Tehran, Iran.; Hosseinzadeh-Attar, MJ (corresponding author), Univ Tehran Med Sci, Tehran Heart Ctr, Dept Clin Cardiac Electrophysiol, Tehran, Iran.; Rezayat, SM (corresponding author), Univ Tehran Med Sci, Sch Adv Technol Med, Dept Med Nanotechnol, Tehran, Iran.; Rezayat, SM (corresponding author), Univ Tehran Med Sci, Sch Med, Dept Pharmacol, Tehran, Iran.
EM hosseinzadeh.md.phd@gmail.com; rezayat@sina.tums.ac.ir
RI Yaseri, Mehdi/I-1645-2018; Rezayat, Seyed Mahdi/HHC-7714-2022;
   Hosseinzadeh-Attar, Mohammad Javad/E-9358-2018; Alipoor,
   Elham/ABB-5878-2021
OI Hosseinzadeh-Attar, Mohammad Javad/0000-0002-5787-4089; Alipoor,
   Elham/0000-0002-9463-6354
FU Tehran University of Medical Sciences and Health Services [41111]
FX This study was supported by Tehran University of Medical Sciences and
   Health Services grant 41111
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NR 60
TC 5
Z9 5
U1 2
U2 4
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1745-6215
J9 TRIALS
JI Trials
PD JUL 31
PY 2024
VL 25
IS 1
AR 515
DI 10.1186/s13063-024-08354-9
PG 12
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA A4G3J
UT WOS:001282126700003
PM 39085864
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Ippoliti, F
   Canitano, N
   Businaro, R
AF Ippoliti, Flora
   Canitano, Nicoletta
   Businaro, Rita
TI Stress and Obesity as Risk Factors in Cardiovascular Diseases: A
   Neuroimmune Perspective
SO JOURNAL OF NEUROIMMUNE PHARMACOLOGY
LA English
DT Article
DE Stress; Immune system; Obesity; Insulin; Adipokines; Cardiovascular
   diseases
ID EPICARDIAL ADIPOSE-TISSUE; CORONARY-HEART-DISEASE; METABOLIC-SYNDROME;
   MYOCARDIAL-INFARCTION; INSULIN-RESISTANCE; INTERFERON-GAMMA; EATING
   BEHAVIOR; NEUROPEPTIDE-Y; IMMUNE-SYSTEM; T-CELLS
AB Obesity is now growing at an alarming rate reaching epidemic proportions worldwide thus increasing morbidity and mortality rates for chronic disease. But although we have ample information on the complications associated with obesity, precisely what causes obesity remains poorly understood. Some evidence attributes a major role to a low-grade chronic inflammatory state (neurogenic inflammation) induced in obesity by inflammatory mediators produced and secreted within the expanded activated adipocyte pool. Adipose tissue is an endocrine organ that secretes numerous adipose tissue-specific or enriched hormones, known as adipokines, cytokine-like molecules thought to play a pathogenic role in cardiovascular diseases. The imbalance between increased inflammatory stimuli and decreased anti-inflammatory mechanisms may depend on chronic stress. Hence the positive correlation found between stress, obesity and cardiovascular diseases. The chronic inflammatory state associated with insulin resistance and endothelial dysfunction is highly deleterious for vascular function. This review focuses on the proposed neuroimmunodulatory mechanisms linking chronic (psychological) stress, obesity and cardiovascular diseases.
C1 [Ippoliti, Flora; Canitano, Nicoletta] Univ Roma La Sapienza, Dept Expt Med, I-00161 Rome, Italy.
   [Businaro, Rita] Univ Roma La Sapienza, Dept Medicosurg Sci & Biotechnol, I-00161 Rome, Italy.
C3 Sapienza University Rome; Sapienza University Rome
RP Ippoliti, F (corresponding author), Univ Roma La Sapienza, Dept Expt Med, Viale Regina Elena 324, I-00161 Rome, Italy.
EM flora.ippoliti@uniroma1.it
RI Businaro, Rita/AAG-1866-2021
OI reverberi, massimo/0000-0003-3671-6783
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NR 162
TC 37
Z9 40
U1 0
U2 24
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1557-1890
EI 1557-1904
J9 J NEUROIMMUNE PHARM
JI J. Neuroimmune Pharm.
PD MAR
PY 2013
VL 8
IS 1
BP 212
EP 226
DI 10.1007/s11481-012-9432-6
PG 15
WC Neurosciences; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pharmacology & Pharmacy
GA 096YV
UT WOS:000315441900021
PM 23329173
OA Bronze
DA 2025-06-11
ER

PT J
AU Saiki, A
   Oyama, T
   Endo, K
   Ebisuno, M
   Ohira, M
   Koide, N
   Murano, T
   Miyashita, Y
   Shirai, K
AF Saiki, Atsuhito
   Oyama, Tomokazu
   Endo, Kei
   Ebisuno, Mariko
   Ohira, Masahiro
   Koide, Nobukiyo
   Murano, Takeyoshi
   Miyashita, Yoh
   Shirai, Kohji
TI Preheparin serum lipoprotein lipase mass might be a biomarker of
   metabolic syndrome
SO DIABETES RESEARCH AND CLINICAL PRACTICE
LA English
DT Article
DE preheparin lipoprotein lipase mass; urinary 8-OHdG; adiponectin;
   metabolic syndrome; oxidative stress
ID OXIDATIVE STRESS; DIABETES-MELLITUS; INSULIN-RESISTANCE; NAD(P)H
   OXIDASE; OBESITY; PLASMA; COMPLICATIONS; ADIPONECTIN; PROTEIN;
   ATHEROSCLEROSIS
AB Lipoprotein lipase mass in preheparin serum (preheparin LPL mass) is assumed to reflect some of the LPL production in the whole body and insulin sensitivity. While metabolic syndrome is a common underlying condition for cardiovascular diseases, biological marker of this syndrome has not been fully established. To clarify the characteristics of preheparin LPL mass in metabolic syndrome, 362 Japanese subjects were studied to examine the relationship between symptoms of metabolic syndrome and preheparin LPL mass and compare with plasma adiponectin. Furthermore the relation with urinary 8-hydroxydeoxyguanosine (8-OHdG) that reflects oxidative stress to DNA was also studied. Both preheparin LPL mass and plasma adiponectin correlated positively with HDL-cholesterol and negatively with body weight and triglyceride. Only preheparin LPL mass showed a negative correlation with fasting blood glucose and HbA1c. Both mean preheparin LPL mass and plasma adiponectin decreased with an increase in severity of the metabolic syndrome with/without obesity and with/without diabetes. The correlation coefficient between preheparin LPL mass and plasma adiponectin was r = 0.562. A negative correlation between preheparin LPL mass and urinary 8-OHdG was observed. These results suggest that low preheparin LPL mass may reflect systemic oxidative stress and also a biomarker of the severity of metabolic syndrome. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
C1 Toho Univ, Sakura Hosp, Sch Med, Ctr Diabet Endocrine & Metab, Sakura, Chiba 2858741, Japan.
   Toho Univ, Sakura Hosp, Sch Med, Dept Clin Lab, Chiba 2748510, Japan.
C3 Toho University; Toho University
RP Miyashita, Y (corresponding author), Toho Univ, Sakura Hosp, Sch Med, Ctr Diabet Endocrine & Metab, 564-1,Shimoshizu, Sakura, Chiba 2858741, Japan.
EM mumon@sf6.so-net.ne.jp
OI Ohira, Masahiro/0000-0002-1935-6125
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NR 40
TC 71
Z9 74
U1 0
U2 3
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0168-8227
EI 1872-8227
J9 DIABETES RES CLIN PR
JI Diabetes Res. Clin. Pract.
PD APR
PY 2007
VL 76
IS 1
BP 93
EP 101
DI 10.1016/j.diabres.2006.08.004
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 147GR
UT WOS:000244991900014
PM 16956692
DA 2025-06-11
ER

PT J
AU Chen, YH
   Chiou, HY
   Wang, HY
   Chung, KH
AF Chen, Yi-Hua
   Chiou, Hung-Yi
   Wang, Hsin-Yi
   Chung, Kuo-Hsuan
TI Sex differences in the associations between psychological symptoms and
   tumor necrosis factor-alpha levels among obese and nonobese children
   aged 6-13 in Taiwan
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Sex differences; Anxiety; Children; Adolescents; Tumor necrosis factor
   alpha(TNF-?); Obesity
ID CHILDHOOD OBESITY; TNF-ALPHA; GENDER-DIFFERENCES; METABOLIC SYNDROME;
   INFLAMMATION; MECHANISM; ANXIETY; STRESS; WOMEN
AB Background: Evidence of associations between psychological symptoms and tumor necrosis factor (TNF)-alpha level is scant, as is evidence on sex differences in associations for children and adolescents with obesity. This study examined sex differences in associations between psychological symptoms (self-concept, anxiety, depression, anger, and disruptive behavior) and TNF-alpha level in Taiwanese children and adolescents with healthy weight, overweight, or obesity.Methods: In 2010, 564 first, fourth, and seventh graders-comprising 250 children with overweight or obesity (44.3 %), 330 adolescents (58.5 %), and 303 males (53.7 %)-underwent a health examination and blood sampling and completed a questionnaire. Results: A significantly higher TNF-alpha level was found in children and adolescents with healthy weight than in those with overweight or obesity (median: 14.5 vs. 4.1 (pg/mL); p < 0.001). In multiple linear regression models, anxiety was significantly positively associated with TNF-alpha level in female participants with healthy weight (beta = 0.11 per 10 increments in anxiety, 95 % confidence interval = 0.01-0.22).Limitations: Given the cross-sectional nature of the study, no inferences of causal relationships among TNF-alpha level, obesity, and psychological symptoms could be made.Conclusions: The findings enrich the literature on the TNF-alpha-psychological symptom association. Sex differences were found in children and adolescents without obesity rather than in those without obesity, and a higher TNF-alpha level was associated with increased anxiety in girls without obesity. The role of sex differences in the complex associations among psychological symptoms, TNF-alpha level, and overweight or obesity requires further investigation.
C1 [Chen, Yi-Hua; Chiou, Hung-Yi; Wang, Hsin-Yi] Taipei Med Univ, Coll Publ Hlth, Sch Publ Hlth, Taipei, Taiwan.
   [Chen, Yi-Hua] Taipei Med Univ, Coll Publ Hlth, Res Ctr Hlth Equ, Taipei, Taiwan.
   [Chung, Kuo-Hsuan] Taipei Med Univ Hosp, Dept Psychiat, Taipei, Taiwan.
   [Chung, Kuo-Hsuan] Taipei Med Univ Hosp, Psychiat Res Ctr, Taipei, Taiwan.
   [Chung, Kuo-Hsuan] Taipei Med Univ, Coll Med, Sch Med, Dept Psychiat, Taipei, Taiwan.
   [Chung, Kuo-Hsuan] Taipei Med Univ Hosp, Dept Psychiat, 252 Wuxing St, Taipei 11031, Taiwan.
C3 Taipei Medical University; Taipei Medical University; Taipei Medical
   University Hospital; Taipei Medical University; Taipei Medical
   University; Taipei Medical University Hospital; Taipei Medical
   University; Taipei Medical University; Taipei Medical University
   Hospital
RP Chung, KH (corresponding author), Taipei Med Univ Hosp, Dept Psychiat, 252 Wuxing St, Taipei 11031, Taiwan.
EM ch2006ung@tmu.edu.tw
FU Taipei Medical University Hospital in Taipei, Taiwan; 
   [98TMU-TMUH-01-5];  [99TMU- TMUH-02-4]
FX This work was supported by Taipei Medical University Hospital in Taipei,
   Taiwan, under grant numbers 98TMU-TMUH-01-5 and 99TMU- TMUH-02-4.
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NR 37
TC 0
Z9 0
U1 0
U2 4
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD JAN 1
PY 2023
VL 320
BP 241
EP 246
DI 10.1016/j.jad.2022.09.073
EA OCT 2022
PG 6
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA 5K2UI
UT WOS:000869585500024
PM 36162686
DA 2025-06-11
ER

PT J
AU Akimov, OY
   Mykytenko, AO
   Kostenko, VO
   Yeroshenko, GA
AF Akimov, O. Y.
   Mykytenko, A. O.
   Kostenko, V. O.
   Yeroshenko, G. A.
TI INFLUENCE OF AMMONIUM PYRROLIDINEDITHIOCARBAMATE ADMINISTRATION ON THE
   DEVELOPMENT OF OXIDATIVE STRESS IN RAT HEART ON THE BACKGROUND OF
   METABOLIC SYNDROME MODELING
SO WORLD OF MEDICINE AND BIOLOGY
LA English
DT Article
DE metabolic syndrome; heart; NF-kappa B; ammonium
   pyrrolidinedithiocarbamate; oxidative stress
AB Metabolic syndrome, despite being a disease of non-infectious origin, is often accompanied by inflammation induced by metabolic disorders (meta-inflammation). The purpose of this work is to determine the activity of antioxidant enzymes, the production of superoxide anion radical, the content of oxidatively modified proteins and the concentration of malondialdehyde in the heart of rats under conditions of experimental metabolic syndrome and ammonium pyrrolidine dithiocarbamate administration. The study was conducted on 24 mature male Wistar rats weighing 200-260 g. The animals were divided into 4 groups of 6 animals each: control group; metabolic syndrome group (metabolic syndrome was reproduced by using a 20 % fructose solution as the only source of water for 60 days); ammonium pyrrolidinedithiocarbamate administration group (i.p. 76 mg/kg thrice a week for 60 days), and group of ammonium pyrrolidinedithiocarbamate administration on the background of metabolic syndrome modeling. Metabolic syndrome leads to development of oxidative stress in rat heart, which is characterized by excessive production of reactive oxygen species and insufficiency of antioxidant defense. Ammonium pyrrolidine dithiocarbamate administration decreased superoxide production by 55.44 %, increased superoxide dismutase and catalase activity by 156.32 % and 111.44 %, respectively, and decreased concentration of malondialdehyde by 22.41 %. Administration of blocker of NF-kappa B activation (ammonium pyrrolidinedithiocarbamate) during modeling of metabolic syndrome limits excessive production of reactive oxygen species and intensity of lipid peroxidation, while increasing antioxidant defense of rat heart.
C1 [Akimov, O. Y.; Mykytenko, A. O.; Kostenko, V. O.] Poltava State Med Univ, Poltava, Ukraine.
C3 Poltava State Medical University
RP Akimov, OY (corresponding author), Poltava State Med Univ, Poltava, Ukraine.
EM riseofrevan5@gmail.com
RI Yeroshenko, Galina/AAH-5312-2019; Akimov, Oleh/AAJ-7809-2021; Mykytenko,
   Andrii/HJZ-1628-2023
OI Galina, Yeroshenko/0000-0003-4279-485X
CR Aboonabi A, 2020, FREE RADICAL BIO MED, V150, P30, DOI 10.1016/j.freeradbiomed.2020.02.004
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NR 15
TC 0
Z9 0
U1 0
U2 0
PU SCIENTIFIC SOC ANATOMISTS HISTOLOGISTS & EMBRYOLOGISTS UKRAINE
PI POLTAVA
PA VUL SHEVCHENKA 23, POLTAVA, 36024, UKRAINE
SN 2079-8334
J9 WORLD MED BIOL
JI World Med. Biol.
PY 2024
VL 87
IS 1
BP 178
EP 182
DI 10.26724/2079-8334-2024-1-87-178-182
PG 5
WC Medicine, Research & Experimental
WE Emerging Sources Citation Index (ESCI)
SC Research & Experimental Medicine
GA UQ6P8
UT WOS:001249566400002
DA 2025-06-11
ER

PT J
AU Zhu, W
   Yang, F
   Cai, XF
   Zhang, W
   Zhang, JS
   Cai, M
   Li, XT
   Xiang, J
   Cai, DF
AF Zhu, Wen
   Yang, Feng
   Cai, Xiaofang
   Zhang, Wen
   Zhang, Jingsi
   Cai, Min
   Li, Xiangting
   Xiang, Jun
   Cai, Dingfang
TI Role of glucocorticoid receptor phosphorylation-mediated synaptic
   plasticity in anxiogenic and depressive behaviors induced by monosodium
   glutamate
SO NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
LA English
DT Article
DE Anxiety; Depression; Metabolic syndrome; Glucocorticoid receptor;
   Synaptic plasticity
ID TYPE-2 DIABETES-MELLITUS; PITUITARY-ADRENAL AXIS; INDUCED OBESE MICE;
   METABOLIC SYNDROME; NEUROTROPHIC FACTOR; DISORDER; ANXIETY;
   DYSREGULATION; ASSOCIATION; EXPRESSION
AB Psychiatric diseases and metabolic disorders frequently cooccur, yet the mechanisms underlying this interaction remain unknown. The aim of this study was to determine the role of glucocorticoid receptor (GR) phosphorylation in the comorbidity of metabolic and psychiatric disorders. Neonatal Sprague-Dawley rats were subcutaneously injected with monosodium glutamate (MSG) every 2 days for 10 days after birth. Metabolic and behavioral tests were performed 12 weeks later. Golgi staining and transmission electron microscopy (TEM) were performed to evaluate synaptic structural plasticity. Changes in GR phosphorylation and the BDNF/TrkB pathway were evaluated by western blotting and immunofluorescence. We found that MSG-treated rats displayed significant metabolic abnormalities accompanied by anxiogenic and depressive behaviors, an altered synaptic ultrastructure and the loss of dendritic spines. The expression of phosphorylated GR was reduced in the brain. Furthermore, a specific agonist of BDNF/TrkB significantly reversed the reduction in GR phosphorylation, as well as the metabolic and behavioral outcomes. These findings indicate that a decrease in BDNF/TrkB pathway-dependent GR phosphorylation is a long-term effect of MSG treatment that may contribute to metabolic and behavioral disturbances.
C1 [Zhu, Wen; Yang, Feng; Zhang, Wen; Zhang, Jingsi; Cai, Min; Li, Xiangting; Xiang, Jun; Cai, Dingfang] Fudan Univ, Zhongshan Hosp, Dept Integrat Med, Shanghai 200032, Peoples R China.
   [Zhu, Wen; Yang, Feng; Zhang, Wen; Zhang, Jingsi; Cai, Min; Li, Xiangting; Xiang, Jun; Cai, Dingfang] Fudan Univ, Inst Integrat Med, Lab Neurol, Shanghai 200032, Peoples R China.
   [Cai, Xiaofang] Fudan Univ, Zhongshan Hosp, Dept Stomatol, Shanghai 200032, Peoples R China.
C3 Fudan University; Fudan University; Fudan University
RP Xiang, J; Cai, DF (corresponding author), Fudan Univ, Zhongshan Hosp, Dept Integrat Med, Shanghai 200032, Peoples R China.; Xiang, J; Cai, DF (corresponding author), Fudan Univ, Inst Integrat Med, Lab Neurol, Shanghai 200032, Peoples R China.
EM xiang.jun@zs-hospital.sh.cn; cai.dingfang@zs-hospital.sh.cn
RI Yang, Tian/W-6668-2019
FU Development Project of Shanghai Peak Disciplines-Integrative Medicine
   [20180101]
FX This work was supported by the Development Project of Shanghai Peak
   Disciplines-Integrative Medicine (No. 20180101).
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NR 76
TC 10
Z9 10
U1 1
U2 8
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0028-1298
EI 1432-1912
J9 N-S ARCH PHARMACOL
JI Naunyn-Schmiedebergs Arch. Pharmacol.
PD JAN
PY 2021
VL 394
IS 1
BP 151
EP 164
DI 10.1007/s00210-020-01845-x
EA MAY 2020
PG 14
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA PN1PW
UT WOS:000534872100002
PM 32444989
DA 2025-06-11
ER

PT J
AU Luo, GS
   Li, YX
   Yao, C
   Li, MJ
   Li, J
   Zhang, XY
AF Luo, Guoshuai
   Li, Yaxi
   Yao, Cong
   Li, Meijuan
   Li, Jie
   Zhang, Xiangyang
TI Duration of untreated illness and clinical correlates in first-episode
   and drug-na?ve patients with major depressive disorder
SO PSYCHIATRY RESEARCH
LA English
DT Article
DE Major depressive disorder; Duration of untreated illness; Clinical
   correlates; First-episode; Drug-na?ve
ID METABOLIC SYNDROME; MENTAL-DISORDERS; SUICIDE ATTEMPTS; NAIVE PATIENTS;
   1ST ONSET; PSYCHOSIS; ANXIETY; SCHIZOPHRENIA; SYMPTOMS; DELAY
AB Backgrounds: The notion that a prolonged duration of untreated illness (DUI) leads to poorer outcomes has contributed to extensive changes in mental health services worldwide. However, most studies on DUI have focused on schizophrenia and related psychosis. This study aimed to assess the possible relationship between DUI and certain clinical correlates in first-episode and drug-naive patients with major depressive disorder (MDD).Methods: This cross-sectional study recruited 1718 first-episode and drug-naive MDD outpatients. All participants were scored on the Hamilton Depression Rating Scale, Hamilton Anxiety Rating Scale, Positive and Negative Syndrome Scale, and thyroid hormone and metabolic parameters were measured. We used the Structure Clinical Interview for DSM-IV for clinical diagnosis and investigated suicide attempts through face-to-face interviews.Results: A total of 171 (10%) of MDD patients had co-morbid psychiatric symptoms. Participants who were older, with lower education level, and married were less likely to seek a timely treatment compared to the counterparts. One-month longer untreated duration was associated with 2% to 9% higher odds of being with most of the investigated clinical conditions. For those with the longest DUI, the risk was increased for most of the investi-gated clinical conditions, with absolute risk differences ranging from 5.19% to 29.48%.Conclusions: These findings suggest that longer DUI may be negatively associated with clinical correlates in MDD. Further long-term follow-up studies are warranted to confirm these preliminary results.
C1 [Luo, Guoshuai; Yao, Cong; Li, Meijuan; Li, Jie] Tianjin Med Univ, Tianjin Anding Hosp, Inst Mental Hlth, Lab Biol Psychiat,Mental Hlth Ctr, 13 Liulin Rd, Tianjin 300222, Peoples R China.
   [Li, Yaxi] Shanghai Jiao Tong Univ, Shanghai Mental Hlth Ctr, Sch Med, 3210 Humin Rd, Shanghai 201108, Peoples R China.
   [Zhang, Xiangyang] Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, 16 Lincui Rd, Beijing 100101, Peoples R China.
C3 Tianjin Medical University; Shanghai Jiao Tong University; Chinese
   Academy of Sciences; Institute of Psychology, CAS
RP Li, J (corresponding author), Tianjin Med Univ, Tianjin Anding Hosp, Inst Mental Hlth, Lab Biol Psychiat,Mental Hlth Ctr, 13 Liulin Rd, Tianjin 300222, Peoples R China.; Zhang, XY (corresponding author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, 16 Lincui Rd, Beijing 100101, Peoples R China.
EM jieli@tmu.edu.cn; zhangxy@psych.ac.cn
RI Li, Jie/GNP-2561-2022; li, yue/IXD-9935-2023; Zhang,
   Xiangyang/ABC-7380-2022; Luo, Guoshuai/LEN-0867-2024
OI Luo, Guoshuai/0000-0002-0286-4369; Zhang, Xiangyang/0000-0003-3326-382X;
   Li, Yaxi/0000-0001-7616-5555
FU National Natural Science Foundation of China [81973759, 81573905];
   National Key R&D Program of China [2020YFC2003100, 2020YFC2003103];
   Capital's Funds for Health Improvement and Research [SF2020-1-2011]
FX This study was supported by the National Natural Science Foundation of
   China (81973759, 81573905) , the National Key R & D Program of China
   (2020YFC2003100, 2020YFC2003103) , the Capital's Funds for Health
   Improvement and Research (SF2020-1-2011) . This source had no further
   role in this study design, in the data collection and analysis, in the
   writing of the report, and in the decision to submit the paper for
   publication. The authors acknowledged the nurses and psychiatrists that
   provided professional support when conducting data collection.
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NR 51
TC 12
Z9 12
U1 0
U2 11
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0165-1781
EI 1872-7123
J9 PSYCHIAT RES
JI Psychiatry Res.
PD FEB
PY 2023
VL 320
AR 115056
DI 10.1016/j.psychres.2023.115056
EA JAN 2023
PG 8
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 8M5AF
UT WOS:000924476900001
PM 36680911
DA 2025-06-11
ER

PT J
AU Martocchia, A
   Gallucci, M
   Noale, M
   Maggi, S
   Cassol, M
   Stefanelli, M
   Postacchini, D
   Proietti, A
   Barbagallo, M
   Dominguez, LJ
   Ferri, C
   Desideri, G
   Toussan, L
   Pastore, F
   Falaschi, GM
   Paolisso, G
   Falaschi, P
AF Martocchia, Antonio
   Gallucci, Maurizio
   Noale, Marianna
   Maggi, Stefania
   Cassol, Maurizio
   Stefanelli, Manuela
   Postacchini, Demetrio
   Proietti, Antonella
   Barbagallo, Mario
   Dominguez, Ligia J.
   Ferri, Claudio
   Desideri, Giovambattista
   Toussan, Lavinia
   Pastore, Francesca
   Falaschi, Giulia M.
   Paolisso, Giuseppe
   Falaschi, Paolo
CA AGICO Investigators
TI The increased cortisol levels with preserved rhythmicity in aging and
   its relationship with dementia and metabolic syndrome
SO AGING CLINICAL AND EXPERIMENTAL RESEARCH
LA English
DT Article
DE Cortisol; Aging; Dementia; Metabolic syndrome
ID MINI-MENTAL-STATE; HIPPOCAMPAL ATROPHY; ALZHEIMERS-DISEASE; ALLOSTATIC
   LOAD; MEMORY; AGE; DEPRESSION; MACARTHUR; STRESS; MARKER
AB Background In the aging process, the cumulative exposure to stress with increased cortisol levels is considered to be associated to the senescence itself and its related disorders. Aims To evaluate the role of cortisol in elderly subjects, with or without dementia, by the means of the AGICO study. Methods The AGICO study enrolled patients from ten Geriatric Units in Italy in 2012-2017 (Study Director Prof Paolo Falaschi, S. Andrea Hospital of Rome). Every subject received a comprehensive geriatric assessment (including the Mini-Mental State Examination, MMSE), the neurological examination (with a computed tomography scan or magnetic resonance imaging of the brain), the assessment of the metabolic syndrome (MetS), the evaluation of the cortisol activity by two consecutive urine collections (diurnal and nocturnal). Results The MMSE was inversely related to the standardized diurnal and nocturnal urinary cortisol levels (p < 0.025 and p < 0.01, respectively) and the age was positively related (p < 0.01 and p < 0.001, respectively). The ratio between the standardized diurnal and nocturnal urinary cortisol levels was 1.50 +/- 1.2 (mean +/- standard deviation) and it was not modified by the age or dementia. The standardized diurnal and nocturnal urinary cortisol levels were significantly higher in patients with dementia (MMSE < 24) (p < 0.01). In the analysis of the subgroups with MetS, the highest concentrations of diurnal and nocturnal cortisol were found in patients with both dementia and MetS (p < 0.025 and p < 0.01, respectively). Discussion The AGICO study showed that the stress response significantly and progressively increases with age. Conclusion The cortisol increase in aging is related to the presence of both dementia and metabolic syndrome.
C1 [Martocchia, Antonio; Stefanelli, Manuela; Proietti, Antonella; Toussan, Lavinia; Falaschi, Giulia M.; Falaschi, Paolo] Sapienza Univ Rome, S Andrea Hosp, Via Grottarossa 1035, I-00189 Rome, Italy.
   [Gallucci, Maurizio] Local Hlth Author 2, Cognit Impairment Ctr, Treviso, Italy.
   [Noale, Marianna; Maggi, Stefania] Neurosci Inst, Natl Res Council, Padua, Italy.
   [Cassol, Maurizio] S Pietro Fatebenefratelli Hosp, Rome, Italy.
   [Postacchini, Demetrio] Italian Natl Res Ctr Aging IRCCS INRCA, Fermo, Italy.
   [Barbagallo, Mario; Dominguez, Ligia J.] Univ Palermo, Dept Internal Med & Geriatr, Palermo, Italy.
   [Ferri, Claudio; Desideri, Giovambattista] Univ Aquila, Laquila, Italy.
   [Paolisso, Giuseppe] Univ Campania L Vanvitelli, Dept Adv Med & Surg Sci, Naples, Italy.
C3 Sapienza University Rome; Azienda Ospedaliera Sant'Andrea; University of
   Palermo; University of L'Aquila; Universita della Campania Vanvitelli
RP Martocchia, A (corresponding author), Sapienza Univ Rome, S Andrea Hosp, Via Grottarossa 1035, I-00189 Rome, Italy.
EM antonio.martocchia@uniroma1.it
RI BARBAGALLO, MARIO/K-4794-2017; Martocchia, Antonio/GYU-9119-2022;
   Barbara, C./AAF-3397-2020; Noale, Marianna/IXD-2540-2023; Gallucci,
   Maurizio/K-1422-2018
OI Martocchia, Antonio/0000-0002-6201-5377; Gallucci,
   Maurizio/0000-0001-6329-3195
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NR 39
TC 4
Z9 4
U1 1
U2 6
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1594-0667
EI 1720-8319
J9 AGING CLIN EXP RES
JI Aging Clin. Exp. Res.
PD NOV
PY 2022
VL 34
IS 11
SI SI
BP 2733
EP 2740
DI 10.1007/s40520-022-02262-1
EA OCT 2022
PG 8
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA 6H4WI
UT WOS:000865200000001
PM 36190660
DA 2025-06-11
ER

PT J
AU Grattagliano, I
   Palmieri, VO
   Portincasa, P
   Moschetta, A
   Palasciano, G
AF Grattagliano, Ignazio
   Palmieri, Vincenzo O.
   Portincasa, Piero
   Moschetta, Antonio
   Palasciano, Giuseppe
TI Oxidative stress-induced risk factors associated with the metabolic
   syndrome: a unifying hypothesis
SO JOURNAL OF NUTRITIONAL BIOCHEMISTRY
LA English
DT Review
DE diabetes; endothelial dysfunction; HFE; hemochromatosis gene; insulin
   resistance; nonalcoholic fatty liver disease; reactive oxygen species;
   visceral obesity
ID FATTY LIVER-DISEASE; PROLIFERATOR-ACTIVATED RECEPTOR; NAD(P)H OXIDASE
   ACTIVITY; GLYCATION END-PRODUCTS; CORONARY-HEART-DISEASE;
   INSULIN-RESISTANCE; NONALCOHOLIC STEATOHEPATITIS; VITAMIN-E;
   NITRIC-OXIDE; CARDIOVASCULAR-DISEASE
AB Although the biochemical steps linking insulin resistance with the metabolic syndrome have not been completely clarified, mounting experimental and clinical evidence indicate oxidative stress as an attractive candidate for a central pathogenic role since it potentially explains the appearance of all risk factors and supports the clinical manifestations. In fact, metabolic syndrome patients exhibit activation of biochemical pathways leading to increased delivery of reactive oxygen species, decreased antioxidant protection and increased lipid peroxidation. The described associations between increased abdominal fat storage, liver steatosis and systemic oxidative stress, the diminished concentration of nitric oxide derivatives and antioxidant vitamins and the endothelial oxidative damages observed in subjects with the metabolic syndrome definitively support oxidative stress as the common second-level event in a unifying pathogenic view. Moreover, it has been observed that oxidative stress regulates the expression of genes governing lipid and glucose metabolism through activation or inhibition of intracellular sensors. Diet constituents can modulate redox reactions and the oxidative stress extent, thus also acting on nuclear gene expression. As a consequence of the food-gene interaction, metabolic syndrome patients may express different disease features and extents according to the different pathways activated by oxidative stress-modulated effectors. This view could also explain family differences and interethnic variations in determining risk factor appearance. This review mechanistically focused on oxidative stress events leading to individual disease factor appearance in metabolic syndrome patients and their setting for a more helpful clinical approach. (C) 2008 Elsevier Inc. All rights reserved.
C1 [Grattagliano, Ignazio; Palmieri, Vincenzo O.; Portincasa, Piero; Moschetta, Antonio; Palasciano, Giuseppe] Univ Bari, Sch Med, Dept Internal Med & Publ Med, Sect Internal Med, I-70124 Bari, Italy.
C3 Universita degli Studi di Bari Aldo Moro
RP Grattagliano, I (corresponding author), Univ Bari, Sch Med, Dept Internal Med & Publ Med, Sect Internal Med, I-70124 Bari, Italy.
EM i.grattagliano@semeiotica.uniba.it
RI portincasa, piero/J-7245-2018; Moschetta, Antonio/K-6211-2016
OI palmieri, vincenzo ostilio/0000-0002-7649-6028; portincasa,
   piero/0000-0001-5359-1471; Palasciano, Giuseppe/0000-0002-0396-488X;
   Moschetta, Antonio/0000-0003-2123-6074
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NR 159
TC 227
Z9 253
U1 0
U2 20
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0955-2863
EI 1873-4847
J9 J NUTR BIOCHEM
JI J. Nutr. Biochem.
PD AUG
PY 2008
VL 19
IS 8
BP 491
EP 504
DI 10.1016/j.jnutbio.2007.06.011
PG 14
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA 331IO
UT WOS:000258006100001
PM 17855068
OA Bronze
DA 2025-06-11
ER

PT J
AU Matthews, KA
   Jennings, JR
   Lee, L
   Pardini, D
AF Matthews, Karen A.
   Jennings, J. Richard
   Lee, Laisze
   Pardini, Dustin
TI Depressive Symptoms During Childhood and Cardiovascular Risk Factors in
   Black and White Men
SO PSYCHOSOMATIC MEDICINE
LA English
DT Article
DE cigarette smoking; depression; health behaviors; inflammation;
   longitudinal; men; metabolic syndrome; race
ID FLOW-MEDIATED VASODILATION; SHORT QUESTIONNAIRE; METABOLIC SYNDROME;
   MAJOR DEPRESSION; DISORDER; DISEASE; CALCIFICATION; PROGRESSION;
   ADULTHOOD; CHILDREN
AB Objective Depressive symptoms and major depression predict cardiovascular disease (CVD) and CVD risk factors in adulthood. Evidence regarding the role of depression in the development of CVD risk in youth is minimal. The study evaluated the prospective relationship of depressive symptoms in childhood and adolescence with adult CVD risk factors in black and white men.
   Methods Health behaviors and medical history were measured in 165 black and 146 white men (mean age = 32); a subset in the Pittsburgh area had a fasting blood draw to measure metabolic syndrome and inflammation. Adult CVD risk factors were related to depressive symptoms and childhood socioeconomic status (SES) prospectively measured annually from ages 7 to 16 years, followed by adjustments for adult SES and depressive symptoms.
   Results Men with higher depressive symptoms ages 7 to 16 smoked more cigarettes, B = 0.28 (standard error = 0.12), p = .015, and ate fewer servings of fruits and vegetables, B = -0.08 (0.04), p = .040, as adults. The association for smoking was independent of adult depressive symptoms (concurrent) and childhood and adult SES as well as race. Depressive symptoms during childhood were unrelated to the metabolic syndrome or biomarkers of inflammation in adulthood.
   Conclusions Depressive symptoms in childhood may predict later adverse health behaviors in black and white men. No evidence was found for an association between childhood depressive symptoms with metabolic syndrome or inflammation markers at ages approximately 32 years. The nature of the sample and lack of measurement of depressive disorder diagnosis tempers the conclusions, and future research is needed to determine associations with biological measures at later life span phases.
C1 [Matthews, Karen A.; Jennings, J. Richard; Lee, Laisze] Univ Pittsburgh, Dept Psychiat, 3811 Ohara St, Pittsburgh, PA 15213 USA.
   [Pardini, Dustin] Arizona State Univ, Dept Criminol & Criminal Justice, Tempe, AZ USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE); University
   of Pittsburgh; Arizona State University; Arizona State University-Tempe
RP Matthews, KA (corresponding author), Univ Pittsburgh, Dept Psychiat, 3811 Ohara St, Pittsburgh, PA 15213 USA.
EM matthewska@upmc.edu
RI Pardini, Dustin/E-3615-2013
FU National Heart, Lung, and Blood Institute at the National Institutes of
   Health [R01HL111802]; National Institute on Drug Abuse [DA411018];
   National Institute on Mental Health [MH48890, MH50778]; Pew Charitable
   Trusts; Office of Juvenile Justice and Delinquency Prevention
   [96-MU-FX-0012]
FX This research was supported by the National Heart, Lung, and Blood
   Institute at the National Institutes of Health (R01HL111802). Data
   collection for the Pittsburgh Youth Study has been funded by the
   National Institute on Drug Abuse (DA411018), National Institute on
   Mental Health (MH48890, MH50778), Pew Charitable Trusts, and the Office
   of Juvenile Justice and Delinquency Prevention (96-MU-FX-0012). The
   authors report no conflicts of interest.
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NR 28
TC 6
Z9 6
U1 0
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0033-3174
EI 1534-7796
J9 PSYCHOSOM MED
JI Psychosom. Med.
PD FEB-MAR
PY 2019
VL 81
IS 2
BP 176
EP 183
DI 10.1097/PSY.0000000000000652
PG 8
WC Psychiatry; Psychology; Psychology, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry; Psychology
GA HM6MS
UT WOS:000459591300008
PM 30422913
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Sagud, M
   Mihaljevic-Peles, A
   Uzun, S
   Cusa, BV
   Kozumplik, O
   Kudlek-Mikulic, S
   Mustapic, M
   Barisic, I
   Muck-Seler, D
   Pivac, N
AF Sagud, Marina
   Mihaljevic-Peles, Alma
   Uzun, Suzana
   Cusa, Bjanka Vuksan
   Kozumplik, Oliver
   Kudlek-Mikulic, Suzan
   Mustapic, Maja
   Barisic, Ivan
   Muck-Seler, Dorotea
   Pivac, Nela
TI The lack of association between components of metabolic syndrome and
   treatment resistance in depression
SO PSYCHOPHARMACOLOGY
LA English
DT Article
DE Major depressive disorder (MDD); Treatment-resistant depression (TRD);
   Metabolic syndrome (MetS); Components of the metabolic syndrome;
   Cardiovascular risk factors
ID CENTRAL SEROTONERGIC RESPONSIVITY; THERAPEUTIC RESPONSE; PAROXETINE;
   POPULATION
AB Although a number of studies investigated the link between major depressive disorder (MDD) and metabolic syndrome (MetS), the association between MetS and treatment-resistant depression (TRD) is still not clear.
   The aim of the study was to investigate the relationship between TRD and MetS and/or components of MetS and cardiovascular risk factors. Given the high prevalence of both conditions, the hypothesis was that TRD would be significantly associated with MetS.
   This cross-sectional study included 203 inpatients with MDD, assessed for the treatment resistance, MetS and its components, and severity of MDD. Diagnoses and evaluations were made with SCID based on DSM-IV, National Cholesterol Education Program Adult Treatment Panel III criteria, and the Hamilton Depression Rating Scale.
   TRD prior to study entry was found in 26.1 % of patients, while MetS was observed in 33.5 % of patients. The prevalence of MetS did not differ significantly between TRD and non-TRD patients. In addition, the frequency of the altered values of particular components of the MetS or cardiovascular risk factors was not associated with treatment resistance in depressed patients. Patients with TRD were older, had a higher number of lifetime episodes of depression and suicide attempts, and longer duration of MDD compared to non-TRD patients.
   The occurrence of either MetS or the particular components of the MetS and other cardiovascular risk factors was similar between TRD and non-TRD patients. Although there is a bidirectional relationship between depression and MetS, neither MetS nor its components appear to influence treatment resistance to antidepressants.
C1 [Sagud, Marina; Mihaljevic-Peles, Alma] Univ Zagreb, Sch Med, Zagreb 41001, Croatia.
   [Sagud, Marina; Mihaljevic-Peles, Alma] Clin Hosp Ctr Zagreb, Zagreb, Croatia.
   [Uzun, Suzana; Kozumplik, Oliver] Clin Psychiat Vrapce, Dept Gen Psychiat, Zagreb, Croatia.
   [Cusa, Bjanka Vuksan; Kudlek-Mikulic, Suzan] Clin Hosp Ctr Zagreb, Dept Psychiat, Zagreb, Croatia.
   [Mustapic, Maja; Muck-Seler, Dorotea; Pivac, Nela] Rudjer Boskovic Inst, Div Mol Med, HR-10002 Zagreb, Croatia.
   [Barisic, Ivan] Clin Hosp Ctr Zagreb, Dept Nephrol, Dialysis Unit, Zagreb, Croatia.
C3 University of Zagreb; University of Zagreb; UNIVERSITY ZAGREB HOSPITAL;
   University of Zagreb; UNIVERSITY ZAGREB HOSPITAL; Rudjer Boskovic
   Institute; University of Zagreb; UNIVERSITY ZAGREB HOSPITAL
RP Pivac, N (corresponding author), Rudjer Boskovic Inst, Div Mol Med, POB 180, HR-10002 Zagreb, Croatia.
EM npivac@irb.hr
RI Mustapic, Maja/AAV-3212-2020; Sagud, Marina/G-1265-2015
OI Pivac, Nela/0000-0003-3591-4868; Sagud, Marina/0000-0001-9620-2181;
   Mustapic, Maja/0000-0003-0511-2047
FU Croatian Ministry of Science, Education and Sport [098-0982522-2455,
   098-0982522-2457, 109-1083509-3513, 108-1083509-3511]
FX This study was supported by the Croatian Ministry of Science, Education
   and Sport, grants nos. 098-0982522-2455; 098-0982522-2457;
   109-1083509-3513; and 108-1083509-3511.
CR Amital D, 2008, J AFFECT DISORDERS, V110, P260, DOI 10.1016/j.jad.2008.01.006
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   Nemeroff CB, 2007, J CLIN PSYCHIAT, V68, P17
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NR 28
TC 28
Z9 34
U1 0
U2 7
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0033-3158
EI 1432-2072
J9 PSYCHOPHARMACOLOGY
JI Psychopharmacology
PD NOV
PY 2013
VL 230
IS 1
BP 15
EP 21
DI 10.1007/s00213-013-3085-x
PG 7
WC Neurosciences; Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA 235FA
UT WOS:000325700700003
PM 23579429
DA 2025-06-11
ER

PT J
AU Oliveira, PS
   Gazal, M
   Flores, NP
   Zimmer, AR
   Chaves, VC
   Reginatto, FH
   Kaster, MP
   Tavares, RG
   Spanevello, RM
   Lencina, CL
   Stefanello, FM
AF Oliveira, Pathise Souto
   Gazal, Marta
   Flores, Natlia Porto
   Zimmer, Aline Rigon
   Chaves, Vitor Clasen
   Reginatto, Flavio Henrique
   Kaster, Manuella Pinto
   Tavares, Rejane Giacomelli
   Spanevello, Roselia Maria
   Lencina, Claiton Leoneti
   Stefanello, Francieli Moro
TI Vaccinium virgatum fruit extract as an important adjuvant in
   biochemical and behavioral alterations observed in animal model of
   metabolic syndrome
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Article
DE Metabolic syndrome; Blueberry; Phenolic compounds; Metabolic parameters;
   Neurochemical parameters
ID CHRONIC MILD STRESS; OXIDATIVE STRESS; ANTIOXIDANT CAPACITY; BLUEBERRY
   EXTRACT; RAT MODEL; DEPRESSION; ANTHOCYANINS; OBESITY; DAMAGE;
   DYSLIPIDEMIA
AB The aim of this study was to investigate the effect of blueberry (Vaccinium virgatum) fruit extract on metabolic, behavioral and oxidative stress parameters in the hippocampus and cerebral cortex of mice submitted to an experimental model of metabolic syndrome induced by a highly palatable diet (HPD). Mice C57BL/6 were divided into 4 experimental groups: (1) received standard chow and saline orally, (2) received standard chow and blueberry hydroalcoholic extract, (3) received HPD and saline orally, (4) received HPD and blueberry hydroalcoholic extract. The animals were treated for 150 days. Our results showed that the animals fed with HPD presented insulin resistance, increased body weight, visceral fat, glucose, triglycerides, and total cholesterol when compared to the control group. The blueberry extract prevented the increase of these metabolic parameters. Also, the extract was able to reduce the levels of thiobarbituric acid reactive substances in the cerebral cortex and hippocampus of animals submitted to HPD. In contrast, no differences were observed in the total thiol content, activity of the antioxidant enzymes catalase and superoxide dismutase. In addition, the HPD fed animals showed a significant increase in immobility time in the forced swimming test and blueberry prevented this alteration, although no changes were observed in the ambulatory behavior, as well as in the anxiolytic profile of these animals. Overall, our findings suggest that chronic consumption of blueberry extract exhibits hypoglycemic, hypolipidemic, antidepressant-like and antiperoxidative effects in an animal model of metabolic syndrome. (C) 2017 Published by Elsevier Masson SAS.
C1 [Oliveira, Pathise Souto; Gazal, Marta; Flores, Natlia Porto; Tavares, Rejane Giacomelli; Lencina, Claiton Leoneti; Stefanello, Francieli Moro] Univ Fed Pelotas, Lab Biomarcadores, Ctr Ciencias Quim Farmaceut & Alimentos, Campus Univ S-N, Pelotas, RS, Brazil.
   [Zimmer, Aline Rigon] Univ Fed Rio Grande do Sul, Fac Farm, Porto Alegre, RS, Brazil.
   [Chaves, Vitor Clasen; Reginatto, Flavio Henrique] Univ Fed Santa Catarina, Ctr Ciencias Saude, Programa Posgrad Farm, Florianopolis, SC, Brazil.
   [Kaster, Manuella Pinto] Univ Fed Santa Catarina, Dept Bioquim, Campus Univ, BR-88040900 Florianopolis, SC, Brazil.
   [Spanevello, Roselia Maria] Univ Fed Pelotas, Lab Neuroquim Inflamacao & Canc, Ctr Ciencias Quim Farmaceut & Alimentos, Campus Univ S-N, Pelotas, RS, Brazil.
C3 Universidade Federal de Pelotas; Universidade Federal do Rio Grande do
   Sul; Universidade Federal de Santa Catarina (UFSC); Universidade Federal
   de Santa Catarina (UFSC); Universidade Federal de Pelotas
RP Stefanello, FM (corresponding author), Univ Fed Pelotas, Campus Univ S-N, BR-96160000 Pelotas, RS, Brazil.; Lencina, CL (corresponding author), Univ Fed Pelotas, Campus Univ Capao Leao, BR-96160000 Pelotas, RS, Brazil.
EM claiton.lencina@ufpel.edu.br; francieli.stefanelo@ufpel.edu.br
RI Zimmer, Aline/A-3330-2016; Spanevello, Roselia/H-1610-2018; Tavares,
   Rejane/C-1307-2010; Kaster, Manuella/D-5028-2013
OI REGINATTO, FLAVIO/0000-0002-4710-8540; Spanevello,
   Roselia/0000-0002-5117-2000; Kaster, Manuella/0000-0003-0258-6204;
   Giacomelli Tavares, Rejane/0000-0002-9806-1893
FU "Fundacao de Amparo a Pesquisa do Rio Grande do Sul" (FAPERGS);
   "Conselho Nacional de Desenvolvimento Cientifico e Tecnologico" (CNPq);
   "Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior" (CAPES)
FX This work was supported in part by grants from "Fundacao de Amparo a
   Pesquisa do Rio Grande do Sul" (FAPERGS), "Conselho Nacional de
   Desenvolvimento Cientifico e Tecnologico" (CNPq) and "Coordenacao de
   Aperfeicoamento de Pessoal de Nivel Superior" (CAPES). The authors also
   thank Hedy L. Hofmann for the corrections of the English version.
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NR 69
TC 18
Z9 19
U1 0
U2 12
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD APR
PY 2017
VL 88
BP 939
EP 947
DI 10.1016/j.biopha.2017.01.121
PG 9
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA EM7YJ
UT WOS:000395528000112
PM 28178625
DA 2025-06-11
ER

PT J
AU Dale, RM
   Bryant, KA
   Thompson, NR
AF Dale, Roman M.
   Bryant, Kelly A.
   Thompson, Nicolas R.
TI Metabolic Syndrome Rather Than Body Mass Index Is Associated With
   Treatment Response to Ketamine Infusions
SO JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
LA English
DT Article
DE ketamine; body mass index; metabolic syndrome; obesity
ID DEPRESSIVE SYMPTOMS; OBESITY; PREDICTORS; MECHANISMS; OVERWEIGHT; BMI
AB Purpose There is a practical need for the identification of pretreatment clinical and epidemiological response predictors to repeat ketamine infusions. Response predictors can serve to guide clinical inclusion of patients and weigh risks versus benefits for those receiving maintenance ketamine. Previous studies indicate a link between obesity, depression, and treatment response. We sought to investigate if body mass index (BMI) or metabolic syndrome could predict treatment response to ketamine. Methods Patients aged 18 to 72 years who were electroconvulsive therapy nonresponders were given a subanesthetic ketamine hydrochloride dose of 0.5 mg/kg delivered intravenously for 40 minutes for an acute series of 3 to 6 infusions every other day. If patients reported at least a 50% decrease in depression symptoms after the acute series, they were moved to a maintenance series of infusions, on an individualized basis. To assess if BMI or metabolic syndrome could predict response, logistic regression models were run to analyze initial responders, sustained responders, and nonresponders. Models were adjusted for age, sex, and baseline depression severity. Results Of the 150 patients analyzed, 56 did not respond to the acute phase, 38 initially responded to the acute phase but relapsed during the maintenance phase, and 56 sustained their response for 1 year. In unadjusted models, BMI was not shown to be a predictor of initial or sustained response. Alternatively, metabolic syndrome defined by a diagnosis of hypertension, hyperglycemia, or hyperlipidemia was determined to be significantly associated with diminished initial response but not sustained response. Conclusions In our patient group, results support the literature that outcome in antidepressant therapy is affected by the presence of metabolic syndrome rather than obesity itself. Although BMI did not predict initial response to ketamine, the presence of metabolic syndrome was significantly negatively associated with the initial response to an acute series of ketamine infusions.
C1 [Dale, Roman M.; Bryant, Kelly A.] Cleveland Clin, Lutheran Hosp, Ctr Behav Hlth, Cleveland, OH 44106 USA.
   [Thompson, Nicolas R.] Quantitat Hlth Sci, Cleveland, OH USA.
C3 Cleveland Clinic Foundation
RP Bryant, KA (corresponding author), Lutheran Hosp, 1730 W 25th St,Desk 5E, Cleveland, OH 44113 USA.
EM anglek@ccf.org
OI Bryant, Kelly/0000-0001-5002-9811
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NR 39
TC 20
Z9 20
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0271-0749
EI 1533-712X
J9 J CLIN PSYCHOPHARM
JI J. Clin. Psychopharmacol.
PD JAN-FEB
PY 2020
VL 40
IS 1
BP 75
EP 79
DI 10.1097/JCP.0000000000001149
PG 5
WC Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Pharmacology & Pharmacy; Psychiatry
GA KB3HM
UT WOS:000506390600011
PM 31834094
DA 2025-06-11
ER

PT J
AU Kliewer, W
   Robins, JL
AF Kliewer, Wendy
   Robins, Jo Lynne
TI Adverse Childhood Experiences Are Associated with Cardiometabolic Risk
   Indicators and Telomere Length in Low-Income African-American
   Adolescents
SO INTERNATIONAL JOURNAL OF BEHAVIORAL MEDICINE
LA English
DT Article
DE Adverse childhood experiences; Telomeres; Adolescents; African-American;
   Cardiometabolic risk; Waist circumference; Inflammation
ID C-REACTIVE PROTEIN; CARDIOVASCULAR RISK; INSULIN-RESISTANCE; CHILDREN;
   OBESITY; STRESS
AB Background Adverse childhood experiences (ACEs) have been linked to increased risk for cardiovascular disease later in life, and to shortened telomere length in children and adolescents, but few studies have examined associations between ACEs and cardiometabolic risk in adolescence or potential associations between ACEs, cardiometabolic risk indicators, and telomere length in this population. The present study examined competing models of associations between adolescent ACEs (as reported by mothers); cardiovascular, inflammatory, and metabolic indicators of health risk; and leukocyte telomere length in youth. Method Data was collected from 108 low-income African-American adolescents (42.6% male; M-age = 14.27 years, SD = 1.17) living in the southeastern USA. Waist circumference was measured during a home interview, and measures of C-reactive protein, insulin resistance, and leukocyte telomere length were obtained from blood following overnight fasting. Results Path analysis supported a main effects model, whereby ACEs were significantly associated with shortened leukocyte telomere length, higher levels of C-reactive protein, and larger waist circumferences, controlling for maternal education and adolescent sex. Exploratory analyses examining whether cardiometabolic risk mediated associations between ACEs and telomere length, or whether telomere length mediated associations between ACEs and cardiometabolic risk, were not supported. Conclusions ACEs are associated with risk of future cardiometabolic disorders and shortened leukocyte telomere length. Because cytogenetic changes are potentially modifiable, interventions to decrease family ACEs or alter responses to ACEs may lessen chronic disease risk in the African-American population. Targeted interventions to improve health are discussed.
C1 [Kliewer, Wendy] Virginia Commonwealth Univ, Dept Psychol, Box 842018, Richmond, VA 23284 USA.
   [Robins, Jo Lynne] Virginia Commonwealth Univ, Sch Nursing, Dept Family & Community Hlth, Box 980567, Richmond, VA 23298 USA.
C3 Virginia Commonwealth University; Virginia Commonwealth University
RP Kliewer, W (corresponding author), Virginia Commonwealth Univ, Dept Psychol, Box 842018, Richmond, VA 23284 USA.
EM wkliewer@vcu.edu; jwrobins@vcu.edu
OI Kliewer, Wendy/0000-0003-0046-203X; Robins, Jo Lynne
   W/0000-0003-3233-2897
FU Virginia Commonwealth University Presidential Research Quest Fund
FX The authors received funding for this study from the Virginia
   Commonwealth University Presidential Research Quest Fund.
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NR 29
TC 8
Z9 9
U1 1
U2 6
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1070-5503
EI 1532-7558
J9 INT J BEHAV MED
JI Int. J. Behav. Med.
PD FEB
PY 2022
VL 29
IS 1
BP 131
EP 135
DI 10.1007/s12529-021-09978-w
EA APR 2021
PG 5
WC Psychology, Clinical
WE Social Science Citation Index (SSCI)
SC Psychology
GA YI6BC
UT WOS:000636910300001
PM 33821432
OA Bronze
DA 2025-06-11
ER

PT J
AU Klisic, A
   Kavaric, N
   Vujcic, S
   Spasojevic-Kalimanovska, V
   Kotur-Stevuljevic, J
   Ninic, A
AF Klisic, Aleksandra
   Kavaric, Nebojsa
   Vujcic, Sanja
   Spasojevic-Kalimanovska, Vesna
   Kotur-Stevuljevic, Jelena
   Ninic, Ana
TI Factorial Analysis of the Cardiometabolic Risk Influence on Redox Status
   Components in Adult Population
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Article
ID OXIDATIVE STRESS; THIOL/DISULPHIDE HOMEOSTASIS; LIPID-ACCUMULATION;
   OBESITY; ENDOCAN; INDEX; ASSAY
AB Different byproducts of oxidative stress do not always lead to the same conclusion regarding its relationship with cardiometabolic risk, since controversial results are reported so far. The aim of the current study was to examine prooxidant determinant ((prooxidant-antioxidant balance (PAB)) and the marker of antioxidant defence capacity (total sulphydryl groups (tSHG)), as well as their ratio (PAB/tSHG) in relation to different cardiometabolic risk factors in the cohort of adult population. Additionally, we aimed to examine the joint effect of various cardiometabolic parameters on these markers, since to our knowledge, there are no studies that investigated that issue. A total of 292 participants underwent anthropometric measurements and venipuncture procedure for cardiometabolic risk factors assessment. Waist-to-height ratio (WHtR), body mass index, visceral adiposity index (VAI), and lipid accumulation product (LAP) were calculated. Principal component analysis (PCA) grouped various cardiometabolic risk parameters into different factors. This analysis was used in the subsequent binary logistic regression analysis to estimate the predictive potency of the factors towards the highest PAB and tSHG values. Our results show that triglycerides, VAI, and LAP were positively and high density lipoprotein cholesterol (HDL-c) were negatively correlated with tSHG levels and vice versa with PAB/tSHG index, respectively. On the contrary, there were no independent correlations between each cardiometabolic risk factor and PAB. PCA revealed that obesity-renal function-related factor (i.e., higher WHtR, but lower urea and creatinine) predicts both high PAB (OR=1.617, 95% CI (1.204-2.171), P<0.01) and low tSHG values (OR=0.443, 95% CI (0.317-0.618), P<0.001), while obesity-dyslipidemia-related factor (i.e., lower HDL-c and higher triglycerides, VAI, and LAP) predicts high tSHG values (OR=2.433, 95% CI (1.660-3.566), P<0.001). In conclusion, unfavorable cardiometabolic profile was associated with higher tSHG values. Further studies are needed to examine whether increased antioxidative capacity might be regarded as a compensatory mechanism due to free radicals' harmful effects.
C1 [Klisic, Aleksandra; Kavaric, Nebojsa] Univ Montenegro, Primary Hlth Care Ctr, Fac Med, Podgorica, Montenegro.
   [Vujcic, Sanja; Spasojevic-Kalimanovska, Vesna; Kotur-Stevuljevic, Jelena; Ninic, Ana] Univ Belgrade, Dept Med Biochem, Fac Pharm, Belgrade, Serbia.
C3 University of Montenegro; University of Belgrade
RP Klisic, A (corresponding author), Univ Montenegro, Primary Hlth Care Ctr, Fac Med, Podgorica, Montenegro.
EM aleksandranklisic@gmail.com
RI Klisic, Aleksandra/ABC-9219-2020
OI Vujcic, Sanja/0000-0002-5557-1850; Ninic, Ana/0000-0003-3838-1606
FU Ministry of Science, Montenegro; Ministry of Education, Science and
   Technological Development, Republic of Serbia [451-03-68/2020-14/200161]
FX This work was financially supported in part by a grant from the Ministry
   of Science, Montenegro and the Ministry of Education, Science and
   Technological Development, Republic of Serbia (project number
   451-03-68/2020-14/200161).
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NR 36
TC 19
Z9 19
U1 0
U2 11
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PD APR 15
PY 2021
VL 2021
DI 10.1155/2021/6661940
PG 9
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA UJ0KN
UT WOS:000690984200004
PM 33936384
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Yamaguchi, Y
   Yoshikawa, N
   Nagae, M
   Kagota, S
   Haginaka, J
   Nakamura, K
   Kunitomo, M
AF Yamaguchi, Yu
   Yoshikawa, Noriko
   Nagae, Mariko
   Kagota, Satomi
   Haginaka, Jun
   Nakamura, Kazuki
   Kunitomo, Masaru
TI Increased systemic oxidative and nitrative stress in a new congenic
   model of metabolic syndrome derived from stroke-prone spontaneously
   hypertensive rats and zucker fatty rats
SO CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
LA English
DT Article; Proceedings Paper
CT 2nd International Symposium on Lifestyle-Related Disease - Perspective
   for Primary Prevention and Treatment in Animal Models and Humans
CY OCT 21-22, 2006
CL Nishinomiya, JAPAN
SP Minist Educ, Culture, Sports, Sci & Technol
DE animal model; inflammation; metabolic syndrome; nitrative stress;
   oxidative stress
ID PEROXYNITRITE; LIPOPROTEIN
AB 1. Oxidative stress has been recognized as an important factor in the biology of lifestyle-related diseases. Systemic oxidative stress may increase in metabolic syndrome characterized by a cluster of metabolic risk factors. To confirm this hypothesis, we investigated systemic oxidative/nitrative stress in a new congenic model of metabolic syndrome, namely SHRSP/ZF rats, which are derived from stroke-prone spontaneously hypertensive (SHRSP) and Zucker fatty (Zucker) rats.
   2. The SHRSP/ZF rats display obesity, hypertension, hyperlipidaemia, hyperglycaemia and glucose intolerance. At 6 weeks of age, SHRSP/ZF rats already showed increases in serum levels of thiobarbituric acid-reactive substances (TBARS) and oxidatively modified low-density lipoprotein (Ox-LDL) compared with lean SHRSP littermates and Zucker rats, whereas serum levels of 8-hydroxy-2'-deoxyguanine (8-OHdG), 3-nitrotyrosine, 3-chlorotyrosine and high-sensitivity C-reactive protein (hsCRP), an inflammatory marker, did not differ significantly among the three rat strains. However, levels of these oxidative/nirative stress markers in SHRSP/ZF rats, as well as in SHRSP, increased gradually with age. After 36 weeks of age, the levels of TBARS, 8-OHdG, 3-nitrotyrosine and hsCRP in SHRSP/ZF rats increased rapidly and three of six rats died thereafter. Increased oxidative/nitrative stress may be associated with death in these rats.
   3. Our findings indicate that systemic oxidative/nitrative stress is evidently increased in metabolic syndrome.
C1 Mukogawa Womens Univ, Sch Pharm & Pharmaceut Sci, Dept Pharmacol, Nishinomiya, Hyogo 6638179, Japan.
   Mukogawa Womens Univ, Sch Pharm & Pharmaceut Sci, Dept Analyt Chem, Nishinomiya, Hyogo 6638179, Japan.
C3 Mukogawa Women's University; Mukogawa Women's University
RP Yamaguchi, Y (corresponding author), Mukogawa Womens Univ, Sch Pharm & Pharmaceut Sci, Dept Pharmacol, 11-68 Koshien Kyuban Cho, Nishinomiya, Hyogo 6638179, Japan.
EM yusan@mukogawa-u.ac.jp
RI Haginaka, Jun/K-5672-2012
OI Haginaka, Jun/0000-0001-6760-7745
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   Yamaguchi Y, 2006, NITRIC OXIDE-BIOL CH, V15, P380, DOI 10.1016/j.niox.2006.04.264
NR 7
TC 2
Z9 2
U1 2
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1440-1681
J9 CLIN EXP PHARMACOL P
JI Clin. Exp. Pharmacol. Physiol.
PD NOV
PY 2007
VL 34
SU 1
BP S26
EP S28
DI 10.1111/j.1440-1681.2007.04766.x
PG 3
WC Pharmacology & Pharmacy; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Pharmacology & Pharmacy; Physiology
GA 229CZ
UT WOS:000250780400010
DA 2025-06-11
ER

PT J
AU Madan, S
   Sembhi, J
   Khurana, N
   Makkar, K
   Byati, P
AF Madan, Shobhit
   Sembhi, Jasraj
   Khurana, Navpreet
   Makkar, Kanika
   Byati, Priya
TI Yoga for Preventive Health: A Holistic Approach
SO AMERICAN JOURNAL OF LIFESTYLE MEDICINE
LA English
DT Article
DE yoga; preventative health; holistic health; meditation; inflammation;
   optimal health; mental health; neurohormones; exercise
ID MEDITATION
AB Yoga has been prevalent for over 5000 years; it originated in India and has become an essential lifestyle ingredient for achieving optimal health. The goal of this article in lifestyle modification is to increase awareness about the benefits of yoga and how its practice can reduce the overall risk of chronic diseases. Yoga has been proven to be therapeutic for enhancing immunity and support management of chronic diseases such as cardiovascular, respiratory, endocrine disorders, obesity, cancer, and metabolic syndrome. Yoga techniques called asanas, such as pranayama for breathing regulation and dhyana for meditation, boost innate immune response, interrupt inflammation, and thereby prevent the manifestation of chronic diseases. Yoga also provides symptomatic relief for chronic arthritis by increasing joint flexibility and microcirculation. Yoga and meditation regulate neurotransmitters, neuropeptides, hormones, and cytokines that mediate interactions between the central nervous system and the immune system. These techniques reduce the psychological and physiological effects of chronic stress. Serotonin, oxytocin, and melatonin released directly due to practicing yoga have been shown to better manage anxiety and fear, especially during the pandemic. We believe the current trends of chronic disease management will become more effective with the implementation of lifestyle changes using yoga.
C1 [Madan, Shobhit] Univ Pittsburgh, Grad Sch Publ Hlth, Epidemiol, 261 Corey Dr, Pittsburgh, PA 15044 USA.
   Drexel Univ, Philadelphia, PA 19104 USA.
   Indira Gandhi Govt Med Coll & Hosp, Nagpur, Maharashtra, India.
   Pandit Bhagwat Dayal Sharma Post Grad Inst Med Sc, Pathol, Rohtak, Haryana, India.
   George Washington Univ, Sch Publ Hlth & Hlth Serv, Washington, DC USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE); University
   of Pittsburgh; Drexel University; Pt. B.D. Sharma Post Graduate
   Institute of Medical Sciences (PGIMS), Rohtak; George Washington
   University
RP Madan, S (corresponding author), Univ Pittsburgh, Grad Sch Publ Hlth, Epidemiol, 261 Corey Dr, Pittsburgh, PA 15044 USA.
EM shobhitmadan@gmail.com
OI Madan, Shobhit/0000-0001-9222-1588
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NR 29
TC 5
Z9 5
U1 2
U2 15
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1559-8276
EI 1559-8284
J9 AM J LIFESTYLE MED
JI Am. J. Lifestyle Med.
PD MAY
PY 2023
VL 17
IS 3
SI SI
BP 418
EP 423
DI 10.1177/15598276211059758
EA JAN 2022
PG 6
WC Public, Environmental & Occupational Health
WE Emerging Sources Citation Index (ESCI)
SC Public, Environmental & Occupational Health
GA F4RC3
UT WOS:000740969900001
PM 37304753
OA Green Published
DA 2025-06-11
ER

PT J
AU Nathan, PJ
   O'Neill, BV
   Napolitano, A
   Bullmore, ET
AF Nathan, Pradeep J.
   O'Neill, Barry V.
   Napolitano, Antonella
   Bullmore, Edward T.
TI Neuropsychiatric Adverse Effects of Centrally Acting Antiobesity Drugs
SO CNS NEUROSCIENCE & THERAPEUTICS
LA English
DT Review
DE Adverse events; Antiobesity; Antiobesity drugs; Anxiety; Bupropion;
   Cannabinoid receptor; CB1 receptor; Central; Contrave; Depression;
   Drugs; Ecopipam; Lorcaserin; mu-opioid receptor; Naltrexone; Obesity;
   Psychiatric; Psychological; Rimonabant; Sedation; Sibutramine; Side
   effects; Sleep; Taranabant; Tesofensine; Topiramate; Treatments;
   Zonisamide
ID RANDOMIZED CONTROLLED-TRIAL; PLACEBO-CONTROLLED TRIAL; BINGE-EATING
   DISORDER; CB1 CANNABINOID RECEPTORS; CARDIOMETABOLIC RISK-FACTORS;
   TYPE-2 DIABETIC-PATIENTS; WEIGHT-LOSS; DOUBLE-BLIND; NALTREXONE
   TREATMENT; ENERGY-BALANCE
AB Introduction: Central neurochemical systems including the monoamine, opioid, and cannabinoid systems have been promising targets for antiobesity drugs that modify behavioral components of obesity. In addition to modulating eating behavior, centrally acting antiobesity drugs are also likely to alter emotional behavior and cognitive function due to the high expression of receptors for the neurochemical systems targeted by these drugs within the frontostriatal and limbic circuitry. Methods: This paper reviewed the neuropsychiatric adverse effects of past and current antiobesity drugs, with a central mechanism of action, linking the adverse effects to their underlying neural substrates and neurochemistry. Results: Antiobesity drugs were found to have varying neuropsychiatric adverse event profiles. Insomnia was the most common adverse effect with drugs targeting monoamine systems (sibutramine, bupropion and tesofensine). These drugs had some positive effects on mood and anxiety and may have added therapeutic benefits in obese patients with comorbid depression and anxiety symptoms. Sedation and tiredness were the most common adverse effects reported with drugs targeting the m-opioid receptors (i.e., naltrexone) and combination therapies targeting the opioid and monoamine systems (i.e., Contrave (TM)). Cognitive impairments were most frequently associated with the antiepileptic drugs, topiramate and zonisamide, consistent with their sedative properties. Drugs targeting the cannabinoid system (rimonabant and taranabant) were consistently associated with symptoms of anxiety and depression, including reports of suicidal ideation. Similar adverse events have also been noted for the D-1/D-5 antagonist ecopipam. Conclusion: These findings highlight the need to assess neuropsychiatric adverse events comprehensively using sensitive and validated methods early in the clinical development of candidate antiobesity drugs with a central mechanism of action.
C1 [Nathan, Pradeep J.] GlaxoSmithKline, Expt Med, Clin Unit Cambridge, Cambridge CB2 2GG, England.
   [Nathan, Pradeep J.; O'Neill, Barry V.; Bullmore, Edward T.] Univ Cambridge, Brain Mapping Unit, Dept Psychiat, Cambridge CB2 1TN, England.
   [Nathan, Pradeep J.] Monash Univ, Sch Psychol & Psychiat, Clayton, Vic 3800, Australia.
   [Napolitano, Antonella] Inst Metab Sci, WDEC, Cambridge, England.
C3 GlaxoSmithKline; Glaxosmithkline United Kingdom; University of
   Cambridge; Monash University; University of Cambridge
RP Nathan, PJ (corresponding author), GlaxoSmithKline, Expt Med, Clin Unit Cambridge, Addenbrookes Hosp Hills Rd, Cambridge CB2 2GG, England.
EM pn254@cam.ac.uk
RI Napolitano, Antonio/AAA-7596-2020; Bullmore, Ed/C-1706-2012
OI Bullmore, Edward/0000-0002-8955-8283
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NR 157
TC 76
Z9 82
U1 0
U2 28
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1755-5930
EI 1755-5949
J9 CNS NEUROSCI THER
JI CNS Neurosci. Ther.
PY 2011
VL 17
IS 5
BP 490
EP 505
DI 10.1111/j.1755-5949.2010.00172.x
PG 16
WC Neurosciences; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pharmacology & Pharmacy
GA 824CM
UT WOS:000295178700019
PM 21951371
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Rethorst, CD
   Leonard, D
   Barlow, CE
   Willis, BL
   Trivedi, MH
   DeFina, LF
AF Rethorst, C. D.
   Leonard, D.
   Barlow, C. E.
   Willis, B. L.
   Trivedi, M. H.
   DeFina, L. F.
TI Effects of depression, metabolic syndrome, and cardiorespiratory fitness
   on mortality: results from the Cooper Center Longitudinal Study
SO PSYCHOLOGICAL MEDICINE
LA English
DT Article
DE Cardiorespiratory fitness; physical activity; depression; metabolic
   syndrome; mortality
ID ALL-CAUSE MORTALITY; CARDIOVASCULAR-DISEASE MORTALITY; NUTRITION
   EXAMINATION SURVEY; 3RD NATIONAL-HEALTH; PHYSICAL-ACTIVITY; RISK-FACTOR;
   MEN; PREDICTORS; INACTIVITY; BURDEN
AB Background. Depression and metabolic syndrome (MetS) are frequently comorbid disorders that are independently associated with premature mortality. Conversely, cardiorespiratory fitness (CRF) is associated with reduced mortality risk. These factors may interact to impact mortality; however, their effects have not been assessed concurrently. This analysis assessed the mortality risk of comorbid depression/MetS and the effect of CRF on mortality in those with depression/MetS.
   Methods. Prospective study of 47 702 adults in the Cooper Center Longitudinal Study. Mortality status was attained from the National Death Index. History of depression was determined by patient response (yes or no) to a standardized medical history questionnaire. MetS was categorized using the American Heart Association/National Heart, Lung, and Blood Institute criteria. CRF was estimated from the final speed/grade of a treadmill graded exercise test.
   Results. 13.9% reported a history of depression, 21.4% met criteria for MetS, and 3.0% met criteria for both MetS and history of depression. History of depression (HR = 1.24, p = 0.003) and MetS (HR = 1.28, p < 0.001) were independently associated with an increased mortality risk, with the greatest mortality risk among individuals with both a history of depression and MetS (HR = 1.59, p < 0.001). Higher CRF was associated with a significantly lower risk of mortality (p < 0.001) in all individuals, including those with MetS and/or a history of depression.
   Conclusions. Those with higher levels CRF had reduced mortality risk in the context of depression/MetS. Interventions that improve CRF could have substantial impact on the health of persons with depression/MetS.
C1 [Rethorst, C. D.; Trivedi, M. H.] Univ Texas Southwestern Med Ctr Dallas, Dept Psychiat, Ctr Depress Res & Clin Care, Dallas, TX USA.
   [Leonard, D.; Barlow, C. E.; Willis, B. L.; DeFina, L. F.] Cooper Inst, Dallas, TX USA.
C3 University of Texas System; University of Texas Southwestern Medical
   Center Dallas; Cooper Institute
RP Rethorst, CD (corresponding author), Univ Texas Southwestern Med Ctr Dallas, Dept Psychiat, Ctr Depress Res & Clin Care, Dallas, TX USA.
EM chad.rethorst@utsouthwestern.edu
RI Rethorst, Chad/IXX-0200-2023; wright, beth/V-7496-2019; Trivedi,
   Madhukar/A-9029-2013
OI Trivedi, Madhukar/0000-0002-2983-1110; Rethorst,
   Chad/0000-0002-8168-2829
FU NIMH [K01MH097847]
FX We would like to thank A. John Rush for his thoughtful review and
   critique of the manuscript. In addition, we thank Dr Kenneth H. Cooper
   of the Cooper Clinic for establishing the CCLS, the Cooper Clinic
   physicians and technicians for data collection, and The Cooper Institute
   staff for data management. No funding sources were involved in the
   design or conduct of the study. Chad D. Rethorst is supported by NIMH
   K01MH097847. NIMH had no role in the analysis and interpretation of the
   data; or preparation review, or approval of the manuscript; or the
   decision to submit the manuscript for publication.
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NR 33
TC 15
Z9 15
U1 0
U2 19
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
SN 0033-2917
EI 1469-8978
J9 PSYCHOL MED
JI Psychol. Med.
PD OCT
PY 2017
VL 47
IS 14
BP 2414
EP 2420
DI 10.1017/S0033291717000897
PG 7
WC Psychology, Clinical; Psychiatry; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA FG7ZF
UT WOS:000410643500003
PM 28414015
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Kato, T
   Ogasawara, K
   Motomura, K
   Kato, M
   Tanaka, T
   Takaesu, Y
   Nio, S
   Kishi, T
   So, MR
   Nemoto, K
   Suzuki, E
   Watanabe, K
   Matsuo, K
AF Kato, Tadafumi
   Ogasawara, Kazuyoshi
   Motomura, Keisuke
   Kato, Masaki
   Tanaka, Teruaki
   Takaesu, Yoshikazu
   Nio, Shintaro
   Kishi, Taro
   So, Mirai
   Nemoto, Kiyotaka
   Suzuki, Eiji
   Watanabe, Koichiro
   Matsuo, Koji
CA JSMD Bipolar Disorder Guidelines Revision Working Grp
   JSMD Bipolar Disorder Comm
   JSMD Gidelines Comm
TI Practice Guidelines for Bipolar Disorder by the JSMD (Japanese Society
   of Mood Disorders)
SO PSYCHIATRY AND CLINICAL NEUROSCIENCES
LA English
DT Review
DE bipolar disorder; meta-analysis; pharmacotherapy; psychosocial support;
   systematic review
ID CLINICAL-PRACTICE GUIDELINES; NEW-ZEALAND COLLEGE;
   MENTAL-HEALTH-SERVICES; TASK-FORCE REPORT; METABOLIC SYNDROME;
   INTERNATIONAL SOCIETY; CONTROLLED-TRIAL; DECISION-MAKING; SINGLE-BLIND;
   DEPRESSION
AB The Japanese Society of Mood Disorders (JSMD) published treatment guidelines of bipolar disorder in 2011. The present guidelines incorporating new findings were developed to comply to the guidelines of the National Academy of Medicine (NAM) by utilizing systematic reviews and meta-analysis and taking patient and family opinions as well as insights from multiple professional fields into account. They support combination therapy using mood stabilizers and second-generation antipsychotics in many aspects. They also have limitations, including the grouping of mood stabilizers and second-generation antipsychotics when meta-analysis was performed despite their distinct properties, due to the scarcity of drug-specific evidence. Despite the limitations, these guidelines provide clinical decision support for psychiatrists in Japan.
C1 [Kato, Tadafumi] Juntendo Univ, Grad Sch Med, Dept Psychiat & Behav Sci, Tokyo, Japan.
   [Ogasawara, Kazuyoshi] Nagoya Univ Hosp, Ctr Postgrad Clin Training & Career Dev, Nagoya, Japan.
   [Motomura, Keisuke] NHO Hizen Psychiat Med Ctr, Clin Res Div, Yoshinogari, Japan.
   [Kato, Masaki] Kansai Med Univ, Dept Neuropsychiat, Hirakata, Japan.
   [Tanaka, Teruaki] KKR Sapporo Med Ctr, Dept Psychiat, Sapporo, Japan.
   [Takaesu, Yoshikazu] Univ Ryukyus, Grad Sch Med, Dept Neuropsychiat, Nishihara, Japan.
   [Nio, Shintaro] Saiseikai Cent Hosp, Dept Psychiat, Tokyo, Japan.
   [Kishi, Taro] Fujita Hlth Univ, Sch Med, Dept Psychiat, Toyoake, Japan.
   [So, Mirai] Tokyo Dent Coll, Dept Psychiat, Tokyo, Japan.
   [Nemoto, Kiyotaka] Univ Tsukuba, Inst Med, Dept Psychiat, Tsukuba, Japan.
   [Suzuki, Eiji] Tohoku Med & Pharmaceut Univ, Div Psychiat, Sendai, Japan.
   [Watanabe, Koichiro] Kyorin Univ, Fac Med, Dept Neuropsychiat, Mitaka, Japan.
   [Matsuo, Koji] Saitama Med Univ, Fac Med, Dept Psychiat, Moroyama, Japan.
C3 Juntendo University; Nagoya University; Kansai Medical University;
   University of the Ryukyus; Tokyo Saiseikai Central Hospital; Fujita
   Health University; Tokyo Dental College; University of Tsukuba; Tohoku
   Medical & Pharmaceutical University; Kyorin University; Saitama Medical
   University
RP Kato, T (corresponding author), Juntendo Univ, Grad Sch Med, Dept Psychiat & Behav Sci, Tokyo, Japan.
EM tadafumi.kato@juntendo.ac.jp
RI Matsuo, Koji/IXN-9125-2023; Kato, Tadafumi/J-3583-2014; Kato,
   Masaki/L-6459-2019; Nemoto, Kiyotaka/C-4987-2013
OI Kato, Tadafumi/0000-0001-7856-3952; Kato, Masaki/0000-0001-6727-7272;
   Kishi, Taro/0000-0002-9237-2236; Nemoto, Kiyotaka/0000-0001-8623-9829
FX We thank Prof. Lakshmi Yatham and Prof. Gin Malhi for many suggestions
   on these guidelines. Their valuable suggestions were discussed in the
   chapter on limitations.
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NR 131
TC 4
Z9 4
U1 7
U2 8
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1323-1316
EI 1440-1819
J9 PSYCHIAT CLIN NEUROS
JI Psychiatry Clin. Neurosci.
PD NOV
PY 2024
VL 78
IS 11
BP 633
EP 645
DI 10.1111/pcn.13724
EA AUG 2024
PG 13
WC Clinical Neurology; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Psychiatry
GA L4U5O
UT WOS:001300246100001
PM 39194164
OA hybrid
DA 2025-06-11
ER

PT J
AU Thomson, SP
   Stump, CS
   Kurukulasuriya, LR
   Sowers, JR
AF Thomson, Stephen P.
   Stump, Craig S.
   Kurukulasuriya, L. Romayne
   Sowers, James R.
TI Adrenal steroids and the metabolic syndrome
SO CURRENT HYPERTENSION REPORTS
LA English
DT Article
ID SUBCLINICAL CUSHINGS-SYNDROME; FLOW-MEDIATED DILATION; BONE-MINERAL
   DENSITY; CARDIOVASCULAR RISK; INSULIN-RESISTANCE; HYPERCORTISOLEMIC
   DEPRESSION; ENDOTHELIAL DYSFUNCTION; PRIMARY ALDOSTERONISM; REPLACEMENT
   THERAPY; MUSCULAR STRENGTH
AB The many similarities between the metabolic syndrome and Cushing's syndrome led to the hypothesis that excess glucocorticoids (GC) are part of the pathogenesis linking their features. We review recent work that confirms the initial similarities (obesity, glucose intolerance, hypertension, and hyperlipidemia) and extends them to associated features of both syndromes (osteopenia, hypogonadism, leukocytosis, depression, and muscle weakness). Recent studies report that these features also occur in subclinical Cushing's syndrome, hypercortisolemic depression, and the transgenic overexpression of 11 beta-hydoxysteroid dehydrogenase type 1 (11 beta-HSD1) in mouse models of excess GC in adipose tissue. Reducing excess GC-in the clinical syndromes and in the mouse model-reverses many of these features. Because local tissue excess GC may have a central role in the pathogenesis of the metabolic syndrome, selective 11 beta-HSD1 inhibitors are under active development by several pharmaceutical companies.
C1 [Thomson, Stephen P.] So Arizona VA Hlth Care Syst, Tucson, AZ 85723 USA.
C3 US Department of Veterans Affairs; Veterans Health Administration (VHA);
   Southern Arizona Veterans Affairs Health Care System
RP Thomson, SP (corresponding author), So Arizona VA Hlth Care Syst, 3601 S 6th Ave, Tucson, AZ 85723 USA.
EM Stephen.Thomson@va.gov
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NR 58
TC 13
Z9 13
U1 0
U2 2
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1522-6417
EI 1534-3111
J9 CURR HYPERTENS REP
JI Curr. Hypertens. Rep.
PD DEC
PY 2007
VL 9
IS 6
BP 512
EP 519
DI 10.1007/s11906-007-0093-4
PG 8
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 271MQ
UT WOS:000253792900015
PM 18367016
DA 2025-06-11
ER

PT J
AU Chen, L
   Nini, W
   Jinmei, Z
   Jingmei, Y
AF Chen, Li
   Nini, Wang
   Jinmei, Zhang
   Jingmei, Yang
TI Implications of sleep disorders for periodontitis
SO SLEEP AND BREATHING
LA English
DT Review
DE Periodontitis; Sleep disorders; Obstructive sleep apnea; Inflammation;
   Signaling pathway
ID FACTOR-KAPPA-B; METABOLIC SYNDROME; PSYCHOLOGICAL STRESS; SYSTEMIC
   INFLAMMATION; CIRCADIAN EXPRESSION; OXIDATIVE STRESS; REACTIVE OXYGEN;
   APNEA SYNDROME; YOUNG-ADULTS; SHIFT WORK
AB Purpose Periodontitis is a chronic inflammatory disease caused by multi-factors. Sleep is a natural physiologic process, and the sleep duration, quality, and patterns might be associated with periodontitis. Meanwhile, periodontitis might in turn induce systemic inflammation and thus impact sleep in different ways as well. Methods To investigate the bidirectional relationship between sleep disorder and periodontitis, a literature search was conducted to reveal the interaction and possible mechanism between these two diseases. Results The results show that sleep disorders can affect the progression of periodontitis via some pathomechanisms, and periodontitis also has a reverse impact on sleep. Conclusion Although the epidemiologic and clinical trials found the possible associations between sleep disorder and periodontitis, their relationship is still not that explicit. Further studies are warranted to shed light on them, to improve preventive health care.
C1 [Chen, Li; Nini, Wang; Jinmei, Zhang; Jingmei, Yang] Sichuan Univ, West China Hosp Stomatol, Dept Periodont, State Key Lab Oral Dis, 14,Sect 3,Renmin South Rd, Chengdu 610041, Peoples R China.
   [Chen, Li; Nini, Wang; Jinmei, Zhang; Jingmei, Yang] Sichuan Univ, West China Hosp Stomatol, Natl Clin Res Ctr Oral Dis, Dept Periodont, 14,Sect 3,Renmin South Rd, Chengdu 610041, Peoples R China.
C3 Sichuan University; Sichuan University
RP Jingmei, Y (corresponding author), Sichuan Univ, West China Hosp Stomatol, Dept Periodont, State Key Lab Oral Dis, 14,Sect 3,Renmin South Rd, Chengdu 610041, Peoples R China.; Jingmei, Y (corresponding author), Sichuan Univ, West China Hosp Stomatol, Natl Clin Res Ctr Oral Dis, Dept Periodont, 14,Sect 3,Renmin South Rd, Chengdu 610041, Peoples R China.
EM yjm881222@hotmail.com
RI Yang, Jingmei/MIN-5567-2025
OI Yang, Jingmei/0000-0002-4318-9283
FU Sichuan Science and Technology Program [2022NSFSC1521]
FX Science & Technology Department of Sichuan Province provided financial
   support in the form of Sichuan Science and Technology Program
   (No.2022NSFSC1521). The sponsor had no role in the design or conduct of
   this research.
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NR 114
TC 6
Z9 6
U1 3
U2 39
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1520-9512
EI 1522-1709
J9 SLEEP BREATH
JI Sleep Breath.
PD OCT
PY 2023
VL 27
IS 5
BP 1655
EP 1666
DI 10.1007/s11325-022-02769-x
EA DEC 2022
PG 12
WC Clinical Neurology; Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Respiratory System
GA Z9SA9
UT WOS:000903208900001
PM 36547852
DA 2025-06-11
ER

PT J
AU Kilbourne, AM
   Goodrich, DE
   Lai, ZS
   Clogston, J
   Waxmonsky, J
   Bauer, MS
AF Kilbourne, Amy M.
   Goodrich, David E.
   Lai, Zongshan
   Clogston, Julia
   Waxmonsky, Jeanette
   Bauer, Mark S.
TI Life Goals Collaborative Care for Patients With Bipolar Disorder and
   Cardiovascular Disease Risk
SO PSYCHIATRIC SERVICES
LA English
DT Article
ID DEPRESSION; INTERVENTION; RATIONALE; SERVICES; ILLNESS; CENTERS; TRIAL;
   MODEL
AB Objective: This pilot study compared Life Goals Collaborative Care (LGCC) with enhanced treatment as usual in reducing cardiometabolic risk factors and improving outcomes for persons with bipolar disorder. Methods: Participants were randomly assigned to LGCC (N=34) or enhanced treatment as usual (N=34). LGCC included four weekly self-management sessions and monthly telephone contacts for six months thereafter. Enhanced treatment as usual included wellness mailings. Outcomes were blood pressure, body mass index (BMI), quality of life, functioning, and symptoms. Results: Compared with enhanced treatment as usual, LGCC was not associated with reductions in cardiometabolic risk factors in 12-month repeated-measures analyses. Among patients with a BMI of >= 30 or systolic blood pressure of >= 140, LGCC was associated with improvements in functioning (beta=-2.2 and beta =-3.8, respectively, p=.04) and reduced depressive symptoms (beta=-2.0 and -3.5, respectively, p=.04). Conclusions: Further research is needed to determine whether LGCC improves outcomes for patients with elevated cardiometabolic risk. (Psychiatric Services 63: 1234-1238, 2012; doi: 10.1176/appi.ps.201100528)
C1 [Kilbourne, Amy M.; Goodrich, David E.; Lai, Zongshan; Clogston, Julia] Vet Affairs VA Ann Arbor, Hlth Serv Res & Dev Ctr Clin Management Res, Ann Arbor, MI 48105 USA.
   [Waxmonsky, Jeanette] Univ Colorado, Sch Med, Dept Psychiat, Aurora, CO USA.
   [Bauer, Mark S.] VA Boston Healthcare Syst, Brockton, MA USA.
C3 University of Colorado System; University of Colorado Anschutz Medical
   Campus; Harvard University; Harvard University Medical Affiliates; US
   Department of Veterans Affairs; Veterans Health Administration (VHA); VA
   Boston Healthcare System
RP Kilbourne, AM (corresponding author), Vet Affairs VA Ann Arbor, Hlth Serv Res & Dev Ctr Clin Management Res, 2215 Fuller Ed, Ann Arbor, MI 48105 USA.
EM amykilbo@umich.edu
RI Waxmonsky, Jeanette/L-4739-2013
OI Waxmonsky, Jeanette/0000-0003-4198-9217; Goodrich,
   David/0000-0003-3232-2189
FU National Institute of Mental Health [R34 MH74509, R01 MH79994]; U.S.
   Department of Veterans Affairs (VA), Veterans Health Administration
FX This work was supported by the National Institute of Mental Health
   (grants R34 MH74509 and R01 MH79994) and the U.S. Department of Veterans
   Affairs (VA), Veterans Health Administration. The views expressed in
   this article are those of the authors and do not necessarily represent
   the views of the VA.
CR [Anonymous], 1996, SOCIAL FDN THOUGHT A
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NR 15
TC 42
Z9 43
U1 1
U2 3
PU AMER PSYCHIATRIC PUBLISHING, INC
PI ARLINGTON
PA 1000 WILSON BOULEVARD, STE 1825, ARLINGTON, VA 22209-3901 USA
SN 1075-2730
J9 PSYCHIAT SERV
JI Psychiatr. Serv.
PD DEC
PY 2012
VL 63
IS 12
BP 1234
EP 1238
DI 10.1176/appi.ps.201100528
PG 5
WC Health Policy & Services; Public, Environmental & Occupational Health;
   Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services; Public, Environmental & Occupational
   Health; Psychiatry
GA 049KS
UT WOS:000311982500012
PM 23203358
OA Green Accepted, Green Submitted
DA 2025-06-11
ER

PT J
AU Montoya-Estrada, A
   Veruete-Bedolla, DB
   Romo-Yañez, J
   Ortiz-Luna, GF
   Arellano-Eguiluz, A
   Najéra, N
   Ceballos, G
   Nieto-Velázquez, NG
   Ramos-Valencia, MA
   Cariño-Mancilla, N
   Valdez-Rodríguez, NL
   Flores-Pliego, A
   Espejel-Nuñez, A
   Reyes-Muñoz, E
AF Montoya-Estrada, Araceli
   Veruete-Bedolla, Daniela B.
   Romo-Yanez, Jose
   Ortiz-Luna, Guillermo F.
   Arellano-Eguiluz, Arturo
   Najera, Nayelli
   Ceballos, Guillermo
   Nieto-Velazquez, Nayeli Goreti
   Ramos-Valencia, Ma. Abel
   Carino-Mancilla, Norma
   Valdez-Rodriguez, Norma L.
   Flores-Pliego, Arturo
   Espejel-Nunez, Aurora
   Reyes-Munoz, Enrique
TI Markers of oxidative stress in postmenopausal women with metabolic
   syndrome
SO JOURNAL OF OBSTETRICS AND GYNAECOLOGY
LA English
DT Article
DE Oxidative stress; postmenopause; metabolic syndrome; protein damage;
   total antioxidant capacity; malondialdehyde
ID TOTAL ANTIOXIDANT CAPACITY; DISEASE RISK-FACTORS; LIPID PROFILE;
   MENOPAUSAL SYMPTOMS; OBESITY; ASSAY
AB During the postmenopausal period, there are metabolic alterations that predispose individuals to metabolic syndrome (MS), oxidative stress (OS), and the risk of developing cardiovascular diseases. We aimed to compare the concentrations of OS markers in postmenopausal women with and without MS. Malondialdehyde, carbonyl groups, and total antioxidant capacity (TAC) were quantified. We conducted a cross-sectional study: Group 1 (n = 42) included women without MS, and Group 2 (n = 58) comprised women with MS. Participants' age was similar between groups. Glucose, insulin, the homeostasis model assessment of insulin resistance, triglycerides, uric acid, and body mass index were significantly lower in postmenopausal women without MS. OS markers were significantly lower in Group 1 vs. Group 2: malondialdehyde, 31.32 +/- 14.93 vs. 40.27 +/- 17.62 pmol MDA/mg dry weight (p = .01); protein carbonylation, 6325 +/- 1551 vs. 7163 +/- 1029 pmol PC/mg protein (p = .0003); and TAC, 1497 +/- 297.3 vs. 1619 +/- 278.8 pmol Trolox equivalent/mg protein (p = .041). OS markers were significantly higher in postmenopausal women with MS. Impact statement What is already known on this subject? Oxidative stress has been implicated in numerous disease processes; however, information on the relationship between oxidative stress and metabolic syndrome among postmenopausal women remains limited. What do the results of this study add? Our results indicate that in postmenopausal Mexican women, oxidative stress markers were significantly lower in those without metabolic syndrome, whereas total antioxidant capacity was higher in those with metabolic syndrome, which could be explained as an antioxidant defense mechanism capable of neutralising excess oxidative damage markers. What are the implications of these findings for clinical practice and/or further research? This study is of interest to a broad audience because it compares the concentrations of oxidative stress markers in postmenopausal women with and without metabolic syndrome. Our study could support intervention with supplements or foods rich in antioxidants as lifestyle modifications in postmenopausal women with metabolic syndrome.
C1 [Montoya-Estrada, Araceli; Veruete-Bedolla, Daniela B.; Romo-Yanez, Jose; Reyes-Munoz, Enrique] Minist Hlth, Natl Inst Perinatol, Coordinat Gynecol & Perinatal Endocrinol, Mexico City, DF, Mexico.
   [Ortiz-Luna, Guillermo F.; Arellano-Eguiluz, Arturo] Natl Inst Perinatol, Peri & Postmenopause Clin, Minist Hlth, Mexico City, DF, Mexico.
   [Najera, Nayelli; Ceballos, Guillermo] Natl Polytech Inst, Higher Sch Med, Postgrad & Res Sect, Mexico City, DF, Mexico.
   [Nieto-Velazquez, Nayeli Goreti] Hosp Juarez Mex, Res Div, Minist Hlth, Mexico City, DF, Mexico.
   [Ramos-Valencia, Ma. Abel; Carino-Mancilla, Norma; Valdez-Rodriguez, Norma L.] Minist Hlth, Natl Inst Perinatol, Cent Lab, Mexico City, DF, Mexico.
   [Flores-Pliego, Arturo; Espejel-Nunez, Aurora] Minist Hlth, Dept Immunobiochem, Natl Inst Perinatol, Mexico City, DF, Mexico.
C3 Instituto Politecnico Nacional - Mexico
RP Reyes-Muñoz, E (corresponding author), Minist Hlth, Natl Inst Perinatol, Mexico City, DF, Mexico.
EM dr.enriquereyes@gmail.com
RI Espejel, Aurora/AAO-6510-2021; Flores-Pliego, Arturo/GPK-6349-2022;
   Romo-Yañez, Jose/GQP-2428-2022; Reyes-Muñoz, Enrique/U-9134-2019;
   Nájera, Nayelli/P-3146-2016; Ceballos, Guillermo/A-7507-2013
OI Ceballos, Guillermo/0000-0003-2155-3934; Flores Pliego,
   Arturo/0000-0001-7876-6098; ESPEJEL NUNEZ, AURORA/0000-0001-9087-8017;
   Montoya-Estrada, Araceli/0000-0001-5057-2793
FU Instituto Nacional de Perinatologia, 'Isidro Espinosa de los Reyes'
   [3210-10209-01-574-17]
FX This research was funded by Instituto Nacional de Perinatologia, 'Isidro
   Espinosa de los Reyes', grant number 3210-10209-01-574-17.
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NR 45
TC 3
Z9 3
U1 1
U2 3
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 0144-3615
EI 1364-6893
J9 J OBSTET GYNAECOL
JI J. Obstet. Gynaecol.
PD AUG 18
PY 2022
VL 42
IS 6
BP 2387
EP 2392
DI 10.1080/01443615.2022.2062223
EA MAY 2022
PG 6
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA 4W1YA
UT WOS:000804618400001
PM 35648871
DA 2025-06-11
ER

PT J
AU Cernelic-Bizjak, M
   Jenko-Praznikar, Z
AF Cernelic-Bizjak, Masa
   Jenko-Praznikar, Zala
TI Body dissatisfaction predicts inflammatory status in asymptomatic
   healthy individuals
SO JOURNAL OF HEALTH PSYCHOLOGY
LA English
DT Article
DE anti-inflammatory adiponectin; body image dissatisfaction; chronic
   disease; C-reactive protein; inflammation; interleukin-6; lifestyle
   intervention; obesity; tumour necrosis factor-
ID C-REACTIVE PROTEIN; PSYCHOLOGICAL STRESS; METABOLIC SYNDROME; RISK;
   SATISFACTION; SENSITIVITY; RESISTANCE; CYTOKINES; OBESITY
AB Body dissatisfaction may play some role in the pathophysiology of chronic diseases. This study examined relations between body dissatisfaction and circulating levels of inflammatory biomarkers C-reactive protein, tumour necrosis factor-, interleukin-6 and anti-inflammatory adiponectin, and to explore positive changes in relevant lifestyle behaviour after these associations. A total of 33 asymptomatic overweight men and women were evaluated at the baseline and after a 6-month lifestyle behaviour intervention. Body dissatisfaction emerged as an important predictor of pro- and anti-inflammatory biomarkers and may promote the production of inflammatory cytokines by reducing the level of anti-inflammatory and increasing the level of pro-inflammatory cytokine production.
C1 [Cernelic-Bizjak, Masa; Jenko-Praznikar, Zala] Univ Primorska, Izola, Slovenia.
C3 University of Primorska
RP Cernelic-Bizjak, M (corresponding author), Univ Primorska, Fac Hlth Sci, Dept Psychol, Dept Dietet,Fac Math Nat Sci & Informat Technol, Polje 42, Izola 6310, Slovenia.
EM masa.cernelic@upr.si
RI Jenko Praznikar, Zala/KVX-9901-2024
OI Jenko Praznikar, Zala/0000-0002-5217-8754; Cernelic-Bizjak,
   Masa/0000-0002-0537-0196
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NR 37
TC 3
Z9 4
U1 0
U2 11
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1359-1053
EI 1461-7277
J9 J HEALTH PSYCHOL
JI J. Health Psychol.
PD JAN
PY 2018
VL 23
IS 1
BP 25
EP 35
DI 10.1177/1359105316672923
PG 11
WC Psychology, Clinical
WE Social Science Citation Index (SSCI)
SC Psychology
GA FQ2MW
UT WOS:000418191600003
PM 28810361
DA 2025-06-11
ER

PT J
AU Zolghadrpour, MA
   Karimpour, F
   Jowshan, MR
   Imani, H
   Asghari, S
AF Zolghadrpour, Mohammad-Amin
   Karimpour, Farzad
   Jowshan, Mohammad-Reza
   Imani, Hossein
   Asghari, Somayyeh
TI The effect of a new developed synbiotic yogurt consumption on metabolic
   syndrome components, oxidative stress status, and some other
   cardiovascular disease risk factors in adults with metabolic syndrome: a
   study protocol for a randomized clinical trial
SO BMC NUTRITION
LA English
DT Article
DE Synbiotic yogurt; Probiotic; Metabolic syndrome; Oxidative stress;
   Cardiovascular disease; Clinical trial
ID PATHOPHYSIOLOGY
AB BackgroundMetabolic syndrome is recognized as one of the most common global health issues, which may cause numerous side effects. Studies have shown the favorable effects of probiotic supplements on glycemic indices, lipid profiles, and oxidative stress status. However, the number of studies investigating the effects of food products containing probiotics and prebiotics on metabolic diseases is limited. Limited evidence also shows that products containing Lactobacillus plantarum could affect metabolic alterations in chronic diseases. No previous study evaluated the impact of synbiotic yogurt containing Lactobacillus plantarum on people with metabolic syndrome. Therefore, the current study aims to investigate the effect of the newly developed synbiotic yogurt containing Lactobacillus plantarum, Lactobacillus pentosus, and Chloromyces marcosianos yeast on the components of metabolic syndrome, oxidative stress status, and some other risk factors for cardiovascular diseases in adults with metabolic syndrome.MethodsIn this study, 44 patients with metabolic syndrome will be randomly assigned to intervention and control groups in a randomized, double-blind, controlled clinical trial. Participants in the intervention group will consume 300 g of synbiotic yogurt daily, while those in the control group will consume 300 g of regular yogurt daily for 12 weeks. Anthropometric measurements, blood pressure, and biochemical parameters will be evaluated before and after the intervention.DiscussionThe management of the metabolic syndrome presents significant clinical challenges. While probiotic supplementation for these individuals has been considered, the consumption of probiotic-rich foods has received considerably less attention.
C1 [Zolghadrpour, Mohammad-Amin; Jowshan, Mohammad-Reza; Imani, Hossein; Asghari, Somayyeh] Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Clin Nutr, 44, Hojjatdoust St, Naderi St, Keshavarz Blvd, Tehran 141556117, Iran.
   [Karimpour, Farzad] Yasuj Univ Med Sci, Social Determinants Hlth Res Ctr, Yasuj, Iran.
C3 Tehran University of Medical Sciences; Yasouj University
RP Asghari, S (corresponding author), Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Clin Nutr, 44, Hojjatdoust St, Naderi St, Keshavarz Blvd, Tehran 141556117, Iran.
EM asghari.nut@gmail.com
RI Jowshan, Mohammadreza/ACQ-6216-2022; Imani, Hossein/AAU-7884-2020
OI Jowshan, Mohammad-Reza/0000-0001-8603-5674
CR Akhlaghi M, 2020, NUTR RES REV, V33, P1, DOI 10.1017/S0954422419000155
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NR 26
TC 2
Z9 2
U1 2
U2 5
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 2055-0928
J9 BMC NUTR
JI BMC Nutr.
PD JUN 6
PY 2023
VL 9
IS 1
AR 68
DI 10.1186/s40795-023-00723-y
PG 6
WC Nutrition & Dietetics
WE Emerging Sources Citation Index (ESCI)
SC Nutrition & Dietetics
GA I4AA7
UT WOS:001002209400001
PM 37280652
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Damiri, B
   Zidan, T
   Hamayel, D
   Saifi, M
AF Damiri, Basma
   Zidan, Thabet
   Hamayel, Dalia
   Saifi, Motaz
TI Tobacco smoking and the risk of eating behaviors and depression among
   Palestinian female university students
SO DISCOVER MENTAL HEALTH
LA English
DT Article
DE Eating disorders; Depression; Tobacco smoking; Waterpipe smoking; Binge
   Purge behavior; Female university students
ID SCOFF QUESTIONNAIRE; METABOLIC SYNDROME; CIGARETTE-SMOKING; ARABIC
   VERSION; ATTITUDES TEST; DISORDER; PREVALENCE; SYMPTOMS; ASSOCIATIONS;
   ADOLESCENTS
AB BackgroundTobacco smoking and eating disorders are often connected to concerns about body image and can be indicative of underlying mental health conditions, such as depression. In Palestinian society, females have a cultural belief that smoking can aid in weight loss. Societal pressure on body image may drive females to such risky behaviors. However, few studies have examined the link between smoking and eating disorder behaviors. We researched the prevalence of tobacco smoking among Palestinian female university students and its association with binge/purge behaviors and depression.MethodA cross-sectional research study was carried out at An-Najah National University. Female students [N = 642] completed anonymous surveys, sharing information about tobacco smoking and other substance use habits, answering questions from the Eating Attitude Test-26, the Sick (EAT-26), Control, One, Fat, and Food (SCOF) screening tests, and the Beck Depression Inventory.ResultsThe study reported a high prevalence of waterpipe smoking (24.4%) among Palestinian university female students, which exceeded the prevalence of cigarette smoking (4%). For the SCOF scale, 36.3% scored >= 2 points, indicating a screened positive for anorexia or bulimia nervosa; 40% struggled with binge-eating behavior, while only 7.8% had sought treatment for eating disorders. Additionally, 34.7% of the students experienced depression. The adjusted binary logistic regression model of risk factors for cigarette smoking has shown that cigarette smoking is significantly associated with self-induced vomiting (aOR = 6.075, p-value = 0.027), history for eating disorder treatment (aOR = 3.438, p-value = 0.047), e-cigarettes (aOR = 10.070, p-value = 0.001), waterpipe (aOR = 3.299, p-value = 0.022), energy drinks (aOR = 5.163, p-value = 0.003), moderate depression (aOR = 11.499, p-value = 0.010), and mild depression (aOR = 12.963, p-value = 0.003).ConclusionThe study revealed concerning results of tobacco smoking linked to depression, binge/purge behaviors, obesity, and various weight-control methods. These findings highlight the urgent need for targeted interventions through awareness campaigns, culturally tailored health education, implementation of mental health support for students, and provide accessible medical and psychological assistance to at-risk Palestinian female students.
C1 [Damiri, Basma] An Najah Natl Univ, Fac Med & Hlth Sci, Physiol Pharmacol & Toxicol Div, New Campus,Bldg 19,Off 3226,Box 7, Nablus, Palestine.
   [Zidan, Thabet; Hamayel, Dalia; Saifi, Motaz] An Najah Natl Univ, Sch Med & Hlth Sci, Dept Med, New Campus, Nablus, Palestine.
C3 An Najah National University; An Najah National University
RP Damiri, B (corresponding author), An Najah Natl Univ, Fac Med & Hlth Sci, Physiol Pharmacol & Toxicol Div, New Campus,Bldg 19,Off 3226,Box 7, Nablus, Palestine.; Saifi, M (corresponding author), An Najah Natl Univ, Sch Med & Hlth Sci, Dept Med, New Campus, Nablus, Palestine.
EM bdamiri@najah.edu; mtzsaifi@gmail.com
RI Damiri, Basma/AAA-3348-2019; Saifi, Motaz/ISS-4112-2023
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NR 58
TC 0
Z9 0
U1 2
U2 2
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
EI 2731-4383
J9 DISCOV MENT HEALTH
JI Discov. Ment. Heatlh
PD MAR 10
PY 2025
VL 5
IS 1
AR 34
DI 10.1007/s44192-025-00160-2
PG 12
WC Psychiatry
WE Emerging Sources Citation Index (ESCI)
SC Psychiatry
GA Z8B7D
UT WOS:001441099100002
PM 40064734
OA gold
DA 2025-06-11
ER

PT J
AU Martinac, M
   Babic, D
   Bevanda, M
   Vasilj, I
   Glibo, DB
   Karlovic, D
   Jakovljevic, M
AF Martinac, Marko
   Babic, Dragan
   Bevanda, Milenko
   Vasilj, Ivan
   Glibo, Danijela Bevanda
   Karlovic, Dalibor
   Jakovljevic, Miro
TI ACTIVITY OF THE HYPOTHALAMIC-PITUITARY-ADRENAL AXIS AND INFLAMMATORY
   MEDIATORS IN MAJOR DEPRESSIVE DISORDER WITH OR WITHOUT METABOLIC
   SYNDROME
SO PSYCHIATRIA DANUBINA
LA English
DT Article
DE depressive disorder; metabolic syndrome; inflammatory mediators; HPA
   axis; cortisol
ID C-REACTIVE PROTEIN; CORONARY-HEART-DISEASE; NECROSIS-FACTOR-ALPHA;
   INSULIN-RESISTANCE; VISCERAL FAT; CARDIOVASCULAR-DISEASE; IMMUNE
   ACTIVATION; NATIONAL-HEALTH; CHRONIC STRESS; YOUNG-ADULTS
AB Background: The aim of the present study was to explore the differences in serum CRP, IL-6, TNF-alpha, ACTH and cortisol among patients with major depressive disorder with or without metabolic syndrome (MS) compared to a healthy control group.
   Subjects and methods: The MDD study group consisted of 80 patients (mean age of 50.03 +/- 9.55 years). The control group was recruited from the hospital personnel and it consisted of 40 examinees (mean age of 47.20 +/- 7.99 years). All patients who participated in the study were diagnosed with depressive disorder using MINI questionnaire, and Hamilton rating scale for depression. Diagnosis of the metabolic syndrome was set by NCEP ATP III criteria.
   Results: Examinees with depression but without MS had significantly more cortisol concentration when compared to the control group. CRP was significantly higher in the MDD group when compared to the control group and in MDD+MS group when compared to the control group. IL6 serum levels were significantly higher in the MDD group when compared to the healthy control group, and in MDD+MS group when compared to the healthy control group. ACTH had significant independent predictive values for abdominal obesity. Levels of TNF-alpha were statistically significant independent predictors for hyperglycaemia. Statistically significant predictive values for MDD were found for cortisol, and IL-6.
   Conclusion: Results shown here emphasise the importance of neuroendocrine and inflammatory factors in pathogenesis of depressive disorder and MS. Further prospective research is necessary to clarify possible causal relationship between depression and MS. It is necessary to investigate the possibility of a joint biological mechanism in pathogenesis of these two disorders with the special attention given to the disturbances in the immune system.
C1 [Martinac, Marko] Mostar Hlth Ctr, Mostar Ctr Mental Hlth, Mostar 88000, Bosnia & Herceg.
   [Babic, Dragan] Mostar Univ Hosp, Clin Dept Psychiat, Mostar, Bosnia & Herceg.
   [Bevanda, Milenko; Glibo, Danijela Bevanda] Mostar Univ Hosp, Clin Dept Internal Med, Mostar, Bosnia & Herceg.
   [Karlovic, Dalibor] Sestre Milosrdnice Univ Hosp Ctr, Clin Dept Psychiat, Zagreb, Croatia.
   [Martinac, Marko; Babic, Dragan; Bevanda, Milenko; Vasilj, Ivan] Univ Mostar, Sch Med, Mostar, Bosnia & Herceg.
   [Jakovljevic, Miro] Univ Hosp Ctr Zagreb, Clin Dept Psychiat, Zagreb, Croatia.
C3 University of Mostar; University of Mostar; University of Mostar;
   University of Zagreb; University of Mostar; University of Zagreb;
   UNIVERSITY ZAGREB HOSPITAL
RP Martinac, M (corresponding author), Mostar Hlth Ctr, Mostar Ctr Mental Hlth, Mostar 88000, Bosnia & Herceg.
EM marko.martinac@tel.net.ba
RI Vasilj, Ivan/LKK-2729-2024
OI Martinac, Marko/0000-0001-9144-6427
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NR 116
TC 23
Z9 26
U1 0
U2 13
PU MEDICINSKA NAKLADA
PI ZAGREB
PA VLASKA 69, HR-10000 ZAGREB, CROATIA
SN 0353-5053
EI 1849-0867
J9 PSYCHIAT DANUB
JI Psychiatr. Danub.
PY 2017
VL 29
IS 1
BP 39
EP 50
DI 10.24869/psyd.2017.39
PG 12
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA EQ3RO
UT WOS:000397990400006
PM 28492214
OA Green Published
DA 2025-06-11
ER

PT J
AU Chang, WH
   Cheng, SH
   Sun, ZJ
   Lee, IH
   Lee, CT
   Chen, KC
   Tsai, CH
   Yang, YK
   Yang, YC
AF Chang, Wei-Hung
   Cheng, Shu-Hui
   Sun, Zih-Jie
   Lee, I-Hui
   Lee, Chih-Ting
   Chen, Kao-Chin
   Tsai, Chung-Hung
   Yang, Yen-Kuang
   Yang, Yi-Ching
TI The psychosocial indicators related to neuroticism in both sexes: A
   study of incoming university students
SO KAOHSIUNG JOURNAL OF MEDICAL SCIENCES
LA English
DT Article
DE Depression; Internet addiction; Neuroticism; Sleep; Social support
ID METABOLIC RISK-FACTORS; SOCIAL SUPPORT; PSYCHIATRIC MORBIDITY;
   YOUNG-ADULTS; PERSONALITY; LIFE; DEPRESSION; DISORDERS; COMMUNITY;
   HEALTH
AB Neuroticism may have great impact on mental and physical health in both sexes. The aims of this study were to explore whether relationships between neuroticism scores and psychosocial indicators as well as metabolic syndrome in a population of incoming university students existed in the different sexes. In total, 4266 incoming students were included in this study. The test battery comprised a self-administered structured questionnaire, including the neuroticism subscale of the Maudsley Personality Inventory, the 12-item Chinese Health Questionnaire, the Chinese Internet Addiction Scale-Revision, the measurement of support functions, and the Pittsburgh Sleep Quality Index. Multivariate logistic regression showed that higher Pittsburgh Sleep Quality Index scores, higher Chinese Internet Addiction Scale-Revision scores, and higher 12-item Chinese Health Questionnaire scores were significantly correlated with neuroticism in both sexes, but lower perceived routine support: measurement of support functions scores were associated only with the male participants. No significant differences were found in terms of body mass index or other metabolic profiles. Individuals with poorer mental health and a poorer personal lifestyle had higher neuroticism scores, and sex effects may influence the scale of perceived social support in the neuroticism group. However, the lack of an association between neuroticism score and metabolic syndrome may be due to the recruitment of younger participants in this study. Copyright (C) 2015, Kaohsiung Medical University. Published by Elsevier Taiwan LLC. All rights reserved.
C1 [Chang, Wei-Hung] Natl Cheng Kung Univ Hosp, Dept Psychiat, Dou Liou Branch, Yunlin, Taiwan.
   [Cheng, Shu-Hui; Lee, I-Hui; Chen, Kao-Chin; Yang, Yen-Kuang] Natl Cheng Kung Univ, Coll Med, Natl Cheng Kung Univ Hosp, Dept Psychiat, Tainan 70403, Taiwan.
   [Cheng, Shu-Hui; Lee, I-Hui] Natl Cheng Kung Univ, Off Student Affairs, Tainan 70403, Taiwan.
   [Sun, Zih-Jie; Lee, Chih-Ting; Tsai, Chung-Hung; Yang, Yi-Ching] Natl Cheng Kung Univ, Coll Med, Dept Family Med, Tainan 70403, Taiwan.
   [Lee, I-Hui; Chen, Kao-Chin; Yang, Yen-Kuang] Natl Cheng Kung Univ, Addict Res Ctr, Tainan 70403, Taiwan.
   [Yang, Yen-Kuang; Yang, Yi-Ching] Natl Cheng Kung Univ, Coll Med, Inst Behav Med, Tainan 70403, Taiwan.
   [Yang, Yi-Ching] Natl Cheng Kung Univ, Coll Med, Dept Publ Hlth, Tainan 70403, Taiwan.
C3 National Cheng Kung University; National Cheng Kung University Hospital;
   National Cheng Kung University; National Cheng Kung University Hospital;
   National Cheng Kung University; National Cheng Kung University; National
   Cheng Kung University; National Cheng Kung University; National Cheng
   Kung University
RP Yang, YC (corresponding author), Natl Cheng Kung Univ, Coll Med, Dept Family Med, 138 Sheng Li Rd, Tainan 70403, Taiwan.
EM yiching@mail.ncku.edu.tw
RI Chang, Hui/AGD-4270-2022; Chen, Yun-Yu/IXO-3895-2023; Yang,
   Yi-Ching/C-7033-2014
OI Yang, Yi-Ching/0000-0003-1391-8040
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NR 41
TC 4
Z9 7
U1 1
U2 22
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1607-551X
EI 2410-8650
J9 KAOHSIUNG J MED SCI
JI Kaohsiung J. Med. Sci.
PD APR
PY 2015
VL 31
IS 4
BP 208
EP 214
DI 10.1016/j.kjms.2014.12.009
PG 7
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA CE8JX
UT WOS:000352089600007
PM 25835278
OA gold
DA 2025-06-11
ER

PT J
AU Hemingway, H
   Shipley, M
   Mullen, MJ
   Kumari, M
   Brunner, E
   Taylor, M
   Donald, AE
   Deanfield, JE
   Marmot, M
AF Hemingway, H
   Shipley, M
   Mullen, MJ
   Kumari, M
   Brunner, E
   Taylor, M
   Donald, AE
   Deanfield, JE
   Marmot, M
TI Social and psychosocial influences on inflammatory markers and vascular
   function in civil servants (The Whitehall II study)
SO AMERICAN JOURNAL OF CARDIOLOGY
LA English
DT Article
ID CORONARY-HEART-DISEASE; ENDOTHELIAL DYSFUNCTION; METABOLIC SYNDROME;
   YOUNG-ADULTS; STRESS; ARTERY; RISK; ATHEROSCLEROSIS; FIBRINOGEN; MONKEYS
AB Social position and psychosocial factors are associated with coronary disease, but the underlying pathophysiologic mechanisms remain unclear. In a sample of 283 nonsmokers, we found that social position was inversely associated with interleukin-6 and C-reactive protein and that participants with mild depression had impaired endothelial function. (C) 2003 by Excerpta Medica, Inc.
C1 UCL, Sch Med, Dept Epidemiol & Publ Hlth, Int Ctr Hlth & Soc, London, England.
   Great Ormond St Hosp Sick Children, Dept Publ Hlth Res, Westminster Primary Care Trust, London WC1N 3JH, England.
   Great Ormond St Hosp Sick Children, Vasc Physiol Unit, London WC1N 3JH, England.
C3 University of London; University College London; UCL Medical School;
   University of London; University College London; Great Ormond Street
   Hospital for Children NHS Foundation Trust; University of London;
   University College London; Great Ormond Street Hospital for Children NHS
   Foundation Trust
RP Hemingway, H (corresponding author), UCL, Sch Med, Dept Epidemiol & Publ Hlth, Int Ctr Hlth & Soc, London, England.
EM h.hemingway@public-health.ucl.ac.uk
RI Deanfield, John/C-5178-2008; Brunner, Eric/H-2114-2011; Marmot,
   Michael/Y-3920-2019; Hemingway, Harry/C-1219-2009
OI Marmot, Michael/0000-0002-2431-6419; Kumari, Meena/0000-0001-9716-1035;
   Brunner, Eric/0000-0002-0595-4474; Deanfield, John/0000-0001-8806-6052;
   Hemingway, Harry/0000-0003-2279-0624
FU Medical Research Council [G0100222, G19/35, G8802774] Funding Source:
   Medline; NHLBI NIH HHS [2R01 HL36310] Funding Source: Medline; NIA NIH
   HHS [R01 AG13196-02] Funding Source: Medline
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NR 20
TC 110
Z9 124
U1 1
U2 9
PU EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
PI BRIDGEWATER
PA 685 ROUTE 202-206 STE 3, BRIDGEWATER, NJ 08807 USA
SN 0002-9149
J9 AM J CARDIOL
JI Am. J. Cardiol.
PD OCT 15
PY 2003
VL 92
IS 8
BP 984
EP 987
DI 10.1016/S0002-9149(03)00985-8
PG 4
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 732DW
UT WOS:000185926400019
PM 14556880
DA 2025-06-11
ER

PT J
AU Kane, HS
   Brown, JA
   Nelson, JA
   Cha, LH
   Schetter, CD
   Robles, TF
AF Kane, Heidi S.
   Brown, Joni A.
   Nelson, Jackie A.
   Cha, Leah
   Schetter, Christine Dunkel
   Robles, Theodore F.
TI Social Relationships and Cardiometabolic Risk in Low-Income Mothers
   Following Birth
SO HEALTH PSYCHOLOGY
LA English
DT Article
DE social relationships; cardiometabolic health; maternal health;
   neighborhood cohesion; social support
ID CARDIOVASCULAR-DISEASE; DYADIC ADJUSTMENT; AMERICAN; SUPPORT;
   ASSOCIATION; MULTILEVEL; FAMILISM; STRESS; NUMBER; WOMEN
AB Objective: The social environment influences women's cardiometabolic health across the lifespan, but little is known about women's cardiometabolic health in the time surrounding birth. The goals of the present study were to use a person-centered approach to characterize social relationship profiles of low-to-middle income Black, Latina, and White women and test associations with postpartum cardiometabolic risk. Method: Data were collected by the Community Child Health Network (CCHN), a community-based participatory research network (Nanalytic sample = 1,328). Home interviews at 1, 6, and 12 months after birth assessed the quality and functioning of social relationships at multiple levels including intimate partner, family, social network, and neighborhood. Latent profile analysis (LPA) was used to identify profiles of women who shared similar social characteristics. Standardized cardiometabolic risk and clinical cutoff risk indices were computed from measures of blood pressure, waist circumference, glycosylated hemoglobin, and HDL cholesterol collected at 6- and 12-month post birth. Logistic regression was used to determine associations of profile membership with sociodemographic characteristics and cardiometabolic risk. Results: LPA analyses revealed four profiles: (a) strong relationships, (b) strong partner/weak network, (c) weak partner/strong network, and (d) weak relationships. Women with a higher standardized cardiometabolic risk score were 1.72 and 1.81 times more likely to be in the weak partner/strong network profile than the strong relationships or strong partner/weak network profiles. Cardiometabolic clinical cutoff scores were unrelated to profile membership. Conclusion: These findings have implications for the identification of women for intervention before, during, or after pregnancy to reduce cardiometabolic risk.
C1 [Kane, Heidi S.; Nelson, Jackie A.] Univ Texas Dallas, Dept Psychol, 800 West Campbell Rd,GR 41, Richardson, TX 75080 USA.
   [Brown, Joni A.; Cha, Leah; Schetter, Christine Dunkel; Robles, Theodore F.] Univ Calif Los Angeles, Dept Psychol, Los Angeles, CA USA.
C3 University of Texas System; University of Texas Dallas; University of
   California System; University of California Los Angeles
RP Kane, HS (corresponding author), Univ Texas Dallas, Dept Psychol, 800 West Campbell Rd,GR 41, Richardson, TX 75080 USA.
EM Heidi.kane@utdallas.edu
RI Robles, Theodore/MZS-2465-2025
FU Eunice Kennedy Shriver National Institute of Child Health and Human
   Development [U01 HD044207, U01 HD044219, U01 HD044226, U01 HD044245, U01
   HD044253, U01 HD054791, U01 HD054019, U01 HD044226-05S1, U01
   HD044245-06S1, R03 HD59584]; National Institute of Nursing Research [U01
   NR008929]
FX This article is based on data collected by the Child Community Health
   Network (CCHN), supported through cooperative agreements with the Eunice
   Kennedy Shriver National Institute of Child Health and Human Development
   (Grants U01 HD044207, U01 HD044219, U01 HD044226, U01 HD044245, U01
   HD044253, U01 HD054791, U01 HD054019, U01 HD044226-05S1, U01
   HD044245-06S1, R03 HD59584) and the National Institute of Nursing
   Research (Grant U01 NR008929). We thank Ryan Ottman for helping with the
   tables. We have no known conflicts of interest to disclose. The
   preregistered study is available at https:/osf.io/yvdr2 (Kane et al.,
   2023).
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NR 49
TC 1
Z9 1
U1 1
U2 1
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 0278-6133
EI 1930-7810
J9 HEALTH PSYCHOL
JI Health Psychol.
PD MAY
PY 2025
VL 44
IS 5
SI SI
BP 426
EP 435
DI 10.1037/hea0001422
PG 10
WC Psychology, Clinical; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology
GA 1JL5G
UT WOS:001466473600006
PM 40232778
DA 2025-06-11
ER

PT J
AU Kucerova, J
   Babinska, Z
   Horska, K
   Kotolova, H
AF Kucerova, Jana
   Babinska, Zuzana
   Horska, Katerina
   Kotolova, Hana
TI The common pathophysiology underlying the metabolic syndrome,
   schizophrenia and depression. A review
SO BIOMEDICAL PAPERS-OLOMOUC
LA English
DT Review
DE metabolic syndrome; schizophrenia; depression; sex/gender differences;
   adipokines; leptin; adiponectin; resistin; AFABP
ID NECROSIS-FACTOR-ALPHA; MAJOR DEPRESSION; ENDOCANNABINOID SYSTEM;
   1ST-EPISODE SCHIZOPHRENIA; GENDER-DIFFERENCES; CHRONIC OLANZAPINE;
   BIPOLAR DISORDER; LEPTIN RECEPTOR; SEX-DIFFERENCES; MOOD DISORDERS
AB Background. There is a growing interest in metabolic alterations in patients with psychiatric disorders due to their increased risk for metabolic syndrome (MetS) development. Inflammation is known to underlie the pathophysiology of schizophrenia and depression as well as MetS. Vulnerability factors for schizophrenia/depression and MetS hence appear to be shared.
   Methods and Results. Based on a Web of Science search, this review examines current evidence for MetS pathophysiology involving dysregulation of adipose tissue signaling - adipokines and pro-inflammatory cytokine, both also known to be aberrant in schizophrenia/depression. Further, gender differences in the incidence and course of schizophrenia/depression were reported. The disturbances linked to the MetS are also described. Therefore, this review further maps the gender differences in the psychiatric-metabolic comorbidities.
   Conclusion. There is evidence supporting a pathological predisposition to MetS in both schizophrenia and depression in both humans and animal models. This predisposition is dramatically enhanced by antipsychotic medication. Further, there are gender differences from clinical findings suggesting women with schizophrenia/ depression are more vulnerable to MetS development. This has not yet been assessed in animal studies. We suggest further validation of existing schizophrenia and depression animal models for the assessment of metabolic disturbances to provide tools for developing new antipsychotics and antidepressants with "metabolically inert" profile or improving the metabolic status in schizophrenic/depressed patients.
C1 [Kucerova, Jana; Babinska, Zuzana] Masaryk Univ, Cent European Inst Technol CEITEC, Brno, Czech Republic.
   [Kucerova, Jana; Babinska, Zuzana] Masaryk Univ, Fac Med, Dept Pharmacol, Brno, Czech Republic.
   [Horska, Katerina; Kotolova, Hana] Univ Brno, Fac Pharm Vet & Pharmaceut, Dept Human Pharmacol & Toxicol, Brno, Czech Republic.
C3 Masaryk University Brno; Masaryk University Brno
RP Kucerova, J (corresponding author), Masaryk Univ, Cent European Inst Technol CEITEC, Brno, Czech Republic.
EM jkucer@med.muni.cz
RI Horska, Katerina/AAP-4585-2020; Ruda-Kucerova, Jana/D-5117-2012
OI Ruda-Kucerova, Jana/0000-0002-1846-0799
FU project of specific research at the Masaryk University
   [MUNI/A/0886/2013]; Project of the Internal Grant Agency (IGA) VFU Brno
   [48/2014/FaF]; project "CEITEC - Central European Institute of
   Technology" from European Regional Development Fund
   [CZ.1.05/1.1.00/02.0068]
FX This work was supported by the project of specific research at the
   Masaryk University (MUNI/A/0886/2013), Project of the Internal Grant
   Agency (IGA) VFU Brno (48/2014/FaF) and the project "CEITEC - Central
   European Institute of Technology" (CZ.1.05/1.1.00/02.0068) from European
   Regional Development Fund.
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NR 108
TC 40
Z9 42
U1 0
U2 28
PU PALACKY UNIV, MEDICAL FAC
PI OLOMOUC
PA CENTRAL LIBRARY, HNEVOTINSKA 3, OLOMOUC, 00000, CZECH REPUBLIC
SN 1213-8118
EI 1804-7521
J9 BIOMED PAP
JI Biomed. Pap-Olomouc
PY 2015
VL 159
IS 2
BP 208
EP 214
DI 10.5507/bp.2014.060
PG 7
WC Engineering, Biomedical; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering; Research & Experimental Medicine
GA CO4KF
UT WOS:000359128900007
PM 25485531
OA Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Cardona, F
   Tunez, I
   Tasset, I
   Montilla, P
   Collantes, E
   Tinahones, FJ
AF Cardona, F.
   Tunez, I.
   Tasset, I.
   Montilla, P.
   Collantes, E.
   Tinahones, F. J.
TI Fat overload aggravates oxidative stress in patients with the metabolic
   syndrome
SO EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
LA English
DT Article
DE fat overload; metabolic syndrome; oxidative stress
ID DENSITY-LIPOPROTEIN; INSULIN-RESISTANCE; OXIDANT STRESS; NITRIC-OXIDE;
   OBESITY; DYSFUNCTION; MECHANISMS; INJURY; MODEL
AB Background Patients with the metabolic syndrome have greater levels of oxidative stress. However, as the response of markers of this stress to a fat overload is unknown, we evaluated certain markers of oxidative stress in these patients.
   Material and methods The study population comprised 93 subjects (70 men and 23 women): 13 healthy people (controls) with a mean age of 48.81 +/- 9.01 years and 80 patients with the metabolic syndrome (mean age, 43.25 +/- 11.55 years), according to the Adult Treatment Panel III criteria. All the participants were given a 60 g fat overload (Supracal). Three hours later the following biomarkers of oxidative stress were measured: lipid peroxidation products, protein carbonyl groups, reduced glutathione, glutathione peroxidase (GSH-Px), catalase, superoxide dismutase, glutathione reductase (GSH-Road) and glutathione S-transferase. The levels of oxidized glutathione (GSSG) were calculated.
   Results Compared with the controls, the patients showed greater baseline oxidative stress, higher levels of lipid peroxidation products and oxidized glutathione, and lower levels of reduced glutathione, glutathione peroxidase activity, glutathione reductase and glutathione transferase. This stress was more intense after the subjects received a fat overload, more so in the patients who experienced a greater reduction in GSHpx and GSHrd antioxidant activity and a greater increase in the levels of carbonylated proteins and lipoperoxides than the controls.
   Conclusions Patients with the metabolic syndrome have greater oxidative stress than healthy people. The variation in markers of this stress after a fat overload was even more pronounced in the patients.
C1 [Cardona, F.; Tinahones, F. J.] Hosp Clin Virgen Victoria, Serv Endocrinol, Malaga 29010, Spain.
   [Cardona, F.; Tinahones, F. J.] Inst Salud Carlos III, Ciber Fisiopatol Obesidad & Nutr CB06 03, Malaga, Spain.
   [Tunez, I.; Tasset, I.; Montilla, P.] Univ Cordoba, Fac Med, Dept Bioquim & Biol Mol, E-14071 Cordoba, Spain.
   [Collantes, E.] Univ Cordoba, Dept Med, E-14004 Cordoba, Spain.
   [Collantes, E.] Hosp Univ Reina Sofia Cordoba, Serv Reumatol, Cordoba 14004, Spain.
C3 CIBER - Centro de Investigacion Biomedica en Red; CIBEROBN; Instituto de
   Salud Carlos III; Universidad de Cordoba; Universidad de Cordoba;
   Hospital Universitario Reina Sofia - Cordoba
RP Cardona, F (corresponding author), Hosp Clin Univ Virgen Victoria, Lab Invest, Campus Teatinos S-N, Malaga 29010, Spain.
EM fernandocardonadiaz@gmail.com
RI Cardona, Fernando/AAG-7835-2019; Collantes-Estevez, Eduardo/M-9549-2019;
   Tinahones, Francisco/AAB-2882-2020; Cuevas, Inmaculada/R-4509-2019;
   Cardona, Fernando/H-6022-2015
OI Cardona, Fernando/0000-0003-4460-6824; Collantes Estevez,
   Eduardo/0000-0002-7647-6289; Tinahones, Francisco J/0000-0001-6871-4403
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NR 32
TC 49
Z9 53
U1 0
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0014-2972
EI 1365-2362
J9 EUR J CLIN INVEST
JI Eur. J. Clin. Invest.
PD JUL
PY 2008
VL 38
IS 7
BP 510
EP 515
DI 10.1111/j.1365-2362.2008.01959.x
PG 6
WC Medicine, General & Internal; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Research & Experimental Medicine
GA 312QN
UT WOS:000256686000008
PM 18489583
DA 2025-06-11
ER

PT J
AU Ling, JY
   Anderson, LM
   Ji, H
AF Ling, Jiying
   Anderson, Laura M.
   Ji, Hong
TI Self-management training for Chinese obese children at risk for
   metabolic syndrome: Effectiveness and implications for school health
SO SCHOOL PSYCHOLOGY INTERNATIONAL
LA English
DT Article
DE China; metabolic syndrome; obesity; school-based intervention; student
   health
ID WAIST CIRCUMFERENCE DISTRIBUTION; LIFE-STYLE INTERVENTION; CHILDHOOD
   OBESITY; PHYSICAL-ACTIVITY; ACADEMIC-PERFORMANCE; MENTAL-HEALTH;
   BODY-WEIGHT; ADOLESCENTS; ASSOCIATION; OVERWEIGHT
AB This article reviews the results of a school-based self-management intervention for Chinese obese children at risk for metabolic syndrome. Twenty-eight Chinese obese children (M age=10 years) and their parents participated in the study. Metabolic syndrome risk factors were measured pre- and post-intervention. The risk factors included Body Mass Index, waist circumstance, systolic blood pressure, diastolic blood pressure, triglycerides, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, High-sensitivity C-reactive Protein, fasting plasma glucose, and fasting blood insulin. After 6 months of school-based self-management intervention, all risk factors with the exception of triglycerides and fasting plasma glucose changed significantly in the healthful direction (p<0.01). This pilot study offers promising implications for school interventions that are delivered by school-based practitioners collaborating with parents, teachers, and children. An individualized program based on a self-care and -management framework may have utility as a relatively cost-effective, school-based intervention to improve children's health.
C1 [Ling, Jiying] Michigan State Univ, Coll Nursing, E Lansing, MI 48824 USA.
   [Anderson, Laura M.] SUNY Buffalo, PULSE Hlth Weight Res Team, Sch Nursing, Buffalo, NY 14260 USA.
   [Ji, Hong] Qianfoshan Hosp, Jinan, Peoples R China.
C3 Michigan State University; State University of New York (SUNY) System;
   University at Buffalo, SUNY; Shandong First Medical University &
   Shandong Academy of Medical Sciences
RP Ji, H (corresponding author), Shandong Univ, Qianfoshan Hosp, Jinan 250014, Shandong, Peoples R China.
EM lingjiying@gmail.com
RI Ling, Jiying/R-5914-2019
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NR 55
TC 3
Z9 3
U1 0
U2 20
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0143-0343
EI 1461-7374
J9 SCHOOL PSYCHOL INT
JI Sch. Psychol. Int.
PD APR
PY 2015
VL 36
IS 2
SI SI
BP 189
EP 206
DI 10.1177/0143034314564613
PG 18
WC Psychology, Educational
WE Social Science Citation Index (SSCI)
SC Psychology
GA CE9XX
UT WOS:000352198000005
DA 2025-06-11
ER

PT J
AU Kang, JH
   Moser, DK
   Lennie, TA
   Chung, ML
   Thomas, DT
   Biddle, MJ
AF Kang, Junghee
   Moser, Debra K.
   Lennie, Terry A.
   Chung, Misook L.
   Thomas, D. Travis
   Biddle, Martha J.
TI Diet Quality Mediates the Relationship Between Chronic Stress and
   Inflammation in Patients With Metabolic Syndrome
SO JOURNAL OF CARDIOVASCULAR NURSING
LA English
DT Article
DE cardiovascular disease; C-reactive protein; Healthy Eating Index;
   perceived stress
ID LOW-GRADE INFLAMMATION; HEALTHY EATING INDEX; C-REACTIVE PROTEIN;
   PERCEIVED STRESS; FOOD; RELIABILITY; VALIDITY; SCALE
AB BackgroundChronic stress is associated with promotion of inflammation and development of metabolic syndrome, as well as deterioration of diet quality. Inflammation can be modified by changes in dietary intake.ObjectiveThe aim of this study was to test the hypothesis that diet quality mediates the relationship of chronic stress with inflammation in patients with metabolic syndrome.MethodsParticipants with metabolic syndrome (n = 73, 62 +/- 12 years old, 71% female) completed questionnaires on chronic stress (Perceived Stress Scale-10) and diet quality (Healthy Eating Index-2020). The Perceived Stress Scale-10 was dichotomized. The Healthy Eating Index-2020 score was used as a continuous variable, and higher scores indicate better diet quality. Inflammation was assessed using plasma high-sensitivity C-reactive protein (log-transformed). We used PROCESS in SPSS to test the hypothesis.ResultsPatients in the higher stress group had lower Healthy Eating Index-2020 scores (worse diet quality) than those in the lower stress group (57 +/- 13 vs 64 +/- 10, P = .01). Diet quality mediated the relationship between chronic stress and inflammation (indirect effect, 0.211; 95% bootstrap confidence interval, 0.006-0.496). Higher stress was associated with lower diet quality (effect, -7.152; 95% confidence interval, -13.168 to -1.137) that was associated with increased inflammation (effect, -0.030; 95% confidence interval, -0.052 to -0.007).ConclusionsOur findings show the important role of diet quality in the relationship of chronic stress with inflammation in patients with metabolic syndrome. Healthcare providers should encourage patients with higher stress to improve diet quality, which can decrease inflammation.
C1 [Kang, Junghee; Moser, Debra K.; Lennie, Terry A.; Chung, Misook L.; Biddle, Martha J.] Univ Kentucky, Coll Nursing, 2201 Regency Rd, Ste 403, Lexington, KY 40503 USA.
   [Thomas, D. Travis] Univ Kentucky, Coll Hlth Sci, Dept Athlet Training & Clin Nutr, Lexington, KY USA.
C3 University of Kentucky; University of Kentucky
RP Kang, JH (corresponding author), Univ Kentucky, Coll Nursing, 2201 Regency Rd, Ste 403, Lexington, KY 40503 USA.
EM junghee.kang@uky.edu; dmoser@uky.edu; terry.lennie@uky.edu;
   misook.chung@uky.edu; david.t.thomas@uky.edu; Mjbidd0@uky.edu
RI Chung, Misook/AAG-2499-2021; Biddle, Martha/AGR-6563-2022
OI Kang, JungHee/0000-0003-2533-9900
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NR 54
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0889-4655
EI 1550-5049
J9 J CARDIOVASC NURS
JI J. Cardiovasc. Nurs.
PD MAR-APR
PY 2025
VL 40
IS 2
BP 124
EP 132
DI 10.1097/JCN.0000000000001072
PG 9
WC Cardiac & Cardiovascular Systems; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Cardiovascular System & Cardiology; Nursing
GA W1J1E
UT WOS:001416213200012
PM 38192030
OA Bronze
DA 2025-06-11
ER

PT J
AU Sarwar, H
   Rafiqi, SI
   Ahmad, S
   Jinna, S
   Khan, SA
   Karim, T
   Qureshi, O
   Zahid, ZA
   Elhai, JD
   Levine, JC
   Naqvi, SJ
   Jaume, JC
   Imam, S
AF Sarwar, Haider
   Rafiqi, Shafiya Imtiaz
   Ahmad, Showkat
   Jinna, Sruthi
   Khan, Sawleha Arshi
   Karim, Tamanna
   Qureshi, Omar
   Zahid, Zeeshan A.
   Elhai, Jon D.
   Levine, Jason C.
   Naqvi, Shazia J.
   Jaume, Juan C.
   Imam, Shahnawaz
TI Hyperinsulinemia Associated Depression
SO CLINICAL MEDICINE INSIGHTS-ENDOCRINOLOGY AND DIABETES
LA English
DT Review
DE Diabetes mellitus; depression; hyperinsulinism
ID PITUITARY-ADRENAL AXIS; INSULIN-RESISTANCE; MEDICATION ADHERENCE;
   METABOLIC SYNDROME; DIABETES-MELLITUS; BLOOD-PRESSURE; SELF-CARE;
   TYPE-2; CORTISOL; NOREPINEPHRINE
AB Hyperinsulinemia promotes fat accumulation, causing obesity. Being an inflammatory state, obesity can induce further inflammation and is a risk factor for HPA (hypothalamic pituitary axis) dysregulation through hypercortisolism-related hyperglycemia. In another hypothesis, the sympathetic nervous system (SNS) plays a significant role in the regulation of hormone secretion from the pancreas such as an increase in catecholamines and glucagon as well as a decrease in plasma insulin levels, a disruption on SNS activity increases insulin levels, and induces glycogenolysis in the liver and lipolysis in adipose tissue during hypoglycemia. Hyperglycemia-hyperinsulinemia exacerbates inflammation and increases the oxidative stress along with regulating the levels of norepinephrine in the brain sympathetic system. Increased inflammatory cytokines have also been shown to disrupt neurotransmitter metabolism and synaptic plasticity which play a role in the development of depression via inhibiting serotonin. dopamine. melatonin, and glutamate signaling. An increased level of plasma insulin over time in the absence of exercising causes accumulation of lipid droplets in hepatocytes and striated muscles thus preventing the movement of glucose transporters shown to result in an increase in insulin resistance due to obesity and further culminates into depression. Further hyperinsulinemia-hyperglycemia condition arising due to exogenous insulin supplementation for diabetes management may also lead to physiological hyperinsulinemia associated depression. Triple therapy with SSRI, bupropion, and cognitive behavioral therapy aids in improving glycemic control. lowering fasting blood glucose, decreasing the chances of relapse. as well as decreasing cortisol levels to improve cognition and the underlying depression. Restoring the gut microbiota has also been shown to restore insulin sensitivity and reduce anxiety and depression symptoms in patients.
C1 [Sarwar, Haider; Rafiqi, Shafiya Imtiaz; Jinna, Sruthi; Khan, Sawleha Arshi; Karim, Tamanna; Qureshi, Omar; Zahid, Zeeshan A.; Jaume, Juan C.; Imam, Shahnawaz] Univ Toledo, Coll Med & Life Sci, Dept Med, Div Endocrinol, Toledo, OH 43614 USA.
   [Sarwar, Haider; Rafiqi, Shafiya Imtiaz; Khan, Sawleha Arshi; Karim, Tamanna; Qureshi, Omar; Zahid, Zeeshan A.; Jaume, Juan C.; Imam, Shahnawaz] Univ Toledo, Ctr Diabet & Endocrine Res, Toledo, OH 43614 USA.
   [Sarwar, Haider] Windsor Univ, Sch Med, Cayon, West Indies, St Kitts & Nevi.
   [Ahmad, Showkat] Bon Secours Mercy Hlth, Toledo, OH USA.
   [Khan, Sawleha Arshi] Mercy Hlth St Vincent Med Ctr, Toledo, OH USA.
   [Qureshi, Omar] Amer Univ, Caribbean Sch Med, Sint Maarten, Netherlands.
   [Elhai, Jon D.; Levine, Jason C.] Univ Toledo, Dept Psychol & Psychiat, Toledo, OH 43614 USA.
   [Naqvi, Shazia J.] Zepf Ctr, Toledo, OH USA.
C3 University System of Ohio; University of Toledo; University System of
   Ohio; University of Toledo; University System of Ohio; University of
   Toledo
RP Jaume, JC (corresponding author), Univ Toledo, Coll Med & Life Sci, 3000 Arlington Ave,MS 1186, Toledo, OH 43614 USA.
EM Juan.Jaume@utoledo.edu
RI Rafiqi, Shafiya Imtiaz/HZJ-7421-2023; Elhai, Jon/U-1901-2017; Imam,
   Shahanwaz/V-8132-2019
OI Imam, Shahnawaz/0000-0003-4700-5370; Elhai, Jon/0000-0001-5205-9010
FU University of Toledo, College of Medicine and Life Sciences grants
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: This work
   was funded in part by University of Toledo, College of Medicine and Life
   Sciences grants.
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NR 67
TC 18
Z9 18
U1 1
U2 15
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1179-5514
J9 CLIN MED INSIGHTS-EN
JI Clin. Med. Insights-Endocrinol. Diabetes
PD APR
PY 2022
VL 15
DI 10.1177/11795514221090244
PG 6
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA 0S7NV
UT WOS:000786458600001
PM 35494421
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Packham, J
   Tarar, B
AF Packham, Jonathan
   Tarar, Bilal
TI An overview of psoriatic arthritis including clinical manifestations,
   assessment, diagnostic criteria, investigations, drug management and
   GRAPPA guidelines
SO MUSCULOSKELETAL CARE
LA English
DT Article
DE assessment; diagnosis; psoriatic arthritis; treatment
ID NONSTEROIDAL ANTIINFLAMMATORY DRUGS; INFLAMMATORY BACK-PAIN;
   ANKYLOSING-SPONDYLITIS; DISEASE-ACTIVITY; DOUBLE-BLIND; AXIAL
   SPONDYLOARTHRITIS; AMERICAN-COLLEGE; MULTINATIONAL ASSESSMENT;
   CLASSIFICATION CRITERIA; EULAR RECOMMENDATIONS
AB Psoriatic arthritis (PsA) is a chronic and often progressive inflammatory disease, occurring in up to 30% of patients with psoriasis. Assessment of patients with PsA requires consideration of all disease domains, including peripheral arthritis, axial disease, enthesitis, dactylitis, skin psoriasis, psoriatic nail disease, uveitis and inflammatory bowel disease. Co-morbidities and related conditions should all be considered including: obesity, metabolic syndrome, cardiovascular disease, anxiety/depression, liver disease, chronic infections, malignancy, osteoporosis, fibromyalgia and reproductive health.
C1 [Packham, Jonathan; Tarar, Bilal] Midlands Partnership NHS Fdn Trust, Haywood Rheumatol Ctr, Stafford, Staffs, England.
   [Packham, Jonathan] Univ Nottingham, Acad Unit Populat & Lifespan Sci, Nottingham, England.
C3 University of Nottingham
RP Packham, J (corresponding author), Midlands Partnership NHS Fdn Trust, Haywood Rheumatol Ctr, Stafford, Staffs, England.
EM Jon.Packham@mpft.nhs.uk
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NR 95
TC 2
Z9 2
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1478-2189
EI 1557-0681
J9 MUSCULOSKELET CARE
JI Musculoskelet. Care
PD NOV
PY 2022
VL 20
SU 1
SI SI
BP S2
EP S11
DI 10.1002/msc.1693
PG 10
WC Rheumatology
WE Emerging Sources Citation Index (ESCI)
SC Rheumatology
GA 6A7WF
UT WOS:000880860400004
PM 36356108
OA Bronze
DA 2025-06-11
ER

PT J
AU Heidari, H
   Bagherniya, M
   Majeed, M
   Sathyapalan, T
   Jamialahmadi, T
   Sahebkar, A
AF Heidari, Hajar
   Bagherniya, Mohammad
   Majeed, Muhammed
   Sathyapalan, Thozhukat
   Jamialahmadi, Tannaz
   Sahebkar, Amirhossein
TI Curcumin-piperine co-supplementation and human health: A comprehensive
   review of preclinical and clinical studies
SO PHYTOTHERAPY RESEARCH
LA English
DT Review
DE clinical; curcumin; health; piperine; preclinical
ID CHRONIC PULMONARY COMPLICATIONS; TYPE-2 DIABETES-MELLITUS; METABOLIC
   SYNDROME; ADJUNCTIVE THERAPY; OXIDATIVE STRESS; SULFUR MUSTARD; BLACK
   PEPPER; D-GALACTOSE; IN-VITRO; COMBINATION
AB Curcumin is extracted from the rhizomes Curcuma longa L. It is known for its anti-inflammatory and anti-oxidant activities. Despite its safety and potential for use against various diseases, curcumin's utility is restricted due to its low oral bioavailability. Co-administration of curcumin along with piperine could potentially improve the bioavailability of curcumin. The present review aimed to provide an overview of the efficacy and safety of curcumin-piperine co-supplementation in human health. The findings of this comprehensive review show the beneficial effects of curcumin-piperine in improving glycemic indices, lipid profile and antioxidant status in diabetes, improving the inflammatory status caused by obesity and metabolic syndrome, reducing oxidative stress and depression in chronic stress and neurological disorders, also improving chronic respiratory diseases, asthma and COVID-19. Further high-quality clinical trial studies are needed to firmly establish the clinical efficacy of the curcumin-piperine supplement.
C1 [Heidari, Hajar] Isfahan Univ Med Sci, Food Secur Res Ctr, Sch Nutr & Food Sci, Dept Clin Nutr, Esfahan, Iran.
   [Bagherniya, Mohammad] Isfahan Univ Med Sci, Food Secur Res Ctr, Esfahan, Iran.
   [Majeed, Muhammed] Sabinsa Corp, East Windsor, NJ USA.
   [Sathyapalan, Thozhukat] Univ Hull, Hull York Med Sch, Acad Diabet Endocrinol & Metab, Kingston Upon Hull, England.
   [Jamialahmadi, Tannaz] Mashhad Univ Med Sci, Surg Oncol Res Ctr, Mashhad, Iran.
   [Jamialahmadi, Tannaz; Sahebkar, Amirhossein] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Biotechnol Res Ctr, Mashhad, Iran.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Appl Biomed Res Ctr, Mashhad, Iran.
   [Sahebkar, Amirhossein] Univ Western Australia, Sch Med, Perth, WA, Australia.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Sch Pharm, Dept Biotechnol, Mashhad, Iran.
C3 Isfahan University of Medical Sciences; Isfahan University of Medical
   Sciences; University of York - UK; University of Hull; Mashhad
   University of Medical Sciences; Mashhad University of Medical Sciences;
   Mashhad University of Medical Sciences; University of Western Australia;
   Mashhad University of Medical Sciences
RP Bagherniya, M (corresponding author), Isfahan Univ Med Sci, Food Secur Res Ctr, Esfahan, Iran.; Sahebkar, A (corresponding author), Mashhad Univ Med Sci, Pharmaceut Technol Inst, Biotechnol Res Ctr, Mashhad, Iran.
EM bagherniya@nutr.mui.ac.ir; amir_saheb2000@yahoo.com
RI Sathyapalan, Thozhukat/J-5212-2012; Sahebkar, Amirhossein/B-5124-2018
OI Sathyapalan, Thozhukat/0000-0003-3544-2231; Bagherniya,
   Mohammad/0000-0002-5861-6129
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NR 132
TC 78
Z9 80
U1 17
U2 81
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0951-418X
EI 1099-1573
J9 PHYTOTHER RES
JI Phytother. Res.
PD APR
PY 2023
VL 37
IS 4
BP 1462
EP 1487
DI 10.1002/ptr.7737
EA JAN 2023
PG 26
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA D5KZ9
UT WOS:000922500500001
PM 36720711
OA Green Accepted
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Magnotti, M
   Futterwelt, W
AF Magnotti, Michael
   Futterwelt, Walter
TI Obesity and the polycystic ovary syndrome
SO MEDICAL CLINICS OF NORTH AMERICA
LA English
DT Article
ID IMPAIRED GLUCOSE-TOLERANCE; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   ACANTHOSIS NIGRICANS; OVULATION INDUCTION; CLOMIPHENE CITRATE;
   DIABETES-MELLITUS; MEDICAL PROGRESS; PREDICTIVE-VALUE; CAUCASIAN WOMEN
AB Polycystic ovarian syndrome (PCOS) is extremely common among reproductive-aged women, but often goes undiagnosed. PCOS is associated with the metabolic syndrome and carries a greatly increased risk of impaired glucose tolerance and type 2 diabetes mellitus, and cardiovascular risks. Treatment of PCOS may provide relief of cosmetic problems and depression by improving patient self-esteem. In addition, because of its association with the metabolic syndrome, type 2 diabetes mellitus, and cardiovascular disease, its recognition and treatment can potentially be life saving. This article reviews the impact, pathophysiology, and associated risks of obesity and the metabolic syndrome in PCOS.
C1 Mt Sinai Hosp, Mt Sinai Sch Med, New York, NY 10029 USA.
C3 Icahn School of Medicine at Mount Sinai
RP Futterwelt, W (corresponding author), Mt Sinai Hosp, Mt Sinai Sch Med, New York, NY 10029 USA.
EM wfutt@ix.netcom.com
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NR 80
TC 24
Z9 28
U1 1
U2 5
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0025-7125
EI 1557-9859
J9 MED CLIN N AM
JI Med. Clin. N. Am.
PD NOV
PY 2007
VL 91
IS 6
BP 1151
EP +
DI 10.1016/j.mcna.2007.06.010
PG 20
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 235HO
UT WOS:000251224600010
PM 17964914
DA 2025-06-11
ER

PT J
AU Sahebkar, A
AF Sahebkar, Amirhossein
TI Why it is necessary to translate curcumin into clinical practice for the
   prevention and treatment of metabolic syndrome?
SO BIOFACTORS
LA English
DT Review
DE curcumin; Curcuma longa L; phytochemical; syndrome X; insulin resistance
ID HEPATIC STELLATE CELLS; TUMOR-NECROSIS-FACTOR; SERUM URIC-ACID;
   CORONARY-HEART-DISEASE; NITRIC-OXIDE SYNTHASE; 3RD NATIONAL-HEALTH;
   OXIDATIVE STRESS; IN-VITRO; TNF-ALPHA; CARDIOVASCULAR-DISEASE
AB Curcumin (diferuloylmethane) is the yellow-orange pigment of dried Curcuma longa L. rhizomes (turmeric). During the past two decades, there has been a large volume of published studies describing the biological and pharmacological properties of this phytochemical including anticancer, anti-inflammatory, antioxidant, antithrombotic, antiatherosclerotic, cardioprotective, neuroprotective, memory enhancing, antiparkinsonism, antirheumatic, anti-infectious, antiaging, antipsoriatic, and anticonvulsant activities. In addition, curcumin has been shown to be extremely safe and interact with multiple molecular targets that are involved in the pathogenesis of metabolic syndrome. Curcumin could favorably affect all leading components of metabolic syndrome including insulin resistance, obesity, hypertriglyceridemia, decreased HDL-C and hypertension, and prevent the deleterious complications of MetS including diabetes and cardiovascular disease. Owing to its antioxidant and anti-inflammatory properties, curcumin can also exert several pleiotropic effects and improve endothelial dysfunction, adipokine imbalances, and hyperuricemia which usually accompany MetS. Despite the potential tremendous benefit of this multifaceted phytopharmaceutical, no trial result has yet been publicized on this issue. This review seeks to briefly summarize the ample scientific evidence that supports the therapeutic efficacy of curcumin, at least as an adjunctive treatment, in patients with MetS. (c) 2012 BioFactors, 2013
C1 [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Cardiovasc Res Ctr, Mashhad 917751365, Iran.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Biotechnol Res Ctr, Mashhad 917751365, Iran.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Sch Pharm, Mashhad 917751365, Iran.
C3 Mashhad University of Medical Sciences; Mashhad University of Medical
   Sciences; Mashhad University of Medical Sciences
RP Sahebkar, A (corresponding author), Mashhad Univ Med Sci, Biotechnol Res Ctr, Mashhad 917751365, Iran.
EM sahebkarah811@mums.ac.ir
RI Sahebkar, Amirhossein/B-5124-2018
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NR 181
TC 139
Z9 143
U1 0
U2 52
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0951-6433
EI 1872-8081
J9 BIOFACTORS
JI Biofactors
PD MAR-APR
PY 2013
VL 39
IS 2
BP 197
EP 208
DI 10.1002/biof.1062
PG 12
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 129TF
UT WOS:000317864700005
PM 23239418
DA 2025-06-11
ER

PT J
AU Pietrabissa, G
   Cammisuli, DM
   Scarpina, F
   Volpi, C
   Crotti, L
   Mauro, A
   Gondoni, LA
   Castelnuovo, G
AF Pietrabissa, Giada
   Cammisuli, Davide Maria
   Scarpina, Federica
   Volpi, Clarissa
   Crotti, Lia
   Mauro, Alessandro
   Gondoni, Luca Alessandro
   Castelnuovo, Gianluca
TI Executive Attentional Dyscontrol as a Core Cognitive and Behavioral
   Feature of Individuals with Obesity and Cardiovascular Disease: A
   Cross-Sectional Investigation
SO BRAIN SCIENCES
LA English
DT Article
DE cardiovascular disease; cardiac rehabilitation; obesity; attentional
   deficit; impulsiveness; anxiety; depression; quality of life
ID MINI-MENTAL-STATE; BODY-MASS INDEX; HEART-FAILURE; OLDER-ADULTS;
   METABOLIC SYNDROME; HOSPITAL ANXIETY; IMPAIRMENT; IMPULSIVITY;
   PREVALENCE; RISK
AB Executive attention as a frontal domain ability that is effective in potentially blocking distracting information, reconciling conflicts among simultaneous attentional demands, and regulating impulsive behavior may be impaired in individuals with obesity and cardiovascular disease (CVD). This study aimed (i) to explore the presence of selected cognitive (global cognitive impairment, sensitivity to interference, and attention) and psychological (quality of life, depression, anxiety, and impulsivity) dimensions and (ii) to examine the interactive relationship between attentional dyscontrol-both as a psychological and as a cognitive measure-and the above-mentioned variables in a sample of patients with CVD attending a cardiac rehabilitation program across different body mass index (BMI) levels. Clinical information of 104 patients with CVD was retrospectively collected. Participants were classified into three groups according to their BMI as follows: normal weight (NW = 30), overweight (OW = 19), and obese (OB = 55). Individuals with CVD and a higher BMI showed problems in controlling executive attention-through both neuropsychological and behavioral measures. Specifically, OB patients demonstrated reduced sensitivity to cognitive interference, lower capabilities in divided attention during visual-tracking tasks, and greater impulsivity compared to NW patients. This behavioral characteristic was also found to be correlated with higher levels of anxiety and depression and a lower quality of life. Implications for cognitive rehabilitation were discussed to offer directions for better management of patients with CVD and obesity.
C1 [Pietrabissa, Giada; Cammisuli, Davide Maria; Castelnuovo, Gianluca] Catholic Univ Milan, Dept Psychol, I-20123 Milan, Italy.
   [Pietrabissa, Giada; Castelnuovo, Gianluca] IRCCS Ist Auxol Italiano, Clin Psychol Res Lab, I-20149 Milan, Italy.
   [Scarpina, Federica; Mauro, Alessandro] IRCCS Ist Auxol Italiano, San Giuseppe Hosp, Neurol & Neurorehabil Dept, I-28824 Oggebbio, Vco, Italy.
   [Scarpina, Federica; Mauro, Alessandro] Univ Turin, Dept Neurosci Rita Levi Montalicini, I-10126 Turin, Italy.
   [Volpi, Clarissa; Crotti, Lia] IRCCS Ist Auxol Italiano, San Luca Hosp, Cardiac Rehabil Dept, I-20149 Milan, Italy.
   [Crotti, Lia] Milano Bicocca Univ, Dept Med & Surg, I-20126 Milan, Italy.
   [Gondoni, Luca Alessandro] IRCCS Ist Auxol Italiano, San Giuseppe Hosp, Cardiac Rehabil Dept, I-28824 Oggebbio, Vco, Italy.
C3 Catholic University of the Sacred Heart; IRCCS Istituto Auxologico
   Italiano; IRCCS Istituto Auxologico Italiano; University of Turin; IRCCS
   Istituto Auxologico Italiano; University of Milano-Bicocca; IRCCS
   Istituto Auxologico Italiano
RP Cammisuli, DM (corresponding author), Catholic Univ Milan, Dept Psychol, I-20123 Milan, Italy.
EM giada.pietrabissa@unicatt.it; davide.cammisuli1@unicatt.it;
   f.scarpina@auxologico.it; c.volpi@auxologico.it; l.crotti@auxologico.it;
   mauro@auxologico.it; l.gondoni@auxologico.it;
   gianluca.castelnuovo@unicatt.it
RI Milesi, Alessandra/KRQ-4573-2024; Scarpina, Federica/AAB-6335-2019;
   crotti, lia/AAB-3914-2019; Pietrabissa, Giada/AAA-2056-2019;
   Castelnuovo, Gianluca/AAC-1780-2019
OI crotti, lia/0000-0001-8739-6527; Scarpina, Federica/0000-0003-4326-1596;
   Pietrabissa, Giada/0000-0002-5911-5748; Castelnuovo,
   Gianluca/0000-0003-2633-9822
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NR 82
TC 2
Z9 2
U1 1
U2 4
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3425
J9 BRAIN SCI
JI Brain Sci.
PD AUG
PY 2023
VL 13
IS 8
AR 1182
DI 10.3390/brainsci13081182
PG 13
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA Q4IJ0
UT WOS:001057167200001
PM 37626538
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Bomboy, KT
   Graber, JS
   Wallis, EP
AF Bomboy, Kristen T.
   Graber, Jennifer S.
   Wallis, Eric P.
TI Improved Prescriber Adherence to Guidelines on Antipsychotic Medication
   Management Through Increased Access to Metabolic Monitoring Forms
SO JOURNAL OF THE AMERICAN PSYCHIATRIC NURSES ASSOCIATION
LA English
DT Article
DE community mental health centers; mental disorders; antipsychotic agents;
   drug-related side effects and adverse reactions
ID SEVERE MENTAL-ILLNESS; PEOPLE; METAANALYSIS; RISK
AB INTRODUCTION: Patients diagnosed with a chronic mental illness have a 2 to 3 times higher likelihood of developing metabolic abnormalities than their non-mentally ill counterparts due to prescription medication use. Metabolic syndrome has been reported in 52% of patients prescribed atypical antipsychotic medications, compared to the general population rate of 23%, and has been found to place individuals at high risk of death from diabetes and cardiovascular disease. OBJECTIVE: This quality improvement project aimed to increase the rate of metabolic monitoring and related lab orders for patients prescribed atypical antipsychotic medications in a rural community mental health center to improve patient outcomes. METHOD: The use of a metabolic monitoring tool was implemented onsite. Chart audits were used to assess the effectiveness of introducing a metabolic monitoring form at a rural community mental health center and explore the feasibility of implementing a metabolic monitoring tool organization-wide. RESULTS: Metabolic lab orders increased from 1 to 59 at 8 weeks postimplementation for Clinic A after the implementation of a metabolic monitoring tool. CONCLUSION: Prescriber lab order rates improved using a metabolic monitoring form. Adherence to guideline-based care will improve patient outcomes by detecting the onset of metabolic syndrome earlier in the disease course. Early monitoring for metabolic changes will improve the health of patients diagnosed with a mental illness.
C1 [Bomboy, Kristen T.] Lighthouse Behav Wellness Ctr, Ardmore, OK USA.
   [Bomboy, Kristen T.] Maryville Univ, St Louis, MO USA.
   [Bomboy, Kristen T.; Graber, Jennifer S.] Univ Delaware, Newark, DE USA.
   [Wallis, Eric P.] Coordinated Care Hlth Solut Lab, Oklahoma City, OK USA.
C3 Maryville University Saint Louis; University of Delaware
RP Bomboy, KT (corresponding author), 2010 Boren Blvd, Seminole, OK 74868 USA.
EM kbomboy@maryville.edu
OI Bomboy, Kristen/0000-0002-0852-2618
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NR 27
TC 6
Z9 6
U1 0
U2 2
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1078-3903
EI 1532-5725
J9 J AM PSYCHIAT NURSES
JI J. Am. Psych. Nurses Assoc.
PD MAR
PY 2021
VL 27
IS 2
BP 162
EP 168
AR 1078390320906196
DI 10.1177/1078390320906196
EA FEB 2020
PG 7
WC Nursing; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Psychiatry
GA RA6SM
UT WOS:000513385600001
PM 32054390
DA 2025-06-11
ER

PT J
AU Namikoshi, T
   Satoh, M
   Tomita, N
   Haruna, Y
   Kobayashi, S
   Kornai, N
   Sasaki, T
   Kashihara, N
AF Namikoshi, Tamehachi
   Satoh, Minoru
   Tomita, Naruya
   Haruna, Yoshisuke
   Kobayashi, Shinya
   Kornai, Norio
   Sasaki, Tainaki
   Kashihara, Naoki
TI Pioglitazone ameliorates endothelial dysfunction in obese rats with
   nephropathy
SO BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
LA English
DT Article
DE endothelium; oxidative stress; renal injury; endothelial dysfunction;
   nitrative stress; nephropathy; obesity; thiazolidinediones
ID METABOLIC SYNDROME; INSULIN SENSITIVITY; OXIDATIVE STRESS; RENAL INJURY;
   KIDNEY; INFLAMMATION; ADIPONECTIN; INHIBITION; MORTALITY; LIGANDS
AB Endothelial dysfunction is a key event in the development of renovascular complications in the metabolic syndrome. The aim of this study was to elucidate the pathogenetic mechanisms involved in renovascular injuries in the Zucker obese rat, a model of the metabolic syndrome, and to examine the therapeutic effects of pioglitazone, a thiazolidinedione. Obese rats fed high-protein diet (OHP) for 12 weeks exhibited nephropathy and endothelial dysfunction, which were improved by pioglitazone. Accumulation of nitrotyrosine, a tracer of nitrative stress, was increased in aorta of the OHP group. The mRNA expressions of NADPH oxidase components and inducible nitric oxide synthase in the aorta were enhanced in the OHP group. Pioglitazone reduced nitrotyrosine in the aorta of the OHP group, inhibiting the augmented expression levels of both. These results suggest that nitrative stress could cause endothelial dysfunction in the rat model of metabolic syndrome with nephropathy, and that pioglitazone ameliorates these injuries, presumably by reducing nitrative stress. (C) 2007 Elsevier Inc. All rights reserved.
C1 Kawasaki Med Sch, Dept Internal Med, Div Nephrol, Kurashiki, Okayama 7010192, Japan.
C3 Kawasaki Medical School
RP Satoh, M (corresponding author), Kawasaki Med Sch, Dept Internal Med, Div Nephrol, 577 Matsushima, Kurashiki, Okayama 7010192, Japan.
EM msatoh@med.kawasaki-m.ac.jp
RI Satoh, Minoru/E-2421-2011
CR ALAVI FK, 1995, CLIN NEPHROL, V43, P122
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NR 27
TC 12
Z9 15
U1 0
U2 2
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0006-291X
EI 1090-2104
J9 BIOCHEM BIOPH RES CO
JI Biochem. Biophys. Res. Commun.
PD OCT 5
PY 2007
VL 361
IS 4
BP 835
EP 840
DI 10.1016/j.bbrc.2007.07.136
PG 6
WC Biochemistry & Molecular Biology; Biophysics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics
GA 206KE
UT WOS:000249181500004
PM 17681282
DA 2025-06-11
ER

PT J
AU Vergoossen, LWM
   Jansen, JFA
   Backes, WH
   Schram, MT
AF Vergoossen, Laura W. M.
   Jansen, Jacobus F. A.
   Backes, Walter H.
   Schram, Miranda T.
TI Cardiometabolic determinants of early and advanced brain alterations:
   Insights from conventional and novel MRI techniques
SO NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
LA English
DT Review
DE Cardiometabolic risk factors; magnetic resonance imaging; brain disease
ID WHITE-MATTER HYPERINTENSITIES; SMALL VESSEL DISEASE; TYPE-2
   DIABETES-MELLITUS; VASCULAR RISK-FACTORS; CEREBRAL-BLOOD-FLOW;
   SUBCLINICAL CEREBROVASCULAR-DISEASE; MEASURED PHYSICAL-ACTIVITY;
   VISCERAL FAT ACCUMULATION; BODY-MASS INDEX; COGNITIVE IMPAIRMENT
AB Cardiometabolic risk factors may be of key importance in the development of future brain diseases like dementia or depression. However, it remains unclear how these risk factors exactly affect the brain. Advanced MR imaging methods such as, diffusion weighted and functional MRI, can provide detailed insights into subtle brain changes, and potentially into early development of disease. In this narrative review, we summarize the available evidence on the associations of cardiometabolic risk factors with subtle changes in brain MRI measures. We found clear evidence that hyperglycemia, physical inactivity, central obesity, and hypertension are associated with both structural and functional brain alterations, while the role of dyslipidemia is far less clear. However, longitudinal evidence that assesses temporality of the associations with more advanced and thus more precise brain imaging methods is needed to improve our insights into the complex etiology of brain diseases.
C1 [Vergoossen, Laura W. M.; Jansen, Jacobus F. A.; Backes, Walter H.] Maastricht Univ, Med Ctr, Dept Radiol & Nucl Med, Maastricht, Netherlands.
   [Vergoossen, Laura W. M.; Jansen, Jacobus F. A.; Backes, Walter H.; Schram, Miranda T.] Maastricht Univ, Sch Mental Hlth & Neurosci MHeNs, Maastricht, Netherlands.
   [Schram, Miranda T.] Maastricht Univ, Dept Med, Maastricht, Netherlands.
   [Vergoossen, Laura W. M.; Schram, Miranda T.] Maastricht Univ, Sch Cardiovasc Dis CARIM, Maastricht, Netherlands.
   [Schram, Miranda T.] Maastricht Univ, Med Ctr, Heart & Vasc Cent, Maastricht, Netherlands.
   [Jansen, Jacobus F. A.] Univ Technol Eindhoven, Dept Elect Engn, Eindhoven, Netherlands.
C3 Maastricht University; Maastricht University; Maastricht University;
   Maastricht University; Maastricht University; Eindhoven University of
   Technology
RP Schram, MT (corresponding author), Maastricht Univ, Sch Mental Hlth & Neurosci MHeNs, Maastricht, Netherlands.
EM m.schram@maastrichtuniversity.nl
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NR 182
TC 9
Z9 9
U1 0
U2 8
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0149-7634
EI 1873-7528
J9 NEUROSCI BIOBEHAV R
JI Neurosci. Biobehav. Rev.
PD AUG
PY 2020
VL 115
BP 308
EP 320
DI 10.1016/j.neubiorev.2020.04.001
PG 13
WC Behavioral Sciences; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Behavioral Sciences; Neurosciences & Neurology
GA OD3DJ
UT WOS:000579731200025
PM 32439370
OA hybrid
DA 2025-06-11
ER

PT J
AU Li, Y
   Yuan, HX
   Li, QQ
   Geng, SS
   Chen, X
   Zhu, YQ
   Jiang, H
AF Li, Yang
   Yuan, Huixiao
   Li, Qingqing
   Geng, Shasha
   Chen, Xin
   Zhu, Yingqian
   Jiang, Hua
TI Lifestyle-based oxidative balance score and its association with
   cardiometabolic health of the community-dwelling elderly: A
   cross-sectional secondary analysis
SO FRONTIERS IN CARDIOVASCULAR MEDICINE
LA English
DT Article
DE healthy lifestyle; oxidative stress; cardiometabolic risk factors;
   community-dwelling elderly; general practice
ID INSULIN-RESISTANCE; BLOOD-PRESSURE; STRESS; AGE; OBESITY; HYPERTENSION;
   BIOMARKERS; PREDICTOR; INCIDENT; RISK
AB BackgroundCardiometabolic diseases, the main disease burden in older adults, are largely caused by oxidative stress resulting from lifestyle factors. This study investigated the relationship between lifestyle-based oxidative balance scores and cardiometabolic health among the community-dwelling elderly. MethodsThis work conducted a secondary analysis of previous cross-sectional research data and constructed a lifestyle-based oxidative balance score (LOBS) including 4 components (higher scores were considered more antioxidant). Linear regression models and logistic regression models were used to evaluate the associations with cardiometabolic biomarkers and the number of cardiometabolic risk factors. Besides, we investigated whether these associations differed by covariates. ResultsA total of 710 individuals (60.99% female, median age 70.0 years) were recruited. The inverse associations of LOBS with SBP and TG and the positive association with HDLC were statistically significant in both linear and logistic regression models. In contrast, an inverse association of LOBS with DBP was significant only in the linear regression model (all P < 0.05). The associations of LOBS with TG and HDLC were not affected by age, gender, or socioeconomic level. A significant inverse association was observed between LOBS and the number of cardiometabolic risk factors. Compared with the lowest LOBS, the ORs for more cardiometabolic risk factors in the second and third intervals were 0.577 (0.422, 0.788) and 0.460 (0.301, 0.703) (both P < 0.001). ConclusionIn summary, this study shows that antioxidant-predominant lifestyle exposure yields a better cardiometabolic health status. We recommend that general practitioners should offer comprehensive healthy lifestyle management to community-dwelling elderly.
C1 [Li, Yang; Yuan, Huixiao; Li, Qingqing; Geng, Shasha; Chen, Xin; Zhu, Yingqian; Jiang, Hua] Tongji Univ, Sch Med, Shanghai East Hosp, Dept Gen Practice, Shanghai, Peoples R China.
   [Li, Yang; Yuan, Huixiao; Li, Qingqing; Geng, Shasha; Chen, Xin; Zhu, Yingqian; Jiang, Hua] Tongji Univ, Shanghai East Hosp, Sch Med, Dept Geriatr, Shanghai, Peoples R China.
C3 Tongji University; Tongji University
RP Jiang, H (corresponding author), Tongji Univ, Sch Med, Shanghai East Hosp, Dept Gen Practice, Shanghai, Peoples R China.; Jiang, H (corresponding author), Tongji Univ, Shanghai East Hosp, Sch Med, Dept Geriatr, Shanghai, Peoples R China.
EM huajiang2013@tongji.edu.cn
RI Li, Yang/AHD-6076-2022
OI Li, Yang/0000-0002-0088-1544
CR Al-Aubaidy HA, 2014, REDOX REP, V19, P87, DOI 10.1179/1351000213Y.0000000080
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NR 38
TC 12
Z9 12
U1 0
U2 7
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2297-055X
J9 FRONT CARDIOVASC MED
JI Front. Cardiovasc. Med.
PD SEP 27
PY 2022
VL 9
AR 1000546
DI 10.3389/fcvm.2022.1000546
PG 15
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 5P1ZS
UT WOS:000872957900001
PM 36237896
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Colognesi, M
   Gabbia, D
   De Martin, S
AF Colognesi, Martina
   Gabbia, Daniela
   De Martin, Sara
TI Depression and Cognitive Impairment-Extrahepatic Manifestations of NAFLD
   and NASH
SO BIOMEDICINES
LA English
DT Review
DE non-alcoholic fatty liver disease; NAFLD; steatohepatitis; NASH;
   cognitive impairment; memory dysfunction; Alzheimer's disease;
   neurodegeneration
ID FATTY LIVER-DISEASE; BRAIN INSULIN-RESISTANCE; OBSTRUCTIVE SLEEP-APNEA;
   INTRANASAL INSULIN; METABOLIC SYNDROME; IMPROVES MEMORY; OLDER-ADULTS;
   NEURODEGENERATION; ANXIETY; ASSOCIATION
AB Non-alcoholic fatty liver disease (NAFLD) and its complication non-alcoholic steatohepatitis (NASH) are important causes of liver disease worldwide. Recently, a significant association between these hepatic diseases and different central nervous system (CNS) disorders has been observed in an increasing number of patients. NAFLD-related CNS dysfunctions include cognitive impairment, hippocampal-dependent memory impairment, and mood imbalances (in particular, depression and anxiety). This review aims at summarizing the main correlations observed between NAFLD development and these CNS dysfunctions, focusing on the studies investigating the mechanism(s) involved in this association. Growing evidences point at cerebrovascular alteration, neuroinflammation, and brain insulin resistance as NAFLD/NASH-related CNS manifestations. Since the pharmacological options available for the management of these conditions are still limited, further studies are needed to unravel the mechanism(s) of NAFLD/NASH and their central manifestations and identify effective pharmacological targets.
C1 [Colognesi, Martina; Gabbia, Daniela; De Martin, Sara] Univ Padua, Dept Pharmaceut & Pharmacol Sci, Lgo Meneghetti 2, I-35131 Padua, Italy.
C3 University of Padua
RP De Martin, S (corresponding author), Univ Padua, Dept Pharmaceut & Pharmacol Sci, Lgo Meneghetti 2, I-35131 Padua, Italy.
EM martina.colognesi@studenti.unipd.it; daniela.gabbia@unipd.it;
   sara.demartin@unipd.it
RI De Martin, Sara/AAC-7396-2022; Gabbia, Daniela/J-9984-2019; Colognesi,
   Martina/ABA-1265-2020
OI Colognesi, Martina/0009-0000-7839-7851; DE MARTIN,
   SARA/0000-0001-6398-8237; GABBIA, DANIELA/0000-0003-2247-8227
FU University of Padova [DEMA_SID19_01]
FX This research received no external funding. D.G. post-doctoral
   fellowship was supported by the University of Padova (DEMA_SID19_01).
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   Younossi ZM, 2019, J HEPATOL, V70, P531, DOI 10.1016/j.jhep.2018.10.033
   Youssef NA, 2013, LIVER INT, V33, P1062, DOI 10.1111/liv.12165
NR 81
TC 63
Z9 67
U1 4
U2 17
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2227-9059
J9 BIOMEDICINES
JI Biomedicines
PD JUL
PY 2020
VL 8
IS 7
AR 229
DI 10.3390/biomedicines8070229
PG 16
WC Biochemistry & Molecular Biology; Medicine, Research & Experimental;
   Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Research & Experimental Medicine;
   Pharmacology & Pharmacy
GA MS3LO
UT WOS:000554182300001
PM 32708059
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Williams, D
AF Williams, D
TI Pregnancy: a stress test for life
SO CURRENT OPINION IN OBSTETRICS & GYNECOLOGY
LA English
DT Article
DE pre-eclampsia; metabolic syndrome; hypertension; gestational; diabetes
   mellitus; ischaemic heart disease
ID INSULIN-RESISTANCE; ENDOTHELIAL DYSFUNCTION; HYPERTENSIVE DISORDERS;
   FOLLOW-UP; PREECLAMPSIA; WOMEN; RISK; COMPLICATIONS; ASSOCIATION;
   CHOLESTASIS
AB Purpose of review
   This review describes how the physiological demands of pregnancy act as a maternal stress test that can predict a woman's health in later life. Pregnancy transiently catapults a woman into a metabolic syndrome that predisposes to vascular endothelial dysfunction. Women who are already predisposed to this phenotype develop gestational hypertension or diabetes mellitus, which re-emerge in later life as the metabolic syndrome returns. Pregnancy can also temporarily unmask sub-clinical disease, which may return in later life when the effects of ageing diminish the limited reserves of a vulnerable organ.
   Recent findings
   Recent studies have attempted to assess how gestational syndromes affect the risk for a woman of developing a diverse range of diseases in later life. As well as cardiovascular disease and diabetes mellitus, pregnancy can reveal a vulnerability to thyroid and pituitary disorders, liver and renal disease, depression, thrombosis and even cancer.
   Summary
   Although our knowledge of this phenomenon is incomplete, women who have had gestational syndromes, in particular pregnancy-induced hypertension/preeclampsia or gestational diabetes, should make lifestyle changes that will reduce their risk of cardiovascular disease in later life.
C1 Univ London Imperial Coll Sci Technol & Med, Chelsea & Westminster Hosp, Acad Dept Obstet & Gynaecol, London SW10 9NH, England.
C3 Imperial College London
RP Univ London Imperial Coll Sci Technol & Med, Chelsea & Westminster Hosp, Acad Dept Obstet & Gynaecol, 369 Fulham Rd, London SW10 9NH, England.
EM david.williams@imperial.ac.uk
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NR 56
TC 260
Z9 286
U1 1
U2 13
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1040-872X
EI 1473-656X
J9 CURR OPIN OBSTET GYN
JI Curr. Opin. Obstet. Gynecol.
PD DEC
PY 2003
VL 15
IS 6
BP 465
EP 471
DI 10.1097/00001703-200312000-00002
PG 7
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA 803HG
UT WOS:000220221600002
PM 14624211
DA 2025-06-11
ER

PT J
AU Sánchez-Martínez, V
   Romero-Rubio, D
   Abad-Pérez, MJ
   Descalzo-Cabades, MA
   Alonso-Gutiérrez, S
   Salazar-Fraile, J
   Montagud, V
   Fácila, L
AF Sanchez-Martinez, Vanessa
   Romero-Rubio, Dolores
   Jose Abad-Perez, Maria
   Amparo Descalzo-Cabades, Maria
   Alonso-Gutierrez, Sofia
   Salazar-Fraile, Jose
   Montagud, Vicente
   Facila, Lorenzo
TI Metabolic Syndrome and Cardiovascular Risk in People Treated with
   Long-Acting Injectable Antipsychotics
SO ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS
LA English
DT Article
DE Metabolic syndrome; cardiovascular risk; severe mental disorders;
   long-acting injectable antipsychotics; outpatients; gender differences
ID SCHIZOPHRENIA-PATIENTS; ORAL ANTIPSYCHOTICS; MENTAL-ILLNESS; MORTALITY;
   PREVALENCE; ASSOCIATION; POPULATION; MECHANISMS; FRAMINGHAM; DISORDERS
AB Background: People with schizophrenia and other severe mental disorders have an increased mortality mainly attributed to natural causes, specifically cardiovascular disease and cancer. The metabolic syndrome and the Framingham Risk Score are epidemiologic tools related to long-term cardiovascular disease risk and they are increased in people with severe mental disorders. This increase has been attributed both to the disorder itself and to the use of antipsychotic drugs.
   Objective: To quantify the cardiovascular risk in a group of people treated with long-acting injectable antipsychotics.
   Methods: This is a cross-sectional study developed in an outpatient mental health clime in which the prevalence of metabolic syndrome was estimated and the cardiovascular risk was measured using the Framingham Risk Score. All the analyses were separated by gender.
   Results: 130 people (81 men) were recruited. According to the International Diabetes Federation criteria, 60 participants (46,2%) had metabolic syndrome. The individual criterion most often met in both genders was obesity. The mean Framingham Risk Score for the sample was moderate, 7,7 (SD: 6,3). For women, the risk was lower (mean 5,7, SD: 4,9) than for men (mean=9, SD: 6,7). There were no significant differences in the prevalence of metabolic syndrome and Framingham Risk Scores by long-acting injectable antipsychotic or years of treatment.
   Conclusion: The prevalence of metabolic syndrome and the cardiovascular risk are high in people with psychosis treated with long acting injectable antipsychotics. To better address this vulnerability, the recommendations involve both behavioral and pharmacological interventions.
C1 [Sanchez-Martinez, Vanessa] Univ Valencia, Fac Nursing & Chiropody, Dept Nursing, C Jaume Roig S-N, Valencia 46010, Spain.
   [Romero-Rubio, Dolores; Jose Abad-Perez, Maria; Amparo Descalzo-Cabades, Maria; Alonso-Gutierrez, Sofia; Salazar-Fraile, Jose] Community Mental Hlth Ctr Pere Bonfill, Valencia, Spain.
   [Salazar-Fraile, Jose] Hosp Gen Univ Valencia, CIBERSAM, Valencia, Spain.
   [Montagud, Vicente; Facila, Lorenzo] Hosp Gen Univ Valencia, Cardiol Dept, Valencia, Spain.
C3 University of Valencia; CIBER - Centro de Investigacion Biomedica en
   Red; CIBERSAM
RP Sánchez-Martínez, V (corresponding author), Univ Valencia, Fac Nursing & Chiropody, Dept Nursing, C Jaume Roig S-N, Valencia 46010, Spain.
EM Vanessa.sanchez@uv.es
RI Facila, Lorenzo/B-5074-2012; Sánchez-Martínez, Vanessa/AAA-7169-2019
OI Facila Rubio, Lorenzo/0000-0003-1402-4364; Sanchez-Martinez,
   Vanessa/0000-0001-6097-7655
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NR 56
TC 21
Z9 22
U1 2
U2 12
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1871-5303
EI 2212-3873
J9 ENDOCR METAB IMMUNE
JI Endocr. Metab. Immune Disord.-Drug Targets
PY 2018
VL 18
IS 4
BP 379
EP 387
DI 10.2174/1871530317666171120151201
PG 9
WC Endocrinology & Metabolism; Immunology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Immunology; Pharmacology & Pharmacy
GA GJ5PP
UT WOS:000435434400013
PM 29165095
DA 2025-06-11
ER

PT J
AU Roriz-Cruz, M
   Rosset, I
   Wada, T
   Sakagami, T
   Ishine, M
   Roriz-Filho, JS
   Cruz, TRS
   Rodrigues, RP
   Resmini, I
   Sudoh, S
   Wakatsuki, Y
   Nakagawa, M
   Souza, AC
   Kita, T
   Matsubayashi, K
AF Roriz-Cruz, Matheus
   Rosset, Idiane
   Wada, Taizo
   Sakagami, Teiji
   Ishine, Masayuki
   Roriz-Filho, Jarbas S.
   Cruz, Thadeu R. S.
   Rodrigues, Rosalina P.
   Resmini, Isvania
   Sudoh, Shinji
   Wakatsuki, Yoshio
   Nakagawa, Masanori
   Souza, Antonio C.
   Kita, Toru
   Matsubayashi, Kozo
TI Stroke-independent association between metabolic syndrome and functional
   dependence, depression, and low quality of life in elderly
   community-dwelling Brazilian people
SO JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
LA English
DT Article
DE metabolic syndrome; functional dependence; depression; cognitive
   impairment; QoL
ID CARDIOVASCULAR RISK-FACTORS; INSULIN-RESISTANCE; COGNITIVE IMPAIRMENT;
   DIABETES-MELLITUS; OXIDATIVE STRESS; HIP RATIO; DISABILITY; DIAGNOSIS;
   DISEASE; DETERMINANTS
AB OBJECTIVES: Metabolic syndrome (Met.S) is a risk factor for stroke, dementia, and ischemic heart disease (IHD). It is unclear whether Met.S is an independent risk factor for functional dependence, depression, cognitive impairment, and low health-related quality of life (HRQoL) in a population free of clinical stroke.
   DESIGN: Cross-sectional.
   SETTING: Two communities in southern Brazil.
   PARTICIPANTS: Four hundred twenty people aged 60 and older.
   MEASUREMENTS: An adapted (body mass index >= 30 kg/m(2) and blood pressure >= 140/90) Adult Treatment Panel III definition was used in diagnosing Met.S. Depression (Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Revised) and Mini-Mental State Examination were evaluated along with activities of daily living (ADLs) and instrumental activities of daily living (IADLs). HRQoL was measured using a visual analogue scale (0-10). All values were adjusted for age, sex, and presence of IHD.
   RESULTS: Forty (9.5%) subjects had a stroke and were excluded from the final analysis. Met.S was present in 37.4% of the stroke-free population. Met.S was significantly and independently associated with 2.24 times as much ADL dependence, 2.39 times as much IADL dependence, a 2.12 times higher risk of depression, a 2.27 times higher likelihood of cognitive impairment, and a 1.62 times higher chance of low self-perceived HRQoL (all P < 0.05). Adjustment for its own components reduced the strength of the above associations but did not eliminate their statistical significance. If Met.S were removed from this population, dependence, depression, cognitive impairment, and low QoL would be reduced 15.0% to 21.4%.
   CONCLUSION: Met.S was significantly associated with functional dependence, depression, cognitive impairment, and low HRQoL, and its effects were independent of clinical stroke, IHD, and its own individual components.
C1 Kyoto Univ, Dept Neurol, Div Geriatr Psychiat, Kyoto, Japan.
   Kyoto Univ, Dept Geriatr Med, Div Geriatr Psychiat, Kyoto, Japan.
   Kyoto Univ, Dept Psychiat, Div Geriatr Psychiat, Kyoto, Japan.
   Kyoto Univ, Dept Cardiovasc Med, Kyoto, Japan.
   Kyoto Univ, Dept Field Med, Kyoto, Japan.
   Kyoto Prefectural Univ, Dept Neurol, Div Geriatr Neurol, Res Inst Neurosci Aging, Kyoto 606, Japan.
   Univ Sao Paulo, Dept Geriatr, Sao Paulo, Brazil.
   Univ Sao Paulo, Dept Gerontol Nursing, Sao Paulo, Brazil.
   Fac Odontol, Ctr Estudos Super Maceio, Maceio, Brazil.
   Bur Hlth Care, Estancia Velha Town, Brazil.
   Pontificial Catholic Univ Rio Grande Do Sul, WHO, Inst Gerontol & Geriatr, Collaborating Res Ctr Prevent Chron Degenerat Dis, Rio Grande Do Sul, Brazil.
C3 Kyoto University; Kyoto University; Kyoto University; Kyoto University;
   Kyoto University; Kyoto Prefectural University; Universidade de Sao
   Paulo; Universidade de Sao Paulo; World Health Organization; Pontificia
   Universidade Catolica Do Rio Grande Do Sul
RP Roriz-Cruz, M (corresponding author), Kyoto Univ Hosp, Dept Neurol, 4th Floor,54 Kawahara Cho, Shogoin, Japan.
EM matheusroriz@hotmail.com
RI Rodrigues, Rosalina/C-5714-2013; Sousa, Luísa/JDW-2290-2023; da Cruz;
   Manica da Cruz, Ivana/G-4329-2012
OI da Cruz; Manica da Cruz, Ivana/0000-0003-3008-6899; Roriz Filho,
   Jarbas/0000-0002-5928-0399; Rodrigues, Rosalina Aparecida
   Partezani/0000-0001-8916-1078
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NR 48
TC 69
Z9 74
U1 1
U2 12
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0002-8614
EI 1532-5415
J9 J AM GERIATR SOC
JI J. Am. Geriatr. Soc.
PD MAR
PY 2007
VL 55
IS 3
BP 374
EP 382
DI 10.1111/j.1532-5415.2007.01068.x
PG 9
WC Geriatrics & Gerontology; Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA 140QA
UT WOS:000244519400008
PM 17341239
DA 2025-06-11
ER

PT J
AU Gyawali, P
   Richards, RS
   Nwose, EU
AF Gyawali, Prajwal
   Richards, Ross S.
   Nwose, Ezekiel Uba
TI Erythrocyte morphology in metabolic syndrome
SO EXPERT REVIEW OF HEMATOLOGY
LA English
DT Review
DE diabetes mellitus; erythrocyte morphology; hemorheology; hypertension;
   metabolic syndrome; oxidative stress
ID BLOOD-CELL DEFORMABILITY; RED-CELL; DIABETES-MELLITUS;
   LIPID-PEROXIDATION; SHAPE-PARAMETERS; OXIDATIVE STRESS;
   MOLECULAR-MECHANISM; ENDOTHELIAL-CELLS; MEMBRANE FLUIDITY; FREE-RADICALS
AB The study of erythrocyte morphology is of great importance in the field of hemorheology as the deformability of the circulating cells has a fundamental influence on the rheological properties of the blood. Diabetes mellitus, hypertension, dyslipidemia and obesity (mostly central obesity) are the major components of metabolic syndrome. In this review, we focus on the changes in erythrocyte morphology in different components of metabolic syndrome and also discuss the erythrocyte morphology in regards to oxidative stress a common state of chronic diseases. This article also addresses the problem of inconsistency in the use of nomenclature and technique to identify the abnormal morphology and we recommend the use of standard terminology by all authors.
C1 [Gyawali, Prajwal; Richards, Ross S.] Charles Sturt Univ, Sch Community Hlth, Albury, NSW 2640, Australia.
   [Nwose, Ezekiel Uba] Charles Darwin Univ, Darwin, NT 0909, Australia.
C3 Charles Sturt University; Charles Darwin University
RP Gyawali, P (corresponding author), Charles Sturt Univ, Sch Community Hlth, Albury, NSW 2640, Australia.
EM clbioprajwal@gmail.com
RI Nwose, Ezekiel 'Uba'/I-1333-2018
OI Nwose, Ezekiel 'Uba'/0000-0003-1318-9853; Gyawali,
   Prajwal/0000-0003-0975-5576
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NR 73
TC 31
Z9 31
U1 2
U2 27
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1747-4086
EI 1747-4094
J9 EXPERT REV HEMATOL
JI Expert Rev. Hematol.
PD OCT
PY 2012
VL 5
IS 5
BP 523
EP 531
DI 10.1586/EHM.12.47
PG 9
WC Hematology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Hematology
GA 060FR
UT WOS:000312762400010
PM 23146056
DA 2025-06-11
ER

PT J
AU Deniz, M
   Dogan, M
   Gül, Ö
   Özhan, B
   Agladioglu, SY
   Enli, Y
   Senol, H
AF Deniz, Melis
   Dogan, Mustafa
   Gul, Ozlem
   Ozhan, Bavram
   Agladioglu, Sebahat Yilmaz
   Enli, Yasar
   Senol, Hande
TI Evaluation of cardiovascular system and determination of cardiometabolic
   risk using novel biomarkers in childhood obesity
SO PROGRESS IN PEDIATRIC CARDIOLOGY
LA English
DT Article
DE Obesity; Childhood; Echocardiography; Adrenomedullin; Copeptin
ID METABOLIC SYNDROME; VENTRICULAR DYSFUNCTION; SCIENTIFIC STATEMENT;
   INSULIN-RESISTANCE; PHYSICAL-ACTIVITY; YOUNG COMMITTEE; CHILDREN;
   DISEASE; HYPERTENSION; ADOLESCENTS
AB Background: Obesity is a metabolic disorder that is defined as excessive increase in body fat tissue. Early recognition of obesity in children is essential to prevent complications that may occur in both childhood and adulthood.Objectives: The purpose of this study was to assess cardiometabolic risk and to investigate the association between novel biomarkers and cardiovascular disease in obese children.Methods: This research was performed between June 2014 and January 2015 in the Pamukkale University Faculty of Medicine. Fifty obese children and, 29 healthy children were included in the study. Fasting levels of serum lipids, glucose and insulin, serum copeptin, BNP, and ADM were measured. Thickness of main CIMT and EAT were assessed with 2D echocardiogram. M-mode echocardiographic measurements, mitral and tricuspid valve measurements with PDE, and tricuspid and interventricular septum measurements with TDE were performed in both groups. Treadmill stress testing was performed in the same patient group.Results: Levels of total cholesterol and LDL were significantly higher in obese group. Serum BNP and serum ADM levels were significantly lower in obese group. Left ventricular mass index, CIMT and EAT were statistically higher in obese group. Left ventricular end-systolic diameter, left ventricular end-diastolic diameter, interventricular septum diameter, posterior wall thickness were significantly higher in obese group than in control group. Time to reach target heart rate in treadmill stress testing was significantly shorter in obese group than in control group.Conclusion: Childhood obesity is associated with significant changes in the myocardial structure based on echocardiography. Thickness of carotid intima-media and epicardial fat tissue can be used as predictive markers of atherosclerosis in obese children. Our study demonstrated that exercise capacity is significantly lower, and hemodynamic response to exercise is defective in obese children.
C1 [Deniz, Melis] Pamukkale Univ, Dept Pediat, Fac Med, Denizli, Turkey.
   [Dogan, Mustafa; Gul, Ozlem] Pamukkale Univ, Dept Pediat Cardiol, Fac Med, Denizli, Turkey.
   [Ozhan, Bavram; Agladioglu, Sebahat Yilmaz] Pamukkale Univ, Dept Pediat Endocrinol, Fac Med, Denizli, Turkey.
   [Enli, Yasar] Pamukkale Univ, Fac Med, Dept Biochem, Denizli, Turkey.
   [Senol, Hande] Pamukkale Univ, Dept Biostat, Fac Med, Denizli, Turkey.
   [Deniz, Melis] Mevlana Bulv,29 Yenimahalle, Ankara, Turkey.
C3 Pamukkale University; Pamukkale University; Pamukkale University;
   Pamukkale University; Pamukkale University
RP Deniz, M (corresponding author), Pamukkale Univ, Dept Pediat, Fac Med, Denizli, Turkey.; Deniz, M (corresponding author), Mevlana Bulv,29 Yenimahalle, Ankara, Turkey.
EM mlsdnz@gmail.com
RI Enli, Yaşar/AAB-9154-2020; Gul, Ozlem/ABB-5503-2021; Agladioglu,
   Sebahat/LNP-9235-2024
OI Gul, Ozlem/0000-0002-4415-4437
FU Pamukkale University Scientific Research Projects coordination unit
   [2014TPF046]
FX This study was supported by Pamukkale University Scientific Research
   Projects coordination unit by the decision numbered 2014TPF046 (date:
   18.11.2014) .
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NR 32
TC 0
Z9 0
U1 1
U2 4
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 1058-9813
EI 1558-1519
J9 PROG PEDIATR CARDIOL
JI Prog. Pediatr. Cardiol.
PD MAR
PY 2023
VL 68
AR 101605
DI 10.1016/j.ppedcard.2022.101605
EA DEC 2022
PG 6
WC Cardiac & Cardiovascular Systems; Pediatrics
WE Emerging Sources Citation Index (ESCI)
SC Cardiovascular System & Cardiology; Pediatrics
GA 7N9YH
UT WOS:000907690400002
DA 2025-06-11
ER

PT J
AU Dong, RH
   Chen, JS
   Zheng, JH
   Zhang, MR
   Zhang, H
   Wu, M
   Li, SG
   Chen, B
AF Dong, RuiHua
   Chen, JingSi
   Zheng, JianHeng
   Zhang, MeiRu
   Zhang, Han
   Wu, Min
   Li, ShuGuang
   Chen, Bo
TI The role of oxidative stress in cardiometabolic risk related to
   phthalate exposure in elderly diabetic patients from Shanghai
SO ENVIRONMENT INTERNATIONAL
LA English
DT Article
DE Phthalates; Cardiometabolic risk; Oxidative stress;
   gamma-Glutamiltransferase
ID GAMMA-GLUTAMYL-TRANSFERASE; NATIONAL-HEALTH; DI-2-ETHYLHEXYLPHTHALATE
   REPLACEMENTS; CIRCULATING LEVELS; DIETHYL PHTHALATE; BLOOD-PRESSURE;
   ASSOCIATION; METABOLITES; CHILDREN; GLUTAMYLTRANSFERASE
AB The effect of human exposure to phthalates and consequent contribution to the development of cardiometabolic health problems is unknown. However, oxidative stress has been established as playing an important role in the pathogenesis of cardiometabolic outcomes. In this study, we aimed to explore whether exposure to phthalate metabolites could induce cardiometabolic risk by increasing oxidative stress in a diabetic population from Shanghai. We collected paired blood and urine samples from a total of 300 volunteers, and measured 10 phthalate metabolites in urine and biomarkers of oxidative stress from serum including glucose and lipid levels, and liver and kidney damage. The insulin resistance (IR) risk was assessed by the surrogate indices including homeostasis model assessment-insulin resistance (HOMA-IR) and triglyceride glucose (TyG). We used multi variable linear regression to assess the association between phthalates and these physiological parameters. Mediation and modification analyses were performed to identify the role that oxidative stress played in the underlying mechanisms. The results showed that most of the determined phthalate metabolites were positively associated with HOMA-IR, 8-hydroxy-2'-deoxyguanosine (8-OHDG), and malondialdehyde (MDA). In the mediation analysis, only gamma-glutamiltransferase (GGT) was found to be a significant mediator of the association between phthalates and TyG. In the modification analysis, exposure to phthalates strengthened the association between oxidative stress (MDA and 8-OHDG) and HOMA-IR. Our findings demonstrate that exposure to phthalates might be positively associated with elevated IR and oxidative stress. The direct participation (mediation effect) of GGT might play an important mechanism in promoting IR.
C1 [Dong, RuiHua; Chen, JingSi; Zheng, JianHeng; Zhang, MeiRu; Zhang, Han; Wu, Min; Li, ShuGuang; Chen, Bo] Fudan Univ, Sch Publ Hlth, Collaborat Innovat Ctr Social Risks Governance Hl, Key Lab Publ Hlth Safety,Minist Educ, Shanghai 200032, Peoples R China.
   [Zheng, JianHeng] Shanghai Res Inst Sports Sci, Key Lab State Gen Adm Sport, Shanghai 200030, Peoples R China.
   [Zhang, MeiRu] Shanghai Xuhui Ctr Dis Control & Prevent, Environm Hlth & Occupat Hlth Dept, Shanghai 200030, Peoples R China.
C3 Fudan University; Ministry of Education - China; Shanghai Center for
   Disease Control & Prevention
RP Li, SG; Chen, B (corresponding author), Fudan Univ, Sch Publ Hlth, Collaborat Innovat Ctr Social Risks Governance Hl, Key Lab Publ Hlth Safety,Minist Educ, Shanghai 200032, Peoples R China.
EM 15111020019@fudan.edu.cn; 15211020022@fudan.edu.cn;
   15111020021@fudan.edu.cn; 14211020025@fudan.edu.cn;
   13211020025@fudan.edu.cn; wumin@shmu.edu.cn; leeshuguang@fudan.edu.cn;
   chenb@fudan.edu.cn
RI 李, 曙光/JEO-8001-2023; bo, chen/M-1290-2019
FU National Key Research and Development Program of China [2016YFD0400602]
FX This work was supported by the National Key Research and Development
   Program of China [grant numbers 2016YFD0400602].
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NR 46
TC 42
Z9 44
U1 4
U2 40
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0160-4120
EI 1873-6750
J9 ENVIRON INT
JI Environ. Int.
PD DEC
PY 2018
VL 121
BP 340
EP 348
DI 10.1016/j.envint.2018.09.028
PN 1
PG 9
WC Environmental Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology
GA GZ0RA
UT WOS:000449071000037
PM 30243182
OA hybrid
DA 2025-06-11
ER

PT J
AU Paslakis, G
   Gilles, M
   Lederbogen, F
   Schilling, C
   Scharnholz, B
   Deuschle, M
AF Paslakis, Georgios
   Gilles, Maria
   Lederbogen, Florian
   Schilling, Claudia
   Scharnholz, Barbara
   Deuschle, Michael
TI The effect of a 4-week treatment with reboxetine on metabolic parameters
   of depressed inpatients
SO EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
LA English
DT Article
DE Depression; Metabolic syndrome; Antidepressant; Reboxetine; HPA axis;
   Cortisol
ID IMPROVED INSULIN SENSITIVITY; INCREASED INTRAABDOMINAL FAT;
   HYPERCORTISOLEMIC DEPRESSION; DOUBLE-BLIND; RESISTANCE; SYMPTOMS;
   METAANALYSIS; PREVALENCE; ADULTS; TRIAL
AB In the present study, we examined several metabolic parameters in a group of 19 acutely depressed inpatients with major depression (DSM-IV) at baseline and investigated their development after 4 weeks of antidepressant treatment with reboxetine (8-12 mg per day). We performed oral glucose tolerance tests and additionally assessed free saliva cortisol and post-dexamethasone cortisol levels, as well as whole cholesterol, HDL- and LDL-cholesterol, triglycerides, free fatty acids, waist and hip circumference, heart rate, systolic and diastolic blood pressure. Furthermore, we evaluated the incidence of a metabolic syndrome and investigated the metabolic changes in depressed patients with and without a metabolic syndrome. We found 42.1% of patients to fulfil the criteria for a metabolic syndrome. Overall, reboxetine was well tolerated with essentially no side effects during the observation period. A 4-week treatment with reboxetine showed a beneficial effect on several metabolic parameters that was independent from treatment outcome and could therefore theoretically be attributed to the pharmacological profile of the drug. Due to the preliminary character of the present investigation, no conclusions about the clinical efficacy of reboxetine can be drawn.
C1 [Paslakis, Georgios; Gilles, Maria; Lederbogen, Florian; Schilling, Claudia; Scharnholz, Barbara; Deuschle, Michael] Cent Inst Mental Hlth, Dept Psychiat & Psychotherapy, D-68159 Mannheim, Germany.
C3 Central Institute of Mental Health
RP Paslakis, G (corresponding author), Cent Inst Mental Hlth, Dept Psychiat & Psychotherapy, J5, D-68159 Mannheim, Germany.
EM Georgios.Paslakis@zi-mannheim.de
RI Deuschle, Michael/E-4638-2012; paslakis, georgios/KRQ-5450-2024;
   Schilling, Claudia/AFK-8298-2022
OI paslakis, georgios/0000-0002-2069-0024
FU Merz Pharmaceuticals, Frankfurt, Germany
FX This study was supported by an unrestricted grant by Merz
   Pharmaceuticals, Frankfurt, Germany.
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NR 22
TC 8
Z9 8
U1 0
U2 2
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0940-1334
J9 EUR ARCH PSY CLIN N
JI Eur. Arch. Psych. Clin. Neurosci.
PD APR
PY 2011
VL 261
IS 3
BP 173
EP 177
DI 10.1007/s00406-010-0164-4
PG 5
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Psychiatry
GA 746OQ
UT WOS:000289257000005
PM 21053006
DA 2025-06-11
ER

PT J
AU Liu, YH
   Ma, LL
   Hu, LK
   Cui, L
   Li, YL
   Chen, N
   Yang, K
   Zhang, Y
   Yan, YX
AF Liu, Yu-Hong
   Ma, Lin-Lin
   Hu, Li-Kun
   Cui, Lu
   Li, Yan-Ling
   Chen, Ning
   Yang, Kun
   Zhang, Yu
   Yan, Yu-Xiang
TI The joint effects of sarcopenia and cardiometabolic risk factors on
   declined cognitive function: Evidence from a 7-year cohort study
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Sarcopenia; Cognitive function; Cardiometabolic risk factors; Cohort
   study
ID SKELETAL-MUSCLE; ALTERNATIVE DEFINITIONS; INSULIN-RESISTANCE; OXIDATIVE
   STRESS; WORKING GROUP; CHINA HEALTH; IMPAIRMENT; OBESITY; INFLAMMATION;
   DEMENTIA
AB Background: Sarcopenia and cardiometabolic risk factors are very common in the middle-aged and older population. This study aimed to explore the joint effect of sarcopenia and cardiometabolic risk factors on cognitive performance and cognitive decline. Methods: The definition of sarcopenia status was referenced in the AWGS 2019 algorithm. Linear regression models were used to explore the association of sarcopenia status with cognitive performance at baseline. Mixed effect models and multinomial logistic regression models were used to evaluate the long-term effect of sarcopenia status. The additive interaction between the effects of sarcopenia and cardiometabolic risk factors on cognitive performance was also evaluated. Results: In the cross-sectional analysis, sarcopenia and possible sarcopenia were associated with worse cognitive performance. In the longitudinal analysis, the participant with sarcopenia had a 0.34 [95 % CI (-0.43,-0.24)] lower global cognition score, and those with possible sarcopenia had a 0.20 [95 % CI (-0.27,-0.14)] lower global cognition score, compared with participants with no-sarcopenia. Sarcopenia and possible sarcopenia were identified as significant risk factors for cognitive decline. Sarcopenia combined with hypertension, type 2 diabetes, dyslipidemia, or abdominal obesity was associated with worse cognitive function. Limitations: The assessment of cognitive function was not diagnosed accurately. Conclusions: Sarcopenia and possible sarcopenia had adverse effects on cognitive performance and cognitive decline, sarcopenia combined with cardiometabolic risk factors can significantly enhance these effects. Therefore, the prevention of sarcopenia in the older population is crucial.
C1 [Liu, Yu-Hong; Ma, Lin-Lin; Hu, Li-Kun; Cui, Lu; Li, Yan-Ling; Chen, Ning; Yang, Kun; Zhang, Yu; Yan, Yu-Xiang] Capital Med Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing 100069, Peoples R China.
   [Liu, Yu-Hong] Nanchang Ctr Dis Control & Prevent, Nanchang 330038, Peoples R China.
   [Yan, Yu-Xiang] Municipal Key Lab Clin Epidemiol, Beijing 100069, Peoples R China.
   [Yan, Yu-Xiang] Capital Med Univ, Sch Publ Hlth, 10 Xitoutiao, Beijing 100069, Peoples R China.
C3 Capital Medical University; Capital Medical University
RP Yan, YX (corresponding author), Capital Med Univ, Sch Publ Hlth, 10 Xitoutiao, Beijing 100069, Peoples R China.
EM yanyxepi@ccmu.edu.cn
RI Chen, Ning/IVH-6535-2023; LINLIN, MA/GZM-6143-2022
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NR 67
TC 3
Z9 3
U1 5
U2 26
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD JAN 1
PY 2024
VL 344
BP 644
EP 652
DI 10.1016/j.jad.2023.10.056
EA OCT 2023
PG 9
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA X9HU6
UT WOS:001101487600001
PM 37852588
DA 2025-06-11
ER

PT J
AU Esposito, K
   Ciotola, M
   Schisano, B
   Misso, L
   Giannetti, G
   Ceriello, A
   Gugliano, D
AF Esposito, K.
   Ciotola, M.
   Schisano, B.
   Misso, L.
   Giannetti, G.
   Ceriello, A.
   Gugliano, D.
TI Oxidative stress in the metabolic syndrome
SO JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
LA English
DT Article
DE metabolic syndrome; nitrotyrosine; endothelium-dependent vasocilation;
   insulin resistance
ID NITRIC-OXIDE SYNTHASE; ENDOTHELIAL DYSFUNCTION; INSULIN-RESISTANCE;
   CARDIOVASCULAR-DISEASE; DENSITY-LIPOPROTEIN; HYPERGLYCEMIA;
   INFLAMMATION; ASSOCIATION; THERAPY; OBESITY
AB The metabolic syndrome represents a cluster of several risk factors for atherosclerosis that increases the risk of future cardiovascular events. In this study, we evaluated whether oxidative stress is increased in subjects with the metabolic syndrome. We studied 100 subjects (50 men and 50 women) with the metabolic syndrome, as defined by the Adult Treatment Panel III, and 50 (25 men and 25 women) matched subjects without the syndrome. Insulin sensitivity was assessed with the homeostasis model assessment (HOMA) methods; endothelium-dependent flow-mediated vasodilation (FMD) was evaluated in the right brachial artery with a high-resolution ultrasound machine; oxidative stress was assessed by measuring the circulating levels of nitrotyrosine (NT), considered a good marker for the formation of endogenous peroxynitrite. Compared with control subjects, patients with the metabolic syndrome had greater waist circumference, higher HOMA and systolic pressure values, higher triglyceride and lower HDL-cholesterol levels. NT levels were higher (0.44 +/- 0.12 mu mol/l, mean +/- SD) while FMD was lower [7.3 (4.4/9.6), median and interquartile range] in subjects with the metabolic syndrome as compared with control subjects [0.27 +/- 0.08 and 11.8 (8.6/14.9), respectively, p < 0.001]. There was an increase in NT levels and HOMA score as the number of components of the metabolic syndrome increased. NT levels were associated with waist circumference (r=0.38, p=0.01), triglycerides (r=0.32, p < 0.02), systolic blood pressure (r=0.21, p < 0.05) and fasting glucose (r=0.24, p < 0.05). The oxidative stress that accompanies the metabolic syndrome is associated with both insulin resistance and endothelial dysfunction, providing a connection which is highly deleterious for vascular functions.
C1 Univ Naples SUN, Div Metab Dis, Dept Geriatr & Metab Dis, Naples, Italy.
   Warwick Med Sch, Coventry, W Midlands, England.
C3 University of Warwick
RP Gugliano, D (corresponding author), Policlin SUN, Div Metab Dis, Piazza L Miraglia, I-80138 Naples, Italy.
EM dario.giugliano@unina2.it
RI Esposito, Katherine/AHE-2564-2022; Ceriello, Antonio/J-9575-2016
OI Ceriello, Antonio/0000-0001-8122-3203; Giugliano,
   Dario/0000-0002-9377-873X
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NR 32
TC 63
Z9 69
U1 0
U2 7
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0391-4097
EI 1720-8386
J9 J ENDOCRINOL INVEST
JI J. Endocrinol. Invest.
PD OCT
PY 2006
VL 29
IS 9
BP 791
EP 795
DI 10.1007/BF03347372
PG 5
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 111DF
UT WOS:000242430900006
PM 17114909
DA 2025-06-11
ER

PT J
AU Wang, YF
   Xu, T
   Zhang, Y
   He, Y
   Fang, JX
   Xu, Y
   Jin, LN
AF Wang, Yanfang
   Xu, Tong
   Zhang, Yuan
   He, Yue
   Fang, Jiaxin
   Xu, Yan
   Jin, Lina
TI Interaction between depression and non-essential heavy metals (Cd, Pb,
   and Hg) on metabolic diseases
SO JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
LA English
DT Article
DE Interaction; Depression; Heavy metals; Metabolic diseases
ID TYPE-2 DIABETES-MELLITUS; KOREA NATIONAL-HEALTH; OXIDATIVE STRESS;
   EXPOSURE; RISK; ASSOCIATION; CADMIUM; LEAD; HYPERTENSION; METAANALYSIS
AB Objectives: Metal exposure and depression have each been associated with adverse metabolic diseases, but no study has examined the potential interaction between them. We examined the interaction of depression on the association between metals and metabolic diseases among adults. Study design: The interaction of depression in the relationship between metal and metabolic disease in adults was investigated using NHANES, a cross-sectional survey design. Methods: By employing data from the NHANES database spanning the years 2007-2018, regression models were employed to investigate the independent impacts of heavy metals (cadmium, lead, and mercury) and depression on metabolic diseases (type 2 diabetes, hypertension, hyperlipidemia, metabolic syndrome). Subsequently, the association between metals and metabolic diseases was explored stratified by depression, and the interaction between heavy metals and depression was explored. Because of the complex NHANES design, statistical evaluations were adjusted through weighting to represent the populace of the United States. Results: We found log transformed-urinary lead was significantly associated with type 2 diabetes (OR: 2.33; 95 % CI: 1.23, 4.41) in adults with depression. Log transformed-urinary lead was not associated with type 2 diabetes (OR: 0.84; 95 % CI: 0.56, 1.27) in adults without depression. The interaction between Pb and depression in type 2 diabetes was significant (P for interaction = 0.033). Log transformed-urinary lead * depression was significantly associated with type 2 diabetes (OR: 1.82; 95 % CI: 1.01, 3.34) in adults. There was no significant interaction between cadmium and mercury exposure and depression in patients with type 2 diabetes, hypertension, hyperlipidemia, and metabolic syndrome (P for interaction > 0.05). Conclusions: The presence of depression positively modified the adverse associations between urinary lead and type 2 diabetes.
C1 [Wang, Yanfang; Xu, Tong; Zhang, Yuan; He, Yue; Fang, Jiaxin; Xu, Yan; Jin, Lina] Jilin Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, 1163 Xinmin St, Changchun 130021, Jilin, Peoples R China.
C3 Jilin University
RP Jin, LN (corresponding author), Jilin Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, 1163 Xinmin St, Changchun 130021, Jilin, Peoples R China.
EM jinln@jlu.edu.cn
RI xu, yan/LPP-9769-2024
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NR 51
TC 4
Z9 4
U1 4
U2 17
PU ELSEVIER GMBH
PI MUNICH
PA HACKERBRUCKE 6, 80335 MUNICH, GERMANY
SN 0946-672X
EI 1878-3252
J9 J TRACE ELEM MED BIO
JI J. Trace Elem. Med. Biol.
PD SEP
PY 2024
VL 85
AR 127484
DI 10.1016/j.jtemb.2024.127484
EA JUN 2024
PG 10
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA XO1V6
UT WOS:001262543400001
PM 38924924
DA 2025-06-11
ER

PT J
AU Gildengers, A
   Tatsuoka, C
   Bialko, C
   Cassidy, KA
   Al Jurdi, RK
   Gyulai, L
   Mulsant, BH
   Young, RC
   Sajatovic, M
AF Gildengers, Ariel
   Tatsuoka, Curtis
   Bialko, Christopher
   Cassidy, Kristin A.
   Al Jurdi, Rayan K.
   Gyulai, Laszlo
   Mulsant, Benoit H.
   Young, Robert C.
   Sajatovic, Martha
TI Correlates of Treatment Response in Depressed Older Adults With Bipolar
   Disorder
SO JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY
LA English
DT Article
DE bipolar disorder; elderly; geriatric; lamotrigine; mood stabilizer;
   anticonvulsant; depression
ID WEEKLY SYMPTOMATIC STATUS; RATING-SCALE; II DISORDER;
   ANTIDEPRESSANT-TREATMENT; SUICIDAL-BEHAVIOR; NATURAL-HISTORY; TRIAL;
   LIFE; PREVENTION; PLASTICITY
AB Aims: To identify baseline clinical factors associated with acute treatment response in depressed older adults with bipolar disorder (BD) receiving lamotrigine. Methods: Secondary analysis of a multisite, 12-week, open-label, uncontrolled study of add-on lamotrigine in 57 adults 60 years and older with BD I or II depression. Measures included the Montgomery Asberg Depression Rating Scale (MADRS) and Young Mania Rating Scale (YMRS). Cardiometabolic risk was measured with total serum cholesterol and the Cumulative Illness Rating Scale-Geriatric (CIRS-G) item # 13 (endocrine/metabolic burden). Neurocognitive (executive) function was evaluated using the Trail Making Test. Results: Greater reduction in MADRS from baseline was associated with higher baseline cardiometabolic burden at 6 and 9 weeks and lower YMRS scores at 9 weeks. At 12 weeks, improvement in the MADRS from baseline was no longer significantly related to baseline cardiometabolic burden or YMRS scores. A longitudinal mixed model of MADRS scores corroborated these findings with a significant finding of time-by-baseline cholesterol level interaction. In a subset of participants, better baseline executive function was related to greater improvement in the MADRS at 9 weeks but not at 6 or 12 weeks. Among all participants, higher baseline YMRS scores were related to greater likelihood of dropout. Conclusions: Lamotrigine appears to work best in depressed elderly patients with BD who have high cardiometabolic risk and low level of mania. Agents like lamotrigine that act primarily on neuroprogressive pathways involving oxidative stress, neurotrophins, and inflammation may be particularly effective in individuals with BD who have significant cardiometabolic burden because of their effects on shared vulnerability factors in BD and medical illness.
C1 [Gildengers, Ariel] Univ Pittsburgh, Sch Med, Dept Psychiat, Western Psychiat Inst & Clin, Pittsburgh, PA 15213 USA.
   [Tatsuoka, Curtis] Case Western Reserve Univ, Sch Med, Dept Neurol, Univ Hosp Case Med Ctr, Cleveland, OH 44106 USA.
   [Bialko, Christopher; Cassidy, Kristin A.; Sajatovic, Martha] Case Western Reserve Univ, Sch Med, Dept Psychiat, Univ Hosp Case Med Ctr, Cleveland, OH 44106 USA.
   [Al Jurdi, Rayan K.] Baylor Coll Med, VA Med Ctr, Houston, TX 77030 USA.
   [Gyulai, Laszlo] Univ Penn, Med Ctr, Philadelphia, PA 19104 USA.
   [Gyulai, Laszlo] Univ Penn, Sch Med, Philadelphia, PA 19104 USA.
   [Mulsant, Benoit H.] Univ Toronto, Ctr Addict & Mental Hlth, Toronto, ON, Canada.
   [Young, Robert C.] Weill Cornell Med Coll, Dept Psychiat, New York, NY USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE); University
   of Pittsburgh; Western Psychiatric Institute & Clinic of UPMC;
   University System of Ohio; Case Western Reserve University; Case Western
   Reserve University Hospital; University System of Ohio; Case Western
   Reserve University; Case Western Reserve University Hospital; Baylor
   College of Medicine; US Department of Veterans Affairs; Veterans Health
   Administration (VHA); Michael E DeBakey VA Medical Center; University of
   Pennsylvania; University of Pennsylvania; University of Toronto; Centre
   for Addiction & Mental Health - Canada; Cornell University; Weill
   Cornell Medicine
RP Gildengers, A (corresponding author), Univ Pittsburgh, Sch Med, Dept Psychiat, Western Psychiat Inst & Clin, 3811 OHara St, Pittsburgh, PA 15213 USA.
EM gildengersag@upmc.edu
RI Sajatovic, Martha/I-8001-2014; Tatsuoka, Curtis/HLX-2752-2023
OI Gildengers, Ariel/0000-0001-9216-988X; Mulsant,
   Benoit/0000-0002-0303-6450; Young, Robert/0000-0002-6380-6314
FU GlaxoSmithKline, Research Triangle Park, North Carolina, USA; Case
   Western Reserve University [UL1RR024989]; GlaxoSmithKline; Canadian
   Institutes of Health Research; NIH; Bristol-Myers Squibb; Wyeth;
   AstraZeneca; Janssen; Pfizer; Merck; Ortho-McNeil Janssen
FX The authors disclosed receipt of the following financial support for the
   research, authorship, and/or publication of this article: This study was
   supported by an investigator-initiated research grant from
   GlaxoSmithKline, Research Triangle Park, North Carolina, USA, and grant
   UL1RR024989 from Case Western Reserve University Clinical and
   Translational Science Awards (CTSA). The CTSA is a component of the
   National Institute of Health (NIH) and NIH Roadmap for Medical Research.
   The contents are solely the responsibility of the authors and do not
   necessarily represent the official view of the National Center for
   Research Resources or the NIH. Ariel Gildengers, Rayan K. Al-Jurdi,
   Laszlo Gyulai, and Robert C. Young received funding for research from
   GlaxoSmithKline to conduct this investigator-initiated study. Benoit H.
   Mulsant has received funding for research from GlaxoSmithKline, the
   Canadian Institutes of Health Research, NIH, Bristol-Myers Squibb, and
   Wyeth. Robert C. Young has received funding for research from NIH,
   GlaxoSmithKline, AstraZeneca, and Janssen. Martha Sajatovic received
   research grants from AstraZeneca, Pfizer, Merck, and Ortho-McNeil
   Janssen; is a consultant for Cognition Group and United BioSource
   Corporation (Bracket); and receives royalties from Springer Press, Johns
   Hopkins University Press, and Oxford Press. All other authors have no
   conflicts to report.
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NR 42
TC 8
Z9 9
U1 0
U2 7
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0891-9887
J9 J GERIATR PSYCH NEUR
JI J. Geriatr. Psychiatry Neurol.
PD MAR
PY 2012
VL 25
IS 1
SI SI
BP 37
EP 42
DI 10.1177/0891988712436685
PG 6
WC Geriatrics & Gerontology; Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology; Neurosciences & Neurology; Psychiatry
GA 923NM
UT WOS:000302626000007
PM 22467845
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Teh, WL
   Abdin, E
   Vaingankar, JA
   Shafie, S
   Jeyagurunathan, A
   Zhang, YJ
   Subramaniam, M
AF Teh, Wen Lin
   Abdin, Edimansyah
   Vaingankar, Janhavi Ajit
   Shafie, Saleha
   Jeyagurunathan, Anitha
   Zhang Yunjue
   Subramaniam, Mythily
TI Prevalence, Lifestyle Correlates, and Psychosocial Functioning Among
   Multi-Ethnic Older Adults with Mild Cognitive Impairment in Singapore:
   Preliminary Findings from a 10/66 Population Study
SO YALE JOURNAL OF BIOLOGY AND MEDICINE
LA English
DT Article
DE Mild Cognitive Impairment; Smoking; Alcohol use; Physical activity;
   Amnestic Mild Cognitive Impairment
ID MODERATE ALCOHOL-CONSUMPTION; DEMENTIA PREVENTION; METABOLIC SYNDROME;
   PHYSICAL-EXERCISE; MENTAL-HEALTH; RISK; PROGRESSION; DEPRESSION;
   SUBTYPES; LONELINESS
AB Asia, which has the highest increase in dementia prevalence, is unfortunately lacking recent up-to-date research, with regions of Southeast Asia being the most inadequate. Preventive approaches, such as the understanding of Mild Cognitive Impairment (MCI), are currently the most effective approach in reducing the risk or delaying the onset of dementia but are not adequately understood. Additionally, there is a paucity of research examining lifestyle and sociodemographic correlates of MCI that are relevant to the local population of Singapore. To address these gaps, this study aimed to explore: 1) the prevalence of MCI and Amnestic Mild Cognitive Impairment (aMCI), 2) the psychosocial and lifestyle correlates of MCI and aMCI. Data were drawn from the Well-being of the Singapore Elderly (WiSE) population study, which is a single-phase cross-sectional household survey conducted among older adult residents aged 60 years and above. Analyses revealed that the weighted MCI prevalence (1.2%) was lower than global figures. Few sociodemographic and lifestyle habits were related to MCI prevalence, as only age and physical activeness emerged as significant correlates. Despite the low prevalence of MCI, individuals with MCI experienced marked disability, clinical levels of depression and anxiety, which are all concerning finds. Due to the exploratory and cross-sectional nature of the study, future longitudinal research could further refine our understanding of MCI and confirm the present findings.
C1 [Teh, Wen Lin; Abdin, Edimansyah; Vaingankar, Janhavi Ajit; Shafie, Saleha; Jeyagurunathan, Anitha; Zhang Yunjue; Subramaniam, Mythily] Inst Mental Hlth, Res Div, Buangkok Green Med Pk,10 Buangkok View, Singapore 539747, Singapore.
RP Teh, WL (corresponding author), Inst Mental Hlth, Res Div, Buangkok Green Med Pk,10 Buangkok View, Singapore 539747, Singapore.
EM Wen_Lin_Teh@imh.com.sg
RI Abdin, Edimansyah/E-6451-2011
OI Abdin, Edimansyah/0000-0002-1016-3298; Teh, Wen Lin/0000-0002-7641-8521
FU Ministry of Health, Singapore; Singapore Millennium Foundation of the
   Temasek Trust
FX This study was funded by the Ministry of Health, Singapore, and the
   Singapore Millennium Foundation of the Temasek Trust.
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NR 83
TC 14
Z9 14
U1 3
U2 10
PU YALE J BIOLOGY MEDICINE, INC
PI NEW HAVEN
PA 333 CEDAR ST, PO BOX 208000, NEW HAVEN, CT 06520-8000 USA
SN 0044-0086
EI 1551-4056
J9 YALE J BIOL MED
JI Yale J. Biol. Med.
PD MAR
PY 2021
VL 94
IS 1
BP 73
EP 83
PG 11
WC Biology; Medicine, General & Internal; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Life Sciences & Biomedicine - Other Topics; General & Internal Medicine;
   Research & Experimental Medicine
GA TD7YU
UT WOS:000669538200008
PM 33795984
DA 2025-06-11
ER

PT J
AU Guo, XW
   Zhou, DM
   Sun, LY
   Wang, P
   Qu, JH
   Zhang, C
   Wang, Y
   Chen, ZX
   Li, B
   Hu, J
   Lin, ZM
   Shi, F
   Bai, YP
   Li, YW
   Duan, XW
   Bao, ST
   Lan, HB
   Sun, XY
   Wang, X
   Liu, X
   Li, LG
   Zhang, LT
   Feng, F
   Meng, YJ
   Liu, QW
   Guo, XY
   Guo, JN
   Liu, Y
   Qi, C
   Chen, J
   Feng, S
   Li, P
AF Guo, Xinwei
   Zhou, Dongmei
   Sun, Liyun
   Wang, Ping
   Qu, Jianhua
   Zhang, Cang
   Wang, Yan
   Chen, Zhaoxia
   Li, Bo
   Hu, Jing
   Lin, Zhimiao
   Shi, Fei
   Bai, Yanping
   Li, Yuanwen
   Duan, Xingwu
   Bao, Shentao
   Lan, Haibing
   Sun, Xiaoyan
   Wang, Xiong
   Liu, Xiang
   Li, Linge
   Zhang, Litao
   Feng, Fang
   Meng, Yujiao
   Liu, Qingwu
   Guo, Xiaoyao
   Guo, Jianning
   Liu, Yu
   Qi, Cong
   Chen, Jia
   Feng, Shuo
   Li, Ping
TI Traditional Chinese medicine for psoriasis vulgaris A Protocol of a
   prospective, multicenter cohort study
SO MEDICINE
LA English
DT Article
DE cohort study design; long-term efficacy; psoriasis vulgaris; recurrence;
   traditional Chinese medicine
ID EPIDEMIOLOGY; REGISTRY
AB Introduction: The incidence of psoriasis vulgaris is increasing worldwide. Chronic recurrence of the disease, as well as accompanying cardiovascular disease, metabolic syndrome, and depression has affected the physical and mental health of these patients. Psoriasis vulgaris is a difficult and major disease in the dermatology field. Short-term curative effects using conventional therapy for psoriasis vulgaris has made major strides. However, traditional Chinese medicine (TCM) treatment has long-term curative advantages for psoriasis vulgaris but lacks the scientific and clinical evidence for its use. This study intends to demonstrate and provide scientific and clinical evidence for the use of TCM to delay the recurrence of psoriasis vulgaris. Methods and analysis: This will be a prospective, multicenter cohort study. We intend to recruit 1521 psoriasis vulgaris patients from 14 hospitals in Beijing, Tianjin, and Hebei. Treatment will be based on the diagnosis specifications and clinical practice guidelines of TCM and conventional therapy. During inclusion and the subsequent follow-up period, doctors through electronic case reports will collect different therapeutic TCM regimens and conventional therapy that were administered. Information on life condition, skin lesions at each visit, World Health Organization Quality of Life Instruments, Zung Self-rating Anxiety Scale, Zung Self-assessment of Depression, laboratory examinations, incidence of new rash and recurrence during the remission and recurrence stages will be recorded. Ethics and dissemination: The clinical trial protocol for this study was approved by the ethics committee of the Beijing hospital of TCM affiliated to capital medical university (Ethics number: 2019BL02-010-02). We will publish and present our results at national and international conferences and in peer-reviewed journals specialized in dermatology.
C1 [Guo, Xinwei; Wang, Yan; Chen, Zhaoxia; Li, Bo; Hu, Jing; Feng, Fang; Meng, Yujiao; Liu, Qingwu; Guo, Xiaoyao; Guo, Jianning; Liu, Yu; Qi, Cong; Chen, Jia; Feng, Shuo; Li, Ping] Capital Med Univ, Beijing Inst Tradit Chinese Med, Beijing Hosp Tradit Chinese Med, 23 Meishuguanhou St, Beijing 100010, Peoples R China.
   [Zhou, Dongmei; Sun, Liyun; Wang, Ping; Qu, Jianhua; Zhang, Cang] Capital Med Univ, Beijing Hosp Tradit Chinese Med, Beijing, Peoples R China.
   [Lin, Zhimiao] Peking Univ First Hosp, Beijing, Peoples R China.
   [Shi, Fei] Air Force Gen Hosp, PLA, Beijing, Peoples R China.
   [Bai, Yanping] China Japan Friendship Hosp, Beijing, Peoples R China.
   [Li, Yuanwen] Beijing Univ Chinese Med, Dongfang Hosp, Beijing, Peoples R China.
   [Duan, Xingwu] Beijing Univ Chinese Med, Affiliated Dongzhimen Hosp, Beijing, Peoples R China.
   [Bao, Shentao] Beijing Univ Chinese Med, Affiliated Hosp 3, Beijing, Peoples R China.
   [Sun, Liyun] Beijing Hosp Tradit Chinese Med, Shunyi Branch, Beijing, Peoples R China.
   [Lan, Haibing] Beijing Gulou Hosp Tradit Chinese Med, Beijing, Peoples R China.
   [Sun, Xiaoyan] Beijing Daxing Dist Peoples Hosp, Beijing, Peoples R China.
   [Wang, Xiong] Tradit Chinese Med Hosp Beijing Miyun, Beijing, Peoples R China.
   [Liu, Xiang] Hebei Prov Hosp Tradit Chinese Med, Wuhan, Peoples R China.
   [Li, Linge] Tradit Chinese Med Hosp Shijiazhuang City, Shijiazhuang, Hebei, Peoples R China.
   [Zhang, Litao] Tianjin Acad Tradit Chinese Med, Affiliated Hosp, Dermatol Dept, Tianjin, Peoples R China.
C3 Capital Medical University; Capital Medical University; Peking
   University; Air Force General Hospital PLA; China-Japan Friendship
   Hospital; Beijing University of Chinese Medicine; Beijing University of
   Chinese Medicine; Beijing University of Chinese Medicine; Hebei
   University of Chinese Medicine
RP Feng, S; Li, P (corresponding author), Capital Med Univ, Beijing Inst Tradit Chinese Med, Beijing Hosp Tradit Chinese Med, 23 Meishuguanhou St, Beijing 100010, Peoples R China.
EM fengshuo_1988@126.com; liping411@126.com
RI chen, zx/LTZ-5635-2024; wang, xiaoyu/HJP-6901-2023; sun,
   xiaoyan/D-3644-2016; Guo, Jianning/MFJ-9699-2025; Lan,
   Haibing/AAN-7561-2020; Li, Bo/AAA-8968-2020; Wang, Ping/AAA-5363-2022
FU Beijing Institute of TCM; dermatology department of Peking University
   First Hospital; dermatology department of Air Force General Hospital,
   PLA; dermatology department of China-Japan Friendship Hospital;
   dermatology department of Beijing University of Chinese Medicine
   Affiliated Dongzhimen Hospital; dermatology department of Dongfang
   Hospital Beijing University of Chinese Medicine; dermatology department
   of Beijing University of Chinese Medicine Third Affiliated Hospital;
   dermatology department ofBeijing Hospital of TCM Shunyi Branch;
   dermatology department of Beijing Gulou Hospital of TCM; dermatology
   department of Beijing Daxing District People's Hospital; dermatology
   department of TCM hospital of Beijing Miyun; dermatology department of
   Hebei Province Hospital of TCM; dermatology department of TCM Hospital
   of Shijiazhuang City; dermatology department of Tianjin Academy of TCM
   Affiliated Hospital
FX This study was sponsored by Beijing Institute of TCM, and supported by
   the dermatology departments of Peking University First Hospital, Air
   Force General Hospital, PLA, China-Japan Friendship Hospital, Beijing
   University of Chinese Medicine Affiliated Dongzhimen Hospital, Dongfang
   Hospital Beijing University of Chinese Medicine, Beijing University of
   Chinese Medicine Third Affiliated Hospital, Beijing Hospital of TCM
   Shunyi Branch, Beijing Gulou Hospital of TCM, Beijing Daxing District
   People's Hospital, TCM hospital of Beijing Miyun, Hebei Province
   Hospital of TCM, TCM Hospital of Shijiazhuang City, and Tianjin Academy
   of TCM Affiliated Hospital.
CR Bernhardt Mark, 2016, Skinmed, V14, P453
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NR 24
TC 6
Z9 9
U1 1
U2 19
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD OCT 9
PY 2020
VL 99
IS 41
AR e21913
DI 10.1097/MD.0000000000021913
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA OC6DZ
UT WOS:000579245800004
PM 33031257
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Ito, J
   Nakagawa, K
   Kato, S
   Miyazawa, T
   Kimura, F
   Miyazawa, T
AF Ito, Junya
   Nakagawa, Kiyotaka
   Kato, Shunji
   Miyazawa, Taiki
   Kimura, Fumiko
   Miyazawa, Teruo
TI The combination of maternal and offspring high-fat diets causes marked
   oxidative stress and development of metabolic syndrome in mouse
   offspring
SO LIFE SCIENCES
LA English
DT Article
DE PCOOH; Oxidative stress; Fetal programming model; Gpx4; Metabolic
   syndrome
ID HYDROPEROXIDE GLUTATHIONE-PEROXIDASE; LIPID-PEROXIDATION;
   PHOSPHATIDYLCHOLINE HYDROPEROXIDE; LIQUID-CHROMATOGRAPHY;
   GENE-EXPRESSION; HUMAN PLASMA; ACID; MICE; RATS; AGE
AB Maternal overnutrition (e.g., high-fat (HF) diet) during pregnancy and lactation is believed to cause oxidative stress and increase the risk of metabolic syndrome in offspring. In the present study, we investigated the effects of both maternal and offspring HF diets on metabolic syndrome risk and oxidative stress profiles in mice. Dams of the C57BL/6J mouse strain were fed a HF or control (CO) diet during gestation and lactation. Offspring were weaned at 3 weeks of age. The female offspring were sacrificed at weaning, while the males were maintained on the HF or CO diet until 11 weeks of age. Tissue samples, including those from liver, were collected from offspring at 3 and 11 weeks of age, and lipids, phosphatidylcholine hydroperoxide (PCOOH, an oxidative stress marker), and gene expression were evaluated. Accumulation of lipids, but not PCOOH, was found in the livers of 3-week-old offspring from dams fed the HF diet. When the offspring were maintained on a HF diet until 11 weeks of age, marked accumulation of both liver lipids and PCOOH was observed. PCOOH manifestation was supported by the expression of genes such as Gpx4, encoding a PCOOH degrading enzyme. These results suggest that the combination of maternal and offspring overnutrition causes marked oxidative stress in offspring, which accelerates metabolic syndrome. The present findings in offspring from infancy to adulthood may be useful for better understanding the cause-and-effect relationships between oxidative stress and metabolic syndrome development. (C) 2016 Elsevier Inc. All rights reserved.
C1 [Ito, Junya; Nakagawa, Kiyotaka; Kimura, Fumiko; Miyazawa, Teruo] Tohoku Univ, Grad Sch Agr Sci, Food & Biodynam Chem Lab, Sendai, Miyagi 9818555, Japan.
   [Kato, Shunji] Nippon Med Sch, Dept Med, Div Endocrinol & Metab, Tokyo 1138603, Japan.
   [Miyazawa, Taiki] Tufts Univ, Vasc Biol Lab, Jean Mayer USDA Human Nutr Res Ctr Aging, Boston, MA 02111 USA.
C3 Tohoku University; Nippon Medical School; United States Department of
   Agriculture (USDA); Tufts University
RP Nakagawa, K (corresponding author), Tohoku Univ, Grad Sch Agr Sci, Food & Biodynam Chem Lab, Aoba Ku, 1-1 Tsutsumidori Amamiyamachi, Sendai, Miyagi 9818555, Japan.
EM nkgw@m.tohoku.ac.jp
RI Kato, Shunji/ABG-8440-2021; Ito, Junya/KPA-7635-2024; Miyazawa,
   Taiki/G-5994-2014
OI Kato, Shunji/0000-0003-4659-9541; Ito, Junya/0000-0001-9190-4969;
   Miyazawa, Taiki/0000-0002-8937-5110
FU Grants-in-Aid for Scientific Research [15H04497, 13J06103] Funding
   Source: KAKEN
CR Angulo P, 2002, NEW ENGL J MED, V346, P1221, DOI 10.1038/nrdp.2015.80
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NR 33
TC 30
Z9 30
U1 0
U2 6
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0024-3205
EI 1879-0631
J9 LIFE SCI
JI Life Sci.
PD APR 15
PY 2016
VL 151
BP 70
EP 75
DI 10.1016/j.lfs.2016.02.089
PG 6
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA DL6DK
UT WOS:000375728400009
PM 26924496
DA 2025-06-11
ER

PT J
AU Wang, W
   Zhao, S
   Zhou, R
   Yu, PZ
   Pan, SY
   Huan, PF
   Shi, ZD
   Liu, Y
   Hu, X
   Lu, JR
   Han, CH
AF Wang, Wei
   Zhao, Shuai
   Zhou, Ran
   Yu, Pei-Ze
   Pan, Si-Yuan
   Huan, Peng-Fei
   Shi, Zhen-Duo
   Liu, Ying
   Hu, Xiao
   Lu, Jing-Ru
   Han, Conghui
TI Associations between metabolic syndrome and erectile dysfunction:
   evidence from the NHANES 2001-2004
SO FRONTIERS IN PUBLIC HEALTH
LA English
DT Article
DE metabolic syndrome; erectile dysfunction; NHANES; prevalence;
   cross-sectional study
ID UNITED-STATES; MEN; PREVALENCE; HEALTH
AB Background and objectives Erectile dysfunction is a common clinical condition that seriously affects the quality of life and mental health of men and their partners. Metabolic syndrome (MetS) is the most important public health problem threatening men's health worldwide, and its current prevalence continues to grow. This study examines the relationship between metabolic syndrome and erectile dysfunction (ED). Method We conducted a cross-sectional study with data were sourced from NHANES 2001-2004. In this study, the relationship between METS-VF and ED was analyzed using multivariate logistic regression, followed by subgroup analyses to identify sensitive populations. Comparative logistic regression of the Receiver Operating Characteristic (ROC) curve assessed the diagnostic capability of METS-VF against the classical obesity index for ED. Creating Predictive Histograms for ED Patients and assess the net benefit of the model through Decision Curve Analysis (DCA). Results The study enrolled 1,374 participants, of whom 545 self-reported ED history. There was a significant positive association between metabolic syndrome and erectile dysfunction (ED). The risk of ED in people with metabolic syndrome was 2.32 times higher than that in people without metabolic syndrome (dominance ratio = 2.32, 95% confidence interval: 1.83-2.96, p < 0.001). Subgroup analysis highlighted a stronger correlation in participants aged 50-85 years, hypertensive individuals, and those with large belly circumference. A histogram model including three variables: metabolic syndrome, age and smoking status was constructed to predict the probability of ED occurrence. And decision curve analysis (DCA) was used to assess the net benefit of its nomogram model at different high-risk thresholds. The high clinical utility of the model under different thresholds was illustrated. Conclusion The risk of ED in people with metabolic syndrome was 2.32 times higher than that in people without metabolic syndrome. Furthermore, this observed positive correlation emphasizes the need for increased vigilance in patients with advanced age, smoking, and MetS.
C1 [Wang, Wei; Han, Conghui] Southeast Univ, Sch Med, Nanjing, Peoples R China.
   [Wang, Wei; Zhou, Ran; Yu, Pei-Ze; Pan, Si-Yuan; Huan, Peng-Fei; Shi, Zhen-Duo] Xuzhou Cent Hosp, Dept Urol, Xuzhou, Peoples R China.
   [Zhao, Shuai] China RongTong Med Healthcare Grp Co Ltd, Dept Urol, Zibo Hosp 148, Zibo, Peoples R China.
   [Zhou, Ran; Yu, Pei-Ze; Pan, Si-Yuan] Xuzhou Med Univ, Sch Med, Xuzhou, Peoples R China.
   [Liu, Ying; Hu, Xiao] Xuzhou Cent Hosp, Dept Cent Lab, Xuzhou, Peoples R China.
   [Lu, Jing-Ru] Shandong First Med Univ, Shandong Prov Hosp, Dept Nephrol, Jinan, Peoples R China.
C3 Southeast University - China; Xuzhou Medical University; Shandong First
   Medical University & Shandong Academy of Medical Sciences
RP Han, CH (corresponding author), Southeast Univ, Sch Med, Nanjing, Peoples R China.; Lu, JR (corresponding author), Shandong First Med Univ, Shandong Prov Hosp, Dept Nephrol, Jinan, Peoples R China.
EM 751418853@qq.com; hanconghuidoctor@vip.qq.com
RI Pan, Siyuan/HJY-5890-2023
FU Xuzhou City 2022 Special Program for Promoting Science and Technology
   Innovation [KC22096]; Shandong Provincial Hospital Research Incubation
   Fund [2022FY063]
FX The author(s) declare that financial support was received for the
   research and/or publication of this article. This study was supported by
   the Xuzhou City 2022 Special Program for Promoting Science and
   Technology Innovation (Grant No. KC22096) and Shandong Provincial
   Hospital Research Incubation Fund (No: 2022FY063).
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NR 39
TC 0
Z9 0
U1 9
U2 9
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 2296-2565
J9 FRONT PUBLIC HEALTH
JI Front. Public Health
PD MAR 18
PY 2025
VL 13
AR 1543668
DI 10.3389/fpubh.2025.1543668
PG 10
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA 0UZ9J
UT WOS:001456668600001
PM 40171419
OA gold
DA 2025-06-11
ER

PT J
AU Fornari, E
   Maffeis, C
AF Fornari, Elena
   Maffeis, Claudio
TI Treatment of Metabolic Syndrome in Children
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Review
DE obesity; treatment; children; adolescents; metabolic syndrome
ID CARDIOVASCULAR RISK-FACTORS; FATTY LIVER-DISEASE; BODY-MASS INDEX;
   IMPAIRED GLUCOSE-TOLERANCE; OBESE WHITE-CHILDREN; PHYSICAL-ACTIVITY;
   BLOOD-PRESSURE; WEIGHT-LOSS; PEDIATRIC OBESITY; INSULIN-RESISTANCE
AB The Metabolic Syndromemay be tentatively defined as the clustering of several metabolic risk factors in the same individual. A progressively higher number of children and adolescents is affected by this syndrome worldwide, mainly as a consequence of the constant increase of the prevalence of obesity and sedentary habits. As obesity, the chance that the metabolic syndrome traks into adulthood is high. Moreover, the evidence of an association between the duration of the exposition to metabolic risk factors and morbidity and mortality justifies early treatment and prevention of themetabolic syndrome in both children and adolescents. Treatment includes behavioral interventions, adequate nutrition and physical activity, and, if necessary, pharmacological treatments aimed at reducing excessive weight, dyslipidemia, hypertension, and glucose impairments. A multidisciplinary and staged approach to treatment, which includes pediatrician, mental health practitioner, dietician, and nurses, is crucial. Usually, the reduction of fat mass promotes an overall improvement of all the components of the metabolic syndrome. Nevertheless, every single component of the metabolic syndrome should be treated as quickly as possible, by using the best current practice. Drugs may be necessary for treating hypertension, type 2 diabetes mellitus and dyslipidemia. In selected cases of gross obesity resistant to treatment, surgical therapy may be also performed.
C1 [Fornari, Elena; Maffeis, Claudio] Univ Verona, Pediat Diabet & Metab Disorders Unit, Dept Surg Sci Dent & Pediat & Gynecol, Verona, Italy.
C3 University of Verona
RP Maffeis, C (corresponding author), Univ Verona, Pediat Diabet & Metab Disorders Unit, Dept Surg Sci Dent & Pediat & Gynecol, Verona, Italy.
EM claudio.maffeis@univr.it
RI Maffeis, Claudio/AAG-5347-2020
FU FURMAFF, Department of Surgical Sciences, Dentistry, Paediatrics, and
   Gynaecology, University of Verona
FX This work was supported by the FURMAFF, Department of Surgical Sciences,
   Dentistry, Paediatrics, and Gynaecology, University of Verona.
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NR 91
TC 28
Z9 28
U1 1
U2 21
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD OCT 15
PY 2019
VL 10
AR 702
DI 10.3389/fendo.2019.00702
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA JO3AV
UT WOS:000497454600001
PM 31681173
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Han, GM
   Soliman, GA
   Meza, JL
   Islam, KMM
   Watanabe-Galloway, S
AF Han, Guang-Ming
   Soliman, Ghada A.
   Meza, Jane L.
   Islam, K. M. Monirul
   Watanabe-Galloway, Shinobu
TI The influence of BMI on the association between serum lycopene and the
   metabolic syndrome
SO BRITISH JOURNAL OF NUTRITION
LA English
DT Article
DE Overweight; Obesity; Antioxidant; Oxidative stress; Carotenoids;
   Physical activity
ID OXIDATIVE STRESS; CAROTENOID CONCENTRATIONS; ANTIOXIDANT ENZYMES; LOWER
   PREVALENCE; DIETARY; OBESITY; RISK; CONSUMPTION; OVERWEIGHT; IMPACT
AB Overweight and obese individuals have an increased risk of developing the metabolic syndrome because of subsequent chronic inflammation and oxidative stress, which the antioxidant nutrient lycopene can reduce. However, studies indicate that different BMI statuses can alter the positive effects of lycopene. Therefore, the purpose of this study was to examine how BMI influences the association between serum lycopene and the metabolic syndrome. The tertile rank method was used to divide 13 196 participants, aged 20 years and older, into three groups according to serum concentrations of lycopene. The associations between serum lycopene and the metabolic syndrome were analysed separately for normal-weight, overweight and obese participants. Overall, the prevalence of the metabolic syndrome was significantly higher in the first tertile group (OR 386 %; 95 % CI 369, 403) compared with the second tertile group (OR 293 %; 95 % CI 275, 311) and the third tertile group (OR 266 %; 95 % CI 249, 283). However, the associations between lycopene and the metabolic syndrome were only significant for normal-weight and overweight participants (P<005), but not for obese participants (P>005), even after adjusting for possible confounding variables. In conclusion, BMI appears to strongly influence the association between serum lycopene and the metabolic syndrome.
C1 [Han, Guang-Ming; Islam, K. M. Monirul; Watanabe-Galloway, Shinobu] Univ Nebraska Med Ctr, Coll Publ Hlth, Dept Epidemiol, Omaha, NE 68198 USA.
   [Soliman, Ghada A.] Univ Nebraska Med Ctr, Coll Publ Hlth, Dept Hlth Promot Social & Behav Hlth, Omaha, NE 68198 USA.
   [Meza, Jane L.] Univ Nebraska Med Ctr, Coll Publ Hlth, Dept Biostat, Omaha, NE 68198 USA.
C3 University of Nebraska System; University of Nebraska Medical Center;
   University of Nebraska System; University of Nebraska Medical Center;
   University of Nebraska System; University of Nebraska Medical Center
RP Watanabe-Galloway, S (corresponding author), Univ Nebraska Med Ctr, Coll Publ Hlth, Dept Epidemiol, Omaha, NE 68198 USA.
EM swatanabe@unmc.edu
RI Han, Guang-Ming/C-6500-2017; Soliman, Ghada/U-6472-2017
OI Han, Guang-Ming/0000-0001-8901-5222; Soliman, Ghada/0000-0002-8629-6062
FU NCI NIH HHS [R25 CA112383] Funding Source: Medline; NIDDK NIH HHS [K01
   DK060654] Funding Source: Medline
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NR 39
TC 20
Z9 20
U1 0
U2 10
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1145
EI 1475-2662
J9 BRIT J NUTR
JI Br. J. Nutr.
PD APR 14
PY 2016
VL 115
IS 7
BP 1292
EP 1300
DI 10.1017/S0007114516000179
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA DH6BW
UT WOS:000372877000016
PM 26857614
OA Bronze
DA 2025-06-11
ER

PT J
AU On-Nom, N
   Suttisansanee, U
   Tongmai, J
   Khemthong, C
   Chamchan, R
   Prangthip, P
   Hanboonkunupakarn, B
   Chupeerach, C
AF On-Nom, Nattira
   Suttisansanee, Uthaiwan
   Tongmai, Jutamas
   Khemthong, Chanakan
   Chamchan, Rungrat
   Prangthip, Pattaneeya
   Hanboonkunupakarn, Borimas
   Chupeerach, Chaowanee
TI Consumption of Anthocyanin-Rich Mulberry Fruit Jelly with a High-Fat
   Meal Decreases Postprandial Serum Cardiometabolic Risk Factors in
   Dyslipidemia Subjects
SO JOURNAL OF NUTRITION AND METABOLISM
LA English
DT Article
ID ANTIOXIDANT ACTIVITIES; CHEMICAL-COMPOSITION; INSULIN-RESISTANCE;
   OXIDATIVE STRESS; HYPERGLYCEMIA; CHOLESTEROL; OVERWEIGHT; CULTIVARS;
   CAPACITY; EXTRACT
AB Anthocyanin content in berries has been reported to promote antioxidant properties that mitigate the occurrence of noncommunicable diseases. However, only a few studies have investigated the benefits of anthocyanin-rich food products from mulberry fruit to reduce the cardiometabolic risk factor in dyslipidemia subjects. Anthocyanin-rich mulberry fruit jelly was formulated using mulberry fruit powder (MFP), and its activities on serum cardiometabolic risk factors in dyslipidemia subjects were studied. Morus alba var. Chiang Mai was used as the ingredient for MFP jelly containing 14 g MFP (191 mg anthocyanin) per serving size (170 g). To investigate the effect of MFP jelly on reduction of cardiometabolic risk factors, sixteen dyslipidemia subjects were given one serving of MFP jelly every day for seven days. After MFP jelly intervention, fasting blood cholesterol, low-density lipoprotein (LDL), and inflammatory markers including interleukin-6 levels of the subjects were significantly lower. Postprandial blood parameters were measured at 0-240 min after consuming a high-fat meal before and after MFP jelly intervention. Postprandial blood glucose at 30 min (p<0.05) and insulin at 60 and 90 min (p<0.01) were lower in MFP than in placebo jelly. The area under the curve of insulin in MFP jelly was smaller than in placebo by 31.2%. Therefore, MFP jelly intervention increased insulin sensitivity. For antioxidant activity markers, postprandial oxygen radical absorbance capacity after MFP jelly intervention gave a smaller decrease after high-fat meal intake compared to after placebo jelly intervention. Moreover, for the oxidative stress markers, postprandial malondialdehyde level was significantly lower in MFP jelly. Seven days of intervention by one serving size of MFP jelly containing 191 mg of anthocyanins reduced cardiometabolic risk factors by lowering blood total cholesterol, LDL, and inflammation, and improving insulin sensitivity and postprandial blood antioxidant-oxidative stress activity in dyslipidemia subjects. This trial is registered with.
C1 [On-Nom, Nattira; Suttisansanee, Uthaiwan; Tongmai, Jutamas; Khemthong, Chanakan; Chamchan, Rungrat; Chupeerach, Chaowanee] Mahidol Univ, Inst Nutr, 999 Phutthamonthon 4 Rd, Phutthamonthon 73170, Nakhon Pathom, Thailand.
   [Prangthip, Pattaneeya] Mahidol Univ, Fac Trop Med, Dept Trop Nutr & Food Sci, 420-6 Ratchawithi Rd, Bangkok 10400, Thailand.
   [Hanboonkunupakarn, Borimas] Mahidol Univ, Fac Trop Med, Dept Clin Trop Med, 420-6 Ratchawithi Rd, Bangkok 10400, Thailand.
C3 Mahidol University; Mahidol University; Mahidol University
RP Chupeerach, C (corresponding author), Mahidol Univ, Inst Nutr, 999 Phutthamonthon 4 Rd, Phutthamonthon 73170, Nakhon Pathom, Thailand.
EM nattira.onn@mahidol.ac.th; uthaiwan.sut@mahidol.ac.th;
   thong.jutha@gmail.com; baitoey_chanakan@outlook.com;
   rungrat.cha@mahidol.ac.th; pattaneeya.pra@mahidol.ac.th;
   borimas.han@mahidol.ac.th; chaowanee.chu@mahidol.ac.th
RI Suttisansanee, Uthaiwan/JCE-4100-2023
OI Chupeerach, Chaowanee/0000-0002-1093-1621; Suttisansanee,
   Uthaiwan/0000-0001-5887-6329; Prangthip, Pattaneeya/0000-0002-0316-9528
FU Mahidol University; National Research Council of Thailand (NRCT)
FX This research project was supported by Mahidol University and the
   National Research Council of Thailand (NRCT). The authors would like to
   thank all volunteers to the willing cooperation.
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NR 46
TC 7
Z9 7
U1 4
U2 12
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2090-0724
EI 2090-0732
J9 J NUTR METAB
JI J. Nutr. Metab.
PD JUL 9
PY 2020
VL 2020
AR 1370951
DI 10.1155/2020/1370951
PG 9
WC Nutrition & Dietetics
WE Emerging Sources Citation Index (ESCI)
SC Nutrition & Dietetics
GA MY6YB
UT WOS:000558559000001
OA gold
DA 2025-06-11
ER

PT J
AU Siqueira, JS
   Nakandakare-Maia, ET
   Vieira, TA
   Palacio, TLN
   Belin, MAF
   Baron, G
   Bazan, SGZ
   Ferron, AJT
   Aldini, G
   Francisqueti-Ferron, FV
   Correa, CR
AF Siqueira, Juliana Silva
   Nakandakare-Maia, Erika Tiemi
   Vieira, Taynara Aparecida
   Palacio, Thiago Luiz Novaga
   Belin, Matheus Antonio Filiol
   Baron, Giovanna
   Bazan, Silmeia Garcia Zanati
   Ferron, Artur Junio Togneri
   Aldini, Giancarlo
   Francisqueti-Ferron, Fabiane Valentini
   Correa, Camila Renata
TI Overview of bergamot leaves extract (Citrus bergamia)
   effect on the RedOx/ Inflammatory scenario in obesity target organs in
   an animal model of metabolic syndrome
SO JOURNAL OF FUNCTIONAL FOODS
LA English
DT Article
DE Bioactive compound; Inflammation; Oxidative stress; Western diet
ID OXIDATIVE STRESS; INSULIN-RESISTANCE; ADIPOSE-TISSUE; POITEAU JUICE;
   ANTIOXIDANT; DYSFUNCTION; RISSO; MICE
AB Bergamot (Citrus bergamia) is a fruit with anti-inflammatory and antioxidant properties that contains similar bioactive composition to its leaf, evidencing its therapeutic potential in the treatment of chronic diseases. The aim was to evaluate the treatment effect of bergamot leaf extract (BLE) on the redox/inflammatory scenario in different organs of obese rats with metabolic syndrome. After detection of metabolic syndrome, male Wistar rats were allocated (n = 10/group) for the treatment with BLE by gavage (50 mg/kg): Control, Control+BLE, High Sugar fat (HSF), and HSF+BLE. Evaluations included: metabolic -nutritional profile; tissues function and redox/ inflammatory parameters. The HSF group presented metabolic syndrome, cardiac, hepatic and renal dysfunction; inflammation; and oxidative stress. BLE decreased oxidative stress and inflammation levels in adipose tissue, heart, liver and kidneys, as well as decreased levels of triglycerides, insulin and insulin resistance. BLE act in all target organs of obesity, improving the redox/inflammatory scenario in a diet -induced metabolic syndrome.
C1 [Siqueira, Juliana Silva; Nakandakare-Maia, Erika Tiemi; Vieira, Taynara Aparecida; Palacio, Thiago Luiz Novaga; Belin, Matheus Antonio Filiol; Bazan, Silmeia Garcia Zanati; Francisqueti-Ferron, Fabiane Valentini; Correa, Camila Renata] Sao Paulo State Univ Unesp, Med Sch, BR-18618687 Botucatu, Brazil.
   [Baron, Giovanna; Aldini, Giancarlo] Univ Milan, Dept Pharmaceut Sci, I-20133 Milan, Italy.
   [Ferron, Artur Junio Togneri; Francisqueti-Ferron, Fabiane Valentini] Integrated Coll Bauru FIB, BR-17056100 Bauru, Brazil.
   [Siqueira, Juliana Silva] Sao Paulo State Univ Unesp, Botucatu Med Sch, Prof Montenegro Ave, BR-18618687 Botucatu, Brazil.
C3 Universidade Estadual Paulista; University of Milan; Universidade
   Estadual Paulista
RP Siqueira, JS (corresponding author), Sao Paulo State Univ Unesp, Botucatu Med Sch, Prof Montenegro Ave, BR-18618687 Botucatu, Brazil.
EM juliana.siqueira@unesp.br
RI Francisqueti-Ferron, Fabiane/M-4919-2017; Zanati-Bazan,
   Silmeia/F-3177-2012; Baron, Giovanna/ABE-3121-2020; aldini,
   giancarlo/C-3533-2013; Ferron, Artur/M-5194-2017; Siqueira,
   Juliana/AAR-7994-2021; Belin, Matheus/AAG-5163-2019; Correa,
   Camila/Q-2071-2019; Novaga Palacio, Thiago Luiz/AGP-5802-2022; Aparecida
   Vieira, Taynara/JFK-7958-2023
OI Baron, Giovanna/0000-0002-9335-6318; aldini,
   giancarlo/0000-0002-2355-6744; Filiol Belin, Matheus
   Antonio/0000-0002-1656-405X; Correa, Camila Renata/0000-0001-8493-5329;
   Novaga Palacio, Thiago Luiz/0000-0001-9568-7156; Aparecida Vieira,
   Taynara/0000-0002-5312-0060
FU Sao Paulo Research Foundation (FAPESP) [2021/13050-2, 2021/07282-8]
FX Funding. This work was supported by the Sao Paulo Research Foundation
   (FAPESP) [2021/13050-2; 2021/07282-8] .
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NR 69
TC 2
Z9 2
U1 0
U2 4
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1756-4646
EI 2214-9414
J9 J FUNCT FOODS
JI J. Funct. Food.
PD FEB
PY 2024
VL 113
AR 106042
DI 10.1016/j.jff.2024.106042
EA FEB 2024
PG 9
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA KA3I9
UT WOS:001177197900001
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Lundström, S
   Jormfeldt, H
   Ahlström, BH
   Skärsäter, I
AF Lundstrom, Sofie
   Jormfeldt, Henrika
   Ahlstrom, Britt Hedman
   Skarsater, Ingela
TI Mental health nurses' experience of physical health care and health
   promotion initiatives for people with severe mental illness
SO INTERNATIONAL JOURNAL OF MENTAL HEALTH NURSING
LA English
DT Article
DE health promotion; lifestyle; mental health nursing; person-centred care;
   severe mental illness
ID QUALITATIVE CONTENT-ANALYSIS; METABOLIC SYNDROME; SCHIZOPHRENIA;
   MORTALITY; VIEWS
AB Health care for people with severe mental illness is often divided into physical health care and mental health care despite the importance of a holistic approach to caring for the whole person. Mental health nurses have an important role not only in preventing ill health, but also in promoting health, to improve the overall health among people with severe mental illness and to develop a more person-centred, integrated physical and mental health care. Thus, the aim of this study was to describe mental health nurses' experiences of facilitating aspects that promote physical health and support a healthy lifestyle for people with severe mental illness. Interviews were conducted with mental health nurses (n = 15), and a qualitative content analysis was used to capture the nurse's experiences. Analysis of the interviews generated three categories: (i) to have a health promotion focus in every encounter, (ii) to support with each person's unique prerequisites in mind and (iii) to take responsibility for health promotion in every level of the organization. The results show the importance of a health promotion focus that permeates the entire organization of mental health care. Shared responsibility for health and health promotion activities should exist at all levels: in the person-centred care in the relation with the patient, embedded in a joint vision within the working unit, and in decisions at management level.
C1 [Lundstrom, Sofie; Jormfeldt, Henrika; Skarsater, Ingela] Halmstad Univ, Sch Hlth & Welf, Kristians IV S Vag 3, S-30118 Halmstad, Sweden.
   [Ahlstrom, Britt Hedman] Univ West, Dept Hlth Sci, Trollhattan, Sweden.
C3 Halmstad University; University West - Sweden
RP Lundström, S (corresponding author), Halmstad Univ, Sch Hlth & Welf, Kristians IV S Vag 3, S-30118 Halmstad, Sweden.
EM sofie.lundstrom@hh.se
RI Ahlström, Britt/Y-8217-2019
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NR 36
TC 15
Z9 16
U1 1
U2 21
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1445-8330
EI 1447-0349
J9 INT J MENT HEALTH NU
JI Int. J. Ment. Health Nurs.
PD APR
PY 2020
VL 29
IS 2
BP 244
EP 253
DI 10.1111/inm.12669
PG 10
WC Nursing; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Psychiatry
GA KT6RE
UT WOS:000519140700013
PM 31663262
DA 2025-06-11
ER

PT J
AU McIntyre, RS
   Rasgon, NL
   Kemp, DE
   Nguyen, HT
   Law, CWY
   Taylor, VH
   Woldeyohannes, HO
   Alsuwaidan, MT
   Soczynska, JK
   Kim, B
   Lourenco, MT
   Kahn, LS
   Goldstein, BI
AF McIntyre, Roger S.
   Rasgon, Natalie L.
   Kemp, David E.
   Nguyen, Ha T.
   Law, Candy W. Y.
   Taylor, Valerie H.
   Woldeyohannes, Hanna O.
   Alsuwaidan, Mohammad T.
   Soczynska, Joanna K.
   Kim, Byungsu
   Lourenco, Maria T.
   Kahn, Linda S.
   Goldstein, Benjamin I.
TI Metabolic syndrome and major depressive disorder: Co-occurrence and
   pathophysiologic overlap
SO CURRENT DIABETES REPORTS
LA English
DT Article
ID AUTONOMIC NERVOUS-SYSTEM; BODY-FAT DISTRIBUTION; BIPOLAR-DISORDER;
   ANTIDEPRESSANT TREATMENT; CARDIOVASCULAR-DISEASE; INSULIN-RESISTANCE;
   OXIDATIVE STRESS; BLOOD-PRESSURE; RISK; PREVALENCE
AB The metabolic syndrome and its components are associated with depressive symptomatology. This article discusses the rate of co-occurrence and the points of pathophysiologic commonality between the metabolic syndrome and major depressive disorder.
C1 [McIntyre, Roger S.] Univ Hlth Network, Mood Disorders Psychopharmacol Unit, Toronto, ON M5T 2S8, Canada.
C3 University of Toronto; University Health Network Toronto
RP McIntyre, RS (corresponding author), Univ Hlth Network, Mood Disorders Psychopharmacol Unit, 399 Bathurst St, Toronto, ON M5T 2S8, Canada.
EM roger.mcintyre@uhn.on.ca
RI Rasgon, Natalie/ABH-9813-2020; Kim, Byungsu/JNE-3151-2023; Lourenco,
   Maria/C-3525-2017; Goldstein, Benjamin/ADR-2374-2022; McIntyre,
   Roger/AAU-1000-2020; Huy, Nguyen Tien/B-2573-2010; Taylor,
   Valerie/H-6242-2015
OI Taylor, Valerie/0000-0002-8948-638X; Soczynska,
   Joanna/0000-0003-0003-7164; Alsuwaidan, Mohammad/0000-0003-1344-2935
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NR 58
TC 105
Z9 113
U1 0
U2 18
PU CURRENT MEDICINE GROUP
PI PHILADELPHIA
PA 400 MARKET STREET, STE 700, PHILADELPHIA, PA 19106 USA
SN 1534-4827
EI 1539-0829
J9 CURR DIABETES REP
JI Curr. Diabetes Rep.
PD FEB
PY 2009
VL 9
IS 1
BP 51
EP 59
DI 10.1007/s11892-009-0010-0
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 409AI
UT WOS:000263478200007
PM 19192425
DA 2025-06-11
ER

PT J
AU Sentí, M
   Tomás, M
   Fitó, M
   Weinbrenner, T
   Covas, MI
   Sala, J
   Masiá, R
   Marrugat, J
AF Sentí, M
   Tomás, M
   Fitó, M
   Weinbrenner, T
   Covas, MI
   Sala, J
   Masiá, R
   Marrugat, J
TI Antioxidant paraoxonase 1 activity in the metabolic syndrome
SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Article
ID LOW-DENSITY-LIPOPROTEIN; SERUM PARAOXONASE; INSULIN-RESISTANCE;
   OXIDATIVE STRESS; PEROXIDATION; CHOLESTEROL; PREVALENCE; PROTECTION;
   VARIANTS; PLASMA
AB Paraoxonase (PON1) is an antioxidant enzyme closely associated with high-density lipoproteins. Low PON1 has been shown in oxidative stress-associated processes such as dyslipidemia, diabetes mellitus, advancing age, and smoking. Indeed, oxidative stress is related to the degree of insulin resistance, a key component of the metabolic syndrome. Therefore, the possible relationship between PON1 activity and the metabolic syndrome was investigated.
   From 1364 randomly recruited subjects, 285 were found to have the metabolic syndrome, according to the guidelines published by the National Cholesterol Education Program, Adult Treatment Panel III. PON1 activity, lipid peroxides, and PON1 codon 192 genotypes, which strongly modulate PON1 activity, were determined.
   Serum PON1 activity levels were found to be significantly lower, and lipid peroxide concentrations significantly higher, in subjects with the metabolic syndrome compared with unaffected subjects ( P = 0.033 and < 0.001, respectively). Study subjects showed a significant decreasing trend in PON1 activity levels and a significant increasing trend in lipid peroxide concentrations, with the increase in the number of metabolic disturbances. No differences in the prevalence of PON1 codon 192 genotypes were found among the categories of metabolic abnormalities.
   In conclusion, a greater degree of severity of the metabolic syndrome is associated with a progressively worse antioxidant/ oxidant balance, which is consistent with increased oxidative stress and lower antioxidant PON1 enzymatic capacity.
C1 Inst Municipal Invest Med, Lipids & Cardiovasc Epidemiol Unit, E-08003 Barcelona, Spain.
   Hosp Josep Trueta, Girona 17007, Spain.
   Univ Pompeu Fabra, Barcelona, Spain.
C3 Universitat de Girona; Girona University Hospital Dr. Josep Trueta;
   Pompeu Fabra University
EM msenti@imim.es
RI Senti, M/D-4309-2014; Fito Colomer, Montse/C-1822-2012
OI Senti, Mariano/0000-0002-6983-3831; Fito Colomer,
   Montse/0000-0002-1817-483X; Marrugat, Jaume/0000-0003-3320-554X
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NR 36
TC 129
Z9 141
U1 0
U2 1
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0021-972X
EI 1945-7197
J9 J CLIN ENDOCR METAB
JI J. Clin. Endocrinol. Metab.
PD NOV 1
PY 2003
VL 88
IS 11
BP 5422
EP 5426
DI 10.1210/jc.2003-030648
PG 5
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 740GD
UT WOS:000186393900056
PM 14602783
DA 2025-06-11
ER

PT J
AU Demiral, Y
   Soysal, A
   Bilgini, AC
   Kiliç, B
   Unal, B
   Uçku, R
   Theorell, T
AF Demiral, Yucel
   Soysal, Ahmet
   Bilgini, Ahmet Can
   Kilic, Bulent
   Unal, Belgin
   Ucku, Reyhan
   Theorell, Tores
TI The association of job strain with coronary heart disease and metabolic
   syndrome in municipal workers in Turkey
SO JOURNAL OF OCCUPATIONAL HEALTH
LA English
DT Article
DE job strain; coronary heart disease; metabolic syndrome
ID CARDIOVASCULAR-DISEASE; MYOCARDIAL-INFARCTION; STRESS MODELS; RISK;
   HEALTH; ENVIRONMENT; PREVALENCE
AB Turkey-To explore the association of job strain with CHD and metabolic syndrome in municipal workers. A cross-sectional study was completed of 450 male workers. Coronary heart disease was defined as: physician diagnosed ischemic heart disease; and/or, ischemic findings in the ECG. Metabolic syndrome was defined according to the criterion set by the National Cholesterol Education Panel. The demand-control model was used to assess job strain. Self administered questionnaires were completed after a face to face interview. Logistic regression models were constructed to assess the association of job strain with CHD and metabolic syndrome. The prevalence of metabolic syndrome and CHD were 17.8% and 8.0% respectively. Both CHD and metabolic syndrome were found to be significantly higher in higher income groups. Job demand and job control were not found to be associated with either CHD or metabolic syndrome. Metabolic syndrome was significantly more prevalent among the high job strain workers, but the significance was lost when controlled for age. The findings suggest that there is no significant association between job strain and metabolic syndrome and CHD in this sample of Turkish workers. Job strain may possibly be perceived differently in different cultures and occupations. Future studies may benefit from using a combination of different stress models and more diverse study populations.
C1 Dokuz Eylul Univ, Sch Med, Dept Publ Hlth, TR-35340 Izmir, Turkey.
C3 Dokuz Eylul University
RP Demiral, Y (corresponding author), Dokuz Eylul Univ, Sch Med, Dept Publ Hlth, TR-35340 Izmir, Turkey.
EM yucel.demiral@deu.edu.tr
RI Demiral, Yucel/AAP-3351-2020; ucku, reyhan/JCF-1622-2023; Kılıç,
   Bülent/Q-2078-2019; Unal, Belgin/E-7064-2017
OI SOYSAL, AHMET/0000-0003-4711-7049; Unal, Belgin/0000-0002-4354-8266;
   Demiral, Yucel/0000-0002-4281-0218
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NR 29
TC 28
Z9 29
U1 4
U2 15
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1341-9145
EI 1348-9585
J9 J OCCUP HEALTH
JI J. Occup. Health
PD SEP
PY 2006
VL 48
IS 5
BP 332
EP 338
DI 10.1539/joh.48.332
PG 7
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA 097JH
UT WOS:000241442900004
PM 17053299
OA Bronze
DA 2025-06-11
ER

PT J
AU Lambert, JLW
   Segaert, S
   Ghislain, PD
   Hillary, T
   Nikkels, A
   Willaert, F
   Lambert, J
   Speeckaert, R
AF Lambert, J. L. W.
   Segaert, S.
   Ghislain, P. D.
   Hillary, T.
   Nikkels, A.
   Willaert, F.
   Lambert, J.
   Speeckaert, R.
TI Practical recommendations for systemic treatment in psoriasis according
   to age, pregnancy, metabolic syndrome, mental health, psoriasis subtype
   and treatment history (BETA-PSO: Belgian Evidence-based Treatment Advice
   in Psoriasis; part 1)
SO JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
LA English
DT Article
ID GENERALIZED PUSTULAR PSORIASIS; SEVERE PLAQUE PSORIASIS; FACTOR-ALPHA
   INHIBITORS; FUMARIC-ACID ESTERS; LONG-TERM SAFETY; ERYTHRODERMIC
   PSORIASIS; LIVER-INJURY; DEPRESSIVE SYMPTOMS; BIOLOGIC THERAPY; NAIL
   PSORIASIS
AB Background Impressive progress in new therapeutic options has been made for psoriasis. Treatments include topical steroids, phototherapy, conventional, synthetic disease-modifying drugs and an expanding list of biologics. Objective The primary objective of this work was to collect evidence for the creation of practice guidelines for systemic treatment of psoriasis (BETA-PSO: Belgian Evidence-based Treatment Advice in Psoriasis). Methods Evidence-based recommendations were formulated using a quasi-Delphi methodology after a systematic search of the literature and a consensus procedure involving 8 psoriasis experts. Results In this part, the use of systemic treatment in different age groups, during pregnancy, in metabolic syndrome, in patients with mental health problems, in different psoriasis subtypes and in previously systemically treated patients treatment is discussed. Conclusion Guidance on therapeutic choice in specific clinical situations in psoriasis is provided in order to facilitate the decision-making in clinical practice.
C1 [Lambert, J. L. W.; Speeckaert, R.] Ghent Univ Hosp, Dept Dermatol, Ghent, Belgium.
   [Segaert, S.] Private practice, Tremelo, Belgium.
   [Ghislain, P. D.] Catholic Univ Louvain, Dermatol, Clin St, Luc, Brussels, Belgium.
   [Hillary, T.] Univ Hosp Leuven, Dermatol, Leuven, Belgium.
   [Nikkels, A.] Centre Hospitalier Univ Liege, Dermatol, Liege, Belgium.
   [Willaert, F.] Univ Libre Bruxelles, Erasme Hosp, Dermatol, Brussels, Belgium.
   [Lambert, J.] Univ Hosp Antwerp, Dermatol, Antwerp, Belgium.
C3 Ghent University; Ghent University Hospital; Hasselt University;
   Universite Catholique Louvain; KU Leuven; University Hospital Leuven;
   Universite Libre de Bruxelles; University of Antwerp
RP Lambert, JLW (corresponding author), Ghent Univ Hosp, Dept Dermatol, Ghent, Belgium.
EM jo.lambert@uzgent.be
RI Lambert, Jo/AAG-4880-2021
OI Hillary, Tom/0000-0002-4497-8487; Lambert, Jo/0000-0001-5303-9310
FU Celgene Funding Source: Medline; Eli Lilly Funding Source: Medline;
   Janssen Funding Source: Medline; LEO Pharma Funding Source: Medline;
   Novartis Funding Source: Medline; UCB Funding Source: Medline
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NR 82
TC 31
Z9 34
U1 1
U2 15
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0926-9959
EI 1468-3083
J9 J EUR ACAD DERMATOL
JI J. Eur. Acad. Dermatol. Venereol.
PD AUG
PY 2020
VL 34
IS 8
BP 1654
EP 1665
DI 10.1111/jdv.16684
PG 12
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology
GA MZ2BW
UT WOS:000558926500059
PM 32735076
OA Green Published
DA 2025-06-11
ER

PT J
AU Kim, K
   Jung, SJ
   Baek, JM
   Yim, HW
   Jeong, H
   Kim, DJ
   Park, S
   Youm, Y
   Kim, HC
AF Kim, Kwanghyun
   Jung, Sun Jae
   Baek, Jong Min
   Yim, Hyeon Woo
   Jeong, Hyunsuk
   Kim, Dae Jung
   Park, Sungha
   Youm, Yoosik
   Kim, Hyeon Chang
TI Associations between social network properties and metabolic syndrome
   and the mediating effect of physical activity: findings from the
   Cardiovascular and Metabolic Diseases Etiology Research Center (CMERC)
   Cohort
SO BMJ OPEN DIABETES RESEARCH & CARE
LA English
DT Article
DE metabolic syndrome; physical activity and health; social determinants;
   public health
ID PSYCHOSOCIAL RISK-FACTORS; HEALTH BEHAVIORS; HEART-DISEASE; FOLLOW-UP;
   SUPPORT; OBESITY; EPIDEMIOLOGY; HYPERTENSION; DEPRESSION; MANAGEMENT
AB Introduction Social isolation and loneliness are positively associated with metabolic syndrome. However, the mechanisms by which social isolation affects metabolic syndrome are not well understood.
   Research design and methods This study was designed as a cross-sectional study of baseline results from the Cardiovascular and Metabolic Diseases Etiology Research Center (CMERC) Cohort. We included 10 103 participants (8097 community-based low-risk participants, 2006 hospital-based high-risk participants) from the CMERC Cohort. Participants aged 65 years or older were excluded. Multiple imputation by chained equations was applied to impute missing variables. The quantitative properties of social networks were assessed by measuring the 'size of social networks'; qualitative properties were assessed by measuring the 'social network closeness'. Metabolic syndrome was defined based on the National Cholesterol Education Program Adult Treatment Panel III criteria. Multivariate logistic regression analyses were conducted to assess association between social network properties and metabolic syndrome. The mediating effects of physical inactiveness, alcohol consumption, cigarette smoking and depressive symptoms were estimated. Age-specific effect sizes were estimated for each subgroup.
   Results A smaller social network was positively associated with higher prevalences of metabolic syndrome in all subgroups, except the high-risk male subgroup. There was no clear association between social network closeness and metabolic syndrome. In community-based participants, an indirect effect through physical activity was detected in both sexes; however, in hospital-based participants, no indirect effects were detected. Cigarette smoking, alcohol consumption and depression did not mediate the association. Age-specific estimates showed that the indirect effect through physical activity had a greater impact in older participants.
   Conclusions A smaller social network is positively associated with metabolic syndrome. This trend could be partially explained by physical inactivity, especially in older individuals.
C1 [Kim, Kwanghyun; Jung, Sun Jae; Baek, Jong Min; Kim, Hyeon Chang] Yonsei Univ, Coll Med, Dept Prevent Med, Seodaemun Gu, South Korea.
   [Jung, Sun Jae] Harvard Univ, TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.
   [Yim, Hyeon Woo; Jeong, Hyunsuk] Catholic Univ Korea, Dept Prevent Med, Seoul, South Korea.
   [Kim, Dae Jung] Ajou Univ, Sch Med, Dept Endocrinol & Metab, Suwon, South Korea.
   [Park, Sungha] Yonsei Univ, Coll Med, Div Cardiol, Yonsei Hlth Syst Cardiol Hosp, Seodaemun Gu, South Korea.
   [Youm, Yoosik] Yonsei Univ, Dept Sociol, Seodaemun Gu, South Korea.
C3 Yonsei University; Yonsei University Health System; Harvard University;
   Harvard T.H. Chan School of Public Health; Catholic University of Korea;
   Ajou University; Yonsei University; Yonsei University Health System;
   Yonsei University
RP Jung, SJ (corresponding author), Yonsei Univ, Coll Med, Dept Prevent Med, Seodaemun Gu, South Korea.; Jung, SJ (corresponding author), Harvard Univ, TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.
EM sunjaejung@yuhs.ac
RI Kim, Kwanghyun/JLL-6263-2023; Jung, Sun/ABC-7826-2020; CHIA, YOOK
   CHIN/B-8379-2010; Kim, Dae/AAJ-7518-2021; YOUM, YOOSIK/KBD-0367-2024;
   Jung, Sun Jae/D-5620-2011; Kim, Hyeon Chang/F-8796-2019
OI Park, Sungha/0000-0001-5362-478X; Jung, Sun Jae/0000-0002-5194-7339;
   Kim, Kwanghyun/0000-0001-9552-5085; Baek, Jongmin/0000-0002-1139-9892;
   Youm, Yoosik/0000-0003-3822-5777; Kim, Hyeon Chang/0000-0001-7867-1240
FU Basic Science Research Program through the National Research Foundation
   of Korea (NRF) - Ministry of Science and ICT [2018R1C1B5083722,
   2020R1C1C1003502]
FX This research was supported by Basic Science Research Program through
   the National Research Foundation of Korea (NRF) funded by the Ministry
   of Science and ICT (Grant number 2018R1C1B5083722 and grant number
   2020R1C1C1003502).
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NR 50
TC 12
Z9 13
U1 1
U2 11
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
EI 2052-4897
J9 BMJ OPEN DIAB RES CA
JI BMJ Open Diab. Res. Care
PD JAN
PY 2020
VL 8
IS 1
AR e001272
DI 10.1136/bmjdrc-2020-001272
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism
GA NU7RQ
UT WOS:000573837600024
PM 32675290
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Barry, D
   Pietrzak, RH
   Petry, NM
AF Barry, Danielle
   Pietrzak, Robert H.
   Petry, Nancy M.
TI Gender differences in associations between body mass index and DSM-IV
   mood and anxiety disorders: Results from the National Epidemiologic
   Survey on Alcohol and Related Conditions
SO ANNALS OF EPIDEMIOLOGY
LA English
DT Article
DE overweight; obesity; mood disorders anxiety disorders; sex/hender; risk
ID MAJOR DEPRESSIVE DISORDER; BINGE-EATING DISORDER; BIPOLAR-DISORDER;
   METABOLIC SYNDROME; MENTAL-HEALTH; OBESITY; OVERWEIGHT; PREVALENCE;
   WEIGHT; RISK
AB PURPOSE: The purpose of this study is to examine gender differences in associations between body mass index (BMI) and affective disorders.
   METHODS: We used logistic regression to examine the effects of BMI and gender on Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) mood and anxiety disorders in a sample of 40,790 adults.
   RESULTS: Obesity (BMI > 30.0) was associated with increased risk for any mood disorder, major depressive disorder, and dysthymic disorder, in both men and women (odds ratios [ORs], 1.35-1.88). Risk of bipolar I and II disorders was elevated in obese women (ORs, 1.70-2.41) but not men. Overweight (BMI = 25.0-29.9) predicted increased risk for any mood disorder and bipolar I disorder in women but not in men (ORs, 1.16-1.44). Obesity was associated with increased odds of any anxiety disorder and specific phobia in men and women (ORs, 1.35-1.79). Obese women were additionally at increased risk for social phobia. Overweight predicted increased risk of social phobia and specific phobia for women but not for men (ORs, 1.27-1.37).
   CONCLUSIONS: Obese individuals of both genders are at increased risk for a range of mood and anxiety disorders, but women who are even moderately overweight experience increased risks for some disorders as well.
C1 [Barry, Danielle; Petry, Nancy M.] Univ Connecticut, Ctr Hlth, Dept Psychiat, Farmington, CT 06030 USA.
   [Pietrzak, Robert H.] Univ Connecticut, Dept Psychol, Storrs, CT USA.
C3 University of Connecticut; University of Connecticut
RP Barry, D (corresponding author), Univ Connecticut, Ctr Hlth, Dept Psychiat, 263 Farmington Ave MC 3944, Farmington, CT 06030 USA.
EM barry@psychiatry.uchc.edu
FU NIAAA NIH HHS [P60 AA003510, P50 AA003510] Funding Source: Medline; NIDA
   NIH HHS [R01 DA021567, R01 DA022739, R01 DA018883, P50 DA009241, R01
   DA014618, R01 DA013444, R01 DA016855] Funding Source: Medline; NIMH NIH
   HHS [R01 MH060417] Funding Source: Medline
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NR 49
TC 136
Z9 152
U1 0
U2 17
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1047-2797
EI 1873-2585
J9 ANN EPIDEMIOL
JI Ann. Epidemiol.
PD JUN
PY 2008
VL 18
IS 6
BP 458
EP 466
DI 10.1016/j.annepidem.2007.12.009
PG 9
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA 315IZ
UT WOS:000256873400004
PM 18329894
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Gaughran, F
   Stringer, D
   Berk, M
   Smith, S
   Taylor, D
   Whiskey, E
   Landau, S
   Murray, R
   McGuire, P
   Gardner-Sood, P
   Wojewodka, G
   Ciufolini, S
   Jordan, H
   Clarke, J
   Allen, L
   Krivoy, A
   Stubbs, B
   Lowe, P
   Arbuthnott, M
   Rathod, S
   Boardman, A
   Firdosi, M
   McGrath, JJ
AF Gaughran, Fiona
   Stringer, Dominic
   Berk, Michael
   Smith, Shubulade
   Taylor, David
   Whiskey, Eromona
   Landau, Sabine
   Murray, Robin
   McGuire, Philip
   Gardner-Sood, Poonam
   Wojewodka, Gabriella
   Ciufolini, Simone
   Jordan, Harriet
   Clarke, Jessie
   Allen, Lauren
   Krivoy, Amir
   Stubbs, Brendon
   Lowe, Philippa
   Arbuthnott, Maurice
   Rathod, Shanaya
   Boardman, Andrew
   Firdosi, Mudasir
   McGrath, John J.
TI Vitamin D supplementation compared to placebo in people with First
   Episode psychosis-Neuroprotection Design (DFEND): a protocol for a
   randomised, double-blind, placebo-controlled, parallel-group trial
SO TRIALS
LA English
DT Article
DE Psychosis; First episode; Vitamin D; 25OHD; Randomised controlled trial;
   Positive and Negative Syndrome Scale; Mental health
ID DEPRESSION RATING-SCALE; D DEFICIENCY; GLOBAL ASSESSMENT; METABOLIC
   SYNDROME; MENTAL-ILLNESS; SCHIZOPHRENIA; METAANALYSIS; VALIDITY; RISK;
   RELIABILITY
AB Background People experiencing their first episode of psychosis are often deficient in vitamin D. Observational studies have reported an association between low vitamin D concentrations and poorer subsequent health outcomes in psychosis. A vitamin D deficiency in neonates and children has been linked to a later increased risk of schizophrenia and psychotic-like experiences. This trial aims to examine the effect of high-dose vitamin D supplementation on outcomes in early psychosis. We hypothesise that vitamin D supplementation will be associated with better mental health outcomes. Methods/design The DFEND study is a multicentre double-blind placebo-controlled parallel-group trial of vitamin D supplementation in people with early psychosis. Patients with an ICD-10 diagnosis of functional psychosis will be randomised in a 1:1 ratio to receive either 120,000 IU/month of vitamin D (cholecalciferol) or a matched placebo for 6 months. The primary outcome is the total Positive and Negative Syndrome Scale (PANSS) score at the 6-month follow-up for all patients. Secondary outcomes include assessment of mood (Calgary Depression Scale), general function (Global Assessment of Functioning), cardiovascular risk (body mass index, waist circumference, C-reactive protein, cholesterol and HbA1c) and vitamin D levels at the 6-month follow-up. Additionally, 3- and 6-month total PANSS scores will be analysed for those with inadequate vitamin D levels at the baseline. Discussion The DFEND study is the first trial to examine whether vitamin D supplementation in early psychosis is associated with better mental health outcomes. The findings of this study may help to resolve the clinical equipoise regarding the benefits and cost-effectiveness of routine vitamin D supplementation in people with psychosis.
C1 [Gaughran, Fiona; Smith, Shubulade; Whiskey, Eromona; Murray, Robin; McGuire, Philip; Gardner-Sood, Poonam; Wojewodka, Gabriella; Ciufolini, Simone; Jordan, Harriet; Clarke, Jessie; Allen, Lauren; Krivoy, Amir; Stubbs, Brendon] Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Psychosis Studies, 16 De Crespigny Pk, London SE5 8AF, England.
   [Gaughran, Fiona; Smith, Shubulade; Taylor, David; Whiskey, Eromona; Murray, Robin; McGuire, Philip; Gardner-Sood, Poonam; Ciufolini, Simone; Krivoy, Amir; Stubbs, Brendon] South London & Maudsley NHS Fdn Trust, Denmark Hill, London SE5 8AZ, England.
   [Stringer, Dominic; Landau, Sabine] Kings Coll London, Inst Psychiat, Dept Biostat & Hlth Informat, 16 De Crespigny Pk, London SE5 8AF, England.
   [Berk, Michael] Deakin Univ, Ryrie St, Geelong, Vic 3220, Australia.
   [Berk, Michael] Barwon Hlth, Ryrie St, Geelong, Vic 3220, Australia.
   [Lowe, Philippa] Rethink Mental Illness, Carer Expert & Chair Trustees, 89 Albert Embankment, London SE1 7TP, England.
   [Rathod, Shanaya] Moorgreen Hosp, Res Dept, Tom Rudd Unit, Clin Trials Facil, Southampton SO3 03J, Hants, England.
   [Boardman, Andrew] Cheshire & Wirral Partnership NHS Trust, Churton House,Countess Chester Hlth Pk, Chester CH2 1BQ, Cheshire, England.
   [Firdosi, Mudasir] Queen Marys Hosp, South West London & St Georges Mental Hlth NHS Tr, Roehampton Lane, London SW15 5PN, England.
   [McGrath, John J.] Queensland Ctr Mental Hlth Res, Pk Ctr Mental Hlth, Wacol, Qld 4076, Australia.
   [McGrath, John J.] Univ Queensland, Queensland Brain Inst, Brisbane, Qld 4072, Australia.
   [McGrath, John J.] Aarhus Univ, Natl Ctr Register Based Res, DK-8000 Aarhus C, Denmark.
C3 University of London; King's College London; University of London;
   King's College London; Deakin University; Barwon Health; University of
   London; Queen Mary University London; Queensland Centre for Mental
   Health Research; University of Queensland; Aarhus University
RP Gaughran, F (corresponding author), Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Psychosis Studies, 16 De Crespigny Pk, London SE5 8AF, England.; Gaughran, F (corresponding author), South London & Maudsley NHS Fdn Trust, Denmark Hill, London SE5 8AZ, England.
EM fiona.p.gaughran@kcl.ac.uk
RI Gaughran, Fiona/AAC-7160-2019; Stringer, Dominic/L-5066-2016; McKibben,
   Lauren/MBG-9977-2025; Berk, Michael/AGH-9427-2022; McGuire,
   Philip/AFJ-9527-2022; Stubbs, Brendon/X-1904-2018; Rathod,
   Shanaya/W-2093-2019; Landau, Sabine/B-9354-2011; Whiskey,
   Eromona/KVB-2033-2024; murray, robin/F-8658-2012; Berk,
   Michael/M-7891-2013; Stubbs, Brendon/C-5696-2015; Firdosi,
   Muhammad/P-7974-2019; McGrath, John/G-5493-2010; Gaughran,
   Fiona/H-5495-2011
OI Taylor, David/0000-0002-2557-1710; murray, robin/0000-0003-0829-0519;
   Jordan, Harriet/0000-0002-7268-7310; Ciufolini,
   Simone/0000-0002-1968-5041; Berk, Michael/0000-0002-5554-6946; Landau,
   Sabine/0000-0002-3615-8075; McGuire, Philip/0000-0003-4381-0532;
   Stringer, Dominic/0000-0001-5624-1733; Stubbs,
   Brendon/0000-0001-7387-3791; Wojewodka, Gabriella/0000-0003-4635-4800;
   Firdosi, Muhammad/0000-0002-8450-6484; McGrath,
   John/0000-0002-4792-6068; Gaughran, Fiona/0000-0001-7414-5569
FU Stanley Medical Research Institute; NIHR Collaboration for Leadership in
   Applied Health Research & Care Funding scheme; Maudsley Charity; NIHR
   Maudsley Biomedical Research Centre in South London and Maudsley NHS
   Foundation Trust and King's College London; clinical lectureship within
   the Integrated Clinical Academic Programme - Health Education England;
   NIHR [ICA-CL-2017-03-001]; John Cade Fellowship from the National Health
   and Medical Research Council (Australia) [APP1056929]; National
   Institutes of Health Research (NIHR) [ICA-CL-2017-03-001] Funding
   Source: National Institutes of Health Research (NIHR)
FX Trial funding is provided by the Stanley Medical Research Institute
   (noncommercial). FG and BS are in part supported by the NIHR
   Collaboration for Leadership in Applied Health Research & Care Funding
   scheme and by the Maudsley Charity. FG, SL and BS are funded in part by
   the NIHR Maudsley Biomedical Research Centre in South London and
   Maudsley NHS Foundation Trust and King's College London. BS is supported
   by a clinical lectureship within the Integrated Clinical Academic
   Programme funded by Health Education England and NIHR
   (ICA-CL-2017-03-001). JJMcG is the recipient of a John Cade Fellowship
   (APP1056929) from the National Health and Medical Research Council
   (Australia) and is a Niels Bohr Professor with the Danish National
   Research Foundation. This paper represents independent research and its
   funders have no role in data collection, analysis, interpretation of
   results, writing of the report or the decision to submit for
   publication. The views expressed are those of the authors and not
   necessarily those of the funders, the NHS, the NIHR or the UK Department
   of Health.
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NR 54
TC 7
Z9 7
U1 1
U2 9
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1745-6215
J9 TRIALS
JI Trials
PD JAN 6
PY 2020
VL 21
IS 1
AR 14
DI 10.1186/s13063-019-3758-9
PG 12
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Research & Experimental Medicine
GA KN2BY
UT WOS:000514647500013
PM 31907006
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Bulusu, S
   Sharma, M
AF Bulusu, Sudha
   Sharma, Manisha
TI What does serum -glutamyltransferase tell us as a cardiometabolic risk
   marker?
SO ANNALS OF CLINICAL BIOCHEMISTRY
LA English
DT Review
DE gamma-glutamyltransferase; GGT; cardiovascular risk; cardiovascular
   mortality; diabetes risk; metabolic syndrome risk
ID GAMMA-GLUTAMYL-TRANSFERASE; MIDDLE-AGED MEN; CARDIOVASCULAR-DISEASE
   MORTALITY; FATTY LIVER-DISEASE; TYPE-2 DIABETES-MELLITUS; ALL-CAUSE
   MORTALITY; METABOLIC SYNDROME; ALANINE AMINOTRANSFERASE;
   MYOCARDIAL-INFARCTION; ALCOHOL-CONSUMPTION
AB gamma-glutamyltransferase plays a key role in the synthesis and metabolism of extracellular glutathione, a major antioxidant in several defence mechanisms in the body. -glutamyltransferase is affected by environmental and genetic factors, and is raised when there is depletion of glutathione. Hence, it is a marker of oxidative stress. There is robust evidence that -glutamyltransferase even when values are within the reference interval is associated with increased cardiovascular and all-cause mortality in both sexes, in normal subjects and subjects with coronary artery disease, in the middle-aged and the elderly after adjusting for confounding factors. -glutamyltransferase even within the reference interval is associated with future presentation of type 2 diabetes, and the longitudinal increase in -glutamyltransferase activity is associated with increased risk of type 2 diabetes and cardiovascular mortality. -glutamyltransferase is associated with cardiovascular risk factors and metabolic syndrome. It has a prognostic value after a previous acute myocardial infarction and may be an indicator of adverse outcome in acute coronary syndromes and other chronic cardiac disorders. There is limited data about -glutamyltransferase and any association with peripheral arterial disease and also whether knowing -glutamyltransferase activity improves cardiovascular risk prediction beyond conventional risk factors. -glutamyltransferase is present in atherosclerotic lesions in the coronary and carotid arteries, and has a prooxidant role leading to the production of reactive oxygen species and atherosclerosis. Current reference intervals for -glutamyltransferase are inappropriate and need to be addressed. Some laboratories still use non- International Federation of Clinical Chemistry methods for estimation of -glutamyltransferase which are associated with lower results. Such laboratories should review their method and consider changing to the International Federation of Clinical Chemistry method.
C1 [Bulusu, Sudha; Sharma, Manisha] Homerton Hosp, Dept Clin Biochem, London E9 6SR, England.
RP Bulusu, S (corresponding author), Homerton Hosp, Dept Clin Biochem, London E9 6SR, England.
EM sudhabulusu5@gmail.com
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NR 127
TC 38
Z9 42
U1 1
U2 29
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0004-5632
EI 1758-1001
J9 ANN CLIN BIOCHEM
JI Ann. Clin. Biochem.
PD MAY
PY 2016
VL 53
IS 3
BP 312
EP 332
DI 10.1177/0004563215597010
PG 21
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA DI9UY
UT WOS:000373849400002
PM 26139450
DA 2025-06-11
ER

PT J
AU Alsufyani, MA
   Golant, AK
   Lebwohl, M
AF Alsufyani, Mohammed Ahmed
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   Lebwohl, Mark
TI Psoriasis and the metabolic syndrome
SO DERMATOLOGIC THERAPY
LA English
DT Article
DE comorbidities; metabolic syndrome; psoriasis
ID C-REACTIVE PROTEIN; MYOCARDIAL-INFARCTION; CARDIOVASCULAR-DISEASE;
   VASCULAR-DISEASES; DIABETES-MELLITUS; LEPTIN LEVELS; RISK-FACTORS;
   ADIPONECTIN; OBESITY; PREVALENCE
AB Psoriasis is an inflammatory, immune-mediated cutaneous disorder that has recently been recognized as systemic disease that is associated with multiple comorbidities such as depression, obesity, and the metabolic syndrome. The metabolic syndrome is the constellation of abdominal obesity, dyslipidemia, hypertension and insulin resistance, and presence of the metabolic syndrome significantly increases a patient's risk for cardiovascular disease, stroke and type 2 diabetes. Recent studies have found that psoriasis patients are at increased risk for metabolic syndrome as well as the individual components of metabolic syndrome, and the two diseases appear linked through a common mechanism of inflammation. Speculation exists as to whether this association is causative or whether it is the result of other habits seen in psoriasis patients, such as increased rates of smoking, alcohol consumption, and sedentary lifestyle, which add to the complexity of the association between psoriasis and the metabolic syndrome. However, psoriasis treatments have been shown to reduce the risk of developing metabolic syndrome components and comorbidities. Future studies are needed to better understand the nature of this relationship and the implications this could have for management and treatment of patients with psoriasis.
C1 [Golant, Alexandra K.; Lebwohl, Mark] Mt Sinai Sch Med, Dept Dermatol, New York, NY 10029 USA.
   [Alsufyani, Mohammed Ahmed] Riyadh Mil Hosp, Dept Dermatol, Riyadh, Saudi Arabia.
C3 Icahn School of Medicine at Mount Sinai; Prince Sultan Military Medical
   City
RP Lebwohl, M (corresponding author), Mt Sinai Sch Med, Dept Dermatol, Box 1048,5 E 98th St, New York, NY 10029 USA.
EM lebwohl@aol.com
RI Alsufyani, Mohammed/HHN-4067-2022
OI Alsufyani, Mohammed/0000-0002-2668-9331
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NR 62
TC 50
Z9 56
U1 0
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1396-0296
EI 1529-8019
J9 DERMATOL THER
JI Dermatol. Ther.
PD MAR-APR
PY 2010
VL 23
IS 2
BP 137
EP 143
DI 10.1111/j.1529-8019.2010.01307.x
PG 7
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 574RT
UT WOS:000276011200006
PM 20415820
DA 2025-06-11
ER

PT J
AU Valeanu, A
   Margina, D
   Weber, D
   Stuetz, W
   Moreno-Villanueva, M
   Dollé, MET
   Jansen, EHJM
   Gonos, ES
   Bernhardt, J
   Grubeck-Loebenstein, B
   Weinberger, B
   Fiegl, S
   Sikora, E
   Mosieniak, G
   Toussaint, O
   Debacq-Chainiaux, F
   Capri, M
   Garagnani, P
   Pirazzini, C
   Bacalini, MG
   Hervonen, A
   Slagboom, PE
   Talbot, D
   Breusing, N
   Frank, J
   Bürkle, A
   Franceschi, C
   Grune, T
   Gradinaru, D
AF Valeanu, Andrei
   Margina, Denisa
   Weber, Daniela
   Stuetz, Wolfgang
   Moreno-Villanueva, Maria
   Dolle, Martijn E. T.
   Jansen, Eugene H. J. M.
   Gonos, Efstathios S.
   Bernhardt, Juergen
   Grubeck-Loebenstein, Beatrix
   Weinberger, Birgit
   Fiegl, Simone
   Sikora, Ewa
   Mosieniak, Grazyna
   Toussaint, Olivier
   Debacq-Chainiaux, Florence
   Capri, Miriam
   Garagnani, Paolo
   Pirazzini, Chiara
   Bacalini, Maria Giulia
   Hervonen, Antti
   Slagboom, P. Eline
   Talbot, Duncan
   Breusing, Nicolle
   Frank, Jan
   Buerkle, Alexander
   Franceschi, Claudio
   Grune, Tilman
   Gradinaru, Daniela
TI Development and validation of cardiometabolic risk predictive models
   based on LDL oxidation and candidate geromarkers from the MARK-AGE data
SO MECHANISMS OF AGEING AND DEVELOPMENT
LA English
DT Article
DE LDL oxidation; MARK-AGE; Vascular ageing; Cardiometabolic risk; Machine
   learning
ID LIPID-PEROXIDATION; INSULIN-RESISTANCE; IN-VITRO; BIOMARKERS; STRESS;
   HYPERTENSION; ASSOCIATION; GENDER; TIME
AB The predictive value of the susceptibility to oxidation of LDL particles (LDLox) in cardiometabolic risk assessment is incompletely understood. The main objective of the current study was to assess its relationship with other relevant biomarkers and cardiometabolic risk factors from MARK-AGE data. A cross-sectional observational study was carried out on 1089 subjects (528 men and 561 women), aged 40-75 years old, randomly recruited age- and sex-stratified individuals from the general population. A correlation analysis exploring the relationships between LDLox and relevant biomarkers was undertaken, as well as the development and validation of several machine learning algorithms, for estimating the risk of the combined status of high blood pressure and obesity for the MARK-AGE subjects. The machine learning models yielded Area Under the Receiver Operating Characteristic Curve Score ranging 0.783-0.839 for the internal validation, while the external validation resulted in an Under the Receiver Operating Characteristic Curve Score between 0.648 and 0.787, with the variables based on LDLox reaching significant importance within the obtained predictions. The current study offers novel insights regarding the combined effects of LDL oxidation and other ageing markers on cardiometabolic risk. Future studies might be extended on larger patient cohorts, in order to obtain reproducible clinical assessment models.
C1 [Valeanu, Andrei; Margina, Denisa; Gradinaru, Daniela] Carol Davila Univ Med & Pharm, Fac Pharm, 6 Traian Vuia St, Bucharest 020956, Romania.
   [Weber, Daniela; Grune, Tilman] German Inst Human Nutr, Dept Mol Toxicol, Potsdam Rehbrucke, D-14558 Nuthetal, Germany.
   [Weber, Daniela; Grune, Tilman] NutriAct Competence Cluster Nutr Res Berlin Potsda, D-14458 Nuthetal, Germany.
   [Stuetz, Wolfgang; Frank, Jan] Univ Hohenheim, Inst Nutr Sci 140, Dept Food Biofunct, D-70599 Stuttgart, Germany.
   [Moreno-Villanueva, Maria; Buerkle, Alexander] Univ Konstanz, Mol Toxicol Grp, Dept Biol, D-78457 Constance, Germany.
   [Moreno-Villanueva, Maria] Univ Konstanz, Human Performance Res Ctr, Dept Sport Sci, D-78457 Constance, Germany.
   [Dolle, Martijn E. T.; Jansen, Eugene H. J. M.] Natl Inst Publ Hlth & Environm, Ctr Hlth Protect`, POB 1, NL-3720 BA Bilthoven, Netherlands.
   [Gonos, Efstathios S.] Natl Hellen Res Fdn, Inst Biol Med Chem & Biotechnol, Athens, Greece.
   [Bernhardt, Juergen] BioTeSys GmbH, Schelztor Str 54 56, D-73728 Esslingen, Germany.
   [Grubeck-Loebenstein, Beatrix; Weinberger, Birgit] Univ Innsbruck, Res Inst Biomed Aging Res, Rennweg 10, AT-6020 Innsbruck, Austria.
   [Fiegl, Simone] UMIT TIROL Private Univ Hlth Sci Med Informat & Te, A-6060 Hall In Tirol, Austria.
   [Sikora, Ewa; Mosieniak, Grazyna] Polish Acad Sci, Nencki Inst Expt Biol, Lab Mol Bases Ageing, 3 Pasteur St, PL-02093 Warsaw, Poland.
   [Toussaint, Olivier; Debacq-Chainiaux, Florence] Univ Namur, URBC NARILIS, Rue Bruxelles 61, Namur, Belgium.
   [Capri, Miriam; Garagnani, Paolo; Pirazzini, Chiara; Franceschi, Claudio] Univ Bologna, Dept Med & Surg Sci DIMEC, Alma Mater Studiorum, I-40126 Bologna, Italy.
   [Capri, Miriam] Univ Bologna, Alma Mater Res Inst Global Challenges & Climate Ch, I-40126 Bologna, Italy.
   [Garagnani, Paolo] IRCCS Azienda Osped Univ Bologna, Bologna, Italy.
   [Bacalini, Maria Giulia] IRCCS Ist Sci Neurol Bologna, Bologna, Italy.
   [Hervonen, Antti] Univ Tampere, Med Sch, Tampere 33014, Finland.
   [Slagboom, P. Eline] Leiden Univ, Med Ctr, Sect Mol Epidemiol, Leiden, Netherlands.
   [Talbot, Duncan] Beauty & Personal Care, Dept Unilever Sci & Technol, Sharnbrook, England.
   [Breusing, Nicolle] Univ Hohenheim, Inst Nutr Med, Dept Appl Nutr Sci Dietet, D-70599 Stuttgart, Germany.
   [Franceschi, Claudio] NI Lobachevsky State Univ, Inst Biol & Biomed, Lab Syst Med Healthy Aging, Nizhnii Novgorod 603005, Russia.
   [Franceschi, Claudio] NI Lobachevsky State Univ, Inst Informat Technol Math & Mech, Dept Appl Math, Nizhnii Novgorod 603005, Russia.
   [Grune, Tilman] German Ctr Diabet Res DZD, D-85764 Munich, Germany.
   [Grune, Tilman] German Ctr Cardiovasc Res DZHK, Partner Site Berlin, D-13347 Berlin, Germany.
   [Grune, Tilman] Univ Potsdam, Inst Nutr Sci, D-14558 Nuthetal, Germany.
   [Grune, Tilman] Univ Vienna, Fac Chem, Dept Physiol Chem, A-1090 Vienna, Austria.
   [Gradinaru, Daniela] Ana Aslan Natl Inst Gerontol & Geriatr, Bucharest, Romania.
C3 Carol Davila University of Medicine & Pharmacy; Leibniz Association;
   Deutsches Institut fur Ernahrungsforschung Potsdam-Rehbrucke (DIfE);
   University Hohenheim; University of Konstanz; University of Konstanz;
   Netherlands National Institute for Public Health & the Environment;
   National Hellenic Research Foundation; University of Innsbruck; Polish
   Academy of Sciences; Nencki Institute of Experimental Biology of the
   Polish Academy of Sciences; University of Namur; University of Bologna;
   University of Bologna; IRCCS Azienda Ospedaliero-Universitaria di
   Bologna; IRCCS Istituto delle Scienze Neurologiche di Bologna (ISNB);
   Tampere University; Leiden University; Leiden University Medical Center
   (LUMC); Leiden University - Excl LUMC; University Hohenheim; Lobachevsky
   State University of Nizhni Novgorod; Lobachevsky State University of
   Nizhni Novgorod; German Center for Diabetes Research (DZD); German
   Centre for Cardiovascular Research; University of Potsdam; University of
   Vienna; National Institute of Gerontology & Geriatrics "Ana Aslan"
RP Valeanu, A (corresponding author), Carol Davila Univ Med & Pharm, Fac Pharm, 6 Traian Vuia St, Bucharest 020956, Romania.
EM andrei.valeanu@umfcd.ro; denisa.margina@umfcd.ro;
   daniela.gradinaru@umfcd.ro; wolfgang.stuetz@uni-hohenheim.de;
   maria.moreno-villanueva@uni-konstanz.de; Martijn.Dolle@rivm.nl;
   eugenejansen99@gmail.com; sgonos@eie.gr; j.bernhardt@biotesys.de;
   Beatrix.Grubeck-Loebenstein@uibk.ac.at; birgit.weinberger@uibk.ac.at;
   simone.fiegl@umit-tirol.at; e.sikora@nencki.edu.pl;
   g.mosieniak@nencki.edu.pl; florence.chainiaux@unamur.be;
   miriam.capri@unibo.it; paolo.garagnani2@unibo.it; pirazzini5@unibo.it;
   maria.moreno-villanueva@uni-konstanz.de; antti.hervonen@gmail.com;
   p.slagboom@lumc.nl; scoutwell.supplies@btinternet.com;
   nicolle_breusing@yahoo.de; jan.frank@uni-hohenheim.de;
   alexander.buerkle@uni-konstanz.de; claudio.franceschi@unibo.it;
   scientific.director@dife.de; daniela.gradinaru@umfcd.ro
RI Slagboom, P./R-4790-2016; Valeanu, Andrei/P-2950-2016; Weinberger,
   Birgit/ABC-5233-2020; Bacalini, Maria/K-4931-2016; Franceschi,
   Claudio/L-4484-2017; Pirazzini, Chiara/AAD-9318-2021; Margina,
   Denisa/J-7312-2013
OI Pirazzini, Chiara/0000-0001-8248-0295; Margina,
   Denisa/0000-0003-3289-147X
FU European Commission [200880]; The "Carol Davila" University of Medicine
   and Pharmacy, Bucharest
FX This work was supported by the European Commission (Project Full Name:
   European Study to Establish Biomarkers of Human Ageing; Project Acronym:
   MARK-AGE; Project No. 200880) . The current research and publication
   were undertaken with the support of "Carol Davila" University of
   Medicine and Pharmacy, Bucharest.
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NR 84
TC 2
Z9 2
U1 3
U2 4
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0047-6374
EI 1872-6216
J9 MECH AGEING DEV
JI Mech. Ageing Dev.
PD DEC
PY 2024
VL 222
AR 111987
DI 10.1016/j.mad.2024.111987
EA SEP 2024
PG 15
WC Cell Biology; Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Geriatrics & Gerontology
GA G8Z2O
UT WOS:001319448500001
PM 39284459
OA hybrid
DA 2025-06-11
ER

PT J
AU Pan, A
   Keum, N
   Okereke, OI
   Sun, Q
   Kivimaki, M
   Rubin, RR
   Hu, FB
AF Pan, An
   Keum, Nana
   Okereke, Olivia I.
   Sun, Qi
   Kivimaki, Mika
   Rubin, Richard R.
   Hu, Frank B.
TI Bidirectional Association Between Depression and Metabolic Syndrome A
   systematic review and meta-analysis of epidemiological studies
SO DIABETES CARE
LA English
DT Review
ID CARDIOVASCULAR-DISEASE; HEALTH; SYMPTOMS; OBESITY; POPULATION;
   DISORDERS; BIOLOGY; ANXIETY; LEPTIN; WOMEN
AB OBJECTIVE-Epidemiological studies have repeatedly investigated the association between depression and metabolic syndrome (MetS). However, the results have been inconsistent. This meta-analysis aimed to summarize the current evidence from cross-sectional and prospective cohort studies that evaluated this association.
   RESEARCH DESIGN AND METHODS-MEDLINE, EMBASE, and PsycINFO data-bases were searched for articles published up to January 2012. Cross-sectional and cohort studies that reported an association between the two conditions in adults were included. Data on prevalence, incidence, unadjusted or adjusted odds ratio (OR), and 95% Cl were extracted or provided by the authors. The pooled OR was calculated separately for cross-sectional and cohort studies using random-effects models. The 12 statistic was used to assess heterogeneity.
   RESULTS-The search yielded 29 cross-sectional studies (n = 155,333): 27 studies reported unadjusted OR with a pooled estimate of 1.42 (95% CI 1.28-1.57; I-2 = 55.1%); 11 studies reported adjusted OR with depression as the outcome (1.27 [1.07-1.57]; I-2 = 60.9%), and 12 studies reported adjusted OR with MetS as the outcome (1.34 [1.18-1.51]; I-2 = 0%). Eleven cohort studies were found (2 studies reported both directions): 9 studies (n = 26,936 with 2,316 new-onset depression case subjects) reported adjusted OR with depression as the outcome (1.49 [1.19-1.87]; I-2 = 56.8%), 4 studies (n = 3,834 with 350 MetS case subjects) reported adjusted OR with MetS as the outcome (1.52 [1.20-1.91]; I-2 = 0%).
   CONCLUSIONS-Our results indicate a bidirectional association between depression and MetS. These results support early detection and management of depression among patients with MetS and vice versa.
C1 [Pan, An; Keum, Nana; Sun, Qi; Hu, Frank B.] Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA.
   [Okereke, Olivia I.; Hu, Frank B.] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.
   [Okereke, Olivia I.; Sun, Qi; Hu, Frank B.] Brigham & Womens Hosp, Dept Med, Channing Lab, Boston, MA USA.
   [Okereke, Olivia I.] Brigham & Womens Hosp, Dept Psychiat, Boston, MA USA.
   [Okereke, Olivia I.; Sun, Qi; Hu, Frank B.] Harvard Univ, Sch Med, Boston, MA USA.
   [Kivimaki, Mika] UCL, Dept Epidemiol & Publ Hlth, London, England.
   [Rubin, Richard R.] Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21205 USA.
   [Rubin, Richard R.] Johns Hopkins Univ, Sch Med, Dept Pediat, Baltimore, MD 21205 USA.
C3 Harvard University; Harvard T.H. Chan School of Public Health; Harvard
   University; Harvard T.H. Chan School of Public Health; Harvard
   University; Harvard University Medical Affiliates; Brigham & Women's
   Hospital; Harvard University; Harvard University Medical Affiliates;
   Brigham & Women's Hospital; Harvard University; Harvard Medical School;
   University of London; University College London; Johns Hopkins
   University; Johns Hopkins University
RP Hu, FB (corresponding author), Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA.
EM apan@hsph.harvard.edu; frank.hu@channing.harvard.edu
RI Hu, Frank/C-1919-2013; Sun, Qi/KVY-1113-2024; Okereke,
   Olivia/R-9934-2016; Kivimaki, Mika/B-3607-2012; Pan, An/C-5572-2011
OI Pan, An/0000-0002-1089-7945; Kivimaki, Mika/0000-0002-4699-5627; Sun,
   Qi/0000-0002-8480-1563
FU NIH from National Institute on Aging [K08-AG-029813]; National Institute
   of Mental Health [R01-MH-091448]; National Heart, Lung, and Blood
   Institute [K99-HL-098459]; National Institutes of Health (NIH)
   [R01-HL-036310, R01-AG-034454, DK-58845]; Academy of Finland; BUPA
   Foundation, U.K.; MRC [G0902037] Funding Source: UKRI
FX O.I.O. was supported by NIH Career Development Award K08-AG-029813 from
   the National Institute on Aging and R01-MH-091448 from the National
   Institute of Mental Health. Q.S. was supported by Career Development
   Award K99-HL-098459 from the National Heart, Lung, and Blood Institute.
   M.K. was supported by the National Institutes of Health (NIH) Grants
   R01-HL-036310 and R01-AG-034454, the Academy of Finland, and the BUPA
   Foundation, U.K. F.B.H. was supported by NIH Grant DK-58845. The funding
   sources were not involved in data collection and analysis, writing, or
   publication of this article.
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NR 40
TC 564
Z9 598
U1 0
U2 62
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0149-5992
EI 1935-5548
J9 DIABETES CARE
JI Diabetes Care
PD MAY
PY 2012
VL 35
IS 5
BP 1171
EP 1180
DI 10.2337/dc11-2055
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 931KN
UT WOS:000303218900041
PM 22517938
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Lanas, F
   Saavedra, N
   Saavedra, K
   Hevia, M
   Seron, P
   Salazar, LA
AF Lanas, Fernando
   Saavedra, Nicolas
   Saavedra, Kathleen
   Hevia, Montserrat
   Seron, Pamela
   Salazar, Luis A.
TI Effect of intermediate-term firewood smoke air pollution on
   cardiometabolic risk factors and inflammatory markers
SO FRONTIERS IN CARDIOVASCULAR MEDICINE
LA English
DT Article
DE air pollution; cardiometabolic risk factors; inflammatory cytokines;
   cold weather; cardiovascular risk
ID PARTICULATE MATTER; BLOOD-PRESSURE; CARDIOVASCULAR-DISEASE; OXIDATIVE
   STRESS; EXPOSURE; ATHEROSCLEROSIS; ASSOCIATIONS; PM2.5; POLLUTANTS;
   INDOOR
AB Background: Temuco is a city in Southern Chile with elevated levels of air pollution (AP), mainly due to using wood as combustion throughout the cold season. The study aimed to assess the differences in cardiometabolic risk factors, estimated cardiovascular risk, and blood level of inflammatory markers between high AP (HAP) and low AP (LAP) periods.Methods: A prospective panel study was conducted between January to September 2018. Air pollution was assessed by PM2.5 concentration. Ninety individuals from the general population were included in the study. Measurements were performed in the HAP and LAP, including medical history and lifestyle, physical activity assessment, physical exam, and fasting blood samples for glucose, lipids, and circulatory inflammatory mediators.Results: In the high air pollution period, systolic blood pressure was 3 mmHg higher (p = 0.05). HDL-cholesterol was 14.2 mg/dl lower (p < 0.001), Framingham risk score increased from 14.5 to 18.0 (p < 0.001), and highly significant lower levels of interleukins, MCP1, MMP1, MMP2, sICAM, and svCAM were observed.Conclusions: HAP was associated with increased cardiometabolic risk factors and estimated cardiovascular risk. However, a lower level of circulating acute inflammatory molecules was observed. Inflammatory molecules blood levels were not associated with changes in cardiometabolic risk factors.
C1 [Lanas, Fernando; Seron, Pamela] Univ La Frontera, Dept Internal Med, Temuco, Chile.
   [Saavedra, Nicolas; Saavedra, Kathleen; Hevia, Montserrat; Salazar, Luis A.] Univ La Frontera, Dept Basic Sci, Temuco, Chile.
C3 Universidad de La Frontera; Universidad de La Frontera
RP Lanas, F (corresponding author), Univ La Frontera, Dept Internal Med, Temuco, Chile.
EM lanastomas@gmail.com
RI Saavedra, Kathleen/GNH-6255-2022; Saavedra, Nicolás/H-7417-2017; da
   Silva Cruz, Luis/A-9125-2011; Seron, Pamela/AAN-3304-2021; Lanas,
   Fernando/B-4633-2014
OI Seron, Pamela/0000-0003-0190-8988; Saavedra Cuevas, Nicolas
   Rene/0000-0002-3334-5107
FU Fondecyt
FX No Statement Available
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NR 44
TC 2
Z9 2
U1 1
U2 3
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2297-055X
J9 FRONT CARDIOVASC MED
JI Front. Cardiovasc. Med.
PD NOV 21
PY 2023
VL 10
AR 1252542
DI 10.3389/fcvm.2023.1252542
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA AA7C8
UT WOS:001115787200001
PM 38075980
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Cowey, S
   Hardy, RW
AF Cowey, Stephanie
   Hardy, Robert W.
TI The metabolic syndrome - A high-risk state for cancer?
SO AMERICAN JOURNAL OF PATHOLOGY
LA English
DT Review
ID ENDOTHELIAL GROWTH-FACTOR; BODY-MASS INDEX; BREAST-CANCER; ENDOMETRIAL
   CANCER; INSULIN-RESISTANCE; OXIDATIVE STRESS; ADIPOSE-TISSUE;
   LIPID-PEROXIDATION; FAT DISTRIBUTION; BLOOD-GLUCOSE
AB The metabolic syndrome is composed of cardiovascular risk factors including increased body mass index/waist circumference, blood pressure, plasma glucose, and triglycerides, as well as decreased high-density lipoprotein cholesterol. The essence of the metabolic syndrome lies in the clustering of these risk factors, which are associated with cardiovascular disease. interestingly, most of the components of the metabolic syndrome have individually been linked in some way to the development of cancer. However, epidemiological studies linking the metabolic syndrome to cancer are scarce. Nevertheless, two such studies indicate that the clustering of metabolic syndrome components significantly increases the risk of colon cancer mortality compared with the individual components. The purpose of this review is to further explore the potential relationship between the metabolic syndrome and cancer risk. Specifically, we examine the hypothesis that individual components of the metabolic syndrome contribute to the development of several processes, including insulin resistance, aromatase activity, adipokine production, angiogenesis, glucose utilization, and oxidative stress/DNA damage, which can work together to increase cancer risk beyond that of the individual components alone. We propose that the metabolic syndrome be considered as a high-risk state for certain types of cancer and that this relationship should be systematical1y explored across cancer types.
C1 Univ Alabama Birmingham, Dept Pathol, Div Lab Med, Birmingham, AL 35294 USA.
C3 University of Alabama System; University of Alabama Birmingham
RP Hardy, RW (corresponding author), Univ Alabama Birmingham, Dept Pathol, Div Lab Med, 701 S 19th St,LHRB Room 531, Birmingham, AL 35294 USA.
EM hardy@path.uab.edu
FU NCCIH NIH HHS [R21 AT001636, R21AT01636] Funding Source: Medline; NIAMS
   NIH HHS [T32AR047512, T32 AR047512] Funding Source: Medline
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NR 83
TC 346
Z9 381
U1 0
U2 16
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0002-9440
EI 1525-2191
J9 AM J PATHOL
JI Am. J. Pathol.
PD NOV
PY 2006
VL 169
IS 5
BP 1505
EP 1522
DI 10.2353/ajpath.2006.051090
PG 18
WC Pathology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pathology
GA 099OD
UT WOS:000241603700001
PM 17071576
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Chen, MC
   Hsu, BG
   Lee, CJ
   Wang, JH
AF Chen, Ming-Chun
   Hsu, Bang-Gee
   Lee, Chung-Jen
   Wang, Ji-Hung
TI Hyperleptinaemia positively correlates with cardiometabolic syndrome in
   hypertensive patients
SO INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY
LA English
DT Article
DE Leptin; metabolic syndrome; hypertension
ID SERUM LEPTIN LEVELS; ACTING NATRIURETIC PEPTIDE; CENTRAL ARTERIAL
   STIFFNESS; C-REACTIVE PROTEIN; METABOLIC SYNDROME; INSULIN-RESISTANCE;
   PLASMA LEPTIN; BODY-FAT; DIABETES-MELLITUS; OXIDATIVE STRESS
AB Leptin is involved in several homeostatic functions beyond fat storage. Hyperleptinaemia has been implicated in metabolic syndrome (MetS) and cardiovascular disease (CVD). The aim of this study was to determine the relationship between serum leptin concentration and cardiometabolic risk factors in hypertensive patients. Fasting blood samples and baseline characteristics were obtained from 124 hypertensive patients. Serum leptin concentrations were determined using a commercially available enzyme immunoassay (EIA) kit. Seventy patients (56.4%) with cardiometabolic syndrome had higher serum leptin (P < 0.001), C-reactive protein (CRP; P = 0.002), insulin (P < 0.001), body mass index (BMI; P < 0.001) and homeostasis model assessment of insulin resistance (HOMA-IR; P < 0.001) values and higher percentages of type 2 diabetes mellitus (P = 0.039) and coronary artery disease (P = 0.034) than those in the non-cardiometabolic syndrome group. Serum leptin levels positively correlated with body weight (P = 0.006), waist circumference (P < 0.001), BMI (P < 0.001), total cholesterol (P = 0.025), logarithmically transformed triglyceride (log-triglyceride; P = 0.008), log-CRP (P < 0.001), log-insulin (P = 0.001) and log-HOMA-IR (P = 0.009) and negatively correlated with glomerular filtration rate (GFR) (P = 0.016) in hypertensive patients. After adjusting for factors significantly associated with serum leptin level, multivariate stepwise linear regression analysis showed that BMI (P < 0.001), female gender (P < 0.001), log-CRP (P < 0.001), statin use (P = 0.001), log-triglyceride (P = 0.013) and GFR (P = 0.032) were independent predictors of fasting serum log-leptin levels among hypertensive patients. This study showed that serum leptin levels are a strong predictor and might be a useful diagnostic surrogate of cardiometabolic syndrome in hypertensive patients.
C1 [Chen, Ming-Chun] Buddhist Tzu Chi Gen Hosp, Dept Pediat, Hualien, Taiwan.
   [Hsu, Bang-Gee] Buddhist Tzu Chi Gen Hosp, Div Nephrol, Hualien, Taiwan.
   [Wang, Ji-Hung] Buddhist Tzu Chi Gen Hosp, Div Cardiol, 707,Sect 3,Chung Yang Rd, Hualien, Taiwan.
   [Hsu, Bang-Gee; Wang, Ji-Hung] Tzu Chi Univ, Sch Med, Hualien, Taiwan.
   [Lee, Chung-Jen] Tzu Chi Univ Sci & Technol, Dept Nursing, Hualien, Taiwan.
C3 Buddhist Tzu Chi General Hospital; Hualien Tzu Chi Hospital; Buddhist
   Tzu Chi General Hospital; Hualien Tzu Chi Hospital; Buddhist Tzu Chi
   General Hospital; Hualien Tzu Chi Hospital; Tzu Chi University; Tzu Chi
   University of Science & Technology
RP Wang, JH (corresponding author), Buddhist Tzu Chi Gen Hosp, Div Cardiol, 707,Sect 3,Chung Yang Rd, Hualien, Taiwan.
EM abanggeelily@gmail.com
RI Hsu, Bang-Gee/AAV-5287-2020; Chen, Ming-Chun/AAF-9613-2019
OI Chen, Ming-Chun/0000-0003-0910-1185
FU Buddhist Tzu Chi General Hospital, Hualien, Taiwan [TCRD101-03]
FX This study was supported by a grant from the Buddhist Tzu Chi General
   Hospital, Hualien, Taiwan (TCRD101-03).
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NR 50
TC 19
Z9 19
U1 0
U2 3
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 1936-2625
J9 INT J CLIN EXP PATHO
JI Int. J. Clin. Exp. Pathol.
PY 2016
VL 9
IS 12
BP 12959
EP 12967
PG 9
WC Oncology; Pathology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Pathology
GA EF5YP
UT WOS:000390406200087
DA 2025-06-11
ER

PT J
AU Baur, DM
   Christophi, CA
   Kales, SN
AF Baur, Dorothee M.
   Christophi, Costas A.
   Kales, Stefanos N.
TI METABOLIC SYNDROME IS INVERSELY RELATED TO CARDIORESPIRATORY FITNESS IN
   MALE CAREER FIREFIGHTERS
SO JOURNAL OF STRENGTH AND CONDITIONING RESEARCH
LA English
DT Article
DE cardiovascular risk factors; stress testing; fitness; obesity; public
   safety; cardiometabolic risk
ID CORONARY-HEART-DISEASE; BODY-MASS INDEX; CARDIOVASCULAR-DISEASE;
   PHYSICAL-ACTIVITY; POLICE OFFICERS; UNITED-STATES; RISK-FACTORS;
   PREVALENCE; MORTALITY; HEALTH
AB Baur, DM, Christophi, CA, and Kales, SN. Metabolic syndrome is inversely related to cardiorespiratory fitness in male career firefighters. J Strength Cond Res 26(9): 2331-2337, 2012-Cardiovascular disease (CVD) accounts for 45% of on-duty fatalities among firefighters, occurring primarily in firefighters with excess CVD risk factors in patterns resembling the metabolic syndrome (MetSyn). Additionally, firefighters have a high prevalence of obesity and sedentary behavior suggesting that MetSyn is also common. Therefore, we assessed the prevalence of MetSyn in firefighters and its association with cardiorespiratory fitness (CRF) in a cross-sectional study of 957 male career firefighters. The CRF was measured by maximal exercise tolerance testing (standard metabolic equivalent [METS]). The MetSyn was defined according to modified criteria from the Joint Scientific Statement. Group differences were compared using chi(2)-test and logistic regression. The prevalence of MetSyn was 28.3%. Firefighters in the lowest fitness category (METS <= 10) had a nearly 10-fold higher prevalence of MetSyn (51.2%) compared with colleagues in the highest fitness category (METS > 14) (MetSyn prevalence 5.2%) (p value < 0.0001, adjusted for age). In multivariate regression models, every 1-unit increase in METS decreased the odds of having the MetSyn by 31% (odds ratio 0.69 [95% confidence interval 0.63-0.76] [age adjusted]), whereas age had no significant effect after adjusting for CRF. We found a high prevalence of the MetSyn in this group of career emergency responders expected to be more active, fit, and relatively younger than the general population. Moreover, there is a highly significant inverse, dose-response association with CRF. Firefighters should be given strong incentives to improve their fitness, which would decrease prevalent MetSyn, a likely precursor of on-duty CVD events and contributor to CVD burden in this population.
C1 [Baur, Dorothee M.; Christophi, Costas A.; Kales, Stefanos N.] Harvard Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA 02115 USA.
   [Baur, Dorothee M.; Kales, Stefanos N.] Harvard Univ, Sch Med, Cambridge Hlth Alliance, Cambridge, MA 02138 USA.
   [Christophi, Costas A.] Cyprus Univ Technol, Cyprus Int Inst Environm & Publ Hlth, Harvard Sch Publ Hlth, Limassol, Cyprus.
C3 Harvard University; Harvard T.H. Chan School of Public Health; Harvard
   University; Harvard University Medical Affiliates; Cambridge Health
   Alliance; Cyprus University of Technology; Cyprus International
   Institute for Environmental & Public Health
RP Kales, SN (corresponding author), Harvard Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA 02115 USA.
EM skales@challiance.org
OI Christophi, Costas/0000-0003-0503-1538
FU Federal Emergency Management Agency (FEMA) Assistance to Fire-fighters
   Grant (AFG) program's awards [EMW-2006-FP-01493, EMW-2009-FP-00835,
   EMW-2007-FP-02197]
FX The authors would like to thank all of the participating firefighters
   and Fire Departments; the staff and clinical leadership of the clinics
   who examined the firefighters; Dr. Sara Jahnke, Ms. Brianne Tuley, Dr.
   Antonios Tsismenakis, Dr. Lilly Ramphal, and the late Dr. William
   Patterson for their contributions to the underlying longitudinal study.
   The authors also thank Dr. Charles A. Czeisler, Dr. Steven W. Lockley,
   Mr. Jason Sullivan, and 'the Harvard Work Hours Health and Safety Group'
   for providing data on one of the fire departments. This investigation
   was supported by the Federal Emergency Management Agency (FEMA)
   Assistance to Fire-fighters Grant (AFG) program's awards
   EMW-2006-FP-01493 (PI: Dr. S.N. Kales), EMW-2009-FP-00835 (PI: Dr. S.N.
   Kales), and EMW-2007-FP-02197 (PI: Dr. C.A. Czeisler). S.N. Kales has
   served as expert witness in medicolegal cases involving firefighters.
   The other authors report no conflict of interest.
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NR 33
TC 56
Z9 62
U1 0
U2 17
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1064-8011
J9 J STRENGTH COND RES
JI J. Strength Cond. Res.
PD SEP
PY 2012
VL 26
IS 9
BP 2331
EP 2337
DI 10.1519/JSC.0b013e31823e9b19
PG 7
WC Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Sport Sciences
GA 001FI
UT WOS:000308445500004
PM 22067249
OA Bronze
DA 2025-06-11
ER

PT J
AU Chou, CL
   Lin, H
   Chen, JS
   Fang, TC
AF Chou, Chu-Lin
   Lin, Heng
   Chen, Jin-Shuen
   Fang, Te-Chao
TI Renin inhibition improves metabolic syndrome, and reduces angiotensin II
   levels and oxidative stress in visceral fat tissues in fructose-fed rats
SO PLOS ONE
LA English
DT Article
ID SPONTANEOUSLY HYPERTENSIVE-RATS; HYPERINSULINEMIA-INDUCED HYPERTENSION;
   INSULIN-RESISTANCE; ADIPOSE-TISSUE; TYPE-1 RECEPTOR; BLOOD-PRESSURE;
   CARDIOVASCULAR CHANGES; VASCULAR DYSFUNCTION; ALISKIREN; EXPRESSION
AB Renin-angiotensin system in visceral fat plays a crucial role in the pathogenesis of metabolic syndrome in fructose-fed rats. However, the effects of renin inhibition on visceral adiposity in metabolic syndrome are not fully investigated. We investigated the effects of renin inhibition on visceral adiposity in fructose-fed rats. Male Wistar-Kyoto rats were divided into 4 groups for 8-week experiments: Group Con (standard chow diet), Group Fru (high-fructose diet; 60% fructose), Group FruA (high-fructose diet and concurrent aliskiren treatment; 100 mg/kg body weight [BW] per day), and Group FruB (high-fructose diet and subsequent, i.e. 4 weeks after initiating high-fructose feeding, aliskiren treatment; 100 mg/kg BW per day). The high-fructose diet induced metabolic syndrome, increased visceral fat weights and adipocyte sizes, and augmented angiotensin II (Ang II), NADPH oxidase (NOX) isoforms expressions, oxidative stress, and dysregulated production of adipocytokines from visceral adipose tissues. Concurrent and subsequent aliskiren administration ameliorated metabolic syndrome, dysregulated adipocytokines, and visceral adiposity in high fructose-fed hypertensive rats, and was associated with reducing Ang II levels, NOX isoforms expressions and oxidative stress in visceral fat tissues. Therefore, this study demonstrates renin inhibition could improve metabolic syndrome, and reduce Ang II levels and oxidative stress in visceral fat tissue in fructose-fed rats, and suggests that visceral adipose Ang II plays a crucial role in the pathogenesis of metabolic syndrome in fructose-fed rats.
C1 [Chou, Chu-Lin; Chen, Jin-Shuen] Natl Def Med Ctr, Div Nephrol, Dept Internal Med, Triserv Gen Hosp, Taipei, Taiwan.
   [Chou, Chu-Lin; Fang, Te-Chao] Taipei Med Univ, Taipei Med Univ Hosp, Div Nephrol, Dept Internal Med, Taipei, Taiwan.
   [Chou, Chu-Lin; Fang, Te-Chao] Taipei Med Univ, Sch Med, Div Nephrol, Dept Internal Med, Taipei, Taiwan.
   [Lin, Heng] Taipei Med Univ, Sch Med, Dept Physiol, Coll Med, Taipei, Taiwan.
   [Fang, Te-Chao] Taipei Med Univ, Wan Fang Hosp, Div Nephrol, Dept Internal Med, Taipei, Taiwan.
C3 Tri-Service General Hospital; National Defense Medical Center; Taipei
   Medical University; Taipei Medical University Hospital; Taipei Medical
   University; Taipei Medical University; Taipei Medical University; Taipei
   Municipal WanFang Hospital
RP Fang, TC (corresponding author), Taipei Med Univ, Taipei Med Univ Hosp, Div Nephrol, Dept Internal Med, Taipei, Taiwan.; Fang, TC (corresponding author), Taipei Med Univ, Sch Med, Div Nephrol, Dept Internal Med, Taipei, Taiwan.; Fang, TC (corresponding author), Taipei Med Univ, Wan Fang Hosp, Div Nephrol, Dept Internal Med, Taipei, Taiwan.
EM fangtechao@yahoo.com.tw
RI CHEN, JUI-YI/AAV-8854-2021; Fang, Te-Chao/V-7731-2017
OI Chou, Chu-Lin/0000-0002-9695-1067; Fang, Te-Chao/0000-0002-5577-9280
FU Ministry of Science and Technology, Taiwan [MOST101-2314-B-303-013-MY3];
   Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan [WFH104-11]
FX This study was funded by the Ministry of Science and Technology, Taiwan
   (https://www. most.gov.tw; MOST101-2314-B-303-013-MY3; Funds for Te-Chao
   Fang) and Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan
   (http:// wfh.tmu.edu.tw; WFH104-11; Funds for Te-Chao Fang). The funder
   had no role in study design, data collection and analysis, decision to
   publish, or preparation of the manuscript.
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NR 54
TC 27
Z9 28
U1 2
U2 11
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JUL 10
PY 2017
VL 12
IS 7
AR e0180712
DI 10.1371/journal.pone.0180712
PG 17
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA FA6HV
UT WOS:000405544800068
PM 28700686
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Li, C
   Yang, L
   Zhang, QY
   Zhang, Y
   Li, RL
   Jia, F
   Wang, LA
   Ma, XY
   Yao, KF
   Tian, HJ
   Liu, ZX
   Zhuo, CJ
AF Li, Chao
   Yang, Lei
   Zhang, Qiuyu
   Zhang, Ying
   Li, Ranli
   Jia, Feng
   Wang, Lina
   Ma, Xiaoyan
   Yao, Kaifang
   Tian, Hongjun
   Liu, Zengxun
   Zhuo, Chuanjun
TI Differentiations in Illness Duration, Thyroid-Stimulating Hormone,
   Glucose and P300 Latency Between Drug-Naive Unipolar and Bipolar
   Depression: A Comparative Cross-Sectional Study
SO NEUROPSYCHIATRIC DISEASE AND TREATMENT
LA English
DT Article
DE unipolar depression; bipolar depression; illness duration;
   thyroid-stimulating hormone; fasting plasma glucose; P300
ID METABOLIC SYNDROME; COGNITIVE DYSFUNCTION; DISORDER; PREVALENCE;
   SCHIZOPHRENIA; METAANALYSIS; CREATIVITY; DIAGNOSIS; FAMILY; RATES
AB Background: Distinguishing bipolar depression (BD) from unipolar depression (UD) remains a major clinical challenge, especially in drug-na & iuml;ve patients. The present study aimed to investigate whether demographic, clinical, and biochemical parameters can help differentiate drug-na & iuml;ve BD from UD. Methods: Drug-na & iuml;ve patients with UD and BD were recruited from Shandong Mental Health Center. Ninety-four inpatients (61 UD and 33 BD) were assessed using the 17-item Hamilton Depression Rating Scale (HAMD-17) and P300 latency. Fasting serum levels of free triiodothyronine (FT3), free thyroxine (FT4), thyroid-stimulating hormone (TSH), as well as fasting plasma glucose (FPG), lipid, C-reactive protein (CRP), and uric acid (UA) indicators were measured. Results: Patients with BD had longer illness duration and P300 latency and lower FT3 levels, but higher levels of TSH and FPG than patients with UD (all P<0.05). Binary logistic regression analysis indicated illness duration, TSH, FPG, and P300 latency were significantly associated with BD. Illness duration, TSH, FPG, and P300 latency achieved an area under the ROC curve of 0.777, 0.699, 0.646, and 0.635, respectively, in discriminating unipolar and bipolar depression. Conclusion: Increased illness duration, serum TSH and FPG levels, and P300 latency were independent risk factors for BD. Demographic, clinical, biochemical, and electrophysiological markers identified may have the potential to distinguish BD from UD.
C1 [Li, Chao; Yang, Lei; Zhang, Qiuyu; Zhang, Ying; Li, Ranli; Jia, Feng; Wang, Lina; Ma, Xiaoyan; Yao, Kaifang; Zhuo, Chuanjun] Tianjin Med Univ, Nankai Univ, Tianjin Anding Hosp, Computat Biol Anim Imaging Ctr CBAC,Tianjin Mental, Tianjin 300222, Peoples R China.
   [Li, Chao; Yang, Lei; Zhang, Qiuyu; Zhang, Ying; Li, Ranli; Jia, Feng; Wang, Lina; Ma, Xiaoyan; Yao, Kaifang; Zhuo, Chuanjun] Tianjin Med Univ, Tianjin Anding Hosp, Lab Psychiat Neuroimaging Genet & Comorbid PNGC La, Tianjin Mental Hlth Ctr, Tianjin 300222, Peoples R China.
   [Tian, Hongjun] Nankai Univ, Tianjin Ctr Hosp 4, Dept Psychiat, Tianjin 300140, Peoples R China.
   [Liu, Zengxun] Shandong Mental Hlth Ctr, Dept Psychiat, Jinan 250014, Peoples R China.
C3 Tianjin Medical University; Nankai University; Tianjin Medical
   University; Nankai University
RP Zhuo, CJ (corresponding author), Nankai Univ, Tianjin Med Univ, Tianjin Mental Hlth Ctr, Tianjin Anding Hosp, Tianjin 300222, Peoples R China.
EM chuanjunzhuotjmh@163.com
RI li, Chao/LDG-3210-2024; zhang, qiuyu/JOZ-6737-2023
FU National Natural Science Foundation of China [81871052, 81701326]
FX This work was supported by grants from the National Natural Science
   Foundation of China (Nos. 81871052 and 81701326) to Chuanjun Zhuo.
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NR 56
TC 0
Z9 0
U1 2
U2 2
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
EI 1178-2021
J9 NEUROPSYCH DIS TREAT
JI Neuropsychiatr. Dis. Treat.
PY 2025
VL 21
BP 157
EP 166
DI 10.2147/NDT.S496172
PG 10
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Psychiatry
GA U8C2R
UT WOS:001414000300001
PM 39897710
OA gold
DA 2025-06-11
ER

PT J
AU Alrefaie, Z
   Ali, SS
   Hamed, EA
AF Alrefaie, Zienab
   Ali, Soad S.
   Hamed, Enas A.
TI Elevated hippocampal mGlut2 receptors in rats with metabolic
   syndrome-induced-memory impairment, possible protection by vitamin D
SO BRAIN RESEARCH BULLETIN
LA English
DT Article
DE Hippocampal synaptic proteins; Metabolic syndrome; MGlut2; Spatial
   memory; Vitamin D
ID LONG-TERM DEPRESSION; COGNITIVE DECLINE; BLOOD-PRESSURE; INDUCTION;
   SNAP-25; LTP; NEUROTOXICITY; ASSOCIATION; EXPRESSION; BRAIN
AB Background: Metabolic syndrome patients are commonly prone to major health problems as cardiovascular diseases, diabetes mellitus, chronic kidney disease, cancer and neuropsychological complications including dementia.Objectives: This research investigates mechanisms linking metabolic syndrome to cognitive impairment and possible impact of vitamin D supplementation.Methods: Forty male Wistar rats were divided into 4 groups. Control, metabolic syndrome (20% fructose solution in drinking water for 12 weeks, vitamin D supplemented (500 IU/kg/day)) and metabolic syndrome supplemented with vitamin D. Animals were assessed for spatial memory, hippocampal expression of SNAP 25, VAMP and mGlut2 receptor and hippocampus histological examination. Animals with metabolic syndrome showed prolonged acquisition and retention latencies in morris water maze, decreased hippocampal expression of SNAP 25 and VAMP and increased mGlut2 expression. Histologically CA1, CA3 regions and dentate nucleus revealed increase in degenerated neurons and glia cells with decreased pyramidal cell layer thickness. Vitamin D supplementation mitigated alterations induced by metabolic syndrome.Conclusions: Metabolic syndrome decreased hippocampal synaptic proteins and altered glutamatergic transmission and increased hippocampal neuronal degeneration. Vitamin D supplementation offered neuroprotective effects.
C1 [Alrefaie, Zienab] King Abdulaziz Univ, Med Physiol Dept, Fac Med, Jeddah, Saudi Arabia.
   [Alrefaie, Zienab] Cairo Univ, Fac Med, Med Physiol Dept, Cairo, Egypt.
   [Ali, Soad S.] King Abdulaziz Univ, Fac Med, Anat Dept, Jeddah, Saudi Arabia.
   [Hamed, Enas A.] Assiut Univ, Fac Med, Med Physiol Dept, Assiut, Egypt.
C3 King Abdulaziz University; Egyptian Knowledge Bank (EKB); Cairo
   University; King Abdulaziz University; Egyptian Knowledge Bank (EKB);
   Assiut University
RP Hamed, EA (corresponding author), Assiut Univ, Fac Med, Dept Med Physiol, POB 71516, Assiut, Egypt.
EM eah3a2010@aun.edu.eg
RI Ali, Soad/J-7708-2012; Alrefaie, Zienab/K-7678-2014
OI Alrefaie, Zienab/0000-0002-9050-9198
FU Deanship of Scientific Research (DSR) at King Abdulaziz University,
   Jeddah, Saudi Arabia [G: 234-248-1441]
FX Acknowledgement This project was funded by the Deanship of Scientific
   Research (DSR) at King Abdulaziz University, Jeddah, Saudi Arabia under
   Grant number [G: 234-248-1441] . The authors, therefore, acknowledge
   with thanks DSR for technical and financial support.
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NR 57
TC 2
Z9 2
U1 1
U2 5
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0361-9230
EI 1873-2747
J9 BRAIN RES BULL
JI Brain Res. Bull.
PD MAR
PY 2022
VL 180
BP 108
EP 117
DI 10.1016/j.brainresbull.2022.01.002
EA JAN 2022
PG 10
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 0W0TL
UT WOS:000788750600002
PM 35026347
DA 2025-06-11
ER

PT J
AU Vitale, E
   Rizzo, A
   Santa, K
   Jirillo, E
AF Vitale, Elsa
   Rizzo, Alessandro
   Santa, Kazuki
   Jirillo, Emilio
TI Associations between "Cancer Risk", "Inflammation" and "Metabolic
   Syndrome": A Scoping Review
SO BIOLOGY-BASEL
LA English
DT Review
DE cancer risk; inflammation; metabolic syndrome; oncogenesis; oxidative
   stress
ID FATTY LIVER-DISEASE; PROSTATE-CANCER; INSULIN-RESISTANCE;
   DIABETES-MELLITUS; COLORECTAL-CANCER; OXIDATIVE STRESS; OBESITY; BREAST;
   EPIDEMIOLOGY; MECHANISMS
AB Simple Summary Individuals with metabolic syndrome exhibit simultaneously pro-thrombotic and a pro-inflammatory conditions which more probably can lead to cardiovascular disease progression, type 2 diabetes mellitus, and some types of cancer. The present scoping review is aimed at highlighting any relations between cancer risk, inflammation, and metabolic syndrome. A total of 20 manuscripts were identified and, among them, we identified some associations with breast cancer, colorectal cancer, esophageal adenocarcinoma, hepatocellular carcinoma (HCC), and cancer in general. Therefore, it could be deducted that cancer and its related progression may also depend on a latent chronic inflammatory condition associated with other concomitant conditions, including type 2 diabetes mellitus, metabolic syndrome, and obesity. Therefore, prevention may potentially help individuals to protect themselves from cancer.Abstract Background: Individuals with metabolic syndrome exhibit simultaneously pro-thrombotic and pro-inflammatory conditions which more probably can lead to cardiovascular diseases progression, type 2 diabetes mellitus, and some types of cancer. The present scoping review is aimed at highlighting the association between cancer risk, inflammation, and metabolic syndrome. Methods: A search strategy was performed, mixing keywords and MeSH terms, such as "Cancer Risk", "Inflammation", "Metabolic Syndrome", "Oncogenesis", and "Oxidative Stress", and matching them through Boolean operators. A total of 20 manuscripts were screened for the present study. Among the selected papers, we identified some associations with breast cancer, colorectal cancer, esophageal adenocarcinoma, hepatocellular carcinoma (HCC), and cancer in general. Conclusions: Cancer and its related progression may also depend also on a latent chronic inflammatory condition associated with other concomitant conditions, including type 2 diabetes mellitus, metabolic syndrome, and obesity. Therefore, prevention may potentially help individuals to protect themselves from cancer.
C1 [Vitale, Elsa] IRCCS, Sci Directorate, Ist Tumori Giovanni Paolo II, Viale Orazio Flacco 65, I-70124 Bari, Italy.
   [Rizzo, Alessandro] IRCCS, Med Oncol, Ist Tumori Giovanni Paolo II, Viale Orazio Flacco 65, I-70124 Bari, Italy.
   [Santa, Kazuki] Juntendo Univ, Fac Med Sci, 6-8-1 Hinode, Urayasu, Chiba 2790013, Japan.
   [Jirillo, Emilio] Univ Bari, Scuola Med, I-70121 Bari, Italy.
C3 IRCCS Istituto Tumori Bari Giovanni Paolo II; IRCCS Istituto Tumori Bari
   Giovanni Paolo II; Juntendo University; Universita degli Studi di Bari
   Aldo Moro
RP Vitale, E (corresponding author), IRCCS, Sci Directorate, Ist Tumori Giovanni Paolo II, Viale Orazio Flacco 65, I-70124 Bari, Italy.
EM e.vitale@oncologico.bari.it; a.rizzo@oncologico.bari.it;
   k-santa@juntendo.ac.jp; emilio.jirillo@uniba.it
RI Rizzo, Alessandro/AAD-8360-2022; Santa, Kazuki/Y-6204-2019; Vitale,
   Elsa/D-8904-2018
OI Santa, Kazuki/0000-0003-2066-1407; Rizzo, Alessandro/0000-0002-5257-8678
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NR 99
TC 26
Z9 26
U1 15
U2 17
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2079-7737
J9 BIOLOGY-BASEL
JI Biology-Basel
PD MAY
PY 2024
VL 13
IS 5
AR 352
DI 10.3390/biology13050352
PG 20
WC Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics
GA SF6Q5
UT WOS:001233085300001
PM 38785834
OA gold
DA 2025-06-11
ER

PT J
AU Damiri, B
   Abualsoud, MS
   Samara, AM
   Salameh, SK
AF Damiri, Basma
   Abualsoud, Mohammed S.
   Samara, Amjad M.
   Salameh, Sakhaa K.
TI Metabolic syndrome among overweight and obese adults in Palestinian
   refugee camps
SO DIABETOLOGY & METABOLIC SYNDROME
LA English
DT Article
DE Metabolic syndrome; Obesity and overweight; Adults
ID PSYCHOLOGICAL STRESS; LIFE-STYLE; PROVISIONAL REPORT; PREVALENCE;
   DEFINITION; DIAGNOSIS; COMPONENTS; IMPACT; FAT
AB Background: Metabolic syndrome (MetS) is one of the main reasons for elevated cardiovascular morbidity and mortality worldwide. Obese and overweight individuals are at high risk of developing these chronic diseases. The aim of this study was to characterize and establish sex-adjusted prevalence of metabolic syndrome and its components.
   Methods: A cross-sectional study was conducted in 2015, 689 (329 men and 360 women) aged 18-65 years from three refugee camps in the West Bank. International Diabetes Federation and modified National Cholesterol Education Program-Third Adult Treatment Panel definitions were used to identify MetS.
   Results: The overall prevalence of obesity and overweight was high, 63.1%; Obesity (42 and 29.2% in women men; respectively and overweight 25.8 and 28.9% in women and men; respectively. The prevalence of MetS among obese and overweight was significantly higher (69.4%) according to IDF than NCEP definition (52%) (p < 0.002) with no significant differences between men and women using both definitions; (IDF; 71.8% men vs. 67.6% women, and (NCEP/ATP III; 51.9% men vs. 52.2% women). The prevalence of MetS increased significantly with increasing obesity and age when NCEP criterion is applied but not IDF. The prevalence of individual MetS components was: high waist circumference 81.3% according to IDF and 56.5% according to NCEP, elevated FBS 65.3% according to IDF and 56% according to NCEP, elevated blood pressure 48%, decreased HDL 65.8%, and elevated triglycerides 31.7%. Based on gender differences, waist circumferences were significantly higher in women according to both criteria and only elevated FBS was higher in women according to IDF criteria. Physical activity was inversely associated with MetS prevalence according to NCEP but not IDF. No significant associations were found with gender, smoking, TV watching, and family history of hypertension or diabetes mellitus.
   Conclusion: In this study, irrespective of the definition used, metabolic syndrome is highly prevalent in obese and overweight Palestinian adults with no gender-based differences. The contribution of the metabolic components to the metabolic syndrome is different in men and women. With the increase of age and obesity, the clustering of metabolic syndrome components increased remarkably. More attention through health care providers should, therefore, be given to the adult population at risk to reduce adulthood obesity and subsequent cardiovascular diseases.
C1 [Damiri, Basma] An Najah Natl Univ, Med & Hlth Sci Fac, Drug & Toxicol Div, Post Box 7, Nablus 0970, West Bank, Palestine.
   [Abualsoud, Mohammed S.; Samara, Amjad M.; Salameh, Sakhaa K.] An Najah Natl Univ, Dept Med, Nablus 0970, Palestine.
C3 An Najah National University; An Najah National University
RP Damiri, B (corresponding author), An Najah Natl Univ, Med & Hlth Sci Fac, Drug & Toxicol Div, Post Box 7, Nablus 0970, West Bank, Palestine.
EM bdamiri@najah.edu
RI Samara, Amjad/V-1704-2019; Damiri, Basma/AAA-3348-2019
OI Damiri, Basma/0000-0001-8242-391X
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NR 58
TC 24
Z9 26
U1 3
U2 10
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1758-5996
J9 DIABETOL METAB SYNDR
JI Diabetol. Metab. Syndr.
PD APR 19
PY 2018
VL 10
AR 34
DI 10.1186/s13098-018-0337-2
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA GD3VU
UT WOS:000430432700002
PM 29713387
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Kamezaki, F
   Sonoda, S
   Nakata, S
   Okazaki, M
   Tamura, M
   Abe, H
   Takeuchi, M
   Otsuji, Y
AF Kamezaki, Fumihiko
   Sonoda, Shinjo
   Nakata, Sei
   Okazaki, Masahiro
   Tamura, Masahito
   Abe, Haruhiko
   Takeuchi, Masaaki
   Otsuji, Yutaka
TI Elevated Depressive Symptoms are Associated with Hypertriglyceridemia in
   Japanese Male Workers
SO INTERNAL MEDICINE
LA English
DT Article
DE depressive symptom; hypertriglyceridemia; Zung self-rating depression
   scale; metabolic syndrome
ID METABOLIC SYNDROME; RISK; MORTALITY; OMEGA-3-FATTY-ACIDS; VALIDITY
AB Objective The aim of this study was to determine whether elevated depressive symptoms are associated with metabolic syndrome and its components in the Japanese population.
   Methods Out of 1,386 male workers who underwent measurements of variables of metabolic syndrome components in their health checkup, 1,186 subjects (44.5 +/- 9.6 years) completed the Zung self-rating depression scale (ZSDS) (response rate 85.6%). In this study, metabolic syndrome was defined according to the joint scientific statement proposed by 6 major organizations, including the International Diabetes Federation.
   Results The overall frequency of elevated depressive symptoms (ZSDS scores >= 40) was 42.1% (n=499). The incidence of metabolic syndrome was significantly higher in subjects with elevated depressive symptoms than in those without (13.2% vs. 8.9%, p<0.05). Of all the metabolic syndrome components, mean triglyceride levels were significantly higher in subjects with elevated depressive symptoms than in those without [124.7 (95% confidence interval (CI): 117.8-131.7) mg/dL vs. 111.5 (95% CI: 107.2-115.9) mg/dL, p<0.05]. Consequently, hypertriglyceridemia (28.9% vs. 21.0%, p<0.01) was the main component correlated with the between-group difference of metabolic syndrome incidence. In the logistic regression analysis after adjustment for potential confounders, the odds ratio of the total ZSDS scores for the diagnosis of hypertriglyceridemia was 1.52 (95% CI: 1.13-2.04; p<0.01), and the major depressive symptom was psychomotor agitation (odds ratio: 1.47; 95% CI: 1.10-1.94; p<0.01).
   Conclusion This study showed that elevated depressive symptoms were associated with hypertriglyceridemia in Japanese male workers, which affected the clinical diagnosis of metabolic syndrome.
C1 [Kamezaki, Fumihiko; Sonoda, Shinjo; Nakata, Sei; Okazaki, Masahiro; Tamura, Masahito; Abe, Haruhiko; Takeuchi, Masaaki; Otsuji, Yutaka] Univ Occupat & Environm Hlth, Sch Med, Dept Internal Med 2, Tokyo, Japan.
   [Kamezaki, Fumihiko] Japan Atom Energy Agcy, Tokai Res & Dev Ctr, Nucl Sci Res Inst, Tokyo, Japan.
C3 University of Occupational & Environmental Health - Japan; Japan Atomic
   Energy Agency
RP Sonoda, S (corresponding author), Univ Occupat & Environm Hlth, Sch Med, Dept Internal Med 2, Tokyo, Japan.
EM s-sonoda@med.uoeh-u.ac.jp
RI Sonoda, Shinjo/AAI-6318-2020
OI Sonoda, Shinjo/0000-0001-5607-9051
FU Ministry of Education, Culture, Sports, Science and Technology, Japan
   [22700706]; Grants-in-Aid for Scientific Research [22700706] Funding
   Source: KAKEN
FX This study was supported in part by a Grant-in-Aid for Young Scientists
   (22700706) from the Ministry of Education, Culture, Sports, Science and
   Technology, Japan.
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NR 28
TC 11
Z9 11
U1 0
U2 1
PU JAPAN SOC INTERNAL MEDICINE
PI TOKYO
PA 34-3 3-CHOME HONGO BUNKYO-KU, TOKYO, 113, JAPAN
SN 0918-2918
EI 1349-7235
J9 INTERNAL MED
JI Intern. Med.
PY 2011
VL 50
IS 21
BP 2485
EP 2490
DI 10.2169/internalmedicine.50.5667
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 880BJ
UT WOS:000299378800007
PM 22041346
OA hybrid
DA 2025-06-11
ER

PT J
AU Tamashiro, KLK
   Hegeman, MA
   Sakai, RR
AF Tamashiro, Kellie L. K.
   Hegeman, Maria A.
   Sakai, Randall R.
TI Chronic social stress in a changing dietary environment
SO PHYSIOLOGY & BEHAVIOR
LA English
DT Article
DE social stress; high fat diet; body weight; body composition; obesity;
   metabolic syndrome
ID CHRONIC PSYCHOSOCIAL STRESS; BODY-FAT DISTRIBUTION; TREE SHREWS; WILD
   BABOON; MALE-RATS; BEHAVIOR; CONSUMPTION; METABOLISM; WEIGHT;
   CONSEQUENCES
AB The human population has slowly transformed from the "hunter-gatherer" period to the current environment of high energy consumption, minimal physical activity and a lifestyle that includes stress and anxiety. Modeling the current environment in the laboratory can help to elucidate mechanisms responsible for the development of obesity, diabetes and, ultimately, the metabolic syndrome. Using the visible burrow system (VBS) model of social stress we have begun to examine the short- and long-term consequences of chronic social stress on energy homeostasis. We demonstrated that social stress has significant effects on body weight and body composition such that subordinate rats progressively develop characteristics of obesity and have additionally determined that this occurs, in part, through changes in food intake amount and behavior. Changes in body weight and body composition are similar or greater when animals are maintained on a high fat diet. These data suggest that consumption of a high-fat diet during social stress in the VBS, while it does not appear to affect development of a social hierarchy, enhances the effect that chronic stress has on body composition and may be more representative of what happens in humans in modem society where the typical diet has progressively moved toward higher calorie, high-fat foods. (c) 2006 Elsevier Inc. All rights reserved.
C1 N Univ Cincinnati, Program Neurosci, Cincinnati, OH 45237 USA.
   N Univ Cincinnati, Dept Psychiat, Cincinnati, OH 45237 USA.
C3 University System of Ohio; University of Cincinnati; University System
   of Ohio; University of Cincinnati
RP Sakai, RR (corresponding author), N Univ Cincinnati, Program Neurosci, 2170 E Galbraith Rd,E-212, Cincinnati, OH 45237 USA.
EM randall.sakai@uc.edu
OI Tamashiro, Kellie/0000-0002-9398-8796
FU NIDDK NIH HHS [R01 DK066596, DK066596] Funding Source: Medline; NINDS
   NIH HHS [NS047791, F31 NS047791] Funding Source: Medline
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NR 53
TC 64
Z9 71
U1 1
U2 26
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0031-9384
J9 PHYSIOL BEHAV
JI Physiol. Behav.
PD NOV 30
PY 2006
VL 89
IS 4
BP 536
EP 542
DI 10.1016/j.physbeh.2006.05.026
PG 7
WC Psychology, Biological; Behavioral Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Behavioral Sciences
GA 112PS
UT WOS:000242539600013
PM 16843504
DA 2025-06-11
ER

PT J
AU Bilska, K
   Dmitrzak-Weglarz, M
   Osip, P
   Pawlak, J
   Paszynska, E
   Permoda-Pachuta, A
AF Bilska, Karolina
   Dmitrzak-Weglarz, Monika
   Osip, Przemyslaw
   Pawlak, Joanna
   Paszynska, Elzbieta
   Permoda-Pachuta, Agnieszka
TI Metabolic Syndrome and Adipokines Profile in Bipolar Depression
SO NUTRIENTS
LA English
DT Article
DE metabolic syndrome; bipolar disorder; adipokines; metformin treatment;
   ADIPO/LEP ratio
ID S100B SERUM-LEVELS; INSULIN-RESISTANCE; ADIPOSE-TISSUE; OBESITY;
   ASSOCIATION; VISFATIN; INDEX
AB Metabolic syndrome (MS) is a growing social, economic, and health problem. MS coexists with nearly half of all patients with affective disorders. This study aimed to evaluate the neurobiological parameters (clinical, anthropometric, biochemical, adipokines levels, and ultrasound of carotid arteries) and their relationship with the development of MS in patients with bipolar disorder. The study group consisted of 70 patients (50 women and 20 men) hospitalized due to episodes of depression in the course of bipolar disorders. The Hamilton Depression Rating Scale was used to assess the severity of the depression symptoms in an acute state of illness and after six weeks of treatment. The serum concentration of adipokines was determined using an ELISA method. The main finding of this study is that the following adipokines correlated with MS in the bipolar depression women group: visfatin, S100B, and leptin had a positive correlation, whereas adiponectin, leptin-receptor, and adiponectin/leptin ratio showed a negative correlation. Moreover, the adiponectin/leptin ratio showed moderate to strong negative correlation with insulin level, BMI, waist circumference, triglyceride level, treatment with metformin, and a positive moderate correlation with HDL. The adiponectin/leptin ratio may be an effective tool to assess MS in depressed female bipolar patients.
C1 [Bilska, Karolina; Dmitrzak-Weglarz, Monika; Pawlak, Joanna] Poznan Univ Med Sci, Dept Psychiat Genet, PL-61701 Poznan, Poland.
   [Osip, Przemyslaw] HCP Med Ctr, PL-61485 Poznan, Poland.
   [Paszynska, Elzbieta] Poznan Univ Med Sci, Dept Integrated Dent, PL-61701 Poznan, Poland.
   [Permoda-Pachuta, Agnieszka] Med Univ Lublin, Dept Psychiat, PL-20059 Lublin, Poland.
C3 Poznan University of Medical Sciences; Poznan University of Medical
   Sciences; Medical University of Lublin
RP Dmitrzak-Weglarz, M (corresponding author), Poznan Univ Med Sci, Dept Psychiat Genet, PL-61701 Poznan, Poland.
EM mweglarz@ump.edu.pl
RI Paszynska, Elzbieta/AAB-8146-2020; Dmitrzak-Weglarz, Monika/C-6674-2011
OI Paszynska, Elzbieta/0000-0001-7135-6264; Bilska,
   Karolina/0000-0001-6777-5829
FU Poznan University of Medical Sciences [502-20-2219-6440(JAK0000131),
   4520]; Department of Integrated Dentistry [JAK000111 (ID 4520)]
FX The work was supported and financed by the Poznan University of Medical
   Sciences from funds allocated for scientific activities for Department
   of Psychiatric Genetics No. 502-20-2219-6440(JAK0000131, ID 4520) and
   Department of Integrated Dentistry No. JAK000111 (ID 4520).
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NR 54
TC 3
Z9 3
U1 1
U2 9
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD NOV
PY 2023
VL 15
IS 21
AR 4532
DI 10.3390/nu15214532
PG 13
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA X7RB5
UT WOS:001100366300001
PM 37960185
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Dean, YE
   Pintado, JJL
   Rouzan, SS
   Nale, LL
   Abbas, A
   Aboushaira, A
   Alkasajy, F
   Ghanem, AA
   Patil, VM
   Gordeyeva, Y
   Motawea, KR
   Le, MLP
   Galal, A
   Cicani, L
   Attta, R
   Soliman, A
   Alzabidi, L
   Subedi, A
   Anjum, N
   Nahedh, A
   Mady, T
   Hazimeh, Y
   Amin, H
   Aiash, H
AF Dean, Yomna E.
   Loayza Pintado, Jose J.
   Rouzan, Samah S.
   Nale, Lucy L.
   Abbas, Ahmed
   Aboushaira, Abdulla
   Alkasajy, Farah
   Ghanem, Ahmed A.
   Patil, Vinayak Mahesh
   Gordeyeva, Yana
   Motawea, Karam R.
   Le, Masako Lien Petty
   Galal, Adham
   Cicani, Laura
   Attta, Raneem
   Soliman, Ahmed
   Alzabidi, Lamya
   Subedi, Anuj
   Anjum, Nikhat
   Nahedh, Abdullah
   Mady, Tamer
   Hazimeh, Yusef
   Amin, Hossam
   Aiash, Hani
TI The Relationship Between Irritable Bowel Syndrome and Metabolic
   Syndrome: A Systematic Review and Meta-Analysis of 49,662 Individuals
SO ENDOCRINOLOGY DIABETES & METABOLISM
LA English
DT Review
DE hypertension; insulin resistance; irritable bowel syndrome; metabolic
   syndrome; obesity
ID GASTROESOPHAGEAL-REFLUX DISEASE; PSYCHOLOGICAL STRESS; ABDOMINAL
   OBESITY; PATHOGENESIS; DYSREGULATION; SYMPTOMS; QUALITY; IMPACT; RISK
AB Background Studies have shown mixed results regarding the association between irritable bowel syndrome (IBS) and metabolic syndrome (MS); This study aimed to assess the susceptibility of IBS patients to MS and its individual components. Methods PubMed, Scopus, Embase, and Web of Science were searched on 1/1/2023. Eligible studies were screened, and data on study characteristics, IBS diagnostic criteria, and metabolic syndrome components were extracted. Data were analysed in RevMan 5.4, with results reported as relative risk (RR) or mean difference (MD) and 95% confidence intervals. Statistical significance was set at p < 0.05. Results IBS was associated with an increased risk of MS (RR = 2.05, 95% CI = 1.50-2.79, p < 0.00001), with a higher risk among IBS-D patients (RR = 3.09, 95% CI = 2.41-3.97, p < 0.00001). IBS patients showed increased HOMA-IR (MD = 0.21, 95% CI = 0.15-0.26, p < 0.00001), higher obesity risk (RR = 1.46, 95% CI = 1.10-1.93, p = 0.009), elevated BMI (MD = 1.51, 95% CI = 0.98-2.03, p-value < 0.00001), waist circumference (MD = 5.01, 95% CI = 1.29-8.72, p = 0.008), and an association with systolic hypertension (MD = -0.50, 95% CI = -0.60 to -0.40, p-value < 0.00001). IBS was also linked to higher LDL (MD = 5.98, 95% CI = 0.91-11.05, p = 0.02), total cholesterol (MD = 12.21, 95% CI = 6.23-18.18, p < 0.0001), and triglycerides (MD = 11.93, 95% CI = 11.55-12.31, p < 0.00001). Conclusions This analysis indicates a potential association between IBS and metabolic syndrome, including its components such as obesity, hypertension, and lipid profile abnormalities. However, significant heterogeneity among studies limits the generalisability of these findings. Clinicians should remain aware of the possible link and consider individualised preventive and management strategies.
C1 [Dean, Yomna E.; Aboushaira, Abdulla; Motawea, Karam R.; Galal, Adham; Attta, Raneem; Nahedh, Abdullah] Alexandria Univ, Fac Med, Alexandria, Egypt.
   [Loayza Pintado, Jose J.; Rouzan, Samah S.] Univ Texas Rio Grande Valley, Mcallen, TX USA.
   [Nale, Lucy L.] Windsor Univ, Sch Med, Basseterre, St Kitts & Nevi.
   [Abbas, Ahmed] Zagazig Univ, Zagazig, Egypt.
   [Alkasajy, Farah] Hashemite Univ, Zarqa, Jordan.
   [Ghanem, Ahmed A.] Mansoura Univ, Fac Med, Mansoura, Egypt.
   [Patil, Vinayak Mahesh] Karnataka Inst Med Sci, Hubli, India.
   [Gordeyeva, Yana; Le, Masako Lien Petty] Poznan Univ Med Sci, Ponzan, Poland.
   [Cicani, Laura] Int Univ Hlth Sci, Basseterre, St Kitts & Nevi.
   [Soliman, Ahmed] Ain Shams Univ, Fac Med, Cairo, Egypt.
   [Alzabidi, Lamya] Sanaa Univ, Fac Med & Hlth Sci, Sanaa, Yemen.
   [Subedi, Anuj] Gorkha Hosp, Gorkha, Nepal.
   [Anjum, Nikhat] Khaja Banda Nawaz Inst Med Sci, Gulbarga, India.
   [Mady, Tamer] Int Amer Univ, Coll Med, St Lucia Campus, Castries, St Lucia.
   [Hazimeh, Yusef] Lebanese Univ, Beirut, Lebanon.
   [Amin, Hossam] New York Acad Med, New York, NY USA.
   [Aiash, Hani] SUNY Upstate Med Univ, Syracuse, NY USA.
C3 Egyptian Knowledge Bank (EKB); Alexandria University; University of
   Texas System; University of Texas Rio Grande Valley; Egyptian Knowledge
   Bank (EKB); Zagazig University; Hashemite University; Egyptian Knowledge
   Bank (EKB); Mansoura University; Poznan University of Medical Sciences;
   Egyptian Knowledge Bank (EKB); Ain Shams University; Lebanese
   University; New York Academy of Medicine; State University of New York
   (SUNY) System; State University of New York (SUNY) Upstate Medical
   Center
RP Hazimeh, Y (corresponding author), Lebanese Univ, Beirut, Lebanon.
EM y.hazimeh@ul.edu.lb
RI Aiash., Hani/ABB-5056-2020; Loayza Pintado, Jose Jonathan/KWU-7658-2024
OI Dean, Yomna/0000-0001-6907-0339
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NR 46
TC 1
Z9 1
U1 1
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
EI 2398-9238
J9 ENDOCRIN DIAB METAB
JI Endocrinol. Diabetes Metab.
PD MAR
PY 2025
VL 8
IS 2
AR e70041
DI 10.1002/edm2.70041
PG 15
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA 0LZ5B
UT WOS:001450547300001
PM 40126935
OA gold
DA 2025-06-11
ER

PT J
AU Mutsatsa, S
   Currid, TJ
AF Mutsatsa, S.
   Currid, T. J.
TI Pharmacogenetics: a reality or misplaced optimism?
SO JOURNAL OF PSYCHIATRIC AND MENTAL HEALTH NURSING
LA English
DT Article
DE depression; drug therapies; medication management; nursing;
   psychopharmacology
ID STEVENS-JOHNSON-SYNDROME; MONOZYGOTIC TWINS CONCORDANT;
   HLA-B-ASTERISK-1502 ALLELE; TARDIVE-DYSKINESIA; HEALTH; CARBAMAZEPINE;
   CLOZAPINE; SCHIZOPHRENIA; ASSOCIATION; NURSE
AB The paper aims to review current evidence that supports the application of genetic information in the management and use of psychotropic medication. Although the importance of an individual's genetic makeup in the metabolism of drugs has been known for at least 50 years, it is only recently that such information is finding clinical application. A literature review of recent studies suggest that there are clear variations in the way people respond to psychotropic medication. These variations can be seen across racial and ethnic lines, and are genetically determined. The hope is that, in future we will be able to use genetic information to predict which patient will benefit from which drug and at what dose. In other fields of health care such as anticoagulant therapy, the application of pharmacogenetics is now established in routine clinical care. Several psychiatric pharmacogenetic tests are currently available, including tests for the determination of metabolic status, risk of agranulocytosis and metabolic syndrome, and selection of beneficial medications. Since nurses are the centrepiece of mental health care, these advances are likely to alter significantly future mental health nurse education and practice.
C1 [Mutsatsa, S.; Currid, T. J.] London S Bank Univ, Fac Hlth & Social Care, Romford RM3 0BE, Essex, England.
C3 London South Bank University
RP Mutsatsa, S (corresponding author), London S Bank Univ, Fac Hlth & Social Care, Gubbins Lane, Romford RM3 0BE, Essex, England.
EM mutsatss@lsbu.ac.uk
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NR 45
TC 9
Z9 14
U1 0
U2 21
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1351-0126
EI 1365-2850
J9 J PSYCHIATR MENT HLT
JI J. Psychiatr. Ment. Health Nurs.
PD APR
PY 2013
VL 20
IS 4
BP 314
EP 320
DI 10.1111/j.1365-2850.2012.01910.x
PG 7
WC Nursing; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Psychiatry
GA 108TN
UT WOS:000316319200006
PM 22512271
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Ivanova, HI
   de Rooij, SR
   Hutten, BA
   Vrijkotte, TGM
AF Ivanova, Hristiyanna I.
   de Rooij, Susanne R.
   Hutten, Barbara A.
   Vrijkotte, Tanja G. M.
TI Psychosocial Problems at Preschool Age and Cardiometabolic Health
   Profile at Preadolescence
SO PSYCHOSOMATIC MEDICINE
LA English
DT Article
DE psychosocial problems; cardiometabolic risk; metabolic profile;
   childhood; adolescence; longitudinal study
ID CARDIOVASCULAR RISK-FACTORS; DIFFICULTIES QUESTIONNAIRE; PSYCHOLOGICAL
   DISTRESS; BEHAVIORAL-PROBLEMS; METABOLIC SYNDROME; DIABETES-MELLITUS;
   EARLY-CHILDHOOD; CHILDREN; ASSOCIATIONS; DEPRESSION
AB Objective Evidence suggests that children with psychosocial problems face a higher risk of cardiometabolic diseases in adulthood. However, this may already be evident prior to adulthood. In this study, the associations between psychosocial problems at preschool age and cardiometabolic outcomes 6 years later were investigated. Methods Data from 936 participants from the Amsterdam Born Children and their Development (ABCD) study was used. Psychosocial problems were assessed using the Strengths & Difficulties Questionnaire (SDQ) when the children were 5-6 years old, reported by both mothers and teachers. Cardiometabolic parameters, including body mass index, waist circumference, total cholesterol, triglycerides, high- and low-density lipoprotein cholesterol, fasting glucose, systolic and diastolic blood pressure, and carotid intima-media thickness were subsequently measured at ages 11-12 years. The associations between psychosocial problems and cardiometabolic outcomes were assessed using multivariable linear and logistic regression models. Results In model 1, adjusted for age, sex, and puberty status, and in model 2, for sociodemographic and biological predisposition factors, the combined mother-teacher score yielded a positive association with clustered cardiometabolic score (b = 0.05, 95% confidence interval = 0.03-0.10) 6 years later. Adjusting for lifestyle factors rendered this association nonsignificant. Significant associations between mother-reported SDQ scores and most cardiometabolic parameters, except for triglycerides, diminished after controlling for confounders. Children with higher total SDQ score (by mother) had 1.31 times higher odds of developing metabolic syndrome (95% confidence interval = 1.05-1.62). Conclusion This study established a small inverse association between mother-reported psychosocial problems at ages 5-6 years and cardiometabolic health profile at ages 11-12 years.
C1 [Ivanova, Hristiyanna I.; Vrijkotte, Tanja G. M.] Amsterdam Publ Hlth Res Inst, Dept Publ & Occupat Hlth, Amsterdam, Netherlands.
   [de Rooij, Susanne R.; Hutten, Barbara A.] Univ Amsterdam, Dept Epidemiol & Data Sci, Amsterdam UMC, Amsterdam, Netherlands.
   [de Rooij, Susanne R.; Vrijkotte, Tanja G. M.] Univ Amsterdam, Reprod & Dev Res Inst, Amsterdam, Netherlands.
   [Hutten, Barbara A.] Univ Amsterdam, Amsterdam Publ Hlth Res Inst, Aging & Later Life Hlth Behav & Chron Dis, Amsterdam UMC, Amsterdam, Netherlands.
C3 Vrije Universiteit Amsterdam; University of Amsterdam; University of
   Amsterdam; Vrije Universiteit Amsterdam; University of Amsterdam
RP Vrijkotte, TGM (corresponding author), Amsterdam UMC, Dept Publ & Occupat Hlth, Boechorststr 7, NL-1081 BT Amsterdam, Netherlands.
EM hristiyannaiv@icloud.com; s.r.derooij@amsterdamumc.nl;
   b.a.hutten@amsterdamumc.nl; t.vrijkotte@amsterdamumc.nl
OI Ivanova, Hristiyanna/0009-0009-0913-5845; Vrijkotte,
   Tanja/0000-0003-3641-4048
FU Netherlands Organization for Health Research and Development (ZonMw);
   Dutch Heart Foundation, and Sarphati Amsterdam
FX All authors declare no conflicts of interests. This study was supported
   bythe Netherlands Organization for Health Research and Development
   (ZonMw), The Dutch Heart Foundation, and Sarphati Amsterdam.
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NR 59
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0033-3174
EI 1534-7796
J9 PSYCHOSOM MED
JI Psychosom. Med.
PD JAN
PY 2025
VL 87
IS 1
BP 46
EP 56
DI 10.1097/PSY.0000000000001353
PG 11
WC Psychiatry; Psychology; Psychology, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry; Psychology
GA P9Z9M
UT WOS:001381407900005
PM 39701569
DA 2025-06-11
ER

PT J
AU Stefanaki, C
   Pervanidou, P
   Boschiero, D
   Chrousos, GP
AF Stefanaki, Charikleia
   Pervanidou, Panagiota
   Boschiero, Dario
   Chrousos, George P.
TI Chronic stress and body composition disorders: implications for health
   and disease
SO HORMONES-INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM
LA English
DT Review
DE Body composition; Stress hormones; Stress physiology; Muscle; Fat; Bone
ID POLYCYSTIC-OVARY-SYNDROME; PITUITARY-ADRENAL AXIS; BONE-MINERAL DENSITY;
   SKELETAL-MUSCLE; OXIDATIVE STRESS; ESSENTIAL-HYPERTENSION; POSITIVE
   ASSOCIATION; DEHYDROGENASE TYPE-1; SARCOPENIC OBESITY;
   INSULIN-RESISTANCE
AB Recent studies have suggested that body composition is key to health and disease. First, fat tissue is a complex, essential, and highly active metabolic and endocrine organ that responds to afferent signals from traditional hormone systems and the central nervous system but also expresses and secretes factors with important endocrine, metabolic, and immune functions. Second, skeletal muscle mass is an important predictor of health in adult life, while severe mass loss has been associated with the frailty of old age. Studies have shown that skeletal muscle is also an important endocrine organ that secretes factors with autocrine, paracrine, or endocrine actions, which have been associated with inflammatory processes. Third, the bone is also a systemic endocrine regulator playing a pivotal role in health and disease. Finally, proper hydration in humans has been neglected as a health factor, especially in adults. Chronic stress and stress hormone hypersecretion alone or associated with distinct disorders, such as anxiety, depression, obesity, metabolic syndrome, autoimmune disorders, type 2 diabetes mellitus, and polycystic ovary syndrome (PCOS), have been associated with psychological and somatic manifestations, typically, increased fat mass, osteosarcopenia/frailty, cellular dehydration, and chronic systemic inflammation. This review aims to provide new insights into the newly developed concept of stress-related osteosarcopenic obesity and its prevention.
C1 [Stefanaki, Charikleia; Pervanidou, Panagiota; Chrousos, George P.] Univ Athens, Med Sch, Dept Pediat 1, Choreme Res Lab, Thivon & Levadeias St, Athens 11527, Greece.
   [Stefanaki, Charikleia; Chrousos, George P.] Univ Athens, Med Sch, Unit Translat & Clin Res Endocrinol, Athens, Greece.
   [Boschiero, Dario] BIOTEKNA Biomed Technol, Venice, Italy.
C3 National & Kapodistrian University of Athens; National & Kapodistrian
   University of Athens
RP Stefanaki, C (corresponding author), Univ Athens, Med Sch, Dept Pediat 1, Choreme Res Lab, Thivon & Levadeias St, Athens 11527, Greece.; Stefanaki, C (corresponding author), Univ Athens, Med Sch, Unit Translat & Clin Res Endocrinol, Athens, Greece.
EM cstefanaki@gmail.com
RI Stefanaki, Charikleia/G-6653-2012; Pervanidou, Panagiota/ABI-6356-2020;
   Chrousos, George/G-8702-2011
OI Pervanidou, Panagiota/0000-0002-6593-6489; Stefanaki,
   Charikleia/0000-0003-1634-701X
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NR 106
TC 79
Z9 90
U1 3
U2 32
PU HELLENIC ENDOCRINE SOC
PI ATHENS
PA 14 ALEXANDRAS AVE, ATHENS, 106 82, GREECE
SN 1109-3099
J9 HORM-INT J ENDOCRINO
JI Horm.-Int. J. Endocrinol. Metab.
PD MAR
PY 2018
VL 17
IS 1
BP 33
EP 43
DI 10.1007/s42000-018-0023-7
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA GH1DD
UT WOS:000433141800006
PM 29858868
OA Bronze
DA 2025-06-11
ER

PT S
AU Tsigos, C
   Chrousos, GP
AF Tsigos, Constantine
   Chrousos, George P.
BE Chrousos, GP
   Tsigos, C
TI Stress, obesity, and the metabolic syndrome - Soul and metabolism
SO STRESS, OBESITY, AND METABOLIC SYNDROME
SE Annals of the New York Academy of Sciences
LA English
DT Article; Proceedings Paper
CT Bjorntorp Symposium on Stress, Obesity, and Metabolic Syndrome
CY APR 09-10, 2005
CL Athens, GREECE
SP Roche Hellas, Abbott Hellas, Pfizer Hellas, Sanofi Aventis Hellas, GlaxoSmithKline Hellas
C1 Univ Athens, Sch Med, Evgenid Hosp, Endocrinol Metab & Diabet Unit, GR-10679 Athens, Greece.
   Hellen Natl Diabet Ctr, Athens, Greece.
   Univ Athens, Sch Med, Dept Pediat 1, Aghia Sophia Childrens Hosp, GR-10679 Athens, Greece.
C3 National & Kapodistrian University of Athens; Athens Medical School; The
   Aghia Sophia Children's Hospital; National & Kapodistrian University of
   Athens; Athens Medical School
RP Tsigos, C (corresponding author), 82 Vas Sophias Ave, GR-11528 Athens, Greece.
EM ctsigos@gmail.com
RI Chrousos, George/G-8702-2011
CR Charmandari E, 2005, ANNU REV PHYSIOL, V67, P259, DOI 10.1146/annurev.physiol.67.040403.120816
   Chrousos GP, 2004, AM J MED, V117, P204, DOI 10.1016/j.amjmed.2004.05.006
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   TSIGOS C, 2005, STRESS MED HLTH, P99
NR 5
TC 5
Z9 8
U1 0
U2 2
PU BLACKWELL SCIENCE PUBL
PI OXFORD
PA OSNEY MEAD, OXFORD OX2 0EL, ENGLAND
SN 0077-8923
BN 978-1-57331-625-5
J9 ANN NY ACAD SCI
JI Ann.NY Acad.Sci.
PY 2006
VL 1083
BP XI
EP XIII
DI 10.1196/annals.1367.025
PG 3
WC Endocrinology & Metabolism; Multidisciplinary Sciences
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Science & Technology - Other Topics
GA BFR90
UT WOS:000244102900001
PM 17216893
DA 2025-06-11
ER

PT J
AU Beyazyüz, M
   Albayrak, Y
   Egilmez, OB
   Albayrak, N
   Beyazyüz, E
AF Beyazyuz, Murat
   Albayrak, Yakup
   Egilmez, Oguzhan Bekir
   Albayrak, Neslihan
   Beyazyuz, Elmas
TI Relationship between SSRIs and Metabolic Syndrome Abnormalities in
   Patients with Generalized Anxiety Disorder: A Prospective Study
SO PSYCHIATRY INVESTIGATION
LA English
DT Article
DE Metabolic syndrome; SSRI; Side effect; Prospective; Anxiety
ID SEROTONIN REUPTAKE INHIBITORS; DEPRESSIVE SYMPTOMS; CHOLESTEROL LEVELS;
   PHYSICAL-ACTIVITY; WEIGHT; PREVALENCE; HEALTH; RISK; ASSOCIATION;
   FLUOXETINE
AB Objective SSRIs are some of the most widely prescribed medications in the world. In addition to their effectiveness, SSRIs were reported to be associated with the side effects of weight gain, sexual dysfunction, drug interactions, extrapyramidal symptoms and discontinuation symptoms. However, the effects of SSRIs on metabolic parameters are poorly understood.
   Methods This study aims to describe the effects of SSRIs on the metabolic parameters of drug-naive first episode patients with generalized anxiety disorder. Ninety-seven female patients aged 20-41 years without any metabolic or psychiatric comorbidity were included in the study. Fluoxetine, sertraline, paroxetine, citalopram and escitalopram were randomly given to the patients. Metabolic parameters, including BMI, waist circumference and the levels of fasting glucose, total cholesterol, triglyceride, HDL, LDL and blood pressure, were measured before and after 16 weeks of treatment.
   Results In the paroxetine group, there was a significant increase in the parameters of weight, BMI, waist circumference, fasting glucose, total cholesterol, LDL and triglyceride after 16 weeks of treatment There were significant increases in the levels of triglyceride in the citalopram and escitalopram groups. In the sertraline group, the total cholesterol level increased after treatment. In the fluoxetine group, there were significant reductions in the parameters of weight, total cholesterol and triglyceride.
   Conclusion To our knowledge, this study is the first to prospectively describe metabolic syndrome abnormalities in patients with first episode generalized anxiety disorder. Although the effectiveness of the different SSRIs is similar, clinicians should be more careful when prescribing SSRIs to patients who have cardiac risk factors. Larger and lengthier controlled clinical trials are needed to explore the associations between SSRI use and metabolic syndrome.
C1 [Beyazyuz, Murat] Golbasi Hasvak State Hosp, Dept Psychiat, Ankara, Turkey.
   [Albayrak, Yakup] Kirklareli State Hosp, Dept Psychiat, TR-3901 Kirklareli, Turkey.
   [Egilmez, Oguzhan Bekir] Adiyaman State Hosp, Dept Psychiat, Adiyaman, Turkey.
   [Albayrak, Neslihan] Kirklareli State Hosp, Dept Cardiol, TR-3901 Kirklareli, Turkey.
   [Beyazyuz, Elmas] Ankara Numune Training & Res Hosp, Dept Psychiat, Ankara, Turkey.
C3 Golbasi Hasvak State Hospital; Adiyaman State Hospital; Ankara Numune
   Training & Research Hospital
RP Albayrak, Y (corresponding author), Kirklareli Devlet Hastanesi, Dept Psychiat, Psikiyatri Klin, TR-3901 Kirklareli, Turkey.
EM dr.fuge@hotmail.com
RI BEYAZYUZ, MURAT/ABA-7934-2020; BEYAZYÜZ, Elmas/ABA-7951-2020; Albayrak,
   Yakup/ABA-7651-2020; EGİLMEZ, OĞUZHAN BEKİR/HLG-1918-2023
OI BEYAZYUZ, MURAT/0000-0002-5770-344X; Egilmez, Oguzhan
   Bekir/0000-0002-6303-1758; Beyazyuz, Elmas/0000-0001-5680-0101
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NR 53
TC 63
Z9 70
U1 1
U2 27
PU KOREAN NEUROPSYCHIATRIC ASSOC
PI SEOUL
PA RN 522, G-FIVE CENTRAL PLAZA 1685-8 SEOCHO 4-DONG, SEOCHO-GU, SEOUL,
   137-882, SOUTH KOREA
EI 1976-3026
J9 PSYCHIAT INVEST
JI Psychiatry Investig.
PD JUN
PY 2013
VL 10
IS 2
BP 148
EP 154
DI 10.4306/pi.2013.10.2.148
PG 7
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 172AS
UT WOS:000320972900008
PM 23798963
OA Green Published, hybrid, Green Submitted
DA 2025-06-11
ER

PT J
AU Libowitz, MR
   Nurmi, EL
AF Libowitz, Mark R.
   Nurmi, Erika L.
TI The Burden of Antipsychotic-Induced Weight Gain and Metabolic Syndrome
   in Children
SO FRONTIERS IN PSYCHIATRY
LA English
DT Review
DE child psychiatry; pediatrics; antipsychotics; antipsychotic-induced
   weight gain; adverse drug effects; metabolic syndrome
ID EARLY-ONSET SCHIZOPHRENIA; BETAHISTINE CO-TREATMENT; SEVERE
   MENTAL-ILLNESS; 5-HT2C RECEPTOR GENE; ATYPICAL ANTIPSYCHOTICS;
   LONG-TERM; DOUBLE-BLIND; BODY-WEIGHT; 2ND-GENERATION ANTIPSYCHOTICS; GUT
   MICROBIOME
AB Antipsychotic medications are critical to child and adolescent psychiatry, from the stabilization of psychotic disorders like schizophrenia, bipolar disorder, and psychotic depression to behavioral treatment of autism spectrum disorder, tic disorders, and pediatric aggression. While effective, these medications carry serious risk of adverse events-most commonly, weight gain and cardiometabolic abnormalities. Negative metabolic consequences affect up to 60% of patients and present a major obstacle to long-term treatment. Since antipsychotics are often chronically prescribed beginning in childhood, cardiometabolic risk accumulates. An increased susceptibility to antipsychotic-induced weight gain (AIWG) has been repeatedly documented in children, particularly rapid weight gain. Associated cardiometabolic abnormalities include central obesity, insulin resistance, dyslipidemia, and systemic inflammation. Lifestyle interventions and medications such as metformin have been proposed to reduce risk but remain limited in efficacy. Furthermore, antipsychotic medications touted to be weight-neutral in adults can cause substantial weight gain in children. A better understanding of the biological underpinnings of AIWG could inform targeted and potentially more fruitful treatments; however, little is known about the underlying mechanism. As yet, modest genetic studies have nominated a few risk genes that explain only a small percentage of the risk. Recent investigations have begun to explore novel potential mechanisms of AIWG, including a role for gut microbiota and microbial metabolites. This article reviews the problem of AIWG and AP metabolic side effects in pediatric populations, proposed mechanisms underlying this serious side effect, and strategies to mitigate adverse impact. We suggest future directions for research efforts that may advance the field and lead to improved clinical interventions.
C1 [Libowitz, Mark R.; Nurmi, Erika L.] Univ Calif Los Angeles, Dept Psychiat & Biobehav Sci, Semel Inst Neurosci & Human Behav, Los Angeles, CA 90095 USA.
C3 University of California System; University of California Los Angeles
RP Nurmi, EL (corresponding author), Univ Calif Los Angeles, Dept Psychiat & Biobehav Sci, Semel Inst Neurosci & Human Behav, Los Angeles, CA 90095 USA.
EM enurmi@g.ucla.edu
RI Nurmi, Erika/AAX-1625-2020
OI Libowitz, Mark/0000-0002-6143-772X
FU NICHD [R21 HD095548-01]
FX This work was supported by the NICHD R21 HD095548-01.
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NR 318
TC 47
Z9 48
U1 2
U2 30
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-0640
J9 FRONT PSYCHIATRY
JI Front. Psychiatry
PD MAR 12
PY 2021
VL 12
AR 623681
DI 10.3389/fpsyt.2021.623681
PG 24
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA RC2KV
UT WOS:000632634300001
PM 33776816
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Mozhey, OI
   Zatolokin, PA
   Vasilenko, MA
   Litvinova, LS
   Kirienkova, EV
   Mazunin, IO
AF Mozhey, O. I.
   Zatolokin, P. A.
   Vasilenko, M. A.
   Litvinova, L. S.
   Kirienkova, E. V.
   Mazunin, I. O.
TI Evaluating the number of mitochondrial DNA copies in leukocytes and
   adipocytes from metabolic syndrome patients: Pilot study
SO MOLECULAR BIOLOGY
LA English
DT Article
DE metabolic syndrome; body mass index; mitochondrial DNA number of copies;
   adipocytes
ID OXIDATIVE STRESS; ADIPOSE-TISSUE; COPY NUMBER; DYSFUNCTION; BIOGENESIS
AB Metabolic syndrome is a complex of metabolic, hormonal, and clinical disorders. Defects in mitochondrial functions play an important role in the metabolic syndrome pathogenesis. Here, variations in the number of mitochondrial DNA (mtDNA) copies were evaluated in different fat-tissue and peripheral-blood-leukocyte samples from metabolic syndrome patients ranked by body mass indices. The number of mtDNA copies showed a tendency to decrease with increase body mass index.
C1 [Mozhey, O. I.; Kirienkova, E. V.; Mazunin, I. O.] Immanuel Kant Balt Fed Univ, Inst Med, Kaliningrad 236016, Russia.
   [Zatolokin, P. A.] Kaliningrad Reg Hosp, Dept Reconstruct & Endoscop Surg, Kaliningrad 236016, Russia.
   [Mozhey, O. I.; Vasilenko, M. A.; Litvinova, L. S.; Kirienkova, E. V.; Mazunin, I. O.] Immanuel Kant Balt Fed Univ, Kaliningrad 236016, Russia.
C3 Immanuel Kant Baltic Federal University; Immanuel Kant Baltic Federal
   University
RP Mozhey, OI (corresponding author), Immanuel Kant Balt Fed Univ, Inst Med, Kaliningrad 236016, Russia.
EM IMazunin@kantiana.ru
RI Mazunin, Ilya/KWU-4661-2024; Mozhei, Oleg/S-4758-2016; Kirienkova,
   Elena/B-2164-2014; Vulf, Maria/E-4926-2017; Litvinova,
   Larisa/A-9672-2014
OI Kirienkova, Elena/0000-0002-5980-3321; Mozhei, Oleg/0000-0002-5427-1688;
   Mazunin, Ilya/0000-0002-5448-9679; Vulf, Maria/0000-0002-4989-045X;
   Litvinova, Larisa/0000-0001-5231-6910
FU Federal Purpose Program "Scientific and Educational Personnel of the
   Innovative Russia" [P329, 14.A18.21.1518]
FX The authors are grateful to Yu.Yu. Il'inskii (Institute of Cytology and
   Genetics, Siberian Branch, Russian Academy of Sciences) for his critical
   reading of the manuscript. The work was financially supported by the
   Federal Purpose Program "Scientific and Educational Personnel of the
   Innovative Russia" for 2009-2013 (state contract no. P329, and contract
   no. 14.A18.21.1518).
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NR 21
TC 7
Z9 7
U1 0
U2 7
PU MAIK NAUKA/INTERPERIODICA/SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013-1578 USA
SN 0026-8933
EI 1608-3245
J9 MOL BIOL+
JI Mol. Biol.
PD JUL
PY 2014
VL 48
IS 4
BP 590
EP 593
DI 10.1134/S0026893314040074
PG 4
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA AN6BY
UT WOS:000340679900012
DA 2025-06-11
ER

PT J
AU Siegrist, J
   Li, J
AF Siegrist, Johannes
   Li, Jian
TI Work Stress and Altered Biomarkers: A Synthesis of Findings Based on the
   Effort-Reward Imbalance Model
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Review
DE effort-reward imbalance; over-commitment; biomarkers; work stress;
   narrative review
ID HEART-RATE-VARIABILITY; WHITE-COLLAR WORKERS; AMBULATORY BLOOD-PRESSURE;
   ACUTE PSYCHOSOCIAL STRESS; ALLOSTATIC LOAD INDEX; HPA AXIS RESPONSES;
   METABOLIC SYNDROME; JOB STRESS; SCHOOL TEACHERS; RISK-FACTORS
AB While epidemiological studies provide statistical evidence on associations of exposures such as stressful work with elevated risks of stress-related disorders (e.g., coronary heart disease or depression), additional information on biological pathways and biomarkers underlying these associations is required. In this contribution, we summarize the current state of the art on research findings linking stressful work, in terms of an established theoretical modeleffort-reward imbalancewith a broad range of biomarkers. Based on structured electronic literature search and recent available systematic reviews, our synthesis of findings indicates that associations of work stress with heart rate variability, altered blood lipids, and risk of metabolic syndrome are rather consistent and robust. Significant relationships with blood pressure, heart rate, altered immune function and inflammation, cortisol release, and haemostatic biomarkers were also observed, but due to conflicting findings additional data will be needed to reach a firm conclusion. This narrative review of empirical evidence supports the argument that the biomarkers under study can act as mediators of epidemiologically established associations of work stress, as measured by effort-reward imbalance, with incident stress-related disorders.
C1 [Siegrist, Johannes] Univ Dusseldorf, Life Sci Ctr, Merowingerpl 1a, D-40225 Dusseldorf, Germany.
   [Li, Jian] Univ Dusseldorf, Inst Occupat Social & Environm Med, Ctr Hlth & Soc, Fac Med, Univ Str 1, D-40225 Dusseldorf, Germany.
C3 Heinrich Heine University Dusseldorf; Heinrich Heine University
   Dusseldorf
RP Siegrist, J (corresponding author), Univ Dusseldorf, Life Sci Ctr, Merowingerpl 1a, D-40225 Dusseldorf, Germany.
EM johannes.siegrist@med.uni-duesseldorf.de; jian.li@uni-duesseldorf.de
RI Siegrist, Johannes/AAL-6814-2021
OI Siegrist, Johannes/0000-0002-7530-4178
FU Faculty of Medicine, University of Dusseldorf, Germany
FX Johannes Siegrist was supported by a Senior Professorship grant from the
   Faculty of Medicine, University of Dusseldorf, Germany.
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NR 122
TC 67
Z9 82
U1 2
U2 36
PU MDPI AG
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD NOV
PY 2017
VL 14
IS 11
AR 1373
DI 10.3390/ijerph14111373
PG 18
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA FO1SQ
UT WOS:000416545200089
PM 29125555
OA Green Submitted, gold, Green Published
DA 2025-06-11
ER

PT J
AU Kittel, JA
   DeBeer, BB
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   Matthieu, MM
   Meyer, EC
   Gulliver, SB
   Morissette, SB
AF Kittel, Julie A.
   DeBeer, Bryann B.
   Kimbrel, Nathan A.
   Matthieu, Monica M.
   Meyer, Eric C.
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   Morissette, Sandra B.
TI Does body mass index moderate the association between posttraumatic
   stress disorder symptoms and suicidal ideation in Iraq/Afghanistan
   veterans?
SO PSYCHIATRY RESEARCH
LA English
DT Article
ID MENTAL-HEALTH-CARE; SOCIAL SUPPORT; METABOLIC SYNDROME;
   GENERAL-POPULATION; AFRICAN-AMERICAN; BIPOLAR-DISORDER; ACTIVE-DUTY;
   RISK-FACTOR; FOLLOW-UP; OBESITY
AB Suicide, PTSD, and obesity co-occur at high rates among returning veterans, yet limited research exists regarding the relationship among these variables. Self-report and diagnostic interview data from a longitudinal study of Iraq and Afghanistan veterans (N=130) enrolled in VA healthcare examined these inter-relations. As hypothesized, body mass index (BMI) significantly moderated the association between PTSD and suicidal ideation such that the association between PTSD and suicidal ideation was strongest among individuals with a high BMI. Programs that focus on health promotion, trauma treatment, and weight management should continue to monitor suicide risk. Published by Elsevier Ireland Ltd.
C1 [Kittel, Julie A.; DeBeer, Bryann B.; Meyer, Eric C.] VISN 17 Ctr Excellence Res Returning War Vet, Dept Vet Affairs, Waco, TX USA.
   [DeBeer, Bryann B.; Meyer, Eric C.; Gulliver, Suzy Bird] Texas A&M Univ, College Stn, TX USA.
   [Kimbrel, Nathan A.] Durham Vet Affairs Med Ctr, Durham, NC USA.
   [Kimbrel, Nathan A.] VA Midatlantic Mental Illness Res Educ & Clin Ctr, Durham, NC USA.
   [Kimbrel, Nathan A.] Duke Univ, Sch Med, Durham, NC USA.
   [Matthieu, Monica M.] St Louis Univ, Coll Publ Hlth & Social Justice, Sch Social Work, St Louis, MO 63103 USA.
   [Matthieu, Monica M.] Cent Arkansas VA Healthcare Syst, VA Mental Hlth QUERI, Patient Safety Ctr Inquiry Suicide Prevent, North Little Rock, AR USA.
   [Matthieu, Monica M.] Cent Arkansas VA Healthcare Syst, Mental Hlth Serv, North Little Rock, AR USA.
   [Gulliver, Suzy Bird] Baylor Scott & White Hlth, Warriors Res Inst, Waco, TX USA.
   [Morissette, Sandra B.] Univ Texas San Antonio, Dept Psychol, San Antonio, TX USA.
C3 Texas A&M University System; Texas A&M University College Station; US
   Department of Veterans Affairs; Veterans Health Administration (VHA);
   Durham VA Medical Center; Duke University; Saint Louis University;
   Baylor Health Care System; University of Texas System; University of
   Texas at San Antonio (UTSA)
RP Kittel, JA (corresponding author), VA VISN 17 Ctr Excellence Res Returning War Vet, 4800 Vet Mem Dr,151C, Waco, TX 76711 USA.
EM Julie.kittel@va.gov
RI Gulliver, Suzy/X-9776-2019; Meyer, Eric/GYV-3448-2022; Kittel,
   Julie/U-7880-2019; Kimbrel, Nathan/P-3109-2016
OI Gulliver, Suzy Bird/0000-0002-6476-9447; Kimbrel,
   Nathan/0000-0001-7218-1005
FU Rehabilitation Research and Development Service of the VA Office of
   Research and Development (ORD) [I01RX000304]; Clinical Sciences Research
   and Development Service of VA ORD [IK2 CX000525]; Department of Veterans
   Affairs VISN 17 Center of Excellence for Research on Returning War
   Veterans, Central Texas Veterans Health Care System; Mental Health QUERI
   at the Central Arkansas Healthcare System; Patient Safety Center of
   Inquiry on Suicide Prevention at the Central Arkansas Healthcare System
FX This research was supported by a VA Merit Award #I01RX000304 to Dr.
   Morissette from the Rehabilitation Research and Development Service of
   the VA Office of Research and Development (ORD), a Career Development
   Award (IK2 CX000525) to Dr. Kimbrel from Clinical Sciences Research and
   Development Service of VA ORD, the Department of Veterans Affairs VISN
   17 Center of Excellence for Research on Returning War Veterans, Central
   Texas Veterans Health Care System, and the Mental Health QUERI and the
   Patient Safety Center of Inquiry on Suicide Prevention at the Central
   Arkansas Healthcare System. The views expressed in this article are
   those of the authors and do not necessarily reflect the position or
   policy of VA, the United States government, universities, or other
   affiliates.
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NR 71
TC 6
Z9 7
U1 0
U2 22
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0165-1781
J9 PSYCHIAT RES
JI Psychiatry Res.
PD OCT 30
PY 2016
VL 244
BP 123
EP 129
DI 10.1016/j.psychres.2016.07.039
PG 7
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA DY0HA
UT WOS:000384776700020
PM 27479102
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Kazaz, I
   Angin, E
   Kabaran, S
   Iyigün, G
   Kirmizigil, B
   Malkoç, M
AF Kazaz, Ismet
   Angin, Ender
   Kabaran, Seray
   Iyiguen, Gozde
   Kirmizigil, Berkiye
   Malkoc, Mehtap
TI Evaluation of the physical activity level, nutrition quality, and
   depression in patients with metabolic syndrome: Comparative study
SO MEDICINE
LA English
DT Article
DE depression; metabolic syndrome; nutrition; physical activity; public
   health
ID CARDIOVASCULAR RISK-FACTORS; LIFE-STYLE INTERVENTION; MEDITERRANEAN
   DIET; ACTIVITY QUESTIONNAIRE; ABDOMINAL OBESITY; ADULTS; HEALTH;
   ADHERENCE; PREVALENCE; RELIABILITY
AB Metabolic syndrome (MetS) is a complex problem that contains risk factors related with obesity, cardiovascular diseases, and type-II diabetes. The incidence of MetS is increasing every year throughout the world.The aim of this study was to evaluate and compare physical activity levels, nutrition quality, and depression status of the individuals who are diagnosed with and without MetS.International Physical Activity Questionnaire (IPAQ), Mediterranean Diet Adherence Screener (MEDAS), Beck Depression Inventory (BDI) was used. In addition, biochemical analysis and anthropometric measurements were also taken.According to IPAQ, 81.1% of the MetS group is inactive, 6.8% is active, and 5.1% is highly active, whereas 22.3% of the non-MetS group is inactive, 46.2% is active, and 31.5% is highly active. MEDAS was found to be lower in the MetS group. BDI levels were also determined high in the MetS group.Sedentary lifestyle, depression, and unhealthy nutrition habits are among the significant factors for the development of MetS. The knowledge levels of the people should be increased by developing national physical activity and nutrition guidelines.
C1 [Kazaz, Ismet] Eastern Mediterranean Univ, Physiotherapy & Rehabil Dept, Fac Hlth Sci, Via Mersin 10, Famagusta, North Cyprus, Turkey.
   [Angin, Ender; Kabaran, Seray; Iyiguen, Gozde; Kirmizigil, Berkiye; Malkoc, Mehtap] Eastern Mediterranean Univ, Nutr & Dietet Dept, Fac Hlth Sci, Via Mersin 10, Famagusta, North Cyprus, Turkey.
C3 Eastern Mediterranean University; Eastern Mediterranean University
RP Angin, E (corresponding author), Eastern Mediterranean Univ, Physiotherapy & Rehabil Dept, Fac Hlth Sci, Via Mersin 10, Famagusta, North Cyprus, Turkey.
EM ender.angin@emu.edu.tr
RI Kirmizigil, Berkiye/LSJ-1463-2024; malkoç, mehtap/IAN-1219-2023; IYIGUN,
   GOZDE/W-9769-2018
OI IYIGUN, GOZDE/0000-0001-8346-9952
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NR 52
TC 11
Z9 12
U1 0
U2 24
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD MAY
PY 2018
VL 97
IS 18
AR e0485
DI 10.1097/MD.0000000000010485
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA GI3ZI
UT WOS:000434310200007
PM 29718839
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Yang, CY
   Lo, SC
   Peng, YC
AF Yang, Chiu-Yueh
   Lo, Su-Chen
   Peng, Ying-Chieh
TI Prevalence and Predictors of Metabolic Syndrome in People With
   Schizophrenia in Inpatient Rehabilitation Wards
SO BIOLOGICAL RESEARCH FOR NURSING
LA English
DT Article
DE metabolic syndrome; prevalence; predictors; schizophrenia
ID QUALITY-OF-LIFE; PHYSICAL-ACTIVITY; ATYPICAL ANTIPSYCHOTICS; DEPRESSIVE
   SYMPTOMS; SPECTRUM DISORDERS; ANXIETY; ASSOCIATIONS; OUTPATIENTS;
   MANAGEMENT; PROGRAM
AB Background: Atypical antipsychotic medications increase the risk of developing metabolic syndrome (MetS) and cardiovascular diseases in people with schizophrenia.
   Aim: To explore the prevalence of MetS and the predictors associated with the number of MetS components in people with chronic schizophrenia.
   Methods: We recruited 357 participants from 10 rehabilitation wards in northern Taiwan. The Beck Anxiety Inventory, Beck Depression Inventory-II, Health-Promoting Lifestyle Profile (HPLP), and modified Baecke physical activity questionnaire were used to evaluate the participants. MetS prevalence was calculated using the modified Adult Treatment Panel III criteria for Asians.
   Results: The prevalence of MetS in this sample was 37.8%. Multinomial logistic regression revealed that the HPLP-exercise score (odds ratio [OR] = 0.411, p = .002) and depressive symptoms (OR = 0.949, p = .040) were protective factors for 4 MetS components. The leisure physical activity level (OR = .536, p = .024) was a protective factor for three MetS components. Body mass index 24 kg/m(2) was the strongest risk factor for two MetS components (OR = 8.057, p < .001), three MetS components (OR = 11.287, p < .001), and four MetS components (OR = 15.621, p < .001). Additionally, participants' age >40 (OR = 3.638, p = .012) was a risk factor for four MetS components.
   Conclusion: In this study, the prevalence of MetS was higher than that reported for patients utilizing community-based services in Taiwan. The important risk factors for MetS were being overweight and older than 40. The protective factors for MetS were a high HPLP-exercise score and leisure-based physical activities.
C1 [Yang, Chiu-Yueh] Natl Yang Ming Univ, Dept Nursing, 155,Sec 2,Li Nong St, Taipei 112, Taiwan.
   [Lo, Su-Chen; Peng, Ying-Chieh] Minist Hlth & Welf, Dept Nursing, Bali Psychiat Ctr, New Taipei, Taiwan.
C3 National Yang Ming Chiao Tung University
RP Yang, CY (corresponding author), Natl Yang Ming Univ, Dept Nursing, 155,Sec 2,Li Nong St, Taipei 112, Taiwan.
EM cyyang3@ym.edu.tw
RI Lo, Su Chen/KIE-8099-2024; Yang, Chiu-Yueh/AEK-3524-2022
OI Yang, Chiu-Yueh/0000-0002-5907-5619
FU National Science Council, Taiwan [NSC 101-2410-H-010-012]
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: Funding
   for this study was provided, in part, by a grant from the National
   Science Council, Taiwan (NSC 101-2410-H-010-012).
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NR 52
TC 15
Z9 19
U1 0
U2 13
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1099-8004
EI 1552-4175
J9 BIOL RES NURS
JI Biol. Res. Nurs.
PD OCT
PY 2016
VL 18
IS 5
BP 558
EP 566
DI 10.1177/1099800416653184
PG 9
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA DV9MC
UT WOS:000383263600010
PM 27268516
DA 2025-06-11
ER

PT J
AU Suarez, EC
   Schramm-Sapyta, NL
   Hawkins, TV
   Erkanli, A
AF Suarez, Edward C.
   Schramm-Sapyta, Nicole L.
   Hawkins, Tracey Vann
   Erkanli, Alaattin
TI Depression inhibits the anti-inflammatory effects of leisure time
   physical activity and light to moderate alcohol consumption
SO BRAIN BEHAVIOR AND IMMUNITY
LA English
DT Article
DE Depression; Leisure time physical activity; Alcohol consumption;
   Alcohol; Ethanol; C-reactive protein; Gender differences; Interaction
ID C-REACTIVE PROTEIN; ALL-CAUSE MORTALITY; CARDIOVASCULAR-DISEASE RISK;
   CORONARY-HEART-DISEASE; INFLAMMATORY MARKERS; JOB STRAIN; METABOLIC
   SYNDROME; MAJOR DEPRESSION; AEROBIC EXERCISE; REGULAR EXERCISE
AB Light to moderate alcohol consumption and leisure time physical activity (LTPA) are independently associated with lower levels of high sensitivity C-reactive protein (CRP), a predictor of cardiometabolic risk. In contrast, depression, ranging from low mood disturbance to major depressive disorder, has been associated with elevated CRP. To test the hypothesis that depression attenuates the anti-inflammatory effects of LTPA and alcohol consumption, the current study tested the moderating effect of severity of depressive symptomatology on the relation of alcohol consumption and LTPA to CRP in 222 healthy adult men and women (18-65 years of age). Given the known effects of gender on inflammation, we also examined the effects of gender on the tested interactions. Depression was assessed using the Beck Depression Inventory. Frequency of alcohol consumption, hours of LTPA per week and other coronary risk/protective factors were assessed via self-report and structured interview. Fasting blood samples were used to measure CRP and lipids. As predicted, the interaction between LTPA and depressive symptomatology was significant (F = 5.29, p < .03) such that lower CRP was associated with the combination of decreased depressive symptomatology and increased LTPA. Among those with increased depressive symptoms, increased LTPA was not associated with higher CRP. Similarly, depression interacted with alcohol consumption in predicting CRP in men but not women (F = 5.03, p < .008) such that for men light to moderate alcohol consumption was associated with lower CRP but only among those with decreased depressive symptoms. Light to moderate alcohol consumption was not associated with lower CRP in those with increased depressive symptom severity. The pattern of the interactions between anti-inflammatory activities such as light to moderate alcohol consumption and LTPA and psychological distress as indexed by severity of depressive symptomatology suggests an important new avenue for future research. (C) 2013 Elsevier Inc. All rights reserved.
C1 [Suarez, Edward C.; Schramm-Sapyta, Nicole L.; Hawkins, Tracey Vann] Duke Univ, Med Ctr, Dept Psychiat, Durham, NC 27710 USA.
   [Erkanli, Alaattin] Duke Univ, Sch Med, Dept Biostat & Bioinformat, Durham, NC USA.
C3 Duke University; Duke University
RP Suarez, EC (corresponding author), Duke Univ, Med Ctr, POB 3328, Durham, NC 27710 USA.
EM edward.suarez@duke.edu
RI Stefanadis, Christodoulos/ABH-2232-2020; Suarez, Edward/HPE-3092-2023
OI Stefanadis, Christodoulos/0000-0001-5974-6454; Suarez,
   Edward/0000-0003-3069-5846
FU National Heart, Lung and Blood Institute (NHLBI) [HL67459]
FX This work was supported by a grant from National Heart, Lung and Blood
   Institute (NHLBI) HL67459 to ECS. The NHLBI did not contribute to study
   design.
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NR 83
TC 8
Z9 8
U1 0
U2 21
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0889-1591
EI 1090-2139
J9 BRAIN BEHAV IMMUN
JI Brain Behav. Immun.
PD AUG
PY 2013
VL 32
BP 144
EP 152
DI 10.1016/j.bbi.2013.03.009
PG 9
WC Immunology; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Immunology; Neurosciences & Neurology; Psychiatry
GA 168YG
UT WOS:000320743300017
PM 23541381
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Lambert, EA
   Lambert, GW
AF Lambert, Elisabeth A.
   Lambert, Gavin W.
TI Stress and Its Role in Sympathetic Nervous System Activation in
   Hypertension and the Metabolic Syndrome
SO CURRENT HYPERTENSION REPORTS
LA English
DT Article
DE Stress; Sympathetic nervous system; Obesity; Metabolic syndrome
ID OBESITY-RELATED HYPERTENSION; PREDICT INSULIN-RESISTANCE; PSYCHOSOCIAL
   STRESS; BLOOD-PRESSURE; RISK-FACTORS; CARDIOVASCULAR-DISEASE; VISCERAL
   OBESITY; CARDIAC RISK; US ADULTS; BODY-MASS
AB Stress in several guises is evident in individuals with hypertension and in those with the metabolic syndrome and may account, at least in part, for the extent and pattern of sympathetic nervous activation. Importantly, elevated activity of the sympathetic nervous system is related to the development of obesity-related illnesses including hypertension, insulin resistance, and renal, cardiac, and vascular impairment. Notably, evidence of subclinical organ damage is evident even in young, normotensive, overweight persons, thereby reinforcing the need to develop and implement effective early intervention.
C1 [Lambert, Elisabeth A.; Lambert, Gavin W.] Baker IDI Heart & Diabet Inst, Human Neurotransmitters Lab, Melbourne, Vic 8008, Australia.
C3 Baker Heart and Diabetes Institute
RP Lambert, EA (corresponding author), Baker IDI Heart & Diabet Inst, Human Neurotransmitters Lab, POB 6492,St Kilda Rd Cent, Melbourne, Vic 8008, Australia.
EM Elisabeth.lambert@bakeridi.edu.au
RI Lambert, Elisabeth/E-7463-2010; Lambert, Gavin/E-7384-2010
OI Lambert, Elisabeth/0000-0002-2232-9048; Lambert,
   Gavin/0000-0003-0315-645X
FU National Health and Medical Research Council of Australia (NHMRC);
   Abbot; Servier; Ardian Inc; Allergan; Scientific Intake
FX This work was supported by grants from the National Health and Medical
   Research Council of Australia (NHMRC).The investigators (or their
   laboratory) have received research funding from commercial sponsors
   including Abbot (formerly Solvay Pharmaceuticals), Servier, Ardian Inc,
   Allergan, and Scientific Intake. Dr. Gavin Lambert has received
   honoraria or travel support for presentations from Servier, Wyeth
   Pharmaceuticals, and Pfizer. No other potential conflicts of interest
   relevant to this article were reported.
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NR 49
TC 70
Z9 80
U1 3
U2 27
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1522-6417
EI 1534-3111
J9 CURR HYPERTENS REP
JI Curr. Hypertens. Rep.
PD JUN
PY 2011
VL 13
IS 3
BP 244
EP 248
DI 10.1007/s11906-011-0186-y
PG 5
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 749PK
UT WOS:000289480600011
PM 21271362
DA 2025-06-11
ER

PT J
AU Valtonen, MK
   Laaksonen, DE
   Laukkanen, JA
   Tolmunen, T
   Viinamäki, H
   Lakka, HM
   Lakka, TA
   Niskanen, L
   Kauhanen, J
AF Valtonen, Maarit K.
   Laaksonen, David E.
   Laukkanen, Jari A.
   Tolmunen, Tommi
   Viinamaki, Heimo
   Lakka, Hanna-Maaria
   Lakka, Timo A.
   Niskanen, Leo
   Kauhanen, Jussi
TI Low-grade inflammation and depressive symptoms as predictors of
   abdominal obesity
SO SCANDINAVIAN JOURNAL OF PUBLIC HEALTH
LA English
DT Article
DE Inflammation; depression; obesity; metabolic syndrome; cohort; men
ID C-REACTIVE PROTEIN; METABOLIC SYNDROME; HYPERCORTISOLEMIC DEPRESSION;
   CYTOKINES; PATHOPHYSIOLOGY; HOPELESSNESS; MORTALITY
AB Aim: Abundant evidence suggests that depression is a risk factor for cardiovascular disease and metabolic syndrome. Systemic low-grade inflammation and evolving abdominal obesity are hypothesised to be underlying mechanisms explaining the relationship. To test this hypothesis we examined the association of depressive symptoms and inflammation in developing abdominal obesity. Methods: The subjects were 726 non-diabetic men, 42-60 of age at baseline, participating in the Kuopio Ischemic Heart Disease Risk Factor Study. The follow-up data was collected 11 years after the baseline. Low-grade inflammation was defined as serum C-reactive protein >= 2 mg/l and depressive symptoms were assessed by the Human Population Laboratory Depression Scale. Incident abdominal obesity was defined as waist girth > 102 cm. Results: Men with low-grade inflammation and depressive symptoms were more likely (OR 4.28, 95% CI 1.93-12.01) to develop abdominal obesity during the 11-year follow-up than in men not having either of these conditions, adjusting for age, smoking, alcohol consumption, prevalent cardiovascular disease, physical activity and socioeconomic status. These men were also more likely (OR 3.94, 95% CI 1.38-11.26) to develop metabolic syndrome. Conclusions: The presence of systemic low-grade inflammation together with depressive symptoms seems to detect men at a particularly high risk of developing abdominal obesity over a long period of time.
C1 [Valtonen, Maarit K.] LIKES Res Ctr Sport & Hlth Sci, Jyvaskyla 40720, Finland.
   [Laaksonen, David E.] Kuopio Univ Hosp, Dept Med, Kuopio, Finland.
   [Laaksonen, David E.; Lakka, Timo A.] Univ Eastern Finland, Dept Physiol, Inst Biomed, Helsinki, Finland.
   [Laukkanen, Jari A.; Lakka, Hanna-Maaria; Kauhanen, Jussi] Univ Eastern Finland, Sch Publ Hlth & Clin Nutr, Helsinki, Finland.
   [Tolmunen, Tommi; Viinamaki, Heimo] Kuopio Univ Hosp, Dept Psychiat, Kuopio, Finland.
   [Lakka, Timo A.] Kuopio Res Inst Exercise Med, Kuopio, Finland.
   [Niskanen, Leo] Cent Finland Cent Hosp, Dept Internal Med, Helsinki, Finland.
   [Niskanen, Leo] Univ Eastern Finland, Fac Hlth Sci, Inst Clin Sci, Helsinki, Finland.
C3 Kuopio University Hospital; University of Eastern Finland; University of
   Eastern Finland Hospital; University of Eastern Finland; University of
   Eastern Finland; Kuopio University Hospital; University of Eastern
   Finland; University of Eastern Finland Hospital; Central Finland Central
   Hospital; University of Eastern Finland
RP Valtonen, MK (corresponding author), LIKES Res Ctr Sport & Hlth Sci, Viitaniementie 15A, Jyvaskyla 40720, Finland.
EM maarit.valtonen@likes.fi
RI Kauhanen, Jussi/ABC-4064-2021; Laukkanen, Jari/N-2196-2019; Laukkanen,
   Jari/I-4528-2017
OI Laukkanen, Jari/0000-0002-3738-1586; Lakka, Timo/0000-0002-9199-2871
FU Academy of Finland [118551, 41471, 1041086, 2041022]; Ministry of
   Education of Finland [167/722/96, 157/722/97, 156/722/98]; National
   Heart, Lung and Blood Institute of the USA [HL44199]; LIKES -Foundation
   for Sport and Health Sciences; National Graduate School of Clinical
   Investigation; Onni and Hilja Tuovinen Foundation; Orion Pharmos
   Foundation; Yrjo Jahnsson Foundation; Ida Montin Foundation; Juho Vaino
   Foundation
FX The KIHD study was supported by grants from the Academy of Finland
   [grants 118551, 41471, 1041086 and 2041022], the Ministry of Education
   of Finland [grants 167/722/96, 157/722/97, 156/722/98], and the National
   Heart, Lung and Blood Institute of the USA [grant HL44199]. M.V. is
   supported by LIKES -Foundation for Sport and Health Sciences, The
   National Graduate School of Clinical Investigation and by grants from
   the Onni and Hilja Tuovinen Foundation, Orion Pharmos Foundation, Yrjo
   Jahnsson Foundation, Ida Montin Foundation and Juho Vaino Foundation.
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NR 31
TC 22
Z9 23
U1 0
U2 11
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1403-4948
EI 1651-1905
J9 SCAND J PUBLIC HEALT
JI Scand. J. Public Health
PD NOV
PY 2012
VL 40
IS 7
BP 674
EP 680
DI 10.1177/1403494812461730
PG 7
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA 034OW
UT WOS:000310883800014
PM 23042459
DA 2025-06-11
ER

PT J
AU Assis, FSD
   Vasconcellos, GL
   Lopes, DJP
   de Macedo, LR
   Silva, M
AF Assis, Fernanda Souza de Oliveira
   Vasconcellos, Gabriel Lima
   Lopes, Diego Jose Pereira
   de Macedo, Leandro Roberto
   Silva, Maisa
TI Effect of Green Tea Supplementation on Inflammatory Markers among
   Patients with Metabolic Syndrome and Related Disorders: A Systematic
   Review and Meta-Analysis
SO PREVENTIVE NUTRITION AND FOOD SCIENCE
LA English
DT Review
DE green tea; inflammation; meta-analysis; metabolic syndrome; randomized
   controlled trial
ID CARDIOMETABOLIC RISK-FACTORS; RANDOMIZED CONTROLLED-TRIAL; C-REACTIVE
   PROTEIN; INSULIN-RESISTANCE; DOUBLE-BLIND; ENDOTHELIAL FUNCTION;
   OXIDATIVE STRESS; BLOOD-PRESSURE; WEIGHT-LOSS; CONSUMPTION
AB Several randomized controlled trials (RCTs) have investigated the potential benefits of green tea on the inflammatory process in metabolic syndrome (MetS). However, the results are inconclusive and inconsistent. In the present study, we performed a literature review and meta-analysis to evaluate the effect of green tea supplementation on inflammatory markers [e.g., tumor necrosis factor-a (TNF-a), C-reactive protein (CRP), and interleukin-6 (IL-6)] among patients with MetS and related disorders. We systematically searched for relevant publications up to March 2022 in the PubMed, Scopus, Web of Science, and SciELO databases. The review was registered with PROSPERO (CRD42022320345). Mean differences with 95% confidence intervals were pooled on the basis of the random effects model to compare the effects of green tea with placebo. We used meta-regression and subgroup analyses to determine the cause of heterogeneity and performed study quality assessment using the Grading of Recommendations Assessment, Development, and Evaluation method. We assessed publication bias using funnel plots and Egger's tests. Out of the total 15 RCTs that were included in this systematic review, 12 were chosen for the meta-analysis. The results revealed that green tea significantly decreased TNF-a levels but did not affect CRP and IL-6 levels. Subgroup analysis showed that green tea supplementation in studies lasting <= 8 weeks significantly increased CRP levels. Furthermore, meta-regression analysis demonstrated a significant association between increasing IL-6 concentration and treatment duration. According to our meta-analysis, green tea was shown to considerably lower circulating TNF-a levels. To confirm these findings, carefully planned trials are required.
C1 [Assis, Fernanda Souza de Oliveira; Silva, Maisa] Univ Fed Juiz de Fora, Dept Basic Life Sci, BR-35020360 Governador Valadares, Brazil.
   [Vasconcellos, Gabriel Lima; Lopes, Diego Jose Pereira] Univ Fed Juiz de Fora, Dept Med, Campus Governador Valadares, BR-35020360 Governador Valadares, Brazil.
   [de Macedo, Leandro Roberto] Univ Fed Juiz de Fora, Dept Econ, BR-35020360 Governador Valadares, Brazil.
RP Silva, M (corresponding author), Univ Fed Juiz de Fora, Dept Basic Life Sci, BR-35020360 Governador Valadares, Brazil.
EM maisa.silva@ufjf.edu.br
RI Silva, Carolina/JQV-4022-2023; Macedo, Leandro/AHE-8759-2022
OI Silva, Maisa/0000-0003-3996-159X; Vasconcellos,
   Gabriel/0009-0009-4037-0245
FU VIC/UFJF scholarships.
FX This research did receive sources of funding through VIC/UFJF
   scholarships.
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NR 60
TC 2
Z9 2
U1 0
U2 1
PU KOREAN SOC FOOD SCIENCE NUTRITION
PI BUSAN
PA 1010, 993, JUNGANG-DAERO, BUSANJIN-GU, BUSAN, 47209, SOUTH KOREA
SN 2287-1098
EI 2287-8602
J9 PREV NUTR FOOD SCI
JI Prev. Nutr. Food Sci.
PD JUN
PY 2024
VL 29
IS 2
BP 106
EP 117
DI 10.3746/pnf.2024.29.2.106
PG 12
WC Food Science & Technology; Nutrition & Dietetics
WE Emerging Sources Citation Index (ESCI)
SC Food Science & Technology; Nutrition & Dietetics
GA J0X6C
UT WOS:001334389400002
PM 38974590
DA 2025-06-11
ER

PT J
AU Li, HX
   Ye, ZT
   Zheng, GJ
   Su, ZQ
AF Li, Hongxia
   Ye, Zeting
   Zheng, Guangjuan
   Su, Zuqing
TI Polysaccharides targeting autophagy to alleviate metabolic syndrome
SO INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
LA English
DT Review
DE Metabolic syndrome; Autophagy; Polysaccharides
ID PROMOTES LIVER STEATOSIS; BETA-CELL MASS; INSULIN SENSITIVITY;
   SKELETAL-MUSCLE; ER STRESS; TRANSCRIPTION FACTORS; STIMULATES AUTOPHAGY;
   ENHANCING AUTOPHAGY; OXIDATIVE STRESS; DOWN-REGULATION
AB Metabolic syndrome is a prevalent non-communicable disease characterized by central obesity, insulin resistance, hypertension, hyperglycemia, and hyperlipidemia. Epidemiological statistics indicate that one-third of the world's population is affected by metabolic syndrome. Unfortunately, owing to complicated pathogenesis and limited pharmacological options, the growing prevalence of metabolic syndrome threatens human health worldwide. Autophagy is an intracellular degradation mechanism that involves the degradation of unfolded or aggregated proteins and damaged cellular organelles, thereby maintaining metabolic homeostasis. Increasing evidence indicates that dysfunctional autophagy is closely associated with the development of metabolic syndrome, making it an attractive therapeutic target. Furthermore, a growing number of plant-derived polysaccharides have been shown to regulate autophagy, thereby alleviating metabolic syndrome, such as Astragalus polysaccharides, Laminaria japonica polysaccharides, Ganoderma lucidum polysaccharides and Lycium barbarum polysaccharides. In this review, we summarize recent advances in the discovery of autophagy modulators of plant polysaccharides for the treatment of metabolic syndrome, with the aim of providing precursor compounds for the development of new therapeutic agents. Additionally, we look forward to seeing more diseases being treated with plant polysaccharides by regulating autophagy, as well as the discovery of more intricate mechanisms that govern autophagy.
C1 [Li, Hongxia; Ye, Zeting; Su, Zuqing] Guangzhou Univ Chinese Med, Affiliated Hosp 2, State Key Lab Tradit Chinese Med Syndrome, Guangzhou, Peoples R China.
   [Zheng, Guangjuan] Guangzhou Univ Chinese Med, State Key Lab Dampness Syndrome Chinese Med, Affiliated Hosp 2, Guangzhou, Peoples R China.
   [Li, Hongxia; Ye, Zeting; Zheng, Guangjuan; Su, Zuqing] Guangzhou Univ Chinese Med, Dept Pharmacol Tradit Chinese Med, Clin Coll 2, Guangzhou, Peoples R China.
   [Li, Hongxia; Ye, Zeting; Zheng, Guangjuan; Su, Zuqing] Guangzhou Univ Chinese Med, Clin Coll 2, Guangdong Prov Key Lab Chinese Med Prevent & Treat, Guangzhou, Peoples R China.
C3 Guangzhou University of Chinese Medicine; Guangzhou University of
   Chinese Medicine; Guangzhou University of Chinese Medicine; Guangzhou
   University of Chinese Medicine
RP Zheng, GJ; Su, ZQ (corresponding author), Guangzhou Univ Chinese Med, Dept Pharmacol Tradit Chinese Med, Clin Coll 2, Guangzhou, Peoples R China.
EM zhengguangjuan@gzucm.edu.cn; suzq@gzucm.edu.cn
RI Zheng, Guangjuan/ABB-6496-2020
FU State Key Laboratory of Traditional Chinese Medicine Syndrome; Second
   Affiliated Hospital of Guangzhou University of Chinese Medicine
   [QZ2023ZZ39]; Research Fund for Zhaoyang Talents of Guangdong Provincial
   Hospital of Chinese Medicine [ZY2022KY12]; Specific Fund of State Key
   Laboratory of Dampness Syndrome of Chinese Medicine [SZ2021ZZ20];
   Guangdong Provincial Science and Technology Innovation Strategy Special
   Fund (Guangdong-Hong Kong-Macau Joint Lab) [2020B1212030006]; Guangdong
   Provincial Key Laboratory of Chinese Medicine for Prevention and
   Treatment of Refractory Chronic Diseases [2023KT15523, YN2023MB11]
FX This work was supported by grants from the State Key Laboratory of
   Traditional Chinese Medicine Syndrome, The Second Affiliated Hospital of
   Guangzhou University of Chinese Medicine (No. QZ2023ZZ39) , the Research
   Fund for Zhaoyang Talents of Guangdong Provincial Hospital of Chinese
   Medicine (No. ZY2022KY12) , the Specific Fund of State Key Laboratory of
   Dampness Syndrome of Chinese Medicine under Grant (No. SZ2021ZZ20) , the
   2020 Guangdong Provincial Science and Technology Innovation Strategy
   Special Fund (Guangdong-Hong Kong-Macau Joint Lab) (No. 2020B1212030006)
   , the Guangdong Provincial Key Laboratory of Chinese Medicine for
   Prevention and Treatment of Refractory Chronic Diseases (No. 2023KT15523
   and YN2023MB11) .
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NR 212
TC 1
Z9 1
U1 11
U2 15
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0141-8130
EI 1879-0003
J9 INT J BIOL MACROMOL
JI Int. J. Biol. Macromol.
PD DEC
PY 2024
VL 283
AR 137393
DI 10.1016/j.ijbiomac.2024.137393
EA NOV 2024
PN 1
PG 16
WC Biochemistry & Molecular Biology; Chemistry, Applied; Polymer Science
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry; Polymer Science
GA M7M5X
UT WOS:001359339200001
PM 39521230
DA 2025-06-11
ER

PT J
AU Voltas, N
   Arija, V
   Aparicio, E
   Canals, J
AF Voltas, Nuria
   Arija, Victoria
   Aparicio, Estefania
   Canals, Josefa
TI Longitudinal study of psychopathological, anthropometric and
   sociodemographic factors related to the level of Mediterranean diet
   adherence in a community sample of Spanish adolescents
SO PUBLIC HEALTH NUTRITION
LA English
DT Article
DE Mediterranean diet; Adolescents; Psychopathology; Risk factors
ID BODY-MASS INDEX; DEPRESSIVE SYMPTOMS; METABOLIC SYNDROME; GREEK
   ADOLESCENTS; CHILDHOOD OBESITY; QUALITY INDEX; MENTAL-HEALTH; CHILDREN;
   SCREEN; PATTERN
AB Objective The Mediterranean diet (MD) pattern has important health benefits; however, it seems that Spanish school-aged children have been abandoning this healthy pattern recently. We aimed to identify psychopathological, anthropometric and sociodemographic factors that may influence the risk of low MD adherence.
   Design Longitudinal study in three phases. MD adherence was assessed using the Krece Plus food questionnaire and psychopathological symptoms using the Screen for Childhood Anxiety Related Emotional Disorders, Children's Depression Inventory, Youth's Inventory-4 and Eating Disorder Inventory-2. Anthropometric data were collected in the first and third phases.
   Settings All five representative areas in Reus, Spain.
   Subjects Adolescents (n 241).
   Results Regardless of past and current BMI, socio-economic status was a protective factor for low MD adherence (OR=0805, P=0003) and a risk factor for high BMI (OR=0718, P=0002; OR=0707, P=0001). Regardless of socio-economic status, depression was involved with risk of low adherence (OR=1069, P=0021). Girls with lower MD adherence presented significantly higher scores for eating disorders measured using the Eating Disorder Inventory-2 (low adherence, mean 189 (sd 135); high adherence, mean 89 (sd 90), P=0020) and the Youth Inventory-4 (low adherence, mean 52 (sd 43); medium adherence, mean 36 (sd 32), P=0044). They also presented higher depression symptoms (low adherence, mean 177 (sd 96); medium adherence, mean 123 (sd 72), P=001) than girls with high adherence.
   Conclusions The results highlight the influence of psychosocial factors on levels of MD adherence. These factors need to be taken into account when developing prevention and health promotion initiatives.
C1 [Voltas, Nuria; Canals, Josefa] Univ Rovira & Virgili, Dept Psychol, Res Ctr Behav Assessment CRAMC, Crta Valls S-N, E-43007 Tarragona, Spain.
   [Voltas, Nuria; Arija, Victoria; Aparicio, Estefania; Canals, Josefa] Univ Rovira & Virgili, Nutr & Mental Hlth Res Grp NUTRISAM, C St Llorenc 21, E-43201 Reus, Spain.
   [Arija, Victoria; Aparicio, Estefania] Univ Rovira & Virgili, Nutr & Publ Hlth Unit, C St Llorenc 21, E-43201 Reus, Spain.
C3 Universitat Rovira i Virgili; Universitat Rovira i Virgili; Universitat
   Rovira i Virgili
RP Canals, J (corresponding author), Univ Rovira & Virgili, Dept Psychol, Res Ctr Behav Assessment CRAMC, Crta Valls S-N, E-43007 Tarragona, Spain.; Canals, J (corresponding author), Univ Rovira & Virgili, Nutr & Mental Hlth Res Grp NUTRISAM, C St Llorenc 21, E-43201 Reus, Spain.
EM josefa.canals@urv.cat
RI Canals, Josefa/H-7551-2015; Aparicio, Estefania/AAA-8182-2020; Voltas,
   Nuria/H-8122-2015
OI Arija, Victoria/0000-0002-1758-0975; Aparicio,
   Estefania/0000-0003-0542-0015; Voltas, Nuria/0000-0001-8855-0282
FU 'Fondo de Investigaciones Sanitarias' of the Instituto de Salud Carlos
   III of the Spanish Ministry of Health, Social Services and Equality
   [PI07/0839]
FX This research was supported by a grant from the 'Fondo de
   Investigaciones Sanitarias' (PI07/0839) of the Instituto de Salud Carlos
   III of the Spanish Ministry of Health, Social Services and Equality. The
   funder had no role in the design, analysis or writing of this article.
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NR 77
TC 14
Z9 16
U1 0
U2 31
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 1368-9800
EI 1475-2727
J9 PUBLIC HEALTH NUTR
JI Public Health Nutr.
PD JUL
PY 2016
VL 19
IS 10
BP 1812
EP 1822
DI 10.1017/S1368980015003560
PG 11
WC Public, Environmental & Occupational Health; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; Nutrition & Dietetics
GA DO7PT
UT WOS:000377975200011
PM 26818065
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Jang, EH
   Jung, RM
   Lee, SM
AF Jang, Eun-Hee
   Jung, Ranmi
   Lee, Seungmin
TI Higher adherence to a Mediterranean-type diet is associated with reduced
   psychosocial stress levels in baby boomers: a cross-sectional study
SO NUTRITION RESEARCH AND PRACTICE
LA English
DT Article
DE Mediterranean diet; psychosocial stress; baby boomer; mental health;
   diet
ID METABOLIC SYNDROME; PERCEIVED STRESS; DEPRESSION; RISK; ACID;
   INFLAMMATION; METAANALYSIS; PATTERNS; MARKERS
AB BACKGROUND/OBJECTIVES: This study investigated the relationship between adherence to the Mediterranean diet among Korean baby boomers and their levels of psychosocial stress. SUBJECTS/METHODS: The study included 1,656 adults (889 men and 797 women) born between 1955 and 1963 who participated in the 2005-2006 survey of the community-based Korean Genome and Epidemiology Study (KoGES). The Mediterranean-type diet score (MTDS) was calculated from the semi-quantitative food frequency questionnaire (SQFFQ) data. The psychosocial stress levels were calculated using the psychosocial well-being indexshort form (PWI-SF). Logistic regression analyses were performed to analyze the association between the MTDS (tertiles) and the prevalence of high psychosocial stress by gender. RESULTS: The ranges of the MTDS tertile groups were T1 (20-33 points), T2 (34-37 points), and T3 (38-39 points) for men, T1 (20-33 points), T2 (34-37 points), and T3 (38-48 points) for women. In both men and women, the consumption of whole grains, potatoes, fruits, vegetables, legumes, and fish increased with higher MTDS, while the consumption of red meat and dairy products decreased (P for trend < 0.05). As MTDS score increased the intake of energy, fiber, vitamins, and minerals (P for trend < 0.05). Men in the highest MTDS tertile had a 41% lower odds ratio (OR) of high psychosocial stress compared with those in the lowest tertile (OR, 0.59; 95% confidence interval [CI], 0.38-0.91). Similarly, women in the highest tertile of the MTDS had a 39% lower OR of high psychosocial stress compared with those in the lowest tertile (OR, 0.61; 95% CI, 0.40-0.95). CONCLUSION: Promoting adherence to the Mediterranean diet among baby boomers may have a positive impact on reducing their levels of psychosocial stress.
C1 [Jang, Eun-Hee; Jung, Ranmi; Lee, Seungmin] Sungshin Womens Univ, Dept Food & Nutr, Seoul 01133, South Korea.
   [Lee, Seungmin] Sungshin Womens Univ, Dept Food & Nutr, 55 Dobong Ro,76ga Gil, Seoul 01133, South Korea.
C3 Sungshin Women's University; Sungshin Women's University
RP Lee, SM (corresponding author), Sungshin Womens Univ, Dept Food & Nutr, 55 Dobong Ro,76ga Gil, Seoul 01133, South Korea.
EM smlee@sungshin.ac.kr
FU Sungshin Women's University
FX This work was supported by the Sungshin Women's University Research
   Grant of 2021.
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NR 47
TC 0
Z9 0
U1 2
U2 2
PU KOREAN NUTRITION SOC
PI SEOUL
PA 804 KST CTR, 635-4 YEOGSAM-SONG KANGNAM-KU, SEOUL, 135-703, SOUTH KOREA
SN 1976-1457
EI 2005-6168
J9 NUTR RES PRACT
JI Nutr. Res. Pract.
PD APR
PY 2024
VL 18
IS 2
BP 257
EP 268
DI 10.4162/nrp.2024.18.2.257
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA NC2M6
UT WOS:001198183800010
PM 38584810
OA gold
DA 2025-06-11
ER

PT J
AU Miller, CT
   Fraser, SF
   Selig, SE
   Rice, T
   Grima, M
   Straznicky, NE
   Levinger, I
   Lambert, EA
   van den Hoek, DJ
   Dixon, JB
AF Miller, Clint T.
   Fraser, Steve F.
   Selig, Steve E.
   Rice, Toni
   Grima, Mariee
   Straznicky, Nora E.
   Levinger, Itamar
   Lambert, Elisabeth A.
   van den Hoek, Daniel J.
   Dixon, John B.
TI The functional and clinical outcomes of exercise training following a
   very low energy diet for severely obese women: study protocol for a
   randomised controlled trial
SO TRIALS
LA English
DT Article
DE Obesity; Exercise; Body composition; Fitness; Very low energy diet
ID TRAIT ANXIETY INVENTORY; PEAK OXYGEN-UPTAKE; QUALITY-OF-LIFE; FAT-FREE
   MASS; WEIGHT-LOSS; PHYSICAL-ACTIVITY; CALORIC RESTRICTION;
   BLOOD-PRESSURE; INSULIN SENSITIVITY; MUSCLE STRENGTH
AB Background: Clinical practice guidelines globally recommend lifestyle modification including diet and exercise training as first-line treatment for obesity. The clinical benefits of exercise training in adults with obesity is well-documented; however, there is no strong evidence for the effectiveness of exercise training for weight loss in class II and class III obesity. The purpose of the randomised controlled trial described in this protocol article is to examine the effect of exercise training, in addition to a very low energy diet (VLED), in clinically severe obese women for changes in body composition, physical function, quality of life, and markers of cardiometabolic risk.
   Methods/Design: Sixty women, aged 18-50 years with a body mass index (BMI) greater than 34.9 kg.m(2) and at least one obesity-related co-morbidity, will be recruited for this 12-month study. Participants will be randomised to either exercise plus energy restriction (n = 30), or energy restriction alone (n = 30). All participants will follow an energy-restricted individualised diet incorporating a VLED component. The exercise intervention group will also receive exercise by supervised aerobic and resistance training and a home-based exercise programme totalling 300 minutes per week. Primary outcome measures include body composition and aerobic fitness. Secondary outcome measures include: physical function, cardiometabolic risk factors, quality of life, physical activity, and mental health. All outcome measures will be conducted at baseline, 3, 6 and 12 months.
   Discussion: Previous research demonstrates various health benefits of including exercise training as part of a healthy lifestyle at all BMI ranges. Although clinical practice guidelines recommend exercise training as part of first-line treatment for overweight and obesity, there are few studies that demonstrate the effectiveness of exercise in class II and class III obesity. The study aims to determine whether the addition of exercise training to a VLED provides more favourable improvements in body composition, physical function, quality of life, and markers of cardiometabolic risk for women with clinically severe obesity, compared to VLED alone.
C1 [Miller, Clint T.; Fraser, Steve F.; Selig, Steve E.; van den Hoek, Daniel J.] Deakin Univ, Sch Exercise & Nutr Sci, 221 Burwood Highway, Burwood, Vic 3125, Australia.
   [Dixon, John B.] Baker IDI Heart & Diabet Inst, Clin Obes Res Lab, Melbourne, Vic, Australia.
   [Rice, Toni; Grima, Mariee; Straznicky, Nora E.; Lambert, Elisabeth A.] Baker IDI Heart & Diabet Inst, Human Neurotransmitters & Clin Obes Res Lab, Melbourne, Vic, Australia.
   [Levinger, Itamar] Victoria Univ, Inst Sport Exercise & Act Living, Clin Exercise Sci Res Program, Melbourne, Vic 8001, Australia.
C3 Deakin University; Baker Heart and Diabetes Institute; Baker Heart and
   Diabetes Institute; Victoria University
RP Miller, CT (corresponding author), Deakin Univ, Sch Exercise & Nutr Sci, 221 Burwood Highway, Burwood, Vic 3125, Australia.
EM c.miller@deakin.edu.au
RI Lambert, Elisabeth/E-7463-2010; Dixon, John/A-5318-2011; Miller,
   Clint/I-4370-2019; van den Hoek, Dan/AAJ-8019-2020; Fraser,
   Steve/D-2044-2012; Straznicky, Nora/E-7484-2010
OI Levinger, Itamar/0000-0001-9194-2033; Lambert,
   Elisabeth/0000-0002-2232-9048; Dixon, John/0000-0001-6399-7010; Fraser,
   Steve F/0000-0003-0202-9619; Miller, Clint/0000-0001-7743-6986; van den
   Hoek, Dan/0000-0001-8335-1620
FU Future Leader Fellowship from the National Heart Foundation of Australia
   [100040]; Nestle Health Australia
FX Nestle Health Australia has provided VLED products at cost in support of
   the study. Associate Professor IL is supported by Future Leader
   Fellowship (ID: 100040) from the National Heart Foundation of Australia.
   This study has not received any external funding at this time.
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NR 112
TC 3
Z9 3
U1 0
U2 31
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1745-6215
J9 TRIALS
JI Trials
PD MAR 8
PY 2016
VL 17
AR 125
DI 10.1186/s13063-016-1232-5
PG 12
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA DF6MX
UT WOS:000371470900002
PM 26956987
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Castro-Gerónimo, V
   García-Rodríguez, RV
   Sánchez-Medina, A
   Chamorro-Cevallos, GA
   Sánchez-González, DJ
   Méndez-Bolaina, E
AF Castro-Geronimo, Van D.
   Garcia-Rodriguez, Rosa Virginia
   Sanchez-Medina, Alberto
   Chamorro-Cevallos, German A.
   Sanchez-Gonzalez, Dolores Javier
   Mendez-Bolaina, Enrique
TI C-Phycocyanin: A Phycobiliprotein from Spirulina with Metabolic
   Syndrome and Oxidative Stress Effects
SO JOURNAL OF MEDICINAL FOOD
LA English
DT Article
DE antioxidant effects; C-Phycocyanin;
   metabolic syndrome; oxidative stress;
   Spirulina; superfood
ID SPECTROSCOPIC PROPERTIES; MULTIPLE-SCLEROSIS; PLATENSIS;
   SUPPLEMENTATION; ANTIOXIDANT; INJURY; MODEL; BETA; ENHANCEMENT; RECOVERY
AB Spirulina maxima is a cyanobacterium considered a "superfood" due to its metabolites and nutrient content. These include a complex mixture of minerals, vitamins, fatty acids, proteins, and accessory pigments. In recent years, it has positioned itself as a promising source of bioactive molecules for the treatment of several diseases, including metabolic syndrome, coronary diseases, cancer, and the improvement of health modulating oxidative stress. C-Phycocyanin (C-PC) is a photosynthetic pigment from green-blue cyanobacterium and the most abundant phycobiliprotein in the Spirulina genus with various pharmacological properties attributed due to its antioxidant capacity but has no specific cellular target. This has made it a molecule of great interest in biomedical research. This review focuses on the pharmacological effects and the benefits on metabolic syndrome and oxidative stress of C-PC.
C1 [Castro-Geronimo, Van D.; Garcia-Rodriguez, Rosa Virginia; Sanchez-Medina, Alberto] Univ Veracruzana, Inst Quim Aplicada, Lab Farmacol & Quimiometria, Xalapa, Mexico.
   [Castro-Geronimo, Van D.; Mendez-Bolaina, Enrique] Univ Veracruzana, Ctr Invest Biomed, Doctorado Ciencias Biomed, Xalapa, Mexico.
   [Chamorro-Cevallos, German A.] Inst Politecn Nacl, Lab Reprod & Fertil, Mexcio City, Mexico.
   [Sanchez-Gonzalez, Dolores Javier] Inst Politecn Nacl, Lab Toxicol Preclin, Mexcio City, Mexico.
   [Mendez-Bolaina, Enrique] Univ Veracruzana, Fac Ciencias Quim, Ciencias Proc Biol, Orizaba, Mexico.
   [Mendez-Bolaina, Enrique] Univ Veracruzana, Fac Ciencias Quim, Ciencias Proc Biol, Prolongac Oriente 6 1009,Col Rafael Alvarado, Orizaba 94340, Mexico.
   [Garcia-Rodriguez, Rosa Virginia] Univ Veracruzana, Lab Farmacol & Quimiometrıa, Inst Quım Aplicada, Ave Dr Luis Castelazo Ayala S-N,Col Ind Animas, Xalapa 91190, Mexico.
C3 Universidad Veracruzana; Universidad Veracruzana; Universidad
   Veracruzana; Universidad Veracruzana; Universidad Veracruzana
RP Méndez-Bolaina, E (corresponding author), Univ Veracruzana, Fac Ciencias Quim, Ciencias Proc Biol, Orizaba, Mexico.; Méndez-Bolaina, E (corresponding author), Univ Veracruzana, Fac Ciencias Quim, Ciencias Proc Biol, Prolongac Oriente 6 1009,Col Rafael Alvarado, Orizaba 94340, Mexico.; García-Rodríguez, RV (corresponding author), Univ Veracruzana, Lab Farmacol & Quimiometrıa, Inst Quım Aplicada, Ave Dr Luis Castelazo Ayala S-N,Col Ind Animas, Xalapa 91190, Mexico.
RI Sanchez Gonzalez, Dolores Javier/LRC-0795-2024
OI Sanchez Gonzalez, Dolores Javier/0009-0000-5329-2287
FU National Council of Science and Technology in Mexico (CONACyT) [CVU
   927607]
FX V.D.C.-G. thanks the National Council of Science and Technology in
   Mexico (CONACyT) for the doctoral scholarship (CVU 927607).
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NR 61
TC 5
Z9 5
U1 2
U2 16
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1096-620X
EI 1557-7600
J9 J MED FOOD
JI J. Med. Food
PD SEP 1
PY 2024
VL 27
IS 9
BP 807
EP 813
DI 10.1089/jmf.2022.0113
EA SEP 2023
PG 7
WC Chemistry, Medicinal; Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Food Science & Technology; Nutrition &
   Dietetics
GA G2A3E
UT WOS:001173591100001
PM 37668603
DA 2025-06-11
ER

PT J
AU Chrysohoou, C
   Kollia, N
   Tousoulis, D
AF Chrysohoou, Christina
   Kollia, Natasa
   Tousoulis, Dimitris
TI The link between depression and atherosclerosis through the pathways of
   inflammation and endothelium dysfunction
SO MATURITAS
LA English
DT Article
DE Depression; Cardiovascular disease; Mechanisms
ID CARDIOVASCULAR-DISEASE INCIDENCE; CORONARY-ARTERY-DISEASE; C-REACTIVE
   PROTEIN; MEDITERRANEAN DIET; METABOLIC SYNDROME; MAJOR DEPRESSION;
   OBESE-PATIENTS; HEART-DISEASE; ANXIETY; MARKERS
AB A large body of evidence suggests that depression increases the risk of cardiovascular morbidity and mortality. The elevated risk associated with depression is not limited to clinical major depressive disorder but also extends to sub-syndromal depressive symptoms and constructs with overlapping characteristics, such as vital exhaustion. Multiple pathophysiological pathways are involved in the relationship between depressive symptoms and atherosclerosis and its clinical manifestations and progression. These underlying mechanisms are not yet fully understood and need further clarification. This review examines inflammation and endothelium dysfunction as potential biological factors involved in the relationship between depressive symptoms and atherosclerosis. It has been reported that systemic inflammation and psychological factors interact through complex pathophysiological and behavioral mechanisms and one question that has been raised concerns whether the inflammation drives depression or vice versa, or whether the association is merely coincidental. Although further investigation is needed, including well-designed prospective studies, to address this question thoroughly, it seems that there is a feedback relationship, although the biological pathways of each direction may be distinct.
C1 [Chrysohoou, Christina; Tousoulis, Dimitris] Univ Athens, Sch Med, Cardiol Clin 1, Athens, Greece.
   [Kollia, Natasa] Harokopio Univ, Sch Hlth Sci & Educ, Dept Nutr & Dietet, Athens, Greece.
C3 Athens Medical School; National & Kapodistrian University of Athens;
   Harokopio University Athens
RP Chrysohoou, C (corresponding author), 46 Paleon Polemiston St, Glifadha 16674, Attica, Greece.
EM chrysohoou@usa.net
OI Chrysohoou, Christina/0000-0002-6340-3996
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NR 50
TC 63
Z9 67
U1 1
U2 20
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0378-5122
EI 1873-4111
J9 MATURITAS
JI Maturitas
PD MAR
PY 2018
VL 109
BP 1
EP 5
DI 10.1016/j.maturitas.2017.12.001
PG 5
WC Geriatrics & Gerontology; Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Obstetrics & Gynecology
GA FX6XC
UT WOS:000426229600002
PM 29452775
DA 2025-06-11
ER

PT J
AU Seppälä, J
   Vanhala, M
   Kautiainen, H
   Eriksson, J
   Kampman, O
   Mäntyselkä, P
   Oksa, H
   Ovaskainen, Y
   Viikki, M
   Koponen, H
AF Seppala, Jussi
   Vanhala, Mauno
   Kautiainen, Hannu
   Eriksson, Johan
   Kampman, Olli
   Mantyselka, Pekka
   Oksa, Heikki
   Ovaskainen, Yrjo
   Viikki, Merja
   Koponen, Hannu
TI Prevalence of metabolic syndrome in subjects with melancholic and
   non-melancholic depressive symptoms. A Finnish population-based study
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Antidepressive medication; Beck depression inventory; Depressive
   symptoms; Melancholic depressive symptoms; Non-melancholic depressive
   symptoms; Metabolic syndrome
ID UNHEALTHY LIFE-STYLES; MAJOR DEPRESSION; INSULIN-RESISTANCE;
   RISK-FACTOR; ANXIETY; HEALTH; NETHERLANDS; INVENTORY; FINLAND
AB Background: We aimed to evaluate the prevalence of the metabolic syndrome (MetS) and its components in subjects with predominantly melancholic or non-melancholic depressive symptoms (DS) in a population-based study evaluating the efficacy of the Finnish diabetes prevention program (FIN-D2D).
   Methods: Altogether, 4500 randomly-selected Finnish men and women aged 45-74 years were initially enrolled from the National Population Register: 2820 (63%) attended a health examination. Diagnosis of MetS was based on the criteria of the National Cholesterol Education Program (NCEP-ATPIII), and DS on the 21-item Beck Depression Inventory (BDI-21, >= 10 points). A summary score of the melancholic items in the BDI was used to divide the subjects with DS (N=432) into melancholic and a non-melancholic sub-groups.
   Results: The prevalence of MetS was higher among subjects with non-melancholic DS compared to those with melancholic DS (69% versus 55%, p 0.004). The prevalence of MetS among subjects without DS was 51%. The sex- and age-adjusted odd ratio (OR) for MetS was 2.10 (95%CI 1.62 to 2.73, p<0.001) when comparing the non-melancholic and non-depressed groups, 1.15 (95%CI 0.81 to 1.61, p=0.44) for the melancholic and non-depressed groups, and 1.84 (95%CI 1.20 to 2.80, p=0.005) for the non-melancholic and melancholic groups.
   Limitations: DS were based on a self-rating scale, and due to the cross-sectional design of our study, we cannot make inferences of causality.
   Conclusions: Compared to subjects without DS and those with melancholic DS, persons with non-melancholic DS may more frequently suffer from MetS. (C) 2011 Elsevier B.V. All rights reserved.
C1 [Seppala, Jussi] S Savo Hosp Dist, Dept Psychiat, Moisiontie 10, FIN-50520 Mikkeli, Finland.
   [Vanhala, Mauno; Kautiainen, Hannu] Cent Finland Cent Hosp, Unit Family Practice, Jyvaskyla, Finland.
   [Vanhala, Mauno] Univ Eastern Finland, Dept Family Med, Sch Publ Hlth & Clin Nutr, Kuopio, Finland.
   [Vanhala, Mauno; Mantyselka, Pekka] Kuopio Univ Hosp, Unit Family Practice, SF-70210 Kuopio, Finland.
   [Kautiainen, Hannu] ORTON, Rehabil Unit, Helsinki, Finland.
   [Eriksson, Johan] Univ Helsinki, Dept Gen Practice & Primary Hlth Care, Helsinki, Finland.
   [Eriksson, Johan] Helsinki Univ Gen Hosp, Unit Gen Practice, Helsinki, Finland.
   [Eriksson, Johan] Natl Inst Hlth & Welf, Helsinki, Finland.
   [Eriksson, Johan] Folkhalsan Res Ctr, Helsinki, Finland.
   [Eriksson, Johan] Vasa Cent Hosp, Vaasa, Finland.
   [Kampman, Olli; Viikki, Merja] Univ Tampere, Sch Med, FIN-33101 Tampere, Finland.
   [Kampman, Olli] Seinajoki Hosp Dist, Dept Psychiat, Seinajoki, Finland.
   [Mantyselka, Pekka] Univ Eastern Finland, Unit Primary Hlth Care, Kuopio, Finland.
   [Oksa, Heikki] Tampere Univ Hosp, Tampere, Finland.
   [Ovaskainen, Yrjo] Diacor, Helsinki, Finland.
   [Viikki, Merja] Tampere Mental Hlth Ctr, Tampere, Finland.
   [Koponen, Hannu] Univ Eastern Finland, Inst Clin Med, Dept Psychiat, Kuopio, Finland.
   [Koponen, Hannu] Kuopio Univ Hosp, Dept Psychiat, SF-70210 Kuopio, Finland.
C3 Central Finland Central Hospital; University of Eastern Finland;
   University of Eastern Finland; University of Eastern Finland Hospital;
   Kuopio University Hospital; University of Helsinki; Finland National
   Institute for Health & Welfare; Folkhalsan Research Center; Vaasa
   Central Hospital; Tampere University; University of Eastern Finland;
   Tampere University; Tampere University Hospital; University of Eastern
   Finland; Kuopio University Hospital; University of Eastern Finland;
   University of Eastern Finland Hospital
RP Seppälä, J (corresponding author), S Savo Hosp Dist, Dept Psychiat, Moisiontie 10, FIN-50520 Mikkeli, Finland.
EM jussi.seppala@esshp.fi; mauno.vanhala@ksshp.fi;
   hannu.kautiainen@medcare.fi; johan.eriksson@helsinki.fi;
   olli.kampman@uta.fi; pekka.mantyselka@uef.fi; heikki.oksa@pshp.fi;
   yrjo.ovaskainen@kolumbus.fi; merja.viikki@uta.fi; hannu.koponen@kuh.fi
RI Gibbs, J. Raphael/A-3984-2010; Kampman, Olli/AAW-2352-2021
OI Eriksson, Johan/0000-0002-2516-2060; Kampman, Olli/0000-0001-6891-2266
FU Pirkanmaa; Southern Ostrobothnia; North Ostrobothnia; Central Finland;
   Northern Savo; Finnish National Public Health Institute; Finnish
   Diabetes Association; Ministry of Social Affairs; Health in Finland;
   Finland's Slot Machine Association
FX FIN-D2D was supported by financing from the hospital districts of
   Pirkanmaa, Southern Ostrobothnia, North Ostrobothnia, Central Finland
   and Northern Savo, the Finnish National Public Health Institute, the
   Finnish Diabetes Association, the Ministry of Social Affairs and Health
   in Finland and Finland's Slot Machine Association. Funding for the study
   had no further role in study design; in the collection, analysis and
   interpretation of data; in the writing of the report; and in the
   decision to submit the paper for publication.
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NR 47
TC 38
Z9 41
U1 0
U2 8
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD FEB
PY 2012
VL 136
IS 3
BP 543
EP 549
DI 10.1016/j.jad.2011.10.032
PG 7
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA 915AT
UT WOS:000301996000045
PM 22119085
DA 2025-06-11
ER

PT J
AU Pulkki-Råback, L
   Elovainio, M
   Kivimäki, M
   Mattsson, N
   Raitakari, OT
   Puttonen, S
   Marniemi, J
   Viikari, JSA
   Keltikangas-Järvinen, L
AF Pulkki-Raback, Laura
   Elovainio, Marko
   Kivimaeki, Mika
   Mattsson, Noora
   Raitakari, Olli T.
   Puttonen, Sampsa
   Marniemi, Jukka
   Viikari, Jorma S. A.
   Keltikangas-Jarvinen, Liisa
TI Depressive Symptoms and the Metabolic Syndrome in Childhood and
   Adulthood: A Prospective Cohort Study
SO HEALTH PSYCHOLOGY
LA English
DT Article
DE metabolic syndrome; depressive symptoms; obesity; cardiovascular
   disease; childhood
ID CORONARY-HEART-DISEASE; C-REACTIVE PROTEIN; MIDDLE-AGED WOMEN;
   CARDIOVASCULAR RISK; INSULIN-RESISTANCE; YOUNG-ADULTS; SOCIAL SUPPORT;
   POPULATION; MORTALITY; HOSTILITY
AB Objective: To examine the reciprocal associations between depressive symptoms and clinical definitions of the metabolic syndrome in childhood and adulthood. Design: Population-based prospective cohort study of 921 participants (538 women and 383 men) in Finland. The components of the metabolic syndrome were measured in childhood (mean age 12 years) and again in adulthood (mean age 33 years). A revised version of the Beck Depression Inventory was used to assess depressive symptoms at the mean ages of 24 and 33. Main Outcome Measures: Metabolic syndrome defined by the National Cholesterol Education Program Adult Treatment Panel III (NCEP), the European Group for the Study of Insulin Resistance, and the International Diabetes Federation criteria. Results: to women, depressive symptoms were associated with increased risk of the metabolic syndrome in adulthood (odds ratio for NCEP metabolic syndrome per 1 SD increase in depressive symptoms 1.40, 95% confidence interval 1.05-1.85). The metabolic syndrome in childhood, in turn, predicted higher levels of depressive symptoms in adulthood (p = .03). In men, no associations were found between depressive symptoms and the clinical definitions of the metabolic syndrome. Conclusion: The process linking depressive symptoms with the metabolic syndrome may go into both directions and may begin early in life.
C1 [Pulkki-Raback, Laura; Elovainio, Marko] Univ Helsinki, Dept Psychol, FIN-00014 Helsinki, Finland.
   [Kivimaeki, Mika] UCL, Dept Epidemiol & Publ Hlth, London WC1E 6BT, England.
   [Mattsson, Noora] Univ Turku, Res Ctr Appl & Prevent Cardiovasc Med, SF-20500 Turku, Finland.
   [Raitakari, Olli T.] Univ Turku, Dept Clin Physiol, SF-20500 Turku, Finland.
   [Viikari, Jorma S. A.] Univ Turku, Dept Med, SF-20500 Turku, Finland.
   [Keltikangas-Jarvinen, Liisa] Univ Helsinki, Dept Psychol, FIN-00014 Helsinki, Finland.
C3 University of Helsinki; University of London; University College London;
   University of Turku; University of Turku; University of Turku;
   University of Helsinki
RP Pulkki-Råback, L (corresponding author), Univ Helsinki, Dept Psychol, POB 9 Siltavuorenpenger 20D, FIN-00014 Helsinki, Finland.
EM laura.pulkki-raback@helsinki.fi
RI Raitakari, Olli/AAQ-7389-2021; Kivimaki, Mika/B-3607-2012
OI Puttonen, Sampsa/0000-0002-7796-6941; Kivimaki, Mika/0000-0002-4699-5627
FU Academy of Finland [123621, 209514, 209518, 111056, 77841, 210283,
   117604]; Research Funds of the University of Helsinki [2106012]; Social
   insurance institution of Finland; Finnish Foundation of Cardiovascular
   Research; Yrjo Jahnsson Foundation; Academy of Finland (AKA) [209518]
   Funding Source: Academy of Finland (AKA)
FX This study was financially supported by the Academy of Finland (project
   No. 123621 [L.P.-R.], project numbers 209514, 209518, and 111056
   [L.K.-J.], project numbers 77841 and 210283 [O.T.R], project no 117604
   [M.K.], Research Funds of the University of Helsinki (project No.
   2106012 [L.P.-R.], the Social insurance institution of Finland, the
   Finnish Foundation of Cardiovascular Research, and the Yrjo Jahnsson
   Foundation.
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NR 45
TC 87
Z9 94
U1 0
U2 12
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 0278-6133
EI 1930-7810
J9 HEALTH PSYCHOL
JI Health Psychol.
PD JAN
PY 2009
VL 28
IS 1
BP 108
EP 116
DI 10.1037/a0012646
PG 9
WC Psychology, Clinical; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology
GA 394EA
UT WOS:000262427200013
PM 19210024
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Santos-Ledo, A
   de Luxán-Delgado, B
   Caballero, B
   Potes, Y
   Rodríguez-González, S
   Boga, JA
   Coto-Montes, A
   García-Macia, M
AF Santos-Ledo, Adrian
   Luxan-Delgado, Beatriz de
   Caballero, Beatriz
   Potes, Yaiza
   Rodriguez-Gonzalez, Susana
   Boga, Jose Antonio
   Coto-Montes, Ana
   Garcia-Macia, Marina
TI Melatonin Ameliorates Autophagy Impairment in a Metabolic Syndrome Model
SO ANTIOXIDANTS
LA English
DT Article
DE melatonin; metabolic syndrome; autophagy; lipophagy; Harderian gland
ID HAMSTER HARDERIAN-GLAND; SEXUAL DIFFERENCES; OXIDATIVE STRESS;
   ESTROUS-CYCLE; LIPID PROFILE; FRUCTOSE DIET; CHOLESTEROL; IMPROVES;
   GROWTH; ANTIOXIDANT
AB Metabolic syndrome is a global health problem in adults and its prevalence among children and adolescents is rising. It is strongly linked to a lifestyle with high-caloric food, which causes obesity and lipid metabolism anomalies. Molecular damage due to excessive oxidative stress plays a major role during the development of metabolic syndrome complications. Among the different hormones, melatonin presents strong antioxidant properties, and it is used to treat metabolic diseases. However, there is not a consensus about its use as a metabolic syndrome treatment. The aim of this study was to identify melatonin effects in a metabolic syndrome model. Golden hamsters were fed with 60% fructose-enriched food to induce metabolic syndrome and were compared to hamsters fed with regular chow diet. Both groups were also treated with melatonin. Fructose-fed hamsters showed altered blood lipid levels (increased cholesterol and LDL) and phenotypes restored with the melatonin treatment. The Harderian gland (HG), which is an ideal model to study autophagy modulation through oxidative stress, was the organ that was most affected by a fructose diet. Redox balance was altered in fructose-fed HG, inducing autophagic activation. However, since LC3-II was not increased, the impairment must be in the last steps of autophagy. Lipophagy HG markers were also disturbed, contributing to the dyslipidemia. Melatonin treatment improved possible oxidative homeostasis through autophagic induction. All these results point to melatonin as a possible treatment of the metabolic syndrome.
C1 [Santos-Ledo, Adrian] Univ Salamanca, Inst Biomed Res Salamanca IBSAL, Inst Neurosci Castilla & Leon INCYL, Cell Biol & Pathol, Salamanca 37007, Spain.
   [Luxan-Delgado, Beatriz de] Queen Mary Univ London, Barts Canc Inst, Ctr Tumour Biol, John Vane Sci Ctr, Charterhouse Sq, London EC1M 6BQ, England.
   [Caballero, Beatriz; Potes, Yaiza; Rodriguez-Gonzalez, Susana; Coto-Montes, Ana] Univ Oviedo, Fac Med, Area Biol Celular, Dept Morfol & Biol Celular, Julian Claveria S-N, Oviedo 33006, Spain.
   [Caballero, Beatriz; Potes, Yaiza; Rodriguez-Gonzalez, Susana; Coto-Montes, Ana] Inst Invest Sanitaria Principado Asturias ISPA, Av Hosp Univ S-N, Oviedo 33011, Spain.
   [Boga, Jose Antonio] Hosp Univ Cent Asturias, Serv Microbiol, Celestino Villamil S-N, Oviedo 33006, Spain.
   [Garcia-Macia, Marina] Univ Hosp Salamanca, Inst Biomed Res Salamanca, Salamanca 37007, Spain.
   [Garcia-Macia, Marina] Univ Salamanca, CSIC, Inst Funct Biol & Genom, Salamanca 37007, Spain.
   [Garcia-Macia, Marina] Inst Salud Carlos III, Ctr Invest Biomed Red Fragilidad & Envejecimiento, Madrid 28029, Spain.
C3 University of Salamanca; University of London; Queen Mary University
   London; University of Oviedo; Instituto de Investigacion Sanitaria del
   Principado de Asturias (ISPA); Central University Hospital Asturias;
   Consejo Superior de Investigaciones Cientificas (CSIC); University of
   Salamanca; Instituto de Salud Carlos III; CIBER - Centro de
   Investigacion Biomedica en Red; CIBERFES
RP Coto-Montes, A (corresponding author), Univ Oviedo, Fac Med, Area Biol Celular, Dept Morfol & Biol Celular, Julian Claveria S-N, Oviedo 33006, Spain.; Coto-Montes, A (corresponding author), Inst Invest Sanitaria Principado Asturias ISPA, Av Hosp Univ S-N, Oviedo 33011, Spain.; García-Macia, M (corresponding author), Univ Hosp Salamanca, Inst Biomed Res Salamanca, Salamanca 37007, Spain.; García-Macia, M (corresponding author), Univ Salamanca, CSIC, Inst Funct Biol & Genom, Salamanca 37007, Spain.; García-Macia, M (corresponding author), Inst Salud Carlos III, Ctr Invest Biomed Red Fragilidad & Envejecimiento, Madrid 28029, Spain.
EM santosledo@usal.es; b.luxandelgado@gmail.com;
   caballerobeatriz@uniovi.es; potesyaiza@uniovi.es; gusatan69@gmail.com;
   joseantonio.boga@sespa.es; acoto@uniovi.es; marinagarciamacia@usal.es
RI Boga, Jose/ABA-2719-2021; Santos, Adrian/HLX-7021-2023; Garcia Macia,
   Marina/AAY-4728-2021; Caballero García, Beatriz/AAC-2636-2020; Potes,
   Yaiza/AAU-2188-2021; COTO-MONTES, ANA/D-2544-2016; Garcia-Macia,
   Marina/G-6622-2015
OI Luxan-Delgado, Beatriz/0000-0003-4507-716X; Santos-Ledo,
   Adrian/0000-0002-6814-0718; COTO-MONTES, ANA/0000-0002-6609-6258; Potes,
   Yaiza/0000-0002-4687-6230; Garcia-Macia, Marina/0000-0002-3908-9060
FU Instituto de Salud Carlos III (ISCIII), Ministerio de Ciencia, and
   Innovacion y Universidades, Spain [FISS-18-PI17/02009]; Newcastle
   University, United Kingdom [C0120R3166, C0245R4032, BH182173]; Instituto
   de Salud Carlos III (ISCIII), Ministerio de Ciencia, and Innovacion y
   Universidades; University of Oviedo, Spain
FX This work was supported by Instituto de Salud Carlos III (ISCIII),
   Ministerio de Ciencia, and Innovacion y Universidades, Spain
   (FISS-18-PI17/02009); and Newcastle University, United Kingdom
   (C0120R3166, C0245R4032, and BH182173). M.G.-M. has a postdoctoral
   fellowship from the Instituto de Salud Carlos III (ISCIII), Ministerio
   de Ciencia, and Innovacion y Universidades. Financial support from the
   University of Oviedo, Spain, is also acknowledged.
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NR 41
TC 18
Z9 18
U1 0
U2 10
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD MAY
PY 2021
VL 10
IS 5
AR 796
DI 10.3390/antiox10050796
PG 11
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA SG3UZ
UT WOS:000653368100001
PM 34069820
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Fitzgerald, PJ
AF Fitzgerald, Paul J.
TI Elevated norepinephrine may be an etiological factor in a wide range of
   diseases: Age-related macular degeneration, systemic lupus
   erythematosus, atrial fibrillation, metabolic syndrome
SO MEDICAL HYPOTHESES
LA English
DT Article
ID BODY-MASS INDEX; CARDIOVASCULAR RISK-FACTORS; CORONARY-HEART-DISEASE;
   BLUE-MOUNTAINS-EYE; RHEUMATOID-ARTHRITIS; BIPOLAR DISORDER;
   ALZHEIMERS-DISEASE; HEALTHY CONTROLS; NEUROPEPTIDE-Y; PREVALENCE
AB The neurotransmitter norepinephrine (NE) participates in a broad range of physiological functions, both in the brain and in the periphery, where it is a principal output molecule of the sympathetic nervous system. NE receptors are present in nearly all, if not all, organs of the body, which may allow this molecule to play a role in a variety of disease processes. This paper examines the hypothesis elevated NE signaling, through genetics and/or environmental factors, is an etiological factor in a variety of diseases outside of the brain, including age-related macular degeneration, systemic lupus erythematosus, atrial fibrillation, and metabolic syndrome. Lines of evidence presented to assess the hypothesis include: (1) studies of noradrenergic drugs modulating the four diseases; (2) association of these diseases with bipolar disorder, hypertension, and obesity, where the latter three conditions may involve elevated NE signaling; and (3) association with psychological stress, since NE is released in response to stress. Many of the studies cited tend to support the hypothesis, or are at least consistent with it. If the hypothesis is correct, perhaps a large number of individuals would benefit from chronically taking drugs that systemically diminish noradrenergic signaling, thereby helping prevent or treat a wide variety of diseases. (C) 2013 Elsevier Ltd. All rights reserved.
C1 Johns Hopkins Univ, Solomon H Snyder Dept Neurosci, Zanvyl Krieger Mind Brain Inst, Baltimore, MD 21218 USA.
C3 Johns Hopkins University
RP Fitzgerald, PJ (corresponding author), Johns Hopkins Univ, Solomon H Snyder Dept Neurosci, Zanvyl Krieger Mind Brain Inst, 338 Krieger Hall,3400 N Charles St, Baltimore, MD 21218 USA.
EM pfitz@mbi.mb.jhu.edu
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NR 81
TC 12
Z9 14
U1 0
U2 8
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0306-9877
EI 1532-2777
J9 MED HYPOTHESES
JI Med. Hypotheses
PD MAY
PY 2013
VL 80
IS 5
BP 558
EP 563
DI 10.1016/j.mehy.2013.01.018
PG 6
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 131LK
UT WOS:000317995000011
PM 23410497
DA 2025-06-11
ER

PT J
AU Mahmoud, MA
   Ghareeb, DA
   Sahyoun, HA
   Elshehawy, AA
   Elsayed, MM
AF Mahmoud, Mohammad Ahmad
   Ghareeb, Doaa Ahmad
   Sahyoun, Heba Abdelghany
   Elshehawy, Ashraf Abdelhamed
   Elsayed, Mohammad Mohammad
TI In Vivo Interrelationship between Insulin Resistance and
   Interferon Gamma Production: Protective and Therapeutic Effect of
   Berberine
SO EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Article
ID DENSITY-LIPOPROTEIN CHOLESTEROL; TUMOR-NECROSIS-FACTOR; METABOLIC
   SYNDROME; OXIDATIVE STRESS; PROTEIN-KINASE; VULGARIS; OBESITY;
   INTERLEUKIN-6; GLUTATHIONE; GLUCOSE
AB This research was conducted to investigate if there is a relation between insulin resistance incidence and inhibition of interferon gamma production or not. Firstly, insulin resistance was induced by high fat diet (HFD) intake for 6 weeks. Secondly, berberine was used as protective/curative compound for insulin resistance. Results revealed that feeding rats HFD for 6 weeks developed features of insulin resistance (IR) syndrome. These features presented in increased body weight, hyperglycemia, hyperinsulinemia, hypercholesterolemia (with increased LDL-cholesterol and decreasedHDL-cholesterol), and hypertriglyceridemia. Level of antioxidant enzymes in HFD group was higher than in normal one. Also there was an increasing in level of proinflammatory cytokines as interleukin-(IL-) 6 and IL-12 in HFD group. Feeding rats HFD for 6 weeks also decreased level of interferon gamma (IFN-gamma). The decreased level of IFN-gamma has been shown to predict infection with infectious diseases especially viral infection. Treatment and protection with berberine 50 mg/kg/day for 2 weeks were found to be effective against the features of insulin resistance syndrome, improved levels of insulin resistance parameters, lipid profile, antioxidant enzymes, proinflammatory cytokines, and IFN-gamma.
C1 [Mahmoud, Mohammad Ahmad; Sahyoun, Heba Abdelghany; Elshehawy, Ashraf Abdelhamed] Kafrelsheikh Univ, Dept Chem, Fac Sci, Kafr Al Sheikh, Egypt.
   [Ghareeb, Doaa Ahmad; Elsayed, Mohammad Mohammad] Univ Alexandria, Dept Biochem, Fac Sci, Alexandria, Egypt.
C3 Egyptian Knowledge Bank (EKB); Kafrelsheikh University; Egyptian
   Knowledge Bank (EKB); Alexandria University
RP Mahmoud, MA (corresponding author), Kafrelsheikh Univ, Dept Chem, Fac Sci, Kafr Al Sheikh, Egypt.
EM sci_mohammadsaleh@sci.kfs.edu.eg
RI Mahmoud, Mohammad/AAX-9146-2020; Ghareeb, Doaa/R-6914-2016; Sahyon,
   Heba/ADX-7029-2022
OI Ghareeb, Doaa/0000-0003-3327-4377; Sahyon, Heba/0000-0002-4794-3802
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NR 55
TC 14
Z9 15
U1 0
U2 1
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1741-427X
EI 1741-4288
J9 EVID-BASED COMPL ALT
JI Evid.-based Complement Altern. Med.
PY 2016
VL 2016
AR 2039897
DI 10.1155/2016/2039897
PG 7
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA DV1RN
UT WOS:000382698700001
PM 27642351
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Belhadj, S
   Dal, S
   Khaskhoussi, F
   Maillard-Pedracini, E
   Hentati, O
   Sigrist, S
AF Belhadj, Sahla
   Dal, Stephanie
   Khaskhoussi, Fakhreddine
   Maillard-Pedracini, Elisa
   Hentati, Olfa
   Sigrist, Severine
TI Anorexic and metabolic effect of jojoba: potential treatment against
   metabolic syndrome and hepatic complications
SO NUTRITION & METABOLISM
LA English
DT Article
DE Hight fat Hight fat diet; Metabolic syndrome; Oxidative stress; Jojoba
ID INSULIN-RESISTANCE; OXIDATIVE STRESS; KIDNEY-DISEASE; FRUCTOSE;
   SIMMONDSIN; HEALTH; MEAL; INFLAMMATION
AB Background Evaluation of the action of various traditional plants to treat metabolic syndrome are strongly studied. In our study, we investigated the effect of the Tunisian jojoba seed on a metabolic syndrome induced in rat by the High Fat diet and High Fructose (HFHF) and its renal and hepatic complications. Methods The rats were fed with HFHF or Normal Diet (ND) for a period of 8 weeks. After that, a switch from HFHF to ND or Normal Diet Jojoba (NDJ),(jojoba diet approach) or High Fat and High Fructose and Jojoba diet (HFHFJ) (nutraceutical approach) has been done. Metabolic disorder was evaluated by measuring the fasting body weight, glycemia and C-peptide and leptin. Oxidative stress parameters like ThioBarbituric Acid Reactive Substances (TBARS) and Total Antioxidant Capacity (TAOC) were analyzed in the plasma and renal and hepatic function were determined by the measure of creatinine and alanine transferase (ALT) respectively. Histological analysis was performed on the liver, kidney and pancreas. Results HFHF diet exhibited characteristics of metabolic syndrome presented by insulin resistance, hyperinsulinemia, hyperleptinemia, fat mass with hepatic steatosis and renal disorder. HFHF diet was associated with oxidative stress (OS) presented by an increase in TBARS and a decrease in TAOC. Adding jojoba seeds to HFHF rat group diet induced a decrease in body weight, fat mass (58 and 41%), insulin resistance (59 and 56%), oxidative stress (60 and 41%), liver steatosis (from a score = 3 to a score = 0) and renal complications (25 and 42%). This effect was emphasized with diet approach. Conclusion The results demonstrated the beneficial effect of jojoba against metabolic syndrome and oxidative stress, suggesting that jojoba could be used in the prevention and treatment of metabolic syndrome.
C1 [Belhadj, Sahla; Dal, Stephanie; Maillard-Pedracini, Elisa; Sigrist, Severine] Univ Strasbourg, UMR DIATHEC, FMTS, EA 7294, Strasbourg, France.
   [Khaskhoussi, Fakhreddine] AGRO CRC, Al Amine Al Abbassi St, Tunis 1002, Tunisia.
   [Hentati, Olfa] Univ Sfax, Inst Super Biotechnol Sfax, Route Soukra,Km 4,BP 1175, Sfax 3038, Tunisia.
   [Hentati, Olfa] Univ Sfax, Lab Genie Environm & Ecotechnol, Ecole Natl Ingenieurs Sfax, LGEET LR16ES19 ENIS, Route Soukra,Km 4,BP 1173, Sfax 3038, Tunisia.
C3 Universites de Strasbourg Etablissements Associes; Universite de
   Strasbourg; Universite de Sfax; Universite de Sfax; Ecole Nationale
   dIngenieurs de Sfax (ENIS)
RP Sigrist, S (corresponding author), Univ Strasbourg, UMR DIATHEC, FMTS, EA 7294, Strasbourg, France.
EM s.sigrist@defymed.com
RI Sahla, Belhadj/AAP-3056-2020; Hentati, Olfa/HMW-1604-2023
OI Sahla, belhadj/0000-0002-7146-8853
FU Campus France; Ministry of Higher Education and Scientific Research and
   Technology of Tunisia; French foundation "vaincre le diabete; ASDIA
   (Assistance Service DIAbete)
FX This work has been supported by Campus France, the Ministry of Higher
   Education and Scientific Research and Technology of Tunisia, the French
   foundation "vaincre le diabete," and ASDIA (Assistance Service DIAbete).
   We would like to thank Editage (www.editage.com) for English language
   editing. The authors wish to thank Fakhreddine Khaskhoussi, engineer and
   expert in agronomy specializing in the defense of the culture of
   AGRO-CRC, for the identification of jojoba.
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NR 47
TC 11
Z9 12
U1 1
U2 8
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1743-7075
J9 NUTR METAB
JI Nutr. Metab.
PD MAR 30
PY 2020
VL 17
IS 1
AR 24
DI 10.1186/s12986-020-00441-3
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA KZ0RW
UT WOS:000522980300003
PM 32256672
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Ferreira-Santos, P
   Aparicio, R
   Carrón, R
   Montero, MJ
   Sevilla, MA
AF Ferreira-Santos, Pedro
   Aparicio, Ruben
   Carron, Rosalia
   Jose Montero, M.
   Angeles Sevilla, M.
TI Lycopene-supplemented diet ameliorates metabolic syndrome induced by
   fructose in rats
SO JOURNAL OF FUNCTIONAL FOODS
LA English
DT Article
DE Lycopene; Fructose metabolic syndrome; Hypertension; Dyslipidemia;
   Endotelial-dysfunction; Oxidative-stress
ID MEDITERRANEAN DIET; OXIDATIVE STRESS; ADIPOSE-TISSUE; CARDIOVASCULAR
   RISK; LIPID PROFILE; HYPERTENSION; METAANALYSIS; PREVENTS; ANTIOXIDANTS;
   INFLAMMATION
AB This study aimed to evaluate the effect of a lycopenesupplemented diet on a model of metabolic syndrome induced by fructose. Male Wistar rats receiving a normal diet plus tap water with 20% fructose (F) were used; half were treated simultaneously with 0.01% lycopene (FL). Rats receiving a normal diet were also divided into two groups, a control group untreated (C) and another with lycopene treatment (L). Fructose intake progressively increased the blood pressure, caused cardiac hypertrophy and endothelial dysfunction, as well as metabolic changes. Lycopene treatment significantly attenuated the development of hypertension and endothelial dysfunction and prevented cardiac hypertrophy, but had no effect in rats fed with standard diet. Others manifestations of metabolic syndrome like insulin resistance, dyslipidemia, liver enlargement, accumulation of intraperitoneal fat or oxidative stress were also improved by lycopene. In conclusion, our results suggest that lycopene significantly attenuates pathophysiological condition of metabolic syndrome caused by fructose consumption.
C1 [Ferreira-Santos, Pedro; Aparicio, Ruben; Carron, Rosalia; Jose Montero, M.; Angeles Sevilla, M.] Univ Salamanca, Fac Pharm, Dept Physiol & Pharmacol, Salamanca 37007, Spain.
   Hosp Virgen de la Vega, Biomed Res Inst Salamanca IBSAL, Salamanca 37007, Spain.
C3 University of Salamanca
RP Sevilla, MA (corresponding author), Univ Salamanca, Fac Pharm, Dept Physiol & Pharmacol, Salamanca 37007, Spain.
EM masevilla@usal.es
RI Montero, María/C-3084-2018; Sevilla, M/J-8146-2017; Ferreira Santos,
   Pedro Miguel/ADW-3458-2022
OI Ferreira Santos, Pedro Miguel/0000-0002-9427-4605
FU Ministry of Health of the Junta de Castilla y Leon (SACYL)
   [BIO/SA86/13]; University of Salamanca (Spain)
FX This work was supported by Ministry of Health of the Junta de Castilla y
   Leon (project BIO/SA86/13, SACYL) and University of Salamanca (Spain)
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NR 63
TC 13
Z9 14
U1 1
U2 14
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1756-4646
EI 2214-9414
J9 J FUNCT FOODS
JI J. Funct. Food.
PD OCT
PY 2020
VL 73
AR 104098
DI 10.1016/j.jff.2020.104098
PG 9
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA OC9UN
UT WOS:000579501700029
OA gold
DA 2025-06-11
ER

PT J
AU Yang, M
   Li, CR
   Sun, L
AF Yang, Ming
   Li, Chenrui
   Sun, Lin
TI Mitochondria-Associated Membranes (MAMs): A Novel Therapeutic Target for
   Treating Metabolic Syndrome
SO CURRENT MEDICINAL CHEMISTRY
LA English
DT Review
DE Mitochondria; endoplasmic reticulum (ER); mitochondria-associated
   membrane (MAM); metabolic syndrome; diabetes; insulin resistance
ID ENDOPLASMIC-RETICULUM STRESS; PROTEIN-KINASE-II; INSULIN-RESISTANCE; ER
   STRESS; MITOFUSIN 2; NUTRIENT AVAILABILITY; LIPID-METABOLISM;
   SKELETAL-MUSCLE; BETA-OXIDATION; GLUCOSE-UPTAKE
AB Mitochondria-associated Endoplasmic Reticulum (ER) Membranes (MAMs) are the cellular structures that connect the ER and mitochondria and mediate communication between these two organelles. MAMs have been demonstrated to be involved in calcium signaling, lipid transfer, mitochondrial dynamic change, mitophagy, and the ER stress response. In addition, MAMs are critical for metabolic regulation, and their dysfunction has been reported to be associated with metabolic syndrome, including the downregulation of insulin signaling and the accelerated progression of hyperlipidemia, obesity, and hypertension. This review covers the roles of MAMs in regulating insulin sensitivity and the molecular mechanism underlying MAM-regulated cellular metabolism and reveals the potential of MAMs as a therapeutic target in treating metabolic syndrome.
C1 [Yang, Ming; Li, Chenrui; Sun, Lin] Cent South Univ, Xiangya Hosp 2, Dept Nephrol, Hunan Key Lab Kidney Dis & Blood Purificat, 139 Renmin Middle Rd, Changsha 410011, Hunan, Peoples R China.
C3 Central South University
RP Sun, L (corresponding author), Cent South Univ, Xiangya Hosp 2, Dept Nephrol, Hunan Key Lab Kidney Dis & Blood Purificat, 139 Renmin Middle Rd, Changsha 410011, Hunan, Peoples R China.
EM sunlin@csu.edu.cn
RI Yang, Ming/KXR-7707-2024
OI Li, Chenrui/0000-0001-8997-6293
FU National Key R&D Program of China [2018YFC1314002]; National Natural
   Science Foundation of China [81730018]
FX This work has been supported by the National Key R&D Program of China
   (2018YFC1314002) and the National Natural Science Foundation of China
   (81730018).
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NR 142
TC 26
Z9 26
U1 13
U2 75
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 0929-8673
EI 1875-533X
J9 CURR MED CHEM
JI Curr. Med. Chem.
PY 2021
VL 28
IS 7
BP 1347
EP 1362
DI 10.2174/0929867327666200212100644
PG 16
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Pharmacology &
   Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
GA RN2LA
UT WOS:000640182300005
PM 32048952
DA 2025-06-11
ER

PT J
AU Matwiejuk, M
   Mysliwiec, H
   Chabowski, A
   Flisiak, I
AF Matwiejuk, Mateusz
   Mysliwiec, Hanna
   Chabowski, Adrian
   Flisiak, Iwona
TI An Overview of Growth Factors as the Potential Link between Psoriasis
   and Metabolic Syndrome
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Review
DE bFGF; HGF; NGF b; SCF; PDGF-BB; M-CSF; skin; skin diseases; psoriasis;
   metabolic syndrome
ID COLONY-STIMULATING FACTOR; STEM-CELL FACTOR; BODY-MASS INDEX;
   FACTOR-ALPHA INHIBITORS; FACTOR M-CSF; PDGF-BB; PLASMA-LEVELS; DERMAL
   FIBROBLASTS; FACTOR RECEPTOR; ADIPOSE-TISSUE
AB Psoriasis is a chronic, complex, and immunologically mediated systemic disease that not only affects the skin, but also the joints and nails. It may coexist with various other disorders, such as depression, psoriatic arthritis, cardiovascular diseases, diabetes mellitus, and metabolic syndrome. In particular, the potential link between psoriasis and metabolic syndrome is an issue worthy of attention. The dysregulation of growth factors could potentially contribute to the disturbances of keratinocyte proliferation, inflammation, and itch severity. However, the pathophysiology of psoriasis and its comorbidities, such as metabolic syndrome, remains incompletely elucidated. Growth factors and their abnormal metabolism may be a potential link connecting these conditions. Overall, the objective of this review is to analyze the role of growth factor disturbances in both psoriasis and metabolic syndrome.
C1 [Matwiejuk, Mateusz; Mysliwiec, Hanna; Flisiak, Iwona] Med Univ Bialystok, Dept Dermatol & Venereol, PL-15089 Bialystok, Poland.
   [Chabowski, Adrian] Med Univ Bialystok, Dept Physiol, PL-15089 Bialystok, Poland.
C3 Medical University of Bialystok; Medical University of Bialystok
RP Matwiejuk, M (corresponding author), Med Univ Bialystok, Dept Dermatol & Venereol, PL-15089 Bialystok, Poland.
EM mateusz.matwiejuk@sd.umb.edu.pl
RI Matwiejuk, Mateusz/KDO-6621-2024; Myśliwiec, Hanna/S-6326-2018;
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OI Matwiejuk, Mateusz/0000-0002-2873-4001; Chabowski,
   Adrian/0000-0002-7407-8156; Flisiak, Iwona/0000-0002-5923-910X
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NR 143
TC 5
Z9 5
U1 2
U2 6
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD JAN
PY 2024
VL 13
IS 1
AR 109
DI 10.3390/jcm13010109
PG 40
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA ER5Y7
UT WOS:001140676000001
PM 38202116
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Frisard, MI
   Rood, JC
   Fang, X
   Su, J
   Welsh, DA
   Jazwinski, SM
   Ravussin, E
AF Frisard, Madlyn I.
   Rood, Jennifer C.
   Fang, Xiaobing
   Su, Joseph
   Welsh, David A.
   Jazwinski, S. Michal
   Ravussin, Eric
TI Metabolic syndrome and risk factors for cardiovascular disease: are
   nonagenarians protected?
SO AGE
LA English
DT Article
DE Aging; Cardiovascular disease; Inflammation; Metabolic syndrome;
   Oxidative stress
ID C-REACTIVE PROTEIN; MYOCARDIAL-INFARCTION; HEALTHY CENTENARIANS;
   OXIDATIVE DAMAGE; PLASMA; CHOLESTEROL; ASSOCIATION; PHENOTYPE;
   STATEMENT; EVENTS
AB This study assessed cardiovascular disease risk factors in three groups of human subjects aged 20-34 [young, 20 male (M)/33 female (F)], 60-74 (aged, 29M/29F), and > 90 years (nonagenarian, 47M/50F). Components of the metabolic syndrome, cardiovascular disease, and markers of inflammation and oxidative stress were assessed. Nonagenarians weighed less than the two other groups (P < 0.001); however, there was no difference in percent fat among the three groups. Aged individuals had the highest prevalence of the metabolic syndrome (P < 0.001) according to the Adult Treatment Panel III classification. Both fibrinogen and homocysteine concentrations were significantly higher in the nonagenarians compared to younger groups. However, there were no significant differences between groups in fasting insulin, high sensitive C-reactive protein, and plasminogen activator inhibitor 1 concentrations. There were also no relationships between inflammation/ oxidative stress and the metabolic syndrome or cardiovascular disease although nonagenarians appear to be protected from oxidative damage to DNA.
C1 [Rood, Jennifer C.; Fang, Xiaobing; Ravussin, Eric] Pennington Biomed Res Ctr, Hlth & Human Performance Enhancement Div, Baton Rouge, LA 70808 USA.
   [Frisard, Madlyn I.] Virginia Polytech Inst & State Univ, Blacksburg, VA 24061 USA.
   [Su, Joseph; Welsh, David A.] Louisiana State Univ, Hlth Sci Ctr, New Orleans, LA USA.
   [Jazwinski, S. Michal] Tulane Univ, New Orleans, LA 70118 USA.
C3 Louisiana State University System; Louisiana State University;
   Pennington Biomedical Research Center; Virginia Polytechnic Institute &
   State University; Louisiana State University System; Louisiana State
   University Health Sciences Center New Orleans; Tulane University
RP Ravussin, E (corresponding author), Pennington Biomed Res Ctr, Hlth & Human Performance Enhancement Div, 6400 Perkins Rd, Baton Rouge, LA 70808 USA.
EM ravusse@pbrc.edu
RI Rood, Jennifer/N-1989-2017; Ravussin, Eric/N-1985-2017; Ermolao,
   Andrea/I-5463-2012
OI Ermolao, Andrea/0000-0002-0546-1514
FU NIA NIH HHS [P01 AG022064] Funding Source: Medline; NIGMS NIH HHS [R37
   GM042056, R01 GM042056, P50 GM015431, P01 GM015431] Funding Source:
   Medline
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NR 28
TC 5
Z9 8
U1 0
U2 2
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0161-9152
EI 1574-4647
J9 AGE
JI Age
PD MAR
PY 2009
VL 31
IS 1
BP 67
EP 75
DI 10.1007/s11357-008-9082-z
PG 9
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA 411JD
UT WOS:000263644800007
PM 19234770
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Eshkevari, L
   Egan, R
   Phillips, D
   Tilan, J
   Carney, E
   Azzam, N
   Amri, H
   Mulroney, SE
AF Eshkevari, Ladan
   Egan, Rupert
   Phillips, Dylan
   Tilan, Jason
   Carney, Elissa
   Azzam, Nabil
   Amri, Hakima
   Mulroney, Susan E.
TI Acupuncture at ST36 prevents chronic stress-induced increases
   in neuropeptide Y in rat
SO EXPERIMENTAL BIOLOGY AND MEDICINE
LA English
DT Article
DE acupuncture; NPY; chronic stress; paraventricular nucleus
ID METABOLIC SYNDROME; COLD STRESS; IMMOBILIZATION STRESS; PSYCHOLOGICAL
   STRESS; PSYCHOSOCIAL STRESS; NPY EXPRESSION; OBESITY;
   ELECTROACUPUNCTURE; RECEPTORS; RESPONSES
AB Chronic stress, as seen in post-traumatic stress disorder, can exacerbate existing diseases. Electroacupuncture (EA) has been proposed to treat chronic stress, although information on its efficacy or mechanism(s) of action is limited. While many factors contribute to the chronic stress response, the sympathetic peptide, neuropeptide Y (NPY), has been shown to be elevated in chronic stress and is hypothesized to contribute to the physiological stress response. Our objective was to determine if EA at acupuncture point stomach 36 (ST36) is effective in mitigating cold stress-induced increase in NPY in rats. Both pretreatment and concomitant treatment with EA ST36 effectively suppressed peripheral and central NPY after 14 d of cold stress (P < 0.05). The effect was specific, as NPY in Sham-EA rats was not different than observed in stress-only rats. Additionally, the effect of EA ST36 was long-lasting, as NPY levels remained suppressed despite early cessation of EA ST36, while exposure to cold stress was continued. In the paraventricular nucleus (PVN), it was notable that changes in NPY mirrored plasma NPY levels, and that the significant elevation in PVN Y1 receptor observed with stress was also prevented with EA ST36. The findings indicate that EA ST36 is effective in preventing one of the sympathetic pathways stimulated during chronic stress, and thus may be a useful adjunct therapy in stress-related disorders.
C1 [Eshkevari, Ladan; Tilan, Jason] Georgetown Univ, Med Ctr, Dept Nursing, Sch Nursing & Hlth Studies, Washington, DC 20007 USA.
   [Egan, Rupert; Carney, Elissa; Mulroney, Susan E.] Georgetown Univ, Med Ctr, Dept Pharmacol & Physiol, Washington, DC 20007 USA.
   [Phillips, Dylan] Georgetown Univ, Med Ctr, Dept Human Sci, Sch Nursing & Hlth Studies, Washington, DC 20007 USA.
   [Azzam, Nabil] Georgetown Univ, Med Ctr, Dept Neurosci, Washington, DC 20007 USA.
   [Amri, Hakima] Georgetown Univ, Med Ctr, Dept Biochem & Cell & Mol Biol, Washington, DC 20007 USA.
C3 Georgetown University; Georgetown University; Georgetown University;
   Georgetown University; Georgetown University
RP Eshkevari, L (corresponding author), Georgetown Univ, Med Ctr, Dept Nursing, Sch Nursing & Hlth Studies, 421 St Marys Hall,4000 Reservoir Rd NW, Washington, DC 20007 USA.
EM eshkevl@georgetown.edu
RI Tilan, Justin/AAJ-7253-2021
OI Tilan, Jason/0000-0002-0454-5409
FU American Association of Nurse Anesthetists (AANA); NIH/NCCAM
   [K07-AT001193-02 NIH/NCCAM]
FX The research was funded by the American Association of Nurse
   Anesthetists (AANA) doctoral fellowship award to LE and NIH/NCCAM grant
   no. K07-AT001193-02 NIH/NCCAM to HA.
CR [Anonymous], ADH LONG TERM THER E
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NR 41
TC 33
Z9 36
U1 0
U2 22
PU ROYAL SOC MEDICINE PRESS LTD
PI LONDON
PA 1 WIMPOLE STREET, LONDON W1G 0AE, ENGLAND
SN 1535-3702
J9 EXP BIOL MED
JI Exp. Biol. Med.
PD JAN
PY 2012
VL 237
IS 1
BP 18
EP 23
DI 10.1258/ebm.2011.011224
PG 6
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 886PF
UT WOS:000299865600003
PM 22156045
DA 2025-06-11
ER

PT J
AU Chen, J
   Qin, X
   Chen, MY
   Chen, TZ
   Chen, Z
   He, BH
AF Chen, Jie
   Qin, Xiang
   Chen, Mengyao
   Chen, Tianzhu
   Chen, Zheng
   He, Beihui
TI Biological activities, Molecular mechanisms, and Clinical application of
   Naringin in Metabolic syndrome
SO PHARMACOLOGICAL RESEARCH
LA English
DT Article
DE Metabolic syndrome; Naringin; molecular mechanisms; anti-inflammatory;
   antioxidant
ID NF-KAPPA-B; GLUCOSE-INDUCED INJURIES; OXIDATIVE STRESS; PROTEIN-KINASE;
   MAPK PATHWAY; RAT MODEL; ACTIVATION; EXPRESSION; LIVER; INFLAMMATION
AB Metabolic syndrome has become major health problems in recent decades, and natural compounds receive considerable attention in the management of metabolic syndrome. Among them, naringin is abundant in citrus fruits and tomatoes. Many studies have investigated the therapeutic effects of naringin in metabolic syndrome. This review discusses in vitro and in vivo studies on naringin and implications for clinical trials on metabolic syndrome such as diabetes mellitus, obesity, nonalcoholic fatty liver disease, dyslipidemia, and hypertension over the past decades, overviews the molecular mechanisms by which naringin targets metabolic syndrome, and analyzes possible correlations between the different mechanisms. This review provides a theoretical basis for the further application of naringin in the treatment of metabolic syndrome.
C1 [Chen, Jie; Qin, Xiang; Chen, Mengyao; Chen, Tianzhu; Chen, Zheng; He, Beihui] Zhejiang Chinese Med Univ, Affiliated Hosp 1, Zhejiang Prov Hosp Chinese Med, Hangzhou 310006, Peoples R China.
   [He, Beihui] Zhejiang Chinese Med Univ, Sch Life Sci, Hangzhou 310053, Peoples R China.
C3 Zhejiang Chinese Medical University; Zhejiang Chinese Medical University
RP Chen, Z; He, BH (corresponding author), Zhejiang Chinese Med Univ, Affiliated Hosp 1, Zhejiang Prov Hosp Chinese Med, Hangzhou 310006, Peoples R China.
EM 15757872837@163.com; graf303@sina.com
FU Zhejiang Provincial Natural Science Foundation of China [LGF22H290001];
   Administration of Traditional Chinese Medicine of Zhejiang Province
   [2022ZA070, 2023ZR016, 2023ZL419]
FX This research is supported by Zhejiang Provincial Natural Science
   Foundation of China (LGF22H290001) and Administration of Traditional
   Chinese Medicine of Zhejiang Province (2022ZA070, 2023ZR016 and
   2023ZL419) .
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NR 82
TC 8
Z9 8
U1 10
U2 35
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 1043-6618
EI 1096-1186
J9 PHARMACOL RES
JI Pharmacol. Res.
PD APR
PY 2024
VL 202
AR 107124
DI 10.1016/j.phrs.2024.107124
EA MAR 2024
PG 9
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA OJ3U5
UT WOS:001206871900001
PM 38428704
OA hybrid
DA 2025-06-11
ER

PT J
AU Morell-Azanza, L
   García-Calzón, S
   Rendo-Urteaga, T
   Martin-Calvo, N
   Chueca, M
   Martínez, JA
   Azcona-Sanjulián, MC
   Marti, A
AF Morell-Azanza, Lydia
   Garcia-Calzon, Sonia
   Rendo-Urteaga, Tara
   Martin-Calvo, Nerea
   Chueca, Maria
   Alfredo Martinez, Jose
   Cristina Azcona-Sanjulian, Maria
   Marti, Amelia
TI Serum oxidized low-density lipoprotein levels are related to
   cardiometabolic risk and decreased after a weight loss treatment in
   obese children and adolescents
SO PEDIATRIC DIABETES
LA English
DT Article
DE BMI-SDS; dietary intervention; LDL-cholesterol; pediatrics
ID OXIDATIVE STRESS; CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; LDL;
   OVERWEIGHT; HEALTHY; MARKERS
AB Background and aimsThe oxidation of low-density lipoprotein (LDL) cholesterol particles is an early atherogeninic event. Obese pediatric populations have higher levels of oxidized LDL (oxLDL) than normal weight children. The aim of this study was to evaluate the effect of a weight loss program on the biochemical profile and oxLDL levels in Spanish obese children and adolescents.
   MethodsForty obese children (mean age 11 years, 51% boys) followed a 10-week weight loss program. They were dichotomized at the median of body mass index-standard deviation score (BMI-SDS) change, as high (HR) and low responders (LR) after the intervention. The intervention included a moderate energy-restricted diet, nutritional education, and family involvement. Anthropometric and biochemical measurements were performed at the beginning and during the follow up. A cardiometabolic risk score (CMS) was calculated considering metabolic risk factors.
   ResultsHigher baseline oxLDL levels were associated with a higher CMS in obese children (P<.001). After the intervention, oxLDL significantly decreased in the HR group. Moreover, a positive correlation between changes in oxLDL and BMI-SDS (r=0.385, P=.015) was found after the weight loss program. Interestingly, multiple-adjusted regression models showed an association between changes in total cholesterol [B: 0.127, 95% confidence interval (CI): 0.06 to 0.20] and LDL-cholesterol (B: 0.173, 95% CI: 0.08 to 0.26) with changes in oxLDL.
   ConclusionsHigher baseline oxLDL levels were associated with a higher CMS in obese children. After the weight loss program, a decrease in oxLDL levels was found in HR subjects and the oxLDL levels were associated with BMI-SDS and cholesterol levels.
C1 [Morell-Azanza, Lydia; Garcia-Calzon, Sonia; Alfredo Martinez, Jose; Marti, Amelia] Univ Navarra, Dept Nutr Food Sci & Physiol, Pamplona, Spain.
   [Garcia-Calzon, Sonia] Lund Univ, Epigenet & Diabet Unit, Ctr Diabet, Malmo, Sweden.
   [Garcia-Calzon, Sonia] Scania Univ Hosp, Dept Clin Sci, CRC, Malmo, Sweden.
   [Rendo-Urteaga, Tara] Univ Sao Paulo, Sch Med, Youth Child & cAdiovasc Risk & Environm YCARE Res, Sao Paulo, Brazil.
   [Martin-Calvo, Nerea] Univ Navarra, Sch Med, Dept Prevent Med & Publ Hlth, Pamplona, Spain.
   [Morell-Azanza, Lydia; Martin-Calvo, Nerea; Chueca, Maria; Alfredo Martinez, Jose; Cristina Azcona-Sanjulian, Maria; Marti, Amelia] Navarra Inst Hlth Res, IdiSNA, Pamplona, Spain.
   [Chueca, Maria] Complejo Hosp Navarra, Paediat Endocrinol Unit, Pamplona, Spain.
   [Alfredo Martinez, Jose; Marti, Amelia] Inst Hlth Carlos III, Ctr Biomed Res Physiopathol Obes & Nutr CIBEROBN, Madrid, Spain.
   [Cristina Azcona-Sanjulian, Maria] Clin Univ Navarra, Paediat Endocrinol Unit, Dept Paediat, Pamplona, Spain.
C3 University of Navarra; Lund University; Universidade de Sao Paulo;
   University of Navarra; University of Navarra; Servicio Navarro de Salud
   - Osasunbidea; CIBER - Centro de Investigacion Biomedica en Red;
   CIBEROBN; University of Navarra
RP Marti, A (corresponding author), Univ Navarra, Dept Nutr Food Sci & Physiol, Pamplona, Spain.
EM amarti@unav.es
RI Martínez, J./K-8709-2014; García Calzón, Sonia/AAA-6385-2020; Marti del
   Moral, Amelia/H-1192-2017; Martin-Calvo, Nerea/D-1727-2017; Azcona,
   Cristina/A-1160-2015; Rendo-Urteaga, Tara/I-3321-2015
OI Marti del Moral, Amelia/0000-0001-9832-7981; Morell Azanza,
   Lydia/0000-0003-1387-2679; Garcia-Calzon, Sonia/0000-0002-1249-4795;
   Martin-Calvo, Nerea/0000-0001-7549-1455; Azcona,
   Cristina/0000-0001-5534-8758; Rendo-Urteaga, Tara/0000-0002-8597-3535
FU Navarra Goverment [PI 54/2009]; PIUNA; CIBERobn (project CIBER)
   [CB06/03/1017]
FX The NUGENOI study was funded by the Navarra Goverment (PI 54/2009),
   PIUNA and CIBERobn (project CIBER, CB06/03/1017). Lydia Morell-Azanza is
   fully acknowledged for the fellowships to Asociacion de Amigos de la
   Universidad de Navarra (ADA).
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NR 33
TC 15
Z9 16
U1 0
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1399-543X
EI 1399-5448
J9 PEDIATR DIABETES
JI Pediatr. Diabetes
PD AUG
PY 2017
VL 18
IS 5
BP 392
EP 398
DI 10.1111/pedi.12405
PG 7
WC Endocrinology & Metabolism; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Pediatrics
GA EZ7KD
UT WOS:000404902100009
PM 27435258
OA gold
DA 2025-06-11
ER

PT J
AU Casagrande, D
   Waib, FF
   Elias, J Jr
   Jordao, AA Jr
AF Casagrande, Daniela
   Waib, Fernando Figueiredo
   Elias Jr, Jorge
   Jordao Jr, Alceu Afonso
TI Effects of Coenzyme Q10 Supplementation in Women with Metabolic Syndrome
   and Non-Alcoholic Fatty Liver Disease Evaluated by Magnetic Resonance
   Imaging-Coenzyme Q10 in Metabolic Syndrome and NAFLD
SO OBESITIES
LA English
DT Article
DE coenzyme Q10; metabolic syndrome X; non-alcoholic fatty liver disease;
   liver steatosis; magnetic resonance imaging
ID DOUBLE-BLIND; OXIDATIVE STRESS; LIPID PROFILES; INFLAMMATION;
   METAANALYSIS; GLUCOSE; PREVALENCE; BIOMARKERS; COMPONENTS; YOUNG
AB (1) Introduction: Coenzyme Q10 (CoQ10) is a component present in the transport chain of mitochondrial electrons with antioxidant property. Currently, there are limited studies which indicate the effects of its supplementation on Metabolic Syndrome (MetS) and Non-Alcoholic Fatty Liver Disease (NAFLD). (2) Objective: This work was conducted to determine the effects of CoQ10 supplementation in women with MetS and NAFLD. (3) Methodology: This double-blind randomized clinical-controlled trial was performed among 22 women with MetS and NAFLD. Patients were randomized into two groups: group A (n = 11), which received 200 mg/day of CoQ10; and group B (n = 11), which received a placebo medication for 12 weeks. The hepatic steatosis present in NAFLD, the volume of abdominal fat, and visceral fat volume were evaluated by Magnetic Resonance Imaging (MRI). Anthropometric, blood pressure, and marker serums that compound the MetS were also analyzed. (4) Results: A decrease in visceral fat volume (p = 0.02), abdominal circumference (p = 0.03/CI = 0.19-3.80), and increase in HDL-cholesterol (p = 0.01/CI = -9.80: -1.44) was observed in the CoQ10-supplemented group. We did not find significant changes in any of the other variables evaluated. (5) Conclusions: Supplementation with CoQ10 for 12 weeks, even if discreetly, brought some benefits for the supplemented group whereas no changes were observed in the control group.
C1 [Casagrande, Daniela; Jordao Jr, Alceu Afonso] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Hlth Sci, BR-14040900 Ribeirao Preto, SP, Brazil.
   [Waib, Fernando Figueiredo; Elias Jr, Jorge] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Med Imaging Hematol & Clin Oncol, BR-14040900 Ribeirao Preto, SP, Brazil.
C3 Universidade de Sao Paulo; Universidade de Sao Paulo
RP Casagrande, D (corresponding author), Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Hlth Sci, BR-14040900 Ribeirao Preto, SP, Brazil.
EM casagrande.dani@hotmail.com; ffwaib@gmail.com; jejunior@fmrp.usp.br;
   alceu@fmrp.usp.br
RI ; Elias Junior, Jorge/A-6683-2008
OI /0000-0003-1288-0802; Elias Junior, Jorge/0000-0002-1158-1045
FU Coordenacao de Aperfeicoamento de Pessoal de NivelSuperior (CAPES)
   [00.889.834/0001-08]
FX This work was supported by Coordenacao de Aperfeicoamento de Pessoal de
   NivelSuperior (CAPES) under grant 00.889.834/0001-08.
CR ABESO Associacao Brasileira para o Estudo da Obesidade e da Sindrome, Metabolica Mapa da Obesidade
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NR 47
TC 2
Z9 2
U1 1
U2 1
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2673-4168
J9 OBESITIES-BASEL
JI Obesities
PD JUN
PY 2024
VL 4
IS 2
BP 106
EP 117
DI 10.3390/obesities4020011
PG 12
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA D0Z1O
UT WOS:001293545600001
OA gold
DA 2025-06-11
ER

PT J
AU Bonomini, F
   Rodella, LF
   Rezzani, R
AF Bonomini, Francesca
   Rodella, Luigi Fabrizio
   Rezzani, Rita
TI Metabolic Syndrome, Aging and Involvement of Oxidative Stress
SO AGING AND DISEASE
LA English
DT Review
DE metabolic syndrome; aging; accelerated senescence; oxidative stress
ID ROSTRAL VENTROLATERAL MEDULLA; MITOCHONDRIAL-DNA MUTATIONS; MECHANISMS
   LINKING OBESITY; ACUTE GLUCOSE FLUCTUATIONS; INSULIN-RESISTANCE;
   DIABETES-MELLITUS; LIPID-PEROXIDATION; CARDIOVASCULAR-DISEASE; ABDOMINAL
   OBESITY; IN-VIVO
AB The prevalence of the metabolic syndrome, a cluster of cardiovascular risk factors associated with obesity and insulin resistance, is dramatically increasing in Western and developing countries. This disorder consists of a cluster of metabolic conditions, such as hypertriglyceridemia, hyper-low-density lipoproteins, hypo-high-density lipoproteins, insulin resistance, abnormal glucose tolerance and hypertension, that-in combination with genetic susceptibility and abdominal obesity-are risk factors for type 2 diabetes, vascular inflammation, atherosclerosis, and renal, liver and heart diseases. One of the defects in metabolic syndrome and its associated diseases is excess of reactive oxygen species. Reactive oxygen species generated by mitochondria, or from other sites within or outside the cell, cause damage to mitochondrial components and initiate degradative processes. Such toxic reactions contribute significantly to the aging process. In this article we review current understandings of oxidative stress in metabolic syndrome related disease and its possible contribution to accelerated senescence.
C1 [Bonomini, Francesca; Rodella, Luigi Fabrizio; Rezzani, Rita] Univ Brescia, Dept Clin & Expt Sci, Div Anat & Physiopathol, I-25123 Brescia, Italy.
C3 University of Brescia
RP Bonomini, F (corresponding author), Univ Brescia, Dept Clin & Expt Sci, Viale Europa 11, I-25123 Brescia, Italy.
EM bonomini@med.unibs.it
RI Francesca, Bonomini/E-9931-2010; Rodella, Luigi/F-1079-2010
OI Rodella, Luigi Fabrizio/0000-0002-9497-4708
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NR 133
TC 423
Z9 470
U1 12
U2 156
PU INT SOC AGING & DISEASE
PI FORT WORTH
PA EDITORIAL OFF, 3400 CAMP BOWIE BLVD, FORT WORTH, TX 76106 USA
SN 2152-5250
J9 AGING DIS
JI Aging Dis.
PD MAR
PY 2015
VL 6
IS 2
BP 109
EP 120
DI 10.14336/AD.2014.0305
PG 12
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA CJ5SJ
UT WOS:000355548900003
PM 25821639
OA Green Published, gold
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Nguyen, HD
   Oh, H
   Kim, MS
AF Nguyen, Hai Duc
   Oh, Hojin
   Kim, Min-Sun
TI Effect of Mixture of Heavy Metals on Metabolic Syndrome and Its
   Components in Individuals ≥ 18Years of Age: From Big Data to Molecular
   Mechanisms Involved
SO EXPOSURE AND HEALTH
LA English
DT Article
DE Metabolic syndrome; Heavy metals; Chemical mixture; Threshold; Molecular
   mechanisms
ID BLOOD MERCURY LEVELS; LEAD CONCENTRATIONS; OXIDATIVE STRESS; CHILDREN;
   CADMIUM; EXPOSURE; ASSOCIATION; OBESITY; RISK; GENE
AB Scarce information exists about the link between mixed heavy metals and metabolic syndrome (MetS) and its components, as well as its molecular mechanism. Thus, we identified the associations of serum cadmium, lead, and mercury with MetS and its components using linear regression models, weighted quantile sum (WQS) regression, quantile g-computation (qgcomp), and Bayesian kernel machine regression (BKMR). Of the 5581 subjects included, 30.8% had MetS. In the logistic regression model, serum mercury was associated with MetS and its components, and significant trends were observed for these heavy metal quantiles (p < 0.001). Serum mercury levels were also linked with MetS and its components in the WQS and qgcomp models. In BKMR analysis, the overall effect of the mixture was significantly associated with MetS and its components. Serum mercury showed positive trends and was observed as the most important factor associated with MetS, along with elevated waist circumference and elevated blood pressure. In in-silico toxicogenomic data mining, we found several pathways (insulin resistance, IL6 signaling pathway, and adipogenesis), regulation of lipid localization, and metabolic syndrome X as key molecular mechanisms that may be affected by heavy metals and involved in the development of MetS. We identified hsa-miR-124-3p as the highest interaction and expression implicated in the MetS process. We also used miRNAsong to create and test a miRNA sponge sequence for these miRNAs, which may be promising for being used in MetS therapy. In particular, the cutoff levels for exposure levels related to MetS and its components were also reported.
C1 [Nguyen, Hai Duc; Oh, Hojin; Kim, Min-Sun] Sunchon Natl Univ, Coll Pharm, Dept Pharm, Sunchon 57922, Jeonnam, South Korea.
   [Nguyen, Hai Duc; Oh, Hojin; Kim, Min-Sun] Sunchon Natl Univ, Res Inst Life & Pharmaceut Sci, Sunchon 57922, Jeonnam, South Korea.
C3 Sunchon National University; Sunchon National University
RP Nguyen, HD; Kim, MS (corresponding author), Sunchon Natl Univ, Coll Pharm, Dept Pharm, Sunchon 57922, Jeonnam, South Korea.; Nguyen, HD; Kim, MS (corresponding author), Sunchon Natl Univ, Res Inst Life & Pharmaceut Sci, Sunchon 57922, Jeonnam, South Korea.
EM duchainguyen1706@gmail.com; minsun@scnu.ac.kr
RI Oh, Hojin/ABA-7781-2021; Nguyen Duc, Hai/AAD-8210-2020
OI Nguyen Duc, Hai/0000-0001-8419-7784
FU National Research Foundation of Korea (NRF) [2022R1A2C1005643]
FX This study supported by National Research Foundation of Korea (NRF)
   (Grant No. 2022R1A2C1005643).
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NR 71
TC 6
Z9 6
U1 4
U2 19
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 2451-9766
EI 2451-9685
J9 EXPOS HEALTH
JI Expo. Health
PD DEC
PY 2023
VL 15
IS 4
BP 773
EP 805
DI 10.1007/s12403-022-00523-y
EA DEC 2022
PG 33
WC Water Resources
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Water Resources
GA AY5O7
UT WOS:000919478800002
DA 2025-06-11
ER

PT J
AU Morris, AA
   Zhao, LP
   Patel, RS
   Jones, DP
   Ahmed, Y
   Stoyanova, N
   Gibbons, GH
   Vaccarino, V
   Din-Dzietham, R
   Quyyumi, AA
AF Morris, Alanna A.
   Zhao, Liping
   Patel, Riyaz S.
   Jones, Dean P.
   Ahmed, Yusuf
   Stoyanova, Neli
   Gibbons, Gary H.
   Vaccarino, Viola
   Din-Dzietham, Rebecca
   Quyyumi, Arshed A.
TI Differences in Systemic Oxidative Stress Based on Race and the Metabolic
   Syndrome: The Morehouse and Emory Team up to Eliminate Health
   Disparities (META-Health) Study
SO METABOLIC SYNDROME AND RELATED DISORDERS
LA English
DT Article
ID C-REACTIVE PROTEIN; HUMAN PLASMA; ENDOTHELIAL FUNCTION; ETHNIC-GROUPS;
   OXIDIZED LDL; RISK-FACTORS; GLUTATHIONE; ATHEROSCLEROSIS; DISEASE;
   MARKERS
AB Background: Classification schema such as metabolic syndrome may underestimate cardiovascular disease (CVD) risk in African Americans, despite a higher burden of CVD in African Americans. Oxidative stress results from an imbalance of prooxidants and antioxidants and leads to endothelial dysfunction that promotes vascular inflammation and atherosclerosis. Aminothiol markers of oxidative stress are associated with CVD risk factors and metabolic syndrome; however, little is known about racial differences in levels of oxidative stress. We sought to investigate whether oxidative stress would be higher in African Americans compared to whites independently of traditional risk factor burden.
   Methods: We assessed oxidative stress in a biracial, community-based cohort. In 620 subjects (59% female, 52% African American) in the Morehouse and Emory Team up to Eliminate Health Disparities (META-Health) study, we measured plasma levels of glutathione, an intracellular antioxidant, and its redox potential as a ratio of reduced and oxidized glutathione (Eh glutathione).
   Results: African Americans had lower glutathione levels (P < 0.001) compared to whites. There was a trend toward more oxidized Eh glutathione (P = 0.07) in African Americans; however, this did not reach statistical significance. After adjustment for demographics and CVD risk factors, African-American race remained a significant correlate of lower glutathione levels (P < 0.001) and a more oxidized Eh glutathione (P = 0.04). After further adjustment for high-sensitivity C-reactive protein (hsCRP), glutathione remained significantly lower in African Americans (P = 0.001). African Americans with or without metabolic syndrome had lower glutathione levels compared to whites with or without metabolic syndrome, respectively (both P <= 0.001), and African Americans without metabolic syndrome had a more oxidized Eh glutathione compared to whites without metabolic syndrome (P = 0.003).
   Conclusions: African Americans have higher levels of oxidative stress than whites, even after adjustment for differences in CVD risk factors and inflammation. Racial differences in oxidative stress may play a key role in understanding observed racial disparities in CVD.
C1 [Morris, Alanna A.; Patel, Riyaz S.; Ahmed, Yusuf; Quyyumi, Arshed A.] Emory Univ, Sch Med, Div Cardiol, Atlanta, GA 30322 USA.
   [Zhao, Liping; Vaccarino, Viola] Emory Rollins Sch Publ Hlth, Div Epidemiol, Atlanta, GA USA.
   [Jones, Dean P.] Emory Univ, Sch Med, Div Pulm Allergy & Crit Care Med, Atlanta, GA USA.
   [Stoyanova, Neli; Gibbons, Gary H.; Din-Dzietham, Rebecca] Morehouse Sch Med, Cardiovasc Res Inst, Atlanta, GA 30310 USA.
C3 Emory University; Emory University; Rollins School Public Health; Emory
   University; Morehouse School of Medicine
RP Morris, AA (corresponding author), 1462 Clifton Rd NE,Suite 507, Atlanta, GA 30322 USA.
EM aamorr3@emory.edu
RI Vaccarino, Viola/AAW-5600-2020
OI Vaccarino, Laura Viola/0000-0002-9054-0654
FU National Institutes of Health/National Heart, Blood, and Lung Institute
   (NIH/NHLBI) [1 U01 HL079156-01, 1 U01 HL79214-01]; NIH, National Center
   for Research Resources (NCRR) Grant [M01-RR00039]; NIH/NCRR
   [5P20RR11104, 5U54RR022814]; NIH [K24HL077506-06]
FX The authors thank the META-Health study population and Emory and
   Morehouse GCRC staff for their assistance and participation. This work
   was supported by funding from National Institutes of Health/National
   Heart, Blood, and Lung Institute (NIH/NHLBI) 1 U01 HL079156-01 (Quyyumi)
   and 1 U01 HL79214-01 (Gibbons); NIH, National Center for Research
   Resources (NCRR) Grant M01-RR00039 for the Emory General Clinical
   Research Center (GCRC); NIH/NCRR 5P20RR11104 for the Morehouse CRC; NIH
   K24HL077506-06 (Vaccarino); and NIH/NCRR 5U54RR022814 (Din).
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NR 36
TC 67
Z9 77
U1 0
U2 4
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-4196
EI 1557-8518
J9 METAB SYNDR RELAT D
JI Metab. Syndr. Relat. Disord.
PD AUG
PY 2012
VL 10
IS 4
BP 252
EP 259
DI 10.1089/met.2011.0117
PG 8
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 976OR
UT WOS:000306594700003
PM 22385338
OA Green Published
DA 2025-06-11
ER

PT J
AU Francisqueti, FV
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   Ferron, AJT
   Ferreira, ALA
   Corrêa, CR
AF Francisqueti, Fabiane Valentini
   Talon Chiaverini, Lidiana Camargo
   dos Santos, Klinsmann Carolo
   Minatel, Igor Otavio
   Ronchi, Carolina Berchieri
   Togneri Ferron, Artur Junio
   Ferreira, Ana Lucia A.
   Correa, Camila Renata
TI The role of oxidative stress on the pathophysiology of metabolic
   syndrome
SO REVISTA DA ASSOCIACAO MEDICA BRASILEIRA
LA English
DT Review
DE oxidative stress; metabolic syndrome; obesity
ID MEDITERRANEAN DIET; INSULIN-RESISTANCE; ADIPOSE-TISSUE; ADIPOCYTE SIZE;
   DNA-DAMAGE; ANTIOXIDANT; INFLAMMATION; OBESITY; INTERVENTION; EXERCISE
AB Metabolic syndrome (MetS) has a high prevalence around the world. Considering the components used to classify MetS, it is clear that it is closely related to obesity. These two conditions begin with an increase in abdominal adipose tissue, which is metabolically more active, containing a greater amount of resident macrophages compared to other fat deposits. Abdominal adiposity promotes inflammation and oxidative stress, which are precursors of various complications involving MetS components, namely insulin resistance, hypertension and hyperlipidemia. One way to block the effects of oxidative stress would be through the antioxidant defense system, which offsets the excess free radicals. It is known that individuals with metabolic syndrome and obesity have high consumption of fats and sugars originated from processed foods containing high levels of sodium as well as low intake of fruits and vegetables, thus maintaining a state of oxidative stress, that can speed up the onset of MetS. Healthy eating habits could prevent or delay MetS by adding antioxidant-rich foods into the diet.
C1 [Francisqueti, Fabiane Valentini; dos Santos, Klinsmann Carolo] Univ Estadual Paulista, UNESP, Fac Med Botucatu, Dept Pathol, Botucatu, SP, Brazil.
   [Talon Chiaverini, Lidiana Camargo] UNESP, Fac Med Botucatu, Dept Pathol, Botucatu, SP, Brazil.
   [Minatel, Igor Otavio] UNESP, Inst Biociencias Botucatu, Dept Chem & Biochem, Botucatu, SP, Brazil.
   [Ronchi, Carolina Berchieri; Togneri Ferron, Artur Junio; Ferreira, Ana Lucia A.] UNESP, Fac Med Botucatu, Dept Internal Med, Botucatu, SP, Brazil.
   [Correa, Camila Renata] UNESP, Fac Med Botucatu, Dept Pathol, Pathol Grad Program, Botucatu, SP, Brazil.
C3 Universidade Estadual Paulista; Universidade Estadual Paulista;
   Instituto de Botanica - Sao Paulo; Universidade Estadual Paulista;
   Universidade Estadual Paulista; Universidade Estadual Paulista
RP Francisqueti, FV (corresponding author), Av Prof Montenegro Distrito de Rubiao Jr S-N, BR-18618970 Botucatu, SP, Brazil.
EM fabianevf@gmail.com
RI Correa, Camila/Q-2071-2019; dos Santos, Klinsmann/O-2088-2014; Minatel,
   Igor/A-9094-2016; Francisqueti, Fabiane/AAY-8977-2020; Francisqueti-
   Ferron, Fabiane/M-4919-2017; Ferron, Artur Junio/M-5194-2017
OI Francisqueti- Ferron, Fabiane/0000-0003-2910-4308; Ferron, Artur
   Junio/0000-0001-7089-3033; Correa, Camila Renata/0000-0001-8493-5329
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NR 63
TC 73
Z9 78
U1 0
U2 17
PU ASSOC MEDICA BRASILEIRA
PI SAO PAULO
PA RUA SAO CARLOS DO PINHAL 324, CAIXA POSTAL 8904, SAO PAULO, SP, BRAZIL
EI 1806-9282
J9 REV ASSOC MED BRAS
JI Rev. Assoc. Med. Bras.
PD JAN
PY 2017
VL 63
IS 1
BP 85
EP 91
DI 10.1590/1806-9282.63.01.85
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA EL3KG
UT WOS:000394517400016
PM 28225880
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Salari-Moghaddam, A
   Keshteli, AH
   Afshar, H
   Esmaillzadeh, A
   Adibi, P
AF Salari-Moghaddam, Asma
   Keshteli, Ammar Hassanzadeh
   Afshar, Hamid
   Esmaillzadeh, Ahmad
   Adibi, Peyman
TI Association between dietary inflammatory index and psychological profile
   in adults
SO CLINICAL NUTRITION
LA English
DT Article
DE Dietary inflammatory index; DII; Inflammation; Psychological profile;
   Epidemiology
ID CARDIOVASCULAR-DISEASE RISK; C-REACTIVE PROTEIN; MENTAL-DISORDERS;
   DEPRESSIVE SYMPTOMS; METABOLIC SYNDROME; CANCER; POPULATION;
   METAANALYSIS; OBESITY; WOMEN
AB Background & aims: Limited data are available on the association of inflammatory potential of the diet and odds of psychological disorders. We investigated the association between adherence to a pro-inflammatory diet, as measured by Dietary Inflammatory Index (DII), and odds of psychological disorders.
   Methods: In this cross-sectional study, dietary intakes of 3363 Iranian adult participants were collected using a validated Dish-based 106-item Semi-quantitative Food Frequency Questionnaire (DS-FFQ). DII score was calculated based on participants' dietary intakes obtained from DS-FFQ. The Iranian validated version of Hospital Anxiety and Depression Scale (HADS) and General Health Questionnaire (GHQ) was used to assess psychological disorders. For depression and anxiety, scores of 8 or more on either subscale were considered as psychological disorders and scores of 0-7 were defined as "normal". In terms of psychological distress, the score of 4 or more was defined as psychological distress.
   Results: Overall, 28% (n = 943) of study participants had depression, 13.3% (n = 448) were affected by anxiety and 22.6% (n = 760) by psychological distress. After controlling for potential confounders, individuals in the highest quintile of DII score had higher scores of depression (6.56 +/- 0.16 vs. 5.48 +/- 0.16; P < 0.001), anxiety (3.85 +/- 0.17 vs. 3.09 +/- 0.17; P = 0.006), and psychological distress (2.42 +/- 0.13 vs. 1.77 +/- 0.13; P = 0.001), compared with those in the lowest quintile. Participants in the top quintile of DII score had greater odds of depression (OR: 1.84, 95% CI: 1.30-2.60), anxiety (OR: 1.69, 95% CI: 1.07-2.67), and psychological distress (OR: 1.72, 95% CI: 1.20-2.46) than those in the bottom quintile.
   Conclusions: We found that adherence to a pro-inflammatory diet was positively associated with psychological disorders. (C) 2018 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.
C1 [Salari-Moghaddam, Asma] Univ Tehran Med Sci, Students Sci Res Ctr, Tehran, Iran.
   [Salari-Moghaddam, Asma; Esmaillzadeh, Ahmad] Univ Tehran Med Sci, Dept Community Nutr, Sch Nutr Sci & Dietet, POB 14155-6117, Tehran, Iran.
   [Keshteli, Ammar Hassanzadeh] Univ Alberta, Dept Med, Edmonton, AB, Canada.
   [Keshteli, Ammar Hassanzadeh; Adibi, Peyman] Isfahan Univ Med Sci, Integrat Funct Gastroenterol Res Ctr, Esfahan, Iran.
   [Afshar, Hamid] Isfahan Univ Med Sci, Psychosomat Res Ctr, Dept Psychiat, Esfahan, Iran.
   [Esmaillzadeh, Ahmad] Univ Tehran Med Sci, Endocrinol & Metab Mol Cellular Sci Inst, Obes & Eating Habits Res Ctr, Tehran, Iran.
   [Esmaillzadeh, Ahmad] Isfahan Univ Med Sci, Sch Nutr & Food Sci, Dept Community Nutr, Esfahan, Iran.
C3 Tehran University of Medical Sciences; Tehran University of Medical
   Sciences; University of Alberta; Isfahan University of Medical Sciences;
   Isfahan University of Medical Sciences; Tehran University of Medical
   Sciences; Isfahan University of Medical Sciences
RP Esmaillzadeh, A (corresponding author), Univ Tehran Med Sci, Dept Community Nutr, Sch Nutr Sci & Dietet, POB 14155-6117, Tehran, Iran.
EM a-esmaillzadeh@tums.ac.ir
RI Salari-Moghaddam, Asma/AAH-7834-2019; Keshteli, Ammar/K-7473-2012;
   Esmaillzadeh, Ahmad/N-5704-2014; Adibi Sedeh, Peyman/AAJ-4582-2020
OI Hassanzadeh Keshteli, Ammar/0000-0001-7375-6210; Salari-Moghaddam,
   Asma/0000-0002-3999-8803; Adibi Sedeh, Peyman/0000-0001-6411-5235
FU School of Nutritional Sciences and Dietetics, Tehran University of
   Medical Sciences, Tehran, Iran [9321324004]
FX This study was extracted from a PhD dissertation that was approved by
   School of Nutritional Sciences and Dietetics, Tehran University of
   Medical Sciences, Tehran, Iran (code 9321324004). The authors are
   thankful to participants of SEPAHAN project and authorities of Isfahan
   University of Medical Sciences for their excellent cooperation.
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NR 49
TC 36
Z9 37
U1 0
U2 9
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0261-5614
EI 1532-1983
J9 CLIN NUTR
JI Clin. Nutr.
PD OCT
PY 2019
VL 38
IS 5
BP 2360
EP 2368
DI 10.1016/j.clnu.2018.10.015
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nutrition & Dietetics
GA JH5GR
UT WOS:000492797600048
PM 30415907
DA 2025-06-11
ER

PT J
AU Bauman, A
   Merom, D
   Bull, FC
   Buchner, DM
   Singh, MAF
AF Bauman, Adrian
   Merom, Dafna
   Bull, Fiona C.
   Buchner, David M.
   Singh, Maria A. Fiatarone
TI Updating the Evidence for Physical Activity: Summative Reviews of the
   Epidemiological Evidence, Prevalence, and Interventions to Promote
   "Active Aging"
SO GERONTOLOGIST
LA English
DT Review
DE Physical activity; Older adults; Evidence; Integrated review
ID FRAIL OLDER-ADULTS; QUALITY-OF-LIFE; TYPE-2 DIABETES-MELLITUS; EXERCISE
   INTERVENTIONS; RESISTANCE EXERCISE; PARKINSONS-DISEASE; COGNITIVE
   DECLINE; ALZHEIMER-DISEASE; ACTIVITY PROGRAMS; MUSCLE STRENGTH
AB Purpose of the Study: There is a global imperative to increase awareness of the emerging evidence on physical activity (PA) among older adults. "Healthy aging" has traditionally focused on preventing chronic disease, but greater efforts are required to reduce frailty and dependency and to maintain independent physical and cognitive function and mental health and well-being.
   Design and Methods: This integrated review updates the epidemiological data on PA, summarizes the existing evidence-based PA guidelines, describes the global magnitude of inactivity, and finally describes the rationale for action. The first section updates the epidemiological evidence for reduced cardiometabolic risk, reduced risks of falls, the burgeoning new evidence on improved cognitive function and functional capacity, and reduced risk of depression, anxiety, and dementia. This is followed by a summary of population prevalence studies among older adults. Finally, we present a "review of reviews" of PA interventions delivered from community or population settings, followed by a consideration of interventions among the "oldest-old," where efforts are needed to increase resistance (strength) training and balance.
   Results: This review identifies the global importance of considering " active aging" beyond the established benefits attributed to noncommunicable disease prevention alone.
   Implications: Innovative population-level efforts are required to address physical inactivity, prevent loss of muscle strength, and maintain balance in older adults. Specific investment in healthy aging requires global policy support from the World Health Organization and is implemented at the national and regional levels, in order to reduce the burden of disease and disability among older adults.
C1 [Bauman, Adrian] Univ Sydney, Sch Publ Hlth, Level 6,Charles Perkins Ctr,D17, Sydney, NSW 2006, Australia.
   [Merom, Dafna] Univ Western Sydney, Sch Sci & Hlth, Penrith, NSW 1797, Australia.
   [Bull, Fiona C.] Univ Western Australia, Ctr Built Environm & Hlth, Perth, WA 6009, Australia.
   [Buchner, David M.] Univ Illinois, Dept Kinesiol & Community Hlth, Urbana, IL USA.
   [Singh, Maria A. Fiatarone] Univ Sydney, Fac Hlth Sci, Exercise Hlth & Performance, Level 6,Charles Perkins Ctr,D17, Sydney, NSW 2006, Australia.
C3 University of Sydney; Western Sydney University; University of Western
   Australia; University of Illinois System; University of Illinois
   Urbana-Champaign; University of Sydney
RP Bauman, A (corresponding author), Univ Sydney, Sch Publ Hlth, Level 6,Charles Perkins Ctr,D17, Sydney, NSW 2006, Australia.
EM adrian.bauman@sydney.edu.au
RI Bauman, Adrian/K-8988-2015; Bull, Fiona/G-4148-2012; Merom,
   Dafna/AAW-5357-2021
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NR 119
TC 481
Z9 535
U1 14
U2 293
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0016-9013
EI 1758-5341
J9 GERONTOLOGIST
JI Gerontologist
PD APR
PY 2016
VL 56
SU 2
BP S268
EP S280
DI 10.1093/geront/gnw031
PG 13
WC Gerontology
WE Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA DJ5BQ
UT WOS:000374222200010
PM 26994266
OA Green Published, Bronze
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Obermeyer, CM
   Bott, S
   Sassine, AJ
AF Obermeyer, Carla Makhlouf
   Bott, Sarah
   Sassine, Anniebelle J.
TI Arab Adolescents: Health, Gender, and Social Context
SO JOURNAL OF ADOLESCENT HEALTH
LA English
DT Review
DE Adolescents; Arab countries; Burden of disease; Risk factors; Gender;
   Social factors; Violence; Mental health
ID FEMALE UNIVERSITY-STUDENTS; SECONDARY-SCHOOL PUPILS; SEAT-BELT USE;
   PHYSICAL-ACTIVITY; NUTRITION TRANSITION; METABOLIC SYNDROME;
   MENTAL-HEALTH; SAUDI-ARABIA; RISK-FACTORS; DIETARY HABITS
AB This article reviews the evidence about adolescent health in the Arab world, against the background of social, economic, and political change in the region, and with a particular focus on gender. For the literature review, searches were conducted for relevant articles, and data were drawn from national population-and school-based surveys and from the Global Burden of Disease project. In some parts of the Arab world, adolescents experience a greater burden of ill health due to overweight/obesity, transport injuries, cardiovascular and metabolic conditions, and mental health disorders than those in other regions of the world. Poor diets, insufficient physical activity, tobacco use, road traffic injuries, and exposure to violence are major risk factors. Young men have higher risks of unsafe driving and tobacco use and young women have greater ill-health due to depression. Several features of the social context that affect adolescent health are discussed, including changing life trajectories and gender roles, the mismatch between education and job opportunities, and armed conflict and interpersonal violence. Policy makers need to address risk factors behind noncommunicable disease among adolescents in the Arab region, including tobacco use, unhealthy diets, sedentary lifestyles, unsafe driving, and exposure to violence. More broadly, adolescents need economic opportunity, safe communities, and a chance to have a voice in their future. (C) 2015 Society for Adolescent Health and Medicine. All rights reserved.
C1 [Obermeyer, Carla Makhlouf; Bott, Sarah; Sassine, Anniebelle J.] Amer Univ Beirut, Ctr Res Populat & Hlth, Fac Hlth Sci, Beirut, Lebanon.
C3 American University of Beirut
RP Obermeyer, CM (corresponding author), Amer Univ Beirut, Ctr Res Populat & Hlth, Fac Hlth Sci, POB 11-0236, Beirut, Lebanon.
EM cm39@aub.edu.lb
RI Bott, Sarah/LNR-2601-2024
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NR 167
TC 60
Z9 68
U1 0
U2 30
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1054-139X
EI 1879-1972
J9 J ADOLESCENT HEALTH
JI J. Adolesc. Health
PD SEP
PY 2015
VL 57
IS 3
BP 252
EP 262
DI 10.1016/j.jadohealth.2015.01.002
PG 11
WC Psychology, Developmental; Public, Environmental & Occupational Health;
   Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Public, Environmental & Occupational Health; Pediatrics
GA CP8CK
UT WOS:000360118500002
PM 25770651
DA 2025-06-11
ER

PT J
AU Phillips, CM
   Chen, LW
   Heude, B
   Bernard, JY
   Harvey, NC
   Duijts, L
   Mensink-Bout, SM
   Polanska, K
   Mancano, G
   Suderman, M
   Shivappa, N
   Hébert, JR
AF Phillips, Catherine M.
   Chen, Ling-Wei
   Heude, Barbara
   Bernard, Jonathan Y.
   Harvey, Nicholas C.
   Duijts, Liesbeth
   Mensink-Bout, Sara M.
   Polanska, Kinga
   Mancano, Giulia
   Suderman, Matthew
   Shivappa, Nitin
   Hebert, James R.
TI Dietary Inflammatory Index and Non-Communicable Disease Risk: A
   Narrative Review
SO NUTRIENTS
LA English
DT Review
DE dietary inflammatory index; inflammation; cardiometabolic health;
   obesity; metabolic syndrome; cancer; respiratory health; bone health;
   mental health; neurodevelopment
ID C-REACTIVE PROTEIN; BONE-MINERAL DENSITY; PROSTATE-CANCER RISK; MATERNAL
   DEPRESSION SYMPTOMS; POLYUNSATURATED FATTY-ACIDS; LOW-GRADE
   INFLAMMATION; NITRATIVE DNA-DAMAGE; SQUAMOUS-CELL CANCER; AGED 16-24
   MONTHS; COLORECTAL-CANCER
AB There are over 1,000,000 publications on diet and health and over 480,000 references on inflammation in the National Library of Medicine database. In addition, there have now been over 30,000 peer-reviewed articles published on the relationship between diet, inflammation, and health outcomes. Based on this voluminous literature, it is now recognized that low-grade, chronic systemic inflammation is associated with most non-communicable diseases (NCDs), including diabetes, obesity, cardiovascular disease, cancers, respiratory and musculoskeletal disorders, as well as impaired neurodevelopment and adverse mental health outcomes. Dietary components modulate inflammatory status. In recent years, the Dietary Inflammatory Index (DII (R)), a literature-derived dietary index, was developed to characterize the inflammatory potential of habitual diet. Subsequently, a large and rapidly growing body of research investigating associations between dietary inflammatory potential, determined by the DII, and risk of a wide range of NCDs has emerged. In this narrative review, we examine the current state of the science regarding relationships between the DII and cancer, cardiometabolic, respiratory and musculoskeletal diseases, neurodevelopment, and adverse mental health outcomes. We synthesize the findings from recent studies, discuss potential underlying mechanisms, and look to the future regarding novel applications of the adult and children's DII (C-DII) scores and new avenues of investigation in this field of nutritional research.
C1 [Phillips, Catherine M.; Chen, Ling-Wei] Univ Coll Dublin, HRB Ctr Diet & Hlth Res, Sch Publ Hlth Physiotherapy & Sports Sci, Dublin 4, Ireland.
   [Phillips, Catherine M.] Univ Coll Cork, HRB Ctr Diet & Hlth Res, Sch Publ Hlth, Western Gateway Bldg,Western Rd, Cork, Cork, Ireland.
   [Heude, Barbara; Bernard, Jonathan Y.] Univ Paris, INSERM, Ctr Res Epidemiol & Stat CRESS, Res Team Early Life Origins Hlth EAROH, F-94807 Villejuif, France.
   [Harvey, Nicholas C.] Univ Southampton, Southampton Gen Hosp, MRC, Lifecourse Epidemiol Unit, Southampton SO16 6YD, Hants, England.
   [Duijts, Liesbeth; Mensink-Bout, Sara M.] Univ Med Ctr, Erasmus MC, Generat R Study Grp, POB 2040, NL-3000 CA Rotterdam, Netherlands.
   [Duijts, Liesbeth; Mensink-Bout, Sara M.] Univ Med Ctr, Erasmus MC, Div Resp Med & Allergol, Dept Pediat, POB 2060, NL-3000 CB Rotterdam, Netherlands.
   [Duijts, Liesbeth] Univ Med Ctr, Erasmus MC, Dept Pediat, Div Neonatol, POB 2060, NL-3000 CB Rotterdam, Netherlands.
   [Polanska, Kinga] Nofer Inst Occupat Med, Dept Environm Epidemiol, PL-91348 Lodz, Poland.
   [Mancano, Giulia; Suderman, Matthew] Univ Bristol, Bristol Med Sch, Integrat Epidemiol Unit, MRC,Populat Hlth Sci, Bristol BS8 2BN, Avon, England.
   [Shivappa, Nitin; Hebert, James R.] Univ South Carolina, Arnold Sch Publ Hlth, Canc Prevent & Control Program, Columbia, SC 29208 USA.
   [Shivappa, Nitin; Hebert, James R.] Univ South Carolina, Arnold Sch Publ Hlth, Dept Epidemiol & Biostat, Columbia, SC 29208 USA.
   [Hebert, James R.] Connecting Hlth Innovat LLC, Columbia, SC 29201 USA.
C3 Health Research Board - Ireland; University College Dublin; Health
   Research Board - Ireland; University College Cork; Institut National de
   la Sante et de la Recherche Medicale (Inserm); Universite Paris Cite;
   University of Southampton; Erasmus University Rotterdam; Erasmus MC;
   Erasmus University Rotterdam; Erasmus MC; Erasmus University Rotterdam;
   Erasmus MC; Nofer Institute of Occupational Medicine; University of
   Bristol; University of South Carolina System; University of South
   Carolina Columbia; University of South Carolina System; University of
   South Carolina Columbia; Connecting Health Innovations LLC
RP Phillips, CM (corresponding author), Univ Coll Dublin, HRB Ctr Diet & Hlth Res, Sch Publ Hlth Physiotherapy & Sports Sci, Dublin 4, Ireland.; Phillips, CM (corresponding author), Univ Coll Cork, HRB Ctr Diet & Hlth Res, Sch Publ Hlth, Western Gateway Bldg,Western Rd, Cork, Cork, Ireland.
EM catherine.phillips@ucd.ie
RI Harvey, Nicholas/JWO-4341-2024; Hebert, James/IUO-5628-2023; Shivappa,
   Nitin/X-2215-2018; Polanska, Kinga/F-7599-2010; Bernard,
   Jonathan/T-7064-2017; Phillips, Catherine/E-4412-2013; Chen,
   Ling-Wei/D-5559-2016; Heude, Barbara/G-3095-2016
OI Phillips, Catherine/0000-0003-4916-4463; Duijts,
   Liesbeth/0000-0001-6731-9452; Suderman, Matthew/0000-0002-2715-9930;
   Chen, Ling-Wei/0000-0002-2661-8752; Bernard,
   Jonathan/0000-0002-6418-983X; Heude, Barbara/0000-0002-1565-1629;
   Harvey, Nicholas/0000-0002-8194-2512; Polanska,
   Kinga/0000-0002-3212-2307
FU European Union [696295]; Science Foundation Ireland, Ireland
   [SFI/16/ERA-HDHL/3360]; UK Biotechnology and Biological Sciences
   Research Council (ERA-HDHL Biomarkers: BBSRC) [BB/P028179/1,
   BB/P028187/1]; Polish National Centre for Research and Development
   [ERA-HDHL/01/ALPHABET/1/2017]; ZonMW The Netherlands [529051014];
   ALPHABET project [696295]; French National Agency of Research
   [AnrR16227KK]; Irish Health Research Board [HRC/2007/13]; BBSRC
   [BB/P028179/1, BB/P028187/1] Funding Source: UKRI; EPSRC [EP/J008192/1]
   Funding Source: UKRI; MRC [MC_UU_12011/2, MC_UP_A620_1015, G0400491,
   MC_U147585819, MC_U147585827] Funding Source: UKRI
FX This work was supported by an award from the European Union's Horizon
   2020 research and innovation programme under the ERA-Net Cofund of the
   Joint Programming Initiative Healthy Diet for Healthy Life (JPI-HDHL)
   (http://www.healthydietforhealthylife.eu) action number 696295
   (Biomarkers for Nutrition and Health). Co-funding was provided by
   Science Foundation Ireland, Ireland (Grant Number SFI/16/ERA-HDHL/3360),
   the UK Biotechnology and Biological Sciences Research Council (ERA-HDHL
   Biomarkers: BBSRC: BB/P028179/1 and BB/P028187/1), the Polish National
   Centre for Research and Development (ERA-HDHL/01/ALPHABET/1/2017), the
   ZonMW The Netherlands (no 529051014; 2017)) ALPHABET project (no 696295;
   2017) and the French National Agency of Research (reference
   AnrR16227KK). Funding was also provided by a research grant from the
   Irish Health Research Board (reference HRC/2007/13). The funders had no
   role in the design of the study; in the collection, analyses, or
   interpretation of data; in the writing of the manuscript, or in the
   decision to publish the results.
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NR 313
TC 233
Z9 244
U1 7
U2 119
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD AUG
PY 2019
VL 11
IS 8
AR 1873
DI 10.3390/nu11081873
PG 32
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nutrition & Dietetics
GA IV8HH
UT WOS:000484506000072
PM 31408965
OA Green Submitted, Green Published, gold
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Zeraattalab-Motlagh, S
   Jayedi, A
   Shab-Bidar, S
AF Zeraattalab-Motlagh, Sheida
   Jayedi, Ahmad
   Shab-Bidar, Sakineh
TI The effects of resveratrol supplementation in patients with type 2
   diabetes, metabolic syndrome, and nonalcoholic fatty liver disease: an
   umbrella review of meta-analyses of randomized controlled trials
SO AMERICAN JOURNAL OF CLINICAL NUTRITION
LA English
DT Review
DE resveratrol; risk factors; meta-analysis; review; antioxidants;
   randomized controlled trials
ID INSULIN-RESISTANCE; CARDIOVASCULAR-DISEASE; OXIDATIVE STRESS;
   BLOOD-PRESSURE; LIPID PROFILE; RISK-FACTORS; QUALITY; GRADE; OBESITY;
   INFLAMMATION
AB Background: Uncertainty remains about the estimates of the effects for resveratrol supplementation, including the certainty of the evidence for each estimate and the magnitude of the observed impact based on the minimal important difference.
   Objective: We aimed to provide an overview of the effects of resveratrol supplementation, in comparison to control groups, for the management of cardiometabolic risk factors in patients with type 2 diabetes (T2D), metabolic syndrome (MetS), and nonalcoholic fatty liver disease (NAFLD).
   Methods: PubMed, Scopus, and ISI Web of Science were searched from inception to May 2021. For each meta-analysis, the mean difference and its 95% CI were recalculated using a random-effects model. The certainty of evidence was rated using the GRADE (Grading of Recommendations Assessment, Development, and Evaluation) approach.
   Results: We identified 11 meta-analyses corresponding to 29 outcomes in 1476 individuals with T2D, 17 meta-analyses reporting 26 outcomes in 727 participants with the MetS, and 10 meta-analyses reporting 24 outcomes in 271 patients with NAFLD. Resveratrol supplementation had beneficial effects on some outcomes such as blood pressure, lipid profile, glycemic control, and insulin resistance in T2D, waist circumference in MetS, and body-weight and inflammation markers in NAFLD; however, for almost all outcomes, the magnitude of the effect was trivial, the certainty of evidence was very low to low, or the number of trials was too few. In the case of glycated hemoglobin (HbA1c). there was evidence that resveratrol can exert favorable and clinically important effects in the short term ( <12 wk; mean difference: -1.05%, 95% CI: -2.09%, - 0.02%; n = 6; GRADE = moderate).
   Conclusions: Current evidence does not support supplementation with resveratrol for the management of cardiometabolic risk factors in patients with T2D, MetS, and NAFLD. In the case of HbA1c, subject to the limitations such as short-term followup and small sample size, there was a clinically important effect. The protocol of the present systematic review was registered in Open Science Framework (https://osf.io/ake85; registration doi: 10.17605/OSF.IO/AKE85).
C1 [Zeraattalab-Motlagh, Sheida; Shab-Bidar, Sakineh] Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Community Nutr, Tehran, Iran.
   [Jayedi, Ahmad] Semnan Univ Med Sci, Food Safety Res Ctr Salt, Semnan, Iran.
C3 Tehran University of Medical Sciences; Semnan University of Medical
   Sciences
RP Shab-Bidar, S (corresponding author), Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Community Nutr, Tehran, Iran.
EM s_shabbidar@tums.ac.ir
RI Shab-Bidar, Sakineh/H-9525-2017; Jayedi, Ahmad/E-7237-2017
OI jayedi, ahmad/0000-0003-4231-3147
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NR 82
TC 33
Z9 33
U1 1
U2 22
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0002-9165
EI 1938-3207
J9 AM J CLIN NUTR
JI Am. J. Clin. Nutr.
PD NOV
PY 2021
VL 114
IS 5
BP 1675
EP 1685
DI 10.1093/ajcn/nqab250
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA YC0LV
UT WOS:000739392700013
PM 34320173
OA Bronze
DA 2025-06-11
ER

PT J
AU Watson, KT
   Keller, J
   Spiro, CM
   Satz, IB
   Goncalves, S
   Pankow, H
   Chang, M
   Kosti, I
   Sequeira, A
   Bunney, WE
   Rasgon, NL
   Schatzberg, AF
   Lehallier, B
AF Watson, Kathleen T.
   Keller, Jennifer
   Spiro, Caleb M.
   Satz, Isaac B.
   Goncalves, Samantha, V
   Pankow, Heather
   Chang, Maureen
   Kosti, Idit
   Sequeira, Adolfo
   Bunney, William E.
   Rasgon, Natalie L.
   Schatzberg, Alan F.
   Lehallier, Benoit
TI Proteomic profiles of cytokines and chemokines in moderate to severe
   depression: Implications for comorbidities and biomarker discovery
SO BRAIN BEHAVIOR & IMMUNITY-HEALTH
LA English
DT Article
DE Proteomics; Major depressive disorder; Chemokines; Cytokines;
   Inflammation; Biomarkers
ID GLOBAL BURDEN; MORTALITY; DISORDER; OUTCOMES; DISEASE
AB Objective: This study assessed the proteomic profiles of cytokines and chemokines in individuals with moderate to severe depression, with or without comorbid medical disorders, compared to healthy controls. Two proteomic multiplex platforms were employed for this purpose. Metods: An immunofluorescent multiplex platform and an aptamer-based method were used to evaluate 32 protein analytes from 153 individuals with moderate to severe major depressive disorder (MDD) and healthy controls (HCs). The study focused on determining the level of agreement between the two platforms and evaluating the ability of individual analytes and principal components (PCs) to differentiate between the MDD and HC groups. Additionally, the study investigated the relationship between PCs consisting of chemokines and cytokines and comorbid inflammatory and cardiometabolic diseases. Findings: Analysis revealed a small or moderate correlation between 47% of the analytes measured by the two platforms. Two proteomic profiles were identified that differentiated individuals with moderate to severe MDD from HCs. High eotaxin, age, BMI, IP-10, or IL -10 characterized profile 1. This profile was associated with several cardiometabolic risk factors, including hypertension, hyperlipidemia, and type 2 diabetes. Profile 2 is characterized by higher age, BMI, interleukins, and a strong negative loading for eotaxin. This profile was associated with inflammation but not cardiometabolic risk factors. Conclusion: This study provides further evidence that proteomic profiles can be used to identify potential biomarkers and pathways associated with MDD and comorbidities. Our findings suggest that MDD is associated with distinct profiles of proteins that are also associated with cardiometabolic risk factors, inflammation, and obesity. In particular, the chemokines eotaxin and IP-10 appear to play a role in the relationship between MDD and cardiometabolic risk factors. These findings suggest that a focus on the interplay between MDD and comorbidities may be useful in identifying potential targets for intervention and improving overall health outcomes.
C1 [Watson, Kathleen T.; Keller, Jennifer; Spiro, Caleb M.; Satz, Isaac B.; Goncalves, Samantha, V; Pankow, Heather; Chang, Maureen; Rasgon, Natalie L.; Schatzberg, Alan F.] Stanford Sch Med, Dept Psychiat & Behav Hlth, Stanford, CA 94305 USA.
   [Kosti, Idit; Lehallier, Benoit] Alkahest Inc, San Carlos, CA USA.
   [Sequeira, Adolfo; Bunney, William E.] Univ Calif Irvine, Dept Psychiat & Human Behav, Irvine, CA USA.
   [Sequeira, Adolfo; Bunney, William E.] Sch Med, Irvine, CA USA.
C3 Stanford University; University of California System; University of
   California Irvine
RP Watson, KT (corresponding author), Stanford Sch Med, Dept Psychiat & Behav Hlth, Stanford, CA 94305 USA.
EM ktwatson@stanford.edu
FU Pritzker Neuropsychiatric Disorders Research Consortium; Alkahest Inc.
FX This study was supported by the Pritzker Neuropsychiatric Disorders
   Research Consortium and Alkahest Inc.
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NR 42
TC 0
Z9 0
U1 0
U2 1
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2666-3546
J9 BRAIN BEHAV IMMUN-HL
JI Brain Behav. Immun.-Health
PD MAR
PY 2024
VL 36
AR 100731
DI 10.1016/j.bbih.2024.100731
EA FEB 2024
PG 10
WC Immunology; Neurosciences; Psychiatry
WE Emerging Sources Citation Index (ESCI)
SC Immunology; Neurosciences & Neurology; Psychiatry
GA NT9G8
UT WOS:001202819100001
PM 38435722
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Hayes, JP
   Pierce, ME
   Valerio, KE
   Miller, MW
   Huber, BR
   Fortier, CB
   Fonda, JR
   Milberg, W
   McGlinchey, R
AF Hayes, Jasmeet P.
   Pierce, Meghan E.
   Valerio, Kate E.
   Miller, Mark W.
   Huber, Bertrand Russell
   Fortier, Catherine B.
   Fonda, Jennifer R.
   Milberg, William
   McGlinchey, Regina
TI The association between blast exposure and transdiagnostic health
   symptoms on systemic inflammation
SO NEUROPSYCHOPHARMACOLOGY
LA English
DT Article; Early Access
ID TRAUMATIC BRAIN-INJURY; QUALITY-OF-LIFE; POSTTRAUMATIC-STRESS-DISORDER;
   STRUCTURED CLINICAL INTERVIEW; GROWTH-HORMONE DEFICIENCY; MILITARY
   PERSONNEL; METABOLIC SYNDROME; OXIDATIVE STRESS; DSM-IV; OUTCOMES
AB Chronic elevation of systemic inflammation is observed in a wide range of disorders including PTSD, depression, and traumatic brain injury. Although previous work has demonstrated a link between inflammation and various diagnoses separately, few studies have examined transdiagnostic symptoms and inflammation within the same model. The objective of this study was to examine relationships between psychiatric and health variables and systemic inflammation and to determine whether mild traumatic brain injury (mTBI) and/or exposure to blast munitions moderate these relationships. Confirmatory factor analysis in a large sample (N = 357) of post-9/11 Veterans demonstrated a good fit to a four-factor model reflecting traumatic stress, affective, somatic, and metabolic latent variables. Hierarchical regression models revealed that each of the latent variables were associated with higher levels of systemic inflammation. However, the strongest relationship with inflammation emerged among those who had both war-zone blast exposures and metabolic dysregulation, even after adjusting for mental health latent variables. Exploratory analyses showed that blast exposure was associated with metabolic dysregulation in a dose-response manner, with self-reported closer blast proximity associated with the greatest metabolic dysregulation. Together, these results provide a greater understanding of the types of symptoms most strongly associated with inflammation and underscore the importance of maintaining a healthy lifestyle to reduce the impact of obesity and other metabolic symptoms on future chronic disease in younger to middle-aged Veterans.
C1 [Hayes, Jasmeet P.; Valerio, Kate E.] Ohio State Univ, Dept Psychol, Columbus, OH 43210 USA.
   [Hayes, Jasmeet P.; Valerio, Kate E.] Ohio State Univ, Chron Brain Injury Initiat, Columbus, OH 43210 USA.
   [Pierce, Meghan E.; Miller, Mark W.; Huber, Bertrand Russell; Fonda, Jennifer R.] Boston Univ, Sch Med, Dept Psychiat, Boston, MA 02118 USA.
   [Pierce, Meghan E.; Fortier, Catherine B.; Fonda, Jennifer R.; Milberg, William; McGlinchey, Regina] VA Boston Healthcare Syst, Translat Res Ctr TBI & Stress Disorders TRACTS, Boston, MA USA.
   [Miller, Mark W.; Huber, Bertrand Russell] VA Boston Healthcare Syst, Natl Ctr PTSD, Boston, MA USA.
   [Fortier, Catherine B.; Fonda, Jennifer R.; Milberg, William; McGlinchey, Regina] Harvard Med Sch, Dept Psychiat, Boston, MA 02115 USA.
C3 University System of Ohio; Ohio State University; University System of
   Ohio; Ohio State University; Boston University; Harvard University;
   Harvard University Medical Affiliates; US Department of Veterans
   Affairs; Veterans Health Administration (VHA); VA Boston Healthcare
   System; Harvard University; Harvard University Medical Affiliates; US
   Department of Veterans Affairs; Veterans Health Administration (VHA); VA
   Boston Healthcare System; Harvard University; Harvard Medical School
RP Hayes, JP (corresponding author), Ohio State Univ, Dept Psychol, Columbus, OH 43210 USA.; Hayes, JP (corresponding author), Ohio State Univ, Chron Brain Injury Initiat, Columbus, OH 43210 USA.
EM hayes.1075@osu.edu
RI Hayes, Jasmeet/AAN-4150-2020; McGlinchey, Regina/R-1971-2016; Fonda,
   Jennifer/ABG-2890-2021; Fortier, Catherine/AAS-2163-2021; Miller,
   Mark/G-7322-2011
OI Miller, Mark/0000-0001-6393-8563; Hayes, Jasmeet/0000-0002-5157-0666;
   Valerio, Kate/0000-0003-0361-502X; Fonda, Jennifer/0000-0001-9482-2918
FU National Institutes of Health (NIH), NIA grant [R01AG058822]; Department
   of Veterans Affairs by the Translational Research Center for TBI and
   Stress Disorders (TRACTS), a VA Rehabilitation Research and Development
   Traumatic Brain Injury Center of Excellence [B9254-C]
FX This work was supported by the National Institutes of Health (NIH), NIA
   grant number R01AG058822 to JPH. The content is solely the
   responsibility of the authors and does not necessarily represent the
   official views of the NIH. This research was also supported in part by
   the Department of Veterans Affairs by the Translational Research Center
   for TBI and Stress Disorders (TRACTS), a VA Rehabilitation Research and
   Development Traumatic Brain Injury Center of Excellence (B9254-C).
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NR 67
TC 5
Z9 6
U1 0
U2 5
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0893-133X
EI 1740-634X
J9 NEUROPSYCHOPHARMACOL
JI Neuropsychopharmacology
PD 2021 AUG 16
PY 2021
DI 10.1038/s41386-021-01138-8
EA AUG 2021
PG 8
WC Neurosciences; Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA UA8GQ
UT WOS:000685395300008
PM 34400776
OA Green Published, Bronze, Green Submitted
DA 2025-06-11
ER

PT J
AU Moazzami, K
   Lima, BB
   Sullivan, S
   Shah, A
   Bremner, JD
   Vaccarino, V
AF Moazzami, Kasra
   Lima, Bruno B.
   Sullivan, Samaah
   Shah, Amit
   Bremner, J. Douglas
   Vaccarino, Viola
TI Independent and Joint Association of Obesity and Metabolic Syndrome With
   Depression and Inflammation
SO HEALTH PSYCHOLOGY
LA English
DT Article
DE depression; metabolic syndrome; obesity; inflammation
ID INCIDENT CARDIOVASCULAR-DISEASE; PHYSICAL-ACTIVITY; HEALTHY OBESITY;
   SEX-DIFFERENCES; GLOBAL BURDEN; RISK; METAANALYSIS; DISORDER; HEART;
   PHQ-9
AB Objective: To investigate the separate and combined associations of obesity and metabolic syndrome (MetS) with depression and the role of inflammation. Method: Depression was assessed with the Patient Health Questionnaire-9 (PHQ-9) and was defined with a cutpoint of >= 10. Obesity was defined as body mass index (BMI) >= 30 kg/m2 from measured height and weight. MetS was defined based on the American Heart Association consensus definition. Participants were divided into four groups: healthy normal weight (MHN), metabolically healthy obese (MHO), metabolically unhealthy normal weight (MUN), and metabolic unhealthy obese (MUO). C-Reactive protein was assessed in a subsample. Results: A total of 18,025 subjects were included in the analysis. Participants with MUO had the highest prevalence of depression compared with the MHN group (14.8% vs. 6.8, p <.001). While both obesity and MetS were independently associated with depression, there was a significant interaction between the two (p <.001), indicating that the associations of obesity and MetS with depression were synergistic. After adjusting for baseline characteristics, compared with the MHN group, the MUO group had the highest odds of depression (odds ratio [OR] = 2.30, 95% CI [2.03, 2.61]), followed by MHO group (OR = 1.51, 95% CI [1.30, 1.74]) and the MUN group (OR = 1.39, 95% CI [1.18, 1.64]). The MUO group also showed the highest level of C-reactive protein, and the latter partially mediated the effect between MUO and depressive symptoms (20.5% of the total effect). Conclusion: Both obesity and MetS are associated with depression independent of each other, but when present together, these conditions have a synergistic association with depression.
C1 [Moazzami, Kasra; Lima, Bruno B.; Sullivan, Samaah; Shah, Amit; Vaccarino, Viola] Emory Univ, Dept Epidemiol, Rollins Sch Publ Hlth, 1518 Clifton Rd North East, Atlanta, GA 30322 USA.
   [Moazzami, Kasra; Lima, Bruno B.; Shah, Amit; Vaccarino, Viola] Emory Univ, Sch Med, Dept Med, Div Cardiol, Atlanta, GA USA.
   [Shah, Amit; Bremner, J. Douglas] Atlanta Vet Affairs Med Ctr, Decatur, GA USA.
   [Bremner, J. Douglas] Emory Univ, Sch Med, Dept Psychiat & Behav Sci, Atlanta, GA USA.
   [Bremner, J. Douglas] Emory Univ, Sch Med, Dept Radiol, Atlanta, GA 30322 USA.
C3 Emory University; Rollins School Public Health; Emory University; US
   Department of Veterans Affairs; Veterans Health Administration (VHA);
   Atlanta VA Health Care System; Emory University; Emory University
RP Vaccarino, V (corresponding author), Emory Univ, Dept Epidemiol, Rollins Sch Publ Hlth, 1518 Clifton Rd North East, Atlanta, GA 30322 USA.
EM viola.vaccarino@emory.edu
RI Bremner, James/B-1632-2013; Lima, Bruno/AAB-2807-2021; Vaccarino,
   Viola/AAW-5600-2020
OI Vaccarino, Laura Viola/0000-0002-9054-0654; Shah,
   Amit/0000-0001-9099-9687
FU National Institutes of Health [R01 HL125246, R01 HL136205, K23 HL127251,
   K12HD085850, T32 HL130025]
FX This work was supported by the National Institutes of Health through the
   following grants: R01 HL125246, R01 HL136205, K23 HL127251, K12HD085850,
   and T32 HL130025. All authors report no conflicts of interest. The
   sponsors of this study had no role in the design and conduct of the
   study; collection, management, analysis, and interpretation of the data;
   and preparation, review, or approval of the manuscript.
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NR 52
TC 34
Z9 40
U1 1
U2 18
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 0278-6133
EI 1930-7810
J9 HEALTH PSYCHOL
JI Health Psychol.
PD JUL
PY 2019
VL 38
IS 7
BP 586
EP 595
DI 10.1037/hea0000764
PG 10
WC Psychology, Clinical; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology
GA IE2NI
UT WOS:000472220600003
PM 31120270
OA Green Accepted, hybrid
DA 2025-06-11
ER

PT J
AU Kelly, DL
   Gorelick, DA
   Conley, RR
   Boggs, DL
   Linthicum, J
   Liu, F
   Feldman, S
   Ball, MP
   Wehring, HJ
   McMahon, RP
   Huestis, MA
   Heishman, SJ
   Warren, KR
   Buchanan, RW
AF Kelly, Deanna L.
   Gorelick, David A.
   Conley, Robert R.
   Boggs, Douglas L.
   Linthicum, Jared
   Liu, Fang
   Feldman, Stephanie
   Ball, M. Patricia
   Wehring, Heidi J.
   McMahon, Robert P.
   Huestis, Marilyn A.
   Heishman, Stephen J.
   Warren, Kimberly R.
   Buchanan, Robert W.
TI Effects of the Cannabinoid-1 Receptor Antagonist Rimonabant on
   Psychiatric Symptoms in Overweight People With Schizophrenia A
   Randomized, Double-Blind, Pilot Study
SO JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
LA English
DT Article
DE rimonabant; schizophrenia; obesity; metabolic syndrome; depression
ID ENDOCANNABINOID SYSTEM; METABOLIC SYNDROME; OBESITY; PREVALENCE; DRUG;
   EFFICACY; ANXIETY; TRIALS
AB Weight gain is a major adverse effect of several second-generation antipsychotic medications. Rimonabant is a cannabinoid-1 receptor antagonist that promotes weight loss in the general population. We conducted a 16-week, double-blind, placebo-controlled study of rimonabant (20 mg/d) in people with schizophrenia or schizo-affective disorder, based on the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition criteria, who were clinically stable on second-generation antipsychotics. Participants had a body mass index of 27 kg/m(2) or higher with hyperlipidemia or body mass index of 30 kg/m2 or higher, and no current substance abuse/dependence (except nicotine), more than weekly cannabis use, or recent depressive symptoms/suicidality. An exercise and dietary counseling group was offered weekly. Target enrollment was 60; the trial was terminated early because of withdrawal of rimonabant from the European market. Fifteen participants were randomized (7 rimonabant, 8 placebo); 5 completed in each group. Rimonabant was associated with a greater reduction in Brief Psychiatric Rating Scale total score versus placebo (mean T SE difference, -1.9 +/- 0.8, P = 0.02), driven by differences in the Brief Psychiatric Rating Scale anxiety/depression (-1.4 +/- 0.35, P = 0.0004) and hostility (-0.7 +/- 0.3, P = 0.02) factors. Group differences were not significant for the Calgary Depression Scale total score (P = 0.24), Scale for the Assessment of Negative Symptoms total score (P = 0.13), weight, blood pressure, or fasting lipids or glucose. Rimonabant was well tolerated with no significant adverse events. No significant weight loss, metabolic effects, or adverse psychiatric effects were associated with the cannabinoid-1 receptor antagonist rimonabant in this small sample of people with schizophrenia. The endocannabinoid system remains a promising target for pharmacotherapy of schizophrenia and obesity.
C1 [Kelly, Deanna L.; Boggs, Douglas L.; Linthicum, Jared; Liu, Fang; Feldman, Stephanie; Ball, M. Patricia; Wehring, Heidi J.; McMahon, Robert P.; Warren, Kimberly R.; Buchanan, Robert W.] Univ Maryland, Sch Med, Maryland Psychiat Res Ctr, Baltimore, MD 21228 USA.
   [Gorelick, David A.; Huestis, Marilyn A.; Heishman, Stephen J.] Natl Inst Drug Abuse, Intramural Res Program, NIH, Bethesda, MD USA.
   [Conley, Robert R.] Eli Lilly & Co, Indianapolis, IN 46285 USA.
C3 University System of Maryland; University of Maryland Baltimore;
   National Institutes of Health (NIH) - USA; NIH National Institute on
   Drug Abuse (NIDA); Eli Lilly
RP Kelly, DL (corresponding author), Univ Maryland, Sch Med, Maryland Psychiat Res Ctr, POB 21247, Baltimore, MD 21228 USA.
EM dkelly@mprc.umaryland.edu
RI Gorelick, David/ABF-4941-2021; Liu, Fangyang/E-9901-2013; Boggs,
   Douglas/F-5429-2010; McMahon, Robert/C-5462-2009
FU National Institutes of Mental Health (NIMH) [R34 MH 077839, P30 068580];
   NIDA Residential Research Support Services [HSN271200599091CADB];
   Sanofi-Aventis; National Institute on Drug Abuse (NIDA)
FX This study was supported by the National Institutes of Mental Health
   (NIMH) grants R34 MH 077839 (PI Buchanan) and P30 068580 (PI Buchanan),
   the Intramural Research Program, National Institute on Drug Abuse
   (NIDA), and NIDA Residential Research Support Services Contract
   HSN271200599091CADB (PI Kelly). Deanna L. Kelly, David Gorelick, Douglas
   L. Boggs, Robert P. McMahon, Jared Linthicum, Fang Liu, Stephanie
   Feldman, M. Patricia Ball, Heidi J. Wehring, Stephen J. Heishman, and
   Kimberly Warren have no competing interests or financial support to
   disclose. Robert R. Conley is a full-time employee and stockholder of
   Eli Lilly & Co. Marilyn A. Huestis has a cooperative research and
   development agreement with Sanofi-Aventis. Robert W. Buchanan is a
   member of the data and safety monitoring board of Cephalon, Otsuka,
   Pfizer, and Wyeth; a consultant for Abbott, GlaxoSmithKline, Merck,
   Organon, Sanofi-Aventis, Solvay, and Wyeth; and a member of the advisory
   board of AstraZeneca, Pfizer, and Roche.
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NR 45
TC 44
Z9 50
U1 0
U2 14
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0271-0749
EI 1533-712X
J9 J CLIN PSYCHOPHARM
JI J. Clin. Psychopharmacol.
PD FEB
PY 2011
VL 31
IS 1
BP 86
EP 91
DI 10.1097/JCP.0b013e318204825b
PG 6
WC Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Psychiatry
GA 700UY
UT WOS:000285771000015
PM 21192149
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Barnes, TRE
   Bhatti, SF
   Adroer, R
   Paton, C
AF Barnes, T. R. E.
   Bhatti, S. F.
   Adroer, R.
   Paton, C.
TI Screening for the metabolic side effects of antipsychotic medication:
   findings of a 6-year quality improvement programme in the UK
SO BMJ OPEN
LA English
DT Article
DE AUDIT
ID SCHIZOPHRENIA; MORTALITY; ARIPIPRAZOLE; METAANALYSIS
AB Objectives To increase the frequency and quality of screening for the metabolic syndrome in people prescribed continuing antipsychotic medication.
   Design An audit-based, quality improvement programme (QIP) with customised feedback to participating mental health services after each audit, including benchmarked data on their relative and absolute performance against an evidence-based practice standard and the provision of bespoke change interventions.
   Setting Adult, assertive outreach, community psychiatric services in the UK.
   Participants 6 audits were conducted between 2006 and 2012. 21 mental health Trusts participated in the baseline audit in 2006, submitting data on screening for 1966 patients, while 32 Trusts participated in the 2012 audit, submitting data on 1591 patients.
   Results Over the 6years of the programme, there was a statistically significant increase in the proportion of patients for whom measures for all 4 aspects of the metabolic syndrome had been documented in the clinical records in the previous year, from just over 1 in 10 patients in 2006 to just over 1 in 3 by 2012. The proportion of patients with no evidence of any screening fell from almost 1/2 to 1 in 7 patients over the same period.
   Conclusions The findings suggest that audit-based QIPs can help improve clinical practice in relation to physical healthcare screening. Nevertheless, they also reveal that only a minority of community psychiatric patients prescribed antipsychotic medication is screened for the metabolic syndrome in accordance with best practice recommendations, and therefore potentially remediable causes of poor physical health remain undetected and untreated.
C1 [Barnes, T. R. E.; Paton, C.] Univ London Imperial Coll Sci Technol & Med, Ctr Mental Hlth, London, England.
   [Barnes, T. R. E.; Bhatti, S. F.; Adroer, R.; Paton, C.] Royal Coll Psychiatrists, Prescribing Observ Mental Hlth POMH UK, London SW1X 8PG, England.
C3 Imperial College London
RP Barnes, TRE (corresponding author), Univ London Imperial Coll Sci Technol & Med, Ctr Mental Hlth, Hammersmith Hosp Campus, London, England.
EM t.r.barnes@imperial.ac.uk
RI Barnes, Thomas/KJC-1245-2024
FU Health Foundation, under its 'Engaging with Quality' initiative; mental
   health NHS Trusts
FX POMH-UK was originally funded by a tapering grant from an independent
   charity, the Health Foundation, under its 'Engaging with Quality'
   initiative. It is now funded entirely from the subscriptions of member
   mental health services, principally mental health NHS Trusts.
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NR 33
TC 40
Z9 43
U1 1
U2 8
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2044-6055
J9 BMJ OPEN
JI BMJ Open
PY 2015
VL 5
IS 10
AR e007633
DI 10.1136/bmjopen-2015-007633
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA CX1PH
UT WOS:000365467600014
PM 26428329
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Li, CY
   Ostermann, T
   Hardt, M
   Lüdtke, R
   Broecker-Preuss, M
   Dobos, G
   Michalsen, A
AF Li, Chenying
   Ostermann, Thomas
   Hardt, Monika
   Luedtke, Rainer
   Broecker-Preuss, Martina
   Dobos, Gustav
   Michalsen, Andreas
TI Metabolic and Psychological Response to 7-Day Fasting in Obese Patients
   with and without Metabolic Syndrome
SO FORSCHENDE KOMPLEMENTARMEDIZIN
LA English
DT Article
DE Adipokines; Caloric restriction; Fasting; Metabolic syndrome; Mood
ID LOW-CALORIE DIET; ATRIAL-NATRIURETIC-PEPTIDE; WEIGHT-LOSS;
   RHEUMATOID-ARTHRITIS; RANDOMIZED-TRIAL; VEGETARIAN DIET; RESTRICTION;
   REDUCTION; LEPTIN; HYPERTENSIVES
AB Background: Extended modified fasting is a frequently practiced tradition in Europe. It is claimed to improve the cardiometabolic state and physical and psychological well-being by an evolutionary co-developed adaptation response. We aimed to investigate the cardiometabolic and psychological effects of a 7-day fast and differences of these responses between patients with or without metabolic syndrome (MetS). Methods: We investigated 30 female subjects (49.0 +/- 8.1 years, BMI 30.4 +/- 6.7 kg/m(2)) with (n = 12) and without (n = 18) MetS. All subjects participated in a 7-day fast according to Buchinger with a nutritional energy intake of 300 kcal/day and stepwise reintroduction of solid food thereafter. Outcomes were assessed baseline and after fasting and included measures of metabolic and glucoregulatory control, adipokines as well as psychological well-being as assessed by Profile of Mood States (POMS) and Hospital Anxiety and Depression Scale (HADS). Results: Mean weight decreased from 85.4 +/- 18.8 kg to 79.7 +/- 18.2 kg accompanied by systolic/diastolic blood pressure (BP) reduction of -16.2 mm Hg (95% CI: -9.1; -23.3 mm Hg) and -6.0 mm Hg (95% CI: -1.8; -10.3 mm Hg), each p < 0.001 and p = 0.005. Fasting led to marked decreases of levels of LDL-cholesterol, leptin, and insulin and increases of levels of adiponectin, leptin receptors, and resistin. Fasting-induced mood enhancement was reflected by decreased anxiety, depression, fatigue, and improved vigor. Patients with MetS showed some greater changes in BP, LDL-cholesterol, triglycerides, adiponectin, leptin, and sleep quality. Fasting was well-tolerated. Conclusions: Our results point to marked beneficial responses to 7-day modified fasting and a potential role in the prevention of the MetS. Randomized trials with longer observation periods should test the clinical effectiveness of fasting in metabolic diseases.
C1 [Li, Chenying] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Tradit Chinese Med, Guangzhou 510275, Guangdong, Peoples R China.
   [Li, Chenying; Michalsen, Andreas] Charite, Inst Social Med Epidemiol & Hlth Econ, D-13353 Berlin, Germany.
   [Ostermann, Thomas] Univ Witten Herdecke, Ctr Integrat Med, Herdecke, Germany.
   [Hardt, Monika; Dobos, Gustav] Univ Duisburg Essen, Kliniken Essen Mitte, Fac Med, Dept Complementary & Integrat Med, Duisburg, Germany.
   [Luedtke, Rainer] Karl & Veron Carstens Fdn, Essen, Germany.
   [Broecker-Preuss, Martina] Univ Duisburg Essen, Univ Hosp Essen, Dept Endocrinol, Duisburg, Germany.
   [Broecker-Preuss, Martina] Univ Duisburg Essen, Univ Hosp Essen, Div Lab Res, Duisburg, Germany.
   [Michalsen, Andreas] Immanuel Hosp Berlin, Dept Internal & Complementary Med, Berlin, Germany.
C3 Sun Yat Sen University; Berlin Institute of Health; Free University of
   Berlin; Humboldt University of Berlin; Charite Universitatsmedizin
   Berlin; Witten Herdecke University; University of Duisburg Essen;
   Kliniken Essen-Mitte; University of Duisburg Essen; University of
   Duisburg Essen
RP Michalsen, A (corresponding author), Immanuel Krankenhaus Berlin, Zentrum Naturheilkunde, Am Kleinen Wannsee 5, D-14106 Berlin, Germany.
EM a.michalsen@immanuel.de
RI Bröcker-Preuß, Martina/KPB-0300-2024; Ostermann, Thomas/LSK-7444-2024
OI Ipekoglu, Berk/0000-0002-6093-5014; Ostermann,
   Thomas/0000-0003-2695-0701
FU Karl and Veronica Carstens Foundation, Essen, Germany
FX The study was funded by a grant from the Karl and Veronica Carstens
   Foundation, Essen, Germany. All authors have no competing interest.
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NR 44
TC 38
Z9 44
U1 0
U2 14
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1661-4119
EI 1661-4127
J9 FORSCH KOMPLEMENTMED
JI Forsch. Komplement.med.
PY 2013
VL 20
IS 6
BP 413
EP 420
DI 10.1159/000353672
PG 8
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Integrative & Complementary Medicine
GA 296NT
UT WOS:000330192500002
PM 24434755
OA hybrid
DA 2025-06-11
ER

PT J
AU Chan, KL
   Poller, WC
   Swirski, FK
   Russo, SJ
AF Chan, Kenny L.
   Poller, Wolfram C.
   Swirski, Filip K.
   Russo, Scott J.
TI Central regulation of stress-evoked peripheral immune responses
SO NATURE REVIEWS NEUROSCIENCE
LA English
DT Review
ID C-FOS EXPRESSION; INFLAMMATORY-BOWEL-DISEASE; AUTONOMIC NERVOUS-SYSTEM;
   MAJOR DEPRESSIVE DISORDER; INNATE LYMPHOID-CELLS; ADIPOSE-TISSUE; SOCIAL
   DEFEAT; BONE-MARROW; T-CELLS; CIRCULATING LEVELS
AB Stress-linked psychiatric disorders, including anxiety and major depressive disorder, are associated with systemic inflammation. Recent studies have reported stress-induced alterations in haematopoiesis that result in monocytosis, neutrophilia, lymphocytopenia and, consequently, in the upregulation of pro-inflammatory processes in immunologically relevant peripheral tissues. There is now evidence that this peripheral inflammation contributes to the development of psychiatric symptoms as well as to common co-morbidities of psychiatric disorders such as metabolic syndrome and immunosuppression. Here, we review the specific brain and spinal regions, and the neuronal populations within them, that respond to stress and transmit signals to peripheral tissues via the autonomic nervous system or neuroendocrine pathways to influence immunological function. We comprehensively summarize studies that have employed retrograde tracing to define neurocircuits linking the brain to the bone marrow, spleen, gut, adipose tissue and liver. Moreover, we highlight studies that have used chemogenetic or optogenetic manipulation or intracerebroventricular administration of peptide hormones to control somatic immune responses. Collectively, this growing body of literature illustrates potential mechanisms through which stress signals are conveyed from the CNS to immune cells to regulate stress-relevant behaviours and comorbid pathophysiology.
   Stress modulates immune system function and systemic inflammation is linked to stress-related disorders, including depression. Russo and colleagues outline the neural circuits through which the CNS regulates immune cell function in peripheral tissues in response to stress and consider how these responses contribute to stress-related pathophysiology.
C1 [Chan, Kenny L.; Russo, Scott J.] Icahn Sch Med Mt Sinai, Friedman Brain Inst, Nash Family Dept Neurosci, New York, NY 10029 USA.
   [Chan, Kenny L.; Poller, Wolfram C.; Swirski, Filip K.; Russo, Scott J.] Icahn Sch Med Mt Sinai, Brain & Body Res Ctr, New York, NY 10029 USA.
   [Poller, Wolfram C.; Swirski, Filip K.] Icahn Sch Med Mt Sinai, Cardiovasc Res Inst, New York, NY USA.
C3 Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at
   Mount Sinai; Icahn School of Medicine at Mount Sinai
RP Chan, KL; Russo, SJ (corresponding author), Icahn Sch Med Mt Sinai, Friedman Brain Inst, Nash Family Dept Neurosci, New York, NY 10029 USA.; Chan, KL; Russo, SJ (corresponding author), Icahn Sch Med Mt Sinai, Brain & Body Res Ctr, New York, NY 10029 USA.
EM kenny.chan@mssm.edu; scott.russo@mssm.edu
RI Russo, Scott/R-7107-2019; Swirski, Filip/AAF-1340-2019
OI Poller, Wolfram/0000-0002-4632-5551; Swirski, Filip/0000-0002-3163-9152
FU Canadian Institutes of Health Research [K99DK137037]; NARSAD Young
   Investigator Award from the Brain and Behaviour Research Foundation
   [R35HL135752]; National Institute of Diabetes and Digestive and Kidney
   Diseases of the National Institutes of Health [P01HL131478,
   1P01HL142494, R01MH104559, R01MH127820]; Cure Alzheimer's Fund; 
   [201811MFE-414896-231226]
FX We thank all authors who contributed to the work collected and
   summarized in this Review. This Review was supported by a Postdoctoral
   Fellowship from the Canadian Institutes of Health Research
   (201811MFE-414896-231226), a NARSAD Young Investigator Award from the
   Brain and Behaviour Research Foundation (30894), and a Pathway to
   Independence Award from the National Institute of Diabetes and Digestive
   and Kidney Diseases of the National Institutes of Health (K99DK137037)
   to K.L.C., a research grant from the Cure Alzheimer's Fund to W.C.P.,
   National Institutes of Health grants R35HL135752, P01HL131478 and
   1P01HL142494 to F.K.S., and R01MH104559 and R01MH127820 to S.J.R. The
   content is solely the responsibility of the authors and does not
   necessarily represent the official views of the National Institutes of
   Health.
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NR 208
TC 70
Z9 72
U1 19
U2 72
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 1471-003X
EI 1471-0048
J9 NAT REV NEUROSCI
JI Nat. Rev. Neurosci.
PD OCT
PY 2023
VL 24
IS 10
BP 591
EP 604
DI 10.1038/s41583-023-00729-2
EA AUG 2023
PG 14
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA S1XQ5
UT WOS:001060216100002
PM 37626176
OA Green Accepted
HC Y
HP N
DA 2025-06-11
ER

PT J
AU García, JB
   Rentero, PZ
   Cánovas, JM
   Jara, PG
   Hernández, ML
   Alemán, JA
AF Bernabe Garcia, Juana
   Zafrilla Rentero, Pilar
   Mulero Canovas, Juana
   Gomez Jara, Purificacion
   Leal Hernandez, Mariano
   Abellan Aleman, Jose
TI Biochemical and nutritional markers and antioxidant activity in
   metabolic syndrome
SO ENDOCRINOLOGIA Y NUTRICION
LA English
DT Article
DE Metabolic syndrome; Antioxidant; Nutrition; Isoprostanes
ID CARDIOVASCULAR RISK-FACTORS; CORONARY-HEART-DISEASE; PREVALENCE;
   COMPONENTS; WOMEN
AB Background and objectives: (1) Nutritional assessment of the diet followed by patients with metabolic syndrome and (2) biochemical analysis of the oxidation-reduction level in patients with metabolic syndrome.
   Materials and methods: A cross-sectional study was conducted in patients with metabolic syndrome in Murcia. Fifty-three patients, 33 with and 20 without (control group) metabolic syndrome, were selected. The intervention consisted of completion of a recall survey and a test to nutritionally assess dietary intake. Anthropometric and laboratory variables, including those related to antioxidant activity, were also tested.
   Results: Antioxidant activity was within normal limits in both groups (1.7 +/- 0.2 mmol/L in the control group and 1.8 +/- 0.1 mmol/L in the metabolic syndrome group) (NS). Superoxide dismutase levels were not significantly different between the groups. Mean glutathione reductase levels (U/L) were higher in the control group when compared to patients with metabolic syndrome (p<0.05). With regard to oxidative stress biomarkers, mean isoprostane levels were higher in the control group (4.9 +/- 6.2 ng/mL) than in the metabolic syndrome patients (3.5 +/- 3.9 ng/mL) (p<0.05). Oxidized LDL values tended to be higher in metabolic syndrome patients (96 +/- 23.2 U/L) when compared to the control group (86.2 +/- 17.3 U/L), but differences were not significant.
   Conclusions: There is a trend to a poorer nutritional and biochemical profile in patients with metabolic syndrome, who also tend to have a greater degree of oxidative stress. (C) 2013 SEEN. Published by Elsevier Espana, S.L. All rights reserved.
C1 [Bernabe Garcia, Juana; Zafrilla Rentero, Pilar; Mulero Canovas, Juana; Gomez Jara, Purificacion; Leal Hernandez, Mariano; Abellan Aleman, Jose] Univ Catolica Murcia, Catedra Riesgo Cardiovasc, Murcia, Spain.
C3 Universidad Catolica de Murcia
RP Alemán, JA (corresponding author), Univ Catolica Murcia, Catedra Riesgo Cardiovasc, Murcia, Spain.
EM jabellan@pdi.ucam.edu
RI Zafrilla, Pilar/JAN-5983-2023
OI ZAFRILLA, PILAR/0000-0002-1463-7120; Leal Hernandez,
   Mariano/0000-0001-8193-6457
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NR 29
TC 7
Z9 7
U1 1
U2 4
PU ELSEVIER ESPANA SLU
PI BARCELONA
PA AV JOSEP TARRADELLAS, 20-30, 1ERA PLANTA, BARCELONA, CP-08029, SPAIN
SN 1575-0922
EI 1579-2021
J9 ENDOCRINOL NUTR
JI Endocrinol. Nutr.
PD JUN-JUL
PY 2014
VL 61
IS 6
BP 302
EP 308
PG 7
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA V43VR
UT WOS:000209709400002
PM 24560484
DA 2025-06-11
ER

PT J
AU Aldini, G
   Orioli, M
   Rossoni, G
   Savi, F
   Braidotti, P
   Vistoli, G
   Yeum, KJ
   Negrisoli, G
   Carini, M
AF Aldini, Giancarlo
   Orioli, Marica
   Rossoni, Giuseppe
   Savi, Federica
   Braidotti, Paola
   Vistoli, Giulio
   Yeum, Kyung-Jin
   Negrisoli, Gianpaolo
   Carini, Marina
TI The carbonyl scavenger carnosine ameliorates dyslipidaemia and renal
   function in Zucker obese rats
SO JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
LA English
DT Article
DE carnosine; L and D enantiomers; carbonyl quenching activity; metabolic
   syndrome; obese Zucker rats; chronic treatment; renoprotection
ID HISTIDINE-CONTAINING PEPTIDES; TANDEM MASS-SPECTROMETRY; METABOLIC
   SYNDROME-X; LIPID-PEROXIDATION; OXIDATIVE STRESS; PROTEIN CARBONYLATION;
   SPECTROPHOTOMETRIC METHOD; CELLULAR DYSFUNCTION; MEDIATED INHIBITION;
   SYMPATHETIC-NERVE
AB The metabolic syndrome is a risk factor that increases the risk for development of renal and vascular complications. This study addresses the effects of chronic administration of the endogenous dipeptide carnosine (beta-alanyl-L-histidine, L-CAR) and of its enantiomer (beta-alanyl-D-histidine, D-CAR) on hyperlipidaemia, hypertension, advanced glycation end products, advanced lipoxidation end products formation and development of nephropathy in the non-diabetic, Zucker obese rat. The Zucker rats received a daily dose of L-CAR or D-CAR (30 mg/kg in drinking water) for 24 weeks. Systolic blood pressure was recorded monthly. At the end of the treatment, plasma levels of triglycerides, total cholesterol, glucose, insulin, creatinine and urinary levels of total protein, albumin and creatinine were measured. Several indices of oxidative/carbonyl stress were also measured in plasma, urine and renal tissue. We found that both L- and D-CAR greatly reduced obese-related diseases in obese Zucker rat, by significantly restraining the development of dyslipidaemia, hypertension and renal injury, as demonstrated by both urinary parameters and electron microscopy examinations of renal tissue. Because the protective effect elicited by L- and D-CAR was almost superimposable, we conclude that the pharmacological action of L-CAR is not due to a pro-histaminic effect (D-CAR is not a precursor of histidine, since it is stable to peptidic hydrolysis), and prompted us to propose that some of the biological effects can be mediated by a direct carbonyl quenching mechanism.
C1 [Aldini, Giancarlo; Orioli, Marica; Vistoli, Giulio; Carini, Marina] Univ Milan, Dept Pharmaceut Sci Pietro Pratesi, I-20133 Milan, Italy.
   [Rossoni, Giuseppe] Univ Milan, Dept Pharmacol Chemotherapy & Med Toxicol, I-20133 Milan, Italy.
   [Savi, Federica; Braidotti, Paola] San Paolo Hosp, Dept Med Surg & Odontol, Milan, Italy.
   [Savi, Federica; Braidotti, Paola] Univ Milan, IRCCS Fdn Policlin, I-20133 Milan, Italy.
   [Yeum, Kyung-Jin] Tufts Univ, Jean Mayer USDA Human Nutr Res Ctr Aging, Boston, MA 02111 USA.
   [Negrisoli, Gianpaolo] Flamma SpA, Chignolo Disol, Prov Bergamo, Italy.
C3 University of Milan; University of Milan; San Paolo-Polo Universitaria
   Hospital; University of Milan; Tufts University; United States
   Department of Agriculture (USDA)
RP Aldini, G (corresponding author), Univ Milan, Dept Pharmaceut Sci Pietro Pratesi, Via Mangiagalli 25, I-20133 Milan, Italy.
EM giancarlo.aldini@unimi.it
RI aldini, giancarlo/C-3533-2013; CARINI, MARINA/D-3084-2015; orioli,
   marica/F-7606-2015
OI CARINI, MARINA/0000-0003-3407-5425; orioli, marica/0000-0003-1558-9551;
   Vistoli, Giulio/0000-0002-3939-5172; aldini,
   giancarlo/0000-0002-2355-6744; Yeum, Kyung-Jin/0000-0002-7846-0272
FU University of Milan; Regione Lombardia-MIUR [L.297 - Art. 12/BioTech
   DM27909]
FX This work was supported by funds from the University of Milan (PUR 2007,
   2008) MIUR (PRIN 2007) and from Regione Lombardia-MIUR (L.297 - Art.
   12/BioTech DM27909). The authors are grateful to Jaclyn Michelle Winkel
   for English language corrections.
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NR 73
TC 160
Z9 171
U1 0
U2 13
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
EI 1582-4934
J9 J CELL MOL MED
JI J. Cell. Mol. Med.
PD JUN
PY 2011
VL 15
IS 6
BP 1339
EP 1354
DI 10.1111/j.1582-4934.2010.01101.x
PG 16
WC Cell Biology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Research & Experimental Medicine
GA 769ZX
UT WOS:000291057900010
PM 20518851
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Gambino, G
   Frinchi, M
   Giglia, G
   Scordino, M
   Urone, G
   Ferraro, G
   Mud, G
   Sardo, P
   Di Majo, D
   Di Liberto, V
AF Gambino, Giuditta
   Frinchi, Monica
   Giglia, Giuseppe
   Scordino, Miriana
   Urone, Giulia
   Ferraro, Giuseppe
   Mud, Giuseppa
   Sardo, Pierangelo
   Di Majo, Danila
   Di Liberto, Valentina
TI Impact of "Golden" tomato juice on cognitive alterations in metabolic
   syndrome: Insights into behavioural and biochemical changes in a
   high-fat diet rat model
SO JOURNAL OF FUNCTIONAL FOODS
LA English
DT Article
DE Nutraceutical; Cognitive impairment; Behaviour; Neuroinflammation;
   PI3K/Akt; MAPK/ERK
ID OXIDATIVE STRESS; MEMORY; IMPAIRMENT; LYCOPENE; OBESITY; HIPPOCAMPUS;
   NARINGENIN; NEUROINFLAMMATION; NEUROGENESIS; MECHANISMS
AB "Golden" tomato (GT) plays a protective role in metabolic dysfunction induced by High-Fat Diet (HFD). Our aim is to characterize the phytonutrient composition of the juice and explore the influence of GT, orally administered for one month, on cognitive impairment associated with Metabolic Syndrome (MetS) in male rats. We investigated reactivity, stress response and memory, together with brain neurotrophic/inflammatory signaling. Our data showed that HFD-induced functional modifications were ameliorated by GT nutritional supplementation. In particular, the behavioural reactivity improved in HFD/GT rats, that also showed a better performance in tests measuring anxiety and anhedonia. Furthermore, GT consumption rescued the declarative memory impairment. Lastly, GT supplementation counteracted HFD-induced brain alterations in PI3K\Akt and MAPK/ERK signalling pathways. In conclusion, this study provides evidence of the importance of food supplementation with GT in the protection from neuroinflammation and cognitive alterations associated with MetS.
C1 [Gambino, Giuditta; Frinchi, Monica; Giglia, Giuseppe; Scordino, Miriana; Urone, Giulia; Ferraro, Giuseppe; Mud, Giuseppa; Sardo, Pierangelo; Di Majo, Danila; Di Liberto, Valentina] Univ Palermo, Dept Biomed Neurosci & Adv Diagnost BIND, Corso Tukory 129, I-90127 Palermo, Italy.
   [Giglia, Giuseppe; Ferraro, Giuseppe; Sardo, Pierangelo; Di Majo, Danila] Univ Palermo, Postgrad Sch Nutr, Palermo, Italy.
C3 University of Palermo; University of Palermo
RP Gambino, G (corresponding author), Univ Palermo, Dept Biomed Neurosci & Adv Diagnost BIND, Corso Tukory 129, I-90127 Palermo, Italy.
EM giuditta.gambino@unipa.it
RI Di+Liberto, Valentina/ACL-0264-2022; Mudò, Giuseppa/G-7408-2011; Di
   Majo, Danila/A-9078-2015; Giglia, Giuseppe/M-7100-2016
OI Frinchi, Monica/0000-0002-1061-5725; Urone, Giulia/0009-0000-3130-2202;
   Gambino, Giuditta/0000-0001-8155-2808; Giglia,
   Giuseppe/0000-0001-5616-3595; Mudo', Giuseppa/0000-0002-3275-9981;
   SARDO, Pierangelo/0000-0002-4997-3263; Scordino,
   Miriana/0000-0003-4224-5869
FU Project IN.PO.S.A - PSR Sicilia (2014-2020)-16.1 [G66D20000170009];
   Funds "MUR PNR D.M. 737/2021" [PRJ-1002]
FX This work was partly supported by the project IN.PO.S.A-Grant Number:
   G66D20000170009, funded by PSR Sicilia (2014-2020)-16.1 and partly with
   PRJ-1002 Funds provided by funds "MUR PNR D.M. 737/2021" to Prof.
   Giuseppe Giglia.
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NR 96
TC 5
Z9 5
U1 0
U2 1
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1756-4646
EI 2214-9414
J9 J FUNCT FOODS
JI J. Funct. Food.
PD JAN
PY 2024
VL 112
AR 105964
DI 10.1016/j.jff.2023.105964
EA DEC 2023
PG 12
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA GA5T8
UT WOS:001149958000001
OA gold
DA 2025-06-11
ER

PT J
AU Tadic, M
   Ivanovic, B
   Cuspidi, C
AF Tadic, Marijana
   Ivanovic, Branislava
   Cuspidi, Cesare
TI What Do We Currently Know About Metabolic Syndrome and Atrial
   Fibrillation?
SO CLINICAL CARDIOLOGY
LA English
DT Review
ID LEFT-VENTRICULAR HYPERTROPHY; MIDDLE-AGED MEN; DIABETES-MELLITUS;
   ATHEROSCLEROSIS RISK; BLOOD-PRESSURE; FOLLOW-UP; INDEPENDENT RISK; PULSE
   PRESSURE; HEART-DISEASE; OBESITY
AB Metabolic syndrome represents a cluster of atherogenic risk factors including hypertension, insulin resistance, obesity, and dyslipidemia. Considering that all of these risk factors could influence the development of atrial fibrillation, an association between atrial fibrillation and the metabolic syndrome has been suggested. Additionally, oxidative stress and inflammation have been involved in the pathogenesis of both metabolic syndrome and atrial fibrillation. The mechanisms that relate metabolic syndrome to the increased risk of atrial fibrillation occurrence are not completely understood. Metabolic syndrome and atrial fibrillation are associated with increased cardiovascular morbidity and mortality. Because atrial fibrillation is the most common arrhythmia, and along with the prevalence of metabolic syndrome constantly increasing, it would be very important to determine the relationship between these 2 entities, especially due to the fact that the risk factors of metabolic syndrome are mainly correctable. This review focused on the available evidence supporting the association between metabolic syndrome components and metabolic syndrome as a clinical entity with atrial fibrillation.
C1 [Tadic, Marijana] Univ Clin Hosp Ctr Dr Dragisa Misovic, Dept Cardiol, Belgrade, Italy.
   [Ivanovic, Branislava] Clin Ctr Serbia, Clin Cardiol, Belgrade, Serbia.
   [Cuspidi, Cesare] Univ Milano Bicocca, Clin Res Unit, Meda, Italy.
   [Cuspidi, Cesare] Ist Auxol Italiano, Meda, Italy.
C3 Clinical Centre of Serbia; University of Milano-Bicocca; IRCCS Istituto
   Auxologico Italiano
RP Tadic, M (corresponding author), Univ Hosp Dr Dragisa Misovic, Heroja Milana Tepica 1, Belgrade 11000, Serbia.
EM marijana_tadic@hotmail.com
RI cuspidi, cesare/MHR-8423-2025
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NR 87
TC 30
Z9 31
U1 0
U2 12
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0160-9289
EI 1932-8737
J9 CLIN CARDIOL
JI Clin. Cardiol.
PD NOV
PY 2013
VL 36
IS 11
BP 654
EP 662
DI 10.1002/clc.22163
PG 9
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 248OU
UT WOS:000326711800003
PM 23788255
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Marcos-Delgado, A
   Hernández-Segura, N
   Fernández-Villa, T
   Molina, AJ
   Martín, V
AF Marcos-Delgado, Alba
   Hernandez-Segura, Natalia
   Fernandez-Villa, Tania
   Molina, Antonio J.
   Martin, Vicente
TI The Effect of Lifestyle Intervention on Health-Related Quality of Life
   in Adults with Metabolic Syndrome: A Meta-Analysis
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Review
DE metabolic syndrome; quality of life; healthy lifestyle; health
   education; exercise; diet therapy
ID WEIGHT-LOSS; PHYSICAL-ACTIVITY; SURVEY SF-36; PATIENT; IMPACT; TRIAL
AB The aim of this meta-analysis was to assess the effects of a lifestyle intervention through health education on nutrition, physical activity, and healthy habits on physical and mental health-related quality of life (HRQoL), in adults with metabolic syndrome (MetS). The databases used were PubMed, WOS, and Scopus. The inclusion criteria were: observational, longitudinal and randomized clinical trial (RCT) study designs, adults (both sexes), with at least two criteria of MetS, lifestyle intervention and comparison with a control group, and a measurement of HRQoL with a validated questionnaire. We analyzed the Hedges' g and SF-36 score. I-2 statistics were calculated and possible publication and small study biases were assessed using Egger's test and funnel plots. Seven RCTs were selected for meta-analysis, based on 637 study participants. Significant improvements were found in the physical dimensions of the HRQoL scores for subjects in the active intervention compared to the group that received general lifestyle information (Hedges' g 0.61, 95% confidence interval (CI) = 0.31-0.91). Mental health-related quality of life was also significantly improved in the intervention group compared with the control group (Hedges' g 0.84, 95% CI = 0.64-1.03). In conclusion, our results suggest that, according to the RCTs selected for this meta-analysis, a lifestyle intervention significantly improves HRQoL in all its domains.
C1 [Marcos-Delgado, Alba; Hernandez-Segura, Natalia; Fernandez-Villa, Tania; Molina, Antonio J.; Martin, Vicente] Univ Leon, Dept Ciencias Biomed, Area Med Prevent & Salud Publ, Leon 24071, Spain.
   [Martin, Vicente] Inst Salud Carlos III, CIBER Epidemiol & Salud Publ CIBERESP, Madrid 28029, Spain.
C3 Universidad de Leon; CIBER - Centro de Investigacion Biomedica en Red;
   CIBERESP; Instituto de Salud Carlos III
RP Fernández-Villa, T (corresponding author), Univ Leon, Dept Ciencias Biomed, Area Med Prevent & Salud Publ, Leon 24071, Spain.
EM amarcd@unileon.es; nhers@unileon.es; tferv@unileon.es;
   ajmolt@unileon.es; vmars@unileon.es
RI Marcos, Alba/AAN-4297-2020; MOLINA DE LA TORRE, ANTONIO/B-4328-2009;
   Hernandez-Segura, Natalia/AAJ-1267-2021; Villa, Tania/GLU-1260-2022;
   Martin, Vicente/A-1597-2008
OI Martin, Vicente/0000-0003-0552-2804; Marcos-Delgado,
   Alba/0000-0002-7852-1282; Hernandez-Segura, Natalia/0000-0002-5179-4475;
   Fernandez - Villa, Tania/0000-0002-9049-3026
FU Fondo de Investigacion para la Salud (FIS); European Regional
   Development Fund [PI17/00532]
FX This research was funded by Fondo de Investigacion para la Salud (FIS),
   which is co-funded by the European Regional Development Fund grant
   PI17/00532.
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NR 40
TC 29
Z9 30
U1 4
U2 18
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD FEB
PY 2021
VL 18
IS 3
AR 887
DI 10.3390/ijerph18030887
PG 14
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA QD1GT
UT WOS:000615276700001
PM 33498570
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Gomes-da-Costa, S
   Fernandéz-Pérez, I
   Borras, R
   Lopez, N
   Rivas, Y
   Ruiz, V
   Pons-Cabrera, MT
   Giménez-Palomo, A
   Anmella, G
   Valentí,
   Berk, M
   Vieta, E
   Pacchiarotti, I
AF Gomes-da-Costa, Susana
   Fernandez-Perez, Isabel
   Borras, Roger
   Lopez, Noelia
   Rivas, Yudith
   Ruiz, Victoria
   Pons-Cabrera, Maria Teresa
   Gimenez-Palomo, Anna
   Anmella, Gerard
   Valenti, Marc
   Berk, Michael
   Vieta, Eduard
   Pacchiarotti, Isabella
TI Is a vegetarian diet beneficial for bipolar disorder? Relationship
   between dietary patterns, exercise and pharmacological treatments with
   metabolic syndrome and course of disease in bipolar disorder
SO ACTA PSYCHIATRICA SCANDINAVICA
LA English
DT Article
DE bipolar disorder; diet; exercise; mental health; metabolic syndrome;
   nutrition
ID QUALITY-OF-LIFE; PHYSICAL-ACTIVITY; WEIGHT-GAIN; SCHIZOPHRENIA;
   PSYCHIATRY; OBESITY; PEOPLE; QUESTIONNAIRE; RELIABILITY; IMPAIRMENT
AB BackgroundLifestyle factors are being increasingly studied in bipolar disorder (BD) due to their possible effects on both course of disease and physical health. The aim of this study was to jointly describe and explore the interrelations between diet patterns, exercise, pharmacological treatment with course of disease and metabolic profile in BD.MethodsThe sample consisted of 66 euthymic or mild depressive individuals with BD. Clinical and metabolic outcomes were assessed, as well as pharmacological treatment or lifestyle habits (diet and exercise). Correlations were explored for different interrelations and a factor analysis of dietary patterns was performed.ResultsAdherence to the Mediterranean diet was low, seen in 37.9% of the patients and was positively associated with perceived quality of life. The amount of exercise was negatively associated with cholesterol levels, with 32.8% of participants rated as low active by International Physical Activity Questionnaire. There was a high prevalence of obesity (40.6%) and metabolic syndrome (29.7%). Users of lithium showed the best metabolic profile. Interestingly, three dietary patterns were identified: "vegetarian," "omnivore" and "Western." The key finding was the overall positive impact of the "vegetarian" pattern in BD, which was associated with reduced depression scores, better psychosocial functioning, and perceived quality of life, decreased body mass index, cholesterol, LDL and diastolic blood pressure. Nuts consumption was associated with a better metabolic profile.ConclusionsA vegetarian diet pattern was associated with both, better clinical and metabolic parameters, in patients with BD. Future studies should prioritize prospective and randomized designs to determine causal relationships, and potentially inform clinical recommendations.
C1 [Gomes-da-Costa, Susana; Borras, Roger; Gimenez-Palomo, Anna; Anmella, Gerard; Valenti, Marc; Vieta, Eduard; Pacchiarotti, Isabella] Univ Barcelona, Hosp Clin, Bipolar & Depress Disorders Unit, Inst Neurosci,IDIBAPS,CIBERSAM, 170 Villarroel St,12-0, Barcelona 08036, Catalonia, Spain.
   [Gomes-da-Costa, Susana; Lopez, Noelia; Rivas, Yudith; Ruiz, Victoria; Pons-Cabrera, Maria Teresa; Gimenez-Palomo, Anna; Anmella, Gerard; Valenti, Marc; Vieta, Eduard; Pacchiarotti, Isabella] Hosp Clin Barcelona, Inst Neurosci, Dept Psychiat & Psychol, Barcelona, Spain.
   [Gomes-da-Costa, Susana] Vidal i Barraquer Fdn, Sant Andreu Mental Hlth Care Ctr, Barcelona, Spain.
   [Fernandez-Perez, Isabel] Hosp Mar Res Inst, Neurosci Res Grp, Barcelona, Spain.
   [Pons-Cabrera, Maria Teresa] Univ Barcelona, Hosp Clin, Inst Neurosci, Hlth & Addict Res Grp,IDIBAPS, Barcelona, Spain.
   [Berk, Michael] Deakin Univ, IMPACT Inst Mental & Phys Hlth & Clin Translat, Food & Mood Ctr, Sch Med,Barwon Hlth, Geelong, Vic, Australia.
C3 University of Barcelona; Hospital Clinic de Barcelona; IDIBAPS; CIBER -
   Centro de Investigacion Biomedica en Red; CIBERSAM; University of
   Barcelona; Hospital Clinic de Barcelona; Hospital del Mar Research
   Institute; Hospital del Mar; University of Barcelona; Hospital Clinic de
   Barcelona; IDIBAPS; Deakin University; Barwon Health
RP Pacchiarotti, I (corresponding author), Univ Barcelona, Hosp Clin, Bipolar & Depress Disorders Unit, Inst Neurosci,IDIBAPS,CIBERSAM, 170 Villarroel St,12-0, Barcelona 08036, Catalonia, Spain.
EM pacchiar@clinic.cat
RI Vieta, Eduard/Y-2919-2019; Berk, Michael/AGH-9427-2022; Diaz,
   Gerard/AAB-7311-2021
OI Gomes da Costa, Susana/0000-0003-0383-0555; Anmella,
   Gerard/0000-0002-6798-4054
FU Vidal i Barraquer Foundation; Instituto de Salud Carlos III
   [PI21/00787]; Secretaria d'Universitats i Recerca del Departament
   d'Economia i Coneixement, CERCA Programme, Generalitat de Catalunya
   [2021-SGR-01358]; La Marato-TV3 Foundation [202234-30]; European Union
   [754907, 945151, 101057454]; EIT Health (EDIT-B project); Spanish
   Ministry of Health - Instituto de Salud Carlos III (ISCIII) [JR23/00050,
   CM21/00017, MV22/00058]; Fondo Social Europeo Plus (FSE+); European
   Social Fund+ (ESF+) [JR23/00050, CM21/00017, MV22/00058]; ISCIII
   [PI21/00340, PI21/00169]; Fundacio Vila Saborit; Milken Family
   Foundation [PI046998]; Societat Catalana de Psiquiatria i Salut Mental
   (SCPiSM); Fundacio Clinic per a la Recerca Biomedica (FCRB)-Pons Bartan
   2020 grant [PI04/6549]; NHMRC; Sociedad Espanola de Psiquiatria y Salud
   Mental (SEPSM);  [GNT2017131]; Horizon Europe - Pillar II [101057454]
   Funding Source: Horizon Europe - Pillar II
FX We are extremely grateful to all the participants. We thank the Vidal i
   Barraquer Foundation for the time and support. Also, we thank Joan
   Jimenez Balado for statistical support. The authors thank the support of
   the Instituto de Salud Carlos III (PI21/00787) the Secretaria
   d'Universitats i Recerca del Departament d'Economia i Coneixement
   (2021-SGR-01358), CERCA Programme, Generalitat de Catalunya; La
   Marato-TV3 Foundation grants 202234-30; the European Union Horizon 2020
   research and innovation program (H2020-EU.3.1.1.-Grant No 754907,
   H2020-EU.3.1.3.-Grant 945151, HORIZON.2.1.1-Grant 101057454) and EIT
   Health (EDIT-B project). GA is supported by a Juan Rodes 2023 grant
   (JR23/00050), a Rio Hortega 2021 grant (CM21/00017) and Accion
   Estrategica en Salud-Mobility (M-AES) fellowship (MV22/00058), from the
   Spanish Ministry of Health financed by the Instituto de Salud Carlos III
   (ISCIII) and co-financed by the Fondo Social Europeo Plus (FSE+). GA
   thanks the support of the Spanish Ministry of Health financed by the
   Instituto de Salud Carlos III (ISCIII) and co-financed by the European
   Social Fund+ (ESF+) (JR23/00050, MV22/00058, CM21/00017); the ISCIII
   (PI21/00340, PI21/00169); the Milken Family Foundation (PI046998); the
   Fundacio Clinic per a la Recerca Biomedica (FCRB)-Pons Bartan 2020 grant
   (PI04/6549), the Sociedad Espanola de Psiquiatria y Salud Mental
   (SEPSM); the Fundacio Vila Saborit; and the Societat Catalana de
   Psiquiatria i Salut Mental (SCPiSM). MB is supported by a NHMRC
   Leadership 3 Investigator grant (GNT2017131). The authors received no
   financial support for the research, authorship, or publication of this
   article.
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NR 59
TC 2
Z9 2
U1 1
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0001-690X
EI 1600-0447
J9 ACTA PSYCHIAT SCAND
JI Acta Psychiatr. Scand.
PD OCT
PY 2024
VL 150
IS 4
BP 209
EP 222
DI 10.1111/acps.13733
EA JUL 2024
PG 14
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA E4W1Z
UT WOS:001268028000001
PM 38994686
DA 2025-06-11
ER

PT J
AU Rosenson, RS
AF Rosenson, RS
TI Statins in atherosclerosis: Lipid-lowering agents with antioxidant
   capabilities
SO ATHEROSCLEROSIS
LA English
DT Review
DE atherosclerosis; lipoprotein; nitric oxide; oxidative stress; reactive
   oxygen species; statin
ID LOW-DENSITY-LIPOPROTEIN; CORONARY-HEART-DISEASE; NITRIC-OXIDE SYNTHASE;
   COA REDUCTASE INHIBITOR; ENDOTHELIUM-DEPENDENT VASODILATION;
   INSULIN-RESISTANCE SYNDROME; VITAMIN-E SUPPLEMENTATION; COPPER-INDUCED
   OXIDATION; 3RD NATIONAL-HEALTH; IN-VITRO OXIDATION
AB Low-density lipoprotein (LDL) cholesterol is an established risk factor for coronary heart disease (CHD). In the presence of oxidative stress LDL particles can become oxidized to form a lipoprotein species that is particularly atherogenic. Indeed, oxidized LDL (oxLDL) is pro-inflammatory, it can cause endothelial dysfunction and it readily accumulates within the arterial wall. Several factors may influence the susceptibility of LDL to oxidation, including its size and composition, and the presence of endogenous antioxidant compounds, such as alpha-tocopherol. Individuals with type 2 diabetes or the metabolic syndrome have high levels of oxidative stress and consequently are at an increased risk for cardiovascular events. Reducing oxidative stress has been proposed as a potential approach to prevent CHD and antioxidant vitamins have been employed with encouraging results in experimental models of atherosclerosis. However, clinical trials have not demonstrated consistent beneficial effects of antioxidants on cardiovascular outcomes. Statins (3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors) are the first-line choice for lowering total and LDL cholesterol levels and they have been proven to reduce the risk of CHD. Recent data suggest that these compounds, in addition to their lipid-lowering ability, can also reduce the production of reactive oxygen species and increase the resistance of LDL to oxidation. It may be that the ability of statins to limit the oxidation of LDL contributes to their effectiveness at preventing atherosclerotic disease. (C) 2004 Elsevier Ireland Ltd. All rights reserved.
C1 Northwestern Univ, Feinberg Sch Med, Prevent Cardiol Ctr, Chicago, IL 60611 USA.
C3 Northwestern University; Feinberg School of Medicine
RP Northwestern Univ, Feinberg Sch Med, Prevent Cardiol Ctr, 201 E Huron St,Galter Pavil,Suite 11-120, Chicago, IL 60611 USA.
EM r-rosenson@northwestern.edu
RI Rosenson, Robert/MDS-6957-2025
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NR 174
TC 209
Z9 245
U1 0
U2 22
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0021-9150
EI 1879-1484
J9 ATHEROSCLEROSIS
JI Atherosclerosis
PD MAR
PY 2004
VL 173
IS 1
BP 1
EP 12
DI 10.1016/S0021-9150(03)00239-9
PG 12
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 800DL
UT WOS:000220009000001
PM 15177118
DA 2025-06-11
ER

PT J
AU Shin, MJ
   Shim, E
   Kang, B
   Park, S
   Lee, SH
   Shim, CY
   Park, E
   Chung, N
AF Shin, Min-Jeong
   Shim, Eugene
   Kang, Borum
   Park, Sungha
   Lee, Sang-Hak
   Shim, Chi Young
   Park, Eunju
   Chung, Namsik
TI Increased Inflammation, Reduced Plasma Phospholipid Eicosapentaenoic
   Acid and Reduced Antioxidant Potential of Treated Hypertensive Patients
   with Metabolic Syndrome
SO YONSEI MEDICAL JOURNAL
LA English
DT Article
DE Metabolic syndrome X; hypertension; oxidative stress; eicosapentaenoic
   acid; antioxidants; cytokines
ID ISCHEMIC-HEART-DISEASE; INSULIN-RESISTANCE; OXIDATIVE STRESS; ORGAN
   DAMAGE; OLDER-ADULTS; FATTY-ACIDS; RISK; ADIPONECTIN; ATHEROSCLEROSIS;
   PROTEIN
AB Purpose: In the present study, we tested whether the presence of metabolic syndrome (MetS) would worsen the features of inflammation, plasma omega 3 fatty acid levels and antioxidant potential in treated hypertensive patients. Materials and Methods: Two groups were classified by the components of MetS: a reference group of treated hypertensive subjects: hypertension (HTN) group (n = 39) and with more than two additional MetS components: HTN with Mets group (n = 40). We further compared the parameters between HTN group and HTN with MetS group. Results: The results showed that age (p < 0.001) and body mass index (BMI) (p < 0.001) were significantly different between HTN group and HTN with MetS group. Age- and BMI-adjusted total radical trapping antioxidant potential (TRAP) (p < 0.01) was significantly lower, whereas age- and BMI-adjusted CID (p < 0.05) and interleukin (IL) 6 (p < 0.05) were significantly higher in HTN with MetS group than in HTN group. Moreover, HTN with MetS group had significantly lower levels of age- and BMI-adjusted plasma phospholipid eicosapentaenoic acid (EPA) than HTN group (p < 0.05). On the other hand, the levels of age- and BMI-adjusted intracellular cell adhesion molecule-1 (ICAM-1), adiponectin and high molecular weight (HMW)-adiponectin were not significantly different between the groups. Conclusion: In conclusion, our results showed increased inflammatory marker, reduced anfioxidant potential and EPA levels in treated hypertensive patients in the presence of MetS, suggesting the importance of changes of therapeutic lifestyle to modify the features of MetS.
C1 [Park, Sungha; Lee, Sang-Hak; Shim, Chi Young; Chung, Namsik] Yonsei Univ, Coll Med, Dept Internal Med, Div Cardiol, Seoul 120752, South Korea.
   [Shin, Min-Jeong; Kang, Borum] Korea Univ, Dept Food & Nutr, Seoul, South Korea.
   [Shim, Eugene] Yonsei Univ Hlth Syst, Natl Hypertens Ctr, Seoul, South Korea.
   [Park, Eunju] Kyungnam Univ, Dept Food & Nutr, Masan, South Korea.
C3 Yonsei University; Yonsei University Health System; Korea University;
   Yonsei University; Yonsei University Health System; Kyungnam University
RP Chung, N (corresponding author), Yonsei Univ, Coll Med, Dept Internal Med, Div Cardiol, 250 Seongsan Ro, Seoul 120752, South Korea.
EM namsikc@yuhs.ac
RI CHIA, YOOK CHIN/B-8379-2010; Chow, Elaine/HJB-2197-2022; Park,
   Eunju/AAF-9669-2021; Shim, Chi/AAK-1057-2021
OI Shim, Chi Young/0000-0002-6136-0136; Park, Sungha/0000-0001-5362-478X
FU Korea government (MOST) [R01-2008-000-20879-0]
FX This work was supported by the Korea Science and Engineering Foundation
   (KOSEF) grant funded by the Korea government (MOST)
   (R01-2008-000-20879-0).
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NR 38
TC 4
Z9 4
U1 0
U2 4
PU YONSEI UNIV COLL MEDICINE
PI SEOUL
PA 50-1 YONSEI-RO, SEODAEMUN-GU, SEOUL 120-752, SOUTH KOREA
SN 0513-5796
EI 1976-2437
J9 YONSEI MED J
JI Yonsei Med. J.
PD DEC 31
PY 2009
VL 50
IS 6
BP 757
EP 763
DI 10.3349/ymj.2009.50.6.757
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 535TH
UT WOS:000272993700004
PM 20046414
OA Green Submitted, gold, Green Published
DA 2025-06-11
ER

PT J
AU Ribeiro, ACAF
   Batista, TH
   Rojas, VCT
   Giusti-Paiva, A
   Vilela, FC
AF Alves Freire Ribeiro, Ana Claudia
   Batista, Tatiane Helena
   Trujillo Rojas, Viviana Carolina
   Giusti-Paiva, Alexandre
   Vilela, Fabiana Cardoso
TI Metabolic syndrome accentuates post-traumatic stress disorder-like
   symptoms and glial activation
SO BEHAVIOURAL BRAIN RESEARCH
LA English
DT Article
DE Fructose; PTSD-like symptoms; GFAP; Iba-1
ID FRUCTOSE; RATS; COMORBIDITY; IMPAIRMENT; PREVALENCE; DEPRESSION;
   MICROGLIA; BEHAVIOR; ANXIETY; RISK
AB The relationship between individuals with post-traumatic stress disorder (PTSD) and the development of metabolic syndrome (MS) is well understood, but the relationship between individuals with preexisting MS and the development of PTSD is not yet known. Therefore, we evaluated the course of PTSD development in preexisting MS rats and we quantified the glial fibrillary acidic protein (GFAP) and ionized the calcium binding adaptor molecule 1 (Iba-1) in the cortex and hippocampus of the experimental animals. Male Wistar rats were divided into two groups: control or 10 % fructose for 5 weeks. After 5 weeks of MS induction, a group of animals was used to characterize MS. In another group, after 5 weeks of MS induction, animals were exposed to or not exposed to inescapable footshocks, followed by social isolation. After 14 days of a retention interval, the animals were re-exposed to the inescapable footshocks box, and the freezing time was evaluated. Over the following days, the animals were tested using the open field, social interaction and forced swimming tests, respectively. In another group of animals, after induction of MS and PTSD as previously described, elevated plus maze and object recognition tests were performed. Our results demonstrate that fructose solution for 5 weeks was able to induce MS, and animals with MS had more pronounced PTSD-like symptoms and a greater increase in GFAP and Iba-1 in the hippocampus and prefrontal cortex. In conclusion, MS accentuated PTSD-like symptoms that may be related to increased glial activation. This study helps reveal factors that may predispose individuals to the development of PTSD, such as metabolic disorders.
C1 [Alves Freire Ribeiro, Ana Claudia; Batista, Tatiane Helena; Trujillo Rojas, Viviana Carolina; Giusti-Paiva, Alexandre; Vilela, Fabiana Cardoso] Univ Fed Alfenas Unifal MG, Inst Ciencias Biomed, Alfenas, Brazil.
C3 Universidade Federal de Alfenas
RP Vilela, FC (corresponding author), Univ Fed Alfenas, UNIFAL, Inst Ciencias Biomed, Ave Jovino Fernandes Sales 2600, BR-37130000 Alfenas, MG, Brazil.
EM facvilela@gmail.com
RI Giusti-Paiva, Alexandre/F-3531-2010; Rojas, Viviana/AAJ-9291-2021
OI Vilela, Fabiana/0000-0001-8691-3748; Giusti-Paiva,
   Alexandre/0000-0001-5059-9988; Helena Batista,
   Tatiane/0000-0003-2679-1026; Trujillo Rojas, Viviana
   Carolina/0000-0002-0094-965X
FU Fundacao de Amparo a Pesquisa de Minas Gerais (FAPEMIG) [03346-18];
   Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
   [429035/2018-7]
FX This work was supported by Fundacao de Amparo a Pesquisa de Minas Gerais
   (FAPEMIG #03346-18, AG-P) and Conselho Nacional de Desenvolvimento
   Cientifico e Tecnologico (CNPq, #429035/2018-7; FCV). The FAPEMIG and
   CNPq had no further role in the design of the study; the collection,
   analysis, and interpretation of the data; the writing of the report; or
   the decision to submit the paper for publication.
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NR 40
TC 13
Z9 13
U1 0
U2 3
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0166-4328
EI 1872-7549
J9 BEHAV BRAIN RES
JI Behav. Brain Res.
PD APR 20
PY 2020
VL 384
AR 112557
DI 10.1016/j.bbr.2020.112557
PG 8
WC Behavioral Sciences; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Behavioral Sciences; Neurosciences & Neurology
GA LD5JZ
UT WOS:000526067300013
PM 32061590
DA 2025-06-11
ER

PT J
AU Khomami, MB
   Teede, HJ
   Joham, AE
   Moran, LJ
   Piltonen, TT
   Boyle, JA
AF Khomami, Mahnaz Bahri
   Teede, Helena J.
   Joham, Anju E.
   Moran, Lisa J.
   Piltonen, Terhi T.
   Boyle, Jacqueline A.
TI Clinical management of pregnancy in women with polycystic ovary
   syndrome: An expert opinion
SO CLINICAL ENDOCRINOLOGY
LA English
DT Review
DE antenatal care; gestational weight gain; guideline; lifestyle;
   polycystic ovary syndrome; pregnancy; screening; treatment
ID BODY-MASS INDEX; GESTATIONAL WEIGHT-GAIN; CARDIOVASCULAR RISK;
   PHYSICAL-ACTIVITY; OBESITY; INFERTILITY; PREVALENCE; OUTCOMES; IMPACT
AB Polycystic ovary syndrome (PCOS) is associated with a higher risk for pregnancy and birth complications according to the specific features associated with PCOS. The features include obesity before and during pregnancy, hyperandrogenism, insulin resistance, infertility, cardiometabolic risk factors, and poor mental health. PCOS is not often recognized as a risk factor for poor pregnancy and birth outcomes in pregnancy care guidelines, while its associated features are. Pregnancy-related risk profile should ideally be assessed for modifiable risk factors (e.g., lifestyle and weight management) at preconception in women with PCOS. Hyperglycaemia should be screened using a 75-g oral glucose tolerance test at preconception or within the first 20 weeks of pregnancy if it has not been performed at preconception and should be repeated at 24-28 weeks of pregnancy. In the absence of evidence of benefit for strategies specific to women with PCOS, the international evidence-based guidelines for the assessment and management of PCOS recommend screening, optimizing, and monitoring risk profile in women with PCOS (at preconception, during and postpregnancy) consistent with the recommendations for the general population. Recommended factors include blood glucose, weight, blood pressure, smoking, alcohol, diet, exercise, sleep and mental health, emotional, and sexual health among women with PCOS. The guidelines recommend Metformin in addition to lifestyle for assisting with weight management and improving cardiometabolic risk factors, particularly in those with overweight or obesity. Letrozole is considered the first-line pharmacological treatment for anovulatory infertility in PCOS. Individualized approach should be considered in the management of pregnancy in PCOS.
C1 [Khomami, Mahnaz Bahri; Teede, Helena J.; Joham, Anju E.; Moran, Lisa J.; Boyle, Jacqueline A.] Monash Univ, Fac Med Nursing & Hlth Sci, Monash Ctr Hlth Res & Implementat, Sch Publ Hlth & Prevent Med, Level 1,43-51 Kanooka Grove, Clayton, Vic 3168, Australia.
   [Teede, Helena J.; Joham, Anju E.; Boyle, Jacqueline A.] Monash Hlth, Melbourne, Vic, Australia.
   [Piltonen, Terhi T.] Univ Oulu, Oulu Univ Hosp, Med Res Ctr, Dept Obstet & Gynecol,PEDEGO Res Unit, Oulu, Finland.
C3 Monash University; Monash Health; University of Oulu
RP Khomami, MB (corresponding author), Monash Univ, Fac Med Nursing & Hlth Sci, Monash Ctr Hlth Res & Implementat, Sch Publ Hlth & Prevent Med, Level 1,43-51 Kanooka Grove, Clayton, Vic 3168, Australia.
EM mahnaz.bahrikhomami@monash.edu
RI Khomami, Mahnaz/AAR-4972-2021; Moran, Lisa/E-9850-2015; Boyle,
   Jacqueline/AAD-3246-2019; Joham, Anju/AAD-6020-2019; Piltonen,
   Terhi/CAH-4447-2022
OI Teede, Helena/0000-0001-7609-577X; Joham, Anju/0000-0002-6307-2568;
   Moran, Lisa/0000-0001-5772-6484; Boyle, Jacqueline/0000-0002-3616-1637;
   Piltonen, Terhi/0000-0002-9921-7300; Bahri Khomami,
   Mahnaz/0000-0002-5955-1283
FU National Health and Medical Research Council [2009326]; National Heart
   Foundation of Australia [101169]; Australian government's Medical
   Research Future Fund [1199826]; Centre for Research Excellence in
   Women's Health in Reproductive Life; Academy of Finland [315921,
   321763]; Novo Nordisk Foundation [NNF21OC0070372]; Juselius Foundation;
   National Health and Medical Research Council of Australia [2009326]
   Funding Source: NHMRC
FX National Health and Medical Research Council, Grant/Award Number:
   2009326; National Heart Foundation of Australia, Grant/Award Number:
   101169; The Australian government's Medical Research Future Fund,
   Grant/Award Number: 1199826; The Centre for Research Excellence in
   Women's Health in Reproductive Life; Academy of Finland, Grant/Award
   Numbers: 315921, 321763; Novo Nordisk Foundation, Grant/Award Number:
   NNF21OC0070372; Juselius Foundation
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NR 85
TC 20
Z9 20
U1 3
U2 25
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0300-0664
EI 1365-2265
J9 CLIN ENDOCRINOL
JI Clin. Endocrinol.
PD AUG
PY 2022
VL 97
IS 2
SI SI
BP 227
EP 236
DI 10.1111/cen.14723
EA APR 2022
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 2V0JW
UT WOS:000780958200001
PM 35383999
OA Green Published
DA 2025-06-11
ER

PT J
AU Wang, QJ
   Guo, Y
   Yao, CY
   Zhang, KH
   Li, Q
   Shan, CH
   Liu, P
   Wang, MZ
   Zhu, F
   An, L
   Tian, JH
   Wu, ZH
AF Wang, Qiang-Jun
   Guo, Yao
   Yao, Chun-Yan
   Zhang, Ke-Hao
   Li, Qin
   Shan, Chun-Hua
   Liu, Peng
   Wang, Mei-Zhi
   Zhu, Feng
   An, Lei
   Tian, Jian-Hui
   Wu, Zhong-Hong
TI Loss of diurnal behavioral rhythms and impaired lipid metabolism in
   growing pigs with mistimed feeding
SO FASEB JOURNAL
LA English
DT Article
DE behavioral rhythms; circadian rhythm; feeding time; growing pig;
   metabolic syndrome
ID CHAIN FATTY-ACIDS; GUT MICROBIOTA; OXIDATIVE STRESS; CIRCADIAN CLOCK;
   RECEPTOR; HEALTH; DIET; LIPOPOLYSACCHARIDE; ADIPOSITY; PATTERN
AB The misalignment of eating time and the endogenous circadian rhythm impairs the body's ability to maintain homeostasis. Although it is well established that children and growing animals differ from adults in their energy metabolism and behavioral patterns, little is known about how mistimed feeding disturbs the diurnal rhythms of behavior and metabolism in children and growing diurnal animals. In this study, growing pigs (diurnal animal) were randomly assigned to the daytime-restricted feeding (DRF) and nighttime-restricted feeding (NRF) groups for 5 weeks. Compared with observations in the DRF group, NRF disrupted the diurnal rhythm of behavior and clock genes and lowered the serum ghrelin, dopamine, and serotonin levels during the daytime and nighttime. Microbiome analysis results suggested that NRF altered the diurnal rhythm and composition of the gut microbiota, and increased log-ratios of Catenibacterium:Butyrivibrio and Streptococcus:Butyrivibrio. Based on the serum proteome, the results further revealed that rhythmic and upregulated proteins in NRF were mainly involved in oxidative stress, lipid metabolism, immunity, and cancer biological pathways. Serum physiological indicators further confirmed that NRF decreased the concentration of melatonin and fibroblast growth factor 21 during the daytime and nighttime, increased the diurnal amplitude and concentrations of very-low-density lipoprotein cholesterol, triglyceride, and total cholesterol, and increased the apolipoprotein B/ApoA1 ratio, which is a marker of metabolic syndrome. Taken together, this study is the first to reveal that mistimed feeding disrupts the behavioral rhythms of growing pigs, reprograms gut microbiota composition, reduces the serum levels of hormones associated with fighting depression and anxiety, and increases the risk of lipid metabolic dysregulation.
C1 [Wang, Qiang-Jun; Guo, Yao; Yao, Chun-Yan; Zhang, Ke-Hao; Li, Qin; Shan, Chun-Hua; Liu, Peng; Wang, Mei-Zhi; Zhu, Feng; Wu, Zhong-Hong] China Agr Univ, Coll Anim Sci & Technol, State Key Lab Anim Nutr, 2 Yuanmingyuan West Rd, Beijing 100193, Peoples R China.
   [An, Lei; Tian, Jian-Hui] China Agr Univ, Coll Anim Sci & Technol, Key Lab Anim Genet Breeding & Reprod, Minist Agr & Rural Affairs,Natl Engn Lab Anim Bre, Beijing, Peoples R China.
C3 China Agricultural University; China Agricultural University; Ministry
   of Agriculture & Rural Affairs
RP Wu, ZH (corresponding author), China Agr Univ, Coll Anim Sci & Technol, State Key Lab Anim Nutr, 2 Yuanmingyuan West Rd, Beijing 100193, Peoples R China.
EM wuzhh@cau.edu.cn
RI Li, QIn/GXA-1934-2022; Wang, Qiang-Jun/KVY-3418-2024; Yao,
   Chunyan/G-9897-2012; An, Lei/GQB-0039-2022
OI Guo, Yao/0000-0002-4691-5623; Wang, Qiang-Jun/0000-0003-2060-1527
FU National Key Research and Development Program of China [2016YFD0500506];
   Beijing Innovation Consortium of Agriculture Research System
   [BAIC02-2021]; China Agriculture Research System [CARS-43-D-1]
FX National Key Research and Development Program of China, Grant/Award
   Number: 2016YFD0500506; Beijing Innovation Consortium of Agriculture
   Research System, Grant/Award Number: BAIC02-2021; China Agriculture
   Research System, Grant/Award Number: CARS-43-D-1
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NR 80
TC 10
Z9 10
U1 2
U2 28
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0892-6638
EI 1530-6860
J9 FASEB J
JI Faseb J.
PD NOV
PY 2021
VL 35
IS 11
AR e21972
DI 10.1096/fj.202100768R
PG 16
WC Biochemistry & Molecular Biology; Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA WN8IK
UT WOS:000712009200020
PM 34613642
DA 2025-06-11
ER

PT J
AU Filgueiras, MS
   Rocha, NP
   Novaes, JF
   Bressan, J
AF Filgueiras, M. S.
   Rocha, N. P.
   Novaes, J. F.
   Bressan, J.
TI Vitamin D status, oxidative stress, and inflammation in children and
   adolescents: A systematic review
SO CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
LA English
DT Review
DE Vitamin D deficiency; biomarkers; inflammation mediators; antioxidants;
   calcifediol; child; adolescent
ID 25-HYDROXYVITAMIN D DATA; D DEFICIENCY; INSULIN-RESISTANCE; METABOLIC
   SYNDROME; RISK-FACTORS; CATHEPSIN S; CYSTATIN-D; D-RECEPTOR; BODY-FAT;
   OBESITY
AB Vitamin D deficiency is considered a global public health problem with high prevalence in children and adolescents. The majority of the studies in the literature have identified a relationship between vitamin D insufficiency/deficiency and obesity, as well as other traditional cardiometabolic risk factors in children and adolescents. Scarce studies address vitamin D status with oxidative stress and inflammation in the young population. The aim of this systematic review was to evaluate the evidence of the association of vitamin D status with oxidative stress and inflammation in children and adolescents. This is a systematic review based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyzes (PRISMA) guideline on reporting systematic reviews. Eight studies were selected for this review. All included studies evaluated inflammatory biomarkers and two out of eight evaluated biomarkers of oxidative stress. The majority of the studies (five out of eight) found association of vitamin D status with biomarkers of oxidative stress and inflammation such as C-reactive protein (CRP), interleukin-6 (IL-6), cathepsin S, vascular cell adhesion molecule-1 (VCAM-1), malondialdehyde (MDA), myeloperoxidase, 3-nitrotyrosine, and superoxide dismutase (SOD). Vitamin D status is associated with oxidative stress and inflammation in the majority of the studies with children and adolescents. Thus, the assessment of vitamin D status is important because it is associated with nontraditional cardiometabolic markers in the pediatric population (review registration: PROSPERO CRD42018109307).
C1 [Filgueiras, M. S.; Rocha, N. P.; Novaes, J. F.; Bressan, J.] Univ Fed Vicosa, Dept Nutr & Hlth, BR-36570900 Vicosa, MG, Brazil.
C3 Universidade Federal de Vicosa
RP Filgueiras, MS (corresponding author), Univ Fed Vicosa, Dept Nutr & Hlth, BR-36570900 Vicosa, MG, Brazil.
EM mariana.filgueiras@ufv.br
RI Bressan, Josefina/A-2598-2009; Filgueiras, Mariana/Q-6096-2018
OI Filgueiras, Mariana/0000-0003-1932-6126; Bressan,
   Josefina/0000-0002-4993-9436
FU Foundation for Research Support of the state of Minas Gerais (FAPEMIG);
   Coordination for the Improvement of Higher Education Personnel (CAPES)
FX We thank Foundation for Research Support of the state of Minas Gerais
   (FAPEMIG) and Coordination for the Improvement of Higher Education
   Personnel (CAPES) for granting doctoral scholarships for M.S.F. and
   N.P.R.
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NR 69
TC 66
Z9 69
U1 0
U2 40
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1040-8398
EI 1549-7852
J9 CRIT REV FOOD SCI
JI Crit. Rev. Food Sci. Nutr.
PD FEB 21
PY 2020
VL 60
IS 4
BP 660
EP 669
DI 10.1080/10408398.2018.1546671
PG 10
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA KC6DX
UT WOS:000507267000008
PM 30596263
DA 2025-06-11
ER

PT J
AU Haymana, C
   Aydogdu, A
   Soykut, B
   Erdem, O
   Ibrahimov, T
   Dinc, M
   Meric, C
   Basaran, Y
   Sonmez, A
   Azal, O
AF Haymana, C.
   Aydogdu, A.
   Soykut, B.
   Erdem, O.
   Ibrahimov, T.
   Dinc, M.
   Meric, C.
   Basaran, Y.
   Sonmez, A.
   Azal, O.
TI Oxidative stress status in congenital hypogonadism: an appraisal
SO TOXICOLOGY MECHANISMS AND METHODS
LA English
DT Article
DE Hypogonadism; oxidative stress; cardiometabolic diseases; insulin
   resistance; testosterone
ID HORMONE-BINDING GLOBULIN; LOW-DENSITY-LIPOPROTEIN; METABOLIC SYNDROME;
   ENDOTHELIAL DYSFUNCTION; INSULIN-RESISTANCE; FREE TESTOSTERONE;
   SEX-HORMONES; PLASMA; MALONDIALDEHYDE; INFLAMMATION
AB Patients with hypogonadism are at increased risk of cardiac and metabolic diseases. However, the pathogenesis of increased cardiometabolic risk in patients with hypogonadism is not clear. Oxidative stress plays an important role in the pathogenesis of cardiometabolic diseases. This study aimed to investigate possible differences in oxidative stress conditions between patients with hypogonadism and healthy controls. In this study, 38 male patients with congenital hypogonadotropic hypogonadism (CHH) (mean age: 21.7 +/- 1.6 years) and 44 healthy male controls (mean age: 22.3 +/- 1.4 years) with almost equal body mass index were enrolled. The demographic parameters, follicle-stimulating hormone (FSH), luteinizing hormone (LH), total and free testosterone, homeostatic model assessment of insulin resistance (HOMA-IR) and oxidative stress parameters, such as superoxide dismutase, catalase (CAT), glutathione peroxidase (GPx) and malondialdehyde (MDA), were compared between both groups. Compared to the healthy controls, triglycerides (p = .02), insulin levels, HOMA-IR values, CAT activities and MDA levels (p < .001 for all) were significantly higher and HDL cholesterol (p = .04), total and free testosterone, FSH, LH levels and GPx activity were significantly lower (p < .001 for all) in patients with CHH. There were significant correlations between total testosterone levels and CAT activity (r = .33 p = .01), GPx activity (r = .36 p = .007) and MDA (r = .47 p < .001) levels. The results of this study showed that young and treatment-naive patients with congenital hypogonadism had an increased status of oxidative stress.
C1 [Haymana, C.; Aydogdu, A.; Ibrahimov, T.; Dinc, M.; Meric, C.; Basaran, Y.; Sonmez, A.; Azal, O.] Gulhane Training & Res Hosp, Dept Endocrinol & Metab, Gen Tevfik Saglam St, TR-06010 Ankara, Turkey.
   [Soykut, B.; Erdem, O.] Gulhane Training & Res Hosp, Dept Pharmaceut Toxicol, Ankara, Turkey.
C3 Gulhane Training & Research Hospital; Gulhane Training & Research
   Hospital
RP Haymana, C (corresponding author), Gulhane Training & Res Hosp, Dept Endocrinol & Metab, Gen Tevfik Saglam St, TR-06010 Ankara, Turkey.
EM cemhaymana@hotmail.com
RI Meriç, Coşkun/AAI-1482-2021; Dinç, Mustafa/AAG-7771-2019; haymana,
   cem/Y-6947-2019; Soykut, Bugra/AAP-2045-2021; Sonmez, Alper/H-8588-2019;
   Dinc, Mustafa/K-3512-2015
OI Sonmez, Alper/0000-0002-9309-7715; Meric, Coskun/0000-0002-0766-0517;
   haymana, cem/0000-0002-6866-2364; Dinc, Mustafa/0000-0002-1436-031X
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NR 39
TC 7
Z9 7
U1 0
U2 7
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1537-6516
EI 1537-6524
J9 TOXICOL MECH METHOD
JI Toxicol. Mech. Methods
PY 2017
VL 27
IS 6
BP 451
EP 457
DI 10.1080/15376516.2017.1320693
PG 7
WC Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Toxicology
GA EV8DE
UT WOS:000402009900007
PM 28413915
DA 2025-06-11
ER

PT J
AU Cosan, AS
   Schweiger, JU
   Kahl, KG
   Hamann, B
   Deuschle, M
   Schweiger, U
   Westermair, AL
AF Cosan, Alisa S.
   Schweiger, Julietta U.
   Kahl, Kai G.
   Hamann, Bettina
   Deuschle, Michael
   Schweiger, Ulrich
   Westermair, Anna L.
TI Fat compartments in patients with depression: A meta-analysis
SO BRAIN AND BEHAVIOR
LA English
DT Review
DE depression; intra&#8208; abdominal fat; major depressive disorder;
   metabolic syndrome; subcutaneous fat
ID BODY-MASS INDEX; VISCERAL FAT; METABOLIC SYNDROME; MAJOR DEPRESSION;
   ADIPOSE-TISSUE; SYMPTOMS; WOMEN; ASSOCIATION; OBESITY; DISORDER
AB Introduction Depressive disorders are a common illness worldwide. Major depression is known as a significant predictor of the metabolic syndrome. However, the effects of depression on adipose tissue compartments are controversial. This meta-analysis aimed to evaluate the state of research on the relationship between patients with depression and adipose tissue compartments as compared to nondepressed individuals.
   Methods The PubMed database was searched for human studies that measured adipose tissue compartments such as visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT) and/or organ-specific adipose tissue measurements using dual-energy X-ray absorptiometry, magnetic resonance imaging or computed tomography scan and reported the means and a measure of variance separately for depressed individuals and healthy controls. Twelve articles were identified, including a total of 1,141 depressed and 2,545 nondepressed individuals.
   Results Major depressive disorder and self-reported depressive symptoms were associated with elevated visceral adipose tissue and elevated subcutaneous adipose tissue. Subanalyses for gender, age, method of adipose tissue measurement, and method of depression assessment showed elevated visceral adipose in depressed individuals. The results could be replicated when focussing on studies controlling for body mass index (BMI). Regarding other adipose tissue compartments, meta-analysis could not be carried out due to lack of studies.
   Conclusions Depression is associated with enlarged visceral and subcutaneous adipose tissue. Further, especially longitudinal, research is needed to identify the mechanism through which depressive disorders contribute to visceral adiposity.
C1 [Cosan, Alisa S.; Schweiger, Ulrich; Westermair, Anna L.] Univ Lubeck, Klin Psychiat & Psychotherapie, Ratzeburger Allee 160, D-23538 Lubeck, Germany.
   [Schweiger, Julietta U.] LADR Geesthacht, Geesthacht, Germany.
   [Kahl, Kai G.] Hannover Med Sch, Klin Psychiat Sozialpsychiat & Psychotherapie, Hannover, Germany.
   [Hamann, Bettina] Kerkhoff Klin, Bad Nauheim, Germany.
   [Deuschle, Michael] Heidelberg Univ, Fak Med Mannheim, Zentralinst Seel Gesundheit, Mannheim, Germany.
C3 University of Lubeck; Hannover Medical School; Ruprecht Karls University
   Heidelberg; Central Institute of Mental Health
RP Westermair, AL (corresponding author), Univ Lubeck, Klin Psychiat & Psychotherapie, Ratzeburger Allee 160, D-23538 Lubeck, Germany.
EM anna.westermair@usb.ch
RI Westermair, Anna/AGO-2783-2022
OI Westermair, Anna/0000-0002-3673-4589
FU ProjektDEAL
FX Open access funding enabled and organized by ProjektDEAL.
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NR 50
TC 13
Z9 13
U1 0
U2 8
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 2162-3279
J9 BRAIN BEHAV
JI Brain Behav.
PD JAN
PY 2021
VL 11
IS 1
AR e01912
DI 10.1002/brb3.1912
EA NOV 2020
PG 10
WC Behavioral Sciences; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Behavioral Sciences; Neurosciences & Neurology
GA PZ9NT
UT WOS:000585209500001
PM 33150726
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Proeschold-Bell, RJ
   Swift, R
   Moore, HE
   Bennett, G
   Li, XF
   Blouin, R
   Williams, VP
   Williams, RB
   Toole, D
AF Proeschold-Bell, Rae Jean
   Swift, Robin
   Moore, H. Edgar
   Bennett, Gary
   Li, Xiang-Fang
   Blouin, Rachel
   Williams, Virginia P.
   Williams, Redford B., Jr.
   Toole, David
TI Use of a randomized multiple baseline design: Rationale and design of
   the Spirited Life holistic health intervention study
SO CONTEMPORARY CLINICAL TRIALS
LA English
DT Article
DE Randomized controlled trial; Multiple baseline design; Clergy; Metabolic
   syndrome; Depression
ID HEART-DISEASE; CLERGY HUSBANDS; WEIGHT-LOSS; STRESS; WORK; OBESITY;
   DEPRESSION; MANAGEMENT; BEHAVIOR; SUPPORT
AB Clergy suffer from high rates of obesity, chronic disease, and depression, and simultaneously underestimate the toll these take on their daily functioning. Health interventions are needed for clergy and may be tailored to their occupational context and theological beliefs. Few studies have sought to improve clergy health. No prior studies have utilized a randomized design. Spirited Life is a randomized, multiple baseline study that offered enrollment to nearly all United Methodist Church clergy in North Carolina in fall 2010. A total of 1114 clergy (response rate = 64%) enrolled. Using a multiple baseline design, we randomized participants to three cohorts. Each cohort began the health intervention in one of three consecutive years. The third cohort served as a randomized waitlist control cohort, allowing comparisons between the first and third cohorts. The two-year Spirited Life intervention consists of: 1) a theological underpinning for health stewardship based on incarnation, grace, and response and delivered during workshops; 2) the stress management program Williams LifeSkills; 3) Naturally Slim, an online weight loss program; 4) phone contact with a Wellness Advocate; and 5) $500 small grants for health goals. Metabolic syndrome is the primary endpoint. Stress and depressive severity are secondary endpoints. We measured each construct before, twice during, and at the end of the two-year intervention. Study outcomes, to be published after follow-up data are gathered, will provide evidence of the effectiveness of the combined intervention components of Spirited Life. If successful, the intervention may be considered for use with other clergy and faith populations. (C) 2013 Elsevier Inc. All rights reserved.
C1 [Proeschold-Bell, Rae Jean] Duke Global Hlth Inst, Durham, NC 27708 USA.
   [Proeschold-Bell, Rae Jean] Duke Ctr Hlth Policy & Inequal Res, Durham, NC 27708 USA.
   [Swift, Robin; Moore, H. Edgar; Li, Xiang-Fang; Blouin, Rachel; Toole, David] Duke Divin Sch, Durham, NC 27701 USA.
   [Bennett, Gary] Duke Univ, Dept Psychol & Neurosci, Durham, NC 27708 USA.
   [Williams, Virginia P.] Williams LifeSkills, Durham, NC 27705 USA.
   [Williams, Redford B., Jr.] Duke Univ, Dept Psychiat & Behav Sci, Durham, NC 27705 USA.
   [Williams, Redford B., Jr.] Duke Univ, Dept Med & Psychol & Neurosci, Durham, NC 27705 USA.
   [Toole, David] Duke Global Hlth Inst, Durham, NC 27701 USA.
C3 Duke University; Duke University; Duke University; Duke University; Duke
   University; Duke University
RP Proeschold-Bell, RJ (corresponding author), Duke Global Hlth Inst, Box 90392, Durham, NC 27708 USA.
EM rae.jean@duke.edu; rswift@div.duke.edu; hmoore@div.duke.edu;
   gary.bennett@duke.edu; xfli@div.duke.edu; rblouin@div.duke.edu;
   Virginia@williamslifeskills.com; redfordw@duke.edu; dtoole@div.duke.edu
FU Rural Church Area of The Duke Endowment
FX This research was funded by a grant from the Rural Church Area of The
   Duke Endowment. We would like to thank program officers Joe Mann and
   Robb Webb not only for the funding but also for their role as strategic
   collaborators who have been essential in the design of the Spirited Life
   program. We wish to thank Bishop Alfred Gwinn and Bishop Hope Morgan
   Ward of the North Carolina UMC Conference, and Bishop Larry Goodpaster
   of the Western North Carolina UMC Conference, for encouraging clergy to
   participate in Spirited Life. We offer a special thanks to all clergy
   participants. We also thank Spirited Life's thirteen Wellness Advocates,
   who have shaped the program in substantial and important ways. We are
   indebted to Marcia Upson, President of Naturally Slim, for her
   collaboration and design of the Naturally Slim product We also wish to
   thank our partners, Crystal MacAllum, Gail Thomas, and Ed Mann from
   Westat, for their superb survey and programming data collection efforts;
   Rachel Meyer and Alana Bennett for excellence in health screening data
   collection; and Melanie Kolkin and two anonymous reviewers for their
   editorial expertise.
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NR 92
TC 18
Z9 23
U1 1
U2 17
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1551-7144
EI 1559-2030
J9 CONTEMP CLIN TRIALS
JI Contemp. Clin. Trials
PD JUL
PY 2013
VL 35
IS 2
BP 138
EP 152
DI 10.1016/j.cct.2013.05.005
PG 15
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA 193LI
UT WOS:000322560900015
PM 23685205
DA 2025-06-11
ER

PT J
AU Vigna, L
   Brunani, A
   Brugnera, A
   Grossi, E
   Compare, A
   Tirelli, AS
   Conti, DM
   Agnelli, GM
   Andersen, LL
   Buscema, M
   Riboldi, L
AF Vigna, Luisella
   Brunani, Amelia
   Brugnera, Agostino
   Grossi, Enzo
   Compare, Angelo
   Tirelli, Amedea S.
   Conti, Diana M.
   Agnelli, Gianna M.
   Andersen, Lars L.
   Buscema, Massimo
   Riboldi, Luciano
TI Determinants of metabolic syndrome in obese workers: gender differences
   in perceived job-related stress and in psychological characteristics
   identified using artificial neural networks
SO EATING AND WEIGHT DISORDERS-STUDIES ON ANOREXIA BULIMIA AND OBESITY
LA English
DT Article
DE Obesity; Metabolic syndrome; Gender; Eating disorders; Depression;
   Occupational determinants; ANN; Occupational physical activity
ID OCCUPATIONAL PHYSICAL-ACTIVITY; WORLD-HEALTH-ORGANIZATION; BINGE-EATING
   DISORDER; BODY-MASS INDEX; CARDIOVASCULAR-DISEASE; RISK-FACTORS;
   WEIGHT-GAIN; DEPRESSION; PREVALENCE; BEHAVIORS
AB Objective The metabolic syndrome (MS) is a multifactorial disorder associated with a higher risk of developing cardiovascular diseases and type 2 diabetes. However, its pathophysiology and risk factors are still poorly understood. In this study, we investigated the associations among gender, psychosocial variables, job-related stress and the presence of MS in a cohort of obese Caucasian workers.
   A total of 210 outpatients (142 women, 68 men) from an occupational medicine service was enrolled in the study. Age, BMI, waist circumference, fasting glucose, blood pressure, triglycerides and HDL cholesterol were collected to define MS. In addition, we evaluated eating behaviors, depressive symptoms, and work-related stress. Data analyses were performed with an artificial neural network algorithm called Auto Semantic Connectivity Map (AutoCM), using all available variables.
   MS was diagnosed in 54.4 and 33.1% of the men and women, respectively. AutoCM evidenced gender-specific clusters associated with the presence or absence of MS. Men with a moderate occupational physical activity, obesity, older age and higher levels of decision-making freedom at work were more likely to have a diagnosis of MS than women. Women with lower levels of decision-making freedom, and higher levels of psychological demands and social support at work had a lower incidence of MS but showed higher levels of binge eating and depressive symptomatology.
   We found a complex gender-related association between MS, psychosocial risk factors and occupational determinants. The use of these information in surveillance workplace programs might prevent the onset of MS and decrease the chance of negative long-term outcomes.
   Level V, observational study.
C1 [Vigna, Luisella; Conti, Diana M.; Agnelli, Gianna M.; Riboldi, Luciano] Fdn IRCCS Ca Granda, Clin Lavoro Luigi Devoto, Occupat Hlth Unit, Dept Prevent Med,Osped Maggiore Policlin, Via Francesco Sforza 35, I-20122 Milan, Italy.
   [Brunani, Amelia] S Giuseppe Hosp, Rehabil Med, IRCCS Ist Auxol Italiano, Verbania, Italy.
   [Brugnera, Agostino; Compare, Angelo] Univ Bergamo, Dept Human & Social Sci, Bergamo, Italy.
   [Grossi, Enzo] Villa Santa Maria Fdn, Tavernerio, Italy.
   [Tirelli, Amedea S.] Fdn IRCCS Ca Granda, Lab Clin Chem & Microbiol, Osped Maggiore Policlin, Milan, Italy.
   [Andersen, Lars L.] Natl Res Ctr Working Environm, Copenhagen, Denmark.
   [Andersen, Lars L.] Aalborg Univ, Dept Hlth Sci & Technol, Sport Sci, Aalborg, Denmark.
   [Buscema, Massimo] Semeion Res Ctr Sci Commun, Rome, Italy.
   [Buscema, Massimo] Univ Colorado, Denver, CO 80202 USA.
C3 IRCCS Ca Granda Ospedale Maggiore Policlinico; IRCCS Istituto Auxologico
   Italiano; University of Bergamo; IRCCS Ca Granda Ospedale Maggiore
   Policlinico; National Research Centre for the Working Environment;
   Aalborg University; University of Colorado System; University of
   Colorado Denver
RP Vigna, L (corresponding author), Fdn IRCCS Ca Granda, Clin Lavoro Luigi Devoto, Occupat Hlth Unit, Dept Prevent Med,Osped Maggiore Policlin, Via Francesco Sforza 35, I-20122 Milan, Italy.
EM luisella.vigna@policlinico.mi.it
RI Andersen, Lars/JAC-6887-2023; Amelia, Brunani/AAB-7725-2019; Grossi,
   Enzo/AAF-7765-2020
OI Vigna, Luisella/0000-0001-5014-721X; Buscema, Paolo
   Massimo/0000-0003-4356-0510; GROSSI, ENZO/0000-0003-0346-2684; Brugnera,
   Agostino/0000-0002-4066-4552
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NR 45
TC 19
Z9 21
U1 2
U2 21
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1124-4909
EI 1590-1262
J9 EAT WEIGHT DISORD-ST
JI Eat. Weight Disord.-Stud. Anorex.
PD FEB
PY 2019
VL 24
IS 1
BP 73
EP 81
DI 10.1007/s40519-018-0536-8
PG 9
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychiatry
GA HL2EE
UT WOS:000458515800010
PM 29987776
DA 2025-06-11
ER

PT S
AU Ahmadimanesh, M
   Abbaszadegan, MR
   Hedayati, N
   Yazdian-Robati, R
   Jamialahmadi, T
   Sahebkar, A
AF Ahmadimanesh, Mahnaz
   Abbaszadegan, Mohammad Reza
   Hedayati, Narges
   Yazdian-Robati, Rezvan
   Jamialahmadi, Tannaz
   Sahebkar, Amirhossein
BE Guest, PC
TI A Systematic Review on the Genotoxic Effects of Selective Serotonin
   Reuptake Inhibitors
SO REVIEWS ON NEW DRUG TARGETS IN AGE-RELATED DISORDERS, PT II
SE Advances in Experimental Medicine and Biology
LA English
DT Review; Book Chapter
DE Antidepressants; SSRIs; DNA damage; Genotoxicity
ID OXIDATIVE STRESS; DNA-DAMAGE; REPRODUCTIVE TOXICITY; FLUOXETINE;
   CITALOPRAM; SERTRALINE; INFLAMMATION; ANTIDEPRESSANTS; RECOMBINATION;
   ANTIBIOTICS
AB Depression is a mental disorder and a major public health concern affecting millions of people worldwide. It is a common disorder that has been associated with several medical comorbidities often linked with aging, such as dementia, type II diabetes, cardiovascular and cerebrovascular diseases, as well as metabolic syndrome. There are a variety of medications available for depression treatment. Selective serotonin reuptake inhibitors (SSRIs) are one of the antidepressant drug classes that are most widely used to treat depressive disorders and depressive symptoms in other diseases. Due to many contradictory findings on the adverse effects and toxicities of SSRIs (especially genotoxicities), we reviewed the genotoxic effects of these drugs. Based on the guidelines proposed in the PRISMA statement, we performed a systematic review by searching international electronic databases including PubMed, Scopus, Embase, and Web of Science to find the published documents on SSRIs and their genotoxic effects from January 1990 to November 2019. After the removal of 203 duplicate articles, 385 articles were screened and 167 articles met the inclusion criteria and qualified for evaluation of their full texts. After this, 26 articles were appropriate for final review. This revealed that the proportion of genotoxicities was highest for citalopram and fluoxetine, with a smaller proportion for sertraline. Limited documentations showed genotoxic and partial genotoxic effects for paroxetine and escitalopram, respectively. Although a number of studies have found genotoxic effects of SSRIs, there are also some factors including doses, duration of exposure, model of experiments, and the type of technique assay that may affect the results.
C1 [Ahmadimanesh, Mahnaz; Hedayati, Narges] Mashhad Univ Med Sci, Sch Pharm, Dept Pharmacodynam & Toxicol, Mashhad, Razavi Khorasan, Iran.
   [Ahmadimanesh, Mahnaz] Mashhad Univ Med Sci, Food & Drug Vice Presidency, Mashhad, Razavi Khorasan, Iran.
   [Abbaszadegan, Mohammad Reza] Mashhad Univ Med Sci, Immunol Res Ctr, Mashhad, Razavi Khorasan, Iran.
   [Abbaszadegan, Mohammad Reza] Mashhad Univ Med Sci, Fac Med Sci, Med Genet Res Ctr, Mashhad, Razavi Khorasan, Iran.
   [Yazdian-Robati, Rezvan] Mazandaran Univ Med Sci, Fac Med, Mol & Cell Biol Res Ctr, Sari, Iran.
   [Jamialahmadi, Tannaz] Islamic Azad Univ, Dept Food Sci & Technol, Quchan Branch, Quchan, Iran.
   [Jamialahmadi, Tannaz] Mashhad Univ Med Sci, Fac Med, Dept Nutr, Mashhad, Razavi Khorasan, Iran.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Biotechnol Res Ctr, Mashhad, Razavi Khorasan, Iran.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Neurogen Inflammat Res Ctr, Mashhad, Razavi Khorasan, Iran.
   [Sahebkar, Amirhossein] Polish Mothers Mem Hosp Res Inst PMMHRI, Mashhad, Razavi Khorasan, Iran.
C3 Mashhad University of Medical Sciences; Mashhad University of Medical
   Sciences; Mashhad University of Medical Sciences; Mashhad University of
   Medical Sciences; Mazandaran University of Medical Sciences; Islamic
   Azad University; Mashhad University of Medical Sciences; Mashhad
   University of Medical Sciences; Mashhad University of Medical Sciences
RP Yazdian-Robati, R (corresponding author), Mazandaran Univ Med Sci, Fac Med, Mol & Cell Biol Res Ctr, Sari, Iran.; Sahebkar, A (corresponding author), Mashhad Univ Med Sci, Pharmaceut Technol Inst, Biotechnol Res Ctr, Mashhad, Razavi Khorasan, Iran.; Sahebkar, A (corresponding author), Mashhad Univ Med Sci, Neurogen Inflammat Res Ctr, Mashhad, Razavi Khorasan, Iran.; Sahebkar, A (corresponding author), Polish Mothers Mem Hosp Res Inst PMMHRI, Mashhad, Razavi Khorasan, Iran.
EM R.yazdian@mazums.ac.ir
RI Yazdian-Robati, rezvan/AAM-2038-2021; Sahebkar, Amirhossein/B-5124-2018
OI Jami, Tannaz/0000-0001-9521-3153
FU Mazandaran University of Medical Sciences [6067]
FX Mazandaran University of Medical Sciences provided financial support of
   this study by Grant No. 6067.
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NR 53
TC 5
Z9 5
U1 0
U2 10
PU SPRINGER INTERNATIONAL PUBLISHING AG
PI CHAM
PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND
SN 0065-2598
EI 2214-8019
BN 978-3-030-55035-6; 978-3-030-55034-9
J9 ADV EXP MED BIOL
JI Adv.Exp.Med.Biol.
PY 2021
VL 1286
BP 115
EP 124
DI 10.1007/978-3-030-55035-6_8
D2 10.1007/978-3-030-55035-6
PG 10
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Book Citation Index – Science (BKCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA BR2MC
UT WOS:000637940600009
PM 33725349
DA 2025-06-11
ER

PT J
AU Kocakaya, H
   Songur, E
   Batmaz, S
   Çelikbas, Z
   Küçük, Ö
AF Kocakaya, Hanife
   Songur, Emrah
   Batmaz, Sedat
   Celikbas, Zekiye
   Kucuk, Onder
TI Impact of metabolic syndrome and clinical features on functioning in
   patients with bipolar disorder: a cross-sectional study
SO BRAZILIAN JOURNAL OF PSYCHIATRY
LA English
DT Article
DE Bipolar disorder; clinical factors; functionality; metabolic syndrome
ID TREATMENT OPTIMIZATION PROGRAM; QUALITY-OF-LIFE; RATING-SCALE; MANIA;
   RELIABILITY; IMPAIRMENT; SYMPTOMS; VALIDITY; OUTCOMES
AB Objective: The metabolic syndrome (MS) is highly prevalent among patients with bipolar disorder (BD), and may affect progression, functioning, and comorbid conditions in BD. The aim of this study was to investigate the effect of clinical variables and MS on overall functioning and specific areas of functioning in patients with BD.
   Methods: A total of 210 participants (140 participants with BD I and BD II in remission and 70 nonpsychiatric control subjects) were included. The investigators administered the Young Mania Rating Scale (YMRS), the Bipolar Depression Rating Scale (BDRS), the Global Assessment of Functioning Scale (GAF), and the Bipolar Disorder Functioning Scale (BDFS). The participants completed the Beck Depression Scale (BDS) and the Beck Anxiety Scale (BAS). MS was diagnosed according to the National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) criteria. Hierarchical regression analysis was used to investigate potential correlations of comorbid MS with clinical variables and level of functioning.
   Results: Level of functioning did not differ between patients with and without MS. However, there were significant correlations between the level of functioning subscales and the number of depressive episodes (p = 0.033), level of general functioning (p = 0.012), duration of illness (p = 0.012), BDS (p = 0.005), BDRS (p = 0.021), BAS total scores (p = 0.021), number of hypomanic episodes (p = 0.022), number of hospitalizations (p = 0.003), employment status (p = 0.032), and diagnosis of BD I (p = 0.007) and BD II (p = 0.044).
   Conclusion: Our findings suggest that clinical variables had a greater effect on functioning than MS in BD patients.
C1 [Kocakaya, Hanife; Kucuk, Onder] Dr Cevdet Aykan Mental Hlth & Dis Hosp, TR-60100 Center Merkez, Tokat, Turkey.
   [Songur, Emrah] Kecioren Educ & Res Hosp, Ankara, Turkey.
   [Batmaz, Sedat; Celikbas, Zekiye] Gaziosmanpasa Univ, Fac Med, Tokat, Turkey.
C3 Ankara Kecioren Training & Research Hospital; Tokat Gaziosmanpasa
   University
RP Kocakaya, H (corresponding author), Dr Cevdet Aykan Mental Hlth & Dis Hosp, TR-60100 Center Merkez, Tokat, Turkey.
EM drhanifekocakaya@gmail.com
RI Songur, Emrah/IAO-6490-2023; Batmaz, Sedat/A-2157-2019
OI Batmaz, Sedat/0000-0003-0585-2184; Songur, Emrah/0000-0003-4949-0154;
   KOCAKAYA, HANIFE/0000-0002-5907-3808
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NR 40
TC 2
Z9 2
U1 0
U2 9
PU ASSOC BRASILEIRA PSIQUIATRIA
PI SAO PAULO
PA SUBSCRIPTION DEPARTMENT, RUA PEDRO DE TOLEDO, 967 - CASA 01, SAO PAULO,
   SP 04039-032  A, BRAZIL
SN 1516-4446
EI 1809-452X
J9 BRAZ J PSYCHIAT
JI Braz. J. Psychiat.
PD JUL-AUG
PY 2020
VL 42
IS 4
BP 373
EP 381
DI 10.1590/1516-4446-2019-0622
PG 9
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA NE3FI
UT WOS:000562483100010
PM 32187318
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Jacobs, CA
   Mace, RA
   Greenberg, J
   Popok, PJ
   Reichman, M
   Lattermann, C
   Burris, JL
   Macklin, EA
   Vranceanu, AM
AF Jacobs, Cale A.
   Mace, Ryan A.
   Greenberg, Jonathan
   Popok, Paula J.
   Reichman, Mira
   Lattermann, Christian
   Burris, Jessica L.
   Macklin, Eric A.
   Vranceanu, Ana -Maria
TI Development of a mind body program for obese knee osteoarthritis
   patients with comorbid depression
SO CONTEMPORARY CLINICAL TRIALS COMMUNICATIONS
LA English
DT Article
DE Osteoarthritis; Depression; Obesity; Mind-body; Resiliency; Physical
   activity
ID QUALITY-OF-LIFE; PAIN CLINICAL-TRIALS; PHYSICAL-ACTIVITY; BIDIRECTIONAL
   ASSOCIATION; PSYCHOLOGICAL HEALTH; MUSCULOSKELETAL PAIN; REPLACEMENT
   SURGERY; METABOLIC SYNDROME; CARTILAGE ATROPHY; FEAR-AVOIDANCE
AB Knee osteoarthritis (OA) is the most common joint disorder in the U.S. and a leading cause of disability. Depression and obesity are highly comorbid among knee OA patients, and the combination of obesity and depression is associated with decreased physical activity, higher pain and disability, and more rapid cartilage degradation. Depression, obesity and OA exacerbate one another and share a common pathophysiology involving systemic inflammation and pro-inflammatory cytokines, reflecting a complex mind-body interaction. Current treatments for knee OA offer little to no benefit over placebo, and do not emphasize mind-body practices or physical activity to target the underlying pathophysiology. Mind-body interventions to lessen depressive symptoms and increase physical activity offer the ability to target biological, mechanical and psychological mechanisms of OA progression. Our long-term goals are to evaluate the mechanisms by which the Relaxation Response Resiliency Program (3RP) delivered via secure telehealth, and adapted for patients with depression, obesity and knee OA (GetActive-OA) promotes increases in physical activity and improved knee health. We hypothesize that the synergistic interaction between mindfulness, adaptive thinking, positive psychology and healthy living skills of the GetActive-OA will slow the progression of symptomatic knee OA by reducing proinflammatory cytokine expression and promoting optimal mechanical loading of the cartilage. Here we present the protocol for a mixed methods study that will adapt the 3RP for the needs of knee OA patients with depression and obesity with a focus on increasing physical activity (GetActive-OA), and iteratively maximize the feasibility, credibility and acceptability of the programs and research procedures.
C1 [Jacobs, Cale A.] Univ Kentucky, Dept Orthopaed Surg & Sports Med, 740 S Limestone,Suite K401, Lexington, KY 40536 USA.
   [Mace, Ryan A.; Greenberg, Jonathan; Popok, Paula J.; Reichman, Mira; Macklin, Eric A.; Vranceanu, Ana -Maria] Massachusetts Gen Hosp, Dept Psychiat, Integrated Brain Hlth Clin & Res Program, 1 Bowdoin Sq,1st Floor,Suite 100, Boston, MA 02114 USA.
   [Lattermann, Christian] Brigham & Womens Hosp, Dept Orthoped Surg, 850 Boylston St, Chestnut Hill, MA 02467 USA.
   [Burris, Jessica L.] Univ Kentucky, Dept Psychol, 207K Kastle Hall, Lexington, KY 40506 USA.
C3 University of Kentucky; Harvard University; Harvard University Medical
   Affiliates; Massachusetts General Hospital; Harvard University; Harvard
   University Medical Affiliates; Brigham & Women's Hospital; University of
   Kentucky
RP Jacobs, CA (corresponding author), 740 S Limestone,Suite K401, Lexington, KY 40536 USA.
EM cale.jacobs@uky.edu; rmace@mgh.harvard.edu; jgreenberg5@mgh.harvard.edu;
   ppopok@mgh.harvard.edu; mreichman@mgh.harvard.edu;
   clattermann@bwh.harvard.edu; jessica.burris@uky.edu;
   emacklin@mgh.harvard.edu; avranceanu@mgh.harvard.edu
RI Macklin, Eric/E-2955-2013; Vranceanu, Ana-Maria/AAF-4429-2020; Rodeo,
   Scott/A-7995-2016
OI Mace, Ryan/0000-0001-5738-8606; Popok, Paula/0000-0003-2691-1761;
   Greenberg, Jonathan/0000-0002-4875-2207; Jacobs,
   Cale/0000-0002-9300-5550; Reichman, Mira/0000-0002-4338-6674
FU National Center for Complementary and Integrative Health (NCCIH) [R34
   AT010370-01A1]
FX This study is funded by a clinical trial grant awarded to CAJ and AMV by
   the National Center for Complementary and Integrative Health (NCCIH; R34
   AT010370-01A1). The sponsor was not involved in the review or approval
   of this manuscript for publication.
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NR 112
TC 10
Z9 11
U1 2
U2 9
PU ELSEVIER INC
PI SAN DIEGO
PA 525 B STREET, STE 1900, SAN DIEGO, CA 92101-4495 USA
EI 2451-8654
J9 CONT CLIN TRIAL COMM
JI Contemp. Clin. Trials Commun.
PD MAR
PY 2021
VL 21
AR 100720
DI 10.1016/j.conctc.2021.100720
EA FEB 2021
PG 10
WC Medicine, Research & Experimental
WE Emerging Sources Citation Index (ESCI)
SC Research & Experimental Medicine
GA RG2XY
UT WOS:000635408400011
PM 33553798
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Häusl, AS
   Balsevich, G
   Gassen, NC
   Schmidt, MV
AF Haeusl, Alexander S.
   Balsevich, Georgia
   Gassen, Nils C.
   Schmidt, Mathias V.
TI Focus on FKBP51: A molecular link between stress and metabolic disorders
SO MOLECULAR METABOLISM
LA English
DT Review
DE FKBP51; SAFit2; Adipogensis; Glucose uptake; Obesity; Stress; Type 2
   diabetes
ID BROWN ADIPOSE-TISSUE; KINASE-MEDIATED PHOSPHORYLATION; NERVOUS-SYSTEM
   CONTROL; DIET-INDUCED OBESITY; PROTEIN-KINASE; GLUCOCORTICOID-RECEPTOR;
   FK506-BINDING PROTEIN; IMMUNOPHILIN FKBP51; INSULIN-RESISTANCE;
   FOOD-INTAKE
AB Background: Obesity, Type 2 diabetes (T2D) as well as stress-related disorders are rising public health threats and major burdens for modern society. Chronic stress and depression are highly associated with symptoms of the metabolic syndrome, but the molecular link is still not fully understood. Furthermore, therapies tackling these biological disorders are still lacking. The identification of shared molecular targets underlying both pathophysiologies may lead to the development of new treatments. The FK506 binding protein 51 (FKBP51) has recently been identified as a promising therapeutic target for stress-related psychiatric disorders and obesity-related metabolic outcomes.
   Scope of the review: The aim of this review is to summarize current evidence of in vitro, preclinical, and human studies on the stress responsive protein FKBP51, focusing on its newly discovered role in metabolism. Also, we highlight the therapeutic potential of FKBP51 as a new treatment target for symptoms of the metabolic syndrome.
   Major conclusions: We conclude the review by emphasizing missing knowledge gaps that remain and future research opportunities needed to implement FKBP51 as a drug target for stress-related obesity or T2D. (C) 2019 The Authors. Published by Elsevier GmbH.
C1 [Haeusl, Alexander S.; Schmidt, Mathias V.] Max Planck Inst Psychiat, Res Grp Neurobiol Stress Resilience, D-80804 Munich, Germany.
   [Balsevich, Georgia] Univ Calgary, Hotchkiss Brain Inst, 3330 Hosp Dr NW, Calgary, AB T2N 4N1, Canada.
   [Gassen, Nils C.] Univ Bonn, Bonn Clin Ctr, Dept Psychiat & Psychotherapy, D-53127 Bonn, Germany.
   [Gassen, Nils C.] Max Planck Inst Psychiat, Dept Translat Res Psychiat, D-80804 Munich, Germany.
C3 Max Planck Society; University of Calgary; University of Bonn; Max
   Planck Society
RP Häusl, AS; Schmidt, MV (corresponding author), Kraepelinstr 2-10, D-80804 Munich, Germany.
EM alexander.haeusl@biophyll.com; mschmidt@psych.mpg.de
RI Gassen, Nils/AAZ-2504-2021
FU BioM M4 award "PROCERA" of the Bavarian State Ministry; "OptiMD" grant
   of the Federal Ministry of Education and Research [01EE1401D]; "GUTMOM"
   grant of the Federal Ministry of Education and Research [01EA1805]
FX The current work was supported by the BioM M4 award "PROCERA" of the
   Bavarian State Ministry (Schmidt), the "OptiMD" grant of the Federal
   Ministry of Education and Research (01EE1401D; Schmidt) and the "GUTMOM"
   grant of the Federal Ministry of Education and Research (01EA1805;
   Schmidt).
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NR 135
TC 47
Z9 50
U1 0
U2 7
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2212-8778
J9 MOL METAB
JI Mol. Metab.
PD NOV
PY 2019
VL 29
BP 170
EP 181
DI 10.1016/j.molmet.2019.09.003
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA JH3VD
UT WOS:000492695200015
PM 31668388
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Hruska, V
   Shivappa, N
   Hébert, JR
   Duncan, AM
   Haines, J
   Ma, DWL
AF Hruska, Valerie
   Shivappa, Nitin
   Hebert, James R.
   Duncan, Alison M.
   Haines, Jess
   Ma, David W. L.
TI Associations between Family-Based Stress and Dietary Inflammatory
   Potential among Families with Preschool-Aged Children
SO NUTRIENTS
LA English
DT Article
DE dietary inflammatory index; inflammation; stress; mental health; family;
   health behaviour; diet quality; disease prevention
ID MEDITERRANEAN DIET; METABOLIC SYNDROME; MATERNAL STRESS; INDEX SCORES;
   RISK; FOOD; METAANALYSIS; MOTHERS; ENVIRONMENT; DEPRESSION
AB Chronic stress is known to influence dietary choices, and stressed families often report poorer diet quality; however, little is known about how family-based stress is linked with dietary patterns that promote inflammation. This study investigated associations between family-based stress and the inflammatory potential of the diet among preschool-aged children and their parents. Parents (n = 212 mothers, n = 146 fathers) and children (n = 130 girls, n = 123 boys; aged 18 months to 5 years) from 241 families participating in the Guelph Family Health Study were included in the analyses. Parents reported levels of parenting distress, depressive symptoms, household chaos, and family functioning. The inflammatory potential of parents' and children's diets was quantified using the Dietary Inflammatory Index (DII(R)), adjusted for total energy intake (i.e., the E-DIITM). E-DII scores were regressed onto family stress using generalized estimating equations to account for shared variance among family clusters. Compared to those in homes with low chaos, parents in chaotic homes had significantly more proinflammatory dietary profiles (beta = 0.973; 95% CI: 0.321, 1.624, p = 0.003). Similarly, compared to those in well-functioning families, parents in dysfunctional families had significantly more proinflammatory dietary profiles (beta = 0.967; 95% CI: 0.173, 1.761, p = 0.02). No significant associations were found between parents' E-DII scores and parenting distress or depressive symptoms, nor were any associations found for children's E-DII scores. Results were not found to differ between males and females. Parents in chaotic or dysfunctional family environments may be at increased risk of chronic disease due to proinflammatory dietary profiles. Children's dietary inflammatory profiles were not directly associated with family stress; however, indirect connections through family food-related behaviours may exist. Future research should prioritize elucidating these mechanisms.
C1 [Hruska, Valerie; Duncan, Alison M.; Ma, David W. L.] Univ Guelph, Dept Human Hlth & Nutr Sci, Guelph, ON N1G 2W1, Canada.
   [Shivappa, Nitin; Hebert, James R.] Univ South Carolina, Canc Prevent & Control Program, Columbia, SC 29208 USA.
   [Shivappa, Nitin; Hebert, James R.] Univ South Carolina, Arnold Sch Publ Hlth, Dept Epidemiol & Biostat, Columbia, SC 29208 USA.
   [Shivappa, Nitin; Hebert, James R.] Connecting Hlth Innovat LLC, Dept Nutr, Columbia, SC 29201 USA.
   [Haines, Jess] Univ Guelph, Dept Family Relat & Appl Nutr, Guelph, ON N1G 2W1, Canada.
C3 University of Guelph; University of South Carolina System; University of
   South Carolina Columbia; University of South Carolina System; University
   of South Carolina Columbia; Connecting Health Innovations LLC;
   University of Guelph
RP Ma, DWL (corresponding author), Univ Guelph, Dept Human Hlth & Nutr Sci, Guelph, ON N1G 2W1, Canada.
EM vhruska@uoguelph.ca; shivappa@email.sc.edu; JHEBERT@mailbox.sc.edu;
   amduncan@uoguelph.ca; jhaines@uoguelph.ca; davidma@uoguelph.ca
RI Hebert, James/IUO-5628-2023; Shivappa, Nitin/X-2215-2018
OI Hruska, Valerie/0000-0001-8282-5839; Ma, David/0000-0002-1165-5972
FU Canadian Institutes of Health Research
FX This research was funded by the Canadian Institutes of Health Research.
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NR 57
TC 3
Z9 4
U1 1
U2 2
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD MAY
PY 2021
VL 13
IS 5
AR 1464
DI 10.3390/nu13051464
PG 13
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nutrition & Dietetics
GA ST3HZ
UT WOS:000662340400001
PM 33925798
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Décarie-Spain, L
   Sharma, S
   Hryhorczuk, C
   Issa-Garcia, V
   Barker, PA
   Arbour, N
   Alquier, T
   Fulton, S
AF Decarie-Spain, Lea
   Sharma, Sandeep
   Hryhorczuk, Cecile
   Issa-Garcia, Victor
   Barker, Philip A.
   Arbour, Nathalie
   Alquier, Thierry
   Fulton, Stephanie
TI Nucleus accumbens inflammation mediates anxiodepressive behavior and
   compulsive sucrose seeking elicited by saturated dietary fat
SO MOLECULAR METABOLISM
LA English
DT Article
DE Diet-induced obesity; Dietary fatty acids; Nuclear factor kappa-b;
   Neuroinflammation; Depression; Anxiety; Food reward
ID FACTOR-KAPPA-B; PITUITARY-ADRENAL AXIS; C-REACTIVE PROTEIN; DEPRESSIVE
   SYMPTOMS; METABOLIC SYNDROME; INTERFERON-GAMMA; SOCIAL DEFEAT;
   OLEIC-ACID; OBESITY; STRESS
AB Objective: The incidence of depression is significantly compounded by obesity. Obesity arising from excessive intake of high-fat food provokes anxiodepressive behavior and elicits molecular adaptations in the nucleus accumbens (NAc), a region well-implicated in the hedonic deficits associated with depression and in the control of food-motivated behavior. To determine the etiology of diet-induced depression, we studied the impact of different dietary lipids on anxiodepressive behavior and metabolic and immune outcomes and the contribution of NAc immune activity.
   Methods: Adult C57Bl/6 mice were subjected to isocaloric high-fat/high-sucrose diets (HFD), enriched in either saturated or monounsaturated fat, or a control low-fat diet (LFD). Metabolic responses, anxiodepressive behavior, and plasma and NAc inflammatory markers were assessed after 12 weeks. In separate experiments, an adenoviral construct inhibiting IKK beta, an upstream component of the nuclear factor kappa-b (NFk beta) pathway, was a priori injected into the NAc.
   Results: Both HFDs resulted in obesity and hyperleptinemia; however, the saturated HFD uniquely triggered anxiety-like behavior, behavioral despair, hyperinsulinemia, glucose intolerance, peripheral inflammation, and multiple pro-inflammatory signs in the NAc, including reactive gliosis, increased expression of cytokines, antigen-presenting markers and NF kappa B transcriptional activity. Selective NAc IKK beta inhibition reversed the upregulated expression of inflammatory markers, prevented anxiodepressive behavior and blunted compulsive sucrose-seeking in mice fed the saturated HFD.
   Conclusions: Metabolic inflammation and NF kappa B-mediated neuroinflammatory responses in the NAc contribute to the expression of anxiodepressive behavior and heightened food cravings caused by a diet high in saturated fat and sugar. (C) 2018 The Authors. Published by Elsevier GmbH.
C1 [Decarie-Spain, Lea; Sharma, Sandeep; Hryhorczuk, Cecile; Issa-Garcia, Victor; Arbour, Nathalie; Alquier, Thierry; Fulton, Stephanie] Univ Montreal, CHUM, Ctr Rech, Montreal, PQ, Canada.
   [Decarie-Spain, Lea; Sharma, Sandeep; Hryhorczuk, Cecile; Issa-Garcia, Victor; Alquier, Thierry; Fulton, Stephanie] Univ Montreal, Montreal Diabet Res Ctr, Montreal, PQ, Canada.
   [Decarie-Spain, Lea; Arbour, Nathalie] Univ Montreal, Dept Neurosci, Montreal, PQ, Canada.
   [Sharma, Sandeep; Fulton, Stephanie] Univ Montreal, Dept Nutr, Montreal, PQ, Canada.
   [Alquier, Thierry] Univ Montreal, Dept Med, Montreal, PQ, Canada.
   [Barker, Philip A.] Univ British Columbia, Dept Biol, Vancouver, BC, Canada.
C3 Universite de Montreal; Universite de Montreal; Universite de Montreal;
   Universite de Montreal; Universite de Montreal; University of British
   Columbia
RP Fulton, S (corresponding author), CRCHUM, 900 St Denis,R08-428, Montreal, PQ H2X 0A9, Canada.; Fulton, S (corresponding author), Montreal Diabet Res Ctr, 900 St Denis,R08-428, Montreal, PQ H2X 0A9, Canada.
EM stephanie.fulton@umontreal.ca
RI Sharma, Sandeep/AAU-7050-2021; Alquier, Thierry/Z-1917-2019
OI Issa-Garcia, Victor/0000-0002-9596-988X; Sharma,
   Sandeep/0000-0002-9680-7460; Arbour, Nathalie/0000-0002-3718-1584;
   Alquier, Thierry/0000-0001-8171-802X
FU MDRC/Sunlife grant; CIHR [MOP115042]; FRQS; CIHR Neuroinflammation
   Training Program; MITACS Summer Internship; FRQS Salary Award; CIHR New
   Investigator Award
FX This work was supported by a MDRC/Sunlife grant to SF and a CIHR grant
   (MOP115042). LDS was supported by a doctoral fellowship from FRQS, SS by
   a postdoctoral fellowship from the CIHR Neuroinflammation Training
   Program, VIG by a MITACS Summer Internship, TA by a FRQS Salary Award
   and SF (2013-18) and NA (2012-2017) a CIHR New Investigator Award. The
   authors thank the Rodent Phenotyping Platform at CRCHUM for measures in
   metabolic cages and plasma analysis of insulin and leptin.
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NR 78
TC 76
Z9 85
U1 0
U2 14
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2212-8778
J9 MOL METAB
JI Mol. Metab.
PD APR
PY 2018
VL 10
BP 1
EP 13
DI 10.1016/j.molmet.2018.01.018
PG 13
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism
GA GN9SM
UT WOS:000439548000001
PM 29454579
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Shomaker, LB
   Tanofsky-Kraff, M
   Young-Hyman, D
   Han, JC
   Yanoff, LB
   Brady, SM
   Yanovski, SZ
   Yanovski, JA
AF Shomaker, Lauren B.
   Tanofsky-Kraff, Marian
   Young-Hyman, Deborah
   Han, Joan C.
   Yanoff, Lisa B.
   Brady, Sheila M.
   Yanovski, Susan Z.
   Yanovski, Jack A.
TI Psychological symptoms and insulin sensitivity in adolescents
SO PEDIATRIC DIABETES
LA English
DT Article
DE adolescents; children; depression; general psychopathology; insulin
   sensitivity
ID METABOLIC SYNDROME; DEPRESSIVE SYMPTOMS; CARDIOVASCULAR-DISEASE;
   GLUCOSE-METABOLISM; PUBERTAL CHANGES; RISK-FACTORS; RESISTANCE;
   CHILDREN; PREVALENCE; SECRETION
AB Purpose: Symptoms of psychological distress have been linked to low insulin sensitivity in adults; however, little is known about this relationship in pediatric samples. We therefore examined symptoms of depression and anxiety in relation to insulin sensitivity in adolescents.
   Methods: Participants were 136 non-treatment-seeking, healthy adolescents (53.2% female) of all weight strata (BMI-z = 1.08 +/- 1.08) between the ages of 12 and 18 years (M = 15.16,SD = 1.55). Adolescents completed questionnaire measures assessing depression and anxiety symptoms. Fasting blood samples for serum insulin and plasma glucose were obtained to estimate insulin sensitivity with the quantitative insulin sensitivity check index. Fat mass and fat-free mass were measured with air displacement plethysmography or dual-energy X-ray absorptiometry.
   Results: Depressive symptoms were associated with higher fasting insulin and decreased insulin sensitivity even after controlling for fat mass, fat-free mass, height, age, pubertal status, race, and sex (p < 0.01).
   Conclusions: As has been described for adults, depressive symptoms are associated with low insulin sensitivity among healthy adolescents. Further experimental and prospective studies are required to determine the directionality of this link.
C1 [Yanovski, Jack A.] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Unit Growth & Obes, Program Dev Endocrinol, Dept Hlth & Human Serv,Hatfield Clin Res Ctr,NIH, Bethesda, MD 20892 USA.
   [Shomaker, Lauren B.; Tanofsky-Kraff, Marian] Uniformed Serv Univ Hlth Sci, Dept Med & Clin Psychol, Bethesda, MD 20814 USA.
   [Yanovski, Susan Z.] NIDDK, Div Digest Dis & Nutr, DHHS, NIH, Bethesda, MD 20892 USA.
C3 National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver
   National Institute of Child Health & Human Development (NICHD);
   Uniformed Services University of the Health Sciences - USA; National
   Institutes of Health (NIH) - USA; NIH National Institute of Diabetes &
   Digestive & Kidney Diseases (NIDDK)
RP Yanovski, JA (corresponding author), Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Unit Growth & Obes, Program Dev Endocrinol, Dept Hlth & Human Serv,Hatfield Clin Res Ctr,NIH, 9000 Rockville Pike,Room 1E-3330,MSC 1103, Bethesda, MD 20892 USA.
EM jy15i@nih.gov
OI Han, Joan/0000-0003-4252-2678; Yanovski, Jack/0000-0001-8542-1637
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NR 41
TC 43
Z9 50
U1 0
U2 4
PU WILEY-HINDAWI
PI LONDON
PA ADAM HOUSE, 3RD FL, 1 FITZROY SQ, LONDON, WIT 5HE, ENGLAND
SN 1399-543X
EI 1399-5448
J9 PEDIATR DIABETES
JI Pediatr. Diabetes
PD SEP
PY 2010
VL 11
IS 6
BP 417
EP 423
DI 10.1111/j.1399-5448.2009.00606.x
PG 7
WC Endocrinology & Metabolism; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Pediatrics
GA 643HG
UT WOS:000281285600008
PM 19912553
OA Green Accepted, gold
DA 2025-06-11
ER

PT J
AU Sivakoti, K
AF Sivakoti, Kirti
TI Adolescent Metabolic Screening
SO PRIMARY CARE
LA English
DT Article
DE Metabolic screening; Obesity; Dyslipidemia; Adolescents
ID CHILDREN
AB In pediatrics, many unanswered questions remain regarding the definition and utility of the diagnosis of MetS. Therefore, it is prudent to transition from utilizing MetS as an organizational framework to concentrating on cardiometabolic risk factors, many of which tend to cluster and exhibit strong associations with obesity. Clinicians should refrain from fixating on precise thresholds for cardiometabolic risk factors within the myriad MetS definitions, as these risks manifest along a continuous spectrum and are best understood in the broader context of the child's overall health. Current guidelines by the US Preventive Services Task Force support screening for obesity in children and adolescents aged 6 years and older using age-adjusted and sex-adjusted BMI percentiles, coupled with comprehensive, intensive behavioral interventions. While these interventions show moderate benefits in improving weight status, pharmacotherapy interventions such as metformin and orlistat have uncertain clinical significance and moderate harms.20 The identification of children harboring multiple risk factors empowers clinicians to allocate their most intensive interventions to those children and adolescents in need of risk reduction. Enhanced awareness of concurrent conditions like NAFLD, mental health disorders, PCOS, and OSA equips clinicians to address these issues effectively and make apt referrals to specialists when deemed necessary.5
C1 [Sivakoti, Kirti] Univ Utah, Div Gen Pediat, 295 Chipeta Way,Suite 14, Salt Lake City, UT 84108 USA.
   [Sivakoti, Kirti] Primary Childrens Ctr, Pediat Auton & Unexplained Symptoms Evidence Based, Salt Lake City, UT 84113 USA.
C3 Utah System of Higher Education; University of Utah
RP Sivakoti, K (corresponding author), Univ Utah, Div Gen Pediat, 295 Chipeta Way,Suite 14, Salt Lake City, UT 84108 USA.; Sivakoti, K (corresponding author), Primary Childrens Ctr, Pediat Auton & Unexplained Symptoms Evidence Based, Salt Lake City, UT 84113 USA.
EM Kirti.sivakoti@hsc.utah.edu
RI Sivakoti, Kirti/LTY-7418-2024
CR [Anonymous], 2011, OBESITY OVERWEIGHT F
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NR 20
TC 1
Z9 1
U1 0
U2 0
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0095-4543
EI 1558-299X
J9 PRIMARY CARE
JI Primary Care
PD DEC
PY 2024
VL 51
IS 4
BP 603
EP 611
DI 10.1016/j.pop.2024.05.011
EA OCT 2024
PG 9
WC Primary Health Care; Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA K4O3K
UT WOS:001343680500001
PM 39448097
DA 2025-06-11
ER

PT J
AU Etchegoyen, M
   Nobile, MH
   Baez, F
   Posesorski, B
   González, J
   Lago, N
   Milei, J
   Otero-Losada, M
AF Etchegoyen, Melisa
   Nobile, Mariana H.
   Baez, Francisco
   Posesorski, Barbara
   Gonzalez, Julian
   Lago, Nestor
   Milei, Jose
   Otero-Losada, Matilde
TI Metabolic Syndrome and Neuroprotection
SO FRONTIERS IN NEUROSCIENCE
LA English
DT Review
DE metabolic syndrome X; neuroprotection; hypoxia; brain; oxidative stress;
   antioxidants
ID ALPHA-LIPOIC ACID; ALDOSE REDUCTASE INHIBITOR; DIABETIC PERIPHERAL
   NEUROPATHY; PROTEIN-KINASE-C; NF-KAPPA-B; OXIDATIVE STRESS;
   ALZHEIMERS-DISEASE; ANTIOXIDANT DEFENSE; MITOCHONDRIAL DYSFUNCTION;
   COGNITIVE IMPAIRMENT
AB Introduction: Over the years the prevalence of metabolic syndrome (MetS) has drastically increased in developing countries as a major byproduct of industrialization. Many factors, such as the consumption of high-calorie diets and a sedentary lifestyle, bolster the spread of this disorder. Undoubtedly, the massive and still increasing incidence of MetS places this epidemic as an important public health issue. Hereon we revisit another outlook of MetS beyond its classical association with cardiovascular disease (CVD) and Diabetes Mellitus Type 2 (DM2), for MetS also poses a risk factor for the nervous tissue and threatens neuronal function. First, we revise a few essential concepts of MetS pathophysiology. Second, we explore some neuroprotective approaches in MetS pertaining brain hypoxia. The articles chosen for this review range from the years 1989 until 2017; the selection criteria was based on those providing data and exploratory information on MetS as well as those that studied innovative therapeutic approaches.
   Pathophysiology: The characteristically impaired metabolic pathways of MetS lead to hyperglycemia, insulin resistance (IR), inflammation, and hypoxia, all closely associated with an overall pro-oxidative status. Oxidative stress is well-known to cause the wreckage of cellular structures and tissue architecture. Alteration of the redox homeostasis and oxidative stress alter the macromolecular array of DNA, lipids, and proteins, in turn disrupting the biochemical pathways necessary for normal cell function.
   Neuroprotection: Different neuroprotective strategies are discussed involving lifestyle changes, medication aimed to mitigate MetS cardinal symptoms, and treatments targeted toward reducing oxidative stress. It is well-known that the routine practice of physical exercise, aerobic activity in particular, and a complete and well-balanced nutrition are key factors to prevent MetS. Nevertheless, pharmacological control of MetS as a whole and pertaining hypertension, dyslipidemia, and endothelial injury contribute to neuronal health improvement.
   Conclusion: The development of MetS has risen as a risk factor for neurological disorders. The therapeutic strategies include multidisciplinary approaches directed to address different pathological pathways all in concert.
C1 [Etchegoyen, Melisa; Nobile, Mariana H.; Baez, Francisco; Posesorski, Barbara; Gonzalez, Julian; Milei, Jose; Otero-Losada, Matilde] Univ Buenos Aires, Sch Med, Inst Cardiol Res, Buenos Aires, DF, Argentina.
   [Lago, Nestor] Univ Buenos Aires, CONICET, Sch Med, Inst Cardiovasc Pathophysiol, Buenos Aires, DF, Argentina.
C3 University of Buenos Aires; Consejo Nacional de Investigaciones
   Cientificas y Tecnicas (CONICET); University of Buenos Aires; Instituto
   Cardiovascular de Buenos Aires (ICBA)
RP Etchegoyen, M; Otero-Losada, M (corresponding author), Univ Buenos Aires, Sch Med, Inst Cardiol Res, Buenos Aires, DF, Argentina.
EM mberisso@gmail.com; molly1063@gmail.com
RI Otero-Losada, Matilde/J-3050-2019; Stefanadis,
   Christodoulos/ABH-2232-2020
OI Stefanadis, Christodoulos/0000-0001-5974-6454; Lago,
   Nestor/0000-0002-7633-8687
FU National Research Council Argentina, CONICET [PIP 11220150100319]
FX This work was supported by PIP 11220150100319 from the National Research
   Council Argentina, CONICET granted to Matilde OTERO-LOSADA.
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NR 199
TC 32
Z9 34
U1 0
U2 10
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1662-453X
J9 FRONT NEUROSCI-SWITZ
JI Front. Neurosci.
PD APR 20
PY 2018
VL 12
AR 196
DI 10.3389/fnins.2018.00196
PG 14
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA GD4ZZ
UT WOS:000430514600001
PM 29731703
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Aurangabadkar, SJ
AF Aurangabadkar, Sanjeev J.
TI Comorbidities in psoriasis
SO INDIAN JOURNAL OF DERMATOLOGY VENEREOLOGY & LEPROLOGY
LA English
DT Article
DE Cardiovascular disease; metabolic syndrome; psoriasis; comorbidities
ID METABOLIC SYNDROME; LIVER-DISEASE; RISK; PREVALENCE; DEPRESSION;
   OBESITY; ATHEROSCLEROSIS; RECOMMENDATIONS; EPIDEMIOLOGY; INFLAMMATION
AB Moderate to severe psoriasis is associated with concomitant diseases that may have a significant impact on patients. It is necessary for the treating physician to recognize these concomitant diseases, known as comorbidities, early as they influence the management options. Important comorbidities are psoriatic arthritis, metabolic syndrome, Crohn's disease, depression, and cancer. Patients with severe psoriasis may be at an increased risk for myocardial infarction and this subgroup of patients tends to have a reduced life expectancy. The presence of co-morbid diseases is associated with an increase in concomitant medication, some of which may worsen psoriasis; conversely, systemic treatment of psoriasis with certain drugs may impact the co-morbid conditions. As dermatologists are the primary health-care providers for psoriasis, adequate knowledge of comorbidities helps in choosing the appropriate therapy as well as timely intervention.
C1 [Aurangabadkar, Sanjeev J.] Skin & Laser Clin, Dept Dermatol, Hyderabad, Andhra Pradesh, India.
RP Aurangabadkar, SJ (corresponding author), Skin & Laser Clin, 1st Floor, Hyderabad, Andhra Pradesh, India.
EM sanjeev.aurangabadkar@gmail.com
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NR 55
TC 27
Z9 34
U1 1
U2 5
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, 400059, INDIA
SN 0378-6323
EI 0973-3922
J9 INDIAN J DERMATOL VE
JI Indian J. Dermatol. Venereol. Leprol.
PD JUL
PY 2013
VL 79
SU 1
BP S10
EP S17
DI 10.4103/0378-6323.115506
PG 8
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 207QI
UT WOS:000323617000002
PM 23974690
OA gold
DA 2025-06-11
ER

PT J
AU Violanti, JM
   Charles, LE
   McCanlies, E
   Hartley, TA
   Baughman, P
   Andrew, ME
   Fekedulegn, D
   Ma, CC
   Mnatsakanova, A
   Burchfiel, CM
AF Violanti, John M.
   Charles, Luenda E.
   McCanlies, Erin
   Hartley, Tara A.
   Baughman, Penelope
   Andrew, Michael E.
   Fekedulegn, Desta
   Ma, Claudia C.
   Mnatsakanova, Anna
   Burchfiel, Cecil M.
TI Police stressors and health: a state-of-the-art review
SO POLICING-AN INTERNATIONAL JOURNAL OF POLICE STRATEGIES & MANAGEMENT
LA English
DT Review
DE Resilience; Psychological health; Post-traumatic stress disorder; Law
   enforcement; Traumatic events; Work schedules
ID POSTTRAUMATIC-STRESS; SHIFT-WORK; RISK-FACTORS; PERCEIVED STRESS; SLEEP
   DISORDERS; PTSD SYMPTOMS; CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME;
   LIFE EVENTS; OFFICERS
AB Purpose - The purpose of this paper is to provide a state-of-the-art review on the topic of police stressors and associated health outcomes. Recent empirical research is reviewed in the areas of workplace stress, shift work, traumatic stress, and health. The authors provide a comprehensive table outlining occupational exposures and related health effects in police officers.
   Design/methodology/approach - A review of recent empirical research on police stress and untoward psychological and physiological health outcomes in police officers.
   Findings - The results offer a conceptual idea of the empirical associations between stressful workplace exposures and their impact on the mental and physical well-being of officers.
   Research limitations/implications - A key limitation observed in prior research is the cross-sectional study design; however, this serves as a motivator for researchers to explore these associations utilizing a longitudinal study design that will help determine causality.
   Originality/value - This review provides empirical evidence of both mental and physical outcomes associated with police stress and the processes involved in both. Research findings presented in this paper are based on sound psychological and medical evidence among police officers
C1 [Violanti, John M.] SUNY Buffalo, Buffalo, NY USA.
   [Charles, Luenda E.; McCanlies, Erin; Hartley, Tara A.; Baughman, Penelope; Andrew, Michael E.; Fekedulegn, Desta; Ma, Claudia C.; Mnatsakanova, Anna; Burchfiel, Cecil M.] NIOSH, Hlth Effects Lab, Morgantown, WV 26505 USA.
C3 State University of New York (SUNY) System; University at Buffalo, SUNY;
   Centers for Disease Control & Prevention - USA; National Institute for
   Occupational Safety & Health (NIOSH)
RP Charles, LE (corresponding author), NIOSH, Hlth Effects Lab, Morgantown, WV 26505 USA.
EM violanti@buffalo.edu
RI Charles, Luenda/H-6008-2011
FU National Institute for Occupational Safety and Health (NIOSH)
   [200-2003-01580]
FX This work was supported by the National Institute for Occupational
   Safety and Health (NIOSH), Contract No. 200-2003-01580. The findings and
   conclusions in this paper are those of the authors and do not
   necessarily represent the views of the NIOSH.
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NR 97
TC 111
Z9 112
U1 1
U2 45
PU EMERALD GROUP PUBLISHING LTD
PI Leeds
PA Floor 5, Northspring 21-23 Wellington Street, Leeds, W YORKSHIRE,
   ENGLAND
SN 1363-951X
EI 1758-695X
J9 POLICING
JI Policing-An Int J Police Strategies & Manag.
PY 2017
VL 40
IS 4
BP 642
EP 656
DI 10.1108/PIJPSM-06-2016-0097
PG 15
WC Criminology & Penology
WE Social Science Citation Index (SSCI)
SC Criminology & Penology
GA FM1PV
UT WOS:000414751900001
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Martin, DA
   Hook, J
   Kim, SW
   Larkey, L
   Lee, RE
AF Martin, Danielle A.
   Hook, Jane
   Kim, Sunny Wonsun
   Larkey, Linda
   Lee, Rebecca E.
TI Mind-body therapy for cardiometabolic risk in US middle-aged Black
   adults: a scoping review
SO FRONTIERS IN PUBLIC HEALTH
LA English
DT Review
DE scoping review; mind-body therapy; cardiometabolic risk factors;
   middle-aged black adults; psychosocial stress
ID AFRICAN-AMERICAN WOMEN; CARDIOVASCULAR-DISEASE; SCIENTIFIC STATEMENT;
   STRESS REDUCTION; TRANSCENDENTAL-MEDITATION; METABOLIC SYNDROME;
   HEALTH-EDUCATION; CONTROLLED-TRIAL; PREVENTION; MANAGEMENT
AB Background: In the U.S., Black adults do not achieve the same life expectancy as their White counterparts, and this is attributable in large part to the development of cardiovascular disease (CVD). Mind-body therapy (MBT) interventions demonstrate improvements in cardiometabolic risk (CMR) factors that promote CVD, with increased feasibility and acceptability in the general population. Less known is the feasibility, acceptability, and evidence of reduction in CMR factors in the U.S. Black population with MBT. Purpose: This study aimed to synthesize the current state of research regarding MBT on CMR factors in middle-aged U.S. Black adults and identify gaps in the literature. Research Question 1: What types of studies have been conducted (study design, theoretical framework, and cultural relevance)? and Research Question 2: What is the feasibility and acceptability and effectiveness of MBT in Black adults for CMR reduction? Methods: Following PRISMA-ScR guidelines, a review of three databases was conducted. Our inclusion criteria were articles that (1) describe empirical research; (2) assessed a MBT intervention in middle-aged (35-64) adults with a minimum of 60% Black adult participants for CMR reduction; and (3) written in English. Independent reviewers selected articles for inclusion and data extraction, with a third reviewer providing consensus. Results: Fourteen articles met the eligibility criteria (n = 14). Characteristics included randomized controlled trials (8, 57.1%); single-arm (3, 21.0%); mixed methods (3, 21.0%); sample size (17-375); mean age range 43-64; female (6, 42.8%); theoretical framework (4, 28.6%); culturally adapted (7, 50.0%); and studies demonstrating feasibility and/or acceptability (7, 50.0%). Of the seven articles assessing CMR physiologic factors, five studies observed significant improvement. For the 11 studies assessing CMR psychological factors, 6 studies had statistically significant results and 3 studies identified trends toward positive statistical outcomes. Implication: A growing body of literature across research stages demonstrating acceptability, and feasibility, and evidence of effectiveness for selected outcomes of MBT in middle-aged Black adults with CMR factors shows promise. Future research recommendations include greater recruitment of Black men for MBT studies, larger sample sizes, and utilizing culturally adapted interventions for engaging Black adults in MBT for reduced CMR factors.
C1 [Martin, Danielle A.; Hook, Jane; Kim, Sunny Wonsun; Larkey, Linda; Lee, Rebecca E.] Arizona State Univ, Edson Coll Nursing & Hlth Innovat, Phoenix, AZ 85004 USA.
   [Kim, Sunny Wonsun; Larkey, Linda; Lee, Rebecca E.] Arizona State Univ, Ctr Hlth Promot & Dis Prevent, Phoenix, AZ USA.
C3 Arizona State University; Arizona State University-Downtown Phoenix;
   Arizona State University; Arizona State University-Downtown Phoenix
RP Martin, DA (corresponding author), Arizona State Univ, Edson Coll Nursing & Hlth Innovat, Phoenix, AZ 85004 USA.
EM Danielle.Martin@asu.edu
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NR 49
TC 0
Z9 0
U1 2
U2 2
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 2296-2565
J9 FRONT PUBLIC HEALTH
JI Front. Public Health
PD FEB 20
PY 2025
VL 13
AR 1480369
DI 10.3389/fpubh.2025.1480369
PG 20
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA Z4N5O
UT WOS:001438696100001
PM 40051519
OA gold
DA 2025-06-11
ER

PT J
AU Sawyer, C
   Carney, R
   Hassan, L
   Bucci, S
   Sainsbury, J
   Lovell, K
   Torous, J
   Firth, J
AF Sawyer, Chelsea
   Carney, Rebekah
   Hassan, Lamiece
   Bucci, Sandra
   Sainsbury, John
   Lovell, Karina
   Torous, John
   Firth, Joseph
TI Digital Lifestyle Interventions for Young People With Mental Illness: A
   Qualitative Study Among Mental Health Care Professionals
SO JMIR HUMAN FACTORS
LA English
DT Article
DE digital health; behavior change; mental health care professionals;
   physical health; lifestyle intervention; qualitative; thematic analysis;
   service optimization; mobile phone
ID CARDIOMETABOLIC RISK; PHYSICAL-ACTIVITY; DISORDERS; PSYCHOSIS; CHILDREN;
   MHEALTH
AB Background: Given the physical health disparities associated with mental illness, targeted lifestyle interventions are required to reduce the risk of cardiometabolic disease. Integrating physical health early in mental health treatment among young people is essential for preventing physical comorbidities, reducing health disparities, managing medication side effects, and improving overall health outcomes. Digital technology is increasingly used to promote fitness, lifestyle, and physical health among the general population. However, using these interventions to promote physical health within mental health care requires a nuanced understanding of the factors that affect their adoption and implementation. Objective: Using a qualitative design, we explored the attitudes of mental health care professionals (MHCPs) toward digital technologies for physical health with the goal of illuminating the opportunities, development, and implementation of the effective use of digital tools for promoting healthier lifestyles in mental health care. Methods: Semistructured interviews were conducted with MHCPs (N=13) using reflexive thematic analysis to explore their experiences and perspectives on using digital health to promote physical health in youth mental health care settings. Results: Three overarching themes from the qualitative analysis are reported: (1) motivation will affect implementation, (2) patients' readiness and capability, and (3) reallocation of staff roles and responsibilities. The subthemes within, and supporting quotes, are described. Conclusions: The use of digital means presents many opportunities for improving the provision of physical health interventions in mental health care settings. However, given the limited experience of many MHCPs with these technologies, formal training and additional support may improve the likelihood of implementation. Factors such as patient symptomatology, safety, and access to technology, as well as the readiness, acceptability, and capability of both MHCPs and patients to engage with digital tools, must also be considered. In addition, the potential benefits of data integration must be carefully weighed against the associated risks. (JMIR Hum Factors 2024;11:e53406) doi: 10.2196/53406
C1 [Sawyer, Chelsea; Hassan, Lamiece; Bucci, Sandra; Firth, Joseph] Univ Manchester, Div Psychol & Mental Hlth, 3-005 Jean Mcfarlane Bldg, Manchester M13 9PL, England.
   [Carney, Rebekah; Sainsbury, John] Greater Manchester Mental Hlth NHS Fdn Trust, Manchester, England.
   [Lovell, Karina] Univ Manchester, Div Nursing Midwifery & Social Work, Manchester, England.
   [Torous, John] Harvard Med Sch, Beth Israel Deaconness Med Ctr, Boston, MA USA.
C3 University of Manchester; University of Manchester; Harvard University;
   Harvard University Medical Affiliates; Beth Israel Deaconess Medical
   Center; Harvard Medical School
RP Firth, J (corresponding author), Univ Manchester, Div Psychol & Mental Hlth, 3-005 Jean Mcfarlane Bldg, Manchester M13 9PL, England.
EM Joseph.firth@manchester.ac.uk
RI sawyer, chelsea/IYJ-5414-2023; Firth, Joseph/JOZ-1679-2023; Carney,
   Rebekah/AAO-5205-2021; Torous, John/AFN-7229-2022; Hassan,
   Lamiece/AAJ-2718-2020; Lovell, Karina/E-6410-2012; Hassan,
   Lamiece/V-9845-2017
OI Bucci, Sandra/0000-0002-6197-5333; Torous, John/0000-0002-5362-7937;
   Carney, Rebekah/0000-0002-2859-6825; Lovell, Karina/0000-0001-8821-895X;
   Sainsbury, John/0000-0002-9386-4865; Hassan,
   Lamiece/0000-0002-5888-422X; sawyer, chelsea/0000-0003-2596-1580
FU University of Manchester Presidential Fellowship [P123958]; UK Research
   and Innovation Future Leaders Fellowship [MR/T021780/1];  [NIHR300794]
FX The authors would like to thank all the mental health care professionals
   who participated and helped recruit participants for this study. This
   study was funded by the University of Manchester Presidential Fellowship
   (P123958) and a UK Research and Innovation Future Leaders Fellowship
   (MR/T021780/1) . SB is funded by a research professorship (NIHR300794) .
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NR 42
TC 0
Z9 0
U1 1
U2 4
PU JMIR PUBLICATIONS, INC
PI TORONTO
PA 130 QUEENS QUAY East, Unit 1100, TORONTO, ON M5A 0P6, CANADA
SN 2292-9495
J9 JMIR HUM FACTORS
JI JMIR Hum. Factors
PY 2024
VL 11
AR e53406
DI 10.2196/53406
PG 14
WC Health Care Sciences & Services; Medical Informatics
WE Emerging Sources Citation Index (ESCI)
SC Health Care Sciences & Services; Medical Informatics
GA TJ8E3
UT WOS:001240979200002
PM 38837191
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Kilbourne, AM
   Lai, ZS
   Bowersox, N
   Pirraglia, P
   Bauer, MS
AF Kilbourne, Amy M.
   Lai, Zongshan
   Bowersox, Nicholas
   Pirraglia, Paul
   Bauer, Mark S.
TI Does colocated care improve access to cardiometabolic screening for
   patients with serious mental illness?
SO GENERAL HOSPITAL PSYCHIATRY
LA English
DT Article
DE Mental disorders; Quality of care; Cardiovascular disease; Integrated
   care
ID HEALTH-CARE; INDIVIDUALS; DISEASE
AB Objective: Individuals with serious mental illness (SMI; e.g., schizophrenia, bipolar disorder) experience disparities in mortality relative to the general population, mainly because of medical conditions (i.e., cardiometabolic disease). We assessed whether VA patients with SMI and receiving care from VA mental health facilities with colocated medical care were more likely to receive cardiometabolic risk assessments in accordance with clinical practice guidelines than patients from noncolocateld facilities.
   Methods: Patients with SMI identified prescribed second-generation antipsychotic medications in fiscal year (FY) 2007 receiving care from VA mental health facilities completing the VA Mental Health Program Survey were included. VA administrative data were ascertained to assess receipt of the following tests every 6 months in FY 2007: body mass index (BMI), blood pressure, lipid profile and fasting glucose.
   Results: Out of 40,600 patients with SMI prescribed second-generation antipsychotics, 29% received all cardiometabolic tests (lipid, glucose, BMI and blood pressure). While 79% and 76% received blood pressure and BMI assessments, respectively, only 37% received a lipid test. Patients from colocated sites were more likely to receive all cardiometabolic tests (odds ratio=1.26, 95% confidence interval: 1.18-1.35, P<.001).
   Conclusions: Colocated general medical providers in mental health clinics are more likely to provide cardiometabolic assessments for patients with SMI prescribed second-generation antipsychotics. Published by Elsevier Inc.
C1 [Kilbourne, Amy M.; Lai, Zongshan; Bowersox, Nicholas] VA Ann Arbor Ctr Clin Management Res, Ann Arbor, MI 48105 USA.
   [Kilbourne, Amy M.; Lai, Zongshan; Bowersox, Nicholas] Univ Michigan, Dept Psychiat, Sch Med, Ann Arbor, MI 48109 USA.
   [Pirraglia, Paul] Brown Univ, Ctr Syst Outcomes & Qual Chron Dis & Rehabil, Providence VA Med Ctr, Providence, RI 02908 USA.
   [Pirraglia, Paul] Brown Univ, Alpert Med Sch, Providence, RI 02908 USA.
   [Bauer, Mark S.] VA Boston Ctr Org, Leadership & Management Res, Boston, MA 01230 USA.
   [Bauer, Mark S.] Harvard Univ, Sch Med, Boston, MA 01230 USA.
C3 University of Michigan System; University of Michigan; US Department of
   Veterans Affairs; Veterans Health Administration (VHA); Providence VA
   Medical Center; Brown University; Brown University; Harvard University;
   Harvard Medical School
RP Kilbourne, AM (corresponding author), VA Ann Arbor Hlth Serv Res & Dev Ctr Excellence, Ann Arbor, MI 48105 USA.
EM amykilbo@umich.edu
OI Bowersox, Nicholas/0000-0001-9867-4326
FU Department of Veterans Affairs, Veterans Health Administration, Health
   Services Research and Development Service [IIR 07-115]; National
   Institute of Mental Health [MH 74509, MH 79994]
FX This work was supported by the Department of Veterans Affairs, Veterans
   Health Administration, Health Services Research and Development Service
   (IIR 07-115) and the National Institute of Mental Health (MH 74509; MH
   79994). The views expressed in this article are those of the authors and
   do not necessarily represent the views of the Department of Veterans
   Affairs. The authors report no conflicts of interest financial or
   nonfinancial in relation to this study.
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NR 16
TC 20
Z9 22
U1 0
U2 6
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0163-8343
EI 1873-7714
J9 GEN HOSP PSYCHIAT
JI Gen. Hosp. Psych.
PD NOV-DEC
PY 2011
VL 33
IS 6
BP 634
EP 636
DI 10.1016/j.genhosppsych.2011.07.003
PG 3
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 848EU
UT WOS:000297034000016
PM 21872334
OA Green Accepted, Green Submitted
DA 2025-06-11
ER

PT J
AU Rajpathak, SN
   Crandall, JP
   Wylie-Rosett, J
   Kabat, GC
   Rohan, TE
   Hu, FB
AF Rajpathak, Swapnil N.
   Crandall, Jill P.
   Wylie-Rosett, Judith
   Kabat, Geoffrey C.
   Rohan, Thomas E.
   Hu, Frank B.
TI The role of iron in type 2 diabetes in humans
SO BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
LA English
DT Review
DE Iron; Ferritin; Type 2 diabetes; Insulin resistance
ID CARDIOVASCULAR RISK-FACTORS; SOLUBLE TRANSFERRIN RECEPTOR; SERUM
   FERRITIN LEVELS; INSULIN-RESISTANCE SYNDROME; POLYCYSTIC-OVARY-SYNDROME;
   CORONARY HEART-DISEASE; HFE GENE; GLUCOSE-TOLERANCE; OXIDATIVE STRESS;
   H63D MUTATIONS
AB The role of micronutrients in the etiology of type 2 diabetes is not well established. Several lines of evidence suggest that iron play may a role in the pathogenesis of type 2 diabetes. Iron is a strong pro-oxidant and high body iron levels are associated with increased level of oxidative stress that may elevate the risk of type 2 diabetes. Several epidemiological studies have reported a positive association between high body iron stores, as measured by circulating ferritin level, and the risk of type 2 diabetes and of other insulin resistant states such as the metabolic syndrome, gestational diabetes and polycystic ovarian syndrome. In addition, increased dietary intake of iron, especially that of heme iron, is associated with risk of type 2 diabetes in apparently healthy populations. Results from studies that have evaluated the association between genetic mutations related to iron metabolism have been inconsistent. Further, several clinical trials have suggested that phlebotomy induced reduction in body iron levels may improve insulin sensitivity in humans. However, no interventional studies have yet directly evaluated the effect of reducing iron intake or body iron levels on the risk of developing type 2 diabetes. Such studies are required to prove the causal relationship between moderate iron overload and diabetes risk. (C) 2008 Elsevier B.V. All rights reserved.
C1 [Rajpathak, Swapnil N.; Wylie-Rosett, Judith; Kabat, Geoffrey C.; Rohan, Thomas E.] Albert Einstein Coll Med, Dept Epidemiol & Populat Hlth, Bronx, NY 10461 USA.
   [Crandall, Jill P.] Albert Einstein Coll Med, Dept Med, Div Endocrinol, Bronx, NY 10461 USA.
   [Hu, Frank B.] Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA.
   [Hu, Frank B.] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.
C3 Montefiore Medical Center; Albert Einstein College of Medicine; Yeshiva
   University; Yeshiva University; Montefiore Medical Center; Albert
   Einstein College of Medicine; Harvard University; Harvard T.H. Chan
   School of Public Health; Harvard University; Harvard T.H. Chan School of
   Public Health
RP Rajpathak, SN (corresponding author), Albert Einstein Coll Med, Dept Epidemiol & Populat Hlth, Bronx, NY 10461 USA.
EM srajpath@aecom.yu.edu
RI Hu, Frank/C-1919-2013
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NR 191
TC 277
Z9 298
U1 0
U2 56
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0304-4165
EI 1872-8006
J9 BBA-GEN SUBJECTS
JI Biochim. Biophys. Acta-Gen. Subj.
PD JUL
PY 2009
VL 1790
IS 7
SI SI
BP 671
EP 681
DI 10.1016/j.bbagen.2008.04.005
PG 11
WC Biochemistry & Molecular Biology; Biophysics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics
GA 463XJ
UT WOS:000267467100012
PM 18501198
DA 2025-06-11
ER

PT J
AU Radic, M
   Belancic, A
   Dogas, H
   Vuckovic, M
   Sener, YZ
   Sener, S
   Fajkic, A
   Radic, J
AF Radic, Mislav
   Belancic, Andrej
   Dogas, Hana
   Vuckovic, Marijana
   Sener, Yusuf Ziya
   Sener, Seher
   Fajkic, Almir
   Radic, Josipa
TI Cardiometabolic Risk in Psoriatic Arthritis: A Hidden Burden of
   Inflammation and Metabolic Dysregulation
SO METABOLITES
LA English
DT Review
DE psoriatic arthritis; cardiometabolic risk; adipokines; systemic
   inflammation; oxidative stress; insulin resistance; dyslipidemia
ID VASCULAR OXIDATIVE STRESS; CARDIOVASCULAR RISK; ENDOTHELIAL DYSFUNCTION;
   RHEUMATOID-ARTHRITIS; INSULIN-RESISTANCE; TNF-ALPHA; SUBCLINICAL
   ATHEROSCLEROSIS; ARTERIAL-HYPERTENSION; NITRIC-OXIDE; DISEASE
AB Psoriatic arthritis (PsA) is a chronic inflammatory disease that extends beyond musculoskeletal and dermatologic involvement to elevate cardiometabolic risk. Emerging evidence highlights the critical role of systemic inflammation in metabolic dysregulation, accelerating insulin resistance, dyslipidemia, and oxidative stress, all of which contribute to the increased burden of cardiovascular disease in PsA. This review explores the intricate interplay between inflammatory mediators-such as tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin-17 (IL-17),-adipokine imbalances, and lipid metabolism abnormalities, all of which foster endothelial dysfunction and atherosclerosis. The dysregulation of adipokines, including leptin, adiponectin, and resistin, further perpetuates inflammatory cascades, exacerbating cardiovascular risk. Additionally, the metabolic alterations seen in PsA, particularly insulin resistance and lipid dysfunction, not only contribute to cardiovascular comorbidities but also impact disease severity and therapeutic response. Understanding these mechanistic links is imperative for refining risk stratification strategies and tailoring interventions. By integrating targeted immunomodulatory therapies with metabolic and cardiovascular risk management, a more comprehensive approach to PsA treatment can be achieved. Future research must focus on elucidating shared inflammatory and metabolic pathways, enabling the development of innovative therapeutic strategies to mitigate both systemic inflammation and cardiometabolic complications in PsA.
C1 [Radic, Mislav] Univ Hosp Split, Ctr Excellence Syst Sclerosis Croatia, Dept Internal Med, Div Rheumatol Allergol & Clin Immunol, Split 21000, Croatia.
   [Radic, Mislav; Radic, Josipa] Univ Split, Sch Med, Internal Med Dept, Split 21000, Croatia.
   [Belancic, Andrej] Univ Rijeka, Fac Med, Dept Basic & Clin Pharmacol Toxicol, Brace Branchetta 20, Rijeka 51000, Croatia.
   [Dogas, Hana] Univ Hosp Split, Dept Neurol, Split 21000, Croatia.
   [Vuckovic, Marijana; Radic, Josipa] Univ Hosp Split, Dept Internal Med, Div Nephrol & Dialysis, Split 21000, Croatia.
   [Sener, Yusuf Ziya] Erasmus Univ, Sophia Childrens Hosp, Med Ctr, Dept Pediat Rheumatol, NL-3000 CB Rotterdam, Netherlands.
   [Sener, Seher] Erasmus Univ, Med Ctr, Dept Obstet & Gynecol, NL-3000 CB Rotterdam, Netherlands.
   [Fajkic, Almir] Univ Sarajevo, Fac Med, Dept Pathophysiol, Sarajevo 71000, Bosnia & Herceg.
C3 University of Split; University of Split; University of Rijeka;
   University of Split; University of Split; Erasmus University Rotterdam;
   Erasmus MC; Erasmus MC - Sophia Children's Hospital; Erasmus University
   Rotterdam; Erasmus MC; University of Sarajevo
RP Radic, J (corresponding author), Univ Split, Sch Med, Internal Med Dept, Split 21000, Croatia.; Belancic, A (corresponding author), Univ Rijeka, Fac Med, Dept Basic & Clin Pharmacol Toxicol, Brace Branchetta 20, Rijeka 51000, Croatia.; Radic, J (corresponding author), Univ Hosp Split, Dept Internal Med, Div Nephrol & Dialysis, Split 21000, Croatia.
EM mislavradic@gmail.com; andrej.belancic@uniri.hr; hana.dogas@gmail.com;
   mavuckovic@kbsplit.hr; yzsener@yahoo.com.tr; kzl_seher@hotmail.com;
   almir.fajkic@mf.unsa.ba; josiparadic1973@gmail.com
RI Şener, Yusuf Ziya/ABE-2758-2021; Radic, Josipa/H-3321-2017; Radic,
   Mislav/H-3306-2017; Dogas, Hana/HLQ-7862-2023; Belancic,
   Andrej/T-1511-2018
OI Belancic, Andrej/0000-0001-7848-6600
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NR 161
TC 0
Z9 0
U1 0
U2 0
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2218-1989
J9 METABOLITES
JI Metabolites
PD MAR 18
PY 2025
VL 15
IS 3
AR 206
DI 10.3390/metabo15030206
PG 25
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 0OV9P
UT WOS:001452489800001
PM 40137170
OA gold
DA 2025-06-11
ER

PT J
AU Lehto, SM
   Huotari, A
   Niskanen, L
   Tolmunen, T
   Koivumaa-Honkanen, H
   Honkalampi, K
   Ruotsalainen, H
   Herzig, KH
   Viinamäki, H
   Hintikka, J
AF Lehto, S. M.
   Huotari, A.
   Niskanen, L.
   Tolmunen, T.
   Koivumaa-Honkanen, H.
   Honkalampi, K.
   Ruotsalainen, H.
   Herzig, K. -H.
   Viinamaki, H.
   Hintikka, J.
TI Serum adiponectin and resistin levels in major depressive disorder
SO ACTA PSYCHIATRICA SCANDINAVICA
LA English
DT Article
DE adiponectin; coronary heart disease; major depressive disorder;
   metabolic syndrome; resistin
ID NECROSIS-FACTOR-ALPHA; METABOLIC SYNDROME; INSULIN-RESISTANCE;
   PROINFLAMMATORY MARKERS; GENE-EXPRESSION; ABSOLUTE AMOUNT;
   ADIPOSE-TISSUE; INFLAMMATION; PLASMA; CYTOKINES
AB Objective:
   To examine the role of the adipose-tissue-derived low-grade inflammation markers adiponectin and resistin in major depressive disorder (MDD) in a population-based sample.
   Method:
   Serum levels of adiponectin and resistin were measured from 70 DSM-IV MDD subjects and 70 healthy controls. Depression severity was assessed with the 29-item Hamilton Depression Rating Scale.
   Results:
   The MDD group had lowered serum adiponectin levels. Regression modelling with adjustments for age, gender, overweight, several socioeconomic and lifestyle factors, coronary heart disease and metabolic syndrome showed that each 5.0 mu g/ml decrease in serum adiponectin increased the likelihood of MDD by approximately 20% (P = 0.01). The resistin levels correlated with atypical (P = 0.02), but not with typical depressive symptoms (P = 0.12).
   Conclusion:
   Our findings suggest that the lowered adiponectin levels in MDD are depression-specific and not explained by conventional low adiponectin-related factors such as such as coronary heart disease and metabolic disorders.
C1 [Lehto, S. M.; Tolmunen, T.; Herzig, K. -H.; Viinamaki, H.; Hintikka, J.] Kuopio Univ Hosp, Dept Psychiat, SF-70210 Kuopio, Finland.
   [Lehto, S. M.; Niskanen, L.; Tolmunen, T.; Herzig, K. -H.; Viinamaki, H.; Hintikka, J.] Univ Kuopio, Kuopio 70210, Finland.
   [Lehto, S. M.; Honkalampi, K.] Kuopio Psychiat Ctr, Kuopio, Finland.
   [Huotari, A.; Ruotsalainen, H.; Herzig, K. -H.] Univ Oulu, Inst Biomed, Div Physiol, Oulu, Finland.
   [Huotari, A.; Ruotsalainen, H.; Herzig, K. -H.] Univ Oulu, Bioctr Oulu, Oulu, Finland.
   [Niskanen, L.] Kuopio Univ Hosp, Dept Med, SF-70210 Kuopio, Finland.
   [Koivumaa-Honkanen, H.] Univ Oulu, Dept Psychiat, Rovaniemi, Finland.
   [Koivumaa-Honkanen, H.] Lapland Hosp Dist, Rovaniemi, Finland.
C3 University of Eastern Finland; University of Eastern Finland Hospital;
   Kuopio University Hospital; University of Eastern Finland; University of
   Oulu; University of Oulu; University of Eastern Finland; University of
   Eastern Finland Hospital; Kuopio University Hospital; University of Oulu
RP Lehto, SM (corresponding author), Kuopio Univ Hosp, Dept Psychiat, SF-70210 Kuopio, Finland.
EM Soili.Lehto@kuh.fi
RI Koivumaa-Honkanen, Heli/L-1274-2015
OI Lehto, Soili/0000-0003-4324-6679; Ruotsalainen, Heli/0000-0003-4923-5196
FU Kuopio University; Finnish Graduate School of Psychiatry; Foundation for
   Psychiatric Research; Finnish Medical Foundation; Academy of Finland
   [116996]
FX SML was supported by Kuopio University Hospital EVO funding, the Finnish
   Graduate School of Psychiatry and research grants from the Foundation
   for Psychiatric Research and Finnish Medical Foundation. HK-H was
   supported by the Academy of Finland (grant 116996). K-HH was supported
   by a fellowship from the Academy of Finland.
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NR 52
TC 80
Z9 90
U1 0
U2 8
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0001-690X
EI 1600-0447
J9 ACTA PSYCHIAT SCAND
JI Acta Psychiatr. Scand.
PD MAR
PY 2010
VL 121
IS 3
BP 209
EP 215
DI 10.1111/j.1600-0447.2009.01463.x
PG 7
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 553SU
UT WOS:000274387900006
PM 19694629
DA 2025-06-11
ER

PT J
AU Morikawa, M
   Okamoto, N
   Kiuchi, K
   Tomioka, K
   Iwamoto, J
   Harano, A
   Saeki, K
   Fukusumi, M
   Hashimoto, K
   Amano, N
   Hazaki, K
   Yanagi, M
   Iki, M
   Yamada, F
   Kishimoto, T
   Kurumatani, N
AF Morikawa, Masayuki
   Okamoto, Nozomi
   Kiuchi, Kuniaki
   Tomioka, Kimiko
   Iwamoto, Junko
   Harano, Akihiro
   Saeki, Keigo
   Fukusumi, Masami
   Hashimoto, Kazumichi
   Amano, Nobuko
   Hazaki, Kan
   Yanagi, Motokazu
   Iki, Masayuki
   Yamada, Fumio
   Kishimoto, Toshifumi
   Kurumatani, Norio
TI Association between depressive symptoms and metabolic syndrome in
   Japanese community-dwelling older people: a cross-sectional analysis
   from the baseline results of the Fujiwara-kyo prospective cohort study
SO INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
LA English
DT Article
DE metabolic syndrome; depressive symptoms; community-dwelling older
   people; cross-sectional design; logistic regression analysis
ID SLEEP QUALITY INDEX; ELDERLY PERSONS; HEALTH; RISK; IMPAIRMENT;
   INSTRUMENT; ADULTS
AB ObjectiveMetabolic syndrome contains many risks for medical diseases such as cardiovascular disease and diabetes, which might precipitate depressive symptoms in the older people. However, the association between depressive symptoms and metabolic syndrome in Japanese community-dwelling older people is unclear. This study was performed to answer this important question.
   MethodsCross-sectional analyses were performed on 3796 community-dwelling independent older people (65years, 1911 men and 1885 women) from the 2007-2008 baseline examination of the Fujiwara-kyo study, a prospective cohort study on successful aging. Depressive symptoms were assessed using the 15-item short form of the Geriatric Depression Scale and metabolic syndrome was defined according to the 2005 International Diabetes Federation. Covariates were social supports, negative life events, health behavior, education, cognitive function, anthropometric status, and others. Multiple logistic regression analyses were performed to determine the relationships between depressive symptoms and these variables.
   ResultsThe prevalence of depressive symptoms (Geriatric Depression Scale-15 6) and metabolic syndrome were 14.8% and 16.6%, respectively. Significant protective factors against depressive symptoms were higher education, more opportunity for drinking of alcohol, better social supports, and more walking daily. Metabolic syndrome was statistically associated with depressive symptoms (adjusted odds ratio=1.32, 95% confidence interval=1.03-1.68). Other risk factors significantly associated with depressive symptoms were sleep disturbance, visual or hearing impairment, and negative life events.
   ConclusionsThe present study showed an association between metabolic syndrome and depressive symptoms in ambulatory Japanese older people, as in western countries.
C1 [Morikawa, Masayuki] Sakai City Mental Hlth Ctr, Osaka, Japan.
   [Morikawa, Masayuki; Kiuchi, Kuniaki; Fukusumi, Masami; Hashimoto, Kazumichi; Kishimoto, Toshifumi] Nara Med Univ, Dept Psychiat, Nara, Japan.
   [Okamoto, Nozomi; Tomioka, Kimiko; Saeki, Keigo; Kurumatani, Norio] Nara Med Univ, Dept Community Hlth & Epidemiol, Nara, Japan.
   [Iwamoto, Junko] Tenri Hlth Care Univ, Dept Nursing, Nara, Japan.
   [Harano, Akihiro] Hanna Cent Hosp, Dept Orthoped Surg, Nara, Japan.
   [Amano, Nobuko; Yanagi, Motokazu] Tezukayama Gakuin Univ, Dept Food & Nutr, Nara, Japan.
   [Hazaki, Kan] Osaka Electrocommun Univ, Dept Phys Therapy, Osaka, Japan.
   [Iki, Masayuki] Kinki Univ, Sch Med, Dept Publ Hlth, Osaka 589, Japan.
   [Yamada, Fumio] Osaka Univ Human Sci, Dept Hlth Psychol & Psychophysiol, Osaka, Japan.
C3 Nara Medical University; Nara Medical University; Osaka
   Electro-Communication University; Kindai University (Kinki University);
   The University of Osaka
RP Morikawa, M (corresponding author), Sakai City Mental Hlth Ctr, Osaka, Japan.
EM morikawa-ma@city.sakai.lg.jp
RI SAEKI, KEIGO/GWU-5723-2022
OI Kiuchi, Kuniaki/0000-0003-3305-5270
FU Nara Medical University, Nara, Japan [J070400032, J090400003,
   J100400001, J110400001]; KAKENHI, Tokyo, Japan [24591726]; Grants-in-Aid
   for Scientific Research [24591726, 22790566] Funding Source: KAKEN
FX This work was supported by research grants from the Nara Medical
   University (No. J070400032, J090400003, J100400001, J110400001), Nara,
   Japan and KAKENHI (grant-in-aid for scientific research C [No.
   24591726]), Tokyo, Japan.
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NR 44
TC 31
Z9 32
U1 1
U2 22
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0885-6230
EI 1099-1166
J9 INT J GERIATR PSYCH
JI Int. J. Geriatr. Psychiatr.
PD DEC
PY 2013
VL 28
IS 12
BP 1251
EP 1259
DI 10.1002/gps.3950
PG 9
WC Geriatrics & Gerontology; Gerontology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Psychiatry
GA 245MC
UT WOS:000326466800005
PM 23526542
DA 2025-06-11
ER

PT J
AU Pizent, A
   Pavlovic, M
   Jurasovic, J
   Dodig, S
   Pasalic, D
   Mujagic, R
AF Pizent, A.
   Pavlovic, M.
   Jurasovic, J.
   Dodig, S.
   Pasalic, D.
   Mujagic, R.
TI ANTIOXIDANTS, TRACE ELEMENTS AND METABOLIC SYNDROME IN ELDERLY SUBJECTS
SO JOURNAL OF NUTRITION HEALTH & AGING
LA English
DT Article
DE Trace elements; antioxidant enzymes; metabolic syndrome; obesity;
   elderly
ID OXIDATIVE STRESS; SERUM COPPER; SELENIUM LEVELS; LIPID PROFILE; ZINC;
   SUPPLEMENTATION; ASSOCIATION; EXPOSURE; DISEASE; HEALTH
AB Objective: To examine whether concentrations of several trace elements and activities of several antioxidant enzymes are modified in metabolic syndrome, and to evaluate their possible association with metabolic syndrome components. Additionally, concentration of CRP, as a marker of inflammation, was measured. Design: Cross-sectional study. Participants: The study group consisted of 100 subjects, aged 71-88 years. Measurements: Anthropometric measurements and biochemical analyses of fasting blood samples were performed by standardized methods. According to the International Diabetic Federation (IDF) criteria, metabolic syndrome was diagnosed in 64 subjects. Whole blood glutathione peroxidase (GPx), erythrocyte superoxide dismutase (SOD) and catalase (CAT), serum selenium (SSe), copper (SCu) and zinc (SZn), glucose, lipoprotein profile and C-reactive protein (CRP) were determined in all subjects. Results: No clear influence of metabolic syndrome on SSe, SZn and SCu concentration and SOD and CAT activity was found. However, significantly higher GPx was found in subjects with metabolic syndrome than in subjects without metabolic syndrome (p=0.029), as well as in subjects with hypertriglyceridemia than in control subjects (p=0.038). After adjusting for potentially confounding variables by multiple regression, significant positive relationship between SCu and CRP was found, indicating that elevated levels of Cu could have influence on inflammatory mechanisms. Conclusion: Our results suggest that GPx and CRP, as biomarkers of oxidative stress and chronic inflammation, respectively, have significant role in the pathogenesis of metabolic syndrome.
C1 [Pizent, A.; Pavlovic, M.; Jurasovic, J.] Inst Med Res & Occupat Hlth, HR-10001 Zagreb, Croatia.
   [Dodig, S.] Srebrnjak Childrens Hosp, Dept Clin Lab Diag, Zagreb, Croatia.
   [Pasalic, D.] Univ Zagreb, Sch Med, Dept Chem & Biochem, Zagreb 41001, Croatia.
   [Mujagic, R.] Univ Hosp Sister Mercy, Inst Clin Chem, Zagreb, Croatia.
C3 Institute for Medical Research & Occupational Health (IMROH); University
   of Zagreb
RP Pizent, A (corresponding author), Inst Med Res & Occupat Hlth, Ksaverska Cesta 2, HR-10001 Zagreb, Croatia.
EM apizent@imi.hr
RI Pasalic, Daria/AAC-8025-2020; Jurasovic, Jasna/ABD-9777-2020; Pizent,
   Alica/AAY-8363-2020
OI Jurasovic, Jasna/0000-0002-3183-7327; Pizent, Alica/0000-0003-0216-0166
FU Ministry of Science, Education and Sports, Republic of Croatia
   [022-0222411-2407]
FX This study was partially sponsored by the Ministry of Science, Education
   and Sports, Republic of Croatia, Grant No. 022-0222411-2407. Data were
   presented at the 3rd International Symposium Nutrition, Oxygen Biology
   and Medicine, held in Paris, April 8-10, 2009.
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NR 38
TC 36
Z9 40
U1 0
U2 18
PU SPRINGER FRANCE
PI PARIS
PA 22 RUE DE PALESTRO, PARIS, 75002, FRANCE
SN 1279-7707
EI 1760-4788
J9 J NUTR HEALTH AGING
JI J. Nutr. Health Aging
PD DEC
PY 2010
VL 14
IS 10
BP 866
EP 871
DI 10.1007/s12603-010-0139-1
PG 6
WC Geriatrics & Gerontology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology; Nutrition & Dietetics
GA 708YR
UT WOS:000286400700012
PM 21125208
OA hybrid
DA 2025-06-11
ER

PT J
AU Onyegbutulem, HC
   H-Onyegbutulem, PI
   Reimann, M
   Li, J
   Bornstein, SR
   Schwarz, PE
AF Onyegbutulem, H. C.
   H-Onyegbutulem, P. I.
   Reimann, M.
   Li, J.
   Bornstein, S. R.
   Schwarz, P. E.
TI Metabolic Syndrome in Africa: An Emerging Perspective
SO HORMONE AND METABOLIC RESEARCH
LA English
DT Review
DE HIV treatment; urbanization; metabolic risk
ID TYPE-2 DIABETES-MELLITUS; INSULIN-RESISTANCE; OBESITY; PREVENTION;
   PREVALENCE; CAMEROON; STRESS; URBAN; HYPERTENSION; ASSOCIATION
AB The high prevalence of human immunodeficiency virus infection and the emergence of HIV-related metabolic syndrome from its successful treatment in African countries are discussed. The classical factors fuelling metabolic syndrome as well as the role of urbanization are considered in this review. The future impact of ongoing conflicts and famine in large parts of Africa on the burden of metabolic syndrome in this region is given some attention. The current pattern of metabolic syndrome in Africa may be modified to an even more distinct form, far from that seen elsewhere.
C1 [Schwarz, P. E.] Tech Univ Dresden, Dept Med 3, Med Fac Carl Gustav Carus, Div Endocrinol,Clin Internal Med 3, D-01307 Dresden, Germany.
   [Onyegbutulem, H. C.; Reimann, M.; Li, J.] Asokoro Hosp Abuja, Abuja, Nigeria.
C3 Technische Universitat Dresden; Carl Gustav Carus University Hospital
RP Schwarz, PE (corresponding author), Tech Univ Dresden, Dept Med 3, Med Fac Carl Gustav Carus, Div Endocrinol,Clin Internal Med 3, D-01307 Dresden, Germany.
EM peter.schwarz@uniklinikum-dresden.de
RI Schwarz, Peter/B-5127-2013; Li, Jiang/M-4276-2014; Onyegbutulem,
   Henry/ABG-8218-2021
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NR 43
TC 8
Z9 9
U1 0
U2 3
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0018-5043
EI 1439-4286
J9 HORM METAB RES
JI Horm. Metab. Res.
PD FEB
PY 2009
VL 41
IS 2
BP 75
EP 78
DI 10.1055/s-0028-1082038
PG 4
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 417FI
UT WOS:000264061500002
PM 19085825
DA 2025-06-11
ER

PT J
AU Briet, M
   Schiffrin, EL
AF Briet, Marie
   Schiffrin, Ernesto L.
TI The Role of Aldosterone in the Metabolic Syndrome
SO CURRENT HYPERTENSION REPORTS
LA English
DT Article
DE Metabolic syndrome; Aldosterone; Obesity; Mineralocorticoid receptor;
   Insulin resistance; Salt load; Cardiovascular fibrosis;
   Glomerulosclerosis; Hypertension
ID MINERALOCORTICOID RECEPTOR; PLASMA-ALDOSTERONE; INSULIN-RESISTANCE;
   OXIDATIVE STRESS; ADIPOSE-TISSUE; HYPERTENSIVE-RATS; PROTEIN-KINASE;
   SPIRONOLACTONE; EPLERENONE; OBESITY
AB The metabolic syndrome associates metabolic abnormalities such as insulin resistance and dyslipidemia with increased waist circumference and hypertension. It is a major public health concern, as its prevalence could soon reach 30% to 50% in developed countries. Aldosterone, a mineralocorticoid hormone classically involved in sodium balance regulation, is increased in patients with metabolic syndrome. Besides its classic actions, aldosterone and mineralocorticoid receptor (MR) activation affect glucose metabolism, inducing insulin resistance through various mechanisms that involve oxidative stress, inflammation, and downregulation of proteins involved in insulin signaling pathways. Aldosterone and MR signaling exert deleterious effects on the cardiovascular system and the kidney that influence the cardiovascular risk associated with metabolic syndrome. Salt load plays a major role in cardiovascular injury induced by aldosterone and MR signaling. Large multicenter, randomized clinical trials testing the beneficial effects of MR antagonists on cardiovascular events and mortality in patients with metabolic syndrome are needed.
C1 [Briet, Marie; Schiffrin, Ernesto L.] SMBD Jewish Gen Hosp, Dept Med, Montreal, PQ H3T 1E2, Canada.
C3 Jewish General Hospital - Montreal
RP Briet, M (corresponding author), SMBD Jewish Gen Hosp, Dept Med, B-127,3755 Cote Ste Catherine Rd, Montreal, PQ H3T 1E2, Canada.
EM mariebriet1@free.fr
RI Schiffrin, Ernesto/AAB-9061-2019; Briet, Marie/K-7385-2015
OI Schiffrin, Ernesto/0000-0002-4502-2823; Briet, Marie/0000-0003-3738-5998
FU Canadian Institutes of Health Research (CIHR) [MOP37137, MOP82790,
   MOP102606]; Government of Canada; Canada Fund for Innovation; Heart and
   Stroke Foundation of Canada
FX The work of the authors was supported by Canadian Institutes of Health
   Research (CIHR) grants MOP37137, MOP82790, and MOP102606; a Canada
   Research Chair (CRC) on Hypertension and Vascular Research from the
   CIHR/CRC Program of the Government of Canada; the Canada Fund for
   Innovation (E.L.S.); and a Fellowship from the Heart and Stroke
   Foundation of Canada (M.B.).
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NR 69
TC 77
Z9 82
U1 1
U2 5
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1522-6417
EI 1534-3111
J9 CURR HYPERTENS REP
JI Curr. Hypertens. Rep.
PD APR
PY 2011
VL 13
IS 2
BP 163
EP 172
DI 10.1007/s11906-011-0182-2
PG 10
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 729CM
UT WOS:000287925700012
PM 21279740
DA 2025-06-11
ER

PT J
AU Liang, XH
   Zhang, P
   Luo, SQ
   Zhang, GF
   Tang, X
   Liu, LJ
AF Liang, Xiaohua
   Zhang, Peng
   Luo, Shunqing
   Zhang, Guifang
   Tang, Xian
   Liu, Lingjuan
TI The association of quality of life and personality characteristics with
   adolescent metabolic syndrome: a cohort study
SO HEALTH AND QUALITY OF LIFE OUTCOMES
LA English
DT Article
DE Quality of life; Personality traits; Adolescent; Metabolic syndrome;
   Cohort study
ID RISK-FACTORS; HEALTH; PREVALENCE; WEIGHT; OBESITY; STRESS; CHILDHOOD;
   CHILDREN; BIRTH
AB Background An increased prevalence of adolescent metabolic syndrome (MS) is associated with adulthood cardiovascular diseases. This study aimed to explore the potential relationship of quality of life (QoL) and personality traits with adolescent MS. Methods A total of 1961 participants from Chongqing with an average age of 11.68 years old from a cohort study established in 2014 and followed up through 2019 were included. QoL information, Eysenck's personality questionnaire and MS components were collected. Results A higher QoL domain score of physical activity ability (PAA) was a protective factor for both MS and MS score (all P < 0.01), which was mainly negatively correlated with the MS components of central obesity, diastolic blood pressure (DBP) and triglyceride levels, as well as positively correlated with high density lipoprotein cholesterol (HDL-C) level. The total QoL score was negatively correlated with triglyceride levels and positively correlated with DBP (all P < 0.01). High extraversion personality score was a protective factor against adolescent MS (P = 0.04) and MS score (P < 0.05), which were mainly negatively correlated with the MS components of waist circumference, systolic blood pressure and TGs, and positively correlated with HDL-C (all P <= 0.01). Conclusions QoL score and extraversion personality score were independent protective factors against both MS prevalence and MS score, suggesting that community intervention to improve the QoL and psychological health of children are essential.
C1 [Liang, Xiaohua; Tang, Xian; Liu, Lingjuan] Chongqing Med Univ, Clin Epidemiol & Biostat Dept,Childrens Hosp, Minist Educ,Key Lab Child Dev & Disorders,China I, Key Lab Pediat Chongqing,Natl Clin Res Ctr Child, 136 2nd St, Chongqing 400016, Peoples R China.
   [Zhang, Peng] Dis Control & Prevent Ctr Jiulongpo Dist, Chongqing, Peoples R China.
   [Luo, Shunqing] Chongqing Med Univ, Med Gen Ward Childrens Hosp, Chongqing, Peoples R China.
   [Zhang, Guifang] Chongqing Med Univ, Plast Surg Dept, Childrens Hosp, Chongqing, Peoples R China.
C3 Chongqing Medical University; Ministry of Education - China; Chongqing
   Medical University; Chongqing Medical University
RP Liang, XH (corresponding author), Chongqing Med Univ, Clin Epidemiol & Biostat Dept,Childrens Hosp, Minist Educ,Key Lab Child Dev & Disorders,China I, Key Lab Pediat Chongqing,Natl Clin Res Ctr Child, 136 2nd St, Chongqing 400016, Peoples R China.
EM xiaohualiang@hospital.cqmu.edu.cn
RI 张, 鹏/HPH-2080-2023; Liang, Xiaohua/ADJ-8830-2022; Tang, Xian/Q-1975-2016
OI liang, xiaohua/0000-0003-3867-9779
FU Joint Medical Research Project of Chongqing Municipal Health Commission
   [2020MSXM062]; Basic Research Project of Key Laboratory of Ministry of
   Education of China in 2021 [GBRP-202106]; National Key Research and
   Development Project of the Ministry of Science and Technology of the
   People's Republic of China [2017YFC0211705]; Young Scientists Fund
   Program of the National Natural Science Foundation of China [81502826];
   School Funded Project of Chongqing Medical University [CQMUNCP0204];
   Young Scientists Fund Program of the Education Commission of Chongqing
   [KJQN201900443]; General Program of the China Postdoctoral Science
   Foundation [2014M562289]; Chongqing Postdoctoral Research Funded
   Projects [Xm2014129]; Chongqing Science and Technology Bureau
   [2020MSXM062]
FX This work was supported by the Joint Medical Research Project of
   Chongqing Municipal Health Commission and Chongqing Science and
   Technology Bureau (No. 2020MSXM062), the Basic Research Project of Key
   Laboratory of Ministry of Education of China in 2021 (GBRP-202106), the
   National Key Research and Development Project of the Ministry of Science
   and Technology of the People's Republic of China (No.2017YFC0211705),
   Young Scientists Fund Program of the National Natural Science Foundation
   of China (No.81502826), School Funded Project of Chongqing Medical
   University (No.CQMUNCP0204), Young Scientists Fund Program of the
   Education Commission of Chongqing (No.KJQN201900443), General Program of
   the China Postdoctoral Science Foundation (No.2014M562289), and
   Chongqing Postdoctoral Research Funded Projects (No.Xm2014129). The
   funders had no role in the study design, the data collection and
   analysis, the decision to publish, or the preparation of the manuscript.
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NR 46
TC 17
Z9 18
U1 1
U2 8
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1477-7525
J9 HEALTH QUAL LIFE OUT
JI Health Qual. Life Outcomes
PD JUN 8
PY 2021
VL 19
IS 1
AR 160
DI 10.1186/s12955-021-01797-7
PG 13
WC Health Care Sciences & Services; Health Policy & Services
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services
GA ST8UW
UT WOS:000662714700002
PM 34103067
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Ma, LH
   Zhang, T
   Ma, HB
   Wang, H
   Jiao, CH
   Jiang, XL
AF Ma LIhua
   Zhang Tao
   Ma Hongbi
   Wang Hui
   Jiao Caihong
   Jiang Xiaolian
TI Metabolic syndrome risk in relation to posttraumatic stress disorder
   among trauma-exposed civilians in Gansu Province, China
SO MEDICINE
LA English
DT Article
DE gender; lipid; metabolic syndrome; posttraumatic stress disorder; PTSD
   checklist-civilian version (PCL-C)
ID CORONARY-HEART-DISEASE; INSULIN-RESISTANCE; SYMPTOMS; PTSD; PEOPLE;
   CHECKLIST; BEHAVIOR; OBESITY; GENDER; IMPACT
AB This study included 1456 men and 1411 women who were trauma-exposed and underwent routine health examinations in a community epidemiological investigation. The participants completed the posttraumatic stress disorder (PTSD) Check List-Civilian Version (PCL-C) for PTSD and medical examinations to detect metabolic syndrome. Adjustments for age, marriage, exercise, education, cigarette smoking, cancer, stroke, angina, and thyroid disease were performed. The relationship between PTSD and metabolic syndrome and each of its components was analyzed by multiple logistic regression. In women, PTSD was associated with metabolic syndrome (OR = 1.53, 95% CI = 1.01-1.95, P = .047) and the high-density lipoprotein cholesterol component (OR = 1.98, 95% CI = 1.04-2.12, P = .002). In men, PTSD was related to the hypertension component of metabolic syndrome (OR = 0.54, 95% CI = 0.31-0.92, P = .023). There was also a relationship between PTSD severity and metabolism (OR = 1.141, 95% CI = 1.002-1.280, P = 0.037) in women, and PTSD was inversely associated with the hypertension component (OR = 0.54, 95% CI = 0.31-0.92, P = .023) in men. PTSD was related to metabolic syndrome only in women. We plan to further research the mechanism of sex differences and dyslipidemia.
C1 [Ma LIhua; Jiang Xiaolian] Sichuan Univ, Inst Emergency Management & Reconstruct Postdisas, Chengdu, Peoples R China.
   [Zhang Tao] 940 Hosp Joint Logist Support Force Chinese Peopl, Dept Spine Surg, Lanzhou, Peoples R China.
   [Ma Hongbi] Northwest Minzu Univ, Sch Civil Engn, Lanzhou, Peoples R China.
   [Ma LIhua; Wang Hui] Lanzhou Univ, Hosp 1, Lanzhou, Peoples R China.
   [Jiao Caihong] First Hosp Long Nan City, Lanzhou, Gansu, Peoples R China.
   [Jiang Xiaolian] Sichuan Univ, West China Hosp, Nursing Dept, Chengdu 610041, Peoples R China.
C3 Sichuan University; Northwest Minzu University; Lanzhou University;
   Sichuan University
RP Jiang, XL (corresponding author), Sichuan Univ, West China Hosp, Nursing Dept, Chengdu 610041, Peoples R China.
EM jhshuoshi@163.com
FU Fundamental Research Funds for the Central University in China
   [31920150018]
FX This work was supported by grant 31920150018 from the Fundamental
   Research Funds for the Central University in China.
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NR 36
TC 9
Z9 10
U1 1
U2 9
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD JAN
PY 2020
VL 99
IS 1
AR e18614
DI 10.1097/MD.0000000000018614
PG 9
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA LD2LG
UT WOS:000525863600052
PM 31895815
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Sil, R
   Ray, D
   Chakraborti, AS
AF Sil, Rajarshi
   Ray, Doel
   Chakraborti, Abhay Sankar
TI Glycyrrhizin ameliorates metabolic syndrome-induced liver damage in
   experimental rat model
SO MOLECULAR AND CELLULAR BIOCHEMISTRY
LA English
DT Article
DE Metabolic syndrome; Glycyrrhizin; Liver damage; Oxidative stress;
   Apoptosis; Inflammation
ID PROTEIN-KINASE-C; NF-KAPPA-B; OXIDATIVE STRESS; INSULIN-RESISTANCE;
   ACID; GLUCOSE; APOPTOSIS; GLUTATHIONE; OXIDASE; CELL
AB Glycyrrhizin, a major constituent of licorice (Glycyrrhiza glabra) root, has been reported to ameliorate insulin resistance, hyperglycemia, dyslipidemia, and obesity in rats with metabolic syndrome. Liver dysfunction is associated with this syndrome. The objective of this study is to investigate the effect of glycyrrhizin treatment on metabolic syndrome-induced liver damage. After induction of metabolic syndrome in rats by high fructose (60 %) diet for 6 weeks, the rats were treated with glycyrrhizin (50 mg/kg body weight, single intra-peritoneal injection). After 2 weeks of treatment, rats were sacrificed to collect blood samples and liver tissues. Compared to normal, elevated activities of serum alanine transaminase, alkaline phosphatase and aspartate transaminase, increased levels of liver advanced glycation end products, reactive oxygen species, lipid peroxidation, protein carbonyl, protein kinase C alpha, NADPH oxidase-2, and decreased glutathione cycle components established liver damage and oxidative stress in fructose-fed rats. Activation of nuclear factor kappa B, mitogen-activated protein kinase pathways as well as signals from mitochondria were found to be involved in liver cell apoptosis. Increased levels of cyclooxygenase-2, tumor necrosis factor, and interleukin-12 proteins suggested hepatic inflammation. Metabolic syndrome caused hepatic DNA damage and poly-ADP ribose polymerase cleavage. Fluorescence-activated cell sorting using annexin V/propidium iodide staining confirmed the apoptotic hepatic cell death. Histology of liver tissue also supported the experimental findings. Treatment with glycyrrhizin reduced oxidative stress, hepatic inflammation, and apoptotic cell death in fructose-fed rats. The results suggest that glycyrrhizin possesses therapeutic potential against hepatocellular damage in metabolic syndrome.
C1 [Sil, Rajarshi; Ray, Doel; Chakraborti, Abhay Sankar] Univ Calcutta, Univ Coll Sci, Dept Biophys Mol Biol & Bioinformat, Kolkata 700009, W Bengal, India.
C3 University of Calcutta
RP Chakraborti, AS (corresponding author), Univ Calcutta, Univ Coll Sci, Dept Biophys Mol Biol & Bioinformat, 92 Acharyya Prafulla Chandra Rd, Kolkata 700009, W Bengal, India.
EM ascbmbg@caluniv.ac.in
FU University Grants Commission (UGC), India; Council of Scientific and
   Industrial Research (CSIR), India
FX R. S received research fellowship from University Grants Commission
   (UGC), India. D. R received research fellowship from Council of
   Scientific and Industrial Research (CSIR), India. Assistances from the
   Departmental Special Assistance Programme of UGC and Centre for Research
   in Nanoscience and Nanotechnology (CRNN), University of Calcutta are
   gratefully acknowledged.
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NR 77
TC 37
Z9 38
U1 2
U2 32
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0300-8177
EI 1573-4919
J9 MOL CELL BIOCHEM
JI Mol. Cell. Biochem.
PD NOV
PY 2015
VL 409
IS 1-2
BP 177
EP 189
DI 10.1007/s11010-015-2523-y
PG 13
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA CS4IX
UT WOS:000362040600018
PM 26400710
DA 2025-06-11
ER

PT J
AU Cai, DS
   Liu, TW
AF Cai, Dongsheng
   Liu, Tiewen
TI Inflammatory cause of metabolic syndrome via brain stress and NF-κB
SO AGING-US
LA English
DT Article
DE Brain; hypothalamus; stress; inflammation; NF-kappa B; metabolic
   syndrome; disease
ID ENDOPLASMIC-RETICULUM STRESS; UNFOLDED PROTEIN RESPONSE; HIGH-FAT DIET;
   CENTRAL-NERVOUS-SYSTEM; OBESITY-INDUCED INFLAMMATION; MECHANISMS LINKING
   OBESITY; HEPATIC INSULIN-RESISTANCE; REGULATING ENERGY-BALANCE; JUN
   NH2-TERMINAL KINASE; WHITE ADIPOSE-TISSUE
AB Metabolic syndrome, a network of medical disorders that greatly increase the risk for developing metabolic and cardiovascular diseases, has reached epidemic levels in many areas of today's world. Despite this alarming medicare situation, scientific understandings on the root mechanisms of metabolic syndrome are still limited, and such insufficient knowledge contributes to the relative lack of effective treatments or preventions for related diseases. Recent interdisciplinary studies from neuroendocrinology and neuroimmunology fields have revealed that overnutrition can trigger intracellular stresses to cause inflammatory changes mediated by molecules that control innate immunity. This type of nutrition-related molecular inflammation in the central nervous system, particularly in the hypothalamus, can form a common pathogenic basis for the induction of various metabolic syndrome components such as obesity, insulin resistance, and hypertension. Proinflammatory NF-kappa B pathway has been revealed as a key molecular system for pathologic induction of brain inflammation, which translates overnutrition and resulting intracellular stresses into central neuroendocrine and neural dysregulations of energy, glucose, and cardiovascular homeostasis, collectively leading to metabolic syndrome. This article reviews recent research advances in the neural mechanisms of metabolic syndrome and related diseases from the perspective of pathogenic induction by intracellular stresses and NF-kappa B pathway of the brain.
C1 [Cai, Dongsheng] Yeshiva Univ Albert Einstein Coll Med, Dept Mol Pharmacol, Bronx, NY 10461 USA.
   Yeshiva Univ Albert Einstein Coll Med, Diabet Res Ctr, Bronx, NY 10461 USA.
C3 Yeshiva University; Montefiore Medical Center; Albert Einstein College
   of Medicine; Montefiore Medical Center; Albert Einstein College of
   Medicine; Yeshiva University
RP Cai, DS (corresponding author), Yeshiva Univ Albert Einstein Coll Med, Dept Mol Pharmacol, 1300 Morris Pk Ave, Bronx, NY 10461 USA.
EM dongsheng.cai@einstein.yu.edu
RI Cai, Dongsheng/CAH-8271-2022
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NR 269
TC 147
Z9 157
U1 0
U2 14
PU IMPACT JOURNALS LLC
PI ORCHARD PARK
PA 6666 E QUAKER ST, STE 1, ORCHARD PARK, NY 14127 USA
SN 1945-4589
J9 AGING-US
JI Aging-US
PD FEB
PY 2012
VL 4
IS 2
BP 98
EP 115
DI 10.18632/aging.100431
PG 18
WC Cell Biology; Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Geriatrics & Gerontology
GA 931SS
UT WOS:000303240200005
PM 22328600
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Regina, MCD
   Tambascia, MA
AF de Oliveira Regina, Maria Cristina
   Tambascia, Marcos Antonio
TI Depression and alexithymia on weight perception in patients with
   metabolic syndrome and type 2 diabetes
SO DIABETOLOGY & METABOLIC SYNDROME
LA English
DT Article
DE Perception of weight; Actual body mass index; Reported or declared body
   mass index; Dyslipidemia; Hypertension; Type 2 diabetes mellitus;
   Alexithymia; Depression; Anxiety and psychological aspects
ID FMRI; HEALTH; STATE; RISK
AB Background: Obesity's increasing follows decreased perception of weight status in obese persons, mainly female, undergoing age-related changes.
   Objective: To study weight perception and psychological alterations associated to MS and T2DM.
   Methods: 200 patients selected from Metabolic Syndrome Outpatient Clinic of University of Campinas. Instruments: Beck Depression and Beck Anxiety Inventories', Toronto Alexithymia Scale-26s, questionnaire and data from reports. Approved by Unicamp Research Ethic Committee.
   Results: Patients aged 18-40 years perceived their weight higher than actual (A < D) (p = 0.0272), amongst untreated hypertensive (p = 0.037). = 41 years old patient's subdivided into A = D and A > D. A = D had 4.3 more chances to be alexithymic than A < D. 35% of A < D accepted their physical appearance, contrarily A = D (66%) and A > D (69%) (p = 0.0018). 50% of A < D felt offended by social aggression due to their weight; A = D (20%) and A > D (34%) (p = 0.007). 3.6 more chances of A > D than A < D using anti-hypertensive drugs (p = 0.021) (>= 41 years old) and 3.5 more chances to perceive A = D (41-60 years old) (p = 0.023). A = D presented 3.8 more chances of depression than A < D and 4.3 more chances of alexithymia than A < D (62% of 41-60 year-old patients with higher cholesterol, mainly LDL and hyper-triglycerides). A = D with alexithymia, partially linked with higher cholesterol, suggests neuroinflammation due to hypertriglycerides. Females, who declared had been anteriorly made diet as treatment to lose weight were exactly those who perceived their weight A > D (45%, p = 0.0091).
   Conclusions: Age as a period of development, in which cultural influences occurs, was a factor in weight misperception. A < D and A > D were distinct in age, history of obesity and BMI.
C1 [de Oliveira Regina, Maria Cristina] Univ Estadual Campinas, Dept Human Being Dev & Rehabil, Fac Med, Campinas, SP, Brazil.
   [Tambascia, Marcos Antonio] Univ Estadual Campinas, Dept Internal Med Endocrinol Metab Syndrome & Dia, Fac Med, Campinas, SP, Brazil.
C3 Universidade Estadual de Campinas; Universidade Estadual de Campinas
RP Regina, MCD (corresponding author), Univ Estadual Campinas, Dept Human Being Dev & Rehabil, Fac Med, Campinas, SP, Brazil.
EM cdregina@mpc.com.br
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NR 39
TC 3
Z9 3
U1 0
U2 6
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1758-5996
J9 DIABETOL METAB SYNDR
JI Diabetol. Metab. Syndr.
PD MAY 12
PY 2017
VL 9
AR 34
DI 10.1186/s13098-017-0222-4
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA EU6VW
UT WOS:000401174800003
PM 28507609
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Evans, EW
   Jelalian, E
   Dunsiger, S
   Villalta, D
   Tyrka, A
AF Evans, E. Whitney
   Jelalian, Elissa
   Dunsiger, Shira
   Villalta, Douglas
   Tyrka, Audrey
TI Design of a clinical trial to isolate the experience of food insecurity
   and elucidate the biological mechanisms of risk for childhood health
   outcomes
SO CONTEMPORARY CLINICAL TRIALS
LA English
DT Article
DE Food insecurity; Childhood obesity; Adverse childhood experiences
ID BODY-MASS INDEX; CHILDREN; ADULTS; INFLAMMATION; ASSOCIATION;
   DEPRESSION; POVERTY; OBESITY; WEIGHT; GROWTH
AB Background: Food insecurity affects one in seven households with children in the United States, disproportionately impacts households headed by women and minorities, and is associated with childhood comorbidities, including obesity. While food insecurity likely contributes to poor health through its effect on diet, such a simplistic understanding likely obscures the effects of poverty-related stress and other Adverse Childhood Experiences, on metabolic health.
   Methods: Over two summers, 100 children, ages 8-12 years, will be recruited from low-income households in an urban, Rhode Island community, to participate in an 8-week trial designed to isolate the experience of food insecurity. Summer represents a natural risk period of food insecurity in children, such that children will be randomized to receive weekly shipments of five breakfast and lunch meals that mimic school meals or to experience the likely onset of summertime food insecurity and receive a weekly newsletter on community resources that is not expected to affect food insecurity. Through assessment visits at baseline, mid-summer and end of summer, we will examine group differences in change in diet quality, biomarkers of Metabolic Syndrome, inflammation, and stress, BMI z-scores, and child measures of behavior and anxiety and depression symptoms. We will also explore the impact of caregiver mood and stress on the health effects of food insecurity.
   Conclusions: Findings stand to clarify the mechanisms by which food insecurity affects child health outcomes and to inform how to best address food insecurity in the context of poverty-related stress.
C1 [Evans, E. Whitney; Jelalian, Elissa; Villalta, Douglas] Miriam Hosp, Weight Control & Diabet Res Ctr, 196 Richmond St, Providence, RI 02903 USA.
   [Evans, E. Whitney; Jelalian, Elissa; Tyrka, Audrey] Brown Univ, Warren Alpert Sch Med, Dept Psychiat & Human Behav, Providence, RI 02903 USA.
   [Dunsiger, Shira] Brown Univ, Ctr Hlth Promot & Hlth Equ, Sch Publ Hlth, Box G-121-8, Providence, RI 02912 USA.
   [Tyrka, Audrey] Butler Hosp, Lab Clin & Translat Neurosci, 345 Blackstone Blvd, Providence, RI 02906 USA.
C3 Lifespan Health Rhode Island; Miriam Hospital; Brown University; Brown
   University; Butler Hospital Rhode Island
RP Evans, EW (corresponding author), Miriam Hosp, Weight Control & Diabet Res Ctr, 196 Richmond St, Providence, RI 02903 USA.
EM whitney_evans@brown.edu
RI Tyrka, Audrey/L-2504-2014; Evans, Emrys/M-9140-2016
OI Tyrka, Audrey/0000-0003-4653-1651
FU Centers of Biomedical Research Excellence (COBRE) on Stress Resilience
   and Trauma at The Miriam Hospital [P20GM139767]
FX This work was supported by a Centers of Biomedical Research Excellence
   (COBRE) on Stress Resilience and Trauma at The Miriam Hospital
   (P20GM139767). Declaration of Competing Interest
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NR 54
TC 0
Z9 0
U1 2
U2 6
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1551-7144
EI 1559-2030
J9 CONTEMP CLIN TRIALS
JI Contemp. Clin. Trials
PD JUN
PY 2022
VL 117
AR 106751
DI 10.1016/j.cct.2022.106751
EA APR 2022
PG 6
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA 3I8AH
UT WOS:000832931800001
PM 35381377
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Paineiras-Domingos, LL
   Sá-Caputo, DC
   Francisca-Santos, A
   Reis-Silva, A
   Carvalho-Lima, RP
   Neves, MFT
   Xavier, VL
   Quinart, H
   Boyer, FC
   Sartorio, A
   Taiar, R
   Bernardo, M
AF Paineiras-Domingos, Laisa Liane
   Sa-Caputo, Danubia Cunha
   Francisca-Santos, Arlete
   Reis-Silva, Aline
   Carvalho-Lima, Rafaelle Pacheco
   Neves, Mario Fritsch T.
   Xavier, Vinicius Layter
   Quinart, Herve
   Boyer, Francois Constant
   Sartorio, Alessandro
   Taiar, Redha
   Bernardo-Filho, Mario
TI Can whole body vibration exercises promote improvement on quality of
   life and on chronic pain level of metabolic syndrome patients? A
   pseudorandomized crossover study
SO JOURNAL OF APPLIED PHYSIOLOGY
LA English
DT Article
DE chronic pain; exercise; metabolic syndrome; quality of life; vibration
ID WORLD-HEALTH-ORGANIZATION; ENDOTHELIAL DYSFUNCTION; STYLE INTERVENTION;
   PORTUGUESE VERSION; IMPACT; WOMEN; WEIGHT; WHOQOL; RISK; MEN
AB Quality of life (QoL) is one of the most important health outcome concepts expressed subjectively. Chronic pain (CP) is an unpleasant sensory and emotional experience associated with actual or potential tissue damage. Taking into account the poor QoL and the CP already described in metabolic syndrome (MSy) individuals, this study aimed to evaluate the effects of whole body vibration exercises (WBVE) on these parameters in this population. Thirty-three MSy patients were divided in subgroups A [whole body vibration exercise group (WBVeG), n = 17, 15 females/2 males, 61.1 +/- 8.4 yr] and B (control group, n = 16, 14 females/2 males, 58.2 +/- 9.1 yr). Subgroup A performed 10 sessions (2 times/wk) of WBVE (18 min/session, with a frequency from 5 up to 14 Hz and a peak-to-peak displacement of 25, 5.0. and 7.5 mm) on a side-alternating vibrating platform (VP). Subgroup B did the same protocol, but the VP was turned off. The individuals answered the World Health Organization Quality of Life bref (WHOQoL-bref) questionnaire before the first and after the 10th session. The chronic pain level (CPL) was measured by a numeric rating scale (0-10) before and at the end of each session. Significant improvements were found in physical health (P = 0.05) and psychological health (P = 0.04) domains of WHOQoL-bref in WBVeG. A significant acute reduction of the CPL was found in the WBVeG after the protocol, considering the first session and at the last session. WBVE marginally improved physical health and psychological health and decrease the CPL in acute interventions.
   NEW & NOTEWORTHY Metabolic syndrome patients experience poor quality of life, frequently associated with lack of exercise and bad dietary habits. Additionally, factors such as obesity. neummus-culoskeletal impairment. and peripheral endothelial dysfunction result in a chronic pain level. Whole body vibration exercise might represent a suitable physical therapy, since it is easy to perform, low cost, safe, and capable of promoting an improvement of quality of life and reducing chronic pain level during acute interventions in metabolic syndrome individuals.
C1 [Paineiras-Domingos, Laisa Liane; Sa-Caputo, Danubia Cunha] Univ Estado Rio de Janeiro, Programa Posgrad Ciencias Med, Rio De Janeiro, Brazil.
   [Paineiras-Domingos, Laisa Liane; Sa-Caputo, Danubia Cunha; Francisca-Santos, Arlete; Reis-Silva, Aline; Carvalho-Lima, Rafaelle Pacheco; Bernardo-Filho, Mario] Univ Estado Rio de Janeiro, Policlin Piquet Carneiro, Dept Biofis & Biometria, Lab Vibracoes Mecan & Prat Integrat, Rio De Janeiro, Brazil.
   [Paineiras-Domingos, Laisa Liane; Sa-Caputo, Danubia Cunha; Francisca-Santos, Arlete; Reis-Silva, Aline; Carvalho-Lima, Rafaelle Pacheco; Bernardo-Filho, Mario] Univ Estado Rio de Janeiro, Inst Biol Roberto Alcantara Gomes, Dept Biofis & Biometria, Lab Vibracoes Mecan & Prat Integrat, Rio De Janeiro, Brazil.
   [Paineiras-Domingos, Laisa Liane; Sa-Caputo, Danubia Cunha; Francisca-Santos, Arlete] Fac Bezerra Araujo, Rio De Janeiro, Brazil.
   [Reis-Silva, Aline] Univ Estado Rio de Janeiro, Mestrado Profiss Saude Med Lab & Tecnol Forense, Rio De Janeiro, Brazil.
   [Neves, Mario Fritsch T.] Univ Estado Rio de Janeiro, Dept Clin Med HUPE, Rio De Janeiro, Brazil.
   [Xavier, Vinicius Layter] Univ Estado Rio de Janeiro, Inst Matemat & Estat, Dept Estat, Rio De Janeiro, Brazil.
   [Quinart, Herve] Inst Format Masso Kinesitherapie, Reims, France.
   [Boyer, Francois Constant] Univ Reims, Sebastopol Hosp, Phys & Rehabil Med Dept, Reims, France.
   [Sartorio, Alessandro] IRCCS, Ist Auxol Italian, Expt Lab Auxoendocrinol Res, Milan, Italy.
   [Sartorio, Alessandro] IRCCS, Ist Auxol Italian, Expt Lab Auxoendocrinol Res, Verbania, Italy.
   [Taiar, Redha] Univ Reims, Reims, France.
C3 Universidade do Estado do Rio de Janeiro; Universidade do Estado do Rio
   de Janeiro; Universidade do Estado do Rio de Janeiro; Universidade do
   Estado do Rio de Janeiro; Universidade do Estado do Rio de Janeiro;
   Universidade do Estado do Rio de Janeiro; CHU de Reims; Universite de
   Reims Champagne-Ardenne; IRCCS Istituto Auxologico Italiano; IRCCS
   Istituto Auxologico Italiano; Universite de Reims Champagne-Ardenne
RP Paineiras-Domingos, LL (corresponding author), Univ Estado Rio de Janeiro, Inst Biol Roberto Alcantara Gomes, Dept Biofis & Biometria, Av Marechal Rondon 381, BR-20950003 Rio De Janeiro, RJ, Brazil.; Paineiras-Domingos, LL (corresponding author), Univ Estado Rio de Janeiro, Policlin Piquet Carneiro, Av Marechal Rondon 381, BR-20950003 Rio De Janeiro, RJ, Brazil.
EM laisanit@gmail.com
RI Silva, Aline/GXG-1946-2022; Sá-Caputo, Danúbia/ABH-4584-2020; Layter
   Xavier, Vinicius/HNI-9676-2023; Paineiras-Domingos, Laisa
   Liane/J-1696-2019; redha, taiar/Q-6769-2016; Sa-Caputo,
   Danubia/C-1230-2016; Sartorio, Alessandro/AAA-3581-2020; Boyer, Francois
   Constant/P-4544-2016
OI Paineiras-Domingos, Laisa Liane/0000-0003-3451-5056; Xavier, Vinicius
   Layter/0000-0002-7290-0652; redha, taiar/0000-0002-0227-3884; Sa-Caputo,
   Danubia/0000-0002-9263-1576; Sartorio, Alessandro/0000-0002-9620-4133;
   Boyer, Francois Constant/0000-0003-1035-9108
FU Coordenacao de Aperfeicoamento de Pessoal de Ensino Superior, Brazil
   [001]; Conselho Nacional de Desenvolvimento Cientifico e Tecnologico;
   Fundacao de Amparo a` Pesquisa do Estado do Rio de Janeiro
FX This study was financed in part by the Coordenacao de Aperfeicoamento de
   Pessoal de Ensino Superior, Brazil, Finance Code 001; the Conselho
   Nacional de Desenvolvimento Cientifico e Tecnologico; and the Fundacao
   de Amparo a` Pesquisa do Estado do Rio de Janeiro.
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NR 61
TC 7
Z9 7
U1 0
U2 0
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 8750-7587
EI 1522-1601
J9 J APPL PHYSIOL
JI J. Appl. Physiol.
PD APR
PY 2020
VL 128
IS 4
BP 934
EP 940
DI 10.1152/japplphysiol.00068.2019
PG 7
WC Physiology; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Physiology; Sport Sciences
GA LG8CP
UT WOS:000528322200023
PM 32078471
OA Bronze
DA 2025-06-11
ER

PT J
AU Gelaye, B
   Foster, S
   Bhasin, M
   Tawakol, A
   Fricchione, G
AF Gelaye, Bizu
   Foster, Simmie
   Bhasin, Manoj
   Tawakol, Ahmed
   Fricchione, Gregory
TI SARS-CoV-2 morbidity and mortality in racial/ethnic minority
   populations: A window into the stress related inflammatory basis of
   health disparities?
SO BRAIN BEHAVIOR & IMMUNITY-HEALTH
LA English
DT Review
ID NF-KAPPA-B; PSYCHOLOGICAL STRESS; METABOLIC-SYNDROME; EARLY-LIFE;
   INTERFERON INDUCTION; SOCIOECONOMIC-STATUS; COVID-19; PATHOPHYSIOLOGY;
   INHIBITION; EXPRESSION
AB Health disparity related to race/ethnicity has been cited as "the most serious and shameful health care issue of our time"(Peterson et al., 2018). A portion of the now recognized disproportionate impact of the COVID-19 pandemic among Black, Indigenous and People of Color (BIPOC) communities is attributable to social determinants such as socioeconomic status (SES), physical living situation, health care access, and the psychosocial factors associated with socioenvironmental circumstances such as bias, victimization, trauma and toxic stress as well as structural factors that reduce the capacity to practice physical distancing (Agurs-Collins et al., 2019). In this paper, we hypothesize that, prior to the COVID-19 pandemic, disproportionate socio-economic and environmental stressors in the BIPOC population promoted heightened stress-associated neurobiological activity (Stress-NbA). This chronic elevation in Stress-NbA results in down-stream complications of chronic stress including underactivation of anti-viral type I IFN pathway genes. This results in an increase in susceptibility to viral diseases, including coronavirus illnesses. Additionally, Stress-NbA chronically potentiates systemic inflammation (from hematopoietic system activation with myelopoiesis) increasing the prevalence of metabolic syndrome (MetS) and setting the stage for stress-related chronic non-communicable diseases (NCDs). This process was propelled by overactivation of immune cell gene expression in the nuclear factor & kappa;-light-chain-enhancer of activated B cells (NF-kB) activation pathway and underactivation of gene expression in the anti-viral type I interferon (IFN) pathway. The higher prevalence of MetS and NCDs in minority populations turned out to be predictive of the elevated risk they would face in the presence of a highly contagious viral pandemic. The stress-related generation of a chronic non pathogen associated molecular pattern (non-PAMP) immunoactivation state led to decreased viral immune defense and increased susceptibility to SARS-CoV-2 infection with increased risk of severe illness induced by cytokine storm syndrome (CSS).
C1 [Gelaye, Bizu; Foster, Simmie; Fricchione, Gregory] Harvard Med Sch, Massachusetts Gen Hosp, Dept Psychiat, Boston, MA 02115 USA.
   [Gelaye, Bizu] Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA.
   [Bhasin, Manoj] Emory Univ, Dept Pediat, Sch Med, Atlanta, GA USA.
   [Bhasin, Manoj] Emory Univ, Sch Med, Dept Biomed Bioinformat, Atlanta, GA USA.
   [Tawakol, Ahmed] Harvard Med Sch, Massachusetts Gen Hosp, Dept Med, Div Cardiol, Boston, MA USA.
   [Fricchione, Gregory] Harvard Med Sch, Massachusetts Gen Hosp, Benson Henry Inst Mind Body Med, Boston, MA USA.
C3 Harvard University; Harvard University Medical Affiliates; Massachusetts
   General Hospital; Harvard Medical School; Harvard University; Harvard
   T.H. Chan School of Public Health; Emory University; Emory University;
   Harvard University; Harvard Medical School; Harvard University Medical
   Affiliates; Massachusetts General Hospital; Harvard University; Harvard
   University Medical Affiliates; Massachusetts General Hospital; Harvard
   Medical School
RP Gelaye, B (corresponding author), Harvard Med Sch, Massachusetts Gen Hosp, Dept Psychiat, Boston, MA 02115 USA.
EM bgelaye@mgh.harvard.edu
RI Bhasin, Manoj/B-3018-2009; Gelaye, Bizu/GSI-6520-2022
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NR 99
TC 18
Z9 18
U1 0
U2 2
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2666-3546
J9 BRAIN BEHAV IMMUN-HL
JI Brain Behav. Immun.-Health
PD DEC
PY 2020
VL 9
AR 100158
DI 10.1016/j.bbih.2020.100158
PG 9
WC Immunology; Neurosciences; Psychiatry
WE Emerging Sources Citation Index (ESCI)
SC Immunology; Neurosciences & Neurology; Psychiatry
GA Q7SS2
UT WOS:001059491000003
PM 33052326
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Kusaka, H
   Koibuchi, N
   Hasegawa, Y
   Ogawa, H
   Kim-Mitsuyama, S
AF Kusaka, Hiroaki
   Koibuchi, Nobutaka
   Hasegawa, Yu
   Ogawa, Hisao
   Kim-Mitsuyama, Shokei
TI Empagliflozin lessened cardiac injury and reduced visceral adipocyte
   hypertrophy in prediabetic rats with metabolic syndrome
SO CARDIOVASCULAR DIABETOLOGY
LA English
DT Article
DE Cardiac protection; Oxidative stress; Inflammation; Metabolic syndrome;
   Prediabetes; Natriuresis; Adipose tissue
ID BARORECEPTOR REFLEX SENSITIVITY; COTRANSPORTER 2 INHIBITORS;
   DIABETES-MELLITUS; CARDIOVASCULAR OUTCOMES; OXIDATIVE STRESS; SGLT2
   INHIBITION; BLOOD-PRESSURE; DOUBLE-BLIND; TYPE-2; GLUCOSE
AB Background: The potential benefit of SGLT2 inhibitors in metabolic syndrome is with prediabetic stage unclear. This work was undertaken to investigate the non-glycemic effect of empagliflozin on metabolic syndrome rats with prediabetes.
   Methods: SHR/NDmcr-cp(+/+) rats (SHRcp), a model of metabolic syndrome with prediabetes, were given empagliflozin for 10 weeks to examine the effects on urinary sodium and water balance, visceral and subcutaneous adipocyte, and cardiac injury. Further, the effect of empagliflozin on blood pressure and autonomic nervous system was continuously investigated by using radiotelemetry system.
   Results: Empagliflozin significantly reduced urinary sodium and water balance of SHRcp only within 1 week of the treatment, but later than 1 week did not alter them throughout the treatment. Empagliflozin significantly reduced body weight of SHRcp, which was mainly attributed to the significant reduction of subcutaneous fat mass. Empagliflozin significantly reduced the size of visceral adipocytes and increased the number of smaller size of adipocytes, which was associated with the attenuation of oxidative stress. Empagliflozin ameliorated cardiac hypertrophy and fibrosis of SHRcp, in association with the attenuation of cardiac oxidative stress and inflammation. However, empagliflozin did not significantly change blood pressure, heart rate, sympathetic activity, or baroreceptor function, as evidenced by radiotelemetry analysis.
   Conclusions: Our present work provided the evidence that SGLT2 inhibition reduced visceral adipocytes hypertrophy and ameliorated cardiac injury in prediabetic metabolic syndrome rat, independently of diuretic effect or blood pressure lowering effect. Thus, SGLT2 inhibition seems to be a promising therapeutic strategy for prediabetic metabolic syndrome.
C1 [Kusaka, Hiroaki; Koibuchi, Nobutaka; Hasegawa, Yu; Kim-Mitsuyama, Shokei] Kumamoto Univ, Grad Sch Med Sci, Dept Pharmacol & Mol Therapeut, 1-1-1 Honjo, Kumamoto 8608556, Japan.
   [Ogawa, Hisao] Kumamoto Univ, Grad Sch Med Sci, Dept Cardiovasc Med, Kumamoto, Japan.
C3 Kumamoto University; Kumamoto University
RP Kim-Mitsuyama, S (corresponding author), Kumamoto Univ, Grad Sch Med Sci, Dept Pharmacol & Mol Therapeut, 1-1-1 Honjo, Kumamoto 8608556, Japan.
EM mitsuyam@gpo.kumamoto-u.ac.jp
FU Boehringer Ingelheim
FX This work was partially supported by research grants from Boehringer
   Ingelheim.
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NR 45
TC 123
Z9 133
U1 0
U2 8
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1475-2840
J9 CARDIOVASC DIABETOL
JI Cardiovasc. Diabetol.
PD NOV 11
PY 2016
VL 15
AR 157
DI 10.1186/s12933-016-0473-7
PG 14
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism
GA EH6NJ
UT WOS:000391889500001
PM 27835975
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Cappelen, H
   Ivarsson, A
   Jormfeldt, H
AF Cappelen, H.
   Ivarsson, A.
   Jormfeldt, H.
TI The Effects of an Equine-Assisted Therapeutic Intervention on Well-Being
   in Persons Diagnosed with Schizophrenia. A Pilot Study
SO ISSUES IN MENTAL HEALTH NURSING
LA English
DT Article
ID METABOLIC SYNDROME; PHYSICAL-ACTIVITY; PSYCHOTHERAPY; RECOVERY; PEOPLE;
   CHILDREN; REHABILITATION; INDIVIDUALS; ADOLESCENTS; DISORDERS
AB The process of personal recovery among persons diagnosed with schizophrenia may be facilitated through innovative health promotion interventions targeting multidimensional aspects of subjective well-being. The current pilot study aims to test the use of self-rated questionnaires as a means of evaluation of the effects of an equine-assisted intervention for persons diagnosed with schizophrenia. Twenty adults diagnosed with schizophrenia were offered a 12-week EAT intervention performed six times once every 14 days by a licensed mental health nurse. Two validated self-rated questionnaires, HSCL-25 and SHIS were used as outcome measurements at baseline and at post-treatment, additionally the self-rated questionnaire PANAS was completed twice a week starting 1 week before the 12 week-EAT intervention. Only six of the 20 participants managed to complete the validated questionnaires. Despite the low response rate of approximately 30%, a significant difference was found between pre and post scores for positive affect and well-being. Effect sizes, ranging from small to large for pre-to-post treatment scores indicated less depression and anxiety, more positive affect, less negative affect, and reinforced well-being. Results suggest that EAT interventions may have beneficial effects among persons diagnosed with schizophrenia and that a varied range of research methods are needed to create a solid evidence base for EAT interventions intended for the target group.
C1 [Cappelen, H.] Leiden Univ, Inst Psychol, Leiden, Netherlands.
   [Ivarsson, A.; Jormfeldt, H.] Halmstad Univ, Sch Hlth & Welf, Halmstad, Sweden.
   [Jormfeldt, H.] Halmstad Univ, Sch Hlth & Welf, SE-30118 Halmstad, Sweden.
C3 Leiden University; Leiden University - Excl LUMC; Halmstad University;
   Halmstad University
RP Jormfeldt, H (corresponding author), Halmstad Univ, Sch Hlth & Welf, SE-30118 Halmstad, Sweden.
EM henrika.jormfeldt@hh.se
RI Ivarsson, Andreas/ABE-5414-2020
OI Ivarsson, Andreas/0000-0002-8987-5975
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NR 63
TC 1
Z9 1
U1 0
U2 1
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 0161-2840
EI 1096-4673
J9 ISSUES MENT HEALTH N
JI Issues Ment. Health Nurs.
PD FEB 1
PY 2023
VL 44
IS 2
BP 104
EP 111
DI 10.1080/01612840.2022.2158408
EA DEC 2022
PG 8
WC Nursing; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Psychiatry
GA 9E6LH
UT WOS:000920133900001
PM 36649626
OA hybrid
DA 2025-06-11
ER

PT J
AU Kamel, FO
   Mahjoub, SK
   Ahmad, MAAS
   Jamal, MH
   Bakhshwin, DM
   Burzangi, AS
   Shaker, S
   Magadmi, R
AF Kamel, Fatemah O.
   Mahjoub, S. K.
   Ahmad, M. A. A. Sattar
   Jamal, Maha H.
   Bakhshwin, Duaa M.
   Burzangi, Abdulhadi S.
   Shaker, Soad
   Magadmi, Rania
TI Major risk factors underlying the development of metabolic syndrome in
   vitamin D-deficient rats
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Article
DE cardiovascular complications; metabolic syndrome; oxidative stress;
   vascular function; vitamin D deficiency
ID CARDIOVASCULAR-DISEASE; HEART-FAILURE; PATHOGENESIS; MANAGEMENT; INSULIN
AB Background: Vitamin D is essential for calcium-phosphorus homeostasis, skeletal mineralization, and cardiovascular health. Its deficiency is associated with increased risk of metabolic syndrome and cardiovascular diseases. In this study, we aimed to investigate the relationship between vitamin D deficiency and cardiovascular metabolic syndrome while identifying underlying mechanisms. Methodology: Forty-eight Wistar albino rats were divided into four groups: control, vitamin D deficient (VD-), metabolic syndrome (MetS), and combined vitamin D deficient with metabolic syndrome (VD- + MetS). VD- and VD- + MetS rats were fed a vitamin D-deficient diet with increased calcium and phosphate to prevent secondary hyperparathyroidism and to determine the direct effects of vitamin D. Metabolic syndrome was induced via 10% fructose in drinking water for 8 weeks. Evaluations included metabolic syndrome markers (hypertension, diabetes, dyslipidemia, and obesity), myocardial injury indicators (lactate dehydrogenase [LDH] and creatine kinase-MB [CK-MB]), and oxidative stress/inflammation markers (malondialdehyde [MDA] and nitric oxide [NO]). Vascular reactivity in thoracic aorta tissues, heart weight, and histopathological changes were also assessed. Result: The results revealed that vitamin D deficiency was strongly related to each component of metabolic syndrome. Combined vitamin D deficiency and metabolic syndrome induced a highly significant increase in CK-MB, LDH, NO, and MDA levels (p < 0.05). However, there was no significant difference in CK-MB and NO levels for the (VD-) group compared to the control (p > 0.05). Heart weight was significantly increased, and a histological examination of the heart showed increased left ventricular and aortic wall thickness in the combined group (p < 0.05). Vascular response to phenylephrine was significantly increased, whereas the vascular response to acetylcholine was significantly decreased in all experimental groups (VD-, MetS, and VD- + MetS) compared to control (p < 0.05). Conclusion: The present study demonstrates that vitamin D deficiency is considered one of the major risky and predisposing factors for cardiovascular metabolic syndrome, which could affect the outcome of the disease, partly by affecting endothelial function, vascular oxidative stress, and inflammation.
C1 [Kamel, Fatemah O.; Mahjoub, S. K.; Ahmad, M. A. A. Sattar; Jamal, Maha H.; Bakhshwin, Duaa M.; Burzangi, Abdulhadi S.; Magadmi, Rania] King Abdulaziz Univ, Fac Med, Dept Clin Pharmacol, Jeddah, Saudi Arabia.
   [Shaker, Soad] King Abdulaziz Univ, Fac Med, Anat Dept, Jeddah, Saudi Arabia.
C3 King Abdulaziz University; King Abdulaziz University
RP Magadmi, R (corresponding author), King Abdulaziz Univ, Fac Med, Dept Clin Pharmacol, Jeddah, Saudi Arabia.
EM rmagadmi@kau.edu.sa
RI Bakhshwin, Duaa/GQI-4715-2022; Burzangi, Abdulhadi/AAY-2379-2020; Kamel,
   Fatemah/HLH-3014-2023; Magadmi, Rania/KWU-5686-2024
FU Deanship of Scientific Research (DSR) at King Abdulaziz University,
   Jeddah; GPIP [361-140-2024]
FX The authors acknowledge the Deanship of Scientific Research at King
   Abdulaziz University, Jeddah, Saudi Arabia, for technical and financial
   support.
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NR 37
TC 0
Z9 0
U1 1
U2 1
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD APR 28
PY 2025
VL 16
AR 1573332
DI 10.3389/fphar.2025.1573332
PG 13
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 2KU8O
UT WOS:001485028700001
PM 40356969
DA 2025-06-11
ER

PT J
AU Khan, BV
   Sola, S
   Lauten, WB
   Natarajan, R
   Hooper, WC
   Menon, RG
   Lerakis, S
   Helmy, T
AF Khan, BV
   Sola, S
   Lauten, WB
   Natarajan, R
   Hooper, WC
   Menon, RG
   Lerakis, S
   Helmy, T
TI Quinapril, an ACE inhibitor, reduces markers of oxidative stress in the
   metabolic syndrome
SO DIABETES CARE
LA English
DT Article
ID CONVERTING ENZYME-INHIBITION; LOW-DENSITY-LIPOPROTEIN; ATHEROSCLEROSIS;
   INFLAMMATION; IRBESARTAN; DISEASE; RISK
AB OBJECTIVE - Patients with the metabolic syndrome often have abnormal levels of proinflammatory and pro-oxidative mechanisms within their vasculature. We sought to determine whether the ACE inhibitor quinapril regulates markers of oxidative stress in the metabolic syndrome.
   RESEARCH DESIGN AND METHODS - Forty patients with the metabolic syndrome were randomized in a double-blind manner to either the ACE inhibitor quinapril (20 mg/day) or matching placebo for 4 weeks. Serum markets of vascular oxidative stress were measured.
   RESULTS - After 4 weeks of therapy, serum 8-isoprostane was reduced by 12% in the quinapril group when compared with placebo (quinapril, 46.7 +/- 1.0; placebo, 52.7 +/- 0.9 pg/ml P = 0.001). Erythrocyte superoxide dismutase activity increased 35% in the quinapril group when compared with placebo (quinapril, 826.3 +/- 17.1; placebo, 612.3 +/- 6.9 units/g Hb, P < 0.001). In addition, lag time to oxidation of LDL, a marker of oxidative Stress, was increased by 48% in the quinapril group when compared with placebo (quinapril 89.2 +/- 9.2 vs. placebo 60.1 +/- 12.3 min; P < 0.001). Therapy with quinapril was well tolerated.
   CONCLUSIONS - The addition of the ACE inhibitor quinapril reduces markers of vascular oxidative stress and may attenuate the progression of the pathophysiology seen in the metabolic syndrome.
C1 Emory Univ, Sch Med, Div Cardiol, Dept Med, Atlanta, GA 30303 USA.
   City Hope Natl Med Ctr, Div Diabet & Endocrinol, Duarte, CA 91010 USA.
   Ctr Dis Control & Prevent, Atlanta, GA USA.
C3 Emory University; City of Hope; Centers for Disease Control & Prevention
   - USA
RP Emory Univ, Sch Med, Div Cardiol, Dept Med, 69 Jesse Hill Dr SE,C247, Atlanta, GA 30303 USA.
EM bkhan@emory.edu
RI Lerakis, Stamatios/AAR-7597-2021
OI Sola, Srikanth/0000-0003-1451-665X
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NR 23
TC 42
Z9 49
U1 0
U2 0
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0149-5992
EI 1935-5548
J9 DIABETES CARE
JI Diabetes Care
PD JUL
PY 2004
VL 27
IS 7
BP 1712
EP 1715
DI 10.2337/diacare.27.7.1712
PG 4
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 834FN
UT WOS:000222397100029
PM 15220251
OA Bronze
DA 2025-06-11
ER

PT J
AU Francoeur, RB
AF Francoeur, Richard B.
TI Symptom profiles of subsyndromal depression in disease clusters of
   diabetes, excess weight, and progressive cerebrovascular conditions: a
   promising new type of finding from a reliable innovation to estimate
   exhaustively specified multiple indicators-multiple causes (MIMIC)
   models
SO DIABETES METABOLIC SYNDROME AND OBESITY-TARGET & THERAPY
LA English
DT Article
DE depression; diabetes; overweight; cerebrovascular disease; hypertension;
   metabolic syndrome; stroke; vascular cognitive impairment
ID ADVERSE HEALTH OUTCOMES; METABOLIC SYNDROME; SUBTHRESHOLD DEPRESSION;
   FUNCTIONAL OUTCOMES; MAJOR DEPRESSION; GLYCEMIC CONTROL;
   ELDERLY-PATIENTS; SELF-CARE; ALEXITHYMIA; RISK
AB Addressing subsyndromal depression in cerebrovascular conditions, diabetes, and obesity reduces morbidity and risk of major depression. However, depression may be masked because self-reported symptoms may not reveal dysphoric (sad) mood. In this study, the first wave (2,812 elders) from the New Haven Epidemiological Study of the Elderly (EPESE) was used. These population-weighted data combined a stratified, systematic, clustered random sample from independent residences and a census of senior housing. Physical conditions included progressive cerebrovascular disease (CVD; hypertension, silent CVD, stroke, and vascular cognitive impairment [VCI]) and co-occurring excess weight and/or diabetes. These conditions and interactions (clusters) simultaneously predicted 20 depression items and a latent trait of depression in participants with subsyndromal (including subthreshold) depression (11 <= Center for Epidemiologic Studies Depression Scale [CES-D] score <= 27). The option for maximum likelihood estimation with standard errors that are robust to non-normality and non-independence in complex random samples (MLR) in Mplus and an innovation created by the author were used for estimating unbiased effects from latent trait models with exhaustive specification. Symptom profiles reveal masked depression in 1) older males, related to the metabolic syndrome (hypertension-overweight-diabetes; silent CVD-overweight; and silent CVD-diabetes) and 2) older females or the full sample, related to several diabetes and/or overweight clusters that involve stroke or VCI. Several other disease clusters are equivocal regarding masked depression; a couple do emphasize dysphoric mood. Replicating findings could identify subgroups for cost-effective screening of subsyndromal depression.
C1 [Francoeur, Richard B.] Adelphi Univ, Sch Social Work, Social Work Bldg,1 South Ave, Garden City, NY 11530 USA.
C3 Adelphi University
RP Francoeur, RB (corresponding author), Adelphi Univ, Sch Social Work, Social Work Bldg,1 South Ave, Garden City, NY 11530 USA.
EM francoeur@adelphi.edu
FU Hartford Geriatric Social Work Faculty Scholar Initiative; National
   Institute of Mental Health [1R03MH064627-01, 5R03MH064627-02]
FX The author received funding as the principal investigator from the
   Hartford Geriatric Social Work Faculty Scholar Initiative (no grant
   number) and the National Institute of Mental Health (grants
   1R03MH064627-01 and 5R03MH064627-02). The author wishes to thank Drs
   Susan Hughes, Jeanne Teresi, and Karolynn Siegel for their consultation
   during grantsmanship and the early phase of this project. Randy Dexter
   assisted with table formatting.
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NR 88
TC 8
Z9 10
U1 0
U2 7
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-7007
J9 DIABET METAB SYND OB
JI Diabetes Metab. Syndr. Obes.
PY 2016
VL 9
BP 391
EP 416
DI 10.2147/DMSO.S118432
PG 26
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA EE8SB
UT WOS:000389894900001
PM 28003768
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Mattoo, SK
   Chakraborty, K
   Basu, D
   Ghosh, A
   Kumar, KGV
   Kulhara, P
AF Mattoo, Surendra K.
   Chakraborty, Kaustav
   Basu, Debasish
   Ghosh, Abhishek
   Kumar, Vijaya K. G.
   Kulhara, Parmanand
TI Prevalence & correlates of metabolic syndrome in alcohol & opioid
   dependent inpatients
SO INDIAN JOURNAL OF MEDICAL RESEARCH
LA English
DT Article
DE Metabolic syndrome; prevalence; substance dependence
ID 3RD NATIONAL-HEALTH; PHYSICAL-ACTIVITY; INSULIN-RESISTANCE;
   PSYCHIATRIC-INPATIENTS; CONSUMPTION; ADULTS; MEN; ADOLESCENTS; BEVERAGE;
   SMOKING
AB Background & objectives: The research on the association of metabolic syndrome (MS) and substance abuse is scanty. The present research aimed to study the prevalence and correlates of MS among the inpatients at a Drug De-addiction Centre in north India.
   Methods: Consecutive male subjects (N=110) admitted to a drug de-addiction centre during July to December 2009 with a primary diagnosis of alcohol or opioid dependence were evaluated for the presence of MS as per the International Diabetes Federation (IDF) criteria.
   Results: The prevalence of MS was 24.6 and 29.3 per cent in alcohol and opioid dependent groups, respectively. MS showed a significant association with the age and body mass index (BMI) in the opioid dependent group. Co-morbid tobacco use was not associated with MS in either group.
   Interpretation & conclusions: The prevalence of MS in our sample of alcohol and opioid dependent male inpatients was greater than the prevalence of MS in general population, however it was comparable to that reported in physical and other psychiatric disorder populations. Even though the absence of any comparative study limits the generalizability of our findings, results indicate towards a need for screening of the patients with substance dependence especially for those aged above 30 years and/or having a high BMI for MS.
C1 [Mattoo, Surendra K.; Chakraborty, Kaustav; Basu, Debasish; Ghosh, Abhishek; Kumar, Vijaya K. G.; Kulhara, Parmanand] Postgrad Inst Med Educ & Res, Dept Psychiat, Chandigarh 160012, India.
C3 Post Graduate Institute of Medical Education & Research (PGIMER),
   Chandigarh
RP Mattoo, SK (corresponding author), Postgrad Inst Med Educ & Res, Dept Psychiat, Chandigarh 160012, India.
EM skm_ddtc@glide.net.in
RI GHOSH, ABHISHEK/AAD-9630-2019
OI Ghosh, Abhishek/0000-0002-0988-7694
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NR 36
TC 19
Z9 22
U1 0
U2 2
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, 400059, INDIA
SN 0971-5916
J9 INDIAN J MED RES
JI Indian J. Med. Res.
PD SEP
PY 2011
VL 134
IS 3
BP 341
EP 348
PG 8
WC Immunology; Medicine, General & Internal; Medicine, Research &
   Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; General & Internal Medicine; Research & Experimental
   Medicine
GA 847FD
UT WOS:000296956400014
PM 21985817
DA 2025-06-11
ER

PT J
AU Gyawali, P
   Richards, RS
   Nwose, EU
   Bwititi, PT
AF Gyawali, Prajwal
   Richards, Ross S.
   Nwose, Ezekiel Uba
   Bwititi, Phillip T.
TI Whole-blood viscosity and metabolic syndrome
SO CLINICAL LIPIDOLOGY
LA English
DT Review
DE diabetes mellitus; hypertension; metabolic syndrome; obesity whole-blood
   viscosity
ID HIGH-DENSITY-LIPOPROTEIN; FREE FATTY-ACIDS; NITRIC-OXIDE; OXIDATIVE
   STRESS; ENDOTHELIAL DYSFUNCTION; RHEOLOGICAL PROPERTIES; RISK-FACTORS;
   LIPID-PEROXIDATION; INSULIN-RESISTANCE; HEMORHEOLOGICAL PARAMETERS
AB Whole-blood viscosity (WBV) depends on vascular geometry and blood physiological constituents. Diabetes mellitus, hypertension, dyslipidemia and obesity - the major components of metabolic syndrome (MetS) can independently affect blood vessels and microcirculation. MetS is the state of oxidative stress and systemic inflammation. Pro-oxidant and inflammatory cytokines induce endothelial dysfunction. Morphological alterations of erythrocytes could be a consequence of decreased erythrocytes deformability, oxidative stress and systemic inflammation. These events altogether lead to increased WBV. In this review, the effect of WBV in different components of the MetS and WBV with regard to oxidative stress and inflammation common states in chronic disease - are discussed.
C1 [Gyawali, Prajwal; Richards, Ross S.] Charles Sturt Univ, Sch Community Hlth, Albury, NSW 2640, Australia.
   [Nwose, Ezekiel Uba] Charles Darwin Univ, Darwin, NT 0909, Australia.
   [Bwititi, Phillip T.] Charles Sturt Univ, Sch Biomed Sci, Albury, NSW 2640, Australia.
C3 Charles Sturt University; Charles Darwin University; Charles Sturt
   University
RP Gyawali, P (corresponding author), Charles Sturt Univ, Sch Community Hlth, POB 789, Albury, NSW 2640, Australia.
EM clbioprajwal@gmail.com
RI Nwose, Ezekiel 'Uba'/I-1333-2018
OI Nwose, Ezekiel 'Uba'/0000-0003-1318-9853; Gyawali,
   Prajwal/0000-0003-0975-5576; Bwititi, Phillip/0000-0002-6265-5913
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NR 118
TC 24
Z9 25
U1 0
U2 30
PU FUTURE MEDICINE LTD
PI LONDON
PA UNITEC HOUSE, 3RD FLOOR, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON, N3
   1QB, ENGLAND
SN 1758-4299
EI 1758-4302
J9 CLIN LIPIDOL
JI Clin. Lipidol.
PD DEC
PY 2012
VL 7
IS 6
BP 709
EP 719
DI 10.2217/CLP.12.65
PG 11
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 052YT
UT WOS:000312237300016
DA 2025-06-11
ER

PT J
AU Ülgen, F
   Scherbaum, WA
   Partke, HJ
   Bornstein, SR
   Schinner, S
AF Uelgen, F.
   Scherbaum, W. A.
   Partke, H. -J.
   Bornstein, S. R.
   Schinner, S.
TI Intrapancreatic adipocyte deposition in a mouse model of the metabolic
   syndrome
SO HORMONE AND METABOLIC RESEARCH
LA English
DT Article
ID STRESS
C1 [Uelgen, F.; Scherbaum, W. A.; Schinner, S.] Univ Hosp, Dept Endocrinol Diabet & Rheumatol, D-40225 Dusseldorf, Germany.
   [Partke, H. -J.] German Diabet Res Inst, German Diabet Ctr, Dusseldorf, Germany.
   [Bornstein, S. R.] Carl Gustav Carus Univ Dresden, Dept Med, Dresden, Germany.
C3 Leibniz Association; Deutsches Diabetes-Zentrum (DDZ); Technische
   Universitat Dresden; Carl Gustav Carus University Hospital
RP Schinner, S (corresponding author), Univ Hosp, Dept Endocrinol Diabet & Rheumatol, Moorenstr 5, D-40225 Dusseldorf, Germany.
EM sven.schinner@uni-duesseldorf.de
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NR 10
TC 3
Z9 3
U1 0
U2 0
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0018-5043
J9 HORM METAB RES
JI Horm. Metab. Res.
PD JUL
PY 2008
VL 40
IS 7
BP 507
EP 509
DI 10.1055/s-2008-1062722
PG 3
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 330NZ
UT WOS:000257951400014
PM 18415891
DA 2025-06-11
ER

PT J
AU Vitaliano, PP
   Murphy, M
   Young, HM
   Echeverria, D
   Borson, S
AF Vitaliano, Peter P.
   Murphy, Michael
   Young, Heather M.
   Echeverria, Diana
   Borson, Soo
TI Does Caring for a Spouse with Dementia Promote Cognitive Decline? A
   Hypothesis and Proposed Mechanisms
SO JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
LA English
DT Article
DE cognitive decline; dementia; caregiving; physiology; depression
ID VASCULAR RISK-FACTORS; ALZHEIMERS-DISEASE; CHRONIC STRESS; METABOLIC
   SYNDROME; INSULIN-RESISTANCE; PHYSICAL-ACTIVITY; PSYCHOLOGICAL DISTRESS;
   DEPRESSIVE SYMPTOMS; FAMILY CAREGIVERS; INCIDENT DEMENTIA
AB OBJECTIVE: To discuss why spouse caregivers (CGs) of people with dementia may be at higher risk for cognitive problems and decline than demographically similar people not caring for a spouse with dementia (noncaregivers; NCGs).
   DESIGN: Literature review.
   SETTING: Community.
   PARTICIPANTS: Older adults caring for a family member (primarily spouses) with dementia.
   MEASUREMENTS: Cognitive, psychosocial, physiological, and behavioral.
   RESULTS: This article reports a review of the literature examining relationships between CG status and cognitive problems in the context of a theoretical model of chronic stress. The model suggests that spouse CGs may be at higher risk of cognitive impairment or dementia than NCG spouses in response to several mediators, including psychosocial (e. g., depression, loneliness, social isolation, sleep problems), behavioral (e. g., exercise, diet), and physiological (e. g., metabolic syndrome and inflammation) variables.
   CONCLUSION: This research has important implications because it considers modifiable risk factors for dementia that, if unchecked, may compromise the lives of CGs and their ability to function. It is hoped that an understanding of such stress-mediator-cognitive processes will help clinicians, researchers, policy-makers, and stakeholders mitigate what may be characterized as an "ironic tragedy''-dementia in both members of the caregiving dyad-if left unchecked. J Am Geriatr Soc 59:900-908, 2011.
C1 [Vitaliano, Peter P.; Murphy, Michael] Univ Washington, Dept Environm Hlth, Seattle, WA 98195 USA.
   [Murphy, Michael] Univ British Columbia, Dept Psychol, Vancouver, BC, Canada.
   [Young, Heather M.] Univ Calif Davis, Davis, CA 95616 USA.
C3 University of Washington; University of Washington Seattle; University
   of British Columbia; University of California System; University of
   California Davis
RP Vitaliano, PP (corresponding author), Univ Washington, Dept Environm Hlth, 1959 NE Pacific St,Box 356560, Seattle, WA 98195 USA.
EM pvital@uw.edu
RI Young, Heather/JBS-7552-2023; Vitaliano, Peter/K-2014-2019
OI Vitaliano, peter P./0000-0003-1598-0868
FU National Institutes of Health [5R01MH057663-05, 5R01MH043267-05]
FX This work was supported by National Institutes of Health Grants
   5R01MH057663-05 and 5R01MH043267-05.
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NR 110
TC 101
Z9 123
U1 2
U2 64
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0002-8614
EI 1532-5415
J9 J AM GERIATR SOC
JI J. Am. Geriatr. Soc.
PD MAY
PY 2011
VL 59
IS 5
BP 900
EP 908
DI 10.1111/j.1532-5415.2011.03368.x
PG 9
WC Geriatrics & Gerontology; Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA 763RZ
UT WOS:000290578700018
PM 21568959
DA 2025-06-11
ER

PT J
AU Wang, LX
   Filipp, SL
   Urbina, EM
   Gurka, MJ
   DeBoer, MD
AF Wang, Linda X.
   Filipp, Stephanie L.
   Urbina, Elaine M.
   Gurka, Matthew J.
   DeBoer, Mark D.
TI Longitudinal Associations of Metabolic Syndrome Severity Between
   Childhood and Young Adulthood: The Bogalusa Heart Study
SO METABOLIC SYNDROME AND RELATED DISORDERS
LA English
DT Article
DE metabolic syndrome; cardiovascular disease; type 2 diabetes; insulin
   resistance; oxidative stress; risk
ID CONFIRMATORY FACTOR-ANALYSIS; CARDIOVASCULAR-DISEASE; URIC-ACID;
   DIABETES-MELLITUS; NATIONAL-HEALTH; RISK-FACTORS; SYNDROME-X;
   ADOLESCENTS; CHILDREN; INSULIN
AB Background: Childhood metabolic syndrome (MetS) is associated with insulin resistance and increased risk for later development of type 2 diabetes (T2DM) and cardiovascular disease (CVD). In using MetS severity z-scores, our objective was to assess longitudinal associations in MetS severity, fasting insulin levels as a sign of insulin resistance and risk for T2DM, and uric acid levels as a biomarker of oxidative stress leading to CVD. Methods: We used linear regression to analyze longitudinal data from 285 white and black participants from the Bogalusa Heart Study evaluated at baseline at ages 5-19 and as young adults after a mean of 12.0 years follow-up. We assessed correlations between childhood MetS severity and young-adult MetS severity, fasting insulin, and uric acid levels, both overall and by sex- and racial subgroups. Results: Overall, childhood MetS z-scores were positively associated with young-adult MetS z-scores (r=0.52), insulin (r=0.34), and uric acid (r=0.28) (all P<0.001). These associations were consistent across all sex- and racial subgroups, except for young adult uric acid in white males in which childhood MetS-z was not associated (r=0.15, P=0.243). There was a strong cross-sectional association of young-adult MetS z-scores with insulin (r=0.70) and uric acid (r=0.57) (both P<0.001), which was consistent for all sex- and racial subgroups. Conclusions: These positive longitudinal correlations between childhood MetS z-scores and markers of later insulin resistance and oxidative stress suggest long-term durability of risk for CVD and T2DM. This suggests potential for MetS severity to serve as an indicator to monitor for future risk of T2DM and CVD.
C1 [Wang, Linda X.; DeBoer, Mark D.] Univ Virginia, Dept Pediat, Charlottesville, VA 22908 USA.
   [Filipp, Stephanie L.; Gurka, Matthew J.] Univ Florida, Coll Med, Dept Hlth Outcomes & Policy, Gainesville, FL USA.
   [Urbina, Elaine M.] Cincinnati Childrens Hosp, Dept Cardiol, Cincinnati, OH USA.
C3 University of Virginia; State University System of Florida; University
   of Florida; Cincinnati Children's Hospital Medical Center
RP DeBoer, MD (corresponding author), Univ Virginia, Dept Pediat, Charlottesville, VA 22908 USA.
EM deboer@virginia.edu
FU National Institutes of Health [1R01HL120960]
FX This work was supported by National Institutes of Health grant
   1R01HL120960 (MJG and MDD).
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NR 34
TC 18
Z9 20
U1 0
U2 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-4196
EI 1557-8518
J9 METAB SYNDR RELAT D
JI Metab. Syndr. Relat. Disord.
PD JUN
PY 2018
VL 16
IS 5
BP 208
EP 214
DI 10.1089/met.2017.0160
EA MAR 2018
PG 7
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA GH7DD
UT WOS:000428568500001
PM 29584578
OA Green Published
DA 2025-06-11
ER

PT J
AU Duck, AA
   Karimi, M
   Watkins, LL
   Tacy, JW
   Savell, CL
   Hall, KC
AF Duck, Angela A.
   Karimi, Masoumeh
   Watkins, LaDaryl L.
   Tacy, Joseph W.
   Savell, Christy L.
   Hall, Katherine C.
TI Metabolic syndrome risk among adolescents in the Deep South and the
   relationships with behavioral health, food insecurity, and physical
   activity
SO JOURNAL FOR SPECIALISTS IN PEDIATRIC NURSING
LA English
DT Article
DE adolescent; behavioral health; food insecurity; metabolic syndrome;
   methodology; physical activity; psychosocial health
ID ADVERSE CHILDHOOD EXPERIENCES; GENERALIZED ANXIETY DISORDER; 3RD
   NATIONAL-HEALTH; SYNDROME PHENOTYPE; SEX-DIFFERENCES; PREVALENCE;
   VALIDATION; SEVERITY; QUESTIONNAIRE; CHILDREN
AB PurposeA combination of physical and psychosocial risk factors put adolescents at risk for poor cardiometabolic health and chronic disease burden, often recognized as metabolic syndrome. The purposes of this study were to (1) identify the prevalence of metabolic syndrome risk among adolescents, utilizing the metabolic syndrome severity index, and (2) determine the relationship between metabolic syndrome risk and behavioral health, food insecurity, and physical inactivity among adolescents.Methods and DesignA cross-sectional, descriptive, correlational design was deployed in an inner-city high school in the Deep South. An 8-month recruitment and enrollment period yielded a sample of 55 adolescents. A battery of measures included assessment of demographic data, anthropometric, cardiovascular, and psychosocial data. Utilizing these data elements, a progressive methodological approach was used to identify metabolic severity risk as a continuous variable for use in the adolescent population.ResultsAll participants identified as African American/Black. Among them, 71% (N = 39) were female and an average age of 16 (SD = 1.3) years old, with 67.3% (N = 37) of the sample at risk for metabolic syndrome. There was not a statistically significant relationship between metabolic syndrome severity score and behavioral health risk, food insecurity, and physical inactivity in this sample.Practice ImplicationsFuture use of the continuous metabolic syndrome severity score may guide practice by utilizing longitudinal data to assess the trends of metabolic syndrome severity scores in relation to disease outcomes in adolescents. This may promote the identification of psychosocial and physical interrelationships with metabolic syndrome, thus improving overall health through the development of age-appropriate interventions.
C1 [Duck, Angela A.; Karimi, Masoumeh; Watkins, LaDaryl L.; Tacy, Joseph W.; Savell, Christy L.; Hall, Katherine C.] Univ Mississippi, Med Ctr, Sch Nursing, Jackson, MS USA.
   [Duck, Angela A.] Univ Mississippi, Med Ctr, Sch Nursing, 2500 N State St, Jackson, MS 39216 USA.
C3 University of Mississippi Medical Center; University of Mississippi;
   University of Mississippi; University of Mississippi Medical Center
RP Duck, AA (corresponding author), Univ Mississippi, Med Ctr, Sch Nursing, 2500 N State St, Jackson, MS 39216 USA.
EM aduck@umc.edu
RI Hall, Katherine/LZG-8241-2025
OI Tacy, Joseph/0000-0003-4295-6572; Duck, Angela/0000-0002-5967-7505
FU University of Mississippi Medical Center School of Nursing Seed Grant
   [1P50MD017338-01]; National Institutes of Health [U01HL146192]; National
   Heart, Lung, & Blood Institute [UG3MD018298-01]; National Institutes of
   Health, National Institute of Minority Health and Health Disparities;
   University of Mississippi Medical Center School of Nursing Office of
   Research and Scholarship Seed Grant
FX Angela A. Duck and Katherine C. Hall are partially supported by the
   National Institutes of Health under Award Number 1P50MD017338-01.
   Katherine C. Hall is partially supported by the National Heart, Lung, &
   Blood Institute under Award Number U01HL146192. Masoumeh Karimi is
   partially supported by the National Institutes of Health, National
   Institute of Minority Health and Health Disparities under Award Number
   UG3MD018298-01. This project was funded by a University of Mississippi
   Medical Center School of Nursing Office of Research and Scholarship Seed
   Grant. The content is solely the responsibility of the authors and does
   not necessarily represent the official views of the National Institutes
   of Health.
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NR 40
TC 0
Z9 0
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1539-0136
EI 1744-6155
J9 J SPEC PEDIATR NURS
JI J. Spec. Pediatr. Nurs.
PD JAN
PY 2024
VL 29
IS 1
DI 10.1111/jspn.12420
EA DEC 2023
PG 9
WC Nursing; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Pediatrics
GA JZ7W8
UT WOS:001126899500001
PM 38095121
DA 2025-06-11
ER

PT S
AU Hainer, V
   Kabrnova, K
   Aldhoon, B
   Kunesova, M
   Wagenknecht, M
AF Hainer, Vojtech
   Kabrnova, Karolina
   Aldhoon, Bashar
   Kunesova, Marie
   Wagenknecht, Martin
BE Chrousos, GP
   Tsigos, C
TI Serotonin and norepinephrine reuptake inhibition and eating behavior
SO STRESS, OBESITY, AND METABOLIC SYNDROME
SE Annals of the New York Academy of Sciences
LA English
DT Article; Proceedings Paper
CT Bjorntorp Symposium on Stress, Obesity, and Metabolic Syndrome
CY APR 09-10, 2005
CL Athens, GREECE
SP Roche Hellas, Abbott Hellas, Pfizer Hellas, Sanofi Aventis Hellas, GlaxoSmithKline Hellas
DE serotonin; norepinephrine; eating behavior; dietary disinhibition;
   sibutramine; abdominal obesity; metabolic syndrome
ID CORONARY-HEART-DISEASE; PITUITARY-ADRENAL AXIS; BODY-FAT DISTRIBUTION;
   TERM WEIGHT-LOSS; BULIMIA-NERVOSA; CORTISOL SECRETION; CANDIDATE GENE;
   BLOOD-PRESSURE; OBESE WOMEN; SIBUTRAMINE
AB Brain neurotransmitters, serotonin and norepinephrine, play an important role in the central nervous control of energy balance and are involved in symptomatology related to both obesity and depression. Therefore both serotonin and norepinephrine neural pathways have been paid a special attention as targets for the antiobesity drugs, antidepressants, and drugs used in the treatment of eating disorders. Selective serotonin reuptake inhibitors (SSRI) have been used in the treatment of depression and eating disorders but have failed to achieve sustained weight loss in the treatment of obesity. Sibutramine, a serotonin and norepinephrine reuptake inhibitor, which induces satiety and prevents decline in metabolic rate associated with a hypocaloric diet, is currently the sole centrally acting drug indicated for the long-term treatment of obesity. Depression, dietary disinhibition (evaluated by the Eating Inventory [EI]), and stress are associated with the accumulation of abdominal fat and the development of metabolic syndrome and related diseases. Subjects with abdominal obesity demonstrate neuroendocrine abnormalities which result in disturbances in hypothalamo-pituitary-adrenal (HPA) function. Treatment with SSRI might interrupt the vicious circle which leads to endocrine abnormalities and the accumulation of abdominal fat. Obesity treatment with sibutramine results, not only in significant weight loss, but also in reduction of abdominal fat and in the improvement of health risks associated with metabolic syndrome (lipid profile, blood glucose, insulin, HbA1c, and uric acid), as well as in the decline in disinhibition score of the EI. In a 1-year sibutramine trial, only a decrease in the disinhibition score remained a significant correlate of weight loss among the psychobehavioral and nutritional factors which were taken into account.
C1 Inst Endocrinol, Obes Management Ctr, Prague 11694 1, Czech Republic.
C3 Institute of Endocrinology - Prague
RP Hainer, V (corresponding author), Inst Endocrinol, Obes Management Ctr, Narodni 8, Prague 11694 1, Czech Republic.
EM vhainer@endo.cz
OI Aldhoon, Bashar/0000-0002-1845-847X
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NR 76
TC 73
Z9 79
U1 0
U2 15
PU BLACKWELL SCIENCE PUBL
PI OXFORD
PA OSNEY MEAD, OXFORD OX2 0EL, ENGLAND
SN 0077-8923
BN 978-1-57331-625-5
J9 ANN NY ACAD SCI
JI Ann.NY Acad.Sci.
PY 2006
VL 1083
BP 252
EP 269
DI 10.1196/annals.1367.017
PG 18
WC Endocrinology & Metabolism; Multidisciplinary Sciences
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Science & Technology - Other Topics
GA BFR90
UT WOS:000244102900017
PM 17148744
DA 2025-06-11
ER

PT J
AU Gallagher, P
   Boland, C
   McClenaghan, A
   Fanning, F
   Lawlor, E
   Clarke, M
AF Gallagher, Peter
   Boland, Cailin
   McClenaghan, Aisling
   Fanning, Felicity
   Lawlor, Elizabeth
   Clarke, Mary
TI Improved self-esteem and activity levels following a 12-week community
   activity and healthy lifestyle programme in those with serious mental
   illness: A feasibility study
SO EARLY INTERVENTION IN PSYCHIATRY
LA English
DT Article
DE community; low cost; physical activity; premature mortality; serious
   mental illness
ID SOCIAL-PARTICIPATION INTERVENTIONS; CARDIOVASCULAR RISK-FACTORS; MAJOR
   DEPRESSIVE DISORDER; PHYSICAL-ACTIVITY; BIPOLAR DISORDER; SEDENTARY
   TIME; WEIGHT-LOSS; SCHIZOPHRENIA; PEOPLE; ADULTS
AB Background Those with serious mental illness (SMI) including both psychotic and affective disorders are recognized to have a premature mortality compared to the general population, at least in part due to elevated cardiovascular risk profile.
   Aim To examine the effect of a 12-week, pragmatic, sustainable, low-cost intervention involving community activity, nutritional advice and exercise that could be accessible to patients attending a community clinic.
   Methods Participants (N = 35) with SMI attending a community mental health service who were considered at risk of metabolic syndrome were referred by their clinical teams to a specialized healthy activity and nutritional programme. The intervention involved participation in exercise, dietary education and targeted lifestyle advice focused on community activities. Data on physical health and clinical parameters were collected pre- and post-intervention.
   Results Physical activity increased following the intervention along with a statistically significant increase in self-esteem scores. There was no significant reduction in body mass index or lowering of anxiety and depression scores.
   Conclusions It is feasible to develop a relatively low-cost, community-based physical activity programme, integrating both nutritional advice and healthy activities. This may lead to improved outcomes in cardiovascular risk profile and improved life expectancy.
C1 [Gallagher, Peter; Boland, Cailin; McClenaghan, Aisling; Fanning, Felicity; Lawlor, Elizabeth; Clarke, Mary] Detect Early Intervent Psychosis Serv, Dublin, Ireland.
   [Gallagher, Peter; McClenaghan, Aisling; Fanning, Felicity; Lawlor, Elizabeth; Clarke, Mary] St John God Community Serv CLG, Dublin, Ireland.
   [Boland, Cailin; Clarke, Mary] Univ Coll Dublin, Sch Med & Med Sci, Dublin, Ireland.
C3 University College Dublin
RP Gallagher, P (corresponding author), Detect Early Intervent Psychosis Serv, Dublin, Ireland.
EM peter.gallagherdetect@sjog.ie
RI Boland, Cailin/AAZ-1513-2020
OI Clarke, Mary/0000-0002-1491-9355
CR [Anonymous], 2013, WORLD PSYCHIAT
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NR 40
TC 6
Z9 6
U1 0
U2 18
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1751-7885
EI 1751-7893
J9 EARLY INTERV PSYCHIA
JI Early Interv. Psychiatry
PD APR
PY 2021
VL 15
IS 2
BP 367
EP 373
DI 10.1111/eip.12965
EA APR 2020
PG 7
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA QP0JZ
UT WOS:000528592400001
PM 32337860
DA 2025-06-11
ER

PT J
AU Fan, HH
   Ren, QL
   Sheng, ZJ
   Deng, GX
   Li, LM
AF Fan, Huanhuan
   Ren, Qingling
   Sheng, Zhejin
   Deng, Ganxiu
   Li, Limei
TI The role of the thyroid in polycystic ovary syndrome
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Review
DE pcos; thyroid; metabolic abnormalities; reproductive disorders;
   potential mechanism
ID BODY-MASS INDEX; STIMULATING-HORMONE; INSULIN-RESISTANCE; SUBCLINICAL
   HYPOTHYROIDISM; METABOLIC SYNDROME; HIGH PREVALENCE;
   DIAGNOSTIC-CRITERIA; NODULAR GOITER; WOMEN; ASSOCIATION
AB Polycystic ovary syndrome (PCOS) is the most common endocrine and metabolic disease in women of childbearing age and can cause metabolic disorder, infertility, and increased anxiety and depression; as a result, it can seriously affect the physical and mental health of fertile women. PCOS is a highly clinically heterogeneous disease with unclear etiology and pathogenesis, which increases the difficulty of treatment. The thyroid gland has complex regulatory effects on metabolism, reproduction, and emotion, and produces hormones that act on almost all cells of the human body. The clinical manifestations of PCOS are similar to some thyroid diseases. Furthermore, some thyroid diseases, such as subclinical hypothyroidism (SCH), not only increase the incidence rate of PCOS, but also exacerbate its associated metabolic abnormalities and reproductive disorders. Interestingly, PCOS also increases the incidence of some thyroid diseases. However, the role of the thyroid in PCOS remains unclear. This review is intended to thoroughly explore the critical role of the thyroid in PCOS by summarizing the comorbidity of PCOS and thyroid diseases and their combined role in metabolic disorders, related metabolic diseases, and reproductive disorders; and by analyzing the potential mechanism through which the thyroid influences the development and progression of PCOS and its symptoms. We hope this review will provide a valuable reference for the role of the thyroid in PCOS.
C1 [Fan, Huanhuan; Ren, Qingling] Nanjing Univ Chinese Med, Affiliated Hosp, Nanjing, Peoples R China.
   [Sheng, Zhejin] Tongji Univ, Sch Life Sci & Technol, Shanghai, Peoples R China.
   [Deng, Ganxiu] Tongji Univ, Sch Med, Shanghai East Hosp, Dept Resp & Crit Care Med, Shanghai, Peoples R China.
   [Li, Limei] Tongji Univ, Shanghai East Hosp, Res Ctr Translat Med, Key Lab Arrhythmias,Minist Educ China,Sch Med, Shanghai, Peoples R China.
C3 Nanjing University of Chinese Medicine; Tongji University; Tongji
   University; Tongji University; Ministry of Education - China
RP Li, LM (corresponding author), Tongji Univ, Shanghai East Hosp, Res Ctr Translat Med, Key Lab Arrhythmias,Minist Educ China,Sch Med, Shanghai, Peoples R China.
EM 13601868653@163.com
FU This study was supported by Diabetes Talent Research Project of China
   International Medical Foundation (2018-N-01-26), the Fundamental
   Research Funds for the Central Universities (1507219059).
   [2018-N-01-26]; Diabetes Talent Research Project of China International
   Medical Foundation [1507219059]; Fundamental Research Funds for the
   Central Universities
FX This study was supported by Diabetes Talent Research Project of China
   International Medical Foundation (2018-N-01-26), the Fundamental
   Research Funds for the Central Universities (1507219059).
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NR 129
TC 16
Z9 16
U1 2
U2 4
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD OCT 5
PY 2023
VL 14
AR 1242050
DI 10.3389/fendo.2023.1242050
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA U8QW5
UT WOS:001087402900001
PM 37867519
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Sharma, RK
   Sharma, MR
   Mahendra, A
   Sharma, U
   Singh, S
   Ramniwas, S
   Sharma, AK
AF Sharma, Ravi Kant
   Sharma, Manu Rashmi
   Mahendra, Aneet
   Sharma, Ujjawal
   Singh, Simranjit
   Ramniwas, Seema
   Sharma, Anil Kumar
TI Artificial Intelligence Bringing Newer Paradigms in the Diagnosis,
   Treatment, and Management of Psoriasis
SO CURRENT DERMATOLOGY REPORTS
LA English
DT Review
DE Psoriasis; Artificial intelligence; Computing technologies; Diagnosis;
   Disease severity; Healthcare
ID SEVERITY INDEX; DEEP; SURFACE; TOOLS; AREA
AB Purpose of Review As we know, psoriasis is the most prevalent chronic inflammatory skin condition due to aberrant immune response which is characterized by clearly demarcated red or pink thick raised skin plaques sometimes covered with dry thin silvery white scales, formed due to the cytokine-driven hyperproliferation of epidermal keratinocytes. The abnormal functioning of immune-inflammatory pathways can cause various systemic conditions including cardiovascular diseases, chronic renal disease, and metabolic syndrome.
   Recent Findings In comparison to other dermatological conditions, psoriasis has greater impact on the mental health of patients leading to increased risk of psychiatric comorbidities such as depression and anxiety. The Articial intellingence could automate the analysis and provide contextual relevance, enhance clinical reliability, assist the clinicians in communicating objectively, minimize human fatigue related errors, decrease mortality rates, save medical expenditures and help in easy and early diagnosis of diseases including psoriasis.
   Summary Therefore, development of better approaches for the diagnosis of psoriasis and determination of its classification type and severity are necessary for disease control and management and are the need of the hour. The artificial intelligence (AI) applications in medicine and healthcare are recently emerging due to advanced computing technologies and availability of abundant data on a variety of diseases including psoriasis. Hence, AI will certainly be a boon for the early detection and management of psoriasis patients necessitating further research in this area.
C1 [Sharma, Ravi Kant] Maharishi Markandeshwar, Dept Biosci & Technol, Ambala 133207, Haryana, India.
   [Sharma, Ravi Kant; Singh, Simranjit] Punjab Univ, Dr Harvansh Singh Judge Inst Dent Sci & Hosp, Chandigarh, India.
   [Sharma, Manu Rashmi] ESI Hosp, Dept Hlth & Planning, Una, Himachal Prades, India.
   [Mahendra, Aneet] Maharishi Markandeshwar, MMIMSR, Dept Dermatol, Ambala 133207, Haryana, India.
   [Sharma, Ujjawal] Cent Univ Punjab, Dept Mol Med, Bathinda, Punjab, India.
   [Ramniwas, Seema] Chandigarh Univ, Univ Ctr Res & Dev, Univ Inst Biotechnol, Mohali, Punjab, India.
   [Sharma, Anil Kumar] Amity Univ, Dept Biotechnol, Sect 82 IT City Rd,Block D, Sahibzada Ajit Singh Naga 140306, Punjab, India.
C3 Panjab University; Maharishi Markandeshwar University; Central
   University of Punjab; Chandigarh University
RP Sharma, AK (corresponding author), Amity Univ, Dept Biotechnol, Sect 82 IT City Rd,Block D, Sahibzada Ajit Singh Naga 140306, Punjab, India.
EM anibiotech18@gmail.com
RI Sharma, Anil/AAP-1909-2020; Singh, Simranjit/LRU-3268-2024; Sharma,
   Ravi/KIL-2877-2024; Sharma, Ujjawal/E-7097-2013
OI Sharma, Anil/0000-0002-9768-1644
FU The authors are thankful to their respective institutes for providing
   the requisite platform to write this manuscript. The authors wish to
   thank Dr. Tej Khaket for reviewing their manuscript.
FX The authors are thankful to their respective institutes for providing
   the requisite platform to write this manuscript. The authors wish to
   thank Dr. Tej Khaket for reviewing their manuscript.
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NR 26
TC 3
Z9 3
U1 1
U2 4
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 2162-4933
J9 CURR DERMATOL REP
JI Curr. Dermatol. Rep.
PD DEC
PY 2023
VL 12
IS 4
BP 314
EP 320
DI 10.1007/s13671-023-00408-6
EA OCT 2023
PG 7
WC Dermatology
WE Emerging Sources Citation Index (ESCI)
SC Dermatology
GA DX7M7
UT WOS:001075100900001
DA 2025-06-11
ER

PT J
AU Tsai, HH
   Yeh, CY
   Su, CT
   Chen, CJ
   Peng, SM
   Chen, RY
AF Tsai, Han Hui
   Yeh, Ching Ying
   Su, Chien Tien
   Chen, Chiou Jong
   Peng, Shu Mei
   Chen, Ruey Yu
TI The Effects of Exercise Program on Burnout and Metabolic Syndrome
   Components in Banking and Insurance Workers
SO INDUSTRIAL HEALTH
LA English
DT Article
DE Exercise intervention; Job stress; Burnout; Metabolic syndrome
   components; Work environment
ID CARDIOVASCULAR-DISEASE RISK; AMBULATORY BLOOD-PRESSURE; WHITE-COLLAR
   WORKERS; PHYSICAL-ACTIVITY; PROSPECTIVE COHORT; PERCEIVED STRESS;
   AEROBIC EXERCISE; CHINESE VERSION; JOB STRAIN; EMPLOYEES
AB To explore the effectiveness of exercise program for banking and insurance workers and clarify the association between exercise, burnout, and metabolic syndrome components. In the process of the study, a practicable worksite exercise program was developed for bank and insurance enterprises. A three-month (12-wk) exercise course was conducted, and its benefits evaluated. Levels of burnout and metabolic syndrome components were analyzed after exercise intervention. After intervention, the indicators of burnout and metabolic syndrome components were significantly improved in both low and high intensity groups, and the improvement were expressed in reduction of waist circumference, systolic blood pressure, person burnout and work-related burnout. A dose-response of burnouts and metabolic syndrome components with exercise intensity are shown (p<0.05). Metabolic syndrome components were independently associated with burnout and exercise intensity in the crude model. After adjustment for potential confounders, waist circumference and systolic blood pressure differences showed significant associations with exercise intensity (p<0.05). This study demonstrated an effective approach to worksite exercise intervention and exercise intensity played an important role to alleviate damage between burnouts and metabolic syndrome components.
C1 [Tsai, Han Hui; Yeh, Ching Ying; Su, Chien Tien; Chen, Chiou Jong; Chen, Ruey Yu] Taipei Med Univ, Sch Publ Hlth, Taipei, Taiwan.
   [Peng, Shu Mei] Chinese Culture Univ, Dept Phys Educ, Taipei, Taiwan.
   [Chen, Chiou Jong] Inst Occupat Safety & Hlth, Council Labor Affairs, Taipei, Taiwan.
C3 Taipei Medical University; Chinese Culture University
RP Chen, RY (corresponding author), Taipei Med Univ, Sch Publ Hlth, Taipei, Taiwan.
EM rueyyu@tmu.edu.tw
RI Chen, Yi-Hsuan/ABF-8054-2020
OI Chen, Chiou-Jong/0000-0003-2997-3597
FU Institute of Occupational Safety and Health, Council of Labor Affairs,
   Executive Yuan, Taiwan
FX The authors wish to thank the Institute of Occupational Safety and
   Health, Council of Labor Affairs, Executive Yuan, Taiwan for providing
   financial support. In addition, we are grateful to the bank and
   insurance workers who participated in our study.
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NR 48
TC 36
Z9 41
U1 5
U2 46
PU NATL INST OCCUPATIONAL SAFETY & HEALTH, JAPAN
PI KAWASAKI KANAGAWA
PA 21-1 NAGAO 6-CHOME TAMA-KU, KAWASAKI KANAGAWA, 214, JAPAN
SN 0019-8366
J9 IND HEALTH
JI Ind. Health
PD MAY
PY 2013
VL 51
IS 3
BP 336
EP 346
PG 11
WC Environmental Sciences; Public, Environmental & Occupational Health;
   Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health; Toxicology
GA 155YO
UT WOS:000319786800011
PM 23518604
OA Bronze
DA 2025-06-11
ER

PT J
AU Sevillano-Jiménez, A
   Romero-Saldaña, M
   García-Mellado, JA
   Carrascal-Laso, L
   García-Rodríguez, M
   Molina-Luque, R
   Molina-Recio, G
AF Sevillano-Jimenez, Alfonso
   Romero-Saldana, Manuel
   Antonio Garcia-Mellado, Juan
   Carrascal-Laso, Lorena
   Garcia-Rodriguez, Maria
   Molina-Luque, Rafael
   Molina-Recio, Guillermo
TI Impact of high prebiotic and probiotic dietary education in the
   SARS-CoV-2 era: improved cardio-metabolic profile in schizophrenia
   spectrum disorders
SO BMC PSYCHIATRY
LA English
DT Article
DE Metabolic Syndrome; Cardiometabolic Risk Factors; Schizophrenia Spectrum
   and Other Psychotic Disorders; Nursing; SARS-CoV-2
ID ATYPICAL ANTIPSYCHOTICS; GUT MICROBIOTA; INTERVENTIONS; PSYCHOBIOTICS;
   ABNORMALITIES; DISEASE; HEALTH; RISK
AB Background: The development of new aetiological premises, such as the microbiota-gut-brain axis theory, evidences the influence of dietary and nutritional patterns on mental health, affecting the patient's quality of life in terms of physical and cardiovascular health. The aim was to determine the impact of a nutritional programme focused on increasing the intake of prebiotic and probiotic food on cardio-metabolic status in individuals with schizophrenia spectrum disorders in the contextual setting of the SARS-CoV-2 era. Methods: A randomised clinical trial (two-arm, double-blind, balanced-block, six-month intervention) was conducted in a group of 50 individuals diagnosed with schizophrenia spectrum disorder during the SARS-CoV-2 confinement period. The control group received conventional dietary counselling on an individual basis. In the intervention group, an individual nutritional education programme with a high content of prebiotics and probiotics (dairy and fermented foods, green leafy vegetables, high-fibre fruit, whole grains, etc.) was established. Data on cardiovascular status were collected at baseline, three and six months. In addition, anthropometric parameters were analysed monthly. Results: Forty-four subjects completed follow-up and were analysed. Statistical differences (p < 0.05) were found in all anthropometric variables at baseline and six months of intervention. A 27.4% reduction in the prevalence of metabolic syndrome risk factors in all its components was evidenced, leading to a clinically significant improvement (decrease in cardiovascular risk) in the intervention group at six months. Conclusions: The development of a nutritional programme focused on increasing the dietary content of prebiotics and probiotics effectively improves the cardio-metabolic profile in schizophrenia spectrum disorders. Therefore, nursing assumes an essential role in the effectiveness of dietary interventions through nutritional education and the promotion of healthy lifestyles. Likewise, nursing acquires a relevant role in interdisciplinary coordination in confinement contexts.
C1 [Sevillano-Jimenez, Alfonso] Reina Sofia Univ Hosp, Montilla Community Mental Hlth Unit, Mental Hlth Clin Management Unit, Andalucia 11, Montilla 14550, Cordoba, Spain.
   [Romero-Saldana, Manuel; Molina-Luque, Rafael; Molina-Recio, Guillermo] Univ Cordoba, Lifestyles Innovat & Hlth GA 16, Dept Nursing Pharmacol & Physiotherapy, Maimonides Biomed Res Inst Cordoba IMIBIC, Avd Menendez Pidal S-N, Cordoba 14004, Spain.
   [Antonio Garcia-Mellado, Juan; Carrascal-Laso, Lorena] Zamora Prov Hosp, Psychiat Serv, Zamora Welf Complex,C Hernan Cortes 40, Zamora 49021, Spain.
   [Garcia-Rodriguez, Maria] European Univ, Biomed Sci & Hlth Fac, Dept Nursing & Nutr, C Tajo S-N, Villaviciosa De Odon 28670, Madrid, Spain.
   [Garcia-Rodriguez, Maria] Maimonides Biomed Res Inst Cordoba IMIBIC, Lifestyles Innovat & Hlth GA 16, Avd Menendez Pidal S-N, Cordoba 14004, Spain.
C3 Universidad de Cordoba
RP Romero-Saldaña, M (corresponding author), Univ Cordoba, Lifestyles Innovat & Hlth GA 16, Dept Nursing Pharmacol & Physiotherapy, Maimonides Biomed Res Inst Cordoba IMIBIC, Avd Menendez Pidal S-N, Cordoba 14004, Spain.
RI Molina-Recio, Guillermo/JRX-8837-2023; Molina-Luque,
   Rafael/HKN-3056-2023; Romero-Saldaña, Manuel/AAA-3456-2020;
   Molina-Luque, Rafael/S-6642-2018
OI Molina-Luque, Rafael/0000-0002-5223-7400; Sevillano Jimenez,
   Alfonso/0000-0001-9809-4380; Garcia Rodriguez, Maria/0000-0003-3592-9146
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TC 10
Z9 10
U1 2
U2 9
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-244X
J9 BMC PSYCHIATRY
JI BMC Psychiatry
PD DEC 12
PY 2022
VL 22
IS 1
AR 781
DI 10.1186/s12888-022-04426-9
PG 12
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychiatry
GA 6Y9DU
UT WOS:000897387600001
PM 36510155
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Cardenas, V
   Mausbach, BT
   Sommerfeld, D
   Jimenez, D
   von Känel, R
   Ho, JS
   Garcia, P
   Aarons, GA
AF Cardenas, Veronica
   Mausbach, Brent T.
   Sommerfeld, David
   Jimenez, Daniel
   von Kanel, Roland
   Ho, Jennifer S.
   Garcia, Piedad
   Aarons, Gregory A.
TI Depression is Associated with Increased Risk for Metabolic Syndrome in
   Latinos with Type 2 Diabetes
SO AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
LA English
DT Article
DE Latino; depression; metabolic syndrome; diabetes; cardiovascular disease
   risk
ID CORONARY-HEART-DISEASE; CAGE QUESTIONNAIRE; CONTROLLED-TRIAL;
   OLDER-ADULTS; HEALTH; METAANALYSIS; PREVALENCE; COMMUNITY; DIVERSE; CARE
AB Objective: Latino adults are 66% more likely to have diabetes relative to non-Latino white adults. Prior research identifies depression as a significant risk factor for metabolic syndrome (MetS), but research examining this among Latinos is lacking. This study sought to examine the links between depression and MetS and clinically significant elevations in cardiovascular disease risk markers of MetS in a sample of community-dwelling older Latinos with type 2 diabetes. Methods: Participants were 332 community-dwelling older (>= 60 years) Latinos with type 2 diabetes who completed the nine-item Patient Health Questionnaire and received a health checkup assessing body mass index (BMI), triglyceride and high-density lipoprotein (HDL) cholesterol levels, and blood pressure. Logistic regression analysis compared MetS rates of those meeting criteria for depression with those who did not. Secondary analyses examined the associations between depression and individual MetS components. All analyses controlled for demographic (e.g., income, age) and other potential MetS risk factors (e.g., smoking status, physical activity, alcohol level consumption). Results: Depression was significantly associated with an increased risk of MetS (OR: 5.79; 95% CI: 1.32-25.42) and clinically significant elevations in triglycerides (OR: 2.71; 95% CI: 1.15-6.42) and reduced (HDL) cholesterol (OR: 2.46; 95% CI: 1.11-5.45). A significant association was not observed between depression and either BMI or hypertension. Conclusion: Depression is significantly linked to MetS, and most notably dyslipidemia, in older Latinos with diabetes. Causation, however, cannot be inferred from these analyses given the cross-sectional nature of the study. Future research should prospectively examine the directionality of this effect.
C1 [Cardenas, Veronica; Mausbach, Brent T.; Sommerfeld, David; Ho, Jennifer S.; Aarons, Gregory A.] Univ Calif San Diego, Dept Psychiat, 9500 Gilman Dr, La Jolla, CA 92093 USA.
   [Jimenez, Daniel] Univ Miami, Miller Sch Med, Dept Psychiat & Behav Sci, Miami, FL 33136 USA.
   [von Kanel, Roland] Klin Barmelweid, Barmelweid, Switzerland.
   [Garcia, Piedad] Cty San Diego Hlth & Human Serv Agcy, Behav Hlth Serv, San Diego, CA USA.
C3 University of California System; University of California San Diego;
   University of Miami
RP Mausbach, BT (corresponding author), Univ Calif San Diego, Dept Psychiat 0680, 9500 Gilman Dr, La Jolla, CA 92093 USA.
EM bmausbach@ucsd.edu
RI von Kanel, Roland/B-1811-2019
OI von Kanel, Roland/0000-0002-8929-5129
FU County of San Diego Behavioral Health Services [530322, K23 MH098025]
FX This work was supported by County of San Diego Behavioral Health
   Services 530322 and grant K23 MH098025 (principle investigator, DJ).
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NR 40
TC 11
Z9 13
U1 0
U2 4
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1064-7481
EI 1545-7214
J9 AM J GERIAT PSYCHIAT
JI Am. J. Geriatr. Psychiatr.
PD JUN
PY 2017
VL 25
IS 6
BP 646
EP 653
DI 10.1016/j.jagp.2017.02.017
PG 8
WC Geriatrics & Gerontology; Gerontology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Psychiatry
GA FA5JH
UT WOS:000405478800013
PM 28341138
OA Green Submitted, Green Accepted
DA 2025-06-11
ER

PT J
AU Pedersen, JM
   Lund, R
   Andersen, I
   Clark, AJ
   Prescott, E
   Rod, NH
AF Pedersen, Jolene Masters
   Lund, Rikke
   Andersen, Ingelise
   Clark, Alice Jessie
   Prescott, Eva
   Rod, Naja Hulvej
TI Psychosocial risk factors for the metabolic syndrome: A prospective
   cohort study
SO INTERNATIONAL JOURNAL OF CARDIOLOGY
LA English
DT Article
DE Stress; Psychosocial factors; Metabolic syndrome; Social network; Major
   life events; Vital exhaustion
ID STRESSFUL LIFE EVENTS; HEART-DISEASE; VITAL EXHAUSTION; WOMEN;
   MORTALITY; SUPPORT; SLEEP
AB Background/Objectives: Metabolic deregulations and development of metabolic syndrome may be an important pathway underlying the relationship between stress and cardiovascular disease. We aim to estimate the effect of a comprehensive range of psychosocial factors on the risk of developing metabolic syndrome in men and women.
   Methods: The study population consisted of 3621 men and women from the Copenhagen City Heart Study who were free of metabolic syndrome at baseline and reexamined after 10 years. The data was analyzed by multivariable logistic regression models adjusted for age, education, income, menopausal status and life style factors.
   Results: We found major life events in adult life (OR 1.48, 95% CI 0.93 to 2.36) and major life events at work (OR 2.75, 95% CI 1.38 to 5.50), lacking a confidant (OR 1.94, 95% CI 1.07 to 3.53) and dissatisfaction with social network (OR 1.53, 95% CI 1.11 to 2.11) to be risk factors for developing the metabolic syndrome in women, while vital exhaustion (OR 2.09, 95% CI 0.95 to 4.59) and intake of sleep medications (OR 2.54, 95% CI 0.92 to 5.96) may play a more important role in men.
   Conclusions: Experiencing major life events in work and adult life and/or dysfunctional social networks is a risk factor for metabolic syndrome in women, and stress reactions such as vital exhaustion and intake of sleep medications may play a more important role in the development of metabolic syndrome men. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
C1 [Pedersen, Jolene Masters; Lund, Rikke; Andersen, Ingelise; Clark, Alice Jessie; Rod, Naja Hulvej] Univ Copenhagen, Inst Publ Hlth, Dept Social Med, Oster Farimagsgade 5,Postbox 2099, DK-1014 Copenhagen K, Denmark.
   [Prescott, Eva] Bispebjerg Hosp, Dept Cardiol, Copenhagen, Denmark.
C3 University of Copenhagen; University of Copenhagen; Copenhagen
   University Hospital; Bispebjerg Hospital
RP Pedersen, JM (corresponding author), Univ Copenhagen, Inst Publ Hlth, Dept Social Med, Oster Farimagsgade 5,Postbox 2099, DK-1014 Copenhagen K, Denmark.
EM jope@sund.ku.dk
RI Lund, Rikke/HJY-7584-2023; Prescott, Eva/AAJ-7441-2020; Rod, Naja
   Hulvej/B-9411-2015
OI PEdersen, Jolene MAsters/0000-0002-7592-422X; Andersen,
   Ingelise/0000-0002-0076-265X; Lund, Rikke/0000-0002-0381-4291; Clark,
   Alice/0000-0003-1369-8017; Prescott, Eva/0000-0002-4134-0349; Rod, Naja
   Hulvej/0000-0002-6400-5105
FU Danish Heart Foundation [09-4-A2481-22530F]; Danish Medical Research
   Council [271-06-0687]
FX This work was supported by the Danish Heart Foundation
   (09-4-A2481-22530F to JPM.); and Danish Medical Research Council
   (271-06-0687 to NHR).
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NR 35
TC 29
Z9 33
U1 0
U2 12
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0167-5273
EI 1874-1754
J9 INT J CARDIOL
JI Int. J. Cardiol.
PD JUL 15
PY 2016
VL 215
BP 41
EP 46
DI 10.1016/j.ijcard.2016.04.076
PG 6
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Cardiovascular System & Cardiology
GA DM4DX
UT WOS:000376297100013
PM 27107545
DA 2025-06-11
ER

PT J
AU Fekedulegn, D
   Andrew, M
   Violanti, J
   Hartley, T
   Charles, L
   Burchfiel, C
AF Fekedulegn, Desta
   Andrew, Michael
   Violanti, John
   Hartley, Tara
   Charles, Luenda
   Burchfiel, Cecil
TI Comparison of Statistical Approaches to Evaluate Factors Associated With
   Metabolic Syndrome
SO JOURNAL OF CLINICAL HYPERTENSION
LA English
DT Article
ID COMMON OUTCOMES; RELATIVE RISK; PREVALENCE; REGRESSION; ADULTS
AB In statistical analyses, metabolic syndrome as a dependent variable is often utilized in a binary form (presence/absence) where the logistic regression model is used to estimate the odds ratio as the measure of association between health-related factors and metabolic syndrome. Since metabolic syndrome is a common outcome the interpretation of odds ratio as an approximation to prevalence or risk ratio is questionable as it may overestimate its intended target. In addition, dichotomizing a variable that could potentially be treated as discrete may lead to reduced statistical power. In this paper, the authors treat metabolic syndrome as a discrete outcome by defining it as the count of syndrome components. The goal of this study is to evaluate the usefulness of alternative generalized linear models for analysis of metabolic syndrome as a count outcome and compare the results with models that utilize the binary form. Empirical data were used to examine the association between depression and metabolic syndrome. Measures of association were calculated using two approaches; models that treat metabolic syndrome as a binary outcome (the logistic, log-binomial, Poisson, and the modified Poisson regression) and models that utilize metabolic syndrome as discrete/count data (the Poisson and the negative binomial regression). The method that treats metabolic syndrome as a count outcome (Poisson/negative binomial regression model) appears more sensitive in that it is better able to detect associations and hence can serve as an alternative to analyze metabolic syndrome as count dependent variable and provide an interpretable measure of association.
C1 [Fekedulegn, Desta; Andrew, Michael; Hartley, Tara; Charles, Luenda; Burchfiel, Cecil] NIOSH, Biostat & Epidemiol Branch, Hlth Effects Lab Div, Ctr Dis Control & Prevent, Morgantown, WV 26505 USA.
   [Violanti, John] SUNY Buffalo, Dept Social & Prevent Med, Buffalo, NY 14260 USA.
C3 Centers for Disease Control & Prevention - USA; National Institute for
   Occupational Safety & Health (NIOSH); State University of New York
   (SUNY) System; University at Buffalo, SUNY
RP Fekedulegn, D (corresponding author), NIOSH, Biostat & Epidemiol Branch, Hlth Effects Lab Div, Ctr Dis Control & Prevent, MS 4050,1095 Willowdale Rd, Morgantown, WV 26505 USA.
EM djf7@cdc.gov
FU National Institute for Occupational Safety and Health (NIOSH)
   [200-2003-01580]
FX This work was supported by the National Institute for Occupational
   Safety and Health (NIOSH), contract no. 200-2003-01580. The findings and
   conclusions in this report are those of the authors and do not
   necessarily represent the views of the NIOSH. No competing financial
   interests exist.
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NR 34
TC 45
Z9 48
U1 0
U2 1
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1524-6175
J9 J CLIN HYPERTENS
JI J. Clin. Hypertens.
PD MAY
PY 2010
VL 12
IS 5
BP 365
EP 373
DI 10.1111/j.1751-7176.2010.00264.x
PG 9
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 591LN
UT WOS:000277302200008
PM 20546380
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Vuong, E
   Nothling, J
   Lombard, C
   Jewkes, R
   Peer, N
   Abrahams, N
   Seedat, S
AF Vuong, E.
   Nothling, J.
   Lombard, C.
   Jewkes, R.
   Peer, N.
   Abrahams, N.
   Seedat, S.
TI Peripheral adiponectin levels in anxiety, mood, trauma- and
   stressor-related disorders: A systematic review and meta-analysis
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Review
DE Adiponectin; Anxiety; Depression; Mood disorders; Post-traumatic stress
   disorder; Trauma
ID MAJOR DEPRESSIVE DISORDER; PITUITARY-ADRENAL AXIS; PLASMA ADIPONECTIN;
   METABOLIC SYNDROME; SERUM ADIPONECTIN; LEPTIN CONCENTRATIONS;
   INSULIN-RESISTANCE; PROINFLAMMATORY MARKERS; PREMENOPAUSAL WOMEN;
   BIPOLAR PATIENTS
AB Background: Anxiety, mood, trauma- and stressor-related disorders confer increased risk for metabolic disease. Adiponectin, a cytokine released by adipose tissue is associated with these disorders and obesity via inflammatory processes. Available data describing associations with mental disorders remain limited and conflicted.
   Methods: A systematic search was conducted for English, peer-reviewed articles from inception until February 2019 that assessed for serum or plasma adiponectin levels in adults with an anxiety, mood or trauma-related disorder. Diagnoses were determined by psychiatric interview, based on DSM-IV, DSM-5 or ICD-10 criteria. Analyses were performed using STATA 15 and Standardized mean difference (SMD) with 95% confidence interval was applied to pool the effect size of meta-analysis studies.
   Results: In total 65 eligible studies were included in the systematic review and 30 studies in this meta-analysis. 19,178 participants (11,262 females and 7916 males), comprising healthy adults and adults with anxiety, mood and trauma-related disorders, were included. Overall results indicated an inverse association between adiponectin levels and examined mental disorders. Specifically, patients with an anxiety disorder (SMD = -1.18 mu g/mL, 95% CI, -2.34; -0.01, p = 0.047); trauma or stressor-related disorder (SMD = -0.34 mu g/mL, 95% CI, - 0.52; - 0.17, p = 0.0000) or bipolar disorder (SMD = - 0.638 mu g/mL, 95% CI, -1.16, - 0.12, p = 0.017) had significant lower adiponectin levels compared to healthy adults.
   Limitations: Heterogeneity, potential publication bias, and lack of control for important potential confounders were significant limitations.
   Conclusion: Peripheral adiponectin levels appear to be inversely associated with anxiety, mood, trauma- and stressor related disorders and may be a promising biomarker for diagnosis and disease monitoring.
C1 [Vuong, E.; Nothling, J.; Seedat, S.] Stellenbosch Univ, Dept Psychiat, PTSD Program, South African Res Chairs Initiat SARChI, Stellenbosch, South Africa.
   [Vuong, E.; Nothling, J.; Seedat, S.] Stellenbosch Univ, Dept Psychiat, Stellenbosch, South Africa.
   [Lombard, C.] South Africa Med Res Council, Biostat Unit, Cape Town, South Africa.
   [Jewkes, R.; Abrahams, N.] South African Med Res Council, Gender & Hlth Res Unit, Tygerberg, South Africa.
   [Peer, N.] South African Med Res Council, Noncommunicable Dis Res Unit, Durban, South Africa.
C3 Stellenbosch University; Stellenbosch University; South African Medical
   Research Council; South African Medical Research Council
RP Vuong, E (corresponding author), Stellenbosch Univ, Dept Psychiat, POB 241, ZA-8000 Cape Town, South Africa.
EM eileenthomas@sun.ac.za
RI Nöthling, Jani/ACT-7530-2022; Abrahams, Naeemah/JAN-9361-2023
OI Peer, Nasheeta/0000-0003-2131-8344; Abrahams,
   Naeemah/0000-0002-6138-6256; Jewkes, Rachel/0000-0002-4330-6267; Seedat,
   Soraya/0000-0002-5118-786X
FU Medical Research Council of South Africa [SAMRC-RFA-IFSP-01-2013/RAPE
   COHORT]
FX This research did not receive any specific grant from funding agencies
   in the public, commercial, or not-for-profit sectors. Funding provided
   by the Medical Research Council of South Africa in terms of the MRC's
   Flagships Awards Project SAMRC-RFA-IFSP-01-2013/RAPE COHORT.
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NR 118
TC 28
Z9 30
U1 1
U2 58
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD JAN 1
PY 2020
VL 260
BP 372
EP 409
DI 10.1016/j.jad.2019.09.050
PG 38
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA JE1BQ
UT WOS:000490428300050
PM 31539673
DA 2025-06-11
ER

PT J
AU Balasubramanyam, A
   Hinnen, D
   Polonsky, W
AF Balasubramanyam, Ashok
   Hinnen, Deborah
   Polonsky, William
TI Cardiovascular event prevention in the person with type 2 diabetes -
   Case examples for identifying and treating multiple risks
SO DIABETES EDUCATOR
LA English
DT Article
ID CORONARY-HEART-DISEASE; METABOLIC SYNDROME; GLYCEMIC CONTROL;
   BLOOD-PRESSURE; DEPRESSION; METFORMIN; INSULIN; PATHOPHYSIOLOGY;
   PIOGLITAZONE; ASSOCIATION
C1 Baylor Coll Med, Houston, TX 77030 USA.
   Via Christi Hlth Syst, Wichita, KS USA.
   Univ Calif San Diego, San Diego, CA 92103 USA.
C3 Baylor College of Medicine; University of California System; University
   of California San Diego
RP Balasubramanyam, A (corresponding author), Baylor Coll Med, 1 Baylor Plaza,Room 719E, Houston, TX 77030 USA.
EM ashokb@bcm.tcu.edu
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   2005, ATP 3 CORONARY HEART
NR 53
TC 0
Z9 0
U1 0
U2 1
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0145-7217
EI 1554-6063
J9 DIABETES EDUCATOR
JI Diabetes Educ.
PD JUL-AUG
PY 2006
VL 32
SU 5
BP 163S
EP 173S
DI 10.1177/0145721706291304
PG 11
WC Endocrinology & Metabolism; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Public, Environmental & Occupational Health
GA 069IG
UT WOS:000239439000001
PM 16873585
DA 2025-06-11
ER

PT J
AU Tselmin, S
   Korenblum, W
   Reimann, M
   Bornstein, SR
   Schwarz, PEH
AF Tselmin, S.
   Korenblum, W.
   Reimann, M.
   Bornstein, S. R.
   Schwarz, P. E. H.
TI The health status of Russian-speaking immigrants in Germany
SO HORMONE AND METABOLIC RESEARCH
LA English
DT Review
DE Russian-speaking immigrants; German resettlers; jewisch refugees; health
   care; lipid metabolism; mental health
ID FORMER SOVIET-UNION; TYPE-2 DIABETES RISK; METABOLIC SYNDROME; ADIPOQ
   GENE; HEPATITIS-B; PREVENTION; POPULATION; IMPLEMENTATION; MORTALITY;
   PROMOTER
AB Introduction: Germany developed today into a country of immigration, which creates an additional burden for the social security system and results in a new challenge for the healthcare. In the last 17 years more than two million "Russia Germans" have been repatriated and about two hundred thousand Jewish refugees have resettled in Germany from the former Soviet Union. Nevertheless relevant data concerning migration-related public health care are very scare.
   Methods: Search of PubMed and journals extracts combined with the own researches, analysing the health status indices of the Russian-speaking immigrants in Germany.
   Results: Both repatriates of German origin and Jewish refugees demonstrated higher prevalence of impaired lipid metabolism in comparison with native population. 42% of the 503,040 HBsAg (hepatitis B s-Antigen) carriers in Germany were migrants. The Jewish refugees demonstrated the highest rates of depression and anxiety and the highest levels of awakening cortisol. On the other side German resettlers showed lower cardiovascular as well as all-cause death rates compared to the native Germans.
   Conclusion: The development of adequate health care programmes to address migratory aspects as well as the establishment of quality standards will realistically enhance the capability of responding rapidly to migrant health aspects and help to tackle inequalities in health.
C1 [Tselmin, S.; Korenblum, W.; Reimann, M.; Bornstein, S. R.; Schwarz, P. E. H.] Tech Univ Dresden, Med Fac Carl Gustav Carus, Med Clin 3, Dept Med 3, D-01309 Dresden, Germany.
C3 Technische Universitat Dresden; Carl Gustav Carus University Hospital
RP Schwarz, PEH (corresponding author), Tech Univ Dresden, Med Fac Carl Gustav Carus, Med Clin 3, Dept Med 3, Bldg 10,Room 108,Fetscherstr 74, D-01309 Dresden, Germany.
EM peter.schwarz@uniklinikum-dresden.de
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NR 46
TC 23
Z9 23
U1 0
U2 19
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0018-5043
EI 1439-4286
J9 HORM METAB RES
JI Horm. Metab. Res.
PD DEC
PY 2007
VL 39
IS 12
BP 858
EP 861
DI 10.1055/s-2007-993153
PG 4
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 251GL
UT WOS:000252360500002
PM 18075968
DA 2025-06-11
ER

PT J
AU Stafeev, IS
   Menshikov, MY
   Tsokolaeva, ZI
   Shestakova, MV
   Parfyonova, YV
AF Stafeev, I. S.
   Menshikov, M. Y.
   Tsokolaeva, Z. I.
   Shestakova, M. V.
   Parfyonova, Ye. V.
TI Molecular mechanisms of latent inflammation in metabolic syndrome.
   Possible role of sirtuins and peroxisome proliferator-activated receptor
   type γ
SO BIOCHEMISTRY-MOSCOW
LA English
DT Review
DE metabolic syndrome; inflammation; NF-kappa B; peroxisome
   proliferator-activated receptor type gamma; sirtuins
ID NF-KAPPA-B; ENDOPLASMIC-RETICULUM STRESS; ADIPOSE-TISSUE MACROPHAGES;
   INSULIN-RESISTANCE; DIETARY-FAT; OBESITY; HYPOXIA; SIRT1; CANCER;
   DIFFERENTIATION
AB The problem of metabolic syndrome is one of the most important in medicine today. The main hazard of metabolic syndrome is development of latent inflammation in adipose tissue, which promotes atherosclerosis, non-alcoholic fatty liver disease, myocarditis, and a number of other illnesses. Therefore, understanding of molecular mechanisms of latent inflammation in adipose tissue is very important for treatment of metabolic syndrome. Three main components that arise during hypertrophy and hyperplasia of adipocytes underlie such inflammation: endoplasmic reticulum stress, oxidative stress, and hypoxia. Each of these components mediates activation in different ways of the key factor of inflammation-NF-kappa B. For metabolic syndrome therapy, it is suggested to influence a number of inflammatory signaling components by activating other cell factors to suppress development of inflammation. Such potential factors are peroxisome proliferator-activated receptors type gamma that suppress transcription factor NF-kappa B through direct contact or via kinase of a NF-kappa B inhibitor (IKK), and also the antiinflammatory transcription factor AP-1. Other possible targets are type 3 NAD(+)-dependent histone deacetylases (sirtuins). There are mutually antagonistic relationships between NF-kappa B and sirtuin type 1 that prevent development of inflammation in metabolic syndrome. Moreover, sirtuin type 1 inhibits the antiinflammatory transcription factor AP-1. Study of the influence of these factors on the relationship between macrophages and adipocytes, macrophages, and adipose tissue-derived stromal cells can help to understand mechanisms of signaling and development of latent inflammation in metabolic syndrome.
C1 [Stafeev, I. S.; Menshikov, M. Y.; Tsokolaeva, Z. I.; Parfyonova, Ye. V.] Inst Expt Cardiol, Moscow 121552, Russia.
   [Stafeev, I. S.; Parfyonova, Ye. V.] Moscow MV Lomonosov State Univ, Fac Basic Med, Moscow 119192, Russia.
   [Shestakova, M. V.] Inst Diabet Endocrinol & Metab Dis, Endocrinol Res Ctr, Moscow 117031, Russia.
   [Shestakova, M. V.] Sechenov 1st Moscow State Med Univ, Moscow 119992, Russia.
C3 National Medical Research Center of Cardiology; Lomonosov Moscow State
   University; Russian Academy of Medical Sciences; Endocrinology Research
   Centre
RP Stafeev, IS (corresponding author), Inst Expt Cardiol, Russian Cardiol Res & Prod Complex, Moscow 121552, Russia.
EM yuristafeev@gmail.com
RI Stafeev, Iurii/O-2949-2015; Menshikov, Mikhail/A-9291-2014; Parfyonova,
   Yelena/B-9307-2014; Shestakova, Marina V./D-9123-2012
OI Stafeev, Iurii/0000-0003-3514-3936; Parfyonova,
   Yelena/0000-0002-0969-5780; Shestakova, Marina V./0000-0002-5057-127X;
   Men'sikov, Mihail/0000-0002-9949-0534
FU Russian Foundation for Basic Research [13-04-02014, 15-04-07840];
   Russian Ministry of Health
FX This work was supported by the Russian Foundation for Basic Research
   (projects Nos. 13-04-02014 and 15-04-07840) and by grant of the Russian
   Ministry of Health "Mechanisms of Paracrine and Vessel Stabilizing
   Effects of Stem Cells in Regeneration of Ischemic Tissues and Organs".
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NR 69
TC 15
Z9 16
U1 0
U2 5
PU MAIK NAUKA/INTERPERIODICA/SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013-1578 USA
SN 0006-2979
EI 1608-3040
J9 BIOCHEMISTRY-MOSCOW+
JI Biochem.-Moscow
PD OCT
PY 2015
VL 80
IS 10
BP 1217
EP 1226
DI 10.1134/S0006297915100028
PG 10
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA CT7WU
UT WOS:000363026400002
PM 26567565
DA 2025-06-11
ER

PT J
AU Ratku, B
   Sebestyén, V
   Erdei, A
   Nagy, E
   Szabó, Z
   Somodi, S
AF Ratku, Balazs
   Sebestyen, Veronika
   Erdei, Annamaria
   Nagy, Endre, V
   Szabo, Zoltan
   Somodi, Sandor
TI Effects of adult growth hormone deficiency and replacement therapy on
   the cardiometabolic risk profile
SO PITUITARY
LA English
DT Article
DE Growth hormone deficiency; Cardiometabolic risk; Growth hormone
   replacement therapy; Premature atherosclerosis
ID INTIMA-MEDIA THICKNESS; ONSET GH DEFICIENCY; HEART-RATE-VARIABILITY;
   PLASMA PROTEIN-A; TP-E/QT RATIO; NONFUNCTIONING PITUITARY-ADENOMA;
   PLASMINOGEN-ACTIVATOR INHIBITOR; CARDIOVASCULAR-DISEASE RISK; BASE-LINE
   CHARACTERISTICS; CAROTID-ARTERY INTIMA
AB Adult growth hormone deficiency (AGHD) is considered a rare endocrine disorder involving patients with childhood-onset and adult-onset growth hormone deficiency (AoGHD) and characterized by adverse cardiometabolic risk profile. Besides traditional cardiovascular risk factors, endothelial dysfunction, low-grade inflammation, impaired adipokine profile, oxidative stress and hypovitaminosis D may also contribute to the development of premature atherosclerosis and higher cardiovascular risk in patients with AGHD. Growth hormone replacement has been proved to exert beneficial effects on several cardiovascular risk factors, but it is also apparent that hormone substitution in itself does not eliminate all cardiometabolic abnormalities associated with the disease. Novel biomarkers and diagnostic techniques discussed in this review may help to evaluate individual cardiovascular risk and identify patients with adverse cardiometabolic risk profile. In the absence of disease-specific guidelines detailing how to assess the cardiovascular status of these patients, we generally recommend close follow-up of the cardiovascular status as well as low threshold for a more detailed evaluation.
C1 [Ratku, Balazs; Sebestyen, Veronika; Szabo, Zoltan; Somodi, Sandor] Univ Debrecen, Fac Med, Dept Emergency Med, Egyet Ter 1, H-4032 Debrecen, Hungary.
   [Ratku, Balazs; Sebestyen, Veronika] Univ Debrecen, Doctoral Sch Hlth Sci, Debrecen, Hungary.
   [Ratku, Balazs] Univ Debrecen, Fac Hlth, Dept Emergency & Oxyol, Debrecen, Hungary.
   [Erdei, Annamaria; Nagy, Endre, V; Somodi, Sandor] Univ Debrecen, Fac Med, Dept Internal Med, Div Endocrinol, Debrecen, Hungary.
C3 University of Debrecen; University of Debrecen; University of Debrecen;
   University of Debrecen
RP Somodi, S (corresponding author), Univ Debrecen, Fac Med, Dept Emergency Med, Egyet Ter 1, H-4032 Debrecen, Hungary.; Somodi, S (corresponding author), Univ Debrecen, Fac Med, Dept Internal Med, Div Endocrinol, Debrecen, Hungary.
EM somodi.s.dr@gmail.com
RI Erdei, Annamaria/AAL-5765-2020; Ratku, Balazs/LXW-3225-2024
OI Ratku, Balazs/0000-0002-0991-8622; Somodi, Sandor/0000-0002-3615-2300
FU University of Debrecen [GINOP-2.3.2-15-2016-00005]
FX Open access funding provided by University of Debrecen. The work was
   supported by the GINOP-2.3.2-15-2016-00005.
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NR 185
TC 20
Z9 20
U1 0
U2 4
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1386-341X
EI 1573-7403
J9 PITUITARY
JI Pituitary
PD APR
PY 2022
VL 25
IS 2
BP 211
EP 228
DI 10.1007/s11102-022-01207-1
EA FEB 2022
PG 18
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA ZM1DU
UT WOS:000749463200001
PM 35106704
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Brouwer, JMJL
   Wardenaar, KJ
   Liemburg, EJ
   Doornbos, B
   Mulder, H
   Cath, DC
AF Brouwer, Jurriaan M. J. L.
   Wardenaar, Klaas J.
   Liemburg, Edith J.
   Doornbos, Bennard
   Mulder, Hans
   Cath, Danielle C.
TI High persistence and low treatment rates of metabolic syndrome in
   patients with mood and anxiety disorders: A naturalistic follow-up study
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Metabolic syndrome; Treatment; Mood disorders; Anxiety disorders;
   Outpatient
ID CARDIOVASCULAR RISK-FACTORS; MAJOR DEPRESSIVE DISORDER; BIPOLAR
   DISORDER; LIFE-STYLE; PROSPECTIVE ASSOCIATIONS; PSYCHOTIC DISORDERS;
   CIGARETTE-SMOKING; PHYSICAL ILLNESS; BLOOD-PRESSURE; METAANALYSIS
AB Background: Patients with affective and anxiety disorders are at risk of metabolic syndrome (MetS) and, consequently, cardiovascular disease and premature death. In this study, the course and treatment of MetS was investigated using longitudinal data from a naturalistic sample of affective- and anxiety-disordered outpatients (Monitoring Outcome of psychiatric PHARmacotherapy [MOPHAR]). Methods: Demographics, clinical characteristics, medication use, and MetS components were obtained for n = 2098 patients at baseline and, in a FU-subsample of n = 507 patients, after a median follow-up (FU) of 11 months. Furthermore, pharmacological treatment rates of MetS were investigated at baseline and FU. Finally, demographic and clinical determinants of change in MetS (component) scores were investigated. Results: At baseline, 34.6 % of n = 2098 patients had MetS, 41.4 % of whom received treatment. Of patients with persisting MetS, 46.1 % received treatment for one (or more) MetS component(s) at baseline, and 56.6 % received treatment at FU. Treatment rates of solely elevated blood pressure and reduced HDL-cholesterol did significantly, but modestly, improve. Higher age, male sex, smoking behavior, low education, diabetes, and depressive versus anxiety disorder were predictors of worse outcome at FU on at least one MetS component. Limitations: We did not have data on lifestyle interventions as a form of treatment, which might partly have explained the observed low pharmacotherapeutic treatment rates. Conclusion: MetS (components) show high persistence rates in affective- and anxiety-disordered patients, and are, despite adequate monitoring, undertreated over time. This indicates that adherence and implementation of monitoring protocols should be crucially improved in psychiatric outpatients in secondary care.
C1 [Brouwer, Jurriaan M. J. L.; Mulder, Hans] Wilhelmina Hosp Assen, Dept Clin Pharm, Assen, Netherlands.
   [Brouwer, Jurriaan M. J. L.; Wardenaar, Klaas J.; Liemburg, Edith J.; Cath, Danielle C.] GGZ Drenthe, Mental Hlth Serv, Assen, Netherlands.
   [Cath, Danielle C.] Univ Groningen, Univ Med Ctr Groningen, Res Sch Behav & Cognit Neurosci, Groningen, Netherlands.
   [Wardenaar, Klaas J.] Univ Groningen, Univ Med Ctr Groningen, Interdisciplinary Ctr Psychopathol & Emot Regulat, Dept Psychiat, Groningen, Netherlands.
   [Wardenaar, Klaas J.] Univ Groningen, Fac Behav & Social Sci, Groningen, Netherlands.
   [Liemburg, Edith J.; Cath, Danielle C.] Univ Groningen, Univ Med Ctr Groningen, Rob Giel Res Ctr, Groningen, Netherlands.
   [Doornbos, Bennard] Lentis Res, Lentis Psychiat Inst, Groningen, Netherlands.
   [Brouwer, Jurriaan M. J. L.] Martini Hosp Groningen, Dept Clin Pharm, Swietenlaan 1, NL-9728 NT Groningen, Netherlands.
C3 University of Groningen; University of Groningen; University of
   Groningen; University of Groningen; Martini Hospital
RP Brouwer, JMJL (corresponding author), Martini Hosp Groningen, Dept Clin Pharm, Swietenlaan 1, NL-9728 NT Groningen, Netherlands.
EM jurriaan.brouwer@mzh.nl
RI Wardenaar, Klaas/E-2985-2013
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NR 104
TC 2
Z9 2
U1 6
U2 12
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD JUN 1
PY 2024
VL 354
BP 451
EP 462
DI 10.1016/j.jad.2024.03.042
EA MAR 2024
PG 12
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA PV8E5
UT WOS:001216941700001
PM 38494132
OA hybrid
DA 2025-06-11
ER

PT J
AU Onyango, AN
AF Onyango, Arnold N.
TI Cellular Stresses and Stress Responses in the Pathogenesis of Insulin
   Resistance
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Review
ID NF-KAPPA-B; ENDOPLASMIC-RETICULUM STRESS; PROLIFERATOR-ACTIVATED
   RECEPTOR; NITRIC-OXIDE SYNTHASE; PROTEIN-KINASE-C; HIGH-FAT DIET; NLRP3
   INFLAMMASOME ACTIVATION; RENIN-ANGIOTENSIN SYSTEM; SMOOTH-MUSCLE-CELLS;
   THIOREDOXIN-INTERACTING PROTEIN
AB Insulin resistance (IR), a key component of the metabolic syndrome, precedes the development of diabetes, cardiovascular disease, and Alzheimer's disease. Its etiological pathways are not well defined, although many contributory mechanisms have been established. This article summarizes such mechanisms into the hypothesis that factors like nutrient overload, physical inactivity, hypoxia, psychological stress, and environmental pollutants induce a network of cellular stresses, stress responses, and stress response dysregulations that jointly inhibit insulin signaling in insulin target cells including endothelial cells, hepatocytes, myocytes, hypothalamic neurons, and adipocytes. The insulin resistance-inducing cellular stresses include oxidative, nitrosative, carbonyl/electrophilic, genotoxic, and endoplasmic reticulum stresses; the stress responses include the ubiquitin-proteasome pathway, the DNA damage response, the unfolded protein response, apoptosis, inflammasome activation, and pyroptosis, while the dysregulated responses include the heat shock response, autophagy, and nuclear factor erythroid-2-related factor 2 signaling. Insulin target cells also produce metabolites that exacerbate cellular stress generation both locally and systemically, partly through recruitment and activation of myeloid cells which sustain a state of chronic inflammation. Thus, insulin resistance may be prevented or attenuated by multiple approaches targeting the different cellular stresses and stress responses.
C1 [Onyango, Arnold N.] Jomo Kenyatta Univ Agr & Technol, Dept Food Sci & Technol, POB 62000, Nairobi 00200, Kenya.
C3 Jomo Kenyatta University of Agriculture & Technology
RP Onyango, AN (corresponding author), Jomo Kenyatta Univ Agr & Technol, Dept Food Sci & Technol, POB 62000, Nairobi 00200, Kenya.
EM arnold.onyango@jkuat.ac.ke
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NR 413
TC 97
Z9 103
U1 1
U2 20
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PY 2018
VL 2018
AR 4321714
DI 10.1155/2018/4321714
PG 27
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA GO2IC
UT WOS:000439791900001
PM 30116482
OA Green Published, hybrid, Green Submitted
DA 2025-06-11
ER

PT J
AU de la Fuente-Tomas, L
   Arranz, B
   Safont, G
   Sierra, P
   Sanchez-Autet, M
   Garcia-Blanco, A
   Garcia-Portilla, MP
AF de la Fuente-Tomas, Lorena
   Arranz, Belen
   Safont, Gemma
   Sierra, Pilar
   Sanchez-Autet, Monica
   Garcia-Blanco, Ana
   Garcia-Portilla, Maria P.
TI Classification of patients with bipolar disorder using k-means
   clustering
SO PLOS ONE
LA English
DT Article
ID VS. LATE-STAGE; METABOLIC SYNDROME; SPANISH VERSIONS; QUALITY; MODEL;
   DEPRESSION; ILLNESS; RELIABILITY; COGNITION
AB Introduction
   Bipolar disorder (BD) is a heterogeneous disorder needing personalized and shared decisions. We aimed to empirically develop a cluster-based classification that allocates patients according to their severity for helping clinicians in these processes.
   Methods
   Naturalistic, cross-sectional, multicenter study. We included 224 subjects with BD (DSM-IV-TR) under outpatient treatment from 4 sites in Spain. We obtained information on sociodemography, clinical course, psychopathology, cognition, functioning, vital signs, anthropometry and lab analysis. Statistical analysis: k-means clustering, comparisons of between group variables, and expert criteria.
   Results and discussion
   We obtained 12 profilers from 5 life domains that classified patients in five clusters. The profilers were: Number of hospitalizations and of suicide attempts, comorbid personality disorder, body mass index, metabolic syndrome, the number of comorbid physical illnesses, cognitive functioning, being permanently disabled due to BD, global and leisure time functioning, and patients' perception of their functioning and mental health. We obtained preliminary evidence on the construct validity of the classification: (1) all the profilers behaved correctly, significantly increasing in severity as the severity of the clusters increased, and (2) more severe clusters needed more complex pharmacological treatment.
   Conclusions
   We propose a new, easy-to-use, cluster-based severity classification for BD that may help clinicians in the processes of personalized medicine and shared decision-making.
C1 [de la Fuente-Tomas, Lorena; Arranz, Belen; Safont, Gemma; Garcia-Portilla, Maria P.] Fondos FEDER, Ctr Invest Biomed Red Salud Mental CIBERSAM, Inst Salud Carlos III, Madrid, Spain.
   [de la Fuente-Tomas, Lorena; Garcia-Portilla, Maria P.] Univ Oviedo, Dept Psychiat, Oviedo, Spain.
   [Arranz, Belen; Sanchez-Autet, Monica] Parc Sanitari St Joan Deu, Barcelona, Spain.
   [Arranz, Belen; Safont, Gemma; Sanchez-Autet, Monica] Univ Barcelona, Barcelona, Spain.
   [Safont, Gemma] Univ Hosp Mutua Terrassa, Barcelona, Spain.
   [Sierra, Pilar; Garcia-Blanco, Ana] La Fe Univ & Polytech Hosp, Valencia, Spain.
   [Sierra, Pilar; Garcia-Blanco, Ana] Univ Valencia, Valencia, Spain.
C3 Instituto de Salud Carlos III; CIBER - Centro de Investigacion Biomedica
   en Red; CIBERSAM; University of Oviedo; University of Barcelona;
   Hospital Universitario Mutua Terrassa; University of Valencia
RP Garcia-Portilla, MP (corresponding author), Fondos FEDER, Ctr Invest Biomed Red Salud Mental CIBERSAM, Inst Salud Carlos III, Madrid, Spain.; Garcia-Portilla, MP (corresponding author), Univ Oviedo, Dept Psychiat, Oviedo, Spain.
EM albert@uniovi.es
RI Sanchez, Monica/ABI-6419-2020; de la Fuente-Tomás, Lorena/O-6300-2018;
   Garcia-Blanco, Ana C./I-1928-2017; Garcia-Portilla, Paz/AAC-8272-2020
OI de la Fuente-Tomas, Lorena/0000-0001-8220-5007; Safont,
   Gemma/0000-0001-5122-9161; Garcia-Blanco, Ana C./0000-0002-7840-000X;
   Garcia-Portilla, Paz/0000-0003-3643-1622; Sanchez-Autet,
   Monica/0000-0003-1349-9042; Arranz, Belen/0000-0003-3927-8803
FU Instituto de Salud Carlos III, Spanish Ministry of Economy and
   Competitiveness [FIS PI11/02493]; Fondos Europeos de Desarrollo Regional
   (FEDER); Principado de Asturias Goberment
FX This research was supported by grant FIS PI11/02493 (PI: Maria Paz
   Garcia-Portilla) of the Instituto de Salud Carlos III, Spanish Ministry
   of Economy and Competitiveness and Fondos Europeos de Desarrollo
   Regional (FEDER). Lorena de la Fuente-Tomas has received a Severo Ochoa
   grant supported by Principado de Asturias Goberment. The funders had no
   role in study design, data collection and analysis, decision to publish,
   or preparation of the manuscript.
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NR 58
TC 28
Z9 30
U1 0
U2 7
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JAN 23
PY 2019
VL 14
IS 1
AR e0210314
DI 10.1371/journal.pone.0210314
PG 15
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Science & Technology - Other Topics
GA HI4TC
UT WOS:000456442800039
PM 30673717
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Abbasloo, F
   Ebrahimi, P
   Ghadimi, D
   Sharifi, F
   Ayati, A
   Moodi, M
   Khorashadizadeh, M
   Fakhrzadeh, H
   Zadeh, AZ
   Ramezani, P
   Pirdehghan, R
   Nooraeen, S
   Moradi, A
   Payab, M
   Ebrahimpur, M
AF Abbasloo, Faezeh
   Ebrahimi, Pouya
   Ghadimi, Delaram
   Sharifi, Farshad
   Ayati, Arian
   Moodi, Mitra
   Khorashadizadeh, Masoumeh
   Fakhrzadeh, Hosein
   Zadeh, Amin Zaki
   Ramezani, Pedram
   Pirdehghan, Reza
   Nooraeen, Sara
   Moradi, Ali
   Payab, Moloud
   Ebrahimpur, Mahbube
TI The evaluation of depression prevalence and its association with obesity
   phenotypes in a community-dwelling aged population
SO AGING CLINICAL AND EXPERIMENTAL RESEARCH
LA English
DT Article
DE Aging; Depression; Metabolic syndrome; Mood disorders; Obesity
ID MINI NUTRITIONAL ASSESSMENT; LATE-LIFE DEPRESSION; OLDER-ADULTS;
   METABOLIC SYNDROME; SOCIOECONOMIC-STATUS; ELDERLY POPULATION; MAJOR
   DEPRESSION; SYMPTOMS; HEALTH; PREDICTORS
AB BackgroundDepression is one of the most debilitating mental disorders and a risk factor for many other chronic diseases that are commonly seen in the geriatric population. It has been claimed in previous studies that depression can be associated with obesity in this age group, but there is no common consensus between their results.AimThis study aims to evaluate the association between depression metabolic syndrome and obesity phenotypes in community-dwelling older adults living in the East of Iran.Method and materialsAs a part of the Birjand Longitudinal Aging Study, this retrospective cross-sectional study was conducted on participants older than 60. They were categorized based on their body mass index and components of metabolic syndrome into four phenotypes: metabolic non-healthy obese (MNHO), metabolic healthy obese (MHO), metabolic healthy non-obese (MHNO), and metabolic non-healthy non-obese (MNHNO). The relative risk ratio (RRR) of the obesity phenotypes, the severity of depressive symptoms, and the 95% confidence intervals (95% CI) were evaluated by univariate and multinomial logistic regression.ResultsOf 1344 eligible participants, 268 (19.94%) had depression. Moderate, moderate-severe, and severe depression were observed in 179 (13.32%), 67 (4.99%), and 22 (1.64%) participants, respectively. Our findings showed a non-significant increase in the RRR of mild depressive symptoms in MNHO (RRR:1.22, 95% CI 0.56-2.66) and severe symptoms in MNHNO (RRR:1.20, 95% CI 0.02-63.17) females. However, in male participants, the RRR of moderate-severe depressive symptoms only increased non-significantly for the MNHO category (RRR:1.34, 95% CI 0.45-3.98).ConclusionWe did not observe a meaningful association between depressive symptoms and obesity phenotypes. Also, other than malnutrition or its risk, various severities of depressive symptoms correlate with different sociodemographic and medical risk factors among male and female senior citizens.
C1 [Abbasloo, Faezeh; Ebrahimpur, Mahbube] Univ Tehran Med Sci, Endocrinol & Metab Res Inst, Fac Med, Tehran, Iran.
   [Ebrahimi, Pouya; Ayati, Arian; Ramezani, Pedram; Payab, Moloud] Univ Tehran Med Sci, Endocrinol & Metab Populat Sci Inst, Noncommunicable Dis Res Ctr, First Floor,10,Jalal Al Ahmad St,North Kargar Ave, Tehran 1411713137, Iran.
   [Ghadimi, Delaram; Pirdehghan, Reza] Shahid Beheshti Univ Med Sci, Fac Med, Tehran, Iran.
   [Sharifi, Farshad; Moodi, Mitra; Fakhrzadeh, Hosein; Ebrahimpur, Mahbube] Univ Tehran Med Sci, Endocrinol & Metab Populat Sci Inst, Elderly Hlth Res Ctr, First Floor,10,Jalal Al Ahmad St,North Kargar Ave, Tehran 1411713137, Iran.
   [Khorashadizadeh, Masoumeh] Birjand Univ Med Sci, Social Determinants Hlth Res Ctr, Birjand, Iran.
   [Zadeh, Amin Zaki] Ahwaz Jundishapur Univ Med Sci, Fac Med, Ahwaz, Iran.
   [Pirdehghan, Reza] George Brown Coll, Hlth & Wellness Dept, Toronto, ON, Canada.
   [Nooraeen, Sara] Univ Pittsburgh, Dept Psychiat, Pittsburgh, PA USA.
   [Moradi, Ali] Semmelweis Univ, Fac Med, Ctr Translat Med, Budapest, Hungary.
C3 Tehran University of Medical Sciences; Tehran University of Medical
   Sciences; Shahid Beheshti University Medical Sciences; Tehran University
   of Medical Sciences; Birjand University of Medical Sciences; Ahvaz
   Jundishapur University of Medical Sciences (AJUMS); George Brown
   College; Pennsylvania Commonwealth System of Higher Education (PCSHE);
   University of Pittsburgh; Semmelweis University
RP Ebrahimpur, M (corresponding author), Univ Tehran Med Sci, Endocrinol & Metab Res Inst, Fac Med, Tehran, Iran.; Payab, M (corresponding author), Univ Tehran Med Sci, Endocrinol & Metab Populat Sci Inst, Noncommunicable Dis Res Ctr, First Floor,10,Jalal Al Ahmad St,North Kargar Ave, Tehran 1411713137, Iran.; Ebrahimpur, M (corresponding author), Univ Tehran Med Sci, Endocrinol & Metab Populat Sci Inst, Elderly Hlth Res Ctr, First Floor,10,Jalal Al Ahmad St,North Kargar Ave, Tehran 1411713137, Iran.
EM mpayab@tums.ac.ir; m-ebrahimpur@tums.ac.ir
RI , Mahbube/AAK-3728-2020; Moradi, Ali/AAV-9313-2021; Ebrahimi,
   Pouya/JMQ-6330-2023; Moodi, Mitra/G-8162-2017
FU Endocrine and Metabolism Research Institute of Tehran University of
   Medical Sciences
FX The funding was provided by the Endocrine and Metabolism Research
   Institute of Tehran University of Medical Sciences
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NR 73
TC 1
Z9 1
U1 5
U2 5
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1594-0667
EI 1720-8319
J9 AGING CLIN EXP RES
JI Aging Clin. Exp. Res.
PD DEC 21
PY 2024
VL 37
IS 1
AR 2
DI 10.1007/s40520-024-02904-6
PG 18
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA P9T3L
UT WOS:001381235900001
PM 39708254
OA hybrid
DA 2025-06-11
ER

PT J
AU Rollo, S
   Fraser, BJ
   Seguin, N
   Sampson, M
   Lang, JJ
   Tomkinson, GR
   Tremblay, MS
AF Rollo, Scott
   Fraser, Brooklyn J.
   Seguin, Nick
   Sampson, Margaret
   Lang, Justin J.
   Tomkinson, Grant R.
   Tremblay, Mark S.
TI Health-Related Criterion-Referenced Cut-Points for Cardiorespiratory
   Fitness Among Youth: A Systematic Review
SO SPORTS MEDICINE
LA English
DT Review
ID CARDIOVASCULAR-DISEASE RISK; SHUTTLE RUN PERFORMANCE; AEROBIC FITNESS;
   PHYSICAL-FITNESS; CARDIOMETABOLIC RISK; METABOLIC RISK; MENTAL-HEALTH;
   CHILDREN; ADOLESCENTS; STANDARDS
AB Background Cardiorespiratory fitness (CRF), which reflects the overall aerobic capacity of the cardiovascular, respiratory, and muscular systems, is significantly related to health among youth. Objective The aim of this systematic review was to identify health-related criterion-referenced cut-points for CRF among youth aged 5-17 years. Methods A systematic search of two electronic databases (MEDLINE and SPORTDiscus) was conducted in September 2020. Only peer-reviewed studies that developed health-related criterion-referenced cut-points for CRF among youth were eligible provided they included (1) youth aged 5-17 years from the general population; (2) at least one quantitative assessment of CRF (e.g., peak oxygen uptake [VO2peak]); ( 3) at least one quantitative assessment of health (e.g., cardiometabolic risk); (4) a criterion for health; and (5) a quantitative analysis (e.g., receiver operating characteristic [ROC] curve) of at least one health-related cut-point for CRF. A narrative synthesis was used to describe the results of the included studies. Results Collectively, 29 included studies developed health-related criterion-referenced cut-points for CRF among 193,311 youth from 23 countries. CRF cut-points, expressed as VO2peak, estimated using the 20-m shuttle run test, demonstrated high discriminatory ability (median area under the curve [AUC] = 0.71) for both cardiometabolic and obesity risk. Cut-points derived from maximal cycle-ergometer tests demonstrated moderate discriminatory ability (median AUC 0.64- 0.70) for cardiometabolic risk, and low discriminatory ability for early subclinical atherosclerosis (median AUC 0.56-0.63). Cut-points for CRF using submaximal treadmill exercise testing demonstrated high discriminatory ability for cardiometabolic risk, but only moderate discriminatory ability for obesity risk. CRF cut-points estimated using submaximal step testing demonstrated high discriminatory ability for cardiometabolic risk and moderate discriminatory ability for high blood pressure, while those for the 9-min walk/run test demonstrated moderate-to-high discriminatory ability for obesity risk. Collectively, CRF cutpoints, expressed as VO2peak, demonstrated moderate-to-high discriminatory ability (median AUC = 0.64) for cardiometabolic risk, obesity risk, and high blood pressure. Conclusions Currently, there is too wide a range of health-related criterion-referenced cut-points for CRF among youth to suggest universal age- and sex-specific thresholds. To further inform the development of universal cut-points, there is a need for additional research, using standardized testing protocols and health-risk definitions, that examines health-related criterion-referenced cut-points for CRF that are age, sex, and culturally diverse. Clinical Trials Registration PROSPERO registration number: CRD42020207458.
C1 [Rollo, Scott; Seguin, Nick; Sampson, Margaret; Lang, Justin J.; Tremblay, Mark S.] Childrens Hosp Eastern Ontario Res Inst, Hlth Act Living & Obes Res Grp, 401 Smyth Rd, Ottawa, ON K1H 8L1, Canada.
   [Rollo, Scott; Tremblay, Mark S.] Univ Ottawa, Fac Med, Sch Epidemiol & Publ Hlth, Ottawa, ON, Canada.
   [Fraser, Brooklyn J.] Univ Tasmania, Menzies Inst Med Res, Hobart, Tas, Australia.
   [Seguin, Nick; Tremblay, Mark S.] Carleton Univ, Dept Hlth Sci, Ottawa, ON, Canada.
   [Lang, Justin J.] Publ Hlth Agcy Canada, Ctr Surveillance & Appl Res, Ottawa, ON, Canada.
   [Tomkinson, Grant R.] Univ North Dakota, Dept Educ Hlth & Behav Studies, Grand Forks, ND 58201 USA.
   [Tomkinson, Grant R.] Univ South Australia, Alliance Res Exercise Nutr & Act ARENA, Sch Hlth Sci, Adelaide, SA, Australia.
   [Tremblay, Mark S.] Univ Ottawa, Dept Pediat, Fac Med, Ottawa, ON, Canada.
C3 University of Ottawa; Children's Hospital of Eastern Ontario; University
   of Ottawa; University of Tasmania; Menzies Institute for Medical
   Research; Carleton University; Public Health Agency of Canada;
   University of North Dakota Grand Forks; University of South Australia;
   University of Ottawa
RP Rollo, S (corresponding author), Childrens Hosp Eastern Ontario Res Inst, Hlth Act Living & Obes Res Grp, 401 Smyth Rd, Ottawa, ON K1H 8L1, Canada.; Rollo, S (corresponding author), Univ Ottawa, Fac Med, Sch Epidemiol & Publ Hlth, Ottawa, ON, Canada.
EM arollo@cheo.on.ca
RI Tomkinson, Grant/ABB-4991-2021; Sampson, Margaret/A-9128-2011; Fraser,
   Brooklyn/AAF-5132-2019; Tremblay, Mark/ABI-5477-2020; Lang,
   Justin/K-6202-2019
OI Fraser, Brooklyn/0000-0002-1752-5431; Lang, Justin/0000-0002-1768-319X;
   Tomkinson, Grant/0000-0001-7601-9670
FU Public Health Agency of Canada [4500414210]
FX This systematic review was funded by the Public Health Agency of Canada
   (#4500414210).
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NR 58
TC 11
Z9 12
U1 0
U2 16
PU ADIS INT LTD
PI NORTHCOTE
PA 5 THE WAREHOUSE WAY, NORTHCOTE 0627, AUCKLAND, NEW ZEALAND
SN 0112-1642
EI 1179-2035
J9 SPORTS MED
JI Sports Med.
PD JAN
PY 2022
VL 52
IS 1
BP 101
EP 122
DI 10.1007/s40279-021-01537-3
EA SEP 2021
PG 22
WC Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Sport Sciences
GA YH1FL
UT WOS:000691958900003
PM 34468952
DA 2025-06-11
ER

PT S
AU Tsiotra, PC
   Tsigos, C
AF Tsiotra, Panayoula C.
   Tsigos, Constantine
BE Chrousos, GP
   Tsigos, C
TI Stress, the endoplasmic reticulum, and insulin resistance
SO STRESS, OBESITY, AND METABOLIC SYNDROME
SE Annals of the New York Academy of Sciences
LA English
DT Article; Proceedings Paper
CT Bjorntorp Symposium on Stress, Obesity, and Metabolic Syndrome
CY APR 09-10, 2005
CL Athens, GREECE
SP Roche Hellas, Abbott Hellas, Pfizer Hellas, Sanofi Aventis Hellas, GlaxoSmithKline Hellas
DE endoplasmic reticulum; stress; obesity; insulin resistance; diabetes
ID UNFOLDED PROTEIN RESPONSE; PITUITARY-ADRENAL AXIS; PANCREATIC
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   METABOLIC SYNDROME-X; TNF-ALPHA; ER STRESS; TRANSLATIONAL CONTROL
AB Stress, such as nutrient deprivation, viral infections, inflammation, heat shock, or lipid accumulation, imposes a serious threat to the body. These stimuli, acting both on the central control stations of the stress system and its final effectors, catecholamines and glucocorticoids, and on the peripheral target tissues, can modulate insulin action in the body. Metabolic complications, such as diabetes, visceral obesity, and atherosclerosis have emerged as major health threats in the modern societies. Indeed, obesity and atherosclerosis are regarded as states of chronic low-grade inflammation, while inflammatory mediators and lipid accumulation can evoke a chronic stress at the cellular level, principally affecting the endoplasmic reticulum (ER). It has recently been shown that ER responds to metabolic stressors through a well coordinated molecular response that involves the transcriptional activation of multiple genes, the attenuation of protein synthesis and degradation of the ER-localized misfolded proteins, and the onset of apoptosis. This article examines the emerging role of stress on ER and its possible link with obesity, insulin resistance, and type 2 diabetes.
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C3 Athens Medical School; National & Kapodistrian University of Athens
RP Tsigos, C (corresponding author), 82 Vas,Sophias Ave, GR-11528 Athens, Greece.
EM ctsigos@hndc.gr
RI Tsiotra, Panayoula/AAE-6086-2019
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NR 103
TC 43
Z9 51
U1 0
U2 7
PU BLACKWELL SCIENCE PUBL
PI OXFORD
PA OSNEY MEAD, OXFORD OX2 0EL, ENGLAND
SN 0077-8923
BN 978-1-57331-625-5
J9 ANN NY ACAD SCI
JI Ann.NY Acad.Sci.
PY 2006
VL 1083
BP 63
EP 76
DI 10.1196/annals.1367.007
PG 14
WC Endocrinology & Metabolism; Multidisciplinary Sciences
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Science & Technology - Other Topics
GA BFR90
UT WOS:000244102900007
PM 17148734
DA 2025-06-11
ER

PT J
AU Darroudi, S
   Fereydouni, N
   Tayefi, M
   Ahmadnezhad, M
   Zamani, P
   Tayefi, B
   Kharazmi, J
   Tavalaie, S
   Heidari-Bakavoli, A
   Azarpajouh, MR
   Ferns, GA
   Mohammadpour, AH
   Esmaily, H
   Ghayour-Mobarhan, M
AF Darroudi, Susan
   Fereydouni, Narges
   Tayefi, Maryam
   Ahmadnezhad, Mahsa
   Zamani, Parvin
   Tayefi, Batool
   Kharazmi, Jasmin
   Tavalaie, Shima
   Heidari-Bakavoli, Alireza
   Azarpajouh, Mahmoud R.
   Ferns, Gordon A.
   Mohammadpour, Amir H.
   Esmaily, Habibollah
   Ghayour-Mobarhan, Majid
TI Oxidative stress and inflammation, two features associated with a high
   percentage body fat, and that may lead to diabetes mellitus and
   metabolic syndrome
SO BIOFACTORS
LA English
DT Article
DE oxidative stress; metabolic syndrome; SOD1
ID C-REACTIVE PROTEIN; INSULIN-RESISTANCE; RISK; OBESITY; OVERWEIGHT;
   DISEASE
AB Obesity is an important feature of the metabolic syndrome and is associated with an increased risk of type 2 diabetes mellitus, cardiovascular disease, and some cancers. The aim of this study was to determine the relationship between body fat percentage and an imbalance of the prooxidant/antioxidant balance (PAB), serum superoxide dismutase (SOD1) and inflammation (serum hs-CRP) and increase risk of metabolic syndrome and diabetes mellitus. In this study, 9154 individuals were recruited as part of the Mashhad Stroke and Heart Association Disorder (MASHAD) study. Subjects were categorized into two groups according to body fat percentage as defined >25% in male and > 30% in female, according to gender. Biochemical factors, including serum PAB, SOD1, and hs-CRP were measured in all subjects. SPSS version 18 was used for statistical analyses for all. GraphPad Prism 6 for figures was used. Of total number of subjects (9154), 6748 (73.7%) were found to have a high body fat (BF) percentage. Serum hs-CRP and PAB were significantly higher in individuals with a high BF percentage (P < 0.05) but SOD1 was not significantly different between the two groups (P > 0.05). BF percentage, serum PAB and serum hs-CRP were significantly higher in individuals with metabolic syndrome and diabetes versus those without metabolic syndrome and diabetes mellitus (P < 0.05), however serum SOD1 was significantly lower in individuals with metabolic syndrome (P < 0.005). Oxidative stress and inflammation are two factors that may link the presence of high BF percentage with the development of metabolic syndrome, diabetes, and cardiovascular disease. (c) 2018 BioFactors, 45(1):35-42, 2019
C1 [Darroudi, Susan; Fereydouni, Narges] Mashhad Univ Med Sci, Sch Med, Dept Modern Sci & Technol, Mashhad, Iran.
   [Tayefi, Maryam] MUMS, Imam Reza Hosp, Dept Cardiovasc, Mashhad, Iran.
   [Tayefi, Maryam] Mashhad Univ Med Sci, Univ Int Accreditat, Clin Res Unit, Int Off, Mashhad, Iran.
   [Ahmadnezhad, Mahsa] Tabriz Univ Med Sci, Dept Community Nutr, Nutr Res Ctr, Tabriz, Iran.
   [Zamani, Parvin] Mashhad Univ Med Sci, Fac Med, Dept Med Biotechnol, Mashhad, Iran.
   [Tayefi, Batool] Iran Univ Med Sci, Prevent Med & Publ Hlth Res Ctr, Tehran, Iran.
   [Kharazmi, Jasmin] Islamic Azad Univ, Mashhad Branch, Dept Biol, Mashhad, Iran.
   [Tavalaie, Shima; Ghayour-Mobarhan, Majid] Mashhad Univ Med Sci, Sch Med, Metab Syndrome Res Ctr, Mashhad, Iran.
   [Heidari-Bakavoli, Alireza] Mashhad Univ Med Sci, Sch Med, Cardiovasc Res Ctr, Mashhad, Iran.
   [Azarpajouh, Mahmoud R.] Brighton & Sussex Med Sch, Div Med Educ, Brighton BN1 9PH, Sussex, England.
   [Ferns, Gordon A.; Mohammadpour, Amir H.] Mashhad Univ Med Sci, Pharmaceut Inst Technol, Pharmaceut Res Ctr, Mashhad, Iran.
   [Mohammadpour, Amir H.] Mashhad Univ Med Sci, Sch Pharm, Dept Clin Pharm, Mashhad, Iran.
   [Esmaily, Habibollah] Mashhad Univ Med Sci, Social Determinants Hlth Res, Mashhad, Iran.
C3 Mashhad University of Medical Sciences; Mashhad University of Medical
   Sciences; Mashhad University of Medical Sciences; Tabriz University of
   Medical Science; Mashhad University of Medical Sciences; Iran University
   of Medical Sciences; Islamic Azad University; Mashhad University of
   Medical Sciences; Mashhad University of Medical Sciences; University of
   Brighton; University of Sussex; Mashhad University of Medical Sciences;
   Mashhad University of Medical Sciences; Mashhad University of Medical
   Sciences
RP Ghayour-Mobarhan, M (corresponding author), Mashhad Univ Med Sci, Sch Med, Biochem Nutr Res Ctr, Mashhad 9919991766, Iran.; Mohammadpour, AH (corresponding author), Mashhad Univ Med Sci, Pharmaceut Res Ctr, POB 91775-1365, Mashhad, Iran.
EM mohamadpoorah@mums.ac.ir; ghayourm@mums.ac.ir
RI Fereydouni, Narges/ABD-8931-2020; Tayefi Nasrabadi, Batool/U-7014-2019;
   Ghayour-Mobarhan, Majid/AAY-5963-2020; zamani, parvin/I-3759-2016
OI tayefi, maryam/0000-0003-4637-7754; Tayefi Nasrabadi,
   Batool/0000-0002-0913-7324
FU Mashhad University of Medical Science
FX We thank Prof. Gordon A. Ferns and Prof. Gholam Hossein Haghnia for
   their critical review of this manuscript. This study was support by
   grant from Mashhad University of Medical Science.
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NR 39
TC 33
Z9 34
U1 0
U2 9
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0951-6433
EI 1872-8081
J9 BIOFACTORS
JI Biofactors
PD JAN-FEB
PY 2019
VL 45
IS 1
BP 35
EP 42
DI 10.1002/biof.1459
PG 8
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA HK3PX
UT WOS:000457830400003
PM 30561055
DA 2025-06-11
ER

PT J
AU Kisely, S
   Siskind, D
   Scott, JG
   Najman, JM
AF Kisely, Stephen
   Siskind, Dan
   Scott, James G.
   Najman, Jake M.
TI Self-reported child maltreatment and cardiometabolic risk in 30-year-old
   adults
SO INTERNAL MEDICINE JOURNAL
LA English
DT Article
DE cardiometabolic risk; obesity; child maltreatment; physical abuse;
   emotional abuse; neglect
ID POSTTRAUMATIC-STRESS-DISORDER; ALL-CAUSE MORTALITY; C-REACTIVE PROTEIN;
   BODY-MASS INDEX; TRAUMA QUESTIONNAIRE; FOLLOW-UP; INTERGENERATIONAL
   TRANSMISSION; RETROSPECTIVE REPORTS; MATER-UNIVERSITY; PHYSICAL HEALTH
AB Background Childhood maltreatment (CM) is associated with both dietary fat intake and obesity in later life. There is less information on associations with metabolic risk factors and specific types of CM such as physical, sexual and emotional abuse, as well as neglect. Aims To assess the association between five types of self-reported CM and a range of obesity and metabolic indicators in a subsample of a birth cohort. Methods This was a study of 1689 adults born in a major metropolitan maternity hospital in Australia and followed up 30 years later. Body mass index, bioimpedance and fasting lipid levels/insulin resistance were measured. Details on self-reported CM were collected using the Child Trauma Questionnaire. We adjusted for birth weight, parental income and relationship at participants' birth, as well as maternal age and alcohol or tobacco use. We also adjusted for participants' smoking, depression, educational level, marital and employment status at follow up. Results One-fifth reported maltreatment (n = 362), most commonly emotional neglect (n = 175), followed by emotional abuse (n = 128), physical neglect (n = 123), sexual (n = 121) and physical abuse (n = 116). On adjusted analyses, there were significant associations for CM, particularly neglect or emotional abuse, and one or more of the following outcomes: obesity, the total cholesterol/high-density lipoprotein cholesterol (TC/HDL-C) ratio and HDL levels. Results for other outcomes were more equivocal. Conclusions Of child maltreatment types, emotional abuse and neglect show the strongest associations with obesity and several cardiometabolic risk factors, therefore highlighting the public health importance of early intervention to reduce childhood adversity.
C1 [Kisely, Stephen; Siskind, Dan] Metro South Addict & Mental Hlth Serv, Brisbane, Qld, Australia.
   [Kisely, Stephen; Siskind, Dan] Univ Queensland, Sch Clin Med, Brisbane, Qld, Australia.
   [Scott, James G.] QIMR Berghofer Med Res Inst, Mental Hlth Program, Brisbane, Qld, Australia.
   [Scott, James G.] Metro North Mental Hlth Serv, Brisbane, Qld, Australia.
   [Scott, James G.; Najman, Jake M.] Univ Queensland, Sch Publ Hlth, Publ Hlth Bldg, Brisbane, Qld, Australia.
   [Kisely, Stephen] Dalhousie Univ, Dept Psychiat, Halifax, NS, Canada.
   [Kisely, Stephen] Dalhousie Univ, Dept Community Hlth, Halifax, NS, Canada.
   [Kisely, Stephen] Dalhousie Univ, Dept Epidemiol, Halifax, NS, Canada.
C3 University of Queensland; QIMR Berghofer Medical Research Institute;
   University of Queensland; Dalhousie University; Dalhousie University;
   Dalhousie University
RP Kisely, S (corresponding author), Univ Queensland, Sch Med, Princess Alexandra Hosp, Level 4,Bldg 1,Ipswich Rd, Woolloongabba, Qld 4102, Australia.
EM s.kisely@uq.edu.au
RI Najman, Jackob/B-1527-2008; Kisely, Steve/B-4680-2012; Scott,
   James/D-5900-2012; Siskind, Dan/A-9812-2014
OI Kisely, Steve/0000-0003-4021-2924; Scott, James/0000-0002-0744-0688;
   Siskind, Dan/0000-0002-2072-9216
FU National Health and Medical Research Council (NHMRC) Emerging Leadership
   Fellowship [GNT1194635]
FX D. Siskind is supported in part by a National Health and Medical
   Research Council (NHMRC) Emerging Leadership Fellowship (GNT1194635).
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NR 72
TC 12
Z9 11
U1 0
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1444-0903
EI 1445-5994
J9 INTERN MED J
JI Intern. Med. J.
PD JUL
PY 2023
VL 53
IS 7
BP 1121
EP 1130
DI 10.1111/imj.15824
EA JUL 2022
PG 10
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA M9VA5
UT WOS:000823063900001
PM 35607779
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Bathina, N
   Ganni, S
   Kolalapudi, SA
   Konala, S
   Dharavath, K
   Reddy, MTK
AF Bathina, Navya
   Ganni, Sadhika
   Kolalapudi, Seetharam A.
   Konala, Subhashini
   Dharavath, Kalyan
   Reddy, Mandem T. K.
TI Prevalence of Metabolic Syndrome in Vitiligo Patients and its Relation
   to Vitiligo Severity - A Cross-Sectional Study
SO INDIAN DERMATOLOGY ONLINE JOURNAL
LA English
DT Article
DE Melanin; metabolic syndrome; oxidative stress; vitiligo
AB Background: In vitiligo, there is a significant decrease in melanocytes and melanin. The decrease in melanin causes oxidative stress, with a chance of causing metabolic syndrome. Hence, there is a need to look for metabolic syndrome in vitiligo. Aim and Objectives: To estimate the prevalence of metabolic syndrome in vitiligo patients and to evaluate the relationship between the severity and progression of vitiligo and metabolic syndrome. Materials and Methods: A hospital-based cross-sectional study was conducted on 178 vitiligo cases and 178 controls who were age- and sex-matched. The type of vitiligo, stability by vitiligo disease activity score (VIDA), and severity by vitiligo area severity index (VASI) were noted. The waist circumference, blood pressure, fasting lipid profile, and fasting blood sugar were measured for cases and controls. Metabolic syndrome was diagnosed based on Harmonization Asian criteria. Results: The mean age in cases was 34.38 years, and in controls, it was 35.67 years. The majority were females in both cases (52.2%) and controls (55.6%). Most have a VIDA score of 2+ (41.6%). The mean VASI score was 2.54. The percentage of metabolic syndrome was higher in cases (36%) compared to controls (24.2%) (P = 0.015). The mean age was lower in vitiligo cases with metabolic syndrome (38.83 years) compared to controls with metabolic syndrome (43.14 years). Metabolic syndrome was more frequent in the vitiligo vulgaris type (48.9%) than in acral and segmental vitiligo. Metabolic syndrome was more common in patients with high VIDA (45%) and VASI (52.3%) scores compared to patients with low VIDA (25%) and VASI (27.3%) scores. Limitation: It is a hospital-based study, so controls were not from the general population. Conclusion: The prevalence of metabolic syndrome was higher in vitiligo patients compared to controls, and it was higher in patients with active and severe disease. Screening and close monitoring of vitiligo patients help in the early diagnosis of metabolic syndrome and reduce the risk of cardiovascular disease.
C1 [Bathina, Navya; Ganni, Sadhika; Kolalapudi, Seetharam A.; Konala, Subhashini; Dharavath, Kalyan; Reddy, Mandem T. K.] GSL Med Coll & Gen Hosp, Dept Dermatol Venereol & Leprosy, Rajahmahendravaram 533296, Andhra Pradesh, India.
RP Konala, S (corresponding author), GSL Med Coll & Gen Hosp, Dept Dermatol Venereol & Leprosy, Rajahmahendravaram 533296, Andhra Pradesh, India.
EM subha.konala@gmail.com
CR Atas H, 2017, BALK MED J, V34, P219, DOI 10.4274/balkanmedj.2016.1005
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NR 13
TC 3
Z9 3
U1 0
U2 1
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, Maharashtra, INDIA
SN 2229-5178
EI 2249-5673
J9 INDIAN DERMATOL ONL
JI Indian Dermatol. Online J.
PD JUL-AUG
PY 2024
VL 15
IS 4
BP 612
EP 615
DI 10.4103/idoj.idoj_966_23
PG 4
WC Dermatology
WE Emerging Sources Citation Index (ESCI)
SC Dermatology
GA G4J3K
UT WOS:001316316600006
PM 39050072
OA gold
DA 2025-06-11
ER

PT J
AU Bermudes, RA
   Keck, PE
   Welge, JA
AF Bermudes, Richard A.
   Keck, Paul E., Jr.
   Welge, Jeffrey A.
TI The prevalence of the metabolic syndrome in psychiatric inpatients with
   primary psychotic and mood disorders
SO PSYCHOSOMATICS
LA English
DT Article
ID 3RD NATIONAL-HEALTH; MORTALITY; BLOOD; RISK; DEPRESSION; PEOPLE; ADULTS
AB Patients with severe mental illness have elevated rates of cardiovascular disease (CVD) and diabetes compared with the general population, but little is known about the prevalence of the metabolic syndrome that predisposes patients with severe mental illness to both medical conditions. The purpose of this study was to assess the prevalence of the metabolic syndrome by surveying hospital records of psychiatric inpatients with severe mood and psychotic disorders. The study group was 102 consecutively admitted adult patients with a primary DSM-IV diagnosis of a mood or psychotic disorder. Criteria for comorbid metabolic syndrome required at least three of the five factors defined by the National Cholesterol Education Program. The prevalence of the metabolic syndrome was 38.6% in this cohort, and it was associated with increasing age, body mass index, and Caucasian ethnicity. The metabolic syndrome was common in this cohort of psychiatric inpatients, and the high rate of the metabolic syndrome likely represents an intermediate step in the future development of CVD and diabetes, which may provide a point of early intervention to prevent the occurrence of these two medical illnesses in chronically mentally ill patients.
C1 Univ Calif Davis, Med Ctr, Dept Psychiat & Behav Sci, Sacramento, CA 95817 USA.
   Univ Cincinnati, Coll Med, Dept Psychiat, Psychopharmacol Res Program, Cincinnati, OH 45221 USA.
   Cincinnati Vet Affairs Med Ctr, Gen Clin Res Ctr, Cincinnati, OH USA.
   Univ Connecticut, Coll Med, Dept Psychiat, Quantitiat Methods Program, Storrs, CT 06269 USA.
   Univ Cincinnati, Coll Med, Dept Environm Hlth, Dept Epidemiol & Biostat, Cincinnati, OH 45221 USA.
C3 University of California System; University of California Davis;
   University System of Ohio; University of Cincinnati; US Department of
   Veterans Affairs; Veterans Health Administration (VHA); Cincinnati VA
   Medical Center; University of Connecticut; University System of Ohio;
   University of Cincinnati
RP Bermudes, RA (corresponding author), Univ Calif Davis, Med Ctr, Dept Psychiat & Behav Sci, 2230 Stockton Blvd, Sacramento, CA 95817 USA.
EM rabermudes@ucdavis.edu
CR [Anonymous], 2004, J CLIN PSYCHIAT, V65, P267
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NR 33
TC 26
Z9 28
U1 0
U2 13
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0033-3182
EI 1545-7206
J9 PSYCHOSOMATICS
JI Psychosomatics
PD DEC
PY 2006
VL 47
IS 6
BP 491
EP 497
DI 10.1176/appi.psy.47.6.491
PG 7
WC Psychiatry; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry; Psychology
GA 107NE
UT WOS:000242177500006
PM 17116950
OA Bronze
DA 2025-06-11
ER

PT J
AU Delarue, J
   Matzinger, O
   Binnert, C
   Schneiter, P
   Chioléro, R
   Tappy, L
AF Delarue, J
   Matzinger, O
   Binnert, C
   Schneiter, P
   Chioléro, R
   Tappy, L
TI Fish oil prevents the adrenal activation elicited by mental stress in
   healthy men
SO DIABETES & METABOLISM
LA English
DT Article
DE cortisol; epinephrine; sympathetic nervous system; N-3 fatty acids;
   insulin resistance syndrome
ID CORTICOTROPIN-RELEASING FACTOR; VISCERAL ADIPOSE-TISSUE; FREE
   FATTY-ACIDS; SYMPATHETIC ACTIVATION; DOCOSAHEXAENOIC ACID;
   INSULIN-RESISTANCE; SKELETAL-MUSCLE; METABOLIC SYNDROME; NERVOUS-SYSTEM;
   BLOOD-FLOW
AB Objectives: A diet rich in n-3 fatty acids (fish oils) is associated with reduced risks of cardiovascular and metabolic diseases, but the mechanisms remain incompletely understood. Sympathoadrenal activation is postulated to be involved in the pathogenesis of these diseases, and may be inhibited by n-3 fatty acids. We therefore evaluated the effects of a diet supplemented with n-3 fatty acids on the stimulation of the sympathetic nervous system and of stress hormones elicited by a mental stress.
   Methods: Seven human volunteers were studied on two occasions, before and after 3 weeks of supplementation with 7.2 g/day fish oil. On each occasion, the concentrations of plasma cortisol, and catecholamines, energy expenditure (indirect calorimetry), and adipose tissue lipolysis (plasma non esterified fatty acid concentrations) were monitored in basal conditions followed by a 30 min mental stress (mental arithmetics and Stroop's test) and a 30 min recovery period.
   Results: In control conditions, mental stress significantly increased heart rate, mean blood pressure, and energy expenditure. It increased plasma epinephrine from 60.9 +/- 6.2 to 89.3 +/- 16.1 pg/ml (p < 0.05), plasma cortisol from 291 +/- 32 to 372 +/- 37 mumol/l (p < 0.05) and plasma non esterified fatty acids from 409 +/- 113 to 544 +/- 89 mumol/l (p < 0.05). After 3 weeks of a diet supplemented with n-3 fatty acids the stimulation by mental stress of plasma epinephrine, cortisol energy expenditure, and plasma non esterified fatty acids concentrations, were all significantly blunted.
   Conclusion: Supplementation with n-3 fatty acids inhibits the adrenal activation elicited by a mental stress, presumably through effects exerted at the level of the central nervous system.
C1 Univ Lausanne, Inst Physiol, CH-1005 Lausanne 41, Switzerland.
   Hop Cavale Blanche, Lab Reg Nutr Humaine, Brest, France.
   Univ Lausanne Hosp, Surg Intens Care Unit, Lausanne, Switzerland.
C3 University of Lausanne; CHU Brest; Universite de Bretagne Occidentale;
   University of Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV)
RP Tappy, L (corresponding author), Univ Lausanne, Inst Physiol, 7 Rue Bugnon, CH-1005 Lausanne 41, Switzerland.
RI Tappy, Luc/A-8911-2017
OI Tappy, Luc/0000-0001-8469-4692; Schneiter, Philippe/0000-0002-7167-2707;
   Matzinger, Oscar/0000-0002-5054-1564
CR Battilana P, 2001, J CLIN ENDOCR METAB, V86, P124, DOI 10.1210/jc.86.1.124
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NR 36
TC 117
Z9 125
U1 0
U2 14
PU MASSON EDITEUR
PI PARIS 06
PA 120 BLVD SAINT-GERMAIN, 75280 PARIS 06, FRANCE
SN 1262-3636
J9 DIABETES METAB
JI Diabetes Metab.
PD JUN
PY 2003
VL 29
IS 3
BP 289
EP 295
DI 10.1016/S1262-3636(07)70039-3
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 701DC
UT WOS:000184152100012
PM 12909818
DA 2025-06-11
ER

PT J
AU Amadou, C
   Heude, B
   de Lauzon-Guillain, B
   Lioret, S
   Descarpentrie, A
   Zins, M
   Charles, MA
AF Amadou, Coralie
   Heude, Barbara
   de Lauzon-Guillain, Blandine
   Lioret, Sandrine
   Descarpentrie, Alexandra
   Zins, Marie
   Charles, Marie -Aline
TI Early origins of metabolic and overall health in young adults: An
   outcome-wide analysis in a general cohort population
SO DIABETES & METABOLISM
LA English
DT Article
DE Birth weight; Developmental origins of health and diseases; Global
   health; Mental health; Metabolic syndrome
ID IMPAIRED GLUCOSE-TOLERANCE; SYSTOLIC BLOOD-PRESSURE; BIRTH-WEIGHT;
   SUBSEQUENT RISK; CAUSAL INFERENCE; SEX DIFFERENCE; FETAL ORIGINS;
   ASSOCIATION; GROWTH; CHILDREN
AB Introduction: Long-term consequences of impaired fetal growth are well documented for cardiometabolic outcomes. We propose an outcome-wide analysis of the association between birth weight (BW) and long-term health in a large contemporary adult cohort.Methods: The study included 73,315 participants under 60 years with a reliable BW from the French nation-wide Constances cohort. Low and high BW (LBW/HBW) were defined as BW<10th and >90th of sex-specific percentiles. Associations between BW and outcomes were analyzed with a sex-stratified modified Poisson regression adjusted for the participant's age, maternal health history, geographical origins, and parents' occupation.Results: Mean BW (10th-90th percentile) was 3390 g (2800-4000) for men and 3247g (2680-3820) for women. In men, LBW was associated with (RR [CI95]): fasting glucose impairment (1.33 [1.16;1.52]); hyper-triglyceridemia (1.27 [1.17;1.37]); high blood pressure (HBP) (1.15 [1.07;1.24]); non-alcoholic fatty liver dis-ease NAFLD (1.13 [1.02;1.24]); high LDL-cholesterol (1.12 [1.05;1.21]); anxiety (1.12 [1.01;1.24]) and depression (1.09 [1.00;1.18]). HBW was associated with obesity (1.21 [1.08;1.35]). In women, LBW was asso-ciated with fasting glucose impairment (1.31 [1.12;1.54]); HBP (1.27 [1.16;1.4]); hypertriglyceridemia (1.20 [1.05;1.36]); anxiety (1.10 [1.03;1.17]); and asthma (1.09 [1;1.19}). HBW was associated with obesity (1.24 [1.13;1.36]) and NAFLD (1.20 [1.06;1.37). LBW and HBW were associated with a lesser likelihood of tertiary education attainment in both sexes. Participants' education level was a significant partial mediator of the association between LBW and outcomes. Conclusion: Extreme BW is associated with long-term health. It should be considered in the personalized pre-vention of cardiometabolic, respiratory, and mental health conditions in adulthood, especially in socio-eco-nomically disadvantaged populations.(c) 2022 Elsevier Masson SAS. All rights reserved.
C1 [Amadou, Coralie] Paris Saclay Univ, Sud Francilien Hosp, Dept Diabet & endocrinol, Paris, France.
   [Heude, Barbara; de Lauzon-Guillain, Blandine; Lioret, Sandrine; Descarpentrie, Alexandra; Charles, Marie -Aline] Univ Paris Cite, Ctr Res Epidemiol & Stat CRESS, INSERM, INRAE, Paris, France.
   [Zins, Marie] Paris Saclay Univ, Univ Paris Cite, Populat Based Cohorts Unit, INSERM,Univ Versailles St Quentin En Yvelines,UMS, Paris, France.
C3 Centre Hospitalier Sud Francilien; Universite Paris Saclay; INRAE;
   Universite Paris Cite; Institut National de la Sante et de la Recherche
   Medicale (Inserm); Institut National de la Sante et de la Recherche
   Medicale (Inserm); Universite Paris Cite; Universite Paris Saclay
RP Amadou, C (corresponding author), Paris Saclay Univ, Sud Francilien Hosp, Dept Diabet & endocrinol, Paris, France.
EM coralie.amadou@u-psud.fr
RI Charles, Marie/F-8567-2017; Amadou, Coralie/GPX-1960-2022; Heude,
   Barbara/G-3095-2016; LIORET, Sandrine/G-5568-2017; Zins,
   Marie/AAX-6551-2021; de Lauzon-Guillain, Blandine/P-4659-2016
OI Descarpentrie, Alexandra/0000-0002-2666-5380; Lioret,
   Sandrine/0000-0002-2483-7820; de Lauzon-Guillain,
   Blandine/0000-0001-5887-8842
FU ANR [ANR-11-INBS-0002]; Caisse nationale d'assurance maladie (CNAM);
   ANR; French Ministry of Research; Merck Sharp Dohme (MSD); AstraZeneca;
   Lundbeck; L'Oreal
FX The Constances Cohort Study is supported and funded by the Caisse
   nationale d'assurance maladie (CNAM). The Constances Cohort Study is an
   "Infrastructure Nationale en Biologie et Sante" and benefits from a
   grant from ANR (ANR-11-INBS-0002) and the French Ministry of Research.
   Constances is also partly funded by Merck Sharp & Dohme (MSD),
   AstraZeneca, Lundbeck and L'Oreal. None of these funding sources had any
   role in the study design, collection, and analysis of data or decision
   to publish.
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NR 36
TC 4
Z9 5
U1 0
U2 5
PU MASSON EDITEUR
PI MOULINEAUX CEDEX 9
PA 21 STREET CAMILLE DESMOULINS, ISSY, 92789 MOULINEAUX CEDEX 9, FRANCE
SN 1262-3636
EI 1878-1780
J9 DIABETES METAB
JI Diabetes Metab.
PD MAR
PY 2023
VL 49
IS 2
AR 101414
DI 10.1016/j.diabet.2022.101414
EA DEC 2022
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 7U3AG
UT WOS:000912006200001
PM 36493959
DA 2025-06-11
ER

PT J
AU Zheng, GH
   Li, MY
   Lan, XL
   Yan, XH
   Lin, Q
   Chen, LD
   Tao, J
   Zheng, X
   Li, JZ
   Chen, B
   Fang, QY
AF Zheng, Guohua
   Li, Moyi
   Lan, Xiulu
   Yan, Xinghui
   Lin, Qiu
   Chen, Lidian
   Tao, Jing
   Zheng, Xin
   Li, Junzhe
   Chen, Bai
   Fang, Qianying
TI The effect of Baduanjin exercise for physical and psychological
   wellbeing of college students: study protocol for a randomized
   controlled trial
SO TRIALS
LA English
DT Article
DE Baduanjin exercise; College students; Physical health; Mental health;
   Randomized controlled trial
ID SLEEP QUALITY INDEX; UNIVERSITY-STUDENTS; METABOLIC SYNDROME;
   BODY-COMPOSITION; SELF-EFFICACY; MENTAL-HEALTH; OF-LIFE; PREVALENCE;
   ADOLESCENT; FITNESS
AB Background: The physical and mental health of college students tends to continuously decline around the world. Since they are in a significant transition period which presents opportunities and challenges in health promotion, it is important to improve their health in this period. As a traditional Chinese exercise form which combines movements with breath and mind, Baduanjin may be one of the selectable effective exercises. However, evidence of Baduanjin exercise for college students has not been completely established. The primary aim of this trial is to evaluate the effectiveness and safety of Baduanjin exercise for physical and mental health of college students through a rigorous randomization, parallel-controlled design.
   Method/design: We will conduct a randomized, single-blind, parallel-controlled trial. A total of 222 college students from Fujian University of Traditional Chinese Medicine who meet the eligibility criteria will be recruited and randomly allocated into Baduanjin training or usual exercise control group. Baduanjin training will last 12 weeks (1 h per day, 5 days per week). The physical and psychological outcomes, including lumbar muscle strength, lumbar proprioception function, physical fitness, as well as self-reported symptom intensity, stress, self-esteem, mood, quality of life, quality of sleep, and adverse events, will be evaluated by blinded outcome assessors at baseline, 13 weeks (at the end of intervention), and 25 weeks (after the 12-week follow-up period).
   Discussion: This protocol presents an objective design of a randomized, single-blind trial that aims to evaluate the effectiveness and safety of Baduanjin exercise for physical and mental health of college students. If the outcome is positive, the results will provide higher-quality evidence to better inform the college students regarding their selection about whether to receive such exercise.
C1 [Zheng, Guohua] Fujian Univ Tradit Chinese Med, Acad Integrat Med, Fuzhou 350122, Peoples R China.
   [Li, Moyi; Lan, Xiulu; Tao, Jing; Zheng, Xin; Li, Junzhe; Chen, Bai; Fang, Qianying] Fujian Univ Tradit Chinese Med, Rehabil Med Coll, Fuzhou 350122, Peoples R China.
   [Yan, Xinghui; Lin, Qiu] Fujian Univ Tradit Chinese Med, Dept Phys Educ, Fuzhou 350122, Peoples R China.
   [Chen, Lidian] Fujian Univ Tradit Chinese Med, Fuzhou 350122, Peoples R China.
C3 Fujian University of Traditional Chinese Medicine; Fujian University of
   Traditional Chinese Medicine; Fujian University of Traditional Chinese
   Medicine; Fujian University of Traditional Chinese Medicine
RP Chen, LD (corresponding author), Fujian Univ Tradit Chinese Med, Fuzhou 350122, Peoples R China.
EM lidianchen87@163.com
RI Zheng, Guo/E-8256-2013; Tao, Jing/GVS-6340-2022; Chen,
   Lidian/GSN-6461-2022
OI Chen, Lidian/0000-0002-8699-0839; Chen, Lidian/0000-0002-6454-7932; Tao,
   Jing/0000-0002-4895-2065; Tao, Jing/0000-0001-9751-5294
FU Special Scientific Research Fund of Public Welfare Profession of China,
   Ministry of Science and Technology [201307004]; Ministry of Finance of
   the People's Republic of China; Rehabilitation Research Center of Fujian
   province; Rehabilitation Research Center for Traditional Chinese
   Medicine, State Administration of Traditional Chinese Medicine of the
   People's Republic of China
FX This study is funded by the Special Scientific Research Fund of Public
   Welfare Profession of China (Grant No. 201307004), Ministry of Science
   and Technology and Ministry of Finance of the People's Republic of
   China. It is supported by Rehabilitation Research Center of Fujian
   province and Rehabilitation Research Center for Traditional Chinese
   Medicine, State Administration of Traditional Chinese Medicine of the
   People's Republic of China.
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NR 63
TC 25
Z9 28
U1 18
U2 116
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1745-6215
J9 TRIALS
JI Trials
PD DEC 5
PY 2013
VL 14
AR 422
DI 10.1186/1745-6215-14-422
PG 9
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Research & Experimental Medicine
GA 276OG
UT WOS:000328759000008
PM 24308310
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Bojanic, I
   Bjerkeset, O
   Williams, LJ
   Berk, M
   Sund, ER
   Sletvold, H
AF Bojanic, Ivana
   Bjerkeset, Ottar
   Williams, Lana J.
   Berk, Michael
   Sund, Erik R.
   Sletvold, Hege
TI Associations of Cardiovascular Agents and Metformin with Depression
   Symptoms: A Cross-Sectional Analysis from the HUNT Study, Norway
SO DRUGS-REAL WORLD OUTCOMES
LA English
DT Article
ID QUALITY-OF-LIFE; HOSPITAL ANXIETY; SCIENTIFIC STATEMENT; ANGIOTENSIN
   SYSTEM; METABOLIC SYNDROME; DIABETES-MELLITUS; HEART-DISEASE; HEALTH;
   RISK; POPULATION
AB Background Cardiovascular agents, including angiotensin-converting enzyme inhibitors, angiotensin II receptor inhibitors, acetylsalicylic acid, statins, and metformin, have demonstrated benefits for depression. However, there is scant evaluation of these drugs' antidepressant properties in large population settings. Objective This study aimed to examine cross-sectional associations between depression symptoms and the use of cardiovascular agents and metformin in populations with cardiovascular diseases or diabetes mellitus. Methods Participants in the Trondelag Health Study 2006-08 (HUNT3, n = 40,516) and 2017-19 (HUNT4, n = 42,103) were included and data on their drug use from 2006 to 2019 was retrieved from the Norwegian Prescription Database. The outcome was self-reported depression symptoms defined by the Hospital Anxiety and Depression Scale. Associations between cardiovascular agents or metformin use and self-reported depression were analyzed by multi-level logistic regression in sex-stratified samples. Results Among men with cardiovascular diseases, use of acetylsalicylic acid was associated with reduced depression symptoms compared with acetylsalicylic acid non-users (reference) in HUNT3 and HUNT4 [risk ratio = 0.76; 95% confidence interval 0.59-0.94, risk ratio = 0.67; 95% CI 0.52-0.82, respectively]. Similarly, male statin users had a lower likelihood of reporting depression than statin non-users in HUNT3 (risk ratio = 0.70; 95% confidence interval 0.54-0.86) and HUNT4 (risk ratio = 0.67; 95% confidence interval 0.51-0.84). Associations between statins or acetylsalicylic acid use and reduced depression symptoms were detected in women with cardiovascular diseases in HUNT4. We found no statistical support for associations between other cardiovascular agents or metformin use and a reduced or increased depression symptom risk. Conclusions Results suggest negative associations between acetylsalicylic acid or statin use and depression symptoms. However, longitudinal cohort studies and randomized controlled trials are required to confirm the antidepressant effects of these drugs.
C1 [Bojanic, Ivana; Bjerkeset, Ottar; Sund, Erik R.; Sletvold, Hege] Nord Univ, Fac Nursing & Hlth Sci, PB 93, N-7601 Levanger, Norway.
   [Bojanic, Ivana] Norwegian Univ Sci & Technol, NTNU, Fac Med & Hlth Sci, Dept Publ Hlth & Nursing, Trondheim, Norway.
   [Bjerkeset, Ottar] Norwegian Univ Sci & Technol, NTNU, Fac Med & Hlth Sci, Dept Mental Hlth, Trondheim, Norway.
   [Williams, Lana J.; Berk, Michael] Deakin Univ, Barwon Hlth, Sch Med, Inst Mental & Phys Hlth & Clin Translat,IMPACT, Geelong, Vic, Australia.
   [Sund, Erik R.] Norwegian Univ Sci & Technol, Fac Med & Hlth Sci, Dept Publ Hlth & Nursing, HUNT Res Ctr,NTNU, Levanger, Norway.
   [Sund, Erik R.] Nord Trondelag Hosp Trust, Levanger Hosp, Levanger, Norway.
C3 Nord University; Norwegian University of Science & Technology (NTNU);
   Norwegian University of Science & Technology (NTNU); Deakin University;
   Barwon Health; Norwegian University of Science & Technology (NTNU)
RP Bojanic, I (corresponding author), Nord Univ, Fac Nursing & Hlth Sci, PB 93, N-7601 Levanger, Norway.; Bojanic, I (corresponding author), Norwegian Univ Sci & Technol, NTNU, Fac Med & Hlth Sci, Dept Publ Hlth & Nursing, Trondheim, Norway.
EM ivana.bojanic@nord.no
RI Sletvold, Hege/GKG-4906-2022; Berk, Michael/AGH-9427-2022; Bojanic,
   Ivana/IVU-7447-2023; Berk, Michael/M-7891-2013
OI Bojanic, Ivana/0000-0003-2609-7536; Berk, Michael/0000-0002-5554-6946
FU Faculty of Nursing and Health Sciences at Nord University, Nord
FX This work was supported by the Faculty of Nursing and Health Sciences at
   Nord University, Nord.
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NR 67
TC 5
Z9 5
U1 0
U2 1
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 2199-1154
EI 2198-9788
J9 DRUGS-REAL WOR OUTC
JI Drugs-Real World Outcomes
PD SEP
PY 2022
VL 9
IS 3
BP 503
EP 516
DI 10.1007/s40801-022-00321-7
EA JUL 2022
PG 14
WC Pharmacology & Pharmacy
WE Emerging Sources Citation Index (ESCI)
SC Pharmacology & Pharmacy
GA 3W2BR
UT WOS:000826864900001
PM 35856136
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Zhu, QF
   Jiang, GJ
   Lang, X
   Zhang, JJ
   Fu, ZC
   Zhang, P
   Zheng, YL
   Zhang, XY
AF Zhu, Quanfeng
   Jiang, Guojun
   Lang, Xiaoe
   Zhang, Jianjun
   Fu, Zhengchuang
   Zhang, Peng
   Zheng, Yali
   Zhang, Xiang-Yang
TI Prevalence and clinical correlates of thyroid dysfunction in
   first-episode and drug-naive major depressive disorder patients with
   metabolic syndrome
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE First-episode; Drug-naive; Major depressive disorder; Metabolic
   syndrome; Thyroid dysfunction
ID OBESITY; ASSOCIATION; HYPOTHALAMUS; AUTOIMMUNITY; INFLAMMATION; HORMONES
AB Background: Few studies have investigated the relative factors of thyroid dysfunction in major depressive disorder (MDD) patients with Metabolic syndrome (MetS). This study aimed to explore the prevalence and related factors associated with thyroid dysfunction in drug-naive (FEDN) MDD patients with MetS.Methods: 1718 FEDN MDD patients were recruited and their demographic data, clinical data were collected. Various biochemical indicators including fasting blood glucose (FBG), blood lipids and thyroid hormones were measured. The 17-item Hamilton Rating Scale for Depression (HAMD-17), 14-item Hamilton Anxiety Rating Scale (HAMA-14) and positive subscale of the Positive and Negative Syndrome Scale (PANSS) were used to assess clinical symptoms.Results: Among FEDN MDD patients, MetS was an independent risk factor for TSH abnormality (P < 0.001, Adjusted OR = 3.77, 95%CI: 2.82-5.05). In patients with MetS, those with TSH abnormality had significantly longer duration of illness, higher HAMD, HAMA, and PANSS positive subscale scores, higher levels of TC, LDL-C, blood glucose, pressure, lower levels of HDL-C, and a higher probability of suicide attempt (all P < 0.01).Conclusions: MetS is significantly associated with thyroid dysfunction in patients with FEDN MDD. Related factors for thyroid dysfunction include a number of clinical indicators and psychiatric symptoms.
C1 [Zhu, Quanfeng; Jiang, Guojun; Fu, Zhengchuang; Zhang, Peng; Zheng, Yali] Hangzhou Normal Univ, Affiliated Xiaoshan Hosp, Hangzhou, Peoples R China.
   [Lang, Xiaoe] Shanxi Med Univ, Hosp 1, Dept Psychiat, First Clin Med Coll, Taiyuan, Peoples R China.
   [Zhang, Jianjun; Zhang, Xiang-Yang] Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China.
   [Zhang, Jianjun; Zhang, Xiang-Yang] Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China.
   [Zhang, Xiang-Yang] 16 Lincui Rd, Beijing 100101, Peoples R China.
C3 Hangzhou Normal University; Shanxi Medical University; Chinese Academy
   of Sciences; University of Chinese Academy of Sciences, CAS
RP Zhang, XY (corresponding author), 16 Lincui Rd, Beijing 100101, Peoples R China.
EM zhangxy@psych.ac.cn
RI Zhang, Xiangyang/ABC-7380-2022; Zhang, Peng/V-8552-2019
OI Zhang, Xiangyang/0000-0003-3326-382X
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NR 45
TC 6
Z9 6
U1 1
U2 7
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD NOV 15
PY 2023
VL 341
BP 35
EP 41
DI 10.1016/j.jad.2023.08.103
EA AUG 2023
PG 7
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA S5UI2
UT WOS:001071810400001
PM 37633524
DA 2025-06-11
ER

PT J
AU Boehncke, WH
   Boehncke, S
AF Boehncke, Wolf-Henning
   Boehncke, Sandra
TI More than skin-deep: the many dimensions of the psoriatic disease
SO SWISS MEDICAL WEEKLY
LA English
DT Review
DE psoriasis; comorbidities; mortality; insulin resistance; screening;
   management
ID METABOLIC SYNDROME; COMORBIDITY; PREVALENCE; LOCI; IDENTIFICATION;
   EPIDEMIOLOGY; MORTALITY; IL12B; IL23R; RISK
AB Psoriasis is among the most common skin diseases, exhibiting a wide spectrum of clinical manifestations. Joint involvement in the form of psoriatic arthritis is readily recognised, but both frequency and severity of this manifestation have long been underestimated. More recently, additional important diseases have been found to be associated with psoriasis, including the metabolic syndrome (or components thereof), cardiovascular diseases, lymphoma, and anxiety/depression. In the past, psoriasis treatment aimed at suppressing acute rashes. Current concepts regard psoriasis as a chronic systemic inflammatory condition and cardiovascular risk factor. In the light of this concept, longterm disease control through systemic maintenance therapy is increasingly recommended by experts. This approach became feasible with the approval of numerous biologics for the treatment of psoriasis. But to really address all medical needs of psoriasis patients, a truly interdisciplinary, comprehensive management approach is needed. Several national societies have already published algorithms to ensure that this need will be implemented in the daily practice of dermatologists and nondermatologists alike.
C1 [Boehncke, Wolf-Henning] Univ Hosp Geneva, Dept Dermatol & Venereol, Geneva, Switzerland.
   [Boehncke, Sandra] Univ Hosp Geneva, Dept Diabetol Endocrinol Hypertens & Nutr, Geneva, Switzerland.
C3 University of Geneva; University of Geneva
RP Boehncke, WH (corresponding author), Hop Univ Geneve, Serv Dermatol & Venerol, Rue Gabrielle Perret Gentil 4, CH-1211 Geneva 14, Switzerland.
EM wolf-henning.boehncke@hcuge.ch
OI Boehncke, Wolf-Henning/0000-0002-1225-7124
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NR 45
TC 23
Z9 26
U1 0
U2 5
PU E M H SWISS MEDICAL PUBLISHERS LTD
PI MUTTENZ
PA FARNSBURGERSTR 8, CH-4132 MUTTENZ, SWITZERLAND
SN 1424-7860
EI 1424-3997
J9 SWISS MED WKLY
JI Swiss Med. Wkly.
PD APR 24
PY 2014
VL 144
AR w13968
DI 10.4414/smw.2014.13968
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA AK6QS
UT WOS:000338552900003
PM 24764145
OA Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Kim, MH
   Lee, HS
   Park, HJ
   Kim, WY
AF Kim, M. H.
   Lee, H. S.
   Park, H. J.
   Kim, Wha Young
TI Risk factors associated with metabolic syndrome in Korean elderly
SO ANNALS OF NUTRITION AND METABOLISM
LA English
DT Article
DE metabolic syndrome; immune function; antioxidant capacity; nutritional
   factor; elderly people
ID INSULIN-RESISTANCE; OXIDATIVE STRESS; SYNDROME-X; INFLAMMATION; DIET;
   PREVALENCE; PLASMA; CHOLESTEROL; BIOMARKERS; MARKERS
AB Objective: The aim of our study was to identify risk factors related to the prevalence of metabolic syndrome (MetS) in the Korean elderly population. Methods: This cross-sectional study was conducted with 404 Korean elderly subjects (118 male, 286 female), aged 60 years or older between 2000 and 2003. The subjects were divided into MetS and control groups based on Adult Treatment Panel III guidelines and by applying the Asia-Pacific waist circumference. Dietary intake, blood profiles, and anthropometric variables were measured. Results: The MetS group had a significantly higher serum triglyceride level (p < 0.001) than the control group. The risk of the MetS was inversely associated with the intake of protein, fat, vitamin A, and vitamin E in women. Plasma levels of interleukin-1RA were higher in the MetS group (p < 0.05); however, interleukin-2 levels were not significantly different. Plasma antioxidant vitamin levels tended to be lower in the MetS group and were negatively associated with the risk factors of MetS. Conclusion: Korean elderly subjects with MetS tended to have an increased inflammatory response and a decreased antioxidant capacity. Furthermore, it was identified that undernutrition (especially a deficiency of antioxidant vitamins), not excess intake of energy, fat, or cholesterol, was associated with risk for MetS. Copyright (c) 2008 S. Karger AG, Basel.
C1 [Park, H. J.; Kim, Wha Young] Ewha Womans Univ, Dept Nutr Sci & Food Management, Seoul 120750, South Korea.
   [Kim, M. H.] Kyungpook Natl Univ, Dept Food & Nutr, Taegu 702701, South Korea.
   [Lee, H. S.] Seoul Sports Grad Univ, Dept Sports Sci, Seoul, South Korea.
C3 Ewha Womans University; Kyungpook National University (KNU)
RP Kim, WY (corresponding author), Ewha Womans Univ, Dept Nutr Sci & Food Management, 11-1 Daehyun Dong,Seodaemun Gu, Seoul 120750, South Korea.
EM wykim@ewha.ac.kr
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NR 36
TC 15
Z9 17
U1 0
U2 2
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0250-6807
EI 1421-9697
J9 ANN NUTR METAB
JI Ann. Nutr. Metab.
PY 2007
VL 51
IS 6
BP 533
EP 540
DI 10.1159/000112977
PG 8
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 263WU
UT WOS:000253248000030
PM 18185016
DA 2025-06-11
ER

PT J
AU Imae, M
   Asano, T
   Murakami, S
AF Imae, Masato
   Asano, Toshiki
   Murakami, Shigeru
TI Potential role of taurine in the prevention of diabetes and metabolic
   syndrome
SO AMINO ACIDS
LA English
DT Review
DE Taurine; Diabetes; Metabolic syndrome
ID SPONTANEOUSLY HYPERTENSIVE-RATS; HIGH-CHOLESTEROL DIET;
   SYMPATHETIC-NERVE ACTIVITY; INDUCED INSULIN-RESISTANCE; OXIDATIVE
   STRESS; ALVEOLAR MACROPHAGES; NUTRITIONAL FACTOR; N-ACETYLCYSTEINE;
   PLATELET TAURINE; ANGIOTENSIN-II
AB Metabolic syndrome is characterized by the cluster of a number of metabolic abnormalities in the presence of underlying insulin resistance. The prevalence of metabolic syndrome has steadily increased in all populations worldwide. Taurine (2-aminoethanesulfonic acid) is a sulfur-containing amino acid that is involved in a variety of physiological functions. Clinical and experimental studies show that taurine intake may be beneficial in the prevention of metabolic syndrome including diabetes, obesity, dyslipidemia, and hypertension. This article reviews the effect of taurine on all of the components of metabolic syndrome. In addition, the possible mechanisms by which taurine prevents diabetes and metabolic syndrome are also discussed. Further study is needed to determine the role of taurine in the development of metabolic syndrome in humans, because there is presently limited clinical data available.
C1 [Imae, Masato; Asano, Toshiki] Taisho Pharmaceut Co Ltd, R&D Labs, Self Medicat Business, Kita Ku, Saitama 3319530, Japan.
   [Murakami, Shigeru] Taisho Pharmaceut Co Ltd, R&D Headquarters, Self Medicat Business, Toshima Ku, Tokyo 1708633, Japan.
C3 Taisho Pharmaceutical Holdings Co Ltd; Taisho Pharmaceutical Holdings Co
   Ltd
RP Murakami, S (corresponding author), Taisho Pharmaceut Co Ltd, R&D Headquarters, Self Medicat Business, Toshima Ku, 24-1 Takada 3 Chome, Tokyo 1708633, Japan.
EM s-murakami@so.taisho.co.jp
OI Asano, Toshiki/0000-0003-3713-1832
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NR 84
TC 63
Z9 65
U1 1
U2 46
PU SPRINGER WIEN
PI WIEN
PA SACHSENPLATZ 4-6, PO BOX 89, A-1201 WIEN, AUSTRIA
SN 0939-4451
EI 1438-2199
J9 AMINO ACIDS
JI Amino Acids
PD JAN
PY 2014
VL 46
IS 1
BP 81
EP 88
DI 10.1007/s00726-012-1434-4
PG 8
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 294GQ
UT WOS:000330032700008
PM 23224909
DA 2025-06-11
ER

PT J
AU Koegelenberg, ASE
   Schutte, R
   Smith, W
   Schutte, AE
AF Koegelenberg, A. S. E.
   Schutte, R.
   Smith, W.
   Schutte, A. E.
TI Bioavailable IGF-1 and its Relation to the Metabolic Syndrome in a
   Bi-Ethnic Population of Men and Women
SO HORMONE AND METABOLIC RESEARCH
LA English
DT Article
DE metabolic syndrome; insulin-like growth factor binding protein-3;
   inflammation; oxidative stress; gamma-glutamyltransferase
ID GROWTH-FACTOR-I; C-REACTIVE PROTEIN; OXIDATIVE STRESS; BLOOD-PRESSURE;
   RISK; EXPRESSION; EXERCISE; HEALTH
AB Insulin-like growth factor 1 (IGF-1), an insulin sensitivity and vasculoprotective factor, associates negatively with the metabolic syndrome. However, IGF-1 is reduced by factors such as inflammation, oxidative stress and liver dysfunction. We investigated the relationship between bioavailable IGF-1 and the number of metabolic syndrome components and determined whether this relationship is independent of inflammation, oxidative stress and gamma glutamyl transferase (-GT; a marker of liver dysfunction). This study included 907 black and white participants stratified by sex (aged 43.0 +/- 11.8 years). Among them 63 participants had fasting glucose levels of +7.0+mmol/l and/or used diabetes medication. Via standard methods we determined waist circumference, fasting glucose, triglycerides, high-density lipoprotein cholesterol and blood pressure. We also determined high-sensitivity C-reactive protein (CRP), reactive oxygen species (ROS), -GT, IGF-1 and insulin-like growth factor binding protein 3 (IGFBP-3). IGF-1/IGFBP-3 was used as an estimate of bioavailable IGF-1. Total IGF-1 was similar between men and women (p=0.10), however, bioavailable IGF-1 was lower in women (p<0.001). In multivariate-adjusted analyses, IGF-1/IGFBP-3 was inversely associated with the number of metabolic syndrome components in both sexes (men: =-0.11; p=0.013 and women: =-0.17; p=0.003). Upon inclusion of ROS, -GT and CRP, significance was lost. In patients without diabetes, the results for men changed marginally, but were consistent for women. We found an inverse association between bioavailable IGF-1 and the number of metabolic syndrome components. But the relationship was dependent on oxidative stress, liver dysfunction and inflammation, suggesting underlying processes by which the metabolic syndrome attenuates IGF-1.
C1 [Koegelenberg, A. S. E.; Schutte, R.; Smith, W.; Schutte, A. E.] North West Univ, HART, Private Bag X6001, ZA-2520 Potchefstroom, South Africa.
   [Schutte, R.; Schutte, A. E.] North West Univ, MRC Res Unit Hypertens & Cardiovasc Dis, Potchefstroom, South Africa.
C3 North West University - South Africa; North West University - South
   Africa
RP Schutte, AE (corresponding author), North West Univ, HART, Private Bag X6001, ZA-2520 Potchefstroom, South Africa.
EM alta.schutte@nwu.ac.za
RI Smith, Wayne/HKE-7358-2023; Schutte, Aletta/E-5126-2018
OI Schutte, Aletta/0000-0001-9217-4937; Smith, Wayne/0000-0002-7101-7331
FU Medical Research Council, South Africa; Roche Diagnostics; North-West
   University; Metabolic Syndrome Institute, France; National Research
   Foundation (NRF)
FX The SABPA and SAfrEIC studies would not have been possible without the
   voluntary collaboration of the participants. We gratefully acknowledge
   the contribution of the research teams, and the Department of Education,
   South Africa (SABPA study), for their involvement in these studies.
   Research included in the present study was partially funded by the
   Medical Research Council, South Africa; Roche Diagnostics; the
   North-West University; and the Metabolic Syndrome Institute, France. The
   financial assistance of the National Research Foundation (NRF) towards
   this research is hereby acknowledged. Opinions expressed and conclusions
   arrived at are those of the author and are not necessarily to be
   attributed to the NRF.
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NR 33
TC 4
Z9 4
U1 0
U2 1
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0018-5043
EI 1439-4286
J9 HORM METAB RES
JI Horm. Metab. Res.
PD FEB
PY 2016
VL 48
IS 2
BP 130
EP 136
DI 10.1055/s-0035-1559768
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA DD2DS
UT WOS:000369733300009
PM 26348017
DA 2025-06-11
ER

PT J
AU Lautt, WW
   Ming, Z
   Macedo, MP
   Legare, DJ
AF Lautt, W. Wayne
   Ming, Zhi
   Macedo, M. Paula
   Legare, Dallas J.
TI HISS-dependent insulin resistance (HDIR) in aged rats is associated with
   adiposity, progresses to syndrome X, and is attenuated by a unique
   antioxidant cocktail
SO EXPERIMENTAL GERONTOLOGY
LA English
DT Article
DE antioxidant vitamins; age; regional adiposity; body weight; HISS
ID AUTONOMIC NERVOUS-SYSTEM; SENSITIVITY TEST RIST; HEART-RATE-VARIABILITY;
   VISCERAL FAT; S-ADENOSYLMETHIONINE; METABOLIC SYNDROME; OXIDATIVE
   STRESS; LIVER; GLUTATHIONE; INTERRUPTION
AB The hypotheses were: HISS-dependent insulin resistance (HDIR) accounts for insulin resistance that occurs with aging; HDIR is the initiating metabolic defect that leads progressively to type 2 diabetes and the metabolic syndrome; a synergistic antioxidant cocktail in chow confers protection against HDIR, Subsequent symptoms ofdiabetes, and the metabolic syndrome. Male Sprague Dawley rats were tested at 9, 26, and 52 weeks to determine their dynamic response to insulin, the HISS (hepatic insulin sensitizing substance)-dependent component of insulin action, and the HISS-independent (direct) insulin action using a dynamic insulin sensitivity test. in young rats, the HISS component accounted for 52.3 + 2.1% of the response to a bolus of insulin (50 mU/kg) which decreased to 29.8 3.4% at 6 months and 17.0 + 2.7% at 12 months. HISS action correlated negatively with whole body adiposity and all regional fat depots (r(2) = 0.67-0.87). The antioxidants (vitamin C, vitamin E, and S-adenosylmethionine) conferred protection of HISS action, fat mass at all sites, blood pressure, postprandial insulin and glucose. Data are consistent with the hypotheses. Early detection and therapy directed towards treatment of HDIR offers a novel therapeutic target. (c) 2008 Elsevier Inc. All rights reserved.
C1 [Lautt, W. Wayne; Ming, Zhi; Legare, Dallas J.] Univ Manitoba, Fac Med, Dept Pharmacol & Therapeut, Winnipeg, MB R3E 0T6, Canada.
   [Macedo, M. Paula] Univ Nova Lisboa, Dept Physiol, Fac Med Sci, P-1169056 Lisbon, Portugal.
C3 University of Manitoba; Universidade Nova de Lisboa
RP Lautt, WW (corresponding author), Univ Manitoba, Fac Med, Dept Pharmacol & Therapeut, A210 753 McDermot Ave, Winnipeg, MB R3E 0T6, Canada.
EM wlautt@cc.umanitoba.ca
RI Legare, Dallas/AAC-3234-2021; Macedo, Maria/Q-7827-2018; Lautt,
   W./AAC-6106-2021
OI Lautt, W. Wayne/0000-0002-7239-1798; Macedo, Maria
   Paula/0000-0002-2549-0275
FU Canadian Institutes of Health Research; Manitoba Health Research Council
   Regional Partnership Program
FX This study was funded by operating grants from the Canadian Institutes
   of Health Research and the Manitoba Health Research Council Regional
   Partnership Program. Manuscript preparation was by Karen Sanders. We
   acknowledge the excellent daily and long term care and monitoring of the
   animals provided by Gerry Nolette and the staff of Central Animal Care
   Services at the University of Manitoba.Related Interests: Lautt and Ming
   are inventors on a patent for the synergistic combination of
   S-adenosylmethionine, vitamin E, and vitamin C (Samec) which is licensed
   to DiaMedica Inc., Winnipeg, Manitoba, Canada.
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NR 60
TC 19
Z9 25
U1 0
U2 3
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0531-5565
J9 EXP GERONTOL
JI Exp. Gerontol.
PD AUG
PY 2008
VL 43
IS 8
BP 790
EP 800
DI 10.1016/j.exger.2008.04.013
PG 11
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA 343LQ
UT WOS:000258855700011
PM 18538970
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Radford-Smith, DE
   Patel, PJ
   Irvine, KM
   Russell, A
   Siskind, D
   Anthony, DC
   Powell, EE
   Probert, F
AF Radford-Smith, Daniel E.
   Patel, Preya J.
   Irvine, Katharine M.
   Russell, Anthony
   Siskind, Dan
   Anthony, Daniel C.
   Powell, Elizabeth E.
   Probert, Fay
TI Depressive symptoms in non-alcoholic fatty liver disease are identified
   by perturbed lipid and lipoprotein metabolism
SO PLOS ONE
LA English
DT Article
ID ASSOCIATIONS; SEVERITY; GLYCA
AB Non-alcoholic fatty liver disease (NAFLD) and depression are common disorders and have bidirectional contributing relationships to metabolic syndrome. We aimed to determine whether a fasting serum signature of recent, self-reported depressive symptoms could be identified in a heterogeneous NAFLD cohort using nuclear magnetic resonance (NMR)-based metabolomics integrated with clinical chemistry. Serum nuclear magnetic resonance (NMR) metabolite profiles and corresponding clinical chemistry were compared between patients with depressive symptoms in the last 12-months (n = 81) and patients without recent depressive symptoms (n = 137 controls) using multivariate statistics. Orthogonal partial least squares discriminant analysis (OPLS-DA) of the biochemical and metabolomic data identified NAFLD patients with recent depression with a cross-validated accuracy of 61.5%, independent of age, sex, medication, and other comorbidities. This led to the development of a diagnostic algorithm with AUC 0.83 for future testing in larger clinical cohorts. Serum triglycerides, VLDL cholesterol, and the inflammatory biomarker GlycA were key metabolites increased in patients with recent depressive symptoms, while serum glutamine level was reduced. Here, serum NMR metabolite analysis provides a link between disturbed lipid metabolism, inflammation, and active mental health issues in NAFLD, irrespective of disease severity.
C1 [Radford-Smith, Daniel E.; Anthony, Daniel C.] Univ Oxford, Dept Pharmacol, Oxford, England.
   [Radford-Smith, Daniel E.; Probert, Fay] Univ Oxford, Dept Chem, Oxford, England.
   [Radford-Smith, Daniel E.] Univ Oxford, Warneford Hosp, Dept Psychiat, Oxford, England.
   [Patel, Preya J.] UCL, Inst Liver & Digest Hlth, London, England.
   [Patel, Preya J.] Newcastle Upon Tyne Hosp NHS Fdn Trust, Liver Unit, Newcastle Upon Tyne, Tyne & Wear, England.
   [Irvine, Katharine M.; Powell, Elizabeth E.] Univ Queensland, Ctr Liver Dis Res, Brisbane, Qld, Australia.
   [Irvine, Katharine M.] Univ Queensland, Mater Res, Brisbane, Qld, Australia.
   [Russell, Anthony] Princess Alexandra Hosp, Dept Diabet & Endocrinol, Brisbane, Qld, Australia.
   [Russell, Anthony] Univ Queensland, Ctr Hlth Serv Res, Brisbane, Qld, Australia.
   [Siskind, Dan] Univ Queensland, Sch Clin Med, Woolloongabba, Qld, Australia.
   [Siskind, Dan] Metro South Addict & Mental Hlth Serv, Woolloongabba, Qld, Australia.
   [Powell, Elizabeth E.] Princess Alexandra Hosp, Dept Gastroenterol & Hepatol, Brisbane, Qld, Australia.
C3 University of Oxford; University of Oxford; University of Oxford;
   University of London; University College London; Newcastle Upon Tyne
   Hospitals NHS Foundation Trust; University of Queensland; University of
   Queensland; Mater Research; Princess Alexandra Hospital; University of
   Queensland; University of Queensland; Princess Alexandra Hospital
RP Radford-Smith, DE (corresponding author), Univ Oxford, Dept Pharmacol, Oxford, England.; Radford-Smith, DE (corresponding author), Univ Oxford, Dept Chem, Oxford, England.; Radford-Smith, DE (corresponding author), Univ Oxford, Warneford Hosp, Dept Psychiat, Oxford, England.
EM daniel.radford-smith@pharm.ox.ac.uk
RI Radford-Smith, Daniel/IUQ-7645-2023; Russell, Anthony/A-8807-2011;
   Irvine, Katharine/A-5559-2011; Powell, Elizabeth/B-4455-2011; Siskind,
   Dan/A-9812-2014; Anthony, Daniel/ITT-4206-2023
OI Russell, Anthony/0000-0001-7886-8844; Irvine,
   Katharine/0000-0002-6716-1605; Powell, Elizabeth/0000-0001-5008-8061;
   Patel, Preya/0000-0002-2433-6794; Probert, Fay/0000-0002-8580-2023;
   Siskind, Dan/0000-0002-2072-9216; Anthony, Daniel/0000-0003-1380-6655
FU Lincoln College, University of Oxford; Oxford University Press Clarendon
   Scholarship; Newton Abraham Studentship, University of Oxford
FX Lincoln College, University of Oxford (Daniel Radford-Smith): General
   financial support for DPhil (bursary and laboratory bench fees). Oxford
   University Press Clarendon Scholarship (Daniel Radford-Smith): General
   financial support for DPhil (bursary and laboratory bench fees). Newton
   Abraham Studentship, University of Oxford (Daniel Radford-Smith):
   General financial support for DPhil (bursary and laboratory bench fees).
   No other funds contributed to this study. All other authors do not
   declare any funding for this study. The funders had no role in study
   design, data collection and analysis, decision to publish, or
   preparation of the manuscript.
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NR 31
TC 6
Z9 7
U1 4
U2 10
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JAN 6
PY 2022
VL 17
IS 1
AR e0261555
DI 10.1371/journal.pone.0261555
PG 13
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 2J6SK
UT WOS:000815783800010
PM 34990473
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Guarnieri, G
   Zanetti, M
   Vinci, P
   Cattin, MR
   Pirulli, A
   Barazzoni, R
AF Guarnieri, Gianfranco
   Zanetti, Michela
   Vinci, Pierandrea
   Cattin, Maria Rosa
   Pirulli, Alesia
   Barazzoni, Rocco
TI Metabolic Syndrome and Chronic Kidney Disease
SO JOURNAL OF RENAL NUTRITION
LA English
DT Article; Proceedings Paper
CT 6th International Congress on Uremia Research and Toxicity
CY MAY 18-19, 2009
CL Poiana Brasov, ROMANIA
ID MUSCLE PROTEIN-DEGRADATION; INSULIN-RESISTANCE; OXIDATIVE STRESS;
   SKELETAL-MUSCLE; INTRAABDOMINAL FAT; GENE-EXPRESSION; PLASMA GHRELIN;
   POTENTIAL ROLE; VITAMIN-C; OBESITY
AB Obesity is a global health threat because of its associated metabolic and cardiovascular complications. Metabolic and hemodynamic complications of obesity (insulin resistance and hyperglycemia, hypertension, atherogenic dysli-pidemia) are often clustered in the metabolic syndrome, leading to high cardiovascular morbidity and mortality. In recent years, epidemiological studies have clearly indicated that both obesity and the metabolic syndrome are independent risk factors for chronic kidney disease and these associations are at least in part independent of diabetes and hypertension per se. Additional mechanisms associated with obesity and metabolic syndrome leading to reduced renal function may include altered levels of adipose tissue hormones, inflammation, and oxidative stress. The ongoing worldwide obesity epidemic is therefore likely to increase the number of patients with chronic uremia and features of the metabolic syndrome in the next few years. Moreover, the onset and maintenance of renal damage may worsen metabolic syndrome features including insulin resistance and hypertension, leading to potential vicious cycles with negative clinical effect. Further understanding of the interactions between obesity, metabolic syndrome, and chronic kidney disease represents a potential strategy to design more effective treatments aimed at reducing morbidity and mortality in uremic patients. (C) 2010 by the National Kidney Foundation, Inc. All rights reserved.
C1 [Guarnieri, Gianfranco; Zanetti, Michela; Vinci, Pierandrea; Cattin, Maria Rosa; Pirulli, Alesia; Barazzoni, Rocco] Univ Trieste, Med Clin, Dept MTTS, Trieste, Italy.
C3 University of Trieste
RP Guarnieri, G (corresponding author), Osped Cattinara, Med Clin, Str Fiume 447, I-34100 Trieste, Italy.
EM guarnier@units.it
RI Guarnieri, Giovanni/ABE-8112-2020
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NR 52
TC 25
Z9 30
U1 0
U2 4
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 1051-2276
EI 1532-8503
J9 J RENAL NUTR
JI J. Renal Nutr.
PD SEP
PY 2010
VL 20
IS 5
SU 1
BP S19
EP S23
DI 10.1053/j.jrn.2010.05.006
PG 5
WC Nutrition & Dietetics; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Nutrition & Dietetics; Urology & Nephrology
GA 642KP
UT WOS:000281212400006
PM 20797564
DA 2025-06-11
ER

PT J
AU Kemp, DE
   Schinagle, M
   Gao, KM
   Conroy, C
   Ganocy, SJ
   Ismail-Beigi, F
   Calabrese, JR
AF Kemp, David E.
   Schinagle, Martha
   Gao, Keming
   Conroy, Carla
   Ganocy, Stephen J.
   Ismail-Beigi, Faramarz
   Calabrese, Joseph R.
TI PPAR-γ Agonism as a Modulator of Mood: Proof-of-Concept for Pioglitazone
   in Bipolar Depression
SO CNS DRUGS
LA English
DT Article
ID PLACEBO-CONTROLLED TRIAL; YOUNG-ADULT MALES; INSULIN-RESISTANCE;
   DOUBLE-BLIND; METABOLIC SYNDROME; I DEPRESSION; BIDIRECTIONAL
   ASSOCIATION; INFLAMMATORY CYTOKINES; ADJUNCTIVE THERAPY;
   GLUCOSE-TOLERANCE
AB Insulin resistance and other cardio-metabolic risk factors predict increased risk of depression and decreased response to antidepressant and mood stabilizer treatments. This proof-of-concept study tested whether administration of an insulin-sensitizing peroxisome proliferator-activated receptor (PPAR)-gamma agonist could reduce bipolar depression symptom severity. A secondary objective was to determine whether levels of highly sensitive C-reactive protein and interleukin (IL)-6 predicted treatment outcome.
   Patients (n = 34) with bipolar disorder (I, II, or not otherwise specified) and metabolic syndrome/insulin resistance who were currently depressed (Quick Inventory of Depressive Symptoms [QIDS] total score a parts per thousand yen11) despite an adequate trial of a mood stabilizer received open-label, adjunctive treatment with the PPAR-gamma agonist pioglitazone (15-30 mg/day) for 8 weeks. The majority of participants (76 %, n = 26) were experiencing treatment-resistant bipolar depression, having already failed two mood stabilizers or the combination of a mood stabilizer and a conventional antidepressant.
   Supporting an association between insulin sensitization and depression severity, pioglitazone treatment was associated with a decrease in the total Inventory of Depressive Symptomatology (IDS-C30) score from 38.7 +/- A 8.2 at baseline to 21.2 +/- A 9.2 at week 8 (p < 0.001). Self-reported depressive symptom severity and clinician-rated anxiety symptom severity significantly improved over 8 weeks as measured by the QIDS (p < 0.001) and Structured Interview Guide for the Hamilton Anxiety Scale (p < 0.001), respectively. Functional improvement also occurred as measured by the change in total score on the Sheehan Disability Scale (-17.9 +/- A 3.6; p < 0.001). Insulin sensitivity increased from baseline to week 8 as measured by the Insulin Sensitivity Index derived from an oral glucose tolerance test (0.98 +/- A 0.3; p < 0.001). Higher baseline levels of IL-6 were associated with greater decrease in depression severity (parameter estimate beta = -3.89, standard error [SE] = 1.47, p = 0.015). A positive correlation was observed between improvement in IDS-C30 score and change in IL-6 (r = 0.44, p < 0.01).
   Open-label administration of the PPAR-gamma agonist pioglitazone was associated with improvement in depressive symptoms and reduced cardio-metabolic risk. Reduction in inflammation may represent a novel mechanism by which pioglitazone modulates mood. (ClinicalTrials.gov Identifier: NCT00835120).
C1 [Kemp, David E.; Schinagle, Martha; Gao, Keming; Conroy, Carla; Ganocy, Stephen J.; Calabrese, Joseph R.] Case Western Reserve Univ, Univ Hosp Case Med Ctr, Cleveland, OH 44106 USA.
   [Ismail-Beigi, Faramarz] Univ Hosp Cleveland, Dept Med, Cleveland, OH 44106 USA.
   [Ismail-Beigi, Faramarz] Cleveland VA Med Ctr, Cleveland, OH USA.
C3 University System of Ohio; Case Western Reserve University; Case Western
   Reserve University Hospital; University Hospitals of Cleveland;
   University System of Ohio; Case Western Reserve University; US
   Department of Veterans Affairs; Veterans Health Administration (VHA);
   Louis Stokes Cleveland Veterans Affairs Medical Center
RP Kemp, DE (corresponding author), Case Western Reserve Univ, Univ Hosp Case Med Ctr, 10524 Euclid Ave,12th Floor, Cleveland, OH 44106 USA.
EM kemp.david@gmail.com
RI Gao, Keming/W-6017-2019
FU Cleveland Foundation; Brain and Behavior Research Foundation; National
   Institutes of Health (NIH) [1KL2RR024990]; National Center for Research
   Resources (NCRR), a component of the NIH [UL1 RR024989]
FX This study was funded in part by the Cleveland Foundation, the National
   Alliance for Research on Schizophrenia and Depression (NARSAD; now known
   as the Brain and Behavior Research Foundation), and National Institutes
   of Health (NIH) grant 1KL2RR024990 to Dr. Kemp. Study medication was
   partially supplied by Takeda Pharmaceuticals. The project described was
   supported by Grant Number UL1 RR024989 from the National Center for
   Research Resources (NCRR), a component of the NIH. The content of this
   article is solely the responsibility of the authors and does not
   necessarily represent the official view of NCRR or NIH.
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NR 61
TC 88
Z9 90
U1 0
U2 13
PU ADIS INT LTD
PI NORTHCOTE
PA 5 THE WAREHOUSE WAY, NORTHCOTE 0627, AUCKLAND, NEW ZEALAND
SN 1172-7047
EI 1179-1934
J9 CNS DRUGS
JI CNS Drugs
PD JUN
PY 2014
VL 28
IS 6
BP 571
EP 581
DI 10.1007/s40263-014-0158-2
PG 11
WC Clinical Neurology; Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA AT0FT
UT WOS:000344613300007
PM 24715548
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Nakagawa, H
   Isogawa, A
   Tateishi, R
   Tani, M
   Yoshida, H
   Yamakado, M
   Koike, K
AF Nakagawa, Hayato
   Isogawa, Akihiro
   Tateishi, Ryosuke
   Tani, Mizuki
   Yoshida, Haruhiko
   Yamakado, Minoru
   Koike, Kazuhiko
TI Serum gamma-glutamyltransferase level is associated with serum
   superoxide dismutase activity and metabolic syndrome in a Japanese
   population
SO JOURNAL OF GASTROENTEROLOGY
LA English
DT Article
DE Gamma-glutamyltransferase; Superoxide dismutase; Lipid peroxide;
   Metabolic syndrome; Atherosclerosis
ID CANCER INCIDENCE; MORTALITY RISK; TRANSPEPTIDASE; ALCOHOL; DEFICIENCY;
   MARKER; HEART; MEN
AB Serum gamma-glutamyltransferase level has attracted considerable attention as a predictor of various conditions, such as cardiovascular disease and cancer. Although the mechanism that links the serum gamma-glutamyltransferase level to these diseases is not fully understood, one explanation is that gamma-glutamyltransferase may be closely related to oxidative stress. We conducted a large cross-sectional study to evaluate the relationship between serum gamma-glutamyltransferase and oxidative stress.
   We examined anti-oxidative stress activity and accumulation of oxidative stress in serum obtained from 2907 subjects who underwent a complete health check-up. We used serum total superoxide dismutase activity as an index of anti-oxidative stress activity. Superoxide dismutase is one of the most important intracellular and extracellular defense systems against superoxide, but the relationship between serum superoxide dismutase activity and the serum gamma-glutamyltransferase level is unclear.
   The serum gamma-glutamyltransferase level was negatively correlated with serum superoxide dismutase activity, a correlation that was observed even within the normal range. A subgroup analysis stratified by the amount of alcohol consumed also showed a similar correlation. In contrast, the serum gamma-glutamyltransferase level was positively correlated with serum lipid peroxide level, even in the normal range. Furthermore, an increased serum gamma-glutamyltransferase level was significantly associated with the progression of metabolic syndrome and carotid artery intima-media thickness.
   The serum gamma-glutamyltransferase level, even in the normal range, was significantly associated with anti-oxidative stress activity, the accumulation of oxidative stress, metabolic syndrome, and atherosclerosis. Measuring the serum gamma-glutamyltransferase level is simple and inexpensive, and this level can be used as a sensitive marker of oxidative stress and metabolic syndrome.
C1 [Nakagawa, Hayato; Tateishi, Ryosuke; Yoshida, Haruhiko; Koike, Kazuhiko] Univ Tokyo, Dept Gastroenterol, Bunkyo Ku, Tokyo 1138655, Japan.
   [Nakagawa, Hayato; Tani, Mizuki; Yamakado, Minoru] Mitsui Mem Hosp, Ctr Multiphas Hlth Testing & Serv, Chiyoda Ku, Tokyo 1018643, Japan.
   [Isogawa, Akihiro] Mitsui Mem Hosp, Dept Internal Med, Chiyoda Ku, Tokyo 1018643, Japan.
C3 University of Tokyo; Mitsui Memorial Hospital; Mitsui Memorial Hospital
RP Nakagawa, H (corresponding author), Univ Tokyo, Dept Gastroenterol, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1138655, Japan.
EM n-hayato@yf7.so-net.ne.jp
RI Nakagawa, Hayato/I-2837-2012; Tateishi, Ryosuke/G-7758-2014
OI Tateishi, Ryosuke/0000-0003-3021-2517; Nakagawa,
   Hayato/0000-0002-6973-5094
FU Ministry of Health, Labour and Welfare of Japan [H20-kannenn-008]
FX This work was supported by Grants-in-Aid from the Ministry of Health,
   Labour and Welfare of Japan (H20-kannenn-008).
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NR 28
TC 12
Z9 14
U1 0
U2 6
PU SPRINGER JAPAN KK
PI TOKYO
PA SHIROYAMA TRUST TOWER 5F, 4-3-1 TORANOMON, MINATO-KU, TOKYO, 105-6005,
   JAPAN
SN 0944-1174
EI 1435-5922
J9 J GASTROENTEROL
JI J. Gastroenterol.
PD FEB
PY 2012
VL 47
IS 2
BP 187
EP 194
DI 10.1007/s00535-011-0477-8
PG 8
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 895RL
UT WOS:000300513900011
PM 21976134
DA 2025-06-11
ER

PT J
AU Palacio, TLN
   Siqueira, JS
   de Paula, BH
   Rego, RMP
   Vieira, TA
   Baron, G
   Altomare, A
   Ferron, AJT
   Aldini, G
   Kano, HT
   Correa, CR
AF Palacio, Thiago Luiz Novaga
   Siqueira, Juliana Silva
   de Paula, Bruno Henrique
   Rego, Rebeca Mayara Padilha
   Vieira, Taynara Aparecida
   Baron, Giovanna
   Altomare, Alessandra
   Ferron, Artur Junio Togneri
   Aldini, Giancarlo
   Kano, Hugo Tadashi
   Correa, Camila Renata
TI Bergamot (Citrus bergamia) leaf extract improves metabolic,
   antioxidant and anti-inflammatory activity in skeletal muscles in a
   metabolic syndrome experimental model
SO INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION
LA English
DT Article
DE Metabolic syndrome; bioactive compounds; oxidative stress; inflammation
ID INSULIN; OBESITY; LIVER; INFLAMMATION
AB Metabolic Syndrome (MetS), inflammation and oxidative stress contribute to impairment of skeletal muscle function. Bergamot (Citrus bergamia) leaf extract (BLE) has shown protective effects against comorbidities associated with MetS through its anti-inflammatory and antioxidant effects. The aim of this work was to elucidate the antioxidant and anti-inflammatory activity of BLE in skeletal muscles in an experimental model of MetS. Once metabolic syndrome was diagnosed, animals were divided into groups receiving different treatments for 10 weeks, including control diet (n = 10), control + BLE (n = 10), High Sugar-fat diet (HSF) (n = 10), HSF + BLE (n = 10). Evaluation included nutritional, metabolic and hormonal analyses, along with measurements of inflammatory status and oxidative stress in soleus and extensor digitorum longus (EDL) muscles. BLE showed positive metabolic effects, with a reduction of plasma triglycerides and insulin resistance and an increase in high-density lipoprotein cholesterol, and protective activity against oxidative stress and inflammation in Soleus and EDL muscles in animals with MetS.
C1 [Palacio, Thiago Luiz Novaga; Siqueira, Juliana Silva; de Paula, Bruno Henrique; Rego, Rebeca Mayara Padilha; Vieira, Taynara Aparecida; Ferron, Artur Junio Togneri; Kano, Hugo Tadashi; Correa, Camila Renata] Sao Paulo State Univ UNESP, Med Sch, Botucatu, Brazil.
   [Baron, Giovanna; Altomare, Alessandra; Aldini, Giancarlo] Univ Milan, Dept Pharmaceut Sci, Milan, Italy.
   [Ferron, Artur Junio Togneri] Integrated Coll Bauru FIB, Dept Phys Educ, Bauru, Brazil.
   [Siqueira, Juliana Silva] Sao Paulo State Univ UNESP, Botucatu Med Sch, Prof Montenegro Ave, BR-18618687 Botucatu, Brazil.
C3 Universidade Estadual Paulista; University of Milan; Universidade
   Estadual Paulista
RP Siqueira, JS (corresponding author), Sao Paulo State Univ UNESP, Botucatu Med Sch, Prof Montenegro Ave, BR-18618687 Botucatu, Brazil.
EM juliana.siqueira@unesp.br
RI Siqueira, Juliana/AAR-7994-2021; Correa, Camila/Q-2071-2019; Baron,
   Giovanna/ABE-3121-2020; de Paula, Bruno/ABA-3561-2020; aldini,
   giancarlo/C-3533-2013; Ferron, Artur/M-5194-2017; Aparecida Vieira,
   Taynara/JFK-7958-2023; Novaga Palacio, Thiago Luiz/AGP-5802-2022
OI Baron, Giovanna/0000-0002-9335-6318; Aparecida Vieira,
   Taynara/0000-0002-5312-0060; Correa, Camila Renata/0000-0001-8493-5329;
   Novaga Palacio, Thiago Luiz/0000-0001-9568-7156
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NR 39
TC 9
Z9 9
U1 1
U2 16
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0963-7486
EI 1465-3478
J9 INT J FOOD SCI NUTR
JI Int. J. Food Sci. Nutr.
PD JAN 2
PY 2023
VL 74
IS 1
BP 64
EP 71
DI 10.1080/09637486.2022.2154328
EA DEC 2022
PG 8
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA 9T1LQ
UT WOS:000897982200001
PM 36519349
DA 2025-06-11
ER

PT J
AU Goodwill, AG
   Frisbee, JC
AF Goodwill, Adam G.
   Frisbee, Jefferson C.
TI Oxidant stress and skeletal muscle microvasculopathy in the metabolic
   syndrome
SO VASCULAR PHARMACOLOGY
LA English
DT Review
DE Metabolic syndrome; Vasculopathy; Microcirculation; Oxidant stress
ID ENDOTHELIAL NITRIC-OXIDE; LOW-DENSITY-LIPOPROTEIN;
   TUMOR-NECROSIS-FACTOR; OBESE ZUCKER RATS; GLYCATION END-PRODUCTS;
   MITOCHONDRIAL SUPEROXIDE-PRODUCTION; MONOCYTE CHEMOATTRACTANT PROTEIN-1;
   FATTY-ACID OXIDATION; INSULIN-RESISTANCE; HYDROGEN-PEROXIDE
AB The evolution of the metabolic syndrome in afflicted individuals is, in part, characterized by the development of a severely pro-oxidant state within the vasculature. It has been previously demonstrated by many investigators that this increasingly pro-oxidant state can have severe negative implications for many relevant processes within the vasculature, including the coordination of dilator/constrictor tone or reactivity, the structural adaptations of the vascular wall or distal networks, as well as the integrated regulation of perfusion resistance across and throughout the vascular networks. The purpose of this review article is to present the different sources of oxidant stress within the setting of the metabolic syndrome, the available mechanism for attempts at regulation and the vascular outcomes associated with this condition. It is anticipated that this overview will help readers and investigators to more effectively design experiments and interpret their results within the extremely complicated setting of metabolic syndrome. (C) 2012 Elsevier Inc. All rights reserved.
C1 [Goodwill, Adam G.; Frisbee, Jefferson C.] W Virginia Univ, Sch Med, Dept Physiol & Pharmacol, Morgantown, WV 26506 USA.
   [Goodwill, Adam G.; Frisbee, Jefferson C.] W Virginia Univ, Sch Med, Ctr Cardiovasc & Resp Sci, Morgantown, WV 26506 USA.
C3 West Virginia University; West Virginia University
RP Frisbee, JC (corresponding author), W Virginia Univ, Ctr Interdisciplinary Res Cardiovasc Sci, Robert C Byrd Hlth Sci Ctr, Dept Physiol & Pharmacol,Sch Med, POB 9105, Morgantown, WV 26505 USA.
EM jfrisbee@hsc.wvu.edu
RI ; Goodwill, Adam/N-4889-2016
OI Frisbee, Jefferson/0000-0003-2751-0599; Goodwill,
   Adam/0000-0003-3701-3713
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NR 158
TC 31
Z9 33
U1 1
U2 12
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1537-1891
EI 1879-3649
J9 VASC PHARMACOL
JI Vasc. Pharmacol.
PD NOV-DEC
PY 2012
VL 57
IS 5-6
SI SI
BP 150
EP 159
DI 10.1016/j.vph.2012.07.002
PG 10
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 006YE
UT WOS:000308854900004
PM 22796585
DA 2025-06-11
ER

PT J
AU Nakamura, K
   Yamagishi, S
   Yoshida, T
   Matsui, T
   Imaizumi, T
   Inoue, H
   Sata, M
AF Nakamura, K.
   Yamagishi, S.
   Yoshida, T.
   Matsui, T.
   Imaizumi, T.
   Inoue, H.
   Sata, M.
TI Hydrogen peroxide stimulates pigment epithelium-derived factor gene and
   protein expression in the human hepatocyte cell line OUMS-29
SO JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
LA English
DT Article
DE atherosclerosis; metabolic syndrome; oxidative stress; pigment
   epithelium-derived factor
ID OXYGEN SPECIES GENERATION; ENDOTHELIAL-CELLS; METABOLIC SYNDROME; NADPH
   OXIDASE; FACTOR PEDF; GROWTH; ANGIOGENESIS; MECHANISM; VEGF
AB Pigment epithelium-derived factor (PEDF) may have a protective role in atherosclerosis and is associated with the presence of components of the metabolic syndrome. Since oxidative stress has been postulated to play an important role in the pathogenesis of vascular injury in the metabolic syndrome, this study investigated the effects of hydrogen peroxide (H2O2) on PEDF in the immortalized human hepatocyte cell line OUMS-29. PEDF gene expression was measured using quantitative real-time reverse transcription-polymerase chain reaction and PEDF protein expression was analysed by Western blot. H2O2 upregulated PEDF mRNA levels and increased PEDF protein production in OUMS-29 cells in time- and dose-dependent manners. The anti-oxidant Nacetylcysteine significantly blocked H2O2-induced PEDF overexpression in OUMS-29 cells. These results suggest that hepatic PEDF levels may be elevated to counteract the effects of oxidative stress. H2O2-induced PEDF overproduction in the liver may act as a negative feedback system against vascular damage in the metabolic syndrome.
C1 Kurume Univ Sch Med, Div Cardiovasc Med, Dept Med, Kurume, Fukuoka 8300011, Japan.
   Kurume Univ Sch Med, Dept Internal Med, Kurume, Fukuoka 8300011, Japan.
   Kurume Univ Sch Med, Radioisotope Inst Basic & Clin Med, Kurume, Fukuoka 8300011, Japan.
C3 Kurume University; Kurume University; Kurume University
RP Yamagishi, S (corresponding author), Kurume Univ Sch Med, Div Cardiovasc Med, Dept Med, 67 Asahi Machi, Kurume, Fukuoka 8300011, Japan.
EM shoichi@med.kurume-u.ac.jp
OI Matsui, Takanori/0000-0001-9506-7571
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NR 21
TC 14
Z9 14
U1 0
U2 0
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0300-0605
EI 1473-2300
J9 J INT MED RES
JI J. Int. Med. Res.
PD MAY-JUN
PY 2007
VL 35
IS 3
BP 427
EP 432
DI 10.1177/147323000703500319
PG 6
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA 180RZ
UT WOS:000247384700019
PM 17593873
OA Bronze
DA 2025-06-11
ER

PT J
AU Gothefors, D
   Adolfsson, R
   Attvall, S
   Erlinge, D
   Jarbin, H
   Lindström, K
   von Hausswolff-Juhlin, YL
   Morgell, R
   Toft, E
   Ösby, U
AF Gothefors, Dan
   Adolfsson, Rolf
   Attvall, Stig
   Erlinge, David
   Jarbin, Hakan
   Lindstrom, Kjell
   von Hausswolff-Juhlin, Yvonne Linne
   Morgell, Roland
   Toft, Eva
   Osby, Urban
TI Swedish clinical guidelines-Prevention and management of metabolic risk
   in patients with severe psychiatric disorders
SO NORDIC JOURNAL OF PSYCHIATRY
LA English
DT Article
DE Severe mental illness; Severe mental disorder; Schizophrenia; Bipolar
   disorder; Physical health; Weight gain; Diabetes; Cardiovascular
   disease; Guidelines; Clinical practice guidelines
ID INDUCED WEIGHT-GAIN; CHRONIC MEDICAL ILLNESSES; EARLY-ONSET
   SCHIZOPHRENIA; DOUBLE-BLIND; ATYPICAL ANTIPSYCHOTICS; 2ND-GENERATION
   ANTIPSYCHOTICS; CARDIOMETABOLIC RISK; INSULIN-RESISTANCE;
   GLUCOSE-TOLERANCE; BIPOLAR DISORDER
AB Individuals with severe psychiatric disorders are more likely than the population at large to develop metabolic derangements such as overweight and diabetes. Cardiovascular disease is also more frequently seen in this group. Contributing factors may include inappropriate diet or lack of physical activity, but antipsychotic medication may also play a role. Seven Swedish specialist medical societies have collaborated in formulating a set of concise clinically applicable guidelines-reproduced here in modified form-for the prevention and management of metabolic risk in this patient group. The importance of implementation is emphasized.
C1 [Adolfsson, Rolf] Umea Univ, Swedish Psychiat Association, Dept Clin Sci, S-90187 Umea, Sweden.
   [Attvall, Stig] Sahlgrens Univ Hosp, Swedish Assoc Diabetol, Gothenburg, Sweden.
   [Erlinge, David] Univ Lund Hosp, Swedish Soc Cardiol, Dept Cardiol, Lund, Sweden.
   [von Hausswolff-Juhlin, Yvonne Linne] Swedish Assoc Study Obes, Stockholm Ctr Eating Disorders, Stockholm, Sweden.
C3 Umea University; Sahlgrenska University Hospital; Lund University; Skane
   University Hospital
EM dan.gothefors@dll.se
OI Attvall, Stig/0000-0003-2163-2341; Toft, Eva/0000-0003-1087-445X;
   Adolfsson, Rolf/0000-0001-9785-8473
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   LAKEMEDELSBOKEN 2007
NR 82
TC 33
Z9 36
U1 0
U2 6
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0803-9488
EI 1502-4725
J9 NORD J PSYCHIAT
JI Nord. J. Psychiatr.
PD OCT
PY 2010
VL 64
IS 5
BP 294
EP 302
DI 10.3109/08039488.2010.500397
PG 9
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 662VW
UT WOS:000282843400002
PM 20662682
OA Bronze
DA 2025-06-11
ER

PT J
AU González-Domínguez, A
   Belmonte, T
   González-Domínguez, R
AF Gonzalez-Dominguez, Alvaro
   Belmonte, Thalia
   Gonzalez-Dominguez, Raul
TI Childhood obesity, metabolic syndrome, and oxidative stress: microRNAs
   go on stage
SO REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
LA English
DT Article
DE Childhood obesity; Oxidative stress; miRNA; Metabolic syndrome; Iron
   metabolism
ID ENDOTHELIAL FUNCTION; INSULIN-RESISTANCE; MIRNA SIGNATURES; HEME
   OXYGENASE-1; BINDING PROTEIN; MESSENGER-RNAS; UP-REGULATION;
   WEIGHT-LOSS; INFLAMMATION; EXPRESSION
AB The incidence of childhood obesity and metabolic syndrome has grown notably in the last years, becoming major public health burdens in developed countries. Nowadays, oxidative stress is well-recognized to be closely associated with the onset and progression of several obesity-related complications within the framework of a complex crosstalk involving other intertwined pathogenic events, such as inflammation, insulin disturbances, and dyslipidemia. Thus, understanding the molecular basis behind these oxidative dysregulations could provide new approaches for the diagnosis, prevention, and treatment of childhood obesity and associated disorders. In this respect, the transcriptomic characterization of miRNAs bares great potential because of their involvement in post-transcriptional modulation of genetic expression. Herein, we provide a comprehensive literature revision gathering state-of-the-art research into the association between childhood obesity, metabolic syndrome, and miRNAs. We put special emphasis on the potential role of miRNAs in modulating obesity-related pathogenic events, with particular focus on oxidative stress.
C1 [Gonzalez-Dominguez, Alvaro; Gonzalez-Dominguez, Raul] Univ Cadiz, Hosp Univ Puerta Mar, Inst Invest & Innovac Biomed Cadiz INiBICA, Cadiz 11009, Spain.
   [Belmonte, Thalia] Univ Hosp Arnau Vilanova & St Maria, Translat Res Resp Med, IRBLleida, Lleida, Spain.
   [Belmonte, Thalia] Inst Hlth Carlos III, CIBER Resp Dis CIBERES, Madrid, Spain.
C3 Universidad de Cadiz; Hospital Universitario Puerta del Mar; CIBER -
   Centro de Investigacion Biomedica en Red; CIBERES
RP González-Domínguez, A (corresponding author), Univ Cadiz, Hosp Univ Puerta Mar, Inst Invest & Innovac Biomed Cadiz INiBICA, Cadiz 11009, Spain.
EM alvaro.gonzalez@inibica.es
RI González Domínguez, Álvaro/HJH-1098-2023; Gonzalez-Dominguez,
   Raul/E-5125-2016
OI Gonzalez-Dominguez, Raul/0000-0002-7640-8833; Belmonte,
   Thalia/0000-0003-1241-6073; Gonzalez Dominguez,
   Alvaro/0000-0002-7080-4245
FU Universidad de Cadiz/CBUA
FX Funding for open access publishing: Universidad de Cadiz/CBUA
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NR 199
TC 10
Z9 10
U1 0
U2 13
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1389-9155
EI 1573-2606
J9 REV ENDOCR METAB DIS
JI Rev. Endocr. Metab. Disord.
PD DEC
PY 2023
VL 24
IS 6
BP 1147
EP 1164
DI 10.1007/s11154-023-09834-0
EA SEP 2023
PG 18
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA AZ4X6
UT WOS:001059630600001
PM 37672200
OA hybrid
DA 2025-06-11
ER

PT J
AU Hohor, S
   Mandanach, C
   Maftei, A
   Zugravu, CA
   Otelea, MR
AF Hohor, Sorina
   Mandanach, Cristina
   Maftei, Andreea
   Zugravu, Corina Aurelia
   Otelea, Marina Ruxandra
TI Impaired Melatonin Secretion, Oxidative Stress and Metabolic Syndrome in
   Night Shift Work
SO ANTIOXIDANTS
LA English
DT Review
DE metabolic syndrome; night shift; melatonin; oxidative stress;
   chronodisruption
ID NITRIC-OXIDE PRODUCTION; CLOCK GENE-EXPRESSION; BLOOD-PRESSURE;
   SIGNALING PATHWAY; ADIPOSE-TISSUE; DOUBLE-BLIND; MITOCHONDRIAL DYNAMICS;
   CIRCADIAN-RHYTHMS; REACTIVE OXYGEN; BRAIN-INJURY
AB Metabolic syndrome has been associated in many studies with working in shifts. Even if the mechanistic details are not fully understood, forced sleep deprivation and exposure to light, as happens during night shifts, or irregular schedules with late or very early onset of the working program, lead to a sleep-wake rhythm misalignment, metabolic dysregulation and oxidative stress. The cyclic melatonin secretion is regulated by the hypothalamic suprachiasmatic nuclei and light exposure. At a central level, melatonin promotes sleep and inhibits wake-signals. Beside this role, melatonin acts as an antioxidant and influences the functionality of the cardiovascular system and of different metabolic processes. This review presents data about the influence of night shifts on melatonin secretion and oxidative stress. Assembling data from epidemiological, experimental and clinical studies contributes to a better understanding of the pathological links between chronodisruption and the metabolic syndrome related to working in shifts.
C1 [Hohor, Sorina; Mandanach, Cristina; Maftei, Andreea] Carol Davila Univ Med & Pharm, Doctoral Sch, 37 Dionisie Lupu St,Sect 2, Bucharest 020021, Romania.
   [Maftei, Andreea] Dr Carol Davila Cent Mil Emergency Univ Hosp, 134 Calea Plevnei,Sect 1, Bucharest 010242, Romania.
   [Zugravu, Corina Aurelia] Carol Davila Univ Med & Pharm, Dept Hyg & Ecol, 37 Dionisie Lupu St,Sect 2, Bucharest 020021, Romania.
   [Otelea, Marina Ruxandra] Carol Davila Univ Med & Pharm, Clin Dept 5, 37 Dionisie Lupu St,Sect 2, Bucharest 020021, Romania.
C3 Carol Davila University of Medicine & Pharmacy; Carol Davila University
   of Medicine & Pharmacy; Carol Davila University of Medicine & Pharmacy
RP Otelea, MR (corresponding author), Carol Davila Univ Med & Pharm, Clin Dept 5, 37 Dionisie Lupu St,Sect 2, Bucharest 020021, Romania.
EM sorina.giurgiulescu@drd.umfcd.ro; cristina.paraschiv@drd.umfcd.ro;
   andreea.mutu@drd.umfcd.ro; corina.zugravu@umfcd.ro;
   marina.otelea@umfcd.ro
RI Hohor, Sorina/GZG-3229-2022; Otelea, Marina/N-4200-2016; Paraschiv
   Mandanach, Cristina/HHC-5381-2022; Zugravu, Corina/AAX-3256-2020
OI Hohor, Sorina/0009-0003-8253-2480; Otelea, Marina
   Ruxandra/0000-0002-0829-0562; Zugravu, Corina/0000-0002-3563-6987
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NR 168
TC 17
Z9 17
U1 0
U2 18
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD APR
PY 2023
VL 12
IS 4
AR 959
DI 10.3390/antiox12040959
PG 19
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA E7FQ1
UT WOS:000977162500001
PM 37107334
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Colas, R
   Sassolas, A
   Guichardant, M
   Cugnet-Anceau, C
   Moret, M
   Moulin, P
   Lagarde, M
   Calzada, C
AF Colas, R.
   Sassolas, A.
   Guichardant, M.
   Cugnet-Anceau, C.
   Moret, M.
   Moulin, P.
   Lagarde, M.
   Calzada, C.
TI LDL from obese patients with the metabolic syndrome show increased lipid
   peroxidation and activate platelets
SO DIABETOLOGIA
LA English
DT Article
DE Fatty acids; LDL; Lipid peroxidation; Metabolic syndrome; Obesity;
   Oxidised LDL; Platelets; Type 2 diabetes
ID LOW-DENSITY-LIPOPROTEIN; C-REACTIVE PROTEIN; OXIDATIVE STRESS;
   PLASMALOGEN PHOSPHOLIPIDS; CARDIOVASCULAR-DISEASE; DIABETIC-PATIENTS;
   AGGREGATION; RISK; PARTICLES; A(2)
AB This study assessed oxidative stress in LDL from obese patients with the metabolic syndrome and compared it with that in LDL from type 2 diabetic patients or control volunteers. It also determined the effect on platelets of LDL from the three groups.
   The profiles of lipids, fatty acids and fatty acid oxidation products were determined in LDL isolated from plasma of patients with the metabolic syndrome, patients with type 2 diabetes and volunteers (n = 10 per group). The effects of LDL from the participant groups on the platelet arachidonic acid signalling cascade and aggregation were investigated.
   Compared with LDL from control volunteers, LDL from obese metabolic syndrome and type 2 diabetic patients had lower cholesteryl ester, higher triacylglycerol and lower ethanolamine plasmalogen levels. Proportions of linoleic acid were decreased in phosphatidylcholine and cholesteryl esters in LDL from both patient groups. Among the markers of lipid peroxidation, oxidation products of linoleic acid (hydroxy-octadecadienoic acids) and malondialdehyde were increased by 59% and twofold, respectively in LDL from metabolic syndrome and type 2 diabetic patients. LDL from metabolic syndrome and type 2 diabetic patients were equally potent in activating the platelet arachidonic acid signalling cascade through increased phosphorylation of p38 mitogen-activated protein kinase and cytosolic phospholipase A(2), and through increased thromboxane B-2 formation. LDL from patients with the metabolic syndrome and type 2 diabetes potentiated platelet aggregation by threefold and 3.5-fold respectively, whereas control LDL had no activating effects on platelets.
   The metabolic syndrome in obese patients, without or with diabetes, is associated with increased oxidative stress in LDL, which triggers platelet activation.
   ClinicalTrials.gov NCT00932087
   The study was funded by INSERM (Institut National de la Sant, et de la Recherche M,dicale) and ANR (Agence Nationale de la Recherche).
C1 [Colas, R.; Sassolas, A.; Guichardant, M.; Moulin, P.; Lagarde, M.; Calzada, C.] Univ Lyon, INSERM, UMR 1060, INSA Lyon,IMBL, F-69621 Villeurbanne, France.
   [Sassolas, A.; Cugnet-Anceau, C.; Moret, M.; Moulin, P.] Hosp Civils Lyon, Bron, France.
C3 Institut National de la Sante et de la Recherche Medicale (Inserm);
   Institut National des Sciences Appliquees de Lyon - INSA Lyon;
   Universite Claude Bernard Lyon 1; CHU Lyon
RP Calzada, C (corresponding author), Univ Lyon, INSERM, UMR 1060, INSA Lyon,IMBL, Bat Louis Pasteur,20 Av Albert Einstein, F-69621 Villeurbanne, France.
EM Catherine.Calzada@insa-lyon.fr
OI Calzada, Catherine/0000-0001-8858-6752
FU INSERM; ANR [ANR-05-COD-D019-01]; French Ministry of Education and
   Research; CNRS
FX This study was supported by INSERM and ANR grant (ANR-05-COD-D019-01).
   R. Colas was funded by the French Ministry of Education and Research. C.
   Calzada is supported by the CNRS. The authors gratefully thank Z. Mallat
   and Aterovax (Paris, France) for the analysis of sPLA<INF>2</INF>
   activity. The authors also thank all participants, the nursing staff at
   Hospices Civils de Lyon for expert blood drawing assistance and M.
   Broyer for particle size data analysis.
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NR 47
TC 64
Z9 70
U1 0
U2 10
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0012-186X
EI 1432-0428
J9 DIABETOLOGIA
JI Diabetologia
PD NOV
PY 2011
VL 54
IS 11
BP 2931
EP 2940
DI 10.1007/s00125-011-2272-8
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 830TJ
UT WOS:000295679800021
PM 21847583
OA Bronze, Green Accepted
DA 2025-06-11
ER

PT J
AU Olive, LS
   Telford, RM
   Byrne, DG
   Abhayaratna, WP
   Telford, RD
AF Olive, Lisa S.
   Telford, Rohan M.
   Byrne, D. G.
   Abhayaratna, Walter P.
   Telford, Richard D.
TI Symptoms of Stress and Depression Effect Percentage of Body Fat and
   Insulin Resistance in Healthy Youth: LOOK Longitudinal Study
SO HEALTH PSYCHOLOGY
LA English
DT Article
DE insulin resistance; body composition; depression; stress-psychological;
   diabetes mellitus Type II
ID TYPE-2 DIABETES-MELLITUS; HOMEOSTATIC MODEL ASSESSMENT; CARDIOVASCULAR
   RISK-FACTORS; METABOLIC SYNDROME; PHYSICAL-ACTIVITY; LIFE-SPAN; HOMA-IR;
   CHILDREN; OBESITY; CHILDHOOD
AB Objective: This study examined the longitudinal and cross-sectional effects of both psychosocial stress and depressive symptoms on insulin resistance and percentage body fat in a cohort of healthy Australian children, following them from childhood into adolescence. Method: Participants were 791 healthy, initially Grade 2 children (7-8 years; 394 girls), selected from the general community. Psychosocial stress was assessed using the Children's Stress Questionnaire, while depressive symptoms were assessed using the Children's Depression Inventory. Fasting blood samples for serum insulin and plasma glucose were collected to calculate the homeostasis model assessment-insulin resistance (HOMA-IR). Other measurements were height, weight, percentage body fat (dual energy x-ray absorptiometry), physical activity (pedometers), and pubertal maturation (Tanner score). Results: Boys who reported more symptoms of depression had higher insulin resistance, irrespective of adiposity (p=.016); and longitudinally, we found a trend for boys who developed more depressive symptoms to develop higher insulin resistance (p=.073). These findings did not extend to girls. Furthermore, boys and girls with higher depressive symptoms had a higher percentage of body fat (p=.011 and .020, respectively); and longitudinally, boys whose depressive symptoms increased became fatter (p=.046). Conclusion: Our data provide evidence that early symptoms of depression increase insulin resistance, independent of adiposity. Our evidence that early symptoms of depression may lead to overweight, and obesity provides further reason to suggest that early attention to children with depression, even in preclinical stages, may reduce risk of chronic disease in later life.
C1 [Olive, Lisa S.; Byrne, D. G.; Abhayaratna, Walter P.] Australian Natl Univ, Sch Med, Canberra, ACT, Australia.
   [Olive, Lisa S.] Deakin Univ, Sch Psychol, Melbourne Burwood Campus,221 Burwood Highway, Burwood, Vic 3125, Australia.
   [Telford, Rohan M.] Univ Canberra, Ctr Res & Act Publ Hlth, Canberra, ACT, Australia.
   [Telford, Rohan M.; Telford, Richard D.] Univ Canberra, Res Inst Sport & Exercise, Canberra, ACT, Australia.
   [Abhayaratna, Walter P.] Canberra Hosp, Clin Trials Unit, Acad Unit Internal Med, Garran, ACT, Australia.
C3 Australian National University; Deakin University; University of
   Canberra; University of Canberra; Australian National University;
   Canberra Hospital
RP Olive, LS (corresponding author), Deakin Univ, Sch Psychol, Melbourne Burwood Campus,221 Burwood Highway, Burwood, Vic 3125, Australia.
EM lisa.olive@deakin.edu.au
RI Abhayaratna, Walter/KJK-9982-2024
OI Telford, Richard/0000-0003-4485-9362; Telford,
   Rohan/0000-0002-1723-2559; Olive, Lisa/0000-0003-4643-8561; Abhayaratna,
   Walter/0000-0002-4908-0641
FU National Heart Foundation of Australia/National Health and Medical
   Research Council Scholarship [GNT1056551]; Australian Research Council
   (Linkage) Grant; Commonwealth Education Trust (New Zealand House,
   London, U.K.); Canberra Hospital Salaried Staff Specialists Private
   Practice Fund (Canberra, Australia)
FX We extend our thanks to the children of the LOOK study for their efforts
   and ongoing participation. We would also like to acknowledge the
   Australian Capital Territory (ACT) Department of Education and Training,
   school principals, teachers, office staff, and parents for their willing
   cooperation; Professor Ross Cunningham for his statistical consultation;
   Paul Waring from the Australian National University and Professor Julia
   Potter, Associate Professor Peter Hickman, Emma Southcott, and Jennifer
   Kerrigan from ACT Pathology at the Canberra Hospital for the on-site
   preparation of the blood samples, transport, and supervision of the
   assays at the hospital pathology laboratories. Support for this research
   was provided via a cofunded National Heart Foundation of
   Australia/National Health and Medical Research Council Scholarship
   (GNT1056551) awarded to Lisa S. Olive; an Australian Research Council
   (Linkage) Grant to D. G. Byrne; the Commonwealth Education Trust (New
   Zealand House, London, U.K.; http://www.commonwealth.org.uk/) awarded to
   Rohan M. Telford; and the Canberra Hospital Salaried Staff Specialists
   Private Practice Fund (Canberra, Australia), awarded to Walter P.
   Abhayaratna. The funders had no role in study design, data collection
   and analysis, decision to publish, or preparation of the manuscript.
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NR 80
TC 16
Z9 16
U1 0
U2 23
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 0278-6133
EI 1930-7810
J9 HEALTH PSYCHOL
JI Health Psychol.
PD AUG
PY 2017
VL 36
IS 8
BP 749
EP 759
DI 10.1037/hea0000496
PG 11
WC Psychology, Clinical; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology
GA FB4IW
UT WOS:000406106200004
PM 28541073
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Buendia, ASA
   Rojas, JGJ
   García-Arroyo, F
   Trejo, OEA
   Sánchez-Muñoz, F
   Argüello-García, R
   ánchez-Lozada, LG
   Bojalil, R
   Osorio-Alonso, H
AF Buendia, Abraham Said Arellano
   Rojas, Juan Gabriel Juarez
   Garcia-Arroyo, Fernando
   Trejo, Omar Emiliano Aparicio
   Sanchez-Munoz, Fausto
   Arguello-Garcia, Raul
   Sanchez-Lozada, Laura Gabriela
   Bojalil, Rafael
   Osorio-Alonso, Horacio
TI Antioxidant and anti-inflammatory effects of allicin in the kidney of an
   experimental model of metabolic syndrome
SO PEERJ
LA English
DT Article
DE Metabolic syndrome; Allicin; Chronic kidney disease; Inflammation;
   Oxidative stress; Hypertension
ID MITOCHONDRIAL BIOENERGETICS; OXIDATIVE STRESS; IMPAIRMENT; FIBROSIS
AB Background: Recent studies have suggested that metabolic syndrome (MS) encompasses a group of risk factors for developing chronic kidney disease (CKD). This work aimed to evaluate the antioxidant and anti-inflammatory effects of allicin in the kidney from an experimental model of MS.Methods: Male Wistar rats (220-250 g) were used, and three experimental groups (n = 6) were formed: control (C), metabolic syndrome (MS), and MS treated with allicin (16 mg/Kg/day, gastric gavage) (MS+A). MS was considered when an increase of 20% in at least three parameters (body weight, systolic blood pressure (SBP), fasting blood glucose (FBG), or dyslipidemia) was observed compared to the C group. After the MS diagnosis, allicin was administered for 30 days.Results: Before the treatment with allicin, the MS group showed more significant body weight gain, increased SBP, and FBG, glucose intolerance, and dyslipidemia. In addition, increased markers of kidney damage in urine and blood. Moreover, the MS increased oxidative stress and inflammation in the kidney compared to group C. The allicin treatment prevented further weight gain, reduced SBP, FBG, glucose intolerance, and dyslipidemia. Also, markers of kidney damage in urine and blood were decreased. Further, the oxidative stress and inflammation were decreased in the renal cortex of the MS+A compared to the MS group.Conclusion: Allicin exerts its beneficial effects on the metabolic syndrome by considerably reducing systemic and renal inflammation as well as the oxidative stress. These effects were mediated through the Nrf2 pathway. The results suggest allicin may be a therapeutic alternative for treating kidney injury induced by the metabolic syndrome risk factors.
C1 [Buendia, Abraham Said Arellano] Univ Autonoma Metropolitana, Ciencias Biol & Salud, Mexico City, Xochimilco, Mexico.
   [Buendia, Abraham Said Arellano; Garcia-Arroyo, Fernando; Trejo, Omar Emiliano Aparicio; Sanchez-Lozada, Laura Gabriela; Osorio-Alonso, Horacio] Inst Nacl Cardiol Ignacio Chavez, Fisiopatol Cardiorenal, Mexico City, Tlalpan, Mexico.
   [Rojas, Juan Gabriel Juarez] Inst Nacl Cardiol Ignacio Chavez, Endocrinol, Mexico City, Tlalpan, Mexico.
   [Sanchez-Munoz, Fausto] Inst Nacl Cardiol Ignacio Chavez, Inmunol, Mexico City, Tlalpan, Mexico.
   [Arguello-Garcia, Raul] Ctr Invest & Estudios Avanzados IPN, Genet & Biol Mol, Dept Genet & Biol Mo, Mexico City, Gustavo A Mader, Mexico.
   [Bojalil, Rafael] Univ Autonoma Metropolitana, Atenc Salud, Mexico City, Xochimilco, Mexico.
C3 Universidad Autonoma Metropolitana - Mexico; National Institute of
   Cardiology - Mexico; National Institute of Cardiology - Mexico; National
   Institute of Cardiology - Mexico; CINVESTAV - Centro de Investigacion y
   de Estudios Avanzados del Instituto Politecnico Nacional; Universidad
   Autonoma Metropolitana - Mexico
RP Osorio-Alonso, H (corresponding author), Inst Nacl Cardiol Ignacio Chavez, Fisiopatol Cardiorenal, Mexico City, Tlalpan, Mexico.; Bojalil, R (corresponding author), Univ Autonoma Metropolitana, Atenc Salud, Mexico City, Xochimilco, Mexico.
EM rafaelbojalil@gmail.com; horace_33@yahoo.com.mx
RI Juárez-Rojas, Juan/AAM-9486-2020; Alonso, Horacio/T-3946-2019;
   Sanchez-Muñoz, Fausto/KIE-6221-2024; Aparicio-Trejo, Omar/AAQ-3900-2021
OI SANCHEZ-MUNOZ, FAUSTO/0000-0001-6556-1632; Juarez-Rojas, Juan
   Gabriel/0000-0001-8864-2304; Osorio Alonso, Horacio/0000-0002-9238-4202
FU Instituto Nacional de Cardiologia Ignacio Chavez
FX The financing for this research as well as the publishing in open access
   were covered by the Instituto Nacional de Cardiologia Ignacio Chavez.
   The funders had no role in study design, data collection and analysis,
   decision to publish, or preparation of the manuscript.
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NR 56
TC 6
Z9 5
U1 3
U2 8
PU PEERJ INC
PI LONDON
PA 341-345 OLD ST, THIRD FLR, LONDON, EC1V 9LL, ENGLAND
SN 2167-8359
J9 PEERJ
JI PeerJ
PD SEP 27
PY 2023
VL 11
AR e16132
DI 10.7717/peerj.16132
PG 23
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA U4LM1
UT WOS:001084529600005
PM 37786577
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Suarez, EC
   Boyle, SH
   Lewis, JG
   Hall, RP
   Young, KH
AF Suarez, Edward C.
   Boyle, Stephen H.
   Lewis, James G.
   Hall, Russell P.
   Young, Kenneth H.
TI Increases in stimulated secretion of proinfiammatory cytokines by blood
   monocytes following arousal of negative affect: The role of insulin
   resistance as moderator
SO BRAIN BEHAVIOR AND IMMUNITY
LA English
DT Article
DE psychological stress; negative affect; insulin resistance; cytokines;
   monocytes; homeostatic model assessment; men
ID HOMEOSTASIS MODEL ASSESSMENT; FACTOR-KAPPA-B; CARDIOVASCULAR-DISEASE;
   METABOLIC SYNDROME; TNF-ALPHA; MECHANISMS; STRESS; INFLAMMATION;
   ASSOCIATION; EXPRESSION
AB We examined the effect of negative affect on changes in stimulated secretion of cytokines by blood monocytes and determined whether insulin resistance (IR), as indexed by the Homeostasis Model Assessment (HOMA), moderated these associations in 58 healthy men (aged 18-65 years). Blood samples and ratings of negative affect were collected at rest and 15 min following subjects' participation in the Anger Recall Interview (ARI). Assessment of lipopolysaccharide (LPS)-stimulated secretion of IL-1 beta, IL-6, and TNF-alpha was accomplished by ELISA of supernatant. Regression models controlling for age, body mass index, and race/ethnicity revealed that higher HOMA-IR values were associated with larger stress-induced increases in IL-1 beta and TNF-alpha (p < .05). Furthermore, arousal of negative affect during the ARI was differentially associated with stress-induced changes in stimulated secretion of TNF-alpha and IL-6 as a function of HOMA-IR (p < .05). Increases in stimulated cytokine secretion were associated with arousal of negative affect, but only among men with higher HOMA-IR values. Among men with lower HOMA-IR values, arousal of negative affect was associated with diminished cytokine secretion. Collectively, these data suggest that the HOMA-IR moderates the impact that arousal of negative affect has on the ability of blood monocytes to secrete inflammatory cytokines in response to LPS. Stress-induced increases in cytokine secretion among high HOMA-IR men are consistent with the role of inflammation in cardiovascular disease, hypertension, type 2 diabetes as well as the metabolic syndrome and underscore the relevance of negative affect in the etiology of these inflammatory conditions. (c) 2005 Elsevier Inc. All rights reserved.
C1 Duke Univ, Med Ctr, Dept Psychiat & Behav Sci, Durham, NC 27708 USA.
   Duke Univ, Med Ctr, Dept Pathol, Durham, NC USA.
   Duke Univ, Med Ctr, Dept Dermatol, Durham, NC USA.
C3 Duke University; Duke University; Duke University
RP Suarez, EC (corresponding author), Duke Univ, Med Ctr, Dept Psychiat & Behav Sci, Durham, NC 27708 USA.
EM suare001@mc.duke.edu
RI Suarez, Edward/HPE-3092-2023
OI Suarez, Edward/0000-0003-3069-5846
FU NHLBI NIH HHS [P01 HL036587] Funding Source: Medline
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NR 35
TC 40
Z9 45
U1 0
U2 4
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0889-1591
EI 1090-2139
J9 BRAIN BEHAV IMMUN
JI Brain Behav. Immun.
PD JUL
PY 2006
VL 20
IS 4
BP 331
EP 338
DI 10.1016/j.bbi.2005.09.005
PG 8
WC Immunology; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Neurosciences & Neurology; Psychiatry
GA 055UM
UT WOS:000238476000005
PM 16288846
DA 2025-06-11
ER

PT J
AU Safiedeen, Z
   Andriantsitohaina, R
   Martinez, MC
AF Safiedeen, Zainab
   Andriantsitohaina, Ramaroson
   Martinez, M. Carmen
TI Dialogue between endoplasmic reticulum and mitochondria as a key actor
   of vascular dysfunction associated to metabolic disorders
SO INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
LA English
DT Article
DE Endothelium; Metabolic syndrome; Endoplasmic reticulum stress;
   Mitochondria; Mitochondria-associated membranes
ID ENDOTHELIAL DYSFUNCTION; INSULIN-RESISTANCE; MITOFUSIN 2; ER STRESS;
   CELLS; ATHEROSCLEROSIS; CONTRIBUTES; EXPRESSION; APOPTOSIS; DISEASE
AB Metabolic syndrome due to its association with increased risk of cardiovascular diseases and cardiac mortality, comprises a cluster of metabolic abnormalities such as central obesity, hyperglycemia, dyslipidemia, and hypertension. Recent studies have shown that metabolic syndrome patients exhibit impaired nitric oxide-mediated vasodilatation leading to endothelial dysfunction in addition to insulin resistance. Interestingly, development and maintenance of the unfolded protein response of the endoplasmic reticulum stress revealed a surprisingly direct link with metabolic syndrome and endothelial dysfunction. On the other hand, in metabolic disorders, interaction between endoplasmic reticulum and mitochondria is mandatory for the generation of mitochondrial oxidative stress and perturbation of mitochondrial function accounting, at least in part, for vascular dysfunction. Herein, we review the impact of the dialogue between endoplasmic reticulum and mitochondria in modulating the cellular signals governing vascular alterations associated to metabolic disorders. (C) 2016 Elsevier Ltd. All rights reserved.
C1 [Safiedeen, Zainab; Andriantsitohaina, Ramaroson; Martinez, M. Carmen] Univ Angers, INSERM UMR1063, Angers, France.
   [Safiedeen, Zainab] Lebanese Univ, Lab Stem Cells, ER045, DSST,PRASE, Beirut, Lebanon.
C3 Institut National de la Sante et de la Recherche Medicale (Inserm);
   Universite d'Angers; Lebanese University
RP Andriantsitohaina, R (corresponding author), Univ Angers, INSERM UMR1063, Angers, France.; Andriantsitohaina, R (corresponding author), INSERM UMR Stress Oxydant & Pathol Metab 1063, Inst Biol Sante, 4 Rue Larrey, F-49933 Angers, France.
EM ramaroson.andriantsitohaina@univ-angers.fr
RI ANDRIANTSITOHAINA, Ramaroson/H-5286-2018; Martinez, Maria
   Carmen/LSJ-1622-2024
OI andriantsitohaina, ramaroson/0000-0002-4770-3585; Martinez, M
   Carmen/0000-0003-3897-7397
FU INSERM; Universite d'Angers; "Association de Specialisation et
   d'Orientation Scientifique" from Lebanon
FX This work was partially supported by INSERM and Universite d'Angers. ZS
   is recipient of a doctoral fellowship from the "Association de
   Specialisation et d'Orientation Scientifique" from Lebanon.
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U1 1
U2 28
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 1357-2725
EI 1878-5875
J9 INT J BIOCHEM CELL B
JI Int. J. Biochem. Cell Biol.
PD AUG
PY 2016
VL 77
BP 10
EP 14
DI 10.1016/j.biocel.2016.05.011
PN A
PG 5
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA DT7EL
UT WOS:000381649800002
PM 27208732
DA 2025-06-11
ER

PT J
AU Sharebiani, H
   Mokaram, M
   Mirghani, M
   Fazeli, B
   Stanek, A
AF Sharebiani, Hiva
   Mokaram, Mina
   Mirghani, Melika
   Fazeli, Bahare
   Stanek, Agata
TI The Effects of Antioxidant Supplementation on the Pathologic Mechanisms
   of Metabolic Syndrome and Cardiovascular Disease Development
SO NUTRIENTS
LA English
DT Review
DE metabolic syndrome; obesity; hypertension; oxidative stress; antioxidant
   supplementation
ID OXIDATIVE STRESS; INSULIN-RESISTANCE; BLOOD-PRESSURE; VITAMIN-E;
   HYPERTENSION; ZINC; INFLAMMATION; ACTIVATION; GENERATION; PARAMETERS
AB In people with obesity, diabetes, and hypertension, lipid and glucose metabolism and oxidative stress generation interact. This condition, known as a "metabolic syndrome" (MetS), presents a global challenge and appears to be the underlying mechanism for the development of cardiovascular diseases (CVDs). This review is designed based on evidence indicating the pathogenic mechanisms of MetS. In detail, we will look at the mechanisms of oxidative stress induction in MetS, the effects of elevated oxidative stress levels on the condition's pathophysiology, and matters related to endothelial function. According to different components of the MetS pathophysiological network, the effects of antioxidants and endothelial dysfunction are reviewed. After considering the strategic role of oxidative stress in the pathophysiology of MetS and its associated CVDs, oxidative stress management by antioxidant supplementation seems an appropriate therapeutic approach.
C1 [Sharebiani, Hiva; Mirghani, Melika; Fazeli, Bahare; Stanek, Agata] VAS European Independent Fdn Angiol Vasc Med, Via GB Grassi 74, I-20157 Milan, Italy.
   [Sharebiani, Hiva; Mokaram, Mina; Mirghani, Melika; Fazeli, Bahare] Buergers Dis NGO, Support Assoc Patients Buergers Dis, Mashhad 9183785195, Iran.
   [Mokaram, Mina] Tarbiat Modares Univ, Fac Biol Sci, Dept Biochem, Tehran 14115-175, Iran.
   [Stanek, Agata] Med Univ Silesia, Fac Med Sci Zabrze, Dept Internal Med Angiol & Phys Med, Batorego 15 St, PL-41902 Bytom, Poland.
C3 Tarbiat Modares University; Medical University of Silesia
RP Stanek, A (corresponding author), VAS European Independent Fdn Angiol Vasc Med, Via GB Grassi 74, I-20157 Milan, Italy.; Stanek, A (corresponding author), Med Univ Silesia, Fac Med Sci Zabrze, Dept Internal Med Angiol & Phys Med, Batorego 15 St, PL-41902 Bytom, Poland.
EM hivasharebiani95@gmail.com; minaamokaram@gmail.com;
   mirghanimel@gmail.com; bahar.fazeli@gmail.com; astanek@tlen.pl
RI Stanek, Agata/N-8179-2017
OI Mokaram Doost Delkhah, Mina/0009-0000-4835-3751; Stanek,
   Agata/0000-0001-6939-9898
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NR 126
TC 10
Z9 10
U1 2
U2 8
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JUN
PY 2024
VL 16
IS 11
AR 1641
DI 10.3390/nu16111641
PG 27
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA UA2C5
UT WOS:001245267100001
PM 38892574
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Kahl, KG
   Kerling, A
   Tegtbur, U
   Gützlaff, E
   Herrmann, J
   Borchert, L
   Ates, Z
   Westhoff-Bleck, M
   Hueper, K
   Hartung, D
AF Kahl, K. G.
   Kerling, A.
   Tegtbur, U.
   Guetzlaff, E.
   Herrmann, J.
   Borchert, L.
   Ates, Zeynep
   Westhoff-Bleck, M.
   Hueper, K.
   Hartung, D.
TI Effects of additional exercise training on epicardial, intra-abdominal
   and subcutaneous adipose tissue in major depressive disorder: A
   randomized pilot study
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Intra-abdominal adipose tissue; Epicardial adipose tissue;
   Cardio-vascular diseases; Depression; metabolic syndrome; Physical
   exercise
ID CORONARY-HEART-DISEASE; MIDDLE-AGED WOMEN; TYPE-2 DIABETES-MELLITUS;
   METABOLIC SYNDROME; VISCERAL FAT; RISK-FACTOR; CARDIOVASCULAR-DISEASE;
   MYOCARDIAL-INFARCTION; COMORBID DEPRESSION; BODY-WEIGHT
AB Objective: Major depressive disorder (MDD) is associated with increased amounts of intra-abdominal and epicardial adipose tissue, risk factors for the development of cardio-metabolic disorders. Exercise has been shown to reduce intra-abdominal fat in different conditions such as obesity and diabetes mellitus, thereby reducing cardio-metabolic risks. Therefore we examined the effects of exercise on adipose tissue compartments in patients with MDD.
   Methods: Of thirty depressed patients included, twenty received supervised exercise training, and ten received no specific training. Volumes of subcutaneous, intra-abdominal and epicardial adipose tissue were measured using magnetic resonance imaging, and factors constituting the metabolic syndrome were determined.
   Results: Significant effects of the training condition were observed on the amount of epicardial adipose tissue (P=0.017), subcutaneous adipose tissue (P=0.023), weight (P=0.047), body-mass index (P=0.04), high density lipoproteins (P=0.021) and the number of metabolic syndrome factors (P=0.018). The amount of intra-abdominal adipose tissue decreased slightly, although not significantly, in the exercise group.
   Conclusion: Exercise training reduces the amount of visceral, in particular epicardial adipose tissue, in patients with MDD, and ameliorates factors constituting the metabolic syndrome. Given the high prevalence of cardio-metabolic disorders in major depression, exercise training may be recommended as an additional treatment component. (C) 2015 Elsevier B.V. All rights reserved.
C1 [Kahl, K. G.; Herrmann, J.; Borchert, L.; Ates, Zeynep] Hannover Med Sch MHH, Dept Psychiat Social Psychiat & Psychotherapy, Carl Neuberg St 1, Hannover, Germany.
   [Hueper, K.; Hartung, D.] MHH, Inst Diagnost & Intervent Radiol, Hannover, Germany.
   [Kahl, K. G.; Kerling, A.; Tegtbur, U.; Guetzlaff, E.; Herrmann, J.; Borchert, L.; Ates, Zeynep; Westhoff-Bleck, M.; Hueper, K.; Hartung, D.] MHH, Dept Neurol, Hannover, Germany.
   [Kerling, A.; Tegtbur, U.; Guetzlaff, E.] Hannover Med Sch, Inst Sports Med, Carl Neuberg St 1, D-30625 Hannover, Germany.
   [Westhoff-Bleck, M.] MHH, Dept Cardiol & Angiol, Hannover, Germany.
C3 Hannover Medical School; Hannover Medical School; Hannover Medical
   School; Hannover Medical School; Hannover Medical School
RP Kahl, KG (corresponding author), Hannover Med Sch, Dept Psychiat Social Psychiat & Psychotherapy, Carl Neuberg St 1, D-30625 Hannover, Germany.
EM kahl.kai@mh-hannover.de
RI Hueper, Katja/J-9566-2016
FU Servier
FX Kai G. Kahl received speaker honoraria from Eli Lilly, BMS, Otsuka,
   Servier, Lundbeck and Janssen-Cilag and a research grant from Servier.
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NR 72
TC 38
Z9 41
U1 0
U2 19
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD MAR 1
PY 2016
VL 192
BP 91
EP 97
DI 10.1016/j.jad.2015.12.015
PG 7
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA DB8UG
UT WOS:000368791600014
PM 26707353
DA 2025-06-11
ER

PT J
AU Iyer, A
   Panchal, S
   Poudyal, H
   Brown, L
AF Iyer, Abishek
   Panchal, Sunil
   Poudyal, Hemant
   Brown, Lindsay
TI Potential Health Benefits of Indian Spices in the Symptoms of the
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SO INDIAN JOURNAL OF BIOCHEMISTRY & BIOPHYSICS
LA English
DT Review
DE Spices; Diabetes; Cardiovascular disease; Metabolic syndrome;
   Inflammation; Oxidative stress; Nutraceuticals; Food safety
ID INTERNATIONAL-DIABETES-FEDERATION; IMPROVES INSULIN SENSITIVITY; LEAF
   MURRAYA-KOENIGII; CUMINUM-CYMINUM L.; BLOOD-PRESSURE; HIGH-FAT;
   OXIDATIVE STRESS; FENUGREEK SEEDS; ADIPOSE-TISSUE; CURRY LEAF
AB Spices used in Indian cooking have it long history of use as medicines to prevent and treat diseases. Many Studies have confirmed that spices can be useful medicines, but the major challenge is now to provide scientific evidence and plausible mechanisms for their therapeutic responses. This review focuses on the therapeutic potential of Indian spices to treat multiple symptoms of the metabolic syndrome Such its insulin resistance, diabetes, obesity, altered lipid profile and hypertension. The metabolic syndrome is prevalent and has become an important financial burden to the healthcare system in both developed and developing countries. Inflammation and oxidative stress have been proposed as initiators of the metabolic syndrome, especially of insulin resistance. Natural products with anti-inflammatory and anti-oxidant properties are found in spices. Adequate doses of these compounds may be effective in treating the metabolic syndrome. Testing these potential treatments requires adequate animal models, usually rodents, so the limitations of these models are important. Furthermore, this review highlights the need for adequate legislation and regulation to ensure the safety and success of evidence-based functional foods and nutraceuticals.
C1 [Iyer, Abishek; Panchal, Sunil; Poudyal, Hemant; Brown, Lindsay] Univ Queensland, Sch Biomed Sci, Brisbane, Qld 4072, Australia.
C3 University of Queensland
RP Brown, L (corresponding author), Univ Queensland, Sch Biomed Sci, Brisbane, Qld 4072, Australia.
EM l.brown@uq.edu.au
RI Poudyal, Hemant/HOH-9324-2023; Iyer, Abishek/C-9767-2017
OI Panchal, Sunil K/0000-0001-5464-3376; Iyer, Abishek/0000-0001-9533-5265
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NR 156
TC 29
Z9 35
U1 0
U2 14
PU NATL INST SCIENCE COMMUNICATION-NISCAIR
PI NEW DELHI
PA DR K S KRISHNAN MARG, PUSA CAMPUS, NEW DELHI 110 012, INDIA
SN 0301-1208
EI 0975-0959
J9 INDIAN J BIOCHEM BIO
JI Indian J. Biochem. Biophys.
PD DEC
PY 2009
VL 46
IS 6
SI SI
BP 467
EP 481
PG 15
WC Biochemistry & Molecular Biology; Biophysics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics
GA 571ZB
UT WOS:000275794100006
PM 20361710
DA 2025-06-11
ER

PT J
AU Martemucci, G
   Fracchiolla, G
   Muraglia, M
   Tardugno, R
   Dibenedetto, RS
   D'Alessandro, AG
AF Martemucci, Giovanni
   Fracchiolla, Giuseppe
   Muraglia, Marilena
   Tardugno, Roberta
   Dibenedetto, Roberta Savina
   D'Alessandro, Angela Gabriella
TI Metabolic Syndrome: A Narrative Review from the Oxidative Stress to the
   Management of Related Diseases
SO ANTIOXIDANTS
LA English
DT Review
DE metabolic syndrome; diabesity; gut microbiota; dysbiosis; cardiovascular
   diseases; neurodegeneration
ID LOW-DENSITY-LIPOPROTEIN; GLYCATION END-PRODUCTS; BODY-MASS INDEX; GUT
   MICROBIOTA COMPOSITION; SUGAR-SWEETENED BEVERAGES; TYPE-2
   DIABETES-MELLITUS; BILE-ACID METABOLISM; FATTY LIVER-DISEASE; C-REACTIVE
   PROTEIN; ADIPOSE-TISSUE INFLAMMATION
AB Metabolic syndrome (MS) is a growing disorder affecting thousands of people worldwide, especially in industrialised countries, increasing mortality. Oxidative stress, hyperglycaemia, insulin resistance, inflammation, dysbiosis, abdominal obesity, atherogenic dyslipidaemia and hypertension are important factors linked to MS clusters of different pathologies, such as diabesity, cardiovascular diseases and neurological disorders. All biochemical changes observed in MS, such as dysregulation in the glucose and lipid metabolism, immune response, endothelial cell function and intestinal microbiota, promote pathological bridges between metabolic syndrome, diabesity and cardiovascular and neurodegenerative disorders. This review aims to summarise metabolic syndrome's involvement in diabesity and highlight the link between MS and cardiovascular and neurological diseases. A better understanding of MS could promote a novel strategic approach to reduce MS comorbidities.
C1 [Martemucci, Giovanni] Univ Bari Aldo Moro, Dept Agr & Environm Sci, I-70126 Bari, Italy.
   [Fracchiolla, Giuseppe; Muraglia, Marilena; Tardugno, Roberta; Dibenedetto, Roberta Savina] Univ Bari Aldo Moro, Dept Pharm Drug Sci, I-70126 Bari, Italy.
   [D'Alessandro, Angela Gabriella] Univ Bari Aldo Moro, Dept Soil Plant & Food Sci, I-70126 Bari, Italy.
C3 Universita degli Studi di Bari Aldo Moro; Universita degli Studi di Bari
   Aldo Moro; Universita degli Studi di Bari Aldo Moro
RP Fracchiolla, G (corresponding author), Univ Bari Aldo Moro, Dept Pharm Drug Sci, I-70126 Bari, Italy.
EM gmartem@libero.it; giuseppe.fracchiolla@uniba.it;
   marilena.muraglia@uniba.it; roberta.tardugno@uniba.it;
   roberta.dibenedetto@uniba.it; angelagabriella.dalessandro@uniba.it
RI D'Alessandro, Angela/AAN-9075-2020; Tardugno, Roberta/I-8161-2018;
   FRACCHIOLLA, Giuseppe/P-3899-2015; marilena, Muraglia/GZN-1372-2022
OI Dibenedetto, Roberta Savina/0009-0000-0396-4241; FRACCHIOLLA,
   Giuseppe/0000-0003-4991-3962; TARDUGNO, Roberta/0000-0001-9309-5966;
   marilena, Muraglia/0000-0001-9185-8405; D'Alessandro, Angela
   Gabriella/0000-0002-1506-5427
FU Innovation and Competitiveness Cooperation Programme Interreg V/A
   Greece-Italy (EL-IT) 2014-2020; National Recovery and Resilience Plan;
   ONFOODS (research and innovation network on food and nutrition
   sustainability, safety and security, working ON Foods)
FX This research was part of the National Recovery and Resilience Plan
   (PNRR); ONFOODS (research and innovation network on food and nutrition
   sustainability, safety and security, working ON Foods); and Spoke 06
   'Tackling Malnutrition' on developing nutritional strategies targeting
   the most vulnerable categories of the national population.
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NR 609
TC 18
Z9 18
U1 3
U2 13
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD DEC
PY 2023
VL 12
IS 12
AR 2091
DI 10.3390/antiox12122091
PG 46
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA DH6E8
UT WOS:001131170400001
PM 38136211
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Castilho, JL
   Rebeiro, PF
   Shepherd, BE
   Nash, R
   Adams, RS
   Turner, M
   Furukawa, SS
   Hulgan, T
   Koethe, JR
   Sterling, TR
AF Castilho, Jessica L.
   Rebeiro, Peter F.
   Shepherd, Bryan E.
   Nash, Robertson
   Adams, Rodney S.
   Turner, Megan
   Furukawa, Sally S.
   Hulgan, Todd
   Koethe, John R.
   Sterling, Timothy R.
TI Mood Disorders and Increased Risk of Noncommunicable Disease in Adults
   With HIV
SO JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
LA English
DT Article; Proceedings Paper
CT 26th Conference on Retroviruses and Opportunistic Infections (CROI)
CY MAR 04-07, 2019
CL Seattle, WA
DE HIV; depression; noncommunicable disease; multimorbidity; aging;
   metabolic syndrome
ID HUMAN-IMMUNODEFICIENCY-VIRUS; CARDIOVASCULAR-DISEASE; METABOLIC
   SYNDROME; OLDER-ADULTS; DEPRESSION; INFECTION; AGE; POPULATION;
   COMORBIDITIES; INFLAMMATION
AB Background: People living with HIV (PLWH) experience high rates of mood disorders (major depression and bipolar affective disorder) which in the general population have been associated with noncommunicable disease (NCD) risk. We examined whether prevalent mood disorders are associated with incident NCDs and multimorbidity (accumulation of >= 2 NCDs) in PLWH. Setting: Adult HIV clinic cohort in Nashville, Tennessee, between 1998 and 2015. Methods: PLWH with >= 1 year of follow-up in the clinic were assessed for cardiovascular disease, metabolic syndrome (any 3 of hypertension, hyperlipidemia, diabetes, or obesity), chronic kidney and liver disease, non-AIDS-defining cancers, and dementia. Only mood disorders documented during the first year of care were included. Cumulative incidence and adjusted subhazard ratios (aSHRs) were calculated for risk of NCDs and multimorbidity with death as a competing risk. Multivariable Cox models estimated mortality risk after multimorbidity. Results: Of 4140 adults, 24% had a mood disorder diagnosed in the first year of care, 51% had >= 1 NCD at baseline, and there were 2588 incident NCDs during the study period. Mood disorders were associated with increased risk of first NCD (aSHR = 1.29, 95% confidence interval: 1.06 to 1.57), incident multimorbidity (aSHR ranging from 1.04 to 1.42), and metabolic syndrome (aSHR = 1.29, 95% confidence interval: 1.02 to 1.64). Mood disorders were not conclusively associated with mortality risk after multimorbidity. Conclusions: PLWH with mood disorders were at increased risk of incident NCDs and multimorbidity, particularly metabolic syndrome. Focused prevention and treatment of NCDs may reduce the burden of multimorbidity in this high-risk group.
C1 [Castilho, Jessica L.; Rebeiro, Peter F.; Nash, Robertson; Adams, Rodney S.; Turner, Megan; Furukawa, Sally S.; Hulgan, Todd; Koethe, John R.; Sterling, Timothy R.] Vanderbilt Univ, Med Ctr, Dept Med, Div Infect Dis, Nashville, TN USA.
   [Rebeiro, Peter F.; Shepherd, Bryan E.] Vanderbilt Univ, Med Ctr, Dept Biostat, Nashville, TN USA.
C3 Vanderbilt University; Vanderbilt University
RP Castilho, JL (corresponding author), Vanderbilt Univ, Med Ctr, A2200 Med Ctr North,1161 21st Ave South, Nashville, TN 37232 USA.
EM jessica.castilho@vumc.org
RI Koethe, John/LVA-2588-2024; Rebeiro, Peter/KUC-9148-2024; Hulgan,
   Todd/AAG-7491-2019
OI Rebeiro, Peter/0000-0003-1951-9104
FU National Institutes of Health; NIH-funded Tennessee Center for AIDS
   Research [P30 AI110527, K23AI112087, K01AI131895, P30AI110527]
FX Supported by grant funding by the National Institutes of Health: K23
   AI120875 (J.L.C.) and by the NIH-funded Tennessee Center for AIDS
   Research (P30 AI110527). J.L.C. is currently receiving a grant
   (K23AI112087) as is P.F.R. (K01AI131895), and P.F.R., B.E.S., M.T.,
   S.S.F., and T.R.S. are supported by a separate grant (P30AI110527) from
   the National Institutes of Health.
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NR 41
TC 10
Z9 12
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1525-4135
EI 1077-9450
J9 JAIDS-J ACQ IMM DEF
JI JAIDS
PD APR 1
PY 2020
VL 83
IS 4
BP 397
EP 404
DI 10.1097/QAI.0000000000002269
PG 8
WC Immunology; Infectious Diseases
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI); Conference Proceedings Citation Index - Science (CPCI-S)
SC Immunology; Infectious Diseases
GA LB1ER
UT WOS:000524379500013
PM 32097195
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Ruperez, AI
   Mesa, MD
   Anguita-Ruiz, A
   González-Gil, EM
   Vázquez-Cobela, R
   Moreno, LA
   Gil, A
   Gil-Campos, M
   Leis, R
   Bueno, G
   Aguilera, CM
AF Ruperez, Azahara, I
   Mesa, Maria D.
   Anguita-Ruiz, Augusto
   Gonzalez-Gil, Esther M.
   Vazquez-Cobela, Rocio
   Moreno, Luis A.
   Gil, Angel
   Gil-Campos, Mercedes
   Leis, Rosaura
   Bueno, Gloria
   Aguilera, Concepcion M.
TI Antioxidants and Oxidative Stress in Children: Influence of Puberty and
   Metabolically Unhealthy Status
SO ANTIOXIDANTS
LA English
DT Article
DE carotenoids; tocopherols; oxidized low-density lipoprotein; inflammatory
   biomarkers; childhood obesity; metabolically healthy; metabolic syndrome
ID HOMEOSTASIS MODEL ASSESSMENT; DENSITY-LIPOPROTEIN LEVELS;
   INSULIN-RESISTANCE; OBESE CHILDREN; VITAMIN-E; ENDOTHELIAL DYSFUNCTION;
   ALPHA-TOCOPHEROL; OXIDIZED LDL; CARDIOMETABOLIC RISK; SERUM
   CONCENTRATIONS
AB Oxidative stress could help explain the relationship between childhood obesity and a metabolically unhealthy (MU) status. Moreover, puberty could also influence this relationship, since it entails physiological cardiometabolic changes. We aimed to evaluate plasma antioxidants and oxidative stress biomarkers in MU and metabolically healthy (MH) prepubertal and pubertal children and their associations with pro-inflammatory and endothelial damage biomarkers, taking puberty into account. A total of 1444 Spanish children aged 3-17 years (48.9% males, 66% prepubertal, 47.1% with obesity) were recruited. Blood pressure, anthropometric and biochemical parameters were measured, and children were categorized as having a MU or MH status according to risk factors. Retinol, carotenes, tocopherols, total antioxidant capacity (TAC), oxidized low-density lipoprotein and selected pro-inflammatory and endothelial damage biomarkers were analyzed. General linear models adjusted for age, sex, recruitment center and body mass index, partial correlations and stepwise linear regressions were performed. Lower carotenes and tocopherols levels were found in MU than in MH children. Plasma TAC was lower in prepubertal and higher in pubertal children with obesity compared to normal-weight children. Antioxidants and oxidative stress biomarkers showed novel associations with several pro-inflammatory and endothelial damage biomarkers, with pubertal differences, supporting the importance of considering both the antioxidant and oxidative stress status and puberty in the prevention of metabolic diseases in childhood.
C1 [Ruperez, Azahara, I; Gonzalez-Gil, Esther M.; Moreno, Luis A.; Bueno, Gloria] Univ Zaragoza, Inst Agroalimentario Aragon IA2, Inst Invest Sanitaria IIS Aragon, GENUD Res Grp, Zaragoza 50013, Spain.
   [Mesa, Maria D.; Anguita-Ruiz, Augusto; Gonzalez-Gil, Esther M.; Gil, Angel; Aguilera, Concepcion M.] Univ Granada, Ctr Biomed Res, Inst Nutr & Food Technol Jose Mataix, Dept Biochem & Mol Biol 2, Granada 18016, Spain.
   [Mesa, Maria D.; Anguita-Ruiz, Augusto; Gil, Angel; Aguilera, Concepcion M.] Inst Invest Biosanitaria Ibs, Granada 18014, Spain.
   [Anguita-Ruiz, Augusto; Gonzalez-Gil, Esther M.; Vazquez-Cobela, Rocio; Moreno, Luis A.; Gil, Angel; Gil-Campos, Mercedes; Leis, Rosaura; Bueno, Gloria; Aguilera, Concepcion M.] Inst Hlth Carlos III ISCIII, CIBEROBN, Physiopathol Obes & Nutr Network, Madrid 28029, Spain.
   [Vazquez-Cobela, Rocio; Leis, Rosaura] Clin Univ Hosp Santiago, Inst Invest Sanitaria Santiago IDIS, Pediat Dept, Pediat Gastroenterol Hepatol & Nutr Unit, Santiago De Compostela 15706, Spain.
   [Gil-Campos, Mercedes] Univ Cordoba, Reina Sofia Univ Hosp, Maimonides Inst Biomed Res Cordoba IMIBIC, Metab & Invest Unit, Cordoba 14004, Spain.
   [Leis, Rosaura] Univ Santiago de Compostela, Pediat Dept, Unit Invest Nutr Growth & Human Dev Galicia, Santiago De Compostela 15782, Spain.
   [Bueno, Gloria] Univ Zaragoza, Clin Univ Hosp Lozano Blesa, Fac Med, Pediat Endocrinol Unit, Zaragoza 50009, Spain.
C3 University of Zaragoza; Leibniz Association; Leibniz Institute for
   Prevention Research & Epidemiology (BIPS); University of Granada;
   Instituto de Investigacion Biosanitaria IBS Granada; CIBER - Centro de
   Investigacion Biomedica en Red; CIBEROBN; Complexo Hospitalario
   Universitario de Santiago de Compostela; Universidad de Cordoba;
   Universidade de Santiago de Compostela; University of Zaragoza; Lozano
   Blesa University Clinical Hospital
RP Bueno, G (corresponding author), Univ Zaragoza, Inst Agroalimentario Aragon IA2, Inst Invest Sanitaria IIS Aragon, GENUD Res Grp, Zaragoza 50013, Spain.; Bueno, G (corresponding author), Inst Hlth Carlos III ISCIII, CIBEROBN, Physiopathol Obes & Nutr Network, Madrid 28029, Spain.; Bueno, G (corresponding author), Univ Zaragoza, Clin Univ Hosp Lozano Blesa, Fac Med, Pediat Endocrinol Unit, Zaragoza 50009, Spain.
EM airuperez@unizar.es; mdmesa@ugr.es; augustoanguita@ugr.es;
   esthergg@ugr.es; cobela.rocio@gmail.com; lmoreno@unizar.es; agil@ugr.es;
   mercedes_gil_campos@yahoo.es; mariarosaura.leis@usc.es;
   mgbuenol@unizar.es; caguiler@ugr.es
RI BUENO, Maria/AAG-9985-2021; Anguita-Ruiz, Augusto/AAE-9827-2019; Leis,
   Rosaura/Z-3186-2019; Rupérez, Azahara/L-3771-2019; Moreno,
   Luis/S-1780-2019; Vazquez Cobela, Rocio/ABF-5488-2020; Gil,
   Angel/L-2275-2014; Anguita-Ruiz, Augusto/X-7448-2018; Aguilera,
   Concepcion/M-1663-2014; Mesa, Maria/M-3523-2014; Gonzalez Gil, Esther
   Maria/AAA-8040-2020
OI Vazquez Cobela, Rocio/0000-0002-3155-1601; Moreno Aznar, Luis
   A./0000-0003-0454-653X; Gil-Campos, Mercedes/0000-0002-9007-0242;
   Ruperez, Azahara I./0000-0002-3850-8235; Gil, Angel/0000-0001-7663-0939;
   Anguita-Ruiz, Augusto/0000-0001-6888-1041; Aguilera,
   Concepcion/0000-0002-1451-4788; Mesa, Maria/0000-0003-4079-6464; Leis,
   Rosaura/0000-0002-0540-4210; Gonzalez Gil, Esther
   Maria/0000-0003-2005-8229
FU Plan Nacional de Investigacion Cientifica, Desarrollo e Innovacion
   Tecnologica (I + D + I), Instituto de Salud Carlos III-Health Research
   Funding (FONDOS FEDER) [PI051968, PI11/01425, PI1102042, PI11/02059,
   PI16/01301, PI16/012, PI1600871]; CIBEROBN Network [CB12/03/30038,
   CB15/00131, CB15/00043]
FX This research was supported by the Plan Nacional de Investigacion
   Cientifica, Desarrollo e Innovacion Tecnologica (I + D + I), Instituto
   de Salud Carlos III-Health Research Funding (FONDOS FEDER) (PI051968,
   PI11/01425, PI1102042, PI11/02059, PI16/01301, PI16/012 and PI1600871);
   CIBEROBN Network (CB12/03/30038, CB15/00131, CB15/00043). The authors
   also acknowledge the University of Granada 'Plan Propio de Investigacion
   2016-Excellence actions: Unit of Excellence on Exercise and Health
   (UCEES)'.
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NR 72
TC 27
Z9 27
U1 0
U2 9
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD JUL
PY 2020
VL 9
IS 7
AR 618
DI 10.3390/antiox9070618
PG 19
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA MX1ZY
UT WOS:000557527100001
PM 32679739
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Tucovic, D
   Aleksandrov, AP
   Popovic, D
   Malesevic, A
   Subota, V
   Brdaric, E
   Bajic, SS
   Zivkovic, M
   Kataranovski, M
   Mirkov, I
   Stanojevic, S
   Kulas, J
AF Tucovic, Dina
   Popov Aleksandrov, Aleksandra
   Popovic, Dusanka
   Malesevic, Anastasija
   Subota, Vesna
   Brdaric, Emilija
   Sokovic Bajic, Svetlana
   Zivkovic, Milica
   Kataranovski, Milena
   Mirkov, Ivana
   Stanojevic, Stanislava
   Kulas, Jelena
TI Differential Proneness to Obesity in Two Rat Strains with Diverse Immune
   Responses
SO BIOLOGY-BASEL
LA English
DT Article
DE Dark Agouti (DA) rat strain; Albino Oxford (AO) rat strain; obesity;
   metabolic syndrome; coagulation parameters; oxidative stress and
   inflammation; gut microbiota metabolic pathways
ID EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; DIET-INDUCED OBESITY;
   METABOLIC SYNDROME; ALBINO OXFORD; ADJUVANT ARTHRITIS; DARK AGOUTI;
   BODY-WEIGHT; SUSCEPTIBILITY; RESISTANCE; AGE
AB Although obesity and metabolic syndrome (comprising at least three of the following traits-abdominal obesity, elevated blood pressure, triglycerides and glucose/insulin resistance, and reduced high-density lipoprotein cholesterol in serum) are known to impact immune system activity, these conditions are often not considered when immune response characteristics are investigated in various rodent strains. In this work, metabolic syndrome indices are compared in 3 month-old (young) and 6 month-old (adult) rats of Dark Agouti (DA) and Albino Oxford (AO) strains, while parameters of coagulation, inflammation and oxidative stress were determined in young animals. Study reveals that both young and adult AO rats are obese, intolerant to glucose with higher levels of triglycerides and lower levels of high-density lipoprotein cholesterol when compared to age-matched DA rats. Parameters of coagulation, inflammation and oxidative stress that may contribute to the worsening of metabolic syndrome during aging are also higher in young AO rats. Metabolic syndrome observed in young and intensified in adult AO rats should be taken into consideration when analyzing alterations in immune reactivity during aging in this rat strain.
C1 [Tucovic, Dina; Popov Aleksandrov, Aleksandra; Popovic, Dusanka; Malesevic, Anastasija; Kataranovski, Milena; Mirkov, Ivana; Stanojevic, Stanislava; Kulas, Jelena] Univ Belgrade, Inst Biol Res Sinisa Stankovic, Dept Ecol, Immunotoxicol Grp,Natl Inst Republ Serbia, Belgrade 11000, Serbia.
   [Subota, Vesna] Mil Med Acad, Inst Med Biochem, Belgrade 11000, Serbia.
   [Brdaric, Emilija; Sokovic Bajic, Svetlana; Zivkovic, Milica] Univ Belgrade, Inst Mol Genet & Genet Engn, Dept Microbiol & Plant Biol, Grp Probiot & Microbiota Host Interact, Belgrade 11000, Serbia.
C3 University of Belgrade; University of Belgrade
RP Kulas, J (corresponding author), Univ Belgrade, Inst Biol Res Sinisa Stankovic, Dept Ecol, Immunotoxicol Grp,Natl Inst Republ Serbia, Belgrade 11000, Serbia.
EM dina.mileusnic@ibiss.bg.ac.rs; aleksandrap@ibiss.bg.ac.rs;
   dusanka.popovic@ibiss.bg.ac.rs; anastasija.malesevic@ibiss.bg.ac.rs;
   subota.vesna@gmail.com; emilija.brdaric@imgge.bg.ac.rs;
   svetlana.sokovic@imgge.bg.ac.rs; milica.zivkovic@imgge.bg.ac.rs;
   m.kataranovski@gmail.com; mirkovi@ibiss.bg.ac.rs;
   stanislava.stanojevic@ibiss.bg.ac.rs; jkulas@ibiss.bg.ac.rs
RI Mirkov, Ivana/AAX-3931-2020; Kulas, Jelena/JQT-3455-2023; Tucovic,
   Dina/LKM-0602-2024; Malesevic, Anastasija/JQV-7809-2023; Popovic,
   Dusanka/JQV-7823-2023
FU Ministry of Science, Technological Development and Innovations of the
   Republic of Serbia;  [451-03-66/2024-03/200007]; 
   [451-03-66/2024-03/200042]
FX This research was funded by the Ministry of Science, Technological
   Development and Innovations of the Republic of Serbia (Grant No
   451-03-66/2024-03/200007 and 451-03-66/2024-03/200042).
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NR 110
TC 0
Z9 0
U1 0
U2 0
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2079-7737
J9 BIOLOGY-BASEL
JI Biology-Basel
PD MAY 16
PY 2025
VL 14
IS 5
AR 557
DI 10.3390/biology14050557
PG 24
WC Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics
GA 3BW5A
UT WOS:001496636800001
PM 40427746
OA gold
DA 2025-06-11
ER

PT J
AU Liu, B
   Zhang, LY
   Cai, YS
   Zhang, M
   Huang, WX
   Yan, XH
   Chen, HF
AF Liu, Bin
   Zhang, Lingyu
   Cai, Yashi
   Zhang, Min
   Huang, Weixu
   Yan, Xuehua
   Chen, Huifeng
TI Correlation analysis of occupational stress and metabolic syndrome among
   employees of a power grid enterprise in China
SO WORK-A JOURNAL OF PREVENTION ASSESSMENT & REHABILITATION
LA English
DT Article
DE Power grid enterprise; occupational health; occupational stress; job
   demand-control; effort-reward imbalance; metabolic syndrome
ID EFFORT-REWARD IMBALANCE; WORK-RELATED STRESS; DEMAND-CONTROL; JOB
   STRAIN; BLOOD-PRESSURE; HEALTH; ASSOCIATIONS; HYPERTENSION; CORTISOL;
   RISK
AB BACKGROUND: Being in a state of high occupational stress may disrupt the metabolic balance of the body, thus increasing the risk of metabolic diseases. However, the evidence about the relationship between occupational stress and metabolic syndrome was limited.OBJECTIVES: To explore the association between occupational stress and metabolic syndrome (MetS) in employees of a power grid enterprise.METHODS: A total of 1091 employees were recruited from a power grid enterprise in China. Excluding those who failed to complete the questionnaire and those who had incomplete health check-ups, 945 subjects were included in the study. Assessment of occupational stress was used by job demand-control (JDC) and effort-reward imbalance (ERI) questionnaires, respectively. The information on body mass index (BMI), systolic blood pressure (SBP), and diastolic blood pressure (DBP) were collected. The levels of high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), and fasting blood glucose (FBG) in the fasting venous blood samples were measured. Logistic regression analysis and multiple linear regression methods were used to analyze the correlation between JDC and ERI models of occupational stress, metabolic syndrome, and its components, respectively.RESULTS: The prevalence of MetS was 8.4% and 9.9% in JDC and ERI model high occupational stress employees, respectively. ERI model occupational stress and smoking are significantly associated with the risk of MetS. ERI ratio was significantly associated with lower HDL-C levels. Gender, age, marital status, smoking, high-temperature and high-altitude work were significantly associated with metabolic component levels.CONCLUSION: Our study revealed a high detection rate of occupational stress in both JDC and ERI models among employees of a power grid enterprise. ERI model occupational stress, demanding more attention, was associated with the risk of MetS as well as its components such as HDL-C.
C1 [Liu, Bin; Zhang, Lingyu; Cai, Yashi; Zhang, Min; Huang, Weixu; Yan, Xuehua; Chen, Huifeng] Guangdong Prov Hosp Occupat Dis Prevent & Treatmen, Guangzhou 510300, Guangdong, Peoples R China.
   [Liu, Bin] Shenzhen Luohu Peoples Hosp, Dept Prevent Med, Shenzhen, Guangdong, Peoples R China.
   [Zhang, Lingyu; Chen, Huifeng] Guangzhou Med Univ, Sch Publ Hlth, Guangzhou, Guangdong, Peoples R China.
C3 Shenzhen Luohu Hospital Group Luohu People's Hospital; Guangzhou Medical
   University
RP Chen, HF (corresponding author), Guangdong Prov Hosp Occupat Dis Prevent & Treatmen, Guangzhou 510300, Guangdong, Peoples R China.
EM chenhf@gdpcc.com
OI Lingyu, Zhang/0000-0001-8717-7412; Chen, Huifeng/0000-0002-5381-1793
FU Medical Scientific Research Foundation of Guangdong Province [A2019246,
   A2021209]; Guangzhou Science and Technology Plan Project [202102080135]
FX We gratefully acknowledge funding from the Medical Scientific Research
   Foundation of Guangdong Province (grant numbers: A2019246, A2021209) and
   the Guangzhou Science and Technology Plan Project (grant numbers:
   202102080135).
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NR 50
TC 0
Z9 0
U1 0
U2 1
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1051-9815
EI 1875-9270
J9 WORK
JI Work
PD JAN
PY 2025
VL 80
IS 1
BP 107
EP 121
DI 10.3233/WOR-240234
PG 15
WC Public, Environmental & Occupational Health
WE Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA 1BR5G
UT WOS:001461203000021
PM 39093109
DA 2025-06-11
ER

PT J
AU Oliveira, ECD
   Barbosa, GC
   Corrente, JE
   Komuro, JE
   Papini, SJ
AF Dona Oliveira, Elen Cristiane
   Barbosa, Guilherme Correa
   Corrente, Jose Eduardo
   Komuro, Jessica Emy
   Papini, Silvia Justina
TI Oat bran in cardiovascular risk control in mental disorder
SO REVISTA BRASILEIRA DE ENFERMAGEM
LA English
DT Article
DE Schizophrenia; Metabolic Syndrome; Dietary Fiber; Oats; Chronic Diseases
ID ALCOHOL-CONSUMPTION; BINGE DRINKING; OBESITY; ADULTS; EPIDEMIOLOGY;
   OVERWEIGHT
AB Objective: To evaluate the effect of oat bran supplementation on cardiovascular risk components of patients with mental disorders. Method: A before-and-after study, no control group. Cardiovascular risk indicators were assessed at baseline (M0), 90 (M1), 180 days (M2) and 180 days after supplementation (M3). Results: Of the 45 patients admitted to a psychiatric institution using antipsychotics, more than two thirds had high cardiovascular risk assessed by abdominal obesity. Forty-six point seven percent were overweight and 31.1% metabolic syndrome. Oat bran was effective in reducing serum cholesterol (M0-M1), HDL-cholesterol (M1-M2), triglycerides (M1-M2), (M2-M3) and (M1-M3). In M3, there was a statistical difference for all indicators evaluated. Conclusion: Oat bran supplementation was effective in improving triglyceride, total cholesterol and HDL-cholesterol levels, suggesting that it is a therapeutic option for cardiovascular risk control in patients with psychiatric disorders.
C1 [Dona Oliveira, Elen Cristiane; Barbosa, Guilherme Correa; Corrente, Jose Eduardo; Komuro, Jessica Emy; Papini, Silvia Justina] Univ Estadual Paulista, Botucatu, SP, Brazil.
C3 Universidade Estadual Paulista
RP Papini, SJ (corresponding author), Univ Estadual Paulista, Botucatu, SP, Brazil.
EM silvia.papini@unesp.br
RI Corrente, José/AAG-1838-2019; Correa Barbosa, Guilherme/F-3918-2019;
   Corrente, Jose/C-4022-2012
OI Correa Barbosa, Guilherme/0000-0002-7433-8237; Corrente,
   Jose/0000-0001-5478-4996
FU Research Support Foundation of Minas Gerais (FAPEMIG -Fundacao de Amparo
   a Pesquisa de Minas Gerais) [CDS-APQ-00571/13, CDS-APQ-02407/16,
   CDS-APQ-00424/17]
FX Research Support Foundation of Minas Gerais (FAPEMIG -Fundacao de Amparo
   a Pesquisa de Minas Gerais), processes CDS-APQ-00571/13,
   CDS-APQ-02407/16, CDS-APQ-00424/17.
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   [No title captured]
NR 33
TC 2
Z9 3
U1 0
U2 2
PU ASSOC BRASILEIRA ENFERMAGEM
PI BRASILIA DF
PA SGA NORTE QUADRA 603 CONJ B AV L2 NORTE, BRASILIA DF, 70830-030, BRAZIL
SN 0034-7167
EI 1984-0446
J9 REV BRAS ENFERM
JI Rev. Bras. Enferm.
PY 2020
VL 73
SU 1
AR UNSP e20190277
DI 10.1590/0034-7167-2019-0277
PG 15
WC Nursing
WE Emerging Sources Citation Index (ESCI)
SC Nursing
GA LU7QQ
UT WOS:000537945800017
PM 32490954
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Son, H
   Kim, H
AF Son, Heesook
   Kim, Hyerang
TI Influence of Living Arrangements and Eating Behavior on the Risk of
   Metabolic Syndrome: A National Cross-Sectional Study in South Korea
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Article
DE eating behavior; living arrangement; metabolic syndrome; dietary
   patterns; adults
ID CARDIOVASCULAR-DISEASE RISK; DIETARY PATTERNS; FOOD CHOICES; NUTRITION;
   HEALTH; ADOLESCENTS; DEPRESSION; FREQUENCY; CHILDREN; STUDENTS
AB Studies on the relationships between health, different living arrangements, and eating behaviors across age groups are limited. Therefore, we investigated these associations, focusing on metabolic syndrome, among 16,015 South Koreans aged 19 years who completed the Korean National Health and Nutrition Examination Survey (2013-2016). Multivariate logistic regression revealed that younger adults (<65 years) who lived and ate alone consumed more carbohydrates than those who lived and ate with others (p < 0.01). The odds of metabolic syndrome in younger adults increased with eating alone (adjusted odds ratio (aOR) 2.11, 95% confidence interval (CI) 1.10-4.02) and living and eating alone (2.39, 1.25-4.58). Older adults (65 years) did not differ in dietary intake or prevalence of metabolic syndrome according to their living and eating situations. Younger adults living and eating alone may benefit from customized nutrition and health management programs to reduce their risk of metabolic syndrome.
C1 [Son, Heesook; Kim, Hyerang] Chung Ang Univ, Red Cross Coll Nursing, 84 Heukseok Ro, Seoul 06974, South Korea.
C3 Chung Ang University
RP Kim, H (corresponding author), Chung Ang Univ, Red Cross Coll Nursing, 84 Heukseok Ro, Seoul 06974, South Korea.
EM hson@cau.ac.kr; hkim167@hotmail.com
FU National Research Foundation of Korea Grant - Korean Government
   [NRF-2015R1C1A1A01054200]; Chung-Ang University Research Scholarship
   Grants in 2017
FX This work was supported by a National Research Foundation of Korea
   Grant, which was funded by the Korean Government
   (NRF-2015R1C1A1A01054200) and supported by Chung-Ang University Research
   Scholarship Grants in 2017.
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NR 35
TC 9
Z9 9
U1 0
U2 6
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-7827
EI 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD MAR 2
PY 2019
VL 16
IS 6
AR 919
DI 10.3390/ijerph16060919
PG 10
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA HU3GB
UT WOS:000465159500019
PM 30875777
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Kawvised, S
   Wattanathorn, J
   Thukham-mee, W
AF Kawvised, Supannika
   Wattanathorn, Jintanaporn
   Thukham-mee, Wipawee
TI Neuroprotective and Cognitive-Enhancing Effects of Microencapsulation of
   Mulberry Fruit Extract in Animal Model of Menopausal Women with
   Metabolic Syndrome
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Article
ID ANTIOXIDANT ACTIVITIES; MEMORY; ANTHOCYANIN; POLYPHENOLS; PLASTICITY;
   COMPONENTS; CAPACITY; ASSAY; ACID; MICE
AB Currently, the neuroprotectant and memory-enhancing agent for menopausal women with metabolic syndrome is required. Based on the advantages of polyphenolics on numerous changes observed in menopause with metabolic syndrome and the encapsulation method, we hypothesized that microencapsulated mulberry fruit extract (MME) could protect brain damage and improve memory impairment in an animal model of menopause with metabolic syndrome. To test this hypothesis, MME at doses of 10, 50, and 250 mg/kg was given to female Wistar rats which were induced experimental menopause with metabolic syndrome by bilateral ovariectomy (OVX) and fed with high-carbohydrate high-fat (HCHF) diet for 8 weeks. Spatial memory together with neuron density, oxidative stress status, acetylcholinesterase, and phosphorylation of Erk in the hippocampus was assessed at the end of the study. It was found that MME decreased memory impairment, oxidative stress status, and AChE activity but increased neuron density and Erk phosphorylation in the hippocampus. Therefore, the neuroprotective and memory-enhancing effects of MME might partly involve the enhanced cholinergic function and Erk phosphorylation but decreased oxidative stress status in hippocampus. Therefore, MME is the potential novel neuroprotectant and memory-enhancing agent for menopause with metabolic syndrome. However, further research especially clinical trial is still necessary.
C1 [Kawvised, Supannika] Khon Kaen Univ, Fac Med, Dept Physiol, Khon Kaen 40002, Thailand.
   [Kawvised, Supannika] Khon Kaen Univ, Fac Med, Grad Sch, Neurosci Program, Khon Kaen 40002, Thailand.
   [Kawvised, Supannika; Wattanathorn, Jintanaporn; Thukham-mee, Wipawee] Khon Kaen Univ, Integrat Complementary Alternat Med Res & Dev Ctr, Khon Kaen 40002, Thailand.
   [Wattanathorn, Jintanaporn; Thukham-mee, Wipawee] Khon Kaen Univ, Fac Med, Dept Physiol, Khon Kaen 40002, Thailand.
C3 Khon Kaen University; Khon Kaen University; Khon Kaen University; Khon
   Kaen University
RP Wattanathorn, J (corresponding author), Khon Kaen Univ, Integrat Complementary Alternat Med Res & Dev Ctr, Khon Kaen 40002, Thailand.; Wattanathorn, J (corresponding author), Khon Kaen Univ, Fac Med, Dept Physiol, Khon Kaen 40002, Thailand.
EM jintanapornw@yahoo.com
RI Kawvised, Supannika/IWM-6096-2023
OI Wattanathorn, Jintanaporn/0000-0002-7383-2348
FU Integrative Complementary Alternative Medicine Research and Development
   Center, Khon Kaen University, Khon Kaen, Thailand; Faculty of Medicine
   and Graduate School of Khon Kaen University [IN59130]; Thailand Research
   Fund via Research and Researchers for Industries (RRI); National
   Research Council of Thailand
FX This study was supported by Integrative Complementary Alternative
   Medicine Research and Development Center, Khon Kaen University, Khon
   Kaen, Thailand, Invitation Research Grant of Faculty of Medicine and
   Graduate School of Khon Kaen University (Grant no. IN59130), Thailand
   Research Fund via Research and Researchers for Industries (RRI) project,
   and The National Research Council of Thailand. The authors also would
   like to express their sincere thanks to Mr. Wiroje Kaewrueng and Queen
   Sirikit Department of Sericulture Center, Udon Thani Province, for
   providing mulberry fruit.
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NR 39
TC 27
Z9 28
U1 2
U2 23
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PY 2017
VL 2017
AR 2962316
DI 10.1155/2017/2962316
PG 13
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA FJ5IN
UT WOS:000412785000001
PM 29158872
OA Green Published, hybrid, Green Submitted
DA 2025-06-11
ER

PT J
AU Sasaki, A
   de Vega, WC
   St-Cyr, S
   Pan, P
   McGowan, PO
AF Sasaki, A.
   de Vega, W. C.
   St-Cyr, S.
   Pan, P.
   McGowan, P. O.
TI PERINATAL HIGH FAT DIET ALTERS GLUCOCORTICOID SIGNALING AND ANXIETY
   BEHAVIOR IN ADULTHOOD
SO NEUROSCIENCE
LA English
DT Article
DE glucocorticoid receptor; stress; anxiety behavior; maternal; obesity;
   gene expression programming
ID MECHANISMS LINKING OBESITY; PITUITARY-ADRENAL AXIS; INSULIN-RESISTANCE;
   GENE-EXPRESSION; PRENATAL STRESS; GENDER-DIFFERENCES; MATERNAL OBESITY;
   KAPPA-B; BRAIN; INFLAMMATION
AB Maternal obesity carries significant health risks for offspring that manifest later in life, including metabolic syndrome, cardiovascular disease and affective disorders. Programming of the hypothalamic-pituitary-adrenal (HPA) axis during development mediates both metabolic homeostasis and the response to psychosocial stress in offspring. A diet high in fat alters maternal systemic corticosterone levels, but effects in offspring on limbic brain areas regulating the HPA axis and anxiety behavior are poorly understood. In addition to their role in the response to psychosocial stress, corticosteroid receptors form part of the glucocorticoid signaling pathway comprising downstream inflammatory processes. Increased systemic inflammation is a hallmark of high-fat diet exposure, though altered expression of these genes in limbic brain areas has not been examined. We studied the influence of high-fat diet exposure during pre-weaning development in rats on gene expression in the amygdala and hippocampus by quantitative real-time polymerase chain reaction (PCR), anxiety behavior in the Open field, elevated plus maze and light-dark transition tasks, and corticosterone levels in response to stress by radioimmunoassay. As adults, offspring exposed to perinatal high-fat diet show increased expression of corticosterone receptors in the amygdala and altered pro-inflammatory and anti-inflammatory expression in the hippocampus and amygdala in genes known to be regulated by the glucocorticoid receptor. These changes were associated with increased anxiety behavior, decreased basal corticosterone levels and a slower return to baseline levels following a stress challenge. The data indicate that the dietary environment during development programs glucocorticoid signaling pathways in limbic areas relevant for the regulation of HPA function and anxiety behavior. (C) 2013 IBRO. Published by Elsevier Ltd. All rights reserved.
C1 [McGowan, P. O.] Univ Toronto, Dept Biol Sci, Toronto, ON M1C 1A4, Canada.
   Univ Toronto, Dept Cell & Syst Biol, Toronto, ON M1C 1A4, Canada.
C3 University of Toronto; University of Toronto
RP McGowan, PO (corresponding author), Univ Toronto, Dept Biol Sci, Scarborough Campus,1265 Mil Trail, Toronto, ON M1C 1A4, Canada.
EM patrick.mcgowan@utoronto.ca
FU Connaught Fund; Natural Sciences and Engineering Research Council of
   Canada (NSERC)
FX This work was supported by a New Researcher Award from the Connaught
   Fund and an operating grant from the Natural Sciences and Engineering
   Research Council of Canada (NSERC) to P.O.M.
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NR 56
TC 154
Z9 181
U1 1
U2 47
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4522
EI 1873-7544
J9 NEUROSCIENCE
JI Neuroscience
PD JUN 14
PY 2013
VL 240
BP 1
EP 12
DI 10.1016/j.neuroscience.2013.02.044
PG 12
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 142VM
UT WOS:000318825700001
PM 23454542
DA 2025-06-11
ER

PT J
AU Doom, JR
   Reid, BM
   Nagel, E
   Gahagan, S
   Demerath, EW
   Lumeng, JC
AF Doom, Jenalee R.
   Reid, Brie M.
   Nagel, Emily
   Gahagan, Sheila
   Demerath, Ellen W.
   Lumeng, Julie C.
TI Integrating anthropometric and cardiometabolic health methods in stress,
   early experiences, and development (SEED) science
SO DEVELOPMENTAL PSYCHOBIOLOGY
LA English
DT Review
DE anthropometry; body composition; cardiometabolic health; development;
   inflammation; puberty; stress
ID X-RAY ABSORPTIOMETRY; INTIMA-MEDIA THICKNESS; LOW-BIRTH-WEIGHT;
   BODY-MASS INDEX; HEART-ASSOCIATION ATHEROSCLEROSIS; AIR-DISPLACEMENT
   PLETHYSMOGRAPHY; INTRAUTERINE GROWTH RESTRICTION; TO-HEIGHT RATIO;
   CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME
AB Within Stress, Early Experiences, and Development (SEED) science, there is a growing body of research demonstrating complex associations not only between stress, development, and psychopathology, but also with chronic disease risk factors. We argue that it is important for SEED researchers to consider including child anthropometric and physical health measures to more comprehensively capture processes of risk and resilience. Broader adoption of harmonized anthropometry and health measures in SEED research will facilitate collaborations, yielding larger datasets for research in high-risk populations, and greater opportunity to replicate existing findings. In this review, we identify optimal anthropometric and cardiometabolic health measurement methods used from infancy through adolescence, including those that are low-burden and inexpensive. Methods covered include: waist, hip, and head circumference, height, length, weight, pubertal development, body composition, blood pressure, arterial stiffness, carotid intima media thickness, and serum measures of cardiometabolic risk and inflammation. We provide resources for SEED researchers to integrate these methods into projects or to better understand these methods when reading the literature as well as where to find collaborators for more in-depth studies incorporating these measures. With broader integration of psychological and physical health measures in SEED research, we can better inform theory and interventions to promote health and resilience in individuals who have experienced early stress.
C1 [Doom, Jenalee R.] Univ Denver, Dept Psychol, Denver, CO 80208 USA.
   [Reid, Brie M.] Univ Minnesota, Inst Child Dev, 51 E River Rd, Minneapolis, MN 55455 USA.
   [Nagel, Emily] Univ Minnesota, Dept Food Sci & Nutr, Minneapolis, MN 55455 USA.
   [Gahagan, Sheila] Univ Calif San Diego, Dept Pediat, San Diego, CA 92103 USA.
   [Demerath, Ellen W.] Univ Minnesota, Sch Publ Hlth, Div Epidemiol & Community Hlth, Minneapolis, MN USA.
   [Lumeng, Julie C.] Univ Michigan, Dept Pediat, Ctr Human Growth & Dev, Ann Arbor, MI 48109 USA.
C3 University of Denver; University of Minnesota System; University of
   Minnesota Twin Cities; University of Minnesota System; University of
   Minnesota Twin Cities; University of California System; University of
   California San Diego; University of Minnesota System; University of
   Minnesota Twin Cities; University of Michigan System; University of
   Michigan
RP Doom, JR (corresponding author), Univ Denver, Dept Psychol, Denver, CO 80208 USA.
EM jena.doom@du.edu
RI Reid, Brie/ABC-9782-2020
OI Nagel, Emily/0000-0002-5792-009X; Doom, Jenalee/0000-0003-2857-0817;
   Demerath, Ellen/0000-0002-4585-4064
FU NSF [00039202, R01HD080444, R01HD084163];  [K01HL143159]; 
   [F32HD088029]; Eunice Kennedy Shriver National Institute of Child Health
   and Human Development [R01HD084163] Funding Source: NIH RePORTER;
   National Institute of Diabetes and Digestive and Kidney Diseases
   [P30DK020572] Funding Source: NIH RePORTER
FX We thank the following funding sources for support while writing this
   review: K01HL143159 (PI: Doom), F32HD088029 (PI: Doom), NSF Graduate
   Research Fellowship Program No. 00039202 (PI: Reid), R01HD080444 (PI:
   Demerath), and R01HD084163 (PI: Lumeng).
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   2006, DEV OR HLTH DIS, P1
NR 227
TC 5
Z9 5
U1 0
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0012-1630
EI 1098-2302
J9 DEV PSYCHOBIOL
JI Dev. Psychobiol.
PD MAY
PY 2021
VL 63
IS 4
BP 593
EP 621
DI 10.1002/dev.22032
EA SEP 2020
PG 29
WC Developmental Biology; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Developmental Biology; Psychology
GA SM2ZV
UT WOS:000567435800001
PM 32901949
OA Green Accepted, Green Published
DA 2025-06-11
ER

PT J
AU Chandra, NC
AF Chandra, Nimai C.
TI A comprehensive account of insulin and LDL receptor activity over the
   years: A highlight on their signaling and functional role
SO JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
LA English
DT Review
DE atherosclerosis; diabetes; insulin receptor; LDL receptor; receptor
   signaling
ID LOW-DENSITY-LIPOPROTEIN; VISCERAL ADIPOSE-TISSUE; METABOLIC SYNDROME;
   ENDOTHELIAL DYSFUNCTION; CARDIOVASCULAR-DISEASE; SERUM-CHOLESTEROL;
   OXIDATIVE STRESS; PLASMA-MEMBRANE; MESSENGER-RNA; RISK-FACTORS
AB Insulin receptor (IR) was discovered in 1970. Shortcomings in IR transcribed signals were found pro-diabetic, which could also inter-relate obesity and atherosclerosis in a time-dependent manner. Low-density lipoprotein receptor (LDLR) was discovered in 1974. Later studies showed that insulin could modulate LDLR expression and activity. Repression of LDLR transcription in the absence or inactivity of insulin showed a direct cause of atherosclerosis. Leptin receptor (OB-R) was found in 1995 and its resistance became responsible for developing obesity. The three interlinked pathologies namely, diabetes, atherosclerosis, and obesity were later on marked as metabolic syndrome-X (MSX). In 2012, the IR-LDLR inter-association was identified. In 2019, the proficiency of signal transmission from this IR-LDLR receptor complex was reported. LDLR was found to mimic IR-generated signaling path when it remains bound to IR in IR-DLR interlocked state. This was the first time LDLR was found sending messages besides its LDL-clearing activity from blood vessels.
C1 [Chandra, Nimai C.] All India Inst Med Sci, Dept Biochem, Patna 801507, Bihar, India.
C3 All India Institute of Medical Sciences (AIIMS) Patna
RP Chandra, NC (corresponding author), All India Inst Med Sci, Dept Biochem, Patna 801507, Bihar, India.
EM nc1_chandra@hotmail.com
OI Chandra, Nimai Chand/0000-0001-7580-6998
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NR 120
TC 10
Z9 11
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1095-6670
EI 1099-0461
J9 J BIOCHEM MOL TOXIC
JI J. Biochem. Mol. Toxicol.
PD SEP
PY 2021
VL 35
IS 9
AR e22840
DI 10.1002/jbt.22840
EA JUL 2021
PG 12
WC Biochemistry & Molecular Biology; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Toxicology
GA UQ0FH
UT WOS:000669837800001
PM 34227185
DA 2025-06-11
ER

PT J
AU Renna, NF
   Vazquez, MA
   Lama, MC
   González, ES
   Miatello, RM
AF Renna, Nicolas F.
   Vazquez, Marcela A.
   Lama, Maria C.
   Gonzalez, Elsa S.
   Miatello, Roberto M.
TI EFFECT OF CHRONIC ASPIRIN ADMINISTRATION ON AN EXPERIMENTAL MODEL OF
   METABOLIC SYNDROME
SO CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
LA English
DT Article
DE aspirin; fructose-fed rats; hypertension; metabolic syndrome; oxidative
   stress; vascular remodelling
ID MUSCLE-CELL-PROLIFERATION; OXIDATIVE STRESS; INSULIN-RESISTANCE;
   CARDIOVASCULAR CHANGES; ACETYLSALICYLIC-ACID; ANGIOTENSIN-II;
   HYPERTENSION; FRUCTOSE; MECHANISMS; PREVENTION
AB The aim of the present study was to examine the effect of chronic administration of aspirin on metabolic and cardiovascular parameters in fructose-fed rats (FFR), an experimental model of metabolic syndrome.
   Chronic treatment of FFR with aspirin (10 mg/kg per day for 6 weeks) partially reversed the increment in systolic blood pressure. In addition, chronic aspirin treatment normalized relative heart weight and vascular remodelling of renal and carotid arteries, measured as lumen diameter : medial thickness ratio.
   Furthermore, chronic aspirin administration completely reversed glucose intolerance and decreased the oxidative status that characterizes the FFR model, as indicated by decreased plasma levels of thiobarbituric acid-reactive substances and aortic NAD(P)H oxidase activity.
   Prevention of oxidative stress and vascular remodelling in FFR may contribute to the protective actions attributed to aspirin in the treatment of metabolic syndrome.
C1 [Miatello, Roberto M.] Univ Nacl Cuyo, Fac Ciencias Med, Ctr Univ, Sch Med,Dept Pathol, RA-5500 Mendoza, Argentina.
   CNR, Inst Expt Med & Biol Cuyo, Mendoza, Argentina.
C3 University Nacional Cuyo Mendoza
RP Miatello, RM (corresponding author), Univ Nacl Cuyo, Fac Ciencias Med, Ctr Univ, Sch Med,Dept Pathol, Av Libertador 80, RA-5500 Mendoza, Argentina.
EM rmiatell@fcm.uncu.edu.ar
FU 'Florencio Fiorini' Foundation, Argentina,; SECTyP Universidad Nacional
   de Cuyo; CONICET [PIP-5192]
FX The authors acknowledge Mrs Valeria Cacciamani for her technical
   assistance. This study was supported by grants from 'Florencio Fiorini'
   Foundation, Argentina, SECTyP Universidad Nacional de Cuyo and PIP-5192
   CONICET.
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NR 44
TC 27
Z9 29
U1 0
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0305-1870
EI 1440-1681
J9 CLIN EXP PHARMACOL P
JI Clin. Exp. Pharmacol. Physiol.
PD FEB
PY 2009
VL 36
IS 2
BP 162
EP 168
DI 10.1111/j.1440-1681.2008.05042.x
PG 7
WC Pharmacology & Pharmacy; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Physiology
GA 399VH
UT WOS:000262826900006
PM 18785983
OA Green Published
DA 2025-06-11
ER

PT J
AU Soltaninejad, M
   Yarmohammadi, H
   Madrese, E
   Khaleghi, S
   Poursadeqiyan, M
   Aminizadeh, M
   Saberinia, A
AF Soltaninejad, Mohammadreza
   Yarmohammadi, Hamed
   Madrese, Elham
   Khaleghi, Saeed
   Poursadeqiyan, Mohsen
   Aminizadeh, Mohsen
   Saberinia, Amin
TI The prevalence of metabolic syndrome in drivers: A meta-analysis and
   systematic review
SO WORK-A JOURNAL OF PREVENTION ASSESSMENT & REHABILITATION
LA English
DT Review
DE Metabolic syndrome; driver; meta-analysis; systematic review
ID TRUCK DRIVERS; SLEEP; WORK; RISK; POPULATION; DISEASE; HEALTH
AB BACKGROUND: Metabolic syndrome is an increasing disorder, especially in night workers. Drivers are considered to work during 24 hours a day. Because of job characteristics such as stress, low mobility and long working hours, they are at risk of a metabolic syndrome disorder.
   OBJECTIVES: The purpose of this study is a meta-analysis and systematic review of the prevalence of metabolic syndrome in drivers.
   METHODS: In this systematic review, articles were extracted from national and international databases: Scientific Information Database (SID), Iran Medex, Mag Iran, Google Scholar, Science Direct, PubMed, ProQuest, and Scopus. Data analysis was performed using meta-analysis and systematic review (random effect model). The calculation of heterogeneity was carried out using the 12 index and Cochran's Q test. All statistical analyses were performed using STATA software version 11.
   RESULTS: A total of nine articles related to the prevalence of metabolic syndrome in drivers in different regions of the world from 2008 to 2016 were obtained. The total sample size studied was 26156 with an average of 2906 samples per study. The prevalence of metabolic syndrome in drivers was 34% (95% CI: 30-37).
   CONCLUSION: According to the results of this study, the prevalence of metabolic syndrome in drivers is high. Occupational stress, unhealthy diet and physical inactivity cannot be cited as causes of metabolic syndrome prevalence in drivers. Therefore, to maintain and to improve the health of this group, the implementation of preventive, therapeutic and rehabilitation measures for these people as well as training should be considered.
C1 [Soltaninejad, Mohammadreza] Univ Tehran Med Sci, Roozbeh Hosp, Dept Clin Psychol, Tehran, Iran.
   [Soltaninejad, Mohammadreza] Univ Tehran Med Sci, Roozbeh Hosp, Dept Psychiat, Tehran, Iran.
   [Soltaninejad, Mohammadreza] Iran Univ Med Sci, Rajaie Cardiovasc Med & Res Ctr, Tehran, Iran.
   [Yarmohammadi, Hamed] Kermanshah Univ Med Sci, Res Ctr Environm Determinants Hlth RCEDH, Hlth Inst, Kermanshah, Iran.
   [Madrese, Elham] Univ Tehran Med Sci, Sch Publ Hlth, Dept Epidemiol & Biostat, Tehran, Iran.
   [Khaleghi, Saeed] Alborz Univ Med Sci, Dept Nursing, Karaj, Iran.
   [Poursadeqiyan, Mohsen] Torbat Heydariyeh Univ Med Sci, Dept Occupat Hlth Engn, Torbat Heydariyeh, Iran.
   [Poursadeqiyan, Mohsen] Torbat Heydariyeh Univ Med Sci, Hlth Sci Res Ctr, Sch Hlth, Torbat Heydariyeh, Iran.
   [Aminizadeh, Mohsen] Kerman Univ Med Sci, Hlth Emergency & Disaster Res Ctr, Kerman, Iran.
   [Aminizadeh, Mohsen] Univ Social Welf & Rehabil Sci, Hlth Emergency & Disaster Res Ctr, Tehran, Iran.
   [Saberinia, Amin] Shahid Beheshti Univ Med Sci, Sch Med, Dept Emergency Med, Tehran, Iran.
C3 Tehran University of Medical Sciences; Roozbeh Hospital; Tehran
   University of Medical Sciences; Roozbeh Hospital; Iran University of
   Medical Sciences; Kermanshah University of Medical Sciences; Tehran
   University of Medical Sciences; Alborz University of Medical Sciences;
   Kerman University of Medical Sciences; Shahid Beheshti University
   Medical Sciences
RP Yarmohammadi, H (corresponding author), Kermanshah Univ Med Sci, Res Ctr Environm Determinants Hlth RCEDH, Hlth Inst, Kermanshah, Iran.; Saberinia, A (corresponding author), Shahid Beheshti Univ Med Sci, Sch Med, Dept Emergency Med, Tehran, Iran.
EM Yarmohammadi68@yahoo.com; amin.saberinia@gmail.com
RI Soltaninejad, Mohammadreza/AAA-2261-2019; aminizadeh,
   mohsen/AAJ-9215-2021; Poursadeghiyan, Mohsen/P-7883-2016; Saberinia,
   Amin/AAH-9948-2021; Madreseh, Elham/AAF-4114-2021; yarmohamad,
   Fateme/JGM-7195-2023
OI Soltaninejad, Mohammadreza/0009-0006-5789-350X; Saberinia,
   Amin/0000-0001-8612-4319
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NR 33
TC 6
Z9 6
U1 0
U2 6
PU IOS PRESS
PI AMSTERDAM
PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS
SN 1051-9815
EI 1875-9270
J9 WORK
JI Work
PY 2020
VL 67
IS 4
BP 829
EP 835
DI 10.3233/WOR-203335
PG 7
WC Public, Environmental & Occupational Health
WE Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA PK9XT
UT WOS:000602788900011
PM 33325431
DA 2025-06-11
ER

PT J
AU Barman, I
   Barman, K
   Purohit, MM
   Choudhury, M
   Choudhury, AK
   Choudhury, MK
AF Barman, Indrani
   Barman, Karuna
   Purohit, Mamta Mishra
   Choudhury, Murchana
   Choudhury, Abani Kumar
   Choudhury, Monjoy Kumar
TI A study of mental stress and antioxidant profile in the
   Assamese-speaking diabetic population of Assam, India
SO INTERNATIONAL JOURNAL OF DIABETES IN DEVELOPING COUNTRIES
LA English
DT Article
DE Anxiety; Antioxidant; Diabetes; Stress
ID METABOLIC SYNDROME; MELLITUS
AB The aim of this study is to compare the biochemical stress in persons with diabetes and their anxiety level (mental stress). Normal volunteers and persons with diabetes of either sex between the age of 35 and 55 years were selected for the present study. They were divided into four groups (n=30). Groups I and III consisted of normal male and female volunteers without diabetes, while groups II and IV consisted of males and females patients with diabetes, respectively. All participants reported early morning to the testing centres, and their blood samples withdrawn to check fasting blood sugar levels (FBS), lipid profile and serum antioxidant entities, respectively. Simultaneously, they were subjected to psychological testing. Their physical parameters were also analysed. The results were analysed using ANOVA. The blood sugar, lipid profile, malondialdehyde (MDA) and anxiety levels of male and female patients with diabetes (groups II and IV) were significantly higher than male and female subjects without diabetes (groups I and III). The postprandial sugar levels and glycosylated haemoglobin (HB1Ac) in females with diabetes were significantly higher than males with diabetes. The serum antioxidant levels in groups II and IV were significantly reduced than in groups I and III. The study concludes that people with diabetes has elevated lipid and reduced serum antioxidant profiles. The anxiety levels in them were also higher, but the anxieties of males with diabetes were significantly higher than females with diabetes.
C1 [Barman, Indrani; Choudhury, Monjoy Kumar] Univ Sci & Technol Meghalaya, Dept Biochem, Ri Bhoi, Meghalaya, India.
   [Barman, Karuna] Barman Diabet Special, Gauhati, Assam, India.
   [Choudhury, Murchana] Govt Ayurved Coll, Gauhati, Assam, India.
   [Choudhury, Murchana] Univ Sci & Technol Meghalaya, Dept Psychol, Ri Bhoi, Meghalaya, India.
   [Choudhury, Abani Kumar] Choudhury Clin, Tangla, Assam, India.
EM monjoy_ch@yahoo.com
FU University of Science and Technology, Meghalaya
FX The authors would like to acknowledge the Vice chancellor of University
   of Science and Technology, Meghalaya Dr. Satyandra Kumar Choudhury and
   the Registrar Dr. C.R. Sarkar for providing the funds and space required
   for the completion of the study. We would also like to acknowledge Ms.
   Pallavi Baruah for editing the manuscript.
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NR 38
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER INDIA
PI NEW DELHI
PA 7TH FLOOR, VIJAYA BUILDING, 17, BARAKHAMBA ROAD, NEW DELHI, 110 001,
   INDIA
SN 0973-3930
EI 1998-3832
J9 INT J DIABETES DEV C
JI Int. Diabetes Dev. Ctries.
PD SEP
PY 2015
VL 35
SU 2
BP S163
EP S172
DI 10.1007/s13410-015-0313-4
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA CY6OP
UT WOS:000366529000014
DA 2025-06-11
ER

PT J
AU Culha, MG
   Tuken, M
   Gonultas, S
   Cakir, OO
   Serefoglu, EC
AF Culha, Mehmet Gokhan
   Tuken, Murat
   Gonultas, Serkan
   Cakir, Omer Onur
   Serefoglu, Ege Can
TI Frequency of etiological factors among patients with acquired premature
   ejaculation: prospective, observational, single-center study
SO INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH
LA English
DT Article
ID PROSTATITIS SYMPTOM INDEX; AD HOC COMMITTEE; INTERNATIONAL SOCIETY;
   NATIONAL-INSTITUTES; METABOLIC SYNDROME; ERECTILE FUNCTION; TURKISH
   SOCIETY; SEXUAL SYMPTOMS; LATENCY TIME; PREVALENCE
AB Although premature ejaculation (PE) is a common male sexual dysfunction, its pathophysiology has not been fully elucidated. Several medical problems such as erectile dysfunction, depression, anxiety, hormonal disorders and chronic prostatitis may play a role in the etiology of acquired PE. This study aims to evaluate the frequency of these etiologic factors among patients with acquired PE. Between May and July 2016, 53 men with acquired PE were included in the study. Self-estimated intravaginal ejaculation latency time (IELT) of these patients was recorded along with their medical history and physical examination findings. Moreover, 5-item version of the International Index of Erectile Function (IIEF-5), premature ejaculation profile (PEP), anxiety and depression scales (STAI-1, STAI-2, and BECK), and chronic prostatitis symptom index (NIH-CPSI) were administered. Fasting plasma glucose, follicle stimulating hormone (FSH), luteinizing hormone (LH), prolactin, total and free testosterone, total prostate specific antigen, thyroid and thyroid stimulating hormone levels were measured. Urine analysis and 2 cup tests were also studied. Mean age of the patients was 42.41 +/- 11.14 (22-60). Mean duration of the PE complaint was 34.18 +/- 36.76 (3-144) months. Mean IELT time of the patients was 38.28 +/- 30.79 (3-180) s. Of the patients; 69.81%, 62.26%, 56.60%, 45.28%, 30.19%, 24.53%, 16.98%, 15.09%, and 7.55% had depression, chronic prostatitis, erectile dysfunction, anxiety, diabetes mellitus, abnormal FSH or LH, hypoprolactinemia, hyperthyroidism, and high testosterone levels, respectively. The results of our study revealed that anxiety disorders, depression, erectile dysfunction, and chronic prostatitis are common among patients with acquired PE and may play role in the etiology of this problem. There is a need for further researches related to the exact pathophysiology of acquired PE with larger number of patients.
C1 [Culha, Mehmet Gokhan] Univ Hlth Sci, Okmeydani Training & Res Hosp, Dept Urol, Istanbul, Turkey.
   [Tuken, Murat] Univ Hlth Sci, Dept Urol, Bakirkoy Dr Sadi Konuk Training & Res Hosp, Istanbul, Turkey.
   [Gonultas, Serkan] Gaziosmanpasa Taksim Training & Res Hosp, Dept Urol, Istanbul, Turkey.
   [Cakir, Omer Onur] Bagcilar Training & Res Hosp, Dept Urol, Istanbul, Turkey.
   [Serefoglu, Ege Can] Bahceci Hlth Grp, Dept Urol, Istanbul, Turkey.
C3 University of Health Sciences Turkey; Istanbul Okmeydani Training &
   Research Hospital; Bakirkoy Dr. Sadi Konuk Research & Training Hospital;
   University of Health Sciences Turkey; Istanbul Gaziosmanpasa Taksim
   Training & Research Hospital; Istanbul Bagcilar Training & Research
   Hospital
RP Serefoglu, EC (corresponding author), Bahceci Hlth Grp, Dept Urol, Istanbul, Turkey.
EM egecanserefoglu@hotmail.com
RI , gokhanculha/AAL-8393-2020; Gönültaş, Serkan/K-7491-2018; Serefoglu,
   Ege/H-4135-2019; Cakir, Omer Onur/D-7375-2017; tüken,
   murat/AAZ-1883-2020
OI Cakir, Omer Onur/0000-0001-7499-7227; Gonultas,
   Serkan/0000-0001-6556-7751
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NR 52
TC 33
Z9 34
U1 0
U2 3
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0955-9930
EI 1476-5489
J9 INT J IMPOT RES
JI Int. J. Impot. Res.
PD MAY
PY 2020
VL 32
IS 3
BP 352
EP 357
DI 10.1038/s41443-019-0188-x
PG 6
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Urology & Nephrology
GA LO5OG
UT WOS:000533676400015
PM 31477853
DA 2025-06-11
ER

PT J
AU Steinberg, BA
   Cannon, CP
AF Steinberg, Benjamin A.
   Cannon, Christopher P.
TI Cannabinoid-1 receptor blockade in cardiometabolic risk reduction:
   Safety, tolerability, and therapeutic potential
SO AMERICAN JOURNAL OF CARDIOLOGY
LA English
DT Article
ID ENDOGENOUS CANNABINOIDS; OVERWEIGHT PATIENTS; CB1 RECEPTORS; RIMONABANT;
   WEIGHT; EXPRESSION; MORTALITY; MEDIATE
AB Rimonabant is the first selective blocker of the cannabinoid-1 receptor in development for the treatment of obesity, diabetes mellitus, and cardiometabolic risk factors. (Recently, an FDA Advisory Committee recommended a delay in the approval of rimonabant because of safety issues that need to be addressed in further studies.) Although it is associated with favorable effects on weight, waist circumference, serum lipids, C-reactive protein, and an improvement in glycemic control in type 2 diabetes, there are concerns about side effects. Generally, rimonabant has been well tolerated, with a primary side effect of nausea. Other side effects seen in trials have been anxiety and depressive symptoms, as well as neurologic events, albeit at low rates. When rimonabant becomes clinically available, physicians should be vigilant regarding the expected side effects and use alternative therapies if needed. (c) 2007 Elsevier Inc. All rights reserved.
C1 [Cannon, Christopher P.] Brigham & Womens Hosp, Thrombolysis Myocardial Infarct TIMI Study, Dept Med, Div Cardiovasc, Boston, MA 02115 USA.
   [Steinberg, Benjamin A.] Johns Hopkins Univ Hosp, Dept Med, Baltimore, MD 21287 USA.
   [Cannon, Christopher P.] Harvard Univ, Sch Med, Boston, MA USA.
C3 Harvard University; Harvard University Medical Affiliates; Brigham &
   Women's Hospital; Johns Hopkins University; Johns Hopkins Medicine;
   Harvard University; Harvard Medical School
RP Cannon, CP (corresponding author), Brigham & Womens Hosp, Thrombolysis Myocardial Infarct TIMI Study, Dept Med, Div Cardiovasc, 1st Floor,350 Longwood Ave, Boston, MA 02115 USA.
EM cpcannon@partners.org
RI Cannon, Christopher/AAY-7644-2020
OI Steinberg, Benjamin/0000-0002-4729-7820
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   COMPREHENSIVE RIMONB
   STRATEGY REDUCE ATHE
NR 27
TC 23
Z9 26
U1 0
U2 1
PU EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
PI BRIDGEWATER
PA 685 ROUTE 202-206 STE 3, BRIDGEWATER, NJ 08807 USA
SN 0002-9149
EI 1879-1913
J9 AM J CARDIOL
JI Am. J. Cardiol.
PD DEC 17
PY 2007
VL 100
IS 12A
SU S
BP 27P
EP 32P
DI 10.1016/.j.amjcard.2007.10.011
PG 6
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 249FF
UT WOS:000252212200005
PM 18154743
DA 2025-06-11
ER

PT J
AU Lima, R
   Wofford, M
   Reckelhoff, JF
AF Lima, Roberta
   Wofford, Marion
   Reckelhoff, Jane F.
TI Hypertension in Postmenopausal Women
SO CURRENT HYPERTENSION REPORTS
LA English
DT Article
DE Menopause; Hypertension; Women; Aging; Obesity; Metabolic syndrome;
   Sympathetic nervous system; Renin-angiotensin system; Endothelin;
   Androgens; Estrogen; Depression; Cardiovascular disease; Blood pressure;
   Hormone replacement therapy
ID AMBULATORY BLOOD-PRESSURE; CARDIOVASCULAR-DISEASE RISK; HORMONE
   REPLACEMENT THERAPY; II-INDUCED HYPERTENSION; METABOLIC SYNDROME;
   OXIDATIVE STRESS; MESSENGER-RNA; SEX-HORMONES; ENDOTHELIAL DYSFUNCTION;
   ABDOMINAL OBESITY
AB Blood pressure is typically lower in premenopausal women than in men. However, after menopause, the prevalence of hypertension in women is higher than it is in men. Hypertension is a major risk factor for cardiovascular disease in women and men, but cardiovascular disease is the leading cause of death in women. Furthermore, there is evidence that blood pressure may not be as well-controlled in women as in men, despite the fact that most women adhere better to their therapeutic regimens and medications than do men, and have their blood pressures measured more frequently than do men. This review describes possible mechanisms by which blood pressure may be increased in postmenopausal women.
C1 [Lima, Roberta; Wofford, Marion; Reckelhoff, Jane F.] Univ Mississippi, Med Ctr, Dept Physiol & Biophys, Jackson, MS 39216 USA.
C3 University of Mississippi Medical Center; University of Mississippi
RP Reckelhoff, JF (corresponding author), Univ Mississippi, Med Ctr, Dept Physiol & Biophys, 2500 N State St, Jackson, MS 39216 USA.
EM beta.lima18@gmail.com; mwofford@umc.edu; jreckelhoff@umc.edu
FU National Institutes of Health [RO1s HL66072, HL69194, PO1 HL51971]
FX The authors acknowledge the support of National Institutes of Health
   grants RO1s HL66072 and HL69194 and PO1 HL51971 (to Dr. Reckelhoff).
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NR 94
TC 166
Z9 181
U1 0
U2 12
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1522-6417
EI 1534-3111
J9 CURR HYPERTENS REP
JI Curr. Hypertens. Rep.
PD JUN
PY 2012
VL 14
IS 3
BP 254
EP 260
DI 10.1007/s11906-012-0260-0
PG 7
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 953GM
UT WOS:000304855000009
PM 22427070
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Marijnissen, RM
   Vogelzangs, N
   Mulder, ME
   van den Brink, RHS
   Comijs, HC
   Voshaar, RCO
AF Marijnissen, R. M.
   Vogelzangs, N.
   Mulder, M. E.
   van den Brink, R. H. S.
   Comijs, H. C.
   Voshaar, R. C. Oude
TI Metabolic dysregulation and late-life depression: a prospective study
SO PSYCHOLOGICAL MEDICINE
LA English
DT Article
DE Abdominal obesity; depression; elderly; metabolic syndrome; waist
   circumference
ID OLDER-ADULTS; WAIST CIRCUMFERENCE; SYMPTOM PROFILES; BLOOD-PRESSURE;
   2-YEAR COURSE; OBESITY; ASSOCIATION; NETHERLANDS; COMMUNITY; DISORDER
AB Background. Depression is associated with the metabolic syndrome (MS). We examined whether metabolic dysregulation predicted the 2-year course of clinical depression.
   Method. A total of 285 older persons (>= 60 years) suffering from depressive disorder according to DSM-IV-TR criteria was followed up for 2 years. Severity of depression was assessed with the Inventory of Depressive Symptomatology (IDS) at 6-month intervals. Metabolic syndrome was defined according the National Cholesterol Education Programme (NCEP-ATP III). We applied logistic regression and linear mixed models adjusted for age, sex, years of education, smoking, alcohol use, physical activity, somatic co-morbidity, cognitive functioning and drug use (antidepressants, anti-inflammatory drugs) and severity of depression at baseline.
   Results. MS predicted non-remission at 2 years (odds ratio(per component) = 1.26, 95% confidence interval 1.00-1.58), p = 0.047), which was driven by the waist circumference and HDL cholesterol. MS was not associated with IDS sum score. Subsequent analyses on its subscales, however, identified an association with the somatic symptom subscale score over time (interaction time x somatic subscale, p = 0.005), driven by higher waist circumference and elevated fasting glucose level.
   Conclusions. Metabolic dysregulation predicts a poor course of late-life depression. This finding supports the concept of 'metabolic depression', recently proposed on population-based findings of a protracted course of depressive symptoms in the presence of metabolic dysregulation. Our findings seem to be driven by abdominal obesity (as indicated by the waist circumference) and HDL cholesterol dysregulation.
C1 [Marijnissen, R. M.; Mulder, M. E.] ProPersona, Dept Old Age Psychiat, Arnhem, Netherlands.
   [Marijnissen, R. M.; van den Brink, R. H. S.; Voshaar, R. C. Oude] Univ Groningen, Univ Med Ctr Groningen, Univ Ctr Psychiat, Groningen, Netherlands.
   [Marijnissen, R. M.; van den Brink, R. H. S.; Voshaar, R. C. Oude] Univ Groningen, Univ Med Ctr Groningen, Interdisciplinary Ctr Psychopathol Emot Regulat, Groningen, Netherlands.
   [Vogelzangs, N.] Maastricht Univ, Dept Epidemiol, Cardiovasc Res Inst Maastricht CARIM, Maastricht, Netherlands.
   [Vogelzangs, N.] Maastricht Univ, Maastricht Ctr Syst Biol MaCSBio, Maastricht, Netherlands.
   [Comijs, H. C.] Vrije Univ Amsterdam, Med Ctr, GGZinGeest, Dept Psychiat,EMGO Inst Hlth & Care Res, Amsterdam, Netherlands.
C3 University of Groningen; University of Groningen; Maastricht University;
   Maastricht University; Vrije Universiteit Amsterdam
RP Marijnissen, RM (corresponding author), ProPersona, Dept Old Age Psychiat, Wolfheze 2, NL-6874 BE Wolfheze, Netherlands.
EM r.marijnissen@propersona.nl
OI Oude Voshaar, Richard/0000-0003-1501-4774
FU Fonds NutsOhra; Stichting tot Steun VCVGZ; NARSAD The Brain and
   Behaviour Research Fund; VU University Medical Center; Leiden University
   Medical Center; University Medical Center Groningen; Radboud University
   Nijmegen Medical Center; GGZ inGeest; GGNet; GGZ Nijmegen; GGZ
   Rivierduinen; Lentis; Parnassia; Dutch Scientific Organisaton (ZonMW)
   [90700231]
FX The infrastructure for NESDO is funded through the Fonds NutsOhra,
   Stichting tot Steun VCVGZ, NARSAD The Brain and Behaviour Research Fund,
   and the participating universities and mental healthcare organizations
   (VU University Medical Center, Leiden University Medical Center,
   University Medical Center Groningen, Radboud University Nijmegen Medical
   Center, and GGZ inGeest, GGNet, GGZ Nijmegen, GGZ Rivierduinen, Lentis,
   and Parnassia). R. C. Oude Voshaar is research fellow of the Dutch
   Scientific Organisaton (ZonMW) (research grant 90700231).
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NR 66
TC 45
Z9 45
U1 0
U2 14
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
SN 0033-2917
EI 1469-8978
J9 PSYCHOL MED
JI Psychol. Med.
PD APR
PY 2017
VL 47
IS 6
BP 1041
EP 1052
DI 10.1017/S0033291716003196
PG 12
WC Psychology, Clinical; Psychiatry; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA EN9FL
UT WOS:000396306000006
PM 27938429
DA 2025-06-11
ER

PT J
AU Mittra, S
   Bansal, VS
   Bhatnagar, PK
AF Mittra, Shivani
   Bansal, Vinay S.
   Bhatnagar, Pradip K.
TI From a glucocentric to a lipocentric approach towards metabolic syndrome
SO DRUG DISCOVERY TODAY
LA English
DT Review
ID ENDOPLASMIC-RETICULUM STRESS; MUSCLE GLUCOSE-TRANSPORT;
   INSULIN-RESISTANCE; ADIPOSE-TISSUE; FATTY-ACIDS; OXIDATIVE STRESS;
   OBESITY; MECHANISM; PHOSPHORYLATION; INFLAMMATION
AB Insulin resistance, the essential component of metabolic syndrome, has traditionally been defined from a glucocentric viewpoint, with glucotoxicity playing a lead role. However, as overabundant circulating fatty acids are now known to be overt contributors, there is a paradigm shift in the understanding of metabolic syndrome acknowledging the importance of lipotoxicity as a major perpetuator of insulin resistance. Ectopic accumulation of fat in liver, adipose, muscle and pancreatic islets, provokes insulin resistance through various mechanisms. Chronic inflammation/adipocytokine generation, endoplasmic reticulum stress and mitochondrial dysfunction/oxidative stress also contribute significantly towards insulin resistance. Targets that can act as counter regulators/master switches at the converging point of all these metabolic pathways are currently under intense development.
C1 [Mittra, Shivani; Bansal, Vinay S.; Bhatnagar, Pradip K.] Ranbaxy Res Labs, Dept Pharmacol, Udyog Vihar Ind Area, Gurgaon 122001, Haryana, India.
RP Mittra, S (corresponding author), Ranbaxy Res Labs, Dept Pharmacol, Udyog Vihar Ind Area, R&D 3,Plot 20,Sector 18, Gurgaon 122001, Haryana, India.
EM shivani.mittra@ranbaxy.com
OI Mittra, Shivani/0000-0002-5488-7140
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NR 75
TC 31
Z9 39
U1 0
U2 2
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1359-6446
EI 1878-5832
J9 DRUG DISCOV TODAY
JI Drug Discov. Today
PD MAR
PY 2008
VL 13
IS 5-6
BP 211
EP 218
DI 10.1016/j.drudis.2008.01.006
PG 8
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 283UL
UT WOS:000254661900004
PM 18342796
DA 2025-06-11
ER

PT J
AU Patil, AD
   Vaidya, RA
   Begum, S
   Chauhan, SL
   Mukherjee, S
   Kokate, PP
   Joshi, BN
AF Patil, Anushree Devashish
   Vaidya, Rama Ashok
   Begum, Shahina
   Chauhan, Sanjay L.
   Mukherjee, Srabani
   Kokate, Pratibha P.
   Joshi, Beena Nitin
TI An integrated multidisciplinary model of care for addressing
   comorbidities beyond reproductive health among women with polycystic
   ovary syndrome in India
SO INDIAN JOURNAL OF MEDICAL RESEARCH
LA English
DT Article
DE Comorbidities; integrated; metabolic syndrome; multidisciplinary model;
   polycystic ovary syndrome
ID METABOLIC SYNDROME; PREVALENCE; DIAGNOSIS; MANAGEMENT
AB Background & objectives:Polycystic Ovary Syndrome (PCOS) is becoming an area of global and national health concern. It requires a life cycle approach from adolescence to menopause. To comprehensively address the wide spectrum of this disorder, a multidisciplinary model of care was established for women with PCOS in a government setting in India with an objective to screen and manage multifaceted manifestations of PCOS and to diagnose and treat associated comorbidities such as metabolic syndrome, dermatologic manifestations and psychological issues.Methods:A model of integrated multidisciplinary PCOS clinic was implemented for services and research at ICMR-National Institute for Research in Reproductive and Child Health (NIRRCH), Mumbai Maharashtra, India. This is a one-stop holistic centre for managing menstrual, cosmetic, infertility, obesity, metabolic and psychological concerns of women affected with PCOS. Two hundred and twenty six women diagnosed with PCOS using the Rotterdam criteria were screened for metabolic comorbidities with anthropometry, ultrasonography, hormonal and biochemical tests and for psychological problems. Analysis was performed using SPSS version 19.0.Results:Mean body mass index (BMI) was 26.1 kg/m2, higher for Asians. Hirsutism was observed in 53.6 per cent of women. Metabolic syndrome was seen among 35.3 per cent and non-alcoholic fatty liver in 18.3 per cent. Psychological issues such as anxiety and depression were identified in majority of the women 31.4 per cent of women could achieve pregnancy at the end of one year of multidisciplinary management.Interpretation & conclusions:The results of the present study suggest that an integrated multidisciplinary approach led to the early identification and treatment of comorbidities of PCOS, especially metabolic syndrome. There is hence an urgent need to implement multidisciplinary PCOS clinics in government health facilities.
C1 [Patil, Anushree Devashish; Kokate, Pratibha P.] ICMR Natl Inst Res Reprod & Child Hlth, Dept Clin Res, Mumbai, Maharashtra, India.
   [Begum, Shahina] ICMR Natl Inst Res Reprod & Child Hlth, Dept Biostat, Mumbai, Maharashtra, India.
   [Chauhan, Sanjay L.; Joshi, Beena Nitin] ICMR Natl Inst Res Reprod & Child Hlth, Dept Operat Res, Jehangir Merwanji St, Mumbai 400012, Maharashtra, India.
   [Mukherjee, Srabani] ICMR Natl Inst Res Reprod & Child Hlth, Dept Mol Endocrinol, Mumbai, Maharashtra, India.
   [Vaidya, Rama Ashok] Kasturba Hlth Soc, Med Res Ctr, Mumbai, Maharashtra, India.
C3 Indian Council of Medical Research (ICMR); ICMR - National Institute for
   Research in Reproductive & Child Health (NIRRCH); Indian Council of
   Medical Research (ICMR); ICMR - National Institute for Research in
   Reproductive & Child Health (NIRRCH); Indian Council of Medical Research
   (ICMR); ICMR - National Institute for Research in Reproductive & Child
   Health (NIRRCH); Indian Council of Medical Research (ICMR); ICMR -
   National Institute for Research in Reproductive & Child Health (NIRRCH)
RP Joshi, BN (corresponding author), ICMR Natl Inst Res Reprod & Child Hlth, Dept Operat Res, Jehangir Merwanji St, Mumbai 400012, Maharashtra, India.
EM joshib@nirrch.res.in
OI Chauhan, Sanjay/0009-0009-1520-0260
FU ICMR-NIRRCH, Mumbai
FX The study was supported by the intramural fund of ICMR-NIRRCH, Mumbai.
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NR 31
TC 5
Z9 5
U1 1
U2 3
PU SCIENTIFIC SCHOLAR LLC
PI PITTSFORD
PA 50, WOODGREEN DR, PITTSFORD, NY 14534 USA
SN 0971-5916
J9 INDIAN J MED RES
JI Indian J. Med. Res.
PD SEP
PY 2022
VL 156
IS 3
BP 449
EP 458
DI 10.4103/ijmr.IJMR_2497_19
PG 10
WC Immunology; Medicine, General & Internal; Medicine, Research &
   Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; General & Internal Medicine; Research & Experimental
   Medicine
GA N7T7F
UT WOS:001366320700011
PM 36588359
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Konstandi, M
   Shah, YM
   Matsubara, T
   Gonzalez, FJ
AF Konstandi, Maria
   Shah, Yatrik M.
   Matsubara, Tsutomu
   Gonzalez, Frank J.
TI Role of PPARα and HNF4α in Stress-Mediated Alterations in Lipid
   Homeostasis
SO PLOS ONE
LA English
DT Article
ID PSYCHOLOGICAL STRESS; TARGETED DISRUPTION; METABOLIC SYNDROME;
   TRIGLYCERIDE; CHOLESTEROL; RECEPTORS; OBESITY; GENE; SECRETION; ACID
AB Stress is a risk factor for several cardiovascular pathologies. PPAR alpha holds a fundamental role in control of lipid homeostasis by directly regulating genes involved in fatty acid transport and oxidation. Importantly, PPAR alpha agonists are effective in raising HDL-cholesterol and lowering triglycerides, properties that reduce the risk for cardiovascular diseases. This study investigated the role of stress and adrenergic receptor (AR)-related pathways in PPAR alpha and HNF4 alpha regulation and signaling in mice following repeated restraint stress or treatment with AR-antagonists administered prior to stress to block AR-linked pathways. Repeated restraint stress up-regulated Ppar alpha and its target genes in the liver, including Acox, Acot1, Acot4, Cyp4a10, Cyp4a14 and Lipin2, an effect that was highly correlated with Hnf4 alpha. In vitro studies using primary hepatocyte cultures treated with epinephrine or AR-agonists confirmed that hepatic AR/cAMP/PKA/CREB- and JNK-linked pathways are involved in PPAR alpha and HNF4 alpha regulation. Notably, restraint stress, independent of PPAR alpha, suppressed plasma triglyceride levels. This stress-induced effect could be attributed in part to hormone sensitive lipase activation in the white adipose tissue, which was not prevented by the increased levels of perilipin. Overall, this study identifies a mechanistic basis for the modification of lipid homeostasis following stress and potentially indicates novel roles for PPAR alpha and HNF4 alpha in stress-induced lipid metabolism.
C1 [Konstandi, Maria; Shah, Yatrik M.; Matsubara, Tsutomu; Gonzalez, Frank J.] NCI, Lab Metab, NIH, Bethesda, MD 20892 USA.
   [Konstandi, Maria] Univ Ioannina, Sch Med, Dept Pharmacol, GR-45110 Ioannina, Greece.
   [Shah, Yatrik M.] Univ Michigan, Dept Mol & Integrat Physiol, Ann Arbor, MI 48109 USA.
C3 National Institutes of Health (NIH) - USA; NIH National Cancer Institute
   (NCI); University of Ioannina; University of Michigan System; University
   of Michigan
RP Konstandi, M (corresponding author), NCI, Lab Metab, NIH, Bethesda, MD 20892 USA.
EM mkonstan@cc.uoi.gr
RI Gonzalez, Francisco/GWV-3999-2022
OI Gonzalez, Frank/0000-0002-7990-2140
FU National Cancer Institute Intramural Research Program; Molecular Life
   Science, University of Oslo; Norwegian Cancer Society [PR-2006-0442,
   PR-2007-0166]; National Institute of Diabetes and Digestive and Kidney
   Diseases [P30DK020572] Funding Source: NIH RePORTER
FX This study was supported by the National Cancer Institute Intramural
   Research Program. ML is supported as a PhD student by Molecular Life
   Science, University of Oslo and the study is supported by the Norwegian
   Cancer Society (PR-2006-0442, RAL; PR-2007-0166, RIS). The funders had
   no role in study design, data collection and analysis, decision to
   publish, or preparation of the manuscript.
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NR 71
TC 21
Z9 26
U1 1
U2 14
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD AUG 14
PY 2013
VL 8
IS 8
AR e70675
DI 10.1371/journal.pone.0070675
PG 12
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 202MQ
UT WOS:000323221500023
PM 23967086
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Miettola, J
   Niskanen, L
   Viinamäki, H
   Kumpusalo, E
AF Miettola, Juhani
   Niskanen, Leo K.
   Viinamaki, Heimo
   Kumpusalo, Esko
TI Metabolic syndrome is associated with self-perceived depression
SO SCANDINAVIAN JOURNAL OF PRIMARY HEALTH CARE
LA English
DT Article
DE Adult population; depression; family practice; fasting plasma glucose;
   metabolic syndrome; waist circumference
ID QUALITY-OF-LIFE; INSULIN-RESISTANCE; SEXUAL DYSFUNCTION; MAJOR
   DEPRESSION; YOUNG-ADULTS; POPULATION; WOMEN; OBESITY; HEALTH; COHORT
AB Objective. To study the association between metabolic syndrome (MetS) and self-perceived depression. Design. A cross-sectional community-based study. Setting. Semi-rural community of Lapinlahti in eastern Finland in 2005. Subjects. A total of 416 subjects in eight adult birth cohorts (55%) with complete Beck Depression Inventory (BDI-21) questionnaire data. Main outcome measures. The values of the 21 BDI items and the BDI-21 total score with a cut-off point of 14/15 were used to study the association between MetS and depression. National Cholesterol Education Programme (NCEP) 2005 criteria were used for MetS classification. Results. The total BDI-21 score was significantly higher in the subjects with MetS than in the subjects without MetS (p=0.020). Men with MetS were significantly worse off than men without MetS in the BDI-21 items of irritability (p=0.008), work inhibition (p=0.008), fatigability (p=0.037), weight loss (p=0.045), and loss of libido (p=0.014), while women were only so on the item of loss of libido (p=0.007). In a logistic regression analysis using a BDI-21 cut-off point of 14/15 adjusted for age, marital status, vocational education, and working status, significant association was retained between perceived depression and elevated blood glucose among men (OR=1.697) and large waist circumference among women (OR=1.066). Conclusion. Elevated plasma glucose in men and central obesity in women are associated with self-perceived depression. This co-occurrence deserves attention in clinical practice.
C1 [Miettola, Juhani; Kumpusalo, Esko] Kuopio Univ Hosp, Family Practice Unit, FIN-70211 Kuopio, Finland.
   [Niskanen, Leo K.] Kuopio Univ Hosp, Dept Med, FIN-70211 Kuopio, Finland.
   [Viinamaki, Heimo] Kuopio Univ Hosp, Dept Psychiat, FIN-70211 Kuopio, Finland.
   Univ Kuopio, FIN-70211 Kuopio, Finland.
C3 Kuopio University Hospital; Kuopio University Hospital; Kuopio
   University Hospital; University of Eastern Finland
RP Miettola, J (corresponding author), Kuopio Univ Hosp, Family Practice Unit, POB 1777, FIN-70211 Kuopio, Finland.
EM juhani.miettola@uku.fi
FU municipality of Lapinlahti; Development Programme for the Prevention and
   Care of Diabetes in Finland [DEHKO/D2D]
FX The authors would like to thank the participating Lapinlahti residents
   and the staff members of the Lapinlahti Primary Health Care Centre and
   the Kuopio University Hospital Laboratory. The study would not have been
   possible without the financial support of the municipality of Lapinlahti
   and the Development Programme for the Prevention and Care of Diabetes in
   Finland ( DEHKO/D2D) through the Northern Savo Hospital District.
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NR 33
TC 54
Z9 61
U1 0
U2 2
PU TAYLOR & FRANCIS AS
PI OSLO
PA KARL JOHANS GATE 5, NO-0154 OSLO, NORWAY
SN 0281-3432
J9 SCAND J PRIM HEALTH
JI Scand. J. Prim. Health Care
PY 2008
VL 26
IS 4
BP 203
EP 210
AR PII 793246121
DI 10.1080/02813430802117624
PG 8
WC Health Care Sciences & Services; Primary Health Care; Medicine, General
   & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services; General & Internal Medicine
GA 376NP
UT WOS:000261190600003
PM 18609254
OA Green Accepted, Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Tung, TH
   Nguyen, NTK
   Huang, SY
AF Tung, Te-Hsuan
   Nguyen, Ngan Thi Kim
   Huang, Shih-Yi
TI New Insights into Depressive Disorder with Respect to Low-Grade
   Inflammation and Fish Oil Intake
SO JOURNAL OF OLEO SCIENCE
LA English
DT Review
DE depression; low-grade inflammation; n-3 polyunsaturated fatty acids;
   fish oil
ID BLOOD-BRAIN-BARRIER; TREATMENT-RESISTANT DEPRESSION; POLYUNSATURATED
   FATTY-ACIDS; IMMUNE-SYSTEM; DOUBLE-BLIND; OMEGA-3-FATTY-ACIDS;
   METAANALYSIS; MICROGLIA; N-3; STRESS
AB Unipolar depression has been recognized as one of the major diseases by the World Health Organization in the 21st century. The etiology of depression is complicated and includes genetic factors, stress, aging, and special physical status (pregnancy, metabolic syndrome, and trauma). Numerous animal and human studies have demonstrated that n-3 polyunsaturated fatty acids (n-3 PUFAs) are highly correlated to cognition and depression. These nutritional antidepressants, including EPA and DHA, have a range of neurobiological activities contributing to their potential antidepressant effects. Our preclinical and clinical studies have indicated that n-3 PUFA supplementation in addition to standard antidepressant medications may provide synergistic neuroprotective and antioxidant/inflammatory effects. To translate our preliminary findings into clinical application, this paper reviews the existing evidence on the antidepressant effects of n-3 PUFAs and the potential underlying mechanisms, which include modulation of chronic lowgrade inflammation and the corresponding changes in peripheral blood immune biomarkers.
C1 [Tung, Te-Hsuan; Nguyen, Ngan Thi Kim; Huang, Shih-Yi] Taipei Med Univ, Sch Nutr & Hlth Sci, Taipei 110301, Taiwan.
   [Nguyen, Ngan Thi Kim] Univ Med & Pharm Ho Chi Minh City, Fac Publ Hlth, Dept Nutr & Food Sci, Ho Chi Minh City, Vietnam.
   [Huang, Shih-Yi] Taipei Med Univ, Grad Inst Metab & Obes Sci, Taipei 110301, Taiwan.
   [Huang, Shih-Yi] Taipei Med Univ Hosp, Nutr Res Ctr, Taipei 110301, Taiwan.
C3 Hochiminh City University of Medicine & Pharmacy; Taipei Medical
   University Hospital
RP Huang, SY (corresponding author), Taipei Med Univ, Sch Nutr & Hlth Sci, 250 Wu Xing St, Taipei 110, Taiwan.
EM sihuang@tmu.edu.tw
RI Nguyen, Ngan/GYJ-5263-2022; Huang, Shih-Yi/R-3495-2018; Tung,
   Te-Hsuan/KBB-9847-2024
OI Tung, Te-Hsuan/0000-0002-0712-4861; Nguyen, Ngan Thi
   Kim/0000-0002-5655-7292
FU Taiwan Ministry of Science and Technology [MOST 109-2314-B-038-007,
   109-2320-B-038-057-MY3]
FX This study was partially supported by grants from the Taiwan Ministry of
   Science and Technology [MOST 109-2314-B-038-007 &
   109-2320-B-038-057-MY3] .
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NR 98
TC 4
Z9 4
U1 1
U2 9
PU JAPAN OIL CHEMISTS SOC
PI TOKYO
PA YUSHI KOGYO KAIKAN BLDG, 13-11, NIHONBASHI 3-CHOME, CHUO-KU, TOKYO,
   103-0027, JAPAN
SN 1345-8957
EI 1347-3352
J9 J OLEO SCI
JI J. Oleo Sci.
PY 2021
VL 70
IS 11
BP 1539
EP 1550
DI 10.5650/jos.ess21209
PG 12
WC Chemistry, Applied; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Food Science & Technology
GA XK9GX
UT WOS:000727765600003
PM 34732633
OA gold
DA 2025-06-11
ER

PT J
AU Jirakran, K
   Almulla, AF
   Jaipinta, T
   Vasupanrajit, A
   Jansem, P
   Tunvirachaisakul, C
   Dzhambazova, E
   Stoyanov, DS
   Maes, M
AF Jirakran, Ketsupar
   Almulla, Abbas F.
   Jaipinta, Thapanee
   Vasupanrajit, Asara
   Jansem, Priabprat
   Tunvirachaisakul, Chavit
   Dzhambazova, Elizabet
   Stoyanov, Drozdstoj St.
   Maes, Michael
TI Increased atherogenicity in mood disorders: a systematic review,
   meta-analysis and meta-regression
SO NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
LA English
DT Review
DE Major depression; High-density cholesterol (HDL); Antioxidants;
   Oxidative stress; Metabolic syndrome; LCAT
ID MAJOR DEPRESSIVE DISORDER; SERUM-LIPID CONCENTRATIONS; POLYUNSATURATED
   FATTY-ACIDS; METABOLIC SYNDROME; CHOLESTEROL LEVELS; BIPOLAR-DISORDER;
   OXIDATIVE STRESS; ASSOCIATION; PARAMETERS; PLASMA
AB Background: Major depressive disorder (MDD) and bipolar disorder (BD) often coexist with metabolic syndrome. Both are linked to increased atherogenicity and a higher risk of cardiovascular diseases. Nevertheless, a comprehensive analysis of key atherogenic biomarkers in MDD/BD is still lacking. Objectives: This meta-analysis evaluates the relationship between atherogenic indices and MDD/BD, while identifying the most effective atherogenic biomarker. Methods: This study adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. We searched electronic databases, including PubMed, Google Scholar, and Web of Science, for articles published up to August 1, 2024. Results: We included 85 eligible studies (14 on BD and 71 on MDD), covering 70,856 participants: 18,738 patients and 52,118 healthy controls. MDD/BD patients showed significant increases (p < 0.001) in the Castelli Risk Index 2 (CRI2), Atherogenic Index of Plasma (AIP), and (triglyceride or TG + low-density lipoprotein + very low-density lipoprotein)/(high-density lipoprotein cholesterol or HDL + Apolipoprotein A or ApoA) ratio, but not CRI1 and ApoB/ApoA ratio. Significant lower HDL and lecithin: cholesterol acyltransferase activity, and higher TG levels were observed in MDD/BD patients compared with controls. There were no significant differences between MDD and BD patients. Most included studies lacked the most essential information on the inclusion and exclusion of important confounders. Conclusions: AIP is the most effective atherogenicity index for mood disorders. Regular lipid profiling and metabolic syndrome screening are crucial in MDD/BD. Early intervention with lipid-lowering therapies is recommended to prevent the worsening of atherogenicity and disease progression.
C1 [Jirakran, Ketsupar; Jaipinta, Thapanee; Vasupanrajit, Asara; Tunvirachaisakul, Chavit; Maes, Michael] Chulalongkorn Univ, Fac Med, Dept Psychiat, PhD Program Mental Hlth, Bangkok, Thailand.
   [Jirakran, Ketsupar; Almulla, Abbas F.; Jaipinta, Thapanee; Vasupanrajit, Asara; Jansem, Priabprat; Tunvirachaisakul, Chavit; Maes, Michael] Chulalongkorn Univ, King Chulalongkorn Mem Hosp, Dept Med, Bangkok, Thailand.
   [Jirakran, Ketsupar; Almulla, Abbas F.; Jaipinta, Thapanee; Vasupanrajit, Asara; Jansem, Priabprat; Tunvirachaisakul, Chavit; Maes, Michael] King Chulalongkorn Mem Hosp, Thai Red Cross Soc, Bangkok, Thailand.
   [Jirakran, Ketsupar] Chulalongkorn Univ, Fac Med, Ctr Excellence Maximizing Childrens Dev Potential, Dept Pediat, Bangkok, Thailand.
   [Almulla, Abbas F.; Maes, Michael] Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Sichuan Prov Ctr Mental Hlth, Sch Med, Chengdu 610072, Peoples R China.
   [Almulla, Abbas F.; Maes, Michael] Chinese Acad Med Sci, Key Lab Psychosomat Med, Chengdu 610072, Peoples R China.
   [Almulla, Abbas F.] Islamic Univ, Coll Med Technol, Med Lab Technol Dept, Najaf, Iraq.
   [Tunvirachaisakul, Chavit; Maes, Michael] Chulalongkorn Univ, Fac Med, Cognit Impairment & Dementia Res Unit, Bangkok, Thailand.
   [Dzhambazova, Elizabet] Med Univ Plovdiv, Fac Publ Hlth, Plovdiv, Bulgaria.
   [Stoyanov, Drozdstoj St.; Maes, Michael] Med Univ Plovdiv, Dept Psychiat, Plovdiv, Bulgaria.
   [Stoyanov, Drozdstoj St.; Maes, Michael] Med Univ Plovdiv, Res Inst, Plovdiv, Bulgaria.
   [Stoyanov, Drozdstoj St.; Maes, Michael] European Union NextGenerationEU, Res & Innovat Program Dev MU PLOVDIV SRIPD MUP, Creat Network Res Higher Sch, Natl Plan Recovery & Sustainabil, Plovdiv, Bulgaria.
   [Maes, Michael] Kyung Hee Univ, 26 Kyungheedae Ro, Seoul 02447, South Korea.
C3 Chulalongkorn University; Chulalongkorn University; Thai Red Cross
   Society; Chulalongkorn University; Chulalongkorn University; Sichuan
   Provincial People's Hospital; University of Electronic Science &
   Technology of China; Chinese Academy of Medical Sciences - Peking Union
   Medical College; Islamic University College; Chulalongkorn University;
   Medical University Plovdiv; Medical University Plovdiv; Medical
   University Plovdiv; Kyung Hee University
RP Maes, M (corresponding author), Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Sichuan Prov Ctr Mental Hlth, Sch Med, Chengdu 610072, Peoples R China.
EM thapanee.ja@up.ac.th; asara.vasu@gmail.com; psynjansem@docchula.com;
   elizabet.dzhambazova@mu-plovdiv.bg; Dr.michaelmaes@hotmail.com
RI Maes, Michael/B-8546-2011; Almulla, Abbas F./ABG-7926-2020;
   Vasupanrajit, Asara/ABG-5437-2021; Almulla, Abbas F./G-7975-2018
OI Maes, Michael/0000-0002-2012-871X; Almulla, Abbas F./0000-0002-7667-6731
FU Ratchadapiseksompotch Fund, Graduate Affairs, Faculty of Medicine,
   Chulalongkorn University [GA64/21]; CU Graduate School Thesis Grant;
   Chulalongkorn University Graduate Scholarship [RA66/016]
FX This work was supported by the Ratchadapiseksompotch Fund, Graduate
   Affairs, Faculty of Medicine, Chulalongkorn University (Grant number
   GA64/21) , a grant from CU Graduate School Thesis Grant, and
   Chulalongkorn University Graduate Scholarship to Commemorate the 72nd
   Anniversary of His Majesty King Bhumibol Adulyadej to KJ, For the
   Thailand Science research and Innovation fund Chulalongkorn University,
   MDCU (RA66/016) to MM
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NR 117
TC 2
Z9 2
U1 8
U2 8
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0149-7634
EI 1873-7528
J9 NEUROSCI BIOBEHAV R
JI Neurosci. Biobehav. Rev.
PD FEB
PY 2025
VL 169
AR 106005
DI 10.1016/j.neubiorev.2025.106005
EA JAN 2025
PG 14
WC Behavioral Sciences; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Behavioral Sciences; Neurosciences & Neurology
GA X1T0F
UT WOS:001423246800001
PM 39793682
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Silverstein-Metzler, MG
   Frye, BM
   Justice, JN
   Clarkson, TB
   Appt, SE
   Carr, JJ
   Register, TC
   Albu-Shamah, M
   Shaltout, HA
   Shively, CA
AF Silverstein-Metzler, Marnie G.
   Frye, Brett M.
   Justice, Jamie N.
   Clarkson, Thomas B.
   Appt, Susan E.
   Carr, J. Jeffrey
   Register, Thomas C.
   Albu-Shamah, Mays
   Shaltout, Hossam A.
   Shively, Carol A.
TI Psychosocial stress increases risk for type 2 diabetes in female
   cynomolgus macaques consuming a western diet
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE Metabolic syndrome; Type 2 diabetes mellitus; Psychosocial stress;
   Nonhuman primate; Macaque
ID CORONARY-ARTERY ATHEROSCLEROSIS; HEART-RATE-VARIABILITY; SOCIAL-STATUS;
   SOCIOECONOMIC-STATUS; PSYCHOLOGICAL STRESS; SERTRALINE TREATMENT; SLEEP
   DURATION; WORK STRESS; BODY-FAT; DEPRESSION
AB Chronic psychosocial stress is associated with increased risk of many chronic diseases including type 2 diabetes mellitus. However, it is difficult to establish a causal relationship between stress and diabetes in human studies because stressors often are self-reported and may be distant in time from metabolic consequences. Macaques are useful models of the effects of chronic psychosocial stress on health and may develop obesity and diabetes similar to human beings. Thus, we studied the relationships between social subordination stress - a well-validated psychological stressor in macaques - and body composition and carbohydrate metabolism in socially housed, middle-aged female cynomolgus monkeys (Macaca fascicularis; n = 42). Following an 8-week baseline phase, the monkeys were fed a Western diet for 36 months (about equivalent to 10 human years). Social status was determined based on the outcomes of agonistic interactions ((X) over bar= 33.3 observation hours/monkey). Phenotypes collected included plasma cortisol, body composition, circulating markers of glucose metabolism, activity levels, and heart rate variability measured as RMSSD (root of mean square of successive differences) and SDDN (standard deviation of beat to beat interval) after 1.5- and 3-years on diet. Mixed model analyses of variance revealed that aggression received, submissions sent, and cortisol were higher, and RMSSD and SDNN were lower in subordinates than dominants (social status: p < 0.05). After 3 years of Western diet consumption, fasting triglyceride, glucose and insulin concentrations, calculated insulin resistance (HOMA-IR), body weight and body fat mass increased in all animals (time: all p's < 0.05); however, the increase in fasting glucose and HOMA-IR was significantly greater in subordinates than dominants (time x social status: p's < 0.05). Impaired glucose metabolism, (glucose > 100 mg/dl) incidence was significantly higher in subordinates (23%) than dominants (0%) (Fisher's exact test, p < 0.05). These findings suggest that chronic psychosocial stress, on a Western diet background, significantly increases type 2 diabetes risk in middle-aged female primates.
C1 [Silverstein-Metzler, Marnie G.; Frye, Brett M.; Clarkson, Thomas B.; Appt, Susan E.; Register, Thomas C.; Albu-Shamah, Mays; Shively, Carol A.] Wake Forest Sch Med, Dept Pathol Comparat Med, Winston Salem, NC 27101 USA.
   [Justice, Jamie N.] Wake Forest Sch Med, Internal Med Gerontol & Geriatr Med, Winston Salem, NC 27101 USA.
   [Carr, J. Jeffrey] Vanderbilt Univ, Sch Med, Dept Radiol & Radiol Sci, Nashville, TN 37212 USA.
   [Shaltout, Hossam A.] Wake Forest Sch Med, Dept Obstet & Gynecol, Winston Salem, NC 27101 USA.
C3 Wake Forest University; Wake Forest University; Vanderbilt University;
   Wake Forest University
RP Shively, CA (corresponding author), Dept Pathol Comparat Med, Med Ctr Blvd, Winston Salem, NC 27157 USA.
EM cshively@wakehealth.edu
RI Justice, Jamie/AAW-9590-2021; Shively, Carol/L-2921-2019; Register,
   Thomas/KLY-9188-2024; Shaltout, Hossam/F-6903-2013; Carr,
   John/A-1938-2012
OI Shaltout, Hossam/0000-0001-7948-3815; Register,
   Thomas/0000-0002-4078-0166; Carr, John/0000-0002-4398-8237
FU National Institute of Health, USA [RO1HL87103, R21MH86731, T32OD10957];
   Pepper Older Americans for Independence Center, USA [P30 AG21332]; NIH
   Office of the Director [T32OD010957] Funding Source: NIH RePORTER
FX We thank the following for their technical support: Beth Uberseder, Dana
   Morgan, Amanda Gogolak, Stephen Loiacono, Stephanie Willard, James
   Bottoms, Diane Wood and Maryanne Post. This work was supported in part
   by National Institute of Health, USA grants RO1HL87103, R21MH86731,
   T32OD10957, and the Pepper Older Americans for Independence Center, USA
   (P30 AG21332). The contents are solely the responsibility of the authors
   and do not necessarily represent the view of the NIH. None of the
   authors have any financial or competing interests to disclose.
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NR 73
TC 6
Z9 6
U1 1
U2 11
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
EI 1873-3360
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD MAY
PY 2022
VL 139
AR 105706
DI 10.1016/j.psyneuen.2022.105706
EA MAR 2022
PG 8
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA 2Q0MG
UT WOS:000820122900011
PM 35259592
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Gil, JS
   Drager, LF
   Guerra-Riccio, GM
   Mostarda, C
   Irigoyen, MC
   Costa-Hong, V
   Bortolotto, LA
   Egan, BM
   Lopes, HF
AF Gil, Juliana S.
   Drager, Luciano F.
   Guerra-Riccio, Grazia M.
   Mostarda, Cristiano
   Irigoyen, Maria C.
   Costa-Hong, Valeria
   Bortolotto, Luiz A.
   Egan, Brent M.
   Lopes, Heno F.
TI The impact of metabolic syndrome on metabolic, proinflammatory and
   prothrombotic markers according to the presence of high blood pressure
   criterion
SO CLINICS
LA English
DT Article
DE Hypertension; Sympathetic Activity; Insulin Resistance; Inflammation;
   Prothrombosis; Metabolic Syndrome
ID BODY-MASS INDEX; INSULIN-RESISTANCE; WAIST CIRCUMFERENCE; AUTONOMIC
   REGULATION; SLEEP-APNEA; OBESITY; HYPERTENSION; RISK; INSIGHTS; ANXIETY
AB OBJECTIVES: We explored whether high blood pressure is associated with metabolic, inflammatory and prothrombotic dysregulation in patients with metabolic syndrome.
   METHODS: We evaluated 135 consecutive overweight/obese patients. From this group, we selected 75 patients who were not under the regular use of medications for metabolic syndrome as defined by the current Expert Panel on Detection, Evaluation and Treatment of High Blood Cholesterol in Adults criteria. The patients were divided into metabolic syndrome with and without high blood pressure criteria (>= 130/>= 85 mmHg).
   RESULTS: Compared to the 45 metabolic syndrome patients without high blood pressure, the 30 patients with metabolic syndrome and high blood pressure had significantly higher glucose, insulin, homeostasis model assessment insulin resistance index, total cholesterol, low-density lipoprotein-cholesterol, triglycerides, uric acid and creatinine values; in contrast, these patients had significantly lower high-density lipoprotein-cholesterol values. Metabolic syndrome patients with high blood pressure also had significantly higher levels of retinol-binding protein 4, plasminogen activator inhibitor 1, interleukin 6 and monocyte chemoattractant protein 1 and lower levels of adiponectin. Moreover, patients with metabolic syndrome and high blood pressure had increased surrogate markers of sympathetic activity and decreased baroreflex sensitivity. Logistic regression analysis showed that high-density lipoprotein, retinol-binding protein 4 and plasminogen activator inhibitor-1 levels were independently associated with metabolic syndrome patients with high blood pressure. There is a strong trend for an independent association between metabolic syndrome patients with high blood pressure and glucose levels.
   CONCLUSIONS: High blood pressure, which may be related to the autonomic dysfunction, is associated with metabolic, inflammatory and prothrombotic dysregulation in patients with metabolic syndrome.
C1 [Gil, Juliana S.; Drager, Luciano F.; Guerra-Riccio, Grazia M.; Mostarda, Cristiano; Irigoyen, Maria C.; Costa-Hong, Valeria; Bortolotto, Luiz A.; Lopes, Heno F.] Univ Sao Paulo, Fac Med, Heart Inst InCor, Sao Paulo, Brazil.
   [Egan, Brent M.] Med Univ S Carolina, Charleston, SC 29425 USA.
   [Lopes, Heno F.] Univ Nove de Julho UNINOVE, Sao Paulo, Brazil.
C3 Universidade de Sao Paulo; Medical University of South Carolina;
   Universidade Nove de Julho
RP Gil, JS (corresponding author), Univ Sao Paulo, Fac Med, Heart Inst InCor, Sao Paulo, Brazil.
EM hipheno@incor.usp.br
RI Guerra, Grazia/AAQ-4433-2020; Mostarda, Cristiano/AAG-4087-2019; Drager,
   Luciano/A-1535-2014; Bortolotto, Luiz/S-1940-2017; Guerra, Grazia
   Maria/J-5865-2012; Lopes, Heno/H-9825-2013; Hong, Valeria Aparecida da
   Costa/S-9645-2017; Irigoyen, maria Claudia/N-6880-2014
OI Bortolotto, Luiz/0000-0002-4865-6442; Mostarda, Cristiano
   Teixeira/0000-0002-1305-1697; Guerra, Grazia Maria/0000-0003-4131-7904;
   Lopes, Heno/0000-0002-9591-3093; Drager, Luciano/0000-0002-2081-6846;
   Hong, Valeria Aparecida da Costa/0000-0003-1639-8095; Irigoyen, maria
   Claudia/0000-0003-2097-3662
FU FAPESP (Fundacao de Amparo a Pesquisa de Sao Paulo); Zerbini Foundation
FX This work was supported by grants from FAPESP (Fundacao de Amparo a
   Pesquisa de Sao Paulo) and Zerbini Foundation.
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NR 43
TC 10
Z9 11
U1 0
U2 8
PU HOSPITAL CLINICAS, UNIV SAO PAULO
PI SAO PAULO
PA FAC MEDICINA, UNIV SAO PAULO, SAO PAULO, SP 00000, BRAZIL
SN 1807-5932
EI 1980-5322
J9 CLINICS
JI Clinics
PY 2013
VL 68
IS 12
BP 1495
EP 1501
DI 10.6061/clinics/2013(12)04
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 293PR
UT WOS:000329985900004
PM 24473506
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Hege, A
   Lemke, MK
   Apostolopoulos, Y
   Whitaker, B
   Sönmez, S
AF Hege, Adam
   Lemke, Michael K.
   Apostolopoulos, Yorghos
   Whitaker, Brian
   Sonmez, Sevil
TI Work-Life Conflict among US Long-Haul Truck Drivers: Influences of Work
   Organization, Perceived Job Stress, Sleep, and Organizational Support
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Article
DE long-haul truck drivers; work-life balance; work organization; sleep;
   job stress; occupational health disparities
ID TO-FAMILY CONFLICT; MENTAL-HEALTH; RISK-FACTORS; CARDIOMETABOLIC RISK;
   SYSTEMS THINKING; SAFETY CLIMATE; ENVIRONMENT; BALANCE; QUALITY; OBESITY
AB Work-life balance and job stress are critical to health and well-being. Long-haul truck driving (LHTD) is among the unhealthiest and most unsafe occupations in the U.S. Despite these disparities, there are no extant published studies examining the influence of work, stress and sleep outcomes on drivers' work-life balance. The current study investigated whether adverse work organization, stress, and poor sleep health among LHTDs are significantly associated with work-life conflict. Logistic regression was used to examine how work organization characteristics, job stress, and sleep influenced perceived stress and a composite measure of work-life conflict among a sample of 260 U.S. LHTDs. The pattern of regression results dictated subsequent analyses using structural equation modeling (SEM). Perceived job stress was the only statistically significant predictor for work-life balance. Fast pace of work, sleep duration and sleep quality were predictors of perceived job stress. SEM further elucidated that stress mediates the influences of fast work pace, supervisor/coworker support, and low sleep duration on each of the individual work-life balance indicators. There is an urgent need to address work conditions of LHTDs to better support their health, well-being, and work-life balance. Specifically, the findings from this study illustrate that scheduling practices and sleep outcomes could alleviate job stress and need to be addressed to more effectively support work-life balance. Future research and interventions should focus on policy and systems-level change.
C1 [Hege, Adam] Appalachian State Univ, Dept Hlth & Exercise Sci, Publ Hlth Program, Leon Levine Hall,1179 State Farm Rd,POB 32071, Boone, NC 28607 USA.
   [Lemke, Michael K.] Univ Houston Downtown, Dept Social Sci, One Main St, Houston, TX 77002 USA.
   [Lemke, Michael K.; Apostolopoulos, Yorghos] Texas A&M Univ, Complex & Computat Populat Hlth Grp, College Stn, TX 77843 USA.
   [Apostolopoulos, Yorghos] Texas A&M Univ, Dept Hlth & Kinesiol, College Stn, TX 77843 USA.
   [Whitaker, Brian] Appalachian State Univ, Dept Management, 416 Howard St,POB 32089, Boone, NC 28608 USA.
   [Sonmez, Sevil] Univ Cent Florida, Coll Business Adm, 12744 Pegasus Dr, Orlando, FL 32816 USA.
C3 University of North Carolina; Appalachian State University; University
   of Houston System; University of Houston; University of Houston
   Downtown; Texas A&M University System; Texas A&M University College
   Station; Texas A&M University System; Texas A&M University College
   Station; University of North Carolina; Appalachian State University;
   State University System of Florida; University of Central Florida
RP Hege, A (corresponding author), Appalachian State Univ, Dept Hlth & Exercise Sci, Publ Hlth Program, Leon Levine Hall,1179 State Farm Rd,POB 32071, Boone, NC 28607 USA.
EM hegeba@appstate.edu; lemkem@uhd.edu; yaposto@hlkn.tamu.edu;
   whitakerbg@appstate.edu; sevil@ucf.edu
RI Hege, Adam/AGF-0054-2022
OI Hege, Adam/0000-0003-2515-6848
FU University of North Carolina at Greensboro; Appalachian State University
FX This research received no external funding. However, we are appreciative
   of funding provided by the University of North Carolina at Greensboro
   and Appalachian State University to support data collection efforts and
   development of the manuscript.
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NR 123
TC 44
Z9 51
U1 6
U2 57
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD MAR 2
PY 2019
VL 16
IS 6
AR 984
DI 10.3390/ijerph16060984
PG 19
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA HU3GB
UT WOS:000465159500084
PM 30893828
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Mulero, J
   Bernabé, J
   Cerdá, B
   García-Viguera, C
   Moreno, DA
   Albaladejo, MD
   Avilés, F
   Parra, S
   Abellán, J
   Zafrilla, P
AF Mulero, Juana
   Bernabe, Juana
   Cerda, Begona
   Garcia-Viguera, Cristina
   Moreno, Diego A.
   Dolores Albaladejo, Ma
   Aviles, Francisco
   Parra, Soledad
   Abellan, Jose
   Zafrilla, Pilar
TI Variations on cardiovascular risk factors in metabolic syndrome after
   consume of a citrus-based juice
SO CLINICAL NUTRITION
LA English
DT Article
DE Oxidative stress; Metabolic syndrome; LDL oxidized; C-Reactive protein;
   Homocysteine
ID LOW-DENSITY-LIPOPROTEIN; C-REACTIVE PROTEIN; CIRCULATING OXIDIZED LDL;
   OXIDATIVE STRESS; BLOOD-PRESSURE; VITAMIN-C; HEALTH; HOMOCYSTEINE;
   ASSOCIATION; CHOKEBERRY
AB Background & aims: Inflammation and oxidative stress plays a critical role in cardiovascular disease and metabolic syndrome often occurs with these two variables. The aim of the study is to estimate variations on cardiovascular risk factors in Metabolic Syndrome patients after consume of a citrus-based juice compared with control groups.
   Methods: The study comprised 20 healthy subjects and 33 patients with Metabolic Syndrome. 18 patients consume daily 300 mL of a citrus-based juice during 6 month and 15 patients consume 300 mL of a placebo beverage. The control group consumes a citrus-based juice. Before, at fourth month and at sixth month after treatment the following parameters were determined: lipid profile, oxidized LDL, C-Reactive Protein and Homocysteine. The study was carried out in accordance with the Helsinki Declaration, and the Ethical Committee of the San Antonio Catholic University and approved the protocol (6 November 2006, register number: 1424).
   Results: After six months of citrus-based juice consuming, there is significant differences at 95% confidence in oxidized LDL, C-Reactive Protein, and Homocysteine in Metabolic Syndrome patients who consume citrus-based juice. We have not found significant differences in other groups.
   Conclusions: Consume of citrus-based juice improve lipid profile and inflammation markers in Metabolic Syndrome patients. (C) 2011 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.
C1 [Mulero, Juana; Bernabe, Juana; Cerda, Begona; Zafrilla, Pilar] Catholic Univ San Antonio, Dept Food Technol & Nutr, Murcia 30107, Spain.
   [Garcia-Viguera, Cristina; Moreno, Diego A.] Res Grp Qual Safety Ea Bioact Plant Food, Dept Food Sci & Technol, CEBAS, CSIC, Murcia 30100, Spain.
   [Dolores Albaladejo, Ma; Aviles, Francisco; Parra, Soledad] Hosp Univ Virgen de la Arrixaca, Murcia 30120, Spain.
   [Abellan, Jose] Catholic Univ San Antonio, Chair Cardiovasc Risk, Murcia 30107, Spain.
C3 Universidad Catolica de Murcia; Consejo Superior de Investigaciones
   Cientificas (CSIC); CSIC - Centro de Edafologia y Biologia Aplicada del
   Segura (CEBAS); Hospital Clinico Universitario Virgen de la Arrixaca;
   Universidad Catolica de Murcia
RP Mulero, J (corresponding author), Catholic Univ San Antonio, Dept Food Technol & Nutr, Murcia 30107, Spain.
EM jmulero@pdi.ucam.edu
RI Zafrilla, Pilar/JAN-5983-2023; Avilés, Francis/AEB-5532-2022; Begona,
   Cerda/K-5993-2014; GARCIA-VIGUERA, CRISTINA/B-2153-2012;
   Moreno-Fernandez, Diego Angel/G-4379-2011
OI ZAFRILLA, PILAR/0000-0002-1463-7120; Begona, Cerda/0000-0003-0385-1145;
   GARCIA-VIGUERA, CRISTINA/0000-0002-4751-3917; Moreno-Fernandez, Diego
   Angel/0000-0002-6547-8764
FU Comision Interministerial de Ciencia y Tecnologia (CICYT)
FX The authors acknowledge the financial support of Comision
   Interministerial de Ciencia y Tecnologia (CICYT).
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U1 1
U2 13
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0261-5614
EI 1532-1983
J9 CLIN NUTR
JI Clin. Nutr.
PD JUN
PY 2012
VL 31
IS 3
BP 372
EP 377
DI 10.1016/j.clnu.2011.11.014
PG 6
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 960DO
UT WOS:000305368400010
PM 22197455
DA 2025-06-11
ER

PT J
AU Song, BC
   Joo, NS
   Aldini, G
   Yeum, KJ
AF Song, Byeng Chun
   Joo, Nam-Seok
   Aldini, Giancarlo
   Yeum, Kyung-Jin
TI Biological functions of histidine-dipeptides and metabolic syndrome
SO NUTRITION RESEARCH AND PRACTICE
LA English
DT Review
DE Carnosine; anserine; metabolic syndrome; CNDP-1 genotype; advanced
   glycoxidation end products (AGEs)
ID INCREASED OXIDATIVE STRESS; VITAMIN-E SUPPLEMENTATION;
   N-CARBOXYMETHYL-LYSINE; L-CARNOSINE; MULTIVITAMIN USE; LEUCINE REPEAT;
   DNA-DAMAGE; PROTEIN; DISEASE; TYPE-2
AB The rapid increase in the prevalence of metabolic syndrome, which is associated with a state of elevated systemic oxidative stress and inflammation, is expected to cause future increases in the prevalence of diabetes and cardiovascular diseases. Oxidation of polyunsaturated fatty acids and sugars produces reactive carbonyl species, which, due to their electrophilic nature, react with the nucleophilic sites of certain amino acids. This leads to formation of protein adducts such as advanced glycoxidation/lipoxidation end products (AGEs/ALEs), resulting in cellular dysfunction. Therefore, an effective reactive carbonyl species and AGEs/ALEs sequestering agent may be able to prevent such cellular dysfunction. There is accumulating evidence that histidine containing dipeptides such as camosine (beta-alanyl-L-histidine) and anserine (beta-alanyl-methyl-L-histidine) detoxify cytotoxic reactive carbonyls by forming unreactive adducts and are able to reverse glycated protein. In this review, 1) reaction mechanism of oxidative stress and certain chronic diseases, 2) interrelation between oxidative stress and inflammation, 3) effective reactive carbonyl species and AGEs/ALEs sequestering actions of histidine-dipeptides and their metabolism, 4) effects of carnosinase encoding gene on the effectiveness of histidine-dipeptides, and 5) protective effects of histidine-dipeptides against progression of metabolic syndrome are discussed. Overall, this review highlights the potential beneficial effects of histidine-dipeptides against metabolic syndrome. Randomized controlled human studies may provide essential information regarding whether histidine-dipeptides attenuate metabolic syndrome in humans.
C1 [Song, Byeng Chun; Yeum, Kyung-Jin] Konkuk Univ, Coll Biomed & Hlth Sci, Div Food Biosci, Chungju 380701, Chungbuk, South Korea.
   [Joo, Nam-Seok] Ajou Univ, Sch Med, Gyeonggi 443749, South Korea.
   [Aldini, Giancarlo] Univ Milan, Dept Pharmaceut Sci, I-20122 Milan, Italy.
C3 Konkuk University; Ajou University; University of Milan
RP Yeum, KJ (corresponding author), Konkuk Univ, Coll Biomed & Hlth Sci, Div Food Biosci, 268 Chungwondaero, Chungju 380701, Chungbuk, South Korea.
EM kyeum@kku.ac.kr
RI aldini, giancarlo/C-3533-2013
OI Yeum, Kyung-Jin/0000-0002-7846-0272; aldini,
   giancarlo/0000-0002-2355-6744
FU Cooperative Research Program for Agriculture Science & Technology Rural
   Development Administration, Republic of Korea [PJ008755]
FX This study was supported in part by the Cooperative Research Program for
   Agriculture Science & Technology (PJ008755) Rural Development
   Administration, Republic of Korea.
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NR 73
TC 48
Z9 52
U1 0
U2 33
PU KOREAN NUTRITION SOC
PI SEOUL
PA 804 KST CTR, 635-4 YEOGSAM-SONG KANGNAM-KU, SEOUL, 135-703, SOUTH KOREA
SN 1976-1457
EI 2005-6168
J9 NUTR RES PRACT
JI Nutr. Res. Pract.
PD FEB
PY 2014
VL 8
IS 1
BP 3
EP 10
DI 10.4162/nrp.2014.8.1.3
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA AA0WW
UT WOS:000330819100001
PM 24611099
OA Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Gilbert, EW
   Tay, CT
   Hiam, DS
   Teede, HJ
   Moran, LJ
AF Gilbert, Emily W.
   Tay, Chau T.
   Hiam, Danielle S.
   Teede, Helena J.
   Moran, Lisa J.
TI Comorbidities and complications of polycystic ovary syndrome: An
   overview of systematic reviews
SO CLINICAL ENDOCRINOLOGY
LA English
DT Review
DE comorbidity; hyperandrogenism; insulin resistance; metabolic syndrome;
   obesity; PCOS; polycystic ovary syndrome
ID QUALITY-OF-LIFE; CARDIOVASCULAR-DISEASE RISK; IMPAIRED
   GLUCOSE-TOLERANCE; VITAMIN-D; POSITION STATEMENT; INSULIN-RESISTANCE;
   METABOLIC SYNDROME; ANDROGEN EXCESS; SYNDROME PCOS; WOMEN
AB Background Polycystic ovary syndrome (PCOS) is one of the most common endocrinopathies affecting reproductive-aged women with adverse reproductive, metabolic and psychological outcomes. It has a complex pathophysiology and therefore requires a multidiscipline clinical approach. However, there remains limited research synthesizing the broad clinical implications of PCOS which would assist clinicians in the management of PCOS. Objective To summarize and appraise methodological quality of systematic reviews and meta-analyses evaluating complications and comorbidities associated with PCOS. Methods A literature search from MEDLINE, EMBASE, CINAHL PLUS and PROSPERO was performed until 15 September 2017. Article selection, data extraction and quality appraisal of included reviews using the Assessing the Methodological Quality of Systematic Reviews (AMSTAR) tool were performed in duplicate. A narrative synthesis of the findings was conducted. Results Twenty-three reviews were included. All reviews were of low (n = 2) to moderate quality (n = 21). PCOS was associated with adverse pregnancy outcomes (n = 2), impaired glucose tolerance (n = 6), insulin resistance (n = 6), increased risk of type 2 diabetes (n = 1), cardiovascular disease (n = 10), metabolic syndrome (n = 2), psychological stress (n = 7), endometrial cancer (n = 1) and vitamin D deficiency (n = 1). Obesity exacerbates many of these outcomes. Conclusions There is a large body of reliable evidence for adverse metabolic outcomes and smaller, but consistent evidence for psychological issues in PCOS. We identified a shortage of systematic reviews regarding pregnancy outcomes of PCOS and significant gaps in knowledge of the association between PCOS and subclinical hyperthyroidism, vitamin D levels and cancers which future studies could aim to address.
C1 [Gilbert, Emily W.; Tay, Chau T.; Teede, Helena J.; Moran, Lisa J.] Monash Univ, Sch Publ Hlth & Preventat Med, Monash Ctr Hlth Res & Implementat, Clayton, Vic, Australia.
   [Tay, Chau T.; Teede, Helena J.] Monash Hlth, Dept Endocrinol & Diabet, Clayton, Vic, Australia.
   [Hiam, Danielle S.] Victoria Univ, Inst Hlth Exercise & Sport, Melbourne, Vic, Australia.
   [Moran, Lisa J.] Univ Adelaide, Robinson Res Inst, Discipline Obstet & Gynaecol, Adelaide, SA, Australia.
C3 Monash University; Monash Health; Victoria University; University of
   Adelaide; Robinson Research Institute
RP Gilbert, EW (corresponding author), Monash Univ, Sch Publ Hlth & Preventat Med, Monash Ctr Hlth Res & Implementat, Clayton, Vic, Australia.
EM emily.gilbert@monash.edu
RI Moran, Lisa/E-9850-2015; Hiam, Danielle/AAD-4160-2021; Tay,
   Jillian/AAE-6749-2020
OI Gilbert, Emily/0000-0002-2061-8196; Tay, Chau Thien/0000-0001-6228-2654;
   Hiam, Danielle/0000-0003-0135-329X; Moran, Lisa/0000-0001-5772-6484;
   Teede, Helena/0000-0001-7609-577X
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NR 70
TC 102
Z9 107
U1 1
U2 35
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0300-0664
EI 1365-2265
J9 CLIN ENDOCRINOL
JI Clin. Endocrinol.
PD DEC
PY 2018
VL 89
IS 6
BP 683
EP 699
DI 10.1111/cen.13828
PG 17
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA HA9WL
UT WOS:000450658800001
PM 30099747
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Yeh, TK
   Cho, YC
   Yeh, TC
   Hu, CY
   Lee, LC
   Chang, CY
AF Yeh, Ting-Kuang
   Cho, Ying-Chun
   Yeh, Ting-Chi
   Hu, Chung-Yi
   Lee, Li-Ching
   Chang, Chun-Yen
TI An Exploratory Analysis of the Relationship between Cardiometabolic Risk
   Factors and Cognitive/Academic Performance among Adolescents
SO BIOMED RESEARCH INTERNATIONAL
LA English
DT Article
ID BODY-MASS INDEX; ELEVATED BLOOD-PRESSURE; SCHOOL-AGE-CHILDREN;
   NATIONAL-HEALTH; CENTRAL OBESITY; OLDER; HYPERTENSION; DEMENTIA;
   POPULATION; DEPRESSION
AB This exploratory study examines the relationship between cardiometabolic risk factors (blood pressure, waist circumference, BMI, and total cholesterol) and cognitive/academic performance. In this study, 1297 Taiwanese tenth-grade volunteers are recruited. Scores from the Basic Competency Test, an annual national competitive entrance examination, are used to evaluate academic performance. Cognitive abilities are accessed via the Multiple Aptitude Test Battery. The results indicate that systolic blood pressure is significantly, negatively associated with academic performance, both in male and female subjects. BMI and waist circumference are associated with verbal reasoning performance with an inverse U-shaped pattern, suggesting that both low and high BMI/waist circumference may be associated with lower verbal reasoning performance.
C1 [Yeh, Ting-Kuang; Cho, Ying-Chun; Lee, Li-Ching; Chang, Chun-Yen] Natl Taiwan Normal Univ, Sci Educ Ctr, Taipei 116, Taiwan.
   [Yeh, Ting-Kuang; Cho, Ying-Chun; Lee, Li-Ching; Chang, Chun-Yen] Natl Taiwan Normal Univ, Grad Inst Sci Educ, Taipei 116, Taiwan.
   [Yeh, Ting-Kuang] Natl Taiwan Normal Univ, Inst Marine Environm Sci & Technol, Taipei 116, Taiwan.
   [Yeh, Ting-Kuang; Chang, Chun-Yen] Natl Taiwan Normal Univ, Dept Life Sci, Taipei 116, Taiwan.
   [Yeh, Ting-Chi] Mackay Mem Hosp, Dept Pediat, Taipei 104, Taiwan.
   [Hu, Chung-Yi] Natl Taiwan Univ, Coll Med, Dept Clin Lab Sci & Med Biotechnol, Taipei 100, Taiwan.
C3 National Taiwan Normal University; National Taiwan Normal University;
   National Taiwan Normal University; National Taiwan Normal University;
   Mackay Memorial Hospital; National Taiwan University
RP Lee, LC (corresponding author), Natl Taiwan Normal Univ, Sci Educ Ctr, 88 Sect 4,Ting Chou Rd, Taipei 116, Taiwan.
EM lclee@ntnu.edu.tw; changcy@ntnu.edu.tw
RI Hu, Che-Ming/N-7674-2018; Chang, Chun-Yen/B-1307-2008
OI HU, CHUNG-YI/0000-0002-6990-3297; Chang, Chun-Yen/0000-0003-2373-2004;
   Yeh, Ting-Kuang/0000-0002-3093-693X
FU National Science Council of Taiwan [NSC
   102-2511-S-003-007-MY2/S-003-008-MY2]; Aim for the Top University
   Project-NTNU
FX The work in this study was supported by the National Science Council of
   Taiwan under Contracts NSC 102-2511-S-003-007-MY2/S-003-008-MY2 and Aim
   for the Top University Project-NTNU. The authors gratefully appreciate
   the assistance provided by Professor Tai Li Chou and Terrence Wong for
   consultation and editing. The authors thank the editor and anonymous
   reviewers for their insightful comments on an earlier version of the
   paper. Above all, the authors appreciate all the students and their
   families for giving their consent to participation in this project.
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NR 42
TC 7
Z9 7
U1 0
U2 3
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2314-6133
EI 2314-6141
J9 BIOMED RES INT
JI Biomed Res. Int.
PY 2015
VL 2015
AR 520619
DI 10.1155/2015/520619
PG 9
WC Biotechnology & Applied Microbiology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Biotechnology & Applied Microbiology; Research & Experimental Medicine
GA CL1EI
UT WOS:000356685100001
PM 26137484
OA Green Published, hybrid, Green Submitted
DA 2025-06-11
ER

PT J
AU Razzoli, M
   Pearson, C
   Crow, S
   Bartolomucci, A
AF Razzoli, Maria
   Pearson, Carolyn
   Crow, Scott
   Bartolomucci, Alessandro
TI Stress, overeating, and obesity: Insights from human studies and
   preclinical models
SO NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
LA English
DT Article; Proceedings Paper
CT Annual Meeting of the International-Behavioral-Neuroscience-Society
   (IBNS)
CY 2015
CL Victoria, CANADA
SP Int Behav Neuroscience Soc
DE Animal model; Chronic subordination stress; Social stress; Stress;
   Negative affect; Ecological momentary assessment
ID BINGE-EATING DISORDER; CHRONIC SOCIAL STRESS; PSYCHOSOCIAL STRESS;
   NEGATIVE AFFECT; FOOD-INTAKE; METABOLIC SYNDROME; ANIMAL-MODELS; CALORIC
   RESTRICTION; CORTISOL RESPONSE; ABDOMINAL OBESITY
AB Eating disorders and obesity have become predominant in human society. Their association to modern lifestyle, encompassing calorie-rich diets, psychological stress, and comorbidity with major diseases are well documented. Unfortunately the biological basis remains elusive and the pharmacological treatment inadequate, in part due to the limited availability of valid animal models. Human research on binge eating disorder (BED) proves a strong link between stress exposure and bingeing: state-levels of stress and negative affect are linked to binge eating in individuals with BED both in laboratory settings and the natural environment. Similarly, classical animal models of BED reveal an association between acute exposure to stressors and binging but they are often associated with unchanged or decreased body weight, thus reflecting a negative energy balance, which is uncommon in humans where most commonly BED is associated with excessive or unstable body weight gain. Recent mouse models of subordination stress induce spontaneous binging and hyperphagia, altogether more closely mimicking the behavioral and metabolic features of human BED. Therefore the translational relevance of subordination stress models could facilitate the identification of the neurobiological basis of BED and obesity-associated disease and inform on the development of innovative therapies. (C) 2017 Elsevier Ltd. All rights reserved.
C1 [Razzoli, Maria; Bartolomucci, Alessandro] Univ Minnesota, Dept Integrat Biol & Physiol, 2231 6th St SE, Minneapolis, MN 55455 USA.
   [Pearson, Carolyn; Crow, Scott] Univ Minnesota, Dept Psychiat, 2450 Riverside Ave, Minneapolis, MN 55454 USA.
   [Crow, Scott] Emily Program, 2265 Como Ave, St Paul, MN 55108 USA.
C3 University of Minnesota System; University of Minnesota Twin Cities;
   University of Minnesota System; University of Minnesota Twin Cities
RP Bartolomucci, A (corresponding author), Univ Minnesota, Dept Integrat Biol & Physiol, 2231 6th St SE, Minneapolis, MN 55455 USA.
EM abartolo@umn.edu
RI Bartolomucci, Alessandro/MFI-6219-2025
OI RAZZOLI, Maria/0000-0001-5911-4633; Bartolomucci,
   Alessandro/0000-0001-6439-8829
FU NIH/NIDDK [R01DK102496]; NIH/NIA [R01AG043972]; NIDDK/NIH [P30DK50456];
   NIMH/NIH [T32082761]; NIH/NIDDK [R01DK102496]; NIH/NIA [R01AG043972];
   NIDDK/NIH [P30DK50456]; NIMH/NIH [T32082761]
FX AB is supported by NIH/NIDDK R01DK102496, NIH/NIA R01AG043972. SC is
   supported by NIDDK/NIH P30DK50456, and CP is supported by
   NIMH/NIHT32082761
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NR 144
TC 153
Z9 166
U1 2
U2 48
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0149-7634
EI 1873-7528
J9 NEUROSCI BIOBEHAV R
JI Neurosci. Biobehav. Rev.
PD MAY
PY 2017
VL 76
BP 154
EP 162
DI 10.1016/j.neubiorev.2017.01.026
PN A
PG 9
WC Behavioral Sciences; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI); Conference Proceedings Citation Index - Science (CPCI-S)
SC Behavioral Sciences; Neurosciences & Neurology
GA ET5RG
UT WOS:000400341700017
PM 28292531
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Miller, GE
   Chen, E
   Yu, TY
   Brody, GH
AF Miller, Gregory E.
   Chen, Edith
   Yu, Tianyi
   Brody, Gene H.
TI Youth Who Achieve Upward Socioeconomic Mobility Display Lower
   Psychological Distress But Higher Metabolic Syndrome Rates as Adults:
   Prospective Evidence From Add Health and MIDUS
SO JOURNAL OF THE AMERICAN HEART ASSOCIATION
LA English
DT Article
DE depression; metabolic syndrome; socioeconomic position
ID AFRICAN-AMERICANS; UNITED-STATES; RISK-FACTORS; DISPARITIES; RESILIENCE;
   RACE
AB Background
   People with higher socioeconomic status generally enjoy better cardiovascular health across the life course than those with lower status. However, recent studies of upward mobility, where a child goes on to achieve higher socioeconomic status than his or her parents, suggest that it entails a tradeoff between better psychological well-being and worse cardiometabolic health. In this study, we consider further evidence of this tradeoff in 2 multidecade studies, asking how upward income mobility relates to subsequent perceived stress, depressive symptoms, and metabolic syndrome. We ask parallel questions about downward mobility. Finally, given shifting patterns of mobility in recent generations, we also consider whether mobility's association with health outcomes differs for individuals born in the middle and later parts of the 20th century.
   Methods and Results
   We analyzed prospective data from Add Health (National Longitudinal Study of Adolescent Health; N=7542) and MIDUS (Midlife in the United States Study; N=1877). In both studies, evidence of the tradeoff was observed. Upward mobility presaged lower perceived stress and fewer depressive symptoms, in combination with higher metabolic syndrome rates. In contrast, downward mobility presaged worse outcomes on all health indicators. The magnitude of the mobility-health associations was similar across cohorts.
   Conclusions
   These findings provide evidence that upward income mobility is associated with a tradeoff between well-being and cardiometabolic health. The similarity of the findings across cohorts suggests that this tradeoff is a generalized consequence of ascending the socioeconomic hierarchy, at least for Americans born in the middle and later parts of the 20th century.
C1 [Miller, Gregory E.; Chen, Edith] Northwestern Univ, Inst Policy Res, Evanston, IL USA.
   [Miller, Gregory E.; Chen, Edith] Northwestern Univ, Dept Psychol, Evanston, IL USA.
   [Yu, Tianyi; Brody, Gene H.] Univ Georgia, Ctr Family Res, Athens, GA 30602 USA.
C3 Northwestern University; Northwestern University; University System of
   Georgia; University of Georgia
RP Miller, GE (corresponding author), Inst Policy Res, 2040 Sheridan Rd, Evanston, IL 60208 USA.
EM greg.miller@northwestern.edu
OI Miller, Gregory/0000-0002-7217-1082
FU National Institute of Child Health and Human Development [HD093718,
   HD091046]; National Heart, Lung, and Blood Institute [HL122328];
   National Institute on Drug Abuse [DA027827]
FX Preparation of this article was supported by grants from the National
   Institute of Child Health and Human Development (HD093718, HD091046);
   the National Heart, Lung, and Blood Institute (HL122328); and the
   National Institute on Drug Abuse (DA027827).
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NR 34
TC 29
Z9 32
U1 1
U2 13
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2047-9980
J9 J AM HEART ASSOC
JI J. Am. Heart Assoc.
PD MAY 5
PY 2020
VL 9
IS 9
AR e015698
DI 10.1161/JAHA.119.015698
PG 14
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Cardiovascular System & Cardiology
GA LV0PG
UT WOS:000538145600038
PM 32340532
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Sohn, YJ
   Sohn, HS
   Kwon, JW
AF Sohn, Yeo-Jin
   Sohn, Hyun Soon
   Kwon, Jin-Won
TI Gender differences among middle-aged Koreans for health-related quality
   of life related to metabolic syndrome
SO QUALITY OF LIFE RESEARCH
LA English
DT Article
DE Metabolic syndrome; Health-related quality of life; EQ-5D; Gender
   difference
ID 3RD NATIONAL-HEALTH; CARDIOVASCULAR-DISEASE; SYNDROME-X; OBESITY;
   ASSOCIATION; DEPRESSION; US; RISK; PREVALENCE; VALIDATION
AB The influence of metabolic syndrome (MS) on quality of life has not been studied much among Asians, especially Koreans. This study compared the association between MS and health-related quality of life (HRQL) by gender for middle-aged Koreans.
   We used data containing 2,264 adults between the ages of 40 and 59 years who participated in the 2005 Korean National Health and Nutrition Examination Surveys. The criteria for MS were defined by the National Cholesterol Education Program Adult Treatment Panel III. HRQL was measured by the EQ-5D preference score. Good health status was defined as having higher scores than the mean EQ5D preference score. We used logistic regression methods to adjust for socioeconomic covariates and survey sample design.
   The mean EQ-5D preference score was significantly lower in women with MS compared to women without MS (0.81 vs. 0.88), but this was not the case for men (0.92 vs. 0.92). These consistent results were observed after adjusting for socioeconomic covariates. In multiple logistic analyses, women with MS had a lower likelihood of having good health status compared to women without MS (OR = 0.60, 95% CI 0.38-0.96). For men, there was no difference.
   Our study identified a nationally representative health preference score for MS in Korean middle-aged men and women while highlighting a gender difference that merits more research (i.e., MS appeared to have a significant negative impact for women's HRQL, but not for men). At the very least, future studies should consider gender differences when addressing quality of life among patients with MS.
C1 [Kwon, Jin-Won] Rutgers State Univ, Sch Pharm, Dept Pharm Practice & Adm, Piscataway, NJ 08854 USA.
   [Sohn, Yeo-Jin] Seoul Natl Univ, Grad Sch Publ Hlth, Dept Hlth Sci & Serv, Seoul, South Korea.
   [Sohn, Hyun Soon] Sookmyung Womens Univ, Coll Pharm, Seoul, South Korea.
C3 Rutgers University System; Rutgers University New Brunswick; Seoul
   National University (SNU); Sookmyung Women's University
RP Kwon, JW (corresponding author), Rutgers State Univ, Sch Pharm, Dept Pharm Practice & Adm, 160 Frelinghuysen Rd, Piscataway, NJ 08854 USA.
EM jinweonkwon@gmail.com
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NR 50
TC 13
Z9 13
U1 0
U2 8
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0962-9343
EI 1573-2649
J9 QUAL LIFE RES
JI Qual. Life Res.
PD MAY
PY 2011
VL 20
IS 4
BP 583
EP 592
DI 10.1007/s11136-010-9789-z
PG 10
WC Health Care Sciences & Services; Health Policy & Services; Public,
   Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services; Public, Environmental & Occupational
   Health
GA 749PP
UT WOS:000289481100015
PM 21063785
DA 2025-06-11
ER

PT J
AU Happell, B
   Gaskin, CJ
   Stanton, R
AF Happell, Brenda
   Gaskin, Cadeyrn J.
   Stanton, Robert
TI Addressing the physical health of people with serious mental illness: A
   potential solution for an enduring problem
SO INTERNATIONAL JOURNAL OF SOCIAL PSYCHIATRY
LA English
DT Article
DE Cardiovascular disease; mental health consumers; metabolic syndrome;
   nursing; physical health
ID CARE
AB People with serious mental illness face significant inequalities in physical health care. As a result, the risk of cardiometabolic disorders and premature mortality is far greater than that observed in the general population. Contributiung to this disparity, is the lack of routine physical health screening by mental health clinicians. One possible solution is the implimentation of a physical health nurse consultant, whose role is to monitor and coordinate the physical health care of people with serious mental illness. Current evidence supports the implimentation of such a role, and a failure to address the widening gaps in physical health care will only serve to increase the disparities faced by people with serious mental illness.
C1 [Happell, Brenda] Univ Canberra, SYNERGY Nursing & Midwifery Res Ctr, Canberra, ACT 2601, Australia.
   [Happell, Brenda] ACT Hlth, Canberra, ACT, Australia.
   [Gaskin, Cadeyrn J.] Gaskin Res, Melbourne, Vic, Australia.
   [Gaskin, Cadeyrn J.; Stanton, Robert] CQUniv, Sch Med & Appl Sci, Rockhampton, Qld, Australia.
C3 University of Canberra; ACT Health Australia; Central Queensland
   University
RP Stanton, R (corresponding author), CQUniv, Sch Med & Appl Sci, Bruce Highway, North Rockhampton, Qld 4702, Australia.
EM r.stanton@cqu.edu.au
RI Stanton, Rob/AAJ-5157-2020; Happell, Brenda/HSI-0570-2023
OI Gaskin, Cadeyrn/0000-0001-5240-4320; Happell, Brenda/0000-0002-7293-6583
FU Queensland Centre for Social Science Innovation
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: The
   authors acknowledge the funding provided by the (former) Queensland
   Centre for Social Science Innovation.
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NR 10
TC 7
Z9 7
U1 0
U2 6
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0020-7640
EI 1741-2854
J9 INT J SOC PSYCHIATR
JI Int. J. Soc. Psychiatr.
PD MAR
PY 2016
VL 62
IS 2
BP 201
EP 202
DI 10.1177/0020764015621771
PG 2
WC Psychiatry
WE Social Science Citation Index (SSCI)
SC Psychiatry
GA DE1YF
UT WOS:000370422200013
PM 26714761
DA 2025-06-11
ER

PT J
AU Elnakish, MT
   Hassanain, HH
   Janssen, PM
   Angelos, MG
   Khan, M
AF Elnakish, Mohammad T.
   Hassanain, Hamdy H.
   Janssen, Paul M.
   Angelos, Mark G.
   Khan, Mahmood
TI Emerging role of oxidative stress in metabolic syndrome and
   cardiovascular diseases: important role of Rac/NADPH oxidase
SO JOURNAL OF PATHOLOGY
LA English
DT Review
DE oxidative stress; metabolic syndrome; cardiovascular disease
ID ISCHEMIA-REPERFUSION INJURY; SMOOTH-MUSCLE-CELLS; SPONTANEOUSLY
   HYPERTENSIVE-RATS; SALT-SENSITIVE HYPERTENSION; CARDIAC MYOCYTE
   HYPERTROPHY; FREE-RADICAL PRODUCTION; CORONARY-HEART-DISEASE;
   FACTOR-KAPPA-B; NADPH OXIDASE; ANGIOTENSIN-II
AB 'Oxidative stress' is a term defining states of elevated reactive oxygen species (ROS) levels. Normally, ROS control several physiological processes, such as host defence, biosynthesis of hormones, fertilization and cellular signalling. However, oxidative stress has been involved in different pathologies, including metabolic syndrome and numerous cardiovascular diseases. A major source of ROS involved in both metabolic syndrome and cardiovascular pathophysiology is the NADPH oxidase (NOX) family of enzymes. NOX is a multi-component enzyme complex that consists of membrane-bound cytochrome b-558, which is a heterodimer of gp91phox and p22phox, cytosolic regulatory subunits p47phox and p67phox, and the small GTP-binding protein Rac1. Rac1 plays many important biological functions in cells, but perhaps the most unique function of Rac1 is its ability to bind and activate the NOX complex. Furthermore, Rac1 has been reported to be a key regulator of oxidative stress through its co-regulatory effects on both nitric oxide (NO) synthase and NOX. Therefore, the main goal of this review is to give a brief outline about the important role of the Rac1-NOX axis in the pathophysiology of both metabolic syndrome and cardiovascular disease. Copyright (c) 2013 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
C1 [Elnakish, Mohammad T.; Janssen, Paul M.; Angelos, Mark G.; Khan, Mahmood] Ohio State Univ, Dorothy M Davis Heart & Lung Res Inst, Wexner Med Ctr, Columbus, OH 43210 USA.
   [Elnakish, Mohammad T.; Janssen, Paul M.] Ohio State Univ, Dept Physiol & Cell Biol, Wexner Med Ctr, Columbus, OH 43210 USA.
   [Hassanain, Hamdy H.] Ohio State Univ, Dept Anesthesiol, Wexner Med Ctr, Columbus, OH 43210 USA.
   [Angelos, Mark G.; Khan, Mahmood] Ohio State Univ, Dept Emergency Med, Wexner Med Ctr, Columbus, OH 43210 USA.
C3 University System of Ohio; Ohio State University; University System of
   Ohio; Ohio State University; University System of Ohio; Ohio State
   University; University System of Ohio; Ohio State University
RP Khan, M (corresponding author), Ohio State Univ, Dept Emergency Med, Wexner Med Ctr, 420 West 12th Ave,Room 110, Columbus, OH 43210 USA.
EM mahmood.khan@osumc.edu
RI Janssen, Paul/E-3307-2011; Angelos, Mark/C-9404-2009
OI Khan, Mahmood/0000-0003-3430-374X; Janssen, Paul/0000-0002-9682-3014
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NR 108
TC 108
Z9 120
U1 1
U2 39
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-3417
EI 1096-9896
J9 J PATHOL
JI J. Pathol.
PD NOV
PY 2013
VL 231
IS 3
BP 290
EP 300
DI 10.1002/path.4255
PG 11
WC Oncology; Pathology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Pathology
GA 232FG
UT WOS:000325476500002
PM 24037780
DA 2025-06-11
ER

PT J
AU Tyrka, AR
   Burgers, DE
   Philip, NS
   Price, LH
   Carpenter, LL
AF Tyrka, A. R.
   Burgers, D. E.
   Philip, N. S.
   Price, L. H.
   Carpenter, L. L.
TI The neurobiological correlates of childhood adversity and implications
   for treatment
SO ACTA PSYCHIATRICA SCANDINAVICA
LA English
DT Article
DE early-life stress; childhood abuse; neurobiology; treatment
ID POSTTRAUMATIC-STRESS-DISORDER; DIALECTICAL BEHAVIOR-THERAPY; MAJOR
   DEPRESSIVE DISORDER; PITUITARY-ADRENAL AXIS; EARLY-LIFE STRESS;
   NEUROTROPHIC FACTOR; GLUCOCORTICOID-RECEPTOR; ADJUNCTIVE THERAPY;
   METABOLIC SYNDROME; ANXIETY DISORDERS
AB ObjectiveThis article provides an overview of research on the neurobiological correlates of childhood adversity and a selective review of treatment implications.
   MethodFindings from a broad array of human and animal studies of early adversity were reviewed.
   ResultsTopics reviewed include neuroendocrine, neurotrophic, neuroimaging, and cognitive effects of adversity, as well as genetic and epigenetic influences. Effects of early-life stress on treatment outcome are considered, and development of treatments designed to address the neurobiological abnormalities is discussed.
   ConclusionEarly adversity is associated with abnormalities of several neurobiological systems that are implicated in the development of psychopathology and other medical conditions. Early-life stress negatively impacts treatment outcome, and individuals may require treatments that are specific to this condition.
C1 [Tyrka, A. R.; Burgers, D. E.; Philip, N. S.; Price, L. H.; Carpenter, L. L.] Butler Hosp, Mood Disorders Res Program, Providence, RI 02906 USA.
   [Tyrka, A. R.; Burgers, D. E.; Philip, N. S.; Price, L. H.; Carpenter, L. L.] Butler Hosp, Lab Clin & Translat Neurosci, Providence, RI 02906 USA.
   [Tyrka, A. R.; Philip, N. S.; Price, L. H.; Carpenter, L. L.] Brown Univ, Dept Psychiat & Human Behav, Alpert Med Sch, Providence, RI 02912 USA.
C3 Butler Hospital Rhode Island; Butler Hospital Rhode Island; Brown
   University
RP Tyrka, AR (corresponding author), Butler Hosp, 345 Blackstone Blvd, Providence, RI 02906 USA.
EM Audrey_Tyrka@Brown.edu
RI Tyrka, Audrey/L-2504-2014; Philip, Noah/C-3714-2016
OI Tyrka, Audrey/0000-0003-4653-1651; Burgers, Darcy/0000-0002-3503-2198;
   Philip, Noah/0000-0002-4889-8775
FU National Institute of Mental Health [R01 MH083704, R21 MH091508, R01
   MH068767-01]
FX Supported by National Institute of Mental Health grants R01 MH083704
   (ART), R21 MH091508 (ART), and R01 MH068767-01 (LLC).
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NR 107
TC 102
Z9 118
U1 1
U2 35
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0001-690X
EI 1600-0447
J9 ACTA PSYCHIAT SCAND
JI Acta Psychiatr. Scand.
PD DEC
PY 2013
VL 128
IS 6
BP 434
EP 447
DI 10.1111/acps.12143
PG 14
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 290SQ
UT WOS:000329779000003
PM 23662634
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Bernabé, J
   Mulero, J
   Cerdé, B
   García-Viguera, C
   Moreno, DA
   Parra, S
   Avilés, F
   Gil-Izquierdo, A
   Abellán, J
   Zafrilla, P
AF Bernabe, Juana
   Mulero, Juana
   Cerda, Begona
   Garcia-Viguera, Cristina
   Moreno, Diego A.
   Parra, Soledad
   Aviles, Francisco
   Gil-Izquierdo, Angel
   Abellan, Jose
   Zafrilla, Pilar
TI Effects of a citrus based juice on biomarkers of oxidative stress in
   metabolic syndrome patients
SO JOURNAL OF FUNCTIONAL FOODS
LA English
DT Article
DE Oxidative stress; Metabolic syndrome; Protein carbonyl content;
   15-Isoprostane F-2; 8-OHdG; GSH/GSSH; ox-LDL
ID LOW-DENSITY-LIPOPROTEIN; ARONIA-MELANOCARPA; RISK-FACTORS; ANTIOXIDANT;
   DYSFUNCTION; LDL; MEN; SUPPLEMENTATION; ASSOCIATION; GLUTATHIONE
AB Bioactive substances found in numerous foods can be successfully and safely used to modify various cellular functions and affect the oxidative stress. The aim of this study was to analyze the effect of a citrus-based juice (juice citrus (95%) with 5% of aronia extract (Aronia melanocarpa)) on biomarkers of oxidative stress in patients with metabolic syndrome compared with healthy individuals. The study comprised 20 healthy subjects and 33 patients with metabolic syndrome. Eighteen patients consumed daily 300 mL of a citrus-based juice during 6 months and 15 patients consumed 300 mL of a placebo beverage. The control group consumed a citrus-based juice (CJ). Before, and at sixth months after consuming of a citrus-based juice the following parameters were determined: 15-isoprostane F-2, 8-hydroxydeoxyguanosine (8-OHdG), reduced and oxidized glutathione (GSH/GSSH), carbonyl groups and oxidized LDL (ox-LDL). After consuming CJ during 6 months the values of 8-OHdG, carbonyl groups and LDL-ox decreased in both analyzed groups and the values of GSH/GSSH increased. Significant differences were observed in both groups. Thus consumption of citrus-based juice improved the biomarkers of oxidative stress in metabolic syndrome patients. (C) 2013 Elsevier Ltd. All rights reserved.
C1 [Bernabe, Juana; Mulero, Juana; Cerda, Begona; Zafrilla, Pilar] Catholic Univ San Antonio, Dept Food Technol & Nutr, Murcia 30107, Spain.
   [Garcia-Viguera, Cristina; Moreno, Diego A.; Gil-Izquierdo, Angel] CSIC, CEBAS, Phytochem Lab, Murcia 30100, Spain.
   [Parra, Soledad; Aviles, Francisco] Hosp Univ Virgen de la Arrixaca, Murcia 30120, Spain.
   [Abellan, Jose] Catholic Univ San Antonio, Chair Cardiovasc Risk, Murcia 30107, Spain.
C3 Universidad Catolica de Murcia; Consejo Superior de Investigaciones
   Cientificas (CSIC); CSIC - Centro de Edafologia y Biologia Aplicada del
   Segura (CEBAS); Hospital Clinico Universitario Virgen de la Arrixaca;
   Universidad Catolica de Murcia
RP Zafrilla, P (corresponding author), Catholic Univ San Antonio, Dept Food Technol & Nutr, Murcia 30107, Spain.
EM mpzafrilla@ucam.edu
RI Avilés, Francis/AEB-5532-2022; Zafrilla, Pilar/JAN-5983-2023;
   Gil-Izquierdo, Angel/B-5563-2008; GARCIA-VIGUERA, CRISTINA/B-2153-2012;
   Begona, Cerda/K-5993-2014; Moreno-Fernandez, Diego Angel/G-4379-2011
OI Gil-Izquierdo, Angel/0000-0001-7646-0386; GARCIA-VIGUERA,
   CRISTINA/0000-0002-4751-3917; Begona, Cerda/0000-0003-0385-1145;
   Moreno-Fernandez, Diego Angel/0000-0002-6547-8764; ZAFRILLA,
   PILAR/0000-0002-1463-7120
FU Comision Interministerial de Ciencia y Tecnologia (CICYT)
FX The authors acknowledge the financial support of Comision
   Interministerial de Ciencia y Tecnologia (CICYT).
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   Sjogren P, 2005, ARTERIOSCL THROM VAS, V25, P2580, DOI 10.1161/01.ATV.0000190675.08857.3d
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NR 43
TC 26
Z9 26
U1 1
U2 31
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1756-4646
J9 J FUNCT FOODS
JI J. Funct. Food.
PD JUL
PY 2013
VL 5
IS 3
BP 1031
EP 1038
DI 10.1016/j.jff.2013.02.003
PG 8
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA 195GZ
UT WOS:000322691600003
DA 2025-06-11
ER

PT J
AU Chirinos, DA
   Goldberg, R
   Gellman, M
   Mendez, AJ
   Gutt, M
   McCalla, JR
   Llabre, MM
   Schneiderman, N
AF Chirinos, Diana A.
   Goldberg, Ronald
   Gellman, Marc
   Mendez, Armando J.
   Gutt, Miriam
   McCalla, Judith R.
   Llabre, Maria M.
   Schneiderman, Neil
TI Leptin and its Association with Somatic Depressive Symptoms in Patients
   with the Metabolic Syndrome
SO ANNALS OF BEHAVIORAL MEDICINE
LA English
DT Article
DE Depression; Leptin; Inflammation; Metabolic syndrome; Blood pressure;
   Body weight; Insulin resistance; Lipoproteins; Cardiovascular disease
ID NUTRITION EXAMINATION SURVEY; 1966 BIRTH COHORT; CARDIOVASCULAR
   PROGNOSIS; MYOCARDIAL-INFARCTION; NATIONAL-HEALTH; MOOD DISORDERS;
   YOUNG-ADULTS; RISK-FACTORS; SLEEP-APNEA; DIMENSIONS
AB This study aimed to determine the association between circulating leptin levels and total depressive symptoms as well as depressive symptom dimensions (cognitive and somatic) after controlling for important confounding factors.
   The study sample was comprised of 135 participants with the metabolic syndrome. Depressive symptoms were measured using the Beck Depression Inventory-II. Leptin was measured using a leptin-specific enzyme immunoassay. Inflammation was assessed using C-reactive protein and interleukin-6 levels.
   Leptin was significantly associated with somatic depressive symptoms (beta = 0.33, P = 0.018), but not total depressive symptoms (beta = 0.27, P = 0.067) or cognitive depressive symptoms (beta = 0.21, P = 0.182), after controlling for age, gender, body mass index, and insulin resistance. Further adjustment for C-reactive protein and interleukin-6 levels did not alter the relationship (beta = 0.32, P = 0.023) between circulating leptin levels and somatic depressive symptoms.
   Leptin is independently associated with somatic depressive symptoms in patients with the metabolic syndrome.
C1 [Chirinos, Diana A.; Gellman, Marc; McCalla, Judith R.; Llabre, Maria M.; Schneiderman, Neil] Univ Miami, Dept Psychol, Coral Gables, FL 33124 USA.
   [Goldberg, Ronald; Mendez, Armando J.; Gutt, Miriam] Univ Miami, Miller Sch Med, Dept Med, Miami, FL 33136 USA.
C3 University of Miami; University of Miami
RP Chirinos, DA (corresponding author), Univ Miami, Dept Psychol, POB 248185, Coral Gables, FL 33124 USA.
EM dchirinos-medina@psy.miami.edu
RI Mendez, Armando/HQY-1723-2023
FU NHLBI NIH HHS [T32 HL007426, P01 HL365888, P01 HL036588] Funding Source:
   Medline
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NR 49
TC 27
Z9 29
U1 0
U2 13
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0883-6612
J9 ANN BEHAV MED
JI Ann. Behav. Med.
PD AUG
PY 2013
VL 46
IS 1
BP 31
EP 39
DI 10.1007/s12160-013-9479-5
PG 9
WC Psychology, Multidisciplinary
WE Social Science Citation Index (SSCI)
SC Psychology
GA 180GC
UT WOS:000321580800007
PM 23436275
OA Bronze, Green Accepted
DA 2025-06-11
ER

PT J
AU Pitta, RM
   Kaufmann, O
   Luz, JSN
   Ritti-Dias, RM
   Queiroga, LD
   Wolosker, N
AF Pitta, Rafael Mathias
   Kaufmann, Oskar
   Luz, Julio Silva Nogueira
   Ritti-Dias, Raphael Mendes
   Queiroga, Luana de Lima
   Wolosker, Nelson
TI The association between erectile dysfunction and depression: a
   cross-sectional study of 21,139 Brazilian men
SO EINSTEIN-SAO PAULO
LA English
DT Article
DE Erectile dysfunction; Depression; Exercise; Life style; Obesity
ID URINARY-TRACT SYMPTOMS; STRESS; RELIABILITY; VALIDITY; DISORDER;
   OBESITY; RISK
AB Objective: This study aimed to investigate the relationship between depression and erectile dysfunction while controlling for sociodemographic, physical health, psychological, and lifestyle factors. Additionally, it aimed to compare erectile dysfunction with other clinical, laboratory, and behavioral variables among individuals with depression in the same population. Methods: We included 21,139 men (>= 40 years) who underwent continuous health screening in a quaternary hospital in S & atilde;o Paulo between January 2008 and December 2018. The analysis included laboratory, clinical, and behavioral profile data. Results: The multivariate model indicated that alcohol consumption, perceived stress, lower urinary tract symptoms, erectile dysfunction, body mass index, and triglyceride levels were independent and strong factors associated with depression in men. Additionally, higher levels of physical activity were found to be an independent and strong factor associated with reduced odds of depression in men (all p<0.001). Additionally, depressed men had a higher body mass index (28.50 +/- 4.35 versus 27.65 +/- 3.93kg/m(2), p=0.003), and increased prevalence of hypertension, diabetes mellitus, lower urinary tract symptoms, metabolic syndrome, nonalcoholic fatty liver, sedentary physical activity levels, active tobacco use, risk of alcohol consumption, and perceived stress. Conclusion: Erectile dysfunction was an independent and strong factor associated with depression in Brazilian men, highlighting the need for integrated treatment approaches addressing both conditions.
C1 [Pitta, Rafael Mathias; Kaufmann, Oskar; Luz, Julio Silva Nogueira; Queiroga, Luana de Lima; Wolosker, Nelson] Hosp Israelita Albert Einstein, Fac Israelita Ciencias Saude Albert Einstein, Postgrad Program Hlth Sci, Sao Paulo, SP, Brazil.
   [Ritti-Dias, Raphael Mendes] Univ Nove Julho, Postgrad Program Rehabil Sci, Sao Paulo, SP, Brazil.
   [Wolosker, Nelson] Univ Sao Paulo, Fac Med, Sao Paulo, SP, Brazil.
   [Wolosker, Nelson] Hosp Israelita Albert Einstein, Sao Paulo, SP, Brazil.
C3 Hospital Israelita Albert Einstein; Universidade Nove de Julho;
   Universidade de Sao Paulo; Hospital Israelita Albert Einstein
RP Pitta, RM (corresponding author), Rua Arapa,131 Room 44, BR-04363060 Sao Paulo, SP, Brazil.
EM prof.rafaelpitta@gmail.com
RI WOLOSKER, NELSON/E-2591-2013; Pitta, Rafael/KGK-8404-2024; Ritti-Dias,
   Raphael/G-4200-2013; Kaufmann, Oskar/J-3014-2013
OI Mathias Pitta, Rafael/0000-0003-2341-4698; WOLOSKER,
   NELSON/0000-0003-1991-3507; Ritti-Dias, Raphael/0000-0001-7883-6746;
   Kaufmann, Oskar/0000-0002-6060-4805; Luz, Julio/0009-0009-2340-0158
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NR 29
TC 1
Z9 1
U1 1
U2 1
PU INST ISRAELITA ENSINO & PESQUISA ALBERT EINSTEIN
PI SAO PAULO SP
PA AVENIDA ALBERT EINSTEIN, 627 701, SAO PAULO SP, 05651-901, BRAZIL
SN 1679-4508
EI 2317-6385
J9 EINSTEIN-SAO PAULO
JI Einstein
PY 2024
VL 22
AR eAO1063
DI 10.31744/einstein_journal/2024AO1063
PG 9
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA O4K5L
UT WOS:001370837500019
PM 39699403
OA gold
DA 2025-06-11
ER

PT J
AU Edwards, EM
   Stuver, SO
   Heeren, TC
   Fredman, L
AF Edwards, Erika M.
   Stuver, Sherri O.
   Heeren, Timothy C.
   Fredman, Lisa
TI Job Strain and Incident Metabolic Syndrome Over 5 Years of Follow-Up
   The Coronary Artery Risk Development in Young Adults Study
SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
LA English
DT Article
ID MIDDLE-AGED MEN; HEART-DISEASE; PSYCHOSOCIAL FACTORS; WHITEHALL-II;
   SHIFT-WORK; OBESITY; STRESS; HEALTH; DEMANDS; WOMEN
AB Background: Theories of stress-induced metabolic syndrome predict that job strain would increase risk. Few studies have evaluated this association. Objective: To evaluate the association between job strain and the risk of metabolic syndrome. Methods: We investigated associations between job strain and incident metabolic syndrome adjusted for sociodemographic factors, health behaviors, and depressive symptoms over 5 years among 2966 black and white men and women in the Coronary Artery Risk Development in Young Adults study. Job strain was categorized by Karasek's model: high demands/low control; high demands/high control; low demands/low control; and low demands/high control. Results: Compared with persons in low-strain jobs, men in active jobs (adjusted hazards ratio, 2.7; 95% confidence interval, 1.5 to 4.9) and women in high strain jobs (adjusted hazards ratio, 2.2; 95% confidence interval, 1.0 to 4.6) had significantly increased risk of metabolic syndrome. Conclusion: Job strain may be a modifiable risk factor for metabolic syndrome and subsequent cardiovascular disease.
C1 [Edwards, Erika M.] Univ Vermont, Dept Math & Stat, Burlington, VT 05405 USA.
   [Stuver, Sherri O.; Fredman, Lisa] Boston Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA USA.
   [Heeren, Timothy C.] Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA USA.
C3 University of Vermont; Boston University; Boston University
RP Edwards, EM (corresponding author), Univ Vermont, Dept Math & Stat, 16 Colchester Ave, Burlington, VT 05405 USA.
EM erika.edwards@uvm.edu
OI Heeren, Timothy/0000-0001-5643-3559; Stuver, Sherri/0000-0002-4027-2663;
   Fredman, Lisa/0000-0001-5341-2955
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NR 33
TC 34
Z9 35
U1 0
U2 25
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1076-2752
J9 J OCCUP ENVIRON MED
JI J. Occup. Environ. Med.
PD DEC
PY 2012
VL 54
IS 12
BP 1447
EP 1452
DI 10.1097/JOM.0b013e3182783f27
PG 6
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA 050PV
UT WOS:000312067400003
PM 23171915
DA 2025-06-11
ER

EF﻿FN Clarivate Analytics Web of Science
VR 1.0
PT J
AU Spiga, R
   Marini, MA
   Mancuso, E
   Di Fatta, C
   Fuoco, A
   Perticone, F
   Andreozzi, F
   Mannino, GC
   Sesti, G
AF Spiga, Rosangela
   Marini, Maria Adelaide
   Mancuso, Elettra
   Di Fatta, Concetta
   Fuoco, Anastasia
   Perticone, Francesco
   Andreozzi, Francesco
   Mannino, Gaia Chiara
   Sesti, Giorgio
TI Uric Acid Is Associated With Inflammatory Biomarkers and Induces
   Inflammation Via Activating the NF-κB Signaling Pathway in HepG2 Cells
SO ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
LA English
DT Article
DE inflammation; NF-kappa B; oxidative stress; risk factors; uric acid
ID C-REACTIVE PROTEIN; CARDIOVASCULAR-DISEASE; ENDOTHELIAL DYSFUNCTION;
   ESSENTIAL-HYPERTENSION; METABOLIC SYNDROME; POSTMENOPAUSAL WOMEN;
   INSULIN-RESISTANCE; HYDROGEN-PEROXIDE; OXIDATIVE STRESS; NITRIC-OXIDE
AB Objective-Serum uric acid (UA) has been associated with increased risk of cardiovascular and metabolic diseases. However, the causal mechanisms linking elevated UA levels to cardio-metabolic diseases are still unsettled. One potential explanation for how UA might contribute to cardio-metabolic disease might be its ability to induce systemic inflammation.
   Approach and Results-Herein, we report a positive relationship between serum UA and acute-phase reactants, such as highsensitivity C-reactive protein, fibrinogen, ferritin, complement C3, and erythrocyte sedimentation rate, in a cohort of 2731 nondiabetic adults. The relationship remains significant after adjustment for several confounders, including age, sex, adiposity, anti-hypertensive treatments or diuretics use. To confirm the existence of a causal relationship, we examined the effect of UA on the expression of inflammatory biomarkers in human hepatoma HepG2 cells and characterized the signaling pathway by which UA acts. We show that UA stimulates the expression of C-reactive protein, fibrinogen, ferritin, and complement C3 in a dose-dependent fashion. The proinflammatory effects of UA were abrogated by benzbromarone, a specific inhibitor of UA transporters. Exposure of cells to UA resulted in activation of the I.B kinase/I.Ba/NF-kappa B signaling pathway that was attenuated by benzbromarone. The effect of UA was completely blocked by the antioxidant N-acetylcysteine.
   Conclusions-These in vivo and in vitro data suggest that hyperuricemia might induce the expression of hepatic inflammatory molecules by activating the proinflammatory NF-kappa B signaling cascade. Because inflammation has an important pathogenetic role in metabolic and cardiovascular disease, our study may help understanding the mechanism by which hyperuricemia may contribute to organ damage.
C1 [Spiga, Rosangela; Mancuso, Elettra; Di Fatta, Concetta; Fuoco, Anastasia; Perticone, Francesco; Andreozzi, Francesco; Mannino, Gaia Chiara; Sesti, Giorgio] Magna Graecia Univ Catanzaro, Dept Med & Surg Sci, Catanzaro, Italy.
   [Marini, Maria Adelaide] Univ Roma Tor Vergata, Dept Syst Med, Rome, Italy.
C3 Magna Graecia University of Catanzaro; University of Rome Tor Vergata
RP Mannino, GC (corresponding author), Magna Graecia Univ Catanzaro, Dipartimento Sci Med & Chirurg, Viale Europa, I-88100 Catanzaro, Italy.
EM gaiamannino@gmail.com
RI Sesti, Giorgio/B-1509-2012; Spiga, Rosangela/AAB-4421-2020; Mancuso,
   Elettra/AAD-5180-2020; Perticone, Francesco/I-4260-2017; Andreozzi,
   Francesco/J-4073-2018; Mannino, Gaia Chiara/K-1580-2016
OI Andreozzi, Francesco/0000-0001-9375-1513; Mannino, Gaia
   Chiara/0000-0002-6341-4572; Spiga, Rosangela/0000-0002-3331-6568;
   Mancuso, Elettra/0000-0002-0562-9196
FU Foundation for Diabetes Research of the Italian Diabetes Society (SID),
   through the award of "Fondazione Diabete Ricerca FO.DI.RI.-MSD"
   scholarships
FX This work was supported, in part, by the Foundation for Diabetes
   Research of the Italian Diabetes Society (SID), through the award of
   "Fondazione Diabete Ricerca FO.DI.RI.-MSD" scholarships in 2014 and 2015
   to Gaia Chiara Mannino.
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NR 41
TC 150
Z9 162
U1 2
U2 36
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1079-5642
EI 1524-4636
J9 ARTERIOSCL THROM VAS
JI Arterioscler. Thromb. Vasc. Biol.
PD JUN
PY 2017
VL 37
IS 6
BP 1241
EP +
DI 10.1161/ATVBAHA.117.309128
PG 11
WC Hematology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Hematology; Cardiovascular System & Cardiology
GA EV7HY
UT WOS:000401947700031
PM 28408375
OA Bronze
DA 2025-06-11
ER

PT J
AU Nduhirabandi, F
   Du Toit, EF
   Blackhurst, D
   Marais, D
   Lochner, A
AF Nduhirabandi, Frederic
   Du Toit, Eugene F.
   Blackhurst, Dee
   Marais, David
   Lochner, Amanda
TI Chronic melatonin consumption prevents obesity-related metabolic
   abnormalities and protects the heart against myocardial ischemia and
   reperfusion injury in a prediabetic model of diet-induced obesity
SO JOURNAL OF PINEAL RESEARCH
LA English
DT Article
DE antioxidant; cardioprotection; diet-induced obesity; insulin resistance;
   melatonin; myocardial ischemia; reperfusion injury; prediabetic
ID LOW-DENSITY-LIPOPROTEIN; OXIDATIVE STRESS; INSULIN-RESISTANCE; PLASMA
   LEPTIN; BODY-WEIGHT; CARDIOVASCULAR-DISEASES; LIPID HYDROPEROXIDE;
   UNIFYING HYPOTHESIS; PAPILLARY-MUSCLE; REACTIVE OXYGEN
AB Obesity, a major risk factor for ischemic heart disease, is associated with increased oxidative stress and reduced antioxidant status. Melatonin, a potent free radical scavenger and antioxidant, has powerful cardioprotective effects in lean animals but its efficacy in obesity is unknown. We investigated the effects of chronic melatonin administration on the development of the metabolic syndrome as well as ischemia-reperfusion injury in a rat model of diet-induced obesity (DIO). Male Wistar rats received a control diet, a control diet with melatonin, a high-calorie diet, or a high-calorie diet with melatonin (DM). Melatonin (4 mg/kg/day) was administered in the drinking water. After 16 wk, biometric and blood metabolic parameters were measured. Hearts were perfused ex vivo for the evaluation of myocardial function, infarct size (IFS) and biochemical changes [activation of PKB/Akt, ERK, p38 MAPK, AMPK, and glucose transporter (GLUT)-4 expression). The high-calorie diet caused increases in body weight (BW), visceral adiposity, serum insulin and triglycerides (TRIG), with no change in glucose levels. Melatonin treatment reduced the BW gain, visceral adiposity, blood TRIG, serum insulin, homeostatic model assessment index and thiobarbituric acid reactive substances in the DIO group. Melatonin reduced IFS in DIO and control groups and increased percentage recovery of functional performance of DIO hearts. During reperfusion, hearts from melatonin-treated rats had increased activation of PKB/Akt, ERK42/44 and reduced p38 MAPK activation. Chronic melatonin treatment prevented the metabolic abnormalities induced by DIO and protected the heart against ischemia-reperfusion injury. These beneficial effects were associated with activation of the reperfusion injury salvage kinases pathway.
C1 [Nduhirabandi, Frederic; Lochner, Amanda] Univ Stellenbosch, Fac Hlth Sci, Dept Biomed Sci, Div Med Physiol, ZA-7600 Stellenbosch, South Africa.
   [Du Toit, Eugene F.] Griffith Univ, Sch Med Sci, Nathan, Qld 4111, Australia.
   [Blackhurst, Dee; Marais, David] Univ Cape Town, Dept Internal Med, Div Lipidol, ZA-7925 Cape Town, South Africa.
C3 Stellenbosch University; Griffith University; University of Cape Town
RP Lochner, A (corresponding author), Fac Hlth Sci, Dept Biomed Sci, POB 19063, ZA-7505 Tygerberg, South Africa.
EM alo@sun.ac.za
RI Nduhirabandi, Frederic/M-6274-2018
OI Nduhirabandi, Frederic/0000-0002-0428-1220
FU South African National Reseach Foundation
FX We would like to thank Mrs S. Genade and Mr W. Smith for excellent
   technical assistance. This study was supported by the South African
   National Reseach Foundation.
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NR 76
TC 113
Z9 123
U1 0
U2 11
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0742-3098
EI 1600-079X
J9 J PINEAL RES
JI J. Pineal Res.
PD MAR
PY 2011
VL 50
IS 2
BP 171
EP 182
DI 10.1111/j.1600-079X.2010.00826.x
PG 12
WC Endocrinology & Metabolism; Neurosciences; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Physiology
GA 719YH
UT WOS:000287246900008
PM 21073520
OA Bronze
DA 2025-06-11
ER

PT J
AU Kelishadi, R
   Hashemi, M
   Mohammadifard, N
   Asgary, S
   Khavarian, N
AF Kelishadi, Roya
   Hashemi, Mohammad
   Mohammadifard, Noushin
   Asgary, Sedigheh
   Khavarian, Noushin
TI Association of changes in oxidative and proinflammatory states with
   changes in vascular function after a lifestyle modification trial among
   obese children
SO CLINICAL CHEMISTRY
LA English
DT Article
ID INTIMA-MEDIA THICKNESS; LOW-DENSITY-LIPOPROTEIN; DISEASE RISK-FACTORS;
   C-REACTIVE PROTEIN; CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME;
   ANTHROPOMETRIC INDEXES; ENDOTHELIAL FUNCTION; INSULIN-RESISTANCE;
   WEIGHT-REDUCTION
AB BACKGROUND: The association of changes in oxidative and proinflammatory states with vascular function after diet and exercise intervention among obese children has not been previously explored.
   METHODS: In this 6-week diet and exercise intervention study in 35 obese children, age 12 to 18 years, we evaluated the relationship between changes in anthropometric indices, measures of insulin resistance, C-reactive protein (CRP), oxidized LDL (ox-LDL), and oxidative stress markers with changes in carotid intima-media thickness (C-IMT) and flow mediated dilation (FMD) of the brachial artery.
   RESULTS: At the end of the study, body mass index (BMI), waist circumference, and percentage body fat were decreased (P <0.05), but participants remained over-weight (BMI >= 95th percentile). Although FMD improved (P <0.05), the improvement in C-IMT did not reach statistical significance. The changes in BMI, waist circumference, fat mass, ox-LDL, malondialdehyde (MDA), CRP, insulin, and homeostasis model assessment for insulin resistance (HOMA-IR) had an inverse correlation with the changes in mean FMD after adjustment for age and sex, with the highest correlations documented for ox-LDL, CRP, and WC. The age-and sex-adjusted changes in ox-LDL, waist circumference, CRP, MDA, and body fat mass had the highest correlations with changes in C-IMT.
   CONCLUSIONS: Our findings suggest that a common inflammatory stress condition associated with childhood obesity, notably with abdominal fat deposition, may play a role in the development of the earliest stages of proatherosclerotic inflammatory processes and subsequent vascular dysfunction. These changes might be partially reversible by short-term diet and exercise intervention, even if patients do not reach ideal body weight. (c) 2007 American Association for Clinical Chemistry.
C1 [Kelishadi, Roya; Khavarian, Noushin] Isfahan Univ Med Sci, Isfahan Cardiovasc Res Ctr, Prevent Pediat Cardiol Dept, Esfahan, Iran.
   [Hashemi, Mohammad] Isfahan Univ Med Sci, Isfahan Sch Med, Esfahan, Iran.
   [Mohammadifard, Noushin] Isfahan Univ Med Sci, Isfahan Cardiovasc Res Ctr, Dept Nutr, Esfahan, Iran.
   [Asgary, Sedigheh] Isfahan Univ Med Sci, Isfahan Cardiovasc Res Ctr, Dept Basic Sci, Esfahan, Iran.
C3 Isfahan University of Medical Sciences; Isfahan University of Medical
   Sciences; Isfahan University of Medical Sciences; Isfahan University of
   Medical Sciences
RP Kelishadi, R (corresponding author), Isfahan Univ Med Sci, Isfahan Cardiovasc Res Ctr, Prevent Pediat Cardiol Dept, WHO Collaborating Ctr EMR, POB 81465-1148, Esfahan, Iran.
EM kroya@aap.net
RI Mohammadifard, Noushin/M-2244-2018; Kelishadi, Roya/E-6154-2012
OI Kelishadi, Roya/0000-0001-7455-1495
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NR 39
TC 100
Z9 115
U1 0
U2 5
PU AMER ASSOC CLINICAL CHEMISTRY
PI WASHINGTON
PA 2101 L STREET NW, SUITE 202, WASHINGTON, DC 20037-1526 USA
SN 0009-9147
EI 1530-8561
J9 CLIN CHEM
JI Clin. Chem.
PD JAN
PY 2008
VL 54
IS 1
BP 147
EP 153
DI 10.1373/clinchem.2007.089953
PG 7
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA 250JJ
UT WOS:000252295600023
PM 17998270
OA Bronze
DA 2025-06-11
ER

PT J
AU Mengen, E
   Uçaktürk, SA
   Kocaay, P
   Kaymaz, Ö
   Neselioglu, S
   Erel, O
AF Mengen, Eda
   Ucakturk, Seyit Ahmet
   Kocaay, Pinar
   Kaymaz, Ozlem
   Neselioglu, Salim
   Erel, Ozcan
TI The Significance of Thiol/Disulfide Homeostasis and Ischemia- modified
   Albumin Levels in Assessing Oxidative Stress in Obese Children and
   Adolescents
SO JOURNAL OF CLINICAL RESEARCH IN PEDIATRIC ENDOCRINOLOGY
LA English
DT Article
DE Obesity; children and adolescents; thiol/disulfide homeostasis;
   ischemia-modified albumin
ID REDUCED ANTIOXIDANT CAPACITY; THIOL-DISULFIDE HOMEOSTASIS; TYPE-2
   DIABETES-MELLITUS; CHILDHOOD OBESITY; INFLAMMATION MARKERS;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; PUBERTAL CHANGES; PLASMA;
   GLUTATHIONE
AB Objective: There is an association between obesity and several inflammatory and oxidative markers in children. In this study, we analyzed thiol/disulfide homeostasis and serum ischemia-modified albumin (IMA) levels for the first time in order to clarify and determine the oxidant/antioxidant balance in metabolically healthy and unhealthy children.
   Methods: This study included obese children and healthy volunteers between 4-18 years of age. The obese patients were divided into two groups: metabolically healthy obese (MHO) and metabolically unhealthy obese (MUO). Biochemical parameters including thiol/disulfide homeostasis, and IMA concentrations were analyzed.
   Results: There were 301 recruits of whom 168 (55.8 %) were females. The obese children numbered 196 (MHO n = 58 and MUO n = 138) and healthy controls numbered 105. No statistically significant difference could be found in ages and genders of the patients among all groups (p > 0.05, for all). Native thiol (SH), total thiol (SH +SS), and native thiol/total thiol (SH/SH +SS) ratio were statistically significantly lower in the MUO group than the control group (p <0.001, p = 0.005, and p = 0.005; respectively). Disulfide (SS), disulfide/native thiol (SS/SH), disulfide/total thiol (SS/SH + SS) and IMA levels were statistically significantly higher in the MUO group than the control group (p = 0.002, p < 0.001, p < 0.001, and p = 0.001, respectively).
   Conclusion: Chronic inflammation due to oxidative stress induced by impaired metabolic parameters in MUO children caused impairment in thiol redox homeostasis. Our data suggested that the degree of oxidant imbalance in obese children worsened as obesity and metabolic abnormalities increased. It is hypothesized that thiol/disulfide homeostasis and high serum IMA levels may be reliable indicators of oxidant-antioxidant status in MUO children.
C1 [Mengen, Eda; Ucakturk, Seyit Ahmet; Kocaay, Pinar] Ankara City Hosp, Childrens Hosp, Clin Pediat Endocrinol, Ankara, Turkey.
   [Kaymaz, Ozlem] Ankara Univ, Fac Med, Dept Stat, Ankara, Turkey.
   [Neselioglu, Salim; Erel, Ozcan] Yildirim Beyazit Univ, Dept Biochem, Fac Med, Ankara, Turkey.
C3 City Hospital Ankara; Ankara University; Ankara Yildirim Beyazit
   University
RP Mengen, E (corresponding author), Ankara City Hosp, Childrens Hosp, Clin Pediat Endocrinol, Ankara, Turkey.
EM drmengen@hotmail.com
RI EREL, Ozcan/U-1008-2019; kocaay, pinar/KIB-8181-2024; GÜLLÜ,
   Özlem/AAI-5566-2020; neselioglu, salim/F-6853-2013; UCAKTURK, Seyit
   Ahmet/HKV-9301-2023
OI EREL, Ozcan/0000-0002-2996-3236; Mengen, Eda/0000-0003-1597-8418;
   kocaay, pinar/0000-0003-0850-0360; neselioglu,
   salim/0000-0002-0974-5717; UCAKTURK, Seyit Ahmet/0000-0001-8666-4454
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NR 55
TC 9
Z9 10
U1 1
U2 6
PU GALENOS YAYINCILIK
PI FINDIKZADE
PA MOLLA GURANI MAHALLESI KACAMAK SOKAK NO 21, FINDIKZADE, ISTANBUL 34093,
   TURKEY
SN 1308-5727
EI 1308-5735
J9 J CLIN RES PEDIATR E
JI J. Clin Res. Pediatr. Endocrinol.
PD MAR
PY 2020
VL 12
IS 1
BP 45
EP 54
DI 10.4274/jcrpe.galenos.2019.2019.0039
PG 10
WC Endocrinology & Metabolism; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Pediatrics
GA KW3NO
UT WOS:000521073900005
PM 31414586
OA gold, Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Zhang, X
   Zhang, JH
   Chen, XY
   Hu, QH
   Wang, MX
   Jin, R
   Zhang, QY
   Wang, W
   Wang, R
   Kang, LL
   Li, JS
   Li, M
   Pan, Y
   Huang, JJ
   Kong, LD
AF Zhang, Xian
   Zhang, Jian-Hua
   Chen, Xu-Yang
   Hu, Qing-Hua
   Wang, Ming-Xing
   Jin, Rui
   Zhang, Qing-Yu
   Wang, Wei
   Wang, Rong
   Kang, Lin-Lin
   Li, Jin-Sheng
   Li, Meng
   Pan, Ying
   Huang, Jun-Jian
   Kong, Ling-Dong
TI Reactive Oxygen Species-Induced TXNIP Drives Fructose-Mediated Hepatic
   Inflammation and Lipid Accumulation Through NLRP3 Inflammasome
   Activation
SO ANTIOXIDANTS & REDOX SIGNALING
LA English
DT Article
ID FATTY LIVER-DISEASE; THIOREDOXIN-INTERACTING PROTEIN; OXIDATIVE STRESS;
   NONALCOHOLIC STEATOHEPATITIS; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   ISCHEMIA-REPERFUSION; DIETARY FRUCTOSE; KUPFFER CELLS; HEPG2 CELLS
AB Aims: Increased fructose consumption predisposes the liver to nonalcoholic fatty liver disease (NAFLD), but the mechanisms are elusive. Thioredoxin-interacting protein (TXNIP) links oxidative stress to NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome activation and this signaling axis may be involved in fructose-induced NAFLD. Here, we explore the role of reactive oxygen species (ROS)-induced TXNIP overexpression in fructose-mediated hepatic NLRP3 inflammasome activation, inflammation, and lipid accumulation. Results: Rats were fed a 10% fructose diet for 8 weeks and treated with allopurinol and quercetin during the last 4 weeks. Five millimolars of fructose-exposed hepatocytes (primary rat hepatocytes, rat hepatic parenchymal cells [RHPCs], HLO2, HepG2) were co-incubated with antioxidants or caspase-1 inhibitor or subjected to TXNIP or NLRP3 siRNA interference. Fructose induced NLRP3 inflammasome activation and pro-inflammatory cytokine secretion, janus-activated kinase 2/signal transducers and activators of transcription 3-mediated inflammatory signaling, and expression alteration of lipid metabolism-related genes in cultured hepatocytes and rat livers. NLRP3 silencing and caspase-1 suppression blocked these effects in primary rat hepatocytes and RHPCs, confirming that inflammasome activation alters hepatocyte lipid metabolism. Hepatocellular ROS and TXNIP were increased in animal and cell models. TXNIP silencing blocked NLRP3 inflammasome activation, inflammation, and lipid metabolism perturbations but not ROS induction in fructose-exposed hepatocytes, whereas antioxidants addition abrogated TXNIP induction and diminished the detrimental effects in fructose-exposed hepatocytes and rat livers. Innovation and Conclusions: This study provides a novel mechanism for fructose-induced NAFLD pathogenesis by which the ROS-TXNIP pathway mediates hepatocellular NLRP3 inflammasome activation, inflammation and lipid accumulation. Antioxidant-based interventions can inhibit the ROS-TXNIP pathway. Antioxid. Redox Signal. 22, 848-870.
C1 [Zhang, Xian; Zhang, Jian-Hua; Chen, Xu-Yang; Hu, Qing-Hua; Wang, Ming-Xing; Zhang, Qing-Yu; Wang, Wei; Wang, Rong; Kang, Lin-Lin; Li, Jin-Sheng; Li, Meng; Pan, Ying; Kong, Ling-Dong] Nanjing Univ, Sch Life Sci, State Key Lab Pharmaceut Biotechnol, Nanjing 210093, Jiangsu, Peoples R China.
   [Jin, Rui; Huang, Jun-Jian] Beijing Inst Biotechnol, Lab Tumor & Mol Biol, Beijing 100850, Peoples R China.
C3 Nanjing University
RP Kong, LD (corresponding author), Nanjing Univ, Sch Life Sci, State Key Lab Pharmaceut Biotechnol, 22 Hankou Rd, Nanjing 210093, Jiangsu, Peoples R China.
EM pany@nju.edu.cn; junjianhuangbit@163.com; kongld@nju.edu.cn
RI jin, rui/KHW-6854-2024; w, w/J-6981-2019; Hu, Qinghua/KJM-2223-2024;
   Huang, Jian/GYJ-5213-2022; Chen, Xuyang/JEO-6530-2023
OI Jinsheng, Li/0000-0002-5293-1590
FU National Basic Research Program of China 973 Program [2012CB517600,
   2012CB517602]; Natural Science Foundation of China [81025025, 81373788,
   J1103512]; PhD Programs Foundation of the Ministry of Education of China
   [20120091110039]
FX This work has been supported by grants from the National Basic Research
   Program of China 973 Program No. 2012CB517600 (No. 2012CB517602) and the
   Natural Science Foundation of China (No. 81025025, 81373788, and
   J1103512). Support was also obtained from the PhD Programs Foundation of
   the Ministry of Education of China (20120091110039).
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NR 64
TC 202
Z9 214
U1 5
U2 107
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1523-0864
EI 1557-7716
J9 ANTIOXID REDOX SIGN
JI Antioxid. Redox Signal.
PD APR 1
PY 2015
VL 22
IS 10
BP 848
EP 870
DI 10.1089/ars.2014.5868
PG 23
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA CD5US
UT WOS:000351154200004
PM 25602171
OA Green Published
DA 2025-06-11
ER

PT J
AU Yamaguchi, Y
   Moriki, T
   Igari, A
   Matsubara, Y
   Ohnishi, T
   Hosokawa, K
   Murata, M
AF Yamaguchi, Yusuke
   Moriki, Takanori
   Igari, Atsuko
   Matsubara, Yumiko
   Ohnishi, Tomoko
   Hosokawa, Kazuya
   Murata, Mitsuru
TI Studies of a microchip flow-chamber system to characterize whole blood
   thrombogenicity in healthy individuals
SO THROMBOSIS RESEARCH
LA English
DT Article
DE Thrombus formation; Platelet; Flow-chamber system; Thrombogenicity
ID PLATELET THROMBUS FORMATION; METABOLIC SYNDROME; ARTERIAL THROMBOSIS;
   CARDIOVASCULAR RISK; VIRCHOWS TRIAD; HEART-DISEASE; SHEAR-STRESS;
   HEMOSTASIS; AGGREGATION; ACTIVATION
AB Introduction: A whole blood flow-chamber system, the Total Thrombus-formation Analysis System (T-TAS), was developed for quantitative analysis of platelet thrombus formation (PTF) using microchips with thrombogenic surfaces (collagen, PL chip; collagen plus tissue thromboplastin, AR chip) under shear stress conditions. We evaluated the usefulness of the T-TAS for assessing individual thrombogenicity compared with other platelet function tests.
   Materials and Methods: Blood samples from 31 healthy volunteers were applied to the T-TAS to measure PTF starting time (T-10: time to reach 10 kPa), occlusion time (T-60 for PL chip; T-80 for AR chip), and area under the curve (AUC(10), area under curve until 10 min for PL chip; AUC(30), 30 min for AR chip) under various shear rates (1000, 1500, 2000 s(-1) for PL chip; 300 s(-1) for AR chip). Platelet functions were also tested using platelet aggregometry, the PFA-100 (collagen and epinephrine [C/EPI], collagen and adenosine diphosphate [C/ADP]), and the VerifyNow P2Y12 assay.
   Results: Individual pressure waveforms, including PTF starting and ending points, varied among healthy subjects. In the PL chip, T-10 and AUC(10) showed a shear-dependent correlation with C/EPI or C/ADP. VerifyNow P2Y12 values were not significantly associated with the parameters of the T-TAS. Platelet counts were correlated with all AR measurements, and mostly with PL measurements.
   Conclusion: The results of the T-TAS were associated with those of the PFA-100 in many respects, indicating that its characteristics are related to shear-induced PTF. The T-TAS showed few correlations with platelet aggregometry and the VerifyNow P2Y12 assay. The T-TAS may allow for the measurement of comprehensive parameters of individual thrombogenicity under whole blood flow conditions. (c) 2013 Elsevier Ltd. All rights reserved.
C1 [Yamaguchi, Yusuke; Igari, Atsuko; Matsubara, Yumiko; Murata, Mitsuru] Keio Univ, Sch Med, Dept Lab Med, Tokyo 1608582, Japan.
   [Moriki, Takanori] Keio Univ, Ctr Hlth, Shinjuku Ku, Tokyo 1608582, Japan.
   [Ohnishi, Tomoko; Hosokawa, Kazuya] Fujimori Kogyo Co, Res Inst, Yokohama, Kanagawa, Japan.
C3 Keio University; Keio University
RP Moriki, T (corresponding author), Keio Univ, Ctr Hlth, Shinjuku Ku, 35 Shinanomachi, Tokyo 1608582, Japan.
EM TakaMoriki@aol.com
RI Murata, Mitsuru/A-7845-2015
FU Keio Gijuku Academic Development Funds; Ministry of Health, Labor, and
   Welfare of Japan; Ministry of Education, Culture, Sports, Science and
   Technology of Japan
FX This study was supported in part by a grant from Keio Gijuku Academic
   Development Funds (T.M.) and a grant from the Ministry of Health, Labor,
   and Welfare of Japan (M.M), and a grant from Ministry of Education,
   Culture, Sports, Science and Technology of Japan (M.M).
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NR 39
TC 43
Z9 46
U1 0
U2 8
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0049-3848
J9 THROMB RES
JI Thromb. Res.
PD AUG
PY 2013
VL 132
IS 2
BP 263
EP 270
DI 10.1016/j.thromres.2013.05.026
PG 8
WC Hematology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Hematology; Cardiovascular System & Cardiology
GA 213LV
UT WOS:000324059600035
PM 23777751
DA 2025-06-11
ER

PT J
AU Kelishadi, R
   Poursafa, P
   Keramatian, K
AF Kelishadi, Roya
   Poursafa, Parinaz
   Keramatian, Kasra
TI Overweight, air and noise pollution: Universal risk factors for
   pediatric pre-hypertension
SO JOURNAL OF RESEARCH IN MEDICAL SCIENCES
LA English
DT Review
DE Prevention; Blood Pressure; Pre-hypertension; Genetics; Environment;
   Children
ID HIGH BLOOD-PRESSURE; LEFT-VENTRICULAR MASS; STYLE MODIFICATION TRIAL;
   LOW-SALT DIET; PHYSICAL-ACTIVITY; METABOLIC SYNDROME;
   CARDIOVASCULAR-DISEASE; SCIENTIFIC STATEMENT; INSULIN-RESISTANCE;
   LIFE-STYLE
AB Pediatric pre-hypertension (pre-HTN) has a complex multifactorial etiology. Although most cases are secondary to other disorders, a substantial number of children and adolescents have primary or essential HTN and pre-HTN. The gene-gene and gene-environment interactions should be considered in this context. The strong relationship of pre-HTN with environmental factors such as air pollution, noise pollution and passive smoking and obesity suggest that its prevalence will be escalating.
   Exposure to ambient particulate matters may increase blood pressure (BP) within hours to days. The underlying biologic pathways include autonomic nervous system imbalance and arterial vascular dysfunction or vasoconstriction because of systemic oxidative stress and inflammation. Likewise, tobacco smoke exposure of pregnant mothers increases systolic BP of their offspring in early infancy. Parental smoking also independently affects systolic BP among healthy preschool children. Noise exposure, notably in night, is associated with catecholamine secretion, increased BP and a pre-HTN state even in pre-school age children.
   Excess weight is associated with dysfunction of the adipose tissue, consisting of enlarged hypertrophied adipocytes, increased infiltration by macrophages and variations in secretion of adipokines and free fatty acids. These changes would result in chronic vascular inflammation, oxidative stress, activation of the renin-angiotensin-aldosterone system and sympathetic response, and ultimately to pre-HTN from childhood.
   Prevention and control of the modifiable risk factors of pre-HTN from prenatal period can have long-term health impact on primordial and primary prevention of chronic non-communicable diseases. This review presents a general view on the diagnosis, prevalence and etiology of pre-HTN along with practical measures for its prevention and control.
C1 [Poursafa, Parinaz] Isfahan Univ Med Sci, Environm Res Ctr, Esfahan, Iran.
   [Kelishadi, Roya] Isfahan Univ Med Sci, Dept Paediat, Child Hlth Promot Res Ctr, Sch Med, Esfahan, Iran.
C3 Isfahan University of Medical Sciences; Isfahan University of Medical
   Sciences
RP Poursafa, P (corresponding author), Isfahan Univ Med Sci, Environm Res Ctr, Esfahan, Iran.
EM parinaz.poursafa@gmail.com
RI Kelishadi, Roya/E-6154-2012; Poursafa, Parinaz/U-2924-2017
OI Kelishadi, Roya/0000-0001-7455-1495; Poursafa,
   Parinaz/0000-0002-8067-4122
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NR 182
TC 34
Z9 38
U1 2
U2 32
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, Maharashtra, INDIA
SN 1735-1995
EI 1735-7136
J9 J RES MED SCI
JI J. Res. Med. Sci.
PD SEP
PY 2011
VL 16
IS 9
BP 1234
EP 1250
PG 17
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 843LC
UT WOS:000296672300018
PM 22973395
DA 2025-06-11
ER

PT J
AU Syed, I
   Jayaram, B
   Subasinghe, W
   Kowluru, A
AF Syed, Ismail
   Jayaram, Bhavaani
   Subasinghe, Wasanthi
   Kowluru, Anjaneyulu
TI Tiam1/Rac1 signaling pathway mediates palmitate-induced,
   ceramide-sensitive generation of superoxides and lipid peroxides and the
   loss of mitochondrial membrane potential in pancreatic β-cells
SO BIOCHEMICAL PHARMACOLOGY
LA English
DT Article
DE NADPH oxidase; Rac1; Tiam1; Palmitate; Ceramide; Oxidative stress;
   Pancreatic beta-cells
ID NADPH OXIDASE; OXIDATIVE STRESS; NAD(P)H OXIDASE; METABOLIC SYNDROME;
   INSULIN-SECRETION; FATTY-ACIDS; ACTIVATION; DYSFUNCTION; ISLETS;
   APOPTOSIS
AB The phagocytic NADPH oxidase [NOX] has been implicated in the generation of superoxides in the pancreatic beta-cell. Herein, using normal rat islets and clonal INS 832/13 cells, we tested the hypothesis that activation of the small G-protein Rac1, which is a member of the NOX holoenzyme, is necessary for palmitate [PA]-induced generation of superoxides in pancreatic beta-cells Incubation of isolated beta-cells with PA potently increased the NOX activity culminating in a significant increase in the generation of superoxides and lipid peroxides in these cells, such effects of PA were attenuated by diphenyleneio-donium [DPI], a known inhibitor of NOX. In addition, PA caused a transient, but significant activation [i.e. GTP-bound form] of Rac1 in these cells NSC23766. a selective inhibitor of Rac1. but not Cdc42 or Rho activation, inhibited Rac1 activation and the generation of superoxides and lipid peroxides induced by PA. Fumonisin B-1 [FB-1], which inhibits de novo synthesis of ceramide [CER] from PA, also attenuated PA-induced superoxide and lipid peroxide generation and NOX activity implicating intracellularly generated CER in the metabolic effects of PA, such effects were also demonstrable in the presence of the cell-permeable C2-CER. Further, NSC23766 prevented C2-CER-induced Rac1 activation and production of superoxides and lipid peroxides. Lastly, C2-CER, but not its inactive analogue, significantly reduced the mitochondrial membrane potential, which was prevented to a large degree by NSC23766. Together, our findings suggest that Tiam1/Rac1 signaling pathway regulates PA-induced, CER-dependent superoxide generation and mitochondrial dysfunction in pancreatic beta-cells Published by Elsevier Inc
C1 [Syed, Ismail; Jayaram, Bhavaani; Subasinghe, Wasanthi; Kowluru, Anjaneyulu] Wayne State Univ, Eugene Applebaum Coll Pharm, Dept Pharmaceut Sci, Detroit, MI 48201 USA.
   [Syed, Ismail; Jayaram, Bhavaani; Subasinghe, Wasanthi; Kowluru, Anjaneyulu] John D Dingell VA Med Ctr, Cell Biochem Res Lab, Detroit, MI 48201 USA.
C3 Wayne State University
RP Kowluru, A (corresponding author), Wayne State Univ, Eugene Applebaum Coll Pharm & Hlth Sci, Dept Pharmaceut Sci, 259 Mack Ave, Detroit, MI 48201 USA.
OI Subasinghe, Wasanthi/0000-0003-3847-0852; Kowluru,
   Anjaneyulu/0000-0003-1700-0077; SYED, ISMAIL/0000-0002-1941-5957
FU Department of Veterans Affairs; National Institutes of Health [DK
   74921]; Grodman Cure Foundation
FX This research was supported by a Merit Review Award from the Department
   of Veterans Affairs, the National Institutes of Health [DK 74921], and
   the Grodman Cure Foundation. AK is also the recipient of the Senior
   Research Career Scientist Award from the Department of Veterans Affairs.
   The authors acknowledge the excellent technical assistance of Mr Brandon
   Koch in these studies.
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NR 40
TC 57
Z9 63
U1 0
U2 2
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0006-2952
EI 1873-2968
J9 BIOCHEM PHARMACOL
JI Biochem. Pharmacol.
PD SEP 15
PY 2010
VL 80
IS 6
BP 874
EP 883
DI 10.1016/j.bcp.2010.05.006
PG 10
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 635YC
UT WOS:000280692800013
PM 20493824
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Kaditis, A
   Gozal, D
   Snow, AB
   Kheirandish-Gozal, L
   Alexopoulos, E
   Varlami, V
   Papathanasiou, AA
   Capdevila, OS
   Bhattacharjee, R
   Kim, J
   Gourgoulianis, K
   Zintzaras, E
AF Kaditis, Athanasios
   Gozal, David
   Snow, Ayelet B.
   Kheirandish-Gozal, Leila
   Alexopoulos, Emmanouel
   Varlami, Vasiliki
   Papathanasiou, Afroditi A.
   Capdevila, Oscar Sans
   Bhattacharjee, Rakesh
   Kim, Jinkwan
   Gourgoulianis, Konstantinos
   Zintzaras, Elias
TI Uric acid excretion in North American and Southeast European children
   with obstructive sleep apnea
SO SLEEP MEDICINE
LA English
DT Article
DE Hypoxemia; Inflammation; Obstructive sleep apnea; Oxidative stress;
   Sleep-disordered breathing; Uric acid
ID C-REACTIVE PROTEIN; ENDOTHELIAL GROWTH-FACTOR; OXIDATIVE STRESS;
   CREATININE RATIO; BLOOD-PRESSURE; ADHESION MOLECULES; METABOLIC
   SYNDROME; OBESE CHILDREN; INFLAMMATION; ASSOCIATION
AB Background and objectives: Responses to nocturnal hypoxemia accompanying sleep-disordered breathing (SDB) may vary in different populations. Aims of this study were to (1) assess whether severity of SDB is related to uric acid excretion in North American and Southeast European children and (2) evaluate the interaction between nocturnal hypoxemia and country of children's origin in uric acid excretion.
   Methods: Consecutive US and Greek children with snoring who were referred for polysomnography were recruited. Uric acid excretion expressed as uric acid-to-creatinine concentrations ratio in a morning urine specimen was the primary outcome measure.
   Results: One hundred and twenty-six US children (6.8 +/- 0.7 years old) and 123 Greek children (6.4 +/- 2.5 years old) were recruited. Forty-three US and 53 Greek participants had moderate-to-severe nocturnal hypoxemia (SpO(2) nadir <90%). Obstructive apnea-hypopnea index and SpO(2) nadir were related to uric acid excretion in Greek (but not US) children after adjustment by age, gender and body mass index z-score (p < 0.05). There was a significant interaction between severity of hypoxemia and country of children's origin in uric acid excretion after adjustment by age, gender and body mass index z-score (p = 0.036). Greek children with moderate-to-severe hypoxemia had higher uric acid excretion (0.85 +/- 0.35) than those with mild/no hypoxemia (0.69 +/- 0.25) (p = 0.005). US children with moderate-to-severe hypoxemia (0.41 +/- 0.20) did not differ in uric acid excretion from those with mild/no hypoxemia (0.42 +/- 0.22) (p = 0.823).
   Conclusions: Uric acid excretion differs in children with SDB and different ethnic backgrounds or environmental exposures. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Kaditis, Athanasios; Alexopoulos, Emmanouel; Varlami, Vasiliki; Gourgoulianis, Konstantinos] Univ Thessaly, Sch Med, Sleep Disorders Lab, Larisa, Greece.
   [Gozal, David; Snow, Ayelet B.; Kheirandish-Gozal, Leila; Capdevila, Oscar Sans; Bhattacharjee, Rakesh; Kim, Jinkwan] Univ Louisville, Dept Pediat, Div Pediat Sleep Med, Louisville, KY 40292 USA.
   [Gozal, David; Kheirandish-Gozal, Leila] Univ Chicago, Dept Pediat, Chicago, IL 60637 USA.
   [Papathanasiou, Afroditi A.; Zintzaras, Elias] Univ Thessaly, Sch Med, Dept Biomath, Larisa, Greece.
   [Zintzaras, Elias] Tufts Univ, Sch Med, Tufts New England Med Ctr, Inst Clin Res & Hlth Policy Studies, Boston, MA 02111 USA.
C3 University of Thessaly; University of Louisville; University of Chicago;
   University of Thessaly; Tufts University; Tufts Medical Center
RP Kaditis, A (corresponding author), Univ Thessaly, Sch Med, Sleep Disorders Lab, Larisa, Greece.
EM kaditia@hotmail.com
RI Kaditis, Athanasios/H-7208-2019; Bhattacharjee, Rakesh/ABC-8810-2021;
   Kim, Jinyoung/LFS-2554-2024; Gozal, David/ABH-3805-2020
OI ALEXOPOULOS, EMMANOUIL/0000-0001-9578-7915; Gozal,
   Leila/0000-0003-3332-1057; Kim, Jinkwan/0000-0002-7123-1354
FU National Institutes of Health [HL-65270]; University of Thessaly
   Research Committee
FX This study was supported by National Institutes of Health Grant HL-65270
   and by the University of Thessaly Research Committee.
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NR 46
TC 13
Z9 15
U1 0
U2 3
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1389-9457
EI 1878-5506
J9 SLEEP MED
JI Sleep Med.
PD MAY
PY 2010
VL 11
IS 5
BP 489
EP 493
DI 10.1016/j.sleep.2009.06.011
PG 5
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 598ZF
UT WOS:000277878500011
PM 20181522
DA 2025-06-11
ER

PT J
AU Wang, X
   Guo, B
   Yang, XX
   Li, JZ
   Baima, YJ
   Yin, JZ
   Yu, JH
   Xu, H
   Zeng, CM
   Feng, SY
   Wei, J
   Hong, F
   Zhao, X
AF Wang, Xing
   Guo, Bing
   Yang, Xianxian
   Li, Jingzhong
   Baima, Yangji
   Yin, Jianzhong
   Yu, Jianhong
   Xu, Huan
   Zeng, Chunmei
   Feng, Shiyu
   Wei, Jing
   Hong, Feng
   Zhao, Xing
CA China Muti-Ethnic Cohort CMEC Coll
TI Role of Liver Enzymes in the Relationship Between Particulate Matter
   Exposure and Diabetes Risk: A Longitudinal Cohort Study
SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Article
DE particulate matter; liver; diabetes; biomarkers; mediation; mechanisms
ID LONG-TERM EXPOSURE; AIR-POLLUTION; METABOLIC SYNDROME; OXIDATIVE STRESS;
   MEDIATION; MELLITUS; INSULIN; SENSITIVITY; GLUCOSE; ADULTS
AB Context Particulate matter (PM) is an important risk factor for diabetes. However, its underlying mechanisms remain poorly understood. Although liver-derived biological intermediates may play irreplaceable roles in the pathophysiology of diabetes, few studies have explored this in the association between PM and diabetes. Objective We investigated the role of liver enzymes in mediating the relationship between PM exposure and diabetes. Methods We included a total of 7963 participants from the China Multi-Ethnic Cohort. Residential exposure to PM was assessed using a validated spatial-temporal assessment method. Diabetes was diagnosed according to the criteria from American Diabetes Association. Associations between PM, liver enzyme [including alanine aminotransferase (ALT), aspartate aminotransferase, alkaline phosphatase, and gamma-glutamyl transpeptidase (GGT)], and diabetes were estimated using multivariable regression models. The function of liver enzymes in the relationship between PM and diabetes was assessed using mediation analysis. Results PM exposure was positively associated with the odds of diabetes, with odds ratios of 1.32 (95% CI 0.83, 2.09), 1.33 (95% CI 1.07, 1.65), and 1.18 (95% CI 1.02, 1.36) for every 10-mu g/m(3) increment in <= 1 mu m (PM1), <= 2.5 mu m (PM2.5), and <= 10 mu m (PM10) PM, respectively. ALT (4.47%) and GGT (4.78%) exhibited statistically significant mediation effects on the association between PM2.5 and diabetes, and the ALT (4.30%) also had a mediating role on PM10. However, none of the liver enzymes had a significant mediating effect on PM1. Conclusion The relationship between PM and diabetes is partially mediated by liver enzymes, suggesting that lipid accumulation, oxidative stress, and chronic inflammation in the liver may be involved in its pathogenesis.
C1 [Wang, Xing; Guo, Bing; Xu, Huan; Zeng, Chunmei; Feng, Shiyu; Zhao, Xing] Sichuan Univ, West China Sch Publ Hlth, 16,Sect 3,Renmin South Rd, Chengdu 610041, Peoples R China.
   [Wang, Xing; Guo, Bing; Xu, Huan; Zeng, Chunmei; Feng, Shiyu; Zhao, Xing] Sichuan Univ, West China Hosp 4, 16,Sect 3,Renmin South Rd, Chengdu 610041, Peoples R China.
   [Yang, Xianxian] Chongqing Municipal Ctr Dis Control & Prevent, Chongqing, Peoples R China.
   [Li, Jingzhong] Tibet Ctr Dis Control & Prevent, Lhasa, Tibet, Peoples R China.
   [Baima, Yangji] Tibet Univ, Sch Med, Lhasa, Tibet, Peoples R China.
   [Yin, Jianzhong] Kunming Med Univ, Sch Publ Hlth, Kunming, Yunnan, Peoples R China.
   [Yin, Jianzhong] Baoshan Coll Tradit Chinese Med, Baoshan, Peoples R China.
   [Yu, Jianhong] Pidu Dist Ctr Dis Control & Prevent, Chengdu, Sichuan, Peoples R China.
   [Wei, Jing] Univ Maryland, Earth Syst Sci Interdisciplinary Ctr, Dept Atmospher & Ocean Sci, College Pk, MD 20740 USA.
   [Hong, Feng] Guizhou Med Univ, Sch Publ Hlth, Key Lab Environm Pollut Monitoring & Dis Control, Minist Educ, Guiyang 550025, Peoples R China.
C3 Sichuan University; Sichuan University; Tibet University; Kunming
   Medical University; University System of Maryland; University of
   Maryland College Park; Guizhou Medical University; Ministry of Education
   - China
RP Zhao, X (corresponding author), Sichuan Univ, West China Sch Publ Hlth, 16,Sect 3,Renmin South Rd, Chengdu 610041, Peoples R China.; Zhao, X (corresponding author), Sichuan Univ, West China Hosp 4, 16,Sect 3,Renmin South Rd, Chengdu 610041, Peoples R China.; Wei, J (corresponding author), Univ Maryland, Earth Syst Sci Interdisciplinary Ctr, Dept Atmospher & Ocean Sci, College Pk, MD 20740 USA.; Hong, F (corresponding author), Guizhou Med Univ, Sch Publ Hlth, Key Lab Environm Pollut Monitoring & Dis Control, Minist Educ, Guiyang 550025, Peoples R China.
EM xingzhao@scu.edu.cn; weijing_rs@163.com; fhong@gmc.edu.cn;
   zhaoxing731@foxmail.com
RI Zhao, Xing/GLS-7344-2022; Feng, Shiyu/KIH-0789-2024; Wei,
   Jing/L-5459-2017
OI Hong, Feng/0000-0002-6329-5331; Wei, Jing/0000-0002-8803-7056
FU China's National Key Research and Development Program [2017YFC0907305];
   National Natural Science Foundation of China [81973151, 82103943]; China
   Postdoctoral Science Foundation [2020M683335]; Sichuan Provincial
   Science Program Project [2020JDJQ0014]
FX The CMEC baseline survey and repeat survey were supported by China's
   National Key Research and Development Program (grant no.
   2017YFC0907305). This work was also supported by the National Natural
   Science Foundation of China (grant no. 81973151, 82103943), China
   Postdoctoral Science Foundation (grant no. 2020M683335), and the Sichuan
   Provincial Science Program Project (grant no. 2020JDJQ0014). The funders
   had no role in the study design, data collection, data analysis and
   interpretation, writing of the report, or decision to submit the article
   for publication.
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NR 51
TC 9
Z9 10
U1 1
U2 27
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0021-972X
EI 1945-7197
J9 J CLIN ENDOCR METAB
JI J. Clin. Endocrinol. Metab.
PD SEP 28
PY 2022
VL 107
IS 10
BP E4086
EP E4097
DI 10.1210/clinem/dgac438
EA JUL 2022
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 4X4ZI
UT WOS:000836704800001
PM 35861878
OA Bronze
DA 2025-06-11
ER

PT J
AU Arcusa, R
   Carrillo, JA
   Cerdá, B
   Durand, T
   Gil-Izquierdo, A
   Medina, S
   Galano, JM
   Valencia, DV
   Marhuenda, J
   Zafrilla, P
AF Arcusa, Raul
   Angel Carrillo, Juan
   Cerda, Begona
   Durand, Thierry
   Gil-Izquierdo, Angel
   Medina, Sonia
   Galano, Jean-Marie
   Villano Valencia, Debora
   Marhuenda, Javier
   Zafrilla, Pilar
TI Anti-Inflammatory and Antioxidant Capacity of a Fruit and
   Vegetable-Based Nutraceutical Measured by Urinary Oxylipin Concentration
   in a Healthy Population: A Randomized, Double-Blind, Placebo-Controlled
   Clinical Trial
SO ANTIOXIDANTS
LA English
DT Article
DE oxidative stress; metabolic syndrome; inflammation; metabolic diseases;
   isoprostanes; oxylipins
ID OXIDATIVE STRESS; POLYPHENOLS; PROSTAGLANDINS; MARKERS; BIOAVAILABILITY;
   BIOSYNTHESIS; ISOPROSTANES; EICOSANOIDS; CONSUMPTION; VOLUNTEERS
AB Oxylipins, lipid biomarkers of inflammation are considered the gold standard method to evaluate the inflammatory and antioxidant status. The aim of the present study was to investigate whether the administration of a polyphenolic extract shot in the form of a nutraceutical was able to reduce inflammation, measured in urine markers. Ninety-two participants (45 males, 47 females, age 34 +/- 11 years, weight 73.10 +/- 14.29 kg, height 1.72 +/- 9 cm, BMI 24.40 +/- 3.43 kg/m(2)) completed the study after an intervention of two 16-week periods consuming extract or placebo separated by a 4-week washout period. The results showed significant differences in terms of reduction of different pro-inflammatory oxylipins (15-keto-PGF(2 alpha) (from 0.90 +/- 0.25 ng/mL to 0.74 +/- 0.19 ng/mL p < 0.05), ent-PGF(2 alpha) (from 1.59 +/- 0.37 ng/mL to 1.44 +/- 0.32 ng/mL p < 0.05), 2,3-dinor-15-F-2t-Isop) (from 1.17 +/- 0.35 ng/mL to 1.02 +/- 0.27 ng/mL p < 0.05), in total oxylipins count (from 8.03 +/- 1.86 ng/mL to 7.25 +/- 1.23 ng/mL p < 0.05), and increase in PGE(2) (from 1.02 +/- 0.38 ng/mL to 1.26 +/- 0.38 ng/mL p < 0.05) which has an anti-inflammatory character, after extract consumption compared to placebo. The available data seem to indicate that long-term consumption of a nutraceutical with high polyphenol content improves inflammation and oxidation parameters measured in urine, through UHPLC-QqQ-ESI-MS/MS.
C1 [Arcusa, Raul; Angel Carrillo, Juan; Cerda, Begona; Villano Valencia, Debora; Marhuenda, Javier; Zafrilla, Pilar] Univ Catolica San Antonio, Fac Hlth Sci, Murcia 30107, Spain.
   [Durand, Thierry; Galano, Jean-Marie] Univ Montpellier, Ctr Natl Rech Sci, Natl Sch Chem Montpellier,UMR 5247, Inst Biomol Max Mousseron IBMM,Pole Chim Balard R, 1919 Route Mende, F-34293 Montpellier 05, France.
   [Gil-Izquierdo, Angel; Medina, Sonia] CEBAS CSIC, Res Grp Qual Safety & Bioact Plant Foods, Food Sci & Technol Dept, Murcia 30100, Spain.
C3 Universidad Catolica de Murcia; Centre National de la Recherche
   Scientifique (CNRS); Universite de Montpellier; Consejo Superior de
   Investigaciones Cientificas (CSIC); CSIC - Centro de Edafologia y
   Biologia Aplicada del Segura (CEBAS)
RP Marhuenda, J (corresponding author), Univ Catolica San Antonio, Fac Hlth Sci, Murcia 30107, Spain.
EM rarcusa@ucam.edu; jacarrillo4@alu.ucam.edu; bcerda@ucam.edu;
   thierry.durand@umontpellier.fr; angelgil@cebas.csic.es;
   soniamedes@gmail.com; jgalano@univ-montp1.fr; dvillano@ucam.edu;
   jmarhuenda@ucam.edu; mpzafrilla@ucam.edu
RI Cerdá, Begoña/AAC-1788-2022; Zafrilla, Pilar/JAN-5983-2023; Arcusa,
   Raúl/GQP-7591-2022; Medina, Sonia/M-2479-2014; Begona,
   Cerda/K-5993-2014; Gil-Izquierdo, Angel/B-5563-2008; Villano Valencia,
   Debora/F-1022-2012
OI ZAFRILLA, PILAR/0000-0002-1463-7120; Arcusa, Raul/0000-0002-4221-3528;
   Medina, Sonia/0000-0002-7231-6480; Begona, Cerda/0000-0003-0385-1145;
   Gil-Izquierdo, Angel/0000-0001-7646-0386; Villano Valencia,
   Debora/0000-0002-8162-8857
FU Juice Plus Company
FX This study was funded by the Juice Plus Company. At no time has the
   company collaborated in the design or management of the data obtained.
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PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD JUL
PY 2022
VL 11
IS 7
AR 1342
DI 10.3390/antiox11071342
PG 16
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA 3H8BI
UT WOS:000832255500001
PM 35883832
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Duarte, GBS
   Reis, BZ
   Rogero, MM
   Vargas-Mendez, E
   Barbosa, F
   Cercato, C
   Cozzolino, SMF
AF Silva Duarte, Graziela Biude
   Reis, Bruna Zavarize
   Rogero, Marcelo Macedo
   Vargas-Mendez, Ernesto
   Barbosa Junior, Fernando
   Cercato, Cintia
   Franciscato Cozzolino, Silvia Maria
TI Consumption of Brazil nuts with high selenium levels increased
   inflammation biomarkers in obese women: A randomized controlled trial
SO NUTRITION
LA English
DT Article
DE Brazil nut; Selenium; Obesity; Inflammation; Selenoprotein P; Metabolic
   inflammation
ID GENE-EXPRESSION; DOUBLE-BLIND; INSULIN-RESISTANCE; SIGNALING PATHWAYS;
   METABOLIC SYNDROME; OXIDATIVE STRESS; ICP-MS; SUPPLEMENTATION; CELLS;
   HOMEOSTASIS
AB Objective: Increased inflammatory response is an important factor in the pathophysiology of obesity. The mineral selenium (Se), of which one of the main food sources is the Brazil nut, has important antioxidant and anti-inflammatory functions through the action of selenoproteins. Thus, the evaluation of the influence of this micronutrient in this context is of great relevance. The aim of this study was to evaluate the effects of Brazil nut intake with high Se concentrations on inflammatory biomarkers and its relation to Se status in obese women.
   Methods: A randomized controlled clinical trial was carried out with 55 women recruited at Clinical Hospital in Sao Paulo, Brazil. Patients were randomly assigned to either the Brazil nut group (BN) or the control group (CO) and followed up for 2 mo. The BN group consumed 1 unit/d of Brazil nuts (similar to 1261 mu g/Se); the CO group did not receive any intervention. At baseline and after 2 mo, analysis of biochemical parameters related to Se status, oxidative stress, and inflammatory biomarkers were performed.
   Results: At baseline, both groups did not present Se deficiency. In the BN group, a significant increase (P < 0.05) in all Se biomarkers and in gene expression of several proinflammatory parameters (interleukin-6, tumor necrosis factor-a, and Toll-like receptors 2 and 4) were observed after the intervention period. No changes were observed for the CO group.
   Conclusion: Although there were no changes in plasma inflammatory biomarkers levels, a significant increase in gene expression may be an indication of a proinflammatory stimulus in obesity, induced by the consumption of Brazil nuts with high Se levels. (C) 2019 Elsevier Inc. All rights reserved.
C1 [Silva Duarte, Graziela Biude; Reis, Bruna Zavarize; Franciscato Cozzolino, Silvia Maria] Univ Sao Paulo, Fac Pharmaceut Sci, Dept Food & Expt Nutr, Sao Paulo, Brazil.
   [Rogero, Marcelo Macedo] Univ Sao Paulo, Sch Publ Hlth, Dept Nutr, Sao Paulo, Brazil.
   [Rogero, Marcelo Macedo] Sao Paulo Res Fdn, Food Res Ctr FoRC, CEPID FAPESP, Res Innovat & Disseminat Ctr, Sao Paulo, Brazil.
   [Vargas-Mendez, Ernesto] Univ Costa Rica, Sch Med, Dept Biochem, San Jose, Costa Rica.
   [Barbosa Junior, Fernando] Univ Sao Paulo, Fac Pharmaceut Sci Ribeirao Preto, Dept Clin Toxicol & Bromatol Anal, Ribeirao Preto, SP, Brazil.
   [Cercato, Cintia] Univ Sao Paulo, Clin Hosp, Sch Med, Div Endocrinol & Metab, Sao Paulo, Brazil.
C3 Universidade de Sao Paulo; Universidade de Sao Paulo; Fundacao de Amparo
   a Pesquisa do Estado de Sao Paulo (FAPESP); Universidad Costa Rica;
   Universidade de Sao Paulo; Universidade de Sao Paulo
RP Duarte, GBS (corresponding author), Univ Sao Paulo, Fac Pharmaceut Sci, Dept Food & Expt Nutr, Sao Paulo, Brazil.
EM Gbiude@usp.br
RI Rogero, Marcelo/F-6246-2012; Cozzolino, Silvia/K-7623-2016; cercato,
   cintia/O-9163-2017; Duarte, Graziela/Q-7728-2016; Reis, Bruna
   Zavarize/F-3102-2014; Vargas-Mendez, Ernesto/Q-7422-2017; Barbosa Jr,
   Fernando/C-6929-2012
OI Reis, Bruna Zavarize/0000-0001-8726-8699; Cercato,
   Cintia/0000-0002-6181-4951; Macedo Rogero, Marcelo/0000-0003-0517-1645;
   Vargas-Mendez, Ernesto/0000-0002-2555-024X; Barbosa Jr,
   Fernando/0000-0002-2498-0619
FU Sao Paulo Research Foundation (Fundacao de Amparo a Pesquisa do Estado
   de Salo Paulo - FAPESP) [2015/02906-2]; CNPq [142132/2014-4]
FX This work was supported by Sao Paulo Research Foundation (Fundacao de
   Amparo a Pesquisa do Estado de Salo Paulo - FAPESP process:
   2015/02906-2) to SMFC and CNPq (process: 142132/2014-4) to GBSD. The
   funding sources were not involved in study design, collection of
   samples, analysis or interpretation of the data from this study. GBSD,
   MMR, and SMFC designed the study. CC assisted in the recruitment of
   study participants in the Division of Endocrinology and Metabolism from
   the Clinical Hospital. GBSD and BZR conducted the research. FB was
   responsible for the analysis of selenium in plasma and erythrocyte.
   GBSD, BZR, and EVM performed the data analysis and statistics. GBSD and
   MMR wrote the manuscript.
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NR 52
TC 36
Z9 38
U1 1
U2 16
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0899-9007
EI 1873-1244
J9 NUTRITION
JI Nutrition
PD JUL-AUG
PY 2019
VL 63-64
BP 162
EP 168
DI 10.1016/j.nut.2019.02.009
PG 7
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA ID5SC
UT WOS:000471735300025
PM 31026738
DA 2025-06-11
ER

PT S
AU Pasquali, R
   Oriolo, C
AF Pasquali, Renato
   Oriolo, Claudia
BE Pasquali, R
   Pignatelli, D
TI Obesity and Androgens in Women
SO HYPERANDROGENISM IN WOMEN: BEYOND POLYCYSTIC OVARY SYNDROME
SE Frontiers of Hormone Research
LA English
DT Review; Book Chapter
ID POLYCYSTIC-OVARY-SYNDROME; HORMONE-BINDING GLOBULIN; METABOLIC-CLEARANCE
   RATES; WEIGHT-LOSS; POSTMENOPAUSAL WOMEN; BODY-COMPOSITION; OLDER WOMEN;
   PREVALENCE; ENDOCRINE; STRESS
AB Androgen excess is often associated with obesity states, at any age of life, because of changes in the pattern of secretion or metabolism of androgens and in their actions at the level of target tissues, particularly the adipose tissue. Androgen excess plays an important role in favouring the expansion of visceral fat, which characterize so-called visceral obesity. Moreover, there is evidence that the combination of androgen excess and obesity may favour the development of metabolic disorders, such as the metabolic syndrome and type 2 diabetes. In obese adolescent girls, androgen excess may also suggest the potential development of the polycystic ovary syndrome (PCOS). A new hypothesis, based on long-term lifestyle intervention programs or bariatric surgery, supports the concept that a "PCOS secondary to obesity" may exist, as confirmed by the complete resolution of all features defining PCOS after considerable weight loss. Obesity can also develop after long-term exposure to chronic stress, which is characterized by increased activity of the hypothalamic-pituitary-adrenal axis and the sympathetic system combined with higher than normal androgen production rates in women. This increasingly observed condition, often underestimated, should be considered more carefully, not only in mature women but also in girls during adolescence. The presence of a hyperandrogenic state can also be detected in menopausal women, as a consequence of the rearrangement of the sex hormone balance which, in turn, may play some role in determining the development of both visceral adiposity and even obesity and, consequently, metabolic disorders. Undoubtedly, the recognition of the potential negative effects of androgen excess in obese women may open new therapeutic perspectives aimed at achieving a sustained weight loss and its maintenance for as long as possible. (c) 2019 S. Karger AG, Basel
C1 [Pasquali, Renato; Oriolo, Claudia] Univ Alma Mater Studiorum Bologna, Via Santo Stefano 38, IT-40125 Bologna, Italy.
C3 University of Bologna
RP Pasquali, R (corresponding author), Univ Alma Mater Studiorum Bologna, Via Santo Stefano 38, IT-40125 Bologna, Italy.
EM renato.pasquali@unibo.it
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NR 87
TC 52
Z9 56
U1 1
U2 8
PU KARGER
PI BASEL
PA POSTFACH, CH-4009 BASEL, SWITZERLAND
SN 0301-3073
EI 1662-3762
BN 978-3-318-06471-1
J9 FRONT HORM RES
JI Front.Horm.Res.
PY 2019
VL 53
BP 120
EP 134
DI 10.1159/000494908
D2 10.1159/isbn.978-3-318-06471-1
PG 15
WC Endocrinology & Metabolism
WE Book Citation Index – Science (BKCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA BO3ZR
UT WOS:000513765800011
PM 31499497
DA 2025-06-11
ER

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TI Nicotinamide overload may play a role in the development of type 2
   diabetes
SO WORLD JOURNAL OF GASTROENTEROLOGY
LA English
DT Article
DE Type 2 diabetes; Nicotinamide; N-1-methylnicotinamide; Insulin
   resistance; Oxidative stress; Liver; Sweat glands
ID INDUCED INSULIN-RESISTANCE; METABOLIC SYNDROME; UNITED-STATES;
   CLINICAL-IMPLICATIONS; ALDEHYDE OXIDASE; SKELETAL-MUSCLE;
   LIVER-CIRRHOSIS; IN-VITRO; RISK; GLUCOSE
AB AIM: To investigate whether nicotinamide overload plays a role in type 2 diabetes.
   METHODS: Nicotinamide metabolic patterns of 14 diabetic and 14 non-diabetic subjects were compared using HPLC. Cumulative effects of nicotinamide and N-1-methylnicotinamide on glucose metabolism, plasma H2O2 levels and tissue nicotinamide adenine dinucleotide (NAD) contents of adult Sprague-Dawley rats were observed. The role of human sweat glands and rat skin in nicotinamide metabolism was investigated using sauna and burn injury, respectively.
   RESULTS: Diabetic subjects had significantly higher plasma N-1-methylnicotinamide levels 5 h after a 100-mg nicotinamide load than the non-diabetic subjects (0.89 +/- 0.13 mu mol/L vs 0.6 +/- 0.13 mu mol/L, P < 0.001). Cumulative doses of nicotinamide (2 g/kg) significantly increased rat plasma N-1-methylnicotinamide concentrations associated with severe insulin resistance, which was mimicked by N-1-methylnicotinamide. Moreover, cumulative exposure to N-1-methylnicotinamide (2 g/kg) markedly reduced rat muscle and liver NAD contents and erythrocyte NAD/NADH ratio, and increased plasma H2O2 levels. Decrease in NAD/NADH ratio and increase in H2O2 generation were also observed in human erythrocytes after exposure to N-1-methylnicotinamide in vitro. Sweating eliminated excessive nicotinamide (5.3-fold increase in sweat nicotinamide concentration 1 h after a 100-mg nicotinamide load). Skin damage or aldehyde oxidase inhibition with tamoxifen or olanzapine, both being notorious for impairing glucose tolerance, delayed N-1-methylnicotinamide clearance.
   CONCLUSION: These findings suggest that nicotinamide overload, which induced an increase in plasma N-1-methylnicotinamide, associated with oxidative stress and insulin resistance, plays a role in type 2 diabetes. (C) 2009 The WIG Press and Baishideng. All rights reserved.
C1 [Zhou, Shi-Sheng; Li, Da; Sun, Wu-Ping; Lun, Yong-Zhi; Xiao, Fu-Cheng; Jing, Li-Xin; Sun, Shen-Xia; Luo, Ning; Bian, Fu-Ning; Li, Sheng-Fan; Gong, Xiao-Jie; Yu, Zeng-Guo; Sun, Chang-Bin; Zheng, Cong-Long] Dalian Univ Technol, Coll Med, Inst Basic Med Sci, Dalian 116622, Liaoning Prov, Peoples R China.
   [Guo, Ming; Li, Zheng-Ning] Dalian Univ Technol, Coll Environm & Chem Engn, Dalian 116622, Liaoning Prov, Peoples R China.
   [Zhou, Yi-Ming] Natl Inst Nat Sci, Okazaki Inst Integrat Biosci, Okazaki, Aichi 4448787, Japan.
   [Zhang, Li-Bin] Xinxiang Med Coll, Dept Physiol, Xinxiang 453003, Henan Province, Peoples R China.
   [Zou, Wei] Liaoning Normal Univ, Dept Life Sci, Dalian 116029, Liaoning Prov, Peoples R China.
   [Dong, Lai-Bin] PLA 91 Hosp, Dept Neurol, Jiaozuo 454003, Henan Province, Peoples R China.
   [Zhao, Zhi-Gang; Jiang, Dong-Ju] PLA 210 Hosp, Dept Med, Dalian 116021, Liaoning Prov, Peoples R China.
C3 Dalian University of Technology; Dalian University of Technology;
   National Institutes of Natural Sciences (NINS) - Japan; Okazaki
   Institute for Integrative Bioscience (OIIB); Xinxiang Medical
   University; Liaoning Normal University
RP Zhou, SS (corresponding author), Dalian Univ Technol, Coll Med, Inst Basic Med Sci, Dalian 116622, Liaoning Prov, Peoples R China.
EM zhouss@ymail.com
RI Zhou, Yiming/AAK-3059-2021; Sun, Wuping/A-4492-2015; LUN,
   Yong-Zhi/G-2608-2014
OI LUN, Yong-Zhi/0000-0002-7947-9274; Zhou, Shi-Sheng/0000-0001-5156-3610
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NR 46
TC 62
Z9 73
U1 0
U2 17
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 8226 REGENCY DR, PLEASANTON, CA 94588 USA
SN 1007-9327
EI 2219-2840
J9 WORLD J GASTROENTERO
JI World J. Gastroenterol.
PD DEC 7
PY 2009
VL 15
IS 45
BP 5674
EP 5684
DI 10.3748/wjg.15.5674
PG 11
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 529UP
UT WOS:000272544600007
PM 19960564
OA Green Submitted, Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Kitaoka-Higashiguchi, K
   Morikawa, Y
   Miura, K
   Sakurai, M
   Ishizaki, M
   Kido, T
   Naruse, Y
   Nakagawa, H
AF Kitaoka-Higashiguchi, Kazuyo
   Morikawa, Yuko
   Miura, Katsuyuki
   Sakurai, Masaru
   Ishizaki, Masao
   Kido, Teruhiko
   Naruse, Yuchi
   Nakagawa, Hideaki
TI Burnout and Risk Factors for Arteriosclerotic Disease: Follow-up Study
SO JOURNAL OF OCCUPATIONAL HEALTH
LA English
DT Article
DE Arteriosclerotic disease; Burnout; Longitudinal study; Maslach Burnout
   Inventory (MBI); Working population
ID BODY-MASS INDEX; JOB STRAIN; OCCUPATIONAL STRESS; CONSTRUCT-VALIDITY;
   HEALTH BEHAVIORS; ASSOCIATION; OBESITY; MEN; DEMANDS; SUPPORT
AB Burnout and Risk Factors for Arteriosclerotic Disease: Follow-up Study: Kazuyo KITAOKA-HIGASHIGUCHI, et al. Department of Public Health, Kanazawa Medical University-Objectives: The purpose of this longitudinal study was to investigate the effects of burnout on risk factors for arteriosclerotic disease. Methods: Baseline data were collected from 442 male middle managers working for a manufacturing company in Japan. All participants had a physical health check-up and completed the Japanese Maslach Burnout Inventory-General Survey. We calculated the Japanese-specific cut-off points of the MBI-GS and applied "exhaustion +1" criterion to define subjects as healthy or burnout at baseline. Follow-up measures were collected 4-5 yr later for 383 middle managers. Changes in the subjects' waist circumference, body weight, body mass index (BMI), blood pressure, total cholesterol, triglycerides, HDL cholesterol, LDL cholesterol, fasting blood sugar, fasting insulin, HOMAR, and HbA1c over a time period of 4 to 5 yr were compared between the healthy and burnout groups. New cases of large waist circumference, high BMI, metabolic syndrome, hypertension, hypercholesterolemia, high triglycerides, low HDL cholesterol, high LDL cholesterol, and impaired fasting glucose were detected at follow-up. Results: Changes in waist circumference, body weight, and BMI were significantly greater in burned-out managers than in healthy managers. Furthermore, compared to other variables (age and health behaviors such as smoking), burnout was a significant explanatory variable. The odds ratio of the burnout group was 2.80 for hypercholesterolemia with statistical significance after adjusting for age. After adjusting for age, health behaviors, and baseline total cholesterol, the results were similar. Conclusions: Burnout, which results from prolonged exposure to chronic work stress, may be associated with risk factors for arteriosclerotic disease.
C1 [Kitaoka-Higashiguchi, Kazuyo; Morikawa, Yuko; Sakurai, Masaru; Nakagawa, Hideaki] Kanazawa Med Univ, Dept Publ Hlth, Uchinada, Ishikawa 9200293, Japan.
   [Miura, Katsuyuki] Shiga Univ Med Sci, Dept Hlth Sci, Shiga, Japan.
   [Ishizaki, Masao] Kanazawa Med Univ, Dept Social & Environm Med, Uchinada, Ishikawa 9200293, Japan.
   [Kido, Teruhiko] Kanazawa Univ, Sch Hlth Sci, Kanazawa, Ishikawa 9201192, Japan.
   [Naruse, Yuchi] Toyama Univ, Sch Nursing, Toyama, Japan.
C3 Kanazawa Medical University; Shiga University of Medical Science;
   Kanazawa Medical University; Kanazawa University; University of Toyama
RP Kitaoka-Higashiguchi, K (corresponding author), Kanazawa Med Univ, Dept Publ Hlth, Daigaku 1-1, Uchinada, Ishikawa 9200293, Japan.
EM kitaoka@kanazawa-med.ac.jp
RI Sakurai, Masaru/AAC-6551-2021; NISHI, NOBUO/S-6195-2019
OI Kitaoka, Kazuyo/0000-0002-7585-4129; Miura,
   Katsuyuki/0000-0002-2646-9582
FU Scientific Research of Japan [18592433]; Grants-in-Aid for Scientific
   Research [18592433] Funding Source: KAKEN
FX This study was supported by Grants-in-Aid for Scientific Research of
   Japan (Grant No. 18592433).
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NR 52
TC 62
Z9 75
U1 1
U2 16
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1341-9145
EI 1348-9585
J9 J OCCUP HEALTH
JI J. Occup. Health
PD MAR
PY 2009
VL 51
IS 2
BP 123
EP 131
DI 10.1539/joh.L8104
PG 9
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA 432GJ
UT WOS:000265121200003
PM 19212087
OA Green Submitted, Bronze
DA 2025-06-11
ER

PT J
AU Oltman, CL
   Davidson, EP
   Coppey, LJ
   Kleinschmidt, TL
   Lund, DD
   Adebara, ET
   Yorek, MA
AF Oltman, C. L.
   Davidson, E. P.
   Coppey, L. J.
   Kleinschmidt, T. L.
   Lund, D. D.
   Adebara, E. T.
   Yorek, M. A.
TI Vascular and neural dysfunction in Zucker diabetic fatty rats: a
   difficult condition to reverse
SO DIABETES OBESITY & METABOLISM
LA English
DT Article
DE metabolic syndrome; neuropathy; obesity; oxidative stress; reactive
   oxygen species; vascular reactivity
ID ALPHA-LIPOIC ACID; GOTO-KAKIZAKI RATS; OXIDATIVE STRESS; EPINEURIAL
   ARTERIOLES; SUPEROXIDE-PRODUCTION; INSULIN-RESISTANCE; SCIATIC-NERVE;
   NITRIC-OXIDE; BLOOD-FLOW; NEUROPATHY
AB Aim: We had previously demonstrated that vascular and neural dysfunction in Zucker diabetic fatty (ZDF) rats is progressive. In this study, we sought to determine whether monotherapy of ZDF rats can reverse the vascular and nerve defects.
   Methods: ZDF rats at 16 weeks of age were treated for 12 weeks with the angiotensin-converting enzyme inhibitor enalapril, the antioxidant alpha-lipoic acid, the HMG-CoA reductase inhibitor rosuvastatin or the PPAR gamma agonist rosiglitazone. Vasodilation of epineurial arterioles was measured by videomicroscopy. Endoneurial blood flow (EBF) was measured by hydrogen clearance, and nerve conduction velocity was measured following electrical stimulation of motor or sensory nerves.
   Results: Motor nerve conduction velocity (MNCV), sensory nerve conduction velocity (SNCV) (70 and 77% of control, respectively), EBF (64% of control), and vascular relaxation in response to acetylcholine (50% of control) and calcitonin gene-related peptide (CGRP; 73% of control) are impaired in ZDF rats at 28 weeks of age compared with lean littermate controls. Treatment with enalapril and alpha-lipoic acid attenuated the decrease in MNCV and SNCV. Enalapril, alpha-lipoic acid and rosiglitazone treatment of ZDF rats were partially effective in improving endothelium-dependent vascular dysfunction as measured by vascular relaxation in response to acetylcholine. The same drugs also attenuated the decrease in EBF. However, impairment in vascular relaxation in response to CGRP was improved with only alpha-lipoic acid or rosuvastatin treatment. The increase in superoxide and nitrotyrosine levels in vascular tissue was attenuated by all treatments.
   Conclusions: The efficacy of monotherapy treatment of ZDF rats using different classes of drugs for vascular and neural dysfunction once complications have developed did not achieve expected levels. This could be because of the complex aetiology of vascular and neural disease in type 2 diabetes.
C1 [Oltman, C. L.; Davidson, E. P.; Coppey, L. J.; Kleinschmidt, T. L.; Lund, D. D.; Yorek, M. A.] Univ Iowa, Vet Affairs Med Ctr, Iowa City, IA 52242 USA.
   [Oltman, C. L.; Davidson, E. P.; Coppey, L. J.; Lund, D. D.; Adebara, E. T.; Yorek, M. A.] Univ Iowa, Dept Internal Med, Iowa City, IA 52242 USA.
C3 US Department of Veterans Affairs; Veterans Health Administration (VHA);
   Iowa City VA Health Care System; University of Iowa; University of Iowa
RP Yorek, MA (corresponding author), Vet Affairs Med Ctr, Bldg 40, Rm 204, Iowa City, IA 52246 USA.
EM mark-yorek@uiowa.edu
RI Yorek, Mark/AAC-3136-2021
OI Yorek, Mark/0000-0001-7737-5554
FU NIDDK NIH HHS [R56 DK073990, DK073990] Funding Source: Medline
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NR 37
TC 49
Z9 59
U1 0
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1462-8902
EI 1463-1326
J9 DIABETES OBES METAB
JI Diabetes Obes. Metab.
PD JAN
PY 2008
VL 10
IS 1
BP 64
EP 74
DI 10.1111/j.1463-1326.2007.00814.x
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 240JX
UT WOS:000251585000007
PM 17970755
DA 2025-06-11
ER

PT J
AU Coello, K
   Hansen, TH
   Sorensen, N
   Ottesen, NM
   Miskowiak, KW
   Pedersen, O
   Kessing, LV
   Vinberg, M
AF Coello, Klara
   Hansen, Tue Haldor
   Sorensen, Nikolaj
   Ottesen, Ninja Meinhard
   Miskowiak, Kamilla Woznica
   Pedersen, Oluf
   Kessing, Lars Vedel
   Vinberg, Maj
TI Affective disorders impact prevalence of Flavonifractor and
   abundance of Christensenellaceae in gut microbiota
SO PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
LA English
DT Article
DE Affective disorders; Bipolar disorder; Major depressive disorder; High
   risk; Unaffected relatives; Gut microbiota
ID MAJOR DEPRESSIVE DISORDER; BIPOLAR DISORDER; CARDIOVASCULAR-DISEASE;
   SCIENTIFIC STATEMENT; METABOLIC SYNDROME; OXIDATIVE STRESS;
   RATING-SCALE; METAANALYSIS; GENETICS; UNIPOLAR
AB Background Affective disorders (AD) have been associated with a higher prevalence of the gut Flavonifractor genus and a lower abundance of the gut Christensenellaceae family. Objective and methods By pooling two independent study samples of patients with AD (n = 176), their unaffected first-degree relatives (n = 70) and healthy controls (n = 101) we aimed to replicate and extend our prior findings of differential Flavonifractor prevalence and Christensenellaceae abundance when comparing patients with AD and healthy controls. The gut microbiota was profiled using 16S rRNA gene amplicon sequencing. Results The pattern of higher prevalence of Flavonifractor and lower Centered Log-Ratio (CLR) abundance of Christensenellaceae was associated with AD. In generalized linear models the CLR abundance of Christensenellaceae was lower in patients with AD (p = 0.024), and in smokers (p = 1.9*10-4), and inversely associated with increasing waist circumference (p = 0.031). The prevalence of Flavonifractor was higher in patients with AD (p = 0.033) and in smokers (p = 0.036). No impact of psychotropic medication was found. The CLR abundance of Christensenellaceae (p = 0.041), but not the prevalence of Flavonifractor (p = 0.20) could distinguish nonsmoking patients with AD from non-smoking healthy controls, whereas no such associations were found in smokers. Unaffected relatives neither differed from patients with AD nor from healthy controls. Conclusion Compared with findings in healthy controls, AD was associated with a significantly lower CLR abundance of the health-linked Christensenellaceae and a significantly higher prevalence of Flavonifractor; findings that are associated with enhanced oxidative stress and systemic low-grade inflammation. If our observations are validated in future independent studies, they support the notion that parts of aberrant gut microbiota are shared by AD and states of dysmetabolism.
C1 [Coello, Klara; Miskowiak, Kamilla Woznica; Kessing, Lars Vedel; Vinberg, Maj] Copenhagen Univ Hosp, Rigshosp, Copenhagen Affect Disorders Res Ctr CADIC, Psychiat Ctr Copenhagen, Copenhagen, Denmark.
   [Hansen, Tue Haldor; Pedersen, Oluf] Ctr Basic Metab Res, Novo Nordisk Fdn, Sect Metab Genet, Copenhagen, Denmark.
   [Hansen, Tue Haldor] Univ Copenhagen, Fac Hlth & Med Sci, Copenhagen, Denmark.
   [Sorensen, Nikolaj] Clin Microbi, Copenhagen, Denmark.
   [Ottesen, Ninja Meinhard; Pedersen, Oluf; Kessing, Lars Vedel; Vinberg, Maj] Copenhagen Univ Hosp Bispebjerg, Child & Adolescent Mental Hlth Ctr, Copenhagen, Denmark.
   [Vinberg, Maj] Copenhagen Univ Hosp, Psychiat Ctr North Zealand, Psychiat Res Unit, Hillerod, Denmark.
C3 University of Copenhagen; Copenhagen University Hospital;
   Rigshospitalet; Novo Nordisk Foundation; University of Copenhagen;
   University of Copenhagen; Bispebjerg Hospital; Copenhagen University
   Hospital; University of Copenhagen; Copenhagen University Hospital
RP Coello, K (corresponding author), Rigshosp, Psychiat Ctr Copenhagen, Dept O, Blegdamsvej 9, DK-2100 Copenhagen, Denmark.
EM klara.coello@regionh.dk
RI Pedersen, Oluf/Z-1731-2019; Vinberg/ABC-7493-2021; Kessing,
   Lars/JNS-2493-2023; Coello, Klara/AAZ-6545-2020; Hansen, Tue/S-7724-2016
OI Hansen, Tue/0000-0001-5948-8993; Kessing, Lars/0000-0001-9377-9436;
   Miskowiak, Kamilla/0000-0003-2572-1384
FU Mental Health Services; Capital Region of Denmark [164019]; Capital
   Region of Denmark; Augustinus Foundation; Danish Council for Independent
   Research, Medical Sciences [DFF418300570]; A.P. MOller Foundation for
   the Advancement of Medical Science [1555]; BeckettFonden [48282]; Novo
   Nordisk Foundation
FX This study was supported by grants from the Mental Health Services,
   Capital Region of Denmark (PhD student 164019 and the BIO study) , The
   Capital Region of Denmark, the Augustinus Foundation, The Danish Council
   for Independent Research, Medical Sciences (DFF418300570) , the A.P.
   MOller Foundation for the Advancement of Medical Science (1555) , and
   BeckettFonden (48282) . The Novo Nordisk Foundation Center for Basic
   Metabolic Research is an independent research centre at the University
   of Copenhagen partially funded by an unrestricted donation from the Novo
   Nordisk Foundation.
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NR 52
TC 28
Z9 29
U1 1
U2 19
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0278-5846
EI 1878-4216
J9 PROG NEURO-PSYCHOPH
JI Prog. Neuro-Psychopharmacol. Biol. Psychiatry
PD AUG 30
PY 2021
VL 110
AR 110300
DI 10.1016/j.pnpbp.2021.110300
EA MAR 2021
PG 9
WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA TG0DE
UT WOS:000671082800029
PM 33713734
DA 2025-06-11
ER

PT J
AU Balakumar, P
   Sambathkumar, R
   Mahadevan, N
   Bin Muhsinah, A
   Alsayari, A
   Venkateswaramurthy, N
   Dhanaraj, SA
AF Balakumar, Pitchai
   Sambathkumar, Ramanathan
   Mahadevan, Nanjaian
   Bin Muhsinah, Abdullatif
   Alsayari, Abdulrhman
   Venkateswaramurthy, Nallasamy
   Dhanaraj, Sokkalingam A.
TI Molecular targets of fenofibrate in the cardiovascular-renal axis: A
   unifying perspective of its pleiotropic benefits
SO PHARMACOLOGICAL RESEARCH
LA English
DT Review
DE Fenofibrate; PPAR alpha agonist; Dyslipidemia; Pleiotropic actions;
   Cellular signals; Cardiovascular-renal protection
ID VASCULAR ENDOTHELIAL FUNCTION; ACTIVATED RECEPTOR-ALPHA;
   FATTY-ACID-METABOLISM; PPAR-ALPHA; AGONIST FENOFIBRATE;
   CARDIAC-HYPERTROPHY; OXIDATIVE STRESS; RAT-HEART; TGF-BETA;
   SIRT1-MEDIATED DEACETYLATION
AB The activation of peroxisome proliferator-activated receptor alpha (PPAR alpha) is a key pharmacological drug target for dyslipidemic management. Dyslipidemia is associated with abnormal serum lipid profiles viz. elevated total cholesterol, high triglyceride, elevated low-density lipoprotein cholesterol, and reduced high-density lipoprotein cholesterol levels. Fenofibrate, a third-generation fibric acid derivative, is an activator of PPAR alpha indicated for the treatment of mixed dyslipidemia and hypertriglyceridemia in adults. Fenofibrate is considered an important lipid-lowering medication employed in patients afflicted with atherogenic dyslipidemia. Intriguingly, recent bench studies have demonstrated an array of cardiovascular and renal pleiotropic beneficial activities of fenofibrate, besides its foremost lipid-lowering action. The activation of PPAR alpha by fenofibrate could negatively regulate the cardiomyocyte hypertrophy. In addition, fenofibrate has been suggested to have a protective effect against experimental ischemia/reperfusion injury in the myocardium in part via endoplasmic reticulum stress inhibition. Fenofibrate has also been shown to suppress arrhythmias in isolated rat hearts subjected to ischemic/reperfusion-induced cardiac injury. Moreover, in a rat model of metabolic syndrome and myocardial ischemia, fenofibrate therapy has been shown to restore antioxidant protection and improve myocardial insulin resistance. Furthermore, studies have highlighted the pleiotropic vascular endothelial protective and antihypertensive actions of fenofibrate. Interestingly, recent bench studies have demonstrated renoprotective actions of fenofibrate by implicating diverse mechanisms. This review sheds light on the current perspectives and molecular mechanistic aspects pertaining to the cardiovascular pleiotropic actions of fenofibrate. Additionally, the renal pleiotropic actions of fenofibrate by focusing its possible modulatory role on renal fibrosis, inflammation and renal epithelial-to-mesenchymal transition have been enlightened.
C1 [Balakumar, Pitchai; Sambathkumar, Ramanathan; Venkateswaramurthy, Nallasamy] JKK Nattraja Coll Pharm, Kumarapalayam 638183, Tamil Nadu, India.
   [Mahadevan, Nanjaian; Bin Muhsinah, Abdullatif; Alsayari, Abdulrhman] King Khalid Univ, Coll Pharm, Abha 62529, Saudi Arabia.
   [Dhanaraj, Sokkalingam A.] Deemed Be Univ, Periyar Maniammai Inst Sci & Technol, Vallam 613403, India.
C3 King Khalid University; Periyar Maniammai Institute of Science &
   Technology
RP Balakumar, P (corresponding author), JKK Nattraja Coll Pharm, Kumarapalayam 638183, Tamil Nadu, India.
EM pbala2006@gmail.com
RI Balakumar, Pitchai/IVV-0100-2023; Bin Muhsinah,
   Abdullatif/AAN-4078-2021; Alsayari, Abdulrhman/AEI-5615-2022; Nallasamy,
   Venkateswaramurthy/GPG-0806-2022
OI Ramanathan, Dr Sambathkumar/0000-0003-1454-9582; Nallasamy,
   Venkateswaramurthy/0000-0002-8623-7898
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NR 95
TC 23
Z9 24
U1 1
U2 12
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 1043-6618
J9 PHARMACOL RES
JI Pharmacol. Res.
PD JUN
PY 2019
VL 144
BP 132
EP 141
DI 10.1016/j.phrs.2019.03.025
PG 10
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA IH2MK
UT WOS:000474328700011
PM 30970278
DA 2025-06-11
ER

PT J
AU Kim, DH
   Puri, N
   Sodhi, K
   Falck, JR
   Abraham, NG
   Shapiro, J
   Schwartzman, ML
AF Kim, Dong Hyun
   Puri, Nitin
   Sodhi, Komal
   Falck, John R.
   Abraham, Nader G.
   Shapiro, Joseph
   Schwartzman, Michal L.
TI Cyclooxygenase-2 dependent metabolism of 20-HETE increases adiposity and
   adipocyte enlargement in mesenchymal stem cell-derived adipocytes
SO JOURNAL OF LIPID RESEARCH
LA English
DT Article
DE adipogenesis; arachidonic acid; mesenchymal stem cells
ID HIGH-FAT DIET; 20-HYDROXYEICOSATETRAENOIC ACID SYNTHESIS;
   SMOOTH-MUSCLE-CELLS; OXIDATIVE STRESS; ENDOTHELIAL DYSFUNCTION;
   ARACHIDONIC-ACID; CYTOCHROME-P450 METABOLITES; INFLAMMATORY CYTOKINES;
   VASCULAR DYSFUNCTION; CIRCULATING INSULIN
AB 20-Hydroxy-5,8,11,14-eicosatetraenoic acid (20-HETE), a product of the cytochrome P450 (CYP)-catalyzed omega-hydroxylation of arachidonic acid, induces oxidative stress and, in clinical studies, is associated with increased body mass index (BMI) and the metabolic syndrome. This study was designed to examine the effects of exogenous 20-HETE on mesenchymal stem cell (MSC)-derived adipocytes. The expression levels of CYP4A11 and CYP4F2 (major 20-HETE synthases in humans) in MSCs decreased during adipocyte differentiation; however, exogenous administration of 20-HETE (0.1-1 mu M) increased adipogenesis in a dose-dependent manner in these cells (P < 0.05). The inability of a 20-HETE analog to reproduce these effects suggested the involvement of a metabolic product of 20-HETE in mediating its pro-adipogenic effects. A cyclooxygenase (COX)-1 selective inhibitor enhanced, whereas a COX-2 selective or a dual COX-1/2 inhibitor attenuated adipogenesis induced by 20-HETE. The COX-derived metabolite of 20-HETE, 20-OH-PGE(2), enhanced adipogenesis and lipid accumulation in MSCs. The pro-adipogenic effects of 20-HETE and 20-OH-PGE(2) resulted in the increased expression of the adipogenic regulators PPAR gamma and beta-catenin in MSC-derived adipocytes. Taken together we show for the first time that 20-HETE-derived COX-2-dependent 20-OH-PGE(2) enhances mature inflamed adipocyte hypertrophy in MSC undergoing adipogenic differentiation.-Kim, D. H., N. Puri, K. Sodhi, J. R. Falck, N. G. Abraham, J. Shapiro, and M. L. Schwartzman. Cyclooxygenase-2 dependent metabolism of 20-HETE increases adiposity and adipocyte enlargement in mesenchymal stem cell-derived adipocytes. J. Lipid Res. 2013. 54: 786-793.
C1 [Kim, Dong Hyun; Sodhi, Komal; Abraham, Nader G.; Shapiro, Joseph] Marshall Univ, Joan C Edwards Sch Med, Huntington, WV 25755 USA.
   [Puri, Nitin] Univ Toledo, Coll Med, Dept Physiol & Pharmacol, Toledo, OH 43606 USA.
   [Falck, John R.] Univ Texas SW Med Ctr Dallas, Dept Biochem & Pharmacol, Dallas, TX 75390 USA.
   [Schwartzman, Michal L.] New York Med Coll, Dept Pharmacol, Valhalla, NY 10595 USA.
C3 Marshall University; University System of Ohio; University of Toledo;
   University of Texas System; University of Texas Southwestern Medical
   Center Dallas; New York Medical College
RP Abraham, NG (corresponding author), Marshall Univ, Joan C Edwards Sch Med, Huntington, WV 25755 USA.
EM abrahamn@marshall.edu
RI Falck, John/B-3030-2011; Kim, Dong/W-5846-2019
OI Falck, John/0000-0002-9219-7845
FU National Institutes of Health [HL-34300, HL-55601]; BrickStreet
   Foundation
FX This work was supported by National Institutes of Health Grants HL-34300
   (M. L. S.) and HL-55601 (N.G.A.), and by the BrickStreet Foundation
   (J.S., N.G.A.). Its contents are solely the responsibility of the
   authors and do not necessarily represent the official views of the
   National Institutes of Health.
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NR 47
TC 46
Z9 51
U1 1
U2 10
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0022-2275
EI 1539-7262
J9 J LIPID RES
JI J. Lipid Res.
PD MAR
PY 2013
VL 54
IS 3
BP 786
EP 793
DI 10.1194/jlr.M033894
PG 8
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 088ZM
UT WOS:000314877000021
PM 23293373
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Higaki, Y
   Mikami, T
   Fujii, N
   Hirshman, MF
   Koyama, K
   Seino, T
   Tanaka, K
   Goodyear, LJ
AF Higaki, Yasuki
   Mikami, Toshio
   Fujii, Nobuharu
   Hirshman, Michael F.
   Koyama, Katsuhiro
   Seino, Tetsuya
   Tanaka, Keitaro
   Goodyear, Laurie J.
TI Oxidative stress stimulates skeletal muscle glucose uptake through a
   phosphatidylinositol 3-kinase-dependent pathway
SO AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
LA English
DT Article
DE hydrogen peroxide; Akt phosphorylation; adenosine
   monophosphate-activated protein kinase
ID ACTIVATED PROTEIN-KINASE; TYROSINE-PHOSPHATASE 1B; INSULIN-RESISTANCE;
   HYDROGEN-PEROXIDE; SIGNALING PATHWAYS; NITRIC-OXIDE; GLUT4
   TRANSLOCATION; METABOLIC SYNDROME; 3T3-L1 ADIPOCYTES; XANTHINE-OXIDASE
AB We determined the acute effects of oxidative stress on glucose uptake and intracellular signaling in skeletal muscle by incubating muscles with reactive oxygen species (ROS). Xanthine oxidase (XO) is a superoxide-generating enzyme that increases ROS. Exposure of isolated rat extensor digitorum longus (EDL) muscles to Hx/XO (Hx/XO) for 20 min resulted in a dose-dependent increase in glucose uptake. To determine whether the mechanism leading to Hx/XO-stimulated glucose uptake is associated with the production of H2O2, EDL muscles from rats were preincubated with the H2O2 scavenger catalase or the superoxide scavenger superoxide dismutase (SOD) prior to incubation with Hx/XO. Catalase treatment, but not SOD, completely inhibited the increase in Hx/XO-stimulated 2-deoxyglucose(2-DG) uptake, suggesting that H2O2 is an intermediary leading to Hx/XO-stimulated glucose uptake with incubation. Direct H2O2 also resulted in a dose-dependent increase in 2-DG uptake in isolated EDL muscles, and the maximal increase was threefold over basal levels at a concentration of 600 mu mol/l H2O2. H2O2- stimulated 2-DG uptake was completely inhibited by the phosphatidylinositol 3-kinase(PI3K) inhibitor wortmannin, but not the nitric oxide inhibitor N-G-monomethyl-L-arginine. H2O2 stimulated the phosphorylation of Akt Ser(473) (7-fold) and Thr(308) (2-fold) in isolated EDL muscles. H2O2 at 600 mu mol/l had no effect on ATP concentrations and did not increase the activities of either the alpha 1 or alpha 2 catalytic isoforms of AMP-activated protein kinase. These results demonstrate that acute exposure of muscle to ROS is a potent stimulator of skeletal muscle glucose uptake and that this occurs through a PI3K-dependent mechanism.
C1 [Higaki, Yasuki; Tanaka, Keitaro] Saga Univ, Fac Med, Dept Prevent Med, Saga 8498501, Japan.
   [Mikami, Toshio] Nippon Med Coll, Dept Hlth & Sport Sci, Kanagawa, Japan.
   [Fujii, Nobuharu; Hirshman, Michael F.; Goodyear, Laurie J.] Harvard Univ, Sch Med, Boston, MA USA.
   [Fujii, Nobuharu; Hirshman, Michael F.] Brigham & Womens Hosp, Dept Med, Div Res, Joslin Diabet Ctr, Boston, MA 02115 USA.
   [Koyama, Katsuhiro] Univ Yamanashi, Fac Educ & Human Sci, Yamanashi, Japan.
   [Seino, Tetsuya] Kisarazu Natl Coll Technol, Liberal Arts Div, Chiba, Japan.
C3 Saga University; Nippon Medical School; Harvard University; Harvard
   Medical School; Harvard University; Harvard University Medical
   Affiliates; Brigham & Women's Hospital; Joslin Diabetes Center, Inc.;
   University of Yamanashi
RP Higaki, Y (corresponding author), Saga Univ, Fac Med, Dept Prevent Med, Saga 8498501, Japan.
EM higaki@cc.saga-u.ac.jp
RI Fujii, Nobuharu/J-2724-2014; Koyama, Katsuhiro/AFQ-6600-2022
FU NIAMS NIH HHS [AR-45670, AR-42238, R01 AR045670, R01 AR042238] Funding
   Source: Medline
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NR 57
TC 105
Z9 121
U1 0
U2 5
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0193-1849
J9 AM J PHYSIOL-ENDOC M
JI Am. J. Physiol.-Endocrinol. Metab.
PD MAY
PY 2008
VL 294
IS 5
BP E889
EP E897
DI 10.1152/ajpendo.00150.2007
PG 9
WC Endocrinology & Metabolism; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Physiology
GA 295VI
UT WOS:000255501600012
PM 18303121
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Lim, L
AF Lim, Lew
TI Modifying Alzheimer's disease pathophysiology with photobiomodulation:
   model, evidence, and future with EEG-guided intervention
SO FRONTIERS IN NEUROLOGY
LA English
DT Review
DE photobiomodulation; Alzheimer's disease; pathophysiology; clinical
   evidence; clinical studies; EEG; artificial intelligence; default mode
   network
ID TRAUMATIC BRAIN-INJURY; LEVEL LASER THERAPY; NEAR-INFRARED LIGHT;
   CYTOCHROME-C-OXIDASE; CEREBRAL-BLOOD-FLOW; AMYLOID-BETA; NEUROTROPHIC
   FACTORS; MEMORY IMPAIRMENT; OXIDATIVE STRESS; MECHANISMS
AB This manuscript outlines a model of Alzheimer's Disease (AD) pathophysiology in progressive layers, from its genesis to the development of biomarkers and then to symptom expression. Genetic predispositions are the major factor that leads to mitochondrial dysfunction and subsequent amyloid and tau protein accumulation, which have been identified as hallmarks of AD. Extending beyond these accumulations, we explore a broader spectrum of pathophysiological aspects, including the blood-brain barrier, blood flow, vascular health, gut-brain microbiodata, glymphatic flow, metabolic syndrome, energy deficit, oxidative stress, calcium overload, inflammation, neuronal and synaptic loss, brain matter atrophy, and reduced growth factors. Photobiomodulation (PBM), which delivers near-infrared light to selected brain regions using portable devices, is introduced as a therapeutic approach. PBM has the potential to address each of these pathophysiological aspects, with data provided by various studies. They provide mechanistic support for largely small published clinical studies that demonstrate improvements in memory and cognition. They inform of PBM's potential to treat AD pending validation by large randomized controlled studies. The presentation of brain network and waveform changes on electroencephalography (EEG) provide the opportunity to use these data as a guide for the application of various PBM parameters to improve outcomes. These parameters include wavelength, power density, treatment duration, LED positioning, and pulse frequency. Pulsing at specific frequencies has been found to influence the expression of waveforms and modifications of brain networks. The expression stems from the modulation of cellular and protein structures as revealed in recent studies. These findings provide an EEG-based guide for the use of artificial intelligence to personalize AD treatment through EEG data feedback.
C1 [Lim, Lew] Vielight Inc, Toronto, ON, Canada.
RP Lim, L (corresponding author), Vielight Inc, Toronto, ON, Canada.
EM lewlim@vielight.com
FX The author(s) declare that no financial support was received for the
   research, authorship, and/or publication of this article.
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NR 246
TC 3
Z9 4
U1 6
U2 15
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2295
J9 FRONT NEUROL
JI Front. Neurol.
PD AUG 23
PY 2024
VL 15
AR 1407785
DI 10.3389/fneur.2024.1407785
PG 26
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA E9H4Y
UT WOS:001306037500001
PM 39246604
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Xu, MR
   Jin, CH
   Lu, JX
   Li, MF
   Li, LX
AF Xu, Man-Rong
   Jin, Chun-Hua
   Lu, Jun-Xi
   Li, Mei-Fang
   Li, Lian-Xi
TI High-normal unconjugated bilirubin is associated with decreased risk of
   chronic kidney disease in type 2 diabetes: A real-world study
SO DIABETES-METABOLISM RESEARCH AND REVIEWS
LA English
DT Article
DE bilirubin; chronic kidney disease; inflammation; oxidative stress; type
   2 diabetes; unconjugated bilirubin
ID URIC-ACID EXCRETION; SERUM BILIRUBIN; OXIDATIVE STRESS; METABOLIC
   SYNDROME; INFLAMMATION; ALBUMINURIA; PROGRESSION; PREVALENCE;
   ATHEROSCLEROSIS; COMPLICATIONS
AB Objective To investigate the association between serum unconjugated bilirubin (UCB) within normal limits and chronic kidney disease (CKD) in T2DM patients.Method This cross-sectional, real-world study was performed in 8661 hospitalised T2DM patients. The subjects were stratified into quintiles based on serum UCB levels. The clinical characteristics and CKD prevalence were compared among the UCB quantile groups. The associations of serum UCB levels and quintiles with CKD were also analysed by binary logistic regression.Results After controlling for age, sex, and diabetes duration (DD), the CKD prevalence (20.4%, 12.2%, 10.6%, 8.3%, and 6.4% for the first, second, third, fourth, and fifth quintiles, respectively, p < 0.001 for trend) was significantly decreased across the serum UCB quintiles. The fully adjusted regression model showed negative associations of serum UCB levels (OR: 0.660, 95% CI: 0.585-0.744; p < 0.001 for trend) and quintiles (p < 0.001) with the presence of CKD. Compared with the subjects in the lowest UCB quintile, the risk of CKD decreased by 36.2%, 54.3%, 53.8%, and 62.1%, respectively, in those from the second to the highest UCB quintile. Additionally, C-reactive protein (CRP) levels were significantly higher in the subjects with CKD than in those without CKD (p < 0.001), and significantly decreased across the UCB quintiles (p < 0.001 for trend).Conclusions Serum UCB levels within the normal range were significantly and negatively linked to CKD in T2DM patients. High-normal UCB may be an independent protective factor for CKD by its antioxidant and the following anti-inflammatory activities through its signalling activity, which was indicated by clearly decreased CRP levels across the UCB quintiles.
C1 [Xu, Man-Rong; Lu, Jun-Xi; Li, Lian-Xi] Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 6, Shanghai Diabet Inst, Shanghai Clin Ctr Diabet,Sch Med,Dept Endocrinol &, Shanghai, Peoples R China.
   [Jin, Chun-Hua] Shanghai Jiao Tong Univ, Shanghai Songjiang Dist Cent Hosp, Songjiang Hosp, Sch Med Preparatory Stage,Dept Endocrinol & Metab, Shanghai, Peoples R China.
   [Li, Mei-Fang] Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 6, Sch Med, Dept Emergency, Shanghai, Peoples R China.
C3 Shanghai Jiao Tong University; Shanghai Jiao Tong University; Shanghai
   Jiao Tong University
RP Li, LX (corresponding author), Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 6, Shanghai Diabet Inst, Shanghai Clin Ctr Diabet,Sch Med,Dept Endocrinol &, Shanghai, Peoples R China.; Li, MF (corresponding author), Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 6, Sch Med, Dept Emergency, Shanghai, Peoples R China.
EM li_meifang1@126.com; lilx@sjtu.edu.cn
RI Xu, Man-Rong/JSK-5944-2023
OI Xu, Manrong/0000-0002-0519-1593; Li, Lian-Xi/0000-0001-6073-4901
FU National Natural Science Foundation of China [81170759, 81770813,
   82070866]; National Key Research and Development Plan [2018YFC1314900,
   2018YFC1314905]; Translational Medicine National Key Science and
   Technology Infrastructure Open Project [TMSK-2021-116]; Shanghai
   Research Center for Endocrine and Metabolic Diseases [2022ZZ01002];
   Exploratory Clinical Research Project of Shanghai Sixth People's
   Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
   [ynts202105]; Shanghai Municipal Key Clinical Specialty
FX <STRONG> </STRONG>National Natural Science Foundation of China,
   Grant/Award Numbers: 81170759, 81770813, 82070866; National Key Research
   and Development Plan, Grant/Award Numbers: 2018YFC1314900,
   2018YFC1314905; Translational Medicine National Key Science and
   Technology Infrastructure Open Project, Grant/Award Number:
   TMSK-2021-116; Shanghai Research Center for Endocrine and Metabolic
   Diseases, Grant/Award Number: 2022ZZ01002; Exploratory Clinical Research
   Project of Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao
   Tong University School of Medicine, Grant/Award Number: ynts202105;
   Shanghai Municipal Key Clinical Specialty
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NR 75
TC 4
Z9 4
U1 0
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1520-7552
EI 1520-7560
J9 DIABETES-METAB RES
JI Diabetes-Metab. Res. Rev.
PD SEP
PY 2023
VL 39
IS 6
DI 10.1002/dmrr.3672
EA JUN 2023
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA R0WO2
UT WOS:001007515000001
PM 37309279
DA 2025-06-11
ER

PT J
AU Yang, J
   Zheng, YT
   Li, C
   Gao, J
   Meng, XB
   Zhang, K
   Wang, WY
   Shao, CL
   Tang, YD
AF Yang, Jie
   Zheng, Yitian
   Li, Chen
   Gao, Jun
   Meng, Xiangbin
   Zhang, Kuo
   Wang, Wenyao
   Shao, Chunli
   Tang, Yi-Da
TI The Impact of the Stress Hyperglycemia Ratio on Short-term and Long-term
   Poor Prognosis in Patients With Acute Coronary Syndrome: Insight From a
   Large Cohort Study in Asia
SO DIABETES CARE
LA English
DT Article
ID CHRONIC GLYCEMIC RATIO; IN-HOSPITAL OUTCOMES; CARDIOVASCULAR-DISEASE;
   METABOLIC SYNDROME; MYOCARDIAL-INFARCTION; RELATIVE HYPERGLYCEMIA;
   SEVERE HYPOGLYCEMIA; INSULIN-RESISTANCE; VASCULAR EVENTS; ARTERY-DISEASE
AB OBJECTIVEIn recent years, some studies have indicated that a novel marker described as the stress hyperglycemia ratio (SHR) can reflect true acute hyperglycemic status and is associated with the short-term poor prognosis in patients with acute myocardial infarction. In the current study we evaluated the association of SHR with adverse cardiovascular events among patients with acute coronary syndrome (ACS). RESEARCH DESIGN AND METHODSWe consecutively enrolled 5,562 ACS patients who underwent drug-eluting stent (DES) implantation. All subjects were divided into five groups according to SHR, which was determined by the following formula: ABG / [(28.7 x HbA(1c) %) - 46.7], where ABG is admission blood glucose level. The primary end point was major adverse cardiovascular and cerebrovascular events (MACCE) at the 2-year follow-up, and the secondary end point included major adverse cardiovascular events (MACE) at 2-year follow-up, cardiac death, and nonfatal myocardial infarction (MI) at 2-year follow-up and in-hospital cardiac death and nonfatal MI. RESULTSA total of 643 MACCE were recorded during a median follow-up of 28.3 months. Kaplan-Meier survival analysis showed the lowest MACCE incidence in quintile 3 (P < 0.001). Moreover, the outcomes of restricted cubic spline analysis suggested that there was a U-shaped or J-shaped association between the SHR and early and late cardiovascular outcomes even after adjustment for other confounding factors. CONCLUSIONSThere were U-shaped associations of SHR with MACCE rate and MACE rate at 2-year follow-ups and J-shaped associations of SHR with in-hospital cardiac death and MI and that at 2-year follow-up in ACS patients who underwent DES implantation, and the inflection point of SHR for poor prognosis was 0.78.
C1 [Yang, Jie; Zheng, Yitian; Li, Chen; Zhang, Kuo; Wang, Wenyao] Chinese Acad Med Sci & Peking Union Med Coll, Fuwai Hosp, State Key Lab Cardiovasc Dis, Natl Ctr Cardiovasc Dis,Dept Cardiol, Beijing, Peoples R China.
   [Gao, Jun; Meng, Xiangbin; Shao, Chunli; Tang, Yi-Da] Peking Univ Third Hosp, Dept Cardiol, Minist Educ, Beijing, Peoples R China.
   [Gao, Jun; Meng, Xiangbin; Shao, Chunli; Tang, Yi-Da] Peking Univ Third Hosp, Inst Vasc Med, Minist Educ, Beijing, Peoples R China.
   [Gao, Jun; Meng, Xiangbin; Shao, Chunli; Tang, Yi-Da] Minist Educ, Key Lab Mol Cardiovasc Sci, Beijing, Peoples R China.
C3 Chinese Academy of Medical Sciences - Peking Union Medical College;
   Peking Union Medical College; Fu Wai Hospital - CAMS; Ministry of
   Education - China; Ministry of Education - China; Ministry of Education
   - China
RP Shao, CL; Tang, YD (corresponding author), Peking Univ Third Hosp, Dept Cardiol, Minist Educ, Beijing, Peoples R China.; Shao, CL; Tang, YD (corresponding author), Peking Univ Third Hosp, Inst Vasc Med, Minist Educ, Beijing, Peoples R China.; Shao, CL; Tang, YD (corresponding author), Minist Educ, Key Lab Mol Cardiovasc Sci, Beijing, Peoples R China.
EM drtangyida@126.com; chunlishao@126.com
RI Yang, Jie/AAE-4355-2022; Meng, Xiangbin/GLT-5365-2022
FU National Key R&D Program of China; National Natural Science Foundation
   of China; Beijing Nova Program; Beijing Municipal Science & Technology
   Commission;  [2020YFC2004700];  [81825003];  [91957123];  [81800327]; 
   [81900272];  [Z201100006820002]
FX Article Information Acknowledgments. The authors thank all the
   investigators and subjects who participated in this project. Funding.
   This work was supported by National Key R&D Program of China grant
   2020YFC2004700; National Natural Science Foundation of China grants
   81825003, 91957123, 81800327, and 81900272; and Beijing Nova Program
   grant Z201100006820002 from Beijing Municipal Science & Technology
   Commission. Duality of Interest. No potential conflicts of interest
   relevant to this article were reported. Author Contributions. J.Y.,
   C.S., and Y.-D.T. participated in the study design. Y.Z., C.L., J.G.,
   and X.M. participated in data collection. J.Y., K.Z., and W.W. performed
   the statistical analysis. J.Y. drafted the manuscript. All authors read
   and approved the final manuscript. Y.-D.T. is the guarantor of this work
   and, as such, had full access to all the data in the study and takes
   responsibility for the integrity of the data and the accuracy of the
   data analysis.
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TC 117
Z9 118
U1 3
U2 16
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0149-5992
EI 1935-5548
J9 DIABETES CARE
JI Diabetes Care
PD APR
PY 2022
VL 45
IS 4
BP 947
EP 956
DI 10.2337/dc21-1526
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 5U4AI
UT WOS:000876491300029
PM 35045167
OA Green Submitted
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Busnelli, A
   Lattuada, D
   Ferrari, S
   Reschini, M
   Colciaghi, B
   Somigliana, E
   Fedele, L
   Ferrazzi, E
AF Busnelli, Andrea
   Lattuada, Debora
   Ferrari, Stefania
   Reschini, Marco
   Colciaghi, Barbara
   Somigliana, Edgardo
   Fedele, Luigi
   Ferrazzi, Enrico
TI Mitochondrial DNA Copy Number in Peripheral Blood in the First Trimester
   of Pregnancy and Different Preeclampsia Clinical Phenotypes Development:
   A Pilot Study
SO REPRODUCTIVE SCIENCES
LA English
DT Article
DE mitochondria; mitochondrial DNA; preeclampsia; pregnancy; prediction
ID INTRAUTERINE GROWTH RESTRICTION; METABOLIC SYNDROME; RECEPTOR-GAMMA;
   QUANTIFICATION; ASSOCIATIONS; SENSE; RISK
AB Inflammation and oxidative stress are intrinsically linked to early poor placentation, typical of pregnancies complicated by preeclampsia associated with intrauterine growth restriction (PE-IUGR). Low mitochondrial DNA copy number (mtDNAcn) in peripheral blood constitutes a good peripheral surrogate marker of inflammation and oxidative stress. On these basis, we explored a possible correlation between mtDNAcn in peripheral blood in the first trimester of pregnancy and the PE-IUGR onset. To shed light on this issue, we setup a nested case-control study from a prospective cohort of pregnant women undergoing first-trimester aneuploidies screening. Two groups of patients affected by PE classified according to the clinical phenotype were identified: (1) patients who developed PE-IUGR and (2) patients who developed PE associated with appropriate for gestational age intrauterine fetal growth (PE-AGAf). Controls were women with a physiologic pregnancy matched to cases on the basis of age (+/- 6 months, ratio 2:1). Mitochondrial DNA copy number was quantified using real-time polymerase chain reaction and normalized to nuclear DNA. The median (interquartile range) mtDNAcn in peripheral blood in patients with PE-IUGR (n = 12) and in patients with PE-AGAf (n = 16) was 70 (44-97) and 108 (95-145), respectively (P = .004). Both these values were significantly lower than that detected in the control group (161[133-183], P < .001). The area under the receiver-operator curve for PE-IUGR and PE-AGAf were 0.94 (95% confidence interval [CI]: 0.88-1.00, P < .001) and 0.81 (95%CI: 0.70-0.91, P < .001), respectively. In conclusion, MtDNAcn in peripheral blood resulted significantly lower both in patients affected by PE-IUGR and in those affected by PE-AGAf when compared to controls. The accuracy of this biomarker resulted particularly good in predicting PE-IUGR.
C1 [Busnelli, Andrea; Somigliana, Edgardo; Fedele, Luigi; Ferrazzi, Enrico] Univ Milan, Dept Clin Sci & Community Hlth, Milan, Italy.
   [Busnelli, Andrea; Lattuada, Debora; Ferrari, Stefania; Reschini, Marco; Colciaghi, Barbara; Somigliana, Edgardo; Fedele, Luigi; Ferrazzi, Enrico] Osped Maggiore Policlin, Fdn IRCCS Ca Granda, Milan, Italy.
C3 University of Milan; IRCCS Ca Granda Ospedale Maggiore Policlinico
RP Busnelli, A (corresponding author), Osped Maggiore Policlin, Fdn IRCCS Ca Granda, Infertil Unit, Via M Fanti 6, I-20122 Milan, Italy.
EM andreabusnelli@live.it
RI Reschini, Marco/ABI-2191-2020; colciaghi, barbara/AAC-1420-2020;
   Somigliana, Edgardo/Z-3749-2019; Ferrazzi, Enrico/AAB-9416-2019;
   Lattuada, Debora/C-1671-2016; Busnelli, Andrea/GYV-2136-2022; Ferrari,
   Stefania/AET-1002-2022
OI Lattuada, Debora/0000-0002-4705-7966; colciaghi,
   barbara/0000-0001-5983-565X; Busnelli, Andrea/0000-0001-9870-5241;
   Ferrari, Stefania/0000-0001-8542-4598; Reschini,
   Marco/0000-0002-9868-3043
CR [Anonymous], CIC EDITOR GUIDELINE
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NR 47
TC 20
Z9 22
U1 0
U2 4
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1933-7191
EI 1933-7205
J9 REPROD SCI
JI Reprod. Sci.
PD AUG
PY 2019
VL 26
IS 8
BP 1054
EP 1061
DI 10.1177/1933719118804410
PG 8
WC Obstetrics & Gynecology; Reproductive Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology; Reproductive Biology
GA IM0BH
UT WOS:000477649000004
PM 30296910
DA 2025-06-11
ER

PT J
AU Geijselaers, SLC
   Sep, SJS
   Schram, MT
   van Boxtel, MPJ
   van Sloten, TT
   Roodt, JO
   Henry, RMA
   Reesink, KD
   Schaper, NC
   Dagnelie, PC
   van der Kallen, CJH
   Biessels, GJ
   Stehouwer, CDA
AF Geijselaers, Stefan L. C.
   Sep, Simone J. S.
   Schram, Miranda T.
   van Boxtel, Martin P. J.
   van Sloten, Thomas T.
   Roodt, Jos op Het
   Henry, Ronald M. A.
   Reesink, Koen D.
   Schaper, Nicolaas C.
   Dagnelie, Pieter C.
   van der Kallen, Carla J. H.
   Biessels, Geert Jan
   Stehouwer, Coen D. A.
TI Carotid circumferential wall stress is not associated with cognitive
   performance among individuals in late middle age: The Maastricht Study
SO ATHEROSCLEROSIS
LA English
DT Article
ID INTIMA-MEDIA THICKNESS; METABOLIC SYNDROME; ARTERY ATHEROSCLEROSIS;
   RISK-FACTORS; PART I; IMPAIRMENT; DECLINE; POPULATION; STIFFNESS;
   DEMENTIA
AB Background and aims: Arterial remodelling aims at normalising circumferential wall stress (CWS). Greater CWS in the carotid artery has previously been associated with the prevalence and severity of cerebral small vessel disease, a major cause of ageing-related cognitive decline. Here we test the hypothesis that greater carotid CWS is associated with poorer cognitive performance.
   Methods: We studied 722 individuals (60 +/- 8 years, 55% men, 42.5% highly educated, blood pressure 137 +/- 19/77 +/- 11 mmHg, n = 197 with type 2 diabetes) who completed a neuropsychological assessment and underwent vascular ultrasound to measure the intima-media thickness (IMT) and interadventitial diameter (IAD) of the left common carotid artery at a plaque-free site. From IMT and IAD, lumen diameter (LD) was calculated. These structural measures were then combined with local carotid pulse pressure and brachial mean arterial pressure to obtain a measure of pulsatile (CWSpulsatile) and average (CWSmean) mechanical load on the vessel wall. Cognitive domains assessed were memory, executive function and attention, and processing speed.
   Results: After adjustment for age, sex, and education, regression analyses showed that neither CWSpulsatile nor CWSmean were associated with measures of cognitive performance (p-values >= 0.31). This null association did not differ by age or educational level, and was observed in both individuals with and without carotid plaque, diabetes and/or hypertension. In addition, none of the individual measures of carotid structure (i.e. IMT, IAD, and LD) was related to cognitive performance.
   Conclusions: The present cross-sectional study shows that carotid CWS is not associated with cognitive performance, at least not among relatively highly educated individuals in late middle age with adequately controlled cardiovascular risk factors. (c) 2018 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
C1 [Geijselaers, Stefan L. C.; Sep, Simone J. S.; Schram, Miranda T.; van Sloten, Thomas T.; Roodt, Jos op Het; Henry, Ronald M. A.; Schaper, Nicolaas C.; van der Kallen, Carla J. H.; Stehouwer, Coen D. A.] Maastricht Univ, Med Ctr, Dept Internal Med, POB 5800, NL-6202 AZ Maastricht, Netherlands.
   [Geijselaers, Stefan L. C.; Sep, Simone J. S.; Schram, Miranda T.; van Sloten, Thomas T.; Roodt, Jos op Het; Henry, Ronald M. A.; Schaper, Nicolaas C.; Dagnelie, Pieter C.; van der Kallen, Carla J. H.; Stehouwer, Coen D. A.] Maastricht Univ, CARIM Sch Cardiovasc Dis, Maastricht, Netherlands.
   [Geijselaers, Stefan L. C.; Biessels, Geert Jan] Univ Med Ctr Utrecht, Brain Ctr Rudolf Magnus, Dept Neurol, Utrecht, Netherlands.
   [van Boxtel, Martin P. J.] Maastricht Univ, Med Ctr, Dept Psychiat & Neuropsychol, Maastricht, Netherlands.
   [van Boxtel, Martin P. J.] Maastricht Univ, MHeNS Sch Mental Hlth & Neurosci, Med Ctr, Maastricht, Netherlands.
   [Reesink, Koen D.] Maastricht Univ, Med Ctr, Dept Biomed Engn, Maastricht, Netherlands.
   [Schaper, Nicolaas C.; Dagnelie, Pieter C.] Maastricht Univ, CAPHRI Sch Publ Hlth & Primary Care, Maastricht, Netherlands.
   [Dagnelie, Pieter C.] Maastricht Univ, Dept Epidemiol, Maastricht, Netherlands.
C3 Maastricht University; Maastricht University; Utrecht University;
   Utrecht University Medical Center; Maastricht University; Maastricht
   University; Maastricht University; Maastricht University; Maastricht
   University
RP Geijselaers, SLC (corresponding author), Maastricht Univ, Med Ctr, Dept Internal Med, POB 5800, NL-6202 AZ Maastricht, Netherlands.
EM stefan.geijselaers@gmail.com
RI Schaper, Nicolaas/E-7112-2014; Smulders, YM/AAG-7506-2021; Stehouwer,
   Coen/AAB-3435-2021; Sep, Simone/ITU-7616-2023
OI Stehouwer, Coen/0000-0001-8752-3223; schaper,
   nicolaas/0000-0002-2128-8029; van Sloten, Thomas/0000-0003-2870-482X;
   Reesink, Koen/0000-0003-2354-883X; Schram, Miranda/0000-0001-8113-7604;
   op 't Roodt, Jos/0000-0003-3535-6894; van der Kallen,
   Carla/0000-0003-1468-8793
FU Dutch Heart Association [2010T073]; Vidi grant from ZonMw, The
   Netherlands Organisation for Health Research and Development [91711384];
   European Regional Development Fund via OP-Zuid; Province of Limburg;
   Dutch Ministry of Economic Affairs [31O.041]; Stichting De Weijerhorst
   (Maastricht, the Netherlands); Pearl String Initiative Diabetes
   (Amsterdam, the Netherlands); Cardiovascular Center (CVC, Maastricht,
   the Netherlands); Cardiovascular Research Institute Maastricht (CARIM,
   Maastricht, the Netherlands); School for Public Health and Primary Care
   (CAPHRI, Maastricht, the Netherlands); School for Nutrition, Toxicology
   and Metabolism (NUTRIM, Maastricht, the Netherlands); Stichting Annadal
   (Maastricht, the Netherlands); Health Foundation Limburg (Maastricht,
   the Netherlands); Janssen-Cilag B.V. (Tilburg, the Netherlands); Novo
   Nordisk Farma B.V. (Alphen aan den Rijn, the Netherlands);
   Sanofi-Aventis Netherlands B.V. (Gouda, the Netherlands)
FX The research of GJB is supported by grant 2010T073 from the Dutch Heart
   Association and GJB and SLCG are supported by Vidi grant 91711384 from
   ZonMw, The Netherlands Organisation for Health Research and Development.
   The Maastricht Study was supported by the European Regional Development
   Fund via OP-Zuid, the Province of Limburg, the Dutch Ministry of
   Economic Affairs (grant 31O.041), Stichting De Weijerhorst (Maastricht,
   the Netherlands), the Pearl String Initiative Diabetes (Amsterdam, the
   Netherlands), the Cardiovascular Center (CVC, Maastricht, the
   Netherlands), Cardiovascular Research Institute Maastricht (CARIM,
   Maastricht, the Netherlands), School for Public Health and Primary Care
   (CAPHRI, Maastricht, the Netherlands), School for Nutrition, Toxicology
   and Metabolism (NUTRIM, Maastricht, the Netherlands), Stichting Annadal
   (Maastricht, the Netherlands), Health Foundation Limburg (Maastricht,
   the Netherlands) and by unrestricted grants from Janssen-Cilag B.V.
   (Tilburg, the Netherlands), Novo Nordisk Farma B.V. (Alphen aan den
   Rijn, the Netherlands) and Sanofi-Aventis Netherlands B.V. (Gouda, the
   Netherlands).
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NR 52
TC 8
Z9 9
U1 0
U2 6
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0021-9150
EI 1879-1484
J9 ATHEROSCLEROSIS
JI Atherosclerosis
PD SEP
PY 2018
VL 276
BP 15
EP 22
DI 10.1016/j.atherosclerosis.2018.07.003
PG 8
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Cardiovascular System & Cardiology
GA GR8UA
UT WOS:000443005800003
PM 30006323
OA Green Published
DA 2025-06-11
ER

PT J
AU Vitaliano, PP
   Fitzpatrick, AL
   Williams, LE
   Montano, MA
   Russo, JE
AF Vitaliano, Peter P.
   Fitzpatrick, Annette L.
   Williams, Lee E.
   Montano, Michalina A.
   Russo, Joan E.
TI Demographic-Specific Rates for Life Events in the Cardiovascular Health
   Study and Comparisons With Other Studies
SO INNOVATION IN AGING
LA English
DT Article
DE Education; Gender; Life events; Married; Race; Stress
ID DWELLING OLDER-ADULTS; DEPRESSIVE SYMPTOMS; RISK-FACTORS; GENDER
   DIFFERENCES; METABOLIC SYNDROME; COGNITIVE DECLINE; FINANCIAL STRAIN;
   PHYSICAL HEALTH; STRESS; AGE
AB Purpose of the Study: (1a) We use the Cardiovascular Health Study (CHS), a multi-site heterogeneous sample of Medicare enrollees (N = 5,849) to provide rates for specific life events experienced within 6 months; (1b) We present rates for 29 other studies of community-residing older adults (N = 41,308); (2) For the CHS, we provide demographic-specific rates and predicted probabilities for age [young-old (65-75) vs old-old (= 75)], gender, race, marital status, and education.
   Design/Methods: The CHS sample is 57.6% women, 84.2% white (15.8% black), and 66.3% married. Mean age is 72.8 years (standard deviation [SD] = 5.6, range = 65-100) and education is 13.7 years (SD = 4.8). Life events were interviewer-assessed. Regressions estimated associations of life event rates with demographic groups (e.g., age), controlling for other demographic variables (e.g., gender, etc.).
   Results: (1a) CHS rates ranged from 44.7% (death of someone close) to 1.1% (retirement/work changes). (1b) Most life event studies used total scores and only 5 that met our inclusion criteria used time intervals <1 year; longer intervals were associated with higher rates. (2) In the CHS, the life event for illnesses was related to 5 demographic variables (net the other 4 demographic variables), difficulties caregiving to 4, and worse relationships to 3 demographic variables. Race was related to 8 life events, marital status to 7, education to 6, and age to 4 events.
   Implications: By identifying demographic groups at highest risk for life events, this research focuses on older adults at greatest risk for health problems. These data are necessary for translating research into interventions, practice, and policy.
C1 [Vitaliano, Peter P.; Russo, Joan E.] Univ Washington, Dept Psychiat & Behav Sci, Box 356560, Seattle, WA 98195 USA.
   [Fitzpatrick, Annette L.] Univ Washington, Dept Family Med, Seattle, WA 98195 USA.
   [Fitzpatrick, Annette L.; Montano, Michalina A.] Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA.
   [Williams, Lee E.] Univ Washington, Dept Bioengn, Seattle, WA 98195 USA.
C3 University of Washington; University of Washington Seattle; University
   of Washington; University of Washington Seattle; University of
   Washington; University of Washington Seattle; University of Washington;
   University of Washington Seattle
RP Vitaliano, PP (corresponding author), Univ Washington, Dept Psychiat & Behav Sci, Box 356560, Seattle, WA 98195 USA.
EM pvital@uw.edu
RI Vitaliano, Peter/K-2014-2019
OI Vitaliano, peter P./0000-0003-1598-0868
FU National Institute on Aging [AG023629]; National Heart, Lung, and Blood
   Institute [HHSN268201200036C, HHSN268200800007C, N01 HC55222,
   N01HC85079, N01HC85080, N01HC85081, N01HC85082, N01HC85083, N01HC85086,
   HL080295]
FX This work was supported by AG023629 from the National Institute on Aging
   to the first author and by contracts HHSN268201200036C,
   HHSN268200800007C, N01 HC55222, N01HC85079, N01HC85080, N01HC85081,
   N01HC85082, N01HC85083, N01HC85086, and grant HL080295 from the National
   Heart, Lung, and Blood Institute, with additional contribution from the
   National Institute of Neurological Disorders and Stroke. A full list of
   principal CHS investigators and institutions can be found at
   http://www.chs-nhlbi.org.
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NR 93
TC 5
Z9 5
U1 0
U2 1
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
EI 2399-5300
J9 INNOV AGING
JI Innov. Aging
PD JAN
PY 2018
VL 2
IS 1
DI 10.1093/geroni/igy005
PG 14
WC Geriatrics & Gerontology; Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA HL4LU
UT WOS:000458693700004
PM 30911687
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Cheng, HS
   Yaw, HP
   Ton, SH
   Choy, SM
   Kong, JMXF
   Kadir, KA
AF Cheng, Hong Sheng
   Yaw, Hui Ping
   Ton, So Ha
   Choy, Siew Mei
   Kong, Joana Magdelene Xiao Fang
   Kadir, Khalid Abdul
TI Glycyrrhizic acid prevents high calorie diet-induced metabolic
   aberrations despite the suppression of peroxisome proliferator-activated
   receptor γ expression
SO NUTRITION
LA English
DT Article
DE Adiponectin; Adrenaline; Gluconeogenesis; Glycyrrhizin; Lipoprotein
   lipase; Metabolic syndrome
ID LIPOPROTEIN-LIPASE EXPRESSION; HIGH-SUCROSE DIET; PPAR-GAMMA;
   INSULIN-RESISTANCE; HIGH-FAT; PHOSPHOENOLPYRUVATE CARBOXYKINASE;
   GLYCYRRHETINIC ACID; LIPID DEPOSITION; INDUCED OBESITY; IN-VIVO
AB Objective: To investigate the effects of glycyrrhizic acid supplementation on glucose and lipid metabolism in rodents consuming a high-fat, high-sucrose diet.
   Methods: Twenty-four male, 8-week old Sprague Dawley rats with an initial weight of 160 to 200 g were randomised into three groups (n = 6 for each group): groups A (standard rat chow), B (high fat, high-sucrose diet), and C (high-fat, high-sucrose diet + 100 mg/kg/d of glycyrrhizic acid via oral administration). The rats were treated accordingly for 4 wk. Glycaemic parameters, lipid profile, stress hormones, and adiponectin levels were measured after the treatment. Relative gene expressions of peroxisome proliferator-activated receptor alpha and gamma, lipoprotein lipase as well as gluconeogenic enzymatic activities in different tissues were also determined.
   Results: Consumption of high-fat, high-sucrose diet triggered hyperglycaemia, insulin resistance, and dyslipidemia, which were effectively attenuated by supplementation with glycyrrhizic acid. Glycyrrhizic acid supplementation also effectively reduced circulating adrenaline, alleviated gluconeogenic enzymes overactivity, and promoted the upregulation of lipoprotein lipase expression in the cardiomyocytes and skeletal muscles. A high calorie diet also triggered hypoadiponectinaemia and suppression of peroxisome proliferator-activated receptor gamma expression, which did not improve with glycyrrhizic acid treatment.
   Conclusion: Supplementation with glycyrrhizic acid could alleviate high calorie diet-induced glucose and lipid metabolic dysregulations by reducing circulatory stress hormones, normalizing gluconeogenic enzyme activities, and elevating muscular lipid uptake. The beneficial effects of these bioactivities outweighed the adverse effects caused by diet-induced repression of peroxisome proliferator-activated receptor gamma expression, resulting in the maintenance of lipid and glucose homeostasis. (C) 2016 Elsevier Inc. All rights reserved.
C1 [Cheng, Hong Sheng; Yaw, Hui Ping; Ton, So Ha; Choy, Siew Mei; Kong, Joana Magdelene Xiao Fang] Monash Univ Malaysia, Sch Sci, Selangor Darul Ehsan, Malaysia.
   [Kadir, Khalid Abdul] Monash Univ Malaysia, Sch Med & Hlth Sci, Selangor Darul Ehsan, Malaysia.
C3 Monash University; Monash University Malaysia; Monash University; Monash
   University Malaysia
RP Cheng, HS (corresponding author), Monash Univ Malaysia, Sch Sci, Selangor Darul Ehsan, Malaysia.
EM hsche19@student.monash.edu
RI Cheng, Hong Sheng/AAD-6121-2019
OI Cheng, Hong Sheng/0000-0001-9745-7872
FU School of Science, Monash University Malaysia
FX The work was funded by the School of Science, Monash University
   Malaysia. We would also like to thank Mr. Andrew Leong Kum Leong, Alvin
   Tang Wei Jie, Helena Erin Dodge-Wan, and Soon Zhen Yao for their
   technical support and contributions in the project.
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NR 37
TC 11
Z9 12
U1 1
U2 22
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0899-9007
EI 1873-1244
J9 NUTRITION
JI Nutrition
PD SEP
PY 2016
VL 32
IS 9
BP 995
EP 1001
DI 10.1016/j.nut.2016.02.002
PG 7
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA DT1IP
UT WOS:000381235200012
PM 27130470
DA 2025-06-11
ER

PT J
AU Wu, S
   Kanda, T
   Nakamoto, S
   Jiang, X
   Nakamura, M
   Sasaki, R
   Haga, Y
   Shirasawa, H
   Yokosuka, O
AF Wu, Shuang
   Kanda, Tatsuo
   Nakamoto, Shingo
   Jiang, Xia
   Nakamura, Masato
   Sasaki, Reina
   Haga, Yuki
   Shirasawa, Hiroshi
   Yokosuka, Osamu
TI Cooperative effects of hepatitis B virus and TNF may play important
   roles in the activation of metabolic pathways through the activation of
   NF-B
SO INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
LA English
DT Article
DE endoplasmic reticulum stress; hepatitis B virus; insulin-like growth
   factor binding protein 1
ID INSULIN-RECEPTOR SUBSTRATE-1; FACTOR-BINDING PROTEIN-1;
   NECROSIS-FACTOR-ALPHA; HEPATOCELLULAR-CARCINOMA; IKK-BETA; SIGNALING
   PATHWAY; HUMAN HEPATOCYTES; VIRAL-HEPATITIS; LIVER-DISEASE; KAPPA-B
AB Elevated levels of inflammatory cytokines such as tumor necrosis factor- (TNF-) and interleukin (IL)-1 are often observed in the sera of hepatitis B virus (HBV)-infected patients. It is well known that these cytokines activate nuclear factor-B (NF-B)-signaling, and are associated with endoplasmic reticulum (ER) stress. We investigated whether HBV or HBV X protein (HBx) enhanced the activation of NF-B in the presence of TNF and/or IL-1, and their effects on the expression of metabolic pathway-associated genes. We examined whether HBV or HBx enhanced cytokine-induced activation of NF-B in hepatocytes, using a reporter assay, in the presence or absence of TNF and/or IL-1. The expression of insulin-like growth factor binding protein 1 (IGFBP1), one of the NF-B target genes was also examined. The expression of metabolic pathway-associated genes in HepG2 and HepG2.2.15 cells in the presence or absence of TNF was evaluated by RT-qPCR. Human hepatocytes expressed TNF receptors and IL-1 receptors. NF-B was activated by cooperation between HBx and TNF in human hepatocytes. We observed IGFBP1 expression in HBV infection and that a number of metabolic pathway-associated genes were upregulated in HepG2.2.15 cells, compared with HepG2 cells with or without TNF treatment. We observed the cooperative effects of HBV and TNF which enhanced the activation of NF-B as well as upregulated the expression of metabolic pathway-associated genes in hepatocytes. These effects may be important in the development of HBV-associated metabolic syndrome.
C1 [Wu, Shuang; Kanda, Tatsuo; Jiang, Xia; Nakamura, Masato; Sasaki, Reina; Haga, Yuki; Yokosuka, Osamu] Chiba Univ, Grad Sch Med, Dept Gastroenterol & Nephrol, Chiba 2608677, Japan.
   [Nakamoto, Shingo; Shirasawa, Hiroshi] Chiba Univ, Grad Sch Med, Dept Mol Virol, Chiba 2608677, Japan.
C3 Chiba University; Chiba University
RP Kanda, T (corresponding author), Chiba Univ, Grad Sch Med, Dept Gastroenterol & Nephrol, Chuo Ku, 1-8-1 Inohana, Chiba 2608670, Japan.
EM kandat-cib@umin.ac.jp
RI WU, SHUANG/HRA-0836-2023; Kanda, Tatsuo/AFA-8767-2022
OI Kanda, Tatsuo/0009-0000-8135-342X; Kanda, Tatsuo/0000-0002-1654-5385
FU Ministry of Education, Culture, Sports, Science, and Technology of Japan
   [20345002]; Grants-in-Aid for Scientific Research [26860491, 26430155]
   Funding Source: KAKEN
FX The present study was supported by a KAKEN Grant-in-Aid for Scientific
   Research from the Ministry of Education, Culture, Sports, Science, and
   Technology of Japan (no. 20345002). The authors thank Professor J.
   Miyazaki and Professor A. McLachlan for providing plasmids, and
   Professor R. Ray for providing IHH cells.
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NR 41
TC 9
Z9 9
U1 0
U2 10
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1107-3756
EI 1791-244X
J9 INT J MOL MED
JI Int. J. Mol. Med.
PD AUG
PY 2016
VL 38
IS 2
BP 475
EP 481
DI 10.3892/ijmm.2016.2643
PG 7
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA DT2CQ
UT WOS:000381288800012
PM 27315566
OA Green Submitted, Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Distelmaier, K
   Schrutka, L
   Seidl, V
   Winter, MP
   Wurm, R
   Mangold, A
   Perkmann, T
   Maurer, G
   Adlbrecht, C
   Lang, IM
AF Distelmaier, Klaus
   Schrutka, Lore
   Seidl, Veronika
   Winter, Max P.
   Wurm, Raphael
   Mangold, Andreas
   Perkmann, Thomas
   Maurer, Gerald
   Adlbrecht, Christopher
   Lang, Irene M.
TI Pro-oxidant HDL predicts poor outcome in patients with ST-elevation
   acute coronary syndrome
SO THROMBOSIS AND HAEMOSTASIS
LA English
DT Article
DE STE-ACS; HDL; antioxidant function; outcome
ID HIGH-DENSITY-LIPOPROTEIN; ACUTE MYOCARDIAL-INFARCTION;
   ISCHEMIA-REPERFUSION INJURY; APOLIPOPROTEIN-A-I; OXIDATIVE STRESS;
   PLATELET ACTIVATION; THROMBUS-ASPIRATION; METABOLIC SYNDROME;
   ARTERY-DISEASE; MYELOPEROXIDASE
AB Oxidative stress affects clinical outcome in patients with ST-elevation acute coronary syndrome (STE-ACS). Although high-density lipoprotein (HDL) particles are generally considered protective, deleterious properties of HDL have been observed in patients with acute myocardial infarction. Here, we analysed the association between prooxidant HDL and all-cause mortality in STE-ACS patients. We determined the antioxidant function of HDL in 247 prospectively enrolled patients undergoing primary percutaneous coronary intervention for STE-ACS. Patients were stratified as by a pro-oxidant serum HDL oxidant index (HOI >= 1) or with an antioxidant serum HOI (HOI.<1) capacity. Multivariate regression analysis was used to relate HOI to survival. The median follow-up time was 23 months (IQR 14.4-40.0 months). Pro-oxidant HDL was observed in 44.1 % of STE-ACS patients and was independently associated with all-cause mortality with a hazard ratio of 3.30(95 %CI 1.50-7.27, p = 0.003). Mortality rates were higher in patients with baseline pro-oxidant HDL compared to patients with preserved HDL function at 30 days (11.9% vs 2.2%, p=0.002), and at 4 years (22.9% vs 8.7%, p=0.002). Elevated neutrophil counts were a strong and independent predictor for pro-oxidant HDL with an odds ratio per standard deviation of 1.50 (95 %CI 1.11-2.03, p=0.008), as was history of prior acute myocardial infarction, elevated triglycerides levels and reduced glomerular filtration rate. In conclusion, pro-oxidant HDL represents a strong and independent predictor of long-term as well as short-term all-cause mortality in STE-ACS patients. Elevated neutrophil counts predicted the presence of serum pro-oxidant HDL. The maintenance of HDL functions might be a promising therapeutic target in STE-ACS patients.
C1 [Distelmaier, Klaus; Schrutka, Lore; Seidl, Veronika; Winter, Max P.; Wurm, Raphael; Mangold, Andreas; Maurer, Gerald; Adlbrecht, Christopher; Lang, Irene M.] Med Univ Vienna, Dept Internal Med 2, Div Cardiol, A-1090 Vienna, Austria.
   [Perkmann, Thomas] Med Univ Vienna, Dept Med & Chem Lab Diagnost, A-1090 Vienna, Austria.
   [Adlbrecht, Christopher] Med Univ Vienna, Teaching Hosp, Hietzing Hosp, Dept Internal Med 4,Div Cardiol, A-1090 Vienna, Austria.
C3 Medical University of Vienna; Medical University of Vienna; Hietzing
   Hospital; Medical University of Vienna
RP Lang, IM (corresponding author), Med Univ Vienna, Dept Internal Med 2, Div Cardiol, Waehringer Guertel 18-20, A-1090 Vienna, Austria.
EM irene.lang@meduniwien.ac.at
RI Perkmann, Thomas/JAC-5945-2023; Wurm, Raphael/X-9952-2019; Adlbrecht,
   Christopher/D-3971-2009; Mangold, Andreas/JEZ-9124-2023
OI Perkmann, Thomas/0000-0002-7976-0285; Maurer,
   Gerald/0000-0002-9043-7657; Wurm, Raphael/0000-0003-3027-7775; Mangold,
   Andreas/0000-0003-0029-6852; Adlbrecht, Christopher/0000-0003-3743-3881;
   Schrutka, Lore/0000-0002-2731-2667; Lang, Irene/0000-0003-0485-2692
FU Hans and Blanca Moser Stiftung
FX This project has been funded by the Hans and Blanca Moser Stiftung
   (2014; to KD).
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NR 48
TC 11
Z9 12
U1 0
U2 5
PU SCHATTAUER GMBH-VERLAG MEDIZIN NATURWISSENSCHAFTEN
PI STUTTGART
PA HOLDERLINSTRASSE 3, D-70174 STUTTGART, GERMANY
SN 0340-6245
J9 THROMB HAEMOSTASIS
JI Thromb. Haemost.
PD JUL
PY 2015
VL 114
IS 1
BP 133
EP 138
DI 10.1160/TH14-10-0834
PG 6
WC Hematology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Hematology; Cardiovascular System & Cardiology
GA CM2YH
UT WOS:000357547800020
PM 25831998
DA 2025-06-11
ER

PT J
AU Bullon, P
   Battino, M
   Varela-Lopez, A
   Perez-Lopez, P
   Granados-Principal, S
   Ramirez-Tortosa, MC
   Ochoa, JJ
   Cordero, MD
   Gonzalez-Alonso, A
   Ramirez-Tortosa, CL
   Rubini, C
   Zizzi, A
   Quiles, JL
AF Bullon, Pedro
   Battino, Maurizio
   Varela-Lopez, Alfonso
   Perez-Lopez, Patricia
   Granados-Principal, Sergio
   Ramirez-Tortosa, Maria C.
   Ochoa, Julio J.
   Cordero, Mario D.
   Gonzalez-Alonso, Adrian
   Ramirez-Tortosa, Cesar L.
   Rubini, Corrado
   Zizzi, Antonio
   Quiles, Jose L.
TI Diets Based on Virgin Olive Oil or Fish Oil but Not on Sunflower Oil
   Prevent Age-Related Alveolar Bone Resorption by Mitochondrial-Related
   Mechanisms
SO PLOS ONE
LA English
DT Article
ID POLYUNSATURATED FATTY-ACIDS; OXIDATIVE STRESS; METABOLIC SYNDROME; DNA
   DELETION; PERIODONTITIS; N-3; INTERLEUKIN-1-BETA; SUPPLEMENTATION;
   ASSOCIATION; EXPRESSION
AB Background/Objectives: Aging enhances frequency of chronic diseases like cardiovascular diseases or periodontitis. Here we reproduced an age-dependent model of the periodontium, a fully physiological approach to periodontal conditions, to evaluate the impact of dietary fat type on gingival tissue of young (6 months old) and old (24 months old) rats.
   Methods/Findings: Animals were fed life-long on diets based on monounsaturated fatty acids (MUFA) as virgin olive oil, n-6 polyunsaturated fatty acids (n-6PUFA), as sunflower oil, or n-3PUFA, as fish oil. Age-related alveolar bone loss was higher in n-6PUFA fed rats, probably as a consequence of the ablation of the cell capacity to adapt to aging. Gene expression analysis suggests that MUFA or n-3PUFA allowed mitochondria to maintain an adequate turnover through induction of biogenesis, autophagy and the antioxidant systems, and avoiding mitochondrial electron transport system alterations.
   Conclusions: The main finding is that the enhanced alveolar bone loss associated to age may be targeted by an appropriate dietary treatment. The mechanisms involved in this phenomenon are related with an ablation of the cell capacity to adapt to aging. Thus, MUFA or n-3PUFA might allow mitochondrial maintaining turnover through biogenesis or autophagy. They might also be able to induce the corresponding antioxidant systems to counteract age-related oxidative stress, and do not inhibit mitochondrial electron transport chain. From the nutritional and clinical point of view, it is noteworthy that the potential treatments to attenuate alveolar bone loss (a feature of periodontal disease) associated to age could be similar to some of the proposed for the prevention and treatment of cardiovascular diseases, a group of pathologies recently associated with age-related periodontitis.
C1 [Bullon, Pedro] Univ Seville, Sch Dent, Dept Periodontol, Seville, Spain.
   [Battino, Maurizio] Univ Politecn Marche, Dipartimento Sci Clin Specialist & Odontostomatol, Ancona, Italy.
   [Varela-Lopez, Alfonso; Perez-Lopez, Patricia; Ochoa, Julio J.; Gonzalez-Alonso, Adrian; Quiles, Jose L.] Univ Granada, Dept Physiol, Inst Nutr & Food Technol Jose Mataix Verdu, Granada, Spain.
   [Granados-Principal, Sergio; Ramirez-Tortosa, Maria C.] Univ Granada, Inst Nutr & Food Technol Jose Mataix Verdu, Dept Biochem & Mol Biol 2, Granada, Spain.
   [Cordero, Mario D.] Univ Seville, Dept Citol & Histol Normal & Patol, Seville, Spain.
   [Ramirez-Tortosa, Cesar L.] Complejo Hosp Jaen, Dept Pathol, Jaen, Spain.
   [Rubini, Corrado; Zizzi, Antonio] Univ Politecn Marche, Dipartimento Sci Biomed Sanita Pubbl, Ancona, Italy.
C3 University of Sevilla; Marche Polytechnic University; University of
   Granada; University of Granada; University of Sevilla; Complejo
   Hospitalario de Jaen; Marche Polytechnic University
RP Battino, M (corresponding author), Univ Politecn Marche, Dipartimento Sci Clin Specialist & Odontostomatol, Ancona, Italy.
EM m.a.battino@univpm.it
RI Quiles, Jose L./C-6911-2013; Battino, Maurizio/E-6103-2012;
   Varela-Lopez, Alfonso/F-8055-2016; Cordero, Mario D./L-8006-2014;
   Bullon, Pedro/E-6319-2010; Granados-Principal, Sergio/B-4987-2014;
   Ochoa, Julio/L-8733-2014; Ramirez-Tortosa, Cesar/F-2055-2016
OI Quiles, Jose L./0000-0002-9048-9086; Zizzi, Antonio/0000-0001-5253-693X;
   Battino, Maurizio/0000-0002-7250-1782; Varela-Lopez,
   Alfonso/0000-0002-0504-5086; Cordero, Mario D./0000-0003-0151-3644;
   Bullon, Pedro/0000-0003-4873-4196; Granados-Principal,
   Sergio/0000-0001-8773-9489; Ochoa, Julio/0000-0001-8976-6296;
   Ramirez-Tortosa, Cesar/0000-0002-3302-707X
FU Spanish Ministry of Education and Science [AGL2008-01057]; Autonomous
   Government of Andalusia [AGR832]
FX This study was supported by I+D grants from the Spanish Ministry of
   Education and Science (AGL2008-01057) and the Autonomous Government of
   Andalusia (AGR832). The funders had no role in study design, data
   collection and analysis, decision to publish, or preparation of the
   manuscript.
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NR 44
TC 43
Z9 46
U1 0
U2 45
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD SEP 16
PY 2013
VL 8
IS 9
AR e74234
DI 10.1371/journal.pone.0074234
PG 11
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 219GJ
UT WOS:000324494000106
PM 24066124
OA gold, Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Egert, S
   Boesch-Saadatmandi, C
   Wolffram, S
   Rimbach, G
   Müller, MJ
AF Egert, Sarah
   Boesch-Saadatmandi, Christine
   Wolffram, Siegfried
   Rimbach, Gerald
   Mueller, Manfred J.
TI Serum Lipid and Blood Pressure Responses to Quercetin Vary in Overweight
   Patients by Apolipoprotein E Genotype
SO JOURNAL OF NUTRITION
LA English
DT Article
ID INHIBITS PLATELET-AGGREGATION; E GENE POLYMORPHISM; APOE GENOTYPE;
   OXIDATIVE STRESS; ESSENTIAL COMPONENTS; ACTIVATION PATHWAY;
   HEART-DISEASE; EXPRESSION; RISK; SUPPLEMENTATION
AB Our objective was to examine the effect of a quercetin supplementation on blood pressure, lipid metabolism, markers of oxidative stress, inflammation, and body composition in an at-risk population of 93 overweight-obese volunteers aged 25-65 y with metabolic syndrome traits in relation to apolipoprotein (apo) E genotype. Participants were randomized to receive 150 mg/d quercetin in a double-blinded, placebo-controlled, crossover trial with 6-wk treatment periods separated by a 5-wk washout period. Retrospectively, 5 apoE genotype variants were found (epsilon 2/epsilon 3, n = 3; epsilon 3/epsilon 3, n = 60; epsilon 3/epsilon 4, n = 23; epsilon 2/epsilon 4 n = 4; and epsilon 4/epsilon 4, n = 3). Participants were classified into the following 3 apoE phenotypes: apoE2 In = 3), apoE3 In = 60), and apoE4 (n = 26). Data were analyzed for apoE3 and apoE4 subgroups. Quercetin decreased systolic blood pressure by 3.4 mm Hg (P < 0.01) in the apoE3 group, whereas no significant effect was observed in the apoE4 group. Quercetin decreased serum HDL cholesterol (P < 0.01) and apoA1 (P < 0.01) and increased the LDL:HDL cholesterol ratio (P < 0.05) in the apoE4 subgroup, whereas the apoE3 subgroup had no significant changes in these variables. Quercetin significantly decreased plasma oxidized LDL and tumor necrosis factor-alpha in the apoE3 and apoE4 groups, whereas no significant inter-group differences were found. Serum C-reactive protein and nutritional status (body weight, waist circumference, fat mass, fat-free mass) were unaffected compared with placebo. In conclusion, quercetin exhibited blood pressure-lowering effects in overweight-obese carriers of the apo epsilon 3/epsilon 3 genotype but not in carriers of the epsilon 4 allele. Furthermore, quercetin supplementation resulted in a reduction in HDL cholesterol and apoA1 in apo epsilon 4 carriers. J. Nutr. 140: 278-284, 2010.
C1 [Egert, Sarah; Mueller, Manfred J.] Univ Kiel, Dept Human Nutr, Inst Human Nutr & Food Sci, D-24105 Kiel, Germany.
   [Egert, Sarah] Univ Bonn, Inst Nutr & Food Sci, D-53115 Bonn, Germany.
   [Boesch-Saadatmandi, Christine; Rimbach, Gerald] Univ Kiel, Dept Food Sci, Inst Human Nutr & Food Sci, D-24098 Kiel, Germany.
   [Wolffram, Siegfried] Univ Kiel, Inst Anim Nutr & Physiol, D-24118 Kiel, Germany.
C3 University of Kiel; University of Bonn; University of Kiel; University
   of Kiel
RP Müller, MJ (corresponding author), Univ Kiel, Dept Human Nutr, Inst Human Nutr & Food Sci, D-24105 Kiel, Germany.
EM mmueller@nutrfoodsc.uni-kiel.de
RI Rimbach, Gerald/A-7178-2011; Bosch, Christine/AGL-4328-2022
OI Rimbach, Gerald/0000-0001-7888-4684; Bosch,
   Christine/0000-0001-6705-5709
FU German Federal Ministry of Education and Research [BMBF 0313856A]
FX Supported by the German Federal Ministry of Education and Research (BMBF
   0313856A) within the project "Functional Foods for Vascular Health -
   from Nutraceuticals to Personalised Diets."
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NR 46
TC 152
Z9 164
U1 0
U2 15
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0022-3166
EI 1541-6100
J9 J NUTR
JI J. Nutr.
PD FEB
PY 2010
VL 140
IS 2
BP 278
EP 284
DI 10.3945/jn.109.117655
PG 7
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 546GN
UT WOS:000273799300009
PM 20032478
OA Bronze
DA 2025-06-11
ER

PT J
AU Thorn, SR
   Regnault, TRH
   Brown, LD
   Rozance, PJ
   Keng, J
   Roper, M
   Wilkening, RB
   Hay, WW
   Friedman, JE
AF Thorn, Stephanie R.
   Regnault, Timothy R. H.
   Brown, Laura D.
   Rozance, Paul J.
   Keng, Jane
   Roper, Michael
   Wilkening, Randall B.
   Hay, William W., Jr.
   Friedman, Jacob E.
TI Intrauterine Growth Restriction Increases Fetal Hepatic Gluconeogenic
   Capacity and Reduces Messenger Ribonucleic Acid Translation Initiation
   and Nutrient Sensing in Fetal Liver and Skeletal Muscle
SO ENDOCRINOLOGY
LA English
DT Article
ID UNFOLDED PROTEIN RESPONSE; INSULIN-RESISTANCE; MATERNAL UNDERNUTRITION;
   PLACENTAL INSUFFICIENCY; DEVELOPMENTAL ORIGINS; ENDOPLASMIC-RETICULUM;
   GLUCOSE-HOMEOSTASIS; SIGNALING PATHWAYS; METABOLIC SYNDROME; COACTIVATOR
   PGC-1
AB Expression of key metabolic genes and proteins involved in mRNA translation, energy sensing, and glucose metabolism in liver and skeletal muscle were investigated in a late-gestation fetal sheep model of placental insufficiency intrauterine growth restriction (PI-IUGR). PI-IUGR fetuses weighed 55% less; had reduced oxygen, glucose, isoleucine, insulin, and IGF-I levels; and had 40% reduction in net branched chain amino acid uptake. In PI-IUGR skeletal muscle, levels of insulin receptor were increased 80%, whereas phosphoinositide-3 kinase (p85) and protein kinase B (AKT2) were reduced by 40%. Expression of eukaryotic initiation factor-4e was reduced 45% in liver, suggesting a unique mechanism limiting translation initiation in PI-IUGR liver. There was either no change (AMP activated kinase, mammalian target of rapamycin) or a paradoxical decrease (protein phosphatase 2A, eukaryotic initiation factor-2 alpha) in activation of major energy and cell stress sensors in PI-IUGR liver and skeletal muscle. A 13-to 20-fold increase in phosphoenolpyruvate carboxykinase and glucose 6 phosphatase mRNA expression in the PI-IUGR liver was-associated with a 3-fold increase in peroxisome proliferator-activated receptor-gamma coactivator-1 alpha mRNA and increased phosphorylation of cAMP response element binding protein. Thus PI-IUGR is-associated with reduced branched chain amino acid uptake and growth factors, yet up-regulation of proximal insulin signaling and a marked increase in the gluconeogenic pathway. Lack of activation of several energy and stress sensors in fetal liver and skeletal muscle, despite hypoxia and low energy status, suggests a novel strategy for survival in the PI-IUGR fetus but with potential maladaptive consequences for reduced nutrient sensing and insulin sensitivity in postnatal life. (Endocrinology 150: 3021-3030, 2009)
C1 [Thorn, Stephanie R.; Regnault, Timothy R. H.; Brown, Laura D.; Rozance, Paul J.; Keng, Jane; Roper, Michael; Wilkening, Randall B.; Hay, William W., Jr.; Friedman, Jacob E.] Univ Colorado Denver, Dept Pediat, Aurora, CO 80045 USA.
   [Friedman, Jacob E.] Univ Colorado Denver, Dept Biochem & Mol Genet, Aurora, CO 80045 USA.
C3 University of Colorado System; University of Colorado Anschutz Medical
   Campus; Children's Hospital Colorado; Children's Hospital Colorado;
   University of Colorado System; University of Colorado Anschutz Medical
   Campus
RP Friedman, JE (corresponding author), Univ Colorado Denver, Dept Pediat, Mail Stop F-8106,POB 6511, Aurora, CO 80045 USA.
EM jed.friedman@ucdenver.edu
RI Regnault, Timothy/J-8902-2014; Brown, Laura/LBH-3404-2024
OI Regnault, Timothy/0000-0003-1930-8358; Wesolowski,
   Stephanie/0000-0001-7523-0394
FU National Institutes of Health [HD41505-02, DK52138, DKF32-082207,
   K068590]
FX This work was supported by National Institutes of Health Grants
   HD41505-02 (to T. R. H. R. and R. B. W.), DK52138 (to W. W. H.),
   DKF32-082207 (to S. R. T.), and K068590 (to J. E. F.).
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NR 75
TC 130
Z9 151
U1 0
U2 7
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0013-7227
EI 1945-7170
J9 ENDOCRINOLOGY
JI Endocrinology
PD JUL
PY 2009
VL 150
IS 7
BP 3021
EP 3030
DI 10.1210/en.2008-1789
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 467ZB
UT WOS:000267781300008
PM 19342452
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Joshi, AA
   Hegde, MV
   Zanwar, AA
AF Joshi, Asavari Anirudha
   Hegde, Mahabaleshwar Vishnu
   Zanwar, Anand Arvind
TI Potential of flaxseed oil blends to modulate tissue fatty acid
   composition and determination of safety parameters in Wistar rats
SO LIPIDS
LA English
DT Article
DE edible oils; fatty acid analysis; Omega-3 fatty acid; Omega-6 fatty
   acids; plasma lipids
ID ALPHA-LINOLENIC ACID; METABOLIC SYNDROME; OXIDATIVE STRESS;
   VEGETABLE-OILS; LEPTIN LEVELS; SERUM-LIPIDS; COCONUT OIL;
   SUPPLEMENTATION; INFLAMMATION; DIET
AB Non-communicable diseases (NCD) are associated with inflammation and oxidative stress which is further associated with omega-6 (omega 6) and omega-3 (omega 3) fatty acid (FA) imbalance favoring omega 6 FA. By improving omega 3 FA consumption, this imbalance can be altered to control NCD. Previously we have reported blends of flaxseed oil (FSO, omega 3 FA) with palm olein (PO) or coconut oil (CO) were thermo-oxidatively stable with good storage stability and could improve omega 6:omega 3 ratio in cell lines. In the present study safety of these blends along with their efficacy to improve tissue FA composition particularly omega 6:omega 3 ratio was evaluated in Wistar rats. Institutional ethics committee approval was obtained initially. Wistar rats were supplemented with individual oils or blends (FSO with PO or CO, 20:80 by volume, 1.0 mL/day/200 gm body weight) for 3 months. Throughout the study period, there were no adverse effect of blends on feed intake and body weight gain. After 3 months, blood and serum were subjected for hematological, biochemical assessment. Vital organs were harvested for histopathological and FA composition investigations. Hematological, biochemical, and tissue histopathological parameters were comparable with Control (group receiving only normal diet). Interestingly serum lipid profile was improved by the blend supplementation. Except brain, FA composition was altered in liver, heart, adipose tissue, and RBC with lowering of omega 6:omega 3 ratio but there was no favorable effect on inflammatory markers and adipokines in the blend supplemented groups. Thus, to conclude, FSO blends with PO or CO were able to lower tissue omega 6:omega 3 ratio without adverse effects.
C1 [Joshi, Asavari Anirudha; Hegde, Mahabaleshwar Vishnu; Zanwar, Anand Arvind] Bharati Vidyapeeth, Ctr Innovat Nutr Hlth Dis, Interact Res Sch Hlth Affairs, Pune 411043, India.
   Bharati Vidyapeeth Deemed Univ, Interact Res Sch Hlth Affairs, Ctr Innovat Nutr Hlth Dis, Pune 411, Maharashtra, India.
C3 Bharati Vidyapeeth Deemed University; Bharati Vidyapeeth Deemed
   University
RP Zanwar, AA (corresponding author), Bharati Vidyapeeth, Ctr Innovat Nutr Hlth Dis, Interact Res Sch Hlth Affairs, Pune 411043, India.
EM anand.zanwar@bharatividyapeeth.edu
RI Zanwar, Dr. Anand/KHD-2017-2024
OI Zanwar, Dr. Anand/0000-0002-0858-7075
FU Bharati Vidyapeeth
FX We are thankful to Bharati Vidyapeeth (Deemed to be University) for
   providing financial support for this study. We are also thankful to Mr.
   Yogesh Badhe, Mr. Pramod Farde and Mrs. Deepali Garud for assisting in
   handling various instruments.
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NR 73
TC 0
Z9 0
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0024-4201
EI 1558-9307
J9 LIPIDS
JI Lipids
PD MAY
PY 2025
VL 60
IS 3
BP 125
EP 141
DI 10.1002/lipd.12431
EA JAN 2025
PG 17
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA 2JH4G
UT WOS:001394242800001
PM 39797657
DA 2025-06-11
ER

PT J
AU Huh, JY
   Seo, EY
   Lee, HB
   Ha, H
AF Huh, Joo Young
   Seo, Eun-Young
   Lee, Hi Bahl
   Ha, Hunjoo
TI GLUCOSE-BASED PERITONEAL DIALYSIS SOLUTION SUPPRESSES ADIPONECTIN
   SYNTHESIS THROUGH OXIDATIVE STRESS IN AN EXPERIMENTAL MODEL OF
   PERITONEAL DIALYSIS
SO PERITONEAL DIALYSIS INTERNATIONAL
LA English
DT Article
DE Adiponectin; N-acetylcysteine; reactive oxygen species
ID STAGE RENAL-DISEASE; MOLECULAR-WEIGHT ADIPONECTIN; CHRONIC
   KIDNEY-DISEASE; METABOLIC SYNDROME; HEMODIALYSIS-PATIENTS;
   CARDIOVASCULAR-DISEASE; PLASMA ADIPONECTIN; GENE-EXPRESSION;
   ADIPOSE-TISSUE; RISK-FACTORS
AB Objective: Accumulation of visceral fat is one of the major risk factors for the development of cardiovascular disease in peritoneal dialysis (PD) patients. Adiponectin, an adipokine commonly regarded as a negative indicator of metabolic disease, is reported to be downregulated in its gene level in end-stage renal disease patients. Since excessive fat deposit is involved in increased reactive oxygen species (ROS), PD solution (PDS) may contribute to ROS production, resulting in dysregulation of adiponectin. In this study, we tested our hypothesis that oxidative stress induced by PDS may play a role in the regulation of adiponectin.
   Methods: Commercial PDS containing 3.86% glucose (20 - 30 mL) was administered to SD rats for 12 weeks with and without N-acetylcysteine (NAC; 10 mmol/L). ELISA was used to quantify adiponectin in plasma and spent dialysate. For in vitro studies, fully differentiated 3T3-L1 adipocytes and adipocytes isolated from abdominal fat were treated with a high glucose solution, PDS, and H2O2. Adiponectin levels in the conditioned media were measured by ELISA and immunoblot assays. The mRNA levels of adiponectin in mature adipocytes were examined using real-time RT-PCR.
   Results: The levels of adiponectin in plasma and spent dialysate were significantly downregulated by PDS and this effect was suppressed by NAC. In 3T3-L1 adipocytes, adiponectin secretion was inhibited by 50 mmol/L glucose, PDS diluted 2-fold, and H2O2 (200 mu mol/L). In addition, H2O2 downregulated expression of adiponectin mRNA and secretion of adiponectin oligomer complexes.
   Conclusions: Our data suggest that ROS induced by conventional glucose-based PDS may contribute to pathophysiological changes in abdominal fat and down-regulate adiponectin secreted from adipocytes during long-term PD.
C1 [Huh, Joo Young; Seo, Eun-Young; Ha, Hunjoo] Ewha Womans Univ, Dept Bioinspired Sci, Div Life & Pharmaceut Sci, Coll Pharm, Seoul 120750, South Korea.
   [Lee, Hi Bahl] Kims Clin, Miryang, South Korea.
   [Lee, Hi Bahl] Dialysis Unit, Miryang, South Korea.
C3 Ewha Womans University
RP Ha, H (corresponding author), Ewha Womans Univ, Dept Bioinspired Sci, Div Life & Pharmaceut Sci, Coll Pharm, 11-1 Daehyun Dong, Seoul 120750, South Korea.
EM hha@ewha.ac.kr
OI Ha, Hunjoo/0000-0002-5601-1265
FU Seoul Development Institute [ST090834]; National Research Foundation,
   Korea [E00022, R15-2006-020-00000-0, R31-2008-000-10010-0]; Brain Korea
   21 Project
FX This work was supported in part by grants ST090834 from the Seoul
   Development Institute and E00022, R15-2006-020-00000-0, and
   R31-2008-000-10010-0 from the National Research Foundation, Korea. HJ
   Huh and EY Seo were supported by the Brain Korea 21 Project.
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NR 41
TC 15
Z9 17
U1 0
U2 2
PU MULTIMED INC
PI TORONTO
PA 66 MARTIN ST, TORONTO, ON L9T 2R2, CANADA
SN 0896-8608
J9 PERITON DIALYSIS INT
JI Perit. Dial. Int.
PD JAN-FEB
PY 2012
VL 32
IS 1
BP 20
EP 28
DI 10.3747/pdi.2009.00228
PG 9
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 888ID
UT WOS:000299996200005
PM 20798331
OA Green Published
DA 2025-06-11
ER

PT J
AU Russo, I
   Del Mese, P
   Doronzo, G
   Mattiello, L
   Viretto, M
   Bosia, A
   Anfossi, G
   Trovati, M
AF Russo, I.
   Del Mese, P.
   Doronzo, G.
   Mattiello, L.
   Viretto, M.
   Bosia, A.
   Anfossi, G.
   Trovati, M.
TI Resistance to the nitric oxide/cyclic guanosine 5′-monophosphate/protein
   kinase G pathway in vascular smooth muscle cells from the obese Zucker
   rat, a classical animal model of insulin resistance:: Role of oxidative
   stress
SO ENDOCRINOLOGY
LA English
DT Article
ID DEPENDENT PROTEIN-KINASE; SOLUBLE GUANYLYL CYCLASE;
   VASODILATOR-STIMULATED PHOSPHOPROTEIN; CYCLIC-NUCLEOTIDE
   PHOSPHODIESTERASES; METABOLIC SYNDROME; SKELETAL-MUSCLE; OXIDE SYNTHASE;
   IN-VIVO; ENDOTHELIAL DYSFUNCTION; PLATELET RESISTANCE
AB Some in vivo and ex vivo studies demonstrated a resistance to the vasodilating effects of nitric oxide (NO) in insulin-resistant states and, in particular, obese Zucker rats (OZR). To evaluate the biochemical basis of this phenomenon, we aimed to identify defects of the NO/cGMP/cGMP-dependent protein kinase (PKG) pathway in cultured vascular smooth muscle cells (VSMCs) from OZR and lean Zucker rats (LZR) by measuring: 1) NO donor ability to increase cGMP in the absence and presence of inhibitors of soluble guanylate cyclase (sGC) and phosphodiesterases (PDEs); 2) NO and cGMP ability to induce, via PKG, vasodilator-stimulated phosphoprotein ( VASP) phosphorylation at serine 239 and PDE5 activity; 3) protein expression of sGC, PKG, total VASP, and PDE5; 4) superoxide anion concentrations and ability of antioxidants (superoxide dismutase+catalase and amifostine) to influence the NO/cGMP/PKG pathway activation; and 5) hydrogen peroxide influence on PDE5 activity and VASP phosphorylation. VSMCs from OZR vs. LZR showed: 1) baseline cGMP concentrations higher, at least in part owing to reduced catabolism by PDEs; 2) impairment of NO donor ability to increase cGMP, even in the presence of PDE inhibitors, suggesting a defect in the NO-induced sGC activation; 3) reduction of NO and cGMP ability to activate PKG, indicated by the impaired ability to phosphorylate VASP at serine 239 and to increase PDE5 activity via PKG; 4) similar baseline protein expression of sGC, PKG, total VASP, and PDE5; and 5) higher levels of superoxide anion. Antioxidants partially prevented the defects of the NO/ cGMP/PKG pathway observed in VSMCs from OZR, which were reproduced by hydrogen peroxide in VSMCs from LZR, suggesting the pivotal role of oxidative stress.
C1 [Russo, I.; Del Mese, P.; Doronzo, G.; Mattiello, L.; Viretto, M.; Anfossi, G.; Trovati, M.] Univ Turin, San Luigi Gonzaga Hosp, Dept Clin & Biol Sci, Diabet Unit, I-10043 Orbassano, TO, Italy.
   [Bosia, A.] Univ Turin, Dept Genet Biol & Med Chem, I-10126 Turin, Italy.
C3 University of Turin; Azienda Ospedaliero-Universitaria San Luigi
   Gonzaga; University of Turin
RP Trovati, M (corresponding author), Univ Turin, San Luigi Gonzaga Hosp, Dept Clin & Biol Sci, Diabet Unit, I-10043 Orbassano, TO, Italy.
EM mariella.trovati@unito.it
RI Doronzo, Gabriella/AAC-4953-2022; Russo, Isabella/AAC-5779-2020
OI Russo, Isabella/0000-0002-2921-1763; TROVATI,
   MARIELLA/0000-0003-4397-8060; Doronzo, Gabriella/0000-0002-3693-8178
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NR 48
TC 40
Z9 42
U1 0
U2 7
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0013-7227
EI 1945-7170
J9 ENDOCRINOLOGY
JI Endocrinology
PD APR
PY 2008
VL 149
IS 4
BP 1480
EP 1489
DI 10.1210/en.2007-0920
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 278DO
UT WOS:000254264100007
PM 18079207
OA Bronze
DA 2025-06-11
ER

PT J
AU Bagherniya, M
   Nobili, V
   Blesso, CN
   Sahebkar, A
AF Bagherniya, Mohammad
   Nobili, Valerio
   Blesso, Christopher N.
   Sahebkar, Amirhossein
TI Medicinal plants and bioactive natural compounds in the treatment of
   non-alcoholic fatty liver disease: A clinical review
SO PHARMACOLOGICAL RESEARCH
LA English
DT Review
DE NAFLD; Herbal bioactives; Lifestyle modification; Therapeutic agent
ID CHLORELLA-VULGARIS SUPPLEMENTATION; CURCUMINOIDS-PIPERINE COMBINATION;
   CHRONIC PULMONARY COMPLICATIONS; IMPROVES INSULIN-RESISTANCE; SYSTEMIC
   OXIDATIVE STRESS; E-PHOSPHOLIPID COMPLEX; NECROSIS-FACTOR-ALPHA;
   C-REACTIVE PROTEIN; GREEN TEA; MOLECULAR-MECHANISMS
AB Non-alcoholic fatty liver disease (NAFLD) is a major cause of liver diseases, and is closely related to metabolic syndrome and its related conditions, diabetes mellitus and dyslipidemia. On the other hand, NAFLD as a multisystem disease increases the risk of several chronic diseases include type 2 diabetes mellitus, cardiovascular disease (CVD), and chronic kidney disease. The main objective was to review the efficacy of bioactive natural compounds assessed by clinical trials. Search literature using four databases (PubMed, EBSCO, Web of Science, and Ovid Medline) to review publications that focused on the impact of bioactive natural compounds in NAFLD treatment. Due to the lack of effective pharmacological treatments available for NAFLD, lifestyle modifications such as following a healthy diet, vigorous physical activity, and weight reduction remain the first line of treatment for NAFLD. However, due to the poor adherence to this type of treatment, especially for long-term weight loss diets some of which may have harmful effects on the liver, finding novel therapeutic agents for NAFLD treatment and/or preventing NAFLD progression has garnered significant interest. Although the therapeutic agents of NAFLD treatment have been reviewed previously, to date, no summary has been conducted of clinical trials examining the effects of herbal compounds on NAFLD-related biomarkers. This review highlights the beneficial role of herbal bioactives and medicinal plants in NAFLD treatment, particularly as complementary to a healthy lifestyle. All natural products described in this review seem to have some benefits to improve oxidative stress, cellular inflammation and insulin-resistance, which always remain as the "primum movens" of NAFLD pathogenesis. (C) 2017 Elsevier Ltd. All rights reserved.
C1 [Bagherniya, Mohammad] Mashhad Univ Med Sci, Fac Med, Dept Nutr, Student Res Comm, Mashhad, Iran.
   [Nobili, Valerio] IRCCS, Bambino Gesu Childrens Hosp, Hepatometab Dis Unit, Rome, Italy.
   [Blesso, Christopher N.] Univ Connecticut, Dept Nutr Sci, Storrs, CT USA.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Neurogen Inflammat Res Ctr, Mashhad, Iran.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Biotechnol Res Ctr, Mashhad 9177948564, Iran.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Sch Pharm, Mashhad, Iran.
C3 Mashhad University of Medical Sciences; IRCCS Bambino Gesu; University
   of Connecticut; Mashhad University of Medical Sciences; Mashhad
   University of Medical Sciences; Mashhad University of Medical Sciences
RP Sahebkar, A (corresponding author), Mashhad Univ Med Sci, Sch Med, Dept Med Biotechnol, Mashhad, Iran.
EM sahebkara@mums.ac.ir
RI Sahebkar, Amirhossein/B-5124-2018; Blesso, Christopher/N-9495-2014;
   Nobili, Valerio/K-8670-2018
OI Bagherniya, Mohammad/0000-0002-5861-6129
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NR 175
TC 174
Z9 182
U1 3
U2 89
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 1043-6618
EI 1096-1186
J9 PHARMACOL RES
JI Pharmacol. Res.
PD APR
PY 2018
VL 130
BP 213
EP 240
DI 10.1016/j.phrs.2017.12.020
PG 28
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA GG9JN
UT WOS:000433016900022
PM 29287685
DA 2025-06-11
ER

PT J
AU Nishino, T
   Matsunaga, R
   Jikihara, H
   Uchida, M
   Maeda, A
   Qi, GY
   Abe, T
   Kiyonari, H
   Tashiro, S
   Inagaki-Ohara, K
   Shimamoto, F
   Konishi, H
AF Nishino, Tasuku
   Matsunaga, Ryota
   Jikihara, Hiroshi
   Uchida, Moe
   Maeda, Akane
   Qi, Guangying
   Abe, Takaya
   Kiyonari, Hiroshi
   Tashiro, Satoshi
   Inagaki-Ohara, Kyoko
   Shimamoto, Fumio
   Konishi, Hiroaki
TI Antagonizing effect of CLPABP on the function of HuR as a regulator of
   ARE-containing leptin mRNA stability and the effect of its depletion on
   obesity in old male mouse
SO BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
LA English
DT Article
DE Cardiolipin; Mitochondria; Obesity; RNA granule; mRNA stability;
   Knockout mouse
ID PHOSPHATIDIC-ACID; MITOCHONDRIAL DYNAMICS; PIRNA BIOGENESIS; OXIDATIVE
   STRESS; BINDING-PROTEINS; NUAGE FORMATION; MICE; SPERMATOGENESIS;
   METABOLISM; EXPRESSION
AB Cardiolipin and phosphatidic acid-binding protein (CLPABP) is a pleckstrin homology domain-containing protein and is localized on the surface of mitochondria of cultured cells as a large protein-RNA complex. To analyze the physiological functions of CLPABP, we established and characterized a CLPABP knockout (KO) mouse. Although expression levels of CLPABP transcripts in the developmental organs were high, CLPABP KO mice were normal at birth and grew normally when young. However, old male mice presented a fatty phenotype, similar to that seen in metabolic syndrome, in parallel with elevated male- and age-dependent CLPABP gene expression. One of the reasons for this obesity in CLPABP KO mice is dependence on increases in leptin concentration in plasma. The leptin transcripts were also upregulated in the adipose tissue of KO mice compared with wild-type (WT) mice. To understand the difference in levels of the transcriptional product, we focused on the effect of CLPABP on the stability of mRNA involving an AU-rich element (ARE) in its 3'UTR dependence on the RNA stabilizer, human antigen R (HuR), which is one of the CLPABP-binding proteins. Increase in stability of ARE-containing mRNAs of leptin by HuR was antagonized by the expression of CLPABP in cultured cells. Depletion of CLPABP disturbed the normal subcellular localization of HuR to stress granules, and overexpression of CLPABP induced instability of leptin mRNA by inhibiting HuR function. Consequently, leptin levels in old male mice might be regulated by CLPABP expression, which might lead to body weight control. (C) 2016 Elsevier B.V. All rights reserved.
C1 [Nishino, Tasuku; Matsunaga, Ryota; Uchida, Moe; Maeda, Akane; Inagaki-Ohara, Kyoko; Konishi, Hiroaki] Prefectural Univ Hiroshima, Fac Life & Environm Sci, 562 Nanatsuka, Shobara, Hiroshima 7270023, Japan.
   [Jikihara, Hiroshi; Qi, Guangying; Shimamoto, Fumio] Prefectural Univ Hiroshima, Dept Hlth Sci, Hiroshima 7348558, Japan.
   [Kiyonari, Hiroshi] RIKEN Ctr Life Sci Technol, Anim Resource Dev Unit, Chuou Ku, 2-2-3 Minatojima Minami Machi, Kobe, Hyogo 6500047, Japan.
   [Abe, Takaya; Kiyonari, Hiroshi] RIKEN Ctr Life Sci Technol, Genet Engn Team, Chuou Ku, 2-2-3 Minatojima Minami Machi, Kobe, Hyogo 6500047, Japan.
   [Tashiro, Satoshi] Hiroshima Univ, Res Inst Radiat Biol & Med, Dept Cellular Biol, Hiroshima 7348553, Japan.
C3 RIKEN; RIKEN; Hiroshima University
RP Konishi, H (corresponding author), Prefectural Univ Hiroshima, Fac Life & Environm Sci, 562 Nanatsuka, Shobara, Hiroshima 7270023, Japan.
EM hkonishi@pu-hiroshima.ac.jp
RI Kiyonari, Hiroshi/N-7936-2015; Tashiro, Satoshi/G-4628-2019
FU JSPS KAKENHI [26440060]; Knowledge Cluster Initiative from the Ministry
   of Education, Culture, Sports, Science, and Technology, Japan;
   Grants-in-Aid for Scientific Research [26440060] Funding Source: KAKEN
FX This work was supported by JSPS KAKENHI (Grant-in-Aid for Scientific
   Research (C)) Grant Number 26440060 and by the Knowledge Cluster
   Initiative from the Ministry of Education, Culture, Sports, Science, and
   Technology, Japan.
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NR 50
TC 2
Z9 2
U1 0
U2 4
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1388-1981
EI 0006-3002
J9 BBA-MOL CELL BIOL L
JI Biochim. Biophys. Acta Mol. Cell Biol. Lipids
PD NOV
PY 2016
VL 1861
IS 11
BP 1816
EP 1827
DI 10.1016/j.bbalip.2016.09.006
PG 12
WC Biochemistry & Molecular Biology; Biophysics; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Cell Biology
GA DY7RA
UT WOS:000385325800023
PM 27616329
DA 2025-06-11
ER

PT J
AU Edlow, AG
   Hui, L
   Wick, HC
   Fried, I
   Bianchi, D
AF Edlow, A. G.
   Hui, L.
   Wick, H. C.
   Fried, I.
   Bianchi, D. W.
TI Assessing the fetal effects of maternal obesity via transcriptomic
   analysis of cord blood: a prospective case-control study
SO BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
LA English
DT Article
DE Brain; cord blood; fetal; fetal programming; maternal obesity;
   metabolic; transcriptome
ID HIGH-FAT DIET; GENE-EXPRESSION ANALYSIS; BODY-MASS INDEX; METABOLIC
   SYNDROME; AMNIOTIC-FLUID; NEURODEVELOPMENTAL OUTCOMES;
   CELLULAR-DEVELOPMENT; US ADULTS; IN-UTERO; PREGNANCY
AB ObjectiveTo analyse fetal gene expression at term using umbilical cord blood, in order to provide insights into the effects of maternal obesity on human development.
   DesignProspective case-control study.
   SettingAcademic tertiary care centre.
   PopulationEight obese (body mass index 30kg/m(2)) and eight lean (body mass index <25kg/m(2)) pregnant women undergoing prelabour caesarean delivery at term.
   MethodsWomen were matched for gestational age and fetal sex. Cord blood RNA was extracted and hybridised to gene expression arrays. Differentially regulated genes were identified using paired t-tests and the Benjamini-Hochberg correction. Functional analyses were performed using Ingenuity Pathway Analysis, BioGPS and Gene Set Enrichment Analysis with a fetal-specific annotation. Z-scores 2.0 or P-values <0.01 were considered significant.
   Main outcome measureFunctions of differentially regulated genes in fetuses of obese women.
   ResultsA total of 701 differentially regulated genes were identified, producing an expression profile implicating neurodegeneration, decreased survival of sensory neurons, and decreased neurogenesis in the fetuses of obese women. Upstream regulators related to inflammatory signalling were significantly activated; those related to insulin receptor signalling, lipid homeostasis, regulation of axonal guidance, andcellular response to oxidative stress were significantly inhibited. Of 26 tissue-specific genes that were differentially regulated in fetuses of obese women, six mapped to the fetal brain.
   ConclusionMaternal obesity affects fetal gene expression at term, implicating dysregulated brain development, inflammatory and immune signalling, glucose and lipid homeostasis, and oxidative stress. This may have implications for postnatal neurodevelopment and metabolism.
   Tweetable abstractFetal cord blood transcriptome in obese women suggests neurodevelopmental and metabolic programming effects.
   Tweetable abstract Fetal cord blood transcriptome in obese women suggests neurodevelopmental and metabolic programming effects.
C1 [Edlow, A. G.; Hui, L.; Bianchi, D. W.] Tufts Med Ctr, Mother Infant Res Inst, Boston, MA USA.
   [Edlow, A. G.; Hui, L.; Bianchi, D. W.] Tufts Med Ctr, Dept Obstet & Gynecol, Boston, MA USA.
   [Hui, L.] Mercy Hosp Women, Dept Perinatal Med, Heidelberg, Vic, Australia.
   [Wick, H. C.; Fried, I.] Tufts Univ, Dept Comp Sci, Medford, MA 02155 USA.
C3 Tufts Medical Center; Tufts Medical Center; Tufts University
RP Edlow, AG (corresponding author), Mother Infant Res Inst, 800 Washington St,Box 394, Boston, MA 02111 USA.
EM aedlow@tuftsmedicalcenter.org
RI Hui, Lisa/H-7109-2019
OI Hui, Lisa/0000-0002-9720-3562; Edlow, Andrea/0000-0003-2915-5949
FU NICHD NIH HHS [R01HD42053-10, K12 HD000849, R01 HD042053] Funding
   Source: Medline
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NR 59
TC 31
Z9 32
U1 0
U2 10
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1470-0328
EI 1471-0528
J9 BJOG-INT J OBSTET GY
JI BJOG
PD JAN
PY 2016
VL 123
IS 2
BP 180
EP 189
DI 10.1111/1471-0528.13795
PG 10
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA DA0GD
UT WOS:000367474700008
PM 26840378
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Duron, E
   Vidal, JS
   Funalot, B
   Brunel, N
   Viollet, C
   Seux, ML
   Treluyer, JM
   Epelbaum, J
   Le Bouc, Y
   Hanon, O
AF Duron, Emmanuelle
   Vidal, Jean-Sebastien
   Funalot, Benoit
   Brunel, Nadege
   Viollet, Cecile
   Seux, Marie-Laure
   Treluyer, Jean-Marc
   Epelbaum, Jacques
   Le Bouc, Yves
   Hanon, Olivier
TI Insulin-Like Growth Factor I, Insulin-like Growth factor Binding Protein
   3, and Atrial Fibrillation in the Elderly
SO JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL
   SCIENCES
LA English
DT Article
DE Elderly participants; Atrial fibrillation; Insulin-like growth factor-I;
   Insulin-like growth factor binding protein-3
ID LEFT-VENTRICULAR HYPERTROPHY; ATHEROSCLEROSIS RISK; METABOLIC SYNDROME;
   OXIDATIVE STRESS; FACTOR (IGF)-I; HEART-DISEASE; LIFE-SPAN; MANAGEMENT;
   HORMONE; IGF-1
AB Insulin-like growth factor I (IGF-I) and insulin-like growth factor binding protein 3 (IGFBP-3) are involved in oxidative stress and atherosclerosis; however, the relationship between the IGF-I system and atrial fibrillation (AF) is not known. The objective of this analysis was to assess, the relationship between IGF-I and IGFBP-3 serum levels and AF among elderly participants.
   In this cross-sectional study, 719 participants (mean age [SD] years: 78.2 [6.8]; 31.8% men) were evaluated during an outpatient geriatric assessment. AF was determined by electrocardiogram or medical record. Participants were classified into two groups: Participants with AF (n = 91) or without AF (n = 628). IGF-I and IGFBP-3 serum levels were determined by enzyme linked immunosorbent assay.
   After adjusting for age and sex, the mean IGF-I and IGFBP-3 serum levels were significantly lower among AF participants than among non-AF participants (mean IGF-I ng/mL [SD] = 133.8 [66.6] vs 157.9 [80.0], p = .02; mean IGFBP-3ng/mL [SD] = 3,653 [1,393] vs 4,151 [1,583], p = .03, respectively). After adjusting for confounding factors (age, gender, beta blocker medication, heart rate, hypertension, stroke, and chronic heart failure), low IGF-I serum level (OR [95% CI] = 0.66 [0.49-0.87]) and low IGFBP-3 serum level (0.71 [0.54-0.93]) remained independent determinants of AF.
   Low IGF-I and low IGFBP-3 serum levels were independently associated with AF in this elderly population. This result should be confirmed in a longitudinal study to evaluate whether IGF-I and/or IGFBP-3 serum levels are predictive of incident AF.
C1 [Duron, Emmanuelle; Vidal, Jean-Sebastien; Seux, Marie-Laure; Hanon, Olivier] Broca Hosp, AP HP, Dept Geriatr, F-75013 Paris, France.
   [Duron, Emmanuelle; Vidal, Jean-Sebastien; Seux, Marie-Laure; Treluyer, Jean-Marc; Hanon, Olivier] Univ Paris 05, Sorbonne Paris Cite, EA 4468, Paris, France.
   [Duron, Emmanuelle; Funalot, Benoit; Viollet, Cecile; Epelbaum, Jacques] INSERM, Ctr Psychiat & Neurosci, UMR S894, Paris, France.
   [Brunel, Nadege; Le Bouc, Yves] INSERM, UMRS 938, Ctr Rech St Antoine, Paris, France.
   [Treluyer, Jean-Marc] Hop Hotel Dieu, Unite Epidemiol & Biostat, Paris, France.
C3 Assistance Publique Hopitaux Paris (APHP); Universite Paris Cite;
   Hopital Universitaire Broca - APHP; Universite Paris Cite; Institut
   National de la Sante et de la Recherche Medicale (Inserm); Universite
   Paris Cite; Institut National de la Sante et de la Recherche Medicale
   (Inserm); Sorbonne Universite; Assistance Publique Hopitaux Paris
   (APHP); Universite Paris Cite; Hopital Universitaire Hotel-Dieu - APHP
RP Duron, E (corresponding author), Broca Hosp, AP HP, Dept Geriatr, 54 Rue Pascal, F-75013 Paris, France.
EM emmanuelle.duron@brc.aphp.fr
RI Hanon, Olivier/GWR-0220-2022; Vidal, Jean-Sebastien/D-1941-2016;
   Epelbaum, Jacques/B-2263-2013; treluyer, Jean-Marc/F-8036-2010;
   TRELUYER, Jean-Marc/GPW-8057-2022; Viollet, Cecile/I-5171-2015
OI LE BOUC, Yves/0000-0002-1017-5002; Vidal,
   Jean-Sebastien/0000-0001-6770-0720; TRELUYER,
   Jean-Marc/0000-0002-2045-4742; Hanon, Olivier/0000-0002-4697-122X;
   Funalot, Benoit/0000-0001-6352-6518; duron,
   emmanuelle/0000-0001-6680-3613; Viollet, Cecile/0000-0003-1302-2404;
   BRUNEL, Nadege/0000-0001-8433-3811
FU French Ministry of Health (PHRCN) SIGAL (Systeme IGF-I and Alzheimer's
   Disease) and Inserm
FX This study was supported by a grant from the French Ministry of Health
   (PHRCN 2006) SIGAL (Systeme IGF-I and Alzheimer's Disease) and Inserm,
   and, in part, by a gift from the France-Alzheimer Yvelines to the Centre
   de psychiatrie et neuroscience.
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NR 44
TC 16
Z9 16
U1 0
U2 17
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1079-5006
EI 1758-535X
J9 J GERONTOL A-BIOL
JI J. Gerontol. Ser. A-Biol. Sci. Med. Sci.
PD AUG
PY 2014
VL 69
IS 8
BP 1025
EP 1032
DI 10.1093/gerona/glt206
PG 8
WC Geriatrics & Gerontology; Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA AM2GS
UT WOS:000339668700014
PM 24368776
OA Bronze
DA 2025-06-11
ER

PT J
AU Niu, TH
   Jiang, M
   Xin, YN
   Jiang, XJ
   Lin, ZH
   Xuan, SY
AF Niu, Tong-Hong
   Jiang, Man
   Xin, Yong-Ning
   Jiang, Xiang-Jun
   Lin, Zhong-Hua
   Xuan, Shi-Ying
TI Lack of association between apolipoprotein C3 gene polymorphisms and
   risk of nonalcoholic fatty liver disease in a Chinese Han population vs
SO WORLD JOURNAL OF GASTROENTEROLOGY
LA English
DT Article
DE Polymorphism; Single nucleotide; Nonalcoholic fatty liver disease;
   Apolipoprotein C3; Insulin resistance; Oxidative stress
ID HEPATIC INSULIN-RESISTANCE; CORONARY-HEART-DISEASE; METABOLIC SYNDROME;
   ALANINE AMINOTRANSFERASE; REGION POLYMORPHISMS; LIPID PROFILE;
   HYPERTRIGLYCERIDEMIA; STEATOSIS; PNPLA3; PREVALENCE
AB AIM: To investigate the association between two polymorphisms of apolipoprotein C3 (APOC3) and risk of nonalcoholic fatty liver disease (NAFLD) in a Chinese Han population.
   METHODS: Genotypes for rs2854116 and rs2854117 in APOC3 and the known rs738409 in patatin-like phospholipase domain-containing protein 3 (PNPLA3) in 390 patients with NAFLD and 409 control subjects were determined by sequencing and polymerase chain reaction analysis. Serum lipid profiles were determined using biochemical methods, and an index of insulin resistance (IR, HOMA-IR), serum APOC3 concentrations and total antioxidant status (TAS) were also assessed.
   RESULTS: No significant differences in genotype and allele frequencies of rs2854116 and rs2854117 were found between the NAFLD population and the controls (P > 0.05). The OR for the association between -455C and -482T allele carriers and the risk of NAFLD were 1.06 (95%CI: 0.72-1.57, P > 0.05) and 1.00 (95%CI: 0.68-1.48, P > 0.05), respectively. The variant carriers did not have a significantly increased risk of NAFLD or elevated clinical and biochemical parameters such as APOC3 concentrations, IR (1.42 +/- 0.43 vs 1.48 +/- 0.52, P > 0.05), liver enzymes and TAS (13.94 +/- 2.01 vs 14.38 +/- 1.92, P > 0.05) compared with the controls. Moreover, the results were similar when testing was carried out independent of the genetic variation in PNPLA3.
   CONCLUSION: The two polymorphisms of the APOC3 gene are not associated with a risk of NAFLD, or with lipid profiles, IR and oxidative stress in the Chinese Han population. (C) 2014 Baishideng Publishing Group Co., Limited. All rights reserved.
C1 [Niu, Tong-Hong; Jiang, Man] Qingdao Univ, Coll Med, Qingdao 266021, Shandong, Peoples R China.
   [Niu, Tong-Hong; Jiang, Man; Xin, Yong-Ning; Jiang, Xiang-Jun; Lin, Zhong-Hua; Xuan, Shi-Ying] Qingdao Municipal Hosp, Dept Gastroenterol, Qingdao 266071, Shandong, Peoples R China.
C3 Qingdao University; Qingdao Municipal Hospital
RP Xuan, SY (corresponding author), Qingdao Municipal Hosp, Dept Gastroenterol, Qingdao 266071, Shandong, Peoples R China.
EM xsy_emuch@126.com
RI dong, quanjiang/AAD-3581-2019
FU National Natural Science Foundation of China [81170337/H0304]
FX Supported by National Natural Science Foundation of China, No.
   81170337/H0304
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NR 43
TC 30
Z9 31
U1 0
U2 18
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 8226 REGENCY DR, PLEASANTON, CA 94588 USA
SN 1007-9327
EI 2219-2840
J9 WORLD J GASTROENTERO
JI World J. Gastroenterol.
PD APR 7
PY 2014
VL 20
IS 13
BP 3655
EP 3662
DI 10.3748/wjg.v20.i13.3655
PG 8
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA AF0SC
UT WOS:000334423300030
PM 24707151
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Chen, WH
   Cao, B
   Yan, JF
AF Chen Weihong
   Cao Bin
   Yan Jianfeng
TI Transmembrane protein 126B protects against high fat diet (HFD)-induced
   renal injury by suppressing dyslipidemia via inhibition of ROS
SO BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
LA English
DT Article
DE Chronic kidney disease (CKD); Tmem126b; Apoptosis; Inflammation; ROS and
   Nrf-2
ID NF-KAPPA-B; OXIDATIVE STRESS; COMPLEX-I; MITOCHONDRIAL-COMPLEX;
   KIDNEY-DISEASE; LIPID-ACCUMULATION; INSULIN-RESISTANCE; DYSFUNCTION;
   INFLAMMATION; OBESITY
AB High fat diet (HFD)-induced metabolic syndrome followed by chronic kidney disease (CKD) have received extensive attention. However, the pathogenesis that contributes to HFD-induced renal injury still remains unclear. Transmembrane protein 126B (Tmem126b) is a complex I assembly factor, playing critical role in controlling important biological processes. In the study, we showed that Tmem126b levels were increased in kidney of HFD-fed mice. Tmem126b knockout (KO) attenuated metabolic disorders in mice challenged with HFD. Further, Tmem126b-KO mice showed alleviated kidney damage in response to HFD treatment. Mechanistically, we suggested that in kidney of mice, the dyslipidemia, apoptosis, and mitochondria dysfunction generated by HFD were prevented by Tmem126b deletion via regulating the expression of associated signals. Further, we demonstrated that HFD-induced renal inflammation was ameliorated by Tmem126b knockout, as evidenced by the down-regulated expression of inflammatory factors, including tumor necrosis factor a (TNF-alpha), interleukin (IL)-6, IL-1 beta and monocyte chemotactic protein (MCP)-1, which was through repressing nuclear factor kappa B (NF-kappa B) signaling pathways. Additionally, Tmem126b ablation repressed oxidative stress in renal samples of HFD-fed mice partly by promoting nuclear factor-erythroid 2 related factor-2 (Nrf-2) and heme oxygenase-1 (HO-1) expression. The role of Tmem126b knockout in protecting against HFD-triggered renal injury was verified in palmitate (PA)-incubated cells with Tmem126b knockdown. Importantly, inhibiting Nrf-2 expression abolished Tmem126b knockdown-alleviated lipid deposition, apoptosis, inflammation, ROS generation and mitochondrial dysfunction. Collectively, our study identified Tmem126b as a positive regulator for the progression of CKD induced by HFD through meditating Nrf-2 expression. (C) 2018 Published by Elsevier Inc.
C1 [Chen Weihong; Cao Bin; Yan Jianfeng] Ankang City Chinese Med Hosp, Dept Nephrol, Ankang 725000, Peoples R China.
RP Yan, JF (corresponding author), Ankang City Chinese Med Hosp, Dept Nephrol, Ankang 725000, Peoples R China.
EM yanjf8866@foxmail.com
RI Yan, Jianfeng/G-9099-2016
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NR 39
TC 16
Z9 17
U1 0
U2 15
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0006-291X
EI 1090-2104
J9 BIOCHEM BIOPH RES CO
JI Biochem. Biophys. Res. Commun.
PD JAN 29
PY 2019
VL 509
IS 1
BP 40
EP 47
DI 10.1016/j.bbrc.2018.12.003
PG 8
WC Biochemistry & Molecular Biology; Biophysics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics
GA HI5KV
UT WOS:000456491800006
PM 30580996
DA 2025-06-11
ER

PT J
AU Aragno, M
   Mastrocola, R
AF Aragno, Manuela
   Mastrocola, Raffaella
TI Dietary Sugars and Endogenous Formation of Advanced Glycation
   Endproducts: Emerging Mechanisms of Disease
SO NUTRIENTS
LA English
DT Review
DE advanced glycation end products; fructose; glucose; lipogenesis;
   sphingolipids; NLRP3; Nrf2; mitochondrial dysfunction; oxidative stress
ID BOVINE SERUM-ALBUMIN; FRUCTOSE CORN SYRUP; END-PRODUCTS AGES; SWEETENED
   SOFT DRINKS; INSULIN-RESISTANCE; NLRP3 INFLAMMASOME; LIPID-ACCUMULATION;
   METABOLIC SYNDROME; OXIDATIVE STRESS; ADIPOSE-TISSUE
AB The rapid increase in metabolic diseases, which occurred in the last three decades in both industrialized and developing countries, has been related to the rise in sugar-added foods and sweetened beverages consumption. An emerging topic in the pathogenesis of metabolic diseases related to modern nutrition is the role of Advanced Glycation Endproducts (AGEs). AGEs can be ingested with high temperature processed foods, but also endogenously formed as a consequence of a high dietary sugar intake. Animal models of high sugar consumption, in particular fructose, have reported AGE accumulation in different tissues in association with peripheral insulin resistance and lipid metabolism alterations. The in vitro observation that fructose is one of the most rapid and effective glycating agents when compared to other sugars has prompted the investigation of the in vivo fructose-induced glycation. In particular, the widespread employment of fructose as sweetener has been ascribed by many experimental and observational studies for the enhancement of lipogenesis and intracellular lipid deposition. Indeed, diet-derived AGEs have been demonstrated to interfere with many cell functions such as lipid synthesis, inflammation, antioxidant defences, and mitochondrial metabolism. Moreover, emerging evidence also in humans suggest that this impact of dietary AGEs on different signalling pathways can contribute to the onset of organ damage in liver, skeletal and cardiac muscle, and the brain, affecting not only metabolic control, but global health. Indeed, the most recent reports on the effects of high sugar consumption and diet-derived AGEs on human health reviewed here suggest the need to limit the dietary sources of AGEs, including added sugars, to prevent the development of metabolic diseases and related comorbidities.
C1 [Aragno, Manuela; Mastrocola, Raffaella] Univ Turin, Dept Clin & Biol Sci, Corso Raffaello 30, I-10125 Turin, Italy.
C3 University of Turin
RP Mastrocola, R (corresponding author), Univ Turin, Dept Clin & Biol Sci, Corso Raffaello 30, I-10125 Turin, Italy.
EM manuela.aragno@unito.it; raffaella.mastrocola@unito.it
OI ARAGNO, Manuela/0000-0002-0453-5235; Mastrocola,
   Raffaella/0000-0002-0104-6129
FU University of Turin
FX This work was supported and funded by the University of Turin (Ricerca
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NR 113
TC 174
Z9 189
U1 5
U2 146
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD APR
PY 2017
VL 9
IS 4
AR 385
DI 10.3390/nu9040385
PG 16
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA EU9JI
UT WOS:000401355600070
PM 28420091
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Chang, PF
   Lin, YC
   Liu, K
   Yeh, SJ
   Ni, YH
AF Chang, P-F
   Lin, Y-C
   Liu, K.
   Yeh, S-J
   Ni, Y-H
TI Heme oxygenase-1 gene promoter polymorphism and the risk of pediatric
   nonalcoholic fatty liver disease
SO INTERNATIONAL JOURNAL OF OBESITY
LA English
DT Article
ID CORONARY-ARTERY DISEASE; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   MICROSATELLITE POLYMORPHISM; HEPATIC STEATOSIS; CARBON-MONOXIDE;
   STEATOHEPATITIS; SUSCEPTIBILITY; OBESITY; ASSOCIATION
AB BACKGROUND AND OBJECTIVES: Oxidative stress and the insulin-resistant state are thought to be key components in the pathogenesis of pediatric nonalcoholic fatty liver disease (NAFLD). Heme oxygenase (HO) is important in the defense against oxidative stress. This study aimed to assess the association of HO-1 gene promoter polymorphism and insulin resistance with NAFLD among obese children.
   METHODS: A total of 101 obese children aged 6-17 years were recruited. Anthropometric, serum biochemical variables and biomarkers for glucose and insulin metabolism were measured. We screened the allelic frequencies of (GT)(n) repeats in the HO-1 gene promoter among these obese children. NAFLD was determined through liver ultrasonography. Because the distribution of numbers of (GT) n repeats was bimodal, we divided the alleles into two classes: class S included shorter (27) repeats, and class L included longer (>= 27) repeats. We assessed the effects of the length of (GT) n repeats in HO-1 gene promoter on pediatric NAFLD.
   RESULTS: Of the 101 obese subjects, 27 (26.7%) had NAFLD. The alanine aminotransferase level was higher in patients carrying L alleles (L/L and L/S) than patients with S alleles (S/S) (46.2 +/- 49.3 IU l(-1) versus 30.2 +/- 20.1 IU l(-1); P = 0.027). The significant risk factors for pediatric NAFLD were patients carrying L alleles (L/L and L/S) (odds ratio (OR) = 18.84; 95% confidence interval (CI): 1.45-245.22; P = 0.025), homeostasis model assessment of insulin resistance (OR = 1.40; 95% CI: 1.07-1.83; P = 0.014) and age (OR = 1.24; 95% CI: 1.03-1.50; P = 0.025).
   CONCLUSION: In this hospital-based study, the obese children with longer GT repeats in the HO-1 gene promoter and insulin resistance were susceptible to NAFLD.
C1 [Chang, P-F; Lin, Y-C; Liu, K.; Yeh, S-J] Far Eastern Mem Hosp, Dept Pediat, Pan Chiao, New Taipei, Taiwan.
   [Chang, P-F; Lin, Y-C; Yeh, S-J] Oriental Inst Technol, Dept Healthcare Adm, Pan Chiao, New Taipei, Taiwan.
   [Ni, Y-H] Natl Taiwan Univ Hosp, Dept Pediat, Taipei 100, Taiwan.
C3 Far Eastern Memorial Hospital; Asia Eastern University of Science &
   Technology; National Taiwan University; National Taiwan University
   Hospital
RP Ni, YH (corresponding author), Natl Taiwan Univ Hosp, Dept Pediat, 8 Chung Shan South Rd, Taipei 100, Taiwan.
EM yhni@ntu.edu.tw
OI Ni, Yen-Hsuan/0000-0002-1158-5249
FU Far Eastern Memorial Hospital [FEMH- 2011- C - 30, FEMH- 2012- C- 040]
FX We are indebted to Jyh-Feng Lu for laboratory work, and to Chien-Hao
   Chen for assistance with the statistical analysis. This work was
   supported by research grants from the Far Eastern Memorial Hospital
   (FEMH- 2011- C - 30 and FEMH- 2012- C- 040).
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NR 39
TC 16
Z9 17
U1 0
U2 3
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0307-0565
EI 1476-5497
J9 INT J OBESITY
JI Int. J. Obes.
PD AUG
PY 2015
VL 39
IS 8
BP 1236
EP 1240
DI 10.1038/ijo.2015.46
PG 5
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA CR0BK
UT WOS:000360983000009
PM 25835554
OA Bronze
DA 2025-06-11
ER

PT J
AU Cho, HS
   Lee, SW
   Kim, ES
   Mo, EY
   Shin, JY
   Moon, SD
   Han, JH
AF Cho, H. S.
   Lee, S. W.
   Kim, E. S.
   Mo, E. Y.
   Shin, J. Y.
   Moon, S. D.
   Han, J. H.
TI Clinical significance of serum bilirubin and gamma-glutamyltransferase
   levels on coronary atherosclerosis assessed by multidetector computed
   tomography
SO NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
LA English
DT Article
DE Bilirubin; Gamma-glutamyltransferase; Atherosclerosis; Coronary artery
   calcification score; Coronary artery stenosis
ID CARDIOVASCULAR-DISEASE; ARTERY CALCIFICATION; OXIDATIVE STRESS;
   METABOLIC SYNDROME; HEART-DISEASE; RISK; ASSOCIATION; ANGIOGRAPHY;
   MORTALITY; MARKER
AB Background and aims: Low bilirubin and high gamma-glutamyltransferase (GGT), which are endogenous markers of oxidative stress, confer a higher risk of cardiovascular disease (CVD). We investigated associations between serum concentrations of bilirubin, GGT and coronary atherosclerosis.
   Methods and results: A cross-sectional analysis was performed on 1520 subjects who underwent multidetector computed tomography scans. Coronary atherosclerosis was assessed by coronary artery calcium score (CACS) and obstructive coronary artery disease (OCAD), was defined as the presence of coronary artery stenosis of >= 50%. Total bilirubin (TB) level was negatively correlated with CACS and coronary stenosis whereas GGT level was positively correlated with CACS in men. However, there was no correlation between TB, GGT levels and either CACS or coronary artery stenosis in women. In a multivariate-adjusted model, TB level was inversely associated with a CACS > 100 [odds ratio (OR) per log standard deviation (SD), 0.67; 95% confidence interval (CI), 0.52-0.87], and OCAD (OR per log SD, 0.77; 95% CI, 0.62-0.95) in men. By contrast, GGT level was positively associated with a CACS > 100 (OR per log SD, 1.35; 95% CI, 1.05-1.73) but not with OCAD. Adding TB and GGT to the conventional risk factors increased predictive accuracy for CACS > 100 (net reclassification improvement index [NRI] = 13.1%, P = 0.026; integrated discrimination index [IDI] = 0.024, P = 0.001) and for OCAD (NRI = 12.6%, P = 0.026; IDI = 0.010, P = 0.013).
   Conclusions: Low TB and high GGT levels were concomitantly associated with coronary atherosclerosis in Korean men. Future studies are needed to elucidate the causal associations of TB and GGT with CVD. (C) 2015 Elsevier B.V. All rights reserved.
C1 [Cho, H. S.; Lee, S. W.; Kim, E. S.; Mo, E. Y.; Shin, J. Y.; Moon, S. D.; Han, J. H.] Catholic Univ Korea, Coll Med, Dept Internal Med, Seoul 137701, South Korea.
   [Kim, E. S.; Mo, E. Y.; Moon, S. D.; Han, J. H.] Incheon St Marys Hosp, Dept Internal Med, Div Endocrinol & Metab, Inchon, South Korea.
   [Lee, S. W.] Catholic Univ Korea, Coll Med, Dept Internal Med, Div Hepatol, Seoul 137701, South Korea.
   [Cho, H. S.; Shin, J. Y.] Catholic Univ Korea, Seoul St Marys Hosp, Hlth Promot Ctr, Coll Med, Seoul 137701, South Korea.
C3 Catholic University of Korea; Catholic University of Korea; Seoul St.
   Mary's Hospital; Catholic University of Korea
RP Kim, ES (corresponding author), Catholic Univ Korea, Incheon St Marys Hosp, Coll Med, Dept Internal Med,Div Endocrinol & Metab, 222 Banpo Daero, Seoul 137701, South Korea.
EM 13900@catholic.ac.kr
FU National Research Foundation of Korea (NRF) grant - Korea government
   (MSIP) [2014R1A1A1006144]; Korean Diabetes Association; Catholic Medical
   Center Research Foundation
FX This study was supported by the National Research Foundation of Korea
   (NRF) grant funded by the Korea government (MSIP, 2014R1A1A1006144) and
   the grant (N.H.K., 2009) from the Korean Diabetes Association, and the
   grant from the Catholic Medical Center Research Foundation made in the
   program year of 2013.
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NR 38
TC 15
Z9 15
U1 0
U2 5
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0939-4753
EI 1590-3729
J9 NUTR METAB CARDIOVAS
JI Nutr. Metab. Carbiovasc. Dis.
PD JUL
PY 2015
VL 25
IS 7
BP 677
EP 685
DI 10.1016/j.numecd.2015.03.014
PG 9
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism; Nutrition
   & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism;
   Nutrition & Dietetics
GA CK5BV
UT WOS:000356238000008
PM 26026212
DA 2025-06-11
ER

PT J
AU Cheng, SL
   Shao, JS
   Halstead, LR
   Distelhorst, K
   Sierra, O
   Towler, DA
AF Cheng, Su-Li
   Shao, Jian-Su
   Halstead, Linda R.
   Distelhorst, Kathryn
   Sierra, Oscar
   Towler, Dwight A.
TI Activation of Vascular Smooth Muscle Parathyroid Hormone Receptor
   Inhibits Wnt/β-Catenin Signaling and Aortic Fibrosis in Diabetic
   Arteriosclerosis
SO CIRCULATION RESEARCH
LA English
DT Article
DE arteriosclerosis; beta-catenin; diabetes; parathyroid hormone; Wnt
ID CHRONIC KIDNEY-DISEASE; TRANSGENIC MICE; BONE-FORMATION; BETA-CATENIN;
   ADIPOGENIC DIFFERENTIATION; ARTERY CALCIFICATION; VALVE CALCIFICATION;
   CELL PROLIFERATION; METABOLIC SYNDROME; OXIDATIVE STRESS
AB Rationale: Vascular fibrosis and calcification contribute to diabetic arteriosclerosis, impairing Windkessel physiology necessary for distal tissue perfusion. Wnt family members, upregulated in arteries by the low-grade inflammation of "diabesity," stimulate type I collagen expression and osteogenic mineralization of mesenchymal progenitors via beta-catenin. Conversely, parathyroid hormone (PTH) inhibits aortic calcification in low-density lipoprotein receptor (LDLR)-deficient mice fed high fat diabetogenic diets (HFD).
   Objective: We sought to determine the impact of vascular PTH receptor (PTH1R) activity on arteriosclerotic Wnt/beta-catenin signaling in vitro and in vivo. We generated SM-caPTH1R transgenic mice, a model in which the constitutively active PTH1R variant H223R (caPTH1R) is expressed only in the vasculature.
   Methods and Results: The caPTH1R inhibited Wnt/beta-catenin signaling, collagen production, and vascular smooth muscle cell proliferation and calcification in vitro. Transgenic SM-caPTH1R; LDLR+/- mice fed HFD develop diabesity, with no improvements in fasting serum glucose, cholesterol, weight, body composition, or bone mass versus LDLR+/- siblings. SM-caPTH1R downregulated aortic Col1A1, Runx2, and Nox1 expression without altering TNF, Msx2, Wnt7a/b, or Nox4. The SM-caPTH1R transgene decreased aortic beta-catenin protein accumulation and signaling in diabetic LDLR+/- mice. Levels of aortic superoxide (a precursor of peroxide that activates pro-matrix metalloproteinase 9 and osteogenic signaling in vascular smooth muscle cells) were suppressed by the SM-caPTH1R transgene. Aortic calcification, collagen accumulation, and wall thickness were concomitantly reduced, enhancing vessel distensibility.
   Conclusions: Cell-autonomous vascular smooth muscle cell PTH1R activity inhibits arteriosclerotic Wnt/beta-catenin signaling and reduces vascular oxidative stress, thus limiting aortic type I collagen and calcium accrual in diabetic LDLR-deficient mice. (Circ Res. 2010; 107:271-282.)
C1 [Cheng, Su-Li; Shao, Jian-Su; Halstead, Linda R.; Distelhorst, Kathryn; Sierra, Oscar; Towler, Dwight A.] Washington Univ, Dept Med, St Louis, MO 63110 USA.
C3 Washington University (WUSTL)
RP Towler, DA (corresponding author), Washington Univ, Dept Med, Campus Box 8301,660 S Euclid Ave, St Louis, MO 63110 USA.
EM dtowler@im.wustl.edu
RI Sierra, Oscar/MFH-2349-2025
OI Towler, Dwight/0000-0003-2107-7923
FU NHLBI NIH HHS [HL081138, HL069229, R01 HL088651, R01 HL069229, R01
   HL081138] Funding Source: Medline
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NR 75
TC 90
Z9 95
U1 1
U2 11
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0009-7330
EI 1524-4571
J9 CIRC RES
JI Circ.Res.
PD JUL 23
PY 2010
VL 107
IS 2
BP 271
EP U222
DI 10.1161/CIRCRESAHA.110.219899
PG 35
WC Cardiac & Cardiovascular Systems; Hematology; Peripheral Vascular
   Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Hematology
GA 629LV
UT WOS:000280201200014
PM 20489161
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Matteucci, E
   Rosada, J
   Pinelli, M
   Giusti, C
   Giampietro, O
AF Matteucci, Elena
   Rosada, Javier
   Pinelli, Massimiliano
   Giusti, Costantino
   Giampietro, Ottavio
TI Systolic blood pressure response to exercise in type 1 diabetes families
   compared with healthy control individuals
SO JOURNAL OF HYPERTENSION
LA English
DT Article
DE blood pressure; cardiovascular risk; exercise testing; families; type 1
   diabetes
ID CARDIOVASCULAR-DISEASE RISK; INSULIN-RESISTANCE; OXIDATIVE STRESS;
   PHYSICAL-ACTIVITY; IDDM PATIENTS; NEPHROPATHY; HYPERTENSION; PLASMA;
   PREDISPOSITION; ASSOCIATION
AB Objective Oxidative stress is increased in type 1 diabetes families. Since oxidative damage is a mediator of vascular injury and familial predisposition to hypertension increases the risk of hypertension and diabetic nephropathy, we studied blood pressure responses to exercise and cardiovascular risk factors in type 1 diabetes families.
   Methods Thirty-five type 1 patients, 74 first-degree relatives, and 95 healthy individuals without established coronary heart disease underwent a cycle ergometer test. Examination included medical history, lifestyle questionnaire, body weight, blood pressure, and laboratory tests [fasting plasma glucose and insulin, haemoglobin A(1c) (HbA(1c)), plasma lipids, C-reactive protein, fibrinogen, folate, plasma thiols, and albumin excretion rate].
   Results Diabetic patients had higher plasma glucose, HbA(1c), folate, and albuminuria, while lower plasma thiols than controls; relatives differed from controls in higher plasma total cholesterol and albuminuria, lower plasma thiols. No patient presented exercised-induced angina. Diabetic patients achieved a higher maximal exercise systolic blood pressure (similar workload); systolic pressure remained high during recovery. Relatives showed higher values of systolic pressure at peak exercise (same workload). The following were associated with an abnormal blood pressure response to exercise: diastolic blood pressure and HbA(1c) in the control sample; disease duration and fibrinogen in the diabetic group; plasma low-density lipoprotein (LDL) cholesterol, body mass index (BMI), housework, and plasma thiols among relatives.
   Conclusion An abnormal blood pressure response to exercise testing has been identified for the first time in asymptomatic normotensive non-diabetic relatives of type 1 diabetics, which was associated with indices of metabolic syndrome and oxidative damage. Moreover, in healthy normotensive non-diabetic control individuals (without a family history of type 1 diabetes), the systolic blood pressure response to exercise was significantly correlated with HbA(1c) levels.
C1 Univ Pisa, Dept Internal Med, I-56126 Pisa, Italy.
C3 University of Pisa
RP Matteucci, E (corresponding author), Univ Pisa, Dept Internal Med, Via Roma 67, I-56126 Pisa, Italy.
EM ematteuc@int.med.unipi.it
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NR 37
TC 22
Z9 22
U1 0
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0263-6352
EI 1473-5598
J9 J HYPERTENS
JI J. Hypertens.
PD SEP
PY 2006
VL 24
IS 9
BP 1745
EP 1751
DI 10.1097/01.hjh.0000242398.60838.5d
PG 7
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 084DG
UT WOS:000240511500012
PM 16915023
DA 2025-06-11
ER

PT J
AU McGowan, TA
   Dunn, SR
   Falkner, B
   Sharma, K
AF McGowan, Tracy A.
   Dunn, Stephen R.
   Falkner, Bonita
   Sharma, Kumar
TI Stimulation of urinary TGF-β and isoprostanes in response to
   hyperglycemia in humans
SO CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
LA English
DT Article; Proceedings Paper
CT 34th Annual Meeting of the American-Society-of-Nephrology
CY OCT 10-17, 2001
CL SAN FRANCISCO, CA
SP Amer Soc Nephrol
ID GROWTH-FACTOR-BETA; DIABETIC KIDNEY-DISEASE; MATRIX GENE-EXPRESSION;
   HIGH GLUCOSE; MESANGIAL CELLS; ANGIOTENSIN-II; EXTRACELLULAR-MATRIX;
   TRANSFORMING GROWTH-FACTOR-BETA-1; METABOLIC SYNDROME; OXIDATIVE STRESS
AB TGF-beta and oxidant stress have been considered to play key roles in the pathogenesis of diabetic vascular complications; however, the stimulus for these factors in humans is not clear. The purpose of this in vivo study was to determine whether transient hyperglycemia in humans is sufficient to increase renal production of TGF-beta 1 and urinary isoprostanes in normal humans. A hyperglycemic clamp procedure was performed on 13 healthy volunteers. An infusion of glucose was delivered to maintain the plasma glucose between 200 and 250 mg/dl for 120 min. Timed urine samples, collected on an overnight period before the study, at each void on completion of the procedure, and the following overnight, were assayed for TGF-beta 1, F2-isoprostanes, and creatinine. Plasma samples were assayed for TGF-beta 1 before and at timed intervals throughout hyperglycemia. Mean baseline TGF-beta 1 in plasma was 4.57 +/- 0.22 ng/ml, and no change in plasma TGF-beta 1 levels was detected throughout the hyperglycemia period. Baseline urine TGF-beta 1 was 4.14 +/- 1.16 pg/mg creatinine. The fractional urine samples showed a sharp increase in TGF-beta 1 excretion in the 12-h period after exposure to hyperglycemia, with a mean peak TGF-beta 1 of 30.43 +/- 8.05 pg/mg (P = 0.002). TGF-beta 1 excretion in the subsequent overnight urine sample was not different from baseline (4.62 +/- 1.21 pg/mg). Urinary isoprostanes increased from a baseline of 4.92 +/- 0.74 to 13.8 +/- 3.37 ng/mg creatinine. It is concluded that 120 min of hyperglycemia in normal humans is sufficient to induce an increase in renal TGF-beta 1 and isoprostane production.
C1 Thomas Jefferson Univ, Dept Med, Div Nephrol, Ctr Diabet Kidney Dis, Philadelphia, PA 19107 USA.
   Thomas Jefferson Univ, Dept Med, Div Nephrol, Cell & Mol Biol Kidney Dis Dorrance Hamilton Res, Philadelphia, PA 19107 USA.
   Thomas Jefferson Univ, Dept Med, Div Nephrol, Ctr Hypertens, Philadelphia, PA 19107 USA.
C3 Thomas Jefferson University; Thomas Jefferson University; Thomas
   Jefferson University
RP Sharma, K (corresponding author), Thomas Jefferson Univ, Dept Med, Div Nephrol, Ctr Diabet Kidney Dis, 353 Jefferson Alumni Hall,1020 Locust St, Philadelphia, PA 19107 USA.
EM kumar.sharma@jefferson.edu
RI Falkner, Bonita/Y-8451-2019
FU NHLBI NIH HHS [HL51547] Funding Source: Medline; NIDDK NIH HHS [DK63017,
   DK046107] Funding Source: Medline
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NR 38
TC 33
Z9 36
U1 0
U2 0
PU AMER SOC NEPHROLOGY
PI WASHINGTON
PA 1725 I ST, NW STE 510, WASHINGTON, DC 20006 USA
SN 1555-9041
EI 1555-905X
J9 CLIN J AM SOC NEPHRO
JI Clin. J. Am. Soc. Nephrol.
PD MAR
PY 2006
VL 1
IS 2
BP 263
EP 268
DI 10.2215/CJN.00990905
PG 6
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Urology & Nephrology
GA 107LH
UT WOS:000242172600012
PM 17699215
OA Bronze
DA 2025-06-11
ER

PT J
AU Wypych, A
   Dunislawska, A
   Grabowska, M
   Michalek, K
   Ozgo, M
   Liput, K
   Herosimczyk, A
   Polawska, E
   Pierzchala, M
   Lepczynski, A
AF Wypych, A.
   Dunislawska, A.
   Grabowska, M.
   Michalek, K.
   Ozgo, M.
   Liput, K.
   Herosimczyk, A.
   Polawska, E.
   Pierzchala, M.
   Lepczynski, A.
TI Effects of three-month feeding high-fat diets with different fatty acid
   composition on kidney histology and expression of genes related to
   cellular stress and water-electrolyte homeostasis in mice
SO JOURNAL OF ANIMAL AND FEED SCIENCES
LA English
DT Article
DE alpha-linolenic acid; kidney; linoleic acid; obesity; PUFA
ID OXIDATIVE STRESS; DOCOSAHEXAENOIC ACID; METABOLIC SYNDROME; RENAL
   INJURY; OBESITY; SUPPLEMENTATION; EPOXIDE; DISEASE; AQP2
AB The Western diet, which is typically high in saturated fatty acids (SFAs) and low in n-3 polyunsaturated fatty acids (PUFAs), has been identified as a factor contributing to the growing obesity rate. Long-term consumption of high-fat diets (HFDs) has also been associated with increased risk of chronic kidney disease. Therefore, we hypothesized that different fatty acids composition in HFDs would differentially affect renal microstructure and expression pattern of selected genes. Swiss-Webster male mice (n = 24) were fed a standard chow for mice (STD) or HFDs rich in SFAs, and rich in PUFA with a linoleic acid (LA) to alpha-linolenic acid (ALA) ratio of 14:1 (HR) or 5:1 (LR) for 3 months. We observed that both the SFA and HR groups had increased epithelial cell vacuolisation, collagenous tissue area and number of TUNEL-positive cells, accompanied by elevated Kim-1 expression in the kidneys. Sod1 and Cat were up-regulated, while Cox2 was down-regulated in the kidneys of HR mice when compared to the STD group. Both PUFA-rich HFDs down-regulated the Ren1 and Agt genes. The HR diet also caused an increased deposition of AQP2 in the basolateral membrane (BLM) and intracellular space of collecting duct (CD) cells. In both the HR and SFA groups, an increased expression of the Aqp3 gene and AQP3 protein in CD cells was observed. In conclusion, the findings suggest that higher levels of ALA in the HFD were associated with a reduction in the severity of renal tissue lesions. Diets rich in SFAs or LA have the potential to modify the renal mechanism of facultative urine concentration by altering the expression and/or distribution of AQP2 and AQP3 in the kidneys.
C1 [Wypych, A.; Michalek, K.; Ozgo, M.; Herosimczyk, A.; Lepczynski, A.] West Pomeranian Univ Technol, Fac Biotechnol & Anim Husb, Dept Physiol Cytobiol & Prote, PL-71270 Szczecin, Poland.
   [Dunislawska, A.] Bydgoszcz Univ Sci & Technol, Fac Anim Breeding & Biol, Dept Anim Biotechnol & Genet, PL-85084 Bydgoszcz, Poland.
   [Grabowska, M.] Pomeranian Med Univ, Fac Hlth Sci, Dept Histol & Dev Biol, PL-71210 Szczecin, Poland.
   [Liput, K.] Polish Acad Sci, Inst Biochem & Biophys, Lab Mol Basis Aging & Rejuvenat, PL-02106 Warsaw, Poland.
   [Polawska, E.; Pierzchala, M.] Polish Acad Sci, Inst Genet & Anim Biotechnol, Dept Genom & Biodivers, PL-05552 Magdalenka, Poland.
C3 West Pomeranian University of Technology; Bydgoszcz University of
   Science & Technology; Pomeranian Medical University; Polish Academy of
   Sciences; Institute of Biochemistry & Biophysics - Polish Academy of
   Sciences; Polish Academy of Sciences
RP Wypych, A (corresponding author), West Pomeranian Univ Technol, Fac Biotechnol & Anim Husb, Dept Physiol Cytobiol & Prote, PL-71270 Szczecin, Poland.
EM agata.grzesiak@zut.edu.pl
RI Michałek, Katarzyna/H-9790-2016; Ożgo, Małgorzata/J-2770-2016;
   Grabowska, Marta/AAT-9189-2021; Pierzchala, Mariusz/G-1052-2013;
   Herosimczyk, Agnieszka/H-9788-2016; Wypych, Agata/MVX-6399-2025;
   Lepczynski, Adam/H-9806-2016
OI Michalek, Katarzyna/0000-0001-7201-328X; Ozgo,
   Malgorzata/0000-0001-5558-2173; Wypych, Agata/0000-0001-5746-1973;
   Lepczynski, Adam/0000-0002-5144-7940
FU KNOW (Leading National Research Centre) Scientific Consortium "Healthy
   Animal - Safe Food" [05-1/KNOW2/2015, KNOW2015/CB/PRO1/44]; Rector of
   the West Pomeranian University of Technology in Szczecin [35/2022]
FX This work received financial support from two sources. The dietary
   experiment was conducted with the support of KNOW (Leading National
   Research Centre) Scientific Consortium "Healthy Animal - Safe Food",
   decision of the Ministry of Science and Higher Education No.
   05-1/KNOW2/2015", grant no. KNOW2015/CB/PRO1/44. The analyses performed
   were supported by The Rector of the West Pomeranian University of
   Technology in Szczecin for PhD students of The Doctoral School, grant
   no. 35/2022.
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NR 48
TC 3
Z9 3
U1 0
U2 3
PU KIELANOWSKI INST ANIMAL PHYSIOLOGY NUTRITION
PI JABLONNA
PA UL INSTYTUCKA 3, 05-110 JABLONNA, POLAND
SN 1230-1388
J9 J ANIM FEED SCI
JI J. Anim. Feed Sci.
PY 2023
VL 32
IS 4
BP 372
EP 384
DI 10.22358/jafs/163179/2023
PG 13
WC Agriculture, Dairy & Animal Science
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture
GA CH7S3
UT WOS:001124433900007
OA gold
DA 2025-06-11
ER

PT J
AU Chen, YM
   Yu, XJ
   Liu, KL
   Gao, HL
   Li, Y
   Sun, TZ
   Shi, XL
   Li, HB
   Zhu, GQ
   Qi, J
   Kang, YM
AF Chen, Yan-Mei
   Yu, Xiao-Jing
   Liu, Kai-Li
   Gao, Hong-Li
   Li, Ying
   Sun, Tian-Ze
   Shi, Xiao-Lian
   Li, Hong-Bao
   Zhu, Guo-Qing
   Qi, Jie
   Kang, Yu-Ming
TI Inhibition of Hypothalamic Inhibitor κB Kinase β/Nuclear Transcription
   Factor κB Pathway Attenuates Metabolism and Cardiac Dysfunction in Type
   2 Diabetic Rats
SO NEUROENDOCRINOLOGY
LA English
DT Article
DE Type 2 diabetes mellitus; Hypothalamus; IKK beta/NF-kappa B pathway;
   Inflammation; Cardiac dysfunction
ID SALT-INDUCED HYPERTENSION; DIET-INDUCED OBESITY; OXIDATIVE STRESS;
   PARAVENTRICULAR NUCLEUS; MODULATING NEUROTRANSMITTERS;
   INSULIN-RESISTANCE; INFLAMMATION; RECEPTOR; ACTIVATION; EXPRESSION
AB Background:Inflammation and oxidative stress play important roles in energy imbalance and its complications. Recent research indicates that hypothalamic inflammation may contribute to the pathogenesis of metabolic syndrome and cardiac dysfunction, but the mechanisms remain unclear. We hypothesized that suppression of the proinflammatory IKK beta/NF-kappa B pathway in the hypothalamus can improve energy balance and cardiac function in type 2 diabetic (T2D) rats.Methods:Normal and T2D rats received bilateral hypothalamic arcuate nucleus (ARC) infusions of the IKK beta inhibitor SC-514 or vehicle via osmotic minipump. Metabolic phenotyping, immunohistochemical analyses, and biochemical analyses were used to investigate the outcomes of inhibition of the hypothalamic IKK beta. Echocardiography and glucometer were used for measuring cardiac function and blood glucose, respectively. Blood samples were collected for the evaluation of circulating proinflammatory cytokines. Heart was harvested for cardiac morphology evaluations. The ARC was harvested and analyzed for IKK beta, NF-kappa B, proinflammatory cytokines, reactive oxygen species (ROS), and NAD(P)H (gp91(phox), p47(phox)) oxidase activity levels and neuropeptides.Results:Compared with normal rats, T2D rats were characterized by hyperglycemia, hyperinsulinemia, glucose intolerance, cardiac dysfunction, as well as higher ARC levels of IKK beta, NF-kappa B, proinflammatory cytokines, ROS, gp91(phox), and p47(phox). ARC infusion of the IKK beta inhibitor SC-514 attenuated all these changes in T2D rats, but not in normal rats.Conclusions:Our results indicate that the hypothalamic IKK beta/NF-kappa B pathway plays a key role in modulating energy imbalance and cardiac dysfunction, suggesting its potential therapeutic role during type 2 diabetes mellitus. (c) 2019 S. Karger AG, Basel
C1 [Chen, Yan-Mei; Yu, Xiao-Jing; Liu, Kai-Li; Gao, Hong-Li; Li, Ying; Li, Hong-Bao; Qi, Jie; Kang, Yu-Ming] Xi An Jiao Tong Univ, Sch Basic Med Sci, Dept Physiol & Pathophysiol, Key Lab Environm & Genes Related Dis,Minist Educ, Xian, Peoples R China.
   [Sun, Tian-Ze] Xi An Jiao Tong Univ, Sch Basic Med Sci, Dept Human Anat & Histol & Embryol, Hlth Sci Ctr, Xian, Peoples R China.
   [Shi, Xiao-Lian] Xi An Jiao Tong Univ, Sch Basic Med Sci, Dept Pharmacol, Hlth Sci Ctr, Xian, Peoples R China.
   [Zhu, Guo-Qing] Nanjing Med Univ, Dept Physiol, Key Lab Cardiovasc Dis & Mol Intervent, Nanjing, Peoples R China.
C3 Ministry of Education - China; Xi'an Jiaotong University; Xi'an Jiaotong
   University; Xi'an Jiaotong University; Nanjing Medical University
RP Qi, J; Kang, YM (corresponding author), Xi An Jiao Tong Univ, Sch Basic Med Sci, Dept Physiol & Pathophysiol, Xian 710061, Peoples R China.
EM jie-qi@xjtu.edu.cn; ykang@mail.xjtu.edu.cn
RI Li, Hong-Bao/ACO-9139-2022
OI Zhu, Guo-Qing/0000-0002-3132-9592
FU National Natural Science Foundation of China [81770426, 81600333,
   81600330, 91639105]; Natural Science Foundation of Shaanxi [2018JQ3047,
   2019JQ-605]; China Postdoctoral Science Foundation [2016M602835,
   2016M590957]; Shaanxi Postdoctoral Science Foundation [2016BSHEDZZ91]
FX This study was supported by the National Natural Science Foundation of
   China (Nos. 81770426, 81600333, 81600330, 91639105), the Natural Science
   Foundation of Shaanxi (Nos. 2018JQ3047, 2019JQ-605), the China
   Postdoctoral Science Foundation (Nos. 2016M602835, 2016M590957), and the
   Shaanxi Postdoctoral Science Foundation (No. 2016BSHEDZZ91).
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NR 51
TC 10
Z9 11
U1 1
U2 8
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0028-3835
EI 1423-0194
J9 NEUROENDOCRINOLOGY
JI Neuroendocrinology
PD OCT
PY 2020
VL 110
IS 11-12
BP 899
EP 913
DI 10.1159/000504444
PG 15
WC Endocrinology & Metabolism; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology
GA NX9SY
UT WOS:000576042600002
PM 31671427
DA 2025-06-11
ER

PT J
AU Lai, SH
   Tsai, YW
   Chen, YC
   Chang, SS
AF Lai, Shih-Han
   Tsai, Yi-Wen
   Chen, Yi-Chuan
   Chang, Shy-Shin
TI Obesity, hyperhomocysteinaemia and risk of chronic kidney disease: a
   population-based study
SO FAMILY PRACTICE
LA English
DT Article
DE Body mass index; chronic; glomerular filtration rate; homocysteine;
   inflammation; obesity; renal insufficiency
ID BODY-MASS INDEX; INSULIN-RESISTANCE; METABOLIC SYNDROME; ADIPOSE-TISSUE;
   HOMOCYSTEINE; ADIPOKINES; PROTEIN; STRESS; LEPTIN; ADULTS
AB Background. Obesity is associated with increased risk of cardiovascular disease and chronic kidney disease (CKD). Hyperhomocysteinaemia refers to increased oxidative stress and has been associated with the risk of CKD.
   Objectives. We investigated the association among body mass index (BMI), homocysteine level and impaired renal function in a Taiwanese adult population.
   Methods. This was a retrospective cross-sectional study involving 24 826 subjects who underwent a health check-up from January 2013 to December 2015. A multivariate linear regression model was developed to analyse the relationship among BMI, serum homocysteine and estimated glomerular filtration rate (eGFR). A multivariate logistic regression model was used to assess the relationship among weight categories, hyperhomocysteinaemia and CKD.
   Results. The prevalence of CKD in the quartile groups of homocysteine were 2.5%, 2.7%, 3.4% and 5.2% (P < 0.01). For every one-unit increase in BMI (kg/m(2)), the eGFR decreased by 0.50 ml/min/1.73 m(2). Overweight/obese subjects with high homocysteine levels had a higher odds ratio (OR) for CKD, as compared with normal weight subjects (1.84 versus 1.38, respectively; P < 0.01 versus P = 0.02, respectively). Overweight/obese female subjects with hyperhomocysteinaemia had an OR of 3.40 [P < 0.01; 95% confidence interval (CI): 2.06-5.61] for CKD; in males, the OR was 1.66 (P < 0.01; 95% CI: 1.38-1.99).
   Conclusions. Patients who are overweight/obese with higher homocysteine levels have an increased risk of CKD, especially females. Additional studies exploring whether the effect of weight loss or homocysteine-lowering therapies such as folic acid, vitamin B12 supplements that may prevent or slow the progression of declining renal function, is warranted.
C1 [Lai, Shih-Han; Tsai, Yi-Wen] Chang Gung Mem Hosp, Dept Family Med, Keelung, Taiwan.
   [Lai, Shih-Han; Tsai, Yi-Wen; Chen, Yi-Chuan] Chang Gung Univ, Coll Med, Taoyuan, Taiwan.
   [Chen, Yi-Chuan] Chang Gung Mem Hosp, Dept Family Med, Linkou, Taiwan.
   [Chang, Shy-Shin] Taipei Med Univ, Taipei Med Univ Hosp, Dept Family Med, Taipei, Taiwan.
   [Chang, Shy-Shin] Taipei Med Univ, Sch Med, Taipei, Taiwan.
   [Chang, Shy-Shin] Chang Gung Univ, Coll Med, Grad Inst Clin Med Sci, Taoyuan, Taiwan.
C3 Chang Gung Memorial Hospital; Chang Gung University; Chang Gung Memorial
   Hospital; Taipei Medical University Hospital; Taipei Medical University;
   Taipei Medical University; Chang Gung University
RP Chang, SS (corresponding author), Taipei Med Univ Hospital, Dept Family Med, 252 Wuxing St, Taipei, Taiwan.
EM sschang0529@gmail.com
RI Tsai, Yi-Wen/ABD-6153-2021
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NR 29
TC 11
Z9 12
U1 0
U2 7
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0263-2136
EI 1460-2229
J9 FAM PRACT
JI Fam. Pr.
PD JUN
PY 2018
VL 35
IS 3
BP 259
EP 265
DI 10.1093/fampra/cmx110
PG 7
WC Primary Health Care; Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA GH1WI
UT WOS:000433192900005
PM 29092063
OA Bronze
DA 2025-06-11
ER

PT J
AU Siiskonen, H
   Oikari, S
   Pasonen-Seppönen, S
   Rilla, K
AF Siiskonen, Hanna
   Oikari, Sanna
   Pasonen-Seppanen, Sanna
   Rilla, Kirsi
TI Hyaluronan synthase 1: a mysterious enzyme with unexpected functions
SO FRONTIERS IN IMMUNOLOGY
LA English
DT Review
DE hyaluronan; hyaluronan synthase; CD44; inflammation; cytokines; cancer
ID DIFFERENTIATED TERATOCARCINOMA CELLS; UDP-GLUCOSE DEHYDROGENASE;
   ACTIVATED PROTEIN-KINASE; GROUP-A STREPTOCOCCUS; SMOOTH-MUSCLE-CELLS;
   GROWTH-FACTOR; MESSENGER-RNA; MOLECULAR-CLONING; UP-REGULATION; TGF-BETA
AB Hyaluronan synthase 1 (HAS1) is one of three isoenzymes responsible for cellular hyaluronan synthesis. Interest in HAS1 has been limited because its role in hyaluronan production seems to be insignificant compared to the two other isoenzymes, HAS2 and HAS3, which have higher enzymatic activity. Furthermore, in most cell types studied so far, the expression of its gene is low and the enzyme requires high concentrations of sugar precursors for hyaluronan synthesis, even when overexpressed in cell cultures. Both expression and activity of HAS1 are induced by pro-inflammatory factors like interleukins and cytokines, suggesting its involvement in inflammatory conditions. Has1 is upregulated in states associated with inflammation, like atherosclerosis, osteoarthritis, and infectious lung disease. In addition, both full length and splice variants of HAS1 are expressed in malignancies like bladder and prostate cancers, multiple myeloma, and malignant mesothelioma. Interestingly, immunostainings of tissue sections have demonstrated the role of HAS1 as a poor predictor in breast cancer, and is correlated with high relapse rate and short overall survival. Utilization of fluorescently tagged proteins has revealed the intracellular distribution pattern of HAS 1, distinct from other isoenzymes. In all cell types studied so far, a high proportion of HAS1 is accumulated intracellularly, with a faint signal detected on the plasma membrane and its protrusions. Furthermore, the pericellular hyaluronan coat produced by HAS1 is usually thin without induction by inflammatory agents or glycemic stress and depends on CD44-HA interactions. These specific interactions regulate the organization of hyaluronan into a leukocyte recruiting matrix during inflammatory responses. Despite the apparently minor enzymatic activity of HAS1 under normal conditions, it may be an important factor under conditions associated with glycemic stress like metabolic syndrome, inflammation, and cancer.
C1 [Siiskonen, Hanna] Univ Eastern Finland, Kuopio Univ Hosp, Dept Dermatol, Kuopio 70211, Finland.
   [Oikari, Sanna; Pasonen-Seppanen, Sanna; Rilla, Kirsi] Univ Eastern Finland, Inst Biomed, Kuopio 70211, Finland.
C3 University of Eastern Finland; University of Eastern Finland Hospital;
   Kuopio University Hospital; University of Eastern Finland
RP Rilla, K (corresponding author), Univ Eastern Finland, Inst Biomed, Yliopistonranta 1 E, Kuopio 70211, Finland.
EM kirsi.rilla@uef.fi
OI Rilla, Kirsi/0000-0002-7862-5727
FU Academy of Finland [276426]; Spearhead Funds from the University of
   Eastern Finland (Cancer Center of Eastern Finland); Saimaa Cancer
   Foundation; Cancer Foundation of Northern Savo; Kuopio University
   Hospital; Academy of Finland (AKA) [276426] Funding Source: Academy of
   Finland (AKA)
FX The authors gratefully acknowledge financial support from the Academy of
   Finland (grant 276426), Spearhead Funds from the University of Eastern
   Finland (Cancer Center of Eastern Finland), Saimaa Cancer Foundation,
   Cancer Foundation of Northern Savo, and the Special Government Funding
   of the Kuopio University Hospital.
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NR 121
TC 82
Z9 92
U1 2
U2 19
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-3224
J9 FRONT IMMUNOL
JI Front. Immunol.
PD FEB 5
PY 2015
VL 6
AR 43
DI 10.3389/fimmu.2015.00043
PG 11
WC Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology
GA CI4ZQ
UT WOS:000354762900004
PM 25699059
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU McCall, DO
   McGartland, CP
   McKinley, MC
   Sharpe, P
   McCance, DR
   Young, IS
   Woodside, JV
AF McCall, D. O.
   McGartland, C. P.
   McKinley, M. C.
   Sharpe, P.
   McCance, D. R.
   Young, I. S.
   Woodside, J. V.
TI The effect of increased dietary fruit and vegetable consumption on
   endothelial activation, inflammation and oxidative stress in
   hypertensive volunteers
SO NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
LA English
DT Article
DE Nutrition; Endothelium; Hypertension; Inflammation; Oxidative stress
ID CORONARY-HEART-DISEASE; C-REACTIVE PROTEIN; ADHESION MOLECULES;
   DEPENDENT VASODILATION; MEDITERRANEAN DIET; INSULIN-RESISTANCE;
   METABOLIC SYNDROME; OXIDIZED LDL; BLACK TEA; MARKERS
AB Background and aims: Public health campaigns recommend increased fruit and vegetable (FV) consumption as an effective means of cardiovascular risk reduction. During an 8 week randomised control trial among hypertensive volunteers, we noted significant improvements in endothelium-dependent vasodilatation with increasing FV consumption. Circulating indices of inflammation, endothelial activation and insulin resistance are often employed as alternative surrogates for systemic arterial health. The responses of several such biomarkers to our previously described FV intervention are reported here.
   Methods and results: Hypertensive volunteers were recruited from medical outpatient clinics. After a common 4 week run-in period during which FV consumption was limited to 1 portion per day, participants were randomised to 1, 3 or 6 portions daily for 8 weeks. Venous blood samples for biomarker analyses were collected during the pre and post-intervention vascular assessments. A total of 117 volunteers completed the 12 week study. Intervention-related changes in circulating levels of high sensitivity C-reactive protein (hsCRP), soluble intracellular adhesion molecule-1 (sICAM-1), soluble vascular cell adhesion molecule-1 (sVCAM-1), von Willebrand factor (vWF) and plasminogen activator inhibitor-1 (PAI-1) did not differ significantly between FV groups. Similarly, there were no significant between group differences of change in homeostasis model assessment (HOMA) scores.
   Conclusions: Despite mediating a significant improvement in acetylcholine induced vasodilatation, increased FV consumption did not affect a calculated measure of insulin resistance or concentrations of the circulating biomarkers measured during this study. Functional indices of arterial health such as endothelium-dependent vasomotion are likely to provide more informative cardiovascular end-points during short-term dietary intervention trials. (C) 2010 Elsevier B.V. All rights reserved.
C1 [McCall, D. O.; McGartland, C. P.; McKinley, M. C.; Young, I. S.; Woodside, J. V.] Ctr Publ Hlth, Nutr & Metab Grp, Belfast BT12 6BJ, Antrim, North Ireland.
   [McCance, D. R.] Royal Victoria Hosp, Reg Ctr Endocrinol & Diabet, Belfast BT12 6BA, Antrim, North Ireland.
RP McCall, DO (corresponding author), Ctr Publ Hlth, Nutr & Metab Grp, Lower Ground Floor,Pathol Bldg,Grosvenor Rd, Belfast BT12 6BJ, Antrim, North Ireland.
EM d.o.mccall@qub.ac.uk
OI Young, Ian/0000-0003-3890-3152; Woodside, Jayne/0000-0002-5691-4659;
   McKinley, Michelle/0000-0003-3386-1504
FU United Kingdom's Food Standards Agency; ESRC [ES/G007438/1] Funding
   Source: UKRI
FX This study was funded by the United Kingdom's Food Standards Agency.
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NR 47
TC 27
Z9 29
U1 0
U2 13
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0939-4753
EI 1590-3729
J9 NUTR METAB CARDIOVAS
JI Nutr. Metab. Carbiovasc. Dis.
PD SEP
PY 2011
VL 21
IS 9
BP 658
EP 664
DI 10.1016/j.numecd.2010.01.009
PG 7
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism; Nutrition
   & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism;
   Nutrition & Dietetics
GA 830CW
UT WOS:000295635700007
PM 20392617
DA 2025-06-11
ER

PT J
AU Vogelzangs, N
   Beekman, ATF
   Milaneschi, Y
   Bandinelli, S
   Ferrucci, L
   Penninx, BWJH
AF Vogelzangs, Nicole
   Beekman, Aartjan T. F.
   Milaneschi, Yuri
   Bandinelli, Stefania
   Ferrucci, Luigi
   Penninx, Brenda W. J. H.
TI Urinary Cortisol and Six-Year Risk of All-Cause and Cardiovascular
   Mortality
SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Article
ID PITUITARY-ADRENAL AXIS; MYOCARDIAL-INFARCTION; METABOLIC SYNDROME;
   BLOOD-PRESSURE; STRESS; INFLAMMATION; DECLINE; DISEASE; OBESITY; HEART
AB Context: The stress hormone cortisol has been linked with unfavorable cardiovascular risk factors, but longitudinal studies examining whether high levels of cortisol predict cardiovascular mortality are largely absent.
   Objective: The aim of this study was to examine whether urinary cortisol levels predict all-cause and cardiovascular mortality over 6 yr of follow-up in a general population of older persons.
   Design and Setting: Participants were part of the InCHIANTI study, a prospective cohort study in the older general population with 6 yr of follow-up.
   Participants: We studied 861 participants aged 65 yr and older.
   Main Outcome Measure: Twenty-four-hour urinary cortisol levels were assessed at baseline. In the following 6 yr, all-cause and cardiovascular mortality was ascertained from death certificates. Cardiovascular mortality included deaths due to ischemic heart disease and cerebrovascular disease.
   Results: During a mean follow-up of 5.7 (SD = 1.2) yr, 183 persons died, of whom 41 died from cardiovascular disease. After adjustment for sociodemographics, health indicators, and baseline cardiovascular disease, urinary cortisol did not increase the risk of noncardiovascular mortality, but it did increase cardiovascular mortality risk. Persons in the highest tertile of urinary cortisol had a five times increased risk of dying of cardiovascular disease (hazard ratio = 5.00; 95% confidence interval = 2.02-12.37). This effect was found to be consistent across persons with and without cardiovascular disease at baseline (p interaction = 0.78).
   Conclusions: High cortisol levels strongly predict cardiovascular death among persons both with and without preexisting cardiovascular disease. The specific link with cardiovascular mortality, and not other causes of mortality, suggests that high cortisol levels might be particularly damaging to the cardiovascular system. (J Clin Endocrinol Metab 95: 4959-4964, 2010)
C1 [Vogelzangs, Nicole; Beekman, Aartjan T. F.; Penninx, Brenda W. J. H.] Vrije Univ Amsterdam Med Ctr, Dept Psychiat, NL-1081 HL Amsterdam, Netherlands.
   [Vogelzangs, Nicole; Beekman, Aartjan T. F.; Penninx, Brenda W. J. H.] Vrije Univ Amsterdam Med Ctr, EMGO Inst Hlth & Care Res, NL-1081 HL Amsterdam, Netherlands.
   [Milaneschi, Yuri; Ferrucci, Luigi] NIA, Clin Res Branch, Baltimore, MD 21225 USA.
   [Milaneschi, Yuri] Tuscany Hlth Reg Agcy, I-50125 Florence, Italy.
   [Bandinelli, Stefania] Azienda Sanit Firenze, Geriatr Rehabil, I-50122 Florence, Italy.
C3 Vrije Universiteit Amsterdam; VU UNIVERSITY MEDICAL CENTER; Vrije
   Universiteit Amsterdam; VU UNIVERSITY MEDICAL CENTER; National
   Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA);
   Azienda Sanitaria di Firenze
RP Vogelzangs, N (corresponding author), AJ Ernststr 1187, NL-1081 HL Amsterdam, Netherlands.
EM n.vogelzangs@vumc.nl
RI Ferrucci, Luigi/AED-9724-2022; Beekman, Aartjan T./LUZ-6919-2024;
   Penninx, Brenda/S-7627-2017; bandinelli, stefania/AAL-4570-2020
OI Bandinelli, Stefania/0000-0002-6491-0850; Ferrucci,
   Luigi/0000-0002-6273-1613; Milaneschi, Yuri/0000-0002-3697-6617
FU Italian Ministry of Health [ICS 110.1/RS97.71]; U.S. National Institute
   on Aging [263 MD 916413, 263 MD 821336]; National Heart, Lung, and Blood
   Institute [1R01-HL972972]; Laboratory of Epidemiology, Demography, and
   Biometry, National Institute on Aging
FX The InCHIANTI study was supported as a targeted project (Grant ICS
   110.1/RS97.71) by the Italian Ministry of Health and in part by the U.S.
   National Institute on Aging (Grants 263 MD 916413 and 263 MD 821336).
   Data analyses were supported through Grant 1R01-HL972972 from the
   National Heart, Lung, and Blood Institute. Cortisol assays were
   supported by a professional services contract from the Laboratory of
   Epidemiology, Demography, and Biometry, National Institute on Aging.
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NR 36
TC 104
Z9 115
U1 0
U2 5
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0021-972X
EI 1945-7197
J9 J CLIN ENDOCR METAB
JI J. Clin. Endocrinol. Metab.
PD NOV
PY 2010
VL 95
IS 11
BP 4959
EP 4964
DI 10.1210/jc.2010-0192
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 675QB
UT WOS:000283844400040
PM 20739384
OA Bronze, Green Accepted, Green Published
DA 2025-06-11
ER

PT J
AU Stoian, A
   Muntean, C
   Baba, DF
   Manea, A
   Dénes, L
   Simon-Szabó, Z
   Kosovski, IB
   Nemes-Nagy, E
   Gliga, FI
   Stoian, M
AF Stoian, Adina
   Muntean, Carmen
   Baba, Dragos-Florin
   Manea, Andrei
   Denes, Lorand
   Simon-Szabo, Zsuzsanna
   Kosovski, Irina Bianca
   Nemes-Nagy, Eniko
   Gliga, Florina Ioana
   Stoian, Mircea
TI Update on Biomarkers of Chronic Inflammatory Processes Underlying
   Diabetic Neuropathy
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE diabetic neuropathy; type 2 diabetes mellitus (T2DM); inflammation;
   Toll-like receptor 4 (TLR4); caveolin 1; vitamin D
ID NF-KAPPA-B; PERIPHERAL NEUROPATHY; INSULIN-RESISTANCE; MOUSE MODEL;
   TNF-ALPHA; VITAMIN-D; RECEPTOR EXPRESSION; FUNCTIONAL RECOVERY; SENSORY
   NEUROPATHY; METABOLIC SYNDROME
AB There is an increasing prevalence of diabetes mellitus (DM), particularly type 2 DM (T2DM), and its associated complications. T2DM is linked to insulin resistance, chronic inflammation, and oxidative stress, which can lead to both macrovascular and microvascular complications, including peripheral diabetic neuropathy (PDN). Inflammatory processes play a key role in the development and progression of T2DM and its complications, with specific markers like C-reactive protein (CRP), interleukins (ILs), and tumor necrosis factor (TNF)-alpha being associated with increased risk. Other key inflammatory markers such as nuclear factor kappa B (NF-kappa B) are activated under hyperglycemic and oxidative stress conditions and contribute to the aggravation of PDN by regulating inflammatory gene expression and enhancing endothelial dysfunction. Other important roles in the inflammatory processes are played by Toll-like receptors (TLRs), caveolin 1 (CAV1), and monocyte chemoattractant protein 1 (MCP1). There is a relationship between vitamin D deficiency and PDN, highlighting the critical role of vitamin D in regulating inflammation and immune responses. The involvement of macrophages in PDN is also suspected, emphasizing their role in chronic inflammation and nerve damage in diabetic patients. Vitamin D supplementation has been found to reduce neuropathy severity, decrease inflammatory markers, and improve glycemic control. These findings suggest that addressing vitamin D deficiency could offer therapeutic benefits for PDN. These molecular pathways are critical in understanding the pathogenesis of DM complications and may offer potential biomarkers or therapeutic targets including anti-inflammatory treatments, vitamin D supplementation, macrophage phenotype modulation, and lifestyle modifications, aimed at reducing inflammation and preventing PDN. Ongoing and more extensive clinical trials with the aim of investigating anti-inflammatory agents, TNF-alpha inhibitors, and antioxidants are needed to advance deeper into the understanding and treatment of painful diabetic neuropathy.
C1 [Stoian, Adina; Simon-Szabo, Zsuzsanna; Kosovski, Irina Bianca; Gliga, Florina Ioana] George Emil Palade Univ Med Pharm Sci & Technol Ta, Dept Pathophysiol, Targu Mures 540142, Romania.
   [Muntean, Carmen] George Emil Palade Univ Med Pharm Sci & Technol Ta, Dept Pediat 1, Targu Mures 540142, Romania.
   [Baba, Dragos-Florin] Emergency Inst Cardiovasc Dis & Transplantat, Targu Mures 540142, Romania.
   [Baba, Dragos-Florin] George Emil Palade Univ Med Pharm Sci & Technol Ta, Dept Cell & Mol Biol, Targu Mures 540142, Romania.
   [Manea, Andrei] Mures Cty Emergency Hosp, Dept Radiol, Targu Mures 540136, Romania.
   [Denes, Lorand] George Emil Palade Univ Med Pharm Sci & Technol Ta, Fac Med, Dept Anat & Embryol, Targu Mures 540142, Romania.
   [Nemes-Nagy, Eniko] George Emil Palade Univ Med Pharm Sci & Technol Ta, Fac Med English, Dept Chem & Med Biochem, Targu Mures 540142, Romania.
   [Stoian, Mircea] George Emil Palade Univ Med Pharm Sci & Technol Ta, Dept Anesthesiol & Intens Care, Targu Mures 540142, Romania.
RP Dénes, L (corresponding author), George Emil Palade Univ Med Pharm Sci & Technol Ta, Fac Med, Dept Anat & Embryol, Targu Mures 540142, Romania.
EM adina.stoian@umfst.ro; carmen.duicu@umfst.ro;
   dragos-florin.baba@umfst.ro; andrei17v1997@gmail.com;
   lorand.denes@umfst.ro; eniko.nemes-nagy@umfst.ro;
   florina.gliga@umfst.ro; mircea.stoian@umfst.ro
RI Denes, Lorand/AAB-9601-2020; Baba, Dragos-Florin/HJY-7631-2023; Adina,
   Stoian/IAM-2499-2023; Muntean (Duicu), Carmen/MEO-1582-2025; Kosovski,
   Irina-Bianca/IAN-3192-2023; Stoian, Mircea/HZM-4637-2023; Manea,
   Andrei/JYO-9255-2024; Simon-Szabo, Zsuzsanna/AAD-6075-2022
OI Kosovski, Irina-Bianca/0000-0002-1172-8262; Muntean (Duicu),
   Carmen/0000-0002-8056-1339; Mircea, Stoian/0009-0007-6297-0378; Baba,
   Dragos-Florin/0000-0002-4004-9648; Lorand, Denes/0009-0008-8319-8134;
   Simon-Szabo, Zsuzsanna/0000-0002-6655-5987; Manea,
   Andrei/0009-0002-0922-8565
FU George Emil Palade University of Medicine, Pharmacy, Science and
   Technology of Targu Mures, Research [163/8/10.01.2023]; George Emil
   Palade University of Medicine, Pharmacy, Science and Technology of Targu
   Mures
FX This work was supported by George Emil Palade University of Medicine,
   Pharmacy, Science and Technology of Targu Mures, Research Grant number
   163/8/10.01.2023.
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NR 158
TC 4
Z9 5
U1 5
U2 8
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD OCT
PY 2024
VL 25
IS 19
AR 10395
DI 10.3390/ijms251910395
PG 25
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA I7Z3H
UT WOS:001332396800001
PM 39408723
OA gold
DA 2025-06-11
ER

PT J
AU LeBaron, TW
   Kharman, J
   McCullough, ML
AF LeBaron, Tyler W.
   Kharman, Jason
   McCullough, Michael L.
TI An H2 -infused, nitric oxide-producing functional beverage as
   a neuroprotective agent for TBIs and concussions
SO JOURNAL OF INTEGRATIVE NEUROSCIENCE
LA English
DT Article
DE Traumatic brain injury; Molecular hydrogen; Nitric oxide; Inflammation;
   Reactive oxygen specie
ID TRAUMATIC BRAIN-INJURY; HYDROGEN-RICH WATER; CEREBRAL-BLOOD-FLOW;
   L-ARGININE; MOLECULAR-HYDROGEN; METABOLIC SYNDROME; OXIDATIVE STRESS;
   SALINE PROTECTS; ANTIOXIDANT; DAMAGE
AB Traumatic brain injuries (TBIs) are a leading cause of death and disability. Sports-related TBIs are estimated to be more than several million per year. The pathophysiology of TBIs involves high levels of inflammation, oxidative stress, dysregulation of ion homeostasis, mitochondrial dysfunction, and apoptosis. There is also a reduction in cerebral blood flow, leading to hypoxia and reduced removal of metabolic waste, which further exacerbates the injury. There is currently no recognized effective medical treatment or intervention for TBIs, which may in part be due to the difficulty of drug delivery through the blood-brain barrier. Molecular hydrogen has recently emerged as a neuroprotective medical gas against cerebral infarction and neurodegenerative diseases including TBIs. Its small molecular size and nonpolar nature allow it to easily diffuse through the blood-brain barrier, cell membranes and subcellular compartments. Hydrogen has been shown to exert selective anti-inflammatory, antioxidant, and anti-apoptotic effects by regulating various transcription factors and protein phosphorylation cascades. Nitric oxide is another well-recognized medical gas that plays divergent roles in protecting from and in the recovery of TBIs, as well as in contributing to their pathophysiology and injury. Excessive activation of inducible nitric oxide synthase leads to excess inflammation and oxidative/nitrosative damage as well as a paradoxical nitric oxide depletion in the locations it is needed. Hydrogen regulates nitric oxide production and metabolism, which enhances its benefits while reducing its harms. A novel H2-infused, nitric oxide producing beverage, Hydro Shot, may have important neuroprotective benefits for TBIs. We report preliminary indications that Hydro Shot may be a meaningful adjuvant treatment for TBIs.
C1 [LeBaron, Tyler W.] Comenius Univ, Slovak Acad Sci, Ctr Expt Med, Inst Heart Res,Fac Nat Sci, Bratislava 84104, Slovakia.
   [LeBaron, Tyler W.] Mol Hydrogen Inst, Cedar, UT 84720 USA.
   [LeBaron, Tyler W.] Southern Utah Univ, Dept Kinesiol & Outdoor Recreat, Cedar, UT 84720 USA.
   [Kharman, Jason] Corpus Performance, Dallas, TX 11837 USA.
   [McCullough, Michael L.] Med Off, Internal Med, Dallas, TX 75201 USA.
C3 Slovak Academy of Sciences; Centre of Experimental Medicine, SAS;
   Comenius University Bratislava; Institute for Heart Research, SAS; Utah
   System of Higher Education; Southern Utah University
RP LeBaron, TW (corresponding author), Comenius Univ, Slovak Acad Sci, Ctr Expt Med, Inst Heart Res,Fac Nat Sci, Bratislava 84104, Slovakia.; LeBaron, TW (corresponding author), Mol Hydrogen Inst, Cedar, UT 84720 USA.; LeBaron, TW (corresponding author), Southern Utah Univ, Dept Kinesiol & Outdoor Recreat, Cedar, UT 84720 USA.
EM tylerlebaron@suu.edu
RI LeBaron, Tyler/GLT-7071-2022
OI LeBaron, Tyler/0000-0001-9164-6728
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NR 72
TC 2
Z9 2
U1 0
U2 9
PU IMR PRESS
PI ROBINSON
PA 112 ROBINSON RD, ROBINSON, SINGAPORE
SN 0219-6352
EI 1757-448X
J9 J INTEGR NEUROSCI
JI J. Integr. Neurosci.
PD SEP 30
PY 2021
VL 20
IS 3
BP 667
EP 676
DI 10.31083/j.jin2003071
PG 10
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA WB9TL
UT WOS:000703907900015
PM 34645100
OA gold
DA 2025-06-11
ER

PT J
AU Layman, JI
   Pereira, DL
   Chellan, N
   Huisamen, B
   Kotzé, SH
AF Layman, J. I.
   Pereira, D. L.
   Chellan, N.
   Huisamen, B.
   Kotze, S. H.
TI A histomorphometric study on the hepatoprotective effects of a green
   rooibos extract in a diet-induced obese rat model
SO ACTA HISTOCHEMICA
LA English
DT Article
DE Unfermented rooibos; Aspalathus linearis; Hepatic steatosis; Liver
   histology; Non-alcoholic fatty liver disease
ID FATTY LIVER-DISEASE; TEA ASPALATHUS-LINEARIS; INSULIN-RESISTANCE;
   HEPATIC STEATOSIS; METABOLIC SYNDROME; OXIDATIVE STRESS; POLYPHENOLS;
   CELLS; LIPOGENESIS; PRODUCTS
AB Obesity, type two diabetes mellitus and insulin resistance are associated with increased oxidative stress and inflammation. Unfermented green rooibos is an aspalathin rich variant of traditional fermented rooibos (Aspalathus linearis) and has a high polyphenol content. The present study aimed to determine the histologically observable effects of a commercially produced, aspalathin-rich green rooibos extract, Afriplex GRT (TM) (GRE) in a diet-induced obese rat model. Male Wistar rats (N = 28) were randomly assigned to four study groups (n = 7): control (C), green rooibos (GRT), high-fat diet (HFD) and experimental (HFD-GRT) group. Body mass was determined prior to euthanasia and liver mass was determined after death. The left lateral lobe of the liver was processed to wax and stained using haematoxylin and eosin (H & E), Masson's trichrome stain, Gordons and Sweet's reticulin impregnation and periodic acid-Schiff stain. Frozen liver tissue sections were used for Oil red O staining. Morphometric quantification of steatosis, semiquantitative pathology grading and scoring were performed and verified by a veterinary histopathologist. A significant increase in body and liver mass was observed in the HFD groups while co-treatment with green rooibos significantly reduced both. The volume and area of steatosis were significantly increased in the HFD groups while the area of steatosis significantly reduced with green rooibos co-treatment. The percentage, location and type of steatosis as well as presence of inflammation and hepatocellular injury were reduced in the HFD group co-treated with GRE. These findings suggest that a GRE has potential as an anti-steatotic, anti-inflammatory and weight reducing agent in vivo.
C1 [Layman, J. I.; Pereira, D. L.; Kotze, S. H.] Stellenbosch Univ, Fac Med & Hlth Sci, Dept Biomed Sci, Div Clin Anat, Cape Town, South Africa.
   [Huisamen, B.] Stellenbosch Univ, Fac Med & Hlth Sci, Dept Biomed Sci, Div Med Physiol, Stellenbosch, South Africa.
   [Chellan, N.; Huisamen, B.] South African Med Res Council, Biomed Res & Innovat Platform, Tygerberg, South Africa.
C3 Stellenbosch University; Stellenbosch University; South African Medical
   Research Council
RP Kotzé, SH (corresponding author), Univ Stellenbosch, Fac Med & Hlth Sci, Dept Biomed Sci, Div Clin Anat, POB 241, ZA-8000 Cape Town, South Africa.
EM shk@sun.ac.za
RI Chellan, Nireshni/M-3037-2013; Layman-Lemphane, Jodie/GSM-9436-2022
OI Chellan, Nireshni/0000-0001-9968-0998; Kotze, Sanet/0000-0003-0853-2178;
   Layman-Lemphane, Jodie/0000-0003-2636-4892
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NR 64
TC 17
Z9 17
U1 2
U2 11
PU ELSEVIER GMBH
PI MUNICH
PA HACKERBRUCKE 6, 80335 MUNICH, GERMANY
SN 0065-1281
EI 1618-0372
J9 ACTA HISTOCHEM
JI Acta Histochem.
PY 2019
VL 121
IS 5
BP 646
EP 656
DI 10.1016/j.acthis.2019.05.008
PG 11
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA IK8OS
UT WOS:000476855000014
PM 31153588
DA 2025-06-11
ER

PT J
AU Bouhajja, H
   Kacem, FH
   Abdelhedi, R
   Ncir, M
   Dimitrov, JD
   Marrakchi, R
   Jamoussi, K
   Rebai, A
   El Feki, A
   Abid, M
   Ayadi, H
   Kaveri, SV
   Mnif-Feki, M
   Bougacha-Elleuch, N
AF Bouhajja, Houda
   Kacem, Faten Hadj
   Abdelhedi, Rania
   Ncir, Marwa
   Dimitrov, Jordan D.
   Marrakchi, Rim
   Jamoussi, Kamel
   Rebai, Ahmed
   El Feki, Abdelfattah
   Abid, Mohamed
   Ayadi, Hammadi
   Kaveri, Srini V.
   Mnif-Feki, Mouna
   Bougacha-Elleuch, Noura
TI Potential Predictive Role of Lipid Peroxidation Markers for Type 2
   Diabetes in the Adult Tunisian Population
SO CANADIAN JOURNAL OF DIABETES
LA English
DT Article
DE anti Ox-LDL antibodies; insulin resistance; malondialdehyde; obesity;
   oxidative stress; type 2 diabetes
ID LOW-DENSITY-LIPOPROTEIN; OXIDATIVE STRESS; OXIDIZED LDL; METABOLIC
   SYNDROME; ANTIBODY-LEVELS; OBESITY; MELLITUS; COMPLICATIONS;
   ASSOCIATION; MECHANISM
AB Objectives: We evaluated the potential clinical relevance of malondialdehyde (MDA) and autoantibodies to copper oxidized low-density lipoprotein (CuOx-LDL) in type 2 diabetes occurrence.
   Methods: This cross-sectional study enrolled 69 normoglycemic subjects. 18 prediabetic patients and 108 type 2 diabetes patients. MDA concentration was assessed spectrophotomettically. Plasma lgG, IgA and IgM levels to CuOx-LDL were determined by ELISA.
   Results: Plasma MDA levels were considerably higher in obese. prediabetic and type 2 diabetes subjects compared to controls. In multiple linear regression analysis, both MDA and IgA to CuOx-LDL were significantly associated with glucose metabolism markers (p<0.05). Multiple logistic regression analyses showed that high plasma MDA and IgA to CuOx-LDL were independent risk factors for type 2 diabetes (OR 1.196. 95% CI: 1.058 to 1353: p=0.004: OR 1.626, 95% CI: 1.066 to 2.481: 1:0.024; respectively). Importantly, elevated IgA to CuOx-LDL predicted incident diabetes in patients with prediabetes (OR 2.321, 95% CI:1.063 to 5.066: p=0.035). From stratified analyses by body mass index (BMI), both MDA and IgA to CuOx-LDL remained independent predictors of type 2 diabetes occurrence in non-obese subjects (p<0.05). More interesting, elevated IgA to CuOx-LDL levels could be predictors of type 2 diabetes in obese prediabetic subjects (p=0.044). Conversely, neither IgG nor IgM to CuOx-LDL was associated with glucose metabolism markers, obesity or type 2 diabetes.
   Conclusions: Plasma MDA and IgA to CuOx-LDL were significantly associated with blood markers of glucose metabolism. High levels of MDA and IgA to CuOx-LDL could independently predict type 2 diabetes development in normoglycemia and prediabetic subjects. (C) 2017 Canadian Diabetes Association.
C1 [Bouhajja, Houda; Kacem, Faten Hadj; Abid, Mohamed; Mnif-Feki, Mouna] Hedi Chaker Hosp, Dept Endocrinol, Unit Obes & Metab Syndrome, Sfax, Tunisia.
   [Abdelhedi, Rania; Rebai, Ahmed; Ayadi, Hammadi] Ctr Biotechnol Sfax, Lab Mol & Cellular Screening Proc, Sfax, Tunisia.
   [Ncir, Marwa; El Feki, Abdelfattah] Fac Sci Sfax, Anim Ecophysiol Lab, Sfax, Tunisia.
   [Dimitrov, Jordan D.; Kaveri, Srini V.] Sorbonne Univ, Ctr Rech Cordeliers, Paris, France.
   [Dimitrov, Jordan D.; Kaveri, Srini V.] Univ Paris 05, INSERM, Paris, France.
   [Marrakchi, Rim; Jamoussi, Kamel] CHU Hedi Chaker, Biochem Lab, Sfax, Tunisia.
   [Bougacha-Elleuch, Noura] Univ Sfax, Fac Sci Sfax, Lab Mol & Funct Genet, Sfax, Tunisia.
C3 Universite de Sfax; Hopital Hedi Chaker; Centre de Biotechnologie de
   Sfax; Universite de Sfax; Universite de Sfax; Faculty of Sciences Sfax;
   Institut National de la Sante et de la Recherche Medicale (Inserm);
   Universite Paris Cite; Sorbonne Universite; Institut National de la
   Sante et de la Recherche Medicale (Inserm); Universite Paris Cite;
   Universite de Sfax; Hopital Hedi Chaker; Ecole Nationale dIngenieurs de
   Sfax (ENIS); Universite de Sfax; Faculty of Sciences Sfax
RP Bouhajja, H (corresponding author), Univ Hosp Hedi Chaker, Dept Endocrinol, Unit Obes & Metab Syndrome, El Ain Rd, Sfax 3029, Tunisia.
EM bouhajjahouda@yahoo.fr
RI Aseeri, Mohammed/IZP-9219-2023; elfeki, abdelfattah/LKL-6561-2024;
   Dimitrov, Jordan/N-2141-2014; Rebai, Ahmed/AAE-1410-2020
OI Rebai, Ahmed/0000-0002-8954-8683; raja, marrakchi/0000-0001-5183-3131;
   Kaveri, Srini/0000-0002-0837-4053; Dimitrov, Jordan/0000-0001-8536-8995;
   elfeki, abdelfattah/0009-0009-9949-1367; Bougacha-Elleuch,
   Noura/0000-0002-9738-5562
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NR 40
TC 12
Z9 12
U1 0
U2 5
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1499-2671
J9 CAN J DIABETES
JI Can. J. Diabetes
PD JUN
PY 2018
VL 42
IS 3
BP 263
EP 271
DI 10.1016/j.jcjd.2017.06.006
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA GH5AF
UT WOS:000433427400012
PM 28734952
DA 2025-06-11
ER

PT J
AU Yoshida, T
   Akiba, J
   Matsui, T
   Nakamura, K
   Hisamoto, T
   Abe, M
   Ikezono, Y
   Wada, F
   Iwamoto, H
   Nakamura, T
   Koga, H
   Yamagishi, S
   Torimura, T
AF Yoshida, Takafumi
   Akiba, Jun
   Matsui, Takanori
   Nakamura, Kazuo
   Hisamoto, Takao
   Abe, Mitsuhiko
   Ikezono, Yu
   Wada, Fumitaka
   Iwamoto, Hideki
   Nakamura, Toru
   Koga, Hironori
   Yamagishi, Sho-ichi
   Torimura, Takuji
TI Pigment Epithelium-Derived Factor (PEDF) Prevents Hepatic Fat Storage,
   Inflammation, and Fibrosis in Dietary Steatohepatitis of Mice
SO DIGESTIVE DISEASES AND SCIENCES
LA English
DT Article
DE Pigment epithelium-derived factor; Oxidative stress; Steatohepatitis
ID ADENINE-DINUCLEOTIDE PHOSPHATE; SUPPRESSING RAC-1 ACTIVATION; ADIPOSE
   TRIGLYCERIDE LIPASE; PPAR-GAMMA; STELLATE CELLS; LIVER-DISEASE;
   NONALCOHOLIC STEATOHEPATITIS; PROTEIN EXPRESSION; METABOLIC SYNDROME;
   SERUM-LEVELS
AB Pigment epithelium-derived factor (PEDF) has been shown to be a potent inhibitor of inflammation through its anti-oxidative property. Since oxidative response is considered to play the pivotal role of the development and progression of nonalcoholic steatohepatitis (NASH), it is conceivable that PEDF may play a protective role against NASH. In this study, we examined whether administration of PEDF slowed the progression of NASH in mice models.
   Mice were fed methionine- and choline-deficient (MCD) diet with or without intramuscular administration of adenovirus-expressing PEDF (Ad-PEDF). Effects of PEDF administration on NASH were histologically and biochemically evaluated.
   Administration of Ad-PEDF significantly decreased hepatic fat storage as well as serum levels of ALT in MCD diet-fed mice. Dihydroethidium staining showed that MCD diet-triggered oxidative stress was reduced in the liver of Ad-PEDF-administered mice compared to that of PBS- or Ad-LacZ-administered mice. Activation of Kupffer cells and hepatic fibrosis was also inhibited by Ad-PEDF administration. Quantitative real-time RT-PCR revealed that MCD diet up-regulated expressions of TNF-alpha, IL-1 beta, IL-6, TGF-beta, collagen-1, and collagen-3 mRNA, which were also attenuated with Ad-PEDF administration, whereas MCD diet-induced down-regulation of expressions of PPAR-gamma mRNA was restored with Ad-PEDF administration. Furthermore, immunoblotting analysis showed that MCD diet-induced up-regulation of NADPH oxidase components was significantly decreased in Ad-PEDF-administered mice.
   The present results demonstrated for the first time that PEDF could slow the development and progression of steatohepatitis through the suppression of steatosis and inflammatory response in MCD diet-fed mice. Our study suggests that PEDF supplementation may be a novel therapeutic strategy for the treatment of NASH.
C1 [Yoshida, Takafumi; Hisamoto, Takao; Abe, Mitsuhiko; Ikezono, Yu; Wada, Fumitaka; Iwamoto, Hideki; Nakamura, Toru; Koga, Hironori; Torimura, Takuji] Kurume Univ, Sch Med, Dept Med, Div Gastroenterol, Kurume, Fukuoka, Japan.
   [Yoshida, Takafumi; Hisamoto, Takao; Abe, Mitsuhiko; Ikezono, Yu; Wada, Fumitaka; Iwamoto, Hideki; Nakamura, Toru; Koga, Hironori; Torimura, Takuji] Kurume Univ, Sch Med, Kurume Clin Pharmacol Clin, Liver Canc Res Div,Res Ctr Innovat Canc Therapy, 67 Asahi Machi, Kurume, Fukuoka 8300011, Japan.
   [Matsui, Takanori; Yamagishi, Sho-ichi] Kurume Univ, Sch Med, Dept Pathophysiol & Therapeut Diabet Vasc Complic, Kurume, Fukuoka, Japan.
   [Akiba, Jun] Kurume Univ, Sch Med, Dept Diagnost Pathol, Kurume, Fukuoka, Japan.
   [Nakamura, Kazuo] Nakamura Clin, Wakamatsu Ku, Kitakyushu, Fukuoka, Japan.
C3 Kurume University; Kurume University; Kurume University; Kurume
   University
RP Yoshida, T (corresponding author), Kurume Univ, Sch Med, Dept Med, Div Gastroenterol, Kurume, Fukuoka, Japan.; Yoshida, T (corresponding author), Kurume Univ, Sch Med, Kurume Clin Pharmacol Clin, Liver Canc Res Div,Res Ctr Innovat Canc Therapy, 67 Asahi Machi, Kurume, Fukuoka 8300011, Japan.
EM tayoshi@med.kurume-u.ac.jp
OI Matsui, Takanori/0000-0001-9506-7571
FU JSPS [16K09385]; Grants-in-Aid for Scientific Research [17K08776,
   16K09385] Funding Source: KAKEN
FX We thank Yasuko Imamura and Masako Hayakawa for excellent technical help
   and Taeko Narisawa for secretarial assistance. This work was supported
   by JSPS Grant-in-Aid for Scientific Research (C) Grant Number 16K09385
   (TT).
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NR 33
TC 23
Z9 23
U1 0
U2 4
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0163-2116
EI 1573-2568
J9 DIGEST DIS SCI
JI Dig. Dis. Sci.
PD JUN
PY 2017
VL 62
IS 6
BP 1527
EP 1536
DI 10.1007/s10620-017-4550-x
PG 10
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA EV7ZT
UT WOS:000402000800020
PM 28365916
DA 2025-06-11
ER

PT J
AU Eguchi, A
   Lazic, M
   Armando, AM
   Phillips, SA
   Katebian, R
   Maraka, S
   Quehenberger, O
   Sears, DD
   Feldstein, AE
AF Eguchi, Akiko
   Lazic, Milos
   Armando, Aaron M.
   Phillips, Susan A.
   Katebian, Roia
   Maraka, Spyridoula
   Quehenberger, Oswald
   Sears, Dorothy D.
   Feldstein, Ariel E.
TI Circulating adipocyte-derived extracellular vesicles are novel markers
   of metabolic stress
SO JOURNAL OF MOLECULAR MEDICINE-JMM
LA English
DT Article
DE Obesity; Noninvasive biomarker; Extracellular vesicles; Adipocyte stress
   and hypertrophy
ID ADIPOSE-TISSUE INFLAMMATION; INSULIN-RESISTANCE; MACROPHAGE
   POLARIZATION; PROTEOMIC ANALYSIS; HEPATIC STEATOSIS; LIPID DROPLET;
   OBESITY; FAT; MICROPARTICLES; MICROVESICLES
AB We recently reported that stressed adipocytes release extracellular vesicles (EVs) that act as "find-me" signals to promote macrophage migration and activation. In this study, we performed a comprehensive characterization of stressed adipocyte-derived EVs, assessing their antigenic composition, lipidomics, and RNA profiles. Perilipin A was identified as one of the adipose-specific proteins and studied as a potential novel biomarker to detect adipocyte-derived EVs in circulation. Circulating EVs were significantly increased in mice with diet-induced obesity (DIO) and in obese humans with metabolic syndrome compared to lean controls. This increase was associated with decreased glucose tolerance in the DIO mice and metabolic dysfunction, elevated insulin, and homeostatic model assessment of insulin resistance (HOMA-IR) in the obese humans. EVs from both DIO mice and obese humans were enriched in perilipin A, a central gatekeeper of the adipocyte lipid storehouse and a marker of adipocyte differentiation. In obese humans, circulating levels of EVs enriched in perilipin A were dynamic, decreasing 35 % (p < 0.05) after a 3-month reduced calorie diet intervention. This translational study provides an extensive characterization of adipocyte-derived EVs. The findings identify perilipin A as a novel biomarker of circulating EVs of adipocyte origin and support the development of circulating perilipin A-positive EVs as indicators of adipose tissue health.
   aEuro cent Extensive characterization of 3T3L1 EVs identified perilipin A in their composition.
   aEuro cent Circulating EVs are elevated in obese mice and associated with glucose intolerance.
   aEuro cent Circulating EVs are elevated in obese human and correlated with metabolic factors.
   aEuro cent Perilipin A and EV levels are increased in the circulation of obese mice and human.
   aEuro cent Circulating EV and perilipin A levels decrease with low calorie intervention.
C1 [Eguchi, Akiko; Lazic, Milos; Phillips, Susan A.; Feldstein, Ariel E.] UCSD, Dept Pediat, La Jolla, CA 92093 USA.
   [Armando, Aaron M.; Quehenberger, Oswald] UCSD, Dept Pharmacol, La Jolla, CA 92093 USA.
   [Katebian, Roia] Mt Sinai Hosp, Dept Pediat, Chicago, IL 60608 USA.
   [Maraka, Spyridoula] Univ Connecticut, Sch Med, Dept Internal Med, Farmington, CT 06030 USA.
   [Maraka, Spyridoula] Mayo Clin, Div Endocrinol Diabet Metab & Nutr, Rochester, MN 55905 USA.
   [Quehenberger, Oswald] UCSD, Dept Med, La Jolla, CA 92093 USA.
   [Sears, Dorothy D.] UCSD, Div Endocrinol & Metab, La Jolla, CA 92093 USA.
   [Feldstein, Ariel E.] Univ Calif San Diego, Div Pediat Gastroenterol Hepatol & Nutr, 3020 Childrens Way,MC 5030, San Diego, CA 92103 USA.
C3 University of California System; University of California San Diego;
   University of California System; University of California San Diego;
   University of Connecticut; Mayo Clinic; University of California System;
   University of California San Diego; University of California System;
   University of California San Diego; University of California System;
   University of California San Diego
RP Feldstein, AE (corresponding author), UCSD, Dept Pediat, La Jolla, CA 92093 USA.; Feldstein, AE (corresponding author), Univ Calif San Diego, Div Pediat Gastroenterol Hepatol & Nutr, 3020 Childrens Way,MC 5030, San Diego, CA 92103 USA.
EM afeldstein@ucsd.edu
RI Eguchi, Akiko/E-3086-2010; Sears, Dorothy/B-6979-2019
OI Sears, Dorothy/0000-0002-9260-3540; Maraka,
   Spyridoula/0000-0001-7259-132X; Phillips, Susan/0009-0008-0914-1607
FU NIH [U01 AA022489, DK082451]; Gilead research scholars program in liver
   disease; P. Robert Majumder Charitable Foundation
FX The authors would like to thank Dr. Marilyn Farquhar (University of
   California, San Diego, UCSD) for the use of the electron microscopy
   facility; Timo Meerloo for electron microscopy sample preparation; Dr.
   Majid Ghassemian of the Biomolecular and ProteomicsMass Spectrometry
   facility (UCSD) for the proteomics study; Dr. Gary Hardiman, director of
   UCSD Biomedical Genomics Facility (BIOGEM); and Dr. Roman Sasik for
   analysis of the sequencing study. We acknowledge One World Lab for the
   assistance with selecting antibodies and providing test size quantities.
   This work was supported by NIH grant (U01 AA022489) and (DK082451) to
   AEF, Gilead research scholars program in liver disease to AE, and P.
   Robert Majumder Charitable Foundation to DDS.
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NR 41
TC 133
Z9 138
U1 0
U2 25
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0946-2716
EI 1432-1440
J9 J MOL MED
JI J. Mol. Med.
PD NOV
PY 2016
VL 94
IS 11
BP 1241
EP 1253
DI 10.1007/s00109-016-1446-8
PG 13
WC Genetics & Heredity; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Genetics & Heredity; Research & Experimental Medicine
GA EA4EN
UT WOS:000386562500005
PM 27394413
OA Green Accepted
DA 2025-06-11
ER

PT J
AU O'Neill, RF
   Haseen, F
   Murray, LJ
   O'Sullivan, JM
   Cantwell, MM
AF O'Neill, Roisin F.
   Haseen, Farhana
   Murray, Liam J.
   O'Sullivan, Joe M.
   Cantwell, Marie M.
TI A randomised controlled trial to evaluate the efficacy of a 6-month
   dietary and physical activity intervention for patients receiving
   androgen deprivation therapy for prostate cancer
SO JOURNAL OF CANCER SURVIVORSHIP
LA English
DT Article
DE Diet; Physical activity; Prostate cancer; Androgen deprivation therapy;
   Body composition; Quality of life
ID QUALITY-OF-LIFE; FUNCTIONAL ASSESSMENT; SUPPRESSION THERAPY; STYLE
   INTERVENTION; METABOLIC SYNDROME; MEN; OVERWEIGHT; OBESITY; RESISTANCE;
   MORTALITY
AB Treatment of prostate cancer with androgen deprivation therapy (ADT) is associated with an increased fat mass, decreased lean mass, increased fatigue and a reduction in quality of life (QoL). The aim of this study was to evaluate the efficacy of a 6-month dietary and physical activity intervention for prostate cancer patients receiving ADT, to help minimise these side effects.
   Patients (n = 94) were recruited to this study if they were planned to receive ADT for prostate cancer for at least 6 months. Men randomised to the intervention arm received a dietary and exercise intervention, commensurate with UK healthy eating and physical activity recommendations. The primary outcome of interest was body composition; secondary outcomes included fatigue, QoL, functional capacity, stress and dietary change.
   The intervention group had a significant (p < 0.001) reduction in weight, body mass index and percentage fat mass compared to the control group at 6 months; the between-group differences were -3.3 kg (95 % confidence interval (95 % CI) -4.5, -2.1), -1.1 kg/m(2) (95 % CI -1.5, -0.7) and -2.1 % (95 % CI -2.8, -1.4), respectively, after adjustment for baseline values. The intervention resulted in improvements in functional capacity (p < 0.001) and dietary intakes but did not significantly impact fatigue, QoL or stress scores at endpoint.
   A 6-month diet and physical activity intervention can minimise the adverse body composition changes associated with ADT.
   This study shows that a pragmatic lifestyle intervention is feasible and can have a positive impact on health behaviours and other key outcomes in men with prostate cancer receiving ADT.
C1 [O'Neill, Roisin F.; Haseen, Farhana; Murray, Liam J.; Cantwell, Marie M.] Queens Univ Belfast, Ctr Publ Hlth, Canc Epidemiol & Hlth Serv Res Grp, Belfast BT12 6BA, Antrim, North Ireland.
   [O'Sullivan, Joe M.] Queens Univ Belfast, Ctr Canc Res & Cell Biol, Belfast BT12 6BA, Antrim, North Ireland.
   [O'Neill, Roisin F.] Queens Univ Belfast, Royal Victoria Hosp, Inst Clin Sci, Belfast BT12 6BA, Antrim, North Ireland.
C3 Queens University Belfast; Queens University Belfast; Queens University
   Belfast
RP O'Neill, RF (corresponding author), Queens Univ Belfast, Royal Victoria Hosp, Inst Clin Sci, Block B, Belfast BT12 6BA, Antrim, North Ireland.
EM r.oneill@qub.ac.uk
OI O'Sullivan, Joe/0000-0001-6999-2739
FU Department of Employment and Learning, Queen's University Belfast;
   Centre of Excellence for Public Health, Queen's University Belfast
FX Salary costs for this project were covered by the Department of
   Employment and Learning and the Centre of Excellence for Public Health,
   Queen's University Belfast. The authors would like to acknowledge the
   contribution of the administrative and clinical staff at the Northern
   Ireland Cancer Centre, particularly nurses Barbara Harvey and Wendy
   McPhee. Special thanks also to the prostate cancer patients who gave so
   generously of their time.
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   Wing RR, 2011, DIABETES CARE, V34, P1481, DOI 10.2337/dc10-2415
NR 44
TC 54
Z9 57
U1 0
U2 18
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1932-2259
EI 1932-2267
J9 J CANCER SURVIV
JI J. Cancer Surviv.-Res. Pract.
PD SEP
PY 2015
VL 9
IS 3
BP 431
EP 440
DI 10.1007/s11764-014-0417-8
PG 10
WC Oncology; Social Sciences, Biomedical
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Oncology; Biomedical Social Sciences
GA CP2ZF
UT WOS:000359745900006
PM 25916660
DA 2025-06-11
ER

PT J
AU Makovey, J
   Macara, M
   Chen, JS
   Hayward, CS
   March, L
   Seibel, MJ
   Sambrook, PN
AF Makovey, Joanna
   Macara, Monique
   Chen, Jian Sheng
   Hayward, Christopher S.
   March, Lyn
   Seibel, Markus J.
   Sambrook, Philip N.
TI Serum uric acid plays a protective role for bone loss in peri- and
   postmenopausal women: A longitudinal study
SO BONE
LA English
DT Article
DE Bone mineral density; Bone loss; Uric acid; Body composition; Fat mass
ID X-RAY ABSORPTIOMETRY; LONG-TERM PRECISION; MINERAL DENSITY;
   BODY-COMPOSITION; ELDERLY-MEN; METABOLIC SYNDROME; CAROTID
   ATHEROSCLEROSIS; PERIMENOPAUSAL WOMEN; OXIDATIVE STRESS; RISK-FACTOR
AB Objective: Oxidative stress has been linked to osteoporosis. Serum uric acid (UA), a strong endogenous antioxidant, has been associated with higher bone mineral density (BMD), lower bone turnover and lower prevalence of fractures in a large cross-sectional study of men. Whether this relationship is present in women and how UA relates to changes in BMD longitudinally has not been examined.
   Methods: A sample of 356 peri- and postmenopausal women, mean age 60.5 years was studied. Each individual had baseline BMD and body composition measurements by dual energy x-ray absorptiometry (DXA) and at least one repeat measure, on average 9.7 years later. Annual rate of change in BMD (A%Delta BMD) was calculated. UA was measured at each DXA visit. Calciotropic hormones and bone turnover markers were measured at the final visit only.
   Results: Cross-sectional data analyses revealed that women with higher UA levels had significantly higher absolute BMD measures at all skeletal sites. These women also had higher measures of body weight and its components such as lean mass (LM) and fat mass (FM). Results of multiple regression analyses showed a positive association between UA and BMD that remained significant even after accounting for possible confounders including LM and FM. Regression analyses of the longitudinal BMD data demonstrated significant associations between serum UA levels and annual rates of change in BMD at all skeletal sites. After adjustment associations remained significant for lumbar spine, forearm and whole body BMD but not for hip BMD.
   Conclusion: Higher serum UA levels appear to be protective for bone loss in peri- and postmenopausal women and this relationship is not affected by changes in body composition measures. (C) 2012 Elsevier Inc. All rights reserved.
C1 [Makovey, Joanna; Macara, Monique; Chen, Jian Sheng; March, Lyn; Sambrook, Philip N.] Univ Sydney, Inst Bone & Joint Res, Kolling Inst, Royal N Shore Hosp, Sydney, NSW 2006, Australia.
   [Hayward, Christopher S.] Univ New S Wales, Victor Chang Cardiac Res Inst, Sydney, NSW, Australia.
   [Hayward, Christopher S.] St Vincents Hosp, Dept Cardiol, Sydney, NSW 2010, Australia.
   [Seibel, Markus J.] Univ Sydney, Bone Res Program, ANZAC Res Inst, Sydney, NSW 2006, Australia.
C3 University of Sydney; Kolling Institute of Medical Research; Royal North
   Shore Hospital; Victor Chang Cardiac Research Institute; University of
   New South Wales Sydney; NSW Health; St Vincents Hospital Sydney;
   University of Sydney; ANZAC Research Institute
RP Makovey, J (corresponding author), Royal N Shore Hosp, Dept Rheumatol, Bldg 35,Level 4, St Leonards, NSW 2065, Australia.
EM jmakovey@med.usyd.edu.au
RI March, Lyn/IZP-5723-2023
OI March, Lyn/0000-0003-1736-8111; Seibel, Markus J/0000-0002-2701-378X
FU National Health and Medical Research Council; Australian Twin Registry
FX We would like to thank the National Health and Medical Research Council,
   the Australian Twin Registry and the twins and their families for
   supporting this project.
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NR 54
TC 84
Z9 94
U1 0
U2 15
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 8756-3282
J9 BONE
JI Bone
PD JAN
PY 2013
VL 52
IS 1
BP 400
EP 406
DI 10.1016/j.bone.2012.10.025
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 060BK
UT WOS:000312750700048
PM 23111314
DA 2025-06-11
ER

PT J
AU Tatebe, J
   Morita, T
AF Tatebe, J.
   Morita, T.
TI Enhancement of TNF-α Expression and Inhibition of Glucose Uptake by
   Nicotine in the Presence of a Free Fatty Acid in C2C12 Skeletal Myocytes
SO HORMONE AND METABOLIC RESEARCH
LA English
DT Article
DE C2C12 skeletal myocytes; insulin resistance; oxidative stress; nicotine
ID FACTOR-KAPPA-B; INDUCED INSULIN-RESISTANCE; OXIDATIVE STRESS;
   CIGARETTE-SMOKING; 3T3-L1 ADIPOCYTES; PROTEIN-KINASE; DIABETES-MELLITUS;
   ACTIVATION; MUSCLE; CELLS
AB Smoking is a risk factor for insulin resistance and metabolic syndrome. However, mechanisms responsible for smoking-induced insulin resistance are unclear. We examined the combined effect of nicotine, a toxic substance in tobacco smoke, and palmitate in the serum physiological concentration range on tumor necrosis factor-a (TNF-alpha) expression and impairment of glucose uptake in C2C12 myotubes, since smokers do not have increased serum free fatty acid (FFA) concentrations with insulin resistance compared to nonsmokers. C2C12 myotubes were incubated for 24 h with nicotine (1 mu mol/l) in the presence or absence of palmitate (200 mu mol/l). RT-PCR and Western blotting showed increased TNF-alpha expression in C2C12 myotubes treated with nicotine in the presence of palmitate. Furthermore, stimulation with nicotine in the presence of palmitate enhanced the production of reactive oxygen species (ROS) and activated the protein kinase C-nuclear factor-kappa B (PKC-NF-kappa B) pathway, as detected by dihydroethidium staining and Western blotting, respectively. Consequently, the translocation of GLUT4 to the plasma membrane as well as insulin-stimulated Akt phosphorylation was impaired, and glucose uptake to the myocytes was blocked. In addition, the production of ROS was suppressed by 4-hydroxy-TEMPO, and inhibition of GLUT4 translocation to the plasma membrane was canceled. These results suggest that in C2C12 myotubes, nicotine in the presence of palmitate enhanced the production of ROS and the expression of TNF-alpha through the PKC-NF-kappa B pathway; suppressed GLUT4 translocation to the plasma membrane; and impaired glucose uptake to cells. This pathway represents a possible mechanism by which smoking induces insulin resistance in the body.
C1 [Morita, T.] Toho Univ, Dept Lab Med, Ota Ku, Tokyo 1438540, Japan.
RP Morita, T (corresponding author), Toho Univ, Dept Lab Med, Ota Ku, 5-21-16 Omori Nishi, Tokyo 1438540, Japan.
EM toshimrt@med.toho-u.ac.jp
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NR 33
TC 10
Z9 12
U1 0
U2 5
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0018-5043
EI 1439-4286
J9 HORM METAB RES
JI Horm. Metab. Res.
PD JAN
PY 2011
VL 43
IS 1
BP 11
EP 16
DI 10.1055/s-0030-1267996
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 702SF
UT WOS:000285914900002
PM 21080305
DA 2025-06-11
ER

PT J
AU Dludla, PV
   Cirilli, I
   Marcheggiani, F
   Silvestri, S
   Orlando, P
   Muvhulawa, N
   Moetlediwa, MT
   Nkambule, BB
   Mazibuko-Mbeje, SE
   Hlengwa, N
   Hanser, S
   Ndwandwe, D
   Marnewick, JL
   Basson, AK
   Tiano, L
AF Dludla, Phiwayinkosi V.
   Cirilli, Ilenia
   Marcheggiani, Fabio
   Silvestri, Sonia
   Orlando, Patrick
   Muvhulawa, Ndivhuwo
   Moetlediwa, Marakiya T.
   Nkambule, Bongani B.
   Mazibuko-Mbeje, Sithandiwe E.
   Hlengwa, Nokulunga
   Hanser, Sidney
   Ndwandwe, Duduzile
   Marnewick, Jeanine L.
   Basson, Albertus K.
   Tiano, Luca
TI Bioactive Properties, Bioavailability Profiles, and Clinical Evidence of
   the Potential Benefits of Black Pepper (Piper nigrum) and Red
   Pepper (Capsicum annum) against Diverse Metabolic Complications
SO MOLECULES
LA English
DT Review
DE metabolic disease; oxidative stress; inflammation; pepper; piperine;
   capsaicin; capsinoid
ID ENERGY-EXPENDITURE; OXIDATIVE STRESS; PUNGENT PRINCIPLE; IN-VITRO;
   LIQUID-CHROMATOGRAPHY; TISSUE DISTRIBUTION; INSULIN-RESISTANCE;
   CAPSAICIN RECEPTOR; TOPICAL CAPSAICIN; HEPATIC STEATOSIS
AB The consumption of food-derived products, including the regular intake of pepper, is increasingly evaluated for its potential benefits in protecting against diverse metabolic complications. The current study made use of prominent electronic databases including PubMed, Google Scholar, and Scopus to retrieve clinical evidence linking the intake of black and red pepper with the amelioration of metabolic complications. The findings summarize evidence supporting the beneficial effects of black pepper (Piper nigrum L.), including its active ingredient, piperine, in improving blood lipid profiles, including reducing circulating levels of total cholesterol, low-density lipoprotein cholesterol, and triglycerides in overweight and obese individuals. The intake of piperine was also linked with enhanced antioxidant and anti-inflammatory properties by increasing serum levels of superoxide dismutase while reducing those of malonaldehyde and C-reactive protein in individuals with metabolic syndrome. Evidence summarized in the current review also indicates that red pepper (Capsicum annum), together with its active ingredient, capsaicin, could promote energy expenditure, including limiting energy intake, which is likely to contribute to reduced fat mass in overweight and obese individuals. Emerging clinical evidence also indicates that pepper may be beneficial in alleviating complications linked with other chronic conditions, including osteoarthritis, oropharyngeal dysphagia, digestion, hemodialysis, and neuromuscular fatigue. Notably, the beneficial effects of pepper or its active ingredients appear to be more pronounced when used in combination with other bioactive compounds. The current review also covers essential information on the metabolism and bioavailability profiles of both pepper species and their main active ingredients, which are all necessary to understand their potential beneficial effects against metabolic diseases.
C1 [Dludla, Phiwayinkosi V.; Muvhulawa, Ndivhuwo; Ndwandwe, Duduzile] South African Med Res Council, Cochrane South Africa, ZA-7505 Tygerberg, South Africa.
   [Dludla, Phiwayinkosi V.; Hlengwa, Nokulunga; Basson, Albertus K.] Univ Zululand, Dept Biochem & Microbiol, ZA-9330 Kwa Dlangezwa, South Africa.
   [Cirilli, Ilenia; Marcheggiani, Fabio; Silvestri, Sonia; Orlando, Patrick; Tiano, Luca] Polytech Univ Marche, Dept Life & Environm Sci, I-60131 Ancona, Italy.
   [Muvhulawa, Ndivhuwo; Moetlediwa, Marakiya T.; Mazibuko-Mbeje, Sithandiwe E.] North West Univ, Dept Biochem, Mafikeng Campus, ZA-2735 Mmabatho, South Africa.
   [Nkambule, Bongani B.] Univ KwaZulu Natal, Sch Lab Med & Med Sci, ZA-4000 Durban, South Africa.
   [Hanser, Sidney] Univ Limpopo, Dept Physiol & Environm Hlth, ZA-0727 Sovenga, South Africa.
   [Marnewick, Jeanine L.] Cape Peninsula Univ Technol, Appl Microbial & Hlth Biotechnol Inst, ZA-7535 Bellville, South Africa.
C3 South African Medical Research Council; University of Zululand; Marche
   Polytechnic University; North West University - South Africa; University
   of Kwazulu Natal; University of Limpopo; Cape Peninsula University of
   Technology
RP Dludla, PV (corresponding author), South African Med Res Council, Cochrane South Africa, ZA-7505 Tygerberg, South Africa.; Dludla, PV (corresponding author), Univ Zululand, Dept Biochem & Microbiol, ZA-9330 Kwa Dlangezwa, South Africa.
EM pdludla@mrc.ac.za; ilenia.cirilli@unicam.it; f.marcheggiani@univpm.it;
   s.silvestri@univpm.it; p.orlando@univpm.it; mn.muvhulawa@gmail.com;
   mtdmoetlediwa@gmail.com; nkambuleb@ukzn.ac.za;
   sithandiwe.mazibukombeje@nwu.ac.za; hlengwan@unizulu.ac.za;
   sidney.hanser@ul.ac.za; duduzile.ndwandwe@mrc.ac.za;
   marnewickj@cput.ac.za; bassona@unizulu.ac.za; l.tiano@staff.univpm.it
RI TECHNOLOGY, CAPE PENINSULA UNIVERSITY/L-3761-2019; Nkambule,
   Bongani/ABD-7943-2022; Orlando, Patrick/LSJ-0851-2024; Mazibuko-Mbeje,
   Sithandiwe/HPG-1119-2023; Ndwandwe, Duduzile/L-2296-2013; Tiano,
   Luca/ABC-2341-2020
OI Marcheggiani, Fabio/0000-0002-3272-7525; MOETLEDIWA,
   MARAKIYA/0000-0001-9062-5650; Cirilli, Ilenia/0000-0001-6916-5426;
   Marnewick, Jeanine L/0000-0002-1819-1699; Hanser,
   Sidney/0000-0002-6719-8512; muvhulawa, ndivhuwo/0000-0003-2797-9717;
   Tiano, Luca/0000-0002-7519-7106; Dludla,
   Phiwayinkosi/0000-0001-5965-3610; Hlengwa,
   Nokulunga/0000-0002-4658-1619; Orlando, Patrick/0000-0002-4203-9611
FU South African Medical Research Council [43500]; National Research
   Foundation [132534, 117829]
FX This research is financially backed by the South African Medical
   Research Council under project code 43500, providing support for
   covering the expenses related to processing the article. Funding from
   the National Research Foundation (Grant numbers: 132534 and 117829) for
   the author(P.V.D.) is also acknowledged. The content herein is the sole
   responsibility of the authors and doesnot necessarily represent the
   official views of the SAMRC or the funders
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NR 176
TC 8
Z9 8
U1 2
U2 30
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 1420-3049
J9 MOLECULES
JI Molecules
PD SEP
PY 2023
VL 28
IS 18
AR 6569
DI 10.3390/molecules28186569
PG 24
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA T3FO6
UT WOS:001076877300001
PM 37764345
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Flores-Reséndiz, C
   Soto-Piña, AE
   Valdés-Ramos, R
   Benítez-Arciniega, AD
   Tlatempa-Sotelo, P
   Guadarrama-López, AL
   Martínez-Carrillo, BE
   Pulido-Alvarado, CC
AF Flores-Resendiz, Constantino
   Soto-Pina, Alexandra E.
   Valdes-Ramos, Roxana
   Benitez-Arciniega, Alejandra D.
   Tlatempa-Sotelo, Patricia
   Laura Guadarrama-Lopez, Ana
   Martinez-Carrillo, Beatriz E.
   Pulido-Alvarado, Caroline C.
TI Association Between Cardiovascular Risk Factors and Stress Hormones With
   Cognitive Performance in Mexican Adolescents
SO JOURNAL OF PEDIATRIC PSYCHOLOGY
LA English
DT Article
DE adolescents; cardiovascular risk; cognitive performance; catecholamines;
   cortisol
ID CORTISOL AWAKENING RESPONSE; OVERWEIGHT CHILDREN; ARTERIAL STIFFNESS;
   EXECUTIVE FUNCTION; METABOLIC SYNDROME; MEMORY; PREVALENCE; CORTEX;
   BRAIN; ATTENTION
AB Objective The objective of this study was to determine whether cardiovascular disease (CVD) risk factors and stress hormones are associated with cognitive performance in Mexican adolescents. Methods This was a cross-sectional study including 139 Mexican adolescents 10-14 years old. Participants were divided into three categories: 0, 1-2, and 3 CVD risk factors. These factors included: high-density lipoprotein-cholesterol (HDL-C) <40 mg/dl; waist circumference (WC) 90th percentile for age and sex, systolic or diastolic blood pressure 90th percentile for age, sex, and height; and triacylglycerols (TGs) 110 mg/dl. Low-density lipoprotein-cholesterol (LDL-C), very low-density lipoprotein-cholesterol (VLDL-C), total cholesterol, cortisol, and plasma catecholamines were measured as well. Furthermore, attention, memory, and executive functions were evaluated using a validated test for Spanish-speaking individuals (Neuropsi) Results Adolescents in the three risk categories did not show significant differences in Neuropsi test performance tasks; however, they presented different lipid and plasma norepinephrine concentrations. TG and VLDL-C were inversely associated with memory (r = -0.19, **p < .01). Multivariate regression analysis showed consistently that TG/HDL-C ratio was inversely related to attention-memory general score (standardized beta = -0.99, t = -2.30, p = .023), memory (standardized beta = -0.83, t = -2.08, p = .039), and attention-executive functions (standardized beta = -1.02, t = -2.42, p = .017). Plasma epinephrine levels presented an inverse and weak relation to the attention-executive functions score (standardized beta = -0.18, t = -2.19, p = .030). Conclusions Cognitive performance is not completely dependent on the accumulation of risk factors, but instead on the combination of strong predictors of CVD like waist to height ratio, TG/HDL-C, and VLDL-C. Plasma norepinephrine and epinephrine have a stronger association with cognition and CVD risk than dopamine and cortisol.
C1 [Flores-Resendiz, Constantino; Soto-Pina, Alexandra E.; Valdes-Ramos, Roxana; Benitez-Arciniega, Alejandra D.; Tlatempa-Sotelo, Patricia; Laura Guadarrama-Lopez, Ana; Martinez-Carrillo, Beatriz E.; Pulido-Alvarado, Caroline C.] Univ Autonoma Estado Mexico, Fac Med, Toluca 50180, Estado De Mexic, Mexico.
RP Soto-Piña, AE (corresponding author), Univ Autonoma Estado Mexico, Fac Med, Toluca 50180, Estado De Mexic, Mexico.
EM aesotop@uaemex.mx
RI MARTINEZ, BEATRIZ/B-5456-2016; valdes-ramos, roxana/B-2184-2016;
   Benitez-Arciniega, Alejandra/B-1608-2016; Soto, Alexandra/AAH-4797-2021
OI Benitez-Arciniega, Alejandra Donaji/0000-0002-1051-7420
FU Universidad Autonoma del Estado de Mexico [3861/2015 PIC, 3838/2014
   FSH]; National Council of Science and Technology (CONACYT)
FX This investigation was supported by grants 3861/2015 PIC and 3838/2014
   FSH: from Universidad Autonoma del Estado de Mexico, and a trainee
   fellowship from the National Council of Science and Technology
   (CONACYT).
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NR 59
TC 6
Z9 6
U1 0
U2 5
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0146-8693
EI 1465-735X
J9 J PEDIATR PSYCHOL
JI J. Pediatr. Psychol.
PD MAR
PY 2019
VL 44
IS 2
BP 208
EP 219
DI 10.1093/jpepsy/jsy074
PG 12
WC Psychology, Developmental
WE Social Science Citation Index (SSCI)
SC Psychology
GA HY1VC
UT WOS:000467904200008
PM 30272242
DA 2025-06-11
ER

PT J
AU Nawrot, TS
   Saenen, ND
   Schenk, J
   Janssen, BG
   Motta, V
   Tarantini, L
   Cox, B
   Lefebvre, W
   Vanpoucke, C
   Maggioni, C
   Bollati, V
AF Nawrot, Tim S.
   Saenen, Nelly D.
   Schenk, Julie
   Janssen, Bram G.
   Motta, Valeria
   Tarantini, Letizia
   Cox, Bianca
   Lefebvre, Wouter
   Vanpoucke, Charlotte
   Maggioni, Cristina
   Bollati, Valentina
TI Placental circadian pathway methylation and in utero exposure to
   fine particle air pollution
SO ENVIRONMENT INTERNATIONAL
LA English
DT Article
DE Circadian rhythm; Placenta; DNA methylation; Air pollution; Prenatal;
   CLOCK
ID METABOLIC SYNDROME; DNA METHYLATION; OXIDATIVE STRESS; NITROSATIVE
   STRESS; GENE-EXPRESSION; GENOME BROWSER; CLOCK GENE; EPIGENETICS;
   RHYTHMS; OBESITY
AB In mammals, a central clock maintains the daily rhythm in accordance with the external environment. At the molecular level, the circadian rhythm is maintained by epigenetic regulation of the Circadian pathway. Here, we tested the role of particulate matter with an aerodynamic diameter <= 2.5 mu m (PM2.5) exposure during gestational life on human placental Circadian pathway methylation, as an important molecular target for healthy development. In 407 newborns, we quantified placental methylation of CpG sites within the promoter regions of the following genes: CLOCK, BMAL1, NPAS2, CRY1-2 and PER1-3 using bisulfite-PCR-pyrosequencing. Daily PM2.5 exposure levels were estimated for each mother's residence, using a spatiotemporal interpolation model. We applied mixed-effects models to study the methylation status of the Circadian pathway genes and in utero PM2.5 exposure, while adjusting for a priori chosen covariates. In a multi-gene model, placental Circadian pathway methylation was positively and significantly (p < 0.0001) associated with 3rd trimester PM2.5 exposure. Consequently, the single-gene models showed relative methylation differences [Log(fold change)] in placental NPAS2 (+0.16; p = 0.001), CRY1 (+0.59; p = 0.0023), PER2 (+0.36; p = 0.0005), and PER3 (+0.42; p = 0.0008) for an IQR increase (8.9 mu g/m(3)) in 3rd trimester PM2.5 exposure. PM2.5 air pollution, an environmental risk factor leading to a pro-inflammatory state of the mother and foetus, is associated with the methylation pattern of genes in the Circadian pathway. The observed alterations in the placental CLOCK epigenetic signature might form a relevant molecular mechanism through which fine particle air pollution exposure might affect placental processes and foetal development.
C1 [Nawrot, Tim S.; Saenen, Nelly D.; Schenk, Julie; Janssen, Bram G.; Cox, Bianca] Hasselt Univ, Ctr Environm Sci, Hasselt, Belgium.
   [Nawrot, Tim S.] Leuven Univ, Dept Publ Hlth & Primary Care, Leuven, Belgium.
   [Motta, Valeria; Tarantini, Letizia; Maggioni, Cristina; Bollati, Valentina] Univ Milan, Dept Clin Sci & Community Hlth, EPIGET Epidemiol Epigenet & Toxicol Lab, Milan, Italy.
   [Lefebvre, Wouter] Flemish Inst Technol Res, Mol, Belgium.
   [Vanpoucke, Charlotte] Belgian Interreg Environm Agcy, Brussels, Belgium.
C3 Hasselt University; KU Leuven; University of Milan; VITO
RP Nawrot, TS (corresponding author), Ctr Environm Sci, Agoralaan Bldg D, B-3590 Diepenbeek, Belgium.
EM tim.nawrot@uhasselt.be
RI Saenen, Nelly/JXM-4176-2024; Lefebvre, Wouter/F-5610-2015; Odili,
   Augustine/O-2612-2019; Cox, Bianca/A-9480-2015
OI Lefebvre, Wouter/0000-0002-3277-3118; Cox, Bianca/0000-0001-9824-6276;
   Nawrot, Tim/0000-0002-3583-3593; Saenen, Nelly/0000-0002-3226-089X
FU European Research Council [ERC-2012-StG.310898, ERC-2011-StG. 282413];
   Flemish Scientific Fund (FWO) [G073315N/G082317N]
FX The work is supported by the European Research Council
   (ERC-2012-StG.310898 to T.S.N./ERC-2011-StG. 282413 to V.B.) and by the
   Flemish Scientific Fund (FWO, G073315N/G082317N).
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NR 54
TC 61
Z9 67
U1 1
U2 37
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0160-4120
EI 1873-6750
J9 ENVIRON INT
JI Environ. Int.
PD MAY
PY 2018
VL 114
BP 231
EP 241
DI 10.1016/j.envint.2018.02.034
PG 11
WC Environmental Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology
GA GC6CH
UT WOS:000429877200026
PM 29524919
DA 2025-06-11
ER

PT J
AU Cagnacci, A
   Cannoletta, M
   Palma, F
   Bellafronte, M
   Romani, C
   Palmieri, B
AF Cagnacci, A.
   Cannoletta, M.
   Palma, F.
   Bellafronte, M.
   Romani, C.
   Palmieri, B.
TI Relation between oxidative stress and climacteric symptoms in early
   postmenopausal women
SO CLIMACTERIC
LA English
DT Article
DE FREE RADICALS; ANTIOXIDANT; LIPID; HOT FLUSH; MENOPAUSE; PULSATILITY
   INDEX; CAROTID ARTERY
ID FREE OXYGEN RADICALS; C-REACTIVE PROTEIN; RISK-FACTORS; HOT FLASHES;
   CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; BODY-WEIGHT; MENOPAUSE;
   ASSOCIATION; THERAPY
AB Objectives To evaluate the relation between climacteric symptoms or other risk factors for cardiovascular disease and oxidative status of postmenopausal women.
   Methods Cross-sectional investigation performed at the outpatient service for the menopause at the University Hospital, on 50 apparently healthy women in physiological postmenopause. The whole-blood free oxygen radical test (FORT), free oxygen radical defence (FORD), age, months since menopause, weight, body mass index, waist circumference, waist-to-hip ratio, estradiol, lipids, glucose, insulin, insulin resistance (glucose/insulin and HOMA-IR), and fibrinogen were evaluated. The Greene Climacteric Scale with its subscales was used to evaluate climacteric symptoms. The pulsatility index, an index of downstream blood flow resistance, was determined for both the internal carotid artery and the brachial artery.
   Results The waist-to-hip ratio (r = 0.540; p < 0.0001), estradiol (r = 0.548; p = 0.0004) and waist circumference (r = 0.345; p = 0.02) were independently related to blood FORT. The score in the Greene vasomotor subscale was the only parameter independently related to blood FORD (r = 0.554; p = 0.0001). FORT was not related to the artery pulsatility index, while FORD was negatively related to the pulsatility index of both the internal carotid (r = 0.549; p = 0.0001) and the brachial (r = 0.484; p = 0.0001) arteries.
   Discussion In postmenopausal women, abdominal adiposity and hypoestrogenism increase oxidative stress. Climacteric symptoms, particularly vasomotor symptoms, markedly reduce antioxidant defences. Lower antioxidant defences are associated with higher resistance to blood flow in the great arteries. In women early after the menopause, visceral fat, hypoestrogenism and climacteric symptoms may increase the risk for cardiovascular disease.
C1 [Cagnacci, A.; Cannoletta, M.; Palma, F.; Bellafronte, M.; Romani, C.] Univ Modena & Reggio Emilia, Inst Obstet & Gynecol, Dept Med & Surg Sci Mother Child & Adult, Modena, Italy.
   [Palmieri, B.] Univ Modena & Reggio Emilia, Inst Gen Surg, Dept Surg Med Dent & Morphol Sci Transplantat Onc, Modena, Italy.
C3 Universita di Modena e Reggio Emilia; Universita di Modena e Reggio
   Emilia
RP Cagnacci, A (corresponding author), Policlin Modena, Obstet & Gynecol, Ob Gyn & Pediat, I-41100 Modena, Italy.
EM cagnacci@unimore.it
RI Palma, Federica/JFK-6379-2023; Cannoletta, Marianna/AAM-6783-2021;
   PALMIERI, Beniamino/K-3886-2016; Cagnacci, Angelo/Q-7432-2016
OI PALMIERI, Beniamino/0000-0002-0871-138X; Cagnacci,
   Angelo/0000-0003-2714-623X; Palma, Federica/0009-0007-5771-9816;
   Cannoletta, Marianna/0000-0001-5710-1353
FU  [A.D28.SCCAGN05]
FX Source of funding Partially funded by a liberal donation to Department
   of Medical and Surgical Sciences of the Mother, Child and Adult, grant
   A.D28.SCCAGN05.
CR Bellanti F, 2013, REDOX BIOL, V1, P340, DOI 10.1016/j.redox.2013.05.003
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NR 36
TC 24
Z9 25
U1 0
U2 5
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 1369-7137
EI 1473-0804
J9 CLIMACTERIC
JI Climacteric
PD AUG
PY 2015
VL 18
IS 4
BP 631
EP 636
DI 10.3109/13697137.2014.999659
PG 6
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA CP4IJ
UT WOS:000359844900028
PM 25536006
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Bruynsteen, L
   Janssens, GPJ
   Harris, PA
   Duchateau, L
   Valle, E
   Odetti, P
   Vandevelde, K
   Buyse, J
   Hesta, M
AF Bruynsteen, Lien
   Janssens, Geert P. J.
   Harris, Patricia A.
   Duchateau, Luc
   Valle, Emanuela
   Odetti, Patrizio
   Vandevelde, Kimberley
   Buyse, Johan
   Hesta, Myriam
TI Changes in oxidative stress in response to different levels of energy
   restriction in obese ponies
SO BRITISH JOURNAL OF NUTRITION
LA English
DT Article
DE Ponies; Energy restriction; Weight-loss rate; Oxidative stress
ID WEIGHT-LOSS; ADVANCED GLYCATION; INSULIN SENSITIVITY; DIETARY
   RESTRICTION; LIPID-PEROXIDATION; METABOLIC SYNDROME; END-PRODUCTS;
   HORSES; PLASMA; ANTIOXIDANTS
AB The present study evaluated the effect of different levels of energy restriction on metabolic parameters in obese ponies. Relative weight changes, markers of lipid metabolism and oxidant/antioxidant balance were monitored. A total of eighteen obese (body condition score 7/9) Shetland ponies were studied over a 235-week trial, which was divided into three periods. The first period involved a 4-week adaptation period in which each animal was fed 100% of their maintenance energy requirements needed to maintain a stable obese body weight (MERob). This was followed by a 165-week weight-loss period in which ponies were assigned to receive either 100% (control group, CONTROL), 80% (slow weight-loss (SLOW) group) or 60% (rapid weight-loss (RAPID) group) of their MERob. During the 3-week end-phase period, all ponies were again fed 100% of their MERob. Relative weight loss was higher in the RAPID group (P<0001) compared with the SLOW group. No linear relationship was found as a doubling of the percentage of energy restriction was accompanied by a tripling of the percentage of weight loss. Relative weight gain afterwards in the end-phase period was higher in the RAPID group (P<0001) compared with the SLOW and CONTROL groups. During the weight-loss period, TAG and NEFA concentrations were highest in the RAPID group, as were -tocopherol and ferric-reducing ability of plasma concentrations. After 8 weeks of weight loss, the concentrations of advanced oxidation protein products were higher in the RAPID group compared with the SLOW and CONTROL groups (P<0001). In conclusion, the level of energy restriction influences the extent of changes in oxidant/antioxidant balance. Practically, more severe energy restriction regimens may be associated with a greater regain of weight after the restriction period.
C1 [Bruynsteen, Lien; Janssens, Geert P. J.; Vandevelde, Kimberley; Hesta, Myriam] Univ Ghent, Fac Vet Med, Dept Nutr Genet & Ethol, Anim Nutr Lab, B-9820 Merelbeke, Belgium.
   [Harris, Patricia A.] WALTHAM Ctr Pet Nutr, Equine Studies Grp, Melton Mowbray LE14 4RT, Leics, England.
   [Duchateau, Luc] Univ Ghent, Fac Vet Med, Dept Comparat Physiol & Biometry, B-9820 Merelbeke, Belgium.
   [Valle, Emanuela] Univ Turin, Div Geriatr, Turin, Italy.
   [Odetti, Patrizio] Univ Genoa, Dept Internal Med & Med Special, Div Geriatr, Genoa, Italy.
   [Buyse, Johan] Katholieke Univ Leuven, Dept Biosyst, Lab Livestock Physiol Immunol & Genet Domest Anim, Heverlee, Belgium.
C3 Ghent University; Mars; WALTHAM Petcare Science Institute; Ghent
   University; University of Turin; University of Genoa; KU Leuven
RP Bruynsteen, L (corresponding author), Univ Ghent, Fac Vet Med, Dept Nutr Genet & Ethol, Anim Nutr Lab, Heidestr 19, B-9820 Merelbeke, Belgium.
EM lien.bruynsteen@ugent.be
RI valle, emanuela/AFX-9345-2022; Janssens, Geert/C-2264-2008; valle,
   emanuela/G-5662-2015
OI valle, emanuela/0000-0002-5519-3554; Hesta, Myriam/0000-0001-9423-9765;
   ODETTI, PATRIZIO/0000-0001-9559-7273
FU Institute for Promotion of Innovation through Science and Technology in
   Flanders (IWT) [101572]; WALTHAM-Buckeye Equine Research Grant; Academy
   of Finland (AKA) [101572] Funding Source: Academy of Finland (AKA)
FX The present study was part of the postgraduate study of L. B. and funded
   by the Institute for Promotion of Innovation through Science and
   Technology in Flanders (IWT, grant no. 101572). The study was also
   funded by the 2011 WALTHAM-Buckeye Equine Research Grant. Professor Pat
   Harris, who is affiliated with WALTHAM, was involved in the study design
   and drafting of the manuscript.
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NR 57
TC 20
Z9 21
U1 0
U2 23
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1145
EI 1475-2662
J9 BRIT J NUTR
JI Br. J. Nutr.
PD OCT 28
PY 2014
VL 112
IS 8
BP 1402
EP 1411
DI 10.1017/S0007114514001974
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA AR9IC
UT WOS:000343886000017
PM 25181634
OA Green Submitted, Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Laborie, C
   Molendi-Coste, O
   Breton, C
   Montel, V
   Vandenbulcke, F
   Grumolato, L
   Anouar, Y
   Vieau, D
AF Laborie, C.
   Molendi-Coste, O.
   Breton, C.
   Montel, V.
   Vandenbulcke, F.
   Grumolato, L.
   Anouar, Y.
   Vieau, D.
TI Maternal Perinatal Undernutrition has Long-Term Consequences on
   Morphology, Function and Gene Expression of the Adrenal Medulla in the
   Adult Male Rat
SO JOURNAL OF NEUROENDOCRINOLOGY
LA English
DT Article
DE maternal undernutrition; catecholamine secretion; chromaffin cells;
   perinatal programming
ID SYMPATHETIC-NERVOUS-SYSTEM; HPA AXIS; SYMPATHOADRENAL ACTIVITY;
   PLACENTAL RESTRICTION; DEVELOPMENTAL ORIGINS; GROWTH-RETARDATION;
   METABOLIC SYNDROME; CHROMAFFIN CELLS; STRESS; PROTEIN
AB Epidemiological studies suggest that maternal undernutrition sensitises to the development of chronic adult diseases, such as type 2 diabetes, hypertension and obesity. Although the physiological mechanisms involved in this 'perinatal programming' remain largely unknown, alterations of stress neuroendocrine systems such as the hypothalamic-pituitary-adrenal (HPA) and sympathoadrenal axes might play a crucial role. Despite recent reports showing that maternal perinatal undernutrition disturbs chromaffin cells organisation and activity in male rats at weaning, its long-term effects on adrenal medulla in adult animals are unknown. Using a rat model of maternal perinatal 50% food restriction (FR50) from the second week of gestation until weaning, histochemistry approaches revealed alterations in noradrenergic chromaffin cells aggregation and in cholinergic innervation in the adrenal medulla of 8-month-old FR50 rats. Electron microscopy showed that chromaffin cell granules exhibited ultrastructural changes in FR50 rats. These morphological changes were associated with reduced circulating levels and excretion of catecholamines. By contrast, catecholamine plasma levels were significantly increased after a 16 or 72 h of fasting, indicating that the responsiveness of the sympathoadrenal system to food deprivation was accentuated in FR50 adult rats. Among 384 pituitary adenylate cyclase-activating polypeptide-sensitive genes, we identified 129 genes (33.6%) that were under expressed (ratio < 0.7) in FR50 animals. A large number of these genes are involved in cytoskeleton remodelling and vesicle trafficking. Taken together, our results show that maternal perinatal undernutrition programmes adrenomedullary function and gene expression in adult male rats. Because catecholamines contribute to metabolic homeostasis, as well as arterial blood pressure regulation, the alterations observed in the adrenal medulla of adult male FR50 rats may participate in the programming of chronic adult diseases.
C1 [Laborie, C.; Molendi-Coste, O.; Breton, C.; Montel, V.; Vieau, D.] Univ Lille 1, Unite Environm Perinatal & Croissance, Univ Lille Nord France,EA 4489, Equipe Denutr Remplace Maternelles Perinatales, F-59655 Villeneuve Dascq, France.
   [Vandenbulcke, F.] Univ Lille 1, LGgE, Univ Lille Nord France, F-59655 Villeneuve Dascq, France.
   [Grumolato, L.; Anouar, Y.] Univ Rouen, IFRMP 23, Lab Differenciat & Commun Neuronale & Neuroendocr, INSERM,U982, Mont St Aignan, France.
C3 Universite de Lille; Universite de Lille; Institut National de la Sante
   et de la Recherche Medicale (Inserm); Universite de Rouen Normandie
RP Laborie, C (corresponding author), Univ Lille 1, Unite Environm Perinatal & Croissance, Univ Lille Nord,EA 4489, Equipe Denutr Remplace Maternelles Perinatales, F-59655 Villeneuve Dascq, France.
EM christine.laborie@univ-lille1.fr
RI Anouar, Youssef/F-9683-2017; Molendi-Coste, Olivier/HKW-3196-2023;
   grumolato, luca/A-1697-2015
OI vieau, didier/0000-0002-3254-3662; Montel, Valerie/0000-0002-7286-4209;
   grumolato, luca/0000-0001-8231-3032; Molendi-Coste,
   Olivier/0000-0002-0498-9456; Vandenbulcke, Franck/0000-0002-9735-1784
FU Conseil regional du Nord-Pas de Calais and Lille-Amiens-Rouen-Caen
   (LARC) Neurosciences
FX The authors wish to thank A. Dickes-Coopman for technical assistance. We
   are grateful to G. Courtand (CCMIC, University of Lille 1, France) for
   providing access to microscope facilities and for helping us with AChE
   activity analysis. This study was supported by the Conseil regional du
   Nord-Pas de Calais and Lille-Amiens-Rouen-Caen (LARC) Neurosciences. The
   authors declare that there are no conflicts of interest.
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NR 80
TC 14
Z9 14
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0953-8194
EI 1365-2826
J9 J NEUROENDOCRINOL
JI J. Neuroendocrinol.
PD AUG
PY 2011
VL 23
IS 8
BP 711
EP 724
DI 10.1111/j.1365-2826.2011.02159.x
PG 14
WC Endocrinology & Metabolism; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology
GA 791GV
UT WOS:000292654000006
PM 21564351
DA 2025-06-11
ER

PT J
AU Zhang, YY
   Han, P
   Wu, N
   He, B
   Lu, Y
   Li, SW
   Liu, Y
   Zhao, S
   Liu, LT
   Li, Y
AF Zhang, Yongyan
   Han, Ping
   Wu, Na
   He, Bing
   Lu, Yan
   Li, Shuwen
   Liu, Yang
   Zhao, Sheng
   Liu, Letong
   Li, Yan
TI Amelioration of Lipid Abnormalities by α-Lipoic acid Through
   Antioxidative and Anti-Inflammatory Effects
SO OBESITY
LA English
DT Article
ID LOW-DENSITY-LIPOPROTEIN; INSULIN SENSITIVITY; OXIDATIVE STRESS;
   METABOLIC SYNDROME; RISK-FACTORS; RESISTANCE; ASSOCIATION; OBESITY;
   HYPERTRIGLYCERIDEMIA; HYPERGLYCEMIA
AB Recent data have revealed that oxidative products and inflammatory mediators are increased in the insulin-resistant states of obesity and type 2 diabetes mellitus (T2DM). Obese patients with impaired glucose tolerance (IGT) are at high risk for developing T2DM and have high incidence of dyslipidemia. alpha-Lipoic acid (ALA) is a potent antioxidant with insulin sensitizing activity. However, it is not clear whether ALA is effective on lipid parameters in humans. This study has investigated 22 obese subjects with IGT (obese-IGT), 13 of whom underwent 2-week ALA treatment, 600 mg intravenously once daily. Before and after the treatment, euglycemic-hyperinsulinemic clamps were used to measure insulin sensitivity. Meanwhile, plasma lipids, oxidative products, and chronic inflammatory markers were measured. After treatment of ALA in obese-IGT patients, insulin sensitivity was improved, insulin sensitivity index (ISI) impressively enhanced by 41%. Plasma levels of free fatty acids (FFAs), triglyceride (TG), total cholesterol (T-Chol), low density lipoprotein-cholesterol (LDL-Chol), small dense LDL-Chol (sd-LDL), oxidized LDL-Chol (ox-LDL-Chol), very low density lipoprotein-cholesterol (VLDL-Chol) were all significantly decreased (P < 0.01). At the same time, both plasma oxidative products (malondialdehyde (MDA), 8-iso-prostaglandin) and inflammatory markers (tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6)) were remarkably decreased (P < 0.01), while adiponectin was increased (P < 0.01). There are significant negative correlations between ISI and plasma FFAs, sd-LDL-Chol, ox-LDL-Chol, MDA, 8-iso-prostaglandin, TNF-alpha, and IL-6, and positive correlations with HDL-Chol and adiponectin in obese-IGT patients. The results indicate that short-term treatment with ALA can improve insulin sensitivity and plasma lipid profile possibly through amelioration of oxidative stress and chronic inflammatory reaction in obese patients with IGT.
C1 [Zhang, Yongyan; Han, Ping; Wu, Na; He, Bing; Lu, Yan; Li, Shuwen; Liu, Yang; Zhao, Sheng; Liu, Letong; Li, Yan] China Med Univ, Shengjing Hosp, Dept Endocrinol, Shenyang, Peoples R China.
C3 China Medical University
RP Han, P (corresponding author), China Med Univ, Shengjing Hosp, Dept Endocrinol, Shenyang, Peoples R China.
EM hanping85@hotmail.com
RI He, Bing/AAW-4869-2020
FU Bureau of Education of Liaoning Province, China [20060999]
FX This study was supported by Research Fund from the Bureau of Education
   of Liaoning Province, China (Grant No. 20060999). The authors would like
   to express particular gratitude to Prof Li Shuqin and Yuan Qiang for
   their technical support.
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NR 42
TC 102
Z9 107
U1 1
U2 17
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1930-7381
EI 1930-739X
J9 OBESITY
JI Obesity
PD AUG
PY 2011
VL 19
IS 8
BP 1647
EP 1653
DI 10.1038/oby.2011.121
PG 7
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 797XI
UT WOS:000293163000016
PM 21593803
OA Bronze
DA 2025-06-11
ER

PT J
AU Rasheed, MU
   Naqvi, SAR
   Rasool, N
   Shah, SAA
   Zakaria, ZA
AF Rasheed, Mamoon Ur
   Naqvi, Syed Ali Raza
   Rasool, Nasir
   Shah, Syed Adnan Ali
   Zakaria, Zainul Amiruddin
TI Anti-Diabetic and Cytotoxic Evaluation of Phlomis stewartii Plant
   Phytochemicals on Cigarette Smoke Inhalation and Alloxan-Induced
   Diabetes in Wistar Rats
SO METABOLITES
LA English
DT Article
DE inflammation; antidiabetic; oxidative stress; metabolic syndrome; P;
   stewartii Hf; diabetes mellitus
ID EXTRACTS; MODEL
AB The generation of free radicals in body causes oxidative stress and consequently different metabolic disorders. There are numerous environmental and emotional factors that trigger free radical generation, cigarette smoke (CS) is one of them. In addition to free radical production, it also increases the risk of developing type II diabetes, cancer, and has adverse effects on other organs such as liver and kidneys. In the present study, extracts of leaves, flower, and whole plant of P. stewartii Hf. in methanol were analyzed using LC-ESI-MS and investigated for their cytotoxic properties against HepG2 cell line and CS alloxan-induced diabetes in Wistar albino rats model. A total of 24 rats were kept in aerated cage for eight weeks and exposed to CS following the administration of single dose of alloxan@140 mg/kg body weight at the end of six weeks to induce diabetes mellitus (DM). The cytotoxic activity of extracts against HepG2 was recorded in the order; leaves methanol (LM) > flower methanol (FM) and whole plant methanol (WPM). The IC50(1/4) values were in the order of 187 (LM) > 280 (FM) > 312 (WPM) mu g/mL against HepG2. In positive control group, CS- and alloxan-induced diabetes significantly increased (p < 0.05) the level of alanine alkaline phosphatase (ALP), aminotransferase (ALT), aspartate aminotransferase (AST), low density lipoprotein (LDL), bilirubin, total protein, creatinine, uric acid, blood urea, globulin, total oxidant status (TOS), and malondialdehyde (MDA), as compared to negative control group. In conclusion, according to the results of this study, P. Stewartii methanol extracts showed good antioxidant, anticancer activity and worked well to recover the tested clinical parameters in CS/alloxan-induced diabetes animals, which indicated the extracts also possess good antidiabetic, hepatoprotective, and nephroprotective potential.
C1 [Rasheed, Mamoon Ur; Naqvi, Syed Ali Raza; Rasool, Nasir] Govt Coll Univ, Dept Chem, Faisalabad 38040, Pakistan.
   [Shah, Syed Adnan Ali] Univ Teknol MARA, Fac Pharm, Cawangan Selangor Kampus Puncak Alam, Bandar Puncak Alam 42300, Selangor, Malaysia.
   [Shah, Syed Adnan Ali] Univ Teknol MARA, Atta ur Rahman Inst Nat Prod Discovery AuRIns, Cawangan Selangor Kampus Puncak Alam, Bandar Puncak Alam 42300, Selangor, Malaysia.
   [Zakaria, Zainul Amiruddin] Sabah Univ Malaysia, Fac Med & Hlth Sci, Malaysia Borneo Res Algesia Inflammat & Neurodegen, Jalan UMS, Kota Kinabalu 88400, Sabah, Malaysia.
C3 Government College University Faisalabad; Universiti Teknologi MARA;
   Universiti Teknologi MARA
RP Naqvi, SAR (corresponding author), Govt Coll Univ, Dept Chem, Faisalabad 38040, Pakistan.
EM draliraza@gcuf.edu.pk
RI Naqvi, Prof. Dr. Syed Ali Raza/I-5246-2019; Zakaria, Zainul/K-9955-2019;
   Rasool, Nasir/ABC-6212-2021; SHAH, ASSOC. PROF. DR. SYED
   ADNAN/HKF-0223-2023; Zakaria, Zainul Amiruddin/S-9933-2018; Naqvi, Syed
   Ali Raza/AFL-7954-2022; Shah, Assoc. Prof. Dr. Syed Adnan
   Ali/O-8836-2016
OI Zakaria, Zainul Amiruddin/0000-0001-5525-7821; Naqvi, Syed Ali
   Raza/0000-0002-2172-9066; Shah, Assoc. Prof. Dr. Syed Adnan
   Ali/0000-0002-8142-5013; Rasool, Nasir/0000-0001-9205-4513
FU Ministry of Higher Education (MOHE) Malaysia, Fundamental Research Grant
   Scheme (FRGS) [FRGS/1/2019/STG05/UITM/02/9]; Universiti Teknologi
   [600-IRMI/FRGS 5/3 (424/2019)]
FX Ministry of Higher Education (MOHE) Malaysia, Fundamental Research Grant
   Scheme (FRGS) (FRGS/1/2019/STG05/UITM/02/9). The Universiti Teknologi
   (600-IRMI/FRGS 5/3 (424/2019).
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NR 61
TC 9
Z9 9
U1 0
U2 5
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2218-1989
J9 METABOLITES
JI Metabolites
PD NOV
PY 2022
VL 12
IS 11
AR 1133
DI 10.3390/metabo12111133
PG 16
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 6W2UH
UT WOS:000895587300001
PM 36422273
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Moradi, F
   Heidari, Z
   Teimori, A
   Ghazvini, M
   Imani, ZF
   Naeini, AA
AF Moradi, Fateme
   Heidari, Zahra
   Teimori, Azam
   Ghazvini, Mohammadreza
   Imani, Zahra Faghih
   Naeini, Amirmansour Alavi
TI The Association Between the Dietary Inflammatory Index (DII) and Some
   Serum Oxidative Stress Markers in Non-Alcoholic Fatty Liver Disease:
   Case- Control
SO INTERNATIONAL JOURNAL OF PREVENTIVE MEDICINE
LA English
DT Article
DE Dietary inflammatory index malondialdehyde; non-alcoholic fatty liver
   disease; total antioxidant capacity
ID METABOLIC SYNDROME; SYSTEMIC INFLAMMATION; RISK; EPIDEMIOLOGY; MORTALITY
AB Purpose: Non-alcoholic fatty liver disease (NAFLD) is the most common liver disorder. The purpose of this study was to determine the relationship between the dietary inflammatory index (DII) and the serum oxidative stress markers in patients with NAFLD. Methods: In this case-control study, 121 patients with NAFLD and 119 healthy subjects were frequency-matched on gender. DII scores were calculated by using a 168-item food frequency questionnaire (FFQ). Blood samples were collected to measure serum oxidative markers. Linear regression and odds ratio (OR) were also used in this study. Results: The mean +/- standard deviation of age for case and control group was 38.04 +/- 6.7 and 35.6 +/- 10.2, respectively. The gender ratio (female to male) for the case and control group was 1:1.42 and 1:1.38, respectively. The mean of the DII in the patient group was significantly higher than the healthy group, (P-values < 0.01). There was a significant negative relationship between TAC and DII (B = -2.63 (95%CI: -4.59, -0.68) and there was also a positive relationship between Malondialdehyde (MDA) and DII (B = 0.15 (95%CI: 0.02, 0.28) in the healthy group, but they were not significant in the case group. After multivariate adjustment, subjects in the most pro-inflammatory DII group had 73 times higher odds of NAFLD compared to subjects in tertile 1 (OR = 72.9; 95%CI (14.3-371.9)). Conclusions: Our findings suggest a direct association between the pro inflammatory properties of diet in patient and healthy group, but no relationship between TAC, MDA, and DII in the case group.
C1 [Moradi, Fateme; Naeini, Amirmansour Alavi] Isfahan Univ Med Sci, Sch Nutr & Food Sci, Dept Community Nutr, Esfahan, Iran.
   [Heidari, Zahra] Isfahan Univ Med Sci, Sch Hlth, Dept Biostat & Epidemiol, Esfahan, Iran.
   [Teimori, Azam] Isfahan Univ Med Sci, Dept Internal Med, Sch Med, Esfahan, Iran.
   [Ghazvini, Mohammadreza] Isfahan Ctr Hlth Res, Natl Inst Hlth Res, Esfahan, Iran.
   [Imani, Zahra Faghih] Isfahan Univ Med Sci, Sch Nutr & Food Sci, Dept Clin Nutr, Esfahan, Iran.
C3 Isfahan University of Medical Sciences; Isfahan University of Medical
   Sciences; Isfahan University of Medical Sciences; Isfahan University of
   Medical Sciences
RP Naeini, AA (corresponding author), Isfahan Univ Med Sci, Sch Nutr & Food Sci, Dept Community Nutr, Esfahan, Iran.
EM am.alavi@nutr.mui.ac.ir
RI heidari, zahra/AAO-8370-2021; , AzamTeimouri/AAF-7146-2019
FU Isfahan University of Medical Sciences [IR.MUI.REC. 1398.279]
FX This work was supported by the Isfahan University of Medical Sciences
   number (code: IR.MUI.REC. 1398.279).
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NR 44
TC 8
Z9 10
U1 0
U2 0
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, Maharashtra, INDIA
SN 2008-7802
EI 2008-8213
J9 INT J PREVENTIVE MED
JI Int. J. Preventive Med.
PD JAN-DEC
PY 2022
VL 13
IS 1
DI 10.4103/ijpvm.IJPVM_411_20
PG 8
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA 3O6CR
UT WOS:000836923700009
PM 35958363
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Gajewska, J
   Ambroszkiewicz, J
   Szamotulska, K
   Klemarczyk, W
   Weker, H
   Chelchowska, M
AF Gajewska, Joanna
   Ambroszkiewicz, Jadwiga
   Szamotulska, Katarzyna
   Klemarczyk, Witold
   Weker, Halina
   Chelchowska, Magdalena
TI Associations Between Antioxidant Vitamin Status, Dietary Intake, and
   Retinol-binding Protein 4 Levels in Prepubertal Obese Children After
   3-month Weight Loss Therapy
SO JOURNAL OF CLINICAL RESEARCH IN PEDIATRIC ENDOCRINOLOGY
LA English
DT Article
DE Vitamin A; vitamin E; retinol-binding protein 4; prepubertal period;
   weight loss therapy
ID METABOLIC SYNDROME; OXIDATIVE STRESS; INSULIN-RESISTANCE; BETA-CAROTENE;
   SERUM RETINOL; INFLAMMATION; ADIPOSITY; RETINOL-BINDING-PROTEIN-4;
   INTERVENTION; ADIPONECTIN
AB Objective: Adiposity is associated with increased oxidative stress, leading to changed fat-soluble vitamin concentrations. The aim of this study was to determine whether weight loss alters fat-soluble vitamin status and whether these alterations are associated with dietary intake, anthropometric parameters and adipokines in obese children.
   Methods: Vitamin A and E concentrations were measured using high-pressure liquid chromatography in 60 obese children before and after weight loss therapy. Retinol-binding protein 4 (RBP4), leptin, soluble leptin receptor (sOB-R), and high molecular weight adiponectin concentrations were determined by immunoenzymatic assays.
   Results: The intake of vitamin E was lower in obese children with weight loss after therapy (p=0.038). In this group, an increase was found in the vitamin A/lipids (p=0.022) and the vitamin E/lipids (p=0.008) ratios but due to the reduction in triglyceride levels. In the obese group, changes in vitamin E level were positively correlated with changes in dietary vitamin E (p=0.017) and the leptin/ sOB-R ratio (p=0.046). Changes in vitamin A level were positively correlated with changes in dietary vitamin A (p=0.001) and RBP4 concentration (p=0.023). Associations between changes in RBP4 level with the changes in body mass index (BMI) (p=0.011) and total cholesterol concentration (p=0.023) but not with changes in vitamin A concentration were found in the obese after therapy.
   Conclusion: An increased risk of vitamin E deficiency may occur in children losing weight during lifestyle intervention. Changes in BMI value may influence changes in RBP4 concentrations and consequently the vitamin A status in obese children after therapy.
C1 [Gajewska, Joanna; Ambroszkiewicz, Jadwiga; Chelchowska, Magdalena] Inst Mother & Child Hlth, Dept Screening & Metab Diagnost, Warsaw, Poland.
   [Szamotulska, Katarzyna] Inst Mother & Child Hlth, Dept Epidemiol & Biostat, Warsaw, Poland.
   [Klemarczyk, Witold; Weker, Halina] Inst Mother & Child Hlth, Dept Nutr, Warsaw, Poland.
RP Gajewska, J (corresponding author), Inst Mother & Child Hlth, Dept Screening & Metab Diagnost, Warsaw, Poland.
EM joanna.gajewska@imid.med.pl
RI Szamotulska, Katarzyna/K-2303-2012; Ambroszkiewicz, Jadwiga/W-1516-2018;
   Weker, Halina/N-3714-2018; Chelchowska, Magdalena/Y-2951-2018; Gajewska,
   Joanna/F-2414-2019
OI Szamotulska, Katarzyna/0000-0003-1045-7584; Chelchowska,
   Magdalena/0000-0002-6174-6813; Gajewska, Joanna/0000-0002-1349-0155;
   Weker, Halina/0000-0002-5072-2066
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NR 47
TC 4
Z9 5
U1 0
U2 2
PU GALENOS YAYINCILIK
PI FINDIKZADE
PA MOLLA GURANI MAHALLESI KACAMAK SOKAK NO 21, FINDIKZADE, ISTANBUL 34093,
   TURKEY
SN 1308-5727
EI 1308-5735
J9 J CLIN RES PEDIATR E
JI J. Clin Res. Pediatr. Endocrinol.
PD JUN
PY 2021
VL 13
IS 2
BP 187
EP 197
DI 10.4274/jcrpe.galenos.2020.2020.0207
PG 11
WC Endocrinology & Metabolism; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Pediatrics
GA SO4VE
UT WOS:000658971200008
PM 33261247
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Xie, D
   Zhao, HR
   Lu, JM
   He, FR
   Liu, WD
   Yu, W
   Wang, Q
   Hisatome, I
   Yamamoto, T
   Koyama, H
   Cheng, JD
AF Xie, De
   Zhao, Hairong
   Lu, Jiaming
   He, Furong
   Liu, Weidong
   Yu, Wei
   Wang, Qiang
   Hisatome, Ichiro
   Yamamoto, Tetsuya
   Koyama, Hidenori
   Cheng, Jidong
TI High uric acid induces liver fat accumulation via ROS/JNK/AP-1 signaling
SO AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
LA English
DT Article
DE high uric acid; JNK; AP-1 pathway; liver fat accumulation; oxidative
   stress
ID ACTIVATED PROTEIN-KINASE; OXIDATIVE STRESS; HEPATIC STEATOSIS; IN-VIVO;
   HYPERURICEMIA; DISEASE; JNK; STEATOHEPATITIS; EXPRESSION; IMPACT
AB Uric acid is the end metabolite derived from the oxidation of purine compounds. Overwhelming evidence shows the vital interrelationship between hyperuricemia (HUA) and nonalcoholic fatty liver disease (NAFLD). However, the mechanisms for this association remain unclear. In this study, we established a urate oxidase-knockout (Uox-KO) mouse model by clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 technology. To study the correlation between HUA and NAFLD, human HepG2 hepatoma cells were treated in culture medium with high level of uric acid. In vivo, the Uox-KO mice spontaneously developed hyperuricemia and aberrant lipid-metabolism, concomitant with abnormal hepatic fat accumulation. HUA activated c-Jun N-terminal kinase (JNK) in vivo and in vitro. Furthermore, inhibiting JNK activation by a JNK-specific inhibitor, SP600125, decreased fat accumulation and lipogenic gene expression induced by HUA. Overexpression of the lipogenic enzymes fatty acid synthase and acetyl-CoA carboxylase 1 was via activation of JNK, which was blocked by the JNK inhibitor SP600125. HUA activated AP-1 to upregulate lipogenic gene expression via JNK activation. In addition, HUA caused mitochondrial dysfunction and reactive oxygen species production. Pretreatment with the antioxidant N-acetyl-L-cysteine could ameliorate HUA-activated JNK and hepatic steatosis. These data suggest that ROS/JNK/AP-1 signaling plays an important role in HUA-mediated fat accumulation in liver.
   NEW & NOTEWORTHY Hyperuricemia and nonalcoholic fatty liver disease are global public health problems, which are strongly associated with metabolic syndrome. In this study, we demonstrate that uric acid induces hepatic fat accumulation via the ROS/ JNK/AP-1 pathway. This study identifies a new mechanism of NAFLD pathogenesis and new potential therapeutic strategies for HUA-induced NAFLD.
C1 [Xie, De; Zhao, Hairong; Lu, Jiaming; He, Furong; Liu, Weidong; Yu, Wei; Wang, Qiang; Cheng, Jidong] Xiamen Univ, Dept Endocrinol, Xiangan Hosp, Xiamen, Peoples R China.
   [Hisatome, Ichiro] Tottori Univ, Inst Regenerat Med & Biofunct, Grad Sch Med Sci, Div Regenerat Med & Therapeut, Yonago, Tottori, Japan.
   [Yamamoto, Tetsuya; Koyama, Hidenori; Cheng, Jidong] Hyogo Coll Med, Dept Diabet Endocrinol & Clin Immunol, Nishinomiya, Hyogo, Japan.
C3 Xiamen University; Tottori University; Hyogo Medical University
RP Cheng, JD (corresponding author), Xiamen Univ, Dept Endocrinol, Xiangan Hosp, Xiamen, Peoples R China.; Cheng, JD (corresponding author), Hyogo Coll Med, Dept Diabet Endocrinol & Clin Immunol, Nishinomiya, Hyogo, Japan.
EM jidongcheng36@hotmail.com
RI yu, wei/MVY-4499-2025; lu, jm/JPK-3675-2023; zhao, hairong/KVC-0567-2024
OI Zhao, Hairong/0000-0003-0000-8136; xie, de/0000-0002-2127-0558
FU National Natural Science Foundation of China [81570772]; Natural Science
   Foundation of Fujian Province [2020J01018]; Gout Research Foundation
   (Japan)
FX This work was supported by the National Natural Science Foundation of
   China (81570772) , the Natural Science Foundation of Fujian Province
   (2020J01018) , and the Gout Research Foundation (Japan, 2019) .
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NR 49
TC 45
Z9 50
U1 6
U2 65
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0193-1849
EI 1522-1555
J9 AM J PHYSIOL-ENDOC M
JI Am. J. Physiol.-Endocrinol. Metab.
PD JUN
PY 2021
VL 320
IS 6
BP E1032
EP E1043
DI 10.1152/ajpendo.00518.2020
PG 12
WC Endocrinology & Metabolism; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Physiology
GA SN6QR
UT WOS:000658412700003
PM 33900847
DA 2025-06-11
ER

PT J
AU Schiavo, B
   Meza-Figueroa, D
   Vizuete-Jaramillo, E
   Robles-Morua, A
   Angulo-Molina, A
   Reyes-Castro, PA
   Inguaggiato, C
   Gonzalez-Grijalva, B
   Pedroza-Montero, M
AF Schiavo, Benedetto
   Meza-Figueroa, Diana
   Vizuete-Jaramillo, Efrain
   Robles-Morua, Agustin
   Angulo-Molina, Aracely
   Reyes-Castro, Pablo A.
   Inguaggiato, Claudio
   Gonzalez-Grijalva, Belem
   Pedroza-Montero, Martin
TI Oxidative potential of metal-polluted urban dust as a potential
   environmental stressor for chronic diseases
SO ENVIRONMENTAL GEOCHEMISTRY AND HEALTH
LA English
DT Article
DE Metal(loid); Urban dust; Chronic diseases; Health risk; Oxidative
   potential
ID AMBIENT PARTICULATE MATTER; RISK-ASSESSMENT; AIR-POLLUTION;
   HEAVY-METALS; METABOLIC SYNDROME; STREET DUST; EXPOSURE; QUALITY;
   HEALTH; PM2.5
AB Oxidative stress (OS) associated with metals in urban dust has become a public health concern. Chronic diseases linked to general inflammation are particularly affected by OS. This research analyzes the spatial distribution of metals associated with OS, the urban dust ' s oxidative potential (OP), and the occurrence of diseases whose treatments are affected by OS. We collected 70 urban dust samples during pre- and post-monsoon seasons to achieve this. We analyzed particle size distribution and morphology by scanning electron microscopy, as well as metal(loid)s by portable X-ray fluorescence, and OP of dust in artificial lysosomal fluid by using an ascorbic acid depletion assay. Our results show that the mean concentration of Fe, Pb, As, Cr, Cu, and V in pre-monsoon was 83,984.6, 98.4, 23.5, 165.8, 301.3, and 141.9 mg kg(-1), while during post-monsoon was 50,638.8, 73.9, 16.7, 124.3, 178.9, and 133.5 mg kg(-1), respectively. Impoverished areas with the highest presence of cardiovascular, cancer, diabetes, and respiratory diseases coincide with contaminated areas where young adults live. We identified significant differences in the OP between seasons. OP increases during the pre-monsoon (from 7.8 to 237.5 nmol AA min(-1)) compared to the post-monsoon season (from 1.6 to 163.2 nmol AA min(-1)). OP values are much higher than measured standards corresponding to contaminated soil and urban particulate matter, which means that additional sources beside metals cause the elevated OP. The results show no risk from chronic exposure to metals; however, our results highlight the importance of studying dust as an environmental factor that may potentially increase oxidative stress.
C1 [Schiavo, Benedetto] Univ Nacl Autonoma Mexico, Inst Geofis, Mexico City 04150, DF, Mexico.
   [Meza-Figueroa, Diana; Gonzalez-Grijalva, Belem] Univ Sonora, Dept Geol, Hermosillo 83000, Sonora, Mexico.
   [Vizuete-Jaramillo, Efrain; Robles-Morua, Agustin] Inst Tecnol Sonora, Dept Ciencias Agua & Medio Ambiente, Obregon, Mexico.
   [Angulo-Molina, Aracely] Univ Sonora, Dept Ciencias Quim Biol, Hermosillo 83000, Sonora, Mexico.
   [Reyes-Castro, Pablo A.] Colegio Sonora, Ctr Estudios Salud & Soc, Hermosillo, Sonora, Mexico.
   [Inguaggiato, Claudio] Baja California CICESE, Dept Geol, Ctr Invest Cient & Educ Super Ensenada, Ensenada, Baja California, Mexico.
   [Pedroza-Montero, Martin] Univ Sonora, Dept Invest Fis, Hermosillo 83000, Sonora, Mexico.
C3 Universidad Nacional Autonoma de Mexico; Universidad de Sonora;
   Universidad de Sonora; CICESE - Centro de Investigacion Cientifica y de
   Educacion Superior de Ensenada; Universidad de Sonora
RP Schiavo, B (corresponding author), Univ Nacl Autonoma Mexico, Inst Geofis, Mexico City 04150, DF, Mexico.; Meza-Figueroa, D (corresponding author), Univ Sonora, Dept Geol, Hermosillo 83000, Sonora, Mexico.
EM benedetto@igeofisica.unam.mx
RI Schiavo, Benedetto/IYJ-9777-2023; Inguaggiato, Claudio/IAP-1435-2023;
   Meza-Figueroa, Diana/AAN-1387-2021; Reyes, Pablo/AAS-3346-2021;
   Pedroza-Montero, Martin/B-1963-2019; Robles-Morua, Agustin/A-1755-2015
OI Pedroza-Montero, Martin/0000-0003-4190-6477; Schiavo,
   Benedetto/0000-0002-0882-0404; INGUAGGIATO, Claudio/0000-0003-1332-3602;
   Vizuete Jaramillo, Efrain Eduardo/0000-0001-8786-3885; Robles-Morua,
   Agustin/0000-0001-8813-8124; ANGULO-MOLINA, ARACELY/0000-0002-8586-3387;
   Meza-Figueroa, Diana/0000-0002-8934-0321
FU National Council for Sciences and Technology in Mexico (CONACyT)
   [A1-S-29697]
FX National Council for Sciences and Technology in Mexico (CONACyT) Grant
   A1-S-29697 to Professor D. MezaFigueroa. Results of this paper are part
   of a post-doctoral stay carried out by Dr. Benedetto Schiavo funded from
   the same grant and supervised by Dra. Diana Meza-Figueroa.
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NR 90
TC 18
Z9 19
U1 0
U2 23
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0269-4042
EI 1573-2983
J9 ENVIRON GEOCHEM HLTH
JI Environ. Geochem. Health
PD JUN
PY 2023
VL 45
IS 6
BP 3229
EP 3250
DI 10.1007/s10653-022-01403-9
EA OCT 2022
PG 22
WC Engineering, Environmental; Environmental Sciences; Public,
   Environmental & Occupational Health; Water Resources
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering; Environmental Sciences & Ecology; Public, Environmental &
   Occupational Health; Water Resources
GA I0AH9
UT WOS:000864321700001
PM 36197533
DA 2025-06-11
ER

PT J
AU Suwannasual, U
   Lucero, J
   McDonald, JD
   Lund, AK
AF Suwannasual, Usa
   Lucero, JoAnn
   McDonald, Jacob D.
   Lund, Amie K.
TI Exposure to traffic-generated air pollutants mediates alterations in
   brain microvascular integrity in wildtype mice on a high-fat diet
SO ENVIRONMENTAL RESEARCH
LA English
DT Article
DE Air pollution; ox-LDL; LOX-1; BBB; Oxidative stress
ID LOW-DENSITY-LIPOPROTEIN; CIRCULATING OXIDIZED LDL; PARTICULATE MATTER;
   METABOLIC SYNDROME; ENDOTHELIAL-CELLS; ENGINE EXHAUST; LECTIN-LIKE;
   IN-VITRO; POLLUTION; STROKE
AB Air pollution-exposure is associated with detrimental outcomes in the central nervous system (CNS) such as cerebrovascular disorders, including stroke, and neurodegenerative diseases. While the mechanisms of these CNS-related outcomes involved have not been fully elucidated, exposure to traffic-generated air pollutants has been associated with altered blood brain barrier (BBB) integrity and permeability. The current study investigated whether inhalation exposure to mixed vehicle emissions (MVE) alters cerebral microvascular integrity in healthy 3 mo old C57BL/6 mice, as well as whether exposure-mediated effects were exacerbated by a high-fat (HF) vs. low-fat (LF) diet. Mice on each diet were randomly assigned to be exposed to either filtered air (FA) or MVE [100 PM/m(3) vehicle emissions mixture: 30 mu g PM/m(3) gasoline engine + 70 mu g PM/m(3) diesel engine emissions; median size 60 nm; particle mass size distribution median of similar to 1 mu m (range: < 0.5-20 mu m)] for 6 h/d, 7d/wk, for 30d. Using sodium fluorescein as a tracer, we observed a significant increase in BBB permeability in both HF + MVE exposed and HF + FA animals, compared to LF + FA controls. Exposure to HF + MVE also led to a significant increase plasma ox-LDL and ox-LDL scavenger receptors (LOX -1 and CD -36) expression in the cerebral vasculature. Histological analysis revealed decreased expression of TJ protein, claudin-5, associated with increased matrix metalloproteinase (MMP)-9 activity and oxidative stress in the cerebral vasculature of HF + MVE mice, compared to LF + MVE. Such findings indicate that inhalation exposure to traffic -generated pollutants, coupled with a HF diet, results in altered BBB integrity and increased ox-LDL signaling in the cerebral vasculature in a wildtype animal model.
C1 [Suwannasual, Usa; Lucero, JoAnn; Lund, Amie K.] Univ North Texas, Adv Environm Res Inst, Dept Biol Sci, Denton, TX 76201 USA.
   [McDonald, Jacob D.] Lovelace Biomed & Environm Res Inst, Albuquerque, NM 87108 USA.
C3 University of North Texas System; University of North Texas Denton;
   Lovelace Respiratory Research Institute; Lovelace Biomedical &
   Environmental Research Institute
RP Lund, AK (corresponding author), Univ North Texas, EESAT-215,1704 W Mulberry, Denton, TX 76201 USA.
EM amie.lund@unt.edu
RI Suwannasual, Usa/AAJ-8710-2020; Lund, Amie/L-4355-2017
OI Lund, Amie/0000-0002-0878-751X
FU National Institute of Environmental Health Sciences at National
   Institute of Health [R00ES016586]; University of North Texas Research
   Initiation Grant (RIG) [GA93601]; Environmental Protection Agency Center
   Grant [RD-83479601]
FX This work was supported by National Institute of Environmental Health
   Sciences at National Institute of Health [R00ES016586 to A.K.L.], the
   University of North Texas Research Initiation Grant (RIG) [GA93601 to
   A.K.L], and Environmental Protection Agency Center Grant RD-83479601
   [Project 3 to A.K.L., coPI and Project 2 to J.D.M., coPI] for the animal
   exposures.
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NR 55
TC 41
Z9 47
U1 0
U2 24
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0013-9351
EI 1096-0953
J9 ENVIRON RES
JI Environ. Res.
PD JAN
PY 2018
VL 160
BP 449
EP 461
DI 10.1016/j.envres.2017.10.029
PG 13
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA FP3WL
UT WOS:000417548600047
PM 29073573
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Gateva, A
   Assyov, Y
   Velikova, T
   Kamenov, Z
AF Gateva, Antoaneta
   Assyov, Yavor
   Velikova, Tsvetelina
   Kamenov, Zdravko
TI Increased peroxiredoxin 4 levels in patients with prediabetes compared
   to normal glucose tolerance subjects
SO CLINICAL ENDOCRINOLOGY
LA English
DT Article
ID IMPAIRED FASTING GLUCOSE; INSULIN-RESISTANCE; CARDIOVASCULAR-DISEASE;
   OXIDATIVE STRESS; RISK; ATHEROSCLEROSIS; INFLAMMATION; MORTALITY;
   PROTECTS
AB Background Peroxiredoxin 4 is a part of endogen antioxidant system and its levels are elevated in oxidative stress conditions. Its levels are positively associated with cardiovascular risk. The aim of this study was to compare serum peroxiredoxin 4 levels between obese subjects with prediabetes and with normal glucose tolerance.
   Methods In this study, we included 80 patients with mean age 50.4 +/- 10.6 years and divided them into two age and BMI-matched groups - group 1 with obesity without glycaemic disturbances (n = 41) and group 2 with obesity and prediabetes (n = 39). Oral glucose tolerance test with measurement of immunoreactive insulin was performed in all participants, and the levels of peroxiredoxin 4 were measured using ELISA method.
   Results We found significantly higher levels of peroxiredoxin 4 in patients with prediabetes compared to controls (2851.2 +/- 4576.6 pg/ml vs 1088.0 +/- 753.3 pg/ml; P = 0.022). There was a mild but statistically significant correlation between peroxiredoxin 4 and weight (r = 0.232; P = 0.038), waist circumference (r = 0.239; P = 0.044), creatinine (r = 0.264; P = 0.019), liver enzymes (ASAT - r = 0.289; P = 0.019 and ALAT - r = 0.305; P = 0.07) and white blood cells count (r = 0.317; P = 0.005). There was no difference in peroxiredoxin 4 levels in patients with and without insulin resistance, as well as with and without metabolic syndrome (MetS), although the levels of peroxiredoxin 4 increased with the number of components of MetS.
   Conclusions The levels of peroxiredoxin 4 are higher in patients with prediabetes, but are similar in subjects with and without insulin resistance, which suggests that the main factor for its increased levels is hyperglycaemia and not insulin sensitivity state.
C1 [Gateva, Antoaneta; Assyov, Yavor; Kamenov, Zdravko] Med Univ, Univ Hosp Alexandrovska, Dept Internal Med, Clin Endocrinol, Sofia, Bulgaria.
   [Velikova, Tsvetelina] Med Univ, Univ Hosp St Ivan Rilski, Dept Clin Lab & Clin Immunol, Clin Immunol Lab, Sofia, Bulgaria.
C3 Medical University Sofia; Medical University Sofia
RP Gateva, A (corresponding author), Med Univ Sofia, Univ Hosp Alexandrovska, Clin Endocrinol, 1 Georgi Sofiiski Str, Sofia 1431, Bulgaria.
EM tony_gateva@yahoo.com
RI Assyov, Yavor/LWI-7733-2024; Gateva, Antoaneta/AGT-4861-2022; Velikova,
   Tsvetelina/H-6932-2019
OI Velikova, Tsvetelina/0000-0002-0593-1272; Assyov,
   Yavor/0000-0002-6195-7346; Kamenov, Zdravko/0000-0002-4829-9449
FU Medical University-Sofia, Medical Sciences Council [5272/30.07.2014/, 2
   - C/2014]
FX The study was conducted with a grant of the Medical University-Sofia,
   Medical Sciences Council - Project 5272/30.07.2014/ Contract 2 - C/2014.
   The sponsor had no role in study design; in the collection, analysis and
   interpretation of data; in the writing of the report; and in the
   decision to submit the article for publication.
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NR 27
TC 8
Z9 8
U1 0
U2 8
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0300-0664
EI 1365-2265
J9 CLIN ENDOCRINOL
JI Clin. Endocrinol.
PD OCT
PY 2016
VL 85
IS 4
BP 551
EP 555
DI 10.1111/cen.13135
PG 5
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA DZ4IH
UT WOS:000385821400006
PM 27303935
DA 2025-06-11
ER

PT J
AU Guleria, RS
   Singh, AB
   Nizamutdinova, IT
   Souslova, T
   Mohammad, AA
   Kendall, JA
   Baker, KM
   Pan, J
AF Guleria, Rakeshwar S.
   Singh, Amar B.
   Nizamutdinova, Irina T.
   Souslova, Tatiana
   Mohammad, Amin A.
   Kendall, Jonathan A., Jr.
   Baker, Kenneth M.
   Pan, Jing
TI Activation of retinoid receptor-mediated signaling ameliorates
   diabetes-induced cardiac dysfunction in Zucker diabetic rats
SO JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
LA English
DT Article
DE Retinoic acid; Retinoid receptor; Diabetic cardiomyopathy; Cardiac
   remodeling; Type 2 diabetes; Zucker diabetic fatty rats
ID NF-KAPPA-B; HYPERGLYCEMIA-INDUCED APOPTOSIS; ANGIOTENSIN-ALDOSTERONE
   SYSTEM; VENTRICULAR DIASTOLIC FUNCTION; FATTY-ACID OXIDATION;
   INSULIN-RESISTANCE; PROTECTS CARDIOMYOCYTES; SUBSTRATE METABOLISM;
   NATRIURETIC PEPTIDE; SKELETAL-MUSCLE
AB Diabetic cardiomyopathy (DCM) is a significant contributor to the morbidity and mortality associated with diabetes and metabolic syndrome. Retinoids, through activation of retinoic acid receptor (RAR) and retinoid x receptor (RXR), have been linked to control glucose and lipid homeostasis, with effects on obesity and diabetes. However, the functional role of RAR and RXR in the development of DCM remains unclear. Zucker diabetic fatty (ZDF) and lean rats were treated with Am580 (RAR alpha agonist) or LGD1069 (RXR agonist) for 16 weeks, and cardiac function and metabolic alterations were determined. Hyperglycemia, hyperlipidemia and insulin resistance were observed in ZDF rats. Diabetic cardiomyopathy was characterized in ZDF rats by increased oxidative stress, apoptosis, fibrosis, inflammation, activation of MAP kinases and NF-kappa B signaling and diminished Akt phosphorylation, along with decreased glucose transport and increased cardiac lipid accumulation, and ultimately diastolic dysfunction. Am580 and LGD1069 attenuated diabetes-induced cardiac dysfunction and the pathological alterations, by improving glucose tolerance and insulin resistance; facilitating Akt activation and glucose utilization, and attenuating oxidative stress and interrelated MAP kinase and NF-kappa B signaling pathways. Am580 inhibited body weight gain, attenuated the increased cardiac fatty acid uptake, beta-oxidation and lipid accumulation in the hearts of ZDF rats. However, LGD1069 promoted body weight gain, hyperlipidemia and cardiac lipid accumulation. In conclusion, our data suggest that activation of RAR and RXR may have therapeutic potential in the treatment of diabetic cardiomyopathy. However, further studies are necessary to clarify the role of RAR and RXR in the regulation of lipid metabolism and homeostasis. (C) 2013 Elsevier Ltd. All rights reserved.
C1 [Guleria, Rakeshwar S.; Singh, Amar B.; Nizamutdinova, Irina T.; Kendall, Jonathan A., Jr.; Baker, Kenneth M.; Pan, Jing] Cent Texas Vet Hlth Care Syst, Texas A&M Hlth Sci Ctr, Coll Med, Div Mol Cardiol,Dept Med, Temple, TX USA.
   [Souslova, Tatiana; Mohammad, Amin A.] Scott & White Mem Hosp & Clin, Dept Pathol, Temple, TX USA.
C3 Texas A&M University System; Texas A&M University College Station; Texas
   A&M Health Science Center; Scott & White Medical Center; Texas A&M
   University System; Texas A&M University College Station; Texas A&M
   Health Science Center
RP Pan, J (corresponding author), Texas A&M Hlth Sci Ctr, Coll Med, Div Mol Cardiol, 1901 South 1st St,Bldg 205, Temple, TX 76504 USA.
EM jpan@medicine.tamhsc.edu
RI pan, jing/KJL-2220-2024; Singh, Amar B/I-2253-2014
OI Singh, Amar B/0000-0002-7677-2424
FU National Institutes of Health [1R01 HL091902]; Scott and White Hospital
   [RGP 100458]
FX This study was supported by a grant from the National Institutes of
   Health (1R01 HL091902) and Scott and White Hospital (RGP 100458). This
   material is the result of work supported with resources and the use of
   facilities at the Central Texas Veterans Health Care System, Temple,
   Texas.
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NR 66
TC 44
Z9 45
U1 0
U2 19
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0022-2828
EI 1095-8584
J9 J MOL CELL CARDIOL
JI J. Mol. Cell. Cardiol.
PD APR
PY 2013
VL 57
BP 106
EP 118
DI 10.1016/j.yjmcc.2013.01.017
PG 13
WC Cardiac & Cardiovascular Systems; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Cell Biology
GA 110EX
UT WOS:000316426500012
PM 23395853
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Palatini, P
   Ceolotto, G
   Ragazzo, F
   Mos, L
   Santonastaso, M
   Zanata, G
   Saladini, F
   Casiglia, E
AF Palatini, P.
   Ceolotto, G.
   Ragazzo, F.
   Mos, L.
   Santonastaso, M.
   Zanata, G.
   Saladini, F.
   Casiglia, E.
CA HARVEST Study Investigators
TI Phosducin rs12402521 polymorphism predicts development of hypertension
   in young subjects with overweight or obesity
SO NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
LA English
DT Article
DE Obesity; Hypertension; Phosducin; Genotype; Genetic
ID AMBULATORY BLOOD-PRESSURE; BETA-GAMMA; METABOLIC SYNDROME; US ADULTS;
   GENE; PREVALENCE; STRESS; ADIPOSITY; COMPLEX; SYSTEM
AB Background and aims: The G-protein regulator phosducin has been shown to be associated with stress-dependent blood pressure, but whether obesity is a modulator of the relationship between phosducin and risk of hypertension is unknown. We studied the effect of two phosducin polymorphisms on risk of hypertension in 273 overweight or obese (Ov-Ob) young-to-middle-age participants from the HARVEST and 287 normal weight (NW) participants.
   Methods and results: Genotyping of phosducin SNPs rs12402521 and rs6672836 was performed by real time PCR. For rs12402521, 64.6% of the participants were homozygous for the G allele, 27.9% heterozygous, and 7.5% homozygous for the A allele. During 7.7 years of follow-up, 339 subjects developed hypertension. In a Cox multivariable model, carriers of the A allele had a 1.28 (95% CI, 1.00-1.63, p = 0.046) increased risk of hypertension. However, increased incidence of hypertension associated with A allele (AA + AG, 79% and GG, 59%, p = 0.001) was observed only among Ov-Ob individuals with a hazard ratio of 1.60 (95% CI, 1.13-2.21, p = 0.007) whereas in NW subjects the incidence of hypertension did not differ by genotype (56% in both groups). In the whole cohort, there was a significant interaction of phosducin genotype with body mass index on the risk of hypertension (p = 0.012). For SNP rs6672836 no association was found with incident hypertension. No haplotype effect was detected on the risk of hypertension.
   Conclusion: These data suggest that phosducin rs12402521 polymorphism is an important genetic predictor of obesity-related hypertension. In Ov-Ob carriers of the A allele aggressive nonpharmacological measures should be implemented. (C) 2011 Elsevier B.V. All rights reserved.
C1 [Palatini, P.; Ceolotto, G.; Ragazzo, F.; Saladini, F.; Casiglia, E.] Univ Padua, Dept Clin & Expt Med, I-35128 Padua, Italy.
   [Mos, L.] Town Hosp, San Daniele Del Friuli, Italy.
   [Santonastaso, M.] Town Hosp, Vittorio Veneto, Italy.
   [Zanata, G.] Town Hosp, Pordenone, Italy.
C3 University of Padua
RP Palatini, P (corresponding author), Univ Padua, Dept Clin & Expt Med, Via Giustiniani 2, I-35128 Padua, Italy.
EM palatini@unipd.it
OI Ceolotto, Giulio/0000-0002-4687-8033; SALADINI,
   Francesca/0000-0003-1846-4738
FU University of Padova, Padova, Italy; Associazione "18 Maggio 1370", San
   Daniele del Friuli, Italy
FX The study was funded by the University of Padova, Padova, Italy, and
   from the Associazione "18 Maggio 1370", San Daniele del Friuli, Italy.
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NR 36
TC 2
Z9 4
U1 0
U2 8
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0939-4753
EI 1590-3729
J9 NUTR METAB CARDIOVAS
JI Nutr. Metab. Carbiovasc. Dis.
PD APR
PY 2013
VL 23
IS 4
BP 323
EP 329
DI 10.1016/j.numecd.2011.08.004
PG 7
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism; Nutrition
   & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism;
   Nutrition & Dietetics
GA 114SS
UT WOS:000316763400007
PM 22365573
DA 2025-06-11
ER

PT J
AU Tinahones, FJ
   Cardona, F
   Rojo-Martínez, G
   Almaraz, AC
   Cardona, I
   Vázquez-Mellado, J
   Garrido-Sánchez, L
   Collantes, E
   Soriguer, F
AF Tinahones, F. J.
   Cardona, F.
   Rojo-Martinez, G.
   Almaraz, A. C.
   Cardona, I.
   Vazquez-Mellado, J.
   Garrido-Sanchez, L.
   Collantes, E.
   Soriguer, F.
TI Decreased levels of uric acid after oral glucose challenge is associated
   with triacylglycerol levels and degree of insulin resistance
SO BRITISH JOURNAL OF NUTRITION
LA English
DT Article
DE uric acid; insulin resistance; OGTT; triacylglycerol
ID INDUCED OXIDATIVE STRESS; TYPE-2 DIABETIC-PATIENTS; CIII-AIV CLUSTER;
   CARDIOVASCULAR-DISEASE; ENDOTHELIAL DYSFUNCTION; RENAL EXCRETION;
   TOLERANCE TEST; PLASMA; HYPERURICEMIA; COMPLICATIONS
AB Hyperuricaemia is one of the components of metabolic syndrome. Both oxidative stress and hyperinsulinism are important variables in the genesis of this syndrome and have a close association with uric acid (UA). We evaluated the effect of an oral glucose challenge on UA concentrations. The study included 656 persons aged 18 to 65 years. Glycaemia, insulin, UA and plasma proteins were measured at baseline and 120 min after an oral glucose tolerance test (OGTT). The baseline sample also included measurements of total cholesterol, triacylglycerol (TAG) and HDL-cholesterol. Insulin resistance was calculated with the homeostasis model assessment. UA levels were significantly lower after the OGTT (281-93 (So 92.19) v. 267-48 (SD 90-40) mu mol/l; P<0.0001). Subjects with a drop in UA concentrations >40-86 mu mol/l (> 75th percentile) had higher plasma TAG levels (P=0-0001), baseline insulin (P=0.02) and greater insulin resistance (P=0-034). Women with a difference in plasma concentrations of UA above the 75th percentile had higher baseline insulin levels (P=0.019), concentration of plasma TAG (P=0.0001) and a greater insulin resistance index (P=0-029), whereas the only significant difference in men was the level of TAG. Multiple regression analysis showed that the basal TAG levels, insulin at 120min, glycaemia at 120min and waist:hip ratio significantly predicted the variance in the UA difference (r(2) 0.077). Levels of UA were significantly lower after the OGTT and the individuals with the greatest decrease in UA levels are those who have greater insulin resistance and higher TAG levels.
C1 [Tinahones, F. J.; Cardona, F.] Hosp Clin Univ Virgen Victoria, Serv Endocrinol & Nutr, Malaga, Spain.
   [Tinahones, F. J.; Cardona, F.] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr CB06 03, Malaga, Spain.
   [Rojo-Martinez, G.; Cardona, I.; Garrido-Sanchez, L.] Fundac IMABIS, Inst Mediaterraneo Avance Biotecnol & Invest Sani, Malaga, Spain.
   [Almaraz, A. C.; Soriguer, F.] Hosp Reg Univ Carlos Haya, Serv Endocrinol & Nutr, Malaga, Spain.
   [Vazquez-Mellado, J.] Hosp Gen Ciudad Mexico, Mexico City, DF, Mexico.
   [Collantes, E.] Hosp Univ Reina Sofia Cordoba, Serv Reumatol, Cordoba, Spain.
C3 Hospital Virgen de la Victoria; CIBER - Centro de Investigacion
   Biomedica en Red; CIBEROBN; Instituto de Salud Carlos III; FIMABIS;
   Hospital Carlos Haya; Hospital Universitario Reina Sofia - Cordoba
RP Tinahones, FJ (corresponding author), Hosp Clin Univ Virgen Victoria, Serv Endocrinol & Nutr, Malaga, Spain.
EM fjtinahones@terra.es
RI Cardona, Fernando/AAG-7835-2019; Collantes-Estevez, Eduardo/M-9549-2019;
   Tinahones, Francisco/AAB-2882-2020; Rojo-Martinez, Gemma/E-3351-2010;
   Cardona, Fernando/H-6022-2015
OI Almaraz, Maria Cruz/0000-0002-4470-4515; Rojo-Martinez,
   Gemma/0000-0003-2179-2134; Collantes Estevez,
   Eduardo/0000-0002-7647-6289; Tinahones, Francisco J/0000-0001-6871-4403;
   Cardona, Fernando/0000-0003-4460-6824
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NR 36
TC 9
Z9 10
U1 0
U2 5
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1145
EI 1475-2662
J9 BRIT J NUTR
JI Br. J. Nutr.
PD JAN
PY 2008
VL 99
IS 1
BP 44
EP 48
DI 10.1017/S0007114507787470
PG 5
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 262TM
UT WOS:000253170900006
PM 17761018
OA Bronze
DA 2025-06-11
ER

PT J
AU Noorbakhsh, S
   Roshan, VD
AF Noorbakhsh, Sepideh
   Roshan, Valiollah Dabidi
TI Influence of 8 Weeks of Tabata High-Intensity Interval Training and
   Nanocurcumin Supplementation on Inflammation and Cardiorespiratory
   Health among Overweight Elderly Women
SO PREVENTIVE NUTRITION AND FOOD SCIENCE
LA English
DT Article
DE high intensity interval training; inflammasome; metabolic syndrome;
   myocardial infarction associated transcript; nanocurcumin
ID INSULIN-RESISTANCE; CURCUMIN; BIOAVAILABILITY; OBESITY
AB Nanocurcumin (NaC) and high-intensity interval training (HIIT) play crucial role in weight and inflammation control. The purpose of the current study was to evaluate the separate and combined effects of 8 weeks of Tabata-HIIT and NaC supplementation on the NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome, long non-coding RNA myocardial infarction associated transcript (lncRNA MIAT) expression, body composition, and cardiorespiratory health in elderly overweight women. A total of 48 healthy overweight elderly women were randomly divided into four groups: NaC, Tabata-HIIT+Pla, Tabata-HIIT+NaC, and placebo. Participants underwent a Tabata HIIT program (2 days per week, at 80 similar to 0% of maximal HR) and NaC supplementation (daily 80 mg in two 40 mg capsules) for 8 weeks. Blood sampling, cardiorespiratory hemodynamic responses, and body composition evaluations were obtained before and after treadmill stress testing at the baseline timepoint and following 8 weeks of intervention. The mRNA of lncRNA-MIAT and NLRP3 were measured by real-time polymerase chain reaction. After 8 weeks, a significant improvement was observed in body composition and cardiorespiratory hemodynamics in the Tabata-HIIT groups compared to the NaC alone and placebo groups (P<0.05). Tabata training, both with and without the addition of nano curcumin supplementation, did not result significant effect on the resting levels of lncRNA-MIAT expression (P>0.05). Nevertheless, NaC supplementation along with Tabata training led to a significant reduction in NLRP3 inflammasome. In addition, NaC supplementation in overweight/pre-obese women improved systemic inflammation during treadmill stress testing. These findings indicating the suppressive effects of non-pharmacologic interventions on the sympathetic system and downregulation of the inflammasome.
C1 [Noorbakhsh, Sepideh; Roshan, Valiollah Dabidi] Univ Mazandaran, Dept Exercise Physiol, Babolsar 416, Iran.
   [Roshan, Valiollah Dabidi] Univ Mazandaran, Athlet Performance & Hlth Res Ctr, Dept Exercise Physiol, Fac Sport Sci, Babolsar 416, Iran.
C3 University of Mazandaran; University of Mazandaran
RP Roshan, VD (corresponding author), Univ Mazandaran, Dept Exercise Physiol, Babolsar 416, Iran.; Roshan, VD (corresponding author), Univ Mazandaran, Athlet Performance & Hlth Res Ctr, Dept Exercise Physiol, Fac Sport Sci, Babolsar 416, Iran.
EM v.dabidi@umz.ac.ir
RI roshan, valiollah/AAE-8706-2021
OI Dabidi Roshan, Valiollah/0000-0002-2202-7349; noorbakhsh,
   sepideh/0000-0002-1894-6094
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NR 40
TC 2
Z9 2
U1 2
U2 10
PU KOREAN SOC FOOD SCIENCE NUTRITION
PI BUSAN
PA 1010, 993, JUNGANG-DAERO, BUSANJIN-GU, BUSAN, 47209, SOUTH KOREA
SN 2287-1098
EI 2287-8602
J9 PREV NUTR FOOD SCI
JI Prev. Nutr. Food Sci.
PD SEP
PY 2023
VL 28
IS 3
BP 224
EP 234
DI 10.3746/pnf.2023.28.3.224
PG 11
WC Food Science & Technology; Nutrition & Dietetics
WE Emerging Sources Citation Index (ESCI)
SC Food Science & Technology; Nutrition & Dietetics
GA X7XD1
UT WOS:001100524000002
PM 37842247
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Rodriguez-López, LA
   Torre-Villalvazo, I
   Aleman-Escondrillas, G
   Flores-López, A
   Guevara-Cruz, M
   Sánchez-Tapia, M
   Torre-Anaya, EA
   Martínez-López, V
   Vasquez-Reyes, S
   Torres-Villalobos, GM
   Macotela, Y
   Torres, N
   Tovar, AR
AF Rodriguez-Lopez, Leonardo A.
   Torre-Villalvazo, Ivan
   Aleman-Escondrillas, Gabriela
   Flores-Lopez, Adriana
   Guevara-Cruz, Martha
   Sanchez-Tapia, Monica
   Torre-Anaya, Erik A.
   Martinez-Lopez, Valentin
   Vasquez-Reyes, Sarai
   Torres-Villalobos, Gonzalo M.
   Macotela, Yazmin
   Torres, Nimbe
   Tovar, Armando R.
TI The capacity of differentiation of stromal vascular fraction cells into
   beige adipocytes is markedly reduced in subjects with overweight/obesity
   and insulin resistance: effect of genistein
SO INTERNATIONAL JOURNAL OF OBESITY
LA English
DT Article
ID ENDOPLASMIC-RETICULUM STRESS; WHITE ADIPOSE-TISSUE; RESVERATROL
   SUPPLEMENTATION; STEM-CELLS; METABOLIC SYNDROME; LINKING OBESITY; FAT;
   BROWN; GLUCOSE; THERMOGENESIS
AB Background Dietary bioactive compounds have been demonstrated to produce several health benefits. Genistein, an isoflavone of soy protein, and resveratrol, a polyphenol from grapes, have been shown to improve insulin sensitivity and to stimulate white adipose tissue (WAT) browning, leading to increased energy expenditure. However, it has not been demonstrated in humans whether genistein or resveratrol have the capacity to stimulate the differentiation of stromal vascular fraction (SVF) cells from white fat into beige adipocytes. Subjects/methods With this aim, we assessed whether stromal vascular fraction cells obtained from biopsies of the subdermal fat depots of subjects with normal body weight (NW) or from subjects with overweight/obesity with (OIR) or without (OIS) insulin resistance were able to differentiate into the beige adipose tissue lineage in vitro, by exposing the cells to genistein, resveratrol, or the combination of both. Results The results showed that SVF cells obtained from NW or OIS subjects were able to differentiate into beige adipocytes according to an increased expression of beige biomarkers including UCP1, PDRM-16, PGC1 alpha, CIDEA, and SHOX2 upon exposure to genistein. However, SVF cells from OIR subjects were unable to differentiate into beige adipocytes with any of the inducers. Exposure to resveratrol or the combination of resveratrol/genistein did not significantly stimulate the expression of browning markers in any of the groups studied. We found that the non-responsiveness of the SVF from subjects with obesity and insulin resistance to any of the inducers was associated with an increase in the expression of endoplasmic reticulum stress markers. Conclusion Consumption of genistein may stimulate WAT browning mainly in NW or OIS subjects. Thus, obesity associated with insulin resistance may be considered as a condition that prevents some beneficial effects of some dietary bioactive compounds.
C1 [Rodriguez-Lopez, Leonardo A.; Torre-Villalvazo, Ivan; Aleman-Escondrillas, Gabriela; Flores-Lopez, Adriana; Guevara-Cruz, Martha; Sanchez-Tapia, Monica; Torre-Anaya, Erik A.; Vasquez-Reyes, Sarai; Torres, Nimbe; Tovar, Armando R.] Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Physiol Nutr, Mexico Cdmx, Mexico.
   [Martinez-Lopez, Valentin] Inst Nacl Rehabil Luis Guillermo Ibarra Ibarra, Tissue Engn Cell Therapy & Regenerat Med Unit, Mexico Cdmx, Mexico.
   [Torres-Villalobos, Gonzalo M.] Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Expt Surg, Mexico Cdmx, Mexico.
   [Macotela, Yazmin] Univ Nacl Autonoma Mexico, Inst Neurobiol, Juriquilla, Mexico.
C3 Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran -
   Mexico; Instituto Nacional de Ciencias Medicas y Nutricion Salvador
   Zubiran - Mexico; Universidad Nacional Autonoma de Mexico
RP Tovar, AR (corresponding author), Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Physiol Nutr, Mexico Cdmx, Mexico.
EM Armando.tovarp@incmnsz.mx
RI SANCHEZ-TAPIA, MONICA/JDV-7490-2023; ALEMAN, GABRIELA/AAB-6484-2020;
   Torres, Nimbe/AAY-8821-2020; Martinez-Lopez, Valentin/O-7487-2017;
   Torre-Villalvazo, Ivan/M-2497-2014
OI Martinez-Lopez, Valentin/0000-0001-9607-4327; Torre-Villalvazo,
   Ivan/0000-0001-7412-1153; Rodriguez Lopez, Leonardo
   Alejandro/0000-0001-8173-9314; Aleman, Gabriela/0000-0003-0755-2302;
   Torre Anaya, Erik Alejandro/0000-0002-5911-8527; Sanchez-Tapia,
   Monica/0000-0001-9748-5734
FU National Council of Science and Technology Mexico (CONACYT) [261843];
   National Institute of Medical Sciences and Nutrition S.Z
FX This work was supported by the National Council of Science and
   Technology Mexico (CONACYT) (Grant Number 261843 to ART) and supported
   by the National Institute of Medical Sciences and Nutrition S.Z.
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NR 66
TC 8
Z9 8
U1 0
U2 7
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0307-0565
EI 1476-5497
J9 INT J OBESITY
JI Int. J. Obes.
PD NOV
PY 2021
VL 45
IS 11
BP 2471
EP 2481
DI 10.1038/s41366-021-00921-3
EA JUL 2021
PG 11
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA WJ9OM
UT WOS:000680572300003
PM 34331001
DA 2025-06-11
ER

PT J
AU Kaplan, A
   Abidi, E
   Habeichi, NJ
   Ghali, R
   Alawasi, H
   Fakih, C
   Zibara, K
   Kobeissy, F
   Husari, A
   Booz, GW
   Zouein, FA
AF Kaplan, Abdullah
   Abidi, Emna
   Habeichi, Nada J.
   Ghali, Rana
   Alawasi, Hiam
   Fakih, Christina
   Zibara, Kazem
   Kobeissy, Firas
   Husari, Ahmad
   Booz, George W.
   Zouein, Fouad A.
TI Gender-biased kidney damage in mice following exposure to tobacco
   cigarette smoke: More protection in premenopausal females
SO PHYSIOLOGICAL REPORTS
LA English
DT Article
DE cigarette smoking; gender differences; inflammation; kidney damage;
   oxidative stress
ID GLOMERULAR-FILTRATION-RATE; INDUCED PULMONARY INFLAMMATION; ALL-CAUSE
   MORTALITY; OXIDATIVE STRESS; METABOLIC SYNDROME; RENAL INJURY;
   RISK-FACTORS; PROSPECTIVE COHORT; ENDOTHELIAL-CELLS; SECONDHAND SMOKE
AB Multiple clinical studies documented renal damage in chronic cigarette smokers (CS) irrespective of their age and gender. Premenopausal female smokers are known to exert a certain cardiovascular and renal protection with undefined mechanisms. Given the multiple demographic variables within clinical studies, this experimental study was designed to be the first to assess whether gender-biased CS-induced kidney damage truly exists between premenopausal female and age-matched C57Bl6J male mice when compared to their relative control groups. Following 6 weeks of CS exposure, cardiac function, inflammatory marker production, fibrosis formation, total and glomerular ROS levels, and glomerulotubular homeostasis were assessed in both genders. Although both CS-exposed male and female mice exhibited comparable ROS fold change relative to their respective control groups, CS-exposed male mice showed a more pronounced fibrotic deposition, inflammation, and glomerulotubular damage profile. However, the protection observed in CS-exposed female group was not absolute. CS-exposed female mice exhibited a significant increase in fibrosis, ROS production, and glomerulotubular alteration but with a pronounced anti-inflammatory profile when compared to their relative control groups. Although both CS-exposed genders presented with altered glomerulotubular homeostasis, the alteration phenotype between genders was different. CS-exposed males showed a significant decrease in Bowman's space along with reduced tubular diameter consistent with an endocrinization pattern of chronic tubular atrophy, suggestive of an advanced stage of glomerulotubular damage. CS-exposed female group, on the other hand, displayed glomerular hypertrophy with a mild tubular dilatation profile suggestive of an early stage of glomerulotubular damage that generally precedes collapse. In conclusion, both genders are prone to CS-induced kidney damage with pronounced female protection due to a milder damage slope.
C1 [Kaplan, Abdullah; Abidi, Emna; Habeichi, Nada J.; Ghali, Rana; Alawasi, Hiam; Zouein, Fouad A.] Amer Univ Beirut, Dept Pharmacol & Toxicol, Fac Med, Beirut, Lebanon.
   [Fakih, Christina; Zibara, Kazem] Lebanese Univ, Fac Sci 1, Biol Dept, Beirut, Lebanon.
   [Kobeissy, Firas] Amer Univ Beirut, Dept Biochem & Mol Genet, Fac Med, Beirut, Lebanon.
   [Husari, Ahmad] Amer Univ Beirut, Dept Internal Med Resp Dis & Sleep Med, Med Ctr, Beirut, Lebanon.
   [Booz, George W.] Univ Mississippi, Med Ctr, Dept Pharmacol & Toxicol, Jackson, MS 39216 USA.
C3 American University of Beirut; Lebanese University; American University
   of Beirut; American University of Beirut; University of Mississippi
   Medical Center; University of Mississippi
RP Zouein, FA (corresponding author), Amer Univ Beirut, Dept Pharmacol & Toxicol, Beirut 11072020, Lebanon.; Husari, A; Zouein, FA (corresponding author), Med Ctr, Beirut 11072020, Lebanon.; Husari, A (corresponding author), Amer Univ Beirut, Dept Internal Med, Beirut 11072020, Lebanon.
EM ah51@aub.edu.lb; fouadzouein@outlook.com
RI husari, ahmad/AAD-5200-2022; Kobeissy, Firas/E-7042-2017
OI Kobeissy, Firas/0000-0002-5008-6944; abidi, emna/0000-0002-6054-1840;
   Zouein, Fouad/0000-0003-4451-804X; Zibara, Kazem/0000-0002-9887-072X;
   kaplan, abdullah/0000-0001-5001-6199
FU Centre National de la Recherche Scientifique (CNRS) [103507/103487,
   100410]
FX This work was funded to FAZ by Centre National de la Recherche
   Scientifique (CNRS) #103507/103487 and Seed grant #100410.
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NR 142
TC 6
Z9 7
U1 0
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2051-817X
J9 PHYSIOL REP
JI PHYSIOL. REP.
PD JAN
PY 2020
VL 8
IS 2
AR e14339
DI 10.14814/phy2.14339
PG 17
WC Physiology
WE Emerging Sources Citation Index (ESCI)
SC Physiology
GA MY4DB
UT WOS:000558368000008
PM 31981316
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Xia, HM
   Wang, J
   Xie, XJ
   Xu, LJ
   Tang, SQ
AF Xia, Hong-Miao
   Wang, Jin
   Xie, Xiao-Jie
   Xu, Li-Juan
   Tang, Shi-Qi
TI Green tea polyphenols attenuate hepatic steatosis, and reduce insulin
   resistance and inflammation in high-fat diet-induced rats
SO INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
LA English
DT Article
DE hepatic steatosis; insulin resistance; inflammation; adenosine
   monophosphate kinase; non-alcoholic fatty liver disease
ID LIVER-DISEASE; OXIDATIVE STRESS; FIBROSIS; LIPOGENESIS; INHIBITION;
   DIAGNOSIS
AB Non-alcoholic fatty liver disease (NAFLD) is characterized by hepatic steatosis, insulin resistance and inflammation; however, the exact pathogenesis of NAFLD is not fully understood. Green tea polyphenols (GTP) exhibit beneficial effects against metabolic syndrome. However, the effect of GTP on NAFLD remains largely unknown. The aim of the present study was to investigate the effects of GTP on NAFLD in high-fat diet (HFD)-induced rats. The NAFLD rat model was induced with a HFD for 8 weeks. A total of 30 adult male Sprague Dawley rats were randomly divided into three groups: i) Normal control group; ii) HFD group; and iii) HFD with GTP group. Hematoxylin and eosin and Oil Red O analyses were performed. The levels of alanine aminotransferase (ALT), aspartate amino transferase (AST) and inflammatory cytokines in the serum, as well as oxidative stress markers and hepatic lipids in the liver were measured. In addition, parameters associated with glucose metabolism were also assessed. Western blotting and RT-qPCR were used to determine the expression levels of 5 ' adenosine monophosphate-activated protein kinase (AMPK). HFD-induced rats exhibited features associated with NAFLD. GTP intervention significantly reduced serum ALT and AST levels. Fasting serum glucose, insulin resistance and hepatic lipid levels were all decreased in the GTP-treated rats. GTP also significantly decreased the levels of TNF-alpha, IL-6 and malondialdehyde. In contrast, superoxide dismutase levels were increased in the liver. Furthermore, GTP also significantly increased phosphorylation of AMPK and attenuated histopathological changes indicative of injury in liver tissue. GTP has a protective effect on HFD-induced hepatic steatosis, insulin resistance and inflammation, and the underlying mechanism may involve the AMPK pathway.
C1 [Xia, Hong-Miao; Wang, Jin; Xie, Xiao-Jie; Xu, Li-Juan; Tang, Shi-Qi] Wuhan Univ, Renmin Hosp, Med Examinat Ctr, 99 Zhang Zhidong Rd, Wuhan 430060, Hubei, Peoples R China.
   [Xia, Hong-Miao] Wuhan Univ, Renmin Hosp, Hubei Key Lab Digest Syst Dis, Wuhan 430060, Hubei, Peoples R China.
C3 Wuhan University; Wuhan University
RP Tang, SQ (corresponding author), Wuhan Univ, Renmin Hosp, Med Examinat Ctr, 99 Zhang Zhidong Rd, Wuhan 430060, Hubei, Peoples R China.
EM wh88063953@qq.com
RI Tang, Shi/GXH-5719-2022
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NR 38
TC 40
Z9 46
U1 1
U2 46
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1107-3756
EI 1791-244X
J9 INT J MOL MED
JI Int. J. Mol. Med.
PD OCT
PY 2019
VL 44
IS 4
BP 1523
EP 1530
DI 10.3892/ijmm.2019.4285
PG 8
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA IZ4XH
UT WOS:000487086000031
PM 31364723
OA Bronze
DA 2025-06-11
ER

PT J
AU Yamazato, R
   Yamamoto, H
   Tadehara, F
   Teragawa, H
   Kurisu, S
   Dohi, Y
   Ishibashi, K
   Kunita, E
   Utsunomiya, H
   Oka, T
   Kihara, Y
AF Yamazato, Ryo
   Yamamoto, Hideya
   Tadehara, Futoshi
   Teragawa, Hiroki
   Kurisu, Satoshi
   Dohi, Yoshihiro
   Ishibashi, Ken
   Kunita, Eiji
   Utsunomiya, Hiroto
   Oka, Toshiharu
   Kihara, Yasulci
TI Association Between Aortic Valve Calcification and Myocardial Ischemia,
   Especially in Asymptomatic Patients
SO JOURNAL OF NUCLEAR MEDICINE
LA English
DT Article
DE aortic valve calcification; myocardial ischemia; SPECT; asymptomatic
ID EMISSION COMPUTED-TOMOGRAPHY; CORONARY-ARTERY-DISEASE; METABOLIC
   SYNDROME; MEDICAL THERAPY; EARLY LESION; SCLEROSIS; PERFUSION; STENOSIS;
   PROGRESSION; CALCIUM
AB Aortic valve calcification (AVC) is recognized as a manifestation of systemic arteriosclerosis. However, it is unclear whether AVC is associated with myocardial ischemia. Stress myocardial perfusion SPECT (MPS) is widely used for the diagnosis of myocardial ischemia. However, routine MPS is not recommended, particularly in asymptomatic patients. Accordingly, we investigated the hypothesis that the presence of AVC is strongly associated with inducible myocardial ischemia, even among asymptomatic patients. Methods: We investigated 669 consecutive patients who underwent both adenosine stress (TI)-T-201 MPS and echocardiography. We evaluated the extent and severity of myocardial ischemia by the summed difference score (SDS). We defined the presence of myocardial ischemia as SDS >= 3 and moderate to severe ischemia as SDS >= 8. We classified the severity of AVC according to the number of affected aortic leaflets. We also compared the mean SDS and the prevalence of SDS >= 3 and SDS >= 8 among patients stratified by the severity of AVC. Results: The presence of AVC was significantly associated with myocardial ischemia (odds ratio [OR], 1.56; 95% confidence interval [CI], 1.10-2.23; P = 0.013) and moderate to severe ischemia (OR, 2.16; 95% CI, 1.26-3.80; P = 0.0061). In 311 asymptomatic patients, AVC was strongly associated with moderate to severe ischemia (OR, 4.31; 95% CI, 1.67-12.8; P = 0.0043). However, the SDS value and the prevalence of SDS >= 3 and SDS >= 8 did not increase with increasing number of affected aortic leaflets. Conclusion: The presence of AVC may be associated with the presence of myocardial ischemia, particularly in asymptomatic patients. However, we found no association between the extent of AVC and inducible myocardial ischemia. The presence of AVC may be a useful anatomic marker to help identify patients at high risk of myocardial ischemia, particularly asymptomatic patients.
C1 [Yamazato, Ryo; Yamamoto, Hideya; Tadehara, Futoshi; Teragawa, Hiroki; Kurisu, Satoshi; Dohi, Yoshihiro; Ishibashi, Ken; Kunita, Eiji; Utsunomiya, Hiroto; Oka, Toshiharu; Kihara, Yasulci] Hiroshima Univ, Dept Cardiovasc Med, Grad Sch Biomed Sci, Hiroshima 7348551, Japan.
C3 Hiroshima University
RP Yamamoto, H (corresponding author), Hiroshima Univ, Dept Cardiovasc Med, Grad Sch Biomed Sci, 1-2-3 Kasumi Minami Ku, Hiroshima 7348551, Japan.
EM hideyayama@hiroshima-u.ac.jp
RI Teragawa, Hiroki/AAJ-5116-2020
FU Grants-in-Aid for Scientific Research [23591044] Funding Source: KAKEN
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NR 31
TC 14
Z9 15
U1 0
U2 0
PU SOC NUCLEAR MEDICINE INC
PI RESTON
PA 1850 SAMUEL MORSE DR, RESTON, VA 20190-5316 USA
SN 0161-5505
J9 J NUCL MED
JI J. Nucl. Med.
PD AUG
PY 2012
VL 53
IS 8
BP 1216
EP 1221
DI 10.2967/jnumed.111.099275
PG 6
WC Radiology, Nuclear Medicine & Medical Imaging
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Radiology, Nuclear Medicine & Medical Imaging
GA 984OT
UT WOS:000307201300022
PM 22855836
OA Bronze
DA 2025-06-11
ER

PT J
AU Riechelmann-Casarin, L
   Valente, LC
   Otton, R
   Barbisan, LF
   Romualdo, GR
AF Riechelmann-Casarin, Luana
   Valente, Leticia Cardoso
   Otton, Rosemari
   Barbisan, Luis Fernando
   Romualdo, Guilherme Ribeiro
TI Are glyphosate or glyphosate-based herbicides linked to metabolic
   dysfunction-associated steatotic liver disease (MASLD)? The weight of
   current evidence
SO ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
LA English
DT Article
DE Glyphosate; Herbicide; Non-alcoholic fatty liver disease; Metabolic
   dysfunction-associated steatotic liver; disease
ID TERM-FOLLOW-UP; NONALCOHOLIC STEATOHEPATITIS; HEPATOCELLULAR-CARCINOMA;
   COMMERCIAL FORMULATION; OXIDATIVE STRESS; YIELD LOSSES; EXPOSURE; CROPS;
   WEEDS; NAFLD
AB Metabolic dysfunction-associated steatotic liver disease (MASLD) affects around 30 % of the world's population, increasing its prevalence by 50 % in the last three decades. MASLD pathogenesis is considered multiaxial, involving disturbances in the liver, adipose tissue (AT), and gut microbiome. In parallel with MASLD increasing trends, the total herbicide use has nearly tripled over the last three decades. Glyphosate (GLY) is the most used herbicide worldwide (825 mi kg/year). The intensive use of GLY-based herbicides (GBH) - largely driven by the adoption of glyphosate-tolerant genetically modified crops over the past two decades - has led to environmental (soil and water) and food contamination, resulting in continuous human exposure. Emerging (pre)clinical data highlights the significant implications of this herbicide on MASLD, marking a critical research area. Thus, this narrative review paper aimed at gathering and evaluating all epidemiological and (pre)clinical data on the implications of GLY or GBH on MASLD outcomes. Our work encompassed literature published between 2008-2025. Human urinary GLY levels are associated with different MASLD outcomes (steatosis risk, advanced fibrosis, increased transaminases) and comorbidities (higher risk for metabolic syndrome, diabetes, obesity and cardiovascular diseases) (6 studies). In vitro data indicate that GBH/GLY cause oxidative stress, genomic instability, apoptosis, and membrane disruption in hepatocytes, while promoting apoptosis and lipid peroxidation in (pre)adipocytes and cytokine production in monocytes (15 studies). In rodent studies (21 studies), GLY/GBH - in doses based on human exposure/toxicological limits - induces inflammatory and oxidative responses in the liver and AT, while causing dysbiosis and metabolic alterations in the gut microbiome axis. In the light of populational-, cell-and animal-based evidence, GLY/GBH disturbs key axis of MASLD pathogenesis and is pothesized to be associated with its clinical outcomes.
C1 [Riechelmann-Casarin, Luana; Valente, Leticia Cardoso; Romualdo, Guilherme Ribeiro] Sao Paulo State Univ UNESP, Botucatu Med Sch, Expt Res Unit UNIPEX, Ave Prof Mario Rubens Guimaraes Montenegro S-N Rub, BR-18618687 Botucatu, SP, Brazil.
   [Otton, Rosemari] Univ Cruzeiro Sul, Interdisciplinary Postgrad Program Hlth Sci, Sao Paulo, Brazil.
   [Barbisan, Luis Fernando] Sao Paulo State Univ UNESP, Botucatu Biosci Inst, Dept Struct & Funct Biol, Botucatu, Brazil.
C3 Universidade Estadual Paulista; Universidade Cruzeiro do Sul;
   Universidade Estadual Paulista
RP Romualdo, GR (corresponding author), Sao Paulo State Univ UNESP, Botucatu Med Sch, Expt Res Unit UNIPEX, Ave Prof Mario Rubens Guimaraes Montenegro S-N Rub, BR-18618687 Botucatu, SP, Brazil.
EM guilherme.romualdo@unesp.br
RI Romualdo, Guilherme/AAB-4306-2020; Barbisan, Luis/AAX-8402-2021
FU Sao Paulo Research Foundation (FAPESP) [22/06082-8, 23/08751-7]; FAPESP
   scholarships [23/17585-3, 23/05411-0]; National Council for Scientific
   and Technological Development (CNPq) [306918/2021-8, 302986/2021-9]
FX Guilherme R. Romualdo is the recipient of a grant and scholarship from
   Sao Paulo Research Foundation (FAPESP) (22/06082-8 and 23/08751-7) .
   Luana Riechelmann-Casarin and Leticia C. Valente are also recipients of
   FAPESP scholarships (23/17585-3 and 23/05411-0, respectively) . Luis F.
   Barbisan and Rosemari Otton were the recipients of support research from
   the National Council for Scientific and Technological Development (CNPq,
   #306918/2021-8 and #302986/2021-9, respectively) . The funders did not
   influence the writing and interpretation of data.
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NR 126
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1382-6689
EI 1872-7077
J9 ENVIRON TOXICOL PHAR
JI Environ. Toxicol. Pharmacol.
PD JUN
PY 2025
VL 116
AR 104705
DI 10.1016/j.etap.2025.104705
PG 21
WC Environmental Sciences; Pharmacology & Pharmacy; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Pharmacology & Pharmacy; Toxicology
GA 2PE8C
UT WOS:001488006500002
PM 40311787
DA 2025-06-11
ER

PT J
AU Machulsky, NF
   Gagliardi, J
   Fabre, B
   Miksztowicz, V
   Lombardo, M
   Escudero, AG
   Gigena, G
   Blanco, F
   Gelpi, RJ
   Schreier, L
   Gidron, Y
   Berg, G
AF Fernandez Machulsky, Nahuel
   Gagliardi, Juan
   Fabre, Bibiana
   Miksztowicz, Veronica
   Lombardo, Micaela
   Garcia Escudero, Alejandro
   Gigena, Gerardo
   Blanco, Federico
   Gelpi, Ricardo J.
   Schreier, Laura
   Gidron, Yori
   Berg, Gabriela
TI Matrix metalloproteinases and psychosocial factors in acute coronary
   syndrome patients
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE Metalloproteinase; Acute coronary syndrome; Social support; Hostility
ID ACUTE MYOCARDIAL-INFARCTION; SOCIAL SUPPORT; LIFE EVENTS;
   CARDIOVASCULAR-DISEASE; PSYCHOLOGICAL-FACTORS; DEPRESSIVE SYMPTOMS;
   METABOLIC SYNDROME; RISK-FACTORS; NO HISTORY; HOSTILITY
AB Psychosocial factors have been linked to cardiovascular diseases independently of traditional risk factors. The impact of psychosocial factors on plaque destabilizing factors, such as matrix metalloproteinases (MMPs) has been proposed although scarcely studied.
   Objective: To evaluate the relationships between hostility, perceived stress and social support with MMPs activity in patients after an Acute Myocardial Infarction (AMI).
   Methods: Blood samples were obtained from 76 patients on admission, post-angioplasty, 24 h, 7 days and 3 months after AMI. Hostility, perceived stress and social support were evaluated by validated questionnaires.
   Results: Social support was positively correlated with patientsi ejection fraction (r=0.453, p=0.009). Patients with higher infarct size presented increased MMP-2 activity at admission (p=0.04). Patients with one diseased vessel had more social support than those with three diseased vessels (p=0.05). The highest values of MMP-2 and MMP-9 activity were observed at the acute event, decreasing, with the lowest activity at 3 months post-AMI (p<0.001). Only in patients with low social support, hostility correlated with MMP-2 activity, from AMI onset (r=0.645, p = 0.013), to 7 days post AMI (r = 0.557, p = 0.038). Hostility explained up to 28% of the variance in MMP-2 activity (R-2 = 0.28, p = 0.005). Finally, in patients with high hostility, MMP-9 was positively correlated with IL-1 beta (r=0.468, p=0.02).
   Conclusions: This study adds weight to the idea that two psychosocial factors, namely hostility and social support, acting jointly, may affect MMP-2 activity. Moreover, in hostile patients, there is a link between IL-1 p and MMP-9. These findings support the role of psychosocial factors in plaque destabilization and in the inflammatory process in AMI. (C) 2015 Elsevier Ltd. All rights reserved.
C1 [Fernandez Machulsky, Nahuel; Miksztowicz, Veronica; Lombardo, Micaela; Schreier, Laura; Berg, Gabriela] Univ Buenos Aires, Fac Pharm & Biochem, Dept Clin Biochem, Lipids & Atherosclerosis Lab,INFIBIOC, RA-1053 Buenos Aires, DF, Argentina.
   [Gagliardi, Juan; Garcia Escudero, Alejandro; Gigena, Gerardo; Blanco, Federico] Gen Hosp Dr Cosme Argerich, Hemodynam Unit, Div Cardiol, Buenos Aires, DF, Argentina.
   [Fabre, Bibiana] Univ Buenos Aires, Fac Pharm & Biochem, Dept Clin Biochem, Endocrinol Lab,INFIBIOC, RA-1053 Buenos Aires, DF, Argentina.
   [Gelpi, Ricardo J.] Univ Buenos Aires, Fac Med, Inst Cardiovasc Physiopathol, RA-1053 Buenos Aires, DF, Argentina.
   [Gelpi, Ricardo J.] Univ Buenos Aires, Fac Med, Dept Pathol, RA-1053 Buenos Aires, DF, Argentina.
   [Gidron, Yori] Vrije Univ Brussel, Fac Med & Pharm, Behav Med, Brussels, Belgium.
C3 University of Buenos Aires; University of Buenos Aires; Instituto
   Cardiovascular de Buenos Aires (ICBA); University of Buenos Aires;
   University of Buenos Aires; Vrije Universiteit Brussel
RP Berg, G (corresponding author), Junin 956, Caba, Argentina.
EM gaberg@ffyb.uba.ar
OI Fernandez Machulsky, Nahuel/0009-0008-2432-0806; Berg,
   Gabriela/0000-0002-5787-8960
FU University of Buenos Aires, Argentina [UBACYT: 20020010041]
FX This work was supported by a grant from the University of Buenos Aires,
   Argentina (UBACYT: 20020010041; 2012-2015).
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NR 47
TC 9
Z9 9
U1 0
U2 2
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
EI 1873-3360
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD JAN
PY 2016
VL 63
BP 102
EP 108
DI 10.1016/j.psyneuen.2015.09.015
PG 7
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA CZ9MT
UT WOS:000367422400013
PM 26431804
OA Green Published
DA 2025-06-11
ER

PT J
AU Moschonas, DP
   Piperi, C
   Korkolopoulou, P
   Levidou, G
   Kavantzas, N
   Trigka, EA
   Vlachos, I
   Arapostathi, C
   Perrea, D
   Mitropoulos, D
   Diamanti-Kandarakis, E
   Papavassiliou, AG
AF Moschonas, Dimitrios P.
   Piperi, Christina
   Korkolopoulou, Penelope
   Levidou, Georgia
   Kavantzas, Nikolaos
   Trigka, Eleni-Andriana
   Vlachos, Ioannis
   Arapostathi, Christina
   Perrea, Despina
   Mitropoulos, Dionysios
   Diamanti-Kandarakis, Evanthia
   Papavassiliou, Athanasios G.
TI Impact of diet-induced obesity in male mouse reproductive system: The
   role of advanced glycation end product-receptor for advanced glycation
   end product axis
SO EXPERIMENTAL BIOLOGY AND MEDICINE
LA English
DT Article
DE Advanced glycation end products; receptor for advanced glycation end
   product; obesity; apoptosis; testes; prostate
ID METABOLIC SYNDROME; DIABETES-MELLITUS; PROSTATE; QUALITY; RATS; MEN;
   ASSOCIATION; APOPTOSIS; TRACT; MODEL
AB Obesity represents a route to broad physiological dysfunction affecting major organs including male urogenital system. Hyperglycemia, hyperlipidemia, and oxidative stress associated with obesity augment the formation of reactive metabolic by-products, namely advanced glycation end products (AGEs), leading to increased tissue deposition and damage. The exogenous intake and the endogenous accumulation of AGEs contribute to metabolic and reproductive abnormalities in both women and men. The present study assessed the effects of a diet high in saturated fatty acids (SAFA) on the lipid and metabolic profile (AGE levels, oxidative stress) as well as pathogenic (AGE, receptor for AGEs [RAGE] expression, apoptosis) and morphometric parameters of male reproductive system in vivo. Effects of switching to a diet rich in monounsaturated fatty acids (MUFA) or equal in the proportion MUFA to SAFA were further investigated. SAFA-fed animals were characterized by increased serum lipid concentrations (p < .05) compared to controls, but AGEs and peroxide levels were not significantly different across the different experimental groups. Elevated AGE deposition was detected for the first time in germ cells with a higher staining intensity in animals on the SAFA diet, compared to MUFA or MUFA-SAFA-fed animals or the control samples (p = .018). In Leydig cells, AGE localization was higher in the entire cohort of high-fat-fed animals compared to controls (p < .05). High-fat-fed mice displayed enhanced apoptosis compared to controls (p < .005). Furthermore, prostatic tissue demonstrated reduction in epithelial folding, an effect which was significantly reversed after MUFA diet administration. Our findings provide the basis for further investigation of AGE-RAGE axis in testicular and prostatic disturbances associated with diet-induced obesity. Simple dietetic intervention has beneficial effects on metabolic dysfunction of reproductive system before overt manifestations, indicating glycation as a promising therapeutic target.
C1 [Moschonas, Dimitrios P.; Piperi, Christina; Papavassiliou, Athanasios G.] Univ Athens, Sch Med, Dept Biol Chem, GR-11527 Athens, Greece.
   [Korkolopoulou, Penelope; Levidou, Georgia; Kavantzas, Nikolaos; Trigka, Eleni-Andriana] Univ Athens, Sch Med, Dept Pathol 1, GR-11527 Athens, Greece.
   [Vlachos, Ioannis; Arapostathi, Christina; Perrea, Despina] Univ Athens, Sch Med, Lab Expt Surg & Surg Res NS Christeas, GR-11527 Athens, Greece.
   [Mitropoulos, Dionysios] Univ Athens, Sch Med, Dept Urol 1, GR-11527 Athens, Greece.
   [Diamanti-Kandarakis, Evanthia] Univ Athens, Sch Med, Dept Internal Med 3, Endocrine Unit, GR-11527 Athens, Greece.
C3 Athens Medical School; National & Kapodistrian University of Athens;
   Athens Medical School; National & Kapodistrian University of Athens;
   Athens Medical School; National & Kapodistrian University of Athens;
   Athens Medical School; National & Kapodistrian University of Athens;
   National & Kapodistrian University of Athens; Athens Medical School
RP Piperi, C (corresponding author), Univ Athens, Sch Med, Dept Biol Chem, GR-11527 Athens, Greece.
EM cpiperi@med.uoa.gr
RI Piperi, Christina/AAF-2009-2020; Mitropoulos, Dionysios/AAA-9362-2020;
   Vlachos, Ioannis/AFS-8859-2022
OI Vlachos, Ioannis/0000-0002-8849-808X; Piperi,
   Christina/0000-0002-2701-0618; Papavassiliou,
   Athanasios/0000-0001-5803-4527
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NR 35
TC 10
Z9 10
U1 0
U2 13
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1535-3702
EI 1535-3699
J9 EXP BIOL MED
JI Exp. Biol. Med.
PD AUG
PY 2014
VL 239
IS 8
BP 937
EP 947
DI 10.1177/1535370214531899
PG 11
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA AQ4MR
UT WOS:000342772600005
PM 24872429
DA 2025-06-11
ER

PT J
AU Mokra, D
   Tonhajzerova, I
   Pistekova, H
   Visnovcova, Z
   Mokry, J
   Drgova, A
   Repcakova, M
   Calkovska, A
AF Mokra, D.
   Tonhajzerova, I.
   Pistekova, H.
   Visnovcova, Z.
   Mokry, J.
   Drgova, A.
   Repcakova, M.
   Calkovska, A.
TI SHORT-TERM CARDIOVASCULAR EFFECTS OF SELECTIVE PHOSPHODIESTERASE 3
   INHIBITOR OLPRINONE VERSUS NON-SELECTIVE PHOSPHODIESTERASE INHIBITOR
   AMINOPHYLLINE IN A MECONIUM-INDUCED ACUTE LUNG INJURY
SO JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
LA English
DT Article
DE meconium aspiration; phosphodiesterase inhibitor; aminophylline;
   olprinone; cardiovascular; blood pressure; heart rate; heart rate
   variability
ID HEART-RATE-VARIABILITY; GAMMA-GLUTAMYL-TRANSFERASE; CYCLIC-NUCLEOTIDE
   PHOSPHODIESTERASES; ALANINE AMINOTRANSFERASE; PULMONARY-HYPERTENSION;
   METABOLIC SYNDROME; III INHIBITOR; SMOOTH-MUSCLE; INFLAMMATION;
   ALDOSTERONE
AB Various anti-inflammatory drugs have been used for treatment of neonatal meconium aspiration syndrome (MAS). As their adverse effects are poorly described, this study compared effects of selective phosphodiesterase (PDE) 3 inhibitor olprinone and non-selective PDE inhibitor aminophylline on cardiovascular parameters in animal model of MAS. Oxygen-ventilated rabbits were intratracheally instilled 4 mL/kg of meconium (25 mg/mL) or saline. Thirty minutes later, meconium-instilled animals were intravenously given olprinone (0.2 mg/kg) at a single dose at 0.5 h after meconium instillation, or aminophylline (2.0 mg/kg) at two doses at 0.5 and 2.5 h after meconium instillation, or were left without treatment. Cardiovascular changes were evaluated within 5 min of administration and 5 min after finishing the administration. Furthermore, respiratory and cardiovascular parameters were measured within 5 hours following treatment delivery. Oxidation markers (thiobarbituric acid-reactive substances (TBARS), and total antioxidant status) and markers of cardiovascular injury (aldosterone, gamma-glutamyltransferase (GGT), aspartate aminotransferase (AST), and alanine aminotransferase (ALT)) were determined in the plasma. Meconium instillation induced acute lung injury associated with oxidative stress, elevated aldosterone, and slightly increased GGT and AST levels. Both aminophylline and olprinone improved lung functions and reduced oxidation stress. However, the PDE inhibitors acutely increased blood pressure and heart rate, whereas heart rate variability remained higher till the end of experiment and correlated well with markers of cardiovascular injury. Considering that systemic administration of olprinone and aminophylline was accompanied by acute cardiovascular changes in the meconium-instilled animals, use of PDE inhibitors in the newborns with MAS should be carefully monitored.
C1 [Mokra, D.; Tonhajzerova, I.; Pistekova, H.; Visnovcova, Z.; Calkovska, A.] Comenius Univ, Jessenius Fac Med Martin, Dept Physiol, Martin, Slovakia.
   [Mokry, J.] Comenius Univ, Jessenius Fac Med Martin, Dept Pharmacol, Martin, Slovakia.
   [Drgova, A.; Repcakova, M.] Comenius Univ, Jessenius Fac Med Martin, Dept Med Biochem, Martin, Slovakia.
C3 Comenius University Bratislava; Comenius University Bratislava; Comenius
   University Bratislava
RP Mokra, D (corresponding author), Comenius Univ, Jessenius Fac Med, Dept Physiol, 4 Mala Hora St, SK-03601 Martin, Slovakia.
EM mokra@jfmed.uniba.sk
RI Tonhajzerova, Ingrid/X-5909-2018; Mokry, Juraj/X-6014-2018; Calkovska,
   Andrea/X-6321-2018
OI Tonhajzerova, Ingrid/0000-0002-1116-6917; Mokry,
   Juraj/0000-0001-7756-5569; Calkovska, Andrea/0000-0003-4113-3005
FU Center of Excellence in Perinatology Research (CEPV II) [26220120036];
   EU [APVV-0435-11]; VEGA [1/0057/11]
FX Authors thank M. Petraskova, M. Hutko, D. Kuliskova and Z. Remisova for
   technical assistance. Study was supported by Project Center of
   Excellence in Perinatology Research (CEPV II) No. 26220120036,
   co-financed from EU sources, by Project APVV-0435-11, and Grant VEGA No.
   1/0057/11.
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NR 44
TC 15
Z9 17
U1 0
U2 1
PU POLISH PHYSIOLOGICAL SOC
PI GRZEGORZECKA
PA JAGIELLONIAN UNIV SCHOOL MED, INST PHYSIOLOGY, 31-531 KRAKOW, 16
   GRZEGORZECKA, POLAND
SN 0867-5910
J9 J PHYSIOL PHARMACOL
JI J. Physiol. Pharmacol.
PD DEC
PY 2013
VL 64
IS 6
BP 751
EP 759
PG 9
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA 296QI
UT WOS:000330200100009
PM 24388890
DA 2025-06-11
ER

PT J
AU Keyghobadi, H
   Bozorgpoursavadjani, H
   Koohpeyma, F
   Mohammadipoor, N
   Nemati, M
   Dehghani, F
   Jamhiri, I
   Keighobadi, G
   Dastghaib, S
AF Keyghobadi, Haniyeh
   Bozorgpoursavadjani, Hadis
   Koohpeyma, Farhad
   Mohammadipoor, Nazanin
   Nemati, Marzieh
   Dehghani, Farshad
   Jamhiri, Iman
   Keighobadi, Gholamhossein
   Dastghaib, Sanaz
TI Therapeutic potential of Lactobacillus casei and Chlorella
   vulgaris in high-fat diet-induced non-alcoholic fatty liver disease
   (NAFLD)-associated kidney damages: a stereological study
SO MOLECULAR BIOLOGY REPORTS
LA English
DT Article
DE High fat diet; Oxidative stress; Non-alcoholic fatty liver disease;
   KIM-1; NGAL
ID RENAL STRUCTURE; SUPPLEMENTATION; STEATOSIS; ENZYMES
AB Background The non-alcoholic fatty liver disease (NAFLD) is prevalent in as many as 25% of adults who are afflicted with metabolic syndrome. Oxidative stress plays a significant role in the pathophysiology of hepatic and renal injury associated with NAFLD. Therefore, probiotics such as Lactobacillus casei (LBC) and the microalga Chlorella vulgaris (CV) may be beneficial in alleviating kidney injury related to NAFLD. Materials and methods This animal study utilized 30 C57BL/6 mice, which were evenly distributed into five groups: the control group, the NAFLD group, the NAFLD + CV group, the NAFLD + LBC group, and the NAFLD + CV + LBC group. A high-fat diet (HFD) was administered to induce NAFLD for six weeks. The treatments with CV and LBC were continued for an additional 35 days. Biochemical parameters, total antioxidant capacity (TAC), and the expression of kidney damage marker genes (KIM 1 and NGAL) in serum and kidney tissue were determined, respectively. A stereological analysis was conducted to observe the structural changes in kidney tissues. Results A liver histopathological examination confirmed the successful induction of NAFLD. Biochemical investigations revealed that the NAFLD group exhibited increased ALT and AST levels, significantly reduced in the therapy groups (p < 0.001). The gene expression levels of KIM-1 and NGAL were elevated in NAFLD but were significantly reduced by CV and LBC therapies (p < 0.001). Stereological examinations revealed reduced kidney size, volume, and tissue composition in the NAFLD group, with significant improvements observed in the treated groups (p < 0.001). Conclusion This study highlights the potential therapeutic efficacy of C. vulgaris and L. casei in mitigating kidney damage caused by NAFLD. These findings provide valuable insights for developing novel treatment approaches for managing NAFLD and its associated complications.
C1 [Keyghobadi, Haniyeh; Bozorgpoursavadjani, Hadis] Islamic Azad Univ, Dept Biol, Zarghan Branch, Zarghan, Iran.
   [Koohpeyma, Farhad; Nemati, Marzieh; Dastghaib, Sanaz] Shiraz Univ Med Sci, Endocrinol & Metab Res Ctr, Shiraz, Iran.
   [Koohpeyma, Farhad; Dehghani, Farshad] Shiraz Univ Med Sci, Student Res Comm, Shiraz, Iran.
   [Mohammadipoor, Nazanin] Florida State Univ, Nutr & Integrat Physiol, Tallahassee, FL USA.
   [Jamhiri, Iman] Shiraz Univ Med Sci, Mol Dermatol Res Ctr, Shiraz, Iran.
   [Keighobadi, Gholamhossein] Islamic Azad Univ, Shiraz Branch, Deparment Agr Management, Shiraz, Iran.
   [Dastghaib, Sanaz] Shiraz Univ Med Sci, Autophagy Res Ctr, Shiraz, Iran.
C3 Islamic Azad University; Shiraz University of Medical Science; Tehran
   University of Medical Sciences; Shiraz University of Medical Science;
   State University System of Florida; Florida State University; Shiraz
   University of Medical Science; Islamic Azad University; Shiraz
   University of Medical Science
RP Dastghaib, S (corresponding author), Shiraz Univ Med Sci, Endocrinol & Metab Res Ctr, Shiraz, Iran.; Dastghaib, S (corresponding author), Shiraz Univ Med Sci, Autophagy Res Ctr, Shiraz, Iran.
EM suny.respina@gmail.com
RI Dehghani, Farshad/LFV-6932-2024; Dastghaib, Sanaz/ABD-5899-2021
OI Dehghani, Farshad/0000-0002-4438-5446
FU Zarghan Branch, Islamic Azad University, Zarghan, Iran
FX The present article was extracted from the thesis written by Haniyeh
   Keyghobadi has been submitted in Department of Biology, Zarghan Branch,
   Islamic Azad University, Zarghan, Iran.
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NR 58
TC 3
Z9 3
U1 3
U2 8
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0301-4851
EI 1573-4978
J9 MOL BIOL REP
JI Mol. Biol. Rep.
PD DEC
PY 2024
VL 51
IS 1
AR 613
DI 10.1007/s11033-024-09542-1
PG 14
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA PL5E3
UT WOS:001214238700004
PM 38704764
DA 2025-06-11
ER

PT J
AU García-Prieto, CF
   Gil-Ortega, M
   Vega-Martín, E
   Ramiro-Cortijo, D
   Martín-Ramose, M
   Bordiú, E
   Sanchez-Pernaute, A
   Torres, A
   Aranguez, I
   Fernández-Alfonso, M
   Rubio, MA
   Somoza, B
AF Garcia-Prieto, Concha F.
   Gil-Ortega, Marta
   Vega-Martin, Elena
   Ramiro-Cortijo, David
   Martin-Ramose, Miriam
   Bordiu, Elena
   Sanchez-Pernaute, Andres
   Torres, Antonio
   Aranguez, I
   Fernandez-Alfonso, Maria
   Rubio, Miguel A.
   Somoza, Beatriz
TI Beneficial Effect of Bariatric Surgery on Abnormal MMP-9 and AMPK
   Activities: Potential Markers of Obesity-Related CV Risk
SO FRONTIERS IN PHYSIOLOGY
LA English
DT Article
DE obesity; bariatric surgery; matrix metalloproteinase-9; AMP-activated
   protein kinase; lactate dehydrogenase; intrinsic arterial stiffness
ID PULSE-WAVE VELOCITY; ACTIVATED PROTEIN-KINASE; ALL-CAUSE MORTALITY;
   ARTERIAL STIFFNESS; WEIGHT-LOSS; MATRIX METALLOPROTEINASES;
   CARDIOVASCULAR EVENTS; METABOLIC SYNDROME; AORTIC STIFFNESS; OXIDATIVE
   STRESS
AB Bariatric surgery (BS) results in sustained weight loss and may reverse inflammation, metabolic alterations, extracellular matrix remodeling and arterial stiffness. We hypothesize that increased stiffening in omental arteries from obese patients might be associated with an increase in MMP activity and a decrease in p-AMPK, together with systemic oxidative stress and inflammation. Moreover, BS could contribute to reversing these alterations. This study was conducted with 38 patients of Caucasian origin: 31 adult patients with morbid obesity (9 men and 22 women; mean age 46 years and BMI = 42.7 +/- 1.0 kg/m(2)) and 7 non-obese subjects (7 women; mean age 45 years and BMI = 22.7 +/- 0.6 kg/m(2)). Seventeen obese patients were studied before and 12 months after BS. The stiffness index beta, an index of intrinsic arterial stiffness, was determined in omental arteries and was significantly higher in obese patients. Levels of phosphorylated AMPK (p-AMPK(Thr-172)) and SIRT-1 were significantly lower in peripheral blood mononuclear cells (PBMCs) from obese patients than those from non-obese patients (p < 0.05) and were normalized after BS. Total and active MMP-9 activities, LDH, protein carbonyls and uric acid were higher in obese patients and reduced by BS. Moreover, there was a correlation between plasmatic LDH levels and the stiffness index beta. BS has a beneficial effect on abnormal MMP-9, LDH and AMPK activities that might be associated with the development of arterial stiffness in obese patients. Since these parameters are easily measured in blood samples, they could constitute potential biomarkers of cardiovascular risk in morbid obesity.
C1 [Garcia-Prieto, Concha F.; Gil-Ortega, Marta; Somoza, Beatriz] Univ San Pablo CEU, CEU Univ, Fac Farm, Dept Ciencias Farmaceut & Salud, Madrid, Spain.
   [Vega-Martin, Elena; Martin-Ramose, Miriam; Fernandez-Alfonso, Maria] Univ Complutense Madrid, Inst Pluridisciplinar, Fac Farm, Dept Farmacol, Madrid, Spain.
   [Ramiro-Cortijo, David] Univ Autonoma Madrid, Fac Med, Dept Fisiol, Madrid, Spain.
   [Bordiu, Elena; Rubio, Miguel A.] Univ Complutense Madrid, Inst Invest Sanitarias San Carlos, Hosp Clin San Carlos, Serv Endocrinol & Nutr,Fac Med, Madrid, Spain.
   [Sanchez-Pernaute, Andres; Torres, Antonio] Univ Complutense Madrid, Inst Invest Sanitanas San Carlos, Hosp Cin San Carlos, Fac Med,Serv Cirugia, Madrid, Spain.
   [Aranguez, I] Univ Complutense Madrid, Fac Farm, Dept Bioquim, Madrid, Spain.
C3 San Pablo CEU University; Complutense University of Madrid; Autonomous
   University of Madrid; Hospital Clinico San Carlos; Complutense
   University of Madrid; Complutense University of Madrid; Complutense
   University of Madrid
RP Gil-Ortega, M; Somoza, B (corresponding author), Univ San Pablo CEU, CEU Univ, Fac Farm, Dept Ciencias Farmaceut & Salud, Madrid, Spain.
EM mgortega@ceu.es; bsomoza.fcex@ceu.es
RI Somoza, Beatriz/M-1260-2017; Ramiro Cortijo, David/V-1217-2019; Rubio,
   Miguel Angel/GRJ-0134-2022; Fernandez-Alfonso, Maria S./F-5066-2016;
   Stefanadis, Christodoulos/ABH-2232-2020; Gil-Ortega, Marta/M-8742-2015
OI Ramiro Cortijo, David/0000-0001-7442-1586; Fernandez-Alfonso, Maria
   S./0000-0002-9110-8070; Rubio, Miguel A./0000-0002-0495-6240;
   Stefanadis, Christodoulos/0000-0001-5974-6454; Somoza Hernandez,
   Beatriz/0000-0003-1232-7791; Gil-Ortega, Marta/0000-0002-6366-8214
FU Fundacion Mutua Madrilena; Santander [GR921645]; SESCAMET; FUSP-CEU; 
   [BFU2011-25303]
FX This work has been supported by Fundacion Mutua Madrilena,
   GR921645-Santander, SESCAMET, BFU2011-25303, FUSP-CEU.
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NR 86
TC 15
Z9 17
U1 1
U2 1
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-042X
J9 FRONT PHYSIOL
JI Front. Physiol.
PD MAY 8
PY 2019
VL 10
AR 553
DI 10.3389/fphys.2019.00553
PG 12
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA HX4HZ
UT WOS:000467357000001
PM 31133882
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Nardelli, C
   Granata, I
   Iaffaldano, L
   D'Argenio, V
   Del Monaco, V
   Maruotti, GM
   Omodei, D
   Del Vecchio, L
   Martinelli, P
   Salvatore, F
   Guarracino, MR
   Sacchetti, L
   Pastore, L
AF Nardelli, Carmela
   Granata, Ilaria
   Iaffaldano, Laura
   D'Argenio, Valeria
   Del Monaco, Valentina
   Maruotti, Giuseppe Maria
   Omodei, Daniela
   Del Vecchio, Luigi
   Martinelli, Pasquale
   Salvatore, Francesco
   Guarracino, Mario Rosario
   Sacchetti, Lucia
   Pastore, Lucio
TI miR-138/miR-222 Overexpression Characterizes the miRNome of Amniotic
   Mesenchymal Stem Cells in Obesity
SO STEM CELLS AND DEVELOPMENT
LA English
DT Article
DE obesity; pregnancy; human amniotic mesenchymal stem cells; miRNome;
   RNA-sequencing
ID DIFFERENTIAL EXPRESSION ANALYSIS; HUMAN ADIPOSE-TISSUE; OXIDATIVE
   STRESS; MICRORNA; TOOL; INFLAMMATION; TARGETS; PROFILE; GALAXY
AB Clinical findings and data obtained in animal models indicate that nutrient uptake and exposure to environmental agents during pregnancy may affect fetal/newborn gestational programming, thereby resulting in obesity and/or obesity-related disorders in offspring. Human amniotic mesenchymal stem cells (hA-MSCs) differentiate into adipocytes and are thus a suitable model to investigate adipocyte functions in obesity. The aim of this study was to elucidate the miRNome of hA-MSCs and its contribution to obesity in pregnancy. To this aim we used the following: (i) high-resolution small RNA sequencing to characterize the microRNA (miRNA) profiles of hA-MSCs of 13 obese (Ob-) and 7 control (Co-) pregnant women at delivery; (ii) multiple-method integrated bioinformatics to predict the metabolic pathways potentially miRNA deregulated in Ob-hA-MSCs; and (iii) microarray mRNA expression profiling to verify obese-associated mRNA alterations. In summary, 12 miRNAs were differentially expressed between Ob-hA-MSCs and Co-hA-MSCs, with a multiple-methods bioinformatic consensus on miR-138-5p and miR-222-3p, which were overexpressed in Ob-hA-MSCs versus Co-hA-MSCs. The top 20 significant pathways predicted to be deregulated through miR-138-5p and/or miR-222-3p/target interaction included fat cell differentiation and deposits, lipid/carbohydrate homeostasis, response to stress, metabolic syndrome, heart disease, and ischemia. In conclusion, our finding of miR-138-5p/miR-222-3p overexpression in Ob-hA-MSCs, together with the transcriptomic data, suggests that these miRNAs in obese pregnancy could derange metabolic pathways previously found impaired in tissues from obese adults or in obesity-associated disorders and concur to modify gestational programming as has been demonstrated in animal models. This raises the possibility of using diet-based strategies to normalize the perinatal miRNome in obesity.
C1 [Nardelli, Carmela; Iaffaldano, Laura; D'Argenio, Valeria; Del Monaco, Valentina; Del Vecchio, Luigi; Salvatore, Francesco; Sacchetti, Lucia; Pastore, Lucio] CEINGE Biotecnol Avanzate SCa RL, Via G Salvatore 486, I-80145 Naples, Italy.
   [Nardelli, Carmela; Iaffaldano, Laura; D'Argenio, Valeria; Del Vecchio, Luigi; Salvatore, Francesco; Pastore, Lucio] Univ Napoli Federico II, Dipartimento Med Mol & Biotecnol Med, Naples, Italy.
   [Granata, Ilaria; Guarracino, Mario Rosario] CNR, Inst High Performance Comp & Networking ICAR, LabGTP Lab Genom Transcript & Prote, I-80131 Naples, Italy.
   [Maruotti, Giuseppe Maria; Martinelli, Pasquale] Univ Napoli Federico II, Dipartimento Neurosci & Sci Riprodutt Odontostoma, Naples, Italy.
   [Omodei, Daniela] CNR, Inst Genet & Biophys Adriano Buzzati Traverso, Naples, Italy.
C3 CEINGE Biotecnologie Avanzate; University of Naples Federico II;
   Consiglio Nazionale delle Ricerche (CNR); Istituto di Calcolo e Reti ad
   Alte Prestazioni (ICAR-CNR); University of Naples Federico II; Consiglio
   Nazionale delle Ricerche (CNR); Istituto di Genetica e Biofisica
   "Adriano Buzzati-Traverso" (IGB-CNR)
RP Sacchetti, L; Pastore, L (corresponding author), CEINGE Biotecnol Avanzate SCa RL, Via G Salvatore 486, I-80145 Naples, Italy.; Guarracino, MR (corresponding author), CNR, Inst High Performance Comp & Networking ICAR, LabGTP Lab Genom Transcript & Prote, I-80131 Naples, Italy.
EM mario.guarracino@cnr.it; lucia.sacchetti@unina.it;
   pastore@ceinge.unina.it
RI Nardelli, Carmela/AAE-2089-2020; Iaffaldano, Laura/AAL-6083-2021;
   Salvatore, Francesco/A-1966-2011; D'Argenio, Valeria/K-9345-2016;
   Pastore, Lucio/AAF-3487-2019; Guarracino, Mario Rosario/L-3815-2013;
   Maruotti, Giuseppe/K-8763-2018; Granata, Ilaria/Q-2830-2018
OI Salvatore, Francesco/0000-0002-2346-3564; Omodei,
   Daniela/0000-0001-8710-2971; Iaffaldano, Laura/0000-0001-7673-5503;
   D'Argenio, Valeria/0000-0001-9273-3698; Pastore,
   Lucio/0000-0001-6894-9317; Guarracino, Mario
   Rosario/0000-0003-2870-8134; Maruotti, Giuseppe/0000-0002-9666-6338;
   Granata, Ilaria/0000-0002-3450-4667
FU Regione Campania, Italy; Italian Ministry of University and Research
   [PON02_00677 (BIOGENE) Pot. lab. 8 A/B-2012]
FX The authors thank Jean Ann Gilder (Scientific Communication srl, Naples)
   for editing the text and Vittorio Lucignano, CEINGE-Biotecnologie
   Avanzate for technical assistance related to graphics. This work was
   supported by grant POR CAMPANIA FSER 2007-2013 Project DIA-INTECH and
   grant CAMPUS-Bioframe, from Regione Campania, Italy; grant PON02_00677
   (BIOGENE) Pot. lab. 8 A/B-2012 from the Italian Ministry of University
   and Research. Centro di Ricerca per lo studio di malattie genetiche
   dell'uomo e loro modelli cellulari e animali-Progetto: Terapia genica
   delle malattie metaboliche.
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NR 45
TC 19
Z9 21
U1 0
U2 8
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1547-3287
EI 1557-8534
J9 STEM CELLS DEV
JI Stem Cells Dev.
PD JAN 1
PY 2017
VL 26
IS 1
BP 4
EP 14
DI 10.1089/scd.2016.0127
PG 11
WC Cell & Tissue Engineering; Hematology; Medicine, Research &
   Experimental; Transplantation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Hematology; Research & Experimental Medicine;
   Transplantation
GA EH4LY
UT WOS:000391743900002
PM 27762728
DA 2025-06-11
ER

PT J
AU Tholstrup, T
   Raff, M
   Straarup, EM
   Lund, P
   Basu, S
   Bruun, JM
AF Tholstrup, Tine
   Raff, Marianne
   Straarup, Ellen M.
   Lund, Pia
   Basu, Samar
   Bruun, Jens M.
TI An oil mixture with trans-10, cis-12 conjugated linoleic
   acid increases markers of inflammation and in vivo lipid peroxidation
   compared with cis-9, trans-11 conjugated linoleic acid in
   postmenopausal women
SO JOURNAL OF NUTRITION
LA English
DT Article
ID C-REACTIVE PROTEIN; PLASMINOGEN-ACTIVATOR INHIBITOR;
   CORONARY-ARTERY-DISEASE; ISCHEMIC-HEART-DISEASE; METABOLIC SYNDROME;
   OXIDATIVE STRESS; CARDIOVASCULAR-DISEASE; INSULIN-RESISTANCE; 3T3-L1
   ADIPOCYTES; BODY-COMPOSITION
AB A mixture of trans-10, cis-12 (t10,c12) and cis-9, trans-11 (c9, t11) conjugated linoleic acid (CLA mixture) reduced atherosclerosis in animals, thus the effect of these isomers on endothelial dysfunctions leading to inflammation and atherosclerosis is of interest. We gave 75 healthy postmenopausal women a daily supplement of 5.5 g of oil rich in either CLA mixture, an oil rich in the naturally occurring c9,t11 CLA (CLA rnilk), respectively, or olive oil for 16 wk in a double-blind, randomized, parallel intervention study. We sampled blood and urine before and after the intervention. The ratios of total cholesterol:HDL cholesterol and concentrations of C-reactive protein, fibrinogen, and plasminogen activator inhibitor-1 were significantly higher in women supplemented with the CLA mixture than in those supplemented with CLA milk. Plasma triacylglycerol was significantly higher and HDL cholesterol was lower in women supplemented with the CLA mixture than with olive oil. Both CLA supplements increased lipid peroxidation, a marker of in vivo oxidative stress measured as urinary free 8-iso-prbstaglandin F-2 alpha. However, the CLA mixture increased lipid peroxidation more than the CLA milk did. The plasma cytokines interleukin-6 and tumor necrosis factor-a were not affected by the treatments, nor were any of the other variables measured. In conclusion, oil containing trans-10,cis-12 CLA has several adverse effects on classical and novel markers of coronary vascular disease, whereas the c9, t11 CLA isomer is more neutral, except for a small but significant increase in lipid peroxidation compared with olive oil.
C1 [Tholstrup, Tine; Raff, Marianne] Univ Copenhagen, Fac Life Sci, Dept Human Nutr, DK-1958 Frederiksberg, Denmark.
   [Straarup, Ellen M.; Lund, Pia] Tech Univ Denmark, BioCentrum, Biochem & Nutr Grp, DK-2800 Lyngby, Denmark.
   [Basu, Samar] Uppsala Univ, Fac Med, Dept Publ Hlth Caring Sci, Uppsala 75105, Sweden.
   [Bruun, Jens M.] Aarhus Univ Hosp, Dept Endocrinol & Metab C, DK-8000 Aarhus C, Denmark.
C3 University of Copenhagen; Technical University of Denmark; Uppsala
   University; Aarhus University
RP Tholstrup, T (corresponding author), Univ Copenhagen, Fac Life Sci, Dept Human Nutr, DK-1958 Frederiksberg, Denmark.
EM tth@life.ku.dk
OI Bruun, Jens/0000-0001-9937-5467
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NR 61
TC 88
Z9 93
U1 0
U2 15
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0022-3166
EI 1541-6100
J9 J NUTR
JI J. Nutr.
PD AUG
PY 2008
VL 138
IS 8
BP 1445
EP 1451
DI 10.1093/jn/138.8.1445
PG 7
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 332UG
UT WOS:000258108000008
PM 18641189
OA Bronze
DA 2025-06-11
ER

PT J
AU Takahashi, T
   Seol, J
   Kokubo, T
   Goto, K
   Takanari, J
AF Takahashi, Tsukasa
   Seol, Jaehoon
   Kokubo, Toshio
   Goto, Kazunori
   Takanari, Jun
TI An extract from asparagus improves sleep quality and reduces sleepiness
   and fatigue on awakening: A pilot randomized controlled trial
SO FUNCTIONAL FOODS IN HEALTH AND DISEASE
LA English
DT Article
DE Sleep debts; electroencephalogram; ETAS (R) 50; InSomnograf K2 (R)
ID NERVOUS-SYSTEM; STRESS
AB Background: Good sleep is essential for a healthy, active life that supports disease prevention. Sleep debts caused by sleep deprivation, irregular sleep, and insomnia increase the risk of metabolic syndrome, mood disorders, dementia, and cancer. Today's lifestyles in developed countries are prone to sleep debts, which has led to social interventions that aim to reduce sleep-related health problems. ETAS (R) 50 is a standardized extract of Asparagus officinalis stem, and has been reported to improve sleep quality, maintain sleep rhythms, and relieve mental stress. Methods: This pilot randomized, double-blind, placebo-controlled, crossover study was conducted in healthy adult males with sleep problems to evaluate the effects of ETAS (R) 50 on sleep quality. Participants took ETAS (R) 50 (300 mg/day) or placebo, and underwent an electroencephalogram, measured during sleep with a device known as the InSomnograf K2 (R). They were given a subjective assessment of sleep through a questionnaire known as the Oguri-Shirakawa-Azumi sleep inventory, specifically the Middle-Aged and Aged version (OSA-MA). Trial registration: the University Hospital Medical Information Network Clinical Trial Registry UMIN000052913. Results: ETAS (R) 50 showed a tendency to increase the ratio and total duration of Stage N3, known as the deepest stage in non-REM sleep (NREM). In addition, the subjective evaluation of sleep showed significant improvements in scores corresponding to tiredness upon rising, initiation and maintenance of sleep, refreshment after waking, and total scores. The total duration and ratio of Stage N3 are important indicators for assessing sleep quality. The favorable results suggested that dietary intake of ETAS (R) 50 may improve sleep quality, enhancing subjective sleep assessment the next morning. Conclusion: Supplementation of ETAS (R) 50 may offer a practical approach to improving sleep quality.
C1 [Takahashi, Tsukasa; Goto, Kazunori; Takanari, Jun] Amino Co Ltd, 363-32 Shin Ei,Kiyota Ku, Sapporo 0040839, Japan.
   [Seol, Jaehoon] Univ Tsukuba, Fac Hlth & Sport Sci, Tsukuba 3058574, Japan.
   [Seol, Jaehoon; Kokubo, Toshio] Univ Tsukuba, Int Inst Integrat Sleep Med, Tsukuba 3058575, Japan.
   [Seol, Jaehoon] Japan Soc Promot Sci, Tokyo 1020082, Japan.
   [Kokubo, Toshio] SUIMIN Inc, Shibuya 1510061, Japan.
C3 Amino-Chem; University of Tsukuba; University of Tsukuba; Japan Society
   for the Promotion of Science
RP Goto, K (corresponding author), Amino Co Ltd, 363-32 Shin Ei,Kiyota Ku, Sapporo 0040839, Japan.
RI Seol, Jaehoon/AAC-1408-2019
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NR 34
TC 0
Z9 0
U1 1
U2 1
PU FUNCTIONAL FOOD CENTER INC
PI DALLAS
PA 5050 QUORUM DR, STE 700,  NO 338, DALLAS, TX 75254 USA
SN 2160-3855
J9 FUNCT FOODS HEALTH D
JI Funct. Foods Health Dis.
PD APR
PY 2025
VL 15
IS 4
BP 191
EP 204
DI 10.31989/ffhd.v15i4.1554
PG 14
WC Food Science & Technology
WE Emerging Sources Citation Index (ESCI)
SC Food Science & Technology
GA 1HY8Y
UT WOS:001465464000001
DA 2025-06-11
ER

PT J
AU Baudin, J
   Hernandez-Baixauli, J
   Romero-Giménez, J
   Yang, H
   Mulero, F
   Puiggròs, F
   Mardinoglu, A
   Arola, L
   Caimari, A
AF Baudin, Julio
   Hernandez-Baixauli, Julia
   Romero-Gimenez, Jordi
   Yang, Hong
   Mulero, Francisca
   Puiggros, Francesc
   Mardinoglu, Adil
   Arola, Lluis
   Caimari, Antoni
TI A cocktail of histidine, carnosine, cysteine and serine reduces
   adiposity and improves metabolic health and adipose tissue
   immunometabolic function in ovariectomized rats
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Article
DE Histidine; Serine; Carnosine; Cysteine; Menopause; Obesity;
   Immunometabolic health; Nutraceuticals; Complementary and alternative
   therapies
ID ELEVATED PLUS-MAZE; NF-KAPPA-B; INSULIN-RESISTANCE; OXIDATIVE STRESS;
   BODY-COMPOSITION; CELL FUNCTION; FOOD-INTAKE; EXPRESSION; INFLAMMATION;
   SUPPLEMENTATION
AB Many women have sought alternative therapies to address menopause. Recently, a multi-ingredient supplement (MIS) containing L-histidine, L-carnosine, L-serine, and L-cysteine has been shown to be effective at ameliorating hepatic steatosis (HS) in ovariectomized (OVX) rats, a postmenopausal oestrogen deficiency model. Considering that HS frequently accompanies obesity, which often occurs during menopause, we aimed to investigate the effects of this MIS for 8 weeks in OVX rats. Twenty OVX rats were orally supplemented with either MIS (OVX-MIS) or vehicle (OVX). Ten OVX rats received vehicle orally along with subcutaneous injections of 17 beta-oestradiol (OVX-E2), whereas 10 rats underwent a sham operation and received oral and injected vehicles (control group). MIS consumption partly counteracted the fat mass accretion observed in OVX animals, leading to decreased total fat mass, adiposity index and retroperitoneal white adipose tissue (RWAT) adipocyte hypertrophy. OVX-MIS rats also displayed increased lean mass and lean/fat ratio, suggesting a healthier body composition, similar to the results reported for OVX-E2 animals. MIS consumption decreased the circulating levels of the proinflammatory marker CRP, the total cholesterol-to-HDL-cholesterol ratio and the leptin-to-adiponectin ratio, a biomarker of diabetes risk and metabolic syndrome. RWAT transcriptomics indicated that MIS favourably regulated genes involved in adipocyte structure and morphology, cell fate determination and differentiation, glucose/insulin homeostasis, inflammation, response to stress and oxidative phosphorylation, which may be mechanisms underlying the beneficial effects described for OVX-MIS rats. Our results pave the way for using this MIS formulation to improve the body composition and immunometabolic health of menopausal women.
C1 [Baudin, Julio; Hernandez-Baixauli, Julia; Romero-Gimenez, Jordi] Eurecat, Ctr Tecnol Catalunya, Technol Unit Nutr & Hlth, Reus 43204, Spain.
   [Baudin, Julio; Arola, Lluis] Univ Rovira i Virgili, Dept Biochem & Biotechnol, Nutrigenom Res Grp, Tarragona 43007, Spain.
   [Yang, Hong; Mardinoglu, Adil] KTH Royal Inst Technol, Sci Life Lab, SE-17165 Stockholm, Sweden.
   [Mulero, Francisca] Spanish Natl Canc Res Ctr CNIO, Mol Imaging Unit, Madrid, Spain.
   [Puiggros, Francesc; Caimari, Antoni] Eurecat, Ctr Tecnol Catalunya, Biotechnol Area, Reus 43204, Spain.
   [Mardinoglu, Adil] Kings Coll London, Fac Dent Oral & Craniofacial Sci, Ctr Host Microbiome Interact, London, England.
   [Hernandez-Baixauli, Julia] Univ Autonoma Barcelona, Vall dHebron Inst Recerca, Lab Metab & Obes, Barcelona, Spain.
C3 Universitat Rovira i Virgili; Royal Institute of Technology; Centro
   Nacional de Investigaciones Oncologicas (CNIO); University of London;
   King's College London; Autonomous University of Barcelona; Hospital
   Universitari Vall d'Hebron; Vall d'Hebron Institut de Recerca (VHIR)
RP Arola, L (corresponding author), Univ Rovira i Virgili, Dept Biochem & Biotechnol, Nutrigenom Res Grp, Tarragona 43007, Spain.; Caimari, A (corresponding author), Eurecat, Ctr Tecnol Catalunya, Biotechnol Area, Reus 43204, Spain.
EM lluis.arola@urv.cat; antoni.caimari@eurecat.org
RI Mardinoglu, Adil/LTC-9598-2024; Puiggros, Francesc/AAA-6359-2019; Arola,
   Lluís/C-6074-2011; Hernandez-Baixauli, Julia/MGU-3950-2025; Mulero,
   Francisca/R-2387-2019
OI Mardinoglu, Adil/0000-0002-4254-6090; Quesada Vazquez,
   Sergio/0000-0001-6588-1193; Hernandez Baixauli,
   Julia/0000-0002-9166-4173
FU Agency for Business Competitiveness of the Government of Catalonia
   [ACCIO<acute accent>/TECCT11-1-<acute accent>/TECCT11-1-0012]; Comunidad
   de Madrid [S2022/BMD-7403 RENIM-CM]
FX Funding sources This research was financially supported by the Agency
   for Business Competitiveness of the Government of Catalonia (ACCIO<acute
   accent>/TECCT11-1-<acute accent>/TECCT11-1-0012) and by Comunidad de
   Madrid (S2022/BMD-7403 RENIM-CM) .
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NR 133
TC 1
Z9 1
U1 5
U2 6
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD OCT
PY 2024
VL 179
AR 117326
DI 10.1016/j.biopha.2024.117326
EA AUG 2024
PG 18
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA F7V1A
UT WOS:001311839600001
PM 39208671
OA gold
DA 2025-06-11
ER

PT J
AU Wal, P
   Rathore, S
   Aziz, N
   Singh, YK
   Gupta, A
AF Wal, Pranay
   Rathore, Shruti
   Aziz, Namra
   Singh, Yash Kumar
   Gupta, Arpit
TI Aortic stenosis: a review on acquired pathogenesis and ominous
   combination with diabetes mellitus
SO EGYPTIAN HEART JOURNAL
LA English
DT Review
DE Aortic stenosis; Diabetic mellitus; Valve calcification; Calcified
   aortic valve stenosis; Degenerative aortic stenosis
ID CARDIOVASCULAR MAGNETIC-RESONANCE; CONVERTING ENZYME-INHIBITORS;
   KAPPA-B; VALVE CALCIFICATION; INTERSTITIAL-CELLS; METABOLIC SYNDROME;
   RISK-FACTORS; DISEASE; PROGRESSION; OUTCOMES
AB Background Aortic stenosis (AS) is a progressive disease, with no pharmacological treatment. The prevalence of diabetes mellitus (DM) among AS patients is higher than in the general population. DM significantly increases the risk of AS development and progression from mild to severe. The interplay between AS and DM's mechanism is not entirely known yet.
   Main Body The increased accumulation of advanced glycation end products (AGEs) was linked to increased valvular oxidative stress, inflammation, expression of coagulation factors, and signs of calcification, according to an analysis of aortic stenotic valves. It is interesting to note that in diabetic AS patients, valvular inflammation did not correlate with serum glucose levels but rather only with long-term glycemic management markers like glycated haemoglobin and fructosamine. Transcatheter aortic valve replacement, which has been shown to be safer than surgical aortic valve replacement, is advantageous for AS patients who also have concurrent diabetes. Additionally, novel anti-diabetic medications have been proposed to lower the risk of AS development in DM patients, including sodium-glucose cotransporter-2 inhibitors and glucagon-like peptide-1 receptor agonist that target reduction of AGEs-mediated oxidative stress.
   Conclusions There are little data on the effects of hyperglycemia on valvular calcification, but understanding the interactions between them is essential to develop a successful treatment strategy to stop or at least slow the progression of AS in DM patients. There is a link among AS and DM and that DM negatively impacts the quality of life and longevity of AS patients. The sole successful treatment, despite ongoing efforts to find new therapeutic modalities, involves aortic valve replacement. More research is required to find methods that can slow the advancement of these conditions, enhancing the prognosis and course of people with AS and DM.
C1 [Wal, Pranay; Aziz, Namra; Singh, Yash Kumar; Gupta, Arpit] Pranveer Singh Inst Technol, Pharm, Kanpur 209305, Uttar Pradesh, India.
   [Rathore, Shruti] LCIT Sch Pharm, Bilaspur 495220, Chhattisgarh, India.
RP Wal, P (corresponding author), Pranveer Singh Inst Technol, Pharm, Kanpur 209305, Uttar Pradesh, India.
EM drpranaywal@gmail.com
RI Rathore, Dr Shruti/AFF-7202-2022; Wal, Pranay/ABA-7278-2021
OI Aziz, Namra/0000-0003-1774-1043; Wal, Pranay/0000-0002-6342-6290; Singh,
   Yash kumar/0000-0001-7022-8279
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NR 107
TC 4
Z9 4
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1110-2608
EI 2090-911X
J9 EGYPT HEART J
JI Egypt. Heart J.
PD APR 7
PY 2023
VL 75
IS 1
AR 26
DI 10.1186/s43044-023-00345-6
PG 17
WC Cardiac & Cardiovascular Systems
WE Emerging Sources Citation Index (ESCI)
SC Cardiovascular System & Cardiology
GA C9QT5
UT WOS:000965187900001
PM 37027109
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Savova, MS
   Todorova, MN
   Binev, BK
   Georgiev, MI
   Mihaylova, LV
AF Savova, Martina S.
   Todorova, Monika N.
   Binev, Biser K.
   Georgiev, Milen I.
   Mihaylova, Liliya V.
TI Curcumin enhances the anti-obesogenic activity of orlistat through
   SKN-1/NRF2-dependent regulation of nutrient metabolism in
   Caenorhabditis elegans
SO INTERNATIONAL JOURNAL OF OBESITY
LA English
DT Article
ID C. ELEGANS; ACCUMULATION; RESTRICTION; SKN-1/NRF
AB BackgroundMetabolic dysregulation, a defining feature of obesity, disrupts essential signalling pathways involved in nutrient sensing and mitochondria homeostasis. The nuclear factor erythroid 2-related factor 2 (NRF-2) serves as a pivotal regulator of the cellular stress response, and recent studies have implicated it in the pathogenesis of obesity, diabetes, and metabolic syndrome. Curcumin, a polyphenolic compound derived from turmeric, has been identified as a potent activator of NRF-2. Evidence suggests curcumin impacts obesity and metabolic disorders by modulating gut microbiota composition, increasing energy expenditure, and regulating lipid metabolism. Orlistat, an anti-obesity drug, inhibits fat absorption in the gastrointestinal tract, but its side effects limits its broader use.ObjectivesThe present study aims to investigate the potential synergetic effect of a hybrid combination between orlistat and curcumin. Additionally, we provide a detailed understanding of the molecular mechanisms through which this combination mitigates glucose-induced lipid accumulation in Caenorhabditis elegans, with a focus on the role of the skinhead 1 (SKN-1) transcription factor, an orthologue of NRF2.MethodsWe assessed the lipid accumulation and the changes in skn-1 transcriptional activity in C. elegans using confocal GFP-based detection, alongside mRNA expression analysis of genes from lipid metabolism and oxidative stress response in wild-type, QV225 and LD1 strains. Furthermore, we evaluated locomotion, chemotaxis and mitochondrial dynamics to enhance our understanding of the proposed molecular-based model.ResultsOur findings reveal that the orlistat/curcumin combination exerts an anti-obesogenic effect through SKN-1/NRF2-dependent regulation of conserved genes involved in carbohydrate and lipid metabolism in C. elegans. Moreover, the combination stimulates mitochondrial potential, further contributing to the observed synergistic effects.ConclusionThe hybrid combination of orlistat and curcumin demonstrates significant anti-obesity activity by regulating nutrient-sensing pathways through SKN-1/NRF-2 modulation. This approach may allow for the reduction of orlistat dosage, thereby minimizing its adverse effects while maintaining its therapeutic efficacy.
C1 [Savova, Martina S.; Todorova, Monika N.; Binev, Biser K.; Georgiev, Milen I.; Mihaylova, Liliya V.] Bulgarian Acad Sci, Inst Microbiol, Dept Biotechnol, Lab Metabol, 139 Ruski Blvd, Plovdiv 4000, Bulgaria.
   [Savova, Martina S.; Todorova, Monika N.; Binev, Biser K.; Georgiev, Milen I.; Mihaylova, Liliya V.] Ctr Plant Syst Biol & Biotechnol, Dept Plant Cell Biotechnol, Plovdiv 4000, Bulgaria.
C3 Bulgarian Academy of Sciences
RP Mihaylova, LV (corresponding author), Bulgarian Acad Sci, Inst Microbiol, Dept Biotechnol, Lab Metabol, 139 Ruski Blvd, Plovdiv 4000, Bulgaria.; Mihaylova, LV (corresponding author), Ctr Plant Syst Biol & Biotechnol, Dept Plant Cell Biotechnol, Plovdiv 4000, Bulgaria.
EM l.mihaylova@microbio.bas.bg
RI Georgiev, Milen/P-6948-2015; Savova, Martina/MGB-2678-2025; Mihaylova,
   Liliya/I-6017-2016
OI Todorova, Monika/0009-0000-2892-7420; Georgiev, Milen
   I./0000-0001-5248-6135; Mihaylova, Liliya/0000-0002-1690-1490
FU Bulgarian National Science Fund [BG-175467353-2023-03,
   Kcy;Pcy;-06-Kcy;Ocy;Scy;Tcy;/4]; European Union [739582, 664620];
   European Regional Development Fund through the Bulgarian "Science and
   Education for Smart Growth" Operational Programme
   [BG05M2OP001-1.003-0001-C01]; Programme Research Innovation and
   Digitalisation for Smart Transformation; COST Action [CA20121]; COST
   (European Cooperation in Science and Technology)
FX This research received funding from the Bulgarian National Science Fund
   under BG-175467353-2023-03 programme for project Natural NRF2 activators
   modulating obesity mechanisms: molecular pharmacology-based in vivo
   study (contract number & Kcy;& Pcy;-06-& Kcy;& Ocy;& Scy;& Tcy;/4), the
   European Union's Horizon 2020 research and innovation programme, project
   PlantaSYST (SGA No 739582 under FPA No. 664620) and by the European
   Regional Development Fund through the Bulgarian "Science and Education
   for Smart Growth" Operational Programme (project
   BG05M2OP001-1.003-0001-C01) and Programme Research Innovation and
   Digitalisation for Smart Transformation. This article is based upon work
   from COST Action CA20121 BenBedPhar, supported by COST (European
   Cooperation in Science and Technology).
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NR 59
TC 0
Z9 0
U1 10
U2 10
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0307-0565
EI 1476-5497
J9 INT J OBESITY
JI Int. J. Obes.
PD MAR
PY 2025
VL 49
IS 3
BP 516
EP 526
DI 10.1038/s41366-025-01724-6
EA JAN 2025
PG 11
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 0ZC3E
UT WOS:001405004700001
PM 39856245
DA 2025-06-11
ER

PT J
AU Geetha, V
   Chathur, KN
   Ramkumar, S
   Halami, PM
   Kumar, GS
AF Geetha, V.
   Chathur, K. N.
   Ramkumar, Smita
   Halami, Prakash M.
   Kumar, G. Suresh
TI In vitro fermentation of glycosaminoglycans from mackerel fish
   waste and its role in modulating the antioxidant status and gut
   microbiota of high fat diet-fed C57BL/6 mice
SO FOOD & FUNCTION
LA English
DT Article
ID SEA-CUCUMBER; DNA-DAMAGE; INTESTINAL MICROBIOTA; LIPID-PEROXIDATION;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; OXIDATIVE STRESS;
   ADIPOSE-TISSUE; POLYSACCHARIDES; ACID
AB Bioactive polysaccharides such as glycosaminoglycans (GAGs) exhibit potential health benefits for several health complications including obesity. The gut microbiota plays a key role in regulating host metabolism, nutrition and immunity. The present work assessed the potential of extracted GAGs (e-GAGs) in maintaining the gut microbiota and ameliorating the effects of high fat diet in in vitro and in vivo models. The in vitro fermentability of e-GAGs extracted from mackerel fish waste was analyzed with Lactobacillus plantarum (LP) and Bifidobacterium bifidum (BB); e-GAGs at 0.5 and 1% proved their prebiotic nature up to 48 h. The pH value decreased from 6.23 to 3.32, the cell density increased from 1.70 to 2.32, the viable cell count increased from 8 to 12 log CFU mL(-1), and short chain fatty acid (SCFA) production was & AP;33, 31 and 36% for LP and & AP;37, 29 and 34% for BB in terms of acetic acid, propionic acid and butyric acid, respectively. In vivo studies on high fat diet (HFD)-fed C57BL/6 mice with e-GAGs (380 and 760 mg kg(-1) diet) showed ameliorated gut microbiome and tissue/plasma antioxidant enzyme activities, and also the e-GAG-fed group showed significantly (P < 0.05) decreased lipid peroxidation. Cecal microbial analysis showed the health-promoting effects of e-GAGs in reducing (P < 0.05) the obesity ratio of Firmicutes to Bacteroidetes (F/B) within the range (5.32 and 5.26) compared with HFD (6.23). Hence, e-GAGs can be a potential molecule for the treatment of obesity by restoring the redox status under oxidative stress and ameliorating the gut microbes that produce SCFAs which are known to have health beneficial effects.
C1 [Geetha, V.; Ramkumar, Smita; Kumar, G. Suresh] Cent Food Technol Res Inst, CSIR, Dept Biochem, Mysuru 570020, India.
   [Chathur, K. N.] Cent Food Technol Res Inst, CSIR, Dept Food Protectants & Infestat Control, Mysuru 570020, India.
   [Halami, Prakash M.] Cent Food Technol Res Inst, CSIR, Dept Microbiol & Fermentat Technol, Mysuru 570020, India.
   [Ramkumar, Smita; Halami, Prakash M.; Kumar, G. Suresh] Acad Sci & Innovat Res AcSIR, Ghaziabad, India.
   [Geetha, V.; Kumar, G. Suresh] Mangalore Univ, Dept Biosci, Mangalore 574199, Karnataka, India.
C3 Council of Scientific & Industrial Research (CSIR) - India; CSIR -
   Central Food Technological Research Institute (CFTRI); Council of
   Scientific & Industrial Research (CSIR) - India; CSIR - Central Food
   Technological Research Institute (CFTRI); Council of Scientific &
   Industrial Research (CSIR) - India; CSIR - Central Food Technological
   Research Institute (CFTRI); Academy of Scientific & Innovative Research
   (AcSIR); Mangalore University
RP Kumar, GS (corresponding author), Cent Food Technol Res Inst, CSIR, Dept Biochem, Mysuru 570020, India.
EM sureshg@cftri.res.in
FU Indian Council of Medical Research, New Delhi; ICMR-SRF Fellowship
   [3/1/2/94/2018-Nut]; Department of Biosciences, Mangalore University,
   Mangalagangothri, Mangalore;  [MLP-245];  [GAP-561]
FX The authors would like to thank the Director, CSIR-Central Food
   Technological Research Institute, Mysuru, India, for constant support
   and encouragement, and also thank Vijnana Bhavana - a central
   instrumentation facility as Institution of Excellence (IOE) of
   University of Mysuru, Mysuru for the Scanning Electron Microscopy
   facility. The author Geetha V would like to thank the Indian Council of
   Medical Research, New Delhi, for the ICMR-SRF Fellowship (Grant #
   3/1/2/94/2018-Nut) and Department of Biosciences, Mangalore University,
   Mangalagangothri, Mangalore. Financial assistance for this research work
   was provided by the MLP-245 and GAP-561 projects.
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NR 96
TC 5
Z9 5
U1 7
U2 28
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PD JUL 31
PY 2023
VL 14
IS 15
BP 7130
EP 7145
DI 10.1039/d2fo03603g
EA JUL 2023
PG 16
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA N2XS4
UT WOS:001030542800001
PM 37461843
DA 2025-06-11
ER

PT J
AU El-Beshbishy, HA
   Maria, RA
   Bardi, FA
AF El-Beshbishy, Hesham A.
   Maria, Reham A.
   Bardi, Fouad A.
TI Biochemical and C-Reactive Protein Alterations in Myocardial Infarction
   Periodontitis Patients
SO AMERICAN JOURNAL OF THE MEDICAL SCIENCES
LA English
DT Article
DE C-reactive protein; Periodontitis; Oxidative stress; Acute myocardial
   infarction
ID SYSTEMIC INFLAMMATION; METABOLIC SYNDROME; OXIDATIVE STRESS; DISEASE;
   SERUM; GINGIVAL; RESISTIN; RISK; PROGRESSION; EXPRESSION
AB Periodontitis (PD) is a risk factor for acute myocardial infarction (AMI). C-reactive protein (CRP) is elevated in PD. The aim of this study was to investigate biochemical alterations among AMI with PD. Thirty non-AMI (25 non-PD and only 5 PD) and 30 AMI (13 PD and 17 non-PD) patients were participated. Serum CRP, tumor necrosis factor alpha (TNF-alpha), total cholesterol, low-density lipoprotein cholesterol, protein carbonyl (PC) contents, soluble vascular cell adhesion molecule-1 (sVCAM-1), adiponectin, creatine kinase, resistin, catalase and superoxide dismutase (SOD) levels were measured. AMI-PD elicited significant differences in percentage hypertension, diabetes, serum creatine kinase, cholesterol and low-density lipoprotein cholesterol. CRP among AMI-PD and non-AMI-PD was increased by 73.4% and 31.3%, respectively. The level of PC contents was increased significantly among AMI-PD and non-AMI-PD by 47.62% and 33.3%, respectively. Catalase and SOD levels were significantly decreased in AMI-PD by 33.7% and 34.1%, respectively; however, their levels among non-AMI-PD were significantly increased by 35.7% and 28%, respectively. TNF-alpha, sVCAM-1 and resistin levels among AMI-PD were increased by 134.3%, 68.8% and 25.5%, respectively; however, TNF-alpha and sVCAM-1 levels among non-AMI-PD were increased significantly by 21.4% and 29.4%, respectively. Adiponectin level produced insignificant changes. PD prevalence among AMI associated with elevated serum CRP, PC contents, sVCAM-1, TNF-alpha and resistin levels concurrent with declines in SOD and catalase enzymes. In conclusion, among nondiabetic, nonsmoking patients suffering from AMI, PD is highly prevalent and associated with elevated serum CRP, PC contents, sVCAM-1, TNF-alpha and resistin levels, associated with significant declines in antioxidant enzymes with insignificant change in serum adiponectin level.
C1 [El-Beshbishy, Hesham A.] Taibah Univ, Fac Appl Med Sci, Med Labs Technol Dept, Al Madinah Al Munawarah, Saudi Arabia.
   [Maria, Reham A.] Tanta Univ, Fac Med, Dept Med Biochem, Tanta, Egypt.
   [Bardi, Fouad A.] Minist Hlth, Al Madinah Al Munawarah, Saudi Arabia.
   [El-Beshbishy, Hesham A.] Al Azhar Univ, Fac Pharm, Dept Biochem, Cairo, Egypt.
C3 Taibah University; Egyptian Knowledge Bank (EKB); Tanta University;
   Egyptian Knowledge Bank (EKB); Al Azhar University
RP El-Beshbishy, HA (corresponding author), Taibah Univ, Fac Appl Med Sci, Med Labs Technol Dept, POB 30001, Al Madinah Al Munawarah, Saudi Arabia.
EM hesham_elbeshbishy@hotmail.com
RI Maria, Reham/JLL-4322-2023; El-Beshbishy, Prof. Hesham/C-8965-2019
OI El-Beshbishy, Prof. Hesham/0000-0002-4357-0981
FU Deanship of Scientific Research, Taibah University, Al-madinah
   Al-munawarah, Saudi Arabia [586/432]
FX This study was supported by Grant 586/432 from the Deanship of
   Scientific Research, Taibah University, Al-madinah Al-munawarah, Saudi
   Arabia.
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NR 33
TC 5
Z9 6
U1 0
U2 4
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0002-9629
EI 1538-2990
J9 AM J MED SCI
JI Am. J. Med. Sci.
PD SEP
PY 2014
VL 348
IS 3
BP 181
EP 185
DI 10.1097/MAJ.0000000000000253
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA AQ4MB
UT WOS:000342770200001
PM 24670724
DA 2025-06-11
ER

PT J
AU Kawaguchi, Y
   Mizuta, T
AF Kawaguchi, Yasunori
   Mizuta, Toshihiko
TI Interaction between hepatitis C virus and metabolic factors
SO WORLD JOURNAL OF GASTROENTEROLOGY
LA English
DT Article
DE Hepatitis C virus; Insulin resistance; Diabetes; Lipid metabolism
   abnormality; Hepatic steatosis; Iron overload; Oxidative stress;
   Visceral obesity
ID INSULIN-RECEPTOR SUBSTRATE-1; SUSTAINED VIROLOGICAL RESPONSE; ACTIVATED
   PROTEIN-KINASE; GREEN TEA POLYPHENOLS; NECROSIS-FACTOR-ALPHA;
   HEPATOCELLULAR-CARCINOMA; DIABETES-MELLITUS; CORE PROTEIN;
   UP-REGULATION; GENOTYPE 1
AB Hepatitis C virus (HCV) infection disrupts the normal metabolism processes, but is also influenced by several of the host's metabolic factors. An obvious and significantly detrimental pathophysiological feature of HCV infection is insulin resistance in hepatic and peripheral tissues. Substantial research efforts have been put forth recently to elucidate the molecular mechanism of HCV-induced insulin resistance, and several cytokines, such as tumor necrosis factor-alpha, have been identified as important contributors to the development of insulin resistance in the distant peripheral tissues of HCV-infected patients and animal models. The demonstrated etiologies of HCV-induced whole-body insulin resistance include oxidative stress, lipid metabolism abnormalities, hepatic steatosis and iron overload. In addition, myriad effects of this condition have been characterized, including glucose intolerance, resistance to antiviral therapy, progression of hepatic fibrosis, development of hepatocellular carcinoma, and general decrease in quality of life. Metabolic-related conditions and disorders, such as visceral obesity and diabetes mellitus, have been shown to synergistically enhance HCV-induced metabolic disturbance, and are associated with worse prognosis. Yet, the molecular interactions between HCV-induced metabolic disturbance and host-associated metabolic factors remain largely unknown. The diet and lifestyle recommendations for chronic hepatitis C are basically the same as those for obesity, diabetes, and metabolic syndrome. Specifically, patients are suggested to restrict their dietary iron intake, abstain from alcohol and tobacco, and increase their intake of green tea and coffee(to attain the beneficial effects of caffeine and polyphenols). While successful clinical management of HCV-infected patients with metabolic disorders has also been achieved with some antidiabetic (i.e., metformin) and anti-lipid (i.e., statins) medications, it is recommended that sulfonylurea and insulin be avoided. (c) 2014 Baishideng Publishing Group Co., Limited. All rights reserved.
C1 [Kawaguchi, Yasunori; Mizuta, Toshihiko] Saga Med Sch, Dept Internal Med, Saga 8498501, Japan.
C3 Saga University
RP Kawaguchi, Y (corresponding author), Saga Med Sch, Dept Internal Med, 5-1-1 Nabeshima, Saga 8498501, Japan.
EM kawaguy@cc.saga-u.ac.jp
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NR 169
TC 51
Z9 53
U1 0
U2 17
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 7041 Koll Center Parkway, Suite 160, PLEASANTON, CA, UNITED STATES
SN 1007-9327
EI 2219-2840
J9 WORLD J GASTROENTERO
JI World J. Gastroenterol.
PD MAR 21
PY 2014
VL 20
IS 11
BP 2888
EP 2901
DI 10.3748/wjg.v20.i11.2888
PG 14
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA AE0PC
UT WOS:000333667200017
PM 24659880
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Moreno-Luna, R
   Muñoz-Hernandez, R
   Miranda, ML
   Costa, AF
   Jimenez-Jimenez, L
   Vallejo-Vaz, AJ
   Muriana, FJG
   Villar, J
   Stiefel, P
AF Moreno-Luna, Rafael
   Munoz-Hernandez, Rocio
   Miranda, Maria L.
   Costa, Alzenira F.
   Jimenez-Jimenez, Luis
   Vallejo-Vaz, Antonio J.
   Muriana, Francisco J. G.
   Villar, Jose
   Stiefel, Pablo
TI Olive Oil Polyphenols Decrease Blood Pressure and Improve Endothelial
   Function in Young Women with Mild Hypertension
SO AMERICAN JOURNAL OF HYPERTENSION
LA English
DT Article
DE blood pressure; endothelial dysfunction; endothelial function
   biomarkers; essential hypertension; hypertension; ischemia-reactive
   hyperemia (IRH); olive oil polyphenols
ID ASYMMETRIC DIMETHYLARGININE; CARDIOVASCULAR HEALTH; METABOLIC SYNDROME;
   OXIDATIVE STRESS; DARK CHOCOLATE; RISK; DISEASE; MEN; HUMANS; ADMA
AB BACKGROUND
   Olive oil polyphenols have been associated with several cardiovascular health benefits. This study aims to examine the influence of a polyphenol-rich olive oil on blood pressure (BP) and endothelial function in 24 young women with high-normal BP or stage 1 essential hypertension.
   METHODS
   We conducted a double-blind, randomized, crossover dietary-intervention study. After a run-in period of 4 months (baseline values), two diets were used, one with polyphenol-rich olive oil (similar to 30 mg/day), the other with polyphenol-free olive oil. Each dietary period lasted 2 months with a 4-week washout between diets. Systolic and diastolic BP, serum or plasma biomarkers of endothelial function, oxidative stress, and inflammation, and ischemia-induced hyperemia in the forearm were measured.
   RESULTS
   When compared to baseline values, only the polyphenol-rich olive oil diet led to a significant (P < 0.01) decrease of 7.91 mm Hg in systolic and 6.65 mm Hg of diastolic BP. A similar finding was found for serum asymmetric dimethylarginine (ADMA) (-0.09 0.01 mu mol/l, P < 0.01), oxidized low-density lipoprotein (ox-LDL) (-28.2 +/- 28.5 mu g/l, P < 0.01), and plasma C-reactive protein (CRP) (-1.9 +/- 1.3 mg/l, P < 0.001). The polyphenol-rich olive oil diet also elicited an increase in plasma nitrites/nitrates (+4.7 +/- 6.6 mu mol/l, P < 0.001) and hyperemic area after ischemia (+345 +/- 386 perfusion units (PU)/sec, P < 0.001).
   CONCLUSIONS
   We concluded that the consumption of a diet containing polyphenol-rich olive oil can decrease BP and improve endothelial function in young women with high-normal BP or stage 1 essential hypertension.
C1 [Moreno-Luna, Rafael; Munoz-Hernandez, Rocio; Miranda, Maria L.; Costa, Alzenira F.; Vallejo-Vaz, Antonio J.; Villar, Jose; Stiefel, Pablo] Univ Seville, Hosp Virgen del Rocio, Unidad Clin Expt Riesgo Vasc UCAMI UCERV, Inst Biomed Sevilla IBIS SAS,CEIC, Seville, Spain.
   [Jimenez-Jimenez, Luis] Hosp Virgen del Rocio, Serv Lab Clin, Seville, Spain.
   [Muriana, Francisco J. G.] CSIC, Inst Grasa, Lab Cellular & Mol Nutr, E-41080 Seville, Spain.
C3 Consejo Superior de Investigaciones Cientificas (CSIC); University of
   Sevilla; CSIC-JA-USE - Instituto de Biomedicina de Sevilla (IBIS);
   Virgen del Rocio University Hospital; Virgen del Rocio University
   Hospital; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC -
   Instituto de la Grasa (IG)
RP Stiefel, P (corresponding author), Univ Seville, Hosp Virgen del Rocio, Unidad Clin Expt Riesgo Vasc UCAMI UCERV, Inst Biomed Sevilla IBIS SAS,CEIC, Seville, Spain.
EM stiefel@cica.es
RI Muriana, Francisco/S-1825-2016; Vallejo-Vaz, Antonio/AAT-9301-2021;
   Stiefel García-Junco, Pablo/GSI-6577-2022; MORENO-LUNA,
   RAFAEL/AFP-3358-2022; Munoz-Hernandez, Rocio/S-5360-2016
OI Stiefel Garcia-Junco, Pablo Enrique/0000-0002-6668-5466; MORENO-LUNA,
   RAFAEL/0000-0002-9840-5078; Costa-Martins, Alzenira de
   Fatima/0000-0003-1788-743X; Munoz-Hernandez, Rocio/0000-0003-3765-6276;
   Vallejo-Vaz, Antonio J./0000-0001-7954-1253
FU CITOLIVA Foundation; Instituto de Salud Carlos III [RD06/0014/0035];
   Junta de Andalucia [CVI-4352]
FX This work was supported by CITOLIVA Foundation, Instituto de Salud
   Carlos III (RD06/0014/0035), and Junta de Andalucia (CVI-4352) grants.
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NR 42
TC 191
Z9 199
U1 0
U2 72
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0895-7061
EI 1941-7225
J9 AM J HYPERTENS
JI Am. J. Hypertens.
PD DEC
PY 2012
VL 25
IS 12
BP 1299
EP 1304
DI 10.1038/ajh.2012.128
PG 6
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 038LD
UT WOS:000311175300011
PM 22914255
OA Bronze, Green Accepted
DA 2025-06-11
ER

PT J
AU Baig, MR
   Navaira, E
   Escamilla, MA
   Raventos, H
   Walss-Bass, C
AF Baig, Muhammad R.
   Navaira, Erica
   Escamilla, Michael A.
   Raventos, Henriette
   Walss-Bass, Consuelo
TI Clozapine Treatment Causes Oxidation of Proteins Involved in Energy
   Metabolism in Lymphoblastoid Cells: A Possible Mechanism for
   Antipsychotic-Induced Metabolic Alterations
SO JOURNAL OF PSYCHIATRIC PRACTICE
LA English
DT Article
DE proteomics; oxidative stress; reactive oxygen species; glucose
   metabolism; clozapine; antipsychotics
ID DOUBLE-BLIND TRIAL; QUALITY-OF-LIFE; UMP-CMP KINASE; ATYPICAL
   ANTIPSYCHOTICS; 1ST-EPISODE PSYCHOSIS; RAT-BRAIN; INSULIN-RESISTANCE;
   MITOCHONDRIAL DYSFUNCTION; ANTIOXIDANT ENZYMES; LIPID-PEROXIDATION
AB There is increasing concern about the serious metabolic side effects and neurotoxicity caused by atypical (second-generation) antipsychotics. In a previous study by our group (Walss-Bass et al. Int J Neuropsychopharmacol 2008;11:1097-104), using a novel proteomic approach, we showed that clozapine treatment in SKNSH cells induces oxidation of proteins involved in energy metabolism, leading us to hypothesize that protein oxidation could be a mechanism by which atypical antipsychotics increase the risk for metabolic alterations. In this study, the same proteomic approach was used to identify specific proteins oxidized after clozapine treatment in lymphoblastoid cell lines from patients with schizophrenia and normal controls. Cells were treated with 0 and 20 mu M clozapine for 24 hrs and protein extracts were labeled with 6-iodoacetamide fluorescein (6-IAF). The lack of incorporation of 6-IAF into the thiol group of cysteine residues is an indicator of protein oxidation. Labeled proteins were exposed to two dimensional electrophoresis, and differential protein labeling was assessed. Increased oxidation after clozapine treatment was observed in 9 protein spots (p < 0.05). The following 7 proteins were identified by high-performance liquid chromatography-electrospray ionization tandem mass spectrometry (HPLC-ESI-MS/MS) in those 9 spots: enolase, triosephosphate isomerase (TPI), glyceraldehyde-3-phosphate dehydrogenase (GAPD), Rho GDP dissociation inhibitor (GDI), cofilin, uridine monophosphate/cytidine monophosphate (UMP-CMP) kinase, and translation elongation factor. Several of these proteins play important roles in energy metabolism and mitochondrial function. These results further support the hypothesis that oxidative stress may be a mechanism by which antipsychotics increase the risk of metabolic syndrome and diabetes. (Journal of Psychiatric Practice 2010;16:325-333)
C1 [Baig, Muhammad R.; Navaira, Erica; Walss-Bass, Consuelo] Univ Texas Hlth Sci Ctr San Antonio, Dept Psychiat, San Antonio, TX 78229 USA.
   [Escamilla, Michael A.] Texas Tech Univ, Hlth Sci Ctr, Paul L Foster Sch Med, El Paso, TX USA.
   [Escamilla, Michael A.] Texas Tech Univ, Hlth Sci Ctr, Ctr Excellence Neurosci, El Paso, TX USA.
   [Raventos, Henriette] Univ Costa Rica, Cellular & Mol Biol Res Ctr, San Jose, Costa Rica.
   [Raventos, Henriette] Univ Costa Rica, CIBCM, San Jose, Costa Rica.
C3 University of Texas System; University of Texas Health Science Center at
   San Antonio; Texas Tech University System; Texas Tech University Health
   Sciences Center El Paso; Texas Tech University; Texas Tech University
   System; Texas Tech University Health Sciences Center El Paso; Texas Tech
   University; Universidad Costa Rica; Universidad Costa Rica
RP Walss-Bass, C (corresponding author), Univ Texas Hlth Sci Ctr San Antonio, Dept Psychiat, 7703 Floyd Curl Dr, San Antonio, TX 78229 USA.
EM walss@uthscsa.edu
RI Raventos, Henriette/GVS-4816-2022; Walss-Bass, Consuelo/K-5702-2015
OI Raventos, Henriette/0000-0001-9423-8308; Walss-Bass,
   Consuelo/0000-0003-2474-5448
FU UTHSCSA Department of Psychiatry: Friends for Psychiatric Research and
   Stanley Medical Research Institute
FX Mass spectrometry analysis was performed by the UTHSCSA Mass
   Spectrometry Core Facility. We thank Kevin Hakala for his help with mass
   spectrometry analysis. This study was supported by grants to C.W-B. from
   UTHSCSA Department of Psychiatry: Friends for Psychiatric Research and
   Stanley Medical Research Institute.
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NR 56
TC 37
Z9 37
U1 0
U2 15
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1527-4160
J9 J PSYCHIATR PRACT
JI J. Psychiatr. Pract.
PD SEP
PY 2010
VL 16
IS 5
BP 325
EP 333
DI 10.1097/01.pra.0000388627.36781.6a
PG 9
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychiatry
GA 653ED
UT WOS:000282069900005
PM 20859109
OA Bronze
DA 2025-06-11
ER

PT J
AU Kosugi, T
   Nakayama, T
   Heinig, M
   Zhang, L
   Yuzawa, Y
   Sanchez-Lozada, LG
   Roncal, C
   Johnson, RJ
   Nakagawa, T
AF Kosugi, Tomoki
   Nakayama, Takahiro
   Heinig, Marcelo
   Zhang, Li
   Yuzawa, Yukio
   Sanchez-Lozada, Laura Gabriela
   Roncal, Carlos
   Johnson, Richard J.
   Nakagawa, Takahiko
TI Effect of lowering uric acid on renal disease in the type 2 diabetic
   db/db mice
SO AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
LA English
DT Article
DE inflammation; monocyte chemoattractant protein-1; intercellular adhesion
   molecule-1
ID INDUCED METABOLIC SYNDROME; BLOOD-PRESSURE; INDEPENDENT MECHANISM;
   OXIDATIVE STRESS; KNOCKOUT MICE; NEPHROPATHY; HYPERURICEMIA;
   ALLOPURINOL; INJURY; PROGRESSION
AB Kosugi T, Nakayama T, Heinig M, Zhang L, Yuzawa Y, Sanchez-Lozada LG, Roncal C, Johnson RJ, Nakagawa T. Effect of lowering uric acid on renal disease in the type 2 diabetic db/db mice. Am J Physiol Renal Physiol 297: F481-F488, 2009. First published May 20, 2009; doi:10.1152/ajprenal.00092.2009.-Hyperuricemia has recently been recognized to be a risk factor for nephropathy in the diabetic subject. We tested the hypothesis that lowering uric acid with a xanthine oxidase inhibitor might reduce renal injury in the diabetic mouse. Diabetic (db/db) mice were treated with allopurinol or no treatment for 8 wk. Serum uric acid, renal function, and histology were assessed at death. The direct effect of uric acid in human proximal tubular epithelial cells was also evaluated under normal or high glucose condition. We found that db/db mice developed hyperuricemia, albuminuria, mesangial matrix expansion, and mild tubulointerstitial disease. Allopurinol treatment significantly lowered uric acid levels, reduced albuminuria, and ameliorated tubulointerstitial injury, but it did not prevent mesangial expansion. The mechanism for protection was shown to be due to a reduction in inflammatory cells mediated by a reduction in ICAM-1 expression by tubular epithelial cells. Interestingly, allopurinol did not reduce oxidative stress in the kidney. An inflammatory role of uric acid on tubular cells was also confirmed by our in vitro evidence that uric acid directly induced ICAM-1 expression in the human proximal tubular cell. In conclusion, hyperuricemia has a pathogenic role in the mild tubulointerstitial injury associated with diabetic nephropathy but not glomerular damage in db/db mice. Lowering uric acid may reduce tubulointerstitial injury in diabetes.
C1 [Sanchez-Lozada, Laura Gabriela; Roncal, Carlos; Johnson, Richard J.; Nakagawa, Takahiko] Univ Colorado Denver, Div Renal Dis & Hypertens, Aurora, CO 80045 USA.
   [Kosugi, Tomoki; Nakayama, Takahiro; Heinig, Marcelo; Sanchez-Lozada, Laura Gabriela; Roncal, Carlos; Johnson, Richard J.; Nakagawa, Takahiko] Univ Florida, Div Nephrol, Gainesville, FL USA.
   [Zhang, Li] Univ Florida, Mol Pathol & Immunol Core Lab, Gainesville, FL USA.
   [Yuzawa, Yukio] Nagoya Univ, Grad Sch Med, Dept Nephrol Internal Med, Nagoya, Aichi 4648601, Japan.
C3 Children's Hospital Colorado; University of Colorado System; University
   of Colorado Anschutz Medical Campus; State University System of Florida;
   University of Florida; State University System of Florida; University of
   Florida; Nagoya University
RP Nakagawa, T (corresponding author), Univ Colorado Denver, Div Renal Dis & Hypertens, C281, Aurora, CO 80045 USA.
EM takahiko.nakagawa@ucdenver.edu
RI Sanchez-Lozada, Laura/AAS-2104-2021; Nakayama, Takahiro/AAE-8953-2019
OI Sanchez-Lozada, Laura-Gabriela/0000-0003-0348-9617
FU Juvenile Diabetes Research Foundation; National Institute of Diabetes
   and Digestive and Kidney Diseases [DK-52121]; National Heart, Lung, and
   Blood Institute [HL-68607]; Gatorade
FX This study was supported by the Juvenile Diabetes Research Foundation,
   by National Institute of Diabetes and Digestive and Kidney Diseases
   Grant DK-52121, by National Heart, Lung, and Blood Institute Grant
   HL-68607, and by generous funds from Gatorade.
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NR 35
TC 152
Z9 162
U1 1
U2 22
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 1931-857X
EI 1522-1466
J9 AM J PHYSIOL-RENAL
JI Am. J. Physiol.-Renal Physiol.
PD AUG
PY 2009
VL 297
IS 2
BP F481
EP F488
DI 10.1152/ajprenal.00092.2009
PG 8
WC Physiology; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology; Urology & Nephrology
GA 474IF
UT WOS:000268276300028
PM 19458127
OA Green Published
DA 2025-06-11
ER

PT J
AU Wei, Y
   Sowers, JR
   Clark, SE
   Li, W
   Ferrario, CM
   Stump, CS
AF Wei, Yongzhong
   Sowers, James R.
   Clark, Suzanne E.
   Li, Wenhan
   Ferrario, Carlos M.
   Stump, Craig S.
TI Angiotensin II-induced skeletal muscle insulin resistance mediated by
   NF-κB activation via NADPH oxidase
SO AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
LA English
DT Article
DE nuclear factor-kappa B; reduced nicotinamide adenine dinucleotide
   phosphate; renin-angiotensin system; reactive oxygen species;
   TG(mRen2)27 rat; tumor necrosis factor-alpha; angiotensin receptor
   blocker
ID TYPE-2 DIABETES-MELLITUS; OXIDATIVE STRESS; REACTIVE OXYGEN; METABOLIC
   SYNDROME; INHIBITION; HYPERTENSION; CELLS; RAT; PATHOGENESIS;
   INFLAMMATION
AB Reduced insulin sensitivity is a key factor in the pathogenesis of type 2 diabetes and hypertension. Skeletal muscle insulin resistance is particularly important for its major role in insulin-mediated glucose disposal. Angiotensin II (ANG II) is integral in regulating blood pressure and plays a role in the pathogenesis of hypertension. In addition, we have documented that ANG II-induced skeletal muscle insulin resistance is associated with generation of reactive oxygen species (ROS). However, the linkage between ROS and insulin resistance in skeletal muscle remains unclear. To explore potential mechanisms, we employed the transgenic TG(mRen2) 27 (Ren-2) hypertensive rat, which harbors the mouse renin transgene and exhibits elevated tissue ANG II levels, and skeletal muscle cell culture. Compared with Sprague-Dawley normtensive control rats, Ren-2 skeletal muscle exhibited significantly increased oxidative stress, NF-kappa B activation, and TNF-alpha expression, which were attenuated by in vivo treatment with an angiotensin type 1 receptor blocker (valsartan) or SOD/catalase mimetic (tempol). Moreover, ANG II treatment of L6 myotubes induced NF-kappa B activation and TNF-alpha production and decreased insulin-stimulated Akt activation and GLUT-4 glucose transporter translocation to plasma membranes. These effects were markedly diminished by treatment of myotubes with valsartan, the antioxidant N-acetylcysteine, NADPH oxidase-inhibiting peptide (gp91 ds-tat), or NF-kappa B inhibitor (MG-132). Similarly, NF-kappa B p65 small interfering RNA reduced NF-kappa B p65 subunit expression and nuclear translocation and TNF-alpha production but improved insulin-stimulated phosphorylation (Ser(473)) of Akt and translocation of GLUT-4. These findings suggest that NF-kappa B plays an important role in ANG II/ROS-induced skeletal muscle insulin resistance.
C1 Univ Arizona, Diabet Res Program, Dept Med, Tucson, AZ 85724 USA.
   [Stump, Craig S.] So Arizona Vet Affairs Hlth Care Syst, Tucson, AZ 85724 USA.
   [Wei, Yongzhong; Sowers, James R.; Clark, Suzanne E.; Li, Wenhan] Univ Missouri, Dept Internal Med, Columbia, MO 65211 USA.
   [Wei, Yongzhong; Sowers, James R.; Clark, Suzanne E.; Li, Wenhan] Harry S Truman Mem Affairs Med Ctr, Columbia, MO USA.
   [Ferrario, Carlos M.] Wake Forest Univ, Sch Med, Winston Salem, NC USA.
C3 University of Arizona; US Department of Veterans Affairs; Veterans
   Health Administration (VHA); Southern Arizona Veterans Affairs Health
   Care System; University of Missouri System; University of Missouri
   Columbia; US Department of Veterans Affairs; Veterans Health
   Administration (VHA); Harry S. Truman Memorial Veterans' Hospital; Wake
   Forest University
RP Stump, CS (corresponding author), Univ Arizona, Diabet Res Program, Dept Med, POB 245218, Tucson, AZ 85724 USA.
EM cstump@deptofmed.arizona.edu
RI Ferrario, Carlos/ABD-2791-2020
OI Ferrario, Carlos M/0000-0003-0792-6239
FU NHLBI NIH HHS [R01 HL 073101-02] Funding Source: Medline
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NR 32
TC 160
Z9 184
U1 0
U2 7
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0193-1849
J9 AM J PHYSIOL-ENDOC M
JI Am. J. Physiol.-Endocrinol. Metab.
PD FEB
PY 2008
VL 294
IS 2
BP E345
EP E351
DI 10.1152/ajpendo.00456.2007
PG 7
WC Endocrinology & Metabolism; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Physiology
GA 261KN
UT WOS:000253077600017
PM 18073321
DA 2025-06-11
ER

PT J
AU Bui, VT
   Wu, KW
   Chen, CC
   Nguyen, AT
   Huang, WJ
   Lee, LY
   Chen, WP
   Huang, CY
   Shiao, YJ
AF Bui, Van Thanh
   Wu, Kuan-Wei
   Chen, Chin-Chu
   Nguyen, Anh Thuc
   Huang, Wei-Jan
   Lee, Li-Ya
   Chen, Wan-Ping
   Huang, Chi-Ying
   Shiao, Young-Ji
TI Exploring the Synergistic Effects of Erinacines on Microglial Regulation
   and Alzheimer's Pathology Under Metabolic Stress
SO CNS NEUROSCIENCE & THERAPEUTICS
LA English
DT Article
DE Alzheimer's disease; erinacines; Hericium erinaceus; metabolic stress;
   microglia; neuroinflammation
ID INSULIN-RESISTANCE; DISEASE; ORIGIN; NEUROINFLAMMATION; AUGMENTATION;
   RAMIFICATION; PARENCHYMA; RISK
AB Background: Hericium erinaceus mycelium and its constituents, erinacines A and S, have shown neuroprotective effects in APP/PS1 transgenic mice; however, the precise mechanisms by which they modulate microglial phenotypes remain unclear. Our study is the first to explore the effect of erinacines on microglia morphology and the underlying mechanisms using a novel primary mixed glia cell model and advanced bioinformatic tools. Furthermore, we emphasize the clinical relevance by evaluating erinacines in a metabolically stressed APP/PS1 mouse model, which more accurately reflects the complexities of human Alzheimer's disease (AD), where metabolic syndrome is a common comorbidity. Methods: Rat primary mixed glial cultures were used to simulate the spectrum of microglial phenotypes, particularly the transition from immature to mature states. Microarray sequencing, along with Connectivity Map, ConsensusPathDB, and Gene Set Enrichment Analysis, identified pathways influenced by erinacines. The therapeutic efficacy was further evaluated in metabolically stressed APP/PS1 mice. Results: Erinacines significantly promoted the development of a ramified, neuroprotective microglial phenotype. Bioinformatics revealed potential modulation of microglia via histone deacetylase inhibition, actin filament dynamics, and synaptic structure modification-pathways not previously linked to erinacines in AD. Importantly, erinacines significantly lower fasting blood glucose and insulin levels while reducing amyloid-beta plaque burden, suppressing hyperactivated glial responses, and enhancing neurogenesis in the metabolically stressed APP/PS1 mice. Conclusion: Our findings demonstrate the dual action of erinacines in modulating microglia morphology and phenotype while providing neuroprotection in a model that closely mimic the complexities of human Alzheimer's disease. Additionally, this study provides the foundation for understanding the potential mechanisms of action of erinacines, highlighting their promise as a novel treatment approach for Alzheimer's, particularly in cases complicated by metabolic dysfunction.
C1 [Bui, Van Thanh; Wu, Kuan-Wei; Nguyen, Anh Thuc; Huang, Chi-Ying; Shiao, Young-Ji] Natl Yang Ming Chiao Tung Univ, Inst Biopharmaceut Sci, Taipei, Taiwan.
   [Bui, Van Thanh; Nguyen, Anh Thuc; Huang, Chi-Ying] Natl Yang Ming Chiao Tung Univ, Acad Sinica, Taiwan Natl Grad Program Mol Med, Taipei, Taiwan.
   [Chen, Chin-Chu; Lee, Li-Ya; Chen, Wan-Ping] Grape King Bio Ltd, Taoyuan City, Taiwan.
   [Huang, Wei-Jan; Shiao, Young-Ji] Taipei Med Univ, PhD Program Biotechnol Res & Dev, Taipei, Taiwan.
   [Huang, Chi-Ying] Kaohsiung Med Univ, Coll Med, Dept Biochem, Kaohsiung, Taiwan.
   [Huang, Chi-Ying] Natl Yang Ming Chiao Tung Univ, Chong Hin Loon Mem Canc & Biotherapy Res Ctr, Taipei, Taiwan.
   [Shiao, Young-Ji] Minist Hlth & Welf, Natl Res Inst Chinese Med, Taipei, Taiwan.
C3 National Yang Ming Chiao Tung University; National Yang Ming Chiao Tung
   University; Academia Sinica - Taiwan; Taipei Medical University;
   Kaohsiung Medical University; National Yang Ming Chiao Tung University;
   National Research Institute of Chinese Medicine
RP Huang, CY; Shiao, YJ (corresponding author), Natl Yang Ming Chiao Tung Univ, Inst Biopharmaceut Sci, Taipei, Taiwan.; Huang, CY (corresponding author), Natl Yang Ming Chiao Tung Univ, Acad Sinica, Taiwan Natl Grad Program Mol Med, Taipei, Taiwan.; Shiao, YJ (corresponding author), Taipei Med Univ, PhD Program Biotechnol Res & Dev, Taipei, Taiwan.; Huang, CY (corresponding author), Kaohsiung Med Univ, Coll Med, Dept Biochem, Kaohsiung, Taiwan.; Huang, CY (corresponding author), Natl Yang Ming Chiao Tung Univ, Chong Hin Loon Mem Canc & Biotherapy Res Ctr, Taipei, Taiwan.; Shiao, YJ (corresponding author), Minist Hlth & Welf, Natl Res Inst Chinese Med, Taipei, Taiwan.
EM cyhuang5@nycu.edu.tw; yshiao@nricm.edu.tw
RI Huang, JianJang/A-1743-2012; Shiao, Young-Ji/AAA-9647-2022; Huang,
   Chi-Ying/AFL-7729-2022
OI Shiao, Young-Ji/0000-0002-2699-116X; Huang, Chi-Ying
   F/0000-0003-4898-4937
FU National Science and Technology Council; Biotechnology Centre, Grape
   King Bio Ltd.;  [MOST109-2622-B-010-004-CC1];  [MOST111-2320-B-077-003]
FX The design of the study was supported by the Biotechnology Centre, Grape
   King Bio Ltd. Chung-Li, Taoyuan 320, Taiwan, R.O.C. The collection,
   analysis, and interpretation of data and manuscript writing of this
   study were supported by the National science and Technology Council
   (MOST109-2622-B-010-004-CC1; MOST111-2320-B-077-003).
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NR 48
TC 2
Z9 2
U1 8
U2 8
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1755-5930
EI 1755-5949
J9 CNS NEUROSCI THER
JI CNS Neurosci. Ther.
PD DEC
PY 2024
VL 30
IS 12
AR e70137
DI 10.1111/cns.70137
PG 24
WC Neurosciences; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pharmacology & Pharmacy
GA P8F8A
UT WOS:001380207800001
PM 39690860
OA gold
DA 2025-06-11
ER

PT J
AU Moore, JX
   Bevel, MS
   Aslibekyan, S
   Akinyemiju, T
AF Moore, Justin Xavier
   Bevel, Malcolm S.
   Aslibekyan, Stella
   Akinyemiju, Tomi
TI Temporal changes in allostatic load patterns by age, race/ethnicity, and
   gender among the US adult population; 1988?2018
SO PREVENTIVE MEDICINE
LA English
DT Article
DE Life-course; Cumulative stress; Psychosocial stress; Race; Disparities
ID AMBULATORY BLOOD-PRESSURE; NUTRITION EXAMINATION SURVEY; CUMULATIVE
   BIOLOGICAL RISK; ALL-CAUSE MORTALITY; SOCIOECONOMIC-STATUS;
   NATIONAL-HEALTH; RESIDENTIAL SEGREGATION; CARDIOVASCULAR-DISEASE; RACIAL
   DISPARITIES; METABOLIC SYNDROME
AB The objective of this study is to provide an assessment of allostatic load (AL) burden among US adults across race/ethnicity, gender, and age groups over a 30-year time period. We analyzed data from 50,671 participants of the National Health and Nutrition Examination Survey (NHANES) years 1988 through 2018. AL score was defined as the sum total for abnormal measures of the following components: serum albumin, body mass index, serum C ? reactive protein, serum creatinine, diastolic blood pressure, glycated hemoglobin, systolic blood pressure, total cholesterol, and serum triglycerides. We performed modified Poisson regression to estimate the adjusted Relative Risks (aRRs) of allostatic load, and generalized linear models to determine adjusted mean differences accounting for NHANES sampling weights. Among US adults aged 18 or older, the prevalence of high AL increased by more than 45% from 1988 to 1991 to 2015?2018, from 33.5% to 48.6%. By the latest period, 2015?2018, Non-Hispanic Black women (aRR: 1.292; 95% CI: 1.290?1.293) and Latina women (aRR: 1.266; 95% CI: 1.265?1.267) had higher risks of AL than non-Hispanic White women. Similar trends were observed among men. Age-adjusted mean AL score among NH-Black and Latinx adults was higher than for NH-Whites of up to a decade older regardless of gender. From 1988 through 2018, Adults aged 40 years old and older had over 2-fold increased risks of high AL when compared to adults 18?29 years old. After 30-years of collective data, racial disparities in allostatic load persist for NH-Black and Latinx adults.
C1 [Moore, Justin Xavier] Augusta Univ, Dept Populat Hlth Sci, Div Epidemiol, Augusta, GA USA.
   [Moore, Justin Xavier] Augusta Univ, Med Coll Georgia, Inst Prevent & Publ Hlth, Augusta, GA USA.
   [Bevel, Malcolm S.; Akinyemiju, Tomi] Duke Univ, Dept Populat Hlth Sci, Sch Med, Durham, NC 27708 USA.
   [Aslibekyan, Stella] Univ Alabama Birmingham, Dept Epidemiol, Birmingham, AL USA.
C3 University System of Georgia; Augusta University; University System of
   Georgia; Augusta University; Duke University; University of Alabama
   System; University of Alabama Birmingham
RP Akinyemiju, T (corresponding author), Duke Univ, Dept Populat Hlth Sci, Sch Med, Durham, NC 27708 USA.
EM tomi.akinyemiju@duke.edu
FU National Institute on Minority Health And Health Disparities of the
   National Institutes of Health [K01MD015304]; National Cancer Institute
   of the National Institutes of Health [K01TW010271]
FX Dr. Moore was supported by the National Institute on Minority Health And
   Health Disparities of the National Institutes of Health under Award
   Number K01MD015304. Dr. Akinyemiju was supported by National Cancer
   Institute of the National Institutes of Health under award number
   K01TW010271. The content is solely the responsibility of the authors and
   does not necessarily represent the official views of the National
   Institutes of Health.
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NR 88
TC 33
Z9 39
U1 1
U2 10
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0091-7435
EI 1096-0260
J9 PREV MED
JI Prev. Med.
PD JUN
PY 2021
VL 147
AR 106483
DI 10.1016/j.ypmed.2021.106483
EA MAR 2021
PG 10
WC Public, Environmental & Occupational Health; Medicine, General &
   Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; General & Internal Medicine
GA RV1TC
UT WOS:000645622200010
PM 33640399
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Bin-Meferij, MM
   Shati, AA
   Eid, RA
   El-Kott, AF
AF Bin-Meferij, Mashael Mohammed
   Shati, Ali Abdullah
   Eid, Refaat Ali
   El-Kott, Attalla Farag
TI Anti-obesity and Anti-hepatosteatosis Effects of Dietary Zingiber
   officinale Extract in Male Obese Rats
SO INTERNATIONAL JOURNAL OF PHARMACOLOGY
LA English
DT Article
DE Obesity; Zingiber ofiticinale; high fat diet; anti-oxidants;
   hepatosteatosis; hyperlipidemia
ID METABOLIC SYNDROME; GINGER; CHITOSAN; RHIZOME; ROSCOE; MICE; MASS
AB Background and Objective: Obesity is a chronic, multifactorial disease that develops from the interaction of behavioral, physiological, metabolic, cellular and molecular factors. High fat diet produces a consistent and significant increase (p<0.05) in body fat content which is dependent on both the amount of fat in the diet and the duration of feeding. So, this study was aimed to investigate the effects of ginger extract on obesity and hepatosteatosis in obese rats-induced by high fat diet and its capability of antioxidants-rich ginger extract in protecting rats against obesity complications. Materials and Methods: The study continued for eight weeks and the animal groups consisted of 80 male Wistar rats which were distributed equally among four groups. Body and fat weight, hepatic enzymes, anti-oxidant enzymes, oxidative stress marker, lipid profile, hepatic histopathological and ultrastructure investigations were recorded. Results: High Fat Diet (HFD) treated group exhibited a significant decrease (p<0.05) in antioxidant enzymes and High-Density Lipoprotein (HDL). Also, subjects in this group exhibited a significant increase (p<0.05) in liver enzymes, malondialdehyde (MDA), Total Cholesterol (TC) and triglycerides (TG). Additionally, concurrent exposure to HFD and treated with ginger extract significantly showed the protective potential of ginger extract in restoring the altered antioxidants, lipid profile and other biochemical analysis. Furthermore, Rats treated with HFD and protected with ginger extract improved the histopathological changes induced in the liver by obesity and showed that the hepatocytes with normal nucleus, large number of mitochondria and well developed Rough Endoplasmic Reticulum (RER) reflected the activity of the cell to produce high amount of proteins needed for normal differentiation. Conclusion: The extract of ginger showed noteworthy protection from the HFD-induced metabolic disturbances by strongly suppressing the body weight gain, oxidative stress and hyperlipidemia. Thus the present findings emphasize that the rhizome of Z. officinale possesses potential medicinal values.
C1 [Bin-Meferij, Mashael Mohammed] Princess Nourah Bint Abdulrahman Univ, Dept Biol, Riyadh, Saudi Arabia.
   [Shati, Ali Abdullah] King Khalid Univ, Coll Sci, Dept Biol, Abha, Saudi Arabia.
   [Eid, Refaat Ali] King Khalid Univ, Coll Med, Dept Pathol, Abha, Saudi Arabia.
   [El-Kott, Attalla Farag] King Khalid Univ, Sci Res, Abha, Saudi Arabia.
   [El-Kott, Attalla Farag] Damanhour Univ, Fac Sci, Dept Zool, Damanhour, Egypt.
C3 Princess Nourah bint Abdulrahman University; King Khalid University;
   King Khalid University; King Khalid University; Egyptian Knowledge Bank
   (EKB); Damanhour University
RP El-Kott, AF (corresponding author), King Khalid Univ, Sci Res, Abha, Saudi Arabia.
RI Shati, Ali/J-8491-2012; Eid, Refaat/HTM-2441-2023; Bin-Meferij,
   Mashael/HJB-1103-2022; El-kott, Attalla/D-1971-2017
OI Bin-Meferij, Mashael/0000-0002-0109-530X; El-kott,
   Attalla/0000-0001-5060-0790; Eid, Refaat/0000-0001-5633-9562; Shati,
   Ali/0000-0003-1800-7238
FU Deanship of Scientific Research, Princess Nourah bint Abdulrahman
   University, Saudi Arabia [162/37]
FX The authors thank Deanship of Scientific Research, Princess Nourah bint
   Abdulrahman University, Saudi Arabia, for the financial support to
   complete this study (Grant No. 162/37).
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U2 11
PU ASIAN NETWORK SCIENTIFIC INFORMATION-ANSINET
PI FAISALABAD
PA 308-LASANI TOWN, SARGODHA RD, FAISALABAD, 38090, PAKISTAN
SN 1811-7775
EI 1812-5700
J9 INT J PHARMACOL
JI Int. J. Pharmacol.
PY 2017
VL 13
IS 6
BP 620
EP 627
DI 10.3923/ijp.2017.620.627
PG 8
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA FA6WV
UT WOS:000405586400012
OA Bronze
DA 2025-06-11
ER

PT J
AU Lytle, KA
   Jump, DB
AF Lytle, Kelli A.
   Jump, Donald B.
TI Is Western Diet-Induced Nonalcoholic Steatohepatitis in
   Ldlr<SUP>-/-</SUP> Mice Reversible?
SO PLOS ONE
LA English
DT Article
ID FATTY LIVER-DISEASE; HEPATIC GENE-EXPRESSION; TOLL-LIKE RECEPTORS;
   STELLATE CELLS; MOUSE MODEL; FIBROSIS; INFLAMMATION; RESOLUTION;
   EPIDEMIOLOGY; FIBROGENESIS
AB Background
   Nonalcoholic fatty liver disease (NAFLD) is a major public health burden in western societies. The progressive form of NAFLD, nonalcoholic steatohepatitis (NASH), is characterized by hepatosteatosis, inflammation, oxidative stress, and hepatic damage that can progress to fibrosis and cirrhosis; risk factors for hepatocellular carcinoma. Given the scope of NASH, validating treatment protocols (i.e., low fat diets and weight loss) is imperative.
   Methods
   We evaluated the efficacy of two diets, a non-purified chow (NP) and purified (low-fat low-cholesterol, LFLC) diet to reverse western diet (WD)-induced NASH and fibrosis in Ldlr(-/-) mice.
   Results
   Mice fed WD for 22-24 weeks developed robust hepatosteatosis with mild fibrosis, while mice maintained on the WD an additional 7-8 weeks developed NASH with moderate fibrosis. Returning WD-fed mice to the NP or LFLC diets significantly reduced body weight and plasma markers of metabolic syndrome (dyslipidemia, hyperglycemia) and hepatic gene expression markers of inflammation (Mcp1), oxidative stress (Nox2), fibrosis (Col1A, LoxL2, Timp1) and collagen crosslinking (hydroxyproline). Time course analyses established that plasma triglycerides and hepatic Col1A1 mRNA were rapidly reduced following the switch from the WD to the LFLC diet. However, hepatic triglyceride content and fibrosis did not return to normal levels 8 weeks after the change to the LFLC diet. Time course studies further revealed a strong association (r(2) >= 0.52) between plasma markers of inflammation (TLR2 activators) and hepatic fibrosis markers (Col1A, Timp1, LoxL2). Inflammation and fibrosis markers were inversely associated (r(2) >= 0.32) with diet-induced changes in hepatic omega 3 and omega 6 polyunsaturated fatty acids (PUFA) content.
   Conclusion
   These studies establish a temporal link between plasma markers of inflammation and hepatic PUFA and fibrosis. Low-fat low-cholesterol diets promote reversal of many, but not all, features associated with WD-induced NASH and fibrosis in Ldlr(-/-) mice.
C1 [Lytle, Kelli A.; Jump, Donald B.] Oregon State Univ, Sch Biol & Populat Hlth Sci, Nutr Program, Corvallis, OR 97331 USA.
   [Lytle, Kelli A.; Jump, Donald B.] Oregon State Univ, Linus Pauling Inst, Corvallis, OR 97331 USA.
C3 Oregon State University; Oregon State University
RP Jump, DB (corresponding author), Oregon State Univ, Sch Biol & Populat Hlth Sci, Nutr Program, Corvallis, OR 97331 USA.
EM Donald.Jump@oregonstate.edu
FU NIH [DK094600]; USDA National Institute of Food and Agriculture Grant
   [2009-65200-05846]; NIFA [581537, 2009-65200-05846] Funding Source:
   Federal RePORTER
FX This work was supported by NIH DK094600 and USDA National Institute of
   Food and Agriculture Grant (2009-65200-05846).
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NR 58
TC 33
Z9 35
U1 0
U2 7
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JAN 13
PY 2016
VL 11
IS 1
AR e0146942
DI 10.1371/journal.pone.0146942
PG 24
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA DA8CX
UT WOS:000368033100056
PM 26761430
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Macconi, D
   Perico, L
   Longaretti, L
   Morigi, M
   Cassis, P
   Buelli, S
   Perico, N
   Remuzzi, G
   Benigni, A
AF Macconi, Daniela
   Perico, Luca
   Longaretti, Lorena
   Morigi, Marina
   Cassis, Paola
   Buelli, Simona
   Perico, Norberto
   Remuzzi, Giuseppe
   Benigni, Ariela
TI Sirtuin3 Dysfunction Is the Key Determinant of Skeletal Muscle Insulin
   Resistance by Angiotensin II
SO PLOS ONE
LA English
DT Article
ID ACTIVATED PROTEIN-KINASE; METABOLIC SYNDROME; L-CARNITINE; GLUT4
   TRANSLOCATION; OXIDATIVE STRESS; GLUCOSE-UPTAKE; NADPH OXIDASE;
   MITOCHONDRIAL; EXPRESSION; AMPK
AB Background
   Angiotensin II promotes insulin resistance. The mechanism underlying this abnormality, however, is still poorly defined. In a different setting, skeletal muscle metabolism and insulin signaling are regulated by Sirtuin3.
   Objective
   Here, we investigate whether angiotensin II-induced insulin resistance in skeletal muscle is associated with Sirtuin3 dysregulation and whether pharmacological manipulation of Sirtuin3 confers protection.
   Study Design
   Parental and GLUT4-myc L6 rat skeletal muscle cells exposed to angiotensin II are used as in vitro models of insulin resistance. GLUT4 translocation, glucose uptake, intracellular molecular signals such as mitochondrial reactive oxygen species, Sirtuin3 protein expression and activity, along with its downstream targets and upstream regulators, are analyzed both in the absence and presence of acetyl-L-carnitine. The role of Sirtuin3 in GLUT4 translocation and intracellular molecular signaling is also studied in Sirtuin3-silenced as well as overexpressing cells.
   Results
   Angiotensin II promotes insulin resistance in skeletal muscle cells via mitochondrial oxidative stress, resulting in a two-fold increase in superoxide generation. In this context, reactive oxygen species open the mitochondrial permeability transition pore and significantly lower Sirtuin3 levels and activity impairing the cell antioxidant defense. Angiotensin II-induced Sirtuin3 dysfunction leads to the impairment of AMP-activated protein kinase/nicotinamide phosphoribosyltransferase signaling. Acetyl-L-carnitine, by lowering angiotensin II-induced mitochondrial superoxide formation, prevents Sirtuin3 dysfunction. This phenomenon implies the restoration of manganese superoxide dismutase antioxidant activity and AMP-activated protein kinase activation. Acetyl-L-carnitine protection is abrogated by specific Sirtuin3 siRNA.
   Conclusions
   Our data demonstrate that angiotensin II-induced insulin resistance fosters mitochondrial superoxide generation, in turn leading to Sirtuin3 dysfunction. The present results also highlight Sirtuin3 as a therapeutic target for the insulin-sensitizing effects of acetyl-L-carnitine.
C1 [Macconi, Daniela; Perico, Luca; Longaretti, Lorena; Morigi, Marina; Buelli, Simona; Remuzzi, Giuseppe; Benigni, Ariela] IRCCS, Ist Ric Farmacol Mario Negri, Ctr Anna Maria Astori, I-24126 Bergamo, Italy.
   [Cassis, Paola; Perico, Norberto] IRCCS, Ist Ric Farmacol Mario Negri, Clin Res Ctr Rare Dis Aldo & Cele Dacco, I-24020 Bergamo, Italy.
   [Remuzzi, Giuseppe] Azienda Osped Papa Giovanni XXIII, Unit Nephrol & Dialysis, I-24127 Bergamo, Italy.
C3 Istituto di Ricerche Farmacologiche Mario Negri IRCCS; Istituto di
   Ricerche Farmacologiche Mario Negri IRCCS; ASST Papa Giovanni XXIII
RP Macconi, D (corresponding author), IRCCS, Ist Ric Farmacol Mario Negri, Ctr Anna Maria Astori, Sci & Technol Pk Kilometro Rosso,Via Stezzano 87, I-24126 Bergamo, Italy.
EM daniela.macconi@marionegri.it
RI Perico, Norberto/ABH-3222-2020; Morigi, Marina/ABH-3131-2020; Macconi,
   Daniela/ABH-3534-2020; Ariela, Benigni/ABH-3492-2020; Buelli,
   Simona/AAB-1847-2020; Longaretti, Lorena/ABG-1258-2020; Perico,
   Luca/ABH-3224-2020; Remuzzi, Giuseppe/V-9766-2017
OI Benigni, Ariela/0000-0002-4721-5485; Buelli, Simona/0000-0002-2508-7793;
   , Macconi Daniela/0000-0002-2208-9646; Perico,
   Norberto/0000-0002-3147-4327; Morigi, Marina/0000-0001-8029-7382;
   Remuzzi, Giuseppe/0000-0002-6194-3446; Perico, Luca/0000-0003-3470-1721
FU fiRSt Srl, Rome, Italy
FX The study was supported by a grant from fiRSt Srl, Rome, Italy.
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NR 59
TC 15
Z9 16
U1 1
U2 9
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAY 19
PY 2015
VL 10
IS 5
AR e0127172
DI 10.1371/journal.pone.0127172
PG 17
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA CI7BT
UT WOS:000354918600052
PM 25993470
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Han, JY
   Tan, C
   Wang, YH
   Yang, SB
   Tan, DH
AF Han, Junyan
   Tan, Chang
   Wang, Yiheng
   Yang, Shaobin
   Tan, Dehong
TI Betanin reduces the accumulation and cross-links of collagen in
   high-fructose-fed rat heart through inhibiting non-enzymatic glycation
SO CHEMICO-BIOLOGICAL INTERACTIONS
LA English
DT Article
DE Diabetic cardiomyopathy; NF-kappa B; Methylglyoxal; AGEs; Insulin
ID END-PRODUCTS; DIABETIC CARDIOMYOPATHY; GLUTATHIONE-PEROXIDASE; CARDIAC
   DYSFUNCTION; METABOLIC SYNDROME; RED BEET; EXTRACT; PROTEIN; ACID; MICE
AB We attempted to determine whether betanin (from natural pigments) that has antioxidant properties would be protective against fructose-induced diabetic cardiac fibrosis in Sprague-Dawley rats. Fructose water solution (30%) was accessed freely, and betanin (25 and 100 mg/kg/d) was administered by intragastric gavage continuously for 60 d. Rats were sacrificed after overnight fast. The rat blood and left ventricle were collected. In vitro antiglycation assay in bovine serum albumin/fructose system was also performed. In rats treated only with fructose, levels of plasma markers: glucose, insulin, HOMA and glycated hemoglobin rised, left ventricle collagen accumulated and cross-linked, profibrotic factor-transforming growth factor (TGF)-beta 1 and connective tissue growth factor (CTGF) protein expression increased, and soluble collagen decreased, compared with those in normal rats, showing fructose induces diabetic cardiac fibrosis. Treatment with betanin antagonized the changes of these parameters, demonstrating the antifibrotic role of betanin in the selected diabetic models. In further mechanistic study, betanin decreased protein glycation indicated by the decreased levels of protein glycation reactive intermediate (methylglyoxal), advanced glycation end product (N-epsilon-(carboxymethyl) lysine) and receptors for advanced glycation end products (AGEs), antagonized oxidative stress and nuclear factor-kappa B activation elicited by fructose feeding, suggesting inhibition of glycation, oxidative stress and nuclear factor-kappa B activation may be involved in the antifibrotic mechanisms. Betanin also showed anitglycative effect in BSA/fructose system, which supported that anitglycation was involved in betanin's protective roles in vivo. Taken together, the potential for using betanin as an auxiliary therapy for diabetic cardiomyopathy deserves to be explored further. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
C1 [Han, Junyan; Wang, Yiheng; Yang, Shaobin] Shenyang Univ, Coll Life Sci & Engn, Shenyang 110044, Peoples R China.
   [Tan, Chang] China Med Univ, Coll Basic Med Sci, Shenyang 110001, Peoples R China.
   [Tan, Dehong] Shenyang Agr Univ, Coll Food, Shenyang 110866, Peoples R China.
C3 Shenyang University; China Medical University; Shenyang Agricultural
   University
RP Han, JY (corresponding author), Shenyang Univ, Coll Life Sci & Engn, Shenyang 110044, Peoples R China.
EM hanjunyan@aliyun.com; tandehongsy@126.com
FU Major Science and Technology Platform Project of Liaoning Province
   Education Department
FX Financial support from the grants of Major Science and Technology
   Platform Project of Liaoning Province Education Department is gratefully
   acknowledged.
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NR 51
TC 56
Z9 57
U1 0
U2 25
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0009-2797
EI 1872-7786
J9 CHEM-BIOL INTERACT
JI Chem.-Biol. Interact.
PD FEB 5
PY 2015
VL 227
BP 37
EP 44
DI 10.1016/j.cbi.2014.12.032
PG 8
WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology
GA CC1GE
UT WOS:000350088400005
PM 25559852
DA 2025-06-11
ER

PT J
AU Arija, V
   Fernández-Cao, JC
   Basora, J
   Bulló, M
   Aranda, N
   Estruch, R
   Martínez-González, MA
   Salas-Salvadó, J
AF Arija, Victoria
   Fernandez-Cao, Jose C.
   Basora, Josep
   Bullo, Monica
   Aranda, Nuria
   Estruch, Ramon
   Martinez-Gonzalez, Miguel A.
   Salas-Salvado, Jordi
TI Excess body iron and the risk of type 2 diabetes mellitus: a nested
   case-control in the PREDIMED (PREvention with MEDiterranean Diet) study
SO BRITISH JOURNAL OF NUTRITION
LA English
DT Article
DE Serum ferritin; Soluble transferrin receptor; Body iron stores; Type 2
   diabetes
ID SERUM TRANSFERRIN RECEPTOR; HEMOCHROMATOSIS GENE; OXIDATIVE STRESS;
   FERRITIN; STORES; QUESTIONNAIRE; POPULATION; MUTATIONS; FREQUENCY;
   DIAGNOSIS
AB A prospective nested case-control study within the PREvention with MEDiterranean Diet (PREDIMED) was conducted to evaluate the relationship between excess body Fe (measured as serum ferritin (SF), soluble transferrin receptor (sTfR) and sTfR: ferritin ratio) and the risk of type 2 diabetes mellitus (T2DM) in a Mediterranean population at a high risk of CVD, without T2DM at the start of the study. The study contained 459 subjects, 153 with incident T2DM (cases) and 306 without incident T2DM (controls). The follow-up period was for 6.0 (interquartile range 3.9-6.5) years. For each incident diabetic subject, two subjects were selected as controls who were matched broadly for age as well as for sex, intervention group and BMI. We observed a relationship between SF values >257 mu g/l in males and >139 mu g/l in females and the risk of T2DM, following adjustment in the conditional logistic regression model for high-sensitivity C-reactive protein, fasting glucose and other components of the metabolic syndrome (OR 3.62, 95% CI 1.32, 19.95; P = 0.022). We also found an association between low sTfR: ferritin ratio levels and the incidence of T2DM (OR 3.02, 95% CI 1.09, 8.39; P = 0.042), but no association with sTfR (OR 1.29, 95% CI 0.51, 3.23; P = 0.722). Oxidative stress has been hypothesised to contribute to the development of insulin resistance and beta-cell dysfunction, the two key events in the clinical development of T2DM. Following adjustment for other risk factors for T2DM, excess body Fe (measured as SF and sTfR: ferritin ratio) was associated with an increased risk of developing T2DM in a Mediterranean population at a high risk of CVD.
C1 [Arija, Victoria; Fernandez-Cao, Jose C.; Aranda, Nuria] Univ Rovira & Virgili, Nutr & Publ Hlth Unit, Tarragona 43201, Spain.
   [Arija, Victoria; Basora, Josep] Inst Invest Atencio Primaria IDIAP, Reus Altebrat Primary Care, Reus, Spain.
   [Arija, Victoria; Basora, Josep; Bullo, Monica; Aranda, Nuria; Salas-Salvado, Jordi] Univ Rovira & Virgili, Pere Virgili Hlth Res Inst, Tarragona 43201, Spain.
   [Basora, Josep; Bullo, Monica; Salas-Salvado, Jordi] Univ Rovira & Virgili, Human Nutr Unit, Tarragona 43201, Spain.
   [Basora, Josep; Bullo, Monica; Estruch, Ramon; Martinez-Gonzalez, Miguel A.; Salas-Salvado, Jordi] Inst Salud Carlos III, CIBERobn Physiopathol Obes & Nutr, Madrid, Spain.
   [Estruch, Ramon] Univ Barcelona, Hosp Clin, IDIBAPS, Dept Internal Med, Barcelona, Spain.
   [Martinez-Gonzalez, Miguel A.] Univ Navarra, Dept Prevent Med & Publ Hlth, E-31080 Pamplona, Spain.
C3 Universitat Rovira i Virgili; Universitat Rovira i Virgili; Universitat
   Rovira i Virgili; Instituto de Salud Carlos III; CIBER - Centro de
   Investigacion Biomedica en Red; CIBEROBN; University of Barcelona;
   Hospital Clinic de Barcelona; IDIBAPS; University of Navarra
RP Arija, V (corresponding author), Univ Rovira & Virgili, Nutr & Publ Hlth Unit, C Sant Llorenc 21, Tarragona 43201, Spain.
EM victoria.arija@urv.cat; jordi.salas@urv.cat
RI Martinez-Gonzalez, Miguel/AAE-7669-2019; Estruch, Ramon/AAZ-3723-2020;
   Fernandez-Cao, Jose Candido/N-1509-2018; Aranda, Nuria/D-1942-2016;
   Salas-Salvado, Jordi/C-7229-2017; Bullo, Monica/F-2925-2016
OI Fernandez-Cao, Jose Candido/0000-0002-1697-3443; Aranda,
   Nuria/0000-0001-9708-747X; Arija, Victoria/0000-0002-1758-0975;
   Salas-Salvado, Jordi/0000-0003-2700-7459; Basora,
   Josep/0000-0003-0278-1149; Bullo, Monica/0000-0002-0218-7046
FU Spanish Ministry of Health (Instituto de Salud Carlos III) [PI1001407,
   PI1301090, FIS PI10/0082, G03/140, RD06/0045]; FEDER (Fondo Europeo de
   Desarrollo Regional); Public Health Division of the Department of Health
   of the Autonomous Government of Catalonia; Caixa Tarragona [10-1343]
FX The study was funded in part by the Spanish Ministry of Health
   (Instituto de Salud Carlos III; PI1001407, PI1301090, FIS PI10/0082,
   G03/140, RD06/0045), the FEDER (Fondo Europeo de Desarrollo Regional),
   the Public Health Division of the Department of Health of the Autonomous
   Government of Catalonia, and Caixa Tarragona (10-1343). The Fundacion
   Patrimonio Comunal Olivarero and Hojiblanca SA (Malaga, Spain),
   California Walnut Commission (Sacramento, CA), Borges SA (Reus, Spain)
   and Morella Nuts SA (Reus, Spain) donated the olive oil, walnuts,
   almonds and hazelnuts, respectively, used in the PREDIMED study. None of
   the funding sources played any role in the design, collection, analysis
   or interpretation of the data or in the decision to submit the
   manuscript for publication. CIBER de Obesidad y Nutricion is a national
   initiative of the Instituto de Salud Carlos III. No funding body had any
   role in the design, analysis or writing of this article.
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NR 40
TC 23
Z9 23
U1 0
U2 19
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1145
EI 1475-2662
J9 BRIT J NUTR
JI Br. J. Nutr.
PD DEC 14
PY 2014
VL 112
IS 11
BP 1896
EP 1904
DI 10.1017/S0007114514002852
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA AX7NH
UT WOS:000347102000015
PM 25322842
OA Bronze
DA 2025-06-11
ER

PT J
AU Zhang, HQ
   Chu, X
   Huang, YF
   Li, G
   Wang, YX
   Li, Y
   Sun, CH
AF Zhang, Huaqi
   Chu, Xia
   Huang, Yifan
   Li, Gang
   Wang, Yuxia
   Li, Ying
   Sun, Changhao
TI Maternal vitamin D deficiency during pregnancy results in insulin
   resistance in rat offspring, which is associated with inflammation and
   Iκbα methylation
SO DIABETOLOGIA
LA English
DT Article
DE DNA methylation; Inflammation; Insulin resistance; VitaminD deficiency
ID METABOLIC SYNDROME; OXIDATIVE STRESS; GENE; RECEPTOR; DISEASE;
   EPIGENETICS; SECRETION; RESPONSES; CHILDREN; HEALTHY
AB Aims/hypothesis We aimed to investigate the impact of maternal vitamin D deficiency during pregnancy on insulin resistance in male offspring and examine its mechanism.
   Methods Pregnant Sprague-Dawley rats were maintained on a vitamin-D-free diet with ultraviolet-free light during pregnancy (early-VDD group). Insulin resistance in the male offspring was assessed by HOMA-IR, OGTT and euglycaemic clamp. NEFA, oxidative stress and inflammation levels were estimated as risk factors for insulin resistance. DNA methylation was examined by bisulfate sequencing PCR analysis. Luciferase reporter assay was performed to validate the effect of DNA methylation.
   Results The offspring in the early-VDD group had significantly higher fasting insulin and HOMA-IR levels, markedly reduced glucose tolerance and significantly lower tissue sensitivity to exogenous insulin at 16 weeks (all p < 0.05) compared with control offspring. Significantly higher serum and liver IL-1 beta, IL-6, IL-8 and TNF-alpha concentrations were observed in the offspring of the early-VDD group at 0, 3, 8 and 16 weeks. Expression of hepatic I kappa b alpha (also known as Nfkbia) mRNA and nuclear factor kappa B inhibitor alpha (I kappa B alpha) protein was persistently lower in the early-VDD offspring at all time points, and their hepatic I kappa b alpha methylation levels at the cytosine phosphate guanine site +331 were significantly higher at 0 and 16 weeks (all p < 0.01). Methylation at I kappa b alpha first exon +331 markedly decreased the luciferase activity (p < 0.05).
   Conclusions/interpretation Maternal vitamin D deficiency during pregnancy results in insulin resistance in the offspring, which is associated with persistently increased inflammation. Persistently decreased I kappa b alpha expression, potentially caused by changes in I kappa b alpha methylation, plays an important role in persistent inflammation.
C1 [Zhang, Huaqi; Chu, Xia; Huang, Yifan; Li, Ying; Sun, Changhao] Harbin Med Univ, Coll Publ Hlth, Dept Nutr & Food Hyg, Harbin 150081, Peoples R China.
   [Li, Gang] Harbin Med Univ, Affiliated Hosp 2, Harbin, Peoples R China.
   [Wang, Yuxia] Harbin Med Univ, Affiliated Hosp 3, Harbin, Peoples R China.
C3 Harbin Medical University; Harbin Medical University; Harbin Medical
   University
RP Li, Y (corresponding author), Harbin Med Univ, Coll Publ Hlth, Dept Nutr & Food Hyg, 157 Baojian Rd, Harbin 150081, Peoples R China.
EM liying_helen@163.com; sun2002changhao@yahoo.com
RI Zhang, Zhihong/IAP-0255-2023
FU State Key Program of National Natural Science of China [81130049];
   National `Twelfth Five-Year' Plan for Science Technology [2012BAI02B02];
   Program for New Century Excellent Talents in University of Ministry of
   Education of China [NCET-10-0148]
FX This study was supported by the State Key Program of National Natural
   Science of China (No. 81130049), the National `Twelfth Five-Year' Plan
   for Science & Technology Support (No. 2012BAI02B02) and the Program for
   New Century Excellent Talents in University of Ministry of Education of
   China (grant NCET-10-0148).
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NR 34
TC 48
Z9 51
U1 0
U2 25
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0012-186X
EI 1432-0428
J9 DIABETOLOGIA
JI Diabetologia
PD OCT
PY 2014
VL 57
IS 10
BP 2165
EP 2172
DI 10.1007/s00125-014-3316-7
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA AO9VZ
UT WOS:000341708900019
PM 24985146
DA 2025-06-11
ER

PT J
AU Evans, CS
   Gooch, L
   Flotta, D
   Lykins, D
   Powers, RW
   Landsittel, D
   Roberts, JM
   Shroff, SG
AF Evans, Caroline S.
   Gooch, Linda
   Flotta, Deborah
   Lykins, David
   Powers, Robert W.
   Landsittel, Douglas
   Roberts, James M.
   Shroff, Sanjeev G.
TI Cardiovascular System During the Postpartum State in Women With a
   History of Preeclampsia
SO HYPERTENSION
LA English
DT Article
DE preeclampsia; cardiac function; blood pressure; plethysmography;
   vascular resistance; compliance; endothelial function
ID TOTAL ARTERIAL COMPLIANCE; ISCHEMIC-HEART-DISEASE; NORMAL-PREGNANCY;
   INSULIN-RESISTANCE; ENDOTHELIAL DYSFUNCTION; CHRONIC HYPERTENSION;
   METABOLIC SYNDROME; BLOOD-PRESSURE; LATER LIFE; RISK
AB In subjects with previous preeclampsia, differences in cardiovascular and/or blood biochemical parameters are present in the nonpregnant state, and a simultaneous assessment of multiple derived indices better differentiates between women with or without previous preeclampsia. We examined 18 previous preeclamptic and 50 previous uncomplicated pregnancies, approximate to 16 months postpartum. Cardiovascular assessment included the following: (1) systemic hemodynamics and mechanics (Doppler echocardiography, tonometry, and oscillometric sphygmomanometry); (2) endothelial function (plethysmography); (3) left ventricular properties (echocardiography); and (4) blood biochemical analyses. Compared to women with previous uncomplicated pregnancies, previous preeclamptics had higher mean (80 +/- 1 versus 86 +/- 3 mm Hg; P=0.04) and diastolic (64 +/- 1 versus 68 +/- 2 mm Hg; P=0.04) pressures and total vascular resistance (1562 +/- 37 versus 1784 +/- 114 dyne . s/cm(5); P=0.03). Systolic blood pressure, arterial compliance, and left ventricular properties were not different. Although heart-to-femoral pulse wave velocity was not different, heart-to-brachial pulse wave velocity tended to be faster in previous preeclamptics (374 +/- 8 versus 404 +/- 20 cm/s; P=0.06). Stress-induced increase in forearm blood flow was less in previous preeclamptics (245%+/- 21% versus 136%+/- 22%; P=0.01), indicating impaired endothelial function. No significant differences were observed in markers of endothelial activation, dyslipidemia, or oxidative stress; previous preeclamptics tended to have higher glucose level (58.7 +/- 1.9 versus 95 +/- 5.2 mg/dL; P=0.06). Logistic regression analysis indicated that a simultaneous evaluation of multiple derived indices better discriminated between the 2 groups. The differences in the previous preeclamptic group are in directions known to be associated with greater cardiovascular disease risk later in life. (Hypertension. 2011;58:57-62.). Online Data Supplement
C1 [Evans, Caroline S.; Shroff, Sanjeev G.] Univ Pittsburgh, Dept Bioengn, Pittsburgh, PA 15219 USA.
   [Powers, Robert W.; Roberts, James M.] Univ Pittsburgh, Dept Obstet & Gynecol & Reprod Sci, Pittsburgh, PA 15219 USA.
   [Landsittel, Douglas] Univ Pittsburgh, Div Gen Internal Med, Pittsburgh, PA 15219 USA.
   [Gooch, Linda; Flotta, Deborah; Lykins, David; Powers, Robert W.; Roberts, James M.] Univ Pittsburgh, Magee Womens Hosp, Pittsburgh, PA 15219 USA.
   [Shroff, Sanjeev G.] Univ Pittsburgh, McGowan Inst Regenerat Med, Pittsburgh, PA 15219 USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE); University
   of Pittsburgh; Pennsylvania Commonwealth System of Higher Education
   (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of
   Higher Education (PCSHE); University of Pittsburgh; Pennsylvania
   Commonwealth System of Higher Education (PCSHE); University of
   Pittsburgh; Pennsylvania Commonwealth System of Higher Education
   (PCSHE); University of Pittsburgh
RP Shroff, SG (corresponding author), Univ Pittsburgh, Dept Bioengn, 300 Technol Dr,306 Ctr Bioengn, Pittsburgh, PA 15219 USA.
EM sshroff@pitt.edu
RI Roberts, James/AAI-3283-2020
FU National Institutes of Health [P01 HD30367]; McGinnis Endowed Chair
   funds; National Center for Research Resources, a component of National
   Institutes of Health, and National Institutes of Health Roadmap for
   Medical Research [UL1 RR024153]
FX All of the studies were conducted at the Clinical Research Center,
   Magee-Womens Hospital. Primary support for this project was provided by
   P01 HD30367, a grant from the National Institutes of Health. Additional
   support was provided by the McGinnis Endowed Chair funds and grant UL1
   RR024153 from the National Center for Research Resources, a component of
   National Institutes of Health, and National Institutes of Health Roadmap
   for Medical Research.
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NR 48
TC 74
Z9 85
U1 0
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0194-911X
EI 1524-4563
J9 HYPERTENSION
JI Hypertension
PD JUL
PY 2011
VL 58
IS 1
BP 57
EP U103
DI 10.1161/HYPERTENSIONAHA.111.173278
PG 11
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 777WE
UT WOS:000291655000011
PM 21606389
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Fortuño, A
   Bidegain, J
   Baltanás, A
   Moreno, MU
   Montero, L
   Landecho, MF
   Beloqui, O
   Díez, J
   Zalba, G
AF Fortuno, Ana
   Bidegain, Julen
   Baltanas, Ana
   Moreno, Maria U.
   Montero, Laura
   Landecho, Manuel F.
   Beloqui, Oscar
   Diez, Javier
   Zalba, Guillermo
TI Is leptin involved in phagocytic NADPH oxidase overactivity in obesity?
   Potential clinical implications
SO JOURNAL OF HYPERTENSION
LA English
DT Article
DE leptin; NADPH oxidase; obesity; vascular remodeling
ID DEPENDENT SUPEROXIDE-PRODUCTION; INTIMA-MEDIA THICKNESS; OXIDATIVE
   STRESS; CARDIOVASCULAR-DISEASE; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   SMOOTH-MUSCLE; NOX FAMILY; EXPRESSION; GENERATION
AB Objectives Hyperleptinemia and oxidative stress play a major role in the development of cardiovascular diseases in obesity. This study aimed to investigate whether there is a relationship between plasma levels of leptin and phagocytic nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity, and its potential relevance in the vascular remodeling in obese patients.
   Methods The study was performed in 164 obese and 94 normal-weight individuals (controls). NADPH oxidase activity was evaluated by luminescence in phagocytic cells. Levels of leptin were quantified by ELISA in plasma samples. Carotid intima-media thickness (cIMT) was measured by ultrasonography. In addition, we performed in-vitro experiments in human peripheral blood mononuclear cells and murine macrophages.
   Results Phagocytic NADPH oxidase activity and leptin levels were enhanced (P<0.05) in obese patients compared with controls. NADPH oxidase activity positively correlated with leptin in obese patients. This association remained significant in a multivariate analysis. cIMT was higher (P<0.05) in obese patients compared with controls. In addition, cIMT also correlated positively with leptin and NADPH oxidase activity in obese patients. In-vitro studies showed that leptin induced NADPH oxidase activation. Inhibition of the leptin-induced NADPH oxidase activity by wortmannin and bisindolyl maleimide suggested a direct involvement of the phosphatidylinositol 3-kinase and protein kinase C pathways, respectively. Finally, leptin-induced NADPH oxidase activation promoted macrophage proliferation.
   Conclusions These findings show that phagocytic NADPH oxidase activity is increased in obesity and is related to preclinical atherosclerosis in this condition. We also suggest that hyperleptinemia may contribute to phagocytic NADPH oxidase overactivity in obesity. J Hypertens 28:1944-1950 (C) 2010 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
C1 [Fortuno, Ana; Bidegain, Julen; Baltanas, Ana; Moreno, Maria U.; Diez, Javier; Zalba, Guillermo] Univ Navarra, Ctr Appl Med Res, Div Cardiovasc Sci, Pamplona 31008, Spain.
   [Montero, Laura] Univ Navarra, Dept Clin Chem, Pamplona 31008, Spain.
   [Landecho, Manuel F.; Beloqui, Oscar] Univ Navarra, Dept Internal Med, Pamplona 31008, Spain.
   [Diez, Javier] Univ Navarra, Dept Cardiol & Cardiovasc Surg, Univ Clin, Pamplona 31008, Spain.
C3 University of Navarra; University of Navarra; University of Navarra;
   University of Navarra
RP Fortuño, A (corresponding author), Univ Navarra, Ctr Appl Med Res, Div Cardiovasc Sci, Pio 12 55, Pamplona 31008, Spain.
EM afortuno@unav.es; gzalba@unav.es
RI ZALBA, GUILLERMO/AAB-6231-2019; Landecho, Manuel/D-9227-2013; Fortuno,
   Ana/C-6921-2017; Moreno, MU/F-3278-2010; Diez Martinez, Domingo
   Francisco Javier/D-7014-2017
OI Fortuno, Ana/0000-0002-0796-4879; Moreno, MU/0000-0001-5441-9462;
   Beloqui Ruiz, Oscar/0000-0001-9542-3687; ZALBA,
   GUILLERMO/0000-0003-4616-1523; Diez Martinez, Domingo Francisco
   Javier/0000-0002-3414-6919; Landecho, Manuel F/0000-0003-3234-8805
FU Foundation for Applied Medical Research (FIMA); UTE; Instituto de Salud
   Carlos III, Ministry of Health, Spain [RD06/0014/0008]; European Union
   [LSHM-CT-2006-037093]; Ministry of Science [SAF2007-62553]
FX The work was funded through the agreement between the Foundation for
   Applied Medical Research (FIMA) and UTE project CIMA, the Red Tematica
   de Investigacion Cooperativa en Enfermedades Cardiovasculares (RECAVA)
   from the Instituto de Salud Carlos III, Ministry of Health, Spain (grant
   RD06/0014/0008), the European Union (InGenious HyperCare, grant
   LSHM-CT-2006-037093), and the SAF2007-62553 from Ministry of Science.
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NR 32
TC 44
Z9 47
U1 0
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0263-6352
EI 1473-5598
J9 J HYPERTENS
JI J. Hypertens.
PD SEP
PY 2010
VL 28
IS 9
BP 1944
EP 1950
DI 10.1097/HJH.0b013e32833c21af
PG 7
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 647GE
UT WOS:000281605300023
PM 20577124
DA 2025-06-11
ER

PT J
AU Yamaguchi, K
   Itoh, Y
   Yokomizo, C
   Nishimura, T
   Niimi, T
   Fujii, H
   Okanoue, T
   Yoshikawa, T
AF Yamaguchi, Kanji
   Itoh, Yoshito
   Yokomizo, Chihiro
   Nishimura, Takeshi
   Niimi, Toshihisa
   Fujii, Hideki
   Okanoue, Takeshi
   Yoshikawa, Toshikazu
TI Blockade of interleukin-6 signaling enhances hepatic steatosis but
   improves liver injury in methionine choline-deficient diet-fed mice
SO LABORATORY INVESTIGATION
LA English
DT Article
DE NASH; IL-6; MCD diet; STAT3; SREBP-1
ID ACTIVATED PROTEIN-KINASE; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   ADIPOSE-TISSUE; STEATOHEPATITIS; REGENERATION; INFLAMMATION; TRANSDUCER;
   LEVEL
AB Inflammatory processes have an important role in the development of hepatic steatosis and progression to nonalcoholic steatohepatitis (NASH). Interleukin-6 (IL-6) is known to be a proinflammatory cytokine, but also promotes liver regeneration and protects the liver against various forms of damage. The role of IL-6/Glycoprotein130 (GP130) in NASH remains unclear. In this study, we determined whether blocking IL-6/GP130 signaling prevents progression of steatohepatitis in a mouse NASH model. Six-week-old male C57/BL6 mice were fed either chow control or a methionine choline-deficient (MCD) diet for 8 weeks. Half of the MCD diet-fed mice were treated with 15 mg/kg rat anti-mouse IL-6 receptor antibody (MR16-1), intraperitoneally twice weekly, the remainder and chow-fed mice were injected with 15 mg/kg rat IgG as a control. Hepatic steatosis, injury, fibrosis, apoptosis, markers of lipid peroxidation/oxidant stress and IL-6-related gene expressions were evaluated. MR16-1 treatment decreased signal transducer and activator of transcription 3 activities and expression of suppressor of cytokine signaling 3 in MCD diet-treated mouse livers. Although this treatment enhanced intrahepatic lipid accumulation accompanied by increased sterol regulatory element-binding protein 1 and decreased peroxisome proliferator-activated receptor-a expression, elevated plasma alanine aminotransferase levels were improved with decreased plasma free fatty acid levels, lipid peroxidation/oxidant stress and hepatic apoptosis. Blocking IL-6/GP130 signaling by MR16-1 enhanced MCD diet-induced hepatic steatosis, but ameliorated liver injury. These findings suggest that hepatic IL-6 signaling has a protective role against the progression of hepatic steatosis but may enhance liver inflammation. Laboratory Investigation (2010) 90, 1169-1178; doi:10.1038/labinvest.2010.75; published online 5 April 2010
C1 [Itoh, Yoshito] Kyoto Prefectural Univ Med, Dept Mol Gastroenterol, Grad Sch Med Sci, Kamigyou Ku, Kyoto 6028566, Japan.
   [Okanoue, Takeshi] Saiseikai Suita Hosp, Ctr Gastroenterol & Hepatol, Osaka, Japan.
C3 Kyoto Prefectural University of Medicine
RP Itoh, Y (corresponding author), Kyoto Prefectural Univ Med, Dept Mol Gastroenterol, Grad Sch Med Sci, Kamigyou Ku, 465 Kajii Cho, Kyoto 6028566, Japan.
EM yitoh@koto.kpu-m.ac.jp
FU Japan Society for the Program of Science
FX This study was supported by a Grant-in-Aid for Scientific Research from
   the Japan Society for the Program of Science (Kanji Yamaguchi).
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NR 41
TC 101
Z9 111
U1 0
U2 13
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 0023-6837
EI 1530-0307
J9 LAB INVEST
JI Lab. Invest.
PD AUG
PY 2010
VL 90
IS 8
BP 1169
EP 1178
DI 10.1038/labinvest.2010.75
PG 10
WC Medicine, Research & Experimental; Pathology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pathology
GA 634AL
UT WOS:000280549600004
PM 20368703
OA Bronze
DA 2025-06-11
ER

PT J
AU Massip, L
   Garand, C
   Paquet, ER
   Cogger, VC
   O'Reilly, JN
   Tworek, L
   Hatherell, A
   Taylor, CG
   Thorin, E
   Zahradka, P
   Le Couteur, DG
   Lebel, M
AF Massip, Laurent
   Garand, Chantal
   Paquet, Eric R.
   Cogger, Victoria C.
   O'Reilly, Jennifer N.
   Tworek, Leslee
   Hatherell, Avril
   Taylor, Carla G.
   Thorin, Eric
   Zahradka, Peter
   Le Couteur, David G.
   Lebel, Michel
TI Vitamin C restores healthy aging in a mouse model for Werner syndrome
SO FASEB JOURNAL
LA English
DT Article
DE ascorbate; metabolism; microarrays; liver; adipocyte; inflammation
ID GENE-EXPRESSION PROFILES; L-ASCORBIC-ACID; INSULIN-RESISTANCE; SYNDROME
   PROTEIN; OXIDATIVE STRESS; POLY(ADP-RIBOSE) POLYMERASE-1; DWARF MICE;
   LIFE-SPAN; KAPPA-B; CELLS
AB Werner syndrome (WS) is a premature aging disorder caused by mutations in a RecQ-like DNA helicase. Mice lacking the helicase domain of the WRN homologue exhibit many phenotypic features of WS, including a prooxidant status and a shorter mean life span compared to wild-type animals. Here, we show that Wrn mutant mice also develop premature liver sinusoidal endothelial defenestration along with inflammation and metabolic syndrome. Vitamin C supplementation rescued the shorter mean life span of Wrn mutant mice and reversed several age-related abnormalities in adipose tissues and liver endothelial defenestration, genomic integrity, and inflammatory status. At the molecular level, phosphorylation of age-related stress markers like Akt kinase-specific substrates and the transcription factor NF-kappa B, as well as protein kinase C delta and Hif-1 alpha transcription factor levels, which are increased in the liver of Wrn mutants, were normalized by vitamin C. Vitamin C also increased the transcriptional regulator of lipid metabolism PPAR alpha. Finally, microarray and gene set enrichment analyses on liver tissues revealed that vitamin C decreased genes normally up-regulated in human WS fibroblasts and cancers, and it increased genes involved in tissue injury response and adipocyte dedifferentiation in obese mice. Vitamin C did not have such effect on wild-type mice. These results indicate that vitamin C supplementation could be beneficial for patients with WS.-Massip, L., Garand, C., Paquet, E. R., Cogger, V. C., O'Reilly, J. N., Tworek, L., Hatherell, A., Taylor, C. G., Thorin, E., Zahradka, P., Le Couteur, D. G., Lebel, M. Vitamin C restores healthy aging in a mouse model for Werner syndrome. FASEB J. 24, 158-172 ( 2010). www.fasebj.org
C1 [Massip, Laurent; Garand, Chantal; Paquet, Eric R.; Lebel, Michel] Univ Laval, Ctr Rech Cancerol, Hop Hotel Dieu, Quebec City, PQ, Canada.
   [Cogger, Victoria C.; O'Reilly, Jennifer N.; Le Couteur, David G.] Univ Sydney, Ctr Educ & Res Ageing, Sydney, NSW 2006, Australia.
   [Cogger, Victoria C.; O'Reilly, Jennifer N.; Le Couteur, David G.] Univ Sydney, ANZAC Res Inst, Sydney, NSW 2006, Australia.
   [Cogger, Victoria C.; O'Reilly, Jennifer N.; Le Couteur, David G.] Concord RG Hosp, Sydney, NSW, Australia.
   [Tworek, Leslee; Hatherell, Avril; Taylor, Carla G.; Zahradka, Peter] Univ Manitoba, Canadian Ctr Agri Food Res Hlth & Med, Winnipeg, MB, Canada.
   [Tworek, Leslee; Hatherell, Avril; Taylor, Carla G.; Zahradka, Peter] St Boniface Gen Hosp, Res Ctr, Winnipeg, MB, Canada.
   [Thorin, Eric] Univ Montreal, Montreal Heart Inst, Montreal, PQ, Canada.
C3 Laval University; University of Sydney; University of Sydney; ANZAC
   Research Institute; Concord Repatriation General Hospital; University of
   Manitoba; University of Manitoba; Saint Boniface Hospital; Children's
   Hospital Research Institute of Manitoba; Universite de Montreal
RP Lebel, M (corresponding author), Hop HoDieu Quebec, Ctr Rech Cancerol, 9 McMahon St, Quebec City, PQ G1R 2J6, Canada.
EM michel.lebel@crhdq.ulaval.ca
RI Zahradka, Peter/KDM-4700-2024; Thorin, Eric/K-3978-2013
OI Paquet, Eric/0000-0001-9194-1655; Taylor, Carla G./0000-0003-3358-6418;
   Thorin, Eric/0000-0001-5827-8935; Zahradka, Peter/0000-0002-7814-0658;
   Le Couteur, David/0000-0002-4227-5817; Garand,
   Chantal/0000-0003-0716-6487
FU Canadian Institutes of Health Research; National Sciences and
   Engineering Research Council of Canada; The National Health and Medical
   Research Council of Australia; Aging and Alzheimers Research Foundation
FX We thank Dr. O. Neyret-Djossou of the functional genomic platform of the
   Institut de Recherche Clinique de Montreal (Montreal, QC, Canada) for
   the microarray services. We are also grateful to M. Sild and A. Labbe
   for real-time RT-PCRs ( Centre de Recherche en Cancerologie de
   l'Universite Laval). This work was supported in part by grants from the
   Canadian Institutes of Health Research and from the National Sciences
   and Engineering Research Council of Canada to M. L. and from The
   National Health and Medical Research Council of Australia and from the
   Aging and Alzheimers Research Foundation ( a Division of the Medical
   Foundation of the University of Sydney) to D. G. L. M. L. is a senior
   scholar of the Fonds de la Recherche en Sante du Quebec.
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NR 69
TC 84
Z9 84
U1 0
U2 17
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
EI 1530-6860
J9 FASEB J
JI Faseb J.
PD JAN
PY 2010
VL 24
IS 1
BP 158
EP 172
DI 10.1096/fj.09-137133
PG 15
WC Biochemistry & Molecular Biology; Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 539DL
UT WOS:000273233600018
PM 19741171
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Klátyik, S
   Simon, G
   Takács, E
   Oláh, M
   Zaller, JG
   Antoniou, MN
   Benbrook, C
   Mesnage, R
   Székács, A
AF Klatyik, Szandra
   Simon, Gergely
   Takacs, Eszter
   Olah, Marianna
   Zaller, Johann G.
   Antoniou, Michael N.
   Benbrook, Charles
   Mesnage, Robin
   Szekacs, Andras
TI Toxicological concerns regarding glyphosate, its formulations, and
   co-formulants as environmental pollutants: a review of published studies
   from 2010 to 2025
SO ARCHIVES OF TOXICOLOGY
LA English
DT Review; Early Access
DE Glyphosate; Co-formulants; POEA; Microbiome; Oxidative stress;
   Genotoxicity
ID AMINOMETHYLPHOSPHONIC ACID AMPA; OXIDATIVE STRESS; DNA-DAMAGE; IN-VITRO;
   COMMERCIAL FORMULATION; HERBICIDE ROUNDUP; NEONATAL EXPOSURE; SURFACE
   WATERS; SPERM QUALITY; PLANT
AB Over the last decade and worldwide, an enormous investment in research and data collection has been made in the hope of better understanding the possible ecological and toxicological impacts triggered by glyphosate (GLY). This broad-spectrum, systemic herbicide became the most heavily applied pesticide ever in the 2000s. It is sprayed in many different ways in both agricultural and non-agricultural settings, resulting in multiple routes of exposure to organisms up and down the tree of life. Yet, relatively little is known about the environmental fate of GLY-based herbicide (GBH) formulations, and even less on how GBH co-formulants alter the absorption, distribution, metabolism, excretion, and toxicity of GLY. The environmental fate of GLY depends on several abiotic and biotic factors. As a result of heavy annual GBH use over several decades, GLY residues are ubiquitous, and sometimes adversely affect non-target terrestrial and aquatic organisms. GLY has become a frequent contaminant in drinking water and food chains. Human exposures have been associated with numerous adverse health outcomes including carcinogenicity, metabolic syndrome, and reproductive and endocrine-system effects. Nonetheless, the existence and magnitude of GLY-induced effects on human health remain in dispute, especially in the case of heavily exposed applicators. A wide range of biochemical/physiological modes of action have been elucidated. Various GBH co-formulants have long been considered as inert ingredients relative to herbicidal activity but clearly contribute to GLY-induced hazards and risk gradients. In light of already-identified toxicological and ecosystem impacts, the intensive research focuses on GLY and GBHs should continue, coupled in the interim with commonsense, low-cost changes in use patterns and label requirements crafted to slow the spread of GLY-resistant weeds and reduce applicator and general-population exposures.
C1 [Klatyik, Szandra; Takacs, Eszter; Olah, Marianna; Szekacs, Andras] Hungarian Univ Agr & Life Sci, Inst Environm Sci, Agroenvironm Res Ctr, Pater K U 1, H-2100 Godollo, Hungary.
   [Simon, Gergely] Pesticide Act Network Europe, Rue Pacificat 67, B-1000 Brussels, Belgium.
   [Zaller, Johann G.] Univ Nat Resources & Life Sci Vienna, Inst Zool, Dept Integrat Biol & Biodivers Res, Gregor Mendel Str 33, A-1180 Vienna, Austria.
   [Antoniou, Michael N.; Mesnage, Robin] Kings Coll London, Guys Hosp, Fac Life Sci & Med, Dept Med & Mol Genet,Gene Express & Therapy Grp, London SE1 9RT, England.
   [Mesnage, Robin] Buchinger Wilhelmi Clin, Wilhelmi Beck Str 27, D-88662 Uberlingen, Germany.
   [Benbrook, Charles] Benbrook Consulting Serv, 10526 SE Vashon Vista Dr, Port Orchard, WA 98367 USA.
C3 Hungarian University of Agriculture & Life Sciences; BOKU University;
   Guy's & St Thomas' NHS Foundation Trust; University of London; King's
   College London
RP Székács, A (corresponding author), Hungarian Univ Agr & Life Sci, Inst Environm Sci, Agroenvironm Res Ctr, Pater K U 1, H-2100 Godollo, Hungary.; Mesnage, R (corresponding author), Kings Coll London, Guys Hosp, Fac Life Sci & Med, Dept Med & Mol Genet,Gene Express & Therapy Grp, London SE1 9RT, England.; Mesnage, R (corresponding author), Buchinger Wilhelmi Clin, Wilhelmi Beck Str 27, D-88662 Uberlingen, Germany.
EM robin.mesnage@kcl.ac.uk; szekacs.andras@uni-mate.hu
RI Mesnage, Robin/AAD-8641-2019; Klátyik, Szandra/JFJ-3810-2023; Zaller,
   Johann/A-9914-2009
FU Hungarian University of Agriculture and Life Sciences; Centre for
   Circular Economy Analysis; Hungarian University of Agricultural and Life
   Sciences (MATE)
FX The authors thank the Centre for Circular Economy Analysis founded by
   the Hungarian University of Agricultural and Life Sciences (MATE) for
   enrolling this international collaboration in its education profile.
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NR 329
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0340-5761
EI 1432-0738
J9 ARCH TOXICOL
JI Arch. Toxicol.
PD 2025 MAY 26
PY 2025
DI 10.1007/s00204-025-04076-2
EA MAY 2025
PG 35
WC Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Toxicology
GA 2ZF9R
UT WOS:001494844700001
PM 40418353
DA 2025-06-11
ER

PT J
AU Salon, A
   Schmid-Zalaudek, K
   Steuber, B
   Rudlof, ME
   Bartel, TO
   Mächler, P
   Dorr, A
   Picha, R
   Fredriksen, PM
   Nkeh-Chungag, BN
   Goswami, N
AF Salon, Adam
   Schmid-Zalaudek, Karin
   Steuber, Bianca
   Rudlof, Maximilian Elliot
   Bartel, Till Olaf
   Maechler, Petra
   Dorr, Andreas
   Picha, Rainer
   Fredriksen, Per Morten
   Nkeh-Chungag, Benedicta Ngwenchi
   Goswami, Nandu
TI Randomized Trial: A Pilot Study Investigating the Effects of
   Transcendental Meditation and Yoga Through Retinal Microcirculation in
   Cardiac Rehabilitation
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Article
DE cardiac rehabilitation; exercise therapy; meditation; yoga; retinal
   imaging
ID CORONARY-HEART-DISEASE; BLOOD-PRESSURE RESPONSE; CARDIOVASCULAR-DISEASE;
   STRESS REDUCTION; RISK-FACTORS; METABOLIC SYNDROME; EXERCISE;
   HYPERTENSION; METAANALYSIS; MORTALITY
AB Background/Objectives: Cardiovascular diseases are a leading cause of death, and psychosocial stress is considered a contributing factor to these issues. With the rising number of heart surgeries, proper rehabilitation post-surgery is essential. Previous studies have demonstrated the positive impact of yoga and transcendental meditation on the cardiovascular system. This pilot study aimed to investigate the effects of yoga and transcendental meditation on retinal microcirculation in cardiac patients before (admission), after (discharge), and following (3 weeks after discharge) rehabilitation. Methods: This study examined changes in retinal microcirculation in three rehabilitation groups of patients after heart surgery. The control group received standard exercise therapy, while the meditation group incorporated 20 min of meditation, and the yoga group incorporated 20 min of yoga practice, twice per day for the duration of four weeks of rehabilitation. Retinal images were captured using a non-mydriatic digital retinal camera (Canon CR-2, Canon Medical Systems Europe B.V., Netherlands), and the microcirculation parameters central retinal artery equivalent, central retinal vein equivalent, and artery-to-vein ratio were analyzed using MONA REVA software ((version 2.1.1), VITO, Mol, Belgium). Repeated measures ANOVA was performed to evaluate differences between the three groups in the course of rehabilitation. Results: None of the parameters revealed significant differences in retinal microcirculation between the three rehabilitation groups. Conclusions: The study evaluating changes in retinal microcirculation, as an indicator of central circulation in cardiac patients undergoing rehabilitation, did not observe any significant changes. As yoga and meditation are underestimated approaches in cardiac rehabilitation, this pilot study acts as a basis for providing preliminary information for future studies to encourage the research community to fill the gap in this area.
C1 [Salon, Adam; Schmid-Zalaudek, Karin; Steuber, Bianca; Rudlof, Maximilian Elliot; Bartel, Till Olaf; Goswami, Nandu] Med Univ Graz, Div Physiol & Pathophysiol, Grav Physiol & Med Res Unit, A-8010 Graz, Austria.
   [Salon, Adam; Fredriksen, Per Morten] Inland Norway Univ Appl Sci, Fac Appl Ecol Agr Sci & Biotechnol, N-2624 Lillehammer, Norway.
   [Salon, Adam] Augusta Univ, Vasc Biol Ctr, Augusta, GA 30912 USA.
   [Maechler, Petra; Dorr, Andreas; Picha, Rainer] Rehabil Ctr Cardiovasc Dis, A-8061 St Radegund, Austria.
   [Nkeh-Chungag, Benedicta Ngwenchi] Walter Sisulu Univ, Fac Hlth Sci, Dept Biol & Environm Sci, PBX1, ZA-5117 Mthatha, South Africa.
   [Goswami, Nandu] Mohammed Bin Rashid Univ Med & Hlth Sci, Ctr Space & Aviat Hlth, Coll Med, Dubai 505055, U Arab Emirates.
C3 Medical University of Graz; Inland Norway University of Applied
   Sciences; University System of Georgia; Augusta University; Walter
   Sisulu University
RP Salon, A; Goswami, N (corresponding author), Med Univ Graz, Div Physiol & Pathophysiol, Grav Physiol & Med Res Unit, A-8010 Graz, Austria.; Salon, A (corresponding author), Inland Norway Univ Appl Sci, Fac Appl Ecol Agr Sci & Biotechnol, N-2624 Lillehammer, Norway.; Salon, A (corresponding author), Augusta Univ, Vasc Biol Ctr, Augusta, GA 30912 USA.; Goswami, N (corresponding author), Mohammed Bin Rashid Univ Med & Hlth Sci, Ctr Space & Aviat Hlth, Coll Med, Dubai 505055, U Arab Emirates.
EM adam.salon.pro@gmail.com; nandu.goswami@medunigraz.at
RI Saloň, Adam/JYO-7882-2024; Goswami, Nandu/B-4021-2011; Chungag,
   Benedicta/AAU-8632-2021; Schmid-Zalaudek, Karin/AAJ-2417-2021
OI Schmid-Zalaudek, Karin/0000-0002-3422-0031; Salon,
   Adam/0009-0003-1496-8813; Nkeh-Chungag, Benedicta
   Ngwenchi/0000-0003-4805-4051; Brix, Bianca/0000-0002-7308-5450; Goswami,
   Nandu/0000-0002-6704-0723
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NR 68
TC 1
Z9 1
U1 2
U2 2
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD JAN
PY 2025
VL 14
IS 1
AR 232
DI 10.3390/jcm14010232
PG 18
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA R8F7T
UT WOS:001393745700001
PM 39797312
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU El-bakry, KAM
   Bahnasawy, MH
   Deef, LE
   Ahmed-Farid, OAH
   El-Naeli, SSB
AF El-bakry, Kadry Abd-El kader Moktar
   Bahnasawy, Mohammad Hamid
   Deef, Lamiaa Elsayed
   Ahmed-Farid, Omar Abdel-Hamed
   El-Naeli, Samia Salem Basheer
TI Tolerability of Artemisia absinthium in anorexia: Targeting of neuronal
   appetite and satiety in zinc deficiency diet rat model
SO SCIENTIFIC AFRICAN
LA English
DT Article
DE Neurotransmitter modulation; Feeding regulation; Herbal treatment and
   appetite modulation
ID OXIDATIVE STRESS; NEUROPEPTIDE-Y; FOOD-INTAKE; BRAIN; L.; METABOLISM;
   TOXICITY; GHRELIN
AB Anorexia is a neuronal metabolic disorders induced by factors such as malnutrition and brain metabolic abnormalities during crucial developmental stages. Anorexia nervosa is a complex condition that often requires a multidisciplinary approach, involving medical, nutritional, and psychological interventions. The available medications for specific symptoms for increasing feed intake, not applicable for children and pregnant and cancer patients such as Olanzapine, and Cyproheptadine. This study looked at how Artemisia absinthium (ART) affects brain metabolic syndrome brought on zinc deficiency diet (ZDD). The investigation examined the impact of a ZDD on a rat anorexia model. The second goal is to contrast how antihistamines and Artemisia absinthe extract affect the brain functions connected to appetite. For the studies, 40 mature male rats were divided into four groups. Four groups of forty rats each were used in the experiment. Each group consists of ten rats. The following groups are included in the study: the 1st group control group, the 2nd group treated with ZDD, the 3rd group treated with ZDD concurrent with Cyproheptadine (CH), the 4th group treated with ZDD concurrent with ART. CH and ART were taken orally for 30 days. Tests on biochemical markers were conducted after the examination. The findings showed that ZDD led to reduced levels of neurotransmitters in the brain. Lower concentrations of antioxidants, monoamine, and neuropeptide Y were also found. On the other hand, groups treated with CH and ART improved in comparison to ZDD and nearly recovered in comparison to the control group. Histopathological analysis was used to confirm biochemical data. Obtained data concluded that CH and ART reduce the effects of anorexia and oxidative stress, which function as neuromodulators and promote the release of monoamines.
C1 [El-bakry, Kadry Abd-El kader Moktar; Bahnasawy, Mohammad Hamid; Deef, Lamiaa Elsayed] Damietta Univ, Fac Sci, Zool Dept, Dumyat, Egypt.
   [Ahmed-Farid, Omar Abdel-Hamed] NODCAR, Physiol Dept, Giza, Egypt.
   [El-Naeli, Samia Salem Basheer] Al Zawia Univ, Fac Sci, Zool Dept, Al Zawia, Libya.
C3 Egyptian Knowledge Bank (EKB); Damietta University; National
   Organization for Drug Control & Research (NODCAR)
RP Ahmed-Farid, OAH (corresponding author), NODCAR, Physiol Dept, Giza, Egypt.
EM ebntaimya@yahoo.com
RI Ahmed-Farid, Omar/AAE-8278-2022
OI Ahmed-Farid, Omar/0000-0002-1020-5777
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NR 65
TC 1
Z9 1
U1 1
U2 2
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2468-2276
J9 SCI AFR
JI Sci. Afr.
PD JUN
PY 2024
VL 24
AR e02162
DI 10.1016/j.sciaf.2024.e02162
EA MAR 2024
PG 9
WC Multidisciplinary Sciences
WE Emerging Sources Citation Index (ESCI)
SC Science & Technology - Other Topics
GA OM2F2
UT WOS:001207617400001
OA gold
DA 2025-06-11
ER

PT J
AU Gonzalez, MB
   Robker, RL
   Rose, RD
AF Gonzalez, Macarena B.
   Robker, Rebecca L.
   Rose, Ryan D.
TI Obesity and oocyte quality: significant implications for ART and
   emerging mechanistic insights
SO BIOLOGY OF REPRODUCTION
LA English
DT Article
DE obesity; women's health; oocyte; oocyte quality; ART; IVF; ICSI;
   reproductive success
ID BODY-MASS INDEX; IN-VITRO FERTILIZATION; ASSISTED REPRODUCTIVE
   TECHNOLOGY; ENDOPLASMIC-RETICULUM STRESS; POLYCYSTIC-OVARY-SYNDROME;
   DIET-INDUCED OBESITY; INTRACYTOPLASMIC SPERM INJECTION; FOLLICULAR-FLUID
   LEPTIN; LIVE BIRTH-RATE; HIGH-FAT DIET
AB The prevalence of obesity in adults worldwide, and specifically in women of reproductive age, is concerning given the risks to fertility posed by the increased risk of type 2 diabetes, metabolic syndrome, and other noncommunicable diseases. Obesity has a multi-systemic impact in female physiology that is characterized by the presence of oxidative stress, lipotoxicity, and the activation of pro-inflammatory pathways, inducing tissue-specific insulin resistance and ultimately conducive to abnormal ovarian function. A higher body mass is linked to Polycystic Ovary Syndrome, dysregulated menstrual cycles, anovulation, and longer time to pregnancy, even in ovulatory women. In the context of assisted reproductive technology (ART), compared to women of normal body mass index, obese women have worse outcomes in every step of their journey, resulting in reduced success measured as live birth rate. Even after pregnancy is achieved, obese women have a higher chance of miscarriage, gestational diabetes, pregnancy complications, birth defects, and most worryingly, a higher risk of stillbirth and neonatal death. The potential for compounding effects of ART on pregnancy complications and infant morbidities in obese women has not been studied. There is still much debate in the field on whether these poorer outcomes are mainly driven by defects in oocyte quality, abnormal embryo development, or an unaccommodating uterine environment, however the clinical evidence to date suggests a combination of all three are responsible. Animal models of maternal obesity shed light on the mechanisms underlying the effects of obesity on the peri-conception environment, with recent findings pointing to lipotoxicity in the ovarian environment as a key driver of defects in oocytes that have not only reduced developmental competence but long-lasting effects in offspring health.
C1 [Gonzalez, Macarena B.; Robker, Rebecca L.; Rose, Ryan D.] Univ Adelaide, Sch Biomed, Robinson Res Inst, Adelaide, SA, Australia.
   [Rose, Ryan D.] St Andrews Hosp, Fertil SA, Adelaide, SA, Australia.
C3 University of Adelaide; Robinson Research Institute; St Andrews Hospital
RP Gonzalez, MB (corresponding author), Univ Adelaide, Sch Biomed, Level 5, Adelaide, SA 5005, Australia.
EM macarena.bermudezgonzalez@adelaide.edu.au
RI Gonzalez, Macarena/AAA-2654-2022
OI Rose, Ryan/0000-0001-9732-1713; Gonzalez, Macarena/0000-0002-6567-938X
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NR 182
TC 32
Z9 34
U1 1
U2 12
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0006-3363
EI 1529-7268
J9 BIOL REPROD
JI Biol. Reprod.
PD FEB 22
PY 2022
VL 106
IS 2
BP 338
EP 350
DI 10.1093/biolre/ioab228
EA JAN 2022
PG 13
WC Reproductive Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Reproductive Biology
GA ZE7TP
UT WOS:000756753000001
PM 34918035
DA 2025-06-11
ER

PT J
AU Goh, GH
   Blache, D
   Mark, PJ
   Kennington, WJ
   Maloney, SK
AF Goh, Grace H.
   Blache, Dominique
   Mark, Peter J.
   Kennington, W. Jason
   Maloney, Shane K.
TI Daily temperature cycles prolong lifespan and have sex-specific effects
   on peripheral clock gene expression in Drosophila melanogaster
SO JOURNAL OF EXPERIMENTAL BIOLOGY
LA English
DT Article
DE Amplitude; Circadian rhythms; Clock genes; Drosophila melanogaster;
   Longevity; Temperature
ID SENESCENCE MARKER PROTEIN-30; MOLECULAR CIRCADIAN-RHYTHMS; DIETARY
   RESTRICTION; OXIDATIVE STRESS; BODY-TEMPERATURE; CAENORHABDITIS-ELEGANS;
   AMBIENT-TEMPERATURE; METABOLIC SYNDROME; SMP30 DEFICIENCY; LONGEVITY
AB Circadian rhythms optimize health by coordinating the timing of physiological processes to match predictable daily environmental challenges. The circadian rhythm of body temperature is thought to be an important modulator of molecular clocks in peripheral tissues, but how daily temperature cycles affect physiological function is unclear. Here, we examined the effect of constant temperature (T-con, 25 degrees C) and cycling temperature (T-cyc, 28 degrees C:22 degrees C during light:dark) paradigms on lifespan of Drosophila melanogaster, and the expression of clock genes, heat shock protein 83 (Hsp83), Frost (Fst) and senescence marker protein-30 (smp-30). Male and female D. melanogaster housed at T-cyc had longer median lifespans than those housed at T-con. T-cyc induced robust Hsp83 rhythms and rescued the age-related decrease in smp-30 expression that was observed in flies at T-con, potentially indicating an increased capacity to cope with age-related cellular stress. Ageing under T-con led to a decrease in the amplitude of expression of all clock genes in the bodies of male flies, except for cyc, which was non-rhythmic, and for per and cry in female flies. Strikingly, housing under T-cyc conditions rescued the age-related decrease in amplitude of all clock genes, and generated rhythmicity in cyc expression, in the male flies, but not the female flies. The results suggest that ambient temperature rhythms modulate D. melanogaster lifespan, and that the amplitude of clock gene expression in peripheral body clocks may be a potential link between temperature rhythms and longevity in male D. melanogaster. Longevity due to T-cyc appeared predominantly independent of clock gene amplitude in female D. melanogaster.
C1 [Goh, Grace H.; Mark, Peter J.; Maloney, Shane K.] Univ Western Australia, Sch Human Sci, Crawley, WA 6009, Australia.
   [Blache, Dominique] Univ Western Australia, Sch Agr & Environm, Crawley, WA 6009, Australia.
   [Kennington, W. Jason] Univ Western Australia, Sch Biol Sci, Crawley, WA 6009, Australia.
C3 University of Western Australia; University of Western Australia;
   University of Western Australia
RP Goh, GH (corresponding author), Univ Western Australia, Sch Human Sci, Crawley, WA 6009, Australia.
EM grace.goh@research.uwa.edu.au
RI maloney, shane/AAU-5811-2021; Goh, Grace/JDM-6402-2023; Mark,
   Peter/H-5365-2014; Kennington, Jason/H-5182-2014; Blache,
   Dominique/H-4991-2014
OI Maloney, Shane K/0000-0002-5878-2266; Mark, Peter/0000-0002-9380-2277;
   Kennington, Jason/0000-0001-6100-6543; Blache,
   Dominique/0000-0003-3476-3068; Goh, Grace/0000-0001-5431-9939
FU Forrest Research Foundation
FX G.H.G. was in receipt of a Forrest Research Foundation Scholarship, and
   all the authors are grateful for the support received from the Forrest
   Research Foundation.
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NR 92
TC 6
Z9 7
U1 1
U2 17
PU COMPANY BIOLOGISTS LTD
PI CAMBRIDGE
PA BIDDER BUILDING, STATION RD, HISTON, CAMBRIDGE CB24 9LF, ENGLAND
SN 0022-0949
EI 1477-9145
J9 J EXP BIOL
JI J. Exp. Biol.
PD MAY
PY 2021
VL 224
IS 10
AR jeb233213
DI 10.1242/jeb.233213
PG 12
WC Biology; Zoology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics; Zoology
GA SR2LA
UT WOS:000660873700004
PM 33758022
DA 2025-06-11
ER

PT J
AU Bianco, A
   Pinci, S
   Tiribelli, C
   Bellarosa, C
AF Bianco, Annalisa
   Pinci, Serena
   Tiribelli, Claudio
   Bellarosa, Cristina
TI Life-Long Hyperbilirubinemia Exposure and Bilirubin Priming Prevent
   In Vitro Metabolic Damage
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Article
DE Bilirubin; life-long hyperbilirubinemia; metabolic damage; apoptosis;
   inflammation; fibrosis; ER-stress
AB Background: Unconjugated bilirubin (UCB) is more than the final product of heme catabolism. Mildly elevated systemic bilirubin concentrations, such as in Gilbert syndrome (GS), protect against various oxidative stress-mediated and metabolic diseases, including cardiovascular disease, type 2 diabetes mellitus, metabolic syndrome, cancer, and age-related disease. The Gunn rat is an animal model of hereditary hyperbilirubinemia widely used in assessing the effect of high serum bilirubin concentration in various organs. The present work aims to understand if life-long hyperbilirubinemia and bilirubin-priming might contribute to protection against atherosclerosis and diabetic nephropathy (DN) at the cellular level.
   Methods: Primary aortic endothelial cells and podocytes obtained from hyperbilirubinemic homozygous jj and normobilirubinemic heterozygous Nj Gunn rats were exposed to Palmitic Acid (PA) and Angiotensin II (Ang II), respectively, and the effects on cell viability and the activation of damage-related metabolic pathways evaluated. Results were validated on immortalized H5V and HK2 cells exposed to damage after UCB pretreatment.
   Results: In both primary cell models, cells obtained from jj Gunn rats showed as significantly higher than Nj Gunn rats at any dose of the toxic agent. Reduction in CHOP expression and IL-6 release was observed in jj primary aortic endothelial cells exposed to PA compared to Nj cells. The same occurred on H5V pretreated with Unconjugated bilirubin. Upon Ang II treatment, primary podocytes from jj Gunn rats showed lower DNA fragmentation, cleaved caspase-3, and cleaved PARP induction than primary podocytes from Nj Gunn rats. In HK2 cells, the induction by Ang II of HIF-1 alpha and LOXl2 was significantly reduced by UCB pretreatment.
   Conclusion: Our data suggest that in models of atherosclerosis and DN life-long hyperbilirubinemia exposure or bilirubin-priming significantly contribute to decrease the injury by enhancing thecellular defensive response,
C1 [Bianco, Annalisa; Pinci, Serena; Tiribelli, Claudio; Bellarosa, Cristina] Italian Liver Fdn FIF, Trieste, Italy.
   [Bianco, Annalisa; Pinci, Serena] Univ Trieste, Dept Life Sci, Trieste, Italy.
C3 University of Trieste
RP Bellarosa, C (corresponding author), Italian Liver Fdn FIF, Trieste, Italy.
EM cristina.bellarosa@fegato.it
RI Pinci, Serena/IQS-3152-2023; Tiribelli, Claudio/A-4716-2014
OI Tiribelli, Claudio/0000-0001-6596-7595; Bellarosa,
   Cristina/0000-0002-2865-2575; Pinci, Serena/0009-0004-7730-1730
FU Beneficentia Stiftung; Banca d'Italia; FIF
FX This work has been supported in part by Beneficentia Stiftung, Banca
   d'Italia, and FIF internal grants.
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NR 61
TC 5
Z9 5
U1 0
U2 8
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD MAR 12
PY 2021
VL 12
AR 646953
DI 10.3389/fphar.2021.646953
PG 13
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA RC2NW
UT WOS:000632642400001
PM 33776779
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Lake, JA
   Papah, MB
   Abasht, B
AF Lake, Juniper A.
   Papah, Michael B.
   Abasht, Behnam
TI Increased Expression of Lipid Metabolism Genes in Early Stages of Wooden
   Breast Links Myopathy of Broilers to Metabolic Syndrome in Humans
SO GENES
LA English
DT Article
DE wooden breast; broilers; myopathy; breast muscle; meat quality
ID GENOME-WIDE ASSOCIATION; ENDOPLASMIC-RETICULUM STRESS; ANKYRIN REPEAT
   PROTEIN; SKELETAL-MUSCLE; PPAR-GAMMA; LIPOPROTEIN-LIPASE;
   INSULIN-RESISTANCE; MAJOR CHANGES; ER STRESS; BINDING
AB Wooden breast is a muscle disorder affecting modern commercial broiler chickens that causes a palpably firm pectoralis major muscle and severe reduction in meat quality. Most studies have focused on advanced stages of wooden breast apparent at market age, resulting in limited insights into the etiology and early pathogenesis of the myopathy. Therefore, the objective of this study was to identify early molecular signals in the wooden breast transcriptional cascade by performing gene expression analysis on the pectoralis major muscle of two-week-old birds that may later exhibit the wooden breast phenotype by market age at 7 weeks. Biopsy samples of the left pectoralis major muscle were collected from 101 birds at 14 days of age. Birds were subsequently raised to 7 weeks of age to allow sample selection based on the wooden breast phenotype at market age. RNA-sequencing was performed on 5 unaffected and 8 affected female chicken samples, selected based on wooden breast scores (0 to 4) assigned at necropsy where affected birds had scores of 2 or 3 (mildly or moderately affected) while unaffected birds had scores of 0 (no apparent gross lesions). Differential expression analysis identified 60 genes found to be significant at an FDR-adjusted p-value of 0.05. Of these, 26 were previously demonstrated to exhibit altered expression or genetic polymorphisms related to glucose tolerance or diabetes mellitus in mammals. Additionally, 9 genes have functions directly related to lipid metabolism and 11 genes are associated with adiposity traits such as intramuscular fat and body mass index. This study suggests that wooden breast disease is first and foremost a metabolic disorder characterized primarily by ectopic lipid accumulation in the pectoralis major.
C1 [Lake, Juniper A.] Univ Delaware, Ctr Bioinformat & Computat Biol, Newark, DE 19711 USA.
   [Papah, Michael B.; Abasht, Behnam] Univ Delaware, Dept Anim & Food Sci, Newark, DE 19716 USA.
C3 University of Delaware; University of Delaware
RP Abasht, B (corresponding author), Univ Delaware, Dept Anim & Food Sci, Newark, DE 19716 USA.
EM dnovick@udel.edu; papah@udel.edu; abasht@udel.edu
RI Babak, Michael/AAJ-1448-2021
OI Lake, Juniper Ada/0000-0001-7628-5645; Babak Papah,
   Michael/0000-0003-0306-7510
FU U.S. Department of Agriculture, Agriculture, and Food Research
   Initiative competitive grant [2016-67015-25027]
FX This research was funded by the U.S. Department of Agriculture,
   Agriculture, and Food Research Initiative competitive grant number
   2016-67015-25027.
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NR 133
TC 35
Z9 38
U1 0
U2 5
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2073-4425
J9 GENES-BASEL
JI Genes
PD OCT
PY 2019
VL 10
IS 10
AR 746
DI 10.3390/genes10100746
PG 17
WC Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Genetics & Heredity
GA JP6UA
UT WOS:000498397100017
PM 31557856
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Liu, GM
   Daneshgari, F
AF Liu, Guiming
   Daneshgari, Firouz
TI Diabetic bladder dysfunction
SO CHINESE MEDICAL JOURNAL
LA English
DT Review
DE diabetes; bladder dysfunction; cystopathy; complications
ID LOWER URINARY-TRACT; OXIDATIVE STRESS; URODYNAMIC FINDINGS;
   SMOOTH-MUSCLE; RISK-FACTORS; RAT MODEL; METABOLIC-SYNDROME; CYSTOPATHY;
   MELLITUS; COMPLICATIONS
AB Objective To review studies on diabetic bladder dysfunction (DBD), a common and bothersome complication of diabetes mellitus.
   Data sources We performed a search of the English literature through PubMed. The key words used were "diabetes" and "bladder dysfunction" or "cystopathy". Our own data and perspective are included in the discussion.
   Study selection Studies containing data relevant to DBD were selected. Because of the limited length of this article, we also referenced reviews that contain comprehensive amalgamations of relevant literature.
   Results The classic symptoms of DBD are decreased bladder sensation, increased bladder capacity, and impaired bladder emptying with resultant elevated post-void residual urine. However, recent clinical and experimental evidence indicate a strong presence of storage problems such as urge incontinence in diabetes. Recent studies of DBD in animal models of type 1 diabetes have revealed temporal effects of diabetes, causing an early phase of compensatory bladder function and a later phase of deconnpensated bladder function. The pathophysiology of DBD is multifactorial, including disturbances of the detrusor, urothelium, autonomic nerves, and urethra. Polyuria and hyperglycemia play important but distinctive roles in induction of bladder dysfunction in type 1 diabetes. Polyuria causes significant bladder hypertrophy in the early stage of diabetes, whereas oxidative stress in the bladder caused by chronic hyperglycemia may play an important role in the late stage failure of bladder function.
   Conclusions DBD includes time-dependent and mixed manifestations. The pathological alterations include muscle, nerve, and urothelium. Polyuria and hyperglycemia independently contribute to the pathogenesis of DBD. Treatments for DBD are limited. Future clinical studies on DBD in type 1 and type 2 diabetes should be investigated separately. Animal studies of DBD in type 2 diabetes are needed, from the natural history to mechanisms. Further understanding of the molecular mechanisms of DBD will provide multiple potential targets for therapeutic intervention.
C1 [Liu, Guiming; Daneshgari, Firouz] Case Western Reserve Univ, Sch Med, Univ Hosp Case Med Ctr, Inst Urol, Cleveland, OH 44106 USA.
   [Liu, Guiming; Daneshgari, Firouz] Case Western Reserve Univ, Sch Med, Dept Urol, Cleveland, OH 44106 USA.
C3 University System of Ohio; Case Western Reserve University; Case Western
   Reserve University Hospital; University System of Ohio; Case Western
   Reserve University
RP Liu, GM (corresponding author), Case Western Reserve Univ, Sch Med, Univ Hosp Case Med Ctr, Inst Urol, 11100 Euclid Ave, Cleveland, OH 44106 USA.
EM guiming.liu@case.edu
RI Liu, Guiming/AAM-2688-2020
FU American Diabetes Association [1-10-JF-29]; NIH/NIDDK [R01 DK083733]
FX This work was supported by grants from American Diabetes Association
   (No. 1-10-JF-29, to Liu G), and NIH/NIDDK (No. R01 DK083733, to
   Daneshgari F).
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NR 90
TC 68
Z9 75
U1 1
U2 20
PU MEDKNOW PUBLICATIONS & MEDIA PVT LTD
PI MUMBAI
PA B-9, KANARA BUSINESS CENTRE, OFF LINK RD, GHAKTOPAR-E, MUMBAI, 400075,
   INDIA
SN 0366-6999
J9 CHINESE MED J-PEKING
JI Chin. Med. J.
PD APR 5
PY 2014
VL 127
IS 7
BP 1357
EP 1364
DI 10.3760/cma.j.issn.0366-6999.20132407
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA AE9JY
UT WOS:000334325300029
PM 24709194
OA gold
DA 2025-06-11
ER

PT J
AU Savino, A
   Pelliccia, P
   Giannini, C
   de Giorgis, T
   Cataldo, I
   Chiarelli, F
   Mohn, A
AF Savino, Alessandra
   Pelliccia, Piernicola
   Giannini, Cosimo
   de Giorgis, Tommaso
   Cataldo, Ivana
   Chiarelli, Francesco
   Mohn, Angelika
TI Implications for kidney disease in obese children and adolescents
SO PEDIATRIC NEPHROLOGY
LA English
DT Article
DE Kidney disease; Renal function impairment; Obesity; Insulin resistance;
   Children; Adolescents; Nitric oxide; Oxidative stress
ID GLOMERULAR-FILTRATION-RATE; CARDIOVASCULAR RISK-FACTORS; URINARY ALBUMIN
   EXCRETION; IMPAIRED GLUCOSE-TOLERANCE; NOCTURNAL BLOOD-PRESSURE; SERUM
   CYSTATIN-C; INSULIN-RESISTANCE; NITRIC-OXIDE; METABOLIC SYNDROME; RENAL
   MANIFESTATIONS
AB Increasing attention has been focused on the implications of obesity in adults on the development of kidney disease, but data on the obese pediatric population are lacking. The aim of this study was to investigate whether changes in various renal function indexes/markers, as expressed by the glomerular filtration rate [GFR, as estimated by the Schwartz formula (eGFR)], serum cystatin C (CysC) level, albumin excretion rate (AER), and modifications in nitric oxide (NO; an important modulator of renal function and morphology), urinary isoprostanes (markers of oxidative stress), and blood pressure (BP), can be detected in obese children and adolescents when compared to normal weight controls. Blood and urinary samples were collected to evaluate markers of renal function, serum and urinary NO, and urinary isoprostanes in 107 obese Caucasian subjects and 50 controls. Ambulatory BP monitoring (ABPM) was performed in all cases. Obesity was expressed by the body mass index standard deviation score (SDS-BMI), and insulin resistance by the homeostasis model assessment of insulin resistance (HOMA-IR). CysC and eGFR did not significantly differ between the two groups; AER was increased in obese children. CysC and GFR were related to HOMA-IR, and AER was related to HOMA-IR and SDS-BMI. Obese subjects had reduced NO levels and increased urinary isoprostanes and BP measurements; all three parameters were related to SDS-BMI and insulin resistance. ABPM showed an increased incidence of hypertension and non-dipping in the obese group. Based on our comparison of obese and nonobese children, we conclude that renal involvement is not an early clinically evident manifestation of adiposity in childhood, since no overt changes in eGFR and only a mild albuminuria were detected. A longer exposure to obesity is probably needed before renal function impairment appears.
C1 [Savino, Alessandra] Univ G dAnnunzio, Osped Policlin SS Annunziata, I-66013 Chieti, Italy.
   [Pelliccia, Piernicola; Giannini, Cosimo; de Giorgis, Tommaso; Chiarelli, Francesco; Mohn, Angelika] Univ G dAnnunzio, Dept Pediat, I-66013 Chieti, Italy.
   [Cataldo, Ivana] Osped Policlin SS Annunziata, Dept Pathol, Chieti, Italy.
C3 G d'Annunzio University of Chieti-Pescara; G d'Annunzio University of
   Chieti-Pescara
RP Savino, A (corresponding author), Univ G dAnnunzio, Osped Policlin SS Annunziata, I-66013 Chieti, Italy.
EM alessavino@katamail.com
RI ; Giannini, Cosimo/K-9631-2016
OI CATALDO, Ivana/0000-0003-2032-2085; Giannini, Cosimo/0000-0002-2904-2744
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NR 79
TC 35
Z9 40
U1 0
U2 8
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0931-041X
EI 1432-198X
J9 PEDIATR NEPHROL
JI Pediatr. Nephrol.
PD MAY
PY 2011
VL 26
IS 5
BP 749
EP 758
DI 10.1007/s00467-010-1659-y
PG 10
WC Pediatrics; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics; Urology & Nephrology
GA 739JI
UT WOS:000288712800012
PM 21308381
DA 2025-06-11
ER

PT J
AU Gupte, AA
   Liu, JZ
   Ren, Y
   Minze, LJ
   Wiles, JR
   Collins, AR
   Lyon, CJ
   Pratico, D
   Finegold, MJ
   Wong, ST
   Webb, P
   Baxter, JD
   Moore, DD
   Hsueh, WA
AF Gupte, Anisha A.
   Liu, Joey Z.
   Ren, Yuelan
   Minze, Laurie J.
   Wiles, Jessica R.
   Collins, Alan R.
   Lyon, Christopher J.
   Pratico, Domenico
   Finegold, Milton J.
   Wong, Stephen T.
   Webb, Paul
   Baxter, John D.
   Moore, David D.
   Hsueh, Willa A.
TI Rosiglitazone Attenuates Age- and Diet-Associated Nonalcoholic
   Steatohepatitis in Male Low-Density Lipoprotein Receptor Knockout Mice
SO HEPATOLOGY
LA English
DT Article
ID FATTY LIVER-DISEASE; HEPATIC STEATOSIS; RISK-FACTORS; PROGRESSION;
   FIBROSIS; PIOGLITAZONE; MITOCHONDRIA; PREDICTORS; MECHANISMS; PLACEBO
AB Nonalcoholic fatty liver disease (NAFLD) is a common complication of obesity that can progress to nonalcoholic steatohepatitis (NASH), a serious liver pathology that can advance to cirrhosis The mechanisms responsible for NAFLD progression to NASH remain unclear Lack of a suitable animal model that faithfully recapitulates the pathophysiology of human NASH is a major obstacle in delineating mechanisms responsible for progression of NAFLD to NASH and, thus, development of better treatment strategies We identified and characterized a novel mouse model, middle-aged male low-density lipoprotein receptor (LDLR)(-/-) mice fed a high-fat diet (HFD), which developed NASH associated with four of five metabolic syndrome (MS) components In these mice, as observed in humans, liver steatosis and oxidative stress promoted NASH development Aging exacerbated the HFD-induced NASH such that liver steatosis, inflammation, fibrosis, oxidative stress, and liver injury markers were greatly enhanced in middle-aged versus young LDLR-/- mice Although expression of genes mediating fatty acid oxidation and antioxidant responses were up-regulated in young LDLR-/- mice fed HFD, they were drastically reduced in MS mice However, similar to recent human trials, NASH was partially attenuated by an insulin-sensitizing peroxisome proliferator-activated receptor-gamma (PPAR gamma) ligand, rosiglitazone In addition to expected improvements in MS, newly identified mechanisms of PPAR gamma ligand effects included stimulation of antioxidant gene expression and mitochondrial beta-oxidation, and suppression of inflammation and fibrosis LDLR-deficiency promoted NASH, because middle-aged C57BL/6 mice fed HFD did not develop severe inflammation and fibrosis, despite increased steatosis Conclusion MS mice represent an ideal model to investigate NASH in the context of MS, as commonly occurs in human disease, and NASH development can be substantially attenuated by PPAR gamma activation, which enhances beta-oxidation (HEPATOLOGY 2010,52 2001-2011)
C1 [Gupte, Anisha A.; Liu, Joey Z.; Ren, Yuelan; Minze, Laurie J.; Wiles, Jessica R.; Collins, Alan R.; Lyon, Christopher J.; Webb, Paul; Baxter, John D.; Hsueh, Willa A.] Methodist Hosp, Res Inst, Ctr Diabet Res, Weill Cornell Med Coll, Houston, TX 77030 USA.
   [Pratico, Domenico] Temple Univ, Sch Med, Dept Pharmacol, Philadelphia, PA USA.
   [Finegold, Milton J.] Texas Childrens Hosp, Dept Pathol, Houston, TX 77030 USA.
   [Wong, Stephen T.] Methodist Hosp, Res Inst, Ctr Bioengn & Infomat, Weill Cornell Med Coll, Houston, TX 77030 USA.
   [Moore, David D.] Baylor Coll Med, Dept Mol & Cellular Biol, Houston, TX 77030 USA.
C3 Houston Methodist; Cornell University; Pennsylvania Commonwealth System
   of Higher Education (PCSHE); Temple University; Baylor College of
   Medicine; Baylor College Medical Hospital; Houston Methodist; Cornell
   University; Baylor College of Medicine
RP Hsueh, WA (corresponding author), Methodist Hosp, Res Inst, Ctr Diabet Res, Weill Cornell Med Coll, 6535 Fannin, Houston, TX 77030 USA.
RI Webb, Paul/MNV-3289-2025; Moore, David/B-8517-2011; Pratico,
   Domenico/ABA-9590-2020; Xiao, Liuling/AFR-2506-2022; Gupte,
   Anisha/D-6756-2015
OI Gupte, Anisha/0000-0002-5173-1773
FU National Institutes of Health (NIH) [R01 HL075171]; Dailehi Sankyo
FX Supported by National Institutes of Health (NIH) grant R01 HL075171 (to
   W A H)Potential conflict of interest Dr Hsuch is a consultant for and is
   on the speakers bureau of GlaxoSmithKline She is also on the speakers
   bureau of Merck and received grants from Dailehi Sankyo Dr Baxter owns
   stock in is a consultant for and advises Karo Bio
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NR 29
TC 85
Z9 98
U1 1
U2 17
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0270-9139
EI 1527-3350
J9 HEPATOLOGY
JI Hepatology
PD DEC
PY 2010
VL 52
IS 6
BP 2001
EP 2011
DI 10.1002/hep.23941
PG 11
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 690RP
UT WOS:000285023700016
PM 20938947
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Aronis, A
   Madar, Z
   Tirosh, O
AF Aronis, Anna
   Madar, Zecharia
   Tirosh, Oren
TI Lipotoxic effects of triacylglycerols in J774.2 macrophages
SO NUTRITION
LA English
DT Article
DE lipids; atherosclerosis; oxidative stress; apoptosis; necrosis
ID PALMITATE-INDUCED APOPTOSIS; INDUCED OXIDATIVE STRESS; FOAM
   CELL-FORMATION; FATTY-ACIDS; PLAQUE RUPTURE; IN-VITRO; T-CELLS;
   ATHEROSCLEROSIS; DEATH; MECHANISMS
AB Objective: Triacylglycerols (TGs) are being considered as an independent risk factor in atherosclerosis and metabolic syndrome, acting by dysregulation of the TG/high-density lipoprotein axis. Accumulation of lipids in subendothelial space attracts macrophages, leading to atherosclerotic plaque formation and increased plaque instability due to formation of foam cells and macrophage death. The aim of this study was to evaluate lipotoxic effects in macrophages caused by TG uptake.
   Methods: J774.2 macrophages were exposed to soybean or olive oil-based lipid emulsions as a source of TGs (1 mg/mL) in a presence or absence of lipase inhibitor paraoxon (20 mu M) or to bovine serum albumin-complexed palmitic (150 mu M), linoleic (600 mu M), and oleic (600 mu M) fatty acids.
   Results: The results demonstrated accumulation of TGs, G(1)/S arrest, and cell death with necrotic morphologic features after exposure to TG emulsions. These effects were prevented by treatment with an antioxidant N-acetyl-cysteine (0.5 mM). Paraoxon inhibited intracellular TG degradation but did not prevent lipotoxicity and cell death. Olive oil TG triggered macrophage death in a manner similar to soybean oil. Treatment of the macrophages with free fatty acid, mainly with palmitic acid, showed a reactive oxygen species-independent cell death pathway, which was different from that of TG and was not prevented by N-acetyl-cysteine.
   Conclusion: This study shows a direct lipotoxic pathway for TG molecules in macrophages, which is not associated with degradation of TG molecule to free fatty acids. This study for the first time can explain at a cellular level how TGs as an independent risk factor aggravate atherosclerotic outcomes. (c) 2008 Elsevier Inc. All rights reserved.
C1 [Aronis, Anna; Madar, Zecharia; Tirosh, Oren] Hebrew Univ Jerusalem, Sch Nutr Sci, Inst Biochem Food Sci & Nutr, Fac Agr Food & Environm Qual Sci, IL-76100 Rehovot, Israel.
C3 Hebrew University of Jerusalem
RP Tirosh, O (corresponding author), Hebrew Univ Jerusalem, Sch Nutr Sci, Inst Biochem Food Sci & Nutr, Fac Agr Food & Environm Qual Sci, IL-76100 Rehovot, Israel.
EM otirosh@agri.huji.ac.il
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NR 61
TC 28
Z9 29
U1 0
U2 6
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0899-9007
J9 NUTRITION
JI Nutrition
PD FEB
PY 2008
VL 24
IS 2
BP 167
EP 176
DI 10.1016/j.nut.2007.10.017
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 254BD
UT WOS:000252560400009
PM 18165129
DA 2025-06-11
ER

PT J
AU Palming, J
   Sjöholm, K
   Jernås, M
   Lystig, TC
   Gummesson, A
   Romeo, S
   Lönn, L
   Carlsson, B
   Carlsson, LMS
AF Palming, Jenny
   Sjoholm, Kajsa
   Jernas, Margareta
   Lystig, Theodore C.
   Gummesson, Anders
   Romeo, Stefano
   Lonn, Lars
   Carlsson, Bjorn
   Carlsson, Lena M. S.
TI The expression of NAD(P)H:quinone oxidoreductase 1 is high in human
   adipose tissue, reduced by weight loss, and correlates with adiposity,
   insulin sensitivity, and markers of liver dysfunction
SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Article
ID NONALCOHOLIC FATTY LIVER; GENETIC POLYMORPHISMS; METABOLIC SYNDROME;
   HEPATIC STEATOSIS; OXIDATIVE STRESS; HUMAN ADIPOCYTES; DT-DIAPHORASE;
   CELL-SIZE; RESISTANCE; POPULATION
AB Context: We have previously identified nicotinamide adenine dinucleotide phosphate: quinone oxidoreductase 1 (NQO1), an enzyme involved in the protection against oxidative stress, as a gene predominantly expressed in human adipocytes. Studies in mice deficient in NQO1 activity suggest that NQO1 may also play an important role in metabolism.
   Objective: The aim of this study was to explore the expression and regulation of NQO1 in human adipose tissue (AT) and isolated adipocytes.
   Patients and Results: The high expression of NQO1 in adipocytes was verified in human adipocytes and AT by real-time PCR. DNA microarray analysis showed that NQO1 was expressed at higher levels in large compared with small adipocytes, isolated from the same fat biopsy. Furthermore, NQO1 mRNA levels were positively correlated with adipocyte size (n = 7; P < 0.002). During an 18-wk diet regime (n = 24; mean weight loss 27 kg), the NQO1 expression in human sc AT was down-regulated (P < 0.0001), and mRNA levels correlated with body mass index (P = 0.0005), sc, and total abdominal AT areas, as determined by computerized tomography (P < 0.0001, both) and metabolic parameters. NQO1 mRNA levels were also positively correlated with aspartate aminotransferase (P = 0.0028) and alanine aminotransferase (P = 0.0219), markers known to be associated with severity of hepatic steatosis.
   Conclusions: NQO1 is highly expressed in human AT, particularly in large adipocytes. AT NQO1 expression is reduced during diet-induced weight loss, and the expression levels positively correlate with adiposity, glucose tolerance, and markers of liver dysfunction. Together, these findings indicate a role for NQO1 in the metabolic complications of human obesity.
C1 Univ Gothenburg, Sahlgrenska Acad, Dept Radiol, SE-41345 Gothenburg, Sweden.
   Univ Gothenburg, Sahlgrenska Acad, Dept Mol & Clin Med, SE-41345 Gothenburg, Sweden.
   Univ Gothenburg, Sahlgrenska Acad, Sahlgrenska Ctr Cardiovasc & Metab Res, SE-41345 Gothenburg, Sweden.
   Univ Texas, SW Med Ctr, Donald W Reynolds Cardiovasc Clin Res Ctr, Dallas, TX 75390 USA.
C3 University of Gothenburg; University of Gothenburg; University of
   Gothenburg; University of Texas System; University of Texas Dallas;
   University of Texas Southwestern Medical Center Dallas
RP Sjöholm, K (corresponding author), Vita Straket 15, SE-41345 Gothenburg, Sweden.
EM kajsa.sjoholm@medic.gu.se
RI Carlsson Ekander, Lena/F-7570-2018; Sjoholm, Kajsa/IQV-6550-2023; romeo,
   stefano/L-6861-2015; Lystig, Theodore/E-4149-2015
OI Carlsson Ekander, Lena/0000-0003-4145-6242; Gummesson,
   Anders/0000-0003-0024-960X; Sjoholm, Kajsa/0000-0003-0146-8193; romeo,
   stefano/0000-0001-9168-4898; Lystig, Theodore/0000-0002-4523-0761; Lonn
   (Lonn), Lars/0000-0003-2089-5211
CR [Anonymous], 1992, Methods in Lignin Chemistry
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NR 40
TC 58
Z9 60
U1 0
U2 6
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0021-972X
EI 1945-7197
J9 J CLIN ENDOCR METAB
JI J. Clin. Endocrinol. Metab.
PD JUN
PY 2007
VL 92
IS 6
BP 2346
EP 2352
DI 10.1210/jc.2006-2476
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 176CX
UT WOS:000247061700057
PM 17405841
OA Bronze
DA 2025-06-11
ER

PT J
AU Forester, BR
   Brostek, A
   Schuhler, B
   Gonzalez-Vicente, A
   Garvin, JL
AF Forester, Beau R.
   Brostek, Autumn
   Schuhler, Brett
   Gonzalez-Vicente, Agustin
   Garvin, Jeffrey L.
TI Angiotensin II-stimulated proximal nephron superoxide production and
   fructose-induced salt-sensitive hypertension
SO AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
LA English
DT Article
DE blood pressure; kidney; oxidative stress
ID THICK ASCENDING LIMB; BLOOD-PRESSURE; INSULIN-RESISTANCE; METABOLIC
   SYNDROME; TUBULE; LOSARTAN; HEMODYNAMICS; TELMISARTAN; ABSORPTION;
   EXPRESSION
AB Angiotensin II (ANG II) increases proximal tubule superoxide (O-2(-)) production more in rats fed a 20% fructose normal-salt diet compared with rats fed a 20% glucose normal-salt diet. A 20% fructose high-salt diet (FHS) increases systolic blood pressure (SBP), whereas a 20% glucose high-salt diet (GHS) does not. However, it is unclear whether FHS enhances ANG II-induced oxidative stress in proximal tubules and whether this contributes to increases in blood pressure in this model. We hypothesized that FHS augments the ability of ANG II to stimulate O-2(-) production by proximal tubules, and this contributes to fructose-induced salt-sensitive hypertension. We measured SBP in male Sprague-Dawley rats fed FHS and GHS and determined the effects of 3 mM tempol and 50 mg/kg losartan for 7 days. We then measured basal and ANG II-stimulated (3.7 x 10(-8) M) O-2(-) production by proximal tubule suspensions and the role of protein kinase C. FHS increased SBP by 27 +/- 5 mmHg (n = 6, P < 0.006) but GHS did not. Rats fed FHS + tempol and GHS + tempol showed no significant increases in SBP. ANG II increased O-2(-) production by 11 +/- 1 relative light units/mu g protein/s in proximal tubules from FHS-fed rats (n = 6, P < 0.05) but not in tubules from rats fed GHS. ANG II did not significantly stimulate O-2(-) production by proximal tubules from rats fed FHS + tempol or FHS + losartan. The protein kinase C inhibitor G & ouml;6976 blunted ANG II-stimulated O-2(-) production. In conclusion, FHS enhances the sensitivity of proximal tubule O-2(-) production to ANG II, and this contributes to fructose-induced salt-sensitive hypertension.
C1 [Forester, Beau R.; Brostek, Autumn; Schuhler, Brett; Gonzalez-Vicente, Agustin; Garvin, Jeffrey L.] Case Western Reserve Univ, Cleveland, OH 44106 USA.
   [Gonzalez-Vicente, Agustin] Glickman Urol & Kidney Inst, Dept Nephrol & Hypertens, Cleveland Clin, Cleveland, OH USA.
C3 University System of Ohio; Case Western Reserve University; Cleveland
   Clinic Foundation
RP Garvin, JL (corresponding author), Case Western Reserve Univ, Cleveland, OH 44106 USA.
EM jlg5@case.edu
RI Gonzalez-Vicente, Agustin/K-2773-2018
OI Gonzalez-Vicente, Agustin/0000-0002-3682-0815; Forester,
   Beau/0000-0001-7517-4636
FU National Institutes of Health [HL128053, DK128304]
FX This work was supported in part by National Institutes of Health Grants
   HL128053 (to J.L.G.) and DK128304 (to A.G.-V.).
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NR 51
TC 2
Z9 2
U1 1
U2 7
PU AMER PHYSIOLOGICAL SOC
PI Rockville
PA 6120 Executive Blvd, Suite 600, Rockville, MD, UNITED STATES
SN 1931-857X
EI 1522-1466
J9 AM J PHYSIOL-RENAL
JI Am. J. Physiol.-Renal Physiol.
PD FEB 7
PY 2024
VL 326
IS 2
BP F249
EP F256
DI 10.1152/ajprenal.00289.2023
PG 8
WC Physiology; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology; Urology & Nephrology
GA HL2W2
UT WOS:001159604200001
PM 38059297
DA 2025-06-11
ER

PT J
AU Chen, WG
   Wang, JB
   Wang, XH
   Chang, P
   Liang, M
AF Chen, Weiguo
   Wang, Jianbang
   Wang, Xihui
   Chang, Pan
   Liang, Meng
TI Knockdown of hypoxia-inducible factor 1-alpha (HIF1α) interferes with
   angiopoietin-like protein 2 (ANGPTL2) to attenuate high
   glucose-triggered hypoxia/reoxygenation injury in cardiomyocytes
SO BIOENGINEERED
LA English
DT Article
DE HIF1A; ANGPTL2; hypoxia; reoxygenation injury; cardiomyocytes
ID CORONARY-HEART-DISEASE; GENE-EXPRESSION; MYOCARDIAL-INFARCTION;
   METABOLIC SYNDROME; ENDOTHELIAL-CELLS; REACTIVE OXYGEN; INFLAMMATION;
   ACTIVATION; RISK; NRF2
AB To investigate the role of hypoxia-inducible factor 1-alpha (HIF1A) in hypoxia/reoxygenation (H/R) injury of cardiomyocytes induced by high glucose (HG). The in vitro model of coronary heart disease with diabetes was that H9c2 cells were stimulated by H/R and HG. Quantitative reverse transcription PCR (RT-qPCR) and Western blot analysis were used to detect the expression of HIF1A and angiopoietin-like protein 2 (ANGPTL2) in H9c2 cells. Cell viability and apoptosis were, respectively, estimated by Cell Counting Kit 8 (CCK-8) and TUNEL assays. Lactate dehydrogenase (LDH) activity, inflammation and oxidative stress were in turn detected by their commercial assay kits. Luciferase reporter assay and chromatin immunoprecipitation (ChIP) assay were used to confirm the association between HIF1A and ANGPTL2 promoter. The expression of nuclear factor E2-related factor 2 (Nrf2)/heme oxygenase 1 (HO-1) pathway-related proteins and apoptosis-related proteins were also detected by Western blot analysis. As a result, ANGPTL2 expression was upregulated in H9c2 cells induced by HG or/and H/R. ANGPTL2 positively modulated HIF1A expression in H9c2 cells. HG or/and H/R suppressed the cell viability and promoted apoptosis, inflammatory response and oxidative stress levels in H9c2 cells. However, the knockdown of ANGPTL2 could reverse the above phenomena in H/R-stimulated-H9c2 cells through activation of Nrf2/HO-1 pathway. HIF1A transcriptionally activated ANGPTL2 expression. The effect of knockdown of ANGPTL2 on H/R triggered-H9c2 cells was weakened by HIF1A overexpression. In conclusion, knockdown of HIF1A downregulated ANGPTL2 to alleviate H/R injury in HG-induced H9c2 cells by activating the Nrf2/HO-1 pathway.
C1 [Chen, Weiguo; Wang, Jianbang; Wang, Xihui; Liang, Meng] Xian Med Univ, Affiliated Hosp 2, Dept Cardiol, 167 Fangdong St, Xian 710038, Shaanxi, Peoples R China.
   [Chang, Pan] Xian Med Univ, Affiliated Hosp 2, Expt Ctr, Xian, Peoples R China.
C3 Xi'an Medical University; Xi'an Medical University
RP Liang, M (corresponding author), Xian Med Univ, Affiliated Hosp 2, Dept Cardiol, 167 Fangdong St, Xian 710038, Shaanxi, Peoples R China.
EM liangmeng102@126.com
FU Natural Science Foundation of Shaanxi Province [2021JQ-787]; Health
   Science Foundation of Shaanxi Province [2021E023]
FX Natural Science Foundation of Shaanxi Province (2021JQ-787); Health
   Science Foundation of Shaanxi Province (2021E023).
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NR 62
TC 12
Z9 12
U1 0
U2 16
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 2165-5979
EI 2165-5987
J9 BIOENGINEERED
JI Bioengineered
PD JAN 1
PY 2022
VL 13
IS 1
BP 1476
EP 1490
DI 10.1080/21655979.2021.2019874
PG 15
WC Biotechnology & Applied Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology
GA XZ3IR
UT WOS:000737549800001
PM 34974813
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Tarhonska, K
   Raimondi, S
   Specchia, C
   Wieczorek, E
   Reszka, E
   Krol, MB
   Gromadzinska, J
   Wasowicz, W
   Socha, K
   Borawska, MH
   Jablonska, E
AF Tarhonska, Kateryna
   Raimondi, Sara
   Specchia, Claudia
   Wieczorek, Edyta
   Reszka, Edyta
   Krol, Magdalena Beata
   Gromadzinska, Jolanta
   Wasowicz, Wojciech
   Socha, Katarzyna
   Borawska, Maria Halina
   Jablonska, Ewa
TI Association of allelic combinations in selenoprotein and redox related
   genes with markers of lipid metabolism and oxidative stress-multimarkers
   analysis in a cross-sectional study
SO JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
LA English
DT Article
DE Selenium; Selenoproteins; Genetic polymorphisms; Lipid metabolism;
   Energy metabolism
ID MANGANESE SUPEROXIDE-DISMUTASE; NUCLEOTIDE POLYMORPHISMS; PRO198LEU
   POLYMORPHISM; INSULIN-RESISTANCE; BREAST-CANCER; SELENIUM;
   GLUTATHIONE-PEROXIDASE-1; OBESITY; SUPPLEMENTATION; CONTRIBUTES
AB Background: Selenium (Se) and selenoproteins have been shown to be involved in lipid metabolism mainly due to their ability to modulate redox homeostasis in adipose tissue. The underlying mechanisms are yet to be evaluated. In the light of few data related to the association between polymorphic variants of selenoprotein encoding genes and metabolic syndrome or obesity in humans, the role of selenoprotein polymorphisms in lipid metabolism remains unclear. The aim of this study was to investigate the impact of allelic combination within selenoprotein and redox related genes on the markers of lipid metabolism and oxidative stress. Methods: The study comprised 441 healthy individuals from Poland, in the 18-74 year age group. Allelic combinations were investigated within the polymorphic variants of four selenoprotein encoding genes (GPX1 rs1050450, GPX4 rs713041, SELENOP rs3877899 and SELENOF rs5859) and the redox related gene (SOD2 rs4880). The impact of the most common allelic GPX1-GPX4-SELENOP-SELENOF-SOD2 combinations was assessed on the following markers: triglycerides (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), glutathione peroxidase activities (GPX1, GPX3), lipid peroxidation (as TBARS), ceruloplasmin (Cp) and superoxide dismutase 1 (SOD1). Results: Multivariable analysis revealed significant associations between three allelic combinations and markers of lipid metabolism, including HDL-C and TC/HDL-C ratio (AAAAa), LDL-C (aaAaa), and triglycerides (aaaaA), whereas two allelic combinations (aAaAA, aaaAA) were associated with GPX3 activity. Conclusion: This study confirms the possible implication of selenoproteins in lipid metabolism and warrants further research on specific allele combinations within selenoprotein and redox related genes in order to identify functional genetic combinations linked to metabolic phenotype.
C1 [Tarhonska, Kateryna; Wieczorek, Edyta; Reszka, Edyta; Jablonska, Ewa] Nofer Inst Occupat Med, Dept Translat Res, PL-91348 Lodz, Poland.
   [Raimondi, Sara] European Inst Oncol IEO, Ist Ricovero & Cura Carattere Sci IRCCS, Dept Expt Oncol, Mol & Pharmacoepidemiol Unit, Milan, Italy.
   [Specchia, Claudia] Univ Brescia, Dept Mol & Translat Med, I-25123 Brescia, Italy.
   [Krol, Magdalena Beata; Gromadzinska, Jolanta; Wasowicz, Wojciech] Nofer Inst Occupat Med, Dept Biol & Environm Monitoring, PL-91348 Lodz, Poland.
   [Socha, Katarzyna; Borawska, Maria Halina] Med Univ Bialystok, Fac Pharm, Dept Bromatol, Div Lab Med, PL-15222 Bialystok, Poland.
C3 Nofer Institute of Occupational Medicine; IRCCS European Institute of
   Oncology (IEO); Fondazione IRCCS Istituto Nazionale Tumori Milan;
   University of Brescia; Nofer Institute of Occupational Medicine; Medical
   University of Bialystok
RP Tarhonska, K (corresponding author), Nofer Inst Occupat Med, Dept Translat Res, Sw Teresy 8 St, PL-91348 Lodz, Poland.
EM kateryna.tarhonska@imp.lodz.pl; sara.raimondi@ieo.it;
   claudia.specchia@unibs.it; wieczorek@imp.lodz.pl;
   edyta.reszka@imp.lodz.pl; magdalena.krol@imp.lodz.pl;
   jolanta.gromadzinska@imp.lodz.pl; wojciech.wasowicz@imp.lodz.pl;
   katarzyna.socha@umb.edu.pl; borawska@umb.edu.pl; jablonska@imp.lodz.pl
RI Król, Magdalena/N-4759-2019; Tarhonska, Kateryna/AHD-2774-2022; Krol,
   Magdalena/H-3409-2016; Raimondi, Sara/J-5236-2016; Kasperczyk,
   Edyta/F-7057-2010; Jablonska, Ewa/F-6005-2010; Reszka, Edyta/F-6008-2010
OI Krol, Magdalena/0000-0001-7856-2968; Raimondi, Sara/0000-0003-4673-9049;
   Kasperczyk, Edyta/0000-0002-4390-2042; Jablonska,
   Ewa/0000-0002-3946-3964; Tarhonska, Kateryna/0000-0003-2940-0449;
   Reszka, Edyta/0000-0003-2153-4864
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NR 48
TC 6
Z9 6
U1 0
U2 16
PU ELSEVIER GMBH
PI MUNICH
PA HACKERBRUCKE 6, 80335 MUNICH, GERMANY
SN 0946-672X
EI 1878-3252
J9 J TRACE ELEM MED BIO
JI J. Trace Elem. Med. Biol.
PD JAN
PY 2022
VL 69
AR 126873
DI 10.1016/j.jtemb.2021.126873
EA OCT 2021
PG 7
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA WP2NB
UT WOS:000712973400006
PM 34695782
OA hybrid
DA 2025-06-11
ER

PT J
AU Gasparotto, J
   Somensi, N
   Bortolin, RC
   Girardi, CS
   Kunzler, A
   Rabelo, TK
   Schnorr, CE
   Moresco, KS
   Bassani, VL
   Yatsu, FKJ
   Vizzotto, M
   Raseira, MDCB
   Zanotto-Filho, A
   Moreira, JCF
   Gelain, DP
AF Gasparotto, Juciano
   Somensi, Nauana
   Bortolin, Rafael Calixto
   Girardi, Carolina Saibro
   Kunzler, Alice
   Rabelo, Thallita Kelly
   Schnorr, Carlos Eduardo
   Moresco, Karla Suzana
   Bassani, Valquiria Linck
   Yatsu, Francini Kiyono Jorge
   Vizzotto, Marcia
   Raseira, Maria do Carmo Bassols
   Zanotto-Filho, Alfeu
   Moreira, Jose Claudio Fonseca
   Gelain, Daniel Pens
TI Preventive supplementation with fresh and preserved peach attenuates
   CCl4-induced oxidative stress, inflammation and tissue damage
SO JOURNAL OF NUTRITIONAL BIOCHEMISTRY
LA English
DT Article
DE Peach; NF kappa B-p65; RAGE; Antioxidant; Anti-inflammatory; Carbon
   tetrachloride
ID KAPPA-B ACTIVATION; CARBON-TETRACHLORIDE; METABOLIC SYNDROME;
   LIVER-DAMAGE; IN-VITRO; INJURY; CAROTENOIDS; MARKERS; RAGE; VIVO
AB The present study was elaborated to comparatively evaluate the preventive effect of different peach-derived products obtained from preserved fruits (Syrup and Preserve Pulp Peach [PPP]) and from fresh peels and pulps (Peel and Fresh Pulp Peach [FPP]) in a model of liver/renal toxicity and inflammation induced by carbon tetrachloride (CCl4) in rats. Tissue damage (carbonyl, thiobarbituric acid reactive species and sulfhydril), antioxidant enzymes activity (catalase and superoxide dismutase) and inflammatory parameters [tumor necrosis factor (TNF)-alpha and interleukin (IL)-beta levels, and receptor for advanced glycation end-products (RAGE) and nuclear factor (NF)kappa B-p65 immunocontent] were investigated. Our findings demonstrated that Peel, PPP and FPP (200 or 400 mg/kg) daily administration by oral gavage for 30 days conferred a significant protection against CCl4-induced antioxidant enzymes activation and, most importantly, oxidative damage to lipids and proteins as well as blocked induction of inflammatory mediators such as TNF-alpha, IL-beta, RAGE and NF kappa B. This antioxidant/anti-inflammatory effect seems to be associated with the abundance of carotenoids and polyphenols present in peach-derived products, which are enriched in fresh-fruit-derived preparations (Peel and FPP) but are also present in PPP. The Syrup - which was the least enriched in antioxidants - displayed no protective effect in our experiments. These effects cumulated in decreased levels of transaminases and lactate dehydrogenase leakage into serum and maintenance of organ architecture. Therefore, the herein presented results show evidence that supplementation with peach products may be protective against organ damage caused by oxidative stress, being interesting candidates for production of antioxidant-enriched functional foods. (C) 2014 Elsevier Inc. All rights reserved.
C1 [Gasparotto, Juciano; Somensi, Nauana; Bortolin, Rafael Calixto; Girardi, Carolina Saibro; Kunzler, Alice; Rabelo, Thallita Kelly; Schnorr, Carlos Eduardo; Moresco, Karla Suzana; Zanotto-Filho, Alfeu; Moreira, Jose Claudio Fonseca; Gelain, Daniel Pens] Univ Fed Rio Grande do Sul, Inst Ciencias Micas Saude, Dept Bioquim, Centro Estudos Estresse Oxidativo, BR-90046900 Porto Alegre, RS, Brazil.
   [Vizzotto, Marcia; Raseira, Maria do Carmo Bassols] Empresa Brasileira Pesquisa Agropecudria, Embrapa Clima Temperado, Pelotas, RS, Brazil.
   [Bassani, Valquiria Linck; Yatsu, Francini Kiyono Jorge] Univ Fed Rio Grande do Sul, Fac Farm, Programa Pos Graduacao Ciencias Farmaceut, BR-90046900 Porto Alegre, RS, Brazil.
C3 Universidade Federal do Rio Grande do Sul; Empresa Brasileira de
   Pesquisa Agropecuaria (EMBRAPA); EMBRAPA Clima Temperado; Universidade
   Federal do Rio Grande do Sul
RP Gasparotto, J (corresponding author), Rua Ramiro Barcelos,2600-anexo, BR-90035003 Porto Alegre, RS, Brazil.
EM Juciano.gasparotto@gmail.com
RI Bortolin, Rafael/O-2711-2014; Girardi, Carolina/M-8804-2019; moreira,
   jose/AAO-6400-2021; Moresco, Karla Suzana/AFK-0651-2022; Schnorr,
   Carlos/AAA-3545-2021; Gelain, Daniel/I-5144-2013; Kunzler,
   Alice/S-4441-2016; ZANOTTO-FILHO, ALFEU/A-8172-2016; Rabelo, Thallita
   Kelly/J-8810-2016; Linck Bassani, Valquiria/K-4035-2019; Vizzotto,
   Marcia/F-3910-2015; Gasparotto, Juciano/K-3239-2013
OI ZANOTTO-FILHO, ALFEU/0000-0002-4188-3095; Moresco, Karla
   Suzana/0000-0002-0892-2830; Rabelo, Thallita Kelly/0000-0002-9047-8133;
   Saibro Girardi, Carolina/0000-0002-1685-011X; Calixto Bortolin,
   Rafael/0000-0003-4780-8499; Schnorr, Carlos Eduardo/0000-0002-2047-2107;
   Linck Bassani, Valquiria/0000-0001-9525-5855; Vizzotto,
   Marcia/0000-0002-8071-4980; Gasparotto, Juciano/0000-0003-2545-7288
FU FAPERGS [PqG 12099/8, PRONEX 1000274]; CAPES [PROCAD 066/2007]; CNPq;
   PROPESQ-UFRGS; Embrapa
FX Funding sources: FAPERGS (PqG 12099/8, PRONEX 1000274) CAPES (PROCAD
   066/2007), CNPq, PROPESQ-UFRGS and Embrapa.
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NR 69
TC 18
Z9 19
U1 0
U2 27
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0955-2863
EI 1873-4847
J9 J NUTR BIOCHEM
JI J. Nutr. Biochem.
PD DEC
PY 2014
VL 25
IS 12
BP 1282
EP 1295
DI 10.1016/j.jnutbio.2014.07.004
PG 14
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA AW2JF
UT WOS:000346113200006
PM 25287815
OA Green Published
DA 2025-06-11
ER

PT J
AU Ishimitsu, T
   Ohno, E
   Ueno, Y
   Onoda, S
   Nagase, A
   Ohira, T
   Nakano, N
   Satonaka, H
AF Ishimitsu, Toshihiko
   Ohno, Eri
   Ueno, Yasuhiko
   Onoda, Shou
   Nagase, Akihiko
   Ohira, Takehiro
   Nakano, Nobuyuki
   Satonaka, Hiroshi
TI Effects of atorvastatin and ezetimibe on endothelial function in
   dyslipidemic patients with chronic kidney disease
SO CLINICAL AND EXPERIMENTAL NEPHROLOGY
LA English
DT Article
DE Dyslipidemia; Lipid-lowering drug; Statin; Cholesterol transporter
   inhibitor; Endothelial function; Chronic kidney disease
ID METABOLIC SYNDROME; RENAL PROTECTION; DYSFUNCTION; SIMVASTATIN; THERAPY;
   INFLAMMATION; CHOLESTEROL; PROGRESSION; STATINS; EVENTS
AB Chronic kidney disease (CKD) is a staple risk factor not only for renal failure but also for cardiovascular diseases. In addition, because dyslipidemia facilitates atherosclerosis and renal dysfunction, antihyperlipidemic treatment is important to prevent cardiac and renal events in CKD patients.
   We compared the effects of a statin and an intestinal cholesterol transporter inhibitor in 20 dyslipidemic patients with CKD presenting with proteinuria and/or glomerular filtration rate < 60 mL/min/1.73 m(2). Either 5-10 mg atorvastatin or 10 mg ezetimibe was given for 3 months each in a randomized crossover manner and the parameters of oxidative stress, inflammation and endothelial function were compared.
   Atorvastatin lowered serum low-density lipoprotein (LDL) cholesterol more prominently than ezetimibe (103 +/- A 38 vs 130 +/- A 45 mg/dL, p < 0.001), while serum gamma-glutamyl transpeptidase was higher in atorvastatin than in ezetimibe (29 +/- A 16 vs 25 +/- A 11 U/L, p = 0.013). On the other hand, serum oxidized LDL and high-sensitivity C-reactive protein were lower in the atorvastatin treatment period than in the ezetimibe treatment period (109 +/- A 38 vs 146 +/- A 67 U/L, p = 0.002; 1.02 +/- A 1.46 vs 1.47 +/- A 1.77 A mu g/mL, p = 0.003). Although serum adiponectin was not significantly different between the two drugs, the reactive hyperemia index, an index of endothelial function, was higher in atorvastatin than in ezetimibe (1.94 +/- A 0.58 vs 1.60 +/- A 0.44, p = 0.023).
   It is concluded that atorvastatin is more potent than ezetimibe in improving the serum lipid profile, reducing oxidative stress, suppressing inflammation and preserving endothelial function, while ezetimibe may be advantageous in reducing the hepatic lipid load.
C1 [Ishimitsu, Toshihiko; Ohno, Eri; Ueno, Yasuhiko; Onoda, Shou; Nagase, Akihiko; Ohira, Takehiro; Nakano, Nobuyuki; Satonaka, Hiroshi] Dokkyo Med Univ, Dept Cardiol & Nephrol, Mibu, Tochigi 3210293, Japan.
C3 Dokkyo Medical University
RP Ishimitsu, T (corresponding author), Dokkyo Med Univ, Dept Cardiol & Nephrol, Mibu, Tochigi 3210293, Japan.
EM isimitu@dokkyomed.ac.jp
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NR 33
TC 12
Z9 13
U1 0
U2 7
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1342-1751
EI 1437-7799
J9 CLIN EXP NEPHROL
JI Clin. Exp. Nephrol.
PD OCT
PY 2014
VL 18
IS 5
BP 704
EP 710
DI 10.1007/s10157-013-0904-7
PG 7
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA AR6UT
UT WOS:000343719300004
PM 24198051
DA 2025-06-11
ER

PT J
AU Tabara, Y
   Igase, M
   Saito, I
   Nishida, W
   Kohara, K
   Sakurai, S
   Kawamura, R
   Okada, Y
   Hitsumoto, S
   Onuma, H
   Nagai, T
   Takata, Y
   Uetani, E
   Takita, R
   Kido, T
   Ochi, N
   Osawa, H
   Tanigawa, T
   Miki, T
AF Tabara, Yasuharu
   Igase, Michiya
   Saito, Isao
   Nishida, Wataru
   Kohara, Katsuhiko
   Sakurai, Susumu
   Kawamura, Ryoichi
   Okada, Yoko
   Hitsumoto, Shinichi
   Onuma, Hiroshi
   Nagai, Tokihisa
   Takata, Yasunori
   Uetani, Eri
   Takita, Rie
   Kido, Tomoko
   Ochi, Namiko
   Osawa, Haruhiko
   Tanigawa, Takeshi
   Miki, Tetsuro
TI Association of hematological parameters with insulin resistance, insulin
   sensitivity, and asymptomatic cerebrovascular damage: The J-SHIP and
   Toon Health Study
SO CLINICAL HEMORHEOLOGY AND MICROCIRCULATION
LA English
DT Article
DE Hematocrit; insulin resistance; atherosclerosis; cerebrovascular disease
ID INCIDENT CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; BLOOD-VISCOSITY;
   RISK-FACTORS; ANEMIA; POPULATION; HEART; HEMATOCRIT; MORTALITY;
   VARIABLES
AB BACKGROUND: Elevated hematocrit levels have been suggested to be an independent determinant of insulin resistance and type 2 diabetes. To clarify the diagnostic significance of hematocrit level, we investigated the association with hemodynamic profiles, insulin resistance and insulin sensitivity, arterial properties, and asymptomatic cerebrovascular damage in a general Japanese population.
   METHODS: This study included 1,978 participants from two independent cohorts. Insulin sensitivity was assessed by the oral 75 g glucose tolerance test. Carotid ultrasonography was performed to evaluate atherosclerosis and wall shear stress. Periventricular hyperintensity and lacunar infarction were assessed by brain magnetic resonance imaging.
   RESULTS: Hematocrit quartile showed a stepwise association with insulin sensitivity (Q1: 2.2 +/- 0.7, Q2: 2.0 +/- 0.7, Q3: 1.9 +/- 0.7, Q4: 1.8 +/- 0.6, p < 0.001) and insulin resistance (1.0 +/- 0.6, 1.2 +/- 0.7, 1.3 +/- 0.8, 1.5 +/- 1.0, p < 0.001). Multiple linear regression analysis adjusted for possible covariates identified hematocrit as an independent determinant of insulin sensitivity (beta = -0.074, p = 0.019) and insulin resistance (beta = 0.115, p < 0.001). However, this association was lost after further adjustment for visceral fat area and plasma alanine aminotransferase level. Further, no significant association was observed between hematocrit and carotid intima-media thickness (p = 0.306) where as wall shear stress was inversely associated with the carotid atherosclerosis (r = -0.250, p < 0.001). In contrast, a low hematocrit level was independently associated with periventricular hyperintensity (odds ratio 0.87 (95% CI 0.80-0.95), p = 0.001).
   CONCLUSION: Hematocrit was positively associated with insulin resistance and insulin sensitivity. This association was epiphenomenon of visceral and hepatic adiposity. Conversely, low hematocrit was a significant risk factor for periventricular hyperintensity independent of insulin resistance.
C1 [Tabara, Yasuharu] Kyoto Univ, Ctr Genom Med, Grad Sch Med, Kyoto 6068507, Japan.
   [Igase, Michiya; Kohara, Katsuhiko; Okada, Yoko; Nagai, Tokihisa; Uetani, Eri; Takita, Rie; Kido, Tomoko; Ochi, Namiko; Miki, Tetsuro] Ehime Univ, Dept Geriatr Med, Grad Sch Med, Toon City, Japan.
   [Nishida, Wataru; Kawamura, Ryoichi; Takata, Yasunori; Osawa, Haruhiko] Ehime Univ, Dept Mol & Genet Med, Grad Sch Med, Toon City, Japan.
   [Saito, Isao; Sakurai, Susumu; Onuma, Hiroshi; Tanigawa, Takeshi] Ehime Univ, Dept Publ Hlth, Grad Sch Med, Toon City, Japan.
   [Saito, Isao; Kohara, Katsuhiko; Onuma, Hiroshi; Osawa, Haruhiko; Tanigawa, Takeshi; Miki, Tetsuro] Ehime Univ, Proteomed Res Ctr, Div Antiaging & Genet, Toon City, Japan.
   [Hitsumoto, Shinichi] Ehime Univ Hosp, Med Welf Support Ctr, Toon, Japan.
   [Sakurai, Susumu] Tenri Hlth Care Univ, Fac Hlth Care, Dept Clin Lab Sci, Tenri, Nara, Japan.
C3 Kyoto University; Ehime University; Ehime University; Ehime University;
   Ehime University; Ehime University
RP Tabara, Y (corresponding author), Kyoto Univ, Ctr Genom Med, Grad Sch Med, Sakyo Ku, Shogoinkawaramachi 53, Kyoto 6068507, Japan.
EM tabara@genome.med.kyoto-u.ac.jp
FU Ministry of Education, Culture, Sports, Science and Technology of Japan;
   Japan Society for the Promotion of Science; Ministry of Health, Labour
   and Welfare of Japan; Science and Technology Incubation Program in
   Advanced Regions, Japan Science and Technology Agency; Japan
   Arteriosclerosis Prevention Fund; Grants-in-Aid for Scientific Research
   [23659382, 20390185, 23590796] Funding Source: KAKEN
FX We are grateful to all of the staff involved in the Toon Health Study.
   This work was supported by Grants-in-Aid for Scientific Research and
   Program for Enhancing Systematic Education in Graduate School from the
   Ministry of Education, Culture, Sports, Science and Technology of Japan;
   Program for Enhancing Systematic Education in Graduate School from the
   Japan Society for the Promotion of Science; the Ministry of Health,
   Labour and Welfare of Japan; the Science and Technology Incubation
   Program in Advanced Regions, Japan Science and Technology Agency; and
   the Japan Arteriosclerosis Prevention Fund.
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NR 38
TC 7
Z9 9
U1 0
U2 5
PU IOS PRESS
PI AMSTERDAM
PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS
SN 1386-0291
EI 1875-8622
J9 CLIN HEMORHEOL MICRO
JI Clin. Hemorheol. Microcirc.
PY 2013
VL 55
IS 3
BP 297
EP 311
DI 10.3233/CH-2012-1634
PG 15
WC Hematology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Hematology; Cardiovascular System & Cardiology
GA 279KN
UT WOS:000328959000002
PM 23109550
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Scholtens, AM
   Tio, RA
   Willemsen, A
   Dierckx, RAJO
   Boersma, HH
   Zeebregts, CJ
   Glaudemans, AWJM
   Slart, RHJA
AF Scholtens, A. M.
   Tio, R. A.
   Willemsen, A.
   Dierckx, R. A. J. O.
   Boersma, H. H.
   Zeebregts, C. J.
   Glaudemans, A. W. J. M.
   Slart, R. H. J. A.
TI Myocardial perfusion reserve compared with peripheral perfusion reserve:
   A [13N]ammonia PET study
SO JOURNAL OF NUCLEAR CARDIOLOGY
LA English
DT Article
DE Myocardial perfusion imaging; peripheral perfusion imaging; coronary
   flow reserve; vasodilator stress N-13 ammonia
ID IDIOPATHIC DILATED CARDIOMYOPATHY; CORONARY-ARTERY-DISEASE; BLOOD-FLOW
   RESERVE; ENDOTHELIAL FUNCTION; ADENOSINE; HEART; HETEROGENEITY;
   EXERCISE; HUMANS
AB [13N]ammonia PET allows quantification of myocardial perfusion. The similarity between peripheral flow and myocardial perfusion is unclear. We compared perfusion flow in the myocardium with the upper limb during rest and adenosine stress [13N]ammonia PET to establish whether peripheral perfusion reserve (PPR) correlates with MPR.
   [13N]ammonia myocardial perfusion PET-scans of 58 patients were evaluated (27 men, 31 women, age 64 +/- A 13 years) and were divided in four subgroups: patients with coronary artery disease (CAD, n = 15), cardiac syndrome X (SX, n = 14), idiopathic dilating cardiomyopathy (DCM, n = 16), and normal controls (NC, n = 13). Peripheral limb perfusion was measured in the muscular tissue of the proximal upper limb and quantified through a 2-tissue-compartment model and the PPR was calculated (stress/rest ratio). MPR was also calculated by a 2-tissue-compartment model. The PPR results were compared with the MPR findings.
   Mean myocardial perfusion increased significantly in all groups as evidenced by the MPR (CAD 1.99 +/- A 0.47; SX 1.39 +/- A 0.31; DCM 1.72 +/- A 0.69; NC 2.91 +/- A 0.78). Mean peripheral perfusion also increased but not significantly and accompanied with great variations within and between groups (mean PPR: CAD 1.30 +/- A 0.79; SX 1.36 +/- A 0.71; DCM 1.60 +/- A 1.22; NC 1.27 +/- A 0.63). The mean difference between PPR and MPR for all subpopulations varied widely. No significant correlations in flow reserve were found between peripheral and myocardial microcirculatory beds in any of the groups (Total group: r = -0.07, SEE = 0.70, CAD: r = 0.14, SEE = 0.48, SX: r = 0.17, SEE = 0.30, DCM: r = -0.11, SEE = 0.71, NC: r = -0.19, SEE = 0.80).
   No correlations between myocardial and peripheral perfusion (reserve) were found in different patient populations in the same PET session. This suggests a functional difference between peripheral and myocardial flow in the response to intravenously administered adenosine stress.
C1 [Scholtens, A. M.] Univ Med Ctr Utrecht, Dept Imaging, NL-3508 GA Utrecht, Netherlands.
   [Tio, R. A.] Univ Groningen, Univ Med Ctr Groningen, Dept Cardiol, Thoraxctr, NL-9713 AV Groningen, Netherlands.
   [Willemsen, A.; Dierckx, R. A. J. O.; Boersma, H. H.; Glaudemans, A. W. J. M.; Slart, R. H. J. A.] Univ Groningen, Univ Med Ctr Groningen, Dept Nucl Med & Mol Imaging, NL-9713 AV Groningen, Netherlands.
   [Boersma, H. H.] Univ Groningen, Univ Med Ctr Groningen, Dept Clin Pharm, NL-9713 AV Groningen, Netherlands.
   [Zeebregts, C. J.] Univ Groningen, Univ Med Ctr Groningen, Dept Surg, Div Vasc Surg, NL-9713 AV Groningen, Netherlands.
   [Tio, R. A.; Boersma, H. H.; Zeebregts, C. J.; Slart, R. H. J. A.] Univ Groningen, Univ Med Ctr Groningen, Cardiovasc Imaging Grp Groningen, NL-9713 AV Groningen, Netherlands.
C3 Utrecht University; Utrecht University Medical Center; University of
   Groningen; University of Groningen; University of Groningen; University
   of Groningen; University of Groningen
RP Scholtens, AM (corresponding author), Univ Med Ctr Utrecht, Dept Imaging, E01-132,POB 85500, NL-3508 GA Utrecht, Netherlands.
EM a.m.scholtens-2@umcutrecht.nl
RI Tio, Rene/ABG-2820-2020; Scholtens, Asbjørn/AAE-8007-2020
OI Scholtens, Asbjorn/0000-0003-3894-5010; Boersma,
   Hendrikus/0000-0003-1892-9830; Glaudemans, Andor/0000-0001-8081-0641
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NR 20
TC 13
Z9 13
U1 0
U2 1
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1071-3581
J9 J NUCL CARDIOL
JI J. Nucl. Cardiol.
PD APR
PY 2011
VL 18
IS 2
BP 238
EP 246
DI 10.1007/s12350-011-9339-2
PG 9
WC Cardiac & Cardiovascular Systems; Radiology, Nuclear Medicine & Medical
   Imaging
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Radiology, Nuclear Medicine &
   Medical Imaging
GA 744RF
UT WOS:000289111400007
PM 21347555
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Gateva, AT
   Velikova, TV
   Kamenov, ZA
AF Gateva, Antoaneta T.
   Velikova, Tsvetelina V.
   Kamenov, Zdravko A.
TI Peroxiredoxin 4 levels in patients with PCOS and/or obesity
SO JOURNAL OF GYNECOLOGY OBSTETRICS AND HUMAN REPRODUCTION
LA English
DT Article
DE PCOS; Peroxiredoxin; Cardiovascular risk
ID POLYCYSTIC-OVARY-SYNDROME; IMPAIRED GLUCOSE-TOLERANCE; OXIDATIVE STRESS;
   CARDIOVASCULAR RISK; WOMEN; PREVALENCE; OXYGEN
AB Background: Peroxiredoxin 4 is a part of endogen antioxidant system and its levels are elevated in increased oxidative stress conditions. It is found to be positively associated with cardiovascular risk. The aim of the study was to investigate peroxiredoxin 4 levels in women with polycystic ovarian syndrome (PCOS) and/or obesity.
   Methods: In this cros-sesctional study were included 80 patients. Anthropometric measurements and biochemical tests, including peroxiredoxin 4 measurement, were performed.
   Results: There was a tendency towards lower peroxiredoxin 4 levels in non-obese PCOS subjects (5674.8 +/- 3822.4 pg/ml), higher in obese PCOS (6588.9 +/- 3731.0 pg/ml) and even higher in obese patients without PCOS (7724.6 +/- 4840.4 pg/ml). Patients with abdominal obesity according to waist circumference and waist-to-hip ratio had significantly higher levels of peroxiredoxin compared to those without (7108.2 +/- 4568.0 vs. 5079.8 +/- 2555.4 pg/ml; p = 0.015 and 7310.6 +/- 2646.2 vs. 4785.0 +/- 2646.2 pg/ml; p = 0.013). There was no difference in peroxiredoxin 4 levels in patients with and without insulin resistance, hypertension, dislipidemia, hyperandrogenemia, metabolic syndrome. Peroxiredoxin 4 showed weak positive correlation to weight (r = 0.228; p = 0.044) and visceral adiposity index (r = 0.278; p = 0.031) and higher to erythrocyte sedimentation rate (r = 0.4; p < 0.01), but not to hormonal parameters and insulin sensitivity indexes.
   Conclusions: Non-obese patients with PCOS have a tendency towards lower peroxiredoxin 4 levels compared to obese patients with and without PCOS. Patients with abdominal obesity have significantly higher peroxiredoxin 4 levels than those without. We were not able to prove correlation between peroxiredoxin 4 levels and hormonal and carbohydrate status of the PCOS patients. (C) 2019 Elsevier Masson SAS. All rights reserved.
C1 [Gateva, Antoaneta T.; Kamenov, Zdravko A.] Med Univ Sofia, Univ Hosp Alexandrovska, Bulgaria Dept Internal Med, Clin Endocrinol, Sofia, Bulgaria.
   [Velikova, Tsvetelina V.] Univ Hosp Lozenetz, Dept Clin Immunol, Sofia, Bulgaria.
C3 Medical University Sofia; University of Sofia
RP Gateva, AT (corresponding author), Med Univ Sofia, Clin Endocrinol, Univ Hosp Alexandrovska, 1 Georgi Sofiiski Str, Sofia 1431, Bulgaria.
EM tony_gateva@yahoo.com
RI Gateva, Antoaneta/AGT-4861-2022; Velikova, Tsvetelina/H-6932-2019
OI Velikova, Tsvetelina/0000-0002-0593-1272
FU Medical University-Sofia, Bulgaria [529/21.01.2016, 69/27.05.2016]
FX The study was realized with the financial support of Medical
   University-Sofia, Bulgaria, Grant 2016, Project 529/21.01.2016, Contract
   69/27.05.2016. The funding source had no role in study design; in the
   collection, analysis and interpretation of data; in the writing of the
   report; and in the decision to submit the article for publication.
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NR 25
TC 7
Z9 7
U1 1
U2 3
PU ELSEVIER MASSON, CORP OFF
PI PARIS
PA 65 CAMILLE DESMOULINS CS50083 ISSY-LES-MOULINEAUX, 92442 PARIS, FRANCE
SN 2468-7847
EI 1773-0430
J9 J GYNECOL OBSTET HUM
JI J. Gynecol. Obstet. Hum. Reprod.
PD NOV
PY 2019
VL 48
IS 9
BP 739
EP 743
DI 10.1016/j.jogoh.2019.04.002
PG 5
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA JX5ZL
UT WOS:000503812600007
PM 30980996
DA 2025-06-11
ER

PT J
AU Schiffner, R
   Rodríguez-González, GL
   Rakers, F
   Nistor, M
   Nathanielsz, PW
   Daneva, T
   Schwab, M
   Lehmann, T
   Schmidt, M
AF Schiffner, Rene
   Rodriguez-Gonzalez, Guadalupe L.
   Rakers, Florian
   Nistor, Marius
   Nathanielsz, Peter W.
   Daneva, Teodora
   Schwab, Matthias
   Lehmann, Thomas
   Schmidt, Martin
TI Effects of Late Gestational Fetal Exposure to Dexamethasone
   Administration on the Postnatal Hypothalamus-Pituitary-Adrenal Axis
   Response to Hypoglycemia in Pigs
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE HPA axis; ACTH; cortisol; stress response; hypoglycemia
ID INSULIN-INDUCED HYPOGLYCEMIA; SYMPATHETIC-NERVOUS-SYSTEM; ENDOCRINE
   STRESS RESPONSE; RENAL GLUCOSE-PRODUCTION; ANTENATAL CORTICOSTEROIDS;
   ENERGY HOMEOSTASIS; SHEEP; GLUCOCORTICOIDS; CATECHOLAMINES; METAANALYSIS
AB Background: Prenatal glucocorticoid administration alters the activity of the fetal hypothalamic-pituitary-adrenocortical axis (HPAA), and correspondingly the adenocorticotropic hormone (ACTH) and cortisol levels after birth. The dosages required for these effects are critically discussed. Activation of the HPAA is related to metabolic syndrome and diabetes mellitus. Hypoglycemia is the classic side effect of antidiabetic treatment. We hypothesized that a low dosage of dexamethasone in late pregnancy alters the HPAA response to hypoglycemia in pigs. Methods: 12 pregnant sows were randomly assigned to two groups which received either a low-dose intramuscular injection (99th and 100th day of gestation) of dexamethasone (0.06 mu g/kg body weight) or vehicle. Three months after birth, 18 dexamethasone-treated anaesthetized offspring and 12 control offspring underwent a 75 min hypoglycemic clamp (blood glucose below 4 mmol/L) procedure. Heart rate (HR), blood pressure, ACTH and cortisol levels and body weight (at birth and after three months) were recorded. Results: Dexamethasone-treated animals exhibited significantly elevated ACTH (139.9 +/- 12.7 pg/mL) and cortisol (483.1 +/- 30.3 nmol/L) levels during hypoglycemia as compared to the control group (41.7 +/- 6.5 pg/mL and 257.9 +/- 26.7 nmol/L, respectively), as well as an elevated HR (205.5 +/- 5.7 bpm) and blood pressure (systolic: 128.6 +/- 1.5, diastolic: 85.7 +/- 0.7 mmHg) response as compared to the control group (153.2 +/- 4.5 bpm; systolic: 118.6 +/- 1.6, diastolic: 79.5 +/- 1.4 mmHg, respectively; p < 0.001). Conclusions: Low-dose prenatal administration of dexamethasone not only exerts effects on the HPAA (ACTH and cortisol concentration) and vital parameters (HR and diastolic blood pressure) under baseline conditions, but also on ACTH, HR and systolic blood pressure during hypoglycemia.
C1 [Schiffner, Rene; Rakers, Florian; Nistor, Marius; Schwab, Matthias] Friedrich Schiller Univ, Dept Neurol, Jena Univ Hosp, D-07747 Jena, Germany.
   [Schiffner, Rene] Friedrich Schiller Univ, Dept Orthopaed, Jena Univ Hosp, D-07747 Jena, Germany.
   [Rodriguez-Gonzalez, Guadalupe L.] Natl Inst Med Sci & Nutr, Reprod Biol, Mexico City 14000, DF, Mexico.
   [Nathanielsz, Peter W.] Univ Wyoming, Dept Anim Sci, Laramie, WY 82071 USA.
   [Daneva, Teodora] Bulgarian Acad Sci, Inst Biol & Immunol Reprod, Sofia 1113, Bulgaria.
   [Lehmann, Thomas] Friedrich Schiller Univ, Jena Univ Hosp, Inst Med Stat Comp Sci & Documentat Sci, D-07743 Jena, Germany.
   [Schmidt, Martin] Friedrich Schiller Univ, Jena Univ Hosp, Inst Biochem 2, D-07743 Jena, Germany.
C3 Friedrich Schiller University of Jena; Friedrich Schiller University of
   Jena; University of Wyoming; Bulgarian Academy of Sciences; Friedrich
   Schiller University of Jena; Friedrich Schiller University of Jena
RP Schiffner, R (corresponding author), Friedrich Schiller Univ, Dept Neurol, Jena Univ Hosp, D-07747 Jena, Germany.; Schiffner, R (corresponding author), Friedrich Schiller Univ, Dept Orthopaed, Jena Univ Hosp, D-07747 Jena, Germany.
EM rene.schiffner@med.uni-jena.de; letyrodgon@hotmail.com;
   Florian.Rakers@med.uni-jena.de; vorenus@web.de;
   Peter.Nathanielsz@uwyo.edu; danevadoki@abv.bg;
   Matthias.Schwab@med.uni-jena.de; Thomas.Lehmann@med.uni-jena.de;
   Martin.Schmidt@med.uni-jena.de
RI Rodríguez-González, Guadalupe/AAB-1291-2021; Rakers,
   Florian/KUD-3769-2024
OI Daneva, Teodora/0000-0003-1701-6984; Rodriguez Gonzalez, Guadalupe
   Leticia/0000-0002-3267-4793; Schiffner, Rene/0000-0001-9546-6273;
   Nathanielsz, Peter/0000-0001-8410-6280; Schmidt,
   Martin/0000-0003-3578-4338
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NR 40
TC 10
Z9 12
U1 0
U2 4
PU MDPI AG
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD NOV
PY 2017
VL 18
IS 11
AR 2241
DI 10.3390/ijms18112241
PG 11
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA FO4KK
UT WOS:000416811300015
PM 29077038
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Korybalska, K
   Luczak, J
   Swora-Cwynar, E
   Kanikowska, A
   Czepulis, N
   Kanikowska, D
   Skalisz, H
   Breborowicz, A
   Grzymislawski, M
   Witowski, J
AF Korybalska, K.
   Luczak, J.
   Swora-Cwynar, E.
   Kanikowska, A.
   Czepulis, N.
   Kanikowska, D.
   Skalisz, H.
   Breborowicz, A.
   Grzymislawski, M.
   Witowski, J.
TI WEIGHT LOSS-DEPENDENT AND-INDEPENDENT EFFECTS OF MODERATE CALORIE
   RESTRICTION ON ENDOTHELIAL CELL MARKERS IN OBESITY
SO JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
LA English
DT Article
DE endothelial cells; caloric restriction; obesity; endothelial
   dysfunction; nitric oxide; adiponectin; asymmetric dimethylarginine;
   tumor necrosis factor-alpha
ID NITRIC-OXIDE; METABOLIC SYNDROME; INSULIN-RESISTANCE; OVERWEIGHT ADULTS;
   OXIDATIVE STRESS; PLASMA LEPTIN; INFLAMMATION; EXERCISE; DIET;
   HYPERTENSION
AB Endothelial cell dysfunction in obesity can be reduced by calorie restriction (CR), however it is unclear whether this benefit requires a concomitant weight loss or is it simply related to the reduced calorie intake per se. In our study serum was drawn from 41 obese women who were undergoing an 8-week dietary intervention with 15 30% energy deficit, and from 48 age- and sex-matched controls of normal weight. Serum was analysed for biomarkers of endothelial cell function, oxidative stress and inflammation. Compared with non-obese individuals, the obese patients had lower serum levels of nitric oxide (NO), adiponectin, and decreased serum antioxidant status. They also had significantly higher levels of adhesive molecules, thrombomodulin (TM), von Wilebrand factor (vWF), asymmetric dimethylarginine (ADMA), tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and leptin. To further characterize the effect of moderate CR, the patients were ranked into two comparable groups according to the extent of weight loss- below and above the median (-5.8 kg). A moderate dietary intervention did not correct adiponectin, antioxidant status, vWF, TM, and plasminogen activator inhibitor-1 (PAI-1) but ameliorated changes in other parameters. Only changes in NO and to a lesser degree- in sE-selectin showed a clear relationship with the magnitude of weight reduction. By contrast, a beneficial reduction in TNF-alpha occurred equally in patients who lost more or less weight after caloric restriction. We concluded that moderate calorie restriction could still improve several parameters of endothelial cell function irrespective of whether it was accompanied by changes in body mass. However, a significant improvement in nitric oxide, a key mediator of endothelial well-being, requires a substantial reduction in body weight.
C1 [Korybalska, K.; Luczak, J.; Czepulis, N.; Kanikowska, D.; Breborowicz, A.; Witowski, J.] Poznan Univ Med Sci, Dept Pathophysiol, 8 Rokietnicka Str, PL-60806 Poznan, Poland.
   [Swora-Cwynar, E.; Kanikowska, A.; Grzymislawski, M.] Poznan Univ Med Sci, Dept Internal Med Metab Dis & Dietet, Poznan, Poland.
   [Skalisz, H.] Reg Blood Ctr & Blood Treatment, Poznan, Poland.
C3 Poznan University of Medical Sciences; Poznan University of Medical
   Sciences
RP Korybalska, K (corresponding author), Poznan Univ Med Sci, Dept Pathophysiol, 8 Rokietnicka Str, PL-60806 Poznan, Poland.
EM koryb@ump.edu.pl
RI Korybalska, Katarzyna/ABG-1654-2021; Kanikowska, Dominika/AAJ-9454-2020
OI Kanikowska, Dominika/0000-0001-8433-5745
FU Polish Ministry of Science and Higher Education [NCN-NN404 151340]
FX This work was supported by Grant NCN-NN404 151340 from the Polish
   Ministry of Science and Higher Education.
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NR 40
TC 21
Z9 22
U1 0
U2 3
PU POLISH PHYSIOLOGICAL SOC
PI GRZEGORZECKA
PA JAGIELLONIAN UNIV SCHOOL MED, INST PHYSIOLOGY, 31-531 KRAKOW, 16
   GRZEGORZECKA, POLAND
SN 0867-5910
J9 J PHYSIOL PHARMACOL
JI J. Physiol. Pharmacol.
PD AUG
PY 2017
VL 68
IS 4
BP 597
EP 608
PG 12
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA FP1DA
UT WOS:000417349900012
PM 29151077
DA 2025-06-11
ER

PT J
AU Abou-Samra, M
   Lecompte, S
   Schakman, O
   Noel, L
   Many, MC
   Gailly, P
   Brichard, SM
AF Abou-Samra, Michel
   Lecompte, Sophie
   Schakman, Olivier
   Noel, Laurence
   Many, Marie C.
   Gailly, Philippe
   Brichard, Sonia M.
TI Involvement of adiponectin in the pathogenesis of dystrophinopathy
SO SKELETAL MUSCLE
LA English
DT Article
DE Adiponectin; Mdx; Inflammation; Skeletal muscle; AMPK signaling;
   NF-kappa B; Utrophin
ID DUCHENNE MUSCULAR-DYSTROPHY; NECROSIS-FACTOR-ALPHA; SKELETAL-MUSCLE
   CELLS; EVANS BLUE-DYE; NF-KAPPA-B; MDX MICE; INSULIN-RESISTANCE;
   TRANSGENIC MICE; ADIPOSE-TISSUE; MOUSE MODEL
AB Background: The hormone adiponectin (ApN) is decreased in the metabolic syndrome, where it plays a key pathogenic role. ApN also exerts some anti-inflammatory effects on skeletal muscles in mice exposed to acute or chronic inflammation. Here, we investigate whether ApN could be sufficiently potent to counteract a severe degenerative muscle disease, with an inflammatory component such as Duchenne muscular dystrophy (DMD).
   Methods: Mdx mice (a DMD model caused by dystrophin mutation) were crossed with mice overexpressing ApN in order to generate mdx-ApN mice; only littermates were used. Different markers of inflammation/oxidative stress and components of signaling pathways were studied. Global force was assessed by in vivo functional tests, and muscle injury with Evans Blue Dye (EBD). Eventually, primary cultures of human myotubes were used.
   Results: Circulating ApN was markedly diminished in mdx mice. Replenishment of ApN strikingly reduced muscle inflammation, oxidative stress, and enhanced the expression of myogenic differentiation markers along with that of utrophin A (a dystrophin analog) in mdx-ApN mice. Accordingly, mdx-ApN mice exhibited higher global force and endurance as well as decreased muscle damage as quantified by curtailed extravasation of EBD in myofibers. These beneficial effects of ApN were recapitulated in human myotubes. ApN mediates its protection via the adiponectin receptor 1 (AdipoR1, the main ApN receptor in muscle) and the AMPK-SIRT1-PGC-1a signaling pathway, leading to downregulation of the nuclear factor kappa B (NF-kappa B) and inflammatory genes, together with upregulation of utrophin.
   Conclusions: Adiponectin proves to be an extremely powerful hormone capable of protecting the skeletal muscle against inflammation and injury, thereby offering novel therapeutic perspectives for dystrophinopathies.
C1 [Abou-Samra, Michel; Lecompte, Sophie; Noel, Laurence; Brichard, Sonia M.] Catholic Univ Louvain, Inst Expt & Clin Res, Endocrinol Diabet & Nutr Unit, Med Sect, B-1200 Brussels, Belgium.
   [Schakman, Olivier; Gailly, Philippe] Catholic Univ Louvain, Inst Neurosci, Cellular & Mol Unit, Med Sect, B-1200 Brussels, Belgium.
   [Many, Marie C.] Catholic Univ Louvain, Expt Morphol Unit, Inst Expt & Clin Res, Med Sect, B-1200 Brussels, Belgium.
C3 Universite Catholique Louvain; Universite Catholique Louvain; Universite
   Catholique Louvain
RP Brichard, SM (corresponding author), Catholic Univ Louvain, Inst Expt & Clin Res, Endocrinol Diabet & Nutr Unit, Med Sect, B-1200 Brussels, Belgium.
EM sonia.brichard@uclouvain.be
RI Brichard, Sonia/B-4597-2013
OI Gailly, Philippe/0000-0002-9259-3813; Lecompte,
   Sophie/0000-0002-8806-242X; ABOU-SAMRA, Michel/0000-0003-2312-7998
FU Belgian Telethon, French Association against Myopathies (AFM Telethon);
   Foundation of Scientific and Medical Research [1.5097.12, T.0212.13];
   General Division of Scientific Research [ARC 12 - 17/047]
FX This work was supported by grants from the Belgian Telethon, French
   Association against Myopathies (AFM Telethon), the Foundation of
   Scientific and Medical Research (1.5097.12 and T.0212.13), and the
   General Division of Scientific Research (ARC 12 - 17/047). We are
   grateful to Aurore Lafosse for providing the human muscle samples.
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   Yang XD, 2010, MOL CELL BIOL, V30, P2170, DOI 10.1128/MCB.01343-09
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NR 48
TC 46
Z9 47
U1 0
U2 12
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 2044-5040
J9 SKELET MUSCLE
JI Skeletal Muscle
PD AUG 7
PY 2015
VL 5
AR 25
DI 10.1186/s13395-015-0051-9
PG 17
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA CO4UX
UT WOS:000359157300001
PM 26257862
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Sauder, KA
   McCrea, CE
   Ulbrecht, JS
   Kris-Etherton, PM
   West, SG
AF Sauder, Katherine A.
   McCrea, Cindy E.
   Ulbrecht, Jan S.
   Kris-Etherton, Penny M.
   West, Sheila G.
TI Pistachio Nut Consumption Modifies Systemic Hemodynamics, Increases
   Heart Rate Variability, and Reduces Ambulatory Blood Pressure in
   Well-Controlled Type 2 Diabetes: a Randomized Trial
SO JOURNAL OF THE AMERICAN HEART ASSOCIATION
LA English
DT Article
DE blood pressure; heart rate variability; hemodynamics; nutrition; type 2
   diabetes mellitus
ID CARDIAC AUTONOMIC FUNCTION; ATHEROSCLEROSIS RISK; METABOLIC SYNDROME;
   GLUCOSE CONTROL; HYPERTENSION; DISEASE; ADULTS; DIET; US; METAANALYSIS
AB Background-Managing cardiovascular risk factors is important for reducing vascular complications in type 2 diabetes, even in individuals who have achieved glycemic control. Nut consumption is associated with reduced cardiovascular risk; however, there is mixed evidence about the effect of nuts on blood pressure (BP), and limited research on the underlying hemodynamics. This study assessed the effect of pistachio consumption on BP, systemic hemodynamics, and heart rate variability in adults with well-controlled type 2 diabetes.
   Methods and Results-We enrolled 30 adults (40 to 74 years) with type 2 diabetes in a randomized, crossover, controlled feeding study. After a 2-week run-in period, participants consumed a low-fat control diet (27% fat) containing low-fat/high-carbohydrate snacks and a moderate-fat diet (33% fat) containing pistachios (20% of total energy) for 4 weeks each, separated by a 2-week washout. Following each diet period, we assessed BP, systemic hemodynamics, and heart rate variability at rest and during acute mental stress, and, in a subset of participants (n=21), 24-hour ambulatory BP. BP at rest and during stress did not differ between treatments. The pistachio diet significantly reduced total peripheral resistance (-3.7 +/- 2.9%, P=0.004), increased cardiac output (3.1 +/- 2.3%, P=0.002), and improved some measures of heart rate variability (all P<0.05). Systolic ambulatory BP was significantly reduced by 3.5 +/- 2.2 mm Hg (P=0.046) following the pistachio diet, with the greatest reduction observed during sleep (-5.7 +/- 2.6 mm Hg, P=0.052).
   Conclusions-A moderate-fat diet containing pistachios modestly improves some cardiovascular risk factors in adults with well-controlled type 2 diabetes.
C1 [Sauder, Katherine A.; McCrea, Cindy E.; Ulbrecht, Jan S.; West, Sheila G.] Penn State Univ, Dept Biobehav Hlth, University Pk, PA 16802 USA.
   [Kris-Etherton, Penny M.; West, Sheila G.] Penn State Univ, Dept Nutr Sci, University Pk, PA 16802 USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE);
   Pennsylvania State University; Pennsylvania State University -
   University Park; Penn State Behrend; Pennsylvania Commonwealth System of
   Higher Education (PCSHE); Pennsylvania State University; Pennsylvania
   State University - University Park; Penn State Behrend
RP West, SG (corresponding author), Penn State Univ, Dept Biobehav Hlth, 219 Biobehav Hlth Bldg, University Pk, PA 16802 USA.
EM sgw2@psu.edu
OI Kris-Etherton, Penny/0000-0001-6012-4900; West,
   Sheila/0000-0003-3488-8768; Sauder, Katherine/0000-0002-8473-8015
FU American Pistachio Growers (Fresno, CA); NIH [UL1RR033184/UL1TR000127,
   F31AG043224]
FX The study was supported primarily by the American Pistachio Growers
   (Fresno, CA), and, in part, by grants UL1RR033184/UL1TR000127 (PSU) and
   F31AG043224 (Sauder) from the NIH.
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NR 37
TC 40
Z9 43
U1 0
U2 18
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2047-9980
J9 J AM HEART ASSOC
JI J. Am. Heart Assoc.
PD AUG
PY 2014
VL 3
IS 4
AR e000873
DI 10.1161/JAHA.114.000873
PG 9
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA AO4HD
UT WOS:000341296600015
PM 24980134
OA Green Submitted, gold, Green Accepted, Green Published
DA 2025-06-11
ER

PT J
AU Aroor, AR
   Sowers, JR
   Bender, SB
   Nistala, R
   Garro, M
   Mugerfeld, I
   Hayden, MR
   Johnson, MS
   Salam, M
   Whaley-Connell, A
   DeMarco, VG
AF Aroor, Annayya R.
   Sowers, James R.
   Bender, Shawn B.
   Nistala, Ravi
   Garro, Mona
   Mugerfeld, Irina
   Hayden, Melvin R.
   Johnson, Megan S.
   Salam, Muhammad
   Whaley-Connell, Adam
   DeMarco, Vincent G.
TI Dipeptidylpeptidase Inhibition Is Associated with Improvement in Blood
   Pressure and Diastolic Function in Insulin-Resistant Male Zucker Obese
   Rats
SO ENDOCRINOLOGY
LA English
DT Article
ID LEFT-VENTRICULAR DYSFUNCTION; GLUCAGON-LIKE PEPTIDE-1; ENDOTHELIAL
   GROWTH-FACTOR; TYPE-2 DIABETES-MELLITUS; FATTY-ACID OXIDATION;
   CARDIAC-FUNCTION; HEART-FAILURE; CONTRACTILE DYSFUNCTION; PEPTIDASE-4
   INHIBITOR; METABOLIC SYNDROME
AB Diastolic dysfunction is a prognosticator for future cardiovascular events that demonstrates a strong correlation with obesity. Pharmacological inhibition of dipeptidylpeptidase-4 (DPP-4) to increase the bioavailability of glucagon-like peptide-1 is an emerging therapy for control of glycemia in type 2 diabetes patients. Accumulating evidence suggests that glucagon-like peptide-1 has insulin-independent actions in cardiovascular tissue. However, it is not known whether DPP-4 inhibition improves obesity-related diastolic dysfunction. Eight-week-old Zucker obese (ZO) and Zucker lean rats were fed normal chow diet or diet containing the DPP-4 inhibitor, linagliptin (LGT), for 8 weeks. Plasma DPP-4 activity was 3.3-fold higher in ZO compared with Zucker lean rats and was reduced by 95% with LGT treatment. LGT improved echocardiographic and pressure volume-derived indices of diastolic function that were impaired in ZO control rats, without altering food intake or body weight gain during the study period. LGT also blunted elevated blood pressure progression in ZO rats involving improved skeletal muscle arteriolar function, without reducing left ventricular hypertrophy, fibrosis, or oxidative stress in ZO hearts. Expression of phosphorylated-endothelial nitric oxide synthase (eNOS)(Ser1177), total eNOS, and sarcoplasmic reticulum calcium ATPase 2a protein was elevated in the LGT-treated ZO heart, suggesting improved Ca2+ handling. The ZO myocardium had an abnormal mitochondrial sarcomeric arrangement and cristae structure that were normalized by LGT. These studies suggest that LGT reduces blood pressure and improves intracellular Ca-i(2+) mishandling and cardiomyocyte ultrastructure, which collectively result in improvements in diastolic function in the absence of reductions in left ventricular hypertrophy, fibrosis, or oxidative stress in insulin-resistant ZO rats.
C1 [Aroor, Annayya R.; Sowers, James R.; Bender, Shawn B.; Nistala, Ravi; Garro, Mona; Mugerfeld, Irina; Hayden, Melvin R.; Johnson, Megan S.; Salam, Muhammad; Whaley-Connell, Adam; DeMarco, Vincent G.] Univ Missouri, Sch Med, Dept Internal Med, Columbia, MO 65212 USA.
   [Sowers, James R.; DeMarco, Vincent G.] Univ Missouri, Sch Med, Dept Med Pharmacol & Physiol, Columbia, MO 65212 USA.
   [Aroor, Annayya R.; Sowers, James R.; Bender, Shawn B.; Nistala, Ravi; Garro, Mona; Mugerfeld, Irina; Hayden, Melvin R.; Johnson, Megan S.; Salam, Muhammad; Whaley-Connell, Adam; DeMarco, Vincent G.] Univ Missouri, Diabet & Cardiovasc Ctr, Columbia, MO 65212 USA.
   [Aroor, Annayya R.; Sowers, James R.; Bender, Shawn B.; Nistala, Ravi; Garro, Mona; Mugerfeld, Irina; Hayden, Melvin R.; Johnson, Megan S.; Salam, Muhammad; Whaley-Connell, Adam] Harry S Truman Mem Vet Hosp, Columbia, MO 65212 USA.
C3 University of Missouri System; University of Missouri Columbia;
   University of Missouri System; University of Missouri Columbia;
   University of Missouri System; University of Missouri Columbia; US
   Department of Veterans Affairs; Veterans Health Administration (VHA);
   Harry S. Truman Memorial Veterans' Hospital
RP DeMarco, VG (corresponding author), Univ Missouri, Sch Med, Dept Internal Med, Div Endocrinol & Metab, 1 Hosp Dr, Columbia, MO 65212 USA.
EM demarcov@missouri.edu
RI salam, muhammad/KIB-9747-2024
OI Whaley-Connell, Adam/0000-0001-8955-5560; DeMarco,
   Vincent/0000-0003-2092-9995
FU Boehringer Ingelheim Pharma; National Institutes of Health
   [RO1-HL073101, RO1-HL107910]; Veterans Affairs Merit System Grant
   [0018]; Department of Veterans Affairs [CDA-2BB47]
FX This work was supported by Boehringer Ingelheim Pharma (V.G.D.).
   Additional support was provided by National Institutes of Health Grants
   RO1-HL073101 and RO1-HL107910 (to J.R.S.), the Veterans Affairs Merit
   System Grant 0018 (to J.R.S.), and the Department of Veterans Affairs
   Grant CDA-2BB47 (to A.W.C.).
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NR 65
TC 91
Z9 93
U1 1
U2 4
PU ENDOCRINE SOC
PI CHEVY CHASE
PA 8401 CONNECTICUT AVE, SUITE 900, CHEVY CHASE, MD 20815-5817 USA
SN 0013-7227
J9 ENDOCRINOLOGY
JI Endocrinology
PD JUL
PY 2013
VL 154
IS 7
BP 2501
EP 2513
DI 10.1210/en.2013-1096
PG 13
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 169EL
UT WOS:000320760700027
PM 23653460
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Othman, EM
   Kreissl, MC
   Kaiser, FR
   Arias-Loza, PA
   Stopper, H
AF Othman, Eman Maher
   Kreissl, Michael C.
   Kaiser, Franz R.
   Arias-Loza, Paula-Anahi
   Stopper, Helga
TI Insulin-Mediated Oxidative Stress and DNA Damage in LLC-PK1 Pig Kidney
   Cell Line, Female Rat Primary Kidney Cells, and Male ZDF Rat Kidneys In
   Vivo
SO ENDOCRINOLOGY
LA English
DT Article
ID GROWTH-FACTOR-I; 7,12-DIMETHYLBENZ(A)ANTHRACENE-INDUCED
   MAMMARY-CARCINOMA; HYDROGEN-PEROXIDE; SIGNAL-TRANSDUCTION; METABOLIC
   SYNDROME; BREAST-CANCER; HYPERINSULINEMIA; ACTIVATION; GENERATION;
   RECEPTOR
AB Hyperinsulinemia, a condition with excessively high insulin blood levels, is related to an increased cancer incidence. Diabetes mellitus is the most common of several diseases accompanied by hyperinsulinemia. Because an elevated kidney cancer risk was reported for diabetic patients, we investigated the induction of genomic damage by insulin in LLC-PK1 pig kidney cells, rat primary kidney cells, and ZDF rat kidneys. Insulin at a concentration of 5nM caused a significant increase in DNA damage in vitro. This was associated with the formation of reactive oxygen species (ROS). In the presence of antioxidants, blockers of the insulin, and IGF-I receptors, and a phosphatidylinositol 3-kinase inhibitor, the insulin-mediated DNA damage was reduced. Phosphorylation of protein kinase B (PKB or AKT) was increased and p53 accumulated. Inhibition of the mitochondrial and nicotinamide adenine dinucleotide phosphatase oxidase-related ROS production reduced the insulin-mediated damage. In primary rat cells, insulin also induced genomic damage. In kidneys from healthy, lean ZDF rats, which were infused with insulin to yield normal or high blood insulin levels, while keeping blood glucose levels constant, the amounts of ROS and the tumor protein (p53) were elevated in the high-insulin group compared with the control level group. ROS and p53 were also elevated in diabetic obese ZDF rats. Overall, insulin-induced oxidative stress resulted in genomic damage. If the same mechanisms are active in patients, hyperinsulinemia might cause genomic damage through the induction of ROS contributing to the increased cancer risk, against which the use of antioxidants and/or ROS production inhibitors might exert protective effects. (Endocrinology 154: 1434-1443, 2013)
C1 [Othman, Eman Maher; Stopper, Helga] Univ Wurzburg, Inst Pharmacol & Toxicol, D-97078 Wurzburg, Germany.
   [Othman, Eman Maher] Univ El Minia, Fac Pharm, Dept Analyt Chem, El Minia 61519, Egypt.
   [Kreissl, Michael C.; Kaiser, Franz R.] Univ Wurzburg, Dept Nucl Med, Univ Hosp Wurzburg, D-97080 Wurzburg, Germany.
   [Arias-Loza, Paula-Anahi] Univ Wurzburg, Dept Internal Med 1, D-97080 Wurzburg, Germany.
C3 University of Wurzburg; Egyptian Knowledge Bank (EKB); Minia University;
   University of Wurzburg; University of Wurzburg
RP Stopper, H (corresponding author), Univ Wurzburg, Dept Toxicol, Versbacher Str 9, D-97078 Wurzburg, Germany.
EM stopper@toxi.uni-wuerzburg.de
RI Othman, Eman/LBI-5240-2024; Kreissl, Michael Christoph/GRR-9938-2022
OI Kreissl, Michael Christoph/0000-0001-5905-6015; Arias-Loza,
   Anahi-Paula/0000-0003-4048-4719; Othman, Eman M./0000-0003-4781-9745
FU El-Minia University, Egypt; Deutscher Akademischer Austauschdienst
   Doktoranden Program; Interdisciplinary Center for Clinical Research
   "Interdisziplinares Zentrum fur Klinische Forschung" Wurzburg Grant
   [Z-2/21]; Comprehension Heart Failure Center Wurzburg
FX This work was supported by a scholarship from El-Minia University,
   Egypt, and by Deutscher Akademischer Austauschdienst Doktoranden Program
   (E.M.O.) and by the Interdisciplinary Center for Clinical Research
   "Interdisziplinares Zentrum fur Klinische Forschung" Wurzburg Grant
   Z-2/21 and the Comprehension Heart Failure Center Wurzburg (M.C.K. and
   P-A.A.-L.).
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NR 54
TC 22
Z9 25
U1 0
U2 6
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0013-7227
EI 1945-7170
J9 ENDOCRINOLOGY
JI Endocrinology
PD APR
PY 2013
VL 154
IS 4
BP 1434
EP 1443
DI 10.1210/en.2012-1768
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 112PX
UT WOS:000316605700007
PM 23456362
OA Bronze
DA 2025-06-11
ER

PT J
AU Alsultan, AI
   Seif, MA
   Amin, TT
   Naboli, M
   Alsuliman, AM
AF Alsultan, A. I.
   Seif, M. A.
   Amin, T. T.
   Naboli, M.
   Alsuliman, A. M.
TI Relationship between oxidative stress, ferritin and insulin resistance
   in sickle cell disease
SO EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
LA English
DT Article
DE Sickle cell; Ferritin; Antioxidants; Insulin resistance
ID RED-BLOOD-CELLS; SERUM FERRITIN; GLUTATHIONE-PEROXIDASE;
   SKELETAL-MUSCLE; SUPEROXIDE-DISMUTASE; METABOLIC SYNDROME; REACTIVE
   OXYGEN; PLASMA-GLUCOSE; STEADY-STATE; IRON STORES
AB Background: Sickle cell disease (SCD) is a hereditary hemoglobinopathy characterized by hemolytic anemia. The oxidative phenomena play a significant role in its pathophysiology. Blood transfusions are a therapeutic mainstay in SCD and repeated transfusions can result in iron overload. There is little direct information available to confirm the correlation between the oxidative stress, iron overload and insulin resistance in SCD patients.
   Objective: To investigate the relationship between iron overload, the disorders of antioxidants and insulin levels in blood of SCD patients and their matched controls.
   Methods: The antioxidant activities of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px), as well as the malondialdehyde (MDA, the membrane lipid peroxidation products) and carbonyl contents (the oxidative products of proteins) were estimated spectrophotometrically in erythrocytes of patients and control subjects of matched sex and ages. In addition, fasting blood glucose (FBG), ferritin and insulin levels were estimated in the sera of the same subjects.
   Results: The mean activity values of SOD, CAT and GSH-Px were significantly decreased, whereas the average values of MDA and carbonyl contents were significantly increased in erythrocytes of SCD patients in comparison to the corresponding values of the control subjects. The average levels of FBS, ferritin, insulin and homeostasis model assessment of insulin resistance (HOMA-IR) were significantly elevated in the sera of SCD patients as compared to the controls. In addition, both serum ferritin, and oxidative products (expressed as MDA and carbonyl levels) were significantly correlated with blood glucose, insulin level, and HOMA-IR.
   Conclusion: These findings may explain the role of elevated ferritin and oxidative products (i.e. MDA & carbonyl contents) in the development of insulin resistance and high glucose levels in SCD patients.
C1 [Seif, M. A.] King Fiasal Univ, Div Biochem, Dept Biomed Sci, King Fahd Hosp,Coll Med Al Ahsa, Al Hasa, Saudi Arabia.
   [Alsultan, A. I.; Naboli, M.] King Fiasal Univ, Div Endocrinol, Dept Internal Med, King Fahd Hosp,Coll Med Al Ahsa, Al Hasa, Saudi Arabia.
   [Amin, T. T.] King Fiasal Univ, Dept Family & Community Med, King Fahd Hosp,Coll Med Al Ahsa, Al Hasa, Saudi Arabia.
C3 King Faisal University; King Faisal University; King Faisal University
RP Seif, MA (corresponding author), King Fiasal Univ, Div Biochem, Dept Biomed Sci, King Fahd Hosp,Coll Med Al Ahsa, Al Hasa, Saudi Arabia.
RI Amin, Tarek Tawfik/E-6189-2012
OI Amin, Tarek Tawfik/0000-0003-2502-110X
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NR 54
TC 30
Z9 37
U1 0
U2 3
PU VERDUCI PUBLISHER
PI ROME
PA VIA GREGORIO VII, ROME, 186-00165, ITALY
SN 1128-3602
J9 EUR REV MED PHARMACO
JI Eur. Rev. Med. Pharmacol. Sci.
PD JUN
PY 2010
VL 14
IS 6
BP 527
EP 538
PG 12
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 633CK
UT WOS:000280476900005
PM 20712260
DA 2025-06-11
ER

PT J
AU Stanhewicz, AE
   Schlarmann, RL
   Brustkern, KM
   Jalal, DI
AF Stanhewicz, Anna E.
   Schlarmann, Rowan L.
   Brustkern, Kaila M.
   Jalal, Diana I.
TI Oxidative stress contributes to reductions in microvascular endothelial-
   and nitric oxide-dependent dilation in women with a history of
   gestational diabetes
SO JOURNAL OF APPLIED PHYSIOLOGY
LA English
DT Article
DE endothelial dysfunction; gestational diabetes; microvasculature; nitric
   oxide
ID FLOW-MEDIATED DILATION; CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME;
   CUTANEOUS VASODILATION; SUPEROXIDE-DISMUTASE; INSULIN-RESISTANCE;
   PREGNANT-WOMEN; INCREASED RISK; DYSFUNCTION; MELLITUS
AB Women with a history of gestational diabetes mellitus (GDM) are twice as likely to develop cardiovascular disease (CVD) and similar to 7 times as likely to develop type 2 diabetes as their age-matched counterparts. However, the mechanism(s) mediating these associations remain unclear. We hypothesized that endothelium- and (nitric oxide) NO-dependent dilation would be attenuated through oxidant stress mechanisms in the microvasculature of women with a history of GDM compared with control women with a history of uncomplicated pregnancy (HC). Ten HC (35 +/- 4 yr) and 10 GDM (34 +/- 4 yr) underwent a standard local heating protocol (42 degrees C; 0.1 degrees C.s(-1)). Two intradermal microdialysis fibers were placed in the ventral forearm for local delivery of lactated Ringer's (control) or 5 mM L-ascorbate. After full expression of the local heating response, 15 mM N-G-nitro-L-arginine methyl ester (NO synthase inhibition) was perfused. Red cell flux was measured continuously by laser-Doppler flowmetry, and cutaneous vascular conductance (CVC = flux/MAP) was standardized to maximum (% CVCmax; 28 mM SNP thorn 43 degrees C). Urine albumin:creatinine ratio (ACR) was measured. GDM had attenuated endothelium-dependent (GDM: 67 +/- 7 vs. HC: 90 +/- 4% CVCmax; P < 0.001) and NO-dependent (GDM: 54 +/- 7 vs. HC: 71 +/- 3% CVCmax; P = 0.001) dilation at the control site and tended to have higher urine ACR (P = 0.06). Both endothelium-dependent (R-2 = 0.53, P = 0.02) and NO-dependent (R-2 = 0.56, P = 0.01) dilation were related to urine ACR in GDM. L-ascorbate perfusion improved endothelium-dependent (82 +/- 5% CVCmax; P = 0.03 vs. control) and NO-dependent (68 +/- 5% CVCmax; P = 0.02 vs. control) dilation in GDM but had no effect in HC (P > 0.05). Otherwise healthy women with a history of GDM have attenuated microvascular endothelial function and this dysfunction is mediated, in part, by oxidative stress.
   NEW & NOTEWORTHY Women who have gestational diabetes during pregnancy are at greater risk for cardiovascular disease and type 2 diabetes in the decade following pregnancy. However, the mechanisms mediating this increased risk are unclear. Herein, we demonstrate that microvascular dysfunction, mediated by increase in oxidative stress, persists after pregnancy in women who had gestational diabetes, despite the remission of glucose tolerance.
C1 [Stanhewicz, Anna E.; Schlarmann, Rowan L.; Brustkern, Kaila M.] Univ Iowa, Dept Hlth & Human Physiol, Iowa City, IA 52242 USA.
   [Jalal, Diana I.] Iowa City Vet Affairs Hlth Care Syst, Iowa City, IA USA.
   [Jalal, Diana I.] Carver Coll Med, Dept Internal Med, Iowa City, IA USA.
C3 University of Iowa; US Department of Veterans Affairs; Veterans Health
   Administration (VHA); Iowa City VA Health Care System
RP Stanhewicz, AE (corresponding author), Univ Iowa, Dept Hlth & Human Physiol, Iowa City, IA 52242 USA.
EM anna-stanhewicz@uiowa.edu
RI Stanhewicz, Anna/KTI-4400-2024
OI Jalal, Diana/0000-0002-1975-8650
FU University of Iowa Fraternal Order of Eagles Diabetes Research Center;
   National Center for Advancing Translational Sciences [UL1TR002537];
   National Center for Advancing Translational Sciences [UL1TR002537]
   Funding Source: NIH RePORTER
FX This project was supported by a Pilot and Feasibility Grant from the
   University of Iowa Fraternal Order of Eagles Diabetes Research Center
   (to. A. E. Stanhewicz) and National Center for Advancing Translational
   Sciences Grant UL1TR002537 (University of Iowa Institute for Clinical
   and Translational Science).
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NR 76
TC 6
Z9 7
U1 0
U2 3
PU AMER PHYSIOLOGICAL SOC
PI Rockville
PA 6120 Executive Blvd, Suite 600, Rockville, MD, UNITED STATES
SN 8750-7587
EI 1522-1601
J9 J APPL PHYSIOL
JI J. Appl. Physiol.
PD AUG
PY 2022
VL 133
IS 2
BP 361
EP 370
DI 10.1152/japplphysiol.00189.2022
PG 10
WC Physiology; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology; Sport Sciences
GA 6W8OQ
UT WOS:000895986400011
PM 35796611
OA Green Published
DA 2025-06-11
ER

PT J
AU O'Toole, T
   Armitage, CJ
   van Tongeren, M
   Dienes, KA
AF O'Toole, Thomas
   Armitage, Christopher J.
   van Tongeren, Martie
   Dienes, Kimberly A.
TI Primary and secondary allostatic processes in the context of high-stress
   work: A multigroup moderation from the English longitudinal study of
   ageing
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE Allostatic Load; Allostasis; Hair Cortisol; Cohort Study; Effort-Reward
   Imbalance
ID EFFORT-REWARD IMBALANCE; HAIR CORTISOL; HEALTH; LOAD; POPULATION; MODEL
AB Evidence suggests that chronic cortisol excess may precede the development of an allostatic load, and that this association maybe influenced by the level of work stress. This study aims to investigate the associations between hair cortisol concentration and the development of systemic allostatic load cross-sectionally and at a lag of four years, stratified by level of effort-reward imbalance. The sample consisted of respondents from the English Longitudinal Study of Ageing (ELSA) who were in employment with hair cortisol measurements at baseline (wave 6), and allostatic load markers at baseline and follow-up (wave 8; n=411; 64% female). Hair cortisol was used as a measure of total cortisol expression over the preceding two months. Allostatic load was modelled as a count-based index using nine markers; three per system, across the immune, metabolic and cardiovascular systems. This model was then grouped by a median-cut effort reward-imbalance scale (0.83) and regression pathways were compared between groups using a series of ChiSquared tests of difference. Results provide evidence that higher hair cortisol concentrations predict an increase in immune and cardiovascular allostatic load cross-sectionally, and a metabolic allostatic load at a lag of four years. These pathways were found in the high effort-reward imbalance group, but not in the low effort-reward imbalance group. There were also significant differences found between groups for hair cortisol concentration as a predictor of concurrent immune and cardiovascular allostatic load Findings may indicate a novel temporality to the accumulation of an allostatic load, and that the "tipping point" between allostasis and allostatic load may lie within the ability of the HPA axis to regulate the cardiovascular system concurrently, with longitudinal consequences for metabolic syndrome indicators.
C1 [O'Toole, Thomas; van Tongeren, Martie] Univ Manchester, Sch Hlth Sci, Hlth Serv Res & Primary Care, Div Populat Hlth, Manchester, England.
   [Armitage, Christopher J.] Univ Manchester, Sch Hlth Sci, Div Psychol & Mental Hlth, Manchester, England.
   [Armitage, Christopher J.] NIHR Greater Manchester Patient Safety Res Collabo, Manchester, England.
   [Dienes, Kimberly A.] Swansea Univ, Sch Human & Hlth Sci, Dept Psychol, Swansea, Wales.
C3 University of Manchester; University of Manchester; Swansea University
RP O'Toole, T (corresponding author), Univ Manchester, Sch Hlth Sci, Hlth Serv Res & Primary Care, Div Populat Hlth, Manchester, England.
EM thomas.otoole@manchester.ac.uk; chris.armitage@manchester.ac.uk;
   martie.j.van-tongeren@manchester.ac.uk; k.a.dienes@swansea.ac.uk
OI Armitage, Christopher/0000-0003-2365-1765; Dienes,
   Kimberly/0000-0002-6119-7025; O'Toole, Thomas/0000-0001-9830-4229; van
   Tongeren, Martie/0000-0002-1205-1898
FU National Institute for Health and Care Research (NIHR) Manchester
   Biomedical Research Centre (BRC) [NIHR203308]; NIHR Greater Manchester
   Patient Safety Research Collaboration
FX This study has been delivered through the National Institute for Health
   and Care Research (NIHR) Manchester Biomedical Research Centre (BRC)
   (NIHR203308) and the NIHR Greater Manchester Patient Safety Research
   Collaboration. The views expressed are those of the author (s) and not
   necessarily those of the, the NIHR or the Department of Health and
   Social Care.
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NR 37
TC 0
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U2 0
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
EI 1873-3360
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD JAN
PY 2025
VL 171
AR 107193
DI 10.1016/j.psyneuen.2024.107193
EA OCT 2024
PG 9
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA K5V2P
UT WOS:001344542300001
PM 39461259
OA hybrid
DA 2025-06-11
ER

PT J
AU Preeti, K
   Fernandes, V
   Sood, A
   Khan, I
   Khatri, DK
   Singh, SB
AF Preeti, Kumari
   Fernandes, Valencia
   Sood, Anika
   Khan, Islauddin
   Khatri, Dharmendra Kumar
   Singh, Shashi Bala
TI Necrostatin-1S mitigates type-2 diabetes-associated cognitive decrement
   and lipotoxicity-induced neuro-microglia changes through
   p-RIPK-RIPK3-p-MLKL axis
SO METABOLIC BRAIN DISEASE
LA English
DT Article
DE Hyperlipidemia; Hyperglycemia; Hippocampus; Interleukin; Synapse;
   Microglia; Oligomer; Necrosome; Mitochondria
ID MIXED LINEAGE KINASE; DOMAIN-LIKE PROTEIN; CELL-DEATH; ACTIVATION; MICE;
   NECROPTOSIS; IMPAIRMENT; PALMITATE; OBESITY; STRESS
AB Type-2 diabetes mellitus (T2DM) is associated with neuroinflammation and cognitive decrement. Necroptosis programmed necrosis is emerging as the major contributing factor to central changes. It is best characterized by the upregulation of p-RIPK(Receptor Interacting Kinase), p-RIPK3, and the phosphorylated-MLKL (mixed-lineage kinase domain-like protein). The present study aims to evaluate the neuroprotective effect of Necrostatin (Nec-1S), a p-RIPK inhibitor, on cognitive changes in the experimental T2DM model in C57BL/6 mice and lipotoxicity-induced neuro-microglia changes in neuro2A and BV2 cells. Further, the study also explores whether Nec-1S would restore mitochondrial and autophago-lysosomal function.T2DM was developed in mice by feeding them a high-fat diet (HFD) for 16 weeks and injecting a single dose of streptozotocin (100 mg/kg, i.p) on the 12(th) week. Nec-1S was administered for 3 weeks at (10 mg/kg, i.p) once every 3 days. Lipotoxicity was induced in neuro2A, and BV2 cells using 200 mu M palmitate/bovine serum albumin conjugate. Nec-1S (50 mu M), and GSK-872(10 mu M) were further used to explore their relative effect. The neurobehavioral performance was assessed using mazes and task-assisted performance tests. To decipher the hypothesis plasma parameters, western blot, immunofluorescence, microscopy, and quantitative reverse transcription-PCR studies were carried out. The Nec-1S treatment restored cognitive performance and reduced the p-RIPK-p-RIPK3-p-MLKL mediated neuro-microglia changes in the brain and in cells as well, under lipotoxic stress. Nec-1S reduced tau, and amyloid oligomer load. Moreover, Nec-1S restored mitochondrial function and autophago-lysosome clearance. The findings highlight the central impact of metabolic syndrome and how Nes-1S, by acting as a multifaceted agent, improved central functioning.
C1 [Preeti, Kumari; Fernandes, Valencia; Sood, Anika; Khan, Islauddin; Khatri, Dharmendra Kumar; Singh, Shashi Bala] Natl Inst Pharmaceut Educ & Res NIPER Hyderabad, Dept Pharmacol & Toxicol, Hyderabad 500037, Telangana, India.
   [Khatri, Dharmendra Kumar] Natl Inst Pharmaceut Educ & Res NIPER Hyderabad, Dept Pharmacol & Toxicol, Mol & Cellular Neurosci Lab, Hyderabad 500037, Telangana, India.
C3 National Institute of Pharmaceutical Education & Research, Hyderabad;
   National Institute of Pharmaceutical Education & Research, Hyderabad
RP Khatri, DK; Singh, SB (corresponding author), Natl Inst Pharmaceut Educ & Res NIPER Hyderabad, Dept Pharmacol & Toxicol, Hyderabad 500037, Telangana, India.; Khatri, DK (corresponding author), Natl Inst Pharmaceut Educ & Res NIPER Hyderabad, Dept Pharmacol & Toxicol, Mol & Cellular Neurosci Lab, Hyderabad 500037, Telangana, India.
EM dkkhatri10@gmail.com; sbsingh.dipas@gmail.com
RI preeti, kumari/LNQ-1525-2024; KHATRI, DHARMENDRA KUMAR/I-5905-2013
OI Sood, Anika/0000-0001-5868-428X; KHATRI, DHARMENDRA
   KUMAR/0000-0001-7066-7706; Fernandes, Valencia/0000-0002-6212-5947
FU Department of Pharmaceuticals, Ministry of Chemicals and Fertilizers,
   Government of India
FX Authors would like to acknowledge the financial support provided by the
   Department of Pharmaceuticals, Ministry of Chemicals and Fertilizers,
   Government of India for carrying out the present research work.
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NR 88
TC 10
Z9 10
U1 0
U2 4
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0885-7490
EI 1573-7365
J9 METAB BRAIN DIS
JI Metab. Brain Dis.
PD JUN
PY 2023
VL 38
IS 5
SI SI
BP 1581
EP 1612
DI 10.1007/s11011-023-01185-8
EA MAR 2023
PG 32
WC Endocrinology & Metabolism; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology
GA AV8H5
UT WOS:000947267800001
PM 36897515
DA 2025-06-11
ER

PT J
AU Greene, GW
   White, AA
   Hoerr, SL
   Lohse, B
   Schembre, SM
   Riebe, D
   Patterson, J
   Kattelmann, KK
   Shoff, S
   Horacek, T
   Blissmer, B
   Phillips, BW
AF Greene, Geoffrey W.
   White, Adrienne A.
   Hoerr, Sharon L.
   Lohse, Barbara
   Schembre, Susan M.
   Riebe, Deborah
   Patterson, Jill
   Kattelmann, Kendra K.
   Shoff, Suzanne
   Horacek, Tanya
   Blissmer, Bryan
   Phillips, Beatrice W.
TI Impact of an Online Healthful Eating and Physical Activity Program for
   College Students
SO AMERICAN JOURNAL OF HEALTH PROMOTION
LA English
DT Article
DE Intervention Study; Universities; Health; Behavior; Online; Prevention
   Research
ID YOUNG-ADULTS; METABOLIC SYNDROME; BODY-WEIGHT; LIFE-STYLE; INTERVENTION;
   FRUIT; COMPETENCE; RELIABILITY; FRESHMAN; EXERCISE
AB Purpose. To identify impact of an online nutrition and physical activity program for college students.
   Design. Randomized, controlled trial using online questionnaires and on-site physical and fitness assessments with measurement intervals of 0 (baseline), 3 (postintervention), and 15 months (follow-up).
   Setting. Online intervention delivered to college students; a centralized Web site was used for recruitment, data collection, data management, and intervention delivery.
   Subjects. College students (18-24 years old, n = 1689), from eight universities (Michigan State University, South Dakota State University, Syracuse University, The Pennsylvania State University, Tuskegee University, University of Rhode Island, University of Maine, and University of Wisconsin).
   Intervention. A 10-lesson curriculum focusing on healthful eating and physical activity, stressing nondieting principles such as size acceptance and eating competence (software developer: Rainstorm, Inc, Orono, Maine).
   Measures. Measurements included anthropometrics, cardiorespiratory fitness, fruit/vegetable (FV) intake, eating competence, physical activity, and psychosocial stress.
   Analysis. Repeated measures analysis of variance for outcome variables.
   Results. Most subjects were white, undergraduate females (63%), with 25% either overweight or obese. Treatment group completion rate for the curriculum was 84%. Over 15 months, the treatment group had significantly higher FV intake (+.5 cups/d) and physical activity participation (+270 metabolic equivalent minutes per week) than controls. For both groups, anthropometric values and stress increased, and fitness levels decreased. Gender differences were present for most variables. First-year males and females gained more weight than participants in other school years.
   Conclusion. A 10-week online nutrition and physical activity intervention to encourage competence in making healthful food and eating decisions had a positive, lasting effect on FV intake and maintained baseline levels of physical activity in a population that otherwise experiences significant declines in these healthful behaviors. (Am J Health Promot 2012;27[2]:e47-e58.)
C1 [Greene, Geoffrey W.] Univ Rhode Isl, Dept Nutr & Food Sci, Kingston, RI 02881 USA.
   [Riebe, Deborah; Blissmer, Bryan] Univ Rhode Isl, Dept Kinesiol, Kingston, RI 02881 USA.
   [White, Adrienne A.] Univ Maine, Dept Food Sci & Human Nutr, Orono, ME USA.
   [Hoerr, Sharon L.] Michigan State Univ, Dept Food Sci & Human Nutr, E Lansing, MI 48824 USA.
   [Lohse, Barbara; Patterson, Jill] Penn State Univ, Dept Nutr Sci, University Pk, PA 16802 USA.
   [Schembre, Susan M.] Univ Hawaii, Prevent & Control Program, Ctr Canc, Honolulu, HI 96822 USA.
   [Kattelmann, Kendra K.] S Dakota State Univ, Hlth & Nutr Sci Dept, Brookings, SD 57007 USA.
   [Shoff, Suzanne] Univ Wisconsin, Dept Nutr Sci, Madison, WI 53706 USA.
   [Horacek, Tanya] Syracuse Univ, Dept Publ Hlth Food Studies & Nutr, David B Falk Coll Sports Management & Human Dynam, Syracuse, NY USA.
   [Phillips, Beatrice W.] Tuskegee Univ, Dept Food & Nutr Sci, Tuskegee, AL 36088 USA.
C3 University of Rhode Island; University of Rhode Island; University of
   Maine System; University of Maine Orono; Michigan State University;
   Pennsylvania Commonwealth System of Higher Education (PCSHE);
   Pennsylvania State University; Penn State Behrend; Pennsylvania State
   University - University Park; Cancer Research Center of Hawaii;
   University of Hawaii System; South Dakota State University; University
   of Wisconsin System; University of Wisconsin Madison; Syracuse
   University; Tuskegee University
RP Greene, GW (corresponding author), Univ Rhode Isl, Dept Nutr & Food Sci, 10 Ranger Rd,106 Ranger Hall, Kingston, RI 02881 USA.
EM gwg@uri.edu
RI Horacek, Tanya/D-6355-2013; Blissmer, Bryan/HPH-2730-2023; Kattelmann,
   Kendra/AAC-8629-2020
OI Kattelmann, Kendra/0000-0002-6186-2822; Horacek,
   Tanya/0000-0002-6069-9939; Schembre, Susan/0000-0002-9945-7136
FU NCRR NIH HHS [M01 RR10732] Funding Source: Medline
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NR 68
TC 104
Z9 126
U1 0
U2 107
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0890-1171
EI 2168-6602
J9 AM J HEALTH PROMOT
JI Am. J. Health Promot.
PD NOV-DEC
PY 2012
VL 27
IS 2
BP E47
EP E58
DI 10.4278/ajhp.110606-QUAN-239
PG 12
WC Public, Environmental & Occupational Health
WE Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA 052VP
UT WOS:000312227200006
PM 23113786
DA 2025-06-11
ER

PT J
AU Tsuchida, T
   Shiraishi, M
   Ohta, T
   Sakai, K
   Ishii, S
AF Tsuchida, Takuma
   Shiraishi, Muneshige
   Ohta, Tetsuya
   Sakai, Kaoru
   Ishii, Shinichi
TI Ursodeoxycholic acid improves insulin sensitivity and hepatic steatosis
   by inducing the excretion of hepatic lipids in high-fat diet-fed
   KK-A<SUP>y</SUP> mice
SO METABOLISM-CLINICAL AND EXPERIMENTAL
LA English
DT Article
ID ALANINE AMINOTRANSFERASE; NUCLEAR RECEPTOR; LIVER-INJURY; RISK;
   INHIBITION; ELEVATIONS; RESISTANCE; STRESS; TISSUE; MEN
AB Type 2 diabetes mellitus is frequently accompanied by fatty liver/nonalcoholic fatty liver disease. Hence, accumulation of lipids in the liver is considered to be one of the risk factors for insulin resistance and metabolic syndrome. Ursodeoxycholic acid (UDCA) is widely used for the treatment of liver dysfunction. We investigated the therapeutic effects of UDCA on type 2 diabetes mellitus exacerbating hepatic steatosis and the underlying mechanisms of its action using KK-A(y) mice fed a high-fat diet. KK-A(y) mice were prefed a high-fat diet; and 50, 150, and 450 mg/kg of UDCA was orally administered for 2 or 3 weeks. Administration of UDCA decreased fasting hyperglycemia and hyperinsulinemia. Hyperinsulinemic-euglycemic clamp analyses showed that UDCA improved hepatic (but not peripheral) insulin resistance. Hepatic triglyceride and cholesterol contents were significantly reduced by treatment with UDCA, although the genes involved in the synthesis of fatty acids and cholesterol, including fatty acid synthase and 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase, were upregulated. Fecal levels of bile acids, neutral sterols, fatty acids, and phospholipids were significantly increased by UDCA treatment. The gene expression levels and protein phosphorylation levels of endoplasmic reticulum stress markers were not changed by UDCA treatment. These results indicate that UDCA ameliorates hyperglycemia and hyperinsulinemia by improving hepatic insulin resistance and steatosis in high-fat diet-fed KK-A(y) mice. Reduction of hepatic lipids might be due to their excretion in feces, followed by enhanced utilization of glucose for the synthesis of fatty acids and cholesterol. Ursodeoxycholic acid should be effective for the treatment of type 2 diabetes mellitus accompanying hepatic steatosis. (c) 2012 Elsevier Inc. All rights reserved.
C1 [Tsuchida, Takuma; Shiraishi, Muneshige; Sakai, Kaoru; Ishii, Shinichi] Mitsubishi Tanabe Pharma Corp, Div Res, Pharmacol Res Labs 2, Dept 1, Saitama 3358505, Japan.
   [Ohta, Tetsuya] Mitsubishi Tanabe Pharma Corp, Div Res, Adv Med Res Labs, Target Discovery & Biomarker Res Dept, Yokohama, Kanagawa 2270033, Japan.
C3 Mitsubishi International Corporation (MIC); Mitsubishi Tanabe Pharma
   Corporation; Mitsubishi International Corporation (MIC); Mitsubishi
   Tanabe Pharma Corporation
RP Tsuchida, T (corresponding author), Mitsubishi Tanabe Pharma Corp, Div Res, Pharmacol Res Labs 2, Dept 1, Saitama 3358505, Japan.
EM tsuchida.takuma@mx.mt-pharma.co.jp
RI Sakai, Kaoru/HGE-2792-2022
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NR 27
TC 59
Z9 63
U1 0
U2 20
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0026-0495
EI 1532-8600
J9 METABOLISM
JI Metab.-Clin. Exp.
PD JUL
PY 2012
VL 61
IS 7
BP 944
EP 953
DI 10.1016/j.metabol.2011.10.023
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 960EV
UT WOS:000305371700006
PM 22154323
DA 2025-06-11
ER

PT J
AU Mozaffari, MS
   AbdelSayed, R
   Liu, JY
   Wimborne, H
   El-Remessy, A
   El-Marakby, A
AF Mozaffari, Mahmood S.
   AbdelSayed, Rafik
   Liu, Jun Yao
   Wimborne, Hereward
   El-Remessy, Azza
   El-Marakby, Ahmed
TI Effects of chromium picolinate on glycemic control and kidney of the
   obese Zucker rat
SO NUTRITION & METABOLISM
LA English
DT Article
ID PRODUCE CHROMOSOME-DAMAGE; NUTRITIONAL SUPPLEMENT; INSULIN SENSITIVITY;
   METABOLIC SYNDROME; FATTY RATS; CELLS; DNA; MECHANISMS; TOXICITY; BLOOD
AB Background: Chromium picolinate (Cr(pic)3) is advocated as adjuvant therapy for impaired glycemic control, despite concerns for DNA damage. Potential toxicity of Cr(pic)3 should be greater for the kidney that accumulates chromium. Therefore, we tested the hypothesis that Cr(pic)3 treatment of obese Zucker rats (OZR) exacerbates renal abnormalities associated with dysglycemia.
   Methods: Male OZR were treated with diets lacking or containing 5 and 10 mg/kg of chromium, as Cr(pic)3, for 20 weeks; lean Zucker rats (LZR) served as controls. Glycemic and renal effects of Cr(pic)3 were determined in the context of indices of oxidative stress and inflammation.
   Results: The OZR displayed increased fasting plasma glucose and insulin in association with enlarged pancreatic islets exhibiting collagen and periodic acid Schiff-positive deposits compared to LZR; Cr(pic)3 treatment did not affect these parameters. The OZR, irrespective of Cr(pic)3, excreted more albumin than LZR. Also, other indices of renal function or histopathology were not affected by Cr(pic)3 treatment. Urinary excretion of 8-hydroxydeoxyguanosine (8-OHdG), an index of oxidative DNA damage, was greater in the OZR than LZR; dietary Cr(pic)3 treatment attenuated 8-OHdG excretion. However, immunostaining of kidney for 8-OHdG revealed similar staining pattern and intensity, despite significant renal accumulation of chromium in Cr(pic)3-treated groups. Finally, increased renal nitrotyrosine and cyclooxygenase-2 levels and urinary excretion of monocyte chemoattractant protein-1 of OZR were partially reversed by Cr(pic)3 treatment.
   Conclusion: Dietary Cr(pic)3 treatment of OZR does not beneficially influence glycemic status or increase the risk for oxidative DNA damage; rather, the treatment attenuates indices of oxidative stress and inflammation.
C1 [Mozaffari, Mahmood S.; Liu, Jun Yao; Wimborne, Hereward; El-Marakby, Ahmed] Med Coll Georgia, Sch Dent, Dept Oral Biol, Augusta, GA 30912 USA.
   [AbdelSayed, Rafik] Med Coll Georgia, Sch Dent, Dept Oral Hlth & Diagnost Sci, Augusta, GA 30912 USA.
   [El-Remessy, Azza] Univ Georgia, Coll Pharm, Augusta, GA 30912 USA.
C3 University System of Georgia; Augusta University; University System of
   Georgia; Augusta University; University System of Georgia; University of
   Georgia
RP Mozaffari, MS (corresponding author), Med Coll Georgia, Sch Dent, Dept Oral Biol, Augusta, GA 30912 USA.
EM Mmozaffa@mail.mcg.edu; Rabdelsa@mail.mcg.edu; Jyliu@mail.mcg.edu;
   Hwimborne@mail.mcg.edu; Aelremessy@mail.mcg.edu; Aelmarakby@mail.mcg.edu
RI Elmarakby, Ahmed/ABF-5055-2021; El-Remessy, Azza/AAA-3771-2020
OI El-Remessy, Azza/0000-0003-4386-1989
FU National Institutes of Health [1R21AT003012-01A2]
FX This study was entirely supported by a grant from the National
   Institutes of Health (1R21AT003012-01A2; MSM).
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NR 37
TC 18
Z9 19
U1 0
U2 2
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1743-7075
J9 NUTR METAB
JI Nutr. Metab.
PD DEC 10
PY 2009
VL 6
AR 51
DI 10.1186/1743-7075-6-51
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 539UD
UT WOS:000273283000001
PM 20003253
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Nakajima, K
   Yamasaki, Y
   Kusuoka, H
   Izumi, T
   Kashiwagi, A
   Kawamori, R
   Shimamoto, K
   Yamada, N
   Nishimura, T
AF Nakajima, Kenichi
   Yamasaki, Yoshimitsu
   Kusuoka, Hideo
   Izumi, Tohru
   Kashiwagi, Atsunori
   Kawamori, Ryuzo
   Shimamoto, Kazuaki
   Yamada, Nobuhiro
   Nishimura, Tsunehiko
TI Cardiovascular events in Japanese asymptomatic patients with type 2
   diabetes: a 1-year interim report of a J-ACCESS 2 investigation using
   myocardial perfusion imaging
SO EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
LA English
DT Article
DE Asymptomatic diabetes mellitus; Coronary artery disease; Gated
   myocardial perfusion imaging; Tc-99m-Tetrofosmin; Prognosis
ID EMISSION COMPUTED-TOMOGRAPHY; ISCHEMIC-HEART-DISEASE; RISK
   STRATIFICATION; PROGNOSTIC VALUE; METABOLIC SYNDROME; CLINICAL
   CONSEQUENCES; EJECTION FRACTION; VASCULAR-DISEASE; MEDICAL THERAPY;
   GATED SPECT
AB Diabetic patients have a high risk for cardiovascular events. The role of myocardial perfusion imaging was investigated in asymptomatic diabetic patients to evaluate short-term prognosis in a Japanese population.
   A total of 506 asymptomatic patients a parts per thousand yen50 years of age who had carotid artery maximum intima-media thickness a parts per thousand yen1.1 mm, urinary albumin excretion of a parts per thousand yen30 mg/g creatinine, with additional criteria of abdominal obesity, low HDL cholesterol, high triglyceride level, and hypertension were enrolled and followed up over a 3-year period. Gated SPECT with stress-rest protocol was performed and analyzed by summed defect scores and QGS software. One-year cardiovascular events were analyzed.
   Myocardial ischemia was observed in 17% of patients, and abnormal perfusion findings of ischemia and/or scar were observed in 32% of patients. By the end of the 1-year follow-up, 33 (6.5%) cardiovascular events occurred including 6 all-cause deaths. Patients with summed stress score (SSS) > 8 had a higher incidence of either death or cardiovascular events. Event-free survival rates for SSS 0-3, 4-8, 9-13, and a parts per thousand yen14 were 0.96, 0.95, 0.82, and 0.76, respectively. Multivariate Cox regression analysis showed that significant variables were SSS, history of cerebrovascular accident, and electrocardiographic abnormality at rest.
   The 1-year interim summary showed that cardiovascular events were significantly higher in patients with SPECT abnormality, although hard cardiac event rate was relatively low. Targeted treatment strategy is required for asymptomatic but potentially high-risk diabetic patients.
C1 [Nakajima, Kenichi] Kanazawa Univ Hosp, Dept Nucl Med, Kanazawa, Ishikawa 9208641, Japan.
   [Yamasaki, Yoshimitsu] Osaka Univ, Ctr Adv Sci & Innovat, Osaka, Japan.
   [Kusuoka, Hideo] Osaka Natl Hosp, Natl Hosp Org, Osaka, Japan.
   [Izumi, Tohru] Kitasato Univ, Dept Cardiol & Internal Med, Sagamihara, Kanagawa 228, Japan.
   [Kashiwagi, Atsunori] Shiga Univ Med Sci, Dept Med, Otsu, Shiga, Japan.
   [Kawamori, Ryuzo] Juntendo Univ, Sch Med, Dept Med Metab & Endocrinol, Tokyo 113, Japan.
   [Shimamoto, Kazuaki] Sapporo Med Univ, Sch Med, Dept Internal Med 2, Sapporo, Hokkaido, Japan.
   [Yamada, Nobuhiro] Univ Tsukuba, Fac Med, Dept Internal Med, Div Endocrinol & Metab, Tsukuba, Ibaraki, Japan.
   [Nishimura, Tsunehiko] Kyoto Prefectural Univ Med, Dept Radiol, Grad Sch Med Sci, Hirokoji Kamigyo Ku, Kyoto 6028566, Japan.
C3 Kanazawa University; The University of Osaka; Osaka National Hospital;
   Kitasato University; Shiga University of Medical Science; Juntendo
   University; Sapporo Medical University; University of Tsukuba; Kyoto
   Prefectural University of Medicine
RP Nakajima, K (corresponding author), Kanazawa Univ Hosp, Dept Nucl Med, 13-1 Takara Machi, Kanazawa, Ishikawa 9208641, Japan.
EM nakajima@med.kanazawa-u.ac.jp; nisimura@koto.kpu-m.ac.jp
RI Kashiwagi, Atsunori/H-8712-2019
FU Japan Cardiovascular Research Foundation
FX The J-ACCESS 2 study was supported by a grant from the Japan
   Cardiovascular Research Foundation. We acknowledge the work of all
   investigators of the J-ACCESS 2 investigation [ 16].
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NR 31
TC 28
Z9 29
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1619-7070
EI 1619-7089
J9 EUR J NUCL MED MOL I
JI Eur. J. Nucl. Med. Mol. Imaging
PD DEC
PY 2009
VL 36
IS 12
BP 2049
EP 2057
DI 10.1007/s00259-009-1207-9
PG 9
WC Radiology, Nuclear Medicine & Medical Imaging
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Radiology, Nuclear Medicine & Medical Imaging
GA 522DZ
UT WOS:000271979300015
PM 19593560
DA 2025-06-11
ER

PT J
AU Capeau, J
AF Capeau, J.
TI Insulin resistance and steatosis in humans
SO DIABETES & METABOLISM
LA English
DT Article
DE Insulin; Steatosis; Adipose tissue; Liver; Triglycerides; Lipogenesis;
   Hepatic glucose production; Free fatty acids; Lipotoxicity; Review
ID FATTY LIVER-DISEASE; NONALCOHOLIC STEATOHEPATITIS; ADIPOSE-TISSUE;
   TRANSCRIPTION FACTOR; HEPATIC STEATOSIS; GENE-EXPRESSION; INNATE
   IMMUNITY; DIETARY-FAT; ADIPONECTIN; INFLAMMATION
AB Insulin resistance is commonly found in a large number of adults-in particular, those with android obesity, the metabolic syndrome or type 2 diabetes. Strong adverse relationships between adipose tissue, liver and muscles in these patients result in lipotoxicity, with deposition of trigly-cerides (TG) within the liver and muscles together with insulin resistance. Such a situation is also seen in lipodystrophic patients with fat loss. Insulin signals in the liver through its tyrosine-kinase receptors to negatively control hepatic glucose production (HGP), replenish glycogen stores and synthesize fatty acids (FA), leading to TG exported as VLDL. In liver insulin resistance, HGP is increased mainly by activation of the gluconeogenic pathway, resulting in increased fasting glycemia. Lipogenesis is also increased possibly due to direct activation of the SREBPI transcription factor and together with increased FA availability results in an increased production of VLDL-TG. An imbalance between the pathways of TG synthesis and oxidation or export results in 'metebolic' steatosis. Increased cellular FA derivatives activate stress kinases, leading to phosphorylation of serine in insulin receptor substrate (IRS) proteins and, hence, insulin resistance. A number of studies in normal subjects and patients have revealed a strong association between insulin resistance and metabolic steatosis. Moreover, when insulin resistance is decreased by weight loss in obese subjects or by treatment with insulin sensitizers such as thiazolidinediones, the levels of liver fat and insulin resistance vary accordingly. An important question that remains unanswered concerns the relationship between steatosis and non-alcoholic steatohepatitis (NASH), and the potential roles of insulin resistance together with inflammation and oxidative stress in such a setting. (C) 2008 Elsevier Masson SAS. All rights reserved.
C1 [Capeau, J.] Univ Paris 06, INSERM, Equipe 9, Fac Med Pierre & Marie Curie, F-75571 Paris 12, France.
   [Capeau, J.] Hop Tenon, APHP, F-75020 Paris, France.
C3 Institut National de la Sante et de la Recherche Medicale (Inserm);
   Sorbonne Universite; Assistance Publique Hopitaux Paris (APHP); Hopital
   Universitaire Ambroise-Pare - APHP; Sorbonne Universite; Hopital
   Universitaire Tenon - APHP; Universite Paris Cite; Hopital Universitaire
   Hotel-Dieu - APHP
RP Capeau, J (corresponding author), Univ Paris 06, INSERM, Equipe 9, Fac Med Pierre & Marie Curie, Site St Antonie 27,Rue Chaligny, F-75571 Paris 12, France.
EM jacqueline.capeau@inserm.fr
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NR 41
TC 90
Z9 107
U1 0
U2 5
PU MASSON EDITEUR
PI MOULINEAUX CEDEX 9
PA 21 STREET CAMILLE DESMOULINS, ISSY, 92789 MOULINEAUX CEDEX 9, FRANCE
SN 1262-3636
EI 1878-1780
J9 DIABETES METAB
JI Diabetes Metab.
PD DEC
PY 2008
VL 34
IS 6
BP 649
EP 657
DI 10.1016/S1262-3636(08)74600-7
PN 2
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 389GZ
UT WOS:000262081800005
PM 19195626
DA 2025-06-11
ER

PT J
AU von Känel, R
   Dimsdale, JE
   Mills, PJ
   Ancoli-Israel, S
   Patterson, TL
   Mausbach, BT
   Grant, I
AF von Kaenel, Roland
   Dimsdale, Joel E.
   Mills, Paul J.
   Ancoli-Israel, Sonia
   Patterson, Thomas L.
   Mausbach, Brent T.
   Grant, Igor
TI Effect of Alzheimer caregiving stress and age on frailty markers
   interleukin-6, C-reactive protein, and D-dimer
SO JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL
   SCIENCES
LA English
DT Article
ID FIBRIN D-DIMER; CORONARY-HEART-DISEASE; CARDIOVASCULAR-DISEASE;
   ACTIVATION MARKERS; METABOLIC SYNDROME; INFLAMMATION; HEALTH;
   COAGULATION; RISK; POLYMORPHISM
AB Background. Elevated plasma levels of interleukin (IL)-6, C-reactive protein (CRP), and D-dimer belong to the biological alterations of the "frailty syndrome," defining increased vulnerability for diseases and mortality with aging. We hypothesized that, compatible with premature frailty, chronic stress and age are related in predicting inflammation and coagulation activity in Alzheimer caregivers.
   Methods. Plasma IL-6, CRP, and D-dimer levels were measured in 170 individuals (mean age 73 +/- 9 years; 116 caregivers, 54 noncaregiving controls). Demographic factors, diseases, drugs, and lifestyle variables potentially affecting inflammation and coagulation were obtained by history and adjusted for as covariates in statistical analyses.
   Results. Caregivers had higher mean levels of IL-6 (1.38 +/- 1.42 vs 1.00 +/- 0.92 pg/mL, p =.032) and of D-dimer (723 +/- 530 vs 471 +/- 211 ng/mL, p < .001) than controls had. CRP levels were similar between groups (p = .44). The relationship between caregiver status and D-dimer was independent of covariates (p = .037) but affected by role overload. Age accounted for much of the relationship with IL-6. After controlling for covariates, the interaction between caregiver status and age was significant for D-dimer (P = .20, p = .029) and of borderline significance for IL-6 (beta = .17, p = .090). Post hoe regression analyses indicated that, among caregivers, age was significantly correlated with both D-dimer (P=.50, p < .001) and IL-6 (beta=.38, p = .001). Among controls, however, no significant relationship was observed between age and either D-dimer or IL-6.
   Conclusions. The interaction between caregiving status and age for D-dimer and IL-6 suggests the possibility that older caregivers could be at risk of a more rapid transition to the frailty syndrome and clinical manifestations of cardiovascular diseases.
C1 Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA.
   Univ Hosp, Dept Gen Internal Med, Div Psychosomat Med, Bern, Switzerland.
   Vet Affairs San Diego Healthcare Syst, La Jolla, CA USA.
C3 University of California System; University of California San Diego;
   University of Bern; University Hospital of Bern; US Department of
   Veterans Affairs; Veterans Health Administration (VHA); VA San Diego
   Healthcare System
RP Grant, I (corresponding author), Univ Calif San Diego, Dept Psychiat, 9500 Gilman Dr, La Jolla, CA 92093 USA.
EM igrant@ucsd.edu
RI ; von Kanel, Roland/B-1811-2019
OI Mausbach, Brent/0000-0003-2884-8743; von Kanel,
   Roland/0000-0002-8929-5129
FU NIA NIH HHS [AG 15301] Funding Source: Medline
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NR 44
TC 140
Z9 160
U1 0
U2 10
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1079-5006
EI 1758-535X
J9 J GERONTOL A-BIOL
JI J. Gerontol. Ser. A-Biol. Sci. Med. Sci.
PD SEP
PY 2006
VL 61
IS 9
BP 963
EP 969
DI 10.1093/gerona/61.9.963
PG 7
WC Geriatrics & Gerontology; Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA 085CP
UT WOS:000240581100011
PM 16960028
OA Green Published
DA 2025-06-11
ER

PT J
AU Musolino, V
   Gliozzi, M
   Scarano, F
   Bosco, F
   Scicchitano, M
   Nucera, S
   Carresi, C
   Ruga, S
   Zito, MC
   Maiuolo, J
   Macrì, R
   Amodio, N
   Juli, G
   Tassone, P
   Mollace, R
   Caffrey, R
   Marioneaux, J
   Walker, R
   Ehrlich, J
   Palma, E
   Muscoli, C
   Bedossa, P
   Salvemini, D
   Mollace, V
   Sanyal, AJ
AF Musolino, Vincenzo
   Gliozzi, Micaela
   Scarano, Federica
   Bosco, Francesca
   Scicchitano, Miriam
   Nucera, Saverio
   Carresi, Cristina
   Ruga, Stefano
   Zito, Maria Caterina
   Maiuolo, Jessica
   Macri, Roberta
   Amodio, Nicola
   Juli, Giada
   Tassone, Pierfrancesco
   Mollace, Rocco
   Caffrey, Rebecca
   Marioneaux, Jonathon
   Walker, Ross
   Ehrlich, James
   Palma, Ernesto
   Muscoli, Carolina
   Bedossa, Pierre
   Salvemini, Daniela
   Mollace, Vincenzo
   Sanyal, Arun J.
TI Bergamot Polyphenols Improve Dyslipidemia and Pathophysiological
   Features in a Mouse Model of Non-Alcoholic Fatty Liver Disease
SO SCIENTIFIC REPORTS
LA English
DT Article
ID LOW-DENSITY-LIPOPROTEIN; SINUSOIDAL ENDOTHELIAL-CELLS; IN-VIVO; AMERICAN
   ASSOCIATION; INSULIN-RESISTANCE; SCORING SYSTEM; ANIMAL-MODEL;
   STEATOHEPATITIS; CHOLESTEROL; ANTIOXIDANT
AB There is a need for continued drug development for nonalcoholic steatohepatitis (NASH). Bergamot is a plant whose fruit juice is enriched with flavonoids and phenolic compounds which improves dyslipidemia and markers of systemic inflammation in patients with Metabolic Syndrome. The aim of this study was to perform a preclinical "proof of concept" study of Bergamot polyphenolic formulation (BPF99) for the treatment of NASH. A disease reversal study was performed in the diet-induced animal model of NAFLD (DIAMOND). Groups of 8 weeks old mice were randomly assigned to receive chow diet, high fat diet with sugar in drinking water (Western diet-WD). Mice on WD were further randomized to continue on WD gavaged with vehicle or continue on WD with additional gavage of BPF99 (50 mg/kg) after 16 weeks of diet. Mice were euthanized after 11 additional weeks. The primary endpoint was resolution of NASH. Secondary endpoints included changes in individual histological features, body weight, liver enzymes, dyslipidemia, markers of oxidative stress and molecular markers of disease activity and fibrosis. The results showed that BPF99 reduced ALT (mean 71.6 vs 44.6 IU/l, p < 0.01), triglycerides (38.8 vs 28.1 mg/dl, p < 0.05), LDL-C (39.2 vs 23.7 mg/dl, p < 0.001). It significantly improved NASH resolution (p < 0.001) and the SAF scores (p < 0.05) while the NAS improvement approached significance. BPF99 reduced markers of oxidative stress, along with reduced JNK and p38 MAP kinase activity. BPF99 did not reduce the number of mice with fibrosis but improved collagen proportional area (p < 0.04) and procollagen I and III expression. Collectively our results showed that BPF99 resolves NASH and ameliorates key histological and pathophysiological features of NASH along with improvement in ALT and dyslipidemia in the DIAMOND mice.
C1 [Musolino, Vincenzo; Gliozzi, Micaela; Scarano, Federica; Bosco, Francesca; Scicchitano, Miriam; Nucera, Saverio; Carresi, Cristina; Ruga, Stefano; Zito, Maria Caterina; Maiuolo, Jessica; Macri, Roberta; Mollace, Rocco; Palma, Ernesto; Muscoli, Carolina; Mollace, Vincenzo] Magna Graecia Univ Catanzaro, Inst Res Food Safety & Hlth IRC FSH, Dept Hlth Sci, Catanzaro, Italy.
   [Musolino, Vincenzo; Gliozzi, Micaela; Scarano, Federica; Bosco, Francesca; Scicchitano, Miriam; Nucera, Saverio; Carresi, Cristina; Ruga, Stefano; Zito, Maria Caterina; Maiuolo, Jessica; Macri, Roberta; Mollace, Rocco; Palma, Ernesto; Muscoli, Carolina; Mollace, Vincenzo] Nutramed Scarl Complesso Nini Barbieri, Catanzaro, Italy.
   [Amodio, Nicola; Juli, Giada; Tassone, Pierfrancesco] Magna Graecia Univ Catanzaro, Dept Expt & Clin Med, Catanzaro, Italy.
   [Caffrey, Rebecca; Marioneaux, Jonathon; Sanyal, Arun J.] Sanyal Biotechnol, 800 E Leigh St, Richmond, VA 23219 USA.
   [Walker, Ross] Macquarie Univ, Med Sch, Sydney, NSW, Australia.
   [Ehrlich, James] Univ Colorado, Denver, CO 80202 USA.
   [Bedossa, Pierre] Liverpat, Paris, France.
   [Bedossa, Pierre] Univ Newcastle, Inst Cellular Med, Newcastle, England.
   [Salvemini, Daniela] St Louis Univ, Dept Pharmacol & Physiol, Sch Med, 1402 South Grand Blvd, St Louis, MO 63104 USA.
C3 Magna Graecia University of Catanzaro; Magna Graecia University of
   Catanzaro; Macquarie University; University of Colorado System;
   University of Colorado Denver; Newcastle University - UK; Saint Louis
   University
RP Musolino, V (corresponding author), Magna Graecia Univ Catanzaro, Inst Res Food Safety & Hlth IRC FSH, Dept Hlth Sci, Catanzaro, Italy.; Musolino, V (corresponding author), Nutramed Scarl Complesso Nini Barbieri, Catanzaro, Italy.; Sanyal, AJ (corresponding author), Sanyal Biotechnol, 800 E Leigh St, Richmond, VA 23219 USA.
EM xabaras3@hotmail.com; arunjsanyal@gmail.com
RI Maiuolo, Jessica/AAU-2482-2020; SCARANO, FEDERICA/HNC-2414-2023;
   Tassone, Pierfrancesco/AIA-5373-2022; carresi, cristina/AAC-6354-2022;
   Gliozzi, Micaela/D-4405-2015; Ruga, Stefano/JUV-6384-2023; Mollace,
   Rocco/ABH-5643-2020; Amodio, Nicola/K-7335-2016; Bosco,
   Francesca/HPF-0108-2023; Musolino, Vincenzo/AAC-6429-2022; MACRI',
   Roberta/AAC-5967-2022; nucera, saverio/AAC-6570-2022; Muscoli,
   Carolina/G-2773-2011
OI SCARANO, FEDERICA/0000-0002-9838-9469; Mollace,
   Rocco/0000-0002-7106-5595; MACRI', Roberta/0000-0002-2345-6751; Tassone,
   Pierfrancesco/0000-0002-8298-6787; carresi,
   cristina/0000-0002-3509-5930; Bosco, Francesca/0009-0004-4766-9710;
   nucera, saverio/0000-0002-0000-4015; Juli, Giada/0000-0002-5317-6144;
   Musolino, Vincenzo/0000-0002-4763-2211; Ruga,
   Stefano/0009-0008-0401-4027
FU Hepatic Sciences Inc.; Herbal & Antioxidant Derivatives Srl (H.& A.D.
   Srl, Bianco, Reggio Calabria, Italy); Programma Operativo Nazionale,
   PON-MIUR [A3 000359];  [03PE000_78_1];  [03PE000_78_2 -Nutramed]
FX We thank Dr. Jan Morovic for his support in image elaboration. This
   study was supported by Hepatic Sciences Inc., Herbal & Antioxidant
   Derivatives Srl (H.& A.D. Srl, Bianco, Reggio Calabria, Italy),
   Programma Operativo Nazionale, PON-MIUR A3 000359 and by Grant
   03PE000_78_1 and 03PE000_78_2 -Nutramed.
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NR 58
TC 75
Z9 78
U1 4
U2 20
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD FEB 13
PY 2020
VL 10
IS 1
AR 2565
DI 10.1038/s41598-020-59485-3
PG 14
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA MR8MI
UT WOS:000553844600001
PM 32054943
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Menini, S
   Iacobini, C
   Fantauzzi, CB
   Pugliese, G
AF Menini, Stefano
   Iacobini, Carla
   Fantauzzi, Claudia Blasetti
   Pugliese, Giuseppe
TI L-carnosine and its Derivatives as New Therapeutic Agents for the
   Prevention and Treatment of Vascular Complications of Diabetes
SO CURRENT MEDICINAL CHEMISTRY
LA English
DT Review
DE Diabetes; vascular complications; atherosclerosis; diabetic nephropathy;
   carnosine; reactive carbonyl species; advanced glycation end-products;
   metabolic memory
ID ADVANCED GLYCATION ENDPRODUCTS; LOW-DENSITY-LIPOPROTEIN; STAGE
   RENAL-DISEASE; END-PRODUCTS; OXIDATIVE STRESS; GLUCOSE CONTROL;
   FOLLOW-UP; MICROVASCULAR COMPLICATIONS; LIPID-PEROXIDATION; GLYCEMIC
   CONTROL
AB Vascular complications are among the most serious manifestations of diabetes. Atherosclerosis is the main cause of reduced life quality and expectancy in diabetics, whereas diabetic nephropathy and retinopathy are the most common causes of end-stage renal disease and blindness. An effective therapeutic approach to prevent vascular complications should counteract the mechanisms of injury. Among them, the toxic effects of Advanced Glycation (AGEs) and Lipoxidation (ALEs) end-products are well-recognized contributors to these sequelae. L-carnosine (beta-alanyl-L-histidine) acts as a quencher of the AGE/ALE precursors Reactive Carbonyl Species (RCS), which are highly reactive aldehydes derived from oxidative and non-oxidative modifications of sugars and lipids. Consistently, L-carnosine was found to be effective in several disease models in which glyco/lipoxidation plays a central pathogenic role. Unfortunately, in humans, L-camosine is rapidly inactivated by serum camosinase. Therefore, the search for camosinase-resistant derivatives of L-carnosine represents a suitable strategy against carbonyl stress-dependent disorders, particularly diabetic vascular complications. In this review, we present and discuss available data on the efficacy of L-carnosine and its derivatives in preventing vascular complications in rodent models of diabetes and metabolic syndrome. We also discuss genetic findings providing evidence for the involvement of the camosinase/L-camosine system in the risk of developing diabetic nephropathy and for preferring the use of camosinase-resistant compounds in human disease. The availability of therapeutic strategies capable to prevent both long-term glucose toxicity, resulting from insufficient glucose lowering therapy, and lipotoxicity may help reduce the clinical and economic burden of vascular complications of diabetes and related metabolic disorders
C1 [Menini, Stefano; Iacobini, Carla; Fantauzzi, Claudia Blasetti; Pugliese, Giuseppe] Univ Roma La Sapienza, Dept Clin & Mol Med, Via Grottarossa 1035, I-00189 Rome, Italy.
C3 Sapienza University Rome
RP Pugliese, G (corresponding author), Univ Roma La Sapienza, Dept Clin & Mol Med, Via Grottarossa 1035, I-00189 Rome, Italy.
EM giuseppe.pugliese@uniroma1.it
RI Menini, Stefano/G-1130-2010
FU Research Foundation of the Italian Society of Diabetology (Associazione
   Diabete Ricerca ONLUS); Sapienza University di Roma-Progetti Ateneo
   2016; Flamma S.p.A., Chignolo d'Isola, Italy [FL-926-16]
FX This work was supported by a research grant of the Research Foundation
   of the Italian Society of Diabetology (Associazione Diabete Ricerca
   ONLUS) to Giuseppe Pugliese; Sapienza University di Roma-Progetti Ateneo
   2016 to Stefano Menini and by an unconditional grant from Flamma S.p.A.,
   Chignolo d'Isola, Italy, that also provided the tested compounds
   DCarnosine Octylester (DCO) and FL-926-16 to Giuseppe Pugliese. The
   sponsors had no role in the design and conduct of the studies,
   collection, management and interpretation of the data, or preparation,
   review and approval of the manuscript.
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NR 134
TC 30
Z9 31
U1 3
U2 23
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 0929-8673
EI 1875-533X
J9 CURR MED CHEM
JI Curr. Med. Chem.
PY 2020
VL 27
IS 11
SI SI
BP 1744
EP 1763
DI 10.2174/0929867326666190711102718
PG 20
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Pharmacology &
   Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
GA LG7MO
UT WOS:000528280500004
PM 31296153
DA 2025-06-11
ER

PT J
AU Jian, TY
   Wu, YX
   Ding, XQ
   Lv, H
   Ma, L
   Zuo, YY
   Ren, BR
   Zhao, L
   Tong, B
   Chen, J
   Li, WL
AF Jian, Tunyu
   Wu, Yuexian
   Ding, Xiaoqin
   Lv, Han
   Ma, Li
   Zuo, Yuanyuan
   Ren, Bingru
   Zhao, Lei
   Tong, Bei
   Chen, Jian
   Li, Weilin
TI A novel sesquiterpene glycoside from Loquat leaf alleviates oleic
   acid-induced steatosis and oxidative stress in HepG2 cells
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Article
DE Loquat (Eriobotrya japonica) leaf); Sesquiterpene glycoside;
   Non-alcoholic fatty liver disease; Cytochrome P450 2E1; c-jun terminal
   kinase
ID FATTY LIVER-DISEASE; NON-ALCOHOLIC STEATOHEPATITIS; CYTOCHROME-P450 2E1
   CYP2E1; ERIOBOTRYA-JAPONICA; NONALCOHOLIC STEATOHEPATITIS; DIET; LEAVES;
   NASH; RATS; MICE
AB Loquat (Eriobotrya japonica) leaf has displayed beneficial effect on metabolic syndrome. In our previously study, total sesquiterpene glycosides (TSG) isolated from Loquat leaf exhibited therapeutic effect on Non-alcoholic fatty liver disease (NAFLD) in vivo, but the accurate active compound remains unknown. Sesquiterpene glycoside 1 (SG1) is a novel compound, which is exclusively isolated from Loquat leaf, but its biological activity has been rarely reported. The present study was designed to evaluate the pharmacological effect of SG1, the main component of TSG, in oleic acid (OA)-induced HepG2 cell model of NAFLD with its related mechanisms of action. In this study, both SG1 and TSG were found to significantly reduce the lipid deposition in the cell model. They could also decrease total cholesterol (TC), triglyceride (TG) and intracellular free fatty acid (FFA) contents. Compared with OA-treated cells, the superoxide dismutase (SOD) level increased, and the malondialdehyde (MDA) and 4-hydroxynonenal levels respectively decreased after the administration of SG1 or TSG. The high dose of SG1 (140 mu g/mL) displayed a similar therapeutic effect as TSG at 200 mu g/mL. Both SG1 and TSG were found to suppress the expression of cytochrome P450 2E1 (CYP2E1) and the phosphorylation of c-jun terminal kinase (JNK) and its downstream target c-Jun in OA-treated cell. These results demonstrate again that TSG are probably the main responsible chemical profiles of Loquat leaf for the treatment of NAFLD, for which it can effectively improve OA-induced steatosis and reduce oxidative stress, probably by downregulating of CYP2E1 expression and JNK/c-Jun phosphorylation, while SG1 may be the principle compound.
C1 [Jian, Tunyu; Wu, Yuexian; Ding, Xiaoqin; Lv, Han; Ma, Li; Zuo, Yuanyuan; Ren, Bingru; Zhao, Lei; Tong, Bei; Chen, Jian; Li, Weilin] Jiangsu Prov & Chinese Acad Sci, Inst Bot, Nanjing 210014, Jiangsu, Peoples R China.
   [Li, Weilin] Nanjing Forestry Univ, Nanjing 210037, Jiangsu, Peoples R China.
C3 Institute of Botany, Jiangsu Province & Chinese Academy of Sciences;
   Nanjing Forestry University
RP Chen, J (corresponding author), Jiangsu Prov & Chinese Acad Sci, Inst Bot, Nanjing 210014, Jiangsu, Peoples R China.
EM chenjian80@aliyun.com
RI Tong, Bei/HGE-8171-2022; Jian, Tunyu/B-5601-2018
OI Zuo, Yuanyuan/0000-0003-2617-7341; Tong, Bei/0000-0002-6863-6019; Jian,
   Tunyu/0000-0002-9814-500X
FU National Natural Science Foundation of China [81703224, 81773885,
   21102058]; Jiangsu Key Laboratory for the Research and Utilization of
   Plant Resources (Institute of Botany, Jiangsu Province) [JSPKLB201502];
   Jiangsu Key Laboratory for the Research and Utilization of Plant
   Resources (Chinese Academy of Sciences) [JSPKLB201502]; Natural Science
   Foundation of Jiangsu Province of China [BK20141387]; Jiangsu Province
   Science and Technology Social Development Plan [BE2015690]; Jiangsu
   Provincial Platform for Conservation and Utilization of Agricultural
   Germplasm
FX This study was supported by the National Natural Science Foundation of
   China (No. 81703224; No. 81773885; No. 21102058), Jiangsu Key Laboratory
   for the Research and Utilization of Plant Resources (Institute of
   Botany, Jiangsu Province and Chinese Academy of Sciences) (No.
   JSPKLB201502), Natural Science Foundation of Jiangsu Province of China
   (No. BK20141387), Jiangsu Province Science and Technology Social
   Development Plan (No. BE2015690). Thanks to the support of The Jiangsu
   Provincial Platform for Conservation and Utilization of Agricultural
   Germplasm.
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NR 38
TC 22
Z9 25
U1 1
U2 50
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI PARIS
PA 23 RUE LINOIS, 75724 PARIS, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD JAN
PY 2018
VL 97
BP 1125
EP 1130
DI 10.1016/j.biopha.2017.11.043
PG 6
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA FR4NC
UT WOS:000419041300135
PM 29136950
DA 2025-06-11
ER

PT J
AU Asha, K
   Singal, A
   Sharma, SB
   Arora, VK
   Aggarwal, A
AF Asha, Kumari
   Singal, Archana
   Sharma, Suman Bala
   Arora, Vinod Kumar
   Aggarwal, Amitesh
TI Dyslipidaemia & oxidative stress in patients of psoriasis: Emerging
   cardiovascular risk factors
SO INDIAN JOURNAL OF MEDICAL RESEARCH
LA English
DT Article
DE Antioxidants; ferric-reducing ability of plasma; glutathione;
   high-sensitivity C-reactive protein; malondialdehyde; oxidative stress;
   psoriasis
ID METABOLIC SYNDROME; ATHEROSCLEROSIS; BLOOD; ANTIOXIDANTS; MECHANISMS;
   DISEASE; EVENTS; MILD
AB Background & objectives: Psoriasis is a recurrent hyper-proliferative skin disease which is often associated with free radical generation, abnormal lipid metabolism and increased inflammatory secretion that induce cardiovascular risk in these patients. The present study was intended to evaluate serum lipids, lipoprotein and oxidants-antioxidants status and to establish their relationship with atherogenic risk markers [oxidized low-density lipoprotein (oxLDL) and high-sensitivity C-reactive protein (hsCRP)] in patients with psoriasis.
   Methods: The study was conducted on 150 psoriasis patients and 150 age- and sex-matched healthy controls. Overnight fasting blood samples were obtained for lipids, lipoproteins, lipid oxidation and peroxidation products [oxLDL, malondialdehyde (MDA)], antioxidant enzymes [reduced glutathione (GSH) and total antioxidant status] levels and hsCRP estimations.
   Results: The mean levels of atherogenic lipids [total cholesterol (P < 0.001), triacylglycerol (P < 0.01)], lipid peroxidation products (P < 0.001) and oxLDL and hsCRP (P < 0.001) levels in patients with psoriasis were found to be significantly higher than those of healthy controls. On the other hand, ferric-reducing ability of plasma (FRAP, P < 0.001) and antioxidant enzyme activities (reduced GSH, P < 0.01) were significantly lower when compared to healthy controls. The plasma oxLDL was positively correlated to LDL cholesterol (P < 0.001) and MDA (P < 0.001) and negatively associated with antioxidant status in these patients. Serum MDA, FRAP and oxLDL were correlated with risk of atherosclerosis in the patients with psoriasis; however, no significant association was found between reduced GSH and hsCRP.
   Interpretation & conclusions: The study results suggest that LDL oxidation and reactive oxygen species in addition to inflammatory markers may play a pivotal role in inducing atherosclerosis in patients of psoriasis.
C1 [Asha, Kumari; Sharma, Suman Bala] Univ Delhi, Univ Coll Med Sci, Dept Biochem, Delhi, India.
   [Singal, Archana] Univ Delhi, Univ Coll Med Sci, Dept Dermatol, Delhi, India.
   [Arora, Vinod Kumar] Univ Delhi, Univ Coll Med Sci, Dept Pathol, Delhi, India.
   [Aggarwal, Amitesh] Univ Delhi, Univ Coll Med Sci, Dept Med, Delhi, India.
C3 University of Delhi; University College of Medical Sciences; University
   of Delhi; University College of Medical Sciences; University of Delhi;
   University College of Medical Sciences; University of Delhi; University
   College of Medical Sciences
RP Singal, A (corresponding author), Univ Coll Med Sci, Dept Dermatol, Delhi 110095, India.
EM archanasingal@hotmail.com
RI aggarwal, amitesh/E-4493-2011; , Kumari/S-4024-2016
OI , Kumari/0000-0003-4677-0425
FU University Grants Commission, New Delhi, India; Indian Council of
   Medical Research, New Delhi, India
FX The study was supported by funding received from University Grants
   Commission, New Delhi, India and senior research fellowship (SRF) to the
   first author (KA) from Indian Council of Medical Research, New Delhi,
   India.
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NR 31
TC 38
Z9 42
U1 0
U2 2
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, 400059, INDIA
SN 0971-5916
J9 INDIAN J MED RES
JI Indian J. Med. Res.
PD DEC
PY 2017
VL 146
BP 708
EP 713
DI 10.4103/ijmr.IJMR_717_16
PG 6
WC Immunology; Medicine, General & Internal; Medicine, Research &
   Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; General & Internal Medicine; Research & Experimental
   Medicine
GA GE5JA
UT WOS:000431256500007
PM 29664028
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Hatch, GE
   Crissman, K
   Schmid, J
   Richards, JE
   Ward, WO
   Schladweiler, MC
   Ledbetter, AD
   Kodavanti, UP
AF Hatch, Gary E.
   Crissman, Kay
   Schmid, Judy
   Richards, Judy E.
   Ward, William O.
   Schladweiler, Mette C.
   Ledbetter, Allen D.
   Kodavanti, Urmila P.
TI Strain differences in antioxidants in rat models of cardiovascular
   disease exposed to ozone
SO INHALATION TOXICOLOGY
LA English
DT Article
DE Cardiovascular disease models; lung antioxidants; oxidative stress;
   ozone; rat models
ID BRONCHOALVEOLAR LAVAGE FLUID; OXIDATIVE STRESS; ASCORBIC-ACID;
   URIC-ACID; GUINEA-PIGS; INFLAMMATION; GLUTATHIONE; HUMANS; RESTRICTION;
   KINETICS
AB We examined the hypothesis that antioxidant substances and enzymes in lung, heart and in bronchoalveolar lavage fluid (BALF) are altered in response to O-3 in cardiovascular disease and/or metabolic syndrome (CVD)-prone rat models. CVD strains [spontaneously hypertensive (SH), SH stroke-prone (SHSP), SHHF/Mcc heart failure obese (SHHF), insulin-resistant JCR:LA-cp obese (JCR) and Fawn-Hooded hypertensive (FHH)] were compared with normal strains [Wistar, Sprague-Dawley (SD) and Wistar Kyoto (WKY)]. Total glutathione (GSH+GSSG or GSx), reduced ascorbate (AH2), uric acid (UA) and antioxidant enzymes were determined in lung, heart and BALF immediately (0h) or 20-h post 4-h nose-only exposure to 0.0, 0.25, 0.5 and 1.0ppm O-3. Basal- and O-3-induced antioxidant substances in tissues varied widely among strains. Wistar rats had a robust O-3-induced increase in GSx and AH2 in the lung. Two CVD strains (JCR and SHHF) had high basal levels of AH2 and GSx in BALF as well as high basal lung UA. Across all strains, high BALF GSx was only observed when high BALF AH2 was present. CVD rats tended to respond less to O-3 than normal. High-basal BALF AH2 levels were associated with decreased O-3 toxicity. In summary, large differences were observed between both normal and CVD rat strains in low-molecular weight antioxidant concentrations in lung, BALF and heart tissue. Wistar (normal) and JCR and SHHF (CVD) rats appeared to stand out as peculiar in terms of basal- or O-3-induced changes. Results elucidate interactions among antioxidants and air pollutants that could enhance understanding of cardiopulmonary disease.
C1 [Hatch, Gary E.; Crissman, Kay; Richards, Judy E.; Schladweiler, Mette C.; Ledbetter, Allen D.; Kodavanti, Urmila P.] US EPA, Environm Publ Hlth Div, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA.
   [Schmid, Judy; Ward, William O.] US EPA, Res Cores Unit, Natl Hlth & Environm Effects Res Lab, Res Triangle Pk, NC 27711 USA.
C3 United States Environmental Protection Agency; United States
   Environmental Protection Agency
RP Kodavanti, UP (corresponding author), US EPA, Res Cores Unit, Natl Hlth & Environm Effects Res Lab, Mail Drop 105-02, Res Triangle Pk, NC 27711 USA.
EM kodavanti.urmila@epa.gov
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NR 35
TC 11
Z9 13
U1 0
U2 4
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 0895-8378
EI 1091-7691
J9 INHAL TOXICOL
JI Inhal. Toxicol.
PD MAR 20
PY 2015
VL 27
SU 1
SI SI
BP 54
EP 62
DI 10.3109/08958378.2014.954170
PG 9
WC Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Toxicology
GA CY7PX
UT WOS:000366601900006
PM 26667331
DA 2025-06-11
ER

PT J
AU Cervellati, C
   Bonaccorsi, G
   Cremonini, E
   Romani, A
   Castaldini, C
   Ferrazzini, S
   Giganti, M
   Fila, E
   Massari, L
   Bergamini, CM
AF Cervellati, Carlo
   Bonaccorsi, Gloria
   Cremonini, Eleonora
   Romani, Arianna
   Castaldini, Cristina
   Ferrazzini, Stefania
   Giganti, Melchiorre
   Fila, Enrica
   Massari, Leo
   Bergamini, Carlo M.
TI Waist circumference and dual-energy X-ray absorptiometry measures of
   overall and central obesity are similarly associated with systemic
   oxidative stress in women
SO SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION
LA English
DT Article
DE Antioxidants; body mass index; reactive oxygen species; lipid
   peroxidation; obesity
ID CORONARY-HEART-DISEASE; BODY-MASS-INDEX; POSTMENOPAUSAL WOMEN; ABDOMINAL
   ADIPOSITY; METABOLIC SYNDROME; RISK-FACTORS; FAT; INFLAMMATION;
   MENOPAUSE; MARKERS
AB Growing evidence suggests that overall and abdominal obesity might lead to oxidative stress (OxS), which, in turn, plays a key role in the pathogenesis of a wide spectrum of diseases. In this study, for the first time, we compared the correlations of indirect, i.e. anthropometric, and direct, by dual energy X-ray absorptiometry (DXA), measures of body fat with circulatory OxS markers in women. To address this issue, we assessed central and total body fat mass (FM) by DXA, and serum levels of advanced oxidation protein products (AOPP), thiols and hydroperoxides in 275 healthy women (age 21-65 years; body mass index [BMI] 21.1-32.0 kg/m(2); waist circumference [WC] 60.1-109.9 cm). Among the markers considered in the study, only hydroperoxides levels, i.e. by-products of lipid peroxidation, were significantly (p < 0.05 for all) and positively correlated to body fat accumulation after controlling for confounding factors. In particular, this marker was found to be similarly associated with DXA-derived total FM, total FM % and trunk FM as well as with WC. Of note, hydroperoxides appeared to be correlated with abdominal but not with general obesity, as classified according to standard WC and BMI cut-offs, respectively. In conclusion, taken together our data demonstrated that, at least in women, the measurement of body FM by DXA has no advantage over the simpler and cheaper WC with regard to their associations with systemic OxS markers. Moreover, WC emerged as a superior potential predictor of OxS compared to the other most commonly used anthropometric measures (including BMI and waist to hip ratio).
C1 [Cervellati, Carlo; Cremonini, Eleonora; Romani, Arianna; Bergamini, Carlo M.] Univ Ferrara, Dept Biomed & Specialist Surg Sci, Sect Med Biochem Mol Biol & Genet, I-44121 Ferrara, Italy.
   [Bonaccorsi, Gloria; Castaldini, Cristina; Ferrazzini, Stefania; Giganti, Melchiorre; Fila, Enrica; Massari, Leo] Univ Ferrara, Menopause & Osteoporosis Ctr, Dept Morphol Surg & Expt Med, I-44121 Ferrara, Italy.
   [Massari, Leo] Univ Ferrara, Sect Orthopaed Clin, Dept Morphol Surg & Expt Med, I-44121 Ferrara, Italy.
   [Giganti, Melchiorre] Univ Ferrara, Nucl Med Lab, Dept Morphol Surg & Expt Med, I-44121 Ferrara, Italy.
C3 University of Ferrara; University of Ferrara; University of Ferrara;
   University of Ferrara
RP Cervellati, C (corresponding author), Univ Ferrara, Dept Biomed & Specialist Surg Sci, Sect Med Biochem Mol Biol & Genet, I-44121 Ferrara, Italy.
EM crvcrl@unife.it
RI Bergamini, Carlo/AAW-6958-2020; BONACCORSI, GLORIA/AAC-6164-2022;
   Massari, Leo/I-1965-2019; Cervellati, Carlo/K-6453-2015; Romani,
   Arianna/AAY-2434-2021; Carlo, Bergamini/K-5664-2016
OI Massari, Leo/0000-0001-6198-2122; Cervellati, Carlo/0000-0003-4777-6300;
   BONACCORSI, GLORIA/0000-0001-5005-0274; Romani,
   Arianna/0000-0001-8000-6178; Carlo, Bergamini/0000-0002-9430-8625
FU "Local Research Project" grant from University of Ferrara, Italy
FX The study was supported by "Local Research Project" grant from
   University of Ferrara, Italy.
CR Ackermann D, 2011, NUTR RES, V31, P197, DOI 10.1016/j.nutres.2011.02.004
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NR 32
TC 10
Z9 10
U1 0
U2 5
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 0036-5513
EI 1502-7686
J9 SCAND J CLIN LAB INV
JI Scand. J. Clin. Lab. Invest.
PD MAR
PY 2014
VL 74
IS 2
BP 102
EP 107
DI 10.3109/00365513.2013.860618
PG 6
WC Medical Laboratory Technology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology; Research & Experimental Medicine
GA AF5EV
UT WOS:000334737700004
PM 24304466
DA 2025-06-11
ER

PT J
AU Santana, DF
   Ferreira, DS
   Braz, GRF
   Sousa, SMS
   Silva, TLD
   Gomes, DA
   Fernandes, MP
   Andrade-da-Costa, BL
   Lagranha, CJ
AF Santana, David F.
   Ferreira, Diorginis S.
   Braz, Glauber Ruda F.
   Sousa, Shirley M. S.
   de Araujo Silva, Tercya Lucidi
   Gomes, Dayane Aparecida
   Fernandes, Mariana P.
   Andrade-da-Costa, Belmira Lara
   Lagranha, Claudia J.
TI Maternal Protein Restriction in Two Successive Generations Impairs
   Mitochondrial Electron Coupling in the Progeny's Brainstem of
   Wistar Rats From Both Sexes
SO FRONTIERS IN NEUROSCIENCE
LA English
DT Article
DE mitochondria; intergenerational; low-protein diet; brainstem; gender;
   rats
ID ROSTRAL VENTROLATERAL MEDULLA; OXIDATIVE STRESS; ENDOTHELIAL
   DYSFUNCTION; NUTRIENT RESTRICTION; METABOLIC SYNDROME; NERVOUS-SYSTEM;
   BLOOD-PRESSURE; DIET; PHOSPHORYLATION; HYPERTENSION
AB Maternal protein deficiency during the critical development period of the progeny disturbs mitochondrial metabolism in the brainstem, which increases the risk of developing cardiovascular diseases in the first-generation (F1) offspring, but is unknown if this effect persists in the second-generation (F2) offspring. The study tested whether mitochondrial health and oxidative balance will be restored in F2 rats. Male and female rats were divided into six groups according to the diet fed to their mothers throughout gestation and lactation periods. These groups were: (1) normoprotein (NP) and (2) low-protein (LP) rats of the first filial generation (F1-NP and F1-LP, respectively) and (3) NP and (4) LP rats of the second filial generation (F2-NP and F2-LP, respectively). After weaning, all groups received commercial chow and a portion of each group was sacrificed on the 30th day of life for determination of mitochondrial and oxidative parameters. The remaining portion of the F1 group was mated at adulthood and fed an NP or LP diet during the periods of gestation and lactation, to produce progeny belonging to (5) F2R-NP and (6) F2R-LP group, respectively. Our results demonstrated that male F1-LP rats suffered mitochondrial impairment associated with an 89% higher production of reactive species (RS) and 137% higher oxidative stress biomarkers, but that the oxidative stress was blunted in female F1-LP animals despite the antioxidant impairment. In the second generation following F0 malnutrition, brainstem antioxidant defenses were restored in the F2-LP group of both sexes. However, F2R-LP offspring, exposed to LP in the diets of the two preceding generations displayed a RS overproduction with a concomitant decrease in mitochondrial bioenergetics. Our findings demonstrate that nutritional stress during the reproductive life of the mother can negatively affect mitochondrial metabolism and oxidative balance in the brainstem of F1 progeny, but that restoration of a normal diet during the reproductive life of those individuals leads toward a mitochondrial recovery in their own (F2) progeny. Otherwise, if protein deprivation is continued from the F0 generation and into the F1 generation, the F2 progeny will exhibit no recovery, but instead will remain vulnerable to further oxidative damage.
C1 [Santana, David F.; Braz, Glauber Ruda F.; Sousa, Shirley M. S.; de Araujo Silva, Tercya Lucidi; Gomes, Dayane Aparecida; Andrade-da-Costa, Belmira Lara; Lagranha, Claudia J.] Univ Fed Pernambuco, Grad Program Neurosci & Behav, Recife, PE, Brazil.
   [Ferreira, Diorginis S.] Fed Univ Sao Francisco Valley, Colegiado Educ Fis, Petrolina, Brazil.
   [Gomes, Dayane Aparecida; Andrade-da-Costa, Belmira Lara] Univ Fed Pernambuco, Ctr Ciencias Biol, Dept Fisiol & Farmacol, Recife, PE, Brazil.
   [Fernandes, Mariana P.] Univ Fed Pernambuco, Grad Program Nutr Phys Act & Phenotyp Plastic, Acad Ctr Vitoria, Vitoria De Santo Antao, Brazil.
   [Fernandes, Mariana P.; Lagranha, Claudia J.] Univ Fed Pernambuco, Nucleo Educ Fis & Ciencias Esporte, Ctr Acad Vitoria, Recife, PE, Brazil.
C3 Universidade Federal de Pernambuco; Universidade Federal do Vale do Sao
   Francisco; Universidade Federal de Pernambuco; Universidade Federal de
   Pernambuco; Universidade Federal de Pernambuco
RP Lagranha, CJ (corresponding author), Univ Fed Pernambuco, Grad Program Neurosci & Behav, Recife, PE, Brazil.; Lagranha, CJ (corresponding author), Univ Fed Pernambuco, Nucleo Educ Fis & Ciencias Esporte, Ctr Acad Vitoria, Recife, PE, Brazil.
EM lagranha@hotmail.com
RI Braz, Glauber/D-4811-2016; Fernandes, Mariana/S-2099-2018
OI Lagranha, Claudia/0000-0001-6883-9476
FU Fundacao de Amparo a Ciencia e Tecnologia do Estado de Pernambuco [APQ
   026.4-09/12, APQ-0164-4.05/15]
FX We would like to thank the professor Dr. Donald F. Selliti for the
   English editing and the grammatical revision, and Severina C. Andrade
   Silva for the animal care. We also thank the Fundacao de Amparo a
   Ciencia e Tecnologia do Estado de Pernambuco by funding this work,
   Grant/Award Number: APQ 026.4-09/12 and APQ-0164-4.05/15.
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NR 75
TC 6
Z9 6
U1 0
U2 2
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1662-453X
J9 FRONT NEUROSCI-SWITZ
JI Front. Neurosci.
PD MAR 14
PY 2019
VL 13
AR 203
DI 10.3389/fnins.2019.00203
PG 14
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA HO7OV
UT WOS:000461137900001
PM 30930735
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Qin, YH
   Yan, GL
   Qiao, Y
   Ma, CL
   Liu, JH
   Tang, CC
AF Qin, Yuhan
   Yan, Gaoliang
   Qiao, Yong
   Ma, Changle
   Liu, Juchuan
   Tang, Chengchun
TI Relationship between Random Blood Glucose, Fasting Blood Glucose, and
   Gensini Score in Patients with Acute Myocardial Infarction
SO BIOMED RESEARCH INTERNATIONAL
LA English
DT Article
ID TYPE-2 DIABETES-MELLITUS; CORONARY-HEART-DISEASE;
   CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; RISK; MORTALITY;
   HYPERGLYCEMIA; SYSTEM
AB Objective. To examine the relationship between admission random blood glucose (RBG), fasting blood glucose (FBG), and Gensini score in patients with acute myocardial infarction (AMI) to clarify the effects of RBG and FBG on the severity of coronary artery disease. Method. A total of 958 consecutive AMI patients who underwent emergency coronary angiography at the Cardiology Department of Zhongda Hospital (affiliated with Southeast University) were enrolled in this study from January 1, 2016, to December 31, 2018. The Gensini score of each patient was calculated according to the results of coronary angiography. The RBG, FBG, baseline data, hematological indexes, echocardiography parameters, coronary angiography data, and the use of intra-aortic balloon pump (IABP) were recorded. Patients with an RBG level >11.1 mmol/L were classified into the stress hyperglycemia group, and those with an FBG level >7.0 mmol/L were classified into the elevated FBG group. The Gensini scores in the stress hyperglycemia and elevated FBG groups were compared to those in the control group, and correlations between the RBG and FBG levels and the Gensini scores of AMI patients were evaluated. Independent risk factors for the Gensini score were analyzed by multiple linear and multiple logistic regression analyses. Results. The Gensini scores of the stress hyperglycemia group and the elevated FBG group were higher than those of the control group. RBG and FBG were positively correlated with the Gensini score, and there were significant differences between RBG and FBG in different Gensini score groups. After adjusting for confounding factors, multiple linear regression analysis showed that sex, diabetes, estimated glomerular filtration rate (eGFR), and FBG were independent risk factors for the Gensini score. Multiple logistic regression analysis showed that age and FBG were independent risk factors in group 2 compared to group 1, eGFR and FBG were independent risk factors in group 3, and eGFR and FBG were independent risk factors in group 4. Diabetes and RBG were not independent risk factors for the Gensini score. Conclusion. The Gensini scores of patients in the stress hyperglycemia group and the elevated FBG group were significantly higher than those in the control group. RBG and FBG were positively correlated with the Gensini score in AMI patients, and FBG was an independent risk factor for the Gensini score in AMI patients.
C1 [Qin, Yuhan; Ma, Changle; Liu, Juchuan] Southeast Univ, Med Sch, Nanjing 210009, Jiangsu, Peoples R China.
   [Yan, Gaoliang; Qiao, Yong; Tang, Chengchun] Southeast Univ, Zhongda Hosp, Dept Cardiol, Nanjing 210009, Jiangsu, Peoples R China.
C3 Southeast University - China; Southeast University - China
RP Tang, CC (corresponding author), Southeast Univ, Zhongda Hosp, Dept Cardiol, Nanjing 210009, Jiangsu, Peoples R China.
EM tangchengchun@hotmail.com
FU National Natural Science Foundation of China [81600227]
FX The research was funded by the National Natural Science Foundation of
   China (grant no. 81600227).
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NR 36
TC 18
Z9 19
U1 1
U2 12
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2314-6133
EI 2314-6141
J9 BIOMED RES INT
JI Biomed Res. Int.
PD OCT 15
PY 2019
VL 2019
AR 9707513
DI 10.1155/2019/9707513
PG 9
WC Biotechnology & Applied Microbiology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Research & Experimental Medicine
GA JH7MW
UT WOS:000492953100006
PM 31737681
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Bircher, L
   Schwab, C
   Geirnaert, A
   Greppi, A
   Lacroix, C
AF Bircher, Lea
   Schwab, Clarissa
   Geirnaert, Annelies
   Greppi, Anna
   Lacroix, Christophe
TI Planktonic and Sessile Artificial Colonic Microbiota Harbor Distinct
   Composition and Reestablish Differently upon Frozen and Freeze-Dried
   Long-Term Storage
SO MSYSTEMS
LA English
DT Article
DE FMT; bacterial lifestyle; colonic microbiota; cryopreservation;
   lyophilization
ID COMPLETE GENOME SEQUENCE; HUMAN GUT MICROBIOTA; FECAL MICROBIOTA; GEN.
   NOV.; FERMENTATION; BACTERIA; BUTYRATE; BIOFILM; MODEL; FECES
AB Biofilm-associated, sessile communities represent the major bacterial lifestyle, whereas planktonic cells mainly appear during initial colonization of new surfaces. Previous research, mainly performed with pathogens, demonstrated increased environmental stress tolerance of biofilm-growing compared to planktonic bacteria. The lifestyle-specific stress response of colonic microbiota, both natural and fermentation produced, has not been addressed before. Planktonic and sessile "artificial" colonic microbiota delivered by PolyFermS continuous fermentation models can provide a controllable and reproducible alternative to fecal transplantation in treating gastrointestinal disorders. We therefore characterized planktonic and sessile microbiota produced in two PolyFermS models inoculated with immobilized fecal microbiota and comparatively tested their levels of tolerance of frozen storage (-80 degrees C) and freeze-dried storage (4 degrees C) for 9 months to mimic preservation strategies for therapeutic applications. Sessile microbiota harbored next to shared taxa a unique community distinguishable from planktonic microbiota. Synergistetes and Proteobacteria were highly represented in sessile microbiota, while Firmicutes were more abundant in planktonic microbiota. The community structure and metabolic activity of both microbiota, monitored during standardized reactivation batch fermentations, were better preserved after frozen storage than dried storage, indicated by higher Bray-Curtis similarity and enhanced recovery of metabolite production. For both lifestyles, reestablishment of Bacteroidaceoe was impaired after frozen and dried storage along with reduced propionate formation. In contrast, butyrate production was maintained after reactivation despite compositional rearrangements within the butyrate-producing community. Unexpectedly, the rate of recovery of metabolite production was lower after preservation of sessile than planktonic microbiota. We speculate that higher functional dependencies between microbes might have led to the lower stress tolerance of sessile than planktonic microbiota.
   IMPORTANCE Fecal microbiota transplantation has been successfully applied in the treatment of recurrent Clostridium difflcile infection and has been suggested as an alternative therapy for other intestinal disorders such as inflammatory bowel disease or metabolic syndrome. "Artificial" colonic microbiota delivered by PolyFermS continuous fermentation models can provide a controllable and reproducible alternative to fecal transplantation, but effective preservation strategies must be developed. In this study, we systematically investigated the response of sessile and planktonic artificial colonic microbiota to cryopreservation and lyophilization. We suggest that functional redundancy is an important factor in providing functional stability with respect to exposure to stress during processing and storage. Functional redundancy in compositionally reduced microbial systems may be considered when designing microbial products for therapy.
C1 [Bircher, Lea; Schwab, Clarissa; Geirnaert, Annelies; Greppi, Anna; Lacroix, Christophe] Swiss Fed Inst Technol, Lab Food Biotechnol, Inst Food Nutr & Hlth, Zurich, Switzerland.
C3 Swiss Federal Institutes of Technology Domain; ETH Zurich
RP Lacroix, C (corresponding author), Swiss Fed Inst Technol, Lab Food Biotechnol, Inst Food Nutr & Hlth, Zurich, Switzerland.
EM christophe.lacroix@hest.ethz.ch
RI Greppi, Anna/AAB-9537-2020; Schwab, Clarissa/AGL-7943-2022; Geirnaert,
   Annelies/E-3857-2019; Lacroix, Christophe/B-5139-2016
OI GREPPI, Anna/0000-0003-4249-3950; Geirnaert,
   Annelies/0000-0002-3390-6701; Lacroix, Christophe/0000-0003-4360-2020
FU Swiss National Science Foundation (Bern, Switzerland) [35150]; ETH
   Zurich [ETHIRA 39 13-2]
FX We thank Alfonso Die and Barbara Albrecht for experimental assistance.
   We acknowledge the support of the Genetic Diversity Centre (GDC; ETH
   Zurich) for providing support for sequencing analyses.This study was by
   supported by a research grant of the Swiss National Science Foundation
   (project number 35150, Bern, Switzerland) and an ETH Zurich research
   grant (ETHIRA 39 13-2).
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NR 80
TC 8
Z9 9
U1 0
U2 1
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 2379-5077
J9 MSYSTEMS
JI mSystems
PD JAN-FEB
PY 2020
VL 5
IS 1
AR e00521-19
DI 10.1128/mSystems.00521-19
PG 18
WC Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Microbiology
GA KT2OI
UT WOS:000518855000006
PM 31964766
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Marei, WFA
   Van den Bosch, L
   Pintelon, I
   Mohey-Elsaeed, O
   Bols, PEJ
   Leroy, JLMR
AF Marei, Waleed F. A.
   Van den Bosch, Lotte
   Pintelon, Isabel
   Mohey-Elsaeed, Omnia
   Bols, Peter E. J.
   Leroy, Jo L. M. R.
TI Mitochondria-targeted therapy rescues development and quality of embryos
   derived from oocytes matured under oxidative stress conditions: a bovine
   in vitro mode
SO HUMAN REPRODUCTION
LA English
DT Article
DE oocyte quality; infertility; lipotoxicity; MitoQ; antioxidants
ID ENDOPLASMIC-RETICULUM STRESS; HUMAN FOLLICULAR-FLUID; METABOLIC
   SYNDROME; FATTY-ACIDS; OBESITY; ANTIOXIDANT; DYSFUNCTION; IMPACT;
   VIABILITY; CAPACITY
AB STUDY QUESTION: Can we use a mitochondrial-targeted antioxidant (Mitoquinone) during in vitro embryo culture to rescue developmental competence of oocytes matured under lipotoxic conditions, exhibiting mitochondria! dysfunction and oxidative stress?
   SUMMARY ANSWER: Supplementation of embryo culture media with Mitoquinone reduced oxidative stress and prevented mitochondria! uncoupling in embryos derived from metabolically compromised oocytes in vitro, leading to higher blastocyst rates and lower blastomeric apoptosis.
   WHAT IS KNOWN ALREADY: Maternal metabolic disorders, such as obesity and type-II diabetes are associated with hyperlipidemia and elevated free fatty acid (FFA) concentrations in the ovarian follicular fluid (FF). Oocyte maturation under these lipotoxic conditions results in increased oxidative stress levels, mitochondrial dysfunction, reduced developmental competence and disappointing IVF results.
   STUDY DESIGN, SIZE, DURATION: A well-described bovine oocyte IVM model was used, where a pathophysiologically relevant elevated FF concentrations of palmitic acid (PA; 150 mu M or 300 mu M) were added to induce oxidative stress. After fertilization (Day 0, DO), zygotes were in vitro cultured (IVC, from D1to D8) in standard fatty acid-free media in the presence or absence of Mitoquinone or its carrier triphenylphosphonium.
   PARTICIPANTS/MATERIALS, SETTING, METHODS: Embryo cleavage and fragmentation (D2) and blastocyst rates (D8) were recorded. Mitochondrial activity and oxidative stress in cleaved embryos at D2 were determined using specific fluorogenic probes and confocal microscopy. D8 blastocysts were used to (i) examine the expression of marker genes related to mitochondrial unfolded protein responses (UPRmt ; HSPD1 and HSPE1), mitochondrial biogenesis (TFAM), endoplasmic reticulum (ER) UPR (ATF4, ATF6 and BiP) and oxidative stress (CAT, GPX1 and SOD2) using real time RT-PCR; (ii) determine cell differentiation and apoptosis using CDX-2 and cleaved caspase-3 immunostaining; and (iii) measure mtDNA copy numbers. This was tested in a series of experiments with at least three independent replicates for each, using a total of 2525 oocytes. Differences were considered significant if a P value was <0.05 after Bonferroni correction.
   MAIN RESULTS AND THE ROLE OF CHANCE: Exposure to PA during IVM followed by culture under control conditions resulted in a significant increase in oxidative stress in embryos at D2. This was associated with a significant reduction in mitochondrial inner membrane potential (uncoupling) compared with solvent control (P < 0.05). The magnitude of these effects was PA-concentration dependent. Consequently, development to the blastocysts stage was significantly hampered. Surviving blastocysts exhibited high apoptotic cell indices and upregulated mRNA expression indicating persistent oxidative stress, mitochondria! and ER UPRs. In contrast, supplementation zygotes with Mitoquinone during IVC (i) prevented mitochondria' uncoupling and alleviated oxidative stress at D2; and (ii) rescued blastocyst quality; normalized oxidative stress and UPR related genes and apoptotic cell indices (P > 0.01 compared with solvent control). Mitoquinone also improved blastocyst rate in PA-exposed groups, an effect that was dependent on PA concentration.
   LARGE SCALE DATA: N/A
   LIMITATIONS, REASONS FOR CAUTION: This is a fundamental study performed using a bovine in vitro model using PA-induced lipotoxicity during oocyte maturation. PA is the most predominant FFA in the FF that is known to induce lipotoxicity; however, in vivo maturation in patients suffering from maternal metabolic disorders involve more factors that cannot be represented in one model. Nevertheless, focusing on the carryover oxidative stress as a known key factor affecting developmental competence, and considering the novel beneficial rescuing effects of Mitoquinone shown here, we believe this model is of high biological relevance.
   WIDER IMPLICATIONS OF THE FINDINGS: Human oocytes collected for IVF treatments from patients with maternal metabolic disorders are vulnerable to lipotoxicity and oxidative stress during in vivo maturation. The results shown here suggest that mitochondria? targeted therapy, such as using Mitoquinone, during IVC may rescue the developmental competence and quality of these compromised oocytes. After further clinical trials, this may be a valuable approach to increase IVF success rates for infertile patients experiencing metabolic disorders.
C1 [Marei, Waleed F. A.; Van den Bosch, Lotte; Bols, Peter E. J.; Leroy, Jo L. M. R.] Univ Antwerp, Dept Vet Sci, Gamete Res Ctr, B-2610 Antwerp, Belgium.
   [Marei, Waleed F. A.] Cairo Univ, Fac Vet Med, Dept Theriogenol, Giza 12211, Egypt.
   [Pintelon, Isabel; Mohey-Elsaeed, Omnia] Univ Antwerp, Lab Cell Biol & Histol, B-2610 Antwerp, Belgium.
   [Mohey-Elsaeed, Omnia] Cairo Univ, Fac Vet Med, Dept Cytol & Histol, Giza 12211, Egypt.
C3 University of Antwerp; Egyptian Knowledge Bank (EKB); Cairo University;
   University of Antwerp; Egyptian Knowledge Bank (EKB); Cairo University
RP Marei, WFA (corresponding author), Univ Antwerp, Dept Vet Sci, Gamete Res Ctr, B-2610 Antwerp, Belgium.
EM waleed.marei@uantwerpen.be
RI Leroy, Jo/AAC-1791-2020; Marei, Waleed/P-1081-2016; Pintelon,
   Isabel/JTU-0950-2023
OI Bols, Peter/0000-0003-0432-8719; Marei, Waleed/0000-0002-8498-8903
FU University of Antwerp, Belgium (BOF/KP) [34399]; Research
   Foundation-Flanders (FWO) Antwerp, Belgium [12I1417N]; Hercules
   Foundation of the Flemish Government (Hercules grant) [AUHA.15.12]
FX University of Antwerp, Belgium (BOF/KP grant number 34399); Research
   Foundation-Flanders (FWO, postdoctoral fellowship, grant number
   12I1417N) Antwerp, Belgium. The Leica SP 8 confocal microscope used in
   this study was funded by the Hercules Foundation of the Flemish
   Government (Hercules grant AUHA.15.12).
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NR 69
TC 56
Z9 60
U1 1
U2 27
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0268-1161
EI 1460-2350
J9 HUM REPROD
JI Hum. Reprod.
PD OCT
PY 2019
VL 34
IS 10
BP 1984
EP 1998
DI 10.1093/humrep/dez161
PG 15
WC Obstetrics & Gynecology; Reproductive Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology; Reproductive Biology
GA JI5DB
UT WOS:000493485900015
PM 31625574
OA Bronze
DA 2025-06-11
ER

PT J
AU Viltart, O
   Vanbesien-Mailliot, CCA
AF Viltart, Odile
   Vanbesien-Mailliot, Christel C. A.
TI Impact of prenatal stress on neuroendocrine programming
SO THESCIENTIFICWORLDJOURNAL
LA English
DT Review
DE adaptation; central nervous system; developmental windows; environment;
   evolution; feto-placental unit; gestational stress; glucocorticoid;
   growth; homeostasis; hypothalamo-pituitary-adrenal axis; immune
   function; imprinting; maternal care; metabolic syndrome; mood disorders;
   neuroimmunoendocrinology; obesity; plasticity; programming; sexual
   behavior; stress; sympathetic nervous system
ID PITUITARY-ADRENAL AXIS; CORTICOTROPIN-RELEASING HORMONE; RECEPTOR
   MESSENGER-RNA; GROWTH-FACTOR-I; SEXUALLY DIMORPHIC NUCLEUS; CATCH-UP
   GROWTH; ADULT MALE RATS; HIPPOCAMPAL CORTICOSTEROID RECEPTORS;
   ENVIRONMENTAL ENRICHMENT REVERSES; LONG-TERM CONSEQUENCES
AB Since life emerged on the Earth, the development of efficient strategies to cope with sudden and/or permanent changes of the environment has been virtually the unique goal pursued by every organism in order to ensure its survival and thus perpetuate the species. In this view, evolution has selected tightly regulated processes aimed at maintaining stability among internal parameters despite external changes, a process termed homeostasis. Such an internal equilibrium relies quite heavily on three interrelated physiological systems: the nervous, immune, and endocrine systems, which function as a permanently activated watching network, communicating by the mean of specialized molecules: neurotransmitters, cytokines, and hormones or neurohormones. Potential threats to homeostasis might occur as early as during in utero life, potentially leaving a lasting mark on the developing organism. Indeed, environmental factors exert early-life influences on the structural and functional development of individuals, giving rise to changes that can persist throughout life. This organizational phenomenon, encompassing prenatal environmental events, altered fetal growth, and development of long-term pathophysiology, has been named early-life programming. Over the past decade, increased scientific activities have been devoted to deciphering the obvious link between states of maternal stress and the behavioral, cognitive, emotional, and physiological reactivity of the progeny. This growing interest has been driven by the discovery of a tight relationship between prenatal stress and development of short- and long-term health disorders. Among factors susceptible of contributing to such a deleterious programming, nutrients and hormones, especially steroid hormones, are considered as powerful mediators of the fetal organization since they readily cross the placental barrier. In particular, variations in circulating maternal glucocorticoids are known to impact this programming strongly, notably when hormonal surges occur during sensitive periods of development, so-called developmental windows of vulnerability. Stressful events occurring during the perinatal period may impinge on various aspects of the neuroendocrine programming, subsequently amending the offspring's growth, metabolism, sexual maturation, stress responses, and immune system. Such prenatal stress-induced modifications of the phenotypic plasticity of the progeny might ultimately result in the development of long-term diseases, from metabolic syndromes to psychiatric disorders. Yet, we would like to consider the outcome of this neuroendocrine programming from an evolutionary perspective. Early stressful events during gestation might indeed shape internal parameters of the developing organisms in order to adapt the progeny to its everyday environment and thus contribute to an increased reproductive success, or fitness, of the species. Moreover, parental care, adoption, or enriched environments after birth have been shown to reverse negative long-term consequences of a disturbed gestational environment. In this view, considering the higher potential for neonatal plasticity within the brain in human beings as compared to other species, long-term consequences of prenatal stress might not be as inexorable as suggested in animal-based studies published to date.
C1 Inst Pasteur, Nueroimmunoendocrinol Lab, F-59019 Lille, France.
   Univ Lille 2, Sch Med, EA2683 MENRT, F-59045 Lille, France.
   Univ Lille 1, UPRES EA 4052, Dept Adapt Neurosci & Physiol, F-59655 Villeneuve Dascq, France.
C3 Pasteur Network; Universite de Lille; Institut Pasteur Lille; Universite
   de Lille; CHU Lille; Universite de Lille
RP Viltart, O (corresponding author), Inst Pasteur, Nueroimmunoendocrinol Lab, F-59019 Lille, France.
EM odile.viltart@univ-lille1.fr; Christel.Vanbesien@univ-lille1.fr
OI VANBESIEN-MAILLIOT, Christel/0000-0003-3693-9418; VILTART,
   Odile/0000-0002-4801-3586
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NR 379
TC 60
Z9 72
U1 0
U2 40
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1537-744X
J9 THESCIENTIFICWORLDJO
JI TheScientificWorldJOURNAL
PY 2007
VL 7
BP 1493
EP 1537
DI 10.1100/tsw.2007.204
PG 45
WC Environmental Sciences; Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Science & Technology - Other Topics
GA 210BY
UT WOS:000249432900017
PM 17767365
OA Green Submitted, gold, Green Published
DA 2025-06-11
ER

PT J
AU Shikov, AN
   Pozharitskaya, ON
   Makarov, VG
AF Shikov, Alexander N.
   Pozharitskaya, Olga N.
   Makarov, Valery G.
TI Aralia elata var. mandshurica (Rupr. & Maxim.) J.Wen: An
   overview of pharmacological studies
SO PHYTOMEDICINE
LA English
DT Article
DE Aralia; Adaptogen; Clinical data; Pharmacology; Toxicity
ID NF-KAPPA-B; CENTRAL-NERVOUS-SYSTEM; ELATOSIDE C PROTECTS; MIQ SEEM
   TASAES; OLEANOLIC ACID; ROOT BARK; ISCHEMIA-REPERFUSION; TRITERPENE
   SAPONINS; BIOACTIVE SAPONINS; ETHANOL ABSORPTION
AB Purpose: Aralia elata var. mandshurica (Rupr. & Maxim.) J.Wen syn. A. mandshurica Rupr. & Maxim is evaluated for its medicinal application. The aim of this study is to analyze pharmacological studies on A. data var. mandshurica published until December 2015.
   Methods: The information regarding the chemistry, safety, effectiveness, and pharmacological and clinical effects of A. elata was systematically collected from the scientific literature through library catalogs; online services such as E-library.ru, Medline/PubMed, Scopus, Web of Science, and Google Scholar.
   Results: A. elata is often considered an example of a medicinal plant used in Chinese, Korean, and Japanese traditional medicine. However, the contemporary applications of Aralia in officinal medicine result primarily from a large number of pharmacological and clinical investigations carried out in the former USSR in the mid-20th century. Since the 1950s, medicinal preparations from radices of A. elata and radices of A. mandshurica have secured an established position within Russian/USSR medicine as evidenced by the inclusion of the drug in recent editions of the National Pharmacopoeia of the USSR and in the Register of Medicinal Preparations of Russia. Pharmacological studies on animals have shown that Aralia increases physical working capacity and affords a stress-protective effect against a broad spectrum of harmful factors including cold stress, immobilization, UV irradiation, and low air pressure. The phytoadaptogen exerts an effect on the central nervous, reproductive, immune, respiratory, and gastrointestinal systems; the metabolic syndrome including hypolipidemic and antidiabetic effects; and blood coagulation. Together with general properties of adaptogens, Aralia has its own specificity, which manifests in cardioprotective and antiarrhythmic activities. Studies on isolated organs, cells, and enzymes have revealed that Aralia preparations exhibit antioxidant activities and enhance sarcoplasmic reticulum Ca2+-ATPase activity, inhibit endoplasmic reticulum stress-associated apoptosis markers (GRP78, CHOP, Caspase-12, and JNK), and increase phosphorylation of STAT3 and Bc12/Bax ratio; they also show cytotoxic activities against some tumor cell lines; affect NF-kappa B and PPARs activities; and regulate biosynthesis of pro-inflammatory cytokines and inflammation-related protein expression, tissue respiration, and oxygen consumption. In healthy subjects, Aralia increases mental performance, working capacity, and endurance of movement. Numerous clinical trials have shown the efficiency of Aralia preparations in. patients with traumatic brain injury (accompanied with asthenic syndrome and neurotic reactions, depression, neurasthenia, and psychasthenia), neurological diseases (accompanied with astheno-depressive and astheno-hypochondriasis syndromes), myasthenia syndrome (accompanied with chronic post-influenza arachnoiditis), and arterial hypotension. Aralia tincture and "Saparal" are useful as antiviral remedies. Radioprotective properties of Aralia have been reported in pregnant women. Synergistic antiobesity effect was reported for the combination of A. mandshurica and Engelhardtia chrysolepfs extracts and antidiabetic effect for the combination of Aralia and glipizide.
   Promising stress-relieving effects of Aralia are reported for professionals whose work requires a high level of attention. Its proposed ability to moderate stress-induced damage and dysfunction in the cardiovascular tissue might make Aralia the adaptogen of choice among patients with higher risk for cardiovascular diseases. Because Aralia extract administration appears to affect plasma glucose level and hepatic lipid accumulation and ameliorate hyperinsulinemia, it might also provide benefits and be the adaptogen of choice for patients with obesity and diabetes.
   Conclusion: This review describes the considerable diversity of pharmacological effects of A. elata reported in numerous studies carried out in the former USSR and other countries, which have been confirmed over >47 years of use of the plant as an official medicinal remedy. The knowledge discussed in this review can be applied to the expansion of the use of this high-value plant in the pharmacotherapy of European and other countries and for the further discovery of new drugs based on the secondary metabolites of this plant. Modern approaches in mechanisms of action, including a study of gene expression profiling, suggest the most up-to-date challenges for the future research of Aralia. (C) 2016 Elsevier GmbH. All rights reserved.
C1 [Shikov, Alexander N.; Pozharitskaya, Olga N.; Makarov, Valery G.] St Petersburg Inst Pharm, P 245, Vsevolozhsky Dist 188663, Kuzmolovo, Russia.
RP Shikov, AN (corresponding author), St Petersburg Inst Pharm, P 245, Vsevolozhsky Dist 188663, Kuzmolovo, Russia.
EM spb.pharmacy@gmail.com
RI Makarov, Valery/F-8746-2016; Pozharitskaya, Olga/D-9671-2014; Shikov,
   Alexander/B-1804-2008
OI Pozharitskaya, Olga/0000-0003-1061-0665; Shikov,
   Alexander/0000-0003-4351-0695
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NR 100
TC 39
Z9 44
U1 2
U2 58
PU ELSEVIER GMBH
PI MUNICH
PA HACKERBRUCKE 6, 80335 MUNICH, GERMANY
SN 0944-7113
EI 1618-095X
J9 PHYTOMEDICINE
JI Phytomedicine
PD NOV 15
PY 2016
VL 23
IS 12
BP 1409
EP 1421
DI 10.1016/j.phymed.2016.07.011
PG 13
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA EB2KZ
UT WOS:000387192300016
PM 27765361
DA 2025-06-11
ER

PT J
AU Bakris, GL
   Fonseca, V
   Katholi, RE
   McGill, JB
   Messerli, FH
   Phillips, RA
   Raskin, P
   Wright, JT
   Oakes, R
   Lukas, MA
   Anderson, KM
   Bell, DSH
AF Bakris, GL
   Fonseca, V
   Katholi, RE
   McGill, JB
   Messerli, FH
   Phillips, RA
   Raskin, P
   Wright, JT
   Oakes, R
   Lukas, MA
   Anderson, KM
   Bell, DSH
CA GEMINI Investigators
TI Metabolic effects of carvedilol vs metoprolol in patients with type 2
   diabetes mellitus and hypertension - A randomized controlled trial
SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
LA English
DT Article
ID CONVERTING-ENZYME-INHIBITION; CARDIOVASCULAR MORTALITY; BLOOD-PRESSURE;
   ANTIHYPERTENSIVE DRUGS; OXIDATIVE STRESS; LIPID-METABOLISM;
   RISK-FACTORS; DISEASE; MICROALBUMINURIA; INTERVENTION
AB Context beta-Blockers have been shown to decrease cardiovascular risk in patients with hypertension and type 2 diabetes mellitus (DM); however, some components of the metabolic syndrome are worsened by some beta-blockers.
   Objective To compare the effects of beta-blockers with different pharmacological profiles on glycemic and metabolic control in participants with DM and hypertension receiving renin-angiotensin system (RAS) blockade, in the context of cardiovascular risk factors.
   Design, Setting, and Participants A randomized, double-blind, parallel-group trial (The Glycemic Effects in Diabetes Mellitus: Carvedilol-Metoprolol Comparison in Hypertensives [GEMINI]) conducted between June 1, 2001, and April 6, 2004, at 205 US sites that compared the effects of carvedilol and metoprolol tartrate on glycemic control. The 1235 participants were aged 36 to 85 years with hypertension (>130/80 mm Hg) and type 2 DM (glycosylated hemoglobin [HbA(1c)], 6.5%-8.5%) and were receiving RAS blockers. Participants were followed up for 35 weeks.
   Interventions Participants were randomized to receive a 6.25- to 25-mg dose of carvedilol (n=498)or 50- to 200-mg dose of metoprolol tartrate (n=737),each twice daily. open-label hydrochlorothiazide and a dihydropyridine calcium antagonist were added, if needed, to achieve blood pressure target.
   Main Outcome Measures Difference between groups in mean change from baseline HbA(1c) following 5 months of maintenance therapy. Additional prespecified comparisons included change from baseline HbA(1c) in individual treatment groups, treatment effect on insulin sensitivity, and microalbuminuria.
   Results The 2 groups differed in mean change in HbA(1c) from baseline (0.13%; 95% confidence interval [CI],-0.22% to-0.04%; P=.004; modified intention-to-treat analysis). The mean (SD) HbA(1c) increased with metoprolol (0.15% [0.04%]; P<.001) but not carvedilol (0.02% [0.04%]; P=.65). Insulin sensitivity improved with carvedilol (-9.1%; P=.004) but not metoprolol (-2.0%; P=.48); the between-group difference was -7.2% (95% CI, -13.8% to -0.2%; P=.004). Blood pressure was similar between groups. Progression to microalbuminuria was less frequent with carvedilol than with metoprolol (6.4% vs 10.3%; odds ratio, 0.60; 95% CI, 0.36-0.97; P=.04).
   Conclusions Both beta-blockers were well tolerated; use of carvedilol in the presence of RAS blockade did not affect glycemic control and improved some components of the metabolic syndrome relative to metoprolol in participants with DM and hypertension. The effects of the 2 beta-blockers on clinical outcomes need to be compared in long-term clinical trials.
C1 Univ Alabama Birmingham, Birmingham, AL 35294 USA.
   Rush Univ, Med Ctr, Dept Prevent Med, Chicago, IL USA.
   Tulane Univ, Dept Med, New Orleans, LA 70118 USA.
   St Johns Hosp, Dept Med, Springfield, IL USA.
   Washington Univ, Sch Med, Dept Med, St Louis, MO 63110 USA.
   St Lukes Roosevelt Hosp, Dept Med, New York, NY 10025 USA.
   Mt Sinai Sch Med, Dept Med, New York, NY USA.
   Univ Texas, SW Med Ctr, Dept Med, Dallas, TX USA.
   Univ Hosp Cleveland, Dept Med, Cleveland, OH 44106 USA.
   Louis Stokes Cleveland Dept Vet Affairs Med Ctr, Dept Med, Cleveland, OH USA.
   GlaxoSmithKline, Philadelphia, PA USA.
   Univ Alabama Birmingham, Dept Med, Birmingham, AL 35294 USA.
C3 University of Alabama System; University of Alabama Birmingham; Rush
   University; Tulane University; Washington University (WUSTL); Mount
   Sinai St. Luke's; Mount Sinai West; Icahn School of Medicine at Mount
   Sinai; University of Texas System; University of Texas Southwestern
   Medical Center Dallas; University of Texas Dallas; University Hospitals
   of Cleveland; University System of Ohio; Case Western Reserve
   University; US Department of Veterans Affairs; Veterans Health
   Administration (VHA); Louis Stokes Cleveland Veterans Affairs Medical
   Center; GlaxoSmithKline; Glaxosmithkline USA; University of Alabama
   System; University of Alabama Birmingham
RP Univ Alabama Birmingham, Room 702,Fac Off Tower 510,20th St S, Birmingham, AL 35294 USA.
EM dshbell@uab.edu
RI Messerli, Franz/AAR-4783-2021; Butko, Olena/HDN-3484-2022
OI Katholi, Richard/0000-0002-5625-7417; Patt,
   Mitchell/0000-0001-9696-4477; ROTHBERG, AMY/0000-0002-0243-9135
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NR 38
TC 600
Z9 648
U1 2
U2 21
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 0098-7484
EI 1538-3598
J9 JAMA-J AM MED ASSOC
JI JAMA-J. Am. Med. Assoc.
PD NOV 10
PY 2004
VL 292
IS 18
BP 2227
EP 2236
DI 10.1001/jama.292.18.2227
PG 10
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 870PK
UT WOS:000225070000023
PM 15536109
DA 2025-06-11
ER

PT J
AU Pereira, ENGD
   Paula, DP
   de Araujo, BP
   da Fonseca, MDM
   Diniz, MDHS
   Daliry, A
   Griep, RH
AF Goulart da Silva Pereira, Evelyn Nunes
   Paula, Daniela Polessa
   de Araujo, Beatriz Peres
   Mendes da Fonseca, Maria de Jesus
   Haueisen Sander Diniz, Maria de Fatima
   Daliry, Anissa
   Griep, Rosane Harter
TI Advanced glycation end product: A potential biomarker for risk
   stratification of non-alcoholic fatty liver disease in ELSA-Brasil study
SO WORLD JOURNAL OF GASTROENTEROLOGY
LA English
DT Article
DE Advanced glycation end products; Non-alcoholic fatty liver disease;
   Steatosis; ELSA-Brasil study; Spectroscopy
ID DIAGNOSTIC-ACCURACY; METABOLIC SYNDROME; OXIDATIVE STRESS; ELEVATED
   LEVELS; SERUM; N-EPSILON-(CARBOXYMETHYL)LYSINE; ULTRASONOGRAPHY;
   EPIDEMIOLOGY; PATHOGENESIS; PROGRESSION
AB BACKGROUND
   Liver diseases are associated with the excess formation of advanced glycation end products (AGEs), which induce tissue inflammation and oxidative damage. However, the trend of oxidative marker levels according to the steatosis grade in non-alcoholic fatty liver disease (NAFLD) is unclear.
   AIM
   To compare serum AGE levels between participants with NAFLD accordingly to steatosis severity in the baseline ELSA-Brasil population.
   METHODS
   In 305 individuals at baseline ELSA-Brasil, NAFLD-associated steatosis was classified by ultrasound hepatic attenuation. The participants were grouped according to the severity of steatosis: mild and moderate/severe pooled. The measurement of serum fluorescent AGE concentrations was based on spectrofluorimetric detection. Serum AGE content and clinical and laboratory characteristics of the participants were compared between groups. The correlation between serum AGE levels and the grade of steatosis was analyzed. Logistic regression analysis was used to investigate the relationship between serum AGE levels and steatosis severity. A P value < 0.05 was considered statistically significant.
   RESULTS
   According to the steatosis severity spectrum in NAFLD, from mild to moderate/severe, individuals with the most severe steatosis grade had a higher incidence of metabolic syndrome (63% vs 34%, P <= 0.001), diabetes mellitus (37% vs 14%, P <= 0.001), and high cholesterol levels (51% vs 33%, P < 0.001). Moreover, individuals with increasing severity of steatosis presented increasing waist circumference, body mass index, systolic and diastolic blood pressure, fasting blood glucose, glycated hemoglobin, insulin, triglycerides, alanine aminotransferase, gamma-glutamyl transferase, C-reactive protein, and uric acid levels and lower high-density lipoprotein. Higher serum AGE content was present in the moderate/severe group of individuals than in the mild group (P = 0.008). In addition, the serum AGE levels were correlated with the steatosis grade in the overall sample (rho = 0.146, P = 0.010). Logistic regression analysis, after adjusting for confounding variables, showed that subjects with higher serum AGE content had a 4.6-fold increased chance of having moderate or severe steatosis when compared to low levels of serum AGEs. According to the results of the receiver operator characteristic curves analyses (areas under the curve, AUC = 0.83), AGEs could be a good marker of steatosis severity in patients with NAFLD and might be a potential biomarker in predicting NAFLD progression, strengthening the involvement of AGE in NAFLD pathogenesis.
   CONCLUSION
   NAFLD-associated steatosis was associated with serum AGE levels; therefore, plasmatic fluorescent AGE quantification by spectroscopy could be a promising alternative method to monitor progression from mild to severe NAFLD accordingly to steatosis grade.
C1 [Goulart da Silva Pereira, Evelyn Nunes; de Araujo, Beatriz Peres; Daliry, Anissa] Fundacao Oswaldo Cruz, Lab Cardiovasc Invest, BR-21040360 Manguinho, RJ, Brazil.
   [Paula, Daniela Polessa] Brazilian Inst Geog & Stat, Natl Sch Stat Sci, BR-20231050 Rio De Janeiro, Brazil.
   [Mendes da Fonseca, Maria de Jesus] Fundacao Oswaldo Cruz, Dept Epidemiol & Quantitat Methods Hlth, BR-21040360 Rio De Janeiro, Brazil.
   [Haueisen Sander Diniz, Maria de Fatima] Univ Fed Minas Gerais, Fac Med, BR-31270901 Belo Horizonte, MG, Brazil.
   [Griep, Rosane Harter] Fundacao Oswaldo Cruz, Lab Hlth & Environm Educ, BR-21040360 Rio De Janeiro, Brazil.
C3 Fundacao Oswaldo Cruz; Escola Nacional de Ciencias Estatisticas (ENCE);
   Fundacao Oswaldo Cruz; Universidade Federal de Minas Gerais; Fundacao
   Oswaldo Cruz
RP Daliry, A (corresponding author), Fundacao Oswaldo Cruz, Lab Cardiovasc Invest, BR-21040360 Manguinho, RJ, Brazil.
EM daliry@ioc.fiocruz.br
RI Daliry, Anissa/F-6256-2014; Fonseca, Maria/HTR-3788-2023; Griep,
   Rosane/ABB-4509-2020; Nunes Goulart da Silva Pereira,
   Evelyn/AAG-2711-2021
OI Daliry, Anissa/0000-0001-7303-0030; Nunes Goulart da Silva Pereira,
   Evelyn/0000-0001-5511-7036; Polessa Paula, Daniela/0000-0002-0576-7361
FU Brazilian Ministry of Health (Science and Technology Department);
   Brazilian Ministry of Science and Technology (Financiadora de Estudos e
   Projetos and CNPq National Research Council) [01 06 0010.00 RS, 01 06
   0300.00 ES, 01 06 0212.00 BA, 01 06 0278.00 MG, 01 06 0115.00 SP, 01 06
   0071.00 RJ]; Conselho Nacional de Desenvolvimento Cientifico e
   Tecnologico (CNPq); Carlos Chagas Filho Rio de Janeiro State Research
   Support Foundation (FAPERJ)
FX Supported by Brazilian Ministry of Health (Science and Technology
   Department) and the Brazilian Ministry of Science and Technology
   (Financiadora de Estudos e Projetos and CNPq National Research Council),
   No. 01 06 0010.00 RS, No. 01 06 0300.00 ES, No. 01 06 0212.00 BA, No. 01
   06 0278.00 MG, No. 01 06 0115.00 SP, and No. 01 06 0071.00 RJ; and
   Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) and
   the Carlos Chagas Filho Rio de Janeiro State Research Support Foundation
   (FAPERJ) (to Griep RH).
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NR 79
TC 19
Z9 19
U1 0
U2 3
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 7041 Koll Center Parkway, Suite 160, PLEASANTON, CA, UNITED STATES
SN 1007-9327
EI 2219-2840
J9 WORLD J GASTROENTERO
JI World J. Gastroenterol.
PD AUG 7
PY 2021
VL 27
IS 29
BP 4913
EP 4928
DI 10.3748/wjg.v27.i29.4913
PG 16
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA UJ2AZ
UT WOS:000691096200012
PM 34447235
OA Green Published, hybrid
DA 2025-06-11
ER

PT S
AU Fehm, HL
   Kern, W
   Peters, A
AF Fehm, H. L.
   Kern, W.
   Peters, A.
BE Kalsbeek, A
   Fliers, E
   Hofman, MA
   Swaab, DF
   VanSomeren, EJW
   Buijs, RM
TI The selfish brain: competition for energy resources
SO HYPOTHALAMIC INTEGRATION OF ENERGY METABOLISM
SE PROGRESS IN BRAIN RESEARCH
LA English
DT Article; Proceedings Paper
CT 24th International Summer School of Brain Research
CY AUG 29-SEP 01, 2005
CL Royal Netherlands Acad Arts & Sci, Amsterdam, NETHERLANDS
SP Elsevier, Ferring BV, Grad Sch Neurosci Amsterdam, Hersenstichting Nederland, Merck Res Labs, Nederlandse Vereniging Endocrinologie, Nuclilab, Numico Res BV, NV Organon, Solvay Pharmaceut BV, Stichting Diabet Fonds Nederland, Stichting CH VandenHoutenfonds, ZonMw
HO Royal Netherlands Acad Arts & Sci
ID LONG-TERM POTENTIATION; FOOD-INTAKE; HYPOGLYCEMIA UNAWARENESS;
   HYPOTHALAMIC NEURONS; NERVOUS-SYSTEM; BODY-FAT; INSULIN; GLUCOSE;
   OBESITY; WEIGHT
AB Although the brain constitutes only 2% of the body mass, its metabolism accounts for 50% of total body glucose utilization. This delicate situation is aggravated by the fact that the brain depends on glucose as energy substrate. Thus, the contour of a major problem becomes evident: how can the brain maintain constant fluxes of large amounts of glucose to itself in the presence of powerful competitors as fat and muscle tissue.
   Activity of cortical neurons generates an "energy on demand" signal which eventually mediates the uptake of glucose from brain capillaries. Because energy stores in the circulation (equivalent to ca. 5 g glucose) are also limited, a second signal is required termed "energy on request"; this signal is responsible for the activation of allocation processes. The term "allocation" refers to the activation of the "behavior control column" by an input from the hippocampus-amygdala system. As far as eating behavior is concerned the behavior control column consists of the ventral medial hypothalamus (VMH) and periventricular nucleus (PVN). The PVN represents the central nucleus of the brain's stress systems, the hypothalamus-pituitary-adrenal (HPA) axis and the sympathetic nervous system (SNS). Activation of the sympatico-adrenal system inhibits glucose uptake by peripheral tissues by inhibiting insulin release and inducing insulin resistance and increases hepatic glucose production. With an inadequate "energy on request" signal neuroglucopenia would be the consequence. A decrease in brain glucose can activate glucose-sensitive neurons in the lateral hypothalamus (LH) with the release of orexigenic peptides which stimulate food intake. If the energy supply of the brain depends on activation of the LH rather than on increased allocation to the brain, an increase in body weight is evitable. An increase in fat mass will generate feedback signals as leptin and insulin, which activate the arcuate nucleus. Activation of arcuate nucleus in turn will stimulate the activity of the PVN in a way similar to the activation by the hippocampus-amydala system.
   The activity of PVN is influenced by the hippocampal outflow which in turn is the consequence of a balance of low-affinity and high-affinity glucocorticoid receptors. This set-point can permanently be displaced by extreme stress situations, by starvation, exercise, hormones, drugs or by endocrine-disrupting chemicals. Disorders in the "energy on request" process will influence the allocation of energy and in so doing alter the body mass of the organism. In this "selfish brain theory" the neocortex and the limbic system play a central role in the pathogenesis of diseases, such as anorexia nervosa, obesity and diabetes mellitus type II.
   From these considerations it appears that the primary disturbance in obesity is a displacement of the hippocampal set-point of the system. The resulting permanent activation of the feedback system must result in a likewise permanent activation of the sympatico-adrenal system, which induces insulin resistance, hypertension and the other components of the metabolic syndrome. Available therapies for treatment of the metabolic syndrome (blockade of alpha- and beta-adrenergic receptors, insulin and insulin secretagogues) interfere with mechanisms, which must be considered compensatory. This explains why these therapies are disappointing in the long run. New therapeutic strategies based on the "selfish brain theory" will be discussed.
C1 Univ Lubeck, Med Klin 1, D-23538 Lubeck, Germany.
C3 University of Lubeck
RP Fehm, HL (corresponding author), Univ Lubeck, Med Klin 1, Ratzeburger Allee 160, D-23538 Lubeck, Germany.
EM fehm@uni-luebeck.de
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NR 42
TC 120
Z9 139
U1 0
U2 28
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA SARA BURGERHARTSTRAAT 25, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0079-6123
BN 0-444-52261-1
J9 PROG BRAIN RES
PY 2006
VL 153
BP 129
EP 140
DI 10.1016/S0079-6123(06)53007-9
PG 12
WC Endocrinology & Metabolism; Neurosciences
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology
GA BFB37
UT WOS:000240722300007
PM 16876572
DA 2025-06-11
ER

PT J
AU Di Monaco, A
   Bruno, I
   Sestito, A
   Lamendola, P
   Barone, L
   Bagnato, A
   Nerla, R
   Pisanello, C
   Giordano, A
   Lanza, GA
   Crea, F
AF Di Monaco, A.
   Bruno, I.
   Sestito, A.
   Lamendola, P.
   Barone, L.
   Bagnato, A.
   Nerla, R.
   Pisanello, C.
   Giordano, A.
   Lanza, G. A.
   Crea, F.
TI Cardiac adrenergic nerve function and microvascular dysfunction in
   patients with cardiac syndrome X
SO HEART
LA English
DT Article
ID CARDIOVASCULAR MAGNETIC-RESONANCE; CORONARY BLOOD-FLOW; ANGINA-PECTORIS;
   MYOCARDIAL-PERFUSION; MECHANISMS; HEART; ISCHEMIA; RESERVE; STRESS; LINK
AB Objective: To assess whether abnormalities in cardiac uptake of I-123-metaiodobenzylguanidine (MIBG) correlate with coronary microvascular dysfunction in patients with cardiac syndrome X (CSX).
   Setting: University hospital.
   Patients: 29 patients (aged 59 (SD 7) years, 11 men) with typical CSX and a matched group of 20 healthy subjects (aged 56 (7) years, 8 men) were studied.
   Interventions: Planar and single photon emission computed tomography (SPECT) MIBG myocardial scintigraphy was performed in all subjects. Coronary flow response (CFR) to adenosine and to cold pressor test (CPT) in the left anterior descending (LAD) coronary artery was assessed in all CSX patients and in 12 controls by transthoracic Doppler echocardiography.
   Main outcome measures: Abnormalities in cardiac MIBG scintigraphy were observed in 25 CSX patients (86.2%), but in no healthy control (p < 0.001). Compared to controls, CSX patients showed a lower heart/mediastinum (H/M) ratio of MIBG uptake (1.69 (0.24) vs 2.2 (0.3), p < 0.001) and a higher cardiac MIBG defect score (25 (22) vs 4 (2), p = 0.002). Both CFR to adenosine (3.31 (1.1) vs 1.94 (0.6), p < 0.001) and CFR to CPT (2.35 (0.5) vs 1.63 (0.4), p < 0.001) were lower in CSX patients than in controls. In CSX patients, however, no correlation was found between MIBG H/M ratio and CFR to adenosine (r = 0.17; p = 0.38) and to CPT (r = -0.28; p = 0.13), as well as between MIBG uptake score in the LAD territory and CFR to adenosine (r = 0.14; p = 0.47) and to CPT (r = 0.06; p = 0.73).
   Conclusion: Our data show striking abnormalities in cardiac adrenergic nerve function and in coronary microvascular function in CSX patients. However, no significant relation between the two abnormalities was found. Further studies are needed to clarify the mechanisms and the role of MIBG defects in CSX patients.
C1 [Di Monaco, A.; Sestito, A.; Lamendola, P.; Barone, L.; Nerla, R.; Pisanello, C.; Lanza, G. A.; Crea, F.] Univ Cattolica Sacro Cuore, Ist Cardiol, I-00168 Rome, Italy.
   [Bruno, I.; Giordano, A.] Univ Cattolica Sacro Cuore, Ist Med Nucl, I-00168 Rome, Italy.
   [Bagnato, A.] Azienda Osped, Unita Operat Med Nucl, Cosenza, Italy.
C3 Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli;
   Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli;
   Azienda Ospedaliera di Cosenza
RP Lanza, GA (corresponding author), Univ Cattolica Sacro Cuore, Ist Cardiol, Largo A Gemelli 8, I-00168 Rome, Italy.
EM g.a.lanza@inwind.it
RI BArone, Lucy/JFS-7992-2023; Lanza, Gaetano/AAC-2660-2019; Crea,
   Filippo/AAC-9754-2022; Nerla, Roberto/AAL-1534-2020; Giordano,
   Alessandro/AAW-9921-2021; Di monaco, Antonio/AAR-8825-2021
OI Nerla, Roberto/0000-0002-9065-3261; Barone, Lucy/0000-0001-9476-9168;
   Giordano, Alessandro/0000-0002-6978-0880; Di monaco,
   Antonio/0000-0002-1297-2056
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NR 29
TC 16
Z9 18
U1 0
U2 0
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 1355-6037
EI 1468-201X
J9 HEART
JI Heart
PD APR
PY 2009
VL 95
IS 7
BP 550
EP 554
DI 10.1136/hrt.2008.156851
PG 5
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 419CE
UT WOS:000264195900008
PM 19164330
DA 2025-06-11
ER

PT J
AU Long, CA
   Timmins, LH
   Koutakis, P
   Goodchild, TT
   Lefer, DJ
   Pipinos, II
   Casale, GP
   Brewster, LP
AF Long, Chandler A.
   Timmins, Lucas H.
   Koutakis, Panagiotis
   Goodchild, Traci T.
   Lefer, David J.
   Pipinos, Iraklis I.
   Casale, George P.
   Brewster, Luke P.
TI An endovascular model of ischemic myopathy from peripheral arterial
   disease
SO JOURNAL OF VASCULAR SURGERY
LA English
DT Article; Proceedings Paper
CT 40th Annual Meeting of the Southern-Association-for-Vascular-Surgery
CY JAN 20-23, 2016
CL Cancun, MEXICO
SP So Assoc Vasc Surg
ID CRITICAL LIMB ISCHEMIA; PORCINE MODEL; LOWER-EXTREMITY; DOUBLE-BLIND;
   METABOLIC SYNDROME; CELLULAR THERAPY; STROMAL CELLS; MUSCLE;
   ARTERIOGENESIS; GROWTH
AB Objective: Peripheral arterial disease (PAD) is a significant age-related medical condition with limited pharmacologic options. Severe PAD, termed critical limb ischemia, can lead to amputation. Skeletal muscle is the end organ most affected by PAD, leading to ischemic myopathy and debility of the patient. Currently, there are not any therapeutics to treat ischemic myopathy, and proposed biologic agents have not been optimized owing to a lack of preclinical models of PAD. Because a large animal model of ischemic myopathy may be useful in defining the optimal dosing and delivery regimens, the objective was to create and to characterize a swine model of ischemic myopathy that mimics patients with severe PAD.
   Methods: Yorkshire swine (N = 8) underwent acute right hindlimb ischemia by endovascular occlusion of the external iliac artery. The effect of ischemia on limb function, perfusion, and degree of ischemic myopathy was quantified by weekly gait analysis, arteriography, hindlimb blood pressures, femoral artery duplex ultrasound scans, and histologic examination. Animals were terminated at 5 (n = 5) and 6 (n = 3) weeks postoperatively. Ossabaw swine (N = 8) fed a high-fat diet were used as a model of metabolic syndrome for comparison of arteriogenic recovery and validation of ischemic myopathy.
   Results: There was persistent ischemia in the right hindlimb, and occlusion pressures were significantly depressed compared with the untreated left hindlimb out to 6 weeks (systolic blood pressure, 31 +/- 21 vs 83 +/- 15 mm Hg, respectively; P = .0007). The blood pressure reduction resulted in a significant increase of ischemic myopathy in the gastrocnemius muscle in the treated limb. Gait analysis revealed a functional deficit of the right hindlimb immediately after occlusion that improved rapidly during the first 2 weeks. Peak systolic velocity values in the right common femoral artery were severely diminished throughout the entire study (P <.001), and the hemodynamic environment after occlusion was characterized by low and oscillatory wall shear stress. Finally, the internal iliac artery on the side of the ischemic limb underwent significant arteriogenic remodeling (1.8 x baseline) in the Yorkshire but not in the Ossabaw swine model.
   Conclusions: This model uses endovascular technology to produce the first durable large animal model of ischemic myopathy. Acutely (first 2 weeks), this model is associated with impaired gait but no tissue loss. Chronically (2-6 weeks), this model delivers persistent ischemia, resulting in ischemic myopathy similar to that seen in PAD patients. This model may be of use for testing novel therapeutics including biologic therapies for promoting neovascularization and arteriogenesis.
C1 [Long, Chandler A.; Brewster, Luke P.] Emory Univ, Sch Med, Dept Surg, Atlanta, GA 30322 USA.
   [Timmins, Lucas H.] Emory Univ, Sch Med, Dept Radiol & Imaging Sci, Atlanta, GA 30322 USA.
   [Koutakis, Panagiotis; Pipinos, Iraklis I.; Casale, George P.] Univ Nebraska, Med Ctr, Omaha, NE USA.
   [Goodchild, Traci T.; Lefer, David J.] Louisiana State Univ, Sch Med, Cardiovasc Ctr Excellence, New Orleans, LA USA.
   [Brewster, Luke P.] Atlanta VA Med Ctr, Surg & Res Serv, Atlanta, GA USA.
C3 Emory University; Emory University; University of Nebraska System;
   University of Nebraska Medical Center; Louisiana State University
   System; US Department of Veterans Affairs; Veterans Health
   Administration (VHA); Atlanta VA Health Care System; Atlanta VA Medical
   Center
RP Brewster, LP (corresponding author), Div Vasc Surg, Woodruff Mem Bldg,101 Woodruff Circle,Ste 5105, Atlanta, GA 30322 USA.
EM lbrewst@emory.edu
RI Chen, Jerry/KMX-1547-2024; Lefer, David/A-6372-2012
OI Koutakis, Panagiotis/0000-0002-8352-5667; Lefer,
   David/0000-0003-2293-7278; Pipinos, Iraklis/0000-0001-6873-6346
FU Emory/Georgia Institute of Technology Regenerative Engineering and
   Medicine; PHS Grant from the Clinical and Translational Science Award
   Program, National Institutes of Health, National Center for Advancing
   Translational Sciences [UL1TR000454]; NHLBI [KO8HL119592]; Society for
   Vascular Surgery/American College of Surgeons Scientific Development
   Grant; American Heart Award Innovative Research Grant [IRG14740001];
   Emory Department of Surgery Startup Funds
FX Funding was provided by Emory/Georgia Institute of Technology
   Regenerative Engineering and Medicine (L.P.B.), which is supported in
   part by PHS Grant UL1TR000454 from the Clinical and Translational
   Science Award Program, National Institutes of Health, National Center
   for Advancing Translational Sciences; NHLBI KO8HL119592 and Society for
   Vascular Surgery/American College of Surgeons Scientific Development
   Grant (L.P.B.); American Heart Award Innovative Research Grant
   IRG14740001 (L.P.B.); and Emory Department of Surgery Startup Funds
   (L.P.B.).
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NR 46
TC 21
Z9 27
U1 0
U2 8
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0741-5214
J9 J VASC SURG
JI J. Vasc. Surg.
PD SEP
PY 2017
VL 66
IS 3
BP 891
EP 901
DI 10.1016/j.jvs.2016.07.127
PG 11
WC Surgery; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Surgery; Cardiovascular System & Cardiology
GA FJ2LQ
UT WOS:000412559500117
PM 27693032
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Jacome-Sosa, MM
   Lu, J
   Wang, Y
   Ruth, MR
   Wright, DC
   Reaney, MJ
   Shen, JH
   Field, CJ
   Vine, DF
   Proctor, SD
AF Jacome-Sosa, M. Miriam
   Lu, Jing
   Wang, Ye
   Ruth, Megan R.
   Wright, David C.
   Reaney, Martin J.
   Shen, Jianheng
   Field, Catherine J.
   Vine, Donna F.
   Proctor, Spencer D.
TI Increased hypolipidemic benefits of cis-9, trans-11
   conjugated linoleic acid in combination with trans-11 vaccenic
   acid in a rodent model of the metabolic syndrome, the JCR:LA-cp
   rat
SO NUTRITION & METABOLISM
LA English
DT Article
ID INSULIN-RESISTANCE; FATTY-ACIDS; MITOCHONDRIAL BIOGENESIS;
   CARDIOVASCULAR-DISEASE; GLUCOSE-TOLERANCE; REACTIVE PROTEIN; OXIDATIVE
   STRESS; SKELETAL-MUSCLE; ADIPOSE-TISSUE; PLASMA-LIPIDS
AB Background: Conjugated linoleic acid (cis-9, trans-11 CLA) and trans-11 vaccenic acid (VA) are found naturally in ruminant-derived foods. CLA has been shown to have numerous potential health related effects and has been extensively investigated. More recently, we have shown that VA has lipid-lowering properties associated with reduced hepatic lipidogenesis and chylomicron secretion in the JCR:LA-cp rat. The aim of this study was to evaluate potential additional hypolipidemic effects of purified forms of CLA and VA in an animal model of the metabolic syndrome (the JCR:LA-cp rat).
   Methods: Twenty four obese JCR:LA-cp rats were randomized and assigned to one of three nutritionally adequate iso-caloric diets containing 1% w/w cholesterol and 15% w/w fat for 16 wk: 1) control diet (CD), 2) 1.0% w/w cis-9, trans-11 CLA (CLA), 3) 1.0% w/w VA and 1% w/w cis-9, trans-11 CLA (VA+CLA). Lean rats were fed the CD to represent normolipidemic conditions.
   Results: Fasting plasma triglyceride (TG), total cholesterol and LDL-cholesterol concentrations were reduced in obese rats fed either the CLA diet or the VA+CLA diet as compared to the obese control group (p < 0.05, p < 0.001; p < 0.001, p < 0.01; p < 0.01, p < 0.001, respectively). The VA+CLA diet reduced plasma TG and LDL-cholesterol to the level of the normolipidemic lean rats and further decreased nonesterified fatty acids compared to the CLA diet alone. Interestingly, rats fed the VA+CLA diet had a higher food intake but lower body weight than the CLA fed group (P < 0.05). Liver weight and TG content were lower in rats fed either CLA (p < 0.05) or VA +CLA diets (p < 0.001) compared to obese control, consistent with a decreased relative protein abundance of hepatic acetyl-CoA carboxylase in both treatment groups (P < 0.01). The activity of citrate synthase was increased in liver and adipose tissue of rats fed, CLA and VA+CLA diets (p < 0.001) compared to obese control, suggesting increased mitochondrial fatty acid oxidative capacity.
   Conclusion: We demonstrate that the hypolipidemic effects of chronic cis-9, trans-11 CLA supplementation on circulating dyslipidemia and hepatic steatosis are enhanced by the addition of VA in the JCR:LA-cp rat.
C1 [Jacome-Sosa, M. Miriam; Lu, Jing; Wang, Ye; Vine, Donna F.; Proctor, Spencer D.] Univ Alberta, Metab & Cardiovasc Dis Lab, Edmonton, AB T6G 2P5, Canada.
   [Jacome-Sosa, M. Miriam; Lu, Jing; Wang, Ye; Ruth, Megan R.; Wright, David C.; Field, Catherine J.; Vine, Donna F.; Proctor, Spencer D.] Univ Alberta, Alberta Inst Human Nutr, Edmonton, AB T6G 2P5, Canada.
   [Jacome-Sosa, M. Miriam; Lu, Jing; Wang, Ye; Ruth, Megan R.; Wright, David C.; Field, Catherine J.; Vine, Donna F.; Proctor, Spencer D.] Univ Alberta, Alberta Diabet Inst, Edmonton, AB T6G 2P5, Canada.
   [Reaney, Martin J.; Shen, Jianheng] Univ Saskatchewan, Dept Appl Microbiol & Food Sci, Saskatoon, SK S7N 5A8, Canada.
C3 University of Alberta; University of Alberta; University of Alberta;
   University of Saskatchewan
RP Proctor, SD (corresponding author), Univ Alberta, Metab & Cardiovasc Dis Lab, Edmonton, AB T6G 2P5, Canada.
EM spencer.proctor@ualberta.ca
RI Field, Craig/C-7275-2018; Proctor, Spencer/F-2774-2012
OI Proctor, Spencer/0000-0002-7597-5262; Field,
   Catherine/0000-0001-7285-4767; Wright, David/0000-0003-3867-8901
FU Dairy Farmers of Canada; Alberta Livestock Industry Development Fund;
   Natural Science and Engineering Research Council of Canada; National
   Council of Mexico for Science and Technology (CONACyT); HSFC
FX Funds for this work were supported in part by the Dairy Farmers of
   Canada, Alberta Livestock Industry Development Fund and the Natural
   Science and Engineering Research Council of Canada. MMJS is supported by
   a scholarship from the National Council of Mexico for Science and
   Technology (CONACyT). SDP is supported by a New Investigator Award from
   HSFC. The authors declare that they have no competing interests.
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NR 53
TC 36
Z9 41
U1 0
U2 15
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1743-7075
J9 NUTR METAB
JI Nutr. Metab.
PD JUL 16
PY 2010
VL 7
AR 60
DI 10.1186/1743-7075-7-60
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 658LE
UT WOS:000282490700002
PM 20633302
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Robillard, PY
   Dekker, G
   Scioscia, M
   Saito, S
AF Robillard, Pierre-Yves
   Dekker, Gustaaf
   Scioscia, Marco
   Saito, Shigeru
TI Progress in the understanding of the pathophysiology of immunologic
   maladaptation related to early-onset preeclampsia and metabolic syndrome
   related to late-onset preeclampsia
SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
LA English
DT Review
DE immunology; inositol phosphoglycan P-type; maternal-fetal graft paradox;
   placental dysfunction; preeclampsia; primipaternity; regulatory T cells
ID REGULATORY T-CELLS; NATURAL-KILLER-CELLS; NK CELLS; RISK; TOLERANCE;
   IMPLANTATION; PATHOGENESIS; EVOLUTION; MEMORY; BLOOD
AB Among mammalian species, human reproduction has 2 outstanding features. The human hemochorial placentation is characterized by a very deep endovascular trophoblast invasion in the spiral arteries, reaching deep into the myometrium. This requires an agonistic direct cell-cell interaction between the maternal immune system and semiallogeneic trophoblast. The second feature is preeclampsia, a heterogeneous syndrome, a uniquely human condition. The human female is one of the few mammals exposed to her partner's semen on multiple occasions before conception. Regulatory T cells, especially paternal antigen-specific regulatory T cells, play an important role in the maintenance of pregnancy. Sexual intercourse increases the number of dendritic cells in the uterus that play an important role in the induction of paternal antigen-specific regulatory T cells. Paternal antigen-specific regulatory T cells maintain pregnancy by inducing tolerance. In the decidua basalis of preeclamptic cases, clonal regulatory T cells are reduced; these would normally monoclonally expand to recognize fetal or paternal antigens. Programmed cell death-1 expressed on T cells regulate cytotoxic T-cell activity and protect the fetus against maternal rejection. Programmed cell death-1 expression on clonal cytotoxic T cells is reduced in preeclampsia especially in early-onset preeclampsia, making the fetus and placenta vulnerable to attack by cytotoxic T cells. These phenomena can explain the epidemiologic phenomenon that preeclampsia is more common in couples using condom contraception, with shorter cohabitation periods, first pregnancies, first pregnancies in multiparous women when they change partner, and pregnancies after assisted reproduction using donated gametes.
   In contrast to its importance in early-onset preeclampsia, shallow trophoblast invasion does not play a role in the development of preeclampsia, that is, immune maladaptation does not seem to be involved. Late-onset preeclampsia (>34 weeks' gestation), representing 80% to 90% of preeclampsia in most developed countries with a "Western lifestyle," is strongly associated with maternal cardiometabolic variables (metabolic syndrome). Although the underlying pathophysiology might be quite different, syncytiotrophoblast stress is the final common pathway leading to the maternal syndrome among the subtypes of preeclampsia by causing an imbalance between proangiogenic factors (placental growth factor and vascular endothelial growth factor) and antiangiogenic factors (soluble fms-like tyrosine kinase-1 and soluble endoglin). Low-dose aspirin, started before 16 week's gestation, will prevent up to 60% of early-onset preeclampsia but will not prevent late-onset preeclampsia. Optimizing prepregnancy weight and controlling gestational weight gain may be the most effective ways to prevent preeclampsia.
C1 [Robillard, Pierre-Yves] Ctr Hosp Univ Sud Reunion, Serv Neonatol, St Pierre, Reunion, France.
   [Robillard, Pierre-Yves] Ctr Hosp Univ Sud Reunion, Ctr Etud Perinatales Indien, St Pierre, Reunion, France.
   [Dekker, Gustaaf] Univ Adelaide, Robinson Inst, Lyell McEwin Hosp, Dept Obstet & Gynecol, Adelaide, SA, Australia.
   [Scioscia, Marco] Mater Hosp, Unit Gynecol Surg, Dept Obstet & Gynecol, Bari, Italy.
   [Saito, Shigeru] Univ Toyama, Dept Obstet & Gynecol, Toyama, Japan.
C3 CHU Reunion; CHU Reunion; Robinson Research Institute; Lyell McEwin
   Hospital; University of Adelaide; University of Toyama
RP Robillard, PY (corresponding author), Ctr Hosp Univ Sud Reunion, Serv Neonatol, St Pierre, Reunion, France.
EM robillard.reunion@wanadoo.fr
RI SAITO, SHIGERU/JXO-0004-2024; Robillard, Pierre-Yves/AAD-9774-2021
OI Dekker, Gus/0000-0002-7362-6683
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NR 71
TC 69
Z9 72
U1 2
U2 28
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0002-9378
EI 1097-6868
J9 AM J OBSTET GYNECOL
JI Am. J. Obstet. Gynecol.
PD FEB
PY 2022
VL 226
IS 2
SU S
BP S867
EP S875
DI 10.1016/j.ajog.2021.11.019
EA FEB 2022
PG 9
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA ZF5VZ
UT WOS:000759636700006
PM 35177223
OA hybrid
DA 2025-06-11
ER

PT J
AU Campisano, SE
   Echarte, SM
   Podaza, E
   Chisari, AN
AF Campisano, Sabrina Edith
   Echarte, Stella Maris
   Podaza, Enrique
   Chisari, Andrea Nancy
TI Protein malnutrition during fetal programming induces fatty liver in
   adult male offspring rats
SO JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
LA English
DT Article
DE Fetal programming; Low protein diet; Metabolic syndrome; Liver damage;
   Non-alcoholic fatty liver; Wistar rats
ID INTRAUTERINE GROWTH-RETARDATION; GAMMA-GLUTAMYL-TRANSPEPTIDASE;
   HEPATOCELLULAR-CARCINOMA; METABOLIC SYNDROME; GLUTATHIONE LEVELS;
   OXIDATIVE STRESS; DISEASE; TRANSFERASE; DAMAGE; DIET
AB We evaluated the effects of protein malnutrition on liver morphology and physiology in rats subjected to different malnutrition schemes. Pregnant rats were fed with a control diet or a low protein diet (LPD). Male offspring rats received a LPD during gestation, lactation, and until they were 60 days old (MM group), a late LPD that began after weaning (CM), or a LPD administrated only during the gestation-lactation period followed by a control diet (MC). On day 60, blood was collected and the liver was dissected out. We found a decrease in MM rats' total body (p < 0.001) and liver (p < 0.05) weight. These and CM rats showed obvious liver dysfunction reflected by the increase in serum glutamic pyruvic transaminase (SGOT) (MM p < 0.001) and serum glutamic pyruvic transaminase (SGPT) (MM and CM p < 0.001) enzymes, and liver content of cholesterol (MM and CM p < 0.001) and triglycerides (MM p < 0.01; CM p < 0.001), in addition to what we saw by histology. Liver dysfunction was also shown by the increase in gamma glutamyl transferase (GGT) (MM, MC, and CM p < 0.001) and GST-pi1 (MM and CM p < 0.001, MC p < 0.05) expression levels. MC rats showed the lowest increment in GST-pi1 expression (MC vs. MM; p < 0.001, MC vs. CM; p < 0.01). ROS production (MM, CM, and MC: p < 0.001), lipid peroxidation (MM, CM, and MC p < 0.001), content of carbonyl groups in liver proteins (MM and CM p < 0.001, MC p < 0.01), and total antioxidant capacity (MM, CM, and MC p < 0.001) were increased in the liver of all groups of malnourished animals. However, MM rats showed the highest increment. We found higher TNF-alpha (MM and CM p < 0.001), and IL-6 (MM and CM p < 0.001) serum levels and TGF-beta liver content (MM p < 0.01; CM p < 0.05), in MM and CM groups, while MC rats reverted the values to normal levels. Pro-survival signaling pathways mediated by tyrosine or serine/threonine kinases (pAKT) (MM and CM p < 0.001; MC p < 0.01) and extrasellular signal-regulated kinase (pERKs) (MM p < 0.01; CM p < 0.05) appeared to be activated in the liver of all groups of malnourished rats, suggesting the presence of cells resistant to apoptosis which would become cancerous. In conclusion, a LPD induced liver damage whose magnitude was related to the developmental stage at which malnutrition occurs and to its length.
C1 [Campisano, Sabrina Edith] Univ Nacl Mar Plata, Fac Ciencias Exactas & Nat, Dept Quim, Dean Funes 3350,B7602AYL, Buenos Aires, DF, Argentina.
   [Echarte, Stella Maris; Podaza, Enrique; Chisari, Andrea Nancy] Univ Nacl Mar Plata, Inst Invest Biol, CONICET, 4th Level Dean Funes 3250,B7602AYL, Buenos Aires, DF, Argentina.
C3 National University of Mar del Plata; National University of Mar del
   Plata; Consejo Nacional de Investigaciones Cientificas y Tecnicas
   (CONICET)
RP Chisari, AN (corresponding author), Univ Nacl Mar Plata, Inst Invest Biol, CONICET, 4th Level Dean Funes 3250,B7602AYL, Buenos Aires, DF, Argentina.
EM achisari@mdp.edu.ar
RI Podaza, Enrique/AAL-9286-2020
OI Chisari, Andrea/0000-0001-9351-0138; Podaza,
   Enrique/0000-0002-3078-9458; Echarte, Stella/0000-0001-9276-497X
FU National University of Mar del Plata
FX We specially thank Veronica Elena Gimenez for spelling and grammar
   corrections. This work was supported by grants from the National
   University of Mar del Plata. SC is a post-doctoral fellow from CONICET.
   EP and SME are doctoral fellows from CONICET. AC is a career
   investigator from CONICET.
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NR 48
TC 9
Z9 9
U1 0
U2 11
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1138-7548
EI 1877-8755
J9 J PHYSIOL BIOCHEM
JI J. Physiol. Biochem.
PD MAY
PY 2017
VL 73
IS 2
BP 275
EP 285
DI 10.1007/s13105-017-0549-1
PG 11
WC Biochemistry & Molecular Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Physiology
GA ES8ST
UT WOS:000399827900013
PM 28160259
OA Green Published
DA 2025-06-11
ER

PT J
AU Atchan, APN
   Shivashankara, ST
   Piazza, S
   Tchamgoue, AD
   Beretta, G
   Dell'Agli, M
   Magni, P
   Agbor, GA
   Kuiaté, JR
   Manjappara, UV
AF Atchan, Achille Parfait Nwakiban
   Shivashankara, Shilpa Talkad
   Piazza, Stefano
   Tchamgoue, Armelle Deutou
   Beretta, Giangiacomo
   Dell'Agli, Mario
   Magni, Paolo
   Agbor, Gabriel Agbor
   Kuiate, Jules-Roger
   Manjappara, Uma Venkateswaran
TI Polyphenol-Rich Extracts of Xylopia and Aframomum Species Show Metabolic
   Benefits by Lowering Hepatic Lipid Accumulation in Diet-Induced Obese
   Mice
SO ACS OMEGA
LA English
DT Article
ID IDENTIFICATION; TISSUES; MODEL; ASSAY
AB Metabolic syndrome is a complex condition associated with a series of pathologies featuring glucose intolerance, diabetes, high blood pressure, dyslipidemia, microalbuminuria, overweight, and obesity. It is also related to nonalcoholic fatty liver disease (NAFLD), recognized as the most familiar cause of chronic liver disease worldwide. The overall prevalence of metabolic syndrome and, consequently, the one of NAFLD is constantly increasing worldwide. The initial management of these diseases involves lifestyle modifications, including changes in diet and physical exercise. In addition to conventional drugs like orlistat, botanicals are traditionally used to counteract these disorders, and some of them are currently under evaluation. The present work evaluated the in vivo beneficial effects of hydroalcoholic extracts of two Cameroonian spices, focusing on obesity-related hepatic lipid injury in high-fat-fed C57BL/6 mice. Hydroethanolic extracts were prepared and characterized by reverse phase-high-performance liquid chromatography (HPLC)-photodiode array detection and ultra performance liquid chromatography-triple time-of-flight electrospray ionization tandem mass spectroscopy (TOF-ESI-MS/MS) analysis. Plant extracts were orally administered for 30 days at different dose levels (100 and 200 mg kg(-1) body weight (BW)) to obese C57BL/6 mice. Food intake (FI) and BW were recorded daily. Plasma biochemical parameters and lipid content were estimated at the beginning and at the end of the experiment. Liver tissues were subjected to histological examinations, lipid content, as well as oxidative stress markers, and FAME (fatty acid methyl esters) were estimated. Oral administration of extracts at 200 mg kg(-1) BW significantly reduced FI and prevented BW gain. A decrease in the weight of the liver and a decrease in the hepatic and plasma lipid content were observed. Plasma enzyme (serum glutamic-oxaloacetic transaminase, SGOT; serum glutamic pyruvic transaminase, SGPT; alkaline phosphatase, ALP) activities were not indicative of any organ damage. Chemical analysis suggested that phenolic acids (4-caffeoylquinic acid, p-coumaric acid 4-O-glucoside, 5-caffeoylshikimic acid, caffeic acid hexose, and 4-O-methyl gallic acid) and flavonoids (morusin derivatives, naringenin-7-O-glucoside, and homoisoflavanone) identified in the extracts could potentially justify the biological properties observed. The main findings of this study showed that Xylopia parviflora (A. Rich.) Benth and Aframomum citratum (Pereira ex Oliv. et Hanb.) K. Shum decreased hepatic lipid accumulation in high-fat-diet (HFD)-induced obese C57BL/6 mice and confirmed, at least in part, our previous in vitro and ex vivo studies. The molecular mechanisms underlying these effects are still unclear and will be explored in the future.
C1 [Atchan, Achille Parfait Nwakiban; Kuiate, Jules-Roger] Univ Dschang, Fac Sci, Dept Biochem, Dschang 67, Cameroon.
   [Shivashankara, Shilpa Talkad; Manjappara, Uma Venkateswaran] CSIR, Cent Food Technol Res Inst CFTRI, Dept Lipid Sci, Mysore 570020, Karnataka, India.
   [Piazza, Stefano; Dell'Agli, Mario; Magni, Paolo] Univ Milan, Dept Pharmacol & Biomol Sci, I-20133 Milan, Italy.
   [Tchamgoue, Armelle Deutou; Agbor, Gabriel Agbor] Inst Med Res & Med Plants Studies, Ctr Res Med Plants & Tradit Med, Yaounde 13033, Cameroon.
   [Beretta, Giangiacomo] Univ Milan, Dept Environm Sci & Policy, I-20133 Milan, Italy.
   [Magni, Paolo] IRCCS MultiMed, I-20099 Milan, Italy.
C3 Universite de Dschang; Council of Scientific & Industrial Research
   (CSIR) - India; CSIR - Central Food Technological Research Institute
   (CFTRI); University of Milan; University of Milan; IRCCS Multimedica
RP Manjappara, UV (corresponding author), CSIR, Cent Food Technol Res Inst CFTRI, Dept Lipid Sci, Mysore 570020, Karnataka, India.
EM umamanjappara@cftri.res.in
RI Agbor, Gabriel/AAZ-7990-2020; Magni, Paolo/AAC-2918-2019; beretta,
   giangiacomo/D-3861-2011; Mario, Dellagli/E-5253-2011; NWAKIBAN ATCHAN,
   Achille Parfait/AAX-6396-2021; Kuiate, Jules-Roger/U-9881-2019; Piazza,
   Stefano/AAR-9362-2021; Agbor, Gabriel/J-8377-2013
OI MAGNI, PAOLO/0000-0002-2254-8881; NWAKIBAN ATCHAN, Achille
   Parfait/0000-0003-1660-7125; Agbor, Gabriel/0000-0001-5860-9853;
   Manjappara, Uma/0000-0002-3209-1205
FU World Academy of Science (TWAS) in Trieste, Italy; Department of
   Biotechnology (DBT) in New Delhi, India [3240300014]; CSIR-Central Food
   Technological Research Institute, Mysore, India [MLP-263]
FX This work was supported by The World Academy of Science (TWAS) in
   Trieste, Italy, and the Department of Biotechnology (DBT) in New Delhi,
   India (Grant No. 3240300014). CSIR-Central Food Technological Research
   Institute, Mysore, India, Grant No. MLP-263.
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NR 53
TC 10
Z9 10
U1 0
U2 14
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 2470-1343
J9 ACS OMEGA
JI ACS Omega
PD MAR 30
PY 2022
VL 7
IS 14
BP 11914
EP 11928
DI 10.1021/acsomega.2c00050
PG 15
WC Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry
GA 2F3GP
UT WOS:000812801400001
PM 35449947
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Zhang, P
   Mo, DG
   Zeng, WH
   Dai, HY
AF Zhang, Peng
   Mo, Degang
   Zeng, Wenhua
   Dai, Hongyan
TI Association between triglyceride-glucose related indices and all-cause
   and cardiovascular mortality among the population with
   cardiovascular-kidney-metabolic syndrome stage 0-3: a cohort study
SO CARDIOVASCULAR DIABETOLOGY
LA English
DT Article
DE Cardiovascular-kidney-metabolic syndrome; Triglyceride-glucose index;
   Waist-to-height ratio; Waist circumference; Body mass index; All-cause
   mortality; Cardiovascular mortality
ID INSULIN-RESISTANCE; NATURAL-HISTORY; DISEASE; RISK
AB Background Cardiovascular-Kidney-Metabolic (CKM) syndrome typically commences with the interaction of insulin resistance (IR), excessive or dysfunctional obesity, and the consequent systemic inflammatory response and oxidative stress. The relationship between the triglyceride-glucose (TyG) index and TyG-related indices that may simply assess IR and obesity, as well as the mortality risk in the CKM syndrome population, remains ambiguous. Methods This study included 6,383 participants from the National Health and Nutrition Examination Survey (NHANES) 2009-2018. The TyG index, TyG-waist-to-height ratio (TyG-WHtR), TyG-waist circumference (TyG-WC), and TyG-body mass index (TyG-BMI) were developed. Cox proportional hazards models, smooth curve fitting, and two-stage Cox proportional hazards models were employed to examine the association of TyG and TyG-related indices with all-cause and cardiovascular mortality in the CKM syndrome population. Subgroup analyses and interaction tests were conducted to evaluate the risk within various demographics. Results In survey-weighted multifactorial regression analyses, a significant positive association existed between TyG, TyG-related indices, and both all-cause mortality and cardiovascular mortality, except for the TyG index, which did not demonstrate a significant link with all-cause mortality. Of these indices, the TyG-WC index exhibited the strongest correlation with all-cause mortality, with a hazard ratio (HR) of 1.50 and a 95% confidence interval (CI) of 1.18-1.92, followed by the TyG-WHtR index (HR: 1.45, 95%CI 1.13-1.85). The TyG-WHtR index demonstrated the strongest correlation with cardiovascular mortality (HR: 1.85, 95% CI 1.19-2.86), followed by the TyG-WC index(HR: 1.83, 95%CI 1.21-2.78). An L-shaped association was identified between TyG-WHtR, TyG-BMI, and all-cause mortality in CKM syndrome during the examination of nonlinear relationships (both P for log-likelihood ratio < 0.05). The TyG-WHtR, TyG-WC, and TyG-BMI indices exhibited a more pronounced correlation with all-cause mortality in those with CKM syndrome stages 1 and 3 (P value < 0.05, P for interaction < 0.05). Conclusion Our study emphasizes the association between TyG and TyG-related indices and mortality in individuals with CKM syndrome stages 0-3. Individuals with CKM syndrome stages 1 and 3 should be more vigilant to abnormal alterations in TyG-related indices.
C1 [Zhang, Peng; Mo, Degang; Dai, Hongyan] Qingdao Univ, Qingdao Municipal Hosp, Dept Cardiol, Qingdao, Peoples R China.
   [Zeng, Wenhua; Dai, Hongyan] Shandong Second Med Univ, Qingdao Municipal Hosp, Dept Cardiol, Weifang, Peoples R China.
C3 Qingdao University; Qingdao Municipal Hospital; Qingdao Municipal
   Hospital; Shandong Second Medical University
RP Dai, HY (corresponding author), Qingdao Univ, Qingdao Municipal Hosp, Dept Cardiol, Qingdao, Peoples R China.; Dai, HY (corresponding author), Shandong Second Med Univ, Qingdao Municipal Hosp, Dept Cardiol, Weifang, Peoples R China.
EM DrDaihy@163.com
RI Zhang, Peng/MBH-3828-2025
OI /0009-0003-8447-7286
FU Qingdao Outstanding Health Professional Development Fund 2025-2027
FX We express our gratitude to all participants in the NHANES study and the
   project team.
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NR 65
TC 3
Z9 3
U1 16
U2 16
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1475-2840
J9 CARDIOVASC DIABETOL
JI Cardiovasc. Diabetol.
PD FEB 28
PY 2025
VL 24
IS 1
AR 92
DI 10.1186/s12933-025-02642-7
PG 14
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism
GA Z1G8U
UT WOS:001436485700002
PM 40022225
OA gold
DA 2025-06-11
ER

PT J
AU Krishnan, RM
   Sullivan, JH
   Carlsten, C
   Wilkerson, HW
   Beyer, RP
   Bammler, T
   Farin, F
   Peretz, A
   Kaufman, JD
AF Krishnan, Ranjini M.
   Sullivan, Jeffrey H.
   Carlsten, Chris
   Wilkerson, Hui-Wen
   Beyer, Richard P.
   Bammler, Theo
   Farin, Fred
   Peretz, Alon
   Kaufman, Joel D.
TI A randomized cross-over study of inhalation of diesel exhaust,
   hematological indices, and endothelial markers in humans
SO PARTICLE AND FIBRE TOXICOLOGY
LA English
DT Article
ID PARTICULATE AIR-POLLUTION; CORONARY-HEART-DISEASE;
   MYOCARDIAL-INFARCTION; CARDIOVASCULAR-DISEASE; CULTURE SUPERNATANTS;
   SCIENTIFIC STATEMENT; METABOLIC SYNDROME; MENTAL STRESS; EXPOSURE; RISK
AB Background: Exposure to traffic-related air pollution (TRAP) is considered a trigger for acute cardiovascular events. Diesel Exhaust (DE) is a major contributor to TRAP in the world. We evaluated the effect of DE inhalation on circulating blood cell populations, hematological indices, and systemic inflammatory cytokines in humans using a specialized facility.
   Methods: In a randomized double-blind crossover study balanced to order, 17 metabolic syndrome (MetS) and 15 healthy subjects inhaled filtered air (FA) or DE exposure in two-hour sessions on different days with a minimum 2-week washout period. We collected blood pre-exposure, 7, and 22 hours after exposure initiation and measured the complete blood count and differential. We performed multiplex cytokine assay to measure the changes in the systemic inflammatory cytokines, and endothelial adhesion molecules (n=15). A paired analysis compared the effect of DE and FA exposures for the change from pre-exposure to the subsequent time points.
   Results: A significant increase in the hematocrit was noted 7 hrs after DE [1.4% (95% CI: 0.9 to 1.9%)] compared to FA exposure [0.5% (95% CI: -0.09 to 1.0%); p = 0.008. The hemoglobin levels increased non-significantly at 7 hrs post DE [0.3 gm/dL (95% CI: 0.2 to 0.5 gm/dL)] versus FA exposure [0.2 gm/dL (95% CI: 0 to 0.3 gm/dL)]; p = 0.06. Furthermore, the platelet count increased 22 hrs after DE exposure in healthy, but not in MetS subjects [DE: 16.6 (95% CI: 10.2 to 23) thousand platelets/mL versus [FA: 3.4 (95% CI: -9.5 to 16.3) thousand platelets/mL)]; p = 0.04. No DE effect was observed for WBC, neutrophils, lymphocytes or erythrocytes. Using the multiplex assay, small borderline significant increases in matrix metalloproteinase-9, interleukins (IL)-1beta, 6 and 10 occurred 7 hrs post exposure initiation, whereas E-selectin, intercellular adhesion molecule-1, and vascular cell adhesion molecule -1, and myeloperoxidase 22 hrs post exposure.
   Conclusions: Our results suggest that short-term DE exposure results in hemoconcentration and thrombocytosis, which are important determinants of acute cardiovascular events. Multiplex assay showed a non-significant increase in IL-1 beta and IL-6 immediately post exposure followed by myeloperoxidase and endothelial activation molecules. Further specific assays in a larger population will improve our understanding of the systemic inflammatory mechanisms following acute exposure to TRAP.
   Clinical trials registration number: Study was conducted between 2004 to 2006, prior to expectation for registration.
C1 [Krishnan, Ranjini M.; Kaufman, Joel D.] Univ Washington, Dept Med, Seattle, WA 98195 USA.
   [Krishnan, Ranjini M.; Sullivan, Jeffrey H.; Carlsten, Chris; Wilkerson, Hui-Wen; Beyer, Richard P.; Bammler, Theo; Farin, Fred; Peretz, Alon; Kaufman, Joel D.] 3 Epidemiol Univ Washington, Seattle, WA USA.
   [Kaufman, Joel D.] Univ Washington, Sch Publ Hlth, Seattle, WA 98195 USA.
C3 University of Washington; University of Washington Seattle; University
   of Washington; University of Washington Seattle
RP Krishnan, RM (corresponding author), Univ Washington, Dept Med, Seattle, WA 98195 USA.
EM ranjik@u.washington.edu
RI Kaufman, Joel/B-5761-2008
OI Kaufman, Joel/0000-0003-4174-9037
FU EPA [RD-830954]; NIEHS [K24ES013195, K23ES1113901, P30ES07033, P50
   ES015915]
FX We would like to express our sincere appreciation to Mary Aulet, who
   coordinated the study and helped with the recruitment of the subjects
   and Jim Stewart for operating the controlled exposure facility. This
   study was funded by EPA grant RD-830954, NIEHS grants K24ES013195,
   K23ES1113901, P30ES07033, and P50 ES015915.
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NR 51
TC 59
Z9 71
U1 1
U2 18
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1743-8977
J9 PART FIBRE TOXICOL
JI Part. Fibre Toxicol.
PD MAR 26
PY 2013
VL 10
AR 7
DI 10.1186/1743-8977-10-7
PG 10
WC Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Toxicology
GA 206MX
UT WOS:000323527000001
PM 23531317
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Farinango, CD
   Benavides, JS
   Cerón, JD
   López, DM
   Alvarez, RE
AF Farinango, Charic D.
   Benavides, Juan S.
   Ceron, Jesus D.
   Lopez, Diego M.
   Alvarez, Rosa E.
TI Human-centered design of a personal health record system for metabolic
   syndrome management based on the ISO 9241-210:2010 standard
SO JOURNAL OF MULTIDISCIPLINARY HEALTHCARE
LA English
DT Article
DE human-centered design; ISO 9241-210; software development process;
   personal health record system; usability evaluation
ID MEDICATION MANAGEMENT; INTERVENTIONS; INFORMATION; PLATFORM; WOMEN
AB Background: Previous studies have demonstrated the effectiveness of information and communication technologies to support healthy lifestyle interventions. In particular, personal health record systems (PHR-Ss) empower self-care, essential to support lifestyle changes. Approaches such as the user-centered design (UCD), which is already a standard within the software industry (ISO 9241-210: 2010), provide specifications and guidelines to guarantee user acceptance and quality of eHealth systems. However, no single PHR-S for metabolic syndrome (MS) developed following the recommendations of the ISO 9241-210: 2010 specification has been found in the literature.
   Objective: The aim of this study was to describe the development of a PHR-S for the management of MS according to the principles and recommendations of the ISO 9241-210 standard.
   Methods: The proposed PHR-S was developed using a formal software development process which, in addition to the traditional activities of any software process, included the principles and recommendations of the ISO 9241-210 standard. To gather user information, a survey sample of 1,187 individuals, eight interviews, and a focus group with seven people were performed. Throughout five iterations, three prototypes were built. Potential users of each system evaluated each prototype. The quality attributes of efficiency, effectiveness, and user satisfaction were assessed using metrics defined in the ISO/IEC 25022 standard.
   Results: The following results were obtained: 1) a technology profile from 1,187 -individuals at risk for MS from the city of Popayan, Colombia, identifying that 75.2% of the people use the Internet and 51% had a smartphone; 2) a PHR-S to manage MS developed (the PHR-S has the -following five main functionalities: record the five MS risk factors, share these measures with health care professionals, and three educational modules on nutrition, stress management, and a physical activity); and 3) usability tests on each prototype obtaining the following results: 100% effectiveness, 100% efficiency, and 84.2 points in the system usability scale.
   Conclusion: The software development methodology used was based on the ISO 9241-210 standard, which allowed the development team to maintain a focus on user's needs and requirements throughout the project, which resulted in an increased satisfaction and acceptance of the system. Additionally, the establishment of a multidisciplinary team allowed the application of considerations not only from the disciplines of software engineering and health sciences but also from other disciplines such as graphical design and media communication. Finally, usability testing allowed the observation of flaws in the designs, which helped to improve the solution.
C1 [Farinango, Charic D.; Benavides, Juan S.; Ceron, Jesus D.; Lopez, Diego M.] Univ Cauca, Fac Elect & Telecommun Engn, Telemat Engn Res Grp, Popayan, Colombia.
   [Alvarez, Rosa E.] Univ Cauca, Fac Hlth Sci, Human Genet Res Grp, Popayan, Colombia.
C3 Universidad del Cauca; Universidad del Cauca
RP López, DM (corresponding author), Univ Cauca, Calle 5 4-70, Popayan 19002, Colombia.
EM dmlopez@unicauca.edu.co
RI Lopez, Diego/AAF-8361-2019; Ceron Bravo, Jesus David/Q-6267-2017
OI Lopez, Diego/0000-0001-9425-4375; Ceron Bravo, Jesus
   David/0000-0001-7210-6312
FU Colombian Administrative Department of Science and Technology in
   Colombia (Colciencias) [110356935192/CTO: 743-2013, 569-2012]
FX The work has been funded by the Colombian Administrative Department of
   Science and Technology in Colombia (Colciencias) - Call 569-2012 under
   the project SIMETIC: Una estrategia para la caracterizacion y
   autocuidado de pacientes con Sindrome Metabolico soportada en
   Tecnologias de la Informacion y la Comunicacion (TIC), under contract
   number 110356935192/CTO: 743-2013.
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NR 39
TC 14
Z9 16
U1 1
U2 21
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-2390
J9 J MULTIDISCIP HEALTH
JI J. Multidiscip. Healthc.
PY 2018
VL 11
BP 21
EP 37
DI 10.2147/JMDH.S150976
PG 17
WC Health Care Sciences & Services
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Health Care Sciences & Services
GA FS8NN
UT WOS:000422669200001
PM 29386903
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Huang, W
   Huang, GP
   Zhang, LX
   da Yu, E
   Yang, WK
   Ye, M
   Zou, SQ
   Ni, L
   He, HQ
AF Huang, Wei
   Huang, Guan-peng
   Zhang, Lan-xiong
   da Yu, En
   Yang, Wang-ke
   Ye, Min
   Zou, Shuang-quan
   Ni, Lin
   He, Hua-Qin
TI Lignan-rich extract from Cinnamomum camphora leaf attenuates
   metabolic syndrome by modulating glycolipid metabolism and gut
   microbiota in T2DM mice
SO PHYTOMEDICINE
LA English
DT Article
DE Cinnamomum camphora; Lignan; Diabetes; Glycometabolism; Gut microbiota
ID DIABETES-MELLITUS; INSULIN-RESISTANCE; ALPHA-GLUCOSIDASE;
   LIPID-METABOLISM; SESAMIN; AMYLASE; MODEL
AB Background: Type 2 diabetes mellitus (T2DM) is a serious metabolic syndrome with high mortality and disability rates globally, which usually caused by unhealthy dietary patterns. Cinnamomum camphora leaf is a traditional Chinese medicinal herb used for attenuating hyperglycemia and digestive disorder, and high level of lignans has been found in C. camphora leaf. Purpose: This study aimed to examine the chemical composition of lignans extracted from C. camphora leaf (LCCL), and illustrate its therapeutic effect and mechanism on T2DM and its concomitant glycolipid metabolic disorder. Methods: The components of LCCL were separated and purified by silica gel and macroporous adsorption resin, and were distinguished through LC/MS and NMR. The antioxidant activity of LCCL was determined by free radical scavenging assay in vitro; the hypoglycemic and hypolipidemic abilities were evaluated by alpha-glucosidase, alpha-amylase and pancreatic lipase inhibition trials, respectively. T2DM model mice were established by high-sugar and high-fat (HSHF) feed together with streptozotocin (STZ) infection, and then grouped to assess the effect of LCCL treatment. Hematoxylin-eosin (H&E), Periodic Acid-Schiff (PAS) and oil red O staining were employed to analyze the histopathology. qRT-PCR assay, 16S rRNA analysis, and western blot were conducted to illuminate the anti-diabetic mechanism of LCCL. Results: 6 sesamin lignans were identifed from LCCL. The in vitro assays showed strong inhibitive abilities of LCCL with low IC50 on DPPH (33.68 +/- 0.54 mu g/ml),O-2(-) (39.25 +/- 0.61 mu g/ml), OH center dot (45.72 +/- 0.72 mu g/ml), alpha-glucosidase (0.82 +/- 0.14 mg/ml), alpha-amylase (0.86 +/- 0.11 mg/ml) and pancreatic lipase (0.91 +/- 0.12 mg/ml). LCCL treatment (100, 200 and 400 g kg(-1mg kg-1)) gradually decreased the fasting blood glucose (FBG) and fasting insulin (FINS), improved the glucose and insulin tolerance, down-regulated the homeostasis model assessment insulin resistance (HOMA-IR) indexes, alleviated the hepatic inflammatory response and oxidative stress, promoted the glycogen storage and depleted the fat accumulation in the liver. Besides, LCCL administration alleviated the glycolipid metabolism disorder in T2DM mice with a gut microbiota dependent manner, that significantly increased biodiversity, altered the composition of gut microbiota and increased the proportion of Lactobacillus. Conclusion: The lignan-rich extract of C. camphor leaf (LCCL), containing at least 6 lignans compounds, displayed promising antioxidant, hypoglycemic and hypolipidemic activities. The treatment of LCCL alleviated the glycolipid metabolism disorder in T2DM mice with a gut microbiota dependent manner. These finding suggested that LCCL should be further investigated to develop its complementary therapeutic effect on T2DM.
C1 [Huang, Wei; Huang, Guan-peng; da Yu, En; Yang, Wang-ke; He, Hua-Qin] Fujian Agr & Forestry Univ, Coll Life Sci, Fuzhou 350002, Peoples R China.
   [Huang, Wei; Zhang, Lan-xiong; Zou, Shuang-quan; Ni, Lin] Fujian Agr & Forestry Univ, Engn Res Inst Conservat Utilizat Nat Bioresources, Fuzhou, Peoples R China.
   [Huang, Guan-peng] Fujian Agr & Forestry Univ, Coll JunCao Sci & Ecol, Coll Carbon Neutral, Fuzhou, Peoples R China.
   [Zhang, Lan-xiong; Ni, Lin] Fujian Agr & Forestry Univ, Coll Plant Protect, Fuzhou, Peoples R China.
   [Ye, Min] Fujian Med Univ, Sch Pharm, Fujian Key Lab Nat Med Pharmacol, Fuzhou 350004, Peoples R China.
C3 Fujian Agriculture & Forestry University; Fujian Agriculture & Forestry
   University; Fujian Agriculture & Forestry University; Fujian Agriculture
   & Forestry University; Fujian Medical University
RP Huang, W; Ni, L; He, HQ (corresponding author), Fujian Agr & Forestry Univ, Coll Life Sci, 15 Shangxiadian Rd, Fuzhou 350002, Fujian, Peoples R China.
EM huangwei@fafu.edu.cn; nilin_fjau@126.com; hehq3@fafu.edu.cn
FU China National Forestry and Grassland Administration Central Finance
   Forestry Science and Technology Promotion Project [Min 2022 TG-16];
   Guiding project of Fujian Provincial Department of Science and
   Technology [2023N0003]; Fujian Forestry Science Research Project
   [2023FKJ28]; Fujian Quanzhou Science and Technology Bureau Project
   [2022C004QR]
FX This work was supported by China National Forestry and Grassland
   Administration Central Finance Forestry Science and Technology Promotion
   Project (Min 2022 TG-16) , Guiding project of Fujian Provincial
   Department of Science and Technology (2023N0003) , Fujian Forestry
   Science Research Project (2023FKJ28) , and Fujian Quanzhou Science and
   Technology Bureau Project (2022C004QR)
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NR 64
TC 5
Z9 5
U1 19
U2 36
PU ELSEVIER GMBH
PI MUNICH
PA HACKERBRUCKE 6, 80335 MUNICH, GERMANY
SN 0944-7113
EI 1618-095X
J9 PHYTOMEDICINE
JI Phytomedicine
PD DEC
PY 2024
VL 135
AR 156118
DI 10.1016/j.phymed.2024.156118
EA OCT 2024
PG 14
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA L0E4P
UT WOS:001347539900001
PM 39489989
DA 2025-06-11
ER

PT J
AU Ezrokhi, M
   Luo, SQ
   Trubitsyna, Y
   Cincotta, AH
AF Ezrokhi, Michael
   Luo, Shuqin
   Trubitsyna, Yelena
   Cincotta, Anthony H.
TI Neuroendocrine and metabolic components of dopamine agonist amelioration
   of metabolic syndrome in SHR rats
SO DIABETOLOGY & METABOLIC SYNDROME
LA English
DT Article
DE Neuroendocrine; Bromocriptine; Diabetes; Insulin resistance; Resetting
ID HEPATIC INSULIN-RESISTANCE; SPONTANEOUSLY HYPERTENSIVE-RATS;
   ACTIVATED-RECEPTOR-GAMMA; FATTY-ACID OXIDATION; ENDOPLASMIC-RETICULUM
   STRESS; HAMSTER MESOCRICETUS-AURATUS; WISTAR-KYOTO RATS; NF-KAPPA-B;
   BLOOD-PRESSURE; GLUCOSE-INTOLERANCE
AB Background: The hypertensive, pro-inflammatory, obese state is strongly coupled to peripheral and hepatic insulin resistance (in composite termed metabolic syndrome [ MS]). Hepatic pro-inflammatory pathways have been demonstrated to initiate or exacerbate hepatic insulin resistance and contribute to fatty liver, a correlate of MS. Previous studies in seasonally obese animals have implicated an important role for circadian phase-dependent increases in hypothalamic dopaminergic tone in the maintenance of the lean, insulin sensitive condition. However, mechanisms driving this dopaminergic effect have not been fully delineated and the impact of such dopaminergic function upon the above mentioned parameters of MS, particularly upon key intra-hepatic regulators of liver inflammation and lipid and glucose metabolism have never been investigated.
   Objective: This study therefore investigated the effects of timed daily administration of bromocriptine, a potent dopamine D2 receptor agonist, on a) ventromedial hypothalamic catecholamine activity, b) MS and c) hepatic protein levels of key regulators of liver inflammation and glucose and lipid metabolism in a non-seasonal model of MS - the hypertensive, obese SHR rat.
   Methods: Sixteen week old SHR rats maintained on 14 hour daily photoperiods were treated daily for 16 days with bromocriptine (10 mg/kg, i.p.) or vehicle at 1 hour before light offset and, subsequent to blood pressure recordings on day 14, were then utilized for in vivo microdialysis of ventromedial hypothalamic catecholamine activity or sacrificed for the analyses of MS factors and regulators of hepatic metabolism. Normal Wistar rats served as wild-type controls for hypothalamic activity, body fat levels, and insulin sensitivity.
   Results: Bromocriptine treatment significantly reduced ventromedial hypothalamic norepinephrine and serotonin levels to the normal range and systolic and diastolic blood pressures, retroperitoneal body fat level, plasma insulin and glucose levels and HOMA-IR relative to vehicle treated SHR controls. Such treatment also reduced plasma levels of C-reactive protein, leptin, and norepinephrine and increased that of plasma adiponectin significantly relative to SHR controls. Finally, bromocriptine treatment significantly reduced hepatic levels of several pro-inflammatory pathway proteins and of the master transcriptional activators of lipogenesis, gluconeogenesis, and free fatty acid oxidation versus control SHR rats.
   Conclusion: These findings indicate that in SHR rats, timed daily dopamine agonist treatment improves hypothalamic and neuroendocrine pathologies associated with MS and such neuroendocrine events are coupled to a transformation of liver metabolism potentiating a reduction of elevated lipogenic and gluconeogenic capacity. This liver effect may be driven in part by concurrent reductions in hyperinsulinemia and sympathetic tone as well as by reductions in intra-hepatic inflammation.
C1 [Ezrokhi, Michael; Luo, Shuqin; Trubitsyna, Yelena; Cincotta, Anthony H.] VeroScience LLC, Tiverton, RI 02878 USA.
RP Cincotta, AH (corresponding author), VeroScience LLC, Tiverton, RI 02878 USA.
EM Anthony_Cincotta@veroscience.com
RI Ezrokhi, Michael/IRZ-4665-2023
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NR 125
TC 33
Z9 33
U1 1
U2 9
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1758-5996
J9 DIABETOL METAB SYNDR
JI Diabetol. Metab. Syndr.
PD SEP 25
PY 2014
VL 6
AR 104
DI 10.1186/1758-5996-6-104
PG 18
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA AR7QW
UT WOS:000343775300001
PM 25937836
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Guivala, SJ
   Bode, KA
   Okun, JG
   Kartal, E
   Schwedhelm, E
   Pohl, LV
   Werner, S
   Erbs, S
   Thiele, H
   Büttner, P
AF Guivala, Salmina J.
   Bode, Konrad A.
   Okun, Juergen G.
   Kartal, Ece
   Schwedhelm, Edzard
   Pohl, Luca V.
   Werner, Sarah
   Erbs, Sandra
   Thiele, Holger
   Buettner, Petra
TI Interactions between the gut microbiome, associated metabolites and the
   manifestation and progression of heart failure with preserved ejection
   fraction in ZSF1 rats
SO CARDIOVASCULAR DIABETOLOGY
LA English
DT Article
DE HFpEF; TMAO; Intestinal microbiome; Inflammation; Intestinal barrier;
   FMO3; ZSF1-rats
ID TRIMETHYLAMINE-N-OXIDE; BARRIER DYSFUNCTION; MODULATE
AB BackgroundHeart failure with preserved ejection fraction (HFpEF) is associated with systemic inflammation, obesity, metabolic syndrome, and gut microbiome changes. Increased trimethylamine-N-oxide (TMAO) levels are predictive for mortality in HFpEF. The TMAO precursor trimethylamine (TMA) is synthesized by the intestinal microbiome, crosses the intestinal barrier and is metabolized to TMAO by hepatic flavin-containing monooxygenases (FMO). The intricate interactions of microbiome alterations and TMAO in relation to HFpEF manifestation and progression are analyzed here.MethodsHealthy lean (L-ZSF1, n = 12) and obese ZSF1 rats with HFpEF (O-ZSF1, n = 12) were studied. HFpEF was confirmed by transthoracic echocardiography, invasive hemodynamic measurements, and detection of N-terminal pro-brain natriuretic peptide (NT-proBNP). TMAO, carnitine, symmetric dimethylarginine (SDMA), and amino acids were measured using mass-spectrometry. The intestinal epithelial barrier was analyzed by immunohistochemistry, in-vitro impedance measurements and determination of plasma lipopolysaccharide via ELISA. Hepatic FMO3 quantity was determined by Western blot. The fecal microbiome at the age of 8, 13 and 20 weeks was assessed using 16s rRNA amplicon sequencing.ResultsIncreased levels of TMAO (+ 54%), carnitine (+ 46%) and the cardiac stress marker NT-proBNP (+ 25%) as well as a pronounced amino acid imbalance were observed in obese rats with HFpEF. SDMA levels in O-ZSF1 were comparable to L-ZSF1, indicating stable kidney function. Anatomy and zonula occludens protein density in the intestinal epithelium remained unchanged, but both impedance measurements and increased levels of LPS indicated an impaired epithelial barrier function. FMO3 was decreased (- 20%) in the enlarged, but histologically normal livers of O-ZSF1. Alpha diversity, as indicated by the Shannon diversity index, was comparable at 8 weeks of age, but decreased by 13 weeks of age, when HFpEF manifests in O-ZSF1. Bray-Curtis dissimilarity (Beta-Diversity) was shown to be effective in differentiating L-ZSF1 from O-ZSF1 at 20 weeks of age. Members of the microbial families Lactobacillaceae, Ruminococcaceae, Erysipelotrichaceae and Lachnospiraceae were significantly differentially abundant in O-ZSF1 and L-ZSF1 rats.ConclusionsIn the ZSF1 HFpEF rat model, increased dietary intake is associated with alterations in gut microbiome composition and bacterial metabolites, an impaired intestinal barrier, and changes in pro-inflammatory and health-predictive metabolic profiles. HFpEF as well as its most common comorbidities obesity and metabolic syndrome and the alterations described here evolve in parallel and are likely to be interrelated and mutually reinforcing. Dietary adaption may have a positive impact on all entities.
C1 [Guivala, Salmina J.] Univ Hosp Heidelberg, Dept Cardiol Angiol & Pulmonol, Neuenheimer Feld 410, D-69120 Heidelberg, Germany.
   [Bode, Konrad A.] Lab Dr Limbach & Colleagues, Dept Mol Diag, Lab Dr,Breitspiel 15, D-69126 Heidelberg, Germany.
   [Okun, Juergen G.] Univ Childrens Hosp Heidelberg, Dept Gen Pediat, Div Neuropediat & Metab Med, Neuenheimer Feld 400, D-69120 Heidelberg, Germany.
   [Kartal, Ece] Heidelberg Univ, Fac Med, Neuenheimer Feld 267, D-69120 Heidelberg, Germany.
   [Kartal, Ece] Heidelberg Univ, Heidelberg Univ Hosp, Inst Computat Biomed, Bioquant, Neuenheimer Feld 267, D-69120 Heidelberg, Germany.
   [Schwedhelm, Edzard] Univ Med Ctr Hamburg Eppendorf, Inst Clin Pharmacol & Toxicol, Martinistr 52, D-20246 Hamburg, Germany.
   [Pohl, Luca V.; Werner, Sarah; Erbs, Sandra; Thiele, Holger; Buettner, Petra] Univ Leipzig, Heart Ctr Leipzig, Strumpellstr 89, D-04289 Leipzig, Germany.
C3 Ruprecht Karls University Heidelberg; Ruprecht Karls University
   Heidelberg; Ruprecht Karls University Heidelberg; Ruprecht Karls
   University Heidelberg; University of Hamburg; University Medical Center
   Hamburg-Eppendorf; Leipzig University; Heart Center Leipzig GMBH
RP Guivala, SJ (corresponding author), Univ Hosp Heidelberg, Dept Cardiol Angiol & Pulmonol, Neuenheimer Feld 410, D-69120 Heidelberg, Germany.
EM salminajose.guivala@med.uni-heidelberg.de
RI Thiele, Holger/ABE-6792-2020; Büttner, Petra/JSK-8072-2023
FU Universittsklinikum Heidelberg (8914)
FX Not applicable.
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NR 75
TC 7
Z9 7
U1 2
U2 5
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1475-2840
J9 CARDIOVASC DIABETOL
JI Cardiovasc. Diabetol.
PD AUG 14
PY 2024
VL 23
IS 1
AR 299
DI 10.1186/s12933-024-02398-6
PG 16
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism
GA C6U6K
UT WOS:001290706900002
PM 39143579
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Shi, CX
   Wen, ZZ
   Yang, YH
   Shi, LS
   Liu, D
AF Shi, Chongxu
   Wen, Zhaozhi
   Yang, Yihang
   Shi, Linsheng
   Liu, Dong
TI NAD plus metabolism and therapeutic strategies in cardiovascular
   diseases
SO ATHEROSCLEROSIS PLUS
LA English
DT Article
DE Nicotinamide adenine dinucleotide; Atherosclerosis; Cardiovascular
   diseases; Vascular disorder
ID MYOCARDIAL ISCHEMIA/REPERFUSION INJURY; E-DEFICIENT MICE; NICOTINAMIDE
   MONONUCLEOTIDE; ENDOTHELIAL DYSFUNCTION; MITOCHONDRIAL-FUNCTION;
   RESVERATROL SUPPLEMENTATION; IMPROVES MITOCHONDRIAL; ACTIVATING SIRT1;
   DNA-DAMAGE; CD38
AB Nicotinamide adenine dinucleotide (NAD+) is a central and pleiotropic metabolite involved in cellular energy metabolism, cell signaling, DNA repair, and protein modifications. Cardiovascular diseases (CVDs) are the leading cause of death worldwide. Metabolic stress and aging directly affect the cardiovascular system. Compelling data suggest that NAD + levels decrease with age, obesity, and hypertension, which are all notable risk factors for CVD. In addition, the therapeutic elevation of NAD + levels reduces chronic low-grade inflammation, reactivates autophagy and mitochondrial biogenesis, and enhances oxidative metabolism in vascular cells of humans and rodents with vascular disorders. In preclinical models, NAD + boosting can also expand the health span, prevent metabolic syndrome, and decrease blood pressure. Moreover, NAD + storage by genetic, pharmacological, or natural dietary NAD + -increasing strategies has recently been shown to be effective in improving the pathophysiology of cardiac and vascular health in different animal models, and human health. Here, we review and discuss NAD + -related mechanisms pivotal for vascular health and summarize recent experimental evidence in NAD + research directly related to vascular disease, including atherosclerosis, and coronary artery disease. Finally, we comparatively assess distinct NAD + precursors for their clinical efficacy and the efficiency of NAD + elevation in the treatment of major CVD. These findings may provide ideas for new therapeutic strategies to prevent and treat CVD in the clinic.
C1 [Shi, Chongxu; Wen, Zhaozhi; Yang, Yihang; Liu, Dong] Nantong Univ, Sch Life Sci, Nantong Lab Dev & Dis, Nantong, Peoples R China.
   [Shi, Linsheng; Liu, Dong] Nantong Univ, Affiliated Hosp 2, Dept Cardiol, Nantong, Peoples R China.
   [Liu, Dong] Nantong Univ, Coinnovat Ctr Neuroregenerat, Key Lab Neuroregenerat Jiangsu & Minist Educ, Nantong 226001, Peoples R China.
C3 Nantong University; Nantong University; Nantong University
RP Shi, CX; Liu, D (corresponding author), Nantong Univ, Sch Life Sci, Nantong Lab Dev & Dis, Nantong, Peoples R China.; Shi, LS; Liu, D (corresponding author), Nantong Univ, Affiliated Hosp 2, Dept Cardiol, Nantong, Peoples R China.
EM Chongxu.shi@gmail.com; shilinsheng@ntu.edu.cn; liudongtom@gmail.com
RI Liu, Dong/IZQ-5612-2023; Shi, Chongxu/ABG-4523-2020
OI Shi, Chong-xu/0009-0006-2012-2322
FU National Natural Science Foundation of China [82200462, 2018YFA0801004];
   Jiangsu Commission of Health [LKM2022060]; Nantong Science and
   Technology Bureau [JC12022017]
FX This work was supported by the National Natural Science Foundation of
   China (82200462 for CS, 2018YFA0801004 for DL) , a grant from the
   Jiangsu Commission of Health (Grant No. LKM2022060) , and a grant from
   the Nantong Science and Technology Bureau (Grant No. JC12022017 for CS)
   .
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NR 157
TC 5
Z9 5
U1 8
U2 17
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2667-0909
EI 2667-0895
J9 ATHEROSCLEROSIS PLUS
JI Atheroscler. Plus
PD SEP
PY 2024
VL 57
BP 1
EP 12
DI 10.1016/j.athplu.2024.06.001
EA JUN 2024
PG 12
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA WE8D4
UT WOS:001253275500001
PM 38974325
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Moeini, R
   Shirafkan, H
   Gorji, N
AF Moeini, Reihaneh
   Shirafkan, Hoda
   Gorji, Narjes
TI Pomegranate effects on the health aspects of women during peri- and
   postmenopause: A systematic review and meta-analysis
SO PHYTOTHERAPY RESEARCH
LA English
DT Review
DE estradiol; hot flashes; menopause; metabolic syndrome; oxidative stress;
   pomegranate
ID MENOPAUSAL SYMPTOMS; HOT FLASHES; ISOFLAVONE SUPPLEMENTS; LIPID PROFILE;
   SEED OIL; CONSUMPTION; JUICE; PHYTOESTROGENS; EXTRACT; GLUCOSE
AB Pomegranate is widely used to preserve human health and help prevent many kinds of diseases. This study aims to review and assess the effects of pomegranate on women's health during and after menopause. PubMed, Web of science, Cochrane, Scopus, and Google Scholar were searched up to the end of 2022 with no language or study type restriction. All types of clinical research studies (randomized clinical trial [RCT], pre-post, case report, and case series) were included. The Cochrane RoB 2.0 tool was used for quality assessment of RCTs. A summary of intervention's effects for each study was provided by calculating standardized mean differences and accompanying 95% confidence interval using random effect model. Weighted mean differences and heterogeneity between studies were assessed using Hedges's method and Cochran's Q test, respectively. Pomegranate can significantly improve hot flashes severity and menopause symptoms and decrease FSH. It significantly improves high-density lipoprotein but not low-density lipoprotein, body mass index, and weight. Most of our results are inconclusive, and the small sample sizes and the lack of blinding and randomization have led to an increased risk of bias. Pomegranate can decrease menopause symptoms, but more well-designed studies, with bigger sample sizes are needed to establish its other clinical benefits for menopausal women.
C1 [Moeini, Reihaneh; Gorji, Narjes] Babol Univ Med Sci, Hlth Res Inst, Tradit Med & Hist Med Sci Res Ctr, Babol, Iran.
   [Shirafkan, Hoda] Babol Univ Med Sci, Hlth Res Inst, Social Determinants Hlth Res Ctr, Babol, Iran.
   [Gorji, Narjes] Babol Univ Med Sci, Tradit Med & Hist Med Sci Res Ctr, Sch Iranian Tradit Med, Dept Tradit Med, Babol, Iran.
C3 Babol University of Medical Sciences; Babol University of Medical
   Sciences; Babol University of Medical Sciences
RP Gorji, N (corresponding author), Babol Univ Med Sci, Tradit Med & Hist Med Sci Res Ctr, Sch Iranian Tradit Med, Dept Tradit Med, Babol, Iran.
EM n.gorji@mubabol.ac.ir
RI Gorji, Narjes/N-7751-2017; Shirafkan, Hoda/AAE-8403-2020; Moeini,
   Reihaneh/GLN-3842-2022
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NR 74
TC 3
Z9 3
U1 0
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0951-418X
EI 1099-1573
J9 PHYTOTHER RES
JI Phytother. Res.
PD JAN
PY 2024
VL 38
IS 1
BP 368
EP 383
DI 10.1002/ptr.8036
EA NOV 2023
PG 16
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA GP7Q2
UT WOS:001096392400001
PM 37929766
DA 2025-06-11
ER

PT J
AU Kang, Q
   Sun, JY
   Wang, BW
   Sun, BG
AF Kang, Qiao
   Sun, Jinyuan
   Wang, Bowen
   Sun, Baoguo
TI Wine, beer and Chinese Baijiu in relation to cardiovascular health: the
   impact of moderate drinking
SO FOOD SCIENCE AND HUMAN WELLNESS
LA English
DT Article
DE Alcohol; Cardiovascular disease; Distilled spirits; Wine; Beer; Chinese
   Baijiu
ID CORONARY-HEART-DISEASE; HIGH-DENSITY-LIPOPROTEIN; INDUCED OXIDATIVE
   STRESS; ALCOHOL-CONSUMPTION; METABOLIC SYNDROME; ENDOTHELIAL FUNCTION;
   OLDER-ADULTS; ALL-CAUSE; RISK; RESVERATROL
AB Excessive alcohol consumption (>= 15 drinks per week) causes chronic diseases and multiple other health conditions. Nevertheless, alcohol beverages have been used as a vital medicine ingredient in various cultures since ancient times. A wealth of epidemiological and experimental research has shown that light-moderate alcohol consumption, regardless of beverage type, is associated with reducing cardiovascular incidence and mortality rate. Due to the disparities in raw materials, fermentation techniques, production environment, etc., alcoholic beverages tend to possess different non-ethanol component profiles, thus resulting in varying degrees of health effects. Furthermore, bioactive compounds in alcohol are continuously discovered as well as the mechanisms underlying their cardioprotective contributions at a molecular level. This article elucidates the epidemiology of moderate alcohol consumption and various cardiovascular conditions, along with the limitations and controversies of current studies. In addition, protective effects and putative mechanisms of both ethanol and non-ethanol components of wine, beer, and Chinese Baijiu, the three most representative alcoholic beverages worldwide, are to be evaluated within the context of a rational drinking pattern.(c) 2023 Beijing Academy of Food Sciences. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co., Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
C1 [Kang, Qiao; Sun, Jinyuan; Wang, Bowen; Sun, Baoguo] Beijing Technol & Business Univ, Beijing Lab Food Qual & Safety, Beijing 100048, Peoples R China.
   [Kang, Qiao; Sun, Jinyuan; Wang, Bowen; Sun, Baoguo] Beijing Technol & Business Univ, Key Lab Brewing Mol Engn China Light Ind, Beijing 100048, Peoples R China.
   [Sun, Jinyuan; Sun, Baoguo] Beijing Technol & Business Univ, Beijing 100048, Peoples R China.
C3 Beijing Technology & Business University; Beijing Technology & Business
   University; Beijing Technology & Business University
RP Sun, JY; Sun, BG (corresponding author), Beijing Technol & Business Univ, Beijing 100048, Peoples R China.
EM sunjinyuan@btbu.edu.cn; sunbg@btbu.edu.cn
RI KANG, QIAO/AAJ-4151-2021; Wang, Bowen/JAO-0168-2023; Sun,
   Jinyuan/HGA-9546-2022
OI Wang, Bowen/0000-0003-3372-2678; Sun, Jinyuan/0000-0001-6717-9787
FU National Natural Science Foundation of P.R. China [31972193]; Science
   and Technology Program of Tibet Autonomous Region, China
   [XZ202001ZY0017N]
FX Acknowledgments This work was supported by the National Natural Science
   Foundation of P.R. China (No.31972193) and the Science and Technology
   Program of Tibet Autonomous Region, China (XZ202001ZY0017N) .
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NR 152
TC 26
Z9 30
U1 20
U2 187
PU TSINGHUA UNIV PRESS
PI BEIJING
PA B605D, XUE YAN BUILDING, BEIJING, 100084, PEOPLES R CHINA
EI 2213-4530
J9 FOOD SCI HUM WELL
JI Food Sci. Human Wellness
PD JAN
PY 2023
VL 12
IS 1
BP 1
EP 13
DI 10.1016/j.fshw.2022.07.013
PG 13
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA 3Z5EK
UT WOS:000844439800001
OA gold
DA 2025-06-11
ER

PT J
AU Nasiri-Ansari, N
   Androutsakos, T
   Flessa, CM
   Kyrou, I
   Siasos, G
   Randeva, HS
   Kassi, E
   Papavassiliou, AG
AF Nasiri-Ansari, Narjes
   Androutsakos, Theodoros
   Flessa, Christina-Maria
   Kyrou, Ioannis
   Siasos, Gerasimos
   Randeva, Harpal S.
   Kassi, Eva
   Papavassiliou, Athanasios G.
TI Endothelial Cell Dysfunction and Nonalcoholic Fatty Liver Disease
   (NAFLD): A Concise Review
SO CELLS
LA English
DT Review
DE vascular endothelial cells; sinusoidal endothelial cells; endothelial
   dysfunction; NAFLD; LSECs; CVD; inflammation
ID NITRIC-OXIDE SYNTHASE; ENDOPLASMIC-RETICULUM STRESS;
   ISCHEMIA-REPERFUSION INJURY; CORONARY-HEART-DISEASE; CIRRHOTIC RAT
   LIVERS; KAPPA-B ACTIVATION; INSULIN-RESISTANCE; SELENOPROTEIN P;
   ASYMMETRIC DIMETHYLARGININE; SUBCLINICAL ATHEROSCLEROSIS
AB Nonalcoholic fatty liver disease (NAFLD) is one of the most common liver diseases worldwide. It is strongly associated with obesity, type 2 diabetes (T2DM), and other metabolic syndrome features. Reflecting the underlying pathogenesis and the cardiometabolic disorders associated with NAFLD, the term metabolic (dysfunction)-associated fatty liver disease (MAFLD) has recently been proposed. Indeed, over the past few years, growing evidence supports a strong correlation between NAFLD and increased cardiovascular disease (CVD) risk, independent of the presence of diabetes, hypertension, and obesity. This implies that NAFLD may also be directly involved in the pathogenesis of CVD. Notably, liver sinusoidal endothelial cell (LSEC) dysfunction appears to be implicated in the progression of NAFLD via numerous mechanisms, including the regulation of the inflammatory process, hepatic stellate activation, augmented vascular resistance, and the distortion of microcirculation, resulting in the progression of NAFLD. Vice versa, the liver secretes inflammatory molecules that are considered pro-atherogenic and may contribute to vascular endothelial dysfunction, resulting in atherosclerosis and CVD. In this review, we provide current evidence supporting the role of endothelial cell dysfunction in the pathogenesis of NAFLD and NAFLD-associated atherosclerosis. Endothelial cells could thus represent a "golden target" for the development of new treatment strategies for NAFLD and its comorbid CVD.
C1 [Nasiri-Ansari, Narjes; Flessa, Christina-Maria; Kassi, Eva; Papavassiliou, Athanasios G.] Natl & Kapodistrian Univ Athens, Med Sch, Dept Biol Chem, Athens 11527, Greece.
   [Androutsakos, Theodoros] Natl & Kapodistrian Univ Athens, Med Sch, Dept Pathophysiol, Athens 11527, Greece.
   [Flessa, Christina-Maria; Kyrou, Ioannis; Randeva, Harpal S.] Univ Hosp Coventry & Warwickshire NHS Trust, Warwickshire Inst Study Diabet Endocrinol & Metab, Coventry CV2 2DX, W Midlands, England.
   [Kyrou, Ioannis; Randeva, Harpal S.] Univ Warwick, Warwick Med Sch, Coventry CV4 7AL, W Midlands, England.
   [Kyrou, Ioannis] Agr Univ Athens, Sch Food & Nutr Sci, Dept Food Sci & Human Nutr, Lab Dietet & Qual Life, Athens 11855, Greece.
   [Siasos, Gerasimos] Natl & Kapodistrian Univ Athens, Sotiria Thorac Dis Gen Hosp, Med Sch, Dept Cardiol 3, Athens 11527, Greece.
   [Kassi, Eva] Natl & Kapodistrian Univ Athens, Laiko Gen Hosp, Med Sch, Dept Propaedeut Internal Med 1,Endocrine Unit, Athens 11527, Greece.
C3 National & Kapodistrian University of Athens; National & Kapodistrian
   University of Athens; University of Warwick; University of Warwick;
   Agricultural University of Athens; National & Kapodistrian University of
   Athens; National & Kapodistrian University of Athens; Laiko General
   Hospital
RP Kassi, E; Papavassiliou, AG (corresponding author), Natl & Kapodistrian Univ Athens, Med Sch, Dept Biol Chem, Athens 11527, Greece.; Kassi, E (corresponding author), Natl & Kapodistrian Univ Athens, Laiko Gen Hosp, Med Sch, Dept Propaedeut Internal Med 1,Endocrine Unit, Athens 11527, Greece.
EM ekassi@med.uoa.gr; papavas@med.uoa.gr
RI Siasos, Gerasimos/AAD-7218-2019; Androutsakos, Theodoros/AAF-5209-2020
OI Siasos, Gerasimos/0000-0001-7601-8870; Androutsakos,
   Theodoros/0000-0003-2556-6230; FLESSA,
   CHRISTINA-MARIA/0000-0003-2915-6386; Papavassiliou,
   Athanasios/0000-0001-5803-4527
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NR 238
TC 65
Z9 68
U1 4
U2 26
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2073-4409
J9 CELLS-BASEL
JI Cells
PD AUG
PY 2022
VL 11
IS 16
AR 2511
DI 10.3390/cells11162511
PG 32
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA 4D5UQ
UT WOS:000847206000001
PM 36010588
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Song, JH
   Pan, C
   Li, FF
   Guo, Y
   Pei, P
   Tian, XC
   Wang, SJ
   Gao, RQ
   Pang, ZC
   Chen, ZM
   Li, LM
AF Song, Jiahui
   Pan, Chi
   Li, Feifei
   Guo, Yu
   Pei, Pei
   Tian, Xiaocao
   Wang, Shaojie
   Gao, Ruqin
   Pang, Zengchang
   Chen, Zhengming
   Li, Liming
TI Association between dairy consumption and ischemic heart disease among
   Chinese adults: a prospective study in Qingdao
SO NUTRITION & METABOLISM
LA English
DT Article
DE China; Prospective study; Dairy; Ischemic heart disease
ID SELF-REPORTED SMOKING; METABOLIC SYNDROME; CARDIOVASCULAR-DISEASES;
   PROSPECTIVE COHORT; OXIDATIVE STRESS; FULL-FAT; PRODUCTS; MORTALITY;
   RISK; MILK
AB Background Previous studies linking dairy consumption with ischemic heart disease (IHD) are almost from western countries, with little from China. The present study was to explore the relationship between dairy consumption and IHD among Chinese adults. Methods The data for the present study was from the prospective cohort study of China Kadoorie Biobank in Qingdao, a total of 33,355 participants in the present study. An interviewer-administered laptop-based questionnaire was used to collect information on the consumption frequency of dairy, incident IHD cases were identified through Disease Surveillance Point System and the new national health insurance databases. Cox regression analyses were performed to estimate adjusted hazard ratios (HRs) and confidence interval for the relationship between the incidence of IHD and dairy consumption. Results The baseline survey reported that 32.4% of males and 34.6% of females consumed dairy regularly (i.e. >= 4 days/week). Over an average of 9.2 years follow-up, 2712 new-onset IHD were documented. Compared with participants who never or rarely consume dairy, the HR of consumed dairy regularly was 0.85(0.73-0.98) for males (P < 0.05), while no significant benefits were identified for females. Conclusions Regular dairy consumption had an inverse association to the onset of IHD among males, with no similar findings for females.
C1 [Song, Jiahui; Pan, Chi] Qingdao Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Qingdao 266071, Peoples R China.
   [Li, Feifei; Tian, Xiaocao; Wang, Shaojie; Gao, Ruqin; Pang, Zengchang] Qingdao Municipal Ctr Dis Control & Prevent, Qingdao 266033, Peoples R China.
   [Li, Feifei; Tian, Xiaocao; Wang, Shaojie; Gao, Ruqin; Pang, Zengchang] Qingdao Inst Prevent Med, Qingdao 266033, Peoples R China.
   [Guo, Yu; Pei, Pei] Chinese Acad Med Sci, Beijing 100730, Peoples R China.
   [Chen, Zhengming] Univ Oxford, Nuffield Dept Populat Hlth, Clin Trial Serv Unit & Epidemiol Studies Unit CTS, Oxford, England.
   [Li, Liming] Peking Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Hlth Sci Ctr, Beijing 100191, Peoples R China.
C3 Qingdao University; Chinese Academy of Medical Sciences - Peking Union
   Medical College; University of Oxford; Peking University
RP Tian, XC; Gao, RQ (corresponding author), Qingdao Municipal Ctr Dis Control & Prevent, Qingdao 266033, Peoples R China.; Tian, XC; Gao, RQ (corresponding author), Qingdao Inst Prevent Med, Qingdao 266033, Peoples R China.
EM txc_2006911@126.com; gaoruqin@sohu.com
RI Chen, Zhengming/JQW-0084-2023; Li, Feifei/JTT-8011-2023
OI Tian, Xiaocao/0000-0002-4275-3719
FU National Key Research and Development Program of China [2016YFC0900500,
   2016YFC0900501, 2016YFC0900504]; Kadoorie Charitable Foundation in Hong
   Kong [088158/Z/09/Z, 104085/Z/14/Z]; Wellcome Trust in the UK; Qingdao
   Outstanding Health Professional Development Fund
FX This work was supported by grants (2016YFC0900500, 2016YFC0900501,
   2016YFC0900504) from the National Key Research and Development Program
   of China, grants from the Kadoorie Charitable Foundation in Hong Kong
   and grants (088158/Z/09/Z, 104085/Z/14/Z) from Wellcome Trust in the UK.
   The work also supported by Qingdao Outstanding Health Professional
   Development Fund.
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NR 52
TC 2
Z9 2
U1 1
U2 11
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1743-7075
J9 NUTR METAB
JI Nutr. Metab.
PD FEB 19
PY 2022
VL 19
IS 1
AR 11
DI 10.1186/s12986-022-00645-9
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA ZD6OW
UT WOS:000758318100001
PM 35183210
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Barros, RBD
   Alvim-Silva, T
   de Souza, JRN
   Marques, EB
   Rocha, NN
   Brito, FCF
   Scaramello, CBV
AF de Magalhaes Barros, Rogerio Barbosa
   Alvim-Silva, Thais
   Nunes de Souza, Julia Raquel
   Marques, Emiliana Barbosa
   Rocha, Nazareth N.
   Brito, Fernanda C. F.
   Scaramello, Christianne B., V
TI Biometric, nutritional, biochemical, and cardiovascular outcomes in male
   rats submitted to an experimental model of early weaning that mimics
   mother abandoning
SO JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE
LA English
DT Article
DE Weaning; infant nutrition disorders; adaptation; physiological;
   cardiovascular diseases
ID DENSITY-LIPOPROTEIN CHOLESTEROL; PROLACTIN INHIBITION; LACTATION
   PROGRAMS; METABOLIC SYNDROME; DIASTOLIC FUNCTION; LEPTIN RESISTANCE;
   EUROPEAN-SOCIETY; BLOOD-PRESSURE; ASSOCIATION; GUIDELINES
AB Literature describes breast milk as the best food for the newborn, recommending exclusive breastfeeding for up to 6 months of age. However, it is not available for more than 40% of children worldwide. Pharmacological and non-pharmacological models of 3-day early weaning were developed in rodents to investigate later outcomes related solely to this nutritional insult. Thus, the present work aimed to describe biometric, nutritional, biochemical, and cardiovascular outcomes in adult male rats submitted to 3-day early weaning achieved by maternal deprivation. This experimental model comprises not only nutritional insult but also emotional stress, simulating mother abandoning. Male offspring were physically separated from their mothers at 21st (control) or 18th (early weaning) postnatal day, receiving water/food ad libitum. Analysis performed at postnatal days 30, 90, 150, and 365 encompassed body mass and food intake monitoring and serum biochemistry determination. Further assessments included hemodynamic, echocardiographic, and cardiorespiratory evaluation. Early-weaned males presented higher body weight when compared to control as well as dyslipidemia, higher blood pressure, diastolic dysfunction, and cardiac hypertrophy in adult life. Animals early deprived of their mothers have also presented a worse performance on the maximal effort ergometer test. This work shows that 3-day early maternal deprivation favors the development of cardiovascular disease in male rats.
C1 [de Magalhaes Barros, Rogerio Barbosa; Alvim-Silva, Thais; Nunes de Souza, Julia Raquel; Marques, Emiliana Barbosa; Rocha, Nazareth N.; Brito, Fernanda C. F.; Scaramello, Christianne B., V] Fluminense Fed Univ, Rio De Janeiro, Brazil.
C3 Universidade Federal Fluminense
RP Scaramello, CBV (corresponding author), Fluminense Fed Univ, Rua Prof Hernani Pires de Melo 101,Sala 204A, BR-24210130 Niteroi, RJ, Brazil.
EM chrisbretas@gmail.com
RI Scaramello, Christianne/AAJ-1434-2021; brito, fernanda/AAL-8474-2021;
   Bretas, Christianne/C-7837-2017
OI Reis, AlessanRSS/0000-0001-8486-7469; Bretas,
   Christianne/0000-0003-0388-2208
FU FAPERJ; CAPES; CNPq
FX The authors thank FAPERJ, CAPES, and CNPq for the financial support.
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NR 54
TC 0
Z9 0
U1 1
U2 5
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 2040-1744
EI 2040-1752
J9 J DEV ORIG HLTH DIS
JI J. Dev. Orig. Health Dis.
PD JUN
PY 2021
VL 12
IS 3
BP 523
EP 529
AR PII S2040174420000793
DI 10.1017/S2040174420000793
PG 7
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA SD1PS
UT WOS:000651139800021
PM 32900421
DA 2025-06-11
ER

PT J
AU Zhu, HL
   Liu, SX
   Yao, LL
   Wang, L
   Li, CF
AF Zhu, Huilan
   Liu, Sixin
   Yao, Linling
   Wang, Lu
   Li, Congfa
TI Free and Bound Phenolics of Buckwheat Varieties: HPLC Characterization,
   Antioxidant Activity, and Inhibitory Potency towards α-Glucosidase with
   Molecular Docking Analysis
SO ANTIOXIDANTS
LA English
DT Article
DE buckwheat varieties; free phenolic; bound phenolic; antioxidant
   activity; alpha-glucosidase inhibitory activity; molecular docking
ID TARTARY BUCKWHEAT; IN-VITRO; PHYTOCHEMICAL COMPOSITIONS; METABOLIC
   SYNDROME; FLAVONOIDS CONTENT; OXIDATIVE STRESS; DYSFUNCTION; GENOTYPE;
   CAPACITY; OBESITY
AB Free and bound phenolic fractions from six buckwheat varieties were investigated for their compositions, antioxidant activities, and inhibitory effects on alpha-glucosidase. The results showed that different buckwheat varieties have significant differences in phenolic/flavonoid contents, and these contents were found in higher quantities in free form than in bound form. HPLC results revealed that rutin, quercetin, and kaempferol-3-O-rutinoside were the most abundant components in free and bound forms, whereas dihydromyricetin was found only in the bound form. Free phenolics showed higher antioxidant activities of DPPH, ABTS(+), OH center dot, and FRAP than those of bound phenolics. Strong inhibitory effects against alpha-glucosidase by the free/bound phenolic fractions were found in all buckwheat varieties, and free phenolics showed stronger alpha-glucosidase inhibition than that of the corresponding bound phenolics. More importantly, the main phenolic compounds observed in the buckwheat varieties were subjected to molecular docking analysis to provide insight into their interactions with alpha-glucosidase. The contributions by individual phenolics to the observed variation was analysed by Pearson correlation coefficient analysis and principal component analysis. The present study provides a comprehensive comparison for the phenolic fractions of buckwheat varieties and identify the main contributors to antioxidant and alpha-glucosidase inhibitory activity.
C1 [Zhu, Huilan; Liu, Sixin; Yao, Linling; Wang, Lu; Li, Congfa] Hainan Univ, Coll Food Sci & Engn, Haikou 570228, Hainan, Peoples R China.
C3 Hainan University
RP Wang, L; Li, CF (corresponding author), Hainan Univ, Coll Food Sci & Engn, Haikou 570228, Hainan, Peoples R China.
EM 13016276276@139.com; sixinliu@126.com; Yaoll955@163.com;
   lwang@hainanu.edu.cn; congfa@vip.163.com
RI Li, Congfa/GZG-3161-2022; li, wu/AAG-2304-2020
FU Scientific Research Foundation of Hainan University [KYQD1901]; Funding
   for the Construction of World First Class Discipline of Hainan
   University [RZZX201915]
FX This work was supported by the Scientific Research Foundation of Hainan
   University (no. KYQD1901) and the Funding for the Construction of World
   First Class Discipline of Hainan University (no. RZZX201915).
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NR 43
TC 44
Z9 46
U1 4
U2 48
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD DEC
PY 2019
VL 8
IS 12
AR 606
DI 10.3390/antiox8120606
PG 16
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA KB6WN
UT WOS:000506633000039
PM 31795516
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Pacifico, L
   Osborn, JF
   Bonci, E
   Pierimarchi, P
   Chiesa, C
AF Pacifico, Lucia
   Osborn, John F.
   Bonci, Enea
   Pierimarchi, Pasquale
   Chiesa, Claudio
TI Association between Vitamin D Levels and Nonalcoholic Fatty Liver
   Disease: Potential Confounding Variables
SO MINI-REVIEWS IN MEDICINAL CHEMISTRY
LA English
DT Review
DE 25-hydroxyvitamin D; nonalcoholic fatty liver disease; nonalcoholic
   steatohepatitis; obesity; vitamin D deficiency; liquid chromatography
   tandem mass spectrometry; supplementation
ID 25-HYDROXYVITAMIN D LEVELS; BONE-MINERAL DENSITY; D-BINDING PROTEIN;
   PARATHYROID-HORMONE CONCENTRATIONS; MORBIDLY OBESE-PATIENTS; D
   DEFICIENCY; D INSUFFICIENCY; HYPOVITAMINOSIS-D; D ASSAYS; LIFE-STYLE
AB Nonalcoholic fatty liver disease (NAFLD), historically considered to be the hepatic component of the metabolic syndrome, is a spectrum of fat-associated liver conditions, in the absence of secondary causes, that may progress to nonalcoholic steatohepatitis (NASH), fibrosis, and cirrhosis. Disease progression is closely associated with body weight or fatness, dyslipidemia, insulin resistance, oxidative stress, and inflammation. Recently, vitamin D deficiency has been linked to the pathogenesis and severity of NAFLD because of vitamin D "pleiotropic" functions, with roles in immune modulation, cell differentiation and proliferation, and regulation of inflammation. Indeed, several studies have reported an association between vitamin D and NAFLD/NASH. However, other studies have failed to find an association. Therefore, we sought to critically review the current evidence on the association between vitamin D deficiency and NAFLD/NASH, and to analyze and discuss some key variables that may interfere with this evaluation, such as host-, environment-, and heritability-related factors regulating vitamin D synthesis and metabolism; definitions of deficient or optimal vitamin D status with respect to skeletal and nonskeletal outcomes including NAFLD/NASH; methods of measuring 25(OH)D; and methods of diagnosing NAFLD as well as quantifying adiposity, the cardinal link between vitamin D deficiency and NAFLD.
C1 [Pacifico, Lucia] Sapienza Univ Rome, Policlin Umberto I Hosp, Viale Regina Elena 324, I-00161 Rome, Italy.
   [Osborn, John F.] Sapienza Univ Rome, Dept Publ Hlth & Infect Dis, Viale Regina Elena 324, I-00161 Rome, Italy.
   [Bonci, Enea] Sapienza Univ Rome, Dept Expt Med, Viale Regina Elena 324, I-00161 Rome, Italy.
   [Pierimarchi, Pasquale; Chiesa, Claudio] CNR, Inst Translat Pharmacol, Via Fosso del Cavaliere 100, I-00133 Rome, Italy.
C3 Sapienza University Rome; University Hospital Sapienza Rome; Sapienza
   University Rome; Sapienza University Rome; Consiglio Nazionale delle
   Ricerche (CNR); Istituto di Farmacologia Traslazionale (IFT-CNR)
RP Chiesa, C (corresponding author), CNR, Inst Translat Pharmacol, Via Fosso del Cavaliere 100, I-00133 Rome, Italy.
EM claudio.chiesa@ift.cnr.it
RI Pacifico, Lucia/S-4662-2019; Pierimarchi, Pasquale/AAX-2833-2020
OI Bonci, Enea/0000-0003-3325-1124
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NR 223
TC 37
Z9 39
U1 0
U2 10
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1389-5575
EI 1875-5607
J9 MINI-REV MED CHEM
JI Mini-Rev. Med. Chem.
PY 2019
VL 19
IS 4
BP 310
EP 332
DI 10.2174/1389557518666181025153712
PG 23
WC Chemistry, Medicinal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA HJ3VE
UT WOS:000457101100004
PM 30360708
OA hybrid
DA 2025-06-11
ER

PT J
AU Hostinar, CE
   Ross, KM
   Chan, M
   Chen, E
   Miller, GE
AF Hostinar, Camelia E.
   Ross, Kharah M.
   Chan, Meanne
   Chen, Edith
   Miller, Gregory E.
TI Threat vigilance and socioeconomic disparities in metabolic health
SO DEVELOPMENT AND PSYCHOPATHOLOGY
LA English
DT Article
ID CARDIOVASCULAR-DISEASE RISK; LIFE-COURSE ORIGINS; NUTRITION EXAMINATION;
   COGNITIVE APPRAISAL; CHILDHOOD POVERTY; AFRICAN-AMERICAN; ALLOSTATIC
   LOAD; NATIONAL-HEALTH; STRESS; OBESITY
AB A quarter of the global population meets diagnostic criteria for metabolic syndrome (MetS). MetS prevalence stratifies by socioeconomic status (SES), such that low SES is associated with higher MetS risk starting in childhood. Despite this trend, some low-SES children maintain good metabolic health across the life span, but the factors responsible for their resilience are not well understood. This study examined the role of threat vigilance as either a moderator or a mediator of the effects of low early life SES on adult metabolic risk. Three hundred twenty-five Canadians aged 15-55 participated (M = 36.4 years, SD = 10.7; 55.4% female). We coded parental occupational status between the ages of 0 and 5 to index early life SES. We used the International Diabetes Federation case definition for MetS based on waist circumference, blood pressure, triglyceride levels, HDL cholesterol, and glycosylated hemoglobin measures. Threat vigilance was assessed using the Weapons Identification Procedure, a visual discrimination paradigm that captures implicit perceptions of threat. Analyses supported the moderator hypothesis: low early life SES was associated with MetS diagnosis exclusively among those with high levels of threat vigilance. This suggests that low early life SES environments that heighten vigilance to threat might be particularly detrimental for metabolic health. Conversely, low threat vigilance may buffer against the metabolic risks associated with socioeconomic disadvantage.
C1 [Hostinar, Camelia E.] Univ Calif Davis, Davis, CA 95618 USA.
   [Ross, Kharah M.] Univ Calif Los Angeles, Los Angeles, CA 90024 USA.
   [Chan, Meanne] Univ Toronto, Toronto, ON, Canada.
   [Chen, Edith; Miller, Gregory E.] Northwestern Univ, Evanston, IL 60208 USA.
C3 University of California System; University of California Davis;
   University of California System; University of California Los Angeles;
   University of Toronto; Northwestern University
RP Hostinar, CE (corresponding author), Univ Calif Davis, Dept Psychol, 202 Cousteau Pl, Davis, CA 95618 USA.
EM cehostinar@ucdavis.edu
RI ; Ross, Kharah/M-1453-2016
OI Miller, Gregory/0000-0002-7217-1082; Chan, Meanne/0000-0001-7074-7351;
   Ross, Kharah/0000-0002-1472-5630
FU NIH [R01 HD058502, F32 HD078048]
FX We thank the participants for their contribution to this project. This
   research was supported by NIH Grants R01 HD058502 and F32 HD078048.
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NR 88
TC 6
Z9 10
U1 0
U2 8
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
SN 0954-5794
EI 1469-2198
J9 DEV PSYCHOPATHOL
JI Dev. Psychopathol.
PD DEC
PY 2017
VL 29
IS 5
SI SI
BP 1721
EP 1733
DI 10.1017/S0954579417001353
PG 13
WC Psychology, Developmental
WE Social Science Citation Index (SSCI)
SC Psychology
GA FX3EF
UT WOS:000425952800015
PM 29162180
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Lohr, M
   Jensen, A
   Eriksen, L
   Gronbæk, M
   Loft, S
   Moller, P
AF Lohr, Mille
   Jensen, Annie
   Eriksen, Louise
   Gronbaek, Morten
   Loft, Steffen
   Moller, Peter
TI Association between age and repair of oxidatively damaged DNA in human
   peripheral blood mononuclear cells
SO MUTAGENESIS
LA English
DT Article
ID ASSAY VALIDATION GROUP; COMET ASSAY; LUNG-CANCER; METABOLIC SYNDROME;
   8-OXO-7,8-DIHYDRO-2'-DEOXYGUANOSINE EXCRETION; ANTIOXIDANT PROTECTION;
   OCCUPATIONAL-EXPOSURE; INCISION ACTIVITY; EXCISION-REPAIR; MINERAL
   FIBERS
AB It has been hypothesised that positive associations between age and levels of oxidative stress-generated damage to DNA may be related to an age-dependent decline in DNA repair activity. The objective of this study was to investigate the association between age and repair activity of oxidatively damaged DNA in peripheral blood mononuclear cells (PBMCs). We isolated PBMCs from subjects aged 18-83 years, as part of a health survey of the Danish population that focussed on lifestyle factors. The level of DNA repair activity was measured as incisions on potassium bromate-damaged DNA by the comet assay. There was an inverse association between age and DNA repair activity with a 0.65% decline in activity per year from age 18 to 83 (95% confidence interval: 0.16-1.14% per year). Univariate regression analysis also indicated inverse associations between DNA repair activity and waist-hip ratio (P < 0.05) and plasma concentrations of glycosylated hemoglobin (P = 0.07). However, multivariate regression analysis only showed an inverse association between age and DNA repair activity (P < 0.05), indicating that the decline in repair activity was not mediated by metabolic risk factors. In summary, the results show an inverse association between age and DNA repair activity of oxidatively damaged DNA.
C1 [Lohr, Mille; Jensen, Annie; Loft, Steffen; Moller, Peter] Univ Copenhagen, Dept Publ Hlth, Environm Hlth Sect, DK-1014 Copenhagen, Denmark.
   [Eriksen, Louise; Gronbaek, Morten] Univ Southern Denmark, Natl Publ Hlth Inst, DK-1353 Copenhagen K, Denmark.
C3 University of Copenhagen; University of Southern Denmark
RP Moller, P (corresponding author), Univ Copenhagen, Dept Publ Hlth, Environm Hlth Sect, Oster Farimagsgade 5A, DK-1014 Copenhagen, Denmark.
EM pemo@sund.ku.dk
OI Loft, Steffen/0000-0001-9552-8518; Gronbaek, Morten
   Klocker/0000-0002-8473-6474
FU Ingeborg og Leo Dannins Legat for Videnskabelig Forskning
FX This work was supported by a grant from the Ingeborg og Leo Dannins
   Legat for Videnskabelig Forskning.
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NR 55
TC 20
Z9 21
U1 0
U2 2
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0267-8357
EI 1464-3804
J9 MUTAGENESIS
JI Mutagenesis
PD SEP
PY 2015
VL 30
IS 5
BP 695
EP 700
DI 10.1093/mutage/gev031
PG 6
WC Genetics & Heredity; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Genetics & Heredity; Toxicology
GA CX0ON
UT WOS:000365396500011
PM 25925070
OA Bronze
DA 2025-06-11
ER

PT J
AU dos Santos, GA
   Ferreira, MS
   de Oliveira, DN
   de Oliveira, V
   Siqueira-Santos, ES
   Cintra, DEC
   Castilho, RF
   Velloso, LA
   Catharino, RR
AF dos Santos, Gustavo Aparecido
   Ferreira, Monica Siqueira
   de Oliveira, Diogo Noin
   de Oliveira, Vanessa
   Siqueira-Santos, Edilene S.
   Correa Cintra, Dennys Esper
   Castilho, Roger Frigerio
   Velloso, Licio Augusto
   Catharino, Rodrigo Ramos
TI Identification of compounds from high-fat and extra virgin olive
   oil-supplemented diets in whole mouse liver extracts and isolated
   mitochondria using mass spectrometry
SO JOURNAL OF MASS SPECTROMETRY
LA English
DT Article
DE diet; electrospray ionization mass spectrometry; extra virgin olive oil;
   nonalcoholic steatohepatitis; Omics
ID NONALCOHOLIC STEATOHEPATITIS; OXIDATIVE STRESS; INSULIN-RESISTANCE;
   RAT-LIVER; GENE-TRANSCRIPTION; METABOLIC SYNDROME; PHOSPHATIDIC-ACID;
   ADIPOSE-TISSUE; OBESITY; ADULTERATION
AB Nonalcoholic steatohepatitis (NASH) is a fatty liver disorder that could be improved with extra virgin olive oil (EVOO) supplementation in diet. We propose the monitoring, in whole mouse liver extracts and in isolated mitochondria, of the absorption of compounds from three different diets: standard (CT), high-fat (HFD) and high-fat supplemented with EVOO (HFSO). Male mice were submitted to one of the following three diets: CT or HFD for 16 weeks or HFD for 8 weeks followed by additional 8 weeks with HFSO. Following this period, liver was extracted for histological evaluation, mitochondria isolation and mass spectrometry analyses. Diets, liver extracts and Percoll-purified mitochondria were analyzed using ESI-MS and the lipidomics approach. Morphological, histological and spectrometric results indicated a decrease in NASH severity with EVOO supplementation in comparison with animals maintained with HFD. Spectrometric data also demonstrated that some compounds presented on the diets are absorbed by the mitochondria. EVOO was shown to be a potential therapeutic alternative in food for NASH. Our results are in accordance with the proposition that the major factor that influences different responses to diets is their composition - and not only calories - especially when it comes to studies on obesity. Copyright (C) 2015 John Wiley & Sons, Ltd.
C1 [dos Santos, Gustavo Aparecido; Ferreira, Monica Siqueira; de Oliveira, Diogo Noin; Catharino, Rodrigo Ramos] Univ Estadual Campinas, Sch Med Sci, INNOVARE Biomarkers Lab, BR-13083877 Campinas, SP, Brazil.
   [de Oliveira, Vanessa; Correa Cintra, Dennys Esper] Univ Estadual Campinas, Fac Sci Appl, Sport Sci Course, BR-13083877 Campinas, SP, Brazil.
   [Siqueira-Santos, Edilene S.; Castilho, Roger Frigerio] Univ Estadual Campinas, Sch Med Sci, Expt Neurodegenerat Lab, BR-13083877 Campinas, SP, Brazil.
   [Velloso, Licio Augusto] Univ Estadual Campinas, Sch Med Sci, Lab Cell Signaling, BR-13083877 Campinas, SP, Brazil.
C3 Universidade Estadual de Campinas; Universidade Estadual de Campinas;
   Universidade Estadual de Campinas; Universidade Estadual de Campinas
RP Catharino, RR (corresponding author), Univ Estadual Campinas, Sch Pharmaceut Sci, INNOVARE Biomarkers Lab, Rua Cinco Junho 350, BR-13083877 Campinas, SP, Brazil.
EM rrc@fcm.unicamp.br
RI Castilho, Roger/G-3906-2012; Catharino, Rodrigo/AAH-4333-2021; Ferreira,
   Mônica/B-8718-2014; Catharino, Rodrigo/G-1487-2013; Noin de Oliveira,
   Diogo/C-3939-2013
OI Catharino, Rodrigo/0000-0001-7219-2644; Frigerio Castilho,
   Roger/0000-0003-2338-8717; Noin de Oliveira, Diogo/0000-0002-2725-476X
FU FAPESP (Sao Paulo Research Foundation) [2014/00084-2, 2014/23010-4,
   2011/50400-0]; CAPES (Coordination for the Improvement of Higher Level
   or Education Personnel); CNPq; INCT (National Science and Technology
   Institutes); Fundacao de Amparo a Pesquisa do Estado de Sao Paulo
   (FAPESP) [14/00084-2] Funding Source: FAPESP; Formas [2014-00084]
   Funding Source: Formas
FX We would like to thank FAPESP (Sao Paulo Research Foundation,
   2014/00084-2, 2014/23010-4 and 2011/50400-0), CAPES (Coordination for
   the Improvement of Higher Level or Education Personnel), CNPq and INCT
   (National Science and Technology Institutes) for the financial support.
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NR 52
TC 7
Z9 7
U1 0
U2 12
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1076-5174
EI 1096-9888
J9 J MASS SPECTROM
JI J. Mass Spectrom.
PD JUL
PY 2015
VL 50
IS 7
BP 951
EP 958
DI 10.1002/jms.3609
PG 8
WC Biochemical Research Methods; Chemistry, Analytical; Spectroscopy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry; Spectroscopy
GA CO6NK
UT WOS:000359273200011
PM 26349651
DA 2025-06-11
ER

PT J
AU Ceriello, A
   Sportiello, L
   Rafaniello, C
   Rossi, F
AF Ceriello, Antonio
   Sportiello, Liberata
   Rafaniello, Concetta
   Rossi, Francesco
TI DPP-4 inhibitors: pharmacological differences and their clinical
   implications
SO EXPERT OPINION ON DRUG SAFETY
LA English
DT Review
DE dipeptidyl peptidase-4 inhibitors; glucose variability;
   pharmacodynamics; pharmacokinetics; pharmacology; type 2 diabetes
ID DIPEPTIDYL PEPTIDASE-4 INHIBITORS; TYPE-2 DIABETES-MELLITUS;
   GLUCAGON-LIKE PEPTIDE-1; ACUTE GLUCOSE FLUCTUATIONS; OXIDATIVE STRESS;
   METABOLIC SYNDROME; GLYCEMIC VARIABILITY; RECEPTOR AGONISTS; ADD-ON;
   CARDIOVASCULAR OUTCOMES
AB Introduction: Recently, incretin-based therapy was introduced for the treatment of type 2 diabetes (T2D). In particular, dipeptidyl peptidase-4 inhibitors (DPP-4i) (sitagliptin, vildagliptin, saxagliptin, linagliptin and alogliptin) play an increasing role in the management of T2D.
   Areas covered: An extensive literature search was performed to analyze the pharmacological characteristics of DPP-4i and their clinical implications.
   Expert opinion: DPP-4i present significant pharmacokinetic differences. They also differ in chemical structure, in the interaction with distinct subsites of the enzyme and in different levels of selectivity and potency of enzyme inhibition. Moreover, disparities in the effects on glycated hemoglobin, glucagon-like peptide-1 and glucagon levels and on glucose variability have been observed. However, indirect comparisons indicate that all DPP-4i have a similar safety and efficacy profiles. DPP-4i are preferred in overweight/obese and elderly patients because of the advantages of minimal or no influence on weight gain and low risk of hypoglycemia. For the same reasons, DPP-4i can be safely combined with insulin. However, currently cardiovascular outcomes related to DPP-4i are widely debated and the available evidence is controversial. Today, long-term studies are still in progress and upcoming results will allow us to better define the strengths and limits of this therapeutic class.
C1 [Ceriello, Antonio] Hosp Clin Barcelona, Inst Invest Biomed August Pi I Sunyer IDIBAPS, Dept Endocrinol, Barcelona, Spain.
   [Sportiello, Liberata; Rafaniello, Concetta; Rossi, Francesco] Univ Naples 2, Reg Ctr Pharmacovigilance & Pharmacoepidemiol, Dept Expt Med, Sect Pharmacol L Donatelli, I-80138 Naples, Italy.
C3 University of Barcelona; Hospital Clinic de Barcelona; IDIBAPS;
   Universita della Campania Vanvitelli
RP Rossi, F (corresponding author), Univ Naples 2, Reg Ctr Pharmacovigilance & Pharmacoepidemiol, Dept Expt Med, Sect Pharmacol L Donatelli, Via Costantinopoli 16, I-80138 Naples, Italy.
EM francesco.rossi@unina2.it
RI Ceriello, Antonio/J-9575-2016
OI RAFANIELLO, Concetta/0000-0002-7107-4280; Ceriello,
   Antonio/0000-0001-8122-3203; Sportiello, Liberata/0000-0002-5884-9889
FU Second University of Naples; Novartis
FX A Ceriello and F Rossi have received honoraria from Novartis. The paper
   is part of a themed issue funded by the authors' institution, the Second
   University of Naples and received additional funding from Novartis. The
   authors have no relevant affiliations or financial involvement with any
   organization or entity with a financial interest in or financial
   conflict with the subject matter or materials discussed in the
   manuscript. This includes employment, consultancies, honoraria, stock
   ownership or options, expert testimony, grants or patents received or
   pending, or royalties.
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NR 101
TC 52
Z9 58
U1 0
U2 26
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1474-0338
EI 1744-764X
J9 EXPERT OPIN DRUG SAF
JI Expert Opin. Drug Saf.
PD SEP
PY 2014
VL 13
SU 1
BP S57
EP S68
DI 10.1517/14740338.2014.944862
PG 12
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA AO4JJ
UT WOS:000341303100006
PM 25171159
DA 2025-06-11
ER

PT J
AU Niemelä, O
   Alatalo, P
AF Niemela, Onni
   Alatalo, Paivikki
TI Biomarkers of alcohol consumption and related liver disease
SO SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION
LA English
DT Review
DE Aminotransferase; CDT; ethanol; fibrosis; GGT; NASH; obesity
ID GAMMA-GLUTAMYL-TRANSFERASE; CARBOHYDRATE-DEFICIENT TRANSFERRIN; SERUM
   ALANINE AMINOTRANSFERASE; UNITED-STATES POPULATION; URINARY ETHYL
   GLUCURONIDE; BODY-MASS INDEX; HEAVY DRINKERS; NONALCOHOLIC
   STEATOHEPATITIS; CARDIOVASCULAR-DISEASE; MODERATE DRINKING
AB Alcohol abuse is a major cause of abnormal liver function throughout the world. While measurements of liver enzyme activities (GGT, ALT, AST) are important screening tools for detecting liver disease, due to lack of ethanol-specificity and inconsistencies regarding the definitions of significant alcohol consumption, several other blood tests are usually needed to exclude competing and co-existing causes of abnormal liver function. Information on the specific role of ethanol consumption behind hepatotoxicity may be obtained through measurements of blood ethanol and its specific metabolites (ethyl glucuronide, phosphatidylethanol, protein-acetaldehyde condensates and associated autoimmune responses). Recent studies have indicated that being overweight is another increasingly common cause of abnormal liver enzyme levels and adiposity may also increase the impact of ethanol consumption on liver pathology. Interestingly, increased liver enzyme activities in circulation may reflect not only hepatic function but can also serve as indicators of general health and the status of oxidative stress in vivo. ALT and GGT activities predict insulin resistance, metabolic syndrome, mortality from coronary heart diseases and even mortality from all causes. If the upper reference limits for liver enzyme activities were defined based on the data obtained from normal weight abstainers, the clinical value of liver enzyme measurements as screening tools and in patient follow-up could be significantly improved.
C1 [Niemela, Onni] Seinajoki Cent Hosp, Dept Lab Med, FIN-60220 Seinajoki, Finland.
   Seinajoki Cent Hosp, Med Res Unit, FIN-60220 Seinajoki, Finland.
   Univ Tampere, Seinajoki, Finland.
C3 Seinajoki Central Hospital; Seinajoki Central Hospital; Tampere
   University
RP Niemelä, O (corresponding author), Seinajoki Cent Hosp, Dept Lab Med, FIN-60220 Seinajoki, Finland.
EM onni.niemela@epshp.fi
RI Kangastupa, Päivikki/JZZ-0468-2024
OI Kangastupa, Paivikki/0000-0003-0695-6073
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NR 72
TC 78
Z9 83
U1 1
U2 23
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0036-5513
EI 1502-7686
J9 SCAND J CLIN LAB INV
JI Scand. J. Clin. Lab. Invest.
PY 2010
VL 70
IS 5
BP 305
EP 312
DI 10.3109/00365513.2010.486442
PG 8
WC Medical Laboratory Technology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology; Research & Experimental Medicine
GA 654RP
UT WOS:000282186000001
PM 20470213
DA 2025-06-11
ER

PT J
AU Ubaldo-Reyes, LM
   Espitia-Bautista, E
   Barajas-Martínez, A
   Martínez-Tapia, R
   Rodríguez-Mata, V
   Noriega-Navarro, R
   Escalona, R
   Castillo-Hernández, J
   Pérez-Torres, A
   Navarro, L
AF Ubaldo-Reyes, Laura M.
   Espitia-Bautista, Estefania
   Barajas-Martinez, Antonio
   Martinez-Tapia, Ricardo
   Rodriguez-Mata, Veronica
   Noriega-Navarro, Roxana
   Escalona, Rene
   Castillo-Hernandez, Jesus
   Perez-Torres, Armando
   Navarro, Luz
TI High-Fat Diet-Induced Blood-Brain Barrier Dysfunction: Impact on
   Allodynia and Motor Coordination in Rats
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE neuroimmunology; nociception; neuronal integrity; motor impairment;
   high-fat diet
ID ENDOPLASMIC-RETICULUM STRESS; OBESITY; SENSITIVITY; IMPAIRMENT;
   RESISTANCE; MODELS; MICE
AB The associations among increased pain sensitivity, obesity, and systemic inflammation have not been described as related to BBB dysfunctions. To analyze the metabolic, behavioral, and inflammatory effects of a high-fat diet (HFD) and ultrastructural modifications in brain regions, we used an in vivo experimental model. Adult male Wistar rats were randomly assigned to one of two conditions, an ad libitum control group or an HFD (60%)-fed group, for eight weeks. At the end of the protocol, glucose and insulin tolerance tests were performed. Additionally, we analyzed the response to a normally innocuous mechanical stimulus and changes in motor coordination. At the end of the protocol, HFD-fed rats presented increased HOMA-IR and metabolic syndrome (MetS) prevalence. HFD-fed rats also developed an increased nociceptive response to mechanical stimuli and neurological injury, resulting in impaired motor function. Hypothalamus and cerebellum neurons from HFD-fed rats presented with nuclear swelling, an absence of nucleoli, and karyolysis. These results reveal that HFD consumption affects vital brain structures such as the cerebellum, hippocampus, and hypothalamus. This, in turn, could be producing neuronal damage, impairing cellular communication, and consequently altering motricity and pain sensitivity. Although direct evidence of a causal link between BBB dysfunction and sensory-motor changes was not observed, understanding the association uncovered in this study could lead to targeted therapeutic strategies.
C1 [Ubaldo-Reyes, Laura M.] Univ Nacl Autonoma Mexico, Fac Med, Dept Anat, Mexico City 04510, Mexico.
   [Espitia-Bautista, Estefania] Natl Inst Psychiat Ramon Fuente, Lab Mol Neurophysiol, Mexico City 14370, Mexico.
   [Barajas-Martinez, Antonio] Univ Nacl Autonoma Mexico, Ctr Complex Sci, Mexico City 04510, Mexico.
   [Martinez-Tapia, Ricardo; Noriega-Navarro, Roxana; Navarro, Luz] Univ Nacl Autonoma Mexico, Fac Med, Dept Physiol, Mexico City 04510, Mexico.
   [Rodriguez-Mata, Veronica; Perez-Torres, Armando] Univ Nacl Autonoma Mexico, Fac Med, Dept Histol, Mexico City 04510, Mexico.
   [Escalona, Rene] Univ Nacl Autonoma Mexico, Fac Med, Lab Embryol & Genet, Dept Embriol & Genet, Mexico City 04510, Mexico.
   [Castillo-Hernandez, Jesus] Autonomous Univ San Luis Potosi, Multidisciplinary Acad Unit Zona Media, Multidisciplinary Acad Unit Middle Zone, San Luis Potosi 79615, Mexico.
C3 Universidad Nacional Autonoma de Mexico; Instituto Nacional de
   Psiquiatria Ramon de la Fuente Muniz; Universidad Nacional Autonoma de
   Mexico; Universidad Nacional Autonoma de Mexico; Universidad Nacional
   Autonoma de Mexico; Universidad Nacional Autonoma de Mexico; Universidad
   Autonoma de San Luis Potosi
RP Ubaldo-Reyes, LM (corresponding author), Univ Nacl Autonoma Mexico, Fac Med, Dept Anat, Mexico City 04510, Mexico.
EM lm.ubaldo@facmed.unam.mx; estefaneb@hotmail.com;
   antonio.barajas@c3.unam.mx; ricardo.mtapia@gmail.com;
   verohistologabct@hotmail.com; roxnn77@gmail.com;
   escalonarj@facmed.unam.mx; jesus.castillo@uaslp.mx; armandop@unam.mx;
   lnavarro@unam.mx
RI Martinez-Tapia, Ricardo/AAU-4219-2020; Navarro, Luz/Q-9086-2019; ubaldo,
   laura/AAE-1776-2020; Barajas-Martinez, Antonio/GLR-1196-2022
OI CASTILLO-HERNANDEZ, JESUS RAMON/0000-0001-7639-2694; Escalona, Jose
   Rene/0000-0001-6559-6712; Perez-Torres, Armando/0000-0003-2519-7922;
   Noriega-Navarro, Roxana/0000-0003-4724-569X; Navarro,
   Luz/0000-0002-5519-0871; Barajas-Martinez, Antonio/0000-0002-5299-0259;
   UBALDO, LAURA/0000-0001-9641-4539
FU Programa de Apoyo a Proyectos de Investigacion e Innovacion Tecnologica
   (PAPIIT); Division de Investigacion Facultad de Medicina, UNAM
   [FMED/DI/067/2019]
FX This research was supported by Programa de Apoyo a Proyectos de
   Investigacion e Innovacion Tecnologica (PAPIIT), grant number IA207321.
   Additionally, we thank the Division de Investigacion Facultad de
   Medicina, UNAM, for supporting this project via FMED/DI/067/2019.
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NR 56
TC 0
Z9 0
U1 1
U2 2
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD OCT
PY 2024
VL 25
IS 20
AR 11218
DI 10.3390/ijms252011218
PG 17
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA K1Q9B
UT WOS:001341707500001
PM 39457000
OA gold
DA 2025-06-11
ER

PT J
AU Sakaguchi, M
AF Sakaguchi, Masaji
TI The role of insulin signaling with FOXO and FOXK transcription factors
SO ENDOCRINE JOURNAL
LA English
DT Article
DE Insulin signaling; Insulin receptor; FoxK1; FoxK2; alpha 4
ID MICE LACKING; LIFE-SPAN; RECEPTOR; SENSITIVITY; EXPRESSION; RESISTANCE;
   PROTEINS; COMPLEX; ABSENCE; IRS-1
AB Insulin is an essential hormone for animal activity and survival, and it controls the metabolic functions of the entire body. Throughout the evolution of metazoan animals and the development of their brains, a sustainable energy supply has been essential to overcoming the competition for survival under various environmental stresses. Managing energy for metabolism, preservation, and consumption inevitably involves high oxidative stress, causing tissue damage in various organs. In both mice and humans, excessive dietary intake can lead to insulin resistance in various organs, ultimately displaying metabolic syndrome and type 2 diabetes. Insulin signals require thorough regulation to maintain metabolism across diverse environments. Recent studies demonstrated that two types of forkhead-box family transcription factors, FOXOs and FOXKs, are related to the switching of insulin signals during fasting and feeding states. Insulin signaling plays a role in supporting higher activity during periods of sufficient food supply and in promoting survival during times of insufficient food supply. The insulin receptor depends on the tyrosine phosphatase feedback of insulin signaling to maintain adipocyte insulin responsiveness. alpha 4, a regulatory subunit of protein phosphatase 2A (PP2A), has been shown to play a crucial role in modulating insulin signaling pathways by regulating the phosphorylation status of key proteins involved in these pathways. This short review summarizes the current understanding of the molecular mechanism related to the regulation of insulin signals.
C1 [Sakaguchi, Masaji] Kumamoto Univ, Fac Life Sci, Dept Metab Med, 1-1-1 Honjo,Chuo Ku, Kumamoto 8608556, Japan.
C3 Kumamoto University
RP Sakaguchi, M (corresponding author), Kumamoto Univ, Fac Life Sci, Dept Metab Med, 1-1-1 Honjo,Chuo Ku, Kumamoto 8608556, Japan.
EM msakaguchi@kumamoto-u.ac.jp
OI Sakaguchi, Masaji/0000-0001-7492-8416
FU JSPS KAKENHI [JP 21K08532]
FX The author was supported by JSPS KAKENHI (JP 21K08532) .
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NR 44
TC 3
Z9 3
U1 2
U2 2
PU JAPAN ENDOCRINE SOC
PI KYOTO
PA THE 6TH FLOOR, TAKAKURA BUILDING, 343-1, SHIJO-CHO, SHIJO
   SHINMACHI-SAGARU, SHIMOGYO-KU, KYOTO, 600-8441, JAPAN
SN 0918-8959
EI 1348-4540
J9 ENDOCR J
JI Endocr. J.
PY 2024
VL 71
IS 10
BP 939
EP 944
DI 10.1507/endocrj.EJ24-0205
EA JUL 2024
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA I1J4W
UT WOS:001266253900001
PM 38987195
OA gold
DA 2025-06-11
ER

PT J
AU Ramírez-Martínez, L
   Palafox-Gómez, C
   Porchia, LM
   López-Bayghen, E
AF Ramirez-Martinez, Leticia
   Palafox-Gomez, Cecilia
   Porchia, Leonardo M.
   Lopez-Bayghen, Esther
TI The Potential for Ketogenic Diets to Control Glucotoxicity,
   Hyperinsulinemia, and Insulin Resistance to Improve Fertility in Women
   with Polycystic Ovary Syndrome
SO CLINICAL AND EXPERIMENTAL OBSTETRICS & GYNECOLOGY
LA English
DT Review
DE diet intervention; fertility; insulin resistance; hyperinsulinemia; PCOS
ID METABOLIC SYNDROME; OXIDATIVE STRESS; LIFE-STYLE; HYPERANDROGENISM;
   DYSFUNCTION; MANAGEMENT; THERAPY; OBESITY; FAT; INFERTILITY
AB Objective: This review aims to summarize the association between insulin resistance (IR) and symptoms of Polycystic Ovary Syndrome (PCOS) while explaining how nutritional interventions, specifically ketogenic diets, help manage PCOS. Mechanism: The effect of IR on diagnostic criteria for PCOS is first described, followed by how a standard diet exacerbates IR. Afterward, nutritional interventions, specifically for women with PCOS, are described. Findings in Brief: IR is associated with ovulatory dysfunction, hyperandrogenism, and polycystic ovarian morphology, which leads to metabolic abnormalities and loss of fertility. Activation of the polyol pathway, advanced glycation end-product accumulation, and hexosamine flux by hyperglycemia and IR are involved in the PCOS phenotypes and reproduction alterations. IR affects oocytes, ovaries, and the endometrium among women with PCOS, leading to infertility. However, nutritional interventions, specifically ketogenic diets, were shown to lower serum cholesterol, triglycerides, androstenedione, testosterone and attenuate IR. At the same time, high-density lipoprotein increased, promoting menstrual regularity and, eventually, providing a better environment for in vitro fertilization. Conclusion: For women with PCOS, managing IR is essential for managing their symptoms and improving fertility. Resolving glucotoxicity caused by excessive dietary glucose with a ketogenic diet is crucial for the prevention and correction of the damage associated with hyperinsulinemia and hyperglycemia, contributing to fertility.
C1 [Ramirez-Martinez, Leticia; Palafox-Gomez, Cecilia; Lopez-Bayghen, Esther] CINVESTAV IPN, Ctr Res & Adv Studies, Dept Toxicol, Mexico City 07360, Mexico.
   [Porchia, Leonardo M.] SC Mexico, Ingenes Infertil & Genet, Mexico City 05320, Mexico.
C3 CINVESTAV - Centro de Investigacion y de Estudios Avanzados del
   Instituto Politecnico Nacional
RP López-Bayghen, E (corresponding author), CINVESTAV IPN, Ctr Res & Adv Studies, Dept Toxicol, Mexico City 07360, Mexico.
RI Lopez-Bayghen, Esther/A-8006-2008
OI Lopez-Bayghen, Esther/0000-0002-2849-7587
FU Consejo Nacional de Humanidades, Ciencia y Tecnologia (Conahcyt)
   [250768, 756245]
FX The study was funded by Consejo Nacional de Humanidades, Ciencia y
   Tecnologia (Conahcyt grant number: 250768 to ELB and the scholarship to
   CPG number 756245) . The funding source had not contributed to the
   manuscript's writing and the decision of where to submit the manuscript
   for publication.
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NR 86
TC 0
Z9 0
U1 3
U2 12
PU IMR PRESS
PI ROBINSON
PA 112 ROBINSON RD, ROBINSON, SINGAPORE
SN 0390-6663
EI 2709-0094
J9 CLIN EXP OBSTET GYN
JI Clin. Exp. Obstet. Gynecol.
PD MAR
PY 2024
VL 51
IS 3
AR 57
DI 10.31083/j.ceog5103057
PG 9
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA MM5R1
UT WOS:001194055900002
OA gold
DA 2025-06-11
ER

PT J
AU Khaleel, FM
   Hassan, EA
   Mohammed, SK
AF Khaleel, Fayhaa M.
   Hassan, Ekhlas Abdallah
   Mohammed, Suhayla Khalied
TI Evaluation of serum zinc in women of childbearing age art its
   relationship with obesity
SO EURASIAN CHEMICAL COMMUNICATIONS
LA English
DT Article
DE Serum zinc; women of childbearing age; obesity; BMI
ID BODY-MASS INDEX; METABOLIC SYNDROME; ASSOCIATION; HYPERANDROGENEMIA;
   OUTCOMES; WEIGHT; RISK
AB Women of childbearing age are prone to gain weight. This article evaluates the levels and range of zinc in overweight or obese women of childbearing age and its relevance with lipid profile, hormones, and other related metabolic parameters. The study group consists of 50 females who did not have heart disease and diabetes and did not subject to the processes of removing the fallopian tube or removing one of the ovaries. Where they were divided into three subgroups (the first normal weight with BMI =(18-24.9), the second overweight BMI=(25-29.9). and the third obese with BMI >= 30. Fasting blood sugar (FBS), lipid profile, level of insulin in fasting, Homeostatic Model Assessment for Insulin Resistance (HOMA IR), Luteinizing hormone (LH), follicle-stimulating hormone (FSH), serum Testosterone, and zinc were performed in all subjects. There was an increase in the insulin level in fasting, HOMA-IR level, and testosterone levels. However, the serum of zinc, FSH, and LH were low when comparing overweight and obesity with normal weight. In summary, there is a major association between zinc levels, obesity, and women of childbearing age. These conclusions promote the hypothesis that increase may be associated with a disturbance of glucose metabolism represented by insulin resistance, dyslipidemia leading to oxidative stress, and finally increase Zn. This association could cause the early development of cardiovascular diseases in females.
C1 [Khaleel, Fayhaa M.] Baghdad Univ, Coll Sci Women, Dept Chem, Baghdad, Iraq.
   [Hassan, Ekhlas Abdallah] Univ Diyala, Coll Sci, Dept Chem, Diyala, Iraq.
   [Mohammed, Suhayla Khalied] Univ Baghdad, Dept Basic Sci, Coll Agr, Baghdad, Iraq.
C3 University of Baghdad; University of Diyala; University of Baghdad
RP Hassan, EA (corresponding author), Univ Diyala, Coll Sci, Dept Chem, Diyala, Iraq.
EM ekhlasbiochemistry@gmail.com
RI mohammed, Suhayla/ACC-5289-2022; Khaleel, Fayhaa/X-3532-2019; Hassan,
   Ekhlas/AGL-2004-2022
OI Khalied, suhayla/0000-0001-5651-1668; Hassan,
   Ekhlas/0000-0001-7655-6230; khaleel, fayhaa m./0000-0002-9951-2086
FU Kamal Al-Samarrai Hospital
FX We appreciate all support and thanks provided by the Kamal Al-Samarrai
   Hospital and by the staff of the Kamal Al-Samarrai Hospital in Baghdad
   city.
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NR 22
TC 0
Z9 0
U1 0
U2 0
PU SAMI PUBLISHING CO-SPC
PI ILAM
PA DANESHJOU BOLV, PO BOX 6931936173, ILAM, 00000, IRAN
SN 2717-0535
EI 2676-6280
J9 EURASIAN CHEM COMMUN
JI Eurasian Chem. Commun.
PD OCT
PY 2022
VL 4
IS 10
BP 950
EP 955
DI 10.22034/ecc.2022.330219.1330
PG 6
WC Chemistry, Multidisciplinary
WE Emerging Sources Citation Index (ESCI)
SC Chemistry
GA 2F2OF
UT WOS:000812752200003
DA 2025-06-11
ER

PT J
AU Faridvand, Y
   Haddadi, P
   Nejabati, HR
   Ghaffari, S
   Zamani-Gharehchamani, E
   Nozari, S
   Nouri, M
   Jodati, A
AF Faridvand, Yousef
   Haddadi, Parinaz
   Nejabati, Hamid Reza
   Ghaffari, Samad
   Zamani-Gharehchamani, Elham
   Nozari, Samira
   Nouri, Mohammad
   Jodati, Ahmadreza
TI Sulforaphane modulates CX3CL1/CX3CR1 axis and inflammation in palmitic
   acid-induced cell injury in C2C12 skeletal muscle cells
SO MOLECULAR BIOLOGY REPORTS
LA English
DT Article
DE Sulforaphane; CX3CL1; Palmitic acid; ROS
ID FRACTALKINE/CX3CR1 SYSTEM; EXERCISE; OVEREXPRESSION; INCREASES; OBESITY;
   CX3CL1; MICE
AB Studies have shown that sulforaphane (SFN) has potent anti-inflammatory and free radical scavenging effects on obesity and associated disorder such as diabetes, polycystic ovary syndrome, and metabolic syndrome. fractalkine (CX3CL1) and its receptor, CX3CR1, play an important role in muscle metabolism by improving insulin-sensitizing effects. Here, in this study we examined the SFN effect on CX3CL1 and its receptor, CX3CR1, in C2C12 myotubes in palmitic acid (PA)-induced oxidative stress and inflammation. The results showed that PA (750 mu M) evoked lipotoxicity as a reduction in cell viability, increased IL-6 and TNF-alpha expression, and enhanced reactive oxygen species (ROS). However, SFN pretreatment attenuated the levels of, IL-6 and TNF-alpha in C2C12 myotubes exposure to PA. Moreover, SFN pretreatment up-regulated nuclear factor erythroid related factor 2 (Nrf2) /heme oxygenase-1(HO-1) pathway protein in C2C12 cells as indicated by a decrease in ROS levels. Interestingly, PA also caused an increase in CX3CL1 and CX3CR1 expression that SFN abrogated it. We also found the protective effect of SFN agonist PA-induced lipotoxicity with promotes in UCP3 gene expression in C2C12 cells. Collectively, these findings suggest that SFN hampers the PA-induced inflammation in C2C12 cells by modulation of the Nrf2/HO-1 pathway and CX3CL1/CX3CR1 axis and may propose a new therapeutic approach to protect against obesity-associated disorders in skeletal muscle cells.
C1 [Faridvand, Yousef; Ghaffari, Samad; Nouri, Mohammad; Jodati, Ahmadreza] Tabriz Univ Med Sci, Cardiovasc Res Ctr, Tabriz, Iran.
   [Faridvand, Yousef; Nejabati, Hamid Reza] Tabriz Univ Med Sci, Dept Biochem & Clin Labs, Fac Med, Tabriz, Iran.
   [Haddadi, Parinaz; Zamani-Gharehchamani, Elham] Tabriz Univ, Dept Biochem, Fac Sci, Tabriz, Iran.
   [Nozari, Samira] Tabriz Univ Med Sci, Student Res Comm, Tabriz, Iran.
   [Nozari, Samira; Nouri, Mohammad] Tabriz Univ Med Sci, Stem Cells Res Ctr, Tabriz, Iran.
   [Nouri, Mohammad] Tabriz Univ Med Sci, Stem Cell & Regenerat Med SCARM Inst, Tabriz, Iran.
C3 Tabriz University of Medical Science; Tabriz University of Medical
   Science; University of Tabriz; Tabriz University of Medical Science;
   Tabriz University of Medical Science; Tabriz University of Medical
   Science
RP Nouri, M; Jodati, A (corresponding author), Tabriz Univ Med Sci, Cardiovasc Res Ctr, Tabriz, Iran.; Nouri, M (corresponding author), Tabriz Univ Med Sci, Stem Cells Res Ctr, Tabriz, Iran.; Nouri, M (corresponding author), Tabriz Univ Med Sci, Stem Cell & Regenerat Med SCARM Inst, Tabriz, Iran.
EM nourimd@yahoo.com; jodati@tbzmed.ac.ir
RI nouri, mohammad/HSB-4293-2023
OI Faridvand, Yousef/0000-0003-1139-3500
FU Student Research Committee, Tabriz University of Medical Sciences,
   Tabriz, Iran
FX The authors thank the Student Research Committee, Tabriz University of
   Medical Sciences, Tabriz, Iran, for all support provided.
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NR 38
TC 9
Z9 9
U1 1
U2 13
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0301-4851
EI 1573-4978
J9 MOL BIOL REP
JI Mol. Biol. Rep.
PD OCT
PY 2020
VL 47
IS 10
BP 7971
EP 7977
DI 10.1007/s11033-020-05875-9
EA OCT 2020
PG 7
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA OK2LZ
UT WOS:000579253100001
PM 33034881
DA 2025-06-11
ER

PT J
AU Chen, ZY
   Ye, LW
   Zhao, L
   Liang, ZJ
   Yu, T
   Gao, J
AF Chen, Zi-yun
   Ye, Lu-wen
   Zhao, Li
   Liang, Zhao-jia
   Yu, Ting
   Gao, Jie
TI Hyperuricemia as a potential plausible risk factor for periodontitis
SO MEDICAL HYPOTHESES
LA English
DT Article
DE Gout; Hyperuricemia; Inflammation; Periodontal diseases; Risk factor;
   Uric acid; Xanthine coddase
ID URIC-ACID; XANTHINE-OXIDASE; SALIVARY; DISEASE; SERUM; ANTIOXIDANTS;
   PATHOGENESIS; ALLOPURINOL; METABOLISM; BIOMARKERS
AB Elevated blood uric acid (UA) levels have been positively associated with the severity of periodontitis. It thus brings out a hypothesis that hyperuricemia, a pathological elevation of blood UA, might be a risk factor for periodontitis. Namely, periodontitis individuals with Hu might acquire more severe periodontal destruction compared to those without Hu. To support the hypothesis, four aspects of evidences are proposed. First, hyperuricemia and periodontitis share many metabolic and inflammatory comorbidities such as metabolic syndrome, diabetes and cardiovascular diseases which are commonly related to elevated UA levels and gout. Second, observational and interventional studies have found altered UA levels in blood and saliva in periodontitis patients or after periodontal treatment, suggesting an epidemiological connection between hyperuricemia and periodontitis. Third, plausible immuno-metabolic mechanisms by which hyperuricemia might promote the progression of periodontitis are suggested, such as impaired immune response, oxidative stress, pathological bone remodeling and dysbiosis. The last, our empirical data exhibited elevated UA levels in gingival tissue in periodontitis mice compared to controls. If the hypothesis is true, given the high prevalence of the two conditions, hyperuricemia would be a significant risk factor increasing the global burden of periodontal diseases. Evidences on a directional correlation between hyperuricemia and periodontitis are sparse. Longitudinal and experimental studies would be necessary to determine the magnitude of periodontal risk, if any, exacerbated by hyperuricemia and the underlying mechanisms.
C1 [Chen, Zi-yun; Ye, Lu-wen; Liang, Zhao-jia; Yu, Ting; Gao, Jie] Guangzhou Med Univ, Stomatol Hosp, Guangzhou Inst Oral Dis, Dept Periodontol,Key Lab Oral Med, Guangzhou, Peoples R China.
   [Zhao, Li] Sun Yat Sen Univ, Guanghua Sch Stomatol, Dept Prosthodont, Guangzhou, Peoples R China.
   [Zhao, Li] Guangdong Prov Key Lab Stomatol, Guangzhou, Peoples R China.
C3 Guangzhou Medical University; Sun Yat Sen University
RP Gao, J (corresponding author), Guangzhou Med Univ, Stomatol Hosp, Guangzhou Inst Oral Dis, Dept Periodontol,Key Lab Oral Med, Guangzhou, Peoples R China.; Yu, T (corresponding author), Guangzhou Med Univ, Stomatol Hosp, 195 Dongfeng Rd West, Guangzhou 510140, Peoples R China.
EM dent_yu@163.com
RI Gao, Jie/AAH-5179-2021
OI Yu, Ting/0000-0002-8381-010X; Liang, Zhaojia/0000-0002-6401-0596
FU National Natural Science Foundation of China, Beijing, China [81700985];
   Guangzhou Medical University [C195015024]
FX Zi-yun Chen and Lu-wen Ye contribute equally to this paper. Ting Yu and
   Jie Gao are the co-corresponding authors. This paper was supported by
   the National Natural Science Foundation of China, Beijing, China, Grants
   81700985 and by Guangzhou Medical University, Grants C195015024. The
   funders had no role in the research hypothesis or preparation of the
   manuscript.
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   Zhao D, 2018, J PERIODONTAL RES, V53, P682, DOI 10.1111/jre.12565
   Zhou JL, 2018, CLIN CHIM ACTA, V478, P188, DOI 10.1016/j.cca.2017.12.046
NR 76
TC 19
Z9 19
U1 0
U2 24
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0306-9877
EI 1532-2777
J9 MED HYPOTHESES
JI Med. Hypotheses
PD APR
PY 2020
VL 137
AR 109591
DI 10.1016/j.mehy.2020.109591
PG 6
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA KW4CF
UT WOS:000521112300037
PM 32007821
DA 2025-06-11
ER

PT J
AU Stahl, EC
   Delgado, ER
   Alencastro, F
   LoPresti, ST
   Wilkinson, PD
   Roy, N
   Haschak, MJ
   Skillen, CD
   Monga, SP
   Duncan, AW
   Brown, BN
AF Stahl, Elizabeth C.
   Delgado, Evan R.
   Alencastro, Frances
   LoPresti, Samuel T.
   Wilkinson, Patrick D.
   Roy, Nairita
   Haschak, Martin J.
   Skillen, Clint D.
   Monga, Satdarshan P.
   Duncan, Andrew W.
   Brown, Bryan N.
TI Inflammation and Ectopic Fat Deposition in the Aging Murine Liver Is
   Influenced by CCR2
SO AMERICAN JOURNAL OF PATHOLOGY
LA English
DT Article
ID NONALCOHOLIC STEATOHEPATITIS; KUPFFER CELLS; OXIDATIVE STRESS; DISEASE;
   MACROPHAGES; RECRUITMENT; FIBROSIS; PROMOTES; TISSUE; HEPATOCYTES
AB Aging is associated with inflammation and metabolic syndrome, which manifests in the liver as nonalcoholic fatty liver disease (NAFLD). NAFLD can range in severity from steatosis to fibrotic steatohepatitis and is a major cause of hepatic morbidity. However, the pathogenesis of NAFLD in naturally aged animals is unclear. Herein, we performed a comprehensive study of lipid content and inflammatory signature of livers in 19-month-old aged female mice. These animals exhibited increased body and liver weight, hepatic triglycerides, and inflammatory gene expression compared with 3-month-old young controls. The aged mice also had a significant increase in F4/80(+) hepatic macrophages, which coexpressed CD11b, suggesting a circulating monocyte origin. A global knockout of the receptor for monocyte chemoattractant protein (CCR2) prevented excess steatosis and inflammation in aging livers but did not reduce the number of CD11b(+) macrophages, suggesting changes in macrophage accumulation precede or are independent from chemokine (C-C motif) ligand-CCR2 signaling in the development of age-related NAFLD. RNA sequencing further elucidated complex changes in inflammatory and metabolic gene expression in the aging liver. In conclusion, we report a previously unknown accumulation of CD11b(+) macrophages in aged livers with robust inflammatory and metabolic transcriptomic changes. A better understanding of the hallmarks of aging in the liver will be crucial in the development of preventive measures and treatments for end-stage liver disease in elderly patients.
C1 [Stahl, Elizabeth C.; Delgado, Evan R.; Alencastro, Frances; LoPresti, Samuel T.; Wilkinson, Patrick D.; Roy, Nairita; Haschak, Martin J.; Skillen, Clint D.; Monga, Satdarshan P.; Duncan, Andrew W.; Brown, Bryan N.] Univ Pittsburgh, McGowan Inst Regenerat Med, Pittsburgh, PA USA.
   [LoPresti, Samuel T.; Haschak, Martin J.; Brown, Bryan N.] Univ Pittsburgh, Swanson Sch Engn, Dept Bioengn, Pittsburgh, PA USA.
   [Monga, Satdarshan P.; Duncan, Andrew W.; Brown, Bryan N.] Univ Pittsburgh, Pittsburgh Liver Res Ctr, Pittsburgh, PA USA.
   [Stahl, Elizabeth C.; Delgado, Evan R.; Alencastro, Frances; Wilkinson, Patrick D.; Roy, Nairita; Monga, Satdarshan P.; Duncan, Andrew W.; Brown, Bryan N.] Univ Pittsburgh, Sch Med, Dept Pathol, Pittsburgh, PA USA.
   [Stahl, Elizabeth C.] Univ Calif Berkeley, Calif Inst Quantitat Biosci, Berkeley, CA 94720 USA.
   [LoPresti, Samuel T.] Carnegie Mellon Univ, Dept Chem Engn, Pittsburgh, PA 15213 USA.
   [Wilkinson, Patrick D.] Harvard Med Sch, Brigham & Womens Hosp, Div Genet, Boston, MA 02115 USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE); University
   of Pittsburgh; Pennsylvania Commonwealth System of Higher Education
   (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of
   Higher Education (PCSHE); University of Pittsburgh; Pennsylvania
   Commonwealth System of Higher Education (PCSHE); University of
   Pittsburgh; University of California System; University of California
   Berkeley; Carnegie Mellon University; Harvard University; Harvard
   Medical School; Harvard University Medical Affiliates; Brigham & Women's
   Hospital
RP Brown, BN (corresponding author), Univ Pittsburgh, Pittsburgh Liver Res Ctr, McGowan Inst Regenerat Med, Dept Bioengn, 450 Technol Dr,Ste 300, Pittsburgh, PA 15219 USA.; Duncan, AW (corresponding author), Univ Pittsburgh, Pittsburgh Liver Res Ctr, McGowan Inst Regenerat Med, Dept Pathol, 450 Technol Dr,Ste 300, Pittsburgh, PA 15219 USA.
EM duncana@pitt.edu; brownb@upmc.edu
RI Monga, Satdarshan/LLV-3357-2024
OI Monga, Satdarshan/0000-0002-8437-3378; LoPresti,
   Samuel/0000-0002-9941-7935; Wilkinson, Patrick/0000-0001-6643-8599;
   Delgado, Evan/0000-0003-2706-0946; Duncan, Andrew/0000-0003-4962-4191
FU NIH [R01-AG055564, R01-DK103645, F31-DK112633, U24-DK059637,
   P30-DK020593]; Cellular Approaches to Tissue Engineering and
   Regeneration T32 training grant [T32-EB001026]; Pittsburgh Liver
   Research Center Pilot and Feasibility Award [P30-DK120531]
FX Supported by NIH grants R01-AG055564 (B.N.B.), R01-DK103645 (A.W.D.),
   F31-DK112633 (E.C.S.), U24-DK059637, and P30-DK020593; the Cellular
   Approaches to Tissue Engineering and Regeneration T32 training grant
   T32-EB001026 (E.C.S., S.T.L., and M.J.H.); the Pittsburgh Liver Research
   Center Pilot and Feasibility Award P30-DK120531 (B.N.B.).
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NR 55
TC 27
Z9 30
U1 0
U2 4
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0002-9440
EI 1525-2191
J9 AM J PATHOL
JI Am. J. Pathol.
PD FEB
PY 2020
VL 190
IS 2
BP 372
EP 387
DI 10.1016/j.ajpath.2019.10.016
PG 16
WC Pathology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pathology
GA KF7SB
UT WOS:000509437800009
PM 31843499
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Boeckmans, J
   Natale, A
   Rombaut, M
   Buyl, K
   Rogiers, V
   De Kock, J
   Vanhaecke, T
   Rodrigues, RM
AF Boeckmans, Joost
   Natale, Alessandra
   Rombaut, Matthias
   Buyl, Karolien
   Rogiers, Vera
   De Kock, Joery
   Vanhaecke, Tamara
   Rodrigues, Robim M.
TI Anti-NASH Drug Development Hitches a Lift on PPAR Agonism
SO CELLS
LA English
DT Review
DE non-alcoholic steatohepatitis (NASH); non-alcoholic fatty liver disease
   (NAFLD); peroxisome proliferator-activated receptor (PPAR); elafibranor;
   lanifibranor; saroglitazar; pioglitazone
ID NONALCOHOLIC FATTY LIVER; ACTIVATED RECEPTOR-ALPHA;
   TUMOR-NECROSIS-FACTOR; ON-A-CHIP; DOUBLE-BLIND; INSULIN-RESISTANCE;
   HEPATIC STEATOSIS; NUCLEAR RECEPTORS; OXIDATIVE STRESS; REDUCES FEATURES
AB Non-alcoholic fatty liver disease (NAFLD) affects one-third of the population worldwide, of which a substantial number of patients suffer from non-alcoholic steatohepatitis (NASH). NASH is a severe condition characterized by steatosis and concomitant liver inflammation and fibrosis, for which no drug is yet available. NAFLD is also generally conceived as the hepatic manifestation of the metabolic syndrome. Consequently, well-established drugs that are indicated for the treatment of type 2 diabetes and hyperlipidemia are thought to exert effects that alleviate the pathological features of NASH. One class of these drugs targets peroxisome proliferator-activated receptors (PPARs), which are nuclear receptors that play a regulatory role in lipid metabolism and inflammation. Therefore, PPARs are now also being investigated as potential anti-NASH druggable targets. In this paper, we review the mechanisms of action and physiological functions of PPARs and discuss the position of the different PPAR agonists in the therapeutic landscape of NASH. We particularly focus on the PPAR agonists currently under evaluation in clinical phase II and III trials. Preclinical strategies and how refinement and optimization may improve PPAR-targeted anti-NASH drug testing are also discussed. Finally, potential caveats related to PPAR agonism in anti-NASH therapy are stipulated.
C1 [Boeckmans, Joost; Natale, Alessandra; Rombaut, Matthias; Buyl, Karolien; Rogiers, Vera; De Kock, Joery; Vanhaecke, Tamara; Rodrigues, Robim M.] Vrije Univ Brussel, Dept Vitro Toxicol & Dermatocosmetol IVTD, Fac Med & Pharm, Laarbeeklaan 103, B-1090 Brussels, Belgium.
C3 Vrije Universiteit Brussel
RP Rodrigues, RM (corresponding author), Vrije Univ Brussel, Dept Vitro Toxicol & Dermatocosmetol IVTD, Fac Med & Pharm, Laarbeeklaan 103, B-1090 Brussels, Belgium.
EM Joost.Boeckmans@vub.be; Alessandra.Natale@vub.be;
   Matthias.Rombaut@vub.be; Karolien.Buyl@vub.be; Vera.Rogiers@vub.be;
   Joery.De.Kock@vub.be; Tamara.Vanhaecke@vub.be;
   Robim.Marcelino.Rodrigues@vub.be
RI ; De Kock, Joery/M-5832-2014; Rodrigues, Robim/K-1366-2015
OI Vanhaecke, Tamara/0000-0002-6685-7299; De Kock,
   Joery/0000-0002-4078-4896; Natale, Alessandra/0000-0003-2403-8540;
   Rodrigues, Robim/0000-0003-2927-6791; Rombaut,
   Matthias/0000-0002-1101-1739; Buyl, Karolien/0000-0002-4889-9284;
   Boeckmans, Joost/0000-0001-8399-5872; Rogiers, Vera/0000-0003-0635-7740
FU Research Foundation Flanders [1S10518N, 12H2216N, 1S73019N, G042019N];
   University Hospital of the Vrije Universiteit Brussel-Belgium (Willy
   Gepts Fonds UZ-VUB); Research Chair Mireille Aerens for Alternatives to
   Animal Testing; Onderzoeksraad Vrije Universiteit Brussel
FX This work was funded by grants of Research Foundation Flanders
   (1S10518N, 12H2216N, 1S73019N and G042019N), University Hospital of the
   Vrije Universiteit Brussel-Belgium (Willy Gepts Fonds UZ-VUB),
   Onderzoeksraad Vrije Universiteit Brussel and the Research Chair
   Mireille Aerens for Alternatives to Animal Testing.
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NR 139
TC 99
Z9 104
U1 7
U2 49
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2073-4409
J9 CELLS-BASEL
JI Cells
PD JAN
PY 2020
VL 9
IS 1
AR 37
DI 10.3390/cells9010037
PG 20
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA KO2RZ
UT WOS:000515398200037
PM 31877771
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Carranza-Lira, S
   Montiel, MM
   Camacho, KO
   Santana, XH
   Ortiz, SR
   Muñoz, EL
   Angeles, LCEH
AF Carranza-Lira, Sebastian
   Montes Montiel, Maryel
   Ocampo Camacho, Karina
   Hernandez Santana, Xiomara
   Rosales Ortiz, Sergio
   Lopez Munoz, Eunice
   Erick Hernandez Angeles, Luis Claudio
TI Relationship of the neutrophil/lymphocyte ratio with cardiovascular risk
   markers in premenopausal and postmenopausal women
SO MENOPAUSE REVIEW-PRZEGLAD MENOPAUZALNY
LA English
DT Article
DE neutrophil/lymphocyte ratio; platelet/lymphocyte ratio; inflammation;
   premenopause; post-menopause
ID NEUTROPHIL-LYMPHOCYTE RATIO; FLOW-MEDIATED VASODILATION; EPICARDIAL
   ADIPOSE-TISSUE; VASCULAR OXIDATIVE STRESS; CAROTID INTIMA-MEDIA;
   VISCERAL FAT; METABOLIC SYNDROME; MENOPAUSAL WOMEN; HORMONE-THERAPY;
   NITRIC-OXIDE
AB Introduction: Cardiovascular disease is more frequent in postmenopausal women. Atherosclerosis is associated with inflammation and the neutrophil/lymphocyte ratio (NLR) is a marker of inflammation whose behavior in postmenopause is unknown.
   Aim of the study: To know the relationship of the NLR with cardiovascular risk markers in premenopausal and postmenopausal women.
   Material and methods: Premenopausal and postmenopausal women were studied, in all of them a complete hemogram and the NLR, platelet/lymphocyte ratio (PLR) were calculated, also glucose and lipids levels were measured. In all of them subcutaneous and visceral fat, carotid intima-media thickness (IMT), epicardial fat were measured by ultrasound Also baseline and and after flow-mediated stimulus the arterial diameter, the pulsatility index and the resistive index of the brachial artery were measured by ultrasound. The results are reported with medians and intervals, Mann-Whitney U and Spearman correlation analysis were performed.
   Results: Eighty two patients were recruited, 41 premenopausal and 41 postmenopausal. When comparing both groups there was no difference in glucose, lipids, NLR, PLR, carotid IMT, epicardial fat, subcutaneous fat, visceral fat or Doppler parameters of the brachial artery.
   Conclusion: NLR was not different between premenopausal and postmenopausal women but abnormal PLR was greater in those postmenopausal with vasomotor symptoms.
C1 [Carranza-Lira, Sebastian; Montes Montiel, Maryel; Ocampo Camacho, Karina; Hernandez Santana, Xiomara; Rosales Ortiz, Sergio; Lopez Munoz, Eunice; Erick Hernandez Angeles, Luis Claudio] UMAE Gynaecol & Obstet Hosp Luis Castelazo Ayala, Mexican Inst, Social Secur, Mexico City, DF, Mexico.
RP Carranza-Lira, S (corresponding author), Puente Piedra 150-422,Torre 1, Mexico City 14050, DF, Mexico.
EM drsebastiancarranza@gmail.com
RI Lopez-Munoz, Eunice/K-4106-2013
OI Lopez-Munoz, Eunice/0000-0002-6552-170X
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NR 49
TC 2
Z9 2
U1 0
U2 4
PU TERMEDIA PUBLISHING HOUSE LTD
PI POZNAN
PA KLEEBERGA 2, POZNAN, 61-615, POLAND
SN 1643-8876
EI 2299-0038
J9 MENOPAUSE REV
JI Prz. Menopauzalny
PY 2020
VL 19
IS 2
BP 53
EP 60
DI 10.5114/pm.2020.97835
PG 8
WC Obstetrics & Gynecology
WE Emerging Sources Citation Index (ESCI)
SC Obstetrics & Gynecology
GA QD5ZN
UT WOS:000615596000001
PM 32802014
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Guo, J
   Li, C
   Yang, CX
   Li, B
   Wei, J
   Lin, YJ
   Ye, P
   Hu, G
   Li, J
AF Guo, Jun
   Li, Cai
   Yang, Chunxiao
   Li, Bing
   Wei, Jie
   Lin, Yajun
   Ye, Peng
   Hu, Gang
   Li, Jian
TI Liraglutide reduces hepatic glucolipotoxicity-induced liver cell
   apoptosis through NRF2 signaling in Zucker diabetic fatty rats
SO MOLECULAR MEDICINE REPORTS
LA English
DT Article
DE liraglutide; glucolipotoxicity; liver cell apoptosis; nuclear
   factor-erythroid 2-related factor 2 signaling
ID ANTIOXIDANT RESPONSIVE ELEMENT; VASCULAR ENDOTHELIAL-CELLS; PEPTIDE-1
   GLP-1 PROTECTS; OXIDATIVE STRESS; METABOLIC SYNDROME; ANALOG
   LIRAGLUTIDE; INSULIN-RESISTANCE; RECEPTOR AGONISTS; DISEASE; PREVALENCE
AB The primary aim of the present study was to evaluate the effects of liraglutide on glucolipotoxicity-induced liver cell apoptosis and the underlying mechanisms in Zucker diabetic fatty (ZDF) rats. The results revealed that liraglutide significantly decreased the body weight, hyperglycemia and hyperlipidemia of ZDF rats relative to those of Zucker lean (ZL) rats (P<0.05). Furthermore, the reduced liver cell apoptosis was observed in the ZDF rats following 6 weeks of liraglutide therapy. These data validated the beneficial effects of liraglutide on diabetic and obese ZDF rats. In addition, novel data was obtained that demonstrated that liraglutide treatment increased the expression of the antioxidant transcription factor nuclear factor-erythroid 2-related factor 2 (NRF2), as well as the transcription of downstream target genes, including nicotinamide adenine dinucleotide phosphate quinone dehydrogenase 1 and heme oxygenase-1 (P<0.05). Additionally, serum and hepatic GSH and SOD levels increased following liraglutide therapy (P<0.05). Hence, it was proposed that liraglutide may enhance the antioxidant activity of liver cells by activating the NRF2 signaling pathway, thereby reducing liver cell apoptosis induced by glucolipotoxicity in ZDF rats, which may shed light on the application of liraglutide in the treatment of diabetes- and obesity-induced liver injury.
C1 [Guo, Jun; Li, Cai; Yang, Chunxiao; Wei, Jie; Lin, Yajun; Ye, Peng; Hu, Gang; Li, Jian] Beijing Hosp, Natl Ctr Gerontol, MOH Key Lab Geriatr, 1 Dahua Rd, Beijing 100730, Peoples R China.
   [Li, Cai] Qingdao Univ, Dept Internal Med, Affiliated Hosp, Qingdao 266071, Shandong, Peoples R China.
   [Yang, Chunxiao] Peking Univ, Beijing Hosp, Sch Clin Med 5, Beijing 100730, Peoples R China.
   [Li, Bing] Shandong Univ Tradit Chinese Med, Dept Encephalopathy, Med Dept Chinese Med, Jinan 250355, Shandong, Peoples R China.
C3 Beijing Hospital; Qingdao University; Beijing Hospital; Peking
   University; Shandong University of Traditional Chinese Medicine
RP Hu, G; Li, J (corresponding author), Beijing Hosp, Natl Ctr Gerontol, MOH Key Lab Geriatr, 1 Dahua Rd, Beijing 100730, Peoples R China.
EM hu61@hotmail.com; lijian@bjhmoh.cn
RI Wei, Jie/ACR-8087-2022; Lin, Yajun/KJM-4967-2024
FU National Natural Science Foundation of China [81570789, 81700765]
FX The present study was supported by grants (grant nos. 81570789 and
   81700765) from National Natural Science Foundation of China.
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NR 50
TC 21
Z9 21
U1 0
U2 12
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1791-2997
EI 1791-3004
J9 MOL MED REP
JI Mol. Med. Rep.
PD JUN
PY 2018
VL 17
IS 6
BP 8316
EP 8324
DI 10.3892/mmr.2018.8919
PG 9
WC Oncology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Research & Experimental Medicine
GA GJ5AQ
UT WOS:000435394000105
PM 29693190
OA hybrid, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Shin, NR
   Bose, S
   Wang, JH
   Ansari, A
   Lim, SK
   Chin, YW
   Choi, HS
   Kim, H
AF Shin, Na R.
   Bose, Shambhunath
   Wang, Jing-Hua
   Ansari, AbuZar
   Lim, Soo-Kyoung
   Chin, Young-won
   Choi, Han-seok
   Kim, Hojun
TI Flos Lonicera Combined with Metformin Ameliorates Hepatosteatosis
   and Glucose Intolerance in Association with Gut Microbiota Modulation
SO FRONTIERS IN MICROBIOLOGY
LA English
DT Article
DE Flos Lonicera; metformin; metabolic syndrome; gut microbiota;
   hepatosteatosis
ID ACTIVATED PROTEIN-KINASE; FATTY LIVER-DISEASE; NONALCOHOLIC
   STEATOHEPATITIS; COMBINATION THERAPY; OXIDATIVE STRESS; JAPONICA THUNB.;
   ETHANOL EXTRACT; OBESITY; CHOLESTEROL; DIET
AB The gut microbiota is important in energy contribution, metabolism and immune modulation, and compositional disruption of the gut microbiota population is closely associated with chronic metabolic diseases like type 2 diabetes (T2D) and non-alcoholic fatty liver disease (NAFLD). Metformin (MET) and Flos Lonicera (FL) are common treatments for metabolic diseases inWestern and Oriental medicinal fields. We evaluated the effect of treatment with FL and MET in combination on hepatosteatosis, glucose tolerance, and gut microbial composition. FL and MET were administered to Otsuka Long-Evans Tokushima Fatty (OLETF) rats, an animal model of genetic T2D and NAFLD. The FL+MET treatment reduced liver weight, serum cholesterol, insulin resistance, and hepatic MDA level and modulated the gut microbial composition. More specifically, the genera of Prevotella and Lactobacillus were negatively associated with the body and liver weights, hepatic TG and TC content, and serum insulin level. However, the relative abundance of these genera decreased in response to the FL+ MET treatment. Interestingly, pathway prediction data revealed that the FL+ MET treatment attenuated lipopolysaccharide-related pathways, in keeping with the decrease in serum and fecal endotoxin levels. FL and MET in combination exerts a synergistic effect on the improvement of hepatosteatosis and insulin sensitivity in OLETF rats, and modulates gut microbiota in association with the effect.
C1 [Shin, Na R.; Wang, Jing-Hua; Ansari, AbuZar; Lim, Soo-Kyoung; Kim, Hojun] Dongguk Univ, Dept Rehabil Med Korean Med, Goyang, South Korea.
   [Bose, Shambhunath] NosQuest, Seongnam Si, Gyeonggi Do, South Korea.
   [Chin, Young-won] Dongguk Univ, Coll Pharm, Goyang, South Korea.
   [Choi, Han-seok] Dongguk Univ, Dept Endocrinol, Goyang, South Korea.
C3 Dongguk University; Dongguk University; Dongguk University
RP Kim, H (corresponding author), Dongguk Univ, Dept Rehabil Med Korean Med, Goyang, South Korea.
EM kimklar@gmail.com
RI ANSARI, ABUZAR/AAZ-2578-2020; Wang, Jing-hua/AAO-2350-2020; Choi,
   Han/AAG-1493-2019; Kim, Hojun/AAB-8405-2020; Bose,
   Shambhunath/HKW-2568-2023
OI Chin, Young-Won/0000-0001-6964-1779; Wang, jing-hua/0000-0002-2034-7429;
   Bose, Shambunath/0000-0003-0737-5713
FU Convergence of Conventional Medicine and Traditional Korean Medicine R&D
   program - Ministry of Health and Welfare through the Korea Health
   Industry Development Institute [HI14C0558]
FX This work was supported by the grant of Convergence of Conventional
   Medicine and Traditional Korean Medicine R&D program funded by the
   Ministry of Health and Welfare through the Korea Health Industry
   Development Institute (HI14C0558).
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NR 63
TC 37
Z9 39
U1 1
U2 21
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-302X
J9 FRONT MICROBIOL
JI Front. Microbiol.
PD NOV 17
PY 2017
VL 8
AR 2271
DI 10.3389/fmicb.2017.02271
PG 16
WC Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Microbiology
GA FM9LB
UT WOS:000415589600001
PM 29204141
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Pagano, ES
   Spinedi, E
   Gagliardino, JJ
AF Pagano, Eleonora S.
   Spinedi, Eduardo
   Gagliardino, Juan J.
TI White Adipose Tissue and Circadian Rhythm Dysfunctions in Obesity:
   Pathogenesis and Available Therapies
SO NEUROENDOCRINOLOGY
LA English
DT Article
DE Adipose tissue mass expansion; Chronobiology; Obesity
   prevention/treatment; Clock genes; Adipose tissue dysfunction; Obesity
   pathogenesis; Glucose regulation; Central/peripheral clocks; Nutrients;
   Feeding time; Chronotherapeutic approach
ID HIGH-FAT DIET; CLOCK GENE-EXPRESSION; BARIATRIC SURGERY;
   AMERICAN-COLLEGE; METABOLIC SYNDROME; NIGHT-WORK; BETA-CELL;
   NONALCOHOLIC STEATOHEPATITIS; CLINICAL ENDOCRINOLOGISTS; RECEPTOR
   EXPRESSION
AB A combined neuroendocrine, metabolic, and chronobiological view can help to better understand the multiple and complex mechanisms involved in obesity development and maintenance, as well as to provide new effective approaches for its control and treatment. Indeed, we have currently updated data on the whole adipogenic process involved in white adipose tissue (WAT) mass expansion, namely due to a mechanism whereby WAT cells become hypertrophic, thus inducing a serious local (WAT) inflammatory condition that in turn, will impair not only the cross-talk between the hypothalamus and the WAT, but also favoring the development of deep and widespread neuroendocrine-metabolic dysfunction. Moreover, we also have revisited the circadian clock genes involved in dysfunctional WAT mass expansion and the mechanisms that may lead to obesity development, including early metabolic dysfunctions, enhanced oxidative stress and distorted energy homeostasis. The epigenetic changes of clock genes driving metabolic disease and obesity development have also been included in this review. Finally, we have also underlined the relevance of metabolic homeostasis regulation by central and peripheral organ clocks, sleep disturbances, nutrients, and feeding time, as key factors in obesity development as well as both, classical and chronotherapeutic approaches for its prevention and treatment. (C) 2016 S. Karger AG, Basel
C1 [Pagano, Eleonora S.] Pontifical Catholic Univ, Inst Biomed Res BIOMED UCA CONICET, Fac Med Sci, Buenos Aires, DF, Argentina.
   [Spinedi, Eduardo; Gagliardino, Juan J.] La Plata Natl Univ, La Plata Med Sch, Ctr Expt & Appl Endocrinol UNLP CONICET FCM, La Plata, Buenos Aires, Argentina.
C3 Pontificia Universidad Catolica Argentina; National University of La
   Plata
RP Spinedi, E (corresponding author), La Plata Natl Univ, La Plata Med Sch, CENEXA UNLP CONICET FCM, RA-1900 La Plata, Buenos Aires, Argentina.
EM spinedi@cenexa.org
FU Fondation pour la Recherche en Endocrinologie, Diabetologie et
   Metabolisme (FPREDM) [052015]
FX Authors wish to thank Mrs. Susan H. Rogers and Ms. Rebecca Doyle for
   their careful English (grammar and style) correction of the manuscript.
   This research was supported by a grant from Fondation pour la Recherche
   en Endocrinologie, Diabetologie et Metabolisme (FPREDM 052015 to E.S.).
   E.S.P., E.S. and J.J.G. are members of the Research Career from CONICET
   (Argentina).
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NR 154
TC 22
Z9 23
U1 0
U2 14
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0028-3835
EI 1423-0194
J9 NEUROENDOCRINOLOGY
JI Neuroendocrinology
PY 2017
VL 104
IS 4
BP 347
EP 363
DI 10.1159/000453317
PG 17
WC Endocrinology & Metabolism; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology
GA EQ8QU
UT WOS:000398351400004
PM 27846625
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Cox, AJ
   Lehtinen, AB
   Xu, JZ
   Langefeld, CD
   Freedman, BI
   Carr, JJ
   Bowden, DW
AF Cox, Amanda. J.
   Lehtinen, Allison B.
   Xu, Jianzhao
   Langefeld, Carl D.
   Freedman, Barry I.
   Carr, J. Jeffrey
   Bowden, Donald W.
TI Polymorphisms in the Selenoprotein S gene and subclinical cardiovascular
   disease in the Diabetes Heart Study
SO ACTA DIABETOLOGICA
LA English
DT Article
DE Genetics; Atherosclerosis; Calcified plaque; Diabetes mellitus
ID ENDOPLASMIC-RETICULUM STRESS; CORONARY-ARTERY CALCIUM; INFLAMMATORY
   RESPONSE; METABOLIC SYNDROME; ATHEROSCLEROSIS; ASSOCIATION; EXPRESSION;
   LINKAGE; PLAQUE; CT
AB Selenoprotein S (SelS) has previously been associated with a range of inflammatory markers, particularly in the context of cardiovascular disease (CVD). The aim of this study was to examine the role of SELS genetic variants in risk for subclinical CVD and mortality in individuals with type 2 diabetes mellitus (T2DM). The association between 10 polymorphisms tagging SELS and coronary (CAC), carotid (CarCP) and abdominal aortic calcified plaque, carotid intima media thickness and other known CVD risk factors was examined in 1220 European Americans from the family-based Diabetes Heart Study. The strongest evidence of association for SELS SNPs was observed for CarCP; rs28665122 (5' region; beta = 0.329, p = 0.044), rs4965814 (intron 5; beta = 0.329, p = 0.036), rs28628459 (3' region; beta = 0.331, p = 0.039) and rs7178239 (downstream; beta = 0.375, p = 0.016) were all associated. In addition, rs12917258 (intron 5) was associated with CAC (beta = -0.230, p = 0.032), and rs4965814, rs28628459 and rs9806366 were all associated with self-reported history of prior CVD (p = 0.020-0.043). These results suggest a potential role for the SELS region in the development subclinical CVD in this sample enriched for T2DM. Further understanding the mechanisms underpinning these relationships may prove important in predicting and managing CVD complications in T2DM.
C1 [Cox, Amanda. J.; Lehtinen, Allison B.; Xu, Jianzhao; Bowden, Donald W.] Wake Forest Sch Med, Ctr Human Genom, Winston Salem, NC 27157 USA.
   [Cox, Amanda. J.; Lehtinen, Allison B.; Xu, Jianzhao; Bowden, Donald W.] Wake Forest Sch Med, Ctr Diabet Res, Winston Salem, NC 27157 USA.
   [Cox, Amanda. J.; Lehtinen, Allison B.; Bowden, Donald W.] Wake Forest Sch Med, Dept Biochem, Winston Salem, NC 27157 USA.
   [Langefeld, Carl D.] Wake Forest Sch Med, Dept Biostat Sci, Winston Salem, NC 27157 USA.
   [Freedman, Barry I.] Wake Forest Sch Med, Dept Internal Med Nephrol, Winston Salem, NC 27157 USA.
   [Carr, J. Jeffrey] Wake Forest Sch Med, Dept Radiol Sci, Winston Salem, NC 27157 USA.
C3 Wake Forest University; Wake Forest University; Wake Forest University;
   Wake Forest University; Wake Forest University; Wake Forest University
RP Bowden, DW (corresponding author), Wake Forest Sch Med, Dept Biochem, Med Ctr Blvd, Winston Salem, NC 27157 USA.
EM dbowden@wakehealth.edu
RI Carr, John/A-1938-2012
OI Carr, John/0000-0002-4398-8237
FU  [R01 HL67348];  [R01 HL09230];  [R01 NS058700]
FX This study was supported in part by R01 HL67348, R01 HL09230, and R01
   NS058700 to Dr Donald W Bowden. The authors thank the other
   investigators, the staff, and the participants of the DHS study for
   their valuable contributions. We would like to acknowledge the Centre
   for Public Health Genomics at Wake Forest University for its continued
   support of our biostatisticians.
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NR 33
TC 48
Z9 51
U1 0
U2 13
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0940-5429
J9 ACTA DIABETOL
JI Acta Diabetol.
PD JUN
PY 2013
VL 50
IS 3
BP 391
EP 399
DI 10.1007/s00592-012-0440-z
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 159SP
UT WOS:000320066500013
PM 23161441
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Yin, Y
   Pastrana, JL
   Li, XY
   Huang, X
   Mallilankaraman, K
   Choi, ET
   Madesh, M
   Wang, H
   Yang, XF
AF Yin, Ying
   Pastrana, Jahaira Lopez
   Li, Xinyuan
   Huang, Xiao
   Mallilankaraman, Karthik
   Choi, Eric T.
   Madesh, Muniswamy
   Wang, Hong
   Yang, Xiao-Feng
TI Inflammasomes: sensors of metabolic stresses for vascular inflammation
SO FRONTIERS IN BIOSCIENCE-LANDMARK
LA English
DT Article
DE inflammasomes; Caspase-1; ROS; Vascular Inflammation; Interleukin-1
   beta; Atherosclerosis; Review
ID SMOOTH-MUSCLE-CELLS; NALP3 INFLAMMASOME; NLRP3 INFLAMMASOME; ACTIVATED
   MACROPHAGES; INTERLEUKIN-1-BETA; ATHEROSCLEROSIS; DEATH; DEFICIENT;
   CASPASE-1; PROTEIN
AB Metabolic syndrome is a major health issue in the western world. An elevated pro-inflammatory state is often found in patients with metabolic diseases such as type 2 diabetes and obesity. Atherosclerosis is one such clinical manifestation of pro-inflammatory state associated with the vasculature. The exact mechanism by which metabolic stress induces this pro-inflammatory status and promotes atherogenesis remained elusive until the discovery of the inflammasome protein complex. This complex is composed of pro-caspase-1 and pathogen sensors. Activation of inflammasome requires the transcriptional upregulation of inflammasome components and the post-translational assembly. Three models of inflammasome assembly have been proposed: 1) the ion channel model; 2) the reactive oxygen species (ROS) model; and 3) the lysosome model. In either case, inflammasome activation triggers the auto-activation of pro-caspase-1 into its mature form. Caspase-1, which was first discovered as the IL-1 beta converting enzyme, is known to be a major player in inflammatory and cell death pathways. Many endogenous metabolic ligands have been experimentally shown to activate inflammasome, and thus initiate the subsequent inflammation process. Further understanding of the distinct molecular mechanism by which metabolic ligands activates inflammasome could lead to developing novel therapeutic interventions for atherosclerosis and other clinical problems related to metabolic diseases.
C1 [Yin, Ying; Pastrana, Jahaira Lopez; Li, Xinyuan; Huang, Xiao; Wang, Hong; Yang, Xiao-Feng] Temple Univ, Sch Med, Dept Pharmacol, Cardiovasc Res Ctr, Philadelphia, PA 19140 USA.
   [Choi, Eric T.] Temple Univ, Sch Med, Dept Surg, Philadelphia, PA 19140 USA.
   [Mallilankaraman, Karthik; Madesh, Muniswamy] Temple Univ, Sch Med, Dept Biochem, Philadelphia, PA 19140 USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE); Temple
   University; Pennsylvania Commonwealth System of Higher Education
   (PCSHE); Temple University; Pennsylvania Commonwealth System of Higher
   Education (PCSHE); Temple University
RP Yang, XF (corresponding author), Temple Univ, Sch Med, Dept Pharmacol, 3500 North Broad St,MERB 1059, Philadelphia, PA 19140 USA.
EM xfyang@temple.edu
RI HUANG, XIAO/ABB-9211-2020; MALLILANKARAMAN, KARTHIK/LJL-1439-2024; Li,
   Xinyuan/Z-6299-2019; Yin, Ying/AAE-6450-2020; Li, Xinyuan/B-1139-2015
OI , xiao/0000-0003-0686-6318; MALLILANKARAMAN,
   KARTHIK/0000-0002-9492-9050; Li, Xinyuan/0000-0002-6746-8367; Yin,
   Ying/0000-0003-2156-4588
FU National Institutes of Health [HL094451, HL108910, HL67033, HL110764,
   HL77288]
FX This work was partially supported by the National Institutes of Health
   Grants HL094451 and HL108910 (XFY), HL67033, HL110764 and HL77288 (HW).
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TC 115
Z9 125
U1 0
U2 24
PU FRONTIERS IN BIOSCIENCE INC
PI IRVINE
PA 16471 SCIENTIFIC WAY, IRVINE, CA 92618 USA
SN 1093-9946
EI 1093-4715
J9 FRONT BIOSCI-LANDMRK
JI Front. Biosci.
PD JAN 1
PY 2013
VL 18
BP 638
EP 649
DI 10.2741/4127
PG 12
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA 173RR
UT WOS:000321097100018
PM 23276949
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Peiris, AN
   Youssef, D
   Grant, WB
AF Peiris, Alan N.
   Youssef, Dima
   Grant, William B.
TI Secondary Hyperparathyroidism: Benign Bystander or Culpable Contributor
   to Adverse Health Outcomes?
SO SOUTHERN MEDICAL JOURNAL
LA English
DT Review
DE cardiovascular disease; mortality; parathyroid hormone; renal disease;
   secondary hyperparathyroidism; 25(OH) vitamin D
ID PARATHYROID-HORMONE LEVELS; ALL-CAUSE MORTALITY; SERUM 25-HYDROXYVITAMIN
   D; PERITONEAL-DIALYSIS PATIENTS; VITAMIN-D STATUS; BLOOD-PRESSURE;
   CARDIOVASCULAR-DISEASE; VASCULAR CALCIFICATION; RENAL-FUNCTION; BONE
   TURNOVER
AB Elevation in serum parathyroid hormone (PTH) often accompanies vitamin D deficiency and renal impairment. PTH elevation in renal failure is viewed as an unfavorable development. Evidence is increasing that PTH elevation may be associated with increased morbidity and mortality. In many instances these PTH effects appear to be independent of vitamin D status. PTH mediates its effects through the ubiquitous type 1 PTH/PTHY-related peptide receptor, which is notably present in the cardiovascular system. Increased PTH may promote cardiovascular disease through diminished cardiac contractility, enhanced coronary risk, and cardiac valvular and vascular calcification. High PTH levels appear to be linked to the metabolic syndrome and are aligned with hyperlipidemia, decreased insulin sensitivity, and, perhaps, decreased insulin secretion. Increased PTH also is associated with neuroendocrine activation, increased sympathetic activity, and endothelial stress. The relation between PTH and vitamin D is complex and may show significant threshold variations, especially when calcium intake, age, and race are considered. Moreover, evidence is increasing that fragments of PTH may not only be hormonally active but also may have opposing effects to PTH. Despite these caveats, PTH values provide useful clinical diagnostic and prognostic information in monitoring many chronic ailments such as heart and renal failure and multiple sclerosis.
C1 [Peiris, Alan N.] E Tennessee State Univ, Dept Internal Med, Johnson City, TN 37614 USA.
   Sunlight Nutr & Hlth Res Ctr, San Francisco, CA USA.
C3 East Tennessee State University
RP Peiris, AN (corresponding author), E Tennessee State Univ, Dept Internal Med, POB 70622, Johnson City, TN 37614 USA.
EM Peiris@etsu.edu
RI ; Grant, William/B-8311-2009
OI Peiris, Alan/0000-0001-9323-7557; Grant, William/0000-0002-1439-3285
FU UV Foundation; Vitamin D Society; Bio-Tech Pharmacal; Vitamin D
   Association; Joerg Spitz, MD (speaking engagement)
FX W.B.G. is an employee of the Vitamin D Council and has received
   compensation or research support from the UV Foundation, the Vitamin D
   Society, Bio-Tech Pharmacal, the Vitamin D Association, and Joerg Spitz,
   MD (speaking engagement). The other authors have no financial
   relationships to disclose and no conflicts of interest to report.
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NR 94
TC 23
Z9 25
U1 0
U2 8
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0038-4348
EI 1541-8243
J9 SOUTH MED J
JI South.Med.J.
PD JAN
PY 2012
VL 105
IS 1
BP 36
EP 42
DI 10.1097/SMJ.0b013e31823c4155
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 869PC
UT WOS:000298609200008
PM 22189665
DA 2025-06-11
ER

PT J
AU Liu, HY
   Yehuda-Shnaidman, E
   Hong, T
   Han, JM
   Pi, JB
   Liu, ZQ
   Cao, WH
AF Liu, Hui-Yu
   Yehuda-Shnaidman, Einav
   Hong, Tao
   Han, Jianmin
   Pi, Jingbo
   Liu, Zhenqi
   Cao, Wenhong
TI Prolonged Exposure to Insulin Suppresses Mitochondrial Production in
   Primary Hepatocytes
SO JOURNAL OF BIOLOGICAL CHEMISTRY
LA English
DT Article
ID ACTIVATED PROTEIN-KINASE; HUMAN SKELETAL-MUSCLE; GENE-EXPRESSION;
   ADIPOSE-TISSUE; HEPATIC GLUCONEOGENESIS; PYRUVATE-DEHYDROGENASE;
   METABOLIC SYNDROME; SIGNALING PATHWAY; OXIDATIVE STRESS; AMINO-ACIDS
AB Insulin is the central regulator of metabolism and is necessary for storing energy as fat efficiently. Mitochondria are primary sites of energy consumption of most cells. Increased plasma insulin level and mitochondrial dysfunction are features of insulin resistance. The exact role of insulin in regulation of mitochondrial production and function remains unestablished. In this study, we observed that mitochondrial production in liver and skeletal muscle gastrocnemius was increased in mice with insulin deficiency (streptozotocin-induced type 1 diabetes). In contrast, prolonged exposure (24 h) of isolated hepatocytes to insulin decreased mitochondrial mass, mitochondrial DNA (mtDNA), intracellular ATP content, and cellular O-2 consumption. Transcript levels of genes associated with mitochondrial production and beta oxidation were decreased, whereas those of lipogenic genes were increased by the prolonged exposure to insulin. Insulin-induced changes in mtDNA, mitochondrial mass, intracellular ATP content, and transcripts of mitochondrion-associated genes were prevented by blockade of Akt activation with the phosphatidylinositol 3-kinase inhibitor LY294002. Conversely, levels of mtDNA, intracellular ATP content, and expression of mitochondrion-associated genes were decreased by overexpression of the constitutively active Akt. Finally, insulin suppression of mtDNA, ATP production, and expression of mitochondrion-related genes was largely prevented by inhibition of cyclic nucleotide phosphodiesterase with isobutylmethylxanthine. Together, our results show prolonged exposure of isolated hepatocytes to insulin suppresses mitochondrial production and function through the classical Akt-dependent insulin signaling pathway.
C1 [Cao, Wenhong] Duke Univ, Med Ctr, Dept Internal Med Endocrinol, Durham, NC 27705 USA.
   [Liu, Hui-Yu; Yehuda-Shnaidman, Einav; Hong, Tao; Han, Jianmin; Pi, Jingbo; Cao, Wenhong] Hamner Inst Hlth Sci, Res Triangle Pk, NC 27709 USA.
   [Liu, Zhenqi] Univ Virginia, Med Sci Ctr, Dept Med Endocrinol, Charlottesville, VA 22908 USA.
C3 Duke University; The Hamner Institutes for Health Sciences; University
   of Virginia
RP Cao, WH (corresponding author), Duke Univ, Med Ctr, Dept Internal Med Endocrinol, Durham, NC 27705 USA.
EM wcao@thehamner.org
RI Liu, Hui-Yu/D-1507-2009; PI, JINGBO/GWC-2514-2022
OI pi, Jingbo/0000-0003-0227-8041
FU National Institutes of Health [R01DK076039]; Investigator Development
   Fund from the Hamner Institutes for Health Sciences; American Heart
   Association [SDG-0530244N]
FX This work was supported, in whole or in part, by National Institutes of
   Health Grant R01DK076039 (to W. C.). This work was also supported by the
   Investigator Development Fund from the Hamner Institutes for Health
   Sciences (to W. C.) and American Heart Association Grant SDG-0530244N
   (to W. C.).
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NR 56
TC 48
Z9 56
U1 0
U2 5
PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3996 USA
EI 1083-351X
J9 J BIOL CHEM
JI J. Biol. Chem.
PD MAY 22
PY 2009
VL 284
IS 21
BP 14087
EP 14095
DI 10.1074/jbc.M807992200
PG 9
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 448TY
UT WOS:000266286100015
PM 19336408
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Wang, GQ
   Mao, WA
   Zhang, YR
   Yang, HY
   Zhu, M
   Li, Y
   Chen, W
   Chen, Y
   Lou, C
   Li, P
   Chang, HM
   Yuan, S
   Zhao, Y
   Mu, LS
AF Wang, Guiquan
   Mao, Weian
   Zhang, Yurong
   Yang, Haiyan
   Zhu, Ming
   Li, Yan
   Chen, Wei
   Chen, Yi
   Lou, Chen
   Li, Ping
   Chang, Hsun-Ming
   Yuan, Shuai
   Zhao, Yue
   Mu, Liangshan
TI Multiomics and Systematic Analyses Reveal the Roles of Hemoglobin and
   the HIF-1 Pathway in Polycystic Ovary Syndrome
SO ADVANCED SCIENCE
LA English
DT Article
DE causality; hemoglobin; hyperandrogenism; hypoxia-inducible factor;
   polycystic ovary syndrome
ID MENDELIAN RANDOMIZATION ANALYSES; GENOME-WIDE ASSOCIATION;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; SIGNALING PATHWAY; OXIDATIVE
   STRESS; PCOS; EXPRESSION; TESTOSTERONE; INFLAMMATION
AB Polycystic ovary syndrome (PCOS) affects reproductive and cardiometabolic health, yet its pathogenesis remains unclear. Emerging evidence links hemoglobin levels to metabolic disorders, suggesting a potential role in PCOS development. Here, we integrated a large-scale cohort study, Mendelian randomization (A genetic tool to infer causal relationships), bioinformatics analyses, and in vitro experiments to investigate the relationship between hemoglobin levels and PCOS. In a cohort of 20 602 women, each 10 g L-1 elevation in hemoglobin levels is associated with 22% higher odds of PCOS (adjusted odds ratio: 1.22, 95% confidence interval: 1.15-1.29, P < 0.001) and PCOS manifestations, particularly hyperandrogenism. Mendelian randomization analysis confirms that higher hemoglobin levels are associated with increased PCOS risk and elevated testosterone levels. The hypoxia-inducible factor 1 (HIF-1) pathway is enriched, identifying three testosterone-associated genes (nuclear factor kappa B (NFKB1), insulin receptor (INSR), protein kinase C alpha. Colocalization and druggability analysis supports shared genetic regions and confirmed these genes as druggable targets. Upregulation of NFKB1 and INSR are confirmed in both blood and ovarian granulosa cells of PCOS patients. The findings demonstrate that higher-end normal hemoglobin levels are associated with increased PCOS risk, potentially through a mechanism of elevating testosterone levels involving the HIF-1 pathway.
C1 [Wang, Guiquan; Li, Ping] Xiamen Univ, Women & Childrens Hosp, Sch Med, Dept Reprod Med, Xiamen 361003, Peoples R China.
   [Wang, Guiquan; Li, Ping] Xiamen Key Lab Reprod & Genet, Xiamen 361023, Peoples R China.
   [Mao, Weian] Wenzhou Med Univ, Affiliated Hosp 2, Dept Obstet & Gynecol, Wenzhou 325027, Peoples R China.
   [Zhang, Yurong; Zhao, Yue] Peking Univ Third Hosp, Natl Clin Res Ctr Obstet & Gynecol, Ctr Reprod Med, Key Lab Assisted Reprod,Dept Obstet & Gynecol,Stat, Beijing 100191, Peoples R China.
   [Yang, Haiyan; Li, Yan] Wenzhou Med Univ, Affiliated Hosp 1, Reprod Med Ctr, Wenzhou 325000, Peoples R China.
   [Zhu, Ming; Chen, Yi; Lou, Chen] Wenzhou Med Univ, Sch Med 1, Wenzhou 325035, Peoples R China.
   [Chen, Wei; Mu, Liangshan] Fudan Univ, Zhongshan Hosp, Reprod Med Ctr, Shanghai 200032, Peoples R China.
   [Chang, Hsun-Ming] China Med Univ Hosp, Dept Obstet & Gynecol, Taichung 40400, Taiwan.
   [Yuan, Shuai] Karolinska Inst, Inst Environm Med, Unit Cardiovasc & Nutr Epidemiol, S-17177 Stockholm, Sweden.
C3 Xiamen University; Wenzhou Medical University; Wenzhou Medical
   University; Wenzhou Medical University; Fudan University; China Medical
   University Taiwan; China Medical University Hospital - Taiwan;
   Karolinska Institutet
RP Wang, GQ (corresponding author), Xiamen Univ, Women & Childrens Hosp, Sch Med, Dept Reprod Med, Xiamen 361003, Peoples R China.; Wang, GQ (corresponding author), Xiamen Key Lab Reprod & Genet, Xiamen 361023, Peoples R China.; Zhao, Y (corresponding author), Peking Univ Third Hosp, Natl Clin Res Ctr Obstet & Gynecol, Ctr Reprod Med, Key Lab Assisted Reprod,Dept Obstet & Gynecol,Stat, Beijing 100191, Peoples R China.; Mu, LS (corresponding author), Fudan Univ, Zhongshan Hosp, Reprod Med Ctr, Shanghai 200032, Peoples R China.
EM frank_sjtu@hotmail.com; zhaoyue0630@163.com;
   mu.liangshan@zs-hospital.sh.cn
RI Zhang, Yurong/LJK-1390-2024; Lou, Chen/MTG-3889-2025
OI Lou, Chen/0009-0009-7337-5800
FU National Key Research and Development Program of China; National Natural
   Science Foundation of China [82471670, 82071608, 82271665, 82401908];
   Key Clinical Projects of Peking University Third Hospital [BYSY2022043];
   Pilot Project-China Reproductive Health Public Welfare Foundation
   [SZ202414];  [2021YFC2700402]
FX The authors express their gratitude to the study participants, whose
   participation made this work possible, and to the numerous researchers
   who contributed to the collection, phenotypic characterization of
   clinical samples, and the analysis and public availability of data. This
   study was supported by the National Key Research and Development Program
   of China (2021YFC2700402), the National Natural Science Foundation of
   China (82471670, 82071608, 82271665, and 82401908), the Key Clinical
   Projects of Peking University Third Hospital (BYSY2022043), and the
   Pilot Project-China Reproductive Health Public Welfare Foundation
   (SZ202414). None of the funding sources in this study played a role in
   the study design, data collection, data analysis, interpretation, or
   manuscript writing. The authors consider that the first four authors
   should be regarded as joint First Authors.
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NR 80
TC 0
Z9 0
U1 8
U2 8
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
EI 2198-3844
J9 ADV SCI
JI Adv. Sci.
PD APR
PY 2025
VL 12
IS 14
DI 10.1002/advs.202411679
EA FEB 2025
PG 13
WC Chemistry, Multidisciplinary; Nanoscience & Nanotechnology; Materials
   Science, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Science & Technology - Other Topics; Materials Science
GA 1HZ1X
UT WOS:001421820900001
PM 39950870
OA gold
DA 2025-06-11
ER

PT J
AU Phung, HH
   Lee, CH
AF Hieu Huy Phung
   Lee, Chang Hoon
TI Mouse models of nonalcoholic steatohepatitis and their application to
   new drug development
SO ARCHIVES OF PHARMACAL RESEARCH
LA English
DT Review
DE Nonalcoholic steatohepatitis; Fibrosis; Hepatocellular carcinoma; Mouse
   models; Drug development
ID FATTY LIVER-DISEASE; DE-NOVO LIPOGENESIS; ENDOPLASMIC-RETICULUM-STRESS;
   CHOLINE-DEFICIENT DIET; PPAR-ALPHA AGONIST; HEPATIC STEATOSIS;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; MURINE MODEL; OBETICHOLIC ACID
AB Nonalcoholic steatohepatitis (NASH) is one of the important liver diseases currently attracting attention in liver research and drug development. Appropriate mouse models should be used to identify the mechanisms underlying the pathogenesis and progression of NASH in humans and to evaluate the efficacy of anti-NASH agents under development to treat this disease. In this review, we first summarised recent histopathology and pathogenesis of NASH in humans, including the concept of resolution of inflammation. We also examined whether these characteristics of NASH in humans are adequately reflected in mouse models. Through this review, we identified the usefulness and limitations of mouse models widely used in research on NASH. Mouse models can be divided into three main types: diet models, chemical models using toxic compounds, and genetic models using genetically transgenic mice. Genotype models are likely suitable for evaluating anti-NASH compounds because fibrosis, which is considered an important index to determine the drug efficacy of NASH inhibitors, is rapidly induced in genetic models. Using these models, we introduced some selected cases of NASH inhibitor development. This review aims to enhance the understanding of the pathogenesis of NASH and provide a basis for successfully selecting and utilising appropriate animal models of NASH in the development of effective inhibitors.
C1 [Hieu Huy Phung; Lee, Chang Hoon] Dongguk Univ, Coll Pharm, BK21 FOUR Team, Goyang 10326, South Korea.
   [Hieu Huy Phung; Lee, Chang Hoon] Dongguk Univ, Coll Pharm, Integrated Res Inst Drug Dev, Goyang 10326, South Korea.
C3 Dongguk University; Dongguk University
RP Lee, CH (corresponding author), Dongguk Univ, Coll Pharm, BK21 FOUR Team, Goyang 10326, South Korea.; Lee, CH (corresponding author), Dongguk Univ, Coll Pharm, Integrated Res Inst Drug Dev, Goyang 10326, South Korea.
EM uatheone@dongguk.edu
OI Lee, Chang Hoon/0000-0003-2210-0793; PHUNG, HUY HIEU/0000-0003-2523-6522
FU NRF - Ministry of Education (MOE, Korea) [NRF-2018R1A5A2023127,
   NRF-2020R1A2C3004973, NRF-2020M3E5E2038356]; Korea Health Industry
   Development Institute (KHIDI) - Ministry of Health Welfare, Korea
   [HP20C0131]
FX This study was supported by a grant from the Basic Science Research
   Program and the BK21 FOUR program through the NRF (NRF-2018R1A5A2023127,
   NRF-2020R1A2C3004973, and NRF-2020M3E5E2038356) funded by the Ministry
   of Education (MOE, Korea) and the Korea Health Technology R&D Project
   through the Korea Health Industry Development Institute (KHIDI) funded
   by the Ministry of Health & Welfare, Korea (HP20C0131).
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NR 293
TC 9
Z9 9
U1 4
U2 24
PU PHARMACEUTICAL SOC KOREA
PI SEOUL
PA 1489-3 SUHCHO-DONG, SUHCHO-KU, SEOUL 137-071, SOUTH KOREA
SN 0253-6269
EI 1976-3786
J9 ARCH PHARM RES
JI Arch. Pharm. Res.
PD NOV
PY 2022
VL 45
IS 11
BP 761
EP 794
DI 10.1007/s12272-022-01410-5
EA NOV 2022
PG 34
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 6M4AC
UT WOS:000877745100001
PM 36318445
DA 2025-06-11
ER

PT J
AU Palmiero, G
   Cesaro, A
   Vetrano, E
   Pafundi, PC
   Galiero, R
   Caturano, A
   Moscarella, E
   Gragnano, F
   Salvatore, T
   Rinaldi, L
   Calabrò, P
   Sasso, FC
AF Palmiero, Giuseppe
   Cesaro, Arturo
   Vetrano, Erica
   Pafundi, Pia Clara
   Galiero, Raffaele
   Caturano, Alfredo
   Moscarella, Elisabetta
   Gragnano, Felice
   Salvatore, Teresa
   Rinaldi, Luca
   Calabro, Paolo
   Sasso, Ferdinando Carlo
TI Impact of SGLT2 Inhibitors on Heart Failure: From Pathophysiology to
   Clinical Effects
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE SGLT2 inhibitors; heart failure; pathophysiology; type 2 diabetes;
   cardiovascular risk
ID COTRANSPORTER 2 INHIBITORS; TYPE-2 DIABETES-MELLITUS; TIGHT GLYCEMIC
   CONTROL; CARDIOVASCULAR-DISEASES; ARTERIAL STIFFNESS; METABOLIC
   SYNDROME; EJECTION FRACTION; NA+/H+ EXCHANGER; O-GLCNACYLATION;
   BLOOD-PRESSURE
AB Heart failure (HF) affects up to over 20% of patients with type 2 diabetes (T2DM), even more in the elderly. Although, in T2DM, both hyperglycemia and the proinflammatory status induced by insulin resistance are crucial in cardiac function impairment, SGLT2i cardioprotective mechanisms against HF are several. In particular, these beneficial effects seem attributable to the significant reduction of intracellular sodium levels, well-known to exert a cardioprotective role in the prevention of oxidative stress and consequent cardiomyocyte death. From a molecular perspective, patients' exposure to gliflozins' treatment mimics nutrient and oxygen deprivation, with consequent autophagy stimulation. This allows to maintain the cellular homeostasis through different degradative pathways. Thus, since their introduction in the clinical practice, the hypotheses on SGLT2i mechanisms of action have changed: from simple glycosuric drugs, with consequent glucose lowering, erythropoiesis enhancing and ketogenesis stimulating, to intracellular sodium-lowering molecules. This provides their consequent cardioprotective effect, which justifies its significant reduction in CV events, especially in populations at higher risk. Finally, the updated clinical evidence of SGLT2i benefits on HF was summarized. Thus, this review aimed to analyze the cardioprotective mechanisms of sodium glucose transporter 2 inhibitors (SGLT2i) in patients with HF, as well as their clinical impact on cardiovascular events.
C1 [Palmiero, Giuseppe; Cesaro, Arturo; Moscarella, Elisabetta; Gragnano, Felice; Calabro, Paolo] Univ Campania Luigi Vanvitelli, Dept Translat Med Sci, I-80131 Naples, Italy.
   [Cesaro, Arturo; Moscarella, Elisabetta; Gragnano, Felice; Calabro, Paolo] AORN St Anna & San Sebastiano, Div Cardiol, I-81100 Caserta, Italy.
   [Vetrano, Erica; Pafundi, Pia Clara; Galiero, Raffaele; Caturano, Alfredo; Rinaldi, Luca; Sasso, Ferdinando Carlo] Univ Campania Luigi Vanvitelli, Dept Adv Med & Surg Sci, I-80138 Naples, Italy.
   [Salvatore, Teresa] Univ Campania Luigi Vanvitelli, Dept Precis Med, I-80138 Naples, Italy.
C3 Universita della Campania Vanvitelli; Universita della Campania
   Vanvitelli; Universita della Campania Vanvitelli
RP Sasso, FC (corresponding author), Univ Campania Luigi Vanvitelli, Dept Adv Med & Surg Sci, I-80138 Naples, Italy.
EM g.palmiero@hotmail.it; arturo.cesaro@unicampania.it;
   erica.vetrano@unicampania.it; piaclara.pafundi@unicampania.it;
   raffaele.galiero@unicampania.it; alfredo.caturano@unicampania.it;
   elisabetta.moscarella@unicampania.it; felice.gragnano@unicampania.it;
   teresa.salvatore@unicampania.it; luca.rinaldi@unicampania.it;
   paolo.calabro@unicampania.it; ferdinandocarlo.sasso@unicampania.it
RI Cesaro, Arturo/AAD-3701-2019; Caturano, Alfredo/AAA-4014-2022;
   Moscarella, Elisabetta/AAG-8617-2021; Sasso, Ferdinando
   Carlo/AAE-5665-2019; Calabro, Paolo/AAC-2704-2022; Galiero,
   Raffaele/KTP-8361-2024; Palmiero, Giuseppe/I-1087-2019; Caturano,
   Alfredo/ACM-4169-2022; Gragnano, Felice/AAJ-2109-2020; PAFUNDI, PIA
   CLARA/GLN-5679-2022
OI Sasso, Ferdinando Carlo/0000-0002-9142-7848; calabro,
   paolo/0000-0002-5018-830X; Palmiero, Giuseppe/0000-0002-5102-7460;
   Caturano, Alfredo/0000-0001-7761-7533; Gragnano,
   Felice/0000-0002-6943-278X; PAFUNDI, PIA CLARA/0000-0002-0310-3529;
   Rinaldi, Luca/0000-0002-6541-3821; Cesaro, Arturo/0000-0003-4435-1235
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NR 170
TC 71
Z9 75
U1 0
U2 6
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD JUN
PY 2021
VL 22
IS 11
AR 5863
DI 10.3390/ijms22115863
PG 22
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA SQ1TP
UT WOS:000660142500001
PM 34070765
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Galicia-Garcia, U
   Benito-Vicente, A
   Jebari, S
   Larrea-Sebal, A
   Siddiqi, H
   Uribe, KB
   Ostolaza, H
   Martín, C
AF Galicia-Garcia, Unai
   Benito-Vicente, Asier
   Jebari, Shifa
   Larrea-Sebal, Asier
   Siddiqi, Haziq
   Uribe, Kepa B.
   Ostolaza, Helena
   Martin, Cesar
TI Pathophysiology of Type 2 Diabetes Mellitus
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE type 2 diabetes mellitus; insulin resistance; beta-cell; liver;
   adipocyte; muscle; cardiovascular disease; pathophysiology
ID CORONARY-HEART-DISEASE; DENSITY-LIPOPROTEIN-CHOLESTEROL; HUMAN
   SKELETAL-MUSCLE; TRIGLYCERIDE-RICH LIPOPROTEINS; HEPATIC
   INSULIN-RESISTANCE; C-REACTIVE PROTEIN; METABOLIC SYNDROME; BETA-CELL;
   CARDIOVASCULAR-DISEASE; OXIDATIVE STRESS
AB Type 2 Diabetes Mellitus (T2DM), one of the most common metabolic disorders, is caused by a combination of two primary factors: defective insulin secretion by pancreatic beta-cells and the inability of insulin-sensitive tissues to respond appropriately to insulin. Because insulin release and activity are essential processes for glucose homeostasis, the molecular mechanisms involved in the synthesis and release of insulin, as well as in its detection are tightly regulated. Defects in any of the mechanisms involved in these processes can lead to a metabolic imbalance responsible for the development of the disease. This review analyzes the key aspects of T2DM, as well as the molecular mechanisms and pathways implicated in insulin metabolism leading to T2DM and insulin resistance. For that purpose, we summarize the data gathered up until now, focusing especially on insulin synthesis, insulin release, insulin sensing and on the downstream effects on individual insulin-sensitive organs. The review also covers the pathological conditions perpetuating T2DM such as nutritional factors, physical activity, gut dysbiosis and metabolic memory. Additionally, because T2DM is associated with accelerated atherosclerosis development, we review here some of the molecular mechanisms that link T2DM and insulin resistance (IR) as well as cardiovascular risk as one of the most important complications in T2DM.
C1 Fdn Biofis Bizkaia, Barrio Sarriena S-N, Leioa 48940, Bizkaia, Spain.
   [Galicia-Garcia, Unai; Benito-Vicente, Asier; Jebari, Shifa; Larrea-Sebal, Asier; Ostolaza, Helena; Martin, Cesar] UPV, EHU, CSIC, Biofis Inst, Barrio Sarriena S-N, Leioa 48940, Bizkaia, Spain.
   [Benito-Vicente, Asier; Jebari, Shifa; Ostolaza, Helena; Martin, Cesar] Univ Basque Country, EHU, Dept Biochem & Mol Biol, Apdo 644, Bilbao 48080, Spain.
   [Siddiqi, Haziq] Havard Med Sch, 25 Shattuck St, Boston, MA 02115 USA.
   [Uribe, Kepa B.] Basque Res & Technol Alliance BRTA, Ctr Cooperat Res Biomat CIC biomaGUNE, Paseo Miramon 182, Donostia San Sebastian 20014, Spain.
C3 University of Basque Country; Consejo Superior de Investigaciones
   Cientificas (CSIC); University of Basque Country; CIC biomaGUNE
RP Martín, C (corresponding author), UPV, EHU, CSIC, Biofis Inst, Barrio Sarriena S-N, Leioa 48940, Bizkaia, Spain.; Martín, C (corresponding author), Univ Basque Country, EHU, Dept Biochem & Mol Biol, Apdo 644, Bilbao 48080, Spain.
EM u.galiciag@gmail.com; asier.benito@ehu.eus; sjebari001@ikasle.ehu.eus;
   asierlarrea@yahoo.es; siddiqi.haziq1@gmail.com;
   kbelloso@cicbiomagune.es; ofbmaplc@ehu.es; cesar.martin@ehu.eus
RI marttin, cesar/GWC-4638-2022; B. Uribe, Kepa/AGZ-5686-2022; martin,
   cesar/L-1303-2014
OI B. Uribe, Kepa/0000-0002-4502-4853; Larrea, Asier/0000-0001-9107-4299;
   martin, cesar/0000-0002-4087-8729; OSTOLAZA ECHABE,
   Helena/0000-0003-2933-9975
FU Basque Government [IT-1264-19]; Fundacion Biofisica Bizkaia; Programa de
   especializaci.n de Personal Investigador Doctor en la UPV/EHU (2019)
   2019-2020; Gobierno Vasco
FX This work was supported by the Basque Government (Grupos Consolidados
   IT-1264-19). U.G-G. was supported by Fundacion Biofisica Bizkaia.
   A.B.-V. was supported by Programa de especializaci.n de Personal
   Investigador Doctor en la UPV/EHU (2019) 2019-2020. S.J. and A.L.-S.
   were supported by a grant PIF (2017-2018) and (2019-2020), Gobierno
   Vasco, respectively. A.L-S. was partially supported by Fundacion
   Biofisica Bizkaia.
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NR 286
TC 1568
Z9 1712
U1 73
U2 644
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD SEP
PY 2020
VL 21
IS 17
AR 6275
DI 10.3390/ijms21176275
PG 34
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA NP1YX
UT WOS:000569977700001
PM 32872570
OA Green Published, Green Submitted, gold
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Beshbishy, AM
   Hetta, HF
   Hussein, DE
   Saati, AA
   Uba, CC
   Rivero-Perez, N
   Zaragoza-Bastida, A
   Shah, MA
   Behl, T
   Batiha, GE
AF Magdy Beshbishy, Amany
   Hetta, Helal F.
   Hussein, Diaa E.
   Saati, Abdullah A.
   C. Uba, Christian
   Rivero-Perez, Nallely
   Zaragoza-Bastida, Adrian
   Shah, Muhammad Ajmal
   Behl, Tapan
   Batiha, Gaber El-Saber
TI Factors Associated with Increased Morbidity and Mortality of Obese and
   Overweight COVID-19 Patients
SO BIOLOGY-BASEL
LA English
DT Review
DE obesity; COVID-19; coronaviruses; influenza; thrombosis
ID BODY-MASS INDEX; CORONAVIRUS DISEASE 2019; HUMAN ADENOVIRUS-36;
   INSULIN-RESISTANCE; IMMUNE-RESPONSE; RISK-FACTOR; SEASONAL INFLUENZA;
   METABOLIC SYNDROME; VIRUS-INFECTION; UNITED-STATES
AB Overweight and obesity are defined as an unnecessary accumulation of fat, which poses a risk to health. It is a well-identified risk factor for increased mortality due to heightened rates of heart disease, certain cancers, musculoskeletal disorders, and bacterial, protozoan and viral infections. The increasing prevalence of obesity is of concern, as conventional pathogenesis may indeed be increased in obese hosts rather than healthy hosts, especially during this COVID-19 pandemic. COVID-19 is a new disease and we do not have the luxury of cumulative data. Obesity activates the development of gene induced hypoxia and adipogenesis in obese animals. Several factors can influence obesity, for example, stress can increase the body weight by allowing people to consume high amounts of food with a higher propensity to consume palatable food. Obesity is a risk factor for the development of immune-mediated and some inflammatory-mediated diseases, including atherosclerosis and psoriasis, leading to a dampened immune response to infectious agents, leading to weaker post-infection impacts. Moreover, the obese host creates a special microenvironment for disease pathogenesis, marked by persistent low-grade inflammation. Therefore, it is advisable to sustain healthy eating habits by increasing the consumption of various plant-based and low-fat foods to protect our bodies and decrease the risk of infectious diseases, especially COVID-19.
C1 [Magdy Beshbishy, Amany] Obihiro Univ Agr & Vet Med, Natl Res Ctr Protozoan Dis, Nishi 2-13,Inada Cho, Obihiro, Hokkaido 0808555, Japan.
   [Hetta, Helal F.] Assiut Univ, Dept Med Microbiol & Immunol, Fac Med, Assiut 71515, Egypt.
   [Hetta, Helal F.] Univ Cincinnati, Dept Internal Med, Coll Med, Cincinnati, OH 45267 USA.
   [Hussein, Diaa E.] Agr Res Ctr ARC, Anim Hlth Res Inst, Dept Food Hyg, Port Of Alexandria 26514, Egypt.
   [Saati, Abdullah A.] Umm Al Qura Univ, Fac Med, Dept Community Med & Pilgrims Healthcare, Mecca 24382, Saudi Arabia.
   [C. Uba, Christian] Paul Univ, Dept Microbiol, PMB 6074, Awka, Anambra State, Nigeria.
   [Rivero-Perez, Nallely; Zaragoza-Bastida, Adrian] Univ Autonoma Estado Hidalgo, Inst Ciencias Agr, Area Acad Med Vet & Zootecnia, Av Univ Km 1, Tulancingo 43600, Hgo, Mexico.
   [Shah, Muhammad Ajmal] Govt Coll Univ, Fac Pharmaceut Sci, Dept Pharmacognosy, Faisalabad 38000, Pakistan.
   [Behl, Tapan] Chitkara Univ, Chitkara Coll Pharm, Rajpura 140401, Punjab, India.
   [Batiha, Gaber El-Saber] Damanhour Univ, Dept Pharmacol & Therapeut, Fac Vet Med, Damanhour 22511, Egypt.
C3 Obihiro University of Agriculture & Veterinary Medicine; Egyptian
   Knowledge Bank (EKB); Assiut University; University System of Ohio;
   University of Cincinnati; Animal Health Research Institute (AHRI); Umm
   Al-Qura University; Universidad Autonoma del Estado de Hidalgo;
   Government College University Faisalabad; Chitkara University, Punjab;
   Egyptian Knowledge Bank (EKB); Damanhour University
RP Beshbishy, AM (corresponding author), Obihiro Univ Agr & Vet Med, Natl Res Ctr Protozoan Dis, Nishi 2-13,Inada Cho, Obihiro, Hokkaido 0808555, Japan.; Hetta, HF (corresponding author), Assiut Univ, Dept Med Microbiol & Immunol, Fac Med, Assiut 71515, Egypt.; Hetta, HF (corresponding author), Univ Cincinnati, Dept Internal Med, Coll Med, Cincinnati, OH 45267 USA.; Batiha, GE (corresponding author), Damanhour Univ, Dept Pharmacol & Therapeut, Fac Vet Med, Damanhour 22511, Egypt.
EM amanimagdi2008@gmail.com; Helal.hetta@uc.edu; diaavet@hotmail.com;
   aaasaati@uqu.edu.sa; Christian.uba@pauluniversity.edu.ng;
   nallely_rivero@uaeh.edu.mx; adrian_zaragoza@uaeh.edu.mx;
   ajmalshah@gcuf.edu.pk; tapanbehl31@gmail.com; gaberbatiha@gmail.com
RI Saati, Abdullah/MNO-6902-2025; Hussein, Diaa Eldin/AHB-7269-2022;
   Zaragoza Bastida, Adrian/S-6834-2018; Hetta, Helal/U-6794-2019;
   Rivero-Perez, Nallely/S-6837-2018; Behl, Tapan/W-3523-2019; Shah,
   Muhammad Ajmal/M-7872-2015
OI Batiha, Gaber/0000-0002-7817-425X; Zaragoza Bastida,
   Adrian/0000-0002-8537-5025; Hussein, Diaa Eldin/0000-0001-9428-3221;
   Rivero-Perez, Nallely/0000-0002-6154-9983; Shah, Muhammad
   Ajmal/0000-0003-3471-184X; Hetta, Helal F./0000-0001-8541-7304; Saati,
   Abdullah/0000-0003-3766-9915
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NR 155
TC 28
Z9 28
U1 0
U2 7
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2079-7737
J9 BIOLOGY-BASEL
JI Biology-Basel
PD SEP
PY 2020
VL 9
IS 9
AR 280
DI 10.3390/biology9090280
PG 24
WC Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics
GA OE0QF
UT WOS:000580245700001
PM 32916925
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Acheampong, T
   Jiang, LH
   Ziogas, A
   Odegaard, AO
AF Acheampong, Teofilia
   Jiang, Luohua
   Ziogas, Argyrios
   Odegaard, Andrew O.
TI Multi-Systemic Biological Risk and Cancer Mortality: The NHANES III
   Study
SO SCIENTIFIC REPORTS
LA English
DT Article
ID NUTRITION EXAMINATION SURVEY; MIDLIFE WOMEN FINDINGS; ALLOSTATIC LOAD;
   NATIONAL SAMPLE; US ADULTS; LONGITUDINAL ANALYSIS; METABOLIC SYNDROME;
   DNA-DAMAGE; ALL-CAUSE; HEALTH
AB Multi-systemic biological risk (MSBR), a proxy for allostatic load, is a composite index of biomarkers representing dysregulation due to responses to chronic stress. This study examined the association of an MSBR index with cancer mortality. The sample included n = 13,628 adults aged 20-90 from the NHANES III Linked Mortality File (1988-1994). The MSBR index included autonomic (pulse rate, blood pressure), metabolic (HOMAir, triglycerides, waist circumference), and immune (white blood cell count, C-reactive protein) markers. We fit Cox proportional hazards models to estimate hazard ratios (HRs) and 95% confidence intervals (CI) of overall cancer mortality risk, according to quartiles (q) of the index. In multivariable models, compared to those in q1, q4 had a 64% increased risk for cancer mortality (HR = 1.64, 95% CI:1.13-2.40). The immune domain drove the association (HR per unit = 1.19, 95% CI:1.07-1.32). In stratified analyses, the HR for those with a BMI >= 25 was 1.12 per unit (95% CI:1.051.19) and those with a BMI < 25 was 1.04 per unit (95% CI:0.92-1.18). MSBR is positively associated with risk for cancer mortality in a US sample, particularly among those who are overweight or obese. The utilization of standard clinical measures comprising this index may inform population cancer prevention strategies.
C1 [Acheampong, Teofilia] Columbia Univ, Mailman Sch Publ Hlth, Dept Epidemiol, 722W 168th St, New York, NY 10032 USA.
   [Jiang, Luohua; Ziogas, Argyrios; Odegaard, Andrew O.] Univ Calif Irvine, Dept Epidemiol, Anteater Instruct & Res Bldg AIRB, Irvine, CA 92697 USA.
C3 Columbia University; University of California System; University of
   California Irvine
RP Odegaard, AO (corresponding author), Univ Calif Irvine, Dept Epidemiol, Anteater Instruct & Res Bldg AIRB, Irvine, CA 92697 USA.
EM aodegaar@uci.edu
OI Acheampong, Teofilia/0000-0003-4752-0081; Ziogas,
   Argyrios/0000-0003-4529-3727
CR Acheampong T, 2018, MULTISYSTEMIC BIOL R
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NR 75
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U1 0
U2 0
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD MAR 19
PY 2020
VL 10
IS 1
AR 5047
DI 10.1038/s41598-020-61945-9
PG 8
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Science & Technology - Other Topics
GA NF6YT
UT WOS:000563442500003
PM 32193496
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Centrone, M
   Gena, P
   Ranieri, M
   Di Mise, A
   D'Agostino, M
   Mastrodonato, M
   Venneri, M
   De Angelis, D
   Pavan, S
   Pasqualone, A
   Summo, C
   Fanelli, V
   Valenti, G
   Calamita, G
   Tamma, G
AF Centrone, Mariangela
   Gena, Patrizia
   Ranieri, Marianna
   Di Mise, Annarita
   D'Agostino, Mariagrazia
   Mastrodonato, Maria
   Venneri, Maria
   De Angelis, Davide
   Pavan, Stefano
   Pasqualone, Antonella
   Summo, Carmine
   Fanelli, Valentina
   Valenti, Giovanna
   Calamita, Giuseppe
   Tamma, Grazia
TI In Vitro and In Vivo Nutraceutical Characterization of Two Chickpea
   Accessions: Differential Effects on Hepatic Lipid Over-Accumulation
SO ANTIOXIDANTS
LA English
DT Article
DE legumes; liver; hepatic steatosis; lipid dyshomeostasis; ROS
ID HIGH-FAT-DIET; INCREASED OXIDATIVE STRESS; INSULIN-RESISTANCE; METABOLIC
   SYNDROME; INFLAMMATION; EXPRESSION; BENEFITS; DISEASE; GLUCOSE; OBESITY
AB Dietary habits are crucially important to prevent the development of lifestyle-associated diseases. Diets supplemented with chickpeas have numerous benefits and are known to improve body fat composition. The present study was undertaken to characterize two genetically and phenotypically distinct accessions, MG_13 and PI358934, selected from a global chickpea collection. Rat hepatoma FaO cells treated with a mixture of free fatty acids (FFAs) (O/P) were used as an in vitro model of hepatic steatosis. In parallel, a high-fat diet (HFD) animal model was also established. In vitro and in vivo studies revealed that both chickpea accessions showed a significant antioxidant ability. However, only MG_13 reduced the lipid over-accumulation in steatotic FaO cells and in the liver of HFD fed mice. Moreover, mice fed with HFD + MG_13 displayed a lower level of glycemia and aspartate aminotransferase (AST) than HFD mice. Interestingly, exposure to MG_13 prevented the phosphorylation of the inflammatory nuclear factor kappa beta (NF-kB) which is upregulated during HFD and known to be linked to obesity. To conclude, the comparison of the two distinct chickpea accessions revealed a beneficial effect only for the MG_13. These findings highlight the importance of studies addressing the functional characterization of chickpea biodiversity and nutraceutical properties.
C1 [Centrone, Mariangela; Gena, Patrizia; Ranieri, Marianna; Di Mise, Annarita; D'Agostino, Mariagrazia; Venneri, Maria; Valenti, Giovanna; Calamita, Giuseppe; Tamma, Grazia] Univ Bari Aldo Moro, Dept Biosci Biotechnol & Biopharmaceut, I-70125 Bari, Italy.
   [Mastrodonato, Maria] Univ Bari Aldo Moro, Dept Biol, I-70125 Bari, Italy.
   [De Angelis, Davide; Pavan, Stefano; Pasqualone, Antonella; Summo, Carmine; Fanelli, Valentina] Univ Bari Aldo Moro, Dept Soil Plant & Food Sci, I-70125 Bari, Italy.
   [Valenti, Giovanna; Calamita, Giuseppe; Tamma, Grazia] INBB, I-00136 Rome, Italy.
C3 Universita degli Studi di Bari Aldo Moro; Universita degli Studi di Bari
   Aldo Moro; Universita degli Studi di Bari Aldo Moro
RP Tamma, G (corresponding author), Univ Bari Aldo Moro, Dept Biosci Biotechnol & Biopharmaceut, I-70125 Bari, Italy.; Tamma, G (corresponding author), INBB, I-00136 Rome, Italy.
EM mariangela.centrone@uniba.it; annapatrizia.gena@uniba.it;
   marianna.ranieri@uniba.it; annarita.dimise@uniba.it;
   mariagrazia.dagostino@uniba.it; maria.mastrodonato@uniba.it;
   maria.venneri@uniba.it; davide.deangelis@uniba.it;
   stefano.pavan@uniba.it; antonella.pasqualone@uniba.it;
   carmine.summo@uniba.it; valentina.fanelli@uniba.it;
   giovanna.valenti@uniba.it; giuseppe.calamita@uniba.it;
   grazia.tamma@uniba.it
RI De Angelis, Davide/ABD-7045-2020; Carmine, Summo/ABC-6239-2021; Tamma,
   Grazia/F-8823-2016; Pasqualone, Antonella/H-7820-2019; Di Mise,
   Annarita/AAP-4176-2020; Centrone, Mariangela/JHS-9644-2023; Gena,
   patrizia/AAC-3396-2022; mastrodonato, Maria/P-4513-2016; D'Agostino,
   Mariagrazia/AIA-0820-2022; Fanelli, Valentina/AAB-3415-2020; pavan,
   stefano/AAA-4927-2020; Venneri, Maria/AIB-6844-2022; RANIERI,
   Marianna/J-9421-2018
OI De Angelis, Davide/0000-0001-6048-9248; Venneri,
   Maria/0000-0002-1235-6157; Pavan, Stefano/0000-0002-3666-7291; Calamita,
   Giuseppe/0000-0003-4666-9546; RANIERI, Marianna/0000-0003-3118-5813;
   Centrone, Mariangela/0000-0001-5469-3365; DI MISE,
   Annarita/0000-0002-8132-4917; D'Agostino,
   Mariagrazia/0000-0001-6127-9656; Tamma, Grazia/0000-0002-8890-0278;
   Pasqualone, Antonella/0000-0001-6675-2203
FU project "LegumeGEneticREsources as a tool for the development of
   innovative and sustainable food TEchnological system" under the "Thought
   for Food" Initiative by the Agropolis Foundation
   ("Investissementsd'avenir" programme) [ANR-10-LABX-0001-01]
FX This research has been performed within the project
   "LegumeGEneticREsources as a tool for the development of innovative and
   sustainable food TEchnological system" supported under the "Thought for
   Food" Initiative by the Agropolis Foundation (through
   the"Investissementsd'avenir" programme with reference number
   ANR-10-LABX-0001-01), the Fondazione Cariplo, and the Daniel & Nina
   Carasso Foundation.
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NR 44
TC 12
Z9 12
U1 1
U2 10
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD MAR
PY 2020
VL 9
IS 3
AR 268
DI 10.3390/antiox9030268
PG 16
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA LB2UG
UT WOS:000524490700062
PM 32214012
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Ibrahim, KG
   Wright, HL
   Chivandi, E
   Madziva, MT
   Erlwanger, KH
AF Ibrahim, Kasimu G.
   Wright, Hayley L.
   Chivandi, Eliton
   Madziva, Michael T.
   Erlwanger, Kennedy H.
TI The potential developmental programming effect of oral curcumin on the
   bone health and plasma total osteocalcin of male and female rats fed a
   high-fructose diet during suckling and post weaning
SO GENERAL PHYSIOLOGY AND BIOPHYSICS
LA English
DT Article
DE Bone health; Metabolic syndrome; Childhood obesity; Plasma osteocalcin
   levels
ID INSULIN-RESISTANCE; DIABETES-MELLITUS; OXIDATIVE STRESS; BODY-WEIGHT;
   OBESITY; OSTEOPOROSIS; CONSUMPTION; PREVENTION; MASS; AGE
AB We investigated the effect of oral curcumin on bone health of rats fed a high-fructose diet. Suckling pups (males = 65, females = 63) were gavaged with 0.5% DMSO, curcumin (500 mg/kg), fructose (20%, w/v) or a combination of curcumin and fructose daily from postnatal days 6 to 21. Then the rats were weaned onto normal rat feed for six weeks and each group was sub-divided into two subgroups: one had plain tap water and the other had fructose (20%, w/v) to drink. Blood was assayed for plasma total osteocalcin. Morphometry and radiographic bone density assessments were made on the femora and tibiae. The lengths, masses and Seedor indices of the bones were similar (p > 0.05, ANOVA) across the groups. Males that received curcumin with or without fructose during suckling and weaned onto a high-fructose diet had lower (p <= 0.05, ANOVA) osteocalcin concentration versus the other males. Similarly, in female rats, curcumin alone or administered with fructose resulted in lower (p <= 0.05, ANOVA) osteocalcin concentration versus female rats administered the vehicle control. Neonatal curcumin-induced decrease in plasma total osteocalcin concentration may predispose to adverse consequences on glucose metabolism and bone health.
C1 [Ibrahim, Kasimu G.; Wright, Hayley L.; Chivandi, Eliton; Madziva, Michael T.; Erlwanger, Kennedy H.] Univ Witwatersrand, Fac Hlth Sci, Sch Physiol, Johannesburg, South Africa.
   [Ibrahim, Kasimu G.] Usmanu Danfodiyo Univ, Coll Hlth Sci, Fac Basic Med Sci, Dept Physiol, PMB 2254, Sokoto, Nigeria.
C3 University of Witwatersrand
RP Ibrahim, KG (corresponding author), Usmanu Danfodiyo Univ, Coll Hlth Sci, Fac Basic Med Sci, Dept Physiol, PMB 2254, Sokoto, Nigeria.
EM ghandi.kasimu@udusok.edu.ng
RI Chivandi, Eliton/AGY-4144-2022; Erlwanger, Kennedy/AAX-2616-2020;
   Ghandi, Kasimu/L-7904-2017
OI Ghandi, Kasimu/0000-0002-2119-580X; Chivandi,
   Eliton/0000-0003-0386-4245; Madziva, Michael/0009-0004-7482-0404
FU Faculty of Health Sciences, University of the Witwatersrand medical
   research endowment fund
   [001.251.8521101.5121105.000000.0000000000.4550]; National Research
   Foundation of South Africa [IRF 2010041900009]
FX The authors acknowledge the technical support received from Ms Monica
   Gomes and staff of the Central Animal Services of the University of the
   Witwatersrand, Johannesburg. This study was funded by the Faculty of
   Health Sciences, University of the Witwatersrand medical research
   endowment fund (KGI, Grant number:
   001.251.8521101.5121105.000000.0000000000.4550) and the National
   Research Foundation of South Africa (KHE, Grant number: IRF
   2010041900009).
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NR 54
TC 2
Z9 2
U1 0
U2 6
PU GENERAL PHYSIOL AND BIOPHYSICS
PI BRATISLAVA
PA INST OF MOLEC PHYSIOL GENETICS SLOVAK ACAD OF SCI VLARSKA 5, 83334
   BRATISLAVA, SLOVAKIA
SN 0231-5882
EI 1338-4325
J9 GEN PHYSIOL BIOPHYS
JI Gen. Physiol. Biophys.
PY 2019
VL 38
IS 5
BP 435
EP 444
DI 10.4149/gpb_2019025
PG 10
WC Biochemistry & Molecular Biology; Biophysics; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Physiology
GA JC9RS
UT WOS:000489614600008
PM 31411571
OA gold
DA 2025-06-11
ER

PT J
AU Pruimboom, L
   Muskiet, FAJ
AF Pruimboom, Leo
   Muskiet, Frits A. J.
TI Intermittent living; the use of ancient challenges as a vaccine against
   the deleterious effects of modern life - A hypothesis
SO MEDICAL HYPOTHESES
LA English
DT Article
DE Evolution; Intermittent; Hormesis; Hypoxia; Hypercapnia; Vaccine;
   Chronic; Low grade inflammation; Fasting; Preconditioning
ID OBSTRUCTIVE PULMONARY-DISEASE; RNA-BINDING PROTEIN; RANDOMIZED
   CONTROLLED-TRIAL; INNATE IMMUNE-RESPONSE; BROWN ADIPOSE-TISSUE; ONE-LUNG
   VENTILATION; HEAT-SHOCK PROTEINS; AMBIENT-TEMPERATURE; METABOLIC
   SYNDROME; FOOD DIVERSITY
AB Chronic non-communicable diseases (CNCD) are the leading cause of mortality in developed countries. They ensue from the sum of modern anthropogenic risk factors, including high calorie nutrition, malnutrition, sedentary lifestyle, social stress, environmental toxins, politics and economic factors. Many of these factors are beyond the span of control of individuals, suggesting that CNCD are inevitable. However, various studies, ours included, show that the use of intermittent challenges with hormetic effects improve subjective and objective wellbeing of individuals with CNCD, while having favourable effects on immunological, metabolic and behavioural indices. Intermittent cold, heat, fasting and hypoxia, together with phytochemicals in multiple food products, have widespread influence on many pathways related with overall health. Until recently, most of the employed challenges with hormetic effects belonged to the usual transient live experiences of our ancestors. Our hypothesis; we conclude that, whereas the total inflammatory load of multi-metabolic and psychological risk factors causes low grade inflammation and aging, the use of intermittent challenges, united in a 7-10 days lasting hormetic intervention, might serve as a vaccine against the deleterious effects of chronic low grade inflammation and it's metabolic and (premature) aging consequences.
C1 [Pruimboom, Leo] Natura Fdn, Numansdorp, Netherlands.
   [Muskiet, Frits A. J.] Univ Groningen, Univ Med Ctr Groningen, Lab Med, Groningen, Netherlands.
C3 University of Groningen
RP Pruimboom, L (corresponding author), Natura Fdn, Numansdorp, Netherlands.
EM cpni.pruimboom@icloud.com
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NR 238
TC 18
Z9 19
U1 0
U2 7
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0306-9877
EI 1532-2777
J9 MED HYPOTHESES
JI Med. Hypotheses
PD NOV
PY 2018
VL 120
BP 28
EP 42
DI 10.1016/j.mehy.2018.08.002
PG 15
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Research & Experimental Medicine
GA GW6UZ
UT WOS:000447100300006
PM 30220336
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Byrd, AS
   Toth, AT
   Stanford, FC
AF Byrd, Angel S.
   Toth, Alexander T.
   Stanford, Fatima Cody
TI Racial Disparities in Obesity Treatment
SO CURRENT OBESITY REPORTS
LA English
DT Article
DE Obesity; Overweight; Race; Ethnicity; Genetics; Weight loss medications;
   Bariatric surgery; Disparities; Socioeconomic status
ID BODY-MASS INDEX; LIFE-STYLE INTERVENTION; FAST-FOOD INTAKE; CHILDHOOD
   OBESITY; WEIGHT-LOSS; BARIATRIC SURGERY; PHYSICAL-ACTIVITY;
   RACIAL/ETHNIC DISPARITIES; METABOLIC SYNDROME; RISK-FACTORS
AB Purpose of Review Obesity rates in the USA have reached pandemic levels with one third of the population with obesity in 20152016 (39.8% of adults and 18.5% of youth). It is a major public health concern, and it is prudent to understand the factors which contribute. Racial and ethnic disparities are pronounced in both the prevalence and treatment of obesity and must be addressed in the efforts to combat obesity.
   Recent Findings Disparities in prevalence of obesity in racial/ethnic minorities are apparent as early as the preschool years and factors including genetics, diet, physical activity, psychological factors, stress, income, and discrimination, among others, must be taken into consideration. A multidisciplinary team optimizes lifestyle and behavioral interventions, pharmacologic therapy, and access to bariatric surgery to develop the most beneficial and equitable treatment plans.
   Summary The reviewed studies outline disparities that exist and the impact that race/ethnicity have on disease prevalence and treatment response. Higher prevalence and reduced treatment response to lifestyle, behavior, pharmacotherapy, and surgery, are observed in racial and ethnic minorities. Increased research, diagnosis, and access to treatment in the pediatric and adult populations of racial and ethnic minorities are proposed to combat the burgeoning obesity epidemic and to prevent increasing disparity.
C1 [Byrd, Angel S.] Johns Hopkins Univ, Sch Med, Dept Dermatol, Baltimore, MD 21205 USA.
   [Toth, Alexander T.] Massachusetts Gen Hosp, Neuroendocrine Unit, Boston, MA 02114 USA.
   [Stanford, Fatima Cody] Harvard Med Sch, Boston, MA 02115 USA.
   [Stanford, Fatima Cody] Massachusetts Gen Hosp, Dept Med, MGH Weight Ctr, Gastrointestinal Unit, 50 Staniford St,Suite 430, Boston, MA 02114 USA.
   [Stanford, Fatima Cody] Massachusetts Gen Hosp, Dept Pediat Endocrinol, Boston, MA 02114 USA.
C3 Johns Hopkins University; Harvard University; Harvard University Medical
   Affiliates; Massachusetts General Hospital; Harvard University; Harvard
   Medical School; Harvard University; Harvard University Medical
   Affiliates; Massachusetts General Hospital; Harvard University; Harvard
   University Medical Affiliates; Massachusetts General Hospital
RP Stanford, FC (corresponding author), Harvard Med Sch, Boston, MA 02115 USA.; Stanford, FC (corresponding author), Massachusetts Gen Hosp, Dept Med, MGH Weight Ctr, Gastrointestinal Unit, 50 Staniford St,Suite 430, Boston, MA 02114 USA.; Stanford, FC (corresponding author), Massachusetts Gen Hosp, Dept Pediat Endocrinol, Boston, MA 02114 USA.
EM fstanford@mgh.harvard.edu
RI Stanford, Fatima/H-3953-2019
OI Stanford, Fatima/0000-0003-4616-533X
FU National Institutes of Health NIDDK [R01 DK103946-01A1]
FX National Institutes of Health NIDDK R01 DK103946-01A1.
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NR 92
TC 156
Z9 179
U1 0
U2 33
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 2162-4968
J9 CURR OBES REP
JI Curr. Obes. Rep.
PD JUN
PY 2018
VL 7
IS 2
BP 130
EP 138
DI 10.1007/s13679-018-0301-3
PG 9
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA GG3XX
UT WOS:000432628100006
PM 29616469
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Ren, X
   Li, C
   Liu, JL
   Zhang, CH
   Fu, YZ
   Wang, NN
   Ma, HY
   Lu, HY
   Kong, H
   Kong, L
AF Ren, Xiang
   Li, Chen
   Liu, Junli
   Zhang, Chenghong
   Fu, Yuzhen
   Wang, Nina
   Ma, Haiying
   Lu, Heyuan
   Kong, Hui
   Kong, Li
TI Thioredoxin plays a key role in retinal neuropathy prior to endothelial
   damage in diabetic mice
SO ONCOTARGET
LA English
DT Article
DE thioredoxin; diabetes; retina; apoptosis; sulforaphane
ID GLYCATION END-PRODUCT; INTERACTING PROTEIN; UP-REGULATION; OXIDATIVE
   STRESS; NRF2 EXPRESSION; BETA-CELLS; APOPTOSIS; SULFORAPHANE;
   RETINOPATHY; KINASE
AB Diabetes is a chronic metabolic syndrome that results in changes in carbohydrate, lipid and protein metabolism. With diabetes for a long time, it increases the risk of diabetic retinopathy (DR) and long-term morbidity and mortality. Moreover, emerging evidence suggests that neuron damage occurs earlier than microvascular complications in DR patients, but the underlying mechanism is unclear. We investigated diabetes-induced retinal neuropathy and elucidated key molecular events to identify new therapeutic targets for the clinical treatment and prevention of DR. For in vivo studies, a high-fat diet and streptozotocin (STZ) injection were used to generate the diabetes model. Hematoxylin-eosin staining was used for morphological observations and measurements of the outer nuclear layer thickness. Electroretinography (ERG) was used to assess retinal function. For in vitro studies, Neuro2a cells were incubated in normal (5.5 mM) and high-glucose (30 mM) conditions. Flow cytometry assays were performed to analyze apoptosis. Additionally, real-time PCR and Western blotting analyses were carried out to determine gene and protein expression in vitro and in vivo. Taken together, the results indicated that retinal neuropathy occurred prior to endothelial damage induced by diabetes, and thioredoxin (Trx) plays a key role in this process. This underlying mechanism may be related to activation of the Trx/ASK1/p-p38/Trx-interacting protein pathway.
C1 [Ren, Xiang; Li, Chen; Liu, Junli; Zhang, Chenghong; Fu, Yuzhen; Wang, Nina; Ma, Haiying; Lu, Heyuan; Kong, Li] Dalian Med Univ, Dept Histol & Embryol, Dalian 116044, Liaoning, Peoples R China.
   [Kong, Hui] Dalian Med Univ, Dept Otorhinolaryngol, Hosp 2, Dalian 116023, Liaoning, Peoples R China.
C3 Dalian Medical University; Dalian Medical University
RP Kong, L (corresponding author), Dalian Med Univ, Dept Histol & Embryol, Dalian 116044, Liaoning, Peoples R China.; Kong, H (corresponding author), Dalian Med Univ, Dept Otorhinolaryngol, Hosp 2, Dalian 116023, Liaoning, Peoples R China.
EM konghui6905@163.com; kongli@dmu.edu.cn
RI ren, xiang/HLQ-5068-2023
FU National Natural Science Foundation of China [31371218, 31300812];
   Natural Science Foundation of Liaoning province [2014023027]; China
   Postdoctoral Science Foundation [2014M551101]
FX We thank Dr. Hiroshi Masutani (Japan) for providing the Trx-shRNA
   vectors. This work was supported by Grant Nos. 31371218 and 31300812
   from the National Natural Science Foundation of China, Grant No.
   2014023027 from the Natural Science Foundation of Liaoning province and
   Grant No. 2014M551101 from the China Postdoctoral Science Foundation.
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NR 63
TC 24
Z9 25
U1 0
U2 10
PU IMPACT JOURNALS LLC
PI ORCHARD PARK
PA 6666 E QUAKER ST, STE 1, ORCHARD PARK, NY 14127 USA
EI 1949-2553
J9 ONCOTARGET
JI Oncotarget
PD SEP 5
PY 2017
VL 8
IS 37
BP 61350
EP 61364
DI 10.18632/oncotarget.18134
PG 15
WC Oncology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Cell Biology
GA FF8GI
UT WOS:000409254200048
PM 28977868
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Furusawa, Y
   Uruno, A
   Yagishita, Y
   Higashi, C
   Yamamoto, M
AF Furusawa, Yuki
   Uruno, Akira
   Yagishita, Yoko
   Higashi, Chika
   Yamamoto, Masayuki
TI Nrf2 induces fibroblast growth factor 21 in diabetic mice
SO GENES TO CELLS
LA English
DT Article
ID DIET-INDUCED OBESITY; ACTIVATED-RECEPTOR-GAMMA; PPAR-ALPHA; METABOLIC
   SYNDROME; KEAP1-NRF2 SYSTEM; STRESS-RESPONSE; BETA-KLOTHO; FGF21;
   EXPRESSION; ANTIOXIDANT
AB Transcription factor Nrf2 (nuclear factor E2-related factor 2) is a master regulator of cellular defense system against oxidative and electrophilic stresses and is negatively regulated by an adaptor protein Keap1 (Kelch-like ECH-associated protein 1). Nrf2 also plays a pivotal role in metabolic homeostasis, such as lipid metabolism and energy expenditure as well as redox homeostasis. FGF21 (fibroblast growth factor 21) is known as a key mediator of glucose and lipid metabolism. Here, we found that Nrf2 is involved in FGF21 regulation in diabetic model mice. Nrf2 induction by genetic knockdown of Keap1 increased plasma FGF21 level and hepatic Fgf21 expression in diabetic db/db mice and high-calorie-diet-induced obesity model mice. Administration of CDDO-Im (oleanolic triterpenoid 1-[2-cyano-3,12-dioxooleane-1, 9(11)-dien-28-oyl] imidazole), a potent Nrf2 inducer, up-regulated plasma FGF21 level and hepatic Fgf21 expression in db/db mice, whereas CDDO-Im did not induce FGF21 in db/db mice with Nrf2 knockout background. Furthermore, in Keap1-knockdown db/db mice, Nrf2 enhanced expression of glucose-and lipid-metabolism-related genes in adipose tissues, which improved plasma lipid profiles. These results show that Nrf2 positively regulates FGF21 expression in diabetic mice. We propose that FGF21 is a potential efficacy biomarker that mediates metabolic regulation by the Keap1-Nrf2 system.
C1 [Furusawa, Yuki; Uruno, Akira; Yagishita, Yoko; Higashi, Chika; Yamamoto, Masayuki] Tohoku Univ, Grad Sch Med, Dept Med Biochem, Aoba Ku, Sendai, Miyagi 9808575, Japan.
   [Furusawa, Yuki; Higashi, Chika] Mochida Pharmaceut Co Ltd, Pharmaceut Res Ctr, Gotemba, Shizuoka 4128524, Japan.
C3 Tohoku University; Mochida Pharmaceutical Co Ltd
RP Yamamoto, M (corresponding author), Tohoku Univ, Grad Sch Med, Dept Med Biochem, Aoba Ku, 2-1 Seiryo Machi, Sendai, Miyagi 9808575, Japan.
EM uruno@med.tohoku.ac.jp; masiyamamoto@med.tohoku.ac.jp
RI Yamamoto, Masayuki/A-4873-2010; Uruno, Akira/U-1812-2019; Yagishita,
   Yoko/ABG-5757-2020
FU Ministry of Education, Science, Sports and Culture (MEXT); create
   revolutionary technological seeds for science and technology innovation
   (CREST) from JST; Japan Society for the Promotion of Science (JSPS)
   [24249015, 90396474]; Takeda Foundation; Naito Foundation; Japanese
   Foundation for Applied Enzymology; Mochida Pharmaceutical Co., Ltd.
FX We thank Ms Sayoi Inomata (Tohoku University) for technical assistance
   and Biomedical Research Core of Tohoku University Graduate School of
   Medicine for technical support. This work was supported by the
   Grants-in-Aids for Scientific Research on Innovative Areas and
   Scientific Research from the Ministry of Education, Science, Sports and
   Culture (MEXT) (M.Y.), create revolutionary technological seeds for
   science and technology innovation (CREST) from JST (M.Y.),
   Grants-in-Aids for Scientific Research from the Japan Society for the
   Promotion of Science (JSPS) (Number 24249015 (M.Y.) and 90396474 (A.
   U.)), the Takeda Foundation (M.Y.), the Naito Foundation (M.Y.) and the
   Japanese Foundation for Applied Enzymology (A. U.). Y.F. and C. H. are
   employees of Mochida Pharmaceutical Co. Ltd. M.Y. has received grant
   support from Mochida Pharmaceutical Co., Ltd. No other potential
   conflicts of interest relevant to this article were reported.
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   Zhang DD, 2004, MOL CELL BIOL, V24, P10941, DOI 10.1128/MCB.24.24.10941-10953.2004
   Zhang Jian, 2008, Nutr Res Pract, V2, P200, DOI 10.4162/nrp.2008.2.4.200
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NR 56
TC 55
Z9 66
U1 0
U2 16
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1356-9597
EI 1365-2443
J9 GENES CELLS
JI Genes Cells
PD DEC
PY 2014
VL 19
IS 12
BP 864
EP 878
DI 10.1111/gtc.12186
PG 15
WC Cell Biology; Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Genetics & Heredity
GA AU2JD
UT WOS:000345443100002
PM 25270507
OA Bronze
DA 2025-06-11
ER

PT J
AU Docherty, NG
   Murphy, M
   Martin, F
   Brennan, EP
   Godson, C
AF Docherty, Neil G.
   Murphy, Madeline
   Martin, Finian
   Brennan, Eoin P.
   Godson, Catherine
TI Targeting cellular drivers and counter-regulators of hyperglycaemia-and
   transforming growth factor-β1-associated profibrotic responses in
   diabetic kidney disease
SO EXPERIMENTAL PHYSIOLOGY
LA English
DT Article
ID INTENSIVE GLUCOSE CONTROL; ALTERED GENE-EXPRESSION; PROTEIN-KINASE-A;
   RENAL FIBROSIS; MESANGIAL CELLS; OXIDATIVE STRESS; FACTOR-BETA;
   EPIGENETIC CHANGES; METABOLIC SYNDROME; PROXIMAL TUBULE
AB Diabetic kidney disease occurs in > 30% of patients with type 2 diabetes mellitus and is characterized at source by a maladaptive response in the renal parenchyma to exposure to a glucotoxic-lipotoxic diabetic milieu that courses coincident with hypertension. The consequence of these maladaptive responses is progressive renal injury, which is exacerbated by the development of a chronic inflammatory infiltrate associated with the development of tubulointerstitial fibrosis. The evolution of tubulointerstitial fibrosis is correlated with the loss of functional renal mass and descent towards renal failure. Transforming growth factor-beta 1 (TGF-beta 1) is a recognized mediator of the profibrotic response of mesangial cells and renal tubular epithelial cells to hyperglycaemia. While euglycaemia remains the goal in the treatment of type 2 diabetes mellitus, the prevention, arrest and reversal of microvascular complications, such as diabetic kidney disease, may be assisted by pharmacological modulation of the effectors of glucotoxicity, such as TGF-beta 1. This review focuses on describing how, through reductionist in vitro experimentation focusing on TGF-beta 1-related responses to hyperglycaemia, we have identified induced in high glucose-1 (IHG-1), induced in high glucose-2 (IHG-2/Grem1) and the lipoxin-inducible microRNA let-7c as potential targets for harnessing new therapeutic approaches to limit the bioactivity of TGF-beta 1 in diabetic kidney disease.
C1 [Docherty, Neil G.; Murphy, Madeline; Martin, Finian; Brennan, Eoin P.; Godson, Catherine] Univ Coll Dublin, Diabet Complicat Res Ctr, Conway Inst Biomol & Biomed Res, Sch Med & Med Sci, Dublin 4, Ireland.
   [Brennan, Eoin P.] Baker IDI Heart & Diabet Inst, Melbourne, Vic, Australia.
C3 University College Dublin; Baker Heart and Diabetes Institute
RP Docherty, NG (corresponding author), Univ Coll Dublin, Diabet Complicat Res Ctr, Conway Inst Biomol & Biomed Res, Sch Med & Med Sci, Dublin 4, Ireland.
EM neil.docherty@ucd.ie
OI Docherty, Neil/0000-0002-0961-2607; Godson,
   Catherine/0000-0003-0655-1041; Murphy, Madeline/0000-0001-9891-481X;
   Brennan, Eoin/0000-0003-4908-5474
FU Science Foundation Ireland [06/IN.1/B114, 08/US/B1517]; NIDDK Diabetes
   Complications Consortium Pilot & Feasibility Program; Science Foundation
   Ireland (SFI) [06/IN.1/B114, 08/US/B1517] Funding Source: Science
   Foundation Ireland (SFI)
FX Work in the authors' laboratory is supported by Science Foundation
   Ireland grants 06/IN.1/B114, 08/US/B1517 and The NIDDK Diabetes
   Complications Consortium Pilot & Feasibility Program.
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NR 58
TC 8
Z9 10
U1 0
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0958-0670
EI 1469-445X
J9 EXP PHYSIOL
JI Exp. Physiol.
PD SEP 1
PY 2014
VL 99
IS 9
SI SI
BP 1154
EP 1162
DI 10.1113/expphysiol.2014.078774
PG 9
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA AQ5BI
UT WOS:000342817000011
PM 25085843
OA Bronze
DA 2025-06-11
ER

PT J
AU Zhang, L
   Meng, S
   Tu, QS
   Yu, LM
   Tang, Y
   Dard, MM
   Kim, SH
   Valverde, P
   Zhou, XD
   Chen, JK
AF Zhang, Lan
   Meng, Shu
   Tu, Qisheng
   Yu, Liming
   Tang, Yin
   Dard, Michel M.
   Kim, Sung-Hoon
   Valverde, Paloma
   Zhou, Xuedong
   Chen, Jake
TI Adiponectin Ameliorates Experimental Periodontitis in Diet-Induced
   Obesity Mice
SO PLOS ONE
LA English
DT Article
ID MAPK SIGNALING PATHWAY; INSULIN-RESISTANCE; OXIDATIVE STRESS;
   PLASMA-CONCENTRATIONS; GLOBULAR ADIPONECTIN; METABOLIC SYNDROME; HUMAN
   OSTEOBLASTS; BONE LOSS; EXPRESSION; PROTEIN
AB Adiponectin is an adipokine that sensitizes the body to insulin. Low levels of adiponectin have been reported in obesity, diabetes and periodontitis. In this study we established experimental periodontitis in male adiponectin knockout and diet-induced obesity mice, a model of obesity and type 2 diabetes, and aimed at evaluating the therapeutic potential of adiponectin. We found that systemic adiponectin infusion reduced alveolar bone loss, osteoclast activity and infiltration of inflammatory cells in both periodontitis mouse models. Furthermore, adiponectin treatment decreased the levels of pro-inflammatory cytokines in white adipose tissue of diet-induced obesity mice with experimental periodontitis. Our in vitro studies also revealed that forkhead box O1, a key transcriptional regulator of energy metabolism, played an important role in the direct signaling of adiponectin in osteoclasts. Thus, adiponectin increased forkhead box O1 mRNA expression and its nuclear protein level in osteoclast-precursor cells undergoing differentiation. Inhibition of c-Jun N-terminal kinase signaling decreased nuclear protein levels of forkhead box O1. Furthermore, over-expression of forkhead box O1 inhibited osteoclastogenesis and led to decreased nuclear levels of nuclear factor of activated T cells c1. Taken together, this study suggests that systemic adiponectin application may constitute a potential intervention therapy to ameliorate type 2 diabetes-associated periodontitis. It also proposes that adiponectin inhibition of osteoclastogenesis involves forkhead box O1.
C1 [Zhang, Lan; Meng, Shu; Tu, Qisheng; Yu, Liming; Tang, Yin; Chen, Jake] Tufts Univ, Sch Dent Med, Div Oral Biol, Boston, MA 02111 USA.
   [Zhang, Lan; Meng, Shu; Tang, Yin; Zhou, Xuedong] Sichuan Univ, West China Hosp Stomatol, Key Lab Oral Dis, Chengdu 610064, Sichuan, Peoples R China.
   [Dard, Michel M.] NYU, Coll Dent, New York, NY USA.
   [Kim, Sung-Hoon] Kyung Hee Univ, Coll Oriental Med, Canc Prevent Mat Dev Res Ctr, Seoul, South Korea.
   [Kim, Sung-Hoon] Kyung Hee Univ, Coll Oriental Med, Seoul, South Korea.
   [Valverde, Paloma] Wentworth Inst Technol, Dept Sci, Boston, MA USA.
   [Chen, Jake] Tufts Univ, Sch Med, Sackler Sch Grad Biomed Sci, Dept Anat & Cell Biol, Boston, MA 02111 USA.
C3 Tufts University; Sichuan University; New York University; Kyung Hee
   University; Kyung Hee University; Tufts University
RP Tu, QS (corresponding author), Tufts Univ, Sch Dent Med, Div Oral Biol, Boston, MA 02111 USA.
EM qisheng.tu@tufts.edu; jk.chen@tufts.edu
RI Liming, Yu/Y-4291-2019; tang, yin/AAR-2123-2021; Chen, Jake/A-2857-2009;
   Zhou, Xuedong/LSL-0410-2024
OI Zhou, Xuedong/0000-0002-9319-7302; Zhang, Lan/0000-0002-9714-999X; Tu,
   Qisheng/0000-0003-0639-8761; kim, sunghoon/0000-0002-1570-3230
FU National Institutes of Health (NIH) [R01DE16710, R01DE21464];
   International Association of Dental Research (IADR); Academy of
   Osseointegration (AO) Innovation in Implant Science Award; Ministry of
   Education, Science and Technology (MEST) in South Korea [2007-0054931];
   NIH [DK080344]
FX This project was supported by National Institutes of Health (NIH) grants
   R01DE16710 and R01DE21464, and the International Association of Dental
   Research (IADR) and the Academy of Osseointegration (AO) Innovation in
   Implant Science Award (to J.C.); Ministry of Education, Science and
   Technology (MEST) grant 2007-0054931 in South Korea (to S. H. K.); NIH
   grant DK080344 (to L. Q. D.). The funders had no role in study design,
   data collection and analysis, decision to publish, or preparation of the
   manuscript.
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NR 47
TC 33
Z9 37
U1 2
U2 15
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAY 16
PY 2014
VL 9
IS 5
AR e97824
DI 10.1371/journal.pone.0097824
PG 10
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA AM1NZ
UT WOS:000339614800072
PM 24836538
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Di Renzo, L
   Carraro, A
   Valente, R
   Iacopino, L
   Colica, C
   De Lorenzo, A
AF Di Renzo, Laura
   Carraro, Alberto
   Valente, Roberto
   Iacopino, Leonardo
   Colica, Carmen
   De Lorenzo, Antonino
TI Intake of Red Wine in Different Meals Modulates Oxidized LDL Level,
   Oxidative and Inflammatory Gene Expression in Healthy People: A
   Randomized Crossover Trial
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Article
ID LOW-DENSITY-LIPOPROTEIN; CARDIOVASCULAR-DISEASE; ANTIOXIDANT STATUS;
   METABOLIC SYNDROME; STRESS; ATHEROSCLEROSIS; CONSUMPTION; RESVERATROL;
   PREVENTION; BIOMARKERS
AB Several studies have found that adherence to the Mediterranean Diet, including consumption of red wine, is associated with beneficial effects on oxidative and inflammatory conditions. We evaluate the outcome of consumption of a McDonald's Meal (McD) and a Mediterranean Meal (MM), with and without the additive effect of red wine, in order to ascertain whether the addition of the latter has a positive impact on oxidized (ox-) LDL and on expression of oxidative and inflammatory genes. A total of 24 subjects were analyzed for ox-LDL, CAT, GPX1, SOD2, SIRT2, and CCL5 gene expression levels, before and after consumption of the 4 different meal combinations with washout intervals between each meal. When red wine is associated with McD or MM, values of ox-LDL are lowered (P < 0.05) and expression of antioxidant genes is increased, while CCL5 expression is decreased (P < 0.05). SIRT2 expression after MM and fasting with red wine is significantly correlated with downregulation of CCL5 and upregulation of CAT (P < 0.001). GPX1 increased significantly in the comparison between baseline and all conditions with red wine. We highlighted for the first time the positive effect of red wine intake combined with different but widely consumed meal types on ox-LDL and gene expression. Trial Registration. This trial is registered with ClinicalTrials gov NCT01890070.
C1 [Di Renzo, Laura; Carraro, Alberto; Valente, Roberto; Iacopino, Leonardo; De Lorenzo, Antonino] Univ Roma Tor Vergata, Dept Biomed & Prevent, Sect Clin Nutr & Nutrigen, I-00136 Rome, Italy.
   [Colica, Carmen] Magna Graecia Univ Catanzaro, Dept Pharmacol, ISN UOS Pharmacol, CNR, I-88021 Roccelletta Di Borgia, Catanzaro, Italy.
   [De Lorenzo, Antonino] Natl Inst Mediterranean Diet & Nutrigen INDiM, I-87032 Amantea, Italy.
C3 University of Rome Tor Vergata; Magna Graecia University of Catanzaro;
   Consiglio Nazionale delle Ricerche (CNR); Istituto di Scienze
   Neurologiche (ISN-CNR)
RP Di Renzo, L (corresponding author), Univ Roma Tor Vergata, Dept Biomed & Prevent, Sect Clin Nutr & Nutrigen, Via Montpellier 1, I-00136 Rome, Italy.
EM laura.di.renzo@uniroma2.it
RI Colica, Carmela/AAY-4131-2020; Di Renzo, Laura/ACB-2003-2022; Carraro,
   Alberto/JMP-2888-2023
OI Iacopino, Leonardo/0000-0002-1367-0682; De Lorenzo,
   Antonino/0000-0001-6524-4493; di renzo, laura/0000-0001-8875-6723
FU Ministry of Agriculture, Food and Forestry [DM 18829/7818/2009]
FX Laura Di Renzo designed the research and wrote the paper; Alberto
   Carraro, Roberto Valente, and Leonardo Iacopino conducted the research;
   Roberto Valente analyzed the data; Antonino De Lorenzo had primary
   responsibility for the final content. All authors read and approved the
   final paper. The authors would like to thank Francesca Sarlo, Daniela
   Minella, Guido Rillo, Anna Anzidei, Elaine Tyndall, and Nicoletta Del
   Duca for their contribution to the study. The authors have no financial
   or personal interests in any organization sponsoring the research at the
   time the research was conducted. This study was supported by Grants from
   the Ministry of Agriculture, Food and Forestry (DM 18829/7818/2009).
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NR 62
TC 38
Z9 42
U1 0
U2 6
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PY 2014
VL 2014
AR 681318
DI 10.1155/2014/681318
PG 9
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA AG9KO
UT WOS:000335738300001
PM 24876915
OA Green Submitted, hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Cocks, M
   Shepherd, SO
   Shaw, CS
   Achten, J
   Costa, ML
   Wagenmakers, AJM
AF Cocks, Matthew
   Shepherd, Sam O.
   Shaw, Christopher S.
   Achten, Juul
   Costa, Matthew L.
   Wagenmakers, Anton J. M.
TI Immunofluorescence Microscopy to Assess Enzymes Controlling Nitric Oxide
   Availability and Microvascular Blood Flow in Muscle
SO MICROCIRCULATION
LA English
DT Article
DE eNOS; NAD(P)H oxidase; muscle microvascular endothelial function;
   immunofluorescence microscopy
ID ENDOTHELIAL OXIDATIVE STRESS; SKELETAL-MUSCLE; INSULIN-RESISTANCE;
   METABOLIC SYNDROME; GLUCOSE-UPTAKE; EXERCISE; RECRUITMENT; PERFUSION;
   OBESITY; HUMANS
AB Objective: The net production of NO by the muscle microvascular endothelium is a key regulator of muscle microvascular blood flow. Here, we describe the development of a method to quantify the protein content and phosphorylation of endothelial NO synthase (eNOS content and eNOS ser1177 phosphorylation) and NAD(P)H oxidase expression. Methods: Human muscle cryosections were stained using antibodies targeting eNOS, p-eNOS ser1177 and NOX2 in combination with markers of the endothelium and the sarcolemma. Quantitation was achieved by analyzing fluorescence intensity within the area stained positive for the microvascular endothelium. Analysis was performed in duplicate and repeated five times to investigate CV. In addition, eight healthy males (age 21 +/- 1 year, BMI 24.4 +/- 1.0 kg/m2) completed one hour of cycling exercise at similar to 65%VO2max. Muscle biopsies were taken from the m. vastus lateralis before and immediately after exercise and analyzed using the new methods. Results: The CV of all methods was between 6.5 and 9.5%. Acute exercise increased eNOS serine1177 phosphorylation (fold change 1.29 +/- 0.05, p < 0.05). Conclusions: These novel methodologies will allow direct investigations of the molecular mechanisms underpinning the microvascular responses to insulin and exercise, the impairments that occur in sedentary, obese and elderly individuals and the effect of lifestyle interventions.
C1 [Cocks, Matthew; Shepherd, Sam O.; Shaw, Christopher S.; Wagenmakers, Anton J. M.] Univ Birmingham, Sch Sport & Exercise Sci, Exercise Metab Res Grp, Birmingham B15 2TT, W Midlands, England.
   [Achten, Juul; Costa, Matthew L.] Univ Warwick, Warwick Med Sch, Div Hlth Sci, Coventry CV4 7AL, W Midlands, England.
C3 University of Birmingham; University of Warwick
RP Wagenmakers, AJM (corresponding author), Univ Birmingham, Sch Sport & Exercise Sci, Exercise Metab Res Grp, Birmingham B15 2TT, W Midlands, England.
EM a.wagenmakers@bham.ac.uk
RI Cooper, Matthew/J-4420-2014; Achten, Juul/KUD-8515-2024; Cocks,
   Matthew/AAL-2811-2021; Wagenmakers, Anton/H-7625-2014
OI Shaw, Christopher/0000-0003-1499-0220; Costa,
   Matthew/0000-0003-3644-1388; Cocks, Matthew/0000-0003-1671-8714;
   Wagenmakers, Anton/0000-0003-1916-3822; Achten, Juul/0000-0002-8857-5743
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NR 35
TC 14
Z9 16
U1 0
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1073-9688
EI 1549-8719
J9 MICROCIRCULATION
JI Microcirculation
PD OCT
PY 2012
VL 19
IS 7
BP 642
EP 651
DI 10.1111/j.1549-8719.2012.00199.x
PG 10
WC Hematology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Hematology; Cardiovascular System & Cardiology
GA 019RJ
UT WOS:000309756700007
PM 22642427
DA 2025-06-11
ER

PT J
AU Deevska, GM
   Nikolova-Karakashian, MN
AF Deevska, Gergana M.
   Nikolova-Karakashian, Mariana N.
TI The twists and turns of sphingolipid pathway in glucose regulation
SO BIOCHIMIE
LA English
DT Review
DE Ceramide; Liver; Triacylglycerols; Serine palmitoyltransferase; Acid
   sphingomyelinase
ID SKELETAL-MUSCLE CELLS; KINASE-C-ZETA; INDUCED INSULIN-RESISTANCE;
   SATURATED FATTY-ACIDS; SERINE PALMITOYLTRANSFERASE ACTIVITY; CERAMIDE
   SYNTHESIS; HEPATIC STEATOSIS; PKC-ZETA; POTENTIAL MECHANISM; METABOLIC
   SYNDROME
AB Palmitic acid is a saturated fat found in foods that lead to obesity, cardiovascular disease, and Type II diabetes. It is linked to the development of resistance to insulin stimulation in muscle, liver and other organs involved in glucose metabolism, which, in turn, underlines the onset of Type II diabetes. The cellular and molecular mechanisms of this insulin resistance are complex and not completely understood. This article is focused on the role of palmitic acid as a precursor in the synthesis of sphingolipids, a class of lipid molecules that participate in cellular stress response. Recent evidence had indicated that increased dietary supply of palmitate can stimulate the rate of sphingolipid synthesis in "lean" tissues and generate excessive amounts of sphingolipid metabolites that have a negative effect on the insulin signaling cascade. Many experimental results point to the existence of a causative link between sphingolipid synthesis, insulin response, and hyperglycemia. It is not yet clear, however whether ceramides or glycosphingolipids are involved as both have been implicated to be inhibitors of the insulin signaling cascade. Evidence for a coordinated regulation of sphingolipid and tri/diacylglycerol metabolism complicates further the delineation of a single mechanism of sphingolipid effect on glucose homeostasis. (C) 2010 Elsevier Masson SAS. All rights reserved.
C1 [Nikolova-Karakashian, Mariana N.] Univ Kentucky, Coll Med, AB Chandler Med Ctr, Dept Physiol, Lexington, KY 40536 USA.
C3 University of Kentucky
RP Nikolova-Karakashian, MN (corresponding author), Univ Kentucky, Coll Med, AB Chandler Med Ctr, Dept Physiol, 800 Rose St, Lexington, KY 40536 USA.
EM mnikolo@uky.edu
OI Deevska, Gergana/0000-0002-1573-3026
FU  [AG026711];  [AG 019223]
FX This work was supported in parts by grants AG026711 and AG 019223
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NR 69
TC 21
Z9 24
U1 3
U2 20
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI PARIS
PA 23 RUE LINOIS, 75724 PARIS, FRANCE
SN 0300-9084
EI 1638-6183
J9 BIOCHIMIE
JI Biochimie
PD JAN
PY 2011
VL 93
IS 1
SI SI
BP 32
EP 38
DI 10.1016/j.biochi.2010.05.016
PG 7
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 710TG
UT WOS:000286539300007
PM 20561942
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Tegegne, BA
   Adugna, A
   Yenet, A
   Belay, WY
   Yibeltal, Y
   Dagne, A
   Teffera, ZH
   Amare, GA
   Abebaw, D
   Tewabe, H
   Abebe, RB
   Zeleke, TK
AF Tegegne, Bantayehu Addis
   Adugna, Adane
   Yenet, Aderaw
   Belay, Wubetu Yihunie
   Yibeltal, Yared
   Dagne, Abebe
   Teffera, Zigale Hibstu
   Amare, Gashaw Azanaw
   Abebaw, Desalegn
   Tewabe, Haymanot
   Abebe, Rahel Belete
   Zeleke, Tirsit Ketsela
TI A critical review on diabetes mellitus type 1 and type 2 management
   approaches: from lifestyle modification to current and novel targets and
   therapeutic agents
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Review
DE diabetes mellitus; lifestyle modification; current anti-diabetics; novel
   drugs and targets; probiotics; phtomedicines
ID GLYCEMIC CONTROL; METABOLIC SYNDROME; OXIDATIVE STRESS; GABAERGIC
   SYSTEM; INSULIN; INHIBITORS; PATHOGENESIS; ASSOCIATION; MECHANISMS;
   OBESITY
AB Diabetes mellitus (DM) has emerged as an international health epidemic due to its rapid rise in prevalence. Consequently, scientists and or researchers will continue to find novel, safe, effective, and affordable anti-diabetic medications. The goal of this review is to provide a thorough overview of the role that lifestyle changes play in managing diabetes, as well as the standard medications that are currently being used to treat the condition and the most recent advancements in the development of novel medical treatments that may be used as future interventions for the disease. A literature search was conducted using research databases such as PubMed, Web of Science, Scopus, ScienceDirect, Wiley Online Library, Google Scholar, etc. Data were then abstracted from these publications using words or Phrases like "pathophysiology of diabetes", "Signe and symptoms of diabetes", "types of diabetes", "major risk factors and complication of diabetes", "diagnosis of diabetes", "lifestyle modification for diabetes", "current antidiabetic agents", and "novel drugs and targets for diabetes management" that were published in English and had a strong scientific foundation. Special emphasis was given to the importance of lifestyle modification, as well as current, novel, and emerging/promising drugs and targets helpful for the management of both T1DM and T2DM.
C1 [Tegegne, Bantayehu Addis; Yenet, Aderaw; Belay, Wubetu Yihunie; Yibeltal, Yared; Dagne, Abebe; Zeleke, Tirsit Ketsela] Debre Markos Univ, Coll Med & Hlth Sci, Dept Pharm, Debre Markos, Ethiopia.
   [Adugna, Adane; Teffera, Zigale Hibstu; Amare, Gashaw Azanaw; Abebaw, Desalegn; Tewabe, Haymanot] Debre Markos Univ, Coll Med & Hlth Sci, Dept Med Lab Sci, Debre Markos, Ethiopia.
   [Abebe, Rahel Belete] Univ Gondar, Coll Med & Hlth Sci, Sch Pharm, Dept Clin Pharm, Gondar, Ethiopia.
C3 University of Gondar
RP Tegegne, BA (corresponding author), Debre Markos Univ, Coll Med & Hlth Sci, Dept Pharm, Debre Markos, Ethiopia.
EM bantayehuaddis.90@gmail.com
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NR 141
TC 2
Z9 2
U1 4
U2 5
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD OCT 18
PY 2024
VL 15
AR 1440456
DI 10.3389/fendo.2024.1440456
PG 20
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA K6X6L
UT WOS:001345290900001
PM 39493778
OA gold
DA 2025-06-11
ER

PT J
AU Moon, H
   Ha, JH
   Lee, J
   Jang, H
   Kwon, D
   Cho, M
   Kang, D
   Kim, I
   Kim, M
AF Moon, Heewon
   Ha, Jung-Heun
   Lee, Jisu
   Jang, Hyunsoo
   Kwon, Dain
   Cho, Minji
   Kang, Dahyun
   Kim, Inyong
   Kim, Misook
TI The Effect of Fermented Momordica charantia with Leuconostoc
   mesenteroides MKSR on Metabolic Complications Induced by High-Fat
   High-Cholesterol Diet in C57BL/6 Mice
SO FERMENTATION-BASEL
LA English
DT Article
DE Momordica charantia; high-fat high-cholesterol diet; metabolic syndrome;
   Leuconostoc
ID GUT MICROBIOTA; INSULIN-RESISTANCE; OBESITY; L.; EXTRACTION; MECHANISM;
   STRESS; TYPE-1; JUICE
AB This study aimed to investigate the beneficial effects of Momordica charantia (MC) extract and MC fermented with Leuconostoc mesenteroides MKSR (FMC) on high-fat and high-cholesterol diet-induced metabolic complications. Male C57BL/6 mice were divided into six groups: normal diet (ND), high-fat and high-cholesterol diet (HFCD), HFCD with 1% MC extract (HFCD + 1M), HFCD with 4% MC extract (HFCD + 4M), HFCD with 1% fermented MC (HFCD + 1F), and HFCD with 4% fermented MC (HFCD + 4F). After 12 weeks of dietary intervention, the consumption of MC fermented with L. mesenteroides MKSR resulted in significant decreases in white adipose tissue weights (epididymal adipose tissue and retroperitoneal adipose tissue), serum alanine aminotransferase activity, and hepatic triglyceride levels. FMC also lowered total hepatic cholesterol content, improved glucose clearance during the oral glucose tolerance and insulin tolerance tests, and increased fecal cholesterol efflux from the enterohepatic circulation. Furthermore, the FMC notably increased hepatic mRNA expressions, which may indicate a compensatory mechanism against induced cholesterol efflux. Moreover, FMC induced both adipogenic (sterol regulatory element-binding protein 1c) and lipolytic (lipoprotein lipase, peroxisome proliferator-activated receptor alpha, and adiponectin) mRNA expressions. These findings suggest that fermentation with the probiotic L. mesenteroides MKSR enhances the beneficial effects of MC, preventing metabolic complications associated with a high-fat diet.
C1 [Moon, Heewon; Ha, Jung-Heun; Lee, Jisu; Jang, Hyunsoo; Kwon, Dain; Cho, Minji; Kang, Dahyun; Kim, Misook] Dankook Univ, Dept Food Sci & Nutr, Cheonan 31116, South Korea.
   [Ha, Jung-Heun; Kim, Misook] Dankook Univ, Res Ctr Industrializat Nat Neutralizat, Yongin 16890, South Korea.
   [Kim, Inyong] Sunchon Univ, Dept Food & Nutr, Sunchon 57922, South Korea.
C3 Dankook University; Dankook University; Sunchon National University
RP Kim, M (corresponding author), Dankook Univ, Dept Food Sci & Nutr, Cheonan 31116, South Korea.; Kim, M (corresponding author), Dankook Univ, Res Ctr Industrializat Nat Neutralizat, Yongin 16890, South Korea.; Kim, I (corresponding author), Sunchon Univ, Dept Food & Nutr, Sunchon 57922, South Korea.
EM hw1356@naver.com; ha@dankook.ac.kr; dlwltn970811@naver.com;
   jjang21119@naver.com; ekdls5080@daum.net; bluepill0103@naver.com;
   ekgu0420@naver.com; ikim@scnu.ac.kr; mkim5@dankook.ac.kr
OI Kim, Misook/0000-0002-9091-8776; HA, JUNG-HEUN/0000-0001-5282-531X
FU National Research Foundation of Korea [2020R1I1A3072127]; Ministry of
   Small and Medium-sized Enterprises and Startups of Korea [S3093086]
FX This research was funded by the National Research Foundation of Korea,
   2020R1I1A3072127, and Ministry of Small and Medium-sized Enterprises and
   Startups of Korea: S3093086.
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NR 91
TC 4
Z9 4
U1 1
U2 8
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2311-5637
J9 FERMENTATION-BASEL
JI FERMENTATION
PD AUG
PY 2023
VL 9
IS 8
AR 718
DI 10.3390/fermentation9080718
PG 19
WC Biotechnology & Applied Microbiology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Food Science & Technology
GA Q4IU7
UT WOS:001057179100001
OA gold
DA 2025-06-11
ER

PT J
AU Zheng, H
   Ji, H
   Fan, K
   Xu, HY
   Huang, YL
   Zheng, YF
   Xu, QQ
   Li, C
   Zhao, LC
   Li, YP
   Gao, HC
AF Zheng, Hong
   Ji, Hui
   Fan, Kai
   Xu, Hangying
   Huang, Yinli
   Zheng, Yafei
   Xu, Qingqing
   Li, Chen
   Zhao, Liangcai
   Li, Yuping
   Gao, Hongchang
TI Targeting Gut Microbiota and Host Metabolism with Dendrobium
   officinale Dietary Fiber to Prevent Obesity and Improve Glucose
   Homeostasis in Diet-Induced Obese Mice
SO MOLECULAR NUTRITION & FOOD RESEARCH
LA English
DT Article
DE anti-obesity; dietary fibers; gut microbiota; inflammation; metabolic
   health
ID INSULIN-RESISTANCE; FAT ACCUMULATION; INFLAMMATION; POLYSACCHARIDES;
   PROTECTS; CHOLINE; ADULTS; TISSUE; LIVER
AB Scope Obesity is becoming a major public health problem due to excess dietary fat intake. Dendrobium officinale (D. officinale) is a medicine food homology plant and exerts multiple health-promoting effects. However, its antiobesity effects and the potential mechanisms remain unclear. Methods and results High-fat diet (HFD)-fed mice are administered D. officinale dietary fiber (DODF) daily by gavage for 11 weeks. The results show that treatment with DODF alleviates obesity, liver steatosis, inflammation, and oxidant stress in HFD-induced obese mice. Improved glucose homeostasis in obese mice after DODF treatment is achieved by enhancing insulin pathway and hepatic glycogen synthesis. DODF restructures the gut microbiota in obese mice by decreasing the relative abundance of Bilophila and increasing the relative abundances of Akkermansia, Bifidobacterium, and Muribaculum. Also, DODF reshapes the metabolic phenotype of obese mice as indicated by up-regulating energy metabolism, increasing acetate and taurine, and reducing serum low density/very low density lipoproteins (LDL/VLDL). These beneficial effects are partly transferred by FMT, implying the gut microbiota as a target for the protective effect of DODF on obesity-related symptoms. Conclusion The results suggest that DODF can be used as a novel prebiotics to maintain the gut microbial homeostasis and improve metabolic health, preventing obesity and related metabolic syndrome.
C1 [Zheng, Hong; Ji, Hui; Fan, Kai; Xu, Hangying; Zheng, Yafei; Xu, Qingqing; Li, Chen; Zhao, Liangcai; Gao, Hongchang] Wenzhou Med Univ, Sch Pharmaceut Sci, Inst Metabon & Med NMR, Wenzhou 325035, Peoples R China.
   [Zheng, Hong; Huang, Yinli] Wenzhou Med Univ, Dept Endocrinol, Pingyang Affiliated Hosp, Wenzhou 325400, Peoples R China.
   [Li, Yuping; Gao, Hongchang] Wenzhou Med Univ, Dept Pulm & Crit Care Med, Affiliated Hosp 1, Wenzhou 325000, Zhejiang, Peoples R China.
C3 Wenzhou Medical University; Wenzhou Medical University; Wenzhou Medical
   University
RP Zheng, H; Gao, HC (corresponding author), Wenzhou Med Univ, Sch Pharmaceut Sci, Inst Metabon & Med NMR, Wenzhou 325035, Peoples R China.; Zheng, H (corresponding author), Wenzhou Med Univ, Dept Endocrinol, Pingyang Affiliated Hosp, Wenzhou 325400, Peoples R China.; Gao, HC (corresponding author), Wenzhou Med Univ, Dept Pulm & Crit Care Med, Affiliated Hosp 1, Wenzhou 325000, Zhejiang, Peoples R China.
EM 123zhenghong321@163.com; gaohc27@wmu.edu.cn
RI Zheng, Hong/ABG-7392-2021
OI Zheng, Hong/0000-0002-3401-721X
FU Scientific Research Center of Wenzhou Medical University; National
   Natural Science Foundation of China [22074106, 81771386, 21575105];
   Medical and Health Science and Technology Project of Zhejiang Province
   [2022KY1215]
FX The Scientific Research Center of Wenzhou Medical University is
   acknowledged for technical services. This study was supported by the
   National Natural Science Foundation of China (No.: 22074106, 81771386
   and 21575105) and the Medical and Health Science and Technology Project
   of Zhejiang Province (No.: 2022KY1215).
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NR 69
TC 25
Z9 26
U1 11
U2 109
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1613-4125
EI 1613-4133
J9 MOL NUTR FOOD RES
JI Mol. Nutr. Food Res.
PD MAY
PY 2022
VL 66
IS 10
AR 2100772
DI 10.1002/mnfr.202100772
EA MAR 2022
PG 15
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA 1I4CV
UT WOS:000769480500001
PM 35225418
DA 2025-06-11
ER

PT J
AU Gorabi, AM
   Abbasifard, M
   Imani, D
   Aslani, S
   Razi, B
   Alizadeh, S
   Bagheri-Hosseinabadi, Z
   Sathyapalan, T
   Sahebkar, A
AF Gorabi, Armita Mahdavi
   Abbasifard, Mitra
   Imani, Danyal
   Aslani, Saeed
   Razi, Bahman
   Alizadeh, Shahab
   Bagheri-Hosseinabadi, Zahra
   Sathyapalan, Thozhukat
   Sahebkar, Amirhossein
TI Effect of curcumin on C-reactive protein as a biomarker of systemic
   inflammation: An updated meta-analysis of randomized controlled trials
SO PHYTOTHERAPY RESEARCH
LA English
DT Review
DE CRP; curcumin; hs-CRP; inflammation
ID RHEUMATOID-ARTHRITIS PATIENTS; DOUBLE-BLIND; DIAGNOSTIC INDICATORS;
   METABOLIC SYNDROME; IMPROVES SYMPTOMS; OXIDATIVE STRESS; IN-VITRO;
   KAPPA-B; SUPPLEMENTATION; DISEASE
AB It has been suggested that curcumin is a potential agent for lowering the levels of C-reactive protein (CRP) and high-sensitivity CRP (hs-CRP), as markers of inflammation. In the current meta-analysis, we attempted to clarify the efficacy of curcumin supplementation in lowering the concentrations of CRP and hs-CRP in patients with autoinflammatory conditions. Nine studies were found evaluating the effect of curcumin on CRP levels, while 23 studies were identified for hs-CRP. CRP concentration was decreased significantly compared to the placebo (WMD = -3.67 mg/L, 95% CI = -6.96 to -0.38, p = 0.02). There was a significant effect of curcumin at dose <= 1,000 mg/day on the CRP concentration. CRP concentration significantly decreased after >10-week intervention compared with placebo.hs-CRP concentration in the intervention group was significantly lower than that of placebo group. A significant effect of curcumin consumption was detected on the serum level of hs-CRP in studies with prescribing <= 1,000 mg/day, and those with <= 10-week duration of intervention. Curcumin consumption resulted in a reduction of hs-CRP in a non-linear fashion with stronger effects with less than 2000 mg curcumin per day. Curcumin seems to be beneficial in decreasing the hs-CRP and CRP levels in proinflammatory settings.
C1 [Gorabi, Armita Mahdavi] Univ Tehran Med Sci, Res Ctr Adv Technol Cardiovasc Med, Tehran Heart Ctr, Tehran, Iran.
   [Abbasifard, Mitra] Rafsanjan Univ Med Sci, Ali Ibn Abi Talib Hosp, Dept Internal Med, Rafsanjan, Iran.
   [Abbasifard, Mitra; Bagheri-Hosseinabadi, Zahra] Res Inst Basic Med Sci, Mol Med Res Ctr, Rafsanjan, Iran.
   [Imani, Danyal] Univ Tehran Med Sci, Sch Publ Hlth, Dept Immunol, Tehran, Iran.
   [Aslani, Saeed] Univ Tehran Med Sci, Sch Med, Dept Immunol, Tehran, Iran.
   [Razi, Bahman] Tarbiat Modares Univ, Sch Med, Dept Hematol & Blood Transfus, North Kargar Ave, Tehran 14117, Iran.
   [Alizadeh, Shahab] Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Cellular & Mol Nutr, Tehran, Iran.
   [Bagheri-Hosseinabadi, Zahra] Rafsanjan Univ Med Sci, Fac Med, Dept Clin Biochem, Rafsanjan, Iran.
   [Sathyapalan, Thozhukat] Univ Hull, Acad Diabet Endocrinol & Metab, Hull York Med Sch, Kingston Upon Hull, N Humberside, England.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Biotechnol Res Ctr, Pharmaceut Technol Inst, Mashhad, Razavi Khorasan, Iran.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Appl Biomed Res Ctr, Mashhad, Razavi Khorasan, Iran.
   [Sahebkar, Amirhossein] Univ Western Australia, Sch Med, Perth, WA, Australia.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Sch Pharm, Mashhad, Razavi Khorasan, Iran.
C3 Tehran University of Medical Sciences; Tehran University of Medical
   Sciences; Tehran University of Medical Sciences; Tarbiat Modares
   University; Tehran University of Medical Sciences; University of Hull;
   University of York - UK; Mashhad University of Medical Sciences; Mashhad
   University of Medical Sciences; University of Western Australia; Mashhad
   University of Medical Sciences
RP Razi, B (corresponding author), Tarbiat Modares Univ, Sch Med, Dept Hematol & Blood Transfus, North Kargar Ave, Tehran 14117, Iran.; Sahebkar, A (corresponding author), Mashhad Univ Med Sci, Sch Med, Dept Med Biotechnol, POB 91779-48564, Mashhad, Razavi Khorasan, Iran.
EM b.razi@modares.ac.ir; sahebkara@mums.ac.ir
RI Aslani, Saeed/AAV-6835-2020; Abbasifard, mitra/I-1595-2017; Razi,
   Bahman/HCI-8979-2022; Sathyapalan, Thozhukat/J-5212-2012; Sahebkar,
   Amirhossein/B-5124-2018; bagheri, zahra/O-5273-2018
OI Sathyapalan, Thozhukat/0000-0003-3544-2231
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NR 70
TC 33
Z9 34
U1 0
U2 10
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0951-418X
EI 1099-1573
J9 PHYTOTHER RES
JI Phytother. Res.
PD JAN
PY 2022
VL 36
IS 1
BP 85
EP 97
DI 10.1002/ptr.7284
EA SEP 2021
PG 13
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA YJ6VJ
UT WOS:000700974700001
PM 34586711
DA 2025-06-11
ER

PT J
AU Moreno-Pérez, B
   Benito, E
   Civera, M
   Alabadi, B
   Martinez-Hervas, S
   Peiro, M
   González-Navarro, H
   Piqueras, L
   Sanz, MJ
   Ascaso, JF
   Real, JT
AF Moreno-Perez, Beatriz
   Benito, Esther
   Civera, Miguel
   Alabadi, Blanca
   Martinez-Hervas, Sergio
   Peiro, Marta
   Gonzalez-Navarro, Herminia
   Piqueras, Laura
   Sanz, Maria Jesus
   Ascaso, Juan F.
   Real, Jose T.
TI Postprandial triglyceridaemia is modulated by insulin resistance but not
   by grade of obesity in abdominal and morbid obese subjects
SO INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
LA English
DT Article
ID METABOLIC SYNDROME; ENDOTHELIAL FUNCTION; OXIDATIVE STRESS; OLIVE OIL;
   LIPEMIA; INFLAMMATION; GENDER; RISK; ACID; MEN
AB Background Obesity is associated with high cardiovascular risk. Postprandial lipidaemia has been associated with cardiovascular disease risk. Our aim was to identify whether anthropometric parameters, insulin resistance (IR) and/or fasting plasma triglycerides may determine postprandial changes in lipoprotein concentrations in abdominal and morbid obese subjects.
   Methods We have studied 20 non-diabetic, normolipidaemic subjects with abdominal obesity, 20 morbid obese subjects and 20 healthy individuals, that have similar age and gender. In all of them a standardised oral fat load test (OFLT) with unsaturated fat was performed.
   Results During the OFLT, the postprandial triglycerides response was significantly higher in subjects with abdominal obesity compared with morbid obese subjects (4 hours triglycerides pick value and AUC of triglycerides). Both obese groups showed significantly higher postprandial triglycerides response compared with healthy subjects. Dividing the obesity group according to the presence of IR, we found that IR was an important factor related with postprandial lipaemia but not BMI or waist circumference. In addition, postprandial glycaemia and insulinaemia significantly decreased in all studied subjects, being the highest decrease in morbid obese subjects and in subjects with IR. Postprandial triglyceridaemia significantly correlated with IR parameters and not with anthropometric parameters in AO and MO subjects.
   Conclusion In subjects with AO and MO, postprandial triglycerides values are higher than healthy individuals and independently predicted by fasting IR parameters. Furthermore, unsaturated fat improved IR state.
C1 [Moreno-Perez, Beatriz; Civera, Miguel; Alabadi, Blanca; Martinez-Hervas, Sergio; Ascaso, Juan F.; Real, Jose T.] Hosp Clin Univ Valencia, Serv Endocrinol & Nutr, Avda Blasco Ibanez 17, Valencia 46010, Spain.
   [Moreno-Perez, Beatriz; Benito, Esther; Civera, Miguel; Alabadi, Blanca; Martinez-Hervas, Sergio; Peiro, Marta; Gonzalez-Navarro, Herminia; Piqueras, Laura; Sanz, Maria Jesus; Ascaso, Juan F.; Real, Jose T.] Hosp Clin Univ Valencia INCLIVA, Inst Hlth Res, Valencia, Spain.
   [Benito, Esther; Martinez-Hervas, Sergio; Piqueras, Laura; Real, Jose T.] CIBER Diabet & Enfermedades Metab Asociadas CIBER, Madrid, Spain.
   [Civera, Miguel; Martinez-Hervas, Sergio; Peiro, Marta; Gonzalez-Navarro, Herminia; Ascaso, Juan F.; Real, Jose T.] Univ Valencia, Dept Med, Valencia, Spain.
   [Gonzalez-Navarro, Herminia] Univ Valencia, Dept Didact Expt & Social Sci, Valencia, Spain.
   [Piqueras, Laura; Sanz, Maria Jesus] Univ Valencia, Dept Pharmacol, Valencia, Spain.
C3 CIBER - Centro de Investigacion Biomedica en Red; CIBERES; University of
   Valencia; University of Valencia; University of Valencia
RP Martinez-Hervas, S (corresponding author), Hosp Clin Univ Valencia, Serv Endocrinol & Nutr, Avda Blasco Ibanez 17, Valencia 46010, Spain.
EM sergio.martinez@uv.es
RI Jordán, María/T-1175-2019; PIQUERAS, LAURA/LXW-1265-2024; Martinez
   Hervas, Sergio/K-2829-2014
OI PIQUERAS, LAURA/0000-0001-8010-5168; Alabadi,
   Blanca/0000-0001-5129-6954; Gonzalez-Navarro,
   Herminia/0000-0001-6883-3808; Martinez Hervas,
   Sergio/0000-0002-6775-2034; Sanz, Maria Jesus/0000-0002-8885-294X
FU Fondo de Investigaciones Sanitarias [FIS PI12/01978]; CIBERDEM (ISCIII);
   Instituto de Salud Carlos III [JR18/00051, CP16/00013]; European
   Regional Development Fund (FEDER) [JR18/00051, CP16/00013]
FX supported by grants from Fondo de Investigaciones Sanitarias to Jose T.
   Real (FIS PI12/01978) and CIBERDEM (ISCIII). CIBER de Diabetes and
   Enfermedades Metabolicas Asociadas (CIBERDEM) is an Instituto de Salud
   Carlos III initiative. Sergio Martinez-Hervas is an investigator in the
   'Juan Rodes' program (JR18/00051) and Herminia Gonzalez Navarro was an
   investigator in the Miguel Servet 2 program (CP16/00013) both financed
   by the Instituto de Salud Carlos III and the European Regional
   Development Fund (FEDER). Herminia Gonzalez Navarro is also a GenT
   Investigator of Excellence (CDEI-04-20-B)
CR [Anonymous], 2015, OB OV
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NR 28
TC 3
Z9 3
U1 1
U2 8
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1368-5031
EI 1742-1241
J9 INT J CLIN PRACT
JI Int. J. Clin. Pract.
PD APR
PY 2021
VL 75
IS 4
AR e13776
DI 10.1111/ijcp.13776
EA NOV 2020
PG 9
WC Medicine, General & Internal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Pharmacology & Pharmacy
GA RC8GK
UT WOS:000587565800001
PM 33089594
OA gold
DA 2025-06-11
ER

PT J
AU Yang, YC
   Schorpp, K
   Boen, C
   Johnson, M
   Harris, KM
AF Yang, Yang Claire
   Schorpp, Kristen
   Boen, Courtney
   Johnson, Moira
   Harris, Kathleen Mullan
TI Socioeconomic Status and Biological Risks for Health and Illness Across
   the Life Course
SO JOURNALS OF GERONTOLOGY SERIES B-PSYCHOLOGICAL SCIENCES AND SOCIAL
   SCIENCES
LA English
DT Article
DE Aging; Inflammation; Life course; Metabolic disorder; Physiological
   functioning; SES
ID METABOLIC SYNDROME; SOCIAL CONDITIONS; CHILDHOOD; INFLAMMATION;
   EDUCATION; STRESS; INCOME; MIDDLE; DIFFERENTIALS; EPIDEMIOLOGY
AB Objectives We assess the temporal properties and biosocial mechanisms underlying the associations between early-life socioeconomic status (SES) and later health. Using a life-course design spanning adolescence to older adulthood, we assess how early life and various dimensions of adult SES are associated with immune and metabolic function in different life stages and examine possible bio-behavioral and psychosocial mechanisms underlying these associations.
   Method Data for this study come from 3 national studies that collectively cover multiple stages of the life course (Add Health, MIDUS, and HRS). We estimated generalized linear models to examine the prospective associations between early-life SES, adult SES, and biomarkers of chronic inflammation and metabolic disorder assessed at follow-up. We further conducted formal tests of mediation to assess the role of adult SES in linking early SES to biological functions.
   Results We found that early-life SES exerted consistent protective effects for metabolic disorder across the life span, but waned with time for CRP. The protective effect of respondent education remained persistent for CRP but declined with age for metabolic disorder. Adult income and assets primarily protected respondents against physiological dysregulation in middle and old ages, but not in early adulthood.
   Discussion These findings are the first to elucidate the life-course patterns of SES that matter for underlying physiological functioning during the aging process to produce social gradients in health.
C1 [Yang, Yang Claire; Johnson, Moira; Harris, Kathleen Mullan] Univ N Carolina, Dept Sociol, Chapel Hill, NC 27516 USA.
   [Yang, Yang Claire] Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27516 USA.
   [Yang, Yang Claire; Johnson, Moira; Harris, Kathleen Mullan] Univ N Carolina, Carolina Populat Ctr, CB 8120,123 West Franklin St, Chapel Hill, NC 27516 USA.
   [Schorpp, Kristen] Roanoke Coll, Dept Sociol, Salem, VA 24153 USA.
   [Boen, Courtney] Univ Penn, Dept Sociol, Philadelphia, PA 19104 USA.
   [Boen, Courtney] Univ Penn, Populat Studies Ctr, Philadelphia, PA 19104 USA.
C3 University of North Carolina; University of North Carolina Chapel Hill;
   University of North Carolina; University of North Carolina Chapel Hill;
   University of North Carolina; University of North Carolina Chapel Hill;
   University of Pennsylvania; University of Pennsylvania
RP Yang, YC (corresponding author), Univ N Carolina, Carolina Populat Ctr, CB 8120,123 West Franklin St, Chapel Hill, NC 27516 USA.
EM yangy@unc.edu
FU National Institute of Aging [R01AG057800]; National Science Foundation
   [DGE-1144081]; Eunice Kennedy Shriver National Institute of Child Health
   and Human Development [P01HD31921, T32 HD007168]; Carolina Population
   Center, University of North Carolina at Chapel Hill [R24 HD050924];
   National Institute of Child Health and Human Development [P01HD31921]
FX This research was supported by the National Institute of Aging grant
   R01AG057800 (PI: Y. C. Yang; Co-I: K. M. Harris), National Science
   Foundation Graduate Research Fellowship grant (DGE-1144081 to M.
   Johnson), and by the Eunice Kennedy Shriver National Institute of Child
   Health and Human Development grant P01HD31921 (PI: K. M. Harris; Co-I:
   Y. C. Yang). We are grateful for training support from the National
   Institute of Child Health and Human Development (T32 HD007168) and for
   general research support (R24 HD050924) from the Carolina Population
   Center, University of North Carolina at Chapel Hill. This research uses
   data from Add Health, a program project directed by Kathleen Mullan
   Harris and designed by J. Richard Udry, Peter S. Bearman, and K. M.
   Harris at the University of North Carolina at Chapel Hill, and funded by
   grant P01HD31921 from National Institute of Child Health and Human
   Development with cooperative funding from 23 other federal agencies and
   foundations.
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NR 40
TC 42
Z9 48
U1 1
U2 23
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1079-5014
EI 1758-5368
J9 J GERONTOL B-PSYCHOL
JI J. Gerontol. Ser. B-Psychol. Sci. Soc. Sci.
PD MAR
PY 2020
VL 75
IS 3
BP 613
EP 624
DI 10.1093/geronb/gby108
PG 12
WC Geriatrics & Gerontology; Gerontology; Psychology; Psychology,
   Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Psychology
GA KS8CU
UT WOS:000518534200016
PM 30252104
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Hamzehzadeh, L
   Atkin, SL
   Majeed, M
   Butler, AE
   Sahebkar, A
AF Hamzehzadeh, Leila
   Atkin, Stephen L.
   Majeed, Muhammed
   Butler, Alexandra E.
   Sahebkar, Amirhossein
TI The versatile role of curcumin in cancer prevention and treatment: A
   focus on PI3K/AKT pathway
SO JOURNAL OF CELLULAR PHYSIOLOGY
LA English
DT Review
DE apoptosis; cancer; curcumin; malignancies; PI3K; AKT pathway
ID RANDOMIZED CONTROLLED-TRIAL; SYSTEMIC OXIDATIVE STRESS; TYPE-2
   DIABETES-MELLITUS; FATTY LIVER-DISEASE; CLINICAL-PRACTICE; PIPERINE
   COMBINATION; METABOLIC SYNDROME; ANTITUMOR-ACTIVITY; SIGNALING PATHWAY;
   MOLECULAR TARGETS
AB Despite significant advances in treatment modalities, millions of cancer-related deaths continue to occur annually, often as a consequence of developing resistance against the range of available chemotherapeutic drugs. Furthermore, available anti-cancer chemotherapeutic agents show limited efficacy, often have severe side effects, and are expensive. Thus, the discovery of pharmacological agents that do not have these disadvantages is necessary. Curcumin, a polyphenolic compound derived from turmeric (Curcumin longa L.), is one such agent that has been widely studied for its anti-inflammatory and/or anti-cancer effects. Curcumin exerts its anti-cancer effect by suppressing the initiation, progression, and metastasis of a variety of cancers and appears to inhibit carcinogenesis by affecting two main processes: angiogenesis and tumor growth. These anti-cancer effects are largely mediated via negative regulation of various transcription factors, growth factors, inflammatory cytokines, protein kinases, and other oncogenic molecules. The PI3K/AKT pathway is commonly activated in cancer initiation and progression. Considered to be the key signaling pathway, the phosphatidylinositol-3-kinase (PI3K)/protein kinase B (AKT) pathway therefore represents a key target for cancer therapeutics. In the current review, we focus upon curcumin's targeting of PI3K/AKT in different malignancies to effect inhibition of cancer development and progression.
C1 [Hamzehzadeh, Leila] Mashhad Univ Med Sci, Dept Med Genet, Fac Med, Mashhad, Iran.
   [Atkin, Stephen L.] Weill Cornell Med Qatar, Doha, Qatar.
   [Majeed, Muhammed] Sabinsa Corp, East Windsor, NJ USA.
   [Butler, Alexandra E.] Antidoping Lab Qatar, Life Sci Res Div, Doha, Qatar.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Neurogen Inflammat Res Ctr, Mashhad, Iran.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Biotechnol Res Ctr, Mashhad, Iran.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Sch Pharm, Mashhad, Iran.
C3 Mashhad University of Medical Sciences; Qatar Foundation (QF); Weill
   Cornell Medical College Qatar; Anti Doping Laboratory (Qatar); Mashhad
   University of Medical Sciences; Mashhad University of Medical Sciences;
   Mashhad University of Medical Sciences
RP Sahebkar, A (corresponding author), Mashhad Univ Med Sci, Sch Med, Dept Med Biotechnol, POB 9177948564, Mashhad, Iran.
EM sahebkara@mums.ac.ir
RI Sahebkar, Amirhossein/B-5124-2018; Atkin, stephen/ABE-7047-2020; Atkin,
   Stephen/D-7400-2014
OI Butler, Alexandra/0000-0002-5762-3917; Atkin,
   Stephen/0000-0002-5887-7257
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NR 96
TC 115
Z9 132
U1 0
U2 73
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0021-9541
EI 1097-4652
J9 J CELL PHYSIOL
JI J. Cell. Physiol.
PD OCT
PY 2018
VL 233
IS 10
BP 6530
EP 6537
DI 10.1002/jcp.26620
PG 8
WC Cell Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Physiology
GA GM7GX
UT WOS:000438352300019
PM 29693253
DA 2025-06-11
ER

PT J
AU Rodriguez-Rodriguez, R
   Jiménez-Altayo, F
   Alsina, L
   Onetti, Y
   de Alvarenga, JFR
   Claro, C
   Ogalla, E
   Casals, N
   Lamuela-Raventos, RM
AF Rodriguez-Rodriguez, Rosalia
   Jimenez-Altayo, Francesc
   Alsina, Laia
   Onetti, Yara
   Rinaldi de Alvarenga, Jose Fernando
   Claro, Carmen
   Ogalla, Elena
   Casals, Nuria
   Lamuela-Raventos, Rosa M.
TI Mediterranean tomato-based sofrito protects against vascular
   alterations in obese Zucker rats by preserving NO bioavailability
SO MOLECULAR NUTRITION & FOOD RESEARCH
LA English
DT Article
DE Mediterranean diet; Nitric oxide; Obesity; Sofrito; Vascular function
ID LINKED INSULIN-RESISTANCE; NITRO-OXIDATIVE STRESS; METABOLIC SYNDROME;
   DIETARY POLYPHENOLS; BLOOD-VESSELS; OLIVE OIL; OXIDE; LYCOPENE; RISK;
   INFLAMMATION
AB Scope: Softito, a key component of the Mediterranean diet, provides nutritional interest due to its high content in bioactive compounds from tomato and olive oil, and especially to the lipid matrix in which these compounds are found. In this study, the potential beneficial effects of dietary intake of sofrito on obesity-related vascular alterations were explored in obese Zucker rats.
   Methods and results: Obese and lean rats were fed a control diet supplemented or not with 2% w/w softito for 8 weeks. Vascular function was evaluated in aorta in organ baths. Dihydroethidium staining and immunofluorescence was used to determine aortic superoxide and peroxynitrite production, respectively. Despite food and caloric intake was higher in sofiito-fed obese rats, no differences were appreciated on body weight compared to control rats. Sofrito attenuated phenylephrine-induced vasoconstriction. This effect was associated with preservation of nitric oxide on vasoconstriction and normalization of serum nitric oxide metabolites, vascular inducible nitric oxide synthase and vascular superoxide and peroxynitrite levels.
   Conclusion: This is the first evidence of tomato-based sofrito protection against vascular alterations that could precede major cardiometabolic complications in obesity. These results contribute to explain the therapeutic properties of the Mediterranean diet in obesity-related disorders. Therefore, sofrito is an attractive dietary approach against vascular alterations in obesity.
C1 [Rodriguez-Rodriguez, Rosalia; Casals, Nuria] Univ Int Catalunya, Fac Med & Hlth Sci, Basic Sci Dept, Barcelona, Spain.
   [Jimenez-Altayo, Francesc; Alsina, Laia; Onetti, Yara] Univ Autonoma Barcelona, Fac Med, Inst Neurociencies, Dept Farmacol Terapeut & Toxicol, Bellaterra, Spain.
   [Claro, Carmen; Ogalla, Elena] Univ Seville, Fac Farm, Dept Farmacol, Seville, Spain.
   [Rinaldi de Alvarenga, Jose Fernando; Lamuela-Raventos, Rosa M.] Univ Barcelona, INSA UB Pharm, XaRTA, Nutr Food Sci Dept & Gastron, Barcelona, Spain.
   [Casals, Nuria; Lamuela-Raventos, Rosa M.] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr CIBEROBN, Madrid, Spain.
C3 Universitat Internacional de Catalunya (UIC); Autonomous University of
   Barcelona; University of Sevilla; University of Barcelona; CIBER -
   Centro de Investigacion Biomedica en Red; CIBEROBN; Instituto de Salud
   Carlos III
RP Rodriguez-Rodriguez, R (corresponding author), Univ Int Catalunya, Fac Med & Hlth Sci, Basic Sci Dept, Barcelona, Spain.
EM rrodriguez@uic.es
RI Raventos, Rosa/F-3986-2016; Alsina, Laia/GQI-3516-2022; Rinaldi de
   Alvarenga, Jose Fernando/C-5420-2019; Claro-Cala,
   Carmen-Maria/F-7886-2016; Casals, Nuria/L-3378-2014; Jimenez Altayo,
   Francesc/F-1245-2011
OI Rinaldi de Alvarenga, Jose Fernando/0000-0002-1137-1873; Claro-Cala,
   Carmen-Maria/0000-0001-9943-405X; Casals, Nuria/0000-0002-6719-4300;
   Jimenez Altayo, Francesc/0000-0002-9034-2041; Rodriguez-Rodriguez,
   Rosalia/0000-0002-6908-7197
FU Spanish Ministry of Economy and Competitiveness-CICYT
   [AGL2013-49083-C3-1-R, AGL2016-79113-R, SAF 2014-52223-C2-2-R];
   Generalitat de Catalunya [2014SGR773, 2014SGR574]; Fundacio La Marato de
   TV3 [87/C/2016]; Centro de Investigation Biomedica en Red de la
   Fisiopatologia de la Obesidad y Nutricion (CIBEROBN); Projectes de
   Recerca per a Investigadors Novells a la Universitat Internacional de
   Catalunya
FX The authors are grateful to Alberto Lopez Vivas for technical
   assistance. This study was supported by the Spanish Ministry of Economy
   and Competitiveness-CICYT (AGL2013-49083-C3-1-R and AGL2016-79113-R to
   R.M.L.-R.; SAF 2014-52223-C2-2-R granted to N.C.), Generalitat de
   Catalunya (grant 2014SGR773 to R.M.L.-R. and 2014SGR574 to F.J.-A), the
   Fundacio La Marato de TV3 (grant 87/C/2016 to N.C.), the Centro de
   Investigation Biomedica en Red de la Fisiopatologia de la Obesidad y
   Nutricion (CIBEROBN), and Projectes de Recerca per a Investigadors
   Novells a la Universitat Internacional de Catalunya (2015) granted to
   R.R.-R.
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NR 52
TC 16
Z9 17
U1 1
U2 13
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1613-4125
EI 1613-4133
J9 MOL NUTR FOOD RES
JI Mol. Nutr. Food Res.
PD SEP
PY 2017
VL 61
IS 9
AR 1601010
DI 10.1002/mnfr.201601010
PG 11
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA FF5AO
UT WOS:000408981500015
PM 28319651
DA 2025-06-11
ER

PT J
AU Guo, HH
   Ling, WH
AF Guo, Honghui
   Ling, Wenhua
TI The update of anthocyanins on obesity and type 2 diabetes: Experimental
   evidence and clinical perspectives
SO REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
LA English
DT Article
DE Anthocyanin; Inflammation; Obesity; Oxidative stress; Type 2 diabetes
   mellitus
ID ACTIVATED PROTEIN-KINASE; HIGH-FAT DIET; DEPENDENT SIGNALING PATHWAY;
   INDUCED INSULIN-RESISTANCE; PURPLE CORN COLOR; HUMAN HEPG2 CELLS;
   BODY-WEIGHT GAIN; FED C57BL/6 MICE; METABOLIC SYNDROME; KAPPA-B
AB With the dramatically increasing prevalence of obesity and type 2 diabetes mellitus (T2DM) worldwide, there is an urgent need for new strategies to combat the growing epidemic of these metabolic diseases. Diet is an essential factor affecting the development of and risk for obesity and T2DM and it can either help or hurt. In searching for preventative and therapeutic strategies, it is therefore advantageous to consider the potential of certain foods and their bioactive compounds to reverse or prevent the pathogenic processes associated with metabolic disease. Anthocyanins are naturally occurring polyphenolic compounds abundant in dark-colored fruits, vegetables and grains. Epidemiological studies suggest that increased consumption of anthocyanins lowers the risk of T2DM. Many in vitro and in vivo studies also reveal an array of mechanisms through which anthocyanins could prevent or reverse obesity- and T2DM-related pathologies including promotion of antioxidant and anti-inflammatory activities, improvement of insulin resistance, and hypolipidemic and hypoglycemic actions. Here, we summarize the data on anthocyanin-mediated protection against obesity and T2DM and the underlying mechanisms. Further population-based and long-term human intervention studies are necessary to ultimately evaluate the use of anthocyanins for protection/prevention against the development of obesity and T2DM.
C1 [Guo, Honghui] Shaoguan Univ, Henry Fok Sch Food Sci & Engn, Dept Nutr, Shaoguan 512005, Peoples R China.
   [Ling, Wenhua] Sun Yat Sen Univ, Sch Publ Hlth, Dept Nutr, Guangdong Prov Key Lab Food Nutr & Hlth, Guangzhou 510080, Guangdong, Peoples R China.
C3 Shaoguan University; Sun Yat Sen University
RP Ling, WH (corresponding author), Sun Yat Sen Univ, Sch Publ Hlth, Dept Nutr, Guangdong Prov Key Lab Food Nutr & Hlth, Northern Campus, Guangzhou 510080, Guangdong, Peoples R China.
EM lingwh@mail.sysu.edu.cn
RI Guo, Honghui/J-6355-2014
OI Guo, Honghui/0000-0001-7837-0392
FU National Basic Research Program (973 Program) [2012CB517506]; National
   Natural Science Foundation [81172655, 81372994]
FX This work was supported by grants from the National Basic Research
   Program (973 Program, 2012CB517506) and the National Natural Science
   Foundation (81172655, 81372994).
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NR 97
TC 120
Z9 125
U1 3
U2 107
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1389-9155
EI 1573-2606
J9 REV ENDOCR METAB DIS
JI Rev. Endocr. Metab. Disord.
PD MAR
PY 2015
VL 16
IS 1
BP 1
EP 13
DI 10.1007/s11154-014-9302-z
PG 13
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA CC6RD
UT WOS:000350493800001
PM 25557610
DA 2025-06-11
ER

PT J
AU Kawamoto, R
   Tabara, Y
   Kohara, K
   Kusunoki, T
   Abe, M
   Miki, T
AF Kawamoto, Ryuichi
   Tabara, Yasuharu
   Kohara, Katsuhiko
   Kusunoki, Tomo
   Abe, Masanori
   Miki, Tetsuro
TI Serum Uric Acid Is More Strongly Associated with Impaired Fasting
   Glucose in Women than in Men from a Community-Dwelling Population
SO PLOS ONE
LA English
DT Article
ID HYPERTENSION; INSULIN; STRESS; RISK
AB Serum uric acid (SUA) levels are associated with metabolic syndrome (MetS) and its components such as glucose intolerance and type 2 diabetes. It is unknown whether there are gender-specific differences regarding the relationship between SUA levels, impaired fasting glucose (IFG) and newly detected diabetes. We recruited 1,209 men aged 60 +/- 15 (range, 19-89) years and 1,636 women aged 63 +/- 12 (range, 19-89) years during their annual health examination from a single community. We investigated the association between SUA levels and six categories according to fasting plasma glucose (FPG) level {normal fasting glucose (NFG), <100 mg/dL; high NFG-WHO, 100 to 109 mg/dL; IFG-WHO, 110 to 125 mg/dL; IFG-ADA, 100 to 125 mg/dL; newly detected diabetes, >= 126 mg/dL; known diabetes} SUA levels were more strongly associated with the different FPG categories in women compared with men. In women, the associations remained significant for IFG-WHO (OR, 1.23, 95% CI, 1.00-1.50) and newly detected diabetes (OR, 1.33, 95% CI, 1.03-1.72) following multivariate adjustment. However, in men all the associations were not significant. Thus, there was a significant interaction between gender and SUA level for newly detected diabetes (P = 0.005). SUA levels are associated with different categories of impaired fasting glucose in participants from community-dwelling persons, particularly in women.
C1 [Kawamoto, Ryuichi; Kusunoki, Tomo; Abe, Masanori] Ehime Univ, Grad Sch Med, Dept Community Med, Matsuyama, Ehime 790, Japan.
   [Tabara, Yasuharu] Kyoto Univ, Ctr Genom Med, Grad Sch Med, Kyoto, Japan.
   [Miki, Tetsuro] Ehime Univ, Grad Sch Med, Dept Geriatr Med, Matsuyama, Ehime 790, Japan.
C3 Ehime University; Kyoto University; Ehime University
RP Kawamoto, R (corresponding author), Ehime Univ, Grad Sch Med, Dept Community Med, Matsuyama, Ehime 790, Japan.
EM rykawamo@m.ehime-u.ac.jp
FU Foundation for Development of Community; Grants-in-Aid for Scientific
   Research [23390188, 25670353] Funding Source: KAKEN
FX This work was supported in part by a grant-in-aid for Scientific
   Research from the Foundation for Development of Community (2012). No
   additional external funding received for this study. The funders had no
   role in study design, data collection and analysis, decision to publish,
   or preparation of the manuscript.
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NR 20
TC 27
Z9 28
U1 0
U2 2
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JUN 13
PY 2013
VL 8
IS 6
AR e65886
DI 10.1371/journal.pone.0065886
PG 5
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 172XB
UT WOS:000321038800065
PM 23785457
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Yang, WL
   Yu, Y
   Sun, YR
   Ge, RX
   Yin, JW
   Dong, YB
   Yang, YY
   Xu, YH
   Li, Q
   Du, WM
AF Yang, W. L.
   Yu, Y.
   Sun, Y. R.
   Ge, R. X.
   Yin, J. W.
   Dong, Y. B.
   Yang, Y. Y.
   Xu, Y. H.
   Li, Q.
   Du, W. M.
TI Mechanochemical depolymerisation, chemical structure, and in
   vitro prebiotic potential of glucans derived from microcrystalline
   cellulose
SO ACTA ALIMENTARIA
LA English
DT Article
DE microcrystalline cellulose; diluted acid impregnation and ball-milling;
   glucans; in vitro prebiotic assessment
ID INULIN; WATER; HEMICELLULOSES; PRETREATMENT
AB Conversion of economic microcrystalline cellulose (MCC) into high value-added prebiotic glucans, is not only stimulates utilisation of renewable lignocellulosic biomass, but also provides cheap prebiotics to reduce high incidence of obesity and metabolic syndrome. Herein, glucans (C-0.25-C-0.50-C-1.00) from MCC were prepared by pre-impregnation with dilute sulphuric acid (0.25-0.50-1.00%) and ball-milling treatment for 1 h. NMR spectroscopy and gel-permeation chromatography of the glucan products showed a significant reduction in the degree of polymerisation (DP) and molecular weights (Mw). All prepared glucans improved gut stress evaluated by in vitro digestion and fermentation (young and aging mouse faecal inocula). C-1.00 with lower DP and Mw showed better water solubility, earlier peak, and exhibited increased 1-diphenyl-2-picrylhydrazyl activity, higher ratios of Lactobacillus to Escherichia coli, and a higher level of short chain fatty acids better than C-0.25 and C-0.50 treatment (P < 0.05). Better prebiotic effects were observed in aging mice than in young mice. The highest ratio of Lactobacillus to E. coli was a 2.13-fold increase for aging mice compared to a 1.79-fold increase for young mice, relative to the initial value after C-1.00 treatment. The study provides a novel pathway and a new resource for producing glucan.
C1 [Yang, W. L.; Yu, Y.; Sun, Y. R.; Ge, R. X.; Yin, J. W.; Dong, Y. B.; Yang, Y. Y.; Du, W. M.] Beijing Forestry Univ, Beijing Key Lab Forest Food Proc & Safety, Beijing 100083, Peoples R China.
   [Yang, W. L.; Yu, Y.; Sun, Y. R.; Ge, R. X.; Yin, J. W.; Dong, Y. B.; Yang, Y. Y.; Du, W. M.] Beijing Forestry Univ, Dept Food Sci & Engn, Coll Biol Sci & Biotechnol, Beijing 100083, Peoples R China.
   [Xu, Y. H.] Beijing Forestry Univ, Sch Ecol & Nat Conservat, Beijing 100083, Peoples R China.
   [Li, Q.] Tsinghua Univ, Dept Chem Engn, Key Lab Ind Biocatalysis, Beijing 100084, Peoples R China.
C3 Beijing Forestry University; Beijing Forestry University; Beijing
   Forestry University; Tsinghua University
RP Du, WM (corresponding author), Beijing Forestry Univ, Beijing Key Lab Forest Food Proc & Safety, Beijing 100083, Peoples R China.; Du, WM (corresponding author), Beijing Forestry Univ, Dept Food Sci & Engn, Coll Biol Sci & Biotechnol, Beijing 100083, Peoples R China.
EM weimindu@bjfu.edu.cn
FU National Key R&D Program of China [2021YFC2103100]
FX <BOLD>Acknowledgments</BOLD> This work was supported by the National Key
   R&D Program of China (No. 2021YFC2103100) .
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NR 21
TC 0
Z9 0
U1 3
U2 4
PU AKADEMIAI KIADO ZRT
PI BUDAPEST
PA BUDAFOKI UT 187-189-A-3, H-1117 BUDAPEST, HUNGARY
SN 0139-3006
EI 1588-2535
J9 ACTA ALIMENT HUNG
JI Acta Aliment.
PD JUN
PY 2024
VL 53
IS 2
BP 247
EP 256
DI 10.1556/066.2024.00023
PG 10
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA WX7A3
UT WOS:001258223500007
DA 2025-06-11
ER

PT J
AU Pinaffi-Langley, ACD
   Dajani, RM
   Prater, MC
   Nguyen, HV
   Vrancken, K
   Hays, FA
   Hord, NG
AF Pinaffi-Langley, Ana Clara da C.
   Dajani, Rosa M.
   Prater, M. Catherine
   Nguyen, Hoang Van M.
   Vrancken, Kurt
   Hays, Franklin A.
   Hord, Norman G.
TI Dietary Nitrate from Plant Foods: A Conditionally Essential Nutrient for
   Cardiovascular Health
SO ADVANCES IN NUTRITION
LA English
DT Article
DE nitrate; nitric oxide; nitric oxide synthase; nitrite; vasodilation;
   gasotransmitter
ID NITRIC-OXIDE SYNTHASE; BEETROOT JUICE SUPPLEMENTATION; LOWERS
   BLOOD-PRESSURE; INORGANIC NITRATE; ENDOTHELIAL FUNCTION; PLASMA NITRITE;
   DOUBLE-BLIND; MOLECULAR-MECHANISMS; METABOLIC SYNDROME; VASCULAR-DISEASE
AB Under specific conditions, such as catabolic stress or systemic inflammation, endogenous nutrient production becomes insufficient and exogenous supplementation (for example, through dietary intake) is required. Herein, we propose consideration of a dietary nitrate from plant foods as a conditionally essential nutrient for cardiovascular health based on its role in nitric oxide homeostasis. Nitrate derived from plant foods may function as a conditionally essential nutrient, whereas nitrate obtained from other dietary sources, such as drinking water and cured/processed meats, warrants separate consideration because of the associated health risks. We have surveyed the literature and summarized epidemiological evidence regarding the effect of dietary nitrate on cardiovascular disease and risk factors. Meta-analyses and population-based observational studies have consistently demonstrated an inverse association of dietary nitrate with blood pressure and cardiovascular disease outcomes. Considering the available evidence, we suggest 2 different approaches to providing dietary guidance on nitrate from plant-based dietary sources as a nutrient: the Dietary Reference Intakes developed by the National Academies of Sciences, Engineering, and Medicine, and the dietary guidelines evaluated by the Academy of Nutrition and Dietetics. Ultimately, this proposal underscores the need for food-based dietary guidelines to capture the complex and context-dependent relationships between nutrients, particularly dietary nitrate, and health.
C1 [Pinaffi-Langley, Ana Clara da C.; Nguyen, Hoang Van M.; Hays, Franklin A.; Hord, Norman G.] Univ Oklahoma, Coll Allied Hlth, Dept Nutr Sci, Hlth Sci Ctr, Oklahoma City 73104, OK USA.
   [Dajani, Rosa M.] Univ Calif San Francisco, Nutr & Food Serv, San Francisco Hlth, San Francisco, CA USA.
   [Prater, M. Catherine] Univ Georgia, Dept Foods & Nutr, Dawson Hall, Athens, GA USA.
   [Vrancken, Kurt; Hord, Norman G.] Oklahoma State Univ, Coll Educ & Human Sci, Dept Nutr Sci, Stillwater 74075, OK USA.
C3 University of Oklahoma System; University of Oklahoma Health Sciences
   Center; University of California System; University of California San
   Francisco; University System of Georgia; University of Georgia; Oklahoma
   State University System; Oklahoma State University - Stillwater
RP Hord, NG (corresponding author), Univ Oklahoma, Coll Allied Hlth, Dept Nutr Sci, Hlth Sci Ctr, Oklahoma City 73104, OK USA.; Hord, NG (corresponding author), Oklahoma State Univ, Coll Educ & Human Sci, Dept Nutr Sci, Stillwater 74075, OK USA.
EM norman.hord@okstate.edu
RI Hays, Franklin/MEO-0717-2025; Hord, Norman/E-5213-2019
OI Hord, Norman/0000-0002-7505-4180; da Costa Pinaffi Langley, Ana
   Clara/0000-0001-6354-6658
FU OU Health Harold Hamm Diabetes Center; Celia Strickland Austin and G.
   Kenneth Austin III Professorship in Public Health and Human Sciences at
   Oregon State University
FX This work was supported by OU Health Harold Hamm Diabetes Center and the
   Celia Strickland Austin and G. Kenneth Austin III Professorship in
   Public Health and Human Sciences at Oregon State University. Supporting
   sources had no involvement in this publication.
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NR 161
TC 12
Z9 12
U1 1
U2 10
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 2161-8313
EI 2156-5376
J9 ADV NUTR
JI Adv. Nutr.
PD JAN
PY 2024
VL 15
IS 1
AR 100158
DI 10.1016/j.advnut.2023.100158
EA DEC 2023
PG 15
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA ES2I9
UT WOS:001140842600001
PM 38008359
OA hybrid, Green Accepted
DA 2025-06-11
ER

PT J
AU Mooradian, AD
AF Mooradian, Arshag D.
TI Diabetes-related perturbations in the integrity of physiologic barriers
SO JOURNAL OF DIABETES AND ITS COMPLICATIONS
LA English
DT Article
DE Blood-retinal barrier; Blood-brain barrier; Diabetic nephropathy;
   Retinopathy
ID BLOOD-TESTIS BARRIER; PROTEIN-KINASE-C; LUNG-FUNCTION; BRAIN-BARRIER;
   CEREBRAL MICROVESSELS; REPRODUCTIVE FUNCTION; ALBUMIN PERMEABILITY;
   PULMONARY-FUNCTION; METABOLIC SYNDROME; SKIN COLLAGEN
AB One of the hallmarks of health is the integrity of barriers at the cellular and tissue levels. The two cardinal functions of barriers include preventing access of deleterious elements of the environment (barrier function) while facilitating the transport of essential ions, signaling molecules and nutrients needed to maintain the internal milieu (transport function). There are several cellular and subcellular barriers and some of these barriers can be interrelated. The principal physiologic barriers include blood-retinal barrier, blood-brain barrier, blood testis barrier, renal glomerular/tubular barrier, intestinal barrier, pulmonary blood-alveolar barrier, blood placental barrier and skin barrier. Tissue specific barriers are the result of the vasculature, cellular composition of the tissue and extracellular matrix within the tissue. Uncontrolled diabetes and acute hyperglycemia may disrupt the integrity of physiologic barriers, primarily through altering the vascular integrity of the tissues and may well contribute to the clinically recognized complications of diabetes. Although diabetes is a systemic disease, some of the organs display clinically significant deterioration in function while others undergo sub clinical changes. The pathophysiology of the disruption of these barriers is not entirely clear but it may be related to diabetes-related cellular stress. Understanding the mechanisms of diabetes related dysfunction of various physiologic barriers might help identifying novel therapeutic targets for reducing clinically significant complications of diabetes.
C1 [Mooradian, Arshag D.] Univ Florida, Coll Med, Dept Med, Div Endocrinol Diabet & Metab, Jacksonville, FL 32209 USA.
   [Mooradian, Arshag D.] Univ Florida, Coll Med, Dept Med, 653-1 West 8th St,4th Floor LRC, Jacksonville, FL 32209 USA.
C3 State University System of Florida; University of Florida; State
   University System of Florida; University of Florida
RP Mooradian, AD (corresponding author), Univ Florida, Coll Med, Dept Med, 653-1 West 8th St,4th Floor LRC, Jacksonville, FL 32209 USA.
EM arshag.mooradian@jax.ufl.edu
RI Mooradian, Arshag/IAP-5640-2023
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NR 146
TC 7
Z9 7
U1 2
U2 10
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1056-8727
EI 1873-460X
J9 J DIABETES COMPLICAT
JI J. Diabetes Complications
PD AUG
PY 2023
VL 37
IS 8
AR 108552
DI 10.1016/j.jdiacomp.2023.108552
EA JUN 2023
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA M9AP9
UT WOS:001033071300001
PM 37356233
DA 2025-06-11
ER

PT J
AU Zong, L
   Liang, Z
AF Zong, Liang
   Liang, Zhou
TI Apoptosis-inducing factor: a mitochondrial protein associated with
   metabolic diseases-a narrative review
SO CARDIOVASCULAR DIAGNOSIS AND THERAPY
LA English
DT Review
DE Apoptosis-inducing factor (AIF); oxidoreductase; apoptosis; metabolic
   diseases; mitochondria
ID CELL-DEATH; FACTOR AIF; PROSTATE-CANCER; NUCLEAR TRANSLOCATION;
   ACTIVATION; MUTATION; DEFICIENCY; SPECTRUM; ISOFORM; RELEASE
AB Background and Objective: Apoptosis-inducing factor (AIF), a flavin protein in mitochondria, is originally found to induce apoptosis under the stimulation of pro-apoptotic factors. As a mitochondrial flavin adenine dinucleotide-dependent oxidoreductase, AIF is involved in the regulation of mammalian cell metabolism by regulating respiratory enzyme activity, antioxidant stress, promoting mitochondrial autophagy and glucose uptake, etc. Herein, we focused on the research progress regarding the molecular mechanism of AIF in metabolic mediation and the recent research on AIF in metabolic diseases, as well as the AIFmediated apoptotic process.Methods: Articles for this paper were obtained by reviewing the literature related to the role of AIF in metabolic diseases on PubMed. The search terms included the following: "apoptosis", "metabolism" or "metabolic diseases" plus "apoptosis-inducing factor". The titles, abstracts, and full texts of relevant English language publications published from October 1996 to June 2022 were manually screened to clarify the role of AIF in metabolic diseases.Key Content and Findings: We found that AIF played an important role in a variety of metabolically related diseases, such as diabetes, obesity, metabolic syndrome, and tumor metabolism, by mediating apoptosis.Conclusions: We summarized the important role of AIF in a variety of metabolic diseases, which might help to further expand the understanding of AIF and to develop AIF-related therapeutic targets.
C1 [Zong, Liang] Chinese Peoples Liberat Army Gen Hosp, Coll Otolaryngol Head & Neck Surg, 28 Fuxing Rd, Beijing 100853, Peoples R China.
   [Zong, Liang] Natl Clin Res Ctr Otolaryngol Dis, Beijing, Peoples R China.
   [Liang, Zhou] Cent Med Dist Chinese PLA Gen Hosp, Zhantansi Outpatient, Beijing, Peoples R China.
C3 Chinese People's Liberation Army General Hospital
RP Zong, L (corresponding author), Chinese Peoples Liberat Army Gen Hosp, Coll Otolaryngol Head & Neck Surg, 28 Fuxing Rd, Beijing 100853, Peoples R China.
EM zong_l2021@163.com
RI Zhou, Liang/AHD-1410-2022
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NR 109
TC 12
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PU AME PUBLISHING COMPANY
PI SHATIN
PA FLAT-RM C 16F, KINGS WING PLAZA 1, NO 3 KWAN ST, SHATIN, HONG KONG
   00000, PEOPLES R CHINA
SN 2223-3652
EI 2223-3660
J9 CARDIOVASC DIAGN THE
JI Cardiovisc. Diagn. Ther.
PD JUN
PY 2023
VL 13
IS 3
BP 609
EP 622
DI 10.21037/cdt-23-123
EA JUN 2023
PG 14
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA CE5W6
UT WOS:001016603000001
PM 37405018
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Mateos, R
   Salvador, MD
   Fregapane, G
   Goya, L
AF Mateos, Raquel
   Desamparados Salvador, Maria
   Fregapane, Giuseppe
   Goya, Luis
TI Why Should Pistachio Be a Regular Food in Our Diet?
SO NUTRIENTS
LA English
DT Review
DE pistachio; prevalent chronic diseases; nuts; nutritional value; health
   benefits; barriers; facilitator
ID TREE NUT CONSUMPTION; CHIOS MASTIC GUM; VERA L. NUT; ENDOTHELIAL
   FUNCTION; HEALTH-BENEFITS; BODY-WEIGHT; PHYSICOCHEMICAL PROPERTIES;
   CARDIOVASCULAR-DISEASE; ANTIOXIDANT ACTIVITY; METABOLIC SYNDROME
AB The pistachio is regarded as a relevant source of biologically active components that, compared to other nuts, possess a healthier nutritional profile with low-fat content composed mainly of monounsaturated fatty acids, a high source of vegetable protein and dietary fibre, remarkable content of minerals, especially potassium, and an excellent source of vitamins, such as vitamins C and E. A rich composition in terms of phytochemicals, such as tocopherols, carotenoids, and, importantly, phenolic compounds, makes pistachio a powerful food to explore its involvement in the prevention of prevalent pathologies. Although pistachio has been less explored than other nuts (walnut, almonds, hazelnut, etc.), many studies provide evidence of its beneficial effects on CVD risk factors beyond the lipid-lowering effect. The present review gathers recent data regarding the most beneficial effects of pistachio on lipid and glucose homeostasis, endothelial function, oxidative stress, and inflammation that essentially convey a protective/preventive effect on the onset of pathological conditions, such as obesity, type 2 diabetes, CVD, and cancer. Likewise, the influence of pistachio consumption on gut microbiota is reviewed with promising results. However, population nut consumption does not meet current intake recommendations due to the extended belief that they are fattening products, their high cost, or teething problems, among the most critical barriers, which would be solved with more research and information.
C1 [Mateos, Raquel; Goya, Luis] CSIC, Inst Food Sci Technol & Nutr ICTAN CSIC, Jose Antonio Novais 10, Madrid 28040, Spain.
   [Desamparados Salvador, Maria; Fregapane, Giuseppe] Univ Castilla La Mancha, Fac Ciencias & Tecnol Quim, Camilo Jose Cela 10, Ciudad Real 13071, Spain.
C3 Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Instituto
   de Ciencia y Tecnologia de Alimentos y Nutricion (ICTAN); Universidad de
   Castilla-La Mancha
RP Mateos, R; Goya, L (corresponding author), CSIC, Inst Food Sci Technol & Nutr ICTAN CSIC, Jose Antonio Novais 10, Madrid 28040, Spain.
EM raquel.mateos@ictan.csic.es; luisgoya@ictan.csic.es
RI Salvador, María/HTL-6185-2023; Martín, Maria Angeles/JAO-0626-2023;
   BRIZ, Raquel/H-9125-2012; Salvador, M Desamparados/B-1059-2015;
   Fregapane, Giuseppe/L-2427-2014
OI Salvador, M Desamparados/0000-0001-5243-815X; Fregapane,
   Giuseppe/0000-0002-7654-5774
FU CSIC [202270E021]
FX This research was funded by project 202270E021 funded by CSIC.
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PU MDPI
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PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD AUG
PY 2022
VL 14
IS 15
AR 3207
DI 10.3390/nu14153207
PG 21
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 3S6CB
UT WOS:000839681400001
PM 35956383
OA Green Published, gold
DA 2025-06-11
ER

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   Chisholm, JD
   Hougland, JL
AF Moose, Jacob E.
   Leets, Katelyn A.
   Mate, Nilamber A.
   Chisholm, John D.
   Hougland, James L.
TI An overview of ghrelinO-acyltransferase inhibitors: a literature
   and patent review for 2010-2019
SO EXPERT OPINION ON THERAPEUTIC PATENTS
LA English
DT Review
DE Ghrelin; ghrelinO-acyltransferase; GHS-R1a receptor;
   membrane-boundO-acyltransferase; protein acylation; diabetes; obesity;
   metabolic syndrome; addiction; alcoholism
ID PRADER-WILLI-SYNDROME; HYPOTHALAMIC ARCUATE NUCLEUS; O-ACYLTRANSFERASE;
   GROWTH-HORMONE; ANOREXIA-NERVOSA; FOOD-INTAKE; CIRCULATING GHRELIN;
   INSULIN-SECRETION; ACYLATED GHRELIN; BETA-CELLS
AB Introduction The peptide hormone ghrelin regulates physiological processes associated with energy homeostasis such as appetite, insulin signaling, glucose metabolism, and adiposity. Ghrelin has also been implicated in a growing number of neurological pathways involved in stress response and addiction behavior. For ghrelin to bind the growth hormone secretagogue receptor 1a (GHS-R1a) and activate signaling, the hormone must first be octanoylated on a specific serine side chain. This key transformation is performed by the enzyme ghrelinO-acyltransferase (GOAT), and therefore GOAT inhibitors may be useful in treating disorders related to ghrelin signaling such as diabetes, obesity, and related metabolic syndromes. Areas covered This report covers ghrelin and GOAT as potential therapeutic targets and summarizes work on GOAT inhibitors through the end of 2019, highlighting recent successes with both peptidomimetics and small molecule GOAT inhibitors as potent modulators of GOAT-catalyzed ghrelin octanoylation. Expert opinion A growing body of biochemical and structural knowledge regarding the ghrelin/GOAT system now enables multiple avenues for identifying and optimizing GOAT inhibitors. We are at the beginning of a new era with increased opportunities for leveraging ghrelin and GOAT in the understanding and treatment of multiple health conditions including diabetes, obesity, and addiction.
C1 [Moose, Jacob E.; Leets, Katelyn A.; Mate, Nilamber A.; Chisholm, John D.; Hougland, James L.] Syracuse Univ, Dept Chem & BioInspired Syracuse, 1-014 Ctr Sci & Technol, Syracuse, NY 13244 USA.
C3 Syracuse University
RP Hougland, JL (corresponding author), Syracuse Univ, Dept Chem & BioInspired Syracuse, 1-014 Ctr Sci & Technol, Syracuse, NY 13244 USA.
EM hougland@syr.edu
RI Mate, Nilamber/HGF-1500-2022
OI Hougland, James/0000-0003-0444-1017; Mate, Nilamber/0000-0002-4441-7188;
   Chisholm, John/0000-0001-9518-2393; Moose, Jacob/0000-0002-8659-1918
FU National Institutes of Health [GM134102]; American Diabetes Association
   [1-16-JDF-042]; Syracuse University
FX This work was supported by grants from the National Institutes of Health
   [GM134102, JL Hougland and JD Chisholm]; the American Diabetes
   Association [1-16-JDF-042, JL Hougland]; and Syracuse University.
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NR 178
TC 18
Z9 23
U1 0
U2 10
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1354-3776
EI 1744-7674
J9 EXPERT OPIN THER PAT
JI Expert Opin. Ther. Patents
PD AUG 2
PY 2020
VL 30
IS 8
BP 581
EP 593
DI 10.1080/13543776.2020.1776263
EA JUN 2020
PG 13
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA NU9FI
UT WOS:000546487700001
PM 32564644
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Sun, XY
   Song, M
   Wang, H
   Zhou, HM
   Wang, F
   Li, Y
   Zhang, Y
   Zhang, W
   Zhong, M
   Ti, Y
AF Sun, Xiaoyan
   Song, Ming
   Wang, Hui
   Zhou, Huimin
   Wang, Feng
   Li, Ya
   Zhang, Yun
   Zhang, Wei
   Zhong, Ming
   Ti, Yun
TI TRB3 gene silencing activates AMPK in adipose tissue with beneficial
   metabolic effects in obese and diabetic rats
SO BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
LA English
DT Article
DE TRB3; AMPK; Insulin resistance; Obesity; Diabetes
ID SKELETAL-MUSCLE; INFLAMMATION; HOMEOSTASIS; STRESS
AB Our previous study had suggested Tribbles homolog 3 (TRB3) might be involved in metabolic syndrome via adipose tissue. Given prior studies, we sought to determine whether TRB3 plays a major role in adipocytes and adipose tissue with beneficial metabolic effects in obese and diabetic rats. Fully differentiated 3T3-L1 adipocytes were incubated to induce insulin resistant adipocytes. Forty male Sprague-Dawley rats were all fed high-fat (HF) diet. Type 2 diabetic rat model was induced by high-fat diet and low-dose streptozotocin (STZ). Compared with control group, in insulin resistant adipocytes, protein levels of insulin receptor substrate-1(IRS-1), glucose transporter 4(GLUT4) and phosphorylated-AMP-activated protein kinase (p-AMPK)were reduced, TRB3 protein level and triglyceride level were significantly increased, glucose uptake was markedly decreased. TRB3 silencing alleviated adipocytes insulin resistance. With TRB3 gene silencing, protein levels of IRS-1, GLUT4 and p-AMPK were significantly increased in adipocytes. TRB3 gene silencing decreased blood glucose, ameliorated insulin sensitivity and adipose tissue remodeling in diabetic rats. TRB3 silencing decreased triglyceride, increased glycogen simultaneously in diabetic epididymal and brown adipose tissues (BAT). Consistently, p-AMPK levels were increased in diabetic epididymal adipose tissue, and BAT after TRB3-siRNA treatment. TRB3silencing increased phosphorylation of Akt in liver, and improved liver insulin resistance. (C) 2017 Published by Elsevier Inc.
C1 [Sun, Xiaoyan; Song, Ming; Wang, Hui; Zhou, Huimin; Wang, Feng; Li, Ya; Zhang, Yun; Zhang, Wei; Zhong, Ming; Ti, Yun] Shandong Univ, Chinese Minist Educ, Qilu Hosp, Key Lab Cardiovasc Remodeling & Funct Res, Jinan 250012, Shandong, Peoples R China.
   [Sun, Xiaoyan; Song, Ming; Wang, Hui; Zhou, Huimin; Wang, Feng; Li, Ya; Zhang, Yun; Zhang, Wei; Zhong, Ming; Ti, Yun] Shandong Univ, Chinese Minist Hlth, State & Shandong Prov Joint Key Lab Translat Card, Qilu Hosp,Dept Cardiol, Jinan 250012, Shandong, Peoples R China.
   [Sun, Xiaoyan] Heze Municipal Hosp, Dept Cardiol, Heze, Shandong, Peoples R China.
C3 Ministry of Education - China; Shandong University; Shandong University
RP Ti, Y (corresponding author), Shandong Univ, Chinese Minist Educ, Qilu Hosp, Key Lab Cardiovasc Remodeling & Funct Res, Jinan 250012, Shandong, Peoples R China.; Ti, Y (corresponding author), Shandong Univ, Chinese Minist Hlth, State & Shandong Prov Joint Key Lab Translat Card, Qilu Hosp,Dept Cardiol, Jinan 250012, Shandong, Peoples R China.
EM ttlxf0713@163.com
RI xiao, yuliang/JFJ-1841-2023; Sun, Xiaoyan/E-6616-2015
FU National Natural Science Foundation of China [81670411, 81471036,
   81470560, 81570400, 81600633, 81300168, 81270352, 81270287, 81100605,
   91439201, 81530014, 81320108004]; National Basic Research Program of
   China (973 Program) [2013CB530703]; Key research and development program
   of Shandong Province [2015GSF118062]; Natural Science Foundation of
   Shandong Province [ZR2014HQ037]; Medicine and Health Science Technology
   development program of Shandong Province [2016WS0091]; Specialized
   Research Fund for the Doctoral Program of Higher Education [SRFDP
   20130131120065]; Program of Introducing Talents of Discipline to
   Universities [B07035]
FX This work was supported by the research grants from the National Natural
   Science Foundation of China (81670411, 81471036, 81470560, 81570400,
   81600633, 81300168, 81270352, 81270287, 81100605, 91439201, 81530014 and
   81320108004),the National Basic Research Program of China (973 Program,
   Grant No. 2013CB530703), Key research and development program of
   Shandong Province (2015GSF118062), the Natural Science Foundation of
   Shandong Province (ZR2014HQ037), Medicine and Health Science Technology
   development program of Shandong Province (2016WS0091), the Specialized
   Research Fund for the Doctoral Program of Higher Education (SRFDP
   20130131120065) and Program of Introducing Talents of Discipline to
   Universities (B07035).
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NR 22
TC 6
Z9 9
U1 1
U2 17
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0006-291X
EI 1090-2104
J9 BIOCHEM BIOPH RES CO
JI Biochem. Biophys. Res. Commun.
PD JUN 17
PY 2017
VL 488
IS 1
BP 22
EP 28
DI 10.1016/j.bbrc.2017.04.154
PG 7
WC Biochemistry & Molecular Biology; Biophysics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics
GA EW6AG
UT WOS:000402587000004
PM 28476619
DA 2025-06-11
ER

PT J
AU Dominguez, LJ
   Barbagallo, M
AF Dominguez, Ligia J.
   Barbagallo, Mario
TI The relevance of nutrition for the concept of cognitive frailty
SO CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE
LA English
DT Review
DE aging; cognition; frailty; inflammation; nutrition
ID ALZHEIMERS-DISEASE; MEDITERRANEAN DIET; OLDER-ADULTS; BRAIN HEALTH;
   DECLINE; IMPAIRMENT; PREVENTION; PHENOTYPE; CONSENSUS; ASSOCIATION
AB Purpose of reviewPhysical and cognitive frailty are interrelated and synergistic syndromes more frequently seen in old age, which represent intermediate stages between aging successfully and disability. Poor nutrition is a fundamental determinant for both conditions, while various dietary components are proposed to prevent and/or improve them. This updated review discusses the possible influence of nutritional factors on cognitive frailty and its potential mediators.Recent findingsOxidative stress, low-grade systemic inflammation, neuroinflammation, and altered autophagy, all associated with obesity, metabolic syndrome and insulin resistance, are proposed mechanisms to explain the influence of nutrition on cognitive health. Even if no single food or supplement has definitively demonstrated to affect physical frailty and cognitive impairment, combining various dietary and lifestyle components in the Mediterranean dietary pattern has shown benefit.SummaryCognitive frailty is a potential useful construct for the early detection of cognitive impairment and physical frailty, in order to implement timely interventions. Validation of this construct is eagerly needed. Nutritional status is a fundamental part of physical frailty, and potentially important in the prevention of cognitive decline. Identifying and treating protein/calorie and individual nutrients insufficiency is mandatory in all older adults. Conversely, overeating in middle age has been associated with cognitive decline in older age. A lifelong balance diet, such as the Mediterranean diet, combined with regular physical and mental exercise, is perhaps the best preventive strategy against cognitive decline in old age.
C1 [Dominguez, Ligia J.; Barbagallo, Mario] Univ Palermo, Dept Internal Med & Geriatr, Geriatr Unit, Viale F Scaduto 6-C, I-90144 Palermo, Italy.
C3 University of Palermo
RP Dominguez, LJ (corresponding author), Univ Palermo, Dept Internal Med & Geriatr, Geriatr Unit, Viale F Scaduto 6-C, I-90144 Palermo, Italy.
EM ligia.dominguez@unipa.it
RI BARBAGALLO, MARIO/K-4794-2017
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NR 53
TC 51
Z9 56
U1 2
U2 80
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1363-1950
EI 1473-6519
J9 CURR OPIN CLIN NUTR
JI Curr. Opin. Clin. Nutr. Metab. Care
PD JAN
PY 2017
VL 20
IS 1
BP 61
EP 68
DI 10.1097/MCO.0000000000000337
PG 8
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA EF3RT
UT WOS:000390242800008
PM 27749714
DA 2025-06-11
ER

PT J
AU Kashima, A
   Higashiyama, Y
   Kubota, M
   Kawaguchi, C
   Takahashi, Y
   Nishikubo, T
AF Kashima, Ayako
   Higashiyama, Yukie
   Kubota, Masaru
   Kawaguchi, Chiharu
   Takahashi, Yukihiro
   Nishikubo, Toshiya
TI Children with Down's syndrome display high rates of hyperuricaemia
SO ACTA PAEDIATRICA
LA English
DT Article
DE Down's syndrome; Hyperuricaemia; Lifestyle-related disease; Nutrient
   intake; Uric acid
ID URIC-ACID; METABOLIC SYNDROME; OXIDATIVE STRESS; ADOLESCENTS;
   PREVALENCE; OBESITY; ANTIOXIDANT; INSULIN; ADULTS; CARE
AB Aim: Several studies show that hyperuricaemia, abnormally high levels of uric acid in the blood, frequently occurs in adult Down's syndrome patients, but paediatric research is scarce. We aimed to clarify its prevalence in paediatric Down's syndrome patients and its association with lifestyle-related laboratory variables and nutritional intake, to consider possible effects in later life.
   Methods: We compared 52 Down's syndrome patients, from one to 15 years of age, with age-matched controls. Hyperuricaemia was defined using reference values established for children, as uric acid z-scores of more than 2.0. Nutritional intake was estimated using 3-day dietary records.
   Results: Hyperuricaemia occurred in 17 Down's patients (32.7%) and was significantly higher in Down's patients than the controls. The prevalence was also significantly higher in males. There were no significant differences between hyperuricaemia-positive and hyperuricaemia-negative patients in terms of age, body mass index standard deviation scores, fasting blood glucose, insulin, homeostasis model assessment-insulin resistance and triglyceride, and purine body intake was similar. There were differences in high-density lipoprotein cholesterol.
   Conclusion: We found high rates of hyperuricaemia from early childhood in Down's syndrome patients. This suggests careful management of Down's syndrome patients, as hyperuricaemia is an independent risk factor for lifestyle-related diseases in adulthood.
C1 [Kashima, Ayako; Higashiyama, Yukie; Kubota, Masaru] Nara Womens Univ, Fac Human Life & Environm, Nara 6308506, Japan.
   [Kawaguchi, Chiharu] Todaiji Med & Educ Ctr, Dept Pediat, Nara, Japan.
   [Takahashi, Yukihiro; Nishikubo, Toshiya] Nara Med Univ Hosp, Dept Neonatal Intens Care Unit, Nara, Japan.
C3 Nara Womens University; Nara Medical University
RP Kubota, M (corresponding author), Nara Womens Univ, Dept Human Life & Environm, Nishi Machi, Nara 6308506, Japan.
EM mkubota@cc.nara-wu.ac.jp
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NR 30
TC 9
Z9 11
U1 0
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0803-5253
EI 1651-2227
J9 ACTA PAEDIATR
JI Acta Paediatr.
PD AUG
PY 2014
VL 103
IS 8
BP E359
EP E364
DI 10.1111/apa.12664
PG 6
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA V43AK
UT WOS:000209654100011
PM 24766390
OA Bronze
DA 2025-06-11
ER

PT J
AU Caprio, M
   Antelmi, A
   Chetrite, G
   Muscat, A
   Mammi, C
   Marzolla, V
   Fabbri, A
   Zennaro, MC
   Fève, B
AF Caprio, Massimiliano
   Antelmi, Antonella
   Chetrite, Gerard
   Muscat, Adeline
   Mammi, Caterina
   Marzolla, Vincenzo
   Fabbri, Andrea
   Zennaro, Maria-Christina
   Feve, Bruno
TI Antiadipogenic Effects of the Mineralocorticoid Receptor Antagonist
   Drospirenone: Potential Implications for the Treatment of Metabolic
   Syndrome
SO ENDOCRINOLOGY
LA English
DT Article
ID HORMONE REPLACEMENT THERAPY; HYPERTENSIVE POSTMENOPAUSAL WOMEN; UNIQUE
   PROGESTOGEN; OXIDATIVE STRESS; ADIPOSE-TISSUE; BLOOD-PRESSURE; 3T3-L1
   CELLS; RAT-HEART; DIFFERENTIATION; 17-BETA-ESTRADIOL
AB The mineralocorticoid receptor (MR) mediates aldosterone-and glucocorticoid-induced adipocyte differentiation. Drospirenone (DRSP) is a potent synthetic antimineralocorticoid with progestogenic and antiandrogenic properties, which is widely used for contraception and hormone replacement therapy. We investigated its potential role on adipocyte differentiation. The effects of DRSP were studied in murine preadipocyte cell lines and primary cultures of human preadipocytes. Differentiation markers and mechanisms underlying phenotypic variations in response to DRSP were explored. Early exposure to DRSP during differentiation led to a marked dose-dependent inhibition of adipose differentiation and triglyceride accumulation in 3T3-L1 and 3T3-F442A cells. DRSP also markedly inhibited adipose conversion of human primary preadipocytes derived from visceral (mesenteric and epicardial) and subcutaneous fat. This effect was MR-dependent and did not involve the glucocorticoid, androgen, or progesterone receptors. DRSP inhibited clonal expansion of preadipocytes and decreased expression of PPAR gamma, a key transcriptional mediator of adipogenesis, but had no effect on lipolysis, glucose uptake, and PPAR gamma binding to its ligands. DRSP exerts a potent antiadipogenic effect that is related to an alteration of the transcriptional control of adipogenesis via an antagonistic effect on the MR. Selective MR blockade therefore has promise as a novel therapeutic option for the control of excessive adipose tissue deposition and its related metabolic complications. (Endocrinology 152: 113-125, 2011)
C1 [Caprio, Massimiliano; Antelmi, Antonella; Mammi, Caterina] Ist Ricovero & Cura Carattere Sci San Raffaele Pi, Ctr Clin & Basic Res, I-00163 Rome, Italy.
   [Chetrite, Gerard; Muscat, Adeline; Feve, Bruno] INSERM, U693, F-94276 Le Kremlin Bicetre, France.
   [Chetrite, Gerard; Muscat, Adeline; Feve, Bruno] Univ Paris Sud, Fac Med Paris Sud, UMR S693, F-94276 Le Kremlin Bicetre, France.
   [Chetrite, Gerard; Feve, Bruno] Hop Bicetre, AP HP, F-94276 Le Kremlin Bicetre, France.
   [Marzolla, Vincenzo; Fabbri, Andrea] Univ Tor Vergata, St Eugenio Hosp, Dept Internal Med, Endocrinol Unit, I-00133 Rome, Italy.
   [Marzolla, Vincenzo; Fabbri, Andrea] Univ Tor Vergata, CTO A Alesini Hosp, Dept Internal Med, Endocrinol Unit, I-00133 Rome, Italy.
   [Marzolla, Vincenzo] San Raffaele Sulmona, I-67039 Laquila, Italy.
   [Zennaro, Maria-Christina] Paris Cardiovasc Res Ctr PARCC, INSERM, U970, F-75015 Paris, France.
   [Zennaro, Maria-Christina] Univ Paris 05, UMR S970, F-75015 Paris, France.
   [Zennaro, Maria-Christina] Hop Europeen Georges Pompidou, AP HP, F-75015 Paris, France.
C3 Center Clinical & Basic Research; Institut National de la Sante et de la
   Recherche Medicale (Inserm); Universite Paris Saclay; Universite Paris
   Saclay; Assistance Publique Hopitaux Paris (APHP); Hopital Universitaire
   Antoine-Beclere - APHP; Hopital Universitaire Bicetre - APHP;
   Sant'Eugenio Hospital; University of Rome Tor Vergata; University of
   Rome Tor Vergata; Institut National de la Sante et de la Recherche
   Medicale (Inserm); Universite Paris Cite; Universite Paris Cite;
   Assistance Publique Hopitaux Paris (APHP); Universite Paris Cite;
   Hopital Universitaire Europeen Georges-Pompidou - APHP
RP Caprio, M (corresponding author), Ist Ricovero & Cura Carattere Sci San Raffaele Pi, Ctr Ric, Via Bonacolsi 81, I-00163 Rome, Italy.
EM mas-similiano.caprio@sanraffaele.it
RI Antelmi, Annarita/AAK-1508-2021; Zennaro, Maria-Christina/IZP-8913-2023;
   Mammi, Caterina/O-1047-2013; Caprio, Massimiliano/J-3020-2012; Marzolla,
   Vincenzo/K-7769-2016
OI Caprio, Massimiliano/0000-0003-0722-7163; Zennaro,
   Maria-Christina/0000-0001-5449-9191; Feve, Bruno/0000-0001-6577-9009;
   Marzolla, Vincenzo/0000-0002-2943-7631; mammi,
   caterina/0000-0002-2687-4422
FU Instituto di Ricovero e Cura a Carattere Scientifico San Raffaele,
   University Tor Vergata (Progetti Ricerca Interesse Nazionale Ministero
   dell'Universita e della Ricerca); Institut National de la Sante et de la
   Recherche Medicale; Universities Paris Sud and Paris Descartes;
   University of Rome Tor Vergata (Progetti Ricerca Interesse Nazionale
   Ministero dell'Universita e della Ricerca)
FX This work was supported by institutional funding from Instituto di
   Ricovero e Cura a Carattere Scientifico San Raffaele, University Tor
   Vergata (Progetti Ricerca Interesse Nazionale Ministero dell'Universita
   e della Ricerca, 2007, to A.F.), Institut National de la Sante et de la
   Recherche Medicale, and Universities Paris Sud and Paris Descartes. M.C.
   was recipient of a fellowship from the University of Rome Tor Vergata
   for the year 2007 (Progetti Ricerca Interesse Nazionale Ministero
   dell'Universita e della Ricerca, 2005, to A.F.).
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NR 42
TC 102
Z9 111
U1 0
U2 4
PU ENDOCRINE SOC
PI CHEVY CHASE
PA 8401 CONNECTICUT AVE, SUITE 900, CHEVY CHASE, MD 20815-5817 USA
SN 0013-7227
EI 1945-7170
J9 ENDOCRINOLOGY
JI Endocrinology
PD JAN
PY 2011
VL 152
IS 1
BP 113
EP 125
DI 10.1210/en.2010-0674
PG 13
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 698DT
UT WOS:000285573000013
PM 21084448
OA Bronze
DA 2025-06-11
ER

PT J
AU Bréger, G
   André, A
   Cotte, C
   Hammaidi, A
   Amérand, A
   Faivre, C
   Martignat, L
   Mallem, MY
AF Breger, Gwendoline
   Andre, Agnes
   Cotte, Cesar
   Hammaidi, Abderrahim
   Amerand, Aline
   Faivre, Claude
   Martignat, Lionel
   Mallem, Mohamed Yassine
TI Anti-Obesity Effects Evaluation of a Blackcurrant Leaf Standardized
   Hydro-Alcoholic Extract in Wistar Rat Subjected to a High-Fat Diet
SO BIOLOGY-BASEL
LA English
DT Article
DE blackcurrant (Ribes nigrum); quercetin; polyphenols;
   obesity; rat
ID OXIDATIVE STRESS; METABOLIC SYNDROME; INDUCED OBESITY; GUT MICROBIOTA;
   QUERCETIN; HYPERGLYCEMIA; ANTIOXIDANT; RIBES; ACIDS
AB Blackcurrant (BC) extract was reported to exert anti-obesity effects. However, it is unknown whether BC extract with a composition close to the totum differentially affects obesity when compared to one of its active compounds. We evaluated the anti-obesity effects of a BC standardized hydro-alcoholic leaf extract (BC-HLE) in an HFD-induced obesity rat model and compared them with quercetin (QUE). Thirty-six 12-week-old Wistar rats were divided into six groups: control, HFD, BC-HLE- (41 and 50 mg/kg) and QUE- (0.9 and 50 mg/kg) supplemented HFD rats for 12 weeks. HFD rats developed a moderate obesity, associated with a gut dysbiosis and a change in their total antioxidant capacity. The increase in body weight gain was prevented only by the low dose of BC-HLE and the high dose of QUE. The impaired glucose tolerance by HFD was attenuated by the low dose of QUE. Hepatic glutathione peroxidase activity was increased in the HFD group and only BC-HLE supplementation counteracted this change. The low BC-HLE dose tended to reduce the HFD-induced gut dysbiosis. These findings suggest that while QUE has beneficial effects on obesity-related disorders, the BC-HLE may offer even greater overall benefits and could contribute to preventing obesity and related conditions.
C1 [Breger, Gwendoline; Andre, Agnes; Martignat, Lionel; Mallem, Mohamed Yassine] Oniris, Nutr Pathophysiol & Pharmacol NP3, 101 route Gachet, F-44307 Nantes 3, France.
   [Breger, Gwendoline; Hammaidi, Abderrahim; Faivre, Claude] Wamine Ind, 1 ZI Taillis, F-49270 Champtoceaux, France.
   [Cotte, Cesar] Naturopole Nutr Sante, PiLeJe Ind, F-03220 St Bonnet De Rochefort, France.
   [Amerand, Aline] Univ Brest, ORPHY EA4324, 6 Ave Victor Gorgeu, F-29200 Brest, France.
C3 Ecole Nationale Veterinaire, Agroalimentaire et de l'Alimentation
   Nantes-Atlantique; Universite de Bretagne Occidentale
RP Bréger, G; Mallem, MY (corresponding author), Oniris, Nutr Pathophysiol & Pharmacol NP3, 101 route Gachet, F-44307 Nantes 3, France.; Bréger, G (corresponding author), Wamine Ind, 1 ZI Taillis, F-49270 Champtoceaux, France.
EM g.breger@wamine.com; agnes.andre@oniris-nantes.fr;
   c.cotte@pileje-industrie.com; c.faivre@wamine.com;
   lionel.martignat@oniris-nantes.fr; yassine.mallem@oniris-nantes.fr
RI MALLEM, yassine/AHD-1776-2022
OI MALLEM, yassine/0000-0001-5867-580X
FU Wamine
FX This research was funded by Wamine as a part of a thesis study.
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NR 60
TC 0
Z9 0
U1 2
U2 2
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2079-7737
J9 BIOLOGY-BASEL
JI Biology-Basel
PD DEC
PY 2024
VL 13
IS 12
AR 999
DI 10.3390/biology13120999
PG 17
WC Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics
GA Q9H3E
UT WOS:001387692000001
PM 39765666
OA gold
DA 2025-06-11
ER

PT J
AU Sakurai, M
   Weber, P
   Wolff, G
   Wieder, A
   Szendroedi, J
   Herzig, S
   Uestuenel, BE
AF Sakurai, Minako
   Weber, Peter
   Wolff, Gretchen
   Wieder, Annika
   Szendroedi, Julia
   Herzig, Stephan
   uestuenel, Bilgen Ekim
TI TSC22D4 promotes TGFb1-induced activation of hepatic stellate cells
SO BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
LA English
DT Article
DE Hepatic stellate cells; TGF b1 signaling; Liver fibrosis
ID NONALCOHOLIC STEATOHEPATITIS; FIBROSIS
AB Non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH) and liver fibrosis emerge as progressive liver diseases that accompany metabolic syndrome usually characterized by obesity, insulin resistance and type 2 diabetes. Currently no FDA approved treatments exist for the treatment of NASH and liver fibrosis, which requires a better knowledge of the underlying molecular mechanisms. TSC22D4 belongs to the TSC-22 protein family, the members of which are regulated by inflammatory and stress signals. Interestingly, patients with type 2 diabetes, with NAFLD as well as with NASH all have elevated levels of hepatic TSC22D4 expression. Previous studies with targeted deletion of TSC22D4 specifically in hepatocytes showed that TSC22D4 not only acts as a critical controller of diabetic hyperglycemia, but also contributes to NAFLD/NASH progression. To gain better insight into the development of progressive liver diseases, here we studied the function of TSC22D4 in hepatic stellate cells (HSCs), which play a key role in the pathogenesis of liver fibrosis. Our results indicated that TSC22D4 contributes to TGFb1-mediated activation of HSCs and promotes their proliferation and migration. RNASequencing analysis revealed that TSC22D4 initiates transcriptional events associated with HSC activation. Overall, our findings establish TSC22D4 as a key hub in the development of liver fibrosis, acting across different cellular compartments. Combinatorial TSC22D4 targeting in both hepatocytes and HSC may thus show superior efficacy against progressive liver disease. (c) 2022 Elsevier Inc. All rights reserved.
C1 [Sakurai, Minako; Weber, Peter; Wolff, Gretchen; Wieder, Annika; Szendroedi, Julia; Herzig, Stephan; uestuenel, Bilgen Ekim] Helmholtz Ctr, Inst Diabet & Canc IDC, Helmholtz Diabet Ctr, Neuherberg, Germany.
   [Sakurai, Minako; Wolff, Gretchen; Wieder, Annika; Szendroedi, Julia; Herzig, Stephan; uestuenel, Bilgen Ekim] Heidelberg Univ Hosp, Joint Heidelberg IDC Translat Diabet Program, Inner Med 1, Heidelberg, Germany.
   [Sakurai, Minako; Wolff, Gretchen; Wieder, Annika; Szendroedi, Julia; Herzig, Stephan; uestuenel, Bilgen Ekim] German Ctr Diabet Res DZD, Neuherberg, Germany.
   [Weber, Peter] Helmholtz Zentrum Munchen Deutsch Forschungszentr, Res Unit Radiat Cytogenet, Neuherberg, Germany.
   [Weber, Peter] Helmholtz Zentrum Munchen Deutsch Forschungszentr, Clin Cooperat Grp Personalized Radiotherapy Head, Neuherberg, Germany.
C3 Helmholtz Association; Helmholtz-Center Munich - German Research Center
   for Environmental Health; Ruprecht Karls University Heidelberg; German
   Center for Diabetes Research (DZD); Helmholtz Association;
   Helmholtz-Center Munich - German Research Center for Environmental
   Health; Helmholtz Association; Helmholtz-Center Munich - German Research
   Center for Environmental Health
RP Uestuenel, BE (corresponding author), Helmholtz Ctr, Inst Diabet & Canc IDC, Helmholtz Diabet Ctr, Neuherberg, Germany.
EM bilgen.ekimuestuenel@med.uni-heidelberg.de
RI Herzig, Stephan/MDT-3563-2025
OI Ekim, Bilgen/0000-0003-0025-1822
FU DFG [EK-108/1-1, SFB1118]; Japan Society for the Promotion of Science
   (JSPS)
FX This work was supported by DFG Grants EK-108/1-1 to B.E.U and SFB1118 to
   S.H., Japan Society for the Promotion of Science (JSPS) to M.S. We also
   thank to Kerry Gould and Dr. Anne Dropmann in Prof. Steven Dooley's lab
   (Universit_atsmedizin Mannheim) for providing training for HSC
   isolation.
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NR 35
TC 3
Z9 3
U1 0
U2 6
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0006-291X
EI 1090-2104
J9 BIOCHEM BIOPH RES CO
JI Biochem. Biophys. Res. Commun.
PD AUG 27
PY 2022
VL 618
BP 46
EP 53
DI 10.1016/j.bbrc.2022.05.100
EA JUN 2022
PG 8
WC Biochemistry & Molecular Biology; Biophysics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics
GA 3B1BW
UT WOS:000827684400007
PM 35714570
DA 2025-06-11
ER

PT J
AU Martins, AC
   Lopes, ACBA
   Urbano, MR
   Carvalho, MDH
   Silva, AMR
   Tinkov, AA
   Aschner, M
   Mesas, AE
   Silbergeld, EK
   Paoliello, MMB
AF Martins, Airton C.
   Almeida Lopes, Ana Carolina B.
   Urbano, Mariana R.
   Carvalho, Maria de Fatima H.
   Silva, Ana Maria R.
   Tinkov, Alexey A.
   Aschner, Michael
   Mesas, Arthur E.
   Silbergeld, Ellen K.
   Paoliello, Monica M. B.
TI An updated systematic review on the association between Cd exposure,
   blood pressure and hypertension
SO ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
LA English
DT Review
DE Blood; Blood pressure; Cadmium; Hypertension; Smoking; Systematic
   review; Urine
ID KOREAN NATIONAL-HEALTH; CADMIUM BODY BURDEN; URINARY CADMIUM;
   KIDNEY-FUNCTION; CARDIOVASCULAR-DISEASE; ENVIRONMENTAL EXPOSURE;
   GENERAL-POPULATION; METABOLIC SYNDROME; OXIDATIVE STRESS; ANGIOTENSIN-II
AB Background: Since the first report by Perry et al. (1955), most studies affirmed the hypertensive effects of cadmium (Cd) in humans. Nonetheless, conclusions between studies remain inconsistent. Objective: The aim of this study was to reevaluate the evidence for a potential relationship between Cd exposure and altered blood pressure and/or hypertension, focusing on studies published between January 2010 and March 2020.
   Methods: We reviewed all observational studies from database searches (PubMed and SCOPUS) on Cd exposure and blood pressure or hypertension. We extracted information from studies that provided sufficient data on population characteristics, smoking status, exposure, outcomes, and design.
   Results: Thirty-eight studies met our inclusion criteria; of those, twenty-nine were cross sectional, three case control, five cohort and one interventional study. Blood or urinary Cd levels were the most commonly used biomarkers.
   Conclusions: A positive association between blood Cd levels and blood pressure and/or hypertension was identified in numerous studies at different settings. Limited number of representative population-based studies of never-smokers was observed, which may have confounded our conclusions. The association between urinary Cd and blood pressure and/or hypertension remains uncertain due to conflicting results, including inverse relationships with lack of strong mechanistic support. We point to the urgent need for additional longitudinal studies to confirm our findings.
C1 [Martins, Airton C.; Aschner, Michael; Paoliello, Monica M. B.] Albert Einstein Coll Med, Dept Mol Pharmacol, 1300 Morris Pk Ave, Bronx, NY 10461 USA.
   [Almeida Lopes, Ana Carolina B.; Silva, Ana Maria R.; Paoliello, Monica M. B.] Univ Estadual Londrina, Ctr Hlth Sci, Grad Program Publ Hlth, 60 Robert Koch Ave, BR-86038350 Londrina, PR, Brazil.
   [Urbano, Mariana R.] Univ Estadual Londrina, Dept Stat, Rodovia Celso Garcia Cid,Km 380,S-no,Campus Univ, BR-86057970 Londrina, PR, Brazil.
   [Carvalho, Maria de Fatima H.] Adolfo Lutz Inst, Inorgan Contaminants Dept, Ave Doutor Arnaldo,355, BR-01246000 Sao Paulo, SP, Brazil.
   [Tinkov, Alexey A.; Aschner, Michael] IM Sechenov First Moscow Med Univ, Sechenov Univ, Bolshaya Pirogovskaya St,19-1, Moscow 119146, Russia.
   [Tinkov, Alexey A.] Yaroslavl State Univ, Yaroslavl 150000, Russia.
   [Mesas, Arthur E.] Univ Castilla La Mancha, Fac Enfermeria, Edificio Melchor Cano,Campus Univ Cuenca, Cuenca 16071, Spain.
   [Silbergeld, Ellen K.] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, 615N Wolfe St, Baltimore, MD 21205 USA.
C3 Yeshiva University; Montefiore Medical Center; Albert Einstein College
   of Medicine; Universidade Estadual de Londrina; Universidade Estadual de
   Londrina; Instituto Adolfo Lutz; Sechenov First Moscow State Medical
   University; Yaroslavl State University; Universidad de Castilla-La
   Mancha; Johns Hopkins University; Johns Hopkins Bloomberg School of
   Public Health
RP Paoliello, MMB (corresponding author), Albert Einstein Coll Med, Dept Mol Pharmacol, 1300 Morris Pk Ave, Bronx, NY 10461 USA.
EM monica.paoliello@einsteinmed.org
RI Venancio Lopes, Ana Carolina/AAX-4000-2021; Tinkov, Alexey/H-5842-2016;
   Urbano, Mariana/AAQ-5622-2021; Aschner, Michael/ACO-6461-2022; Mesas,
   Arthur/AAK-3361-2021; Martins, Airton/I-8463-2017
OI Mesas, Arthur/0000-0002-0088-8607; Urbano, Mariana/0000-0002-5411-5554
FU National Institute of Environmental Health Sciences (NIEHS) [R01ES07331,
   R01ES10563]
FX MA was supported in part by grants from the National Institute of
   Environmental Health Sciences (NIEHS) R01ES07331 and R01ES10563.
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NR 105
TC 37
Z9 41
U1 4
U2 16
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0147-6513
EI 1090-2414
J9 ECOTOX ENVIRON SAFE
JI Ecotox. Environ. Safe.
PD JAN 15
PY 2021
VL 208
AR 111636
DI 10.1016/j.ecoenv.2020.111636
PG 18
WC Environmental Sciences; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Toxicology
GA PM9WG
UT WOS:000604139300013
PM 33396156
OA gold, Green Accepted
DA 2025-06-11
ER

PT J
AU Soliman, AF
   Abdel-Rahman, MA
   Elsayed, HH
   Eltamany, EH
   Al-Sherbini, A
AF Soliman, Amira F.
   Abdel-Rahman, Mohamed A.
   Elsayed, Hanaa H.
   Eltamany, Elsayed H.
   Al-Sherbini, Al-Sayed
TI Blending and Characterization of Gold Nanoparticles with Omega-3 Oils
   Induces Antidiabetic, and Antioxidant Activities in-vivo
SO EGYPTIAN JOURNAL OF CHEMISTRY
LA English
DT Article
DE Diabetes; Liver; Omega-3 oils; Gold nanoparticles
ID INDUCED INSULIN-RESISTANCE; INDUCED LIVER-INJURY; OXIDATIVE STRESS;
   FLAXSEED OIL; FATTY-ACIDS; METABOLIC SYNDROME; HEPATIC STEATOSIS;
   LIPID-METABOLISM; FRUCTOSE; SUPPLEMENTATION
AB THE aim of the study is to explore the antidiabetic and antioxidant activities of gold nanoparticles (AuNPs) mixed with either flaxseed oil (FLO) or fish oil (FIO). A pyrolysis method was used to prepare AuNPs in oleic acid. The characteristics of the sample were determined by using the transmission electron microscope (TEM) and UV spectroscopy. Male albino rats were divided into two main groups. Group one (n=10 rats) was fed on the basic diet (serves as healthy control). The other group was fed on the high fructose diet (HFD) for four weeks and then was divided into five subgroups. 1st subgroup was fed on HFD only, 2nd and 4th subgroups were fed on HID mixed with omega-3 oils while 3rd and 5th fed on HID+ omega-3 oils mixed with AuNPs. Results revealed that there was a significant decrease in glucose level, serum insulin, homeostasis model assessment of insulin resistance (HOMA-IR) index and lipid peroxidation in oils nanoparticles treated groups compared to the HFD group and a significant increase in the homeostasis model assessment of beta-cell function (HOMA-beta) and Glutathione (GSH). It can be concluded that AuNPs mixed omega-3 oils have more anti-diabetic, hepatic protection and antioxidant properties than omega-3 oils alone.
C1 [Soliman, Amira F.; Elsayed, Hanaa H.] Natl Nutr Inst NNI Hlth Minster, Dept Nutrit Chem & Metab, Cairo, Egypt.
   [Abdel-Rahman, Mohamed A.] Suez Canal Univ, Fac Sci, Zool Dept, Ismailia, Egypt.
   [Eltamany, Elsayed H.] Suez Canal Univ, Fac Sci, Chem Dept, Ismailia, Egypt.
   [Al-Sherbini, Al-Sayed] Cairo Univ, Natl Inst Laser Enhanced Sci NILES, Dept Measurements Photochem & Agr Applicat, Giza, Egypt.
C3 Egyptian Knowledge Bank (EKB); Suez Canal University; Egyptian Knowledge
   Bank (EKB); Suez Canal University; Egyptian Knowledge Bank (EKB); Cairo
   University
RP Soliman, AF (corresponding author), Natl Nutr Inst NNI Hlth Minster, Dept Nutrit Chem & Metab, Cairo, Egypt.; Abdel-Rahman, MA (corresponding author), Suez Canal Univ, Fac Sci, Zool Dept, Ismailia, Egypt.
EM amira_fawzy2013@yahoo.com; mohamed_hassanain@science.suez.edu.eg
RI Abdel-Rahman, Mohamed/L-8362-2013
OI Soliman, Amira Fawzy/0000-0003-2361-4235; Eltamany,
   Elsayed/0000-0002-9210-1647
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NR 72
TC 4
Z9 4
U1 0
U2 8
PU NATL INFORM & DOCUMENT CENTRE
PI CAIRO
PA NIDOC DOKKI, CAIRO, 00000, EGYPT
SN 0449-2285
EI 2357-0245
J9 EGYPT J CHEM
JI Egypt. J. Chem.
PD JUL
PY 2020
VL 63
IS 7
BP 2419
EP 2433
DI 10.21608/ejchem.2019.18861.2159
PG 15
WC Chemistry, Multidisciplinary
WE Emerging Sources Citation Index (ESCI)
SC Chemistry
GA NZ5MG
UT WOS:000577146600002
OA Bronze
DA 2025-06-11
ER

PT J
AU Moraes, IAP
   Silva, TD
   Massetti, T
   Menezes, LDC
   Ribeiro, VF
   Tropiano, LMCC
   Barnabé, V
   Hoshi, RA
   Monteiro, CBM
   Fernandes, M
AF Moraes, Ibis A. P.
   Silva, Talita D.
   Massetti, Thais
   Menezes, Lilian D. C.
   Ribeiro, Vivian F.
   Tropiano, Ligia M. C. C.
   Barnabe, Viviani
   Hoshi, Rosangela A.
   Monteiro, Carlos B. M.
   Fernandes, Marcelo
TI Fractal correlations and linear analyses of heart rate variability in
   healthy young people with different levels of physical activity
SO CARDIOLOGY IN THE YOUNG
LA English
DT Article
DE Autonomic nervous system; heart rate; sympathetic nervous system
ID CARDIAC AUTONOMIC MODULATION; NONLINEAR-ANALYSIS; SYMBOLIC ANALYSIS;
   EXERCISE; SYSTEM; COMPLEXITY; COMPONENTS; INTENSITY; CHILDREN; RECOVERY
AB Changes in cardiac autonomic regulation, expressed by increased sympathetic activity and decreased heart rate variability, have an important relationship with the onset of lethal cardiac phenomena. Therefore, we aimed to evaluate the cardiac autonomic behaviour in young people according to their level of physical activity. Through the International Physical Activity Questionnaire, 55 healthy young non-smokers with no history of previous diseases and whose parents did not suffer from metabolic syndrome were assessed and divided into groups: sedentary (n=12), insufficiently active (n=16), active (n=14), and very active (n=13). We collected respiratory rate, systolic and diastolic blood pressure at rest, and body mass index. Subjects remained supine at rest, and without mental stress for 15 minutes in a controlled environment. Using a cardio frequency meter (Polar (R) RS800CX), data were analysed in the time domain, frequency domain, and detrended fluctuation analysis. For the sedentary group, the mean RR and rMSSD were significantly lower, and the insufficiently active group showed higher means, but significantly only for rMSSD. The insufficiently active group showed in the detrended fluctuation analysis that alpha 2 was significantly lower compared with the sedentary, active, and very active groups. We conclude that young, healthy, sedentary individuals present an increased heart rate and that insufficiently active individuals present a decreased fractal correlation and increased parasympathetic activity.
C1 [Moraes, Ibis A. P.; Silva, Talita D.; Massetti, Thais; Monteiro, Carlos B. M.] Univ Sao Paulo, Sch Med, Grad Program Rehabil Sci, Sao Paulo, Brazil.
   [Moraes, Ibis A. P.; Tropiano, Ligia M. C. C.; Fernandes, Marcelo] Univ Prebiteriana Mackenzie, Dept Phys Therapy, Sao Paulo, Brazil.
   [Silva, Talita D.; Menezes, Lilian D. C.; Ribeiro, Vivian F.] Fed Univ Sao Paulo UNIFESP, Dept Cardiol, Sao Paulo, Brazil.
   [Barnabe, Viviani] Univ City Sao Paulo UNICID, Med Sch, Sao Paulo, Brazil.
   [Hoshi, Rosangela A.] Univ Sao Paulo, Univ Hosp, Sao Paulo, Brazil.
C3 Universidade de Sao Paulo; Universidade Presbiteriana Mackenzie;
   Universidade Federal de Sao Paulo (UNIFESP); Universidade Cidade de Sao
   Paulo; Universidade de Sao Paulo
RP Moraes, IAP (corresponding author), Univ Sao Paulo, Fac Med, Cipotanea 51,Cidade Univ, BR-05360160 Sao Paulo, SP, Brazil.
EM ibisariana@yahoo.com.br
RI Hoshi, Rosangela/H-5589-2015; Moraes, Íbis/IUM-1940-2023; Ribeiro,
   Vivian/AAD-6172-2021; Massetti, Thais/W-1111-2018; Bandeira de Mello
   Monteiro, Carlos/P-2474-2016; Dias da Silva-Magalhaes,
   Talita/F-6519-2012
OI Bandeira de Mello Monteiro, Carlos/0000-0002-2661-775X; Moraes,
   Ibis/0000-0002-1672-2628; Dias da Silva-Magalhaes,
   Talita/0000-0002-4683-4671
FU Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior -Brasil
   [001]
FX This study was financed in part by the Coordenacao de Aperfeicoamento de
   Pessoal de Nivel Superior -Brasil: Finance Code 001.
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NR 59
TC 13
Z9 13
U1 1
U2 13
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 1047-9511
EI 1467-1107
J9 CARDIOL YOUNG
JI Cardiol. Young
PD OCT
PY 2019
VL 29
IS 10
BP 1236
EP 1242
DI 10.1017/S1047951119001793
PG 7
WC Cardiac & Cardiovascular Systems; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Pediatrics
GA KI2WQ
UT WOS:000511211500003
PM 31475643
DA 2025-06-11
ER

PT J
AU Salimi, Y
   Taghdir, M
   Sepandi, M
   Zarchi, AAK
AF Salimi, Yahya
   Taghdir, Maryam
   Sepandi, Mojtaba
   Zarchi, Ali-Akbar Karimi
TI The prevalence of overweight and obesity among Iranian military
   personnel: a systematic review and meta-analysis
SO BMC PUBLIC HEALTH
LA English
DT Review
DE Prevalence; Overweight; Obesity; Systematic review; Meta-analysis;
   Military personnel
ID BODY-MASS INDEX; METABOLIC SYNDROME; PHYSICAL-ACTIVITY; ASSOCIATION;
   TRENDS; WORKERS; STRESS; WEIGHT; DISORDERS; MORTALITY
AB Background: The overweight and obesity among military personnel, as an occupational group, beside the health issues, might affect their military performance. A systematic review and meta-analysis were conducted to estimate the pool prevalence of overweight and obesity among Iranian military personnel.
   Methods: The national databases including Science Information Database, MagIran, and the following international databases; Web of Science, Medline via PubMed, and Scopus were searched, up to December 2017, for relevant published studies without time limitation.
   Results: Totally, 1431 studies were reterived and 10 studies included in meta-analysis. The pooled prevalence of overweight and obesity were 41% (95% CI: 26, 57%) and 13% (95% CI: 10, 17%), respectively. In the subgroup analyses, a lower and higher prevalence of overweight was reported in the ground (12%) and Navy (69%) forces military, recpectively. For the obesity, the air forces had the lowest prevalence (11%) and the ground and Navy forces military had highest prevalence (15%). The prevalence of overweight and obesity were slightly higher in studies conducted after 2014.
   Conclusion: Our findings suggest a high prevalence of overweight and obesity in the military personnel as a high-risk occupational group. Owing to the high observed heterogeneity among the included studies, large representative studies are needed to estimate the prevalence of overweight and obesity in the military personnel.
C1 [Salimi, Yahya; Taghdir, Maryam; Sepandi, Mojtaba; Zarchi, Ali-Akbar Karimi] Baqiyatallah Univ Med Sci, Life Style Inst, Hlth Res Ctr, Tehran, Iran.
   [Taghdir, Maryam] Baqiyatallah Univ Med Sci, Fac Hlth, Dept Nutr & Food Hyg, Tehran, Iran.
   [Sepandi, Mojtaba; Zarchi, Ali-Akbar Karimi] Baqiyatallah Univ Med Sci, Fac Hlth, Dept Epidemiol & Biostat, Tehran, Iran.
C3 Baqiyatallah University of Medical Sciences (BMSU); Baqiyatallah
   University of Medical Sciences (BMSU); Baqiyatallah University of
   Medical Sciences (BMSU)
RP Taghdir, M; Sepandi, M (corresponding author), Baqiyatallah Univ Med Sci, Life Style Inst, Hlth Res Ctr, Tehran, Iran.
EM mtaghdir@gmail.com; msepandi@gmail.com
RI Karimizarchi, aliakbar/R-4117-2019; Sepandi, Mojtaba/I-8561-2014;
   Taghdir, Maryam/U-3122-2018
OI , ali akbar/0000-0001-5138-8605
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NR 60
TC 29
Z9 30
U1 0
U2 4
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2458
J9 BMC PUBLIC HEALTH
JI BMC Public Health
PD FEB 6
PY 2019
VL 19
AR 162
DI 10.1186/s12889-019-6484-z
PG 9
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA HM8EF
UT WOS:000459710500001
PM 30727986
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Kumar, P
   Efstathopoulos, P
   Millischer, V
   Olsson, E
   Wei, YB
   Brüstle, O
   Schalling, M
   Villaescusa, JC
   Ösby, U
   Lavebratt, C
AF Kumar, Parvin
   Efstathopoulos, Paschalis
   Millischer, Vincent
   Olsson, Eric
   Wei, Ya Bin
   Bruestle, Oliver
   Schalling, Martin
   Villaescusa, J. Carlos
   Osby, Urban
   Lavebratt, Catharina
TI Mitochondrial DNA copy number is associated with psychosis severity and
   anti-psychotic treatment
SO SCIENTIFIC REPORTS
LA English
DT Article
ID AGE-RELATED DECLINE; BIPOLAR DISORDER; OXIDATIVE STRESS; TELOMERE
   LENGTH; METABOLIC SYNDROME; ATYPICAL ANTIPSYCHOTICS;
   PSYCHIATRIC-DISORDERS; SCHIZOPHRENIA; DYSFUNCTION; BLOOD
AB Mitochondrial pathology has been implicated in the pathogenesis of psychotic disorders. A few studies have proposed reduced leukocyte mitochondrial DNA (mtDNA) copy number in schizophrenia and bipolar disorder type I, compared to healthy controls. However, it is unknown if mtDNA copy number alteration is driven by psychosis, comorbidity or treatment. Whole blood mtDNA copy number was determined in 594 psychosis patients and corrected for platelet to leukocyte count ratio (mtDNAcn(res)). The dependence of mtDNAcnres on clinical profile, metabolic comorbidity and antipsychotic drug exposure was assessed. mtDNAcnres was reduced with age (beta = -0.210, p < 0.001), use of clozapine (beta = -0.110, p = 0.012) and risperidone (beta = -0.109, p = 0.014), dependent on prescribed dosage (p = 0.006 and p = 0.026, respectively), and the proportion of life on treatment (p = 0.006). Clozapine (p = 0.0005) and risperidone (p = 0.0126) had a reducing effect on the mtDNA copy number also in stem cell-derived human neurons in vitro at therapeutic plasma levels. For patients not on these drugs, psychosis severity had an effect (beta = -0.129, p = 0.017), similar to age (beta = -0.159, p = 0.003) and LDL (beta = -0.119, p = 0.029) on whole blood mtDNAcnres. Further research is required to determine if mtDNAcnres reflects any psychosis-intrinsic mitochondrial changes.
C1 [Kumar, Parvin; Efstathopoulos, Paschalis; Millischer, Vincent; Wei, Ya Bin; Schalling, Martin; Villaescusa, J. Carlos; Lavebratt, Catharina] Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden.
   [Kumar, Parvin; Efstathopoulos, Paschalis; Millischer, Vincent; Wei, Ya Bin; Schalling, Martin; Villaescusa, J. Carlos; Osby, Urban; Lavebratt, Catharina] Karolinska Univ Hosp, Ctr Mol Med, Stockholm, Sweden.
   [Olsson, Eric; Osby, Urban] PRIMA Child & Adult Psychiat AB, Dept Adult Psychiat, Stockholm, Sweden.
   [Olsson, Eric; Osby, Urban] Karolinska Inst, Dept Neurobiol Care Sci & Soc, Stockholm, Sweden.
   [Wei, Ya Bin] Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA.
   [Bruestle, Oliver] Univ Bonn, Inst Reconstruct Neurobiol, Med Fac, Bonn, Germany.
C3 Karolinska Institutet; Karolinska Institutet; Karolinska University
   Hospital; Karolinska Institutet; University of California System;
   University of California San Diego; University of Bonn
RP Kumar, P; Lavebratt, C (corresponding author), Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden.; Kumar, P; Lavebratt, C (corresponding author), Karolinska Univ Hosp, Ctr Mol Med, Stockholm, Sweden.
EM parvin.kumar@ki.se; Catharina.lavebratt@ki.se
RI Schalling, Martin/F-1518-2015; Millischer, Vincent/AAI-6800-2020;
   Olsson, Eric/E-2815-2017
OI Kumar, Parvin/0000-0003-2324-4465; Lavebratt,
   Catharina/0000-0003-4987-2718; Millischer, Vincent/0000-0003-1919-9649
FU Stockholm County Council; Karolinska Institutet, by the
   Soderstrom-Konigska Foundation
FX We are grateful to all patients and research assistant Carina Schmidt.
   The study was financially supported by a regional accord on medical
   training and clinical research between Stockholm County Council and
   Karolinska Institutet, by the Soderstrom-Konigska Foundation. In
   addition we thank the Swedish Brain Foundation, the Swedish Research
   Council and the Regional Drug and Therapeutic Committee in Stockholm
   (Laksak).
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NR 115
TC 38
Z9 38
U1 0
U2 9
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD AUG 24
PY 2018
VL 8
AR 12743
DI 10.1038/s41598-018-31122-0
PG 13
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Science & Technology - Other Topics
GA GR4SF
UT WOS:000442606500030
PM 30143692
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Narayanankutty, A
   Manalil, JJ
   Suseela, IM
   Ramavarma, SK
   Mathew, SE
   Illam, SP
   Babu, TD
   Kuzhivelil, BT
   Raghavamenon, AC
AF Narayanankutty, A.
   Manalil, J. J.
   Suseela, I. M.
   Ramavarma, S. K.
   Mathew, S. E.
   Illam, S. P.
   Babu, T. D.
   Kuzhivelil, B. T.
   Raghavamenon, A. C.
TI Deep fried edible oils disturb hepatic redox equilibrium and heightens
   lipotoxicity and hepatosteatosis in male Wistar rats
SO HUMAN & EXPERIMENTAL TOXICOLOGY
LA English
DT Article
DE Coconut oil; dyslipidemia; hepatosteatosis; high fructose diet; mustard
   oil; thermal oxidation
ID FATTY LIVER-DISEASE; INDUCED INSULIN-RESISTANCE; MUSTARD OIL; COCONUT
   OIL; NONALCOHOLIC STEATOHEPATITIS; LIPID-PEROXIDATION; METABOLIC
   SYNDROME; SUNFLOWER OIL; CONSUMPTION; DYSLIPIDEMIA
AB Hepatosteatosis is a complex disorder, in which insulin resistance and associated dyslipidemic and inflammatory conditions are fundamental. Dietary habit, especially regular consumption of fat and sugar-rich diet, is an important risk factor. Coconut and mustard oils (CO and MO) are medium-chain saturated and monounsaturated fats that are common dietary ingredients among the Indian populations. Present study analyzed the effect of prolonged consumption of the fresh and thermally oxidized forms of these oils on glucose tolerance and hepatosteatosis in male Wistar rats. Thermally oxidized CO (TCO) and MO (TMO) possessed higher amount of lipid peroxidation products and elevated p-anisidine values than their fresh forms. Dietary administration of TCO and TMO along with fructose altered glucose tolerance and increased hyperglycemia in rats. Dyslipidemia was evident by elevated levels of triglycerides and reduced high density lipoprotein cholesterol (HDLc) levels in fructose and edible oil-fed group (p < 0.05). Additionally, hepatic antioxidant status was diminished and oxidative stress markers were elevated in TCO- and TMO-fed rats. Substantiating these, hike in liver function marker enzyme activities were also observed in these animals. Supporting this, histological analysis revealed higher incidence of microvesicles and hepatocellular ballooning. Results thus suggest that consumption of thermally oxidized fats may cause hepatic damage.
C1 [Narayanankutty, A.; Manalil, J. J.; Suseela, I. M.; Ramavarma, S. K.; Mathew, S. E.; Illam, S. P.; Babu, T. D.; Raghavamenon, A. C.] Univ Calicut, Recognized Ctr, Amala Canc Res Ctr, Trichur, Kerala, India.
   [Kuzhivelil, B. T.] Univ Calicut, Dept Zool, Christ Coll, Appl Biochem & Biotechnol Lab, Thenhipalam, Kerala, India.
C3 University of Calicut; University of Calicut
RP Raghavamenon, AC (corresponding author), Amala Canc Res Ctr, Trichur 680555, Kerala, India.
EM raghav@amalaims.org
RI DEVASSY, BABU/S-9087-2017; Raghavamenon, Achuthan/N-1921-2019;
   Kuzhivelil, Balu/O-5773-2018; Illam, Soorya/AAB-2887-2019;
   Narayanankutty, Arunaksharan/D-7288-2015; Parathodi Illam,
   Soorya/I-9622-2016; MATHEW, SHAJI/K-6416-2016
OI Narayanankutty, Arunaksharan/0000-0002-6232-1665; Parathodi Illam,
   Soorya/0000-0003-0890-0137; Kuzhivelil, Balu T./0000-0001-7970-0023;
   MATHEW, SHAJI/0000-0002-5662-7262
FU Council of Scientific and Industrial Research, India [09/869
   (0012)/2012-EMR-I]
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: This work
   was supported by the Council of Scientific and Industrial Research,
   India, in the form of Junior Research Fellowship (09/869
   (0012)/2012-EMR-I).
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NR 52
TC 23
Z9 25
U1 0
U2 17
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0960-3271
EI 1477-0903
J9 HUM EXP TOXICOL
JI Hum. Exp. Toxicol.
PD SEP
PY 2017
VL 36
IS 9
BP 919
EP 930
DI 10.1177/0960327116674530
PG 12
WC Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Toxicology
GA FE7MR
UT WOS:000408391700005
PM 28466662
DA 2025-06-11
ER

PT J
AU Atek-Mebarki, F
   Hichami, A
   Abdoul-Azize, S
   Bitam, A
   Koceïr, EA
   Khan, NA
AF Atek-Mebarki, Feriel
   Hichami, Aziz
   Abdoul-Azize, Souleymane
   Bitam, Arezki
   Koceir, Elhadj Ahmed
   Khan, Naim Akhtar
TI Eicosapentaenoic acid modulates fatty acid metabolism and inflammation
   in Psammomys obesus
SO BIOCHIMIE
LA English
DT Article
DE Liver; Adipose tissue; Inflammation; Lipid; Obesity; Psammomys obesus
ID INSULIN-RESISTANCE; OXIDATIVE STRESS; SAND RAT; OBESITY; LIVER;
   OMEGA-3-FATTY-ACIDS; LIPOPROTEIN; LIPOGENESIS; INHIBITION; EXPRESSION
AB The desert gerbil, Psammomys obesus, is a unique polygenic animal model of metabolic syndrome (insulin resistance, obesity and type 2 diabetes), and these pathological conditions resemble to those in human beings. In this study, the animals were fed ad libitum either a natural diet (ND) which contained desertic halophile plants or a standard laboratory diet (STD) or a diet which contained eicosapentaenoic acid (EPA), hence, termed as EPA diet (EPAD). In EPAD, 50% of total lipid content was replaced by EPA oil. By employing real-time PCR, we assessed liver expression of key genes involved in fatty acid metabolism such as PPAR-alpha, SREBP-1c, LXR-alpha and CHREBP. We also studied the expression of two inflammatory genes, i.e., TNF-alpha and IL-1 beta, in liver and adipose tissue of these animals. The STD, considered to be a high caloric diet for this animal, triggered insulin resistance and high lipid levels, along with high hepatic SREBP-1c, LXR-alpha and CHREBP mRNA expression. TNF-alpha and IL-1 beta mRNA were also high in liver of STD fed animals. Feeding EPAD improved plasma glucose, insulin and triacylglycerol levels along with hepatic lipid composition. These observations suggest that EPA exerts beneficial effects in P. obesus. (C) 2014 Elsevier B.V. and Societe Francaise de Biochimie et Biologie Moleculaire (SFBBM). All rights reserved.
C1 [Atek-Mebarki, Feriel; Hichami, Aziz; Abdoul-Azize, Souleymane; Khan, Naim Akhtar] Univ Bourgogne, INSERM, UMR U866, Agro Sup, F-21000 Dijon, France.
   [Atek-Mebarki, Feriel; Bitam, Arezki; Koceir, Elhadj Ahmed] Univ Sci & Technol Houari Boumed, Biol Sci & Physiol Dept, FSB, Bioenerget & Intermediary Metab Lab, Algiers, Algeria.
C3 Institut National de la Sante et de la Recherche Medicale (Inserm);
   Institut Agro; AgroSup Dijon; Universite Bourgogne Europe; University
   Science & Technology Houari Boumediene
RP Khan, NA (corresponding author), UMR U866 INSERM, 6 Blvd Gabriel, F-21000 Dijon, France.
EM Naim.Khan@u-bourgogne.fr
RI Hichami, Aziz/MCJ-2247-2025; Abdoul-Azize, Souleymane/AAB-2181-2021
OI hichami, aziz/0000-0003-4331-5152; KOCEIR,
   Elhadj-Ahmed/0000-0003-1345-2535; Abdoul-Azize,
   Souleymane/0000-0003-2065-9091
FU Ministry for External Affairs, France via a Franco-Algerian
   collaborative project "Tassili" [12MDU855]
FX We are thankful to the Ministry for External Affairs, France, for the
   sanction of a contingent grant and a scholarship (to FAM) via a
   Franco-Algerian collaborative project "Tassili" (grant number 12MDU855).
   The funders had no role in study design, data collection and analysis,
   decision to publish, or preparation of the manuscript.
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NR 31
TC 3
Z9 3
U1 0
U2 14
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0300-9084
EI 1638-6183
J9 BIOCHIMIE
JI Biochimie
PD FEB
PY 2015
VL 109
BP 60
EP 66
DI 10.1016/j.biochi.2014.12.004
PG 7
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA CB3AQ
UT WOS:000349500500007
PM 25528298
DA 2025-06-11
ER

PT J
AU Kopf, T
   Schaefer, HL
   Troetzmueller, M
   Koefeler, H
   Broenstrup, M
   Konovalova, T
   Schmitz, G
AF Kopf, Thomas
   Schaefer, Hans-Ludwig
   Troetzmueller, Martin
   Koefeler, Harald
   Broenstrup, Mark
   Konovalova, Tatiana
   Schmitz, Gerd
TI Influence of Fenofibrate Treatment on Triacylglycerides,
   Diacylglycerides and Fatty Acids in Fructose Fed Rats
SO PLOS ONE
LA English
DT Article
ID STEAROYL-COA DESATURASE-1; ACTIVATED RECEPTOR-ALPHA; PPAR-ALPHA;
   GENE-EXPRESSION; OXIDATIVE STRESS; INSULIN-RESISTANCE; METABOLIC
   SYNDROME; DIABETES-MELLITUS; ENERGY-METABOLISM; LIPID EXTRACTION
AB Fenofibrate (FF) lowers plasma triglycerides via PPAR alpha activation. Here, we analyzed lipidomic changes upon FF treatment of fructose fed rats. Three groups with 6 animals each were defined as control, fructose-fed and fructose-fed/FF treated. Male Wistar Unilever Rats were subjected to 10% fructose-feeding for 20 days. On day 14, fenofibrate treatment (100 mg/kg p.o.) was initiated and maintained for 7 days. Lipid species in serum were analyzed using mass spectrometry (ESI-MS/MS; LCFT-MS, GC-MS) on days 0, 14 and 20 in all three groups. In addition, lipid levels in liver and intestine were determined. Shortchain TAGs increased in serum and liver upon fructose-feeding, while almost all TAG-species decreased under FF treatment. Long-chain unsaturated DAG-levels (36: 1, 36: 2, 36: 4, 38: 3, 38: 4, 38: 5) increased upon FF treatment in rat liver and decreased in rat serum. FAs, especially short-chain FAs (12: 0, 14: 0, 16: 0) increased during fructose-challenge. VLDL secretion increased upon fructose-feeding and together with FA-levels decreased to control levels during FF treatment. Fructose challenge of de novo fatty acid synthesis through fatty acid synthase (FAS) may enhance the release of FAs <= 16: 0 chain length, a process reversed by FF-mediated PPAR alpha-activation.
C1 [Kopf, Thomas; Konovalova, Tatiana; Schmitz, Gerd] Univ Hosp Regensburg, Inst Clin Chem & Lab Med, Regensburg, Germany.
   [Schaefer, Hans-Ludwig; Broenstrup, Mark] Sanofi Aventis Germany, R&D DIAB Div, Biomarker & Diagnost, Frankfurt, Germany.
   [Troetzmueller, Martin; Koefeler, Harald] Med Univ Graz, ZMF, Core Facil Mass Spectrometry, Graz, Austria.
C3 University of Regensburg; Sanofi-Aventis; Sanofi Germany; Medical
   University of Graz
RP Schmitz, G (corresponding author), Univ Hosp Regensburg, Inst Clin Chem & Lab Med, Regensburg, Germany.
EM gerd.schmitz@klinik.uni-regensburg.de
RI Brönstrup, Mark/AAP-7598-2020
OI Schmitz, Gerd/0000-0002-1325-1007; Bronstrup, Mark/0000-0002-8971-7045;
   Kofeler, Harald/0000-0002-2725-9616
FU European Community [202272]; IP-Project LipidomicNet; BMBF ("SysMBo")
   [0315494C]
FX This work was supported by the European Community's Seventh Framework
   Programme (FP7/2007-2013) under grant agreement no 202272, IP-Project
   LipidomicNet and BMBF ("SysMBo," sponsorship number 0315494C). The
   funders had no role in study design, data collection and analysis,
   decision to publish, or preparation of the manuscript.
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NR 46
TC 19
Z9 20
U1 0
U2 17
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD SEP 8
PY 2014
VL 9
IS 9
AR e106849
DI 10.1371/journal.pone.0106849
PG 11
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA AO4JX
UT WOS:000341304700060
PM 25198467
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU d'Ettorre, G
   Francone, M
   Mancone, M
   Ceccarelli, G
   Ascarelli, A
   Vullo, F
   Baroncelli, S
   Galluzzo, MC
   Catalano, C
   Strano, S
   Fedele, F
   Mastroianni, C
   Palmisano, L
   Vullo, V
AF d'Ettorre, Gabriella
   Francone, Marco
   Mancone, Massimo
   Ceccarelli, Giancarlo
   Ascarelli, Adriano
   Vullo, Francesco
   Baroncelli, Silvia
   Galluzzo, M. Clementina
   Catalano, Carlo
   Strano, Stefano
   Fedele, Francesco
   Mastroianni, Claudio
   Palmisano, Lucia
   Vullo, Vincenzo
TI Significant coronary stenosis detected by coronary computed angiography
   in asymptomatic HIV infected subjects
SO JOURNAL OF INFECTION
LA English
DT Article
DE HIV; Heart; CT scan
ID AMERICAN-HEART-ASSOCIATION; INTIMA-MEDIA THICKNESS; RECEIVING
   ANTIRETROVIRAL THERAPY; C-REACTIVE PROTEIN; DUAL-SOURCE CT;
   APPROPRIATENESS CRITERIA; MAGNETIC-RESONANCE; SUBCLINICAL
   ATHEROSCLEROSIS; INTRAVASCULAR ULTRASOUND; TOMOGRAPHY ANGIOGRAPHY
AB Objectives: increased incidence of acute coronary events, high rate of abnormal surrogate markers of atherosclerosis and increased amount of coronary calcium have been described in HIV infected population.
   To expand knowledge on coronary artery disease (CAD) in HIV patients, cardiac CT scan was performed in asymptomatic subjects with low cardiovascular (CV) risk.
   Methods: A cross-sectional study using dual-source CT (MDCT) coronary angiography. was conducted in HIV-infected subjects with the following characteristics: Framingham Risk Score (FRS) <= 10, absence of metabolic syndrome, negative echocardiographic and ECG stress-test. A luminal narrowing exceeding 50% was defined as a clinically significant coronary stenosis.
   Calcium score was quantified using the Agatston Calcium Score method.
   Results: Fifty-five subjects were enrolled. Significant coronary stenoses, requiring coronary angiography, were found in 16/55 (29.1%). At multivariate analysis older age was the only variable independently associated with the presence of significant luminal narrowing (p = 0.011).
   Conclusions: MDCT showed an unexpected, age-associated high rate of significant coronary stenosis in asymptomatic HIV positive subjects with low CV risk. These findings suggest that aggressive screening programs for coronary artery disease may be appropriate in this population; further studies are recommended to assess the appropriateness of MDCT for this purpose. (C) 2011 The British Infection Association. Published by Elsevier Ltd. All rights reserved.
C1 [Baroncelli, Silvia; Galluzzo, M. Clementina; Palmisano, Lucia] Ist Super Sanita, Dept Therapeut Res & Med Evaluat, I-00161 Rome, Italy.
   [d'Ettorre, Gabriella; Ceccarelli, Giancarlo; Strano, Stefano; Mastroianni, Claudio; Vullo, Vincenzo] Univ Roma La Sapienza, Dept Publ Hlth & Infect Dis, Rome, Italy.
   [Francone, Marco; Ascarelli, Adriano; Vullo, Francesco; Catalano, Carlo] Univ Roma La Sapienza, Dept Radiol Sci, Rome, Italy.
   [Mancone, Massimo; Fedele, Francesco] Univ Roma La Sapienza, Dept Cardiovasc Resp Nephrol & Geriatr Sci, Rome, Italy.
C3 Istituto Superiore di Sanita (ISS); Sapienza University Rome; Sapienza
   University Rome; Sapienza University Rome
RP Palmisano, L (corresponding author), Ist Super Sanita, Dept Therapeut Res & Med Evaluat, Viale Regina Elena 299, I-00161 Rome, Italy.
EM l.palmisano@iss.it
RI Francone, Marco/AAQ-5434-2020; MASTROIANNI, Claudio/O-9741-2019;
   d'Ettorre, Gabriella/K-4511-2016; Fedele, Francesco/J-7651-2012; STRANO,
   Stefano/LEN-3279-2024; Malagnino, Vincenzo/HKM-4994-2023; galluzzo,
   clementina maria/M-8912-2017; Ceccarelli, Giancarlo/K-6454-2016;
   Francone, Marco/U-6761-2017
OI Baroncelli, Silvia/0000-0002-2050-9037; galluzzo, clementina
   maria/0000-0003-1392-6569; MASTROIANNI, Claudio
   Maria/0000-0002-1286-467X; d'Ettorre, Gabriella/0000-0002-3571-5677;
   Ceccarelli, Giancarlo/0000-0001-5921-3180; Francone,
   Marco/0000-0002-7906-3420; CATALANO, Carlo/0000-0003-4208-9691
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NR 32
TC 20
Z9 20
U1 0
U2 6
PU W B SAUNDERS CO LTD
PI LONDON
PA 32 JAMESTOWN RD, LONDON NW1 7BY, ENGLAND
SN 0163-4453
J9 J INFECTION
JI J. Infect.
PD JAN
PY 2012
VL 64
IS 1
BP 82
EP 88
DI 10.1016/j.jinf.2011.09.007
PG 7
WC Infectious Diseases
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases
GA 869YD
UT WOS:000298635400009
PM 21983631
OA Green Published
DA 2025-06-11
ER

PT J
AU Elshorbagy, AK
   Kozich, V
   Smith, AD
   Refsum, H
AF Elshorbagy, Amany K.
   Kozich, Viktor
   Smith, A. David
   Refsum, Helga
TI Cysteine and obesity: consistency of the evidence across epidemiologic,
   animal and cellular studies
SO CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE
LA English
DT Review
DE glutathione; H2O2; lipolysis; metabolic rate; redox state
ID GAMMA-GLUTAMYL-TRANSFERASE; Y GASTRIC BYPASS; HYDROGEN-SULFIDE;
   METHIONINE RESTRICTION; OXIDATIVE STRESS; PROTEIN-KINASE; AMINO-ACID;
   HORDALAND HOMOCYSTEINE; SUPPRESSES LIPOLYSIS; METABOLIC SYNDROME
AB Purpose of review
   The concentrations of several plasma amino acids increase in obesity. Notably, plasma total concentrations of the sulphur amino acid cysteine (tCys) are linearly associated with fat mass in large population studies. Animal and cellular experiments support the concept that cysteine may be obesogenic. Here we review experimental and epidemiologic findings linking cysteine and related compounds with fat regulation and obesity.
   Recent findings
   tCys, and to a lesser extent cystathionine, are the only plasma sulphur amino acids consistently associated with human obesity, whereas glutathione is inversely associated with BMI. Supplementing cyste(i) ne in rodents decreases energy expenditure and promotes adiposity, whereas defects of cysteine-synthesizing enzymes decrease body weight. In adipocytes, cysteine inhibits lipolysis and promotes lipogenesis via H2O2 production. Unlike most plasma amino acids, tCys levels do not decrease with gastric bypass-induced weight loss, further supporting the concept that elevated cysteine may be a cause, not a consequence of obesity. Although cysteine products (glutathione, taurine and H2S) are altered in obesity, they do not appear to explain cysteine's effects on body weight.
   Summary
   Cellular, animal and epidemiologic data are consistent with the view that cysteine is obesogenic. Targeted research linking in-vitro and in-vivo findings is needed to elucidate mechanisms involved.
C1 [Elshorbagy, Amany K.; Smith, A. David; Refsum, Helga] Univ Oxford, Dept Pharmacol, Mansfield Rd, Oxford OX1 3QT, England.
   [Elshorbagy, Amany K.] Univ Alexandria, Fac Med, Depart Dept Physiol, Alexandria, Egypt.
   [Kozich, Viktor] Charles Univ Prague, Fac Med 1, Inst Inherited Metab Disorders, Prague, Czech Republic.
   [Kozich, Viktor] Gen Univ Hosp, Prague, Czech Republic.
   [Refsum, Helga] Univ Oslo, Inst Basic Med Sci, Dept Nutr, Oslo, Norway.
C3 University of Oxford; Egyptian Knowledge Bank (EKB); Alexandria
   University; Charles University Prague; General University Hospital
   Prague; University of Oslo
RP Elshorbagy, AK (corresponding author), Univ Oxford, Dept Pharmacol, Mansfield Rd, Oxford OX1 3QT, England.
EM amany.elshorbagy@pharm.ox.ac.uk
RI Refsum, Helga/A-4073-2010; Elshorbagy, Amany/A-4117-2015; Kozich,
   Viktor/A-7672-2008; Smith, David/A-4233-2010
OI Elshorbagy, Amany/0000-0002-8624-860X; Kozich,
   Viktor/0000-0001-5820-5277; Smith, David/0000-0002-1095-6722
FU Norwegian Research Council; Charles Wolfson Charitable Trust; Ministry
   of Health of the Czech Republic [NS10036-4]; Ministry of Education of
   the Czech Republic [MSM0021620806]
FX The study was supported by the Norwegian Research Council and the
   Charles Wolfson Charitable Trust, and by grants from the Ministry of
   Health of the Czech Republic (No. NS10036-4) and Ministry of Education
   of the Czech Republic (No. MSM0021620806).
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NR 94
TC 93
Z9 99
U1 0
U2 13
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1363-1950
EI 1473-6519
J9 CURR OPIN CLIN NUTR
JI Curr. Opin. Clin. Nutr. Metab. Care
PD JAN
PY 2012
VL 15
IS 1
BP 49
EP 57
DI 10.1097/MCO.0b013e32834d199f
PG 9
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 863IA
UT WOS:000298154800008
PM 22108094
OA Bronze
DA 2025-06-11
ER

PT J
AU Sergi, D
   Melloni, M
   Passaro, A
   Neri, LM
AF Sergi, Domenico
   Melloni, Mattia
   Passaro, Angelina
   Neri, Luca Maria
TI Influence of Type 2 Diabetes and Adipose Tissue Dysfunction on Breast
   Cancer and Potential Benefits from Nutraceuticals Inducible in
   Microalgae
SO NUTRIENTS
LA English
DT Review
DE breast cancer; type 2 diabetes mellitus; insulin resistance; adipokines;
   microalgae; nutraceuticals
ID TUMOR-NECROSIS-FACTOR; GROWTH-FACTOR-I; INSULIN-RESISTANCE; HIGH
   GLUCOSE; TNF-ALPHA; MITOCHONDRIAL DYSFUNCTION; MACROPHAGE INFILTRATION;
   CLINICAL-RELEVANCE; METABOLIC SYNDROME; OXIDATIVE STRESS
AB Breast cancer (BC) represents the most prevalent cancer in women at any age after puberty. From a pathogenetic prospective, despite a wide array of risk factors being identified thus far, poor metabolic health is emerging as a putative risk factor for BC. In particular, type 2 diabetes mellitus (T2DM) provides a perfect example bridging the gap between poor metabolic health and BC risk. Indeed, T2DM is preceded by a status of hyperinsulinemia and is characterised by hyperglycaemia, with both factors representing potential contributors to BC onset and progression. Additionally, the aberrant secretome of the dysfunctional, hypertrophic adipocytes, typical of obesity, characterised by pro-inflammatory mediators, is a shared pathogenetic factor between T2DM and BC. In this review, we provide an overview on the effects of hyperglycaemia and hyperinsulinemia, hallmarks of type 2 diabetes mellitus, on breast cancer risk, progression, treatment and prognosis. Furthermore, we dissect the role of the adipose-tissue-secreted adipokines as additional players in the pathogenesis of BC. Finally, we focus on microalgae as a novel superfood and a source of nutraceuticals able to mitigate BC risk by improving metabolic health and targeting cellular pathways, which are disrupted in the context of T2DM and obesity.
C1 [Sergi, Domenico; Melloni, Mattia; Passaro, Angelina; Neri, Luca Maria] Univ Ferrara, Dept Translat Med, Via Luigi Borsari 46, I-44121 Ferrara, Italy.
   [Neri, Luca Maria] Univ Ferrara, Electron Microscopy Ctr, Lab Technol Adv Therapies LTTA, Via Luigi Borsari 46, I-44121 Ferrara, Italy.
C3 University of Ferrara; University of Ferrara
RP Passaro, A; Neri, LM (corresponding author), Univ Ferrara, Dept Translat Med, Via Luigi Borsari 46, I-44121 Ferrara, Italy.; Neri, LM (corresponding author), Univ Ferrara, Electron Microscopy Ctr, Lab Technol Adv Therapies LTTA, Via Luigi Borsari 46, I-44121 Ferrara, Italy.
EM domenico.sergi@unife.it; mattia.melloni@unife.it;
   angelina.passaro@unife.it; luca.neri@unife.it
RI Neri, Luca/J-2462-2017; Sergi, Domenico/Q-5585-2017; Passaro,
   Angelina/P-3401-2015
OI Melloni, Mattia/0000-0003-3987-7267; Sergi,
   Domenico/0000-0002-3001-410X; Neri, Luca Maria/0000-0002-7924-1477;
   Passaro, Angelina/0000-0001-8462-7000
FU University of Ferrara, Italy; LEGA ITALIANA PER LA LOTTA CONTRO I TUMORI
   (LILT, Ferrara) [C/A/0243/02/18]
FX This research was funded by Local Research grants from University of
   Ferrara, Italy (FAR 2022 and FAR 2023) to L.M.N. Moreover, this work was
   also supported with funding from the LEGA ITALIANA PER LA LOTTA CONTRO I
   TUMORI (LILT, Ferrara) (project number: C/A/0243/02/18).
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NR 252
TC 2
Z9 2
U1 1
U2 2
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD OCT
PY 2024
VL 16
IS 19
AR 3243
DI 10.3390/nu16193243
PG 24
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA I7O6V
UT WOS:001332119600001
PM 39408212
OA gold
DA 2025-06-11
ER

PT J
AU Koh, YC
   Pan, MH
AF Koh, Yen-Chun
   Pan, Min-Hsiung
TI Food-Borne Polycyclic Aromatic Hydrocarbons and Circadian Disruption
SO ACS OMEGA
LA English
DT Review
ID DNA ADDUCT FORMATION; METABOLIC SYNDROME; MAINSTREAM SMOKE; OXIDATIVE
   STRESS; LIPID-METABOLISM; MESSENGER-RNA; RECEPTOR; CLOCK; EXPRESSION;
   CYTOCHROME-P450
AB Circadian disruption has been found to increase the risk of metabolic diseases, brain disorders, and cancer. The aryl hydrocarbon receptor (AhR), responsible for xenobiotic metabolism, is known to be activated by certain environmental stimuli, including polycyclic aromatic hydrocarbons (PAHs). Exposure to these stimuli may lead to diseases related to circadian disruption, with AhR activation suggested as a leading cause. Both the aryl hydrocarbon receptor nuclear translocator (ARNT) and aryl hydrocarbon receptor nuclear translocator-like (BMAL1) are class II basic helix-loop-helix/Per-ARNT-SIM (bHLH-PAS) proteins. These proteins form heterodimers with stimulated class I bHLH-PAS proteins, including circadian locomotor output cycles kaput (CLOCK) and AhR. Due to their sequential similarity, the overactivation of AhR by toxicants, such as PAHs, may lead to the formation of heterodimers with BMAL1, potentially causing circadian disruption. Dysregulation of BMAL1 can affect a wide range of metabolic genes, emphasizing its crucial roles. However, this issue has not been adequately addressed. Previous studies have reported that the inhibitory effects of phytochemicals on AhR activation can ameliorate diseases induced by environmental toxicants. Additionally, some phytochemicals have shown preventive effects on circadian misalignment. Therefore, this Review aims to explore potential strategies to prevent circadian disruption induced by food-borne toxicants, such as benzo[a]pyrene; to generate new ideas for future studies; and to highlight the importance of investigating these preventive strategies.
C1 [Koh, Yen-Chun; Pan, Min-Hsiung] Natl Taiwan Univ, Inst Food Sci & Technol, Taipei 106017, Taiwan.
   [Pan, Min-Hsiung] China Med Univ, China Med Univ Hosp, Dept Med Res, Taichung 404327, Taiwan.
   [Pan, Min-Hsiung] Asia Univ, Dept Hlth & Nutr Biotechnol, Taichung 413305, Taiwan.
C3 National Taiwan University; China Medical University Taiwan; China
   Medical University Hospital - Taiwan; Asia University Taiwan
RP Pan, MH (corresponding author), Natl Taiwan Univ, Inst Food Sci & Technol, Taipei 106017, Taiwan.; Pan, MH (corresponding author), China Med Univ, China Med Univ Hosp, Dept Med Res, Taichung 404327, Taiwan.; Pan, MH (corresponding author), Asia Univ, Dept Hlth & Nutr Biotechnol, Taichung 413305, Taiwan.
EM mhpan@ntu.edu.tw
RI Pan, Min-Hsiung/AAT-8865-2021; yen chun, koh/LFT-5555-2024
OI KOH, YEN CHUN/0000-0001-7683-873X; Pan, Min-Hsiung/0000-0002-5188-7030
FU National Science and Technology Council, Taiwan [110-2320-B-002-019-MY3,
   111-2320-B-002-032-MY3]
FX This work was supported by the National Science and Technology Council,
   Taiwan, under Grants [110-2320-B-002-019-MY3] and
   [111-2320-B-002-032-MY3].
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NR 131
TC 0
Z9 0
U1 2
U2 2
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 2470-1343
J9 ACS OMEGA
JI ACS Omega
PD JUL 9
PY 2024
VL 9
IS 29
BP 31298
EP 31312
DI 10.1021/acsomega.4c04120
EA JUL 2024
PG 15
WC Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry
GA A3L1X
UT WOS:001265806400001
PM 39072055
OA gold
DA 2025-06-11
ER

PT J
AU Akhter, A
   Alouffi, S
   Shahab, U
   Akasha, R
   Fazal-Ur-Rehman, M
   Ghoniem, ME
   Ahmad, N
   Kaur, K
   Pandey, RP
   Alshammari, A
   Akhter, F
   Ahmad, S
AF Akhter, Asma
   Alouffi, Sultan
   Shahab, Uzma
   Akasha, Rihab
   Fazal-Ur-Rehman, Mohd
   Ghoniem, Mohamed E.
   Ahmad, Naved
   Kaur, Kirtanjot
   Pandey, Ramendra Pati
   Alshammari, Ahmed
   Akhter, Firoz
   Ahmad, Saheem
TI Vitamin D supplementation modulates glycated hemoglobin (HBA1c) in
   diabetes mellitus
SO ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
LA English
DT Review
DE Diabetes; Receptor for advanced glycation end products; (RAGE);
   Hemoglobin A1c (HBA1c); Vitamin D
ID SERUM 25-HYDROXYVITAMIN D; IRON-DEFICIENCY ANEMIA; INSULIN-RESISTANCE;
   GLYCEMIC CONTROL; BIOLOGICAL VARIATION; GLUCOSE-METABOLISM;
   HYPOVITAMINOSIS-D; RECEPTOR GENE; RISK; ASSOCIATION
AB Diabetes is a metabolic illness that increases protein glycosylation in hyperglycemic conditions, which can have an impact on almost every organ system in the body. The role of vitamin D in the etiology of diabetes under RAGE (receptor for advanced glycation end products) stress has recently received some attention on a global scale. Vitamin D's other skeletal benefits have generated a great deal of research. Vitamin D's function in the development of type 1 and type 2 diabetes is supported by the discovery of 1,25 (OH)2D3 and 1-Alpha-Hydroylase expression in immune cells, pancreatic beta cells, and several other organs besides the bone system. A lower HBA1c level, metabolic syndrome, and diabetes mellitus all seems to be associated with vitamin D insufficiency. Most of the cross-sectional and prospective observational studies that were used to gather human evidence revealed an inverse relationship between vitamin D level and the prevalence or incidence of elevated HBA1c in type 2 diabetes. Several trials have reported on the impact of vitamin D supplementation for glycemia or incidence of type 2 diabetes, with varying degrees of success. The current paper examines the available data for a relationship between vitamin D supplementation and HBA1c level in diabetes and discusses the biological plausibility of such a relationship.
C1 [Akhter, Asma; Akhter, Firoz] SUNY Stony Brook, Dept Biomed Engn, Stony Brook, NY 11790 USA.
   [Alouffi, Sultan; Akasha, Rihab; Ahmad, Saheem] Univ Hail, Coll Appl Med Sci, Dept Med Lab Sci, Hail 2440, Saudi Arabia.
   [Shahab, Uzma] King George Med Univ, Dept Biochem, Lucknow, Uttar Pradesh, India.
   [Fazal-Ur-Rehman, Mohd] Aligarh Muslim Univ, Dept Zool, Aligarh, India.
   [Ghoniem, Mohamed E.] Univ Hail, Coll Med, Dept Internal Med, Hail 2440, Saudi Arabia.
   [Ahmad, Naved] Almaarefa Univ, Coll Appl Sci, Dept Comp Sci & Informat Syst, POB 71666, Riyadh 11597, Saudi Arabia.
   [Kaur, Kirtanjot] Chandigarh Univ, Univ Ctr Res & Dev, Mohali, Punjab, India.
   [Pandey, Ramendra Pati] UPES, Sch Hlth Sci & Technol SoHST, Dehra Dun 248007, Uttrakhand, India.
   [Alshammari, Ahmed] Univ Hail, Coll Med, Dept Internal Med, Hail, Saudi Arabia.
   Zagazig Univ, Fac Med, Dept Internal Med, Zagazig 44519, Egypt.
C3 State University of New York (SUNY) System; Stony Brook University;
   University Ha'il; King George's Medical University; Aligarh Muslim
   University; University Ha'il; Almaarefa University; Chandigarh
   University; University of Petroleum & Energy Studies (UPES); University
   Ha'il; Egyptian Knowledge Bank (EKB); Zagazig University
RP Akhter, F (corresponding author), SUNY Stony Brook, Dept Biomed Engn, Stony Brook, NY 11790 USA.; Ahmad, S (corresponding author), Univ Hail, Coll Appl Med Sci, Dept Med Lab Sci, Hail 2440, Saudi Arabia.
EM fnu.asma.1@stonybrook.edu; s.alouffi@uoh.edu.sa; uzmashahab@gmail.com;
   rihabakasha@gmail.com; mf.rehman5681@gmail.com; mo.ghonim@uoh.edu.sa;
   nahmad@um.edu.sa; kirtanjot@gmail.com; ramendra.pandey@gmail.com;
   ahmed.alshammari@uoh.edu.sa; firozakhter86@gmail.com;
   ahmadsaheem@gmail.com
RI Ahmad, Naved/G-6198-2018; Akhter, Firoz/AAD-2281-2022; Shahab,
   Uzma/AAR-4332-2021; ghoniem, mohamed/AGA-1167-2022; Pandey, Ramendra
   pati/AAE-6970-2021; Alouffi, Sultan/AAJ-5069-2020; Al-Shammari, Dr
   Ahmed/HTR-2311-2023; Ahmad, Saheem/R-7016-2017; Akasha,
   Rihab/AAR-5456-2021
OI Ghoniem, Mohamed/0000-0002-3957-4365; Pandey, Ramendra
   pati/0000-0002-5196-6468; Akhter, Firoz/0000-0002-8836-601X
FU Scientific Research Deanship at the University of Ha'il-Saudi Arabia; 
   [RG-23142]
FX This research has been funded by the Scientific Research Deanship at the
   University of Ha'il-Saudi Arabia through project number RG-23142.
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NR 156
TC 4
Z9 4
U1 1
U2 5
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0003-9861
EI 1096-0384
J9 ARCH BIOCHEM BIOPHYS
JI Arch. Biochem. Biophys.
PD MAR
PY 2024
VL 753
AR 109911
DI 10.1016/j.abb.2024.109911
EA JAN 2024
PG 9
WC Biochemistry & Molecular Biology; Biophysics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics
GA JR2C6
UT WOS:001174817600001
PM 38280562
DA 2025-06-11
ER

PT J
AU Xiao, LL
   Tang, R
   Wang, J
   Wan, D
   Yin, YL
   Xie, LW
AF Xiao, Lanling
   Tang, Rui
   Wang, Jie
   Wan, Dan
   Yin, Yulong
   Xie, Liwei
TI Gut microbiota bridges the iron homeostasis and host health
SO SCIENCE CHINA-LIFE SCIENCES
LA English
DT Review
DE gut microbiota; iron; metabolic syndrome; diseases
ID CHAIN FATTY-ACIDS; SYSTEMIC-LUPUS-ERYTHEMATOSUS; MITOCHONDRIAL
   METABOLISM; PROMOTES FERROPTOSIS; ULCERATIVE-COLITIS; HEME-SYNTHESIS;
   BILE-ACIDS; DISEASE; INFLAMMATION; PROTEIN
AB The gut microbiota acts as a symbiotic microecosystem that plays an indispensable role in the regulation of a number of metabolic processes in the host by secreting secondary metabolites and impacting the physiology and pathophysiology of numerous organs and tissues through the circulatory system. This relationship, referred to as the "gut-X axis", is associated with the development and progression of disorders, including obesity, fatty liver and Parkinson's disease. Given its importance, the gut flora is a vital research area for the understanding and development of the novel therapeutic approaches for multiple disorders. Iron is a common but necessary element required by both mammals and bacteria. As a result, iron metabolism is closely intertwined with the gut microbiota. The host's iron homeostasis affects the composition of the gut microbiota and the interaction between host and gut microbiota through various mechanisms such as nutrient homeostasis, intestinal peaceability, gut immunity, and oxidative stress. Therefore, understanding the relationship between gut microbes and host iron metabolism is not only of enormous significance to host health but also may offer preventative and therapeutic approaches for a number of disorders that impact both parties. In this review, we delve into the connection between the dysregulation of iron metabolism and dysbiosis of gut microbiota, and how it contributes to the onset and progression of metabolic and chronic diseases.
C1 [Xiao, Lanling; Wang, Jie; Xie, Liwei] Guangdong Acad Sci, State Key Lab Appl Microbiol Southern China, Guangdong Prov Key Lab Microbial Culture Collect &, Guangdong Open Lab Appl Microbiol,Inst Microbiol, Guangzhou 510070, Peoples R China.
   [Xiao, Lanling; Wan, Dan; Yin, Yulong] Chinese Acad Sci, Inst Subtrop Agr, Lab Anim Nutr Physiol & Metab Proc, Key Lab Agroecol Proc Subtrop Reg, Changsha 410125, Peoples R China.
   [Xiao, Lanling; Wan, Dan; Yin, Yulong] Univ Chinese Acad Sci, Beijing 101408, Peoples R China.
   [Tang, Rui] Jinan Univ, Dept Psychiat, Affiliated Hosp 1, Guangzhou 510000, Peoples R China.
   [Xie, Liwei] Southern Med Univ, Zhujiang Hosp, Dept Endocrinol & Metab, Guangzhou 510280, Peoples R China.
   [Xie, Liwei] Xinxiang Med Univ, Sch Publ Hlth, Xinxiang 453003, Peoples R China.
   [Xie, Liwei] Southern Med Univ, Shunde Hosp, Dept Stomatol, Peoples Hosp Shunde 1, Foshan 528308, Peoples R China.
   [Wang, Jie] Imperial Coll London, Dept Life Sci, London SW7 2AZ, England.
C3 Guangdong Academy of Sciences; Chinese Academy of Sciences; Institute of
   Subtropical Agriculture, CAS; Chinese Academy of Sciences; University of
   Chinese Academy of Sciences, CAS; Jinan University; Southern Medical
   University - China; Xinxiang Medical University; Southern Medical
   University - China; Imperial College London
RP Xie, LW (corresponding author), Guangdong Acad Sci, State Key Lab Appl Microbiol Southern China, Guangdong Prov Key Lab Microbial Culture Collect &, Guangdong Open Lab Appl Microbiol,Inst Microbiol, Guangzhou 510070, Peoples R China.; Wan, D; Yin, YL (corresponding author), Chinese Acad Sci, Inst Subtrop Agr, Lab Anim Nutr Physiol & Metab Proc, Key Lab Agroecol Proc Subtrop Reg, Changsha 410125, Peoples R China.; Wan, D; Yin, YL (corresponding author), Univ Chinese Acad Sci, Beijing 101408, Peoples R China.; Xie, LW (corresponding author), Southern Med Univ, Zhujiang Hosp, Dept Endocrinol & Metab, Guangzhou 510280, Peoples R China.; Xie, LW (corresponding author), Xinxiang Med Univ, Sch Publ Hlth, Xinxiang 453003, Peoples R China.; Xie, LW (corresponding author), Southern Med Univ, Shunde Hosp, Dept Stomatol, Peoples Hosp Shunde 1, Foshan 528308, Peoples R China.
EM w.dan@isa.ac.cn; yinyulong@isa.ac.cn; xielw@gdim.cn
FU Guangdong Basic and Applied Basic Research Foundation [2020B1515020046];
   "GDAS" Project of Science and Technology Development
   [2021GDASYL-20210102003]; National Natural Science Foundation of China
   [81900797, 82072436]; State Key Laboratory of Applied Microbiology
   Southern China [SKLAM002-2020]
FX This work was supported by Guangdong Basic and Applied Basic Research
   Foundation (2020B1515020046), "GDAS" Project of Science and Technology
   Development (2021GDASYL-20210102003), the National Natural Science
   Foundation of China (81900797, 82072436), and State Key Laboratory of
   Applied Microbiology Southern China (SKLAM002-2020).
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NR 238
TC 25
Z9 28
U1 15
U2 65
PU SCIENCE PRESS
PI BEIJING
PA 16 DONGHUANGCHENGGEN NORTH ST, BEIJING 100717, PEOPLES R CHINA
SN 1674-7305
EI 1869-1889
J9 SCI CHINA LIFE SCI
JI Sci. China-Life Sci.
PD SEP
PY 2023
VL 66
IS 9
SI SI
BP 1952
EP 1975
DI 10.1007/s11427-022-2302-5
EA JUL 2023
PG 24
WC Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics
GA R6GF1
UT WOS:001039257900001
PM 37515687
OA Bronze
DA 2025-06-11
ER

PT J
AU van den Brink, W
   Bloem, R
   Ananth, A
   Kanagasabapathi, T
   Amelink, A
   Bouwman, J
   Gelinck, G
   van Veen, S
   Boorsma, A
   Wopereis, S
AF van den Brink, Willem
   Bloem, Robbert
   Ananth, Adithya
   Kanagasabapathi, Thiru
   Amelink, Arjen
   Bouwman, Jildau
   Gelinck, Gerwin
   van Veen, Sjaak
   Boorsma, Andre
   Wopereis, Suzan
TI Digital Resilience Biomarkers for Personalized Health Maintenance and
   Disease Prevention
SO FRONTIERS IN DIGITAL HEALTH
LA English
DT Review
DE digital biomarker; prevention; lifestyle intervention; optical sensing;
   wearable sensors; resilience
ID HEART-RATE-VARIABILITY; BLOOD-PRESSURE VARIABILITY; GLUCOSE-TOLERANCE
   TEST; INSULIN SENSITIVITY; METABOLIC SYNDROME; GAIT VARIABILITY; STRESS;
   RISK; NUTRITION; MECHANISMS
AB Health maintenance and disease prevention strategies become increasingly prioritized with increasing health and economic burden of chronic, lifestyle-related diseases. A key element in these strategies is the empowerment of individuals to control their health. Self-measurement plays an essential role in achieving such empowerment. Digital measurements have the advantage of being measured non-invasively, passively, continuously, and in a real-world context. An important question is whether such measurement can sensitively measure subtle disbalances in the progression toward disease, as well as the subtle effects of, for example, nutritional improvement. The concept of resilience biomarkers, defined as the dynamic evaluation of the biological response to an external challenge, has been identified as a viable strategy to measure these subtle effects. In this review, we explore the potential of integrating this concept with digital physiological measurements to come to digital resilience biomarkers. Additionally, we discuss the potential of wearable, non-invasive, and continuous measurement of molecular biomarkers. These types of innovative measurements may, in the future, also serve as a digital resilience biomarker to provide even more insight into the personal biological dynamics of an individual. Altogether, digital resilience biomarkers are envisioned to allow for the measurement of subtle effects of health maintenance and disease prevention strategies in a real-world context and thereby give personalized feedback to improve health.
C1 [van den Brink, Willem; Bouwman, Jildau; Boorsma, Andre; Wopereis, Suzan] Netherlands Org Appl Sci Res TNO, Dept Microbiol & Syst Biol, Zeist, Netherlands.
   [Bloem, Robbert; van Veen, Sjaak] Netherlands Org Appl Sci Res TNO, Dept Environm Modeling Sensing & Anal, Utrecht, Netherlands.
   [Ananth, Adithya; Amelink, Arjen] Netherlands Org Appl Sci Res TNO, Dept Opt, Delft, Netherlands.
   [Kanagasabapathi, Thiru; Gelinck, Gerwin] Netherlands Org Appl Sci Res TNO, Holst Ctr, Eindhoven, Netherlands.
C3 Netherlands Organization Applied Science Research; Netherlands
   Organization Applied Science Research; Netherlands Organization Applied
   Science Research; Netherlands Organization Applied Science Research
RP van den Brink, W (corresponding author), Netherlands Org Appl Sci Res TNO, Dept Microbiol & Syst Biol, Zeist, Netherlands.
EM willem.vandenbrink@tno.nl
OI Bloem, Elin/0000-0001-5854-6733
FU TNO Roadmap Digital Health Technologies - Dutch government
FX The authors declare that the work was internally funded by TNO Roadmap
   Digital Health Technologies. TNO is a not-for-profit research
   organization. TNO research projects are funded by the Dutch government
   and commercial parties that did not influence this work.
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NR 110
TC 16
Z9 17
U1 3
U2 17
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 2673-253X
J9 FRONT DIGIT HEALTH
JI Front. Digit. Health
PD JAN 22
PY 2021
VL 2
AR 614670
DI 10.3389/fdgth.2020.614670
PG 13
WC Health Care Sciences & Services; Medical Informatics
WE Emerging Sources Citation Index (ESCI)
SC Health Care Sciences & Services; Medical Informatics
GA N0JF2
UT WOS:001033975500001
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Park, E
   Lee, CG
   Jeong, H
   Yeo, S
   Kim, JA
   Jeong, SY
AF Park, Eunkuk
   Lee, Chang Gun
   Jeong, Hyesoo
   Yeo, Subin
   Kim, Ji Ae
   Jeong, Seon-Yong
TI Antiadipogenic Effects of Mixtures of Cornus officinalis and
   Ribes fasciculatum Extracts on 3T3-L1 Preadipocytes and High-Fat
   Diet-Induced Mice
SO MOLECULES
LA English
DT Article
DE obesity; Cornus; officinalis; Ribes; fasciculatum; high-fat diet;
   natural product
ID ACTIVATED-RECEPTOR-GAMMA; PPAR-GAMMA; C/EBP-ALPHA; INSULIN-RESISTANCE;
   METABOLIC SYNDROME; HEPATIC STEATOSIS; ADIPOSE-TISSUE; OBESITY;
   ADIPOGENESIS; LIVER
AB Medicinal plants have been used worldwide as primary alternative healthcare supplements. Cornus officinalis (CO) and Ribes fasciculatum (RF) are traditional medicinal plants applied in East Asia to treat human diseases such as hepatitis, osteoporosis, oxidative stress and allergy. The aim of this study was to examine the anti-obesity effect of CO and RF on preadipocyte 3T3-L1 cells in vitro and high-fat diet (HFD)-induced obesity mice in vivo. Combination treatment of CO and RF in differentiated 3T3-L1 cells inhibited adipocyte differentiation through downregulation of adipogenesis-associated genes such as CCAAT/enhancer-binding protein alpha (Cebpa), fatty acid binding protein 4 (Fabp4), peroxisome proliferator-activated receptor gamma (Pparg) and sterol regulatory element binding protein (Srebp1). In vivo animal models showed that a mixture of CO and RF inhibited HFD-induced weight gain, resulting in decreased abdominal visceral fat tissues and fatty hepatocyte deposition. In addition, CO+RF treatment decreased HFD-induced adipogenesis-associated genes in abdominal white fat tissue. These results suggest that administration of a CO and RF mixture prevented adipocyte differentiation and lipid accumulation in preadipocyte cells and HFD-induced body weight in obesity mice. Therefore, combined therapy of CO and RF may be a protective therapeutic agent against obesity.
C1 [Park, Eunkuk; Lee, Chang Gun; Jeong, Seon-Yong] Ajou Univ, Dept Med Genet, Sch Med, Suwon 16499, South Korea.
   [Park, Eunkuk; Lee, Chang Gun; Jeong, Seon-Yong] Ajou Univ, Dept Biomed Sci, Grad Sch Med, Suwon 16499, South Korea.
   [Jeong, Hyesoo; Yeo, Subin; Kim, Ji Ae] Nine B Co, Daejeon 34121, South Korea.
C3 Ajou University; Ajou University
RP Jeong, SY (corresponding author), Ajou Univ, Dept Med Genet, Sch Med, Suwon 16499, South Korea.; Jeong, SY (corresponding author), Ajou Univ, Dept Biomed Sci, Grad Sch Med, Suwon 16499, South Korea.
EM jude0815@hotmail.com; dangsunsang@naver.com; jhyesoo921@gmail.com;
   snsnans@naver.com; ji.ae.kim@daum.net; jeongsy@ajou.ac.kr
RI Park, Eunkuk/MXL-4258-2025
OI park, eunkuk/0000-0002-1928-5531; Jeong, Seon-Yong/0000-0002-0625-3530;
   Kim, Ji Ae/0000-0001-7016-7357; Lee, Chang-Gun/0000-0002-2031-0802
FU High Value-Added Food Technology Development Program, Ministry of
   Agriculture, Food, and Rural Affairs [117041-03-1-SB010]; INNOPOLIS
   Foundation, Ministry of Science and ICT by the Korean government
   [2019-DD-RD-0088]; Ministry of Science and ICT [2019A000022]
FX This study was supported by a grant from High Value-Added Food
   Technology Development Program, Ministry of Agriculture, Food, and Rural
   Affairs (117041-03-1-SB010), Ministry of Science and ICT (2019A000022)
   and a grant from the INNOPOLIS Foundation, Ministry of Science and ICT
   by the Korean government (2019-DD-RD-0088).
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NR 53
TC 17
Z9 18
U1 0
U2 9
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1420-3049
J9 MOLECULES
JI Molecules
PD MAY
PY 2020
VL 25
IS 10
AR 2350
DI 10.3390/molecules25102350
PG 11
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA LW6ZT
UT WOS:000539293400083
PM 32443487
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Yang, M
   Ni, CL
   Chang, BC
   Jiang, ZH
   Zhu, YJ
   Tang, YZ
   Li, Z
   Li, CG
   Li, B
AF Yang, Min
   Ni, Changlin
   Chang, Baocheng
   Jiang, Zhenhuan
   Zhu, Yanjuan
   Tang, Yunzhao
   Li, Zhu
   Li, Chenguang
   Li, Bin
TI Association between serum total bilirubin levels and the risk of type 2
   diabetes mellitus
SO DIABETES RESEARCH AND CLINICAL PRACTICE
LA English
DT Article
DE Total bilirubin; Type 2 diabetes mellitus; Impaired glucose regulation;
   Risk factor
ID INCREASES INSULIN SENSITIVITY; METABOLIC SYNDROME; HEME OXYGENASE;
   PREVALENCE; ALBUMINURIA; NEUROPATHY; STRESS; MICE; MEN
AB Aim: To confirm whether serum bilirubin is an independent risk factor of type 2 diabetes mellitus (T2DM) onset in patients with impaired fasting glycemia (IFG) and impaired glucose tolerance (IGT).
   Methods: This was a prospective cohort study carried out at the Diabetic Identification Center of Tianjin Metabolic Diseases Hospital. Serum total bilirubin (TBIL) was measured at baseline and the patients were grouped according to baseline bilirubin quartiles. The outcome was the confirmation of T2DM by oral glucose tolerance test (OGTT) during the 3-year follow-up. Logistic regression was used to determine the risk factors for T2DM development and whether bilirubin levels are independently associated with T2DM development.
   Results: Finally, 523 patients were analyzed. After 3 years, 310 participants were diagnosed with diabetes based on OGTT. Baseline quartiles of total bilirubin were inversely associated with diabetes risk, even after multivariable adjustment. The adjusted ORs for diabetes were 1.0 (reference), 0.83 (95% CI 0.74-0.96), 0.78 (95% CI 0.68-0.90), 0.74 (95% CI 0.64-0.87) for the 1st, 2nd, 3rd, and 4th quartiles of baseline serum total bilirubin, respectively (P < 0.001).
   Conclusion: In patients with IFG or IGT, low levels of serum total bilirubin were associated with a significantly increased risk of T2DM. (C) 2019 The Authors. Published by Elsevier B.V.
C1 [Yang, Min; Ni, Changlin; Chang, Baocheng; Jiang, Zhenhuan; Zhu, Yanjuan; Tang, Yunzhao; Li, Zhu; Li, Chenguang; Li, Bin] Tianjin Med Univ, Metab Dis Hosp, Tianjin Key Lab Metab Dis, NHC Key Lab Hormones & Dev, Tianjin 300070, Peoples R China.
   [Yang, Min; Ni, Changlin; Chang, Baocheng; Jiang, Zhenhuan; Zhu, Yanjuan; Tang, Yunzhao; Li, Zhu; Li, Chenguang; Li, Bin] Tianjin Inst Endocrinol, Tianjin 300070, Peoples R China.
C3 Tianjin Medical University
RP Yang, M (corresponding author), Tianjin Med Univ, Metab Dis Hosp, Tianjin Key Lab Metab Dis, NHC Key Lab Hormones & Dev, Tianjin 300070, Peoples R China.
EM mminyang2005@163.com
RI JIANG, ZHENHUAN/KCD-7096-2024
FU Natural Science Foundation of China [81600628]; Natural Science
   Foundation of Tianjin [16JCYBJC 25700]; Science AMP; Technology
   Development Fund of Tianjin Education Commission for Higher Education
   [2018KJ017]
FX We are grateful to the investigators who conducted the study as well as
   the subjects who participated in our present study. This study was
   supported by the Natural Science Foundation of China (grant no.
   81600628), the Natural Science Foundation of Tianjin (grant no. 16JCYBJC
   25700) and the Science & Technology Development Fund of Tianjin
   Education Commission for Higher Education (grant no. 2018KJ017).
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NR 40
TC 31
Z9 33
U1 0
U2 21
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0168-8227
EI 1872-8227
J9 DIABETES RES CLIN PR
JI Diabetes Res. Clin. Pract.
PD JUN
PY 2019
VL 152
BP 23
EP 28
DI 10.1016/j.diabres.2019.04.033
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA IC6YA
UT WOS:000471117400004
PM 31078667
OA hybrid
DA 2025-06-11
ER

PT J
AU Itabe, H
   Kato, R
   Sawada, N
   Obama, T
   Yamamoto, M
AF Itabe, Hiroyuki
   Kato, Rina
   Sawada, Naoko
   Obama, Takashi
   Yamamoto, Matsuo
TI The Significance of Oxidized Low-Density Lipoprotein in Body Fluids as a
   Marker Related to Diseased Conditions
SO CURRENT MEDICINAL CHEMISTRY
LA English
DT Review
DE lipoproteins; oxLDL; oxLDL/LDL ratio; oxidized phosphatidylcholine; AMI;
   periodontitis; GCF; transcytosis
ID ACUTE CORONARY SYNDROMES; OXIDATION-SPECIFIC BIOMARKERS;
   MALONDIALDEHYDE-MODIFIED LDL; GINGIVAL CREVICULAR FLUID;
   APOLIPOPROTEIN-B; IN-VIVO; ATHEROSCLEROTIC LESIONS; PLASMA-LEVELS;
   MONOCLONAL-ANTIBODY; METABOLIC SYNDROME
AB Oxidatively modified low-density lipoprotein (oxLDL) is known to be involved in various diseases, including cardiovascular diseases. The presence of oxLDL in the human circulatory system and in atherosclerotic lesions has been demonstrated using monoclonal antibodies. Studies have shown the significance of circulating oxLDL in various systemic diseases, including acute myocardial infarction and diabetic mellitus. Several different enzyme-linked immunosorbent assay (ELISA) procedures to measure oxLDL were utilized. Evidence has been accumulating that reveals changes in oxLDL levels under certain pathological conditions. Since oxLDL concentration tends to correlate with low-density lipoprotein (LDL)-cholesterol, the ratio of ox-LDL and LDL rather than oxLDL concentration alone has also been focused. In addition to circulating plasma, LDL and oxLDL are found in gingival crevicular fluid (GCF), where the ratio of oxLDL to LDL in GCF is much higher than in plasma. LDL and oxLDL levels in GCF show an increase in diabetic patients and periodontal patients, suggesting that GCF might be useful in examining systemic conditions. GCF oxLDL increased when the teeth were affected by periodontitis. It is likely that oxLDL levels in plasma and GCF could reflect oxidative stress and transfer efficacy in the circulatory system.
C1 [Itabe, Hiroyuki; Kato, Rina; Sawada, Naoko; Obama, Takashi] Showa Univ, Dept Mol Biol, Div Biol Chem, Sch Pharm, Tokyo 1428555, Japan.
   [Yamamoto, Matsuo] Showa Univ, Dept Periodontol, Sch Dent, Tokyo, Japan.
C3 Showa University; Showa University
RP Itabe, H (corresponding author), Showa Univ, Dept Mol Biol, Div Biol Chem, Sch Pharm, Tokyo 1428555, Japan.
EM h-itabe@pharm.showa-u.ac.jp
RI 板部板部, 洋之/ABC-7746-2020
FU JSPS KAKENHI [15K07944, 24590094]; MEXT; Grants-in-Aid for Scientific
   Research [15K07944, 16K08245, 24590094] Funding Source: KAKEN
FX This work was supported in part by grants from JSPS KAKENHI (Grant
   number 15K07944, 24590094) to HI and a MEXT-supported program for the
   Private Universities Research Branding Project (2016-2020).
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NR 147
TC 20
Z9 20
U1 1
U2 15
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 0929-8673
EI 1875-533X
J9 CURR MED CHEM
JI Curr. Med. Chem.
PY 2019
VL 26
IS 9
BP 1576
EP 1593
DI 10.2174/0929867325666180307114855
PG 18
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Pharmacology &
   Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
GA HY9JI
UT WOS:000468456000005
PM 29521196
DA 2025-06-11
ER

PT J
AU Kim, HB
   Lee, HS
   Lee, YJ
AF Kim, H. -B.
   Lee, H. -S.
   Lee, Y. -J.
TI Association of serum ferritin levels with non-alcoholic fatty liver
   disease in postmenopausal women
SO CLIMACTERIC
LA English
DT Article
DE Ferritin; non-alcoholic fatty liver disease; insulin resistance;
   inflammation; menopause
ID METABOLIC SYNDROME; INSULIN-RESISTANCE; OXIDATIVE STRESS; HEPATIC
   STEATOSIS; OBESE-PATIENTS; CELL FUNCTION; FOLLOW-UP; RISK;
   STEATOHEPATITIS; PATHOGENESIS
AB Objective: This study aimed to investigate the association between serum ferritin levels and the presence of non-alcoholic fatty liver disease (NAFLD) in postmenopausal women.Methods: Two hundred and forty-one postmenopausal women who participated in a heath examination program were enrolled in the present study. Serum ferritin tertiles were categorized as follows: T1, 46.4ng/ml; T2, 46.5-76.1ng/ml; and T3, 76.2ng/ml. The odds ratios (ORs) and 95% confidence intervals (CIs) for NAFLD were calculated after adjusting for confounding variables across serum ferritin tertiles using multiple logistic regression analysis.Results: The overall prevalence of NAFLD was 41.4% and was significantly increased in accordance with the serum ferritin tertiles as follows: 30.0% for T1, 40.7% for T2, and 54.3% for T3, respectively. As compared with the lowest tertile, the OR (95% CI) for NAFLD in the highest tertile was 2.69 (1.16-5.28) after adjusting for age, body mass index, regular exercise, mean arterial pressure, fasting plasma glucose, triglyceride, high-density lipoprotein cholesterol, alanine aminotransferase, and leukocyte count.Conclusion: The serum ferritin level was positively and independently associated with NAFLD in postmenopausal women and could be a useful additional measure in assessing the risk of NAFLD in postmenopausal women.
C1 [Kim, H. -B.] Myongji Hosp, Dept Family Med, Goyang, South Korea.
   [Lee, H. -S.] Yonsei Univ, Coll Med, Biostat Collaborat Unit, Seoul, South Korea.
   [Lee, Y. -J.] Yonsei Univ, Coll Med, Dept Family Med, Seoul, South Korea.
C3 Myongji Hospital; Yonsei University; Yonsei University Health System;
   Yonsei University; Yonsei University Health System
RP Lee, YJ (corresponding author), Yonsei Univ, Gangnam Severance Hosp, Coll Med, Dept Family Med, 211 Eonju Ro, Seoul, South Korea.
EM ukyjhome@yuhs.ac
RI Lee, Yong Jae/GLR-4153-2022; Lee, Hye Sun/J-2154-2015
OI Lee, Hye Sun/0000-0001-6328-6948; Lee, Yong-Jae/0000-0002-6697-476X
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NR 35
TC 9
Z9 9
U1 0
U2 4
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1369-7137
EI 1473-0804
J9 CLIMACTERIC
JI Climacteric
PY 2018
VL 21
IS 5
BP 509
EP 514
DI 10.1080/13697137.2018.1493451
PG 6
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA GV4AI
UT WOS:000446039300016
PM 30106314
DA 2025-06-11
ER

PT J
AU Yang, Y
   Hu, S
   Liu, J
   Cui, Y
   Fan, Y
   Lv, TJ
   Liu, LB
   Li, J
   He, Q
   Han, WK
   Yu, W
   Sun, Y
   Jin, J
AF Yang, Yang
   Hu, Shuai
   Liu, Jie
   Cui, Yun
   Fan, Yu
   Lv, Tianjing
   Liu, Libo
   Li, Jun
   He, Qun
   Han, Wenke
   Yu, Wei
   Sun, Yin
   Jin, Jie
TI CD8+T cells promote proliferation of benign prostatic hyperplasia
   epithelial cells under low androgen level via modulation of
   CCL5/STAT5/CCND1 signaling pathway
SO SCIENTIFIC REPORTS
LA English
DT Article
ID URINARY-TRACT SYMPTOMS; METABOLIC SYNDROME; CLINICAL PROGRESSION;
   COMBINATION THERAPY; RECEPTOR EXPRESSION; OXIDATIVE STRESS;
   GROWTH-FACTOR; CANCER CELLS; INFLAMMATION; FINASTERIDE
AB Previous studies by our group have shown that low intra-prostatic dihydrotestosterone (DHT) induced BPH epithelial cells (BECs) to recruit CD8+ T cells. However, the influence of the recruited CD8+ T cells on BECs under a low androgen level is still unknown. Here, we found CD8+ T cells have the capacity to promote proliferation of BECs in low androgen condition. Mechanism dissection revealed that interaction between CD8+ T cells and BECs through secretion of CCL5 might promote the phosphorylation of STAT5 and a higher expression of CCND1 in BECs. Suppressed CCL5/STAT5 signals via CCL5 neutralizing antibody or STAT5 inhibitor Pimozide led to reverse CD8+ T cell-enhanced BECs proliferation. IHC analysis from Finasteride treated patients showed PCNA expression in BECs was highly correlated to the level of CD8+ T cell infiltration and the expression of CCL5. Consequently, our data indicated infiltrating CD8+ T cells could promote the proliferation of BECs in low androgen condition via modulation of CCL5/STAT5/CCND1 signaling. The increased secretion of CCL5 from the CD8+ T cells/BECs interaction might help BECs survive in a low DHT environment. Targeting these signals may provide a new potential therapeutic approach to better treat BPH patients who failed the therapy of 5 alpha-reductase inhibitors.
C1 [Yang, Yang; Hu, Shuai; Cui, Yun; Fan, Yu; Lv, Tianjing; Liu, Libo; Li, Jun; He, Qun; Han, Wenke; Yu, Wei; Jin, Jie] Peking Univ, Hosp 1, Dept Urol, Beijing 100034, Peoples R China.
   [Yang, Yang; Hu, Shuai; Cui, Yun; Fan, Yu; Lv, Tianjing; Liu, Libo; Li, Jun; He, Qun; Han, Wenke; Yu, Wei; Jin, Jie] Peking Univ, Inst Urol, Beijing 100034, Peoples R China.
   [Yang, Yang; Hu, Shuai; Cui, Yun; Fan, Yu; Lv, Tianjing; Liu, Libo; Li, Jun; He, Qun; Han, Wenke; Jin, Jie] Natl Res Ctr Genitourinary Oncol, Beijing 100034, Peoples R China.
   [Yang, Yang; Hu, Shuai; Cui, Yun; Fan, Yu; Lv, Tianjing; Liu, Libo; Li, Jun; He, Qun; Han, Wenke; Yu, Wei; Jin, Jie] Urogenital Dis Male Mol Diag & Treatment Ctr, Beijing 100034, Peoples R China.
   [Liu, Jie] Linyi Peoples Hosp, Dept Urol, Linyi 276003, Shandong, Peoples R China.
   [Sun, Yin] Univ Rochester, Med Ctr, Dept Radiat Oncol, Rochester, NY 14642 USA.
C3 Peking University; Peking University; University of Rochester
RP Jin, J (corresponding author), Peking Univ, Hosp 1, Dept Urol, Beijing 100034, Peoples R China.; Jin, J (corresponding author), Peking Univ, Inst Urol, Beijing 100034, Peoples R China.; Jin, J (corresponding author), Natl Res Ctr Genitourinary Oncol, Beijing 100034, Peoples R China.; Jin, J (corresponding author), Urogenital Dis Male Mol Diag & Treatment Ctr, Beijing 100034, Peoples R China.
EM jinjie@vip.163.com
RI Li, Yingrui/K-1064-2015; Jin, Jie/GQH-8572-2022; Yu, Wei/NFT-0095-2025;
   Hu, Shuai/JVP-2058-2024
OI Yang, Yang/0000-0001-5877-6467
FU National Natural Science Foundation of China [81370858, 81570683];
   Natural Science Foundation of Beijing Municipality [7142161]
FX This work was supported by grants from the National Natural Science
   Foundation of China (No. 81370858 and 81570683), and the Natural Science
   Foundation of Beijing Municipality (No. 7142161). The authors also thank
   the Department of Urologic Pathology, Peking University First Hospital,
   for patient samples and pathological diagnosis.
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NR 66
TC 15
Z9 16
U1 1
U2 21
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD FEB 20
PY 2017
VL 7
AR 42893
DI 10.1038/srep42893
PG 12
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA EL3QQ
UT WOS:000394534300001
PM 28216616
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Li, XL
   Sui, JQ
   Lu, LL
   Zhang, NN
   Xu, X
   Dong, QY
   Xin, YN
   Xuan, SY
AF Li, Xiao-Lin
   Sui, Jian-Qing
   Lu, Lin-Lin
   Zhang, Nan-Nan
   Xu, Xin
   Dong, Quan-Yong
   Xin, Yong-Ning
   Xuan, Shi-Ying
TI Gene polymorphisms associated with non-alcoholic fatty liver disease and
   coronary artery disease: a concise review
SO LIPIDS IN HEALTH AND DISEASE
LA English
DT Review
DE Non-alcoholic fatty liver disease; Coronary artery disease; Gene
   pathogenesis; Genetic polymorphisms
ID NECROSIS-FACTOR-ALPHA; LEPTIN-RECEPTOR GENE; PPAR-GAMMA GENE;
   ELEMENT-BINDING PROTEIN-2; SERUM-LIPID LEVELS; CARDIOVASCULAR-DISEASE;
   METABOLIC SYNDROME; ADIPONECTIN GENE; HEART-DISEASE; TNF-ALPHA
AB Non-alcoholic fatty liver disease (NAFLD) is a common chronic liver disease which represents a wide spectrum of hepatic damage. Several studies have reported that NAFLD is a strong independent risk factor for coronary artery disease (CAD). And patients with NAFLD are at higher risk and suggested undergoperiodic cardiovascular risk assessment. Cardiovascular disease (CVD) is responsible for the main cause of death in patients with NAFLD, and is mostly influenced by genetic factors. Both NAFLD and CAD are heterogeneous disease. Common pathways involved in the pathogenesis of NAFLD and CAD includes insulin resistance (IR), atherogenic dyslipidemia, subclinical inflammation, oxidative stress, etc. Genomic characteristics of these two diseases have been widely studied, further research about the association of these two diseases draws attention. The gene polymorphisms of adiponectin-encoding gene (ADIPOQ), leptin receptor (LEPR), apolipoprotein C3 (APOC3), peroxisome proliferator-activated receptors (PPAR), sterol regulatory elementbinding proteins (SREBP), transmembrane 6 superfamily member 2 (TM6SF2), microsomal triglyceride transfer protein (MTTP), tumor necrosis factors-alpha (TNF-alpha) and manganese superoxide dismutase (MnSOD) have been reported to be related to NAFLD and CAD. In this review, we aimed to provide an overview of recent insights into the genetic basis of NAFLD and CAD.
C1 [Li, Xiao-Lin; Zhang, Nan-Nan; Xu, Xin; Dong, Quan-Yong; Xin, Yong-Ning; Xuan, Shi-Ying] Dalian Med Univ, Qingdao Municipal Hosp, Dept Gastroenterol, Qingdao 266011, Peoples R China.
   [Sui, Jian-Qing; Xin, Yong-Ning; Xuan, Shi-Ying] Qingdao Municipal Hosp, Dept Gastroenterol, Qingdao 266011, Peoples R China.
   [Lu, Lin-Lin; Xin, Yong-Ning; Xuan, Shi-Ying] Digest Dis Key Lab Qingdao, Qingdao 266071, Peoples R China.
   [Lu, Lin-Lin] Qingdao Municipal Hosp, Cent Labs, Qingdao 266071, Peoples R China.
C3 Dalian Medical University; Qingdao Municipal Hospital; Qingdao Municipal
   Hospital; Qingdao Municipal Hospital
RP Xin, YN; Xuan, SY (corresponding author), Dalian Med Univ, Qingdao Municipal Hosp, Dept Gastroenterol, Qingdao 266011, Peoples R China.; Xin, YN; Xuan, SY (corresponding author), Qingdao Municipal Hosp, Dept Gastroenterol, Qingdao 266011, Peoples R China.; Xin, YN; Xuan, SY (corresponding author), Digest Dis Key Lab Qingdao, Qingdao 266071, Peoples R China.
EM xinyongning@163.com; xuansydxy@163.com
RI Li, Xiaolin/O-5795-2015; Zhang, Nan/GXH-0361-2022
FU National Natural Science Foundation of China [81170337/H0304]; Qingdao
   livelihood, science and technology project, China [14-2-3-17-nsh];
   Qingdao key health discipline development fund
FX This work was supported in part by National Natural Science Foundation
   of China (No. 81170337/H0304), Qingdao livelihood, science and
   technology project, China (grant No. 14-2-3-17-nsh) and Qingdao key
   health discipline development fund.
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NR 99
TC 35
Z9 38
U1 1
U2 32
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1476-511X
J9 LIPIDS HEALTH DIS
JI Lipids Health Dis.
PD MAR 10
PY 2016
VL 15
AR 53
DI 10.1186/s12944-016-0221-8
PG 8
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA DG0TX
UT WOS:000371779700001
PM 26965314
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Scazzocchio, B
   Varì, R
   Filesi, C
   Del Gaudio, I
   D'Archivio, M
   Santangelo, C
   Iacovelli, A
   Galvano, F
   Pluchinotta, FR
   Giovannini, C
   Masella, R
AF Scazzocchio, Beatrice
   Vari, Rosaria
   Filesi, Carmelina
   Del Gaudio, Ilaria
   D'Archivio, Massimo
   Santangelo, Carmela
   Iacovelli, Annunziata
   Galvano, Fabio
   Pluchinotta, Francesca Romana
   Giovannini, Claudio
   Masella, Roberta
TI Protocatechuic acid activates key components of insulin signaling
   pathway mimicking insulin activity
SO MOLECULAR NUTRITION & FOOD RESEARCH
LA English
DT Article
DE Adipocytes; Diet; Functional food; Insulin resistance; Insulin signaling
ID TYPE-2 DIABETIC-PATIENTS; LOW-DENSITY-LIPOPROTEIN; DIETARY POLYPHENOLS;
   ANTHOCYANIN INTAKE; BROCCOLI SPROUTS; RESISTANCE; RISK; STRESS; LDL;
   CYANIDIN-3-O-BETA-GLUCOSIDE
AB ScopeInsulin resistance represents an independent risk factor for metabolic and cardiovascular diseases. Researchers have been interested in identifying active harmless compounds, as many insulin-sensitizing drugs have shown unwanted side-effects. It has been demonstrated that anthocyanins and one of their representative metabolites, protocatechuic acid (PCA), ameliorate hyperglycemia, and insulin sensitivity. This study investigated the mechanism of action of PCA responsible for the glucose uptake upregulation.
   Methods and resultsIn human visceral adipocytes, PCA stimulated insulin receptor substrate-1 (IRS-1) tyrosine phosphorylation (+40% with respect to untreated cells) and the downstream events, i.e. phosphoinositide 3-kinase binding to IRS-1 and Akt phosphorylation (+100%, +180%, respectively, with respect to untreated cells). The insulin-like activity of PCA seemed to be mediated by insulin receptor since by inhibiting its autophosphorylation, the PCA effects were completely abolished. Furthermore, PCA was able to activate adenosine monophosphate-activated protein kinase, a serine/threonine kinase whose activation elicits insulin-sensitizing effects.
   ConclusionThis study showed that PCA stimulates the insulin signaling pathway in human adipocytes increasing GLUT4 translocation and glucose uptake. Decreasing insulin resistance is a most desirable aim to be reached for an effective therapeutic/preventive action against metabolic syndrome and type 2 diabetes. Identifying specific food/food components able to improve glucose metabolism can offer an attractive, novel, and economical strategy.
C1 [Scazzocchio, Beatrice; Vari, Rosaria; Filesi, Carmelina; Del Gaudio, Ilaria; D'Archivio, Massimo; Santangelo, Carmela; Giovannini, Claudio; Masella, Roberta] Italian Natl Inst Hlth, Dept Vet Publ Hlth & Food Safety, Rome, Italy.
   [Iacovelli, Annunziata] Fabia Mater Hosp, Rome, Italy.
   [Galvano, Fabio] Univ Catania, Dept Biol Chem Med Chem & Mol Biol, Catania, Italy.
   [Pluchinotta, Francesca Romana] S Donato Hosp, IRCCS, Milan, Italy.
C3 Istituto Superiore di Sanita (ISS); University of Catania; IRCCS
   Policlinico San Donato
RP Masella, R (corresponding author), Italian Natl Inst Hlth, Dept Vet Publ Hlth & Food Safety, Rome, Italy.
EM roberta.masella@iss.it
RI Giovannini, Claudio/A-9168-2013; scazzocchio, beatrice/B-4110-2015;
   Galvano, Fabio/JSL-7451-2023; Masella, Roberta/B-4109-2015; VARI',
   ROSARIA/B-4111-2015; D'Archivio, massimo/Z-4633-2019; Galvano,
   Fabio/F-8122-2010; SANTANGELO, CARMELA/D-5726-2011; Pluchinotta,
   Francesca Romana/J-7680-2016
OI Galvano, Fabio/0000-0003-0644-0755; SANTANGELO,
   CARMELA/0000-0002-4309-1745; Rosaria, Vari/0000-0003-0488-6702; Del
   Gaudio, Ilaria/0000-0001-6794-8291; Giovannini,
   Claudio/0000-0002-4228-1264; Masella, Roberta/0000-0002-3173-1573;
   Pluchinotta, Francesca Romana/0000-0001-7185-7157; Scazzocchio,
   Beatrice/0000-0002-5123-3897; D'Archivio, Massimo/0000-0001-8104-3421
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NR 61
TC 67
Z9 67
U1 0
U2 22
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1613-4125
EI 1613-4133
J9 MOL NUTR FOOD RES
JI Mol. Nutr. Food Res.
PD AUG
PY 2015
VL 59
IS 8
BP 1472
EP 1481
DI 10.1002/mnfr.201400816
PG 10
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA CO3KS
UT WOS:000359056700005
PM 25944785
DA 2025-06-11
ER

PT J
AU Jayanthy, G
   Subramanian, S
AF Jayanthy, G.
   Subramanian, S.
TI RA abrogates hepatic gluconeogenesis and insulin resistance by enhancing
   IRS-1 and AMPK signalling in experimental type 2 diabetes
SO RSC ADVANCES
LA English
DT Article
ID ACTIVATED PROTEIN-KINASE; FATTY-ACID SYNTHESIS; ROSMARINIC ACID; HIGH
   GLUCOSE; DIETARY POLYPHENOLS; METABOLIC SYNDROME; OXIDATIVE STRESS;
   SKELETAL-MUSCLE; LIVER; CELL
AB Hyperglycemia and insulin resistance are the primary features of type 2 diabetes (T2DM). Rosmarinic acid (RA), a dietary polyphenol that is found in culinary herbs like rosemary, mint, and basil, is reported to have a beneficial effect against diabetes. However, the mechanism of its action remains obscure. Oral administration of RA (100 mg kg(-1) b.w.) for a period of 30 days restored the levels of blood glucose and regulated the levels of circulating adipokines in the diabetic rats, portraying its insulin sensitising potency. The efficacy of RA in attenuating diabetic pathology is evident from the normal hepatic parenchymal structures in the livers of diabetic rats, which was demonstrated by histological and ultrastructural observations. Treatment with RA also decreased the expression of key gluconeogenic and lipogenic enzymes in the liver of diabetic rats and in insulin resistant HepG2 cells, which was found to be mediated via an AMPK cascade. RA treatment stimulates glucose uptake by enhancing GLUT-2 translocation and by inhibiting the serine phosphorylation of IRS-1 in the liver and insulin resistant HepG2 cells. These findings suggest that RA improves insulin sensitising effects in diabetic livers and in insulin resistant HepG2 cells, thereby preventing potential hepatic dysfunction by attenuating gluconeogenesis, blockading insulin signalling, and modulating glucose uptake via the AMPK pathway.
C1 [Jayanthy, G.; Subramanian, S.] Univ Madras, Dept Biochem, Madras 600025, Tamil Nadu, India.
C3 University of Madras
RP Subramanian, S (corresponding author), Univ Madras, Dept Biochem, Guindy Campus, Madras 600025, Tamil Nadu, India.
EM subbus2020@yahoo.co.in
FU University Grants Commission (UGC), New Delhi, India
FX The research fellowship (UGC-BSR) of the University Grants Commission
   (UGC), New Delhi, India, to Mrs G. Jayanthy is gratefully acknowledged.
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NR 73
TC 21
Z9 22
U1 0
U2 35
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
EI 2046-2069
J9 RSC ADV
JI RSC Adv.
PY 2015
VL 5
IS 55
BP 44053
EP 44067
DI 10.1039/c5ra04605j
PG 15
WC Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry
GA CI7SM
UT WOS:000354964900018
DA 2025-06-11
ER

PT J
AU Johnson, M
   Nriagu, J
   Hammad, A
   Savoie, K
   Jamil, H
AF Johnson, Markey
   Nriagu, Jerome
   Hammad, Adnan
   Savoie, Kathryn
   Jamil, Hikmet
TI Asthma, Environmental Risk Factors, and Hypertension Among Arab
   Americans in Metro Detroit
SO JOURNAL OF IMMIGRANT AND MINORITY HEALTH
LA English
DT Article
DE Asthma; Hypertension; Arab; Indoor air pollution; Environmental risk
   factors
ID CARDIOVASCULAR-DISEASE RISK; ETHNIC-DIFFERENCES; METABOLIC SYNDROME;
   PUBLIC-HEALTH; PARTICIPATORY RESEARCH; OBESITY-HYPERTENSION;
   INSULIN-RESISTANCE; GLOBAL BURDEN; STRESS; US
AB Asthma and obesity-related health problems disproportionately impact low-income ethnic minority communities residing in urban areas. Environmental risk factors, particularly those related to housing and indoor air, may impact the development or exacerbation of asthma. There is increasing evidence to suggest a link between obesity-related health problems and asthma. Previous studies have also reported that immigrant status may influence myriad risk factors and health outcomes among immigrant populations. The Arab American Environmental Health Project (AAEHP) was the first study to explore environmental health problems among Arab Americans. This paper examined whether hypertensive status modified the relationship between environmental risk factors and asthma among Arab Americans in metro Detroit. An environmental risk index (ERI) was used to quantify household environmental risk factors associated with asthma. Physician diagnosed hypertension was self-reported, and asthma status was determined using responses to a validated symptoms checklist and self-reported diagnosis by a physician. Hypertension significantly modified the relationship between ERI and asthma in this study population. The positive association between household environmental risk factors and asthma was stronger among participants diagnosed with hypertension. Effect modification of the relationship between environmental risk factors and asthma could have serious implications among high-risk communities. However, further research is needed to elucidate the relationships between hypertension, environmental risk factors, and asthma.
C1 [Johnson, Markey] US EPA, Epidemiol & Biomarkers Branch, Human Studies Div, Res Triangle Pk, NC 27711 USA.
   [Nriagu, Jerome] Univ Michigan, Sch Publ Hlth, Dept Environm Hlth Sci, Ann Arbor, MI 48109 USA.
   [Hammad, Adnan; Savoie, Kathryn] ACCESS Community Hlth & Res Ctr, Dearborn, MI USA.
   [Jamil, Hikmet] Wayne State Univ, Dept Family Med, Detroit, MI USA.
C3 United States Environmental Protection Agency; University of Michigan
   System; University of Michigan; Wayne State University
RP Johnson, M (corresponding author), US EPA, Epidemiol & Biomarkers Branch, Human Studies Div, MD 58A, Res Triangle Pk, NC 27711 USA.
EM johnson.marym@epa.gov
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NR 99
TC 23
Z9 27
U1 1
U2 12
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1557-1912
EI 1557-1920
J9 J IMMIGR MINOR HEALT
JI J. Immigr. Minor. Health
PD OCT
PY 2010
VL 12
IS 5
BP 640
EP 651
DI 10.1007/s10903-008-9205-8
PG 12
WC Public, Environmental & Occupational Health
WE Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA 645ZZ
UT WOS:000281506000004
PM 18998210
DA 2025-06-11
ER

PT J
AU Son, NH
   Yu, SQ
   Tuinei, J
   Arai, K
   Hamai, H
   Homma, S
   Shulman, GI
   Abel, ED
   Goldberg, IJ
AF Son, Ni-Huiping
   Yu, Shuiqing
   Tuinei, Joseph
   Arai, Kotaro
   Hamai, Hiroko
   Homma, Shunichi
   Shulman, Gerald I.
   Abel, E. Dale
   Goldberg, Ira J.
TI PPARγ-induced cardiolipotoxicity in mice is ameliorated by PPARα
   deficiency despite increases in fatty acid oxidation
SO JOURNAL OF CLINICAL INVESTIGATION
LA English
DT Article
ID ISCHEMIC-HEART-DISEASE; CHAIN ACYL-COA; ADIPOSE TRIGLYCERIDE LIPASE;
   PROTEIN-DISULFIDE-ISOMERASE; LIPOTOXIC CARDIOMYOPATHY;
   LIPID-ACCUMULATION; DIABETIC CARDIOMYOPATHY; INSULIN-RESISTANCE; FLUID
   RETENTION; HEPATIC STEATOSIS
AB Excess lipid accumulation in the heart is associated with decreased cardiac function in humans and in animal models. The reasons are unclear, but this is generally believed to result from either toxic effects of intracellular lipids or excessive fatty acid oxidation (FAO). PPAR gamma expression is increased in the hearts of humans with metabolic syndrome, and use of PPAR gamma agonists is associated with heart failure. Here, mice with dilated cardiomyopathy due to cardiomyocyte PPAR gamma overexpression were crossed with PPAR alpha-deficient mice. Surprisingly, this cross led to enhanced expression of several PPAR-regulated genes that mediate fatty acid (FA) uptake/oxidation and triacylglycerol (TAG) synthesis. Although FA oxidation and TAG droplet size were increased, heart function was preserved and survival improved. There was no marked decrease in cardiac levels of triglyceride or the potentially toxic lipids diacylglycerol (DAG) and ceramide. However, long-chain FA coenzyme A (LCCoA) levels were increased, and acylcarnitine content was decreased. Activation of PKC alpha and PKC delta, apoptosis, ROS levels, and evidence of endoplasmic reticulum stress were also reduced. Thus, partitioning of lipid to storage and oxidation can reverse cardiolipotoxicity despite increased DAG and ceramide levels, suggesting a role for other toxic intermediates such as acylcarnitines in the toxic effects of lipid accumulation in the heart.
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   [Tuinei, Joseph; Abel, E. Dale] Univ Utah, Div Endocrinol Metab & Diabet, Salt Lake City, UT USA.
   [Tuinei, Joseph; Abel, E. Dale] Univ Utah, Program Mol Med, Salt Lake City, UT USA.
   [Arai, Kotaro; Homma, Shunichi] Columbia Univ, Dept Med, Div Cardiol, New York, NY 10032 USA.
   [Hamai, Hiroko] Columbia Univ, Dept Pathol & Cell Biol, New York, NY 10032 USA.
   [Shulman, Gerald I.] Yale Univ, Sch Med, Dept Med, New Haven, CT 06510 USA.
C3 Columbia University; Utah System of Higher Education; University of
   Utah; Utah System of Higher Education; University of Utah; Columbia
   University; Columbia University; Yale University
RP Goldberg, IJ (corresponding author), Columbia Univ, Dept Med, Div Prevent Med & Nutr, 630 W 168th St,PH10-305, New York, NY 10032 USA.
EM ijg3@columbia.edu
RI Shulman, Gerald/P-7176-2019
OI Abel, E. Dale/0000-0001-5290-0738; Shulman, Gerald/0000-0003-1529-5668
FU National Heart, Lung, and Blood Institute [HL45095, HL73029, P50
   HL077113, U01HL087947]
FX We thank K.G. Bharadwaj, H. Jiang, and L. Liu for help with the kinetic
   studies, PCR, and measurement of ceramide and DAG; and Jamie Soto for
   help with mitochondrial analyses. These studies were supported by grants
   HL45095, HL73029, P50 HL077113, and U01HL087947 from the National Heart,
   Lung, and Blood Institute.
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NR 86
TC 134
Z9 143
U1 0
U2 12
PU AMER SOC CLINICAL INVESTIGATION INC
PI ANN ARBOR
PA 2015 MANCHESTER RD, ANN ARBOR, MI 48104 USA
SN 0021-9738
EI 1558-8238
J9 J CLIN INVEST
JI J. Clin. Invest.
PD OCT
PY 2010
VL 120
IS 10
BP 3443
EP 3454
DI 10.1172/JCI40905
PG 12
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 657DN
UT WOS:000282393200009
PM 20852389
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Takata, H
   Ikeda, Y
   Suehiro, T
   Ishibashi, A
   Inoue, M
   Kumon, Y
   Terada, Y
AF Takata, Hiroshi
   Ikeda, Yukio
   Suehiro, Tadashi
   Ishibashi, Ayako
   Inoue, Mari
   Kumon, Yoshitaka
   Terada, Yoshio
TI High Glucose Induces Transactivation of the α2-HS Glycoprotein Gene
   Through the ERK1/2 Signaling Pathway
SO JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
LA English
DT Article
DE Alpha2-Heremans Schmid glycoprotein; AHSG; Fetuin-A; High glucose;
   Transcription
ID RECEPTOR TYROSINE KINASE; CORONARY-HEART-DISEASE; INSULIN-RESISTANCE;
   METABOLIC SYNDROME; SUSCEPTIBILITY LOCUS; OXIDATIVE STRESS; HEPG2 CELLS;
   FETUIN-A; INHIBITOR; FRUCTOSE
AB Aim: Alpha-2-Heremans Schmid glycoprotein (AHSG), also known as fetuin-A, is secreted from the liver and inhibits tyrosine kinase activity of the insulin receptor. Hyperglycemia in type 2 diabetes is not only a secondary manifestation of insulin resistance, but could also be responsible for directly inducing insulin resistance in target tissues. In this study, we examined the effect of high glucose (HG) on AHSG gene transcription in the human hepatoma cell line HepG2.
   Methods: AHSG transcriptional activity and protein expression were evaluated using reporter gene assays and Western blot analysis, respectively.
   Results: D-glucose, but not L-glucose or mannitol, dose-dependently enhanced AHSG promoter activity. HG (25 mM) also increased AHSG protein expression. No protein kinase C inhibitors (bisindolylmaleimide, Ro-31-8220), an inhibitor of hexosamine biosynthesis pathway (6-diazo-5-oxo-L-norleucine), or a superoxide radical scavenger (tempol) affected HG-induced transactivation. MAPK/ERK kinase inhibitors (PD98059, U0126), but not the JNK inhibitor (SP600125) or p38 inhibitor (SB203580), significantly inhibited promoter activation by HG.
   Conclusion: Our data suggest that HG enhances AHSG transcription through activation of the ERK1/2 signaling pathway. Increased AHSG expression in the liver may be a cause of glucose toxicity in the diabetic state.
C1 [Takata, Hiroshi; Ikeda, Yukio; Suehiro, Tadashi; Ishibashi, Ayako; Inoue, Mari; Kumon, Yoshitaka; Terada, Yoshio] Kochi Univ, Dept Endocrinol Metab & Nephrol, Kochi Med Sch, Kochi 7838505, Japan.
C3 Kochi University
RP Ikeda, Y (corresponding author), Kochi Univ, Dept Endocrinol Metab & Nephrol, Kochi Med Sch, Oko Cho, Kochi 7838505, Japan.
EM ikeday@kochi-u.ac.jp
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NR 28
TC 57
Z9 64
U1 0
U2 7
PU JAPAN ATHEROSCLEROSIS SOC
PI TOKYO
PA NICHINAI-KAIKAN B1, 3-28-8 HONGO BUNKYO-KU, TOKYO, 113-0033, JAPAN
SN 1340-3478
EI 1880-3873
J9 J ATHEROSCLER THROMB
JI J. Atheroscler. Thromb.
PY 2009
VL 16
IS 4
BP 448
EP 456
DI 10.5551/jat.No950
PG 9
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 493RF
UT WOS:000269754900017
PM 19672022
OA hybrid
DA 2025-06-11
ER

PT J
AU Palinski, W
   Yamashita, T
   Freigang, S
   Napoli, C
AF Palinski, Wulf
   Yamashita, Tomoya
   Freigang, Stefan
   Napoli, Claudio
TI Developmental programming: Maternal hypercholesterolemia and immunity
   influence susceptibility to atherosclerosis
SO NUTRITION REVIEWS
LA English
DT Article; Proceedings Paper
CT Conference on Living Well to 100 - Is Inflammation Central to Aging
CY NOV, 2006
CL Tufts Univ, Boston, MA
HO Tufts Univ
DE adaptive immunity; atherosclerosis; developmental programming;
   inflammation; immunomodulation; maternal hypercholesterolemia; oxidative
   stress
ID LOW-DENSITY-LIPOPROTEIN; RECEPTOR-DEFICIENT MICE; ADULT LIFE;
   CARDIOVASCULAR-DISEASE; OXIDATIVE MODIFICATION; PREGNANCY INFLUENCE;
   GENE-EXPRESSION; FETAL ORIGINS; HEART-DISEASE; BIRTH-WEIGHT
AB It is increasingly recognized that the in utero environment is an important determinant of adult disease, and extensive epidemiological evidence links dysmetabolic conditions during pregnancy with increased hypertension, cardiovascular disease, and diabetes later in life. The original Barker Hypothesis focused on low birth weight as the primary indicator of postnatal risk, but low birth weight may arise from other, nonmetabolic conditions. This has impeded the identification of developmental programming mechanisms. More recently, the focus has shifted to the impact of specific maternal risk factors, such as obesity, metabolic syndrome, and diabetes, on cardiovascular risk in offspring. Inflammation plays a central role in these maternal conditions as well as in offspring atherogenesis, and two key factors that influence inflammation, maternal hypercholesterolemia and maternal immune mechanisms, have been shown to affect the developmental programming of atherosclerosis. Maternal hypercholesterolemia in pregnancy, even if only temporary, is associated with increased fatty streak formation in human fetal arteries and accelerated progression of atherosclerosis in normocholesterolemic children. Conversely, immunization of experimental animals with oxidized low-density lipoprotein cholesterol, an antigen prevalent in atherosclerotic lesions, inhibits the progression of atherosclerosis in the offspring of hypercholesterolemic mothers. These findings indicate it is possible, in principle, to program postnatal immune responses and to reduce atherosclerosis, and potentially other immunomodulated diseases, by targeted maternal immunomodulation.
C1 [Palinski, Wulf] Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA.
   [Yamashita, Tomoya] Kobe Univ, Sch Med, Dept Med, Kobe, Hyogo 650, Japan.
   [Freigang, Stefan] Scripps Res Inst, Dept Immunol, La Jolla, CA USA.
   [Napoli, Claudio] Univ Naples Federico 2, Dept Gen Pathol, Div Clin Pathol, Naples, Italy.
   [Napoli, Claudio] Univ Naples Federico 2, Dept Gen Pathol, Excellence Res Ctr Cardiovasc Dis, Naples, Italy.
C3 University of California System; University of California San Diego;
   Kobe University; Scripps Research Institute; University of Naples
   Federico II; University of Naples Federico II
RP Palinski, W (corresponding author), Univ Calif San Diego, Dept Med 0682, 9500 Gilman Dr, La Jolla, CA 92093 USA.
EM wpalinski@ucsd.edu
RI Freigang, Stefan/A-8682-2013; Palinski, Wulf/KPA-6104-2024
OI Palinski, Wulf/0000-0002-5113-0169; Yamashita,
   Tomoya/0000-0003-0267-3842; Napoli, Claudio/0000-0002-5455-555X;
   Freigang, Stefan/0000-0003-4438-7828
FU NHLBI NIH HHS [HL-067792, HL-56989] Funding Source: Medline
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NR 34
TC 39
Z9 45
U1 0
U2 9
PU BLACKWELL PUBLISHING
PI OXFORD
PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND
SN 0029-6643
J9 NUTR REV
JI Nutr. Rev.
PD DEC
PY 2007
VL 65
IS 12
BP S182
EP S187
DI 10.1301/nr.2007.dec.S182-S187
PN 2
PG 6
WC Nutrition & Dietetics
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 245FL
UT WOS:000251920400010
PM 18240546
DA 2025-06-11
ER

PT J
AU George, BT
   Jhancy, M
   Dube, R
   Kar, SS
   Annamma, LM
AF George, Biji Thomas
   Jhancy, Malay
   Dube, Rajani
   Kar, Subhranshu Sekhar
   Annamma, Lovely Muthiah
TI The Molecular Basis of Male Infertility in Obesity: A Literature Review
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE insulin resistance; reproductive hormone; adipokine; leptin;
   adiponectin; resistin; sirtuin; epigenetic; infertility; obesity;
   molecular basis
ID GHRELIN SUPPRESSES SECRETION; GLUCAGON-LIKE PEPTIDE-1; INHIBIN-B LEVELS;
   OXIDATIVE STRESS; ADIPOSE-TISSUE; REDUCED TESTOSTERONE; METABOLIC
   SYNDROME; ADIPONECTIN LEVELS; GENE-EXPRESSION; MALE-FERTILITY
AB The rising incidence of obesity has coincided with rising levels of poor reproductive outcomes. The molecular basis for the association of infertility in obese males is now being explained through various mechanisms. Insulin resistance, hyperglycemia, and changes in serum and gonadal concentrations of adipokines, like leptin, adiponectin, resistin, and ghrelin have been implicated as causes of male infertility in obese males. The effects of obesity and hypogonadism form a vicious cycle whereby dysregulation of the hypothalamic-pituitary-testicular axis-due to the effect of the release of multiple mediators, thus decreasing GnRH release from the hypothalamus-causes decreases in LH and FSH levels. This leads to lower levels of testosterone, which further increases adiposity because of increased lipogenesis. Cytokines such as TNF-alpha and interleukins, sirtuins, and other inflammatory mediators like reactive oxygen species are known to affect fertility in obese male adults. There is evidence that parental obesity can be transferred through subsequent generations to offspring through epigenetic marks. Thus, negative expressions like obesity and infertility have been linked to epigenetic marks being altered in previous generations. The interesting aspect is that these epigenetic expressions can be reverted by removing the triggering factors. These positive modifications are also transmitted to subsequent generations.
C1 [George, Biji Thomas] RAKMHSU, RAK Coll Med Sci, Dept Surg, POB 11172, Ras Al Khaymah, U Arab Emirates.
   [Jhancy, Malay; Kar, Subhranshu Sekhar] RAKMHSU, RAK Coll Med Sci, Dept Pediat, POB 11172, Ras Al Khaymah, U Arab Emirates.
   [Dube, Rajani] RAKMHSU, RAK Coll Med Sci, Dept Obstet & Gynecol, POB 11172, Ras Al Khaymah, U Arab Emirates.
   [Annamma, Lovely Muthiah] Ajman Univ, Dept Clin Sci, POB 346, Ajman, U Arab Emirates.
C3 Ajman University
RP George, BT (corresponding author), RAKMHSU, RAK Coll Med Sci, Dept Surg, POB 11172, Ras Al Khaymah, U Arab Emirates.
EM biji@rakmhsu.ac.ae; jhancy@rakmhsu.ac.ae; rajani.dube@rakmhsu.ac.ae;
   subhranshu.kar@rakmhsu.ac.ae; l.annamma@ajman.ac.ae
RI George, Biji/AAR-1418-2021; Malay, Jhancy/KLE-2572-2024; Dube,
   Rajani/AAX-8080-2020; Kar, Subhranshu Sekhar/M-7864-2015
OI Dube, Rajani/0000-0002-1539-6162; Kar, Subhranshu
   Sekhar/0000-0002-9379-7447; Malay, Jhancy/0000-0002-2336-0872; George,
   Biji Thomas/0000-0001-5029-7779
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NR 106
TC 16
Z9 16
U1 1
U2 8
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD JAN
PY 2024
VL 25
IS 1
AR 179
DI 10.3390/ijms25010179
PG 16
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA EQ7J6
UT WOS:001140452100001
PM 38203349
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Francekovic, P
   Gliemann, L
AF Francekovic, Paula
   Gliemann, Lasse
TI Endothelial Glycocalyx Preservation-Impact of Nutrition and Lifestyle
SO NUTRIENTS
LA English
DT Review
DE endothelial glycocalyx; lifestyle diseases; cardiovascular health;
   obesity; diabetes; hypertension; nutrition therapy; Mediterranean diet;
   vitamin D; dietary sulfur; dietary nitrates; mechanotransduction;
   endotoxemia; intermittent fasting
ID LOW-DENSITY-LIPOPROTEIN; GLYCATION END-PRODUCTS; NF-KAPPA-B;
   BLOOD-PRESSURE; VITAMIN-D; DIETARY NITRATE; SHEAR-STRESS;
   CARDIOVASCULAR-DISEASE; VASCULAR ENDOTHELIUM; INSULIN-RESISTANCE
AB The endothelial glycocalyx (eGC) is a dynamic hair-like layer expressed on the apical surface of endothelial cells throughout the vascular system. This layer serves as an endothelial cell gatekeeper by controlling the permeability and adhesion properties of endothelial cells, as well as by controlling vascular resistance through the mediation of vasodilation. Pathogenic destruction of the eGC could be linked to impaired vascular function, as well as several acute and chronic cardiovascular conditions. Defining the precise functions and mechanisms of the eGC is perhaps the limiting factor of the missing link in finding novel treatments for lifestyle-related diseases such as atherosclerosis, type 2 diabetes, hypertension, and metabolic syndrome. However, the relationship between diet, lifestyle, and the preservation of the eGC is an unexplored territory. This article provides an overview of the eGC's importance for health and disease and describes perspectives of nutritional therapy for the prevention of the eGC's pathogenic destruction. It is concluded that vitamin D and omega-3 fatty acid supplementation, as well as healthy dietary patterns such as the Mediterranean diet and the time management of eating, might show promise for preserving eGC health and, thus, the health of the cardiovascular system.
C1 [Francekovic, Paula; Gliemann, Lasse] Univ Copenhagen, Dept Nutr Exercise & Sports, Univ Pk 13, DK-2100 Copenhagen, Denmark.
C3 University of Copenhagen
RP Gliemann, L (corresponding author), Univ Copenhagen, Dept Nutr Exercise & Sports, Univ Pk 13, DK-2100 Copenhagen, Denmark.
EM gliemann@nexs.ku.dk
RI Gliemann, Lasse/P-6273-2014
OI Gliemann, Lasse/0000-0002-0382-2523
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NR 126
TC 7
Z9 7
U1 0
U2 3
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD MAY 31
PY 2023
VL 15
IS 11
AR 2573
DI 10.3390/nu15112573
PG 20
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA I9HH4
UT WOS:001005812600001
PM 37299535
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Palma, R
   Pronio, A
   Romeo, M
   Scognamiglio, F
   Ventriglia, L
   Ormando, VM
   Lamazza, A
   Pontone, S
   Federico, A
   Dallio, M
AF Palma, Rossella
   Pronio, Annamaria
   Romeo, Mario
   Scognamiglio, Flavia
   Ventriglia, Lorenzo
   Ormando, Vittorio Maria
   Lamazza, Antonietta
   Pontone, Stefano
   Federico, Alessandro
   Dallio, Marcello
TI The Role of Insulin Resistance in Fueling NAFLD Pathogenesis: From
   Molecular Mechanisms to Clinical Implications
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Review
DE non-alcoholic fatty liver disease; insulin resistance; precision
   medicine
ID NONALCOHOLIC FATTY LIVER; INTESTINAL BACTERIAL OVERGROWTH;
   GLUCOSE-HOMEOSTASIS; HEPATIC STEATOSIS; RECEPTOR-ALPHA; GUT MICROBIOME;
   CONFERS SUSCEPTIBILITY; WIDE ASSOCIATION; OBETICHOLIC ACID; DISEASE
AB Non-alcoholic fatty liver disease (NAFLD) represents a predominant hepatopathy that is rapidly becoming the most common cause of hepatocellular carcinoma worldwide. The close association with metabolic syndrome's extrahepatic components has suggested the nature of the systemic metabolic-related disorder based on the interplay between genetic, nutritional, and environmental factors, creating a complex network of yet-unclarified pathogenetic mechanisms in which the role of insulin resistance (IR) could be crucial. This review detailed the clinical and pathogenetic evidence involved in the NAFLD-IR relationship, presenting both the classic and more innovative models. In particular, we focused on the reciprocal effects of IR, oxidative stress, and systemic inflammation on insulin-sensitivity disruption in critical regions such as the hepatic and the adipose tissue, while considering the impact of genetics/epigenetics on the regulation of IR mechanisms as well as nutrients on specific insulin-related gene expression (nutrigenetics and nutrigenomics). In addition, we discussed the emerging capability of the gut microbiota to interfere with physiological signaling of the hormonal pathways responsible for maintaining metabolic homeostasis and by inducing an abnormal activation of the immune system. The translation of these novel findings into clinical practice could promote the expansion of accurate diagnostic/prognostic stratification tools and tailored pharmacological approaches.
C1 [Palma, Rossella; Pronio, Annamaria] Sapienza Univ Rome, Dept Gen Surg & Surg Specialties Paride Stefanini, I-00161 Rome, Italy.
   [Romeo, Mario; Scognamiglio, Flavia; Ventriglia, Lorenzo; Federico, Alessandro; Dallio, Marcello] Univ Campania Luigi Vanvitelli, Dept Precis Med, Hepatogastroenterol Div, Piazza Luigi Miraglia 2, I-80138 Naples, Italy.
   [Ormando, Vittorio Maria] AORN San Giuseppe Moscati, Gastroenterol & Endoscopy Unit, I-83100 Avellino, Italy.
   [Lamazza, Antonietta] Sapienza Univ Rome, Dept Surg Pietro Valdoni, I-00161 Rome, Italy.
   [Pontone, Stefano] Sapienza Univ Rome, Dept Surg Sci, I-00161 Rome, Italy.
C3 Sapienza University Rome; Universita della Campania Vanvitelli; San
   Giuseppe Moscati Hospital; Sapienza University Rome; Sapienza University
   Rome
RP Palma, R (corresponding author), Sapienza Univ Rome, Dept Gen Surg & Surg Specialties Paride Stefanini, I-00161 Rome, Italy.
EM rossellapa1ma89@gmail.com; annamaria.pronio@uniroma1.it;
   mario.romeo@unicampania.it; flavia.scognamiglio@unicampania.it;
   lorenzo.ventriglia@unicampania.it; ormandov@yahoo.it;
   antoniettalamazza@uniroma1.it; stefano.pontone@uniroma1.it;
   alessandro.federico@unicampania.it; marcello.dallio@unicampania.it
RI Dallio, Marcello/ABG-7693-2020; Pontone, Stefano/H-7681-2019; Palma,
   Rossella/ADC-1156-2022; Federico, Alessandro/AAB-3893-2019
OI Ventriglia, Lorenzo/0000-0002-2947-431X; Pontone,
   Stefano/0000-0001-7148-3220; DALLIO, MARCELLO/0000-0003-4153-815X;
   Romeo, Mario/0000-0002-2970-9019; Federico,
   Alessandro/0000-0002-0885-0793; Scognamiglio,
   Flavia/0009-0004-4215-9068; Ormando, Vittorio Maria/0000-0003-4481-755X
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NR 170
TC 38
Z9 41
U1 2
U2 17
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD JUL
PY 2022
VL 11
IS 13
AR 3649
DI 10.3390/jcm11133649
PG 23
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 2V9RO
UT WOS:000824173900001
PM 35806934
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Li, J
   Liu, GC
   Zhang, F
   Zhang, ZW
   Xu, YQ
   Li, Q
AF Li, Jie
   Liu, Guocai
   Zhang, Feng
   Zhang, Zhiwen
   Xu, Yuqiao
   Li, Qing
TI Role of glycoprotein 78 and cidec in hepatic steatosis
SO MOLECULAR MEDICINE REPORTS
LA English
DT Article
DE glycoprotein 78; hepatic cell; steatosis; lipids; cell death-inducing
   DFFA-like effector c
ID NONALCOHOLIC FATTY LIVER; E3 UBIQUITIN LIGASE; HMG COA REDUCTASE;
   METABOLIC SYNDROME; DEFICIENT MICE; CELL-DEATH; ER STRESS; DISEASE;
   PROTEIN; FSP27
AB Hepatic glycoprotein (gp78), a membrane-anchored E3 ubiquitin ligase, has been reported to be involved in regulating lipid and energy metabolism in animals, and cell death-inducing DFFA-like effector c (cidec) has emerged as an important regulator of metabolism, which has been implicated in the process of fat differentiation. Nonalcoholic fatty liver disease is a metabolic disorder associated with hepatic steatosis. In the present study, to investigate the role of gp78 and cidec in hepatic steatosis, an in vitro cell culture model of hepatic steatosis was established, using the AML12 mouse hepatocyte cell line to assess the protein expression of gp78. The results of Oil Red O staining, phase contrast microscopy and triglyceride content detection experiments indicated that the overexpression of gp78 induced lipid accumulation, whereas gp78-knockdown led to a reduction in lipid accumulation in the AML12 cells. The increased expression of gp78 was associated with steatosis. The expression of cidec was consistent with gp78, and the colocalization of gp78 and cidec was observed on the surface of lipid droplets using immunofluorescence analysis. Furthermore, an interaction between gp78 and cidec was detected using coimmunoprecipitation analysis, and this interaction promoted lipid accumulation. Based on these data, it was hypothesized that gp78 is a regulator of hepatic steatosis, and that it may be a putative molecular mediator in metabolic diseases.
C1 [Li, Jie; Zhang, Feng; Zhang, Zhiwen; Xu, Yuqiao; Li, Qing] Fourth Mil Med Univ, Xijing Hosp, Dept Pathol, State Key Lab Canc Biol,Basic Med Coll, 169 Changle West Rd, Xian 710032, Shaanxi, Peoples R China.
   [Liu, Guocai] Chinese PLA, Hosp 273, Dept Internal Med 3, Korla 84100, Xinjiang, Peoples R China.
C3 Air Force Medical University
RP Xu, YQ; Li, Q (corresponding author), Fourth Mil Med Univ, Xijing Hosp, Dept Pathol, State Key Lab Canc Biol,Basic Med Coll, 169 Changle West Rd, Xian 710032, Shaanxi, Peoples R China.
EM yuqiaoxu@fmmu.edu.cn; liqing@fmmu.edu.cn
RI Zhang, Zhiwen/ABI-4441-2022
FU National Natural Science Foundation of China [81170798, 81000171,
   31400722]
FX This study was supported by Grants from National Natural Science
   Foundation of China (grant nos. 81170798, 81000171 and 31400722.).
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NR 32
TC 7
Z9 7
U1 0
U2 7
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1791-2997
EI 1791-3004
J9 MOL MED REP
JI Mol. Med. Rep.
PD AUG
PY 2017
VL 16
IS 2
BP 1871
EP 1877
DI 10.3892/mmr.2017.6834
PG 7
WC Oncology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Research & Experimental Medicine
GA EZ9VX
UT WOS:000405079300116
PM 28656280
OA Green Submitted, Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Huerta, AE
   Prieto-Hontoria, PL
   Fernández-Galilea, M
   Escoté, X
   Martínez, JA
   Moreno-Aliaga, MJ
AF Huerta, Ana E.
   Prieto-Hontoria, Pedro L.
   Fernandez-Galilea, Marta
   Escote, Xavier
   Alfredo Martinez, J.
   Moreno-Aliaga, Maria J.
TI Effects of dietary supplementation with EPA and/or -lipoic acid on
   adipose tissue transcriptomic profile of healthy overweight/obese women
   following a hypocaloric diet
SO BIOFACTORS
LA English
DT Article
DE microarray; n3-PUFAs; gene expression; adipose tissue; obesity
ID ENDOPLASMIC-RETICULUM STRESS; POLYUNSATURATED FATTY-ACIDS;
   EICOSAPENTAENOIC ACID; INSULIN SENSITIVITY; GENE-EXPRESSION; METABOLIC
   SYNDROME; WEIGHT-LOSS; OBESITY; INFLAMMATION; MACROPHAGES
AB In obesity, the increment of adiposity levels disrupts the whole body homeostasis, promoting an over production of oxidants and inflammatory mediators. The current study aimed to characterize the transcriptomic changes promoted by supplementation with eicosapentaenoic acid (EPA, 1.3 g/day), -lipoic acid (0.3 g/day), or both (EPA+-lipoic acid, 1.3 g/day+0.3 g/day) in subcutaneous abdominal adipose tissue from overweight/obese healthy women, who followed a hypocaloric diet (30% of total energy expenditure) during ten weeks, by using a microarray approach. At the end of the intervention, a total of 33,297 genes were analyzed using Affymetrix GeneChip arrays. EPA promoted changes in extracellular matrix remodeling gene expression, besides a rise of genes associated with either chemotaxis or wound repair. -Lipoic acid decreased expression of genes related with cell adhesion and inflammation. Furthermore, -lipoic acid, especially in combination with EPA, upregulated the expression of genes associated with lipid catabolism while downregulated genes involved in lipids storage. Together, all these data suggest that some of the metabolic effects of EPA and -lipoic acid could be related to their regulatory actions on adipose tissue metabolism. (c) 2016 BioFactors, 43(1):117-131, 2017
C1 [Huerta, Ana E.; Prieto-Hontoria, Pedro L.; Fernandez-Galilea, Marta; Escote, Xavier; Alfredo Martinez, J.; Moreno-Aliaga, Maria J.] Univ Navarra, Dept Nutr Food Sci & Physiol, C Irunlarrea 1, Pamplona 31008, Spain.
   [Huerta, Ana E.; Escote, Xavier; Alfredo Martinez, J.; Moreno-Aliaga, Maria J.] Univ Navarra, Ctr Nutr Res, Pamplona, Spain.
   [Alfredo Martinez, J.; Moreno-Aliaga, Maria J.] Inst Hlth Carlos III ISCIII, Spanish Biomed Res Ctr Physiopathol Obes & Nutr C, Madrid, Spain.
   [Alfredo Martinez, J.; Moreno-Aliaga, Maria J.] Navarra Inst Hlth Res IdiSNA, Pamplona, Spain.
   [Prieto-Hontoria, Pedro L.] Univ SEK, Fac Hlth & Phys Act Sci, Santiago, Chile.
   [Fernandez-Galilea, Marta] Pontificia Univ Catolica Chile, Sch Med, Dept Nutr Diabet & Metab, Santiago, Chile.
C3 University of Navarra; University of Navarra; University of Navarra;
   Universidad Internacional SEK; Pontificia Universidad Catolica de Chile
RP Moreno-Aliaga, MJ (corresponding author), Univ Navarra, Dept Nutr Food Sci & Physiol, C Irunlarrea 1, Pamplona 31008, Spain.
EM mjmoreno@unav.es
RI Romo Hualde, Ana/G-2428-2016; Fernandez-Galilea, Marta/AAA-2635-2019;
   Martínez, J./K-8709-2014; Escote, Xavier/AAC-6335-2019; Moreno-Aliaga,
   Maria J./M-7015-2018
OI Huerta Hernandez, Ana Elsa/0000-0003-1911-5310; Fernandez-Galilea,
   Marta/0000-0002-4822-3188; Moreno-Aliaga, Maria J./0000-0002-2018-6434
FU Ministry of Economy and Competitiveness from the Government of Spain
   [AGL 2009-10873/ALI, BFU2012-36089]; Navarra Government (Department of
   Health) [67/2015]; University of Navarra-Spain; CIBERobn; Asociacion de
   Amigos de la Universidad de Navarra
FX We thank to the Ministry of Economy and Competitiveness from the
   Government of Spain (ref. AGL 2009-10873/ALI and BFU2012-36089), to
   Navarra Government (Department of Health ref. 67/2015), to the Special
   Research Line of "Nutrition, Obesity and Health" from the University of
   Navarra-Spain and to CIBERobn for the grants received. AE Huerta was
   supported by a predoctoral grant from "Asociacion de Amigos de la
   Universidad de Navarra." EPA and sunflower oil capsules were provided by
   Solutex (R) (Madrid, Spain). Solutex had no role in the study design,
   data collection, analysis and interpretation, or writing of the
   manuscript. The authors have declared no conflict of interest.
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NR 58
TC 22
Z9 22
U1 0
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0951-6433
EI 1872-8081
J9 BIOFACTORS
JI Biofactors
PD JAN-FEB
PY 2017
VL 43
IS 1
BP 117
EP 131
DI 10.1002/biof.1317
PG 15
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA EL8ZQ
UT WOS:000394909300010
PM 27507611
DA 2025-06-11
ER

PT J
AU Emed, LGM
   Passaglia, DG
   Guerios, ST
   Joao, PGD
   Moser, AIS
   Abdalla, DSP
   Guarita-Souza, LC
   Mikilita, ES
   Baena, CP
   da Costa, ABBA
   Faria-Neto, JR
AF Emed, Luiz Gustavo Marin
   Passaglia, Daniela Gunther
   Guerios, Surya T.
   Joao, Paula G. D.
   Moser, Andre I. S.
   Abdalla, Dulcineia S. P.
   Guarita-Souza, Luis Cesar
   Mikilita, Emanuella Stella
   Baena, Cristina Pellegrino
   Brenner Affonso da Costa, Ana Beatriz
   Faria-Neto, Jose Rocha
TI Acute modification in plasma lipid levels in ultramarathon runners
SO JOURNAL OF SPORTS SCIENCES
LA English
DT Article
DE Physical activity; physical endurance; lipoproteins; oxidised low
   density lipoprotein
ID OXIDATIVE MODIFICATION; MYOCARDIAL-INFARCTION; METABOLIC SYNDROME;
   PARTICLE-SIZE; RISK-FACTORS; 52 COUNTRIES; LIPOPROTEIN; EXERCISE; LDL;
   APOLIPOPROTEINS
AB We aimed to evaluate the effects of a 24-h ultramarathon, an aerobic test of high physical load, on lipid profile and apolipoproteins B (ApoB) and A1 (ApoA1) levels, minimally modified low-density lipoprotein (LDL), and oxidised LDL. Prospective evaluation of 16 male athletes who participated in an ultramarathon run, where the objective was to run the greatest distance possible in 24h. Fourteen participants completed the run. The mean distance achieved was 133.1km (maximum of 169.6km). There was a trend in reduction of triglycerides and total cholesterol (P=0.06 and 0.05, respectively), without significant modifications in high-density lipoprotein, LDL and ApoA1 levels (P=0.16; 0.55 and 0.67). There was a marked reduction in ApoB levels (P<0.001), correlated directly to the distance covered (Pearson R=0.68). Accordingly, an increase in the LDL/ApoB ratio was observed. The stress of this physical activity was not associated to an increase in minimally modified LDL or oxidised LDL. Lipid profile levels were not acutely altered by prolonged physical activity. Similarly, there was no evidence of greater oxidation of LDL over a 24-h period of physical activity. The reduction in ApoB was directly proportional to the distance covered, suggesting an acute positive change in phenotype of LDL molecules.
C1 [Emed, Luiz Gustavo Marin; Passaglia, Daniela Gunther; Guerios, Surya T.; Joao, Paula G. D.; Moser, Andre I. S.; Guarita-Souza, Luis Cesar; Mikilita, Emanuella Stella; Baena, Cristina Pellegrino; Brenner Affonso da Costa, Ana Beatriz; Faria-Neto, Jose Rocha] Pontificia Univ Catolica Parana, Sch Med, Curitiba, Parana, Brazil.
   [Emed, Luiz Gustavo Marin; Guarita-Souza, Luis Cesar] Hosp Cardiol Costantini, Curitiba, Parana, Brazil.
   [Abdalla, Dulcineia S. P.] Univ Sao Paulo, Fac Ciencias Farmaceut, Sao Paulo, Brazil.
C3 Pontificia Universidade Catolica do Parana; Universidade de Sao Paulo
RP Faria-Neto, JR (corresponding author), Pontificia Univ Catolica Parana, Sch Med, Rua Imaculada Conceicao 1155, BR-80215901 Curitiba, Parana, Brazil.
EM jose.faria@pucpr.br
RI Costa, Ana/GON-5151-2022; Neto, Jose/G-7559-2012; Baena,
   Cristina/W-6039-2019
OI Baena, Cristina Pellegrino/0000-0002-5822-6622
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NR 40
TC 10
Z9 11
U1 0
U2 7
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0264-0414
EI 1466-447X
J9 J SPORT SCI
JI J. Sports Sci.
PD SEP
PY 2016
VL 34
IS 17
BP 1657
EP 1661
DI 10.1080/02640414.2015.1130237
PG 5
WC Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Sport Sciences
GA DP7YE
UT WOS:000378714300009
PM 26710938
DA 2025-06-11
ER

PT J
AU Kianoush, S
   Al Rifai, M
   Whelton, SP
   Shaya, GE
   Bush, AL
   Graham, G
   Wong, ND
   Blaha, MJ
AF Kianoush, Sina
   Al Rifai, Mahmoud
   Whelton, Seamus P.
   Shaya, Gabriel E.
   Bush, Aaron L.
   Graham, Garth
   Wong, Nathan D.
   Blaha, Michael J.
TI Stratifying cardiovascular risk in diabetes: The role of
   diabetes-related clinical characteristics and imaging
SO JOURNAL OF DIABETES AND ITS COMPLICATIONS
LA English
DT Review
DE Coronary heart disease; Cardiovascular disease; Risk assessment;
   Coronary artery calcium; Primary prevention; Statins
ID CORONARY-ARTERY CALCIUM; AMERICAN-HEART-ASSOCIATION; OBSTRUCTIVE
   SLEEP-APNEA; FATTY LIVER-DISEASE; ALL-CAUSE MORTALITY; METABOLIC
   SYNDROME; ASYMPTOMATIC INDIVIDUALS; CEREBROVASCULAR EVENTS; ERECTILE
   DYSFUNCTION; SCIENTIFIC STATEMENT
AB Diabetes is a major coronary heart disease (CHD) and cardiovascular disease (CVD) risk factor and has traditionally been classified as a CHD risk equivalent. CVD risk, however, is heterogeneous among diabetic patients and thus further evaluation is warranted before initiating or titrating preventive pharmacotherapy. Prognostic clinical characteristics of diabetes such as age of onset, duration, and severity of diabetes, as well as concomitant cardiometabolic factors account for much of the variability in CHD and CVD risk. This heterogeneity can also be evaluated directly using non-invasive imaging, which allows for a more individualized risk assessment in order to minimize both under and overtreatment. In this paper, we review guideline recommendations for atherosclerotic CVD risk assessment driving the use of statins or aspirin for certain subgroups of patients with diabetes. We further discuss imaging techniques, such as stress myocardial perfusion imaging, coronary computed tomography angiography, and coronary artery calcium (CAC) scoring that can guide the decision to treat high-risk patients. Among imaging tests, current guidelines consider CAC scoring the most appropriate risk stratification tool for asymptomatic individuals with diabetes that can guide initiating/intensifying or withholding the most aggressive pharmacological therapies among high-risk (CAC > 100) or low-risk (CAC = 0) individuals, respectively. (C) 2016 Elsevier Inc. All rights reserved.
C1 [Kianoush, Sina; Al Rifai, Mahmoud; Whelton, Seamus P.; Bush, Aaron L.; Blaha, Michael J.] Johns Hopkins Ciccarone Ctr Prevent Heart Dis, Baltimore, MD USA.
   [Shaya, Gabriel E.] Univ Miami, Miller Sch Med, Coral Gables, FL 33124 USA.
   [Graham, Garth] Aetna Fdn, Hartford, CT USA.
   [Graham, Garth] Univ Connecticut, Sch Med, Farmington, CT USA.
   [Wong, Nathan D.] Univ Calif Irvine, Div Cardiol, Irvine, CA USA.
   [Blaha, Michael J.] Johns Hopkins, Welch Ctr Prevent Epidemiol & Clin Res, Baltimore, MD USA.
C3 Johns Hopkins University; Johns Hopkins Medicine; University of Miami;
   University of Connecticut; University of California System; University
   of California Irvine; Johns Hopkins University
RP Blaha, MJ (corresponding author), Blalock 524 D1,600 N Wolfe St, Baltimore, MD 21287 USA.
EM skianou1@jhmi.edu; malrifa1@jhu.edu; swhelto1@jhmi.edu;
   geshaya@med.miami.edu; bush@jhmi.edu; grahamg@aetna.com; ndwong@uci.edu;
   mblaha1@jhmi.edu
FU NIH/NHLBI; American Heart Association; Aetna Foundation; FDA; Pfizer;
   Novartis; Aralez Pharmaceuticals; Luitpold Pharmaceuticals; ISIS
   Pharmaceuticals
FX The authors report no source of funding for this project. Michael J.
   Blaha declares grants from NIH/NHLBI, American Heart Association, Aetna
   Foundation, grants and personal fees from the FDA, and personal fees for
   Advisory Board work with Pfizer, Novartis, Aralez Pharmaceuticals,
   Luitpold Pharmaceuticals, and ISIS Pharmaceuticals.
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NR 75
TC 6
Z9 7
U1 0
U2 10
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1056-8727
EI 1873-460X
J9 J DIABETES COMPLICAT
JI J. Diabetes Complications
PD SEP-OCT
PY 2016
VL 30
IS 7
BP 1408
EP 1415
DI 10.1016/j.jdiacomp.2016.04.021
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA DU3GA
UT WOS:000382097600032
PM 27179751
DA 2025-06-11
ER

PT J
AU Han, K
   Hwang, E
   Park, JB
AF Han, Kyungdo
   Hwang, Eunkyung
   Park, Jun-Beom
TI Excessive Consumption of Green Tea as a Risk Factor for Periodontal
   Disease among Korean Adults
SO NUTRIENTS
LA English
DT Article
DE epidemiology; health surveys; nutrition surveys; oral health;
   periodontitis; tea
ID NATIONAL-HEALTH; OXIDATIVE STRESS; EPIGALLOCATECHIN-3-GALLATE; CAFFEINE;
   EXTRACT; HYPERTENSION; ASSOCIATIONS; POLYPHENOLS; PREVALENCE; CATECHINS
AB This study was performed to assess the relationship between the amount of green tea that is consumed and periodontitis. It is based on data obtained from the Korea National Health and Nutrition Examination Survey, conducted between 2008 and 2010. A community periodontal index equal to code 3 was defined as moderate periodontitis, and code 4 was defined as severe periodontitis (n = 16,726). Consumption of green tea less than one cup per day was associated with a decreased prevalence of periodontal disease among Korean adults. The association between the consumption of green tea and periodontal disease was independent of various potential confounding factors, such as age, sex, body mass index, smoking, drinking, exercise, metabolic syndrome, frequency of tooth brushing per day, use of secondary oral products, the number of dental examination per year, diabetes, hypertension, and white blood cell count. Adjusted odds ratio and 95% confidence interval of no consumption was 1.360 (1.156, 1.601) when participants with consumption of two times per week <= x < 7 times per week was considered as a reference. However, consumption of one or more cups per day increased the prevalence of moderate and severe periodontitis. In conclusion, excessive consumption of green tea may be considered as a risk factor for periodontal disease among Korean adults.
C1 [Han, Kyungdo] Catholic Univ Korea, Coll Med, Dept Biostat, Seoul 06591, South Korea.
   [Hwang, Eunkyung] Myongji Univ, Bangmok Coll Gen Educ, Seoul 03674, South Korea.
   [Park, Jun-Beom] Catholic Univ Korea, Coll Med, Dept Periodont, Seoul 06591, South Korea.
C3 Catholic University of Korea; Myongji University; Catholic University of
   Korea
RP Park, JB (corresponding author), Catholic Univ Korea, Coll Med, Dept Periodont, Seoul 06591, South Korea.
EM hkd917@naver.com; hwangek@mju.ac.kr; jbassoonis@yahoo.co.kr
RI Park, Jun-Beom/I-8201-2019; Han, Kyungdo/JKH-7628-2023
OI Han, Kyungdo/0000-0002-6096-1263; Hwang, Eunkyung/0000-0002-6493-7412;
   Park, Jun-Beom/0000-0002-8915-1555
FU National Research Foundation of Korea (NRF) - Ministry of Science,
   Information and Communication Technology & Future Planning
   [NRF-2014R1A1A1003106]
FX This research was supported by Basic Science Research Program through
   the National Research Foundation of Korea (NRF) funded by the Ministry
   of Science, Information and Communication Technology & Future Planning
   (NRF-2014R1A1A1003106).
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NR 42
TC 16
Z9 17
U1 0
U2 20
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JUL
PY 2016
VL 8
IS 7
AR 408
DI 10.3390/nu8070408
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA DS4QP
UT WOS:000380766200025
PM 27384581
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Blake, R
   Trounce, IA
AF Blake, Rachel
   Trounce, Ian A.
TI Mitochondrial dysfunction and complications associated with diabetes
SO BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
LA English
DT Review
DE Diabetes; Complication; Mitochondria; Oxidative phosphorylation;
   Reactive oxygen species; Mouse model
ID ACTIVATED PROTEIN-KINASE; DORSAL-ROOT GANGLIA; 3 MAJOR PATHWAYS;
   OXIDATIVE STRESS; INSULIN-RESISTANCE; ATP PRODUCTION; HYPERGLYCEMIC
   DAMAGE; VASCULAR-DISEASE; GROWTH-FACTOR; CYTOCHROME-B
AB Background: Diabetes is a metabolic syndrome that results in chronically increased blood glucose (hyperglycaemia) due to defects either in insulin secretion consequent to the loss of beta cells in the pancreas (type 1) or to loss of insulin sensitivity in target organs in the presence of normal insulin secretion (type 2). Long term hyperglycaemia can lead to a number of serious health-threatening pathologies, or complications, especially in the kidney, heart, retina and peripheral nervous system.
   Scope of review: Here we summarise the current literature on the role of the mitochondria in complications associated with diabetes, and the limitations and potential of rodent models to explore new modalities to limit complication severity.
   Major conclusions: Prolonged hyperglycaemia results in perturbation of catabolic pathways and in an overproduction of ROS by the mitochondria, which in turn may play a role in the development of diabetic complications. Furthermore, current models don't offer a comprehensive recapitulation of these complications.
   General significance: The onset of complications associated with type 1 diabetes can be varied, even with tightly controlled blood glucose levels. The potential role of inherited, mild mitochondrial dysfunction in accelerating diabetic complications, both in type I and 2 diabetes, remains unexplored. This article is part of a Special Issue entitled Frontiers of Mitochondrial Research. (C) 2013 Elsevier B.V. All rights reserved.
C1 [Trounce, Ian A.] Univ Melbourne, Royal Victorian Eye & Ear Hosp, Dept Ophthalmol, Ctr Eye Res Australia, Melbourne, Vic 3002, Australia.
   Univ Melbourne, Dept Med, St Vincents Hosp, Melbourne, Vic 3065, Australia.
C3 University of Melbourne; Centre for Eye Research Australia; Royal
   Victorian Eye & Ear Hospital; NSW Health; St Vincents Hospital Sydney;
   University of Melbourne; St Vincent's Health; St Vincent's Hospital
   Melbourne
RP Trounce, IA (corresponding author), Univ Melbourne, Royal Victorian Eye & Ear Hosp, Dept Ophthalmol, Ctr Eye Res Australia, 32 Gisborne St East, Melbourne, Vic 3002, Australia.
EM i.trounce@unimelb.edu.au
RI Trounce, Ian/F-8338-2010
OI Trounce, Ian/0000-0002-1070-8892
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NR 102
TC 141
Z9 155
U1 1
U2 38
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0304-4165
EI 1872-8006
J9 BBA-GEN SUBJECTS
JI Biochim. Biophys. Acta-Gen. Subj.
PD APR
PY 2014
VL 1840
IS 4
SI SI
BP 1404
EP 1412
DI 10.1016/j.bbagen.2013.11.007
PG 9
WC Biochemistry & Molecular Biology; Biophysics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics
GA AD8GQ
UT WOS:000333504900019
PM 24246956
DA 2025-06-11
ER

PT J
AU Harada, H
   Warabi, E
   Matsuki, T
   Yanagawa, T
   Okada, K
   Uwayama, J
   Ikeda, A
   Nakaso, K
   Kirii, K
   Noguchi, N
   Bukawa, H
   Siow, RCM
   Mann, GE
   Shoda, J
   Ishii, T
   Sakurai, T
AF Harada, Harumi
   Warabi, Eiji
   Matsuki, Taizo
   Yanagawa, Toru
   Okada, Kosuke
   Uwayama, Junya
   Ikeda, Akira
   Nakaso, Kazuhiro
   Kirii, Kyoko
   Noguchi, Noriko
   Bukawa, Hiroki
   Siow, Richard C. M.
   Mann, Giovanni E.
   Shoda, Junichi
   Ishii, Tetsuro
   Sakurai, Takeshi
TI Deficiency of p62/Sequestosome 1 Causes Hyperphagia Due to Leptin
   Resistance in the Brain
SO JOURNAL OF NEUROSCIENCE
LA English
DT Article
ID PHOSPHOTYROSINE-INDEPENDENT LIGAND; STAT TRANSCRIPTION FACTORS;
   GTPASE-ACTIVATING PROTEIN; RECEPTOR TRAFFICKING; OXIDATIVE STRESS;
   FOOD-INTAKE; MEDIATED ENDOCYTOSIS; ARCUATE NUCLEUS; POMC NEURONS; SH2
   DOMAIN
AB The cytoplasmic regulatory protein p62 (Sequestosome 1/A170) is known to modulate various receptor-mediated intracellular signaling pathways. p62 deficiency was shown to result in mature-onset obesity in mice, but the mechanisms underlying this abnormality remained unclear. Here we report that hyperphagia due to central leptin resistance is the cause of obesity in p62(-/-) mice. We found that these mice show hyperphagia. Restriction of food to the amount eaten by wild-type mice prevented excess body weight gain and fat accumulation, suggesting that overfeeding is the primary cause of obesity in p62(-/-) mice. Brain-specific p62 deficiency caused mature-onset obesity to the same extent as in p62(-/-) mice, further supporting a neuronal mechanism as the major cause of obesity in these mice. Immunohistochemical analysis revealed that p62 is highly expressed in hypothalamic neurons, including POMC neurons in the arcuate nucleus. Central leptin resistance was observed even in young preobese p62(-/-) mice. We found a defect in intracellular distribution of the transcription factor Stat3, which is essential for the action of leptin, in p62(-/-) mice. These results indicate that brain p62 plays an important role in bodyweight control by modulating the central leptin-signaling pathway and that lack of p62 in the brain causes leptin resistance, leading to hyperphagia. Thus, p62 could be a clinical target for treating obesity and metabolic syndrome.
C1 [Harada, Harumi; Warabi, Eiji; Yanagawa, Toru; Okada, Kosuke; Uwayama, Junya; Ikeda, Akira; Kirii, Kyoko; Bukawa, Hiroki; Shoda, Junichi; Ishii, Tetsuro] Univ Tsukuba, Tsukuba, Ibaraki 3058575, Japan.
   [Matsuki, Taizo; Sakurai, Takeshi] Kanazawa Univ, Fac Med, Dept Mol Neurosci & Integrat Physiol, Kanazawa, Ishikawa 9208640, Japan.
   [Matsuki, Taizo] Univ Tsukuba, Ctr Behav Mol Genet, Tsukuba, Ibaraki 3058575, Japan.
   [Nakaso, Kazuhiro] Tottori Univ, Fac Med, Inst Neurol Sci, Dept Neurol, Yonago, Tottori 6838504, Japan.
   [Noguchi, Noriko] Doshisha Univ, Fac Life & Med Sci, Kyoto 6100321, Japan.
   [Siow, Richard C. M.; Mann, Giovanni E.] Kings Coll London, Sch Med, British Heart Fdn Ctr Res Excellence, Div Cardiovasc, London SE1 9NH, England.
C3 University of Tsukuba; Kanazawa University; University of Tsukuba;
   Tottori University; Doshisha University; University of London; King's
   College London
RP Warabi, E (corresponding author), Univ Tsukuba, Tsukuba, Ibaraki 3058575, Japan.
EM warabi-e@md.tsukuba.ac.jp; tsakurai@med.kanazawa-u.ac.jp
RI Sakurai, Takeshi/C-3335-2015; Yanagawa, Toru/GYU-6448-2022
OI Harada, Harumi/0000-0001-7429-7896; Yanagawa, Toru/0000-0003-0868-2563;
   Matsuki, Taizo/0000-0002-0591-4261; Mann, Giovanni/0000-0001-7311-2044
FU Uehara Memorial Foundation; Japan Science and Technology Agency; Cabinet
   Office, Government of Japan through its Funding Program for
   World-Leading Innovative R&D in Science and Technology (FIRST Program);
   Japan Ministry of Education, Culture, Sports, Science, and Technology
   (MEXT) [21659459, 21500386]; Japan Society for the Promotion of Science
   (JSPS) [24790232, 21526]; Grants-in-Aid for Scientific Research
   [21500386, 24790232, 21659459] Funding Source: KAKEN
FX This study was supported by grants from the Uehara Memorial Foundation
   (to E.W.), the Japan Science and Technology Agency (to T.Y.), the
   Cabinet Office, Government of Japan through its Funding Program for
   World-Leading Innovative R&D in Science and Technology (FIRST Program;
   to T.M.), and The Japan Ministry of Education, Culture, Sports, Science,
   and Technology (MEXT; to T.Y., 21659459 and T.I., 21500386), Japan
   Society for the Promotion of Science (JSPS; to E.W., 24790232 and H.H.,
   21526). We thank Professor Jeffrey M. Friedman for providing POMC-EGFP
   and NPY-EGFP transgenic mice. We thank Drs Akihiro Yamanaka, Michihiro
   Mieda, Rika Sugimoto, and Satoshi Sakai for valuable discussions and
   continuous support throughout this study. We also thank Ms Keiko Yamatsu
   and Ms. Miki Kiuchi for technical assistance.
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NR 58
TC 57
Z9 61
U1 1
U2 7
PU SOC NEUROSCIENCE
PI WASHINGTON
PA 11 DUPONT CIRCLE, NW, STE 500, WASHINGTON, DC 20036 USA
SN 0270-6474
J9 J NEUROSCI
JI J. Neurosci.
PD SEP 11
PY 2013
VL 33
IS 37
BP 14767
EP 14777
DI 10.1523/JNEUROSCI.2954-12.2013
PG 11
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 216WG
UT WOS:000324316200015
PM 24027277
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Harte, AL
   da Silva, NF
   Miller, MA
   Cappuccio, FP
   Kelly, A
   O'Hare, JP
   Barnett, AH
   Al-Daghri, NM
   Al-Attas, O
   Alokail, M
   Sabico, S
   Tripathi, G
   Bellary, S
   Kumar, S
   McTernan, PG
AF Harte, Alison L.
   da Silva, Nancy F.
   Miller, Michelle A.
   Cappuccio, Francesco P.
   Kelly, Ann
   O'Hare, Joseph P.
   Barnett, Anthony H.
   Al-Daghri, Nasser M.
   Al-Attas, Omar
   Alokail, Majed
   Sabico, Shaun
   Tripathi, Gyanendra
   Bellary, Srikanth
   Kumar, Sudhesh
   McTernan, Philip G.
TI Telomere Length Attrition, a Marker of Biological Senescence, Is
   Inversely Correlated with Triglycerides and Cholesterol in South Asian
   Males with Type 2 Diabetes Mellitus
SO EXPERIMENTAL DIABETES RESEARCH
LA English
DT Article
ID CARDIOVASCULAR RISK; INSULIN-RESISTANCE; ETHNIC-DIFFERENCES; METABOLIC
   SYNDROME; STRESS; ASSOCIATION; OBESITY; CANCER; CARE
AB South Asians have a higher risk of type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD) than white Caucasians, for a given BMI. Premature biological ageing, assessed by reduction in telomere length (TL), may be mediated by factors resulting from altered metabolic profiles associated with obesity. We hypothesise that ethnicity and metabolic status represent detrimental factors contributing to premature biological ageing. Therefore we assessed TL in two South Asian, age and BMI-matched cohorts [T2DM (n = 142) versus non-T2DM (n = 76)] to determine the effects of BMI, gender, lipid and CVD profile on biological ageing. Genomic DNA was obtained from the UKADS cohort; biochemical and anthropometric data was collected and TL was measured by quantitative real-time PCR. Our findings indicated a gender-specific effect with reduced TL in T2DM men compared with non-T2DM men (P = 0.006). Additionally, in T2DM men, TL was inversely correlated with triglycerides and total cholesterol (r = -0.419, P < 0.01; r = -0.443, P < 0.01). In summary, TL was reduced amongst South Asian T2DM men and correlated with triglycerides and total cholesterol. This study highlights enhanced biological ageing among South Asian, T2DM men, which appears to be tracked by changes in lipids and BMI, suggesting that raised lipids and BMI may directly contribute to premature ageing.
C1 [Harte, Alison L.; da Silva, Nancy F.; Miller, Michelle A.; Cappuccio, Francesco P.; O'Hare, Joseph P.; Tripathi, Gyanendra; Kumar, Sudhesh; McTernan, Philip G.] Univ Warwick, Univ Hosp Coventry & Warwickshire, Warwick Med Sch, Clin Sci Res Labs,Div Metab & Vasc Hlth, Coventry CV2 2DX, W Midlands, England.
   [da Silva, Nancy F.] AstraZeneca R&D, CVGI Biosci, Macclesfield SK10 4TG, Cheshire, England.
   [Kelly, Ann; Barnett, Anthony H.; Bellary, Srikanth] Univ Birmingham, Birmingham B4 7ET, W Midlands, England.
   [Kelly, Ann; Barnett, Anthony H.; Bellary, Srikanth] Heart England NHS Fdn Trust, Biomed Res Ctr, Birmingham B4 7ET, W Midlands, England.
   [Al-Daghri, Nasser M.; Al-Attas, Omar; Alokail, Majed; Sabico, Shaun] King Saud Univ, Coll Sci, Dept Biochem, Biomarkers Res Program, Riyadh 11451, Saudi Arabia.
   [Al-Daghri, Nasser M.; Al-Attas, Omar; Alokail, Majed] King Saud Univ, Ctr Excellence Biotechnol, Riyadh 11451, Saudi Arabia.
   [Bellary, Srikanth] Aston Univ, Birmingham B4 7ET, W Midlands, England.
C3 University of Warwick; AstraZeneca; University of Birmingham; Heart of
   England NHS Foundation Trust; King Saud University; King Saud
   University; Aston University
RP McTernan, PG (corresponding author), Univ Warwick, Univ Hosp Coventry & Warwickshire, Warwick Med Sch, Clin Sci Res Labs,Div Metab & Vasc Hlth, Coventry CV2 2DX, W Midlands, England.
EM p.g.mcternan@warwick.ac.uk
RI Tripathi, Gyanendra/C-8832-2011; Miller, Michelle/D-1840-2009; Barnett,
   Anthony/MCX-8060-2025; Al-Daghri, Nasser/A-8360-2011; Bellary,
   Srikanth/ABA-1977-2020; Al-okail, Majed/E-5565-2016; Cappuccio,
   Francesco/D-3028-2009; kumar, sudhesh/D-6945-2013; Sabico,
   Shaun/C-9086-2011
OI kumar, sudhesh/0000-0003-4326-5941; McTernan,
   Philip/0000-0001-9023-0261; Sabico, Shaun/0000-0002-5248-2350; Miller,
   Michelle/0000-0002-6696-0923; Cappuccio, Francesco
   Paolo/0000-0002-7842-5493; Tripathi, Gyanendra/0000-0001-6889-706X;
   BELLARY, SRIKANTH/0000-0002-5924-5278; Al-Daghri,
   Nasser/0000-0001-5472-1725
FU Birmingham Science City; College of Science Research Center in King Saud
   University; King Abdul Aziz City for Science and Technology (KACST) in
   Riyadh, Saudi Arabia
FX The authors are grateful to UK Asian Diabetes study and WHSS study
   groups. The authors would also like to thank Birmingham Science City for
   their support as well as the Warwickshire Institute for the study of
   Diabetes and Endocrinology. They also thank the College of Science
   Research Center in King Saud University as well as King Abdul Aziz City
   for Science and Technology (KACST) in Riyadh, Saudi Arabia, for their
   support.
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NR 42
TC 58
Z9 67
U1 0
U2 11
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1687-5214
EI 1687-5303
J9 EXP DIABETES RES
JI Exp. Diabetes Res.
PY 2012
AR 895185
DI 10.1155/2012/895185
PG 7
WC Endocrinology & Metabolism; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Research & Experimental Medicine
GA 924GG
UT WOS:000302679200001
PM 22474429
OA hybrid, Green Published, Green Accepted
DA 2025-06-11
ER

PT J
AU Fulghesu, AM
   Sanna, F
   Uda, S
   Magnini, R
   Portoghese, E
   Batetta, B
AF Fulghesu, Anna M.
   Sanna, Francesca
   Uda, Sabrina
   Magnini, Roberta
   Portoghese, Elaine
   Batetta, Barbara
TI Il-6 Serum Levels and Production Is Related to an Altered Immune
   Response in Polycystic Ovary Syndrome Girls with Insulin Resistance
SO MEDIATORS OF INFLAMMATION
LA English
DT Article
ID LOW-GRADE INFLAMMATION; BLOOD MONONUCLEAR-CELLS; C-REACTIVE PROTEIN;
   METABOLIC SYNDROME; CARDIOVASCULAR RISK; CAROTID ATHEROSCLEROSIS;
   ADIPONECTIN LEVELS; OXIDATIVE STRESS; ADIPOSE-TISSUE; YOUNG-PATIENTS
AB Polycystic ovarian syndrome (PCOS) is frequently characterized by obesity and metabolic diseases including hypertension, insulin resistance, and diabetes in adulthood, all leading to an increased risk of atherosclerosis. The present study aimed to evaluate serum and production of inflammatory markers in adolescent Sardinian PCOS. On the basis of HOMA findings, patients were divided into noninsulin resistant (NIR) and insulin resistant (IR), and were weight-and age-matched with healthy girls. Inflammatory cytokines (TNF-alpha, IL-6, Il-10, TGF-beta) and lipokines (leptin, adiponectin), the reactant hs-CRP, and in vitro inflammatory lymphomonocyte response to microbial stimulus were evaluated. In healthy and PCOS subjects, leptin and hs-CRP were correlated with BMI, whereas adiponectin was significantly reduced in all PCOS groups. Although cytokines were similar in all groups, Interleukin-6 (IL-6) was significantly higher in IR PCOS. Moreover, in the latter group lipopolysaccharide-activated monocytes secreted significantly higher levels of IL-6 compared to NIR and control subjects. To conclude, IR PCOS displayed increased IL-6 serum levels and higher secretion in LPS-activated monocytes, whilst revealing no differences for other inflammatory cytokines. These results suggest that in PCOS patients an altered immune response to inflammatory stimuli is present in IR, likely contributing towards determining onset of a low grade inflammation.
C1 [Sanna, Francesca; Uda, Sabrina; Batetta, Barbara] Univ Cagliari, Dipartimento Sci & Tecnol Biomed, I-09124 Cagliari, Italy.
   [Fulghesu, Anna M.; Magnini, Roberta; Portoghese, Elaine] Univ Cagliari, Dipartimento Chirurg Materno Infantile & Sci Imma, I-09124 Cagliari, Italy.
C3 University of Cagliari; Consiglio Nazionale delle Ricerche (CNR);
   Istituto di Tecnologie Biomediche (ITB-CNR); University of Cagliari
RP Batetta, B (corresponding author), Univ Cagliari, Dipartimento Sci & Tecnol Biomed, Via Porcell 4, I-09124 Cagliari, Italy.
EM bbatetta@unica.it
RI Fulghesu, Anna Maria/J-9848-2016
OI Fulghesu, Anna Maria/0000-0001-8116-3968; Batetta,
   Barbara/0000-0001-6932-778X
FU Fondazione Banco di Sardegna, Regione Autonoma della Sardegna;
   Nutrisearch Srl (Italy)
FX The Authors thank Ms. Anne Farmer for editing of the English language,
   Dr. Maria Collu for critical review of the paper, Professor Giacomo Diaz
   for statistical calculations, and Mrs. Anna Saba for technical
   assistance. The study was funded by Fondazione Banco di Sardegna,
   Regione Autonoma della Sardegna and Nutrisearch Srl (Italy).
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NR 54
TC 48
Z9 55
U1 0
U2 16
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 0962-9351
EI 1466-1861
J9 MEDIAT INFLAMM
JI Mediat. Inflamm.
PY 2011
VL 2011
AR 389317
DI 10.1155/2011/389317
PG 8
WC Cell Biology; Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Immunology
GA 760SR
UT WOS:000290344600001
PM 21547256
OA gold, Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Drager, LF
   Jun, JC
   Polotsky, VY
AF Drager, Luciano F.
   Jun, Jonathan C.
   Polotsky, Vsevolod Y.
TI Metabolic consequences of intermittent hypoxia: Relevance to obstructive
   sleep apnea
SO BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Article
DE intermittent hypoxia, obstructive sleep apnea; metabolic syndrome;
   insulin resistance; dyslipidemia
ID POSITIVE AIRWAY PRESSURE; INSULIN-RESISTANCE; LIPOPROTEIN-LIPASE;
   RISK-FACTORS; EPISODIC HYPOXIA; OXIDATIVE STRESS; C57BL/6J MOUSE;
   OBESE-PATIENTS; LEPTIN LEVELS; SERUM LEPTIN
AB Obstructive sleep apnea (OSA) is recurrent obstruction of the upper airway leading to sleep fragmentation and intermittent hypoxia (IH) during sleep. There is growing evidence from animal models of OSA that IH is independently associated with metabolic dysfunction, including dyslipidemia and insulin resistance. The precise mechanisms by which IH induces metabolic disturbances are not fully understood. Over the last decade, several groups of investigators developed a rodent model of IH, which emulates the oxyhemoglobin profile in human USA. In the mouse model, IH induces dyslipidemia, insulin resistance and pancreatic endocrine dysfunction, similar to those observed in human USA. Recent reports provided new insights in possible mechanisms by which IH affects lipid and glucose metabolism. IH may induce dyslipidemia by up-regulating lipid biosynthesis in the liver, increasing adipose tissue lipolysis with subsequent free fatty acid flux to the liver, and inhibiting lipoprotein clearance. IH may affect glucose metabolism by inducing sympathetic activation, increasing systemic inflammation, increasing counter-regulatory hormones and fatty acids, and causing direct pancreatic beta-cell injury. IH models of USA have improved our understanding of the metabolic impact of USA, but further studies are needed before we can translate recent basic research findings to clinical practice. (C) 2010 Elsevier Ltd. All rights reserved.
C1 [Drager, Luciano F.; Jun, Jonathan C.; Polotsky, Vsevolod Y.] Johns Hopkins Univ, Sch Med, Johns Hopkins Asthma & Allergy Ctr, Div Pulm & Crit Care Med, Baltimore, MD 21224 USA.
   [Drager, Luciano F.] Univ Sao Paulo, Fac Med, Hypertens Unit, Cardiol Div,Heart Inst InCor, BR-05508 Sao Paulo, Brazil.
C3 Johns Hopkins University; Johns Hopkins Medicine; Universidade de Sao
   Paulo
RP Polotsky, VY (corresponding author), Johns Hopkins Univ, Sch Med, Johns Hopkins Asthma & Allergy Ctr, Div Pulm & Crit Care Med, 5501 Hopkins Bayview Circle, Baltimore, MD 21224 USA.
EM vpolots1@jhmi.edu
RI Drager, Luciano/A-1535-2014; Stefanadis, Christodoulos/ABH-2232-2020
OI Stefanadis, Christodoulos/0000-0001-5974-6454; Drager,
   Luciano/0000-0002-2081-6846
FU Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
   [200032/2009-7]; Fundacao Zerbini, Brazil; National Sleep
   Foundation/American Lung Association [SF-78568N]; NIH [HL07534, R01
   HL80105, 5P50HL084945]; United States Israel Binational Science
   Foundation [2005265]
FX Luciano F. Drager and Jonathan Jun are Post-Doctoral Fellow at Johns
   Hopkins University. Dr. Drager is supported by the Conselho Nacional de
   Desenvolvimento Cientifico e Tecnologico (CNPq # 200032/2009-7) and
   Fundacao Zerbini, Brazil. Dr.Jun is supported by the National Sleep
   Foundation/American Lung Association Pickwick Grant (SF-78568N) and NIH
   T32 training grant (HL07534).Vsevolod Y. Polotsky is supported by NIH
   (R01 HL80105, 5P50HL084945) and the United States Israel Binational
   Science Foundation (grant BSF No. 2005265).
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NR 84
TC 167
Z9 186
U1 1
U2 8
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1521-690X
EI 1532-1908
J9 BEST PRACT RES CL EN
JI Best Pract. Res. Clin. Endoc. Metab.
PD OCT
PY 2010
VL 24
IS 5
BP 843
EP 851
DI 10.1016/j.beem.2010.08.011
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 701JG
UT WOS:000285813600013
PM 21112030
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Li, YX
   Guo, WW
   Li, H
   Wang, YH
   Liu, XW
   Kong, W
AF Li, Yixuan
   Guo, Wenwen
   Li, Han
   Wang, Yuhao
   Liu, Xinwei
   Kong, Wen
TI The Change of Skeletal Muscle Caused by Inflammation in Obesity as the
   Key Path to Fibrosis: Thoughts on Mechanisms and Intervention Strategies
SO BIOMOLECULES
LA English
DT Review
DE obesity; skeletal muscle; inflammation; fibrosis; insulin resistance
ID FAT AREA RATIO; INSULIN-RESISTANCE; ADIPOSE-TISSUE; SARCOPENIC OBESITY;
   METABOLIC SYNDROME; SATELLITE CELLS; LIVER FIBROSIS; PROGENITORS;
   ACTIVATION; EXPRESSION
AB Obesity leads to a chronic inflammatory state throughout the body, with increased infiltration of immune cells and inflammatory factors in skeletal muscle tissue, and, at the same time, the level of intracellular mitochondrial oxidative stress rises. Meanwhile, obesity is closely related to the development of skeletal muscle fibrosis and can affect the metabolic function of skeletal muscle, triggering metabolic disorders such as insulin resistance (IR) and type 2 diabetes (T2D). However, whether there is a mutual regulatory effect between the two pathological states of inflammation and fibrosis in obese skeletal muscle and the specific molecular mechanisms have not been fully clarified. This review focuses on the pathological changes of skeletal muscle inflammation and fibrosis induced by obesity, covering the metabolic changes it causes, such as lipid deposition, mitochondrial dysfunction, and dysregulation of inflammatory factors, aiming to reveal the intricate connections between the two. In terms of intervention strategies, aerobic exercise, dietary modification, and pharmacotherapy can improve skeletal muscle inflammation and fibrosis. This article provides insight into the important roles of inflammation and fibrosis in the treatment of obesity and the management of skeletal muscle diseases, aiming to provide new ideas for the diagnosis and treatment of metabolic diseases such as obesity and IR.
C1 [Li, Yixuan; Guo, Wenwen; Li, Han; Wang, Yuhao; Liu, Xinwei; Kong, Wen] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Endocrinol, Wuhan 430022, Peoples R China.
   [Li, Yixuan; Guo, Wenwen; Li, Han; Wang, Yuhao; Liu, Xinwei; Kong, Wen] Diabet & Metab Dis Clin Res Ctr Hubei Prov, Wuhan 430022, Peoples R China.
   [Li, Yixuan; Guo, Wenwen; Li, Han; Wang, Yuhao; Liu, Xinwei; Kong, Wen] Huazhong Univ Sci & Technol, Hubei Key Lab Metab Abnormal & Vasc Aging, Wuhan 430022, Peoples R China.
   [Li, Yixuan; Guo, Wenwen; Li, Han; Wang, Yuhao; Liu, Xinwei; Kong, Wen] Natl Ctr Clin Med Res Metab Dis, Hubei Branch, Wuhan 430022, Peoples R China.
C3 Huazhong University of Science & Technology; Huazhong University of
   Science & Technology
RP Kong, W (corresponding author), Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Endocrinol, Wuhan 430022, Peoples R China.; Kong, W (corresponding author), Diabet & Metab Dis Clin Res Ctr Hubei Prov, Wuhan 430022, Peoples R China.; Kong, W (corresponding author), Huazhong Univ Sci & Technol, Hubei Key Lab Metab Abnormal & Vasc Aging, Wuhan 430022, Peoples R China.; Kong, W (corresponding author), Natl Ctr Clin Med Res Metab Dis, Hubei Branch, Wuhan 430022, Peoples R China.
EM 2012xh0841@hust.edu.cn
RI Guo, Wenwen/KIJ-1449-2024; liu, xinwei/IWD-6849-2023; Wang,
   Yuhao/KVY-1757-2024
FU National Natural Science Foundation of China; Bethune-Merck Diabetes
   Research Foundation [G-X-2019-056];  [81974107]
FX This work was supported by the National Natural Science Foundation of
   China (Grant No. 81974107) and the Bethune-Merck Diabetes Research
   Foundation (grant number G-X-2019-056).
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NR 83
TC 0
Z9 0
U1 1
U2 1
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2218-273X
J9 BIOMOLECULES
JI Biomolecules
PD JAN
PY 2025
VL 15
IS 1
AR 20
DI 10.3390/biom15010020
PG 16
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA T4F6Y
UT WOS:001404589700001
PM 39858415
OA gold
DA 2025-06-11
ER

PT J
AU Musazadeh, V
   Morovatshoar, R
   Kavyani, Z
   Vajdi, M
   Askari, G
AF Musazadeh, Vali
   Morovatshoar, Reza
   Kavyani, Zeynab
   Vajdi, Mahdi
   Askari, Gholamreza
TI Effects of flaxseed supplementation on inflammatory biomarkers: A
   GRADE-assessed systematic review and meta-analysis of randomized
   controlled trials
SO PROSTAGLANDINS & OTHER LIPID MEDIATORS
LA English
DT Review
DE Flaxseed; Inflammation; Cytokines; Systematic review; Meta-analysis
ID ALPHA-LINOLENIC-ACID; C-REACTIVE PROTEIN; OIL OMEGA-3-FATTY-ACIDS
   SUPPLEMENTATION; POLYUNSATURATED FATTY-ACIDS; DOUBLE-BLIND; LIPID
   PROFILE; METABOLIC SYNDROME; OXIDATIVE STRESS; CARDIOVASCULAR-DISEASE;
   HEMODIALYSIS-PATIENTS
AB Several studies reported the benefits of flaxseed on inflammatory biomarkers, while others reported conflicting findings. Thus, the aim of this meta alpha nalysis was to assess the impacts of flaxseed on inflammatory biomarkers in adults. Databases including Embase, PubMed, Scopus, and Web of Sciences were searched till February 2024. The 54 RCTs were included in the final analysis, which involved 3000 individuals from 12 countries. Overall, the flaxseed supplementation had a significant reduction in C-reactive protein (CRP) (SMD =-0.46; 95 a/o CI:-0.70,-0.23, P < 0.001; I-2 = 82.9 a/o, P < 0.001), and interleukin 6 (IL-6) (SMD =-0.64, 95 a/o CI:-1.13,-0.16, P = 0.010; I-2 = 92.7, P < 0.001). Furthermore, flaxseed did not significantly change the concentration of tumor necrosis factor alpha (TNF- alpha) (SMD =-0.17; 95 a/o CI:-0.63, 0.29, P = 0.467; I-2 = 92, P < 0.001). Flaxseed supplementation significantly decreased serum concentrations of CRP and IL-6, but not TNF alpha. Thus, this meta-analysis suggests that the current evidence supports the potential benefits of flaxseed in managing inflammatory conditions.
C1 [Musazadeh, Vali] Iran Univ Med Sci, Student Res Comm, Sch Publ Hlth, Tehran, Iran.
   [Musazadeh, Vali] Iran Univ Med Sci, Sch Publ Hlth, Dept Nutr, Tehran, Iran.
   [Morovatshoar, Reza] Hormozgan Univ Med Sci, Hormozgan Hlth Inst, Mol Med Res Ctr, Bandar Abbas, Iran.
   [Kavyani, Zeynab] Shahid Beheshti Univ Med Sci, Natl Nutr & Food Technol Res Inst, Fac Nutr Sci & Food Technol, Dept Clin Nutr & Dietet,Student Res Comm, Tehran, Iran.
   [Vajdi, Mahdi] Isfahan Univ Med Sci, Student Res Comm, Sch Nutr & Food Sci, Dept Community Nutr, Esfahan, Iran.
   [Askari, Gholamreza] Isfahan Univ Med Sci, Nutr & Food Secur Res Ctr, Sch Nutr & Food Sci, Dept Community Nutr, Esfahan, Iran.
C3 Iran University of Medical Sciences; Iran University of Medical
   Sciences; Shahid Beheshti University Medical Sciences; Isfahan
   University of Medical Sciences; Isfahan University of Medical Sciences
RP Vajdi, M (corresponding author), Isfahan Univ Med Sci, Student Res Comm, Sch Nutr & Food Sci, Dept Community Nutr, Esfahan, Iran.; Askari, G (corresponding author), Isfahan Univ Med Sci, Nutr & Food Secur Res Ctr, Sch Nutr & Food Sci, Dept Community Nutr, Esfahan, Iran.
EM MV.vajdi@gmail.com; Askari@mui.ac.ir
RI Morovatshoar, Reza/KLE-0238-2024; Vajdi, Mahdi/GZG-7674-2022
OI Morovatshoar, Reza/0000-0002-0247-7924
FU Isfahan University of Medical Sciences [140216]
FX We would like to extend our heartfelt appreciation to the Student
   Research Committee of Isfahan University of Medical Sciences for their
   generous financial support (Grant number:140216).
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NR 101
TC 2
Z9 2
U1 3
U2 5
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1098-8823
EI 2212-196X
J9 PROSTAG OTH LIPID M
JI Prostaglandins Other Lipid Mediat.
PD OCT
PY 2024
VL 174
AR 106868
DI 10.1016/j.prostaglandins.2024.106868
EA JUL 2024
PG 15
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA ZC0E5
UT WOS:001272966200001
PM 38971216
DA 2025-06-11
ER

PT J
AU Garner, KK
   Hoy, KDS
   Carpenter, AM
AF Garner, Kathryn K.
   Hoy, Kattie D. S.
   Carpenter, Adriana M.
TI Psoriasis: Recognition and Management Strategies
SO AMERICAN FAMILY PHYSICIAN
LA English
DT Article
ID CALCIPOTRIOL SCALP SOLUTION; AMERICAN ACADEMY; NAIL PSORIASIS;
   RISK-FACTORS; ARTHRITIS; EFFICACY; SAFETY; CARE; PATHOPHYSIOLOGY;
   EPIDEMIOLOGY
AB Psoriasis is an inflammatory skin and systemic disorder that affects 3.2% of the U.S. population, including 1% of children. It is an immune-mediated process triggered by an interplay of genetic, environmental, physical (e.g., skin trauma), and infectious factors. Associated comorbidities include cardiovascular disease, obesity, metabolic syndrome, diabetes mellitus, and inflammatory bowel disease. Psoriasis presents in various forms, including plaque, guttate, erythrodermic, pustular, inverse, nail, and psoriatic arthritis. The most common form is plaque psoriasis, which affects 90% of adults with psoriasis. Psoriasis is diagnosed clinically based on the presence of characteristic erythematous, scaly skin plaques in typical locations, with associated history and systemic symptoms. Treatment strategies are similar for most forms of psoriasis and based on body surface area involved. Topical corticosteroids, vitamin D analogues, and tazarotene are used to treat mild to moderate disease. Systemic treatment with nonbiologic and biologic agents and ultraviolet B phototherapy are used for moderate to severe disease, with the exception of apremilast, a systemic agent approved for mild psoriasis. Disease management is improved with maintaining ideal body weight, avoiding tobacco products, limiting alcohol, and practicing stress reduction techniques. The Psoriasis Area and Severity Index is a tool to assess severity and monitor treatment effectiveness over time. Special consideration is needed for treatment of children and patients who are pregnant, breastfeeding, or trying to conceive. Copyright (c) 2023 American Academy of Family Physicians.
C1 [Garner, Kathryn K.; Hoy, Kattie D. S.; Carpenter, Adriana M.] Mike OCallaghan Mil Med Ctr, Family Med Residency Program, Nellis AFB, NV USA.
   Uniformed Serv Univ Hlth Sci, Bethesda, MD USA.
   [Garner, Kathryn K.; Hoy, Kattie D. S.; Carpenter, Adriana M.] Uniformed Serv Univ Hlth Sci, Dept Family Med, Bethesda, MD USA.
C3 United States Department of Defense; United States Air Force; Uniformed
   Services University of the Health Sciences - USA; Uniformed Services
   University of the Health Sciences - USA
RP Garner, KK (corresponding author), 4700 N Las Vegas Blvd, Nellis AFB, NV 89191 USA.
EM Kathryn.k.garner2.mil@health.mil
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NR 66
TC 7
Z9 8
U1 0
U2 3
PU AMER ACAD FAMILY PHYSICIANS
PI KANSAS CITY
PA 8880 WARD PARKWAY, KANSAS CITY, MO 64114-2797 USA
SN 0002-838X
EI 1532-0650
J9 AM FAM PHYSICIAN
JI Am. Fam. Physician
PD DEC
PY 2023
VL 108
IS 6
BP 562
EP 573
PG 12
WC Primary Health Care; Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA ND9E8
UT WOS:001198625200005
PM 38215417
DA 2025-06-11
ER

PT J
AU Liu, SN
   Li, L
   Wang, HR
   Tan, JY
   Wei, L
   Weng, YJ
   Chen, JY
AF Liu, Sainan
   Li, Li
   Wang, Huanran
   Tan, Jianying
   Wei, Lai
   Weng, Yajun
   Chen, Junying
TI Recent Advances: From Cell Biology to Cell Therapy in Atherosclerosis
   Plaque via Stent Implantation
SO CURRENT MEDICINAL CHEMISTRY
LA English
DT Review
DE Atherosclerosis; endothelial cell; smooth muscle cell; macrophage; foam
   cell; stent
ID SMOOTH-MUSCLE-CELLS; ENDOTHELIAL-MESENCHYMAL TRANSITION; REVERSE
   CHOLESTEROL TRANSPORT; ACUTE MYOCARDIAL-INFARCTION; DRUG-ELUTING STENT;
   NITRIC-OXIDE; SURFACE MODIFICATION; METABOLIC SYNDROME; OXIDATIVE
   STRESS; IN-VITRO
AB Atherosclerosis is a multifactorial result of complicated pathophysiology. Changes in the expression of polygenes, coupled with environmental and lifestyle factors, trigger a cascade of adverse events involving a variety of cell types, such as vascular endothelial cells, smooth muscle cells, and macrophages. In this review, we summarize the function and therapeutic targets of atherosclerotic cells. This article reviews the role of endothelial cells, smooth muscle cells, macrophages and foam cells in the development of atherosclerosis and the progress in the treatment of atherosclerosis by targeting these cells. Atherosclerotic plaque involves a variety of cells and biomolecules, and its complex biological environment is a difficult point for the study and treatment of atherosclerosis. For treating atherosclerosis, a large number of studies emerged based on blocking or inhibiting factors affecting the formation and development of plaque. Cardiovascular stent intervention is currently the main method for the treatment of atherosclerosis. In recent decades, numerous studies on cardiovascular, stents mainly involve drug coating or biomolecular modification of stents to enhance anti-thrombosis, anti-restenosis and endothelialization. This paper introduces the research status of cardiovascular stents and new strategies for surface modification. The treatment of atherosclerosis based on the level of molecular biology and cell biology is becoming a research hotspot in the coming decades.
C1 [Liu, Sainan; Li, Li; Wang, Huanran; Tan, Jianying; Wei, Lai; Weng, Yajun; Chen, Junying] Southwest Jiaotong Univ, Sch Mat Sci & Engn, Key Lab Adv Technol Mat Chinese Educ Minist, Chengdu, Peoples R China.
C3 Southwest Jiaotong University
RP Chen, JY (corresponding author), Southwest Jiaotong Univ, Sch Mat Sci & Engn, Key Lab Adv Technol Mat Chinese Educ Minist, Chengdu, Peoples R China.
EM chenjy@263.net
RI Wang, Huanran/AAX-1907-2021
FU National Natural Science Foundation of China [31870955]; National Key
   Research and Development of China [SQ2020YFC1107303]
FX ACKNOWLEDGEMENTS The author would like to acknowledge the National
   Natural Science Foundation of China, Grant/Award Number: 31870955#;
   National Key Research and Development of China, Grant/Award Number:
   SQ2020YFC1107303.
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NR 197
TC 4
Z9 4
U1 4
U2 23
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 0929-8673
EI 1875-533X
J9 CURR MED CHEM
JI Curr. Med. Chem.
PY 2023
VL 30
IS 31
BP 3582
EP 3613
DI 10.2174/0929867330666221028144416
PG 32
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Pharmacology &
   Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
GA J6GH2
UT WOS:001010573300006
PM 36306453
DA 2025-06-11
ER

PT J
AU Lockridge, A
   Hanover, JA
AF Lockridge, Amber
   Hanover, John A.
TI A nexus of lipid and O-Glcnac metabolism in physiology and
   disease
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Review
DE O-GlcNAc; glycosylation; hexosamine biosynthetic pathway; lipid; fatty
   acid; metabolism; obesity; homeostasis
ID ACTIVATED PROTEIN-KINASE; HIGH-FAT DIET; LINKED N-ACETYLGLUCOSAMINE;
   HEXOSAMINE BIOSYNTHETIC-PATHWAY; LIVER-X-RECEPTOR; CIRCULATING LEPTIN
   CONCENTRATIONS; GLUCOSE-INDUCED DESENSITIZATION; LIPOPROTEIN-LIPASE
   ACTIVITY; ADIPOSE-TISSUE; INSULIN-RESISTANCE
AB Although traditionally considered a glucose metabolism-associated modification, the O-linked beta-N-Acetylglucosamine (O-GlcNAc) regulatory system interacts extensively with lipids and is required to maintain lipid homeostasis. The enzymes of O-GlcNAc cycling have molecular properties consistent with those expected of broad-spectrum environmental sensors. By direct protein-protein interactions and catalytic modification, O-GlcNAc cycling enzymes may provide both acute and long-term adaptation to stress and other environmental stimuli such as nutrient availability. Depending on the cell type, hyperlipidemia potentiates or depresses O-GlcNAc levels, sometimes biphasically, through a diversity of unique mechanisms that target UDP-GlcNAc synthesis and the availability, activity and substrate selectivity of the glycosylation enzymes, O-GlcNAc Transferase (OGT) and O-GlcNAcase (OGA). At the same time, OGT activity in multiple tissues has been implicated in the homeostatic regulation of systemic lipid uptake, storage and release. Hyperlipidemic patterns of O-GlcNAcylation in these cells are consistent with both transient physiological adaptation and feedback uninhibited obesogenic and metabolic dysregulation. In this review, we summarize the numerous interconnections between lipid and O-GlcNAc metabolism. These links provide insights into how the O-GlcNAc regulatory system may contribute to lipid-associated diseases including obesity and metabolic syndrome.
C1 [Lockridge, Amber; Hanover, John A.] NIDDK, Lab Cell & Mol Biol, NIH, Bethesda, MD 20892 USA.
C3 National Institutes of Health (NIH) - USA; NIH National Institute of
   Diabetes & Digestive & Kidney Diseases (NIDDK)
RP Lockridge, A; Hanover, JA (corresponding author), NIDDK, Lab Cell & Mol Biol, NIH, Bethesda, MD 20892 USA.
EM amber.lockridge@nih.gov; jah@helix.nih.gov
FU NIDDK intramural research program [ZIADK060103]
FX Funding was provided by NIDDK intramural research program grant
   ZIADK060103.
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NR 349
TC 13
Z9 15
U1 1
U2 8
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD AUG 30
PY 2022
VL 13
AR 943576
DI 10.3389/fendo.2022.943576
PG 35
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 8Z1QC
UT WOS:000933160700001
PM 36111295
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Barre, T
   Fontaine, H
   Pol, S
   Ramier, C
   Di Beo, V
   Protopopescu, C
   Marcellin, F
   Bureau, M
   Bourliere, M
   Dorival, C
   Petrov-Sanchez, V
   Asselah, T
   Delarocque-Astagneau, E
   Larrey, D
   Duclos-Vallee, JC
   Carrat, F
   Carrieri, P
AF Barre, Tangui
   Fontaine, Helene
   Pol, Stanislas
   Ramier, Clemence
   Di Beo, Vincent
   Protopopescu, Camelia
   Marcellin, Fabienne
   Bureau, Morgane
   Bourliere, Marc
   Dorival, Celine
   Petrov-Sanchez, Ventzislava
   Asselah, Tarik
   Delarocque-Astagneau, Elisabeth
   Larrey, Dominique
   Duclos-Vallee, Jean-Charles
   Carrat, Fabrice
   Carrieri, Patrizia
CA ANRS AFEF Hepather Study Grp
TI Metabolic Disorders in Patients with Chronic Hepatitis B Virus
   Infection: Coffee as a Panacea? (ANRS CO22 Hepather Cohort)
SO ANTIOXIDANTS
LA English
DT Article
DE coffee; tea; hepatitis B; metabolic syndrome; dyslipidemia;
   hypertension; polyphenol
ID DOSE-RESPONSE METAANALYSIS; CIGARETTE-SMOKING; HEPATOCELLULAR-CARCINOMA;
   ANTIOXIDANT CAPACITY; DIABETES-MELLITUS; OXIDATIVE STRESS; TEA
   CONSUMPTION; BLOOD-PRESSURE; RISK-FACTORS; HYPERTENSION
AB People living with chronic hepatitis B virus (HBV) infection are at high risk of liver disease progression, which is positively associated with metabolic disorders, but inversely associated with dyslipidemia. Diet, including dietary antioxidants, is a lever of metabolic disorder management. In particular, elevated coffee consumption is associated with different metabolic outcomes in the general population. We aimed to test whether such associations occur in HBV-infected people. Based on cross-sectional data from the ANRS CO22 Hepather cohort, we performed logistic regression models with (i) dyslipidemia, (ii) hypertension, and (iii) diabetes as outcomes, and with demographic, clinical, and socio-behavioral (including coffee consumption) data as explanatory variables. Among 4746 HBV-infected patients, drinking >= 3 cups of coffee per day was associated with a higher risk of dyslipidemia (adjusted odds ratio [95% confidence interval] 1.49 [1.10-2.00], p = 0.009) and a lower risk of hypertension (0.64 [0.50-0.82], p = 0.001). It was not associated with diabetes. Elevated coffee consumption was associated with a higher risk of dyslipidemia and a lower risk of hypertension in HBV-infected patients, two effects expected to be associated with favorable clinical outcomes. Further studies should test whether such metabolic benefits translate into reduced mortality risk in this population.
C1 [Barre, Tangui; Ramier, Clemence; Di Beo, Vincent; Protopopescu, Camelia; Marcellin, Fabienne; Bureau, Morgane; Bourliere, Marc; Carrieri, Patrizia] Aix Marseille Univ, INSERM, Sci Econ & Sociales Sante & Traitement Informat M, IRD,SESSTIM,ISSPAM, F-13005 Marseille, France.
   [Fontaine, Helene; Pol, Stanislas] Univ Paris, Hop Cochin, AP HP, Dept Hepatol Addictol, F-75014 Paris, France.
   [Bourliere, Marc] Hop St Joseph, Serv Hepatogastroenterol, F-13008 Marseille, France.
   [Dorival, Celine] Sorbonne Univ, Inst Pierre Louis Epidemiol & Sante Publ, INSERM, F-75646 Paris, France.
   [Petrov-Sanchez, Ventzislava] Unit Basic & Clin Res Viral Hepatitis, ANRS MIE France Rech Nord & Sud Sida HIV Hepatite, F-73013 Paris, France.
   [Asselah, Tarik] Univ Paris, INSERM, Ctr Rech Inflammat, UMR1149, F-75018 Paris, France.
   [Asselah, Tarik] Hop Beaujon, AP HP, Dept Hepatol, F-92110 Clichy, France.
   [Delarocque-Astagneau, Elisabeth] Univ Paris Saclay, UVSQ, INSERM, CESP,Team Antiinfect Evas & Pharmacoepidemiol, F-78180 Montigny, France.
   [Delarocque-Astagneau, Elisabeth] GHU Paris Saclay Univ, Raymond Poincare Hosp, AP HP, Epidemiol & Publ Hlth Dept, F-92380 Garches, France.
   [Larrey, Dominique] Hop St Eloi, INSERM, IRB, Liver Unit, F-34090 Montpellier, France.
   [Duclos-Vallee, Jean-Charles] Univ Paris Saclay, Hop Paul Brousse, AP HP, Ctr Hepatobiliaire,FHU HEPATINOV,UMR S 1193, F-94800 Villejuif, France.
   [Carrat, Fabrice] Hop St Antoine, AP HP, Unite Sante Publ, F-75012 Paris, France.
C3 Institut National de la Sante et de la Recherche Medicale (Inserm);
   Institut de Recherche pour le Developpement (IRD); Aix-Marseille
   Universite; Assistance Publique Hopitaux Paris (APHP); Universite Paris
   Cite; Hopital Universitaire Cochin - APHP; Sorbonne Universite; Institut
   National de la Sante et de la Recherche Medicale (Inserm); Institut
   National de la Sante et de la Recherche Medicale (Inserm); Universite
   Paris Cite; Universite Paris Cite; Assistance Publique Hopitaux Paris
   (APHP); Hopital Universitaire Beaujon - APHP; Universite Paris Saclay;
   Institut National de la Sante et de la Recherche Medicale (Inserm);
   Assistance Publique Hopitaux Paris (APHP); Hopital Universitaire
   Raymond-Poincare - APHP; Universite de Montpellier; CHU de Montpellier;
   Institut National de la Sante et de la Recherche Medicale (Inserm);
   Assistance Publique Hopitaux Paris (APHP); Hopital Universitaire
   Paul-Brousse - APHP; Institut National de la Sante et de la Recherche
   Medicale (Inserm); Universite Paris Saclay; Assistance Publique Hopitaux
   Paris (APHP); Sorbonne Universite; Hopital Universitaire Saint-Antoine -
   APHP
RP Carrieri, P (corresponding author), Aix Marseille Univ, INSERM, Sci Econ & Sociales Sante & Traitement Informat M, IRD,SESSTIM,ISSPAM, F-13005 Marseille, France.
EM tangui.barre@inserm.fr; helene.fontaine@aphp.fr; stanislas.pol@aphp.fr;
   clemence.ramier@inserm.fr; vincent.di-beo@inserm.fr;
   camelia.protopopescu@inserm.fr; fabienne.marcellin@inserm.fr;
   morgane-diane.bureau@inserm.fr; mbourliere@hopital-saint-joseph.fr;
   celine.dorival@iplesp.upmc.fr; ventzislava.petrov-sanchez@anrs.fr;
   tarik.asselah@aphp.fr; elisabeth.delarocque-astagneau@uvsq.fr;
   dom-larrey@chu-montpellier.fr; jean-charles.duclos-vallee@aphp.fr;
   fabrice.carrat@iplesp.upmc.fr; maria-patrizia.carrieri@inserm.fr
RI Carrieri, Maria Patrizia/LZG-7375-2025; Protopopescu,
   Camelia/JXL-8202-2024; Carrat, Fabrice/AAU-8480-2020; Marcellin,
   Fabienne/H-7911-2019; Barré, Tangui/CAH-2871-2022; Carrat,
   Fabrice/P-6177-2017; delarocque-astagneau, elisabeth/E-4706-2016
OI Carrieri, Patrizia/0000-0002-6794-4837; DI BEO,
   Vincent/0000-0002-6252-8316; Ramier, Clemence/0000-0002-1928-0263;
   Carrat, Fabrice/0000-0002-8672-7918; Marcellin,
   Fabienne/0000-0001-8853-3829; Barre, Tangui/0000-0002-3439-8868;
   Protopopescu, Camelia/0000-0003-0164-7917; delarocque-astagneau,
   elisabeth/0000-0002-5129-9300
FU INSERM-ANRS MIE (France REcherche Nord&sud Sida-vih Hepatites|Maladies
   Infectieuses Emergentes); ANR Equipex and Cohort (Agence Nationale de la
   Recherche); DGS (Direction Generale de la Sante); MSD; Janssen; Gilead;
   Abbvie; BMS; Roche
FX The Hepather cohort is funded by INSERM-ANRS MIE (France REcherche
   Nord&sud Sida-vih Hepatites|Maladies Infectieuses Emergentes), ANR
   Equipex and Cohort (Agence Nationale de la Recherche), DGS (Direction
   Generale de la Sante) and MSD, Janssen, Gilead, Abbvie, BMS, Roche.
   These funding sources had no role in the writing of the manuscript, or
   in the decision to submit it for publication.
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NR 100
TC 5
Z9 5
U1 1
U2 9
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD FEB
PY 2022
VL 11
IS 2
AR 379
DI 10.3390/antiox11020379
PG 20
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA ZL6LJ
UT WOS:000763786400001
PM 35204261
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Nieman, KM
   Anderson, BD
   Cifelli, CJ
AF Nieman, Kristin M.
   Anderson, Barbara D.
   Cifelli, Christopher J.
TI The Effects of Dairy Product and Dairy Protein Intake on Inflammation: A
   Systematic Review of the Literature
SO JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION
LA English
DT Review
DE Dairy; inflammation; chronic disease; diet; systematic review
ID HEALTH CURRENT RESEARCH; LOW-GRADE INFLAMMATION; DISEASE RISK-FACTORS;
   C-REACTIVE PROTEIN; CARDIOVASCULAR-DISEASE; ENDOTHELIAL FUNCTION;
   METABOLIC SYNDROME; FOOD-CONSUMPTION; OXIDATIVE STRESS; DIETARY PATTERN
AB Systemic inflammation is associated with obesity and chronic disease risk. Intake of dairy foods is associated with reduced risk of type 2 diabetes and cardiovascular disease; however, the impact of dairy foods on inflammation is not well-established. The objective of this study was to conduct a systematic review to evaluate the effect of dairy product (milk, cheese, and yogurt) and dairy protein consumption on low-grade systemic inflammation in adults without severe inflammatory disorders. A literature search was completed in September 2019 using PubMed and CENTRAL as well as inspection of reference lists from relevant review articles. The search resulted in the identification of 27 randomized controlled trials which were included in this analysis. In the 19 trials which evaluated dairy products, 10 reported no effect of the intervention, while 8 reported a reduction in at least one biomarker of inflammation. All 8 trials that investigated dairy protein intake on markers of inflammation reported no effect of the intervention. The available literature suggests that dairy products and dairy proteins have neutral to beneficial effects on biomarkers of inflammation. Additional clinical studies designed using inflammatory biomarkers as the primary outcome are needed to fully elucidate the effects of dairy intake on inflammation.
C1 [Nieman, Kristin M.] Katalyses, 513 SW Camden Dr, Ankeny, IA 50023 USA.
   [Cifelli, Christopher J.] Natl Dairy Council, Rosemont, IL USA.
RP Nieman, KM (corresponding author), Katalyses, 513 SW Camden Dr, Ankeny, IA 50023 USA.
EM knieman@katalyses.com
RI Nieman, Kristin/KEE-6319-2024
OI Nieman, Kristin/0000-0001-7529-0872
FU National Dairy Council, Rosemont, IL [2941]
FX This study was funded by a grant [#2941] awarded to Katalyses from
   National Dairy Council, Rosemont, IL. Employees of the funding
   organization participated in the study design and manuscript
   preparation.
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NR 105
TC 53
Z9 54
U1 3
U2 25
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 0731-5724
EI 1541-1087
J9 J AM COLL NUTR
JI J. Am. Coll. Nutr.
PD AUG 6
PY 2021
VL 40
IS 6
BP 571
EP 582
DI 10.1080/07315724.2020.1800532
EA AUG 2020
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA UC8QY
UT WOS:000564995600001
PM 32870744
OA hybrid
DA 2025-06-11
ER

PT J
AU Tian, M
   Reichetzeder, C
   Li, J
   Hocher, B
AF Tian, Mei
   Reichetzeder, Christoph
   Li, Jian
   Hocher, Berthold
TI Low birth weight, a risk factor for diseases in later life, is a
   surrogate of insulin resistance at birth
SO JOURNAL OF HYPERTENSION
LA English
DT Review
DE epigenetics; fetal programing; genetics; insulin resistance; low birth
   weight
ID INTRAUTERINE GROWTH-RETARDATION; FOR-GESTATIONAL-AGE;
   ENDOPLASMIC-RETICULUM STRESS; CHRONIC KIDNEY-DISEASE; YOUNG-ADULTS BORN;
   BETA-CELL FAILURE; HIGH-FAT-DIET; DEVELOPMENTAL ORIGINS; METABOLIC
   SYNDROME; IN-UTERO
AB Low birth weight (LBW) is associated with diseases in adulthood. The birthweight attributed risk is independent of confounding such as gestational age, sex of the newborn but also social factors. The birthweight attributed risk for diseases in later life holds for the whole spectrum of birthweight. This raises the question what pathophysiological principle is actually behind the association. In this review, we provide evidence that LBW is a surrogate of insulin resistance. Insulin resistance has been identified as a key factor leading to type 2 diabetes, cardiovascular disease as well as kidney diseases. We first provide evidence linking LBW to insulin resistance during intrauterine life. This might be caused by both genetic (genetic variations of genes controlling glucose homeostasis) and/or environmental factors (due to alterations of macronutrition and micronutrition of the mother during pregnancy, but also effects of paternal nutrition prior to conception) leading via epigenetic modifications to early life insulin resistance and alterations of intrauterine growth, as insulin is a growth factor in early life. LBW is rather a surrogate of insulin resistance in early life - either due to inborn genetic or environmental reasons - rather than a player on its own.
C1 [Tian, Mei; Li, Jian; Hocher, Berthold] Hunan Normal Univ, Sch Med, Key Lab Study & Discovery Small Targeted Mol Huna, Changsha, Peoples R China.
   [Reichetzeder, Christoph] Univ Potsdam, Inst Nutr Sci, Nuthetal, Germany.
   [Hocher, Berthold] Heidelberg Univ, Univ Med Ctr Mannheim, Dept Med Nephrol Endocrinol Rheumatol 5, Heidelberg, Germany.
   [Hocher, Berthold] Reprod & Genet Hosp CITIC Xiangya, Changsha, Peoples R China.
C3 Hunan Normal University; University of Potsdam; Ruprecht Karls
   University Heidelberg; Central South University
RP Hocher, B (corresponding author), Hunan Normal Univ, Sch Med, Key Lab Study & Discovery Small Targeted Mol Huna, Changsha, Peoples R China.; Hocher, B (corresponding author), Heidelberg Univ, Univ Med Ctr Mannheim, Dept Med Nephrol Endocrinol Rheumatol 5, Heidelberg, Germany.
EM berthold.hocher@medma.uni-heidelberg.de
RI Hocher, Berthold/AAC-3510-2020
FU National Natural Science Foundation of China [81873861]; Hunan Province
   Natural Science Foundation [2018JJ3366]
FX This project was supported by National Natural Science Foundation of
   China (Grant No. 81873861) and Hunan Province Natural Science Foundation
   (Grant No. 2018JJ3366.
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NR 166
TC 24
Z9 24
U1 2
U2 20
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0263-6352
EI 1473-5598
J9 J HYPERTENS
JI J. Hypertens.
PD NOV
PY 2019
VL 37
IS 11
BP 2123
EP 2134
DI 10.1097/HJH.0000000000002156
PG 12
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA KF8HP
UT WOS:000509478200003
PM 31157747
DA 2025-06-11
ER

PT J
AU Calvano, A
   Izuora, K
   Oh, EC
   Ebersole, JL
   Lyons, TJ
   Basu, A
AF Calvano, Aaron
   Izuora, Kenneth
   Oh, Edwin C.
   Ebersole, Jeffrey L.
   Lyons, Timothy J.
   Basu, Arpita
TI Dietary berries, insulin resistance and type 2 diabetes: an overview of
   human feeding trials
SO FOOD & FUNCTION
LA English
DT Review
ID C-REACTIVE PROTEIN; CRANBERRY JUICE; OXIDATIVE STRESS; ANTIOXIDANT
   CAPACITY; GUT MICROBIOTA; DOUBLE-BLIND; POSTPRANDIAL GLUCOSE; METABOLIC
   PARAMETERS; BLUEBERRY JUICE; UNITED-STATES
AB Dietary berries are a rich source of several nutrients and phytochemicals and in recent years, accumulating evidence suggests they can reduce risks of several chronic diseases, including type 2 diabetes (T2D). The objective of this review is to summarize and discuss the role of dietary berries (taken as fresh, frozen, or other processed forms) on insulin resistance and biomarkers of T2D in human feeding studies. Reported feeding trials involve different berries taken in different forms, and consequently differences in nutritional or polyphenol composition must be considered in their interpretation. Commonly consumed berries, especially cranberries, blueberries, raspberries and strawberries, ameliorate postprandial hyperglycemia and hyperinsulinemia in overweight or obese adults with insulin resistance, and in adults with the metabolic syndrome (MetS). In non-acute long-term studies, these berries either alone, or in combination with other functional foods or dietary interventions, can improve glycemic and lipid profiles, blood pressure and surrogate markers of atherosclerosis. Studies specifically in people with T2D are few, and more knowledge is needed. Nevertheless, existing evidence, although sparse, suggests that berries have an emerging role in dietary strategies for the prevention of diabetes and its complications in adults. Despite the beneficial effects of berries on diabetes prevention and management, they must be consumed as part of a healthy and balanced diet.
C1 [Calvano, Aaron; Basu, Arpita] Univ Nevada, Dept Kinesiol & Nutr Sci, Las Vegas, NV 89154 USA.
   [Izuora, Kenneth] Univ Nevada, Dept Internal Med, Sect Endocrinol, Las Vegas, NV 89154 USA.
   [Oh, Edwin C.] Univ Nevada, Nevada Inst Personalized Med, Las Vegas, NV 89154 USA.
   [Ebersole, Jeffrey L.] Univ Nevada, Sch Dent Med, Las Vegas, NV 89154 USA.
   [Lyons, Timothy J.] Med Univ South Carolina, Div Endocrinol, Charleston, SC 29425 USA.
C3 Nevada System of Higher Education (NSHE); University of Nevada Las
   Vegas; Nevada System of Higher Education (NSHE); University of Nevada
   Las Vegas; Nevada System of Higher Education (NSHE); University of
   Nevada Las Vegas; Nevada System of Higher Education (NSHE); University
   of Nevada Las Vegas; Medical University of South Carolina
RP Basu, A (corresponding author), Univ Nevada, Dept Kinesiol & Nutr Sci, Las Vegas, NV 89154 USA.
EM Arpita.basu@unlv.edu
OI Izuora, Kenneth/0000-0001-7171-3073; Calvano, Aaron/0000-0001-6256-8206;
   Lyons, Timothy/0000-0003-2106-1622
FU California Strawberry Commission; Cranberry Institute; US Highbush
   Blueberry Council
FX The corresponding author Dr Arpita Basu has received partial funding
   from the California Strawberry Commission, the Cranberry Institute and
   the US Highbush Blueberry Council to support research reported in this
   review.
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NR 101
TC 59
Z9 63
U1 4
U2 70
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PD OCT 1
PY 2019
VL 10
IS 10
BP 6227
EP 6243
DI 10.1039/c9fo01426h
PG 17
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA JE9BP
UT WOS:000490983800001
PM 31591634
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Xu, LX
   Li, T
   Yin, JH
   Lin, G
   Xu, YL
   Ren, Y
   Wang, Y
   Yang, J
   Chen, LM
AF Xu, Linxin
   Li, Ting
   Yin, Jianhong
   Lin, Gang
   Xu, Yali
   Ren, Yi
   Wang, Yan
   Yang, Jing
   Chen, Liming
TI Association between serum uric acid and nonalcoholic fatty liver disease
   in community patients with type 2 diabetes mellitus
SO PEERJ
LA English
DT Article
DE Type 2 diabetes mellitus; Serum uric acid; Nonalcoholic fatty liver
   disease; Male sex
ID METABOLIC SYNDROME; RISK-FACTOR; HYPERURICEMIA; PREVALENCE; LEVEL;
   POPULATION; GENERATION; CRITERIA; STRESS; HEALTH
AB Background. To investigate whether SUA is associated with NAFLD in men and women with T2DM.
   Methods. This cross-sectional study enrolled patients with T2DM at Shanxi High-Tech Development Zone Central Hospital (June 2011 to September 2017). Patients were stratified according to gender and presence/absence of NAFLD. Parameters associated with NAFLD were identified using multivariate stepwise linear regression and univariate/multivariate logistic regression.
   Results. Among 597 patients (325 males) enrolled, 352 had NAFLD. SUA was higher in the NAFLD group than in the non-NAFLD group for both men and women (P < 0.001). Multiple linear regression showed that body mass index (positively), triglycerides (positively) and estimated glomerular filtration rate (negatively) were independently related to SUA (P < 0.001). Univariate logistic regression revealed increased odds of NAFLD for SUA tertiles 2 (P = 0.022) and 3 (P = 0.001) in women and tertile 3 (P = 0.039) in men. After adjustment for multiple clinical parameters, SUA tertiles were significantly associated with NAFLD for tertile 3 in women (P = 0.014), although there were trends toward associations for tertile 2 in women (P = 0.074) and tertiles 2 and 3 in men (P = 0.085 and 0.054, respectively).
   Conclusion. SUA is not independently associated with NAFLD in men or women with T2DM after rigorous adjustment for other metabolic parameters.
C1 [Xu, Linxin; Li, Ting; Chen, Liming] Tianjin Med Univ, Metab Dis Hosp, Tianjin Key Lab Metab Dis, NHC Key Lab Hormones & Dev, Tianjin, Peoples R China.
   [Xu, Linxin; Li, Ting; Chen, Liming] Tianjin Med Univ, Inst Endocrinol, Tianjin, Peoples R China.
   [Xu, Linxin; Yin, Jianhong; Ren, Yi; Wang, Yan; Yang, Jing] Shanxi Med Univ, Hosp 1, Dept Endocrinol, Taiyuan, Shanxi, Peoples R China.
   [Lin, Gang; Xu, Yali] Changzhi High Tech Dev Zone Cent Hosp, Dept Endocrinol, Changzhi, Shanxi, Peoples R China.
C3 Tianjin Medical University; Tianjin Medical University; Shanxi Medical
   University
RP Chen, LM (corresponding author), Tianjin Med Univ, Metab Dis Hosp, Tianjin Key Lab Metab Dis, NHC Key Lab Hormones & Dev, Tianjin, Peoples R China.; Chen, LM (corresponding author), Tianjin Med Univ, Inst Endocrinol, Tianjin, Peoples R China.; Yang, J (corresponding author), Shanxi Med Univ, Hosp 1, Dept Endocrinol, Taiyuan, Shanxi, Peoples R China.
EM yangjlim@126.com; xfx22081@yip.163.com
RI xu, yali/GWC-9971-2022
FU National Natural Science Foundation of China [81470187, 81270882];
   Natural Science Foundation of Tianjin [15ZXHLSY00460, 18JCYBJC26100];
   Shanxi Provincial Health and Family Planning Commission [2017043]
FX This work was supported by the National Natural Science Foundation of
   China (Grant No. 81470187), (Grant NO.81270882) the Natural Science
   Foundation of Tianjin (Grant Nos. 15ZXHLSY00460 and 18JCYBJC26100), and
   the Shanxi Provincial Health and Family Planning Commission research
   project (Grant No. 2017043). The funders had no role in study design,
   data collection and analysis, decision to publish, or preparation of the
   manuscript.
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NR 51
TC 9
Z9 9
U1 0
U2 12
PU PEERJ INC
PI LONDON
PA 341-345 OLD ST, THIRD FLR, LONDON, EC1V 9LL, ENGLAND
SN 2167-8359
J9 PEERJ
JI PeerJ
PD AUG 26
PY 2019
VL 7
AR e7563
DI 10.7717/peerj.7563
PG 18
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA IT2XC
UT WOS:000482716000008
PM 31523513
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Yang, SJ
   Liu, YX
   Qiao, YH
   Wu, GZ
   Cai, WQ
AF Yang, Shijie
   Liu, Yixian
   Qiao, Yuhai
   Wu, Guozhu
   Cai, Wenqing
TI Protective effect of resveratrol against prostate enlargement induced by
   high-fat diet
SO INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY
LA English
DT Article
DE Benign prostatic hyperplasia; resveratrol; pioglitazone; insulin
   resistance; PPAR gamma; COX-2; NOX-2; rat
ID URINARY-TRACT SYMPTOMS; METABOLIC SYNDROME; OXIDATIVE STRESS;
   INSULIN-RESISTANCE; PPAR-GAMMA; RISK-FACTORS; HYPERPLASIA; INFLAMMATION;
   CANCER; CYCLOOXYGENASE-2
AB Background: Resveratrol has shown preventing effect on prostate diseases. This research was performed to investigate the protective effect of resveratrol on prostate enlargement induced by high-fat diet (HFD). Methods: Rats were divided into four groups: normal pellet diet feeding (NPD), high-fat diet feeding (HFD), resveratrol treating (HFD+RES) and pioglitazone treating (HFD+PIO) groups. Fasting insulin and glucose level were assessed by radioimmunoassay and capillary blood glucose method respectively. Insulin resistance was evaluated by Homeostasis Model Assessment of insulin resistance index (HOMA-IR). Body weight, prostate weigh, and visceral fat weight in were measured and prostate index was calculated. The expression of PPAR gamma, COX-2, NOX-2, SOD-1 and SOD-2 were revealed by using western blot analysis. Results: Insulin level in HFD group was increased than in NPD group. Resveratrol administration decreased the level of insulin and induced a decline trend in HOMA-IR. Resveratrol had similar effect with pioglitazone in decreasing prostate weight, visceral fat and PI. Furthermore, they reversed the up-regulated expression of COX-2 and NOX-2, as well as the down-regulated expression of PPAR gamma, SOD-1 and SOD-2 produced by HFD-fed. Conclusion: Resveratrol has protective effects on improving prostate enlargement induced by HFD which was achieved by alleviating hyperinsulinemia, anti-inflammatory and antioxidative characteristics.
C1 [Yang, Shijie; Qiao, Yuhai; Wu, Guozhu] Third Hosp Hebei Med Univ, Dept Urol, Shijiazhuang, Hebei, Peoples R China.
   [Liu, Yixian] Hebei Med Univ, Dept Physiol, Shijiazhuang, Hebei, Peoples R China.
   [Cai, Wenqing] Second Hosp Hebei Med Univ, Dept Urol, 215 Heping West Rd, Shijiazhuang 050000, Hebei, Peoples R China.
C3 Hebei Medical University
RP Cai, WQ (corresponding author), Second Hosp Hebei Med Univ, Dept Urol, 215 Heping West Rd, Shijiazhuang 050000, Hebei, Peoples R China.
EM wenqingcai@126.com
FU Hebei province natural science foundation of China [C2014206363]
FX This work was supported by Hebei province natural science foundation of
   China (C2014206363). Professor Sheng Wang provided writing assistance;
   Professor Yi Zhang provided general support.
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NR 46
TC 0
Z9 0
U1 0
U2 4
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 1936-2625
J9 INT J CLIN EXP PATHO
JI Int. J. Clin. Exp. Pathol.
PY 2017
VL 10
IS 2
BP 1529
EP 1538
PG 10
WC Oncology; Pathology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Pathology
GA EN0ZC
UT WOS:000395739000071
DA 2025-06-11
ER

PT J
AU Knutsson, A
   Hsiung, S
   Celik, S
   Rattik, S
   Mattisson, IY
   Wigren, M
   Scher, HI
   Nilsson, J
   Hultgårdh-Nilsson, A
AF Knutsson, Anki
   Hsiung, Sabrina
   Celik, Selvi
   Rattik, Sara
   Mattisson, Ingrid Yao
   Wigren, Maria
   Scher, Howard I.
   Nilsson, Jan
   Hultgardh-Nilsson, Anna
TI Treatment with a GnRH receptor agonist, but not the GnRH receptor
   antagonist degarelix, induces atherosclerotic plaque instability in
   ApoE<SUP>-/-</SUP> mice
SO SCIENTIFIC REPORTS
LA English
DT Article
ID ANDROGEN-SUPPRESSION THERAPY; PROSTATE-CANCER; DEPRIVATION THERAPY;
   CELL-PROLIFERATION; METABOLIC SYNDROME; GENE-EXPRESSION; HORMONE GNRH;
   DISEASE; MEN; MORTALITY
AB Androgen-deprivation therapy (ADT) for prostate cancer has been associated with increased risk for development of cardiovascular events and recent pooled analyses of randomized intervention trials suggest that this primarily is the case for patients with pre-existing cardiovascular disease treated with gonadotropin-releasing hormone receptor (GnRH-R) agonists. In the present study we investigated the effects of the GnRH-R agonist leuprolide and the GnRH-R antagonist degarelix on established atherosclerotic plaques in ApoE(-/-) mice. A shear stress modifier was used to produce both advanced and more stable plaques in the carotid artery. After 4 weeks of ADT, increased areas of necrosis was observed in stable plaques from leuprolide-treated mice (median and IQR plaque necrotic area in control, degarelix and leuprolide-treated mice were 0.6% (IQR 0-3.1), 0.2% (IQR 0-4.4) and 11.0% (IQR 1.0-19.8), respectively). There was also evidence of increased inflammation as assessed by macrophage immunohistochemistry in the plaques from leuprolide-treated mice, but we found no evidence of such changes in plaques from control mice or mice treated with degarelix. Necrosis destabilizes plaques and increases the risk for rupture and development of acute cardiovascular events. Destabilization of pre-existing atherosclerotic plaques could explain the increased cardiovascular risk in prostate cancer patients treated with GnRH-R agonists.
C1 [Knutsson, Anki; Hsiung, Sabrina; Celik, Selvi; Hultgardh-Nilsson, Anna] Lund Univ, Dept Expt Med Sci, Lund, Sweden.
   [Rattik, Sara; Mattisson, Ingrid Yao; Wigren, Maria; Nilsson, Jan] Lund Univ, Dept Clin Sci Malmoe, Malmo, Sweden.
   [Scher, Howard I.] Mem Sloan Kettering Canc Ctr, Sidney Kimmel Ctr Prostate & Urol Canc, 1275 York Ave, New York, NY 10021 USA.
   [Scher, Howard I.] Weill Cornell Med Coll, New York, NY USA.
C3 Lund University; Lund University; Memorial Sloan Kettering Cancer
   Center; Cornell University; Weill Cornell Medicine
RP Knutsson, A (corresponding author), Lund Univ, Dept Expt Med Sci, Lund, Sweden.
EM Anki.Knutsson@med.lu.se
RI Nilsson, Jan/HNP-4869-2023
OI Celik, Selvi/0000-0001-7032-3444; Yao Mattisson,
   Ingrid/0000-0002-5954-5334
FU Swedish Research Council; Swedish Heart and Lung Foundation; MSK Cancer
   Center Support Grant/Core Grant [P30 CA008748]; Ferring Inc.
FX This study was supported by grants from the Swedish Research Council,
   Swedish Heart and Lung Foundation, MSK Cancer Center Support Grant/Core
   Grant (P30 CA008748) and Ferring Inc. The authors are grateful to Hans
   Lilja, Memorial Sloan Kettering Cancer center, New York, for helpful
   discussions.
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NR 28
TC 43
Z9 47
U1 0
U2 1
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD MAY 18
PY 2016
VL 6
AR 26220
DI 10.1038/srep26220
PG 10
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA DL9WV
UT WOS:000375995000001
PM 27189011
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Schultz, A
   Barbosa-da-Silva, S
   Aguila, MB
   Mandarim-De-Lacerda, CA
AF Schultz, Alini
   Barbosa-da-Silva, Sandra
   Aguila, Marcia B.
   Mandarim-de-Lacerda, Carlos A.
TI Differences and similarities in hepatic lipogenesis, gluconeogenesis and
   oxidative imbalance in mice fed diets rich in fructose or sucrose
SO FOOD & FUNCTION
LA English
DT Article
ID FATTY LIVER-DISEASE; NONALCOHOLIC STEATOHEPATITIS NASH;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; ADIPOSE-TISSUE; OBESITY;
   MECHANISMS; PATHOGENESIS; STEATOSIS; STRESS
AB Changes in feeding habits are the primary environmental factors (though modifiable) commonly correlated with increase in diseases such as obesity and associated comorbidities. Diets rich in fructose and sucrose have been related to the epidemic of obesity. Three groups of mice were studied during 15 weeks of consuming standard chow (SC), a high-fructose diet (HFru) and a high-sucrose diet (HSu). The animals did not present significant differences in food intake, energy intake, or body mass evolution at the end of the experiment. Although the findings in the HFru and HSu animals were not equal in magnitude, in comparison with the SC mice, the HFru and HSu animals showed hyperglycemia, hyperinsulinemia and hyper-leptinemia as well as high levels of inflammatory adipokines, low adiponectin, and high levels of total cholesterol, triacylglycerol, and liver enzymes. The liver of HFru (more) and HSu (less) groups showed fatty infiltration and areas of necroinflammation, which are characteristic of the transition from nonalcoholic fatty liver disease to nonalcoholic steatohepatitis. In addition, the HFru and HSu groups showed increased lipogenesis, gluconeogenesis, reduced beta-oxidation and antioxidant imbalance compared with the SC animals. In conclusion, current findings demonstrate comparable adverse effects on carbohydrate metabolism, inflammatory profile, antioxidant imbalance and NAFLD in the mice of the C57BL/6 strain fed a diet rich in sucrose or rich in fructose.
C1 [Schultz, Alini; Barbosa-da-Silva, Sandra; Aguila, Marcia B.; Mandarim-de-Lacerda, Carlos A.] Univ Estado Rio De Janeiro, Inst Biol, Biomed Ctr, Lab Morphometry Metab & Cardiovasc Dis, Rio De Janeiro, RJ, Brazil.
C3 Universidade do Estado do Rio de Janeiro
RP Schultz, A (corresponding author), Univ Estado Rio De Janeiro, Inst Biol, Biomed Ctr, Lab Morphometry Metab & Cardiovasc Dis, Rio De Janeiro, RJ, Brazil.
EM mandarim@uerj.br
RI Barbosa-da-Silva, Sandra/K-3794-2012; Aguila, Marcia/P-2349-2019;
   Mandarim-de-Lacerda, Carlos/P-2360-2019
OI Barbosa da Silva, Sandra/0000-0003-3866-0912; Mandarim-de-Lacerda,
   Carlos/0000-0003-4134-7978; Barbosa Aguila, Marcia/0000-0003-3994-4589
CR Aguila M, 2003, LIVER INT, V23, P363, DOI 10.1034/j.1478-3231.2003.00858.x
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NR 38
TC 33
Z9 36
U1 0
U2 12
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PY 2015
VL 6
IS 5
BP 1684
EP 1691
DI 10.1039/c5fo00251f
PG 8
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA CI1SI
UT WOS:000354524300030
PM 25905791
DA 2025-06-11
ER

PT J
AU Novo, E
   Cannito, S
   Patemostro, C
   Bocca, C
   Miglietta, A
   Parola, M
AF Novo, Erica
   Cannito, Stefania
   Patemostro, Claudia
   Bocca, Claudia
   Miglietta, Antonella
   Parola, Maurizio
TI Cellular and molecular mechanisms in liver fibrogenesis
SO ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
LA English
DT Review
DE Liver fibrogenesis; Hepatic myofibroblasts; Chronic liver injury;
   Fibrogenic mechanisms; Chronic inflammation; Extracellular matrix
ID HEPATIC STELLATE CELLS; EPITHELIAL-MESENCHYMAL TRANSITION; IL-1 RECEPTOR
   ANTAGONIST; TOLL-LIKE RECEPTOR-4; KILLER T-CELLS; NF-KAPPA-B;
   NATURAL-KILLER; NONALCOHOLIC STEATOHEPATITIS; PROANGIOGENIC CYTOKINES;
   INSULIN-RESISTANCE
AB Liver fibrogenesis is a dynamic and highly integrated molecular, tissue and cellular process, potentially reversible, that drives the progression of chronic liver diseases (CLD) towards liver cirrhosis and hepatic failure. Hepatic myofibroblasts (MFs), the pro-fibrogenic effector cells, originate mainly from activation of hepatic stellate cells and portal fibroblasts being characterized by a proliferative and survival attitude. MFs also contract in response to vasoactive agents, sustain angiogenesis and recruit and modulate activity of cells of innate or adaptive immunity. Chronic activation of wound healing and oxidative stress as well as derangement of epithelial mesenchymal interactions are "major" pro-fibrogenic mechanisms, whatever the etiology. However, literature has outlined a complex network of pro-fibrogenic factors and mediators proposed to modulate CLD progression, with some of them being at present highly debated in the field, including the role of epithelial to mesenchymal transition and Hedgehog signaling pathways. Hypoxia and angiogenesis as well as inflammasomes are recently emerged as ubiquitous pro-inflammatory and pro-fibrogenic determinants whereas adipokines are mostly involved in CLD related to metabolic disturbances (metabolic syndrome and/or obesity and type 2 diabetes). Finally, autophagy as well as natural killer and natural killer-T cells have been recently proposed to significantly affect fibrogenic CLD progression. (C) 2014 Elsevier Inc. All rights reserved.
C1 [Novo, Erica; Cannito, Stefania; Patemostro, Claudia; Bocca, Claudia; Miglietta, Antonella; Parola, Maurizio] Univ Turin, Dept Clin & Biol Sci, Unit Expt Med & Clin Pathol, I-10125 Turin, Italy.
C3 University of Turin
RP Parola, M (corresponding author), Univ Turin, Sch Med, Unit Expt Med & Clin Pathol, Dept Clin & Biol Sci, Corso Raffaello 30, I-10125 Turin, Italy.
EM maurizio.parola@unito.it
RI Bocca, Claudia/J-8160-2016; Parola, Maurizio/HJH-2266-2023; cannito,
   stefania/H-5487-2013
OI Cannito, Stefania/0000-0001-9883-6882; Parola,
   Maurizio/0000-0001-7720-5141; novo, erica/0000-0003-2586-4246
FU Italian Ministero dell'Universita e della Ricerca (MIUR, Rome - PRIN
   Project) [2009ARYX4T]; Regione Piemonte (Torino); Fondazione CRT
   (Torino); Fondazione CariPLO (Milan); University of Torino
FX Financial support was from the Italian Ministero dell'Universita e della
   Ricerca (MIUR, Rome - PRIN 2009 Project 2009ARYX4T, to M.P.), the
   Regione Piemonte (Torino, to M.P. and E.N), the Fondazione CRT (Torino,
   to M.P.), the Fondazione CariPLO (Milan, to MP), the University of
   Torino (to EN, CB, AM, MP).
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NR 148
TC 157
Z9 170
U1 0
U2 34
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0003-9861
EI 1096-0384
J9 ARCH BIOCHEM BIOPHYS
JI Arch. Biochem. Biophys.
PD APR 15
PY 2014
VL 548
BP 20
EP 37
DI 10.1016/j.abb.2014.02.015
PG 18
WC Biochemistry & Molecular Biology; Biophysics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics
GA AF8OK
UT WOS:000334975300003
PM 24631571
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Perampaladas, K
   Gori, T
   Parker, JD
AF Perampaladas, Kumar
   Gori, Tommaso
   Parker, John D.
TI Rosiglitazone Causes Endothelial Dysfunction in Humans
SO JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS
LA English
DT Article
DE cardiac pharmacology; nonantiarrhythmic; cardiac pharmacology;
   endothelium; nitrate tolerance
ID TYPE-2 DIABETES-MELLITUS; CORONARY-ARTERY-DISEASE; RECEPTOR-GAMMA
   AGONIST; HUMAN IN-VIVO; NITRATE TOLERANCE; OXIDATIVE STRESS;
   INSULIN-RESISTANCE; NONDIABETIC PATIENTS; METABOLIC SYNDROME; THERAPY
AB Objectives: We explored the impact of rosiglitazone on endothelial function in normal volunteers and its interaction with glyceryl trinitrate (GTN)-induced abnormalities in endothelial function. We hypothesized that rosiglitazone would have a neutral effect on endothelial function in normal volunteers and would favorably modify endothelial dysfunction induced by GTN. Methods: In this double-blind, randomized, placebo-controlled study, 44 participants were randomized to placebo, rosiglitazone (4 mg twice daily), transdermal GTN (0.6 mg/h), or both GTN and rosiglitazone. After 7 days of treatment, participants underwent measures of forearm blood flow during brachial artery infusion of acetylcholine (Ach). Serum glucose concentrations and insulin sensitivity were assessed. Results: Unexpectedly, rosiglitazone-treated participants experienced blunted responses to endothelium-dependent responses to Ach (P < .05 vs placebo). Sustained GTN administration caused similar abnormalities in endothelial function (P < .05 vs placebo) and rosiglitazone + GTN (P < .05 vs placebo; P = ns vs rosiglitazone). Interestingly, co-infusion of the antioxidant vitamin C improved endothelial responses in those randomized to rosiglitazone and GTN alone (P = not significant [ns] compared with placebo), but it did not improve endothelial function in those treated with rosiglitazone + GTN. Neither rosiglitazone nor GTN treatment modified the measures of glucose metabolism. Conclusions: Unexpectedly, therapy with rosiglitazone caused abnormalities in endothelial function in normal volunteers. These findings have important implications with respect to drug development and surveillance.
C1 [Perampaladas, Kumar; Parker, John D.] Univ Toronto, Mt Sinai Hosp, Toronto, ON M5G 1X5, Canada.
   [Perampaladas, Kumar; Parker, John D.] Univ Toronto, Div Cardiol, Dept Med, Univ Hlth Network, Toronto, ON M5G 1X5, Canada.
   [Perampaladas, Kumar; Parker, John D.] Univ Toronto, Dept Pharmacol & Toxicol, Toronto, ON M5G 1X5, Canada.
   [Gori, Tommaso] Johannes Gutenberg Univ Mainz, Dept Cardiol, Mainz, Germany.
C3 University of Toronto; Sinai Health System Toronto; University of
   Toronto; University Health Network Toronto; University of Toronto;
   Johannes Gutenberg University of Mainz
RP Parker, JD (corresponding author), Univ Toronto, Mt Sinai Hosp, 600 Univ Ave,Room 1609, Toronto, ON M5G 1X5, Canada.
EM john.parker@uhn.ca
RI Gori, Tommaso/F-1575-2012
OI Parker, John/0000-0003-1949-2669
FU John H. Daniels Cardiac Research Centre; Mecklinger and Posluns Cardiac
   Catheterization Research Laboratory of the Mount Sinai Hospital,
   Toronto; Heart and Stroke Foundation of Ontario; Heart and Stroke
   Foundation of Ontario, Canada
FX The authors recognize the support provided by the John H. Daniels
   Cardiac Research Centre and the Mecklinger and Posluns Cardiac
   Catheterization Research Laboratory of the Mount Sinai Hospital,
   Toronto.The author(s) disclosed receipt of the following financial
   support for the research, authorship, and/or publication of this
   article: This research was supported by a grant-in-aid of the Heart and
   Stroke Foundation of Ontario. Dr Parker holds a Career Investigator
   Award from the Heart and Stroke Foundation of Ontario, Canada.
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   Administration USFaD, 2011, ROS RISK EV MIT STAT
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NR 37
TC 6
Z9 6
U1 0
U2 4
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1074-2484
J9 J CARDIOVASC PHARM T
JI J. Cardiovasc. Pharmacol. Ther.
PD SEP
PY 2012
VL 17
IS 3
BP 260
EP 265
DI 10.1177/1074248411425490
PG 6
WC Cardiac & Cardiovascular Systems; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Pharmacology & Pharmacy
GA 986IY
UT WOS:000307336500003
PM 22053074
DA 2025-06-11
ER

PT J
AU Kim, G
   Kim, GH
   Oh, GS
   Yoon, J
   Kim, HW
   Kim, MS
   Kim, SW
AF Kim, Gukhan
   Kim, Geun Hyang
   Oh, Gyun-Sik
   Yoon, Jin
   Kim, Hae Won
   Kim, Min-Seon
   Kim, Seung-Whan
TI SREBP-1c regulates glucose-stimulated hepatic clusterin expression
SO BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
LA English
DT Article
DE Clusterin; Apolipoprotein J; Glucose; SREBP-1c; E-box
ID CORONARY-HEART-DISEASE; APOLIPOPROTEIN-J; GENE-EXPRESSION; CANCER;
   OVEREXPRESSION; PROGRESSION; BIOMARKER; ISOFORMS; RECEPTOR; DENSITY
AB Clusterin is a stress-response protein that is involved in diverse biological processes, including cell proliferation, apoptosis, tissue differentiation, inflammation, and lipid transport. Its expression is upregulated in a broad spectrum of diverse pathological states. Clusterin was recently reported to be associated with diabetes, metabolic syndrome, and their sequelae. However, the regulation of clusterin expression by metabolic signals was not addressed. In this study we evaluated the effects of glucose on hepatic clusterin expression. Interestingly, high glucose concentrations significantly increased clusterin expression in primary hepatocytes and hepatoma cell lines, but the conventional promoter region of the clusterin gene did not respond to glucose stimulation. In contrast, the first intronic region was transcriptionally activated by high glucose concentrations. We then defined a glucose response element (GIRE) of the clusterin gene, showing that it consists of two E-box motifs separated by five nucleotides and resembles carbohydrate response element (ChoRE). Unexpectedly, however, these E-box motifs were not activated by ChoRE binding protein (ChREBP), but were activated by sterol regulatory element binding protein-1c (SREBP-1c). Furthermore, we found that glucose induced recruitment of SREBP-1c to the E-box of the clusterin gene intronic region. Taken together, these results suggest that clusterin expression is increased by glucose stimulation, and SREBP-1c plays a crucial role in the metabolic regulation of clusterin. (C) 2011 Elsevier Inc. All rights reserved.
C1 [Kim, Gukhan; Kim, Geun Hyang; Oh, Gyun-Sik; Yoon, Jin; Kim, Hae Won; Kim, Seung-Whan] Univ Ulsan, Dept Pharmacol, Coll Med, Asan Med Ctr, Seoul 138736, South Korea.
   [Kim, Min-Seon] Univ Ulsan, Dept Internal Med, Coll Med, Asan Med Ctr, Seoul 138736, South Korea.
   [Kim, Geun Hyang; Oh, Gyun-Sik; Yoon, Jin; Kim, Seung-Whan] Univ Ulsan, Biomed Inst Technol, Coll Med, Seoul 138736, South Korea.
C3 University of Ulsan; Asan Medical Center; University of Ulsan; Asan
   Medical Center; University of Ulsan
RP Kim, SW (corresponding author), Univ Ulsan, Dept Pharmacol, Coll Med, Asan Med Ctr, 388-1 PungNap,2Dong, Seoul 138736, South Korea.
EM swkim7@amc.seoul.kr
RI KIM, SUNJONG/JXN-0257-2024; KIM, SIWOUK/KCY-8510-2024
OI Kim, Seung-Whan/0000-0001-6983-0481
FU Korean Government [2006-0050225, 2009-0084114]; Ministry for Health,
   Welfare & Family Affairs, Republic of Korea [A084335]; Asan Institute
   for Life Sciences, Seoul, Korea [2007-352, 2009-352]
FX This work was supported by grants from the National Research Foundation
   of Korea funded by the Korean Government (2006-0050225 and
   2009-0084114); the Korea Health Technology R&D Project, Ministry for
   Health, Welfare & Family Affairs, Republic of Korea (A084335); and by
   intramural grants (2007-352 and 2009-352) from the Asan Institute for
   Life Sciences, Seoul, Korea.
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NR 35
TC 20
Z9 23
U1 0
U2 13
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0006-291X
EI 1090-2104
J9 BIOCHEM BIOPH RES CO
JI Biochem. Biophys. Res. Commun.
PD MAY 20
PY 2011
VL 408
IS 4
BP 720
EP 725
DI 10.1016/j.bbrc.2011.04.111
PG 6
WC Biochemistry & Molecular Biology; Biophysics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics
GA 773FU
UT WOS:000291293200038
PM 21549685
DA 2025-06-11
ER

PT J
AU McCurdy, CE
   Bishop, JM
   Williams, SM
   Grayson, BE
   Smith, MS
   Friedman, JE
   Grove, KL
AF McCurdy, Carrie E.
   Bishop, Jacalyn M.
   Williams, Sarah M.
   Grayson, Bernadette E.
   Smith, M. Susan
   Friedman, Jacob E.
   Grove, Kevin L.
TI Maternal high-fat diet triggers lipotoxicity in the fetal livers of
   nonhuman primates
SO JOURNAL OF CLINICAL INVESTIGATION
LA English
DT Article
ID GESTATIONAL DIABETES-MELLITUS; HOMEOSTASIS MODEL ASSESSMENT;
   GENE-EXPRESSION; ADIPOSE-TISSUE; BIRTH-WEIGHT; INSULIN-RESISTANCE;
   BODY-COMPOSITION; NUTRIENT RESTRICTION; METABOLIC SYNDROME;
   GLUCOSE-TOLERANCE
AB Maternal obesity is thought to increase the offspring's risk of juvenile obesity and metabolic diseases; however, the mechanism(s) whereby excess maternal nutrition affects fetal development remain poorly understood. Here, we investigated in nonhuman primates the effect of chronic high-fat diet (HFD) on the development of fetal metabolic systems. We found that fetal offspring from both lean and obese mothers chronically consuming a HFD had a 3-fold increase in liver triglycerides (TGs). In addition, fetal offspring from HFD-fed mothers (O-HFD) showed increased evidence of hepatic oxidative stress early in the third trimester, consistent with the development of nonalcoholic fatty liver disease (NAFLD). O-HFD animals also exhibited elevated hepatic expression of gluconeogenic enzymes and transcription factors. Furthermore, fetal glycerol levels were 2-fold higher in O-HFD animals than in control fetal offspring and correlated with maternal levels. The increased fetal hepatic TG levels persisted at P180, concurrent with a 2-fold increase in percent body fat. Importantly, reversing the maternal HFD to a low-fat diet during a subsequent pregnancy improved fetal hepatic TG levels and partially normalized gluconeogenic enzyme expression, without changing maternal body weight. These results suggest that a developing fetus is highly vulnerable to excess lipids, independent of maternal diabetes and/or obesity, and that exposure to this may increase the risk of pediatric NAFLD.
C1 [Bishop, Jacalyn M.; Williams, Sarah M.; Grayson, Bernadette E.; Smith, M. Susan; Grove, Kevin L.] Oregon Hlth & Sci Univ, ONPRC, Div Neurosci, Beaverton, OR 97007 USA.
   [McCurdy, Carrie E.; Friedman, Jacob E.] Univ Colorado Denver, Dept Pediat, Aurora, CO USA.
C3 Oregon Health & Science University; Oregon National Primate Research
   Center; Children's Hospital Colorado; University of Colorado System;
   University of Colorado Anschutz Medical Campus
RP Grove, KL (corresponding author), Oregon Hlth & Sci Univ, ONPRC, Div Neurosci, 505 NW 185th, Beaverton, OR 97007 USA.
EM jed.friedman@ucdenver.edu; grovek@ohsu.edu
OI Comstock, Sarah/0000-0003-0284-5798; McCurdy, Carrie/0000-0003-1177-9040
FU NIH [DK-60685, DK-79194, RR00163, DKF32-075252, DK-062155]
FX This work was funded by NIH grants DK-60685 (to K.L. Grove), DK-79194
   (to K.L. Grove), RR00163 (to K.L. Grove and ONPRC), DKF32-075252 (to
   C.E. McCurdy), and DK-062155 (to J.E. Friedman). The authors would like
   to acknowledge the technical assistance of Lindsay Pranger, Sandra
   Joachim, Christopher Osman, Diana Takahashi, and the Division of Animal
   Resources and Veterinary staff at ONPRC for their technical assistance
   with these studies. The authors also acknowledge David Hess and the RJA
   Core.
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NR 98
TC 494
Z9 546
U1 0
U2 43
PU AMER SOC CLINICAL INVESTIGATION INC
PI ANN ARBOR
PA 2015 MANCHESTER RD, ANN ARBOR, MI 48104 USA
SN 0021-9738
EI 1558-8238
J9 J CLIN INVEST
JI J. Clin. Invest.
PD FEB
PY 2009
VL 119
IS 2
BP 323
EP 335
DI 10.1172/JCI32661
PG 13
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 403LP
UT WOS:000263084400013
PM 19147984
OA Green Published, Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU de Roos, B
   Duivenvoorden, I
   Rucklidge, G
   Reid, M
   Ross, K
   Lamers, RJAN
   Voshol, PJ
   Havekes, LM
   Teusink, B
AF de Roos, B
   Duivenvoorden, I
   Rucklidge, G
   Reid, M
   Ross, K
   Lamers, RJAN
   Voshol, PJ
   Havekes, LM
   Teusink, B
TI Response of apolipoprotein E*3-Leiden transgenic mice to dietary fatty
   acids: combining liver proteomics with physiological data
SO FASEB JOURNAL
LA English
DT Article
DE fish oil; CLA; elaidic acid; lipoprotein metabolism; glucose metabolism
ID CONJUGATED LINOLEIC-ACID; CHOLESTEROL LEVELS; LIPID-COMPOSITION;
   BODY-COMPOSITION; GENE-EXPRESSION; DOWN-REGULATION; SERUM-LIPIDS;
   ATHEROSCLEROSIS; LIPOPROTEINS; METABOLISM
AB Dietary fatty acids have a profound impact on atherosclerosis, but mechanisms are not fully understood. We studied the effects of a saturated fat diet supplemented with fish oil, trans10,cis12 conjugated linoleic acid (CLA), or elaidic acid on lipid and glucose metabolism and liver protein levels of APOE*3 Leiden transgenic mice, a model for lipid metabolism and atherosclerosis. Fish oil lowered plasma and liver cholesterol and triglycerides, plasma free fatty acids, and glucose but increased plasma insulin. CLA lowered plasma cholesterol but increased plasma and liver triglycerides, plasma beta-hydroxybutyrate, and insulin. Elaidic acid lowered plasma and liver cholesterol. Proteomics identified significant regulation of 65 cytosolic and 8-membrane proteins. Many of these proteins were related to lipid and glucose metabolism, and to oxidative stress. Principal component analysis revealed that fish oil had a major impact on cytosolic proteins, and elaidic acid on membrane proteins. Correlation analysis between physiological and protein data revealed novel clusters of correlated variables, among which a metabolic syndrome cluster. The combination of proteomics and physiology gave new insights in mechanisms by which these dietary fatty acids regulate lipid metabolism and related pathways, for example, by altering protein levels of long-chain acyl-CoA thioester hydrolase and adipophilin in the liver.
C1 Rowett Res Inst, Aberdeen AB21 9SB, Scotland.
   TNO Prevent & Hlth, Gaubius Lab, Leiden, Netherlands.
   TNO Nutr & Food Res, Zeist, Netherlands.
   Leiden Univ, Med Ctr, Dept Endocrinol, Leiden, Netherlands.
   Leiden Univ, Med Ctr, Dept Cardiol, Leiden, Netherlands.
   Leiden Univ, Med Ctr, Dept Internal Med, Leiden, Netherlands.
   Wageningen Ctr Food Sci, NIZO Food Res, Ede, Netherlands.
C3 University of Aberdeen; Netherlands Organization Applied Science
   Research; Netherlands Organization Applied Science Research; Leiden
   University - Excl LUMC; Leiden University; Leiden University Medical
   Center (LUMC); Leiden University - Excl LUMC; Leiden University; Leiden
   University Medical Center (LUMC); Leiden University; Leiden University
   Medical Center (LUMC); Leiden University - Excl LUMC; NIZO Food Research
RP Rowett Res Inst, Greenburn Rd, Aberdeen AB21 9SB, Scotland.
EM b.deroos@rowett.ac.uk
OI de Roos, Baukje/0000-0002-2750-3914; Teusink, Bas/0000-0003-3929-0423
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NR 63
TC 55
Z9 56
U1 0
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0892-6638
EI 1530-6860
J9 FASEB J
JI Faseb J.
PD MAR
PY 2005
VL 19
IS 3
BP 813
EP +
DI 10.1096/fj.04-2974fje
PG 26
WC Biochemistry & Molecular Biology; Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 910AH
UT WOS:000227901300025
PM 15755870
DA 2025-06-11
ER

PT J
AU Gawryjolek, M
   Wicinski, M
   Gawryjolek, MM
   Zabrzynski, J
AF Gawryjolek, Michal
   Wicinski, Michal
   Gawryjolek, Marta Michalska
   Zabrzynski, Jan
TI Vitamin D Supplementation Effects on Markers Related with Endothelial
   Function and Coagulation in Obese Orthopedic Patients: Insights from
   Acute and Chronic Cases
SO NUTRIENTS
LA English
DT Article
DE orthopedic conditions; coagulation; endothelial function; vitamin D;
   obesity
ID PLASMINOGEN-ACTIVATOR INHIBITOR-1; TISSUE FACTOR;
   CARDIOVASCULAR-DISEASE; RISK-FACTORS; VENOUS THROMBOEMBOLISM; METABOLIC
   SYNDROME; OXIDATIVE STRESS; GENE-EXPRESSION; ALL-CAUSE; T-PA
AB Obesity is a risk factor for thrombosis-related diseases and a condition that leads to vitamin D deficiency. Furthermore, orthopedic conditions are also at risk for diseases associated with coagulation and endothelial function. This study aimed to assess whether vitamin D supplementation in patients with acute (AOCs) and chronic orthopedic conditions (COCs) and coexisting obesity could affect coagulation and endothelial function. Thirty-three obese individuals with AOCs or COCs were included in the study. Patients were supplemented with vitamin D at 4000 IU/day for 3 months. An enzyme-linked immunosorbent assay (ELISA) was used to measure the concentrations of alpha 2-antiplasmin (alpha 2AP), vascular cell adhesion molecule 1 (VCAM-1), plasminogen activator inhibitor-1 (PAI-1), tissue factor pathway inhibitor (TFPI), and vitamin D, which were examined at two time points-before and after supplementation. Regardless of the increase in serum vitamin D levels in both groups after supplementation, there was a statistically significant increase in VCAM-1 and PAI-1 levels in the group with AOCs, whereas only VCAM-1 increased statistically significantly in the second group. For obese patients with COCs, vitamin D does not appear to have a potentially beneficial effect on coagulation and the endothelium.
C1 [Gawryjolek, Michal] Dr L Blazek Multispecialty Hosp, Dept Orthopaed & Traumatol, PL-88100 Inowroclaw, Poland.
   [Wicinski, Michal] Nicolaus Copernicus Univ, Fac Med, Dept Pharmacol & Therapeut, Coll Medicum Bydgoszcz, M Curie 9, PL-85090 Bydgoszcz, Poland.
   [Gawryjolek, Marta Michalska] Dr L Blazek Multispecialty Hosp, Dept Radiol, PL-88100 Inowroclaw, Poland.
   [Zabrzynski, Jan] Nicolaus Copernicus Univ Torun, Fac Med, Dept Orthopaed & Traumatol, Coll Medicum Bydgoszcz, PL-85092 Bydgoszcz, Poland.
C3 Nicolaus Copernicus University; Nicolaus Copernicus University
RP Gawryjolek, M (corresponding author), Dr L Blazek Multispecialty Hosp, Dept Orthopaed & Traumatol, PL-88100 Inowroclaw, Poland.
EM gawryjolekm83@gmail.com; michal.wicinski@cm.umk.pl;
   michalskamarta86@gmail.com
RI Zabrzynski, Jan/AAG-3295-2019
OI Zabrzynski, Jan/0000-0003-2714-2466
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NR 64
TC 0
Z9 0
U1 1
U2 1
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD MAR
PY 2025
VL 17
IS 5
AR 882
DI 10.3390/nu17050882
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 0AA6M
UT WOS:001442428900001
PM 40077751
OA gold
DA 2025-06-11
ER

PT J
AU Zhang, C
   Zhang, DM
   Huang, HG
   Lu, XQ
   Shi, HS
   Liu, KX
   Guo, XL
   Zhang, R
   Wang, H
AF Zhang, Cong
   Zhang, Dingmei
   Huang, Hegui
   Lu, Xiaoqian
   Shi, Huasong
   Liu, Kexin
   Guo, Xiaoling
   Zhang, Rui
   Wang, Hui
TI Cathepsin D mediates prenatal caffeine exposure-caused NAFLD
   susceptibility in male rat offspring by regulating autophagy
SO FREE RADICAL BIOLOGY AND MEDICINE
LA English
DT Article
DE Prenatal caffeine exposure; Cathepsin D; Autophagy; NAFLD; Intrauterine
   origin
ID NONALCOHOLIC FATTY LIVER; PITUITARY-ADRENAL AXIS; GROWTH RESTRICTION;
   METABOLIC SYNDROME; LIPID-METABOLISM; DISEASE; INDUCTION; HEALTH;
   GLUCOCORTICOIDS; STEATOSIS
AB Epidemiological evidence has revealed that non-alcoholic fatty liver disease (NAFLD) harbors an intrauterine origin. Autophagy is known to be involved in the protective mechanism in the development of adult NAFLD, but whether it engages in the occurrence of fetal-originated NAFLD remains unclear. In this study, a rat model of fetal-originated NAFLD was established by giving a high-fat diet or chronic stress after birth on prenatal caffeine exposure (PCE) male offspring. The alterations of liver morphologic analysis, lipid metabolism, and autophagy before and after birth were determined to confirm autophagy mechanism, NAFLD susceptibility, and intrauterine origin in PCE male adult offspring. Our results revealed that PCE-induced intrauterine high concentration of corticosterone exposure blocked autophagic flux by inhibiting cathepsin D expression in hepatocytes, leading to beta-oxidation inhibition and lipid accumulation in the liver. Moreover, high concentration of corticosterone upregulated miR-665 by activating the glucocorticoid receptor to suppress cathepsin D, thus causing lysosomal degradation dysfunction and autophagy flux blockade. Notably, hepatic overexpression of cathepsin D could reverse PCE-induced postnatal NAFLD susceptibility in male rat offspring. This study elucidates the epigenetic programming mechanism of intrauterine autophagy-related fetal-originated NAFLD susceptibility, and identifies cathepsin D as its early intervention target, providing an experimental basis for exploring early prevention and treatment strategies for fetal-originated NAFLD.
C1 [Zhang, Cong; Zhang, Dingmei; Lu, Xiaoqian; Shi, Huasong; Liu, Kexin; Guo, Xiaoling; Zhang, Rui; Wang, Hui] Wuhan Univ, Sch Basic Med Sci, Dept Pharmacol, Wuhan 430071, Peoples R China.
   [Huang, Hegui; Wang, Hui] Hubei Prov Key Lab Dev Originated Dis, Wuhan 430071, Peoples R China.
   [Huang, Hegui] Wuhan 1 Hosp, Wuhan 430022, Peoples R China.
C3 Wuhan University
RP Wang, H (corresponding author), Wuhan Univ, Sch Basic Med Sci, Dept Pharmacol, Wuhan 430071, Peoples R China.
EM wanghui19@whu.edu.cn
RI Zhang, Dingmei/ABC-7476-2020; , 张睿/L-4466-2016; Guo,
   Xiaoling/AAJ-2958-2020; Liu, Kexin/MTC-4480-2025
FU National Key Research and Development Program of China [2020YFA0803900];
   National Natural Science Foundation of China [82030111, 81803646,
   81673524]; Major Technological Innovation Projects of Hubei Province
   [2019ACA140, 2020BCA071]; Medical Science Advancement Program (Basic
   Medical Sciences) of Wuhan University [TFJC2018001]; Hubei Province's
   Outstanding Medical Academic Leader program
FX This study was supported by the National Key Research and Development
   Program of China (No. 2020YFA0803900) , the National Natural Science
   Foundation of China (No. 82030111, 81803646, 81673524) , the Major
   Technological Innovation Projects of Hubei Province (No. 2019ACA140,
   2020BCA071) , Hubei Province's Outstanding Medical Academic Leader
   program, and Medical Science Advancement Program (Basic Medical
   Sciences) of Wuhan University (No. TFJC2018001) .
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NR 70
TC 1
Z9 1
U1 1
U2 7
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0891-5849
EI 1873-4596
J9 FREE RADICAL BIO MED
JI Free Radic. Biol. Med.
PD NOV 1
PY 2023
VL 208
BP 684
EP 699
DI 10.1016/j.freeradbiomed.2023.09.026
EA SEP 2023
PG 16
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA U6SB9
UT WOS:001086072200001
PM 37743032
DA 2025-06-11
ER

PT J
AU Ismail, LC
   Osaili, TM
   Mohamad, MN
   Hashim, M
   Stojanovska, L
   Al Daour, R
   Nader, D
   Alrayis, H
   Alzaabi, NS
   Elbarag, L
   Binkhadim, S
   Jarrar, AH
   Al Dhaheri, AS
   Hasan, H
AF Ismail, Leila Cheikh
   Osaili, Tareq M.
   Mohamad, Maysm N.
   Hashim, Mona
   Stojanovska, Lily
   Al Daour, Rameez
   Nader, Dalal
   Alrayis, Hanoof
   Alzaabi, Nouf Sultan
   Elbarag, Lojain
   Binkhadim, Shaikha
   Jarrar, Amjad H.
   Al Dhaheri, Ayesha S.
   Hasan, Hayder
TI Psychosocial factors affecting dietary habits of university students: A
   cross-sectional study
SO HELIYON
LA English
DT Article
DE Body mass index; Eating habits; University students; Psychosocial
   factors
ID METABOLIC SYNDROME; PHYSICAL-ACTIVITY; EATING BEHAVIOR; STRESS;
   PREVALENCE; METAANALYSIS; PERCEPTIONS; POPULATION; FEMALES; OBESITY
AB Background: University student transition from living at home to more independent living which might influence their eating habits. This study aims to assess the effect of psychosocial factors on eating habits among university students. Methods: A cross-sectional study was conducted among 529 students at the University of Sharjah. Participants completed a self-administered questionnaire on dietary habits, social, and psychological factors. The height and weight were also measured. Results: More than one-third of participants were classified as overweight or obese (37.6%) and 39.1% reported not engaging in regular physical activity. Less than half of the participants consumed breakfast daily (45.4%) and 83.2% consumed less than two liters of water per day. Only 28.7% and 34.0% of participants consumed fruits and vegetables daily, respectively. Almost 80% of participants reported eating when they were bored, 83.7% ate when feeling happy, and 56.5% ate when they were sad. Eating habits score was significantly lower among unmarried participants (p = 0.03), those not living with their family (p < 0.001), smokers (p = 0.001), those not engaging in regular physical activity (p < 0.001), and those who reported eating uncontrollably (p = 0.007). Conclusions: Psychosocial factors were important indicators of dietary habits among students. Implementing nutrition education campaigns and health-related courses at the university are recommended.
C1 [Ismail, Leila Cheikh; Osaili, Tareq M.; Hashim, Mona; Al Daour, Rameez; Nader, Dalal; Alrayis, Hanoof; Alzaabi, Nouf Sultan; Elbarag, Lojain; Binkhadim, Shaikha; Hasan, Hayder] Univ Sharjah, Coll Hlth Sci, Dept Clin Nutr & Dietet, Sharjah, U Arab Emirates.
   [Ismail, Leila Cheikh] Univ Oxford, Nuffield Dept Womens & Reprod Hlth, Oxford OX1 2JD, England.
   [Osaili, Tareq M.] Jordan Univ Sci & Technol, Fac Agr, Dept Nutr & Food Technol, Irbid 22110, Jordan.
   [Mohamad, Maysm N.; Stojanovska, Lily; Jarrar, Amjad H.; Al Dhaheri, Ayesha S.] United Arab Emirates Univ, Coll Med & Hlth Sci, Dept Nutr & Hlth, Al Ain 15551, U Arab Emirates.
   [Hashim, Mona] Univ Sains Malaysia, Sch Hlth Sci, Nutr & Dietet Program, Kubang Kerian 16150, Kelantan, Malaysia.
   [Stojanovska, Lily] Victoria Univ, Inst Hlth & Sport, Melbourne 14428, Australia.
C3 University of Sharjah; University of Oxford; Jordan University of
   Science & Technology; United Arab Emirates University; Universiti Sains
   Malaysia; Victoria University
RP Ismail, LC (corresponding author), Univ Sharjah, Coll Hlth Sci, Dept Clin Nutr & Dietet, Sharjah, U Arab Emirates.; Ismail, LC (corresponding author), Univ Oxford, Nuffield Dept Womens & Reprod Hlth, Oxford OX1 2JD, England.
EM lcheikhismail@sharjah.ac.ae
RI Mohamad, Maysm/AAG-4203-2020; Hasan, Hayder/J-4620-2019
OI Hashim, Mona/0000-0002-3494-4718; N Mohamad, Maysm/0000-0002-6396-6625;
   Hasan, Hayder/0000-0001-5580-1911; Cheikh Ismail,
   Leila/0000-0003-3048-7481
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NR 55
TC 9
Z9 9
U1 8
U2 29
PU CELL PRESS
PI CAMBRIDGE
PA 50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA
EI 2405-8440
J9 HELIYON
JI Heliyon
PD JUN
PY 2022
VL 8
IS 6
AR e09768
DI 10.1016/j.heliyon.2022.e09768
PG 7
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 3E8QY
UT WOS:000830244500003
PM 35789869
OA Green Published
DA 2025-06-11
ER

PT J
AU Zhang, Q
   Li, XM
   Qiao, S
   Liu, SF
   Shen, ZY
   Zhou, YJ
AF Zhang, Quan
   Li, Xiaoming
   Qiao, Shan
   Liu, Shuaifeng
   Shen, Zhiyong
   Zhou, Yuejiao
TI Association between hair cortisol, hair cortisone, and fatigue in people
   living with HIV
SO STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS
LA English
DT Article
DE Fatigue; hypothalamic-pituitary-adrenal axis; glucocorticoid; hair
   cortisol; hair cortisone; people living with HIV
ID QUALITY-OF-LIFE; INTRAINDIVIDUAL STABILITY; ANTIRETROVIRAL THERAPY;
   METABOLIC SYNDROME; SALIVARY CORTISOL; PHYSICAL-ACTIVITY; INFECTED
   PATIENTS; URINARY CORTISOL; MEDICAL OUTCOMES; BASAL CORTISOL
AB Cumulative evidence to date largely supports an association between dysregulation of the activity of the hypothalamic-pituitary-adrenal (HPA) axis and fatigue. People living with HIV (PLHIV), in particular, are vulnerable to both HPA axis dysregulation and fatigue. Few investigations have examined the possible role of HPA-axis dysfunction in the occurrence of fatigue in PLHIV. This cross-sectional study aimed to investigate the association between glucocorticoids in hair, retrospective indicators of long-term HPA axis activity and biomarkers of chronic stress, and fatigue in PLHIV. A total of 446 PLHIV from Guangxi China provided hair samples for cortisol and cortisone assay and provided information on fatigue levels, sociodemographic, lifestyle, and HIV-related characteristics. Results showed that before and after controlling sociodemographic, lifestyle, and HIV-related characteristics, hair cortisone levels, but not hair cortisol levels, were associated with fatigue levels in PLHIV. In conclusion, we found that higher cortisone levels are associated with greater fatigue levels in a large cohort of Chinese PLHIV.LAY SUMMARY We found that hair cortisone levels were significantly associated with fatigue levels in a large cohort of Chinese PLHIV. Hair cortisol levels were, however, not associated with fatigue levels in the PLHIV studied. We thus show that Chinese PLHIV who have higher cortisone levels are associated with higher fatigue levels.
C1 [Zhang, Quan; Li, Xiaoming; Qiao, Shan] Univ South Carolina, South Carolina SmartState Ctr Healthcare Qual CHQ, Arnold Sch Publ Hlth, Discovery 1,915 Greene St, Columbia, SC 29028 USA.
   [Zhang, Quan] Hohai Univ, Sch Publ Adm, Inst Pedag & Appl Psychol, Nanjing, Peoples R China.
   [Liu, Shuaifeng; Shen, Zhiyong; Zhou, Yuejiao] Guangxi Zhuang Autonomous Reg Ctr Dis Control & P, Nanning, Peoples R China.
C3 University of South Carolina System; University of South Carolina
   Columbia; Hohai University
RP Zhang, Q (corresponding author), Univ South Carolina, South Carolina SmartState Ctr Healthcare Qual CHQ, Arnold Sch Publ Hlth, Discovery 1,915 Greene St, Columbia, SC 29028 USA.
EM quanz@mailbox.sc.edu
RI Li, Huihuang/GNM-7727-2022; Zhang, Quan/ABF-9541-2020
OI Zhang, Quan/0000-0001-6028-6977; Qiao, Shan/0000-0003-1834-1834
FU National Institutes of Health (NIH) Research Grant [R01HD074221,
   R21AI122919]
FX This work was supported by the National Institutes of Health (NIH)
   Research Grant [Grant numbers R01HD074221, R21AI122919].
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NR 66
TC 5
Z9 6
U1 1
U2 11
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1025-3890
EI 1607-8888
J9 STRESS
JI Stress
PD NOV 2
PY 2021
VL 24
IS 6
BP 772
EP 779
DI 10.1080/10253890.2021.1919616
EA APR 2021
PG 8
WC Behavioral Sciences; Endocrinology & Metabolism; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Behavioral Sciences; Endocrinology & Metabolism; Neurosciences &
   Neurology
GA YJ1QF
UT WOS:000646836500001
PM 33913374
OA Bronze
DA 2025-06-11
ER

PT J
AU Herman, BA
   Ferguson, KM
   Fernandez, JVB
   Kauffman, S
   Spicher, JT
   King, RJ
   Halterman, JA
AF Herman, Braden A.
   Ferguson, Kaylee M.
   Fernandez, Jared V. B.
   Kauffman, Samantha
   Spicher, Jason T.
   King, Rachel J.
   Halterman, Julia A.
TI NFAT5 is differentially expressed in Sprague-Dawley rat tissues
   in response to high salt and high fructose diets
SO GENETICS AND MOLECULAR BIOLOGY
LA English
DT Article
DE NFAT5; aldose reductase; salt; fructose; real-time PCR
ID ENHANCER-BINDING PROTEIN; TRANSCRIPTION FACTOR TONEBP; ENDOTHELIAL
   GROWTH-FACTOR; ALDOSE REDUCTASE; OSMOTIC-STRESS; BLOOD-PRESSURE;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; GENE-EXPRESSION; SODIUM
AB Current diets contain an increasing amount of salt and high fructose corn syrup, but it remains unclear as to how dietary salt and fructose affect organ function at the molecular level. This study aimed to test the hypothesis that consumption of high salt and fructose diets would increase tissue-specific expression of two critical osmotically-regulated genes, nuclear factor of activated T-cells 5 (NFAT5) and aldose reductase (AR). Fifty Sprague-Dawley rats were placed on a control, 4% NaCl, 8% NaCl, or 64% fructose diet for eight weeks. Fourteen different tissue samples were harvested and snap-frozen, followed by RNA purification, cDNA synthesis, and NFAT5 and AR gene expression quantification by real-time PCR.Our findings demonstrate that NFAT5 and AR expression are up-regulated in the kidney medulla, liver, brain, and adipose tissue following consumption of a high salt diet. NFAT5 expression is also up-regulated in the kidney cortex following consumption of a 64% fructose diet. These findings highlight the kidney medulla, liver, brain, and adipose tissue as being "salt-responsive" tissues and reveal that a high fructose diet can lead to enhanced NFAT5 expression in the kidney cortex. Further characterization of signaling mechanisms involved could help elucidate how these diets affect organ function long term.
C1 [Herman, Braden A.; Ferguson, Kaylee M.; Kauffman, Samantha; Spicher, Jason T.; King, Rachel J.; Halterman, Julia A.] Eastern Mennonite Univ, Dept Biol, 1200 Pk Rd, Harrisonburg, VA 22802 USA.
   [Fernandez, Jared V. B.; Halterman, Julia A.] Eastern Mennonite Univ, Masters Biomed Program, Harrisonburg, VA 22802 USA.
RP Halterman, JA (corresponding author), Eastern Mennonite Univ, Dept Biol, 1200 Pk Rd, Harrisonburg, VA 22802 USA.
EM julia.halterman@emu.edu
RI Herman, Braden/AFN-8561-2022
FU Thomas F. and Kate Miller Jeffress Memorial Trust, Bank of America,
   Trustee
FX This research was funded by The Thomas F. and Kate Miller Jeffress
   Memorial Trust, Bank of America, Trustee.
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NR 46
TC 2
Z9 2
U1 0
U2 2
PU SOC BRASIL GENETICA
PI RIBEIRAO PRET
PA RUA CAP ADELMIO NORBET DA SILVA, 736, ALTO DA BOA VISTA, 14025-670
   RIBEIRAO PRET, BRAZIL
SN 1415-4757
EI 1678-4685
J9 GENET MOL BIOL
JI Genet. Mol. Biol.
PD APR-JUN
PY 2019
VL 42
IS 2
BP 452
EP 464
DI 10.1590/1678-4685-GMB-2018-0120
PG 13
WC Biochemistry & Molecular Biology; Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Genetics & Heredity
GA IU9VF
UT WOS:000483927900016
PM 30816906
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Gorini, S
   Marzolla, V
   Mammi, C
   Armani, A
   Caprio, M
AF Gorini, Stefania
   Marzolla, Vincenzo
   Mammi, Caterina
   Armani, Andrea
   Caprio, Massimiliano
TI Mineralocorticoid Receptor and Aldosterone-Related Biomarkers of
   End-Organ Damage in Cardiometabolic Disease
SO BIOMOLECULES
LA English
DT Review
DE mineralocorticoid receptor; aldosterone; PBMC; NGAL; Gal-3; PTGDS;
   adipose tissue
ID GELATINASE-ASSOCIATED LIPOCALIN; LEFT-VENTRICULAR DYSFUNCTION;
   II-INDUCED HYPERTENSION; SODIUM-CHANNEL ENAC; CD8(+) T-CELLS;
   NF-KAPPA-B; ADIPOSE-TISSUE; METABOLIC SYNDROME; OXIDATIVE STRESS;
   ANGIOTENSIN-II
AB The mineralocorticoid receptor (MR) was first identified as a blood pressure regulator, modulating renal sodium handling in response to its principal ligand aldosterone. The mineralocorticoid receptor is also expressed in many tissues other than the kidney, such as adipose tissue, heart and vasculature. Recent studies have shown that MR plays a relevant role in the control of cardiovascular and metabolic function, as well as in adipogenesis. Dysregulation of aldosterone/MR signaling represents an important cause of disease as high plasma levels of aldosterone are associated with hypertension, obesity and increased cardiovascular risk. Aldosterone displays powerful vascular effects and acts as a potent pro-fibrotic agent in cardiovascular remodeling. Mineralocorticoid receptor activation regulates genes involved in vascular and cardiac fibrosis, calcification and inflammation. This review focuses on the role of novel potential biomarkers related to aldosterone/MR system that could help identify cardiovascular and metabolic detrimental conditions, as a result of altered MR activation. Specifically, we discuss: (1) how MR signaling regulates the number and function of different subpopulations of circulating and intra-tissue immune cells; (2) the role of aldosterone/MR system in mediating cardiometabolic diseases induced by obesity; and (3) the role of several MR downstream molecules as novel potential biomarkers of cardiometabolic diseases, end-organ damage and rehabilitation outcome.
C1 [Gorini, Stefania; Marzolla, Vincenzo; Mammi, Caterina; Armani, Andrea; Caprio, Massimiliano] IRCCS San Raffaele Pisana, Lab Cardiovasc Endocrinol, Via Val Cannuta 247, I-00166 Rome, Italy.
   [Caprio, Massimiliano] San Raffaele Roma Open Univ, Dept Human Sci & Promot Qual Life, I-00166 Rome, Italy.
C3 IRCCS San Raffaele Pisana
RP Caprio, M (corresponding author), IRCCS San Raffaele Pisana, Lab Cardiovasc Endocrinol, Via Val Cannuta 247, I-00166 Rome, Italy.; Caprio, M (corresponding author), San Raffaele Roma Open Univ, Dept Human Sci & Promot Qual Life, I-00166 Rome, Italy.
EM stefania.gorini@sanraffaele.it; vincenzo.marzolla@sanraffaele.it;
   caterina.mammi@sanraffaele.it; andrea.armani@sanraffaele.it;
   massimiliano.caprio@sanraffaele.it
RI Mammi, Caterina/O-1047-2013; Armani, Andrea/AAC-2071-2022; gorini,
   stefania/ABI-6853-2020; Marzolla, Vincenzo/K-7769-2016; Caprio,
   Massimiliano/J-3020-2012
OI mammi, caterina/0000-0002-2687-4422; ARMANI, Andrea/0000-0002-2130-1596;
   Marzolla, Vincenzo/0000-0002-2943-7631; Caprio,
   Massimiliano/0000-0003-0722-7163
FU Italian Ministry of Health; MIUR [2015ZTT5KB]
FX This research was funded by the Italian Ministry of Health (Ricerca
   Corrente and Bando 2011-2012 Progetti Collaborazione Ricercatori
   Italiani all'Estero, to M.C.) and by MIUR (Progetti di Ricerca di
   interesse Nazionale 2015-project code 2015ZTT5KB, to M.C., work package
   leader).
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NR 168
TC 24
Z9 24
U1 0
U2 8
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2218-273X
J9 BIOMOLECULES
JI Biomolecules
PD SEP
PY 2018
VL 8
IS 3
AR 96
DI 10.3390/biom8030096
PG 20
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA GY2SZ
UT WOS:000448394900054
PM 30231508
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Ando, M
   Matsumoto, T
   Kobayashi, S
   Iguchi, M
   Taguchi, K
   Kobayashi, T
AF Ando, Makoto
   Matsumoto, Takayuki
   Kobayashi, Shota
   Iguchi, Maika
   Taguchi, Kumiko
   Kobayashi, Tsuneo
TI Impairment of Protease-Activated Receptor 2-Induced Relaxation of Aortas
   of Aged Spontaneously Hypertensive Rat
SO BIOLOGICAL & PHARMACEUTICAL BULLETIN
LA English
DT Article
DE aorta; endothelium; hypertension; protease-activated receptor 2 (PAR2);
   relaxation
ID ENDOTHELIUM-DEPENDENT RELAXATION; METABOLIC SYNDROME; NITRIC-OXIDE;
   OXIDATIVE STRESS; VASODILATION; ARTERY; ENOS; MECHANISMS; EXPRESSION;
   ADENOSINE
AB Hypertension is one of the most prevalent diseases worldwide and can cause harmful complications within the vascular system. Further research on vascular responsiveness to different ligands and diverse receptors in various arteries is required to understand the mechanisms underlying the development of these vascular complications. Here, we investigated the vasorelaxant effect of the protease-activated receptor 2 (PAR2) agonist 2-furoyl-LIGRLO-amide (2-Fly) and two commonest agents, namely endothelium-dependent dilator acetylcholine (ACh) and endothelium-independent dilator sodium nitroprusside (SNP), on the thoracic aorta isolated from aged spontaneously hypertensive rats (SHR) (age, 52 +/- 1 weeks). The effects of these agents were compared between aortas isolated from SHR and age-matched normotensive Wistar Kyoto (WKY) rats. Compared with the WKY group, in the SHR group, 2-Fly-induced relaxation was impaired, ACh-induced relaxation was slightly decreased at low concentrations, and SNP-induced relaxation was similar. In addition, 2-Fly-induced aortic relaxation was largely decreased by a PAR2 antagonist (FSLLRY), endothelial denudation, and a nitric oxide (NO) synthase inhibitor N-G-nitro-L-arginine (L-NNA) but not by an Akt inhibitor. These results suggested that PAR2-induced relaxations of aortas of aged SHR was impaired, and this impaired aortic relaxation may be attributed to decreased NO bioavailability rather than altered NO sensitivity unrelated to the Akt activity.
C1 [Ando, Makoto; Matsumoto, Takayuki; Kobayashi, Shota; Iguchi, Maika; Taguchi, Kumiko; Kobayashi, Tsuneo] Hoshi Univ, Inst Med Chem, Dept Physiol & Morphol, Shinagawa Ku, 2-4-1 Ebara, Tokyo 1428501, Japan.
C3 Hoshi University
RP Kobayashi, T (corresponding author), Hoshi Univ, Inst Med Chem, Dept Physiol & Morphol, Shinagawa Ku, 2-4-1 Ebara, Tokyo 1428501, Japan.
EM tkoba@hoshi.ac.jp
RI Matsumoto, Takayuki/KPA-2027-2024
OI Ando, Makoto/0000-0003-1836-8885
FU JSPS KAKENHI [JP17K07975, JP15K07975]
FX We thank Mr. K. Takayanagi, Mrs. M. Kojima, Mr. M. Ichikawa, Mrs. M.
   Iwasaki, Mr. S. Ohira, Mrs. K. Taguchi, Mr. S. Noguchi, Mrs. K. Hatano,
   and Mrs. Y. Higashida for technical assistance. This study was supported
   in part by JSPS KAKENHI Grants JP17K07975 to K.T. and JP15K07975 to T.K.
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NR 38
TC 3
Z9 4
U1 0
U2 4
PU PHARMACEUTICAL SOC JAPAN
PI TOKYO
PA 2-12-15 SHIBUYA, SHIBUYA-KU, TOKYO, 150-0002, JAPAN
SN 0918-6158
J9 BIOL PHARM BULL
JI Biol. Pharm. Bull.
PD MAY
PY 2018
VL 41
IS 5
BP 815
EP 819
DI 10.1248/bpb.b17-00987
PG 5
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA GE3FM
UT WOS:000431099200020
PM 29709920
OA gold
DA 2025-06-11
ER

PT J
AU Jain, A
   Puri, R
   Nair, DR
AF Jain, Anjly
   Puri, Rajeev
   Nair, Devaki R.
TI South Asians: why are they at a higher risk for cardiovascular disease?
SO CURRENT OPINION IN CARDIOLOGY
LA English
DT Review
DE blood pressure; cardiovascular disease; cerebrovascular disease;
   endothelial dysfunction; lipids; South Asian; thrombotic factors
ID CORONARY-HEART-DISEASE; FATTY LIVER-DISEASE; PHYSICAL-ACTIVITY;
   ETHNIC-DIFFERENCES; METABOLIC SYNDROME; ADIPOSE-TISSUE; BLOOD-PRESSURE;
   INDIANS; ASSOCIATION; GENE
AB Purpose of reviewWe comment on the high prevalence of cardiovascular disease (CVD) in South Asians (SA). The effect of various risk factors, for example biochemical, genetic, lifestyle, socioeconomic factors and psychosocial stress on CVD risk is discussed.Recent findingsPrediabetes' is common in SA, but its relationship with coronary artery disease (CAD) is not significant unlike for the white population. At the same time, prediabetes' in SA is associated with an increased risk for cerebrovascular disease (CeVD). The differentiating factor could be the high lipids in Europeans and their relationship to CAD. Likewise, higher diastolic blood pressure in SA may explain the risk of CeVD. Small, dense, low-density lipoprotein (LDL), low high-density lipoprotein-cholesterol (HDL-C) concentration and high triglycerides may contribute to atherosclerosis. Thrombotic factors such as increased levels of plasminogen activator inhibitor, fibrinogen, lipoprotein (a) and homocysteine have been shown to be associated with increased CVD. Impaired cerebrovascular autoregulation and sympathovagal activity, increased arterial stiffness and endothelial dysfunction may increase CVD risk further. In addition, environmental and dietary factors may exaggerate the unfavourable cardiovascular profile through genetic factors.SummaryThe implications of the findings suggest comprehensive screening of SA for CVD. Cultural differences should be considered while designing prevention strategies specifically targeting barriers for uptake of preventive service.
C1 [Jain, Anjly; Nair, Devaki R.] Royal Free London NHS Fdn Trust, Dept Clin Biochem, London, England.
   [Puri, Rajeev] Indraprastha Apollo Hosp, New Delhi, India.
C3 University of London; University College London; Royal Free London NHS
   Foundation Trust
RP Nair, DR (corresponding author), Royal Free Hosp, Clin Biochem Royal Free & North Middlesex, Pond St, London NW3 2QG, England.; Nair, DR (corresponding author), Royal Free Hosp, Lipids & Cardiovasc Prevent, Pond St, London NW3 2QG, England.; Nair, DR (corresponding author), Royal Free Hosp, SAS Ctr Cardiac Biomarkers, Pond St, London NW3 2QG, England.
EM Devaki.Nair@nhs.net
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NR 80
TC 17
Z9 17
U1 0
U2 11
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0268-4705
EI 1531-7080
J9 CURR OPIN CARDIOL
JI Curr. Opin. Cardiol.
PD JUL
PY 2017
VL 32
IS 4
BP 430
EP 436
DI 10.1097/HCO.0000000000000411
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA EX2VC
UT WOS:000403086200013
PM 28505046
DA 2025-06-11
ER

PT J
AU Piao, GC
   Liu, GC
   Jin, XJ
   Jin, D
   Yuan, HD
AF Piao, Guang-Chun
   Liu, Guan-Cheng
   Jin, Xue-Jun
   Jin, Dan
   Yuan, Hai-Dan
TI Tetrahydropalmatine inhibits lipid accumulation through AMPK signaling
   pathway in 3T3-L1 adipocytes
SO MOLECULAR MEDICINE REPORTS
LA English
DT Article
DE tetrahydropalmatine; AMP-activated protein kinase; 3T3L1 adipocyte;
   adipogenesis
ID ACTIVATED PROTEIN-KINASE; METABOLIC SYNDROME; ADIPOSE-TISSUE;
   ADIPOGENESIS; CORYDALIS; DIFFERENTIATION; YANHUSUO; EXTRACT; STRESS;
   CELLS
AB Tetrahydropalmatine (THP), one of the active components of Rhizoma corydalis, has been reported to exert several pharmacological effects, including anti-inflammatory, anti-tumor and analgesic activities. However, its effect on obesity and the underlying molecular mechanisms that may be involved have not yet been elucidated. In the present study, the inhibitory effects of THP on the adipogenesis in 3T3-L1 adipocytes was examined using hstology, western blotting and RT-qPCR. THP was identified to significantly suppress lipid accumulation in 3T3-L1 cells and it inhibited pre-adipocyte differentiation in a concentration-dependent manner, as evidenced by the reduced formation of lipid droplets and decreased triglyceride levels and glycerol-3-phosphate dehydrogenase activity. THP downregulated the adipogenesis-associated protein and gene expressions of sterol regulatory element-binding protein 1, fatty acid synthase, stearoyl-CoA desaturase 1, peroxisome proliferator activated receptor gamma and CCAAT/enhancer binding protein-alpha in a concentration-dependent manner. In addition, it reduced adipocyte fatty acid binding protein and glycerol-3-phosphate acyltransferase gene expression in a concentration-dependent manner. Conversely, THP increased the mRNA expression of carnitine palmitoyltransferase 1 in a concentration-dependent manner. Furthermore, THP increased AMP-activated protein kinase (AMPK) and acetyl-CoA carboxylase phosphorylation in a concentration-dependent manner. These results suggested that anti-adipogenic activity of TPH may be mediated via the AMPK pathway in 3T3-L1 cells.
C1 [Piao, Guang-Chun; Liu, Guan-Cheng; Jin, Xue-Jun; Jin, Dan; Yuan, Hai-Dan] Yanbian Univ, Minist Educ, Coll Pharm, Key Lab Nat Resources Changbai Mt & Funct Mol, 977 Gongyuan St, Yanji 133002, Jilin, Peoples R China.
C3 Yanbian University; Ministry of Education - China
RP Yuan, HD (corresponding author), Yanbian Univ, Minist Educ, Coll Pharm, Key Lab Nat Resources Changbai Mt & Funct Mol, 977 Gongyuan St, Yanji 133002, Jilin, Peoples R China.
EM hdyuan@ybu.edu.cn
RI JIN, Xuejun/J-1442-2012
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NR 26
TC 10
Z9 12
U1 1
U2 32
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1791-2997
EI 1791-3004
J9 MOL MED REP
JI Mol. Med. Rep.
PD JUN
PY 2017
VL 15
IS 6
BP 3912
EP 3918
DI 10.3892/mmr.2017.6473
PG 7
WC Oncology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Research & Experimental Medicine
GA EU5LA
UT WOS:000401071600065
PM 28440456
OA hybrid, Green Submitted
DA 2025-06-11
ER

PT J
AU Bian, O
   Zhang, HS
   Guan, QG
   Sun, YX
   Zeng, DY
AF Bian, Ou
   Zhang, Haishan
   Guan, Qigang
   Sun, Yingxian
   Zeng, Dingyin
TI High-dose insulin inhibits gap junction intercellular communication in
   vascular smooth muscle cells
SO MOLECULAR MEDICINE REPORTS
LA English
DT Article
DE insulin; vascular smooth muscle cell; gap junction intercellular
   communication; connexin 43
ID CONNEXIN EXPRESSION; HYDROGEN-PEROXIDE; IN-VITRO; RESISTANCE;
   PROLIFERATION; HYPERINSULINEMIA; GLUCOSE; PHOSPHORYLATION; MIGRATION;
   RECEPTOR
AB Gap junction intercellular communication (GJIC) is important in mediating intercellular substance and signal transmission. Connexin (Cx)43 is a major component involved in GJIC in vascular tissue and its abnormal expression is closely associated with various vascular diseases. Insulin resistance is the central component of metabolic syndrome, and high doses of insulin can affect vascular function through multiple pathways, resulting in cardiovascular disease. However, the effects of insulin on GJIC function and connexin (Cx)43 expression in vascular smooth muscle cells (VSMCs) remain unclear. Following treatment of VSMCs with different doses of insulin, a fluorescence recovery after photobleaching (FRAP) assay was performed to evaluate GJIC function in treated VSMCs. The results showed that high-dose insulin suppressed GJIC function. Western blot assays further demonstrated that high-dose insulin induced the phosphorylation of Cx43 at s368 and downregulated the expression of Cx43. H2O2 release assays demonstrated that high-dose insulin treatment significantly elevated the cellular H2O2 level. In addition, compared with cells treated with high-dose insulin, pretreatment with catalase significantly restored the cellular GJIC function, decreased the phosphorylation level of Cx43 at s368, and enhanced Cx43 expression. In conclusion, these data indicate that high-dose insulin inhibits cellular GJIC function through the oxidative stress-activated signaling pathway. This phenomenon may also constitute a potential mechanism underlying the pathogenesis of insulin resistance and its complications.
C1 [Bian, Ou; Zhang, Haishan; Guan, Qigang; Sun, Yingxian; Zeng, Dingyin] China Med Univ, Affiliated Hosp 1, Dept Cardiol, Shenyang 110001, Liaoning, Peoples R China.
C3 China Medical University
RP Sun, YX (corresponding author), China Med Univ, Affiliated Hosp 1, Dept Cardiol, 155 North Nanjing, Shenyang 110001, Liaoning, Peoples R China.
EM yingxiansun@hotmail.com; dingyin_zeng@163.com
RI Sun, Yingxian/KHT-6171-2024
OI Sun, Yingxian/0000-0002-1961-899X
FU National Basic Research Program of China (973 Program) [2012CB518606]
FX This study was supported by a grant from the National Basic Research
   Program of China (973 Program, no. 2012CB518606).
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NR 47
TC 8
Z9 8
U1 0
U2 6
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1791-2997
EI 1791-3004
J9 MOL MED REP
JI Mol. Med. Rep.
PD JUL
PY 2015
VL 12
IS 1
BP 331
EP 336
DI 10.3892/mmr.2015.3437
PG 6
WC Oncology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Research & Experimental Medicine
GA CN0WJ
UT WOS:000358134400047
PM 25760256
OA Bronze
DA 2025-06-11
ER

PT J
AU Yue, Y
   Wu, SC
   Li, ZK
   Li, J
   Li, XF
   Xiang, J
   Ding, H
AF Yue, Yuan
   Wu, Shuangchan
   Li, Zhike
   Li, Jian
   Li, Xiaofei
   Xiang, Jin
   Ding, Hong
TI Wild jujube polysaccharides protect against experimental inflammatory
   bowel disease by enabling enhanced intestinal barrier function
SO FOOD & FUNCTION
LA English
DT Article
ID TIGHT JUNCTION PROTEINS; NECROSIS-FACTOR-ALPHA; CACO-2 CELL MONOLAYERS;
   EPITHELIAL BARRIER; TNF-ALPHA; ULCERATIVE-COLITIS; METABOLIC SYNDROME;
   OXIDATIVE STRESS; RAT MODEL; KINASE
AB Dietary polysaccharides provide various beneficial effects for our health. We investigated the protective effects of wild jujube (Ziziphus jujuba Mill. var. spinosa (Bunge) Hu ex H. F. Chou) sarcocarp polysaccharides (WJPs) against experimental inflammatory bowel disease (IBD) by enabling enhanced intestinal barrier function. Colitis was induced in rats by the intrarectal administration of TNBS. We found that WJPs markedly ameliorated the colitis severity, including less weight loss, decreased disease activity index scores, and improved mucosal damage in colitis rats. Moreover, WJPs suppressed the inflammatory response via attenuation of TNF-alpha, IL-1 beta, IL- 6 and MPO activity in colitis rats. And then, to determine the effect of WJPs on the intestinal barrier, we measured the effect of WJPs on the transepithelial electrical resistance (TER) and FITC-conjugated dextran permeability in Caco-2 cell stimulation with TNF-alpha. We further demonstrated that the alleviation of WJPs to colon injury was associated with barrier function by assembly of tight junction proteins. Moreover, the effect of WJPs on TER was eliminated by the specific inhibitor of AMPK. AMPK activity was also up-regulated by WJPs in Caco-2 cell stimulation with TNF-alpha and in colitis rats. This study demonstrates that WJPs protect against IBD by enabling enhanced intestinal barrier function involving the activation of AMPK.
C1 [Yue, Yuan; Wu, Shuangchan; Li, Zhike; Li, Jian; Li, Xiaofei; Xiang, Jin; Ding, Hong] Wuhan Univ, Key Lab Combinatorial Biosynth & Drug Discovery, Minist Educ, Sch Pharmaceut Sci, Wuhan 430072, Peoples R China.
C3 Wuhan University; Ministry of Education - China
RP Yue, Y (corresponding author), Wuhan Univ, Key Lab Combinatorial Biosynth & Drug Discovery, Minist Educ, Sch Pharmaceut Sci, Wuhan 430072, Peoples R China.
EM dinghong1106@whu.edu.cn
RI Li, xiaofei/GXF-7187-2022; li, zi/AAH-2494-2019
OI Wu, Shuangchan/0000-0001-6140-0196
FU National Natural Science Foundation of China [81273523]
FX This work was supported by the National Natural Science Foundation of
   China (81273523).
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NR 51
TC 74
Z9 81
U1 2
U2 143
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PY 2015
VL 6
IS 8
BP 2568
EP 2577
DI 10.1039/c5fo00378d
PG 10
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA CO4KD
UT WOS:000359128700014
PM 26114600
DA 2025-06-11
ER

PT J
AU Ren, DY
   Zhao, Y
   Nie, Y
   Yang, NN
   Yang, XB
AF Ren, Daoyuan
   Zhao, Yan
   Nie, Yan
   Yang, Nana
   Yang, Xingbin
TI Hypoglycemic and hepatoprotective effects of polysaccharides from
   Artemisia sphaerocephala Krasch seeds
SO INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
LA English
DT Article
DE Artemisia sphaerocephala Krasch; Polysaccharides; HPLC; Hyperglycemia;
   Liver damage
ID HIGH-FRUCTOSE-DIET; INDUCED INSULIN-RESISTANCE; TYPE-2 DIABETIC-RATS;
   FATTY LIVER-DISEASE; TEA POLYSACCHARIDES; OXIDATIVE STRESS;
   GYNOSTEMMA-PENTAPHYLLUM; METABOLIC SYNDROME; HOMEOSTASIS MODEL;
   PLEUROTUS-ERYNGII
AB Intake of dietary high fructose (HF) exerts a number of adverse metabolic effects. The present study was to investigate whether Artemisia sphaerocephala Krasch seed polysaccharides (ASKP) alleviated hyperglycemia, hepatic steatosis and oxidative injury in mice fed HF water. After 8 weeks of the experiment, administration of ASKP at 400 and 800 mg/kg bw significantly reduced the fasting serum glucose, insulin concentrations and the homeostasis model assessment of basal insulin resistance (HOMA-IR) of the mice fed 20% HF water. In the oral glucose tolerance test, the administration of ASKP at 400 and 800 mg/kg bw had a reduced plasma glucose concentrations after 15 min of glucose loading in HF-fed mice, indicating that ASKP improved glucose intolerance. ASKP also remarkably ameliorated the HF-induced elevation of liver lipid contents and oxidative injury in mice, and caused the reduction of liver lipid peroxidation and the elevation of hepatic antioxidant system. Histopathology of the liver by conventional H&E and Oil Red O staining confirmed the liver steatosis and oxidative injury induced by HF diet and the hepatoprotective effect of ASKP. This is the first report showing that ASKP can ameliorate the high fructose-induced hyperglycemia, hepatic steatosis and oxidative injury. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Ren, Daoyuan; Nie, Yan; Yang, Nana; Yang, Xingbin] Shaanxi Normal Univ, Coll Food Engn & Nutr Sci, Key Lab Minist Educ Med Resource & Nat Pharmaceut, Xian 710062, Peoples R China.
   [Zhao, Yan] Fourth Mil Med Univ, Sch Pharm, Xian 710032, Peoples R China.
C3 Shaanxi Normal University; Air Force Medical University
RP Yang, XB (corresponding author), Shaanxi Normal Univ, Coll Food Engn & Nutr Sci, Key Lab Minist Educ Med Resource & Nat Pharmaceut, Xian 710062, Peoples R China.
EM xbyang@snnu.edu.cn
FU National Natural Science Foundation of China [C31171678]; Fundamental
   Research Funds for the Central Universities of Shaanxi Normal
   University, China [GK201103004]
FX This study was supported by the grants from the National Natural Science
   Foundation of China (C31171678), and the Fundamental Research Funds for
   the Central Universities of Shaanxi Normal University, China
   (GK201103004).
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NR 36
TC 48
Z9 53
U1 0
U2 62
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0141-8130
EI 1879-0003
J9 INT J BIOL MACROMOL
JI Int. J. Biol. Macromol.
PD AUG
PY 2014
VL 69
BP 296
EP 306
DI 10.1016/j.ijbiomac.2014.05.064
PG 11
WC Biochemistry & Molecular Biology; Chemistry, Applied; Polymer Science
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry; Polymer Science
GA AN1DO
UT WOS:000340323100042
PM 24887549
DA 2025-06-11
ER

PT J
AU Trasande, L
   Sathyanarayana, S
   Spanier, AJ
   Trachtman, H
   Attina, TM
   Urbina, EM
AF Trasande, Leonardo
   Sathyanarayana, Sheela
   Spanier, Adam J.
   Trachtman, Howard
   Attina, Teresa M.
   Urbina, Elaine M.
TI Urinary Phthalates Are Associated with Higher Blood Pressure in
   Childhood
SO JOURNAL OF PEDIATRICS
LA English
DT Article
ID EXAMINATION-SURVEY NHANES; BODY-MASS INDEX; ENDOTHELIAL DYSFUNCTION;
   INFLAMMATORY RESPONSE; WAIST CIRCUMFERENCE; METABOLIC SYNDROME;
   OXIDATIVE STRESS; NATIONAL-HEALTH; US POPULATION; RISK-FACTORS
AB Objective To examine associations of urinary phthalate levels with blood pressure (BP) and serum triglyceride and lipoprotein levels in children.
   Study design We performed a cross-sectional analysis of a subsample of US children aged 6-19 years who participated in the National Health and Nutrition Examination Survey between 2003 and 2008. We quantified exposure to 3 families of phthalates-low molecular weight, high molecular weight and di-2-ethylhexylphthalate (DEHP)-based on molar concentration of urinary metabolites. We assessed descriptive, bivariate, and multivariate associations with BP and lipid levels.
   Results Controlling for an array of sociodemographic and behavioral factors, as well as diet and body mass index, levels of metabolites of DEHP, a phthalate commonly found in processed foods, were associated with higher age-, sex-, and height-standardized BP. For each log unit (roughly 3-fold) increase in DEHP metabolites, a 0.041 SD unit increase in systolic BP z-score was identified (P = .047). Metabolites of low molecular weight phthalates commonly found in cosmetics and personal care products were not associated with BP. Phthalate metabolites were not associated with triglyceride levels, high-density lipoprotein level, or prehypertension.
   Conclusions Dietary phthalate exposure is associated with higher systolic BP in children and adolescents. Further work is needed to confirm these associations, as well as to evaluate opportunities for intervention.
C1 [Trasande, Leonardo; Trachtman, Howard; Attina, Teresa M.] NYU, Sch Med, Dept Pediat, New York, NY 10016 USA.
   [Trasande, Leonardo] NYU, Sch Med, Dept Environm Med, New York, NY 10016 USA.
   [Trasande, Leonardo] NYU, Sch Med, Dept Populat Hlth, New York, NY 10016 USA.
   [Trasande, Leonardo] NYU, Wagner Sch Publ Serv, New York, NY 10016 USA.
   [Trasande, Leonardo] NYU, Steinhardt Sch Culture Educ & Human Dev, New York, NY 10016 USA.
   [Sathyanarayana, Sheela] Univ Washington, Dept Pediat, Seattle Childrens Res Inst, Seattle, WA 98195 USA.
   [Spanier, Adam J.] Penn State Univ, Dept Pediat, Hershey, PA USA.
   [Urbina, Elaine M.] Cincinnati Childrens Hosp Med Ctr, Div Prevent Cardiol, Cincinnati, OH 45229 USA.
C3 New York University; New York University; New York University; New York
   University; New York University; Seattle Children's Hospital; University
   of Washington; University of Washington Seattle; Pennsylvania
   Commonwealth System of Higher Education (PCSHE); Pennsylvania State
   University; Penn State Health; Cincinnati Children's Hospital Medical
   Center
RP Trasande, L (corresponding author), NYU, Sch Med, 227 East 30th St,Room 711, New York, NY 10016 USA.
EM Leonardo.trasande@nyumc.org
RI Trasande, Leonardo/ABE-6339-2020; Trachtman, Howard/GSE-2340-2022
FU KiDS of NYU Foundation
FX Supported by the KiDS of NYU Foundation. The authors declare no
   conflicts of interest.
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NR 46
TC 106
Z9 106
U1 1
U2 34
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0022-3476
EI 1097-6833
J9 J PEDIATR-US
JI J. Pediatr.
PD SEP
PY 2013
VL 163
IS 3
BP 747
EP +
DI 10.1016/j.jpeds.2013.03.072
PG 8
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA 212LQ
UT WOS:000323985300030
OA Green Accepted
DA 2025-06-11
ER

PT J
AU San Martín, A
   Du, PF
   Dikalova, A
   Lassègue, B
   Aleman, M
   Góngora, MC
   Brown, K
   Joseph, G
   Harrison, DG
   Taylor, WR
   Jo, H
   Griendling, KK
AF San Martin, Alejandra
   Du, Pingfeng
   Dikalova, Anna
   Lassegue, Bernard
   Aleman, Maria
   Gongora, Maria Carolina
   Brown, Kathryn
   Joseph, Giji
   Harrison, David G.
   Taylor, W. Robert
   Jo, Hanjoong
   Griendling, Kathy K.
TI Reactive oxygen species-selective regulation of aortic inflammatory gene
   expression in Type 2 diabetes
SO AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
LA English
DT Article; Proceedings Paper
CT 9th Cardiovascular-Kidney Interactions in Health and Disease Meeting
CY MAY 26-29, 2006
CL Amelia Isl, FL
DE vascular inflammation; NADPH oxidases; cytokines; superoxide; metabolic
   syndrome
ID TISSUE GROWTH-FACTOR; NADPH OXIDASE INHIBITOR; OXIDATIVE STRESS; NAD(P)H
   OXIDASE; ANGIOTENSIN-II; DIFFERENTIAL EXPRESSION; INSULIN-RESISTANCE;
   ENDOTHELIAL-CELLS; RAT MODEL; OSTEOPONTIN
AB Vascular diseases are a major complication of diabetes mellitus (DM), although their etiology is poorly understood. NADPH oxidase-derived reactive oxygen species (ROS) production and inflammation are potential mediators of DM-associated vascular diseases. Using db/db mice as a Type 2 diabetes model, we examined the relationship between NADPH oxidase-derived ROS and vascular inflammation. When compared with control m+/+ mice, aortas from 4- and 12-wk-old db/db mice had higher NADPH oxidase activity and increased superoxide levels, leading to NADPH oxidase-dependent impaired vasodilation at 12 wk. Diabetes progression from 4 to 12 wk led to increased Nox1, Nox4, and P22(phox) subunit mRNAs and induced the expression of a group of matrix remodeling-related cytokines: connective tissue growth factor (CTGF), bone morphogenetic protein 4 (BMP-4), and osteopontin (OPN). After 8 wk of treatment with the superoxide scavenger Tempol, 12-wk-old db/db mice had lower superoxide production, reduced plasma glucose and lipids, and lower BMP-4 and OPN protein expression when compared with nontreated mice. No changes were observed with Tempol in CTGF or m+/+ mice. The ability of Tempol to reverse ROS production as well as OPN and BMP-4, but not CTGF, induction suggests that DM-induced vascular inflammation involves both ROS-sensitive and -insensitive pathways.
C1 Emory Univ, Dept Med, Div Cardiol, Atlanta, GA 30322 USA.
C3 Emory University
RP Griendling, KK (corresponding author), Emory Univ, Div Cardiol, 319 WMB,1639 Pierce Dr, Atlanta, GA 30322 USA.
EM kgriend@emory.edu
RI Harrison, David/ITT-6732-2023; San Martin, Alejandra/HDN-0012-2022; Jo,
   Hanjoong/L-6216-2019
OI Jo, Hanjoong/0000-0003-1833-372X; San Martin,
   Alejandra/0000-0002-4620-1591; Griendling, Kathy/0000-0002-9456-8582;
   Aleman, Maria M./0000-0002-1714-0363; Lassegue,
   Bernard/0000-0003-4924-6506
FU NHLBI NIH HHS [HL 075209, HL 058000] Funding Source: Medline
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NR 54
TC 112
Z9 122
U1 0
U2 9
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0363-6135
EI 1522-1539
J9 AM J PHYSIOL-HEART C
JI Am. J. Physiol.-Heart Circul. Physiol.
PD MAY
PY 2007
VL 292
IS 5
BP H2073
EP H2082
DI 10.1152/ajpheart.00943.2006
PG 10
WC Cardiac & Cardiovascular Systems; Physiology; Peripheral Vascular
   Disease
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Cardiovascular System & Cardiology; Physiology
GA 186KI
UT WOS:000247777200008
PM 17237245
DA 2025-06-11
ER

PT J
AU Cui, YL
   Qu, ZZ
   Li, LL
   Hu, WM
AF Cui, Yuliang
   Qu, Zhenzhen
   Li, Lingling
   Hu, Wenmei
TI Gender difference in the association between serum uric acid and
   metabolic dysfunction-associated steatotic liver disease in patients
   with newly diagnosed type 2 diabetes
SO BMC GASTROENTEROLOGY
LA English
DT Article
DE Type 2 diabetes; Serum uric acid; MASLD; Sex
ID FATTY-LIVER; HEPATIC STEATOSIS; MASLD; RISK; GENERATION; FIBROSIS;
   STRESS
AB PurposeTo investigate the relationship between serum uric acid (SUA) levels and metabolic dysfunction-associated steatotic liver disease (MASLD) in newly diagnosed type 2 diabetic patients.MethodsWe performed this retrospective research among 1087 inpatients with new-onset type 2 diabetes millitus (T2DM). Data were analyzed according to gender. Then, the populations were stratified according to their body mass index (BMI) levels in men and women, respectively. The physical and biochemical indicators were measured and recorded. The relationship between SUA and MASLD was estimated using logistic regression analysis, and the unadjusted and adjusted odds ratios (ORs) were calculated.ResultsAfter adjusting for age, BMI, and other components of the metabolic syndrome, SUA was independently associated with MASLD only in men, but not in women. In addition, for men, the SUA levels were independently associated with MASLD in both non-overweight/obesity and overweight/obesity group. However, for women, the SUA levels were independently related to MASLD in non-overweight/obesity group. There was no association between SUA and MASLD in women with overweight/obesity.ConclusionIn newly diagnosed type 2 diabetic patients, elevated SUA is an independent predictor for the risk of MASLD in males. In females, the relationship between SUA and MASLD may depend on BMI, with significance only in non-overweight/obese individuals.
C1 [Cui, Yuliang; Qu, Zhenzhen; Hu, Wenmei] Shandong Univ, Qilu Hosp, Dezhou Hosp, Dept Endocrinol, Dezhou 253000, Peoples R China.
   [Li, Lingling] Shandong Univ, Dept Hlth Management, Qilu Hosp, Dezhou Hosp, Dezhou 253000, Peoples R China.
C3 Shandong University; Shandong University
RP Hu, WM (corresponding author), Shandong Univ, Qilu Hosp, Dezhou Hosp, Dept Endocrinol, Dezhou 253000, Peoples R China.
EM dzhuwenmei@163.com
RI Cui, Yuliang/Y-9976-2018
FU Natural Science Foundation of Shandong Province
FX The authors would be grateful for language services by Duoease
   Scientific Service Center.
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PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-230X
J9 BMC GASTROENTEROL
JI BMC Gastroenterol.
PD APR 30
PY 2025
VL 25
IS 1
AR 322
DI 10.1186/s12876-025-03917-9
PG 10
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 2CY0G
UT WOS:001479676100003
PM 40307757
DA 2025-06-11
ER

PT J
AU Zhou, B
   Yuan, YX
   Shi, L
   Hu, S
   Wang, D
   Yang, Y
   Pan, YH
   Kong, DX
   Shikov, AN
   Duez, P
   Jin, M
   Li, XH
   Hu, XB
AF Zhou, Bo
   Yuan, Yaxia
   Shi, Le
   Hu, Sheng
   Wang, Dong
   Yang, Yang
   Pan, Yuanhu
   Kong, Dexin
   Shikov, Alexander N.
   Duez, Pierre
   Jin, Moonsoo
   Li, Xiaohua
   Hu, Xuebo
TI Creation of an Anti-Inflammatory, Leptin-Dependent Anti-Obesity
   Celastrol Mimic with Better Druggability
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Article
DE natural products; obesity; celastrol; Glycyrrhiza uralensis;
   glycyrrhetinic acid; inflammation; Tripterygium wilfordii
ID INSULIN-RESISTANCE; KAPPA-B; INFLAMMATION; OBESITY; MACROPHAGES;
   CONTRIBUTE; WITHAFERIN; STRESS; MICE
AB Obesity is characterized by an excessive body mass, but is also closely associated with metabolic syndrome. And, so far, only limited pharmacological treatments are available for obesity management. Celastrol, a pentacyclic triterpenoid from a traditional Chinese medicine (Tripterygium wilfordii Hook.f.), has shown remarkable potency against obesity, inflammation and cancer, but its high toxicity, low natural abundance and tedious chemical synthesis hindered its translation into clinics. In the present work, a triterpenoid library was screened for compounds with both high natural abundance and structural similarity to celastrol; from this library, glycyrrhetinic acid (GA), a compound present in extremely high yields in Glycyrrhiza uralensis Fisch. ex DC., was selected as a possible scaffold for a celastrol mimic active against obesity. A simple chemical modification of GA resulted in GA-02, a derivative that suppressed 68% of food intake in diet-induced obesity mice and led to 26.4% weight loss in 2 weeks. GA-02 plays a role in obesity treatment by re-activating leptin signaling and reducing systemic and, more importantly, hypothalamic inflammation. GA-02 was readily bioavailable with unnoticeable in vitro and in vivo toxicities. The strategy of scaffold search and modification on the basis of bio-content and structural similarity has proved to be a green, economic, efficient and practical way of widening the medicinal applications of "imperfect" bioactive natural compounds.
C1 [Zhou, Bo; Shi, Le; Yang, Yang; Li, Xiaohua; Hu, Xuebo] Huazhong Agr Univ, Coll Plant Sci & Technol, Lab Nat Med & Mol Engn, Wuhan, Peoples R China.
   [Yuan, Yaxia] Univ Florida, Coll Pharm, Dept Pharmacodynam, Gainesville, FL 32610 USA.
   [Hu, Sheng] Hubei Canc Hosp, Wuhan, Peoples R China.
   [Wang, Dong; Kong, Dexin] Huazhong Agr Univ, Coll Informat, Agr Bioinformat Key Lab Hubei Prov, Wuhan, Peoples R China.
   [Pan, Yuanhu] Huazhong Agr Univ, Natl Reference Lab Vet Drug Residues, Wuhan, Peoples R China.
   [Pan, Yuanhu] Huazhong Agr Univ, MAO Key Lab Detect Vetennary Drug Residues, Wuhan, Peoples R China.
   [Shikov, Alexander N.] St Petersburg State Chem Pharmaceut Univ, Dept Pharmaceut Formulat, St Petersburg, Russia.
   [Duez, Pierre] Univ Mons, Unit Therapeut Chem & Pharmacognosy, Mons, Belgium.
   [Jin, Moonsoo] Weill Cornell Med Coll, Dept Radiol, New York, NY USA.
C3 Huazhong Agricultural University; State University System of Florida;
   University of Florida; Huazhong Agricultural University; Huazhong
   Agricultural University; Huazhong Agricultural University; University of
   Mons; Cornell University; Weill Cornell Medicine
RP Hu, XB (corresponding author), Huazhong Agr Univ, Coll Plant Sci & Technol, Lab Nat Med & Mol Engn, Wuhan, Peoples R China.
EM xuebohu@mail.hzau.edu.cn
RI Yuan, Yaxia/N-6525-2014; hu, shengquan/S-8266-2019; Shi,
   Le/AAH-2754-2020; Shikov, Alexander/B-1804-2008; Kong,
   De-Xin/E-5630-2012; liu, yingchun/JNR-4688-2023
FU Hubei Technology Innovation Center for Agricultural Sciences
   [2020-620-000-002-04]; National Key R&D Program of China
   [2019YFE0108700]; Fundamental Research Funds for the Central
   Universities program [2662017PY110, 2662015CFA091]; National Science &
   Technology Fundamental Resources Investigation Program of China
   [2018FY100704]; National Science Foundation of China [81972308]
FX This research was supported by Hubei Technology Innovation Center for
   Agricultural Sciences-"2020 key technology research and demonstration
   project of safe and efficient production of genuine medicinal materials"
   (No. 2020-620-000-002-04), National Key R&D Program of China (No.
   2017YFD0501500) and the Fundamental Research Funds for the Central
   Universities program (Nos. 2662017PY110 and 2662015CFA091) to XH. The
   research was supported by National Science & Technology Fundamental
   Resources Investigation Program of China (No. 2018FY100704) and National
   Key R&D Program of China (No. 2019YFE0108700) to XL. The research was
   also supported by National Science Foundation of China (No. 81972308 to
   SH).
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NR 57
TC 9
Z9 10
U1 5
U2 44
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD AUG 30
PY 2021
VL 12
AR 705252
DI 10.3389/fphar.2021.705252
PG 17
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA UU2MF
UT WOS:000698634800001
PM 34526895
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Cano, R
   Pérez, JL
   Dávila, LA
   Ortega, A
   Gómez, Y
   Valero-Cedeño, NJ
   Parra, H
   Manzano, A
   Castro, TIV
   Albornoz, MPD
   Cano, G
   Rojas-Quintero, J
   Chacín, M
   Bermúdez, V
AF Cano, Raquel
   Perez, Jose L.
   Davila, Lisse Angarita
   Ortega, Angel
   Gomez, Yosselin
   Valero-Cedeno, Nereida Josefina
   Parra, Heliana
   Manzano, Alexander
   Veliz Castro, Teresa Isabel
   Albornoz, Maria P. Diaz
   Cano, Gabriel
   Rojas-Quintero, Joselyn
   Chacin, Maricarmen
   Bermudez, Valmore
TI Role of Endocrine-Disrupting Chemicals in the Pathogenesis of
   Non-Alcoholic Fatty Liver Disease: A Comprehensive Review
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE non-alcoholic fatty liver disease; endocrine-disrupting chemicals; liver
   disorder; environmental pollutants; exposure
ID PERSISTENT ORGANIC POLLUTANTS; BISPHENOL-A BPA; POLYCYCLIC
   AROMATIC-HYDROCARBONS; HEPATIC LIPID-ACCUMULATION; OXIDATIVE STRESS;
   INSULIN-RESISTANCE; MITOCHONDRIAL DYSFUNCTION; WAIST CIRCUMFERENCE;
   CHRONIC EXPOSURE; GENE-EXPRESSION
AB Non-alcoholic fatty liver disease (NAFLD) is considered the most common liver disorder, affecting around 25% of the population worldwide. It is a complex disease spectrum, closely linked with other conditions such as obesity, insulin resistance, type 2 diabetes mellitus, and metabolic syndrome, which may increase liver-related mortality. In light of this, numerous efforts have been carried out in recent years in order to clarify its pathogenesis and create new prevention strategies. Currently, the essential role of environmental pollutants in NAFLD development is recognized. Particularly, endocrine-disrupting chemicals (EDCs) have a notable influence. EDCs can be classified as natural (phytoestrogens, genistein, and coumestrol) or synthetic, and the latter ones can be further subdivided into industrial (dioxins, polychlorinated biphenyls, and alkylphenols), agricultural (pesticides, insecticides, herbicides, and fungicides), residential (phthalates, polybrominated biphenyls, and bisphenol A), and pharmaceutical (parabens). Several experimental models have proposed a mechanism involving this group of substances with the disruption of hepatic metabolism, which promotes NAFLD. These include an imbalance between lipid influx/efflux in the liver, mitochondrial dysfunction, liver inflammation, and epigenetic reprogramming. It can be concluded that exposure to EDCs might play a crucial role in NAFLD initiation and evolution. However, further investigations supporting these effects in humans are required.
C1 [Cano, Raquel; Perez, Jose L.; Ortega, Angel; Gomez, Yosselin; Parra, Heliana; Manzano, Alexander; Albornoz, Maria P. Diaz] Univ Zulia, Sch Med, Endocrine & Metab Dis Res Ctr, Maracaibo 4004, Venezuela.
   [Davila, Lisse Angarita] Univ Andres Bello, Fac Med, Escuela Nutr & Dietet, Sede Concepcion 4260000, Chile.
   [Valero-Cedeno, Nereida Josefina; Veliz Castro, Teresa Isabel] Univ Estatal Sur Manabi, Fac Ciencias Salud, Carrera Lab Clin, E482, Jipijapa, Ecuador.
   [Cano, Gabriel] Free Univ Berlin, Inst Pharm, Konigin Louise Strabe 2-4, D-14195 Berlin, Germany.
   [Rojas-Quintero, Joselyn] Harvard Med Sch, Brigham & Womens Hosp, Div Pulm & Crit Care Med, Boston, MA 02115 USA.
   [Chacin, Maricarmen; Bermudez, Valmore] Univ Simon Bolivar, Fac Ciencias Salud Barranquilla, Barranquilla 55132, Colombia.
C3 Universidad Andres Bello; Free University of Berlin; Harvard University;
   Harvard Medical School; Harvard University Medical Affiliates; Brigham &
   Women's Hospital
RP Bermúdez, V (corresponding author), Univ Simon Bolivar, Fac Ciencias Salud Barranquilla, Barranquilla 55132, Colombia.
EM raquelamiracano@gmail.com; joseluispv2811@gmail.com;
   lisse.angarita@unab.cl; angelort94@hotmail.com;
   yoselin_gomezgil@hotmail.com; nereida.valero@unesum.edu.ec;
   helianapp20@hotmail.com; amanzano_8@hotmail.com;
   teresa.veliz@unesum.edu.ec; mariadiazalbornoz@hotmail.com;
   gabriel.simon.cano@fu-berlin.de; jrojasquintero@bwh.harvard.edu;
   m.chacin@unisimonbolivar.edu.co; v.bermudez@unisimonbolivar.edu.co
RI Ortega, Angel/JAO-1213-2023; Bermudez, Valmore/E-3517-2018
OI Cano, Gabriel/0000-0003-2874-5330; Parra, Heliana/0000-0002-6604-4212;
   Manzano, Alexander/0000-0001-6652-8834; Perez Vicuna, Jose
   Luis/0000-0003-0914-5858; Chacin, Maricarmen/0000-0002-5208-9401;
   Ortega-Martinez, Angel/0000-0002-7180-4765; Gomez,
   Yosselin/0000-0003-2146-4560; Bermudez, Valmore/0000-0003-1880-8887;
   Rojas-Quintero, Joselyn Joanna/0000-0003-4994-075X; Angarita,
   Lisse/0000-0001-7860-5112
FU Consejo de Desarrollo Cientifico, Humanistico y Tecnologico (CONDES),
   University of Zulia [CC-0437-10-21-09-10]; Fundacite-Zulia
   [FZ-0058-2007]
FX This work was supported by research grant no. CC-0437-10-21-09-10 from
   Consejo de Desarrollo Cientifico, Humanistico y Tecnologico (CONDES),
   University of Zulia, and research grant no. FZ-0058-2007 from
   Fundacite-Zulia.
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NR 196
TC 68
Z9 73
U1 6
U2 60
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD MAY
PY 2021
VL 22
IS 9
AR 4807
DI 10.3390/ijms22094807
PG 22
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA SC0OV
UT WOS:000650383100001
PM 34062716
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Meza-Torres, C
   Hernández-Camacho, JD
   Cortés-Rodríguez, AB
   Fang, L
   Bui Thanh, T
   Rodríguez-Bies, E
   Navas, P
   López-Lluch, G
AF Meza-Torres, Catherine
   Diego Hernandez-Camacho, Juan
   Belen Cortes-Rodriguez, Ana
   Fang, Luis
   Tung Bui Thanh
   Rodriguez-Bies, Elisabet
   Navas, Placido
   Lopez-Lluch, Guillermo
TI Resveratrol Regulates the Expression of Genes Involved in CoQ Synthesis
   in Liver in Mice Fed with High Fat Diet
SO ANTIOXIDANTS
LA English
DT Article
DE resveratrol; coenzyme Q; liver; antioxidant; mitochondria; high-fat diet
ID MEMBRANE REDOX SYSTEM; COENZYME-Q; OXIDATIVE STRESS; MOUSE-LIVER;
   MITOCHONDRIAL-FUNCTION; MITOFUSIN 2; HUMAN-CELLS; VITAMIN-E;
   RESTRICTION; UBIQUINONE
AB Resveratrol (RSV) is a bioactive natural molecule that induces antioxidant activity and increases protection against oxidative damage. RSV could be used to mitigate damages associated to metabolic diseases and aging. Particularly, RSV regulates different aspects of mitochondrial metabolism. However, no information is available about the effects of RSV on Coenzyme Q (CoQ), a central component in the mitochondrial electron transport chain. Here, we report for the first time that RSV modulates COQ genes and parameters associated to metabolic syndrome in mice. Mice fed with high fat diet (HFD) presented a higher weight gain, triglycerides (TGs) and cholesterol levels while RSV reverted TGs to control level but not weight or cholesterol. HFD induced a decrease of COQs gene mRNA level, whereas RSV reversed this decrease in most of the COQs genes. However, RSV did not show effect on CoQ(9), CoQ(10) and total CoQ levels, neither in CoQ-dependent antioxidant enzymes. HFD influenced mitochondrial dynamics and mitophagy markers. RSV modulated the levels of PINK1 and PARKIN and their ratio, indicating modulation of mitophagy. In summary, we report that RSV influences some of the metabolic adaptations of HFD affecting mitochondrial physiology while also regulates COQs gene expression levels in a process that can be associated with mitochondrial dynamics and turnover.
C1 [Meza-Torres, Catherine; Diego Hernandez-Camacho, Juan; Belen Cortes-Rodriguez, Ana; Tung Bui Thanh; Rodriguez-Bies, Elisabet; Navas, Placido; Lopez-Lluch, Guillermo] Univ Pablo Olavide, Ctr Andaluz Biol Desarrollo, CSIC JA, Seville 41013, Spain.
   [Meza-Torres, Catherine; Diego Hernandez-Camacho, Juan; Belen Cortes-Rodriguez, Ana; Tung Bui Thanh; Rodriguez-Bies, Elisabet; Navas, Placido; Lopez-Lluch, Guillermo] Inst Salud Carlos III, CIBERER, Seville 41013, Spain.
   [Fang, Luis] Univ Norte, Immunol & Mol Biol Grp, Barranquilla 081007, Colombia.
   [Tung Bui Thanh] Vietnam Natl Univ, Sch Med & Pharm, Hanoi 100000, Vietnam.
   [Rodriguez-Bies, Elisabet] Univ Pablo Olavide, Dept Deporte & Informat, Seville 41013, Spain.
C3 Consejo Superior de Investigaciones Cientificas (CSIC); Universidad
   Pablo de Olavide; CSIC - Andalusian Center for Developmental Biology
   (CABD); Instituto de Salud Carlos III; CIBER - Centro de Investigacion
   Biomedica en Red; CIBERER; Universidad del Norte Colombia; Vietnam
   National University Hanoi (VNU Hanoi) System; Universidad Pablo de
   Olavide
RP López-Lluch, G (corresponding author), Univ Pablo Olavide, Ctr Andaluz Biol Desarrollo, CSIC JA, Seville 41013, Spain.; López-Lluch, G (corresponding author), Inst Salud Carlos III, CIBERER, Seville 41013, Spain.
EM mezacathemeza@gmail.com; jdhercam@upo.es; abcorrod@upo.es;
   lfang@uninorte.edu.co; tungasia82@yahoo.es; ecrodbie1@upo.es;
   pnavas@upo.es; glopllu@upo.es
RI NAVAS, PLACIDO/R-5943-2019; Fang, Luis/AAF-7562-2019; Lopez-Lluch,
   Guillermo/N-4742-2014; Rodriguez-Bies, Elisabet/A-4459-2016
OI Fang, Luis/0000-0002-4986-6118; Lopez-Lluch,
   Guillermo/0000-0001-9830-8502; Navas, Placido/0000-0002-4115-7966;
   Rodriguez-Bies, Elisabet/0000-0002-5910-2920
FU Spanish Ministry of Education, Culture and Sports [FPU16/03264]
FX J.D.H.C. is a predoctoral research fellow from the Spanish Ministry of
   Education, Culture and Sports [FPU16/03264].
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TC 12
Z9 12
U1 1
U2 9
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD MAY
PY 2020
VL 9
IS 5
AR 431
DI 10.3390/antiox9050431
PG 17
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA LW6WJ
UT WOS:000539284200074
PM 32429295
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Pleskacova, A
   Bartakova, V
   Chalasova, K
   Pacal, L
   Kankova, K
   Tomandl, J
AF Pleskacova, Anna
   Bartakova, Vendula
   Chalasova, Katarina
   Pacal, Lukas
   Kankova, Katerina
   Tomandl, Josef
TI Uric Acid and Xanthine Levels in Pregnancy Complicated by Gestational
   Diabetes MellitusThe Effect on Adverse Pregnancy Outcomes
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE uric acid; uricemia; xanthine; gestational diabetes mellitus; pregnancy;
   adverse perinatal outcomes
ID METABOLIC SYNDROME; URATE TRANSPORTER; OXIDATIVE STRESS; SERUM; WOMEN;
   RISK; ASSOCIATION; POPULATION; REGULATOR; OBESITY
AB Uric acid (UA) levels are associated with many diseases including those related to lifestyle. The aim of this study was to evaluate the influence of clinical and anthropometric parameters on UA and xanthine (X) levels during pregnancy and postpartum in women with physiological pregnancy and pregnancy complicated by gestational diabetes mellitus (GDM), and to evaluate their impact on adverse perinatal outcomes. A total of 143 participants were included. Analyte levels were determined by HPLC with ultraviolet detection (HPLC-UV). Several single-nucleotide polymorphisms (SNPs) in UA transporters were genotyped using commercial assays. UA levels were higher within GDM women with pre-gestational obesity, those in high-risk groups, and those who required insulin during pregnancy. X levels were higher in the GDM group during pregnancy and also postpartum. Positive correlations between UA and X levels with body mass index (BMI) and glycemia levels were found. Gestational age at delivery was negatively correlated with UA and X levels postpartum. Postpartum X levels were significantly higher in women who underwent caesarean sections. Our data support a possible link between increased UA levels and a high-risk GDM subtype. UA levels were higher among women whose glucose tolerance was severely disturbed. Mid-gestational UA and X levels were not linked to adverse perinatal outcomes.
C1 [Pleskacova, Anna; Bartakova, Vendula; Chalasova, Katarina; Pacal, Lukas; Kankova, Katerina; Tomandl, Josef] Masaryk Univ, Dept Pathophysiol, Fac Med, Brno 62500, Czech Republic.
   [Pleskacova, Anna; Tomandl, Josef] Masaryk Univ, Dept Biochem, Fac Med, Brno 62500, Czech Republic.
C3 Masaryk University Brno; Masaryk University Brno
RP Tomandl, J (corresponding author), Masaryk Univ, Dept Pathophysiol, Fac Med, Brno 62500, Czech Republic.; Tomandl, J (corresponding author), Masaryk Univ, Dept Biochem, Fac Med, Brno 62500, Czech Republic.
EM pleskacova@med.muni.cz; vbartak@med.muni.cz;
   katarina.kuricova@gmail.com; paci@med.muni.cz; kankov@med.muni.cz;
   tomandl@med.muni.cz
RI Bartáková, Vendula/GSI-4263-2022; Chalásová, Katarína/ABA-6857-2021;
   Tomandl, Josef/B-7492-2009; Pacal, Lukas/G-8060-2012
OI Chalasova, Katarina/0000-0003-4796-5152; Pleskacova,
   Anna/0000-0002-5727-5676; Tomandl, Josef/0000-0001-6554-3733; Bartakova,
   Vendula/0000-0002-5047-4752; Kankova, Katerina/0000-0001-9548-0630;
   Kankova, Katerina/0000-0002-5574-1768; Pacal, Lukas/0000-0003-1118-7424
FU Ministry of Health of the Czech Republic [16-28040A]
FX This work was supported by the Ministry of Health of the Czech Republic,
   grant number 16-28040A.
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NR 59
TC 16
Z9 19
U1 1
U2 12
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD NOV
PY 2018
VL 19
IS 11
AR 3696
DI 10.3390/ijms19113696
PG 13
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA HC0ZM
UT WOS:000451528500411
PM 30469427
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Kong, M
   Liu, CQ
   Guo, YF
   Gao, Q
   Zhong, CR
   Zhou, XZ
   Chen, RJ
   Xiong, GP
   Yang, XF
   Hao, LP
   Yang, NH
AF Kong, Man
   Liu, Chaoqun
   Guo, Yanfang
   Gao, Qing
   Zhong, Chunrong
   Zhou, Xuezhen
   Chen, Renjuan
   Xiong, Guoping
   Yang, Xuefeng
   Hao, Liping
   Yang, Nianhong
TI Higher level of GGT during mid-pregnancy is associated with increased
   risk of gestational diabetes mellitus
SO CLINICAL ENDOCRINOLOGY
LA English
DT Article
DE mid-pregnancy; gestational diabetes mellitus; liver enzymes;
   gamma-glutamyl transferase (GGT)
ID GAMMA-GLUTAMYL-TRANSFERASE; C-REACTIVE PROTEIN; LIVER-ENZYMES; METABOLIC
   SYNDROME; OXIDATIVE STRESS; INSULIN-RESISTANCE; HYPERGLYCEMIA; WOMEN;
   MEN
AB Objective: This study was to explore the link between gamma-glutamyl transferase (GGT), alanine transaminase (ALT) and aspartate transaminase (AST) levels during early-middle pregnancy and subsequent risk of gestational diabetes mellitus (GDM).
   Methods: In a prospective cohort study, pregnant women enrolled prior to 16 weeks of gestation were followed up until delivery. GGT, AST and ALT levels were tested during weeks 14-18 of gestation and oral glucose tolerance test was conducted during 24-28weeks to screen GDM.
   Results: The GDM rate was 8.1% (122/1512). Mean GGT level was higher in GDM than non-GDM women (18.7 +/- 13.0 vs 14.5 +/- 7.0, P<.001). The higher GGT level was 26.9 similar to 74.0 U/L, which was significantly associated with increased risk of GDM. The adjusted RR (95% CI) comparing higher GGT level versus lower was 5.40 (3.36-8.68). No significant correlation was found between ALT or AST levels and the risk of GDM.
   Conclusions: The results suggest that pregnant women with higher serum GGT during early-middle pregnancy have higher risk of developing GDM. A GGT level >26.9 U/L may indicate an increased risk of developing GDM later and should be further concerned.
C1 [Kong, Man] Huazhong Univ Sci & Technol, Tongji Med Coll, Cent Hosp Wuhan, Dept Med Lab, Wuhan, Hubei, Peoples R China.
   [Liu, Chaoqun; Guo, Yanfang; Gao, Qing; Zhong, Chunrong; Zhou, Xuezhen; Chen, Renjuan; Yang, Xuefeng; Hao, Liping; Yang, Nianhong] Huazhong Univ Sci & Technol, MOE Key Lab Environm & Hlth, Hubei Key Lab Food Nutr & Safety, Sch Publ Hlth,Tongji Med Coll,Dept Nutr & Food Hy, Wuhan, Hubei, Peoples R China.
   [Xiong, Guoping] Huazhong Univ Sci & Technol, Tongji Med Coll, Cent Hosp Wuhan, Dept Obstet, Wuhan, Hubei, Peoples R China.
C3 Huazhong University of Science & Technology; Huazhong University of
   Science & Technology; Huazhong University of Science & Technology
RP Yang, NH (corresponding author), Huazhong Univ Sci & Technol, MOE Key Lab Environm & Hlth, Hubei Key Lab Food Nutr & Safety, Sch Publ Hlth,Tongji Med Coll,Dept Nutr & Food Hy, Wuhan, Hubei, Peoples R China.
EM zynh@mails.tjmu.edu.cn
RI gao, qing/LDG-6497-2024; Xiong, Guoping/H-9553-2014; Yang,
   Nianhong/IQS-4379-2023
OI kong, man/0000-0002-9960-1556
FU National Program on Basic Research Project of China [2013FY114200]
FX National Program on Basic Research Project of China, Grant/Award Number:
   2013FY114200 for Nianhong Yang
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NR 31
TC 15
Z9 15
U1 0
U2 17
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0300-0664
EI 1365-2265
J9 CLIN ENDOCRINOL
JI Clin. Endocrinol.
PD MAY
PY 2018
VL 88
IS 5
BP 700
EP 705
DI 10.1111/cen.13558
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA GD0DR
UT WOS:000430170300012
PM 29385633
DA 2025-06-11
ER

PT J
AU Castiglione, RC
   Barros, CMMR
   Boa, BCS
   De Souza, MDC
   Bouskela, E
AF Castiglione, Raquel Carvalho
   Barros, Carlos M. M. R.
   Boa, Beatriz C. S.
   De Souza, Maria das Gracas C.
   Bouskela, Eliete
TI Effects of Selenium in the Microcirculation of Fructose-Fed Hamsters
SO JOURNAL OF VASCULAR RESEARCH
LA English
DT Article
DE Microcirculation; Selenium; Fructose; Cheek pouch preparation;
   Endothelial dysfunction
ID ENDOTHELIUM-DEPENDENT RELAXATION; DIABETES-MELLITUS;
   CARDIOVASCULAR-DISEASES; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   OXIDATIVE STRESS; CHEEK POUCH; ATHEROSCLEROSIS; SUPPLEMENTATION;
   HYPERGLYCEMIA
AB Background and Aims: Fructose intake is directly related to vascular dysfunction and it is a risk factor for the development of metabolic and cardiovascular diseases, such as obesity, diabetes, and hypertension. Selenium, a component of antioxidant enzymes, improves hyperglycemia and vascular function in diabetic animals. The aim of this study was to evaluate the effects of dietary selenium supplementation on microcirculatory and metabolic parameters of fructose-fed hamsters. Methods and Results: Male hamsters (Mesocricetus auratus) had their drinking water substituted or not by 10% fructose solution for 60 days, during which their microcirculatory function was evaluated in the cheek pouch preparation. Blood glucose and serum insulin levels were also tested. Microcirculatory responses to acetylcholine (an endothelium-dependent vasodilator) and to sodium nitroprusside (SNP, an endothelium-independent vasodilator), and macromolecular permeability increase induced by a 30-min ischemia/reperfusion (I/R) procedure, showed that endothelium-dependent and independent vasodilatation was significantly increased in animals that had high selenium supplementation, in both the control and fructose-fed groups. Selenium supplementation protected against plasma leakage induced by I/R in all control and fructose-fed groups. Conclusion: Our results indicate that dietary selenium supplementation reduces microvascular dysfunction by increasing endothelial-dependent and independent dilatation and reducing macromolecular permeability increase in fructose-fed animals. (c) 2018 S. Karger AG, Basel
C1 [Castiglione, Raquel Carvalho; Barros, Carlos M. M. R.; Boa, Beatriz C. S.; De Souza, Maria das Gracas C.; Bouskela, Eliete] Univ Estado Rio De Janeiro, Biomed Ctr, Lab Clin & Expt Res Vasc Biol BioVasc, Rio De Janeiro, Brazil.
C3 Universidade do Estado do Rio de Janeiro
RP Castiglione, RC (corresponding author), Rua Sao Francisco Xavier 524, BR-20550013 Rio De Janeiro, RJ, Brazil.
EM rccastiglione@gmail.com
RI Castiglione, Raquel/K-3969-2013
FU Brazilian National Council for Scientific and Technologic Development
   (CNPq) [474116/20085]; Carlos Chagas Filho Foundation for Research
   Support in the State of Rio de Janeiro (FAPERJ) [E-26/111.732/2011]
FX This work was supported by the Brazilian National Council for Scientific
   and Technologic Development (CNPq; grant No. 474116/20085) and Carlos
   Chagas Filho Foundation for Research Support in the State of Rio de
   Janeiro (FAPERJ; grant No. E-26/111.732/2011).
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NR 37
TC 1
Z9 1
U1 0
U2 4
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1018-1172
EI 1423-0135
J9 J VASC RES
JI J. Vasc. Res.
PY 2018
VL 55
IS 4
BP 203
EP 209
DI 10.1159/000489957
PG 7
WC Physiology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology; Cardiovascular System & Cardiology
GA GW8UU
UT WOS:000447257300002
PM 30001541
DA 2025-06-11
ER

PT J
AU Mendes, KL
   Lelis, DD
   Santos, SHS
AF Mendes, Keila Lopes
   Lelis, Deborah de Farias
   Sousa Santos, Sergio Henrique
TI Nuclear sirtuins and inflammatory signaling pathways
SO CYTOKINE & GROWTH FACTOR REVIEWS
LA English
DT Review
DE Inflammation; Sirtuins; Sirtuin 1; Sirtuin 2; NF-kappa beta
ID NF-KAPPA-B; DEPENDENT GENE-EXPRESSION; PROMOTES CELL-SURVIVAL;
   MITOCHONDRIAL SIRTUINS; OXIDATIVE STRESS; EMERGING ROLES;
   ADIPOSE-TISSUE; TRANSCRIPTIONAL ACTIVITY; ENERGY-EXPENDITURE; MAMMALIAN
   SIRTUINS
AB The regulation of chronic inflammation has received considerable research attention in recent years because of its contribution to the pathogenesis of chronic diseases such as arthritis, diabetes, metabolic syndrome and obesity. Thus, strategies that inhibit the inflammatory state may be beneficial in improving the pathophysiology of several inflammation-related disorders. Sirtuins are a family of histone deacetylases that contain seven enzymatic activities in mammals (SIRT1-SIRT7) and function to suppress gene transcription by epigenetic mechanisms. Nuclear sirtuins (SIRT 1, 2, 6 and 7) in particular may play an important role in the regulation of inflammatory responses. In the present review, we assessed the roles of nuclear sirtuins in inflammatory reactions: SIRT1 has been shown to suppress NF-kappa b activity, the master regulator of cellular inflammatory response, decrease COX-2 and iNOS production, and increase antioxidant gene expression that suppressed inflammation. SIRT2 activity included the deacetylation of p65 subunit of NF-kappa beta and RIP-1, while SIRT6 has been shown to interact with p65/RelA bound to the NF-kappa beta promoter region and repress transcriptional activity. Furthermore, recent studies have shown that the absence of SIRT7 produced an increase in inflammation, illustrating that SIRT7 also functioned to decrease inflammation. Given their significant roles in the regulation of chronic inflammation, nuclear sirtuins represent potential therapeutic targets in the control of chronic inflammatory diseases.
C1 [Mendes, Keila Lopes; Sousa Santos, Sergio Henrique] Univ Estadual Montes Claros Unimontes, Postgrad Program Hlth Sci, Lab Hlth Sci, Montes Claros, MG, Brazil.
   [Mendes, Keila Lopes] IFMG, Ouro Preto, MG, Brazil.
   [Lelis, Deborah de Farias] Univ Estadual Montes Claros Unimontes, Biol, Montes Claros, MG, Brazil.
   [Sousa Santos, Sergio Henrique] Univ Fed Minas Gerais, Food Engn Dept, Inst Agr Sci ICA, Montes Claros, MG, Brazil.
C3 Universidade Estadual de Montes Claros; Instituto Federal de Educacao,
   Ciencia e Tecnologia de Minas Gerais (IFMG); Universidade Estadual de
   Montes Claros; Universidade Federal de Minas Gerais
RP Santos, SHS (corresponding author), Univ Estadual Montes Claros, Dept Hlth Sci, Hosp Univ Clemente Faria, Ave Cula Mangabeira 562, BR-39401001 Montes Claros, MG, Brazil.
EM sergiosousas@hotmail.com
RI Santos, Sérgio/D-8143-2011
OI Santos, Sergio/0000-0002-7788-5447
FU FAPEMIG; CAPES; CNPq
FX The present study was supported by grants from FAPEMIG, CAPES, and CNPq.
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NR 108
TC 191
Z9 210
U1 1
U2 48
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1359-6101
EI 1879-0305
J9 CYTOKINE GROWTH F R
JI Cytokine Growth Factor Rev.
PD DEC
PY 2017
VL 38
BP 98
EP 105
DI 10.1016/j.cytogfr.2017.11.001
PG 8
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA FO1OM
UT WOS:000416532200010
PM 29132743
DA 2025-06-11
ER

PT J
AU Tejada, S
   Pinya, S
   Bibiloni, MD
   Tur, JA
   Pons, A
   Sureda, A
AF Tejada, Silvia
   Pinya, Samuel
   Bibiloni, Maria del Mar
   Tur, Josep A.
   Pons, Antoni
   Sureda, Antoni
TI Cardioprotective Effects of the Polyphenol Hydroxytyrosol from Olive Oil
SO CURRENT DRUG TARGETS
LA English
DT Review
DE Olea europaea; olive oil; cardiovascular disease; polyphenols;
   atherosclerosis; antioxidant
ID VASCULAR ENDOTHELIAL-CELLS; LOW-DENSITY-LIPOPROTEIN; RANDOMIZED
   CONTROLLED-TRIAL; PHENOLIC-COMPOUNDS; OXIDATIVE STRESS; MEDITERRANEAN
   DIET; SIGNALING PATHWAYS; HUMAN ERYTHROCYTES; METABOLIC SYNDROME; HO-1
   EXPRESSION
AB Background: The Mediterranean diet includes olive oil as its primary source of fat. This diet is frequently associated to longevity and a lower incidence of chronic diseases due to its biological activities and health effects. Apart from oleic acid, olive oil contains many bioactive components including polyphenols that have been reported to exert antioxidant and anti-inflammatory activities. Polyphenols may almost in part be responsible for the protective effects against cardiovascular diseases associated with olive oil.
   Objective: To review and discuss the available literature on hydroxytyrosol effects as a cardioprotective agent. Moreover, we also discuss the chemistry, nutritional aspects and bioavailability of hydroxytyrosol.
   Results: Hydroxytyrosol is one of the major phenolic compounds in olive oil and has demonstrated strong radical-scavenging properties. Several studies have been performed in order to look further into the effects of the polyphenol hydroxytyrosol in relation to cardiovascular events and illnesses in animal trials and in vitro. However, no clinical trials have focused on the specific action of hydroxytyrosol and cardiovascular diseases, although some are being undertaken to look at olive oil or olive leaf extract properties.
   Conclusion: Hydroxytyrosol from olive oil exerts antioxidant, anti-inflammatory, anti-platelet aggregation and ati-atherogenic activities in in vitro and animal models. However, its possible therapeutic use in humans requires additional clinical trials.
C1 [Tejada, Silvia] Son Llatzer Hosp, IUNICS, Expt Lab, Res Unit, Ctra Manacor Km 4, E-07198 Palma De Mallorca, Balearic Island, Spain.
   [Pinya, Samuel] Univ Balearic Isl, Biol Dept, Grp Interdisciplinary Ecol EI, E-07122 Palma De Mallorca, Spain.
   [Bibiloni, Maria del Mar; Tur, Josep A.; Pons, Antoni; Sureda, Antoni] Univ Balearic Isl, Res Grp Community Nutr & Oxidat Stress NUCOX, E-07122 Palma De Mallorca, Balearic Island, Spain.
   [Bibiloni, Maria del Mar; Tur, Josep A.; Pons, Antoni; Sureda, Antoni] CIBEROBN Physiopathol Obes & Nutr, E-07122 Palma De Mallorca, Balearic Island, Spain.
C3 Universitat de les Illes Balears; IUNICS; Hospital Universitari Son
   Llatzer; Universitat de les Illes Balears; Universitat de les Illes
   Balears; CIBER - Centro de Investigacion Biomedica en Red; CIBEROBN
RP Sureda, A (corresponding author), Univ Balearic Isl, Res Grp Nutr & Oxidat Stress, Guillem Colom Bldg, E-07122 Palma De Mallorca, Balearic Island, Spain.
EM tosugo@hotmail.com
RI Tur, Josep/AAE-5748-2020; Tejada, Silvia/L-7297-2014; del Mar Bibiloni,
   Maria/M-3123-2014; Sureda, Antoni/N-9588-2019; Pinya,
   Samuel/AAB-2414-2021; Pons, Antoni/L-4844-2014
OI Pons, Antoni/0000-0003-2447-3868; Bibiloni Esteva, Maria del
   Mar/0000-0001-8926-9206; , Antoni/0000-0001-8656-6838; Pinya Fernandez,
   Samuel/0000-0001-5872-5440
FU Programme of Promotion of Biomedical Research and Health Sciences
   [CIBEROBN CB12/03/30038]
FX This work is funded by Programme of Promotion of Biomedical Research and
   Health Sciences, Project CIBEROBN CB12/03/30038.
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NR 100
TC 63
Z9 63
U1 4
U2 45
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1389-4501
EI 1873-5592
J9 CURR DRUG TARGETS
JI Curr. Drug Targets
PY 2017
VL 18
IS 13
BP 1477
EP 1486
DI 10.2174/1389450117666161005150650
PG 10
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA FI2AH
UT WOS:000411738100003
PM 27719659
DA 2025-06-11
ER

PT J
AU Dajani, A
   AbuHammour, A
AF Dajani, Asad
   AbuHammour, Adnan
TI Treatment of nonalcoholic fatty liver disease: Where do we stand an
   overview
SO SAUDI JOURNAL OF GASTROENTEROLOGY
LA English
DT Review
DE Insulin sensitizers; liver protectors; Nonalcoholic fatty liver disease
   and nonalcoholic steatohepatitis; Ursodeoxycholic acid; vitamin E
ID PLACEBO-CONTROLLED TRIAL; SHI-KO YHK; VITAMIN-E; INSULIN-RESISTANCE;
   METABOLIC SYNDROME; URSODEOXYCHOLIC ACID; AMERICAN ASSOCIATION;
   STEATOHEPATITIS NASH; COMBINATION THERAPY; LIPID-ACCUMULATION
AB Nonalcoholic fatty liver disease (NAFLD) is currently the most common liver disease worldwide, the prevalence of which had progressively increased over the past 10 years where other liver diseases remained at the same prevalence rates or are expected to decrease as in the case of hepatitis C virus (HCV). The treatment of NAFLD is of prime concern to health care professionals and patients due to the significant mortality and morbidity it implies; the problem is further escalated by the fact that standard of care medications targeting NAFLD remain experimental and without evidence base. Treatment nowadays is focused on lifestyle modification and managing the comorbid associated diseases, with a possible role for some hepatic protective agents. This review presents all the medications that had been proposed and used for the treatment of NAFLD with or without scientific rationale and includes agents for weight loss, insulin sensitizers, drugs that reduce blood lipids, glucagon-mimetics, drugs that may reduce fibrosis, angiotensin receptor blockers, and medicines believed to reduce endoplasmic reticular stress such as vitamin E, ursodeoxycholic acid, and S-adenosyl methionine. A quick review of the newer agents that proved to be promising such as obeticholic acid and GFT505 and the medicines that are still in the pipeline is also presented.
C1 [Dajani, Asad] Asad Dajani Specialized Ctr, Dept Gastroenterol & Hepatol, POB 6328, Sharjah, U Arab Emirates.
   [AbuHammour, Adnan] Abuhammour Med Ctr, Dept Gastroenterol & Hepatol, Dubai, U Arab Emirates.
RP Dajani, A (corresponding author), Asad Dajani Specialized Ctr, Dept Gastroenterol & Hepatol, POB 6328, Sharjah, U Arab Emirates.
EM aidajani@emirates.net.ae
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NR 131
TC 28
Z9 31
U1 0
U2 8
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, 400059, INDIA
SN 1319-3767
EI 1998-4049
J9 SAUDI J GASTROENTERO
JI Saudi J. Gastroenterol.
PD MAR-APR
PY 2016
VL 22
IS 2
BP 91
EP 105
DI 10.4103/1319-3767.178527
PG 15
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA DH5LY
UT WOS:000372832000002
PM 26997214
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Kang, SJ
   Lee, C
   Kruzliak, P
AF Kang, Seung Joo
   Lee, Changhyun
   Kruzliak, Peter
TI Effects of serum bilirubin on atherosclerotic processes
SO ANNALS OF MEDICINE
LA English
DT Review
DE Atherosclerosis; bilirubin; cardiovascular disease
ID CORONARY-ARTERY-DISEASE; ENDOTHELIAL ADHESION MOLECULES; HEME
   OXYGENASE-1 PROTECTS; MUSCLE-CELL PROLIFERATION; ISCHEMIC-HEART-DISEASE;
   INTIMA-MEDIA THICKNESS; C-REACTIVE PROTEIN; OXIDATIVE STRESS;
   CARBON-MONOXIDE; UGT1A1-ASTERISK-28 ALLELE
AB This review highlights the protective roles of bilirubin against the atherosclerotic process. Bilirubin belongs to the superfamily of tetrapyrrolic compounds formed during heme catabolism. Although for decades bilirubin was considered to be a harmful waste product, recent epidemiologic studies have shown that serum bilirubin levels have consistently been inversely associated with cardiovascular disease (CVD), as well as cardiovascular risk factors such as metabolic syndrome and diabetes. These clinical studies are supported by in vitro and in vivo experimental data and have demonstrated that bilirubin not only has an ability to scavenge overproduced reactive oxygen species and inhibit vascular smooth muscle cell proliferation but, additionally, has anti-inflammatory effects. In this review, we will discuss the inverse association of serum bilirubin and CVD and cardiovascular risk factors established in various clinical studies. We also review detailed experimental studies about the effect of bilirubin on atherosclerotic processes. In vitro, animal and human studies have proved that bilirubin inhibits oxidation of cholesterol which is an important step of atherosclerosis. Bilirubin attenuates chemotactic activity of monocytes and strongly inhibits adhesion of leukocytes to venule and production of pro-inflammatory cytokines. Bilirubin has inhibited serum-driven smooth muscle cell cycle progression at the G1 phase. Lastly, we will discuss briefly the influence of bilirubin on lipoprotein composition and endothelial dysfunction.
C1 [Kang, Seung Joo; Lee, Changhyun] Seoul Natl Univ, Hosp Healthcare Syst Gangnam Ctr, Inst Healthcare Res, Dept Internal Med, Seoul, South Korea.
   [Kruzliak, Peter] St Annes Univ Hosp, Int Clin Res Ctr, Dept Cardiovasc Dis, Brno 65691, Czech Republic.
   [Kruzliak, Peter] Masaryk Univ, Brno 65691, Czech Republic.
C3 Seoul National University (SNU); St. Anne's University Hospital Brno
   (FNUSA); St. Anne's University Hospital Brno (FNUSA-ICRC); Masaryk
   University Brno
RP Kruzliak, P (corresponding author), St Annes Univ Hosp, Int Clin Res Ctr, Dept Cardiovasc Dis, Pekarska 53, Brno 65691, Czech Republic.
EM peter.kruzliak@savba.sk
OI Lee, Changhyun/0000-0002-5839-6576
FU European Regional Development Fund-Project FNU-SA-ICRC [CZ.
   1.05/1.1.00/02.0123]
FX This study was elaborated within the grant of European Regional
   Development Fund-Project FNU-SA-ICRC (No. CZ. 1.05/1.1.00/02.0123). The
   authors report no conflicts of interest.
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NR 82
TC 47
Z9 52
U1 0
U2 17
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0785-3890
EI 1365-2060
J9 ANN MED
JI Ann. Med.
PD MAY
PY 2014
VL 46
IS 3
BP 138
EP 147
DI 10.3109/07853890.2014.895588
PG 10
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA AG7FP
UT WOS:000335584000005
PM 24720602
DA 2025-06-11
ER

PT J
AU Musso, G
   Gambino, R
   Cassader, M
AF Musso, G.
   Gambino, R.
   Cassader, M.
TI Non-alcoholic fatty liver disease from pathogenesis to management: an
   update
SO OBESITY REVIEWS
LA English
DT Article
DE Management; NAFLD; NASH; treatment
ID PLACEBO-CONTROLLED TRIAL; SERUM ALANINE AMINOTRANSFERASE; RANDOMIZED
   CONTROLLED-TRIAL; IMPROVES HEPATIC STEATOSIS; TYPE-2 DIABETIC-PATIENTS;
   OBSTRUCTIVE SLEEP-APNEA; LIFE-STYLE INTERVENTION; POPULATION-BASED
   COHORT; TERM-FOLLOW-UP; INSULIN-RESISTANCE
AB P>Non-alcoholic fatty liver disease (NAFLD), the most common chronic liver disease in the Western world, is tightly associated with obesity and metabolic syndrome. NAFLD entails an increased cardiometabolic and liver-related risk, the latter regarding almost exclusively non-alcoholic steatohepatitis (NASH), the progressive form of NAFLD. Pathogenetic models encompass altered hepatic lipid partitioning and adipokine action, increased oxidative stress, free fatty acid lipotoxicity. On this basis, lifestyle-, drug- or surgically induced weight loss, insulin sensitizers, antioxidants, lipid-lowering drugs have been evaluated in NAFLD/NASH. Most trials are small, of short duration, nonrandomized, without histological end points, thus limiting assessment of long-term safety and efficacy of proposed treatments.
   All NAFLD patients should be evaluated for their metabolic, cardiovascular and liver-related risk. Liver biopsy remains the gold standard for staging NAFLD, but non-invasive methods are under intense development. Weight loss through lifestyle intervention is the initial approach, because of established efficacy on NAFLD-associated cardiometabolic abnormalities, and to emerging benefits on necroinflammation and overall disease activity in NASH. Bariatric surgery warrants further evaluation before it can be routinely considered in morbidly obese NASH.
   Larger- and longer-duration randomized trials assessing safety and benefits of drugs on patient-oriented outcomes are needed before pharmacological treatment can be routinely recommended for NASH.
C1 [Musso, G.] Gradenigo Hosp, I-10132 Turin, Italy.
   [Gambino, R.; Cassader, M.] Univ Turin, Dept Internal Med, Turin, Italy.
C3 Humanitas Hospital Gradenigo; University of Turin
RP Musso, G (corresponding author), Gradenigo Hosp, Cso R Margherita 8, I-10132 Turin, Italy.
EM giovanni_musso@yahoo.it
RI GAMBINO, Roberto/AAC-7517-2022; Musso, Giovanni/AAB-7884-2022
FU Piedmont Regional Funds Comitato Interministeriale per la Programmazione
   Economica
FX Financial support/disclosure: this work was supported in part by grants
   from the Piedmont Regional Funds Comitato Interministeriale per la
   Programmazione Economica 2008.
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NR 165
TC 131
Z9 146
U1 0
U2 18
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1467-7881
EI 1467-789X
J9 OBES REV
JI Obes. Rev.
PD JUN
PY 2010
VL 11
IS 6
BP 430
EP 445
DI 10.1111/j.1467-789X.2009.00657.x
PG 16
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 600JI
UT WOS:000277981600003
PM 19845871
OA Green Published
DA 2025-06-11
ER

PT J
AU Bagi, Z
AF Bagi, Zsolt
TI Mechanisms of coronary microvascular adaptation to obesity
SO AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE
   PHYSIOLOGY
LA English
DT Review
DE obesity; arteriole; H2O2; cyclooxygenase-2; adipokines
ID PERIVASCULAR ADIPOSE-TISSUE; SOLUBLE GUANYLATE-CYCLASE; NITRIC-OXIDE
   SYNTHASE; CA2+-ACTIVATED K+ CHANNEL; PROTEIN-KINASE-C; NONSTEROIDAL
   ANTIINFLAMMATORY DRUGS; ENDOTHELIUM-DEPENDENT RELAXATION; ACTIVATED
   RECEPTOR-GAMMA; HYDROGEN-PEROXIDE; OXIDATIVE STRESS
AB Bagi Z. Mechanisms of coronary microvascular adaptation to obesity. Am J Physiol Regul Integr Comp Physiol 297: R556-R567, 2009. First published June 17, 2009; doi: 10.1152/ajpregu.90817.2008.-The metabolic syndrome (MetS) is associated with clustering of cardiovascular risk factors in individuals that may greatly increase their risk of developing coronary artery disease. Obesity and related metabolic dysfunction are the driving forces in the prevalence of MetS. It is believed that obesity has detrimental effects on cardiovascular function, but its overall impact on the vasomotor regulation of small coronary arteries is still debated. Emerging evidence indicates that in obesity coronary arteries adapt to hemodynamic changes via maintaining and/or upregulating cellular mechanism(s) intrinsic to the vascular wall. Among other factors, endothelial production of cyclooxygenase-2-derived prostacyclin and reactive oxygen species, as well as increased nitric oxide sensitivity and potassium channel activation in smooth muscle cells, have been implicated in maintaining coronary vasodilator function. This review aims to examine studies that have been primarily focused on alterations in coronary vasodilator function in obesity. A better understanding of cellular mechanisms that may contribute to coronary microvascular adaptation may provide insight into the sequence of pathological events in obesity and may allow the harnessing of these effects for therapeutic purposes.
C1 New York Med Coll, Dept Physiol, Valhalla, NY 10595 USA.
C3 New York Medical College
RP Bagi, Z (corresponding author), New York Med Coll, Dept Physiol, Valhalla, NY 10595 USA.
EM zsolt_bagi@nymc.edu
OI Bagi, Zsolt/0000-0001-8755-2980
FU American Heart Association [0735540T]; American Heart Association (AHA)
   [0735540T] Funding Source: American Heart Association (AHA)
FX Z. Bagi is supported by American Heart Association Grant 0735540T.
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NR 156
TC 30
Z9 34
U1 0
U2 1
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0363-6119
EI 1522-1490
J9 AM J PHYSIOL-REG I
JI Am. J. Physiol.-Regul. Integr. Comp. Physiol.
PD SEP
PY 2009
VL 297
IS 3
BP R556
EP R567
DI 10.1152/ajpregu.90817.2008
PG 12
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA 498YN
UT WOS:000270182700003
PM 19535672
DA 2025-06-11
ER

PT J
AU Mishra, A
   Cheng, CH
   Lee, WC
   Tsai, LL
AF Mishra, Archana
   Cheng, Chung-Hsien
   Lee, Wen-Chien
   Tsai, Ling-Ling
TI Proteomic changes in the hypothalamus and retroperitoneal fat from male
   F344 rats subjected to repeated light-dark shifts
SO PROTEOMICS
LA English
DT Article
DE Animal proteomics; Circadian rhythms; Energy intake; Fat; Obese; Shift
   work
ID BODY-MASS INDEX; ACID-BINDING PROTEIN; OBESE ZUCKER RATS; CIRCADIAN
   CLOCK; ADIPOSE-TISSUE; WEIGHT-GAIN; METABOLIC SYNDROME;
   GABA-TRANSAMINASE; NIGHT-WORK; REENTRAINMENT
AB Chronic circadian desynchronization induced by repeated 12 h light-dark cycle shifts conducted twice weekly resulted in elevated food intake, body weight gain, and retroperitoneal fat mass in male F344 rats. Using a proteomic approach, we found that repeated light-dark shifts caused changes in expression levels of five hypothalamic (four upregulated) and 22 retroperitoneal fat (13 upregulated) 2-DE protein spots. Proteins involved in carbohydrate metabolism and in the citric acid cycle were upregulated, indicating a positive energy balance status. In addition, the hypothalamic gamma-amino butyric acid (GABA) aminotransferase was upregulated, thus suggesting a connection between the brain GABAeric system and the modulation of food intake. Furthermore, the upregulation of fatty acid-binding protein 4 and the downregulation of 78 kDa glucose-regulated protein in the fat implicated the development of insulin resistance. We observed the upregulation of two antioxidant enzymes that might serve as protection against insulin dysfunction associated with oxidative stress. Finally, the downregulation of hypothalamic voltage-dependent anion-selective channel protein 1 and fat ATP synthase suggested a reduction in synthesis of mitochondrial ATP. These findings are in partial agreement with those of studies of obesity induced by genotype and a high-fat diet.
C1 [Mishra, Archana; Tsai, Ling-Ling] Natl Chung Cheng Univ, Dept Psychol, Chiayi Cty 62102, Taiwan.
   [Cheng, Chung-Hsien; Lee, Wen-Chien] Natl Chung Cheng Univ, Dept Chem Engn, Chiayi, Taiwan.
C3 National Chung Cheng University; National Chung Cheng University
RP Tsai, LL (corresponding author), Natl Chung Cheng Univ, Dept Psychol, 168 Univ Rd, Chiayi Cty 62102, Taiwan.
EM psyllt@ccu.edu.tw
RI MISHRA, ARCHANA/J-4352-2015
OI Tsai, Ling-Ling/0000-0002-9795-530X; Lee, Wen-Chien/0000-0001-9041-1396
FU National Science Council (NSC), Taiwan [NSC95-2413-H-194-029-MY2,
   NSC95-2811-H-194-002, NSC96-2811-H-194-001]
FX This work was supported by the National Science Council (NSC), Taiwan R.
   O. C., Grant NSC95-2413-H-194-029-MY2. AM was supported by the NSC
   Postdoctoral Research Fellow Grants NSC95-2811-H-194-002 and
   NSC96-2811-H-194-001. We thank Yu-Che Tsai and Kuang-Jen Huang for their
   assistance in tissue dissection, Wan-Chen Wang for her participation in
   the proteome experiment, Wen-Peng Lin and Yu-Chin Chen for their work on
   the LC-MS/MS analysis performed in the Department of Chemistry and
   Biochemistry at the National Chung Cheng University, and Ya-Wen Liu,
   Fan-Ci Hsiao, YuShan Huang, and Chun-Yu Chen for their work on the
   western blot analysis performed at Dr. Hsien-Bin Huang's laboratory in
   the Department of Life Sciences at the National Chung Cheng University.
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NR 66
TC 15
Z9 17
U1 0
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1615-9853
EI 1615-9861
J9 PROTEOMICS
JI Proteomics
PD AUG
PY 2009
VL 9
IS 16
BP 4017
EP 4028
DI 10.1002/pmic.200800813
PG 12
WC Biochemical Research Methods; Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 494AI
UT WOS:000269781100006
PM 19658099
DA 2025-06-11
ER

PT J
AU Lê, KA
   Tappy, L
AF Le, Kim-Anne
   Tappy, Luc
TI Metabolic effects of fructose
SO CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE
LA English
DT Article
DE cardiovascular risk; dietary sugars; ectopic lipids; insulin resistance;
   lipogenesis
ID INDUCED INSULIN-RESISTANCE; NECROSIS-FACTOR-ALPHA; PROTEIN-KINASE-C;
   GLUCOSE-METABOLISM; DIETARY FRUCTOSE; ADIPOSE-TISSUE; FATTY-ACIDS;
   COUNTERREGULATORY RESPONSES; TRIGLYCERIDE CONCENTRATION; HEPATIC
   LIPOGENESIS
AB Purpose of review
   Fructose is consumed in significant amounts in Western diets. An increase in fructose consumption over the past 10-20 years has been linked with a rise in obesity and metabolic disorders. Fructose/sucrose produces deleterious metabolic effects in animal models. This raises concern regarding the short-term and long-term effects of fructose and its risk in humans.
   Recent findings
   In rodents, fructose stimulates lipogenesis and leads to hepatic and extrahepatic insulin resistance, dyslipidaemia and high blood pressure. Insulin resistance appears to be related to ectopic lipid deposition. In humans, short-term fructose feeding increases de-novo lipogenesis and blood triglycerides and causes hepatic insulin resistance. There is presently no evidence for fructose-induced muscle insulin resistance in humans. The cellular mechanisms underlying the metabolic effects of fructose involve production of reactive oxygen species, activation of cellular stress pathways and possibly an increase in uric acid synthesis.
   Summary
   Consuming large amounts of fructose can lead to the development of a complete metabolic syndrome in rodents. In humans, fructose consumed in moderate to high quantities in the diet increases plasma triglycerides and alters hepatic glucose homeostasis, but does not appear to cause muscle insulin resistance or high blood pressure in the short term. Further human studies are required to delineate the effects of fructose in humans.
C1 Univ Lausanne, Fac Med, Dept Physiol, CH-1005 Lausanne, Switzerland.
   Univ Hosp, Serv Endocrinol Diabet & Metab, Lausanne, Switzerland.
C3 University of Geneva; University of Lausanne; University of Lausanne;
   Centre Hospitalier Universitaire Vaudois (CHUV)
RP Tappy, L (corresponding author), Univ Lausanne, Fac Med, Dept Physiol, 7 Rue Bugnon, CH-1005 Lausanne, Switzerland.
EM luc.tappy@unil.ch
RI Tappy, Luc/A-8911-2017
OI Tappy, Luc/0000-0001-8469-4692
CR [Anonymous], RECENT RES DEV PHYSL
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NR 72
TC 189
Z9 217
U1 1
U2 32
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1363-1950
J9 CURR OPIN CLIN NUTR
JI Curr. Opin. Clin. Nutr. Metab. Care
PD JUL
PY 2006
VL 9
IS 4
BP 469
EP 475
DI 10.1097/01.mco.0000232910.61612.4d
PG 7
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 064PM
UT WOS:000239101600020
PM 16778579
DA 2025-06-11
ER

PT J
AU Capozzi, A
   Vignali, M
   Scambia, G
   Lello, S
AF Capozzi, Anna
   Vignali, Michele
   Scambia, Giovanni
   Lello, Stefano
TI Pathophysiology and diagnostic criteria of PCOS
SO MINERVA OBSTETRICS AND GYNECOLOGY
LA English
DT Review; Early Access
DE Polycystic ovary syndrome; Physiology; Genetics; Diagnosis; Insulin;
   Vitamin D
ID POLYCYSTIC-OVARY-SYNDROME; INSULIN-RESISTANCE; VITAMIN-D; ANDROGEN
   EXCESS; METABOLIC DISTURBANCES; OXIDATIVE STRESS; VISCERAL FAT;
   RISK-FACTORS; BODY-FAT; WOMEN
AB INTRODUCTION: Polycystic ovary syndrome (PCOS) is a heterogeneous endocrine-metabolic syndrome mainly characterized by ovarian dysfunction, which is only one manifestation of a more complex syndrome with a significant systemic impact. EVIDENCE ACQUISITION: We review scientific literature on the pathophysiology and diagnosis of PCOS evaluating the most relevant data from original articles, reviews and meta-analyses published until June 2024. EVIDENCE SYNTHESIS: From a pathophysiological point of view, the concurrence of both metabolic aspects, such as insulin resistance and obesity, and hormonal alterations, such as hyperandrogenemia, might produce the most relevant clinical signs and/symptoms of this syndrome, for instance menstrual irregularities, hair loss, acne and hirsutism. In the latest years, many pieces of evidence highlighted the importance of family history and genetics in the development of the syndrome during adolescence and adult life. According to the available data, hypovitaminosis D could play a detrimental role in the pathogenesis and clinical manifestations of PCOS. CONCLUSIONS: PCOS is a challenging endocrine and metabolic dysfunction, due to its different expression among women and to the difficulty in obtaining an accurate diagnosis. The most appropriate approach to women affected by PCOS should involve a multi-step strategy, taking into account the characteristics of each patient, in order to identify the best non-pharmacologic and pharmacologic approach to manage both short- and medium-, and long-term sequelae.
C1 [Capozzi, Anna; Scambia, Giovanni; Lello, Stefano] Fdn Policlin Univ Agostino Gemelli IRCCS, Largo Francesco Vito 8, I-00168 Rome, Italy.
   [Vignali, Michele] Univ Milan, Dept Biomed Sci Hlth, Milan, Italy.
C3 Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli;
   University of Milan
RP Capozzi, A (corresponding author), Fdn Policlin Univ Agostino Gemelli IRCCS, Largo Francesco Vito 8, I-00168 Rome, Italy.
EM anna.capozzi@guest.policlinicogemelli.it
RI Vignali, Michele/L-1597-2016; Lello, Stefano/ADU-2239-2022; Capozzi,
   Anna/AAF-2793-2019
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NR 91
TC 0
Z9 0
U1 1
U2 1
PU EDIZIONI MINERVA MEDICA
PI TURIN
PA CORSO BRAMANTE 83-85 INT JOURNALS DEPT., 10126 TURIN, ITALY
SN 2724-606X
EI 2724-6450
J9 MINERVA OBSTET GYNEC
JI Minerva Obstet. Gynecol.
PD 2025 JAN 30
PY 2025
DI 10.23736/S2724-606X.24.05612-4
EA JAN 2025
PG 12
WC Obstetrics & Gynecology
WE Emerging Sources Citation Index (ESCI)
SC Obstetrics & Gynecology
GA X0Z2C
UT WOS:001422729300001
PM 39883425
DA 2025-06-11
ER

PT J
AU Xia, XJ
   Li, GN
   Dong, QL
   Wang, JW
   Kim, JE
AF Xia, Xuejuan
   Li, Guannan
   Dong, Qingli
   Wang, Jiong-Wei
   Kim, Jung Eun
TI Endothelial progenitor cells as an emerging cardiovascular risk factor
   in the field of food and nutrition research: advances and challenges
SO CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
LA English
DT Review
DE Blood outgrowth endothelial cells; cardiovascular disease; EPC
   characterization; food; nutrients
ID ISCHEMIA-INDUCED NEOVASCULARIZATION; GREEN TEA CONSUMPTION;
   COLONY-FORMING CELLS; RED WINE; MEDITERRANEAN DIET; PERIPHERAL-BLOOD;
   METABOLIC SYNDROME; OXIDATIVE STRESS; ANGIOTENSIN-II; NUMBER
AB Dietary modifications can help prevent many cardiovascular disease (CVD) events. Endothelial progenitor cells (EPCs) actively contribute to cardiovascular system maintenance and could function as surrogate markers for evaluating improvement in cardiovascular health resulting from nutritional interventions. This review summarizes the latest research progress on the impact of food and nutrients on EPCs, drawing on evidence from human, animal, and in vitro studies. Additionally, current trends and challenges faced in the field are highlighted. Findings from studies examining cells as EPCs are generally consistent, demonstrating that a healthy diet, such as the Mediterranean diet or a supervised diet for overweight people, specific foods like olive oil, fruit, vegetables, red wine, tea, chia, and nutraceuticals, and certain nutrients such as polyphenols, unsaturated fats, inorganic nitrate, and vitamins, generally promote higher EPC numbers and enhanced EPC function. Conversely, an unhealthy diet, such as one high in sugar substitutes, salt, or fructose, impairs EPC function. Research on outgrowth EPCs has revealed that various pathways are involved in the modulation effects of food and nutrients. The potential of EPCs as a biomarker for assessing the effectiveness of nutritional interventions in preventing CVDs is immense, while further clarification on definition and characterization of EPCs is required.
C1 [Xia, Xuejuan; Dong, Qingli] Univ Shanghai Sci & Technol, Sch Hlth Sci & Engn, Shanghai, Peoples R China.
   [Xia, Xuejuan; Kim, Jung Eun] Natl Univ Singapore, Dept Food Sci Technol, Fac Sci, Singapore, Singapore.
   [Li, Guannan] Southwest Univ, Coll Sericulture Text & Biomass, State Key Lab Silkworm Genome Biol, Chongqing, Peoples R China.
   [Wang, Jiong-Wei] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Surg, Singapore, Singapore.
   [Wang, Jiong-Wei] Natl Univ Hlth Syst, Cardiovasc Res Inst, Ctr Translat Med, Singapore, Singapore.
   [Wang, Jiong-Wei] Natl Univ Singapore, Yong Loo Lin Sch Med, Ctr NanoMed, Nanomed Translat Res Programme, Singapore, Singapore.
C3 University of Shanghai for Science & Technology; National University of
   Singapore; Southwest University - China; National University of
   Singapore; National University of Singapore; National University of
   Singapore
RP Kim, JE (corresponding author), Natl Univ Singapore, Dept Food Sci Technol, Fac Sci, Singapore, Singapore.
EM fstkje@nus.edu.sg
RI Dong, Qingli/CAF-9011-2022; Kim, Jung Eun/LWI-5710-2024; Li,
   Guannan/KHY-5970-2024; Wang, Jiong-Wei/AER-0814-2022
OI Dong, Qingli/0000-0001-9019-0001; Wang, Jiong-Wei/0000-0001-7986-6082
FU National University of Singapore [R160-000-A03-133]; Singapore Ministry
   of Education [R160-000-A26-114, R-160-000-010-114]; Singapore Ministry
   of Health's National Medical Research Council [NMRC/OFYIRG/0081/2018]
FX The authors acknowledge the financial support from the National
   University of Singapore [R160-000-A03-133]; the Singapore Ministry of
   Education [R160-000-A26-114 and R-160-000-010-114]; and the Singapore
   Ministry of Health's National Medical Research Council
   [NMRC/OFYIRG/0081/2018].
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NR 120
TC 4
Z9 4
U1 1
U2 9
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1040-8398
EI 1549-7852
J9 CRIT REV FOOD SCI
JI Crit. Rev. Food Sci. Nutr.
PD DEC 16
PY 2024
VL 64
IS 33
BP 12166
EP 12183
DI 10.1080/10408398.2023.2248506
EA AUG 2023
PG 18
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA N5B1B
UT WOS:001168542800001
PM 37599627
DA 2025-06-11
ER

PT J
AU Chilaka, C
   Toozs-Hobson, P
   Chilaka, V
AF Chilaka, Chioma
   Toozs-Hobson, Philip
   Chilaka, Victor
TI Pelvic floor dysfunction and obesity
SO BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
LA English
DT Article
DE Obesity; Overweight; Lower urinary tract symptoms (LUTS); Pelvic floor
   dysfunction (PFD); Urinary incontinence; Overactive bladder symptoms
   (OAB); Detrusor overactivity (DO)
ID BODY-MASS INDEX; STRESS URINARY-INCONTINENCE; WEIGHT-LOSS; OVERACTIVE
   BLADDER; METABOLIC SYNDROME; BARIATRIC SURGERY; ORGAN PROLAPSE;
   DIABETES-MELLITUS; NATURAL-HISTORY; TRACT SYMPTOMS
AB Obesity is a growing condition within the society and more patients, who have underlying obesity, are presenting with lower urinary tract symptoms (LUTS) and pelvic floor dysfunction (PFD). The effect of obesity on general health has been well documented, and its impact on the cardiovascular, endocrine, and musculoskeletal systems has been extensively studied. There is now a growing body of evidence on the effects of obesity on the female urogenital system. It seems to influence the prevalence, presentation, assessment, management, and outcome of various types of LUTS and PFD. A holistic approach is needed to assess and manage these patients. A clear understanding of the functions of the pelvic floor and the way it can be affected by obesity is essential in providing holistic care to this group. A frank discussion about patient weight is required in the clinics handling PFD. A multimodal approach to weight loss would help improve PFD symptoms and progression. Patients with obesity should still be offered standard treatment options for all PFDs and should not be forced to lose weight as a prerequisite before starting treatment. However, they should also be made aware of the impediments that being overweight adds to their care and their expectations should be managed accordingly.
C1 [Chilaka, Chioma; Toozs-Hobson, Philip] Birmingham Womens Hosp, Birmingham, England.
   [Chilaka, Victor] Hamad Med Corp, Womens Wellness & Res Ctr, Doha, Qatar.
C3 Birmingham Women's Hospital; Hamad Medical Corporation
RP Chilaka, C (corresponding author), Birmingham Womens Hosp, Birmingham, England.
EM Chioma.chilaka@nhs.net; p.toozs-hobson@nhs.net; vnchilaka@yahoo.com
OI Chilaka, Victor Ngozi/0000-0003-1101-2472
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NR 103
TC 14
Z9 16
U1 4
U2 7
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 1521-6934
EI 1532-1932
J9 BEST PRACT RES CL OB
JI Best Pract. Res. Clin. Obstet. Gynaecol.
PD AUG
PY 2023
VL 90
AR 102389
DI 10.1016/j.bpobgyn.2023.102389
EA AUG 2023
PG 17
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA P6FY0
UT WOS:001051625000001
PM 37541114
DA 2025-06-11
ER

PT J
AU Lima-Posada, I
   Stephan, Y
   Soulie, M
   Palacios-Ramirez, R
   Bonnard, B
   Nicol, L
   Kolkhof, P
   Jaisser, F
   Mulder, P
AF Lima-Posada, Ixchel
   Stephan, Yohan
   Soulie, Matthieu
   Palacios-Ramirez, Roberto
   Bonnard, Benjamin
   Nicol, Lionel
   Kolkhof, Peter
   Jaisser, Frederic
   Mulder, Paul
TI Benefits of the Non-Steroidal Mineralocorticoid Receptor Antagonist
   Finerenone in Metabolic Syndrome-Related Heart Failure with Preserved
   Ejection Fraction
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE diabetes; heart failure; mineralocorticoid receptor antagonist;
   diastolic dysfunction; finerenone
ID CHRONIC KIDNEY-DISEASE; OXIDATIVE STRESS; RENAL INJURY; ALDOSTERONE;
   NEPHROPATHY; CONTRIBUTES; DYSFUNCTION; OBESITY; SPIRONOLACTONE;
   ACTIVATION
AB The mineralocorticoid receptor (MR) plays an important role in the development of chronic kidney disease (CKD) and associated cardiovascular complications. Antagonizing the overactivation of the MR with MR antagonists (MRA) is a therapeutic option, but their use in patients with CKD is limited due to the associated risk of hyperkalemia. Finerenone is a non-steroidal MRA associated with an improved benefit-risk profile in comparison to steroidal MRAs. In this study, we decided to test whether finerenone improves renal and cardiac function in male hypertensive and diabetic ZSF1 rats as an established preclinical HFpEF model. Finerenone was administered at 10 mg/kg/day for 12 weeks. Cardiac function/hemodynamics were assessed in vivo. ZSF1 rats showed classical signs of CKD with increased BUN, UACR, hypertrophy, and fibrosis of the kidney together with characteristic signs of HFpEF including cardiac fibrosis, diastolic dysfunction, and decreased cardiac perfusion. Finerenone treatment did not impact kidney function but reduced renal hypertrophy and cardiac fibrosis. Interestingly, finerenone ameliorated diastolic dysfunction and cardiac perfusion in ZSF1 rats. In summary, we show for the first time that non-steroidal MR antagonism by finerenone attenuates cardiac diastolic dysfunction and improves cardiac perfusion in a preclinical HFpEF model. These cardiac benefits were found to be largely independent of renal benefits.
C1 [Lima-Posada, Ixchel; Soulie, Matthieu; Palacios-Ramirez, Roberto; Bonnard, Benjamin; Jaisser, Frederic] Univ Paris Cite, Sorbonne Univ, Ctr Rech Cordeliers, UMRS 1138,INSERM, F-75006 Paris, France.
   [Stephan, Yohan; Soulie, Matthieu; Nicol, Lionel; Mulder, Paul] Univ Rouen Normandie, INSERM EnVI UMR 1096, F-76183 Rouen, France.
   [Kolkhof, Peter] Bayer AG, Cardiovasc Precis Med Res & Early Dev, Pharmaceut, D-42113 Wuppertal, Germany.
   [Jaisser, Frederic] INI CRCT Cardiovasc & Renal Clin Trialists, French Clin Res Infrastruct Network F CRIN, Clin Invest Ctr 1433, INSERM, F-54500 Nancy, France.
C3 Universite Paris Cite; Institut National de la Sante et de la Recherche
   Medicale (Inserm); Sorbonne Universite; Institut National de la Sante et
   de la Recherche Medicale (Inserm); Universite de Rouen Normandie; Bayer
   AG; Institut National de la Sante et de la Recherche Medicale (Inserm)
RP Jaisser, F (corresponding author), Univ Paris Cite, Sorbonne Univ, Ctr Rech Cordeliers, UMRS 1138,INSERM, F-75006 Paris, France.; Jaisser, F (corresponding author), INI CRCT Cardiovasc & Renal Clin Trialists, French Clin Res Infrastruct Network F CRIN, Clin Invest Ctr 1433, INSERM, F-54500 Nancy, France.
EM frederic.jaisser@inserm.fr
RI Kolkhof, Peter/IST-3079-2023; Palacios-Ramirez, Roberto/H-9905-2015
OI Kolkhof, Peter/0000-0003-3425-7528; SOULIE,
   Matthieu/0000-0002-5169-1628; Lima Posada, Ixchel/0000-0003-1409-4581;
   STEPHAN, Yohan/0000-0002-2470-0058; Nicol, Lionel/0000-0002-7820-4148;
   BONNARD, BENJAMIN/0000-0002-1746-9580; Palacios-Ramirez,
   Roberto/0000-0002-0867-1277
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NR 62
TC 14
Z9 15
U1 0
U2 9
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD FEB
PY 2023
VL 24
IS 3
AR 2536
DI 10.3390/ijms24032536
PG 14
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 8V1WS
UT WOS:000930429500001
PM 36768859
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Brinchmann, BC
   Holme, JA
   Frerker, N
   Rambol, MH
   Karlsen, T
   Brinchmann, JE
   Kubátová, A
   Kukowski, K
   Skuland, T
   Ovrevik, J
AF Brinchmann, Bendik C.
   Holme, Jorn A.
   Frerker, Nadine
   Rambol, Mia H.
   Karlsen, Tommy
   Brinchmann, Jan E.
   Kubatova, Alena
   Kukowski, Klara
   Skuland, Tonje
   Ovrevik, Johan
TI Effects of organic chemicals from diesel exhaust particles on adipocytes
   differentiated from human mesenchymal stem cells
SO BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
LA English
DT Article
DE adipocytes; air pollution; diesel exhaust particles; inflammation;
   mesenchymal stem cells; metabolic syndrome; organic chemicals; PAHs
ID POLYCYCLIC AROMATIC-HYDROCARBONS; PARTICULATE AIR-POLLUTION;
   ADIPOSE-TISSUE; DIABETES-MELLITUS; WOOD SMOKE; INFLAMMATION; MATTER;
   ASSOCIATION; FRACTIONS; INDUCTION
AB Exposure to fine particulate matter (PM2.5) from incomplete fossil fuel combustion (coal, oil, gas and diesel) has been linked to increased morbidity and mortality due to metabolic diseases. PM2.5 exaggerate adipose inflammation and insulin resistance in mice with diet-induced obesity. Here, we elucidate the hypothesis that such systemic effects may be triggered by adhered particle components affecting adipose tissue directly. Studying adipocytes differentiated from primary human mesenchymal stem cells, we found that lipophilic organic chemicals (OC) from diesel exhaust particles induced inflammation-associated genes and increased secretion of the chemokine CXLC8/interleukin-8 as well as matrix metalloprotease 1. The oxidative stress response gene haem oxygenase-1 and tumour necrosis factor alpha were seemingly not affected, while aryl hydrocarbon receptor-regulated genes, cytochrome P450 1A1 (CYP1A1) and CYP1B1 and plasminogen activator inhibitor-2, were clearly up-regulated. Finally, expression of beta-adrenergic receptor, known to regulate adipocyte homoeostasis, was down-regulated by exposure to these lipophilic OC. Our results indicate that low concentrations of OC from combustion particles have the potential to modify expression of genes in adipocytes that may be linked to metabolic disease. Further studies on mechanisms linking PM exposure and metabolic diseases are warranted.
C1 [Brinchmann, Bendik C.; Holme, Jorn A.; Skuland, Tonje; Ovrevik, Johan] Norwegian Inst Publ Hlth, Dept Air Pollut & Noise, Domain Infect Control Environm & Hlth, Oslo, Norway.
   [Brinchmann, Bendik C.] Natl Inst Occupat Hlth, Dept Occupat Med & Epidemiol, Pb 5330, N-0304 Oslo, Norway.
   [Frerker, Nadine; Rambol, Mia H.; Karlsen, Tommy; Brinchmann, Jan E.] Oslo Univ Hosp, Norwegian Ctr Stem Cell Res, Dept Immunol, Oslo, Norway.
   [Kubatova, Alena; Kukowski, Klara] Univ North Dakota, Dept Chem, Grand Forks, ND USA.
C3 Norwegian Institute of Public Health (NIPH); University of Oslo;
   University of North Dakota Grand Forks
RP Brinchmann, BC (corresponding author), Natl Inst Occupat Hlth, Dept Occupat Med & Epidemiol, Pb 5330, N-0304 Oslo, Norway.
EM bendik.brinchmann@stami.no
OI Brinchmann, Bendik/0000-0001-8023-1148
FU Research Council of Norway through the Environmental Exposures and
   Health Outcomes program [228143]
FX The work at NIPH was supported by the Research Council of Norway through
   the Environmental Exposures and Health Outcomes program (Grant No.
   228143).
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NR 64
TC 7
Z9 7
U1 3
U2 16
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-7835
EI 1742-7843
J9 BASIC CLIN PHARMACOL
JI Basic Clin. Pharmacol. Toxicol.
PD JAN
PY 2023
VL 132
IS 1
BP 83
EP 97
DI 10.1111/bcpt.13805
EA OCT 2022
PG 15
WC Pharmacology & Pharmacy; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Toxicology
GA 9D5AJ
UT WOS:000869544800001
PM 36214226
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Khan, MH
   Pathak, S
   Yadav, U
   Rochlani, Y
   Aronow, WS
AF Hasan Khan, Mohammed
   Pathak, Surabhi
   Yadav, Udit
   Rochlani, Yogita
   Aronow, Wilbert S.
TI Hypertension in Cancer Survivors
SO CURRENT HYPERTENSION REPORTS
LA English
DT Review
DE Hypertension; Blood pressure; Cancer survivorship; Vascular endothelial
   growth factor inhibition; VEGF
ID CARDIOVASCULAR RISK-FACTORS; METABOLIC SYNDROME; BLOOD-PRESSURE; CLONAL
   HEMATOPOIESIS; OXIDATIVE STRESS; BREAST; INFLAMMATION; PATHWAY; AGE;
   BEVACIZUMAB
AB Purpose of Review With increasing survival after cancer treatment, there is a need for long-term management of risk factors and chronic medical conditions to realize the full benefit of improvement of outcomes. Hypertension is a major risk factor for cardiovascular disease and has a higher prevalence in cancer survivors compared to the general population. In this review article, we discuss the burden of hypertension in cancer survivors and how this impacts their long-term outcomes and risk of cancer recurrence. We then discuss the latest concepts regarding the pathophysiology of hypertension in cancer survivors in detail. There is a focus on inflammation and the role it plays in cancer and hypertension followed by a brief discussion on clonal hematopoiesis of indeterminate potential (CHIP) and associated hypertension. There is a brief review of various cancer therapies associated with development and worsening of hypertension control and the underlying mechanisms behind this. We conclude the review article by giving recommendations on blood pressure control in this unique patient population.
   Recent Findings A lot of newer anti-cancer therapies have been implicated in the development or worsening of hypertension. We summarize the latest data, explore associations between these therapies and hypertension, and review the latest understanding of the underlying mechanisms driving this process.
   Summary Hypertension is a major risk factor for cardiovascular disease in cancer survivors and must be recognized and treated promptly.
C1 [Hasan Khan, Mohammed; Pathak, Surabhi] Kings Daughters Med Ctr, Ashland, KY 41101 USA.
   [Yadav, Udit] Northern Alabama Med Ctr, Florence, AL USA.
   [Rochlani, Yogita] Montefiore Med Ctr, 111 E 210th St, Bronx, NY 10467 USA.
   [Aronow, Wilbert S.] New York Med Coll, Westchester Med Ctr, Valhalla, NY 10595 USA.
C3 Montefiore Medical Center; Albert Einstein College of Medicine;
   Westchester Medical Center; New York Medical College
RP Khan, MH (corresponding author), Kings Daughters Med Ctr, Ashland, KY 41101 USA.
EM mhasan87@gmail.com
RI Khan, Mohammed/ABE-9033-2020; Pathak, Surabhi/HLG-2610-2023
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NR 63
TC 4
Z9 4
U1 0
U2 11
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1522-6417
EI 1534-3111
J9 CURR HYPERTENS REP
JI Curr. Hypertens. Rep.
PD OCT
PY 2022
VL 24
IS 10
BP 435
EP 443
DI 10.1007/s11906-022-01208-2
EA JUL 2022
PG 9
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 4V8OF
UT WOS:000827390600001
PM 35852781
DA 2025-06-11
ER

PT J
AU Merola, C
   Vremere, A
   Fanti, F
   Iannetta, A
   Caioni, G
   Sergi, M
   Compagnone, D
   Lorenzetti, S
   Perugini, M
   Amorena, M
AF Merola, Carmine
   Vremere, Anton
   Fanti, Federico
   Iannetta, Annamaria
   Caioni, Giulia
   Sergi, Manuel
   Compagnone, Dario
   Lorenzetti, Stefano
   Perugini, Monia
   Amorena, Michele
TI Oxysterols Profile in Zebrafish Embryos Exposed to Triclocarban and
   Propylparaben-A Preliminary Study
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Article
DE oxysterols; propylparaben; triclocarban; zebrafish embryos; toxicity
ID ENDOCRINE DISRUPTORS; METABOLIC SYNDROME; TRICLOSAN; PARABENS;
   CHEMICALS; SCREENS; STRESS
AB Oxysterols have long been considered as simple by-products of cholesterol metabolism, but they are now fully designed as bioactive lipids that exert their multiple effects through their binding to several receptors, representing endogenous mediators potentially involved in several metabolic diseases. There is also a growing concern that metabolic disorders may be linked with exposure to endocrine-disrupting chemicals (EDCs). To date, there are no studies aimed to link EDCs exposure to oxysterols perturbation-neither in vivo nor in vitro studies. The present research aimed to evaluate the differences in oxysterols levels following exposure to two metabolism disrupting chemicals (propylparaben (PP) and triclocarban (TCC)) in the zebrafish model using liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS). Following exposure to PP and TCC, there were no significant changes in total and individual oxysterols compared with the control group; however, some interesting differences were noticed: 24-OH was detected only in treated zebrafish embryos, as well as the concentrations of 27-OH, which followed a different distribution, with an increase in TCC treated embryos and a reduction in zebrafish embryos exposed to PP at 24 h post-fertilization (hpf). The results of the present study prompt the hypothesis that EDCs can modulate the oxysterol profile in the zebrafish model and that these variations could be potentially involved in the toxicity mechanism of these emerging contaminants.
C1 [Merola, Carmine; Vremere, Anton; Fanti, Federico; Iannetta, Annamaria; Sergi, Manuel; Compagnone, Dario; Perugini, Monia; Amorena, Michele] Univ Teramo, Fac Biosci & Technol Food Agr & Environm, I-64100 Teramo, Italy.
   [Vremere, Anton; Lorenzetti, Stefano] Ist Super Sanita, Dept Food Safety Nutr & Vet Publ Hlth, I-00161 Rome, Italy.
   [Caioni, Giulia] Univ Aquila, Dept Life Hlth & Environm Sci, I-67100 Laquila, Italy.
C3 University of Teramo; Istituto Superiore di Sanita (ISS); University of
   L'Aquila
RP Perugini, M (corresponding author), Univ Teramo, Fac Biosci & Technol Food Agr & Environm, I-64100 Teramo, Italy.
EM cmerola@unite.it; avremere@unite.it; ffanti@unite.it;
   aiannetta@unite.it; giulia.caioni@guest.univaq.it; msergi@unite.it;
   dcompagnone@unite.it; stefano.lorenzetti@iss.it; mperugini@unite.it;
   mamorena@unite.it
RI Merola, Carmine/AAC-8769-2022; Caioni, Giulia/LCE-0230-2024; Fanti,
   Federico/ITT-1084-2023; Lorenzetti, Stefano/C-6063-2015
OI Lorenzetti, Stefano/0000-0001-5358-8002; Caioni,
   Giulia/0000-0002-2391-2999; Sergi, Manuel/0000-0002-1130-5294; Vremere,
   Anton/0000-0002-2939-5216; Compagnone, Dario/0000-0001-7849-8943; FANTI,
   FEDERICO/0000-0002-9235-5874; Perugini, Monia/0000-0003-4294-9866
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NR 54
TC 5
Z9 5
U1 1
U2 13
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD FEB
PY 2022
VL 19
IS 3
AR 1264
DI 10.3390/ijerph19031264
PG 11
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA YY5FJ
UT WOS:000754814600001
PM 35162288
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Mthembu, SXH
   Dludla, P
   Ziqubu, K
   Nyambuya, TM
   Kappo, AP
   Madoroba, E
   Nyawo, TA
   Nkambule, BB
   Silvestri, S
   Muller, CJF
   Mazibuko-Mbeje, SE
AF Mthembu, Sinenhlanhla X. H.
   Dludla, Phiwayinkosi, V
   Ziqubu, Khanyisani
   Nyambuya, Tawanda M.
   Kappo, Abidemi P.
   Madoroba, Evelyn
   Nyawo, Thembeka A.
   Nkambule, Bongani B.
   Silvestri, Sonia
   Muller, Christo J. F.
   Mazibuko-Mbeje, Sithandiwe E.
TI The Potential Role of Polyphenols in Modulating Mitochondrial
   Bioenergetics within the Skeletal Muscle: A Systematic Review of
   Preclinical Models
SO MOLECULES
LA English
DT Review
DE polyphenols; skeletal muscle; mitochondrial function; insulin
   resistance; metabolic syndrome
ID ENHANCED ORAL BIOAVAILABILITY; INSULIN-RESISTANCE; ZINGIBER-OFFICINALE;
   HIGH-CARBOHYDRATE; IN-VIVO; RESVERATROL; ICARIIN; RATS; ATHEROSCLEROSIS;
   FORMULATION
AB Polyphenols are naturally derived compounds that are increasingly being explored for their various health benefits. In fact, foods that are rich in polyphenols have become an attractive source of nutrition and a potential therapeutic strategy to alleviate the untoward effects of metabolic disorders. The last decade has seen a rapid increase in studies reporting on the bioactive properties of polyphenols against metabolic complications, especially in preclinical models. Various experimental models involving cell cultures exposed to lipid overload and rodents on high fat diet have been used to investigate the ameliorative effects of various polyphenols against metabolic anomalies. Here, we systematically searched and included literature reporting on the impact of polyphenols against metabolic function, particularly through the modulation of mitochondrial bioenergetics within the skeletal muscle. This is of interest since the skeletal muscle is rich in mitochondria and remains one of the main sites of energy homeostasis. Notably, increased substrate availability is consistent with impaired mitochondrial function and enhanced oxidative stress in preclinical models of metabolic disease. This explains the general interest in exploring the antioxidant properties of polyphenols and their ability to improve mitochondrial function. The current review aimed at understanding how these compounds modulate mitochondrial bioenergetics to improve metabolic function in preclinical models on metabolic disease.
C1 [Mthembu, Sinenhlanhla X. H.; Dludla, Phiwayinkosi, V; Nyawo, Thembeka A.; Muller, Christo J. F.] South African Med Res Council, Biomed Res & Innovat Platform, ZA-7505 Tygerberg, South Africa.
   [Mthembu, Sinenhlanhla X. H.; Madoroba, Evelyn; Muller, Christo J. F.] Univ Zululand, Dept Biochem & Microbiol, ZA-3886 Kwa Dlangezwa, South Africa.
   [Ziqubu, Khanyisani; Mazibuko-Mbeje, Sithandiwe E.] North West Univ, Fac Nat & Agr Sci, Dept Biochem, Mafikeng Campus,Private Bag X 2046, ZA-2735 Mmabatho, South Africa.
   [Nyambuya, Tawanda M.] Namibia Univ Sci & Technol, Fac Hlth & Appl Sci, Dept Hlth Sci, Windhoek 9000, Namibia.
   [Nyambuya, Tawanda M.; Nkambule, Bongani B.] Univ KwaZulu Natal, Coll Hlth Sci, Sch Lab Med & Med Sci, ZA-4000 Durban, South Africa.
   [Kappo, Abidemi P.] Univ Johannesburg, Fac Sci, Dept Biochem, Kingsway Campus, ZA-2006 Auckland Pk, South Africa.
   [Nyawo, Thembeka A.; Muller, Christo J. F.] Stellenbosch Univ, Fac Hlth Sci, Div Med Physiol, ZA-7505 Tygerberg, South Africa.
   [Silvestri, Sonia] Polytech Univ Marche, Dept Life & Environm Sci, I-60131 Ancona, Italy.
C3 South African Medical Research Council; University of Zululand; North
   West University - South Africa; Namibia University of Science &
   Technology; University of Kwazulu Natal; University of Johannesburg;
   Stellenbosch University; Marche Polytechnic University
RP Mazibuko-Mbeje, SE (corresponding author), North West Univ, Fac Nat & Agr Sci, Dept Biochem, Mafikeng Campus,Private Bag X 2046, ZA-2735 Mmabatho, South Africa.
EM sinenhlanhla.Mthembu@mrc.ac.za; ziqubukhanyisani@gmail.com;
   mnyambuya@nust.na; akappo@uj.ac.za; MadorobaE@unizulu.ac.za;
   Thembeka.Nyawo@mrc.ac.za; nkambuleb@ukzn.ac.za; s.silvestri@univpm.it;
   christo.muller@mrc.ac.za; 36588296@nwu.ac.za
RI Nyambuya, Tawanda Maurice/GLU-4124-2022; Nkambule,
   Bongani/ABD-7943-2022; Mazibuko-Mbeje, Sithandiwe/HPG-1119-2023
OI Nkambule, Bongani/0000-0001-8846-1992; Muller,
   Christo/0000-0001-6821-2120; Nyambuya, Tawanda
   Maurice/0000-0002-3288-9524; MTHEMBU, SINENHLANHLA/0000-0003-2747-1841;
   Kappo, Abidemi Paul/0000-0003-2521-8957; Silvestri,
   Sonia/0000-0003-3302-4335
FU National Research Foundation (NRF) of South Africa [128296]; NRF
   [113674]; Biomedical Research and Innovation Platform of the South
   African Medical Research Council (SAMRC)
FX This work was funded by the National Research Foundation (NRF) of South
   Africa Thuthuka Programme grant 128296 and NRF support for rated
   scientist 113674 to SE MazibukoMbeje. Baseline funding from Biomedical
   Research and Innovation Platform of the South African Medical Research
   Council (SAMRC) is also acknowledged. Grant holders acknowledge that
   opinions, findings and conclusions or recommendations expressed in any
   publication generated by the NRF or SAMRC supported research are those
   of the authors and that the NRF or SAMRC accepts no liability whatsoever
   in this regard.
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NR 64
TC 11
Z9 12
U1 0
U2 6
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1420-3049
J9 MOLECULES
JI Molecules
PD MAY
PY 2021
VL 26
IS 9
AR 2791
DI 10.3390/molecules26092791
PG 14
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA SC4QI
UT WOS:000650657400001
PM 34068459
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Nunn, AVW
   Guy, GW
   Brysch, W
   Botchway, SW
   Frasch, W
   Calabrese, EJ
   Bell, JD
AF Nunn, Alistair V. W.
   Guy, Geoffrey W.
   Brysch, Wolfgang
   Botchway, Stanley W.
   Frasch, Wayne
   Calabrese, Edward J.
   Bell, Jimmy D.
TI SARS-CoV-2 and mitochondrial health: implications of lifestyle and
   ageing
SO IMMUNITY & AGEING
LA English
DT Review
ID REDOX-OPTIMIZED ROS; NLRP3 INFLAMMASOME; OXIDATIVE-PHOSPHORYLATION;
   CALORIC RESTRICTION; VIRAL REPLICATION; VIRUS FACTORIES; SALICYLIC-ACID;
   INFLUENZA; EXERCISE; DYSFUNCTION
AB Infection with SARs-COV-2 displays increasing fatality with age and underlying co-morbidity, in particular, with markers of the metabolic syndrome and diabetes, which seems to be associated with a "cytokine storm" and an altered immune response. This suggests that a key contributory factor could be immunosenescence that is both age-related and lifestyle-induced. As the immune system itself is heavily reliant on mitochondrial function, then maintaining a healthy mitochondrial system may play a key role in resisting the virus, both directly, and indirectly by ensuring a good vaccine response. Furthermore, as viruses in general, and quite possibly this new virus, have also evolved to modulate immunometabolism and thus mitochondrial function to ensure their replication, this could further stress cellular bioenergetics. Unlike most sedentary modern humans, one of the natural hosts for the virus, the bat, has to "exercise" regularly to find food, which continually provides a powerful adaptive stimulus to maintain functional muscle and mitochondria. In effect the bat is exposed to regular hormetic stimuli, which could provide clues on how to resist this virus. In this paper we review the data that might support the idea that mitochondrial health, induced by a healthy lifestyle, could be a key factor in resisting the virus, and for those people who are perhaps not in optimal health, treatments that could support mitochondrial function might be pivotal to their long-term recovery.
C1 [Nunn, Alistair V. W.; Bell, Jimmy D.] Univ Westminster, Dept Life Sci, Res Ctr Optimal Hlth, London W1W 6UW, England.
   [Guy, Geoffrey W.] Guy Fdn, Cerne Abbas, Dorset, England.
   [Brysch, Wolfgang] MetrioPharm AG, Zurich, Switzerland.
   [Botchway, Stanley W.] Oxford Brookes Univ, STFC, Cent Laser Facil, UKRI, Didcot OX11 0QX, Oxon, England.
   [Botchway, Stanley W.] Oxford Brookes Univ, Dept Biol & Med Sci, Didcot OX11 0QX, Oxon, England.
   [Frasch, Wayne] Arizona State Univ, Sch Life Sci, Tempe, AZ USA.
   [Calabrese, Edward J.] Univ Massachusetts, Sch Publ Hlth & Hlth Sci, Environm Hlth Sci Div, Amherst, MA 01003 USA.
C3 University of Westminster; Oxford Brookes University; UK Research &
   Innovation (UKRI); Science & Technology Facilities Council (STFC); STFC
   Rutherford Appleton Laboratory; Oxford Brookes University; Arizona State
   University; Arizona State University-Tempe; University of Massachusetts
   System; University of Massachusetts Amherst
RP Nunn, AVW (corresponding author), Univ Westminster, Dept Life Sci, Res Ctr Optimal Hlth, London W1W 6UW, England.
EM a.nunn@westminster.ac.uk
RI Frasch, Wayne/HKF-3175-2023; Nunn, Alistair/ABE-2462-2020
OI Bell, Jimmy/0000-0003-3804-1281; Nunn, Alistair/0000-0003-0728-1995
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NR 287
TC 41
Z9 42
U1 0
U2 6
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1742-4933
J9 IMMUN AGEING
JI Immun. Ageing
PD NOV 9
PY 2020
VL 17
IS 1
AR 33
DI 10.1186/s12979-020-00204-x
PG 21
WC Geriatrics & Gerontology; Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology; Immunology
GA OP4WD
UT WOS:000588083300001
PM 33292333
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Al-Rashed, F
   Ahmad, Z
   Thomas, R
   Melhem, M
   Snider, AJ
   Obeid, LM
   Al-Mulla, F
   Hannun, YA
   Ahmad, R
AF Al-Rashed, Fatema
   Ahmad, Zunair
   Thomas, Reeby
   Melhem, Motasem
   Snider, Ashley J.
   Obeid, Lina M.
   Al-Mulla, Fahd
   Hannun, Yusuf A.
   Ahmad, Rasheed
TI Neutral sphingomyelinase 2 regulates inflammatory responses in
   monocytes/macrophages induced by TNF-α
SO SCIENTIFIC REPORTS
LA English
DT Article
ID NECROSIS-FACTOR-ALPHA; ACTIVATED PROTEIN-KINASE; HUMAN MONOCYTIC CELLS;
   MMP-9 EXPRESSION; ADIPOSE-TISSUE; COMPONENT; NSMASE2; STRESS; MAPK
AB Obesity is associated with elevated levels of TNF-alpha and proinflammatory CD11c monocytes/macrophages. TNF-alpha mediated dysregulation in the plasticity of monocytes/macrophages is concomitant with pathogenesis of several inflammatory diseases, including metabolic syndrome, but the underlying mechanisms are incompletely understood. Since neutral sphingomyelinase-2 (nSMase2: SMPD3) is a key enzyme for ceramide production involved in inflammation, we investigated whether nSMase2 contributed to the inflammatory changes in the monocytes/macrophages induced by TNF-alpha. In this study, we demonstrate that the disruption of nSMase activity in monocytes/macrophages either by chemical inhibitor GW4869 or small interfering RNA (siRNA) against SMPD3 results in defects in the TNF-alpha mediated expression of CD11c. Furthermore, blockage of nSMase in monocytes/macrophages inhibited the secretion of inflammatory mediators IL-1 beta and MCP-1. In contrast, inhibition of acid SMase (aSMase) activity did not attenuate CD11c expression or secretion of IL-1 beta and MCP-1. TNF-alpha-induced phosphorylation of JNK, p38 and NF-kappa B was also attenuated by the inhibition of nSMase2. Moreover, NF-kB/AP-1 activity was blocked by the inhibition of nSMase2. SMPD3 was elevated in PBMCs from obese individuals and positively corelated with TNF-alpha gene expression. These findings indicate that nSMase2 acts, at least in part, as a master switch in the TNF-alpha mediated inflammatory responses in monocytes/macrophages.
C1 [Al-Rashed, Fatema; Thomas, Reeby; Ahmad, Rasheed] Dasman Diabet Inst, Immunol & Microbiol Dept, Al Soor St,POB 1180, Kuwait 15462, Kuwait.
   [Ahmad, Zunair] Med Univ Bahrain, Royal Coll Surg Ireland, Sch Med, Busaiteen, Bahrain.
   [Melhem, Motasem; Al-Mulla, Fahd] Dasman Diabet Inst, Genet & Bioinformat Dept, Dasman 15462, Kuwait.
   [Snider, Ashley J.; Obeid, Lina M.; Hannun, Yusuf A.] SUNY Stony Brook, Stony Brook Canc Ctr, Stony Brook, NY 11794 USA.
   [Snider, Ashley J.] Univ Arizona, Coll Agr & Life Sci, Dept Nutr Sci, Tucson, AZ 85721 USA.
C3 Dasman Diabetes Institute (DDI); Royal College of Surgeons - Ireland;
   Royal College of Surgeons in Ireland - Medical University of Bahrain;
   Dasman Diabetes Institute (DDI); State University of New York (SUNY)
   System; Stony Brook University; University of Arizona
RP Ahmad, R (corresponding author), Dasman Diabet Inst, Immunol & Microbiol Dept, Al Soor St,POB 1180, Kuwait 15462, Kuwait.
EM rasheed.ahmad@dasmaninstitute.org
RI Ahmad, Rasheed/LMP-1937-2024; Al-Mulla, Fahd/E-2068-2015
OI THOMAS, REEBY/0000-0001-9933-0285; Al-rashed,
   fatema/0000-0002-5825-7701; Al-Mulla, Fahd/0000-0001-5409-3829
FU Kuwait Foundation for the Advancement of Sciences (KFAS) [RA AM 2016007,
   RA 2010-003]; NIH [GM118128]
FX This work was supported by Kuwait Foundation for the Advancement of
   Sciences (KFAS) Grant RA AM 2016007, RA 2010-003 to RA and NIH Grant
   GM118128 to YAH.
CR Ahmad R, 2008, BLOOD, V112, P2360, DOI 10.1182/blood-2008-02-137711
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NR 37
TC 46
Z9 49
U1 1
U2 13
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD OCT 8
PY 2020
VL 10
IS 1
AR 16802
DI 10.1038/s41598-020-73912-5
PG 12
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA OA0GJ
UT WOS:000577475100026
PM 33033337
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Stanescu, AMA
   Grajdeanu, IV
   Serban, B
   Diaconu, CC
AF Stanescu, Ana Maria Alexandra
   Grajdeanu, Ioana Veronica
   Serban, Bogdan
   Diaconu, Camelia Cristina
TI Distribution of Cardiovascular Risk Factors in Patients with Psoriasis
SO REVISTA DE CHIMIE
LA English
DT Article
DE psoriasis; cardiovascular diseases; metabolic syndrome
ID FOLLOW-UP; ASSOCIATION; STROKE; ARTERY
AB Psoriasis is a chronic inflammatory systemic disorder that associates many cardiovascular comorbidities. The association between psoriasis and cardiovascular disease is a complex one, which implies many risk factors, such as age, gender, heredity, smoking, alcohol and stress. The prognosis of patients with psoriasis may be improved by identifying and reduction of these cardiovascular risk factors. The objective of our study was to determine the prevalence of cardiovascular risk factors among patients with psoriasis from Bucharest and Ilfov county, Romania. 634 individuals from the general population were initially included. From these individuals, 208 patients with psoriasis have been selected for inclusion in our observational study. The patients were selected from Elias Emergency Hospital of Bucharest, Romania, and through the family doctors praxis, between 2010-2017. Of the 634 individuals from the general population, 208 patients (33%) were identified as patients with a diagnosis of vulgar psoriasis, confirmed by the dermatologist, forming the study group. The presence of risk factors is consistent with the presence of cardiovascular disease (23%) in the studied group. Patients with psoriasis, without cardiovascular diseases, have an increased risk of developing them throughout their lives. Patients with psoriasis have a very high risk of developing life-long cardiovascular disease, because of a multitude of risk factors associated with psoriasis. Intervention on modifiable risk factors for cardiovascular disease can be mediated by a family doctor, who can monitor the development over time and may also intervene early when appropriate.
C1 [Stanescu, Ana Maria Alexandra; Grajdeanu, Ioana Veronica; Serban, Bogdan; Diaconu, Camelia Cristina] Univ Med & Pharm Carol Davila, 8 Eroii Sanit Str, Bucharest 050474, Romania.
   [Serban, Bogdan] Emergency Univ Hosp Bucharest, 169 Splaiul Independentei, Bucharest 050098, Romania.
   [Diaconu, Camelia Cristina] Clin Emergency Hosp Bucharest, 8 Calea Floreasca, Bucharest 014461, Romania.
C3 Carol Davila University of Medicine & Pharmacy
RP Stanescu, AMA (corresponding author), Univ Med & Pharm Carol Davila, 8 Eroii Sanit Str, Bucharest 050474, Romania.
EM alexandrazotta@yahoo.com
RI Diaconu, Camelia/A-2144-2019; Stanescu, Ana/L-8439-2019
OI Stanescu, Ana Maria Alexandra/0000-0002-4807-9470
CR [Anonymous], 2008, Physical Activity Guidelines for Americans
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NR 30
TC 0
Z9 0
U1 0
U2 4
PU REVISTA CHIMIE SRL
PI BUCURESTI
PA CALES PLEVNEI NR 139A, SECTOR 6, BUCURESTI, ROMANIA
SN 0034-7752
J9 REV CHIM-BUCHAREST
JI Rev. Chim.
PD MAY
PY 2019
VL 70
IS 5
BP 1643
EP 1648
PG 6
WC Chemistry, Multidisciplinary; Engineering, Chemical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Engineering
GA IB2FZ
UT WOS:000470086400026
DA 2025-06-11
ER

PT J
AU Jiang, F
   Zhi, XY
   Xu, M
   Li, BY
   Zhang, ZL
AF Jiang, Fei
   Zhi, Xueyuan
   Xu, Miao
   Li, Bingyan
   Zhang, Zengli
TI Gender-specific differences of interaction between cadmium exposure and
   obesity on prediabetes in the NHANES 2007-2012 population
SO ENDOCRINE
LA English
DT Article
DE Cadmium; Obesity; Prediabetes; Interaction
ID NUTRITION EXAMINATION SURVEY; PERIPHERAL ARTERIAL-DISEASE; TYPE-2
   DIABETES-MELLITUS; NECROSIS-FACTOR-ALPHA; OXIDATIVE-STRESS; URINARY
   CADMIUM; INSULIN-RESISTANCE; METABOLIC SYNDROME; NATIONAL-HEALTH;
   EARLY-LIFE
AB Data from National Health and Nutrition Examination Survey (NHANES) for the years 2007-2012 were used to evaluate the interactions of cadmium (Cd) exposure with being overweight/obesity on the risk of prediabetes among adults 20 years older.
   A total of 3552 subjects were included in the analysis. Urinary cadmium levels (UCd) was used as a biomarker for long-term exposure to Cd. Additive interaction was estimated using relative excess risk due to interaction (RERI), attributable proportion due to interaction (AP) and synergy index (S).
   Following covariates adjustments, we found significant associations of UCd with higher prediabetes prevalence, and this association was more apparent in males (Q4 vs Q1: OR = 1.95, 95%CI: 1.34-2.84); while overweight/obesity was associated with prediabetes both in males and in females. Additionally, there was a significant interaction between Cd exposure and being overweight/obesity on prediabetes risk among males (RERI = 1.18, 95% CI: 0.42-1.93; AP = 0.35, 95% CI: 0.12-0.58; S = 2.00, 95% CI: 0.92-4.34).
   Our results suggest that being overweight/obesity may substantially amplify the adverse effects of long-term cadmium exposure on prediabetes risk, and this interaction is more severe in male adults. Further studies are needed to confirm these findings.
C1 [Jiang, Fei; Zhi, Xueyuan; Xu, Miao; Zhang, Zengli] Soochow Univ, Med Coll, Sch Publ Hlth, Dept Occupat & Environm Hlth, 199 Renai Rd, Suzhou 215123, Peoples R China.
   [Li, Bingyan] Soochow Univ, Med Coll, Sch Publ Hlth, Dept Nutr & Food Hyg, 199 Renai Rd, Suzhou 215123, Peoples R China.
C3 Soochow University - China; Soochow University - China
RP Zhang, ZL (corresponding author), Soochow Univ, Med Coll, Sch Publ Hlth, Dept Occupat & Environm Hlth, 199 Renai Rd, Suzhou 215123, Peoples R China.
EM zhangzengli@suda.edu.cn
RI li, bingyan/NDS-7931-2025
OI zhi, xueyuan/0000-0002-9372-9997
FU National Natural Science Foundation of China [81703209, 81773414,
   81673151]; Postdoctoral Science Foundation of Jiangsu Province, China
   Postdoctoral Science Foundation [2017M621823]; Priority Academic Program
   Development to Jiangsu Higher Education Institutions (PAPD)
FX This study was supported by the National Natural Science Foundation of
   China (No.81703209, No.81773414, and No.81673151), Postdoctoral Science
   Foundation of Jiangsu Province, China Postdoctoral Science Foundation
   (No.2017M621823), and A Project Funded by the Priority Academic Program
   Development to Jiangsu Higher Education Institutions (PAPD).
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NR 46
TC 17
Z9 18
U1 0
U2 17
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1355-008X
EI 1559-0100
J9 ENDOCRINE
JI Endocrine
PD AUG
PY 2018
VL 61
IS 2
BP 258
EP 266
DI 10.1007/s12020-018-1623-3
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA GN4LH
UT WOS:000438994200012
PM 29846900
DA 2025-06-11
ER

PT S
AU Uchida, S
   Kumagai, T
   Chang, WX
   Tamura, Y
   Shibata, S
AF Uchida, Shunya
   Kumagai, Takanori
   Chang, Wen Xiu
   Tamura, Yoshifuru
   Shibata, Shigeru
BE TrevinoBecerra, A
   Iseki, K
TI Time to Target Uric Acid to Retard Chronic Kidney Disease Progression
SO URIC ACID IN CHRONIC KIDNEY DISEASE
SE Contributions to Nephrology
LA English
DT Article; Book Chapter
ID RENAL-DISEASE; URATE TRANSPORTER; LOWERING THERAPY; CKD PROGRESSION;
   BLOOD-PRESSURE; RAT MODEL; HYPERURICEMIA; ALLOPURINOL; OUTCOMES; RISK
AB Uric acid (UA) remains a risk factor for the progression of chronic kidney disease (CKD). Most observational studies showed a slight elevation in the serum UA level and this independently predicts the incidence and development of CKD. The recent meta-analysis, however, did not reach the conclusion that urate-lowering therapy with allopurinol retards the progression of CKD. The target level of serum UA if treated is another issue of debate. Our recent analysis by propensity score analysis has shown that the serum UA should be targeted below 6.0 mg/dL to inhibit the progression towards end-stage renal disease. Underlying mechanisms whereby an increase in serum UA induces kidney injury have been elucidated in animal models. Hyperuricemic models can lead to systemic hypertension, arteriolosclerosis including afferent arteriolopathy as well as albuminuria probably due to the activation of oxidative stress. Discoveries of urate transporters have elucidated the novel mechanism of UA transport in the kidney and intestine. The intestinal ABCG2 may play a compensatory role in light of decreased renal clearance of UA in CKD model rats, the trigger of which is not a uremic toxin but serum UA itself. Insulin directly upregulates URAT1 and downregulates ABCG2 in the kidney tubules, suggesting a possible link between UA and metabolic syndrome. This review summarizes the recent knowledge on the causal effect of serum UA on the kidney injury. (c) 2018 S. Karger AG, Basel
C1 [Uchida, Shunya; Kumagai, Takanori; Tamura, Yoshifuru; Shibata, Shigeru] Teikyo Univ, Sch Med, Dept Internal Med, Tokyo, Japan.
   [Kumagai, Takanori] Teikyo Univ, Sch Med, Support Community Med Endowed Chair, Tokyo, Japan.
   [Chang, Wen Xiu] Tianjin First Ctr Hosp, Dept Nephrol, Tianjin, Peoples R China.
C3 Teikyo University; Teikyo University
RP Uchida, S (corresponding author), Teikyo Univ, Sch Med, Dept Internal Med, Itabashi Ku, 2-11-1 Kaga, Tokyo 1738605, Japan.
EM s_uchida@netjoy.ne.jp
OI Shibata, Shigeru/0000-0002-6868-0626; , wen xiu/0000-0001-6269-5694
CR Bose B, 2014, NEPHROL DIAL TRANSPL, V29, P406, DOI 10.1093/ndt/gft378
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NR 36
TC 13
Z9 15
U1 0
U2 14
PU KARGER
PI BASEL
PA POSTFACH, CH-4009 BASEL, SWITZERLAND
SN 0302-5144
EI 1662-2782
BN 978-3-318-06251-9; 978-3-318-06250-2
J9 CONTRIB NEPHROL
JI Contrib.Nephrol.
PY 2018
VL 192
BP 56
EP 68
DI 10.1159/000484279
D2 10.1159/isbn.978-3-318-06251-9
PG 13
WC Urology & Nephrology
WE Book Citation Index – Science (BKCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA BK3ON
UT WOS:000435332200010
PM 29393121
DA 2025-06-11
ER

PT J
AU Di Lisa, F
   Giorgio, M
   Ferdinandy, P
   Schulz, R
AF Di Lisa, Fabio
   Giorgio, Marco
   Ferdinandy, Peter
   Schulz, Rainer
TI New aspects of p66Shc in ischaemia reperfusion injury and other
   cardiovascular diseases
SO BRITISH JOURNAL OF PHARMACOLOGY
LA English
DT Review
ID PERIPHERAL-BLOOD MONOCYTES; KINASE-C-BETA; ENDOTHELIAL-CELL DYSFUNCTION;
   P66(SHC) GENE-EXPRESSION; ADAPTER PROTEIN P66(SHC);
   CORONARY-ARTERY-DISEASE; OXIDATIVE STRESS; MITOCHONDRIAL DYSFUNCTION;
   LIFE-SPAN; CONCISE GUIDE
AB Although reactive oxygen species (ROS) act as crucial factors in the onset and progression of a wide array of diseases, they are also involved in numerous signalling pathways related to cell metabolism, growth and survival. ROS are produced at various cellular sites, and it is generally agreed that mitochondria generate the largest amount, especially those in cardiomyocytes. However, the identification of the most relevant sites within mitochondria, the interaction among the various sources, and the events responsible for the increase in ROS formation under pathological conditions are still highly debated, and far from being clarified. Here, we review the information linking the adaptor protein p66Shc with cardiac injury induced by ischaemia and reperfusion (I/R), including the contribution of risk factors, such as metabolic syndrome and ageing. In response to several stimuli, p66Shc migrates into mitochondria where it catalyses electron transfer from cytochrome c to oxygen resulting in hydrogen peroxide formation. Deletion of p66Shc has been shown to reduce I/R injury as well as vascular abnormalities associated with diabetes and ageing. However, p66Shc-induced ROS formation is also involved in insulin signalling and might contribute to self-endogenous defenses against mild I/R injury. In addition to its role in physiological and pathological conditions, we discuss compounds and conditions that can modulate the expression and activity of p66Shc.
C1 [Di Lisa, Fabio] Univ Padua, Dept Biomed Sci, Viale Ugo Bassi 58-B, I-35131 Padua, Italy.
   [Di Lisa, Fabio] Univ Padua, CNR Neurosci Inst, Viale Ugo Bassi 58-B, I-35131 Padua, Italy.
   [Giorgio, Marco] Inst Oncol, Dept Expt Oncol, Milan, Italy.
   [Ferdinandy, Peter] Semmelweis Univ, Dept Pharmacol & Pharmacotherapy, Budapest, Hungary.
   [Ferdinandy, Peter] Pharmahungary Grp, Szeged, Hungary.
   [Schulz, Rainer] Justus Liebig Univ Giessen, Inst Physiol, Giessen, Germany.
C3 University of Padua; University of Padua; Consiglio Nazionale delle
   Ricerche (CNR); Semmelweis University; Pharmahungary Group; Justus
   Liebig University Giessen
RP Di Lisa, F (corresponding author), Univ Padua, Dept Biomed Sci, Viale Ugo Bassi 58-B, I-35131 Padua, Italy.; Di Lisa, F (corresponding author), Univ Padua, CNR Neurosci Inst, Viale Ugo Bassi 58-B, I-35131 Padua, Italy.
EM fabio.dilisa@gmail.com
RI Ferdinandy, Péter/H-9181-2019; Giorgio, Marco/I-9425-2012; Schulz,
   Rainer/ABD-5069-2021
OI Schulz, Rainer/0000-0003-3017-0476
FU German Research Foundations [Schu 843/9-1]; CARIPARO Foundation
   (Progetti di Eccellenza); Progetto Strategico "Dycendi" of the
   University of Padova; European Foundation for the Study of Diabetes;
   Hungarian Scientific Research Fund [OTKA K 109737, OTKA ANN 107803]
FX R. S. received grants from the German Research Foundations (Schu
   843/9-1). The work in F D L's laboratory is supported by CARIPARO
   Foundation (Progetti di Eccellenza) and Progetto Strategico "Dycendi" of
   the University of Padova. Peter Ferdinandy and R. S. received a
   collaborative grant from the European Foundation for the Study of
   Diabetes. P. F. received grants from the Hungarian Scientific Research
   Fund (OTKA K 109737 and OTKA ANN 107803). The MS was elaborated in the
   scope of the European COST EU-ROS network (BM1203).
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NR 125
TC 56
Z9 57
U1 0
U2 17
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0007-1188
EI 1476-5381
J9 BRIT J PHARMACOL
JI Br. J. Pharmacol.
PD JUN
PY 2017
VL 174
IS 12
SI SI
BP 1690
EP 1703
DI 10.1111/bph.13478
PG 14
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA EV9YH
UT WOS:000402143300011
PM 26990284
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Slim, KE
   Vauzour, D
   Tejera, N
   Voshol, PJ
   Cassidy, A
   Minihane, AM
AF Slim, Kenna E.
   Vauzour, David
   Tejera, Noemi
   Voshol, Peter J.
   Cassidy, Aedin
   Minihane, Anne Marie
TI The effect of dietary fish oil on weight gain and insulin sensitivity is
   dependent on APOE genotype in humanized targeted replacement mice
SO FASEB JOURNAL
LA English
DT Article
DE diabetes; glucose; Glut4; IL-10; IPGTT
ID CORONARY-HEART-DISEASE; APOLIPOPROTEIN-E POLYMORPHISM;
   ENDOPLASMIC-RETICULUM STRESS; POLYUNSATURATED FATTY-ACIDS;
   ADIPOSE-TISSUE; E GENE; GLUCOSE-TRANSPORTER; METABOLIC SYNDROME;
   BODY-COMPOSITION; SKELETAL-MUSCLE
AB We investigated the independent and interactive impact of the common APOE genotype and marine n-3 polyunsaturated fatty acids (PUFAs) on the development of obesity and associated cardiometabolic dysfunction in a murine model. Human APOE3 and APOE4 targeted replacement mice were fed either a control high-fat diet (HFD) or an HFD supplemented with 3% n-3 PUFAs from fish oil (HFD + FO) for 8 wk. We established the impact of intervention on food intake, body weight, and visceral adipose tissue (VAT) mass; plasma, lipids (cholesterol and triglycerides), liver enzymes, and adipokines; glucose and insulin during an intraperitoneal glucose tolerance test; and Glut4 and ApoE expression in VAT. HFD feeding induced more weight gain and higher plasma lipids in APOE3 compared to APOE4 mice (P < 0.05), along with a 2-fold higher insulin and impaired glucose tolerance. Supplementing APOE3, but not APOE4, animals with dietary n-3 PUFAs decreased body-weight gain, plasma lipids, and insulin (P < 0.05) and improved glucose tolerance, which was associated with increased VAT Glut4 mRNA levels (P< 0.05). Our findings demonstrate that an APOE3 genotype predisposes mice to develop obesity and its metabolic complications, which was attenuated by n-3 PUFA supplementation.
C1 [Slim, Kenna E.; Vauzour, David; Tejera, Noemi; Cassidy, Aedin; Minihane, Anne Marie] Univ East Anglia, Norwich Med Sch, Dept Nutr & Prevent Med, Norwich NR4 7UQ, Norfolk, England.
   [Voshol, Peter J.] Louis Bolk Inst, Dept Nutr & Hlth, Driebergen, Netherlands.
   [Voshol, Peter J.] Univ Cambridge, Inst Metab Sci, Cambridge, England.
C3 University of East Anglia; University of Cambridge
RP Minihane, AM (corresponding author), Univ East Anglia, Norwich Med Sch, Dept Nutr & Prevent Med, Norwich NR4 7UQ, Norfolk, England.
EM a.minihane@uea.ac.uk
RI Tejera, Noemi/O-1558-2016; VAUZOUR, David/C-2245-2008
OI VAUZOUR, David/0000-0001-5952-8756; Tejera, Noemi/0000-0001-8100-6022
FU University of East Anglia Faculty of Medicine and Health Sciences
   Graduate School studentship; Biotechnology and Biological Sciences
   Research Council Institute Strategic Program grant [BB/J004545/1]; BBSRC
   [BB/M004449/1] Funding Source: UKRI
FX This project was funded by a University of East Anglia Faculty of
   Medicine and Health Sciences Graduate School studentship and a
   Biotechnology and Biological Sciences Research Council Institute
   Strategic Program grant (BB/ J004545/1).
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NR 56
TC 13
Z9 15
U1 0
U2 12
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
EI 1530-6860
J9 FASEB J
JI Faseb J.
PD MAR
PY 2017
VL 31
IS 3
BP 989
EP 997
DI 10.1096/fj.201600921RR
PG 9
WC Biochemistry & Molecular Biology; Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA EM9ZX
UT WOS:000395671200015
PM 27895108
OA Green Published, hybrid, Green Accepted
DA 2025-06-11
ER

PT J
AU Mazidi, M
   Rezaie, P
   Ferns, GA
   Vatanparast, H
AF Mazidi, Mohsen
   Rezaie, Peyman
   Ferns, Gordon A.
   Vatanparast, Hassan
TI Impact of Probiotic Administration on Serum C-Reactive Protein
   Concentrations: Systematic Review and Meta-Analysis of Randomized
   Control Trials
SO NUTRIENTS
LA English
DT Review
DE meta-analysis; probiotic; C-reactive protein
ID METABOLIC SYNDROME; DOUBLE-BLIND; HS-CRP; INFLAMMATORY MARKERS;
   OXIDATIVE STRESS; LIPID PROFILE; DIETARY SUPPLEMENTATION;
   SACCHAROMYCES-BOULARDII; RHEUMATOID-ARTHRITIS; INSULIN-RESISTANCE
AB We conducted this systematic review and meta-analysis of prospective studies to determine the effect of probiotic administration on serum C-reactive protein (CRP) concentrations. We searched PubMed-Medline, Web of Science, the Cochrane, and Google Scholar databases (until May 2016) to identify prospective studies evaluating the impact of probiotic administration on CRP. We used a random effects models and generic inverse variance methods to synthesize quantitative data, followed by a leave-one-out method for sensitivity analysis. The systematic review registration number was: CRD42016039457. From a total of 425 entries identified via searches, 20 studies were included in the final analysis. The meta-analysis indicated a significant reduction in serum CRP following probiotic administration with a weighted mean difference (WMD) of -1.35 mg/L, (95% confidence interval (CI) -2.15 to -0.55, I-2 65.1%). The WMDs for interleukin 10 (IL10) was -1.65 pg/dL, (95% CI -3.45 to 0.14, I-2 3.1%), and -0.45 pg/mL, (95% CI -1.38 to 0.48, I-2 10.2%) for tumor necrosis factor alpha (TNF-alpha). These findings were robust in sensitivity analyses. This meta-analysis suggests that probiotic administration may significantly reduce serum CRP while having no significant effect on serum IL10 and TNF-alpha.
C1 [Mazidi, Mohsen] Chinese Acad Sci, Inst Genet & Dev Biol, Key State Lab Mol Dev Biol, Beijing 100101, Peoples R China.
   [Mazidi, Mohsen] Univ Chinese Acad Sci, Int Coll, Inst Genet & Dev Biol, Beijing 100101, Peoples R China.
   [Rezaie, Peyman] Mashhad Univ Med Sci, Sch Med, Biochem & Nutr Res Ctr, Mashhad 42536, Iran.
   [Ferns, Gordon A.] Univ Brighton, Brighton & Sussex Med Sch, Div Med Educ, Rm 342,Mayfield House, Brighton BN1 9PH, E Sussex, England.
   [Vatanparast, Hassan] Univ Saskatchewan, Coll Pharm & Nutr, Hlth Sci E Wing, 104 Clin Pl, Saskatoon, SK S7N 2Z4, Canada.
C3 Chinese Academy of Sciences; Institute of Genetics & Developmental
   Biology, CAS; Chinese Academy of Sciences; Institute of Genetics &
   Developmental Biology, CAS; University of Chinese Academy of Sciences,
   CAS; Mashhad University of Medical Sciences; University of Brighton;
   University of Sussex; University of Saskatchewan
RP Vatanparast, H (corresponding author), Univ Saskatchewan, Coll Pharm & Nutr, Hlth Sci E Wing, 104 Clin Pl, Saskatoon, SK S7N 2Z4, Canada.
EM moshen@genetics.ac.cn; peymanrezaie.nutrition@gmail.com;
   s.brown5@brighton.ac.uk; vatan.h@usask.ca
RI Linn, Shai/N-3079-2019; Rezaie, Peyman/GMX-3967-2022
FU Chinese Academy of Sciences
FX M.M. was supported by a TWAS studentship of the Chinese Academy of
   Sciences, during the preparation of this manuscript.
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NR 68
TC 67
Z9 68
U1 0
U2 8
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JAN
PY 2017
VL 9
IS 1
AR 20
DI 10.3390/nu9010020
PG 14
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA EO1NP
UT WOS:000396465500020
PM 28054937
OA Green Published, gold, Green Accepted, Green Submitted
DA 2025-06-11
ER

PT J
AU Adamu, HA
   Imam, MU
   Ooi, DJ
   Esa, NM
   Rosli, R
   Ismail, M
AF Adamu, Hadiza Altine
   Imam, Mustapha Umar
   Ooi, Der-Jiun
   Esa, Norhaizan Mohd
   Rosli, Rozita
   Ismail, Maznah
TI Perinatal exposure to germinated brown rice and its gamma amino-butyric
   acid-rich extract prevents high fat diet-induced insulin resistance in
   first generation rat offspring
SO FOOD & NUTRITION RESEARCH
LA English
DT Article
DE epigenetics; germinated rice bran; gamma amino-butyric acid; insulin
   resistance
ID BINDING-PROTEIN 4; METABOLIC SYNDROME; OBESITY; RISK; ASSOCIATION;
   ADIPOSITY
AB Background: Evidence suggests perinatal environments influence the risk of developing insulin resistance.
   Objective: The present study was aimed at determining the effects of intrauterine exposure to germinated brown rice (GBR) and GBR-derived gamma (g) aminobutyric acid (GABA) extract on epigenetically mediated high fat diet-induced insulin resistance.
   Design: Pregnant Sprague Dawley rats were fed high-fat diet (HFD), HFD + GBR, or HFD + GABA throughout pregnancy until 4 weeks postdelivery. The pups were weighed weekly and maintained on normal pellet until 8 weeks postdelivery. After sacrifice, biochemical markers of obesity and insulin resistance including oral glucose tolerance test, adiponectin, leptin, and retinol binding protein-4 (RBP4) were measured. Hepatic gene expression changes and the global methylation and histone acetylation levels were also evaluated.
   Results: Detailed analyses revealed that mothers given GBR and GABA extract, and their offspring had increased adiponectin levels and reduced insulin, homeostasis model assessment of insulin resistance, leptin, oxidative stress, and RBP4 levels, while their hepatic mRNA levels of GLUT2 and IPF1 were increased. Furthermore, GBR and GABA extract lowered global DNA methylation levels and modulated H3 and H4 acetylation levels.
   Conclusions: These results showed that intrauterine exposure to GBR-influenced metabolic outcomes in offspring of rats with underlying epigenetic changes and transcriptional implications that led to improved glucose homeostasis.
C1 [Adamu, Hadiza Altine; Imam, Mustapha Umar; Ooi, Der-Jiun; Ismail, Maznah] Univ Putra Malaysia, Inst Biosci, Lab Mol Biomed, Serdang 43400, Selangor, Malaysia.
   [Esa, Norhaizan Mohd; Ismail, Maznah] Univ Putra Malaysia, Dept Nutr & Dietet, Serdang 43400, Selangor, Malaysia.
   [Rosli, Rozita] Univ Pra Malaysia, Inst Biosci, UPM MAKNA Canc Res Lab, Serdang, Selangor, Malaysia.
C3 Universiti Putra Malaysia; Universiti Putra Malaysia; Universiti Putra
   Malaysia
RP Imam, MU; Ismail, M (corresponding author), Univ Putra Malaysia, Inst Biosci, Lab Mol Biomed, Serdang 43400, Selangor, Malaysia.
EM mustyimam@gmail.com; maznahis@upm.edu.my
RI Mohd.-Esa, Norhaizan/ABA-2783-2021; Imam, Mustapha/K-3490-2012; Ooi, Der
   Jiun/N-3801-2014
OI Imam, Mustapha Umar/0000-0001-9888-4809; ISMAIL,
   MAZNAH/0000-0002-2378-0519; Ooi, Der Jiun/0000-0002-4896-2351
FU PadiBeras Nasional Berhad; Universiti Putra Malaysia [63536]
FX This study was supported by grants from PadiBeras Nasional Berhad and
   Universiti Putra Malaysia (vote no 63536). The authors thank the staff
   of the Laboratory of Molecular Biomedicine for their assistance with
   this study.
CR Aguiree F, 2013, INT DIABETES FEDERAT, P29
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   Imam MU, 2014, J FUNCT FOODS, V8, P193, DOI 10.1016/j.jff.2014.03.013
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NR 32
TC 12
Z9 13
U1 0
U2 21
PU SWEDISH NUTRITION FOUNDATION-SNF
PI LUND
PA IDEON SCIENCE PARK, BESOK SCHEELEV 17 BETA 5, 3V, LUND, 223 70, SWEDEN
SN 1654-6628
EI 1654-661X
J9 FOOD NUTR RES
JI Food Nutr. Res.
PY 2016
VL 60
AR 30209
DI 10.3402/fnr.v60.30209
PG 10
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA DC4IC
UT WOS:000369183300001
PM 26842399
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Mure, K
   Yoshimura, N
   Hashimoto, M
   Muraki, S
   Oka, H
   Tanaka, S
   Kawaguchi, H
   Nakamura, K
   Akune, T
   Takeshita, T
AF Mure, Kanae
   Yoshimura, Noriko
   Hashimoto, Marowa
   Muraki, Shigeyuki
   Oka, Hiroyuki
   Tanaka, Sakae
   Kawaguchi, Hiroshi
   Nakamura, Kozo
   Akune, Toru
   Takeshita, Tatsuya
TI Urinary 8-iso-prostaglandin F2 as a marker of metabolic risks in the
   general Japanese population: The ROAD study
SO OBESITY
LA English
DT Article
ID SYSTEMIC OXIDATIVE STRESS; LOW-DENSITY-LIPOPROTEIN; IN-VIVO;
   F-2-ISOPROSTANES; ISOPROSTANES; ACCUMULATION; HEMOGLOBIN; OVERWEIGHT;
   BIOMARKERS; ADIPOSITY
AB ObjectiveTo determine whether 8-iso-prostaglandin F2 (8-iso-PGF2) is a reliable biomarker of the accumulation of metabolic risks [e.g., overweight, hypertension, impaired glucose tolerance (IGT), and dyslipidemia].
   MethodsThis was a cross-sectional study of the baseline characteristics of a Japanese general population cohort study: Research on Osteoarthritis/Osteoporosis Against Disability (ROAD). Of 1,690 participants, 1,527 fulfilled all questionnaires and examinations. Free and conjugated urinary 8-iso-PGF2 levels and metabolic syndrome (MetS) components including blood pressure, HbA1c, total cholesterol, high-density lipoprotein cholesterol (HDL-C), and non-HDL-C were analyzed. The data were analyzed by ANCOVA, multiple regression analysis, and multinomial logistic analysis.
   Results8-iso-PGF2 was significantly associated with HbA1c and significantly inversely associated with total cholesterol and non-HDL-C. Notably, IGT with an HbA1c cut-off of 5.5% was significantly associated with 8-iso-PGF2 level in participants aged 50 years. Multinomial logistic regression analysis revealed 8-iso-PGF2 level was significantly associated with a greater number of MetS risks present; this association was stronger in younger participants. In participants aged 71 years, 8-iso-PGF2 was significantly associated with a greater number of MetS risks with higher IGT cut-offs.
   ConclusionsUrinary 8-iso-PGF2 can be a reliable marker of IGT and the accumulation of MetS risks, especially in younger people.
C1 [Mure, Kanae; Hashimoto, Marowa; Takeshita, Tatsuya] Wakayama Med Univ, Sch Med, Dept Publ Hlth, Wakayama, Japan.
   [Yoshimura, Noriko; Oka, Hiroyuki] Univ Tokyo, Grad Sch Med, 22nd Century Med & Res Ctr, Dept Joint Dis Res, Tokyo, Japan.
   [Muraki, Shigeyuki] Univ Tokyo, Grad Sch Med, Dept Clin Motor Syst Med, 22nd Century Med & Res Ctr, Tokyo, Japan.
   [Tanaka, Sakae] Univ Tokyo, Fac Med, Dept Orthopaed Surg, Tokyo 113, Japan.
   [Kawaguchi, Hiroshi] JCHO Tokyo Shinjuku Med Ctr, Tokyo, Japan.
   [Nakamura, Kozo; Akune, Toru] Natl Rehabil Ctr Persons Disabil, Saitama, Japan.
C3 Wakayama Medical University; University of Tokyo; University of Tokyo;
   University of Tokyo
RP Mure, K (corresponding author), Wakayama Med Univ, Sch Med, Dept Publ Hlth, Wakayama, Japan.
EM kana@wakayama-med.ac.jp
RI Tanaka, Sakae/Y-3061-2019
OI Tanaka, Sakae/0000-0001-9210-9414
FU Ministry of Education, Culture, Sports, Science, and Technology of Japan
   [B26293139, B23390172, B20390182, 24659317, C20591737, B23390357,
   C20591774, B23390356, 23659580, A18689031, 24659666]; Ministry of
   Health, Labour, and Welfare of Japan [H17-Men-eki-009, H18-Cho-ju-037,
   H20-Cho-ju-009, H23-Cho-ju-002, H25-Nanchi-to (Men)-005,
   H25-Cho-ju-007]; Japan Osteoporosis Society; Japanese Orthopaedic
   Association (JOA) [2006-1, 2010-2]; National Science Foundation from the
   Ministry of Education, Culture, Sports, Science, and Technology of Japan
   [08033011-00262]; Grants-in-Aid for Scientific Research [23659580,
   25670301, 24659317, 25670293, 26670307, 25460811, 15H04787, 26293329,
   24659666] Funding Source: KAKEN
FX This work was supported by Grants-in-Aid for Scientific Research to NY
   (B26293139, B23390172, B20390182, and Challenging Exploratory Research
   24659317), TA (C20591737, B23390357), and SM (C20591774, B23390356, and
   Challenging Exploratory Research 23659580); for Young Scientists to HO
   (A18689031 and Challenging Exploratory Research 24659666); and for
   Collaborating Research with the National Science Foundation to NY
   (Director; 08033011-00262) from the Ministry of Education, Culture,
   Sports, Science, and Technology of Japan as well as H17-Men-eki-009
   (Director, KN), H18-Cho-ju-037 (Director, TN), H20-Cho-ju-009 (Director,
   NY), H23-Cho-ju-002 (Director, TA), H25-Nanchi-to (Men)-005 (Director,
   ST), and H25-Cho-ju-007 (Director, NY) from the Ministry of Health,
   Labour, and Welfare of Japan. This study was also supported by grants
   from the Japan Osteoporosis Society (NY, SM, HO, and TA) and by research
   aid from the Japanese Orthopaedic Association (JOA-Subsidized Science
   Project Research 2006-1 and 2010-2; Director, HK).
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NR 40
TC 19
Z9 19
U1 0
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1930-7381
EI 1930-739X
J9 OBESITY
JI Obesity
PD JUL
PY 2015
VL 23
IS 7
BP 1517
EP 1524
DI 10.1002/oby.21130
PG 8
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA CL4AD
UT WOS:000356893400026
PM 26054643
OA Bronze
DA 2025-06-11
ER

PT J
AU Rubio-Ruiz, ME
   Pérez-Torres, I
   Soto, ME
   Pastelín, G
   Guarner-Lans, V
AF Esther Rubio-Ruiz, Maria
   Perez-Torres, Israel
   Elena Soto, Maria
   Pastelin, Gustavo
   Guarner-Lans, Veronica
TI Aging in blood vessels. Medicinal agents FOR systemic arterial
   hypertension in the elderly
SO AGEING RESEARCH REVIEWS
LA English
DT Review
DE Aging; Endothelial cells; Hypertension; Medicinal agents
ID RENIN-ANGIOTENSIN SYSTEM; VASCULAR ENDOTHELIAL DYSFUNCTION;
   ANTIHYPERTENSIVE DRUG-TREATMENT; CHRONIC KIDNEY-DISEASE; NITRIC-OXIDE
   SYNTHASE; CARDIOVASCULAR RISK; HYPERPOLARIZING FACTOR;
   INSULIN-RESISTANCE; PRIMARY PREVENTION; METABOLIC SYNDROME
AB Aging impairs blood vessel function and leads to cardiovascular disease. The mechanisms underlying the age-related endothelial, smooth muscle and extracellular matrix vascular dysfunction are discussed. Vascular dysfunction is caused by: (1) Oxidative stress enhancement. (2) Reduction of nitric oxide (NO) bioavailability, by diminished NO synthesis and/or augmented NO scavenging. (3) Production of vasoconstrictor/vasodilator factor imbalances. (4) Low-grade pro-inflammatory environment. (5) Impaired angiogenesis. (6) Endothelial cell senescence. The aging process in vascular smooth muscle is characterized by: (1) Altered replicating potential. (2) Change in cellular phenotype. (3) Changes in responsiveness to contracting and relaxing mediators. (4) Changes in intracellular signaling functions.
   Systemic arterial hypertension is an age-dependent disorder, and almost half of the elderly human population is hypertensive. The influence of hypertension on the aging cardiovascular system has been studied in models of hypertensive rats. Treatment for hypertension is recommended in the elderly. Lifestyle modifications, natural compounds and hormone therapies are useful for initial stages and as supporting treatment with medication but evidence from clinical trials in this population is needed. Since all antihypertensive agents can lower blood pressure in the elderly, therapy should be based on its potential side effects and drug interactions. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Esther Rubio-Ruiz, Maria; Guarner-Lans, Veronica] Inst Nacl Cardiol Ignacio Chavez, Dept Fisiol, Mexico City 14080, DF, Mexico.
   [Perez-Torres, Israel] Inst Nacl Cardiol Ignacio Chavez, Dept Pathol, Mexico City 14080, DF, Mexico.
   [Elena Soto, Maria] Inst Nacl Cardiol Ignacio Chavez, Dept Immunol, Mexico City 14080, DF, Mexico.
   [Pastelin, Gustavo] Inst Nacl Cardiol Ignacio Chavez, Dept Pharmacol, Mexico City 14080, DF, Mexico.
C3 National Institute of Cardiology - Mexico; National Institute of
   Cardiology - Mexico; National Institute of Cardiology - Mexico; National
   Institute of Cardiology - Mexico
RP Guarner-Lans, V (corresponding author), Inst Nacl Cardiol Ignacio Chavez, Dept Fisiol, Juan Badiano 1, Mexico City 14080, DF, Mexico.
EM gualanv@yahoo.com
RI Pérez Torres, Israel/AAE-2579-2022; Guarner-Lans, Verónica/AFW-3723-2022
OI Perez-Torres, Israel/0000-0001-6510-2954; Rubio-Ruiz, Maria
   Esther/0000-0002-8844-2078; Guarner-Lans, Veronica/0000-0002-2655-7590;
   Soto, Maria Elena/0000-0003-1332-2888
CR [Anonymous], 2014, Georgian Med News, P33
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NR 179
TC 61
Z9 70
U1 0
U2 22
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 1568-1637
EI 1872-9649
J9 AGEING RES REV
JI Ageing Res. Rev.
PD NOV
PY 2014
VL 18
BP 132
EP 147
DI 10.1016/j.arr.2014.10.001
PG 16
WC Cell Biology; Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Geriatrics & Gerontology
GA AY7XK
UT WOS:000347769000011
PM 25311590
DA 2025-06-11
ER

PT J
AU Adinolfi, LE
   Zampino, R
   Restivo, L
   Lonardo, A
   Guerrera, B
   Marrone, A
   Nascimbeni, F
   Florio, A
   Loria, P
AF Adinolfi, Luigi E.
   Zampino, Rosa
   Restivo, Luciano
   Lonardo, Amedeo
   Guerrera, Barbara
   Marrone, Aldo
   Nascimbeni, Fabio
   Florio, Anna
   Loria, Paola
TI Chronic hepatitis C virus infection and atherosclerosis: Clinical impact
   and mechanisms
SO WORLD JOURNAL OF GASTROENTEROLOGY
LA English
DT Article
DE Hepatitis C virus; Atherosclerosis; Coronary artery disease; Stroke;
   Inflammation
ID LIVER-RELATED MORTALITY; POPULATION-BASED COHORT; CHRONIC HCV INFECTION;
   SUBCLINICAL ATHEROSCLEROSIS; CAROTID ATHEROSCLEROSIS;
   MYOCARDIAL-INFARCTION; INSULIN-RESISTANCE; RISK-FACTORS; ALL-CAUSE;
   ASSOCIATION
AB Hepatitis C virus (HCV) infection represents a major health issue worldwide due to its burden of chronic liver disease and extrahepatic manifestations including cardiovascular diseases, which are associated with excess mortality. Analysis of published studies supports the view that HCV infection should be considered a risk factor for the development of carotid atherosclerosis, heart failure and stroke. In contrast, findings from studies addressing coronary artery disease and HCV have yielded conflicting results. Therefore, meta-analytic reviews and prospective studies are warranted. The pathogenic mechanisms connecting HCV infection, chronic liver disease, and atherogenesis are not completely understood. However, it has been hypothesized that HCV may promote atherogenesis and its complications through several direct and indirect biological mechanisms involving HCV colonization and replication within arterial walls, liver steatosis and fibrosis, enhanced and imbalanced secretion of inflammatory cytokines, oxidative stress, endotoxemia, mixed cryoglobulinemia, perturbed cellular and humoral immunity, hyperhomocysteinemia, hypo-adiponectinaemia, insulin resistance, type 2 diabetes and other components of the metabolic syndrome. Understanding these complex mechanisms is of fundamental importance for the development of novel therapeutic approaches to prevent and to treat vascular complications in patients with chronic HCV infection. Currently, it seems that HCV clearance by interferon and ribavirin treatment significantly reduces non-liver-related mortality; moreover, interferon-based treatment appears to decrease the risk of ischemic stroke.
C1 [Adinolfi, Luigi E.; Zampino, Rosa; Restivo, Luciano; Guerrera, Barbara; Marrone, Aldo] Univ Naples 2, Dept Med Surg Neurol Metab & Geriatr Sci, I-80100 Naples, Italy.
   [Lonardo, Amedeo; Nascimbeni, Fabio; Loria, Paola] Univ Modena & Reggio Emilia, Dept Internal Med Endocrinol Metab & Geriatr, I-41126 Modena, Italy.
   [Florio, Anna] Univ Naples 2, I-80100 Naples, Italy.
C3 Universita di Modena e Reggio Emilia; Universita della Campania
   Vanvitelli
RP Adinolfi, LE (corresponding author), Univ Naples 2, Dept Med Surg Neurol Metab & Geriatr Sci, I-80100 Naples, Italy.
EM luigielio.adinolfi@unina2.it
RI Marrone, Aldo/AAH-3614-2020; Lonardo, Amedeo/I-5911-2019
OI ZAMPINO, Rosa/0000-0003-2804-186X; Nascimbeni,
   Fabio/0000-0002-1051-1272; Lonardo, Amedeo/0000-0001-9886-0698; FLORIO,
   Anna/0000-0002-0879-5640; , Anna Florio/0000-0002-5305-733X; MARRONE,
   Aldo/0000-0001-7329-4159
FU Regione Campania, Italy
FX Supported by A grant by Regione Campania, Italy
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NR 50
TC 135
Z9 142
U1 2
U2 11
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 8226 REGENCY DR, PLEASANTON, CA 94588 USA
SN 1007-9327
EI 2219-2840
J9 WORLD J GASTROENTERO
JI World J. Gastroenterol.
PD APR 7
PY 2014
VL 20
IS 13
BP 3410
EP 3417
DI 10.3748/wjg.v20.i13.3410
PG 8
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA AF0SC
UT WOS:000334423300003
PM 24707124
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Jung, CH
   Lee, WJ
   Hwang, JY
   Seol, SM
   Kim, YM
   Lee, YL
   Park, JY
AF Jung, Chang Hee
   Lee, Woo Je
   Hwang, Jenie Yoonoo
   Seol, So Mi
   Kim, Yun Mi
   Lee, Yoo La
   Park, Joong-Yeol
TI Vaspin protects vascular endothelial cells against free fatty
   acid-induced apoptosis through a phosphatidylinositol 3-kinase/Akt
   pathway
SO BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
LA English
DT Article
DE Vaspin; Endothelial cells; Apoptosis; Phosphatidylinositol 3-kinase; Akt
ID INSULIN-RESISTANCE; NITRIC-OXIDE; LINOLEIC-ACID; METABOLIC SYNDROME;
   OXIDATIVE STRESS; ADIPOSE-TISSUE; GROWTH-FACTOR; AKT; EXPRESSION;
   SURVIVAL
AB Vaspin, an adipocytokine recently identified in a rat model of type 2 diabetes, has been suggested to have an insulin-sensitizing effect. However, the exact mechanism underlying this action has not been fully elucidated. Furthermore, the specific function of vaspin is largely unknown, especially in vascular cells. We examined whether vaspin affects the insulin-signaling pathway in cultured endothelial cells and is capable of preventing free fatty acid (FFA)-induced apoptosis in endothelial cells through its insulin sensitizing effect, specifically, through its stimulatory effect on PI3-kinase/Akt signaling pathways. Vaspin significantly increased Akt phosphorylation and prevented the impairment of Akt phosphorylation by linoleic acid (LA) in insulin-stimulated endothelial cells, which effects were abolished by pretreatment with the PI3-kinase inhibitor, Wortmannin. Moreover, pretreatment with vaspin prevented LA-induced apoptosis in insulin-stimulated endothelial cells; this anti-apoptotic effect of vaspin was also eliminated by pretreatment with Wortmannin. The present study indicates that vaspin protects vascular endothelial cells from FFA-induced apoptosis through upregulation of the PI3-kinase/Akt signaling pathway. Our study is the first to demonstrate that vascular cells can be targets of vaspin. Our results further suggest that vaspin could have beneficial effects on the atherosclerosis. (C) 2011 Elsevier Inc. All rights reserved.
C1 [Jung, Chang Hee; Lee, Woo Je; Hwang, Jenie Yoonoo; Park, Joong-Yeol] Univ Ulsan, Coll Med, Dept Internal Med, Seoul 138736, South Korea.
   [Seol, So Mi; Kim, Yun Mi; Lee, Yoo La] Univ Ulsan, Coll Med, Asan Inst Life Sci, Seoul 138736, South Korea.
C3 University of Ulsan; University of Ulsan
RP Park, JY (corresponding author), Univ Ulsan, Coll Med, Dept Internal Med, Seoul 138736, South Korea.
EM jypark@amc.seoul.kr
RI Jung, Chang/AAU-7897-2020; Jeong, Young-Hoon/F-3476-2015; Park,
   Jun/HPH-3570-2023; Lee, Sang-Jun/A-3892-2015
OI Jung, Chang Hee/0000-0003-4043-2396
FU Asan Institute of Life Sciences, Republic of Korea [2010-122, 2010-485]
FX This work was supported by Grants (2010-122, 2010-485) from the Asan
   Institute of Life Sciences, Republic of Korea.
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NR 39
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Z9 91
U1 0
U2 7
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0006-291X
EI 1090-2104
J9 BIOCHEM BIOPH RES CO
JI Biochem. Biophys. Res. Commun.
PD SEP 23
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VL 413
IS 2
BP 264
EP 269
DI 10.1016/j.bbrc.2011.08.083
PG 6
WC Biochemistry & Molecular Biology; Biophysics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics
GA 827QQ
UT WOS:000295443400020
PM 21893030
DA 2025-06-11
ER

PT J
AU Hwang, SJ
   Lee, SD
AF Hwang, Shinn-Jang
   Lee, Shou-Dong
TI Hepatic steatosis and hepatitis C: Still unhappy bedfellows?
SO JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
LA English
DT Review
DE hepatitis C; genotype; hepatitis steatosis; Insulin resistance; diabetes
   mellitus; liver fibrosis; hepatocellular carcinoma
ID FATTY LIVER-DISEASE; VIRUS CORE PROTEIN; GAMMA-GLUTAMYL-TRANSPEPTIDASE;
   INDUCED INSULIN-RESISTANCE; ACTIVATED-RECEPTOR-ALPHA;
   HEPATOCELLULAR-CARCINOMA; DIABETES-MELLITUS; OXIDATIVE STRESS;
   TRANSGENIC MICE; PEROXISOME-PROLIFERATOR
AB Hepatic steatosis is commonly seen in patients with chronic hepatitis C virus (HCV) infection, and the prevalence is much higher prevalence than in the general population or in patients with chronic hepatitis B. Hepatic steatosis in patients with chronic hepatitis C can be due to alcohol consumption and host metabolic factors such as high body mass index (BMI), obesity, hyperlipidemia, metabolic syndrome and diabetes mellitus in which insulin resistance plays an important role. However, in genotype 3 HCV infection, hepatic steatosis can result from direct viral cytopathic effect. Demographic and clinical characteristics associated with hepatic steatosis in patients with chronic hepatitis C including older age, higher BMI, more genotype 3 infection, and higher mean serum levels of triglyceride, alanine aminotransferase and gamma-glutamyl transpeptidase. The clinical relevance of hepatic steatosis in patients with chronic hepatitis C includes a close correlation with hepatic fibrosis, and a poor response to combination peginterferon and ribavirin treatment. In addition, hepatic steatosis has been reported to associate with increased frequency of hepatocellular carcinoma in patients with chronic HCV infection. Whether life style modification such as weight reduction or adding an insulin resistance reducing agent such as metformin or thiazolidinediones combined with current standard peginterferon plus ribavirin treatment will benefit to the chronic hepatitis C patients with hepatic steatosis deserves further evaluation.
C1 [Lee, Shou-Dong] Taipei Vet Gen Hosp, Vice Superintendant Off, Dept Family Med, Taipei 11217, Taiwan.
   [Hwang, Shinn-Jang] Vet Gen Hosp, Dept Med, Div Gastroenterol, Taipei 11217, Taiwan.
   [Hwang, Shinn-Jang; Lee, Shou-Dong] Natl Yang Ming Univ, Sch Med, Taipei 112, Taiwan.
C3 Taipei Veterans General Hospital; National Yang Ming Chiao Tung
   University
RP Lee, SD (corresponding author), Taipei Vet Gen Hosp, Vice Superintendant Off, Dept Family Med, 201,Sect 2,Shih Pai Rd, Taipei 11217, Taiwan.
EM sdlee@vghtpe.gov.tw
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TC 39
Z9 39
U1 1
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0815-9319
EI 1440-1746
J9 J GASTROEN HEPATOL
JI J. Gastroenterol. Hepatol.
PD JAN
PY 2011
VL 26
SU 1
BP 96
EP 101
DI 10.1111/j.1440-1746.2010.06542.x
PG 6
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 702FQ
UT WOS:000285880400012
PM 21199519
DA 2025-06-11
ER

PT J
AU Giallauria, F
   Orio, F
   Palomba, S
   Lombardi, G
   Colao, A
   Vigorito, C
AF Giallauria, Francesco
   Orio, Francesco
   Palomba, Stefano
   Lombardi, Gaetano
   Colao, Annamaria
   Vigorito, Carlo
TI Cardiovascular risk in women with polycystic ovary syndrome
SO JOURNAL OF CARDIOVASCULAR MEDICINE
LA English
DT Review
DE cardiovascular risk factors; diet; exercise training; hyperandrogenemia;
   hyperinsulinemia; insulin resistance; obesity; polycystic ovary syndrome
ID LEFT-VENTRICULAR DYSFUNCTION; EXERCISE TRAINING-PROGRAM; CHRONIC
   HEART-FAILURE; IMPAIRED GLUCOSE-TOLERANCE; HORMONE-BINDING GLOBULIN;
   LIFE-STYLE MODIFICATION; OBESE WOMEN; WEIGHT-LOSS; INSULIN SENSITIVITY;
   YOUNG-WOMEN
AB Polycystic ovary syndrome (PCOS) is a heterogeneous disease affecting about 5-10% of reproductive-age female population, which is predominantly characterized by chronic anovulation, hyperandrogenism and insulin resistance. PCOS women represent an intriguing biological model illustrating the relationship between hormonal pattern and cardiovascular risk profile, presenting a cluster of cardiovascular features, such as obesity, insulin resistance, hypertension, impaired cardiopulmonary functional capacity, autonomic dysfunction and low-grade chronic inflammation. Metabolic syndrome should be also considered in the clinical evaluation and management of PCOS. The treatment of PCOS and its complications should not be based solely on pharmacological therapies trying to improve hyperandrogenism, hyperinsulinemia and insulin resistance. Although mounting evidence recognizes the beneficial effects of lifestyle modifications, the clinical management of PCOS is not sufficiently focused on long-term maintenance of both exercise and dietary interventions and on further aspects of this syndrome (i.e. psychological status). Taking into consideration the patients' young age and the devastating effects of PCOS on hormonal and metabolic pattern, this complex and multifaceted disease requires a comprehensive approach in order to achieve concrete beneficial effects for PCOS patients. Multidisciplinary programs, including dietary and educational counseling, exercise training, stress management and psychosocial support, might represent the gold standard for adequate reduction of cardiovascular risk in young women with PCOS.
C1 [Orio, Francesco] Univ Naples Federico II, Dept Mol & Clin Endocrinol & Oncol, I-80131 Naples, Italy.
   [Orio, Francesco; Lombardi, Gaetano; Colao, Annamaria] Univ Naples Parthenope, Fac Exercise Sci, Chair Endocrinol, Naples, Italy.
   [Palomba, Stefano] Univ Catanzaro Magna Graecia, Dept Obstet & Gynaecol, Catanzaro, Italy.
   [Giallauria, Francesco; Vigorito, Carlo] Univ Naples Federico II, Dept Clin Med Cardiovasc & Immunol Sci, I-80131 Naples, Italy.
C3 University of Naples Federico II; Parthenope University Naples; Magna
   Graecia University of Catanzaro; University of Naples Federico II
RP Giallauria, F (corresponding author), Univ Naples Federico II, Dept Clin Med Cardiovasc & Immunol Sci, Via S Pansini 5, I-80131 Naples, Italy.
EM giallauria@libero.it
RI Giallauria, Francesco/B-5681-2013; Colao, Annamaria/A-7671-2011
OI Palomba, Stefano/0000-0003-2767-8295
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NR 72
TC 64
Z9 71
U1 0
U2 7
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1558-2027
EI 1558-2035
J9 J CARDIOVASC MED
JI J. Cardiovasc. Med.
PD OCT
PY 2008
VL 9
IS 10
BP 987
EP 992
DI 10.2459/JCM.0b013e32830b58d4
PG 6
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 355EB
UT WOS:000259690900002
PM 18799960
DA 2025-06-11
ER

PT J
AU Alipour, A
   Elte, JWF
   van Zaanen, HCT
   Rietveld, AP
   Cabezas, MC
AF Alipour, A.
   Elte, J. W. F.
   van Zaanen, H. C. T.
   Rietveld, A. P.
   Cabezas, M. Castro
TI Postprandial inflammation and endothelial dysfuction
SO BIOCHEMICAL SOCIETY TRANSACTIONS
LA English
DT Article; Proceedings Paper
CT Conference on Diet and Cardiovascular Health - Chylomicron Remnants and
   Their Emerging Roles in Vascular Dysfunction in Atherogenesis
CY DEC 18-19, 2006
CL Royal Vet Coll, London, ENGLAND
HO Royal Vet Coll
DE chylomicron; complement; inflammation; leucocyte; lipaemia; oxidative
   stress
ID COMPLEMENT COMPONENT-3 RESPONSE; ACYLATION-STIMULATING PROTEIN;
   CORONARY-ARTERY-DISEASE; C-REACTIVE PROTEIN; DIABETES-MELLITUS;
   RISK-FACTORS; ATHEROSCLEROSIS; HEALTHY; HYPERTRIGLYCERIDEMIA;
   LIPOPROTEIN
AB Postprandial hyperlipiclaermia is a common metabolic disturbance in atherosclerosis. During the postprandial phase, chylomicrons and their remnants can penetrate the intact endothelium and cause foam cell formation. These particles are highly atherogenic after modification. People in the Western world are non-fasting for most of the day, which consequently leads to a continuous challenge of the endothelium by atherogenic lipoproteins and their remnants. Furthermore, atherosclerosis is considered a low-grade chronic inflammatory disease. Many studies have shown that the process of atherogenesis in part starts with the interaction between the activated leucocytes and activated endothelium. Postprandial lipoproteins can activate leucocytes in the blood and up-regulate the expression of leucocyte adhesion molecules on the endothelium, facilitating adhesion and migration of inflammatory cells into the subenclothelial space. Another inflammatory process associated with postprandial lipaemia is the activation of the complement system. Its central component C3 has been associated with obesity, coronary sclerosis, the metabolic syndrome and fasting and postprandial TAGs (triacylglycerols). Moreover, chylomicrons are the strongest stimulators of adipocyte C3 production via activation of the alternative complement cascade. A postprandial C3 increment has been shown in healthy subjects and in patients with CAD (coronary artery disease) and with FCHL (familial combined hyperlipidaemia). Postprandial lipaemia has been related to TAG and free fatty acid metabolism. All of these mechanisms provide an alternative explanation for the atherogenicity of the postprandial period.
C1 St Franciscus Gasthuis, Dept Internal Med, Ctr Diabet & Vasc Med, NL-3004 BA Rotterdam, Netherlands.
C3 Franciscus Gasthuis
RP Cabezas, MC (corresponding author), St Franciscus Gasthuis, Dept Internal Med, Ctr Diabet & Vasc Med, POB 10900, NL-3004 BA Rotterdam, Netherlands.
EM m.castrocabezas@sfg.nl
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NR 48
TC 89
Z9 99
U1 0
U2 4
PU PORTLAND PRESS LTD
PI LONDON
PA 5TH FLR, 90 HIGH HOLBORN, LONDON WC1V 6LJ, ENGLAND
SN 0300-5127
EI 1470-8752
J9 BIOCHEM SOC T
JI Biochem. Soc. Trans.
PD JUN
PY 2007
VL 35
BP 466
EP 469
DI 10.1042/BST0350466
PN 3
PG 4
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Biochemistry & Molecular Biology
GA 181OB
UT WOS:000247444900009
PM 17511629
DA 2025-06-11
ER

PT J
AU Wang, SM
   Chang, HH
   Chang, YH
   Tsai, TY
   Chen, PS
   Lu, RB
   Wang, TY
AF Wang, Shao-Ming
   Chang, Hui Hua
   Chang, Yun-Hsuan
   Tsai, Tsung-Yu
   Chen, Po See
   Lu, Ru-Band
   Wang, Tzu-Yun
TI Shortening of telomere length may be associated with inflammatory
   cytokine levels in patients with bipolar disorder
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Bipolar disorder; Aging; Telomere length; Inflammatory cytokines
ID MAJOR DEPRESSIVE DISORDER; OXIDATIVE STRESS; SUBTHRESHOLD BIPOLARITY;
   METABOLIC SYNDROME; RATING-SCALE; EPIDEMIOLOGY; METAANALYSIS; HYPOMANIA;
   DISEASE; BDNF
AB Background: Bipolar disorder (BD) is hypothesized to be associated with accelerated biological aging. Telomere length (TL) is a biomarker of aging, and although TL decreases with each cell division, the rate of telomere shortening may be affected by inflammation. We aimed to investigate whether TL is decreased in BD patients and to determine the association between TL and inflammatory markers in such patients. Methods: 137 BD patients and 118 healthy controls (HCs) were recruited. Leukocyte TL and plasma levels of cytokines [tumor necrosis factor (TNF)-alpha, interleukin (IL)-8, IL-6, IL-10, transforming growth factor (TGF)-beta 1], Creactive protein (CRP), and brain-derived neurotrophic factor (BDNF) were assessed. Results: TL did not differ significantly between the BD patients and HCs after adjustment for potential confounding factors (P = 0.79). TL was significantly negatively associated with age (beta = -0.007, P < 0.001). In addition, log TNF-alpha levels were significantly negatively associated with TL (P = 0.009), in both the BD patients (P = 0.02) and HCs (P = 0.05). Conclusion: We found a significant association between TNF-alpha levels and TL shortening in both BD patients and HCs. However, BD patients did not display increased TL shortening relative to HCs. Studies that involve larger sample sizes and control for the heterogeneity of BD participants will be needed.
C1 [Wang, Shao-Ming] China Med Univ, Grad Inst Biomed Sci, Taichung, Taiwan.
   [Wang, Shao-Ming] China Med Univ, Neurosci & Brain Dis Ctr, Taichung, Taiwan.
   [Chang, Hui Hua; Wang, Tzu-Yun] Natl Cheng Kung Univ, Inst Clin Pharm & Pharmaceut Sci, Coll Med, Tainan, Taiwan.
   [Chang, Hui Hua] Natl Cheng Kung Univ, Coll Med, Sch Pharm, Tainan, Taiwan.
   [Chang, Hui Hua] Natl Cheng Kung Univ, Natl Cheng Kung Univ Hosp, Coll Med, Dept Pharm, Tainan, Taiwan.
   [Chang, Hui Hua] Natl Cheng Kung Univ Hosp, Dept Pharm, Dou Liou Branch, Yunlin, Taiwan.
   [Chang, Yun-Hsuan] Natl Cheng Kung Univ, Inst Gerontol, Coll Med, Tainan, Taiwan.
   [Chang, Yun-Hsuan; Chen, Po See] Natl Cheng Kung Univ, Inst Behav Med, Coll Med, Tainan, Taiwan.
   [Chang, Yun-Hsuan; Chen, Po See] Natl Cheng Kung Univ, Dept Psychol, Tainan, Taiwan.
   [Tsai, Tsung-Yu; Chen, Po See; Lu, Ru-Band; Wang, Tzu-Yun] Natl Cheng Kung Univ, Natl Cheng Kung Univ Hosp, Coll Med, Dept Psychiat, 138 Sheng-Li Rd, Tainan 70403, Taiwan.
   [Lu, Ru-Band] Yanjiao Furen Hosp, Hebei, Peoples R China.
   [Chang, Yun-Hsuan] Natl Cheng Kung Univ Hosp, Dept Psychiat, Douliu Branch, Yunlin, Taiwan.
   [Chang, Yun-Hsuan] Natl Chung Hsin Univ, Grad Inst Genom & Bioinformat, Taichung, Taiwan.
C3 China Medical University Taiwan; China Medical University Taiwan;
   National Cheng Kung University; National Cheng Kung University; National
   Cheng Kung University; National Cheng Kung University Hospital; National
   Cheng Kung University; National Cheng Kung University Hospital; National
   Cheng Kung University; National Cheng Kung University; National Cheng
   Kung University; National Cheng Kung University; National Cheng Kung
   University Hospital; National Cheng Kung University; National Cheng Kung
   University Hospital; National Chung Hsing University
RP Wang, TY (corresponding author), Natl Cheng Kung Univ, Natl Cheng Kung Univ Hosp, Coll Med, Dept Psychiat, 138 Sheng-Li Rd, Tainan 70403, Taiwan.
EM wangty@mail.ncku.edu.tw
RI Chen, Po/AAA-6492-2021; Wang, Shao-Ming/JQW-9219-2023; Chang,
   Hui/AGD-4270-2022; Chen, Chien/Q-3826-2018
OI Chang, Yun-Hsuan/0000-0001-8662-2457; Wang,
   Shao-Ming/0000-0003-1479-9100
FU National Science and Technology Council of Taiwan
   [MOST-108-2628-B-006-016, MOST-109-2628-B-006-014, MOST
   111-2314-B-006-033-MY3, MOST 111-2628-B-039-006-MY3 to SMW, NSTC
   111-2628-B-006-010-MY3, NSTC 109-2628-H-006-003-MY2, NSTC
   111-2314-H-006-002-MY3]; National Cheng Kung University Hospital, Taiwan
   [NCKUH-11202040]; Higher Education Sprout Project, Ministry of Education
   to the Headquarters of University Advancement at National Cheng Kung
   University (NCKU) [D112-B5526, D112-G2513, R112-17603, R113-17603]
FX This study was supported by research grants from the National Science
   and Technology Council of Taiwan (formally named the Ministry of Science
   and Technology (MOST-108-2628-B-006-016, MOST-109-2628-B-006-014, and
   MOST 111-2314-B-006-033-MY3 to TYW, MOST 111-2628-B-039-006-MY3 to SMW,
   NSTC 111-2628-B-006-010-MY3 to HHC, NSTC 109-2628-H-006-003-MY2 and NSTC
   111-2314-H-006-002-MY3 to YHC) and National Cheng Kung University
   Hospital, Taiwan (NCKUH-11202040 to TYW). In addition, this research was
   partly supported by the Higher Education Sprout Project, Ministry of
   Education to the Headquarters of University Advancement at National
   Cheng Kung University (NCKU) (Grant Number: D112-B5526, D112-G2513,
   R112-17603, R113-17603) to YHC.
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NR 49
TC 2
Z9 2
U1 0
U2 0
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD NOV 15
PY 2024
VL 365
BP 155
EP 161
DI 10.1016/j.jad.2024.08.084
EA AUG 2024
PG 7
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA E1N3U
UT WOS:001300740700001
PM 39153550
DA 2025-06-11
ER

PT J
AU Cheng, WW
   Cai, CF
   Kreft, I
   Turnsek, TL
   Zu, MY
   Hu, YP
   Zhou, ML
   Liao, ZY
AF Cheng, Wenwen
   Cai, Cifeng
   Kreft, Ivan
   Turnsek, Tamara Lah
   Zu, Mingyan
   Hu, Yongping
   Zhou, Meiliang
   Liao, Zhiyong
TI Tartary Buckwheat Flavonoids Improve Colon Lesions and Modulate Gut
   Microbiota Composition in Diabetic Mice
SO EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Article
ID HIGH-FAT DIET; INSULIN-RESISTANCE; AKKERMANSIA-MUCINIPHILA; INTESTINAL
   MICROBIOTA; METABOLIC SYNDROME; OXIDATIVE STRESS; OBESITY; GLUCOSE;
   INFLAMMATION; ASSOCIATION
AB Tartary buckwheat flavonoids (TBFs) exhibit diverse biological activities, with antioxidant, antidiabetes, anti-inflammatory, and cholesterol-lowering properties. In this study, we investigated the role of TBFs in attenuating glucose and lipid disturbances in diabetic mice and hence preventing the occurrence of diabetes-related colon lesions in mice by regulating the gut microbiota. The results showed that TBFs (1) reversed blood glucose levels and body weight changes; (2) improved levels of serum total cholesterol (TC), triglycerides (TGs), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and fasting insulin; and (3) significantly reduced diabetes-related colon lesions in diabetic mice. In addition, TBFs also affected the diabetes-related imbalance of the gut microbiota and enriched beneficial microbiota, including Akkermansia and Prevotella. The TBF also selectively increased short-chain fatty acid-producing bacteria, including Roseburia and Odoribacter, and decreased the abundance of the diabetes-related gut microbiota, including Escherichia, Mucispirillum, and Bilophila. The correlation analysis indicated that TBFs improved metabolic parameters related to key communities of the gut microbiota. Our data suggested that TBFs alleviated glucose and lipid disturbances and improved colon lesions in diabetic mice, possibly by regulating the community composition of the gut microbiota. This regulation of the gut microbiota composition may explain the observed effects of TBFs to alleviate diabetes-related symptoms.
C1 [Cheng, Wenwen; Cai, Cifeng; Liao, Zhiyong] Wenzhou Univ, Coll Life & Environm Sci, Wenzhou 325035, Peoples R China.
   [Kreft, Ivan] Univ Ljubljana, Jamnikarjeva 101, SL-1000 Ljubljana, Slovenia.
   [Turnsek, Tamara Lah] Natl Inst Biol, Vecna Pot 111, SL-1000 Ljubljana, Slovenia.
   [Zu, Mingyan] Yantai Jinrui Female Prod Co Ltd, Yantai 264000, Peoples R China.
   [Hu, Yongping] Weining Dongfang Shengu Co Ltd, Guizhou 553100, Peoples R China.
   [Zhou, Meiliang] Chinese Acad Agr Sci, Inst Crop Sci, Beijing 100081, Peoples R China.
C3 Wenzhou University; University of Ljubljana; National Institute of
   Biology - Slovenia; Chinese Academy of Agricultural Sciences; Institute
   of Crop Sciences, CAAS
RP Liao, ZY (corresponding author), Wenzhou Univ, Coll Life & Environm Sci, Wenzhou 325035, Peoples R China.; Zhou, ML (corresponding author), Chinese Acad Agr Sci, Inst Crop Sci, Beijing 100081, Peoples R China.
EM chengwenwen@zju.edu.cn; 148256249@qq.com; ivan.kreft@guest.arnes.si;
   tamara.lah@nib.si; 657225153@qq.com; 1339456283@qq.com;
   zhoumeiliang@caas.cn; zyliao@wzu.edu.cn
FU National Key R&D Program of China;  [2017YFE0117600]
FX AcknowledgmentsThis study was supported by grants from the National Key
   R&D Program of China (Grant no. 2017YFE0117600).
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NR 58
TC 9
Z9 10
U1 3
U2 24
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1741-427X
EI 1741-4288
J9 EVID-BASED COMPL ALT
JI Evid.-based Complement Altern. Med.
PD AUG 16
PY 2022
VL 2022
AR 4524444
DI 10.1155/2022/4524444
PG 14
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA 4F3HV
UT WOS:000848406000011
PM 36016679
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Yadav, SS
   Singh, MK
   Hussain, S
   Dwivedi, P
   Khattri, S
   Singh, K
AF Yadav, Suraj S.
   Singh, Manish K.
   Hussain, Sartaj
   Dwivedi, Pradeep
   Khattri, Sanjay
   Singh, Kuldeep
TI Therapeutic spectrum of piperine for clinical practice: a scoping review
SO CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
LA English
DT Review
DE Bioenhancer; clinical studies; black pepper; Piperine; Piper nigrum
ID HIGH-FAT DIET; CANCER STEM-CELLS; EPITHELIAL-MESENCHYMAL TRANSITION;
   SUB-HIMALAYAN REGION; BLOOD-GLUCOSE LEVEL; BLACK PEPPER; OXIDATIVE
   STRESS; ETHNOMEDICINAL PLANTS; MEDICINAL-PLANTS; LONGUM LINN.
AB Translation of traditional knowledge of herbs into a viable product for clinical use is still an uphill task. Piperine, a pungent alkaloid molecule derived from Piper nigrum and Piper longum possesses diverse pharmacological effects. Traditionally, pepper is used for arthritis, bronchitis, gastritis, diarrhea, snake bite, menstrual pain, fever, and bacterial infections, etc. The anti-inflammatory, antioxidant and immunomodulatory actions of piperine are the possible mechanisms behind its therapeutic potential. Various in-silico and experimental studies have shown piperine as a possible promising molecule in coronavirus disease (COVID-19), ebola, and dengue due to its immunomodulatory and antiviral activities. The other important clinical applications of piperine are due to its bio enhancing effect on drugs, by modulating, absorption in the gastrointestinal tract, altering activities of transporters like p-glycoprotein substrates, and modulating drug metabolism by altering the expression of cytochrome P450 or UDP-glucuronosyltransferase enzymes. Piperine attracted clinicians in treating patients with arthritis, metabolic syndrome, diabetes, skin infections, gastric and liver disorders. This review focused on systematic, evidence-based insight into the use of piperine in clinical settings and mechanistic details behind its therapeutic actions. Also, highlights a number of clinical trials of piperine at various stages exploring its clinical application in cancer, neurological, respiratory, and viral disease, etc.
C1 [Yadav, Suraj S.; Hussain, Sartaj; Khattri, Sanjay] KGMU, Dept Pharmacol, Lucknow, Uttar Pradesh, India.
   [Singh, Manish K.] GMC, Dept Biochem, Badaun, India.
   [Dwivedi, Pradeep] AIIMS, Dept Pharmacol, Jodhpur, Rajasthan, India.
   [Singh, Kuldeep] AIIMS, Dept Paediat, Jodhpur, Rajasthan, India.
C3 King George's Medical University; All India Institute of Medical
   Sciences (AIIMS) Jodhpur; All India Institute of Medical Sciences
   (AIIMS) Jodhpur
RP Dwivedi, P (corresponding author), AIIMS, Dept Pharmacol, Jodhpur, Rajasthan, India.
EM dr.prad99@gmail.com
RI hussain, sartaj/ISV-3303-2023; Singh, Kuldeep/AAE-9513-2020; Yadav,
   Suraj Singh/AGI-1700-2022
OI Yadav, Suraj Singh/0000-0002-3482-9664; hussain,
   sartaj/0000-0003-0582-6808; Singh, Kuldeep/0000-0002-9375-3233; DWIVEDI,
   PRADEEP/0000-0001-6709-3780
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NR 233
TC 23
Z9 23
U1 7
U2 57
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1040-8398
EI 1549-7852
J9 CRIT REV FOOD SCI
JI Crit. Rev. Food Sci. Nutr.
PD AUG 29
PY 2023
VL 63
IS 22
BP 5813
EP 5840
DI 10.1080/10408398.2021.2024792
EA DEC 2021
PG 28
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA R3WT5
UT WOS:000740572100001
PM 34996326
DA 2025-06-11
ER

PT J
AU Ahn, E
   Lee, J
   Han, J
   Lee, SM
   Kwon, KS
   Hwang, GS
AF Ahn, Eunyong
   Lee, Jueun
   Han, Jisu
   Lee, Seung-Min
   Kwon, Ki-Sun
   Hwang, Geum-Sook
TI Glutathione is an aging-related metabolic signature in the mouse kidney
SO AGING-US
LA English
DT Article
DE metabolomics; transcriptomics; renal aging; glutathione metabolism
ID LIPID-METABOLISM; DISEASE; STRESS; KLOTHO
AB The ability to maintain systemic metabolic homeostasis through various mechanisms represents a crucial strength of kidneys in the study of metabolic syndrome or aging. Moreover, age-associated kidney failure has been widely accepted. However, efforts to demonstrate aging-dependent renal metabolic rewiring have been limited.
   In the present study, we investigated aging-related renal metabolic determinants by integrating metabolomic and transcriptomic data sets from kidneys of young (3 months, n = 7 and 3 for respectively) and old (24 months, n = 8 and 3 for respectively) naive C57BL/6 male mice. Metabolite profiling analysis was conducted, followed by data processing via network and pathway analyses, to identify differential metabolites. In the aged group, the levels of glutathione and oxidized glutathione were significantly increased, but the levels of gamma-glutamyl amino acids, amino acids combined with the gamma-glutamyl moiety from glutathione by membrane transpeptidases, and circulating glutathione levels were decreased. In transcriptomic analysis, differential expression of metabolic enzymes is consistent with the hypothesis of aging-dependent rewiring in renal glutathione metabolism; pathway and network analyses further revealed the increased expression of immunerelated genes in the aged group.
   Collectively, our integrative analysis results revealed that defective renal glutathione metabolism is a signature of renal aging. Therefore, we hypothesize that restraining renal glutathione metabolism might alleviate or delay age-associated renal metabolic deterioration, and aberrant activation of the renal immune system.
C1 [Ahn, Eunyong; Lee, Jueun; Han, Jisu; Hwang, Geum-Sook] Western Seoul Ctr, Korea Basic Sci Inst, Integrated Metabol Res Grp, Seoul 03759, South Korea.
   [Lee, Seung-Min; Kwon, Ki-Sun] Korea Res Inst Biosci & Biotechnol, Aging Res Ctr, Daejeon 34141, South Korea.
   [Kwon, Ki-Sun] Aventi Inc, Daejeon 34141, South Korea.
   [Hwang, Geum-Sook] Ewha Womans Univ, Dept Chem & Nano Sci, Seoul 03760, South Korea.
C3 Korea Basic Science Institute (KBSI); Korea Research Institute of
   Bioscience & Biotechnology (KRIBB); Ewha Womans University
RP Hwang, GS (corresponding author), Western Seoul Ctr, Korea Basic Sci Inst, Integrated Metabol Res Grp, Seoul 03759, South Korea.; Hwang, GS (corresponding author), Ewha Womans Univ, Dept Chem & Nano Sci, Seoul 03760, South Korea.
EM gshwang@kbsi.re.kr
RI Ahn, Eunyong/JFA-3686-2023
FU Korea Basic Science Institute [C170200]; National Research Foundation of
   Korea (NRF) - Korea government [2019M3A9D5A01102796, 2020R1A2C2007835]
FX This work was supported by the Korea Basic Science Institute (C170200) ;
   the National Research Foundation of Korea (NRF) grant funded by the
   Korea government (Nos. 2019M3A9D5A01102796 and 2020R1A2C2007835) .
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NR 52
TC 7
Z9 7
U1 2
U2 12
PU IMPACT JOURNALS LLC
PI ORCHARD PARK
PA 6666 E QUAKER ST, STE 1, ORCHARD PARK, NY 14127 USA
SN 1945-4589
J9 AGING-US
JI Aging-US
PD SEP 15
PY 2021
VL 13
IS 17
BP 21009
EP 21028
PG 20
WC Cell Biology; Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Geriatrics & Gerontology
GA WC6VV
UT WOS:000704394600009
PM 34492635
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Hernández-Rubio, A
   Sanvisens, A
   Bolao, F
   Pérez-Mañá, C
   García-Marchena, N
   Fernández-Prendes, C
   Muñoz, A
   Muga, R
AF Hernandez-Rubio, Anna
   Sanvisens, Arantza
   Bolao, Ferran
   Perez-Mana, Clara
   Garcia-Marchena, Nuria
   Fernandez-Prendes, Carla
   Munoz, Alvaro
   Muga, Roberto
TI Association of hyperuricemia and gamma glutamyl transferase as a marker
   of metabolic risk in alcohol use disorder
SO SCIENTIFIC REPORTS
LA English
DT Article
ID URIC-ACID LEVELS; CARDIOVASCULAR-DISEASE; OXIDATIVE STRESS; GOUT; MEN;
   GLUTAMYLTRANSFERASE; ATHEROSCLEROSIS; CONSUMPTION; MORTALITY; GLUCOSE
AB Excessive alcohol consumption leads to overproduction of urates and renal function plays a critical role in serum uric acid levels. We aimed to assess associations of hyperuricemia in patients with alcohol use disorder (AUD) and comparable Glomerular Filtration Rate (GFR). A total of 686 patients undergoing treatment for AUD between 2013 and 2017 were eligible (77% men); age at admission was 47 years [interquartile range (IQR), 40-53 years], age of onset of alcohol consumption was 16 years [IQR, 16-18 years] and the amount of alcohol consumed was 160 g/day [IQR, 120-240 g/day]. Body Mass Index was 24.7 kg/m(2) [IQR, 21.9-28.4 kg/m(2)], eGFR was 105 mL/min/1.73 m(2) [IQR, 95.7-113.0 mL], 9.7% had metabolic syndrome and 23% had advanced liver fibrosis (FIB-4>3.25). Prevalence of hyperuricemia was 12.5%. The eGFR-adjusted multivariate analysis showed that relative to patients with GGT <= 50, those with GGT between 51 and 300 U/L and those with GGT>300 U/L were 4.31 (95% CI 1.62-11.46) and 10.3 (95% CI 3.50-29.90) times more likely to have hyperuricemia, respectively. Our data shows that hyperuricemia in the context of AUD is strongly associated with serum GGT levels and suggest an increased cardio-metabolic risk in this population.
C1 [Hernandez-Rubio, Anna; Sanvisens, Arantza; Garcia-Marchena, Nuria; Muga, Roberto] Univ Autonoma Barcelona, Hosp Univ Germans Trias i Pujol, Dept Internal Med, Badalona 08916, Spain.
   [Bolao, Ferran] Univ Barcelona, Hosp Univ Bel Lvitge IDIBELL, Dept Internal Med, Barcelona, Spain.
   [Perez-Mana, Clara] Univ Autonoma Barcelona, Hosp Univ Germans Trias i Pujol, Dept Clin Pharmacol, Badalona, Spain.
   [Fernandez-Prendes, Carla] Univ Autonoma Barcelona, Hosp Univ Germans Trias i Pujol, Dept Clin Anal & Biochem, Lab Clin Metropolitana Nord, Badalona, Spain.
   [Munoz, Alvaro] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA.
C3 Autonomous University of Barcelona; Hospital Germans Trias i Pujol;
   University of Barcelona; Autonomous University of Barcelona; Hospital
   Germans Trias i Pujol; Autonomous University of Barcelona; Hospital
   Germans Trias i Pujol; Johns Hopkins University; Johns Hopkins Bloomberg
   School of Public Health
RP Muga, R (corresponding author), Univ Autonoma Barcelona, Hosp Univ Germans Trias i Pujol, Dept Internal Med, Badalona 08916, Spain.
EM rmuga.germanstrias@gencat.cat
RI Hernandez-Rubio, Anna/GNP-6805-2022; Pérez-Mañá, Clara/AAC-5817-2021;
   Muga, Roberto/AAY-8655-2021
OI Muga, Roberto/0000-0001-6301-431X; Perez Mana,
   Clara/0000-0001-6343-6918; Hernandez-Rubio, Anna/0000-0001-8612-7827
FU Ministry of Education, Spain [PRX18/00245]; Ministry of Science,
   Innovation and Universities, Carlos III Health Institute (ISCIII),
   European Fund for Regional Development (FEDER), Network for Cooperative
   Research in Health (RETICS), Spain [RD16/0017/0003, PI17/00174,
   CD19/00019]; Ministry of Health, Social Services and Equality, National
   Plan on Drugs (PNSD), Spain [2018/020]; Agency for Management of
   University and Research Grants, Government of Catalonia [2017SGR316]
FX This work was supported by the Ministry of Education, Spain (Grant
   number PRX18/00245) while R.Muga was Visiting Scholar with Professor A.
   Munoz at Johns Hopkins University, Bloomberg School of Public Health,
   Baltimore, MD, USA; the Ministry of Science, Innovation and
   Universities, Carlos III Health Institute (ISCIII), European Fund for
   Regional Development (FEDER), Network for Cooperative Research in Health
   (RETICS), Spain (Grant numbers RD16/0017/0003, PI17/00174, CD19/00019);
   the Ministry of Health, Social Services and Equality, National Plan on
   Drugs (PNSD), Spain (Grant number 2018/020) and, the Agency for
   Management of University and Research Grants, Government of Catalonia
   (Grant number 2017SGR316).
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NR 43
TC 11
Z9 12
U1 0
U2 3
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD NOV 18
PY 2020
VL 10
IS 1
AR 20060
DI 10.1038/s41598-020-77013-1
PG 8
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA PA6BY
UT WOS:000595719800010
PM 33208850
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Zwirchmayr, J
   Kirchweger, B
   Lehner, T
   Tahir, A
   Pretsch, D
   Rollinger, JM
AF Zwirchmayr, Julia
   Kirchweger, Benjamin
   Lehner, Theresa
   Tahir, Ammar
   Pretsch, Dagmar
   Rollinger, Judith M.
TI A robust and miniaturized screening platform to study natural products
   affecting metabolism and survival in Caenorhabditis elegans
SO SCIENTIFIC REPORTS
LA English
DT Article
ID HIGH-FAT DIET; LIFE-SPAN EXTENSION; C. ELEGANS; DRUG DISCOVERY;
   DIMETHYL-SULFOXIDE; INONOTUS-OBLIQUUS; MODEL; CHEMISTRY; INCREASE;
   STRESS
AB In this study a robust, whole organism screening based on Caenorhabditis elegans is presented for the discovery of natural products (NP) with beneficial effects against obesity and age-related diseases. Several parameters of the elaborated workflow were optimized to be adapted for probing multicomponent mixtures combining knowledge from traditional medicine and NP chemistry by generating optimized small-scale extracts considering scarcity of the natural source, solubility issues, and potential assay interferences. The established miniaturized assay protocol allows for in vivo probing of small amounts of even complex samples (similar to 1 mg) to test their ability to increase the nematodes' survival time and the suppression of fat accumulation assessed by Nile red staining as hall marks of "healthy aging". The workflow was applied on 24 herbal and fungal materials traditionally used against symptoms of the metabolic syndrome and revealed promising results for the extracts of Gardenia jasminoides fruits and the sclerotia from Inonotus obliquus. Tested at 100 mu g/mL they were able to significantly reduce the Nile red fluorescence and extend the 50% survival rate (DT50) compared to the control groups. This phenotype-directed in vivo approach opens up new horizons for the selection of natural starting materials and the investigation of their active principles as fast drug discovery tool with predictive value for human diseases.
C1 [Zwirchmayr, Julia; Kirchweger, Benjamin; Lehner, Theresa; Tahir, Ammar; Pretsch, Dagmar; Rollinger, Judith M.] Univ Vienna, Fac Life Sci, Dept Pharmacognosy, Althanstr 14, A-1090 Vienna, Austria.
C3 University of Vienna
RP Rollinger, JM (corresponding author), Univ Vienna, Fac Life Sci, Dept Pharmacognosy, Althanstr 14, A-1090 Vienna, Austria.
EM judith.rollinger@univie.ac.at
RI Rollinger, Judith/Q-5996-2019
OI Zwirchmayr, Julia/0000-0003-2721-3762; Rollinger,
   Judith/0000-0001-6581-0774; Tahir, Ammar/0000-0003-3682-5680;
   Kirchweger, Benjamin/0000-0001-8948-1012; Lehner,
   Theresa/0000-0002-4730-0639
FU DOC-scholarship from the Austrian Academy of Science, Vienna; Austrian
   Drug Screening Institute
FX DP is funded by a DOC-scholarship provided from the Austrian Academy of
   Science, Dr. Ignaz Seipel-Platz 2, 1010 Vienna. TL is partly supported
   by a project of the Austrian Drug Screening Institute. The authors thank
   Dietmar Pum from the University of Natural Ressources and Life Sciences
   for providing expertise in the field of image processing; and diploma
   students Agnes Wieser, Kevin Meszaros and Martina Redl for their
   technical support.
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NR 98
TC 21
Z9 21
U1 1
U2 21
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD JUL 23
PY 2020
VL 10
IS 1
AR 12323
DI 10.1038/s41598-020-69186-6
PG 12
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA MV9TL
UT WOS:000556690900030
PM 32704017
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Caputo, M
   Mele, C
   Prodam, F
   Marzullo, P
   Aimaretti, G
AF Caputo, Marina
   Mele, C.
   Prodam, F.
   Marzullo, P.
   Aimaretti, G.
TI Clinical picture and the treatment of TBI-induced hypopituitarism
SO PITUITARY
LA English
DT Review
DE Traumatic brain injury; Hypopituitarism; Replacement therapy
ID TRAUMATIC BRAIN-INJURY; QUALITY-OF-LIFE; GROWTH-HORMONE REPLACEMENT;
   ANEURYSMAL SUBARACHNOID HEMORRHAGE; ANTERIOR-PITUITARY DYSFUNCTION;
   METABOLIC SYNDROME; GH DEFICIENCY; ACUTE-PHASE; FACTOR-I;
   BODY-COMPOSITION
AB Traumatic brain injury (TBI) is an important public health problem with an increasing incidence in the last years. Relatively few cases are fatal; most individuals will survive and, in the long-term, the sequalae of TBI will include neuroendocrine dysfunctions with a much higher frequency than previously suspected. Patients who develop hypopituitarism after TBI present manifestations due to the number of deficient hormones, severity of hormonal deficiency, and the duration of hypopituitarism without diagnosis and treatment. The clinical spectrum of hypopituitarism is very large and many signs and symptoms of TBI survivors such as fatigue, concentration difficulties, depressive symptoms are nonspecific and overlap with symptoms of post-traumatic stress disorder and variably severe hypopituitarism related to brain damage remaining undiagnosed. This can explain why the diagnosis of hypopituitarism is often missed or delayed after this condition with potentially serious and hazardous consequences for the affected patients. Moreover, clinical experience cumulatively suggests that TBI-associated hypopituitarism is associated with poor recovery and worse outcome, since post-traumatic hypopituitarism is independently associated with cognitive impairment, poor quality of life, abnormal body composition, and adverse metabolic profile. In the present review, the current data related to clinical consequences of pituitary dysfunction after TBI in adult patients and therapeutic approaches are reported.
C1 [Caputo, Marina; Mele, C.; Prodam, F.; Marzullo, P.; Aimaretti, G.] Univ Piemonte Orientale, Dept Translat Med, Endocrinol, Via Solaroli 17, I-28100 Novara, Italy.
   [Prodam, F.] Univ Piemonte Orientale, Interdisciplinary Res Ctr Autoimmune Dis, Novara, Italy.
   [Prodam, F.] Univ Piemonte Orientale, Dept Hlth Sci, Via Solaroli 17, I-28100 Novara, Italy.
   [Marzullo, P.] Osped San Giuseppe Verbania, IRCCS Ist Auxol Italiano, Div Gen Med, Verbania, Italy.
C3 University of Eastern Piedmont Amedeo Avogadro; University of Eastern
   Piedmont Amedeo Avogadro; University of Eastern Piedmont Amedeo
   Avogadro; IRCCS Istituto Auxologico Italiano
RP Caputo, M (corresponding author), Univ Piemonte Orientale, Dept Translat Med, Endocrinol, Via Solaroli 17, I-28100 Novara, Italy.
EM marina.caputo@hotmail.com
RI Prodam, Flavia/B-8844-2013; Gaidano, Gianluca/AAW-2773-2021; Caputo,
   Marina/AAC-6707-2022; Mele, Chiara/ABG-2902-2020
OI Prodam, Flavia/0000-0001-9660-5335; Mele, Chiara/0000-0003-2880-9373
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NR 83
TC 20
Z9 20
U1 1
U2 6
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1386-341X
EI 1573-7403
J9 PITUITARY
JI Pituitary
PD JUN
PY 2019
VL 22
IS 3
SI SI
BP 261
EP 269
DI 10.1007/s11102-019-00956-w
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA IH9ZO
UT WOS:000474865400008
PM 30929220
DA 2025-06-11
ER

PT J
AU Martinez-Herrera, M
   Silvestre, FJ
   Silvestre-Rangil, J
   López-Domènech, S
   Bañuls, C
   Rocha, M
AF Martinez-Herrera, Mayte
   Silvestre, Francisco Javier
   Silvestre-Rangil, Javier
   Lopez-Domenech, Sandra
   Banuls, Celia
   Rocha, Milagros
TI Levels of serum retinol-binding protein 4 before and after non-surgical
   periodontal treatment in lean and obese subjects: An interventional
   study
SO JOURNAL OF CLINICAL PERIODONTOLOGY
LA English
DT Article
DE non-surgical periodontal treatment; obesity; periodontal diseases;
   periodontitis; RBP4
ID POLYCYSTIC-OVARY-SYNDROME; BODY-MASS INDEX; INSULIN-RESISTANCE;
   OXIDATIVE STRESS; METABOLIC SYNDROME; ASSOCIATION;
   RETINOL-BINDING-PROTEIN-4; WEIGHT; INFLAMMATION; INDIVIDUALS
AB AimWe aimed to evaluate serum RBP4 levels before and after periodontal therapy in lean and obese subjects with chronic periodontitis (CP) in order to determine its possible association with periodontitis.
   Materials and MethodsThis is an interventional study for which a total of 112 lean and 119 obese subjects were recruited. Patients with CP were evaluated before and after three months of non-surgical periodontal treatment. Periodontal, anthropometric, biochemical parameters and serum levels of TNF-, IL-6, hs-CRP and RBP4 were assessed.
   ResultsSerum RBP4 levels were associated with an increased probability of periodontitis (OR=1.60; 95% CI: 1.02-2.50), showing patients with CP to have higher RBP4 levels than those without CP in both lean and obese populations (3.35 vs 3.06 and 3.74 vs 3.21, respectively). Following periodontal treatment, RBP4 and TNF- decreased, and all periodontal parameters improved to the same extent in both groups, except for number of teeth with probing depth (PD) 4mm, which improved to a less extent in obese than in lean subjects. In the multivariable regression model, the number of teeth with PD 4mm was independently associated with RBP4 (=0.192).
   ConclusionRBP4 was associated with chronic periodontitis before and after non-surgical periodontal treatment.
C1 [Martinez-Herrera, Mayte; Silvestre, Francisco Javier] Univ Hosp Doctor Peset FISABIO, Serv Stomatol, Valencia, Spain.
   [Martinez-Herrera, Mayte; Silvestre, Francisco Javier; Silvestre-Rangil, Javier] Univ Valencia, Dept Stomatol, Valencia, Spain.
   [Lopez-Domenech, Sandra; Banuls, Celia; Rocha, Milagros] Univ Hosp Doctor Peset FISABIO, Serv Endocrinol & Nutr, Valencia, Spain.
   [Rocha, Milagros] Univ Valencia, CIBER Hepat & Digest Dis, CIBER Res Grp CB06 04 0071, Valencia, Spain.
C3 University of Valencia; CIBER - Centro de Investigacion Biomedica en
   Red; CIBEREHD; University of Valencia
RP Silvestre, FJ (corresponding author), Univ Hosp Doctor Peset FISABIO, Serv Stomatol, Valencia, Spain.; Rocha, M (corresponding author), FISABIO Univ Hosp Dr Peset, Serv Endocrinol & Nutr, Valencia, Spain.
EM francisco.silvestre@uv.es; milagros.rocha@uv.es
RI Silvestre, Francisco Javier/AEX-9672-2022; Silvestre-Rangil,
   Javier/HPF-6536-2023; Domènech, Sandra/AAA-9732-2020; Banuls,
   Celia/H-7359-2017; Rocha, Milagros/I-4987-2015
OI Martinez-Herrera, Mayte/0000-0003-1965-7099; Silvestre, Francisco
   Javier/0000-0001-7858-7735; Banuls, Celia/0000-0001-8077-7642;
   Silvestre-Rangil, Javier/0000-0003-4356-5063; Lopez Domenech,
   Sandra/0000-0003-2067-9308; Rocha, Milagros/0000-0003-2923-6546
FU Carlos III Health Institute [PI16/00301]; Valencian Regional Ministry of
   Education [GV/2016/169]; FISABIO [UGP-15-220]; European Regional
   Development Fund (ERDF "A way to build Europe")
FX This study was supported by grants PI16/00301 from Carlos III Health
   Institute, GV/2016/169 from the Valencian Regional Ministry of Education
   and UGP-15-220 from FISABIO, and has been cofunded by the European
   Regional Development Fund (ERDF "A way to build Europe"). No external
   funding, apart from the support of the authors' institution, was
   available for this study.
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Z9 18
U1 0
U2 15
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0303-6979
EI 1600-051X
J9 J CLIN PERIODONTOL
JI J. Clin. Periodontol.
PD MAR
PY 2018
VL 45
IS 3
BP 336
EP 344
DI 10.1111/jcpe.12840
PG 9
WC Dentistry, Oral Surgery & Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dentistry, Oral Surgery & Medicine
GA FV9QN
UT WOS:000424923300007
PM 29150947
DA 2025-06-11
ER

PT J
AU Schliefsteiner, C
   Hirschmugl, B
   Kopp, S
   Curcic, S
   Bernhart, EM
   Marsche, G
   Lang, U
   Desoye, G
   Wadsack, C
AF Schliefsteiner, Carolin
   Hirschmugl, Birgit
   Kopp, Susanne
   Curcic, Sanja
   Bernhart, Eva Maria
   Marsche, Gunther
   Lang, Uwe
   Desoye, Gernot
   Wadsack, Christian
TI Maternal Gestational Diabetes Mellitus increases placental and foetal
   lipoprotein-associated Phospholipase A2 which might exert protective
   functions against oxidative stress
SO SCIENTIFIC REPORTS
LA English
DT Article
ID PLATELET-ACTIVATING-FACTOR; FACTOR-ACETYLHYDROLASE ACTIVITY; A(2)
   LP-PLA(2) ACTIVITY; PAF-AH; ALTERED DISTRIBUTION; METABOLIC SYNDROME;
   PLASMA; EXPRESSION; OBESITY; WOMEN
AB Increased Lipoprotein associated phospholipase A(2) (LpPLA(2)) has been associated with inflammatory pathologies, including Type 2 Diabetes. Studies on LpPLA(2) and Gestational Diabetes Mellitus (GDM) are rare, and have focused mostly on maternal outcome. In the present study, we investigated whether LpPLA(2) activity on foetal lipoproteins is altered by maternal GDM and/or obesity (a major risk factor for GDM), thereby contributing to changes in lipoprotein functionality. We identified HDL as the major carrier of LpPLA(2) activity in the foetus, which is in contrast to adults. We observed marked expression of LpPLA(2) in placental macrophages (Hofbauer cells; HBCs) and found that LpPLA(2) activity in these cells was increased by insulin, leptin, and pro-inflammatory cytokines. These regulators were also increased in plasma of children born from GDM pregnancies. Our results suggest that insulin, leptin, and pro-inflammatory cytokines are positive regulators of LpPLA(2) activity in the foeto-placental unit. Of particular interest, functional assays using a specific LpPLA(2) inhibitor suggest that high-density lipoprotein (HDL)-associated LpPLA(2) exerts anti-oxidative, athero-protective functions on placental endothelium and foetus. Our results therefore raise the possibility that foetal HDL-associated LpPLA(2) might act as an anti-inflammatory enzyme improving vascular barrier function.
C1 [Schliefsteiner, Carolin; Hirschmugl, Birgit; Kopp, Susanne; Lang, Uwe; Desoye, Gernot; Wadsack, Christian] Med Univ Graz, Dept Obstet & Gynaecol, Graz, Austria.
   [Curcic, Sanja; Marsche, Gunther] Med Univ Graz, Dept Clin & Expt Pharmacol, Graz, Austria.
   [Bernhart, Eva Maria] Med Univ Graz, Inst Mol Biol & Biochem, Graz, Austria.
   [Hirschmugl, Birgit; Wadsack, Christian] BioTechMed Graz, Graz, Austria.
C3 Medical University of Graz; Medical University of Graz; Medical
   University of Graz
RP Wadsack, C (corresponding author), Med Univ Graz, Dept Obstet & Gynaecol, Graz, Austria.; Wadsack, C (corresponding author), BioTechMed Graz, Graz, Austria.
EM christian.wadsack@medunigraz.at
RI Curcic, Sanja/HNR-9501-2023
OI Desoye, Gernot/0000-0002-5715-3230; Curcic, Sanja/0000-0003-3129-3734;
   Marsche, Gunther/0000-0002-2422-5381
FU Austrian Science Fund, FWF, within doctoral program DK-MOLIN [W1421];
   Austrian Science Fund (FWF) [W1241] Funding Source: Austrian Science
   Fund (FWF)
FX CS and BH received funding from a training grant provided by the
   Austrian Science Fund, FWF, within the doctoral program DK-MOLIN
   (W1421). The authors thank Renate Michlmaier and Jasmin Strutz for
   excellent technical support and Bettina Amtmann for patient acquisition.
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NR 72
TC 20
Z9 21
U1 1
U2 8
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD OCT 3
PY 2017
VL 7
AR 12628
DI 10.1038/s41598-017-13051-6
PG 16
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA FI6WZ
UT WOS:000412138800064
PM 28974763
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Yang, JM
   Zhou, XM
   Zhang, X
   Hu, JT
   Gao, L
   Song, YF
   Yu, CX
   Shao, SS
   Yuan, ZS
   Sun, Y
   Yan, HL
   Li, GM
   Zhao, JJ
AF Yang, Jianmei
   Zhou, Xiaoming
   Zhang, Xu
   Hu, Jianting
   Gao, Ling
   Song, Yongfeng
   Yu, Chunxiao
   Shao, Shanshan
   Yuan, Zhongshang
   Sun, Yan
   Yan, Huili
   Li, Guimei
   Zhao, Jiajun
TI Analysis of the correlation between lipotoxicity and pituitary-thyroid
   axis hormone levels in men and male rats
SO ONCOTARGET
LA English
DT Article
DE lipotoxicity; high-fat lard diet; hypertriglyceridemia; anterior
   pituitary hormones; pituitary-thyroid axis; Pathology section
ID INSULIN-RESISTANCE; STIMULATING HORMONE; METABOLIC SYNDROME; ER STRESS;
   KAPPA-B; FAT; DIET; MODEL; CHOLESTEROL; HOMEOSTASIS
AB Lipotoxicity seriously harms human health, but it is unclear whether lipotoxicity is detrimental to the pituitary. We investigated the correlation between serum triglyceride and pituitary axis hormone levels in epidemiological and animal studies. In the epidemiological study, serum thyroid-stimulating hormone (TSH), follicle-stimulating hormone (FSH) and luteinizing hormone (LH) levels were greater in male patients with isolated hypertriglyceridemia than in controls, whereas adrenocorticotropin (ACTH) levels were lower in the patients with hypertriglyceridemia. Pituitary hormone levels correlated with triglyceride levels, even after adjustment for potential confounders. In the animal study, male rats were fed a high-fat or control diet for 28 weeks. As the duration of high-fat feeding increased, the serum and pituitary triglyceride concentrations increased. At early times, the high-fat diet elevated serum TSH and triiodothyronine. At later times, much higher serum TSH levels coupled with reduced thyroxine were observed in the high-fat group. Serum levels of pituitary-gonadal and pituitary-adrenal axis hormones were not affected by the diet. The mRNA and protein expression of Tsh beta were greater in the high-fat group than in the control group, whereas expression of Fsh beta, Lh beta and Acth had no difference between the groups. Overall, serum triglyceride levels were associated with pituitary-thyroid axis hormone levels.
C1 [Yang, Jianmei; Zhou, Xiaoming; Zhang, Xu; Song, Yongfeng; Yu, Chunxiao; Shao, Shanshan; Zhao, Jiajun] Shandong Univ, Shandong Prov Hosp, Dept Endocrinol, Jinan 250100, Shandong, Peoples R China.
   [Yang, Jianmei; Zhou, Xiaoming; Zhang, Xu; Gao, Ling; Song, Yongfeng; Yu, Chunxiao; Shao, Shanshan; Yan, Huili; Zhao, Jiajun] Shandong Acad Clin Med, Inst Endocrinol & Metab, Jinan, Shandong, Peoples R China.
   [Yang, Jianmei; Zhou, Xiaoming; Zhang, Xu; Gao, Ling; Song, Yongfeng; Yu, Chunxiao; Shao, Shanshan; Yan, Huili; Zhao, Jiajun] Shandong Clin Med Ctr Endocrinol & Metab, Jinan, Shandong, Peoples R China.
   [Hu, Jianting] Shandong Acad Pharmaceut Sci, Jinan, Shandong, Peoples R China.
   [Gao, Ling] Shandong Univ, Shandong Prov Hosp, Ctr Sci, Jinan 250100, Shandong, Peoples R China.
   [Yuan, Zhongshang] Shandong Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Jinan 250100, Shandong, Peoples R China.
   [Li, Guimei] Shandong Univ, Shandong Prov Hosp, Dept Pediat Endocrinol, Jinan 250100, Shandong, Peoples R China.
C3 Shandong First Medical University & Shandong Academy of Medical
   Sciences; Shandong University; Shandong First Medical University &
   Shandong Academy of Medical Sciences; Shandong University; Shandong
   University; Shandong University; Shandong First Medical University &
   Shandong Academy of Medical Sciences
RP Zhao, JJ (corresponding author), Shandong Univ, Shandong Prov Hosp, Dept Endocrinol, Jinan 250100, Shandong, Peoples R China.; Zhao, JJ (corresponding author), Shandong Acad Clin Med, Inst Endocrinol & Metab, Jinan, Shandong, Peoples R China.; Zhao, JJ (corresponding author), Shandong Clin Med Ctr Endocrinol & Metab, Jinan, Shandong, Peoples R China.; Li, GM (corresponding author), Shandong Univ, Shandong Prov Hosp, Dept Pediat Endocrinol, Jinan 250100, Shandong, Peoples R China.
EM liguimei2013@126.com; jjzhao@medmail.com.cn
RI zhou, xiaoming/NKO-6551-2025; yang, xiao/HJI-7815-2023; yang,
   hailong/GXH-9625-2022; Zhao, Jiajun/W-2963-2018; Yuan,
   Zhongshang/GVT-8351-2022; shao, shanshan/W-2951-2018
OI Song, yongfeng/0000-0001-8934-3154; Zhao, Jiajun/0000-0003-3267-9292;
   shao, shanshan/0000-0002-7759-3938
FU National Natural Science Foundation of China [81430020, 81230018,
   81300644]; National Basic Research Program [2012CB524900]; medical
   association Foundation of China [13050920477]; Shandong Science and
   Technology Commission of China [2013GSF11817]
FX This work was supported by grants from the National Natural Science
   Foundation of China (81430020, 81230018 and 81300644), the National
   Basic Research Program (2012CB524900), the medical association
   Foundation of China (13050920477) and the Shandong Science and
   Technology Commission of China (2013GSF11817).
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NR 42
TC 10
Z9 11
U1 0
U2 6
PU IMPACT JOURNALS LLC
PI ORCHARD PARK
PA 6666 E QUAKER ST, STE 1, ORCHARD PARK, NY 14127 USA
EI 1949-2553
J9 ONCOTARGET
JI Oncotarget
PD JUN 28
PY 2016
VL 7
IS 26
BP 39332
EP 39344
DI 10.18632/oncotarget.10045
PG 13
WC Oncology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Cell Biology
GA DP6NV
UT WOS:000378614700030
PM 27322428
OA gold, Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Ntchapda, F
   Maguirgue, K
   Adjia, H
   Etet, PFS
   Dimo, T
AF Ntchapda, Fidele
   Maguirgue, Kakesse
   Adjia, Hamadjida
   Etet, Paul Faustin Seke
   Dimo, Theophile
TI Hypolipidemic, antioxidant and anti-atherosclerogenic effects of aqueous
   extract of Zanthoxylum heitzii stem bark in diet-induced
   hypercholesterolemic rats
SO ASIAN PACIFIC JOURNAL OF TROPICAL MEDICINE
LA English
DT Article
DE Zanthoxylum heitzii; Plant extract; Antioxidant; Anti-atherosclerogenic;
   Hypocholestemlemic; Hypolipidemic
ID INTESTINAL CHOLESTEROL ABSORPTION; CORONARY-ARTERY-DISEASE;
   DYSLIPIDEMIA; METABOLISM; EZETIMIBE; INHIBITION; EXPERIENCE; THERAPY;
   MALARIA; LIGNANS
AB Objective: To evaluate anti-dyslipidemic, antioxidant and anti-atherosclerogenic properties of this extract in diet-induced hypercholesterolemic rat, a model of metabolic syndrome-induced atherosclerosis and associated cardiovascular diseases. Methods: Normocholesterolemic (NC) male rats were divided into six groups (n=10) and fed a high-cholesterol (HC) diet for 30 days (5 groups), or normal rat chow (normal control group). Rats given a HC diet also received distilled water (disease Control), the potent hypocholesterolcmic agent with antiatherosclerotic activity atorvastatin (2 mg/kg, positive control), or one of the three doses of Zanthoxylum heitzii stem bark aqueous extract tested (225, 300 and 375 ma/kg) concomitantly for four months. Signs of :general toxicity, body temperature and weight, and water and food intake were monitored in live animals. After sacrifice, lipid profiles and oxidative stress markers were assessed in the blood and liver, aorta, and feces, and histopathological analysis of aorta was performed. Results: Plant extract prevented the elevation of aortic total cholesterol and triglycerides, and hepatic low density lipoprotein, very low density lipoprotein, and total cholesterol. Lipid peroxidation (TBARS) was decreased and aortic atherosclerotic plaque formation prevented. Conclusions: These observations strongly suggest that stem bark aqueous extract of Zanthoxylum heitzii has anti-atherosclerogenic properties, at least partly mediated by antioxidant and hypolipidemic effects.
C1 [Ntchapda, Fidele; Maguirgue, Kakesse] Univ Ngaoundere, Fac Sci, Dept Biol Sci, Ngaoundere, Cameroon.
   [Adjia, Hamadjida] Univ Montreal, Fac Med, Dept Neurosci, Montreal, PQ H3T 1J4, Canada.
   [Etet, Paul Faustin Seke] Qassint Univ, Coll Appl Med Sci, Dept Basic Hlth Sci, Buraydah 51452, Saudi Arabia.
   [Dimo, Theophile] Univ Yaounde, Fac Sci, Dept Anim Biol & Physiol, Yaounde, Cameroon.
C3 Universite de Montreal; Qassim University; University of Yaounde I
RP Ntchapda, F (corresponding author), Univ Ngaoundere, Fac Sci, Dept Biol Sci, POB 454, Ngaoundere, Cameroon.
EM nichapda71@yahoo.fr
RI hamadjida, adjia/AAY-2843-2021; SEKE ETET, Paul F./D-6414-2012
OI Hamadjida, Adjia/0000-0001-9869-6752; SEKE ETET, Paul
   F./0000-0003-2715-3317
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NR 36
TC 14
Z9 15
U1 0
U2 18
PU MEDKNOW PUBLICATIONS & MEDIA PVT LTD
PI MUMBAI
PA B-9, KANARA BUSINESS CENTRE, OFF LINK RD, GHAKTOPAR-E, MUMBAI, 400075,
   INDIA
SN 1995-7645
EI 2352-4146
J9 ASIAN PAC J TROP MED
JI Asian Pac. J. Trop. Med.
PD MAY
PY 2015
VL 8
IS 5
BP 359
EP 365
DI 10.1016/S1995-7645(14)60344-8
PG 7
WC Public, Environmental & Occupational Health; Tropical Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health; Tropical Medicine
GA CH6OF
UT WOS:000354155200003
PM 26003594
OA gold
DA 2025-06-11
ER

PT J
AU Pedroso, DCC
   Miranda-Furtado, CL
   Kogure, GS
   Meola, J
   Okuka, M
   Silva, C
   Calado, RT
   Ferriani, RA
   Keefe, DL
   dos Reis, RM
AF Chielli Pedroso, Daiana Cristina
   Miranda-Furtado, Cristiana Libardi
   Kogure, Gislaine Satyko
   Meola, Juliana
   Okuka, Maja
   Silva, Celso
   Calado, Rodrigo T.
   Ferriani, Rui Alberto
   Keefe, David L.
   dos Reis, Rosana Maria
TI Inflammatory biomarkers and telomere length in women with polycystic
   ovary syndrome
SO FERTILITY AND STERILITY
LA English
DT Article
DE Polycystic ovary syndrome; telomeres; inflammatory biomarkers;
   hyperandrogenism; oxidative stress
ID C-REACTIVE PROTEIN; BETA-CELL FUNCTION; INSULIN-RESISTANCE;
   CARDIOVASCULAR RISK; METABOLIC SYNDROME; GENOMIC ANCESTRY; ANDROGEN
   EXCESS; SYNDROME PCOS; HOMOCYSTEINE; ASSOCIATION
AB Objective: To analyze whether leukocyte telomere length (LTL) is impaired in women with polycystic ovary syndrome (PCOS).
   Design: Case-control study.
   Setting: Hospital.
   Patient(s): A total of 274 women, including 150 patients with PCOS and 124 controls.
   Intervention(s): None.
   Main Outcome Measure(s): Body mass index (BMI), waist circumference, systemic arterial pressure, lipid profile, E-2, LH, T, androstenedione, PRL, TSH, sex hormone-binding globulin, C-reactive protein (CRP), homocysteine, free androgen index, and the homeostatic model of insulin sensitivity (HOMA-IR) index were analyzed. The LTL evaluation was measured by quantitative polymerase chain reaction.
   Result(s): The PCOS group had higher values for weight, BMI, waist circumference, systolic arterial pressure, triglycerides, LH, T, insulin, CRP, free androgen index, and HOMA-IR compared with the control group. Sex hormone-binding globulin and E-2 levels were lower in the PCOS group than in the control group. The LTL did not differ between groups. Age, BMI, and HOMA-IR had no significant effect on LTL. The inflammatory biomarkers CRP and homocysteine were negatively correlated with LTL in patients with PCOS.
   Conclusion(s): Our results showed no differences in LTL between patients with PCOS and controls, but CRP and homocysteine biomarkers negatively correlated with LTL in the PCOS group. (C) 2015 by American Society for Reproductive Medicine.
C1 [Chielli Pedroso, Daiana Cristina; Miranda-Furtado, Cristiana Libardi; Kogure, Gislaine Satyko; Meola, Juliana; Ferriani, Rui Alberto; dos Reis, Rosana Maria] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Obstet & Gynecol, BR-14049900 Ribeirao Preto, SP, Brazil.
   [Okuka, Maja] Univ S Florida, Coll Med, Dept Obstet & Gynecol, Tampa, FL USA.
   [Silva, Celso] Ctr Reprod Med, Orlando, FL USA.
   [Calado, Rodrigo T.] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Internal Med, BR-14049900 Ribeirao Preto, SP, Brazil.
   [Keefe, David L.] NYU, Dept Obstet & Gynecol, Langone Med Ctr, New York, NY 10016 USA.
C3 Universidade de Sao Paulo; State University System of Florida;
   University of South Florida; Universidade de Sao Paulo; NYU Langone
   Medical Center; New York University
RP dos Reis, RM (corresponding author), Univ Sao Paulo, Ribeirao Preto Med Sch, Av Bandeirantes 3900,Campus Usp, BR-14049900 Ribeirao Preto, SP, Brazil.
EM romareis@fmrp.usp.br
RI dos Reis, Rosana/E-3346-2012; Lovato, Juliana/E-3440-2012; Silva,
   Celso/ADG-0269-2022; Furtado, Cristiana/Z-6059-2019; Kogure, Gislaine
   Satyko/K-1249-2016; Furtado, Cristiana/C-8487-2012; Calado,
   Rodrigo/G-2619-2011
OI Kogure, Gislaine Satyko/0000-0002-2860-846X; Furtado,
   Cristiana/0000-0002-8711-8225; Calado, Rodrigo/0000-0002-7966-6029
FU National Council for Scientific and Technological Development (Conselho
   Nacional de Desenvolvimento Cientifico e Tecnologico) [CNPq
   136404/2009-0]; Sao Paulo Research Foundation (Fundacao de Amparo a
   Pesquisa do Estado de Sao Paulo) [FAPESP 2010/08800-8]; National
   Institutes of Science and Technology (Institutos Nacionais de Ciencia e
   Tecnologia); University of Sao Paulo [USP 11.1.31844.01.7]; Fundacao de
   Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [10/08800-8] Funding
   Source: FAPESP
FX This study was supported by the National Council for Scientific and
   Technological Development (Conselho Nacional de Desenvolvimento
   Cientifico e Tecnologico) grant Process CNPq 136404/2009-0, the Sao
   Paulo Research Foundation (Fundacao de Amparo a Pesquisa do Estado de
   Sao Paulo) grant Process FAPESP 2010/08800-8, the National Institutes of
   Science and Technology (Institutos Nacionais de Ciencia e Tecnologia),
   and the University of Sao Paulo, grant Process USP 11.1.31844.01.7.
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NR 54
TC 38
Z9 39
U1 0
U2 10
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0015-0282
EI 1556-5653
J9 FERTIL STERIL
JI Fertil. Steril.
PD FEB
PY 2015
VL 103
IS 2
BP 542
EP 547
DI 10.1016/j.fertnstert.2014.10.035
PG 6
WC Obstetrics & Gynecology; Reproductive Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology; Reproductive Biology
GA CA5RY
UT WOS:000348966700039
PM 25467041
OA Bronze
DA 2025-06-11
ER

PT J
AU Camoes, J
   Coelho, A
   Castro-Diaz, D
   Cruz, F
AF Camoes, Joao
   Coelho, Ana
   Castro-Diaz, David
   Cruz, Francisco
TI Lower Urinary Tract Symptoms and Aging: The Impact of Chronic Bladder
   Ischemia on Overactive Bladder Syndrome
SO UROLOGIA INTERNATIONALIS
LA English
DT Review
DE Overactive bladder; Aging; Vascular disease; Ischemia; Lower urinary
   tract symptoms
ID GERIATRIC VOIDING DYSFUNCTION; NERVE GROWTH-FACTOR; OXIDATIVE STRESS;
   DETRUSOR OVERACTIVITY; RAT MODEL; STRUCTURAL BASIS; ELDERLY POPULATION;
   OUTLET OBSTRUCTION; METABOLIC SYNDROME; RISK-FACTORS
AB Introduction: The overactive bladder syndrome (OAB) is one of the most common and bothersome subsets of lower urinary tract symptoms (LUTS), affecting predominantly the aged population, with a worldwide distribution. This syndrome has not been completely understood, yet the aging process and the decreased blood flow to the bladder have been highlighted as closely related to this phenomenon. Materials and Methods: We performed a search on the online database PubMed/MEDLINE with the following MESH terms: 'Overactive Bladder AND (Ischemia OR Aging OR Vascular Disease)'. We considered manuscripts written in English and published in the last 10 years (2004-2014, October). Additional manuscripts, such as referenced by reviews, were further included. Results: The aging process and the structural and functional changes resulting from an ischemic process emerge as important features that contribute to OAB. The ischemic-induced molecular and structural modifications that occur in the bladder have only recently been the objective of thorough studies, which link cardiovascular risk factors, vascular lesions and OAB. New animal models are being created to test new areas of treatment or prevention of ischemic-induced bladder dysfunction. Conclusion: Recent data point out that several physiological and pathological modifications that occur in the bladder associated with OAB and aging are closely related to ischemia. (C) 2015 S. Karger AG, Basel
C1 [Camoes, Joao; Coelho, Ana; Cruz, Francisco] Univ Porto, Fac Med Porto, P-4200319 Oporto, Portugal.
   [Coelho, Ana; Cruz, Francisco] Univ Porto, I3S, P-4200319 Oporto, Portugal.
   [Coelho, Ana; Cruz, Francisco] Univ Porto, IBMC, P-4200319 Oporto, Portugal.
   [Coelho, Ana; Cruz, Francisco] Univ Porto, Dept Renal Urol & Infect Dis, Fac Med, P-4200319 Oporto, Portugal.
   [Castro-Diaz, David] Hosp Univ Canarias, Dept Urol, Tenerife, Spain.
C3 Universidade do Porto; Universidade do Porto; i3S - Instituto de
   Investigacao e Inovacao em Saude, Universidade do Porto; Universidade do
   Porto; Universidade do Porto; Universidad de la Laguna; University
   Hospital of the Canary Islands
RP Cruz, F (corresponding author), Univ Porto, Dept Doencas Renais Urol & Infecciosas, Fac Med, Alameda Prof Hernani Monteiro, P-4200319 Oporto, Portugal.
EM cruzfjmr@med.up.pt
RI Cruz, Francisco/T-2698-2019; Castro-Diaz, David/P-3338-2015
OI Cruz, Francisco/0000-0003-4551-514X; Castro-Diaz,
   David/0000-0002-4484-9159; Camoes, Joao/0000-0002-7755-8112; Coelho,
   Ana/0000-0002-3286-0262
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NR 66
TC 32
Z9 34
U1 0
U2 7
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0042-1138
EI 1423-0399
J9 UROL INT
JI Urol.Int.
PY 2015
VL 95
IS 4
BP 373
EP 379
DI 10.1159/000437336
PG 7
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA CY9TA
UT WOS:000366748000001
PM 26466093
OA Bronze
DA 2025-06-11
ER

PT J
AU Rosso, N
   Chavez-Tapia, NC
   Tiribelli, C
   Bellentani, S
AF Rosso, Natalia
   Chavez-Tapia, Norberto C.
   Tiribelli, Claudio
   Bellentani, Stefano
TI Translational approaches: From fatty liver to non-alcoholic
   steatohepatitis
SO WORLD JOURNAL OF GASTROENTEROLOGY
LA English
DT Article
DE Fatty Liver; Obesity; Metabolic syndrome; Inflammation; In vitro;
   Experimental model
ID HEPATIC STELLATE CELLS; ENDOPLASMIC-RETICULUM STRESS; PALMITATE-INDUCED
   APOPTOSIS; INSULIN-RESISTANCE; IN-VITRO; ANIMAL-MODELS; TRIGLYCERIDE
   SYNTHESIS; MOLECULAR-MECHANISMS; LIPID-ACCUMULATION; PEPTIDE-1 RECEPTOR
AB Over the past few decades, non-alcoholic fatty liver disease (NAFLD) has become one, if not the most common, cause of chronic liver disease affecting both adults and children. The increasing number of cases at an early age is the most worrying aspect of this pathology, since it provides more time for its evolution. The spectrum of this disease ranges from liver steatosis to steatohepatitis, fibrosis and in some cases, hepatocellular carcinoma. NAFLD may not always be considered a benign disease and hepatologists must be cautious in the presence of fatty liver. This should prompt the use of the available experimental models to understand better the pathogenesis and to develop a rational treatment of a disease that is dangerously increasing. In spite of the growing efforts, the pathogenesis of NAFLD is still poorly understood. In the present article we review the most relevant hypotheses and evidence that account for the progression of NAFLD to non-alcoholic steatohepatitis (NASH) and fibrosis. The available in vitro and in vivo experimental models of NASH are discussed and revised in terms of their validity in translational studies. These studies must be aimed at the discovery of the still unknown triggers or mediators that induce the progression of hepatic inflammation, apoptosis and fibrosis. (C) 2014 Baishideng Publishing Group Inc. All rights reserved.
C1 [Rosso, Natalia; Chavez-Tapia, Norberto C.; Tiribelli, Claudio; Bellentani, Stefano] Fdn Italiana Fegato, I-34149 Trieste, Italy.
   [Chavez-Tapia, Norberto C.] Med Clin & Fdn, Obes & Digest Dis Unit, Mexico City 14050, DF, Mexico.
   [Tiribelli, Claudio] Univ Trieste, Dept Med Sci, I-34149 Trieste, Italy.
   [Bellentani, Stefano] Osped Ramazzini, Azienda USL Modena, Dept Gastroenterol & Endoscopy, I-41012 Carpi, Modena, Italy.
C3 University of Trieste
RP Bellentani, S (corresponding author), Osped Ramazzini, Azienda USL Modena, Dept Gastroenterol & Endoscopy, Via Guido Molinari, I-41012 Carpi, Modena, Italy.
EM bellentanistefano@gmail.com
RI Bellentani, Stefano/L-3600-2019; Tiribelli, Claudio/A-4716-2014; Rosso,
   Natalia/K-9035-2016
OI Bellentani, Stefano/0000-0003-2836-8870; Tiribelli,
   Claudio/0000-0001-6596-7595; Rosso, Natalia/0000-0002-4251-3547
FU European Union Seventh Framework Program (FP7) [Health-F2-2009-241762];
   Italian National Grant MIUR [Art. 13 D.LGS 297/99]; Fondazione Italiana
   Fegato, ONLUS
FX European Union Seventh Framework Program (FP7/2007-2013) under grant
   agreement, No. Health-F2-2009-241762, for the project FLIP; Italian
   National Grant MIUR (Art. 13 D.LGS 297/99 - Progetto Nutrizione e
   Salute); and an in house grant from Fondazione Italiana Fegato, ONLUS
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NR 132
TC 49
Z9 52
U1 1
U2 13
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 7041 Koll Center Parkway, Suite 160, PLEASANTON, CA, UNITED STATES
SN 1007-9327
EI 2219-2840
J9 WORLD J GASTROENTERO
JI World J. Gastroenterol.
PD JUL 21
PY 2014
VL 20
IS 27
BP 9038
EP 9049
DI 10.3748/wjg.v20.i27.9038
PG 12
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA AL8LG
UT WOS:000339389600028
PM 25083077
DA 2025-06-11
ER

PT J
AU Sarvottam, K
   Yadav, RK
AF Sarvottam, Kumar
   Yadav, Raj Kumar
TI Obesity-related inflammation & cardiovascular disease: Efficacy of a
   yoga-based lifestyle intervention
SO INDIAN JOURNAL OF MEDICAL RESEARCH
LA English
DT Review
DE Cardiovascular disease; inflammation; obesity; yoga-based lifestyle
   intervention
ID C-REACTIVE PROTEIN; CORONARY-ARTERY-DISEASE; EPICARDIAL ADIPOSE-TISSUE;
   MIDDLE-AGED MEN; METABOLIC SYNDROME; INSULIN-RESISTANCE; VISCERAL FAT;
   RISK-FACTORS; WEIGHT-LOSS; PROINFLAMMATORY CYTOKINES
AB Obesity is a global health burden and its prevalence is increasing substantially due to changing lifestyle. Chronic adiposity is associated with metabolic imbalance leading to dyslipidaemia, diabetes, hypertension and cardiovascular diseases (CVD). Adipose tissue acts as an endocrine organ releasing several adipocytokines, and is associated with increased levels of tissue and circulating inflammatory biomolecules causing vascular inflammation and atherogenesis. Further, inflammation is also associated independently with obesity as well as CVD. Keeping this in view, it is possible that a reduction in weight may lead to a decrease in inflammation, resulting in CVD risk reduction, and better management of patients with CVD. Lifestyle intervention has been endorsed by several health authorities in prevention and management of chronic diseases. A yoga-based lifestyle intervention appears to be a promising option in reducing the risk for CVD as well as management of patients with CVD as it is simple to follow and cost-effective with high compliance. The efficacy of such lifestyle intervention programmes is multifaceted, and is achieved via reduction in weight, obesity-related inflammation and stress, thereby culminating into risk reduction towards several chronic diseases including CVD. In this review, the association between obesity-related inflammation and CVD, and the role of yoga-based lifestyle intervention in prevention and management of CVD are discussed.
C1 [Sarvottam, Kumar; Yadav, Raj Kumar] All India Inst Med Sci, Dept Physiol, New Delhi 110029, India.
C3 All India Institute of Medical Sciences (AIIMS) New Delhi
RP Yadav, RK (corresponding author), All India Inst Med Sci, Dept Physiol, New Delhi 110029, India.
EM raj3kr@gmail.com
RI Yadav, Raj Kumar/AFT-0686-2022; Sarvottam, Kumar/HPB-5456-2023
OI Yadav, Raj Kumar/0000-0002-5066-7028; sarvottam,
   kumar/0000-0003-1511-2120
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NR 132
TC 29
Z9 33
U1 0
U2 19
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, 400059, INDIA
SN 0971-5916
J9 INDIAN J MED RES
JI Indian J. Med. Res.
PD JUN
PY 2014
VL 139
BP 822
EP 834
PG 13
WC Immunology; Medicine, General & Internal; Medicine, Research &
   Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; General & Internal Medicine; Research & Experimental
   Medicine
GA AP0SW
UT WOS:000341775400007
PM 25109716
DA 2025-06-11
ER

PT J
AU Korkmaz, A
   Topal, T
   Tan, DX
   Reiter, RJ
AF Korkmaz, Ahmet
   Topal, Turgut
   Tan, Dun-Xian
   Reiter, Russel J.
TI Role of melatonin in metabolic regulation
SO REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
LA English
DT Review
DE Syperglycemia; Hyperlipidemia; Dysmetabolism; Melatonin; Circadian
   rhythm
ID TYPE-2 DIABETIC-PATIENTS; REDUCES BLOOD-PRESSURE; OXIDATIVE STRESS;
   CARDIOVASCULAR-DISEASE; INSULIN-RESISTANCE; REACTIVE OXYGEN; EPIGENETIC
   REGULATION; ENDOTHELIAL FUNCTION; CIRCADIAN VARIATION; GLUCOSE-TOLERANCE
AB Although the human genome has remained unchanged over the last 10,000 years, our lifestyle has become progressively more divergent from those of our ancient ancestors. This maladaptive change became apparent with the Industrial Revolution and has been accelerating in recent decades. Socially, we are people of the 21st century, but genetically we remain similar to our early ancestors. In conjunction with this discordance between our ancient, genetically-determined biology and the nutritional, cultural and activity patterns in contemporary Western populations, many diseases have emerged. Only a century ago infectious disease was a major cause of mortality, whereas today non-infectious chronic diseases are the greatest cause of death in the world. Epidemics of metabolic diseases (e.g., cardiovascular diseases, type 2 diabetes, obesity, metabolic syndrome and certain cancers) have become major contributors to the burden of poor health and they are presently emerging or accelerating, in most developing countries. One major lifestyle consequence is light at night and subsequent disrupted circadian rhythms commonly referred to as circadian disruption or chronodisruption. Mounting evidence reveals that particularly melatonin rhythmicity has crucial roles in a variety of metabolic functions as an anti-oxidant, anti-inflammatory chronobiotic and possibly as an epigenetic regulator. This paper provides a brief outline about metabolic dysregulation in conjunction with a disrupted melatonin rhythm.
C1 [Korkmaz, Ahmet; Tan, Dun-Xian; Reiter, Russel J.] Univ Texas Hlth Sci Ctr San Antonio, Dept Cellular & Struct Biol, San Antonio, TX 78229 USA.
   [Korkmaz, Ahmet; Topal, Turgut] Gulhane Mil Med Acad, Dept Physiol, Sch Med, Ankara, Turkey.
C3 University of Texas System; University of Texas Health Science Center at
   San Antonio; Gulhane Military Medical Academy
RP Reiter, RJ (corresponding author), Univ Texas Hlth Sci Ctr San Antonio, Dept Cellular & Struct Biol, Mail Code 7762,7703 Floyd Curl Dr, San Antonio, TX 78229 USA.
EM reiter@uthscsa.edu
RI tan, dun-xian/E-3610-2010; Reiter, Russel/D-3221-2009
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NR 113
TC 108
Z9 118
U1 0
U2 28
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1389-9155
EI 1573-2606
J9 REV ENDOCR METAB DIS
JI Rev. Endocr. Metab. Disord.
PD DEC
PY 2009
VL 10
IS 4
SI SI
BP 261
EP 270
DI 10.1007/s11154-009-9117-5
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 542GH
UT WOS:000273480500003
PM 19911281
DA 2025-06-11
ER

PT J
AU El Kafoury, BM
   Ebrahim, AT
   Ali, MSA
   Mehanna, NS
   Ramadan, GEI
   Morsy, WE
AF El Kafoury, Bataa Mohamed
   Ebrahim, Asmaa Tarek
   Ali, Manal Said Abd-El Hamid
   Mehanna, Nayra Shaker
   Ramadan, Gamil El-Sayed Ibrahim
   Morsy, Wessam Ezzat
TI Short chain fatty acids and GIT hormones mitigate gut barrier disruption
   in high fat diet fed rats supplemented by synbiotics
SO MEDITERRANEAN JOURNAL OF NUTRITION AND METABOLISM
LA English
DT Article
DE GLP-1; serotonin; zonulin; synbiotics; high fat diet; short chain fatty
   acids; insulin resistance
ID GAS-LIQUID-CHROMATOGRAPHY; INTESTINAL PERMEABILITY; INSULIN-RESISTANCE;
   METABOLIC SYNDROME; OXIDATIVE STRESS; WEIGHT-LOSS; MICROBIOTA; OBESITY;
   PROBIOTICS; SEROTONIN
AB High fat diet (HFD) predisposes to many metabolic changes; it may disrupt gut barrier integrity and gut microbiota composition. Synbiotic supplementation may promote host's metabolic health by selective activation of the healthy microorganisms. This study aimed to probe the interaction between synbiotic supplementation, gut microbiota and gut hormones in HFD states. Twenty-seven adult male albino rats, 3 groups, group I: control, group II: HFD received HFD for 12 weeks and group III: synbiotic-supplemented HFD received synbiotic in the last 6 weeks. The anthropometric measurments were measured. Liver transaminases, lipid profile, parameters of insulin resistance, serum serotonin, glucagon like polypeptide-1 (GLP-1), oxidant/antioxidant markers (MDA/GPx), zonulin levels and quantitative cecal short chain fatty acids (SCFA) were assessed. Samples of liver and colon were employed for histopathological studies. Compared to HFD group, synbiotic led to a significant reduction in anthropometric measurements, liver enzymes, atherogenic index, HOMA-IR and MDA denoting improved dyslipidemia, insulin resistance and oxidative state. Moreover, synbiotic supplementation decreased serum zonulin and increased both serum serotonin, GLP-1 and cecal SCFAs. Synbiotic supplementation ameliorated the metabolic derangements and the disturbed integrity of the intestinal barrier induced by HFD. As synbiotics can increase gut hormones (serum GLP-1&serotonin) and SCFAs.
C1 [El Kafoury, Bataa Mohamed; Ebrahim, Asmaa Tarek; Ali, Manal Said Abd-El Hamid; Morsy, Wessam Ezzat] Ain Shams Univ, Fac Med, Physiol, Cairo, Egypt.
   [Ali, Manal Said Abd-El Hamid; Morsy, Wessam Ezzat] Armed Forces Coll Med, Physiol, Cairo, Egypt.
   [Mehanna, Nayra Shaker] Natl Res Ctr, Dairy & Food Microbiol, Cairo, Egypt.
   [Ramadan, Gamil El-Sayed Ibrahim] Natl Res Ctr, Chem Aroma & Flavour, Cairo, Egypt.
C3 Egyptian Knowledge Bank (EKB); Ain Shams University; Armed Forces
   College of Medicine (AFCM); Egyptian Knowledge Bank (EKB); National
   Research Centre (NRC); Egyptian Knowledge Bank (EKB); National Research
   Centre (NRC)
RP Ebrahim, AT (corresponding author), Ain Shams Univ, Fac Med, Physiol, Cairo, Egypt.
EM dr.asmaa_tarek@med.asu.edu.eg
RI Ezzat, Wessam/GQY-8917-2022; Mehanna, Nayra/D-5335-2011
OI Ezzat, Wessam/0000-0002-5474-0747; Mehanna, Nayra/0000-0002-3475-7533
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NR 88
TC 4
Z9 4
U1 1
U2 4
PU IOS PRESS
PI AMSTERDAM
PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS
SN 1973-798X
EI 1973-7998
J9 MEDITERR J NUTR META
JI Mediterr. J. Nutr. Metab.
PY 2023
VL 16
IS 2
BP 139
EP 163
DI 10.3233/MNM-230026
PG 25
WC Medicine, General & Internal; Nutrition & Dietetics
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine; Nutrition & Dietetics
GA N1DK4
UT WOS:001034501600005
DA 2025-06-11
ER

PT J
AU Madkhali, HA
   Ganaie, MA
   Ansari, MN
   Alharthy, KM
   Rehman, NU
   Alamri, MA
   Alkholifi, FK
   Hamad, AM
   Hamadi, A
AF Madkhali, Hassan A.
   Ganaie, Majid A.
   Ansari, Mohd Nazam
   Alharthy, Khalid M.
   Rehman, Najeeb Ur
   Alamri, Mohammed A.
   Alkholifi, Faisal K.
   Hamad, Abubakr M.
   Hamadi, Abdullah
TI Red Yeast Rice Mitigates High-Fat Diet Induced-Obesity Related Vascular
   Dysfunction in Wistar Albino Rats
SO BIOINTERFACE RESEARCH IN APPLIED CHEMISTRY
LA English
DT Article
DE red yeast rice; lipid profile; high-fat diet; endothelial dysfunction
ID CORONARY-ARTERY-DISEASE; ENDOTHELIAL DYSFUNCTION; METABOLIC SYNDROME;
   OXIDATIVE STRESS; OVERWEIGHT; PLANTS
AB The red yeast rice methanolic extract (RYR) was suggested to have promising therapeutic effects against vascular endothelial dysfunction. In the present study, the protective effects of RYR at 200 and 400 mg/kg/day were investigated in a specific animal model that exhibits a high-fat diet (HFD)induced dyslipidemia and vascular endothelium dysfunction. Vascular endothelial reactivity experiments were evaluated using aorta obtained from adult rats in an ex-vivo organ bath setup. Three consecutive weeks of RYR treatment exhibited a significant reduction in body weight (BW), liver weight (LW), and retroperitoneal fat pad weight (RFPW)/BW ratios as compared to HFD only treated rats where a significant body weight gain was observed. RYR treatment also significantly decreased the average daily food intake, waist, lee index, and body mass index compared to rats treated with HFD only. RYR treatment significantly reduced total cholesterol, triglyceride, low-density lipoprotein, and very-low-density lipoprotein levels compared to the HFD group. HFD-induced endothelium dysfunction in the aorta of animals was reversed by RYR treatment, comparable to the HFD group. RYR treatment, specifically at 400 mg/kg/day dose, revealed a significant protective effect on vascular endothelium and an improvement in the lipid panel, hence justifying therapeutic involvement of RYR in dyslipidemia and endothelial dysfunctions.
C1 [Madkhali, Hassan A.; Ansari, Mohd Nazam; Alharthy, Khalid M.; Rehman, Najeeb Ur; Alamri, Mohammed A.; Alkholifi, Faisal K.] Prince Sattam Bin Abdulaziz Univ, Coll Pharm, Dept Pharmacol & Toxicol, Al Kharj, Saudi Arabia.
   [Ganaie, Majid A.] Buraydah Coll, Coll Dent & Pharm, Buraydah, Saudi Arabia.
   [Hamad, Abubakr M.] Prince Sattam Bin Abdulaziz Univ, Dept Basic Sci, Preparatory Year Deanship, Al Kharj, Saudi Arabia.
   [Hamad, Abubakr M.] Univ Gezira, Fac Med Lab Sci, Dept Histopathol & Cytopathol, Wad Madani, Sudan.
   [Hamadi, Abdullah] Univ Tabuk, Fac Appl Med Sci, Med Lab Technol, Tabuk, Saudi Arabia.
C3 Prince Sattam Bin Abdulaziz University; Buraydah Colleges; Prince Sattam
   Bin Abdulaziz University; University of Tabuk
RP Madkhali, HA (corresponding author), Prince Sattam Bin Abdulaziz Univ, Coll Pharm, Dept Pharmacol & Toxicol, Al Kharj, Saudi Arabia.
EM dr_madkhali@hotmail.com; majidsays@gmail.com; nazam.ansari@gmail.com;
   k.alharthy@psau.edu.sa; n.rehman@psau.edu.sa; ma.alamri@psau.edu.sa;
   f.alkholifi@psau.edu.sa; abkr.hamad@gmail.com; a.aldhafri@ut.edu.sa
RI alharthy, khalid/GQY-4562-2022; Alamri, Mohammed/LKL-5409-2024; Hamadi,
   Abdullah/ACN-2036-2022; Hamad, Abubaker/R-7227-2017; Rehman, Najeeb
   Ur/H-8338-2018; Ansari, Mohd Nazam/AAH-7855-2021; Alkholifi,
   Faisal/AGD-3531-2022
OI Rehman, Najeeb Ur/0000-0001-6925-7697; Alamri,
   Mohammed/0000-0003-1534-1388; Ansari, Mohd Nazam/0000-0001-8580-3002;
   Alkholifi, Faisal/0000-0003-3150-3439; , Khalid/0000-0001-6896-3557
FU Deanship of Scientific Research (DSR), Prince Sattam bin Abdulaziz
   University, Al-Kharj, Kingdom of Saudi Arabia
FX The authors are thankful to the Deanship of Scientific Research (DSR),
   Prince Sattam bin Abdulaziz University, Al-Kharj, Kingdom of Saudi
   Arabia, for supporting the study.
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PA POLIZU ST 1-7, BUILDING I, ROOM, I-102, BUCHAREST, ROMANIA
SN 2069-5837
J9 BIOINTERFACE RES APP
JI Biointerface Res. Appl. Chem.
PD DEC 15
PY 2021
VL 11
IS 6
BP 14290
EP 14303
DI 10.33263/BRIAC116.1429014303
PG 14
WC Chemistry, Applied
WE Emerging Sources Citation Index (ESCI)
SC Chemistry
GA RN9HX
UT WOS:000640664600042
OA gold
DA 2025-06-11
ER

PT J
AU Stanciuc, N
   Râpeanu, G
   Bahrim, GE
   Aprodu, I
AF Stanciuc, Nicoleta
   Rapeanu, Gabriela
   Bahrim, Gabriela Elena
   Aprodu, Iuliana
TI The Interaction of Bovine β-Lactoglobulin with Caffeic Acid: From
   Binding Mechanisms to Functional Complexes
SO BIOMOLECULES
LA English
DT Article
DE caffeic acid; beta-lactoglobulin; complexation; antioxidant;
   antidiabetic; binding; in silico
ID WHEY PROTEINS; FLUORESCENCE SPECTROSCOPY; ANTIOXIDANT ACTIVITY;
   PANCREATIC LIPASE; OXIDATIVE STRESS; CROSS-LINKING; POLYPHENOLS;
   DENATURATION; CAROTENOIDS; INHIBITORS
AB In this study, the interaction of native and transglutaminase (Tgase) cross-linked beta-lactoglobulin (beta-LG) with caffeic acid (CA) was examined, aiming to obtain functional composites. Knowledge on the binding affinity and interaction mechanism was provided by performing fluorescence spectroscopy measurements, after heating the native and cross-linked protein at temperatures ranging from 25 to 95 degrees C. Regardless of the protein aggregation state, a static quenching mechanism of intrinsic fluorescence of beta-LG by CA was established. The decrease of the Stern-Volmer constants with the temperature increase indicating the facile dissociation of the weakly bound complexes. The thermodynamic analysis suggested the existence of multiple contact types, such as Van der Waals' force and hydrogen bonds, between beta-LG and CA. Further molecular docking tests indicated the existence of various CA binding sites on the beta-LG surface heat-treated at different temperatures. Anyway, regardless of the simulated temperature, the CA-beta-LG assemblies appeared to be unstable. Compared to native protein, the CA-beta-LG and CA-beta-LG(Tgase)complexes (ratio 1:1) exhibited significantly higher antioxidant activity and inhibitory effects on alpha-glucosidase, alpha-amylase, and pancreatic lipase, enzymes associated with metabolic syndrome. These findings might help the knowledge-based development of novel food ingredients with valuable biological properties.
C1 [Stanciuc, Nicoleta; Rapeanu, Gabriela; Bahrim, Gabriela Elena; Aprodu, Iuliana] Dunarea de Jos Univ Galati, Fac Food Sci & Engn, 111 Domneasca St, Galati 800201, Romania.
C3 Dunarea De Jos University Galati
RP Aprodu, I (corresponding author), Dunarea de Jos Univ Galati, Fac Food Sci & Engn, 111 Domneasca St, Galati 800201, Romania.
EM Nicoleta.Stanciuc@ugal.ro; grapeanu@ugal.ro; Gabriela.Bahrim@ugal.ro;
   iuliana.aprodu@ugal.ro
RI Aprodu, Iuliana/B-3535-2011; Bahrim, Gabriela-Elena/ABB-2043-2020;
   Bahrim, Gabriela-Elena/G-4935-2013
OI Rapeanu, Gabriela/0000-0002-5804-2786; Bahrim,
   Gabriela-Elena/0000-0001-8210-1793
FU Romanian Ministry of Research and Innovation, CCCDI-UEFISCDI, within
   PNCDI programme [PN-III-P1-1.2-PCCDI-2017-0569-PRO-SPER (10PCCI)]
FX Thisworkwas funded by a grant of the Romanian Ministry of Research and
   Innovation, CCCDI-UEFISCDI, project number
   PN-III-P1-1.2-PCCDI-2017-0569-PRO-SPER (10PCCI), within PNCDI programme.
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NR 52
TC 14
Z9 14
U1 2
U2 46
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2218-273X
J9 BIOMOLECULES
JI Biomolecules
PD AUG
PY 2020
VL 10
IS 8
AR 1096
DI 10.3390/biom10081096
PG 14
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA OD1LB
UT WOS:000579615600001
PM 32718063
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Liu, XM
   Wang, JH
   Zhou, MF
   Dai, QY
   Wang, QG
   Li, HM
   Qian, X
AF Liu, Xuemei
   Wang, Jinhua
   Zhou, Mengfan
   Dai, Qian'ying
   Wang, Qin'geng
   Li, Huiming
   Qian, Xin
TI Particulate matter exposure disturbs inflammatory cytokine homeostasis
   associated with changes in trace metal levels in mouse organs
SO SCIENCE OF THE TOTAL ENVIRONMENT
LA English
DT Article
DE Particulate matter; Inflammatory cytokine; Trace metal; Homeostasis
ID OXIDATIVE STRESS; AIR-POLLUTION; METABOLIC SYNDROME; PM2.5; INCREASES;
   ACCUMULATION; EXPRESSION; SYMPTOMS; ELEMENTS; MEGACITY
AB Few studies have focused on the impact of particulate matter (PM) exposure with respect to the relationship between PM-induced inflammation and the levels of trace metals in tissues and organs. In this study, C57BL/6 male mice were exposed to ambient air alongside control mice breathing air filtered through a high-efficiency particulate air (HEPA) filter. In both groups, mRNA levels of pro- and anti-inflammatory cytokines were measured after 4, 8 and 12 weeks together with the trace metal contents of the lungs, heart, liver, hippocampus and blood. PM exposure resulted in a general upward trend in the levels of pro-inflammatory cytokines in lung, heart, liver and hippocampus. By contrast, IL-10 mRNA expression varied depending on the organ, with a continuous upward trend in heart and liver and an up-regulation at 8 weeks followed by a down-regulation at 12 weeks in lung and hippocampus. The disturbed homeostasis of inflammatory cytokines was accompanied by changes in trace metal levels in the mice. These alterations may have constituted a compensatory effect conferring protection from inflammatory damage. However, prolonged PM exposure finally resulted in the deficiency of several essential trace metals in the lungs and hippocampus, which may have contributed to the observed histological changes typical of an inflammatory response. (C) 2020 Elsevier B.V. All rights reserved.
C1 [Liu, Xuemei; Zhou, Mengfan; Dai, Qian'ying; Wang, Qin'geng; Qian, Xin] Nanjing Univ, State Key Lab Pollut Control & Resources Reuse, Sch Environm, Nanjing, Peoples R China.
   [Li, Huiming] Nanjing Normal Univ, Sch Environm, 1 Wenyuan Rd, Nanjing, Peoples R China.
   [Wang, Qin'geng; Qian, Xin] Nanjing Univ Informat Sci & Technol, Jiangsu Collaborat Innovat Ctr Atmospher Environm, Nanjing, Peoples R China.
   [Liu, Xuemei] Huaiyin Inst Technol, Sch Chem Engn, Huaian, Peoples R China.
   [Wang, Jinhua] Anhui Jianzhu Univ, Key Lab Anhui Prov Water Pollut Control & Wastewa, Sch Environm & Energy Engn, Hefei, Peoples R China.
C3 Nanjing University; Nanjing Normal University; Nanjing University of
   Information Science & Technology; Huaiyin Institute of Technology; Anhui
   Jianzhu University
RP Li, HM (corresponding author), Nanjing Normal Univ, Sch Environm, 1 Wenyuan Rd, Nanjing, Peoples R China.; Qian, X (corresponding author), Nanjing Univ, Sch Environm, Xianlin Campus,163 Xianlin Ave, Nanjing, Peoples R China.
EM valen222@126.com; xqian@nju.edu.cn
RI Liu, Xuemei/AAE-1768-2020
FU Natural Science Foundation of Jiangsu Province, China [BK20171339];
   National Natural Science Foundation of China [41771533]
FX This work was supported by the Natural Science Foundation of Jiangsu
   Province, China (Grant No. BK20171339), the National Natural Science
   Foundation of China (Grant No. 41771533).
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NR 61
TC 11
Z9 13
U1 3
U2 37
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0048-9697
EI 1879-1026
J9 SCI TOTAL ENVIRON
JI Sci. Total Environ.
PD JUL 20
PY 2020
VL 727
AR 138377
DI 10.1016/j.scitotenv.2020.138377
PG 11
WC Environmental Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology
GA LT9VD
UT WOS:000537412300009
PM 32330707
DA 2025-06-11
ER

PT J
AU Dewanjee, S
   Chakraborty, P
   Mukherjee, B
   De Feo, V
AF Dewanjee, Saikat
   Chakraborty, Pratik
   Mukherjee, Biswajit
   De Feo, Vincenzo
TI Plant-Based Antidiabetic Nanoformulations: The Emerging Paradigm for
   Effective Therapy
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE bioavailability; diabetes; drug delivery; nanoformulation; natural
   products; phytochemicals
ID SOLID LIPID NANOPARTICLES; PANCREATIC BETA-CELLS; ALPHA-ELEOSTEARIC
   ACID; DRUG-DELIVERY SYSTEM; IN-VIVO EVALUATION; LOADED CHITOSAN
   NANOPARTICLES; ENHANCED ORAL BIOAVAILABILITY; TYPE-2 DIABETES-MELLITUS;
   INDUCED OXIDATIVE STRESS; B SIGNALING PATHWAY
AB Diabetes mellitus is a life-threatening metabolic syndrome. Over the past few decades, the incidence of diabetes has climbed exponentially. Several therapeutic approaches have been undertaken, but the occurrence and risk still remain unabated. Several plant-derived small molecules have been proposed to be effective against diabetes and associated vascular complications via acting on several therapeutic targets. In addition, the biocompatibility of these phytochemicals increasingly enhances the interest of exploiting them as therapeutic negotiators. However, poor pharmacokinetic and biopharmaceutical attributes of these phytochemicals largely restrict their clinical usefulness as therapeutic agents. Several pharmaceutical attempts have been undertaken to enhance their compliance and therapeutic efficacy. In this regard, the application of nanotechnology has been proven to be the best approach to improve the compliance and clinical efficacy by overturning the pharmacokinetic and biopharmaceutical obstacles associated with the plant-derived antidiabetic agents. This review gives a comprehensive and up-to-date overview of the nanoformulations of phytochemicals in the management of diabetes and associated complications. The effects of nanosizing on pharmacokinetic, biopharmaceutical and therapeutic profiles of plant-derived small molecules, such as curcumin, resveratrol, naringenin, quercetin, apigenin, baicalin, luteolin, rosmarinic acid, berberine, gymnemic acid, emodin, scutellarin, catechins, thymoquinone, ferulic acid, stevioside, and others have been discussed comprehensively in this review.
C1 [Dewanjee, Saikat; Chakraborty, Pratik] Jadavpur Univ, Dept Pharmaceut Technol, Adv Pharmacognosy Res Lab, Kolkata 700032, India.
   [Mukherjee, Biswajit] Jadavpur Univ, Dept Pharmaceut Technol, Pharmaceut Res Lab, Kolkata 700032, India.
   [De Feo, Vincenzo] Univ Salerno, Dept Pharm, I-84084 Fisciano, Italy.
C3 Jadavpur University; Jadavpur University; University of Salerno
RP Dewanjee, S (corresponding author), Jadavpur Univ, Dept Pharmaceut Technol, Adv Pharmacognosy Res Lab, Kolkata 700032, India.; De Feo, V (corresponding author), Univ Salerno, Dept Pharm, I-84084 Fisciano, Italy.
EM saikat.dewanjee@jadavpuruniversity.in; pratik.chakraborty88@yahoo.com;
   biswajit.mukherjee@jadavpuruniversity.in; defeo@unisa.it
RI Dewanjee, Saikat/U-9778-2017; De Feo, Vincenzo/AAF-2293-2019;
   Chakraborty, Pratik/KSM-0591-2024
OI Mukherjee, Prof. Biswajit/0000-0002-7854-9680; Dewanjee,
   Saikat/0000-0001-9085-4226; Chakraborty, Pratik/0000-0002-7880-7854
FU Council of Scientific and Industrial Research, New Delhi, India
   [02(0275)/16/EMR-II]
FX This work was financially supported by Council of Scientific and
   Industrial Research, New Delhi, India, grant number 02(0275)/16/EMR-II
   to S.D.
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NR 361
TC 85
Z9 87
U1 6
U2 43
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD MAR
PY 2020
VL 21
IS 6
AR 2217
DI 10.3390/ijms21062217
PG 44
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA LJ0UU
UT WOS:000529890200313
PM 32210082
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Das, S
   Alhasson, F
   Dattaroy, D
   Pourhoseini, S
   Seth, RK
   Nagarkattit, M
   Nagarkatti, PS
   Michelotti, GA
   Diehl, AM
   Kalyanaraman, B
   Chatterjee, S
AF Das, Suvarthi
   Alhasson, Firas
   Dattaroy, Diptadip
   Pourhoseini, Sahar
   Seth, Ratanesh Kumar
   Nagarkattit, Mitzi
   Nagarkatti, Prakash S.
   Michelotti, Gregory A.
   Diehl, Anna Mae
   Kalyanaraman, Balaraman
   Chatterjee, Saurabh
TI NADPH Oxidase Derived Peroxynitrite Drives Inflammation in Mice and
   Human Nonalcoholic Steatohepatitis via TLR4-Lipid Raft Recruitment
SO AMERICAN JOURNAL OF PATHOLOGY
LA English
DT Article
ID FATTY LIVER-DISEASE; INSULIN-RESISTANCE; OXIDATIVE STRESS; METABOLIC
   SYNDROME; PATHOGENESIS; OBESITY; NASH; MECHANISMS; LIPOPOLYSACCHARIDE;
   ACTIVATION
AB The molecular events that Link NADPH oxidase activation and the induction of Toll-Like receptor (TLR)-4 recruitment into hepatic lipid rafts in nonalcoholic steatohepatitis (NASH) are unclear. We hypothesized that in liver, NADPH oxidase activation is key in TLR4 recruitment into lipid rafts, which in turn up-regulates NF-kappa B translocation to the nucleus and subsequent DNA binding, leading to NASH progression. Results from confocal microscopy showed that liver from murine and human NASH had NADPH oxidase activation, which led to the formation of highly reactive peroxynitrite, as shown by 3-nitrotyrosine formation in diseased liver. Expression and recruitment of TLR4 into the Lipid rafts were significantly greater in rodent and human NASH. The described phenomenon was NADPH oxidase, p47phox, and peroxynitrite dependent, as liver from p47phox-deficient mice and from mice treated with a peroxynitrite decomposition catalyst [iron(III) tetrakis(p-sulfonatophenyl)porphyrin] or a peroxynitrite scavenger (phenylboronic acid) had markedly less Tlr4 recruitment into lipid rafts. Mechanistically, peroxynitrite-induced TLR4 recruitment was linked to increased IL-1 beta, sinusoidal injury, and Kupffer cell activation while blocking peroxynitrite-attenuated NASH symptoms. The results strongly suggest that NADPH oxidase-mediated peroxynitrite drove TLR4 recruitment into hepatic lipid rafts and inflammation, whereas the in vivo use of the peroxynitrite scavenger phenylboronic acid, a novel synthetic molecule having high reactivity with peroxynitrite, attenuates inflammatory pathogenesis in NASH.
C1 [Das, Suvarthi; Alhasson, Firas; Dattaroy, Diptadip; Pourhoseini, Sahar; Seth, Ratanesh Kumar; Chatterjee, Saurabh] Univ S Carolina, Dept Environm Hlth Sci, Environm Hlth & Dis Lab, Columbia, SC 29208 USA.
   [Nagarkattit, Mitzi; Nagarkatti, Prakash S.] Univ S Carolina, Dept Pathol Microbiol & Immunol, Columbia, SC 29208 USA.
   [Michelotti, Gregory A.; Diehl, Anna Mae] Duke Univ, Dept Med, Div Gastroenterol, Durham, NC USA.
   [Kalyanaraman, Balaraman] Med Coll Wisconsin, Free Rad Res Ctr, Dept Biophys, Milwaukee, WI 53226 USA.
C3 University of South Carolina System; University of South Carolina
   Columbia; University of South Carolina System; University of South
   Carolina Columbia; Duke University; Medical College of Wisconsin
RP Chatterjee, S (corresponding author), Univ S Carolina, Dept Environm Hlth Sci, Environm Hlth & Dis Lab, Columbia, SC 29208 USA.
EM schatt@mailbox.sc.edu
RI Alhasson, Firas/KHD-4481-2024; Das, Suvarthi/AAA-4364-2020; Chatterjee,
   Saurabh/JDD-9082-2023; Seth, Ratanesh/M-3700-2016
OI ALhasson, Firas A./0000-0002-4836-516X; Nagarkatti,
   Mitzi/0000-0002-5977-5615; Seth, Ratanesh/0000-0002-7078-0052; ,
   Gregory/0000-0002-3936-4675; Nagarkatti, Prakash/0000-0003-2663-0759
FU NIH Pathway to Independence Award; NIH [R00ES019875, R01DK053792,
   P200M103641, P01AT003961, R01AT006888, R01ES019313, R01MH094755]; VA
   Merit Award [BX001357]
FX Supported by an NIH Pathway to Independence Award (S.C.); NIH grants
   R00ES019875 (S.C.), R01DK053792 (A.M.D.), P200M103641 (S.C., M.N., and
   P.S.N.), and P01AT003961, R01AT006888, R01ES019313, and R01MH094755 (all
   to M.N. and P.S.N.); and VA Merit Award BX001357 (M.N. and P.S.N.).
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NR 52
TC 43
Z9 48
U1 1
U2 19
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0002-9440
EI 1525-2191
J9 AM J PATHOL
JI Am. J. Pathol.
PD JUL
PY 2015
VL 185
IS 7
BP 1944
EP 1957
DI 10.1016/j.ajpath.2015.03.024
PG 14
WC Pathology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pathology
GA CL5KA
UT WOS:000356997600015
PM 25989356
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Tanaka, G
   Yamakoshi, K
   Sawada, Y
   Matsumura, K
   Maeda, K
   Kato, Y
   Horiguchi, M
   Ohguro, H
AF Tanaka, Gohichi
   Yamakoshi, Ken-ichi
   Sawada, Yukihiro
   Matsumura, Kenta
   Maeda, Kimihito
   Kato, Yuichi
   Horiguchi, Masami
   Ohguro, Hiroshi
TI A novel photoplethysmography technique to derive normalized arterial
   stiffness as a blood pressure independent measure in the finger vascular
   bed
SO PHYSIOLOGICAL MEASUREMENT
LA English
DT Article
DE arterial stiffness; small artery and arteriole; pressure-volume
   relationship; finger photoplethysmogram; arteriosclerosis
ID WAVE-FORM ANALYSIS; PHOTOELECTRIC PLETHYSMOGRAPHY; MENTAL STRESS;
   CLINICAL-APPLICATIONS; PERIPHERAL PERFUSION; OSCILLOMETRIC METHOD;
   VOLUME RELATIONSHIP; REACTIVE HYPEREMIA; METABOLIC SYNDROME;
   MENSTRUAL-CYCLE
AB Stiffening of the small artery may be the earliest sign of arteriosclerosis. However, there is no adequate method for directly assessing small arterial stiffness. In this study, the finger arterial elasticity index (FEI) was defined as the parameter n which denotes the curvilinearity of an exponential model of pressure (P)-volume (V-a) relationship (V-a = a - b exp (-nP)). For the original estimation, the FEI was calculated from a compliance index from the finger photoplethysmogram whilst occluding the finger. A simple estimation of the FEI was devised by utilizing normalized pulse volume instead of the compliance index. Both estimations yielded close agreement with the exponential model in healthy young participants (study 1: n = 19). Since the FEI was dependent on finger mean blood pressure, normalized finger arterial stiffness index (FSI) was defined as standardized residual from their relationship: mean and standard deviation (SD) of the FSI were 50 +/- 10 (study 2: n = 174). The mean coefficient of variation of the FSI for four measurements was 5.72% (study 3: n = 6). The mean and SD of the FSI in seven arteriosclerotic patients were 100.0 +/- 13.5. In conclusion, the FEI and FSI by simple estimation are valid and useful for arteriosclerosis research.
C1 [Tanaka, Gohichi; Sawada, Yukihiro; Kato, Yuichi] Sapporo Med Univ, Dept Psychol, Ctr Med Educ, Chuo Ku, Sapporo, Hokkaido 0608556, Japan.
   [Yamakoshi, Ken-ichi] Kanazawa Univ, Grad Sch Nat Sci & Technol, Kanazawa, Ishikawa 9208667, Japan.
   [Matsumura, Kenta] Natl Ctr Neurol & Psychiat, Dept Adult Mental Hlth, Natl Inst Mental Hlth, Tokyo 1878553, Japan.
   [Maeda, Kimihito] Sapporo Med Univ, Sch Med, Dept Ophthalmol, Chuo Ku, Sapporo, Hokkaido 0608556, Japan.
   [Horiguchi, Masami; Ohguro, Hiroshi] Sapporo Med Univ, Sch Hlth Sci, Dept Nursing, Chuo Ku, Sapporo, Hokkaido 0608556, Japan.
C3 Sapporo Medical University; Kanazawa University; National Center for
   Neurology & Psychiatry - Japan; Sapporo Medical University; Sapporo
   Medical University
RP Tanaka, G (corresponding author), Sapporo Med Univ, Dept Psychol, Ctr Med Educ, Chuo Ku, South 1,West 17, Sapporo, Hokkaido 0608556, Japan.
EM gtanaka@sapmed.ac.jp
RI Matsumura, Kenta/ABH-9288-2020; Tanaka, Gohichi/N-3016-2019
OI Matsumura, Kenta/0000-0002-4271-1543
FU Japan Society for the Promotion of Science [21300252]; Grants-in-Aid for
   Scientific Research [21592855, 22570225, 21300252] Funding Source: KAKEN
FX This study was supported in part by a grant-in-aid for Scientific
   Reseach (B) from the Japan Society for the Promotion of Science (grant
   no 21300252) awarded to Gohichi Tanaka. We thank Dr Mark Hamer,
   University College London, UK, for providing suggestions on
   cardiovascular health science.
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NR 47
TC 20
Z9 23
U1 0
U2 17
PU IOP PUBLISHING LTD
PI BRISTOL
PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND
SN 0967-3334
EI 1361-6579
J9 PHYSIOL MEAS
JI Physiol. Meas.
PD NOV
PY 2011
VL 32
IS 11
BP 1869
EP 1883
DI 10.1088/0967-3334/32/11/003
PG 15
WC Biophysics; Engineering, Biomedical; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biophysics; Engineering; Physiology
GA 842BD
UT WOS:000296560200015
PM 22026968
DA 2025-06-11
ER

PT J
AU Németh, Z
   Bukovics, MP
   Sümegi, LD
   Sturm, G
   Takács, I
   Simon-Szabó, L
AF Nemeth, Zsuzsanna
   Bukovics, Mariann Paulinne
   Sumegi, Liza Dalma
   Sturm, Gabor
   Takacs, Istvan
   Simon-Szabo, Laura
TI The Importance of Edible Medicinal Mushrooms and Their Potential Use as
   Therapeutic Agents Against Insulin Resistance
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE medical mushroom; complementary therapy; IR; T2DM; signaling pathway
ID AGARICUS-BLAZEI-MURILL; SUBMERGED MYCELIAL CULTURE; VITAMIN-D
   DEFICIENCY; GUT MICROBIOTA; PLEUROTUS-OSTREATUS; METABOLIC SYNDROME;
   DIABETES-MELLITUS; GRIFOLA-FRONDOSA; MAITAKE MUSHROOM; OXIDATIVE STRESS
AB In addition to conventional treatments, there is growing interest in preventive and complementary therapies. Proper nutrition can prevent the manifestation of several chronic diseases such as obesity, diabetes, cardiovascular disease, and cancer, and can attenuate the severity of these diseases. Edible mushrooms have been used as nutrition and medicine for thousands of years. The spectrum and quantity of their medicinal compounds made them a widely investigated target both in basic research and clinical trials. The most abundant and medically important components are polysaccharides, terpenoids, phenols, and heterocyclic amines, but bioactive proteins, vitamins, including vitamin D, polyunsaturated fatty acids, and essential minerals are also important ingredients with noteworthy health benefits. Mushroom extracts have anti-diabetic, anti-hyperlipidemic, anti-inflammatory, antioxidant, cardioprotective, anti-osteoporotic, and anti-tumor effects and are well tolerated, even by cancer patients. In our previous review we detailed the molecular aspects of the development of type 2 diabetes, discussing the role of physical activity and diet, but we did not detail the role of medicinal mushrooms as part of nutrition. In this review, we aimed to summarize the most important medical mushrooms, along with their natural habitats, growing conditions, and components, that are presumably sufficient for the prevention and treatment of insulin resistance.
C1 [Nemeth, Zsuzsanna; Sumegi, Liza Dalma; Takacs, Istvan] Semmelweis Univ, Dept Internal Med & Oncol, Korany S U 2-A, H-1083 Budapest, Hungary.
   [Sturm, Gabor] Semmelweis Univ, Directorate Informat Technol Basic Infrastruct &, Ullo Ut 78-B, H-1082 Budapest, Hungary.
   [Simon-Szabo, Laura] Semmelweis Univ, Dept Mol Biol, Tuzolto U 37-47, H-1094 Budapest, Hungary.
C3 Semmelweis University; Semmelweis University; Semmelweis University
RP Németh, Z (corresponding author), Semmelweis Univ, Dept Internal Med & Oncol, Korany S U 2-A, H-1083 Budapest, Hungary.
EM nemeth.zsuzsanna@semmelweis.hu; bukovics.mariann0710@gmail.com;
   sumegi.liza.dalma@semmelweis.hu; sturm.gabor@semmelweis.hu;
   takacs.istvan@semmelweis.hu; szabo.laura@semmelweis.hu
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NR 232
TC 0
Z9 0
U1 5
U2 5
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD JAN
PY 2025
VL 26
IS 2
AR 827
DI 10.3390/ijms26020827
PG 27
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA T3V4U
UT WOS:001404324100001
PM 39859540
OA gold
DA 2025-06-11
ER

PT J
AU Shanmugasundaram, S
   Karmakar, S
AF Shanmugasundaram, Shashikiran
   Karmakar, Shaswata
TI Excess dietary sugar and its impact on periodontal inflammation: a
   narrative review
SO BDJ OPEN
LA English
DT Review
ID OXIDATIVE STRESS; ADIPOSE-TISSUE; FRUCTOSE; DISEASE; CONSUMPTION;
   ADDICTION; INTERMITTENT; MICROBIOME; METABOLISM; SUCROSE
AB IntroductionSugar is omnipresent in the current food environment and sugar consumption has drastically risen over the past century. Extensive evidence highlights the negative health consequences of consuming excess dietary sugars, leading the World Health Organization (WHO) and the American Heart Association (AHA) to devise guidelines to restrict sugar intake. According to the WHO's Global Oral Health Status Report of 2022, oral diseases and severe periodontitis are a massive public health problem, and dietary sugars are a modifiable risk factor.MethodsWe conducted a literature review using key databases to summarise the health effects of excessive sugar consumption and their potential role in periodontal inflammation.Results and conclusionAvailable evidence suggests that excess dietary fructose and sucrose can cause low-grade systemic inflammation; and induce dysbiosis in both gut and the oral microbiota. Also, dietary sugar is potentially addictive and hypercaloric and its overconsumption can lead to obesity, metabolic syndrome, and other risk factors for periodontal inflammation. Hence, an unbalanced diet with excess dietary sugars holds the potential to initiate and aggravate periodontal inflammation. In the modern food environment that enables and facilitates a high-sugar diet, adopting a diverse diet and restricting sugar intake according to WHO and AHA guidelines seem beneficial to systemic and periodontal health. Since clinical evidence is limited, future research should study the effectiveness of dietary interventions that control sugar consumption in preventing and managing the global public health problem of periodontal inflammation.
C1 [Shanmugasundaram, Shashikiran; Karmakar, Shaswata] Manipal Acad Higher Educ, Manipal Coll Dent Sci, Dept Periodontol, Manipal, Karnataka, India.
C3 Manipal Academy of Higher Education (MAHE)
RP Shanmugasundaram, S (corresponding author), Manipal Acad Higher Educ, Manipal Coll Dent Sci, Dept Periodontol, Manipal, Karnataka, India.
EM shashi.ks@manipal.edu
RI ; karmakar, shaswata/KFC-0548-2024
OI Kiran. S, Dr. Shashi/0000-0001-9376-260X; karmakar,
   shaswata/0000-0002-7172-0369
FU Manipal Academy of Higher Education, Manipal
FX Open access funding provided by Manipal Academy of Higher Education,
   Manipal.
CR acs, 3d Model of Beta Fructose - American Chemical Society
   acs, 3d Model of Alpha Glucose - American Chemical Society
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ER

PT J
AU Rangraze, IR
   El-Tanani, M
   Rabbani, SA
   Babiker, R
   Matalka, II
   Rizzo, M
AF Rangraze, Imran Rashid
   El-Tanani, Mohamed
   Rabbani, Syed Arman
   Babiker, Rasha
   Matalka, Ismail I.
   Rizzo, Manfredi
TI Diabetes and its Silent Partner: A Critical Review of Hyperinsulinemia
   and its Complications
SO CURRENT DIABETES REVIEWS
LA English
DT Article
DE Hyperinsulinemia; diabetic complications; insulin resistance;
   cardiovascular events; chronic metabolic disorder; diabetes mellitus
ID OBSTRUCTIVE SLEEP-APNEA; INSULIN-RESISTANCE; CARDIOVASCULAR-DISEASE;
   OXIDATIVE STRESS; LIFE-STYLE; METABOLIC SYNDROME; NITRIC-OXIDE;
   RISK-FACTOR; MELLITUS; MECHANISMS
AB In this complex realm of diabetes, hyperinsulinemia is no longer regarded as just a compensatory response to insulin resistance but rather has evolved into an integral feature. This comprehensive review provides a synthesis of the current literature, including various aspects associated with hyperinsulinemia in diabetic complications. Hyperinsulinemia has been shown to be more than just a compensatory mechanism, and the key findings demonstrate how hyperinsulinism affects the development of cardiovascular events as well as microvascular complications. Additionally, recognizing hyperinsulinemia as a modifiable factor, the diabetes management paradigm shifts towards cognitive ones that consider the use of lifestyle modifications in combination with newer pharmacotherapies and precision medicine approaches. These findings have crucial implications for the clinical work, requiring a careful appreciation of hyperinsulinemia's changing aspects as well as incorporation in personalized treatment protocol. In addition, the review focuses on bigger issues related to public health, showing that prevention and early diagnosis will help reduce the burden of complications. Research implications favor longitudinal studies, biomarker discovery, and the study of emerging treatment modalities; clinical practice should adopt global evaluations, patient education, and precision medicine adaptation. Finally, this critical review provides an overview of the underlying processes of hyperinsulinemia in diabetes and its overall health effects.
C1 [Rangraze, Imran Rashid] RAK Med & Hlth Sci Univ, RAK Coll Med Sci, Internal Med Dept, Rasal Khaimah, U Arab Emirates.
   [El-Tanani, Mohamed; Rabbani, Syed Arman] Ras Al Khaimah Med & Hlth Sci Univ, Coll Pharm, Ras Al Khaymah, U Arab Emirates.
   [Babiker, Rasha] RAK Med & Hlth Sci Univ, RAK Coll Med Sci, Physiol Dept, Ras Al Khaymah, U Arab Emirates.
   [Matalka, Ismail I.] Ras Al Khaimah Med & Hlth Sci Univ, Ras Al Khaymah, U Arab Emirates.
   [Rizzo, Manfredi] Univ Palermo, Sch Med, Dept Hlth Promot Mother & Childcare Internal Med &, Palermo, Italy.
C3 University of Palermo
RP El-Tanani, M (corresponding author), Ras Al Khaimah Med & Hlth Sci Univ, Coll Pharm, Ras Al Khaymah, U Arab Emirates.
EM eltanani@rakmhsu.ac.ae
RI BABIKER, RASHA/AAP-3054-2020; Rabbani, Dr Syed/AGC-7019-2022; RIZZO,
   MANFREDI/GZL-0551-2022; Rangraze, Imran/AAD-1103-2019
FX Declared none.
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   Zhao XF, 2023, FRONT ENDOCRINOL, V14, DOI 10.3389/fendo.2023.1149239
NR 166
TC 1
Z9 1
U1 4
U2 6
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1573-3998
EI 1875-6417
J9 CURR DIABETES REV
JI Curr. Diabetes Reviews
PY 2025
VL 21
IS 9
DI 10.2174/0115733998311738240813110032
EA AUG 2024
PG 18
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA Z4B8H
UT WOS:001310050800001
PM 39192649
DA 2025-06-11
ER

PT J
AU Li, D
   Liu, YX
   Hui, YM
   Li, B
   Hao, CF
AF Li, Duan
   Liu, Yingxue
   Hui, Yameng
   Li, Bing
   Hao, Cuifang
TI A Glimpse of Research Trends and Frontiers in the Etiology of Premature
   Ovarian Insufficiency via Bibliometric Analysis
SO ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS
LA English
DT Review
DE Premature ovarian insufficiency; pathogenesis; etiology; bibliometric
   analysis; VOSviewer; etiology research
ID METABOLIC SYNDROME; CHILDHOOD-CANCER; MENOPAUSE; WOMEN; AGE;
   CHILDBEARING; POPULATION; PREVALENCE; SAMPLE; CHINA
AB Introduction Premature Ovarian Insufficiency (POI) is the most common reproductive aging disorder in women of reproductive age, which is characterized by decreased ovarian function in women before the age of 40. Etiology research of POI has garnered interest and attention from scholars worldwide over the past decades. Methods However, to the best of our knowledge, no comprehensive survey with bibliometric analysis has been conducted yet on the research trends of POI etiology. This article aimed to analyze current scientific findings on the etiology of POI, offering innovative ideas for further research. Research articles on the etiology of POI from 1994 to 2023 were collected from the Web of Science Core Collection. A total of 456 research articles were included, and the total number of publications increased annually. We used VOSviewer and bibliometric.com to analyze the keywords, terms, institution, publication country/region, author name, publication journal, and the sum of times the articles have been cited. Results This study has shown that a research hotspot is the genetic etiology of POI; however, there is still a lack of research on the impact of epigenetic alterations, iatrogenic injuries, environmental pollution, social stress, and unhealthy lifestyles on the pathogenesis of POI. Conclusion The factors illustrated here represent potential future directions for POI etiology research and warrant more attention from researchers.
C1 [Li, Duan; Liu, Yingxue; Hao, Cuifang] Qingdao Univ, Women & Childrens Hosp, Ctr Reprod Med, Qingdao, Peoples R China.
   [Li, Duan; Liu, Yingxue; Hao, Cuifang] Branch Shandong Prov Clin Res Ctr Reprod Hlth, Qingdao, Peoples R China.
   [Li, Duan; Liu, Yingxue; Hao, Cuifang] Qingdao Univ, Coll Med, Qingdao, Peoples R China.
   [Li, Duan; Li, Bing] Qingdao Univ, Basic Med Coll, Dept Genet & Cell Biol, Qingdao, Peoples R China.
   [Hui, Yameng] Univ Hlth & Rehabil Sci, Qingdao Cent Hosp, Qingdao, Peoples R China.
C3 Qingdao University; Qingdao University; Qingdao University; University
   of Health & Rehabilitation Sciences
RP Hao, CF (corresponding author), Qingdao Univ, Women & Childrens Hosp, Ctr Reprod Med, Qingdao, Peoples R China.; Hao, CF (corresponding author), Branch Shandong Prov Clin Res Ctr Reprod Hlth, Qingdao, Peoples R China.; Hao, CF (corresponding author), Qingdao Univ, Coll Med, Qingdao, Peoples R China.; Li, B (corresponding author), Qingdao Univ, Basic Med Coll, Dept Genet & Cell Biol, Qingdao, Peoples R China.
EM cuifang-hao@163.com; libing_516@qdu.edu.cn
OI Li, Duan/0000-0001-9393-167X
FU National Natural Science Foundation of China [82201801, 81671416]; Key
   Clinical Specialty of Qingdao, China -Special Fund for the
   Technology-Benefiting-People Project of Qingdao, China
   [23-2-8-smjk-16-nsh]
FX This work was supported by The National Natural Science Foundation of
   China (No. 82201801 and 81671416) and Key Clinical Specialty of Qingdao,
   China -Special Fund for the Technology-Benefiting-People Project of
   Qingdao, China (No. 23-2-8-smjk-16-nsh).
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NR 95
TC 0
Z9 0
U1 9
U2 17
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1871-5303
EI 2212-3873
J9 ENDOCR METAB IMMUNE
JI Endocr. Metab. Immune Disord.-Drug Targets
PY 2025
VL 25
IS 4
BP 310
EP 325
DI 10.2174/0118715303313887240624071238
EA JUN 2024
PG 16
WC Endocrinology & Metabolism; Immunology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Immunology; Pharmacology & Pharmacy
GA W5R6C
UT WOS:001299809000001
PM 38919087
OA hybrid
DA 2025-06-11
ER

PT J
AU Liao, FF
   Lin, G
   Chen, XY
   Chen, L
   Zheng, W
   Raghow, R
   Zhou, FM
   Shih, AY
   Tan, XL
AF Liao, Francesca-Fang
   Lin, Geng
   Chen, Xingyong
   Chen, Ling
   Zheng, Wei
   Raghow, Rajendra
   Zhou, Fu-Ming
   Shih, Andy Y.
   Tan, Xing-Lin
TI Endothelial Nitric Oxide Synthase-Deficient Mice A Model of
   Spontaneous Cerebral Small-Vessel Disease
SO AMERICAN JOURNAL OF PATHOLOGY
LA English
DT Review
ID BLOOD-BRAIN-BARRIER; WHITE-MATTER; ALZHEIMERS-DISEASE; TRANSFORMING
   GROWTH-FACTOR-BETA-1; OLIGODENDROGLIAL LINEAGE; GENE POLYMORPHISMS;
   METABOLIC SYNDROME; PYRAMIDAL NEURONS; LACUNAR STROKE; RODENT MODELS
AB Age-related cerebral small-vessel disease (CSVD) is a major cause of stroke and dementia. Despite a widespread acceptance of small-vessel arteriopathy, lacunar infarction, diffuse white matter injury, and cognitive impairment as four cardinal features of CSVD, a unifying pathologic mechanism of CSVD remains elusive. Herein, we introduce partial endothelial nitric oxide synthase (eNOS)-deficient mice as a model of age-dependent, spontaneous CSVD. These mice developed cerebral hypoperfusion and blood-brain barrier leakage at a young age, which progressively worsened with advanced age. Their brains exhibited elevated oxidative stress, astrogliosis, cerebral amyloid angiopathy, microbleeds, microinfarction, and white matter pathology. Partial eNOS-deficient mice developed gait disturbances at middle age, and hippocampus-dependent memory deficits at older ages. These mice also showed enhanced expression of bone morphogenetic protein 4 (BMP4) in brain pericytes before myelin loss and white matter pathology. Because BMP4 signaling not only promotes astrogliogenesis but also blocks oligodendrocyte differentiation, we posit that paracrine actions of BMP4, localized within the neurovascular unit, promote white matter disorganization and neurodegeneration. These observations point to BMP4 signaling pathway in the aging brain vasculature as a potential therapeutic target. Finally, because studies in partial eNOS-deficient mice corroborated recent clinical evidence that blood-brain barrier disruption is a primary cause of white matter pathology, the mechanism of impaired nitric oxide signaling-mediated CSVD warrants further investigation.
C1 [Liao, Francesca-Fang; Lin, Geng; Chen, Xingyong; Chen, Ling; Zheng, Wei; Raghow, Rajendra; Zhou, Fu-Ming; Tan, Xing-Lin] Univ Tennessee, Coll Med, Hlth Sci Ctr, Dept Pharmacol,Addict Sci,Toxicol, Memphis, TN USA.
   [Lin, Geng; Zheng, Wei] China Med Univ, Basic Med Univ, Dept Histol & Embryol, Shenyang, Peoples R China.
   [Chen, Xingyong] Fujian Med Univ, Prov Clin Coll, Fujian Prov Hosp, Dept Neurol, Fuzhou, Peoples R China.
   [Chen, Ling] Fujian Med Univ, Sch Basic Med Sci, Dept Cell Biol & Genet, Fuzhou, Peoples R China.
   [Shih, Andy Y.] Seattle Childrens Res Inst, Seattle, WA USA.
   [Tan, Xing-Lin] Southern Med Univ, Nanhai Hosp, Dept Neurol, Foshan, Peoples R China.
C3 University of Tennessee System; University of Tennessee Health Science
   Center; China Medical University; Fujian Provincial Hospital; Fujian
   Medical University; Fujian Medical University; Seattle Children's
   Hospital; Southern Medical University - China
RP Liao, FF (corresponding author), 71 S Manassas St, Memphis, TN 38163 USA.
EM fliao@uthse.edu
RI Chen, Lingling/JCD-4631-2023
FU National Institute on Aging [R01NS097775] Funding Source: NIH RePORTER
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NR 100
TC 34
Z9 38
U1 0
U2 9
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0002-9440
EI 1525-2191
J9 AM J PATHOL
JI Am. J. Pathol.
PD NOV
PY 2021
VL 191
IS 11
BP 1932
EP 1945
DI 10.1016/j.ajpath.2021.02.022
EA OCT 2021
PG 14
WC Pathology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pathology
GA WN1WR
UT WOS:000711566600009
PM 33711310
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Gorabi, AM
   Aslani, S
   Imani, D
   Razi, B
   Sathyapalan, T
   Sahebkar, A
AF Gorabi, Armita Mahdavi
   Aslani, Saeed
   Imani, Danyal
   Razi, Bahman
   Sathyapalan, Thozhukat
   Sahebkar, Amirhossein
TI Effect of resveratrol on C-reactive protein: An updated meta-analysis of
   randomized controlled trials
SO PHYTOTHERAPY RESEARCH
LA English
DT Review
DE CRP; hs-CRP; inflammation; meta-analysis; randomized clinical trial;
   resveratrol
ID BLOOD MONONUCLEAR-CELLS; DOUBLE-BLIND; CLINICAL-TRIAL; METABOLIC
   SYNDROME; OXIDATIVE STRESS; SUPPLEMENTATION; IMPROVES; EXPRESSION;
   INFLAMMATION; PREVENTS
AB We conducted a meta-analysis on the available randomized clinical trials (RCTs) to assess the role of resveratrol in lowering C-reactive protein (CRP) and high-sensitivity CRP (hs-CRP) levels, as markers of inflammation, in various inflammatory disorders. Literature search through Medline/PubMed, Scopus, ISI Web of Science, and Cochrane Library yielded 35 RCTs (24 studies for hs-CRP and 11 studies for CRP). Pooled results revealed that resveratrol supplementation significantly reduced the hs-CRP (MWD = -0.40 mg/L; 95% CI: -0.70 to -0.09 mg/L; p = .01) and CRP (MWD = -0.31 mg/L; 95% CI: -0.47 to -0.15 mg/L; p < .001) levels in serum. Subgroup analysis revealed that resveratrol in group with >= 10 weeks significantly reduces hs-CRP levels (MWD = -0.48 mg/L; 95% CI: -0.92 to -0.04 mg/L; p = .03) and CRP (WMD = -0.47 mg/L, 95% CI = -0.69 to -0.25, p < .001). A dose of >= 500 mg/day supplementation improves the levels of CRP, but not hs-CRP. This meta-analysis demonstrates that resveratrol consumption is effective in lowering the levels of CRP and hs-CRP in inflammatory conditions, especially if supplementation takes place for >= 10 weeks with >= 500 mg/day.
C1 [Gorabi, Armita Mahdavi] Univ Tehran Med Sci, Res Ctr Adv Technol Cardiovasc Med, Tehran Heart Ctr, Tehran, Iran.
   [Aslani, Saeed] Univ Tehran Med Sci, Sch Med, Dept Immunol, Tehran, Iran.
   [Imani, Danyal] Univ Tehran Med Sci, Sch Publ Hlth, Dept Immunol, Tehran, Iran.
   [Razi, Bahman] Tarbiat Modares Univ, Dept Hematol, Fac Med Sci, Tehran, Iran.
   [Sathyapalan, Thozhukat] Univ Hull, Acad Diabet Endocrinol & Metab, Hull York Med Sch, Kingston Upon Hull, N Humberside, England.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Biotechnol Res Ctr, Mashhad, Razavi Khorasan, Iran.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Appl Biomed Res Ctr, Mashhad, Razavi Khorasan, Iran.
   [Sahebkar, Amirhossein] Univ Western Australia, Sch Med, Perth, Australia.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Sch Pharm, Mashhad, Razavi Khorasan, Iran.
C3 Tehran University of Medical Sciences; Tehran University of Medical
   Sciences; Tehran University of Medical Sciences; Tarbiat Modares
   University; University of Hull; University of York - UK; Mashhad
   University of Medical Sciences; Mashhad University of Medical Sciences;
   University of Western Australia; Mashhad University of Medical Sciences
RP Sahebkar, A (corresponding author), Mashhad Univ Med Sci, Sch Med, Dept Med Biotechnol, POB 91779-48564, Mashhad, Razavi Khorasan, Iran.; Razi, B (corresponding author), Tarbiat Modares Univ, Sch Med, Dept Hematol & Blood transfus, North Kargar Ave, Tehran 14117, Iran.
EM razib@yandex.com; sahebkara@mums.ac.ir
RI Sahebkar, Amirhossein/B-5124-2018; Sathyapalan, Thozhukat/J-5212-2012;
   Razi, Bahman/HCI-8979-2022; Aslani, Saeed/AAV-6835-2020
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NR 70
TC 13
Z9 14
U1 1
U2 9
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0951-418X
EI 1099-1573
J9 PHYTOTHER RES
JI Phytother. Res.
PD DEC
PY 2021
VL 35
IS 12
BP 6754
EP 6767
DI 10.1002/ptr.7262
EA SEP 2021
PG 14
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA XS4FK
UT WOS:000693203500001
PM 34472150
DA 2025-06-11
ER

PT J
AU Shukitt-Hale, B
   Thangthaeng, N
   Miller, MG
   Poulose, SM
   Carey, AN
   Fisher, DR
AF Shukitt-Hale, Barbara
   Thangthaeng, Nopporn
   Miller, Marshall G.
   Poulose, Shibu M.
   Carey, Amanda N.
   Fisher, Derek R.
TI Blueberries Improve Neuroinflammation and Cognition differentially
   Depending on Individual Cognitive baseline Status
SO JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL
   SCIENCES
LA English
DT Article; Proceedings Paper
CT Symposium on Blue Versus Gray - Potential Health Benefits of Blueberries
   for Successful Aging held at the International Congress of Gerontology
CY JUL 27, 2017
CL San Francisco, CA
DE Behavior; Antioxidant; Anti-inflammatory; Learning; Memory
ID AGE-RELATED DECLINES; DIETARY SUPPLEMENTATION; SYSTEMIC INFLAMMATION;
   BEHAVIORAL DEFICITS; METABOLIC SYNDROME; NEURONAL FUNCTION;
   WORKING-MEMORY; RATS; MOTOR; STRESS
AB Daily supplementation of blueberries (BBs) reverses age-related deficits in behavior in aged rats. However, it is unknown whether BB is more beneficial to one subset of the population dependent on baseline cognitive performance and inflammatory status. To examine the effect of individual differences on the efficacy of BB, aged rats (17 months old) were assessed for cognition in the radial arm water maze (RAWM) and divided into good, average, and poor performers based on navigation errors. Half of the rats in each cognitive group were then fed a control or a 2% BB diet for 8 weeks before retesting. Serum samples were collected, pre-diet and post-diet, to assess inflammation. Latency in the radial arm water maze was significantly reduced in the BB-fed poor performers (p < .05) and preserved in the BB-fed good performers. The control-fed good performers committed more working and reference memory errors in the post-test than pretest (p < .05), whereas the BB-fed good performers showed no change. An in vitro study using the serum showed that BB supplementation attenuated lipopolysaccharide (LPS)induced nitrite and tumor necrosis factor-alpha, and cognitive performance was associated with innate anti-inflammatory capability. Therefore, consumption of BB may reverse some age-related deficits in cognition, as well as preserve function among those with intact cognitive ability.
C1 [Shukitt-Hale, Barbara; Thangthaeng, Nopporn; Miller, Marshall G.; Poulose, Shibu M.; Carey, Amanda N.; Fisher, Derek R.] Tufts Univ, USDA ARS, Human Nutr Res Ctr Aging, Boston, MA 02111 USA.
C3 Tufts University; United States Department of Agriculture (USDA)
RP Shukitt-Hale, B (corresponding author), Tufts Univ, USDA ARS, Neurosci & Aging Lab, Human Nutr Res Ctr Aging, 711 Washington St, Boston, MA 02111 USA.
EM barbara.shukitthale@ars.usda.gov
OI Shukitt-Hale, Barbara/0000-0002-3810-1910
FU USDA Intramural funds; National Institute on Aging [T32-AG000029]
FX This research was supported by USDA Intramural funds. The blueberry
   powder used in this study was provided at no cost under a Material
   Transfer Agreement between the USDA and the U.S. Highbush Blueberry
   Council (USHBC). Dr. Miller received partial support from the National
   Institute on Aging (T32-AG000029).
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NR 49
TC 12
Z9 14
U1 0
U2 8
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1079-5006
EI 1758-535X
J9 J GERONTOL A-BIOL
JI J. Gerontol. Ser. A-Biol. Sci. Med. Sci.
PD JUL
PY 2019
VL 74
IS 7
BP 977
EP 983
DI 10.1093/gerona/glz048
PG 7
WC Geriatrics & Gerontology; Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI); Conference Proceedings Citation Index - Science (CPCI-S); Conference Proceedings Citation Index - Social Science &amp; Humanities (CPCI-SSH)
SC Geriatrics & Gerontology
GA IG4NI
UT WOS:000473779900003
PM 30772901
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Teng, CF
   Hsieh, WC
   Wu, HC
   Lin, YJ
   Tsai, HW
   Huang, WY
   Su, IJ
AF Teng, Chiao-Fang
   Hsieh, Wen-Chuan
   Wu, Han-Chieh
   Lin, Yih-Jyh
   Tsai, Hung-Wen
   Huang, Wenya
   Su, Ih-Jen
TI Hepatitis B Virus Pre-S2 Mutant Induces Aerobic Glycolysis through
   Mammalian Target of Rapamycin Signal Cascade
SO PLOS ONE
LA English
DT Article
ID GROUND-GLASS HEPATOCYTES; CANCER-CELL METABOLISM;
   HEPATOCELLULAR-CARCINOMA; C-MYC; TISSUE METABOLOMICS; TRANSGENIC MICE;
   X-PROTEIN; S MUTANTS; MTOR; EXPRESSION
AB Hepatitis B virus (HBV) pre-S2 mutant can induce hepatocellular carcinoma (HCC) via the induction of endoplasmic reticulum stress to activate mammalian target of rapamycin (MTOR) signaling. The association of metabolic syndrome with HBV-related HCC raises the possibility that pre-S2 mutant-induced MTOR activation may drive the development of metabolic disorders to promote tumorigenesis in chronic HBV infection. To address this issue, glucose metabolism and gene expression profiles were analyzed in transgenic mice livers harboring pre-S2 mutant and in an in vitro culture system. The pre-S2 mutant transgenic HCCs showed glycogen depletion. The pre-S2 mutant initiated an MTOR-dependent glycolytic pathway, involving the eukaryotic translation initiation factor 4E binding protein 1 (EIF4EBP1), Yin Yang 1 (YY1), and myelocytomatosis oncogene (MYC) to activate the solute carrier family 2 (facilitated glucose transporter), member 1 (SLC2A1), contributing to aberrant glucose uptake and lactate production at the advanced stage of pre-S2 mutant transgenic tumorigenesis. Such a glycolysis-associated MTOR signal cascade was validated in human HBV-related HCC tissues and shown to mediate the inhibitory effect of a model of combined resveratrol and silymarin product on tumor growth. Our results provide the mechanism of pre-S2 mutant-induced MTOR activation in the metabolic switch in HBV tumorigenesis. Chemoprevention can be designed along this line to prevent HCC development in high-risk HBV carriers.
C1 [Teng, Chiao-Fang; Hsieh, Wen-Chuan; Wu, Han-Chieh; Su, Ih-Jen] Natl Hlth Res Inst, Natl Inst Infect Dis & Vaccinol, Tainan, Taiwan.
   [Lin, Yih-Jyh; Su, Ih-Jen] Natl Cheng Kung Univ Hosp, Dept Surg, Tainan 70428, Taiwan.
   [Tsai, Hung-Wen; Su, Ih-Jen] Natl Cheng Kung Univ Hosp, Dept Pathol, Tainan 70428, Taiwan.
   [Huang, Wenya] Natl Cheng Kung Univ, Coll Med, Dept Med Lab Sci & Biotechnol, Tainan 70101, Taiwan.
C3 National Health Research Institutes - Taiwan; National Cheng Kung
   University; National Cheng Kung University Hospital; National Cheng Kung
   University; National Cheng Kung University Hospital; National Cheng Kung
   University
RP Su, IJ (corresponding author), Natl Hlth Res Inst, Natl Inst Infect Dis & Vaccinol, Tainan, Taiwan.
EM suihjen@nhri.org.tw
RI Teng, Chiao-Fang/L-6679-2013; Su, Ih-Jen/B-2655-2010; Huang,
   Wenya/G-9115-2011; Wu, Han-Chieh/K-6928-2013
OI Teng, Chiao-Fang/0000-0002-5218-0571; Wu, Han-Chieh/0000-0003-2638-7883
FU National Health Research Institutes [03A1-IVPP20-014]
FX The authors received a grant from National Health Research Institutes
   (grant number: 03A1-IVPP20-014;
   http://www.nhri.org.tw/NHRI_WEB/nhriw001Action. do). The funders had no
   role in study design, data collection and analysis, decision to publish,
   or preparation of the manuscript.
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NR 37
TC 56
Z9 59
U1 1
U2 11
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD APR 24
PY 2015
VL 10
IS 4
AR e0122373
DI 10.1371/journal.pone.0122373
PG 17
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA CG6AH
UT WOS:000353376800020
PM 25909713
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Chung, S
   Ranjan, R
   Lee, YG
   Park, GY
   Karpurapu, M
   Deng, J
   Xiao, L
   Kim, JY
   Unterman, TG
   Christman, JW
AF Chung, Sangwoon
   Ranjan, Ravi
   Lee, Yong Gyu
   Park, Gye Young
   Karpurapu, Manjula
   Deng, Jing
   Xiao, Lei
   Kim, Ji Young
   Unterman, Terry G.
   Christman, John W.
TI Distinct role of FoxO1 in M-CSF- and GM-CSF-differentiated macrophages
   contributes LPS-mediated IL-10: implication in hyperglycemia
SO JOURNAL OF LEUKOCYTE BIOLOGY
LA English
DT Article
DE monocyte; metabolic stress; M1-like; M2-like; inflammation
ID NF-KAPPA-B; COLONY-STIMULATING FACTOR; HIGH-FAT-DIET;
   INSULIN-RESISTANCE; ADIPOSE-TISSUE; TRANSCRIPTION FACTORS; ALTERNATIVE
   ACTIVATION; INDUCED INFLAMMATION; METABOLIC SYNDROME; LUNG INFLAMMATION
AB Macrophages are a heterogeneous population of immune cells that are essential for the initiation and containment inflammation. There are 2 well-established populations of inflammatory macrophages: classically activated M1 and alternatively activated M2 macrophages. The FoxO family of transcription factors plays key roles in a number of cellular processes, including cell growth, metabolism, survival, and inflammation. In this study, we determined whether the expression of FoxO1 contributes polarization of macrophages toward the M2-like phenotype by enhancing IL-10 cytokine expression. We identified that FoxO1 is highly expressed in M-CSF-derived (M2-like) macrophage subsets, and this M2-like macrophages showed a preferential FoxO1 enrichment on the IL-10 promoter but not in GM-CSF-derived (M1-like) macrophages during classic activation by LPS treatment, which suggests that FoxO1 enhances IL-10 by binding directly to the IL-10 promoter, especially in BMMs. In addition, our data show that macrophages in the setting of hyperglycemia contribute to the macrophage-inflammatory phenotype through attenuation of the contribution of FoxO1 to activate IL-10 expression. Our data identify a novel role for FoxO1 in regulating IL-10 secretion during classic activation and highlight the potential for therapeutic interventions for chronic inflammatory conditions, such as atherosclerosis, diabetes, inflammatory bowel disease, and arthritis.
C1 [Chung, Sangwoon; Lee, Yong Gyu; Karpurapu, Manjula; Deng, Jing; Kim, Ji Young; Christman, John W.] Ohio State Univ, Div Pulm Allergy Crit Care & Sleep, Dept Internal Med, Columbus, OH 43210 USA.
   [Ranjan, Ravi; Park, Gye Young; Xiao, Lei] Univ Illinois, Dept Med, Sect Pulm Crit Care Sleep & Allergy, Chicago, IL USA.
   [Unterman, Terry G.; Christman, John W.] Jesse Brown Vet Affairs Med Ctr, Chicago, IL USA.
C3 University System of Ohio; Ohio State University; University of Illinois
   System; University of Illinois Chicago; University of Illinois Chicago
   Hospital; US Department of Veterans Affairs; Veterans Health
   Administration (VHA); Jesse Brown VA Medical Center
RP Christman, JW (corresponding author), Ohio State Univ, Div Pulm Allergy Crit Care & Sleep, Dept Internal Med, Davis Heart & Lung Res Inst 201, 473 West 12th Ave, Columbus, OH 43210 USA.
EM John.Christman@osumc.edu
RI Kim, Ji/AAN-5655-2021; Ranjan, Ravi/D-1614-2016
OI Ranjan, Ravi/0000-0002-8768-549X; CHRISTMAN, JOHN/0000-0001-6926-9313
FU U.S. National Institutes of Health [2R01HL075557-08, 5R01HL103643-03];
   U.S. Department of Veterans Affairs Merit Review Grant [5I01BX000108]
FX This work was supported by U.S. National Institutes of Health Grants
   2R01HL075557-08 and 5R01HL103643-03 and U.S. Department of Veterans
   Affairs Merit Review Grant 5I01BX000108. The authors thank Dr. Jaehyung
   Cho for support with human PBMC experiments. The authors gratefully
   acknowledge Drs. Timothy Koh and Aaron J. Trask for providing bone
   marrow from the db/db mice.
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NR 76
TC 67
Z9 72
U1 2
U2 24
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0741-5400
EI 1938-3673
J9 J LEUKOCYTE BIOL
JI J. Leukoc. Biol.
PD FEB
PY 2015
VL 97
IS 2
BP 327
EP 339
DI 10.1189/jlb.3A0514-251R
PG 13
WC Cell Biology; Hematology; Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Hematology; Immunology
GA CB2GB
UT WOS:000349443900014
PM 25420919
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Lu, XF
   Liu, Y
   Kong, XJ
   Lobie, PE
   Chen, CY
   Zhu, T
AF Lu, Xuefei
   Liu, Ying
   Kong, Xiangjun
   Lobie, Peter E.
   Chen, Chunying
   Zhu, Tao
TI Nanotoxicity: A Growing Need for Study in the Endocrine System
SO SMALL
LA English
DT Review
DE nanoparticles; nanotoxicity; endocrine system; nanomaterials
ID ACUTE REGULATORY PROTEIN; DIESEL EXHAUST PARTICLES; MALE
   REPRODUCTIVE-SYSTEM; WALL CARBON NANOTUBES; SILVER NANOPARTICLES;
   QUANTUM DOTS; OXIDATIVE STRESS; CYTOCHROME-P450 ENZYMES; TESTICULAR
   FUNCTION; PRISTINE GRAPHENE
AB Nanomaterials (NMs) are engineered for commercial purposes such as semiconductors, building materials, cosmetics, and drug carriers, while natural nanoparticles (NPs) already exist in the environment. Due to their unique physicochemical properties, they may interact actively with biological systems. Some of these interactions might be detrimental to human health, and therefore studies on the potential nanotoxicity' of these materials in different organ systems are warranted. The purpose of developing the concept of nanotoxicity is to recognize and evaluate the hazards and risks of NMs and evaluate safety. This review will summarize and discuss recent reports derived from cell lines or animal models concerning the effects of NMs on, and their application in, the endocrine system of mammalian and other species. It will present an update on current studies of the effects of some typical NMssuch as metal-based NMs, carbon-based NMs, and dendrimerson endocrine functions, in which some effects are adverse or unwanted and others are favorable or intended. Disruption of endocrine function is associated with adverse health outcomes including reproductive failure, metabolic syndrome, and some types of cancer. Further investigations are therefore required to obtain a thorough understanding of any potential risk of pathological endocrine disruption from products containing NMs. This review aims to provide impetus for further studies on the interactions of NMs with endocrine functions.
C1 [Lu, Xuefei; Kong, Xiangjun; Zhu, Tao] Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, Hefei 230026, Anhui, Peoples R China.
   [Lu, Xuefei; Kong, Xiangjun; Zhu, Tao] Univ Sci & Technol China, Sch Life Sci, Hefei 230026, Anhui, Peoples R China.
   [Liu, Ying; Chen, Chunying] Chinese Acad Sci, Key Lab Biomed Effects Nanomat & Nanosafety, Natl Ctr Nanosci & Technol China, Beijing 100190, Peoples R China.
   [Lobie, Peter E.] Natl Univ Singapore, Canc Sci Inst Singapore, Singapore 117456, Singapore.
   [Lobie, Peter E.] Natl Univ Singapore, Dept Pharmacol, Singapore 117456, Singapore.
C3 Chinese Academy of Sciences; University of Science & Technology of
   China, CAS; Chinese Academy of Sciences; University of Science &
   Technology of China, CAS; Chinese Academy of Sciences; National Center
   for Nanoscience & Technology, CAS; Key Laboratory for Biological Effects
   of Nanomaterials & Nanosafety, CAS; National University of Singapore;
   National University of Singapore
RP Chen, CY (corresponding author), Chinese Acad Sci, Key Lab Biomed Effects Nanomat & Nanosafety, Natl Ctr Nanosci & Technol China, Beijing 100190, Peoples R China.
EM chenchy@nanoctr.cn; zhut@ustc.edu.cn
RI Liu, Ying/HMD-5234-2023; Chen, Chunying/AAA-2891-2021; Zhu,
   Tao/H-3495-2018
OI Chen, Chunying/0000-0002-6027-0315; Liu, Ying/0000-0002-6540-0473
FU Ministry of Science and Technology of the People's Republic of China
   [2012CB934000, 2011CB933401, 2010CB912804]; National Natural Science
   Foundation of China [21001034, 10975040, 81272925, 30971492]; Cancer
   Science Institute of Singapore and the Senior Foreign Expert Plan
   [GDW20123400151]
FX This work was financially supported by the Ministry of Science and
   Technology of the People's Republic of China (2012CB934000,
   2011CB933401, and 2010CB912804), the National Natural Science Foundation
   of China (21001034, 10975040, 81272925 and 30971492) and Cancer Science
   Institute of Singapore and the Senior Foreign Expert Plan
   (GDW20123400151).
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NR 119
TC 65
Z9 68
U1 2
U2 138
PU WILEY-V C H VERLAG GMBH
PI WEINHEIM
PA POSTFACH 101161, 69451 WEINHEIM, GERMANY
SN 1613-6810
EI 1613-6829
J9 SMALL
JI Small
PD MAY 27
PY 2013
VL 9
IS 9-10
SI SI
BP 1654
EP 1671
DI 10.1002/smll.201201517
PG 18
WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience &
   Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied;
   Physics, Condensed Matter
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Science & Technology - Other Topics; Materials Science;
   Physics
GA 146FT
UT WOS:000319076000019
PM 23401134
DA 2025-06-11
ER

PT J
AU Xie, XT
   Yi, ZP
   Bowen, B
   Wolf, C
   Flynn, CR
   Sinha, S
   Mandarino, LJ
   Meyer, C
AF Xie, Xitao
   Yi, Zhengping
   Bowen, Benjamin
   Wolf, Cassandra
   Flynn, Charles R.
   Sinha, Sandeep
   Mandarino, Lawrence J.
   Meyer, Christian
TI Characterization of the Human Adipocyte Proteome and Reproducibility of
   Protein Abundance by One-Dimensional Gel Electrophoresis and
   HPLC-ESI-MS/MS
SO JOURNAL OF PROTEOME RESEARCH
LA English
DT Article
DE adipocyte; mitochondria; proteomics; human
ID VISCERAL ADIPOSE-TISSUE; LIPID DROPLETS; GENE-EXPRESSION; MITOCHONDRIAL
   BIOGENESIS; SKELETAL-MUSCLE; FAT; OBESITY; CELLS; ADIPOGENESIS;
   METABOLISM
AB Abnormalities in adipocytes play an important role in various conditions, including the metabolic syndrome, type 2 diabetes mellitus and cardiovascular disease, but little is known about alterations at the protein level. We therefore sought to (1) comprehensively characterize the human adipocyte proteome for the first time and (2) demonstrate feasibility of measuring adipocyte protein abundances by one-dimensional SDS-PAGE and high performance liquid chromatography-electron spray ionization-tandem mass spectrometry (HPLC-ESI-MS/MS). In adipocytes isolated from similar to 0.5 g of subcutaneous abdominal adipose tissue of three healthy, lean subjects, we identified a total of 1493 proteins. Triplicate analysis indicated a 22.5% coefficient of variation of protein abundances. Proteins ranged from 5.8 to 629 kDa and included a large number of proteins involved in lipid metabolism, such as fatty acid transport, fatty acid oxidation, lipid storage, lipolysis, and lipid droplet maintenance. Furthermore, we found most glycolysis enzymes and numerous proteins associated with oxidative stress, protein synthesis and degradation as well as some adipokines. 22% of all proteins were of mitochondrial origin. These results provide the first detailed characterization of the human adipocyte proteome, suggest an important role of adipocyte mitochondria, and demonstrate feasibility of this approach to examine alterations of adipocyte protein abundances in human diseases.
C1 [Xie, Xitao; Yi, Zhengping; Bowen, Benjamin; Wolf, Cassandra; Flynn, Charles R.; Sinha, Sandeep; Mandarino, Lawrence J.; Meyer, Christian] Arizona State Univ, Ctr Metab Biol, Tempe, AZ 85287 USA.
C3 Arizona State University; Arizona State University-Tempe
RP Meyer, C (corresponding author), Arizona State Univ, Ctr Metab Biol, Tempe, AZ 85287 USA.
EM christian.meyer@asu.edu
RI Meyer, Christian/G-2440-2013; Flynn, Charles/M-3895-2015
OI Flynn, Charles/0000-0002-3749-0598
FU NIH [R01DK47936, R01DK66483, R01DK081750, R21DK082820]; American
   Diabetes Association [1-09-CR-39]
FX We thank Dr. Corey and his team for the provision of adipose tissue
   samples. This study was supported in part by NIH grants R01DK47936
   (L.M.), R01DK66483 (L.M.), R01DK081750 (Z.P.Y.), and R21DK082820 (CM.)
   and the Clinical Research Grant 1-09-CR-39 from the American Diabetes
   Association (CM.).
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U1 0
U2 17
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1535-3893
EI 1535-3907
J9 J PROTEOME RES
JI J. Proteome Res.
PD SEP
PY 2010
VL 9
IS 9
BP 4521
EP 4534
DI 10.1021/pr100268f
PG 14
WC Biochemical Research Methods
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 645HS
UT WOS:000281443700019
PM 20812759
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Orfanidou, M
   Polyzos, SA
AF Orfanidou, Myrsini
   Polyzos, Stergios A.
TI Retinopathy in Metabolic Dysfunction-Associated Steatotic Liver Disease
SO MEDICINA-LITHUANIA
LA English
DT Review
DE hepatic fibrosis; metabolic dysfunction-associated steatotic liver
   disease; metabolic dysfunction-associated steatohepatitis; nonalcoholic
   fatty liver disease; nonalcoholic steatohepatitis; ocular disease;
   retinopathy
ID TYPE-2 DIABETIC-PATIENTS; INCREASED PREVALENCE; ADULT PATIENTS;
   GROWTH-FACTOR; FATTY; PATHOGENESIS; OBESITY; COMPLICATIONS;
   EPIDEMIOLOGY; ADROPIN
AB Metabolic dysfunction-associated steatotic liver disease (MASLD) is a multisystemic disease, i.e., influencing various organ systems beyond the liver and, thus, contributing to comorbidities. Characterized by excessive fat accumulation in the hepatocytes, MASLD is frequently linked to metabolic syndrome components, such as obesity, insulin resistance, dyslipidemia, and hypertension. Therefore, exploring the intricate connection between MASLD and other organ systems, including the eyes, seems to be essential. In this context, retinopathy has been investigated for its potential association with MASLD, since both conditions share common pathogenetic pathways. Chronic low-grade inflammation, oxidative stress, insulin resistance, and endothelial dysfunction are only some of those mechanisms contributing to disease progression and, possibly, determining the bidirectional interplay between the liver and retinal pathology. This narrative review aims to summarize data concerning the multisystemicity of MASLD, primarily focusing on its potential association with the eyes and, particularly, retinopathy. Identifying this possible association may emphasize the need for early screening and integrated management approaches that address the liver and eyes as interconnected components within the framework of a systemic disease. Further research is necessary to delineate the precise mechanisms and develop targeted interventions to mitigate the bidirectional impact between the liver and eyes, aiming to reduce the overall burden of disease and improve patient outcomes.
C1 [Orfanidou, Myrsini; Polyzos, Stergios A.] Aristotle Univ Thessaloniki, Sch Med, Lab Pharmacol 1, Thessaloniki 54124, Greece.
   [Orfanidou, Myrsini] Aristotle Univ Thessaloniki, Dept Ophthalmol 1, AHEPA Univ Hosp, Thessaloniki 54636, Greece.
C3 Aristotle University of Thessaloniki; Aristotle University of
   Thessaloniki; Ahepa University Hospital
RP Orfanidou, M; Polyzos, SA (corresponding author), Aristotle Univ Thessaloniki, Sch Med, Lab Pharmacol 1, Thessaloniki 54124, Greece.; Orfanidou, M (corresponding author), Aristotle Univ Thessaloniki, Dept Ophthalmol 1, AHEPA Univ Hosp, Thessaloniki 54636, Greece.
EM myrsinio@auth.gr; spolyzos@auth.gr
RI Polyzos, Stergios/H-2844-2019
OI Orfanidou, Myrsini/0000-0002-1379-9195
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NR 141
TC 2
Z9 2
U1 3
U2 3
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
SN 1010-660X
EI 1648-9144
J9 MEDICINA-LITHUANIA
JI Med. Lith.
PD JAN
PY 2025
VL 61
IS 1
AR 38
DI 10.3390/medicina61010038
PG 22
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA T3Z4L
UT WOS:001404427200001
PM 39859020
OA gold
DA 2025-06-11
ER

PT J
AU Liu, Y
   Wang, L
   Bao, EH
   Wang, JH
   Yang, L
   Wang, L
   Xia, L
   Wang, B
   Zhu, PY
AF Liu, Ying
   Wang, Li
   Bao, Er-Hao
   Wang, Jia-Hao
   Yang, Lin
   Wang, Lei
   Xia, Long
   Wang, Ben
   Zhu, Ping-Yu
TI Link Between Obstructive Sleep Apnea and Kidney Stones: NHANES 2015-2018
   and Mendelian Randomization
SO NATURE AND SCIENCE OF SLEEP
LA English
DT Article
DE obstructive sleep apnea; kidney stones; national health and nutrition
   examination survey; Mendelian randomization
ID FACTOR-KAPPA-B; OXIDATIVE STRESS; INTERMITTENT HYPOXIA; METABOLIC
   SYNDROME; INSULIN-RESISTANCE; DYSFUNCTION; PREVALENCE; CALCIUM; RISK
AB Purpose: The prevalence of Obstructive Sleep Apnea (OSA) is high, and there are many complications. Few studies have reported the relationship between OSA and kidney stones. The purpose of this study is to explore whether people at risk of OSA will increase the risk of kidney stones. Methods: This was a cross-sectional study, and information was collected through the National Health and Nutrition Examination Survey conducted from 2015 to 2018. Multiple logistic regression analyses were employed to calculate the odds ratios (ORs) and their 95% confidence intervals (CIs) for the link between obstructive sleep apnea and the presence of kidney stones. Additionally, to assess causality and reduce observational biases, five distinct two-sample Mendelian randomization techniques were applied. Results: Following the adjustment for relevant confounders, findings indicated a statistically significant correlation between obstructive sleep apnea (OSA) and higher prevalence of kidney stones (OR = 1.29; 95% CI: 1.00-1.66). Additionally, using the inverse-variance weighted approach in Mendelian randomization, results suggested a genetic predisposition to OSA might be causally linked to an elevated risk of developing kidney stones (OR: 1.00221, 95% CI 1.00056-1.00387). Conclusion: OSA promotes the formation of kidney stones, and the treatment and management of OSA can improve or mitigate the occurrence of kidney stones.
C1 [Liu, Ying; Bao, Er-Hao; Wang, Jia-Hao; Yang, Lin; Wang, Lei; Xia, Long; Wang, Ben; Zhu, Ping-Yu] North Sichuan Med Coll, Affiliated Hosp, Dept Urol, Nanchong, Sichuan, Peoples R China.
   [Wang, Li] Lanzhou Univ, Hosp 2, Dept Urol, Lanzhou, Peoples R China.
C3 North Sichuan Medical University; Lanzhou University
RP Zhu, PY (corresponding author), North Sichuan Med Coll, Affiliated Hosp, Dept Urol, Nanchong, Sichuan, Peoples R China.
EM zhupingyu@nsmc.edu.cn
RI Zhang, Zengqiang/J-3167-2014; Wang, Ben/MZR-4606-2025
FX Ying Liu, Li Wang, and Er-Hao Bao are co-first authors for this study.
   We express our gratitude to all individuals who contributed to and
   participated in the National Health and Nutrition Examination Survey, as
   well as to the researchers involved in the IEU open GWAS project and
   FinnGen database for providing genome-wide association studies data.
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NR 35
TC 2
Z9 2
U1 0
U2 4
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1179-1608
J9 NAT SCI SLEEP
JI NAT. SCI. SLEEP
PY 2024
VL 16
DI 10.2147/NSS.S483343
PG 12
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA I5A4G
UT WOS:001330377600001
PM 39376546
OA gold
DA 2025-06-11
ER

PT J
AU Qu, MY
   Zhou, X
   Wang, XT
   Li, HG
AF Qu, Mengyuan
   Zhou, Xuan
   Wang, Xiaotong
   Li, Honggang
TI Lipid-induced S-palmitoylation as a Vital Regulator of Cell Signaling
   and Disease Development
SO INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
LA English
DT Review
DE Palmitoylation; Lipid metabolism; Cancer; Inflammation;
   Neurodegeneration
ID FATTY-ACID SYNTHASE; PROTEIN PALMITOYLATION; ALZHEIMERS-DISEASE; ER
   STRESS; INHIBITION; CANCER; COA; CD36; REPLICATION; ACTIVATION
AB Lipid metabolites are emerging as pivotal regulators of protein function and cell signaling. The availability of intracellular fatty acid is tightly regulated by glycolipid metabolism and may affect human body through many biological mechanisms. Recent studies have demonstrated palmitate, either from exogenous fatty acid uptake or de novo fatty acid synthesis, may serve as the substrate for protein palmitoylation and regulate protein function via palmitoylation. Palmitoylation, the most-studied protein lipidation, encompasses the reversible covalent attachment of palmitate moieties to protein cysteine residues. It controls various cellular physiological processes and alters protein stability, conformation, localization, membrane association and interaction with other effectors. Dysregulation of palmitoylation has been implicated in a plethora of diseases, such as metabolic syndrome, cancers, neurological disorders and infections. Accordingly, it could be one of the molecular mechanisms underlying the impact of palmitate metabolite on cellular homeostasis and human diseases. Herein, we explore the relationship between lipid metabolites and the regulation of protein function through palmitoylation. We review the current progress made on the putative role of palmitate in altering the palmitoylation of key proteins and thus contributing to the pathogenesis of various diseases, among which we focus on metabolic disorders, cancers, inflammation and infections, neurodegenerative diseases. We also highlight the opportunities and new therapeutics to target palmitoylation in disease development.
C1 [Qu, Mengyuan; Wang, Xiaotong; Li, Honggang] Huazhong Univ Sci & Technol, Tongji Med Coll, Ctr Reprod Med, Inst Reprod Hlth, Wuhan, Peoples R China.
   [Zhou, Xuan] Shenzhen Third Peoples Hosp, Natl Clin Res Ctr Infect Dis, Shenzhen, Peoples R China.
   [Zhou, Xuan] Shenzhen Third Peoples Hosp, Dept Liver Dis, Shenzhen, Peoples R China.
   [Li, Honggang] Wuhan Tongji Reprod Med Hosp, Wuhan, Peoples R China.
C3 Huazhong University of Science & Technology; The Third People's Hospital
   of Shenzhen; The Third People's Hospital of Shenzhen
RP Li, HG (corresponding author), Huazhong Univ Sci & Technol, Tongji Med Coll, Inst Reprod Hlth, 13 Hangkong Rd, Wuhan 430030, Hubei, Peoples R China.
EM lhgyx@hotmail.com
RI li, honggang/AAY-1108-2020; Wang, Xiaotong/HRC-8244-2023
FU Training Program of the Major Research Plan of National Natural Science
   Foundation [91649111]; Fundamental Research Funds for the Central
   Universities [HUST: 2021JYCXJJ066]
FX This work was supported by Training Program of the Major Research Plan
   of National Natural Science Foundation NO. 91649111 and the Fundamental
   Research Funds for the Central Universities, HUST: 2021JYCXJJ066.
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NR 159
TC 49
Z9 54
U1 3
U2 34
PU IVYSPRING INT PUBL
PI LAKE HAVEN
PA PO BOX 4546, LAKE HAVEN, NSW 2263, AUSTRALIA
SN 1449-2288
J9 INT J BIOL SCI
JI Int. J. Biol. Sci.
PY 2021
VL 17
IS 15
BP 4223
EP 4237
DI 10.7150/ijbs.64046
PG 15
WC Biochemistry & Molecular Biology; Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics
GA WN5CJ
UT WOS:000711785200011
PM 34803494
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Soltaninejad, M
   Khammar, A
   Aminizadeh, M
   NabiAmjad, R
   Raei, M
   Hami, M
   Poursadeqiyan, M
AF Soltaninejad, Mohammadreza
   Khammar, Alireza
   Aminizadeh, Mohsen
   NabiAmjad, Reza
   Raei, Mehdi
   Hami, Mahsa
   Poursadeqiyan, Mohsen
TI Shift working disorders among nurses of Tehran hospital and its related
   factors in 2016
SO WORK-A JOURNAL OF PREVENTION ASSESSMENT & REHABILITATION
LA English
DT Article
DE Psychological disorders; digestive problems health problems; sleep
   disorder; night work
ID METABOLIC SYNDROME; JOB STRAIN; HEALTH; STRESS; NIGHT; LIFE; SLEEP;
   CONSEQUENCES; SYMPTOMS; WORKERS
AB INTRODUCTION: Many adverse effects occur among the nurses due to shift work Hence, the present study aimed to determine the prevalence of shift work-related disorders and its related factor among the nurses at Tehran University Subsidiary Hospital, Iran, and to find solutions for managing the relevant health problems.
   METHODS: In this cross-sectional study, the Survey of Shift workers (SOS) questionnaire and the Personal Information Form were used to collect data related to demographics and working conditions of 1259 randomly selected nurses working at Tehran University Subsidiary Hospital as statistical population.
   RESULTS: According to the results, psychological disorders (95%), digestive problems (85%) and social problems (80%) were the most frequent problems among the subjects. Additionally, the satisfaction rate was higher among the volunteer nurses compared to nurses who were forced to do shift work (P < 0.05).
   CONCLUSION: The nurses volunteered for shift work had higher satisfaction rate compared to nurses forced to shift work system; moreover, they had more job satisfaction and less shift work-related complaints. Therefore, it is important to select the nurses who are volunteer for shift work system. In addition, the shift work schedule in hospitals should be set based on workload and requirements because the shift schedule can adversely influence the social and family issues of the nurses, as well as their sleep quality and body biological process.
C1 [Soltaninejad, Mohammadreza] Univ Tehran Med Sci, Roozbeh Hosp, Dept Clin Psychol, Tehran, Iran.
   [Soltaninejad, Mohammadreza] Univ Tehran Med Sci, Roozbeh Hosp, Dept Psychiat, Tehran, Iran.
   [Soltaninejad, Mohammadreza] Iran Univ Med Sci, Rajaie Cardiovasc Med & Res Ctr, Tehran, Iran.
   [Khammar, Alireza] Zabol Univ Med Sci, Sch Hlth, Dept Occupat Hlth Engn, Zabol, Iran.
   [Aminizadeh, Mohsen] Kerman Univ Med Sci, Hlth Emergency & Disaster Res Ctr, Kerman, Iran.
   [Aminizadeh, Mohsen; Poursadeqiyan, Mohsen] Univ Social Welf & Rehabil Sci, Hlth Emergency & Disaster Res Ctr, Tehran, Iran.
   [NabiAmjad, Reza] Alborz Univ Med Sci, Noncommunicable Dis Res Ctr, Karaj, Iran.
   [Raei, Mehdi] Baqiyatallah Univ Med Sci, Life Style Inst, Hlth Res Ctr, Tehran, Iran.
   [Hami, Mahsa] Iran Univ Med Sci, Hlth Management & Econ Res Ctr, Tehran, Iran.
   [Poursadeqiyan, Mohsen] Torbat Heydariyeh Univ Med Sci, Dept Occupat Hlth Engn, Torbat Heydariyeh, Iran.
   [Poursadeqiyan, Mohsen] Torbat Heydariyeh Univ Med Sci, Hlth Sci Res Ctr, Torbat Heydariyeh, Iran.
C3 Tehran University of Medical Sciences; Roozbeh Hospital; Tehran
   University of Medical Sciences; Roozbeh Hospital; Iran University of
   Medical Sciences; Kerman University of Medical Sciences; Alborz
   University of Medical Sciences; Baqiyatallah University of Medical
   Sciences (BMSU); Iran University of Medical Sciences
RP Khammar, A (corresponding author), Zabol Univ Med Sci, Sch Hlth, Dept Occupat Hlth Engn, Zabol, Iran.; Poursadeqiyan, M (corresponding author), Torbat Heydariyeh Univ Med Sci, Hlth Sci Res Ctr, Dept Occupat Hlth Engn, Torbat Heydariyeh, Iran.
EM alireza.khammar@zbum.ac.ir; mo.poursadeghiyan@uswr.ac.ir
RI Poursadeghiyan, Mohsen/P-7883-2016; aminizadeh, mohsen/AAJ-9215-2021;
   Soltaninejad, Mohammadreza/AAA-2261-2019; Khammar, Alireza/V-8546-2017;
   Raei, Mehdi/S-2232-2017
OI Khammar, Alireza/0000-0001-9910-2485; Soltaninejad,
   Mohammadreza/0009-0006-5789-350X; Raei, Mehdi/0000-0002-5899-4744
FU  [:1503]
FX The authors would like to thank the authorities and personnel of Tehran
   University of Medical Sciences for their valuable cooperation and
   supporting this study. This article is part of project no:1503 in
   University of SocialWelfare and Rehabilitation Sciences, thanks for this
   university financial support.
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NR 57
TC 11
Z9 11
U1 1
U2 10
PU IOS PRESS
PI AMSTERDAM
PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS
SN 1051-9815
EI 1875-9270
J9 WORK
JI Work
PY 2020
VL 66
IS 1
BP 213
EP 219
DI 10.3233/WOR-203165
PG 7
WC Public, Environmental & Occupational Health
WE Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA NI2PO
UT WOS:000565197700022
PM 32417828
DA 2025-06-11
ER

PT J
AU Alam, P
   Raka, MA
   Khan, S
   Sarker, J
   Ahmed, N
   Nath, PD
   Hasan, N
   Mohib, MM
   Tisha, A
   Sagor, MA
AF Alam, Parisha
   Raka, Marzeea Ahmad
   Khan, Salma
   Sarker, Juthika
   Ahmed, Nowshin
   Nath, Pulak Dev
   Hasan, Nahid
   Mohib, Md Mohabbulla
   Tisha, Abida
   Sagor, Md Abu Taher
TI A clinical review of the effectiveness of tomato (Solanum
   lycopersicum) against cardiovascular dysfunction and related
   metabolic syndrome
SO JOURNAL OF HERBAL MEDICINE
LA English
DT Review
DE Vascular diseases; Obesity; Inflammation; Lycopene; Tomato
ID VITAMIN-E SUPPLEMENTATION; ACTIVATED PROTEIN-KINASE;
   SMOOTH-MUSCLE-CELLS; NF-KAPPA-B; OXIDATIVE STRESS; JUICE CONSUMPTION;
   HIGH-FAT; MODERATELY OVERWEIGHT; DIABETES-MELLITUS; HIGH-CARBOHYDRATE
AB Evidence suggests that obesity can contribute to the development of certain complications such as insulin resistance, dyslipidemia, accumulation of visceral fats and cardiovascular dysfunctions. Excess fat also blocks small blood vessels and arteries by accumulating plaque, which increases vascular inflammation, atherosclerosis and risk of stroke and other cardiovascular disease. In 2010, the World Health Organization established several recommendations regarding the benefits of plant and plant-derived phyto-nutrients against several chronic diseases along with the crude molecules. Tomato (Solanum lycopersicum) is protective against several chronic diseases. This review evaluates the roles of tomato-derived phyto-nutrients on cardiovascular diseases, obesity and diabetes management, and prevention of vascular inflammation in human subjects through reviewing human clinical studies. The findings of this review identify a clear connection between tomato supplementation and positive effects on biochemical parameters in humans, such as blood glucose, HbA1c, harmful lipid profile, inflammatory markers and free radicals which are likely to result in a decreased risk of obesity, diabetes and cardiovascular events. However, most studies were in young healthy participants and rarely assessed the effects of tomato upon incidence of cardiovascular events such as myocardial infarction. In conclusion, consuming fresh tomato supplements may contribute to the prevention of obesity, diabetes and cardiovascular dysfunctions through positively affecting biochemical pathways associated with these conditions.
C1 [Alam, Parisha; Raka, Marzeea Ahmad; Khan, Salma; Sarker, Juthika; Ahmed, Nowshin; Nath, Pulak Dev; Hasan, Nahid; Mohib, Md Mohabbulla; Tisha, Abida; Sagor, Md Abu Taher] North South Univ, Dept Pharmaceut Sci, Dhaka 1229, Bangladesh.
   [Mohib, Md Mohabbulla] Univ Lisbon, Fac Pharm, Res Inst Med iMed ULisboa, Lisbon, Portugal.
C3 North South University (NSU); Universidade de Lisboa
RP Sagor, MA (corresponding author), North South Univ, Dept Pharmaceut Sci, Dhaka 1229, Bangladesh.
EM sagor2008nsu@gmail.com
RI Mohib, Mohammad Mohabbulla/MAH-1723-2025
OI Mohib, Mohammad Mohabbulla/0000-0002-7910-7147
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NR 105
TC 17
Z9 18
U1 0
U2 19
PU ELSEVIER GMBH
PI MUNICH
PA HACKERBRUCKE 6, 80335 MUNICH, GERMANY
SN 2210-8033
EI 2210-8041
J9 J HERB MED
JI J. Herb. Med.
PD JUN
PY 2019
VL 16
AR 100235
DI 10.1016/j.hermed.2018.09.006
PG 13
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA IV0IH
UT WOS:000483962300001
DA 2025-06-11
ER

PT J
AU Prussick, RB
   Miele, L
AF Prussick, R. B.
   Miele, L.
TI Nonalcoholic fatty liver disease in patients with psoriasis: a
   consequence of systemic inflammatory burden?
SO BRITISH JOURNAL OF DERMATOLOGY
LA English
DT Review
ID LIFE-STYLE MODIFICATION; INSULIN-RESISTANCE; VITAMIN-D; INCREASED
   PREVALENCE; METABOLIC SYNDROME; ADIPOSE-TISSUE; CONFERS SUSCEPTIBILITY;
   CARDIOVASCULAR-DISEASE; MEDICAL COMORBIDITY; OXIDATIVE STRESS
AB Patients with psoriasis are at an increased risk for nonalcoholic fatty liver disease (NAFLD) compared with the general population. However, the pathophysiology underlying this comorbidity and elucidation of effective treatment strategies are unclear. This review provides insights into the possible role of chronic, low-grade inflammation in the pathogenesis of NAFLD in patients with psoriasis. Both conditions are associated with increased levels of proinflammatory adipokines (such as tumour necrosis factor-a and interleukin-6) and hepatokines, and decreased levels of adiponectin, an anti-inflammatory adipokine. This imbalance in inflammatory mediators could result in insulin resistance and, thereby, facilitate the occurrence and progression of NAFLD in a multistep manner. All patients with psoriasis should, therefore, be considered candidates for NAFLD screening and managed accordingly. Given the common aetiology of inflammation between these conditions, it is hypothesized that biological therapies for psoriasis may attenuate the systemic inflammatory process and progression of NAFLD in patients with psoriasis.
   What's already known about this topic?
   Patients with psoriasis have an increased risk of nonalcoholic fatty liver disease and increased levels of proinflammatory adipokines and hepatokines.
   What does this study add?
   This article explores the possible role of chronic, low-grade inflammation in the pathogenesis of nonalcoholic fatty liver disease.
   All patients with psoriasis should be screened for nonalcoholic fatty liver disease.
C1 [Prussick, R. B.] Washington Dermatol Ctr, Rockville, MD 20852 USA.
   [Prussick, R. B.] George Washington Univ, Dept Dermatol, Washington, DC 20052 USA.
   [Miele, L.] Catholic Univ Sacred Heart Rome, Inst Internal Med, Rome, Italy.
   [Miele, L.] Fdn Policlin Univ A Gemelli, Gastroenterol & Endocrine Metab Sci Dept, Gastroenterol Area, Rome, Italy.
C3 George Washington University; Catholic University of the Sacred Heart;
   IRCCS Policlinico Gemelli; Catholic University of the Sacred Heart;
   IRCCS Policlinico Gemelli
RP Prussick, RB (corresponding author), Washington Dermatol Ctr, Rockville, MD 20852 USA.; Prussick, RB (corresponding author), George Washington Univ, Dept Dermatol, Washington, DC 20052 USA.
EM drprussick@aol.com
RI Miele, Luca/C-2255-2015
OI Miele, Luca/0000-0003-3464-0068
FU Novartis Pharmaceuticals Corporation
FX Technical assistance with editing and styling of the manuscript for
   submission was provided by Oxford PharmaGenesis Inc. and was funded by
   Novartis Pharmaceuticals Corporation. The authors were fully responsible
   for all content and editorial decisions and received no financial
   support or other form of compensation related to the development of this
   manuscript.
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NR 108
TC 60
Z9 60
U1 0
U2 6
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0007-0963
EI 1365-2133
J9 BRIT J DERMATOL
JI Br. J. Dermatol.
PD JUL
PY 2018
VL 179
IS 1
BP 16
EP 29
DI 10.1111/bjd.16239
PG 14
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA GN8XP
UT WOS:000439461600140
PM 29235656
OA hybrid
DA 2025-06-11
ER

PT J
AU Al Sharif, M
   Alov, P
   Diukendjieva, A
   Vitcheva, V
   Simeonova, R
   Krasteva, I
   Shkondrov, A
   Tsakovska, I
   Pajeva, I
AF Al Sharif, Merilin
   Alov, Petko
   Diukendjieva, Antonia
   Vitcheva, Vessela
   Simeonova, Rumyana
   Krasteva, Ilina
   Shkondrov, Aleksandar
   Tsakovska, Ivanka
   Pajeva, Ilza
TI Molecular determinants of PPARγ partial agonism and related in
   silico/in vivo studies of natural saponins as potential type
   2 diabetes modulators
SO FOOD AND CHEMICAL TOXICOLOGY
LA English
DT Article
DE Type 2 diabetes; Saponins; PPAR gamma; Partial agonists; Pharmacophore;
   Docking
ID ACTIVATED RECEPTOR-GAMMA; OXIDATIVE STRESS; ASTRAGALUS-CORNICULATUS;
   ANTIOXIDANT ACTIVITY; LIPID-PEROXIDATION; NUCLEAR RECEPTORS;
   UP-REGULATION; PHARMACOPHORE; STREPTOZOTOCIN; DISCOVERY
AB The metabolic syndrome, which includes hypertension, type 2 diabetes (T2D) and obesity, has reached an epidemic-like scale. Saponins and sapogenins are considered as valuable natural products for ameliorating this pathology, possibly through the nuclear receptor PPAR gamma activation. The aims of this study were: to look for in vivo antidiabetic effects of a purified saponins' mixture (PSM) from Astragalus corniculatus Bieb; to reveal by in silico methods the molecular determinants of PPAR gamma partial agonism, and to investigate the potential PPAR gamma participation in the PSM effects. In the in vivo experiments spontaneously hypertensive rats (SHRs) with induced T2D were treated with PSM or pioglitazone as a referent PPAR gamma full agonist, and pathology-relevant biochemical markers were analysed. The results provided details on the PSM modulation of the glucose homeostasis and its potential mechanism. The in silico studies focused on analysis of the protein-ligand interactions in crystal structures of human PPAR gamma-partial agonist complexes, pharmacophore modelling and molecular docking. They outlined key pharmacophoric features, typical for the PPAR gamma partial agonists, which were used for pharmacophore-based docking of the main PSM sapogenin. The in silico studies, strongly suggest possible involvement of PPAR gamma-mediated mechanisms in the in vivo antidiabetic and antioxidant effects of PSM from A. corniculatus.
C1 [Al Sharif, Merilin; Alov, Petko; Diukendjieva, Antonia; Tsakovska, Ivanka; Pajeva, Ilza] Bulgarian Acad Sci, Inst Biophys & Biomed Engn, Acad G Bonchev Str,Bl 105, Sofia 1113, Bulgaria.
   [Vitcheva, Vessela; Simeonova, Rumyana; Krasteva, Ilina; Shkondrov, Aleksandar] Med Univ Sofia, Fac Pharm, Dunay 2 Str, Sofia 1000, Bulgaria.
C3 Bulgarian Academy of Sciences; Medical University Sofia
RP Al Sharif, M (corresponding author), Bulgarian Acad Sci, Inst Biophys & Biomed Engn, Acad G Bonchev Str,Bl 105, Sofia 1113, Bulgaria.
EM merilin.al@biomed.bas.bg; petko@biophys.bas.bg;
   antonia.diukendjieva@biomed.bas.bg; vesselavitcheva@yahoo.com;
   rvitanska@gmail.com; krasteva.ilina@abv.bg; a_shkondrov@abv.bg;
   ITsakovska@biomed.bas.bg; pajeva@biomed.bas.bg
RI Pajeva, Ilza/J-3242-2012; Diukendjieva, Antonia/JCF-1610-2023;
   Tsakovska, Ivanka/AAL-8256-2021; Krasteva, Ilina/AFI-7757-2022;
   Shkondrov, Aleksandar/AER-5726-2022; Simeonova, Rumyana/G-8002-2019
OI Alov, Petko/0000-0003-1320-2173; Shkondrov,
   Aleksandar/0000-0001-5091-6058; Diukendjieva,
   Antonia/0000-0003-3159-9872; Simeonova, Rumyana/0000-0003-4860-9053;
   Tsakovska, Ivanka/0000-0003-1389-1685; Krasteva,
   Ilina/0000-0001-8559-0369
FU National Science Fund of Bulgaria [DM 01/1/2016]; National Science Fund
   of Bulgaria [DM 01/1/2016]
FX The financial support from the National Science Fund of Bulgaria is
   acknowledged (grant DM 01/1/2016).
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NR 101
TC 11
Z9 12
U1 0
U2 21
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0278-6915
EI 1873-6351
J9 FOOD CHEM TOXICOL
JI Food Chem. Toxicol.
PD FEB
PY 2018
VL 112
BP 47
EP 59
DI 10.1016/j.fct.2017.12.009
PG 13
WC Food Science & Technology; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Toxicology
GA FW8GN
UT WOS:000425568900006
PM 29247773
DA 2025-06-11
ER

PT J
AU Zaulet, M
   Kevorkian, SEM
   Dinescu, S
   Cotoraci, C
   Suciu, M
   Herman, H
   Buburuzan, L
   Badulescu, L
   Ardelean, A
   Hermenean, A
AF Zaulet, Mihaela
   Kevorkian, Steliana Elvira Maria
   Dinescu, Sorina
   Cotoraci, Coralia
   Suciu, Maria
   Herman, Hildegard
   Buburuzan, Laura
   Badulescu, Liliana
   Ardelean, Aurel
   Hermenean, Anca
TI Protective effects of silymarin against bisphenol A-induced
   hepatotoxicity in mouse liver
SO EXPERIMENTAL AND THERAPEUTIC MEDICINE
LA English
DT Article
DE pro-inflammatory cytokines; silymarin; bisphenol A; hepatotoxicity;
   hepatoprotection
ID INDUCED HEPATIC DAMAGE; MOLECULAR-MECHANISMS; CARBON-TETRACHLORIDE;
   ENDOCRINE DISRUPTOR; OXIDATIVE STRESS; MILK THISTLE; INFLAMMATION;
   EXPOSURE; CELLS; ANTIOXIDANT
AB Bisphenol A (BPA) is an endocrine-disrupting chemical released into the environment, with severe consequences for human health, including metabolic syndrome and associated pathological conditions. Due to limited information on BPA-induced hepatotoxicity, the present study focused on investigating the association between BPA-induced toxicity and inflammatory markers in the liver, and how these injuries may be alleviated using the natural agent silymarin, a flavonoid with antioxidant properties obtained from Silybum marianum. Administration of BPA to male CD-1 mice for 10 days caused a significant increase in the number of cells immunopositive for interleukin 6 and tumor necrosis factor-alpha, pro-inflammatory cytokines that mediate the hepatic inflammatory response. Treatment with 200 mg/kg of silymarin concurrently with BPA for 10 days resulted in a diminished level of pro-inflammatory cytokines and in significantly reduced ultrastructural injuries. Additionally, silymarin was able to restore the significantly decreased glycogen deposits observed following BPA exposure to normal levels, thus favoring hepatic glycogenesis. This study represents the first report of silymarin ability to reduce hepatic lesions and to counteract inflammation caused by BPA in mice. A dose of 200 mg/kg silymarin was sufficient to induce a protective effect against structural and ultra-structural injuries induced by BPA and to lower the levels of pro-inflammatory cytokines observed in murine liver tissue following exposure to BPA.
C1 [Zaulet, Mihaela; Dinescu, Sorina] Univ Bucharest, Dept Biochem & Mol Biol, Bucharest 050095, Romania.
   [Kevorkian, Steliana Elvira Maria; Suciu, Maria; Herman, Hildegard; Hermenean, Anca] Vasile Goldis Western Univ Arad, Inst Life Sci, Dept Expt & Appl Biol, Arad 310414, Romania.
   [Cotoraci, Coralia] Vasile Goldis Western Univ Arad, Fac Med Pharm & Dent, Dept Hematol, Arad 310414, Romania.
   [Buburuzan, Laura; Ardelean, Aurel] Vasile Goldis Western Univ Arad, Fac Med, Dept Cell Biol, Arad 310414, Romania.
   [Badulescu, Liliana] Univ Agron Sci & Vet Med, Dept Bioengn Hortiviticultural Syst, Bucharest 011464, Romania.
   [Hermenean, Anca] Vasile Goldis Western Univ Arad, Fac Med, Dept Histol, 86 Rebreanu St, Arad 310414, Romania.
C3 University of Bucharest; Vasile Goldis Western University of Arad;
   Vasile Goldis Western University of Arad; Vasile Goldis Western
   University of Arad; University of Agronomic Science & Veterinary
   Medicine - Bucharest; Vasile Goldis Western University of Arad
RP Hermenean, A (corresponding author), Vasile Goldis Western Univ Arad, Fac Med, Dept Histol, 86 Rebreanu St, Arad 310414, Romania.
EM anca.hermenean@gmail.com
RI Hermenean, Anca/G-5360-2010; Suciu, Maria/IUQ-2285-2023; Herman,
   Hildegard/H-8449-2016; Dinescu, Sorina/H-1410-2016; Suciu,
   Maria/N-7405-2017; Badulescu, Liliana Aurelia/K-3400-2019
OI Dinescu, Sorina/0000-0001-7196-1712; Suciu, Maria/0000-0001-5449-9108;
   Badulescu, Liliana Aurelia/0000-0003-1819-5128; Herman,
   Hildegard/0000-0002-6741-0245; Hermenean, Anca/0000-0001-8510-6653
FU Project 'Doctoral and Post-doctoral programs [POSDRU/159/1.5/S/133391];
   Institute for Research of the University of Bucharest (ICUB)
   [BEST-NetWORK 16_PA07-C1]
FX This study was supported by a strategic grant (no.
   POSDRU/159/1.5/S/133391) Project 'Doctoral and Post-doctoral programs of
   excellence for highly qualified human resources training for research in
   the field of Life sciences, Environment and Earth Science' cofinanced by
   the European Social Fund within the Sectorial Operational Program Human
   Resources Development 2007-2013. This study was also financed by the
   Institute for Research of the University of Bucharest (ICUB), through
   'Scholarships for Excellence in Research for Young Researchers, 2015
   Competition' Project and START Project: BEST-NetWORK 16_PA07-C1.
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NR 55
TC 35
Z9 35
U1 0
U2 36
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1792-0981
EI 1792-1015
J9 EXP THER MED
JI Exp. Ther. Med.
PD MAR
PY 2017
VL 13
IS 3
BP 821
EP 828
DI 10.3892/etm.2017.4066
PG 8
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA EO9JJ
UT WOS:000397004700004
PM 28450905
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Remely, M
   Ferk, F
   Sterneder, S
   Setayesh, T
   Roth, S
   Kepcija, T
   Noorizadeh, R
   Rebhan, I
   Greunz, M
   Beckmann, J
   Wagner, KH
   Knasmüller, S
   Haslberger, AG
AF Remely, Marlene
   Ferk, Franziska
   Sterneder, Sonja
   Setayesh, Tahereh
   Roth, Sylvia
   Kepcija, Tatjana
   Noorizadeh, Rahil
   Rebhan, Irene
   Greunz, Martina
   Beckmann, Johanna
   Wagner, Karl-Heinz
   Knasmuller, Siegfried
   Haslberger, Alexander G.
TI EGCG Prevents High Fat Diet-Induced Changes in Gut Microbiota, Decreases
   of DNA Strand Breaks, and Changes in Expression and DNA Methylation of
   Dnmt1 and MLH1 in C57BL/6J Male Mice
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Article
ID GREEN TEA POLYPHENOL; COA-TRANSFERASE GENES; OXIDATIVE STRESS; COMET
   ASSAY; EPIGALLOCATECHIN GALLATE; METABOLIC SYNDROME;
   (-)-EPIGALLOCATECHIN GALLATE; DAMAGE; OBESITY; REPAIR
AB Obesity as a multifactorial disorder involves low-grade inflammation, increased reactive oxygen species incidence, gut microbiota aberrations, and epigenetic consequences. Thus, prevention and therapies with epigenetic active antioxidants, (-)-Epigallocatechin-3- gallate (EGCG), are of increasing interest. DNA damage, DNA methylation and gene expression of DNA methyltransferase 1, interleukin 6, and MutL homologue 1 were analyzed in C57BL/6J male mice fed a high-fat diet (HFD) or a control diet (CD) with and without EGCG supplementation. Gut microbiota was analyzed with quantitative real-time polymerase chain reaction. An induction of DNA damage was observed, as a consequence of HFD-feeding, whereas EGCG supplementation decreased DNA damage. HFD-feeding induced a higher inflammatory status. Supplementation reversed these effects, resulting in tissue specific gene expression and methylation patterns of DNA methyltransferase 1 and MutL homologue 1. HFD feeding caused a significant lower bacterial abundance. The Firmicutes/Bacteroidetes ratio is significantly lower in HFD + EGCG but higher in CD + EGCG compared to control groups. The results demonstrate the impact of EGCG on the one hand on gut microbiota which together with dietary components affects host health. On the other hand effects may derive from antioxidative activities as well as epigenetic modifications observed on CpG methylation but also likely to include other epigenetic elements.
C1 [Remely, Marlene; Sterneder, Sonja; Roth, Sylvia; Kepcija, Tatjana; Rebhan, Irene; Greunz, Martina; Beckmann, Johanna; Wagner, Karl-Heinz; Haslberger, Alexander G.] Univ Vienna, Dept Nutr Sci, Vienna, Austria.
   [Ferk, Franziska; Setayesh, Tahereh; Noorizadeh, Rahil; Knasmuller, Siegfried] Med Univ Vienna, Inst Canc Res, Dept Med 1, Vienna, Austria.
C3 University of Vienna; Medical University of Vienna
RP Haslberger, AG (corresponding author), Univ Vienna, Dept Nutr Sci, Vienna, Austria.
EM alexander.haslberger@univie.ac.at
RI Haslberger, Alexander/B-9120-2013; Setayesh, Tahereh/AAD-8111-2019;
   Wagner, Karl-Heinz/B-9098-2013; Knasmuller, Siegfried/P-4347-2014
OI Wagner, Karl-Heinz/0000-0002-1683-7265; Sterneder,
   Sonja/0000-0001-8740-630X; Knasmuller, Siegfried/0000-0002-1638-4438;
   Ferk, Franziska/0000-0001-6400-5386; Setayesh,
   Tahereh/0000-0002-1770-208X; Haslberger, Alexander/0000-0001-9699-537X
FU Austrian Science Fund (FWF) [AP2658721]; Austrian Science Fund (FWF)
   [P26587] Funding Source: Austrian Science Fund (FWF)
FX The work was funded by the Austrian Science Fund (FWF; AP2658721).
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NR 68
TC 78
Z9 87
U1 0
U2 51
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PY 2017
VL 2017
AR 3079148
DI 10.1155/2017/3079148
PG 17
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA EI6ER
UT WOS:000392588300001
PM 28133504
OA Green Submitted, Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Solak, B
   Dikicier, BS
   Cosansu, NC
   Erdem, T
AF Solak, Berna
   Dikicier, Bahar Sevimli
   Cosansu, Nur Cihan
   Erdem, Teoman
TI Neutrophil to lymphocyte ratio in patients with vitiligo
SO POSTEPY DERMATOLOGII I ALERGOLOGII
LA English
DT Article
DE neutrophil to lymphocyte ratio; vitiligo; inflammation
ID HOMOCYSTEINE; MELANIN
AB Introduction: There are a few studies showing an increased risk of insulin resistance, metabolic syndrome, and oxidative stress in patients with vitiligo.
   Aim: To investigate whether systemic inflammation is increased in vitiligo patients in a case-control study design.
   Material and methods: Nonsegmental vitiligo patients who had been followed at the outpatient dermatology clinic of a university-affiliated teaching hospital, and healthy controls were enrolled in the study. Patients who were receiving systemic treatments and having a systemic disease such as diabetes mellitus and thyroiditis were excluded. Demographic features were recorded and peripheral blood samples were taken from all participants to study serum whole blood count, creatinine, and C-reactive protein (CRP).
   Results: Fifty patients with localized vitiligo, 43 patients with generalized vitiligo, and 50 healthy volunteers were enrolled in the study. Neutrophil to lymphocyte ratio and serum CRP levels were significantly higher in patients who have generalized vitiligo than those with localized vitiligo and healthy controls. However, there was no significant difference regarding neutrophil to lymphocyte ratio (NLR) and CRP between localized vitiligo and control groups.
   Conclusions: Patients with generalized vitiligo seem to have increased systemic inflammation compared with localized vitiligo and control subjects in our cohort. To the best of our knowledge, this is the first study in the literature showing increased NLR values in generalized vitiligo patients. Further studies with cardiovascular disease markers are required to elicit this association better.
C1 [Solak, Berna; Cosansu, Nur Cihan; Erdem, Teoman] Sakarya Univ, Dept Dermatol, Fac Med, TR-54000 Sakarya, Turkey.
   [Dikicier, Bahar Sevimli] Sakarya Univ, Training & Res Hosp, Dept Dermatol, Sakarya, Turkey.
C3 Sakarya University; Sakarya Training & Research Hospital; Sakarya
   University
RP Solak, B (corresponding author), Sakarya Univ, Dept Dermatol, Fac Med, TR-54000 Sakarya, Turkey.
EM bernasolakmd@gmail.com
RI Cosansu, Kahraman/JLK-9187-2023; dikicier, bahar/C-4725-2019; Solak,
   Berna/AAD-1396-2020
CR Ala Y, 2015, AUTOIMMUN DIS, V2015, DOI 10.1155/2015/423490
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NR 17
TC 22
Z9 22
U1 0
U2 6
PU TERMEDIA PUBLISHING HOUSE LTD
PI POZNAN
PA KLEEBERGA ST 2, POZNAN, 61-615, POLAND
SN 1642-395X
J9 POSTEP DERM ALERGOL
JI Postep. Dermatol. Alergol.
PY 2017
VL 34
IS 5
BP 468
EP 470
DI 10.5114/ada.2017.71114
PG 3
WC Allergy; Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Allergy; Dermatology
GA FN8RE
UT WOS:000416292400011
PM 29515336
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Hebert-Schuster, M
   Cottart, CH
   Laguillier-Morizot, C
   Raynaud-Simon, A
   Golmard, JL
   Cynober, L
   Beaudeux, JL
   Fabre, EE
   Nivet-Antoine, V
AF Hebert-Schuster, M.
   Cottart, C. H.
   Laguillier-Morizot, C.
   Raynaud-Simon, A.
   Golmard, J. L.
   Cynober, L.
   Beaudeux, J. L.
   Fabre, E. E.
   Nivet-Antoine, V.
TI Catalase rs769214 SNP in elderly malnutrition and during renutrition: Is
   glucagon to blame?
SO FREE RADICAL BIOLOGY AND MEDICINE
LA English
DT Article
DE Polymorphism; Glucagon; Elderly; Catalase; Renutrition; Glucose; PAX6;
   Free radicals
ID OXIDATIVE STRESS; METABOLIC SYNDROME; GLUCOSE-TOLERANCE; ENTERAL
   NUTRITION; GENE; ALPHA; HAPLOTYPE; PAX6; TRANSCRIPTION; IMPACT
AB Impaired glucose tolerance is common during aging. The transcription factor PAX6 is involved in glucose homeostasis. Computational promoter sequence analysis of the catalase gene highlighted a putative PAX6 binding site on the rs769214 polymorphism A allele. Creation of this binding site has been suggested to explain renutrition inefficiency in malnourished elderly patients. Our aim was to evaluate the link between the rs769214 polymorphism of the catalase gene and glucose homeostasis in malnourished elderly patients at inclusion and during renutrition. Thirty-three malnourished elderly Caucasian inpatients were recruited. Nutritional and inflammatory statuses were assessed and a multiplex adipokine analysis was conducted at inclusion and discharge from the Geriatric Nutritional Care Unit at Charles-Foix Hospital (Ivry-sur-Seine, France). Serum glucagon, PAI-1. and TNF-alpha levels were significantly lower in the A-allele carriers at inclusion. During renutrition, A-allele carriers exhibited increased serum glucagon, PAI-1, and TNF-alpha variation. After renutrition, levels of these parameters were similar for A-allele carriers and G-allele carriers. A logistic ordinal multivariate regression analysis linked only variation of glucagon to rs769214 SNP. These results support a role for catalase SNP in the efficiency of renutrition in malnourished elderly patients via the modulation of glucagon secretion, probably involving PAX6. (C) 2011 Elsevier Inc. All rights reserved.
C1 [Hebert-Schuster, M.; Cottart, C. H.; Raynaud-Simon, A.; Cynober, L.; Beaudeux, J. L.; Nivet-Antoine, V.] Paris Descartes Univ, Fac Pharm, EA 4466, F-75006 Paris, France.
   [Hebert-Schuster, M.; Cynober, L.] Cochin Hosp, Interhosp Clin Chem Dept, AP HP, F-75014 Paris, France.
   [Hebert-Schuster, M.; Cynober, L.] Hop Hotel Dieu, Interhosp Clin Chem Dept, AP HP, F-75014 Paris, France.
   [Cottart, C. H.; Laguillier-Morizot, C.; Beaudeux, J. L.; Nivet-Antoine, V.] Charles Foix Hosp, Dept Clin Chem, AP HP, F-94205 Ivry, France.
   [Raynaud-Simon, A.] Hop Bichat Claude Bernard, Fac Med Denis Diderot, Dept Geriatr, AP HP, F-75877 Paris 18, France.
   [Golmard, J. L.] Hop La Pitie Salpetriere, Dept Biostat, AP HP, F-75651 Paris 13, France.
   [Golmard, J. L.] Univ Paris 06, F-75013 Paris, France.
   [Fabre, E. E.] Avicenne Hosp, Dept Clin Chem, AP HP, F-93009 Bobigny, France.
   [Fabre, E. E.] Univ Paris 13, INSERM, UFR SMBH, U978, F-93000 Bobigny, France.
C3 Universite Paris Cite; Assistance Publique Hopitaux Paris (APHP);
   Universite Paris Cite; Hopital Universitaire Cochin - APHP; Assistance
   Publique Hopitaux Paris (APHP); Universite Paris Cite; Hopital
   Universitaire Hotel-Dieu - APHP; Assistance Publique Hopitaux Paris
   (APHP); Hopital Universitaire Charles-Foix - APHP; Sorbonne Universite;
   Assistance Publique Hopitaux Paris (APHP); Universite Paris Cite;
   Hopital Universitaire Bichat-Claude Bernard - APHP; Assistance Publique
   Hopitaux Paris (APHP); Hopital Universitaire Pitie-Salpetriere - APHP;
   Sorbonne Universite; Sorbonne Universite; Assistance Publique Hopitaux
   Paris (APHP); Hopital Universitaire Avicenne - APHP; Universite Paris
   13; Institut National de la Sante et de la Recherche Medicale (Inserm)
RP Nivet-Antoine, V (corresponding author), Paris Descartes Univ, Fac Pharm, EA 4466, F-75006 Paris, France.
EM valerie.nivet-antoine@parisdescartes.fr
RI Cynober, Luc/ABB-2368-2020; Nivet-Antoine, Valerie/R-1981-2017
OI LAGUILLIER-MORIZOT, Christelle/0000-0002-2704-9774; Fabre,
   Emmanuelle/0000-0001-6614-2448; Hebert-Schuster,
   Marylise/0000-0002-8221-4023; Nivet-Antoine,
   Valerie/0000-0003-2490-0428; Cottart, Charles-Henry/0000-0003-3776-957X
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NR 31
TC 17
Z9 19
U1 0
U2 6
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0891-5849
EI 1873-4596
J9 FREE RADICAL BIO MED
JI Free Radic. Biol. Med.
PD OCT 15
PY 2011
VL 51
IS 8
BP 1583
EP 1588
DI 10.1016/j.freeradbiomed.2011.07.016
PG 6
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 824MS
UT WOS:000295206600013
PM 21827848
DA 2025-06-11
ER

PT J
AU Eguchi, Y
   Mizuta, T
   Ishibashi, E
   Kitajima, Y
   Oza, N
   Nakashita, S
   Hara, M
   Iwane, S
   Takahashi, H
   Akiyama, T
   Ario, K
   Kawaguchi, Y
   Yasutake, T
   Iwakiri, R
   Ozaki, I
   Hisatomi, A
   Eguchi, T
   Ono, N
   Fujimoto, K
AF Eguchi, Yuichiro
   Mizuta, Toshihiko
   Ishibashi, Eriko
   Kitajima, Yoichiro
   Oza, Noriko
   Nakashita, Shunya
   Hara, Megumi
   Iwane, Shinji
   Takahashi, Hirokazu
   Akiyama, Takumi
   Ario, Keisuke
   Kawaguchi, Yasunori
   Yasutake, Tsutomu
   Iwakiri, Ryuichi
   Ozaki, Iwata
   Hisatomi, Akitaka
   Eguchi, Takahisa
   Ono, Naofumi
   Fujimoto, Kazuma
TI Hepatitis C virus infection enhances insulin resistance induced by
   visceral fat accumulation
SO LIVER INTERNATIONAL
LA English
DT Article
DE abdominal obesity; adipocytokine; central obesity; metabolic syndrome;
   oxidative stress
ID NECROSIS FACTOR-ALPHA; BETA-CELL FUNCTION; DIABETES-MELLITUS; LIVER
   FIBROSIS; RECEPTOR SUBSTRATE-1; TNF-ALPHA; STEATOSIS; HCV; ASSOCIATION;
   ADIPONECTIN
AB To clarify the impact of visceral obesity on hepatitis C virus (HCV)-infected patients, we examined the relationship between insulin resistance development and visceral fat accumulation.
   We analyzed 87 HCV-infected patients with mild fibrosis (stage 1 or 2) in comparison with 125 sex- and age-matched patients with non-alcoholic fatty liver disease (NAFLD). The degree of visceral fat area (VFA; cm(2)) at the umbilical level was measured by abdominal computed tomography and divided into two grades: no visceral obesity, VFA < 100 and visceral obesity, VFA >= 100. Insulin resistance was evaluated by homeostasis model assessment of insulin resistance (HOMA-IR) and the quantitative insulin sensitivity check index (QUICKI). Pancreatic beta-cell function was evaluated by homeostasis model assessment of beta-cell function (HOMA-beta). Serum soluble tumour necrosis factor (TNF)-receptors 1 and 2 and adiponectin were measured.
   Insulin resistance evaluated by HOMA-IR and QUICKI was correlated with visceral fat accumulation, and was higher in HCV patients than in NAFLD patients with visceral obesity. HOMA-beta was higher in HCV patients than in NAFLD patients for each VFA grade. Serum-soluble TNF-receptors 1 and 2 were higher in HCV patients than in NAFLD patients with visceral obesity.
   Hepatitis C virus infection is a risk factor for development of insulin resistance, particularly in patients with visceral obesity.
C1 [Eguchi, Yuichiro; Mizuta, Toshihiko; Ishibashi, Eriko; Kitajima, Yoichiro; Oza, Noriko; Iwane, Shinji; Takahashi, Hirokazu; Akiyama, Takumi; Ario, Keisuke; Kawaguchi, Yasunori; Yasutake, Tsutomu; Iwakiri, Ryuichi; Ozaki, Iwata; Hisatomi, Akitaka; Fujimoto, Kazuma] Saga Med Sch, Dept Internal Med, Saga 8498501, Japan.
   [Ishibashi, Eriko; Kitajima, Yoichiro; Oza, Noriko; Nakashita, Shunya; Eguchi, Takahisa; Ono, Naofumi] Eguchi Hosp, Saga, Japan.
   [Hara, Megumi] Saga Med Sch, Dept Prevent Med, Saga 8498501, Japan.
C3 Saga University; Saga University
RP Eguchi, Y (corresponding author), Saga Med Sch, Dept Internal Med, 5-1-1 Nabeshima, Saga 8498501, Japan.
EM eguchiyu@cc.saga-u.ac.jp
OI Takahashi, Hirokazu/0000-0003-1900-4389; Hara,
   Megumi/0000-0002-8708-3237
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NR 50
TC 30
Z9 32
U1 0
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1478-3223
EI 1478-3231
J9 LIVER INT
JI Liver Int.
PD FEB
PY 2009
VL 29
IS 2
BP 213
EP 220
DI 10.1111/j.1478-3231.2008.01853.x
PG 8
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 392DW
UT WOS:000262284100014
PM 18710430
DA 2025-06-11
ER

PT J
AU Powell, EE
   Jonsson, JR
   Clouston, AD
AF Powell, EE
   Jonsson, JR
   Clouston, AD
TI Steatosis: Co-factor in other liver diseases
SO HEPATOLOGY
LA English
DT Review
ID CHRONIC HEPATITIS-C; NONALCOHOLIC FATTY LIVER; INDEPENDENT RISK-FACTOR;
   BODY-MASS INDEX; INSULIN-RESISTANCE; HEPATOCELLULAR-CARCINOMA;
   VIRUS-INFECTION; TRANSGENIC MICE; CORE PROTEIN; CRYPTOGENIC CIRRHOSIS
AB The prevalence of fatty liver is rising in association with the global increase in obesity and type 2 diabetes. In the past, simple steatosis was regarded as benign, but the presence of another liver disease may provide a synergistic combination of steatosis, cellular adaptation, and oxidative damage that aggravates liver injury. In this review, a major focus is on the role of steatosis as a co-factor in chronic hepatitis C (HCV), where the mechanisms promoting fibrosis and the effect of weight reduction in minimizing liver injury have been most widely studied. Steatosis, obesity, and associated metabolic factors may also modulate the response to alcohol- and drug-induced liver disease and may be risk factors for the development of hepatocellular cancer. The pathogenesis of injury in obesity-related fatty liver disease involves a number of pathways, which are currently under investigation. Enhanced oxidative stress, increased susceptibility to apoptosis, and a dysregulated response to cellular injury have been implicated, and other components of the metabolic syndrome such as hyperinsulinernia and hyperglycemia are likely to have a role. Fibrosis also may be increased as a by-product of altered hepatocyte regeneration and activation of bipotential hepatic progenitor cells. In conclusion, active management of obesity and a reduction in steatosis may improve liver injury and decrease the progression of fibrosis.
C1 Univ Queensland, Princess Alexandra Hosp, Sch Med, So Div, Brisbane, Qld 4102, Australia.
C3 Princess Alexandra Hospital; University of Queensland
RP Univ Queensland, Princess Alexandra Hosp, Sch Med, So Div, Ipswich Rd, Brisbane, Qld 4102, Australia.
EM Elizabeth_Powell@health.qld.gov.au
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OI Clouston, Andrew/0000-0002-9601-7952; Powell,
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NR 103
TC 307
Z9 322
U1 1
U2 16
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0270-9139
EI 1527-3350
J9 HEPATOLOGY
JI Hepatology
PD JUL
PY 2005
VL 42
IS 1
BP 5
EP 13
DI 10.1002/hep.20750
PG 9
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 941BI
UT WOS:000230189200001
PM 15962320
OA Bronze
DA 2025-06-11
ER

PT J
AU Sari, DR
   Ramadhan, RN
   Agustin, D
   Munir, M
   Izzatunnisa, N
   Susanto, J
   Halim, S
   Pranoto, A
   Rejeki, PS
AF Sari, Dewi Ratna
   Ramadhan, Roy Novri
   Agustin, Dini
   Munir, Misbakhul
   Izzatunnisa, Nabilah
   Susanto, Joni
   Halim, Shariff
   Pranoto, Adi
   Rejeki, Purwo Sri
TI The Effect of Exercise Intensity on Anthropometric Parameters and Renal
   Damage in High Fructose- Induced Mice
SO RETOS-NUEVAS TENDENCIAS EN EDUCACION FISICA DEPORTE Y RECREACION
LA English
DT Article
DE Exercise; healthy lifestyle; obesity; renal histology
ID INTERSTITIAL FIBROSIS; METABOLIC SYNDROME; OXIDATIVE STRESS; OBESITY;
   SYSTEM; DYSFUNCTION; MECHANISMS; ENDURANCE; MARKERS; INDEX
AB Excessive fructose intake disrupts carbohydrate and lipid metabolism in the kidney, resulting in kidney injury. Exercise has proven to improve the renal fatty acid metabolism, but the effect of various exercise intensities in preventing renal disorders is still unknown. The purpose of this study is to analyze the effect of various exercise intensities on anthropometric parameters and renal damage in high fructose-induced mice. The subjects were thirty-six male mice (20-30 g), aged 8 weeks were obtained and randomly assigned into 4 groups: HFr-Sed (sedentary), HFr-Ex(1) (low-intensity exercise), HFr-Ex(2) (moderate-intensity exercise), and HFr-Ex(3 )(high-intensity exercise). They were fed standard chow and high fructose solution (30%), per-oral, ad libitum for 8 weeks. The exercised groups underwent swimming, with 80% maximum duration/session, 3x/week, for 8 weeks. The result showed that there were significant differences in body weight (p < 0.001), body length (p = 0.001), Lee index (p = 0.020), Body Mass Index (BMI) (p = 0.004), and serum creatinine (SCr) level (p < 0.001). However, the glomerulosclerosis index and interstitial fibrosis degree were not significantly different in all groups. It can be concluded that various intensities of exercise affect the body composition and SCr level, especially moderate-intensity exercise, but do not impact the improvement of the histological kidney in high fructose-induced mice.
C1 [Sari, Dewi Ratna; Ramadhan, Roy Novri; Agustin, Dini; Munir, Misbakhul; Izzatunnisa, Nabilah; Susanto, Joni; Pranoto, Adi; Rejeki, Purwo Sri] Univ Airlangga, Surabaya, Indonesia.
   [Halim, Shariff] Univ Technol MARA UiTM Pulau Pinang, Permatang Pauh, Malaysia.
C3 Airlangga University
RP Rejeki, PS (corresponding author), Univ Airlangga, Surabaya, Indonesia.
EM purwo-s-r@fk.unair.ac.id
RI Mohamad Shariff, Mohamad Halim/IZD-8681-2023; Pranoto,
   Adi/JFS-8175-2023; Rejeki, Purwo/ADH-4728-2022
OI Sari, Dewi Ratna/0000-0001-5150-8902; Ramadhan, Roy
   Novri/0000-0001-6100-9015
FU Faculty of Medicine Universitas Airlangga, Indonesia
   [1303/UN3.1.1/PT/2022]
FX <BOLD> Financial Support </BOLD> This study received financial support
   from an internal research grant provided by the Faculty of Medicine
   Universitas Airlangga, Indonesia, grant number: 1303/UN3.1.1/PT/2022.
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NR 113
TC 6
Z9 6
U1 0
U2 1
PU FEDERACION ESPANOLA ASOC DOCENTES EDUCACION FISICA-FEADEF
PI MURCIA
PA C CABO VIDIO 27, SAN JAVIER, MURCIA, 30730, SPAIN
SN 1579-1726
EI 1988-2041
J9 RETOS-NUEV TEND EDUC
JI Retos
PY 2024
IS 51
BP 1194
EP 1209
PG 16
WC Hospitality, Leisure, Sport & Tourism
WE Emerging Sources Citation Index (ESCI)
SC Social Sciences - Other Topics
GA AA9I5
UT WOS:001115846500001
DA 2025-06-11
ER

PT J
AU Masaki, N
   Adachi, T
   Tomiyama, H
   Kohro, T
   Suzuki, T
   Ishizu, T
   Ueda, S
   Yamazaki, T
   Furumoto, T
   Kario, K
   Inoue, T
   Koba, S
   Takemoto, Y
   Hano, T
   Sata, M
   Ishibashi, Y
   Node, K
   Maemura, K
   Ohya, Y
   Furukawa, T
   Ito, H
   Higashi, Y
   Yamashina, A
   Takase, B
AF Masaki, Nobuyuki
   Adachi, Takeshi
   Tomiyama, Hirofumi
   Kohro, Takahide
   Suzuki, Toru
   Ishizu, Tomoko
   Ueda, Shinichiro
   Yamazaki, Tsutomu
   Furumoto, Tomoo
   Kario, Kazuomi
   Inoue, Teruo
   Koba, Shinji
   Takemoto, Yasuhiko
   Hano, Takuzo
   Sata, Masataka
   Ishibashi, Yutaka
   Node, Koichi
   Maemura, Koji
   Ohya, Yusuke
   Furukawa, Taiji
   Ito, Hiroshi
   Higashi, Yukihito
   Yamashina, Akira
   Takase, Bonpei
TI Reduced reactive hyperemia of the brachial artery in diabetic patients
   assessed by repeated measurements: The FMD-J B study
SO PHYSIOLOGICAL REPORTS
LA English
DT Article
DE clinical study; diabetes mellitus; endothelial function; hyperglycemia;
   reactive hyperemia
ID SENSITIVE POTASSIUM CHANNELS; FLOW-MEDIATED DILATION; ENDOTHELIAL
   FUNCTION; HUMAN FOREARM; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   SHEAR-STRESS; NITRIC-OXIDE; K+ CHANNELS; DYSFUNCTION
AB Type 2 diabetes mellitus (T2DM) is a major cause of microvascular dysfunction. However, its effect on blood flow patterns during ischemic demand has not been adequately elucidated. In this study, we investigated the hypothesis that microvascular dysfunction in patients with T2DM manifests as brachial reactive hyperemia (BRH), defined as the ratio of peak blood flow velocities in a brachial artery before and after forearm cuff occlusion. The study enrolled 943 subjects (men, n = 152 [T2DM] and n = 371 [non-T2DM]; women, n = 107 [T2DM] and n = 313 [non-T2DM], respectively) with no history of cardiovascular disease. Semiautomatic measurements were obtained three times at 1.5-year intervals to confirm the reproducibility of factors involved in BRH for each sex. An age-adjusted mixed model demonstrated attenuated BRH in the presence of T2DM in both men (p = 0.022) and women (p = 0.031) throughout the study period. Post hoc analysis showed that the estimated BRH was significantly attenuated in patients with T2DM regardless of sex, except at baseline in women. In multivariate regression analysis, T2DM was a negative predictor of BRH at every measurement in men. For women, BRH was more strongly associated with alcohol consumption. Repeated measurements analysis revealed that T2DM was associated with attenuated postocclusion reactive hyperemia.
C1 [Masaki, Nobuyuki; Takase, Bonpei] Natl Def Med Coll, Dept Intens Care Med, Tokorozawa, Japan.
   [Adachi, Takeshi] Natl Def Med Coll, Dept Cardiol, Tokorozawa, Japan.
   [Tomiyama, Hirofumi; Yamashina, Akira] Tokyo Med Univ, Dept Cardiol, Tokyo, Japan.
   [Kohro, Takahide] Jichi Med Univ, Dept Hosp Planning & Management, Med Informat, Sch Med, Shimotsuke, Tochigi, Japan.
   [Suzuki, Toru] Univ Leicester, Cardiovasc Med, Leicester, England.
   [Ishizu, Tomoko] Univ Tsukuba, Inst Clin Med, Cardiovasc Div, Tsukuba, Ibaraki, Japan.
   [Ueda, Shinichiro] Univ Ryukyus, Dept Clin Pharmacol & Therapeut, Sch Med, Nishihara, Okinawa, Japan.
   [Yamazaki, Tsutomu] Univ Tokyo, Fac Med, Dept Clin Epidemiol & Syst, Tokyo, Japan.
   [Furumoto, Tomoo] Hokkaido Univ, Dept Cardiovasc Med, Grad Sch Med, Sapporo, Japan.
   [Kario, Kazuomi] Jichi Med Univ, Div Cardiovasc Med, Sch Med, Shimotsuke, Tochigi, Japan.
   [Inoue, Teruo] Dokkyo Med Univ, Nasu Red Cross Hosp, Mibu, Tochigi, Japan.
   [Koba, Shinji] Showa Univ, Dept Med, Div Cardiol, Sch Med, Tokyo, Japan.
   [Takemoto, Yasuhiko] Osaka City Univ, Dept Internal Med & Cardiol, Grad Sch Med, Osaka, Japan.
   [Hano, Takuzo] Wakayama Med Univ, Postgrad Sch Med, Dept Med Educ & Populat based Med, Wakayama, Japan.
   [Sata, Masataka] Univ Tokushima, Inst Hlth Biosci, Dept Cardiovasc Med, Grad Sch, Tokushima, Japan.
   [Ishibashi, Yutaka] Shimane Univ, Dept Gen Med, Fac Med, Matsue, Shimane, Japan.
   [Node, Koichi] Saga Univ, Dept Cardiovasc Med, Saga, Japan.
   [Maemura, Koji] Nagasaki Univ, Grad Sch Biomed Sci, Dept Cardiovasc Med Course Med & Dent Sci, Nagasaki, Japan.
   [Ohya, Yusuke] Univ Ryukyus, Dept Internal Med 3, Nishihara, Okinawa, Japan.
   [Furukawa, Taiji] Teikyo Univ, Dept Internal Med, Sch Med, Tokyo, Japan.
   [Ito, Hiroshi] Okayama Univ, Dept Cardiovasc Med, Grad Sch Med Dent & Pharmaceut Sci, Okayama, Japan.
   [Higashi, Yukihito] Hiroshima Univ, Res Inst Radiat Biol & Med, Dept Regenerat Med, Hiroshima, Japan.
   [Masaki, Nobuyuki] Natl Def Med Coll, Dept Intens Care Med, 3-2 Namiki, Tokorozawa, Saitama 3528165, Japan.
C3 National Defense Medical College - Japan; National Defense Medical
   College - Japan; Tokyo Medical University; Jichi Medical University;
   University of Leicester; University of Tsukuba; University of the
   Ryukyus; University of Tokyo; Hokkaido University; Jichi Medical
   University; Dokkyo Medical University; Showa University; Osaka
   Metropolitan University; Wakayama Medical University; Tokushima
   University; Shimane University; Saga University; Nagasaki University;
   University of the Ryukyus; Teikyo University; Okayama University;
   Hiroshima University; National Defense Medical College - Japan
RP Masaki, N (corresponding author), Natl Def Med Coll, Dept Intens Care Med, 3-2 Namiki, Tokorozawa, Saitama 3528165, Japan.
EM masakinobuyuki@hotmail.com
RI Ishizu, Tomoko/IAO-5630-2023; Ohya, Yukihiro/Y-9002-2019; Sata,
   Masataka/IST-9041-2023
FU Atherosclerosis Prevention Fund; Ministry of Education, Culture, Sports,
   Science and Technology of Japan [20 K08503]; Grants-in-Aid for
   Scientific Research [23K24330, 23K24329] Funding Source: KAKEN
FX This study was supported, in part, by a Grant-in- Aid from the Japanese.
   Atherosclerosis Prevention Fund. The work was supported by a Grant- in-
   aid for Scientific Research from the Ministry of Education, Culture,
   Sports, Science and Technology of Japan (20 K08503 to Masaki N).
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NR 54
TC 0
Z9 0
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2051-817X
J9 PHYSIOL REP
JI PHYSIOL. REP.
PD AUG
PY 2023
VL 11
IS 16
AR e15786
DI 10.14814/phy2.15786
PG 15
WC Physiology
WE Emerging Sources Citation Index (ESCI)
SC Physiology
GA P7TU2
UT WOS:001052668500001
PM 37607768
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU He, QQ
   Qu, MY
   Shen, TY
   Su, JK
   Xu, YN
   Xu, CY
   Barkat, MQ
   Cai, JB
   Zhu, HB
   Zeng, LH
   Wu, XM
AF He, Qiangqiang
   Qu, Meiyu
   Shen, Tingyu
   Su, Jiakun
   Xu, Yana
   Xu, Chengyun
   Barkat, Muhammad Qasim
   Cai, Jibao
   Zhu, Haibin
   Zeng, Ling -Hui
   Wu, Ximei
TI Control of mitochondria-associated endoplasmic reticulum membranes by
   protein S-palmitoylation: Novel therapeutic targets for
   neurodegenerative diseases
SO AGEING RESEARCH REVIEWS
LA English
DT Review
DE MAMs; S-palmitoylation; Ca2+; Lipid rafts; Neurodegenerative diseases
ID PHOSPHATIDYLSERINE DECARBOXYLASE; ER MEMBRANES;
   INTRACELLULAR-LOCALIZATION; SACCHAROMYCES-CEREVISIAE; ACYLTRANSFERASE
   DHHC2; CALCIUM HOMEOSTASIS; TUMOR-SUPPRESSOR; FATTY ACYLATION; CA2+;
   RECEPTOR
AB Mitochondria-associated endoplasmic reticulum membranes (MAMs) are dynamic coupling structures between mitochondria and the endoplasmic reticulum (ER). As a new subcellular structure, MAMs combine the two critical organelle functions. Mitochondria and the ER could regulate each other via MAMs. MAMs are involved in calcium (Ca2+) homeostasis, autophagy, ER stress, lipid metabolism, etc. Researchers have found that MAMs are closely related to metabolic syndrome and neurodegenerative diseases (NDs). The formation of MAMs and their functions depend on specific proteins. Numerous protein enrichments, such as the IP3R-Grp75-VDAC complex, constitute MAMs. The changes in these proteins govern the interaction between mitochondria and the ER; they also affect the biological functions of MAMs. S-palmitoylation is a reversible protein post-translational modifi-cation (PTM) that mainly occurs on protein cysteine residues. More and more studies have shown that the S-palmitoylation of proteins is closely related to their membrane localization. Here, we first briefly describe the composition and function of MAMs, reviewing the component and biological roles of MAMs mediated by S-palmitoylation, elaborating on S-palmitoylated proteins in Ca2+ flux, lipid rafts, and so on. We try to provide new insight into the molecular basis of MAMs-related diseases, mainly NDs. Finally, we propose potential drug compounds targeting S-palmitoylation.
C1 [He, Qiangqiang; Qu, Meiyu; Shen, Tingyu; Xu, Yana; Xu, Chengyun; Barkat, Muhammad Qasim; Wu, Ximei] Zhejiang Univ, Dept Pharmacol, Sch Med, Hangzhou 310058, Peoples R China.
   [He, Qiangqiang; Zeng, Ling -Hui] Hangzhou City Univ, Dept Pharmacol, Hangzhou 310015, Peoples R China.
   [Su, Jiakun; Cai, Jibao] China Tobacco Jiangxi Ind Co Ltd, Technol Ctr, Nanchang 330096, Peoples R China.
   [Zhu, Haibin] Zhejiang Univ, Affiliated Hosp 1, Dept Gynecol, Sch Med, Hangzhou 310003, Peoples R China.
   [Zeng, Ling -Hui] Hangzhou City Univ, Dept Pharmacol, 51 Huzhou St, Hangzhou 310015, Peoples R China.
   [Wu, Ximei] Zhejiang Univ, Dept Pharmacol, Sch Med, 866 Yuhangtang Rd, Hangzhou 310058, Peoples R China.
C3 Zhejiang University; Hangzhou City University; China National Tobacco
   Corporation; Zhejiang University; Hangzhou City University; Zhejiang
   University
RP Zeng, LH (corresponding author), Hangzhou City Univ, Dept Pharmacol, 51 Huzhou St, Hangzhou 310015, Peoples R China.; Wu, XM (corresponding author), Zhejiang Univ, Dept Pharmacol, Sch Med, 866 Yuhangtang Rd, Hangzhou 310058, Peoples R China.
EM zenglh@zucc.edu; xiwu@zju.edu.cn
RI Barkat, Muhammad Qasim/JPL-0329-2023
OI Wu, Ximei/0000-0002-3316-893X; He, Qiangqiang/0009-0004-5753-9362
FU National Natural Science Foundation of China [31571493, 81741043,
   31871395, 32170841]; Tobacco Control Program in China [110201401025:
   JH-03]
FX Funding This work was supported by the National Natural Science
   Foundation of China (Nos. 31571493, 81741043, 31871395, and 32170841)
   and Tobacco Control Program in China (110201401025: JH-03) .
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NR 234
TC 25
Z9 27
U1 9
U2 45
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 1568-1637
EI 1872-9649
J9 AGEING RES REV
JI Ageing Res. Rev.
PD JUN
PY 2023
VL 87
AR 101920
DI 10.1016/j.arr.2023.101920
EA APR 2023
PG 14
WC Cell Biology; Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Geriatrics & Gerontology
GA D1LQ5
UT WOS:000966409900001
PM 37004843
DA 2025-06-11
ER

PT J
AU Vetrano, E
   Rinaldi, L
   Mormone, A
   Giorgione, C
   Galiero, R
   Caturano, A
   Nevola, R
   Marfella, R
   Sasso, FC
AF Vetrano, Erica
   Rinaldi, Luca
   Mormone, Andrea
   Giorgione, Chiara
   Galiero, Raffaele
   Caturano, Alfredo
   Nevola, Riccardo
   Marfella, Raffaele
   Sasso, Ferdinando Carlo
TI Non-alcoholic Fatty Liver Disease (NAFLD), Type 2 Diabetes, and
   Non-viral Hepatocarcinoma: Pathophysiological Mechanisms and New
   Therapeutic Strategies
SO BIOMEDICINES
LA English
DT Review
DE nonalcoholic fatty liver disease; type 2 diabetes; hepatocellular
   carcinoma
ID ADVANCED HEPATOCELLULAR-CARCINOMA; DE-NOVO LIPOGENESIS; OBETICHOLIC
   ACID; UNITED-STATES; DOUBLE-BLIND; VITAMIN-E; INSULIN SENSITIVITY;
   1ST-LINE TREATMENT; HEPATIC STEATOSIS; OPEN-LABEL
AB In recent years, the incidence of non-viral hepatocellular carcinoma (HCC) has increased dramatically, which is probably related to the increased prevalence of metabolic syndrome, together with obesity and type 2 diabetes mellitus (T2DM). Several epidemiological studies have established the association between T2DM and the incidence of HCC and have demonstrated the role of diabetes mellitus as an independent risk factor for the development of HCC. The pathophysiological mechanisms underlying the development of Non-alcoholic fatty liver disease (NAFLD) and its progression to Non-alcoholic steatohepatitis (NASH) and cirrhosis are various and involve pro-inflammatory agents, oxidative stress, apoptosis, adipokines, JNK-1 activation, increased IGF-1 activity, immunomodulation, and alteration of the gut microbiota. Moreover, these mechanisms are thought to play a significant role in the development of NAFLD-related hepatocellular carcinoma. Early diagnosis and the timely correction of risk factors are essential to prevent the onset of liver fibrosis and HCC. The purpose of this review is to summarize the current evidence on the association among obesity, NASH/NAFLD, T2DM, and HCC, with an emphasis on clinical impact. In addition, we will examine the main mechanisms underlying this complex relationship, and the promising strategies that have recently emerged for these diseases' treatments.
C1 [Vetrano, Erica; Rinaldi, Luca; Mormone, Andrea; Giorgione, Chiara; Galiero, Raffaele; Caturano, Alfredo; Nevola, Riccardo; Marfella, Raffaele; Sasso, Ferdinando Carlo] Univ Campania Luigi Vanvitelli, Dept Adv Med & Surg Sci, I-80138 Naples, Italy.
C3 Universita della Campania Vanvitelli
RP Sasso, FC (corresponding author), Univ Campania Luigi Vanvitelli, Dept Adv Med & Surg Sci, I-80138 Naples, Italy.
EM ferdinandocarlo.sasso@unicampania.it
RI Sasso, Ferdinando Carlo/AAE-5665-2019; Nevola, Riccardo/AAC-6298-2020;
   Galiero, Raffaele/KTP-8361-2024; Caturano, Alfredo/AAA-4014-2022;
   Marfella, Raffaele/AAH-2595-2019; Caturano, Alfredo/ACM-4169-2022;
   Nevola, Riccardo/G-3257-2018
OI Rinaldi, Luca/0000-0002-6541-3821; Sasso, Ferdinando
   Carlo/0000-0002-9142-7848; Caturano, Alfredo/0000-0001-7761-7533;
   Galiero, Raffaele/0000-0002-7766-3430; marfella,
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NR 175
TC 41
Z9 44
U1 5
U2 48
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2227-9059
J9 BIOMEDICINES
JI Biomedicines
PD FEB
PY 2023
VL 11
IS 2
AR 468
DI 10.3390/biomedicines11020468
PG 19
WC Biochemistry & Molecular Biology; Medicine, Research & Experimental;
   Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Research & Experimental Medicine;
   Pharmacology & Pharmacy
GA 9G7YK
UT WOS:000938363500001
PM 36831004
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Ruhee, RT
   Roberts, LA
   Ma, SH
   Suzuki, K
AF Ruhee, Ruheea Taskin
   Roberts, Llion Arwyn
   Ma, Sihui
   Suzuki, Katsuhiko
TI Organosulfur Compounds: A Review of Their Anti-inflammatory Effects in
   Human Health
SO FRONTIERS IN NUTRITION
LA English
DT Review
DE organosulfur compounds; inflammation; chronic diseases; cytokines;
   NF-kappa B
ID NF-KAPPA-B; NATURALLY-OCCURRING ISOTHIOCYANATE; ALLYL METHYL SULFIDE;
   NITRIC-OXIDE; DIALLYL TRISULFIDE; METABOLIC SYNDROME; COX-2 EXPRESSION;
   OXIDATIVE STRESS; GARLIC OIL; TNF-ALPHA
AB Phytonutrients are widely recognized for providing protective human health benefits. Among the phytonutrients, epidemiological and experimental studies show that dietary organosulfur compounds (OSC) play a significant role in preventing various human pathological progressions, including chronic inflammation, by decreasing inflammatory mediators such as nitric oxide (NO), prostaglandin (PG)E-2, interleukin (IL)-1 beta, IL-6, tumor necrosis factor (TNF)-alpha, and IL-17, which are all typical hallmarks of inflammation. Evidence supports OSC in reducing the expression of these markers, thereby attenuating chronic inflammatory processes. Nuclear factor-kappa B (NF-kappa B) is a key regulating factor during inflammation, and novel evidence shows that OSC downregulates this transcriptional factor, thus contributing to the anti-inflammatory response.In vitroandin vivostudies show that inflammation is mechanistically linked with acute and chronic pathological conditions including cancer, diabetes, obesity, neural dysfunction, etc. Furthermore, a considerable number of experiments have demonstrated that the anti-inflammatory properties of OSC occur in a dose-dependent manner. These experiments also highlight indirect mechanisms as well as potent co-functions for protective roles as antioxidants, and in providing chemoprotection and neuroprotection. In this brief review, we provided an overview of the anti-inflammatory effects of OSC and elucidated probable mechanisms that are associated with inflammation and chronic disorders.
C1 [Ruhee, Ruheea Taskin] Waseda Univ, Grad Sch Sport Sci, Tokorozawa, Saitama, Japan.
   [Roberts, Llion Arwyn] Griffith Univ, Sch Allied Hlth Sci, Gold Coast, Qld, Australia.
   [Roberts, Llion Arwyn] Univ Queensland, Sch Human Movement & Nutr Sci, Brisbane, Qld, Australia.
   [Ma, Sihui; Suzuki, Katsuhiko] Waseda Univ, Fac Sport Sci, Tokorozawa, Saitama, Japan.
C3 Waseda University; Griffith University; Griffith University - Gold Coast
   Campus; University of Queensland; Waseda University
RP Suzuki, K (corresponding author), Waseda Univ, Fac Sport Sci, Tokorozawa, Saitama, Japan.
EM katsu.suzu@waseda.jp
RI Ma, Sihui/W-7291-2019; Roberts, Llion/AAF-9393-2020; Roberts,
   Llion/E-6593-2012
OI Roberts, Llion/0000-0002-2284-1033
FU Waseda University [2019Q-056]
FX This work was partly supported by the Waseda University Grant for
   Special Research Projects 2019Q-056.
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NR 129
TC 84
Z9 87
U1 2
U2 24
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD JUN 2
PY 2020
VL 7
AR 64
DI 10.3389/fnut.2020.00064
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA MH8LI
UT WOS:000546973200001
PM 32582751
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Ma, ZG
   Kong, CY
   Song, P
   Zhang, X
   Yuan, YP
   Tang, QZ
AF Ma, Zhen-Guo
   Kong, Chun-Yan
   Song, Peng
   Zhang, Xin
   Yuan, Yu-Pei
   Tang, Qi-Zhu
TI Geniposide Protects against Obesity-Related Cardiac Injury through
   AMPKα- and Sirt1-Dependent Mechanisms
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Article
ID OXIDATIVE STRESS; HEART-DISEASE; FATTY-ACIDS; CELL-DEATH; INFLAMMATION;
   PATHOPHYSIOLOGY; HYPERTROPHY; DYSFUNCTION; CARDIOMYOPATHY; TRANSCRIPTION
AB Our previous study found that geniposide, an agonist of glucagon-like peptide-1 receptor (GLP-1R), protected against cardiac hypertrophy via the activation of AMP-activated protein kinase alpha (AMPK alpha). However, the effects of geniposide on obesity-related cardiac injury remain unknown. Here, we examine whether geniposide attenuates obesity-related cardiac dysfunction. Adult mice were fed a high-fat diet (HFD) for 24 weeks to induce obesity, with the last 3 weeks including a 21-day treatment with geniposide. Morphological changes, cardiac function, and remodeling were assessed. HFD-induced metabolic syndrome, featured as obesity, hyperglycemia, and cardiac hypertrophy, was prevented by geniposide treatment. Geniposide preserved cardiac function in the obese mice. Furthermore, geniposide attenuated myocardial inflammation and myocyte apoptosis induced by HFD. Geniposide activated AMPK alpha and sirtuin (Sirt1) in vivo and in vitro. Ampk alpha deficiency reversed the inhibitory effects of geniposide on cell loss. Sirt1 deficiency abolished the inhibitory effects of geniposide on inflammation in the cardiomyocytes. Geniposide completely lost its protective effects on Ampk alpha knockout mice after Sirt1 deficiency achieved by a nanoparticle transfection reagent. The activation of Sirt1 by geniposide was abolished by Glp-1r deficiency in vitro. Geniposide reverses molecular pathology and cardiac dysfunction via both AMPK alpha- and Sirt1-dependent mechanisms. Geniposide is a potential therapeutic drug for cardiovascular complications induced by obesity.
C1 [Ma, Zhen-Guo; Kong, Chun-Yan; Song, Peng; Zhang, Xin; Yuan, Yu-Pei; Tang, Qi-Zhu] Wuhan Univ, Dept Cardiol, Renmin Hosp, Wuhan 430060, Hubei, Peoples R China.
   [Ma, Zhen-Guo; Kong, Chun-Yan; Song, Peng; Zhang, Xin; Yuan, Yu-Pei; Tang, Qi-Zhu] Wuhan Univ, Cardiovasc Res Inst, Wuhan 430060, Hubei, Peoples R China.
   [Ma, Zhen-Guo; Kong, Chun-Yan; Song, Peng; Zhang, Xin; Yuan, Yu-Pei; Tang, Qi-Zhu] Hubei Key Lab Cardiol, Wuhan 430060, Hubei, Peoples R China.
C3 Wuhan University; Wuhan University
RP Tang, QZ (corresponding author), Wuhan Univ, Dept Cardiol, Renmin Hosp, Wuhan 430060, Hubei, Peoples R China.; Tang, QZ (corresponding author), Wuhan Univ, Cardiovasc Res Inst, Wuhan 430060, Hubei, Peoples R China.; Tang, QZ (corresponding author), Hubei Key Lab Cardiol, Wuhan 430060, Hubei, Peoples R China.
EM qztang@whu.edu.cn
RI Zhang, Xin/GMW-9575-2022
FU National Natural Science Foundation of China [81470402, 81500184,
   81700254]; National Natural Science Foundation [81530012]; Fundamental
   Research Funds for the Central Universities [2042017kf0085]
FX This work was supported by grants from the National Natural Science
   Foundation of China (nos. 81470402, 81500184, and 81700254), the Key
   Project of the National Natural Science Foundation (no. 81530012), and
   the Fundamental Research Funds for the Central Universities (no.
   2042017kf0085).
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NR 34
TC 36
Z9 40
U1 4
U2 23
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PY 2018
VL 2018
AR 6053727
DI 10.1155/2018/6053727
PG 12
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA HB0RY
UT WOS:000450726400001
PM 30533173
OA Green Published, hybrid, Green Submitted
DA 2025-06-11
ER

PT J
AU Bahado-Singh, RO
   Syngelaki, A
   Mandal, R
   Graham, SF
   Akolekar, R
   Han, B
   Bjondahl, TC
   Dong, E
   Bauer, S
   Alpay-Savasan, Z
   Turkoglu, O
   Ogunyemi, D
   Poon, LC
   Wishart, DS
   Nicolaides, KH
AF Bahado-Singh, Ray O.
   Syngelaki, Argyro
   Mandal, Rupsari
   Graham, Stewart F.
   Akolekar, Ranjit
   Han, Beomsoo
   Bjondahl, Trent C.
   Dong, Edison
   Bauer, Samuel
   Alpay-Savasan, Zeynep
   Turkoglu, Onur
   Ogunyemi, Dotun
   Poon, Liona C.
   Wishart, David S.
   Nicolaides, Kypros H.
TI Metabolomic determination of pathogenesis of late-onset preeclampsia
SO JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
LA English
DT Article
DE Insulin resistance; metabolomics; preeclampsia
ID 1ST-TRIMESTER PREDICTION; PLACENTAL TRANSPORT; THERAPEUTIC TARGETS;
   INSULIN-RESISTANCE; PREGNANT-WOMEN; METABOANALYST; HYPERTENSION;
   METFORMIN; HMDB; HYPERINSULINEMIA
AB Objective: Our primary objective was to apply metabolomic pathway analysis of first trimester maternal serum to provide an insight into the pathogenesis of late-onset preeclampsia (late-PE) and thereby identify plausible therapeutic targets for PE.
   Methods: NMR-based metabolomics analysis was performed on 29 cases of late-PE and 55 unaffected controls. In order to achieve sufficient statistical power to perform the pathway analysis, these cases were combined with a group of previously analyzed specimens, 30 late-PE cases and 60 unaffected controls. Specimens from both groups of cases and controls were collected in the same clinical centers during the same time period. In addition, NMR analyses were performed in the same lab and using the same techniques.
   Results: We identified abnormalities in branch chain amino acids (valine, leucine and isoleucine) and propanoate, glycolysis, gluconeogenesis and ketone body metabolic pathways. The results suggest insulin resistance and metabolic syndrome, mitochondrial dysfunction and disturbance of energy metabolism, oxidative stress and lipid dysfunction in the pathogenesis of late PE and suggest a potential role for agents that reduce insulin resistance in PE.
   Conclusions: Branched chain amino acids are known markers of insulin resistance and strongly predict future diabetes development. The analysis provides independent evidence linking insulin resistance and late-PE and suggests a potentially important therapeutic role for pharmacologic agents that reduce insulin resistance for late-PE.
C1 [Bahado-Singh, Ray O.; Graham, Stewart F.; Bauer, Samuel; Alpay-Savasan, Zeynep; Turkoglu, Onur; Ogunyemi, Dotun] Beaumont Hlth, Dept Obstet & Gynecol, Royal Oak, MI USA.
   [Syngelaki, Argyro; Akolekar, Ranjit; Poon, Liona C.; Nicolaides, Kypros H.] Kings Coll Hosp London, Div Womens Hlth, Harris Birthright Res Ctr Fetal Med, London, England.
   [Mandal, Rupsari; Han, Beomsoo; Bjondahl, Trent C.; Dong, Edison; Wishart, David S.] Univ Alberta, Dept Biol Sci, Edmonton, AB, Canada.
   [Wishart, David S.] Univ Alberta, Dept Comp Sci, Edmonton, AB, Canada.
C3 Beaumont Health; King's College Hospital NHS Foundation Trust; King's
   College Hospital; University of London; King's College London;
   University of Alberta; University of Alberta
RP Bahado-Singh, RO (corresponding author), William Beaumont Hlth, Dept Obstet & Gynecol, 3535 W 13 Mile Rd,Suite 233, Royal Oak, MI 48073 USA.
EM ray.bahado-singh@beaumont.org
RI Akolekar, Ranjit/IAM-2555-2023; Graham, Stewart/AAE-9772-2020; Wishart,
   David/ABI-3181-2020; Poon, Liona C./P-9311-2017
OI Poon, Liona C./0000-0002-3944-4130; Nicolaides,
   Kypros/0000-0003-1266-0711; Graham, Stewart/0000-0003-1001-0002;
   Syngelaki, Argyro/0000-0001-5856-6072
FU Fetal Medicine Foundation (UK Charity) [1037116]
FX This work was partially supported by a grant from the Fetal Medicine
   Foundation (UK Charity No: 1037116).
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NR 44
TC 40
Z9 43
U1 0
U2 16
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1476-7058
EI 1476-4954
J9 J MATERN-FETAL NEO M
JI J. Matern.-Fetal Neonatal Med.
PD MAR
PY 2017
VL 30
IS 6
BP 658
EP 664
DI 10.1080/14767058.2016.1185411
PG 7
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA EJ5ZI
UT WOS:000393297500005
PM 27569705
DA 2025-06-11
ER

PT J
AU Rosen, ED
AF Rosen, E. D.
TI Epigenomic and transcriptional control of insulin resistance
SO JOURNAL OF INTERNAL MEDICINE
LA English
DT Article
DE adipocyte; chromatin-modifying enzyme; insulin resistance; transcription
   factor; transcriptional cofactor; type 2 diabetes
ID ACTIVATED-RECEPTOR-GAMMA; HEPATIC GLUCOSE OUTPUT; PPAR-GAMMA;
   GLUCOCORTICOID-RECEPTOR; SKELETAL-MUSCLE; ANTIDIABETIC ACTIONS;
   COACTIVATOR TORC2; PROMOTES OBESITY; GENE-EXPRESSION; BINDING
AB Insulin resistance is one of the defining features of type 2 diabetes and the metabolic syndrome and accompanies many other clinical conditions, ranging from obesity to lipodystrophy to glucocorticoid excess. Extraordinary efforts have gone into defining the mechanisms that underlie insulin resistance, with most attention focused on altered signalling as well as mitochondrial and endoplasmic reticulum stress. Here, nuclear mechanisms of insulin resistance, including transcriptional and epigenomic effects, will be discussed. Three levels of control involving transcription factors, transcriptional cofactors, and chromatin-modifying enzymes will be considered. Well-studied examples of the first include PPAR- in adipose tissue and the glucocorticoid receptor and FoxO1 in a variety of insulin-sensitive tissues. These proteins work in concert with cofactors such as PGC-1 and CRTC2, and chromatin-modifying enzymes including DNA methyltransferases and histone acetyltransferases, to regulate key genes that promote insulin-stimulated glucose uptake, gluconeogenesis or other pathways that affect systemic insulin action. Furthermore, genetic variation associated with increased risk of type 2 diabetes is often related to altered transcription factor binding, either by affecting the transcription factor itself, or more commonly by changing the binding affinity of a noncoding regulatory region. Finally, several avenues for therapeutic exploitation in the battle against metabolic disease will be discussed, including small-molecule inhibitors and activators of these factors and their related pathways.
C1 [Rosen, E. D.] Beth Israel Deaconess Med Ctr, Div Endocrinol & Metab, 330 Brookline Ave, Boston, MA 02215 USA.
   [Rosen, E. D.] Harvard Med Sch, 330 Brookline Ave, Boston, MA 02215 USA.
C3 Harvard University; Harvard University Medical Affiliates; Beth Israel
   Deaconess Medical Center; Harvard University; Harvard Medical School
RP Rosen, ED (corresponding author), Beth Israel Deaconess Med Ctr, Div Endocrinol & Metab, 330 Brookline Ave, Boston, MA 02215 USA.; Rosen, ED (corresponding author), Harvard Med Sch, 330 Brookline Ave, Boston, MA 02215 USA.
EM erosen@bidmc.harvard.edu
FU NIH [R01 DK 085171, R01 DK 102173, R01 DK 102170]
FX The author is supported by NIH grants R01 DK 085171, R01 DK 102173 and
   R01 DK 102170.
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NR 115
TC 22
Z9 24
U1 0
U2 8
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0954-6820
EI 1365-2796
J9 J INTERN MED
JI J. Intern. Med.
PD NOV
PY 2016
VL 280
IS 5
BP 443
EP 456
DI 10.1111/joim.12547
PG 14
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA EA8VL
UT WOS:000386917400003
PM 27739225
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Tan, Y
   Liu, XR
   Zhou, K
   He, XJ
   Lu, C
   He, B
   Niu, XY
   Xiao, C
   Xu, G
   Bian, ZX
   Zu, XP
   Zhang, G
   Zhang, WD
   Lu, AP
AF Tan, Yong
   Liu, Xinru
   Zhou, Ke
   He, Xiaojuan
   Lu, Cheng
   He, Bing
   Niu, Xuyan
   Xiao, Cheng
   Xu, Gang
   Bian, Zhaoxiang
   Zu, Xianpeng
   Zhang, Ge
   Zhang, Weidong
   Lu, Aiping
TI The Potential Biomarkers to Identify the Development of Steatosis in
   Hyperuricemia
SO PLOS ONE
LA English
DT Article
ID FATTY LIVER-DISEASE; SERUM URIC-ACID; TRADITIONAL CHINESE MEDICINE;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; METABOLIC SYNDROME;
   PHOSPHOLIPASE-D; ANTIOXIDANT CAPACITY; PHOSPHATIDIC-ACID; RADIX-ACONITI
AB Hyperuricemia (HU) often progresses to combine with non-alcoholic fatty liver disease (NAFLD) in the clinical scenario, which further exacerbates metabolic disorders; early detection of biomarkers, if obtained during the HU progression, may be beneficial for preventing its combination with NAFLD. This study aimed to decipher the biomarkers and mechanisms of the development of steatosis in HU. Four groups of subjects undergoing health screening, including healthy subjects, subjects with HU, subjects with HU combined with NAFLD (HU+NAFLD) and subjects with HU initially and then with HU+NAFLD one year later (HU -> HU+NAFLD), were recruited in this study. The metabolic profiles of all subjects' serum were analyzed by liquid chromatography quadruple time-of-flight mass spectrometry. The metabolomic data from subjects with HU and HU+NAFLD were compared, and the biomarkers for the progression from HU to HU+NAFLD were predicted. The metabolomic data from HU -> HU+NAFLD subjects were collected for further verification. The results showed that the progression was associated with disturbances of phospholipase metabolism, purine nucleotide degradation and Liver X receptor/retinoic X receptor activation as characterized by up-regulated phosphatidic acid, cholesterol ester (18:0) and down-regulated inosine. These metabolic alterations may be at least partially responsible for the development of steatosis in HU. This study provides a new paradigm for better understanding and further prevention of disease progression.
C1 [Tan, Yong; He, Xiaojuan; Lu, Cheng; Niu, Xuyan; Lu, Aiping] China Acad Chinese Med Sci, Inst Basic Res Clin Med, Beijing, Peoples R China.
   [Liu, Xinru; Zu, Xianpeng; Zhang, Weidong] Second Mil Med Univ, Sch Pharm, Shanghai, Peoples R China.
   [Zhou, Ke] Hunan Univ Chinese Med, Affiliated Hosp 2, Changsha, Hunan, Peoples R China.
   [He, Bing; Xu, Gang; Bian, Zhaoxiang; Zhang, Ge; Zhang, Weidong; Lu, Aiping] Hong Kong Baptist Univ, Sch Chinese Med, Inst Adv Translat Med Bone & Joint Dis, Hong Kong, Hong Kong, Peoples R China.
   [Xiao, Cheng] China Japan Friendship Hosp, Beijing, Peoples R China.
   [Lu, Aiping] Shanghai Municipal Educ Commiss, E Inst, Shanghai, Peoples R China.
C3 China Academy of Chinese Medical Sciences; Institute of Basic Research
   In Clinical Medicine, CACMS; Naval Medical University; Hunan University
   of Chinese Medicine; Hong Kong Baptist University; China-Japan
   Friendship Hospital; Shanghai Municipal Education Commission (SHMEC)
RP Lu, AP (corresponding author), China Acad Chinese Med Sci, Inst Basic Res Clin Med, Beijing, Peoples R China.; Zhang, WD (corresponding author), Second Mil Med Univ, Sch Pharm, Shanghai, Peoples R China.; Zhang, G; Lu, AP (corresponding author), Hong Kong Baptist Univ, Sch Chinese Med, Inst Adv Translat Med Bone & Joint Dis, Hong Kong, Hong Kong, Peoples R China.; Lu, AP (corresponding author), Shanghai Municipal Educ Commiss, E Inst, Shanghai, Peoples R China.
EM zhangge@hkbu.edu.hk; wdzhangy@hotmail.com; aipinglu@hkbu.edu.hk
RI Zhang, Weidong/U-5976-2019; LU, Aiping/JDX-0577-2023; Zu,
   Xian-peng/AAW-6011-2021; He, Bing/AFX-5191-2022; Liu,
   Xinru/KEH-2341-2024; Xiao, Cheng/AAM-7764-2020; Zhang, Ge/N-4150-2013
OI xiao, Cheng/0000-0002-5601-9670; He, Bing/0000-0003-1719-9290
FU National Science Foundation of China [81230090]; Hong Kong Baptist
   University Strategic Development Fund [SDF13-1209-P01];
   Interdisciplinary Research Matching Scheme of Hong Kong Baptist
   University [RC-IRMS/12-13/02]; China Postdoctoral Science Foundation
   [2013M541158]; E-Institutes of the Shanghai Municipal Education
   Commission [E03008]; Professor of Chang Jiang Scholars Program
FX This study was supported by the following sources of funding: National
   Science Foundation of China (no. 81230090; http://npd.nsfc.gov.cn/), the
   author who received the funding: WDZ; Hong Kong Baptist University
   Strategic Development Fund (no. SDF13-1209-P01;
   http://scm.hkbu.edu.hk/tc/home/index.php), the author who received the
   funding: APL; Interdisciplinary Research Matching Scheme of Hong Kong
   Baptist University (no. RC-IRMS/12-13/02;
   http://scm.hkbu.edu.hk/tc/home/index.php), the author who received the
   funding: APL; China Postdoctoral Science Foundation (no. 2013M541158;
   http://www.chinapostdoctor.org.cn/), the author who received the
   funding: KZ; E-Institutes of the Shanghai Municipal Education Commission
   (no. E03008; http://www.shmec.gov.cn/), the author who received the
   funding: WDZ; the Professor of Chang Jiang Scholars Program
   (http://www.moe.edu.cn/publicfiles/business/htmlfiles/moe/A04_ndgzyd/),
   the author who received the funding: WDZ.
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NR 51
TC 14
Z9 15
U1 0
U2 38
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD FEB 18
PY 2016
VL 11
IS 2
AR e0149043
DI 10.1371/journal.pone.0149043
PG 18
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA DF3CO
UT WOS:000371221500021
PM 26890003
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Martins, IJ
AF Martins, Ian James
TI Overnutrition Determines LPS Regulation of Mycotoxin Induced
   Neurotoxicity in Neurodegenerative Diseases
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE cholesterol; mycotoxin; amyloid beta; apolipoprotein E; dyslipidemia;
   insulin resistance; Alzheimer's disease; lipopolysaccarides; liver;
   brain
ID BLOOD-BRAIN-BARRIER; AMYLOID-BETA-PEPTIDE; LOW-DENSITY-LIPOPROTEIN;
   PHOSPHOLIPID TRANSFER PROTEIN; APOLIPOPROTEIN B48 TRANSPORT;
   NITRIC-OXIDE PRODUCTION; OXIDATIVE STRESS; CHOLESTEROL EFFLUX;
   ALPHA-SYNUCLEIN; COUPLED RECEPTORS
AB Chronic neurodegenerative diseases are now associated with obesity and diabetes and linked to the developing and developed world. Interests in healthy diets have escalated that may prevent neurodegenerative diseases such as Parkinson's and Alzheimer's disease. The global metabolic syndrome involves lipoprotein abnormalities and insulin resistance and is the major disorder for induction of neurological disease. The effects of bacterial lipopolysaccharides (LPS) on dyslipidemia and NAFLD indicate that the clearance and metabolism of fungal mycotoxins are linked to hypercholesterolemia and amyloid beta oligomers. LPS and mycotoxins are associated with membrane lipid disturbances with effects on cholesterol interacting proteins, lipoprotein metabolism, and membrane apo E/amyloid beta interactions relevant to hypercholesterolemia with close connections to neurological diseases. The influence of diet on mycotoxin metabolism has accelerated with the close association between mycotoxin contamination from agricultural products such as apple juice, grains, alcohol, and coffee. Cholesterol efflux in lipoproteins and membrane cholesterol are determined by LPS with involvement of mycotoxin on amyloid beta metabolism. Nutritional interventions such as diets low in fat/carbohydrate/cholesterol have become of interest with relevance to low absorption of lipophilic LPS and mycotoxin into lipoproteins with rapid metabolism of mycotoxin to the liver with the prevention of neurodegeneration.
C1 [Martins, Ian James] Edith Cowan Univ, Sch Med Sci, Ctr Excellence Alzheimers Dis Res & Care, Joondalup 6027, Australia.
   [Martins, Ian James] Univ Western Australia, Sch Psychiat & Clin Neurosci, Nedlands, WA 6009, Australia.
   [Martins, Ian James] McCusker Alzheimers Res Fdn, Hollywood Med Ctr, Nedlands, WA 6009, Australia.
C3 Edith Cowan University; University of Western Australia
RP Martins, IJ (corresponding author), Edith Cowan Univ, Sch Med Sci, Ctr Excellence Alzheimers Dis Res & Care, 270 Joondalup Dr, Joondalup 6027, Australia.
EM i.martins@ecu.edu.au
RI Martins, Isabel/KIE-5762-2024
OI Martins, Ian James/0000-0002-2390-1501
FU Edith Cowan University; McCusker Alzheimer's Research Foundation;
   National Health and Medical Research Council
FX ~ This work was supported by grants from Edith Cowan University, the
   McCusker Alzheimer's Research Foundation, and the National Health and
   Medical Research Council.
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NR 211
TC 29
Z9 32
U1 1
U2 33
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD DEC
PY 2015
VL 16
IS 12
BP 29554
EP 29573
DI 10.3390/ijms161226190
PG 20
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA DA1DD
UT WOS:000367535600102
PM 26690419
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Takir, M
   Kostek, O
   Ozkok, A
   Elcioglu, OC
   Bakan, A
   Erek, A
   Mutlu, HH
   Telci, O
   Semerci, A
   Odabas, AR
   Afsar, B
   Smits, G
   ALanaspa, M
   Sharma, S
   Johnson, RJ
   Kanbay, M
AF Takir, Mumtaz
   Kostek, Osman
   Ozkok, Abdullah
   Elcioglu, Omer Celal
   Bakan, Ali
   Erek, Aybala
   Mutlu, Hasan Huseyin
   Telci, Ozge
   Semerci, Aysun
   Odabas, Ali Riza
   Afsar, Baris
   Smits, Gerard
   ALanaspa, Miguel
   Sharma, Shailendra
   Johnson, Richard J.
   Kanbay, Mehmet
TI Lowering Uric Acid With Allopurinol Improves Insulin Resistance and
   Systemic Inflammation in Asymptomatic Hyperuricemia
SO JOURNAL OF INVESTIGATIVE MEDICINE
LA English
DT Article
DE uric acid; allopurinol; insulin resistance; inflammation
ID EXCESSIVE FRUCTOSE INTAKE; METABOLIC SYNDROME; OXIDATIVE STRESS;
   GLOMERULAR HYPERTENSION; POTENTIAL-ROLE; FATTY-LIVER; GLUCOSE; OBESITY;
   SIGNAL; RATS
AB Background Hyperuricemia is an independent predictor of impaired fasting glucose and type 2 diabetes, but whether it has a causal role in insulin resistance remains controversial. Here we tested the hypothesis that lowering uric acid in hyperuricemic nondiabetic subjects might improve insulin resistance.
   Methods Subjects with asymptomatic hyperuricemia (n = 73) were prospectively placed on allopurinol (n = 40) or control (n = 33) for 3 months. An additional control group consisted of 48 normouricemic subjects. Serum uric acid, fasting glucose, fasting insulin, HOMA-IR (homeostatic model assessment of insulin resistance), and high-sensitivity C-reactive protein were measured at baseline and at 3 months.
   Results Allopurinol-treated subjects showed a reduction in serum uric acid in association with improvement in fasting blood glucose, fasting insulin, and HOMA-IR index, as well as a reduction in serum high-sensitivity C-reactive protein. The number of subjects with impaired fasting glucose significantly decreased in the allopurinol group at 3 months compared with baseline (n = 8 [20%] vs n = 30 [75%], 3 months vs baseline, P < 0.001). In the hyperuricemic control group, only glucose decreased significantly and, in the normouricemic control, no end point changed.
   Conclusions Allopurinol lowers uric acid and improves insulin resistance and systemic inflammation in asymptomatic hyperuricemia. Larger clinical trials are recommended to determine if lowering uric acid can help prevent type 2 diabetes.
C1 [Takir, Mumtaz] Istanbul Medeniyet Univ, Goztepe Training & Res Hosp, Dept Med, Div Endocrinol, Istanbul, Turkey.
   [Kostek, Osman; Telci, Ozge; Semerci, Aysun] Istanbul Medeniyet Univ, Goztepe Training & Res Hosp, Dept Med, Istanbul, Turkey.
   [Ozkok, Abdullah; Elcioglu, Omer Celal; Bakan, Ali; Odabas, Ali Riza] Istanbul Medeniyet Univ, Goztepe Training & Res Hosp, Dept Med, Div Nephrol, Istanbul, Turkey.
   [Erek, Aybala] Istanbul Medeniyet Univ, Goztepe Training & Res Hosp, Dept Biochem, Istanbul, Turkey.
   [Mutlu, Hasan Huseyin] Istanbul Medeniyet Univ, Goztepe Training & Res Hosp, Dept Family Med, Istanbul, Turkey.
   [Afsar, Baris] Konya Numune State Hosp, Div Nephrol, Dept Med, Konya, Turkey.
   [Smits, Gerard; ALanaspa, Miguel; Sharma, Shailendra; Johnson, Richard J.] Univ Colorado, Div Renal Dis & Hypertens, Denver, CO 80202 USA.
   [Kanbay, Mehmet] Koc Univ, Div Nephrol, Dept Med, Sch Med, Istanbul, Turkey.
C3 Istanbul Goztepe Training & Research Hospital; Istanbul Medeniyet
   University; Istanbul Goztepe Training & Research Hospital; Istanbul
   Medeniyet University; Istanbul Medeniyet University; Istanbul Goztepe
   Training & Research Hospital; Istanbul Goztepe Training & Research
   Hospital; Istanbul Medeniyet University; Istanbul Goztepe Training &
   Research Hospital; Istanbul Medeniyet University; Konya Numune Hospital;
   University of Colorado System; University of Colorado Denver; Koc
   University
RP Takir, M (corresponding author), Goztepe Training & Res Hosp, Dept Med, Div Endocrinol, Istanbul, Turkey.
EM mumtaztakir@yahoo.com
RI Sharma, Shailendra/JFJ-5002-2023; Köstek, Osman/AAA-3604-2019; Mutlu,
   Hasan/C-7581-2016; 1, 1/L-6277-2019; Elcioglu, Omer Celal/GYU-8732-2022;
   Caklili, Ozge/AAT-7733-2020; Elcioglu, Omer Celal/AAZ-2707-2020
OI Kostek, Osman/0000-0002-1901-5603; Elcioglu, Omer
   Celal/0000-0001-5943-0302
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NR 42
TC 130
Z9 141
U1 2
U2 29
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1081-5589
EI 1708-8267
J9 J INVEST MED
JI J. Invest. Med.
PD DEC
PY 2015
VL 63
IS 8
BP 924
EP 929
DI 10.1097/JIM.0000000000000242
PG 6
WC Medicine, General & Internal; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Research & Experimental Medicine
GA CX4QQ
UT WOS:000365685800012
PM 26571421
DA 2025-06-11
ER

PT J
AU Nishimukai, M
   Maeba, R
   Yamazaki, Y
   Nezu, T
   Sakurai, T
   Takahashi, Y
   Hui, SP
   Chiba, H
   Okazaki, T
   Hara, H
AF Nishimukai, Megumi
   Maeba, Ryouta
   Yamazaki, Yuya
   Nezu, Toru
   Sakurai, Toshihiro
   Takahashi, Yuji
   Hui, Shu-Ping
   Chiba, Hitoshi
   Okazaki, Tomoki
   Hara, Hiroshi
TI Serum choline plasmalogens, particularly those with oleic acid in sn-2,
   are associated with proatherogenic state
SO JOURNAL OF LIPID RESEARCH
LA English
DT Article
DE ether glycerophospholipid; high density lipoprotein-cholesterol;
   atherosclerosis; serum biomarker
ID HIGH-DENSITY-LIPOPROTEIN; PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE;
   TANDEM MASS-SPECTROMETRY; FATTY LIVER-DISEASE; CHOLESTEROL EFFLUX;
   ALZHEIMERS-DISEASE; METABOLIC SYNDROME; VINYL ETHER; PPAR-ALPHA;
   DEFICIENCY
AB Serum plasmalogens (Pls) (1-O-alk-1'-enyl-2-acyl glycerophospholipids) are of particular interest for studies on metabolic disorders associated with oxidative stress and chronic inflammation. Serum levels of Pls are known to correlate positively with HDL-cholesterol (HDL-C); however, few studies have examined serum Pls molecular species in association with pathophysiological conditions and their clinical significance. To clarify these, we determined serum levels of individual ether glycerophospholipids in Japanese asymptomatic cohorts (n = 428; 362 male and 66 female subjects) by LC/MS/MS, and examined their correlations with clinical parameters. We found that the proportion of choline Pls (PlsCho) among total serum phospholipids was significantly lower in the male group over 40 years old and was associated with multiple risk parameters more strongly than HDL-C. The abundance of serum PlsCho with oleic acid (18:1) in sn-2 exhibited the strongest positive correlation with serum concentrations of adiponectin and HDL-C, while being inversely associated with waist circumference and the serum levels of TG and small dense LDL-cholesterol. The characterization of serum ether glycerophospholipids verified the specificity of PlsCho, particularly the ones with 18:1 in sn-2, as a sensitive biomarker for the atherogenic state.
C1 [Nishimukai, Megumi; Hara, Hiroshi] Hokkaido Univ, Res Fac Agr, Div Appl Biosci, Sapporo, Hokkaido 0608589, Japan.
   [Nishimukai, Megumi] Iwate Univ, Dept Anim Sci, Fac Agr, Morioka, Iwate 0208550, Japan.
   [Maeba, Ryouta; Okazaki, Tomoki] Teikyo Univ, Sch Med, Dept Biochem, Tokyo 1738605, Japan.
   [Yamazaki, Yuya; Nezu, Toru] ADEKA Corp, Food Dev Lab, Tokyo 1168553, Japan.
   [Sakurai, Toshihiro; Takahashi, Yuji; Hui, Shu-Ping; Chiba, Hitoshi] Hokkaido Univ, Fac Hlth Sci, Sapporo, Hokkaido 0600812, Japan.
C3 Hokkaido University; Iwate University; Teikyo University; Hokkaido
   University
RP Maeba, R (corresponding author), Teikyo Univ, Sch Med, Dept Biochem, Tokyo 1738605, Japan.
EM maeba@med.teikyo-u.ac.jp
RI HARA, HIROSHI/A-4581-2012; Sakurai, Toshihiro/K-9109-2019
OI Sakurai, Toshihiro/0000-0003-1759-3802
FU "Knowledge Cluster Initiative" (second stage, "Sapporo Biocluster
   Bio-S") of the Ministry of Education, Science, Sports and Culture of
   Japan
FX This study was supported by the "Knowledge Cluster Initiative" (second
   stage, "Sapporo Biocluster Bio-S") of the Ministry of Education,
   Science, Sports and Culture of Japan. The authors report no financial
   conflicts of interest.
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NR 45
TC 39
Z9 40
U1 0
U2 5
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0022-2275
EI 1539-7262
J9 J LIPID RES
JI J. Lipid Res.
PD MAY
PY 2014
VL 55
IS 5
BP 956
EP 965
DI 10.1194/jlr.P045591
PG 10
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA AG3QR
UT WOS:000335335100019
PM 24616482
OA Green Published, Green Accepted, hybrid
DA 2025-06-11
ER

PT J
AU Cetinkalp, S
   Simsir, IY
   Ertek, S
AF Cetinkalp, Sevki
   Simsir, Ilgin Y.
   Ertek, Sibel
TI Insulin Resistance in Brain and Possible Therapeutic Approaches
SO CURRENT VASCULAR PHARMACOLOGY
LA English
DT Article
DE Brain; hypothalamus; insulin resistance; leptin
ID MILD COGNITIVE IMPAIRMENT; CENTRAL-NERVOUS-SYSTEM; ALZHEIMERS-DISEASE;
   BODY-WEIGHT; METABOLIC SYNDROME; LEPTIN RESISTANCE; RAT-BRAIN;
   GENE-EXPRESSION; MESSENGER-RNA; BETA-CELLS
AB Although the brain has long been considered an insulin-independent organ, recent research has shown that insulin has significant effects on the brain, where it plays a role in maintaining glucose and energy homeostasis. To avoid peripheral insulin resistance, the brain may act via hypoinsulinemic responses, maintaining glucose metabolism and insulin sensitivity within its own confines; however, brain insulin resistance may develop due to environmental factors. Insulin has two important functions in the brain: controlling food intake and regulating cognitive functions, particularly memory. Notably, defects in insulin signaling in the brain may contribute to neurodegenerative disorders. Insulin resistance may damage the cognitive system and lead to dementia states. Furthermore, inflammatory processes in the hypothalamus, where insulin receptors are expressed at high density, impair local signaling systems and cause glucose and energy metabolism disorders. Excessive caloric intake and high-fat diets initiate insulin and leptin resistance by inducing mitochondrial dysfunction and endoplasmic reticulum stress in the hypothalamus. This may lead to obesity and diabetes mellitus (DM). Exercise can enhance brain and hypothalamic insulin sensitivity, but it is the option least preferred and/or continuously practiced by the general population. Pharmacological treatments that increase brain and hypothalamic insulin sensitivity may provide new insights into the prevention of dementia disorders, obesity, and type 2 DM in the future.
C1 [Cetinkalp, Sevki; Simsir, Ilgin Y.] Ege Univ, Sch Med, Dept Endocrinol & Metab Dis, TR-35100 Izmir, Turkey.
   [Ertek, Sibel] Sanliurfa Training & Res Hosp, Turkish Minist Hlth, Dept Endocrinol & Metab Dis, Sanliurfa, Turkey.
C3 Ege University; Sanliurfa Training & Research Hospital; Ministry of
   Health - Turkey
RP Cetinkalp, S (corresponding author), Ege Univ, Sch Med, Dept Endocrinol & Metab Dis, TR-35100 Izmir, Turkey.
EM scetinkalp@hotmail.com
RI Ertek, Sibel/V-1593-2018; SIMSIR, ILGIN/A-4277-2018
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NR 120
TC 38
Z9 43
U1 0
U2 19
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1570-1611
EI 1875-6212
J9 CURR VASC PHARMACOL
JI Current Vascular Pharmacology
PY 2014
VL 12
IS 4
BP 553
EP 564
DI 10.2174/1570161112999140206130426
PG 12
WC Pharmacology & Pharmacy; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Cardiovascular System & Cardiology
GA AW4US
UT WOS:000346276400002
PM 23627981
DA 2025-06-11
ER

PT J
AU Favero, G
   Rezzani, R
   Rodella, LF
AF Favero, Gaia
   Rezzani, Rita
   Rodella, Luigi Fabrizio
TI Sirtuin 6 nuclear localization at cortical brain level of young diabetic
   mice: An immunohistochemical study
SO ACTA HISTOCHEMICA
LA English
DT Article
DE Type II Diabetes mellitus; Sirtuin 6; Brain cortex;
   Immunohistochemistry; Mice
ID HIGH-FAT DIET; METABOLIC SYNDROME; OXIDATIVE STRESS; EMERGING ROLES;
   DISEASES
AB A study was conducted to assess the physiopathological significance of sirtuin 6 (SIRT6) at the brain cortical level. We analyzed the specific expression and subcellular localization of SIRT6 in young db/db mice, an experimental animal model of type II Diabetes mellitus. We analyzed the cytoarchitecture of the brain cortex, evaluated SIRT6 expression and its localization by immunohistochemistry comparing db/db mice to lean control mice, examining the six cortical layers and the motor and somatosensory cortex. Finally, we calculated a SIRT6 labeling index. We observed the absence of significant morphological differences between lean and db/db mice, indicating that young db/db mice showed a neuronal morphology and distribution similar to that of lean mice and also normal brain tissue architecture with intact cortical layers. Moreover, sirtuin 6 is mainly localized in the nucleus of both lean and db/db mice. In particular, the db/db mice showed few positive cells compared to lean control mice in all cortical layers. We found a lower sirtuin 6 labeling index without significant differences between the motor and somatosensory cortex.
   Our findings contribute to further understanding the sirtuin 6 immunohistochemical changes in the early stages of type II Diabetes mellitus and propose its possible implication in the pathogenic processes associated with Diabetes mellitus and diabetes-induced neurodegeneration. (C) 2013 Elsevier GmbH. All rights reserved.
C1 [Favero, Gaia; Rezzani, Rita; Rodella, Luigi Fabrizio] Univ Brescia, Sect Anat & Physiopathol, Dept Clin & Expt Sci, I-25123 Brescia, Italy.
C3 University of Brescia
RP Rodella, LF (corresponding author), Univ Brescia, Sect Anat & Physiopathol, Dept Clin & Expt Sci, Viale Europa 11, I-25123 Brescia, Italy.
EM rodella@med.unibs.it
RI Rodella, Luigi/F-1079-2010
OI Rodella, Luigi Fabrizio/0000-0002-9497-4708; Favero,
   Gaia/0000-0001-6895-7106
FU University of Brescia, Italy
FX We extend our sincere thanks to Miss Stefania Castrezzati and Mrs Lorena
   Giugno for their technical support. This study was supported by a grant
   (ex-60%) of the University of Brescia, Italy.
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PU ELSEVIER GMBH
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SN 0065-1281
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J9 ACTA HISTOCHEM
JI Acta Histochem.
PY 2014
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WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
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PM 24063863
DA 2025-06-11
ER

PT J
AU Smith, BW
   Adams, LA
AF Smith, Briohny W.
   Adams, Leon A.
TI Nonalcoholic fatty liver disease and diabetes mellitus: pathogenesis and
   treatment
SO NATURE REVIEWS ENDOCRINOLOGY
LA English
DT Review
ID PLACEBO-CONTROLLED TRIAL; INSULIN-RESISTANCE; HEPATIC STEATOSIS;
   CARDIOVASCULAR-DISEASE; AMINOTRANSFERASE LEVELS; URSODEOXYCHOLIC ACID;
   METABOLIC SYNDROME; NATURAL-HISTORY; ADIPOSE-TISSUE; VISCERAL FAT
AB Nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM) frequently coexist as they share the pathogenic abnormalities of excess adiposity and insulin resistance. Although type 1 diabetes mellitus (T1DM) is due to a relative lack of insulin, an increased prevalence of obesity and insulin resistance in this population means that NAFLD also commonly coexists with this condition. Both T2DM and NAFLD are associated with adverse outcomes of the other; T2DM is a risk factor for progressive liver disease and liver-related death in patients with NAFLD, whereas NAFLD may be a marker of cardiovascular risk and mortality in individuals with T2DM. Nonalcoholic steatohepatitis-a histological subtype of NAFLD characterized by hepatocyte injury and inflammation-is present in approximately 10% of patients with T2DM and is associated with an increased risk for the development of cirrhosis and liver-related death. Current treatment strategies aim to improve insulin resistance via weight loss and exercise, improve insulin sensitivity by the use of insulin-sensitizing agents (for example, pioglitazone) and reduce oxidative stress by the use of antioxidants, such as vitamin E. Pioglitazone and vitamin E supplementation show the most promise in improving hepatic steatosis and inflammation but have not yet been demonstrated to improve fibrosis, and concern remains regarding the toxicity of long-term use of both of these agents.
C1 [Smith, Briohny W.; Adams, Leon A.] Univ Western Australia, Sch Med & Pharmacol, Sir Charles Gairdner Hosp Unit, Nedlands, WA 6009, Australia.
C3 University of Western Australia
RP Adams, LA (corresponding author), Univ Western Australia, Sch Med & Pharmacol, Sir Charles Gairdner Hosp Unit, Verdun St, Nedlands, WA 6009, Australia.
EM leon.adams@uwa.edu.au
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NR 139
TC 264
Z9 293
U1 1
U2 43
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 1759-5029
EI 1759-5037
J9 NAT REV ENDOCRINOL
JI Nat. Rev. Endocrinol.
PD AUG
PY 2011
VL 7
IS 8
BP 456
EP 465
DI 10.1038/nrendo.2011.72
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 796RV
UT WOS:000293070500007
PM 21556019
DA 2025-06-11
ER

PT J
AU Yessoufou, A
   Moutairou, K
AF Yessoufou, Akadiri
   Moutairou, Kabirou
TI Maternal Diabetes in Pregnancy: Early and Long-Term Outcomes on the
   Offspring and the Concept of "Metabolic Memory"
SO EXPERIMENTAL DIABETES RESEARCH
LA English
DT Review
ID POLYUNSATURATED FATTY-ACIDS; NECROSIS-FACTOR-ALPHA; AGE-RELATED-CHANGES;
   OXIDATIVE STRESS; INSULIN-RESISTANCE; WEIGHT-GAIN; ANTIOXIDANT STATUS;
   CYTOKINE PROFILES; GENE-EXPRESSION; BIRTH-WEIGHT
AB The adverse outcomes on the offspring from maternal diabetes in pregnancy are substantially documented. In this paper, we report main knowledge on impacts of maternal diabetes on early and long-term health of the offspring, with specific comments on maternal obesity. The main adverse outcome on progenies from pregnancy complicated with maternal diabetes appears to be macrosomia, as it is commonly known that intrauterine exposure to hyperglycemia increases the risk and programs the offspring to develop diabetes and/or obesity at adulthood. This "fetal programming", due to intrauterine diabetic milieu, is termed as "metabolic memory". In gestational diabetes as well as in macrosomia, the complications include metabolic abnormalities, degraded antioxidant status, disrupted immune system and potential metabolic syndrome in adult offspring. Furthermore, there is evidence that maternal obesity may also increase the risk of obesity and diabetes in offspring. However, women with GDM possibly exhibit greater macrosomia than obese women. Obesity and diabetes in pregnancy have independent and additive effects on obstetric complications, and both require proper management. Management of gestational diabetes mellitus and maternal obesity is essential for maternal and offspring's good health. Increasing physical activity, preventing gestational weight gain, and having some qualitative nutritional habits may be beneficial during both the pregnancy and offspring's future life.
C1 [Yessoufou, Akadiri] Univ Lausanne, Ctr Integrat Genom, CH-1015 Lausanne, Switzerland.
   [Yessoufou, Akadiri; Moutairou, Kabirou] Univ Abomey Calavi, Lab Cell Biol & Physiol, Dept Biochem & Cellular Biol, Fac Sci & Tech, Cotonou, Benin.
   [Yessoufou, Akadiri; Moutairou, Kabirou] Univ Abomey Calavi, ISBA, Cotonou, Benin.
C3 University of Lausanne; University of Abomey Calavi; University of
   Abomey Calavi
RP Yessoufou, A (corresponding author), Univ Lausanne, Ctr Integrat Genom, Genopode Bldg,5E Etage, CH-1015 Lausanne, Switzerland.
EM yeskad2001@yahoo.fr
FU French Foreign Office; Ministry of Higher Education and Research
   (France); Islamic Development Bank (IDB); Office of Scholarship
   Programme
FX The work performed in the authors' laboratory was supported by the
   French Foreign Office and the Ministry of Higher Education and Research
   (France) which sanctioned the contingent grants for the work. The
   authors also express our sincere thanks to the Islamic Development Bank
   (IDB) and the Office of Scholarship Programme that granted a
   postdoctoral fellowship to A. Yessoufou at the Centre for Integrative
   Genomics (University of Lausanne, Switzerland). Their thanks also go to
   Dr. Rousseau F. Djouaka (The International Institute for Tropical
   Agriculture, Ibadan, Nigeria, and Collaborator of the Liverpool School
   of Tropical Medicine, UK) for checking the English style and for his
   valuable linguistic advice.
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NR 108
TC 190
Z9 212
U1 0
U2 16
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1687-5214
EI 1687-5303
J9 EXP DIABETES RES
JI Exp. Diabetes Res.
PY 2011
AR 218598
DI 10.1155/2011/218598
PG 12
WC Endocrinology & Metabolism; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Research & Experimental Medicine
GA 870OP
UT WOS:000298679100001
PM 22144985
OA Green Published, Green Submitted, hybrid
DA 2025-06-11
ER

PT J
AU Navarro-Ledesma, S
AF Navarro-Ledesma, Santiago
TI Frozen Shoulder as a Metabolic and Immune Disorder: Potential Roles of
   Leptin Resistance, JAK-STAT Dysregulation, and Fibrosis
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Review
DE frozen shoulder; metabolism; immunology; psychology; rehabilitation
ID PROPIONIBACTERIUM-ACNES; ENERGY HOMEOSTASIS; GUT MICROBIOTA; OBESITY;
   INFLAMMATION; PATHWAY; RECEPTOR; OUTCOMES; TARGET; JOINT
AB Frozen shoulder (FS) is a complex and multifactorial condition characterized by persistent inflammation, fibrosis, and metabolic dysregulation. Despite extensive research, the underlying drivers of FS remain poorly understood. Recent findings indicate the coexistence of pro-inflammatory and fibrosis-resolving macrophages within affected tissues, suggesting a dysregulated immune response influenced by metabolic and neuroendocrine factors. This review proposes that leptin resistance, a hallmark of metabolic syndrome and chronic inflammation, may play a central role in FS pathogenesis by impairing macrophage polarization, perpetuating inflammation, and disrupting fibrosis resolution. The JAK-STAT signaling pathway, critically modulated by leptin resistance, may further contribute to immune dysregulation by sustaining inflammatory macrophage activation and interfering with tissue remodeling. Additionally, FS shares pathogenic features with fibrotic diseases driven by TGF-beta signaling, mitochondrial dysfunction, and circadian disruption, further linking systemic metabolic dysfunction to localized fibrotic pathology. Beyond immune and metabolic regulation, alterations in gut microbiota, bacterial translocation, and chronic psychosocial stress may further exacerbate systemic inflammation and neuroendocrine imbalances, intensifying JAK-STAT dysregulation and leptin resistance. By examining the intricate interplay between metabolism, immune function, and fibrotic remodeling, this review highlights targeting leptin sensitivity, JAK-STAT modulation, and mitochondrial restoration as novel therapeutic strategies for FS treatment. Future research should explore these interconnections to develop integrative interventions that address both the metabolic and immune dysregulation underlying FS, ultimately improving clinical outcomes.
C1 [Navarro-Ledesma, Santiago] Univ Granada, Fac Hlth Sci, Dept Physiotherapy, Campus Melilla, Querol St 5, Melilla 52004, Spain.
C3 University of Granada
RP Navarro-Ledesma, S (corresponding author), Univ Granada, Fac Hlth Sci, Dept Physiotherapy, Campus Melilla, Querol St 5, Melilla 52004, Spain.
EM snl@ugr.es
RI Navarro-Ledesma, Santiago/K-5660-2017
OI Navarro-Ledesma, Santiago/0000-0002-4302-1106
FU Autonomous City of Melilla [MEL-02-UGR24]
FX This publication is part of the project Ref. No.: MEL-02-UGR24, funded
   by the Autonomous City of Melilla as part of its commitment to research.
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NR 129
TC 1
Z9 1
U1 3
U2 3
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD MAR
PY 2025
VL 14
IS 5
AR 1780
DI 10.3390/jcm14051780
PG 19
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 0EA2O
UT WOS:001445131100001
PM 40095902
OA gold
DA 2025-06-11
ER

PT J
AU Mouskeftara, T
   Kalopitas, G
   Liapikos, T
   Arvanitakis, K
   Germanidis, G
   Gika, H
AF Mouskeftara, Thomai
   Kalopitas, Georgios
   Liapikos, Theodoros
   Arvanitakis, Konstantinos
   Germanidis, Georgios
   Gika, Helen
TI Predicting Non-Alcoholic Steatohepatitis: A Lipidomics-Driven Machine
   Learning Approach
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE untargeted lipidomics; non-alcoholic fatty liver disease; plasma;
   machine learning
ID FATTY-LIVER-DISEASE; NAFLD FIBROSIS SCORE; METABOLIC SYNDROME;
   PROGRESSION; BIOMARKERS; NUTRITION
AB Nonalcoholic fatty liver disease (NAFLD), nowadays the most prevalent chronic liver disease in Western countries, is characterized by a variable phenotype ranging from steatosis to nonalcoholic steatohepatitis (NASH). Intracellular lipid accumulation is considered the hallmark of NAFLD and is associated with lipotoxicity and inflammation, as well as increased oxidative stress levels. In this study, a lipidomic approach was used to investigate the plasma lipidome of 12 NASH patients, 10 Nonalcoholic Fatty Liver (NAFL) patients, and 15 healthy controls, revealing significant alterations in lipid classes, such as glycerolipids and glycerophospholipids, as well as fatty acid compositions in the context of steatosis and steatohepatitis. A machine learning XGBoost algorithm identified a panel of 15 plasma biomarkers, including HOMA-IR, BMI, platelets count, LDL-c, ferritin, AST, FA 12:0, FA 18:3 omega 3, FA 20:4 omega 6/FA 20:5 omega 3, CAR 4:0, LPC 20:4, LPC O-16:1, LPE 18:0, DG 18:1_18:2, and CE 20:4 for predicting steatohepatitis. This research offers insights into the connection between imbalanced lipid metabolism and the formation and progression of NAFL D, while also supporting previous research findings. Future studies on lipid metabolism could lead to new therapeutic approaches and enhanced risk assessment methods, as the shift from isolated steatosis to NASH is currently poorly understood.
C1 [Mouskeftara, Thomai; Gika, Helen] Aristotle Univ Thessaloniki, Fac Hlth Sci, Sch Med, Lab Forens Med & Toxicol, Thessaloniki 54124, Greece.
   [Mouskeftara, Thomai; Gika, Helen] Ctr Interdisciplinary Res & Innovat CIRI AUTH, Balkan Ctr B1 4, Bi AUTh, 10th Km Thessaloniki Thermi Rd, Thessaloniki 57001, Greece.
   [Kalopitas, Georgios; Germanidis, Georgios] Aristotle Univ Thessaloniki, AHEPA Univ Hosp, Dept Internal Med 1, Div Gastroenterol & Hepatol,Sch Med,Fac Hlth Sci, Thessaloniki 54636, Greece.
   [Kalopitas, Georgios; Germanidis, Georgios] Aristotle Univ Thessaloniki, Sch Med, Basic & Translat Res Unit, Special Unit Biomed Res & Educ,Fac Hlth Sci, Thessaloniki 54636, Greece.
   [Kalopitas, Georgios; Germanidis, Georgios] Aristotle Univ Thessaloniki, Fac Hlth Sci, Sch Med, Lab Hyg Social & Prevent Med & Med Stat, Thessaloniki 54636, Greece.
   [Liapikos, Theodoros] Aristotle Univ Thessaloniki, Dept Chem, Lab Analyt Chem, Thessaloniki 54124, Greece.
   [Arvanitakis, Konstantinos] Aristotle Univ Thessaloniki, AHEPA Univ Hosp, Dept Internal Med 1, Thessaloniki 54636, Greece.
C3 Aristotle University of Thessaloniki; Aristotle University of
   Thessaloniki; Ahepa University Hospital; Aristotle University of
   Thessaloniki; Aristotle University of Thessaloniki; Aristotle University
   of Thessaloniki; Aristotle University of Thessaloniki; Ahepa University
   Hospital
RP Gika, H (corresponding author), Aristotle Univ Thessaloniki, Fac Hlth Sci, Sch Med, Lab Forens Med & Toxicol, Thessaloniki 54124, Greece.; Gika, H (corresponding author), Ctr Interdisciplinary Res & Innovat CIRI AUTH, Balkan Ctr B1 4, Bi AUTh, 10th Km Thessaloniki Thermi Rd, Thessaloniki 57001, Greece.
EM mousthom@auth.gr; gekalopi@auth.gr; theoliapikos@gmail.com;
   arvanitak@auth.gr; geogerm@auth.gr; gkikae@auth.gr
RI Gika, Helen/I-3638-2012; Kalopitas, Georgios/HPC-2449-2023; GERMANIDIS,
   GEORGIOS/ABI-3764-2020; ARVANITAKIS, KONSTANTINOS/AAR-8172-2021
OI MOUSKEFTARA, THOMAI/0000-0003-2511-1236; Gika,
   Helen/0000-0002-1893-937X; ARVANITAKIS,
   KONSTANTINOS/0000-0002-3574-8209; Liapikos,
   Theodore/0000-0002-5311-5384; Kalopitas, Georgios/0000-0002-4962-790X;
   GERMANIDIS, GEORGIOS/0000-0001-7985-3118
FU BiACEM, Biomic_AUTh, Center of Excellence in Metabolomics research
   [101079370]; Horizon Europe - Horizontal Pillar [101079370] Funding
   Source: Horizon Europe - Horizontal Pillar
FX The work has been done with the support of BiACEM, Biomic_AUTh, Center
   of Excellence in Metabolomics research under the
   HORIZON-WIDERA-2021-ACCESS-03-01 Twinning, Project 101079370.
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NR 61
TC 7
Z9 7
U1 4
U2 4
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD JUN
PY 2024
VL 25
IS 11
AR 5965
DI 10.3390/ijms25115965
PG 17
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA UB7O1
UT WOS:001245668900001
PM 38892150
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Choudhary, R
   Singh, A
   Upadhyay, A
   Singh, R
   Thangalakshmi, S
   Dar, AH
   Bajpai, VK
   Shukla, S
AF Choudhary, Rita
   Singh, Anurag
   Upadhyay, Ashutosh
   Singh, Rakhi
   Thangalakshmi, S.
   Dar, Aamir H.
   Bajpai, Vivek K.
   Shukla, Shruti
TI Exotic god fruit, persimmon (Diospyros kaki): Pharmacological
   importance and human health aspects
SO EFOOD
LA English
DT Review
DE antioxidant; human health; persimmon; pharmacological importance
ID BLOOD-PRESSURE; GREEN TEA; ANTIOXIDANT ACTIVITY; OXIDATIVE STRESS;
   INSULIN SENSITIVITY; BIOACTIVE COMPOUNDS; DIETARY FLAVONOIDS; METABOLIC
   SYNDROME; TROPICAL FRUITS; DARK CHOCOLATE
AB The persimmon fruit (Diospyros kaki) belonging to the family Ebenaceae, is a famous conventional Korean medicinal herb. Calyx of persimmon has been used to prepare herbal drinks in Korea, China, and Japan due to its various functional ingredients, including fructose, glucose, and triterpenoid. In addition, persimmon is generally used as traditional medicine in Korea for the treatment of asthma, chronic bronchitis, and cough. Various useful constituents have been isolated and characterized from Diospyros species, including naphthaquinones, triterpenoids, and steroids. The fruit's nutritional composition comprising 80.3% water, 0.58% protein, 0.19% total lipids, 18.6% total carbohydrates and some minerals, and up to 1.48 g and 7.5 mg total dietary fiber, and ascorbic acid, respectively. Specifically, a flavonoid, fisetin, present in persimmon is associated with killing breast cancer cells without harming normal breast cells, thus contributing to the programmed eradication of colon and prostate cancer cells. Some other notable compounds reported from the various parts of the plant and their extracts have significant pharmaceutical values due to their antioxidant, anticancer, anti-aging, and cytotoxic activities. It is, therefore, high time to promote the consumption of exotic fruits with a rich source of natural antioxidants as a functional supplement to the human diet, with a view to increase the disease protection efficacy.
C1 [Choudhary, Rita; Shukla, Shruti] TERI Deakin Nanobiotechnol Ctr, Energy & Resources Inst, Div Sustainable Agr, Gurugram 122003, Haryana, India.
   [Singh, Anurag; Upadhyay, Ashutosh; Singh, Rakhi] Natl Inst Food Technol Entrepreneurship & Manageme, Dept Food Sci & Technol, Sonipat, Haryana, India.
   [Thangalakshmi, S.] Natl Inst Food Technol Entrepreneurship & Manageme, Dept Food Engn, Sonipat, Haryana, India.
   [Dar, Aamir H.] Islamic Univ Sci & Technol, Dept Food Technol, Awantipora 192122, Kashmir, India.
   [Bajpai, Vivek K.] Dongguk Univ, Dept Energy & Mat Engn, Seoul 04620, South Korea.
C3 Dongguk University
RP Shukla, S (corresponding author), TERI Deakin Nanobiotechnol Ctr, Energy & Resources Inst, Div Sustainable Agr, Gurugram 122003, Haryana, India.; Bajpai, VK (corresponding author), Dongguk Univ, Dept Energy & Mat Engn, Seoul 04620, South Korea.
EM vbiotech04@gmail.com; shruti.shukla@teri.res.in
RI Shukla, Shruti/HOA-8954-2023; upadhyay, ashutosh/ABI-3685-2020; Dar,
   Aamir/ABG-7200-2020; SINGH, ANURAG/AAA-1899-2022
OI shukla, shruti/0000-0002-1315-0759; SINGH, ANURAG/0000-0003-2844-9144
FU TERI, New Delhi, India and Department of Biotechnology (DBT) -
   Ramalingaswamy Fellowship Grant; TERI, New Delhi, India
   [BT/RLF/Re-entry/20/2017]; Department of Biotechnology (DBT) -
   Ramalingaswamy Fellowship Grant
FX The authors would like to thank to TERI, New Delhi, India and Department
   of Biotechnology (DBT) - Ramalingaswamy Fellowship Grant
   (BT/RLF/Re-entry/20/2017), Government of India for providing all
   research supports.
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NR 124
TC 10
Z9 10
U1 1
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
EI 2666-3066
J9 EFOOD
JI eFood
PD FEB
PY 2023
VL 4
IS 1
AR e52
DI 10.1002/efd2.52
PG 13
WC Food Science & Technology
WE Emerging Sources Citation Index (ESCI)
SC Food Science & Technology
GA EC3L1
UT WOS:001136673500001
OA gold
DA 2025-06-11
ER

PT J
AU Gouda, K
   AbdelHamid, S
   Mansour, A
   Omar, N
   El-Mesallamy, H
AF Gouda, Khaled
   AbdelHamid, Sherihan
   Mansour, Ahmed
   Omar, Nesreen
   El-Mesallamy, Hala
TI Amelioration of Diabetic Nephropathy by Targeting Autophagy via
   Rapamycin or Fasting: Relation to Cell Apoptosis/Survival
SO CURRENT ISSUES IN MOLECULAR BIOLOGY
LA English
DT Article
DE autophagy; beta-cell; P-glycoprotein; apoptosis; DM; STZ; fasting;
   rapamycin; mTOR
ID P-GLYCOPROTEIN; BETA-CELL; METABOLIC SYNDROME; JOINT PUBLICATION;
   REVISED GUIDES; DRUG; MECHANISMS; PROTEINS; MTOR; EXPRESSION
AB Autophagy has been demonstrated to have a beneficial effect on diabetic nephropathy (DN). Rapamycin, an inhibitor of mTOR, was shown to stimulate beta-cell autophagy. However, its effects on preventing or ameliorating DN is unclear, and its effects are worth studying. As fasting is now an attractive protective strategy, we aim to compare its effect to rapamycin effects on pancreatic and renal cells. Twenty-eight adult male Wistar Albino rats were randomly divided into four groups, using streptozotocin (STZ) to induce diabetes mellitus (DM). Autophagy was induced by two ways; rapamycin or fasting. The extent of autophagy and apoptosis were investigated by measuring the level of LC3B and p53 proteins, respectively, in pancreatic and kidney tissues using Western blotting (WB) technique and imaging the renal cells under transmission electron microscope. The efflux transporter P-glycoprotein was quantified by WB as well. Rapamycin-induced autophagy occurred concurrently with apoptosis. On the other hand, fasting supported P-glycoprotein recovery and renal cell survival together with disabling beta-cells apoptosis. In conclusion, this study provides a potential link between rapamycin or fasting for the cross-regulation of apoptosis and autophagy in the setting of cell stress as DN. Unlike rapamycin, fasting enhanced the active expression of ABCB1 efflux protein, providing insights on the potential ameliorative effects of fasting in DN that require further elucidation.
C1 [Gouda, Khaled; Omar, Nesreen] Modern Univ Technol & Informat, Fac Pharm, Biochem Dept, Cairo 12055, Egypt.
   [AbdelHamid, Sherihan; El-Mesallamy, Hala] Ain Shams Univ, Fac Pharm, Biochem Dept, Cairo 11566, Egypt.
   [Mansour, Ahmed] Ain Shams Univ, Fac Pharm, Pharmacol & Toxicol Dept, Cairo 11651, Egypt.
   [El-Mesallamy, Hala] Sinai Univ, Dean Fac Pharm, N Sinai 45518, Egypt.
C3 Egyptian Knowledge Bank (EKB); Ain Shams University; Egyptian Knowledge
   Bank (EKB); Ain Shams University; Egyptian Knowledge Bank (EKB); Sinai
   University
RP El-Mesallamy, H (corresponding author), Ain Shams Univ, Fac Pharm, Biochem Dept, Cairo 11566, Egypt.; El-Mesallamy, H (corresponding author), Sinai Univ, Dean Fac Pharm, N Sinai 45518, Egypt.
EM K_Goudaph@hotmail.com; dr.sherehan@pharma.asu.edu.eg;
   dr.ahmedmmansour@yahoo.com; dr.n.nabil@gmail.com;
   Hala.elmosalamy@su.edu.eg
OI El Mesallamy, Hala/0000-0001-8190-536X; AbdelHamid,
   Sherihan/0000-0003-4900-3715
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NR 66
TC 5
Z9 6
U1 1
U2 5
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1467-3037
EI 1467-3045
J9 CURR ISSUES MOL BIOL
JI Curr. Issues Mol. Biol.
PD DEC
PY 2021
VL 43
IS 3
BP 1698
EP 1714
DI 10.3390/cimb43030120
PG 17
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA XX5NS
UT WOS:000736342700001
PM 34698133
OA gold, Green Published
DA 2025-06-11
ER

PT S
AU Kulkarni, P
   Martson, A
   Vidya, R
   Chitnavis, S
   Harsulkar, A
AF Kulkarni, Priya
   Martson, Aare
   Vidya, Ragini
   Chitnavis, Shreya
   Harsulkar, Abhay
BE Makowski, GS
TI Pathophysiological landscape of osteoarthritis
SO ADVANCES IN CLINICAL CHEMISTRY, VOL 100
SE Advances in Clinical Chemistry
LA English
DT Review; Book Chapter
ID NF-KAPPA-B; HUMAN ARTICULAR CHONDROCYTES; NITRIC-OXIDE SYNTHASE;
   GROWTH-FACTOR REGULATION; KNEE OSTEOARTHRITIS; SYNOVIAL-FLUID;
   RHEUMATOID-ARTHRITIS; T-CELLS; GENE-EXPRESSION; MATRIX-METALLOPROTEINASE
AB A sharp rise in osteoarthritis (OA) incidence is expected as over 25% of world population ages in the coming decade. Although OA is considered a degenerative disease, mounting evidence suggests a strong connection with chronic metabolic conditions and low-grade inflammation. OA pathology is increasingly understood as a complex interplay of multiple pathological events including oxidative stress, synovitis and immune responses revealing its intricate nature. Cellular, biochemical and molecular aspects of these pathological events along with major outcomes of the relevant research studies in this area are discussed in the present review. With reference to their published and unpublished work, the authors strongly propose synovitis as a central OA pathology and the key OA pathological events are described in connection with it. Recent research outcomes also have succeeded to establish a linkage between metabolic syndrome and OA, which has been precisely included in the present review. Impact of aging process cannot be neglected in OA. Cell senescence is an important mechanism of aging through which it facilitates development of OA like other degenerative disorders, also discussed within a frame of OA. Conclusively, the reviewers urge low-grade inflammation linked to aging and derailed immune function as a pathological platform for OA development and progression. Thus, interventions targeted to prevent inflammaging hold a promising potential in effective OA management and efforts should be invested in this direction.
C1 [Kulkarni, Priya; Harsulkar, Abhay] Univ Tartu, Dept Pathophysiol Biomed & Translat Med, Tartu, Estonia.
   [Kulkarni, Priya; Martson, Aare] Tartu Univ Hosp, Dept Traumatol & Orthopaed, Tartu, Estonia.
   [Martson, Aare] Tartu Univ Hosp, Clin Traumatol & Orthopaed, Tartu, Estonia.
   [Vidya, Ragini; Chitnavis, Shreya; Harsulkar, Abhay] Poona Coll Pharm, Dept Pharmaceut Biotechnol, Pune, Maharashtra, India.
C3 University of Tartu; Bharati Vidyapeeth Deemed University; Poona College
   of Pharmacy
RP Harsulkar, A (corresponding author), Univ Tartu, Dept Pathophysiol Biomed & Translat Med, Tartu, Estonia.; Harsulkar, A (corresponding author), Poona Coll Pharm, Dept Pharmaceut Biotechnol, Pune, Maharashtra, India.
EM aharsulkar@yahoo.com
RI Kulkarni, Priya/KFQ-8755-2024; Harsulkar, Abhay/IAO-6728-2023; Martson,
   Aare/AAQ-8714-2020
OI KULKARNI, PRIYA/0000-0001-8331-8740
FU INNO-INDIGO; Dora Plus programme; Archimedes Foundation, Estonia
   Government
FX Authors acknowledge INNO-INDIGO, funding scheme for Indo-European
   cooperation projects in the field of research and innovation, for their
   financial support in the present work. We thank Dora Plus programme and
   Archimedes Foundation, Estonia Government for providing travel grants to
   P.K. and A.H., respectively, for the research studies included in this
   review. We acknowledge Professor Suresh Dhaigude, M.A., PhD (English),
   former Professor at Department of English, Pune University for his
   efforts to improve grammar, clarity and readability of the text. Authors
   also thank Dr. Shantanu Deshapande, Associate Professor and Orthopedic
   Surgeon, Bharati Vidyapeeth Medical College, Bharati Vidyapeeth
   University, Pune for sharing pictures of arthroscopic view of human
   cartilage.
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NR 239
TC 65
Z9 68
U1 2
U2 28
PU ACADEMIC PRESS LTD-ELSEVIER SCIENCE LTD
PI LONDON
PA 125 LONDON WALL, LONDON EC2Y 5AS, ENGLAND
SN 0065-2423
EI 2162-9471
BN 978-0-12-823922-3
J9 ADV CLIN CHEM
JI Advan. Clin. Chem.
PY 2021
VL 100
BP 37
EP 90
DI 10.1016/bs.acc.2020.04.002
PG 54
WC Medical Laboratory Technology
WE Book Citation Index – Science (BKCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA BQ5XL
UT WOS:000609202400003
PM 33453867
DA 2025-06-11
ER

PT J
AU El-Boghdady, NA
   Kamel, MA
   El-Shamy, RM
AF El-Boghdady, Noha A.
   Kamel, Maher A.
   El-Shamy, Rouaina M.
TI Omeprazole and Spirulina Platensis Ameliorate Steatohepatitis in
   Experimental Nonalcoholic Fatty Liver Disease
SO METABOLIC SYNDROME AND RELATED DISORDERS
LA English
DT Article
DE nonalcoholic fatty liver disease; Spirulina Platensis; omeprazole;
   hepatocyte apoptosis; metabolic syndrome; inflammation; oxidative stress
ID DENSITY-LIPOPROTEIN CHOLESTEROL; ANIMAL-MODELS; APOPTOSIS; EXTRACT;
   MECHANISMS; EXPRESSION; STEATOSIS; CYTOKINES; EXERCISE; PLASMA
AB Background:Nonalcoholic fatty liver disease (NAFLD) is a leading cause of liver damage, and it affects about 24% of the population worldwide. This study aimed to investigate the effect of omeprazole and Spirulina platensis on hepatic and serum biochemical alterations in NAFLD induced by high-fat diet (HFD). Methods:Male Wistar rats were divided into four groups; one served as a normal control. The other groups received HFD and subdivided into three subgroups; one was left untreated and the other two groups were treated orally with either omeprazole (10 mg/kg) or Spirulina (1000 mg/kg) for 30 consecutive days. Results:Omeprazole successfully decreased elevated serum pentraxin-3 (PTX-3) and cytokeratin-18 (CK-18) levels and hepatic sterol regulatory element binding protein-1c (SREBP-1c) expression, while Spirulina had better impact on decreasing liver function enzymes, lipid profile, and nuclear factor erythroid 2-related factor 2 (Nrf-2) levels compared to omeprazole. Both treatments had similar effects on normalizing glucose homeostasis, decreasing insulin resistance, and improving adipocytokine levels. Conclusion:Effects of omeprazole and Spirulina on markers of NAFLD appeared to be mediated by regulation of inflammatory, apoptotic, and oxidative mediators. Thus, omeprazole and Spirulina may find use as promising adjuvant therapy to ameliorate NAFLD. Research ethical committee of the faculty of pharmacy, Cairo University approved the research (BC 1479).
C1 [El-Boghdady, Noha A.; El-Shamy, Rouaina M.] Cairo Univ, Biochem Dept, Fac Pharm, Cairo 11562, Egypt.
   [Kamel, Maher A.] Alexandria Univ, Med Res Inst, Biochem Dept, Alexandria, Egypt.
C3 Egyptian Knowledge Bank (EKB); Cairo University; Egyptian Knowledge Bank
   (EKB); Alexandria University
RP El-Boghdady, NA (corresponding author), Cairo Univ, Biochem Dept, Fac Pharm, Cairo 11562, Egypt.
EM noha.elboghdady@pharma.cu.edu.eg
RI ElShamy, Rouaina/ABA-3790-2020; Kamel, Maher/S-2397-2019
OI Kamel, Maher/0000-0002-6791-9850; El Boghdady, Noha/0000-0002-0173-8125
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NR 57
TC 6
Z9 6
U1 0
U2 7
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-4196
EI 1557-8518
J9 METAB SYNDR RELAT D
JI Metab. Syndr. Relat. Disord.
PD NOV 1
PY 2020
VL 18
IS 9
BP 426
EP 434
DI 10.1089/met.2019.0129
EA AUG 2020
PG 9
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA OJ1HU
UT WOS:000561440600001
PM 32795119
DA 2025-06-11
ER

PT J
AU Rathwa, N
   Parmar, N
   Palit, SP
   Patel, R
   Ramachandran, AV
   Begum, R
AF Rathwa, Nirali
   Parmar, Nishant
   Palit, Sayantani Pramanik
   Patel, Roma
   Ramachandran, A., V
   Begum, Rasheedunnisa
TI Intron specific polymorphic site of vaspin gene along with vaspin
   circulatory levels can influence pathophysiology of type 2 diabetes
SO LIFE SCIENCES
LA English
DT Article
DE Obesity; Dyslipidemia; Single nucleotide polymorphism;
   Genotype-phenotype correlation; Haplotype; Adipokine
ID METABOLIC SYNDROME; INSULIN SENSITIVITY; CHEMERIN RS17173608; CLOCK
   GENES; ASSOCIATION; VARIANTS; RESISTANCE; DISEASE; OBESITY; STRESS
AB Vaspin, an insulin-sensitizing adipokine, has been associated with type 2 diabetes (T2D). The present study aimed to investigate the distribution of genotypes and high-risk alleles of vaspin genetic variants (rs77060950 G/T and rs2236242 A/T), in Gujarat subpopulation (India). Genomic DNA isolated from PBMCs was used to genotype vaspin polymorphisms by PCR-RFLP and ARMS-PCR from 502 controls and 478 patients. RNA isolated from visceral adipose tissue (VAT) of 22 controls and 20 patients was used to assess vaspin transcript levels by qPCR while the vaspin titre of the subjects was assayed using ELISA. Phenotypic characteristics of Fasting Blood Glucose (FBG), BMI and plasma lipid profile were estimated and analyzed for the genotype-phenotype correlation. We identified a significant association of rs2236242 A/T with T2D as the TT genotype conferred a 3.087-fold increased risk. The TT genotype showed association with increased FBG, BMI and Triglycerides levels. Increased GA, GT and TA haplotype frequencies, decreased VAT transcript and vaspin protein levels in T2D patients was observed, which were further negatively correlated with FBG and BMI. In conclusion, rs2274907 A/T polymorphism is strongly associated with reduced vaspin transcript and protein levels, and related metabolic alterations that may play a role in the advancement of T2D.
C1 [Rathwa, Nirali; Parmar, Nishant; Palit, Sayantani Pramanik; Patel, Roma; Begum, Rasheedunnisa] Maharaja Sayajirao Univ Baroda, Fac Sci, Dept Biochem, Vadodara 390002, Gujarat, India.
   [Ramachandran, A., V] Navrachana Univ, Sch Sci, Div Life Sci, Vadodara 391410, Gujarat, India.
C3 Maharaja Sayajirao University Baroda
RP Begum, R (corresponding author), Maharaja Sayajirao Univ Baroda, Fac Sci, Dept Biochem, Vadodara 390002, Gujarat, India.
EM rasheedunnisab@yahoo.co.in
RI Patel, Roma/KVZ-0778-2024; Begum, Rasheedunnisa/AAF-2981-2020
OI Patel, Roma/0000-0002-6037-0498; A. V., Ramachandran/0000-0002-2326-0994
FU Department of Biotechnology, New Delhi, India
   [BT/PR21242/MED/30/1750/2016]
FX This work was supported by the grant to RB (BT/PR21242/MED/30/1750/2016)
   from Department of Biotechnology, New Delhi, India.
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NR 41
TC 6
Z9 6
U1 0
U2 4
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0024-3205
EI 1879-0631
J9 LIFE SCI
JI Life Sci.
PD FEB 15
PY 2020
VL 243
AR 117285
DI 10.1016/j.lfs.2020.117285
PG 6
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA KK8OR
UT WOS:000512996200025
PM 31926241
DA 2025-06-11
ER

PT J
AU Tisato, V
   Romani, A
   Tavanti, E
   Melloni, E
   Milani, D
   Bonaccorsi, G
   Sanz, JM
   Gemmati, D
   Passaro, A
   Cervellati, C
AF Tisato, Veronica
   Romani, Arianna
   Tavanti, Elisa
   Melloni, Elisabetta
   Milani, Daniela
   Bonaccorsi, Gloria
   Sanz, Juana M.
   Gemmati, Donato
   Passaro, Angelina
   Cervellati, Carlo
TI Crosstalk Between Adipokines and Paraoxonase 1: A New Potential Axis
   Linking Oxidative Stress and Inflammation
SO ANTIOXIDANTS
LA English
DT Article
DE oxinflammation; paraoxonase 1 (PON1); adipokines; resistin;
   postmenopausal woman
ID BONE-MINERAL DENSITY; METABOLIC SYNDROME; SERUM PARAOXONASE;
   GENE-EXPRESSION; HDL FUNCTION; PON1; OBESITY; ADIPONECTIN; ARYLESTERASE;
   ASSOCIATION
AB Paraoxonase 1 (PON1) is a high-density lipoprotein (HDL)-associated protein that endows its carrier with (lipo-)lactonase-dependent antioxidative features. Low levels of PON1 activity have been observed in association with obesity, a major risk factor for cardiovascular disease (CVD). Considering the well-recognized atheroprotective role of PON1, exogenous/endogenous factors that might modulate its levels/activity are raising great interest. Since adipokines represent a molecular link between obesity and CVD, we here explored the possible impact of these substances on PON1 activity/expression. The levels of interleukin (IL)-6, IL-8, tumor necrosis factor alpha, monocyte chemoattractant protein-1, hepatocyte growth factor, resistin, leptin, and adiponectin were measured along with arylesterase, paraoxonase, and lactonase activities of PON1 in 107 postmenopausal women. Moreover, the direct effect of resistin on PON1 expression was evaluated in vitro. Multivariate analysis revealed that only resistin was significantly and inversely correlated with PON1-lactonase activities (r = -0.346, p < 0.001) regardless of confounding factors such as age or HDL-cholesterol. It is worth noting that no statistical link was found between adipokine and arylesterase or paraoxonase, the two promiscuous activities of PON1. Notably, resistin down-regulated PON1 expression occurred in hepatocellular carcinoma cultures. Our study suggests that resistin might be a negative modulator of PON1 expression and anti-oxidative activity.
C1 [Tisato, Veronica; Tavanti, Elisa; Milani, Daniela] Univ Ferrara, Dept Morphol Surg & Expt Med, I-44121 Ferrara, Italy.
   [Tisato, Veronica; Tavanti, Elisa; Melloni, Elisabetta; Milani, Daniela] Univ Ferrara, LTTA Ctr, I-44121 Ferrara, Italy.
   [Romani, Arianna; Cervellati, Carlo] Univ Ferrara, Dept Biomed & Specialist Surg Sci, Sect Med Biochem Mol Biol & Genet, I-44121 Ferrara, Italy.
   [Bonaccorsi, Gloria] Univ Ferrara, Menopause & Osteoporosis Ctr, Dept Morphol Surg & Expt Med, I-44121 Ferrara, Italy.
   [Sanz, Juana M.; Passaro, Angelina] Univ Ferrara, Dept Med Sci, Internal Med & CardioResp Sect, I-44121 Ferrara, Italy.
   [Gemmati, Donato] Univ Ferrara, Dept Biomed & Specialist Surg Sci, Sect Med Biochem Mol Biol & Genet, Ctr Hemostasis & Thrombosis, I-44121 Ferrara, Italy.
   [Bonaccorsi, Gloria; Gemmati, Donato] Univ Ferrara, Univ Ctr Studies Gender Med, I-44121 Ferrara, Italy.
C3 University of Ferrara; University of Ferrara; University of Ferrara;
   University of Ferrara; University of Ferrara; University of Ferrara;
   University of Ferrara
RP Tisato, V (corresponding author), Univ Ferrara, Dept Morphol Surg & Expt Med, I-44121 Ferrara, Italy.; Tisato, V (corresponding author), Univ Ferrara, LTTA Ctr, I-44121 Ferrara, Italy.
EM crvcrl@unife.it
RI Sanz, Juana/AAF-7941-2020; Milani, Daniela/N-9560-2014; Tisato,
   Veronica/K-4525-2016; BONACCORSI, GLORIA/AAC-6164-2022; Romani,
   Arianna/AAY-2434-2021; MELLONI, Elisabetta/AAW-7880-2021; Cervellati,
   Carlo/K-6453-2015; Passaro, Angelina/P-3401-2015
OI Romani, Arianna/0000-0001-8000-6178; Gemmati,
   Donato/0000-0001-6213-6120; Sanz Molina, Juana
   Maria/0000-0003-3372-2758; MELLONI, Elisabetta/0000-0002-7829-0824;
   Cervellati, Carlo/0000-0003-4777-6300; Passaro,
   Angelina/0000-0001-8462-7000; Tisato, Veronica/0000-0001-8448-066X
FU "Local Research Project" grant from University of Ferrara, Italy
FX The study was supported by "Local Research Project" grant from
   University of Ferrara, Italy (to C.C.).
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NR 51
TC 19
Z9 19
U1 0
U2 3
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD AUG
PY 2019
VL 8
IS 8
AR 287
DI 10.3390/antiox8080287
PG 11
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA IT6CX
UT WOS:000482958900014
PM 31390816
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Collins, KH
   Herzog, W
   Reimer, RA
   Reno, CR
   Heard, BJ
   Hart, DA
AF Collins, Kelsey H.
   Herzog, Walter
   Reimer, Raylene A.
   Reno, Carol R.
   Heard, Bryan J.
   Hart, David A.
TI Diet-induced obesity leads to pro-inflammatory alterations to the
   vitreous humour of the eye in a rat model
SO INFLAMMATION RESEARCH
LA English
DT Article
DE Obesity; Vitreous humour; NLRP3 inflammasome; Chronic inflammation;
   Antioxidant defense; Rat
ID METABOLIC SYNDROME; IMMUNE-PRIVILEGE; GUT MICROBIOTA; OSTEOARTHRITIS
AB Objective and design The purpose of this study was to investigate if diet-induced obesity (DIO) and subsequent low-level systemic inflammation would result in local increases in pro-inflammatory mediators in the vitreous humour (VH) of the eyes of rats.
   Methods Sixteen male Sprague-Dawley rats were fed a high-fat/high-sucrose (n = 9) or chow control-diet (n = 7) for 12-weeks. RT-qPCR was conducted on RNA from VH cells and a 27-plex-Luminex (R) Assay was conducted on VH fluid and serum.
   Results Increased protein levels for IL-1 beta, IL-6, and IL-18 in both serum and VH fluid were observed. VH protein levels for IL-13 and IL-17 were also increased. All mediators significantly increased in VH fluid were also positively correlated with percent body fat. Increased mRNA levels in VH cells for an oxidative stress molecule were accompanied by decreased mRNA levels for an antioxidant scavenger, suggesting an antioxidant/oxidant imbalance in the VH with DIO. In addition, decreased mRNA levels for TRAIL, FAS-L and TGF-beta, molecules associated with immune privilege, were also significantly depressed.
   Conclusions DIO-related metabolic disturbances disrupt VH homeostasis in a manner that reflects development of a pro-inflammatory environment. Prolonged exposure to such an environment may lead to overt pathologies with compromised eye function.
C1 [Collins, Kelsey H.; Herzog, Walter; Reimer, Raylene A.; Hart, David A.] Univ Calgary, Fac Kinesiol, Human Performance Lab, Calgary, AB, Canada.
   [Collins, Kelsey H.; Herzog, Walter; Reno, Carol R.; Heard, Bryan J.; Hart, David A.] Univ Calgary, McCaig Inst Bone & Joint Hlth, Calgary, AB, Canada.
   [Hart, David A.] Univ British Columbia, Dept Family Practice, Ctr Hip Hlth & Mobil, Vancouver, BC, Canada.
   [Collins, Kelsey H.; Herzog, Walter; Hart, David A.] Univ Calgary, Biomed Engn Program, Calgary, AB, Canada.
   [Reimer, Raylene A.] Univ Calgary, Dept Biochem & Mol Biol, Calgary, AB, Canada.
   [Hart, David A.] Alberta Hlth Serv Bone & Joint Hlth Strateg Clin, Calgary, AB, Canada.
   [Hart, David A.] 3A22 HRIC 3330 Hosp Dr NW, Calgary, AB T2N 4N1, Canada.
C3 University of Calgary; University of Calgary; University of British
   Columbia; University of Calgary; University of Calgary; Alberta Health
   Services (AHS)
RP Hart, DA (corresponding author), Univ Calgary, Fac Kinesiol, Human Performance Lab, Calgary, AB, Canada.; Hart, DA (corresponding author), Univ Calgary, McCaig Inst Bone & Joint Hlth, Calgary, AB, Canada.; Hart, DA (corresponding author), Univ British Columbia, Dept Family Practice, Ctr Hip Hlth & Mobil, Vancouver, BC, Canada.; Hart, DA (corresponding author), Univ Calgary, Biomed Engn Program, Calgary, AB, Canada.; Hart, DA (corresponding author), Alberta Hlth Serv Bone & Joint Hlth Strateg Clin, Calgary, AB, Canada.; Hart, DA (corresponding author), 3A22 HRIC 3330 Hosp Dr NW, Calgary, AB T2N 4N1, Canada.
EM khmcolli@ucalgary.ca; wherzog@ucalgary.ca; reimer@ucalgary.ca;
   hewitt@ucalgary.ca; bjheard@ucalgary.ca; hartd@ucalgary.ca
RI Herzog, Walter/AAG-7188-2020
OI Herzog, Walter/0000-0002-5341-0033; Reimer, Raylene/0000-0001-5088-7947
FU Canadian Institutes of Health Research [RT736475, MOP 115,076]; Canada
   Research Chair Program; Alberta Innovates Health Solutions
   Osteoarthritis Team Grant; Alberta Innovates Health Solutions; Alberta
   Health Services; Canadian Institutes of Health Research Banting and Best
   Canada Graduate Scholarship; Killam Foundation
FX This work was supported by the Canadian Institutes of Health Research #
   RT736475 and MOP 115,076, the Canada Research Chair Program, the Alberta
   Innovates Health Solutions Osteoarthritis Team Grant, Alberta Innovates
   Health Solutions, Alberta Health Services, Canadian Institutes of Health
   Research Banting and Best Canada Graduate Scholarship, and the Killam
   Foundation.
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NR 47
TC 12
Z9 13
U1 0
U2 16
PU SPRINGER BASEL AG
PI BASEL
PA PICASSOPLATZ 4, BASEL, 4052, SWITZERLAND
SN 1023-3830
EI 1420-908X
J9 INFLAMM RES
JI Inflamm. Res.
PD FEB
PY 2018
VL 67
IS 2
BP 139
EP 146
DI 10.1007/s00011-017-1102-y
PG 8
WC Cell Biology; Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Immunology
GA FS6GD
UT WOS:000419895000005
PM 29075814
DA 2025-06-11
ER

PT J
AU Dye, L
   Boyle, NB
   Champ, C
   Lawton, C
AF Dye, Louise
   Boyle, Neil Bernard
   Champ, Claire
   Lawton, Clare
TI The relationship between obesity and cognitive health and decline
SO PROCEEDINGS OF THE NUTRITION SOCIETY
LA English
DT Article; Proceedings Paper
CT Joint Winter Meeting of the Nutrition-Society and the
   Royal-Society-of-Medicine / Conference on Diet, Nutrition and Mental
   Health and Wellbeing / Symposium 1 on Nutrition and Brain Function - How
   Strong is the Evidence?
CY DEC 06-07, 2016
CL Royal Soc Med, London, ENGLAND
SP Nutr Soc
HO Royal Soc Med
DE Obesity; Dementia; Cognitive performance; Cognitive decline
ID BODY-MASS INDEX; IMPAIRED GLUCOSE-TOLERANCE; BRAIN INSULIN-RESISTANCE;
   GLYCEMIC LOAD BREAKFAST; MEDITERRANEAN DIET; ALZHEIMERS-DISEASE;
   RISK-FACTORS; INTRANASAL INSULIN; METABOLIC SYNDROME; DIABETES-MELLITUS
AB The relationship between obesity and cognitive impairment is important given the globally ageing population in whom cognitive decline and neurodegenerative disorders will carry grave individual, societal and financial burdens. This review examines the evidence for the link between obesity and cognitive function in terms of both the immediate effects on cognitive performance, and effects on the trajectory of cognitive ageing and likelihood of dementia. In mid-life, there is a strong association between obesity and impaired cognitive function. Anthropometric measures of obesity are also associated with reduced neural integrity (e.g. grey and white matter atrophy). Increasing age coupled with the negative metabolic consequences of obesity (e.g. type 2 diabetes mellitus) are likely to significantly contribute to cognitive decline and incidence of dementia. Stress is identified as a potential risk factor promoting abdominal obesity and contributing to impaired cognitive function. However, the potentially protective effects of obesity against cognitive decline in older age require further examination. Finally, surgical and whole diet interventions, which address obesity may improve cognitive capacity and confer some protection against later cognitive decline. In conclusion, obesity and its comorbidities are associated with impaired cognitive performance, accelerated cognitive decline and neurodegenerative pathologies such as dementia in later life. Interventions targeting mid-life obesity may prove beneficial in reducing the cognitive risks associated with obesity.
C1 [Dye, Louise; Boyle, Neil Bernard; Champ, Claire; Lawton, Clare] Univ Leeds, Sch Psychol, Leeds Nutr & Behav Grp, Leeds LS2 9JT, W Yorkshire, England.
C3 University of Leeds
RP Boyle, NB (corresponding author), Univ Leeds, Sch Psychol, Leeds Nutr & Behav Grp, Leeds LS2 9JT, W Yorkshire, England.
EM n.b.boyle@leeds.ac.uk
RI Champ, Colin/AAA-6842-2019
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NR 168
TC 298
Z9 321
U1 17
U2 114
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0029-6651
EI 1475-2719
J9 P NUTR SOC
JI Proc. Nutr. Soc.
PD NOV
PY 2017
VL 76
IS 4
BP 443
EP 454
DI 10.1017/S0029665117002014
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI); Conference Proceedings Citation Index - Science (CPCI-S)
SC Nutrition & Dietetics
GA FN6JM
UT WOS:000416120300004
PM 28889822
OA Green Published, Bronze
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Ham, H
   Woo, KS
   Lee, YY
   Lee, B
   Kim, IH
   Lee, J
AF Ham, Hyeonmi
   Woo, Koan Sik
   Lee, Yu Young
   Lee, Byongwon
   Kim, In-Hwan
   Lee, Junsoo
TI Unsaponifiable Matter from Rice Bran Attenuates High Glucose-Induced
   Lipid Accumulation by Activating AMPK in HepG2 Cells
SO JOURNAL OF FOOD BIOCHEMISTRY
LA English
DT Article
ID BINDING PROTEINS SREBPS; ACETYL-COA CARBOXYLASE; METABOLIC SYNDROME;
   TRANSCRIPTION FACTOR; OXIDATIVE STRESS; HEP-G2 CELLS; KINASE;
   CHOLESTEROL; PATHWAY; LIVER
AB Rice bran, a major by-product of rice milling, has a variety of health benefits, including antioxidant, anti-inflammatory, and cholesterol-lowering effects. However, the effects of rice bran unsaponifiable matter (USM) on hepatic lipid metabolism remain unclear. In this study, the effects of rice bran USM in the prevention of high glucose-induced lipid accumulation and its putative mechanism in HepG2 cells were investigated. USM significantly inhibited high glucose-induced lipid accumulation and suppressed fatty acid synthase and sterol regulatory element-binding protein-1c expression in HepG2 cells. It also increased the phosphorylation of AMP-activated protein kinase (AMPK) and acetyl coenzyme A carboxylase. Moreover, a specific inhibitor of AMPK attenuated the effects of USM on lipid accumulation. These results demonstrate that rice bran USM prevents hepatic lipid accumulation via an AMPK-dependent signaling pathway and provides a promising approach for novel lipid-lowering therapies.
   Practical ApplicationRice bran is known to be rich in phytosterols, tocopherols, tocotrienols, and -oryzanol, all of which have health benefits. In recent years, the recognition of the health benefits of rice bran has resulted in its increased use in a range of food products, which far exceeds its usage as a dietary supplement. This study provides biological evidence that supports the use of rice bran unsaponifiable matter in the prevention of hepatic lipid accumulation.
C1 [Ham, Hyeonmi; Woo, Koan Sik; Lee, Yu Young; Lee, Byongwon] Rural Dev Adm, Natl Inst Crop Sci, Dept Cent Area, Suwon 16613, Gyeonggi, South Korea.
   [Kim, In-Hwan] Korea Univ, Dept Food & Nutr, Seoul 02841, South Korea.
   [Lee, Junsoo] Chungbuk Natl Univ, Div Food & Anim Sci, Cheongju 28644, Chungbuk, South Korea.
C3 Rural Development Administration (RDA), Republic of Korea; National
   Institute of Crop Science; Korea University; Chungbuk National
   University
RP Lee, J (corresponding author), Chungbuk Natl Univ, Div Food & Anim Sci, Cheongju 28644, Chungbuk, South Korea.
EM junsoo@chungbuk.ac.kr
RI WOO, KOAN/AAS-8691-2021
FU Rural Development Administration [PJ011037032016]
FX This study was supported by the Rural Development Administration
   (Project number PJ011037032016).
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NR 39
TC 0
Z9 0
U1 0
U2 17
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0145-8884
EI 1745-4514
J9 J FOOD BIOCHEM
JI J. Food Biochem.
PD APR
PY 2017
VL 41
IS 2
AR e12313
DI 10.1111/jfbc.12313
PG 7
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA ES2LD
UT WOS:000399359100019
OA gold
DA 2025-06-11
ER

PT J
AU Wang, HZ
   Jiang, X
   Wu, JY
   Zhang, LQ
   Huang, JF
   Zhang, YR
   Zou, XJ
   Liang, B
AF Wang, Haizhen
   Jiang, Xue
   Wu, Jieyu
   Zhang, Linqiang
   Huang, Jingfei
   Zhang, Yuru
   Zou, Xiaoju
   Liang, Bin
TI Iron Overload Coordinately Promotes Ferritin Expression and Fat
   Accumulation in Caenorhabditis elegans
SO GENETICS
LA English
DT Article
DE iron; serum and glucocorticoid inducible kinase SGK-1; lipid uptake;
   obesity; C. elegans
ID GLUCOCORTICOID-INDUCIBLE KINASE; METABOLIC SYNDROME; SERUM FERRITIN; C.
   ELEGANS; LIFE-SPAN; ADIPOCYTE DIFFERENTIATION; CYTOSOLIC ACONITASE;
   OXIDATIVE STRESS; LIPID-METABOLISM; HUMAN-DISEASE
AB The trace element iron is crucial for living organisms, since it plays essential roles in numerous cellular functions. Systemic iron overload and the elevated level of ferritin, a ubiquitous intracellular protein that stores and releases iron to maintain the iron homeostasis in cells, has long been epidemiologically associated with obesity and obesity-related diseases. However, the underlying mechanisms of this association remain unclear. Here, using Caenorhabditis elegans, we show that iron overload induces the expression of sgk-1, encoding the serum and glucocorticoid-inducible kinase, to promote the level of ferritin and fat accumulation. Mutation of cyp-23A1, encoding a homolog of human cytochrome P450 CYP7B1 that is related to neonatal hemochromatosis, further enhances the elevated expression of ftn-1, sgk-1, and fat accumulation. sgk-1 positively regulates the expression of acs-20 and vit-2, genes encoding homologs of the mammalian FATP1/4 fatty acid transport proteins and yolk lipoproteins, respectively, to facilitate lipid uptake and translocation for storage under iron overload. This study reveals a completely novel pathway in which sgk-1 plays a central role to synergistically regulate iron and lipid homeostasis, offering not only experimental evidence supporting a previously unverified link between iron and obesity, but also novel insights into the pathogenesis of iron and obesity-related human metabolic diseases.
C1 [Wang, Haizhen; Jiang, Xue; Wu, Jieyu; Zhang, Linqiang; Zhang, Yuru; Liang, Bin] Chinese Acad Sci, Kunming Inst Zool, Chinese Acad Sci & Yunnan Prov, Key Lab Anim Models & Human Dis Mech, Kunming 650223, Peoples R China.
   [Wang, Haizhen; Jiang, Xue; Wu, Jieyu; Zhang, Linqiang] Univ Chinese Acad Sci, Kunming Coll Life Sci, Kunming 650204, Yunnan, Peoples R China.
   [Huang, Jingfei] Chinese Acad Sci, Kunming Inst Zool, State Key Lab Genet Resources & Evolut, Kunming 650223, Peoples R China.
   [Zou, Xiaoju] Kunming Univ, Dept Life Sci & Biotechnol, Key Lab Special Biol Resource Dev & Utilizat Univ, Kunming 650214, Peoples R China.
C3 Chinese Academy of Sciences; Kunming Institute of Zoology, CAS; Chinese
   Academy of Sciences; University of Chinese Academy of Sciences, CAS;
   Chinese Academy of Sciences; Kunming Institute of Zoology, CAS; Kunming
   University
RP Liang, B (corresponding author), Kunming Inst Zool, 32 Jiaochangdonglu Rd, Kunming 650223, Peoples R China.; Zou, XJ (corresponding author), Kunming Univ, Key Lab Special Biol Resource Dev & Utilizat Univ, Dept Life Sci & Biotechnol, Kunming 650214, Peoples R China.
EM xiaojuzou@163.com; liangb@mail.kiz.ac.cn
RI Liang, Bin/CAI-9764-2022; Jiang, Xue/K-2461-2019; Wu,
   Jieyu/HZI-3244-2023
OI Zhang, Linqiang/0000-0001-7423-2320; liang, bin/0000-0001-9131-5478; Wu,
   Jieyu/0000-0003-3638-9313; Wang, Haizhen/0000-0001-8135-4297
FU National Institutes of Health Office of Research Infrastructure Programs
   [P40 OD010440]; Strategic Priority Research Program of the Chinese
   Academy of Sciences [XDB13030600]; National Natural Science Foundation
   of China [31460268, 31160216, 31171134, U1202223]; Yunnan Natural
   Science Foundation [2013FA042, 2011FZ179]; Yunnan Provincial Science and
   Technology Department [2014HB022]; Yunnan Overseas High-Level Talents
   Program [2015HA040]; State Key Laboratory of Genetic Resources and
   Evolution [GREKF13-03]
FX We express our deep gratitude to Jennifer L. Watts for helpful comments
   on the manuscript; Mengqiu Dong for kindly providing the sgk-1::gfp
   (MQD862, N2; Psgk1::sgk-1::gfp) worm strain; and Shouhong Guang for
   EG4322, pCFJ151, pJL43.1, pCFJ104, and pCFJ90 constructs. Some strains
   were provided by the Caenorhabditis Genetics Center, which is funded by
   the National Institutes of Health Office of Research Infrastructure
   Programs (P40 OD010440). This work was supported by the Strategic
   Priority Research Program of the Chinese Academy of Sciences
   (XDB13030600), the National Natural Science Foundation of China
   (31460268, 31160216, 31171134, and U1202223), the Yunnan Natural Science
   Foundation (2013FA042 and 2011FZ179), the Yunnan Provincial Science and
   Technology Department (2014HB022), the Yunnan Overseas High-Level
   Talents Program (2015HA040 to B.L.), and the State Key Laboratory of
   Genetic Resources and Evolution (GREKF13-03).
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NR 67
TC 32
Z9 40
U1 0
U2 40
PU GENETICS SOCIETY AMERICA
PI BETHESDA
PA 9650 ROCKVILLE AVE, BETHESDA, MD 20814 USA
SN 0016-6731
EI 1943-2631
J9 GENETICS
JI Genetics
PD MAY
PY 2016
VL 203
IS 1
BP 241
EP +
DI 10.1534/genetics.116.186742
PG 25
WC Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Genetics & Heredity
GA DM0DD
UT WOS:000376012100017
PM 27017620
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Bhatt, MP
   Lim, YC
   Kim, YM
   Ha, KS
AF Bhatt, Mahendra Prasad
   Lim, Young-Cheol
   Kim, Young-Myeong
   Ha, Kwon-Soo
TI C-Peptide Activates AMPKα and Prevents ROS-Mediated Mitochondrial
   Fission and Endothelial Apoptosis in Diabetes
SO DIABETES
LA English
DT Article
ID OXYGEN SPECIES PRODUCTION; NITRIC-OXIDE SYNTHASE; PROTEIN-KINASE-C;
   OXIDATIVE STRESS; NAD(P)H OXIDASE; METABOLIC SYNDROME; IN-VIVO; CELLS;
   DYSFUNCTION; HYPERGLYCEMIA
AB Vasculopathy is a major complication of diabetes; however, molecular mechanisms mediating the development of vasculopathy and potential strategies for prevention have not been identified. We have previously reported that C-peptide prevents diabetic vasculopathy by inhibiting reactive oxygen species (ROS)-mediated endothelial apoptosis. To gain further insight into ROS-dependent mechanism of diabetic vasculopathy and its prevention, we studied high glucose-induced cytosolic and mitochondrial ROS production and its effect on altered mitochondrial dynamics and apoptosis. For the therapeutic strategy, we investigated the vasoprotective mechanism of C-peptide against hyperglycemia-induced endothelial damage through the AMP-activated protein kinase (AMPK) pathway using human umbilical vein endothelial cells and aorta of diabetic mice. High glucose (33 mmol/L) increased intracellular ROS through a mechanism involving interregulation between cytosolic and mitochondrial ROS generation. C-peptide (1 nmol/L) activation of AMPK inhibited high glucose-induced ROS generation, mitochondrial fission, mitochondrial membrane potential collapse, and endothelial cell apoptosis. Additionally, the AMPK activator 5-aminoimidazole-4-carboxamide 1--d-ribofuranoside and the antihyperglycemic drug metformin mimicked protective effects of C-peptide. C-peptide replacement therapy normalized hyperglycemia-induced AMPK dephosphorylation, ROS generation, and mitochondrial disorganization in aorta of diabetic mice. These findings highlight a novel mechanism by which C-peptide activates AMPK and protects against hyperglycemia-induced vasculopathy.
C1 [Bhatt, Mahendra Prasad; Lim, Young-Cheol; Kim, Young-Myeong; Ha, Kwon-Soo] Kangwon Natl Univ, Sch Med, Dept Mol & Cellular Biochem, Chunchon, South Korea.
C3 Kangwon National University
RP Ha, KS (corresponding author), Kangwon Natl Univ, Sch Med, Dept Mol & Cellular Biochem, Chunchon, South Korea.
EM ksha@kangwon.ac.kr
RI Ha, Kwon-Soo/AAU-4417-2020; kim, jeeyoung/AFK-5620-2022
OI Ha, Kwon-Soo/0000-0002-4219-1787; Bhatt, Mahendra
   Prasad/0000-0001-9910-8668
FU Korea Research Foundation of Korea [2008-05943, 2013-008193]; Ministry
   of Health and Welfare through the National R&D Program for Cancer
   Control [1020420]
FX This work was supported in part by Korea Research Foundation of Korea
   grants (2008-05943 and 2013-008193) and by the Ministry of Health and
   Welfare through the National R&D Program for Cancer Control (1020420).
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NR 46
TC 143
Z9 155
U1 0
U2 21
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0012-1797
EI 1939-327X
J9 DIABETES
JI Diabetes
PD NOV
PY 2013
VL 62
IS 11
BP 3851
EP 3862
DI 10.2337/db13-0039
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 243BF
UT WOS:000326290700029
PM 23884890
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Frontoni, S
   Di Bartolo, P
   Avogaro, A
   Bosi, E
   Paolisso, G
   Ceriello, A
AF Frontoni, Simona
   Di Bartolo, Paolo
   Avogaro, Angelo
   Bosi, Emanuele
   Paolisso, Giuseppe
   Ceriello, Antonio
TI Glucose variability: An emerging target for the treatment of diabetes
   mellitus
SO DIABETES RESEARCH AND CLINICAL PRACTICE
LA English
DT Review
DE Glucose variability; Diabetic complications; Treatment
ID FASTING PLASMA-GLUCOSE; GLYCEMIC VARIABILITY; BLOOD-GLUCOSE;
   POSTPRANDIAL HYPERGLYCEMIA; MICROVASCULAR COMPLICATIONS; CARDIOVASCULAR
   OUTCOMES; OXIDATIVE STRESS; NOCTURNAL HYPOGLYCEMIA; METABOLIC SYNDROME;
   TYPE-1
AB Alterations in glucose metabolism in individuals with diabetes have been considered for many years, as they appear at first glance, i.e., simply as hyperglycemia, and its surrogate marker, glycated hemoglobin (HbA(1c)), used both to estimate the risk of developing diabetic complications and to define the targets and measure the efficacy of diabetes treatments.
   However, over time diabetes-related glycemic alterations have been considered in more complex terms, by attempting to identify the role of fasting glycemia, postprandial glycemia and hypoglycemia in the overall assessment of the disease.
   This set of evaluations has led to the concept of glucose variability. Although intuitively easy to understand, it cannot be equally simply translated into terms of definition, measuring, prognostic and therapeutic impact. The literature available on glucose variability is extensive yet confused, with the only common element being the need to find out more on the subject.
   The purpose of this manuscript is not only to review the most recent evidence on glucose variability, but also to help the reader to better understand the available measurement options, and how the various definitions can differently be related with the development of diabetic complications. Finally, we provide how new and old drugs can impact on glucose variability. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
C1 [Frontoni, Simona] Univ Roma Tor Vergata, Dipartimento Med Sistemi, I-00173 Rome, Italy.
   [Avogaro, Angelo] Univ Padua, Dipartimento Med, I-35100 Padua, Italy.
   [Bosi, Emanuele] Univ Vita Salute San Raffaele, Ist Sci San Raffaele, Dipartimento Med Interna & Specialist, Milan, Italy.
   [Paolisso, Giuseppe] Univ Naples 2, Dipartimento Geriatria & Malattie Metab, Naples, Italy.
   [Ceriello, Antonio] IDIBAPS, Barcelona, Spain.
C3 University of Rome Tor Vergata; University of Padua; Vita-Salute San
   Raffaele University; IRCCS Ospedale San Raffaele; Universita della
   Campania Vanvitelli; University of Barcelona; Hospital Clinic de
   Barcelona; IDIBAPS
RP Ceriello, A (corresponding author), IDIBAPS, Barcelona, Spain.
EM aceriell@clinic.ub.es
RI Avogaro, Angelo/S-3808-2016; FRONTONI, SIMONA/J-4893-2012; Ceriello,
   Antonio/J-9575-2016; paolisso, giuseppe/AAP-8516-2020; Di Bartolo,
   Paolo/AAL-5954-2021
OI Di Bartolo, Paolo/0000-0001-5957-1551; Ceriello,
   Antonio/0000-0001-8122-3203; FRONTONI, SIMONA/0000-0001-8241-7552;
   AVOGARO, ANGELO/0000-0002-1177-0516
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NR 91
TC 126
Z9 131
U1 0
U2 26
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0168-8227
EI 1872-8227
J9 DIABETES RES CLIN PR
JI Diabetes Res. Clin. Pract.
PD NOV
PY 2013
VL 102
IS 2
BP 86
EP 95
DI 10.1016/j.diabres.2013.09.007
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 263GR
UT WOS:000327796000012
PM 24128999
DA 2025-06-11
ER

PT J
AU Nagahora, N
   Ito, Y
   Nagasawa, T
AF Nagahora, Nozomi
   Ito, Yoshiaki
   Nagasawa, Takashi
TI Dietary Chinese Quince Polyphenols Suppress Generation of α-Dicarbonyl
   Compounds in Diabetic KK-A<SUP>y</SUP> Mice
SO JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
LA English
DT Article
DE antidiabetic effect; green tea extract; phenols; procyanidin; Chinese
   quince; glycation; alpha-dicarbonyl compounds
ID PINE BARK EXTRACT; GREEN TEA; OXIDATIVE STRESS; OLIGOMERIC PROCYANIDINS;
   METABOLIC SYNDROME; INDUCED OBESITY; GRAPE SEED; GLYCATION;
   SUPPLEMENTATION; FRUITS
AB Many dietary polyphenols can provide health benefits, such as antioxidant and antidiabetic effects, and can down-regulate the progression of glycation (one cause of diabetic complications). Chinese quince (CQ) is rich in polyphenols, especially procyanidins. A few studies have indicated that CQ has an effect on diabetes. In this study, a procyaniclin-rich extract was prepared from Chinese quince fruit (CQE), and its effects were investigated and compared with those of green tea extract (GTE) in type 2 diabetes model KK-A(y)? mice. Mice were provided one of two high fat (HF) diets for 4 weeks: a HF diet containing 0.5% CQE or a HF diet containing 0.5% GTE. Blood glucose was suppressed in mice fed CQE and GTE during the experimental period (p < 0.05), although the effect of CQE was weaker than that of GTE. Intake of CQE had no effect on the blood insulin level, whereas GTE decreased the insulin level. Body weight gain was suppressed in mice fed CQE similarly to mice fed GTE (p < 0.05). Hepatic lipid content and a-dicarbonyl compounds in the kidney were reduced in mice fed CQE and GTE (p < 0.05). These results suggest that intake of CQE could moderate type 2 diabetes and diabetic complications.
C1 [Nagahora, Nozomi; Ito, Yoshiaki; Nagasawa, Takashi] Iwate Univ, United Grad Sch Agr Sci, Morioka, Iwate 0208550, Japan.
C3 Iwate University
RP Nagasawa, T (corresponding author), Iwate Univ, United Grad Sch Agr Sci, 3-18-8 Ueda, Morioka, Iwate 0208550, Japan.
EM tnaga@iwate-u.ac.jp
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NR 51
TC 9
Z9 9
U1 0
U2 31
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0021-8561
EI 1520-5118
J9 J AGR FOOD CHEM
JI J. Agric. Food Chem.
PD JUL 10
PY 2013
VL 61
IS 27
BP 6629
EP 6635
DI 10.1021/jf401231j
PG 7
WC Agriculture, Multidisciplinary; Chemistry, Applied; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture; Chemistry; Food Science & Technology
GA 183JF
UT WOS:000321810300006
PM 23730977
DA 2025-06-11
ER

PT J
AU Kim, B
   Sullivan, KA
   Backus, C
   Feldman, EL
AF Kim, Bhumsoo
   Sullivan, Kelli A.
   Backus, Carey
   Feldman, Eva L.
TI Cortical Neurons Develop Insulin Resistance and Blunted Akt Signaling: A
   Potential Mechanism Contributing to Enhanced Ischemic Injury in Diabetes
SO ANTIOXIDANTS & REDOX SIGNALING
LA English
DT Article
ID MIDDLE-AGED MEN; RISK-FACTORS; ISCHEMIA/REPERFUSION INJURY;
   ATHEROSCLEROSIS RISK; METABOLIC SYNDROME; CEREBRAL-ISCHEMIA; OXIDATIVE
   STRESS; HEART-DISEASE; S6 KINASE; FOLLOW-UP
AB Patients with diabetes are at higher risk of stroke and experience increased morbidity and mortality after stroke. We hypothesized that cortical neurons develop insulin resistance, which decreases neuroprotection via circulating insulin and insulin-like growth factor-I (IGF-I). Acute insulin treatment of primary embryonic cortical neurons activated insulin signaling including phosphorylation of the insulin receptor, extracellular signal-regulated kinase (ERK), Akt, p70S6K, and glycogen synthase kinase-3 beta (GSK-3 beta). To mimic insulin resistance, cortical neurons were chronically treated with 25 mM glucose, 0.2 mM palmitic acid (PA), or 20 nM insulin before acute exposure to 20 nM insulin. Cortical neurons pretreated with insulin, but not glucose or PA, exhibited blunted phosphorylation of Akt, p70S6K, and GSK-3 beta with no change detected in ERK. Inhibition of the phosphatidylinositol 3-kinase (PI3-K) pathway during insulin pretreatment restored acute insulin-mediated Akt phosphorylation. Cortical neurons in adult BKS-db/db mice exhibited higher basal Akt phosphorylation than BKS-db(+) mice and did not respond to insulin. Our results indicate that prolonged hyperinsulinemia leads to insulin resistance in cortical neurons. Decreased sensitivity to neuroprotective ligands may explain the increased neuronal damage reported in both experimental models of diabetes and diabetic patients after ischemia-reperfusion injury. Antioxid. Redox Signal. 14, 1829-1839.
C1 [Kim, Bhumsoo; Sullivan, Kelli A.; Backus, Carey; Feldman, Eva L.] Univ Michigan, Dept Neurol, Ann Arbor, MI 48109 USA.
C3 University of Michigan System; University of Michigan
RP Kim, B (corresponding author), Univ Michigan, Dept Neurol, 109 Zina Pitcher Pl,5371 BSRB, Ann Arbor, MI 48109 USA.
EM bhumsoo@umich.edu
OI Feldman, Eva/0000-0002-9162-2694; Sullivan, Kelli/0009-0002-6904-6587
FU National Institutes of Health [NIH UO1 DK076160, NIH R24 DK082840-01];
   Program for Neurology Research and Discovery
FX This work was supported by the National Institutes of Health (NIH UO1
   DK076160 and NIH R24 DK082840-01) and the Program for Neurology Research
   and Discovery (www.pnrd.umich.edu).
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NR 71
TC 79
Z9 84
U1 0
U2 15
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1523-0864
EI 1557-7716
J9 ANTIOXID REDOX SIGN
JI Antioxid. Redox Signal.
PD MAY
PY 2011
VL 14
IS 10
BP 1829
EP 1839
DI 10.1089/ars.2010.3816
PG 11
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 751NJ
UT WOS:000289624500006
PM 21194385
OA Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Wolfrum, C
   Howell, JJ
   Ndungo, E
   Stoffel, M
AF Wolfrum, Christian
   Howell, Jessica J.
   Ndungo, Esther
   Stoffel, Markus
TI Foxa2 activity increases plasma high density lipoprotein levels by
   regulating apolipoprotein M
SO JOURNAL OF BIOLOGICAL CHEMISTRY
LA English
DT Article
ID PRE-BETA-HDL; HEPATOCYTE NUCLEAR FACTOR-1-ALPHA; DEPENDENT
   DIABETES-MELLITUS; ELEVATED OXIDATIVE STRESS; CORONARY-ARTERY-DISEASE;
   INSULIN-RESISTANCE; A-I; ANTIOXIDATIVE ACTIVITY; MAGNETIC-RESONANCE;
   METABOLIC SYNDROME
AB Obesity, diabetes, insulin resistance, and hyperinsulinemia are frequently associated with a cluster of closely related lipid abnormalities such as low plasma levels of high density lipoprotein (HDL) and elevated levels of triglyceride, both known to increase the risk of developing atherosclerotic disease. The molecular mechanisms linking obesity, insulin resistance, and hyperinsulinemia to low HDL levels are incompletely understood. Here we demonstrate that insulin, through a Foxa2-mediated mechanism, inhibited the expression of apolipoprotein M(apoM), an important determinant of plasma pre-beta-HDL and alpha-HDL concentrations. Obese mice had decreased apoM expression and plasma pre-beta-HDL levels due to inactivation of Foxa2 in hyperinsulinemic states. Nuclear reexpression of Foxa2 with a phosphorylation-deficient mutant Foxa2T156A (Ad-T156A) activated apoM expression and increased plasma pre-beta-HDL and alpha-HDL levels. In contrast, haploinsufficient Foxa2(+/-) mice exhibited decreased hepatic apoM expression and plasma pre-beta-HDL and HDL levels. The increase in plasma HDL levels and pre-beta-HDL formation by Foxa2 was mediated exclusively by apoM, as constitutive active expression of Foxa2 in apoM(-/-) mice had no effect on plasma HDL levels. Our results identify a fundamental mechanism by which insulin regulates plasma HDL levels in physiological and insulin-resistant states and thus have important implications for novel therapeutic approaches to prevent atherosclerosis.
C1 [Wolfrum, Christian; Howell, Jessica J.; Stoffel, Markus] ETH, Swiss Fed Inst Technol, Inst Mol Syst Biol, CH-8093 Zurich, Switzerland.
   [Wolfrum, Christian; Howell, Jessica J.; Stoffel, Markus] ETH, Competence Ctr Syst Physiol & Metab Dis, CH-8093 Zurich, Switzerland.
   [Howell, Jessica J.; Ndungo, Esther; Stoffel, Markus] Rockefeller Univ, New York, NY 10021 USA.
C3 Swiss Federal Institutes of Technology Domain; ETH Zurich; Swiss Federal
   Institutes of Technology Domain; ETH Zurich; Rockefeller University
RP Stoffel, M (corresponding author), ETH, Swiss Fed Inst Technol, Inst Mol Syst Biol, HPTE73,Wolfgang Pauli Str 16, CH-8093 Zurich, Switzerland.
EM stoffel@imsb.biol.ethz.ch
OI Stoffel, Markus/0000-0003-1304-5817; Wolfrum,
   Christian/0000-0002-3862-6805; Ndungo, Esther/0000-0002-9975-7032
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NR 51
TC 62
Z9 69
U1 0
U2 3
PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3996 USA
EI 1083-351X
J9 J BIOL CHEM
JI J. Biol. Chem.
PD JUN 13
PY 2008
VL 283
IS 24
BP 16940
EP 16949
DI 10.1074/jbc.M801930200
PG 10
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 309YW
UT WOS:000256497100071
PM 18381283
DA 2025-06-11
ER

PT J
AU Al-Beltagi, M
   Bediwy, AS
   Saeed, NK
   Bediwy, HA
   Elbeltagi, R
AF Al-Beltagi, Mohammed
   Bediwy, Adel Salah
   Saeed, Nermin Kamal
   Bediwy, Hosameldin A.
   Elbeltagi, Reem
TI Diabetes-inducing effects of bronchial asthma
SO WORLD JOURNAL OF DIABETES
LA English
DT Article
DE Diabetes mellitus; Bronchial asthma; Glycemic control; Lung function;
   Asthma exacerbation; Disease interaction; Microangiopathy
ID GLUCAGON-LIKE PEPTIDE-1; COMMUNITY-ACQUIRED PNEUMONIA; REDUCED
   PULMONARY-FUNCTION; INSULIN-RESISTANCE; LUNG-FUNCTION; METABOLIC
   SYNDROME; INHALED CORTICOSTEROIDS; GLUCOSE-HOMEOSTASIS; INCREASED RISK;
   BLOOD-GLUCOSE
AB BACKGROUND The relationship between diabetes mellitus (DM) and asthma is complex and can impact disease trajectories. AIM To explore the bidirectional influences between the two conditions on clinical outcomes and disease control. METHODS We systematically reviewed the literature on the relationship between DM and asthma, focusing on their impacts, mechanisms, and therapeutic implications. Various studies were assessed, which investigated the effect of glycemic control on asthma outcomes, lung function, and exacerbations. The study highlighted the role of specific diabetes medications in managing asthma. RESULTS The results showed that poor glycemic control in diabetes can exacerbate asthma, increase hospitalizations, and reduce lung function. Conversely, severe asthma, especially in obese individuals, can complicate diabetes management and make glycemic control more difficult. The diabetes-associated mechanisms, such as inflammation, microangiopathy, and oxidative stress, can exacerbate asthma and decrease lung function. Some diabetes medications exhibit anti-inflammatory effects that show promise in mitigating asthma exacerbations. CONCLUSION The complex interrelationship between diabetes and asthma suggests bidirectional influences that affect disease course and outcomes. Inflammation and microvascular complications associated with diabetes may worsen asthma outcomes, while asthma severity, especially in obese individuals, complicates diabetes control. However, the current research has limitations, and more diverse longitudinal studies are required to establish causal relationships and identify effective treatment strategies for individuals with both conditions.
C1 [Al-Beltagi, Mohammed] Tanta Univ, Fac Med, Dept Pediat, Al Bahr St, Alghrabia 31511, Egypt.
   [Al-Beltagi, Mohammed] Arabian Gulf Univ, Univ Med Ctr, King Abdulla Med City, Dept Pediat, Manama 26671, Bahrain.
   [Bediwy, Adel Salah] Tanta Univ, Fac Med, Dept Pulmonol, Alghrabia 31527, Egypt.
   [Bediwy, Adel Salah] Arabian Gulf Univ, Univ Med Ctr, King Abdulla Med City, Dept Pulmonol, Manama 26671, Bahrain.
   [Saeed, Nermin Kamal] ?Minist Hlth, Dept Pathol, Med Microbiol Sect, Salmaniya Med Complex, Manama 26671, Bahrain.
   [Saeed, Nermin Kamal] Irish Royal Coll Surg, Dept Pathol, Med Microbiol Sect, Muharraq 15503, Bahrain.
   [Bediwy, Hosameldin A.] Tanta Univ, Fac Med, Algharbia 31527, Egypt.
   [Elbeltagi, Reem] Royal Coll Surg Ireland Bahrain, Dept Med, Muharraq 15503, Bahrain.
C3 Egyptian Knowledge Bank (EKB); Tanta University; Arabian Gulf
   University; Egyptian Knowledge Bank (EKB); Tanta University; Arabian
   Gulf University; Ministry of Health - Bahrain; Royal College of Surgeons
   - Ireland; Royal College of Surgeons in Ireland - Medical University of
   Bahrain; Egyptian Knowledge Bank (EKB); Tanta University; Royal College
   of Surgeons - Ireland; Royal College of Surgeons in Ireland - Medical
   University of Bahrain
RP Al-Beltagi, M (corresponding author), Tanta Univ, Fac Med, Dept Pediat, Al Bahr St, Alghrabia 31511, Egypt.
EM mbelrem@hotmail.com
RI Saeed, Nermin/AAX-5996-2020; Al-Biltagi, Mohammed/I-5665-2013; Bediwy,
   Adel/T-3716-2019
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NR 169
TC 0
Z9 0
U1 1
U2 1
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 7041 Koll Center Parkway, Suite 160, PLEASANTON, CA, UNITED STATES
EI 1948-9358
J9 WORLD J DIABETES
JI World J. Diabetes
PD JAN 15
PY 2025
VL 16
IS 1
AR 97954
DI 10.4239/wjd.v16.i1.97954
PG 20
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA U7J5E
UT WOS:001413510800017
PM 39817208
DA 2025-06-11
ER

PT J
AU Chae, HS
   Cantrell, CL
   Khan, IA
   Jarret, RL
   Khan, SI
AF Chae, Hee-Sung
   Cantrell, Charles L.
   Khan, Ikhlas A.
   Jarret, Robert L.
   Khan, Shabana I.
TI Capsiate-Rich Fraction of Capsicum annuum Induces Muscular Glucose
   Uptake, Ameliorates Rosiglitazone-Induced Adipogenesis, and Exhibits
   Activation of NRs Regulating Multiple Signaling Pathways
SO JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
LA English
DT Article
DE Capsicum annuum; capsiate; rosiglitazone; adipogenesis; glucose uptake
ID LIVER-X-RECEPTOR; OXIDATIVE STRESS; CAPSAICIN; OBESITY; NRF2;
   INFLAMMATION; METABOLISM
AB Capsiate is a key ingredient in the fruits of a nonpungent cultivar of Capsicum annuum. We investigated the effects of a C. annuum extract (CE) and a capsiate-rich fraction of CE (CR) on nuclear receptors involved in multiple signaling pathways, glucose uptake, and adipogenesis in comparison to pure capsiate (Ca). Similar to the effect of Ca (100 mu M), CE (500 mu g/mL) and CR (100 mu g/mL) caused the activation of PPAR alpha and PPAR gamma (>3-fold), while CR also activated LXR and NRF2 (>2 fold). CR (200 mu g/mL) and Ca (100 mu M) decreased lipid accumulation (22.6 +/- 14.1 and 49.7 +/- 7.3%, respectively) in adipocytes and increased glucose uptake (44.7 +/- 6.2 and 30.1 +/- 12.2%, respectively) in muscle cells and inhibited the adipogenic effect induced by rosiglitazone by 41.2 +/- 5.6 and 13.9 +/- 4.3%, respectively. This is the first report to reveal the agonistic action of CR and Ca on multiple nuclear receptors along with their enhanced glucose uptake and antiadipogenic effects. The results indicate the potential utility of the capsiate-rich fraction of C. annuum in alleviating the symptoms of metabolic syndrome and in preventing the undesired adipogenic effects of full PPAR gamma agonists such as rosiglitazone.
C1 [Chae, Hee-Sung; Khan, Ikhlas A.; Khan, Shabana I.] Univ Mississippi, Natl Ctr Nat Prod Res, Sch Pharm, University, MS 38677 USA.
   [Cantrell, Charles L.] USDA, Nat Prod Utilizat Res Unit, ARS, University, MS 38677 USA.
   [Khan, Ikhlas A.; Khan, Shabana I.] Univ Mississippi, Sch Pharm, Dept BioMol Sci, University, MS 38677 USA.
   [Jarret, Robert L.] USDA, Plant Genet Resources Unit, ARS, Griffin, GA 30223 USA.
C3 University of Mississippi; United States Department of Agriculture
   (USDA); University of Mississippi; United States Department of
   Agriculture (USDA)
RP Khan, SI (corresponding author), Univ Mississippi, Natl Ctr Nat Prod Res, Sch Pharm, University, MS 38677 USA.; Khan, SI (corresponding author), Univ Mississippi, Sch Pharm, Dept BioMol Sci, University, MS 38677 USA.
EM skhan@olemiss.edu
RI chae, hee-sung/AAU-8460-2021; Khan, Ikhlas/AAA-1490-2020
OI Cantrell, Charles/0000-0002-5163-9045; Khan, Shabana/0000-0001-6429-7219
FU Agricultural Research Service [58-6060-1-001]; United States Department
   of Agriculture, Agriculture Research Service (USDA-ARS)
FX This work was supported in part by the United States Department of
   Agriculture, Agriculture Research Service (USDA-ARS) Cooperative
   Agreement No. 58-6060-1-001. Excellent technical help from Ms. Olivia
   Dale and Ms. Katherine Martin is also acknowledged.
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NR 52
TC 5
Z9 5
U1 2
U2 2
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0021-8561
EI 1520-5118
J9 J AGR FOOD CHEM
JI J. Agric. Food Chem.
PD NOV 16
PY 2023
VL 71
IS 47
BP 18395
EP 18404
DI 10.1021/acs.jafc.3c06148
PG 10
WC Agriculture, Multidisciplinary; Chemistry, Applied; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture; Chemistry; Food Science & Technology
GA Z3LJ2
UT WOS:001111118500001
PM 37972244
DA 2025-06-11
ER

PT J
AU Wang, AN
   Fraser, GM
   McGuire, JJ
AF Wang, Andrea N.
   Fraser, Graham M.
   McGuire, John J.
TI Characterization of Endothelium-Dependent Relaxation in the Saphenous
   Artery and Its Caudal Branches in Young and Old Adult Sprague Dawley
   Rats
SO BIOMOLECULES
LA English
DT Article
DE endothelium; nitric oxide; proteinase-activated receptor 2; ageing;
   cardiovascular system
ID ACTIVATED RECEPTOR 2; MUSCLE BLOOD-FLOW; NITRIC-OXIDE;
   MESENTERIC-ARTERIES; RESISTANCE VESSELS; VASCULAR-RESPONSES; METABOLIC
   SYNDROME; OXIDATIVE STRESS; FEMORAL-ARTERY; DYSFUNCTION
AB Ageing is associated with reduced endothelium-derived nitric oxide (NO) production in the femoral artery of Sprague Dawley (SD) rats. In the current study, we examined endotheliumdependent relaxation (EDR) in the saphenous artery and its caudal branches. We used acetylcholine and the Proteinase-Activated receptor-2 (PAR2)-specific agonist (2fLIGRLO) with nitroarginine methylester (L-NAME) to assess EDR in two groups of male SD rats (age in weeks: young, 10-12; old, 27-29). Acetylcholine and 2fLIGRLO were potent NO-dependent relaxant agents in all arteries. For all arteries, EDR by acetylcholine decreased significantly in old compared to young SD rats. Interestingly, PAR2-induced EDR of proximal saphenous artery segments and caudal branches decreased significantly in old compared to young, but did not differ for the in-between middle and distal ends of the saphenous artery. L-NAME treatment increased subsequent contractions of proximal and middle segments of saphenous arteries by phenylephrine and U46619 in young, but not in old, SD rats. We conclude the SD saphenous artery and caudal branches exhibit regional characteristics that differ in response to specific EDR agonists, endothelial NO synthase inhibitor, and changes to endothelium function with increased age, which are, in part, attributed to decreased sensitivity of vascular smooth muscle to the gaseous transmitter NO.
C1 [Wang, Andrea N.; McGuire, John J.] Western Univ, Schulich Sch Med & Dent, Dept Med Biophys, London, ON N6A 5C1, Canada.
   [Fraser, Graham M.] Memorial Univ, Fac Med, Div BioMed Sci, St John, NL A1B 3V6, Canada.
   [McGuire, John J.] Western Univ, Schulich Sch Med & Dent, Dept Physiol & Pharmacol, London, ON N6A 5C1, Canada.
C3 Western University (University of Western Ontario); Memorial University
   Newfoundland; Western University (University of Western Ontario)
RP McGuire, JJ (corresponding author), Western Univ, Schulich Sch Med & Dent, Dept Med Biophys, London, ON N6A 5C1, Canada.; McGuire, JJ (corresponding author), Western Univ, Schulich Sch Med & Dent, Dept Physiol & Pharmacol, London, ON N6A 5C1, Canada.
EM awang293@uwo.ca; graham.fraser@med.mun.ca; john.mcguire@schulich.uwo.ca
OI McGuire, John/0000-0003-0302-3884
FU Canadian Institutes of Health Research [PJT-162199]; Natural Sciences
   and Engineering Research Council of Canada [RGPIN 4536-2017]; Western
   University's School of Graduate Studies
FX This research was funded by the Canadian Institutes of Health Research
   (PJT-162199) and Natural Sciences and Engineering Research Council of
   Canada (RGPIN 4536-2017). A.N.W. was awarded a scholarship fromWestern
   University's School of Graduate Studies.
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NR 57
TC 1
Z9 2
U1 0
U2 4
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2218-273X
J9 BIOMOLECULES
JI Biomolecules
PD JUL
PY 2022
VL 12
IS 7
AR 889
DI 10.3390/biom12070889
PG 15
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 3G5LI
UT WOS:000831395600001
PM 35883445
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Juszczak, F
   Vlassembrouck, M
   Botton, O
   Zwakhals, T
   Decarnoncle, M
   Tassin, A
   Caron, N
   Declèves, AE
AF Juszczak, Florian
   Vlassembrouck, Maud
   Botton, Olivia
   Zwakhals, Thomas
   Decarnoncle, Morgane
   Tassin, Alexandra
   Caron, Nathalie
   Decleves, Anne-Emilie
TI Delayed Exercise Training Improves Obesity-Induced Chronic Kidney
   Disease by Activating AMPK Pathway in High-Fat Diet-Fed Mice
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE high-fat diet; chronic kidney disease; endurance exercise training;
   AMPK; autophagy; ectopic lipid accumulation
ID INSULIN-RESISTANCE; METABOLIC SYNDROME; ABDOMINAL OBESITY;
   PROTEIN-KINASE; WEIGHT-LOSS; ADIPONECTIN; AUTOPHAGY; INSUFFICIENCY;
   PREVALENCE; REDUCTION
AB Exercise training is now recognized as an interesting therapeutic strategy in managing obesity and its related disorders. However, there is still a lack of knowledge about its impact on obesity-induced chronic kidney disease (CKD). Here, we investigated the effects of a delayed protocol of endurance exercise training (EET) as well as the underlying mechanism in obese mice presenting CKD. Mice fed a high-fat diet (HFD) or a low-fat diet (LFD) for 12 weeks were subsequently submitted to an 8-weeks EET protocol. Delayed treatment with EET in obese mice prevented body weight gain associated with a reduced calorie intake. EET intervention counteracted obesity-related disorders including glucose intolerance, insulin resistance, dyslipidaemia and hepatic steatosis. Moreover, our data demonstrated for the first time the beneficial effects of EET on obesity-induced CKD as evidenced by an improvement of obesity-related glomerulopathy, tubulo-interstitial fibrosis, inflammation and oxidative stress. EET also prevented renal lipid depositions in the proximal tubule. These results were associated with an improvement of the AMPK pathway by EET in renal tissue. AMPK-mediated phosphorylation of ACC and ULK-1 were particularly enhanced leading to increased fatty acid oxidation and autophagy improvement with EET in obese mice.
C1 [Juszczak, Florian; Vlassembrouck, Maud; Zwakhals, Thomas; Decarnoncle, Morgane; Decleves, Anne-Emilie] Univ Mons UMONS, Res Inst Hlth Sci & Technol, Fac Med & Pharm, Lab Metab & Mol Biochem, B-7000 Mons, Belgium.
   [Juszczak, Florian; Botton, Olivia; Caron, Nathalie] Univ Namur UNamur, Namur Res Inst Life Sci NARILIS, Mol Physiol Res Unit URPhyM, B-5000 Namur, Belgium.
   [Tassin, Alexandra] Univ Mons UMONS, Res Inst Hlth Sci & Technol, Fac Med & Pharm, Lab Resp Physiol Pathophysiol & Rehabil, B-7000 Mons, Belgium.
C3 University of Mons; University of Mons
RP Juszczak, F (corresponding author), Univ Mons UMONS, Res Inst Hlth Sci & Technol, Fac Med & Pharm, Lab Metab & Mol Biochem, B-7000 Mons, Belgium.; Juszczak, F (corresponding author), Univ Namur UNamur, Namur Res Inst Life Sci NARILIS, Mol Physiol Res Unit URPhyM, B-5000 Namur, Belgium.
EM florian.juszczak@umons.ac.be; maudvlassembrouck@gmail.com;
   olivia.botton@unamur.be; Thomas.ZWAKHALS@umons.ac.be;
   Morgane.decarnoncle@student.umons.ac.be; Alexandra.TASSIN@umons.ac.be;
   nathalie.caron@unamur.be; anne-emilie.decleves@umons.ac.be
OI Botton, Olivia/0000-0003-0821-4380; Decarnoncle,
   Morgane/0000-0003-3259-4109; DECLEVES, ANNE-EMILIE/0000-0002-0838-2432;
   Juszczak, Florian/0000-0001-8526-0204; Tassin,
   Alexandra/0000-0002-2154-7529
FU UMONS Research Institute for Health Sciences and Technology (Belgium);
   FRMH (Fonds pour la Recherche Medicale dans le Hainaut, Belgium)
FX This work was supported by grants from the UMONS Research Institute for
   Health Sciences and Technology (Belgium) and the FRMH (Fonds pour la
   Recherche Medicale dans le Hainaut, Belgium).
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NR 72
TC 21
Z9 22
U1 0
U2 13
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD JAN
PY 2021
VL 22
IS 1
AR 350
DI 10.3390/ijms22010350
PG 20
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA PQ0XL
UT WOS:000606273800001
PM 33396267
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Tsai, HP
   Hou, PH
   Mao, FC
   Chang, CC
   Yang, WC
   Wu, CF
   Liao, HJ
   Lin, TC
   Chou, LS
   Hsiao, LW
   Chang, GR
AF Tsai, Hsiao-Pei
   Hou, Po-Hsun
   Mao, Frank-Chiahung
   Chang, Chia-Chia
   Yang, Wei-Cheng
   Wu, Ching-Feng
   Liao, Huei-Jyuan
   Lin, Tzu-Chun
   Chou, Lan-Szu
   Hsiao, Li-Wei
   Chang, Geng-Ruei
TI Risperidone Exacerbates Glucose Intolerance, Nonalcoholic Fatty Liver
   Disease, and Renal Impairment in Obese Mice
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE fatty liver disease; glucose intolerance; obesity; renal impairment;
   risperidone
ID GROWTH-FACTOR 21; OXIDATIVE STRESS; ATYPICAL ANTIPSYCHOTICS; METABOLIC
   SYNDROME; INCREASED RISK; KIDNEY INJURY; WEIGHT-GAIN; BODY-WEIGHT;
   PPAR-GAMMA; ACID
AB Risperidone, a second-generation antipsychotic drug used for schizophrenia treatment with less-severe side effects, has recently been applied in major depressive disorder treatment. The mechanism underlying risperidone-associated metabolic disturbances and liver and renal adverse effects warrants further exploration. This research explores how risperidone influences weight, glucose homeostasis, fatty liver scores, liver damage, and renal impairment in high-fat diet (HFD)-administered C57BL6/J mice. Compared with HFD control mice, risperidone-treated obese mice exhibited increases in body, liver, kidney, and retroperitoneal and epididymal fat pad weights, daily food efficiency, serum triglyceride, blood urea nitrogen, creatinine, hepatic triglyceride, and aspartate aminotransferase, and alanine aminotransferase levels, and hepatic fatty acid regulation marker expression. They also exhibited increased insulin resistance and glucose intolerance but decreased serum insulin levels, Akt phosphorylation, and glucose transporter 4 expression. Moreover, their fatty liver score and liver damage demonstrated considerable increases, corresponding to increases in sterol regulatory element-binding protein 1 mRNA, fatty acid-binding protein 4 mRNA, and patatin-like phospholipid domain containing protein 3 expression. Finally, these mice demonstrated renal impairment, associated with decreases in glutathione peroxidase, superoxide dismutase, and catalase levels. In conclusion, long-term administration of risperidone may exacerbate diabetes syndrome, nonalcoholic fatty liver disease, and kidney injury.
C1 [Tsai, Hsiao-Pei; Chou, Lan-Szu; Chang, Geng-Ruei] Natl Chiayi Univ, PhD Program Agr Sci, 300 Syuefu Rd, Chiayi 60004, Taiwan.
   [Tsai, Hsiao-Pei; Chang, Geng-Ruei] Natl Chiayi Univ, Vet Teaching Hosp, 580 Xinmin Rd, Chiayi 60054, Taiwan.
   [Hou, Po-Hsun] Taichung Vet Gen Hosp, Dept Psychiat, 4 Sect,1650 Taiwan Blvd, Taichung 40705, Taiwan.
   [Hou, Po-Hsun] Natl Yang Ming Univ, Fac Med, 2 Sect,155 Linong St, Taipei 11221, Taiwan.
   [Mao, Frank-Chiahung] Natl Chung Hsing Univ, Dept Vet Med, 250 Kuo Kuang Rd, Taichung 40227, Taiwan.
   [Chang, Chia-Chia] Council Agr, Anim Hlth Res Inst, Anim Drugs Inspect Branch, 21 Muchang, Zhunan Township 35054, Miaoli County, Taiwan.
   [Yang, Wei-Cheng] Natl Taiwan Univ, Sch Vet Med, 4 Sect,1 Roosevelt Rd, Taipei 10617, Taiwan.
   [Wu, Ching-Feng; Lin, Tzu-Chun] Chang Gung Univ, Chang Gung Mem Hosp, Div Thorac & Cardiovasc Surg, Dept Surg, 5 Fuxing St, Taoyuan 33305, Taiwan.
   [Liao, Huei-Jyuan; Chang, Geng-Ruei] Natl Chiayi Univ, Dept Vet Med, 580 Xinmin Rd, Chiayi 60054, Taiwan.
   [Chou, Lan-Szu] Natl Chiayi Univ, Dept BioAgr Sci, 300 Syuefu Rd, Chiayi 60004, Taiwan.
   [Hsiao, Li-Wei] Chang Bing Show Chwan Mem Hosp, Div Endocrinol & Metab, 6 Lugong Rd, Changhua 50544, Taiwan.
C3 National Chiayi University; National Chiayi University; Taichung
   Veterans General Hospital; National Yang Ming Chiao Tung University;
   National Chung Hsing University; National Taiwan University; Chang Gung
   University; Chang Gung Memorial Hospital; National Chiayi University;
   Chang Bing Show Chwan Memorial Hospital
RP Chou, LS; Chang, GR (corresponding author), Natl Chiayi Univ, PhD Program Agr Sci, 300 Syuefu Rd, Chiayi 60004, Taiwan.; Chang, GR (corresponding author), Natl Chiayi Univ, Vet Teaching Hosp, 580 Xinmin Rd, Chiayi 60054, Taiwan.; Chang, GR (corresponding author), Natl Chiayi Univ, Dept Vet Med, 580 Xinmin Rd, Chiayi 60054, Taiwan.; Chou, LS (corresponding author), Natl Chiayi Univ, Dept BioAgr Sci, 300 Syuefu Rd, Chiayi 60004, Taiwan.; Hsiao, LW (corresponding author), Chang Bing Show Chwan Mem Hosp, Div Endocrinol & Metab, 6 Lugong Rd, Changhua 50544, Taiwan.
EM tsaibelle@mail.ncyu.edu.tw; peterhopo2@yahoo.com.tw; fcmao@nchu.edu.tw;
   bccchia@mail.nvri.gov.tw; yangweicheng@ntu.edu.tw; maple.bt88@gmail.com;
   pipi324615@gmail.com; lin890090@gmail.com; choulb@mail.ncyu.edu.tw;
   kmccenor@gmail.com; grchang@mail.ncyu.edu.tw
OI Chang, Geng-Ruei/0000-0003-0577-3339; Wu, Ching Feng/0000-0001-9618-3937
FU Chang Bing Show Chwan Memorial Hospital (Taiwan) [BRD108046]; National
   Chiayi University (Taiwan) [107A3-146, 107A3-155, 108A3021]; Chang Gung
   Memorial Hospital (Taiwan) [CMRPG5J0191]; Taichung Veterans General
   Hospital (Taiwan); National Chung-Hsing University (Taiwan)
   [TCVGH-NCHU-1097612]
FX This study was supported in part by Grant BRD108046 from the Chang Bing
   Show Chwan Memorial Hospital (Taiwan), National Chiayi University
   (Taiwan; 107A3-146, 107A3-155, and 108A3021), Chang Gung Memorial
   Hospital (Taiwan; CMRPG5J0191), Taichung Veterans General Hospital
   (Taiwan), and National Chung-Hsing University (Taiwan;
   TCVGH-NCHU-1097612).
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NR 75
TC 24
Z9 24
U1 0
U2 13
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD JAN
PY 2021
VL 22
IS 1
AR 409
DI 10.3390/ijms22010409
PG 21
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA PQ0CC
UT WOS:000606218300001
PM 33401717
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Packer, M
AF Packer, Milton
TI Characterization, Pathogenesis, and Clinical Implications of
   Inflammation-Related Atrial Myopathy as an Important Cause of Atrial
   Fibrillation
SO JOURNAL OF THE AMERICAN HEART ASSOCIATION
LA English
DT Review
DE atrial fibrillation; atrial myopathy; stroke
ID EPICARDIAL ADIPOSE-TISSUE; C-REACTIVE PROTEIN; TYPE-2 DIABETES-MELLITUS;
   CHA(2)DS(2)-VASC SCORE; METABOLIC SYNDROME; HEART-FAILURE; SUBCLINICAL
   HYPOTHYROIDISM; CEREBROVASCULAR-DISEASE; THROMBOEMBOLIC EVENTS; PRIMARY
   ALDOSTERONISM
AB Historically, atrial fibrillation has been observed in clinical settings of prolonged hemodynamic stress, eg, hypertension and valvular heart disease. However, recently, the most prominent precedents to atrial fibrillation are metabolic diseases that are associated with adipose tissue inflammation (ie, obesity and diabetes mellitus) and systemic inflammatory disorders (ie, rheumatoid arthritis and psoriasis). These patients typically have little evidence of left ventricular hypertrophy or dilatation; instead, imaging reveals abnormalities of the structure or function of the atria, particularly the left atrium, indicative of an atrial myopathy. The left atrium is enlarged, fibrotic and noncompliant, potentially because the predisposing disorder leads to an expansion of epicardial adipose tissue, which transmits proinflammatory mediators to the underlying left atrium. The development of an atrial myopathy not only leads to atrial fibrillation, but also contributes to pulmonary venous hypertension and systemic thromboembolism. These mechanisms explain why disorders of systemic or adipose tissue inflammation are accompanied an increased risk of atrial fibrillation, abnormalities of left atrium geometry and an enhanced risk of stroke. The risk of stroke exceeds that predicted by conventional cardiovascular risk factors or thromboembolism risk scores used to guide the use of anticoagulation, but it is strongly linked to clinical evidence and biomarkers of systemic inflammation.
C1 [Packer, Milton] Baylor Univ, Med Ctr, Baylor Heart & Vasc Inst, Dallas, TX USA.
   [Packer, Milton] Imperial Coll, London, England.
C3 Baylor University; Baylor University Medical Center; Imperial College
   London
RP Packer, M (corresponding author), Baylor Heart & Vasc Inst, 621 N Hall St, Dallas, TX 75226 USA.
EM milton.packer@baylorhealth.edu
RI Packer, Milton/ACB-4196-2022
OI Packer, Milton/0000-0003-1828-2387
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   2019, BRAIN STIMUL MAR, V12
NR 100
TC 64
Z9 65
U1 0
U2 9
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2047-9980
J9 J AM HEART ASSOC
JI J. Am. Heart Assoc.
PD APR 9
PY 2020
VL 9
IS 7
DI 10.1161/JAHA.119.015343
PG 9
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA LF7LD
UT WOS:000527597700049
PM 32242478
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Câmara, AB
   Brandao, IA
AF Camara, Alice Barros
   Brandao, Igor Augusto
TI Study of the relationship between vitamin D deficiency, sunlight
   incidence and skeletal/extra skeletal diseases
SO ACTA SCIENTIARUM-HEALTH SCIENCES
LA English
DT Article
DE hypercholesterolemy; hypertriglyceridemia; cancer; diabetes;
   hepatobiliary diseases; urinary system diseases
ID D-RECEPTOR; METABOLIC SYNDROME; OXIDATIVE STRESS; LIVER-DISEASE;
   HYPERCHOLESTEROLEMIA; ASSOCIATION; ACTIVATION
AB It is estimated that more than 1 billion people worldwide have vitamin D insufficiency or deficiency. Vitamin D participates in bone mineralization, and is therefore important in osteoporosis, osteomalacia and rickets prevention. However, vitamin D deficiency could also be associated with several other pathologies. The present study aimed to investigate the relationships between vitamin D deficiency and vitamin D deficiency-related disorders in patients. In addition, this study aims to verify if countries with low solar incidence have higher extraskeletal disease death rates when compared to countries with high solar incidence. The vitamin D concentrations were obtained from the Heart Hospital database (Natal/Brazil). The relationship between solar incidence and death rate for vitamin D deficiency-related disorders was verified. Death rate data were extracted from the 'World Life Expectancy' repository and data about solar incidence were obtained from NASA's Surface Meteorology and Solar Energy project. These data were statistically processed with IBM SPSS v23.0 software and R programming language. Our results showed that patients with vitamin D insufficiency/deficiency showed significantly more bone diseases, thyroid diseases, hypercholesterolemy, hypertriglyceridemia, cancers, diabetes, hepatobiliary diseases, and urinary system diseases. Moreover, countries with high solar incidence have low cancer and multiple sclerosis death rates. This work suggests the participation of vitamin D and sunlight incidence in several diseases.
C1 [Camara, Alice Barros] Univ Fed Rio Grande do Norte, Ctr Biociencia, Dept Biociencia & Farmacol, Ave Senador Salgado Filho,3000, BR-59064741 Natal, RN, Brazil.
   [Brandao, Igor Augusto] Univ Fed Rio Grande do Norte, Nucleo Multidisciplinar Bioinformat, Natal, RN, Brazil.
C3 Universidade Federal do Rio Grande do Norte; Universidade Federal do Rio
   Grande do Norte
RP Câmara, AB (corresponding author), Univ Fed Rio Grande do Norte, Ctr Biociencia, Dept Biociencia & Farmacol, Ave Senador Salgado Filho,3000, BR-59064741 Natal, RN, Brazil.
EM alicecamara@hotmail.com
RI Camara, Alice/NAZ-1254-2025
OI Augusto Brandao, Igor/0000-0002-1823-5014
FU governmental Brazilian agency National Council for Scientific and
   Technological Development (CNPq, Portuguese: Conselho Nacional de
   Desenvolvimento Cientifico e Tecnologico) [444856/2014-5]; governmental
   Brazilian agency Coordination for the Improvement of Higher Education
   Personnel (CAPES, Portuguese: Coordenacao de Aperfeicoamento Pessoal de
   Nivel Superior)
FX This work has been financed by the governmental Brazilian agency
   National Council for Scientific and Technological Development (CNPq,
   Portuguese: Conselho Nacional de Desenvolvimento Cientifico e
   Tecnologico), grant 444856/2014-5. The scholarships were financed by
   governmental Brazilian agency Coordination for the Improvement of Higher
   Education Personnel (CAPES, Portuguese: Coordenacao de Aperfeicoamento
   Pessoal de Nivel Superior).
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NR 49
TC 0
Z9 0
U1 0
U2 1
PU UNIV ESTADUAL MARINGA, PRO-REITORIA PESQUISA POS-GRADUACAO
PI MARINGA
PA AV. COLOMBO, 5790, DIVISAO DE DIVULGACAO CIENTIFICA, MARINGA, PR
   87020-900, BRAZIL
SN 1679-9291
EI 1807-8648
J9 ACTA SCI-HEALTH SCI
JI Acta Sci.-Health Sci.
PY 2020
VL 42
AR e50599
DI 10.4025/actascihealthsci.v42i1.50599
PG 13
WC Public, Environmental & Occupational Health
WE Emerging Sources Citation Index (ESCI)
SC Public, Environmental & Occupational Health
GA LF8NX
UT WOS:000527672500001
OA Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Guillén, C
   Benito, M
AF Guillen, Carlos
   Benito, Manuel
TI mTORC1 Overactivation as a Key Aging Factor in the Progression to Type 2
   Diabetes Mellitus
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Review
DE T2DM; autophagy; amylin; mitophagy; mTORC1; TSC2
ID BETA-CELL MASS; ENDOPLASMIC-RETICULUM STRESS; GROWTH-FACTOR DEPRIVATION;
   LIFE-SPAN; RAG GTPASES; TSC1-TSC2 COMPLEX; MAMMALIAN TARGET; GENETIC
   PATHWAYS; EXTENDS LIFE; GAP ACTIVITY
AB Type 2 Diabetes Mellitus (T2DM), a worldwide epidemics, is a progressive disease initially developing an insulin resistant state, with manifest pancreatic beta islet overwork and hyperinsulinemia. As the disease progresses, pancreatic beta cells are overwhelmed and fails in their capacity to compensate insulin resistance. In addition, it is usually associated with other metabolic diseases such as hyperlipidemia, obesity and the metabolic syndrome. During the progression to T2DM there is a chronic activation of mTORC1 signaling pathway, which induces aging and acts as an endogenous inhibitor of autophagy. The complex 1 of mTOR (mTORC1) controls cell proliferation, cell growth as well as metabolism in a variety of cell types through a complex signaling network. Autophagy is involved in the recycling of cellular components for energy generation under nutrient deprivation, and serves as a complementary degradation system to the ubiquitin-proteasome pathway. Autophagy represents a protective mechanism for different cell types, including pancreatic beta cells, and potentiates beta cell survival across the progression to T2DM. Here, we focus our attention on the chronic overactivation of mTORC1 signaling pathway in beta islets from prediabetics patients, making these cells more prone to trigger apoptosis upon several cellular stressors and allowing the progression from prediabetes to type 2 diabetes status.
C1 [Guillen, Carlos; Benito, Manuel] Univ Complutense Madrid, Fac Pharm, Dept Biochem & Mol Biol, Madrid, Spain.
   [Guillen, Carlos; Benito, Manuel] Inst Salud Carlos III, Spanish Biomed Res Ctr Diabet & Associated Metab, Madrid, Spain.
C3 Complutense University of Madrid; Instituto de Salud Carlos III
RP Guillén, C (corresponding author), Univ Complutense Madrid, Fac Pharm, Dept Biochem & Mol Biol, Madrid, Spain.; Guillén, C (corresponding author), Inst Salud Carlos III, Spanish Biomed Res Ctr Diabet & Associated Metab, Madrid, Spain.
EM cguillen@ucm.es
RI Benito, Melissa/IAP-0513-2023; Guillen, Carlos/J-9728-2014
OI Guillen, Carlos/0000-0002-9370-6314; Guillen, Carlos/0000-0003-2717-1929
FU M.C.T., Spain [SAF2017-82133R]
FX Our research it is supported by grant SAF2017-82133R from M.C.T., Spain.
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NR 96
TC 63
Z9 65
U1 0
U2 13
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD OCT 16
PY 2018
VL 9
AR 621
DI 10.3389/fendo.2018.00621
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA GX0FV
UT WOS:000447386500001
PM 30386301
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Huang, WC
   Liao, PC
   Huang, CH
   Hu, S
   Huang, SC
   Wu, SJ
AF Huang, Wen-Chung
   Liao, Po-Chen
   Huang, Chun-Hsun
   Hu, Sindy
   Huang, Shih-Chun
   Wu, Shu-Ju
TI Osthole attenuates lipid accumulation, regulates the expression of
   inflammatory mediators, and increases antioxidants in FL83B cells
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Article
DE Nonalcoholic fatty liver disease; p38 MAPK; NF-kappa B; Antioxidant;
   Osthole
ID FATTY LIVER-DISEASE; METABOLIC SYNDROME; PATHOGENESIS; INVOLVEMENT
AB Osthole is found in Cnidium monnieri (L.) and has anti-inflammatory and anti-oxidative properties. It also inhibits the proliferation of hepatocellular carcinoma cells. This study aimed to evaluate the osthole suppressive nonalcoholic fatty liver disease effects in oleic acid (OA)-induced hepatic steatosis and if it can modulate inflammatory responses and oxidative stress. FL83B cells were pretreated with OA (250 mu M) for 24 h, and then added different concentrations of osthole (3-100 mu M) for 24 h. Subsequently, lipolysis and transcription factors of adipogenesis and phosphorylation of AMP-activated protein kinase proteins were measured. In addition, cells with OA-induced steatosis were H2O2-stimulated, and then incubated with osthole to evaluated if it could suppress its progression to steatohepatitis. Osthole significantly enhanced glycerol release and lipolysis protein expression. Osthole also promoted phosphorylation of AMP-activated protein kinases and increased the activity of triglyceride lipase and hormone-sensitive lipase. Osthole suppressed the nuclear transcription factor kappa-B and the p38 mitogen-activated protein kinase pathway, and decreased the malondialdehyde concentration in FL83B cells with OA-induced steatosis that were treated with H2O2. These results suggest that osthole might suppress nonalcoholic fatty liver disease by decreasing lipid accumulation, and through its anti-oxidative and anti-inflammatory effects via blocked NF-kappa B and MAPK signaling pathways. (C) 2017 Elsevier Masson SAS. All rights reserved.
C1 [Huang, Wen-Chung] Chang Gung Univ Sci & Technol, Coll Human Ecol, Res Ctr Chinese Herbal Med, Grad Inst Hlth Ind Technol,Res Ctr Ind Human Ecol, 261,Wenhua 1st Rd, Taoyuan 33303, Taiwan.
   [Huang, Wen-Chung; Liao, Po-Chen; Huang, Shih-Chun; Wu, Shu-Ju] Chang Gung Univ Sci & Technol, Coll Human Ecol, Res Ctr Food & Cosmet Safety, Dept Nutr & Hlth Sci, 261,Wenhua 1st Rd, Taoyuan 33303, Taiwan.
   [Huang, Wen-Chung; Liao, Po-Chen; Huang, Shih-Chun; Wu, Shu-Ju] Chang Gung Univ Sci & Technol, Coll Human Ecol, Res Ctr Chinese Herbal Med, 261,Wenhua 1st Rd, Taoyuan 33303, Taiwan.
   [Liao, Po-Chen] Natl Yang Ming Univ, Inst Oral Biol, Taipei, Taiwan.
   [Huang, Chun-Hsun] Chang Gung Univ Sci & Technol, Dept Cosmet Sci, 261,Wenhua 1st Rd, Taoyuan 33303, Taiwan.
   [Huang, Chun-Hsun; Hu, Sindy; Wu, Shu-Ju] Chang Gung Mem Hosp, Dept Dermatol, Aesthet Med Ctr, Taoyuan 33303, Taiwan.
C3 Chang Gung University of Science & Technology; Chang Gung University of
   Science & Technology; Chang Gung University of Science & Technology;
   National Yang Ming Chiao Tung University; Chang Gung University of
   Science & Technology; Chang Gung Memorial Hospital
RP Wu, SJ (corresponding author), Chang Gung Univ Sci & Technol, Dept Nutr & Hlth Sci, 261,Wenhua 1st Rd, Taoyuan 33303, Taiwan.
EM sjwu@gw.cgust.edu.tw
RI Huang, Hsin-Chun/AAJ-5872-2020
FU Chang Gung Memorial Hospital [CMRPF1F0121]; Ministry of Science and
   Technology in Taiwan [MOST 105-2320-B-255-004-]; Chang Gung University
   of Science and Technology [EZRPF3F0141]
FX This study was supported in part by grants from the Chang Gung Memorial
   Hospital (CMRPF1F0121) and Ministry of Science and Technology in Taiwan
   (MOST 105-2320-B-255-004-), and Chang Gung University of Science and
   Technology (EZRPF3F0141).
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NR 37
TC 33
Z9 36
U1 1
U2 13
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD JUL
PY 2017
VL 91
BP 78
EP 87
DI 10.1016/j.biopha.2017.04.051
PG 10
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA FB8PB
UT WOS:000406399900010
PM 28448873
DA 2025-06-11
ER

PT J
AU Zeng, H
   Vaka, VR
   He, XC
   Booz, GW
   Chen, JX
AF Zeng, Heng
   Vaka, Venkata Ramana
   He, Xiaochen
   Booz, George W.
   Chen, Jian-Xiong
TI High-fat diet induces cardiac remodelling and dysfunction: assessment of
   the role played by SIRT3 loss
SO JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
LA English
DT Article
DE Sirtuin 3; HIF-1; HIF-2; High-fat diet; reactive oxygen species; cardiac
   function
ID MEDIATED CELL-DEATH; METABOLIC SYNDROME; CARDIOVASCULAR-DISEASE; LYSINE
   ACETYLATION; OXIDATIVE STRESS; OBESITY; HEART; GENE; HOMOLOG;
   CARDIOMYOCYTES
AB Mitochondrial dysfunction plays an important role in obesity-induced cardiac impairment. SIRT3 is a mitochondrial protein associated with increased human life span and metabolism. This study investigated the functional role of SIRT3 in obesity-induced cardiac dysfunction. Wild-type (WT) and SIRT3 knockout (KO) mice were fed a normal diet (ND) or high-fat diet (HFD) for 16weeks. Body weight, fasting glucose levels, reactive oxygen species (ROS) levels, myocardial capillary density, cardiac function and expression of hypoxia-inducible factor (HIF)-1/-2 were assessed. HFD resulted in a significant reduction in SIRT3 expression in the heart. Both HFD and SIRT3 KO mice showed increased ROS formation, impaired HIF signalling and reduced capillary density in the heart. HFD induced cardiac hypertrophy and impaired cardiac function. SIRT3 KO mice fed HFD showed greater ROS production and a further reduction in cardiac function compared to SIRT3 KO mice on ND. Thus, the adverse effects of HFD on cardiac function were not attributable to SIRT3 loss alone. However, HFD did not further reduce capillary density in SIRT3 KO hearts, implicating SIRT3 loss in HFD-induced capillary rarefaction. Our study demonstrates the importance of SIRT3 in preserving heart function and capillary density in the setting of obesity. Thus, SIRT3 may be a potential therapeutic target for obesity-induced heart failure.
C1 [Zeng, Heng; Vaka, Venkata Ramana; He, Xiaochen; Booz, George W.; Chen, Jian-Xiong] Univ Mississippi, Med Ctr, Sch Med, Dept Pharmacol & Toxicol, Jackson, MS 39216 USA.
C3 University of Mississippi; University of Mississippi Medical Center
RP Chen, JX (corresponding author), Univ Mississippi, Med Ctr, Sch Med, Dept Pharmacol & Toxicol, Jackson, MS 39216 USA.
EM jchen3@umc.edu
RI He, Xiaochen/ABA-8102-2021; Vaka, Ramana/GPK-2317-2022
OI Vaka, Ramana/0000-0003-1889-3532; He, Xiaochen/0000-0002-8266-5895
FU NIH [HL102042]
FX This study was supported by grants from NIH grant HL102042 to J.X. Chen.
   We thank Dr. XW Hou for assisting us by performing the echocardiography.
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NR 27
TC 99
Z9 104
U1 0
U2 19
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
EI 1582-4934
J9 J CELL MOL MED
JI J. Cell. Mol. Med.
PD AUG
PY 2015
VL 19
IS 8
BP 1847
EP 1856
DI 10.1111/jcmm.12556
PG 10
WC Cell Biology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Research & Experimental Medicine
GA CO1OO
UT WOS:000358925100009
PM 25782072
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Linhart, KB
   Glassen, K
   Peccerella, T
   Waldherr, R
   Linhart, H
   Bartsch, H
   Seitz, HK
AF Linhart, Kirsten-Berit
   Glassen, Katharina
   Peccerella, Teresa
   Waldherr, Rudiger
   Linhart, Heinz
   Bartsch, Helmut
   Seitz, Helmut
TI The generation of carcinogenic etheno-DNA adducts in the liver of
   patients with nonalcoholic fatty liver disease
SO HEPATOBILIARY SURGERY AND NUTRITION
LA English
DT Article
DE Nonalcoholic fatty liver disease (NAFLD); etheno-DNA adducts;
   hepatocellular carcinoma (HCC)
ID HEPATIC CYTOCHROME-P450 2E1; VINYL-CHLORIDE; METABOLIC SYNDROME;
   IMMUNOHISTOCHEMICAL DETECTION; INSULIN-RESISTANCE; OXIDATIVE STRESS;
   STEATOHEPATITIS; ALCOHOL; CANCER; CELLS
AB Background: Nonalcoholic fatty liver disease (NAFLD), in particular its more aggressive form nonalcoholic steatohepatitis (NASH) is increasingly observed as a cause of end stage liver disease and hepatocellular carcinoma (HCC). Reactive oxygen species (ROS) are an important factor in the pathogenesis of HCC. ROS can react with polyunsaturated fatty acids derived from membrane phospholipids resulting in the production of reactive aldehydes as lipid oxidation (LPO) byproducts, such as 4-hydroxynonenal (4 HNE). 4 HNE can react with DNA to form mutagenic exocyclic etheno-DNA adducts. ROS is induced by inflammatory processes, but also by induction of cytochrome P450 2E1 (CYP2E1), as seen with chronic alcohol consumption.
   Methods: Immunohistochemical detection of CYP2E1, 4 HNE and hepatic exocyclic etheno-DNA adducts was performed on liver sections from 39 patients with NFLD. Spearman rank correlation was calculated to examine possible correlations.
   Results: Exocyclic etheno-DNA adducts were detected and correlated significantly with 4 HNE, but not with CYP2E1.
   Conclusions: This is the first description of highly carcinogenic exocyclic etheno-DNA adducts in NAFLD patients. We could show that exocyclic etheno-DNA adducts significantly correlated with lipid peroxidation product 4 HNE, but not with CYP2E1, implying that in NAFLD ROS generation with consecutive DNA damage is rather inflammation driven through various cytokines than by induction of CYP2E1.
C1 [Linhart, Kirsten-Berit; Glassen, Katharina; Peccerella, Teresa; Waldherr, Rudiger; Linhart, Heinz; Seitz, Helmut] Heidelberg Univ, Alcohol Res Ctr, Heidelberg, Germany.
   [Linhart, Kirsten-Berit; Glassen, Katharina; Peccerella, Teresa; Waldherr, Rudiger; Linhart, Heinz; Seitz, Helmut] Salem Med Ctr, Dept Med Gastroenterol & Hepatol, Heidelberg, Germany.
   [Bartsch, Helmut] Germany Canc Res Ctr DKFZ, Div Toxicol & Canc Risk Factors, Heidelberg, Germany.
C3 Ruprecht Karls University Heidelberg; Helmholtz Association; German
   Cancer Research Center (DKFZ)
RP Seitz, HK (corresponding author), Heidelberg Univ, Salem Med Ctr, Dept Med, Gastroenterol & Alcohol Res,Med, Heidelberg, Germany.
EM helmut_karl.seitz@urz.uni-heidelberg.de
OI Peccerella, Teresa/0000-0001-5520-0243; Glassen,
   Ronald/0000-0003-3195-5718
FU Dietmar Hopp Foundation
FX This work was supported by the Dietmar Hopp Foundation.
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NR 38
TC 26
Z9 31
U1 0
U2 7
PU AME PUBLISHING COMPANY
PI SHATIN
PA FLAT-RM C 16F, KINGS WING PLAZA 1, NO 3 KWAN ST, SHATIN, HONG KONG
   00000, PEOPLES R CHINA
SN 2304-3881
EI 2304-389X
J9 HEPATOBIL SURG NUTR
JI Hepatobil. Surg. Nutr.
PD APR
PY 2015
VL 4
IS 2
BP 117
EP 123
DI 10.3978/j.issn.2304-3881.2015.01.14
PN 1
PG 7
WC Gastroenterology & Hepatology; Nutrition & Dietetics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Nutrition & Dietetics; Surgery
GA V70OT
UT WOS:000211516600005
PM 26005678
DA 2025-06-11
ER

PT J
AU Hynes, AMJ
   Rouvinen-Watt, K
AF Hynes, Amber M. J.
   Rouvinen-Watt, Kirsti
TI Monitoring blood glucose levels in female mink during the reproductive
   cycle: 2. Effects of short-term fish oil, chromium picolinate, and
   acetylsalicylic acid supplementation during late lactation
SO CANADIAN JOURNAL OF VETERINARY RESEARCH-REVUE CANADIENNE DE RECHERCHE
   VETERINAIRE
LA English
DT Article
ID TYPE-2 DIABETES-MELLITUS; OXIDATIVE STRESS; INSULIN-RESISTANCE; NURSING
   SICKNESS; MUSTELA-VISON; BODY-WEIGHT; FATTY-ACIDS; ASPIRIN; METABOLISM;
   HYPERGLYCEMIA
AB Mink nursing sickness is a metabolic disorder characterized by hyperglycemia that is similar to the metabolic syndrome associated with type 2, or non-insulin-dependent, diabetes mellitus. This research studied the effects of short-term administration of antidiabetic supplements on the blood glucose concentration in female mink during late lactation. Female mink that had blood glucose levels < 5.5 mmol/L (normoglycemic [NG]) or >= 5.5 mmol/L (hyperglycemic [HG]) early in lactation were given daily supplements of various combinations of herring oil (HerO, 3% in diet), chromium picolinate (CrPic, 200 mu g), and acetylsalicylic acid (ASA, 100 mg) for 1 wk starting at day 21 post partum. In the NG mink, most of the treatments did not significantly change the blood glucose concentration from day 28 to 42 post partum. However, treatment with ASA alone and treatment with the combination HerO-CrPic-ASA elevated the blood glucose levels when compared with those of the control group, which had received just the basal diet. In the HG mink, all treatment combinations except CrPic alone and ASA alone, reduced the blood glucose concentration. Thus, in lactating mink with hyperglycemia, the blood glucose concentration may be effectively lowered by dietary antidiabetic supplementation; however, because hyperglycemia also occurs before nursing, preventive measures are recommended throughout the year.
C1 Nova Scotia Agr Coll, Dept Anim & Plant Sci, Truro, NS B2N 5E3, Canada.
   Nova Scotia Agr Coll, Canadian Ctr Anim Res, Truro, NS B2N 5E3, Canada.
C3 Dalhousie University; Dalhousie University
RP Rouvinen-Watt, K (corresponding author), Nova Scotia Agr Coll, Dept Anim & Plant Sci, POB 550, Truro, NS B2N 5E3, Canada.
EM krouvinen@nsac.ca
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NR 52
TC 7
Z9 12
U1 0
U2 6
PU CANADIAN VET MED ASSOC
PI OTTAWA
PA 339 BOOTH ST, OTTAWA, ONTARIO K1R 7K1, CANADA
SN 0830-9000
J9 CAN J VET RES
JI Can. J. Vet. Res.-Rev. Can. Rech. Vet.
PD OCT
PY 2007
VL 71
IS 4
BP 249
EP 255
PG 7
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA 212CJ
UT WOS:000249570900002
PM 17955898
DA 2025-06-11
ER

PT J
AU Franconi, F
   Loizzo, A
   Ghirlanda, G
   Seghieri, G
AF Franconi, F
   Loizzo, A
   Ghirlanda, G
   Seghieri, G
TI Taurine supplementation and diabetes mellitus
SO CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE
LA English
DT Article
DE insulin-dependent diabetes mellitus; insulin-independent diabetes
   mellitus; insulin resistance; programming; taurine supplementation
ID OXIDATIVE STRESS; METABOLIC SYNDROME; PLATELET TAURINE; MESANGIAL CELLS;
   GROWTH-FACTOR; UP-REGULATION; HIGH GLUCOSE; BETA-CELLS; AMINO-ACID;
   FATTY RAT
AB Purpose of review
   Taurine is a semi-essential sulphur amino acid derived from methionine and cysteine metabolism. It has been evaluated either in experimental or clinical type 1 and 2 diabetes mellitus and insulin resistance. One form of experiment has included the possibility that perinatal taurine administration could prevent diabetes mellitus and/or insulin resistance.
   Recent findings
   Experimental data suggest strongly that taurine could have beneficial effects in type 1 diabetes mellitus, and could generally reduce organ lipid peroxidation and plasma lipids. Interestingly, retina, lens and nerves seem to respond better to taurine than other organs such as kidneys. It has been shown in some experimental models that in type 2 diabetes mellitus and insulin resistance there is alteration in taurine homeostasis. Taurine could prevent the onset of diabetes mellitus in NOD mice and postnatal taurine modifies the glucose-loading curves in adults. However, the clinical studies are too small and too short to have any real significance.
   Summary
   Further experimental and clinical studies are required to evaluate taurine's possible therapeutic potential. Careful attention has to be paid in the selection of animal species, in standardization of taurine concentrations and patient selection. Moreover, care must also be given to the metabolic state, presence of complications, duration of supplementations and selection of the right end-points.
C1 Univ Sassari, Dept Pharmacol, I-07100 Sassari, Italy.
   Univ Sassari, Ctr Biotechnol Dev & Biodivers Res, I-07100 Sassari, Italy.
   Natl Inst Hlth, Rome, Italy.
   Catholic Univ, Dept Internal & Geriatr Med, Rome, Italy.
   Pistoia Hosp, Pistoia, Italy.
C3 University of Sassari; University of Sassari; Istituto Superiore di
   Sanita (ISS); Catholic University of the Sacred Heart; IRCCS Policlinico
   Gemelli
RP Univ Sassari, Dept Pharmacol, Via Muroni 23A, I-07100 Sassari, Italy.
EM franconi@uniss.it
RI SEGHIERI, GIUSEPPE/AAF-1161-2019
OI Seghieri, Giuseppe/0000-0002-7599-4455
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NR 64
TC 80
Z9 88
U1 0
U2 20
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1363-1950
EI 1473-6519
J9 CURR OPIN CLIN NUTR
JI Curr. Opin. Clin. Nutr. Metab. Care
PD JAN
PY 2006
VL 9
IS 1
BP 32
EP 36
DI 10.1097/01.mco.0000196141.65362.46
PG 5
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 015KT
UT WOS:000235551000008
PM 16444816
DA 2025-06-11
ER

PT J
AU Rajpoot, A
   Sharma, V
AF Rajpoot, Anjali
   Sharma, Veena
TI Bridging Cancer and Cardiovascular Health: A Comprehensive Review of
   Cardiotoxicity in Modern Oncology
SO HEART AND MIND
LA English
DT Review
DE Anthracyclines; cancer; cardio-oncology; cardiotoxicity; cardiovascular
   disease
ID CARDIO-ONCOLOGY; ENDOTHELIAL FUNCTION; CONSENSUS STATEMENT; METABOLIC
   SYNDROME; PHYSICAL-ACTIVITY; OXIDATIVE STRESS; POSITION PAPER;
   BETA-BLOCKERS; RISK; CHEMOTHERAPY
AB As survival rates for cancer patients improve due to advancements in treatment modalities, there is an increasing prevalence of cardiovascular complications, necessitating a comprehensive understanding of this intersection. This review aims to elucidate the intricate relationship between cancer and cardiovascular disease, highlighting the growing concern of cardiovascular toxicity associated with cancer therapies. It explores various cancer treatments, including chemotherapy, targeted therapies, and radiation, and their associated cardiovascular risks, such as heart failure and ischemic heart disease. In addition, it discusses the importance of proactive cardiovascular risk assessments and ongoing monitoring in cancer patients to mitigate adverse outcomes. Strategies for prevention and management, including lifestyle modifications and pharmacologic interventions, are also examined to support the cardiovascular health of cancer survivors. Unlike previous reviews, this work integrates insights from multidisciplinary collaborations, emphasizing underexplored mechanisms of cardiovascular toxicity and the role of innovative monitoring tools. It also highlights emerging therapeutic strategies tailored to mitigate these risks, providing a forward-looking perspective in this critical area of research. The need for a collaborative method that includes oncologists, cardiologists, and primary care providers is emphasized to ensure integrated care that addresses both cancer treatment and cardiovascular health. This review serves as a critical resource for healthcare professionals seeking to improve the long-term outcomes for cancer survivors by recognizing and managing cardiovascular risks.
C1 [Rajpoot, Anjali; Sharma, Veena] Banasthali Vidyapith, Dept Biosci & Biotechnol, Jaipur 304022, Rajasthan, India.
C3 Banasthali Vidyapith
RP Rajpoot, A (corresponding author), Banasthali Vidyapith, Dept Biosci & Biotechnol, Jaipur 304022, Rajasthan, India.
EM anjali0110rajput@gmail.com
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NR 147
TC 0
Z9 0
U1 0
U2 0
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, Maharashtra, INDIA
SN 2468-6476
EI 2468-6484
J9 HEART MIND
JI Heart Mind
PD MAR-APR
PY 2025
VL 9
IS 2
BP 115
EP 135
DI 10.4103/hm.HM-D-24-00148
PG 21
WC Cardiac & Cardiovascular Systems; Psychiatry
WE Emerging Sources Citation Index (ESCI)
SC Cardiovascular System & Cardiology; Psychiatry
GA 1YS0R
UT WOS:001476805300002
DA 2025-06-11
ER

PT J
AU Somabattini, RA
   Sherin, S
   Siva, B
   Chowdhury, N
   Nanjappan, SK
AF Somabattini, Ravi Adinarayan
   Sherin, Sahla
   Siva, Bhukya
   Chowdhury, Neelanjan
   Nanjappan, Satheesh Kumar
TI Unravelling the complexities of non-alcoholic steatohepatitis: The role
   of metabolism, transporters, and herb-drug interactions
SO LIFE SCIENCES
LA English
DT Article
DE Nonalcoholic steatohepatitis; Nonalcoholic fatty liver disease; Drug
   metabolism; Transporters; Dietary and genetic models; Herb -drug
   interaction
ID FATTY LIVER-DISEASE; IMPORTANT PHARMACOGENE INFORMATION;
   UDP-GLUCURONOSYLTRANSFERASES UGTS; CYTOCHROME-P450 2E1; IN-VITRO;
   SULFOTRANSFERASE EXPRESSION; GLOBAL EPIDEMIOLOGY; PROGRESSIVE STAGES;
   HEPATIC STEATOSIS; OXIDATIVE STRESS
AB Nonalcoholic fatty liver disease (NAFLD) is a mainstream halting liver disease with high prevalence in North America, Europe, and other world regions. It is an advanced form of NAFLD caused by the amassing of fat in the liver and can progress to the more severe form known as non-alcoholic steatohepatitis (NASH). Until recently, there was no authorized pharmacotherapy reported for NASH, and to improve the patient's metabolic syndrome, the focus is mainly on lifestyle modification, weight loss, ensuring a healthy diet, and increased physical activity; however, the recent approval of Rezdiffra (Resmetirom) by the US FDA may change this narrative. As per the reported studies, there is an increased articulation of uptake and efflux transporters of the liver, including OATP and MRP, in NASH, leading to changes in the drug's pharmacokinetic properties. This increase leads to alterations in the pharmacokinetic properties of drugs. Furthermore, modifications in Cytochrome P450 (CYP) enzymes can have a significant impact on these properties. Xenobiotics are metabolized primarily in the liver and constitute liver enzymes and transporters. This review aims to delve into the role of metabolism, transport, and potential herb-drug interactions in the context of NASH.
C1 [Somabattini, Ravi Adinarayan; Sherin, Sahla; Siva, Bhukya; Chowdhury, Neelanjan; Nanjappan, Satheesh Kumar] Natl Inst Pharmaceut Educ & Res NIPER, Dept Nat Prod, 168 Maniktala Main Rd, Kolkata 700054, W Bengal, India.
C3 National Institute of Pharmaceutical Education & Research, S.A.S. Nagar
   (Mohali)
RP Nanjappan, SK (corresponding author), Natl Inst Pharmaceut Educ & Res NIPER, Dept Nat Prod, 168 Maniktala Main Rd, Kolkata 700054, W Bengal, India.
EM satheesh.niperk@nic.in
RI Somabattini, Ravi/R-3052-2018; Nanjappan, Satheesh Kumar/LFT-6847-2024
OI Nanjappan, Satheesh Kumar/0000-0002-5771-7200; Somabattini,
   Ravi/0000-0003-4823-5215; BHUKYA, SIVA/0009-0006-9205-2167
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NR 273
TC 3
Z9 3
U1 2
U2 14
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0024-3205
EI 1879-0631
J9 LIFE SCI
JI Life Sci.
PD AUG 15
PY 2024
VL 351
AR 122806
DI 10.1016/j.lfs.2024.122806
EA JUN 2024
PG 18
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA WD5W2
UT WOS:001252954400001
PM 38852799
DA 2025-06-11
ER

PT J
AU Bayram, B
   Türker, PF
AF Bayram, B.
   Turker, P. F.
TI Dietary iron intake aggravates dyslipidaemia by elevating ferritin
   levels in patients with insulin resistance and cardiovascular diseases:
   A cross-sectional study
SO ACTA ALIMENTARIA
LA English
DT Article
DE ferritin; cardiometabolic diseases; insulin resistance; dietary iron;
   cardiovascular diseases
ID SERUM FERRITIN; METABOLIC SYNDROME; NATIONAL-HEALTH; HEART-FAILURE;
   RISK; MEN
AB Dietary iron intake causes the elevation of ferritin levels, and higher iron intake might improve insulin resistance and cardiovascular diseases. The aim of this study was to determine the relationship between dietary iron intake and serum ferritin levels, insulin resistance, and nutritional status in patients with cardiovascular disease. Health information of individuals were obtained with a questionnaire form. There were a total of 103 patients, 59 male (57.3%) and 44 female (42.7%). Patients also filled a questionnaire on dietary habits, a 3-day food record. There was a statistically significant difference between ferritin quartiles and total cholesterol, HDL-C, non-HDL-C, LDL-C/HDL-C ratio, and TG/HDL-C ratio (P < 0.05). Study data show that dietary iron intake was associated with the elevation of serum ferritin levels (P < 0.05) and this difference was significant in Q1 and Q4 groups in post-hoc analysis. There was a negative correlation between serum ferritin levels and total cholesterol and HDL-C in patients with insulin resistance (r = -0.384, P < 0.05; r = -0.520, P < 0.05). In conclusion we found a strong association between serum ferritin levels and inflammation, causing an oxidative stress, atherosclerosis, and bringing along cardiometabolic diseases such as cardiovascular diseases and type 2 DM.
C1 [Bayram, B.] Hasan Kalyoncu Univ, Fac Hlth Sci, Dept Nutr & Dietet, TR-27010 Gaziantep, Turkiye.
   [Turker, P. F.] Baskent Univ, Fac Hlth Sci, Dept Nutr & Dietet, TR-06790 Ankara, Turkiye.
C3 Hasan Kalyoncu University; Baskent University
RP Bayram, B (corresponding author), Hasan Kalyoncu Univ, Fac Hlth Sci, Dept Nutr & Dietet, TR-27010 Gaziantep, Turkiye.
EM buse.kiratli@hku.edu.tr
RI Türker, Perim/ABM-3793-2022; BAYRAM, Buse/AAJ-8708-2021
OI Bayram, Buse/0000-0001-5544-3333
CR Alkerwi A, 2019, BMC MED RES METHODOL, V19, DOI 10.1186/s12874-019-0669-0
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NR 25
TC 0
Z9 0
U1 0
U2 0
PU AKADEMIAI KIADO ZRT
PI BUDAPEST
PA BUDAFOKI UT 187-189-A-3, H-1117 BUDAPEST, HUNGARY
SN 0139-3006
EI 1588-2535
J9 ACTA ALIMENT HUNG
JI Acta Aliment.
PD MAR
PY 2024
VL 53
IS 1
BP 1
EP 11
DI 10.1556/066.2023.00197
PG 11
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA QU7M0
UT WOS:001223447300006
OA hybrid, Green Accepted
DA 2025-06-11
ER

PT J
AU Ning, DS
   Chen, YJ
   Lin, CJ
   Wang, CC
   Zhao, HW
   Wang, KT
   Lee, MC
   Tayo, LL
   Chiu, WC
   Yeh, CL
   Lee, CJ
AF Ning, De-Shan
   Chen, Yu-Ju
   Lin, Chien-Ju
   Wang, Ching-Chiung
   Zhao, Hong-Wei
   Wang, Kun-Teng
   Lee, Ming-Chung
   Tayo, Lemmuel L.
   Chiu, Wan-Chun
   Yeh, Chiu-Li
   Lee, Chia-Jung
TI Hepatoprotective effect of botanical drug formula on high-fat
   diet-induced non-alcoholic fatty liver disease by inhibiting lipogenesis
   and promoting anti-oxidation
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Article
DE non-alcoholic fatty liver disease (NAFLD); network pharmacology;
   herb-based supplements; puerarin; AMPK pathway; anti-oxidation
ID PUERARIA-LOBATA; MEDICINE; GENES
AB With the prevalence of obesity and other components of metabolic syndrome, Non-alcoholic fatty liver disease (NAFLD) has become increasingly common. In recent years, much attention has been paid to various plant sources, hoping to find a treatment for NAFLD in plants. The Livsooth authentic herbal formula (LAH,(sic)(sic)), a botanical drug formula combined with Puerariae lobatae radix, Lonicerae japonicae flos, Hoveniae semen, and Siraitiae fructus. This study used a network pharmacology approach to predict the potential mechanisms of LAH against NAFLD. Gene Ontology (GO) and KEGG pathway enrichment analyses have identified potential biochemical and signaling pathways. Subsequently, the potential mechanism of action of LAH on NAFLD predicted by network pharmacology analysis was validated in a high-fat diet (HFD)-induced NAFLD model in C57BL/6 mice. Our results demonstrated that LAH ameliorated hepatocyte steatosis in liver tissue by activating the AMPK pathway and decreasing serum triglycerides, low-density lipoprotein, glucose, and cholesterol. Besides, LAH increased the hepatic antioxidant enzymes activities, suggested that LAH improved oxidative stress markers in HFD induced NAFLD mice. In vitro experiments confirmed that the active component of LAH, puerarin, regulates lipid accumulation through the AMPK pathway. In conclusion, our study shows that network pharmacology predictions are consistent with experimental validation. LAH can be a candidate supplement for the prevention of NAFLD.
C1 [Ning, De-Shan; Zhao, Hong-Wei] Infinitus China Co Ltd, Guangzhou, Peoples R China.
   [Chen, Yu-Ju; Wang, Ching-Chiung; Lee, Chia-Jung] Taipei Med Univ, PhD Program Clin Drug Dev Herbal Med, Taipei, Taiwan.
   [Lin, Chien-Ju] Kaohsiung Med Univ, Coll Pharm, Sch Pharm, Kaohsiung, Taiwan.
   [Wang, Ching-Chiung; Lee, Chia-Jung] Taipei Med Univ, Grad Inst Pharmacognosy, Taipei, Taiwan.
   [Wang, Ching-Chiung] Taipei Med Univ, Sch Pharm, Taipei, Taiwan.
   [Wang, Ching-Chiung; Lee, Chia-Jung] Taipei Med Univ Hosp, Tradit Herbal Med Res Ctr, Taipei, Taiwan.
   [Wang, Kun-Teng; Lee, Ming-Chung] Herbiotek Co Ltd, New Taipei, Taiwan.
   [Tayo, Lemmuel L.] Mapua Univ, Sch Chem Biol Mat Sci & Engn, Manila, Philippines.
   [Chiu, Wan-Chun; Yeh, Chiu-Li] Taipei Med Univ, Coll Nutr, Sch Nutr & Hlth Sci, Taipei, Taiwan.
   [Chiu, Wan-Chun] Taipei Med Univ, Wan Fang Hosp, Dept Nutr, Taipei, Taiwan.
C3 Taipei Medical University; Kaohsiung Medical University; Taipei Medical
   University; Taipei Medical University; Taipei Medical University
   Hospital; Taipei Medical University; Mapua University; Taipei Medical
   University; Taipei Municipal WanFang Hospital; Taipei Medical University
RP Lee, CJ (corresponding author), Taipei Med Univ, PhD Program Clin Drug Dev Herbal Med, Taipei, Taiwan.; Lee, CJ (corresponding author), Taipei Med Univ, Grad Inst Pharmacognosy, Taipei, Taiwan.; Lee, CJ (corresponding author), Taipei Med Univ Hosp, Tradit Herbal Med Res Ctr, Taipei, Taiwan.
EM cjlee@tmu.edu.tw
RI Chen, Chun-Yu/L-7084-2013; Chiu, Wan-Chun/AAW-9950-2020
OI tayo, lemmuel/0000-0002-0869-2131; Chiu, Wan-Chun/0000-0003-4638-5412
FU Infinitus (China) Company Ltd; Herbiotek Co., Ltd.;  [A-109-003]
FX This work was supported by grants from Infinitus (China) Company Ltd.
   and Herbiotek Co., Ltd. (Project code: A-109-003).
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NR 47
TC 2
Z9 2
U1 3
U2 26
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD NOV 24
PY 2022
VL 13
AR 1026912
DI 10.3389/fphar.2022.1026912
PG 15
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 6V2GH
UT WOS:000894872700001
PM 36506588
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Nguyen, HD
   Oh, H
   Hoang, NHM
   Kim, MS
AF Nguyen, Hai Duc
   Oh, Hojin
   Hoang, Ngoc Hong Minh
   Kim, Min-Sun
TI Association between heavy metals, high-sensitivity C-reaction protein
   and 10-year risk of cardiovascular diseases among adult Korean
   population
SO SCIENTIFIC REPORTS
LA English
DT Article
ID METABOLIC SYNDROME; OXIDATIVE STRESS; BLOOD-PRESSURE; NATIONAL-HEALTH;
   CADMIUM; LEAD; MERCURY; EXPOSURE; LEVEL; HYPERTENSION
AB The prevalence of cardiovascular diseases (CVDs) in Korea tends to be increasing. It has worsened during the COVID-19 pandemic. Increasing evidence shows heavy metals are associated with increased CVD risk. We aimed to determine the association between the serum heavy metal levels and 10-year risk of CVDs and to predict risks of CVDs based on marginal effects. Heavy metals were measured by a graphite furnace atomic absorption spectrometry and direct mercury analyzer. The results show a significant relationship between the increase in cadmium, lead, mercury, hs-CRP levels and the 10-year risk of CVD after adjustment for serum cotinine, age group, sex, body mass index, a family history of CVDs, diabetes or hyperlipidemia, high-risk drinking, physical activity, and diabetes. A doubling of serum cadmium, lead, mercury, and hs-CRP was associated with the increase in the 10-year risk of CVD by 0.14%, 0.10%, 0.11% and 0.22%, respectively. Therefore, a special concern should be given to the harmful impacts of heavy metals on the 10-year risk of CVD. It is important to develop a prevention strategy targeting the high-risk population to slow down this progression to risk factors related to heavy metals and reduce prevalence. Remarkedly, hs-CRP is the most validated and widely used inflammatory marker, and could be a potential clinical value in predicting and monitoring CVDs.
C1 [Nguyen, Hai Duc; Oh, Hojin; Hoang, Ngoc Hong Minh; Kim, Min-Sun] Sunchon Natl Univ, Coll Pharm, Dept Pharm, Sunchon 57922, North Korea.
   [Nguyen, Hai Duc; Oh, Hojin; Hoang, Ngoc Hong Minh; Kim, Min-Sun] Sunchon Natl Univ, Res Inst Life & Pharmaceut Sci, Sunchon 57922, North Korea.
RP Kim, MS (corresponding author), Sunchon Natl Univ, Coll Pharm, Dept Pharm, Sunchon 57922, North Korea.; Kim, MS (corresponding author), Sunchon Natl Univ, Res Inst Life & Pharmaceut Sci, Sunchon 57922, North Korea.
EM minsun@scnu.ac.kr
RI Hoang, Ngoc/R-2353-2017; Oh, Hojin/ABA-7781-2021; Nguyen Duc,
   Hai/AAD-8210-2020
OI Nguyen Duc, Hai/0000-0001-8419-7784; Oh, Hojin/0000-0002-4022-5998
FU National Research Foundation of Korea (NRF) - Korean government (MEST)
   [NRF2013R1A1A3008851, 2018R1D1A1B07049610]
FX This study supported by grants National Research Foundation of Korea
   (NRF) grant funded by the Korean government (MEST) (grant nos.
   NRF2013R1A1A3008851 and 2018R1D1A1B07049610).
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NR 53
TC 44
Z9 45
U1 1
U2 19
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD JUL 19
PY 2021
VL 11
IS 1
AR 14664
DI 10.1038/s41598-021-94158-9
PG 14
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA TM9AU
UT WOS:000675839300031
PM 34282223
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Tinkov, AA
   Bogdanski, P
   Skrypnik, D
   Skrypnik, K
   Skalny, AV
   Aaseth, J
   Skalnaya, MG
   Suliburska, J
AF Tinkov, Alexey A.
   Bogdanski, Pawel
   Skrypnik, Damian
   Skrypnik, Katarzyna
   Skalny, Anatoly V.
   Aaseth, Jan
   Skalnaya, Margarita G.
   Suliburska, Joanna
TI Trace Element and Mineral Levels in Serum, Hair, and Urine of Obese
   Women in Relation to Body Composition, Blood Pressure, Lipid Profile,
   and Insulin Resistance
SO BIOMOLECULES
LA English
DT Article
DE obesity; metabolic syndrome; insulin resistance; copper; selenium
ID HIGH-FAT DIET; OXIDATIVE STRESS; ZINC; MAGNESIUM; SELENIUM; COPPER;
   IRON; DEFICIENCY; CALCIUM; WEIGHT
AB The objective of this study was to evaluate serum, hair, and urinary trace element and mineral content in normal-weight and obese women in relation to metabolic risk factors. A total of 80 women aged 30-70 y.o. were enrolled in the obese group (n = 40) and normal-weight group (n = 40). Serum, hair, and urinary trace element and mineral levels were assessed using inductively coupled plasma spectrometry. Body fat percentage was evaluated using bioimpedance. Obese subjects were characterized by significantly higher body fat percentage, blood pressure, serum triglyceride concentration, and insulin resistance. Serum Ca, Fe, Mg, Se, V, Zn levels, hair Fe, Mg, V content, and urinary Se and V concentrations were found to be lower in obese subjects as compared to lean controls. In turn, serum Cu and urinary Fe levels in obese women were characterized by a significant increase. In multiple regression models serum Cu, Se, and Zn levels were significantly associated with BMI even after adjustment for blood biochemistry, body composition, and blood pressure. Serum trace element and mineral levels also significantly contributed to group discrimination. These findings allow to propose that obesity-associated disturbances in trace element and mineral status may at least partially contribute to metabolic risk in obese subjects.
C1 [Tinkov, Alexey A.; Skalny, Anatoly V.; Skalnaya, Margarita G.] Yaroslavl State Univ, Lab Ecobiomonitoring & Qual Control, Sovetskaya St 14, Yaroslavl 150000, Russia.
   [Bogdanski, Pawel; Skrypnik, Damian] Poznan Univ Med Sci, Dept Treatment Obes Metab Disorders & Clin Dietet, Szamarzewskiego St 84, PL-60569 Poznan, Poland.
   [Skrypnik, Katarzyna; Suliburska, Joanna] Poznan Univ Life Sci, Dept Human Nutr & Dietet, Ul Wojska Polskiego 31, PL-60624 Poznan, Poland.
   [Aaseth, Jan] Innlandet Hosp Trust, Dept Res, N-2380 Brumunddal, Norway.
C3 Yaroslavl State University; Poznan University of Medical Sciences;
   Poznan University of Life Sciences; Innlandet Hospital Trust
RP Suliburska, J (corresponding author), Poznan Univ Life Sci, Dept Human Nutr & Dietet, Ul Wojska Polskiego 31, PL-60624 Poznan, Poland.
EM tinkov.a.a@gmail.com; pbogdanski@ump.edu.pl; damian.skrypnik@gmail.com;
   katarzyna.skrypnik@up.poznan.pl; skalny3@microelements.ru;
   jaol-aas@online.no; skalnaya@yandex.ru; joanna.suliburska@up.poznan.pl
RI Skrypnik, Damian/AAZ-9602-2021; Skrypnik, Katarzyna/LRU-0050-2024;
   Skalny, Anatoly/J-3953-2019; Bogdański, Paweł/ABB-2938-2020; Tinkov,
   Alexey/H-5842-2016; Aaseth, Jan/J-6764-2017
OI Suliburska, Joanna/0000-0002-0937-8427; Aaseth, Jan/0000-0002-7518-5703;
   Skrypnik, Damian/0000-0001-5643-6899; Skrypnik,
   Katarzyna/0000-0002-4173-5965; Bogdanski, Pawel/0000-0002-0563-1624
FU Russian Ministry of Science and Higher Education [0856-2020-0008]
FX The study was performed with the support of the Russian Ministry of
   Science and Higher Education, Project No 0856-2020-0008.
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NR 46
TC 26
Z9 27
U1 0
U2 8
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2218-273X
J9 BIOMOLECULES
JI Biomolecules
PD MAY
PY 2021
VL 11
IS 5
AR 689
DI 10.3390/biom11050689
PG 12
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA SG4KA
UT WOS:000653408700001
PM 34064348
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Liu, YH
   Li, Y
   Dong, SS
   Han, L
   Guo, RX
   Fu, YR
   Zhang, SH
   Chen, JQ
AF Liu, Yanhua
   Li, Yang
   Dong, Shanshan
   Han, Lu
   Guo, Ruixin
   Fu, Yourong
   Zhang, Shenghu
   Chen, Jianqiu
TI The risk and impact of organophosphate esters on the development of
   female-specific cancers: Comparative analysis of patients with benign
   and malignant tumors
SO JOURNAL OF HAZARDOUS MATERIALS
LA English
DT Article
DE Organophosphate esters; Endocrine Disruptors; Female-specific tumors;
   Exposure risk; Female's disease
ID BROMINATED FLAME RETARDANTS; BREAST-CANCER; CERVICAL-CANCER; HUMAN
   EXPOSURE; BISPHENOL-A; METABOLIC SYNDROME; OXIDATIVE STRESS; REACTIVE
   OXYGEN; DIETARY-INTAKE; INDOOR
AB Environmental pollution has become a concern for public health. As endocrine disruptors, organophosphate esters (OPEs) causes many diseases via human exposure. However, there is limited research on the risk of OPE exposure to female-specific cancers. Blood measurements are biomarkers for chemical exposures by their definition. Thus, in the present study, 11 OPEs were analyzed in the plasma of patients with 4 female-specific tumors. 2-Ethylhexyl diphenyl phosphate (EHDPP) was detected at the highest levels in all groups. The Spearman correlation test results showed significantly positive correlations between some OPEs in each group, which indicated that those OPEs had similar sources and/or behaved similarly in the patients of each group. However, compared with different patient groups, obvious differences in the correlation results were noted, implying the differences in the metabolism of OPEs between different groups. The results of the correlation analysis showed that EHDPP concentration was associated with the risk of breast cancer (p < 0.05), while tri-n-butyl phosphate (TNBP), tris (methylphenyl) phosphate (TMPP), triphenyl phosphate (TPHP), and EHDPP concentrations were associated with the risk of cervical cancer (p < 0.05 or p < 0.01). These findings indicated that OPEs were associated with the risk of breast and cervical cancer.
C1 [Liu, Yanhua; Li, Yang; Dong, Shanshan; Han, Lu; Guo, Ruixin; Chen, Jianqiu] China Pharmaceut Univ, Dept Environm Sci, Nanjing 211198, Peoples R China.
   [Zhang, Shenghu] Minist Ecol & Environm, Nanjing Inst Environm Sci, Nanjing 210042, Peoples R China.
   [Guo, Ruixin] Jiangsu Prov Key Lab Environm Engn, Nanjing 210036, Peoples R China.
   [Li, Yang; Fu, Yourong] Wuhan Univ, Zhongnan Hosp, Blood Transfus Dept, Wuhan 430071, Peoples R China.
C3 China Pharmaceutical University; Nanjing Institute of Environmental
   Sciences, Ministry of Ecology & Environment; Wuhan University
RP Chen, JQ (corresponding author), China Pharmaceut Univ, Dept Environm Sci, Nanjing 211198, Peoples R China.; Zhang, SH (corresponding author), Minist Ecol & Environm, Nanjing Inst Environm Sci, Nanjing 210042, Peoples R China.
EM zsh@nies.org; cjqalga@163.com
FU Open Research Fund of Jiangsu Province Key Laboratory of Environmental
   Engineering [KF2018005]; National Natural Science Foundation of China
   [21876207]; National Key RD project [2017YFD0800705]; Double First-Class
   university project, China [CPU2018GY21, CPU2018GY24]; Cooperation
   Project of SEUCPU [2242019K3DZ08]
FX This project was supported by the Open Research Fund of Jiangsu Province
   Key Laboratory of Environmental Engineering (KF2018005), National
   Natural Science Foundation of China (21876207), National Key R&D project
   (2017YFD0800705), Double First-Class university project, China
   (CPU2018GY21, 24), and Cooperation Project of SEUCPU (2242019K3DZ08). We
   also thank College Undergraduate Training Program for Innovation and
   Entrepreneurship.
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NR 66
TC 44
Z9 52
U1 16
U2 164
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0304-3894
EI 1873-3336
J9 J HAZARD MATER
JI J. Hazard. Mater.
PD FEB 15
PY 2021
VL 404
AR 124020
DI 10.1016/j.jhazmat.2020.124020
PN B
PG 8
WC Engineering, Environmental; Environmental Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering; Environmental Sciences & Ecology
GA QA4QG
UT WOS:000613428900009
PM 33049558
DA 2025-06-11
ER

PT J
AU Galbán-Velázquez, S
   Esteban, J
   Çakmak, G
   Artacho-Cordón, F
   León, J
   Barril, J
   Vela-Soria, F
   Martin-Olmedo, P
   Fernandez, MF
   Pellín, MC
   Arrebola, JP
AF Galban-Velazquez, Suylen
   Esteban, Javier
   Cakmak, Gonca
   Artacho-Cordon, Francisco
   Leon, Josefa
   Barril, Jose
   Vela-Soria, Fernando
   Martin-Olmedo, Piedad
   Fernandez, Mariana F.
   Cruz Pellin, M.
   Arrebola, Juan P.
TI Associations of persistent organic pollutants in human adipose tissue
   with retinoid levels and their relevance to the redox microenvironment
SO ENVIRONMENTAL RESEARCH
LA English
DT Article
DE Persistent organic pollutants; Polychlorinated biphenyls; Retinoid
   system; Superoxide dismutase; Oxidative stress
ID ENDOCRINE-DISRUPTING CHEMICALS; METABOLIC SYNDROME COMPONENTS;
   BINDING-PROTEIN; VITAMIN-A; INSULIN-RESISTANCE;
   POLYCHLORINATED-BIPHENYLS; ADULT COHORT; X-RECEPTOR; SERUM
   CONCENTRATIONS; GENE-EXPRESSION
AB Humans are exposed to a myriad of chemical substances in both occupational and environmental settings. Persistent organic pollutants (POPs) have drawn attention for their adverse effects including cancer and endocrine disruption. Herein, the objectives were 1) to describe serum and adipose tissue retinol levels, along with serum retinol binding protein 4 (RBP4) concentrations, and 2) to assess the associations of adipose tissue POP levels with these retinoid parameters, as well as their potential interaction with the previously-observed POP-related disruption of redox microenvironment. Retinol was measured in both serum and adipose tissue along with RBP4 levels in serum samples of 236 participants of the GraMo adult cohort. Associations were explored by multivariable linear regression analyses and Weighted Quantile Sum regression. Polychlorinated biphenyls (PCBs) 180, 153 and 138 were related to decreased adipose tissue retinol levels and increased serum RBP4/retinol ratio. Dicofol concentrations > limit of detection were associated with decreased retinol levels in serum and adipose tissue. Additionally, increased adipose tissue retinol levels were linked to an attenuation in previously-reported associations of adipose tissue PCB-153 with in situ superoxide dismutase activity. Our results revealed a suggestive link between retinoids, PCBs and redox microenvironment, potentially relevant for both mechanistic and public health purposes.
C1 [Galban-Velazquez, Suylen; Esteban, Javier; Cakmak, Gonca; Barril, Jose; Cruz Pellin, M.] Univ Miguel Hernandez Elche, Inst Bioingn, Avda Univ S-N, E-03202 Elche, Spain.
   [Cakmak, Gonca] Gazi Univ, Dept Toxicol, Fac Pharm, TR-06330 Ankara, Turkey.
   [Artacho-Cordon, Francisco; Fernandez, Mariana F.] Univ Granada, Dept Radiol & Phys Med, Granada 18016, Spain.
   [Artacho-Cordon, Francisco; Fernandez, Mariana F.; Arrebola, Juan P.] CIBER Epidemiol & Publ Hlth CIBERESP, Madrid 28029, Spain.
   [Leon, Josefa; Vela-Soria, Fernando; Martin-Olmedo, Piedad; Fernandez, Mariana F.; Arrebola, Juan P.] Inst Invest Biosanitaria Ibs GRANADA, Granada, Spain.
   [Leon, Josefa] Hosp Univ San Cecilio Granada, Unidad Gest Clin Aparato Digest, Granada, Spain.
   [Leon, Josefa] CIBER Hepat & Digest Dis CIBEREHD, Madrid 28029, Spain.
   [Martin-Olmedo, Piedad] Andalusian Sch Publ Hlth, Granada 18011, Spain.
   [Arrebola, Juan P.] Univ Granada, Dept Prevent Med & Publ Hlth, Granada, Spain.
C3 Universidad Miguel Hernandez de Elche; Gazi University; University of
   Granada; CIBER - Centro de Investigacion Biomedica en Red; CIBERESP;
   Instituto de Investigacion Biosanitaria IBS Granada; Hospital
   Universitario San Cecilio; CIBER - Centro de Investigacion Biomedica en
   Red; CIBEREHD; Escuela Andaluza de Salud Publica; University of Granada
RP Esteban, J (corresponding author), Univ Miguel Hernandez Elche, Inst Bioingn, Avda Univ S-N, E-03202 Elche, Spain.
EM jesteban@umh.es
RI Esteban, Javier/A-5640-2019; Arrebola, Juan/A-5205-2017; Fernandez,
   Mariana/C-9877-2012; Leon, Pepi/K-8972-2014; CAKMAK,
   GONCA/HZL-0948-2023; Artacho-Cordon, Francisco/A-3166-2015
OI CAKMAK, GONCA/0000-0002-6283-5404; MARTIN-OLMEDO,
   PIEDAD/0000-0002-3343-9760; Esteban, Javier/0000-0003-3760-8223;
   Vela-Soria, Fernando/0000-0002-6235-8441; Artacho-Cordon,
   Francisco/0000-0003-3850-6173
FU CIBER de Epidemiologia y Salud Publica (CIBERESP); Instituto de Salud
   Carlos III, Junta de Andalucia; European Regional Development Fund-FEDER
   [PI16/01858, PI16/01812, PI20/01568, PI-13/02406]; Generalitat
   Valenciana; Scientific and Technological Research Council of Turkey
   [TUBITAK-2219]; Ramon y Cajal Program (Ministerio de Economia, Industria
   y Competitividad, Spain) [RYC-2016-20155]
FX This work was supported by research grants from CIBER de Epidemiologia y
   Salud Publica (CIBERESP), Instituto de Salud Carlos III, Junta de
   Andalucia, European Regional Development Fund-FEDER (PI16/01858,
   PI16/01812, PI20/01568 and PI-13/02406) and Generalitat Valenciana. Dr.
   G Cakmak is awarded a grant by The Scientific and Technological Research
   Council of Turkey (TUBITAK-2219). Dr. JP Arrebola is under contract
   within the Ram ' on y Cajal Program (RYC-2016-20155, Ministerio de
   Economia, Industria y Competitividad, Spain).
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NR 122
TC 7
Z9 7
U1 2
U2 17
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0013-9351
EI 1096-0953
J9 ENVIRON RES
JI Environ. Res.
PD APR
PY 2021
VL 195
AR 110764
DI 10.1016/j.envres.2021.110764
EA FEB 2021
PG 11
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA RM0BZ
UT WOS:000639328800057
PM 33497679
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Kalmukova, OO
   Yurchenko, A
   Savchuk, AM
   Dzerzhynsky, ME
AF Kalmukova, O. O.
   Yurchenko, A., V
   Savchuk, A. M.
   Dzerzhynsky, M. E.
TI Changes in the Inflammatory Status in White Adipose Tissue of Rats with
   Diet-Induced Obesity at Different Regimens of Melatonin Administration
SO CYTOLOGY AND GENETICS
LA English
DT Article
DE high-calorie diet-induced obesity; inflammation; chronobiology;
   melatonin; cytokine; fibrosis; mast cells; adipocytes
ID METABOLIC SYNDROME; OXIDATIVE STRESS; MT2 MELATONIN; SENSITIVITY; CELLS;
   ADIPOCYTES; PARAMETERS; RECEPTORS; FIBROSIS; MODEL
AB The effects of different regimens (morning and evening) of melatonin administration (30 mg/kg/day during 7 weeks) on the course of inflammation processes in visceral white adipose tissue (the presence of macrophages that formed crown-like structures around the adipocytes, fibrosis level and mast cell numbers in white adipose tissue, and the content of proinflammatory (IL-1 beta, IL-8, tumor necrosis factor alpha, and interferon gamma) and anti-inflammatory (IL-4 and IL-10) cytokines in blood serum) was analyzed in rats with obesity induced by a high-calorie diet. Melatonin administration was followed by changes in the numbers of macrophages and mast cells in white adipose tissue of obese rats, and decreases of collagen fiber content (fibrosis) and the area of adipocytes were also demonstrated. Melatonin administration in the evening (1 h before the lights off) turned out to be more efficient than the morning administration (1 h after the lights on). Moreover, the level of anti-inflammatory cytokines increased in the blood serum of obese rats after melatonin administration, whereas the level of proinflammatory cytokines decreased at the same time. This demonstrates the anti-inflammatory effects of melatonin in the context of obesity development and serves as a theoretical prerequisite for further consideration of the possible use of melatonin in obesity treatment.
C1 [Kalmukova, O. O.; Yurchenko, A., V; Savchuk, A. M.; Dzerzhynsky, M. E.] Taras Shevchenko Natl Univ, Inst Biol & Med, Educ & Sci Ctr, UA-01601 Kiev, Ukraine.
C3 Ministry of Education & Science of Ukraine; Taras Shevchenko National
   University of Kyiv
RP Kalmukova, OO (corresponding author), Taras Shevchenko Natl Univ, Inst Biol & Med, Educ & Sci Ctr, UA-01601 Kiev, Ukraine.
EM olesiakalmukova28@gmail.com
RI ; Savchuk, Olexiy/K-2863-2014; Kalmukova, Olesia/HNQ-7252-2023
OI Dzerzhynskyi, Mykola/0009-0006-5969-8564; Savchuk,
   Olexiy/0000-0003-3621-6981; Kalmukova, Olesia/0000-0001-5025-0938
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NR 50
TC 1
Z9 1
U1 1
U2 6
PU PLEIADES PUBLISHING INC
PI NEW YORK
PA PLEIADES HOUSE, 7 W 54 ST, NEW YORK,  NY, UNITED STATES
SN 0095-4527
EI 1934-9440
J9 CYTOL GENET+
JI Cytol. Genet.
PD JAN
PY 2020
VL 54
IS 1
BP 38
EP 47
DI 10.3103/S0095452720010077
PG 10
WC Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Genetics & Heredity
GA KT8FN
UT WOS:000519247500006
DA 2025-06-11
ER

PT J
AU Wlodarczyk, M
   Jablonowska-Lietz, B
   Olejarz, W
   Nowicka, G
AF Wlodarczyk, Marta
   Jablonowska-Lietz, Beata
   Olejarz, Wioletta
   Nowicka, Grazyna
TI Anthropometric and Dietary Factors as Predictors of DNA Damage in Obese
   Women
SO NUTRIENTS
LA English
DT Article
DE DNA damage; obesity; dietary intake; vitamin C; vitamin E
ID C-REACTIVE PROTEIN; OXIDATIVE STRESS; CELLULAR SENESCENCE; COMET ASSAY;
   FATTY-ACIDS; REPAIR; MECHANISMS; CANCER; HEALTH; CELLS
AB Enhanced DNA damage and disturbances in DNA repair mechanisms are reported to be involved in the pathogenesis of chronic diseases like obesity, atherosclerosis, metabolic syndrome, diabetes, and cancer. The aim of the present study was to evaluate whether anthropometric factors and dietary habits are related to endogenous DNA damage. One hundred and fourteen premenopausal, apparently healthy women were included in the study: 88 obese individuals and 26 controls. The comet assay was used to measure basal DNA damage. Biochemical measurements included lipids, apolipoproteinAI, fasting insulin, glucose, and C-reactive protein high sensitivity (CRP-hs). Dietary intakes were assessed by 3-day food records. The mean level of DNA damage was almost two times higher in obese than in non-obese women (p < 0.001). Regression modeling showed that body mass index (BMI), daily intakes of energy, and vitamin C are key predictors of variance in basal DNA damage. Our data demonstrate the impact of obesity-associated inflammation on DNA damage and indicate that regardless of obesity, the level of DNA damage can be reduced by adequate intakes of vitamins C and E. It suggests that particular attention should be paid to the content of antioxidants in the diet of obese people and further studies are needed to modify dietary guidelines to prevent DNA damage in obese individuals.
C1 [Wlodarczyk, Marta; Olejarz, Wioletta; Nowicka, Grazyna] Med Univ Warsaw, Fac Pharm, Dept Biochem & Pharmacogen, Div Lab Med, Banacha 1B, PL-02097 Warsaw, Poland.
   [Wlodarczyk, Marta; Olejarz, Wioletta; Nowicka, Grazyna] Med Univ Warsaw, Ctr Preclin Res, Banacha 1B, PL-02097 Warsaw, Poland.
   [Jablonowska-Lietz, Beata] Natl Food & Nutr Inst, Ctr Promot Heathy Nutr & Phys Act, Powsinska 61-63, PL-02903 Warsaw, Poland.
C3 Medical University of Warsaw; Medical University of Warsaw
RP Wlodarczyk, M (corresponding author), Med Univ Warsaw, Fac Pharm, Dept Biochem & Pharmacogen, Div Lab Med, Banacha 1B, PL-02097 Warsaw, Poland.; Wlodarczyk, M (corresponding author), Med Univ Warsaw, Ctr Preclin Res, Banacha 1B, PL-02097 Warsaw, Poland.
EM marta.wlodarczyk@wum.edu.pl; bjablonowskalietz@gmail.com;
   wolejarz@wum.edu.pl; gnowicka@wum.edu.pl
RI Nowicka, Grażyna/U-6222-2019; Wlodarczyk, Marta/N-7700-2018
OI Nowicka, Grazyna/0000-0001-9556-6813; Wlodarczyk,
   Marta/0000-0003-1545-2547
FU National Science Centre [NN404087940, N404042/32/0945]; European
   Union-the European Regional Development Fund within the Operational
   Program (Innovative economy)
FX This work was supported by the National Science Centre (grant number
   NN404087940 and N404042/32/0945) and carried out with the use of CePT
   infrastructure financed by the European Union-the European Regional
   Development Fund within the Operational Program (Innovative economy for
   2007-2013).
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NR 70
TC 28
Z9 29
U1 0
U2 8
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD MAY
PY 2018
VL 10
IS 5
AR 578
DI 10.3390/nu10050578
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA GJ3LI
UT WOS:000435196000052
PM 29738492
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Serrano, A
   Nogales, F
   Sobrino, P
   Murillo, ML
   Carreras, O
   Ojeda, ML
AF Serrano, Alejandra
   Nogales, Fatima
   Sobrino, Paula
   Luisa Murillo, Maria
   Carreras, Olimpia
   Luisa Ojeda, Maria
TI Heart selenoproteins status of metabolic syndrome-exposed pups: A
   potential target for attenuating cardiac damage
SO MOLECULAR NUTRITION & FOOD RESEARCH
LA English
DT Article
DE Cardiac damage; Fetal programming; High fructose diet; Selenoproteins
ID INCREASED GENE-EXPRESSION; DIABETIC MOUSE HEART; CARDIOVASCULAR-DISEASE;
   INSULIN-RESISTANCE; SELENIUM STATUS; IMPACT; SUPPLEMENTATION;
   HYPERTROPHY; STRESS; LEVEL
AB Scope: Cardiac hypertrophy is the greatest complication inmetabolic syndrome (MS), in dams and in offspring. The most effective therapies to avoid the evolution of MS are anti-oxidants, anti-inflammatories, and insulin sensitizers. Among anti-oxidant elements, Selenium (Se) exerts its functions through selenoproteins, which are essential for the correct functioning of the cardiovascular system. The aim of the study is analyze selenoproteins' implication in the transmission of future cardiovascular problems to MS progeny.
   Methods and results: Heart Se deposits, antioxidant enzymes' activities, biomolecular oxidation, and the expression of selenoproteins, AMPK, and NF-kB were measured in the offspring of dams exposed to a fructose-rich diet (65%) during gestation and lactation, with a normal Se content (0.1 ppm). Thyroid hormones and MCP-1 serum levels, as well as blood pressure and heart rate were alsomeasured. Fructose-exposed pups have cardiomegaly, oxidation, and depletion in Se heart deposits, a decrease in selenoproteins' expression and in the p-AMPK/AMPKt energy ratio; an increase in NF-kB p65 expression, and a decrease of thyroid hormones and MCP-1. Heart rate and blood pressure were altered.
   Conclusion: These data indicate that dietary Se supplementation could be an inexpensive therapy for avoiding future cardiovascular complication in the progeny of MS dams.
C1 [Serrano, Alejandra; Nogales, Fatima; Sobrino, Paula; Luisa Murillo, Maria; Carreras, Olimpia; Luisa Ojeda, Maria] Univ Seville, Fac Pharm, Dept Physiol, Seville, Spain.
C3 University of Sevilla
RP Murillo, ML (corresponding author), Univ Seville, Fac Pharm, Dept Physiol, Seville, Spain.
EM ojedamuri11@us.es
RI Carreras, olimpia/P-9078-2019; Ojeda, Luisa/B-8571-2019; Nogales,
   F/B-8562-2019
OI Carreras, Olimpia/0000-0002-3858-0165; Maria Luisa, Ojeda
   Murillo/0000-0002-9160-2749; Nogales, Fatima/0000-0003-4844-2740
FU Andalusian Regional Government
FX Grants from Andalusian Regional Government for its support to CTS-193
   research group.
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NR 38
TC 8
Z9 8
U1 0
U2 6
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1613-4125
EI 1613-4133
J9 MOL NUTR FOOD RES
JI Mol. Nutr. Food Res.
PD DEC
PY 2016
VL 60
IS 12
BP 2633
EP 2641
DI 10.1002/mnfr.201600511
PG 9
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA EJ3ZV
UT WOS:000393156600010
PM 27520709
DA 2025-06-11
ER

PT J
AU Knaub, LA
   McCune, S
   Chicco, AJ
   Miller, M
   Moore, RL
   Birdsey, N
   Lloyd, MI
   Villarreal, J
   Keller, AC
   Watson, PA
   Reusch, JEB
AF Knaub, Leslie A.
   McCune, Sylvia
   Chicco, Adam J.
   Miller, Matthew
   Moore, Russell L.
   Birdsey, Nicholas
   Lloyd, Monique I.
   Villarreal, Juan
   Keller, Amy C.
   Watson, Peter A.
   Reusch, Jane E. B.
TI Impaired response to exercise intervention in the vasculature in
   metabolic syndrome
SO DIABETES & VASCULAR DISEASE RESEARCH
LA English
DT Article
DE Cyclic adenosine monophosphate response element binding protein;
   mitochondria; exercise; SHHF; diabetes; vasculature
ID ELEMENT-BINDING PROTEIN; LOW CARDIORESPIRATORY FITNESS; MUSCLE
   CELL-PROLIFERATION; ZUCKER OBESE RATS; PHYSICAL-ACTIVITY; MITOCHONDRIAL
   BIOGENESIS; INSULIN-RESISTANCE; DISEASE RISK; CREB; PHOSPHATIDYLINOSITOL
AB Physical activity decreases risk for diabetes and cardiovascular disease morbidity and mortality; however, the specific impact of exercise on the diabetic vasculature is unexamined. We hypothesized that an acute, moderate exercise intervention in diabetic and hypertensive rats would induce mitochondrial biogenesis and mitochondrial antioxidant defence to improve vascular resilience. SHHF/Mcc-fa(cp) lean (hypertensive) and obese (hypertensive, insulin resistant), as well as Sprague Dawley (SD) control rats were run on a treadmill for 8 days. In aortic lysates from SD rats, we observed a significant increase in subunit proteins from oxidative phosphorylation (OxPhos) complexes I-III, with no changes in the lean or obese SHHF rats. Exercise also increased the expression of mitochondrial antioxidant defence uncoupling protein 3 (UCP3) (p < 0.05) in SHHF lean rats, whereas no changes were observed in the SD or SHHF obese rats with exercise. We evaluated upstream signalling pathways for mitochondrial biogenesis, and only peroxisome proliferators-activated receptor gamma coactivator 1 alpha (PGC-1 alpha) significantly decreased in SHHF lean rats (p < 0.05) with exercise. In these experiments, we demonstrate absent mitochondrial induction with exercise exposure in models of chronic vascular disease. These findings suggest that chronic vascular stress results in decreased sensitivity of vasculature to the adaptive mitochondrial responses normally induced by exercise.
C1 [Knaub, Leslie A.; Miller, Matthew; Birdsey, Nicholas; Lloyd, Monique I.; Villarreal, Juan; Keller, Amy C.; Watson, Peter A.; Reusch, Jane E. B.] Univ Colorado Denver, Div Endocrinol Diabet & Metab, Aurora, CO 80045 USA.
   [Knaub, Leslie A.; Miller, Matthew; Birdsey, Nicholas; Lloyd, Monique I.; Keller, Amy C.; Watson, Peter A.; Reusch, Jane E. B.] Denver VA Med Ctr, Dept Med, Denver, CO USA.
   [McCune, Sylvia; Moore, Russell L.] Univ Colorado, Dept Integrat Physiol, Boulder, CO 80309 USA.
   [Chicco, Adam J.] Colorado State Univ, Dept Hlth & Exercise Sci, Ft Collins, CO 80523 USA.
C3 University of Colorado System; University of Colorado Anschutz Medical
   Campus; Children's Hospital Colorado; US Department of Veterans Affairs;
   Veterans Health Administration (VHA); Veterans Affairs Medical Center -
   Denver; University of Colorado System; University of Colorado Boulder;
   Colorado State University System; Colorado State University Fort Collins
RP Reusch, JEB (corresponding author), Univ Colorado Denver, Div Endocrinol Diabet & Metab, Anschutz Med Campus,12801 E 17th Ave,MS8106, Aurora, CO 80045 USA.
EM jane.reusch@ucdenver.edu
RI ; Moore, Russell/D-1040-2013
OI Reusch, Jane/0000-0001-8620-1003; Moore, Russell/0000-0002-6727-8985
FU Department of Veterans Affairs Office of Research and Development;
   National Institutes of Health [HL14985, UL1 RR025780]; American Heart
   Association [0835545N]; American Heart Association (AHA) [0835545N]
   Funding Source: American Heart Association (AHA)
FX This work was supported by the Department of Veterans Affairs Office of
   Research and Development (Merit Review JEBR and PAW), National
   Institutes of Health (HL14985, UL1 RR025780, JEBR) and American Heart
   Association Grant (0835545N, AJC).
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NR 65
TC 18
Z9 21
U1 0
U2 11
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1479-1641
EI 1752-8984
J9 DIABETES VASC DIS RE
JI Diabetes Vasc. Dis. Res.
PD MAY
PY 2013
VL 10
IS 3
BP 222
EP 238
DI 10.1177/1479164112459664
PG 17
WC Endocrinology & Metabolism; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Cardiovascular System & Cardiology
GA 122CR
UT WOS:000317293900005
PM 23162060
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Lebovitz, H
AF Lebovitz, Harold
TI Diabetes: Assessing the pipeline
SO ATHEROSCLEROSIS SUPPLEMENTS
LA English
DT Article; Proceedings Paper
CT Future Forum Conference
CY MAY, 2005
CL Budapest, HUNGARY
SP AstraZeneca
DE type 2 diabetes; metabolic syndrome; cardiovascular complications;
   GLP-1; amylin; PPAR; endocannabinoid
ID GLUCAGON-LIKE PEPTIDE-1; GLYCEMIC CONTROL; EXENATIDE EXENDIN-4;
   OVERWEIGHT PATIENTS; OXIDATIVE STRESS; TREATED PATIENTS; RISK-FACTORS;
   DOUBLE-BLIND; TYPE-2; INSULIN
AB Type 2 diabetes is recognised as a major cardiovascular risk factor, and future therapies must therefore address more than just blood glucose levels. Novel approaches to the treatment of type 2 diabetes are now at various stages of development or regulatory approval. Exenatide and pramlintide, analogues of gut-derived hormones glucagon-like peptide-1 (GLP-1) and amylin, respectively, have demonstrated improvements in glycaemic control and bodyweight in clinical studies and have been recently approved for treatment of type 2 diabetes. Initial studies have indicated that agents that activate both peroxisome proliferator-activated receptor (PPAR)alpha and gamma improve glycaemic control and have beneficial effects on lipid profiles. Two dual PPAR alpha/gamma agonists, muraglitazar and tesaglitazar, are under regulatory review and in phase III trials, respectively. Modulation of the endogenous endocannabinoid system by rimonabant, which is under regulatory review, has been shown to improve body weight, atherogenic lipid profiles and glycaemic control. In addition, enhanced understanding of the pathophysiology underlying the microvascular complications of type 2 diabetes has led to the development of targeted therapies for conditions such as diabetic retinopathy, including the protein kinase C (PKC)-antagonist ruboxistaurin, now in phase III trials. Such therapies should enable physicians to achieve more for their patients with type 2 diabetes. (c) 2006 Published by Elsevier Ireland Ltd.
C1 SUNY Hlth Sci Ctr Brooklyn, Dept Med, Staten Isl, NY 10310 USA.
C3 State University of New York (SUNY) System; SUNY Downstate Health
   Sciences University
RP Lebovitz, H (corresponding author), SUNY Hlth Sci Ctr Brooklyn, Dept Med, 416 Henderson Ave, Staten Isl, NY 10310 USA.
EM hlebovitz@attglobal.net
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NR 45
TC 9
Z9 13
U1 0
U2 2
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 1567-5688
EI 1878-5050
J9 ATHEROSCLEROSIS SUPP
JI Atheroscler. Suppl.
PD APR
PY 2006
VL 7
IS 1
BP 43
EP 49
DI 10.1016/j.atherosclerosissup.2006.01.007
PG 7
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Cardiovascular System & Cardiology
GA 046DR
UT WOS:000237792100007
PM 16504599
DA 2025-06-11
ER

PT J
AU Zhang, SL
   Wang, ZY
   Jiang, J
   Feng, GX
   Fan, SJ
AF Zhang, Songling
   Wang, Zhaoyu
   Jiang, Jin
   Feng, Guoxing
   Fan, Saijun
TI Lactobacillus reuteri's multifaceted role in mitigating ionizing
   radiation-induced injury in Drosophila melanogaster
SO FOOD & FUNCTION
LA English
DT Article
ID ACTIVATED PROTEIN-KINASE; LIFE-SPAN EXTENSION; STEM-CELLS; GUT
   MICROBIOTA; HIGH-FAT; MODULATION; AUTOPHAGY; TISSUE; AMPK;
   PHOSPHORYLATION
AB The numerous beneficial probiotic properties of Lactobacillus reuteri (L. reuteri) include decreasing metabolic syndrome, preventing disorders linked to oxidative stress, improving gut flora imbalances, controlling immunological function, and extending life span. Exposure to ionizing radiation is closely associated with several disorders. We examined the protective and salvaging effects of L. reuteri on ionizing radiation-induced injury to the intestinal tract, reproductive system, and nervous system of Drosophila melanogaster. We also examined its effects on lifespan, antioxidant capacity, progeny development, and behavioral aspects to assess the interaction between L. reuteri and ionizing radiation-induced injury. The findings demonstrated that L. reuteri improved the median survival time following irradiation and greatly extended its lifespan. In addition, it raised SOD activity, reduced ROS levels in intestinal epithelial cells, and increased the quantity of intestinal stem cells. Furthermore, L. reuteri enhanced the adult male flies' capacity to move. It also successfully safeguarded the generations' growth and development. L. reuteri dramatically enhanced expression of the AMPK alpha gene and regulated expression of its pathway-related gene, mTOR, as well as the autophagy-related genes Atg1 and Atg5 in female Drosophila exposed to irradiation. Notably, no prior reports have been made on the possible effects of L. reuteri on injuries caused by irradiation. As a result, our research offers important new information regarding L. reuteri's possible role as a shield against ionizing radiation-induced injury.
C1 [Zhang, Songling; Wang, Zhaoyu; Jiang, Jin; Feng, Guoxing; Fan, Saijun] Tianjin Inst Hlth Sci, Inst Radiat Med, Chinese Acad Med Sci & Peking Union Med Coll, Tianjin Key Lab Radiat Med & Mol Nucl Med, Tianjin 300192, Peoples R China.
C3 Chinese Academy of Medical Sciences - Peking Union Medical College;
   Peking Union Medical College; Institute of Radiation Medicine - CAMS
RP Feng, GX; Fan, SJ (corresponding author), Tianjin Inst Hlth Sci, Inst Radiat Med, Chinese Acad Med Sci & Peking Union Med Coll, Tianjin Key Lab Radiat Med & Mol Nucl Med, Tianjin 300192, Peoples R China.
EM zhangsongling@irm-cams.ac.cn; fengguoxing@irm-cams.ac.cn;
   fansaijun@irm-cams.ac.cn
RI Zhang, Songling/JFB-3419-2023; Wang, Zhaoyu/KIA-1324-2024; Feng,
   Guoxing/AAD-6163-2019
FU CAMS Innovation Fund for Medical Sciences [2021-I2M-1-042,
   2022-I2M-2-003]
FX This study was supported by CAMS Innovation Fund for Medical Sciences
   (2021-I2M-1-042, 2022-I2M-2-003).
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NR 91
TC 2
Z9 2
U1 1
U2 10
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PD APR 2
PY 2024
VL 15
IS 7
BP 3522
EP 3538
DI 10.1039/d3fo05422e
EA MAR 2024
PG 17
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA MS4H0
UT WOS:001182034400001
PM 38465872
DA 2025-06-11
ER

PT J
AU Guney, C
   Bal, NB
   Akar, F
AF Guney, Ceren
   Bal, Nur Banu
   Akar, Fatma
TI The impact of dietary fructose on gut permeability, microbiota,
   abdominal adiposity, insulin signaling and reproductive function
SO HELIYON
LA English
DT Article
DE Dietary fructose; Gut permeability and dysbiosis; Abdominal adiposity;
   Inflammation; Insulin signaling; Reproductive function
ID NECROSIS-FACTOR-ALPHA; FATTY LIVER-DISEASE; ACTIVATED PROTEIN-KINASES;
   MALE WISTAR RATS; HEPATIC STEATOSIS; OXIDATIVE STRESS; METABOLIC
   SYNDROME; SWEETENED BEVERAGES; VISCERAL ADIPOSITY; LIPID-ACCUMULATION
AB The excessive intake of fructose in the regular human diet could be related to global increases in metabolic disorders. Sugar-sweetened soft drinks, mostly consumed by children, adolescents, and young adults, are the main source of added fructose. Dietary high-fructose can increase intestinal permeability and circulatory endotoxin by changing the gut barrier function and microbial composition. Excess fructose transports to the liver and then triggers inflammation as well as de novo lipogenesis leading to hepatic steatosis. Fructose also induces fat deposition in adipose tissue by stimulating the expression of lipogenic genes, thus causing abdominal adiposity. Activation of the inflammatory pathway by fructose in target tissues is thought to contribute to the suppression of the insulin signaling pathway producing systemic insulin resistance. Moreover, there is some evidence that high intake of fructose negatively affects both male and female reproductive systems and may lead to infertility. This review addresses dietary high-fructose-induced deteriorations that are obvious, especially in gut permeability, microbiota, abdominal fat accumulation, insulin signaling, and reproductive function. The recognition of the detrimental effects of fructose and the development of relevant new public health policies are necessary in order to prevent diet-related metabolic disorders.
C1 [Guney, Ceren; Bal, Nur Banu; Akar, Fatma] Gazi Univ, Fac Pharm, Dept Pharmacol, TR-06330 Ankara, Turkiye.
C3 Gazi University
RP Akar, F (corresponding author), Gazi Univ, Fac Pharm, Dept Pharmacol, TR-06330 Ankara, Turkiye.
EM cerennguney@gmail.com; nurbanubal@gazi.edu.tr; fakar@gazi.edu.tr
RI Bal, Nur Banu/AHE-2262-2022; Güney, Ceren/AAK-4075-2021; Akar,
   Fatma/D-1650-2018
OI Akar, Fatma/0000-0002-5432-0304; GUNEY, Ceren/0000-0002-3267-2886; Bal,
   Nur Banu/0000-0001-7865-0917
FU Gazi University Research Fund [BAP 02/201720, BAP 02/201814,
   TDK-2022-7661]
FX This work was supported in part by grants from the Gazi University
   Research Fund. BAP 02/2017-20, BAP 02/2018-14 and TDK-2022-7661.
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NR 248
TC 23
Z9 23
U1 6
U2 33
PU CELL PRESS
PI CAMBRIDGE
PA 50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA
EI 2405-8440
J9 HELIYON
JI Heliyon
PD AUG
PY 2023
VL 9
IS 8
AR e18896
DI 10.1016/j.heliyon.2023.e18896
EA AUG 2023
PG 20
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA Q1MU7
UT WOS:001055237000001
PM 37636431
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Sakr, HF
   Sirasanagandla, SR
   Das, S
   Bima, AI
   Elsamanoudy, AZ
AF Sakr, Hussein F.
   Sirasanagandla, Srinivasa Rao
   Das, Srijit
   Bima, Abdulhadi I.
   Elsamanoudy, Ayman Z.
TI Insulin Resistance and Hypertension: Mechanisms Involved and Modifying
   Factors for Effective Glucose Control
SO BIOMEDICINES
LA English
DT Review
DE hypertension; insulin; resistance; diet; mechanism
ID GLYCATION END-PRODUCTS; FATTY-ACID LEVELS; ARTERIAL STIFFNESS; METABOLIC
   SYNDROME; OXIDATIVE STRESS; SKELETAL-MUSCLE; LINOLEIC-ACID;
   RISK-FACTORS; PHOSPHATIDYLINOSITOL 3-KINASE; TYROSINE PHOSPHORYLATION
AB Factors such as aging, an unhealthy lifestyle with decreased physical activity, snacking, a standard Western diet, and smoking contribute to raising blood pressure to a dangerous level, increasing the risk of coronary artery disease and heart failure. Atherosclerosis, or aging of the blood vessels, is a physiological process that has accelerated in the last decades by the overconsumption of carbohydrates as the primary sources of caloric intake, resulting in increased triglycerides and VLDL-cholesterol and insulin spikes. Classically, medications ranging from beta blockers to angiotensin II blockers and even calcium channel blockers were used alone or in combination with lifestyle modifications as management tools in modern medicine to control arterial blood pressure. However, it is not easy to control blood pressure or the associated complications. A low-carbohydrate, high-fat (LCHF) diet can reduce glucose and insulin spikes, improve insulin sensitivity, and lessen atherosclerosis risk factors. We reviewed articles describing the etiology of insulin resistance (IR) and its impact on arterial blood pressure from databases including PubMed, PubMed Central, and Google Scholar. We discuss how the LCHF diet is beneficial to maintaining arterial blood pressure at normal levels, slowing down the progression of atherosclerosis, and reducing the use of antihypertensive medications. The mechanisms involved in IR associated with hypertension are also highlighted.
C1 [Sakr, Hussein F.] Sultan Qaboos Univ, Coll Med & Hlth Sci, Dept Physiol, Muscat 123, Oman.
   [Sirasanagandla, Srinivasa Rao; Das, Srijit] Sultan Qaboos Univ, Coll Med & Hlth Sci, Dept Human & Clin Anat, Muscat 123, Oman.
   [Bima, Abdulhadi I.; Elsamanoudy, Ayman Z.] King Abdulaziz Univ, Fac Med, Dept Clin Biochem, Jeddah 21465, Saudi Arabia.
C3 Sultan Qaboos University; Sultan Qaboos University; King Abdulaziz
   University
RP Sakr, HF (corresponding author), Sultan Qaboos Univ, Coll Med & Hlth Sci, Dept Physiol, Muscat 123, Oman.
EM hsakr@squ.edu.om; srinivasa@squ.edu.om; s.das@squ.edu.om;
   hadibima@hotmail.com; ayman.elsamanoudy@gmail.com
RI Sirasanagandla, Srinivasa/AAT-8366-2021; Sakr, Hussein/O-4888-2018; Das,
   Srijit/E-8457-2017; Elsamanoudy, Ayman/M-6529-2018
OI Elsamanoudy, Ayman/0000-0002-8731-6184; Sirasanagandla, Srinivasa
   Rao/0000-0002-7261-1666; Das, Srijit/0000-0001-8302-7257
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NR 179
TC 13
Z9 14
U1 0
U2 7
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2227-9059
J9 BIOMEDICINES
JI Biomedicines
PD AUG
PY 2023
VL 11
IS 8
AR 2271
DI 10.3390/biomedicines11082271
PG 22
WC Biochemistry & Molecular Biology; Medicine, Research & Experimental;
   Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Research & Experimental Medicine;
   Pharmacology & Pharmacy
GA Q4ZK9
UT WOS:001057617100001
PM 37626767
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Pelczynska, M
   Moszak, M
   Wesolek, A
   Bogdanski, P
AF Pelczynska, Marta
   Moszak, Malgorzata
   Wesolek, Agnieszka
   Bogdanski, Pawel
TI The Preventive Mechanisms of Bioactive Food Compounds against
   Obesity-Induced Inflammation
SO ANTIOXIDANTS
LA English
DT Review
DE inflammation; obesity; bioactive food compounds; polyphenols; omega-3
   fatty acids; probiotics
ID ADIPOSE-TISSUE INFLAMMATION; ALPHA-LINOLENIC ACID; POLYUNSATURATED
   FATTY-ACIDS; DIET-INDUCED OBESITY; GREEN TEA CATECHINS; C-REACTIVE
   PROTEIN; OXIDATIVE STRESS; METABOLIC SYNDROME; INHIBITS ADIPOGENESIS;
   INSULIN SENSITIVITY
AB Dietary patterns are promising strategies for preventing and treating obesity and its coexisting inflammatory processes. Bioactive food compounds have received considerable attention due to their actions against obesity-induced inflammation, with limited harmful side effects. They are perceived as food ingredients or dietary supplements other than those necessary to meet basic human nutritional needs and are responsible for positive changes in the state of health. These include polyphenols, unsaturated fatty acids, and probiotics. Although the exact mechanisms of bioactive food compounds' action are still poorly understood, studies have indicated that they involve the modulation of the secretion of proinflammatory cytokines, adipokines, and hormones; regulate gene expression in adipose tissue; and modify the signaling pathways responsible for the inflammatory response. Targeting the consumption and/or supplementation of foods with anti-inflammatory potential may represent a new approach to obesity-induced inflammation treatment. Nevertheless, more studies are needed to evaluate strategies for bioactive food compound intake, especially times and doses. Moreover, worldwide education about the advantages of bioactive food compound consumption is warranted to limit the consequences of unhealthy dietary patterns. This work presents a review and synthesis of recent data on the preventive mechanisms of bioactive food compounds in the context of obesity-induced inflammation.
C1 [Pelczynska, Marta; Moszak, Malgorzata; Wesolek, Agnieszka; Bogdanski, Pawel] Poznan Univ Med Sci, Chair & Dept Treatment Obes Metab Disorders & Clin, 84 Szamarzewskiego St, PL-60569 Poznan, Poland.
   [Wesolek, Agnieszka] Poznan Univ Med Sci, Doctoral Sch, 10 Fredry St, PL-61701 Poznan, Poland.
C3 Poznan University of Medical Sciences; Poznan University of Medical
   Sciences
RP Pelczynska, M (corresponding author), Poznan Univ Med Sci, Chair & Dept Treatment Obes Metab Disorders & Clin, 84 Szamarzewskiego St, PL-60569 Poznan, Poland.
EM mpelczynska@ump.edu.pl
RI Pelczyńska, Marta/JZC-7629-2024; Moszak, Małgorzata/GLS-2107-2022;
   Bogdański, Paweł/ABB-2938-2020
OI Bogdanski, Pawel/0000-0002-0563-1624; Pelczynska,
   Marta/0000-0003-4548-032X; Moszak, Malgorzata/0000-0002-8965-6123
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NR 222
TC 12
Z9 12
U1 3
U2 19
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD JUN
PY 2023
VL 12
IS 6
AR 1232
DI 10.3390/antiox12061232
PG 30
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA K0ZR2
UT WOS:001013819400001
PM 37371961
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Kosmas, CE
   Bousvarou, MD
   Kostara, CE
   Papakonstantinou, EJ
   Salamou, E
   Guzman, E
AF Kosmas, Constantine E.
   Bousvarou, Maria D.
   Kostara, Christina E.
   Papakonstantinou, Evangelia J.
   Salamou, Evdokia
   Guzman, Eliscer
TI Insulin resistance and cardiovascular disease
SO JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
LA English
DT Review
DE Insulin; insulin resistance; inflammation; dyslipidemia; oxidative
   stress; endothelial dysfunction; hypertension; cardiovascular disease
ID PLASMINOGEN-ACTIVATOR INHIBITOR-1; POLYCYSTIC-OVARY-SYNDROME; TYPE-2
   DIABETES-MELLITUS; GLUCAGON-LIKE PEPTIDE-1; ANGIOTENSIN-ALDOSTERONE
   SYSTEM; CORONARY-HEART-DISEASE; HEPATOKINES FETUIN-A; METABOLIC
   SYNDROME; ADIPOSE-TISSUE; NITRIC-OXIDE
AB Insulin resistance (IR) and cardiovascular disease (CVD) represent two universal public health hazards, especially in today's Western societies. A causal-effect relationship has been established that links IR with CVD. The mediating mechanisms are perplexing, under ongoing, rigorous investigation and remain to be fully elucidated. IR is a condition encompassing hyperglycemia and compensatory hyperinsulinemia. It occurs when insulin is not capable of exerting its maximum effects on target tissues, including skeletal muscles, liver and adipose tissue. This alteration of insulin signaling pathways results in the development of cardiometabolic disorders, including obesity, dyslipidemia, low-grade inflammation, endothelial dysfunction and hypertension, all of which are predisposing factors for atherosclerosis and CVD. The management of IR can be achieved through dietary modifications, the inclusion of regular exercise routines in everyday life, pharmacological agents and other interventions tailored to each individual patient's needs. It is important to underline though that, although various antidiabetic drugs that may improve IR are available, no medications are as yet specifically approved for the treatment of IR. This narrative review will focus on the current scientific and clinical evidence pertaining to IR, the mechanisms connecting IR with CVD, as well as plausible strategies for a holistic, personalized approach for IR management.
C1 [Kosmas, Constantine E.; Guzman, Eliscer] Montefiore Med Ctr, Dept Med, Div Cardiol, Bronx, NY USA.
   [Bousvarou, Maria D.] Univ Crete, Sch Med, Iraklion, Greece.
   [Kostara, Christina E.] Univ Ioannina, Fac Med, Sch Hlth Sci, Med Dept, Ioannina, Greece.
   [Papakonstantinou, Evangelia J.] Gen Directorate Publ Hlth & Social Welf, Athens, Attica, Greece.
   [Salamou, Evdokia] Athens Bioclin, Athens, Greece.
   [Kosmas, Constantine E.] Cardiol Unltd PC, 629 West 185th St, New York, NY 10033 USA.
C3 Montefiore Medical Center; Albert Einstein College of Medicine;
   University of Crete; University of Ioannina
RP Kosmas, CE (corresponding author), Cardiol Unltd PC, 629 West 185th St, New York, NY 10033 USA.
EM cekosmas1@gmail.com
RI Kosmas, Constantine/ABD-1200-2020; Kostara, Christina/ABH-1348-2020
OI Kostara, Christina/0000-0001-7045-1323; Kosmas,
   Constantine/0000-0003-3926-0304
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NR 266
TC 125
Z9 125
U1 13
U2 44
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0300-0605
EI 1473-2300
J9 J INT MED RES
JI J. Int. Med. Res.
PD MAR
PY 2023
VL 51
IS 3
AR 03000605231164548
DI 10.1177/03000605231164548
PG 49
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA C3ME4
UT WOS:000960989200001
PM 36994866
OA gold, Green Published
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Ngcobo, SR
   Nkambule, BB
   Nyambuya, TM
   Mokgalaboni, K
   Ntsethe, A
   Mxinwa, V
   Ziqubu, K
   Ntamo, Y
   Nyawo, TA
   Dludla, P
AF Ngcobo, Siphamandla R.
   Nkambule, Bongani B.
   Nyambuya, Tawanda M.
   Mokgalaboni, Kabelo
   Ntsethe, Aviwe
   Mxinwa, Vuyolwethu
   Ziqubu, Khanyisani
   Ntamo, Yonela
   Nyawo, Thembeka A.
   Dludla, Phiwayinkosi, V
TI Activated monocytes as a therapeutic target to attenuate vascular
   inflammation and lower cardiovascular disease-risk in patients with type
   2 diabetes: A systematic review of preclinical and clinical studies
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Review
DE Type 2 diabetes; Cardiovascular disease; Vascular function; Monocytes;
   Inflammation; Therapeutic target
ID CORONARY-ARTERY-DISEASE; OXIDATIVE STRESS; SUPPLEMENTATION DECREASES;
   HYPERTENSIVE PATIENTS; METABOLIC SYNDROME; BLOOD-PRESSURE; OBESITY;
   MELLITUS; MARKERS; ATHEROSCLEROSIS
AB Low grade inflammation is associated with the progression of atherosclerosis. Patients with type 2 diabetes (T2D) have altered cholesterol levels, which are targeted by free radicals to promote lipid peroxidation. Elevated levels of monocyte-associated cytokines such as interleukin (IL)-6, monocyte chemoattractant protein 1 (MCP-1), nuclear factor kappa-light-chain-enhancer of activated B cells (NF-Kappa B), and tumor necrosis factor-alpha (TNF-alpha), subsequently drive endothelial tissue injury. In fact, the levels of circulating platelet-monocyte aggregates in patients with T2D is a robust marker for atherosclerosis and a cardiovascular disease (CVD)-risk factor. To identify eligible studies, we searched the major online databases using PubMed and Google Scholar. The cumulative evidence synthesized in the current review suggests that, traditional therapies which include thiazolidinediones, statins and some calcium channel blockers can be useful in the primary prevention of atherosclerosis by inhibiting the formation of monocyte-derived microparticles, and pro-inflammatory cytokines such as IL-6, TNF-alpha, MCP-1, and NF-Kappa B in patients with T2D. Future studies are needed to ascertain whether the combination of dietary interventions and glucose or lipid lowering agents can provide an enhanced cardioprotection in patients with T2D.
C1 [Ngcobo, Siphamandla R.; Nkambule, Bongani B.; Mokgalaboni, Kabelo; Ntsethe, Aviwe; Mxinwa, Vuyolwethu] Univ KwaZulu Natal, Sch Lab Med & Med Sci, ZA-4000 Durban, South Africa.
   [Nyambuya, Tawanda M.] Namibia Univ Sci & Technol, Dept Hlth Sci, Windhoek 9000, Namibia.
   [Ziqubu, Khanyisani] North West Univ, Dept Biochem, ZA-2745 Mmabatho, South Africa.
   [Ntamo, Yonela; Nyawo, Thembeka A.; Dludla, Phiwayinkosi, V] South African Med Res Council, Biomed Res & Innovat Platform, POB 19070, ZA-7505 Tygerberg, South Africa.
   [Nyawo, Thembeka A.] Stellenbosch Univ, Fac Med & Hlth Sci, Div Med Physiol, Ctr Cardiometab Res Africa CARMA, ZA-7505 Tygerberg, South Africa.
C3 University of Kwazulu Natal; Namibia University of Science & Technology;
   North West University - South Africa; South African Medical Research
   Council; Stellenbosch University
RP Dludla, P (corresponding author), South African Med Res Council, Biomed Res & Innovat Platform, POB 19070, ZA-7505 Tygerberg, South Africa.
RI Nyambuya, Tawanda Maurice/GLU-4124-2022; Nkambule,
   Bongani/ABD-7943-2022; Mokgalaboni, Kabelo/ACZ-1282-2022; Ngcobo,
   Siphamandla/JGM-4215-2023
OI Mokgalaboni, Kabelo/0000-0002-3224-7433; Nyambuya, Tawanda
   Maurice/0000-0002-3288-9524; Ngcobo, Siphamandla/0000-0002-7560-8526;
   Nkambule, Bongani/0000-0001-8846-1992
FU National Research Foundation of South Africa (NRF) [107519]; NIH D43
   Grant [D43TW010131]
FX SR Ngcobo and BB Nkambule are partially funded by the National Research
   Foundation of South Africa (NRF, Grant no: 107519). BB Nkambule is also
   the University of KwaZulu Natal (UKZN) Developing Research Innovation,
   Localization and Leadership in South Africa (DRILL) fellow. DRILL is an
   NIH D43 Grant (D43TW010131) awarded to UKZN in 2015 to support a
   research training and induction program for early-career academics. The
   grant holders acknowledge that the findings, opinions and conclusions or
   recommendations arrived at in this manuscript are those of the authors
   and that funders have no influence in the writing and preparation of the
   manuscript.
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NR 98
TC 15
Z9 15
U1 0
U2 3
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD FEB
PY 2022
VL 146
AR 112579
DI 10.1016/j.biopha.2021.112579
PG 11
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA ZI5RV
UT WOS:000761679200001
PM 35062054
OA gold
DA 2025-06-11
ER

PT J
AU Andreadou, I
   Efentakis, P
   Frenis, K
   Daiber, A
   Schulz, R
AF Andreadou, Ioanna
   Efentakis, Panagiotis
   Frenis, Katie
   Daiber, Andreas
   Schulz, Rainer
TI Thiol-based redox-active proteins as cardioprotective therapeutic agents
   in cardiovascular diseases
SO BASIC RESEARCH IN CARDIOLOGY
LA English
DT Review
DE Thioredoxins; Glutaredoxins; Peroxiredoxins; Cardiac hypertrophy;
   Ischemia; reperfusion injury; Heart failure
ID ISCHEMIA-REPERFUSION INJURY; MITOCHONDRIAL PEROXIREDOXIN-3 PROTECTS;
   ACUTE MYOCARDIAL-INFARCTION; NA+-K+ PUMP; OXIDATIVE STRESS;
   HYDROGEN-PEROXIDE; ISCHEMIA/REPERFUSION INJURY; PROTEOMIC ANALYSIS;
   UP-REGULATION; MAMMALIAN THIOREDOXIN
AB Thiol-based redox compounds, namely thioredoxins (Trxs), glutaredoxins (Grxs) and peroxiredoxins (Prxs), stand as a pivotal group of proteins involved in antioxidant processes and redox signaling. Glutaredoxins (Grxs) are considered as one of the major families of proteins involved in redox regulation by removal of S-glutathionylation and thereby reactivation of other enzymes with thiol-dependent activity. Grxs are also coupled to Trxs and Prxs recycling and thereby indirectly contribute to reactive oxygen species (ROS) detoxification. Peroxiredoxins (Prxs) are a ubiquitous family of peroxidases, which play an essential role in the detoxification of hydrogen peroxide, aliphatic and aromatic hydroperoxides, and peroxynitrite. The Trxs, Grxs and Prxs systems, which reversibly induce thiol modifications, regulate redox signaling involved in various biological events in the cardiovascular system. This review focuses on the current knowledge of the role of Trxs, Grxs and Prxs on cardiovascular pathologies and especially in cardiac hypertrophy, ischemia/reperfusion (I/R) injury and heart failure as well as in the presence of cardiovascular risk factors, such as hypertension, hyperlipidemia, hyperglycemia and metabolic syndrome. Further studies on the roles of thiol-dependent redox systems in the cardiovascular system will support the development of novel protective and therapeutic strategies against cardiovascular diseases.
C1 [Andreadou, Ioanna; Efentakis, Panagiotis] Natl & Kapodistrian Univ Athens, Lab Pharmacol, Fac Pharm, Athens, Greece.
   [Frenis, Katie; Daiber, Andreas] Johannes Gutenberg Univ Mainz, Dept Cardiol 1 Mol Cardiol, Univ Med Ctr, Langenbeckstr 1, D-55131 Mainz, Germany.
   [Daiber, Andreas] German Ctr Cardiovascular Res DZHK, Partner Site Rhine Main, Langenbeckstr 1, D-55131 Mainz, Germany.
   [Schulz, Rainer] Justus Liebig Univ Giessen, Inst Physiol, Giessen, Germany.
C3 National & Kapodistrian University of Athens; Johannes Gutenberg
   University of Mainz; German Centre for Cardiovascular Research; Justus
   Liebig University Giessen
RP Andreadou, I (corresponding author), Natl & Kapodistrian Univ Athens, Lab Pharmacol, Fac Pharm, Athens, Greece.
EM jandread@pharm.uoa.gr; rainer.schulz@physiologie.med.uni-giessen.de
RI Frenis, Katie/AAA-5161-2022; Andreadou, Ioanna/AAF-7284-2019; Schulz,
   Rainer/ABD-5069-2021; Efentakis, Panagiotis/ABG-3175-2021; Daiber,
   Andreas/HJY-5274-2023
OI Schulz, Rainer/0000-0003-3017-0476; Frenis, Katie/0000-0003-4103-0882
FU EU-CARDIOPROTECTION COST (European Cooperation in Science and
   Technology-Action) [CA16225]; European Union (ERDF) [5048539]; Greek
   national funds through the Operational Program "Competitiveness,
   Entrepreneurship and Innovation", under the call "RESEARCH -CREATE
   -INNOVATE" [5048539]; Boehringer Ingelheim Foundation; Deutsche
   Forschungsgemeinschaft (DFG, German Research Foundation) [268555672 -SFB
   1213]
FX This work has been supported by the EU-CARDIOPROTECTION COST (European
   Cooperation in Science and Technology-Action) (CA16225). I.A.
   acknowledges support from the European Union (ERDF) and Greek national
   funds through the Operational Program "Competitiveness, Entrepreneurship
   and Innovation", under the call "RESEARCH -CREATE -INNOVATE" (Project
   code: 5048539). A. D. was supported by vascular biology research grants
   from the Boehringer Ingelheim Foundation for the collaborative research
   group 'Novel and neglected cardiovascular risk factors: Molecular
   mechanisms and therapeutics'. R.S. was supported by Deutsche
   Forschungsgemeinschaft (DFG, German Research Foundation) [Project number
   268555672 -SFB 1213, Project B05].
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NR 265
TC 31
Z9 34
U1 1
U2 34
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0300-8428
EI 1435-1803
J9 BASIC RES CARDIOL
JI Basic Res. Cardiol.
PD DEC
PY 2021
VL 116
IS 1
AR 44
DI 10.1007/s00395-021-00885-5
PG 32
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA TJ8CX
UT WOS:000673703800001
PM 34275052
DA 2025-06-11
ER

PT J
AU Park, JY
   Jang, MG
   Oh, JM
   Ko, HC
   Hur, SP
   Kim, JW
   Baek, S
   Kim, SJ
AF Park, Jeong Yong
   Jang, Mi Gyeong
   Oh, Jung Min
   Ko, Hee Chul
   Hur, Sung-Pyo
   Kim, Jae-Won
   Baek, Songyee
   Kim, Se-Jae
TI Sasa quelpaertensis Leaf Extract Ameliorates Dyslipidemia,
   Insulin Resistance, and Hepatic Lipid Accumulation in
   High-Fructose-Diet-Fed Rats
SO NUTRIENTS
LA English
DT Article
DE Sasa quelpaertensis; dyslipidemia; high-fructose diet; insulin
   resistance; metabolic dysfunction
ID METABOLIC SYNDROME; ANTIOXIDANT ACTIVITY; GLUCOSE; FAT; SENSITIVITY;
   SUPPRESSES; EXPRESSION; STRINGTIE; STRESS; HISAT
AB Background: Increased dietary fructose consumption is closely associated with lipid and glucose metabolic disorders. Sasa quelpaertensis Nakai possesses various health-promoting properties, but there has been no research on its protective effect against fructose-induced metabolic dysfunction. In this study, we investigated the effects of S. quelpaertensis leaf extract (SQE) on metabolic dysfunction in high-fructose-diet-fed rats. Methods: Animals were fed a 46% carbohydrate diet, a 60% high-fructose diet, or a 60% high-fructose diet with SQE (500 mg/kg of body weight (BW)/day) in drinking water for 16 weeks. Serum biochemical parameters were measured and the effects of SQE on hepatic histology, protein expression, and transcriptome profiles were investigated. Results: SQE improved dyslipidemia and insulin resistance induced in high-fructose-diet-fed rats. SQE ameliorated the lipid accumulation and inflammatory response in liver tissues by modulating the expressions of key proteins related to lipid metabolism and antioxidant response. SQE significantly enriched the genes related to the metabolic pathway, namely, the tumor necrosis factor (TNF) signaling pathway and the PI3K-Akt signaling pathway. Conclusions: SQE could effectively prevent dyslipidemia, insulin resistance, and hepatic lipid accumulation by regulation of metabolism-related gene expressions, suggesting its role as a functional ingredient to prevent lifestyle-related metabolic disorders.
C1 [Park, Jeong Yong; Jang, Mi Gyeong; Oh, Jung Min; Kim, Se-Jae] Jeju Natl Univ, Dept Biol, Jeju 63243, South Korea.
   [Ko, Hee Chul; Kim, Jae-Won; Baek, Songyee; Kim, Se-Jae] Jeju Nat Univ, Biotech Reg Innovat Ctr, Jeju 63423, South Korea.
   [Hur, Sung-Pyo] Korea Inst Ocean Sci & Technol, Jeju Int Marine Sci Res & Logist Ctr, Gujwa 63349, Jeju, South Korea.
C3 Jeju National University; Jeju National University; Korea Institute of
   Ocean Science & Technology (KIOST)
RP Kim, SJ (corresponding author), Jeju Natl Univ, Dept Biol, Jeju 63243, South Korea.; Kim, SJ (corresponding author), Jeju Nat Univ, Biotech Reg Innovat Ctr, Jeju 63423, South Korea.
EM jjjoosd@naver.com; mkjang@jejunu.ac.kr; ojh554@naver.com;
   ifly1007@jejunu.ac.kr; hursp@kiost.ac.kr; kjw8839@jejunu.ac.kr;
   summerbee@jejunu.ac.kr; sjkim@jejunu.ac.kr
OI Hur, Sung-Pyo/0000-0002-1622-3271; Ko, Hee Chul/0000-0002-0222-6658
FU National Research Foundation of Korea (NRF) by Ministry of Education
   [2020R1I1A3A04037169]; 2020 Scientific Promotion Program - Jeju National
   University
FX This study was supported by the Basic Science Research Program through
   the National Research Foundation of Korea (NRF) by the Ministry of
   Education (2020R1I1A3A04037169) and the 2020 Scientific Promotion
   Program funded by Jeju National University.
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NR 43
TC 2
Z9 3
U1 0
U2 2
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD DEC
PY 2020
VL 12
IS 12
AR 3762
DI 10.3390/nu12123762
PG 17
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA PK5XU
UT WOS:000602518300001
PM 33297496
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Song, J
   He, YN
   Luo, CH
   Feng, B
   Ran, F
   Xu, H
   Ci, ZM
   Xu, RC
   Han, L
   Zhang, DK
AF Song, Jiao
   He, Yanan
   Luo, Chuanhong
   Feng, Bi
   Ran, Fei
   Xu, Hong
   Ci, Zhimin
   Xu, Runchun
   Han, Li
   Zhang, Dingkun
TI New progress in the pharmacology of protocatechuic acid: A compound
   ingested in daily foods and herbs frequently and heavily
SO PHARMACOLOGICAL RESEARCH
LA English
DT Review
DE Protocatechuic acid; Pharmacology; Pharmacokinetics; Toxicology
ID NF-KAPPA-B; SIMPLE PHENOLIC ANTIOXIDANT; GLYCATION END-PRODUCTS;
   SPINAL-CORD-INJURY; UHPLC-MS/MS METHOD; OXIDATIVE STRESS; IN-VITRO;
   ANTIBACTERIAL ACTIVITY; CELL-PROLIFERATION; ROSELLE CALYX
AB Protocatechuic acid is a natural phenolic acid, which widely exists in our daily diet and herbs. It is also one of the main metabolites of complex polyphenols, such as anthocyanins and proanthocyanins. In recent years, a large number of studies on the pharmacological activities of protocatechuic acid have emerged. Protocatechuic acid has a wide range of pharmacological activities including antioxidant, anti-inflammatory, neuroprotective, antibacterial, antiviral, anticancer, antiosteoporotic, analgesia, antiaging activties; protection from metabolic syndrome; and preservation of liver, kidneys, and reproductive functions. Pharmacokinetic studies showed that the absorption and elimination rate of protocatechuic acid are faster, with glucuronidation and sulfation being the major metabolic pathways. However, protocatechuic acid displays a dual-directional regulatory effect on some pharmacological activities. When the concentration is very high, it can inhibit cell proliferation and reduce survival rate. This review aims to comprehensively summarize the pharmacology, pharmacokinetics, and toxicity of protocatechuic acid with emphasis on its pharmacological activities discovered in recent 5 years, so as to provide more up-to-date and thorough information for the preclinical and clinical research of protocatechuic acid in the future. Moreover, it is hoped that the clinical application of protocatechuic acid can be broadened, giving full play to its characteristics of rich sources, low toxicity and wide pharmacological activites.
C1 [Song, Jiao; He, Yanan; Luo, Chuanhong; Feng, Bi; Ran, Fei; Ci, Zhimin; Xu, Runchun; Han, Li; Zhang, Dingkun] Chengdu Univ Tradit Chinese Med, Pharm Coll, Key Lab Breeding Base Systemat Res & Utilizat Chi, Chengdu 611137, Peoples R China.
   [Xu, Hong] Chengdu Yongkang Pharmaceut Co Ltd, Chengdu 610041, Peoples R China.
C3 Chengdu University of Traditional Chinese Medicine
RP Han, L; Zhang, DK (corresponding author), Chengdu Univ Tradit Chinese Med, Pharm Coll, Key Lab Breeding Base Systemat Res & Utilizat Chi, Chengdu 611137, Peoples R China.
EM hanliyx@163.com; zhangdingkun@cdutcm.edu.cn
RI Zhang, Ding-kun/AAF-1142-2020
FU National Natural Science Foudation of China [81873232, 81274098]
FX The author gratefully acknowledge the financial support by the National
   Natural Science Foudation of China (81873232, 81274098).
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NR 201
TC 181
Z9 189
U1 25
U2 180
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 1043-6618
EI 1096-1186
J9 PHARMACOL RES
JI Pharmacol. Res.
PD NOV
PY 2020
VL 161
AR 105109
DI 10.1016/j.phrs.2020.105109
PG 25
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA PI3JG
UT WOS:000600990100012
PM 32738494
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Tavare, JF
   Ribeiro, PVM
   Coelho, OGL
   da Silva, LE
   Alfenas, RCG
AF Tavare, Julisana F.
   Ribeiro, Priscila V. M.
   Coelho, Olivia G. L.
   da Silva, Lais E.
   Alfenas, Rita C. G.
TI Can advanced glycation end-products and their receptors be affected by
   weight loss? A systematic review
SO OBESITY REVIEWS
LA English
DT Review
DE advanced glycation end product; bariatric surgery; caloric restriction;
   overweight; sRAGE
ID ENDOGENOUS SECRETORY RECEPTOR; CIRCULATING SOLUBLE RECEPTOR; LOW-CALORIE
   DIET; METABOLIC SYNDROME; OXIDATIVE STRESS; INSULIN SENSITIVITY;
   BARIATRIC SURGERY; SERUM-LEVELS; N-EPSILON-(CARBOXYMETHYL) LYSINE;
   GLYCOXIDATION PRODUCTS
AB Advanced glycation end products (AGEs) have been implicated in the pathogenesis of most chronic diseases. Therefore, identification of treatments that can attenuate the effects of these compounds and prevent cardiometabolic complications is of extreme public health interest. Recently, body weight management interventions showed positive results on reducing serum AGE concentrations. Moreover, the soluble receptor for advanced glycation end products (sRAGE) is considered to be a novel biomarker to identify patients with obesity most likely to benefit from weight management interventions. This systematic review aimed to critically analyze papers evaluating the effects of weight loss on serum AGEs and its receptors in adults with excess body weight. MEDLINE, Cochrane, Scopus, and Lilacs databases were searched. Three studies evaluating the response of AGEs to energy-restricted diets and six assessing sRAGE as the primary outcome were included. Energy-restricted diets and bariatric surgery reduced serum AGE concentrations, but effects on endogenous secretory RAGE (esRAGE) and sRAGE concentrations are conflicting. These results may be associated with mechanisms related to changes in dietary intake and limiting endogenous AGE formation. Therefore, the role of energy-restricted diets and bariatric surgery on lowering serum AGE concentrations, as well as its effects on AGEs receptors, deserves further investigation.
C1 [Tavare, Julisana F.; Ribeiro, Priscila V. M.; Coelho, Olivia G. L.; da Silva, Lais E.; Alfenas, Rita C. G.] Univ Fed Vicosa, Dept Nutr & Saude, Ave PH Rolfs S-N, BR-36570900 Vicosa, MG, Brazil.
C3 Universidade Federal de Vicosa
RP Tavare, JF (corresponding author), Univ Fed Vicosa, Dept Nutr & Saude, Ave PH Rolfs S-N, BR-36570900 Vicosa, MG, Brazil.
EM julianaftavares@outlook.com
RI de Melo Ribeiro, Priscila/AAO-8190-2020
OI Alfenas, Rita/0000-0003-2290-1611
FU Conselho Nacional de Desenvolvimento Cientifico e Tecnologico;
   Coordenacao de Aperfeicoamento de Pessoal de Ensino Superior; Fundacao
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NR 77
TC 18
Z9 18
U1 1
U2 14
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1467-7881
EI 1467-789X
J9 OBES REV
JI Obes. Rev.
PD JUN
PY 2020
VL 21
IS 6
DI 10.1111/obr.13000
EA JAN 2020
PG 13
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA LO1YK
UT WOS:000507483600001
PM 31950676
DA 2025-06-11
ER

PT J
AU Lu, CR
   Xie, TY
   Guo, X
   Wu, D
   Li, S
   Li, XG
   Lu, YX
   Wang, XX
AF Lu, Canrong
   Xie, Tianyu
   Guo, Xin
   Wu, Di
   Li, Shuo
   Li, Xiongguang
   Lu, Yixun
   Wang, Xinxin
TI Glucagon-like peptide-1 receptor agonist exendin-4 mitigates
   lipopolysaccharide-induced inflammatory responses in RAW264.7
   macrophages
SO INTERNATIONAL IMMUNOPHARMACOLOGY
LA English
DT Article
DE Inflammatory response; Macrophage; Exendin-4; JNK; NF-kappa B; AP-1;
   iNOS; PGE2
ID NF-KAPPA-B; NITRIC-OXIDE; SIGNAL-TRANSDUCTION; METABOLIC SYNDROME;
   ACTIVATION; OBESITY; SUPPRESSION; INHIBITION; EXPRESSION; CYTOKINE
AB Macrophages play a critical role in the immune response against pathogen invasion and injury. However, under pathological stress, macrophages could have aberrant roles and contribute to the pathogenesis of inflammatory associated diseases. Exenatide is a glucagon-like peptide 1(GLP-1) agonist, which belongs to the family of synthetic exendin-based incretin mimetic. Exendin related compounds reduce glucose levels in type 2 diabetes patients. The purpose of this study was to examine the anti-inflammatory effects of exendin-4 in LPS-induced activation of macrophages. We show that exendin-4 inhibits LPS-induced expression of inflammatory mediators (iNOS, COX-2, PGE2 and NO) and pro-inflammatory cytokines (TNF-alpha, IL-1 beta, and IL-6) in RAW264.7 macrophages. Exendin-4 pretreatment mitigates LPS induced cellular ROS production. Mechanistically, Exendin-4 suppresses the LPS-induced activation of the JNK and AP-1 pathway. Furthermore, exendin-4 suppresses both nuclear p65 accumulation and transfected NF-kappa B promoter activity, indicating it inhibits the activation of the NF-kappa B pathway. Our study demonstrates that the GLP-1 agonist exendin-4 has a potent and-inflammatory effect independent on its glucose reducing ability, and exendin-4 has the potential implication to treat inflammatory associated diseases.
C1 [Lu, Canrong; Xie, Tianyu; Guo, Xin; Wu, Di; Li, Shuo; Li, Xiongguang; Lu, Yixun; Wang, Xinxin] Chinese Peoples Liberat Army Gen Hosp, Dept Gen Surg, 28 Fuxing Rd, Beijing 100853, Peoples R China.
C3 Chinese People's Liberation Army General Hospital
RP Wang, XX (corresponding author), Chinese Peoples Liberat Army Gen Hosp, Dept Gen Surg, 28 Fuxing Rd, Beijing 100853, Peoples R China.
EM summer774262@163.com
RI 解, 天宇/HHZ-0134-2022; wang, xinxin/HIR-2598-2022
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NR 28
TC 24
Z9 25
U1 2
U2 9
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1567-5769
EI 1878-1705
J9 INT IMMUNOPHARMACOL
JI Int. Immunopharmacol.
PD DEC
PY 2019
VL 77
AR 105969
DI 10.1016/j.intimp.2019.105969
PG 7
WC Immunology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Pharmacology & Pharmacy
GA JW5NR
UT WOS:000503099100041
PM 31685436
DA 2025-06-11
ER

PT J
AU López-Lluch, G
AF Lopez-Lluch, Guillermo
TI Mitochondrial activity and dynamics changes regarding metabolism in
   ageing and obesity
SO MECHANISMS OF AGEING AND DEVELOPMENT
LA English
DT Article
DE Mitochondria; Ageing; Fat; Gender; Inflammation
ID HUMAN SKELETAL-MUSCLE; PROTEIN-KINASE AMPK; BETA-CELL FUNCTION; CALORIE
   RESTRICTION; INSULIN-RESISTANCE; OXIDATIVE STRESS; ADIPOSE-TISSUE;
   DIRECT PHOSPHORYLATION; REGULATE AUTOPHAGY; ISOMERASE PIN1
AB Mitochondria play an essential role in ageing and longevity. During ageing, a general deregulation of metabolism occurs, affecting molecular, cellular and physiological activities in the organism. Dysfunction of mitochondria has been associated with ageing and age-related diseases indicating their importance in the maintenance of cell homeostasis. Three major nutritional sensors, mTOR, AMPI( and Sirtuins are involved in the control of mitochondrial physiology. These nutritional sensors control mitochondrial biogenesis, dynamics by regulating fusion and fission processes, and turnover through mito- and autophagy. Apart of the known factors involved in fusion, OPA1 and mitofusins, and fission, DRP1 and FIS1, emerging factors such as prohibitins and sestrins can play important functions in mitochondrial dynamics regulation. Mitochondria is also affected by sexual hormones that suffer drastic changes during ageing. The recent literature demonstrates the complex interaction between nutritional sensors and mitochondrial homeostasis in the physiology of adipose tissue and in the accumulation of fat in other organs such as muscle and liver. In this article, the role of mitochondrial homeostasis in ageing and age-dependent fat accumulation is revised. This review highlights the importance of mitochondria in the accumulation of fat during ageing and related diseases such as obesity, metabolic syndrome or type 2 diabetes mellitus. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
C1 [Lopez-Lluch, Guillermo] Univ Pablo Olavide, CABD CSIC, CIBERER, Inst Salud Carlos 3,Dept Fisiol Anatomia & Biol C, Seville 41013, Spain.
C3 Consejo Superior de Investigaciones Cientificas (CSIC); Universidad
   Pablo de Olavide; CSIC - Andalusian Center for Developmental Biology
   (CABD); CIBER - Centro de Investigacion Biomedica en Red; CIBERER
RP López-Lluch, G (corresponding author), Univ Pablo Olavide, CABD, Dept Physiol Anat & Cell Biol, Carretera Utrera Km 1, Seville 41013, Spain.
EM glopllu@upo.es
RI Lopez-Lluch, Guillermo/N-4742-2014
OI Lopez-Lluch, Guillermo/0000-0001-9830-8502
FU Andalusian Government (FEDER funds of European Commission) [BIO177];
   Spanish Ministry of Economy and Competitiveness [DEP2012-39985]
FX The research group is funded by the Andalusian Government grant BIO177
   (FEDER funds of European Commission). Research has been funded by the
   Spanish Ministry of Economy and Competitiveness grant DEP2012-39985.
   Author is also member of the CIBERER, Instituto Carlos III, of the
   Spanish Ministry of Health.
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NR 204
TC 77
Z9 83
U1 2
U2 33
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0047-6374
EI 1872-6216
J9 MECH AGEING DEV
JI Mech. Ageing Dev.
PD MAR
PY 2017
VL 162
BP 108
EP 121
DI 10.1016/j.mad.2016.12.005
PG 14
WC Cell Biology; Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Cell Biology; Geriatrics & Gerontology
GA ER5XJ
UT WOS:000398877300015
PM 27993601
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Fainberg, HP
   Sharkey, D
   Sebert, S
   Wilson, V
   Pope, M
   Budge, H
   Symonds, ME
AF Fainberg, H. P.
   Sharkey, D.
   Sebert, S.
   Wilson, V.
   Pope, M.
   Budge, H.
   Symonds, M. E.
TI Suboptimal maternal nutrition during early fetal kidney development
   specifically promotes renal lipid accumulation following juvenile
   obesity in the offspring
SO REPRODUCTION FERTILITY AND DEVELOPMENT
LA English
DT Article
DE pregnancy; sheep
ID UNFOLDED PROTEIN RESPONSE; NUTRIENT RESTRICTION; ANGIOTENSIN-II;
   ADIPOSE-TISSUE; TUBULAR CELLS; ONSET OBESITY; FATTY RATS; HYPERTENSION;
   EXPRESSION; PREGNANCY
AB Reduced maternal food intake between early-to-mid gestation results in tissue-specific adaptations in the offspring following juvenile-onset obesity that are indicative of insulin resistance. The aim of the present study was to establish the extent to which renal ectopic lipid accumulation, as opposed to other markers of renal stress, such as iron deposition and apoptosis, is enhanced in obese offspring born to mothers nutrient restricted (NR) throughout early fetal kidney development. Pregnant sheep were fed either 100% (control) or NR (i.e. fed 50% of their total metabolisable energy requirement from 30-80 days gestation and 100% at all other times). At weaning, offspring were made obese and, at approximately 1 year, kidneys were sampled. Triglyceride content, HIF-1 alpha gene expression and the protein abundance of the outer-membrane transporter voltage-dependent anion-selective channel protein (VDAC)-I on the kidney cortex were increased in obese offspring born to NR mothers compared with those born to controls, which exhibited increased iron accumulation within the tubular epithelial cells and increased gene expression of the death receptor Fas. In conclusion, suboptimal maternal nutrition coincident with early fetal kidney development results in enhanced renal lipid deposition following juvenile obesity and could accelerate the onset of the adverse metabolic, rather than cardiovascular, symptoms accompanying the metabolic syndrome.
C1 [Fainberg, H. P.; Sharkey, D.; Sebert, S.; Wilson, V.; Pope, M.; Budge, H.; Symonds, M. E.] Univ Nottingham Hosp, Sch Med, Early Life Nutr Res Unit, Nottingham NG7 2UH, England.
C3 University of Nottingham
RP Symonds, ME (corresponding author), Univ Nottingham Hosp, Sch Med, Early Life Nutr Res Unit, Nottingham NG7 2UH, England.
EM michael.symonds@nottingham.ac.uk
RI Fainberg, Hernan/GQZ-6651-2022
OI Sebert, Sylvain/0000-0001-6681-6983; Pope, Mark/0000-0003-4576-7814;
   Sharkey, Don/0000-0002-4989-8697; Fainberg, Hernan
   Pablo/0000-0001-9330-9047; Symonds, Michael/0000-0001-9649-8963;
   Fainberg, Hernan/0000-0003-3742-3165
FU British Heart Foundation Studentship [FS/05/098/19942]; European Union
   Sixth Framework for Research and Technical Development of the European
   Community-The Early Nutrition Programming Project [FOOD-CT-2005-007036];
   Nottingham Respiratory Medicine Biomedical Research Unit; Wellcome Trust
   Value-in-People award
FX This work was support by a British Heart Foundation Studentship (to HPF)
   and Clinical Fellowship (to DS; FS/05/098/19942), the European Union
   Sixth Framework for Research and Technical Development of the European
   Community-The Early Nutrition Programming Project (FOOD-CT-2005-007036)
   and the Nottingham Respiratory Medicine Biomedical Research Unit. SS was
   also supported by a Wellcome Trust Value-in-People award. The authors
   thank Dr D. S. Gardner for his work on the animal rearing,
   instrumentation and the dissection of tissues used in this study.
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DI 10.1071/RD12037
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SC Developmental Biology; Reproductive Biology; Zoology
GA 157GY
UT WOS:000319885400002
PM 22951182
DA 2025-06-11
ER

PT J
AU Li, JM
   Wang, W
   Fan, CY
   Wang, MX
   Zhang, X
   Hu, QH
   Kong, LD
AF Li, Jian-Mei
   Wang, Wei
   Fan, Chen-Yu
   Wang, Ming-Xing
   Zhang, Xian
   Hu, Qing-Hua
   Kong, Ling-Dong
TI Quercetin Preserves β-Cell Mass and Function in Fructose-Induced
   Hyperinsulinemia through Modulating Pancreatic Akt/FoxO1 Activation
SO EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Article
ID FORKHEAD PROTEIN FOXO1; METABOLIC SYNDROME; INSULIN-RECEPTOR;
   AMELIORATES HYPERGLYCEMIA; HEPATIC STEATOSIS; DIETARY FRUCTOSE;
   OXIDATIVE STRESS; URIC-ACID; LEPTIN; TRANSCRIPTION
AB Fructose-induced hyperinsulinemia is associated with insulin compensative secretion and predicts the onset of type 2 diabetes. In this study, we investigated the preservation of dietary flavonoid quercetin on pancreatic beta-cellmass and function in fructose-treated rats and INS-1 beta-cells. Quercetin was confirmed to reduce serum insulin and leptin levels and blockade islet hyperplasia in fructose-fed rats. It also prevented fructose-induced beta-cell proliferation and insulin hypersecretion in INS-1 beta-cells. High fructose increased forkhead box protein O1 (FoxO1) expressions in vivo and in vitro, which were reversed by quercetin. Quercetin downregulated Akt and FoxO1 phosphorylation in fructose-fed rat islets and increased the nuclear FoxO1 levels in fructose-treated INS-1 beta-cells. The elevated Akt phosphorylation in fructose-treated INS-1 beta-cells was also restored by quercetin. Additionally, quercetin suppressed the expression of pancreatic and duodenal homeobox 1 (Pdx1) and insulin gene (Ins1 and Ins2) in vivo and in vitro. In fructose-treated INS-1 beta-cells, quercetin elevated the reduced janus kinase 2/signal transducers and activators of transcription 3 (Jak2/Stat3) phosphorylation and suppressed the increased suppressor of cytokine signaling 3 (Socs3) expression. These results demonstrate that quercetin protects beta-cellmass and function under high-fructose induction through improving leptin signaling and preserving pancreatic Akt/FoxO1 activation.
C1 [Li, Jian-Mei; Wang, Wei; Fan, Chen-Yu; Wang, Ming-Xing; Zhang, Xian; Hu, Qing-Hua; Kong, Ling-Dong] Nanjing Univ, Sch Life Sci, State Key Lab Pharmaceut Biotechnol, Nanjing 210093, Jiangsu, Peoples R China.
C3 Nanjing University
RP Kong, LD (corresponding author), Nanjing Univ, Sch Life Sci, State Key Lab Pharmaceut Biotechnol, Nanjing 210093, Jiangsu, Peoples R China.
EM kongld@nju.edu.cn
RI w, w/J-6981-2019; Fan, Chenyu/KCY-8304-2024; Hu, Qinghua/KJM-2223-2024
FU National Natural Science Foundation of China [NSFC 81025025, 31000763];
   National Basic Research Program of China 973 Program [2012CB517600,
   2012CB517602]; Ph.D. Programs Foundation of Ministry of Education of
   China [20090091120015, 20120091110039]; Natural Science Foundation of
   Jiangsu Province [BK201220103]; Fundamental Research Funds for the
   Central Universities [1095020822]; Program for Changjiang Scholars and
   Innovative Research Team in University [IRT1020]
FX The authors thank Dr. Ding Yin of State Key Laboratory of Analytical
   Chemistry for Life Science of Nanjing University for kindly helping in
   the immunofluorescence staining. This work was supported by National
   Natural Science Foundation of China (NSFC 81025025 and 31000763),
   National Basic Research Program of China 973 Program no. 2012CB517600
   (no. 2012CB517602), Ph.D. Programs Foundation of Ministry of Education
   of China (20090091120015 and 20120091110039), Natural Science Foundation
   of Jiangsu Province (BK201220103), Fundamental Research Funds for the
   Central Universities (1095020822), and Program for Changjiang Scholars
   and Innovative Research Team in University (IRT1020). No potential
   conflict of interests relevant to this paper was reported.
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NR 51
TC 41
Z9 45
U1 0
U2 34
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1741-427X
EI 1741-4288
J9 EVID-BASED COMPL ALT
JI Evid.-based Complement Altern. Med.
PY 2013
VL 2013
AR 303902
DI 10.1155/2013/303902
PG 12
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA 103EW
UT WOS:000315898900001
PM 23533474
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Moraes-Teixeira, JD
   Félix, A
   Fernandes-Santos, C
   Moura, AS
   Mandarim-de-Lacerda, CA
   de Carvalho, JJ
AF Moraes-Teixeira, Jessica de Andrade
   Felix, Alyne
   Fernandes-Santos, Caroline
   Moura, Anibal Sanchez
   Mandarim-de-Lacerda, Carlos Alberto
   de Carvalho, Jorge Jose
TI Exercise training enhances elastin, fibrillin and nitric oxide in the
   aorta wall of spontaneously hypertensive rats
SO EXPERIMENTAL AND MOLECULAR PATHOLOGY
LA English
DT Article
DE Hypertension; Exercise training; Aorta; Elastin; Elastic fiber; Nitric
   oxide
ID SMOOTH-MUSCLE-CELLS; DIASTOLIC FUNCTIONS; METABOLIC SYNDROME;
   PHYSICAL-EXERCISE; PRESSURE; FIBERS; LAMELLAE; ARTERY; STRESS
AB This work aimed to analyze the effect of low-intensity exercise training on ultrastructural and molecular aortic remodeling. Male Wistar-Kyoto rats (WKY) and spontaneously hypertensive rats (SHR) were allocated into four groups: sedentary WKY (SED-WKY), exercised WKY (EX-WKY, 1 h/day, 5 days/week treadmill exercise training), sedentary SHR (SED-SHR), and exercised SHR (EX-SHR). EX-SHR showed blood pressure reduction of 26% in comparison to SED-SHR after 1 month of exercise (P<0.05). At the 20th week. BP level was not different between EX-SHRs and WKYs. Circumferential wall tension (CWT) was higher by 77% in SED-SHRs than in SED-WKYs (P<0.001). Exercise training reduced CWT by 30% in EX- vs. SED-SHR (P<0.001). In SED-SHRs, endothelial cells showed large and numerous cytoplasmatic vacuoles, fragmented inner elastic lamina and scarce elastin and fibrillin, while exercise training ameliorated it in EX-SHR group. The highest eNOS immunodensity was observed in EX-SHR, which was 50% higher than EX-WKY (P<0.01) and 120% higher than SED-SHR (P<0.0001). In conclusion, present findings indicate beneficial effects of exercise training in hypertensive rats since it increased elastin, fibrillin and eNOS content in the aortic wall. (C) 2010 Elsevier Inc. All rights reserved.
C1 [Mandarim-de-Lacerda, Carlos Alberto] Univ Estado Rio de Janeiro, Ctr Biomed, Inst Biol, Lab Morphometry & Cardiovasc Morphol, BR-20551030 Rio De Janeiro, Brazil.
   [Moraes-Teixeira, Jessica de Andrade; Felix, Alyne; de Carvalho, Jorge Jose] Univ Estado Rio de Janeiro, Lab Cellular Ultrastruct & Tissue Biol, Biomed Ctr, Inst Biol, BR-20551030 Rio De Janeiro, Brazil.
   [Moura, Anibal Sanchez] Univ Estado Rio de Janeiro, Lab Nutr & Dev Physiol, Biomed Ctr, Inst Biol, BR-20551030 Rio De Janeiro, Brazil.
C3 Universidade do Estado do Rio de Janeiro; Universidade do Estado do Rio
   de Janeiro; Universidade do Estado do Rio de Janeiro
RP Mandarim-de-Lacerda, CA (corresponding author), Univ Estado Rio de Janeiro, Ctr Biomed, Inst Biol, Lab Morphometry & Cardiovasc Morphol, Av 28 Setembro,87 Fds, BR-20551030 Rio De Janeiro, Brazil.
EM mandarim@uerj.br
RI Mandarim-de-Lacerda, Carlos/F-7125-2012; Fernandes-Santos,
   Caroline/M-1794-2019; Mandarim-de-Lacerda, Carlos/P-2360-2019
OI Fernandes-Santos, Caroline/0000-0002-2420-3836; Mandarim-de-Lacerda,
   Carlos/0000-0003-4134-7978
FU CNPq; CNPq, National Council for Science and Technology; FAPERJ, Rio de
   Janeiro Foundation
FX This work was supported by the Brazilian agencies: CNPq, National
   Council for Science and Technology and FAPERJ, Rio de Janeiro Foundation
   for Scientific Research.
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NR 40
TC 34
Z9 37
U1 0
U2 9
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0014-4800
EI 1096-0945
J9 EXP MOL PATHOL
JI Exp. Mol. Pathol.
PD DEC
PY 2010
VL 89
IS 3
BP 351
EP 357
DI 10.1016/j.yexmp.2010.08.004
PG 7
WC Pathology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pathology
GA 686FX
UT WOS:000284683300021
PM 20800592
DA 2025-06-11
ER

PT J
AU Guo, W
   Wong, S
   Pudney, J
   Jasuja, R
   Hua, N
   Jiang, L
   Miller, A
   Hruz, PW
   Hamilton, JA
   Bhasin, S
AF Guo, Wen
   Wong, Siu
   Pudney, Jeffrey
   Jasuja, Ravi
   Hua, Ning
   Jiang, Lan
   Miller, Andrew
   Hruz, Paul W.
   Hamilton, James A.
   Bhasin, Shalender
TI Acipimox, an Inhibitor of Lipolysis, Attenuates Atherogenesis in
   LDLR-Null Mice Treated With HIV Protease Inhibitor Ritonavir
SO ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
LA English
DT Article
DE antiretroviral protease inhibitor; adipose tissue; insulin resistance;
   dyslipidemia; acipimox
ID LOW-DENSITY-LIPOPROTEIN; ATHEROSCLEROTIC LESION FORMATION; PERIPHERAL
   INSULIN-RESISTANCE; VIRUS-INFECTED PATIENTS; ANTIRETROVIRAL THERAPY;
   OXIDATIVE STRESS; METABOLIC SYNDROME; NICOTINIC-ACID; FATTY-ACID;
   IN-VIVO
AB Objectives-The advent of HIV protease inhibitors has greatly extended the life span of AIDS patients. With an aging HIV+ population, the cardiometabolic side effects of these drugs are becoming increasingly important clinical concerns. The purpose of this study was to test the hypothesis that inhibition of adipose lipolysis will retard atherogenic lesion development induced by the antiviral protease inhibitors.
   Methods and Results-LDLR-null mice receiving ritonavir were compared with those receiving ritonavir plus lipolysis inhibitor acipimox or vehicle alone to determine how acipimox would affect ritonavir-induced atherogenesis. Intermittent high-fat high-cholesterol diet was used to facilitate optimal atheromatous lesion development. Drug effects were assessed as changes in aortic lesion score, plasma lipid and lipoprotein profile, body fat mass, and insulin-induced suppression of plasma fatty acid concentrations. Ritonavir increased aortic lesions, in association with decreased body fat mass, impaired antilipolysis action of insulin, and increased proatherogenic plasma lipoproteins. All these adverse effects were attenuated by cotreatment with acipimox.
   Conclusions-Our results provide the first direct evidence that supports the hypothesis that dysregulation of adipose lipolysis is an important contributor to the proatherogenic role of selected HIV protease inhibitors. (Arterioscler Thromb Vasc Biol. 2009;29:2028-2032.)
C1 [Guo, Wen; Wong, Siu; Jasuja, Ravi; Jiang, Lan; Bhasin, Shalender] Boston Univ, Endocrinol Sect, Sch Med, Dept Med, Boston, MA 02118 USA.
   [Pudney, Jeffrey] Boston Univ, Sch Med, Dept Obstet Gynecol & Reprod Biol, Boston, MA 02118 USA.
   [Hua, Ning; Hamilton, James A.] Boston Univ, Sch Med, Dept Biophys, Boston, MA 02118 USA.
   [Miller, Andrew] Harvard Univ, Sch Med, Div Comparat Pathol, Southborough, MA 01772 USA.
   [Hruz, Paul W.] Washington Univ, Sch Med, Dept Pediat, St Louis, MO 63110 USA.
C3 Boston University; Boston University; Boston University; Harvard
   University; Washington University (WUSTL)
RP Guo, W (corresponding author), Boston Univ, Endocrinol Sect, Sch Med, Dept Med, 670 Albany St,2nd Floor, Boston, MA 02118 USA.
EM wguo@bu.edu
RI hamilton, john/JCO-1256-2023; pudney, jeffrey/W-8755-2019; Ning,
   HU/AAG-2475-2021; jiang, lan/T-3965-2019; Hruz, Paul/LDE-7189-2024
OI Hruz, Paul W/0000-0002-1478-3355; Hamilton, James/0000-0002-4747-7071;
   Guo, Wen/0000-0002-4474-2837; Pudney, Jeffrey/0000-0001-8121-8586
FU NIH [RO1DK59261, 1RO1DK49296, R01DK64572, 1R01DK078512-01]
FX This research was supported by NIH grants RO1DK59261, 1RO1DK49296,
   R01DK64572, and 1R01DK078512-01.
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NR 47
TC 9
Z9 10
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1079-5642
EI 1524-4636
J9 ARTERIOSCL THROM VAS
JI Arterioscler. Thromb. Vasc. Biol.
PD DEC
PY 2009
VL 29
IS 12
BP 2028
EP U105
DI 10.1161/ATVBAHA.109.191304
PG 25
WC Hematology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Hematology; Cardiovascular System & Cardiology
GA 521TO
UT WOS:000271947300010
PM 19762785
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Kelem, A
   Adane, T
   Shiferaw, E
AF Kelem, Amanuel
   Adane, Tiruneh
   Shiferaw, Elias
TI Insulin Resistance-Induced Platelet Hyperactivity and a Potential
   Biomarker Role of Platelet Parameters: A Narrative Review
SO DIABETES METABOLIC SYNDROME AND OBESITY
LA English
DT Review
DE insulin resistance; platelet hyperactivity; platelet parameter
ID METABOLIC SYNDROME; OXIDATIVE STRESS; CENTRAL OBESITY;
   CYCLIC-NUCLEOTIDES; DISTRIBUTION WIDTH; DIABETES-MELLITUS; NITRIC-OXIDE;
   VOLUME; ACTIVATION; INHIBITION
AB Background: Insulin has an inhibitory effect on platelets; however, this is compromised in circumstances of Insulin Resistance (IR), leading to platelet hyperactivity. Platelet parameters such as mean platelet volume, platelet count, and platelet distribution width are simple and accessible potential biomarkers for the early diagnosis and prognosis of IR. Therefore, the aim of this review is to provide insight on the current status of knowledge regarding IR-induced platelet hyperactivation and the potential biomarker role of platelet parameters. Methods: This narrative review included articles published in the English language. Searches were carried out at the electronic databases PubMed and Google Scholar. The search strategy was done by combining key words and related database-specific subject terms (Mesh terms) with the appropriate Boolean operators. Conclusion: Increasing insulin sensitivity in insulin resistant patients would possibly cause substantial reduction in platelet activation, which in turn reduce complications related with platelet hyperactivation. The standard methods to measure IR are not frequently employed in clinical practice due to their expensiveness and complexity. Thus, early detection of IR using a simple and more widely available biomarkers such as mean platelet volume, platelet count and platelet distribution width would be beneficial. Particularly in developing countries where resource scarcity is a major constraint of the health sector, utilizing such easy and affordable biomarkers may have a crucial role.
C1 [Kelem, Amanuel] Debre Berhan Univ, Dept Med Lab Sci, Asrat Woldeyes Hlth Sci Campus, Debre Berhan, Ethiopia.
   [Adane, Tiruneh; Shiferaw, Elias] Univ Gondar, Coll Med & Hlth Sci, Sch Biomed & Lab Sci, Dept Hematol & Immunohematol, Gondar, Ethiopia.
C3 University of Gondar
RP Kelem, A (corresponding author), Debre Berhan Univ, Dept Med Lab Sci, Asrat Woldeyes Hlth Sci Campus, Debre Berhan, Ethiopia.
EM amanuelkelem@gmail.com
RI ; Adane, Tiruneh/AAV-2999-2021
OI Kelem, Amanuel/0000-0002-4021-0171; Adane, Tiruneh/0000-0001-6597-5755;
   Shiferaw, Elias/0000-0001-8374-3560
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NR 68
TC 11
Z9 12
U1 0
U2 0
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-7007
J9 DIABET METAB SYND OB
JI Diabetes Metab. Syndr. Obes.
PY 2023
VL 16
BP 2843
EP 2853
DI 10.2147/DMSO.S425469
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA S6ZR2
UT WOS:001072634000001
PM 37744701
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Pfisterer, J
   Rausch, C
   Wohlfarth, D
   Bachert, P
   Jekauc, D
   Wunsch, K
AF Pfisterer, Julia
   Rausch, Constantin
   Wohlfarth, Doreen
   Bachert, Philip
   Jekauc, Darko
   Wunsch, Kathrin
TI Effectiveness of Physical-Activity-Based Interventions Targeting
   Overweight and Obesity among University Students-A Systematic Review
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Review
DE physical-activity-based interventions; overweight; obesity; BMI; change;
   university students; tertiary education; review
ID BODY-MASS INDEX; METABOLIC SYNDROME; EXERCISE; STRESS; PREVALENCE;
   LEVEL; RISK
AB Overweight and obesity, including their prevalence and consequences, reflect a leading public health problem. Studies have already shown that physical activity leads to a reduction in body weight in children and adults. However, the university setting has rarely been investigated. The aim of this review is, therefore, to examine and summarize the effectiveness of physical-activity-based interventions to reduce obesity and overweight in university students. Three databases (PubMed, Scopus, and Web of Science) were searched for relevant studies published in English between January 2010 and February 2022. Quantitative studies conducting a physical-activity-based intervention with overweight or obese university students and reporting changes in BMI were included. Data were described in a narrative synthesis. Out of 16 included studies, 11 reported a significant reduction in BMI. However, all studies except one were able to demonstrate some BMI improvements, whereas all studies reported significant changes in at least one health-related indicator. Aerobic exercises were able to demonstrate the greatest reductions in BMI. This review is the first systematic presentation on the effectiveness of physical-activity-based interventions in overweight and obese university students. Future work should reconsider BMI as the primary outcome if appropriate within the respective study design (i.e., to measure long-term effects). More interventions are needed to improve strategies.
C1 [Pfisterer, Julia; Rausch, Constantin; Wohlfarth, Doreen; Bachert, Philip; Jekauc, Darko; Wunsch, Kathrin] Karlsruhe Inst Technol, Inst Sports & Sports Sci, D-76131 Karlsruhe, Germany.
C3 Helmholtz Association; Karlsruhe Institute of Technology
RP Wunsch, K (corresponding author), Karlsruhe Inst Technol, Inst Sports & Sports Sci, D-76131 Karlsruhe, Germany.
EM julia.pfisterer@student.kit.edu; constantin.rausch@student.kit.edu;
   doreen.wohlfarth@student.kit.edu; philip.bachert@kit.edu;
   darko.jekauc@kit.edu; kathrin.wunsch@kit.edu
RI Wunsch, Kathrin/AAL-2850-2021
OI Rausch, Constantin/0000-0003-1040-8395; Wohlfarth,
   Doreen/0000-0003-0258-5033; Jekauc, Darko/0000-0002-7640-5149; Bachert,
   Philip/0000-0002-7667-3258; Wunsch, Kathrin/0000-0001-9400-4130;
   Pfisterer, Julia/0000-0002-5139-3989
FU KIT-Publication Fund of the Karlsruhe Institute of Technology
FX We acknowledge support from the KIT-Publication Fund of the Karlsruhe
   Institute of Technology.
CR American College Health Association (ACHA), 2021, NAT COLL HLTH ASS 3
   [Anonymous], Guidance on the conduct of narrative synthesis in systematic reviews
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NR 63
TC 4
Z9 4
U1 3
U2 28
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD AUG
PY 2022
VL 19
IS 15
AR 9427
DI 10.3390/ijerph19159427
PG 23
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA 3R4CQ
UT WOS:000838863400001
PM 35954789
OA gold, Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Delarocque, J
   Frers, F
   Huber, K
   Jung, K
   Feige, K
   Warnken, T
AF Delarocque, Julien
   Frers, Florian
   Huber, Korinna
   Jung, Klaus
   Feige, Karsten
   Warnken, Tobias
TI Metabolic impact of weight variations in Icelandic horses
SO PEERJ
LA English
DT Article
DE Equine metabolic syndrome; Insulin dysregulation; Oral glucose test;
   Obesity; Metabolomics; Pathway analysis
ID AMINO-ACID-METABOLISM; INSULIN SENSITIVITY; LIPID CONCENTRATIONS;
   ARGINASE ACTIVITY; OXIDATIVE STRESS; PLASMA-HORMONE; L-ARGININE;
   ADIPOSITY; OBESITY; HYPERINSULINEMIA
AB Background. Insulin dysregulation (ID) is an equine endocrine disorder, which is often accompanied by obesity and various metabolic perturbations. The relationship between weight variations and fluctuations of the insulin response to oral glucose tests (OGT) as well as the metabolic impact of ID have been described previously. The present study seeks to characterize the concomitant metabolic impact of variations in the insulin response and bodyweight during repeated OGTs using a metabolomics approach.
   Methods. Nineteen Icelandic horses were subjected to five OGTs over one year and their bodyweight, insulin and metabolic response were monitored. Analysis of metabolite concentrations depending on time (during the OGT), relative bodyweight (rWeight; defined as the bodyweight at one OGT divided by the mean bodyweight across all OGTs) and relative insulin response (rAUC(ins); defined accordingly from the area under the insulin curve during OGT) was performed using linear models. Additionally, the pathways significantly associated with time, rWeight and rAUC(ins) were identified by rotation set testing.
   Results. The results suggested that weight gain and worsening of ID activate distinct metabolic pathways. The metabolic profile associated with weight gain indicated an increased activation of arginase, while the pathways associated with time and rAUC(ins) were consistent with the expected effect of glucose and insulin, respectively. Overall, more metabolites were significantly associated with rWeight than with rAUC(ins).
C1 [Delarocque, Julien; Frers, Florian; Feige, Karsten; Warnken, Tobias] Univ Vet Med Hannover, Clin Horses, Hannover, Germany.
   [Huber, Korinna] Univ Hohenheim, Fac Agr Sci, Inst Anim Sci, Stuttgart, Germany.
   [Jung, Klaus] Tierarztliche Hsch Hannover, Inst Anim Breeding & Genet, Hannover, Germany.
C3 University of Veterinary Medicine Hannover; University Hohenheim;
   University of Veterinary Medicine Hannover
RP Delarocque, J (corresponding author), Univ Vet Med Hannover, Clin Horses, Hannover, Germany.
EM julien.delarocque@tiho-hannover.de
RI Delarocque, Julien/HHM-8412-2022
OI Delarocque, Julien/0000-0002-4598-3499; Warnken,
   Tobias/0000-0002-0741-4674
FU Deutsche Forschungsgemeinschaft; University of Veterinary Medicine
   Hannover
FX This publication was supported by Deutsche Forschungsgemeinschaft and
   University of Veterinary Medicine Hannover, Foundation within the
   funding programme Open Access Publishing. The funders had no role in
   study design, data collection and analysis, decision to publish, or
   preparation of the manuscript.
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NR 52
TC 5
Z9 5
U1 0
U2 5
PU PEERJ INC
PI LONDON
PA 341-345 OLD ST, THIRD FLR, LONDON, EC1V 9LL, ENGLAND
SN 2167-8359
J9 PEERJ
JI PeerJ
PD JAN 28
PY 2021
VL 9
AR e10764
DI 10.7717/peerj.10764
PG 16
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA PZ2TX
UT WOS:000612593700007
PM 33575132
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU He, A
   Zuo, DY
   Liang, XX
   Guo, YZ
   Suxin, L
   Xia, Y
AF He, An
   Zuo, Deyu
   Liang, Xiaoxue
   Guo, Yongzheng
   Suxin, Luo
   Xia, Yong
TI Hypoglycemia increases endothelial-dependent vasodilation through
   suppressing phosphorylation at Threonine 495/497 site of endothelial
   nitric oxide synthase
SO MICROVASCULAR RESEARCH
LA English
DT Article
DE Hypoglycemia; eNOS phosphorylation; Endothelium-dependent vasodilation
ID ACTIVATED PROTEIN-KINASE; INSULIN-INDUCED HYPOGLYCEMIA; ARTERIAL-BLOOD
   FLOW; OXIDATIVE STRESS; METABOLIC SYNDROME; ENERGY SENSOR; C-ZETA;
   INFLAMMATION; INHIBITION; INFARCTION
AB Objective: Phosphorylation plays an essential role in the regulation of endothelial nitric oxide synthase (eNOS) activity. However, the phosphorylation of eNOS under hypoglycemia and whether hypoglycemia changes eNOS activity is unknown. This paper aims to clarify the regulation of eNOS phosphorylation and its activity change under hypoglycemia.
   Methods: Bovine aortic endothelial cells (BAECs) and Sprague-Dawley rats were treated with hypoglycemia, and the phosphorylation of eNOS was subjected to western blot. Blood nitric oxide (NO) concentration was determined by NO kit and endothelial-dependent vasodilation was detected by multi-wire myograph.
   Results: In both BAECs and rats' thoracic aorta, hypoglycemia induced eNOS phosphorylation decrease specifically on Threonine (Thr) 497. Inhibition of ubiquitination of protein kinase C alpha subunit (PKC alpha) reverses the decrease of eNOS phosphorylation in hypoglycemia. Ubiquitinated PKC alpha can be reversed by AMPK knockdown. In rats, insulin induced hypoglycemia increased the concentration of NO in arterial blood, and progressively enhanced the endothelium-dependent vasodilation of the thoracic and mesenteric aorta.
   Conclusions: In vitro, the activation of AMPK may lead to the expression of PKC alpha by regulating ubiquitination, resulting in a decrease in the level of P-eNOS Thr497 phosphorylation under hypoglycemia. In vivo, insulininduced hypoglycemia produces a beneficial cardiovascular effect on rats.
C1 [He, An; Zuo, Deyu; Liang, Xiaoxue; Guo, Yongzheng; Suxin, Luo; Xia, Yong] Chongqing Med Univ, Affiliated Hosp 1, Div Cardiol, Chongqing 400016, Peoples R China.
   [Xia, Yong] Chongqing Med Univ, Inst Life Sci, Chongqing 400016, Peoples R China.
C3 Chongqing Medical University; Chongqing Medical University
RP Suxin, L; Xia, Y (corresponding author), Chongqing Med Univ, Affiliated Hosp 1, Div Cardiol, Chongqing 400016, Peoples R China.
EM luosuxin0204@163.com; cqmu_cardiology@163.com
RI Zuo, Deyu/AGG-3892-2022; He, An/AAM-7254-2020
FU National Basic Research program of China [2014CB542402]; National
   Natural Science Foundation of China [81270210]
FX This work was supported by grants from the National Basic Research
   program of China (No. 2014CB542402) and the National Natural Science
   Foundation of China (No. 81270210).
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NR 46
TC 8
Z9 9
U1 0
U2 9
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0026-2862
EI 1095-9319
J9 MICROVASC RES
JI Microvasc. Res.
PD JAN
PY 2021
VL 133
AR 104075
DI 10.1016/j.mvr.2020.104075
PG 9
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA QA1HD
UT WOS:000613199900006
PM 32950484
DA 2025-06-11
ER

PT J
AU Ma, YJ
   Cao, HM
   Li, ZX
   Fang, JZ
   Wei, XM
   Cheng, P
   Jiao, R
   Liu, XR
   Li, Y
   Xing, Y
   Tang, JL
   Jin, L
   Li, TM
AF Ma, Yanjie
   Cao, Huimin
   Li, Zhixin
   Fang, Jinzhi
   Wei, Xiaomin
   Cheng, Peng
   Jiao, Rui
   Liu, Xiaoran
   Li, Ya
   Xing, Yun
   Tang, Jiali
   Jin, Liang
   Li, Taiming
TI A Novel Multi-Epitope Vaccine Based on Urate Transporter 1 Alleviates
   Streptozotocin-Induced Diabetes by Producing Anti-URAT1 Antibody and an
   Immunomodulatory Effect in C57BL/6J Mice
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE diabetes; hyperuricemia; urate transporter 1; uric acid; antibody
ID URIC-ACID; METABOLIC SYNDROME; CARDIOVASCULAR-DISEASE;
   INSULIN-RESISTANCE; HYPERURICEMIA; GOUT; FEBUXOSTAT; GLUCOSE; PROTEIN;
   RISK
AB Hyperuricemia (HUA) is related to diabetes. Uric acid-induced inflammation and oxidative stress are risk factors for diabetes and its complications. Human urate transporter 1 (URAT1) regulates the renal tubular reabsorption of uric acid. IA-2(5)-P2-1, a potent immunogenic carrier designed by our laboratory, can induce high-titer specific antibodies when it carries a B cell epitope, such as B cell epitopes of DPP4 (Dipeptidyl peptidase-4), xanthine oxidase. In this report, we describe a novel multi-epitope vaccine composing a peptide of URAT1, an anti-diabetic B epitope of insulinoma antigen-2(IA-2) and a Th2 epitope (P2:IPALDSLTPANED) of P277 peptide in human heat shock protein 60 (HSP60). Immunization with the multi-epitope vaccine in streptozotocin-induced diabetes C57BL/6J mice successfully induced specific anti-URAT1 antibody, which inhibited URAT1 action and uric acid reabsorption, and increased pancreatic insulin level with a lower insulitis incidence. Vaccination with U-IA-2(5)-P2-1 (UIP-1) significantly reduced blood glucose and uric acid level, increased Th2 cytokines interleukin (IL)-10 and IL-4, and regulated immune reactions through a balanced Th1/Th2 ratio. These results demonstrate that the URAT1-based multi-epitope peptide vaccine may be a suitable therapeutic approach for diabetes and its complications.
C1 [Ma, Yanjie; Cao, Huimin; Li, Zhixin; Fang, Jinzhi; Wei, Xiaomin; Cheng, Peng; Jiao, Rui; Liu, Xiaoran; Li, Ya; Xing, Yun; Tang, Jiali; Jin, Liang; Li, Taiming] China Pharmaceut Univ, Sch Life Sci & Technol, Nanjing 210009, Jiangsu, Peoples R China.
C3 China Pharmaceutical University
RP Li, TM (corresponding author), China Pharmaceut Univ, Sch Life Sci & Technol, Nanjing 210009, Jiangsu, Peoples R China.
EM 14211030526@stu.cpu.edu.cn; 1621030544@stu.cpu.edu.cn;
   14211030601@stu.cpu.edu.cn; 2020140639@stu.cpu.edu.cn;
   13211030585@stu.cpu.edu.cn; 15211030512@stu.cpu.edu.cn;
   15211030561@stu.cpu.edu.cn; 14211030603@stu.cpu.edu.cn;
   1621030486@stu.cpu.edu.cn; xingyun_503@163.com; 13645195250@163.com;
   liangjin1975@cpu.edu.cn; taimingli@163.com
RI Cheng, Peng/R-6211-2016; Liu, Xiaoran/AAL-3659-2020
FU National Natural Science Foundation [30672464]; College Students
   Innovation Project for the R&D of Novel Drugs [J1310032]; Priority
   Academic Program Development of Jiangsu Higher Education Institutions
   (PAPD); Research Innovation Program for Graduates of Jiangsu Province
   [KYZZ16_0422, KYZZ_0191, KYCX17_0665]; Top-notch Academic Programs
   Project of Jiangsu Higher Education Institutions [PPZY2015A057];
   National Found for Fostering Talents of Basic Science (NFFTBS); Qing Lan
   project of Jiangsu Province
FX This work was supported by the National Natural Science Foundation (No.
   30672464); the College Students Innovation Project for the R&D of Novel
   Drugs (No. J1310032); a project funded by the Priority Academic Program
   Development of Jiangsu Higher Education Institutions (PAPD), the
   Research Innovation Program for Graduates of Jiangsu Province (No.
   KYZZ16_0422, No. KYZZ_0191, No. KYCX17_0665); the Top-notch Academic
   Programs Project of Jiangsu Higher Education Institutions (No.
   PPZY2015A057); the National Found for Fostering Talents of Basic Science
   (NFFTBS); and Qing Lan project of Jiangsu Province.
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NR 55
TC 6
Z9 6
U1 1
U2 17
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD OCT
PY 2017
VL 18
IS 10
AR 2137
DI 10.3390/ijms18102137
PG 17
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA FM0QL
UT WOS:000414671800121
PM 29035321
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Salaritabar, A
   Darvishi, B
   Hadjiakhoondi, F
   Manayi, A
   Sureda, A
   Nabavi, SF
   Fitzpatrick, LR
   Nabavi, SM
   Bishayee, A
AF Salaritabar, Ali
   Darvishi, Behrad
   Hadjiakhoondi, Farzaneh
   Manayi, Azadeh
   Sureda, Antoni
   Nabavi, Seyed Fazel
   Fitzpatrick, Leo R.
   Nabavi, Seyed Mohammad
   Bishayee, Anupam
TI Therapeutic potential of flavonoids in inflammatory bowel disease: A
   comprehensive review
SO WORLD JOURNAL OF GASTROENTEROLOGY
LA English
DT Review
DE Antioxidant; Inflammation; Gastrointestinal tract; Flavonoids;
   Polyphenols
ID DEXTRAN SULFATE SODIUM; INTESTINAL ANTIINFLAMMATORY ACTIVITY;
   AMELIORATES EXPERIMENTAL COLITIS; SIGNAL-TRANSDUCTION PATHWAYS; DIETARY
   PHENOLIC-COMPOUNDS; INDUCED ULCERATIVE-COLITIS; ACID-INDUCED COLITIS;
   ANTIOXIDANT ACTIVITY; OXIDATIVE STRESS; IN-VITRO
AB The inflammatory process plays a central role in the development and progression of numerous pathological situations, such as inflammatory bowel disease (IBD), autoimmune and neurodegenerative diseases, metabolic syndrome, and cardiovascular disorders. IBDs involve inflammation of the gastrointestinal area and mainly comprise Crohn's disease (CD) and ulcerative colitis (UC). Both pathological situations usually involve recurring or bloody diarrhea, pain, fatigue and weight loss. There is at present no pharmacological cure for CD or UC. However, surgery may be curative for UC patients. The prescribed treatment aims to ameliorate the symptoms and prevent and/or delay new painful episodes. Flavonoid compounds are a large family of hydroxylated polyphenolic molecules abundant in plants, including vegetables and fruits which are the major dietary sources of these compounds for humans, together with wine and tea. Flavonoids are becoming very popular because they have many health-promoting and disease-preventive effects. Most interest has been directed towards the antioxidant activity of flavonoids, evidencing a remarkable free-radical scavenging capacity. However, accumulating evidence suggests that flavonoids have many other biological properties, including anti-inflammatory, antiviral, anticancer, and neuroprotective activities through different mechanisms of action. The present review analyzes the available data about the different types of flavonoids and their potential effectiveness as adjuvant therapy of IBDs.
C1 [Salaritabar, Ali; Darvishi, Behrad] ACECR, Motamed Canc Inst, Dept Integrat Oncol, Breast Canc Res Ctr, Tehran 1517964311, Iran.
   [Salaritabar, Ali; Darvishi, Behrad] ACECR, Motamed Canc Inst, Dept Recombinant Prot, Breast Canc Res Ctr, Tehran 1517964311, Iran.
   [Hadjiakhoondi, Farzaneh; Manayi, Azadeh] Univ Tehran Med Sci, Med Plants Res Ctr, Fac Pharm, Tehran 1417614411, Iran.
   [Sureda, Antoni] Univ Balearic Isl, Res Grp Community Nutr & Oxidat Stress, E-07122 Palma De Mallorca, Balearic Island, Spain.
   [Sureda, Antoni] Univ Balearic Isl, CIBEROBN Physiopathol Obes & Nutr, E-07122 Palma De Mallorca, Balearic Island, Spain.
   [Nabavi, Seyed Fazel; Nabavi, Seyed Mohammad] Baqiyatallah Univ Med Sci, Appl Biotechnol Res Ctr, Tehran 1435916471, Iran.
   [Fitzpatrick, Leo R.] Calif Northstate Univ, Coll Pharm, Dept Pharmaceut & Biomed Sci, Elk Grove, CA 95757 USA.
   [Bishayee, Anupam] Larkin Univ, Dept Pharmaceut Sci, Coll Pharm, Miami, FL 33169 USA.
C3 Academic Center for Education, Culture & Research (ACECR); Academic
   Center for Education, Culture & Research (ACECR); Tehran University of
   Medical Sciences; Universitat de les Illes Balears; CIBER - Centro de
   Investigacion Biomedica en Red; CIBEROBN; Universitat de les Illes
   Balears; Baqiyatallah University of Medical Sciences (BMSU)
RP Bishayee, A (corresponding author), Larkin Univ, Dept Pharmaceut Sci, Coll Pharm, Miami, FL 33169 USA.
EM abishayee@ularkin.org
RI Nabavi, Seyed Mohammad/G-5335-2010; nabavi, seyed fazel/A-2223-2010;
   Manayi, Azadeh/AAO-4121-2021; Bishayee, Anupam/G-4290-2012; Darvishi,
   Behrad/L-7931-2018; Sureda, Antoni/N-9588-2019
OI , Antoni/0000-0001-8656-6838; Bishayee, Anupam/0000-0001-9159-960X
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NR 172
TC 143
Z9 152
U1 2
U2 75
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 7041 Koll Center Parkway, Suite 160, PLEASANTON, CA, UNITED STATES
SN 1007-9327
EI 2219-2840
J9 WORLD J GASTROENTERO
JI World J. Gastroenterol.
PD JUL 28
PY 2017
VL 23
IS 28
BP 5097
EP 5114
DI 10.3748/wjg.v23.i28.5097
PG 18
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA FD5GT
UT WOS:000407559600006
PM 28811706
OA Green Submitted, Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Xu, JL
   Donepudi, AC
   More, VR
   Kulkarni, SR
   Li, LY
   Guo, LR
   Yan, BF
   Chatterjee, T
   Weintraub, N
   Slitt, AL
AF Xu, Jialin
   Donepudi, Ajay C.
   More, Vijay R.
   Kulkarni, Supriya R.
   Li, Liya
   Guo, Liangran
   Yan, Bingfang
   Chatterjee, Tapan
   Weintraub, Neal
   Slitt, Angela L.
TI Deficiency in Nrf2 Transcription Factor Decreases Adipose Tissue Mass
   and Hepatic Lipid Accumulation in Leptin-Deficient Mice
SO OBESITY
LA English
DT Article
ID HIGH-FAT DIET; FACTOR E2-RELATED FACTOR-2; INSULIN-RESISTANCE; INDUCED
   OBESITY; ADIPOCYTE DIFFERENTIATION; IMPAIRED ADIPOGENESIS; METABOLIC
   SYNDROME; DIABETES-MELLITUS; OXIDATIVE STRESS; GENE-EXPRESSION
AB ObjectiveTo evaluate whether Nrf2 deficiency impacts insulin resistance and lipid accumulation in liver and white adipose tissue.
   MethodsLep(ob/ob) mice (OB) with targeted Nrf2 deletion (OB-Nrf2KO) were generated. Pathogenesis of obesity and type 2 diabetes was measured in C57BL/6J, Nrf2KO, OB, and OB-Nrf2KO mice. Hepatic lipid content, lipid clearance, and very low-density lipoprotein (VLDL) secretion were determined between OB and OB-Nrf2KO mice.
   ResultsOB-Nrf2KO mice exhibited decreased white adipose tissue mass and decreased adipogenic and lipogenic gene expression compared with OB mice. Nrf2 deficiency prolonged hyperglycemia in response to glucose challenge, which was paralleled by reduced insulin-stimulated Akt phosphorylation. In OB mice, Nrf2 deficiency decreased hepatic lipid accumulation, decreased peroxisome proliferator-activated receptor expression and nicotinamide adenine dinucleotide phosphate (NADPH) content, and enhanced VLDL secretion. However, this observation was opposite in lean mice. Additionally, OB-Nrf2KO mice exhibited increased plasma triglyceride content, decreased HDL-cholesterol content, and enhanced apolipoprotein B expression, suggesting Nrf2 deficiency caused dyslipidemia in these mice.
   ConclusionsNrf2 deficiency in Lep(ob/ob) mice reduced white adipose tissue mass and prevented hepatic lipid accumulation but induced insulin resistance and dyslipidemia. This study indicates a dual role of Nrf2 during metabolic dysregulationincreasing lipid accumulation in liver and white adipose tissue but preventing lipid accumulation in obese mice.
C1 [Xu, Jialin; Donepudi, Ajay C.; More, Vijay R.; Kulkarni, Supriya R.; Li, Liya; Guo, Liangran; Yan, Bingfang; Slitt, Angela L.] Univ Rhode Isl, Dept Biomed & Pharmaceut Sci, Kingston, RI USA.
   [Xu, Jialin] Northeastern Univ, Inst Biochem & Mol Biol, Coll Life & Hlth Sci, Shenyang, Peoples R China.
   [Li, Liya] Northeastern Univ, Inst Microbial Pharmaceut, Coll Life & Hlth Sci, Shenyang, Peoples R China.
   [Chatterjee, Tapan; Weintraub, Neal] Univ Cincinnati, Coll Med, Cincinnati, OH USA.
C3 University of Rhode Island; Northeastern University - China;
   Northeastern University - China; University System of Ohio; University
   of Cincinnati
RP Slitt, AL (corresponding author), Univ Rhode Isl, Dept Biomed & Pharmaceut Sci, Kingston, RI 02881 USA.
EM aslitt@uri.edu
RI ZHU, XIAOYU/HJY-7240-2023; Chatterjee, Rima/J-8066-2017
OI Weintraub, Neal/0000-0002-5138-3705; Kulkarni,
   Supriya/0000-0002-3146-0582
FU National Institutes of Health [5R01ES016042, 5K22ES013782]; Rhode Island
   IDeA Network of Biomedical Research Excellence Award from the National
   Center for Research Resources [P20RR016457-10]; National Science
   Foundation of China [81341102]; Fundamental Research Funds of
   Northeastern University [N130220001]
FX This work was supported by National Institutes of Health grants
   (5R01ES016042 and 5K22ES013782) awarded to AS and by Rhode Island IDeA
   Network of Biomedical Research Excellence Award (P20RR016457-10) from
   the National Center for Research Resources. JX was also supported by the
   National Science Foundation of China (81341102), and Fundamental
   Research Funds of Northeastern University (N130220001).
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NR 36
TC 28
Z9 30
U1 0
U2 20
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1930-7381
EI 1930-739X
J9 OBESITY
JI Obesity
PD FEB
PY 2015
VL 23
IS 2
BP 335
EP 344
DI 10.1002/oby.20929
PG 10
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA CA6QN
UT WOS:000349040400015
PM 25451536
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Devaraj, S
   Torok, N
   Dasu, MR
   Samols, D
   Jialal, I
AF Devaraj, Sridevi
   Torok, Natalie
   Dasu, Mohan R.
   Samols, David
   Jialal, Ishwarlal
TI Adiponectin decreases C-reactive protein synthesis and secretion from
   endothelial cells - Evidence for an adipose tissue-vascular loop
   (Publication with Expression of Concern. See vol. 40, 2020)
SO ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
LA English
DT Article; Publication with Expression of Concern
DE CRP; adiponectin; endothelium; adipose
ID NITRIC-OXIDE PRODUCTION; OXIDATIVE STRESS; GENE-EXPRESSION; GLOBULAR
   DOMAIN; GLUCOSE; INFLAMMATION; KINASE; INHIBITION; MACROPHAGES;
   SENSITIVITY
AB Background and Objective-Inflammation is pivotal in atherosclerosis. C-reactive protein (CRP), in addition to being a cardiovascular risk marker, may also be proatherogenic. We have previously shown that in addition to the liver, human aortic endothelial cells (HAECs) synthesize and secrete CRP. Whereas CRP levels are increased in obesity, metabolic syndrome, and diabetes, levels of adiponectin are reduced in these conditions. We tested the hypothesis that adiponectin reduces CRP synthesis and secretion in HAECs under normoglycemic (5.5 mmol/L glucose) and hyperglycemic conditions (15 mmol/L glucose).
   Methods and Results-Adiponectin dose-dependently reduced CRP mRNA and protein from HAECs. Adiponectin treatment of HAECs significantly decreased I kappa B phosphorylation and NF kappa B binding activity. There was no effect of adiponectin on STAT or C/EBP transcriptional activity. Adiponectin also activated AMP kinase resulting in decreased NF kappa B activity and decreased CRP mRNA and protein. These effects of adiponectin were mimicked by AICAR, an activator of AMPK, and reversed by inhibition of AMPK. Thus, adiponectin reduces CRP synthesis and secretion from HAECs under hyperglycemia via upregulation of AMP kinase and downregulation of NF kappa B. Similar findings were observed in rat primary hepatocytes.
   Conclusions-Thus, in obesity and diabetes, the hypoadiponectinemia could exacerbate the proinflammatory state by inducing CRP production.
C1 [Devaraj, Sridevi; Dasu, Mohan R.; Jialal, Ishwarlal] UC Davis Med Ctr, Lab Atherosclerosis & Metab Res, Sacramento, CA 95817 USA.
   [Torok, Natalie] UC Davis Med Ctr, Dept Internal Med, Sacramento, CA 95817 USA.
   [Samols, David] Case Western Reserve Univ, Dept Biochem, Cleveland, OH 44106 USA.
C3 University of California System; University of California Davis;
   University of California System; University of California Davis;
   University System of Ohio; Case Western Reserve University
RP Jialal, I (corresponding author), UC Davis Med Ctr, Lab Atherosclerosis & Metab Res, Res Bldg 1,Rm 3000,4635 2nd Ave, Sacramento, CA 95817 USA.
EM ijialal@ucdavis.edu
RI Jialal, Ishwarlal/AAG-6218-2019
FU NCCIH NIH HHS [K24AT00596, K24 AT000596] Funding Source: Medline; NHLBI
   NIH HHS [R01 HL074360, HL74360] Funding Source: Medline
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NR 43
TC 100
Z9 122
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1079-5642
EI 1524-4636
J9 ARTERIOSCL THROM VAS
JI Arterioscler. Thromb. Vasc. Biol.
PD JUL
PY 2008
VL 28
IS 7
BP 1368
EP 1374
DI 10.1161/ATVBAHA.108.163303
PG 7
WC Hematology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Hematology; Cardiovascular System & Cardiology
GA 315OX
UT WOS:000256890400029
PM 18451326
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Rao, ZH
   Tang, YL
   Zhu, JM
   Lu, ZZ
   Chen, ZC
   Wang, JJ
   Bao, YX
   Mukondiwa, AV
   Wang, C
   Wang, XJ
   Luo, YD
   Li, XK
AF Rao, Zhiheng
   Tang, Yuli
   Zhu, Jiamei
   Lu, Zhenzhen
   Chen, Zhichao
   Wang, Jiaojiao
   Bao, Yuxuan
   Mukondiwa, Alan Vengai
   Wang, Cong
   Wang, Xiaojie
   Luo, Yongde
   Li, Xiaokun
TI Enhanced FGF21 Delivery via Neutrophil-Membrane-Coated Nanoparticles
   Improves Therapeutic Efficacy for Myocardial Ischemia-Reperfusion Injury
SO NANOMATERIALS
LA English
DT Article
DE neutrophil-membrane-coated nanoparticle; fibroblast growth factor 21
   (FGF21); drug delivery; ischemia and reperfusion injury; myocardial
   infarction
ID GROWTH-FACTOR 21; PPAR-ALPHA; PROTECTION; INFARCTION; APOPTOSIS; DEATH
AB Acute myocardial infarction, a leading cause of death globally, is often associated with cardiometabolic disorders such as atherosclerosis and metabolic syndrome. Metabolic treatment of these disorders can improve cardiac outcomes, as exemplified by the GLP-1 agonist semaglutide. Fibroblast growth factor 21 (FGF21), a novel metabolic regulator, plays pivotal roles in lipid mobilization and energy conversion, reducing lipotoxicity, inflammation, mitochondrial health, and subsequent tissue damage in organs such as the liver, pancreas, and heart. Here, we test the therapeutic efficacy of FGF21 in mice with ischemia-reperfusion (I/R) injury, a model of acute myocardial infarction. We employed the strategic method of coating the FGF21-encapsulating liposomal nanoparticles with a neutrophil membrane designed to camouflage FGF21 from macrophage-mediated efferocytotic clearance and promote its targeted accumulation at I/R foci due to the inherent neutrophilic attraction to the inflammatory site. Our findings revealed that the coated FGF21 nanoparticles markedly accumulated within the lesions with a prolonged half-life, in additional to the liver, leading to substantial improvements in cardiac performance by enhancing mitochondrial energetic function and reducing oxidative stress, inflammation, and cell death. Therefore, our research highlights a viable strategy for the enhanced delivery of therapeutical FGF21 analogs to lesions beyond the liver following myocardial infarction.
C1 [Rao, Zhiheng; Tang, Yuli; Zhu, Jiamei; Lu, Zhenzhen; Chen, Zhichao; Wang, Jiaojiao; Bao, Yuxuan; Mukondiwa, Alan Vengai; Wang, Cong; Wang, Xiaojie; Luo, Yongde; Li, Xiaokun] Wenzhou Med Univ, Sch Pharmaceut Sci, Wenzhou 325035, Peoples R China.
   [Luo, Yongde; Li, Xiaokun] Oujiang Lab, Wenzhou 325000, Peoples R China.
   [Luo, Yongde; Li, Xiaokun] Wenzhou Med Univ, Affiliated Hosp 1, Wenzhou 325000, Peoples R China.
C3 Wenzhou Medical University; Oujiang Laboratory; Wenzhou Medical
   University
RP Luo, YD; Li, XK (corresponding author), Wenzhou Med Univ, Sch Pharmaceut Sci, Wenzhou 325035, Peoples R China.; Luo, YD; Li, XK (corresponding author), Oujiang Lab, Wenzhou 325000, Peoples R China.; Luo, YD; Li, XK (corresponding author), Wenzhou Med Univ, Affiliated Hosp 1, Wenzhou 325000, Peoples R China.
EM logoswzmc@gmail.com; yuriitang@163.com; zjm15727965307@163.com;
   lzzlzz0213@163.com; czc3622@163.com; erjiao626@163.com;
   baoyuxuan233@163.com; alanvengaimk@gmail.com; wangcong0814@163.com;
   susanwang1214@wmu.edu.cn; yongdeluo08@wmu.edu.cn; xiaokunli@wmu.edu.cn
RI 朱, 朱/JNS-1507-2023; Bao, Yuxuan/HTR-6132-2023
FU Wenzhou Medical University and the First Affiliated Hospital; Wenzhou
   Medical University [15185]; First Affiliated Hospital [U22A20385];
   National Natural Science Foundation of China
FX This research was funded by Startup funds from Wenzhou Medical
   University and the First Affiliated Hospital (15185 to Y.L.), as well as
   the National Natural Science Foundation of China (U22A20385 to X.L.).
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NR 49
TC 0
Z9 0
U1 4
U2 4
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2079-4991
J9 NANOMATERIALS-BASEL
JI Nanomaterials
PD MAR
PY 2025
VL 15
IS 5
AR 346
DI 10.3390/nano15050346
PG 18
WC Chemistry, Multidisciplinary; Nanoscience & Nanotechnology; Materials
   Science, Multidisciplinary; Physics, Applied
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Science & Technology - Other Topics; Materials Science;
   Physics
GA Z9Z6W
UT WOS:001442404000001
PM 40072149
OA gold
DA 2025-06-11
ER

PT J
AU Zheng, W
   Liu, WY
   Lou, WH
   Targher, G
   Byrne, CD
   Hegyi, P
   Eslam, M
   George, J
   Zheng, MH
AF Zheng, Wen
   Liu, Wen-Yue
   Lou, Wenhui
   Targher, Giovanni
   Byrne, Christopher D.
   Hegyi, Peter
   Eslam, Mohammed
   George, Jacob
   Zheng, Ming-Hua
TI From NAFPD to MAFPD: a literature review of implications of a
   nomenclature change
SO HEPATOBILIARY SURGERY AND NUTRITION
LA English
DT Review; Early Access
DE Metabolic dysfunction-associated fatty liver disease (MAFLD);
   nonalcoholic fatty liver disease (NAFLD); metabolic
   dysfunction-associated fatty pancreas disease (MAFPD); nonalcoholic
   fatty pancreas disease (NAFPD); metabolic syndrome (MetS)
ID NONALCOHOLIC FATTY LIVER; ENDOPLASMIC-RETICULUM STRESS; ADIPOSE-TISSUE
   EXPANDABILITY; PANCREATIC STEATOSIS; CELL DYSFUNCTION; DISEASE; OBESITY;
   INFLAMMATION; INSULIN; MAFLD
AB Background and Objective: Obesity is a global health issue closely linked to multiple cardiovascular and metabolic conditions. The renaming of nonalcoholic fatty liver disease (NAFLD) to metabolic dysfunctionassociated fatty liver disease (MAFLD) has sparked discussions about renaming nonalcoholic fatty pancreas disease (NAFPD). This narrative review explores the potential benefits and challenges of renaming NAFPD to metabolic dysfunction-associated fatty pancreas disease (MAFPD) and its potential clinical implications. Methods: The review employs a narrative approach, synthesizing existing literature and expert opinions to evaluate the rationale behind and the possible implications of renaming NAFPD to MAFPD. Key Content and Findings: NAFPD is increasingly recognized worldwide but lacks standardized diagnostic criteria, hindering its independent classification as a disease. Renaming NAFPD to MAFPD may enhance diagnostic accuracy, prognostic prediction, and personalized treatment strategies. It may also facilitate global epidemiological research, data sharing, and collaboration. Major challenges include establishing uniform diagnostic guidelines for promoting and educating about the newly proposed terminology. Conclusions: The proposed renaming from NAFPD to MAFPD may offer promising benefits despite challenges. It may also lead to improved management and understanding of the disease, potentially benefiting global healthcare strategies aimed at addressing obesity-related pancreatic complications.
C1 [Zheng, Wen; Zheng, Ming-Hua] Wenzhou Med Univ, Affiliated Hosp 1, MAFLD Res Ctr, Dept Hepatol, 2 Fuxue Lane, Wenzhou 325000, Peoples R China.
   [Liu, Wen-Yue; Zheng, Ming-Hua] First Affiliated Hosp Wenzhou Med Univ, Dept Pathol, Wenzhou, Peoples R China.
   [Lou, Wenhui] Fudan Univ, Zhongshan Hosp, Dept Pancreat Surg, Shanghai, Peoples R China.
   [Targher, Giovanni] Univ Verona, Dept Med, Verona, Italy.
   [Targher, Giovanni] IRCCS, Sacro Cuore Don Calabria Hosp, Metab Dis Res Unit, Negrar Di Valpolicella, Italy.
   [Byrne, Christopher D.] Univ Hosp Southampton, Southampton Natl Inst Hlth & Care Res, Biomed Res Ctr, Southampton, England.
   [Byrne, Christopher D.] Univ Southampton, Southampton Gen Hosp, Southampton, England.
   [Hegyi, Peter] Semmelweis Univ, Inst Pancreat Dis, Budapest, Hungary.
   [Hegyi, Peter] Semmelweis Univ, Ctr Translat Med, Budapest, Hungary.
   [Hegyi, Peter] Univ Szeged, Interdisciplinary Ctr Excellence Res Dev & Innovat, Translat Pancreatol Res Grp, Szeged, Hungary.
   [Hegyi, Peter] Univ Pecs, Inst Translat Med, Med Sch, Pecs, Hungary.
   [Eslam, Mohammed; George, Jacob] Westmead Hosp, Westmead Inst Med Res, Storr Liver Ctr, Sydney, Australia.
   [Zheng, Ming-Hua] Wenzhou Med Univ, Inst Hepatol, Wenzhou, Peoples R China.
   [Zheng, Ming-Hua] Key Lab Diag & Treatment Dev Chron Liver Dis Zheji, Wenzhou, Peoples R China.
C3 Wenzhou Medical University; Fudan University; University of Verona;
   University of Southampton; Semmelweis University; Semmelweis University;
   Szeged University; University of Pecs; University of Sydney; Westmead
   Institute for Medical Research; NSW Health; Westmead Hospital; Wenzhou
   Medical University
RP Zheng, MH (corresponding author), Wenzhou Med Univ, Affiliated Hosp 1, MAFLD Res Ctr, Dept Hepatol, 2 Fuxue Lane, Wenzhou 325000, Peoples R China.; Zheng, MH (corresponding author), Wenzhou Med Univ, Inst Hepatol, Wenzhou, Peoples R China.; Zheng, MH (corresponding author), Key Lab Diag & Treatment Dev Chron Liver Dis Zheji, Wenzhou, Peoples R China.
EM zhengmh@wmu.edu.cn
RI Zheng, Ming-Hua/H-5584-2019; Liu, Wenyue/KDM-8848-2024; Targher,
   Giovanni/AAB-9008-2019; Hegyi, Péter/B-3163-2016; Eslam,
   Mohammed/JAD-0534-2023
OI Byrne, Christopher D/0000-0001-6322-7753
FU National Natural Science Foundation of China [82070588, 82370577]; High
   Level Creative Talents from Department of Public Health in Zhejiang
   Province [S2032102600032]; National Key R & D Program of China
   [2023YFA1800801]; School of Medicine, University of Verona, Verona,
   Italy; Southampton National Institute for Health and Care Research
   (NIHR) Biomedical Research Centre [NIHR203319]; Robert W. Storr Bequest
   to the Sydney Medical Foundation, University of Sydney; National Health
   and Medical Research Council of Australia (NHMRC) Program Grant
   [APP1053206]; Investigator and MRFF grants [APP2032407, NCRI000183,
   APP2016215, APP 2010795, APP1196492]; Cancer Institute, NSW
   [2021/ATRG2028]
FX This study was funded by grants from the National Natural Science
   Foundation of China (82070588, 82370577) , High Level Creative Talents
   from Department of Public Health in Zhejiang Province (S2032102600032)
   and National Key R & D Program of China (2023YFA1800801) . G.T. is
   supported in part by grants from the School of Medicine, University of
   Verona, Verona, Italy. C.D.B. is supported in part by the Southampton
   National Institute for Health and Care Research (NIHR) Biomedical
   Research Centre (NIHR203319) , UK. J.G. is supported by the Robert W.
   Storr Bequest to the Sydney Medical Foundation, University of Sydney; a
   National Health and Medical Research Council of Australia (NHMRC)
   Program Grant (APP1053206) , Investigator and MRFF grants (APP2032407;
   NCRI000183; APP2016215; APP 2010795; APP1196492) and a Cancer Institute,
   NSW grant (2021/ATRG2028) .
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NR 103
TC 1
Z9 1
U1 6
U2 9
PU AME PUBLISHING COMPANY
PI SHATIN
PA FLAT-RM C 16F, KINGS WING PLAZA 1, NO 3 KWAN ST, SHATIN, HONG KONG
   00000, PEOPLES R CHINA
SN 2304-3881
EI 2304-389X
J9 HEPATOBIL SURG NUTR
JI Hepatobil. Surg. Nutr.
PD 2024 NOV 18
PY 2024
DI 10.21037/hbsn-24-284
EA NOV 2024
PG 15
WC Gastroenterology & Hepatology; Nutrition & Dietetics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Nutrition & Dietetics; Surgery
GA M9R9Z
UT WOS:001360841300001
OA gold
DA 2025-06-11
ER

PT J
AU Du, L
   Zong, Y
   Li, HR
   Wang, QY
   Xie, L
   Yang, B
   Pang, YD
   Zhang, CQ
   Zhong, ZG
   Gao, JJ
AF Du, Lin
   Zong, Yao
   Li, Haorui
   Wang, Qiyue
   Xie, Lei
   Yang, Bo
   Pang, Yidan
   Zhang, Changqing
   Zhong, Zhigang
   Gao, Junjie
TI Hyperuricemia and its related diseases: mechanisms and advances in
   therapy
SO SIGNAL TRANSDUCTION AND TARGETED THERAPY
LA English
DT Review
ID SERUM URIC-ACID; CHRONIC KIDNEY-DISEASE; NITRIC-OXIDE SYNTHASE; NLRP3
   INFLAMMASOME ACTIVATION; RENIN-ANGIOTENSIN-SYSTEM; INDUCED
   GOUTY-ARTHRITIS; VEIN ENDOTHELIAL-CELLS; URATE-LOWERING AGENTS;
   ASYMPTOMATIC HYPERURICEMIA; OXIDATIVE STRESS
AB Hyperuricemia, characterized by elevated levels of serum uric acid (SUA), is linked to a spectrum of commodities such as gout, cardiovascular diseases, renal disorders, metabolic syndrome, and diabetes, etc. Significantly impairing the quality of life for those affected, the prevalence of hyperuricemia is an upward trend globally, especially in most developed countries. UA possesses a multifaceted role, such as antioxidant, pro-oxidative, pro-inflammatory, nitric oxide modulating, anti-aging, and immune effects, which are significant in both physiological and pathological contexts. The equilibrium of circulating urate levels hinges on the interplay between production and excretion, a delicate balance orchestrated by urate transporter functions across various epithelial tissues and cell types. While existing research has identified hyperuricemia involvement in numerous biological processes and signaling pathways, the precise mechanisms connecting elevated UA levels to disease etiology remain to be fully elucidated. In addition, the influence of genetic susceptibilities and environmental determinants on hyperuricemia calls for a detailed and nuanced examination. This review compiles data from global epidemiological studies and clinical practices, exploring the physiological processes and the genetic foundations of urate transporters in depth. Furthermore, we uncover the complex mechanisms by which the UA induced inflammation influences metabolic processes in individuals with hyperuricemia and the association with its relative disease, offering a foundation for innovative therapeutic approaches and advanced pharmacological strategies.
C1 [Du, Lin; Li, Haorui; Wang, Qiyue; Xie, Lei; Yang, Bo; Zhong, Zhigang; Gao, Junjie] Shantou Univ, Affiliated Hosp 1, Sports Med Ctr, Med Coll, Shantou 515041, Peoples R China.
   [Du, Lin; Li, Haorui; Wang, Qiyue; Xie, Lei; Yang, Bo; Zhong, Zhigang; Gao, Junjie] Shantou Univ, Inst Sports Med, Med Coll, Shantou 515041, Peoples R China.
   [Zong, Yao] Univ Western Australia, Ctr Orthopaed Res, Med Sch, Nedlands, WA 6009, Australia.
   [Pang, Yidan; Zhang, Changqing; Gao, Junjie] Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 6, Dept Orthopaed, Sch Med, Shanghai 200233, Peoples R China.
C3 Shantou University; Shantou University; University of Western Australia;
   Shanghai Jiao Tong University
RP Zhong, ZG; Gao, JJ (corresponding author), Shantou Univ, Affiliated Hosp 1, Sports Med Ctr, Med Coll, Shantou 515041, Peoples R China.; Zhong, ZG; Gao, JJ (corresponding author), Shantou Univ, Inst Sports Med, Med Coll, Shantou 515041, Peoples R China.; Zhang, CQ; Gao, JJ (corresponding author), Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 6, Dept Orthopaed, Sch Med, Shanghai 200233, Peoples R China.
EM zhangcq@sjtu.edu.cn; stzzg@163.com; colingjj@163.com
RI Pang, Yidan/JEO-5718-2023; changqing, zhang/JJE-9538-2023; Gao,
   JunJie/JXW-9886-2024
OI Gao, Junjie/0000-0003-4820-8524; Pang, Yidan/0000-0002-2286-1069; DU,
   LIN/0009-0003-6985-6405
FU National Natural Science Foundation of China [82002339, 81820108020];
   Shanghai Frontiers Science Center of Degeneration and Regeneration in
   Skeletal System [BJ1-9000-22-4002]
FX This study was performed with the support of the National Natural
   Science Foundation of China (82002339, 81820108020), Shanghai Frontiers
   Science Center of Degeneration and Regeneration in Skeletal System
   (BJ1-9000-22-4002). BioRender (https://www.biorender.com/) was used to
   create the Figs. 3 and 5.
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NR 465
TC 103
Z9 106
U1 98
U2 149
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 2095-9907
EI 2059-3635
J9 SIGNAL TRANSDUCT TAR
JI Signal Transduct. Target. Ther.
PD AUG 28
PY 2024
VL 9
IS 1
AR 212
DI 10.1038/s41392-024-01916-y
PG 29
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA E0M8F
UT WOS:001300041900001
PM 39191722
OA gold
HC Y
HP Y
DA 2025-06-11
ER

PT J
AU Bloomingdale, P
   Karelina, T
   Ramakrishnan, V
   Bakshi, S
   Véronneau-Veilleux, F
   Moye, M
   Sekiguchi, K
   Meno-Tetang, G
   Mohan, A
   Maithreye, R
   Thomas, VA
   Gibbons, F
   Cabal, A
   Bouteiller, JM
   Geerts, H
AF Bloomingdale, Peter
   Karelina, Tatiana
   Ramakrishnan, Vidya
   Bakshi, Suruchi
   Veronneau-Veilleux, Florence
   Moye, Matthew
   Sekiguchi, Kazutaka
   Meno-Tetang, Guy
   Mohan, Aparna
   Maithreye, R.
   Thomas, Veena A.
   Gibbons, Frank
   Cabal, Antonio
   Bouteiller, Jean-Marie
   Geerts, Hugo
TI Hallmarks of neurodegenerative disease: A systems pharmacology
   perspective
SO CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY
LA English
DT Article
ID UNFOLDED PROTEIN RESPONSE; DEEP BRAIN-STIMULATION; ALZHEIMERS-DISEASE;
   METABOLIC SYNDROME; ALPHA-SYNUCLEIN; INSULIN-RESISTANCE;
   PARKINSONS-DISEASE; ER STRESS; COGNITIVE PERFORMANCE;
   CEREBROSPINAL-FLUID
AB Age-related central neurodegenerative diseases, such as Alzheimer's and Parkinson's disease, are a rising public health concern and have been plagued by repeated drug development failures. The complex nature and poor mechanistic understanding of the etiology of neurodegenerative diseases has hindered the discovery and development of effective disease-modifying therapeutics. Quantitative systems pharmacology models of neurodegeneration diseases may be useful tools to enhance the understanding of pharmacological intervention strategies and to reduce drug attrition rates. Due to the similarities in pathophysiological mechanisms across neurodegenerative diseases, especially at the cellular and molecular levels, we envision the possibility of structural components that are conserved across models of neurodegenerative diseases. Conserved structural submodels can be viewed as building blocks that are pieced together alongside unique disease components to construct quantitative systems pharmacology (QSP) models of neurodegenerative diseases. Model parameterization would likely be different between the different types of neurodegenerative diseases as well as individual patients. Formulating our mechanistic understanding of neurodegenerative pathophysiology as a mathematical model could aid in the identification and prioritization of drug targets and combinatorial treatment strategies, evaluate the role of patient characteristics on disease progression and therapeutic response, and serve as a central repository of knowledge. Here, we provide a background on neurodegenerative diseases, highlight hallmarks of neurodegeneration, and summarize previous QSP models of neurodegenerative diseases.
C1 [Bloomingdale, Peter; Moye, Matthew] Merck & Co Inc, Quantitat Pharmacol & Pharmacometr, 33 Ave Louis Pasteur, Boston, MA 02115 USA.
   [Karelina, Tatiana] InSysBio, Moscow, Russia.
   [Ramakrishnan, Vidya] Genentech Inc, Clin Pharmacol, San Francisco, CA 94080 USA.
   [Bakshi, Suruchi; Geerts, Hugo] Certara QSP, Oss, Netherlands.
   [Bakshi, Suruchi] Certara QSP, Princeton, NJ USA.
   [Veronneau-Veilleux, Florence] Univ Montreal, Fac Pharm, Montreal, PQ, Canada.
   [Sekiguchi, Kazutaka] Shionogi & Co Ltd, Osaka, Japan.
   [Sekiguchi, Kazutaka] Suny Downstate Med Ctr, New York, NY USA.
   [Meno-Tetang, Guy] AstraZeneca, Neurosci, Biopharmaceut R&D, Cambridge, England.
   [Mohan, Aparna; Maithreye, R.] Vantage Res, Chennai, Tamil Nadu, India.
   [Thomas, Veena A.] Amgen Inc, San Francisco, CA USA.
   [Gibbons, Frank] Biogen, Clin Pharmacol & Pharmacometr, Cambridge, MA USA.
   [Cabal, Antonio] Eisai, Nutley, NJ USA.
   [Bouteiller, Jean-Marie] Viterbi Sch Engn, Ctr Neural Engn, Dept Biomed Engn, Los Angeles, CA USA.
   [Bouteiller, Jean-Marie] Univ Southern Calif, Keck Sch Med, Inst Technol & Med Syst Innovat, Los Angeles, CA 90007 USA.
C3 Merck & Company; Merck & Company USA; Roche Holding; Genentech; Roche
   Holding USA; Universite de Montreal; Shionogi & Company Limited; State
   University of New York (SUNY) System; SUNY Downstate Health Sciences
   University; AstraZeneca; Amgen; Biogen; Eisai Co Ltd; University of
   Southern California
RP Bloomingdale, P (corresponding author), Merck & Co Inc, Quantitat Pharmacol & Pharmacometr, 33 Ave Louis Pasteur, Boston, MA 02115 USA.
EM peterbloomingdale@gmail.com
RI Thomas, Veena/AAO-4647-2021; Bouteiller, Jean-Marie/AFL-4144-2022;
   Bakshi, Suruchi/LSK-2791-2024; Sekiguchi, Kazutaka/LDG-0576-2024
OI Gibbons, Francis/0000-0003-1606-1740; bouteiller,
   jean-marie/0000-0003-3069-0826
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NR 214
TC 21
Z9 23
U1 4
U2 38
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2163-8306
J9 CPT-PHARMACOMET SYST
JI CPT-PHARMACOMET. SYST. PHARMACOL.
PD NOV
PY 2022
VL 11
IS 11
BP 1399
EP 1429
DI 10.1002/psp4.12852
EA JUL 2022
PG 31
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 6D9TD
UT WOS:000883026800002
PM 35894182
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Parsanathan, R
   Jain, SK
AF Parsanathan, Rajesh
   Jain, Sushil K.
TI Novel Invasive and Noninvasive Cardiac-Specific Biomarkers in Obesity
   and Cardiovascular Diseases
SO METABOLIC SYNDROME AND RELATED DISORDERS
LA English
DT Article
DE cardiovascular diseases; cardiac-specific biomarkers; cardiac troponins;
   heart rate variability; natriuretic peptides; childhood obesity
ID HEART-RATE-VARIABILITY; ACUTE MYOCARDIAL-INFARCTION; ISCHEMIA-MODIFIED
   ALBUMIN; MYOSIN LIGHT-CHAIN; ACID-BINDING PROTEIN; PHOSPHORYLASE
   ISOENZYME BB; ATRIAL-NATRIURETIC-PEPTIDE; INTIMA-MEDIA THICKNESS; ACUTE
   CORONARY SYNDROME; ASPARTATE-AMINOTRANSFERASE ISOENZYMES
AB Cardiovascular disease (CVD) is the leading cause of fatality and disability worldwide regardless of gender. Obesity has reached epidemic proportions in population across different regions. According to epidemiological studies, CVD risk markers in childhood obesity are one of the significant risk factors for adulthood CVD, but have received disproportionally little attention. This review has examined the evidence for the presence of traditional cardiac biomarkers (nonspecific; lactate dehydrogenase, alanine aminotransferase, aspartate aminotransferase, creatine kinase, myoglobulin, glycogen phosphorylase isoenzyme BB, myosin light chains, ST2, and ischemia-modified albumin) and novel emerging cardiac-specific biomarkers (cardiac troponins, natriuretic peptides, heart-type fatty acid-binding protein, and miRNAs). Besides, noninvasive anatomical and electrophysiological markers (carotid intima-media thickness, coronary artery calcification, and heart rate variability) in CVDs and obesity are also discussed. Modifiable and nonmodifiable risk factors associated with metabolic syndrome in the progression of CVD, such as obesity, diabetes, hypertension, dyslipidemia, oxidative stress, inflammation, and adipocytokines are also outlined. These underlying prognostic risk factors predict the onset of future microvascular and macrovascular complications. The understanding of invasive and noninvasive cardiac-specific biomarkers and the risk factors may yield valuable insights into the pathophysiology and prevention of CVD in a high-risk obese population at an early stage.
C1 [Parsanathan, Rajesh; Jain, Sushil K.] Louisiana State Univ, Hlth Sci Ctr Shreveport, Dept Pediat, Shreveport, LA 71130 USA.
   [Parsanathan, Rajesh; Jain, Sushil K.] Louisiana State Univ, Hlth Sci Ctr Shreveport, Ctr Cardiovasc Dis & Sci, Shreveport, LA 71130 USA.
C3 Louisiana State University System; Louisiana State University Health
   Sciences Center at Shreveport; Louisiana State University System;
   Louisiana State University Health Sciences Center at Shreveport
RP Jain, SK (corresponding author), Louisiana State Univ, Hlth Sci Ctr Shreveport, Dept Pediat, Shreveport, LA 71130 USA.; Jain, SK (corresponding author), Louisiana State Univ, Hlth Sci Ctr Shreveport, Ctr Cardiovasc Dis & Sci, Shreveport, LA 71130 USA.
EM sjain@lsuhsc.edu
RI Parsanathan, Rajesh/C-2635-2016
FU Center for Cardiovascular Diseases and Sciences (CCDS), Louisiana State
   University Health Sciences Center, Shreveport
FX The authors are supported by grants from the Malcolm W. Feist
   Cardiovascular Research Fellowship to R.P. and Malcolm Feist Endowed
   Chair in Diabetes to S.K.J. from the Center for Cardiovascular Diseases
   and Sciences (CCDS), Louisiana State University Health Sciences Center,
   Shreveport.
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NR 311
TC 55
Z9 57
U1 1
U2 10
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-4196
EI 1557-8518
J9 METAB SYNDR RELAT D
JI Metab. Syndr. Relat. Disord.
PD FEB 1
PY 2020
VL 18
IS 1
BP 10
EP 30
DI 10.1089/met.2019.0073
EA OCT 2019
PG 21
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA KH0HN
UT WOS:000490867600001
PM 31618136
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Lenquiste, SA
   Lamas, CD
   Marineli, RD
   Moraes, EA
   Borck, PC
   Camargo, RL
   Quitete, VHAC
   Carneiro, EM
   Marostica, MR
AF Lenquiste, Sabrina Alves
   Lamas, Celina de Almeida
   Marineli, Rafaela da Silva
   Moraes, Erica Aguiar
   Borck, Patricia Cristine
   Camargo, Rafael Ludemann
   Alves Cagnon Quitete, Valeria Helena
   Carneiro, Everardo Magalhaes
   Marostica Junior, Mario Roberto
TI Jaboticaba peel powder and jaboticaba peel aqueous extract reduces
   obesity, insulin resistance and hepatic fat accumulation in rats
SO FOOD RESEARCH INTERNATIONAL
LA English
DT Article
DE Myrciaria Jaboticaba (Vell.) Berg.; Obesity; Adiposity; Insulin
   resistance; Liver steatosis
ID INDUCED METABOLIC SYNDROME; OXIDATIVE STRESS; VELL. BERG; DIET;
   ANTHOCYANINS; SENSITIVITY; FRUCTOSE; FRUITS; INFLAMMATION; ANTIOXIDANTS
AB This study investigated the effects of freeze-dried jaboticaba peel (FJP) and jaboticaba tea (JE) on obesity parameters of diet-induced obese rats. Thirty-six male Wistar rats were distributed into six groups: AIN-93 M feed a normal control diet; HFF (obese control) feed a high-fat and fructose diet; Prevention FJP (P. FJP) and Treatment FJP (T. FJP) feed HFF diet with 2% of FJP powder, for 12 and 6 weeks respectively; Prevention JE (P. JE) and Treatment JE (T. JE) were feed with HFF diet and the water was substituted by JE, for 12 and 6 weeks, respectively. Lipid profile, glucose, adiponectin and leptin were measured. Glucose and insulin tolerance, also pancreatic islet insulin secretion were determined. Liver morphology and fat liver accumulation were evaluated. Results showed that HFF-diet induced weight gain, dyslipidemia, glucose intolerance, insulin resistance and hepatic steatosis. All FJP and JE treatments reduced weight gain, adiposity and improved insulin sensitivity. Twelve weeks supplementation increased HDL-cholesterol and prevented hepatic steatosis. Our results suggest that FJP and JE act as functional foods, being a dietary strategy to prevent or control obesity. FJP and JE 12 weeks supplementation can modulate important parameters of obesity and insulin metabolism, preventing liver steatosis in obese rats.
C1 [Lenquiste, Sabrina Alves] Univ Oeste Paulista UNOESTE, Fac Nutr, Presidente Prudente, SP, Brazil.
   [Lenquiste, Sabrina Alves; Marineli, Rafaela da Silva; Moraes, Erica Aguiar; Marostica Junior, Mario Roberto] Univ Estadual Campinas, Sch Food Engn, Dept Food & Nutr, 80 Monteiro Lobato St, Campinas, SP, Brazil.
   [Lamas, Celina de Almeida; Borck, Patricia Cristine; Camargo, Rafael Ludemann; Alves Cagnon Quitete, Valeria Helena; Carneiro, Everardo Magalhaes] Univ Estadual Campinas, Inst Biol, Dept Struct & Funct Biol, Bertrand Russel Av, Campinas, SP, Brazil.
   [Moraes, Erica Aguiar] Univ Fed Espirito Santo, Dept Integrated Educ, Vitoria, ES, Brazil.
C3 Universidade do Oeste Paulista; Universidade Estadual de Campinas;
   Universidade de Sao Paulo; Universidade Estadual de Campinas;
   Universidade Federal do Espirito Santo
RP Lenquiste, SA (corresponding author), Univ Oeste Paulista UNOESTE, Fac Nutr, Presidente Prudente, SP, Brazil.
EM sabrina_nutri28@yahoo.com.br
RI Cagnon, Valéria/B-1638-2013; Camargo, Rafael/G-8330-2015; Marostica,
   Mario/P-5936-2018; Carneiro, Everardo/D-4758-2012
OI Cagnon, Valeria/0000-0001-5331-7376
FU Brazilian National Council for Scientific and Technological Development
   [CNPq 140387/2012-9, 301108/2016-1]
FX This work was supported by the Brazilian National Council for Scientific
   and Technological Development (CNPq 140387/2012-9 and 301108/2016-1).
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NR 46
TC 35
Z9 36
U1 0
U2 38
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0963-9969
EI 1873-7145
J9 FOOD RES INT
JI Food Res. Int.
PD JUN
PY 2019
VL 120
BP 880
EP 887
DI 10.1016/j.foodres.2018.11.053
PG 8
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA HX2AY
UT WOS:000467195400093
PM 31000309
DA 2025-06-11
ER

PT J
AU Gonzalez-Granda, A
   Damms-Machado, A
   Basrai, M
   Bischoff, SC
AF Gonzalez-Granda, Anita
   Damms-Machado, Antje
   Basrai, Maryam
   Bischoff, Stephan C.
TI Changes in Plasma Acylcarnitine and Lysophosphatidylcholine Levels
   Following a High-Fructose Diet: A Targeted Metabolomics Study in Healthy
   Women
SO NUTRIENTS
LA English
DT Article
DE fructose; targeted metabolomics; metabolic syndrome; liver disease
ID GLUCOSE-SWEETENED BEVERAGES; FATTY LIVER-DISEASE; INSULIN-RESISTANCE;
   MASS-SPECTROMETRY; CORN SYRUP; PHOSPHOLIPASE A(2); OXIDATIVE STRESS;
   LIPID-METABOLISM; WEIGHT-GAIN; CONSUMPTION
AB Background: The consumption of high amounts of fructose is associated with metabolic diseases. However, the underlying mechanisms are largely unknown. Objective: To determine the effects of high fructose intake on plasma metabolomics. Study design: We enrolled 12 healthy volunteers (six lean and six obese women, age 24-35 years) in a crossover intervention study. All participants carried out three diets: (1) low fructose (<10 g/day); (2) high fructose (100 g/day) from natural food sources (fruit); and (3) high fructose (100 g/day) from high fructose syrup (HFS). Outcome measures: The primary outcome was changes in plasma metabolites measured by targeted metabolomics. Results: High compared to low fructose diets caused a marked metabolite class separation, especially because of changes in acylcarnitine and lysophosphatidylcholine levels. Both high fructose diets resulted in a decrease in mean acylcarnitine levels in all subjects, and an increase in mean lysophosphatidylcholine and diacyl-phosphatidylcholine levels in obese individuals. Medium chain acylcarnitines were negatively correlated with serum levels of liver enzymes and with the fatty liver index. Discussion: The metabolic shifts induced by high fructose consumption suggest an inhibition of mitochondrial -oxidation and an increase in lipid peroxidation. The effects tended to be more pronounced following the HFS than the fruit diet.
C1 [Gonzalez-Granda, Anita; Damms-Machado, Antje; Basrai, Maryam; Bischoff, Stephan C.] Univ Hohenheim, Inst Clin Nutr, Fruwirthstr 12, D-70599 Stuttgart, Germany.
C3 University Hohenheim
RP Bischoff, SC (corresponding author), Univ Hohenheim, Inst Clin Nutr, Fruwirthstr 12, D-70599 Stuttgart, Germany.
EM anita.gonzalez_granda@uni-hohenheim.de;
   a.damms-machado@uni-hohenheim.de; m.basrai@uni-hohenheim.de;
   bischoff.stephan@uni-hohenheim.de
FU Competence Network of Obesity, group "Obesity and GI tract" - Federal
   Ministry of Education and Research [FKZ: 01GI0843]
FX This work was supported in part with grants from the Competence Network
   of Obesity, group "Obesity and GI tract", funded by the Federal Ministry
   of Education and Research (FKZ: 01GI0843). The funders had no role in
   study design, data collection and analysis, decision to publish, or
   preparation of the manuscript.
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NR 64
TC 31
Z9 31
U1 4
U2 17
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD SEP
PY 2018
VL 10
IS 9
AR 1254
DI 10.3390/nu10091254
PG 19
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA GY5YI
UT WOS:000448659900127
PM 30200659
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Becker, W
AF Becker, Walter
TI A wake-up call to quiescent cancer cells - potential use of DYRK1B
   inhibitors in cancer therapy
SO FEBS JOURNAL
LA English
DT Review
DE cancer therapy; chemoresistance; DYRK1B; kinase inhibitor; quiescence
ID PROTEIN-KINASES; MIRK/DYRK1B KINASE; DREAM COMPLEX; METABOLIC SYNDROME;
   PANCREATIC-CANCER; NEURONAL DIFFERENTIATION; PHOSPHORYLATION SITE;
   BREAST-CANCER; CYCLIN D1; SURVIVAL
AB Nondividing cancer cells are relatively resistant to chemotherapeutic drugs and environmental stress factors. Promoting cell cycle re-entry of quiescent cancer cells is a potential strategy to enhance the cytotoxicity of agents that target cycling cells. It is therefore important to elucidate the mechanisms by which these cells are maintained in the quiescent state. The protein kinase dual specificity tyrosine phosphorylation-regulated kinase 1B (DYRK1B) is overexpressed in a subset of cancers and maintains cellular quiescence by counteracting G(0)/G(1)-S phase transition. Specifically, DYRK1B controls the S phase checkpoint by stabilizing the cyclin-dependent kinase (CDK) inhibitor p27(Kip1) and inducing the degradation of cyclin D. DYRK1B also stabilizes the DREAM complex that represses cell cycle gene expression in G(0) arrested cells. In addition, DYRK1B enhances cell survival by upregulating antioxidant gene expression and reducing intracellular levels of reactive oxygen species (ROS). Substantial evidence indicates that depletion or inhibition of DYRK1B drives cell cycle re-entry and enhances apoptosis of those quiescent cancer cells with high expression of DYRK1B. Furthermore, small molecule DYRK1B inhibitors sensitize cells to the cytotoxic effects of anticancer drugs that target proliferating cells. These encouraging findings justify continued efforts to investigate the use of DYRK1B inhibitors to disrupt the quiescent state and overturn chemoresistance of noncycling cancer cells.
C1 [Becker, Walter] Rhein Westfal TH Aachen, Fac Med, Inst Pharmacol & Toxicol, Aachen, Germany.
C3 RWTH Aachen University
RP Becker, W (corresponding author), Rhein Westfal TH Aachen, Inst Pharmacol & Toxicol, Wendlingweg 2, D-52074 Aachen, Germany.
EM wbecker@ukaachen.de
RI Becker, Walter/B-8889-2008
OI Becker, Walter/0000-0002-0347-4768
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NR 75
TC 50
Z9 54
U1 0
U2 15
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-464X
EI 1742-4658
J9 FEBS J
JI FEBS J.
PD APR
PY 2018
VL 285
IS 7
BP 1203
EP 1211
DI 10.1111/febs.14347
PG 9
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA GC7ZF
UT WOS:000430012000003
PM 29193696
OA Bronze
DA 2025-06-11
ER

PT J
AU Al-Safi, ZA
   Polotsky, A
   Chosich, J
   Roth, L
   Allshouse, AA
   Bradford, AP
   Santoro, N
AF Al-Safi, Zain A.
   Polotsky, Alex
   Chosich, Justin
   Roth, Lauren
   Allshouse, Amanda A.
   Bradford, Andrew P.
   Santoro, Nanette
TI Evidence for disruption of normal circadian cortisol rhythm in women
   with obesity
SO GYNECOLOGICAL ENDOCRINOLOGY
LA English
DT Article
DE Obesity; cortisol; gonadotropins; insulin; stress
ID PITUITARY-ADRENAL AXIS; BODY-FAT DISTRIBUTION; ADRENOCORTICAL FUNCTION;
   METABOLIC SYNDROME; ABDOMINAL OBESITY; MEN; DYSREGULATION; SECRETION;
   FOOD
AB Hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis may play a role in the pathogenesis of comorbidities encountered in obesity, including the relative hypogonadotropic hypogonadism that we and others have observed. We sought to examine serum cortisol profiles throughout the day and evening in a sample of normal weight women and women with obesity. In this cross-sectional study, regularly cycling obese (n=12) and normal weight (n=10) women were recruited. Mean serum cortisol was measured by frequent blood sampling for 16h (8am-midnight) in the luteal phase of the menstrual cycle. Women with obesity had significantly higher overall cortisol levels when compared to normal weight women (6.2 [4.3, 6.6] vs. 4.7 [3.7, 5.5] ug/dl, p=.04). Over the two-hour postprandial period, obese women displayed an almost two-fold greater (7.2 [6.5, 8.6] ug/dl) rise in cortisol than normal weight controls (4.4 [3.7, 6.2] ug/dl, p<.01). In addition, obese women demonstrated a sustained evening cortisol elevation compared to normal weight women, who displayed the typical decline in cortisol (3.2 [2.3, 4] vs. 2 [1.5, 3.2] ug/dl, p<.05). Changes in the HPA axis in the setting of obesity may be related to risks of obesity-associated metabolic comorbidities and reproductive dysfunction often seen in these women.
C1 [Al-Safi, Zain A.; Polotsky, Alex; Chosich, Justin; Roth, Lauren; Bradford, Andrew P.; Santoro, Nanette] Univ Colorado, Sch Med, Dept Obstet & Gynecol, Aurora, CO USA.
   [Allshouse, Amanda A.] Colorado Sch Publ Hlth, Dept Biostat & Informat, Aurora, CO USA.
C3 University of Colorado System; University of Colorado Anschutz Medical
   Campus; Colorado School of Public Health
RP Al-Safi, ZA (corresponding author), Univ Calif Los Angeles, Dept Obstet & Gynecol, 10833 Le Conte Ave,Room 27-139 CHS, Los Angeles, CA 90095 USA.
EM zalsafi@mednet.ucla.edu
FU National Institutes of Health [U54HD058155, RR025780]
FX This work was supported by the National Institutes of Health [grant
   numbers U54HD058155 and RR025780]
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NR 26
TC 13
Z9 14
U1 0
U2 5
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0951-3590
EI 1473-0766
J9 GYNECOL ENDOCRINOL
JI Gynecol. Endocrinol.
PY 2018
VL 34
IS 4
BP 336
EP 340
DI 10.1080/09513590.2017.1393511
PG 5
WC Endocrinology & Metabolism; Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Obstetrics & Gynecology
GA GB1MC
UT WOS:000428813900018
PM 29068243
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Kim, JI
AF Kim, Jee In
TI High fat diet confers vascular hyper-contractility against angiotensin
   II through upregulation of MLCK and CPI-17
SO KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY
LA English
DT Article
DE Angiontensin II; CPI-17; Hypertension; MLCK; Obesity
ID OBESITY-INDUCED HYPERTENSION; SMOOTH-MUSCLE; ADIPOSE-TISSUE; METABOLIC
   SYNDROME; OXIDATIVE STRESS; BLOOD-PRESSURE; SENSITIVITY; MECHANISM; RATS
AB Obesity is a critical risk factor for the hypertension. Although angiotensin II (Ang II) in obese individuals is known to be upregulated in obesity-induced hypertension, direct evidence that explains the underlying mechanism for increased vascular tone and consequent increase in blood pressure (BP) is largely unknown. The purpose of this study is to investigate the novel mechanism underlying Ang II-induced hyper-contractility and hypertension in obese rats. Eight-week old male Sprague-Dawley rats were fed with 60% fat diet or normal diet for 4 months. Body weight, plasma lipid profile, plasma Ang II level, BP, Ang II-induced vascular contraction, and expression of regulatory proteins modulating vascular contraction with/without Ang II stimulation were measured. As a result, high fat diet (HFD) accelerated age-dependent body weight gaining along with increased plasma Ang II concentration. It also increased BP and Ang II-induced aortic contraction. Basal expression of p-CPI-17 and myosin light chain (MLC) kinase was increased by HFD along with increased phosphorylation of MLC. Ang II-induced phosphorylation of CPI-17 and MLC were also higher in HFD group than control group. In conclusion HFD-induced hypertension is through at least in part by increased vascular contractility via increased expression and activation of contractile proteins and subsequent MLC phosphorylation induced by increased Ang II.
C1 [Kim, Jee In] Keimyung Univ, Sch Med, Dept Mol Med, Daegu 42601, South Korea.
C3 Keimyung University
RP Kim, JI (corresponding author), Keimyung Univ, Sch Med, Dept Mol Med, Daegu 42601, South Korea.
EM jeein.kim@kmu.ac.kr
FU Keimyung University
FX This research was supported by the Bisa Research Grant of Keimyung
   University in 2014.
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NR 33
TC 15
Z9 16
U1 0
U2 12
PU KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY
PI SEOUL
PA C/O EDITORIAL OFFICE, 448-13 SEOKYO-DONG, SEOUL, SOUTH KOREA
SN 1226-4512
EI 2093-3827
J9 KOREAN J PHYSIOL PHA
JI KOREAN J. PHYSIOL. PHARMACOL.
PD JAN
PY 2017
VL 21
IS 1
BP 99
EP 106
DI 10.4196/kjpp.2017.21.1.99
PG 8
WC Pharmacology & Pharmacy; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Physiology
GA EG3TA
UT WOS:000390966400012
PM 28066146
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Miranda, VPN
   Peluzio, MDG
   de Faria, ER
   Franceschini, SDC
   Priore, SE
AF Neves Miranda, Valter Paulo
   Gouveia Peluzio, Maria do Carmo
   de Faria, Eliane Rodrigues
   Castro Franceschini, Sylvia do Carmo
   Priore, Silvia Eloiza
TI Inflammatory markers in relation to body composition, physical activity
   and assessment of nutritional status of the adolescents
SO NUTRICION HOSPITALARIA
LA English
DT Review
DE Inflammation; Cardiovascular Diseases; Body Composition; Physical
   Activity; Adolescents
ID C-REACTIVE PROTEIN; METABOLIC SYNDROME; ENDOTHELIAL FUNCTION;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; OBESITY; OVERWEIGHT; EXERCISE;
   HEART; PREVENTION
AB Introduction: The evaluation of inflammatory markers during adolescence can monitor different stages and manifestation of chronic diseases in adulthood. The control of the subclinical inflammation process through changes in lifestyle, especially in the practice of physical activity and dietary education can mitigate the effects of risk factors that trigger the process of atherosclerosis.
   Objective: To do a critical review regarding inflammatory markers as a risk factor of cardiovascular disease in relation to body composition, physical activity and assessment of nutritional status of adolescents.
   Methods: A literature review was performed in the following electronic databases: PUBMED, SCIELO and CONCHRANE COLLECTION. The following associated terms were used "inflammation AND cardiovascular diseases AND nutritional status OR body composition OR physical activity". There were topics created for the discussion of subjects: obesity and risk factors for cardiovascular disease during adolescence; expression of inflammatory markers in adolescence; development of cardiovascular disease with inflammatory markers, and finally, inflammatory markers, physical activity and nutritional evaluation.
   Results: It was observed that the inflammatory markers may manifest in adolescence and be related to risk factors for cardiovascular diseases. Physical activity and nutritional evaluation featured as non-pharmacological measures to control the incidence of inflammatory markers and cardiovascular risk factor.
   Conclusions: Intervention studies may clarify how the adoption of a more proper lifestyle can influence the inflammatory process.
C1 [Neves Miranda, Valter Paulo; Gouveia Peluzio, Maria do Carmo; Castro Franceschini, Sylvia do Carmo; Priore, Silvia Eloiza] Univ Fed Vicosa, Grad Program Nutr Sci, Vicosa, MG, Brazil.
   [de Faria, Eliane Rodrigues] Univ Fed Espirito Santo, Vitoria, ES, Brazil.
C3 Universidade Federal de Vicosa; Universidade Federal do Espirito Santo
RP Miranda, VPN (corresponding author), Dept Nutr & Hlth CCBII, Grad Program Nutr Sci, Campus Univ, BR-36570900 Vicosa, MG, Brazil.
EM vpnmiranda@yahoo.com.br
OI PELUZIO, MARIA DO CARMO GOUVEIA/0000-0003-4665-7043
FU FAPEMIG - Foundation Support Research of Minas Gerais Research; CNPq -
   National Council for Scientific and Technological Development
FX FAPEMIG - Foundation Support Research of Minas Gerais Research and CNPq
   - National Council for Scientific and Technological Development.
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NR 55
TC 6
Z9 8
U1 0
U2 15
PU ARAN EDICIONES, S L
PI MADRID
PA C/ CASTELLO, 128, 1O, MADRID, 28006, SPAIN
SN 0212-1611
EI 1699-5198
J9 NUTR HOSP
JI Nutr. Hosp.
PD MAY
PY 2015
VL 31
IS 5
BP 1920
EP 1927
DI 10.3305/nh.2015.31.5.8586
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA CH7QH
UT WOS:000354231200004
PM 25929359
DA 2025-06-11
ER

PT J
AU Li, CJ
   Yang, F
   Yuan, ZH
   Wei, XG
AF Li, Changjin
   Yang, Fan
   Yuan, Zuohui
   Wei, Xiaoguo
TI Review of roles of RNA-binding proteins on NAFLD and the related
   pharmaceutical measures
SO BIOMOLECULES AND BIOMEDICINE
LA English
DT Review; Early Access
DE RNA binding proteins; nonalcoholic fatty liver disease; NAFLD; therapy;
   mechanism
ID FATTY LIVER-DISEASE; LONG NONCODING RNA; ENDOPLASMIC-RETICULUM STRESS;
   SPHINGOSINE KINASE 2; BETA MESSENGER-RNA; AU-RICH ELEMENT; NONALCOHOLIC
   STEATOHEPATITIS; INSULIN-RESISTANCE; HEPATIC STEATOSIS; GENE-EXPRESSION
AB Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide and poses a serious threat to public health. NAFLD is considered a risk factor for metabolic syndrome (MS) and is closely associated with type 2 diabetes mellitus (T2DM), obesity, dyslipidemia, and cardiovascular disease. Recently, increasing attention has been paid to the role of RNA-binding proteins (RBPs) in the pathogenesis of NAFLD. A growing body of research has linked RBPs-such as human antigen R (HuR), sequestosome 1 (p62), polypyrimidine tract-binding protein 1 (PTBP1), and heterogeneous nuclear ribonucleoproteins (hnRNPs)-to lipogenesis and inflammation, both of which contribute to NAFLD through mechanisms involving transcriptional regulation, alternative splicing, RNA stability, polyadenylation, and subcellular localization. However, these findings are often fragmented and lack a comprehensive synthesis. The interactions and mechanisms between RBPs and NAFLD have not yet been thoroughly reviewed. This article provides an overview of the roles and mechanisms of various RBPs in NAFLD, summarizing current knowledge with the aid of figures and tables. In particular, it highlights the influence of HuR on NAFLD through multiple pathways, categorizing its effects based on increased or decreased expression. Furthermore, it reviews drugs that alleviate NAFLD by modulating RBPs, aiming to offer valuable insights for drug-targeted therapies based on RBP regulatory networks.
C1 [Li, Changjin; Yang, Fan; Yuan, Zuohui; Wei, Xiaoguo] Gansu Prov Peoples Hosp, Dept Gastroenterol, Donggang West Rd, Lanzhou 730000, Peoples R China.
RP Li, CJ; Yang, F; Wei, XG (corresponding author), Gansu Prov Peoples Hosp, Dept Gastroenterol, Donggang West Rd, Lanzhou 730000, Peoples R China.
EM elieendoctor@sina.com; 709840183@qq.com; 1322273042@qq.com
FU Natural Science Foundation of Gansu Province of China
   [21JR1RA03,21JR7RA629]
FX Natural Science Foundation of Gansu Province of China (No.
   21JR1RA03,21JR7RA629.
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NR 228
TC 0
Z9 0
U1 0
U2 0
PU ASSOC BASIC MEDICAL SCI FEDERATION BOSNIA & HERZEGOVINA SARAJEVO
PI CEKALUSA
PA UNIV SARAJEVO, MEDICAL FAC, CEKALUSA, SARAJEVO 90, BOSNIA & HERCEG
SN 2831-0896
EI 2831-090X
J9 BIOMOL BIOMED
JI Biomol. Biomed.
PD 2025 MAY 15
PY 2025
DI 10.17305/bb.2025.12465
EA MAY 2025
PG 38
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 2VM4W
UT WOS:001492295400001
PM 40392981
OA gold
DA 2025-06-11
ER

PT J
AU Novi, S
   Vestuto, V
   Campiglia, P
   Tecce, N
   Bertamino, A
   Tecce, MF
AF Novi, Sara
   Vestuto, Vincenzo
   Campiglia, Pietro
   Tecce, Nicola
   Bertamino, Alessia
   Tecce, Mario Felice
TI Anti-Angiogenic Effects of Natural Compounds in Diet-Associated Hepatic
   Inflammation
SO NUTRIENTS
LA English
DT Review
DE liver disease; inflammation; steatosis; ALD; NAFLD; ASH; NASH;
   angiogenesis; hepatocellular carcinoma; natural compounds
ID FATTY LIVER-DISEASE; NF-KAPPA-B; OXIDATIVE STRESS; INSULIN-RESISTANCE;
   NONALCOHOLIC STEATOHEPATITIS; INHIBITS ANGIOGENESIS;
   SIGNAL-TRANSDUCTION; GENERAL-POPULATION; STELLATE CELLS; GREEN TEA
AB Alcoholic liver disease (ALD) and non-alcoholic fatty liver disease (NAFLD) are the most common causes of chronic liver disease and are increasingly emerging as a global health problem. Such disorders can lead to liver damage, resulting in the release of pro-inflammatory cytokines and the activation of infiltrating immune cells. These are some of the common features of ALD progression in ASH (alcoholic steatohepatitis) and NAFLD to NASH (non-alcoholic steatohepatitis). Hepatic steatosis, followed by fibrosis, lead to a continuous progression accompanied by angiogenesis. This process creates hypoxia, which activates vascular factors, initiating pathological angiogenesis and further fibrosis. This forms a vicious cycle of ongoing damage and progression. This condition further exacerbates liver injury and may contribute to the development of comorbidities, such as metabolic syndrome as well as hepatocellular carcinoma. Increasing evidence suggests that anti-angiogenic therapy may have beneficial effects on these hepatic disorders and their exacerbation. Therefore, there is a great interest to deepen the knowledge of the molecular mechanisms of natural anti-angiogenic products that could both prevent and control liver diseases. In this review, we focus on the role of major natural anti-angiogenic compounds against steatohepatitis and determine their potential therapeutic benefits in the treatment of liver inflammation caused by an imbalanced diet.
C1 [Novi, Sara; Vestuto, Vincenzo; Campiglia, Pietro; Bertamino, Alessia; Tecce, Mario Felice] Univ Salerno, Dept Pharm, Via G Paolo II, I-84084 Fisciano, Italy.
   [Tecce, Nicola] Univ Naples Federico II, Med Sch Naples, Dept Clin Med & Surg, Unit Endocrinol, Via Sergio Pansini 5, I-80131 Naples, Italy.
C3 University of Salerno; University of Naples Federico II
RP Tecce, MF (corresponding author), Univ Salerno, Dept Pharm, Via G Paolo II, I-84084 Fisciano, Italy.
EM snovi@unisa.it; vvestuto@unisa.it; pcampiglia@unisa.it;
   nicola.tecce@unina.it; abertamino@unisa.it; tecce@unisa.it
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NR 203
TC 15
Z9 16
U1 3
U2 10
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JUN
PY 2023
VL 15
IS 12
AR 2748
DI 10.3390/nu15122748
PG 23
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA K1YN7
UT WOS:001014469500001
PM 37375652
OA Green Submitted, gold, Green Published
DA 2025-06-11
ER

EF﻿FN Clarivate Analytics Web of Science
VR 1.0
PT J
AU Carrasco, AG
   Izquierdo-Lahuerta, A
   Valverde, AM
   Ni, L
   Flores-Salguero, E
   Coward, RJ
   Medina-Gómez, G
AF Carrasco, Almudena G.
   Izquierdo-Lahuerta, Adriana
   Valverde, Angela M.
   Ni, Lan
   Flores-Salguero, Elena
   Coward, Richard J.
   Medina-Gomez, Gema
TI The protective role of peroxisome proliferator-activated receptor gamma
   in lipotoxic podocytes
SO BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
LA English
DT Article
DE PPARgamma; RXR; Lipid droplets; TZD; Bexarotene; Podocyte
ID BINDING-PROTEIN 4; METABOLIC SYNDROME; VITAMIN-A; AGONIST; INJURY;
   ACCUMULATION; EXPRESSION; DISEASE; KIDNEY; ALPHA
AB Podocytes are specialized epithelial cells that maintain the glomerular filtration barrier. These cells are susceptible to lipotoxicity in the obese state and irreversibly lost during kidney disease leading to proteinuria and renal injury. PPAR gamma is a nuclear receptor whose activation can be renoprotective. This study examined the role of PPAR gamma in the lipotoxic podocyte using a PPAR gamma knockout (PPAR gamma KO) cell line and since the activation of PPAR gamma by Thiazolidinediones (TZD) is limited by their side effects, it explored other alternative therapies to prevent podocyte lipotoxic damage. Wild-type and PPAR gamma KO podocytes were exposed to the fatty acid palmitic acid (PA) and treated with the TZD (Pioglitazone) and/or the Retinoid X receptor (RXR) agonist Bexarotene (BX). It revealed that podocyte PPAR gamma is essential for podocyte function. PPAR gamma deletion reduced key podocyte proteins including podocin and nephrin while increasing basal levels of oxidative and ER stress causing apoptosis and cell death. A combination therapy of low-dose TZD and BX activated both the PPAR gamma and RXR receptors reducing PA-induced podocyte damage. This study confirms the crucial role of PPAR gamma in podocyte biology and that their activation in combination therapy of TZD and BX may be beneficial in the treatment of obesity-related kidney disease.
C1 [Carrasco, Almudena G.; Izquierdo-Lahuerta, Adriana; Flores-Salguero, Elena; Medina-Gomez, Gema] Univ Rey Juan Carlos, Dept Ciencias Bas Salud, Avda Atenas S-N, Alcorcon 28922, Madrid, Spain.
   [Valverde, Angela M.] Inst Biomed Res Alberto Sols CSIC UAM, Madrid 28029, Spain.
   [Valverde, Angela M.] ISCIII, Ctr Invest Biomed Red Diabet & Enfermedades Metab, Madrid 28029, Spain.
   [Valverde, Angela M.; Medina-Gomez, Gema] Univ Rey Juan Carlos, Inst Biomed Res Alberto Sols CSIC, MEMORISM Res Unit, Madrid, Spain.
   [Ni, Lan; Coward, Richard J.] Univ Bristol, Bristol Renal, Translat Hlth Sci, Bristol, England.
C3 Universidad Rey Juan Carlos; Consejo Superior de Investigaciones
   Cientificas (CSIC); CSIC - Instituto de Investigaciones Biomedicas
   Alberto Sols (IIBM); CIBER - Centro de Investigacion Biomedica en Red;
   CIBERDEM; Instituto de Salud Carlos III; Universidad Rey Juan Carlos;
   University of Bristol
RP Izquierdo-Lahuerta, A; Medina-Gómez, G (corresponding author), Univ Rey Juan Carlos, Dept Ciencias Bas Salud, Avda Atenas S-N, Alcorcon 28922, Madrid, Spain.; Medina-Gómez, G (corresponding author), Univ Rey Juan Carlos, Inst Biomed Res Alberto Sols CSIC, MEMORISM Res Unit, Madrid, Spain.
EM adriana.izquierdo@urjc.es
RI GarciaCarrasco, Almudena/LNQ-2317-2024; Medina-Gomez, Gema/F-5667-2016
OI Medina-Gomez, Gema/0000-0001-8169-681X; Coward,
   Richard/0000-0001-6183-2546; Garcia Carrasco,
   Almudena/0000-0002-5679-3797; Flores Salguero, Elena/0000-0001-7727-0066
FU Mobility stays abroad Jose Castillejo for young doctors of Ministerio de
   Educacion Cultura y Deporte de Espana [CAS 12/00160]; Ministerio de
   Economia y Competitividad de Espana [BFU2016-78951-R, BFU2017-
   90578-REDT]; Ministerio de Ciencia e Innovacion [PID2020-116875RB- I00];
   Comunidad de Madrid (Spain) [S2017/BMD-3684, P2022/BMD-7227]; British
   Medical Research Council (MRC) [MR/K010492/1]; MRC [MR/K010492/1,
   MR/T002263/1, MR/W019582/1] Funding Source: UKRI
FX Research conducted for this publication was supported by the Mobility
   stays abroad Jose Castillejo for young doctors of Ministerio de
   Educacion Cultura y Deporte de Espana [CAS 12/00160], Ministerio de
   Economia y Competitividad de Espana [BFU2016-78951-R, BFU2017-
   90578-REDT], Ministerio de Ciencia e Innovacion [PID2020-116875RB- I00],
   Comunidad de Madrid (Spain) [S2017/BMD-3684, P2022/BMD-7227]. RJC was
   supported by the British Medical Research Council (MRC) with a Senior
   Clinical Fellowship [MR/K010492/1].
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NR 54
TC 4
Z9 4
U1 0
U2 0
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1388-1981
EI 1879-2618
J9 BBA-MOL CELL BIOL L
JI Biochim. Biophys. Acta Mol. Cell Biol. Lipids
PD JUL
PY 2023
VL 1868
IS 7
AR 159329
DI 10.1016/j.bbalip.2023.159329
EA MAY 2023
PG 14
WC Biochemistry & Molecular Biology; Biophysics; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Cell Biology
GA J1KU6
UT WOS:001007273200001
PM 37156296
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Panknin, TM
   Howe, CL
   Hauer, M
   Bucchireddigari, B
   Rossi, AM
   Funk, JL
AF Panknin, Timothy M.
   Howe, Carol L.
   Hauer, Meg
   Bucchireddigari, Bhanu
   Rossi, Anthony M.
   Funk, Janet L.
TI Curcumin Supplementation and Human Disease: A Scoping Review of Clinical
   Trials
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE curcumin; curcuminoids; turmeric; Curcuma longa L; human clinical
   trials; dietary supplement
ID FATTY LIVER-DISEASE; TYPE-2 DIABETES-MELLITUS; RANDOMIZED
   CONTROLLED-TRIAL; INDUCED OXIDATIVE STRESS; PLACEBO-CONTROLLED TRIAL;
   CHRONIC PULMONARY COMPLICATIONS; RHEUMATOID-ARTHRITIS PATIENTS;
   HIGHLY-BIOAVAILABLE CURCUMIN; OXIDANT-ANTIOXIDANT BALANCE; ACTIVE
   ULCERATIVE-COLITIS
AB Medicinal properties of turmeric (Curcuma longa L.), a plant used for centuries as an anti-inflammatory, are attributed to its polyphenolic curcuminoids, where curcumin predominates. Although "curcumin" supplements are a top-selling botanical with promising pre-clinical effects, questions remain regarding biological activity in humans. To address this, a scoping review was conducted to assess human clinical trials reporting oral curcumin effects on disease outcomes. Eight databases were searched using established guidelines, yielding 389 citations (from 9528 initial) that met inclusion criteria. Half focused on obesity-associated metabolic disorders (29%) or musculoskeletal disorders (17%), where inflammation is a key driver, and beneficial effects on clinical outcomes and/or biomarkers were reported for most citations (75%) in studies that were primarily double-blind, randomized, and placebo-controlled trials (77%, D-RCT). Citations for the next most studied disease categories (neurocognitive [11%] or gastrointestinal disorders [10%], or cancer [9%]), were far fewer in number and yielded mixed results depending on study quality and condition studied. Although additional research is needed, including systematic evaluation of diverse curcumin formulations and doses in larger D-RCT studies, the preponderance of current evidence for several highly studied diseases (e.g., metabolic syndrome, osteoarthritis), which are also clinically common, are suggestive of clinical benefits.
C1 [Panknin, Timothy M.; Hauer, Meg] Univ Arizona, Coll Med, Tucson, AZ 85724 USA.
   [Howe, Carol L.] Univ Arizona Hlth Sci Lib, Tucson, AZ 85724 USA.
   [Bucchireddigari, Bhanu] Univ Arizona, Univ Arizona Canc Ctr, Tucson, AZ 85724 USA.
   [Rossi, Anthony M.] Univ Arizona, Honors Coll, Dept Physiol, Tucson, AZ 85724 USA.
   [Funk, Janet L.] Univ Arizona, Dept Med, Tucson, AZ 85724 USA.
   [Funk, Janet L.] Univ Arizona, Sch Nutr Sci & Wellness, Tucson, AZ 85724 USA.
C3 University of Arizona; University of Arizona Health Sciences; University
   of Arizona; University of Arizona; University of Arizona; University of
   Arizona
RP Funk, JL (corresponding author), Univ Arizona, Dept Med, Tucson, AZ 85724 USA.; Funk, JL (corresponding author), Univ Arizona, Sch Nutr Sci & Wellness, Tucson, AZ 85724 USA.
EM jfunk@arizona.edu
FU NIH/NHLBI [T35HL007479]; NIH/NIAMS [R21AR078424]
FX NIH/NHLBI T35HL007479 (to TMP and MH). NIH/NIAMS R21AR078424 (to JLF).
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NR 431
TC 42
Z9 44
U1 4
U2 19
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD MAR
PY 2023
VL 24
IS 5
AR 4476
DI 10.3390/ijms24054476
PG 32
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 9T8SI
UT WOS:000947292100001
PM 36901908
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Herrera-Martínez, AD
   Herrero-Aguayo, V
   Pérez-Gómez, JM
   Gahete, MD
   Luque, RM
AF Herrera-Martinez, Aura D.
   Herrero-Aguayo, Vicente
   Perez-Gomez, Jesus M.
   Gahete, Manuel D.
   Luque, Raul M.
TI Inflammasomes: Cause or consequence of obesity-associated comorbidities
   in humans
SO OBESITY
LA English
DT Review
ID SUBCUTANEOUS ADIPOSE-TISSUE; C-REACTIVE PROTEIN; BODY-MASS INDEX; NLRP3
   INFLAMMASOME; WEIGHT-LOSS; INSULIN SENSITIVITY; IMMUNE-SYSTEM;
   INTERLEUKIN-18 LEVELS; BARIATRIC SURGERY; OXIDATIVE STRESS
AB Inflammasomes are multiprotein intracellular complexes composed of innate immune system receptors and sensors; they activate the inflammatory cascade in response to infectious microbes and/or molecules derived from host proteins. Because of cytokine secretion, inflammasomes can induce amplified systemic responses, its dysregulation can exacerbate symptoms in infectious diseases, and it has been related to the development of autoimmune diseases, inflammatory disorders, and even cancer. Obesity is associated with a chronic low-grade inflammation, in which circulating proinflammatory cytokines are elevated. Some publications describe changes in inflammation markers as a consequence of obesity, but others suggest that chronic inflammation might cause obesity (e.g., C-reactive protein): these assumptions reflect the difficulty of identifying the appropriate role of inflammation as cause or consequence of obesity and its related complications. Obesity is recognized as a clinical risk factor for developing cardiovascular diseases including atherosclerosis, metabolic syndrome, insulin resistance, and diabetes mellitus. Changes in the expression of inflammasomes are described in some of these obesity-related complications, and moreover, its modulation might exert a beneficial effect in some cases. Despite some contradictory results, most publications suggest a promising clinical effect based on in vitro and in vivo experiments. In this review, we summarized recent publications about inflammasome dysregulation in humans and its relationship with obesity-related comorbidities.
C1 [Herrera-Martinez, Aura D.] Reina Sofia Univ Hosp, Endocrinol & Nutr Serv, Cordoba, Spain.
   [Herrera-Martinez, Aura D.; Herrero-Aguayo, Vicente; Perez-Gomez, Jesus M.; Gahete, Manuel D.; Luque, Raul M.] Maimonides Inst Biomed Res Cordoba, Edificio IMIBIC,Av Menendez Pidal S-N, Cordoba 14004, Spain.
   [Herrero-Aguayo, Vicente; Perez-Gomez, Jesus M.; Gahete, Manuel D.; Luque, Raul M.] Univ Cordoba, Dept Cell Biol Physiol & Immunol, Cordoba, Spain.
   [Herrero-Aguayo, Vicente; Perez-Gomez, Jesus M.; Gahete, Manuel D.; Luque, Raul M.] Ctr Invest Biomed Red Fisiopatol Obesidad & Nutr, Cordoba, Spain.
C3 Universidad de Cordoba; CIBER - Centro de Investigacion Biomedica en
   Red; CIBEROBN
RP Herrera-Martínez, AD; Luque, RM (corresponding author), Maimonides Inst Biomed Res Cordoba, Edificio IMIBIC,Av Menendez Pidal S-N, Cordoba 14004, Spain.
EM aurita.dhm@gmail.com; bc2luhur@uco.es
RI Pérez Gómez, Jesús Miguel/JDD-0728-2023; Gahete, Manuel/C-4969-2009;
   Raul, Luque/M-6948-2018
OI Perez Gomez, Jesus Miguel/0000-0003-1785-9797
FU Junta de Andalucia [BIO0139, PI-0038-2019]; Instituto de Salud Carlos
   III [JR19/00050]; Fundacion Espanola de Investigacion Osea y del
   Metabolismo Mineral (FEIOMM); CIBERobn; MINECO/MECD
   [PID2019-105564RB-I00, FPU16/06190, FPU18/06009]
FX This work was funded by Junta de Andalucia (PI-0038-2019, BIO-0139),
   Instituto de Salud Carlos III: JR19/00050, MINECO/MECD
   (PID2019-105564RB-I00, FPU16/06190, FPU18/06009), Junta de Andalucia
   (BIO0139), Fundacion Espanola de Investigacion Osea y del Metabolismo
   Mineral (FEIOMM; Traslational Research Grant 2019), and CIBERobn. CIBER
   is an initiative of Instituto de Salud Carlos III, Ministerio de
   Sanidad, Servicios Sociales e Igualdad, Spain.
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NR 125
TC 16
Z9 16
U1 0
U2 8
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1930-7381
EI 1930-739X
J9 OBESITY
JI Obesity
PD DEC
PY 2022
VL 30
IS 12
BP 2351
EP 2362
DI 10.1002/oby.23581
PG 12
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 6M0KC
UT WOS:000888565600004
PM 36415999
DA 2025-06-11
ER

PT J
AU Cahill, T
   Cope, H
   Bass, JJ
   Overbey, EG
   Gilbert, R
   da Silveira, WA
   Paul, AM
   Mishra, T
   Herranz, R
   Reinsch, SS
   Costes, SV
   Hardiman, G
   Szewczyk, NJ
   Tahimic, CGT
AF Cahill, Thomas
   Cope, Henry
   Bass, Joseph J.
   Overbey, Eliah G.
   Gilbert, Rachel
   da Silveira, Willian Abraham
   Paul, Amber M.
   Mishra, Tejaswini
   Herranz, Raul
   Reinsch, Sigrid S.
   Costes, Sylvain, V
   Hardiman, Gary
   Szewczyk, Nathaniel J.
   Tahimic, Candice G. T.
TI Mammalian and Invertebrate Models as Complementary Tools for Gaining
   Mechanistic Insight on Muscle Responses to Spaceflight
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE spaceflight; muscle; transcriptomics; bedrest; hindlimb unloading;
   microgravity; animal models; cross-species comparison
ID SKELETAL-MUSCLE; CAENORHABDITIS-ELEGANS; GENE-EXPRESSION;
   CIRCADIAN-RHYTHMS; LIFE-SPAN; IONIZING-RADIATION; METABOLIC SYNDROME;
   SATELLITE CELLS; RNA-SEQ; PROTEIN
AB Bioinformatics approaches have proven useful in understanding biological responses to spaceflight. Spaceflight experiments remain resource intensive and rare. One outstanding issue is how to maximize scientific output from a limited number of omics datasets from traditional animal models including nematodes, fruitfly, and rodents. The utility of omics data from invertebrate models in anticipating mammalian responses to spaceflight has not been fully explored. Hence, we performed comparative analyses of transcriptomes of soleus and extensor digitorum longus (EDL) in mice that underwent 37 days of spaceflight. Results indicate shared stress responses and altered circadian rhythm. EDL showed more robust growth signals and Pde2a downregulation, possibly underlying its resistance to atrophy versus soleus. Spaceflight and hindlimb unloading mice shared differential regulation of proliferation, circadian, and neuronal signaling. Shared gene regulation in muscles of humans on bedrest and space flown rodents suggest targets for mitigating muscle atrophy in space and on Earth. Spaceflight responses of C. elegans were more similar to EDL. Discrete life stages of D. melanogaster have distinct utility in anticipating EDL and soleus responses. In summary, spaceflight leads to shared and discrete molecular responses between muscle types and invertebrate models may augment mechanistic knowledge gained from rodent spaceflight and ground-based studies.
C1 [Cahill, Thomas; da Silveira, Willian Abraham; Hardiman, Gary] Queens Univ Belfast, Sch Biol Sci, Belfast BT9 5DL, Antrim, North Ireland.
   [Cahill, Thomas; da Silveira, Willian Abraham; Hardiman, Gary] Queens Univ Belfast, Inst Global Food Secur, Belfast BT9 5DL, Antrim, North Ireland.
   [Cope, Henry] Univ Nottingham, Nottingham Biomed Res Ctr BRC, Sch Comp Sci, Nottingham NG7 2QL, England.
   [Bass, Joseph J.; Szewczyk, Nathaniel J.] Univ Nottingham, MRC Versus Arthrit Ctr Musculoskeletal Ageing Res, Nottingham Biomed Res Ctr BRC, Nottingham NG7 2QL, England.
   [Bass, Joseph J.; Szewczyk, Nathaniel J.] Univ Nottingham, Natl Inst Hlth Res NIHR, Nottingham Biomed Res Ctr BRC, Nottingham NG7 2QL, England.
   [Overbey, Eliah G.] Univ Washington, Dept Genome Sci, Seattle, WA 98195 USA.
   [Gilbert, Rachel; Paul, Amber M.; Reinsch, Sigrid S.; Costes, Sylvain, V; Tahimic, Candice G. T.] NASA, Ames Res Ctr, Space Biosci Div, Moffett Field, CA 94035 USA.
   [Gilbert, Rachel] Univ Space Res Assoc, Columbia, MD 21046 USA.
   [da Silveira, Willian Abraham] Staffordshire Univ, Sch Life Sci & Educ, Dept Biol Sci, Stoke On Trent ST4 2DF, Staffs, England.
   [Paul, Amber M.] Embry Riddle Aeronaut Univ, Dept Human Factors & Behav Neurobiol, Daytona Beach, FL 32114 USA.
   [Paul, Amber M.] Blue Marble Space Inst Sci, Seattle, WA 98104 USA.
   [Mishra, Tejaswini] Stanford Univ, Dept Genet, Sch Med, Palo Alto, CA 94305 USA.
   [Herranz, Raul] CSIC, Ctr Invest Biol Margarita Salas, Ramiro Maeztu 9, Madrid 28040, Spain.
   [Hardiman, Gary] Med Univ South Carolina, Dept Med, Charleston, SC 29425 USA.
   [Szewczyk, Nathaniel J.] Ohio Univ, Heritage Coll Osteopath Med, Dept Biomed Sci, Athens, OH 45701 USA.
   [Tahimic, Candice G. T.] Univ North Florida, Dept Biol, Jacksonville, FL 32224 USA.
C3 Queens University Belfast; Queens University Belfast; University of
   Nottingham; University of Nottingham; University of Nottingham;
   University of Washington; University of Washington Seattle; National
   Aeronautics & Space Administration (NASA); NASA Ames Research Center;
   Universities Space Research Association (USRA); Staffordshire
   University; Embry-Riddle Aeronautical University; Stanford University;
   Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Centro de
   Investigaciones Biologicas (CIB); Medical University of South Carolina;
   University System of Ohio; Ohio University; State University System of
   Florida; University of North Florida
RP Tahimic, CGT (corresponding author), NASA, Ames Res Ctr, Space Biosci Div, Moffett Field, CA 94035 USA.; Tahimic, CGT (corresponding author), Univ North Florida, Dept Biol, Jacksonville, FL 32224 USA.
EM tcahill01@qub.ac.uk; henry.cope@nottingham.ac.uk;
   joseph.bass2@nottingham.ac.uk; eliah@uw.edu; rachelrgilbertll@gmail.com;
   willian.dasilveira@staffs.ac.uk; amber.paul@erau.edu;
   tejaswini.mishra@stanford.edu; rherranz@cib.csic.es;
   sigrid.reinsch@nasa.gov; sylvain.v.costes@nasa.gov;
   g.hardiman@qub.ac.uk; szewczyk@ohio.edu; c.tahimic@unf.edu
RI Mishra, Tejaswini/D-3528-2018; Silveira, willian/JQW-5358-2023; Herranz,
   Raul/A-6510-2010; Costes, Sylvain/D-2522-2013; Reinsch,
   Sigrid/F-9085-2016
OI Szewczyk, Nathaniel/0000-0003-4425-9746; Tahimic,
   Candice/0000-0001-5862-2652; da Silveira, Willian
   Abraham/0000-0001-6370-2884; Herranz, Raul/0000-0002-0246-9449; Cope,
   Henry/0000-0002-4984-0567; Gilbert, Rachel/0000-0002-1380-8012;
   Hardiman, Gary/0000-0003-4558-0400; Costes, Sylvain/0000-0002-8542-2389;
   Bass, Joseph/0000-0002-8236-681X; Reinsch, Sigrid/0000-0002-6484-7521;
   Overbey, Eliah G/0000-0002-2866-8294
FU NI Department for the Economy (DfE) Research Studentship; Horizon Centre
   for Doctoral Training at the University of Nottingham [EP/S023305/1];
   Spanish Plan Estatal de Investigacion Cientifica y Desarrollo
   Tecnologico [RTI2018-099309-B-I00]; NASA Ames Space Biology Program
FX T.C. was supported by the NI Department for the Economy (DfE) Research
   Studentship. H.C. is supported by the Horizon Centre for Doctoral
   Training at the University of Nottingham (UKRI grant no. EP/S023305/1).
   R.H. is supported by the Spanish Plan Estatal de Investigacion
   Cientifica y Desarrollo Tecnologico Grant RTI2018-099309-B-I00. S.S.R.
   is supported by the NASA Ames Space Biology Program.
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NR 156
TC 16
Z9 16
U1 1
U2 13
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD SEP
PY 2021
VL 22
IS 17
AR 9470
DI 10.3390/ijms22179470
PG 25
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA UN9KF
UT WOS:000694325100001
PM 34502375
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Vergani, E
   Bruno, C
   Napodano, C
   Gulli, F
   Stefanile, A
   Piunno, G
   Basile, U
   Mancini, A
AF Vergani, Edoardo
   Bruno, Carmine
   Napodano, Cecilia
   Gulli, Francesca
   Stefanile, Annunziata
   Piunno, Gaia
   Basile, Umberto
   Mancini, Antonio
TI Immune dyscrasia in adult growth hormone deficiency: Evaluation of
   hemolytic complement activity (CH50) and IgG subclasses
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Article
DE CH50; GHD; Immunoglobulins; Low grade chronic inflammation; Free light
   chains
ID FREE LIGHT-CHAINS; OXIDATIVE STRESS; FACTOR-I; METABOLIC SYNDROME;
   BLOOD-PRESSURE; GH; SERUM; AXIS; INFLAMMATION; REPLACEMENT
AB CH50 is a screening assay for the activation of the classical complement pathway, the immunoglobulins-mediated one, activated in several inflammatory diseases. Adult growth hormone deficiency (aGHD) is recognized as a chronic inflammatory condition, although poorly evaluated under the profile of inflammatory biomarkers. The aim of this case-control observational study is to analyze CH50 and immunoglobulins G (IgG) subclasses production in aGHD, comparing this condition to healthy controls.
   38 subjects were included and divided as follows: aGHD (n = 18, 6 females and 12 males); healthy controls (n = 20, 10 females and 10 males). GHD was diagnosed with dynamic test using Growth Hormone-Releasing Hormone (GHRH 50 mu g i.v. + arginine 0,5 g/Kg), with a peak GH response < 9 mu g/L when BMI was <30 kg/m(2) or < 4 mu g/L when BMI was >30 kg/m(2). The two groups were evaluated for hormonal and metabolic parameters, CH50 and IgG subtypes.
   IgG1 and IgG2 were significantly higher in controls than in aGHD, while IgG3 and IgG4 showed a trend to higher levels in controls, although not significant. Furthermore, CH50 levels were significantly higher in aGHD.
   These data substantiate the hypothesis of a dyscrasia in IgG subclasses production in aGHD. As IgG levels decrease, CH50 levels do not.
C1 [Vergani, Edoardo; Bruno, Carmine; Piunno, Gaia; Mancini, Antonio] Univ Cattolica Sacro Cuore, Dipartimento Med & Chirurg Traslaz, Rome, Italy.
   [Napodano, Cecilia; Stefanile, Annunziata; Basile, Umberto] Univ Cattolica Sacro Cuore, Dipartimento Sci Biotecnol Base Clin Intensivol &, Rome, Italy.
   [Vergani, Edoardo; Bruno, Carmine; Napodano, Cecilia; Stefanile, Annunziata; Piunno, Gaia; Basile, Umberto; Mancini, Antonio] Fdn Policlin Univ A Gemelli IRCCS, Rome, Italy.
   [Gulli, Francesca] Osped MG Vannini, Rome, Italy.
C3 Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli;
   Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli;
   Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli
RP Basile, U; Mancini, A (corresponding author), Largo A Gemelli 8, I-00168 Rome, Italy.
EM umberto.basile@policlinicogemelli.it; antonio.mancini@unicatt.it
RI Bruno, Carmine/CAA-0347-2022; Vergani, Edoardo/JCE-0461-2023; Napodano,
   Cecilia/AAO-6048-2020; basile, umberto/E-1720-2018
OI Napodano, Cecilia/0000-0002-8720-6284; stefanile,
   Annunziata/0000-0001-9730-5836; Bruno, Carmine/0000-0002-3489-0238;
   mancini, antonio/0000-0002-9417-6810; Vergani,
   Edoardo/0000-0002-8444-0091; basile, umberto/0000-0002-8328-2570
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NR 53
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD NOV
PY 2020
VL 131
AR 110757
DI 10.1016/j.biopha.2020.110757
PG 6
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA OH6KI
UT WOS:000582699600120
PM 33152922
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Koudoufio, M
   Desjardins, Y
   Feldman, F
   Spahis, S
   Delvin, E
   Levy, E
AF Koudoufio, Mireille
   Desjardins, Yves
   Feldman, Francis
   Spahis, Schohraya
   Delvin, Edgard
   Levy, Emile
TI Insight into Polyphenol and Gut Microbiota Crosstalk: Are Their
   Metabolites the Key to Understand Protective Effects against Metabolic
   Disorders?
SO ANTIOXIDANTS
LA English
DT Review
DE dietary polyphenols; metabolites; oxidative stress; inflammation;
   epigenetics; microflora; cardiometabolic complications
ID IN-VITRO METABOLISM; MUSCLE-CELL PROLIFERATION; GRAPE
   VITIS-ROTUNDIFOLIA; BLOOD MONONUCLEAR-CELLS; APPLE PEEL POLYPHENOLS;
   OLIVE OIL POLYPHENOLS; PANCREATIC BETA-CELLS; DIET-INDUCED OBESITY;
   ELLAGIC ACID; PHENOLIC-COMPOUNDS
AB Lifestyle factors, especially diet and nutrition, are currently regarded as essential avenues to decrease modern-day cardiometabolic disorders (CMD), including obesity, metabolic syndrome, type 2 diabetes, and atherosclerosis. Many groups around the world attribute these trends, at least partially, to bioactive plant polyphenols given their anti-oxidant and anti-inflammatory actions. In fact, polyphenols can prevent or reverse the progression of disease processes through many distinct mechanisms. In particular, the crosstalk between polyphenols and gut microbiota, recently unveiled thanks to DNA-based tools and next generation sequencing, unravelled the central regulatory role of dietary polyphenols and their intestinal micro-ecology metabolites on the host energy metabolism and related illnesses. The objectives of this review are to: (1) provide an understanding of classification, structure, and bioavailability of dietary polyphenols; (2) underline their metabolism by gut microbiota; (3) highlight their prebiotic effects on microflora; (4) discuss the multifaceted roles of their metabolites in CMD while shedding light on the mechanisms of action; and (5) underscore their ability to initiate host epigenetic regulation. In sum, the review clearly documents whether dietary polyphenols and micro-ecology favorably interact to promote multiple physiological functions on human organism.
C1 [Koudoufio, Mireille; Feldman, Francis; Spahis, Schohraya; Delvin, Edgard; Levy, Emile] St Justine Univ Hlth Ctr, Res Ctr, Montreal, PQ H3T 1C5, Canada.
   [Koudoufio, Mireille; Feldman, Francis; Spahis, Schohraya; Levy, Emile] Univ Montreal, Dept Nutr, Montreal, PQ H3T 1J4, Canada.
   [Koudoufio, Mireille; Desjardins, Yves; Feldman, Francis; Spahis, Schohraya; Levy, Emile] Laval Univ, Inst Nutr & Funct Foods, Quebec City, PQ G1V 0A6, Canada.
   [Delvin, Edgard] Univ Montreal, Dept Biochem, Montreal, PQ H3T 1J4, Canada.
   [Levy, Emile] Univ Montreal, Dept Pediat, Montreal, PQ H3T 1J4, Canada.
C3 Universite de Montreal; Laval University; Universite de Montreal;
   Universite de Montreal
RP Levy, E (corresponding author), St Justine Univ Hlth Ctr, Res Ctr, Montreal, PQ H3T 1C5, Canada.; Levy, E (corresponding author), Univ Montreal, Dept Nutr, Montreal, PQ H3T 1J4, Canada.; Levy, E (corresponding author), Laval Univ, Inst Nutr & Funct Foods, Quebec City, PQ G1V 0A6, Canada.; Levy, E (corresponding author), Univ Montreal, Dept Pediat, Montreal, PQ H3T 1J4, Canada.
EM mireille.koudoufio@umontreal.ca; yves.desjardins@fsaa.ulaval.ca;
   francis.feldman@umontreal.ca; schohraya.spahis@gmail.com;
   delvine@sympatico.ca; emile.levy@recherche-ste-justine.qc.ca
RI Desjardins, Yves/F-1222-2013
OI Levy, Emile/0000-0001-9983-7027; Delvin, Edgard/0000-0002-3130-7748;
   Feldman, Francis/0000-0003-2758-9305; Spahis,
   Schohraya/0000-0003-4130-4994
FU JA deSeve Research Chair in nutrition [401240871]
FX This work was supported by a grant from the JA deSeve Research Chair in
   nutrition (E.L.) and the NSERC-Diana Food Industrial Chair on prebiotic
   effects of polyphenols (401240871) (E.L. & Y.D.).
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NR 323
TC 88
Z9 89
U1 3
U2 59
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD OCT
PY 2020
VL 9
IS 10
AR 982
DI 10.3390/antiox9100982
PG 50
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA OJ7KO
UT WOS:000584135500001
PM 33066106
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Baye, E
   de Courten, MPJ
   Walker, K
   Ranasinha, S
   Earnest, A
   Forbes, JM
   de Courten, B
AF Baye, Estifanos
   de Courten, Maximilian P. J.
   Walker, Karen
   Ranasinha, Sanjeeva
   Earnest, Arul
   Forbes, Josephine M.
   de Courten, Barbora
TI Effect of dietary advanced glycation end products on inflammation and
   cardiovascular risks in healthy overweight adults: a randomised
   crossover trial
SO SCIENTIFIC REPORTS
LA English
DT Article
ID INSULIN SENSITIVITY; OXIDATIVE STRESS; ENDOTHELIAL FUNCTION; METABOLIC
   SYNDROME; DIABETES-MELLITUS; AGE RESTRICTION; DOUBLE-BLIND; INDIVIDUALS;
   RESISTANCE; REDUCTION
AB Diets high in advanced glycation end products (AGEs) are thought to be detrimental to cardiovascular health. However, there remains uncertainty about the beneficial effect of a low AGE diet on cardiovascular risk factors and inflammatory markers in overweight individuals. We thus performed a randomised, double blind, crossover trial to determine whether consumption of low AGE diets reduce inflammation and cardiovascular risks in overweight and obese otherwise healthy adults. All participants (n = 20) consumed low and high AGE diets alternately for two weeks and separated by a four week washout period. Low AGE diets did not change systolic (p = 0.2) and diastolic blood pressure (p = 0.3), mean arterial pressure (p = 0.8) and pulse pressure (p = 0.2) compared to high AGE diets. Change in total cholesterol (p = 0.3), low-density lipoprotein (p = 0.7), high-density lipoprotein (p = 0.2), and triglycerides (p = 0.4) also did not differ and there was no difference in inflammatory markers: interleukin-6 (p = 0.6), monocyte chemoattractant protein-1 (p = 0.9), tumour necrosis factor a (p = 0.2), C-reactive protein (p = 0.6) and nuclear factor kappa beta (p = 0.2). These findings indicate that consumption of low AGE diets for two weeks did not improve the inflammatory and cardiovascular profiles of overweight and obese adults.
C1 [Baye, Estifanos; Ranasinha, Sanjeeva; de Courten, Barbora] Monash Univ, Monash Ctr Hlth Res & Implementat, Sch Publ Hlth & Prevent Med, Melbourne, Vic, Australia.
   [de Courten, Maximilian P. J.] Victoria Univ, Coll Hlth & Biomed, Ctr Chron Dis, Melbourne, Vic, Australia.
   [Walker, Karen] Monash Univ, Sch Clin Sci, Dept Nutr & Dietet, Melbourne, Vic, Australia.
   [Earnest, Arul] Monash Univ, Sch Publ Hlth & Prevent Med, Biostat Unit, Melbourne, Vic, Australia.
   [Forbes, Josephine M.] Univ Queensland, Mater Clin Sch, Brisbane, Qld, Australia.
   [Forbes, Josephine M.] Univ Queensland, Translat Res Inst, Glycat & Diabet Mater Res Inst, Brisbane, Qld, Australia.
   [de Courten, Barbora] Monash Hlth, Diabet & Vasc Med Unit, Melbourne, Vic, Australia.
C3 Monash University; Victoria University; Monash University; Monash
   University; University of Queensland; University of Queensland; Mater
   Research; Monash Health
RP de Courten, B (corresponding author), Monash Univ, Monash Ctr Hlth Res & Implementat, Sch Publ Hlth & Prevent Med, Melbourne, Vic, Australia.; de Courten, B (corresponding author), Monash Hlth, Diabet & Vasc Med Unit, Melbourne, Vic, Australia.
EM barbora.decourten@monash.edu
RI de Courten, Barbora/B-3308-2012; de Courten, Maximilian/B-3300-2012;
   Forbes, Josephine/A-4569-2012; Earnest, Arul/L-4747-2013
OI de Courten, Maximilian/0000-0001-9997-9359; Forbes,
   Josephine/0000-0002-5595-8174; Baye, Estifanos/0000-0002-2937-356X;
   Earnest, Arul/0000-0003-2693-5034
FU National Health and Medical Research Council of Australia; Diabetes
   Australia Research Trust; Monash Graduate Scholarship; Monash
   International Postgraduate Scholarship; National Heart Foundation
   [100864]; Australian National Health and Medical Research Council
FX This study was supported by grants from the National Health and Medical
   Research Council of Australia and from a Diabetes Australia Research
   Trust Millennium Award. EB is a recipient of Monash Graduate Scholarship
   and Monash International Postgraduate Scholarship. BdC is supported by
   National Heart Foundation Future Leader Fellowship (100864). JMF is
   supported by Fellowship from the Australian National Health and Medical
   Research Council. No funder had any role in the study design, data
   collection, data analysis or interpretation, or writing of the
   manuscript.
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NR 29
TC 42
Z9 43
U1 0
U2 9
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD JUN 23
PY 2017
VL 7
AR 4123
DI 10.1038/s41598-017-04214-6
PG 6
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA EY6UL
UT WOS:000404118700015
PM 28646140
OA Green Published, gold, Green Accepted
DA 2025-06-11
ER

PT J
AU Trnovská, J
   Silhavy, J
   Kuda, O
   Landa, V
   Zídek, V
   Mlejnek, P
   Slimáková, M
   Strnad, H
   Skop, V
   Oliyarnyk, O
   Kazdová, L
   Haluzík, M
   Pravenec, M
AF Trnovska, Jaroslava
   Silhavy, Jans
   Kuda, Ondrej
   Landa, Vladimir
   Zidek, Vaclav
   Mlejnek, Petr
   Slimakova, Miroslava
   Strnad, Hynek
   Skop, Vojtech
   Oliyarnyk, Olena
   Kazdova, Ludmila
   Haluzik, Martin
   Pravenec, Michal
TI Salsalate ameliorates metabolic disturbances by reducing inflammation in
   spontaneously hypertensive rats expressing human C-reactive protein and
   by activating brown adipose tissue in nontransgenic controls
SO PLOS ONE
LA English
DT Article
ID FALSE DISCOVERY RATE; SALICYLATE; OBESITY; ACIDS; DRUG
AB Chronic low-grade inflammation plays an important role in the pathogenesis of insulin resistance. In the current study, we tested the effects of salsalate, a non-steroidal anti-inflammatory drug, in an animal model of inflammation and metabolic syndrome using spontaneously hypertensive rats (SHR) that transgenically express human C-reactive protein (SHR-CRP rats). We treated 15-month-old male transgenic SHR-CRP rats and nontransgenic SHR with salsalate (200 mg/kg/day) mixed as part of a standard diet for 4 weeks. A corresponding untreated control group of male transgenic SHR-CRP and SHR rats were fed a standard diet without salsalate. In the SHR-CRP transgenic strain, salsalate treatment decreased circulating concentrations of the inflammatory markers TNF-alpha and MCP-1, reduced oxidative stress in the liver and kidney, increased sensitivity of skeletal muscles to insulin action and improved tolerance to glucose. In SHR controls with no CRP-induced inflammation, salsalate treatment reduced body weight, decreased concentrations of serum free fatty acids and total and HDL cholesterol and increased palmitate oxidation and incorporation in brown adipose tissue. Salsalate regulated inflammation by affecting the expression of genes from MAPK signalling and NOD-like receptor signalling pathways and lipid metabolism by affecting hepatic expression of genes that favour lipid oxidation from PPAR-alpha signalling pathways. These findings suggest that salsalate has metabolic effects beyond suppressing inflammation.
C1 [Trnovska, Jaroslava; Skop, Vojtech; Oliyarnyk, Olena; Kazdova, Ludmila; Haluzik, Martin] Inst Clin & Expt Med, Ctr Med Expt, Prague, Czech Republic.
   [Silhavy, Jans; Kuda, Ondrej; Landa, Vladimir; Zidek, Vaclav; Mlejnek, Petr; Slimakova, Miroslava; Pravenec, Michal] Czech Acad Sci, Inst Physiol, Prague, Czech Republic.
   [Strnad, Hynek] Czech Acad Sci, Inst Mol Genet, Prague, Czech Republic.
   [Haluzik, Martin] Charles Univ Prague, Fac Med 1, Inst Med Biochem & Lab Diagnost, Prague, Czech Republic.
   [Haluzik, Martin] Gen Univ Hosp, Prague, Czech Republic.
C3 Institute for Clinical & Experimental Medicine (IKEM); Czech Academy of
   Sciences; Institute of Physiology of the Czech Academy of Sciences;
   Czech Academy of Sciences; Institute of Molecular Genetics of the Czech
   Academy of Sciences; Charles University Prague; General University
   Hospital Prague
RP Pravenec, M (corresponding author), Czech Acad Sci, Inst Physiol, Prague, Czech Republic.
EM pravenec@biomed.cas.cz
RI Silhavy, Jan/B-5292-2014; Haluzik, Martin/I-8190-2017; Oliyarnyk,
   Olena/Q-6380-2019; Simakova, Miroslava/R-5367-2019; Pravenec,
   Michal/B-1666-2012; Mlejnek, Petr/C-2305-2012; Kuda, Ondrej/B-7990-2012;
   Skop, Vojtech/LBI-2231-2024
OI Pravenec, Michal/0000-0001-9197-5871; Mlejnek, Petr/0000-0002-4218-8983;
   Kuda, Ondrej/0000-0001-7034-4536; Trnovska,
   Jaroslava/0000-0001-6468-8244; Oliyarnyk, Olena/0000-0002-4912-6187;
   Skop, Vojtech/0000-0002-4685-4429
FU MH CZ - DRO ("Institute for Clinical and Experimental Medicine - IKEM)
   [IN 0002301]; Grant Agency of the Czech Republic [14-04420S]
FX This work was supported by grant MH CZ - DRO ("Institute for Clinical
   and Experimental Medicine - IKEM, IN 0002301") and grant 14-04420S from
   Grant Agency of the Czech Republic.
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NR 39
TC 7
Z9 8
U1 0
U2 9
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JUN 6
PY 2017
VL 12
IS 6
AR e0179063
DI 10.1371/journal.pone.0179063
PG 18
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA EW9YQ
UT WOS:000402875700044
PM 28586387
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Fukuda, T
   Hamaguchi, M
   Kojima, T
   Ohshima, Y
   Ohbora, A
   Kato, T
   Nakamura, N
   Fukui, M
AF Fukuda, Takuya
   Hamaguchi, Masahide
   Kojima, Takao
   Ohshima, Yasuhiro
   Ohbora, Akihiro
   Kato, Takahiro
   Nakamura, Naoto
   Fukui, Michiaki
TI Association between serum γ-glutamyltranspeptidase and atherosclerosis:
   a population-based cross-sectional study
SO BMJ OPEN
LA English
DT Article
ID FATTY LIVER-DISEASE; MODERATE ALCOHOL-CONSUMPTION; WAVE
   VELOCITY-MEASUREMENT; CARDIOVASCULAR-DISEASE; ARTERIAL STIFFNESS;
   METABOLIC SYNDROME; OXIDATIVE STRESS; RISK-FACTOR; TRANSFERASE; ENZYME
AB Objective: The purpose of this study was to determine the relationship between serum gamma-glutamyltranspeptidase (GGT) and brachial-ankle pulse wave velocity (baPWV) as an indicator for atherosclerosis in Japanese men and women after adjusting for fatty liver.
   Design: A cross-sectional study.
   Setting: A health check-up centre in Japan.
   Participants: 912 Japanese men and women aged 24-84 years recruited from people who received a medical health check-up programme with a standardised questionnaire and an automatic waveform analyser to measure baPWV.
   Main outcome measures: We measured serum GGT concentrations and baPWV. Fatty liver was diagnosed by standardised criteria using abdominal ultrasonography. The postmenopausal state was defined as beginning 1 year after the cessation of menses.
   Results: In women, log(2) GGT was positively associated with baPWV (beta=0.11, 95% CI 0.02 to 0.19, p<0.05), independent of age, body mass index, systolic blood pressure, fasting plasma glucose, triglycerides, estimated glomerular filtration rate, fatty liver, menopausal state and parameters of lifestyles. However, in men, the positive association of log(2) GGT with baPWV was not significant (beta=-0.04, 95% CI -0.10 to 0.03, p=0.28) in multivariable linear regression analyses.
   Conclusions: The serum GGT level was associated with baPWV, independently of covariates including fatty liver or menopausal state just in women, but not in men.
C1 [Fukuda, Takuya; Hamaguchi, Masahide; Nakamura, Naoto; Fukui, Michiaki] Kyoto Prefectural Univ Med, Grad Sch Med Sci, Dept Endocrinol & Metab, Kyoto, Japan.
   [Kojima, Takao; Ohshima, Yasuhiro; Ohbora, Akihiro; Kato, Takahiro] Asahi Univ, Murakami Mem Hosp, Dept Gastroenterol, Gifu, Japan.
C3 Kyoto Prefectural University of Medicine; Asahi University
RP Hamaguchi, M (corresponding author), Kyoto Prefectural Univ Med, Grad Sch Med Sci, Dept Endocrinol & Metab, Kyoto, Japan.
EM seele@koto.kpu-m.ac.jp
RI Kato, Takahiro/R-7665-2019
OI Hamaguchi, Masahide/0000-0002-8651-4445; Fukui,
   Michiaki/0000-0003-0903-1797
FU Japan Society for the Promotion of Science [23790791]; Grants-in-Aid for
   Scientific Research [26860502] Funding Source: KAKEN
FX This work was supported by the Young Scientists (B) from Japan Society
   for the Promotion of Science, No.23790791.
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NR 40
TC 22
Z9 22
U1 0
U2 6
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2044-6055
J9 BMJ OPEN
JI BMJ Open
PY 2014
VL 4
IS 10
AR e005413
DI 10.1136/bmjopen-2014-005413
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA AT2OP
UT WOS:000344774500011
PM 25280803
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Ikeda, S
   Maemura, K
AF Ikeda, Satoshi
   Maemura, Koji
TI Ezetimibe and Vascular Endothelial Function
SO CURRENT VASCULAR PHARMACOLOGY
LA English
DT Article
DE Nitric oxide; C-reactive protein; oxidative stress; cardiovascular
   disease; atherosclerosis
ID NITRIC-OXIDE SYNTHASE; DENSITY-LIPOPROTEIN-CHOLESTEROL; C-REACTIVE
   PROTEIN; LIPID-ALTERING EFFICACY; COA REDUCTASE INHIBITORS;
   CORONARY-ARTERY-DISEASE; PROGENITOR CELLS; METABOLIC-SYNDROME;
   DOUBLE-BLIND; HIGH-RISK
AB Hypercholesterolemia is a major risk factor for cardiovascular diseases that has been managed mostly with 3-hydroxy-3-methyl glutaryl coenzyme A reductase inhibitors (statins) that suppress de novo cholesterol synthesis in the liver. Statins also have beneficial pleiotropic effects on the atherosclerotic process that are independent of their ability to lower lipid values. However, the levels of low-density lipoprotein cholesterol (LDL-C) in most hypercholesterolemic patients at high risk for cardiovascular disease do not reach the goals proposed by guidelines even when prescribed with statins. Ezetimibe is a new lipid-lowering agent that blocks the intestinal absorption of dietary and biliary cholesterol and reduces LDL-C levels, especially when combined with statins. However, its effect on cardiovascular events remains unknown. We reviewed the effects of ezetimibe on cardiovascular diseases, in particular, vascular endothelial function, which is initially impaired during the atherogenetic process and is an important predictor of cardiovascular events. The simultaneous inhibition of cholesterol synthesis by statin and of cholesterol absorption by ezetimibe might retard the atherogenetic process. These effects are considered to be mainly mediated by lipid lowering. However, further studies should elucidate the mechanism of the anti-atherosclerotic effects induced by ezetimibe; for instance, whether or not it directly affects atherogenesis independently from its lipid-lowering effects.
C1 [Ikeda, Satoshi; Maemura, Koji] Nagasaki Univ, Dept Cardiovasc Med, Grad Sch Biomed Sci, Nagasaki 8528501, Japan.
C3 Nagasaki University
RP Maemura, K (corresponding author), Nagasaki Univ, Dept Cardiovasc Med, Grad Sch Biomed Sci, 1-7-1 Sakamoto, Nagasaki 8528501, Japan.
EM maemura@nagasaki-u.ac.jp
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NR 137
TC 4
Z9 5
U1 0
U2 2
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1570-1611
EI 1875-6212
J9 CURR VASC PHARMACOL
JI Current Vascular Pharmacology
PD JAN
PY 2011
VL 9
IS 1
BP 87
EP 98
DI 10.2174/157016111793744797
PG 12
WC Pharmacology & Pharmacy; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Cardiovascular System & Cardiology
GA 712HF
UT WOS:000286656200012
PM 21044017
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Lundgren, M
   Burén, J
   Lindgren, P
   Myrnäs, T
   Ruge, T
   Eriksson, JW
AF Lundgren, M.
   Buren, J.
   Lindgren, P.
   Myrnas, T.
   Ruge, T.
   Eriksson, J. W.
TI Sex- and Depot-specific Lipolysis Regulation in Human Adipocytes:
   Interplay between Adrenergic Stimulation and Glucocorticoids
SO HORMONE AND METABOLIC RESEARCH
LA English
DT Article
DE visceral; subcutaneous; adipose tissue; cAMP; dexamethasone
ID ADIPOSE-TISSUE METABOLISM; SENSITIVE LIPASE EXPRESSION; INDUCED
   INSULIN-RESISTANCE; REGIONAL DIFFERENCES; IN-VIVO; RECEPTOR; GLUCOSE;
   OBESE; MECHANISM; PROTEINS
AB The purpose of this investigation was to explore interactions between adrenergic Stimulation, glucocorticoids, and insulin on the lipolytic rate in isolated human adipocytes from subcutaneous and omental fat depots, and to address possible sex differences. Fat biopsies were obtained from 48 nondiabetic subjects undergoing elective abdominal Surgery. Lipolysis rate was measured as glycerol release from isolated cells and proteins involved in lipolysis regulation were assessed by immunoblots. Fasting blood samples were obtained and metabolic and inflammatory, variables were analyzed. In women, the rate of 8-bromo-cAMP- and isoprenaline-stimulated lipolysis was similar to 2- and 1.5-fold higher, respectively, in subcutaneous compared to omental adipocytes, whereas there was no difference between the two depots in men. Dexamethasone treatment increased the ability of 8-bromo-cAMP to stimulate lipolysis in the subcutaneous depot in women, but had no consistent effects in fat cells from men. Protein kinase A, Perilipin A, and hormone sensitive lipase content in adipocytes was not affected by adipose depot, sex, or glucocorticoid treatment. In conclusion, catecholamine and glucocorticoid regulation of lipolysis in isolated human adipocytes differs between adipose tissue depots and also between sexes. These findings may be of relevance for the interaction between endogenous stress hormones and adipose tissue function in visceral adiposity and the metabolic syndrome.
C1 [Lundgren, M.; Buren, J.; Ruge, T.] Umea Univ Hosp, Dept Med, S-90185 Umea, Sweden.
   [Lindgren, P.] Dept Obstet & Gynaecol, Umea, Sweden.
   [Myrnas, T.; Ruge, T.] Umea Univ Hosp, Dept Surg, S-90185 Umea, Sweden.
   [Eriksson, J. W.] AstraZeneca R&D, Molndal, Sweden.
   [Eriksson, J. W.] Sahlgrens Univ Hosp, Lundberg Lab Diabet Res, S-41345 Gothenburg, Sweden.
C3 Umea University; Umea University Hospital; Umea University; Umea
   University Hospital; AstraZeneca; Sahlgrenska University Hospital
RP Lundgren, M (corresponding author), Umea Univ Hosp, Dept Med, Bldg 9A,2nd Floor, S-90185 Umea, Sweden.
EM magdalena.lundgren@medicin.umu.se
RI Eriksson, Jan/AAB-5820-2021; Burén, Jonas/AAH-2787-2021; Ruge,
   Toralph/Q-4289-2017
OI Buren, Jonas/0000-0001-5846-9002; Lindgren, Peter/0000-0001-5493-3402
FU Swedish Research Council [14287]; Swedish Diabetes Association; Faculty
   of Medicine at Umea University; AstraZeneca RD; Novo Nordisk; Sigurd and
   Elsa Golje; Torsten and Ragnar Soderberg foundations
FX Financial support was given by the Swedish Research Council (Medicine,
   project 14287), the Swedish Diabetes Association, the Faculty of
   Medicine at Umea University, AstraZeneca R&D, the Novo Nordisk, the
   Sigurd and Elsa Golje, and the Torsten and Ragnar Soderberg foundations.
   We gratefully acknowledge the assistance of Hjordis Andersson, Frida
   Renstrom, Ewa Stromqvist-Engbo, Kristina Ojbrandt, and the surgeons and
   staff at the Departments of Surgery and Gynecology (C-OP 2 and C-OP 3)
   at the Umea University Hospital for their skilful work and all kinds of
   assistance. We also thank Dr. Peter Naredi and Dr. Anders Sylwan for
   support, and Dr. Cecilia Holm for providing the HSL antibody.
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NR 33
TC 31
Z9 33
U1 0
U2 8
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0018-5043
EI 1439-4286
J9 HORM METAB RES
JI Horm. Metab. Res.
PD DEC
PY 2008
VL 40
IS 12
BP 854
EP 860
DI 10.1055/s-0028-1087168
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 393HR
UT WOS:000262364900005
PM 18819055
DA 2025-06-11
ER

PT J
AU Salek, RM
   Maguire, ML
   Bentley, E
   Rubtsov, DV
   Hough, T
   Cheeseman, M
   Nunez, D
   Sweatman, BC
   Haselden, JN
   Cox, RD
   Connor, SC
   Griffin, JL
AF Salek, R. M.
   Maguire, M. L.
   Bentley, E.
   Rubtsov, D. V.
   Hough, T.
   Cheeseman, M.
   Nunez, D.
   Sweatman, B. C.
   Haselden, J. N.
   Cox, R. D.
   Connor, S. C.
   Griffin, J. L.
TI A metabolomic comparison of urinary changes in type 2 diabetes in mouse,
   rat, and human
SO PHYSIOLOGICAL GENOMICS
LA English
DT Article
DE metabonomics; metabolic syndrome; biofluids; Zucker rat; db/db mouse;
   nuclear magnetic resonance spectroscopy; leptin resistance
ID NUCLEAR-MAGNETIC-RESONANCE; PEROXISOME PROLIFERATION; HUMAN PLASMA;
   ZUCKER RATS; INSULIN; SPECTROSCOPY; NEPHROPATHY; FATTY; PHENOTYPES;
   CLEARANCE
AB Type 2 diabetes mellitus is the result of a combination of impaired insulin secretion with reduced insulin sensitivity of target tissues. There are an estimated 150 million affected individuals worldwide, of whom a large proportion remains undiagnosed because of a lack of specific symptoms early in this disorder and inadequate diagnostics. In this study, NMR-based metabolomic analysis in conjunction with multivariate statistics was applied to examine the urinary metabolic changes in two rodent models of type 2 diabetes mellitus as well as unmedicated human sufferers. The db/db mouse and obese Zucker ( fa/fa) rat have autosomal recessive defects in the leptin receptor gene, causing type 2 diabetes. H-1-NMR spectra of urine were used in conjunction with uni- and multivariate statistics to identify disease-related metabolic changes in these two animal models and human sufferers. This study demonstrates metabolic similarities between the three species examined, including metabolic responses associated with general systemic stress, changes in the TCA cycle, and perturbations in nucleotide metabolism and in methylamine metabolism. All three species demonstrated profound changes in nucleotide metabolism, including that of N-methylnicotinamide and N-methyl-2-pyridone-5-carboxamide, which may provide unique biomarkers for following type 2 diabetes mellitus progression.
C1 Univ Cambridge, Dept Biochem, Cambridge CB2 1QW, England.
   MRC, Mammalian Genet Unit, Harwell, Oxon, England.
   MRC Harwell, Mary Lyon Ctr, Harwell, Oxon, England.
   GlaxoSmithKline, Safety Assessment, Ware, Herts, England.
C3 University of Cambridge; MRC Harwell; GlaxoSmithKline; Glaxosmithkline
   United Kingdom
RP Griffin, JL (corresponding author), Univ Cambridge, Dept Biochem, Bldg O,Downing Site,Tennis Court Rd, Cambridge CB2 1QW, England.
EM jlg40@mole.bio.cam.ac.uk
RI CONNOR, SUSAN/KTI-6230-2024; Salek, Reza/V-9739-2017
OI Salek, Reza/0000-0001-8604-1732; Cox, Roger/0000-0001-7170-5014
FU MRC [MC_U142661184, MC_UP_1502/1, MC_U142670371] Funding Source: UKRI;
   Medical Research Council [MC_U142670371, MC_U142661184, MC_UP_1502/1]
   Funding Source: Medline
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NR 47
TC 344
Z9 376
U1 0
U2 64
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 1094-8341
EI 1531-2267
J9 PHYSIOL GENOMICS
JI Physiol. Genomics
PD APR 24
PY 2007
VL 29
IS 2
BP 99
EP 108
DI 10.1152/physiolgenomics.00194.2006
PG 10
WC Cell Biology; Genetics & Heredity; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Genetics & Heredity; Physiology
GA 180NY
UT WOS:000247373500001
PM 17190852
DA 2025-06-11
ER

PT J
AU Yang, F
   Chen, CS
   Chen, RJ
   Yang, CH
   Liu, ZR
   Wen, L
   Xiao, HF
   Geng, B
   Xia, YY
AF Yang, Fei
   Chen, Changshun
   Chen, Rongjin
   Yang, Chenghui
   Liu, Zirui
   Wen, Lei
   Xiao, Hefang
   Geng, Bin
   Xia, Yayi
TI Unraveling the Potential of SGK1 in Osteoporosis: From Molecular
   Mechanisms to Therapeutic Targets
SO BIOMOLECULES
LA English
DT Review
DE osteoporosis; SGK1; protein kinase; metabolic bone disease; therapeutic
   strategies
ID GLUCOCORTICOID-INDUCIBLE KINASE; THREONINE PROTEIN-KINASE; UBIQUITIN
   LIGASE NEDD4-2; CHRONIC KIDNEY-DISEASE; CELL-SURVIVAL; TRANSCRIPTIONAL
   REGULATION; METABOLIC SYNDROME; SIGNALING PATHWAY; INDUCED APOPTOSIS;
   OXIDATIVE STRESS
AB Osteoporosis (OP) is a prevalent metabolic bone disease, with several million cases of fractures resulting from osteoporosis worldwide each year. This phenomenon contributes to a substantial increase in direct medical expenditures and poses a considerable socioeconomic burden. Despite its prevalence, our understanding of the underlying mechanisms remains limited. Recent studies have demonstrated the involvement of serum glucocorticoid-regulated protein kinase 1 (SGK1) in multiple signaling pathways that regulate bone metabolism and its significant role in the development of osteoporosis. Therefore, it is of great significance to deeply explore the mechanism of SGK1 in osteoporosis and its therapeutic potential. In this paper, we present a comprehensive review of the structure and activation mechanism of SGK1, its biological function, the role of SGK1 in different types of osteoporosis, and the inhibitors of SGK1. The aim is to comprehensively assess the latest research progress with regards to SGK1's role in osteoporosis, clarify its role in the regulation of bone metabolism and its potential as a therapeutic target, and lay the foundation for the development of novel therapeutic strategies and personalized treatment in the future. Furthermore, by thoroughly examining the interactions between SGK1 and other molecules or signaling pathways, potential biomarkers may be identified, thereby enhancing the efficacy of early screening and intervention for osteoporosis.
C1 [Yang, Fei; Chen, Changshun; Chen, Rongjin; Yang, Chenghui; Liu, Zirui; Wen, Lei; Xiao, Hefang; Geng, Bin; Xia, Yayi] Lanzhou Univ, Dept Orthopaed, Hosp 2, Lanzhou 730030, Peoples R China.
   [Yang, Fei; Chen, Changshun; Chen, Rongjin; Yang, Chenghui; Liu, Zirui; Wen, Lei; Xiao, Hefang; Geng, Bin; Xia, Yayi] Lanzhou Univ, Clin Med Sch 2, Lanzhou 730030, Peoples R China.
   [Yang, Fei] Nanchong Cent Hosp, Dept Orthoped, Nanchong 637000, Peoples R China.
   [Chen, Changshun; Wen, Lei] Yunnan Univ, Affiliated Hosp, Dept Orthoped & Trauma Surg, Kunming 650032, Peoples R China.
C3 Lanzhou University; Lanzhou University; North Sichuan Medical
   University; Yunnan University
RP Xia, YY (corresponding author), Lanzhou Univ, Dept Orthopaed, Hosp 2, Lanzhou 730030, Peoples R China.; Xia, YY (corresponding author), Lanzhou Univ, Clin Med Sch 2, Lanzhou 730030, Peoples R China.
EM 120220901491@lzu.edu.cn; chencs666@ynu.edu.cn; 120220901411@lzu.edu.cn;
   120220901481@lzu.edu.cn; liuzt2023@lzu.edu.cn; wenl2023@lzu.edu.cn;
   120220901471@lzu.edu.cn; ery_gengb@lzu.edu.cn; xiayy@lzu.edu.cn
RI uu, ii/KRQ-2411-2024
FU National Natural Science Foundation of China; Lanzhou Science and
   Technology Plan Program [2021-RC-102]; Natural Science Foundation of
   Gansu Province [22JR5RA943, 23JRRA1500, 22JR5RA956]; Cuiying Scientific
   and Technological Innovation Program of Lanzhou University Second
   Hospital [CY2021-MS-A07];  [82060405];  [82360436];  [81960403]
FX This research was funded by the National Natural Science Foundation of
   China (82060405 and 82360436 to Y.X. 81960403 to B.G.), the Lanzhou
   Science and Technology Plan Program (2021-RC-102 to Y.X.), the Natural
   Science Foundation of Gansu Province (22JR5RA943 and 23JRRA1500 to B.G.,
   22JR5RA956 to Y.X.), and the Cuiying Scientific and Technological
   Innovation Program of Lanzhou University Second Hospital (CY2021-MS-A07
   to B.G.).
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NR 169
TC 0
Z9 0
U1 0
U2 0
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2218-273X
J9 BIOMOLECULES
JI Biomolecules
PD MAY 8
PY 2025
VL 15
IS 5
AR 686
DI 10.3390/biom15050686
PG 27
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 3BZ2N
UT WOS:001496708500001
PM 40427579
DA 2025-06-11
ER

PT J
AU Gangadharan, C
   Ahluwalia, R
   Sigamani, A
AF Gangadharan, Charitha
   Ahluwalia, Rupa
   Sigamani, Alben
TI Diabetes and COVID-19: Role of insulin resistance as a risk factor for
   COVID-19 severity
SO WORLD JOURNAL OF DIABETES
LA English
DT Review
DE Insulin resistance; Renin-angiotensin system; Blood flow measurements;
   Inflammation; Thrombosis; Severity of COVID-19
ID RENIN-ANGIOTENSIN SYSTEM; CORONAVIRUS DISEASE 2019; ISLET BLOOD-FLOW;
   PANCREATIC-ISLET; NITRIC-OXIDE
AB Patients with diabetes are more susceptible to coronavirus disease 2019 (COVID-19), and as a consequence, develop more severe form of disease. This is partly due to a systemic inflammatory state and pro thrombotic milieu seen in metabolic syndrome. In this review, we attempt to explore the pathogenetic links between insulin resistance and COVID-19 disease severity. Insulin resistance is an underlying condition for metabolic syndromes, including type 2 diabetes, which impairs insulin signaling pathways affecting metabolic and cardiovascular homeostasis. A high concentration of circulating insulin shifts the balance to mitogen activated protein kinase (MAPK)-dependent signaling and causes endothelial cell damage. The phosphatidylinositol 3 kinase and MAPK dependent signaling pathways maintain a balance between nitric oxide-dependent vasodilator and endothelin-1 dependent vasoconstriction actions of insulin. Vascular smooth muscle cell dysfunction is responsible for inflammation and blood coagulation leading to microvascular and macrovascular complications in diabetes. Hyperactivity in renin-angiotensin system is implicated in development of islet oxidative stress and subsequent beta-cell dysfunction, as it alters the islet blood flow. These deleterious effects of insulin resistance involving altered blood pressure, vascular dysfunction, and inflammation could be associated with increased severity in COVID-19 patients. We conclude that clinical and/or biochemical markers of insulin resistance should be included as prognostic markers in assessment of acute COVID-19 disease.
C1 [Gangadharan, Charitha] Narayana Hrudayalaya Ltd, Dept Clin Res, Bangalore 560099, Karnataka, India.
   [Ahluwalia, Rupa] Norfolk & Norwich Univ Hosp NHS Fdn Trust, Diabet & Endocrinol, Norwich NR4 7UY, Norfolk, England.
   [Sigamani, Alben] Numen Hlth, 19,4th C Cross Koramangala Ind,5th Block,Area, Bangalore 560095, Karnataka, India.
C3 Norfolk & Norwich University Hospitals NHS Foundation Trust
RP Sigamani, A (corresponding author), Numen Hlth, 19,4th C Cross Koramangala Ind,5th Block,Area, Bangalore 560095, Karnataka, India.
EM dralbens@numenhealth.com
RI Sigamani, Alben/GQH-0406-2022
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NR 57
TC 23
Z9 25
U1 0
U2 4
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 7041 Koll Center Parkway, Suite 160, PLEASANTON, CA, UNITED STATES
EI 1948-9358
J9 WORLD J DIABETES
JI World J. Diabetes
PD SEP 15
PY 2021
VL 12
IS 9
BP 1550
EP 1562
DI 10.4239/wjd.v12.i9.1550
PG 13
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA WC8PC
UT WOS:000704513500013
PM 34630907
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Peres, BU
   Allen, AJH
   Fox, N
   Laher, I
   Hanly, P
   Skomro, R
   Almeida, F
   Ayas, NT
AF Peres, Bernardo U.
   Allen, A. J. Hirsch
   Fox, Nurit
   Laher, Ismail
   Hanly, Patrick
   Skomro, Robert
   Almeida, Fernanda
   Ayas, Najib T.
CA Canadian Sleep Circadian Network
TI Circulating biomarkers to identify cardiometabolic complications in
   patients with Obstructive Sleep Apnea: A systematic review
SO SLEEP MEDICINE REVIEWS
LA English
DT Review
DE Obstructive sleep apnea (OSA); Biomarkers; Adult; Systematic review
ID C-REACTIVE PROTEIN; POSITIVE AIRWAY PRESSURE; CARDIOVASCULAR RISK;
   OXIDATIVE STRESS; INTERMITTENT HYPOXIA; GLUCOSE-METABOLISM;
   PATHOPHYSIOLOGY; DISEASE; HEART
AB Untreated Obstructive sleep apnea (OSA) is associated with an increased risk of cardiometabolic diseases such as diabetes and myocardial infarction. However, it is difficult to predict which patients are at particularly high risk. This systematic review aimed to identify potentially useful circulating biomarkers that could predict cardiometabolic complications in OSA. We searched Cochrane (EBM), EMBASE, Medline, PubMed, and Web of Science databases. Search concepts included: "Obstructive Sleep Apnea", "Biomarkers" and "Risk-Stratification". Manuscripts were included if they studied adults with OSA, circulating (blood) markers, and relationships with clinical outcomes. After screening, 10 were included. Studies addressed cardiovascular disease, type 2 diabetes, end-stage renal disease and metabolic syndrome. In general, levels of inflammatory markers, adhesion molecules, and vascular proteins were associated with the presence of cardiometabolic disease in OSA patients. Although studies regarding prognostic circulating biomarkers in OSA are limited, a number of potentially promising biomarkers were identified in our review. However, more research is needed using prospective cohorts to determine which biomarkers are most robustly associated with and useful in predicting future cardiovascular and metabolic sequelae in OSA patients. Identification of such biomarkers could guide more selective and targeted therapy for OSA in an emerging era of precision-based medicine. (C) 2018 Elsevier Ltd. All rights reserved.
C1 [Peres, Bernardo U.; Almeida, Fernanda] Univ British Columbia, Dept Oral Hlth Sci, Fac Dent, Vancouver, BC, Canada.
   [Allen, A. J. Hirsch; Fox, Nurit; Ayas, Najib T.] Univ British Columbia, Dept Med, Fac Med, 2775 Laurel St,7th Floor, Vancouver, BC V5Z 1M9, Canada.
   [Hanly, Patrick] Univ Calgary, Cumming Sch Med, Dept Med, Calgary, AB, Canada.
   [Skomro, Robert] Univ Saskatchewan, Coll Med, Saskatoon, SK, Canada.
   [Skomro, Robert] Wroclaw Med Univ, Div Angiol, Pasteura 1 St, PL-50367 Wroclaw, Poland.
   [Laher, Ismail] Univ British Columbia, Fac Med, Dept Anesthesiol Pharmacol & Therapeut, Vancouver, BC, Canada.
C3 University of British Columbia; University of British Columbia;
   University of Calgary; University of Saskatchewan; Wroclaw Medical
   University; University of British Columbia
RP Ayas, NT (corresponding author), Univ British Columbia, Dept Med, Fac Med, 2775 Laurel St,7th Floor, Vancouver, BC V5Z 1M9, Canada.
EM NAyas@providencehealth.bc.ca
RI Almeida, Fernanda/KSM-1833-2024; Laher, Ismail/X-3323-2019
OI Hanly, Patrick/0000-0003-0689-1038; Laher, Ismail/0000-0002-3917-4417
FU Canadian Institutes of Health Research (CIHR)
FX Supported by the Canadian Institutes of Health Research (CIHR). The
   sponsor had no role in the design or conduct of this research.
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NR 48
TC 20
Z9 22
U1 0
U2 14
PU W B SAUNDERS CO LTD
PI LONDON
PA 32 JAMESTOWN RD, LONDON NW1 7BY, ENGLAND
SN 1087-0792
EI 1532-2955
J9 SLEEP MED REV
JI Sleep Med. Rev.
PD APR
PY 2019
VL 44
BP 48
EP 57
DI 10.1016/j.smrv.2018.12.004
PG 10
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA HM1ZD
UT WOS:000459253900005
PM 30685729
DA 2025-06-11
ER

PT J
AU Zhang, W
   Wu, MR
   Kim, T
   Jariwala, RH
   Garvey, WJ
   Luo, NL
   Kang, MS
   Ma, E
   Tian, L
   Steverson, D
   Yang, QL
   Fu, YC
   Garvey, WT
AF Zhang, Wei
   Wu, Mengrui
   Kim, Teayoun
   Jariwala, Ravi H.
   Garvey, W. John
   Luo, Nanlan
   Kang, Minsung
   Ma, Elizabeth
   Tian, Ling
   Steverson, Dennis
   Yang, Qinglin
   Fu, Yuchang
   Garvey, W. Timothy
TI Skeletal Muscle TRIB3 Mediates Glucose Toxicity in Diabetes and High-Fat
   Diet-Induced Insulin Resistance
SO DIABETES
LA English
DT Article
ID GLUTAMINE-FRUCTOSE-6-PHOSPHATE AMIDOTRANSFERASE; TRIBBLES HOMOLOG;
   TRANSPORT SYSTEM; HEXOSAMINE BIOSYNTHESIS; INDUCED DESENSITIZATION;
   BIOCHEMICAL PATHWAYS; GLUT4 TRANSLOCATION; METABOLIC SYNDROME;
   TRANSGENIC MICE; TRB3
AB In the current study, we used muscle-specific TRIB3 over-expressing (MOE) and knockout (MKO) mice to determine whether TRIB3 mediates glucose-induced insulin resistance in diabetes and whether alterations in TRIB3 expression as a function of nutrient availability have a regulatory role in metabolism. In streptozotocin diabetic mice, TRIB3 MOE exacerbated, whereas MKO prevented, glucose-induced insulin resistance and impaired glucose oxidation and defects in insulin signal transduction compared with wild-type (WT) mice, indicating that glucose-induced insulin resistance was dependent on TRIB3. In response to a high-fat diet, TRIB3 MOE mice exhibited greater weight gain and worse insulin resistance in vivo compared with WT mice, coupled with decreased AKT phosphorylation, increased inflammation and oxidative stress, and upregulation of lipid metabolic genes coupled with downregulation of glucose metabolic genes in skeletal muscle. These effects were prevented in the TRIB3 MKO mice relative to WT mice. In conclusion, TRIB3 has a pathophysiological role in diabetes and a physiological role in metabolism. Glucose-induced insulin resistance and insulin resistance due to diet-induced obesity both depend on muscle TRIB3. Under physiological conditions, muscle TRIB3 also influences energy expenditure and substrate metabolism, indicating that the decrease and increase in muscle TRIB3 under fasting and nutrient excess, respectively, are critical for metabolic homeostasis.
C1 [Zhang, Wei; Jariwala, Ravi H.; Garvey, W. John; Luo, Nanlan; Kang, Minsung; Ma, Elizabeth; Tian, Ling; Steverson, Dennis; Yang, Qinglin; Fu, Yuchang; Garvey, W. Timothy] Univ Alabama Birmingham, Dept Nutr Sci, Birmingham, AL 35294 USA.
   [Wu, Mengrui] Univ Alabama Birmingham, Dept Mol & Cellular Pathol, Birmingham, AL USA.
   [Kim, Teayoun] Univ Alabama Birmingham, Dept Med Endocrinol Diabet & Metab, Birmingham, AL USA.
   [Garvey, W. Timothy] Birmingham Vet Affairs Med Ctr, Birmingham, AL 35233 USA.
C3 University of Alabama System; University of Alabama Birmingham;
   University of Alabama System; University of Alabama Birmingham;
   University of Alabama System; University of Alabama Birmingham; US
   Department of Veterans Affairs; Veterans Health Administration (VHA);
   Veterans Affairs Medical Center - Birmingham
RP Zhang, W; Garvey, WT (corresponding author), Univ Alabama Birmingham, Dept Nutr Sci, Birmingham, AL 35294 USA.; Garvey, WT (corresponding author), Birmingham Vet Affairs Med Ctr, Birmingham, AL 35233 USA.
EM siweizh@uab.edu; garveyt@uab.edu
RI Garvey, W. Timothy/KVX-9404-2024; Zhang, Wei/K-9379-2014
OI Zhang, Wei/0000-0001-7923-8107; Kang, Misnung/0009-0002-3672-3174; Kim,
   Teayoun/0000-0003-4664-6803
FU National Institutes of Health [DK-038765, DK-083562]; Department of
   Veterans Affairs Merit Review Program; American Diabetes Association
   [1-13-IN-19]; National Institute of Diabetes and Digestive and Kidney
   Diseases [P60 DK079626]
FX This work was supported by grants from the National Institutes of Health
   (DK-038765 and DK-083562), the Department of Veterans Affairs Merit
   Review Program, and the American Diabetes Association (1-13-IN-19) and
   by a grant from the National Institute of Diabetes and Digestive and
   Kidney Diseases to the UAB Diabetes Research Center Core Facilities (P60
   DK079626).
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NR 44
TC 36
Z9 45
U1 0
U2 11
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0012-1797
EI 1939-327X
J9 DIABETES
JI Diabetes
PD AUG
PY 2016
VL 65
IS 8
BP 2380
EP 2391
DI 10.2337/db16-0154
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA DS4KQ
UT WOS:000380750400031
PM 27207527
OA Green Published
DA 2025-06-11
ER

PT J
AU Kim, KM
   Lee, KS
   Lee, GY
   Jin, H
   Durrance, ES
   Park, HS
   Choi, SH
   Park, KS
   Kim, YB
   Jang, HC
   Lim, S
AF Kim, Kyoung Min
   Lee, Kuy-Sook
   Lee, Gha Young
   Jin, Hyunjin
   Durrance, Eunice Sung
   Park, Ho Seon
   Choi, Sung Hee
   Park, Kyong Soo
   Kim, Young-Bum
   Jang, Hak Chul
   Lim, Soo
TI Anti-diabetic efficacy of KICG1338, a novel glycogen synthase kinase-3β
   inhibitor, and its molecular characterization in animal models of type 2
   diabetes and insulin resistance
SO MOLECULAR AND CELLULAR ENDOCRINOLOGY
LA English
DT Article
DE Glycogen synthase kinase-3; Obesity; Diabetes; OLETF rat; Diet-induced
   obese mice; GLUT
ID RECEPTOR SUBSTRATE 1; KAPPA-B ACTIVATION; KINASE 3-BETA; IN-VIVO;
   SKELETAL-MUSCLE; PROTEIN-KINASE; GLUCOSE-INTOLERANCE; METABOLIC
   SYNDROME; C57BL/6J MICE; UP-REGULATION
AB Selective inhibition of glycogen synthase kinase-3 (GSK3) has been targeted as a novel therapeutic strategy for diabetes mellitus. We investigated the anti-diabetic efficacy and molecular mechanisms of KICG1338 (2-(4-fluoro-phenyl)-3H-imidazo[4,5-b]pyridine-7-carboxylic acid(4-methyl-pyridin-3-yl)-amide), a GSK3 beta inhibitor, in three animal models: Otsuka Long-Evans Tokushima Fatty (OLETF) rats, leptin receptors-deficient db/db mice, and diet-induced obese (DIO) mice. Biochemical parameters including glucose tolerance tests and gene expressions associated with glucose metabolism were investigated. Glucose excursion decreased significantly by KICG1338-treated OLETF rats, accompanied by increase in insulin receptor substrate-1 and glucose transporter (GLUT)-4 expressions in muscle and decreased GLUT-2 expression in liver. Glucose-lowering effects were similarly observed in KICG1338-treated db/db and DIO mice. KICG1338 treatment increased adiponectin levels and decreased TNF-alpha levels. KICG1338 therapy also led to greater beta-cell preservation and less hepatic fat infiltration with decreased expressions of genes involved in inflammation and endoplasmic reticulum stress. These data demonstrate anti-diabetic efficacy of KICG1338, a novel GSK3 beta inhibitor. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
C1 [Kim, Kyoung Min; Lee, Kuy-Sook; Lee, Gha Young; Jin, Hyunjin; Durrance, Eunice Sung; Choi, Sung Hee; Jang, Hak Chul; Lim, Soo] Seoul Natl Univ, Bundang Hosp, Coll Med, Dept Internal Med, Songnam 463707, South Korea.
   [Lee, Kuy-Sook; Lee, Gha Young; Jin, Hyunjin; Durrance, Eunice Sung] Seoul Natl Univ, Bundang Hosp, Biomed Res Inst, Songnam 463707, South Korea.
   [Park, Ho Seon; Park, Kyong Soo] Seoul Natl Univ, Coll Med, Dept Internal Med, Seoul, South Korea.
   [Park, Kyong Soo; Kim, Young-Bum] Seoul Natl Univ, Coll Med, Grad Sch Convergence Sci & Technol, Dept Mol Med & Biopharmaceut Sci, Seoul, South Korea.
   [Kim, Young-Bum] Beth Israel Deaconess Med Ctr, Div Endocrinol Metab & Diabet, Boston, MA 02215 USA.
   [Kim, Young-Bum] Harvard Univ, Sch Med, Boston, MA USA.
C3 Seoul National University (SNU); Seoul National University (SNU); Seoul
   National University (SNU); Seoul National University (SNU); Harvard
   University; Harvard University Medical Affiliates; Beth Israel Deaconess
   Medical Center; Harvard University; Harvard Medical School
RP Lim, S (corresponding author), Seoul Natl Univ, Bundang Hosp, Coll Med, Dept Internal Med, 300 Gumi Dong, Songnam 463707, South Korea.
EM limsoo@snu.ac.kr
RI Choi, Sung-hee/J-5689-2012; Kim, Kyung/N-6095-2017; Lim,
   Soo/AAU-8107-2020; Jang, Hak/D-9637-2012; Park, Kyong Soo/C-2265-2008
OI Kim, Kyoung Min/0000-0001-8150-0266; Park, Kyong
   Soo/0000-0003-3597-342X; Park, Ho Seon/0000-0003-1200-4626; Lim,
   Soo/0000-0002-4137-1671; CHOI, SUNG HEE/0000-0003-0740-8116
FU Industry-Academic Cooperation Foundation of Gyeonggi-province; Yuyu
   pharmaceutical company [06-2008-095]
FX This study was supported by a grant of Industry-Academic Cooperation
   Foundation of Gyeonggi-province through a subcontract with Yuyu
   pharmaceutical company (06-2008-095). The funding agency had no role in
   the study design, data collection and analysis, decision to publish, or
   preparation of the manuscript. The sole responsibility for the content
   of this paper lies with the authors.
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NR 49
TC 39
Z9 44
U1 0
U2 37
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0303-7207
J9 MOL CELL ENDOCRINOL
JI Mol. Cell. Endocrinol.
PD JUL 5
PY 2015
VL 409
IS C
BP 1
EP 10
DI 10.1016/j.mce.2015.03.011
PG 10
WC Cell Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Endocrinology & Metabolism
GA CI8QH
UT WOS:000355036300001
PM 25802191
DA 2025-06-11
ER

PT J
AU Chung, JO
   Cho, DH
   Chung, DJ
   Chung, MY
AF Chung, Jin Ook
   Cho, Dong Hyeok
   Chung, Dong Jin
   Chung, Min Young
TI The Duration of Diabetes is Inversely Associated with the Physiological
   Serum Bilirubin Levels in Patients with Type 2 Diabetes
SO INTERNAL MEDICINE
LA English
DT Article
DE bilirubin; type 2 diabetes mellitus
ID LOW-DENSITY-LIPOPROTEIN; OXIDATIVE STRESS; METABOLIC SYNDROME; DISEASE;
   ANEMIA; RISK
AB Objective The aim of this study was to assess the relationship between the duration of diabetes and the physiological serum bilirubin concentration in association with antioxidant properties in patients with type 2 diabetes.
   Methods A total of 1,746 patients with type 2 diabetes were investigated in this cross-sectional study. An analysis of covariance was performed after adjusting for other covariates. Simple correlation analyses and a multivariate regression model were used to assess the association between the duration of diabetes and the serum bilirubin concentration.
   Results The mean total bilirubin value differed significantly according to the tertile of diabetes duration (<5 years, 12.38 mu mol/L, 95% confidence interval (CI) 12.02-12.76; 5-11.9 years, 12.33 mu mol/L, 95% CI 11.97-12.69; >= 12 years, 11.73 mu mol/L, 95% CI 11.35-12.11; p for trend=0.033), after adjustment for other covariates. In addition, an inverse correlation was found between the serum bilirubin concentration and diabetes duration (rho=-0.211, p<0.001). According to a multivariate model, the association between the diabetes duration and serum bilirubin concentration remained significant, even after adjustment for confounding factors (beta=-0.074, p=0.008).
   Conclusion The duration of diabetes is inversely associated with a serum bilirubin concentration within the physiologic range in patients with type 2 diabetes.
C1 [Chung, Jin Ook; Cho, Dong Hyeok; Chung, Dong Jin; Chung, Min Young] Chonnam Natl Univ, Dept Internal Med, Sch Med, Kwangju, South Korea.
C3 Chonnam National University
RP Chung, MY (corresponding author), Chonnam Natl Univ, Dept Internal Med, Sch Med, Kwangju, South Korea.
EM mychung@chonnam.ac.kr
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NR 32
TC 9
Z9 13
U1 0
U2 7
PU JAPAN SOC INTERNAL MEDICINE
PI TOKYO
PA 34-3 3-CHOME HONGO BUNKYO-KU, TOKYO, 113, JAPAN
SN 0918-2918
EI 1349-7235
J9 INTERNAL MED
JI Intern. Med.
PY 2015
VL 54
IS 2
BP 141
EP 146
DI 10.2169/internalmedicine.54.2858
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA AZ3MO
UT WOS:000348131900007
PM 25743004
OA gold
DA 2025-06-11
ER

PT J
AU Toda, N
   Okamura, T
AF Toda, Noboru
   Okamura, Tomio
TI Obesity Impairs Vasodilatation and Blood Flow Increase Mediated by
   Endothelial Nitric Oxide: An Overview
SO JOURNAL OF CLINICAL PHARMACOLOGY
LA English
DT Review
DE obesity; endothelium-dependent vasodilatation; nitric oxide; adipokine;
   pharmacological treatment
ID DIET-INDUCED OBESITY; PERIVASCULAR ADIPOSE-TISSUE; FAT-DIET;
   WEIGHT-LOSS; DEPENDENT VASODILATION; METABOLIC-SYNDROME; OXIDATIVE
   STRESS; INSULIN-RESISTANCE; VASCULAR FUNCTION; CARDIOVASCULAR RISK
AB Obesity dramatically increases the risk of development of cardiovascular and metabolic diseases. Endothelial dysfunction induced by obesity is an important risk factor that impairs blood flow controls in various organs. Impaired endothelial function occurs early in life in obese children. Obesity-induced endothelial dysfunction is associated with decreased nitric oxide (NO) production due to impaired endothelial NO synthase activity and expression and increased production of superoxide anion and the endogenous NOS inhibitor ADMA, together with increased vasoconstrictor factors, such as endothelin-1 and sympathetic nerve activation. Decreased endothelial progenitor cells are also involved in endothelial cell senescence in obese individuals. Insulin resistance and diabetes mellitus augment obesity-induced endothelial dysfunction. Adipokines liberated from adipose tissues play roles in modulating endothelial function; adiponectin and ghrelin have beneficial effects on endothelial cells. Effects of leptin on endothelial function are controversial. Decreased body weight by physical exercise, dietary interventions, and bariatric surgery are effective measures that reverse endothelial dysfunction; however, the weight control is not only the reason for improving of endothelia function. Pharmacological therapies with -adrenoceptor antagonists, resveratolol, anti-obesity agents, nifedipine, and NADPH oxidase inhibitors may also be effective; however, these treatments have to be utilized under the basis of exercise and dietary controls.
C1 [Toda, Noboru] Toyama Inst Cardiovasc Pharmacol Res, Chuo Ku, Osaka 5410052, Japan.
   [Toda, Noboru; Okamura, Tomio] Shiga Univ Med Sci, Dept Pharmacol, Shiga, Japan.
C3 Shiga University of Medical Science
RP Toda, N (corresponding author), Toyama Inst Cardiovasc Pharmacol Res, Chuo Ku, 7-13 1-Chome, Osaka 5410052, Japan.
EM n.toda.toyama-bldg@orion.ocn.ne.jp
FU Ministry of Education, Culture, Sports, Science and Technology of Japan
   [23390055]; Grants-in-Aid for Scientific Research [23390055] Funding
   Source: KAKEN
FX This work was supported in part by grants-in-aid for scientific research
   from the Ministry of Education, Culture, Sports, Science and Technology
   of Japan (23390055).
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NR 115
TC 63
Z9 68
U1 0
U2 32
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0091-2700
EI 1552-4604
J9 J CLIN PHARMACOL
JI J. Clin. Pharmacol.
PD DEC
PY 2013
VL 53
IS 12
BP 1228
EP 1239
DI 10.1002/jcph.179
PG 12
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 252OB
UT WOS:000327015000002
PM 24030923
DA 2025-06-11
ER

PT J
AU van de Woestijne, AP
   Monajemi, H
   Kalkhoven, E
   Visseren, FLJ
AF van de Woestijne, A. P.
   Monajemi, H.
   Kalkhoven, E.
   Visseren, F. L. J.
TI Adipose tissue dysfunction and hypertriglyceridemia: mechanisms and
   management
SO OBESITY REVIEWS
LA English
DT Article
DE Adipose tissue; atherosclerosis; obesity; triglycerides
ID TUMOR-NECROSIS-FACTOR; ENDOPLASMIC-RETICULUM STRESS;
   CORONARY-HEART-DISEASE; FREE FATTY-ACIDS; INSULIN-RESISTANCE;
   LIPOPROTEIN-LIPASE; METABOLIC SYNDROME; BLOOD-FLOW; NONFASTING
   TRIGLYCERIDES; CARDIOVASCULAR-DISEASE
AB Elevated plasma triglyceride levels, as often seen in obese subjects, are independently associated with an increased risk of cardiovascular diseases. By secreting adipokines (such as adiponectin and leptin) and other proteins (such as lipoprotein lipase and cholesteryl ester transferase protein), adipose tissue affects triglyceride metabolism. In obesity, adipocyte hypertrophy leads to many changes in adipocyte function and production of anti-and pro-inflammatory cytokines. Furthermore, free fatty acids are released into the circulation contributing to insulin resistance. Adipose tissue dysfunction will eventually lead to abnormalities in lipid metabolism, such as hypertriglyceridemia (due to increased hepatic very-low-density lipoprotein production and decreased triglyceride hydrolysis), small dense low-density lipoprotein particles, remnant lipoproteins and low high-density lipoprotein cholesterol levels, all associated with a higher risk for the development of cardiovascular diseases. The clinical implications of elevated plasma triglycerides are still a matter of debate. Understanding the pathophysiology of adipose tissue dysfunction in obesity, which is becoming a pandemic condition, is essential for designing appropriate therapeutic interventions. Lifestyle changes are important to improve adipose tissue function in obese patients. Pharmacological interventions to improve adipose tissue function need further evaluation. Although statins are not very potent in reducing plasma triglycerides, they remain the mainstay of therapy for cardiovascular risk reduction in high-risk patients.
C1 [van de Woestijne, A. P.; Monajemi, H.; Visseren, F. L. J.] Univ Med Ctr Utrecht, Dept Vasc Med, NL-3508 GA Utrecht, Netherlands.
   [Kalkhoven, E.] Univ Med Ctr, Dept Metab & Endocrine Dis, Utrecht, Netherlands.
   [Kalkhoven, E.] Univ Med Ctr, Dept Pediat Immunol, Utrecht, Netherlands.
   [Kalkhoven, E.] Netherlands Metabol Ctr, Leiden, Netherlands.
C3 Utrecht University; Utrecht University Medical Center; Utrecht
   University; Utrecht University Medical Center; Utrecht University;
   Utrecht University Medical Center
RP Visseren, FLJ (corresponding author), Univ Med Ctr Utrecht, Dept Vasc Med, POB 85500, NL-3508 GA Utrecht, Netherlands.
EM f.l.j.visseren@umcutrecht.nl
RI Visseren, Frank/I-4855-2013
OI Visseren, Frank/0000-0003-3951-5223
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NR 101
TC 76
Z9 86
U1 0
U2 13
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1467-7881
EI 1467-789X
J9 OBES REV
JI Obes. Rev.
PD OCT
PY 2011
VL 12
IS 10
BP 829
EP 840
DI 10.1111/j.1467-789X.2011.00900.x
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 823QV
UT WOS:000295139400006
PM 21749607
DA 2025-06-11
ER

PT J
AU Kim, S
   Kim, S
   Hong, KH
AF Kim, Sohye
   Kim, Soojeong
   Hong, Kyung Hee
TI Association of Combining Diet and Physical Activity on Sarcopenia and
   Obesity in Elderly Koreans with Diabetes
SO NUTRIENTS
LA English
DT Article
DE dietary factor; diabetic elderly; KNHANES; obesity; physical activity;
   sarcopenia
ID NATIONAL-HEALTH; METABOLIC SYNDROME; RISK
AB This study aimed to identify the combined factors of physical activity and diet associated with non-sarcopenic non-obese status in 1586 diabetic patients aged >= 65 years from the Korean National Health and Nutrition Examination Survey (2016 to 2019). Participants were categorized into non-sarcopenic non-obesity (NSNO), sarcopenia non-obesity (SNO), non-sarcopenic obesity (NSO), and sarcopenic obesity (SO) groups. NSNO had lower insulin, HOMA-IR, and triglycerides compared to NSO and SO. NSNO had lower perceived stress, higher nutrition education and dietary supplement intake. As assessed by the Korean Healthy Eating Index, NSNO scored higher total than SNO and SO, in breakfast and energy balance compared to SO, and in the adequacy of vegetables and meat/fish/egg/bean compared to SNO. NSNO had significantly higher energy and protein intake and physical activity, with BMI/waist circumference lower than NSO, SO, and comparable to SNO. Physical activity was positively associated with NSNO. Low Total KHEI score and protein intake level reduced the odds ratio (OR) of NSNO, particularly when physical activity was insufficient, with OR = 0.38 for KHEI Q1 and OR = 0.32 for protein T1. In conclusion, physical activity, diet quality, and protein intake are associated with NSNO prevalence in Korean elderly with diabetes, and energy balance through active intake and expenditure may be effective.
C1 [Kim, Sohye] Seoul Natl Univ, Bundang Hosp, Nutr Care Serv, Seongnam 13620, South Korea.
   [Kim, Soojeong] Dongseo Univ, Dept Hlth Adm, Busan 47011, South Korea.
   [Hong, Kyung Hee] Dongseo Univ, Dept Food Sci & Nutr, Busan 47011, South Korea.
C3 Seoul National University (SNU); Dongseo University; Dongseo University
RP Hong, KH (corresponding author), Dongseo Univ, Dept Food Sci & Nutr, Busan 47011, South Korea.
EM sohye76@daum.net; sjkim@dongseo.ac.kr; hkhee@gdsu.dongseo.ac.kr
RI Kim, Hyo/AAQ-3152-2020; Kim, Seong Cheol/ABD-1493-2022
OI Hong, Kyung Hee/0000-0003-4956-8177; Kim, Sohye/0000-0003-0880-3580
FU Dongseo University Research Fund of 2022
FX This work was supported by Dongseo University Research Fund of 2022.
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NR 42
TC 4
Z9 4
U1 4
U2 6
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD APR
PY 2024
VL 16
IS 7
AR 964
DI 10.3390/nu16070964
PG 16
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA NM4F6
UT WOS:001200850100001
PM 38612998
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Tsuji, M
   Tanaka, N
   Koike, H
   Sato, Y
   Shimoyama, Y
   Itoh, A
AF Tsuji, Masahiro
   Tanaka, Nao
   Koike, Hitomi
   Sato, Yoshiaki
   Shimoyama, Yoshie
   Itoh, Ayaka
TI Various Organ Damages in Rats with Fetal Growth Restriction and Their
   Slight Attenuation by Bifidobacterium breve Supplementation
SO LIFE-BASEL
LA English
DT Article
DE probiotics; Bifidobacterium breve; fetal growth restriction; low
   birthweight; kidneys; small intestine; skeletal muscles
ID POOR MATERNAL NUTRITION; INTRAUTERINE GROWTH; PLACENTAL INSUFFICIENCY;
   INTESTINAL MICROBIOTA; OXIDATIVE STRESS; SKELETAL-MUSCLE; NEPHRON
   NUMBER; BIRTH-WEIGHT; RETARDATION; MODEL
AB Children with fetal growth restriction (FGR) and its resultant low birthweight (LBW) are at a higher risk of developing various health problems later in life, including renal diseases, metabolic syndrome, and sarcopenia. The mechanism through which LBW caused by intrauterine hypoperfusion leads to these health problems has not been properly investigated. Oral supplementation with probiotics is expected to reduce these risks in children. In the present study, rat pups born with FGR-LBW after mild intrauterine hypoperfusion were supplemented with either Bifidobacterium breve (B. breve) or a vehicle from postnatal day 1 (P1) to P21. Splanchnic organs and skeletal muscles were evaluated at six weeks of age. Compared with the sham group, the LBW-vehicle group presented significant changes as follows: overgrowth from infancy to childhood; lighter weight of the liver, kidneys, and gastrocnemius and plantaris muscles; reduced height of villi in the ileum; and increased depth of crypts in the jejunum. Some of these changes were milder in the LBW-B.breve group. In conclusion, this rat model could be useful for investigating the mechanisms of how FGR-LBW leads to future health problems and for developing interventions for these problems. Supplementation with B. breve in early life may modestly attenuate these problems.
C1 [Tsuji, Masahiro; Tanaka, Nao; Koike, Hitomi; Itoh, Ayaka] Kyoto Womens Univ, Dept Food & Nutr, Kyoto 6058501, Japan.
   [Sato, Yoshiaki] Nagoya Univ Hosp, Ctr Maternal Neonatal Care, Div Neonatol, Nagoya 4668560, Japan.
   [Shimoyama, Yoshie] Nagoya Univ Hosp, Dept Pathol, Nagoya 4668560, Japan.
C3 Kyoto Womens University; Nagoya University; Nagoya University
RP Tsuji, M (corresponding author), Kyoto Womens Univ, Dept Food & Nutr, Kyoto 6058501, Japan.
EM tsujima@kyoto-wu.ac.jp; yoshiaki@med.nagoya-u.ac.jp
RI Sato, Yoshiaki/I-7414-2014; Tsuji, Masahiro/J-1201-2019; SHIMOYAMA,
   Yoshie/I-7361-2014
OI Tsuji, Masahiro/0000-0002-1540-3641; Sato, Yoshiaki/0000-0001-6320-9176
FU The authors thank Ritsuko Maki for their technical assistance.;
   Grants-in-Aid for Scientific Research [21K07794] Funding Source: KAKEN
FX The authors thank Ritsuko Maki for their technical assistance.
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NR 50
TC 0
Z9 0
U1 0
U2 0
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2075-1729
J9 LIFE-BASEL
JI Life-Basel
PD OCT
PY 2023
VL 13
IS 10
AR 2005
DI 10.3390/life13102005
PG 11
WC Biology; Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics; Microbiology
GA X4FD1
UT WOS:001098017600001
PM 37895387
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Quiroz-Aldave, J
   Durand-Vasquez, M
   Gamarra-Osorio, E
   -Rojas, JS
   Roseboom, PJ
   Alcala-Mendoza, R
   Coronado-Arroyo, J
   Zavaleta-Gutierrez, F
   Concepcion-Urteaga, L
   Zavaleta, MC
AF Quiroz-Aldave, Juan
   Durand-Vasquez, Maria
   Gamarra-Osorio, Elman
   -Rojas, Jacsel Suarez
   Roseboom, Pela Jantine
   Alcala-Mendoza, Rosa
   Coronado-Arroyo, Julia
   Zavaleta-Gutierrez, Francisca
   Concepcion-Urteaga, Luis
   Zavaleta, Marcio Concepcion-
TI Diabetic neuropathy: Past, present, and future
SO CASPIAN JOURNAL OF INTERNAL MEDICINE
LA English
DT Review
DE Diabetic Neuropathy; Diabetes Mellitus; Complication; Treatment;
   Glycemic Control; HbA1c
ID ALPHA-LIPOIC ACID; SPINAL-CORD STIMULATION; PERIPHERAL NEUROPATHY;
   RISK-FACTORS; DOUBLE-BLIND; SENSORY NEUROPATHY; METABOLIC SYNDROME;
   DIAGNOSTIC-CRITERIA; GROWTH-FACTOR; CELL-DEATH
AB Background: A sedentary lifestyle and an unhealthy diet have considerably increased the incidence of diabetes mellitus worldwide in recent decades, which has generated a high rate of associated chronic complications.Methods: A narrative review was performed in MEDLINE, EMBASES and SciELO databases, including 162 articles.Results: Diabetic neuropathy (DN) is the most common of these complications, mainly producing two types of involvement: sensorimotor neuropathy, whose most common form is symmetric distal polyneuropathy, and autonomic neuropathies, affecting the cardiovascular, gastrointestinal, and urogenital system. Although hyperglycemia is the main metabolic alteration involved in its genesis, the presents of obesity, dyslipidemia, arterial hypertension, and smoking, play an additional role in its appearance. In the pathophysiology, three main phenomena stand out: oxidative stress, the formation of advanced glycosylation end-products, and microvasculature damage. Diagnosis is clinical, and it is recommended to use a 10 g monofilament and a 128 Hz tuning fork as screening tools. Glycemic control and non-pharmacological interventions constitute the mainstay of DN treatment, although there are currently investigations in antioxidant therapies, in addition to pain management.Conclusions: Diabetes mellitus causes damage to peripheral nerves, being the most common form of this, distal symmetric polyneuropathy. Control of glycemia and comorbidities contribute to prevent, postpone, and reduce its severity. Pharmacological interventions are intended to relieve pain.
C1 [Durand-Vasquez, Maria] Hosp Apoyo Chepen, Div Med, Chepen, Peru.
   [Gamarra-Osorio, Elman] Hosp Apoyo Chepen, Div Family Med, Chepen, Peru.
   [-Rojas, Jacsel Suarez] Hosp Victor Lazarte Echegaray, Div Endocrinol, Trujillo, Peru.
   [Roseboom, Pela Jantine] Univ Cient, Lima, Peru.
   [Alcala-Mendoza, Rosa] Hosp Reg Docente Trujillo, Div Emergency Med, Trujillo, Peru.
   [Coronado-Arroyo, Julia] Hosp Victor Lazarte Echegaray, Div Phys Med & Rehabil, Trujillo, Peru.
   [Zavaleta-Gutierrez, Francisca] Hosp Nacl Edgardo Rebagliati Martins, Div Obstet & Gynecol, Lima, Peru.
   [Concepcion-Urteaga, Luis] Hosp Belen Trujillo, Div Neonatol, Trujillo, Peru.
   [Zavaleta, Marcio Concepcion-] Univ Nacl Trujillo, Sch Med, Trujillo, Peru.
   [Zavaleta, Marcio Concepcion-] Hosp Jorge Voto Bernales, Div Endocrinol, Lima, Peru.
C3 Universidad Cientifica del Sur (CIENTIFICA); Seguro Social de Salud del
   Peru; Universidad Nacional de Trujillo
RP Zavaleta, MC (corresponding author), Hosp Jorge Voto Bernales, Div Endocrinol, Lima, Peru.
EM marcio.concepcion@unmsm.edu.pe
RI Coronado-Arroyo, Julia/AAU-4658-2021; Concepción-Zavaleta,
   Marcio/AAI-2756-2021; Quiroz Aldave, Juan Eduardo/HGC-4769-2022
OI Durand Vasquez, Maria del Carmen Andaluces/0000-0001-7862-9333; Quiroz
   Aldave, Juan Eduardo/0000-0001-8286-095X; GAMARRA OSORIO, ELMAN
   ROLANDO/0000-0003-3707-5340; Concepcion Zavaleta, Marcio
   Jose/0000-0001-9719-1875
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NR 161
TC 10
Z9 10
U1 0
U2 5
PU BABOL UNIV MEDICAL SCIENCES
PI BABOL
PA ENGLISH JOURNAL OFFICE, GANJ AFROOZ AVE, BABOL, 00000, IRAN
SN 2008-6164
EI 2008-6172
J9 CASP J INTERN MED
JI Casp. J. Intern. Med.
PY 2023
VL 14
IS 2
BP 153
EP 169
DI 10.22088/cjim.14.2.153
PG 17
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA H3FN9
UT WOS:000994859200001
PM 37223297
DA 2025-06-11
ER

PT J
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   Garay, J
   Ramalingam, L
AF Shrestha, Akriti
   Prowak, Madison
   Berlandi-Short, Victoria-Marie
   Garay, Jessica
   Ramalingam, Latha
TI Maternal Obesity: A Focus on Maternal Interventions to Improve Health of
   Offspring
SO FRONTIERS IN CARDIOVASCULAR MEDICINE
LA English
DT Review
DE maternal obesity; nutritional interventions; physical activity; high fat
   diet; animal models
ID GESTATIONAL DIABETES-MELLITUS; HEART-RATE-VARIABILITY;
   PHYSICAL-ACTIVITY; WEIGHT-GAIN; RESISTANCE EXERCISE; INSULIN
   SENSITIVITY; METABOLIC SYNDROME; OXIDATIVE STRESS; AMERICAN-COLLEGE;
   BLOOD-PRESSURE
AB Maternal obesity has many implications for offspring health that persist throughout their lifespan that include obesity and cardiovascular complications. Several different factors contribute to obesity and they encompass interplay between genetics and environment. In the prenatal period, untreated obesity establishes a foundation for a myriad of symptoms and negative delivery experiences, including gestational hypertensive disorders, gestational diabetes, macrosomia, and labor complications. However, data across human and animal studies show promise that nutritional interventions and physical activity may rescue much of the adverse effects of obesity on offspring metabolic health. Further, these maternal interventions improve the health of the offspring by reducing weight gain, cardiovascular disorders, and improving glucose tolerance. Mechanisms from animal studies have also been proposed to elucidate the signaling pathways that regulate inflammation, lipid metabolism, and oxidative capacity of the tissue, ultimately providing potential specific courses of treatment. This review aims to pinpoint the risks of maternal obesity and provide plausible intervention strategies. We delve into recent research involving both animal and human studies with maternal interventions. With the increasing concerning of obesity rates witnessed in the United States, it is imperative to acknowledge the long-term effects posed on future generations and specifically modify maternal nutrition and care to mitigate these adverse outcomes.
C1 [Shrestha, Akriti; Prowak, Madison; Berlandi-Short, Victoria-Marie; Garay, Jessica; Ramalingam, Latha] Syracuse Univ, Dept Nutr & Food Studies, Syracuse, NY 13201 USA.
C3 Syracuse University
RP Ramalingam, L (corresponding author), Syracuse Univ, Dept Nutr & Food Studies, Syracuse, NY 13201 USA.
EM lramalin@syr.edu
RI Ramalingam, Latha/M-8438-2015
OI Garay, Jessica/0000-0001-8162-7742; Ramalingam,
   Latha/0000-0002-4856-7327
FU David B. Falk College of Sport and Human Dynamics and innovative and
   interdisciplinary Cuse Grant, Syracuse University
FX Funding was provided by David B. Falk College of Sport and Human
   Dynamics and innovative and interdisciplinary Cuse Grant, Syracuse
   University.
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NR 150
TC 28
Z9 29
U1 1
U2 17
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2297-055X
J9 FRONT CARDIOVASC MED
JI Front. Cardiovasc. Med.
PD JUL 21
PY 2021
VL 8
AR 696812
DI 10.3389/fcvm.2021.696812
PG 18
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Cardiovascular System & Cardiology
GA TU5AF
UT WOS:000681048400001
PM 34368253
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Calcaterra, V
   Verduci, E
   Cena, H
   Magenes, VC
   Todisco, CF
   Tenuta, E
   Gregorio, C
   De Giuseppe, R
   Bosetti, A
   Di Profio, E
   Zuccotti, G
AF Calcaterra, Valeria
   Verduci, Elvira
   Cena, Hellas
   Magenes, Vittoria Carlotta
   Todisco, Carolina Federica
   Tenuta, Elisavietta
   Gregorio, Cristina
   De Giuseppe, Rachele
   Bosetti, Alessandra
   Di Profio, Elisabetta
   Zuccotti, Gianvincenzo
TI Polycystic Ovary Syndrome in Insulin-Resistant Adolescents with Obesity:
   The Role of Nutrition Therapy and Food Supplements as a Strategy to
   Protect Fertility
SO NUTRIENTS
LA English
DT Review
DE polycystic ovary syndrome; fertility; obesity; adolescents; nutrition;
   diet; food supplements
ID ANTI-MULLERIAN HORMONE; D-CHIRO-INOSITOL; TYPE-2 DIABETES-MELLITUS;
   INDUCED OXIDATIVE STRESS; FATTY LIVER-DISEASE; IPOMOEA-BATATAS L.; RED
   YEAST RICE; SKELETAL-MUSCLE; METABOLIC SYNDROME; SECOISOLARICIRESINOL
   DIGLUCOSIDE
AB Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in young reproductive-aged women. PCOS is often associated with obesity and impairs reproductive health. Even though several theories have been proposed to explain the pathogenic mechanism of PCOS, the role of insulin resistance (IR) as a key etiological component, independently of (but amplified by) obesity, is well recognized. The consequent hyperinsulinemia activates excessive ovarian androgen production, leading to PCOS. Additionally, the state of chronic inflammation related to obesity impacts ovarian physiology due to insulin sensitivity impairment. The first-line treatment for adolescents with obesity and PCOS includes lifestyle changes; personalized dietary interventions; and, when needed, weight loss. Medical nutrition therapy (MNT) and the use of specific food supplements in these patients aim at improving symptoms and signs, including insulin resistance and metabolic and reproductive functions. The purpose of this narrative review is to present and discuss PCOS in adolescents with obesity, its relationship with IR and the role of MNT and food supplements in treatment. Appropriate early dietary intervention for the management of adolescents with obesity and PCOS should be considered as the recommended approach to restore ovulation and to protect fertility.
C1 [Calcaterra, Valeria; Tenuta, Elisavietta] Univ Pavia, Dept Internal Med, Pediat & Adolescent Unit, I-27100 Pavia, Italy.
   [Calcaterra, Valeria; Verduci, Elvira; Magenes, Vittoria Carlotta; Todisco, Carolina Federica; Bosetti, Alessandra; Di Profio, Elisabetta; Zuccotti, Gianvincenzo] Vittore Buzzi Childrens Hosp, Pediat Dept, I-20154 Milan, Italy.
   [Verduci, Elvira; Di Profio, Elisabetta] Univ Milan, Dept Hlth Sci, I-20142 Milan, Italy.
   [Cena, Hellas; Gregorio, Cristina; De Giuseppe, Rachele] Univ Pavia, Dept Publ Hlth Expt & Forens Med, Lab Dietet & Clin Nutr, I-27100 Pavia, Italy.
   [Cena, Hellas; Gregorio, Cristina; De Giuseppe, Rachele] ICS Maugeri IRCCS, Unit Internal Med & Endocrinol, Clin Nutr & Dietet Serv, I-27100 Pavia, Italy.
   [Magenes, Vittoria Carlotta; Todisco, Carolina Federica; Zuccotti, Gianvincenzo] Univ Milan, Dept Biomed & Clin Sci L Sacco, I-20157 Milan, Italy.
C3 University of Pavia; University of Milan; University of Pavia; Istituti
   Clinici Scientifici Maugeri IRCCS; University of Milan; Luigi Sacco
   Hospital
RP Calcaterra, V (corresponding author), Univ Pavia, Dept Internal Med, Pediat & Adolescent Unit, I-27100 Pavia, Italy.; Calcaterra, V (corresponding author), Vittore Buzzi Childrens Hosp, Pediat Dept, I-20154 Milan, Italy.
EM valeria.calcaterra@unipv.it; elvira.verduci@unimi.it;
   hellas.cena@unipv.it; vittoria.magenes@unimi.it;
   carolina.todisco@unimi.it; elisavietta.tenuta01@universitadipavia.it;
   cristina.gregorio@unimi.it; rachele.degiuseppe@unipv.it;
   alessandra.bosetti@asst-fbf-sacco.it; elisabetta.diprofio@unimi.it;
   gianyincenzo.zuccotti@unimi.it
RI Verduci, Elvira/D-7338-2014; Calcaterra, Valeria/AAB-7563-2022; Cena,
   Hellas/AAB-9995-2019; De Giuseppe, Rachele/K-4899-2018; Zuccotti,
   Gianvincenzo/H-8572-2017
OI Cena, Hellas/0000-0002-5752-6199; CALCATERRA,
   VALERIA/0000-0002-2137-5974; De Giuseppe, Rachele/0000-0002-5583-7735;
   Zuccotti, Gianvincenzo/0000-0002-2795-9874; Verduci,
   Elvira/0000-0003-2111-3111
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NR 234
TC 100
Z9 105
U1 4
U2 52
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JUN
PY 2021
VL 13
IS 6
AR 1848
DI 10.3390/nu13061848
PG 32
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA SZ1FR
UT WOS:000666320700001
PM 34071499
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Lindsay, KL
   Entringer, S
   Buss, C
   Wadhwa, PD
AF Lindsay, Karen L.
   Entringer, Sonja
   Buss, Claudia
   Wadhwa, Pathik D.
TI Intergenerational transmission of the effects of maternal exposure to
   childhood maltreatment on offspring obesity risk: A fetal programming
   perspective
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Review
DE Childhood obesity; Childhood maltreatment; Intergenerational
   transmission; Fetal programming; Pregnancy; Gestational biology
ID GESTATIONAL DIABETES-MELLITUS; INFANT-FEEDING PRACTICES; BODY-MASS
   INDEX; GUT MICROBIOTA; MITOCHONDRIAL DYSFUNCTION; INSULIN-RESISTANCE;
   METABOLIC SYNDROME; CARDIOMETABOLIC DISEASE; EPIGENETIC INHERITANCE;
   SOCIOECONOMIC-STATUS
AB Childhood obesity constitutes a major global public health challenge. A substantial body of evidence suggests that conditions and states experienced by the embryo/fetus in utero can result in structural and functional changes in cells, tissues, organ systems and homeostatic set points related to obesity. Furthermore, growing evidence suggests that maternal conditions and states experienced prior to conception, such as stress, obesity and metabolic dysfunction, may spill over into pregnancy and influence those key aspects of gestational biology that program offspring obesity risk. In this narrative review, we advance a novel hypothesis and life-span framework to propose that maternal exposure to childhood maltreatment may constitute an important and as-yet-under-appreciated risk factor implicated in developmental programming of offspring obesity risk via the long-term psychological, biological and behavioral sequelae of childhood maltreatment exposure. In this context, our framework considers the key role of maternal-placental-fetal endocrine, immune and metabolic pathways and also other processes including epigenetics, oocyte mitochondrial biology, and the maternal and infant microbiomes. Finally, our paper discusses future research directions required to elucidate the nature and mechanisms of the intergenerational transmission of the effects of maternal childhood maltreatment on offspring obesity risk.
C1 [Lindsay, Karen L.; Entringer, Sonja; Buss, Claudia; Wadhwa, Pathik D.] Univ Calif Irvine, Dept Pediat, Sch Med, Irvine, CA 92697 USA.
   [Wadhwa, Pathik D.] Univ Calif Irvine, Sch Med, Dept Psychiat & Human Behav, Irvine, CA 92697 USA.
   [Wadhwa, Pathik D.] Univ Calif Irvine, Sch Med, Dept Obstet & Gynecol, Irvine, CA 92697 USA.
   [Wadhwa, Pathik D.] Univ Calif Irvine, Dept Epidemiol, Sch Med, Irvine, CA 92697 USA.
   [Lindsay, Karen L.; Entringer, Sonja; Buss, Claudia; Wadhwa, Pathik D.] Univ Calif Irvine, Sch Med, Hlth & Dis Res Program, UCI Dev, Irvine, CA 92697 USA.
   [Entringer, Sonja; Buss, Claudia] Humboldt Univ, Freie Univ Berlin, Charite Univ Med Berlin, Berlin Inst Hlth BIH,Inst Med Psychol, Berlin, Germany.
C3 University of California System; University of California Irvine;
   University of California System; University of California Irvine;
   University of California System; University of California Irvine;
   University of California System; University of California Irvine;
   University of California System; University of California Irvine; Berlin
   Institute of Health; Free University of Berlin; Humboldt University of
   Berlin; Charite Universitatsmedizin Berlin
RP Wadhwa, PD (corresponding author), Univ Calif Irvine, Sch Med, Hlth & Dis Res Program, UC Irvine Dev,Neurosci Res Facil GNRF, 3117 Gillespie,837 Hlth Sci Rd, Irvine, CA 92697 USA.
EM pwadhwa@uci.edu
RI Lindsay, Karen/J-4383-2019; Entringer, Sonja/ABB-9405-2020; Buss,
   Claudia/ABC-3687-2020
OI Buss, Claudia/0000-0002-8738-3133; Lindsay, Karen/0000-0002-4481-9363;
   Entringer, Sonja/0000-0002-9926-7076
FU National Institutes of Health [K99 HD-096109, R01 MH-105538, R01
   MD-01078, R01 AG050455, UG3 OD-023349]; Eunice Kennedy Shriver National
   Institute of Child Health and Human Development [R00HD096109] Funding
   Source: NIH RePORTER
FX This work was supported by the National Institutes of Health, grant
   numbers K99 HD-096109, R01 MH-105538, R01 MD-01078, R01 AG050455 and UG3
   OD-023349. These funding sources had no role in the preparation and
   writing of the manuscript, or the decision to submit the paper for
   publication.
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NR 203
TC 11
Z9 11
U1 1
U2 23
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD JUN
PY 2020
VL 116
AR 104659
DI 10.1016/j.psyneuen.2020.104659
PG 12
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA LY7SQ
UT WOS:000540728400010
PM 32240906
OA Green Accepted, Green Submitted
DA 2025-06-11
ER

PT J
AU Faienza, MF
   Chiarito, M
   Molina-Molina, E
   Shanmugam, H
   Lammert, F
   Krawczyk, M
   D'Amato, G
   Portincasa, P
AF Faienza, Maria Felicia
   Chiarito, Mariangela
   Molina-Molina, Emilio
   Shanmugam, Harshitha
   Lammert, Frank
   Krawczyk, Marcin
   D'Amato, Gabriele
   Portincasa, Piero
TI Childhood obesity, cardiovascular and liver health: a growing epidemic
   with age
SO WORLD JOURNAL OF PEDIATRICS
LA English
DT Review
DE Cardiovascular; Childhood; Liver health; Obesity
ID INTIMA-MEDIA THICKNESS; BODY-MASS INDEX; FATTY LIVER; HEPATIC STEATOSIS;
   NONALCOHOLIC STEATOHEPATITIS; METABOLIC SYNDROME; PHYSICAL-ACTIVITY;
   OXIDATIVE STRESS; RISK-FACTORS; FOLLOW-UP
AB Background The frequency of childhood obesity has increased over the last 3 decades, and the trend constitutes a worrisome epidemic worldwide. With the raising obesity risk, key aspects to consider are accurate body mass index classification, as well as metabolic and cardiovascular, and hepatic consequences. Data sources The authors performed a systematic literature search in PubMed and EMBASE, using selected key words (obesity, childhood, cardiovascular, liver health). In particular, they focused their search on papers evaluating the impact of obesity on cardiovascular and liver health. Results We evaluated the current literature dealing with the impact of excessive body fat accumulation in childhood and across adulthood, as a predisposing factor to cardiovascular and hepatic alterations. We also evaluated the impact of physical and dietary behaviors starting from childhood on cardio-metabolic consequences. Conclusions The epidemic of obesity and obesity-related comorbidities worldwide raises concerns about the impact of early abnormalities during childhood and adolescence. Two key abnormalities in this context include cardiovascular diseases, and nonalcoholic fatty liver disease. Appropriate metabolic screenings and associated comorbidities should start as early as possible in obese children and adolescents. Nevertheless, improving dietary intake and increasing physical activity performance are to date the best therapeutic tools in children to weaken the onset of obesity, cardiovascular diseases, and diabetes risk during adulthood.
C1 [Faienza, Maria Felicia; Chiarito, Mariangela] Univ Bari Aldo Moro, Sect Pediat, Dept Biomed Sci & Human Oncol, Bari, Italy.
   [Molina-Molina, Emilio; Shanmugam, Harshitha; Portincasa, Piero] Univ Bari Aldo Moro, Clin Med A Murri, Dept Biomed Sci & Human Oncol, Bari, Italy.
   [Lammert, Frank; Krawczyk, Marcin] Saarland Univ, Dept Med 2, Med Ctr, Homburg, Germany.
   [Krawczyk, Marcin] Med Univ Warsaw, Lab Metab Liver Dis, Ctr Preclin Res, Dept Gen Transplant & Liver Surg, Warsaw, Poland.
   [D'Amato, Gabriele] Di Venere Hosp, Neonatal Intens Care Unit, Bari, Italy.
C3 Universita degli Studi di Bari Aldo Moro; Universita degli Studi di Bari
   Aldo Moro; Universitatsklinikum des Saarlandes; Medical University of
   Warsaw
RP Faienza, MF (corresponding author), Univ Bari Aldo Moro, Sect Pediat, Dept Biomed Sci & Human Oncol, Bari, Italy.
EM mariafelicia.faienza@uniba.it
RI portincasa, piero/J-7245-2018; Faienza, Maria/K-6779-2016; Shanmugam,
   Harshitha/LCE-0958-2024; Krawczyk, Marcin/AAG-4356-2020
OI Shanmugam, Harshitha/0000-0002-3711-2175; Molina Molina,
   Emilio/0000-0003-4390-5275; D'Amato, Gabriele/0000-0001-5160-9340;
   Krawczyk, Marcin/0000-0002-0113-0777
FU European Union [722619]; Foie Gras Early Research Training Grant
FX The present par develops in the context of the project FOIE GRAS, which
   has received funding from the European Union's Horizon 2020 Research and
   Innovation Program under the Marie Sklodowska-Curie Grant Agreement (No.
   722619). EMM and HS are recipients of Foie Gras Early Research Training
   Grant.
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NR 96
TC 62
Z9 69
U1 4
U2 28
PU ZHEJIANG UNIV SCH MEDICINE
PI HANGZHOU
PA CHILDRENS HOSPITAL, 57 ZHUGAN XIANG, HANGZHOU, 310003, PEOPLES R CHINA
SN 1708-8569
EI 1867-0687
J9 WORLD J PEDIATR
JI World Journal of Pediatrics
PD OCT
PY 2020
VL 16
IS 5
BP 438
EP 445
DI 10.1007/s12519-020-00341-9
EA FEB 2020
PG 8
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA NS7QP
UT WOS:000511048700002
PM 32020441
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Kobayashi, S
   Liang, QR
AF Kobayashi, Satoru
   Liang, Qiangrong
TI Autophagy and mitophagy in diabetic cardiomyopathy
SO BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
LA English
DT Review
DE Autophagy; Mitochondrion; Mitophagy; Diabetes; Diabetic cardiomyopathy
ID ACTIVATED PROTEIN-KINASE; TRIGGERS MITOCHONDRIA DEGRADATION;
   PARKIN-MEDIATED MITOPHAGY; DIET-INDUCED OBESITY; HIGH-RISK PATIENTS;
   CARDIAC AUTOPHAGY; CELL-DEATH; VITAMIN-E; CARDIOVASCULAR EVENTS;
   METABOLIC SYNDROME
AB Diabetic cardiomyopathy is a heart muscle-specific disease that increases the risk of heart failure and mortality in diabetic patients independent of vascular pathology. Mitochondria are cellular power plants that generate energy for heart contraction and concurrently produce reactive oxygen species that, if unchecked, may damage the mitochondria and the heart. Elimination of damaged mitochondria by autophagy known as mitophagy is an essential process for maintaining normal cardiac function at baseline and in response to various stress and disease conditions. Mitochondrial structural injury and functional impairment have been shown to contribute to diabetic heart disease. Recent studies have demonstrated an inhibited autophagic flux in the hearts of diabetic animals. Surprisingly, the diminished autophagy appears to be an adaptive response that protects against cardiac injury in type 1 diabetes. This raises several questions regarding the relationship between general autophagy and selective mitophagy in the diabetic heart. However, autophagy may play a different role in the hearts of type 2 diabetic animals. In this review, we will summarize current knowledge in this field and discuss the potential functional roles of autophagy and mitophagy in the pathogenesis of diabetic cardiomyopathy. This article is part of a Special Issue entitled: Autophagy and protein quality control in cardiometabolic diseases. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Kobayashi, Satoru; Liang, Qiangrong] Coll Osteopath Med, New York Inst Technol, Dept Biomed Sci, Old Westbury, NY 11568 USA.
C3 New York Institute Technology
RP Liang, QR (corresponding author), Coll Osteopath Med, New York Inst Technol, Dept Biomed Sci, Northern Blvd,POB 8000, Old Westbury, NY 11568 USA.
EM qliang03@nyit.edu
RI Liang, Weicheng/AER-7127-2022
FU American Diabetes Association [1-09-CD-09]; National Center for Research
   Resources [5P20RR017662-10]; National Institute of General Medical
   Sciences from the NIH [8 P20 GM103455-10]; juvenile Diabetes Research
   Foundation (JDRF) [10-2008-457]
FX The research in QL's laboratory was supported by a Career Development
   Grant (1-09-CD-09) from the American Diabetes Association and by grants
   from the National Center for Research Resources (5P20RR017662-10) and
   the National Institute of General Medical Sciences (8 P20 GM103455-10)
   from the NIH. SK was supported by an Advanced Postdoctoral Fellowship
   from the juvenile Diabetes Research Foundation (JDRF) (10-2008-457).
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NR 149
TC 170
Z9 188
U1 5
U2 52
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0925-4439
EI 0006-3002
J9 BBA-MOL BASIS DIS
JI Biochim. Biophys. Acta-Mol. Basis Dis.
PD FEB
PY 2015
VL 1852
IS 2
SI SI
BP 252
EP 261
DI 10.1016/j.bbadis.2014.05.020
PG 10
WC Biochemistry & Molecular Biology; Biophysics; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Cell Biology
GA CA5QR
UT WOS:000348963400009
PM 24882754
OA Bronze
DA 2025-06-11
ER

PT J
AU Mortensen, OH
   Larsen, LH
   Orstrup, LKH
   Hansen, LHL
   Grunnet, N
   Quistorff, B
AF Mortensen, Ole H.
   Larsen, Lea H.
   Orstrup, Laura K. H.
   Hansen, Lillian H. L.
   Grunnet, Niels
   Quistorff, Bjorn
TI Developmental programming by high fructose decreases phosphorylation
   efficiency in aging offspring brain mitochondria, correlating with
   enhanced UCP5 expression
SO JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
LA English
DT Article
DE aging; mitochondria; brain development; energy metabolism; gene
   regulation
ID PITUITARY-ADRENAL AXIS; OXIDATIVE-PHOSPHORYLATION; UNCOUPLING PROTEIN;
   METABOLIC SYNDROME; RATS; LACTATION; PREGNANCY; DIET; STRESS; MODELS
AB Fructose has recently been observed to affect brain metabolism and cognitive function in adults. Yet, possible late-onset effects by gestational fructose exposure have not been examined. We evaluated mitochondrial function in the brain of aging (15 months) male offspring of Fischer F344 rat dams fed a high-fructose diet (50% energy from fructose) during gestation and lactation. Maternal fructose exposure caused a significantly lower body weight of the offspring throughout life after weaning, while birth weight, litter size, and body fat percentage were unaffected.-Isolated brain mitochondria displayed a significantly increased state 3 respiration of 8%, with the substrate combinations malate/pyruvate, malate/pyruvate/succinate, and malate/pyruvate/succiriate/rotenone, as well as a significant decrease in the P/O-2 ratio, compared with the control. Uncoupling protein 5 (UCP5) protein levels increased in the-fructose group compared with the control (P=0.03) and both UCP5 mRNA and protein levels were inversely correlated with the P/O-2 ratio (P=0.008 and 0.03, respectively), suggesting that UCP5 may have a role in the observed decreased phosphorylation efficiency. In conclusion, maternal high-fructose diet during gestation and lactation has long-term effects (fetal programming) on brain mitochondrial function in aging rats, which appears to be linked to an increase in UCP5 protein levels.
C1 [Mortensen, Ole H.; Larsen, Lea H.; Orstrup, Laura K. H.; Hansen, Lillian H. L.; Grunnet, Niels; Quistorff, Bjorn] Univ Copenhagen, Dept Biomed Sci, Fac Hlth & Med Sci, DK-2200 Copenhagen N, Denmark.
C3 University of Copenhagen
RP Mortensen, OH (corresponding author), Univ Copenhagen, Dept Biomed Sci, Panum 6-5,Blegdamsvej 3, DK-2200 Copenhagen N, Denmark.
EM ole@hartvig.org
RI Mortensen, Ole/AAA-8835-2019
OI Mortensen, Ole Hartvig/0000-0003-1118-6317
FU Danish Strategic Research Council [09-067124, 09-059921]; Danish Medical
   Research Council [271-07-0732, 09-073413]; Kobmand i Odense Johann og
   Hanne Weimann f. Seedorffs Legat; Gangstedfonden; Ernst Fischers
   mindelegat; Eva og Hans Carl Adolfs Mindelegat; Direktor Emil Hertz og
   Hustru Inger Hertz Fond
FX This research was supported by The Danish Strategic Research Council
   grant #09-067124 and #09-059921, Danish Medical Research Council grant
   #271-07-0732 and #09-073413, by Kobmand i Odense Johann og Hanne Weimann
   f. Seedorffs Legat, Gangstedfonden, Ernst Fischers mindelegat, Eva og
   Hans Carl Adolfs Mindelegat, and Direktor Emil Hertz og Hustru Inger
   Hertz Fond.
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NR 41
TC 22
Z9 23
U1 0
U2 9
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 0271-678X
EI 1559-7016
J9 J CEREBR BLOOD F MET
JI J. Cereb. Blood Flow Metab.
PD JUL
PY 2014
VL 34
IS 7
BP 1205
EP 1211
DI 10.1038/jcbfm.2014.72
PG 7
WC Endocrinology & Metabolism; Hematology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Hematology; Neurosciences & Neurology
GA AK7JT
UT WOS:000338605300017
PM 24756078
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Yang, MH
   Cho, J
   Choi, YH
   Son, HJ
   Rhee, JC
   Sung, J
AF Yang, M. H.
   Cho, J.
   Choi, Y. H.
   Son, H. J.
   Rhee, J. C.
   Sung, J.
TI The Association between Coronary Artery Calcification and Colorectal
   Adenoma
SO HEPATO-GASTROENTEROLOGY
LA English
DT Article
DE Colorectal adenoma; Screening colonoscopy; Coronary artery calcification
ID COMPUTED-TOMOGRAPHY; INSULIN-RESISTANCE; METABOLIC SYNDROME; OXIDATIVE
   STRESS; COLON-CANCER; RISK-FACTOR; DISEASE; INFLAMMATION; ANGIOGRAPHY;
   ASIA
AB Background/Aims: Both colorectal neoplasm and coronary artery disease are prevalent diseases worldwide and share several risk factors. The aim of this study was to investigate the association between coronary artery calcification and prevalence of colorectal adenoma. Methodology: We retrospectively evaluated 3,092 subjects who underwent colonoscopy and coronary artery calcium computed tomography (CT) on the same day or within a 3-month interval, during routine check-ups between January 2006 and June 2009 at the Center for Health Promotion of the Samsung Medical Center. Multivariate logistic regression analysis was used to calculate adjusted odds ratios (ORs). Results: Colorectal adenomas were detected in 1,067 (34.5%) of the 3,092 subjects, including 536 (41.0%) individuals with and 531 (29.7%) without Coronary calcification (p<0.001). Multiple logistic regression analysis showed that the presence of coronary artery calcification (OR=1.346; 95% confidence interval [CI]=1.122-1.614), age >= 50 years (OR=1.516; 95% CI=1.256-1.829), waist circumference of 9099 cm (OR=1.364; 95% CI=1.008-1.844) and current smoker (OR=1.266; 95% CI=1.045-1.534) were associated with the prevalence of colorectal adenoma. Conclusions: The prevalence of colorectal adenoma is significantly higher in patients with coronary artery calcification. Our results support positive relationship between coronary artery disease and colorectal adenoma.
C1 [Yang, M. H.; Choi, Y. H.; Son, H. J.; Sung, J.] Johns Hopkins Univ, Bloomberg Sch Pibl Helath, Ctr Hlth Promot, Baltmore, MD USA.
   [Cho, J.] Johns Hopkins Univ, Bloomberg Sch Pibl Helath, Departmne Hlth Sci & Technol, Adv Inst Helath Sci & Technol, Baltmore, MD USA.
   [Cho, J.; Choi, Y. H.] Johns Hopkins Univ, Bloomberg Sch Pibl Helath, Dept Epidemiol & Hlth Behav & Soc, Baltmore, MD USA.
   [Son, H. J.; Rhee, J. C.; Sung, J.] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Med, Seoul 135710, South Korea.
C3 Johns Hopkins University; Johns Hopkins Bloomberg School of Public
   Health; Johns Hopkins University; Johns Hopkins Bloomberg School of
   Public Health; Johns Hopkins University; Johns Hopkins Bloomberg School
   of Public Health; Sungkyunkwan University (SKKU); Samsung Medical Center
RP Sung, J (corresponding author), Sungkyunkwan Univ, Sch Med, Ctr Hlth Promot, Div Cardiol,Dept Med,Samsung Med Ctr, Seoul 135710, South Korea.
EM jdsung@skku.edu
RI sung, jd/O-5936-2014
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NR 29
TC 6
Z9 6
U1 0
U2 7
PU H G E UPDATE MEDICAL PUBLISHING S A
PI ATHENS
PA PO BOX 17257, ATHENS GR-10024, GREECE
SN 0172-6390
J9 HEPATO-GASTROENTEROL
JI Hepato-Gastroenterol.
PD MAY
PY 2013
VL 60
IS 123
BP 538
EP 542
DI 10.5754/hge12709
PG 5
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA 168XF
UT WOS:000320740500029
PM 23108081
DA 2025-06-11
ER

PT J
AU Kaur, P
   Rizk, NM
   Ibrahim, S
   Younes, N
   Uppal, A
   Dennis, K
   Karve, T
   Blakeslee, K
   Kwagyan, J
   Zirie, M
   Ressom, HW
   Cheema, AK
AF Kaur, Prabhjit
   Rizk, Nasser M.
   Ibrahim, Sereen
   Younes, Noura
   Uppal, Arushi
   Dennis, Kevin
   Karve, Tejaswita
   Blakeslee, Kenneth
   Kwagyan, John
   Zirie, Mahmoud
   Ressom, Habtom W.
   Cheema, Amrita K.
TI iTRAQ-Based Quantitative Protein Expression Profiling and MRM
   Verification of Markers in Type 2 Diabetes
SO JOURNAL OF PROTEOME RESEARCH
LA English
DT Article
DE Diabetes; Proteomics; Biomarkers; MRM; metabolic syndrome
ID RETINOL-BINDING-PROTEIN; CHRONIC KIDNEY-DISEASE; VITAMIN-D;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; GEL-ELECTROPHORESIS;
   SELENOPROTEIN-P; SERUM; PLASMA; RISK
AB The pathogenesis of Type 2 diabetes mellitus (T2DM) is complex owing to molecular heterogeneity in the afflicted population. Current diagnostic methods rely on blood glucose measurements, which are noninformative with respect to progression of the disease to other associated pathologies. Thus, predicting the risk and development of T2DM-related complications, such as cardiovascular disease, remains a major challenge. We have used a combination of quantitative methods for characterization of circulating serum biomarkers of T2DM using a cohort of nondiabetic control subjects (n = 76) and patients diagnosed with T2DM (n = 106). In this case control study, the samples were randomly divided as training and validation data sets. In the first step, iTRAQ (isobaric tagging for relative and absolute quantification) based protein expression profiling was performed for identification of proteins displaying a significant differential expression in the two study groups. Five of these protein markers were selected for validation using multiple reaction-monitoring mass spectrometry (MRM-MS) and further confirmed with Western blot and QPCR analysis. Functional pathway analysis identified perturbations in lipid and small molecule metabolism as well as pathways that lead to disruption of glucose homeostasis and blood coagulation. These putative biomarkers may be clinically useful for subset stratification of T2DM patients as well as for the development of novel therapeutics targeting the specific pathology.
C1 [Kaur, Prabhjit; Uppal, Arushi; Dennis, Kevin; Karve, Tejaswita; Ressom, Habtom W.; Cheema, Amrita K.] Georgetown Univ, Med Ctr, Dept Oncol, Lombardi Comprehens Canc Ctr, Washington, DC 20007 USA.
   [Rizk, Nasser M.; Ibrahim, Sereen] Qatar Univ, Dept Hlth Sci, Doha, Qatar.
   [Younes, Noura; Zirie, Mahmoud] Hamad Med Corp, Doha, Qatar.
   [Blakeslee, Kenneth] Waters Corp, Washington, DC USA.
   [Kwagyan, John] Howard Univ, Coll Med, Washington, DC USA.
C3 Georgetown University; Qatar University; Hamad Medical Corporation;
   Waters Corporation; Howard University
RP Cheema, AK (corresponding author), Georgetown Univ, Med Ctr, Dept Oncol, Lombardi Comprehens Canc Ctr, Washington, DC 20007 USA.
EM akc27@georgetown.edu
RI kaur, prabhjit/HHS-3727-2022; Rizk, Nasser/C-5174-2015
OI Rizk, Nasser/0000-0002-6288-3609; Zirie, Mahmoud/0000-0002-3842-5923;
   Cheema, Amrita/0000-0003-4877-7583; Rizk, Nasser/0000-0001-7629-1332
FU NPRP from the Qatar National Research Fund (Qatar Foundation)
   [08-740-3-148]; NIH/NCI [P30-CA051008]; clinical laboratory Hamad
   Medical Corporation (Doha, Qatar)
FX This publication was made possible by NPRP Grant No. 08-740-3-148 from
   the Qatar National Research Fund (a member of Qatar Foundation). The
   statements made herein are solely the responsibility of the authors. The
   authors acknowledge the Proteomics and Metabolomics shared resource and
   the Genomics and Epigenomics Shared Resource, supported in part by
   NIH/NCI Grant P30-CA051008, and the clinical laboratory Hamad Medical
   Corporation (Doha, Qatar). The authors also thank Dr. Anju Preet for
   helping with the optimization of QPCR assay with serum samples and Dr.
   Troy Sulahian (Waters Corporation) for help with peptide MRM assays. The
   authors also thank Nusep, Inc. for providing the beta version of the
   ProteolQ software for iTRAQ data analysis.
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NR 75
TC 62
Z9 63
U1 0
U2 38
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1535-3893
EI 1535-3907
J9 J PROTEOME RES
JI J. Proteome Res.
PD NOV
PY 2012
VL 11
IS 11
BP 5527
EP 5539
DI 10.1021/pr300798z
PG 13
WC Biochemical Research Methods
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 038RA
UT WOS:000311190600035
PM 23050762
DA 2025-06-11
ER

PT J
AU Tack, CJ
   Stienstra, R
   Joosten, LAB
   Netea, MG
AF Tack, Cees J.
   Stienstra, Rinke
   Joosten, Leo A. B.
   Netea, Mihai G.
TI Inflammation links excess fat to insulin resistance: the role of the
   interleukin-1 family
SO IMMUNOLOGICAL REVIEWS
LA English
DT Review
DE insulin resistance; interleukin-1; autophagy; inflammasome; anakinra;
   visceral fat
ID THIOREDOXIN-INTERACTING PROTEIN; NECROSIS-FACTOR-ALPHA; SUBCUTANEOUS
   ADIPOSE-TISSUE; NF-KAPPA-B; BETA-CELL; RECEPTOR ANTAGONIST; CASPASE-1
   ACTIVATION; NLRP3 INFLAMMASOME; METABOLIC SYNDROME; OXIDATIVE STRESS
AB A growing body of evidence suggests that cytokines of the interleukin-1 (IL-1) family, particularly IL-1 beta but also IL-1Ra and IL-18, are involved in obesity-associated inflammation. IL-1 beta is produced via cleavage of pro-IL-1 beta by caspase-1, which in turn is activated by a multiprotein complex called the inflammasome. The components of the NLRP3 inflammasome are involved in sensing obesity-associated danger signals, both in mice and in human (obese) subjects, with caspase-1 seemingly the most crucial regulator. Autophagy is upregulated in obesity and may function as a mechanism to control IL-1 beta gene expression in adipose tissue to mitigate chronic inflammation. All these mechanisms are operative in human adipose tissue and appear to be more pronounced in human visceral compared to subcutaneous tissue. In animal studies, blocking caspase-1 activity results in decreased weight gain, decreased inflammation, and improved insulin sensitivity. Human intervention studies with IL-1Ra (anakinra) have reported beneficial effects in patients with diabetes, yet without significant changes in insulin sensitivity. Clearly, the IL-1 family of cytokines, especially IL-1 beta, plays an important role in obesity-associated inflammation and insulin resistance and may represent a therapeutic target to reverse the detrimental metabolic consequences of obesity.
C1 [Tack, Cees J.; Stienstra, Rinke; Joosten, Leo A. B.; Netea, Mihai G.] Radboud Univ Nijmegen, Med Ctr, Dept Internal Med, NL-6500 HB Nijmegen, Netherlands.
   [Joosten, Leo A. B.; Netea, Mihai G.] Radboud Univ Nijmegen, Med Ctr, Nijmegen Inst Infect Inflammat & Immun N4i, NL-6500 HB Nijmegen, Netherlands.
   [Stienstra, Rinke] Wageningen Univ, Nutr Metab & Genom Grp, Wageningen, Netherlands.
C3 Radboud University Nijmegen; Radboud University Nijmegen; Wageningen
   University & Research
RP Tack, CJ (corresponding author), Radboud Univ Nijmegen, Med Ctr, Dept Internal Med 463, POB 9101, NL-6500 HB Nijmegen, Netherlands.
EM c.tack@aig.umcn.nl
RI Stienstra, Rinke/A-4763-2015; Netea, Mihai/N-5155-2014; Tack,
   Cees/A-2368-2014; Joosten, Leo/H-3138-2015
FU Netherlands DiabetesFonds; Netherlands Organization for Scientific
   Research
FX R. S. was supported by a Ruby grant of the Netherlands DiabetesFonds. M.
   G. N. was supported by a Vici grant of the Netherlands Organization for
   Scientific Research. The authors have no conflicts of interest to
   declare.
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NR 129
TC 153
Z9 171
U1 0
U2 36
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0105-2896
EI 1600-065X
J9 IMMUNOL REV
JI Immunol. Rev.
PD SEP
PY 2012
VL 249
SI SI
BP 239
EP 252
DI 10.1111/j.1600-065X.2012.01145.x
PG 14
WC Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology
GA 989NO
UT WOS:000307567300016
PM 22889226
DA 2025-06-11
ER

PT J
AU van Zonneveld, SM
   van den Oever, EJ
   Haarman, BCM
   Grandjean, EL
   Nuninga, JO
   van de Rest, O
   Sommer, IEC
AF van Zonneveld, Sophie M.
   van den Oever, Ellen J.
   Haarman, Benno C. M.
   Grandjean, Emmy L.
   Nuninga, Jasper O.
   van de Rest, Ondine
   Sommer, Iris E. C.
TI An Anti-Inflammatory Diet and Its Potential Benefit for Individuals with
   Mental Disorders and Neurodegenerative Diseases-A Narrative Review
SO NUTRIENTS
LA English
DT Review
DE mental disorders; neurodegenerative diseases; inflammation; gut
   microbiome; anti-inflammatory diet; food groups
ID C-REACTIVE PROTEIN; DOSE-RESPONSE METAANALYSIS; MILD COGNITIVE
   IMPAIRMENT; PLACEBO-CONTROLLED TRIAL; VIRGIN OLIVE OIL;
   PARKINSONS-DISEASE; METABOLIC SYNDROME; MEDITERRANEAN DIET;
   DOUBLE-BLIND; GASTROINTESTINAL MICROBIOME
AB This narrative review synthesizes current evidence regarding anti-inflammatory dietary patterns and their potential benefits for individuals with mental disorders and neurodegenerative diseases. Chronic low-grade inflammation is increasingly recognized as a key factor in the etiology and progression of these conditions. The review examines the evidence for the anti-inflammatory and neuroprotective properties of dietary components and food groups, focusing on whole foods rather than specific nutrients or supplements. Key dietary components showing potential benefits include fruits and vegetables (especially berries and leafy greens), whole grains, legumes, fatty fish rich in omega-3, nuts (particularly walnuts), olive oil, and fermented foods. These foods are generally rich in antioxidants, dietary fiber, and bioactive compounds that may help modulate inflammation, support gut health, and promote neuroprotection. Conversely, ultra-processed foods, red meat, and sugary beverages may be harmful. Based on this evidence, we designed the Brain Anti-Inflammatory Nutrition (BrAIN) diet. The mechanisms of this diet include the modulation of the gut microbiota and the gut-brain axis, the regulation of inflammatory pathways, a reduction in oxidative stress, and the promotion of neuroplasticity. The BrAIN diet shows promise as an aid to manage mental and neurodegenerative disorders.
C1 [van Zonneveld, Sophie M.; van den Oever, Ellen J.; Grandjean, Emmy L.; Nuninga, Jasper O.; Sommer, Iris E. C.] Univ Groningen, Univ Med Ctr Groningen, Dept Biomed Sci, Cognit Neurosci Ctr, NL-9713 GZ Groningen, Netherlands.
   [Haarman, Benno C. M.; Sommer, Iris E. C.] Univ Groningen, Univ Med Ctr Groningen, Dept Psychiat, NL-9713 GZ Groningen, Netherlands.
   [van de Rest, Ondine] Wageningen Univ & Res, Dept Human Nutr & Hlth, NL-6708 WE Wageningen, Netherlands.
C3 University of Groningen; University of Groningen; Wageningen University
   & Research
RP van Zonneveld, SM (corresponding author), Univ Groningen, Univ Med Ctr Groningen, Dept Biomed Sci, Cognit Neurosci Ctr, NL-9713 GZ Groningen, Netherlands.
EM s.m.van.zonneveld@umcg.nl
RI Haarman, Benno/JUV-5321-2023
OI van Zonneveld, Sophie/0000-0001-6701-4026
FU Stanley Medical Research Institute; ZonMW [636320010]; Hersenstichting
   [JP-06];  [18T-004]
FX This study was supported by grants from the Stanley Medical Research
   Institute (18T-004), ZonMW (636320010), and Hersenstichting (JP-06). The
   funding organizations had no further role in the study design;
   collection, analysis and interpretation of data, the writing of the
   report and the decision to submit the paper for publication.
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NR 159
TC 10
Z9 10
U1 5
U2 12
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD AUG
PY 2024
VL 16
IS 16
AR 2646
DI 10.3390/nu16162646
PG 18
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA E9D7T
UT WOS:001305939300001
PM 39203783
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Baz, L
   Algarni, S
   Al-Thepyani, M
   Aldairi, A
   Gashlan, H
AF Baz, Lina
   Algarni, Salha
   Al-Thepyani, Mona
   Aldairi, Abdullah
   Gashlan, Hana
TI Lycopene Improves Metabolic Disorders and Liver Injury Induced by a
   Hight-Fat Diet in Obese Rats
SO MOLECULES
LA English
DT Article
DE lycopene; high-fat diet; obesity; antioxidants; inflammatory; lipid
   peroxidation
ID ADIPOSE-TISSUE; APO-10'-LYCOPENOIC ACID; INSULIN-RESISTANCE; OXIDATIVE
   STRESS; GUT MICROBIOTA; POTENTIAL ROLE; INFLAMMATION; DISEASE; LEPTIN;
   MICE
AB Epidemiological studies have shown that the consumption of a high-fat diet (HFD) is positively related to the development of obesity. Lycopene (LYC) can potentially combat HFD-induced obesity and metabolic disorders in rats. This study aimed to investigate the effect of LYC on metabolic syndrome and assess its anti-inflammatory and antioxidant effects on the liver and adipose tissue in rats fed an HFD. Thirty-six male Wistar albino rats were divided into three groups. Group Iota (the control group) was fed a normal diet, group Iota Iota (HFD) received an HFD for 16 weeks, and group Iota Iota Iota (HFD + LYC) received an HFD for 12 weeks and then LYC (25 mg/kg b.wt) was administered for four weeks. Lipid peroxidation, antioxidants, lipid profile, liver function biomarkers, and inflammatory markers were determined. The results showed that long-term consumption of an HFD significantly increased weight gain, liver weight, and cholesterol and triglyceride levels. Rats on an HFD displayed higher levels of lipid peroxidation and inflammatory markers. Moreover, liver and white adipose tissue histopathological investigations showed that LYC treatment mended the damaged tissue. Overall, LYC supplementation successfully reversed HFD-induced changes and shifts through its antioxidant and anti-inflammatory activity. Therefore, LYC displayed a therapeutic potential to manage obesity and its associated pathologies.
C1 [Baz, Lina; Algarni, Salha; Al-Thepyani, Mona; Gashlan, Hana] King Abdulaziz Univ, Fac Sci, Dept Biochem, Jeddah 21589, Saudi Arabia.
   [Al-Thepyani, Mona] King Abdulaziz Univ, Coll Sci & Art, Dept Chem, Rabigh 21911, Saudi Arabia.
   [Aldairi, Abdullah] Umm Al Qura Univ, Fac Appl Med Sci, Dept Lab Med, Mecca 24211, Saudi Arabia.
C3 King Abdulaziz University; King Abdulaziz University; Umm Al-Qura
   University
RP Baz, L (corresponding author), King Abdulaziz Univ, Fac Sci, Dept Biochem, Jeddah 21589, Saudi Arabia.
EM lbaz@kau.edu.sa
RI Aldairi, Abdullah/AHC-3962-2022; Baz, Lina/ABC-2412-2020; Gashlan,
   Hana/ABC-4817-2020; Althepyani, Mona/AAX-4984-2020
OI Althepyani, Mona/0000-0003-3071-6854; Aldairi,
   Abdullah/0000-0003-2861-6299
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NR 107
TC 10
Z9 10
U1 2
U2 18
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1420-3049
J9 MOLECULES
JI Molecules
PD NOV
PY 2022
VL 27
IS 22
AR 7736
DI 10.3390/molecules27227736
PG 16
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 6L4BD
UT WOS:000888128600001
PM 36431836
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Opazo-Ríos, L
   Soto-Catalán, M
   Lázaro, I
   Sala-Vila, A
   Jiménez-Castilla, L
   Orejudo, M
   Moreno, JA
   Egido, J
   Mas-Fontao, S
AF Opazo-Rios, Lucas
   Soto-Catalan, Manuel
   Lazaro, Iolanda
   Sala-Vila, Aleix
   Jimenez-Castilla, Luna
   Orejudo, Macarena
   Antonio Moreno, Juan
   Egido, Jesus
   Mas-Fontao, Sebastian
TI Meta-Inflammation and De Novo Lipogenesis Markers Are Involved in
   Metabolic Associated Fatty Liver Disease Progression in BTBR ob/ob Mice
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE metabolic associated fatty liver disease; BTBR ob; ob; de novo
   lipogenesis; meta-inflammation
ID INSULIN-RESISTANCE; GENE-EXPRESSION; NONALCOHOLIC STEATOHEPATITIS;
   HEPATIC STEATOSIS; ACIDS; SEPARATION; LIPIDS; MODEL
AB Metabolic associated fatty liver disease (MAFLD) is a hepatic manifestation of metabolic syndrome and usually associated with obesity and diabetes. Our aim is to characterize the pathophysiological mechanism involved in MAFLD development in Black Tan and brachyuric (BTBR) insulin-resistant mice in combination with leptin deficiency (ob/ob). We studied liver morphology and biochemistry on our diabetic and obese mice model (BTBR ob/ob) as well as a diabetic non-obese control (BTBR + streptozotocin) and non-diabetic control mice (BTBR wild type) from 4-22 weeks. Lipid composition was assessed, and lipid related pathways were studied at transcriptional and protein level. Microvesicular steatosis was evident in BTBR ob/ob from week 6, progressing to macrovesicular in the following weeks. At 12th week, inflammatory clusters, activation of STAT3 and Nrf2 signaling pathways, and hepatocellular ballooning. At 22 weeks, the histopathological features previously observed were maintained and no signs of fibrosis were detected. Lipidomic analysis showed profiles associated with de novo lipogenesis (DNL). BTBR ob/ob mice develop MAFLD profile that resemble pathological features observed in humans, with overactivation of inflammatory response, oxidative stress and DNL signaling pathways. Therefore, BTBR ob/ob mouse is an excellent model for the study of the steatosis to steatohepatitis transition.
C1 [Opazo-Rios, Lucas; Soto-Catalan, Manuel; Jimenez-Castilla, Luna; Orejudo, Macarena; Egido, Jesus; Mas-Fontao, Sebastian] Univ Autonoma Madrid, IIS Fdn Jimenez Diaz, Spanish Biomed Res Ctr Diabet & Associated Metab, Renal Vasc & Diabet Res Lab, Madrid 28040, Spain.
   [Opazo-Rios, Lucas] Univ Amer, Fac Ciencias Salud, Concepcion 4301099, Chile.
   [Lazaro, Iolanda; Sala-Vila, Aleix] Hosp del Mar Med Res Inst IMIM, Barcelona 08003, Spain.
   [Antonio Moreno, Juan] Univ Cordoba, Dept Cell Biol Physiol & Immunol, Cordoba 14004, Spain.
   [Antonio Moreno, Juan] Hosp Univ Reina Sofia, Maimonides Biomed Res Inst Cordoba IMIBIC, UGC Nephrol, Cordoba 14004, Spain.
C3 Autonomous University of Madrid; Fundacion Jimenez Diaz; Universidad de
   Las Americas - Chile; Hospital del Mar Research Institute; Hospital del
   Mar; Universidad de Cordoba
RP Opazo-Ríos, L; Mas-Fontao, S (corresponding author), Univ Autonoma Madrid, IIS Fdn Jimenez Diaz, Spanish Biomed Res Ctr Diabet & Associated Metab, Renal Vasc & Diabet Res Lab, Madrid 28040, Spain.; Opazo-Ríos, L (corresponding author), Univ Amer, Fac Ciencias Salud, Concepcion 4301099, Chile.
EM lopazo@udla.cl; manuel.soto.catalan@gmail.com; iolan.lazaro@gmail.com;
   asala3@imim.es; luna.jimenez@quironsalud.es;
   macarena.orejudo@quironsalud.es; jamoreno@fjd.es; jegido@quironsalud.es;
   smas@fjd.es
RI del Río, Macarena/B-8989-2018; Moreno, Juan/B-3487-2018; Opazo-Ríos,
   Lucas/AEM-3058-2022; Soto Catalán, Manuel/AGQ-4326-2022; Mas,
   S/T-1489-2018; LOPEZ, IOLANDA/L-5393-2014
OI Mas, Sebastian/0000-0001-6604-3327; Moreno Gutierrez, Juan
   Antonio/0000-0002-7468-2871; OPAZO RIOS, LUCAS/0000-0003-3586-3319; Soto
   Catalan, Manuel/0000-0003-3500-4637; LAZARO, IOLANDA/0000-0002-6172-9845
FU Instituto de Salud Carlos III (European Regional Development
   Fund/European Social Fund "A way to make Europe"/"Investing in your
   future") [PI17/00130, PI20/00375, PI20/00487, DTS19/00093]; Spanish
   Biomedical Research Centre in Cardiovascular Diseases (CIBERCV);
   Consejeria de Salud y Familias-FEDER, Junta de Andalucia
   [PIGE-0052-2020]; Consejeria de Economia, Conocimiento, Empresas y
   Universidad [1381179-R]; Spanish Society of Nephrology (SEN); Spanish
   Ministry of Science and Innovation/State Investigation Agency (European
   Regional Development Fund/European Social Fund "A way to make
   Europe"/"Investing in your future") [RYC-2017-22369]
FX This research was funded by Instituto de Salud Carlos III (PI17/00130,
   PI20/00375, PI20/00487; and DTS19/00093 (Co-funded by European Regional
   Development Fund/European Social Fund "A way to make Europe"/"Investing
   in your future"), Spanish Biomedical Research Centre in Cardiovascular
   Diseases (CIBERCV), Consejeria de Salud y Familias-FEDER, Junta de
   Andalucia (PIGE-0052-2020), Consejeria de Economia, Conocimiento,
   Empresas y Universidad (1381179-R) and Spanish Society of Nephrology
   (SEN). The Spanish Ministry of Science and Innovation/State
   Investigation Agency (10.13039/501100011033) supported the salary of JAM
   (RYC-2017-22369, Co-funded by European Regional Development
   Fund/European Social Fund "A way to make Europe"/"Investing in your
   future").
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NR 53
TC 10
Z9 10
U1 1
U2 10
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD APR
PY 2022
VL 23
IS 7
AR 3965
DI 10.3390/ijms23073965
PG 18
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 0L4KH
UT WOS:000781444000001
PM 35409324
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU McCartney, DMA
   Byrne, DG
   Turner, MJ
AF McCartney, D. M. A.
   Byrne, D. G.
   Turner, M. J.
TI Dietary contributors to hypertension in adults reviewed
SO IRISH JOURNAL OF MEDICAL SCIENCE
LA English
DT Review
DE Hypertension; Diet; Nutrients; Adults
ID SWEETENED BEVERAGE CONSUMPTION; REDUCE BLOOD-PRESSURE; METABOLIC
   SYNDROME; OXIDATIVE STRESS; SODIUM-INTAKE; WEIGHT-GAIN; SALT REDUCTION;
   FOOD; HOMOCYSTEINE; PREVALENCE
AB Recent national surveys which measured respondents' blood pressure (BP) levels have shown a high prevalence of hypertension amongst the Irish population, with approximately two-thirds of men and over half of women aged 45 years and over affected. Higher prevalence rates are observed with advancing age. Established diet- and lifestyle-related risk factors for hypertension such as high salt intake, high alcohol consumption and physical inactivity are pervasive in Ireland and are believed to contribute significantly to the high national prevalence of this condition. Additional dietary deficits have been implicated in the development of hypertension, however, including low fruit and vegetable intake, low dairy food consumption and low intake of oily fish. Deficiencies of single micro-nutrients such as folate, riboflavin, vitamin C and vitamin D have also been recently recognised as risk factors for hypertension. For each of these factors, there is evidence that the food and nutrient intakes of many Irish adults fall short of the ideal. These dietary and nutritional deficits, when superimposed on Ireland's existing health-subversive behaviours and escalating rates of obesity, constitute a potent constellation of risk factors for hypertension. However, they also represent viable and potentially effective targets for health promotion initiatives. This review aims to describe the main nutritional, dietary and lifestyle contributors to hypertension in Ireland with a view to informing future interventions aimed at alleviating Ireland's burden of hypertensive disease.
C1 [McCartney, D. M. A.] Dublin Inst Technol, Sch Biol Sci, Dublin 8, Ireland.
   [Byrne, D. G.] St James Hosp, Dept Gen Med, GEMS Directorate, Dublin 8, Ireland.
   [Byrne, D. G.] Univ Dublin Trinity Coll, Dept Med Gerontol, Dublin 2, Ireland.
   [Turner, M. J.] Coombe Women & Infants Univ Hosp, Dept Obstet & Gynaecol, UCD Ctr Human Reprod, Dublin 8, Ireland.
C3 Technological University Dublin; Trinity College Dublin; Trinity College
   Dublin
RP McCartney, DMA (corresponding author), Dublin Inst Technol, Sch Biol Sci, Kevin St, Dublin 8, Ireland.
EM daniel.mccartney@dit.ie
RI Turner, Mark/AAN-1876-2020; Byrne, Declan/J-5078-2019
OI Byrne, Declan/0000-0002-1836-4043; Turner, Michael/0000-0003-0064-5098
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NR 71
TC 16
Z9 20
U1 0
U2 26
PU SPRINGER LONDON LTD
PI LONDON
PA 236 GRAYS INN RD, 6TH FLOOR, LONDON WC1X 8HL, ENGLAND
SN 0021-1265
EI 1863-4362
J9 IRISH J MED SCI
JI Irish J. Med. Sci.
PD MAR
PY 2015
VL 184
IS 1
BP 81
EP 90
DI 10.1007/s11845-014-1181-5
PG 10
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA CE5AB
UT WOS:000351840900010
PM 25150713
DA 2025-06-11
ER

PT J
AU Stuebe, AM
   Mantzoros, C
   Kleinman, K
   Gillman, MW
   Rifas-Shiman, S
   Gunderson, EP
   Rich-Edwards, J
AF Stuebe, Alison M.
   Mantzoros, Christos
   Kleinman, Ken
   Gillman, Matthew W.
   Rifas-Shiman, Sheryl
   Gunderson, Erica P.
   Rich-Edwards, Janet
TI Duration of Lactation and Maternal Adipokines at 3 Years Postpartum
SO DIABETES
LA English
DT Article
ID TOTAL GHRELIN CONCENTRATIONS; PEPTIDE-YY; INSULIN-RESISTANCE; PLASMA
   GHRELIN; STRESS; RISK; HYPERTENSION; ADIPONECTIN; ADIPOSITY; RESPONSES
AB OBJECTIVE-Lactation has been associated with reduced maternal risk of type 2 diabetes, the metabolic syndrome, and cardiovascular disease. We examined the relationship between breastfeeding duration and maternal adipokines at 3 years postpartum.
   RESEARCH DESIGN AND METHODS-We used linear regression to relate the duration of lactation to maternal leptin, adiponectin, ghrelin, and peptide YY (PYY) at 3 years postpartum among 570 participants with 3-year postpartum blood samples (178 fasting), prospectively collected lactation history, and no intervening pregnancy in Project Viva, a cohort study of mothers and children.
   RESULTS-A total of 88% of mothers had initiated breastfeeding, 26% had breastfed >= 12 months, and 42% had exclusively breastfed for >= 3 months. In multivariate analyses, we found that duration of total breastfeeding was directly related to PYY and ghrelin, and exclusive breastfeeding duration was directly related to ghrelin (predicted mean for never exclusively breastfeeding: 790.6 pg/mL vs. >= 6 months of exclusive breastfeeding: 1,008.1 pg/mL; P < 0.01) at 3 years postpartum, adjusting for pregravid BMI, gestational weight gain, family history of diabetes, parity, smoking status, and age. We found a nonlinear pattern of association between exclusive breastfeeding duration and adiponectin in multivariate-adjusted models.
   CONCLUSIONS-In this prospective cohort study, we found a direct relationship between the duration of lactation and both ghrelin and PYY at 3 years postpartum. Diabetes 60:1277-1285, 2011
C1 [Stuebe, Alison M.] Univ N Carolina, Sch Med, Dept Obstet & Gynecol, Div Maternal Fetal Med, Chapel Hill, NC 27599 USA.
   [Stuebe, Alison M.] Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Maternal & Child Hlth, Chapel Hill, NC USA.
   [Mantzoros, Christos] Beth Israel Deaconess Med Ctr, Dept Endocrinol Diabet & Metab, Boston, MA 02215 USA.
   [Kleinman, Ken; Gillman, Matthew W.; Rifas-Shiman, Sheryl] Harvard Univ, Sch Med, Dept Populat Med, Obes Prevent Program,Harvard Pilgrim Hlth Care In, Boston, MA USA.
   [Gillman, Matthew W.] Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA.
   [Gunderson, Erica P.] Kaiser Permanente, Div Res, Epidemiol & Prevent Sect, Oakland, CA USA.
   [Rich-Edwards, Janet] Brigham & Womens Hosp, Connors Ctr Womens Hlth & Gender Biol, Boston, MA 02115 USA.
   [Rich-Edwards, Janet] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.
C3 University of North Carolina School of Medicine; University of North
   Carolina; University of North Carolina Chapel Hill; University of North
   Carolina; University of North Carolina Chapel Hill; Harvard University;
   Harvard University Medical Affiliates; Beth Israel Deaconess Medical
   Center; Harvard University; Harvard Medical School; Harvard Pilgrim
   Health Care; Harvard University; Harvard T.H. Chan School of Public
   Health; Kaiser Permanente; Harvard University; Harvard University
   Medical Affiliates; Brigham & Women's Hospital; Harvard University;
   Harvard T.H. Chan School of Public Health
RP Stuebe, AM (corresponding author), Univ N Carolina, Sch Med, Dept Obstet & Gynecol, Div Maternal Fetal Med, Chapel Hill, NC 27599 USA.
EM astuebe@med.unc.edu
RI Mantzoros, Christos/Y-2902-2019
OI Kleinman, Ken/0000-0002-5600-5834
FU National Institutes of Health [R21-DK-053539, R01-HD-034568,
   R01-HL-064925, R01-HL-075504, HD-5K12HD-050113-04]
FX This work was funded by National Institutes of Health grants
   R21-DK-053539, R01-HD-034568, R01-HL-064925, R01-HL-075504, and
   HD-5K12HD-050113-04 (to A.M.S.).
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NR 40
TC 39
Z9 47
U1 0
U2 12
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0012-1797
EI 1939-327X
J9 DIABETES
JI Diabetes
PD APR
PY 2011
VL 60
IS 4
BP 1277
EP 1285
DI 10.2337/db10-0637
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 749UK
UT WOS:000289496100023
PM 21350085
OA Green Published, Green Submitted, hybrid
DA 2025-06-11
ER

PT J
AU Ardiansyah
   Shirakawa, H
   Koseki, T
   Hashizume, K
   Komai, M
AF Ardiansyah
   Shirakawa, Hitoshi
   Koseki, Takuya
   Hashizume, Katsumi
   Komai, Michio
TI The Driselase-treated fraction of rice bran is a more effective dietary
   factor to improve hypertension, glucose and lipid metabolism in
   stroke-prone spontaneously hypertensive rats compared to ferulic acid
SO BRITISH JOURNAL OF NUTRITION
LA English
DT Article
DE rice bran; Driselase fraction; ferulic acid; blood pressure; glucose
   metabolism; lipid profile
ID ANGIOTENSIN-CONVERTING ENZYME; NITRIC-OXIDE PRODUCTION; VOLATILE
   FATTY-ACIDS; BLOOD-PRESSURE; INHIBITORY PEPTIDES; INSULIN-RESISTANCE;
   NUCLEAR RECEPTOR; OXIDATIVE STRESS; PLASMA-LIPIDS; WHITE RICE
AB The aim of this study is to investigate the effects of dietary supplementation with the Driselase-treated fraction (DF) of rice bran and ferulic acid (FA) on hypertension and glucose and lipid metabolism in stroke-prone spontaneously hypertensive rats (SHRSP). Male SHRSP at 4 weeks of age were divided into three groups, and for 8 weeks were fed (1) a control diet based on AIN-93M, (2) a DF of rice bran-supplemented diet at 60 g/kg and (3) an FA-supplemented diet at 0.01 a/kg. Means and standard errors were calculated and the data were tested by one-way ANOVA followed by a least significance difference test. The results showed that both the DF and FA diets significantly improved hypertension as well as glucose tolerance, plasma nitric oxide (NOx), urinary 8-hydroxy-2'-deoxyguanosine and other parameters. In particular, compared to the FA diet, the DF diet produced a significant improvement in urinary NOx, hepatic triacylglycerol and several mRNA expressions of metabolic parameters involved in glucose and lipid metabolisms. The results of the metabolic syndrome-related parameters obtained from this study suggest that the DF diet is more effective than the FA diet.
C1 Tohoku Univ, Grad Sch Agr Sci, Dept Sci Food Funct & Hlth, Lab Nutr, Sendai, Miyagi 980, Japan.
   NRIB, Hiroshima, Japan.
C3 Tohoku University
RP Ardiansyah (corresponding author), Tohoku Univ, Grad Sch Agr Sci, Dept Sci Food Funct & Hlth, Lab Nutr, Sendai, Miyagi 980, Japan.
EM ardy@biochem.tohoku.ac.jp
RI Shirakawa, Hitoshi/D-1406-2009; , Ardiansyah/AAI-8272-2020
OI SHIRAKAWA, HITOSHI/0000-0002-4828-5274; , Ardiansyah/0000-0003-2110-344X
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NR 56
TC 24
Z9 27
U1 0
U2 11
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1145
EI 1475-2662
J9 BRIT J NUTR
JI Br. J. Nutr.
PD JAN
PY 2007
VL 97
IS 1
BP 67
EP 76
DI 10.1017/S000711450721013X
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 135JA
UT WOS:000244148700010
PM 17217561
OA Bronze
DA 2025-06-11
ER

PT J
AU Krabbe, KS
   Reichenberg, A
   Yirmiya, R
   Smed, A
   Pedersen, BK
   Bruunsgaard, H
AF Krabbe, KS
   Reichenberg, A
   Yirmiya, R
   Smed, A
   Pedersen, BK
   Bruunsgaard, H
TI Low-dose endotoxemia and human neuropsychological functions
SO BRAIN BEHAVIOR AND IMMUNITY
LA English
DT Article
DE endotoxin; inflammation; cognitive function; cytokines
ID C-REACTIVE PROTEIN; BLOOD-CELL COUNT; PROLONGED EXERCISE;
   ALZHEIMERS-DISEASE; METABOLIC SYNDROME; HUMAN BRAIN; TNF-ALPHA; RISK;
   INFLAMMATION; CYTOKINES
AB Epidemiological data demonstrate an association between systemic low-grade inflammation defined as 2- to 3-fold increases in circulating inflammatory mediators and age-related decline in cognitive function. However, it is not known whether small elevations of circulating cytokine levels cause direct effects on human neuropsychological functions. We investigated changes in emotional, cognitive, and inflammatory parameters in an experimental in vivo model of low-grade inflammation. In a double-blind crossover study, 12 healthy young males completed neuropsychological tests before as well as 1.5, 6, and 24 h after an intravenous injection of Escherichia coli endotoxin (0.2 ng/kg) or saline in two experimental sessions. Endotoxin administration had no effect on body temperature, cortisol levels, blood pressure or heart rate, but circulating levels of tumor necrosis factor (TNF) and interleukin (IL)-6 increased 2- and Mold, respectively, reaching peak values at 3 h, whereas soluble TNF-receptors and IL-1 receptor antagonist peaked at 4.5 h. The neutrophil count increased and the lymphocyte count declined. In this model, low-dose endotoxemia did not affect cognitive performance significantly but declarative memory performance was inversely correlated with cytokine increases. In conclusion, our findings demonstrate a negative association between circulating IL-6 and memory functions during very low-dose endotoxemia independently of physical stress symptoms, and the hypothalamo-pituitary-adrenal axis. (c) 2005 Elsevier Inc. All rights reserved.
C1 Univ Copenhagen, Dept Infect Dis, Ctr Inflammat & Metab, Copenhagen, Denmark.
   Univ Copenhagen, Fac Hlth, Copenhagen Muscle Res Ctr, Rigshosp, Copenhagen, Denmark.
   Mt Sinai Sch Med, Dept Psychiat, New York, NY USA.
   Hebrew Univ Jerusalem, Dept Psychol, Jerusalem, Israel.
   Rigshosp, Neurol Clin, Copenhagen, Denmark.
C3 University of Copenhagen; University of Copenhagen; Copenhagen
   University Hospital; Rigshospitalet; Icahn School of Medicine at Mount
   Sinai; Hebrew University of Jerusalem; Rigshospitalet; University of
   Copenhagen; Copenhagen University Hospital
RP Univ Copenhagen, Dept Infect Dis, Ctr Inflammat & Metab, Copenhagen, Denmark.
EM karenkrabbe@dadlnet.dk
RI Reichenberg, Abraham/GQB-1227-2022; Pedersen, Bente/AGR-3217-2022;
   Bruunsgaard, Helle/AAY-3293-2020; Yirmiya, Raz/D-1090-2014
OI Yirmiya, Raz/0000-0002-4009-7316; Bruunsgaard,
   Helle/0000-0003-2330-0834; Pedersen, Bente Klarlund/0000-0001-6508-6288
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NR 43
TC 145
Z9 167
U1 0
U2 13
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0889-1591
EI 1090-2139
J9 BRAIN BEHAV IMMUN
JI Brain Behav. Immun.
PD SEP
PY 2005
VL 19
IS 5
BP 453
EP 460
DI 10.1016/j.bbi.2005.04.010
PG 8
WC Immunology; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Neurosciences & Neurology; Psychiatry
GA 956BZ
UT WOS:000231275200012
PM 15963684
DA 2025-06-11
ER

PT J
AU Gholami, A
   Amirkalali, B
   Hariri, M
AF Gholami, Ali
   Amirkalali, Bahareh
   Hariri, Mitra
TI Can soy isoflavones in combination with soy protein change serum levels
   of C-reactive protein among patients with chronic inflammatory diseases?
   A systematic review and meta-analysis on randomized controlled trials
SO JOURNAL OF HEALTH POPULATION AND NUTRITION
LA English
DT Review
DE C-reactive protein; Soy isoflavones; Soy protein; Systematic review;
   Meta-analysis
ID CARDIOVASCULAR-DISEASE; OXIDATIVE STRESS; POSTMENOPAUSAL WOMEN;
   ENDOTHELIAL FUNCTION; METABOLIC SYNDROME; MILK CONSUMPTION;
   BLOOD-PRESSURE; RISK-FACTORS; DOUBLE-BLIND; WHOLE SOY
AB Background C-reactive protein (CRP) is one of the most important markers for assessing inflammation status and its increased concentration in blood is associated with many chronic diseases in humans. The aim of this study was to reveal the effect of soy isoflavones containing soy protein on serum levels of CRP in adult population with chronic inflammatory diseases. Materials and methods We searched databases including PubMed, Cochrane Library, ISI Web of Science, Scopus, and clinicalTrials.gov up to March 2025. We used random effects model to calculate the heterogeneity and the overall effects. Results Twenty-seven articles were involved in the systematic review and twenty-two articles with thirty-four effect sizes were considered for meta-analysis. The overall estimates revealed that soy isoflavones containing soy protein significantly decreased serum levels of CRP in comparison with control group (weighted mean difference (WMD)= -0.49 mg/L; 95% confidence interval (CI): -0.74, -0.25; P = 0 < 0.001). Conclusion Although our results clearly showed soy isoflavones containing soy protein can have decreasing effect on inflammation in participants with chronic inflammatory disease, more large-scale and high quality interventional studies still need to be done to clarify our results.
C1 [Gholami, Ali; Hariri, Mitra] Neyshabur Univ Med Sci, Noncommunicable Dis Res Ctr, Neyshabur, Iran.
   [Gholami, Ali] Neyshabur Univ Med Sci, Workplace Hlth Res Ctr, Neyshabur, Iran.
   [Amirkalali, Bahareh] Iran Univ Med Sci, Gastrointestinal & Liver Dis Res Ctr, Tehran, Iran.
   [Hariri, Mitra] Neyshabur Univ Med Sci, Hlth Ageing Res Ctr, Neyshabur, Iran.
C3 Iran University of Medical Sciences
RP Hariri, M (corresponding author), Neyshabur Univ Med Sci, Noncommunicable Dis Res Ctr, Neyshabur, Iran.; Hariri, M (corresponding author), Neyshabur Univ Med Sci, Hlth Ageing Res Ctr, Neyshabur, Iran.
EM Haririm1@nums.ac.ir
RI Gholami, Ali/I-1626-2018
FU Neyshabur University of Medical Sciences
FX The research leading to these results has received funding from
   Neyshabur University of Medical Sciences.
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NR 64
TC 0
Z9 0
U1 0
U2 0
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1606-0997
EI 2072-1315
J9 J HEALTH POPUL NUTR
JI J. Heatlh Popul. Nutr.
PD MAY 12
PY 2025
VL 44
IS 1
AR 154
DI 10.1186/s41043-025-00902-6
PG 17
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA 2XQ7M
UT WOS:001493767100001
PM 40355968
DA 2025-06-11
ER

PT J
AU Serio, F
   Imbriani, G
   Acito, M
   Moretti, M
   Fanizzi, FP
   De Donno, A
   Valacchi, G
AF Serio, Francesca
   Imbriani, Giovanni
   Acito, Mattia
   Moretti, Massimo
   Fanizzi, Francesco Paolo
   De Donno, Antonella
   Valacchi, Giuseppe
TI Moderate red wine intake and cardiovascular health protection: a
   literature review
SO FOOD & FUNCTION
LA English
DT Review
ID ALCOHOL-CONSUMPTION; METABOLIC SYNDROME; OXIDATIVE STRESS;
   PROSTATE-CANCER; BLOOD-PRESSURE; LIPID PROFILE; IN-VITRO; RESVERATROL;
   RISK; POLYPHENOLS
AB Wine is a complex matrix consisting primarily of water (86%) and ethyl alcohol (12%), as well as other different molecules, such as polyphenols, organic acids, tannins, compound minerals, vitamins and biologically active compounds which play an important role in the specific characteristics of each wine. According to the Dietary Guidelines for Americans 2015-2020, moderate red wine consumption-defined as up to two units of alcohol per day for men and up to one unit of alcohol per day for women-significantly reduces the risk of cardiovascular disease which represents the major causes of mortality, and disability, in developed countries. We reviewed the available literature concerning the potential relationship between moderate red wine consumption and cardiovascular health. We searched Medline, Scopus and Web of Science (WOS) for randomized controlled studies and case-control studies published from 2002 to 2022. A total of 27 articles were selected for the review. According to epidemiological evidence, drinking red wine in moderation lowers the risk of developing cardiovascular disease and diabetes. Red wine contains both alcoholic and non-alcoholic ingredients; however, it is yet unclear which is to blame for these effects. Combining wine with the diet of healthy individuals may add additional benefits. New studies should focus more on the characterization of the individual components of wine, to allow the analysis and study of the impact of each of them on the prevention and treatment of certain diseases.
C1 [Serio, Francesca; Imbriani, Giovanni; Fanizzi, Francesco Paolo; De Donno, Antonella] Univ Salento, Dept Biol & Environm Sci & Technol, I-73100 Lecce, Italy.
   [Acito, Mattia; Moretti, Massimo] Univ Perugia, Dept Pharmaceut Sci, Unit Publ Hlth, I-06122 Perugia, Italy.
   [Valacchi, Giuseppe] Univ Ferrara, Dept Environm & Prevent Sci, I-44121 Ferrara, Italy.
   [Valacchi, Giuseppe] North Carolina State Univ, Plants Human Hlth Inst, Kannapolis, NC 28081 USA.
C3 University of Salento; University of Perugia; University of Ferrara;
   North Carolina State University
RP Serio, F (corresponding author), Univ Salento, Dept Biol & Environm Sci & Technol, I-73100 Lecce, Italy.; Valacchi, G (corresponding author), Univ Ferrara, Dept Environm & Prevent Sci, I-44121 Ferrara, Italy.; Valacchi, G (corresponding author), North Carolina State Univ, Plants Human Hlth Inst, Kannapolis, NC 28081 USA.
EM francesca.serio@unisalento.it; vlcgpp@unife.it
RI Serio, Francesca/AAR-2943-2020; Acito, Mattia/AAC-3772-2020; Fanizzi,
   Francesco Paolo/K-5766-2012; Moretti, Massimo/H-6885-2017
OI Fanizzi, Francesco Paolo/0000-0003-3073-5772; Moretti,
   Massimo/0000-0002-5038-8619; Acito, Mattia/0000-0003-1808-1999
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NR 132
TC 15
Z9 15
U1 1
U2 32
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PD JUL 17
PY 2023
VL 14
IS 14
BP 6346
EP 6362
DI 10.1039/d3fo01004j
EA JUN 2023
PG 17
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA L7VM5
UT WOS:001023684800001
PM 37403999
DA 2025-06-11
ER

PT J
AU Ishak, NSM
   Ikemoto, K
AF Mohamad Ishak, Nur Syafiqah
   Ikemoto, Kazuto
TI Pyrroloquinoline-quinone to reduce fat accumulation and ameliorate
   obesity progression
SO FRONTIERS IN MOLECULAR BIOSCIENCES
LA English
DT Review
DE PQQ; pyrroloquinoline quinone; fat; obesity; lipogenesis; mitochondria;
   inflammation; metabolic syndrome
ID MITOCHONDRIAL BIOGENESIS; OXIDATIVE STRESS; INFLAMMATION; PQQ;
   COACTIVATOR; ANTIOXIDANT; MANAGEMENT; PROGRAMS; ALPHA
AB Obesity is a major health concern worldwide, and its prevalence continues to increase in several countries. Pyrroloquinoline quinone (PQQ) is naturally found in some foods and is available as a dietary supplement in its disodium crystal form. The potential health benefits of PQQ have been studied, considering its antioxidant and anti-inflammatory properties. Furthermore, PQQ has been demonstrated to significantly influence the functions of mitochondria, the organelles responsible for energy production within cells, and their dysfunction is associated with various health conditions, including obesity complications. Here, we explore PQQ properties that can be exploited in obesity treatment and highlight the underlying molecular mechanisms. We review animal and cell culture studies demonstrating that PQQ is beneficial for reducing the accumulation of visceral and hepatic fat. In addition to inhibiting lipogenesis, PQQ can increase mitochondria number and function, leading to improved lipid metabolism. Besides diet-induced obesity, PQQ ameliorates programing obesity of the offspring through maternal supplementation and alters gut microbiota, which reduces obesity risk. In obesity progression, PQQ mitigates mitochondrial dysfunction and obesity-associated inflammation, resulting in the amelioration of the progression of obesity co-morbidities, including non-alcoholic fatty liver disease, chronic kidney disease, and Type 2 diabetes. Overall, PQQ has great potential as an anti-obesity and preventive agent for obesity-related complications. Although human studies are still lacking, further investigations to address obesity and associated disorders are still warranted.
C1 [Mohamad Ishak, Nur Syafiqah; Ikemoto, Kazuto] Mitsubishi Gas Chem Co Inc, Niigata Res Lab, Niigata, Japan.
RP Ikemoto, K (corresponding author), Mitsubishi Gas Chem Co Inc, Niigata Res Lab, Niigata, Japan.
EM kazuto-ikemoto@mgc.co.jp
OI Mohamad Ishak, Nur Syafiqah/0000-0002-7818-428X
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NR 65
TC 13
Z9 13
U1 6
U2 47
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 2296-889X
J9 FRONT MOL BIOSCI
JI Front. Mol. Biosci.
PD MAY 5
PY 2023
VL 10
AR 1200025
DI 10.3389/fmolb.2023.1200025
PG 8
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA G9HD2
UT WOS:000992171700001
PM 37214340
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Chavushyan, VA
   Simonyan, K
   Danielyan, MH
   Avetisyan, LG
   Darbinyan, L
   Isoyan, AS
   Lorikyan, AG
   Hovhannisyan, LE
   Babakhanyan, MA
   Sukiasyan, LM
AF Chavushyan, V. A.
   Simonyan, K., V
   Danielyan, M. H.
   Avetisyan, L. G.
   Darbinyan, L., V
   Isoyan, A. S.
   Lorikyan, A. G.
   Hovhannisyan, L. E.
   Babakhanyan, M. A.
   Sukiasyan, L. M.
TI Pathology and prevention of brain microvascular and neuronal dysfunction
   induced by a high-fructose diet in rats
SO METABOLIC BRAIN DISEASE
LA English
DT Article
DE Fructose; Acetylcholinesterase inhibitor; Prefrontal cortex;
   Microvascular; Short-term plasticity
ID ALZHEIMERS-DISEASE; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   GANODERMA-LUCIDUM; OXIDATIVE STRESS; BLOOD-FLOW;
   CHOLINESTERASE-INHIBITORS; CHOLINERGIC SYSTEM; STEVIA-REBAUDIANA;
   RISK-FACTOR
AB A high-fructose diet causes metabolic abnormalities in rats, and the cluster of complications points to microvascular and neuronal disorders of the brain. The aim of this study was to evaluate i) the involvement of microvascular disorders and neuronal plasticity in the deleterious effects of a high-fructose diet on the rat brain and ii) a comparative assessment of the effectiveness of Phytocollection therapy (with antidiabetic, antioxidant, and acetylcholinesterase inhibitory activities) compared to Galantamine as first-line therapy for dementia and Diabeton as first-line therapy for hyperglycemia. The calcium adenosine triphosphate non-injection histoangiological method was used to assess capillary network diameter and density. A high-fructose diet resulted in a significant decrease in the diameter and density of the capillary bed, and pharmacological manipulations had a modulatory effect on microcirculatory adaptive mechanisms. In vivo single-unit extracellular recording was used to investigate short-term plasticity in the medial prefrontal cortex. Differences in the parameters of spike background activity and expression of excitatory and inhibitory responses of cortical neurons have been discovered, allowing for flexibility and neuronal function stabilization in pathology and pharmacological prevention. Integration of the coupling mechanism between microvascular function and neuronal spike activity could delay the progressive decline in cognitive function in rats fed a high fructose diet.
C1 [Chavushyan, V. A.; Simonyan, K., V; Avetisyan, L. G.; Isoyan, A. S.; Lorikyan, A. G.; Sukiasyan, L. M.] Orbeli Inst Physiol NAS RA, Neuroendocrine Relationships Lab, Yerevan 0028, Armenia.
   [Danielyan, M. H.] Orbeli Inst Physiol NAS RA, Histochem & Electron Microscopy Lab, Yerevan 0028, Armenia.
   [Darbinyan, L., V] Orbeli Inst Physiol NAS RA, Sensorimotor Integrat Lab, Yerevan 0028, Armenia.
   [Hovhannisyan, L. E.; Babakhanyan, M. A.] GS Davtyan Inst Hydropon Problems NAS RA, Yerevan 0082, Armenia.
   [Sukiasyan, L. M.] Yerevan State Med Univ M Heratsi, Yerevan 0025, Armenia.
C3 National Academy of Sciences of Armenia; Institute of Physiology after
   L.A. Orbeli - NAS RA; National Academy of Sciences of Armenia; Institute
   of Physiology after L.A. Orbeli - NAS RA; National Academy of Sciences
   of Armenia; Institute of Physiology after L.A. Orbeli - NAS RA; Yerevan
   State Medical University
RP Simonyan, K (corresponding author), Orbeli Inst Physiol NAS RA, Neuroendocrine Relationships Lab, Yerevan 0028, Armenia.
RI Simonyan, Karen/GXA-2514-2022; Darbinyan, Lilit/JNA-2072-2023;
   Avetisyan, Lyudmila/JTT-5747-2023; Danielyan, Margarita/GQB-3551-2022
OI Darbinyan, Lilit/0000-0002-5364-2838; Danielyan,
   Margarita/0000-0001-8334-7066; Hovhannisyan, Lusya/0000-0002-1572-1180
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NR 120
TC 1
Z9 1
U1 1
U2 10
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0885-7490
EI 1573-7365
J9 METAB BRAIN DIS
JI Metab. Brain Dis.
PD JAN
PY 2023
VL 38
IS 1
BP 269
EP 286
DI 10.1007/s11011-022-01098-y
EA OCT 2022
PG 18
WC Endocrinology & Metabolism; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology
GA 7V0QL
UT WOS:000871164900001
PM 36271967
DA 2025-06-11
ER

PT J
AU Scharf, P
   Rizzetto, F
   Xavier, LF
   Farsky, SHP
AF Scharf, Pablo
   Rizzetto, Felipe
   Xavier, Luana Filippi
   Poliselli Farsky, Sandra Helena
TI Xenobiotics Delivered by Electronic Nicotine Delivery Systems: Potential
   Cellular and Molecular Mechanisms on the Pathogenesis of Chronic Kidney
   Disease
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE diabetes mellitus; hypertension; nicotine; risk assessment; flavoring
   agents; volatiles organic compounds; cigarette smoking; ENDS
ID ISCHEMIA-REPERFUSION INJURY; CIGARETTE-SMOKING; ULTRAFINE PARTICLES;
   OXIDATIVE STRESS; ACETYLCHOLINE-RECEPTORS; HPA AXIS;
   DIABETIC-NEPHROPATHY; GLUCOSE-HOMEOSTASIS; CARBONYL-COMPOUNDS; METABOLIC
   SYNDROME
AB Chronic kidney disease (CKD) is characterized as sustained damage to the renal parenchyma, leading to impaired renal functions and gradually progressing to end-stage renal disease (ESRD). Diabetes mellitus (DM) and arterial hypertension (AH) are underlying diseases of CKD. Genetic background, lifestyle, and xenobiotic exposures can favor CKD onset and trigger its underlying diseases. Cigarette smoking (CS) is a known modified risk factor for CKD. Compounds from tobacco combustion act through multi-mediated mechanisms that impair renal function. Electronic nicotine delivery systems (ENDS) consumption, such as e-cigarettes and heated tobacco devices, is growing worldwide. ENDS release mainly nicotine, humectants, and flavorings, which generate several byproducts when heated, including volatile organic compounds and ultrafine particles. The toxicity assessment of these products is emerging in human and experimental studies, but data are yet incipient to achieve truthful conclusions about their safety. To build up the knowledge about the effect of currently employed ENDS on the pathogenesis of CKD, cellular and molecular mechanisms of ENDS xenobiotic on DM, AH, and kidney functions were reviewed. Unraveling the toxic mechanisms of action and endpoints of ENDS exposures will contribute to the risk assessment and implementation of proper health and regulatory interventions.
C1 [Scharf, Pablo; Rizzetto, Felipe; Xavier, Luana Filippi; Poliselli Farsky, Sandra Helena] Univ Sao Paulo, Sch Pharmaceut Sci, Dept Clin & Toxicol Anal, BR-05508220 Sao Paulo, Brazil.
C3 Universidade de Sao Paulo
RP Farsky, SHP (corresponding author), Univ Sao Paulo, Sch Pharmaceut Sci, Dept Clin & Toxicol Anal, BR-05508220 Sao Paulo, Brazil.
EM sfarsky@usp.br
RI Scharf, Pablo/HHC-3579-2022; Farsky, Sandra/C-4044-2012
OI Filippi Xavier, Luana/0000-0002-1752-181X
FU Fundacao de Amparo a Pesquisa do Estado de Sao Paulo, Brazil (FAPESP)
   [2019/19573-7, 2020/14368-3]; Conselho Nacional de Desenvolvimento
   Cientifico e Tecnologico, Brazil (CNPq); Coordenacao de Aperfeicoamento
   de Pessoal de Nivel Superior; CAPES; FAPESP [2019/19573-7]
FX This research was funded by Fundacao de Amparo a Pesquisa do Estado de
   Sao Paulo, Brazil (FAPESP; grant 2019/19573-7-S.H.P.F.; grant
   2020/14368-3-P.S.) and the Conselho Nacional de Desenvolvimento
   Cientifico e Tecnologico, Brazil (CNPq) for the Researcher fellow to
   S.H.P.F, and L.F.X. F.R. is a pos-doctoral fellow (Coordenacao de
   Aperfeicoamento de Pessoal de Nivel Superior; CAPES). The APC was funded
   by FAPESP (grant 2019/19573-7-S.H.P.F).
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NR 181
TC 5
Z9 6
U1 3
U2 18
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD SEP
PY 2022
VL 23
IS 18
AR 10293
DI 10.3390/ijms231810293
PG 18
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 4Q9JE
UT WOS:000856390000001
PM 36142207
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Mahmudiono, T
   Khaydarov, NK
   Jasim, SA
   Hammid, AT
   Failoc-Rojas, VE
   Shalaby, MN
   Jannat, B
   Nouri, M
   Fadel, A
AF Mahmudiono, Trias
   Khaydarov, Nodirjon Kadirovich
   Jasim, Saade Abdalkareem
   Hammid, Ali Thaeer
   Failoc-Rojas, Virgilio E.
   Shalaby, Mohammed Nader
   Jannat, Behrooz
   Nouri, Mehran
   Fadel, Abdulmnannan
TI Systematic review and meta-analysis of randomized, controlled trials on
   the effects of soy and soy products supplementation on serum adiponectin
   levels
SO DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS
LA English
DT Review
DE Soy; Adipokines; Adiponectin; Systematic review; Meta-analysis
ID HIGH-DOSE ISOFLAVONES; INFLAMMATORY MARKERS; POSTMENOPAUSAL WOMEN;
   METABOLIC SYNDROME; OXIDATIVE STRESS; BLOOD-PRESSURE; OBESITY;
   CONSUMPTION; ADIPOKINES; PARAMETERS
AB Background and aims: Our aim in this meta-analysis was to determine the effect of soy and soy product supplementation on serum adiponectin levels. Method: A systematic search was conducted using Medline (PubMed and Web of Science), Scopus, and Cochrane Library for eligible trials up to August 2020. A random-effects model was used to pool calculated effect sizes. Results: Seven trials were included in the overall analysis. Our analysis showed that soy and soy product supplementation did not significantly affect adiponectin concentrations (WMD =-0.77 mg/ml, 95% CI:-0.61, 2.15, P = 0.27) in comparison with a placebo. The between-study heterogeneity was high (I-2: 68.2%, P = 0.004). Subgroup analysis, based on participants' health status and duration of the supple-mentation, could not detect the potential source of the observed heterogeneity. In addition, subgroup analysis showed that the effect was not statistically significant in all subgroups. Conclusion: Overall, soy and soy product supplementation did not change the circulatory adiponectin levels. In addition, the results were not affected by the participant's health status and duration of sup-plementation. However, further studies are needed to confirm the present results. (c) 2022 Diabetes India. Published by Elsevier Ltd. All rights reserved.
C1 [Mahmudiono, Trias] Univ Airlangga, Fac Publ Hlth, Dept Nutr, Surabaya, Indonesia.
   [Khaydarov, Nodirjon Kadirovich] Tashkent State Dent Inst, Makhtumkuli St 103, Tashkent 100047, Uzbekistan.
   [Jasim, Saade Abdalkareem] Al maarif Univ Coll, Med Lab Tech Dept, Al Anbar Ramadi, Iraq.
   [Hammid, Ali Thaeer] Imam Jaafar Al Sadiq Univ, Fac Informat Technol, Comp Engn Tech Dept, UK, Baghdad, Iraq.
   [Failoc-Rojas, Virgilio E.] Univ Privada Norbert Wiener, Med Basada Evidencia, Lima, Peru.
   [Shalaby, Mohammed Nader] Suez Canal Univ, Fac Phys Educ, Biol Sci & Sports Hlth Dept, Ismailia, Egypt.
   [Jannat, Behrooz] Minist Hlth & Med Educ, FDA, Halal Res Ctr IRI, Tehran, Iran.
   [Nouri, Mehran] Shiraz Univ Med Sci, Sch Nutr & Food Sci, Dept Community Nutr, Shiraz, Iran.
   [Nouri, Mehran] Shiraz Univ Med Sci, Res Comm, Shiraz, Iran.
   [Fadel, Abdulmnannan] Liverpool John Moores Univ, Sch Sport & Exercise Sci, Liverpool, Lancashire, England.
C3 Airlangga University; Al-Maarif University; Imam Jaa'far al-Sadiq
   University; Universidad Norbert Wiener; Egyptian Knowledge Bank (EKB);
   Suez Canal University; Ministry of Health & Medical Education (MOHME);
   Shiraz University of Medical Science; Shiraz University of Medical
   Science; Liverpool John Moores University
RP Nouri, M (corresponding author), Shiraz Univ Med Sci, Sch Nutr & Food Sci, Dept Community Nutr, Shiraz, Iran.; Nouri, M (corresponding author), Shiraz Univ Med Sci, Res Comm, Shiraz, Iran.
EM mehran_nouri71@yahoo.com
RI Mahmudiono, Trias/I-4020-2019; jannat, behrooz/ABA-2337-2020; Fadel,
   Abdulmannan/AAS-8620-2021; Khaydarov, Nodir/JOK-0393-2023; Failoc-Rojas,
   Virgilio/AAD-8668-2019; Abdalkareem, saade/F-1943-2019; Shalaby,
   Mohammed Nader/C-5576-2016
OI Abdalkareem Jasim, Saade/0009-0007-8087-809X; Abdalkareem,
   saade/0000-0001-5201-9844; Fadel, Abdulmannan/0000-0001-6042-8939;
   Abdalkareem Jasim, Saade/0009-0007-5178-6399; Shalaby, Mohammed
   Nader/0000-0002-0228-3003; jannat, behrooz/0000-0001-9208-2709
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NR 44
TC 1
Z9 1
U1 0
U2 2
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1871-4021
EI 1878-0334
J9 DIAB MET SYND CLIN R
JI DIABET. METAB. SYNDR. CLIN. RES. REV.
PD SEP
PY 2022
VL 16
IS 9
AR 102558
DI 10.1016/j.dsx.2022.102558
EA JUL 2022
PG 6
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA 5J8NG
UT WOS:000869293500005
PM 35803164
OA Green Accepted, Green Published
DA 2025-06-11
ER

PT J
AU Golikov, MV
   Karpenko, IL
   Lipatova, AV
   Ivanova, ON
   Fedyakina, IT
   Larichev, VF
   Zakirova, NF
   Leonova, OG
   Popenko, VI
   Bartosch, B
   Kochetkov, SN
   Smirnova, OA
   Ivanov, AV
AF Golikov, Michail V.
   Karpenko, Inna L.
   Lipatova, Anastasiya V.
   Ivanova, Olga N.
   Fedyakina, Irina T.
   Larichev, Viktor F.
   Zakirova, Natalia F.
   Leonova, Olga G.
   Popenko, Vladimir I.
   Bartosch, Birke
   Kochetkov, Sergey N.
   Smirnova, Olga A.
   Ivanov, Alexander V.
TI Cultivation of Cells in a Physiological Plasmax Medium Increases
   Mitochondrial Respiratory Capacity and Reduces Replication Levels of RNA
   Viruses
SO ANTIOXIDANTS
LA English
DT Article
DE culture medium; Plasmax; serine biosynthesis; respiration; glycolysis;
   mitochondrial network; hepatitis C virus; influenza virus; SARS-CoV-2;
   reactive oxygen species
ID HEPATITIS-C VIRUS; CYSTINE ACCUMULATION; OXIDATIVE STRESS; METABOLISM;
   MECHANISMS; INFECTION; ACID; NRF2
AB Changes in metabolic pathways are often associated with the development of various pathologies including cancer, inflammatory diseases, obesity and metabolic syndrome. Identification of the particular metabolic events that are dysregulated may yield strategies for pharmacologic intervention. However, such studies are hampered by the use of classic cell media that do not reflect the metabolite composition that exists in blood plasma and which cause non-physiological adaptations in cultured cells. In recent years two groups presented media that aim to reflect the composition of human plasma, namely human plasma-like medium (HPLM) and Plasmax. Here we describe that, in four different mammalian cell lines, Plasmax enhances mitochondrial respiration. This is associated with the formation of vast mitochondrial networks and enhanced production of reactive oxygen species (ROS). Interestingly, cells cultivated in Plasmax displayed significantly less lysosomes than when any standard media were used. Finally, cells cultivated in Plasmax support replication of various RNA viruses, such as hepatitis C virus (HCV) influenza A virus (IAV), severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) and several others, albeit at lower levels and with delayed kinetics. In conclusion, studies of metabolism in the context of viral infections, especially those concerning mitochondria, lysosomes, or redox systems, should be performed in Plasmax medium.
C1 [Golikov, Michail V.; Karpenko, Inna L.; Lipatova, Anastasiya V.; Ivanova, Olga N.; Zakirova, Natalia F.; Leonova, Olga G.; Popenko, Vladimir I.; Kochetkov, Sergey N.; Smirnova, Olga A.; Ivanov, Alexander V.] Russian Acad Sci, Engelhardt Inst Mol Biol, Moscow 119991, Russia.
   [Fedyakina, Irina T.; Larichev, Viktor F.] Minist Russia, Gamaleya Natl Res Ctr Epidemiol & Microbiol, Moscow 132098, Russia.
   [Bartosch, Birke] Univ Lyon, INSERM, U1052, Canc Res Ctr Lyon, F-69000 Lyon, France.
C3 Russian Academy of Sciences; Engelhardt Institute of Molecular Biology,
   RAS; Russian Academy of Medical Sciences; Gamaleya National Research
   Center for Epidemiology & Microbiology, RAMS; Institut National de la
   Sante et de la Recherche Medicale (Inserm); Universite Claude Bernard
   Lyon 1; UNICANCER; Centre Leon Berard
RP Smirnova, OA; Ivanov, AV (corresponding author), Russian Acad Sci, Engelhardt Inst Mol Biol, Moscow 119991, Russia.
EM cool.mik3492594@yandex.ru; ilkzkil@gmail.com; lipatovaanv@gmail.com;
   olgaum@yandex.ru; irfed2@mail.ru; vlaritchev@mail.ru;
   nat_zakirova@mail.ru; leonova-kozma@mail.ru; popenko@eimb.ru;
   birke.bartosch@inserm.fr; snk1952@gmail.com; o.smirnova.imb@gmail.com;
   aivanov@yandex.ru
RI Zakirova, Natalia/AAD-1838-2020; Smirnova, Olga/G-2612-2015; Karpenko,
   Inna/AAU-6370-2021; Kochetkov, Sergey/O-1065-2013; Larichev,
   Victor/HHZ-3732-2022; Ivanova, Olga/J-5667-2015; Bartosch,
   Birke/I-7255-2018; Ivanov, Alexander/A-7700-2012
OI Ivanova, Olga/0000-0002-3673-4714; Bartosch, Birke/0000-0001-6354-4660;
   Lipatova, Anastasia/0000-0003-4501-8514; Ivanov,
   Alexander/0000-0002-5659-9679
FU Russian science foundation [19-74-10086, 19-14-00197]; Russian Science
   Foundation [19-74-10086, 19-14-00197] Funding Source: Russian Science
   Foundation
FX FundingImpact of Plasmax medium on cell metabolism was supported by
   Russian science foundation (grant #19-74-10086), whereas experiment with
   infectious models were funded within grant #19-14-00197.
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NR 66
TC 31
Z9 32
U1 0
U2 7
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD JAN
PY 2022
VL 11
IS 1
AR 97
DI 10.3390/antiox11010097
PG 19
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA YN4SI
UT WOS:000747249900001
PM 35052601
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Cruz, PL
   Moraes-Silva, IC
   Ribeiro, AA
   Machi, JF
   de Melo, MDT
   dos Santos, F
   da Silva, MB
   Strunz, CMC
   Caldini, EG
   Irigoyen, MC
AF Cruz, Paula L.
   Moraes-Silva, Ivana C.
   Ribeiro, Amanda A.
   Machi, Jacqueline F.
   de Melo, Marcelo Dantas Tavares
   dos Santos, Fernando
   da Silva, Maikon Barbosa
   Strunz, Celia Maria Cassaro
   Caldini, Elia Garcia
   Irigoyen, Maria-Claudia
TI Nicotinamide attenuates streptozotocin-induced diabetes complications
   and increases survival rate in rats: role of autonomic nervous system
SO BMC ENDOCRINE DISORDERS
LA English
DT Article
DE Nicotinamide; Diabetes; Autonomic nervous system
ID METABOLIC SYNDROME; MYOCARDIAL-INFARCTION; OXIDATIVE STRESS;
   PARASYMPATHETIC DYSFUNCTION; INSULIN-SECRETION; MODEL; IMPAIRMENT;
   PARAMETERS; RESISTANCE; PRESSURE
AB Background To evaluate the effect of nicotinamide prior to streptozotocin-induced (STZ) diabetes in baroreflex sensitivity and cardiovascular autonomic modulation, and its association with hemodynamics and metabolic parameters. Methods Methods: Male Wistar rats were divided into control (Cont) and STZ-induced diabetes (Diab). Half of the rats from each group received a single dose of nicotinamide (100 mg/Kg) before STZ injection (Cont+NicA and Diab+NicA). All groups were followed-up for 5 weeks. Results Body weight loss of more than 40% was observed in Diab throughout the period (Diab: 271.00 +/- 12.74 g; Diab+NicA: 344.62 +/- 17.82). Increased glycemia was seen in Diab rats (541.28 +/- 18.68 mg/dl) while Diab+NicA group had a slight decrease (440.87 +/- 20.96 mg/dl). However, insulin resistance was observed only in Diab. In relation to Cont, heart rate, mean blood pressure and diastolic function were reduced when compared to Diab, together with parasympathetic modulation and baroreflex sensitivity. All of these parameters were improved in Diab+NicA when compared to Diab. Improved baroreflex sensitivity and parasympathetic modulation were correlated with glycemia, insulin resistance, and body weight mass. Additionally, Diab+NicA group increased survival rate. Conclusions Results suggest that the association of nicotinamide in STZ-induced diabetic rats prevents most of the expected derangements mainly by preserving parasympathetic and baroreflex parameters.
C1 [Cruz, Paula L.; Moraes-Silva, Ivana C.; Ribeiro, Amanda A.; Machi, Jacqueline F.; de Melo, Marcelo Dantas Tavares; dos Santos, Fernando; da Silva, Maikon Barbosa; Strunz, Celia Maria Cassaro; Irigoyen, Maria-Claudia] Univ Sao Paulo, Sch Med, Heart Inst InCor, Av Dr Eneas Carvalho Aguiar,44 Bloco 1, BR-05403900 Sao Paulo, SP, Brazil.
   [Caldini, Elia Garcia] Univ Sao Paulo, Sch Med, Dept Pathol, Sao Paulo, Brazil.
C3 Universidade de Sao Paulo; Universidade de Sao Paulo
RP Irigoyen, MC (corresponding author), Univ Sao Paulo, Sch Med, Heart Inst InCor, Av Dr Eneas Carvalho Aguiar,44 Bloco 1, BR-05403900 Sao Paulo, SP, Brazil.
EM hipirigoyen@gmail.com
RI dos'Santos, Fernando/LUY-1291-2024; Moraes-Silva, Ivana/K-2557-2019;
   MELO, MARCELO/AGO-0900-2022; Irigoyen, maria Claudia/N-6880-2014;
   Caldini, Elia Garcia/F-1105-2011; Strunz, Celia/G-5562-2011
OI Cruz, Paula Lazara/0000-0001-9917-9570; Irigoyen, maria
   Claudia/0000-0003-2097-3662; Caldini, Elia Garcia/0000-0001-5322-3812;
   dos Santos, Fernando/0000-0002-9147-5137; Strunz,
   Celia/0000-0002-9766-1184
FU Fundacao de Amparo a Pesquisa do Estado de Sao Paulo [FAPESP
   2012/20262-7]; Conselho Nacional de Pesquisa, Brazil [CNPq
   307138/2015-1]
FX This work was supported by Fundacao de Amparo a Pesquisa do Estado de
   Sao Paulo (FAPESP 2012/20262-7) and Conselho Nacional de Pesquisa (CNPq
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NR 48
TC 37
Z9 38
U1 0
U2 6
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1472-6823
J9 BMC ENDOCR DISORD
JI BMC Endocr. Disord.
PD JUN 28
PY 2021
VL 21
IS 1
AR 133
DI 10.1186/s12902-021-00795-6
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA TD8GN
UT WOS:000669558300002
PM 34182970
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Lelis, DD
   Andrade, JMO
   Almenara, CCP
   Broseguini, GB
   Mill, JG
   Baldo, MP
AF Lelis, Deborah de Farias
   Oliveira Andrade, Joao Marcus
   Pereira Almenara, Camila Cruz
   Broseguini-Filho, Gilson B.
   Mill, Jose Geraldo
   Baldo, Marcelo Perim
TI High fructose intake and the route towards cardiometabolic diseases
SO LIFE SCIENCES
LA English
DT Review
DE Fructose; Obesity; Metabolic disorders; Hypertension; Cardiovascular
   diseases
ID SWEETENED BEVERAGE CONSUMPTION; INDUCED INSULIN-RESISTANCE; INDUCED
   METABOLIC SYNDROME; RENIN-ANGIOTENSIN SYSTEM; SOFT DRINK CONSUMPTION;
   FATTY LIVER-DISEASE; CORN SYRUP; ADIPOSE-TISSUE; OXIDATIVE STRESS;
   ENDOTHELIAL DYSFUNCTION
AB It is known that dietary habits have a strong influence on body metabolism. In the last decades, the dietary habits have changed worldwide, and the consumption of fructose, especially in sugar-sweetened beverages, increased significantly. In this perspective, the present review aimed to summarize the effects of fructose on different cardiometabolic conditions. Clinical, experimental, and epidemiological studies evidenced that fructose can exert several deleterious effects when its consumption is above the recommended amounts. The increased fructose consumption decreases satiety, favoring a positive energy balance, increases adipogenesis, leading to visceral fat accumulation, induces ectopic fat accumulation, especially in the skeletal muscle and liver, leading to insulin resistance, inflammation, and lipid metabolism impairment, increases arterial blood pressure and causes vascular damage. Therefore, increased fructose consumption is linked to the development of alarming cardio-metabolic conditions, such as obesity, insulin resistance, type 2 diabetes, non-alcoholic fatty liver disease, and cardiovascular diseases, through several different mechanisms. Further clinical and experimental studies are still necessary to elucidate additional signaling pathways and mechanisms by which fructose is involved in all the mentioned cardiometabolic disorders. Also, the reported findings raise the need for the creation of public health policies aimed to prevent diet-associated cardiometabolic disorders, thus improving the population quality of life.
C1 [Lelis, Deborah de Farias; Oliveira Andrade, Joao Marcus; Baldo, Marcelo Perim] Montes Claros State Univ, Postgrad Program Hlth Sci, BR-39401089 Montes Claros, MG, Brazil.
   [Pereira Almenara, Camila Cruz; Broseguini-Filho, Gilson B.; Mill, Jose Geraldo] Univ Fed Espirito Santo, Dept Physiol Sci, BR-27042755 Vitoria, ES, Brazil.
   [Baldo, Marcelo Perim] Ctr Univ UNIFIPMOC, Dept Med, BR-39401089 Montes Claros, MG, Brazil.
   [Baldo, Marcelo Perim] Montes Claros State Univ, Dept Pathophysiol, BR-39401089 Montes Claros, MG, Brazil.
C3 Universidade Federal do Espirito Santo
RP Baldo, MP (corresponding author), Monies Claros State Univ UNIMONTES, Dept Pathophysiol, Av Dr Rui Braga S-N, BR-39401089 Montes Claros, MG, Brazil.
EM marcelobaldo@ymail.com
RI Baldo, Marcelo/G-6994-2012; Andrade, Joao/K-4072-2015
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NR 175
TC 30
Z9 31
U1 2
U2 37
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0024-3205
EI 1879-0631
J9 LIFE SCI
JI Life Sci.
PD OCT 15
PY 2020
VL 259
AR 118235
DI 10.1016/j.lfs.2020.118235
PG 13
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA OH3CI
UT WOS:000582445600003
PM 32800834
DA 2025-06-11
ER

PT J
AU Tarragon, E
   Moreno, JJ
AF Tarragon, Ernesto
   Jose Moreno, Juan
TI Role of Endocannabinoids on Sweet Taste Perception, Food Preference, and
   Obesity-related Disorders
SO CHEMICAL SENSES
LA English
DT Review
DE 2-arachidonoylglycerol; anandamide; inflammation; natural reinforcers;
   reward; sweet taste; type 2 diabetes
ID CANNABINOID RECEPTOR GENE; CARDIOVASCULAR RISK-FACTORS; OXIDATIVE
   STRESS; CB1 RECEPTORS; HIGH-FAT; MOLECULAR CHARACTERIZATION; G1359A
   POLYMORPHISM; ANOREXIA-NERVOSA; EATING BEHAVIOR; INDIVIDUAL-DIFFERENCES
AB The prevalence of obesity and obesity-related disorders such as type 2 diabetes (T2D) and metabolic syndrome has increased significantly in the past decades, reaching epidemic levels and therefore becoming a major health issue worldwide. Chronic overeating of highly palatable foods is one of the main responsible aspects behind overweight. Food choice is driven by food preference, which is influenced by environmental and internal factors, from availability to rewarding properties of food. Consequently, the acquisition of a dietary habit that may lead to metabolic alterations is the result of a learning process in which many variables take place. From genetics to socioeconomic status, the response to food and how this food affects energy metabolism is heavily influenced, even before birth. In this work, we review how food preference is acquired and established, particularly as regards sweet taste; towards which flavors and tastes we are positively predisposed by our genetic background, our early experience, further lifestyle, and our surroundings; and, especially, the role that the endocannabinoid system (ECS) plays in all of this. Ultimately, we try to summarize why this system is relevant for health purposes and how this is linked to important aspects of eating behavior, as its function as a modulator of energy homeostasis affects, and is affected by, physiological responses directly associated with obesity.
C1 [Tarragon, Ernesto] Univ Trier, Inst Psychobiol, Dept Neurobehav Genet, D-54290 Trier, Germany.
   [Jose Moreno, Juan] Univ Barcelona, Inst Nutr & Food Safety, Dept Nutr Food Sci & Gastron, Gran Via Corts Catalanes 585, E-08007 Barcelona, Spain.
   [Jose Moreno, Juan] Inst Salud Carlos III, CIBEROBN Fisiopatol Obesidad & Nutr, C Monforte de Lemos 3-5,Pabellon 11 Planta 0, Madrid 28029, Spain.
C3 Universitat Trier; University of Barcelona; CIBER - Centro de
   Investigacion Biomedica en Red; CIBEROBN; Instituto de Salud Carlos III
RP Tarragon, E (corresponding author), Univ Trier, Inst Psychobiol, Dept Neurobehav Genet, Johanniterufer 15, D-54290 Trier, Germany.
EM tarrgon@uni-trier.de
RI E, Tarragon/C-9342-2015; Moreno, Juan/AAA-1312-2019; Tarragon Cros,
   Ernesto/P-5224-2016
OI Tarragon Cros, Ernesto/0000-0001-9575-5585
FU Spanish Ministry of Economy and Innovation [AGL2013-49083-C3-1-R,
   AGL2016-75329R]; Autonomous Government of Catalonia [2009SGR0438,
   2014SGR0773]; Alexander von Humboldt Foundation under Alexander von
   Humboldt Postdoctoral Fellowship program
FX This work was supported in part by Spanish Ministry of Economy and
   Innovation (AGL2013-49083-C3-1-R and AGL2016-75329R) and by the
   Autonomous Government of Catalonia (2009SGR0438 and 2014SGR0773). Dr
   Ernesto Tarragon Cros was funded by the Alexander von Humboldt
   Foundation under the Alexander von Humboldt Postdoctoral Fellowship
   program.
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NR 169
TC 23
Z9 26
U1 0
U2 26
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0379-864X
EI 1464-3553
J9 CHEM SENSES
JI Chem. Senses
PD JAN
PY 2018
VL 43
IS 1
BP 3
EP 16
DI 10.1093/chemse/bjx062
PG 14
WC Behavioral Sciences; Food Science & Technology; Neurosciences;
   Physiology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Behavioral Sciences; Food Science & Technology; Neurosciences &
   Neurology; Physiology
GA FS2VL
UT WOS:000419637300001
PM 29293950
DA 2025-06-11
ER

PT J
AU Atkin, SL
   Katsiki, N
   Derosa, G
   Maffioli, P
   Sahebkar, A
AF Atkin, Stephen L.
   Katsiki, Niki
   Derosa, Giuseppe
   Maffioli, Pamela
   Sahebkar, Amirhossein
TI Curcuminoids Lower Plasma Leptin Concentrations: A Meta-analysis
SO PHYTOTHERAPY RESEARCH
LA English
DT Review
DE curcumin; leptin; turmeric; meta-analysis
ID RANDOMIZED CONTROLLED-TRIAL; FATTY LIVER-DISEASE; CLINICAL-PRACTICE;
   MOLECULAR-MECHANISMS; PIPERINE COMBINATION; METABOLIC SYNDROME;
   OXIDATIVE STRESS; GENE-EXPRESSION; DOUBLE-BLIND; OSTEOARTHRITIS
AB Curcumin is a naturally occurring polyphenol that has been suggested to improve several metabolic diseases. Leptin is an adipokine involved in metabolic status and appetite, with marked crosstalk with other systems. Available data suggest that curcumin may affect leptin levels; therefore, this meta-analysis was performed to evaluate this. A systematic review and meta-analysis were undertaken on all randomized controlled trials of curcumin studies that included the measurement of leptin. The search included PubMed-Medline, Scopus, ISI Web of Knowledge, and Google Scholar databases. Quantitative data synthesis was performed by using a random-effects model, with standardized mean difference and 95% confidence interval as summary statistics. A funnel plot, Begg's rank correlation, and Egger's weighted regression tests assessed the presence of publication bias. Four eligible articles comprising five treatment arms were selected for the meta-analysis. Meta-analysis showed a significant decrease in plasma leptin concentrations following curcumin treatment (standardized mean difference: -0.69, 95% confidence interval: -1.16, -0.23, p=0.003; I-2=76.53%). There was no evidence of publication bias. This meta-analysis showed that curcumin supplementation is associated with a decrease in leptin levels that may be regarded as a potential mechanism for the metabolic effects of curcumin. Copyright (c) 2017 John Wiley & Sons, Ltd.
C1 [Atkin, Stephen L.] Weill Cornell Med Qatar, Doha, Qatar.
   [Katsiki, Niki] Aristotle Univ Thessaloniki, Sch Med, Hippocrat Hosp, Propedeut Dept Internal Med 2, Thessaloniki, Greece.
   [Derosa, Giuseppe; Maffioli, Pamela] Univ Pavia, Dept Internal Med & Therapeut, Pavia, Italy.
   [Derosa, Giuseppe] Fdn IRCCS Policlin S MatteoPavia, Pavia, Italy.
   [Derosa, Giuseppe] Univ Pavia, Ctr Study Endocrine Metab Pathophysiol & Clin Res, Pavia, Italy.
   [Derosa, Giuseppe] Univ Pavia, Mol Med Lab, Pavia, Italy.
   [Maffioli, Pamela] Fdn IRCCS Policlin S Matteo, Pavia, Italy.
   [Maffioli, Pamela] Univ Pavia, PhD Sch Expt Med, Pavia, Italy.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Biotechnol Res Ctr, Mashhad 9177948564, Iran.
C3 Qatar Foundation (QF); Weill Cornell Medical College Qatar; Aristotle
   University of Thessaloniki; University of Pavia; University of Pavia;
   University of Pavia; IRCCS Fondazione San Matteo; University of Pavia;
   Mashhad University of Medical Sciences
RP Sahebkar, A (corresponding author), Mashhad Univ Med Sci, Sch Med, Dept Med Biotechnol, POB 91779-48564, Mashhad, Iran.
EM sahebkara@mums.ac.ir
RI Sahebkar, Amirhossein/B-5124-2018; Derosa, Giuseppe/H-8571-2019;
   Maffioli, Pamela/ABH-3390-2021; Atkin, stephen/ABE-7047-2020; Maffioli,
   Pamela/E-9753-2012; Atkin, Stephen/D-7400-2014; KATSIKI,
   NIKI/ADE-7999-2022
OI Maffioli, Pamela/0000-0002-4285-6507; Atkin,
   Stephen/0000-0002-5887-7257; KATSIKI, NIKI/0000-0003-0894-2644
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NR 50
TC 25
Z9 26
U1 1
U2 21
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0951-418X
EI 1099-1573
J9 PHYTOTHER RES
JI Phytother. Res.
PD DEC
PY 2017
VL 31
IS 12
BP 1836
EP 1841
DI 10.1002/ptr.5905
PG 6
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA FO9WN
UT WOS:000417249000004
PM 28880413
DA 2025-06-11
ER

PT J
AU Dhamrait, SS
   Maubaret, C
   Pedersen-Bjergaard, U
   Brull, DJ
   Gohlke, P
   Payne, JR
   World, M
   Thorsteinsson, B
   Humphries, SE
   Montgomery, HE
AF Dhamrait, Sukhbir S.
   Maubaret, Cecilia
   Pedersen-Bjergaard, Ulrik
   Brull, David J.
   Gohlke, Peter
   Payne, John R.
   World, Michael
   Thorsteinsson, Birger
   Humphries, Steve E.
   Montgomery, Hugh E.
TI Mitochondrial uncoupling proteins regulate angiotensin-converting enzyme
   expression: crosstalk between cellular and endocrine metabolic
   regulators suggested by RNA interference and genetic studies
SO BIOESSAYS
LA English
DT Article
DE ACE; association studies; endothelial cell; gene expression; genetics;
   uncoupling protein
ID OXYGEN SPECIES PRODUCTION; PANCREATIC BETA-CELLS; DIET-INDUCED OBESITY;
   MIDDLE-AGED HUMANS; BODY-MASS INDEX; OXIDATIVE STRESS;
   INSULIN-RESISTANCE; DIABETES-MELLITUS; SKELETAL-MUSCLE; ADIPOSE-TISSUE
AB Uncoupling proteins (UCPs) regulate mitochondrial function, and thus cellular metabolism. Angiotensin-converting enzyme (ACE) is the central component of endocrine and local tissue renin-angiotensin systems (RAS), which also regulate diverse aspects of whole-body metabolism and mitochondrial function (partly through altering mitochondrial UCP expression). We show that ACE expression also appears to be regulated by mitochondrial UCPs. In genetic analysis of two unrelated populations (healthy young UK men and Scandinavian diabetic patients) serum ACE (sACE) activity was significantly higher amongst UCP3-55C (rather than T) and UCP2 I (rather than D) allele carriers. RNA interference against UCP2 in human umbilical vein endothelial cells reduced UCP2 mRNA sixfold (P< 0.01) whilst increasing ACE expression within a physiological range (<1.8-fold at 48 h; P< 0.01). Our findings suggest novel hypotheses. Firstly, cellular feedback regulation may occur between UCPs and ACE. Secondly, cellular UCP regulation of sACE suggests a novel means of crosstalk between (and mutual regulation of) cellular and endocrine metabolism. This might partly explain the reduced risk of developing diabetes and metabolic syndrome with RAS antagonists and offer insight into the origins of cardiovascular disease in which UCPs and ACE both play a role.
C1 [Dhamrait, Sukhbir S.; Brull, David J.; Payne, John R.; Humphries, Steve E.] UCL, BHF Labs, Ctr Cardiovasc Genet, London, England.
   [Dhamrait, Sukhbir S.] Western Sussex Hosp NHS Trust, Dept Cardiol, Chichester, W Sussex, England.
   [Maubaret, Cecilia] Ctr INSERM U897 Epidemiol Biostat, Bordeaux, France.
   [Pedersen-Bjergaard, Ulrik; Thorsteinsson, Birger] Hillerod Hosp, Dept Cardiol Nephrol & Endocrinol, Hillerod, Denmark.
   [Pedersen-Bjergaard, Ulrik; Thorsteinsson, Birger] Univ Copenhagen, Fac Hlth Sci, Copenhagen, Denmark.
   [Brull, David J.] Whittington Hosp NHS Trust, Dept Cardiol, London, England.
   [Gohlke, Peter] Univ Hosp Schleswig Holstein, Inst Expt & Clin Pharmacol, Kiel, Germany.
   [Payne, John R.] Golden Jubilee Natl Hosp, Scottish Natl Adv Heart Failure Serv, Clydebank, Scotland.
   [World, Michael] Queen Elizabeth Hosp, Royal Ctr Def Med, Birmingham, W Midlands, England.
   [Montgomery, Hugh E.] UCL, London, England.
   [Montgomery, Hugh E.] UCL, Natl Ctr Sport Exercise & Hlth, London, England.
   [Montgomery, Hugh E.] UCL, UCL Inst Human Hlth & Performance, London, England.
C3 University of London; University College London; Institut National de la
   Sante et de la Recherche Medicale (Inserm); University of Copenhagen;
   University of Copenhagen; University of Kiel; Schleswig Holstein
   University Hospital; Golden Jubilee Hospital; University of Birmingham;
   Royal Centre for Defence Medicine; University of London; University
   College London; University of London; University College London;
   University of London; University College London
RP Dhamrait, SS (corresponding author), UCL, BHF Labs, Ctr Cardiovasc Genet, London, England.; Dhamrait, SS (corresponding author), Western Sussex Hosp NHS Trust, Dept Cardiol, Chichester, W Sussex, England.
EM Sukhbir.Dhamrait@nhs.net
RI Montgomery, Hugh/L-1229-2019; Pedersen-Bjergaard, Ulrik/AAI-2425-2019;
   Humphries, Stephen/C-5075-2008; Montgomery, Hugh/C-2592-2008
OI Montgomery, Hugh/0000-0001-8797-5019
FU British Heart Foundation; National Institute for Health Research
   University College London Hospitals Biomedical Research Centre
FX This work was supported by The British Heart Foundation, which provides
   core funding to UCL Centre for Cardiovascular Genetics, and we express
   our thanks to them. H. M. was supported by the National Institute for
   Health Research University College London Hospitals Biomedical Research
   Centre.
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NR 95
TC 1
Z9 1
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0265-9247
EI 1521-1878
J9 BIOESSAYS
JI Bioessays
PD JUL
PY 2016
VL 38
SU 1
BP S107
EP S118
DI 10.1002/bies.201670909
PG 12
WC Biochemistry & Molecular Biology; Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics
GA DV3XE
UT WOS:000382857700012
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Tsuzuki, T
   Shinozaki, S
   Nakamoto, H
   Kaneki, M
   Goto, S
   Shimokado, K
   Kobayashi, H
   Naito, H
AF Tsuzuki, Takamasa
   Shinozaki, Shohei
   Nakamoto, Hideko
   Kaneki, Masao
   Goto, Sataro
   Shimokado, Kentaro
   Kobayashi, Hiroyuki
   Naito, Hisashi
TI Voluntary Exercise Can Ameliorate Insulin Resistance by Reducing
   iNOS-Mediated S-Nitrosylation of Akt in the Liver in Obese Rats
SO PLOS ONE
LA English
DT Article
ID NITRIC-OXIDE SYNTHASE; HYPERPHAGIC OLETF RATS; PROTEIN-KINASE-B/AKT;
   SKELETAL-MUSCLE; ADIPOSE-TISSUE; ENDURANCE EXERCISE; METABOLIC SYNDROME;
   RECEPTOR SUBSTRATE-1; GLUCOSE-HOMEOSTASIS; NITROSATIVE STRESS
AB Voluntary exercise can ameliorate insulin resistance. The underlying mechanism, however, remains to be elucidated. We previously demonstrated that inducible nitric oxide synthase (iNOS) in the liver plays an important role in hepatic insulin resistance in the setting of obesity. In this study, we tried to verify our hypothesis that voluntary exercise improves insulin resistance by reducing the expression of iNOS and subsequent S-nitrosylation of key molecules of glucose metabolism in the liver. Twenty-one Otsuka Long-Evans Tokushima Fatty (OLETF) rats, a model of type 2 diabetes mellitus, and 18 non-diabetic control Long-Evans Tokushima Otsuka (LETO) rats were randomly assigned to a sedentary group or exercise group subjected to voluntary wheel running for 20 weeks. The voluntary exercise significantly reduced the fasting blood glucose and HOMA-IR in the OLETF rats. In addition, the exercise decreased the amount of iNOS mRNA in the liver in the OLETF rats. Moreover, exercise reduced the levels of S-nitrosylated Akt in the liver, which were increased in the OLETF rats, to those observed in the LETO rats. These findings support our hypothesis that voluntary exercise improves insulin resistance, at least partly, by suppressing the iNOS expression and subsequent S-nitrosylation of Akt, a key molecule of the signal transduction pathways in glucose metabolism in the liver.
C1 [Tsuzuki, Takamasa; Kobayashi, Hiroyuki; Naito, Hisashi] Juntendo Univ, Grad Sch Hlth & Sports Sci, Chiba, Japan.
   [Tsuzuki, Takamasa] Japan Soc Promot Sci, Tokyo, Japan.
   [Shinozaki, Shohei] Tokyo Med & Dent Univ, Grad Sch Med, Dept Arteriosclerosis & Vasc Biol, Tokyo, Japan.
   [Nakamoto, Hideko; Goto, Sataro] Juntendo Univ, Grad Sch Hlth & Sports Sci, Inst Hlth & Sports Sci & Med, Chiba, Japan.
   [Kaneki, Masao] Harvard Univ, Sch Med, Shriners Hosp Children, Dept Anesthesia Crit Care & Pain Med,Massachusett, Charlestown, MA USA.
   [Shimokado, Kentaro] Tokyo Med & Dent Univ, Grad Sch Med, Dept Geriatr & Vasc Med, Tokyo, Japan.
   [Kobayashi, Hiroyuki] Tsukuba Univ Hosp, Mito Med Ctr, Dept Gen Med, Ibaraki, Japan.
C3 Juntendo University; Japan Society for the Promotion of Science;
   Institute of Science Tokyo; Tokyo Medical & Dental University (TMDU);
   Juntendo University; Harvard University; Institute of Science Tokyo;
   Tokyo Medical & Dental University (TMDU); University of Tsukuba
RP Naito, H (corresponding author), Juntendo Univ, Grad Sch Hlth & Sports Sci, Chiba, Japan.
EM hnaitou@juntendo.ac.jp
RI Shinozaki, Shohei/AAT-3018-2021; Naito, Hisashi/F-5655-2011; Tsuzuki,
   Takamasa/S-3563-2019
OI Tsuzuki, Takamasa/0000-0002-0241-1183; Andrews, Zane
   B./0000-0002-9097-7944
FU MEXT-Supported Program for the Strategic Research Foundation at Private
   Universities [S1101008]; JSPS [13J10819]; JSPS KANKENHI [25860231]; Kato
   Memorial Bioscience Foundation; Takeda Science Foundation; Japan
   Atherosclerosis Research Foundation; Grants-in-Aid for Scientific
   Research [13J10819] Funding Source: KAKEN
FX This work was supported by grants from the MEXT-Supported Program for
   the Strategic Research Foundation at Private Universities (S1101008) to
   H. Naito, a Grant-in-Aid for JSPS Fellows (13J10819) to T. Tsuzuki, JSPS
   KANKENHI (25860231), Kato Memorial Bioscience Foundation and Takeda
   Science Foundation to S. Shinozaki and the Japan Atherosclerosis
   Research Foundation to K. Shimokado. The funders had no role in the
   study design, data collection and analysis, decision to publish or
   preparation of the manuscript.
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NR 64
TC 27
Z9 29
U1 0
U2 4
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JUL 14
PY 2015
VL 10
IS 7
AR e0132029
DI 10.1371/journal.pone.0132029
PG 16
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA CN1QN
UT WOS:000358194900027
PM 26172834
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Jeon, BT
   Jeong, EA
   Shin, HJ
   Lee, Y
   Lee, DH
   Kim, HJ
   Kang, SS
   Cho, GJ
   Choi, WS
   Roh, GS
AF Jeon, Byeong Tak
   Jeong, Eun Ae
   Shin, Hyun Joo
   Lee, Younghyurk
   Lee, Dong Hoon
   Kim, Hyun Joon
   Kang, Sang Soo
   Cho, Gyeong Jae
   Choi, Wan Sung
   Roh, Gu Seob
TI Resveratrol Attenuates Obesity-Associated Peripheral and Central
   Inflammation and Improves Memory Deficit in Mice Fed a High-Fat Diet
SO DIABETES
LA English
DT Article
ID ACTIVATED PROTEIN-KINASE; TYPE-2 DIABETES-MELLITUS; GROWTH-FACTOR
   EXPRESSION; ALZHEIMERS-DISEASE; INSULIN-RESISTANCE; PROINFLAMMATORY
   RESPONSE; METABOLIC SYNDROME; OXIDATIVE STRESS; ADIPOSE-TISSUE;
   ADIPONECTIN
AB Obesity-induced diabetes is associated with chronic inflammation and is considered a risk factor for neurodegeneration. We tested the hypothesis that an AMP-activated protein kinase activator, resveratrol (RES), which is known to exert potent anti-inflammatory effects, would attenuate peripheral and central inflammation and improve memory deficit in mice fed a high-fat diet (HFD). C57BL/6J mice were fed an HFD or an HFD supplemented with RES for 20 weeks. Metabolic parameters in serum were evaluated, and Western blot analysis and immunohistochemistry in peripheral organs and brain were completed. We used the Morris water maze test to study the role of RES on memory function in HFD-treated mice. RES treatment reduced hepatic steatosis, macrophage infiltration, and insulin resistance in HFD-fed mice. In the hippocampus of HFD-fed mice, the protein levels of tumor necrosis factor-alpha and Iba-1 expression were reduced by RES treatment. Choline acetyltransferase was increased, and the phosphorylation of tau was decreased in the hippocampus of HFD-fed mice upon RES treatment. In particular, we found that RES significantly improved memory deficit in HFD-fed mice. These findings indicate that RES reverses obesity-related peripheral and central inflammation and metabolic derangements and improves memory deficit in HFD-fed diabetic mice. Diabetes 61:1444-1454, 2012
C1 [Jeon, Byeong Tak; Jeong, Eun Ae; Shin, Hyun Joo; Lee, Younghyurk; Lee, Dong Hoon; Kim, Hyun Joon; Kang, Sang Soo; Cho, Gyeong Jae; Choi, Wan Sung; Roh, Gu Seob] Gyeongsang Natl Univ Sch Med, Med Res Ctr Neural Dysfunct, Inst Hlth Sci, Dept Anat & Neurobiol, Jinju, Gyeongnam, South Korea.
C3 Gyeongsang National University
RP Roh, GS (corresponding author), Gyeongsang Natl Univ Sch Med, Med Res Ctr Neural Dysfunct, Inst Hlth Sci, Dept Anat & Neurobiol, Jinju, Gyeongnam, South Korea.
EM anaroh@gnu.ac.kr
RI Kim, Jungsun/J-3736-2015; Kim, Yun-Gon/HLP-9951-2023
FU National Research Foundation of Korea; Ministry of Education, Science,
   and Technology [2011-0006196]
FX This research was supported by the Basic Science Research Program
   through the National Research Foundation of Korea funded by the Ministry
   of Education, Science, and Technology (No. 2011-0006196).
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NR 50
TC 281
Z9 307
U1 1
U2 64
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0012-1797
J9 DIABETES
JI Diabetes
PD JUN
PY 2012
VL 61
IS 6
BP 1444
EP 1454
DI 10.2337/db11-1498
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 948FX
UT WOS:000304490100021
PM 22362175
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Yamaji, M
   Tsutamoto, T
   Tanaka, T
   Kawahara, C
   Nishiyama, K
   Yamamoto, T
   Fujii, M
   Horie, M
AF Yamaji, Masayuki
   Tsutamoto, Takayoshi
   Tanaka, Toshinari
   Kawahara, Chiho
   Nishiyama, Keizo
   Yamamoto, Takashi
   Fujii, Masanori
   Horie, Minoru
TI Effect of Carperitide on Plasma Adiponectin Levels in Acute
   Decompensated Heart Failure Patients With Diabetes Mellitus
SO CIRCULATION JOURNAL
LA English
DT Article
DE Acute decompensated heart failure; Adiponectin; Aldosterone;
   Carperitide; Diabetes mellitus
ID ATRIAL-NATRIURETIC-PEPTIDE; ADIPOSE-SPECIFIC PROTEIN;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; MYOCARDIAL-INFARCTION; HUMAN
   ADIPOCYTES; NONDIABETIC PATIENTS; OXIDATIVE STRESS; IN-VIVO; OBESITY
AB Background: It is reported that adiponectin has a cardioprotective effect and is decreased in type 2 diabetes mellitus (DM).
   Methods and Results: The effect of carperitide (atrial natriuretic peptide: ANP) on plasma adiponectin levels was evaluated in acute decompensated heart failure (ADHF) patients with and without DM. In 47 patients (DM: n=11) who were admitted with ADHF, blood samples were collected before and 7 days after administration of carperitide. The plasma levels of ANP, brain natriuretic peptide (BNP), aldosterone and adiponectin were measured. Plasma adiponectin levels were significantly increased (17.6 +/- 1.5 to 19.6 +/- 1.8 mu g/ml, P=0.0003) concomitant with the increase in ANP and decrease in BNP 7 days after carperitide infusion. Although adiponectin levels before treatment were slightly lower in ADHF patients with DM, the % increase in adiponectin levels was significantly greater in ADHF patients with DM than in those without DM (26.7 vs 6.6%, P=0.007). In the stepwise multivariate analyses, a higher plasma aldosterone levels before treatment (P=0.04) and DM (P=0.01) were significant independent predictors of a greater % increase in adiponectin levels after treatment with carperitide.
   Conclusions: Carperitide infusion increases the plasma adiponectin level, especially in ADHF patients with DM. (Circ J 2009; 73: 2264-2269)
C1 [Yamaji, Masayuki; Tsutamoto, Takayoshi; Tanaka, Toshinari; Kawahara, Chiho; Nishiyama, Keizo; Yamamoto, Takashi; Fujii, Masanori; Horie, Minoru] Shiga Univ Med Sci, Otsu, Shiga 5202192, Japan.
C3 Shiga University of Medical Science
RP Tsutamoto, T (corresponding author), Shiga Univ Med Sci, Otsu, Shiga 5202192, Japan.
EM tutamoto@belle.shiga-med.ac.jp
RI Horie, Minoru/ABG-7128-2020
OI Horie, Minoru/0000-0002-9029-2339
FU Grant-in-Aid for Scientific Research in Japan
FX We thank Yoko Watanabe for excellent technical assistance. We also
   express our thanks to Mr Daniel Mrozek for assistance in preparing the
   manuscript. This study was supported by a Grant-in-Aid for Scientific
   Research in Japan.
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NR 44
TC 10
Z9 10
U1 0
U2 0
PU JAPANESE CIRCULATION SOC
PI TOYKO
PA 18TH FLOOR IMPERIAL HOTEL TOWER, 1-1-1 UCHISAIWAI-CHO CHIYODA-KU, TOYKO,
   100-0011, JAPAN
SN 1346-9843
EI 1347-4820
J9 CIRC J
JI Circ. J.
PD DEC
PY 2009
VL 73
IS 12
BP 2264
EP 2269
DI 10.1253/circj.CJ-09-0371
PG 6
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 525HW
UT WOS:000272206900017
PM 19797823
OA Bronze
DA 2025-06-11
ER

PT J
AU Silva, JG
   Tavares, L
   Belew, GD
   Rodrigues, JA
   Araújo, R
   Gil, AM
   Jones, JG
AF Silva, Joao G.
   Tavares, Ludgero
   Belew, Getachew D.
   Rodrigues, Joao A.
   Araujo, Rita
   Gil, Ana M.
   Jones, John G.
TI Impact of High-Fat Diet-induced Metabolic Dysfunction-associated
   Steatotic Liver Disease on Heart, Kidney, and Skeletal Muscle
   Metabolomes in Wild-Type Mice
SO JOURNAL OF PROTEOME RESEARCH
LA English
DT Article
DE metabolic dysfunction-associated steatotic liver disease; metabolomics;
   extrahepatic tissues; metabolic syndrome; nuclear magnetic resonance;
   tissue extracts
ID MAGNETIC-RESONANCE-SPECTROSCOPY; DE-NOVO LIPOGENESIS;
   INSULIN-RESISTANCE; TRIGLYCERIDE CONTENT; HUMANS; NAFLD;
   CARDIOPROTECTION; CARBOHYDRATE; PATHOGENESIS; MODULATION
AB Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) can be recapitulated in mice fed a high-fat diet. The development of MASLD and the diet per se can both perturb metabolism in key extrahepatic tissues such as the heart, kidney, and skeletal muscle. To date, these alterations have not been well described in this animal model of diet-induced MASLD. Methodology: Male C57BL/6J mice were fed either standard (SC, n = 12) or high-fat chow (HF, n = 11) for 18 weeks. Metabolites were extracted from the heart, kidney, and skeletal muscle and analyzed by 1H nuclear magnetic resonance (NMR) spectroscopy, along with multivariate and univariate statistical analyses. Results: Kidney metabolite profiles exhibited the largest differences between HF and SC diets, followed by those of skeletal muscle and then the heart. Some alterations were common across all tissues, namely decreased trimethylamine and elevated levels of linoleic acid and polyunsaturated fatty acids in HF compared to SC (p < 0.05 for all three metabolites). Overall, the metabolite variations were consistent with shifts in carbohydrate and lipid substrate selection for oxidation, increased tissue stress in the heart and kidneys, and altered choline metabolism. These findings may serve as additional important descriptors of MASLD onset and progression.
C1 [Silva, Joao G.; Tavares, Ludgero; Belew, Getachew D.; Jones, John G.] Univ Coimbra, Inst Interdisciplinary Res III UC, Ctr Innovat Biomed & Biotechnol CIBB, Metab Aging & Dis, P-3060197 Cantanhede, Portugal.
   [Silva, Joao G.] Univ Coimbra, Inst Interdisciplinary Res III UC, Doctoral Programme Expt Biol & Biomed PDBEB, P-3030789 Coimbra, Portugal.
   [Silva, Joao G.; Tavares, Ludgero] Univ Sch Vasco da Gama EUVG, Vasco da Gama Res Ctr CIVG, P-3020210 Coimbra, Portugal.
   [Belew, Getachew D.] Ohio Univ, Heritage Coll Osteopath Med, Dept Biomed Sci, Athens, OH 45701 USA.
   [Silva, Joao G.; Rodrigues, Joao A.; Araujo, Rita; Gil, Ana M.] Univ Aveiro, Dept Chem, P-3810193 Aveiro, Portugal.
   [Silva, Joao G.; Rodrigues, Joao A.; Araujo, Rita; Gil, Ana M.] Univ Aveiro, CICECO Aveiro Inst Mat, P-3810193 Aveiro, Portugal.
C3 Universidade de Coimbra; Universidade de Coimbra; University System of
   Ohio; Ohio University; Universidade de Aveiro; Universidade de Aveiro
RP Silva, JG; Jones, JG (corresponding author), Univ Coimbra, Inst Interdisciplinary Res III UC, Ctr Innovat Biomed & Biotechnol CIBB, Metab Aging & Dis, P-3060197 Cantanhede, Portugal.; Silva, JG (corresponding author), Univ Coimbra, Inst Interdisciplinary Res III UC, Doctoral Programme Expt Biol & Biomed PDBEB, P-3030789 Coimbra, Portugal.; Silva, JG (corresponding author), Univ Sch Vasco da Gama EUVG, Vasco da Gama Res Ctr CIVG, P-3020210 Coimbra, Portugal.; Silva, JG (corresponding author), Univ Aveiro, Dept Chem, P-3810193 Aveiro, Portugal.; Silva, JG (corresponding author), Univ Aveiro, CICECO Aveiro Inst Mat, P-3810193 Aveiro, Portugal.
EM jgsilva@cnc.uc.pt; cnc_jones@cnc.uc.pt
RI Silva, João/ABG-1901-2021; Tavares, Ludgero/A-1325-2012; Rodrigues,
   Joao/AAD-8183-2020; Gil, Ana/B-5440-2013
OI Gil, Ana/0000-0003-3766-4364; Silva, Joao Gabriel/0000-0002-1150-1893;
   Rodrigues, Joao A./0000-0002-8621-5410; Jones, John/0000-0002-3745-3885
FU European Regional Development Fund (ERDF) through the Centro 2020
   Regional Operational Program; COMPETE 2020-Operational Program for
   Competitiveness and Internationalisation; Portuguese national funds via
   FCT-Fundacao para a Ciencia e a Tecnologia; Projects CIBB-Centre for
   Innovative Biomedicine and Biotechnology, University of Coimbra
   [PTDC/BIA-BQM/28147/2017, PTDC/BAA-AGR/3550/2020, UIDB/04539/2020,
   UIDP/04539/2020, LA/P/0058/2020]; CICECO-Aveiro Institute of Materials,
   University of Aveiro [UIDB/50011/2020, UIDP/50011/2020, LA/P/0006/2020];
   Infrastructure Project [022161]; FEDER through COMPETE 2020; POCI; PORL;
   FCT through PIDDAC; CIBB; FCT [UIDB/154022/2022]; 
   [FCT-FEDER-02/SAICT/2017/028147]
FX The authors thank Tatiana Carneiro, Daniela Bispo, and Daniela Duarte
   (University of Aveiro, Aveiro, Portugal), as well as Mariana Palma and
   Ivan Viegas (University of Coimbra, Coimbra, Portugal) for their help
   and guidance. This work was financed by the European Regional
   Development Fund (ERDF) through the Centro 2020 Regional Operational
   Program under project FCT-FEDER-02/SAICT/2017/028147 and through the
   COMPETE 2020-Operational Program for Competitiveness and
   Internationalisation and Portuguese national funds via FCT-Fundacao para
   a Ciencia e a Tecnologia, within the scope of the projects CIBB-Centre
   for Innovative Biomedicine and Biotechnology, University of Coimbra,
   grants PTDC/BIA-BQM/28147/2017, PTDC/BAA-AGR/3550/2020, UIDB/04539/2020,
   UIDP/04539/2020, and LA/P/0058/2020, and CICECO-Aveiro Institute of
   Materials, University of Aveiro, grants UIDB/50011/2020 (doi:
   10.54499/UIDB/50011/2020), UIDP/50011/2020 (doi:
   10.54499/UIDP/50011/2020), and LA/P/0006/2020 (doi:
   10.54499/LA/P/0006/2020). The NMR spectrometer is part of the National
   NMR Network (PTNMR) and is partially supported by Infrastructure Project
   No 022161 (cofinanced by FEDER through COMPETE 2020, POCI, and PORL, and
   FCT through PIDDAC). J.G.S. is supported by a PhD grant through CIBB and
   financed by FCT (UIDB/154022/2022).
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NR 77
TC 0
Z9 0
U1 1
U2 1
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1535-3893
EI 1535-3907
J9 J PROTEOME RES
JI J. Proteome Res.
PD APR 13
PY 2025
VL 24
IS 5
BP 2491
EP 2504
DI 10.1021/acs.jproteome.5c00040
EA APR 2025
PG 14
WC Biochemical Research Methods
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 2EU4W
UT WOS:001466861000001
PM 40222045
DA 2025-06-11
ER

PT J
AU Barzalobre-Geronimo, R
   Contreras-Ramos, A
   Cervantes-Cruz, AI
   Cruz, M
   Suárez-Sánchez, F
   Goméz-Zamudio, J
   Diaz-Rosas, G
   Avalos-Rodríguez, A
   Díaz-Flores, M
   Ortega-Camarillo, C
AF Barzalobre-Geronimo, Raul
   Contreras-Ramos, Alejandra
   Cervantes-Cruz, Aaron I.
   Cruz, Miguel
   Suarez-Sanchez, Fernando
   Gomez-Zamudio, Jaime
   Diaz-Rosas, Guadalupe
   Avalos-Rodriguez, Alejandro
   Diaz-Flores, Margarita
   Ortega-Camarillo, Clara
TI Pancreatic β-Cell Apoptosis in Normoglycemic Rats is Due to
   Mitochondrial Translocation of p53-Induced by the Consumption of
   Sugar-Sweetened Beverages
SO CELL BIOCHEMISTRY AND BIOPHYSICS
LA English
DT Article; Early Access
DE beta-cell death; Insulin; miRNAs; Visceral fat; Fructose; Saccharose
ID HIGH-FAT DIET; INSULIN-RESISTANCE; METABOLIC SYNDROME; FRUCTOSE DIET;
   GLUCOSE; P53; OBESITY; STRESS; HYPERTENSION; HOMEOSTASIS
AB Overstimulation of pancreatic beta-cells can lead to dysfunction and death, prior to the clinical manifestations of type 2 diabetes (T2D). The excessive consumption of carbohydrates induces metabolic alterations that can affect the functions of the beta-cells and cause their death. We analyzed the role of p53 in pancreatic beta cell death in carbohydrate-supplemented Sprague Dawley rats. For four months, the animals received drinking water containing either 40% sucrose or 40% fructose. The glucose tolerance test was performed at week 15. Apoptosis was assessed with the TUNEL assay (TdT-mediated dUTP-nick endlabeling). Bax, p53, and insulin were assessed by Western blotting, immunofluorescence, and real-time quantitative PCR. Insulin, triacylglycerol, and serum glucose and fatty acids in pancreatic tissue were measured. Carbohydrate consumption promotes apoptosis and mobilization of p53 from the cytosol to rat pancreatic beta-cell mitochondria before blood glucose rises. An increase in p53, miR-34a, and Bax mRNA was also detected (P < 0.001) in the sucrose group. As well as hypertriglyceridemia, hyperinsulinemia, glucose intolerance, insulin resistance, visceral fat accumulation, and increased pancreatic fatty acids in the sucrose group. Carbohydrate consumption increases p53 and its mobilization into beta-cell mitochondria and coincides with the increased rate of apoptosis, which occurs before serum glucose levels rise.
C1 [Barzalobre-Geronimo, Raul] Univ Nacl Autonoma Mexico, Posgrad Ciencias Biol, Mexico City, Mexico.
   [Barzalobre-Geronimo, Raul; Cervantes-Cruz, Aaron I.; Cruz, Miguel; Suarez-Sanchez, Fernando; Gomez-Zamudio, Jaime; Diaz-Flores, Margarita; Ortega-Camarillo, Clara] Inst Mexicano Seguro Social, Specialties Hosp, Natl Med Ctr SXXI, Med Res Unit Biochem, Mexico City, Mexico.
   [Contreras-Ramos, Alejandra; Diaz-Rosas, Guadalupe] Children Hosp Mexico Federico Gomez HIMFG, Mol Biol Res Lab, Congenital Malformat Ctr, Mexico City, Mexico.
   [Avalos-Rodriguez, Alejandro] Univ Autonoma Metropolitana Xoch, Dept Agr & Anim Prod, Mexico City, Mexico.
C3 Universidad Nacional Autonoma de Mexico; Instituto Mexicano del Seguro
   Social; Universidad Autonoma Metropolitana - Mexico; University Autonoma
   Metropolitana Xochimilco
RP Ortega-Camarillo, C (corresponding author), Inst Mexicano Seguro Social, Specialties Hosp, Natl Med Ctr SXXI, Med Res Unit Biochem, Mexico City, Mexico.
EM cocamarillo2014@gmail.com
RI Contreras, Alejandra/AAG-5814-2020; Ortega, Clara/MSZ-8179-2025; Cruz
   Lopez, Miguel/O-5493-2018
OI Contreras-Ramos, Alejandra/0000-0002-5173-9927; Cruz Lopez,
   Miguel/0000-0001-9985-6172
FU Fondo de Investigacion en Salud, IMSS [FIS/IMSS/PROT/G15/1427]
FX This research was supported by the Fondo de Investigacion en Salud, IMSS
   (Grant. FIS/IMSS/PROT/G15/1427).
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NR 57
TC 2
Z9 2
U1 0
U2 2
PU HUMANA PRESS INC
PI TOTOWA
PA 999 RIVERVIEW DRIVE SUITE 208, TOTOWA, NJ 07512 USA
SN 1085-9195
EI 1559-0283
J9 CELL BIOCHEM BIOPHYS
JI Cell Biochem. Biophys.
PD 2023 JUL 1
PY 2023
AR s12013-023-01147-y
DI 10.1007/s12013-023-01147-y
EA JUL 2023
PG 12
WC Biochemistry & Molecular Biology; Biophysics; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Cell Biology
GA L2ZZ4
UT WOS:001022004900002
PM 37392315
DA 2025-06-11
ER

PT J
AU Noh, JW
   Lee, HY
   Lee, BC
AF Noh, Ji-Won
   Lee, Han-Young
   Lee, Byung-Cheol
TI Mangiferin Ameliorates Obesity-Associated Inflammation and Autophagy in
   High-Fat-Diet-Fed Mice: In Silico and In Vivo Approaches
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE Anemarrhenae rhizoma; mangiferin; inflammation; autophagy; insulin
   resistance; obesity
ID NF-KAPPA-B; INSULIN-RESISTANCE; LIVER-DISEASE; INDIVIDUALS; MECHANISMS;
   INSIGHTS; COLITIS; STRESS
AB Obesity-induced insulin resistance is the fundamental cause of metabolic syndrome. Accordingly, we evaluated the effect of mangiferin (MGF) on obesity and glucose metabolism focusing on inflammatory response and autophagy. First, an in silico study was conducted to analyze the mechanism of MGF in insulin resistance. Second, an in vivo experiment was conducted by administering MGF to C57BL/6 mice with high-fat-diet (HFD)-induced metabolic disorders. The in silico analysis revealed that MGF showed a high binding affinity with macrophage-related inflammatory cytokines and autophagy proteins. In the in vivo study, mice were divided into three groups: normal chow, HFD, and HFD + MGF 150 mg/kg. MGF administration to obese mice significantly improved the body weight, insulin-sensitive organs weights, glucose and lipid metabolism, fat accumulation in the liver, and adipocyte size compared to HFD alone. MGF significantly reduced the macrophages in adipose tissue and Kupffer cells, inhibited the gene expression ratio of tumor necrosis factor-alpha and F4/80 in adipose tissue, reduced the necrosis factor kappa B gene, and elevated autophagy-related gene 7 and fibroblast growth factor 21 gene expressions in the liver. Thus, MGF exerted a therapeutic effect on metabolic diseases by improving glucose and lipid metabolism through inhibition of the macrophage-mediated inflammatory responses and activation of autophagy.
C1 [Noh, Ji-Won; Lee, Han-Young; Lee, Byung-Cheol] Kyung Hee Univ, Grad Sch, Dept Clin Korean Med, 26 Kyungheedae To, Seoul 02447, South Korea.
C3 Kyung Hee University
RP Lee, BC (corresponding author), Kyung Hee Univ, Grad Sch, Dept Clin Korean Med, 26 Kyungheedae To, Seoul 02447, South Korea.
EM hydrolee@khu.ac.kr
RI Lee, Byung-Cheol/AAG-1115-2021
OI Noh, Ji-won/0000-0001-7053-8082; Lee, Byung-Cheol/0000-0003-2209-6229
FU Korea Health Technology R&D Project through the Korea Health Industry
   Development Institute (KHIDI) - Ministry of Health and Welfare, Republic
   of Korea;  [HF20C0022]
FX This research was supported by a grant from the Korea Health Technology
   R&D Project through the Korea Health Industry Development Institute
   (KHIDI), funded by the Ministry of Health and Welfare, Republic of Korea
   (grant number: HF20C0022).
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NR 35
TC 10
Z9 10
U1 2
U2 9
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD DEC
PY 2022
VL 23
IS 23
AR 15329
DI 10.3390/ijms232315329
PG 17
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 6X4VP
UT WOS:000896413000001
PM 36499655
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Seong, M
   Kim, Y
   Park, S
   Kim, H
   Kwon, O
AF Seong, Mingyeong
   Kim, Youjin
   Park, Saejong
   Kim, Hyesook
   Kwon, Oran
TI Association Between Diet Quality and Cardiorespiratory Fitness in Korean
   Adults: The 2014-2015 National Fitness Award Project
SO NUTRIENTS
LA English
DT Article
DE recommended food score; diet; cardiorespiratory fitness; maximal oxygen
   uptake
ID OXIDATIVE STRESS; METABOLIC SYNDROME; PHYSICAL-ACTIVITY;
   CARDIOVASCULAR-DISEASE; OXYGEN INTAKE; VITAMIN-E; ALL-CAUSE; MORTALITY;
   MEN; EXERCISE
AB Cardiorespiratory fitness (CRF) is a strong and meaningful indicator for predicting mortality, including cardiovascular disease, as well as simple physical capacity. Healthy eating is thought to be one of the crucial factors associated with an individual's CRF status, although little research has been done on the relationship between healthy eating and CRF. This study aimed to investigate the association between overall diet quality and CRF among Korean adults. The study involved 937 adults (380 men and 557 women) aged 19-64 years who participated in the 2014-2015 Korea Institute of Sports Science Fitness Standards project. Diet quality was assessed by the recommended food score (RFS), and CRF was determined by maximal oxygen uptake (VO2max) during a treadmill exercise test. Multiple regression model analyses were stratified by age (19-34, 35-49, and 50-64 years) and sex, because both factors greatly influence CRF. After multivariate adjustment, only the 19-34 age group in both sexes showed a positive association between RFS and VO2max. Additionally, when physical activity was adjusted, it was still significant in men but only marginally related in women. Our results suggest that better overall diet quality may be associated with a better CRF among young adults aged 19-34 years in Korea.
C1 [Seong, Mingyeong; Kwon, Oran] Ewha Womans Univ, Grad Sch Clin Hlth Sci, Dept Clin Nutr Sci, 52 Ewhayeodae Gil, Seoul 03760, South Korea.
   [Kim, Youjin; Kim, Hyesook; Kwon, Oran] Ewha Womans Univ, Dept Nutr Sci & Food Management, 52 Ewhayeodae Gil, Seoul 03760, South Korea.
   [Kim, Youjin] Tufts Univ, Friedman Sch Nutr Sci & Policy, Nutr Epidemiol & Data Sci, Boston, MA 02111 USA.
   [Park, Saejong] Korea Inst Sport Sci, Dept Sport Sci, 727 Hwarang Ro, Seoul 01794, South Korea.
C3 Ewha Womans University; Ewha Womans University; Tufts University
RP Kwon, O (corresponding author), Ewha Womans Univ, Grad Sch Clin Hlth Sci, Dept Clin Nutr Sci, 52 Ewhayeodae Gil, Seoul 03760, South Korea.; Kim, H; Kwon, O (corresponding author), Ewha Womans Univ, Dept Nutr Sci & Food Management, 52 Ewhayeodae Gil, Seoul 03760, South Korea.
EM 162cac05@ewhain.net; eugene841226@gmail.com; saejpark@kspo.or.kr;
   khs7882@hanmail.net; orank@ewha.ac.kr
OI Kwon, Oran/0000-0002-2031-7238; Park, Saejong/0000-0001-7229-5790; Kim,
   Hyesook/0000-0002-4840-3082
FU Bio & Medical Technology Development Program of the National Research
   Foundation (NRF) - Ministry of Science ICT [2012M3A9C4048761];
   EwhaWomans University
FX This research was supported by the Bio & Medical Technology Development
   Program of the National Research Foundation (NRF), funded by the
   Ministry of Science & ICT, grant number 2012M3A9C4048761; and by
   RP-Grant 2019 of EwhaWomans University.
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   WONG SHY, 1987, CLIN CHEM, V33, P214
   Yu R, 2011, MATURITAS, V69, P348, DOI 10.1016/j.maturitas.2011.05.003
NR 53
TC 5
Z9 5
U1 0
U2 6
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD NOV
PY 2020
VL 12
IS 11
AR 3226
DI 10.3390/nu12113226
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA OX7ZJ
UT WOS:000593777800001
PM 33105591
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Nagy, RA
   van Montfoort, APA
   Groen, H
   Homminga, I
   Andrei, D
   Mistry, RH
   Anderson, JLC
   Hoek, A
   Tietge, UJF
AF Nagy, Ruxandra A.
   van Montfoort, Aafke P. A.
   Groen, Henk
   Homminga, Irene
   Andrei, Daniela
   Mistry, Rima H.
   Anderson, Josephine L. C.
   Hoek, Annemieke
   Tietge, Uwe J. F.
TI Anti-oxidative function of follicular fluid HDL and outcomes of modified
   natural cycle-IVF
SO SCIENTIFIC REPORTS
LA English
DT Article
ID HIGH-DENSITY-LIPOPROTEIN; ELEVATED OXIDATIVE STRESS; METABOLIC SYNDROME;
   WOMEN; MARKERS; PLASMA; ENDOMETRIOSIS; DYSLIPIDEMIA; INFERTILITY;
   PARAMETERS
AB High density lipoproteins (HDL) are the main cholesterol carriers in follicular fluid (FF), the natural environment of oocyte development. Additionally, HDL have critical biological functions such as anti-oxidative capacity, which have not been studied in reproduction. Therefore, this study aimed to investigate whether the anti-oxidative function of FF-HDL is associated with fertility outcomes. From 253 women undergoing modified natural cycle (MNC)-IVF at a single academic centre FF and plasma were collected (n = 375 cycles). Anti-oxidative function of FF was mainly attributable to HDL (n = 8; 83%). FF-HDL had a higher anti-oxidative function than plasma HDL (n = 19, P < 0.001) coinciding with increased vitamin E and sphingosine 1 phosphate content (P = 0.028 each). Proteomic analysis indicated no significant differences in major anti-oxidative proteins such as paraoxonase 1, apolipoprotein (apo) A-I or apoA-IV between FF-HDL and matched plasma-HDL (n = 5), while apoC-III, apoE and apoC-II were relatively lower in FF-HDL. Finally, FF-HDL anti-oxidative function was related to a decrease in the odds of the oocyte undergoing normal fertilization, an association that persisted after adjustment for confounders (odds ratio 0.97 (0.93-1), P = 0.041). In conclusion, FF-HDL has considerable anti-oxidative properties that might be relevant for embryo quality.
C1 [Nagy, Ruxandra A.; Andrei, Daniela; Mistry, Rima H.; Anderson, Josephine L. C.; Tietge, Uwe J. F.] Univ Groningen, Univ Med Ctr Groningen, Ctr Liver Digest & Metab Dis, Dept Paediat, NL-9713 GZ Groningen, Netherlands.
   [Nagy, Ruxandra A.; van Montfoort, Aafke P. A.; Homminga, Irene; Andrei, Daniela; Hoek, Annemieke] Univ Groningen, Univ Med Ctr Groningen, Dept Obstet & Gynaecol, Sect Reprod Med, NL-9713 GZ Groningen, Netherlands.
   [van Montfoort, Aafke P. A.] Maastricht Univ, Grow Sch Oncol & Dev Biol, Dept Obstet & Gynaecol, Med Ctr, NL-6229 HX Maastricht, Netherlands.
   [Groen, Henk] Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, NL-9713 GZ Groningen, Netherlands.
   [Tietge, Uwe J. F.] Karolinska Inst, Dept Lab Med, Div Clin Chem, Stockholm, Sweden.
   [Tietge, Uwe J. F.] Karolinska Univ Hosp, Karolinska Univ Lab, Clin Chem, SE-14186 Stockholm, Sweden.
C3 University of Groningen; University of Groningen; Maastricht University;
   University of Groningen; Karolinska Institutet; Karolinska Institutet;
   Karolinska University Hospital
RP Tietge, UJF (corresponding author), Univ Groningen, Univ Med Ctr Groningen, Ctr Liver Digest & Metab Dis, Dept Paediat, NL-9713 GZ Groningen, Netherlands.; Tietge, UJF (corresponding author), Karolinska Inst, Dept Lab Med, Div Clin Chem, Stockholm, Sweden.; Tietge, UJF (corresponding author), Karolinska Univ Hosp, Karolinska Univ Lab, Clin Chem, SE-14186 Stockholm, Sweden.
EM uwe.tietge@ki.se
RI Anderson, Josephine/AAW-9680-2020; Groen, Henk/B-2163-2013
OI Homminga, Irene/0000-0002-6794-2102; Groen, Henk/0000-0002-6629-318X;
   Anderson, Josephine/0000-0002-2802-6769; van Montfoort,
   Aafke/0000-0002-7318-3990; Andrei, Daniela/0000-0003-4211-2783
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NR 45
TC 11
Z9 12
U1 0
U2 2
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD SEP 6
PY 2019
VL 9
AR 12817
DI 10.1038/s41598-019-49091-3
PG 9
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA IW0MT
UT WOS:000484656700005
PM 31492916
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Kang, I
   Park, M
   Yang, SJ
   Lee, M
AF Kang, Inhae
   Park, Miyoung
   Yang, Soo Jin
   Lee, Myoungsook
TI Lipoprotein Lipase Inhibitor, Nordihydroguaiaretic Acid, Aggravates
   Metabolic Phenotypes and Alters HDL Particle Size in the Western
   Diet-Fed db/db Mice
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE lipoprotein lipase; nordihydroguaiaretic acid; dyslipidemia; HDL
   particle size
ID APOLIPOPROTEIN-A-I; MYOCARDIAL-INFARCTION; LDL CHOLESTEROL;
   BLOOD-PRESSURE; DOUBLE-BLIND; PLASMA; RISK; DYSLIPIDEMIA; DALCETRAPIB;
   COMBINATION
AB Lipoprotein lipase (LPL) hydrolyzes triglycerides in lipoprotein to supply fatty acids, and its deficiency leads to hypertriglyceridemia, thereby inducing metabolic syndrome (MetSyn). Nordihydroguaiaretic acid (NDGA) has been recently reported to inhibit LPL secretion by endoplasmic reticulum (ER)-Golgi redistribution. However, the role of NDGA on dyslipidemia and MetSyn remains unclear. To address this question, leptin receptor knock out (KO)-db/db mice were randomly assigned to three different groups: A normal AIN76-A diet (CON), a Western diet (WD) and a Western diet with 0.1% NDGA and an LPL inhibitor, (WD+NDGA). All mice were fed for 12 weeks. The LPL inhibition by NDGA was confirmed by measuring the systemic LPL mass and adipose LPL gene expression. We investigated whether the LPL inhibition by NDGA alters the metabolic phenotypes. NDGA led to hyperglycemia, hypertriglyceridemia, and hypercholesterolemia. More strikingly, the supplementation of NDGA increased the percentage of high density lipoprotein (HDL)(small) (HDL3a+3b+3c) and decreased the percentage of HDLlarge (HDL2a+2b) compared to the WD group, which indicates that LPL inhibition modulates HDL subclasses. was NDGA increased adipose inflammation but had no impact on hepatic stress signals. Taken together, these findings demonstrated that LPL inhibition by NDGA aggravates metabolic parameters and alters HDL particle size.
C1 [Kang, Inhae] Jeju Natl Univ, Dept Food Sci & Nutr, Jeju 63243, South Korea.
   [Park, Miyoung; Lee, Myoungsook] Sungshin Womens Univ, Res Inst Obes Sci, Seoul 01133, South Korea.
   [Yang, Soo Jin] Seoul Womens Univ, Dept Food & Nutr, Seoul 01797, South Korea.
   [Lee, Myoungsook] Sungshin Womens Univ, Dept Food & Nutr, Seoul 01133, South Korea.
C3 Jeju National University; Sungshin Women's University; Seoul Women's
   University; Sungshin Women's University
RP Lee, M (corresponding author), Sungshin Womens Univ, Res Inst Obes Sci, Seoul 01133, South Korea.; Lee, M (corresponding author), Sungshin Womens Univ, Dept Food & Nutr, Seoul 01133, South Korea.
EM inhaek@jejunu.ac.kr; mypinehill@naver.com; sjyang89@swu.ac.kr;
   mlee@sungshin.ac.kr
OI Yang, Soo Jin/0000-0001-7892-7648; Lee, Myoungsook/0000-0003-1344-6979
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NR 46
TC 9
Z9 10
U1 0
U2 4
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD JUN 2
PY 2019
VL 20
IS 12
AR 3057
DI 10.3390/ijms20123057
PG 14
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA IG4ED
UT WOS:000473756000207
PM 31234537
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Kundi, H
   Korkmaz, A
   Balun, A
   Cicekcioglu, H
   Kiziltunc, E
   Gursel, K
   Cetin, M
   Ornek, E
   Ileri, M
AF Kundi, Harun
   Korkmaz, Ahmet
   Balun, Ahmet
   Cicekcioglu, Hulya
   Kiziltunc, Emrullah
   Gursel, Koray
   Cetin, Mustafa
   Ornek, Ender
   Ileri, Mehmet
TI Is In-Stent Restenosis After a Successful Coronary Stent Implantation
   Due to Stable Angina Associated With TG/HDL-C Ratio?
SO ANGIOLOGY
LA English
DT Article
DE angina; lipoprotein ratios; stent restenosis; triglyceride to
   high-density lipoprotein cholesterol ratio
ID DENSITY-LIPOPROTEIN-CHOLESTEROL; HEART-DISEASE; INSULIN-RESISTANCE;
   CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; DIABETES-MELLITUS;
   CLINICAL-OUTCOMES; OXIDATIVE STRESS; RISK; TRIGLYCERIDES
AB We examined the impact of the preprocedural triglyceride (TG)/high-density lipoprotein cholesterol (HDL-C) ratio on risk of in-stent restenosis (ISR). Patients with typical anginal symptoms and/or positive treadmill or myocardial perfusion scintigraphy test results who underwent successful coronary stent implantation due to stable angina were examined; 1341 patients were enrolled. The hospital files of the patients were used to gather data. Cox regression analysis showed that the TG/HDL-C ratio was independently associated with the presence of ISR (P < .001). Moreover, diabetes mellitus (P = .007), smaller stent diameter (P = .046), and smoking status (P = .001) were also independently associated with the presence of ISR. Using a cutoff of 3.8, the TG/HDL-C ratio predicted the presence of ISR with a sensitivity of 71% and a specificity of 68%. Also, the highest quartile of TG/HDL-C ratio had the highest rate of ISR (P < .001). Measuring preprocedural TG/HDL-C ratio, in fasting or nonfasting samples, could be beneficial for the risk assessment of ISR. However, further large-scale prospective studies are required to establish the exact role of this simple, easily calculated, and reproducible parameter in the pathogenesis of ISR.
C1 [Kundi, Harun; Korkmaz, Ahmet; Balun, Ahmet; Cicekcioglu, Hulya; Kiziltunc, Emrullah; Gursel, Koray; Cetin, Mustafa; Ornek, Ender; Ileri, Mehmet] Ankara Numune Training & Res Hosp, Dept Cardiol, Bagci Cad 98, TR-06200 Ankara, Turkey.
C3 Ankara Numune Training & Research Hospital
RP Kundi, H (corresponding author), Ankara Numune Training & Res Hosp, Dept Cardiol, Bagci Cad 98, TR-06200 Ankara, Turkey.
EM harunkundi@hotmail.com
RI Çetin, Mustafa/GPK-2638-2022; Örnek, Ender/AAI-2423-2019; balun,
   ahmet/AAY-3987-2021; Çiçekçioğlu, Hülya/ITW-2109-2023; Ileri,
   Mehmet/A-6525-2018; Kızıltunç, Emrullah/AAQ-3582-2020; Kundi,
   Harun/F-5340-2015
OI BALUN, AHMET/0000-0002-7723-9912; Kundi, Harun/0000-0002-0303-9619; ,
   Mustafa Cetin/0000-0001-7542-6602
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NR 53
TC 11
Z9 13
U1 0
U2 2
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0003-3197
EI 1940-1574
J9 ANGIOLOGY
JI Angiology
PD OCT
PY 2017
VL 68
IS 9
BP 816
EP 822
DI 10.1177/0003319716689366
PG 7
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA FF7RK
UT WOS:000409213500012
PM 28068799
DA 2025-06-11
ER

PT J
AU Novakovic, M
   Jug, B
   Lenasi, H
AF Novakovic, Marko
   Jug, Borut
   Lenasi, Helena
TI Clinical impact of exercise in patients with peripheral arterial disease
SO VASCULAR
LA English
DT Review
DE Peripheral arterial disease; intermittent claudication; exercise;
   walking; rehabilitation; cardiovascular risk
ID ANKLE-BRACHIAL INDEX; RANDOMIZED CONTROLLED-TRIAL;
   CORONARY-HEART-DISEASE; QUALITY-OF-LIFE; SUPERVISED EXERCISE;
   INTERMITTENT CLAUDICATION; METABOLIC SYNDROME; PHYSICAL-ACTIVITY;
   LOWER-EXTREMITY; RISK-FACTORS
AB Increasing prevalence, high morbidity and mortality, and decreased health-related quality of life are hallmarks of peripheral arterial disease. About one-third of peripheral arterial disease patients have intermittent claudication with deleterious effects on everyday activities, such as walking. Exercise training improves peripheral arterial disease symptoms and is recommended as first line therapy for peripheral arterial disease. This review examines the effects of exercise training beyond improvements in walking distance, namely on vascular function, parameters of inflammation, activated hemostasis and oxidative stress, and quality of life. Exercise training not only increases walking distance and physiologic parameters in patients with peripheral arterial disease, but also improves the cardiovascular risk profile by helping patients achieve better control of hypertension, hyperglycemia, obesity and dyslipidemia, thus further reducing cardiovascular risk and the prevalence of coexistent atherosclerotic diseases. American guidelines suggest supervised exercise training, performed for a minimum of 30-45 min, at least three times per week, for at least 12 weeks. Walking is the most studied exercise modality and its efficacy in improving cardiovascular parameters in patients with peripheral arterial disease has been extensively proven. As studies have shown that supervised exercise training improves walking performance, cardiovascular parameters and quality of life in patients with peripheral arterial disease, it should be encouraged and more often prescribed.
C1 [Novakovic, Marko; Jug, Borut] Univ Med Ctr Ljubljana, Dept Vasc Dis, Ljubljana, Slovenia.
   [Novakovic, Marko; Jug, Borut] Univ Ljubljana, Fac Med, Ljubljana, Slovenia.
   [Lenasi, Helena] Univ Ljubljana, Inst Physiol, Fac Med, Zaloska 4, SI-1000 Ljubljana, Slovenia.
C3 University Medical Centre Ljubljana; University of Ljubljana; University
   of Ljubljana
RP Lenasi, H (corresponding author), Univ Ljubljana, Inst Physiol, Fac Med, Zaloska 4, SI-1000 Ljubljana, Slovenia.
EM helena.lenasi.ml@mf.uni-lj.si
RI Jug, Borut/AAY-6226-2020
OI Jug, Borut/0000-0001-6015-2127; lenasi, helena/0000-0002-2032-725X
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NR 118
TC 15
Z9 18
U1 1
U2 27
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1708-5381
EI 1708-539X
J9 VASCULAR
JI Vascular
PD AUG
PY 2017
VL 25
IS 4
BP 412
EP 422
DI 10.1177/1708538116678752
PG 11
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA FA8UT
UT WOS:000405722400012
PM 28256934
DA 2025-06-11
ER

PT J
AU Tian, JB
   Zhong, R
   Liu, C
   Tang, YH
   Gong, J
   Chang, J
   Lou, J
   Ke, JT
   Li, JY
   Zhang, Y
   Yang, Y
   Zhu, Y
   Gong, YJ
   Xu, YY
   Liu, PY
   Yu, X
   Xiao, L
   Du, M
   Yang, L
   Yuan, J
   Wang, YJ
   Chen, WH
   Wei, S
   Liang, Y
   Zhang, XM
   He, MA
   Wu, TC
   Yao, P
   Miao, XP
AF Tian, Jianbo
   Zhong, Rong
   Liu, Cheng
   Tang, Yuhan
   Gong, Jing
   Chang, Jiang
   Lou, Jiao
   Ke, Juntao
   Li, Jiaoyuan
   Zhang, Yi
   Yang, Yang
   Zhu, Ying
   Gong, Yajie
   Xu, Yanyan
   Liu, Peiyi
   Yu, Xiao
   Xiao, Lin
   Du, Min
   Yang, Ling
   Yuan, Jing
   Wang, Youjie
   Chen, Weihong
   Wei, Sheng
   Liang, Yuan
   Zhang, Xiaomin
   He, Meian
   Wu, Tangchun
   Yao, Ping
   Miao, Xiaoping
TI Association between bilirubin and risk of Non-Alcoholic Fatty Liver
   Disease based on a prospective cohort study
SO SCIENTIFIC REPORTS
LA English
DT Article
ID CARDIOVASCULAR-DISEASE; UNCONJUGATED BILIRUBIN; CONFERS SUSCEPTIBILITY;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; OXIDATIVE STRESS;
   STEATOHEPATITIS; HYPERBILIRUBINEMIA; ANTIOXIDANT; PNPLA3
AB The study aimed to assess the association between total, direct, and indirect bilirubin and nonalcoholic fatty live disease (NAFLD) risk given its high prevalence and serious clinical prognosis. Among 27,009 subjects who participated in a healthy screening program from the Dongfeng-Tongji cohort study in 2008, 8189 eligible subjects (aged 35-86 years; males, 43.95%) were ultimately enrolled. The incidence rates of NAFLD in 2013 were compared with respect to baseline bilirubin levels among subjects free of NAFLD, and the effect sizes were estimated by logistic regression analysis. During 5 years follow-up, we observed 1956 cases of newly developed NAFLD with the overall incidence of 23.88%. Direct bilirubin was presented to inversely associate with NAFLD risk. Compared with quartile 1 of direct bilirubin, the multivariable-adjusted ORs (95% CIs) for NAFLD of quartile 2 to 4 were 1.104 (0.867-1.187), 0.843 (0.719-0.989), and 0.768 (0.652-0.905), respectively, P for trend 0.002). Similarly, inverse effects of direct bilirubin on NAFLD incidence were also observed when stratified by sex and BMI. However, no significant associations were found between total, and indirect bilirubin and NAFLD risk. Direct bilirubin reduced NAFLD risk independent of possible confounders among middle-aged and elderly Chinese population, probably based on the endogenous antioxidation of bilirubin.
C1 [Tian, Jianbo; Zhong, Rong; Liu, Cheng; Gong, Jing; Chang, Jiang; Lou, Jiao; Ke, Juntao; Li, Jiaoyuan; Zhang, Yi; Yang, Yang; Zhu, Ying; Gong, Yajie; Wei, Sheng; Miao, Xiaoping] Huazhong Univ Sci & Technol, Dept Epidemiol & Biostat, Sch Publ Hlth, Tongji Med Coll, 13 Hangkong Rd, Wuhan, Hubei, Peoples R China.
   [Tian, Jianbo; Zhong, Rong; Liu, Cheng; Tang, Yuhan; Gong, Jing; Chang, Jiang; Lou, Jiao; Ke, Juntao; Li, Jiaoyuan; Zhang, Yi; Yang, Yang; Zhu, Ying; Gong, Yajie; Xu, Yanyan; Liu, Peiyi; Yu, Xiao; Xiao, Lin; Du, Min; Yuan, Jing; Chen, Weihong; Wei, Sheng; Liang, Yuan; Zhang, Xiaomin; He, Meian; Wu, Tangchun; Yao, Ping; Miao, Xiaoping] Huazhong Univ Sci & Technol, Minist Educ, Sch Publ Hlth, Tongji Med Coll,Key Lab Environm & Hlth, 13 Hangkong Rd, Wuhan 430030, Hubei, Peoples R China.
   [Tang, Yuhan; Xu, Yanyan; Liu, Peiyi; Yu, Xiao; Xiao, Lin; Du, Min; Yao, Ping] Huazhong Univ Sci & Technol, Hubei Key Lab Food Nutr & Safety, Sch Publ Hlth, Dept Nutr & Food Hyg,Tongji Med Coll, 13 Hangkong Rd, Wuhan, Hubei, Peoples R China.
   [Yang, Ling] Huazhong Univ Sci & Technol, Dept Internal Med, Tongji Med Coll, Div Gastroenterol,Union Hosp, Wuhan, Hubei Province, Peoples R China.
   [Yuan, Jing; Chen, Weihong; Liang, Yuan; Zhang, Xiaomin; He, Meian; Wu, Tangchun] Huazhong Univ Sci & Technol, Inst Occupat Med, Sch Publ Hlth, Tongji Med Coll, 13 Hangkong Rd, Wuhan 430030, Hubei, Peoples R China.
   [Wang, Youjie] Huazhong Univ Sci & Technol, Sch Publ Hlth, Dept Maternal & Child Hlth, Tongji Med Coll, 13 Hangkong Rd, Wuhan 430030, Peoples R China.
C3 Huazhong University of Science & Technology; Ministry of Education -
   China; Huazhong University of Science & Technology; Huazhong University
   of Science & Technology; Huazhong University of Science & Technology;
   Huazhong University of Science & Technology; Huazhong University of
   Science & Technology
RP Miao, XP (corresponding author), Huazhong Univ Sci & Technol, Dept Epidemiol & Biostat, Sch Publ Hlth, Tongji Med Coll, 13 Hangkong Rd, Wuhan, Hubei, Peoples R China.; Yao, P; Miao, XP (corresponding author), Huazhong Univ Sci & Technol, Minist Educ, Sch Publ Hlth, Tongji Med Coll,Key Lab Environm & Hlth, 13 Hangkong Rd, Wuhan 430030, Hubei, Peoples R China.; Yao, P (corresponding author), Huazhong Univ Sci & Technol, Hubei Key Lab Food Nutr & Safety, Sch Publ Hlth, Dept Nutr & Food Hyg,Tongji Med Coll, 13 Hangkong Rd, Wuhan, Hubei, Peoples R China.
EM yaoping@mails.tjmu.cn; miaoxp@mail.hust.edu.cn
RI yang, lu/LUZ-3959-2024; li, yan/GXH-7943-2022; 李, 娇元/GVS-6952-2022;
   Tian, Jianbo/IQS-4466-2023; Liu, Haocheng/HLG-7944-2023; wei,
   sheng/E-9746-2012; Zhong, Rong/Q-1813-2019; gong, jing/LBH-0286-2024;
   Zhang, Xiaomin/F-3206-2018; miao, xiaoping/C-4336-2011
OI miao, xiaoping/0000-0002-6818-9722
FU National Program for Support of Top-notch Young Professionals; 111
   Project [B12004]; Program for Changjiang Scholars; Innovative Research
   Team in University of Ministry of Education of China [IRT1246]; China
   Medical Board [12-113]; National Natural Science Foundation of China
   [81472979, 81402673]
FX We would like to acknowledge all the investigators of the original study
   as well as all study individuals enrolled in the present study. This
   study was supported by the grant from the National Program for Support
   of Top-notch Young Professionals for Xiaoping Miao, the 111 Project (No.
   B12004), the Program for Changjiang Scholars, Innovative Research Team
   in University of Ministry of Education of China (No. IRT1246), China
   Medical Board (No. 12-113), National Natural Science Foundation of China
   (Nos 81472979 and 81402673).
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NR 53
TC 41
Z9 43
U1 0
U2 18
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD AUG 3
PY 2016
VL 6
AR 31006
DI 10.1038/srep31006
PG 9
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA DS3BJ
UT WOS:000380657600002
PM 27484402
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Matsuda, A
   Makino, N
   Tozawa, T
   Shirahata, N
   Honda, T
   Ikeda, Y
   Sato, H
   Ito, M
   Kakizaki, Y
   Akamatsu, M
   Ueno, Y
   Kawata, S
AF Matsuda, Akiko
   Makino, Naohiko
   Tozawa, Tomohiro
   Shirahata, Nakao
   Honda, Teiichiro
   Ikeda, Yushi
   Sato, Hideyuki
   Ito, Miho
   Kakizaki, Yasuharu
   Akamatsu, Manabu
   Ueno, Yoshiyuki
   Kawata, Sumio
TI Pancreatic Fat Accumulation, Fibrosis, and Acinar Cell Injury in the
   Zucker Diabetic Fatty Rat Fed a Chronic High-Fat Diet
SO PANCREAS
LA English
DT Article
DE exocrine pancreas; ZDF rats; high-fat diet; fat accumulation; fibrosis;
   acinar cell injury
ID BETA-CELL; INSULIN-RESISTANCE; METABOLIC SYNDROME; OXIDATIVE STRESS;
   LIVER-DISEASE; LEPTIN; OBESE; MODEL; MASS; AGE
AB Objective: The histological alteration of the exocrine pancreas in obesity has not been clarified. In the present study, we investigated biochemical and histological changes in the exocrine pancreas of obese model rats.
   Methods: Zucker lean rats were fed a standard diet, and Zucker diabetic fatty (ZDF) rats were divided into 2 groups fed a standard diet and a high-fat diet, respectively. These experimental groups were fed each of the diets from 6 weeks until 12, 18, 24 weeks of age. We performed blood biochemical assays and histological analysis of the pancreas.
   Results: In the ZDF rats fed a high-fat diet, the ratio of accumulated pancreatic fat area relative to exocrine gland area was increased significantly at 18 weeks of age in comparison with the other 2 groups (P < 0.05), and lipid droplets were observed in acinar cells. Subsequently, at 24 weeks of age in this group, pancreatic fibrosis and the serum exocrine pancreatic enzyme levels were increased significantly relative to the other 2 groups (P < 0.01).
   Conclusions: In ZDF rats fed a chronic high-fat diet, fat accumulates in pancreatic acinar cells, and this fatty change seems to be related to subsequent pancreatic fibrosis and acinar cell injury.
C1 [Matsuda, Akiko; Makino, Naohiko; Tozawa, Tomohiro; Shirahata, Nakao; Honda, Teiichiro; Ikeda, Yushi; Sato, Hideyuki; Ito, Miho; Kakizaki, Yasuharu; Akamatsu, Manabu; Ueno, Yoshiyuki] Yamagata Univ, Dept Gastroenterol, Fac Med, Yamagata 9909585, Japan.
   [Kawata, Sumio] Hyogo Prefectural Nishinomiya Hosp, Nishinomiya, Hyogo, Japan.
C3 Yamagata University
RP Makino, N (corresponding author), Yamagata Univ, Dept Gastroenterol, Fac Med, 2-2-2 Iida Nishi, Yamagata 9909585, Japan.
EM namakino@med.id.yamagata-u.ac.jp
RI Ueno, Yoshiyuki/R-9242-2019
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NR 54
TC 63
Z9 68
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0885-3177
EI 1536-4828
J9 PANCREAS
JI Pancreas
PD JUL
PY 2014
VL 43
IS 5
BP 735
EP 743
DI 10.1097/MPA.0000000000000129
PG 9
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA AK0UY
UT WOS:000338132700010
PM 24717823
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Zhang, XG
   McGeoch, SC
   Megson, IL
   MacRury, SM
   Johnstone, AM
   Abraham, P
   Pearson, DWM
   de Roos, B
   Holtrop, G
   O'Kennedy, N
   Lobley, GE
AF Zhang, Xuguang
   McGeoch, Susan C.
   Megson, Ian L.
   MacRury, Sandra M.
   Johnstone, Alexandra M.
   Abraham, Prakash
   Pearson, Donald W. M.
   de Roos, Baukje
   Holtrop, Grietje
   O'Kennedy, Niamh
   Lobley, Gerald E.
TI Oat-enriched diet reduces inflammatory status assessed by circulating
   cell-derived microparticle concentrations in type 2 diabetes
SO MOLECULAR NUTRITION & FOOD RESEARCH
LA English
DT Article
DE Microparticles; Oats; Platelets; Standard dietary advice; Type 2
   diabetes
ID GLYCEMIC INDEX DIET; ATOMIC-FORCE MICROSCOPY; ENDOTHELIAL
   MICROPARTICLES; OXIDATIVE STRESS; TISSUE-FACTOR; POSTPRANDIAL
   HYPERGLYCEMIA; PLATELET MICROPARTICLES; METABOLIC SYNDROME; ELEVATED
   LEVELS; LIPID PROFILE
AB Scope: Inflammatory status can increase the risk of adverse cardiovascular events linked to platelet activity and involvement of microparticles (MP) released from platelets (PMP), leukocytes (LMP), and monocytes (MMP). These MP carry host cell-derived antigens that may act as markers of metabolic health. Subjects newly diagnosed with type 2 diabetes are offered appropriate standard dietary advice (SDA) but this may not be optimal as specific inclusion of other nutrients, such as oats, may add benefit. The effectiveness of such interventions can be tested by examination of MP activation markers.
   Methods and results: Subjects (n = 22) with type 2 diabetes participated in a randomized cross-over trial involving 8 wk interventions with either an oat-enriched diet (OAT) or following reinforced SDA. Responses were also compared with preintervention habitual (HAB) intake. OAT reduced the concentrations and proportions of fibrinogen-and tissue factor-related PMP and MMP_11b. The main effect of SDA was to reduce fibrinogen-activated PMP. Regardless of chronic intake, a healthy test meal led to postprandial declines in total PMP as well as tissue factor-, fibrinogen-, and P-selectin-positive PMP.
   Conclusion: OAT improved risk factors assessed by MP status, even in subjects with type 2 diabetes already well-controlled by diet and life-style alone.
C1 [Zhang, Xuguang; Johnstone, Alexandra M.; de Roos, Baukje; Lobley, Gerald E.] Univ Aberdeen, Rowett Inst Nutr & Hlth, Obes & Metab Hlth Div, Aberdeen AB21 9SB, Scotland.
   [Zhang, Xuguang; O'Kennedy, Niamh] Provexis PLC, Rowett Inst Nutr & Hlth, Aberdeen, Scotland.
   [McGeoch, Susan C.; Abraham, Prakash; Pearson, Donald W. M.] Aberdeen Royal Infirm, Aberdeen, Scotland.
   [Megson, Ian L.; MacRury, Sandra M.] Univ Highlands & Isl, Dept Diabet & Cardiovasc Sci, Inverness, Scotland.
   [Holtrop, Grietje] Biomath & Stat Scotland, Aberdeen, Scotland.
C3 University of Aberdeen; University of Aberdeen; University of Aberdeen;
   University of the Highlands & Islands; James Hutton Institute
RP Lobley, GE (corresponding author), Univ Aberdeen, Rowett Inst Nutr & Hlth, Greenburn Rd, Aberdeen AB21 9SB, Scotland.
EM g.lobley@abdn.ac.uk
RI Holtrop, Grietje/J-6061-2013; Megson, Ian/K-2195-2012
OI Johnstone, Alexandra/0000-0002-5484-292X; de Roos,
   Baukje/0000-0002-2750-3914; Megson, Ian/0000-0001-8287-2459
FU Chief Scientists Office of the Scottish Government; Provexis plc.
FX This work was funded by the Chief Scientists Office of the Scottish
   Government by a joint grant to the University of the Highland and
   Islands, Grampian Health Board, Biomathematics and Statistics Scotland
   and the Rowett Institute of Nutrition and Health, University of
   Aberdeen. Additional support was provided by Provexis plc.
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NR 71
TC 35
Z9 36
U1 0
U2 17
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1613-4125
EI 1613-4133
J9 MOL NUTR FOOD RES
JI Mol. Nutr. Food Res.
PD JUN
PY 2014
VL 58
IS 6
BP 1322
EP 1332
DI 10.1002/mnfr.201300820
PG 11
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA AJ4XQ
UT WOS:000337683500016
PM 24604886
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Tam, HK
   Kelly, AS
   Metzig, AM
   Steinberger, J
   Johnson, LA
AF Tam, Harrison K.
   Kelly, Aaron S.
   Metzig, Andrea M.
   Steinberger, Julia
   Johnson, L'Aurelle A.
TI Xanthine Oxidase and Cardiovascular Risk in Obese Children
SO CHILDHOOD OBESITY
LA English
DT Article
ID SERUM URIC-ACID; CIRCULATING OXIDIZED LDL; ENDOTHELIAL DYSFUNCTION;
   METABOLIC SYNDROME; INSULIN-RESISTANCE; ATHEROSCLEROSIS; INFLAMMATION;
   ALLOPURINOL; ADIPONECTIN; INHIBITION
AB Background: Pathological mechanisms of how childhood obesity leads to increased risk of cardiovascular disease (CVD) are not fully characterized. Oxidative-stress-related enzymes, such as xanthine oxidase (XO), have been linked to obesity, endothelial dysfunction, and CVD in adults, but little is known about this pathway in children. The aim of this study was to determine whether differential XO activity is associated with endothelial dysfunction, CVD risk factors, or cytokine levels.
   Methods: Fasting plasma samples were obtained from obese (BMI >= 95th percentile; n = 20) and age-and gender-matched healthy weight (BMI > 5th and < 85th percentile; n = 22) children and adolescents (mean age, 12 +/- 3 years) to quantify XO activity. In addition, fasting cholesterol, insulin, glucose, blood pressure, endothelial function, and cytokine levels were assessed.
   Results: We observed a 3.8-fold increase in plasma XO activity in obese, compared to healthy weight, children (118 +/- 21 vs. 31 +/- 9 nU/mg of protein; p < 0.001). Plasma XO activity was correlated with BMI z-score (r = 0.41), waist circumference (r = 0.41), high-density lipoprotein cholesterol (r= -0.32), oxidized low-density lipoprotein (r = 0.57), adiponectin (r= -0.53), and monocyte chemotactic protein-1 (r= -0.59).
   Conclusion: XO activity is highly elevated in obese children and correlates with CVD risk factors, suggesting that XO may play a role in increasing cardiovascular risk early in life in the context of obesity.
C1 [Tam, Harrison K.; Johnson, L'Aurelle A.] Univ Minnesota, Coll Pharm, Dept Expt & Clin Pharmacol, Minneapolis, MN 55455 USA.
   [Kelly, Aaron S.; Metzig, Andrea M.; Steinberger, Julia; Johnson, L'Aurelle A.] Univ Minnesota, Sch Med, Dept Pediat, Minneapolis, MN 55455 USA.
C3 University of Minnesota System; University of Minnesota Twin Cities;
   University of Minnesota System; University of Minnesota Twin Cities
RP Johnson, LA (corresponding author), Univ Minnesota, Coll Pharm, Dept Expt & Clin Pharmacol, 308 Harvard St SE,7-115C WDH, Minneapolis, MN 55455 USA.
EM Joh02745@umn.edu
OI Steinberger, Julia/0000-0002-2892-8594
FU Children's Cancer Research Fund of Minneapolis, Minnesota [K12
   HD052187-01]; National Institutes of Health (NIH) [1R01DK072124-01A3];
   University of Minnesota Vikings Children's Fund; Minnesota Medical
   Foundation; Minnesota Obesity Center; GCRC [M01-RR00400]; General
   Clinical Research Center Program; National Center for Research
   Resources/NIH
FX This research was supported by the Children's Cancer Research Fund of
   Minneapolis, Minnesota (to L.A.J), K12 HD052187-01 (to L.A.J.), the
   National Institutes of Health (NIH; 1R01DK072124-01A3; to A. K.), the
   University of Minnesota Vikings Children's Fund (to A. K.), the
   Minnesota Medical Foundation (to A. K.), the Minnesota Obesity Center
   (to A. K.), GCRC (M01-RR00400), the General Clinical Research Center
   Program (to A. K.), and the National Center for Research Resources/NIH
   (to A.K.).
CR Bo S, 2008, J ENDOCRINOL INVEST, V31, P499, DOI 10.1007/BF03346397
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NR 28
TC 22
Z9 23
U1 0
U2 4
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 2153-2168
EI 2153-2176
J9 CHILD OBES
JI Child Obes.
PD APR
PY 2014
VL 10
IS 2
BP 175
EP 180
DI 10.1089/chi.2013.0098
PG 6
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA AI5GD
UT WOS:000336892500011
PM 24568669
OA Green Published
DA 2025-06-11
ER

PT J
AU Lim, SG
   Han, K
   Kim, HA
   Pyo, SW
   Cho, YS
   Kim, KS
   Yim, HW
   Lee, WC
   Park, YG
   Park, YM
AF Lim, Sang Gyu
   Han, Kyungdo
   Kim, Hyun-Ah
   Pyo, Sung Woon
   Cho, Young-Sik
   Kim, Kyung-Soo
   Yim, Hyeon Woo
   Lee, Won-Chul
   Park, Yong Gyu
   Park, Yong-Moon
TI Association between insulin resistance and periodontitis in Korean
   adults
SO JOURNAL OF CLINICAL PERIODONTOLOGY
LA English
DT Article
DE Insulin resistance; periodontitis; menopause
ID HOMEOSTASIS MODEL ASSESSMENT; C-REACTIVE PROTEIN; METABOLIC SYNDROME;
   SYSTEMIC INFLAMMATION; OXIDATIVE STRESS; UNITED-STATES; NORMAL-WEIGHT;
   DISEASE; RISK; POPULATION
AB ObjectiveRecent studies have proposed an association between periodontitis and metabolic abnormalities. We investigated the association between insulin resistance and periodontitis among Korean adults.
   MethodsA cross-sectional analysis was conducted using the Korea National Health and Nutrition Examination Survey 2008-2010. A total of 16,720 non-diabetic subjects over 18years old were evaluated (7060 men and 9660 women). Periodontal status was assessed by the Community Periodontal Index. Insulin resistance was measured using the homeostasis model assessment of insulin resistance (HOMA-IR). Participants in the highest and lowest quartile of HOMA-IR were defined as insulin-resistant and insulin-sensitive respectively.
   ResultsThe prevalence of periodontitis increased significantly with higher HOMA-IR quartiles in post-menopausal women (p for linear association=0.019). Among post-menopausal women, participants in the highest quartile of HOMA-IR were significantly more likely to have periodontitis compared to those in the lowest quartile [adjusted odds ratio (OR), 1.47; 95% confidence interval (CI), 1.07-2.01]. Moreover, obese post-menopausal women showed an increased association between insulin resistance and periodontitis (adjusted OR, 1.92; 95% CI,1.29-2.87). However, this association was not found in men or pre-menopausal women.
   ConclusionsOur results suggest that insulin resistance may be associated with periodontitis, especially when combined with obesity, among post-menopausal women in Korea.
C1 [Lim, Sang Gyu; Yim, Hyeon Woo; Lee, Won-Chul; Park, Yong-Moon] Catholic Univ Korea, Grad Sch Publ Hlth, Seoul 13770, South Korea.
   [Lim, Sang Gyu; Pyo, Sung Woon] Catholic Univ Korea, Dept Dent, Coll Med, Seoul 13770, South Korea.
   [Han, Kyungdo; Park, Yong Gyu] Catholic Univ Korea, Dept Biostat, Coll Med, Seoul 13770, South Korea.
   [Han, Kyungdo; Yim, Hyeon Woo; Lee, Won-Chul; Park, Yong-Moon] Catholic Univ Korea, Coll Med, Dept Prevent Med, Seoul 13770, South Korea.
   [Kim, Hyun-Ah] Catholic Univ Korea, Catholic Med Ctr, Seoul 13770, South Korea.
   [Cho, Young-Sik] Namseoul Univ, Dept Dent Hyg, Cheonan, South Korea.
   [Kim, Kyung-Soo] Catholic Univ Korea, Coll Med, Dept Family Med, Seoul 13770, South Korea.
   [Park, Yong-Moon] Univ S Carolina, Arnold Sch Publ Hlth, Dept Epidemiol & Biostat, Columbia, SC 29208 USA.
C3 Catholic University of Korea; Catholic University of Korea; Catholic
   University of Korea; Catholic University of Korea; Catholic University
   of Korea; Namseoul University; Catholic University of Korea; University
   of South Carolina System; University of South Carolina Columbia
RP Park, YM (corresponding author), Catholic Univ Korea, Coll Med, Dept Prevent Med, 222 Banpo Daero, Seoul 13770, South Korea.
EM markYMpark@gmail.com
RI PARK, YONG-MOON ("MARK")/ABA-2765-2021
OI PARK, YONG-MOON ("MARK")/0000-0002-5879-6879; Park, Yong
   Gyu/0000-0002-8721-3230
FU Catholic Medical Center Research Foundation
FX This study was funded by research grants from the Catholic Medical
   Center Research Foundation in 2011.
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NR 48
TC 37
Z9 45
U1 0
U2 11
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0303-6979
EI 1600-051X
J9 J CLIN PERIODONTOL
JI J. Clin. Periodontol.
PD FEB
PY 2014
VL 41
IS 2
BP 121
EP 130
DI 10.1111/jcpe.12196
PG 10
WC Dentistry, Oral Surgery & Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dentistry, Oral Surgery & Medicine
GA 287YU
UT WOS:000329579300004
PM 24303984
DA 2025-06-11
ER

PT J
AU Bloch, W
   Zopf, E
   Zimmer, P
   Baumann, FT
AF Bloch, Wilhelm
   Zopf, Eva
   Zimmer, Philipp
   Baumann, Freerk T.
TI Role of physical activity in tumor patients and possible underlying
   mechanisms
SO EUROPEAN REVIEW OF AGING AND PHYSICAL ACTIVITY
LA English
DT Review
DE Resistance training; Endurance training; Epigenetic; Inflammation;
   Cachexia; Fatigue
ID RANDOMIZED CONTROLLED-TRIAL; CHRONIC-FATIGUE-SYNDROME; BREAST-CANCER
   SURVIVORS; SKELETAL-MUSCLE; OXIDATIVE STRESS; RESISTANCE EXERCISE;
   AEROBIC EXERCISE; HISTONE MODIFICATIONS; RADIATION-THERAPY;
   BODY-COMPOSITION
AB A growing knowledge regarding the influence of exercise on adverse physiologic outcomes associated with cancer and its treatment exists. Aside from its effects on psychological behavior, quality of life, and cancer-related fatigue, physical exercise can target physical and cardio-respiratory fitness, insulin regulation and metabolic syndrome, body weight and composition, and immune function in tumor patients. The increasing number of study results for different cancer types, which prove the positive influences of physical activity in cancer patients, changed the contradictory opinions which existed until the end of the last century. Although an increasing number of studies showing the positive effects of physical activity and more specifically of endurance and resistance training in cancer patients have been published, the underlying mechanisms are mostly unknown. Thus, we summarized the current knowledge of the effects of physical activity and specific training in different tumor entities with specific respect to the possible underlying mechanisms. Especially, the association between physical activity and (1) the improvement of fatigue and the role of free radicals in this process, (2) the counterbalance of tumor-induced cachexia, (3) the improvement of the immune system for supportive tumor treatment, and (4) the possible role of epigenetic modulation against tumor and tumor treatment-dependent adverse physiologic outcomes is focused.
C1 [Bloch, Wilhelm; Zopf, Eva; Zimmer, Philipp; Baumann, Freerk T.] German Sport Univ Cologne, Inst Cardiol & Sports Med, Dept Mol & Cellular Sports Med, Sportpk Mungersdorf 6, D-50933 Cologne, Germany.
C3 German Sport University Cologne
RP Bloch, W (corresponding author), German Sport Univ Cologne, Inst Cardiol & Sports Med, Dept Mol & Cellular Sports Med, Sportpk Mungersdorf 6, D-50933 Cologne, Germany.
EM W.bloch@dshs-koeln.de
RI Zopf, Eva Maria/M-1697-2018
OI Zopf, Eva Maria/0000-0001-6250-0041
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NR 88
TC 4
Z9 6
U1 0
U2 45
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1813-7253
EI 1861-6909
J9 EUR REV AGING PHYS A
JI Eur. Rev. Aging Phys. Act.
PD APR
PY 2013
VL 10
IS 1
BP 25
EP 32
DI 10.1007/s11556-012-0106-4
PG 8
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA 109GT
UT WOS:000316355300006
OA hybrid
DA 2025-06-11
ER

PT J
AU Lacroix, M
   Gaudichon, C
   Martin, A
   Morens, C
   Mathé, V
   Tomé, D
   Huneau, JF
AF Lacroix, M
   Gaudichon, C
   Martin, A
   Morens, C
   Mathé, V
   Tomé, D
   Huneau, JF
TI A long-term high-protein diet markedly reduces adipose tissue without
   major side effects in Wistar male rats
SO AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE
   PHYSIOLOGY
LA English
DT Article
DE hormones; glucose; body composition; histology
ID AMINO-ACID INFUSION; LOW-FAT DIETS; WEIGHT-LOSS; LIPID CONCENTRATIONS;
   INSULIN SENSITIVITY; RANDOMIZED-TRIAL; BODY-COMPOSITION; GLYCEMIC
   CONTROL; HEALTHY-ADULTS; ENERGY-BALANCE
AB Although there is a considerable interest of high-protein, low-carbohydrate diets to manage weight control, their safety is still the subject of considerable debate. They are suspected to be detrimental to the renal and hepatic functions, calcium balance, and insulin sensitivity. However, the long-term effects of a high-protein diet on a broad range of parameters have not been investigated. We studied the effects of a high-protein diet in rats over a period of 6 mo. Forty-eight Wistar male rats received either a normal-protein (NP: 14% protein) or high-protein ( HP: 50% protein) diet. Detailed body composition, plasma hormones and nutrients, liver and kidney histopathology, hepatic markers of oxidative stress and detoxification, and the calcium balance were investigated. No major alterations of the liver and kidneys were found in HP rats, whereas NP rats exhibited massive hepatic steatosis. The calcium balance was unchanged, and detoxification markers (GSH and GST) were enhanced moderately in the HP group. In contrast, HP rats showed a sharp reduction in white adipose tissue and lower basal concentrations of triglycerides, glucose, leptin, and insulin. Our study suggests that the long-term consumption of an HP diet in male rats has no deleterious effects and could prevent metabolic syndrome.
C1 Inst Natl Agron Paris Grignon, INRA, Unite Physiol Nutr & Comportement Alimentaire 914, F-75231 Paris 05, France.
   Hop Avicenne, Serv Anat Pathol, F-93000 Bobigny, France.
C3 INRAE; Universite Paris Saclay; AgroParisTech; Universite Paris 13;
   Assistance Publique Hopitaux Paris (APHP); Hopital Universitaire
   Avicenne - APHP
RP Inst Natl Agron Paris Grignon, INRA, Unite Physiol Nutr & Comportement Alimentaire 914, F-75231 Paris 05, France.
EM gaudicho@inapg.inra.fr
OI GAUDICHON, Claire/0000-0002-0983-4760
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NR 75
TC 124
Z9 136
U1 1
U2 19
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0363-6119
EI 1522-1490
J9 AM J PHYSIOL-REG I
JI Am. J. Physiol.-Regul. Integr. Comp. Physiol.
PD OCT
PY 2004
VL 287
IS 4
BP R934
EP R942
DI 10.1152/ajpregu.00100.2004
PG 9
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA 854ES
UT WOS:000223884500031
PM 15155276
DA 2025-06-11
ER

PT J
AU Haider, A
   Bengs, S
   Maredziak, M
   Messerli, M
   Fiechter, M
   Giannopoulos, AA
   Treyer, V
   Schwyzer, M
   Kamani, CH
   Patriki, D
   von Felten, E
   Benz, DC
   Fuchs, TA
   Gräni, C
   Pazhenkottil, AP
   Kaufmann, PA
   Buechel, RR
   Gebhard, C
AF Haider, Achi
   Bengs, Susan
   Maredziak, Monika
   Messerli, Michael
   Fiechter, Michael
   Giannopoulos, Andreas A.
   Treyer, Valerie
   Schwyzer, Moritz
   Kamani, Christel Hermann
   Patriki, Dimitri
   von Felten, Elia
   Benz, Dominik C.
   Fuchs, Tobias A.
   Grani, Christoph
   Pazhenkottil, Aju P.
   Kaufmann, Philipp A.
   Buechel, Ronny R.
   Gebhard, Catherine
TI Heart rate reserve during pharmacological stress is a significant
   negative predictor of impaired coronary flow reserve in women
SO EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
LA English
DT Article
DE N-13-ammonia PET; Coronary artery disease; Women; Adenosine; Heart rate
   reserve
ID POSITRON-EMISSION-TOMOGRAPHY; CARDIAC SYNDROME-X; ARTERY-DISEASE; RATE
   RESPONSE; COMPUTED-TOMOGRAPHY; MICROVASCULAR DYSFUNCTION; DIAGNOSTIC
   PERFORMANCE; MAGNETIC-RESONANCE; PROGNOSTIC VALUE; ADENOSINE
AB PurposeEvidence to date has failed to adequately explore determinants of cardiovascular risk in women with coronary microvascular dysfunction (CMVD). Heart rate responses to adenosine mirror autonomic activity and may carry important prognostic information for the diagnosis of CMVD.MethodsHemodynamic changes during adenosine stress were analyzed in a propensity-matched cohort of 404 patients (202 women, mean age 65.911.0) who underwent clinically indicated myocardial perfusion N-13-ammonia Positron-Emission-Tomography (PET) at our institution between September 2013 and May 2017.ResultsBaseline heart rate (HR) was significantly higher in patients with abnormal coronary flow reserve (CFR, p<0.001 vs normal CFR). Accordingly, a blunted HR response to adenosine (=reduced heart rate reserve, %HRR) was seen in patients with abnormal CFR, with a most pronounced effect being observed in female patients free of myocardial ischemia (45.9 +/- 34.9 vs 26.5 +/- 18.0, p<0.001 in women and 29.1 +/- 16.9 vs 24.3 +/- 21.7, p=0.15 in men). Hence, a fully-adjusted multivariate logistic regression model identified HRR as the strongest negative predictor of reduced CFR in women free of myocardial ischemia, but not in men. Accordingly, receiver operating characteristics (ROC) curves for the presence of reduced CFR revealed that a %HRR <35 was a powerful predictor for abnormal CFR with a sensitivity of 81% and a specificity of 60% in women.Conclusion p id=Par4 A blunted HRR <35% is associated with abnormal CFR in women. Taking into account HR responses during stress test in women may help to risk stratify the heterogeneous female population of patients with non-obstructive coronary artery disease (CAD).
C1 [Haider, Achi; Bengs, Susan; Maredziak, Monika; Messerli, Michael; Fiechter, Michael; Giannopoulos, Andreas A.; Treyer, Valerie; Schwyzer, Moritz; Kamani, Christel Hermann; Patriki, Dimitri; von Felten, Elia; Benz, Dominik C.; Fuchs, Tobias A.; Grani, Christoph; Pazhenkottil, Aju P.; Kaufmann, Philipp A.; Buechel, Ronny R.; Gebhard, Catherine] Univ Hosp Zurich, Dept Nucl Med, Raemistr 100, CH-8091 Zurich, Switzerland.
   [Haider, Achi; Bengs, Susan; Maredziak, Monika; Fiechter, Michael; Gebhard, Catherine] Univ Zurich, Ctr Mol Cardiol, Zurich, Switzerland.
C3 University of Zurich; University Zurich Hospital; University of Zurich
RP Gebhard, C (corresponding author), Univ Hosp Zurich, Dept Nucl Med, Raemistr 100, CH-8091 Zurich, Switzerland.; Gebhard, C (corresponding author), Univ Zurich, Ctr Mol Cardiol, Zurich, Switzerland.
EM Catherine.gebhard@usz.ch
RI Gebhard, Catherine/AAT-7060-2020; Fuchs, Tobias/N-4435-2013; Haider,
   Ahmed/AAQ-6443-2020; Haider, Achi/N-3834-2017; Treyer,
   Valerie/G-6986-2018; Giannopoulos, Andreas/HHS-9077-2022
OI Pazhenkottil, Aju/0000-0002-8847-2154; Buechel, Ronny
   Ralf/0000-0001-8064-8904; Kaufmann, Philipp Antonio/0000-0002-9451-5210;
   Bengs, Susan/0000-0003-2424-3894; Gebhard,
   Catherine/0000-0001-7240-5822; Haider, Achi/0000-0002-5204-4473; Grani,
   Christoph/0000-0001-6029-0597; Treyer, Valerie/0000-0002-4584-3031;
   Giannopoulos, Andreas/0000-0002-0938-3170
FU Swiss National Science Foundation (SNSF); Olga Mayenfisch Foundation,
   Switzerland; OPO Foundation, Switzerland; Novartis Foundation,
   Switzerland; Swissheart Foundation; Helmut Horten Foundation,
   Switzerland; Iten-Kohaut Foundation, Switzerland
FX CG was supported by grants from the Swiss National Science Foundation
   (SNSF); the Olga Mayenfisch Foundation, Switzerland; the OPO Foundation,
   Switzerland; the Novartis Foundation, Switzerland; the Swissheart
   Foundation; and the Helmut Horten Foundation, Switzerland. MM was
   supported by the Iten-Kohaut Foundation, Switzerland.
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NR 44
TC 17
Z9 19
U1 4
U2 9
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1619-7070
EI 1619-7089
J9 EUR J NUCL MED MOL I
JI Eur. J. Nucl. Med. Mol. Imaging
PD JUN
PY 2019
VL 46
IS 6
BP 1257
EP 1267
DI 10.1007/s00259-019-4265-7
PG 11
WC Radiology, Nuclear Medicine & Medical Imaging
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Radiology, Nuclear Medicine & Medical Imaging
GA HV7VK
UT WOS:000466188800011
PM 30648200
DA 2025-06-11
ER

PT J
AU Shi, HY
   Liu, X
   Zhao, PY
   Huang, W
   Wang, HB
   Jin, HY
   Zhu, JY
   Wang, JW
   Li, TJ
AF Shi, Huiyang
   Liu, Xuan
   Zhao, Peiyi
   Huang, Wei
   Wang, Hebin
   Jin, Heying
   Zhu, Junyou
   Wang, Jianwu
   Li, Tianjiao
TI Possibility and Potenzial Intervention Targets of Saffron Extract in the
   Treatment of Atopic Dermatitis: A Review
SO PLANTA MEDICA
LA English
DT Review; Early Access
DE Atopic dermatitis; saffron; Iridaceae; Gardenia; Rubiaceae; crocin;
   crocetin; safranal
ID CROCUS-SATIVUS-L.; GARDENIA-JASMINOIDES ELLIS; CONSTITUENT CROCIN;
   METABOLIC SYNDROME; SAFETY EVALUATION; OXIDATIVE STRESS; CROCETIN
   ESTERS; GUT MICROBIOTA; DOUBLE-BLIND; SKIN
AB Atopic dermatitis (AD) is a chronic, recurrent inflammatory skin disorder characterized by dry skin, eczema-like lesions, and severe itching. The multifaceted etiology of AD, which is not yet fully understood, includes genetic predispositions, immune dysfunctions(such as an impaired skin barrier and abnormal immune regulation), imbalances in the skin microbiota, and environmental factors, among others. In the field of AD treatment, the combination of traditional Chinese medicine and modern medicine is becoming an emerging trend. Given the potenzial side effects and reduced efficacy of conventional therapeutic drugs, Chinese herbal medicines offer patients new treatment options because of their unique efficacy and low toxicity. Some saffron extracts derived from saffron and gardenia, such as crocin, crocetin, and safranal, have shown promising potenzial in the treatment of AD. These natural ingredients not only possess anti-inflammatory and immunomodulatory properties similar to those of traditional Chinese medicines but also demonstrate excellent effects in promoting the repair of damaged skin barriers. Therefore, this article reviews the therapeutic potenzial of saffron extract in the treatment of AD, with a special focus on its mechanisms and potenzial interventions, while emphasizing the importance of herbal medicines as alternatives to traditional treatments, providing AD patients with safer and more effective treatment options.
C1 [Liu, Xuan; Wang, Jianwu; Li, Tianjiao] Cent South Univ, Xiangya Sch Publ Hlth, 172 Tongzipo Rd, Changsha 410078, Hunan, Peoples R China.
   [Shi, Huiyang; Zhao, Peiyi; Huang, Wei; Wang, Hebin; Jin, Heying] Cent South Univ, Xiangya Sch Med, Changsha, Peoples R China.
   [Wang, Jianwu] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Burn Surg, Guangzhou, Peoples R China.
C3 Central South University; Central South University; Sun Yat Sen
   University
RP Wang, JW; Li, TJ (corresponding author), Cent South Univ, Xiangya Sch Publ Hlth, 172 Tongzipo Rd, Changsha 410078, Hunan, Peoples R China.
EM jianwu_wang@csu.edu.cn; tianjiao9896@csu.edu.cn
FU National Science Foundation of China [82102332]; Natural Science
   Foundation of Hunan Province [2022JJ40667, 2022JJ30785]; Graduate
   Student Independent Exploration and Innovation Program of Central South
   University [1053320241380]; China International College Students'
   Innovation Competition [CXPY2024437]; Natural Science Foundation of
   Changsha [kq2202128, kq2202078]
FX The authors are grateful to the National Science Foundation of China
   (Grant No. 82102332), the Natural Science Foundation of Hunan Province
   (Grant Nos. 2022JJ40667 and 2022JJ30785), the Graduate Student
   Independent Exploration and Innovation Program of Central South
   University (1053320241380), the China International College Students'
   Innovation Competition (CXPY2024437), and the Natural Science Foundation
   of Changsha (Grant Nos. kq2202128 and kq2202078).
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NR 174
TC 0
Z9 0
U1 4
U2 4
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA Oswald-Hesse-Strasse 50, D-70469 STUTTGART, GERMANY
SN 0032-0943
EI 1439-0221
J9 PLANTA MED
JI Planta Med.
PD 2025 MAR 20
PY 2025
DI 10.1055/a-2538-5769
EA MAR 2025
PG 15
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA 0IL8L
UT WOS:001448155400001
PM 39947646
DA 2025-06-11
ER

PT J
AU Gentile, JKD
   Migliore, R
   Waisberg, J
   Ribeiro, MAF Jr
AF Gentile, Joao Kleber de Almeida
   Migliore, Renato
   Waisberg, Jaques
   Ribeiro Junior, Marcelo Augusto Fontenelle
TI The Influence of Bariatric Surgery on Matrix Metalloproteinase Plasma
   Levels in Patients with Type 2 Diabetes Mellitus
SO BIOMOLECULES
LA English
DT Article
DE bariatric surgery; morbid obesity; matrix metalloproteinases; gastric
   bypass; gastroplasty; diabetes mellitus
ID ADIPOSE-TISSUE; WEIGHT-LOSS; RISK; MATRIX-METALLOPROTEINASE-9;
   INHIBITORS; DECREASES
AB Background: Bariatric surgery is a safe and effective procedure for treating obesity and metabolic conditions such as type 2 diabetes mellitus (T2DM). Remodeling of the extracellular matrix (ECM) supports adipose tissue expansion and its metabolic activity, where matrix metalloproteinases (MMPs) play a key role in ECM regulation. The MMPs, particularly MMP-2 and MMP-9, are elevated in patients with morbid obesity, metabolic syndrome, and T2DM. Objectives: To evaluate the effect of weight loss in bariatric surgery patients using oxidative stress markers and to compare MMP levels in patients undergoing bariatric surgery. Methods: This was a prospective, controlled study including 45 morbidly obese patients with T2DM (BMI > 35 kg/m(2)) who underwent RYGB (n = 24) or VG (n = 21). Weight loss was assessed through anthropometric measurements (weight, height, BMI). MMP-2 and MMP-9 levels were measured preoperatively and at 3 and 12 months postoperatively. Results: Significant and sustained weight loss was observed after surgery in both groups, with reductions in BMI. MMP-2 and MMP-9 levels decreased significantly after one year of follow-up. Conclusions: Bariatric surgery is an effective long-term intervention for weight loss and associated comorbidities, including T2DM. MMP-2 and MMP-9 proved to be effective markers of extracellular matrix remodeling, with significant reductions following surgery.
C1 [Gentile, Joao Kleber de Almeida] Inst Infectol Emilio Ribas IIER, Dept Surg, BR-01246900 Sao Paulo, SP, Brazil.
   [Migliore, Renato] Hosp Sao Camilo, Dept Surg, BR-02401200 Sao Paulo, SP, Brazil.
   [Waisberg, Jaques] ABC Med Sch, Dept Surg, BR-09060870 Santo Andre, SP, Brazil.
   [Ribeiro Junior, Marcelo Augusto Fontenelle] Univ Maryland, R Adams Cowley Shock Trauma Ctr, Dept Surg, Baltimore, MD 21201 USA.
C3 Faculdade de Medicina do ABC; University System of Maryland; University
   of Maryland Baltimore
RP Gentile, JKD (corresponding author), Inst Infectol Emilio Ribas IIER, Dept Surg, BR-01246900 Sao Paulo, SP, Brazil.
EM joao.gentile@emilioribas.sp.gov.br; renato.migliore@hotmail.com;
   jaqueswaisberg@uol.com.br; drmribeiro@gmail.com
RI Ribeiro Junior, Marcelo/AFS-6590-2022; GENTILE, JOAO/F-8318-2012;
   Waisberg, Jaques/M-6311-2013; Fontenelle Ribeiro Junior, Marcelo
   Augusto/D-9862-2014
OI GENTILE, JOAO/0000-0001-8650-2703; Waisberg, Jaques/0000-0003-2775-8068;
   Fontenelle Ribeiro Junior, Marcelo Augusto/0000-0001-9826-4722
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NR 41
TC 0
Z9 0
U1 0
U2 0
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2218-273X
J9 BIOMOLECULES
JI Biomolecules
PD DEC
PY 2024
VL 14
IS 12
AR 1633
DI 10.3390/biom14121633
PG 10
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA Q8K9G
UT WOS:001387108000001
PM 39766340
OA gold
DA 2025-06-11
ER

PT J
AU Noor, S
   Mohammad, T
   Ashraf, GM
   Farhat, J
   Bilgrami, AL
   Eapen, MS
   Sohal, SS
   Yadav, DK
   Hassan, MI
AF Noor, Saba
   Mohammad, Taj
   Ashraf, Gulam M.
   Farhat, Joviana
   Bilgrami, Anwar L.
   Eapen, Mathew Suji
   Sohal, Sukhwinder Singh
   Yadav, Dharmendra Kumar
   Hassan, Md Imtaiyaz
TI Mechanistic insights into the role of serum-glucocorticoid kinase 1 in
   diabetic nephropathy: A systematic review
SO INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
LA English
DT Review
DE Serum glucocorticoid kinase; Diabetic nephropathy; Hyperglycemia;
   Epithelial sodium channel; Renal fibrosis; Therapeutic targeting
ID EPITHELIAL SODIUM-CHANNEL; INDUCIBLE PROTEIN-KINASE; RENAL
   ISCHEMIA/REPERFUSION INJURY; REGULATED KINASE; OXIDATIVE STRESS; GLUCOSE
   COTRANSPORTER; ANGIOTENSIN-II; ENAC SUBUNITS; SGK1 KINASE; K+ CHANNEL
AB Aberrant expression of serum-glucocorticoid kinase 1 (SGK1) contributes to the pathogenesis of multiple disorders, including diabetes, hypertension, obesity, fibrosis, and metabolic syndrome. SGK1 variant is expressed in the presence of insulin and several growth factors, eventually modulating various ion channels, carrier proteins, and transcription factors. SGK1 also regulates the enzymatic activity of Na+ K+ ATPase, glycogen synthase kinase-3, ubiquitin ligase Nedd4-2, and phosphomannose mutase impacting cell cycle regulation, neuroexcitation, and apoptosis. Ample evidence supports the crucial role of aberrant SGK1 expression in hyperglycemia-mediated secondary organ damage. Diabetic nephropathy (DN), a dreadful microvascular complication of diabetes, is the leading cause of end-stage renal failures with high morbidity and mortality rate. The complex pathogenesis of DN encompasses several influencing factors, including transcriptional factors, inflammatory markers, cytokines, epigenetic modulators, and abnormal enzymatic activities. SGK1 plays a pivotal role by controlling various physiological functions associated with the occurrence and progression of DN; therefore, targeting SGK1 may favorably influence the clinical outcome in patients with DN. This review aimed to provide mechanistic insights into SGK1 regulated DN pathogenesis and summarize the evidence supporting the therapeutic potential of SGK1 inhibition and its consequences on human health.
C1 [Noor, Saba; Mohammad, Taj; Hassan, Md Imtaiyaz] Ctr Interdisciplinary Res Basic Sci, Jamia Millia Islamia, New Delhi 110025, India.
   [Ashraf, Gulam M.] King Abdulaziz Univ, King Fahd Med Res Ctr, Pre Clin Res Unit, Jeddah, Saudi Arabia.
   [Ashraf, Gulam M.] King Abdulaziz Univ, Fac Appl Med Sci, Dept Med Lab Technol, Jeddah, Saudi Arabia.
   [Farhat, Joviana] Al Ain Univ, Coll Pharm, Abu Dhabi 112612, U Arab Emirates.
   [Bilgrami, Anwar L.] King Abdulaziz Univ, Deanship Sci Res, Jeddah, Saudi Arabia.
   [Bilgrami, Anwar L.] Rutgers State Univ, Dept Entomol, New Brunswick, NJ 08901 USA.
   [Eapen, Mathew Suji; Sohal, Sukhwinder Singh] Univ Tasmania, Coll Hlth & Med, Sch Hlth Sci, Resp Translat Res Grp,Dept Lab Med, Launceston, Tas, Australia.
   [Yadav, Dharmendra Kumar] Gachon Univ Med & Sci, Coll Pharm, Incheon 21924, South Korea.
C3 King Abdulaziz University; King Abdulaziz University; King Abdulaziz
   University; Rutgers University System; Rutgers University New Brunswick;
   University of Tasmania; Gachon University
RP Hassan, MI (corresponding author), Ctr Interdisciplinary Res Basic Sci, Jamia Millia Islamia, New Delhi 110025, India.; Yadav, DK (corresponding author), Gachon Univ Med & Sci, Coll Pharm, Incheon 21924, South Korea.
EM dharmendra@gachon.ac.kr; mihassan@jmi.ac.in
RI Sohal, Sukhwinder/J-7395-2014; Yadav, Dharmendra/P-9999-2019; Yadav,
   Dharmendra Kumar/L-1846-2015; Ashraf, Ghulam Md/H-9485-2012; Mohammad,
   Taj/HJH-1874-2023; Hassan, Md. Imtaiyaz/G-7072-2017
OI Yadav, Dharmendra Kumar/0000-0003-1102-1993; Ashraf, Ghulam
   Md/0000-0002-9820-2078; Mohammad, Taj/0000-0002-0399-4835; Sohal,
   Sukhwinder Singh/0000-0001-9627-6498; Hassan, Md.
   Imtaiyaz/0000-0002-3663-4940
FU Indian Council of Medical Research, Government of India [ISRM/12 [22]
   /2020]
FX This work is supported by grants from the Indian Council of Medical
   Research, Government of India (Grant No. ISRM/12 [22] /2020) .
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NR 169
TC 11
Z9 12
U1 1
U2 24
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0141-8130
EI 1879-0003
J9 INT J BIOL MACROMOL
JI Int. J. Biol. Macromol.
PD DEC 15
PY 2021
VL 193
BP 562
EP 573
DI 10.1016/j.ijbiomac.2021.10.165
EA OCT 2021
PN A
PG 12
WC Biochemistry & Molecular Biology; Chemistry, Applied; Polymer Science
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry; Polymer Science
GA XN5PE
UT WOS:000729556100010
PM 34715204
DA 2025-06-11
ER

PT J
AU Broussard, A
   Florwick, A
   Desbiens, C
   Nischan, N
   Robertson, C
   Guan, ZQ
   Kohler, JJ
   Wells, L
   Boyce, M
AF Broussard, Alex
   Florwick, Alyssa
   Desbiens, Chelsea
   Nischan, Nicole
   Robertson, Corrina
   Guan, Ziqiang
   Kohler, Jennifer J.
   Wells, Lance
   Boyce, Michael
TI Human UDP-galactose 4′-epimerase (GALE) is required for cell-surface
   glycome structure and function
SO JOURNAL OF BIOLOGICAL CHEMISTRY
LA English
DT Article
DE nucleoside; nucleotide metabolism; carbohydrate metabolism; galactose;
   glycobiology; glycoprotein; glycolipid; apoptosis; CD95 (APO-1/Fas);
   integrin; UDP-galactose 4 '-epimerase (GALE)
ID VERTEBRATE AMINO-SUGARS; O-LINKED GLYCOSYLATION; WHEAT-GERM-AGGLUTININ;
   ALPHA-5-BETA-1 INTEGRIN; N-ACETYLGALACTOSAMINE; GLCNAC TRANSFERASE;
   SERUM TRANSFERRIN; LELOIR PATHWAY; ER STRESS; EXPRESSION
AB Glycan biosynthesis relies on nucleotide sugars (NSs), abundant metabolites that serve as monosaccharide donors for glycosyltransferases. In vivo, signal-dependent fluctuations in NS levels are required to maintain normal cell physiology and are dysregulated in disease. However, how mammalian cells regulate NS levels and pathway flux remains largely uncharacterized. To address this knowledge gap, here we examined UDP-galactose 4'-epimerase (GALE), which interconverts two pairs of essential NSs. Using immunoblotting, flow cytometry, and LC-MS-based glycolipid and glycan profiling, we found that CRISPR/Cas9-mediated GALE deletion in human cells triggers major imbalances in NSs and dramatic changes in glycolipids and glycoproteins, including a subset of integrins and the cell-surface death receptor FS-7-associated surface antigen. In particular, we observed substantial decreases in total sialic acid, galactose, and GalNAc levels in glycans. These changes also directly impacted cell signaling, as GALE(-/-) cells exhibited FS-7-associated surface antigen ligand-induced apoptosis. Our results reveal a role of GALE-mediated NS regulation in death receptor signaling and may have implications for the molecular etiology of illnesses characterized by NS imbalances, including galactosemia and metabolic syndrome.
C1 [Broussard, Alex; Florwick, Alyssa; Robertson, Corrina; Guan, Ziqiang; Boyce, Michael] Duke Univ, Dept Biochem, Durham, NC 27710 USA.
   [Desbiens, Chelsea; Wells, Lance] Univ Georgia, Dept Chem, Athens, GA 30602 USA.
   [Wells, Lance] Univ Georgia, Dept Biochem & Mol Biol, Athens, GA 30602 USA.
   [Nischan, Nicole; Kohler, Jennifer J.] Univ Texas Southwestern Med Ctr Dallas, Dept Biochem, Dallas, TX 75390 USA.
   [Wells, Lance] Complex Carbohydrate Res Ctr, Thermo Fisher Ctr Excellence Glycoprote, Durham, NC USA.
C3 Duke University; University System of Georgia; University of Georgia;
   University System of Georgia; University of Georgia; University of Texas
   System; University of Texas Southwestern Medical Center Dallas
RP Boyce, M (corresponding author), Duke Univ, Dept Biochem, Durham, NC 27710 USA.
EM michael.boyce@duke.edu
RI Wells, Lance/H-3118-2013; Kohler, Jennifer/B-6589-2009
OI Kohler, Jennifer/0000-0001-5373-3329; Desbiens,
   Chelsea/0000-0003-2768-9306; Wells, Lance/0000-0003-4956-5363; Boyce,
   Michael/0000-0002-2729-4876
FU Rita Allen Foundation; NIGMS, National Institutes of Health [GM069338];
   NEI, National Institutes of Health [EY023666]; Welch Foundation
   [I-1686]; German Academic Exchange Service
FX This work was supported by a scholar award from the Rita Allen
   Foundation (to A. B. and M. B.); NIGMS, National Institutes of Health
   Grant GM069338 and NEI, National Institutes of Health Grant EY023666 (to
   Z. G.), Welch Foundation Grant I-1686 (to J. J. K.), and a postdoctoral
   fellowship from the German Academic Exchange Service (to N. N.). The
   authors declare that they have no conflicts of interest with the
   contents of this article. The content is solely the responsibility of
   the authors and does not necessarily represent the official views of the
   National Institutes of Health.
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NR 95
TC 22
Z9 23
U1 1
U2 27
PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
PI ROCKVILLE
PA 11200 ROCKVILLE PIKE, SUITE 302, ROCKVILLE, MD, UNITED STATES
SN 0021-9258
EI 1083-351X
J9 J BIOL CHEM
JI J. Biol. Chem.
PD JAN 31
PY 2020
VL 295
IS 5
BP 1225
EP 1239
DI 10.1074/jbc.RA119.009271
PG 15
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA KM0QP
UT WOS:000513822300006
PM 31819007
OA Green Published, hybrid, Green Submitted
DA 2025-06-11
ER

PT J
AU Bechynska, K
   Daskova, N
   Vrzackova, N
   Harant, K
   Heczková, M
   Podzimkova, K
   Bratova, M
   Dankova, H
   Berkova, Z
   Kosek, V
   Zelenka, J
   Hajslova, J
   Sedlacek, R
   Suttnar, J
   Hlavackova, A
   Bartonova, L
   Cahova, M
AF Bechynska, Kamila
   Daskova, Nikola
   Vrzackova, Nikola
   Harant, Karel
   Heczkova, Marie
   Podzimkova, Katerina
   Bratova, Miriam
   Dankova, Helena
   Berkova, Zuzana
   Kosek, Vit
   Zelenka, Jaroslav
   Hajslova, Jana
   Sedlacek, Radislav
   Suttnar, Jiri
   Hlavackova, Alzbeta
   Bartonova, Lenka
   Cahova, Monika
TI The effect of ω-3 polyunsaturated fatty acids on the liver lipidome,
   proteome and bile acid profile: parenteral versus enteral
   administration
SO SCIENTIFIC REPORTS
LA English
DT Article
ID CYTOCHROME-P450 ENZYMES; EICOSAPENTAENOIC ACID; METABOLIC SYNDROME;
   NUTRITION; MECHANISMS; EMULSION; ACTIVATION; PHYSIOLOGY; DISEASE;
   OMEGA-3-FATTY-ACIDS
AB Parenteral nutrition (PN) is often associated with the deterioration of liver functions (PNALD). Omega-3 polyunsaturated fatty acids (PUFA) were reported to alleviate PNALD but the underlying mechanisms have not been fully unraveled yet. Using omics' approach, we determined serum and liver lipidome, liver proteome, and liver bile acid profile as well as markers of inflammation and oxidative stress in rats administered either omega-6 PUFA based lipid emulsion (Intralipid) or omega-6/omega-3 PUFA blend (Intralipid/Omegaven) via the enteral or parenteral route. In general, we found that enteral administration of both lipid emulsions has less impact on the liver than the parenteral route. Compared with parenterally administered Intralipid, PN administration of omega-3 PUFA was associated with 1. increased content of eicosapentaenoic (EPA)- and docosahexaenoic (DHA) acids-containing lipid species; 2. higher abundance of CYP4A isoenzymes capable of bioactive lipid synthesis and the increased content of their potential products (oxidized EPA and DHA); 3. downregulation of enzymes involved CYP450 drug metabolism what may represent an adaptive mechanism counteracting the potential negative effects (enhanced ROS production) of PUFA metabolism; 4. normalized anti-oxidative capacity and 5. physiological BAs spectrum. All these findings may contribute to the explanation of omega-3 PUFA protective effects in the context of PN.
C1 [Bechynska, Kamila; Vrzackova, Nikola; Kosek, Vit; Zelenka, Jaroslav; Hajslova, Jana] Univ Chem & Technol, Prague, Czech Republic.
   [Daskova, Nikola; Heczkova, Marie; Bratova, Miriam; Dankova, Helena; Berkova, Zuzana; Cahova, Monika] Inst Clin & Expt Med, Ctr Expt Med, Prague, Czech Republic.
   [Harant, Karel] Charles Univ Prague, Fac Sci, BIOCEV, Prote Core Facil, Prague, Czech Republic.
   [Podzimkova, Katerina; Sedlacek, Radislav] Czech Ctr Phenogen, Vestec, Czech Republic.
   [Suttnar, Jiri; Hlavackova, Alzbeta] Inst Hematol & Blood Transfus, Prague, Czech Republic.
   [Bartonova, Lenka] Inst Clin & Expt Med, Dept Pathol, Prague, Czech Republic.
   [Bartonova, Lenka] Charles Univ Prague, Fac Med 1, Prague, Czech Republic.
C3 University of Chemistry & Technology, Prague; Institute for Clinical &
   Experimental Medicine (IKEM); Charles University Prague; Institute of
   Hematology Prague; Institute for Clinical & Experimental Medicine
   (IKEM); Charles University Prague
RP Cahova, M (corresponding author), Inst Clin & Expt Med, Ctr Expt Med, Prague, Czech Republic.
EM monika.cahova@ikem.cz
RI Kosek, Vít/AAD-3496-2021; Daskova, Nikola/AAX-6783-2021; Suttnar,
   Jiri/AAL-3889-2021; Cahova, Monika/Z-1568-2018; Berkova,
   Zuzana/D-9456-2018; Vrzáčková, Nikola/JVO-4604-2024; Hajslova,
   Jana/C-1279-2019; Sedlacek, Radislav/G-4408-2014; Bechynska,
   Kamila/AAA-7373-2021; Harant, Karel/L-2052-2014; Zelenka,
   Jaroslav/B-9660-2012
OI Hajslova, Jana/0000-0001-7443-4280; Suttnar, Jiri/0000-0003-4305-9718;
   Zelenka, Jaroslav/0000-0001-8145-8037; Berkova,
   Zuzana/0000-0001-8053-9978; Bechynska, Kamila/0000-0002-7962-4857;
   Daskova, Nikola/0000-0002-8038-8361; Kosek, Vit/0000-0003-2087-9596
FU Ministry of Health of the Czech Republic [15-28745 A AZV CR]; MH CZ-DRO
   (Institute for Clinical and Experimental Medicine-IKEM) [IN 00023001];
   European Regional Development Fund [AIIHHP:
   CZ.02.1.01/0.0/0.0/16_025/000 7428]; state budget of the Czech Republic
   [AIIHHP: CZ.02.1.01/0.0/0.0/16_025/000 7428]; Academy of Sciences of the
   Czech Republic [RVO 68378050]; Ministry of Education, Youth and Sports
   [LM2015040, CZ.1.05/2.1.00/19.0395, CZ.1.05/1.1.00/02.0109, Q1604]
FX This study was supported by the Ministry of Health of the Czech
   Republic, grant no. 15-28745 A AZV CR, by MH CZ-DRO (Institute for
   Clinical and Experimental Medicine-IKEM, IN 00023001), by the European
   Regional Development Fund and the state budget of the Czech Republic
   (project AIIHHP: CZ.02.1.01/0.0/0.0/16_025/000 7428, OP RDE, Ministry of
   Education, Youth and Sports), by RVO 68378050 by Academy of Sciences of
   the Czech Republic and by LM2015040, CZ.1.05/2.1.00/19.0395,
   CZ.1.05/1.1.00/02.0109, Q1604 funded by the Ministry of Education, Youth
   and Sports and the European Regional Development Fund.
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NR 58
TC 12
Z9 12
U1 3
U2 23
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD DEC 13
PY 2019
VL 9
AR 19097
DI 10.1038/s41598-019-54225-8
PG 14
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA JW5CO
UT WOS:000503069800001
PM 31836843
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Bao, LS
   Wang, JH
   Bin, SY
   Li, YL
   Chu, WY
   Zhang, JS
AF Bao, Lingsheng
   Wang, Jianhua
   Bin, Shiyu
   Li, Yulong
   Chu, Wuying
   Zhang, Jianshe
TI Effects of short-term fasting on the rhythmic expression of core
   circadian clock and functional genes in skeletal muscle of goldfish
   (Carassius auratus)
SO COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR
   BIOLOGY
LA English
DT Article
DE Circadian rhythm; Clock gene; Muscle functional gene; Fasting
ID MYOGENIC REGULATORY FACTORS; PERIPHERAL-TISSUES; DICENTRARCHUS-LABRAX;
   METABOLIC SYNDROME; GROWTH-FACTORS; INSULIN; LIVER; TRANSCRIPTOME;
   ENTRAINMENT; MECHANISMS
AB Molecular oscillators exist in peripheral tissues like pacemaker cells. Food intake is a dominant zeitgeber for peripheral clocks in vertebrates. Fasting is a physiological stress that elicits well-known metabolic adaptations, however, little is known about the effects of the rhythmic expression of clock components in skeletal muscle following short-term fasting in goldfish. Here, we characterized the molecular clock components and their daily transcription in COSINOR, and assessed the effect of 7-day fasting on the circadian patterns of the candidate genes expression in goldfish skeletal muscle. For the core clock genes, clock, bmal1a, cry1, cry2, cry3, per1, per2 and per3 showed circadian rhythmicity in fed goldfish, but not for bmal1a, cry2 and per1 in the fasted state. Of the 8 candidate functional genes analyzed, igf1, igf2 and igfbp2 showed circadian rhythmicity in the fed state, but circadian pattern was only observed for mRNA of myog, igfbp2 and mstn in fasted goldfish. Additionally, Spelman's correlation analysis showed the circadian expression of the myog and mstn presented positive and negative correlation with the transcription pattern of clock and per2 genes in fasted goldfish, respectively. Our results demonstrated that the peripheral clocks might be reset to respond rapidly to withholding of food in teleost skeletal muscle.
C1 [Bao, Lingsheng; Wang, Jianhua; Li, Yulong; Chu, Wuying; Zhang, Jianshe] Changsha Univ, Dept Biol & Environm Engn, Changsha 410003, Hunan, Peoples R China.
   [Wang, Jianhua; Bin, Shiyu] Guangxi Normal Univ, Coll Life Sci, Guilin 541004, Peoples R China.
C3 Changsha University; Guangxi Normal University
RP Chu, WY; Zhang, JS (corresponding author), Changsha Univ, Dept Biol & Environm Engn, Changsha 410003, Hunan, Peoples R China.
EM 2621372124@qq.com; jzhang@ccsu.edu.cn
FU National Natural Science Foundation of China [31472256, 31572592];
   Collaborative Innovation Center for efficient and Health Production of
   Fisheries in Hunan Province; Science and Technology Key Project of
   Changsha [ZD1601003]
FX This study was supported by the National Natural Science Foundation of
   China (No. 31472256 and No. 31572592), the Collaborative Innovation
   Center for efficient and Health Production of Fisheries in Hunan
   Province and the Science and Technology Key Project of Changsha
   (ZD1601003).
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NR 49
TC 3
Z9 4
U1 1
U2 30
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1096-4959
EI 1879-1107
J9 COMP BIOCHEM PHYS B
JI Comp. Biochem. Physiol. B-Biochem. Mol. Biol.
PD DEC
PY 2018
VL 226
BP 91
EP 98
DI 10.1016/j.cbpb.2018.07.006
PG 8
WC Biochemistry & Molecular Biology; Zoology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Zoology
GA GW6ZU
UT WOS:000447114400011
PM 30099196
DA 2025-06-11
ER

PT J
AU Wang, B
   Smyl, C
   Chen, CY
   Li, XY
   Huang, W
   Zhang, HM
   Pai, VJ
   Kang, JX
AF Wang, Bin
   Smyl, Christopher
   Chen, Chih-Yu
   Li, Xiang-Yong
   Huang, Wei
   Zhang, Hong-Man
   Pai, Victor J.
   Kang, Jing X.
TI Suppression of Postprandial Blood Glucose Fluctuations by a
   Low-Carbohydrate, High-Protein, and High-Omega-3 Diet via Inhibition of
   Gluconeogenesis
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE low-carbohydrate high-protein diet; omega-3 fatty acid; hyperglycemia;
   gluconeogenesis; glycemic control
ID TYPE-2 DIABETES-MELLITUS; OXIDATIVE STRESS; FATTY-ACIDS; DISEASE;
   HYPERGLYCEMIA; ALANINE; MORTALITY; OUTCOMES; THERAPY; EVENTS
AB Hyperglycemia significantly contributes to the development and progression of metabolic diseases. Managing postprandial blood glucose fluctuations is of particular importance for patients with hyperglycemia, but safe and effective means of reducing blood glucose levels are still lacking. Five diets with varying macronutrient ratios and omega-3 fatty acid amounts were tested for their blood glucose-lowering effects in male C57BL/6J mice. The diets with potent blood glucose-lowering effects were further investigated for their underlying mechanisms and their beneficial effects on hyperglycemia models. Mice given the low-carbohydrate, high-protein, and high-omega-3 (LCHP+3) diet exhibited a rapid reduction of the blood glucose levels that remained consistently low, regardless of feeding. These effects were associated with reduced amino acid gluconeogenesis, due to the inhibition of hepatic alanine transaminase (ALT). Furthermore, the LCHP+3 intervention was effective in reducing the blood glucose levels in several disease conditions, including type 1 diabetes mellitus, hormone-induced hyperglycemia, and diet-induced metabolic syndrome. Our findings identify the LCHP+3 diet as a potent blood glucose-lowering diet that suppresses postprandial blood glucose fluctuations through the inhibition of gluconeogenesis and may have great clinical utility for the management of metabolic diseases with hyperglycemia.
C1 [Wang, Bin; Smyl, Christopher; Chen, Chih-Yu; Li, Xiang-Yong; Huang, Wei; Zhang, Hong-Man; Pai, Victor J.; Kang, Jing X.] Massachusetts Gen Hosp, LLMT, Boston, MA 02129 USA.
   [Wang, Bin; Smyl, Christopher; Chen, Chih-Yu; Li, Xiang-Yong; Huang, Wei; Zhang, Hong-Man; Pai, Victor J.; Kang, Jing X.] Harvard Med Sch, Boston, MA 02129 USA.
   [Wang, Bin] Third Mil Med Univ, Inst Mil Prevent Med, Res Ctr Nutr & Food Safety, Chongqing 400038, Peoples R China.
   [Huang, Wei] Third Mil Med Univ, Biomed Anal Ctr, Chongqing 400038, Peoples R China.
C3 Harvard University; Harvard University Medical Affiliates; Massachusetts
   General Hospital; Harvard University; Harvard Medical School; Army
   Medical University; Army Medical University
RP Kang, JX (corresponding author), Massachusetts Gen Hosp, LLMT, Boston, MA 02129 USA.; Kang, JX (corresponding author), Harvard Med Sch, Boston, MA 02129 USA.
EM yy_bwang@hotmail.com; christopher.smyl@charite.de;
   cchen45@mgh.harvard.edu; xyli75@126.com; whuang_tmmu@hotmail.com;
   hmzhang9607@sina.com; victor.pai@phd.einstein.yu.edu;
   kang.jing@mgh.harvard.edu
RI Chen, Chih-Yu/Z-6008-2019
OI Pai, Victor/0000-0001-9710-7821; Wang, Bin/0000-0003-1963-409X
FU Sansun Life Sciences; Fortune Education Foundation; Natural Science
   Foundation of China [81472973]
FX This research was funded by Sansun Life Sciences and the Fortune
   Education Foundation and the Natural Science Foundation of China (Grant
   No. 81472973).
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NR 45
TC 13
Z9 15
U1 2
U2 18
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD JUL
PY 2018
VL 19
IS 7
AR 1823
DI 10.3390/ijms19071823
PG 13
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA GR6UX
UT WOS:000442807400002
PM 29933567
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Annette, B
   Ramesh, K
   Reddy, PH
AF Boles, Annette
   Kandimalla, Ramesh
   Reddy, P. Hemachandra
TI Dynamics of diabetes and obesity: Epidemiological perspective
SO BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
LA English
DT Review
DE Alzheimer's disease; Diabetes; Obesity; FTO
ID CARDIOVASCULAR RISK-FACTORS; STIFF-MAN SYNDROME; NUTRITION THERAPY
   RECOMMENDATIONS; GLYCOGEN-SYNTHASE KINASE-3; KLINEFELTERS-SYNDROME;
   INSULIN-RESISTANCE; SELF-MANAGEMENT; ANTIVIRAL ANTIBODIES;
   ALZHEIMERS-DISEASE; METABOLIC SYNDROME
AB The purpose of this review article is to understand the current literature on obesity, diabetes and therapeutic avenues across the world. Diabetes is a chronic lifestyle condition that affects millions of people worldwide and it is a major health concern in our society. Diabetes and obesity are associated with various conditions, including non modifiable and modifiable risk factors. Early detectable markers are not well established to detect pre-diabetes and as a result, it becomes diabetes. Several published epidemiological studies were assessed and the findings were summarized. Resources from published studies were used to identify criteria used for pre-diabetes, the role of diet in pre-diabetics and potential risks and characteristics associated with pre-diabetes. Preventive strategies are needed to combat diabetes. Individuals diagnosed with pre-diabetes need detailed education, need to fully understand the risk factors and have the ability to manage diabetes. Interventions exist that include chronic disease self-management programs, lifestyle interventions and pharmacological strategies. Obesity plays a large role in causing pre-diabetes and diabetes. Critical analysis of existing epidemiological research data suggests that additional research is needed to determine the efficacy of interventions. This article is part of a Special Issue entitled: Oxidative Stress and Mitochondrial Quality in Diabetes/Obesity and Critical Illness Spectrum of Diseases edited by P. Hemachandra Reddy. (C) 2017 Elsevier B.V. All rights reserved.
C1 [Boles, Annette; Reddy, P. Hemachandra] Community Outreach & Educ, 6630 S Quaker Ave,Suite E, Lubbock, TX 79413 USA.
   [Kandimalla, Ramesh; Reddy, P. Hemachandra] Texas Tech Univ, Hlth Sci Ctr, Garrison Inst Aging, 3601 4th St,MS 9424, Lubbock, TX 79430 USA.
   [Reddy, P. Hemachandra] Texas Tech Univ, Hlth Sci Ctr, Dept Cell Biol & Biochem, 3601 4th St, Lubbock, TX 79430 USA.
   [Reddy, P. Hemachandra] Texas Tech Univ, Hlth Sci Ctr, Dept Pharmacol & Neurosci, 3601 4th St, Lubbock, TX 79430 USA.
   [Reddy, P. Hemachandra] Texas Tech Univ, Hlth Sci Ctr, Dept Neurol, 3601 4th St, Lubbock, TX 79430 USA.
   [Reddy, P. Hemachandra] Texas Tech Univ, Hlth Sci Ctr, Speech Dept, 3601 4th St, Lubbock, TX 79430 USA.
   [Reddy, P. Hemachandra] Texas Tech Univ, Hlth Sci Ctr, Language & Hearing Sci Dept, 3601 4th St, Lubbock, TX 79430 USA.
   [Reddy, P. Hemachandra] Dept Publ Hlth, 3601 4th St,MS 9424, Lubbock, TX 79430 USA.
C3 Texas Tech University System; Texas Tech University Health Sciences
   Center Lubbock; Texas Tech University System; Texas Tech University
   Health Sciences Center Lubbock; Texas Tech University System; Texas Tech
   University Health Sciences Center Lubbock; Texas Tech University System;
   Texas Tech University Health Sciences Center Lubbock; Texas Tech
   University System; Texas Tech University Health Sciences Center Lubbock;
   Texas Tech University System; Texas Tech University Health Sciences
   Center Lubbock; Texas Tech University System; Texas Tech University
   Health Sciences Center Lubbock
RP Ramesh, K (corresponding author), Texas Tech Univ, Hlth Sci Ctr, Garrison Inst Aging, 3601 4th St,MS 9424, Lubbock, TX 79430 USA.; Annette, B (corresponding author), Texas Tech Univ, Hlth Sci Ctr, Garrison Inst Aging, 6630 S Quaker Ste E,MS 7495, Lubbock, TX 79413 USA.
EM annette.boles@ttuhsc.edu; ramesh.kandimalla@ttuhsc.edu
RI Kandimalla, Ramesh/O-4047-2017
OI Kandimalla, Ramesh/0000-0002-3313-4393
FU NIH grants [AG042178, AG047812]; Garrison Family Foundation
FX NIH grants (AG042178, AG047812) & the Garrison Family Foundation support
   this work.
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NR 126
TC 175
Z9 188
U1 1
U2 34
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0925-4439
EI 1879-260X
J9 BBA-MOL BASIS DIS
JI Biochim. Biophys. Acta-Mol. Basis Dis.
PD MAY
PY 2017
VL 1863
IS 5
SI SI
BP 1026
EP 1036
DI 10.1016/j.bbadis.2017.01.016
PG 11
WC Biochemistry & Molecular Biology; Biophysics; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Cell Biology
GA EU5BO
UT WOS:000401046800002
PM 28130199
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Li, M
   Shu, XB
   Xu, HC
   Zhang, CL
   Yang, LL
   Zhang, L
   Ji, G
AF Li, Meng
   Shu, Xiangbing
   Xu, Hanchen
   Zhang, Chunlei
   Yang, Lili
   Zhang, Li
   Ji, Guang
TI Integrative analysis of metabolome and gut microbiota in diet-induced
   hyperlipidemic rats treated with berberine compounds
SO JOURNAL OF TRANSLATIONAL MEDICINE
LA English
DT Article
DE Berberine compounds; Integrative metabolomics; Gut microbiota;
   Hyperlipidemia
ID COLON-CANCER; OXIDATIVE STRESS; RISK-FACTOR; ACID; DYSLIPIDEMIA;
   GLUTAMINE; PROFILES; EXTRACT; ENERGY; SERUM
AB Background: Hyperlipidemia is a major component of metabolic syndrome, and often predicts cardiovascular diseases. We developed a new therapeutic agent berberine compounds (BC), consisting of berberine, oryzanol and vitamin B6, and determined their anti-hyperlipidemia activity and underlying mechanisms.
   Methods: Male Wistar rats were fed a high fat diet (HFD) to induce hyperlipidemia, and then given BC orally for 4 weeks. Body weight and food intake were recorded weekly, and lipid profiles in serum were determined biochemically. Metabolites in serum, urine, liver and feces were analyzed by GC-MS, and the structure of microbiota was determined by 16S rDNA sequencing.
   Results: Lipid lowering was observed in the hyperlipidemic rats upon BC treatment without apparent adverse side effects. Metabolomics analysis indicated that the BC treatment resulted in increased pyruvic acid, serotonin, and ketogenic and glycogenic amino acid levels in the serum, increased pyridoxine and 4-pyridoxic acid in the urine, decreased hypotaurine and methionine in the liver, and increased putrescine and decreased deoxycholate and lithocholate in feces. The BC treatment also resulted in an enrichment of beneficial bacteria (e.g. Bacteroides, Blautia) and a decrease in Escherichia.
   Conclusions: The lipid lowering effect of BC treatment in hyperlipidemic rats is associated with a global change in the metabolism of lipids, carbohydrates and amino acids, as well as the structure of microbiota.
C1 [Li, Meng; Shu, Xiangbing; Xu, Hanchen; Zhang, Chunlei; Yang, Lili; Zhang, Li; Ji, Guang] Shanghai Univ Tradit Chinese Med, Longhua Hosp, Inst Digest Dis, ccCRDD, Shanghai 200032, Peoples R China.
   [Ji, Guang] Shanghai Univ Tradit Chinese Med, E Inst Shanghai Municipal Educ Commiss, Shanghai 201203, Peoples R China.
C3 Shanghai University of Traditional Chinese Medicine; Shanghai University
   of Traditional Chinese Medicine
RP Ji, G (corresponding author), Shanghai Univ Tradit Chinese Med, Longhua Hosp, Inst Digest Dis, ccCRDD, Shanghai 200032, Peoples R China.; Ji, G (corresponding author), Shanghai Univ Tradit Chinese Med, E Inst Shanghai Municipal Educ Commiss, Shanghai 201203, Peoples R China.
EM jiliver@vip.sina.com
OI Li, Meng/0000-0002-3602-3429
FU National Nature Science Foundation of China [81273727, 81302927];
   Innovation Program of Shanghai Municipal Education Commission [14YZ054]
FX This study was supported by the National Nature Science Foundation of
   China (Nos. 81273727, 81302927), Innovation Program of Shanghai
   Municipal Education Commission, No. 14YZ054.
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NR 48
TC 98
Z9 115
U1 3
U2 80
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1479-5876
J9 J TRANSL MED
JI J. Transl. Med.
PD AUG 5
PY 2016
VL 14
AR 237
DI 10.1186/s12967-016-0987-5
PG 13
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA DU5ZM
UT WOS:000382292200003
PM 27495782
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Hardy, CM
   Birse, RT
   Wolf, MJ
   Yu, L
   Bodmer, R
   Gibbs, AG
AF Hardy, Christopher M.
   Birse, Ryan T.
   Wolf, Matthew J.
   Yu, Lin
   Bodmer, Rolf
   Gibbs, Allen G.
TI Obesity-associated cardiac dysfunction in starvation-selected
   Drosophila melanogaster
SO AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE
   PHYSIOLOGY
LA English
DT Article
DE obesity; heart disease; Drosophila melanogaster; starvation selection;
   laboratory natural selection
ID DIABETES-MELLITUS; RESISTANCE; HOMEOSTASIS; METABOLISM; MECHANISMS;
   MODEL; LIPOTOXICITY; TOR
AB There is a clear link between obesity and cardiovascular disease, but the complexity of this interaction in mammals makes it difficult to study. Among the animal models used to investigate obesity-associated diseases, Drosophila melanogaster has emerged as an important platform of discovery. In the laboratory, Drosophila can be made obese through lipogenic diets, genetic manipulations, and adaptation to evolutionary stress. While dietary and genetic changes that cause obesity in flies have been demonstrated to induce heart dysfunction, there have been no reports investigating how obesity affects the heart in laboratory-evolved populations. Here, we studied replicated populations of Drosophila that had been selected for starvation resistance for over 65 generations. These populations evolved characteristics that closely resemble hallmarks of metabolic syndrome in mammals. We demonstrate that starvation-selected Drosophila have dilated hearts with impaired contractility. This phenotype appears to be correlated with large fat deposits along the dorsal cuticle, which alter the anatomical position of the heart. We demonstrate a strong relationship between fat storage and heart dysfunction, as dilation and reduced contractility can be rescued through prolonged fasting. Unlike other Drosophila obesity models, the starvation-selected lines do not exhibit excessive intracellular lipid deposition within the myocardium and rather store excess triglycerides in large lipid droplets within the fat body. Our findings provide a new model to investigate obesity-associated heart dysfunction.
C1 [Hardy, Christopher M.; Gibbs, Allen G.] Univ Nevada, Sch Life Sci, Las Vegas, NV 89154 USA.
   [Birse, Ryan T.; Bodmer, Rolf] Sanford Burnham Med Res Inst, Dev Aging & Regenerat Program, La Jolla, CA USA.
   [Wolf, Matthew J.] Univ Virginia, Sch Med, Dept Med, Robert M Berne Cardiovasc Res Ctr, Charlottesville, VA 22908 USA.
   [Yu, Lin] Duke Univ, Sch Med Cardiol, Durham, NC USA.
C3 Nevada System of Higher Education (NSHE); University of Nevada Las
   Vegas; Sanford Burnham Prebys Medical Discovery Institute; University of
   Virginia; Duke University
RP Hardy, CM (corresponding author), Sch Life Sci, Las Vegas, NV 89154 USA.
EM christopher.hardy@unlv.edu
RI Hardy, Christopher/KLC-1943-2024; Gibbs, Allen/G-6939-2014; WOLF,
   MATTHEW/AHC-5201-2022
OI Hardy, Christopher/0000-0003-0364-9756; Wolf,
   Matthew/0000-0001-8004-4852
FU National Institutes of Health [R15-GM-100395, R01-HL-54732-19,
   5-P01-AG-033561-05, 5-P01-HL-098053-05, P20-GM-103440]; National Science
   Foundation [IOS-1355210]; American Heart Association [AHA 12
   SDG12200029]
FX C. M. Hardy and A. G. Gibbs were supported by the National Institutes of
   Health (R15-GM-100395) and the National Science Foundation
   (IOS-1355210). R. T. Birse was supported by the American Heart
   Association (AHA 12 SDG12200029). R. Bodmer was supported by the
   National Institutes of Health (R01-HL-54732-19; 5-P01-AG-033561-05, and
   5-P01-HL-098053-05). Work in the University of Nevada Las Vegas Genomics
   Core facility was supported by the National Institutes of Health
   (P20-GM-103440).
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NR 52
TC 21
Z9 30
U1 0
U2 20
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0363-6119
EI 1522-1490
J9 AM J PHYSIOL-REG I
JI Am. J. Physiol.-Regul. Integr. Comp. Physiol.
PD SEP 15
PY 2015
VL 309
IS 6
BP R658
EP R667
DI 10.1152/ajpregu.00160.2015
PG 10
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA CS1KB
UT WOS:000361821800004
PM 26136533
OA Green Published
DA 2025-06-11
ER

PT J
AU Cardoso, LM
   Novaes, RD
   De Castro, CA
   Novello, AA
   Gonçalves, RV
   Ricci-Silva, ME
   Ramos, HJD
   Peluzio, MDG
   Leite, JPV
AF Cardoso, Luciana Marques
   Novaes, Romulo Dias
   De Castro, Cynthia Aparecida
   Novello, Alexandre Azevedo
   Goncalves, Reggiani Vilela
   Ricci-Silva, Maria Esther
   de Oliveira Ramos, Humberto Josue
   Gouveia Peluzio, Maria do Carmo
   Viana Leite, Joao Paulo
TI Chemical composition, characterization of anthocyanins and antioxidant
   potential of Euterpe edulis fruits: applicability on genetic
   dyslipidemia and hepatic steatosis in mice
SO NUTRICION HOSPITALARIA
LA English
DT Article
DE Anthocyanins; Arecaceae; Euterpe edulis; Functional food; Liver disease
ID E-DEFICIENT MICE; CARDIOVASCULAR-DISEASE; DENSITY-LIPOPROTEIN; METABOLIC
   SYNDROME; OXIDATIVE STRESS; OLERACEA MART.; RICH EXTRACT; ACAI; DIET;
   RATS
AB The significance of polyphenol intake for the prevention of chronic diseases is controversial.
   Objective: this study investigated the chemical composition and antioxidant potential of an anthocyanin-rich extract from Euterpe edulis fruits (LPEF) and its effects on liver steatosis in dyslipidemic apoE knockout mice.
   Materials and methods: mice were divided into G1 (C57BL/6) standard diet; G2 (apoE(-/-)) standard diet, G3 (apoE(-/-)) 2% LPEF, G4 (apoE(-/-)) 6% LPEF, G5 (apoE(-/-)) 10% LPEF, G6 (apoE(-/-)) 2% a-tocopherol acetate. After 75 days of treatment, the animals were euthanized. The LPEF contained a high level of monomeric anthocyanins (301.4 mg/100g) and marked antioxidant activity.
   Results: Catalase activity was reduced in G3, G4, G5 and G6 compared to G2. Superoxide dismutase was reduced only in G4. The animals in G4, G5, and G6 showed low HDL and triglycerides levels compared to G2. The proportion of lipid droplets in liver tissue was reduced in G4 and G5 compared to G2, G3, and G6.
   Conclusion: The results indicated that E. edulis pulp is rich in anthocyanins and the LPEF dietary consumption can reduce the severity of liver steatosis in apoE(-/-) mice, an effect that is potentially mediated by the antioxidant activity of this extract and modulation of triglyceride serum levels.
C1 [Cardoso, Luciana Marques; de Oliveira Ramos, Humberto Josue; Viana Leite, Joao Paulo] Univ Fed Vicosa, Dept Biochem & Mol Biol, BR-35570000 Vicosa, MG, Brazil.
   [Novaes, Romulo Dias] Univ Fed Alfenas, Dept Cell Tissue & Dev Biol, Alfenas, MG, Brazil.
   [De Castro, Cynthia Aparecida; Novello, Alexandre Azevedo; Gouveia Peluzio, Maria do Carmo] Univ Fed Vicosa, Dept Nutr & Hlth, BR-35570000 Vicosa, MG, Brazil.
   [Goncalves, Reggiani Vilela] Univ Fed Vicosa, Dept Anim Biol, BR-35570000 Vicosa, MG, Brazil.
   [Ricci-Silva, Maria Esther] Univ Fed Vicosa, Dept Biol Vegetal, BR-35570000 Vicosa, MG, Brazil.
C3 Universidade Federal de Vicosa; Universidade Federal de Alfenas;
   Universidade Federal de Vicosa; Universidade Federal de Vicosa;
   Universidade Federal de Vicosa
RP Leite, JPV (corresponding author), Univ Fed Vicosa, Dept Biochem & Mol Biol, Ave PH Rolfs S-N, BR-35570000 Vicosa, MG, Brazil.
EM jpvleite@ufv.br
RI Ramos, Humberto/ACL-0827-2022; Gonçalves, Reggiani/J-1550-2016; Castro,
   Cynthia/GQP-6823-2022; Dias Novaes, Romulo/F-1210-2015
OI PELUZIO, MARIA DO CARMO GOUVEIA/0000-0003-4665-7043; Leite,
   Joao/0000-0002-3747-4424; Dias Novaes, Romulo/0000-0002-3186-5328
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NR 35
TC 30
Z9 31
U1 0
U2 34
PU AULA MEDICA EDICIONES
PI MADRID
PA C/ISABEL COLBRAND, 10-12 NAVE 78 S PLANTA CIUDAD INDUSTRIAL
   VENECIA-EDIFICIO ALFA, MADRID, 28050, SPAIN
SN 0212-1611
J9 NUTR HOSP
JI Nutr. Hosp.
PD AUG
PY 2015
VL 32
IS 2
BP 702
EP 709
DI 10.3305/nh.2015.32.2.8885
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA CO3BH
UT WOS:000359031000030
PM 26268102
DA 2025-06-11
ER

PT J
AU Shi, LY
   Zhang, T
   Liang, XY
   Hu, Q
   Huang, J
   Zhou, Y
   Chen, ML
   Zhang, QY
   Zhu, JD
   Mi, MT
AF Shi, Linying
   Zhang, Ting
   Liang, Xinyu
   Hu, Qin
   Huang, Juan
   Zhou, Yong
   Chen, Mingliang
   Zhang, Qianyong
   Zhu, Jundong
   Mi, Mantian
TI Dihydromyricetin improves skeletal muscle insulin resistance by inducing
   autophagy via the AMPK signaling pathway
SO MOLECULAR AND CELLULAR ENDOCRINOLOGY
LA English
DT Article
DE AMPK; Autophagy; Dihydromyricetin; Skeletal muscle insulin resistance;
   Type 2 diabetes
ID ACTIVATED PROTEIN-KINASE; ENDOPLASMIC-RETICULUM STRESS; REGULATES
   INFLAMMATION; METABOLIC SYNDROME; CELLS; OBESITY; THERAPEUTICS;
   HOMEOSTASIS; MECHANISMS; NUTRIENT
AB Skeletal muscle insulin resistance (SMIR) plays an important role in the pathogenesis of type 2 diabetes. Dihydromyricetin (OHM), a natural flavonoid, exerts various bioactivities including anti-oxidative and hepatoprotective effects. Herein, we intended to determine the effect of DHM on SMIR and the underlying mechanisms. We found that DHM increased the expression of phosphorylated insulin receptor substrate-1, phosphorylated Akt and glucose uptake capacity in palmitate-treated L6 myotubes under insulin-stimulated conditions. The expression of light chain 3, Beclin 1, autophagy-related gene 5 (Atg5), the degradation of sequestosome 1 and the formation of autophagosomes were also upregulated by OHM. Suppression of autophagy by 3-methyladenine and bafilomycin Al or Atg5 and Beclin1 siRNA abolished the favorable effects of DHM on SMIR. Furthermore, DHM increased the levels of phosphorylated AMP-activated protein kinase (AMPK) and Ulk1, and decreased phosphorylated mTOR levels. AMPK inhibitor compound C (CC) and AMPK siRNA abrogated DHM-induced autophagy, subsequently suppressed OHM-induced SMIR improvement. Additionally, DHM inhibited the activity of F1F0-ATPase thereby activating AMPK. Finally, the results of in vivo study conducted in high fat diet-fed rats were consistent with the findings of in vitro study. In conclusion, DHM improved SMIR by inducing autophagy via the activation of AMPK signaling pathway. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
C1 [Shi, Linying; Zhang, Ting; Liang, Xinyu; Hu, Qin; Huang, Juan; Zhou, Yong; Chen, Mingliang; Zhang, Qianyong; Zhu, Jundong; Mi, Mantian] Third Mil Med Univ, Chongqing Key Lab Nutr & Food Safety, Inst Mil Prevent Med, Res Ctr Nutr & Food Safety, Chongqing 400038, Peoples R China.
C3 Army Medical University
RP Zhu, JD (corresponding author), Third Mil Med Univ, Chongqing Key Lab Nutr & Food Safety, Inst Mil Prevent Med, Res Ctr Nutr & Food Safety, 30th Gaotanyan Main St, Chongqing 400038, Peoples R China.
EM zjdnfs@126.com; mi_mt2009@hotmail.com
RI Chen, Mingliang/AGH-3195-2022; Zhang, Tingting/HZM-2762-2023
FU National Natural Science Foundation of China [81372975]; special fund of
   Chongqing Key Laboratory (CSTC) for Nutrition and Food Safety
   [CSTC201ljjA1532]
FX This work was supported by the research grant from National Natural
   Science Foundation of China (81372975) and the special fund of Chongqing
   Key Laboratory (CSTC201ljjA1532) (CSTC) for Nutrition and Food Safety.
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NR 43
TC 73
Z9 88
U1 0
U2 75
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0303-7207
J9 MOL CELL ENDOCRINOL
JI Mol. Cell. Endocrinol.
PD JUL 5
PY 2015
VL 409
IS C
BP 92
EP 102
DI 10.1016/j.mce.2015.03.009
PG 11
WC Cell Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Endocrinology & Metabolism
GA CI8QH
UT WOS:000355036300010
PM 25797177
DA 2025-06-11
ER

PT J
AU Pickens, CA
   Sordillo, LM
   Comstock, SS
   Harris, WS
   Hortos, K
   Kovan, B
   Fenton, JI
AF Pickens, C. Austin
   Sordillo, Lorraine M.
   Comstock, Sarah S.
   Harris, William S.
   Hortos, Kari
   Kovan, Bruce
   Fenton, Jenifer I.
TI Plasma phospholipids, non-esterified plasma polyunsaturated fatty acids
   and oxylipids are associated with BMI
SO PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
LA English
DT Article
DE Lipidome; Obesity; Human; Biomarker; Inflammation; Nervonic acid
ID ALPHA-LINOLENIC ACID; METABOLIC SYNDROME; INSULIN-RESISTANCE;
   ARACHIDONIC-ACID; PPAR-GAMMA; ADIPOSE-TISSUE; OBESE SUBJECTS; LIPOXIN
   A(4); SERUM-LIPIDS; DISEASE
AB The obese lipid profile is associated with increased free fatty acids and triacylglycerides. Currently, little is known about the plasma lipid species associated with obesity. In this study, we compared plasma lipid fatty acid (FA) profiles as a function of BMI. Profiling phospholipid (PL) FAs and their respective oxylipids could predict which obese individuals are more likely to suffer from diseases associated with chronic inflammation or oxidative stress. We investigated the relationship between BMI and plasma PL (PPL) FA composition in 126 men using a quantitative gas chromatography analysis. BMI was inversely associated with both PPL nervonic and linoleic acid (LA) but was positively associated with both dihomo-gamma-linolenic and palmitoleic acid. Compared to lean individuals, obese participants were more likely to have omega-6 FAs, except arachidonic acid and LA, incorporated into PPLs. Obese participants were less likely to have EPA and DHA incorporated into PPLs compared to lean participants. Non-esterified plasma PUFA and oxylipid analysis showed omega-6 oxylipids were more abundant in the obese plasma pool. These omega-6 oxylipids are associated with increased angiogenesis (i.e. epoxyeicosatrienoates), reactive oxygen species (i.e. 9-hydroxyeicosatetraenoate), and inflammation resolution (i.e. Lipoxin A4). In summary, BMI is directly associated with specific PPL FA and increased omega-6 oxylipids. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Pickens, C. Austin; Comstock, Sarah S.; Fenton, Jenifer I.] Michigan State Univ, Dept Food Sci & Human Nutr, E Lansing, MI 48824 USA.
   [Sordillo, Lorraine M.] Michigan State Univ, Coll Vet Med, E Lansing, MI 48824 USA.
   [Harris, William S.] Univ S Dakota, Sanford Sch Med, Sioux Falls, SD USA.
   [Hortos, Kari; Kovan, Bruce] Michigan State Univ, Coll Osteopath Med, E Lansing, MI 48824 USA.
   [Kovan, Bruce] Clinton Tri Cty Gastroenterol Profess Corp, Tri Cty Gastroenterol Profess Corp, Clinton Township, MI USA.
C3 Michigan State University; Michigan State University; University of
   South Dakota; Michigan State University; Michigan State University
   College of Osteopathic Medicine
RP Fenton, JI (corresponding author), Michigan State Univ, 469 Wilson Rd,Rm 208B, E Lansing, MI 48824 USA.
EM imigjeni@msu.edu
RI Harris, William/T-1674-2019
OI Sordillo, Lorraine/0000-0001-8873-3134; Pickens,
   Austin/0000-0003-1632-5777; Fenton, Jenifer/0000-0002-8875-3239
FU National Cancer Institute [1R03CA142000]; Clinical and Translational
   Sciences Institute at MSU
FX We would like to thank Wenjuan Ma from MSU Center for Statistical
   Training and Consulting for statistical help and input, MSU Mass
   Spectrometry and Metabolomics Core Facility, Daniel Jones for
   metabolomic consultation and project design, and Ami Lane-Elliot and
   Catherine Belcher for helping with sample processing. Research supported
   in part by the National Cancer Institute 1R03CA142000 and the Clinical
   and Translational Sciences Institute at MSU.
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NR 62
TC 59
Z9 62
U1 2
U2 30
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0952-3278
EI 1532-2823
J9 PROSTAG LEUKOTR ESS
JI Prostaglandins Leukot. Essent. Fatty Acids
PD APR
PY 2015
VL 95
BP 31
EP 40
DI 10.1016/j.plefa.2014.12.001
PG 10
WC Biochemistry & Molecular Biology; Cell Biology; Endocrinology &
   Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology; Endocrinology &
   Metabolism
GA CE4NE
UT WOS:000351806500004
PM 25559239
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Shen, H
   Shahzad, G
   Jawairia, M
   Bostick, RM
   Mustacchia, P
AF Shen, H.
   Shahzad, G.
   Jawairia, M.
   Bostick, R. M.
   Mustacchia, P.
TI Association between aspirin use and the prevalence of nonalcoholic fatty
   liver disease: a cross-sectional study from the Third National Health
   and Nutrition Examination Survey
SO ALIMENTARY PHARMACOLOGY & THERAPEUTICS
LA English
DT Article
ID INSULIN-RESISTANCE; METABOLIC SYNDROME; OXIDATIVE STRESS; NITRIC-OXIDE;
   DOSE ASPIRIN; STEATOHEPATITIS; PERMEABILITY; INFLAMMATION; POPULATION;
   ACTIVATION
AB BackgroundMany basic mechanistic studies found that aspirin inhibited multiple pathways involved in non-alcoholic fatty liver disease (NAFLD) development.
   AimTo investigate an association between aspirin use and NAFLD prevalence in the general US population.
   MethodsWe conducted a cross-sectional analysis of data from the Third National Health and Nutrition Examination Survey (NHANES III). We included 11416 adults aged 20-74years who underwent ultrasonography; of those, 2889 were identified as having NAFLD and 8527 as controls. Aspirin use during the month prior to interview was categorised as never use (0 times), occasional use (1-14 times) and regular use (15 times).
   ResultsIn the multivariate unconditional logistic regression analysis, regular relative to no aspirin use was inversely associated with prevalent NAFLD [odds ratio (OR)=0.62, 95% confidence interval (CI) 0.51-0.74; P for trend=0.04], a finding that was primarily limited to men (OR=0.32, 95% CI 0.23-0.45; P for interaction<0.01) and those who were older (>60years) (OR=0.21, 95% CI 0.14-0.30; P for interaction<0.01).
   ConclusionThese findings, from the first human study to investigate an association of aspirin use with NAFLD, suggest that regular aspirin use (15times per month) may be associated with a lower prevalence of NAFLD, primarily among men and older patients.
C1 [Shen, H.] Nassau Univ Med Ctr, Dept Med, E Meadow, NY 11554 USA.
   [Shahzad, G.; Jawairia, M.; Mustacchia, P.] Nassau Univ Med Ctr, Dept Med, Div Gastroenterol, E Meadow, NY 11554 USA.
   [Bostick, R. M.] Emory Univ, Dept Epidemiol, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA.
C3 Emory University; Rollins School Public Health
RP Shen, H (corresponding author), Nassau Univ Med Ctr, Dept Med, 2201 Hempstead Turnpike, E Meadow, NY 11554 USA.
EM hshen@numc.edu
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NR 32
TC 53
Z9 52
U1 1
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0269-2813
EI 1365-2036
J9 ALIMENT PHARM THER
JI Aliment. Pharmacol. Ther.
PD NOV
PY 2014
VL 40
IS 9
BP 1066
EP 1073
DI 10.1111/apt.12944
PG 8
WC Gastroenterology & Hepatology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Pharmacology & Pharmacy
GA AQ6EU
UT WOS:000342903400007
PM 25176122
DA 2025-06-11
ER

PT J
AU Pires, KM
   Ilkun, O
   Valente, M
   Boudina, S
AF Pires, Karla M.
   Ilkun, Olesya
   Valente, Marina
   Boudina, Sihem
TI Treatment with a SOD mimetic reduces visceral adiposity, adipocyte
   death, and adipose tissue inflammation in high fat-fed mice
SO OBESITY
LA English
DT Article
ID DIET-INDUCED OBESITY; INDUCED INSULIN-RESISTANCE; SYSTEMIC OXIDATIVE
   STRESS; SKELETAL-MUSCLE; METABOLIC SYNDROME; DOWN-REGULATION; IN-VITRO;
   SUPEROXIDE; CONTRIBUTES; RATS
AB Objective Obesity is associated with enhanced reactive oxygen species (ROS) accumulation in adipose tissue. However, a causal role for ROS in adipose tissue expansion after high fat feeding is not established. The aim of this study is to investigate the effect of the cell permeable superoxide dismutase mimetic and peroxynitrite scavenger Mn(III)tetrakis(4-benzoic acid)porphyrin chloride (MnTBAP) on adipose tissue expansion and remodeling in response to high fat diet (HFD) in mice. Design and Methods Male C57BL/6j mice were fed normal chow or high fat diet (HFD) and treated with saline or MnTBAP for 5 weeks. The effects of MnTBAP on body weights, whole body energy expenditure, adipose tissue morphology, and gene expression were determined. Results MnTBAP attenuated weight gain and adiposity through a reduction in adipocyte hypertrophy, adipogenesis, and fatty acid uptake in epididymal (eWAT) but not in inguinal (iWAT) white adipose tissue. Furthermore, MnTBAP reduced adipocyte death and inflammation in eWAT and diminished circulating levels of free fatty acids and leptin. Despite these improvements, the development of systemic insulin resistance and diabetes after HFD was not prevented with MnTBAP treatment. Conclusions Taken together, these data suggest a causal role for ROS in the development of diet-induced visceral adiposity but not in the development of insulin resistance and type 2 diabetes.
C1 [Boudina, Sihem] Univ Utah, Sch Med, Div Endocrinol Metab & Diabet, Salt Lake City, UT 84112 USA.
   Univ Utah, Sch Med, Program Mol Med, Salt Lake City, UT USA.
C3 Utah System of Higher Education; University of Utah; Utah System of
   Higher Education; University of Utah
RP Boudina, S (corresponding author), Univ Utah, Sch Med, Div Endocrinol Metab & Diabet, Salt Lake City, UT 84112 USA.
EM sihem.boudina@hmbg.utah.edu
OI Valente Barroso, Marina/0000-0001-8135-9100
FU American Heart Association [09SDG2220218]; National Institutes of Health
   (NIH) [P30-HL-101310]; Assessoria de Cooperacao Internacional
   Coordenacao de Cooperacao Bilateral Programa CSF-Programa Ciencia sem
   Fronteiras (COCBI); NIH/NIDDK [T32DK091317]; Brazilian Scientific
   Mobility Programs; American Heart Association (AHA) [09SDG2220218]
   Funding Source: American Heart Association (AHA)
FX This research was supported by a Scientist Development Grant
   09SDG2220218 from the American Heart Association and a P30-HL-101310
   from the National Institutes of Health (NIH) to Sihem Boudina. Karla M.
   Pires is supported by a post-doctoral training grant from "Assessoria de
   Cooperacao Internacional Coordenacao de Cooperacao Bilateral Programa
   CSF-Programa Ciencia sem Fronteiras (COCBI)". Olesya Ilkun is supported
   by T32DK091317 training grant from NIH/NIDDK. Marina Valente is
   supported by the Science without Border Undergraduate Fellowship from
   the Brazilian Scientific Mobility Programs.
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NR 38
TC 23
Z9 25
U1 0
U2 14
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1930-7381
EI 1930-739X
J9 OBESITY
JI Obesity
PD JAN
PY 2014
VL 22
IS 1
BP 178
EP 187
DI 10.1002/oby.20465
PG 10
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 288LN
UT WOS:000329613600027
PM 23526686
OA Bronze, Green Accepted
DA 2025-06-11
ER

PT J
AU Shih, PH
   Chan, YC
   Liao, JW
   Wang, MF
   Yen, GC
AF Shih, Ping-Hsiao
   Chan, Yin-Ching
   Liao, Jiunn-Wang
   Wang, Ming-Fu
   Yen, Gow-Chin
TI Antioxidant and cognitive promotion effects of anthocyanin-rich mulberry
   (Morus atropurpurea L.) on senescence-accelerated mice and
   prevention of Alzheimer's disease
SO JOURNAL OF NUTRITIONAL BIOCHEMISTRY
LA English
DT Article
DE SAMP8; Amyloid; Anthocyanin; Mulberry; Nrf2; MAPK
ID OXIDATIVE STRESS; METABOLIC SYNDROME; GENE-EXPRESSION; AGE; PROTEIN;
   BRAIN; MODEL; RATS; FLAVONOIDS; PATHWAYS
AB In the present study, we evaluated the beneficial effect of mulberry extracts (ME), which are rich in phenolics and anthocyanins, on the induction of antioxidant enzymes and on the promotion of cognition in senescence-accelerated mice (SAMP). Six-month old SAMP8 and SAMR1 mice were fed a basal diet supplemented with 0.18% and 0.9% ME for consecutive 12 weeks. The results showed that the mice fed the ME supplement demonstrated significantly less amyloid p, protein and showed improved learning and memory ability in avoidance response tests. ME-treated mice showed a higher antioxidant enzyme activity and less lipid oxidation in both the brain and liver, as compared to the control mice. Furthermore, treatment with ME decreased the levels of serum aspartate aminotransferase, alanine aminotransferase, triglyceride and total cholesterol that increase with ageing. The hepatoprotective effect of ME appeared to occur through a mechanism related to regulation of the mitogen-activated protein kinases and activation of the nuclear factor-erythroid 2 related factor 2, where the latter regulates the induction of phase 2 antioxidant enzymes and reduction of oxidative damage. Overall, supplementation of ME might be advantageous to the induction of an antioxidant defense system and for the improvement of memory deterioration in ageing animals. (C) 2010 Elsevier Inc. All rights reserved.
C1 [Shih, Ping-Hsiao; Yen, Gow-Chin] Natl Chung Hsing Univ, Dept Food Sci & Biotechnol, Taichung 40227, Taiwan.
   [Chan, Yin-Ching; Wang, Ming-Fu] Providence Univ, Dept Food & Nutr, Taichung 43301, Taiwan.
   [Liao, Jiunn-Wang] Natl Chung Hsing Univ, Grad Inst Vet Pathol, Taichung 40227, Taiwan.
C3 National Chung Hsing University; Providence University - Taiwan;
   National Chung Hsing University
RP Yen, GC (corresponding author), Natl Chung Hsing Univ, Dept Food Sci & Biotechnol, Taichung 40227, Taiwan.
EM gcyen@nchu.edu.tw
RI Shih, Ping-Hsiao/GPG-2472-2022; Liao, Jun/JUF-2784-2023; Yen,
   Gow-Chin/B-7886-2009
OI Chan, Yin Ching/0000-0001-9602-0775; Yen, Gow-Chin/0000-0001-9538-4219;
   Shih, Ping-Hsiao/0000-0002-8387-105X; Liao,
   Jiunn-Wang/0000-0001-7374-1203
FU National Science Council, Taiwan, Republic of China
   [NSC95-2313-B-005-066-MY3]
FX This research was partially supported by the National Science Council
   (NSC95-2313-B-005-066-MY3), Taiwan, Republic of China.
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NR 53
TC 156
Z9 185
U1 0
U2 85
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0955-2863
EI 1873-4847
J9 J NUTR BIOCHEM
JI J. Nutr. Biochem.
PD JUL
PY 2010
VL 21
IS 7
BP 598
EP 605
DI 10.1016/j.jnutbio.2009.03.008
PG 8
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA 618NS
UT WOS:000279363200005
PM 19443193
DA 2025-06-11
ER

PT J
AU Negro, F
   Sanyal, AJ
AF Negro, Francesco
   Sanyal, Arun J.
TI Hepatitis C virus, steatosis and lipid abnormalities: clinical and
   pathogenic data
SO LIVER INTERNATIONAL
LA English
DT Article
DE hepatic fibrosis; hepatitis C virus; lipids; steatosis
ID FATTY LIVER-DISEASE; PROLIFERATOR-ACTIVATED RECEPTOR; TRIGLYCERIDE
   TRANSFER PROTEIN; CORE PROTEIN; INSULIN-RESISTANCE; OXIDATIVE STRESS;
   GENE-EXPRESSION; ROS PRODUCTION; ACCUMULATION; CHOLESTEROL
AB Abnormal accumulation of fat in the liver (steatosis) is commonly observed in hepatitis C virus (HCV) infection, and the severity of steatosis has been well correlated with the degree of hepatic fibrosis. In patients with chronic HCV infection, steatosis may occur in conjunction with other metabolic risk factors such as insulin resistance and the metabolic syndrome. This was observed primarily in patients infected with non-genotype 3 virus. Otherwise, in HCV-infected patients, especially those infected with genotype 3a, reductions in total cholesterol as well as high-density lipoprotein and low-density lipoprotein cholesterol are observed compared with matched controls, and the normalization of these parameters appears to be an important correlate of the response to antiviral therapy. In that setting, the pathogenic mechanisms involved in HCV-induced steatosis are mediated in large part by the HCV core protein, whose expression is associated with lipid droplet accumulation, changes in lipogenic gene expression and/or the activity of lipogenic proteins, and effects on mitochondrial oxidative function. The importance of genes such as peroxisome proliferator-activated receptor-alpha and the proteasome activator PA28-gamma in HCV-mediated steatosis has been elucidated from studies in genetically altered mice, and the manipulation of these and other pathways may provide an avenue for therapeutic intervention.
C1 [Negro, Francesco] Univ Hosp, Div Gastroenterol, Viropathol Unit, CH-1211 Geneva 14, Switzerland.
   [Sanyal, Arun J.] Virginia Commonwealth Univ, Med Ctr, Richmond, VA USA.
C3 University of Geneva; Virginia Commonwealth University
RP Negro, F (corresponding author), Univ Hosp, Div Gastroenterol, Viropathol Unit, 24 Rue Micheli du Crest, CH-1211 Geneva 14, Switzerland.
EM francesco.negro@hcuge.ch
RI Negro, Francesco/E-2183-2012
FU Swiss National Science Foundation [3200B0-103727/1, 320000-116544]
FX This work was supported by the Swiss National Science Foundation (grants
   number 3200B0-103727/1 and 320000-116544) to F. N.
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NR 46
TC 149
Z9 161
U1 0
U2 19
PU WILEY-BLACKWELL PUBLISHING, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1478-3223
J9 LIVER INT
JI Liver Int.
PD MAR
PY 2009
VL 29
BP 26
EP 37
DI 10.1111/j.1478-3231.2008.01950.x
PG 12
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 399WJ
UT WOS:000262829700004
PM 19187070
OA Bronze
DA 2025-06-11
ER

PT J
AU Bernhardt, P
   Levenson, B
   Engels, T
   Strohm, O
AF Bernhardt, P.
   Levenson, B.
   Engels, T.
   Strohm, O.
TI Contrast-enhanced adenosine-stress magnetic resonance imaging -
   Feasibility and practicability of a protocol for detection or exclusion
   of ischemic heart disease in an outpatient setting
SO CLINICAL RESEARCH IN CARDIOLOGY
LA English
DT Article
DE coronary heart disease; myocardial perfusion; stress; magnetic resonance
   imaging
ID POSITRON-EMISSION-TOMOGRAPHY; CORONARY-ARTERY-DISEASE;
   MYOCARDIAL-INFARCTION; SYNDROME-X; PERFUSION; VIABILITY; RESERVE;
   ANGINA; SPECT; MRI
AB Evaluating myocardial function, assessing ischemic myocardial areas and detecting myocardial viability are necessary diagnostic information for guiding further therapy in patients with angina. The aim of this study was to show feasibility and safety of a compiled contrast- enhanced magnetic resonance imaging (ceMRI) protocol providing the above mentioned diagnostic possibilities and to demonstrate its applicability in daily routine.
   Consecutive patients with angina were screened on a 1.5 Tesla system. Functional images in short and long axis orientation were acquired for each patient. First-pass kinetics of a gadolinium-based contrast agent (0.1 mmol/kg) were measured after three minutes of stress with adenosine infusion (140 mu g/kg/min). 10 min after a second bolus injection of contrast agent "late enhancement" (MLE) sequences were acquired for the detection of myocardial necrosis.
   We enrolled 3174 patients referred for ceMRI for detection or exclusion of ischemic heart disease. One patient experienced a major complication due to hyperventilation followed by grand mal seizure. In 1121 (35.3%) patients minor complications, such as mild chest pain or dyspnea (30%), temporarily and asymptomatic AV block (3%) or nausea (2%) could be observed under adenosine infusion. Hypoperfusion in more than one myocardial segment and affecting more than 1/3 of the myocardial wall diameter could be detected in 1972 (62%) patients. Subendocardial hypoperfusion with limited duration could be shown in 897 (28%) patients. In 305 (10%) patients hypoperfusion could be excluded. MLE could be seen in 532 (17%) patients.
   This compiled ceMRI protocol is suitable for detection or exclusion of ischemic heart disease in an outpatient routine. We showed feasibility, applicability and safety of our protocol. CeMRI may serve as a useful surrogate for non-invasive diagnostics prior to invasive coronary angiography in many outpatients.
C1 Hosp Agatharied, D-83734 Hausham, Germany.
   Univ Munich, Krankenhaus Agatharied, Akad Lehrkrankenhaus, Munich, Germany.
   St Gertrauden Hosp, Herzkatheter Praxis, Berlin, Germany.
   St Gertrauden Hosp, MRT Zentrum, Berlin, Germany.
C3 University of Munich
RP Bernhardt, P (corresponding author), Hosp Agatharied, St Agatha Str 1, D-83734 Hausham, Germany.
EM bernhardt@herzmrt.de
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NR 28
TC 7
Z9 7
U1 0
U2 0
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1861-0684
EI 1861-0692
J9 CLIN RES CARDIOL
JI Clin. Res. Cardiol.
PD SEP
PY 2006
VL 95
IS 9
BP 461
EP 467
DI 10.1007/s00392-006-0410-y
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 077VK
UT WOS:000240059100002
PM 16830268
DA 2025-06-11
ER

PT J
AU Grudell, ABM
   Sweetser, S
   Camilleri, M
   Eckert, DJ
   Vazquez-Roque, MI
   Carlson, PJ
   Burton, DD
   Braddock, AE
   Clark, MM
   Graszer, KM
   Kalsy, SA
   Zinsmeister, AR
AF Grudell, April B. M.
   Sweetser, Seth
   Camilleri, Michael
   Eckert, Deborah J.
   Vazquez-Roque, Maria I.
   Carlson, Paula J.
   Burton, Duane D.
   Braddock, Autumn E.
   Clark, Matthew M.
   Graszer, Karen M.
   Kalsy, Sarah A.
   Zinsmeister, Alan R.
TI A controlled pharmacogenetic trial of sibutramine on weight loss and
   body composition in obese or overweight adults
SO GASTROENTEROLOGY
LA English
DT Article
ID FUNCTIONAL GASTROINTESTINAL DISORDERS; GENE PROMOTER POLYMORPHISM;
   RECEPTOR GENE; METABOLIC SYNDROME; ASSOCIATION; SEROTONIN; THERAPY;
   ANXIETY; NOREPINEPHRINE; INVOLVEMENT
AB Background & Aims: Weight loss in response to sibutramine is highly variable. We assessed the association of specific markers of polymorphisms of candidate alpha 2A adrenoreceptor, S-HT transporter, and GN beta 3 genes and weight loss with sibutramine. Methods: We conducted a randomized, double-blind, pharmacogenetic study of behavioral therapy and sibutramine (10 or 15 mg daily) or placebo for 12 weeks in 181 overweight or obese participants. We measured body weight, body mass index, body composition, gastric emptying, and genetic variation (alpha 2A C1291G, 5-HTTLPR, and GN beta 3 C825T genotypes). Analysis of covariance was used to assess treatment effects on and associations of the specific markers of candidate genes with weight loss and body composition. Result: Sibutramine, 10 and 15 mg, caused weight loss (P = .009); there was a statistically significant gene by dose interaction for GN beta 3 genotype. For each candidate gene, significant treatment effects at 12 weeks were observed (P < .017) for all specific genotype variants (Delta weight loss in the 2 sibutramine doses vs placebo): alpha 2A CC (Delta, similar to 5 kg), GN beta 3 TC/TT (Delta, similar to 6 kg), and 5-HTTLPR LS/SS (Delta, similar to 4.5 kg). Gene pairs resulted in significantly greater sibutramine treatment effects on weight (both P < .002): in participants with 5-HTTLPR LS/SS with GN beta 3 TC/TT; Delta, similar to 6 kg and those with alpha 2A CC with GN beta 3 TC/TT; Delta, similar to 8 kg; however, effects were not synergistic. Treatment with sibutramine also resulted in significantly greater reduction of body fat for specific alpha 2A CC and GN beta 3 TC/TT genotype variants individually (both P < .02). Conclusions: Patient selection based on candidate genes may enhance response to multidimensional sibutramine and behavioral therapy for obesity.
C1 [Grudell, April B. M.; Sweetser, Seth; Camilleri, Michael; Eckert, Deborah J.; Vazquez-Roque, Maria I.; Carlson, Paula J.; Burton, Duane D.] Mayo Clin, CENTER, Rochester, MN 55905 USA.
   [Zinsmeister, Alan R.] Mayo Clin, Div Biostat, Dept Hlth Sci Res, Rochester, MN 55905 USA.
   [Braddock, Autumn E.; Clark, Matthew M.; Graszer, Karen M.; Kalsy, Sarah A.] Mayo Clin, Dept Psychiat & Psychol, Rochester, MN 55905 USA.
C3 Mayo Clinic; Mayo Clinic; Mayo Clinic
RP Camilleri, M (corresponding author), Mayo Clin, CENTER, Charlton 8-110,200 First St,SW, Rochester, MN 55905 USA.
EM camilleri.michael@mayo.edu
RI Camilleri, Michael/AGD-8232-2022
FU National Institutes of Health grants [R01 DK 67071, K24 DK 02638,
   RR024150]; Public Health Service [DK50456]
FX Supported in part by National Institutes of Health grants R01 DK 67071
   and K24 DK 02638 (to M.C.); by NIH grant RR024150, which supports the
   Mayo Clinical Research Unit; and, for DEXA measurements, by Public
   Health Service grant DK50456, which funds the Minnesota Obesity
   Center.The authors thank the Nursing Core of the Mayo Clinic CTSA
   Clinical Research Unit and Cindy Stanislav for secretarial
   assistance.Registration number of clinical trial at Clinical Trials.gov:
   NCT 00433641.
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NR 46
TC 45
Z9 47
U1 0
U2 4
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0016-5085
J9 GASTROENTEROLOGY
JI Gastroenterology
PD OCT
PY 2008
VL 135
IS 4
BP 1142
EP 1154
DI 10.1053/j.gastro.2008.07.009
PG 13
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 359JM
UT WOS:000259982800021
PM 18725220
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Kwok, ZCM
   Tao, A
   Chan, HYL
AF Kwok, Zoe Ching-Man
   Tao, An
   Chan, Helen Yue-Lai
TI Effects of Health Coaching on Cardiometabolic Health in Middle-Aged
   Adults: A Systematic Review and Meta-analysis
SO AMERICAN JOURNAL OF HEALTH PROMOTION
LA English
DT Review
DE cardiometabolic disease; health coaching; health risk change; lifestyle
   change; middle-aged adults; physical activity; systematic review;
   primary care
ID MENOPAUSAL SYMPTOMS; RISK; DISEASE; INTERVENTION; STROKE
AB Objective To appraise and synthesize evidence on the effects of health coaching as the primary intervention on cardiometabolic health among middle-aged adults. Data Source Six electronic databases (MEDLINE, Embase, PsycINFO, CINAHL, PubMed, and the Cochrane library) were searched from inception until July 2021. Study Inclusion and Exclusion Criteria Randomized controlled trials and controlled clinical trials published in English, reporting health coaching aimed to promote behavioral changes for improving cardiometabolic health among middle-aged adults were included. Studies on health coaching as secondary intervention were excluded. Data Extraction Two reviewers selected the articles, appraised the study quality, and extracted data independently. All kinds of outcomes related to cardiometabolic health, including health behaviors, psychological and physiological outcomes, were included. Data Synthesis Meta-analysis was performed if three or more studies reported the same outcomes. Narrative synthesis was performed if pooling of data for meta-analysis was not feasible. Results Eight studies were reviewed. Most studies involved substantial risk of bias. The majority of the participants were women (99.1%). Meta-analysis showed a small but significant effect of health coaching on increasing physical activity (SMD = .34, 95% CI = .08-.60, p = .01, I-2 = 0%); however, its effect on perceived barriers to physical activity and depressive symptoms was nonsignificant. Narrative synthesis yielded inconsistent results on diet, smoking, anxiety, goal achievement and self-efficacy for behavioral change, physiological outcomes, and metabolic syndrome severity, and nonsignificant effects on alcohol consumption, sleep quality, perceived benefits of physical activities, and cardiovascular symptoms. Conclusions Health coaching has significant effects on increasing physical activity among middle-aged adults; however, its effects on health behaviors and risk factors related to cardiometabolic health are inconclusive. Further efforts are warranted to examine how health coaching can improve cardiometabolic health among middle-aged adults.
C1 [Kwok, Zoe Ching-Man; Tao, An; Chan, Helen Yue-Lai] Chinese Univ Hong Kong, Fac Med, Nethersole Sch Nursing, Hong Kong, Peoples R China.
C3 Chinese University of Hong Kong
RP Kwok, ZCM (corresponding author), Chinese Univ Hong Kong, Fac Med, Nethersole Sch Nursing, Shatin, 8-F Esther Lee Bldg, Hong Kong, Peoples R China.
EM zoekwok@cuhk.edu.hk
RI Kwok, Ching Man Zoe/IXX-1928-2023
OI Tao, An/0000-0002-3157-1362; Kwok, Zoe/0000-0002-0926-7137
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NR 36
TC 6
Z9 6
U1 2
U2 7
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0890-1171
EI 2168-6602
J9 AM J HEALTH PROMOT
JI Am. J. Health Promot.
PD MAY
PY 2023
VL 37
IS 4
BP 555
EP 565
DI 10.1177/08901171221137332
EA NOV 2022
PG 11
WC Public, Environmental & Occupational Health
WE Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA KP7Y6
UT WOS:000878352700001
PM 36322092
DA 2025-06-11
ER

PT J
AU Laemmerer, A
   Lehmann, C
   Mayr, L
   Bruckner, K
   Gabler, L
   Senfter, D
   Meyer, P
   Balber, T
   Pirker, C
   Jaunecker, CN
   Kirchhofer, D
   Vician, P
   Griesser, M
   Spiegl-Kreinecker, S
   Schmook, MT
   Traub-Weidinger, T
   Kuess, P
   Eckert, F
   Federico, A
   Madlener, S
   Stepien, N
   Robl, B
   Baumgartner, A
   Hainfellner, JA
   Dieckmann, K
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   Corsini, NS
   Holzmann, K
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   Haberler, C
   Beck, A
   Pfister, SM
   Schueler, J
   Lötsch-Gojo, D
   Knoblich, JA
   Berger, W
   Gojo, J
AF Laemmerer, Anna
   Lehmann, Christian
   Mayr, Lisa
   Bruckner, Katharina
   Gabler, Lisa
   Senfter, Daniel
   Meyer, Philipp
   Balber, Theresa
   Pirker, Christine
   Jaunecker, Carola N.
   Kirchhofer, Dominik
   Vician, Petra
   Griesser, Michelle
   Spiegl-Kreinecker, Sabine
   Schmook, Maria T.
   Traub-Weidinger, Tatjana
   Kuess, Peter
   Eckert, Franziska
   Federico, Aniello
   Madlener, Sibylle
   Stepien, Natalia
   Robl, Bernhard
   Baumgartner, Alicia
   Hainfellner, Johannes A.
   Dieckmann, Karin
   Dorfer, Christian
   Roessler, Karl
   Corsini, Nina S.
   Holzmann, Klaus
   Schmidt, Wolfgang M.
   Peyrl, Andreas
   Azizi, Amedeo A.
   Haberler, Christine
   Beck, Alexander
   Pfister, Stefan M.
   Schueler, Julia
   Loetsch-Gojo, Daniela
   Knoblich, Juergen A.
   Berger, Walter
   Gojo, Johannes
TI Alternative lengthening of telomere-based immortalization renders
   H3G34R-mutant diffuse hemispheric glioma hypersensitive to PARP
   inhibitor combination regimens
SO NEURO-ONCOLOGY
LA English
DT Article
DE ATRX; DNA damage; diffuse hemispheric glioma; PARP inhibitor
ID PEDIATRIC HIGH-GRADE; CANCER; TEMOZOLOMIDE; SENSITIVITY;
   MEDULLOBLASTOMA; RESISTANCE; MUTATIONS; PATIENT; H3K9ME3; GENES
AB Background Diffuse hemispheric glioma, H3 G34R/V-mutant (DHG-H3G34) is characterized by poor prognosis and lack of effective treatment options. DHG-H3G34R further harbor deactivation of alpha-thalassemia/mental retardation syndrome X-linked protein (ATRX; DHG-H3G34R_ATRX) suggesting a unique interaction of these 2 oncogenic alterations. In this study, we dissect their cell biological interplay, investigate the impact on telomere stabilization, and consequently validate a targeted therapy approach.Methods We characterized patient-derived primary pediatric high-grade glioma (pHGG) models for telomere-maintenance mechanisms, DNA damage stress (including protein expression, pH2AX/Rad51 foci, cell-cycle arrest) and their sensitivity towards poly-ADP ribose polymerase inhibitor (PARPi) combinations. Human induced pluripotent stem cells (iPSCs) were used for modeling the disease. The anticancer activity of PARPi combinations in vivo was studied in Chorioallantoic Membrane (CAM) and orthotopic in vivo experiments. Finally, we treated a DHG-H3G34R_ATRX patient with PARPi combination therapy.Results We elaborate that alternative lengthening of telomeres (ALT) is a key characteristic of DHG-H3G34R_ATRX. A dominant cooperative effect between H3G34R and ATRX loss in ALT activation also became apparent in iPSCs, which endogenously exert telomerase activity. In both, patient-derived DHG-H3G34R_ATRX models and H3G34R+/ATRX- iPSCs, the ALT-phenotype was associated with increased basal DNA damage stress, mediating synergistic susceptibility towards PARPi (talazoparib, niraparib) combinations with topoisomerase-I inhibitors (topotecan, irinotecan). In a first-of-its-kind case, treatment of a DHG-H3G34R_ATRX patient with the brain-penetrant PARP inhibitor niraparib and topotecan resulted in significant tumor reduction.Conclusions Our preclinical and clinical data strongly support the further development of PARPi together with DNA damage stress-inducing treatment regimens for DHG-H3G34R_ATRX.
C1 [Laemmerer, Anna; Gabler, Lisa; Pirker, Christine; Jaunecker, Carola N.; Kirchhofer, Dominik; Vician, Petra; Holzmann, Klaus; Berger, Walter] Med Univ Vienna, Ctr Canc Res, Vienna, Austria.
   [Laemmerer, Anna; Gabler, Lisa; Pirker, Christine; Jaunecker, Carola N.; Kirchhofer, Dominik; Vician, Petra; Holzmann, Klaus; Berger, Walter] Med Univ Vienna, Comprehens Canc Ctr, Vienna, Austria.
   [Laemmerer, Anna; Mayr, Lisa; Bruckner, Katharina; Senfter, Daniel; Madlener, Sibylle; Stepien, Natalia; Robl, Bernhard; Baumgartner, Alicia; Peyrl, Andreas; Azizi, Amedeo A.; Gojo, Johannes] Med Univ Vienna, Comprehens Canc Ctr, Dept Pediat & Adolescent Med, Vienna, Austria.
   [Laemmerer, Anna; Mayr, Lisa; Bruckner, Katharina; Senfter, Daniel; Madlener, Sibylle; Stepien, Natalia; Robl, Bernhard; Baumgartner, Alicia; Peyrl, Andreas; Azizi, Amedeo A.; Gojo, Johannes] Med Univ Vienna, Comprehens Ctr Pediat, Vienna, Austria.
   [Lehmann, Christian; Corsini, Nina S.; Knoblich, Juergen A.] Austrian Acad Sci, IMBA Inst Mol Biotechnol, Vienna Bioctr VBC, Vienna, Austria.
   [Lehmann, Christian] Univ Vienna, Doctoral Sch, PhD Program, Vienna Bioctr VBC, Vienna, Austria.
   [Lehmann, Christian] Med Univ Vienna, Vienna, Austria.
   [Bruckner, Katharina; Gabler, Lisa; Dorfer, Christian; Roessler, Karl; Loetsch-Gojo, Daniela] Med Univ Vienna, Comprehens Canc Ctr, Dept Neurosurg, Vienna, Austria.
   [Meyer, Philipp; Schueler, Julia] Charles River Labs Germany GmbH, Freiburg, Germany.
   [Balber, Theresa; Traub-Weidinger, Tatjana] Med Univ Vienna, Dept Biomed Imaging & Image Guided Therapy, Div Nucl Med, Vienna, Austria.
   [Balber, Theresa] Med Univ Vienna, Univ Vienna, Joint Appl Med Radiochem Facil, Vienna, Austria.
   [Griesser, Michelle; Spiegl-Kreinecker, Sabine] Johannes Kepler Univ Linz, Kepler Univ Hosp GmbH, Dept Neurosurg, Linz, Austria.
   [Schmook, Maria T.] Med Univ Vienna, Dept Biomed Imaging & Image Guided Therapy, Div Neuroradiol & Musculoskeletal Radiol, Vienna, Austria.
   [Kuess, Peter; Eckert, Franziska; Dieckmann, Karin] Med Univ Vienna, Dept Radiat Oncol, Vienna, Austria.
   [Federico, Aniello; Pfister, Stefan M.] Hopp Childrens Canc Ctr KiTZ, Heidelberg, Germany.
   [Federico, Aniello; Pfister, Stefan M.] German Canc Res Ctr, Div Pediat Neurooncol, Heidelberg, Germany.
   [Federico, Aniello; Pfister, Stefan M.] German Canc Consortium DKTK, Heidelberg, Germany.
   [Federico, Aniello; Pfister, Stefan M.] Natl Ctr Tumor Dis NCT, Heidelberg, Germany.
   [Hainfellner, Johannes A.; Haberler, Christine] Med Univ Vienna, Dept Neurol, Div Neuropathol & Neurochem, Vienna, Austria.
   [Schmidt, Wolfgang M.] Med Univ Vienna, Ctr Anat & Cell Biol, Div Cell & Dev Biol, Vienna, Austria.
   [Beck, Alexander] Ludwig Maximilians Univ Munchen, Ctr Neuropathol, Munich, Germany.
   [Pfister, Stefan M.] Heidelberg Univ Hosp, Dept Pediat Hematol & Oncol, Heidelberg, Germany.
   [Knoblich, Juergen A.] Med Univ Vienna, Dept Neurol, Vienna, Austria.
C3 Medical University of Vienna; Medical University of Vienna; Medical
   University of Vienna; Medical University of Vienna; Austrian Academy of
   Sciences; Vienna Biocenter (VBC); Institute of Molecular Biotechnology
   (IMBA); University of Vienna; Vienna Biocenter (VBC); Medical University
   of Vienna; Medical University of Vienna; Medical University of Vienna;
   Medical University of Vienna; University of Vienna; Johannes Kepler
   University Linz; Medical University of Vienna; Medical University of
   Vienna; Helmholtz Association; German Cancer Research Center (DKFZ);
   Helmholtz Association; German Cancer Research Center (DKFZ); Helmholtz
   Association; German Cancer Research Center (DKFZ); Ruprecht Karls
   University Heidelberg; National Center for Tumor Diseases; Medical
   University of Vienna; Medical University of Vienna; University of
   Munich; Ruprecht Karls University Heidelberg; Medical University of
   Vienna
RP Berger, W (corresponding author), Med Univ Vienna, Chair Appl & Expt Oncol, Ctr Canc Res, Vienna, Austria.; Gojo, J (corresponding author), Med Univ Vienna, Dept Pediat & Adolescent Med, Pediat Neurooncol, Vienna, Austria.
EM walter.berger@meduniwien.ac.at; johannes.gojo@meduniwien.ac.at
RI Gabler, Lisa/KFS-6436-2024; Rössler, Karl/AAN-5096-2021; Holzmann,
   Klaus/I-4437-2019; Knoblich, Juergen/C-2974-2015; Dorfer,
   Christian/ACX-8758-2022; Berger, Walter/AFQ-9733-2022; Kuess,
   Peter/AAT-1178-2020; Pfister, Stefan/F-6860-2013; Eckert,
   Franziska/KHW-2887-2024; Madlener, Sibylle/HPG-2860-2023
OI Gojo, Johannes/0000-0002-8113-3416; Lehmann,
   Christian/0000-0002-6220-619X; Holzmann, Klaus/0000-0003-4077-3377;
   Lammerer, Anna/0000-0001-9524-585X
FU Austrian Science fund [4164, 906-B28]; German National Funding
   Organization BMBF ("BRCAddict") [TRS-2018-00000714]; German National
   Funding Organization BMBF ("BRCAddict"); ITCC-P4 consortium, an
   Innovative Medicines Initiative 2 Joint Undertaking [116064]; ITCC-P4
   consortium, an Innovative Medicines Initiative 2 Joint Undertaking;
   European Union; European Union; European Federation of Pharmaceutical
   Industries and Associations; European Federation of Pharmaceutical
   Industries and Associations; Physician Researcher Pathway scholarship of
   the Medical University of Vienna; Physician Researcher Pathway
   scholarship of the Medical University of Vienna; Oncomine Clinical
   Research Grant 2020; Oncomine Clinical Research Grant 2020; Verein
   unser_kind; Verein unser_kind; Forschungsgesellschaft fur Zerebrale
   Tumore; Forschungsgesellschaft fur Zerebrale Tumore; City of Vienna Fund
   for Innovative Interdisciplinary Cancer Research [21128]; City of Vienna
   Fund for Innovative Interdisciplinary Cancer Research; Research Program
   of the Austrian Science Fund FWF; Research Program of the Austrian
   Science Fund FWF
FX This study was supported by the Austrian Science fund (TRANSCAN-2
   "BRCAddict" project #I 4164 to JG, project #T906-B28 to DLG) and the
   German National Funding Organization BMBF ("BRCAddict" project
   #TRS-2018-00000714, under the umbrella of the TRANSCAN-2 call #JTC
   2017). The project was supported by the ITCC-P4 consortium, an
   Innovative Medicines Initiative 2 Joint Undertaking under grant
   agreement No. 116064. This Joint Undertaking receives support from the
   European Union's Horizon 2020 research and innovation program and the
   European Federation of Pharmaceutical Industries and Associations.
   Further, the Physician Researcher Pathway scholarship of the Medical
   University of Vienna (granted to LM), Oncomine Clinical Research Grant
   2020 (S.M.), the "Verein unser_kind" and the "Forschungsgesellschaft fur
   Zerebrale Tumore" and the "City of Vienna Fund for Innovative
   Interdisciplinary Cancer Research" (project #21128 to LG) supported this
   study. Work in J.A.K.'s laboratory is supported by a Research Program of
   the Austrian Science Fund FWF (SFBF78 Stem Cell, F 7803-B).
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NR 64
TC 2
Z9 2
U1 0
U2 0
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1522-8517
EI 1523-5866
J9 NEURO-ONCOLOGY
JI Neuro-Oncology
PD NOV 18
PY 2024
VL 27
IS 3
BP 811
EP 827
DI 10.1093/neuonc/noae228
EA DEC 2024
PG 17
WC Oncology; Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Neurosciences & Neurology
GA Z5P1B
UT WOS:001373194600001
PM 39556024
OA hybrid
DA 2025-06-11
ER

PT J
AU Nicolas, S
   Léime, CSO
   Hoban, AE
   Hueston, CM
   Cryan, JF
   Nolan, YM
AF Nicolas, Sarah
   Leime, Ciaran S. O.
   Hoban, Alan E.
   Hueston, Cara M.
   Cryan, John F.
   Nolan, Yvonne M.
TI Enduring effects of an unhealthy diet during adolescence on systemic but
   not neurobehavioural measures in adult rats
SO NUTRITIONAL NEUROSCIENCE
LA English
DT Article
DE Adolescence; diet; inflammation; metabolism; IL-1 beta; hippocampus;
   cognition; anxiety
ID HIGH-FAT DIET; OBJECT RECOGNITION; METABOLIC SYNDROME; CAFETERIA DIET;
   HIPPOCAMPAL NEUROGENESIS; GENE-EXPRESSION; SPATIAL MEMORY; BRAIN;
   INFLAMMATION; EXPOSURE
AB Introduction:Adolescence is an important stage of maturation for various brain structures. It is during this time therefore that the brain may be more vulnerable to environmental factors such as diet that may influence mood and memory. Diets high in fat and sugar (termed a cafeteria diet) during adolescence have been shown to negatively impact upon cognitive performance, which may be reversed by switching to a standard diet during adulthood. Consumption of a cafeteria diet increases both peripheral and central levels of interleukin-1 beta (IL-1 beta), a pro-inflammatory cytokine which is also implicated in cognitive impairment during the ageing process. It is unknown whether adolescent exposure to a cafeteria diet potentiates the negative effects of IL-1 beta on cognitive function during adulthood. Methods:Male Sprague-Dawley rats consumed a cafeteria diet during adolescence after which time they received a lentivirus injection in the hippocampus to induce chronic low-grade overexpression of IL-1 beta. After viral integration, metabolic parameters, circulating and central pro-inflammatory cytokine levels, and cognitive behaviours were assessed. Results:Our data demonstrate that rats fed the cafeteria diet exhibit metabolic dysregulations in adulthood, which were concomitant with low-grade peripheral and central inflammation. Overexpression of hippocampal IL-1 beta in adulthood impaired spatial working memory. However, adolescent exposure to a cafeteria diet, combined with or without hippocampal IL-1 beta in adulthood did not induce any lasting cognitive deficits when the diet was replaced with a standard diet in adulthood. Discussion: These data demonstrate that cafeteria diet consumption during adolescence induces metabolic and inflammatory changes, but not behavioural changes in adulthood.
C1 [Nicolas, Sarah; Leime, Ciaran S. O.; Hoban, Alan E.; Hueston, Cara M.; Cryan, John F.; Nolan, Yvonne M.] Univ Coll Cork, Dept Anat & Neurosci, Cork, Ireland.
   [Cryan, John F.; Nolan, Yvonne M.] Univ Coll Cork, APC Microbiome Ireland, Cork, Ireland.
C3 University College Cork; University College Cork
RP Nolan, YM (corresponding author), Univ Coll Cork, Dept Anat & Neurosci, Cork, Ireland.; Nolan, YM (corresponding author), Univ Coll Cork, APC Microbiome Ireland, Cork, Ireland.
EM y.nolan@ucc.ie
RI Cryan, John/A-6950-2013
OI Nicolas, Sarah/0000-0002-2581-3484; Nolan, Yvonne/0000-0003-2426-234X;
   Hueston, Cara/0000-0002-3442-9441; Leime, Ciaran/0000-0002-7420-4159;
   Cryan, John/0000-0001-5887-2723
FU Science Foundation Ireland (SFI) [SFI/IA/1537]; Irish Research Council
   [GOIPD/2018/550]
FX This work was funded by Science Foundation Ireland (SFI) under Grant
   Number SFI/IA/1537. Sarah Nicolas is recipient of an Irish Research
   Council Postdoctoral Fellowship (GOIPD/2018/550).
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NR 57
TC 8
Z9 9
U1 0
U2 5
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1028-415X
EI 1476-8305
J9 NUTR NEUROSCI
JI Nutr. Neurosci.
PD APR 3
PY 2022
VL 25
IS 4
BP 657
EP 669
DI 10.1080/1028415X.2020.1796041
EA JUL 2020
PG 13
WC Neurosciences; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Nutrition & Dietetics
GA ZW7ZC
UT WOS:000553445800001
PM 32723167
OA Green Published
DA 2025-06-11
ER

PT J
AU Gutiérrez-Esparza, G
   Pulido, T
   Martínez-Garcia, M
   Ramírez-delReal, T
   Groves-Miralrio, LE
   Márquez-Murillo, MF
   Amezcua-Guerra, LM
   Vargas-Alarcón, G
   Hernández-Lemus, E
AF Gutierrez-Esparza, Guadalupe
   Pulido, Tomas
   Martinez-Garcia, Mireya
   Ramirez-delReal, Tania
   Groves-Miralrio, Lucero E.
   Marquez-Murillo, Manlio F.
   Amezcua-Guerra, Luis M.
   Vargas-Alarcon, Gilberto
   Hernandez-Lemus, Enrique
TI A machine learning approach to personalized predictors of dyslipidemia:
   a cohort study
SO FRONTIERS IN PUBLIC HEALTH
LA English
DT Article
DE hypertriglyceridemia; hypercholesterolemia; hypoalphalipoproteinemia;
   mixed hyperlipidemias; feature selection; machine learning; Tlalpan 2020
   cohort; Mexico City
ID URIC-ACID LEVELS; HIGH-DENSITY-LIPOPROTEIN; CORONARY-HEART-DISEASE;
   METABOLIC SYNDROME; HYPERTRIGLYCERIDEMIC WAIST; RISK-FACTORS;
   CONSUMPTION; SLEEP; CHOLESTEROL; HYPERCHOLESTEROLEMIA
AB Introduction: Mexico ranks second in the global prevalence of obesity in the adult population, which increases the probability of developing dyslipidemia. Dyslipidemia is closely related to cardiovascular diseases, which are the leading cause of death in the country. Therefore, developing tools that facilitate the prediction of dyslipidemias is essential for prevention and early treatment. Methods: In this study, we utilized a dataset from a Mexico City cohort consisting of 2,621 participants, men and women aged between 20 and 50 years, with and without some type of dyslipidemia. Our primary objective was to identify potential factors associated with different types of dyslipidemia in both men and women. Machine learning algorithms were employed to achieve this goal. To facilitate feature selection, we applied the Variable Importance Measures (VIM) of Random Forest (RF), XGBoost, and Gradient Boosting Machine (GBM). Additionally, to address class imbalance, we employed Synthetic Minority Over-sampling Technique (SMOTE) for dataset resampling. The dataset encompassed anthropometric measurements, biochemical tests, dietary intake, family health history, and other health parameters, including smoking habits, alcohol consumption, quality of sleep, and physical activity. Results: Our results revealed that the VIM algorithm of RF yielded the most optimal subset of attributes, closely followed by GBM, achieving a balanced accuracy of up to 80%. The selection of the best subset of attributes was based on the comparative performance of classifiers, evaluated through balanced accuracy, sensitivity, and specificity metrics. Discussion: The top five features contributing to an increased risk of various types of dyslipidemia were identified through the machine learning technique. These features include body mass index, elevated uric acid levels, age, sleep disorders, and anxiety. The findings of this study shed light on significant factors that play a role in dyslipidemia development, aiding in the early identification, prevention, and treatment of this condition.
C1 [Gutierrez-Esparza, Guadalupe; Ramirez-delReal, Tania] Mexico CONAHCYT, Natl Council Humanities Sci & Technol, Mexico City, Mexico.
   [Gutierrez-Esparza, Guadalupe; Pulido, Tomas] Natl Inst Cardiol Ignacio Chavez, Clin Res, Mexico City, Mexico.
   [Martinez-Garcia, Mireya; Groves-Miralrio, Lucero E.; Amezcua-Guerra, Luis M.] Natl Inst Cardiol Ignacio Chavez, Dept Immunol, Mexico City, Mexico.
   [Ramirez-delReal, Tania] Ctr Res Geospatial Informat Sci, Aguascalientes, Mexico.
   [Marquez-Murillo, Manlio F.] Natl Inst Cardiol Ignacio Chavez, Dept Electrocardiol, Mexico City, Mexico.
   [Vargas-Alarcon, Gilberto] Natl Inst Cardiol Ignacio Chavez, Dept Mol Biol & Endocrinol, Mexico City, Mexico.
   [Hernandez-Lemus, Enrique] Natl Inst Genom Med, Computat Genom Div, Mexico City, Mexico.
   [Hernandez-Lemus, Enrique] Univ Nacl Autonoma Mexico, Ctr Complex Sci, Mexico City, Mexico.
C3 National Institute of Cardiology - Mexico; National Institute of
   Cardiology - Mexico; National Institute of Cardiology - Mexico; National
   Institute of Cardiology - Mexico; Instituto Nacional de Medicina
   Genomica; Universidad Nacional Autonoma de Mexico
RP Gutiérrez-Esparza, G (corresponding author), Mexico CONAHCYT, Natl Council Humanities Sci & Technol, Mexico City, Mexico.; Gutiérrez-Esparza, G (corresponding author), Natl Inst Cardiol Ignacio Chavez, Clin Res, Mexico City, Mexico.; Hernández-Lemus, E (corresponding author), Natl Inst Genom Med, Computat Genom Div, Mexico City, Mexico.; Hernández-Lemus, E (corresponding author), Univ Nacl Autonoma Mexico, Ctr Complex Sci, Mexico City, Mexico.
EM ggutierreze@conacyt.mx
RI Márquez, Manlio/AAE-3001-2019; Martínez-García, Mireya/AAU-6797-2020;
   Ramirez-delReal, Tania Aglae/ISS-4817-2023
FU This research was supported by the National Council of Humanities,
   Sciences and Technology (CONAHCYT) and Ctedras CONAHCYT (Researchers for
   Mexico).; National Council of Humanities, Sciences and Technology
   (CONAHCYT)
FX This research was supported by the National Council of Humanities,
   Sciences and Technology (CONAHCYT) and Catedras CONAHCYT (Researchers
   for Mexico).r This research was supported by the National Council of
   Humanities, Sciences and Technology (CONAHCYT) and Catedras CONAHCYT
   (Researchers for Mexico).
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NR 138
TC 5
Z9 5
U1 2
U2 13
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 2296-2565
J9 FRONT PUBLIC HEALTH
JI Front. Public Health
PD SEP 20
PY 2023
VL 11
AR 1213926
DI 10.3389/fpubh.2023.1213926
PG 13
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA T7LV2
UT WOS:001079770200001
PM 37799151
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Shipelin, VA
   Trusov, NV
   Apryatin, SA
   Shumakova, AA
   Timonin, AN
   Riger, NA
   Gmoshinski, IV
   Nikityuk, DB
AF Shipelin, Vladimir A.
   Trusov, Nikita V.
   Apryatin, Sergey A.
   Shumakova, Antonina A.
   Timonin, Andrey N.
   Riger, Nikolay A.
   Gmoshinski, Ivan V.
   Nikityuk, Dmintry B.
TI Comprehensive assessment of the effectiveness of l-carnitine and
   transresveratrol in rats with diet-induced obesity
SO NUTRITION
LA English
DT Article
DE Obesity; Rats; Resveratrol; l-carnitine; Cytokines; Adipokines; Behavior
ID GENE-EXPRESSION; METABOLIC SYNDROME; LIPID-METABOLISM; FATTY-ACID;
   RESVERATROL; SUPPLEMENTATION; ADULTS
AB Objectives: Transresveratrol (Res) and l-carnitine (l-Car) are proposed to alleviate metabolic and immune disorders and increase physical activity in obese individuals. This study aims to estimate the effect of Res and l Car in rats with diet-induced obesity.Methods: Male Wistar rats were fed a diet with excess fat and fructose (high-fat high-carbohydrate diet [HFCD]) supplemented with Res and l-Car at doses of 25 and 300 mg/kg of body weight, respectively, for 63 d. An assessment of grip strength, behavioral reactions, as well as biochemical, morphological, and immunological parameters, was performed.Results: Res supplementation did not affect energy consumption, but l-Car increased when animals had free access to feed. Body weight gains were the highest in animals fed the HFCD, lowest in rats receiving the control balanced diet, and intermediate in animals receiving Res and l-Car. Feeding with Res and l-Car canceled the decrease in long-term memory in rats fed the HFCD, as well as reduced anxiety and increased mobility. With both supplements, bilirubin, triglycerides, and low-density lipoprotein levels in the blood plasma returned to normal values, but only l-Car increased the ratio of aspartic and alanine transaminases. In addition, l-Car lowered the levels of leptin and ghrelin and increased transforming growth factor beta 1 in the blood plasma, and consumption of Res was accompanied by a decrease in interleukin-17A and increase in interferon gamma in spleen lysates. Moreover, l-Car reduced the number of cells with lipid inclusions in the liver.Conclusions: The consumption of Res and l-Car leads to a significant reduction in dyslipidemia and inflamma-tion with potentially favorable changes in behavioral responses.(c) 2021 Elsevier Inc. All rights reserved.
C1 [Shipelin, Vladimir A.; Trusov, Nikita V.; Shumakova, Antonina A.; Timonin, Andrey N.; Riger, Nikolay A.; Gmoshinski, Ivan V.; Nikityuk, Dmintry B.] Fed Res Ctr Nutr & Biotechnol, Moscow, Russia.
   [Shipelin, Vladimir A.] Plekhanov Russian Univ Econ, Moscow, Russia.
   [Apryatin, Sergey A.] Inst Expt Med, St Petersburg, Russia.
   [Nikityuk, Dmintry B.] IM Sechenov First Moscow State Med Univ, Moscow, Russia.
C3 Federal Research Center of Nutrition, Biotechnology & Food Safety;
   Plekhanov Russian University of Economics; Institute of Experimental
   Medicine; Sechenov First Moscow State Medical University
RP Shipelin, VA (corresponding author), Fed Res Ctr Nutr & Biotechnol, Moscow, Russia.; Shipelin, VA (corresponding author), Plekhanov Russian Univ Econ, Moscow, Russia.
EM v.shipelin@yandex.ru
RI Apryatin, Sergey/R-5394-2016; Gmoshinski, Ivan/K-6755-2018; Sumakova,
   Antonina/R-8508-2016; Trusov, Nikita/P-1942-2016; Shipelin,
   Vladimir/N-4692-2016
OI Sumakova, Antonina/0000-0003-1373-4436; Trusov,
   Nikita/0000-0002-1919-9297; Shipelin, Vladimir/0000-0002-0015-8735
FU Russian Scientific Foundation [17-16-01043]; Russian Science Foundation
   [17-16-01043] Funding Source: Russian Science Foundation
FX The work was supported by a grant from the Russian Scientific Foundation
   (No. 17-16-01043), entitled "Search for effector units of metabolism
   regulated by alimentary factors in obesity for the development of
   innovative specialized food."
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NR 49
TC 3
Z9 3
U1 1
U2 5
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0899-9007
EI 1873-1244
J9 NUTRITION
JI Nutrition
PD MAR
PY 2022
VL 95
AR 111561
DI 10.1016/j.nut.2021.111561
EA JAN 2022
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 0N1CD
UT WOS:000782583500009
PM 34999386
DA 2025-06-11
ER

PT J
AU Gerdle, B
   Leinhard, OD
   Lund, E
   Bengtsson, A
   Lundberg, P
   Ghafouri, B
   Forsgren, MF
AF Gerdle, Bjorn
   Leinhard, Olof Dahlqvist
   Lund, Eva
   Bengtsson, Ann
   Lundberg, Peter
   Ghafouri, Bijar
   Forsgren, Mikael Fredrik
TI Fibromyalgia: Associations Between Fat Infiltration, Physical Capacity,
   and Clinical Variables
SO JOURNAL OF PAIN RESEARCH
LA English
DT Article
DE body mass index; chronic pain; fibromyalgia; physical fitness; muscle;
   fat; magnetic resonance imaging; body composition
ID CHRONIC WIDESPREAD PAIN; BODY-MASS INDEX; QUALITY-OF-LIFE;
   LOW-BACK-PAIN; METABOLIC SYNDROME; TRAPEZIUS MUSCLE; BLOOD-PRESSURE;
   RHEUMATOID-ARTHRITIS; FUNCTIONAL-CAPACITY; HOSPITAL ANXIETY
AB Background: Obesity is a risk factor for the development of fibromyalgia (FM) and generally most studies report increased Body Mass Index (BMI) in FM. Obesity in FM is associated with a worse clinical presentation. FM patients have low physical conditioning and obesity further exacerbates these aspects. Hitherto studies of FM have focused upon a surrogate for overall measure of fat content, ie, BMI. This study is motivated by that ectopic fat and adipose tissues are rarely investigated in FM including their relationships to physical capacity variables. Moreover, their relationships to clinical variables including are not known. Aims were to 1) compare body composition between FM and healthy controls and 2) investigate if significant associations exist between body composition and physical capacity aspects and important clinical variables.Methods: FM patients (n = 32) and healthy controls (CON; n = 30) underwent a clinical examination that included pressure pain thresholds and physical tests. They completed a health questionnaire and participated in whole-body magnetic resonance imaging (MRI) to determine body composition aspects.Results: Abdominal adipose tissues, muscle fat, and BMI were significantly higher in FM, whereas muscle volumes of quadriceps were smaller. Physical capacity variables correlated negatively with body composition variables in FM. Both body composition and physical capacity variables were significant regressors of group belonging; the physical capacity variables alone showed stronger relationships with group membership. A mix of body composition variables and physical capacity variables were significant regressors of pain intensity and impact in FM. Body composition variables were the strongest regressors of blood pressures, which were increased in FM.Conclusion: Obesity has a negative influence on FM symptomatology and increases the risk for other serious conditions. Hence, obesity, dietary habits, and physical activity should be considered when developing clinical management plans for patients with FM.
C1 [Gerdle, Bjorn; Bengtsson, Ann; Ghafouri, Bijar] Linkoping Univ, Pain & Rehabil Ctr, SE-58183 Linkoping, Sweden.
   [Gerdle, Bjorn; Leinhard, Olof Dahlqvist; Lund, Eva; Bengtsson, Ann; Lundberg, Peter; Ghafouri, Bijar; Forsgren, Mikael Fredrik] Linkoping Univ, Dept Hlth Med & Caring Sci, SE-58183 Linkoping, Sweden.
   [Gerdle, Bjorn; Leinhard, Olof Dahlqvist; Lundberg, Peter; Forsgren, Mikael Fredrik] Ctr Med Image Sci & Visualizat CMIV, SE-58183 Linkoping, Sweden.
   [Leinhard, Olof Dahlqvist; Lund, Eva; Lundberg, Peter; Forsgren, Mikael Fredrik] Linkoping Univ, Dept Radiat Phys, SE-58183 Linkoping, Sweden.
   [Leinhard, Olof Dahlqvist; Forsgren, Mikael Fredrik] AMRA Med AB, Linkoping, Sweden.
C3 Linkoping University; Linkoping University; Linkoping University
RP Gerdle, B (corresponding author), Linkoping Univ, Pain & Rehabil Ctr, SE-58183 Linkoping, Sweden.; Gerdle, B (corresponding author), Linkoping Univ, Dept Hlth Med & Caring Sci, SE-58183 Linkoping, Sweden.; Gerdle, B (corresponding author), Ctr Med Image Sci & Visualizat CMIV, SE-58183 Linkoping, Sweden.
EM bjorn.gerdle@liu.se
RI Ghafouri, Bijar/H-8257-2014; Leinhard, Olof/K-4228-2013; Lundberg,
   Peter/AGD-9679-2022
OI Lundberg, Peter/0000-0001-8661-2232; Forsgren,
   Mikael/0000-0003-4630-6550; Ghafouri, Bijar/0000-0002-6396-5104; Gerdle,
   Bjorn/0000-0002-4316-1264
FU Swedish Research Council [2018-02470]; Vinnova [2018-02470] Funding
   Source: Vinnova; Swedish Research Council [2018-02470] Funding Source:
   Swedish Research Council; Formas [2018-02470] Funding Source: Formas
FX Funding This research was funded by grants from the Swedish Research
   Council (grant number: 2018-02470) .
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NR 128
TC 8
Z9 8
U1 2
U2 7
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-7090
J9 J PAIN RES
JI J. Pain Res.
PY 2022
VL 15
BP 2517
EP 2535
DI 10.2147/JPR.S376590
PG 19
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 4F6VB
UT WOS:000848646800001
PM 36061487
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Luckhoff, H
   Phahladira, L
   Scheffler, F
   Asmal, L
   du Plessis, S
   Chiliza, B
   Kilian, S
   Emsley, R
AF Luckhoff, H.
   Phahladira, L.
   Scheffler, F.
   Asmal, L.
   du Plessis, S.
   Chiliza, B.
   Kilian, S.
   Emsley, R.
TI Weight gain and metabolic change as predictors of symptom improvement in
   first-episode schizophrenia spectrum disorder patients treated over 12
   months
SO SCHIZOPHRENIA RESEARCH
LA English
DT Article
DE Schizophrenia; Metabolic syndrome; Body mass index; Psychopathology;
   Disorganized symptoms; Weight gain
ID SYNDROME SCALE PANSS; NEGATIVE SYNDROME; ATYPICAL ANTIPSYCHOTICS;
   SERUM-LIPIDS; CLOZAPINE; PSYCHOPATHOLOGY; ASSOCIATION; RISK; 1ST
AB Background: Treatment-emergent weight gain is associated with antipsychotic efficacy in schizophrenia patients treated with clozapine and olanzapine. However, few studies have investigated this relationship in first-episode patients treated with other antipsychotics, in particular those with a lower obesogenic potential.
   Aim
   To investigate the relationships between weight gain and associated metabolic changes with psychopathology improvement in relation to age, sex, ethnicity, substance use, treatment duration and antipsychotic dose in first-episode schizophrenia spectrum disorder patients.
   Methods: This single site cohort study included 106 minimally treated or antipsychotic-naive patients treated with flupenthixol decanoate over 12 months. Psychopathology was evaluated using the Positive and Negative Syndrome Scale (PANSS) and BMI, fasting blood lipids and glucose were assessed at regular intervals. Linear regression models were constructed to determine the effects of socio-demographic, clinical and metabolic factors as predictors of change in total PANSS score and factor-derived domains.
   Results: BMI change scores were inversely correlated with change in PANSS total (R = -0.25; p = -0.011), positive (R = -0.23; p = 0.019), depressive anxiety (R = -021; p = 0.031) and disorganized symptoms (R = -0.32; p < 0.001). Linear regression analysis showed that increased BMI and treatment duration both predicted improvement in global psychopathology and disorganized symptoms independent of age, sex, ethnicity, substance use, co-medication with antidepressants and/or anticholinergics, as well as the dose and duration of antipsychotic exposure.
   Conclusions: Our findings suggest that the relationship between treatment-emergent weight gain and psychopathology improvement is not limited to patients treated with antipsychotics most associated with weight gain, and is not confounded by treatment duration and dose. (C) 2018 Elsevier B.V. All rights reserved.
C1 [Luckhoff, H.; Phahladira, L.; Scheffler, F.; Asmal, L.; du Plessis, S.; Kilian, S.; Emsley, R.] Stellenbosch Univ, Dept Psychiat, Stellenbosch, South Africa.
   [Chiliza, B.] Univ Kwazulu Natal, Nelson R Mandela Sch Med, Dept Psychiat, Durban, South Africa.
C3 Stellenbosch University; University of Kwazulu Natal
RP Luckhoff, H (corresponding author), Stellenbosch Univ, Dept Psychiat, Stellenbosch, South Africa.; Luckhoff, H (corresponding author), Fac Med & Hlth Sci, Dept Psychiat, ZA-7500 Cape Town, Western Cape, South Africa.
EM hilmarklausl@gmail.com
RI Chiliza, Bonga/AAD-6259-2019; Scheffler, Freda/HTR-2824-2023; du
   Plessis, Stefan/AFO-8572-2022
OI Luckhoff, Hilmar Klaus/0000-0002-1623-056X; Asmal,
   Laila/0000-0002-6923-6746; Scheffler, Freda/0000-0002-8898-8599
FU New Partnership for Africa's Development (NEPAD) grant, through the
   Department of Science and Technology, Republic of South Africa; South
   African Medical Research Council 'SHARED ROOTS' Flagship Project
   [MRC-RFA-IFSP-01-2013]; Lundbeck International
FX This study was funded by New Partnership for Africa's Development
   (NEPAD) grant, through the Department of Science and Technology,
   Republic of South Africa, the South African Medical Research Council
   'SHARED ROOTS' Flagship Project Grant no. MRC-RFA-IFSP-01-2013
   (Grantholder S Seedat) and an unrestricted grant from Lundbeck
   International.
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NR 51
TC 28
Z9 28
U1 0
U2 8
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0920-9964
EI 1573-2509
J9 SCHIZOPHR RES
JI Schizophr. Res.
PD APR
PY 2019
VL 206
BP 171
EP 176
DI 10.1016/j.schres.2018.11.031
PG 6
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA HY0NX
UT WOS:000467810100025
PM 30503765
DA 2025-06-11
ER

PT J
AU Gurpegui, M
   Martínez-Ortega, JM
   Gutiérrez-Rojas, L
   Rivero, J
   Rojas, C
   Jurado, D
AF Gurpegui, Manuel
   Maria Martinez-Ortega, Jose
   Gutierrez-Rojas, Luis
   Rivero, Juan
   Rojas, Cristina
   Jurado, Dolores
TI Overweight and obesity in patients with bipolar disorder or
   schizophrenia compared with a non-psychiatric sample
SO PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
LA English
DT Review
DE Bipolar disorder; Body mass index (BMI); Obesity; Overweight;
   Schizophrenia
ID BODY-MASS INDEX; SYNDROME SCALE PANSS; QUALITY-OF-LIFE; WEIGHT-GAIN;
   METABOLIC SYNDROME; PSYCHIATRIC-DISORDERS; ANXIETY DISORDERS;
   ASSOCIATION; HEALTH; PREVALENCE
AB Objective: Multiple studies suggest an association of overweight and obesity with bipolar disorder (BD) and schizophrenia. The goal of this paper was to determine the magnitude of this association and its relationship with previous course-of-illness and other variables of clinical interest.
   Methods: The prevalence of overweight and obesity was compared among patients with BD (n=108), patients with schizophrenia (n=250) and a non-psychiatric control group (n=290). Moreover, within each group we analyzed the variables associated with overweight [including obesity, i.e., body mass index (BMI)>= 25] and obesity (BMI >= 30) adjusting for a possible confounding effect of sex, age and educational level by logistic regression.
   Results: In comparison with the non-psychiatric sample, a strong association of both EMI >= 25 and obesity was observed with BD and schizophrenia (adjusted odds ratios between 3.4 and 4.6; P-values <0.001). Overweight was significantly associated with male sex and increasing age in both control and BD groups; and with female sex among schizophrenia patients. Moreover, for BD patients, earlier onset of first BD symptoms, presence of a non-psychiatric illness, current use of mood-stabilizing medication, and being a non-smoker were significantly associated with overweight; and male sex and the presence of a non-psychiatric illness, with obesity. Within the schizophrenia patients, obesity was significantly associated with female sex, intermediate age range and lower PANSS score.
   Conclusions: Among patients with BD or schizophrenia, the chronic course of their illness and their current treatment with psychotropic medication might be more relevant for becoming overweight or obese than the specific psychiatric illness. (c) 2012 Elsevier Inc. All rights reserved.
C1 [Gurpegui, Manuel] Univ Granada, Dept Psychiat, Fac Med, E-18071 Granada, Spain.
   [Gurpegui, Manuel; Maria Martinez-Ortega, Jose; Gutierrez-Rojas, Luis; Jurado, Dolores] Univ Granada, Ctr Biomed Res CIBM, Inst Neurosci, Res Grp CTS 549, E-18071 Granada, Spain.
   [Gutierrez-Rojas, Luis; Rojas, Cristina] San Cecilio Univ Hosp, Psychiat Serv, Granada, Spain.
   [Rivero, Juan] San Cecilio Univ Hosp, Granada Sur Zaidin Community Mental Hlth Ctr, Granada, Spain.
   [Jurado, Dolores] Univ Granada, Dept Prevent Med & Publ Hlth, E-18071 Granada, Spain.
C3 University of Granada; University of Granada; Hospital Universitario San
   Cecilio; Hospital Universitario San Cecilio; University of Granada
RP Gurpegui, M (corresponding author), Univ Granada, Dept Psychiat, Fac Med, Av Madrid 11, E-18071 Granada, Spain.
EM gurpegui@ugr.es
RI Gurpegui, Manuel/JDD-0226-2023; de Aguilar, Juan/AAL-3311-2021; Rojas,
   Luis/AAI-1110-2021
OI Gurpegui, Manuel/0000-0002-1262-1627; Gutierrez-Rojas,
   Luis/0000-0003-0082-2189
FU Institut de Salud Carlos III, Spanish Ministry of Health [FIS 06/1890]
FX The authors would like to gratefully acknowledge the collaboration of
   all participants (patients and non-patients) in this study, and the help
   of Jean L. Sanders in editing the manuscript. The preparation of this
   article involved support through a grant (FIS 06/1890) from the Institut
   de Salud Carlos III, Spanish Ministry of Health.
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NR 66
TC 60
Z9 63
U1 0
U2 22
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0278-5846
EI 1878-4216
J9 PROG NEURO-PSYCHOPH
JI Prog. Neuro-Psychopharmacol. Biol. Psychiatry
PD APR 27
PY 2012
VL 37
IS 1
BP 169
EP 175
DI 10.1016/j.pnpbp.2012.01.014
PG 7
WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA 924DW
UT WOS:000302672300025
PM 22326681
DA 2025-06-11
ER

PT J
AU Jetha, MM
   Nzekwu, U
   Lewanczuk, RZ
   Ball, GDC
AF Jetha, Mary M.
   Nzekwu, Ugo
   Lewanczuk, Richard Z.
   Ball, Geoff D. C.
TI A Novel, Non-Invasive <SUP>13</SUP>C-Glucose Breath Test to Estimate
   Insulin Resistance in Obese Prepubertal Children
SO JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
LA English
DT Article
DE pediatrics; prepubertal; obesity; insulin resistance; type 2 diabetes
   mellitus; HOMA
ID BETA-CELL FUNCTION; METABOLIC SYNDROME; MODEL ASSESSMENT; SENSITIVITY;
   SECRETION; ADOLESCENTS; GLUCOSE; OVERWEIGHT; PREVALENCE; VALIDATION
AB Insulin resistance (IR) is an important risk factor for the development of type 2 diabetes mellitus in obese boys and girls. Because needle-associated fear and anxiety are common in children, non-invasive methods to determine IR are desirable. Our objective in this cross-sectional study of obese prepubertal children (n = 39) was to compare estimates of IR using a novel, non-invasive technique (C-13-glucose breath test) with common indices of IR derived from an oral glucose tolerance test (OGTT). For the C-13-glucose breath test, samples were collected before and 90 minutes after ingestion of 25 ling C-13-labelled glucose. For the OGTT, glucose and insulin samples were collected at 0, 15, 30, 45, 60, 90 and 120 minutes. The homeostatic model assessment of insulin resistance (HOMA-IR), quantitative insulin sensitivity check index (QUICKI), insulin area-under-the-curve (AUC), and sum-of-insulin were calculated as indices of IR. Pearson correlations revealed significant, but moderate, associations between the C-13-glucose breath test and fasting insulin (r = -0.50; p <0.01), 2-hour insulin (r = -0.40; p <0.05), HOMA-IR (r = -0.51; p <0.01), QUICKI (r = 0.53; p <0.01), insulin AUC (r = -0.22; NS), and sum-of-insulin (r = -0.48; p <0.05). Paired t-tests between estimates of IR from C-13-glucose breath test and other indices showed no significant differences. Bland-Altman plots showed acceptable levels of agreement between indices of IR. In obese prepubertal children, the C-13-glucose breath test can provide a proxy estimate of IR when gold-standard techniques are either unavailable or impractical.
C1 [Jetha, Mary M.; Ball, Geoff D. C.] Univ Alberta, Dept Pediat, Fac Med & Dent, Edmonton, AB T6G 2J3, Canada.
   [Nzekwu, Ugo] Univ Alberta, Dept Agr Food & Nutr Sci, Fac Agr Life & Environm Sci, Edmonton, AB T6G 2J3, Canada.
   [Lewanczuk, Richard Z.] Univ Alberta, Dept Med, Fac Med & Dent, Edmonton, AB T6G 2J3, Canada.
C3 University of Alberta; University of Alberta; University of Alberta
RP Ball, GDC (corresponding author), Univ Alberta, Dept Pediat, Fac Med & Dent, 8213 Aberhart Ctr,11402 Univ Ave, Edmonton, AB T6G 2J3, Canada.
EM geoff.ball@ualberta.ca
FU Stollery Children's Hospital Foundation (Edmonton, AB); Isotechnika Inc.
   (Edmonton, AB); Alberta Heritage Foundation for Medical Research;
   Canadian Institutes of Health Research
FX This study was supported by a research grant from the Stollery
   Children's Hospital Foundation (Edmonton, AB). Isotechnika Inc.
   (Edmonton, AB) provided breath tests kits and performed
   <SUP>13</SUP>C-glucose analyses. The authors thank the children and
   families for their participation in this study, the staff at the
   Clinical Investigation Unit (University of Alberta Hospital) for
   assistance with OGTT administration, and Ms Christina Haines
   (Biostatistics Consulting Group, Women and Children's Health Research
   Institute, Edmonton, AB) for statistical support. GDCB is supported by a
   Population Health Investigator Award from the Alberta Heritage
   Foundation for Medical Research and a New Investigator Award from the
   Canadian Institutes of Health Research.
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NR 27
TC 16
Z9 18
U1 0
U2 6
PU WALTER DE GRUYTER GMBH
PI BERLIN
PA GENTHINER STRASSE 13, D-10785 BERLIN, GERMANY
SN 0334-018X
EI 2191-0251
J9 J PEDIATR ENDOCR MET
JI J. Pediatr. Endocrinol. Metab.
PD NOV
PY 2009
VL 22
IS 11
BP 1051
EP 1059
DI 10.1515/JPEM.2009.22.11.1051
PG 9
WC Endocrinology & Metabolism; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Pediatrics
GA 536YR
UT WOS:000273080400009
PM 20101891
DA 2025-06-11
ER

PT J
AU Bond, DJ
   Silveira, LE
   Torres, IJ
   Lam, RW
   Yatham, LN
AF Bond, David J.
   Silveira, Leonardo E.
   Torres, Ivan J.
   Lam, Raymond W.
   Yatham, Lakshmi N.
TI Weight gain as a risk factor for progressive neurochemical abnormalities
   in first episode mania patients: a longitudinal magnetic resonance
   spectroscopy study
SO PSYCHOLOGICAL MEDICINE
LA English
DT Article
DE Bipolar disorder; body mass index; glutamate; hippocampus; magnetic
   resonance spectroscopy; N-acetylaspartate
ID BODY-MASS INDEX; TREATMENT OPTIMIZATION PROGRAM; ANXIETY TREATMENTS
   CANMAT; PROSPECTIVE 12-MONTH DATA; BIPOLAR-DISORDER; CANADIAN NETWORK;
   METABOLIC SYNDROME; N-ACETYLASPARTATE; BRAIN VOLUME; OBESITY
AB Background We previously reported that bipolar disorder (BD) patients with clinically significant weight gain (CSWG; > 7% of baseline weight) in the 12 months after their first manic episode experienced greater limbic brain volume loss than patients without CSWG. It is unknown whether CSWG is also a risk factor for progressive neurochemical abnormalities. Methods We investigated whether 12-month CSWG predicted greater 12-month decreases in hippocampal N-acetylaspartate (NAA) and greater increases in glutamate + glutamine (Glx) following a first manic episode. In BD patients (n = 58) and healthy comparator subjects (HS; n = 34), we measured baseline and 12-month hippocampal NAA and Glx using bilateral 3-Tesla single-voxel proton magnetic resonance spectroscopy. We used general linear models for repeated measures to investigate whether CSWG predicted neurochemical changes. Results Thirty-three percent of patients and 18% of HS experienced CSWG. After correcting for multiple comparisons, CSWG in patients predicted a greater decrease in left hippocampal NAA (effect size = -0.52, p = 0.005). CSWG also predicted a greater decrease in left hippocampal NAA in HS with a similar effect size (-0.53). A model including patients and HS found an effect of CSWG on Delta left NAA (p = 0.007), but no diagnosis effect and no diagnosis x CSWG interaction, confirming that CSWG had similar effects in patients and HS. Conclusion CSWG is a risk factor for decreasing hippocampal NAA in BD patients and HS. These results suggest that the well-known finding of reduced NAA in BD may result from higher body mass index in patients rather than BD diagnosis.
C1 [Bond, David J.] Univ Minnesota, Dept Psychiat & Behav Sci, Med Sch, Minneapolis, MN USA.
   [Bond, David J.; Torres, Ivan J.; Lam, Raymond W.; Yatham, Lakshmi N.] Univ British Columbia, Mood Disorders Ctr, Vancouver, BC, Canada.
   [Silveira, Leonardo E.] Hosp Clin Porto Alegre, Ctr Pesquisas Expt, Lab Mol Psychiat, Porto Alegre, RS, Brazil.
   [Silveira, Leonardo E.] INCT Translat Med, Porto Alegre, RS, Brazil.
C3 University of Minnesota System; University of Minnesota Twin Cities;
   University of British Columbia; Hospital de Clinicas de Porto Alegre
RP Yatham, LN (corresponding author), Univ British Columbia, Mood Disorders Ctr, Vancouver, BC, Canada.
EM l.yatham@ubc.ca
RI ; Lam, Raymond W./D-2529-2013; Yatham, Lakshmi N/HCH-4139-2022
OI Bond, David/0000-0002-8713-7311; Lam, Raymond W./0000-0001-7142-4669;
   Torres, Ivan/0000-0001-5107-3339; Yatham, Lakshmi N/0000-0002-7405-0954
FU AstraZeneca Canada
FX The data for this manuscript were generated from the Systematic
   Treatment Optimization Program for Early Mania (STOP-EM), which was
   supported by an unrestricted grant to LNY from AstraZeneca Canada. The
   sponsor had no input into the design or conduct of the study;
   collection, management, analysis, or interpretation of the data;
   preparation, review, or approval of the manuscript; or decision to
   submit the manuscript for publication.
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NR 60
TC 1
Z9 1
U1 1
U2 7
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0033-2917
EI 1469-8978
J9 PSYCHOL MED
JI Psychol. Med.
PD DEC
PY 2022
VL 52
IS 16
BP 3783
EP 3791
AR PII S0033291721000544
DI 10.1017/S0033291721000544
EA MAR 2021
PG 9
WC Psychology, Clinical; Psychiatry; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA G0SX0
UT WOS:000785725300001
PM 33706825
DA 2025-06-11
ER

PT J
AU Viscogliosi, G
   Donfrancesco, C
   Lo Noce, C
   Giampaoli, S
   Vanuzzo, D
   Carle, F
   Palmieri, L
AF Viscogliosi, Giovanni
   Donfrancesco, Chiara
   Lo Noce, Cinzia
   Giampaoli, Simona
   Vanuzzo, Diego
   Carle, Flavia
   Palmieri, Luigi
TI Association Between Antidepressant Medication Use and Prevalence and
   Control of Cardiovascular Risk Factors in Community-Dwelling Older
   Adults: The Italian Health Examination Survey 2008-2012
SO METABOLIC SYNDROME AND RELATED DISORDERS
LA English
DT Article
DE antidepressants; cardiovascular risk factors; older adults; population
ID MAJOR DEPRESSIVE DISORDER; METABOLIC SYNDROME; MYOCARDIAL-INFARCTION;
   MORTALITY; ANXIETY; OBESITY
AB Background: To assess the association of antidepressant (AD) medication use with prevalence and control of cardiovascular (CV) risk factors.
   Methods: Data of older adults from the population-based Italian Osservatorio Epidemiologico Cardiovascolare/Health Examination Survey (OEC/HES) Study 2008-2012 were used. CV risk factors were measured using standardized procedures. Information on clinical features, lifestyles, and medications was collected using standardized questionnaires. Logistic regression models were elaborated to assess associations between AD use and prevalence and control of CV risk factors.
   Results: Around 2549 participants (age 71.4 +/- 4.2 years, 51.3% men) were studied; 268 (10.5%) were AD users. Of these, 72.4% used selective serotonin reuptake inhibitors (SSRI). AD users had less favorable CV risk factor profile and were less likely to achieve control of blood pressure and total cholesterol. After multiple adjustment for potentially confounding variables, AD use was associated with greater likelihood of having diabetes (OR = 1.05, 95% CI = 1.02-1.10, P = 0.008), hypertension (OR = 1.10, 95% CI = 1.05-1.20, P = 0.003), and hypercholesterolemia (OR = 1.08, 95% CI = 1.04-1.14, P < 0.001). Among participants treated for hypertension and hypercholesterolemia, AD use was associated with poorer control of BP (OR = 1.07, 95% CI = 1.03-1.12, P = 0.001) and cholesterol (OR = 1.06, 95% CI = 1.01-1.12, P = 0.021). Results persisted virtually unchanged when analyses were restricted to participants on SSRI.
   Conclusions: AD use was associated with greater prevalence and poorer control of traditional risk factors for CV disease in a population-based sample of older adults. Such results highlight the need for surveillance of CV risk factors and promotion of healthy lifestyles in older adults with psychopathology and, in particular, in those under AD treatment.
C1 [Viscogliosi, Giovanni; Donfrancesco, Chiara; Lo Noce, Cinzia; Giampaoli, Simona; Palmieri, Luigi] Natl Inst Hlth, Dept Cardiovasc Dysmetab & Aging Associated Dis, Via Giano Della Bella 34, I-00162 Rome, Italy.
   [Viscogliosi, Giovanni; Carle, Flavia] Polytech Univ Marche, Ctr Epidemiol & Biostat, Ancona, Italy.
   [Vanuzzo, Diego] Natl Assoc Hosp Cardiologists, Florence, Italy.
C3 Istituto Superiore di Sanita (ISS); Marche Polytechnic University
RP Viscogliosi, G (corresponding author), Natl Inst Hlth, Dept Cardiovasc Dysmetab & Aging Associated Dis, Via Giano Della Bella 34, I-00162 Rome, Italy.
EM giovanni.viscogliosi@libero.it
RI donfrancesco, chiara/K-1460-2016
OI donfrancesco, chiara/0000-0002-8040-5571
CR Alamo C, 2014, PSYCHOGERIATRICS, V14, P261, DOI 10.1111/psyg.12057
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NR 24
TC 4
Z9 4
U1 0
U2 2
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-4196
EI 1557-8518
J9 METAB SYNDR RELAT D
JI Metab. Syndr. Relat. Disord.
PD MAR 1
PY 2020
VL 18
IS 2
BP 73
EP 78
DI 10.1089/met.2019.0088
PG 6
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Research & Experimental Medicine
GA KS3MG
UT WOS:000518214900001
PM 31821103
DA 2025-06-11
ER

PT J
AU Wu, M
   Villano, A
   Russo, G
   Di Franco, A
   Stazi, A
   Lauria, C
   Sestito, A
   Lanza, GA
   Crea, F
AF Wu, Monica
   Villano, Angelo
   Russo, Giulio
   Di Franco, Antonino
   Stazi, Alessandra
   Lauria, Christian
   Sestito, Alfonso
   Lanza, Gaetano A.
   Crea, Filippo
TI Poor Tolerance and Limited Effects of Isosorbide-5-Mononitrate in
   Microvascular Angina
SO CARDIOLOGY
LA English
DT Article
DE Microvascular angina; Isosorbide-5-mononitrate; Quality of life;
   Exercise stress test
ID DESCENDING CORONARY-ARTERY; FLOW RESERVE; CHEST-PAIN; SYNDROME-X;
   SENSITIVITY
AB Objectives: To assess the effects of isosorbide-5-mononitrate (ISMN) in patients with microvascular angina (MVA). Methods: We randomized 20 MVA patients, treated with a beta-blocker or a calcium antagonist, to 60 mg slow-release ISMN (halved to 30 mg if not tolerated) or placebo once a day for 4 weeks; the patients were then switched to the other treatment for another 4 weeks. Their clinical status was assessed with the Seattle Angina Questionnaire (SAQ) and the EuroQoL score for quality of life. The exercise stress test (EST), coronary blood flow (CBF) response to nitrate and the cold pressor test (CPT), brachial artery flow-mediated dilation (FMD) and nitrate-mediated dilation (NMD) were also assessed. Results: Nine patients (45%) did not complete the ISMN phase due to side effects; 2 patients refused a follow-up. Nine patients completed the study. The SAQ and EuroQoL scores were significantly better with ISMN than with placebo, although the differences were small. No differences were found between the treatments in the EST results, CBF response to nitroglycerin (p = 0.55) and the CPT (p = 0.54), FMD (p = 0.26) and NMD (p = 0.35). Conclusions: In this study, a high proportion of MVA patients showed an intolerance to ISMN; in those tolerating the drug, significant effects on their angina status were observed, but the benefit appeared to be modest and independent of effects on coronary microvascular function. (C) 2015 S. Karger AG, Basel
C1 [Wu, Monica; Villano, Angelo; Russo, Giulio; Di Franco, Antonino; Stazi, Alessandra; Lauria, Christian; Sestito, Alfonso; Lanza, Gaetano A.; Crea, Filippo] Univ Cattolica Sacro Cuore, Dept Cardiovasc Sci, IT-00168 Rome, Italy.
C3 Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli
RP Lanza, GA (corresponding author), Univ Cattolica Sacro Cuore, Ist Cardiol, Largo A Gemelli 8, IT-00168 Rome, Italy.
EM g.a.lanza@rm.unicatt.it
RI Russo, Giulio/AAB-3944-2019; Crea, Filippo/AAC-9754-2022; Villano,
   Angelo/AAC-7245-2022; Lanza, Gaetano/AAC-2660-2019
OI Villano, Angelo/0000-0003-1651-1369; Lanza, Gaetano
   Antonio/0000-0003-2187-6653; Russo, Giulio/0000-0002-6302-0135
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NR 20
TC 20
Z9 20
U1 0
U2 5
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0008-6312
EI 1421-9751
J9 CARDIOLOGY
JI Cardiology
PY 2015
VL 130
IS 4
BP 201
EP 206
DI 10.1159/000370027
PG 6
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA CF1AJ
UT WOS:000352275600001
PM 25790943
DA 2025-06-11
ER

PT J
AU Greco, D
   Gambina, F
   Maggio, F
AF Greco, Domenico
   Gambina, Francesco
   Maggio, Filippo
TI Ophthalmoplegia in diabetes mellitus: a retrospective study
SO ACTA DIABETOLOGICA
LA English
DT Article
DE Cranial neuropathies; Diabetes mellitus; Ophthalmoplegia
ID CRANIAL NERVE-III; OCULOMOTOR; MONONEUROPATHY; PALSIES; PARALYSIS;
   PROGNOSIS; TROCHLEAR; IV; VI
AB Ophthalmoplegia, despite being a rare entity in diabetes mellitus, is associated with great anxiety for the patients and often appears to be a serious problem from a diagnostic and therapeutic point of view. There have been few studies primarily concerned with the relative frequencies and clinical characteristics of oculomotor neuropathies in diabetic subjects. Those published have emanated largely from neurological and/or ophthalmological referral centres rather than metabolic departments. Objective of this study was to determine the incidence, the clinical characteristics and risk factors for developing ophthalmoplegia among persons with diabetes mellitus. We have performed a retrospective study of all diabetic patients with ophthalmoplegia who were seen in the Metabolic Division at "S. Biagio" Hospital, Marsala, over the 10 year period from 1998 to 2007. A detailed history and blood laboratory profile were obtained for each patient. During the period of the survey a total of 6,765 diabetic subjects were hospitalised and ophthalmoplegia was identified in 27 patients (0.40%). Isolated III nerve palsies accounted for the majority of patients (59.3%), with VI nerve palsies (29.6%) occurring more frequently than multiple palsies (11.1%). These patients had a marked comorbidity and were found to have a poorly controlled diabetes. The patients with VI nerve palsies showed a tendency toward a higher coexistence of diabetic retinopathy and cardiovascular risk factors than those with III cranial nerve palsies. Ophthalmoplegia is a serious and not common problem among patients with diabetes mellitus; the oculomotor nerve was most frequently affected in our case-report. The fact that the coexistence of diabetic complications and cardiovascular risk factors was slightly higher in patients with VI nerve palsy is compatible with the hypothesis that this ischemic event might be more closely related to diabetes and metabolic syndrome in its pathogenesis.
C1 [Greco, Domenico; Gambina, Francesco; Maggio, Filippo] S Biagio Hosp, Div Diabetol, Marsala, TP, Italy.
RP Greco, D (corresponding author), Via Cosenza 155, I-91016 Erice, TP, Italy.
EM drgreco@alice.it
OI Greco, Domenico/0009-0002-7511-4910
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NR 19
TC 41
Z9 46
U1 0
U2 6
PU SPRINGER-VERLAG ITALIA SRL
PI MILAN
PA VIA DECEMBRIO, 28, MILAN, 20137, ITALY
SN 0940-5429
EI 1432-5233
J9 ACTA DIABETOL
JI Acta Diabetol.
PD MAR
PY 2009
VL 46
IS 1
BP 23
EP 26
DI 10.1007/s00592-008-0053-8
PG 4
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 402GA
UT WOS:000263001000003
PM 18758685
DA 2025-06-11
ER

PT J
AU Zeinali-Nezhad, N
   Najafipour, H
   Shadkam, M
   Pourhamidi, R
AF Zeinali-Nezhad, Nazanin
   Najafipour, Hamid
   Shadkam, Mitra
   Pourhamidi, Rashed
TI Prevalence and trend of multiple coronary artery disease risk factors
   and their 5-year incidence rate among adult population of Kerman:
   results from KERCADR study
SO BMC PUBLIC HEALTH
LA English
DT Article
DE Coronary artery disease; Prevalence; Incidence rate; Multiple risk
   factors; KERCADR study
ID CARDIOVASCULAR-DISEASE; PHYSICAL-ACTIVITY; URBAN-POPULATION; OBESITY;
   IRAN; ASSOCIATION; PREVENTION; OVERWEIGHT; SOUTHEAST; SMOKING
AB BackgroundCoronary artery diseases (CADs) are the most important non-communicable diseases (NCDs), which cause the highest number of deaths around the world. Hypertension (HTN), dyslipidemia (DL), diabetes mellitus (DM), obesity (OB), low physical activity (LPA), smoking, opium consumption (OC) and anxiety are the most important CAD risk factors, which are more dangerously present in combination in some patients.MethodsA total of 5835 people aged 15 to 75 years were enrolled in the phase 1 (2012) and followed up to the phase 2 (2017) of the population-based Kerman coronary artery diseases risk factors study (KERCADRS). The prevalence and pattern of different combinations of CAD risk factors (double to quintuple) and their 5-year incidence rates were assessed.ResultsThe prevalence of single CAD risk factors (RFs) in phase 2 was 50.2% (DL), 47.1% (LPA), 28.1% (abdominal obesity), 21.2% (OB), 16.5% (HTN), 9.2% (smoking), 9.1% (OC), and 8.4% (DM). The most frequent combination of risk factors was LPA plus DL (23.9%), metabolic syndrome (19.6%), and DL plus OB (17.8%). The 5-year incidence rates of multiple comorbidities (in persons per 100 person-years) was DL plus LPA (2.80%), HTN plus DL (1.53%), and abdominal obesity (AOB) plus DL (1.47%). The most participants (84.4%) suffered from at least one RF, while 54.9% had at least two and 29.9% had at least three RFs.ConclusionThe results showed that a large portion of the study population suffers from multiple CAD RFs. The findings underscore the importance of identifying multiple CAD risk factors to reduce the overall burden of these NCDs.
C1 [Zeinali-Nezhad, Nazanin] Kerman Univ Med Sci, Inst Neuropharmacol, Physiol Res Ctr, Kerman, Iran.
   [Najafipour, Hamid] Kerman Univ Med Sci, Inst Basic & Clin Physiol Sci, Cardiovasc Res Ctr, Kerman, Iran.
   [Shadkam, Mitra] Kerman Univ Med Sci, Inst Basic & Clin Physiol Sci, Endocrinol & Metab Res Ctr, Kerman, Iran.
   [Pourhamidi, Rashed] Bam Univ Med Sci, Non Communicable Dis Res Ctr, Bam, Iran.
   [Najafipour, Hamid] Kerman Univ Med Sci, Afzalipour Med Fac, Dept Physiol, Kerman, Iran.
   [Najafipour, Hamid] Kerman Univ Med Sci, Afzalipour Med Fac, Cardiovasc Res Ctr, Kerman, Iran.
C3 Kerman University of Medical Sciences; Kerman University of Medical
   Sciences; Kerman University of Medical Sciences; Kerman University of
   Medical Sciences; Kerman University of Medical Sciences
RP Najafipour, H (corresponding author), Kerman Univ Med Sci, Inst Basic & Clin Physiol Sci, Cardiovasc Res Ctr, Kerman, Iran.; Najafipour, H (corresponding author), Kerman Univ Med Sci, Afzalipour Med Fac, Dept Physiol, Kerman, Iran.; Najafipour, H (corresponding author), Kerman Univ Med Sci, Afzalipour Med Fac, Cardiovasc Res Ctr, Kerman, Iran.
EM najafipourh@yahoo.co.uk
RI Najafipour, Hamid/U-7922-2017; pourhamidi, rashed/HJZ-0546-2023
OI Zeinali Nezhad, Nazanin/0009-0007-9159-3487; pourhamidi,
   rashed/0000-0002-2635-7644; Najafipour, Hamid/0000-0002-8030-8704
FU Deputy of Research and Technology at Kerman University of Medical
   Sciences [KMU.REC.1393/310]
FX The Deputy of Research and Technology at Kerman University of Medical
   Sciences funded the study (grant No KMU.REC.1393/310).
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NR 49
TC 1
Z9 1
U1 0
U2 0
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2458
J9 BMC PUBLIC HEALTH
JI BMC Public Health
PD JAN 2
PY 2024
VL 24
IS 1
AR 25
DI 10.1186/s12889-023-17504-8
PG 12
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA DX5J7
UT WOS:001135394000032
PM 38166891
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Brunner, EJ
   Shipley, MJ
   Ahmadi-Abhari, S
   Hernandez, CV
   Abell, JG
   Singh-Manoux, A
   Kawachi, I
   Kivimaki, M
AF Brunner, Eric J.
   Shipley, Martin J.
   Ahmadi-Abhari, Sara
   Hernandez, Carlos Valencia
   Abell, Jessica G.
   Singh-Manoux, Archana
   Kawachi, Ichiro
   Kivimaki, Mika
TI Midlife contributors to socioeconomic differences in frailty during
   later life: a prospective cohort study
SO LANCET PUBLIC HEALTH
LA English
DT Article
ID OLDER-ADULTS; WHITEHALL-II; RISK-FACTORS; BRITISH MEN; HEALTH;
   DISABILITY; PROFILE; PEOPLE; CIRCUMSTANCES; TRAJECTORIES
AB Background Health inequalities persist into old age. We aimed to investigate risk factors for socioeconomic differences in frailty that could potentially be modified through policy measures.
   Methods In this multi-wave longitudinal cohort study (Whitehall II study), we assessed participants' socioeconomic status, behavioural and biomedical risk factors, and disease status at age 45-55 years, and frailty (defined according to the Fried phenotype) at baseline and at one or more of three clinic visits about 18 years later (mean age 69 years [SD 5.9]). We used logistic mixed models to examine the associations between socioeconomic status and risk factors at age 50 years and subsequent prevalence of frailty (adjusted for sex, ethnic origin, and age), with sensitivity analyses and multiple imputation for missing data.
   Findings Between Sept 9, 2007, and Dec 8, 2016, 6233 middle-aged adults were measured for frailty. Frailty was present in 562 (3%) of 16 164 person-observations, and varied by socioeconomic status: 145 (2%) person-observations had high socioeconomic status, 241 (4%) had intermediate status, and 176 (7%) had low socioeconomic status, adjusting for sex and age. Risk factors for frailty included cardiovascular disease, depression, smoking, high or abstinent alcohol consumption, low fruit and vegetable consumption, physical inactivity, poor lung function, hypertension, and overweight or obesity. Cardiometabolic markers for future frailty were high ratio of total to high-density lipoprotein cholesterol, and raised interleukin-6 and C-reactive protein concentrations. The five most important factors contributing to the frailty gradient, assessed by percent attenuation of the association between socioeconomic status and frailty, were physical activity (13%), interleukin-6 (13%), body-mass index category (11%), C-reactive protein (11%), and poor lung function (10%). Overall, socioeconomic differences in frailty were reduced by 40% in the maximally-adjusted model compared with the minimally-adjusted model.
   Interpretation Behavioural and cardiometabolic risk factors in midlife account for more than a third of socioeconomic differences in frailty. Our findings suggest that interventions targeting physical activity, obesity, smoking, and low-grade inflammation in middle age might reduce socioeconomic differences in later-life frailty. Copyright (c) 2018 The Author(s). Published by Elsevier Ltd.
C1 [Brunner, Eric J.; Shipley, Martin J.; Ahmadi-Abhari, Sara; Hernandez, Carlos Valencia; Abell, Jessica G.; Singh-Manoux, Archana] UCL, Res Dept Epidemiol & Publ Hlth, London, England.
   [Singh-Manoux, Archana] Hop Paul Brousse, Ctr Res Epidemiol & Publ Hlth, INSERM, Villejuif, France.
   [Kawachi, Ichiro] Harvard Sch Publ Hlth, Dept Social & Behav Sci, Boston, MA USA.
   [Kivimaki, Mika] Univ Helsinki, Clinicum, Fac Med, Helsinki, Finland.
C3 University of London; University College London; Assistance Publique
   Hopitaux Paris (APHP); Hopital Universitaire Paul-Brousse - APHP;
   Institut National de la Sante et de la Recherche Medicale (Inserm);
   Harvard University; Harvard T.H. Chan School of Public Health;
   University of Helsinki
RP Brunner, EJ (corresponding author), UCL, Dept Epidemiol & Publ Hlth, London WC1E 6BT, England.
EM e.brunner@ucl.ac.uk
RI Kawachi, Ichiro/A-8329-2009; Brunner, Eric/H-2114-2011; Kivimaki,
   Mika/B-3607-2012; Ahmadi-Abhari, Sara/MSZ-0567-2025; Singh-Manoux,
   Archana/F-6804-2013
OI Singh-Manoux, Archana/0000-0002-1244-5037; Brunner,
   Eric/0000-0002-0595-4474; Ahmadi-Abhari, Sara/0000-0003-4440-4050;
   Kivimaki, Mika/0000-0002-4699-5627
FU British Heart Foundation; British Medical Research Council; MRC
   [MR/R024227/1, MR/K013351/1] Funding Source: UKRI
FX British Heart Foundation and British Medical Research Council.
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NR 41
TC 66
Z9 67
U1 0
U2 33
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 2468-2667
J9 LANCET PUBLIC HEALTH
JI Lancet Public Health
PD JUL
PY 2018
VL 3
IS 7
BP E313
EP E322
DI 10.1016/S2468-2667(18)30079-3
PG 10
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA GL5QE
UT WOS:000437222600007
PM 29908857
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Romo-Nava, F
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   Colby, CL
   Prieto, ML
   Veldic, M
   Singh, B
   Gardea-Resendez, M
   Nunez, NA
   Ozerdem, A
   Biernacka, JM
   Frye, MA
   McElroy, SL
AF Romo-Nava, Francisco
   Blom, Thomas
   Cuellar-Barboza, Alfredo B.
   Awosika, Oluwole O.
   Martens, Brian E.
   Mori, Nicole N.
   Colby, Colin L.
   Prieto, Miguel L.
   Veldic, Marin
   Singh, Balwinder
   Gardea-Resendez, Manuel
   Nunez, Nicolas A.
   Ozerdem, Aysegul
   Biernacka, Joanna M.
   Frye, Mark A.
   McElroy, Susan L.
TI Revisiting the bipolar disorder with migraine phenotype: Clinical
   features and comorbidity
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
ID GENERAL MEDICAL CONDITIONS; METABOLIC SYNDROME; DIAGNOSTIC SCALE;
   EATING-DISORDERS; PREVALENCE; POPULATION; HEADACHE; METAANALYSIS;
   SCHIZOPHRENIA; PARTICIPANTS
AB Introduction: To evaluate the prevalence and clinical correlates of lifetime migraine among patients with bipolar disorder (BD).
   Methods: In a cross-sectional study, we evaluated 721 adults with BD from the Mayo Clinic Bipolar Disorder Biobank and compared clinical correlates of those with and without a lifetime history of migraine. A structured clinical interview (DSM-IV) and a clinician-assessed questionnaire were utilized to establish a BD diagnosis, lifetime history of migraine, and clinical correlates.
   Results: Two hundred and seven (29%) BD patients had a lifetime history of migraine. BD patients with migraine were younger and more likely to be female as compared to those without migraine (p values <0.01). In a multivariate logistic regression model, younger age (OR=0.98, p<0.01), female sex (OR=2.02, p<0.01), higher shape/weight concern (OR=1.04, p=0.02), greater anxiety disorder comorbidities (OR=1.24, p<0.01), and evening chronotype (OR=1.65, p=0.03) were associated with migraine. In separate regression models for each general medical comorbidity (controlled for age, sex, and site), migraines were significantly associated with fibromyalgia (OR=3.17, p<0.01), psoriasis (OR=2.65, p=0.03), and asthma (OR=2.0, p<0.01). Participants with migraine were receiving ADHD medication (OR=1.53, p=0.05) or compounds associated with weight loss (OR=1.53, p=0.02) at higher rates compared to those without migraine.
   Limitations: Study design precludes determination of causality. Migraine subtypes and features were not assessed.
   Conclusions: Migraine prevalence is high in BD and is associated with a more severe clinical burden that includes increased comorbidity with pain and inflammatory conditions. Further study of the BD-migraine phenotype may provide insight into common underlying neurobiological mechanisms.
C1 [Romo-Nava, Francisco; Blom, Thomas; Martens, Brian E.; Mori, Nicole N.; McElroy, Susan L.] Lindner Ctr HOPE, Mason, OH USA.
   [Romo-Nava, Francisco; Blom, Thomas; Martens, Brian E.; Mori, Nicole N.; McElroy, Susan L.] Univ Cincinnati, Coll Med, Dept Psychiat & Behav Neurosci, Cincinnati, OH USA.
   [Cuellar-Barboza, Alfredo B.; Gardea-Resendez, Manuel] Univ Autonoma Nuevo Leon, Dept Psychiat, Monterrey, Mexico.
   [Cuellar-Barboza, Alfredo B.; Prieto, Miguel L.; Veldic, Marin; Singh, Balwinder; Gardea-Resendez, Manuel; Nunez, Nicolas A.; Ozerdem, Aysegul; Biernacka, Joanna M.; Frye, Mark A.] Mayo Clin, Dept Psychiat & Psychol, Rochester, MN USA.
   [Awosika, Oluwole O.] Univ Cincinnati, Coll Med, Dept Neurol & Rehabil Med, Cincinnati, OH USA.
   [Colby, Colin L.; Biernacka, Joanna M.] Mayo Clin, Dept Hlth Sci Res, Rochester, MN USA.
   [Prieto, Miguel L.] Univ los Andes, Fac Med, Dept Psychiat, Santiago, Chile.
   [Prieto, Miguel L.] Clin Univ los Andes, Mental Hlth Serv, Santiago, Chile.
   [Prieto, Miguel L.] Univ los Andes, Ctr Biomed Res & Innovat, Santiago, Chile.
C3 University System of Ohio; University of Cincinnati; Universidad
   Autonoma de Nuevo Leon; Mayo Clinic; University System of Ohio;
   University of Cincinnati; Mayo Clinic; Universidad de los Andes - Chile;
   Clinica Los Andes; Universidad de los Andes - Chile
RP Romo-Nava, F (corresponding author), Univ Cincinnati, Coll Med, Dept Psychiat & Behav Neurosci, Lindner Ctr HOPE Res Inst, 4075 Old Western Row Rd, Mason, OH 45040 USA.
EM romofo@ucmail.uc.edu
RI Singh, Balwinder/H-2016-2011; Cuellar-Barboza, Alfredo/A-9278-2015;
   Gardea Resendez, Manuel/LZE-8888-2025; Nunez, Nicolas/HPD-4606-2023;
   Veldic, Marin/N-7705-2017; Singh, Balwinder/M-9603-2014
OI Romo-Nava, Francisco/0000-0002-5894-3701; OZERDEM,
   AYSEGUL/0000-0002-9455-5896; Singh, Balwinder/0000-0001-7062-8192;
   Gardea Resendez, Manuel/0000-0002-9825-8792
FU Marriott Foundation
FX This study was supported by the Marriott Foundation. The Marriott
   Foundation had no role in the design and conduct of the study;
   collection, management, analysis, and interpretation of the data;
   preparation, review, or approval of the manuscript; and decision to
   submit the manuscript for publication. Partial information and results
   of this study were presented as an abstract and poster at the
   International Society of Bipolar Disorder meeting in May, 2021.
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NR 74
TC 5
Z9 5
U1 1
U2 1
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD DEC 1
PY 2021
VL 295
BP 156
EP 162
DI 10.1016/j.jad.2021.08.026
EA AUG 2021
PG 7
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA YE7XT
UT WOS:000741334700022
PM 34464877
DA 2025-06-11
ER

PT J
AU Isomura, K
   Brander, G
   Chang, Z
   Kuja-Halkola, R
   Rück, C
   Hellner, C
   Lichtenstein, P
   Larsson, H
   Mataix-Cols, D
   Fernandez de la Cruz, L
AF Isomura, Kayoko
   Brander, Gustaf
   Chang, Zheng
   Kuja-Halkola, Ralf
   Ruck, Christian
   Hellner, Clara
   Lichtenstein, Paul
   Larsson, Henrik
   Mataix-Cols, David
   Fernandez de la Cruz, Lorena
TI Metabolic and Cardiovascular Complications in Obsessive-Compulsive
   Disorder: A Total Population, Sibling Comparison Study With Long-Term
   Follow-up
SO BIOLOGICAL PSYCHIATRY
LA English
DT Article
DE Antidepressants; Antipsychotics; Cardiovascular complications; Metabolic
   syndrome; Neuroleptics; Serotonin reuptake inhibitors
ID MAJOR DEPRESSIVE DISORDER; ANTIDEPRESSANT USE; BIPOLAR DISORDER;
   METAANALYSIS; MORTALITY; ANXIETY; COHORT; RISK; SCHIZOPHRENIA;
   ABNORMALITIES
AB BACKGROUND: Obsessive-compulsive disorder (OCD) is associated with increased mortality, but the causes of this increase are poorly understood. This study examined whether OCD is associated with an increased risk of metabolic and cardiovascular complications.
   METHODS: Individuals diagnosed with OCD (n = 25,415) were identified from a cohort of 12,497,002 individuals living in Sweden between 1973 and 2013. Cox proportional hazard regression analyses were used to investigate the risk of metabolic and cardiovascular complications in OCD patients compared with the general population and unaffected full siblings of OCD individuals. Exploratory analyses were used to examine the effect of treatment with serotonin reuptake inhibitors, with or without antipsychotics, on the outcomes of interest.
   RESULTS: Individuals with OCD had a higher risk of any metabolic or cardiovascular complications compared with the general population (adjusted hazard ratio = 1.45; 95% confidence interval = 1.42-1.49) and their unaffected full siblings (adjusted hazard ratio = 1.47; 95% confidence interval = 1.40-1.54). In the fully adjusted sibling comparison models, patients had higher risks of obesity, type 2 diabetes mellitus, and circulatory system diseases. The risks were already evident from the beginning of the follow-up period and remained largely unchanged when excluding different groups of psychiatric comorbidities. Compared with patients who were not taking serotonin reuptake inhibitors, patients taking higher doses of serotonin reuptake inhibitors and who had a longer duration of treatment had significantly lower risks of metabolic and cardiovascular complications, regardless of whether they were also taking antipsychotics.
   CONCLUSIONS: OCD is associated with an increased risk of metabolic and cardiovascular complications. Our results underscore the importance of carefully monitoring metabolic and cardiovascular health in patients with OCD early in the course of the disorder.
C1 [Isomura, Kayoko; Brander, Gustaf; Ruck, Christian; Hellner, Clara; Mataix-Cols, David; Fernandez de la Cruz, Lorena] Karolinska Inst, Ctr Psychiat Res, Dept Clin Neurosci, Stockholm, Sweden.
   [Chang, Zheng; Kuja-Halkola, Ralf; Lichtenstein, Paul; Larsson, Henrik] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.
   [Isomura, Kayoko; Ruck, Christian; Hellner, Clara; Mataix-Cols, David] Stockholm Cty Council, Stockholm Hlth Care Serv, Stockholm, Sweden.
   [Larsson, Henrik] Orebro Univ, Sch Med Sci, Orebro, Sweden.
C3 Karolinska Institutet; Karolinska Institutet; Region Stockholm; Orebro
   University
RP Mataix-Cols, D (corresponding author), Karolinska Inst, Dept Clin Neurosci, Gavlegatan 22 Entre B,Floor 8, SE-11330 Stockholm, Sweden.
EM david.mataix.cols@ki.se
RI Kuja-Halkola, Ralf/ABA-5061-2020; Hellner, Clara/KUD-5305-2024; de la
   Cruz, Lorena/M-9923-2019; Mataix-Cols, David/G-3843-2010; Chang,
   Zheng/LBH-0831-2024; Rück, Christian/J-4396-2012; Larsson,
   Henrik/GYD-5161-2022
OI Larsson, Henrik/0000-0002-6851-3297; Kuja-Halkola,
   Ralf/0000-0002-3765-2067; Hellner, Clara/0000-0002-8375-9447; Fernandez
   de la Cruz, Lorena/0000-0002-1571-5485
FU Swedish Research Council for Health, Working Life and Welfare Junior
   Researcher Grant [2015-00569]; Karolinska Institutet; Swedish Research
   Council [K2013-61P-22168, 2016-01989]; Swedish Research Council for
   Health, Working Life and Welfare [2012-1678]; research foundation of
   Svenska Spel (the state-owned gambling company in Sweden); Shire
FX This work was supported by Swedish Research Council for Health, Working
   Life and Welfare Junior Researcher Grant No. 2015-00569 (to LFC), a
   Karolinska Institutet PhD stipend (to GB), Swedish Research Council
   Grant No. K2013-61P-22168 (to CR), and by Swedish Research Council for
   Health, Working Life and Welfare Grant No. 2012-1678 and the Swedish
   Research Council Grant No. 2016-01989 (to PL).r DM-C and LFC receive
   royalties for contributing articles to UpToDate, published by Wolters
   Kluwer Health. CH has served as a speaker for Shire and has received a
   grant from the research foundation of Svenska Spel (the state-owned
   gambling company in Sweden). PL has served as a speaker for Medice. HL
   has served as a speaker for Eli Lilly and Shire and has received
   research grants from Shire. The other authors report no biomedical
   financial interests or potential conflicts of interest.
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NR 41
TC 59
Z9 66
U1 0
U2 10
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
EI 1873-2402
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD SEP 1
PY 2018
VL 84
IS 5
BP 324
EP 331
DI 10.1016/j.biopsych.2017.12.003
PG 8
WC Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA GQ1UT
UT WOS:000441427200007
PM 29395042
OA hybrid
DA 2025-06-11
ER

PT J
AU Rahman, SA
   Adjeroh, D
AF Rahman, Syed Ashiqur
   Adjeroh, Donald
TI Surface-Based Body Shape Index and Its Relationship with All-Cause
   Mortality
SO PLOS ONE
LA English
DT Article
ID TO-HEIGHT RATIO; MASS INDEX; WAIST CIRCUMFERENCE; FAT DISTRIBUTION;
   CARDIOMETABOLIC RISK; CARDIOVASCULAR RISK; CENTRAL OBESITY; SCREENING
   TOOL; WEIGHT-GAIN; MEN
AB Background
   Obesity is a global public health challenge. In the US, for instance, obesity prevalence remains high at more than one-third of the adult population, while over two-thirds are obese or overweight. Obesity is associated with various health problems, such as diabetes, cardiovascular diseases (CVDs), depression, some forms of cancer, sleep apnea, osteoarthritis, among others. The body mass index (BMI) is one of the best known measures of obesity. The BMI, however, has serious limitations, for instance, its inability to capture the distribution of lean mass and adipose tissue, which is a better predictor of diabetes and CVDs, and its curved ("U-shaped") relationship with mortality hazard. Other anthropometric measures and their relation to obesity have been studied, each with its advantages and limitations. In this work, we introduce a new anthropometric measure (called Surface-based Body Shape Index, SBSI) that accounts for both body shape and body size, and evaluate its performance as a predictor of all-cause mortality.
   Methods and Findings
   We analyzed data on 11,808 subjects (ages 18-85), from the National Health and Human Nutrition Examination Survey (NHANES) 1999-2004, with 8-year mortality follow up. Based on the analysis, we introduce a new body shape index constructed from four important anthropometric determinants of body shape and body size: body surface area (BSA), vertical trunk circumference (VTC), height (H) and waist circumference (WC). The surface-based body shape index (SBSI) is defined as follows:
   SBSI = (H-7/4) (WC5/6)/BSA VTC (1)
   SBSI has negative correlation with BMI and weight respectively, no correlation with WC, and shows a generally linear relationship with age. Results on mortality hazard prediction using both the Cox proportionality model, and Kaplan-Meier curves each show that SBSI outperforms currently popular body shape indices (e.g., BMI, WC, waist-to-height ratio (WHtR), waist-to-hip ratio (WHR), A Body Shape Index (ABSI)) in predicting all-cause mortality.
   Conclusions
   We combine measures of both body shape and body size to construct a novel anthropometric measure, the surface-based body shape index (SBSI). SBSI is generally linear with age, and increases with increasing mortality, when compared with other popular anthropometric indices of body shape.
C1 [Rahman, Syed Ashiqur; Adjeroh, Donald] W Virginia Univ, Lane Dept Comp Sci & Elect Engn, Morgantown, WV 26506 USA.
C3 West Virginia University
RP Rahman, SA (corresponding author), W Virginia Univ, Lane Dept Comp Sci & Elect Engn, Morgantown, WV 26506 USA.
EM srahman2@mix.wvu.edu; don@csee.wvu.edu
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NR 62
TC 33
Z9 34
U1 3
U2 67
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD DEC 28
PY 2015
VL 10
IS 12
AR e0144639
DI 10.1371/journal.pone.0144639
PG 21
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA CZ9XO
UT WOS:000367451400008
PM 26709925
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Farzan, SF
   Chen, Y
   Trachtman, H
   Trasande, L
AF Farzan, Shohreh F.
   Chen, Yu
   Trachtman, Howard
   Trasande, Leonardo
TI Urinary polycyclic aromatic hydrocarbons and measures of oxidative
   stress, inflammation and renal function in adolescents: NHANES 2003-2008
SO ENVIRONMENTAL RESEARCH
LA English
DT Article
DE Polycyclic aromatic hydrocarbons (PAH); Adolescents; Estimated
   glomerular filtration rate (eGFR); National Health and Nutrition
   Examination; Survey (NHANES); C-reactive protein (CRP); Gamma glutamyl
   transferase (GGT)
ID GAMMA-GLUTAMYL-TRANSFERASE; SERUM URIC-ACID; TOBACCO-SMOKE EXPOSURE;
   C-REACTIVE PROTEIN; UNITED-STATES; INSULIN-RESISTANCE; METABOLIC
   SYNDROME; IN-VITRO; ENDOTHELIAL DYSFUNCTION; CARDIOVASCULAR-DISEASES
AB Objective: Recent evidence has suggested that polycyclic aromatic hydrocarbons (PAHs) may contribute to cardiometabolic and kidney dysfunction by increasing oxidative stress, but little is known about impacts in childhood.
   Study design: We performed cross-sectional analyses of 660 adolescents aged 12-19 years in the 20032008 National Health and Nutrition Examination Survey (NHANES), using levels of 10 monohydroxylated urinary PAH metabolites as our exposure. Our primary outcomes of interest were biomarkers of oxidative stress and renal function, including estimated glomerular filtration rate (eGFR), urinary albumin to creatinine ratio (ACR), insulin resistance, and serum uric acid, gamma glutamyl transferase (GGT) and C-reactive protein (CRP).
   Results: We observed statistically significant associations between PAH metabolites and levels of serum GGT, CRP, uric acid and eGFR. Each 100% increase in 2-hydroxyphenanthrene was related to a 336% increase in uric acid (95% CI: 0.338-6.372; p=0.032), a 3.86% increase in GGT (95% Cl: 1.361-6.362; p=0.005) and a 16.78% increase in CRP (95% Cl: 1.848-31.689; p=0.029). Each 100% increase in 4-hydroxyphenanthrene was associated with a 6.18% increase in GGT (95% CI: 4.064-8301; p < 0.001) and a 13.66% increase in CRP (95% CI: 2.764-24.564; p=0.017). Each 100% increase in 9-hydroxyfluorene was associated with a 2.58% increase in GGT (95% CI: 0389-4776; p=0.024). Each 100% increase in 3-hydroxyphenanthrene was associated with a 2.66% decrease in eGFR (95% Cl: -4.979 to -0.331; p= 0.028).
   Conclusions: Urinary PAH metabolites were associated with serum uric acid, GGT and CRP, suggesting possible impacts on cardiometabolic and kidney function in adolescents. Prospective work is needed to investigate the potential long-term health consequences of these findings. (C) 2015 Elsevier Inc. All rights reserved.
C1 [Farzan, Shohreh F.] Geisel Sch Med Dartmouth, Dept Epidemiol, Lebanon, NH 03756 USA.
   [Farzan, Shohreh F.; Chen, Yu; Trasande, Leonardo] NYU, Sch Med, Dept Populat Hlth, New York, NY USA.
   [Trachtman, Howard; Trasande, Leonardo] NYU, Sch Med, Dept Pediat, New York, NY USA.
   [Trasande, Leonardo] NYU, Sch Med, Dept Environm Med, New York, NY USA.
   [Trasande, Leonardo] NYU, Wagner Sch Publ Serv, New York, NY USA.
   [Trasande, Leonardo] NYU, Steinhardt Sch Culture Educ & Human Dev, Dept Nutr Food & Publ Hlth, New York, NY 10003 USA.
C3 Dartmouth College; New York University; New York University; New York
   University; New York University; New York University
RP Farzan, SF (corresponding author), Geisel Sch Med Dartmouth, Dept Epidemiol, One Med Ctr Dr, Lebanon, NH 03756 USA.
EM shohreh.farzan@dartmouth.edu
RI Trachtman, Howard/GSE-2340-2022; Chen, Yu/KWU-0062-2024; Trasande,
   Leonardo/ABE-6339-2020
OI Trachtman, Howard/0000-0001-7447-9489; Trasande,
   Leonardo/0000-0002-1928-597X; Chen, Yu/0000-0002-1519-4894
FU NIEHS [K99ES024144, R01ES017541, P30ES000260, R01ES022972]; NIDDK
   [R01DK100307]
FX This work was supported in part by Grants NIEHS K99ES024144 (SFF), NIEHS
   R01ES017541 (YC), NIEHS P30ES000260 (YC), NIDDK R01DK100307 (LT/HT) and
   NIEHS R01ES022972 (LT). The authors have no conflicts of interest to
   disclose. The funding agencies had no role in the study design, the
   collection, analysis, and interpretation of data, the writing of the
   report, or the decision to submit this manuscript for publication.
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NR 87
TC 100
Z9 113
U1 2
U2 57
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0013-9351
EI 1096-0953
J9 ENVIRON RES
JI Environ. Res.
PD JAN
PY 2016
VL 144
BP 149
EP 157
DI 10.1016/j.envres.2015.11.012
PN A
PG 9
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA CY5HO
UT WOS:000366438900016
PM 26610293
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Monte, SV
   Caruana, JA
   Ghanim, H
   Sia, CL
   Korzeniewski, K
   Schentag, JJ
   Dandona, P
AF Monte, Scott V.
   Caruana, Joseph A.
   Ghanim, Husam
   Sia, Chang Ling
   Korzeniewski, Kelly
   Schentag, Jerome J.
   Dandona, Paresh
TI Reduction in endotoxemia, oxidative and inflammatory stress, and insulin
   resistance after Roux-en-Y gastric bypass surgery in patients with
   morbid obesity and type 2 diabetes mellitus
SO SURGERY
LA English
DT Article
ID NONALCOHOLIC FATTY LIVER; TOLL-LIKE RECEPTOR-4; WEIGHT-LOSS; METABOLIC
   SYNDROME; EFFECTIVE THERAPY; GLUCOSE; NIDDM; LIFE
AB Background. Roux-en-Y gastric bypass (RYGB) results in profound weight loss and resolution of type 2 diabetes mellitus (T2DM). The mechanism of this remarkable transition remains poorly defined. It has been proposed that endotoxin (lipapolysaccharide [LPS]) sets inflammatory) tone, triggers weight gain, and initiates T2DM. Because RYGB may diminish LPS from endogenous and exogenous sources, we hypothesized that LPS and the associated cascade of oxidative and inflammatory stress would diminish after RYGB.
   Methods. Fifteen adults with morbid obesity and T2DM undergoing RYGB were studied. After an overnight fast, a baseline blood sample was collected the morning of surgery and at 180 days to assess changes in glycemia, insulin resistance, LPS, mononuclear cell nuclear factor (NF)-kappa B binding and mRNA expression of CD14, TLR-2, TLR-4, and markers of inflammatory stress.
   Results. At 180 days after RYGB, subjects had a significant decrease in body mass index (52.1 +/- 13.0 to 40.4 +/- 11.1), plasma glucose (148 +/- 8 to 101 +/- 4 mg/dL), insulin (18.5 +/- 2.2 m mu U/mL to 8.6 +/- 1.0 m mu U/mL) and HOMA-IR (7.1 +/- 1.1 to 2.1 +/- 0.3). Plasma LPS significantly reduced by 20 +/- 5% (0.567 +/- 0.033 U/mL to 0.443 +/- 0.022E U/mL). NE-kappa B DNA binding decreased significantly by 21 +/- 8%, whereas TLR-4, TLR-2, and CD-14 expression decreased significantly by 25 +/- 9%, 42 +/- 8%, and 27 +/- 10%, respectively. Inflammatory mediators CRP MMP-9, and MCP-1 decreased significantly by 47 +/- 7% (10.7 +/- 1.6 mg/L to 5.8 +/- 1.0 mg/L), 15 +/- 6% (492 +/- 42 ng/mL to 356 +/- 26 ng/mL) and 11 +/- 4% (522 +/- 35 ng/mL to 466 +/- 35 ng/mL), respectively.
   Conclusion. LPS, NE-kappa B DNA binding, TLR-4, TLR-2, and CD14 expression, CRP, MMP-9, and MCP-1 decreased significantly after RYGB. The mechanism underlying resolution of insulin resistance and T2DM after RYGB may be attributable, at least in part, to the reduction of endotoxemia and associated proinflammatory mediators. (Surgery 2012;151:587-93.)
C1 [Monte, Scott V.] CPL Associates LLC, Diabet & Cardiovasc Res, Buffalo, NY 14225 USA.
   [Monte, Scott V.; Schentag, Jerome J.] SUNY Buffalo, Sch Pharm & Pharmaceut Sci, Amherst, NY USA.
   [Caruana, Joseph A.] SUNY Buffalo, Dept Surg Sisters, Char Hosp, Buffalo, NY 14260 USA.
   [Ghanim, Husam; Sia, Chang Ling; Korzeniewski, Kelly; Dandona, Paresh] SUNY Buffalo, Div Endocrinol, Buffalo, NY 14260 USA.
C3 State University of New York (SUNY) System; University at Buffalo, SUNY;
   State University of New York (SUNY) System; University at Buffalo, SUNY;
   State University of New York (SUNY) System; University at Buffalo, SUNY
RP Monte, SV (corresponding author), CPL Associates LLC, Diabet & Cardiovasc Res, 4455 Genesee St, Buffalo, NY 14225 USA.
EM smonte@cplassociates.com
FU NIH [R01 DK069805, R01 DK075877]; American Diabetes Association
   [708CR13]; Merck; Amylin; Abbott Pharmaceuticals
FX Supported by grants from NIH (R01 DK069805 and R01 DK075877) and the
   American Diabetes Association (708CR13) and by grants from Merck,
   Amylin, and Abbott Pharmaceuticals.
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NR 30
TC 120
Z9 136
U1 0
U2 11
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0039-6060
J9 SURGERY
JI Surgery
PD APR
PY 2012
VL 151
IS 4
BP 587
EP 593
DI 10.1016/j.surg.2011.09.038
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 915AZ
UT WOS:000301996600013
PM 22088821
DA 2025-06-11
ER

PT J
AU Noeman, SA
   Hamooda, HE
   Baalash, AA
AF Noeman, Saad A.
   Hamooda, Hala E.
   Baalash, Amal A.
TI Biochemical Study of Oxidative Stress Markers in the Liver, Kidney and
   Heart of High Fat Diet Induced Obesity in Rats
SO DIABETOLOGY & METABOLIC SYNDROME
LA English
DT Article
ID PLASMA-LIPID PEROXIDATION; METABOLIC SYNDROME; ENZYMATIC METHOD;
   GLUTATHIONE; CARBONYL; CHOLESTEROL; BIOMARKERS; MODELS; DAMAGE; BLOOD
AB Background: Obesity has become a leading global health problem owing to its strong association with a high incidence of diseases.
   Aim: To induce rat obesity using high fat diet (HFD) and to estimate oxidative stress markers in their liver, heart and kidney tissues in order to shed the light on the effect of obesity on these organs.
   Materials and methods: Sixty white albino rats weighing 150-200 g were randomly divided into two equal groups; group I: received high fat diet for 16 weeks, and group II (control group): received only normal diet (rat chow) for 16 weeks. Blood samples were taken for measurement of lipid profile, tissue samples from liver, heart and kidney were taken for determination of malondialdehyde (MDA), protein carbonyl (PCO), reduced glutathione (GSH) levels, and the activities of glutathione S-transferase (GST) glutathione peroxidase (GPx), catalase (CAT) and paraoxonase1 (PON1) enzymes.
   Results: Data showed that feeding HFD diet significantly increased final body weight and induced a state of dyslipideamia. Also our results showed a significant increase MDA and PCO levels in the hepatic, heart and renal tissues of obese rats, as well as a significant decrease in the activity of GST, GPx and PON 1 enzymes. On the other hand CAT enzyme activity showed significant decrease only in renal tissues of obese rats with non significant difference in hepatic and heart tissues. GSH levels showed significant decrease in both renal and hepatic tissues of obese animals and significant increase in their heart tissues. Correlation studies in obese animals showed a negative correlation between MDA and PCO tissue levels and the activities of GPx, GST and PON1 in all tissues and also with CAT enzyme activity in renal tissues. Also a negative correlation was detected between MDA & PCO tissues levels and GSH levels in both hepatic and renal tissues. While positive correlation was found between them and GSH levels in heart tissues.
   Conclusion: High fat diet-induced obesity is accompanied by increased hepatic, heart, and renal tissues oxidative stress, which is characterized by reduction in the antioxidant enzymes activities and glutathione levels, that correlate with the increase in MDA and PCO levels in most tissues. This may probably contribute to the additional progression of obesity related problems.
C1 [Noeman, Saad A.; Hamooda, Hala E.; Baalash, Amal A.] Tanta Univ, Fac Med, Dept Med Biochem, Tanta, Egypt.
C3 Egyptian Knowledge Bank (EKB); Tanta University
RP Noeman, SA (corresponding author), Tanta Univ, Fac Med, Dept Med Biochem, Tanta, Egypt.
EM nooman1234@hotmail.com
RI Baalash, Amal/JLL-6700-2023
OI noeman, saad/0000-0002-0964-6057; BALSH, AMAL/0000-0002-3352-3073
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NR 56
TC 337
Z9 365
U1 1
U2 34
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1758-5996
J9 DIABETOL METAB SYNDR
JI Diabetol. Metab. Syndr.
PD AUG 3
PY 2011
VL 3
AR 17
DI 10.1186/1758-5996-3-17
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 822IG
UT WOS:000295037000001
PM 21812977
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Kharche, SR
   So, A
   Salerno, F
   Lee, TY
   Ellis, C
   Goldman, D
   McIntyre, CW
AF Kharche, Sanjay R.
   So, Aaron
   Salerno, Fabio
   Lee, Ting-Yim
   Ellis, Chris
   Goldman, Daniel
   McIntyre, Christopher W.
TI Computational Assessment of Blood Flow Heterogeneity in Peritoneal
   Dialysis Patients' Cardiac Ventricles
SO FRONTIERS IN PHYSIOLOGY
LA English
DT Article
DE coronary vessels; cardiac physiology; mathematical modeling;
   computational physiology; integrative physiology
ID CORONARY ARTERIAL TREE; MICROVASCULAR PERFUSION HETEROGENEITY; DETAILED
   ANATOMICAL DATA; CHRONIC KIDNEY-DISEASE; MYOCARDIAL-PERFUSION; VASCULAR
   NETWORKS; SPATIAL HETEROGENEITY; COMPUTED-TOMOGRAPHY; BRANCHING
   PATTERNS; METABOLIC SYNDROME
AB Dialysis prolongs life but augments cardiovascular mortality Imaging data suggests that dialysis increases myocardial blood flow (BF) heterogeneity, but its causes remain poorly understood A biophysical model of human coronary vasculature was used to explain the imaging observations, and highlight causes of coronary BF heterogeneity. Post-dialysis CT images from patients under control, pharmacological stress (adenosine), therapy (cooled dialysate), and adenosine and cooled dialysate conditions were obtained. The data presented disparate phenotypes. To dissect vascular mechanisms, a 3D human vasculature model based on known experimental coronary morphometry and a space filling algorithm was implemented. Steady state simulations were performed to investigate the effects of altered aortic pressure and blood vessel diameters on myocardial BF heterogeneity. Imaging showed that stress and therapy potentially increased mean and total BF, while reducing heterogeneity. BF histograms of one patient showed multi-modality. Using the model, it was found that total coronary BF increased as coronary perfusion pressure was increased. BF heterogeneity was differentially affected by large or small vessel blocking. BF heterogeneity was found to be inversely related to small blood vessel diameters. Simulation of large artery stenosis indicates that BF became heterogeneous (increase relative dispersion) and gave multi-modal histograms. The total transmural BF as well as transmural BF heterogeneity reduced due to large artery stenosis, generating large patches of very low BF regions downstream. Blocking of arteries at various orders showed that blocking larger arteries results in multi-modal BF histograms and large patches of low BF, whereas smaller artery blocking results in augmented relative dispersion and fractal dimension. Transmural heterogeneity was also affected. Finally, the effects of augmented aortic pressure in the presence of blood vessel blocking shows differential effects on BF heterogeneity as well as transmural BF Improved aortic blood pressure may improve total BF. Stress and therapy may be effective if they dilate small vessels. A potential cause for the observed complex BF distributions (multi-modal BF histograms) may indicate existing large vessel stenosis. The intuitive BF heterogeneity methods used can be readily used in clinical studies. Further development of the model and methods will permit personalized assessment of patient BF status.
C1 [Kharche, Sanjay R.; Salerno, Fabio; McIntyre, Christopher W.] Victoria Hosp, Lawsons Hlth Res Inst, Kidney Clin Res Unit, London, ON, Canada.
   [Kharche, Sanjay R.; So, Aaron; Ellis, Chris; Goldman, Daniel; McIntyre, Christopher W.] Univ Western Ontario, Dept Med Biophys, Schulich Sch Med & Dent, London, ON, Canada.
   [So, Aaron; Lee, Ting-Yim] Univ Western Ontario, Robarts Res Inst, London, ON, Canada.
C3 Western University (University of Western Ontario); University Western
   Ontario Hospital; University of Victoria; Western University (University
   of Western Ontario); Western University (University of Western Ontario);
   University Western Ontario Hospital
RP Kharche, SR; McIntyre, CW (corresponding author), Victoria Hosp, Lawsons Hlth Res Inst, Kidney Clin Res Unit, London, ON, Canada.; Kharche, SR; McIntyre, CW (corresponding author), Univ Western Ontario, Dept Med Biophys, Schulich Sch Med & Dent, London, ON, Canada.
EM sanjay.kharche@lhsc.on.ca; c.w.mcintyre@lhsc.on.ca
RI Lee, Ting-Yim/M-1721-2013; Ellis, Christopher/AAV-2325-2020; McIntyre,
   Christopher/O-8927-2014; Goldman, Daniel/CAI-2887-2022; So,
   Aaron/B-6088-2015; Kharche, Sanjay R./I-2130-2014; Ellis,
   Christopher/G-8649-2013
OI Kharche, Sanjay R./0000-0002-2634-4894; Goldman,
   Daniel/0000-0002-8707-5536; Lee, Ting-Yim/0000-0001-7605-9752; Ellis,
   Christopher/0000-0002-7760-1846
FU Heart and Stroke grant [G-17-0018311]
FX We thank LHSC IT, Compute Canada, SHARCNet for IT and HPC resources.
   This study was supported by Heart and Stroke grant (G-17-0018311, PI:
   CM).
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NR 67
TC 8
Z9 10
U1 0
U2 6
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-042X
J9 FRONT PHYSIOL
JI Front. Physiol.
PD MAY 17
PY 2018
VL 9
AR 511
DI 10.3389/fphys.2018.00511
PG 16
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA GG0ZX
UT WOS:000432410200001
PM 29867555
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Crescenzo, R
   Mazzoli, A
   Cancelliere, R
   Bianco, F
   Giacco, A
   Liverini, G
   Dulloo, AG
   Iossa, S
AF Crescenzo, Raffaella
   Mazzoli, Arianna
   Cancelliere, Rosa
   Bianco, Francesca
   Giacco, Antonia
   Liverini, Giovanna
   Dulloo, Abdul G.
   Iossa, Susanna
TI Polyunsaturated Fatty Acids Stimulate De novo Lipogenesisand
   Improve Glucose Homeostasis during Refeeding with High Fat Diet
SO FRONTIERS IN PHYSIOLOGY
LA English
DT Article
DE caloric restriction; polyunsaturated fatty acids; de novo lipogenesis;
   hepatic inflammation; insulin resistance
ID CATCH-UP FAT; SKELETAL-MUSCLE; ADIPOSE-TISSUE; INSULIN SENSITIVITY;
   METABOLIC SYNDROME; CALORIC RESTRICTION; ENERGY-BALANCE; BODY-WEIGHT;
   GROWTH; RATS
AB Aims: The recovery of body weight after a period of caloric restriction is accompanied by an enhanced efficiency of fat deposition and hyperinsulinemia-which are exacerbated by isocaloric refeeding on a high fat diet rich in saturated and monounsaturated fatty acids (SFA-MUFA), and poor in polyunsaturated fatty acids (PUFA), and associated with a blunting of de novo lipogenesis in adipose tissue and liver. As high fat diets rich in PUFA have been shown to limit the excess fat deposition and improve glucose homeostasis, we investigated here the extent to which de novo lipogenesis in liver and adipose tissues (white and brown), as well as hepatic oxidative stress, are influenced by refeeding on diets rich in PUFA.
   Design: In rats calorically restricted for 14 days and refed for 14 days on isocaloric amounts of a high fat diet rich in lard (i.e., high SFA-MUFA) or in safflower and linseed oils (rich in PUFA), we investigated energy balance, body composition, glycemic profile, and the regulation of fatty acid synthase (rate-limiting enzyme of de novo lipogenesis) in liver, white and brown adipose tissue. We also evaluated oxidative stress in liver and skeletal muscle and markers of hepatic inflammation.
   Results: Rats refed the PUFA diet gained less lipids and more proteins compared to rats refed SFA-MUFA diet and showed lower amount of visceral and epididymal white adipose tissue, but increased depots of interscapular brown adipose tissue, with higher expression of the uncoupling protein 1. A significant increase in non-protein respiratory quotient and carbohydrate utilization was found in rats refed PUFA diet. Rats refed PUFA diet showed improved glucose homeostasis, as well as lower triglycerides and cholesterol levels. Fatty acid synthase activity was significantly higher in liver, white and brown adipose tissue, while lipid peroxidation and the degree of inflammation in the liver were significantly lower, in rats refed PUFA diet.
   Conclusions: When considering the composition of high fat diets for nutritional rehabilitation, the inclusion of PUFA could be useful for improving protein deposition and maintaining glucose homeostasis, while limiting lipid storage in adipose tissue and oxidative stress and inflammation in the liver.
C1 [Crescenzo, Raffaella; Mazzoli, Arianna; Cancelliere, Rosa; Bianco, Francesca; Giacco, Antonia; Liverini, Giovanna; Iossa, Susanna] Univ Naples Federico II, Dept Biol, Naples, Italy.
   [Dulloo, Abdul G.] Univ Fribourg, Dept Med, Div Physiol, Fribourg, Switzerland.
C3 University of Naples Federico II; University of Fribourg
RP Iossa, S (corresponding author), Univ Naples Federico II, Dept Biol, Naples, Italy.
EM susiossa@unina.it
RI ; IOSSA, Susanna/O-1625-2016
OI DULLOO, Abdul/0000-0003-3877-6149; mazzoli, arianna/0000-0003-4096-443X;
   IOSSA, Susanna/0000-0001-6103-718X
FU University "Federico II" of Naples; Swiss National Science Foundation
   [310030-152870]; Swiss National Science Foundation (SNF) [310030_152870]
   Funding Source: Swiss National Science Foundation (SNF)
FX This work was supported by grant from University "Federico II" of
   Naples, and by the Swiss National Science Foundation (grant no.
   310030-152870).
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NR 36
TC 17
Z9 17
U1 1
U2 16
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA PO BOX 110, EPFL INNOVATION PARK, BUILDING I, LAUSANNE, 1015,
   SWITZERLAND
SN 1664-042X
J9 FRONT PHYSIOL
JI Front. Physiol.
PD MAR 23
PY 2017
VL 8
AR 178
DI 10.3389/fphys.2017.00178
PG 9
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA EP0OY
UT WOS:000397087800001
PM 28386235
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Yang, KM
   Forman, MR
   Monahan, PO
   Graham, BH
   Chan, AT
   Zhang, XH
   De Vivo, I
   Giovannucci, EL
   Tabung, FK
   Nan, HM
AF Yang, Keming
   Forman, Michele R.
   Monahan, Patrick O.
   Graham, Brett H.
   Chan, Andrew T.
   Zhang, Xuehong
   De Vivo, Immaculata
   Giovannucci, Edward L.
   Tabung, Fred K.
   Nan, Hongmei
TI Insulinemic Potential of Lifestyle Is Inversely Associated with
   Leukocyte Mitochondrial DNA Copy Number in US White Adults
SO JOURNAL OF NUTRITION
LA English
DT Article
DE mitochondria; mitochondrial DNA copy number; lifestyle index; insulin
   insensitivity; hyperinsulinemia; cross-sectional study
ID METABOLIC SYNDROME; OXIDATIVE STRESS; DIETARY PATTERNS; CANCER-RISK;
   C-PEPTIDE; HYPERINSULINEMIA; RESISTANCE; VALIDATION; HEALTH;
   QUESTIONNAIRE
AB Background: Poor lifestyles have been linked to insulin insensitivity/hyperinsulinemia, which may contribute to downstream changes such as inflammation and oxidative damage and the development of chronic diseases. As a biomarker of intracellular oxidative stress, leukocyte mitochondrial DNA copy number (mtDNA-CN) has been related to lifestyle factors including diet and weight. No epidemiologic study has examined the relation between combined insulinemic potential of lifestyle and mtDNA-CN.
   Objectives: Our aim was to examine the association between Empirical Lifestyle Index for Hyperinsulinemia (ELIH) and leukocyte mtDNA-CN in US men and women.
   Methods: This cross-sectional analysis included 2835 white adults without cancers, diabetes, or cardiovascular disease at blood collection, including 2160 women from the Nurses' Health Study and 675 men from the Health Professionals Follow-Up Study. ELIH is an index based on plasma C-peptide that characterizes the insulinemic potential of lifestyle (diet, body weight, and physical activity). Relative mtDNA-CN in peripheral blood leukocytes was measured by qPCR-based assay.
   Results: We found a significant inverse association between ELIH and mtDNA-CN. In multivariable-adjusted linear models, absolute least squaresmeans +/- SDs of mtDNA-CN z score across ELIH quintiles in women were as follows: Q1: 0.14 +/- 0.05; Q2: 0.04 +/- 0.06; Q3: 0.008 +/- 0.05; Q4: 0.01 +/- 0.05; and Q5: -0.06 +/- 0.05 (P-trend = 0.006). Means +/- SDs in men were as follows: Q1: 0.25 +/- 0.09; Q2: 0.23 +/- 0.09; Q3: 0.07 +/- 0.09; Q4: 0.02 +/- 0.09; and Q5: -0.04 +/- 0.09 (P- trend = 0.007). Means +/- SDs in all participants were as follows: Q1: 0.16 +/- 0.05; Q2: 0.07 +/- 0.05; Q3: 0.01 +/- 0.05; Q4: 0.01 +/- 0.05; and Q5: -0.05 +/- 0.05 (P-trend = 0.0004).
   Conclusions: Hyperinsulinemic lifestyles (i.e., higher ELIH) were associated with lower leukocyte mtDNA-CN among subjects without major diseases, suggesting that the difference in lifestyle insulinemic potential may be related to excessive oxidative stress damage.
C1 [Yang, Keming; Zhang, Xuehong; Giovannucci, Edward L.; Tabung, Fred K.] Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA.
   [Yang, Keming; Nan, Hongmei] Indiana Univ, Richard M Fairbanks Sch Publ Hlth, Dept Epidemiol, Indianapolis, IN 46204 USA.
   [Forman, Michele R.] Purdue Univ, Purdue Ctr Canc Res, Coll Hlth & Human Sci, Dept Nutr Sci, W Lafayette, IN 47907 USA.
   [Monahan, Patrick O.] Indiana Univ, Sch Med, Dept Biostat, Indianapolis, IN 46204 USA.
   [Monahan, Patrick O.] Indiana Univ, Richard M Fairbanks Sch Publ Hlth, Indianapolis, IN 46204 USA.
   [Graham, Brett H.] Indiana Univ Sch Med, Dept Med & Mol Genet, Indianapolis, IN 46202 USA.
   [Chan, Andrew T.] Massachusetts Gen Hosp, Clin & Translat Epidemiol Unit, Boston, MA 02114 USA.
   [Chan, Andrew T.] Massachusetts Gen Hosp, Div Gastroenterol, Boston, MA 02114 USA.
   [Chan, Andrew T.; Zhang, Xuehong; De Vivo, Immaculata; Giovannucci, Edward L.] Harvard Med Sch, Boston, MA 02115 USA.
   [Chan, Andrew T.; Zhang, Xuehong; De Vivo, Immaculata; Giovannucci, Edward L.] Brigham & Womens Hosp, Dept Med, Charming Div Network Med, 75 Francis St, Boston, MA 02115 USA.
   [De Vivo, Immaculata; Giovannucci, Edward L.] Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA.
   [Tabung, Fred K.] Ohio State Univ, Dept Internal Med, Coll Med, Columbus, OH 43210 USA.
   [Tabung, Fred K.] Comprehens Canc Ctr, Columbus, OH 43202 USA.
   [Nan, Hongmei] Indiana Univ, Richard M Fairbanks Sch Publ Hlth, Dept Global Hlth, Indianapolis, IN 46204 USA.
   [Nan, Hongmei] Indiana Univ, IU Melvin & Bren Simon Canc Ctr, Indianapolis, IN 46204 USA.
C3 Harvard University; Harvard T.H. Chan School of Public Health; Indiana
   University System; Indiana University Indianapolis; Purdue University
   System; Purdue University; Indiana University System; Indiana University
   Indianapolis; Indiana University System; Indiana University
   Indianapolis; Indiana University System; Indiana University Bloomington;
   Harvard University; Harvard University Medical Affiliates; Massachusetts
   General Hospital; Harvard University; Harvard University Medical
   Affiliates; Massachusetts General Hospital; Harvard University; Harvard
   Medical School; Harvard University; Harvard University Medical
   Affiliates; Brigham & Women's Hospital; Harvard University; Harvard T.H.
   Chan School of Public Health; University System of Ohio; Ohio State
   University; James Cancer Hospital & Solove Research Institute; Indiana
   University System; Indiana University Indianapolis; Indiana University
   System; Indiana University Indianapolis
RP Tabung, FK (corresponding author), Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA.; Nan, HM (corresponding author), Indiana Univ, Richard M Fairbanks Sch Publ Hlth, Dept Epidemiol, Indianapolis, IN 46204 USA.; Tabung, FK (corresponding author), Ohio State Univ, Dept Internal Med, Coll Med, Columbus, OH 43210 USA.; Tabung, FK (corresponding author), Comprehens Canc Ctr, Columbus, OH 43202 USA.; Nan, HM (corresponding author), Indiana Univ, Richard M Fairbanks Sch Publ Hlth, Dept Global Hlth, Indianapolis, IN 46204 USA.; Nan, HM (corresponding author), Indiana Univ, IU Melvin & Bren Simon Canc Ctr, Indianapolis, IN 46204 USA.
EM Fred.Tabung@osumc.edu; hnan@iu.edu
RI Tabung, Fred/AAQ-7823-2021; Zhang, Xuehong/E-6219-2012; Giovannucci,
   Edward/ADE-8028-2022; Chan, Andrew/ADM-9271-2022
OI Tabung, Fred/0000-0001-8193-7150; De Vivo,
   Immaculata/0000-0002-7185-7402; Nan, Hongmei/0000-0002-9957-616X
FU NIH [UM1 CA186107, R01 CA49449, R01 CA137178, R00 CA207736, U01
   CA167552]
FX This work was supported by NIH grants UM1 CA186107, R01 CA49449, R01
   CA137178, R00 CA207736, and U01 CA167552. The content is solely the
   responsibility of the authors and does not necessarily represent the
   official views of the National Institutes of Health. The authors assume
   full responsibility for analyses and interpretation of the data.
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NR 47
TC 5
Z9 5
U1 0
U2 5
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0022-3166
EI 1541-6100
J9 J NUTR
JI J. Nutr.
PD AUG
PY 2020
VL 150
IS 8
BP 2156
EP 2163
DI 10.1093/jn/nxaa146
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA MU9GK
UT WOS:000555973600021
PM 32492151
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Jergovic, M
   Bendelja, K
   Mlakar, AS
   Vojvoda, V
   Aberle, N
   Jovanovic, T
   Rabatic, S
   Sabioncello, A
   Vidovic, A
AF Jergovic, Mladen
   Bendelja, Kreso
   Mlakar, Ana Savic
   Vojvoda, Valerija
   Aberle, Neda
   Jovanovic, Tanja
   Rabatic, Sabina
   Sabioncello, Ante
   Vidovic, Andelko
TI Circulating levels of hormones, lipids, and immune mediators in
   post-traumatic stress disorder - a 3-month follow-up study
SO FRONTIERS IN PSYCHIATRY
LA English
DT Article
DE post-traumatic stress disorder; veterans; biological markers;
   cholesterol; cytokines; cell adhesion molecules; nerve growth factor;
   leptin
ID DEHYDROEPIANDROSTERONE-SULFATE; INFLAMMATORY BIOMARKERS; ENDOTHELIAL
   DYSFUNCTION; EARTHQUAKE SURVIVORS; NEUROTROPHIC FACTOR; PROLACTIN
   RESPONSE; METABOLIC SYNDROME; SERUM CORTISOL; D-FENFLURAMINE; WAR
   VETERANS
AB A number of peripheral blood analytes have been proposed as potential biomarkers of post-traumatic stress disorder (PTSD). Few studies have investigated whether observed changes in biomarkers persist over time. The aim of this study was to investigate the association of combat-related chronic PTSD with a wide array of putative PTSD biomarkers and to determine reliability of the measurements, i.e., correlations over time. Croatian combat veterans with chronic PTSD (n= 69) and age-matched healthy controls (n= 32), all men, were assessed at two time points separated by 3 months. Serum levels of lipids, cortisol, dehydroepiandrosterone-sulfate (DHEA-S), prolactin, and C-reactive protein were determined. Multiplex assay was used for the simultaneous assessment of 13 analytes in sera: cytokines [interferon-gamma, interleukin (IL)-1 beta, IL-2, IL-4, IL-6, TNF-alpha], adhesion molecules (sPECAM-1, sICAM-1), chemokines (IL-8 and MIP-1 alpha), sCD40L, nerve growth factor, and leptin. Group differences and changes over time were tested by parametric or nonparametric tests, including repeated measures analysis of covariance. Reliability estimates [intraclass correlation coefficient (ICC) and kappa] were also calculated. Robust associations of PTSD with higher levels of DHEA-S F(1,75) = 8.14, p= 0.006)] and lower levels of prolactin F(1,75) = 5.40, p = 0.023] were found. Measurements showed good to excellent reproducibility (DHEA-S, ICC = 0.50; prolactin, ICC = 0.79). Serum lipids did not differ between groups but significant increase of LDLC after 3 months was observed in the PTSD group (t = 6.87, p < 0.001). 1158 was lower in the PTSD group (t = 4.37, p < 0.001) but assessments showed poor reproducibility (ICC = -0.08). Stable DHEA-S and prolactin changes highlight their potential to be reliable markers of PTSD. Change in lipid profiles after 3 months suggests that PTSD patients may be more prone to hyperlipidemia. High intraindividual variability in some variables emphasizes the importance of longitudinal studies in investigations of PTSD biomarkers.
C1 [Jergovic, Mladen; Bendelja, Kreso; Mlakar, Ana Savic; Vojvoda, Valerija] Univ Zagreb, Ctr Res & Knowledge Transfer Biotechnol, Zagreb 41000, Croatia.
   [Jergovic, Mladen; Rabatic, Sabina; Sabioncello, Ante] Inst Immunol, Dept Cellular Immunol, Zagreb, Croatia.
   [Aberle, Neda] Dr Josip Bencevic Gen Hosp, Slavonski Brod, Croatia.
   [Jovanovic, Tanja] Emory Univ, Dept Psychiat & Behav Sci, Atlanta, GA 30322 USA.
   [Vidovic, Andelko] Univ Hosp Dubrava, Dept Psychiat, HR-10000 Zagreb, Croatia.
C3 University of Zagreb; Emory University
RP Vidovic, A (corresponding author), Univ Hosp Dubrava, Referral Ctr Stress Related Disorders, Dept Psychiat, Ave Gojka Suska 6, HR-10000 Zagreb, Croatia.
EM avidovic@gmail.com
RI Mlakar, Ana/C-6305-2016; Jovanovic, Tanja/K-4095-2014
OI Savic Mlakar, Ana/0000-0003-4679-3563; Bendelja,
   Kreso/0000-0002-6017-3355
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NR 101
TC 56
Z9 61
U1 0
U2 27
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-0640
J9 FRONT PSYCHIATRY
JI Front. Psychiatry
PD APR 14
PY 2015
VL 6
AR 49
DI 10.3389/fpsyt.2015.00049
PG 13
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA CV5XL
UT WOS:000364344700001
PM 25926799
OA Green Published
DA 2025-06-11
ER

PT J
AU Rahmani, AH
   Alsahli, MA
   Khan, AA
   Almatroodi, SA
AF Rahmani, Arshad Husain
   Alsahli, Mohammed A. A.
   Khan, Amjad Ali
   Almatroodi, Saleh A. A.
TI Quercetin, a Plant Flavonol Attenuates Diabetic Complications, Renal
   Tissue Damage, Renal Oxidative Stress and Inflammation in
   Streptozotocin-Induced Diabetic Rats
SO METABOLITES
LA English
DT Article
DE quercetin; anti-diabetic activity; oxidative stress; reno-protective
   effect; anti-inflammatory activity
ID NEPHROPATHY; ANTIOXIDANT; NARINGENIN; EXPRESSION; EXTRACT; OBESITY;
   FRUIT
AB Diabetes mellitus is a metabolic syndrome characterized by increased glucose levels, oxidative stress, hyperlipidemia, and frequently decreased insulin levels. The current research was carried out for eight consecutive weeks to evaluate the possible reno-protective effects of quercetin (50 mg/kg b.w.) on streptozotocin (STZ) (55 mg/kg b.w.) induced diabetes rat models. Various physiological, biochemical, and histopathological parameters were determined in control, diabetic control, and quercetin-treated diabetic rats. The current findings demonstrated that diabetes control rats showed significantly decreased body weights (198 +/- 10 vs. 214 +/- 13 g) and insulin levels (0.28 +/- 0.04 vs. 1.15 +/- 0.05 ng/mL) in comparison to normal control. Besides this, the other parameters showed increased values, such as fasting blood glucose, triglyceride (TG), and total cholesterol levels (99 +/- 5 vs. 230 +/- 7 mg/dL, 122.9 +/- 8.7 vs. 230.7 +/- 7.2 mg/dL, 97.34 +/- 5.7 vs. 146.3 +/- 8 mg/dL) (p < 0.05). In addition, the urea and creatinine levels (39.9 +/- 1.8 mg/dL and 102.7 +/- 7.8 mu mol/L) were also high in diabetes control rats. After 8 weeks of quercetin treatment in STZ-treated animals, body weight, insulin, and fasting blood sugar levels were significantly restored (p < 0.05). The inflammatory markers (TNF-alpha, IL-6, and IL-1 beta) were significantly increased (52.64 +/- 2, 95.64 +/- 3, 23.3 +/- 1.2 pg/mL) and antioxidant enzymes levels (SOD, GST, CAT, and GSH) were significantly decreased (40.3 +/- 3 U/mg, 81.9 +/- 10 mU/mg, 14.2 +/- 2 U/mg, 19.9 +/- 2 mu mol/g) in diabetic rats. All the parameters in diabetic animals treated with quercetin were restored towards their normal values. Histopathological findings revealed that the quercetin-treated group showed kidney architecture maintenance, reduction of fibrosis, and decreased expression of COX-2 protein. These results determined that quercetin has reno-protective effects, and conclude that quercetin possesses a strong antidiabetic potential and might act as a therapeutic agent in the prevention or delay of diabetes-associated kidney dysfunction.
C1 [Rahmani, Arshad Husain; Alsahli, Mohammed A. A.; Almatroodi, Saleh A. A.] Qassim Univ, Coll Appl Med Sci, Dept Med Labs, Buraydah 52571, Saudi Arabia.
   [Khan, Amjad Ali] Qassim Univ, Coll Appl Med Sci, Dept Basic Hlth Sci, Buraydah 52571, Saudi Arabia.
C3 Qassim University; Qassim University
RP Rahmani, AH (corresponding author), Qassim Univ, Coll Appl Med Sci, Dept Med Labs, Buraydah 52571, Saudi Arabia.
EM ah.rahmani@qu.edu.sa
RI Ahmad, Varish/AAP-9041-2020
OI Ali Khan, Amjad/0000-0001-6030-4493; Almatroodi, Saleh
   A./0000-0002-5260-0265; Alsahli, Mohammed A. A./0000-0001-9357-2216
FU Deputyship for Research & Innovation, Ministry of Education, Saudi
   Arabia [QU-IF-02-01-28388]
FX Deputyship for Research & Innovation, Ministry of Education, Saudi
   Arabia, project number (QU-IF-02-01-28388).
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NR 59
TC 33
Z9 34
U1 3
U2 17
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2218-1989
J9 METABOLITES
JI Metabolites
PD JAN
PY 2023
VL 13
IS 1
AR 130
DI 10.3390/metabo13010130
PG 16
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 8A7LL
UT WOS:000916416400001
PM 36677055
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Oyama, J
   Tanaka, A
   Sato, Y
   Tomiyama, H
   Sata, M
   Ishizu, T
   Taguchi, I
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   Yamada, H
   Maemura, K
   Ako, J
   Bando, YK
   Ueda, S
   Inoue, T
   Murohara, T
   Node, K
AF Oyama, Jun-ichi
   Tanaka, Atsushi
   Sato, Yasunori
   Tomiyama, Hirofumi
   Sata, Masataka
   Ishizu, Tomoko
   Taguchi, Isao
   Kuroyanagi, Takanori
   Teragawa, Hiroki
   Ishizaka, Nobukazu
   Kanzaki, Yumiko
   Ohishi, Mitsuru
   Eguchi, Kazuo
   Higashi, Yukihito
   Yamada, Hirotsugu
   Maemura, Koji
   Ako, Junya
   Bando, Yasuko K.
   Ueda, Shinichiro
   Inoue, Teruo
   Murohara, Toyoaki
   Node, Koichi
CA PRIZE Study Investigators
TI Rationale and design of a multicenter randomized study for evaluating
   vascular function under uric acid control using the xanthine oxidase
   inhibitor, febuxostat: the PRIZE study
SO CARDIOVASCULAR DIABETOLOGY
LA English
DT Article
DE Carotid artery; Febuxostat; Hyperuricemia; Intima-media thickness (IMT);
   Randomized controlled trial; Xanthine oxidase inhibitor
ID INTIMA-MEDIA THICKNESS; CHRONIC HEART-FAILURE; CARDIOVASCULAR
   RISK-FACTORS; CARDIAC-SURGERY PATIENTS; PARALLEL BETWEEN-GROUP; NU-FLASH
   TRIAL; CAROTID ATHEROSCLEROSIS; METABOLIC SYNDROME; FOLLOW-UP;
   DOUBLE-BLIND
AB Background: Xanthine oxidase inhibitors are anti-hyperuricemic drugs that decrease serum uric acid levels by inhibiting its synthesis. Xanthine oxidase is also recognized as a pivotal enzyme in the production of oxidative stress. Excess oxidative stress induces endothelial dysfunction and inflammatory reactions in vascular systems, leading to atherosclerosis. Many experimental studies have suggested that xanthine oxidase inhibitors have anti-atherosclerotic effects by decreasing in vitro and in vivo oxidative stress. However, there is only limited evidence on the clinical implications of xanthine oxidase inhibitors on atherosclerotic cardiovascular disease in patients with hyperuricemia. We designed the PRIZE study to evaluate the effects of febuxostat on a surrogate marker of cardiovascular disease risk, ultrasonography-based intima-media thickness of the carotid artery in patients with hyperuricemia.
   Methods: The study is a multicenter, prospective, randomized, open-label and blinded-endpoint evaluation (PROBE) design. A total of 500 patients with asymptomatic hyperuricemia (uric acid >7.0 mg/dL) and carotid intima-media thickness >= 1.1 mm will be randomized centrally to receive either febuxostat (10-60 mg/day) or non-pharmacological treatment. Randomization is carried out using the dynamic allocation method stratified according to age (<65, >= 65 year), gender, presence or absence of diabetes mellitus, serum uric acid (<8.0, >= 8.0 mg/dL), and carotid intima-media thickness (<1.3, >= 1.3 mm). In addition to administering the study drug, we will also direct lifestyle modification in all participants, including advice on control of body weight, sleep, exercise and healthy diet. Carotid intima-media thickness will be evaluated using ultrasonography performed by skilled technicians at a central laboratory. Follow-up will be continued for 24 months. The primary endpoint is percentage change in mean intima-media thickness of the common carotid artery 24 months after baseline, measured by carotid ultrasound imaging.
   Conclusions: PRIZE will be the first study to provide important data on the effects of febuxostat on atherosclerosis in patients with asymptomatic hyperuricemia.
C1 [Oyama, Jun-ichi; Tanaka, Atsushi; Node, Koichi] Saga Univ, Fac Med, Dept Cardiovasc Med, 5-1-1 Nabeshima, Saga 8498501, Japan.
   [Sato, Yasunori] Chiba Univ, Dept Clin Res, Grad Sch Med, Chiba, Japan.
   [Tomiyama, Hirofumi] Tokyo Med Univ, Dept Cardiol, Tokyo, Japan.
   [Sata, Masataka; Yamada, Hirotsugu] Univ Tokushima, Grad Sch, Dept Cardiovasc Med, Inst Biomed Sci, Tokushima, Japan.
   [Ishizu, Tomoko] Univ Tsukuba, Fac Med, Dept Clin Lab Med, Tsukuba, Ibaraki, Japan.
   [Taguchi, Isao; Kuroyanagi, Takanori] Dokkyo Med Univ, Koshigaya Hosp, Dept Cardiol, Koshigaya, Japan.
   [Teragawa, Hiroki] West Japan Railway Co, Hiroshima Gen Hosp, Dept Cardiovasc Med, Hiroshima, Japan.
   [Ishizaka, Nobukazu; Kanzaki, Yumiko] Osaka Med Coll, Dept Cardiol, Internal Med 3, Takatsuki, Osaka, Japan.
   [Ohishi, Mitsuru] Kagoshima Univ, Dept Cardiovasc Med & Hypertens, Kagoshima, Japan.
   [Eguchi, Kazuo] Jichi Med Univ, Sch Med, Dept Med, Div Cardiovasc Med, Shimotsuke, Japan.
   [Higashi, Yukihito] Hiroshima Univ, Dept Cardiovasc Regenerat & Med, Res Inst Radiat Biol & Med, Hiroshima, Japan.
   [Maemura, Koji] Nagasaki Univ, Grad Sch Biomed Sci, Dept Cardiovasc Med, Nagasaki, Japan.
   [Ako, Junya] Kitasato Univ, Dept Cardiovasc Med, Sagamihara, Kanagawa, Japan.
   [Bando, Yasuko K.; Murohara, Toyoaki] Nagoya Univ, Grad Sch Med, Dept Cardiol, Nagoya, Aichi, Japan.
   [Ueda, Shinichiro] Univ Ryukyus, Dept Clin Pharmacol & Therapeut, Nishihara, Okinawa, Japan.
   [Inoue, Teruo] Dokkyo Med Univ, Dept Cardiovasc Med, Mibu, Tochigi, Japan.
C3 Saga University; Chiba University; Tokyo Medical University; Tokushima
   University; University of Tsukuba; Dokkyo Medical University; The West
   Japan Railway Company; Osaka Medical & Pharmaceutical University;
   Kagoshima University; Jichi Medical University; Hiroshima University;
   Nagasaki University; Kitasato University; Nagoya University; University
   of the Ryukyus; Dokkyo Medical University
RP Node, K (corresponding author), Saga Univ, Fac Med, Dept Cardiovasc Med, 5-1-1 Nabeshima, Saga 8498501, Japan.
EM node@cc.saga-u.ac.jp
RI Higashi, Yukihito/G-5343-2019; Murohara, Toyoaki/M-4958-2014; Koba,
   Shinji/GZK-2961-2022; SATO, Yasunori/AGK-2994-2022; Teragawa,
   Hiroki/AAJ-5116-2020; Ishizu, Tomoko/IAO-5630-2023; Sata,
   Masataka/IST-9041-2023; Bando, Yasuko K/M-4831-2014
OI Yamada, Hirotsugu/0000-0003-3741-5560; Bando, Yasuko
   K/0000-0003-4166-6784
FU TEIJIN PHARMA LIMITED
FX This study was financially sponsored by TEIJIN PHARMA LIMITED. The
   funding body had no role in study design, data collection and analysis,
   and decision to publish or preparation of the manuscript.
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NR 70
TC 31
Z9 34
U1 0
U2 9
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1475-2840
J9 CARDIOVASC DIABETOL
JI Cardiovasc. Diabetol.
PD JUN 18
PY 2016
VL 15
AR 87
DI 10.1186/s12933-016-0409-2
PG 10
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism
GA DQ0GC
UT WOS:000378875800001
PM 27317093
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Li, GL
   Xie, FX
   Yan, SY
   Hu, XF
   Jin, B
   Wang, J
   Wu, JF
   Yin, DZ
   Xie, QJ
AF Li, Guolin
   Xie, Fuxia
   Yan, Siyu
   Hu, Xiaofei
   Jin, Bo
   Wang, Jun
   Wu, Jinfeng
   Yin, Dazhong
   Xie, Qingji
TI Subhealth: definition, criteria for diagnosis and potential prevalence
   in the central region of China
SO BMC PUBLIC HEALTH
LA English
DT Article
DE Subhealth; Health; Disease; Oxidative stress; Thiobarbituric
   acid-reactive substances (TBARS)
ID METABOLIC SYNDROME; DIABETES-MELLITUS; PHYSICAL-ACTIVITY; OXIDATIVE
   STRESS; LIFE-STYLE; ASSOCIATION; DIET; AMERICAN; RISK; INFLAMMATION
AB Background: A full evaluation of health conditions is necessary for the effective implementation of public health interventions. However, terms to address the intermediate state between health and disease are lacking, leading the public to overlook this state and thus increasing the risks of developing disease.
   Methods: A cross-sectional health survey of 1,473 randomly recruited Chinese Han adults of both sexes living in the central region of China. The criteria for diagnosis of subhealth was defined as the presence of >= 1 of the following abnormalities: body mass index >= 25 kg/m(2) or waist circumference >= 102 cm in men and 88 cm in women; systolic pressure 120-139 mmHg and/or diastolic pressure 80-89 mmHg; serum triglyceride level >= 150 mg/dL and/or total cholesterol level >= 200 mg/dL and/or high-density lipoprotein cholesterol level < 40 mg/dL in men and 50 mg/dL in women; serum glucose level 110-125 mg/dL; estimated glomerular filtration rate 60-89 ml/min/1.73 m(2); levels of liver enzymes in liver function tests between 41-59 U/L, or with fatty liver disease but < 33% of affected hepatocytes; levels of oxidative stress biomarkers beyond the reference range of 95%; or problems with both sleep quality and psychological state.
   Results: The prevalences of subhealth and disease in the central region of China were 36.6% and 43.1%, respectively. The prevalence of disease increased from 26.3% in participants aged 20-39 years, to 47.6% and 78.9% for participants aged 40-59 years and those aged 60 years or older, respectively. Compared with participants aged 20-39, the prevalences of health and subhealth in participants aged 60 years or older decreased by 86.7% and 60.3%, respectively. The prevalence of subhealth was increased in association with increases in lifestyle risk scores, while the prevalences of both health and disease were reduced.
   Conclusion: The prevalences of subhealth and disease are high in central China. Subhealth is associated with high lifestyle risk scores. Both the health care sector and the public should pay more attention to subhealth. Lifestyle modifications and/or psychological interventions are needed to ameliorate these conditions.
C1 [Li, Guolin; Xie, Fuxia; Yan, Siyu; Hu, Xiaofei; Wang, Jun; Wu, Jinfeng; Yin, Dazhong] Hunan Normal Univ, Coll Life Sci, Minist Educ, Key Lab Prot Chem & Dev Biol, Changsha 410081, Hunan, Peoples R China.
   [Yin, Dazhong] Jinan Univ, Qingyuan City Peoples Hosp, Qingyuan 511518, Guangdong, Peoples R China.
   [Li, Guolin; Xie, Qingji] Hunan Normal Univ, Coll Chem & Chem Engn, Minist Educ, Key Lab Chem Biol & Tradit Chinese Med Res, Changsha 410081, Hunan, Peoples R China.
   [Jin, Bo] Hunan Normal Univ, Affiliated Hosp, Hosp Changsha 4, Changsha 410081, Hunan, Peoples R China.
C3 Ministry of Education - China; Hunan Normal University; Jinan
   University; Hunan Normal University; Ministry of Education - China;
   Hunan Normal University
RP Li, GL (corresponding author), Hunan Normal Univ, Coll Life Sci, Minist Educ, Key Lab Prot Chem & Dev Biol, Changsha 410081, Hunan, Peoples R China.
EM hnsdlgl@hunnu.edu.cn; dazhongyin002@126.com
RI wu, jinfeng/GSD-8333-2022; hu, xiaofei/IQX-0675-2023; Li,
   Guolin/F-6502-2016
FU National 863 Grants of China [2008AA02Z411]; National Natural Science
   Funds of China [30800207, 31271257]; Science and Technology Project of
   Hunan Province
FX The authors are very grateful to the International Science Editing for
   language editing, and would like to thank the participants of the study.
   This study was supported by National 863 Grants of China,
   (2008AA02Z411), National Natural Science Funds of China (30800207,
   31271257), and Science and Technology Project of Hunan Province. The
   funding sponsors had no role in design, in the collection, analysis, and
   interpretation of data; in the writing of the manuscript; and in the
   decision to submit the manuscript for publication.
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NR 44
TC 42
Z9 44
U1 3
U2 38
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2458
J9 BMC PUBLIC HEALTH
JI BMC Public Health
PD MAY 4
PY 2013
VL 13
AR 446
DI 10.1186/1471-2458-13-446
PG 8
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA 145YY
UT WOS:000319057200001
PM 23642312
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Mattioli, LF
   Thomas, JH
   Holloway, NB
   Schropp, KP
   Wood, JG
AF Mattioli, Leone F.
   Thomas, James H.
   Holloway, Naomi B.
   Schropp, Kurt P.
   Wood, John G.
TI Effects of Intragastric Fructose and Dextrose on Mesenteric
   Microvascular Inflammation and Postprandial Hyperemia in the Rat
SO JOURNAL OF PARENTERAL AND ENTERAL NUTRITION
LA English
DT Article
DE intragastric fructose; leukocyte adherence; reactive oxygen species;
   microvascular inflammation; alpha-lipoic acid; postprandial hyperemia
ID ALPHA-LIPOIC ACID; BLOOD-FLOW; METABOLIC SYNDROME; SYSTEMIC HYPOXIA;
   OXIDATIVE STRESS; PRETERM INFANTS; URIC-ACID; CELLS; CONSUMPTION;
   ADHERENCE
AB Objectives: Fructose superfused on the mesenteric venules of rats induces microvascular inflammation via oxidative stress. It is unknown whether intragastric fructose exerts a similar effect and whether fructose impairs postprandial hyperemia (PPH). The goals were to determine whether intragastric fructose administration promotes leukocyte adherence and whether fructose, owing to its oxidative properties, may also impair nitric oxide-dependent PPH in the mesenteric microcirculation of rats. Methods: Leukocyte adherence to mesenteric venules, arteriolar velocity, and diameter were measured in Sprague-Dawley rats before and 30 minutes after intragastric (1 mL 0.5 M, similar to 0.3 g/kg) dextrose (n = 5), fructose (n = 6), and fructose after intravenous injection of the antioxidant alpha-lipoic acid (ALA, n = 6). Results: Only fructose increased leukocyte adherence: control 2.3 +/- 0.3 per 100 mu m; fructose 9.7 +/- 1.4 per 100 mu m (P < .001). This effect was independent of changes in venular shear rate: control 269 +/- 48 s(-1); fructose 181 +/- 27 s(-1) (P > .05, r(2) = 0.083 for shear rate vs leukocyte adherence). Dextrose had no effect on leukocyte adherence: control 1.52 +/- 0.13 per 100 mu m; dextrose 2.0 +/- 0.7 per 100 mu m (P > .05). ALA prevented fructoseinduced leukocyte adherence: control 1.9 +/- 0.2 per 100 mu m; fructose + ALA 1.8 +/- 0.3 per 100 mu m (P > .05). Neither fructose nor dextrose induced PPH: arteriolar velocity: control 3.3 +/- 0.49 cm/s, fructose 3.06 +/- 0.34 cm/s (P > .05); control 3.3 +/- 1.0 cm/s, dextrose 3.15 +/- 1.1 cm/s (P > .05); arteriolar diameter: control 19.9 +/- 1.10 mu m, fructose 19.7 +/- 1.0 mu m (P > .05); control 21.5 +/- 2.6, dextrose 20.0 +/- 2.7 mu m (P > .05). Conclusions: Intragastric fructose induced leukocyte adherence via oxidative stress. Neither dextrose nor fructose induced PPH, likely because of the inhibitory effect of anesthesia on splanchnic vasomotor tone. (JPEN J Parenter Enteral Nutr. 2011;35:223-228)
C1 [Mattioli, Leone F.] Univ Kansas, Med Ctr, Dept Pediat, Div Pediat Cardiol, Kansas City, KS 66160 USA.
   [Thomas, James H.; Holloway, Naomi B.; Schropp, Kurt P.; Wood, John G.] Univ Kansas, Med Ctr, Dept Surg, Kansas City, KS 66160 USA.
   [Wood, John G.] Univ Kansas, Med Ctr, Dept Mol & Integrat Physiol, Kansas City, KS 66160 USA.
C3 University of Kansas; University of Kansas Medical Center; University of
   Kansas; University of Kansas Medical Center; University of Kansas;
   University of Kansas Medical Center
RP Mattioli, LF (corresponding author), Univ Kansas, Med Ctr, Dept Pediat, Div Pediat Cardiol, Kansas City, KS 66160 USA.
EM lmattiol@kumc.edu
CR Alemany CA, 1997, AM J PHYSIOL-GASTR L, V272, pG612, DOI 10.1152/ajpgi.1997.272.3.G612
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NR 28
TC 2
Z9 2
U1 0
U2 0
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0148-6071
EI 1941-2444
J9 JPEN-PARENTER ENTER
JI J. Parenter. Enter. Nutr.
PD MAR
PY 2011
VL 35
IS 2
BP 223
EP 228
DI 10.1177/0148607110385819
PG 6
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 751QO
UT WOS:000289632900011
PM 21378252
OA Bronze
DA 2025-06-11
ER

PT J
AU Rendo-Urteaga, T
   Puchau, B
   Chueca, M
   Oyarzabal, M
   Azcona-Sanjulián, MC
   Martínez, JA
   Marti, A
AF Rendo-Urteaga, T.
   Puchau, B.
   Chueca, M.
   Oyarzabal, M.
   Azcona-Sanjulian, M. C.
   Martinez, J. A.
   Marti, A.
TI Total antioxidant capacity and oxidative stress after a 10-week dietary
   intervention program in obese children
SO EUROPEAN JOURNAL OF PEDIATRICS
LA English
DT Article
DE Obese children; Oxidative stress; Antioxidant capacity; Obesity;
   Intervention; Isoprostane
ID FOOD-FREQUENCY QUESTIONNAIRE; CARDIOVASCULAR RISK-FACTORS; HEALTHY-YOUNG
   ADULTS; WEIGHT-LOSS PROGRAM; IN-VITRO ASSAYS; METABOLIC SYNDROME;
   INSULIN-RESISTANCE; SCHOOL-CHILDREN; SPANISH COHORT; ADOLESCENTS
AB Dietary and serum total antioxidant capacity (TAC) are considered appropriate tools for investigating the potential health effects of dietary antioxidants consumed in mixed diets. The aim was to analyze the impact of a dietary intervention on macronutrient intakes and to evaluate the improvement on oxidative status after weight loss (WL) by measuring dietary and serum TAC, and urinary F2-isoprostane levels as markers of oxidative stress. Forty-four overweight/obese children (mean age 11.5 years) were enrolled to undergo a 10-week WL program. They were dichotomized at the median of body mass index-standard deviation score (BMI-SDS) change, as high (HR) and low responders (LR) after intervention. Subjects were prescribed with a fixed full-day meal diet, calculated according to their basal metabolic rate and physical activity levels. A validated food-frequency questionnaire was used to retrospectively calculate TAC and daily nutrient intake. The HR subjects were able to reduce anthropometric indices and to improve lipid and glucose profile. They also significantly diminished fat intake (p = 0.013). Moreover, baseline serum TAC values did significantly predict the reduction in urinary F2 isoprostane (B = -0.236 (-0.393 to -0.078); p = 0.014) in the HR group after the WL program. Notably, changes in dietary TAC after the treatment were associated with a decrease in body weight after the 10-week intervention (B = -2.815 (-5.313 to -0.318), p = 0.029) in the HR group. The -Delta SerumTAC/Delta DietaryTAC and the -Delta F2Isoprostane/Delta DietaryTAC ratios revealed that the relationships between oxidative markers and antioxidants dietary intake were more favorable in the HR than in the LR group. Conclusion: Our study showed that a 10-week WL program was able to reduce adiposity indices in obese children. Moreover, after the intervention changes in dietary TAC and WL were significantly associated. Our result suggests that specific food with a high TAC content (such as fruits, vegetables, and legumes) could be recommended to improve WL.
C1 [Rendo-Urteaga, T.; Puchau, B.; Martinez, J. A.; Marti, A.] Univ Navarra, Dept Nutr Food Sci & Physiol, Navarra 31008, Spain.
   [Chueca, M.; Oyarzabal, M.] Complejo Hosp Navarra, Pediat Endocrinol Unit, Pamplona, Spain.
   [Azcona-Sanjulian, M. C.] Univ Navarra Clin, Pediat Endocrinol Unit, Dept Pediat, Pamplona, Spain.
   [Martinez, J. A.; Marti, A.] Inst Hlth Carlos III, CIBERobn, Madrid, Spain.
C3 University of Navarra; Servicio Navarro de Salud - Osasunbidea;
   University of Navarra; CIBER - Centro de Investigacion Biomedica en Red;
   CIBEROBN
RP Marti, A (corresponding author), Univ Navarra, Dept Nutr Food Sci & Physiol, C Irunlarrea S-N, Navarra 31008, Spain.
EM amarti@unav.es
RI Marti del Moral, Amelia/H-1192-2017; Azcona, Cristina/A-1160-2015;
   Rendo-Urteaga, Tara/I-3321-2015; Martinez Hernandez, J
   Alfredo/K-8709-2014
OI Marti del Moral, Amelia/0000-0001-9832-7981; Azcona,
   Cristina/0000-0001-5534-8758; Rendo-Urteaga, Tara/0000-0002-8597-3535;
   Martinez Hernandez, J Alfredo/0000-0001-5218-6941
FU Navarra Government; Linea Especial; Nutricion y Obesidad (University of
   Navarra); Carlos III Health Institute (CIBER project) [CB06/03/1017];
   Departamento de Salud [PI 54/2009]
FX We thank the children and their parents for their participation in this
   study. Research relating to this article was funded by grants from the
   Navarra Government, Departamento de Salud (grant PI 54/2009), Linea
   Especial, Nutricion y Obesidad (University of Navarra), Carlos III
   Health Institute (CIBER project, CB06/03/1017). The scholarships to T.
   Rendo-Urteaga from the Asociacion de Amigos de la Universidad de Navarra
   is fully acknowledged. The proofreading of the final version by
   Massimiliano Marinoni is gratefully acknowledged.
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NR 54
TC 21
Z9 22
U1 0
U2 27
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0340-6199
EI 1432-1076
J9 EUR J PEDIATR
JI Eur. J. Pediatr.
PD MAY
PY 2014
VL 173
IS 5
BP 609
EP 616
DI 10.1007/s00431-013-2229-7
PG 8
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA AG1AF
UT WOS:000335146500008
PM 24310523
DA 2025-06-11
ER

PT J
AU Cao, H
   Chen, XS
   Wang, ZJ
   Wang, L
   Xia, Q
   Zhang, W
AF Cao, Hui
   Chen, Xiaosong
   Wang, Zhijun
   Wang, Lei
   Xia, Qiang
   Zhang, Wei
TI The role of MDM2-p53 axis dysfunction in the hepatocellular carcinoma
   transformation
SO CELL DEATH DISCOVERY
LA English
DT Review
ID URSODEOXYCHOLIC ACID; VIRUS-REPLICATION; TUMOR SUPPRESSION;
   DOWN-REGULATION; CELL-CYCLE; P53; LIVER; APOPTOSIS; PROMOTES; PATHWAY
AB Liver cancer is the second most frequent cause of cancer-related death globally. The main histological subtype is hepatocellular carcinoma (HCC), which is derived from hepatocytes. According to the epidemiologic studies, the most important risk factors of HCC are chronic viral infections (HBV, HCV, and HIV) and metabolic disease (metabolic syndrome). Interestingly, these carcinogenic factors that contributed to HCC are associated with MDM2-p53 axis dysfunction, which presented with inactivation of p53 and overactivation of MDM2 (a transcriptional target and negative regulator of p53). Mechanically, the homeostasis of MDM2-p53 feedback loop plays an important role in controlling the initiation and progression of HCC, which has been found to be dysregulated in HCC tissues. To maintain long-term survival in hepatocytes, hepatitis viruses have lots of ways to destroy the defense strategies of hepatocytes by inducingTP53mutation and silencing, promotingMDM2overexpression, accelerating p53 degradation, and stabilizing MDM2. As a result, genetic instability, chronic ER stress, oxidative stress, energy metabolism switch, and abnormalities in antitumor genes can be induced, all of which might promote hepatocytes' transformation into hepatoma cells. In addition, abnormal proliferative hepatocytes and precancerous cells cannot be killed, because of hepatitis viruses-mediated exhaustion of Kupffer cells and hepatic stellate cells (HSCs) and CD4(+)T cells by disrupting their MDM2-p53 axis. Moreover, inefficiency of hepatic immune response can be further aggravated when hepatitis viruses co-infected with HIV. Unlike with chronic viral infections, MDM2-p53 axis might play a dual role in glucolipid metabolism of hepatocytes, which presented with enhancing glucolipid catabolism, but promoting hepatocyte injury at the early and late stages of glucolipid metabolism disorder. Oxidative stress, fatty degeneration, and abnormal cell growth can be detected in hepatocytes that were suffering from glucolipid metabolism disorder, and all of which could contribute to HCC initiation. In this review, we focus on the current studies of the MDM2-p53 axis in HCC, and specifically discuss the impact of MDM2-p53 axis dysfunction by viral infection and metabolic disease in the transformation of normal hepatocytes into hepatoma cells. We also discuss the therapeutic avenues and potential targets that are being developed to normalize the MDM2-p53 axis in HCC.
C1 [Cao, Hui; Wang, Lei; Zhang, Wei] Shanghai Univ Tradit Chinese Med, Longhua Hosp, Dept Liver Dis, Shanghai 200030, Peoples R China.
   [Chen, Xiaosong; Xia, Qiang] Shanghai Jiao Tong Univ, Sch Med, Renji Hosp, Dept Liver Surg, Shanghai 200127, Peoples R China.
   [Wang, Zhijun] Tongji Univ, Dept Tradit Chinese Med, Putuo Peoples Hosp, Shanghai, Peoples R China.
C3 Shanghai University of Traditional Chinese Medicine; Shanghai Jiao Tong
   University; Tongji University
RP Zhang, W (corresponding author), Shanghai Univ Tradit Chinese Med, Longhua Hosp, Dept Liver Dis, Shanghai 200030, Peoples R China.; Xia, Q (corresponding author), Shanghai Jiao Tong Univ, Sch Med, Renji Hosp, Dept Liver Surg, Shanghai 200127, Peoples R China.
EM xiaqiang@medmail.com.cn; zhangwei@longhua.net
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NR 165
TC 59
Z9 62
U1 1
U2 19
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
EI 2058-7716
J9 CELL DEATH DISCOV
JI Cell Death Discov.
PD JUN 19
PY 2020
VL 6
IS 1
AR 53
DI 10.1038/s41420-020-0287-y
PG 14
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA LZ4ZB
UT WOS:000541233100001
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Logue, MW
   Miller, MW
   Wolf, EJ
   Huber, BR
   Morrison, FG
   Zhou, ZW
   Zheng, YC
   Smith, AK
   Daskalakis, NP
   Ratanatharathorn, A
   Uddin, M
   Nievergelt, CM
   Ashley-Koch, AE
   Baker, DG
   Beckham, JC
   Garrett, ME
   Boks, MP
   Geuze, E
   Grant, GA
   Hauser, MA
   Kessler, RC
   Kimbrel, NA
   Maihofer, AX
   Marx, CE
   Qin, XJ
   Risbrough, VB
   Rutten, BPF
   Stein, MB
   Ursano, RJ
   Vermetten, E
   Vinkers, CH
   Ware, EB
   Stone, A
   Schichman, SA
   McGlinchey, RE
   Milberg, WP
   Hayes, JP
   Verfaellie, M
AF Logue, Mark W.
   Miller, Mark W.
   Wolf, Erika J.
   Huber, Bertrand Russ
   Morrison, Filomene G.
   Zhou, Zhenwei
   Zheng, Yuanchao
   Smith, Alicia K.
   Daskalakis, Nikolaos P.
   Ratanatharathorn, Andrew
   Uddin, Monica
   Nievergelt, Caroline M.
   Ashley-Koch, Allison E.
   Baker, Dewleen G.
   Beckham, Jean C.
   Garrett, Melanie E.
   Boks, Marco P.
   Geuze, Elbert
   Grant, Gerald A.
   Hauser, Michael A.
   Kessler, Ronald C.
   Kimbrel, Nathan A.
   Maihofer, Adam X.
   Marx, Christine E.
   Qin, Xue-Jun
   Risbrough, Victoria B.
   Rutten, Bart P. F.
   Stein, Murray B.
   Ursano, Robert J.
   Vermetten, Eric
   Vinkers, Christiaan H.
   Ware, Erin B.
   Stone, Annjanette
   Schichman, Steven A.
   McGlinchey, Regina E.
   Milberg, William P.
   Hayes, Jasmeet P.
   Verfaellie, Mieke
CA Traumatic Stress Brain Study Grp
TI An epigenome-wide association study of posttraumatic stress disorder in
   US veterans implicates several new DNA methylation loci
SO CLINICAL EPIGENETICS
LA English
DT Article
ID METABOLIC SYNDROME; PERIPHERAL-BLOOD; CONTROLLED-TRIAL; GENE-EXPRESSION;
   PTSD; SMOKING; EXPOSURE; CORTEX; AGE; EPIGENETICS
AB Background Previous studies using candidate gene and genome-wide approaches have identified epigenetic changes in DNA methylation (DNAm) associated with posttraumatic stress disorder (PTSD). Methods In this study, we performed an EWAS of PTSD in a cohort of Veterans (n = 378 lifetime PTSD cases and 135 controls) from the Translational Research Center for TBI and Stress Disorders (TRACTS) cohort assessed using the Illumina EPIC Methylation BeadChip which assesses DNAm at more than 850,000 sites throughout the genome. Our model included covariates for ancestry, cell heterogeneity, sex, age, and a smoking score based on DNAm at 39 smoking-associated CpGs. We also examined in EPIC-based DNAm data generated from pre-frontal cortex (PFC) tissue from the National PTSD Brain Bank (n = 72). Results The analysis of blood samples yielded one genome-wide significant association with PTSD at cg19534438 in the gene G0S2 (p = 1.19 x 10(-7), p(adj) = 0.048). This association was replicated in an independent PGC-PTSD-EWAS consortium meta-analysis of military cohorts (p = 0.0024). We also observed association with the smoking-related locus cg05575921 in AHRR despite inclusion of a methylation-based smoking score covariate (p = 9.16 x 10(-6)), which replicates a previously observed PGC-PTSD-EWAS association (Smith et al. 2019), and yields evidence consistent with a smoking-independent effect. The top 100 EWAS loci were then examined in the PFC data. One of the blood-based PTSD loci, cg04130728 in CHST11, which was in the top 10 loci in blood, but which was not genome-wide significant, was significantly associated with PTSD in brain tissue (in blood p = 1.19 x 10(-5), p(adj) = 0.60, in brain, p = 0.00032 with the same direction of effect). Gene set enrichment analysis of the top 500 EWAS loci yielded several significant overlapping GO terms involved in pathogen response, including "Response to lipopolysaccharide" (p = 6.97 x 10(-6), p(adj) = 0.042). Conclusions The cross replication observed in independent cohorts is evidence that DNA methylation in peripheral tissue can yield consistent and replicable PTSD associations, and our results also suggest that that some PTSD associations observed in peripheral tissue may mirror associations in the brain.
C1 [Logue, Mark W.; Miller, Mark W.; Wolf, Erika J.; Huber, Bertrand Russ; Morrison, Filomene G.; Hayes, Jasmeet P.] VA Boston Healthcare Syst, Natl Ctr PTSD, Boston, MA 02130 USA.
   [Logue, Mark W.; Miller, Mark W.; Wolf, Erika J.; Huber, Bertrand Russ; Morrison, Filomene G.; Hayes, Jasmeet P.; Verfaellie, Mieke] Boston Univ, Sch Med, Dept Psychiat, Boston, MA 02118 USA.
   [Logue, Mark W.] Boston Univ, Sch Med, Biomed Genet, Boston, MA 02118 USA.
   [Logue, Mark W.; Zhou, Zhenwei; Zheng, Yuanchao] Boston Univ, Dept Biostat, Sch Publ Hlth, Boston, MA 02215 USA.
   [Smith, Alicia K.] Emory Univ, Dept Gynecol & Obstet, Atlanta, GA 30322 USA.
   [Smith, Alicia K.] Emory Univ, Dept Psychiat & Behav Sci, Atlanta, GA 30322 USA.
   [Daskalakis, Nikolaos P.; McGlinchey, Regina E.; Milberg, William P.] Harvard Med Sch, Dept Psychiat, Boston, MA 02115 USA.
   [Daskalakis, Nikolaos P.] McLean Hosp, 115 Mill St, Belmont, MA 02178 USA.
   [Daskalakis, Nikolaos P.] Cohen Vet Biosci, Cambridge, MA USA.
   [Daskalakis, Nikolaos P.] Icahn Sch Med Mt Sinai, Dept Psychiat, New York, NY 10029 USA.
   [Ratanatharathorn, Andrew] Columbia Univ, Dept Epidemiol, New York, NY USA.
   [Uddin, Monica] Univ S Florida, Coll Publ Hlth, Genom Program, Tampa, FL 33620 USA.
   [Uddin, Monica] Univ S Florida, Coll Publ Hlth, Global Hlth & Infect Dis Res Program, Tampa, FL 33620 USA.
   [Nievergelt, Caroline M.; Baker, Dewleen G.; Maihofer, Adam X.; Risbrough, Victoria B.; Stein, Murray B.] Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA.
   [Nievergelt, Caroline M.; Baker, Dewleen G.; Maihofer, Adam X.; Risbrough, Victoria B.] Vet Affairs San Diego Healthcare Syst, Ctr Excellence Stress & Mental Hlth, San Diego, CA USA.
   [Nievergelt, Caroline M.; Maihofer, Adam X.; Risbrough, Victoria B.] Vet Affairs San Diego Healthcare Syst, Res Serv, San Diego, CA USA.
   [Ashley-Koch, Allison E.; Garrett, Melanie E.; Hauser, Michael A.; Qin, Xue-Jun] Duke Univ, Med Ctr, Duke Mol Physiol Inst, Durham, NC USA.
   [Baker, Dewleen G.; Stein, Murray B.] Vet Affairs San Diego Healthcare Syst, Psychiat Serv, San Diego, CA USA.
   [Beckham, Jean C.] Duke Univ, Dept Psychiat & Behav Sci, Durham, NC USA.
   [Beckham, Jean C.; Kimbrel, Nathan A.] Durham VA Med Ctr, Res, Durham, NC USA.
   [Beckham, Jean C.; Kimbrel, Nathan A.] VA Midatlantic Mental Illness Res Educ & Clin Ctr, Genet Res Lab, Durham, NC USA.
   [Boks, Marco P.; Geuze, Elbert] UMC Utrecht Brain Ctr, Dept Psychiat, Utrecht, Netherlands.
   [Geuze, Elbert] Netherlands Minist Def, Brain Res & Innovat Ctr, Utrecht, Netherlands.
   [Grant, Gerald A.] Stanford Univ, Med Ctr, Dept Neurosurg, Stanford, CA 94305 USA.
   [Kessler, Ronald C.] Harvard Med Sch, Dept Hlth Care Policy, Boston, MA 02115 USA.
   [Kimbrel, Nathan A.] Duke Univ, Duke Mol Physiol Inst, Durham, NC USA.
   [Marx, Christine E.] Univ Pittsburgh, Dept Crit Care Med Neurol & Neurosurg, Pittsburgh, PA USA.
   [Marx, Christine E.] Duke Univ, Dept Psychiat & Behav Sci, Med Ctr, Durham, NC USA.
   [Rutten, Bart P. F.] Maastricht Univ, Sch Mental Hlth & Neurosci, Dept Psychiat & Neuropsychol, Med Ctr, Maastricht, Netherlands.
   [Stein, Murray B.] Vet Affairs San Diego Healthcare Syst, Mill Vet Program, San Diego, CA USA.
   [Ursano, Robert J.] Uniformed Serv Univ Hlth Sci, Dept Psychiat, Bethesda, MD USA.
   [Vermetten, Eric] Arq, Psychotrauma Reseach Expert Grp, Diemen, NH, Netherlands.
   [Vermetten, Eric] Leiden Univ, Dept Psychiat, Med Ctr, Leiden, ZH, Netherlands.
   [Vermetten, Eric] Res Ctr, Netherlands Def Dept, Utrecht, UT, Netherlands.
   [Vermetten, Eric] NYU, Dept Psychiat, Sch Med, 550 1St Ave, New York, NY 10016 USA.
   [Vinkers, Christiaan H.] Amsterdam UMC Locat VUmc, Dept Anat & Neurosci, Holland, Netherlands.
   [Vinkers, Christiaan H.] Amsterdam UMC Locat VUmc, Dept Psychiat, Holland, Netherlands.
   [Ware, Erin B.] Univ Michigan, Survey Res Ctr, Inst Social Res, Ann Arbor, MI 48109 USA.
   [Stone, Annjanette; Schichman, Steven A.] Cent Arkansas Vet Healthcare Syst, Res Serv, Pharmacogen Anal Lab, Little Rock, AR USA.
   [McGlinchey, Regina E.; Milberg, William P.] VA Boston Hlth Care Syst, Geriatr Res Educ & Clin Ctr, Boston, MA USA.
   [McGlinchey, Regina E.; Milberg, William P.] VA Boston Hlth Care Syst, Translat Res Ctr TBI & Stress Disorders, Boston, MA USA.
   [Hayes, Jasmeet P.] Ohio State Univ, Dept Psychol, Columbus, OH 43210 USA.
   [Hayes, Jasmeet P.] Ohio State Univ, Chron Brain Injury Program, Columbus, OH 43210 USA.
   [Verfaellie, Mieke] Memory Disorders Res Ctr, VA Boston Healthcare Syst, Boston, MA USA.
   [Verfaellie, Mieke] Boston Univ, Sch Med, Boston, MA 02118 USA.
C3 Harvard University; Harvard University Medical Affiliates; US Department
   of Veterans Affairs; Veterans Health Administration (VHA); VA Boston
   Healthcare System; Boston University; Boston University; Boston
   University; Emory University; Emory University; Harvard University;
   Harvard Medical School; Harvard University; Harvard University Medical
   Affiliates; McLean Hospital; Icahn School of Medicine at Mount Sinai;
   Columbia University; State University System of Florida; University of
   South Florida; State University System of Florida; University of South
   Florida; University of California System; University of California San
   Diego; US Department of Veterans Affairs; Veterans Health Administration
   (VHA); VA San Diego Healthcare System; US Department of Veterans
   Affairs; Veterans Health Administration (VHA); VA San Diego Healthcare
   System; Duke University; US Department of Veterans Affairs; Veterans
   Health Administration (VHA); VA San Diego Healthcare System; Duke
   University; US Department of Veterans Affairs; Veterans Health
   Administration (VHA); Durham VA Medical Center; Stanford University;
   Harvard University; Harvard Medical School; Duke University;
   Pennsylvania Commonwealth System of Higher Education (PCSHE); University
   of Pittsburgh; Duke University; Maastricht University; US Department of
   Veterans Affairs; Veterans Health Administration (VHA); VA San Diego
   Healthcare System; Uniformed Services University of the Health Sciences
   - USA; Arq Psychotrauma Expert Group; Leiden University - Excl LUMC;
   Leiden University; Leiden University Medical Center (LUMC); New York
   University; University of Michigan System; University of Michigan; US
   Department of Veterans Affairs; Veterans Health Administration (VHA);
   Central Arkansas Veterans Healthcare System; Geriatric Research
   Education & Clinical Center; Harvard University; Harvard University
   Medical Affiliates; US Department of Veterans Affairs; Veterans Health
   Administration (VHA); VA Boston Healthcare System; Harvard University;
   Harvard University Medical Affiliates; US Department of Veterans
   Affairs; Veterans Health Administration (VHA); VA Boston Healthcare
   System; University System of Ohio; Ohio State University; University
   System of Ohio; Ohio State University; Harvard University; Harvard
   University Medical Affiliates; US Department of Veterans Affairs;
   Veterans Health Administration (VHA); VA Boston Healthcare System;
   Boston University
RP Logue, MW (corresponding author), VA Boston Healthcare Syst, Natl Ctr PTSD, Boston, MA 02130 USA.; Logue, MW (corresponding author), Boston Univ, Sch Med, Dept Psychiat, Boston, MA 02118 USA.; Logue, MW (corresponding author), Boston Univ, Sch Med, Biomed Genet, Boston, MA 02118 USA.; Logue, MW (corresponding author), Boston Univ, Dept Biostat, Sch Publ Hlth, Boston, MA 02215 USA.
EM loguem@bu.edu
RI Bloch, Michael/O-7845-2017; Vinkers, Christiaan/AAV-1720-2020;
   McGlinchey, Regina/R-1971-2016; Kessler, Ronald/A-2741-2012; Miller,
   Mark/G-7322-2011; Ursano, Robert/ABE-6533-2020; Hayes,
   Jasmeet/AAN-4150-2020; Risbrough, Victoria/X-3344-2019; Kimbrel,
   Nathan/P-3109-2016; Zhou, Zhenwei/AGB-0315-2022; Geuze,
   Elbert/AET-0833-2022; Vermetten, Eric/B-1335-2008; Keane,
   Terence/I-8253-2014; Daskalakis, Nikolaos/B-7930-2014
OI Vinkers, Christiaan/0000-0003-3698-0744; Vermetten,
   Eric/0000-0003-0579-4404; Keane, Terence/0000-0002-0482-3149; Marx,
   Brian/0000-0001-8988-1796; Rutten, Bart/0000-0002-9834-6346; Daskalakis,
   Nikolaos/0000-0003-1660-9112; Scott, William/0000-0001-9336-6404; Logue,
   Mark/0000-0001-9347-7892; Davis, David/0000-0002-9323-6180; Williamson,
   Douglas/0000-0002-5310-1716
FU Department of Veterans Affairs BLRD grant [I01BX003477]; Translational
   Research Center for TBI and Stress Disorders (TRACTS), a Department of
   Veterans Affairs Rehabilitation Research and Development (RRAMP;D)
   Traumatic Brain Injury Center of Excellence at VA Boston Healthcare
   System [B3001-C]; Cooperative Studies Program, Research and Development,
   Department of Veterans Affairs; VA Health Research and Development
   (HSRD); Department of the Army; National Institutes of Health, National
   Institute of Mental Health (NIH/NIMH) [U01MH087981]; Department of
   Defense (USUHS) [HU0001-15-2-0004]; Dutch Ministry of Defence; VENI
   Award fellowship from the Netherlands Organisation for Scientific
   Research (NWO) [916.11.086]; US Department of Defense [W81XWH08-2-0159];
   Clinical Sciences Research and Development (CSRAMP;D) Research Career
   Scientist Award from the US Department of Veterans Affairs (VA) [IK2
   CX000525]; Biomedical and Laboratory Research and Development (BLRAMP;D)
   Merit Award from the US Department of Veterans Affairs (VA); VA
   Mid-Atlantic Mental Illness Research, Education and Clinical Center
   (MIRECC); Durham Veterans Affairs Medical Center; VA Office of Mental
   Health Services; VA Office of Research and Development; National Center
   for PTSD: Behavioral Sciences Division; Marine Corps; Navy Bureau of
   Medicine and Surgery (BUMED); NIH [R01MH093500];  [1R03AG051877]; 
   [1R21AG061367-01];  [1I01CX00127601A2];  [5T32MH019836-18]; 
   [R21MH102834];  [1R01MH108826]
FX This work was funded by I01BX003477, a Department of Veterans Affairs
   BLR&D grant to MWL, 1R03AG051877, 1R21AG061367-01, and 1I01CX00127601A2
   to EJW, 5T32MH019836-18 to FGM, R21MH102834 to MWM, 1R01MH108826 to
   Smith/Logue/Nievergelt/Uddin, the National Center for PTSD: Behavioral
   Sciences Division, and the Translational Research Center for TBI and
   Stress Disorders (TRACTS), a Department of Veterans Affairs
   Rehabilitation Research and Development (RR&D) Traumatic Brain Injury
   Center of Excellence (B3001-C) at VA Boston Healthcare System. Genotype
   and methylation data for the TRACTS and Brain Bank Cohort was generated
   with the support of resources and of facilities at the Pharmacogenomics
   Analysis Laboratory (Research Service, Central Arkansas Veterans
   Healthcare System, Little Rock, Arkansas), a core research laboratory
   funded by the Cooperative Studies Program, Research and Development,
   Department of Veterans Affairs. Marine Resiliency Study (MRS) funding
   from The Marine Corps, Navy Bureau of Medicine and Surgery (BUMED) and
   VA Health Research and Development (HSR&D) who provided funding for MRS
   data collection and analysis (PI DGB) and NIH R01MH093500 which funded
   the GWAS assays and analysis (PI CMN). Army STARRS was sponsored by the
   Department of the Army and funded under cooperative agreement number
   U01MH087981 (2009-2015) with the National Institutes of Health, National
   Institute of Mental Health (NIH/NIMH). Subsequently, STARRS-LS was
   sponsored and funded by the Department of Defense (USUHS grant no.
   HU0001-15-2-0004). Data collection of PRISMO was funded by the Dutch
   Ministry of Defence, and DNA methylation analyses in PRISMO were funded
   by the VENI Award fellowship from the Netherlands Organisation for
   Scientific Research (NWO, grant no. 916.11.086). The PTSD and TBI Injury
   and Traumatic Stress Clinical Consortium (INTRuST) was funded by a grant
   from the US Department of Defense (PI: Stein, MB): W81XWH08-2-0159.
   Mid-Atlantic Mental Illness Research Education and Clinical Center the
   study of Post-Deployment Mental Health Study funding included a Clinical
   Sciences Research and Development (CSR&D) Research Career Scientist
   Award (#11SRCS-009) to Dr. Beckham, a CSR&D Career Development Award
   (#IK2 CX000525) to Dr. Kimbrel, and Biomedical and Laboratory Research
   and Development (BLR&D) Merit Award to Dr. Beckham from the US
   Department of Veterans Affairs (VA). This work was also supported by the
   VA Mid-Atlantic Mental Illness Research, Education and Clinical Center
   (MIRECC), the Durham Veterans Affairs Medical Center, the VA Office of
   Mental Health Services, and the VA Office of Research and Development.
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NR 70
TC 53
Z9 57
U1 1
U2 12
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1868-7075
EI 1868-7083
J9 CLIN EPIGENETICS
JI Clin. Epigenetics
PD MAR 14
PY 2020
VL 12
IS 1
AR 46
DI 10.1186/s13148-020-0820-0
PG 14
WC Oncology; Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Oncology; Genetics & Heredity
GA KW2AJ
UT WOS:000520971800001
PM 32171335
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Szic, KSV
   Declerck, K
   Vidakovic, M
   Berghe, WV
AF Szic, Katarzyna Szarc vel
   Declerck, Ken
   Vidakovic, Melita
   Berghe, Wim Vanden
TI From inflammaging to healthy aging by dietary lifestyle choices: is
   epigenetics the key to personalized nutrition?
SO CLINICAL EPIGENETICS
LA English
DT Review
DE Phytochemicals; Oxidative stress; Inflammation; Aging; Epigenetics;
   Metabolism; Personalized nutrition
ID DNA METHYLATION PATTERNS; EPIGENOME-WIDE ASSOCIATION; NATURAL-PRODUCTS;
   CANCER CHEMOPREVENTION; DEVELOPMENTAL ORIGINS; CALORIC RESTRICTION;
   GENE-EXPRESSION; STEM-CELLS; COAT COLOR; IN-UTERO
AB The progressively older population in developed countries is reflected in an increase in the number of people suffering from age-related chronic inflammatory diseases such as metabolic syndrome, diabetes, heart and lung diseases, cancer, osteoporosis, arthritis, and dementia. The heterogeneity in biological aging, chronological age, and aging-associated disorders in humans have been ascribed to different genetic and environmental factors (i.e., diet, pollution, stress) that are closely linked to socioeconomic factors. The common denominator of these factors is the inflammatory response. Chronic low-grade systemic inflammation during physiological aging and immunosenescence are intertwined in the pathogenesis of premature aging also defined as 'inflammaging.' The latter has been associated with frailty, morbidity, and mortality in elderly subjects. However, it is unknown to what extent inflammaging or longevity is controlled by epigenetic events in early life. Today, human diet is believed to have a major influence on both the development and prevention of age-related diseases. Most plant-derived dietary phytochemicals and macro-and micronutrients modulate oxidative stress and inflammatory signaling and regulate metabolic pathways and bioenergetics that can be translated into stable epigenetic patterns of gene expression. Therefore, diet interventions designed for healthy aging have become a hot topic in nutritional epigenomic research. Increasing evidence has revealed that complex interactions between food components and histone modifications, DNA methylation, non-coding RNA expression, and chromatin remodeling factors influence the inflammaging phenotype and as such may protect or predispose an individual to many age-related diseases. Remarkably, humans present a broad range of responses to similar dietary challenges due to both genetic and epigenetic modulations of the expression of target proteins and key genes involved in the metabolism and distribution of the dietary constituents. Here, we will summarize the epigenetic actions of dietary components, including phytochemicals, and macro-and micronutrients as well as metabolites, that can attenuate inflammaging. We will discuss the challenges facing personalized nutrition to translate highly variable interindividual epigenetic diet responses to potential individual health benefits/risks related to aging disease.
C1 [Szic, Katarzyna Szarc vel; Declerck, Ken; Berghe, Wim Vanden] Univ Antwerp, Dept Biomed Sci, Lab Prot Sci Prote & Epigenet Signaling, B-2610 Antwerp, Belgium.
   [Vidakovic, Melita] Univ Belgrade, Inst Biol Res, Dept Mol Biol, Belgrade 11060, Serbia.
C3 University of Antwerp; University of Belgrade
RP Berghe, WV (corresponding author), Univ Antwerp, Dept Biomed Sci, Lab Prot Sci Prote & Epigenet Signaling, Campus Drie Eiken,Univ Plein 1, B-2610 Antwerp, Belgium.
EM wim.vandenberghe@uantwerpen.be
RI Vanden Berghe, Wim/S-6425-2018; Vidakovic, Melita/G-6747-2016
OI Vanden Berghe, Wim/0000-0003-0161-7355; Declerck,
   Ken/0000-0001-8104-8054; Vidakovic, Melita/0000-0001-8410-6264
FU COST : Epigenetics from bench to bedside [TD0905]; COST : Epigenetic
   Chemical Biology [CM1406]; COST : Interindividual variation in response
   to consumption of plant food bioactives [FA1403]; FWO; Serbian Ministry
   of Education, Science and Technological Development [173020,
   451-03-3455/2013-09/12/02]
FX This work has been supported by COST TD0905: Epigenetics from bench to
   bedside; COST CM1406: Epigenetic Chemical Biology; COST FA1403:
   Interindividual variation in response to consumption of plant food
   bioactives, and FWO research grants. MV wishes to recognize the
   assistance of the Serbian Ministry of Education, Science and
   Technological Development, Grant 173020 and bilateral project 'Pavle
   Savic' (451-03-3455/2013-09/12/02). We thank all lab members for helpful
   discussions.
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NR 339
TC 136
Z9 146
U1 2
U2 109
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1868-7075
EI 1868-7083
J9 CLIN EPIGENETICS
JI Clin. Epigenetics
PD MAR 25
PY 2015
VL 7
AR 33
DI 10.1186/s13148-015-0068-2
PG 18
WC Oncology; Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Genetics & Heredity
GA CF0TP
UT WOS:000352257400001
PM 25861393
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU El Menyiy, N
   Aboulaghras, S
   Bakrim, S
   Moubachir, R
   Taha, D
   Khalid, A
   Abdalla, AN
   Algarni, AS
   Hermansyah, A
   Ming, LC
   Rusu, ME
   Bouyahya, A
AF El Menyiy, Naoual
   Aboulaghras, Sara
   Bakrim, Saad
   Moubachir, Rania
   Taha, Doaue
   Khalid, Asaad
   Abdalla, Ashraf N.
   Algarni, Alanood S.
   Hermansyah, Andi
   Ming, Long Chiau
   Rusu, Marius Emil
   Bouyahya, Abdelhakim
TI Genkwanin: An emerging natural compound with multifaceted
   pharmacological effects
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Review
DE Genkwanin; Bioactive compounds; Antioxidants; Oxidative stress;
   Inflammation; Anticancer; Infectious diseases; Communicable diseases
ID LARGE-SCALE PREPARATION; GINKGO-BILOBA EXTRACT; NF-KAPPA-B; IN-VITRO;
   ROSMARINUS-OFFICINALIS; DAPHNE-GENKWA; LIQUID-CHROMATOGRAPHY;
   PHENOLIC-COMPOUNDS; MASS-SPECTROMETRY; ANTIOXIDANT ACTIVITIES
AB Plant bioactive molecules could play key preventive and therapeutic roles in chronological aging and the pathogenesis of many chronic diseases, often accompanied by increased oxidative stress and low-grade inflammation. Dietary antioxidants, including genkwanin, could decrease oxidative stress and the expression of pro-inflammatory cytokines or pathways. The present study is the first comprehensive review of genkwanin, a methoxyflavone found in several plant species. Indeed, natural sources, and pharmacokinetics of genkwanin, the biological properties were discussed and highlighted in detail. This review analyzed and considered all original studies related to identification, isolation, quantification, investigation of the biological and pharmacological properties of genkwanin. We consulted all published papers in peer-reviewed journals in the English language from the inception of each database to 12 May 2023. Different phytochemical demonstrated that genkwanin is a non-glycosylated flavone found and isolated from several medicinal plants such as Genkwa Flos, Rosmarinus officinalis, Salvia officinalis, and Leonurus sibiricus. In vitro and in vivo biological and pharmacological investigations showed that Genkwanin exhibits remarkable antioxidant and anti-inflammatory activities, genkwanin, via activation of glucokinase, has shown antihyperglycemic activity with a potential role against metabolic syndrome and diabetes. Additionally, it revealed cardioprotective and neuroprotective properties, thus reducing the risk of cardiovascular diseases and assisting against neurodegenerative diseases. Furthermore, genkwanin showed other biological properties like antitumor capability, antibacterial, antiviral, and dermatoprotective effects. The involved mechanisms include sub-cellular, cellular and molecular actions at different levels such as inducing apoptosis and inhibiting the growth and proliferation of cancer cells. Despite the findings from preclinical studies that have demonstrated the effects of genkwanin and its diverse mechanisms of action, additional research is required to comprehensively explore its therapeutic potential. Primarily, extensive studies should be carried out to enhance our understanding of the molecule's pharmacodynamic actions and pharmacokinetic pathways. Moreover, toxicological and clinical investigations should be undertaken to assess the safety and clinical efficacy of genkwanin. These forthcoming studies are of utmost importance in fully unlocking the potential of this molecule in the realm of therapeutic applications.
C1 [El Menyiy, Naoual] Natl Agcy Med & Aromat Plants, Lab Pharmacol, Taounate 34025, Morocco.
   [Aboulaghras, Sara; Bouyahya, Abdelhakim] Mohammed V Univ Rabat, Fac Sci, Lab Human Pathol Biol, Rabat 10106, Morocco.
   [Bakrim, Saad] Ibn Zohr Univ, Polydisciplinary Fac Taroudant, Geobioenvironm Engn & Innovat Lab, Mol Engn Biotechnol & Innovat Team, Agadir 80000, Morocco.
   [Moubachir, Rania] Moulay Ismail Univ, Fac Sci, Bioact & Environm Hlth Lab, Meknes, Morocco.
   [Taha, Doaue] Mohammed V Univ Rabat, Fac Sci, Mol Modeling Mat Nanomat Water & Environm Lab, Dept Chem,CERNE2D, Rabat 10106, Morocco.
   [Khalid, Asaad] Jazan Univ, Subst Abuse & Toxicol Res Ctr, POB 114, Jazan 45142, Saudi Arabia.
   [Abdalla, Ashraf N.; Algarni, Alanood S.] Umm Al Qura Univ, Coll Pharm, Dept Pharmacol & Toxicol, Mecca 21955, Saudi Arabia.
   [Hermansyah, Andi; Ming, Long Chiau] Univ Airlangga, Fac Pharm, Dept Pharm Practice, Surabaya 60115, Indonesia.
   [Ming, Long Chiau] Sunway Univ, Sch Med & Life Sci, Sunway City, Malaysia.
   [Ming, Long Chiau] Univ Brunei Darussalam, PAPRSB Inst Hlth Sci, Gadong, Brunei.
   [Rusu, Marius Emil] Iuliu Hatieganu Univ Med & Pharm, Fac Pharm, Dept Pharmaceut Technol & Biopharmaceut, 8 Victor Babes, Cluj Napoca 400012, Romania.
C3 Mohammed V University in Rabat; Ibn Zohr University of Agadir; Moulay
   Ismail University of Meknes; Mohammed V University in Rabat; Jazan
   University; Umm Al-Qura University; Airlangga University; Sunway
   University; University Brunei Darussalam; Iuliu Hatieganu University of
   Medicine & Pharmacy
RP Bouyahya, A (corresponding author), Mohammed V Univ Rabat, Fac Sci, Lab Human Pathol Biol, Rabat 10106, Morocco.; Khalid, A (corresponding author), Jazan Univ, Subst Abuse & Toxicol Res Ctr, POB 114, Jazan 45142, Saudi Arabia.; Hermansyah, A (corresponding author), Univ Airlangga, Fac Pharm, Dept Pharm Practice, Surabaya 60115, Indonesia.; Rusu, ME (corresponding author), Iuliu Hatieganu Univ Med & Pharm, Fac Pharm, Dept Pharmaceut Technol & Biopharmaceut, 8 Victor Babes, Cluj Napoca 400012, Romania.
EM naoualelmenyiy@gmail.com; sara.aboulghras@gmail.com; s.bakrim@uiz.ac.ma;
   r.moubachir@fs.umi.ac.ma; douae.taha02@gmail.com; akahmed@jazanu.edu.sa;
   anabdrabo@uqu.edu.sa; aagarni@uqu.edu.sa; andi-h@ff.unair.ac.id;
   longchiauming@gmail.com; rusu.marius@umfcluj.ro; a.bouyahya@um5r.ac.ma
RI BAKRIM, SAAD/HPC-6347-2023; Algarni, Alanood/ISS-3317-2023; Abdalla,
   Ashraf/AAO-3313-2020; Rusu, Marius/E-3958-2017; Abdelhakim,
   BOUYAHYA/Y-5725-2019; KHALID, ASAAD/HJH-6413-2023; Ming, Long
   Chiau/J-5210-2015; Hermansyah, Andi/AAC-1494-2020
OI ABOULAGHRAS, SARA/0009-0004-3298-8145; Ahmed, Asaad
   Khalid/0000-0001-8734-2588; Rusu, Marius Emil/0000-0002-0880-9889; Ming,
   Long Chiau/0000-0002-6971-1383; Hermansyah, Andi/0000-0002-9716-3126
FU Deputyship for Research and Innovation, Ministry of Education in Saudi
   Arabia [ISP22-15]
FX Funding The authors extend their thanks to the Deputyship for Research
   and Innovation, Ministry of Education in Saudi Arabia for funding this
   research through the project number (ISP22-15) .
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NR 155
TC 23
Z9 23
U1 4
U2 27
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD SEP
PY 2023
VL 165
AR 115159
DI 10.1016/j.biopha.2023.115159
EA JUL 2023
PG 16
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA P4YD1
UT WOS:001050725500001
PM 37481929
OA gold
DA 2025-06-11
ER

PT J
AU Asare, GA
   Andam, SE
   Asare-Anane, H
   Ammanquah, S
   Anang-Quartey, Y
   Afriyie, DK
   Musah, I
AF Asare, George Awuku
   Andam, Sabina Ekua
   Asare-Anane, Henry
   Ammanquah, Seth
   Anang-Quartey, Yvonne
   Afriyie, Daniel K.
   Musah, Iddis
TI Lipid associated antioxidants: arylesterase and paraoxonase-1 in benign
   prostatic hyperplasia treatment-naive patients
SO PROSTATE INTERNATIONAL
LA English
DT Article
DE Arylesterase; Benign Prostatic Hyperplasia; Lipid Peroxidation;
   Paraoxonase 1
ID DENSITY-LIPOPROTEIN OXIDATION; METABOLIC SYNDROME; RISK; CANCER; PON1;
   CHOLESTEROL; SUSCEPTIBILITY; POLYMORPHISM; STRESS; ENERGY
AB Background: Oxidative stress and antioxidants have been implicated in many diseases including prostate cancer and benign prostatic hyperplasia (BPH). Lipid peroxidation contributes to oxidative stress. However, new and emerging antioxidants such as paraoxonase 1 (PON1) and arylesterase (ARE) associated with lipoprotein peroxidation have not been examined in BPH patients. PON1 and ARE, a high-density lipoprotein (HDL) cholesterol-bound enzyme system of antioxidants, protect low-density lipoprotein (LDL) cholesterol and HDL from oxidation by hydrolysis. The study primarily determined paraoxonase (PON1) and ARE activities in BPH treatment-naive patients.
   Materials and methods: Sixty newly diagnosed patients (treatment-naive) alongside 30 apparently healthy controls were recruited. Blood examinations included lipid profile (total cholesterol, triglycerides, LDL, HDL), glutathione peroxidase, PON1, ARE, and prostate specific antigen (PSA).
   Prostate volume and International Prostate Symptoms Score (IPSS) were determined.
   Results: PSA was significantly different between patient and control groups (P < 0.0001). Total cholesterol, triglycerides, and LDL were significantly higher in the patient group (P = 0.002, P < 0.001, P = 0.003, respectively). Glutathione peroxidase was very low in the patient group compared to the control group (5.65 +/- 2.30 ng/mL and 17.43 +/- 10.98 ng/mL, respectively). Although PON1 was higher in the patient group (50.22 +/- 19.68/61.30 +/- 29.55 ng/mL; P > 0.05), ARE was significantly lower in the patient group (61.31 +/- 21.76/49.30 +/- 19.82 ng/mL; P = 0.0098). No correlation was established between antioxidants and the lipid profile except for the LDL and PON1 patient group (r = 0.1486, P = 0.0374). Similarly, a weak correlation was also established between PSA and LDL in the patient group (r = -0.275, P = 0.033). PON1/HDL ratio was not significantly different. However, the ARE/HDL ratio was significantly lower in the patient group (P < 0.0001).
   Conclusion: These results signify the presence of a higher lipoprotein peroxidation activity and lower lipid-associated antioxidant activity in the patient group. The ARE/HDL ratio is a better indicator of the HDL associated antioxidant than the PON1/HDL ratio or the individual antioxidants (PON1 and ARE) as reported by others. (c) 2017 Asian Pacific Prostate Society, Published by Elsevier Korea LLC.
C1 [Asare, George Awuku; Anang-Quartey, Yvonne] Univ Ghana, Dept Med Lab Sci, Sch Biomed & Allied Hlth Sci, Korle Bu Campus, Korle Bu, Ghana.
   [Andam, Sabina Ekua; Asare-Anane, Henry; Ammanquah, Seth] Univ Ghana, Dept Chem Pathol, Sch Biomed & Allied Hlth Sci, Korle Bu Campus, Korle Bu, Ghana.
   [Afriyie, Daniel K.] Ghana Police Hosp, Dept Pharm, Cantonments, Ghana.
   [Musah, Iddis] Ghana Police Hosp, Dept Urol, Cantonments, Ghana.
C3 University of Ghana; University of Ghana
RP Asare, GA (corresponding author), Univ Ghana, Chem Pathol Unit, Dept Med Lab Sci, Sch Biomed & Allied Hlth Sci, POB KB 143,Korle Bu Campus, Korle Bu, Ghana.
EM gasare@chs.edu.gh
OI Anang, Yvonne/0009-0001-5236-8910
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NR 35
TC 13
Z9 14
U1 0
U2 5
PU ELSEVIER INC
PI SAN DIEGO
PA 525 B STREET, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 2287-8882
EI 2287-903X
J9 PROSTATE INT
JI Prostate Int.
PD MAR
PY 2018
VL 6
IS 1
BP 36
EP 40
DI 10.1016/j.prnil.2017.04.002
PG 5
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA FY3KU
UT WOS:000426719500007
PM 29556488
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Csibi, A
   Communi, D
   Müller, N
   Bottari, SP
AF Csibi, Alfredo
   Communi, David
   Mueller, Nathalie
   Bottari, Serge P.
TI Angiotensin II Inhibits Insulin-Stimulated GLUT4 Translocation and Akt
   Activation through Tyrosine Nitration-Dependent Mechanisms
SO PLOS ONE
LA English
DT Article
ID NITRIC-OXIDE SYNTHASE; TYPE-2 DIABETES-MELLITUS; OXIDATIVE STRESS;
   SKELETAL-MUSCLE; METABOLIC SYNDROME; PROTEIN-KINASES; HIGH-RISK;
   SENSITIVITY; RECEPTOR; PEROXYNITRITE
AB Angiotensin II (Ang II) plays a major role in the pathogenesis of insulin resistance and diabetes by inhibiting insulin's metabolic and potentiating its trophic effects. Whereas the precise mechanisms involved remain ill-defined, they appear to be associated with and dependent upon increased oxidative stress. We found Ang II to block insulin-dependent GLUT4 translocation in L6 myotubes in an NO- and O-2(center dot-)-dependent fashion suggesting the involvement of peroxynitrite. This hypothesis was confirmed by the ability of Ang II to induce tyrosine nitration of the MAP kinases ERK1/2 and of protein kinase B/Akt (Akt). Tyrosine nitration of ERK1/2 was required for their phosphorylation on Thr and Tyr and their subsequent activation, whereas it completely inhibited Akt phosphorylation on Ser(473) and Thr(308) as well as its activity. The inhibitory effect of nitration on Akt activity was confirmed by the ability of SIN-1 to completely block GSK3 alpha phosphorylation in vitro. Inhibition of nitric oxide synthase and NAD(P)Hoxidase and scavenging of free radicals with myricetin restored insulin-stimulated Akt phosphorylation and GLUT4 translocation in the presence of Ang II. Similar restoration was obtained by inhibiting the ERK activating kinase MEK, indicating that these kinases regulate Akt activation. We found a conserved nitration site of ERK1/2 to be located in their kinase domain on Tyr(156/139), close to their active site Asp(166/149), in agreement with a permissive function of nitration for their activation. Taken together, our data show that Ang II inhibits insulin-mediated GLUT4 translocation in this skeletal muscle model through at least two pathways: first through the transient activation of ERK1/2 which inhibit IRS-1/2 and second through a direct inhibitory nitration of Akt. These observations indicate that not only oxidative but also nitrative stress play a key role in the pathogenesis of insulin resistance. They underline the role of protein nitration as a major mechanism in the regulation of Ang II and insulin signaling pathways and more particularly as a key regulator of protein kinase activity.
C1 [Csibi, Alfredo; Mueller, Nathalie; Bottari, Serge P.] Grenoble Univ, INSERM, Lab Bioenerget Fondamentale & Appliquee, U884, Grenoble, France.
   [Communi, David] Univ Libre Bruxelles, IRIBHM, Brussels, Belgium.
   [Bottari, Serge P.] CHU Grenoble, F-38043 Grenoble, France.
C3 Communaute Universite Grenoble Alpes; Universite Grenoble Alpes (UGA);
   Institut National de la Sante et de la Recherche Medicale (Inserm);
   Universite Libre de Bruxelles; CHU Grenoble Alpes; Communaute Universite
   Grenoble Alpes; Universite Grenoble Alpes (UGA)
RP Csibi, A (corresponding author), Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA.
EM Serge.Bottari@ujf-grenoble.fr
RI Bottari, Serge/ABF-3990-2021
OI Bottari, Serge P./0000-0002-4172-2400
FU AGIR
FX This work was partly supported by AGIR a dom, grant: "Nitration and
   insulin resistance" (www.agiradom.com). The funders had no role in study
   design, data collection and analysis, decision to publish, or
   preparation of the manuscript.
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NR 69
TC 56
Z9 61
U1 0
U2 8
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD APR 7
PY 2010
VL 5
IS 3
AR e10070
DI 10.1371/journal.pone.0010070
PG 13
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 580MX
UT WOS:000276454000020
PM 20383279
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Díaz, CM
   Bullon, B
   Ruiz-Salmerón, RJ
   Fernández-Riejos, P
   Fernández-Palacín, A
   Battino, M
   Cordero, MD
   Quiles, JL
   Varela-López, A
   Bullón, P
AF Diaz, Carmen M.
   Bullon, Beatriz
   Ruiz-Salmeron, Rafael J.
   Fernandez-Riejos, Patricia
   Fernandez-Palacin, Ana
   Battino, Maurizio
   Cordero, Mario D.
   Quiles, Jose L.
   Varela-Lopez, Alfonso
   Bullon, Pedro
TI Molecular inflammation and oxidative stress are shared mechanisms
   involved in both myocardial infarction and periodontitis
SO JOURNAL OF PERIODONTAL RESEARCH
LA English
DT Article
DE autophagy; interleukin-1beta; lipid peroxidation
ID GINGIVAL CREVICULAR FLUID; REACTIVE OXYGEN; NLRP3 INFLAMMASOME;
   LIPID-PEROXIDATION; ANTIOXIDANT STATUS; METABOLIC SYNDROME;
   BLOOD-PRESSURE; NADPH OXIDASE; GLOBAL BURDEN; AUTOPHAGY
AB Background and Objective Our aims were to improve the understanding of the pathogenic relationship between cardiovascular diseases and periodontitis and to generate new perspectives in the prevention and treatment of acute myocardial infarction (AMI) and periodontitis. The present study evaluates possible differences in inflammation, oxidative stress, and autophagy markers among subject suffering AMI, periodontitis, or both, to explore possible common pathogenic mechanisms.
   Material and Methods A total of 260 subjects were enrolled in the study: 106 subjects that survived to a first AMI (AMI group) and 154 subjects had no cardiac events in their clinical record (control group). A questionnaire was used to assess age, height, weight, blood pressure, and heart rate. The clinical probing depth, clinical attachment loss, number of remaining teeth, and average number of sites with bleeding on probing were assessed. Lipid peroxidation and protein levels of phosphorylated AMP-activated protein kinase (p-AMPK) and microtubule-associated proteins 1A/1B-light chain 3-II (LC3-II) were determined in isolated peripheral blood mononuclear cells by thiobarbituric acid reactive substances (TBARS) assay and Western blot, respectively. Plasma levels of interleukin-1 beta were determined using a commercial ELISA kit. All the obtained variables were compared between subjects suffering an AMI with or without periodontitis and control subject periodontal healthy or with periodontitis.
   Results A higher proportion of subjects suffering AMI + periodontitis than only AMI (without periodontitis) was found. Higher levels of TBARS were found in subjects with periodontitis than in subjects without periodontitis in both AMI and control subjects. Positive correlations between IL-1 beta levels and TBARS and between IL-1 beta levels and LC3-II were found only in control subjects.
   Conclusion Results from the present study are consistent with the suggestion of periodontitis as a potential risk factor for AMI. Periodontitis association with circulating lipid peroxides in both AMI and control subjects were found. The absence of differences in IL-1 beta levels between AMI subjects (only AMI vs AMI + periodontitis) suggests that oxidative stress could be the main pathogenic link between AMI and periodontitis.
C1 [Diaz, Carmen M.; Bullon, Beatriz; Bullon, Pedro] Univ Seville, Dept Oral Med & Periodontol, C Avicena S-N, E-41009 Seville, Spain.
   [Ruiz-Salmeron, Rafael J.] Virgen Macarena Univ Hosp, Heart Ctr, Seville, Spain.
   [Fernandez-Riejos, Patricia] Virgen Macarena Univ Hosp, Dept Clin Biochem, Seville, Spain.
   [Fernandez-Palacin, Ana] Univ Seville, Sch Med, Dept Stat, Seville, Spain.
   [Battino, Maurizio] Univ Politecn Marche, Dipartimento Sci Clin Specialist & Odontostomatol, Sez Biochim, Ancona, Italy.
   [Battino, Maurizio] Univ Vigo, Dept Analyt & Food Chem, Nutr & Food Sci Grp, CITACA,CACTI, Vigo, Spain.
   [Battino, Maurizio] Jiangsu Univ, Int Res Ctr Food Nutr & Safety, Zhenjiang, Jiangsu, Peoples R China.
   [Cordero, Mario D.; Quiles, Jose L.; Varela-Lopez, Alfonso] Univ Granada, Biomed Res Ctr, Inst Nutr & Food Technol Jose Mataix Verdu, Dept Physiol, Granada, Spain.
   [Quiles, Jose L.] Northwest Univ, Coll Food Sci & Technol, Xian, Peoples R China.
C3 University of Sevilla; Hospital Universitario Virgen Macarena; Hospital
   Universitario Virgen Macarena; University of Sevilla; Marche Polytechnic
   University; Universidade de Vigo; Jiangsu University; University of
   Granada; Northwest University Xi'an
RP Bullón, P (corresponding author), Univ Seville, Dept Oral Med & Periodontol, C Avicena S-N, E-41009 Seville, Spain.
EM pbullon@us.es
RI Battino, Maurizio/E-6103-2012; Varela-López, Alfonso/F-8055-2016;
   Cordero, Mario/L-8006-2014; Fernandez-Palacin, Ana/M-9635-2018; Bullon,
   Pedro/E-6319-2010; Quiles, Jose L./C-6911-2013
OI Fernandez-Palacin, Ana/0000-0002-5823-5705; Bullon,
   Pedro/0000-0003-4873-4196; Quiles, Jose L./0000-0002-9048-9086
FU Grupo de Investigacion Junta de Andalucia [CTS113]
FX Grupo de Investigacion Junta de Andalucia CTS113, Grant/Award Number:
   CTS113
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NR 62
TC 30
Z9 34
U1 1
U2 19
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-3484
EI 1600-0765
J9 J PERIODONTAL RES
JI J. Periodont. Res.
PD AUG
PY 2020
VL 55
IS 4
BP 519
EP 528
DI 10.1111/jre.12739
EA FEB 2020
PG 10
WC Dentistry, Oral Surgery & Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dentistry, Oral Surgery & Medicine
GA MS1RX
UT WOS:000516705000001
PM 32106337
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Ruan, J
   Hu, XH
   Liu, YH
   Han, Z
   Ruan, QW
AF Ruan, Jian
   Hu, Xiuhua
   Liu, Yuehong
   Han, Zhao
   Ruan, Qingwei
TI Vulnerability to chronic stress and the phenotypic heterogeneity of
   presbycusis with subjective tinnitus
SO FRONTIERS IN NEUROSCIENCE
LA English
DT Review
DE presbycusis; tinnitus; heterogeneity; chronic stress; allostatic load;
   frailty phenotype; comorbidity
ID DORSAL COCHLEAR NUCLEUS; HEARING-LOSS; BEHAVIORAL EVIDENCE; LIFE-COURSE;
   INFERIOR COLLICULUS; METABOLIC SYNDROME; AUDITORY THALAMUS; BRAIN
   RESERVE; OLDER-ADULTS; NOISE
AB Age-related functional reserve decline and vulnerability of multiple physiological systems and organs, as well as at the cellular and molecular levels, result in different frailty phenotypes, such as physical, cognitive, and psychosocial frailty, and multiple comorbidities, including age-related hearing loss (ARHL) and/or tinnitus due to the decline in auditory reserve. However, the contributions of chronic non-audiogenic cumulative exposure, and chronic audiogenic stress to phenotypic heterogeneity of presbycusis and/or tinnitus remain elusive. Because of the cumulative environmental stressors throughout life, allostasis systems, the hypothalamus-pituitary-adrenal (HPA) and the sympathetic adrenal-medullary (SAM) axes become dysregulated and less able to maintain homeostasis, which leads to allostatic load and maladaptation. Brain-body communication via the neuroendocrine system promotes systemic chronic inflammation, overmobilization of energetic substances (glucose and lipids), and neuroplastic changes via the non-genomic and genomic actions of glucocorticoids, catecholamines, and their receptors. These systemic maladaptive alterations might lead to different frailty phenotypes and physical, cognitive, and psychological comorbidities, which, in turn, cause and exacerbate ARHL and/or tinnitus with phenotypic heterogeneity. Chronic audiogenic stressors, including aging accompanying ontological diseases, cumulative noise exposure, and ototoxic drugs as well as tinnitus, activate the HPA axis and SAM directly and indirectly by the amygdala, promoting allostatic load and maladaptive neuroplasticity in the auditory system and other vulnerable brain regions, such as the hippocampus, amygdala, and medial prefrontal cortex (mPFC). In the auditory system, peripheral deafferentation, central disinhibition, and tonotopic map reorganization may trigger tinnitus. Cross-modal maladaptive neuroplasticity between the auditory and other sensory systems is involved in tinnitus modulation. Persistent dendritic growth and formation, reduction in GABAergic inhibitory synaptic inputs induced by chronic audiogenic stresses in the amygdala, and increased dendritic atrophy in the hippocampus and mPFC, might involve the enhancement of attentional processing and long-term memory storage of chronic subjective tinnitus, accompanied by cognitive impairments and emotional comorbidities. Therefore, presbycusis and tinnitus are multisystem disorders with phenotypic heterogeneity. Stressors play a critical role in the phenotypic heterogeneity of presbycusis. Differential diagnosis based on biomarkers of metabonomics study, and interventions tailored to different ARHL phenotypes and/or tinnitus will contribute to healthy aging and improvement in the quality of life.
C1 [Ruan, Jian; Liu, Yuehong; Han, Zhao] Fudan Univ, Huadong Hosp, Shanghai Med Coll, Dept Otolaryngol, Shanghai, Peoples R China.
   [Hu, Xiuhua; Ruan, Qingwei] Fudan Univ, Huadong Hosp, Shanghai Inst Geriatr & Gerontol, Lab Aging Antiaging & Cognit Performance, Shanghai, Peoples R China.
   [Hu, Xiuhua; Ruan, Qingwei] Fudan Univ, Huadong Hosp, Shanghai Med Coll, Res Ctr Aging & Med,Shanghai Key Lab Clin Geriatr, Shanghai, Peoples R China.
C3 Fudan University; Fudan University; Fudan University
RP Ruan, QW (corresponding author), Fudan Univ, Huadong Hosp, Shanghai Inst Geriatr & Gerontol, Lab Aging Antiaging & Cognit Performance, Shanghai, Peoples R China.; Ruan, QW (corresponding author), Fudan Univ, Huadong Hosp, Shanghai Med Coll, Res Ctr Aging & Med,Shanghai Key Lab Clin Geriatr, Shanghai, Peoples R China.
EM 13661717346@163.com
RI Hu, Xiuhua/HQY-8396-2023; han, zhao/KEH-5275-2024; ruan,
   qingwei/IUN-3847-2023
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NR 159
TC 7
Z9 7
U1 1
U2 13
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1662-453X
J9 FRONT NEUROSCI-SWITZ
JI Front. Neurosci.
PD DEC 21
PY 2022
VL 16
AR 1046095
DI 10.3389/fnins.2022.1046095
PG 16
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 7M5PO
UT WOS:000906709200001
PM 36620444
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Rodrigo, N
   Chen, H
   Pollock, CA
   Glastras, SJ
AF Rodrigo, Natassia
   Chen, Hui
   Pollock, Carol A.
   Glastras, Sarah J.
TI Kidney outcomes are altered by preconception weight modulation in rodent
   mothers with obesity
SO SCIENTIFIC REPORTS
LA English
DT Article
DE Kidney disease; Reproductive health; Liraglutide; Diet; Weight loss
ID GLUCAGON-LIKE PEPTIDE-1; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   OXIDATIVE STRESS; MATERNAL OBESITY; DISEASE; HYPERTENSION; DYSFUNCTION;
   MECHANISMS; PREGNANCY
AB Obesity increases the risk of chronic kidney disease. We have previously demonstrated the benefits of preconception maternal weight loss on fertility and pregnancy outcomes in a mouse model of maternal obesity. Here, we elucidate if preconception weight loss, either by diet modification or the glucose-like peptide 1 agonist liraglutide, used in the treatment of diabetes and obesity, improves maternal kidney outcomes in late gestation. C57BL/6 female mice were fed either a high-fat-diet (HFD) or a chow (control) diet for 8 weeks. To induce pre-pregnancy weight loss, HFD-fed dams were switched to chow diet (HFD-C) or administered liraglutide (0.3 mg/kg subcutaneous) whilst continuing on HFD (HFD-L). Liraglutide was discontinued one week prior to mating. HFD-V mice continued on HFD, with saline injections. A group of HFD-fed dams were 'diet switched' to chow after conception (post-conception, HFD-PC). Maternal body weight and glucose tolerance were measured: (1) preconception and (2) during late gestation followed by blood, urine and kidney collection. Serum creatinine, urinary creatinine and albumin, kidney tissue gene expression and protein were measured. In the preconception period, HFD-L and HFD-C mothers have lower urine albumin:creatinine ratios (UACR) and fatty acid synthase (FAS) protein expression (P < 0.005 vs. HFD-V). At late gestation, kidneys of HFD-V and HFD-PC dams have increased gene expression of insulin receptor and FAS (P < 0.05) and higher UACR compared to controls (P < 0.01). In the HFD-PC group, kidneys show increased mRNA and protein expression of metabolic and oxidative stress markers (FAS, 8-OHdG vs. control, P < 0.05, P < 0.0001 respectively). The preconception intervention groups with liraglutide, or diet change show reduced oxidative stress (protein expression of 8-OHdG, P < 0.05 vs. HFD), mRNA and protein expression of FAS (P < 0.05 vs. HFD), protein expression of fibrosis markers (collagen IV, fibronectin vs. HFD, P < 0.05), and UACR (P < 0.05 vs. HFD). This study suggests that preconception weight loss benefits maternal kidney health during pregnancy, superior to diet intervention once already pregnant.
C1 [Rodrigo, Natassia; Pollock, Carol A.; Glastras, Sarah J.] Kolling Inst Med Res, Renal Res Lab, St Leonards, NSW, Australia.
   [Rodrigo, Natassia; Pollock, Carol A.; Glastras, Sarah J.] Univ Sydney, Sydney Med Sch, North Precinct, Sydney, NSW, Australia.
   [Rodrigo, Natassia; Glastras, Sarah J.] Royal North Shore Hosp, Dept Diabet Endocrinol & Metab, Reserve Rd, St Leonards, NSW, Australia.
   [Rodrigo, Natassia] Nepean Hosp, Dept Diabet & Endocrinol, Kingswood, NSW, Australia.
   [Chen, Hui] Univ Technol Sydney, Fac Sci, Sch Life Sci, Ultimo, NSW, Australia.
C3 University of Sydney; Kolling Institute of Medical Research; University
   of Sydney; Royal North Shore Hospital; Nepean Hospital; University of
   Technology Sydney
RP Rodrigo, N (corresponding author), Kolling Inst Med Res, Renal Res Lab, St Leonards, NSW, Australia.; Rodrigo, N (corresponding author), Univ Sydney, Sydney Med Sch, North Precinct, Sydney, NSW, Australia.; Rodrigo, N (corresponding author), Royal North Shore Hosp, Dept Diabet Endocrinol & Metab, Reserve Rd, St Leonards, NSW, Australia.; Rodrigo, N (corresponding author), Nepean Hosp, Dept Diabet & Endocrinol, Kingswood, NSW, Australia.
EM natassia.rodrigo@sydney.edu.au
RI Pollock, Carol/H-1117-2015; Glastras, Sarah/AAL-2541-2020; Chen,
   Hui/D-2005-2014
OI Chen, Hui/0000-0001-6883-3752
FU PaLMS Endocrinology Laboratory; Ramsey Research grant
FX We wish to thank Cameron Woods, BSc Biochemistry, Senior Hospital
   Scientist, PaLMS Endocrinology Laboratory and Scientific Fellow PaLMS
   Biochemistry, for his support with serum analyses. Funding for this
   project was received through a JDRF Kickstart grant and a Ramsey
   Research grant.
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NR 63
TC 0
Z9 0
U1 2
U2 3
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD JUL 29
PY 2024
VL 14
IS 1
AR 17363
DI 10.1038/s41598-024-68234-9
PG 14
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA A2B4O
UT WOS:001280635000062
PM 39075112
OA gold
DA 2025-06-11
ER

PT J
AU Akhigbe, RE
   Hamed, MA
AF Akhigbe, R. E.
   Hamed, M. A.
TI Co-administration of HAART and antikoch triggers cardiometabolic
   dysfunction through an oxidative stress-mediated pathway
SO LIPIDS IN HEALTH AND DISEASE
LA English
DT Article
DE Anti-tuberculosis; Anti-retroviral; Oxidative stress; Metabolic
   disorder; Inflammation; Apoptosis
ID ANTIRETROVIRAL THERAPY; CARDIOVASCULAR-DISEASE; PROTEASE INHIBITORS;
   HEPATORENAL DAMAGE; RISK-FACTORS; HIV; GLUTATHIONE; DYSREGULATION;
   PREVALENCE; MECHANISMS
AB BackgroundAntikoch and highly active anti-retroviral therapy are effective drugs in the management of tuberculosis and Human Immunodeficiency Virus, respectively. However, these cocktails have been independently associated with the aetiopathogenesis of metabolic syndrome. This study investigated whether or not the co-administration of antikoch and anti-retroviral, as seen in tuberculosis/Human Immunodeficiency Virus co-infection, will produce a similar effect. Also, it evaluated the role of glutathione and adenine deaminase/xanthine oxidase/uric acid signaling in antikoch/anti-retroviral-induced cardiometabolic dysfunction.MethodsMale rats of Wistar strain were randomized into four groups: the control, which had 0.5 mL of distilled water as a vehicle, anti-Koch-treated rats that were administered a cocktail of anti-Koch, HAART-treated rats that had a combination of anti-retroviral drugs, and anti-Koch+HAART-treated rats that had treatments as anti-Koch-treated and HAART-treated rats. The treatment was once daily and lasted for eight weeks. One way-analysis of variance followed by Tukey's posthoc test was used to test for significance and pairwise comparisons respectively.ResultsAlthough no changes in body weight gain and cardiac weight were noted, it was found that antikoch and/or HAART caused insulin resistance and elevated blood glucose level. In addition, antikoch and/or HAART led to dyslipidaemia, increased atherogenic indices, and elevated cardiac injury markers. These were accompanied by increased plasma and cardiac concentrations of malondialdehyde and nitric oxide, C-reactive protein, and myeloperoxidase activity, as well as suppressed activities of glutathione peroxidase and glutathione-S-transferase, and a fall in reduced glutathione level. The observed alterations were more pronounced in animals that received a combination of antikoch and HAART.ConclusionsThis study provides the first evidence that antikoch and/or HAART induce cardiometabolic dysfunction via glutathione suppression and up-regulation of adenine deaminase/xanthine oxidase/uric acid-dependent oxidative stress and inflammatory response. These events were associated with dyslipidaemia and increased atherogenic indices. This infers that regular monitoring of glucose level, insulin sensitivity, lipid profile, and oxido-inflammatory markers is important in patients on antikoch and/or HAART for prompt diagnosis and management of cardiometabolic disorder if it ensues.
C1 [Akhigbe, R. E.] Ladoke Akintola Univ Technol, Dept Physiol, Ogbomosho, Oyo State, Nigeria.
   [Akhigbe, R. E.; Hamed, M. A.] Oasis Grace Hosp, Reprod Biol & Toxicol Res Labs, Osogbo, Osun State, Nigeria.
   [Akhigbe, R. E.] Kings Univ, Dept Chem Sci, Odeomu, Osun, Nigeria.
   [Hamed, M. A.] Buntai Med & Diagnost Labs, Osogbo, Nigeria.
RP Akhigbe, RE (corresponding author), Ladoke Akintola Univ Technol, Dept Physiol, Ogbomosho, Oyo State, Nigeria.; Akhigbe, RE (corresponding author), Oasis Grace Hosp, Reprod Biol & Toxicol Res Labs, Osogbo, Osun State, Nigeria.; Akhigbe, RE (corresponding author), Kings Univ, Dept Chem Sci, Odeomu, Osun, Nigeria.
EM akhigberoland@gmail.com
RI ; Hamed, Moses/CAH-6613-2022
OI Akhigbe, Roland/0000-0002-3874-5927; Hamed, Moses/0000-0003-3378-6794
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NR 61
TC 15
Z9 15
U1 0
U2 3
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1476-511X
J9 LIPIDS HEALTH DIS
JI Lipids Health Dis.
PD JUL 5
PY 2021
VL 20
IS 1
AR 62
DI 10.1186/s12944-021-01493-x
PG 15
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA TH9WB
UT WOS:000672432400001
PM 34225751
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Iftikhar, N
   Hussain, AI
   Chatha, SAS
   Sultana, N
   Rathore, HA
AF Iftikhar, Neelam
   Hussain, Abdullah Ijaz
   Chatha, Shahzad Ali Shahid
   Sultana, Nazia
   Rathore, Hassaan Anwer
TI Effects of polyphenol-rich traditional herbal teas on obesity and
   oxidative stress in rats fed a high-fat-sugar diet
SO FOOD SCIENCE & NUTRITION
LA English
DT Article
DE BMI; GSH; high-fat diet; kidney index; LDL and HDL; liver index; MDA;
   nutraceutical; phenolic acids and flavonoids; SOD
ID SERUM BILIRUBIN LEVELS; ZINGIBER-OFFICINALE; ANTIOXIDANT ACTIVITY;
   METABOLIC SYNDROME; MORINGA-OLEIFERA; LIPID PROFILE; GINGER;
   CONSTITUENTS; ANTIOBESITY; EXTRACTS
AB Hibiscus rosa-sinensis and Zingiber officinalis teas are traditionally used for the therapies of various diseases, including obesity. The present research work was planned to appraise the potential of polyphenol-rich extracts of selected herbal plants in obesity and related biochemical parameters of high-fat-sugar diet-induced obese rats. Three herbal teas were prepared from Hibiscus rosa-sinensis flowers and Zingiber officinalis rhizomes and their mixture (3:1, respectively). Total phenolic contents (TPC) of Hibiscus rosa-sinensis and Zingiber officinalis extracts were found to be 5.82 and 1.45 mg/g of dry plant material, measured as GAE, while total flavonoid contents (TFC) were 9.17 and 1.95 mg/g of dry plant material, measured as CE, respectively. Two doses (250 and 500 mg/kg BW) of each tea were administered and body weight, BMI, kidney, liver, and atherogenic indices, TC, TG, HDL, LDL, VLDL, BT, AST, ALT, AP, SC, MDA, SOD, GSH, and TAC of rats groups were measured. Data showed that higher doses of Hibiscus rosa-sinensis significantly reduced the rat's BMI (0.50 g/cm(2)) in comparison with the high-fat-sugar diet group (0.79 g/cm(2)). All treatment groups, especially H-500 group, showed a significant decrease in the elevated kidney and liver weights and atherogenic index in comparison with HFSDC groups. Higher doses of Hibiscus rosa-sinensis significantly decreased the levels of AST, ALT, AP, and SC in comparison with the HFSDC group. A significant decrease in the levels of serum TC, TG, LDL, and VLDL was observed in all the treatment groups in comparison with the HFSDC group. Furthermore, all the teas, especially higher doses of Hibiscus rosa-sinensis, prevented the alterations in MDA, SOD, and GSH levels of experimental groups, thus showing the potential against oxidative stress. It can be concluded from these results that Hibiscus rosa-sinensis teas exhibited strong protective effects against obesity and oxidative stress, especially at higher doses.
C1 [Iftikhar, Neelam; Hussain, Abdullah Ijaz; Chatha, Shahzad Ali Shahid; Sultana, Nazia] Govt Coll Univ Faisalabad, Dept Chem, Faisalabad, Pakistan.
   [Hussain, Abdullah Ijaz] Govt Coll Univ Faisalabad, Cent Hitech Lab, Faisalabad, Pakistan.
   [Rathore, Hassaan Anwer] Qatar Univ, QU Hlth, Coll Pharm, Dept Pharmaceut Sci, POB 2713, Doha, Qatar.
   [Rathore, Hassaan Anwer] Qatar Univ, QU Hlth, Biomed & Pharmaceut Res Unit BPRU, Doha, Qatar.
C3 Government College University Faisalabad; Government College University
   Faisalabad; Qatar University; Qatar University
RP Hussain, AI (corresponding author), Govt Coll Univ Faisalabad, Cent Hitech Lab, Faisalabad, Pakistan.; Rathore, HA (corresponding author), Qatar Univ, QU Hlth, Coll Pharm, Dept Pharmaceut Sci, POB 2713, Doha, Qatar.
EM abdullahijaz@gcuf.edu.pk; hrathore@qu.edu.qa
RI Chatha, Shahzad Ali Shahid/F-5891-2013; Rathore, Hassaan/P-1407-2015;
   Hussain, Abdullah/AGI-0192-2022; Chatha, Shahzad Ali
   Shahid/AAA-3961-2021; Rathore, Hassaan Anwer/A-6016-2012
OI Chatha, Shahzad Ali Shahid/0000-0002-5913-2281; Hussain, Abdullah
   Ijaz/0000-0001-7862-8859; Rathore, Hassaan Anwer/0000-0002-1154-9395
FU Qatar University
FX Qatar University
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   World Health Organization (WHO), 2017, WHO FACTSH OB OV 201
NR 47
TC 23
Z9 24
U1 1
U2 29
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2048-7177
J9 FOOD SCI NUTR
JI Food Sci. Nutr.
PD MAR
PY 2022
VL 10
IS 3
BP 698
EP 711
DI 10.1002/fsn3.2695
EA JAN 2022
PG 14
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA ZP6CK
UT WOS:000741019100001
PM 35311163
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Werkkala, C
   Välimäki, M
   Anttila, M
   Pekurinen, V
   Bressington, D
AF Werkkala, Camilla
   Valimaki, Maritta
   Anttila, Minna
   Pekurinen, Virve
   Bressington, Daniel
TI Validation of the Finnish Health Improvement Profile (HIP) with patients
   with severe mental illness
SO BMC PSYCHIATRY
LA English
DT Article
DE Severe mental illness; Physical health; Assessment; Validation
ID QUALITY-OF-LIFE; PHYSICAL HEALTH; PSYCHOTIC DISORDERS; METABOLIC
   SYNDROME; CONTENT VALIDITY; SEXUAL HEALTH; SCHIZOPHRENIA; PEOPLE;
   MORTALITY; OBESITY
AB Background Physical health among people with severe mental illness (SMI) is a global concern. However, many people with SMI do not receive regular comprehensive health checks. There is currently no validated physical health check instrument systematically used in Finnish mental health services. Therefore, this study aims to validate and establish the potential clinical utility of the translated Health Improvement Profile (HIP) tool for Finnish patients with SMI and compare differences in physical health risk items across genders. Methods The content validity of the two-way translated Finnish HIP (HIP-F) was evaluated by five nurses and four patients with SMI using cognitive debriefing (to assess the clarity and relevance of each item and the recommended actions of the HIP tool). The potential clinical utility was assessed using a pilot test involving 47 patients. The prevalence of red-flagged (risk) items in the whole sample, across female and male participants, and the frequencies of any type of missing item response were calculated and analysed using descriptive statistics. A chi-square test was used to determine differences in frequencies of red-flagged items across genders. Results Based on the cognitive debriefing, the HIP-F was found to have moderate content validity regarding the clarity and relevance of the items and recommended actions (the average scale level content validity index, S-CVI/Ave, 0.74). In the pilot test, some missing item responses were identified, but in the sample, nurses identified 399 areas of health and health behaviour risks (mean 8.6 per patient) using the HIP-F. The most frequently red-flagged items were body mass index (BMI) and waist circumference (83.0%), smoking status (48.9%) and lipid levels (46.8%). Female patients had a higher frequency of red-flagged items than males in BMI (92.6% vs. 70.0%, p = 0.04) and waist circumference (96.3% vs. 65.0%, p = 0.01). Conclusions The results demonstrate that the Finnish HIP has moderate content validity and preliminary clinical utility for evaluating the physical health and health behaviours of people with SMI. The HIP-F findings help to sign-post evidence-based interventions for identified areas of concern. Additional nurse training may be necessary to realise the potential clinical utility of the tool in Finland.
C1 [Werkkala, Camilla; Valimaki, Maritta; Anttila, Minna; Pekurinen, Virve] Univ Turku, Dept Nursing Sci, Joukahaisenkatu 3-5, Turku 20014, Finland.
   [Valimaki, Maritta; Bressington, Daniel] Hong Kong Polytech Univ, Hung Hom, Hong Kong, Peoples R China.
C3 University of Turku; Hong Kong Polytechnic University
RP Werkkala, C (corresponding author), Univ Turku, Dept Nursing Sci, Joukahaisenkatu 3-5, Turku 20014, Finland.
EM camaka@utu.fi
RI Välimäki, Maritta/JTV-2461-2023; Valimaki, Maritta/E-7092-2017;
   Bressington, Daniel/G-2789-2017
OI Langstedt, Camilla/0000-0002-5812-5768; Valimaki,
   Maritta/0000-0001-7234-2454; Bressington, Daniel/0000-0003-0951-2208
FU University of Turku, Department of Nursing Science [26003424]
FX This research is funded by the University of Turku, Department of
   Nursing Science (code 26003424, grant holder MV). The funder had no role
   in study design, data collection, analysis, interpretation of data,
   decision to publish, or preparation of the manuscript.
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NR 73
TC 7
Z9 7
U1 1
U2 2
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-244X
J9 BMC PSYCHIATRY
JI BMC Psychiatry
PD MAR 11
PY 2020
VL 20
IS 1
AR 112
DI 10.1186/s12888-020-02511-5
PG 15
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA KU8PY
UT WOS:000519975400002
PM 32160873
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Rahman, MM
   Alam, MN
   Ulla, A
   Sumi, FA
   Subhan, N
   Khan, T
   Sikder, B
   Hossain, H
   Reza, HM
   Alam, MA
AF Rahman, Md Mizanur
   Alam, Mohammad Nazmul
   Ulla, Anayt
   Sumi, Farzana Akther
   Subhan, Nusrat
   Khan, Trisha
   Sikder, Bishwajit
   Hossain, Hemayet
   Reza, Hasan Mahmud
   Alam, Md Ashraful
TI Cardamom powder supplementation prevents obesity, improves glucose
   intolerance, inflammation and oxidative stress in liver of high
   carbohydrate high fat diet induced obese rats
SO LIPIDS IN HEALTH AND DISEASE
LA English
DT Article
DE Cardamom; Glucose intolerance; Dyslipidemia; Obesity; Inflammation;
   Fibrosis
ID INSULIN-RESISTANCE; METABOLIC SYNDROME; ELETTARIA-CARDAMOMUM; DISEASE;
   DYSLIPIDEMIA; DYSFUNCTION; MECHANISMS; MARKER; IMPACT; OXIDE
AB Background: Cardamom is a well-known spice in Indian subcontinent, used in culinary and traditional medicine practices since ancient times. The current investigation was untaken to evaluate the potential benefit of cardamom powder supplementation in high carbohydrate high fat (HCHF) diet induced obese rats.
   Method: Male Wistar rats (28 rats) were divided into four different groups such as Control, Control + cardamom, HCHF, HCHF + cardamom. High carbohydrate and high fat (HCHF) diet was prepared in our laboratory. Oral glucose tolerance test, organs wet weight measurements and oxidative stress parameters analysis as well as liver marker enzymes such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) activities were assayed on the tissues collected from the rats. Plasma lipids profiles were also measured in all groups of animals. Moreover, histological staining was also performed to evaluate inflammatory cells infiltration and fibrosis in liver.
   Results: The current investigation showed that, HCHF diet feeding in rats developed glucose intolerance and increased peritoneal fat deposition compared to control rats. Cardamom powder supplementation improved the glucose intolerance significantly (p > 0.05) and prevented the abdominal fat deposition in HCHF diet fed rats. HCHF diet feeding in rats also developed dyslipidemia, increased fat deposition and inflammation in liver compared to control rats. Cardamom powder supplementation significantly prevented the rise of lipid parameters (p > 0.05) in HCHF diet fed rats. Histological assessments confirmed that HCHF diet increased the fat deposition and inflammatory cells infiltration in liver which was normalized by cardamom powder supplementation in HCHF diet fed rats. Furthermore, HCHF diet increased lipid peroxidation, decreased antioxidant enzymes activities and increased advanced protein oxidation product level significantly (p > 0.05) both in plasma and liver tissue which were modulated by cardamom powder supplementation in HCHF diet fed rats. HCHF diet feeding in rats also increased the ALT, AST and ALP enzyme activities in plasma which were also normalized by cardamom powder supplementation in HCHF diet fed rats. Moreover, cardamom powder supplementation ameliorated the fibrosis in liver of HCHF diet fed rats.
   Conclusion: This study suggests that, cardamom powder supplementation can prevent dyslipidemia, oxidative stress and hepatic damage in HCHF diet fed rats.
C1 [Rahman, Md Mizanur; Alam, Mohammad Nazmul; Ulla, Anayt; Sumi, Farzana Akther; Subhan, Nusrat; Khan, Trisha; Sikder, Bishwajit; Reza, Hasan Mahmud; Alam, Md Ashraful] North South Univ, Dept Pharmaceut Sci, Dhaka 1229, Bangladesh.
   [Hossain, Hemayet] BCSIR, BCSIR Labs, Dhaka, Bangladesh.
C3 North South University (NSU); Bangladesh Council of Scientific &
   Industrial Research (BCSIR); BCSIR Laboratories Dhaka
RP Alam, MA (corresponding author), North South Univ, Dept Pharmaceut Sci, Dhaka 1229, Bangladesh.
EM sonaliagun@yahoo.com
RI hossain, hemayet/O-5996-2018; Alam, Ashraful/G-1964-2014; Ulla,
   Anayt/AGJ-3338-2022; Rahman, Md Mizanur/AAC-7666-2019; Reza, Hasan
   Mahmud/AFL-0151-2022
OI Rahman, Md Mizanur/0000-0002-7178-7977; Ulla, Anayt/0000-0002-1733-5734;
   Hossain, Hemayet/0000-0001-8759-9279; Alam, Md
   Ashraful/0000-0001-7596-5868; Reza, Hasan Mahmud/0000-0003-3287-942X
FU Ministry of Science and Technology, Bangladesh
FX Partial support was received as Research Grant (R and D), 2015-1016 from
   Ministry of Science and Technology, Bangladesh.
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NR 50
TC 60
Z9 61
U1 1
U2 16
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1476-511X
J9 LIPIDS HEALTH DIS
JI Lipids Health Dis.
PD AUG 14
PY 2017
VL 16
AR 151
DI 10.1186/s12944-017-0539-x
PG 12
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA FD7OS
UT WOS:000407716000002
PM 28806968
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Sodhi, K
   Puri, N
   Kim, DH
   Hinds, TD
   Stechschulte, LA
   Favero, G
   Rodella, L
   Shapiro, JI
   Jude, D
   Abraham, NG
AF Sodhi, K.
   Puri, N.
   Kim, D. H.
   Hinds, T. D.
   Stechschulte, L. A.
   Favero, G.
   Rodella, L.
   Shapiro, J. I.
   Jude, D.
   Abraham, N. G.
TI RETRACTED: PPARδ binding to heme oxygenase 1 promoter prevents
   angiotensin II-induced adipocyte dysfunction in Goldblatt hypertensive
   rats (Retracted Article)
SO INTERNATIONAL JOURNAL OF OBESITY
LA English
DT Article; Retracted Publication
DE PPAR delta; HO-1; adipogenesis; angiotensin II; adiponectin
ID ACTIVATED RECEPTOR-DELTA; IMPROVES INSULIN SENSITIVITY; INCREASES
   ADIPONECTIN LEVELS; MESENCHYMAL STEM-CELLS; HIGH-FAT DIET; VASCULAR
   DYSFUNCTION; METABOLIC SYNDROME; OXIDATIVE STRESS; OBESE MICE; IN-VITRO
AB OBJECTIVE: Renin-angiotensin system (RAS) regulates adipogenic response with adipocyte hypertrophy by increasing oxidative stress. Recent studies have shown the role of peroxisome proliferator-activated receptor-delta (PPAR delta) agonist in attenuation of angiotensin II-induced oxidative stress. The aim of this study was to explore a potential mechanistic link between PPAR delta and the cytoprotective enzyme heme oxygenase-1 (HO-1) and to elucidate the contribution of HO-1 to the adipocyte regulatory effects of PPAR delta agonism in an animal model of enhanced RAS, the Goldblatt 2 kidney 1 clip (2K1C) model.
   METHOD: We first established a direct stimulatory effect of the PPAR delta agonist (GW 501516) on the HO-1 gene by demonstrating increased luciferase activity in COS-7 cells transfected with a luciferase-HO-1 promoter construct. Sprague-Dawley rats were divided into four groups: sham-operated animals, 2K1C rats and 2K1C rats treated with GW 501516, in the absence or presence of the HO activity inhibitor, stannous mesoporphyrin (SnMP).
   RESULTS: 2K1C animals had increased visceral adiposity, adipocyte hypertrophy, increased inflammatory cytokines, increased circulatory and adipose tisssue levels of renin and Ang II along with increased adipose tissue gp91 phox expression (P<0.05) when compared with sham-operated animals. Treatment with GW 501516 increased adipose tissue HO-1 and adiponectin levels (P<0.01) along with enhancement of Wnt10b and beta-catenin expression. HO-1 induction was accompanied by the decreased expression of Wnt5b, mesoderm specific transcript (mest) and C/EBP alpha levels and an increased number of small adipocytes (P<0.05). These effects of GW501516 were reversed in 2K1C animals exposed to SnMP (P<0.05).
   CONCLUSION: Taken together, our study demonstrates, for the first time, that increased levels of Ang II contribute towards adipose tissue dysregulation, which is abated by PPAR delta-mediated upregulation of the heme-HO system. These findings highlight the pivotal role and symbiotic relationship of HO-1, adiponectin and PPAR delta in the regulation of metabolic homeostasis in adipose tissues.
C1 [Sodhi, K.; Kim, D. H.; Shapiro, J. I.; Jude, D.; Abraham, N. G.] Marshall Univ, Joan C Edwards Sch Med, Dept Med, Huntington, WV 25755 USA.
   [Puri, N.; Hinds, T. D.; Stechschulte, L. A.] Univ Toledo, Coll Med, Dept Physiol & Pharmacol, Toledo, OH 43606 USA.
   [Favero, G.; Rodella, L.] Univ Brescia, Div Anat, Dept Biomed Sci, Brescia, Italy.
C3 Marshall University; University System of Ohio; University of Toledo;
   University of Brescia
RP Abraham, NG (corresponding author), Marshall Univ, Joan C Edwards Sch Med, Dept Med, Huntington, WV 25755 USA.
EM abrahamn@marshall.edu
RI Rodella, Luigi/F-1079-2010; Kim, Dong/W-5846-2019; Hinds,
   Terry/B-8495-2015
OI Rodella, Luigi Fabrizio/0000-0002-9497-4708; Hinds,
   Terry/0000-0002-7599-1529; Favero, Gaia/0000-0001-6895-7106
FU National Institutes of Health [DK56601, HL-34300]; Brickstreet
   Foundation Inc.
FX We had full access to the data and take responsibility for its
   integrity. We have read and agreed with the manuscript as written. This
   work was supported by National Institutes of Health grants DK56601,
   HL-34300 and Brickstreet Foundation Inc. We thank Jennifer Brown for her
   outstanding editorial assistance in the preparation of the manuscript.
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NR 32
TC 24
Z9 26
U1 0
U2 8
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0307-0565
EI 1476-5497
J9 INT J OBESITY
JI Int. J. Obes.
PD MAR
PY 2014
VL 38
IS 3
BP 456
EP 465
DI 10.1038/ijo.2013.116
PG 10
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA AC9DY
UT WOS:000332835700019
PM 23779049
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Tabak, RG
   Schwarz, CD
   Kemner, A
   Schechtman, KB
   Steger-May, K
   Byrth, V
   Haire-Joshu, D
AF Tabak, Rachel G.
   Schwarz, Cynthia D.
   Kemner, Allison
   Schechtman, Kenneth B.
   Steger-May, Karen
   Byrth, Veronda
   Haire-Joshu, Debra
TI Disseminating and implementing a lifestyle-based healthy weight program
   for mothers in a national organization: a study protocol for a cluster
   randomized trial
SO IMPLEMENTATION SCIENCE
LA English
DT Article
ID DIABETES-PREVENTION-PROGRAM; REAL-WORLD SETTINGS; TRANSLATIONAL
   RESEARCH; MENTAL-HEALTH; IMPROVE TRANSLATION; OBESITY PREVENTION;
   METABOLIC SYNDROME; AFRICAN-AMERICAN; AIM FRAMEWORK; GAIN
AB BackgroundExcessive weight gain among young adult women age 18-45years is an alarming and overlooked trend that must be addressed to reverse the epidemics of obesity and chronic disease. During this vulnerable period, women tend to gain disproportionally large amounts of weight compared to men and to other life periods. Healthy Eating and Active Living Taught at Home (HEALTH) is a lifestyle modification intervention developed in partnership with Parents as Teachers (PAT), a national home visiting, community-based organization with significant reach in this population. HEALTH prevented weight gain, promoted sustained weight loss, and reduced waist circumference. PAT provides parent-child education and services free of charge to nearly 170,000 families through up to 25 free home visits per year until the child enters kindergarten.MethodsThis study extends effectiveness findings with a pragmatic cluster randomized controlled trial to evaluate dissemination and implementation (D&I) of HEALTH across three levels (mother, parent educator, PAT site). The trial will evaluate the effect of HEALTH and the HEALTH training curriculum (implementation strategy) on weight among mothers with overweight and obesity across the USA (N=252 HEALTH; N=252 usual care). Parent educators from 28 existing PAT sites (14 HEALTH, 14 usual care) will receive the HEALTH training curriculum through PAT National Center, using PAT's existing training infrastructure, as a continuing education opportunity. An extensive evaluation, guided by RE-AIM (Reach, Effectiveness, Adoption, Implementation, Maintenance), will determine implementation outcomes (acceptability, adoption, appropriateness, feasibility, fidelity, and adaptation) at the parent educator level. The Conceptual Framework for Implementation Research will characterize determinants that influence HEALTH D&I at three levels: mother, parent educator, and PAT site to enhance external validity (reach and maintenance).DiscussionEmbedding intervention content within existing delivery channels can help expand the reach of evidence-based interventions. Interventions, which have been adapted, can still be effective even if the effect is reduced and can still achieve population impact by reaching a broader set of the population. The current study will build on this to test not only the effectiveness of HEALTH in real-world PAT implementation nationwide, but also elements critical to D&I, implementation outcomes, and the context for implementation.Trial registrationhttps://ClinicalTrials.gov, NCT03758638. Registered 29 November 2018
C1 [Tabak, Rachel G.; Schwarz, Cynthia D.; Byrth, Veronda; Haire-Joshu, Debra] Washington Univ, Brown Sch, 1 Brookings Dr, St Louis, MO 63130 USA.
   [Kemner, Allison] Parents Teachers, Res & Qual, 2228 Ball Dr, St Louis, MO 63146 USA.
   [Schechtman, Kenneth B.; Steger-May, Karen] Washington Univ, Sch Med, Div Biostat, 660 S Euclid Ave,CB 8067, St Louis, MO 63110 USA.
   [Haire-Joshu, Debra] Washington Univ, Sch Med, 1 Brookings Dr, St Louis, MO 63130 USA.
C3 Washington University (WUSTL); Washington University (WUSTL); Washington
   University (WUSTL)
RP Tabak, RG (corresponding author), Washington Univ, Brown Sch, 1 Brookings Dr, St Louis, MO 63130 USA.
EM rtabak@wustl.edu
RI Tabak, Rachel/ABH-9078-2022
OI Tabak, Rachel/0000-0003-2967-3906
FU NIDDK [R18DK089461, P30DK092950]; NHLBI of the National Institutes of
   Health (NIH) [1R01HL143360]; Washington University Institute of Clinical
   and Translational Sciences from the National Center for Advancing
   Translational Sciences (NCATS) of the NIH [UL1TR002345]
FX This publication was made possible by Grant Numbers R18DK089461 and
   P30DK092950 from the NIDDK and 1R01HL143360 from NHLBI of the National
   Institutes of Health (NIH). In addition, research reported in this
   publication was supported by the Washington University Institute of
   Clinical and Translational Sciences grant UL1TR002345 from the National
   Center for Advancing Translational Sciences (NCATS) of the NIH. The
   content is solely the responsibility of the authors and does not
   necessarily represent the official view of the NIH.
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NR 104
TC 9
Z9 9
U1 0
U2 3
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1748-5908
J9 IMPLEMENT SCI
JI Implement. Sci.
PD JUN 25
PY 2019
VL 14
AR 68
DI 10.1186/s13012-019-0916-0
PG 14
WC Health Care Sciences & Services; Health Policy & Services
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services
GA IF2BF
UT WOS:000472881400001
PM 31238955
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Wu, H
   Liu, YX
   Wang, J
   Chen, SY
   Xie, LW
   Wu, XL
AF Wu, Hui
   Liu, Yaxi
   Wang, Jie
   Chen, Shengyun
   Xie, Liwei
   Wu, Xiaoli
TI Schizophrenia and obesity: May the gut microbiota serve as a link for
   the pathogenesis?
SO IMETA
LA English
DT Review
DE gut microbiota; obesity; prebiotics; probiotics; schizophrenia
ID 1ST-EPISODE DRUG-NAIVE; NECROSIS-FACTOR-ALPHA; C-REACTIVE PROTEIN; CHAIN
   FATTY-ACIDS; METABOLIC SYNDROME; INTESTINAL MICROBIOTA; NUTRIENT
   ABSORPTION; INSULIN SENSITIVITY; HOST GENETICS; WEIGHT-GAIN
AB Schizophrenia (SZ) places a tremendous burden on public health as one of the leading causes of disability and death. SZ patients are more prone to developing obesity than the general population from the clinical practice. The development of obesity frequently causes poor psychiatric outcomes in SZ patients. In turn, maternal obesity during pregnancy has been associated with an increased risk of SZ in offspring, suggesting that these two disorders may have shared neuropathological mechanisms. The gut microbiota is well known to serve as a major regulator of bidirectional interactions between the central nervous system and the gastrointestinal tract. It also plays a critical role in maintaining physical and mental health in humans. Recent studies have shown that the dysbiosis of gut microbiota is intimately associated with the onset of SZ and obesity through shared pathophysiological mechanisms, particularly the stimulation of immune inflammation. Therefore, gut microbiota may serve as a common biological basis for the etiology in both SZ and obesity, and the perturbed gut-brain axis may therefore account for the high prevalence of obesity in patients with SZ. On the basis of these findings, this review provides updated perspectives and intervention approaches on the etiology, prevention, and management of obesity in SZ patients by summarizing the recent findings on the role of gut microbiota in the pathogenesis of SZ and obesity, highlighting the role of gut-derived inflammation.
   This review provides updated perspectives on the etiology, prevention, and management of obesity in SZ patients by summarizing the recent findings on the role of gut microbiota in the pathogenesis of SZ and obesity, highlighting the role of gut-derived inflammation.image
   Obesity represents a major challenge to the clinical management of schizophrenia (SZ) and contributes to worse psychiatric outcomes in SZ.Perturbations in gut-brain axis, particularly gut-derived inflammation, are closely related to the pathogenesis of both SZ and obesity, suggesting that gut microbiota may be a potential hub linking these two disorders.Gut microbiota is a modifiable component that may be used as a novel therapeutic option for treating obesity or improving psychiatric outcomes in SZ patients.Future research on obesity in SZ includes understanding the therapeutic potential of the gut microbiota, its temporospatial dynamics, its mechanistic interaction with the host, and the crosstalk between the gut and the brain.
C1 [Wu, Hui; Liu, Yaxi; Chen, Shengyun; Wu, Xiaoli] Sun Yat Sen Univ, Affiliated Hosp 3, Psychiat Dept, Guangzhou, Peoples R China.
   [Wang, Jie; Xie, Liwei] Guangdong Acad Sci, Inst Microbiol, State Key Lab Appl Microbiol Southern China, Guangdong Prov Key Lab Microbial Culture Collect, Guangzhou, Peoples R China.
   [Wang, Jie] Imperial Coll London, Dept Life Sci, London, England.
C3 Sun Yat Sen University; Guangdong Academy of Sciences; Imperial College
   London
RP Xie, LW (corresponding author), Guangdong Acad Sci, Inst Microbiol, State Key Lab Appl Microbiol Southern China, Guangdong Prov Key Lab Microbial Culture Collect, Guangzhou 510070, Peoples R China.; Wu, XL (corresponding author), Sun Yat Sen Univ, Affiliated Hosp 3, Psychiat Dept, Guangzhou 510630, Peoples R China.
EM xielw@gdim.cn; wuxiaoli@mail.sysu.edu.cn
RI 吴, 小立/HMP-3438-2023
OI wu, xiaoli/0000-0001-7530-5317; wu, hui/0000-0002-1757-9990
FU Natural Science Foundation of Guangdong Province; Guangdong Basic and
   Applied Basic Research Foundation [2020B1515020046];  [2020A1515011288];
    [81900797];  [82072436]
FX This work was supported by the Natural Science Foundation of Guangdong
   Province (Grant No. 2020A1515011288) to Xiaoli Wu, National Natural
   Science Foundation of China (Grant Nos. 81900797 and 82072436), and
   Guangdong Basic and Applied Basic Research Foundation (Grant No.
   2020B1515020046) to Liwei Xie.
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NR 145
TC 11
Z9 12
U1 2
U2 9
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2770-5986
EI 2770-596X
J9 IMETA
JI iMeta
PD MAY
PY 2023
VL 2
IS 2
AR e99
DI 10.1002/imt2.99
PG 23
WC Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Microbiology
GA EC4B6
UT WOS:001136690300006
PM 38868440
OA gold
DA 2025-06-11
ER

PT J
AU Per, BL
   Loeser, S
   Edwards, S
   Lee, WS
   Wilton, LR
   Clark, SR
AF Per, Bee Leng
   Loeser, Susan
   Edwards, Suzanne
   Lee, Wen Siew
   Wilton, Lisa R.
   Clark, Scott Richard
TI The Impact of Metformin on Weight and Waist Circumference in Patients
   Treated With Clozapine: A One-Year Retrospective Cohort Study
SO ACTA PSYCHIATRICA SCANDINAVICA
LA English
DT Article
DE antipsychotic; clozapine; metformin; obesity; weight loss
ID ATYPICAL ANTIPSYCHOTICS; METABOLIC SYNDROME; RELATIVE RISK; SHORT-TERM;
   SCHIZOPHRENIA; GAIN; ASSOCIATION; MICROBIOTA; APPETITE; OBESITY
AB Background: Metformin shows potential in combating clozapine-induced weight gain (CIWG). However, current evidence for its use remains limited. Through an audit we determined the prevalence of metformin use among clozapine-treated patients and its impact on weight and waist circumference (WC). Methods: This retrospective cohort study examined electronic medical records of community-based clozapine patients under the care of metropolitan community mental health teams within the Central Adelaide Local Health Network (CALHN) from January 2014 to June 2023. We included patients treated with clozapine both with and without metformin, above 18 years of age, with complete physical monitoring data at baseline, 6, and 12 months. Results: There were 357 patients, who met study criteria. Metformin was prescribed to 23% of patients, of whom 78% had diabetes. At baseline, WC was > 101 cm in 71% of males and > 87 cm in 86% of females, placing them at increased risk of weight-related comorbidities, including cardiovascular disease, cancer, and death. After 1 year, males and females in the highest risk group for WC-related comorbidities increased to 76.3% and 95.4%, respectively. Co-prescription of metformin with clozapine was associated with unadjusted mean weight loss (-1.67 kg) and decrease in WC (-1.00 cm). Patients not using metformin gained weight (0.68 kg) and WC (2.49 cm). Using a linear mixed-effects models adjusting for repeated measurements, age, sex, and type 2 diabetes, over 12 months, patients treated with metformin were 3.08 kg lighter than those not taking metformin (95% confidence interval [CI]: 0.54-5.62, p = 0.018). Similar models suggested patients treated with metformin showed an average 2.83 cm decrease in WC compared with those not taking metformin (CI: 0.26-5.40, p = 0.03). There was no significant interaction between difference from baseline in weight or WC and metformin dose (p > 0.05). Discussion/Conclusion: The prevalence of metformin use for CIWG appears low in this cohort, where over 84% of patients were overweight or obese. Metformin use was associated with a significantly lower incidence of weight and WC gain over 12 months. Pharmacists are crucial for educating clinicians and patients about the benefits of metformin for reducing CIWG.
C1 [Per, Bee Leng; Loeser, Susan; Lee, Wen Siew; Wilton, Lisa R.; Clark, Scott Richard] Cent Adelaide Local Hlth Network, Adelaide, SA, Australia.
   [Per, Bee Leng; Loeser, Susan; Lee, Wen Siew] Cent Adelaide Local Hlth Network, SA Pharm, Adelaide, SA, Australia.
   [Edwards, Suzanne; Clark, Scott Richard] Basil Hetzel Inst, Woodville South, SA, Australia.
   [Wilton, Lisa R.] Off Chief Psychiatrist, Adelaide, SA, Australia.
   [Clark, Scott Richard] Univ Adelaide, Discipline Psychiat, Adelaide, SA, Australia.
C3 Basil Hetzel Institute; University of Adelaide
RP Clark, SR (corresponding author), Cent Adelaide Local Hlth Network, Adelaide, SA, Australia.; Clark, SR (corresponding author), Basil Hetzel Inst, Woodville South, SA, Australia.; Clark, SR (corresponding author), Univ Adelaide, Discipline Psychiat, Adelaide, SA, Australia.
EM scott.clark@adelaide.edu.au
FU The University of Adelaide; University of Adelaide, as part of the Wiley
   - The University of Adelaide agreement via the Council of Australian
   University Librarians
FX Special thanks to pharmacy student Kit Hung Chung from the University of
   South Australia for his assistance in locating relevant literature, data
   entering, and data cleaning for this study. Open access publishing
   facilitated by The University of Adelaide, as part of the Wiley - The
   University of Adelaide agreement via the Council of Australian
   University Librarians.
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NR 56
TC 0
Z9 0
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0001-690X
EI 1600-0447
J9 ACTA PSYCHIAT SCAND
JI Acta Psychiatr. Scand.
PD JUN
PY 2025
VL 151
IS 6
BP 719
EP 730
DI 10.1111/acps.13796
EA MAR 2025
PG 12
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 2EE6I
UT WOS:001441249400001
PM 40066758
OA hybrid
DA 2025-06-11
ER

PT J
AU Zitzmann, M
AF Zitzmann, Michael
TI Testosterone deficiency and chronic kidney disease
SO JOURNAL OF CLINICAL AND TRANSLATIONAL ENDOCRINOLOGY
LA English
DT Article
DE Testosterone; Testosterone Therapy; Male hypogonadism; Classical Male
   hypogonadism; Functional Male hypogonadism; Chronic Kidney Disease
ID METABOLIC SYNDROME; INSULIN-RESISTANCE; MEN; HYPOGONADISM; REPLACEMENT;
   DYSFUNCTION; ANEMIA; RISK; ANDROGENS; MORTALITY
AB Testosterone's biological functions are extensive, influencing reproductive and systemic health. It plays a vital role in sexual functions, muscle protein synthesis, bone metabolism, fat distribution, and cardiovascular health. The hormone also affects mood, cognitive function, and erythropoiesis, underscoring its importance in both physical and mental health. Testosterone deficiency, or male hypogonadism, is increasingly recognized as a significant health issue affecting various bodily systems, also in the context of chronic kidney disease (CKD). Recent research indicates a complex interplay between testosterone levels and renal health, suggesting that male hypogonadism may both impact and be impacted by CKD. The latter is characterized by a gradual loss of kidney function, affects millions globally and is often associated with diabetes mellitus, arterial hypertension, and autoimmune diseases. Men with CKD frequently experience lower testosterone levels, which can exacerbate muscle wasting, reduce quality of life, and increase cardiovascular risk. Overall, low testosterone levels in CKD patients are associated with increased morbidity and mortality. Several mechanisms explain the relationship between CKD and testosterone deficiency. The uremic environment in CKD disrupts the hypothalamic-pituitary-gonadal axis, impairing hormone production. Nutritional deficiencies and chronic inflammation common in CKD patients further suppress gonadal function. The consequences of low testosterone in CKD are profound, with studies suggesting that testosterone replacement therapy (TRT) might improve clinical outcomes, though the long-term effects and causal relationships remain under investigation. The potential benefits of TRT in CKD patients might be significant. TRT can enhance muscle mass and strength, address anemia by stimulating erythropoiesis, improve bone density, and possibly offer cardiovascular benefits by improving body composition and insulin sensitivity. General symptoms of male hypogonadism, such as deteriorated psychological, sexual and physical wellbeing, can be improved by TRT. However, these benefits must be weighed against potential risks. TRT may exacerbate fluid retention, arterial hypertension, or exacerbate existing heart failure, particularly in CKD patients with pre-existing cardiovascular comorbidities. Additionally, concerns about the progression of renal disease via several testosterone affected pathways involving renal tubular integrity exist, highlighting the need for careful patient selection and monitoring. Understanding this relationship is crucial for developing comprehensive treatment strategies that address both renal and endocrine dysfunctions, highlighting the need for integrated patient care, which means good collaboration between subspecialists like nephrologists, endocrinologists, urologists and primary care providers, aiming to improve outcomes and quality of life while mitigating adverse effects.
C1 [Zitzmann, Michael] Ctr Reprod Med & Androl Univ, Domagkstr 11, D-48149 Munster, Germany.
RP Zitzmann, M (corresponding author), Ctr Reprod Med & Androl Univ, Domagkstr 11, D-48149 Munster, Germany.
EM Michael.Zitzmann@ukmuenster.de
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NR 79
TC 3
Z9 3
U1 1
U2 4
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2214-6237
J9 J CLIN TRANSL ENDOCR
JI J. Clin. Transl. ENdocrinol.
PD SEP
PY 2024
VL 37
AR 100365
DI 10.1016/j.jcte.2024.100365
EA AUG 2024
PG 11
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA D7P3K
UT WOS:001298061900001
PM 39253627
OA gold
DA 2025-06-11
ER

PT J
AU Yarborough, BJH
   Leo, MC
   Stumbo, S
   Perrin, NA
   Green, CA
AF Yarborough, Bobbi Jo H.
   Leo, Michael C.
   Stumbo, Scott
   Perrin, Nancy A.
   Green, Carla A.
TI STRIDE: a randomized trial of a lifestyle intervention to promote weight
   loss among individuals taking antipsychotic medications
SO BMC PSYCHIATRY
LA English
DT Article
DE Antipsychotic medications; Serious mental illness; Obesity; Lifestyle
   change; Weight loss; Physical activity; Diabetes risk; Blood pressure;
   Lipids
ID HEALTH SURVEY SF-36; HEART-DISEASE RISK; QUALITY-OF-LIFE;
   BLOOD-PRESSURE; METABOLIC SYNDROME; DIABETES-MELLITUS; MENTAL ILLNESSES;
   SCHIZOPHRENIA; OUTCOMES; PREMIER
AB Background: Individuals diagnosed with serious mental illnesses are at increased risk of obesity-and cardiovascular-related morbidity and early mortality. Lifestyle interventions aimed at weight loss, even those adapted to suit the needs of this particular subgroup, have rarely produced clinically meaningful reductions in weight.
   Methods/design: The STRIDE study is a multi-site, parallel, two-arm randomized controlled translational trial. Participants were recruited from community mental health clinics and an integrated not-for-profit health system. Participants were randomized either to usual care or to a 12-month intervention that consisted of: 1) weekly group participation for six months covering topics on nutrition, physical activity and lifestyle changes; 2) monthly group participation for an additional six month maintenance period; and 3) individual monthly contacts from intervention group facilitators during the second six month phase. All participants are assessed at baseline, 6, 12, and 24 months post-enrollment. Process and implementation evaluations are included and the study design includes a cost-utility analysis. Participants include 200 individuals with serious mental illness with an average age of 47.1 years, a mean body-mass index of 38.3 kg/m2 and taking an average of 3.2 psychiatric medications at baseline. Baseline physiological measures included mean blood pressure (SBP/DBP) measurements of 119.2 (SD = 14.7)/79.4 (SD = 10.1); 35% reported a hypertension diagnosis and 11% took antihypertensive medications. Average lipid levels (mg/dL) were: a) triglycerides 188.0 (SD = 138.6), ranged from 43 to 1145; b) LDL 101.4 (SD = 32.9) and ranged from 17 to 185; c) HDL 45.8 (SD = 12.7) and ranged from 22 to 89; and d) total cholesterol 181.6 (SD = 39.7) and ranged from 50 to 324. Average fasting glucose levels were 108.9 (SD = 32.5) and ranged from 24 to 289. Average fasting insulin levels were 13.0 (SD= 11.9) and ranged from 2 to 99.
   Discussion: The STRIDE study is based on a modified version of the PREMIER comprehensive lifestyle intervention, DASH diet arm. STRIDE has successfully enrolled 200 individuals with serious mental illness in community-based settings. Baseline characteristics present a population at high risk for obesity-related negative health outcomes and demonstrate the need for evidence-based interventions to reduce these risks.
C1 [Yarborough, Bobbi Jo H.; Leo, Michael C.; Stumbo, Scott; Perrin, Nancy A.; Green, Carla A.] Kaiser Permanente Ctr Hlth Res, Portland, OR 97227 USA.
C3 Kaiser Permanente
RP Yarborough, BJH (corresponding author), Kaiser Permanente Ctr Hlth Res, 3800 N Interstate Ave, Portland, OR 97227 USA.
EM bobbijo.h.yarborough@kpchr.org
RI ; Green, Carla/D-2534-2017
OI Stumbo, Scott/0000-0002-4351-4242; Green, Carla/0000-0002-0000-4381
FU National Institute of Diabetes and Digestive and Kidney Diseases
   [R18DK076775]; Reducing Weight and Diabetes Risk in an Underserved
   Population
FX Funding for this study is provided by the National Institute of Diabetes
   and Digestive and Kidney Diseases, Grant R18DK076775, Reducing Weight
   and Diabetes Risk in an Underserved Population.
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NR 64
TC 27
Z9 27
U1 1
U2 31
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-244X
J9 BMC PSYCHIATRY
JI BMC Psychiatry
PD SEP 28
PY 2013
VL 13
AR 238
DI 10.1186/1471-244X-13-238
PG 11
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 243BY
UT WOS:000326292700001
PM 24074269
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Zuchi, C
   Tritto, I
   Ambrosio, G
AF Zuchi, Cinzia
   Tritto, Isabella
   Ambrosio, Giuseppe
TI Angina pectoris in women: Focus on microvascular disease
SO INTERNATIONAL JOURNAL OF CARDIOLOGY
LA English
DT Review
DE Angina pectoris; Women; Ischemic heart disease; Antianginal drugs;
   Microcirculation
ID CORONARY-ARTERY-DISEASE; ISCHEMIA SYNDROME EVALUATION; CARDIAC
   SYNDROME-X; SYNDROME EVALUATION WISE; CHRONIC STABLE ANGINA;
   PLACEBO-CONTROLLED TRIAL; ST-SEGMENT DEPRESSION; I-F INHIBITOR;
   VENTRICULAR SYSTOLIC DYSFUNCTION; CONVERTING ENZYME-INHIBITION
AB Ischemic heart disease (IHD) is the leading cause of death among women in Western countries, and it is associated with higher morbidity and mortality than in men. Nevertheless, IHD in women remains underdiagnosed and undertreated, and the misperception that females are "protected" against cardiovascular disease leads to underestimation of their cardiovascular risk; instead, women with chest pain have a high risk of cardiovascular events. Women suffering from angina pectoris tend to have different characteristics compared to men, with a high prevalence of non-significant coronary artery disease. Angina in women is more commonly microvascular in origin than in men, and therefore standard diagnostic algorithms may be suboptimal for women. This different pathophysiology impacts clinical management of IHD in women. While response to medical therapy may differ in women, they are scarcely represented in clinical trials. Therefore, solid data in terms of gender efficacy of antianginal drugs are lacking, and particularly when angina is microvascular in origin women often continue to be symptomatic despite maximal therapy with classical antianginal drugs. Recently, new molecules have shown promising results in women. In conclusion, women with angina are a group of patients in whom it seems appropriate to concentrate efforts aimed at reducing morbidity and improving quality of life. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
C1 [Zuchi, Cinzia; Tritto, Isabella; Ambrosio, Giuseppe] Univ Perugia, Sch Med, Dept Cardiol, I-06100 Perugia, Italy.
C3 University of Perugia
RP Ambrosio, G (corresponding author), Osped S Maria Misericordia, Dept Cardiol, Piazzale Menghini 1, I-06132 Perugia, Italy.
EM giuseppe.ambrosio@ospedale.perugia.it
RI Tritto, Isabella/Y-8881-2019; zuchi, cinzia/Y-9529-2019; Ambrosio,
   Giuseppe/JUV-2507-2023
OI Zuchi, Cinzia/0000-0003-3955-3879; TRITTO, Isabella/0000-0003-0026-7154;
   giuseppe, ambrosio/0000-0002-9677-980X
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NR 115
TC 26
Z9 26
U1 0
U2 11
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0167-5273
EI 1874-1754
J9 INT J CARDIOL
JI Int. J. Cardiol.
PD FEB 20
PY 2013
VL 163
IS 2
BP 132
EP 140
DI 10.1016/j.ijcard.2012.07.001
PG 9
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 086BP
UT WOS:000314658300013
PM 22824253
DA 2025-06-11
ER

PT J
AU Kawabata, N
   Kubo, I
   Suzuki, K
   Terai, T
   Iwama, T
   Isobe, M
AF Kawabata, N
   Kubo, I
   Suzuki, K
   Terai, T
   Iwama, T
   Isobe, M
TI 'Tako-tsubo cardiomyopathy' associated with syndrome malin - Reversible
   left ventricular dysfunction
SO CIRCULATION JOURNAL
LA English
DT Article
DE iodine-123(I-123) metaiodobenzylguanidine (MIBG) scintigraphy;
   microvascular abnormality; syndrome malin; tako-tsubo cardiomyopathy;
   Thallium-201 (Tl-201) myocardial scintigraphy
ID ST-SEGMENT ELEVATION; SYNDROME-X; AMPULLA CARDIOMYOPATHY; STUNNED
   MYOCARDIUM; ANGINA-PECTORIS; INNERVATION; SPASM
AB A 66-year-old man developed a fever and had a syncopal attack during treatment with imipramine and amantadine for depression and Parkinson's disease. His muscular enzyme levels were very high, so he was diagnosed with incomplete syndrome malin and given hydration therapy. The electrocardiogram recorded an ST segment elevation like acute myocardial infarction in most leads, and the echocardiogram revealed left ventricular dysfunction with severe hypokinesis to dyskinesis of the anterior and apical wall regions, and hyperkinesis of the basal wall. One month from onset, the left ventricular contractility had not changed despite normal coronary arteries. Thallium-201(Tl-201) myocardial scintigraphy showed a perfusion defect and there was no accumulation of iodine-123(I-123) metaiodobenzylguanidine (MIBG) in the entire apex of the heart. Left ventricular function returned to normal and repeat Tl-201 scintigraphy showed recovery by the 4th month. However, there was still an absence of cardiac MIBG uptake. There are a number of reports from Japan of a syndrome demonstrating such reversible left ventricular dysfunction, called 'tako-tsubo cardiomyopathy', but the present case is the first to be associated with syndrome malin. A coronary microvascular abnormality and cardiac sympathetic denervation probably both play an important role in tako-tsubo cardiomyopathy.
C1 Bokutou Metropolitan Hosp, Dept Cardiol, Tokyo, Japan.
   Tokyo Med & Dent Univ, Dept Cardiovasc Med, Tokyo, Japan.
C3 Institute of Science Tokyo; Tokyo Medical & Dental University (TMDU)
RP Yokohama Red Cross Hosp, Dept Cardiol, Naka Ku, 2-85 Negishi Cho, Yokohama, Kanagawa 2310836, Japan.
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NR 29
TC 22
Z9 24
U1 0
U2 1
PU JAPANESE CIRCULATION SOC
PI TOYKO
PA 18TH FLOOR IMPERIAL HOTEL TOWER, 1-1-1 UCHISAIWAI-CHO CHIYODA-KU, TOYKO,
   100-0011, JAPAN
SN 1346-9843
EI 1347-4820
J9 CIRC J
JI Circ. J.
PD AUG
PY 2003
VL 67
IS 8
BP 721
EP 724
PG 4
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 706FQ
UT WOS:000184443300017
PM 12890919
DA 2025-06-11
ER

PT J
AU de Courten, B
   Mousa, A
   Naderpoor, N
   Teede, H
   de Courten, MPJ
   Scragg, R
AF de Courten, Barbora
   Mousa, Aya
   Naderpoor, Negar
   Teede, Helena
   de Courten, Maximilian P. J.
   Scragg, Robert
TI Vitamin D supplementation for the prevention of type 2 diabetes in
   overweight adults: study protocol for a randomized controlled trial
SO TRIALS
LA English
DT Article
DE 25(OH)D; inflammation; insulin secretion; insulin sensitivity; type 2
   diabetes; vitamin D
ID BECK DEPRESSION INVENTORY; INSULIN-RESISTANCE; 1,25-DIHYDROXYVITAMIN
   D-3; 25-HYDROXYVITAMIN D; SUN EXPOSURE; GLUCOSE-HOMEOSTASIS; METABOLIC
   SYNDROME; HYPOVITAMINOSIS-D; D DEFICIENCY; D-RECEPTOR
AB Background: Despite Australia's sunny climate, low vitamin D levels are increasingly prevalent. Sun exposure is limited by long working hours, an increase in time spent indoors, and sun protection practices, and there is limited dietary vitamin D fortification. While the importance of vitamin D for bone mineralization is well known, its role as a protective agent against chronic diseases, such as type 2 diabetes and cardiovascular disease, is less understood. Observational and limited intervention studies suggest that vitamin D might improve insulin sensitivity and secretion, mainly via its anti-inflammatory properties, thereby decreasing the risk of development and progression of type 2 diabetes. The primary aim of this trial is to investigate whether improved plasma concentrations of 25-hydroxyvitamin D (25(OH)D), obtained through vitamin D supplementation, will increase insulin sensitivity and insulin secretion. A secondary aim is to determine whether these relationships are mediated by a reduction in underlying subclinical inflammation associated with obesity.
   Methods/Design: Fifty overweight but otherwise healthy nondiabetic adults between 18 and 60 years old, with low vitamin D levels (25(OH)D < 50 nmol/l), will be randomly assigned to intervention or placebo. At baseline, participants will undergo a medical review and anthropometric measurements, including dual X-ray absorptiometry, an intravenous glucose tolerance test, muscle and fat biopsies, a hyperinsulinemic euglycemic clamp, and questionnaires assessing diet, physical activity, sun exposure, back and knee pain, and depression. The intervention group will receive a first dose of 100,000 IU followed by 4,000 IU vitamin D (cholecalciferol) daily, while the placebo group will receive apparently identical capsules, both for a period of 16 weeks. All measurements will be repeated at follow-up, with the primary outcome measure expressed as a change from baseline in insulin sensitivity and secretion for the intervention group compared with the placebo group. Secondary outcome measures will compare changes in anthropometry, cardiovascular risk factors, and inflammatory markers.
   Discussion: The trial will provide much needed clinical evidence on the impact of vitamin D supplementation on insulin resistance and secretion and its underlying mechanisms, which are relevant for the prevention and management of type 2 diabetes.
C1 [de Courten, Barbora; Mousa, Aya; Naderpoor, Negar; Teede, Helena] Monash Univ, Monash Ctr Hlth Res & Implementat, Sch Publ Hlth & Prevent Med, Clayton, Vic 3186, Australia.
   [de Courten, Barbora; Mousa, Aya; Naderpoor, Negar] Monash Hlth, Diabet & Vasc Med Unit, Melbourne, Vic, Australia.
   [de Courten, Maximilian P. J.] Univ Victoria, Ctr Chron Dis, Melbourne, Vic, Australia.
   [Scragg, Robert] Univ Auckland, Sch Populat Hlth, Auckland 1, New Zealand.
C3 Monash University; Monash Health; Victoria University; University of
   Auckland
RP de Courten, B (corresponding author), Monash Univ, Monash Ctr Hlth Res & Implementat, Sch Publ Hlth & Prevent Med, 43-51 Kanooka Grove, Clayton, Vic 3186, Australia.
EM barbora.decourten@monash.edu
RI Mousa, Aya/AFU-5166-2022; Naderpoor, Negar/IUM-7706-2023; de Courten,
   Maximilian/B-3300-2012; de Courten, Barbora/B-3308-2012
OI Naderpoor, Negar/0000-0002-1738-3189; de Courten,
   Maximilian/0000-0001-9997-9359; Teede, Helena/0000-0001-7609-577X;
   Scragg, Robert/0000-0003-0013-2620; Mousa, Aya/0000-0002-7356-4523; de
   Courten, Barbora/0000-0001-8760-2511
FU National Health and Medical Research Council (NHMRC) [APP: 1047897];
   Monash University
FX BdC is a recipient of a National Health and Medical Research Council
   (NHMRC) grant which is funding the trial over the next 3 years (APP:
   1047897). AM is a recipient of the Australian Postgraduate Award
   Scholarship provided by Monash University. HT is an NHMRC Practitioner
   Research fellow.
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NR 75
TC 34
Z9 34
U1 2
U2 38
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1745-6215
J9 TRIALS
JI Trials
PD AUG 7
PY 2015
VL 16
AR 335
DI 10.1186/s13063-015-0851-6
PG 12
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA CO2JQ
UT WOS:000358982600001
PM 26246241
OA Green Accepted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Seppälä, J
   Koponen, H
   Kautiainen, H
   Eriksson, JG
   Kampman, O
   Leiviskä, J
   Männistö, S
   Mäntyselkä, P
   Oksa, H
   Ovaskainen, Y
   Viikki, M
   Vanhala, M
   Seppälä, J
AF Seppala, Jussi
   Koponen, Hannu
   Kautiainen, Hannu
   Eriksson, Johan G.
   Kampman, Olli
   Leiviska, Jaana
   Mannisto, Satu
   Mantyselka, Pekka
   Oksa, Heikki
   Ovaskainen, Yrj
   Viikki, Merja
   Vanhala, Mauno
   Seppala, Jussi
TI Association between vitamin b12 levels and melancholic
   depressive symptoms: a Finnish population-based study
SO BMC PSYCHIATRY
LA English
DT Article
DE Beck depression inventory; Melancholic depressive symptoms;
   Non-melancholic depressive symptoms; Population-based; Vitamin B-12
ID STRESSFUL LIFE EVENTS; METABOLIC SYNDROME; SERUM FOLATE; HOMOCYSTEINE;
   INVENTORY; HEALTH; WOMEN; OLDER; PREVALENCE; DEFICIENCY
AB Background: An association between vitamin B-12 levels and depressive symptoms (DS) has been reported in several epidemiological studies. The purpose of this study was to evaluate vitamin B-12 levels in population-based samples with melancholic or non-melancholic DS as the relationship between vitamin B-12 levels and different subtypes of DS has not been evaluated in previous studies.
   Methods: Subjects without previously known type 2 diabetes, aged 45-74 years were randomly selected from the National Population Register as a part of the Finnish diabetes prevention programme (FIN-D2D). The study population (N = 2806, participation rate 62%) consisted of 1328 men and 1478 women. The health examinations were carried out between October and December 2007 according to the WHO MONICA protocol. The assessment of DS was based on the Beck Depression Inventory (BDI, cut-off >= 10 points). A DSM-IV-criteria based summary score of melancholic items in the BDI was used in dividing the participants with DS (N = 429) into melancholic (N = 138) and non-melancholic DS (N = 291) subgroups. In the statistical analysis we used chi-squared test, t-test, permutation test, analysis of covariance, multivariate logistic regression analysis and multinomial regression model.
   Results: The mean vitamin B-12 level was 331 +/- 176 pmol/L in those without DS while the subjects with non-melancholic DS had a mean vitamin B-12 level of 324 +/- 135 pmol/L, and those with melancholic DS had the lowest mean vitamin B-12 level of 292 +/- 112 pmol/L (p < 0.001 after adjusted for age, sex, use of antidepressive medication and chronic diseases sum index). The adjusted difference of vitamin B-12 levels between the non-melancholic and the melancholic group was 33 pmol/ L (95% CI 8 to 57, p = 0.008). Melancholic DS and vitamin B-12 levels showed an independent linearly inverse association. The relative risk ratio (RRR) for melancholic DS was 2.75 (95% CI 1.66 to 4.56) in the lowest vitamin B-12 level tertile versus the highest (p for linearity < 0.001) when those without DS formed the reference group. The RRR in the non-melancholic subgroup was nonsignificant.
   Conclusions: The vitamin B-12 level was associated with melancholic DS but not with non-melancholic DS.
C1 [Seppala, Jussi; Seppala, Jussi] South Savo Hosp Dist, Dept Psychiat, Moisiontie 10, FIN-50520 Mikkeli, Finland.
   [Koponen, Hannu] Univ Eastern Finland, Dept Psychiat, Inst Clin Med, Kuopio, Finland.
   [Koponen, Hannu] Kuopio Univ Hosp, Dept Psychiat, SF-70210 Kuopio, Finland.
   [Kautiainen, Hannu; Vanhala, Mauno] Cent Finland Cent Hosp, Unit Family Practice, Jyvaskyla 40620, Finland.
   [Kautiainen, Hannu; Vanhala, Mauno] Kuopio Univ Hosp, Unit Primary Hlth Care, SF-70210 Kuopio, Finland.
   [Eriksson, Johan G.] Univ Helsinki, Dept Gen Practice & Primary Hlth Care, Helsinki, Finland.
   [Eriksson, Johan G.] Helsinki Univ Gen Hosp, Unit Gen Practice, Helsinki, Finland.
   [Eriksson, Johan G.; Leiviska, Jaana] Natl Inst Hlth & Welf, Helsinki, Finland.
   [Eriksson, Johan G.] Folkhalsan Res Ctr, Helsinki, Finland.
   [Eriksson, Johan G.] Vasa Cent Hosp, Vaasa 65130, Finland.
   [Kampman, Olli; Viikki, Merja] Univ Tampere, Sch Med, Tampere 33014, Finland.
   [Kampman, Olli] Seinajoki Hosp Dist, Dept Psychiat, Seinajoki 60220, Finland.
   [Mannisto, Satu] Natl Inst Hlth & Welf, Dept Chron Dis Prevent, Helsinki, Finland.
   [Mantyselka, Pekka] Univ Turku, Inst Clin Med, Turku 20014, Finland.
   [Mantyselka, Pekka] Turku Univ Hosp, Unit Primary Hlth Care, FIN-20520 Turku, Finland.
   [Oksa, Heikki] Tampere Univ Hosp, Tampere, Finland.
   [Viikki, Merja] Tampere Mental Hlth Ctr, Tampere, Finland.
C3 University of Eastern Finland; Kuopio University Hospital; University of
   Eastern Finland; University of Eastern Finland Hospital; Central Finland
   Central Hospital; Kuopio University Hospital; University of Eastern
   Finland; University of Eastern Finland Hospital; University of Helsinki;
   Finland National Institute for Health & Welfare; Folkhalsan Research
   Center; Vaasa Central Hospital; Tampere University; Finland National
   Institute for Health & Welfare; University of Turku; University of
   Turku; Tampere University; Tampere University Hospital
RP Seppälä, J (corresponding author), South Savo Hosp Dist, Dept Psychiat, Moisiontie 10, FIN-50520 Mikkeli, Finland.
EM jussi.seppala@esshp.fi
RI Gibbs, J. Raphael/A-3984-2010; Kampman, Olli/AAW-2352-2021
OI Eriksson, Johan/0000-0002-2516-2060; Kampman, Olli/0000-0001-6891-2266;
   Koponen, Hannu/0000-0002-7368-1869; Mannisto, Satu/0000-0002-8668-3046
FU hospital district of Pirkanmaa; hospital district of Southern
   Ostrobothnia; hospital district of North Ostrobothnia; hospital district
   of Central Finland; hospital district of Northern Savo; National
   Institute for Health and Welfare; Finnish Diabetes Association; Ministry
   of Social Affairs and Health in Finland; Finland's Slot Machine
   Association; FIN-D2D Study Group; Steering Committee
FX FIN-D2D was supported by funding from the hospital districts of
   Pirkanmaa, Southern Ostrobothnia, North Ostrobothnia, Central Finland
   and Northern Savo, the National Institute for Health and Welfare, the
   Finnish Diabetes Association, the Ministry of Social Affairs and Health
   in Finland and Finland's Slot Machine Association in cooperation with
   the FIN-D2D Study Group, and the Steering Committee: J. Huttunen, A.
   Kesaniemi, S. Kiuru, L. Niskanen, H. Oksa, J. Pihlajamaki, J. Puolakka,
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NR 51
TC 35
Z9 36
U1 0
U2 18
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-244X
J9 BMC PSYCHIATRY
JI BMC Psychiatry
PD MAY 24
PY 2013
VL 13
AR 145
DI 10.1186/1471-244X-13-145
PG 8
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 158XE
UT WOS:000320006500001
PM 23705786
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Lazzari, C
   Shoka, A
   Nusair, A
   Rabottini, M
AF Lazzari, Carlo
   Shoka, Ahmed
   Nusair, Abdul
   Rabottini, Marco
TI Weight gain and obesity in general adult psychiatric inpatients: a
   longitudinal and cross-sectional study
SO RIVISTA DI PSICHIATRIA
LA English
DT Article
DE obesity; weight gain; psychiatry; inpatients; Body Mass Index
ID DIET-INDUCED DYSBIOSIS; BODY-MASS INDEX; DISORDERS; ASSOCIATION;
   PREDICTORS; OVERWEIGHT; DEPRESSION; FOOD
AB Background. Weight gain and obesity are significantly linked to mental illness. There have been different theories trying to explain weight gain to psychiatric inpatients, such as physical inactivity and lifestyle, the effect of psychotropic drugs, increased food intake triggered by depression, and comorbidity between mental illness and obesity. The current research is a longitudinal and cross-sectional study collecting the electronic records of weight of psychiatric inpatients in a period spanning from one to ten years to address these theories. Methods. We collected the electronic records relative to weight measurement that are conducted weekly and relative to 240 non-forensic psychiatric inpatients (124 males and 116 females) and for a period from 1 to 10 years. Mean ages for males was 39.65 years (SD=+/- 11.66) and females 40.88 years (SD=+/- 13.73). They accessed a psychiatric inpatient service in the United Kingdom. The coefficient of determination R2 calculated the time variation in bodyweight in the period span, while the Chi-square statistic evaluated the differences in outcomes. Results. Our longitudinal study shows that R2=0.17 (95% CI=0.14-0.20) for males and 0.27 (95% CI=02.0-0.34) for females. There was a statistically significant difference between the R2 (chi(2): p<.05) for both genders. The average Body Mass Index (BMI) for male psychiatric inpatients was 27.05 (SD=+/- 5.92), corresponding to WHO Overweight Class. The average BMI for female psychiatric inpatients was instead 31.21 (SD=+/- 7.73), corresponding to WHO Obesity Class I. The difference in BMI was statistically significant for both genders (chi(2): p<.001). Discussion. In our study, only 27% of the difference in body weight in females and 17% in males was explainable by the time variable with a small to moderate effect size. Our findings appear to support the theory that overweight and morbid obesity might be comorbid with psychiatric illnesses and independent from the therapeutic regimen. Overall, females' BMI is more pathological. Conclusion. During lengthy admissions, only modest changes in body weight were observed in our research. Our findings would suggest that metabolic syndrome and therefore elevated BMI, overweight, and obesity might be comorbid with psychiatric illnesses and might be independent of the length of admissions.
C1 [Lazzari, Carlo; Rabottini, Marco] Int Ctr Healthcare & Med Educ ICHME, Dept Psychiat, Bristol, Avon, England.
   [Shoka, Ahmed] Essex Partnership Univ NHS Fdn Trust EPUT, Dept Gen Adult Psychiat, Colchester, Essex, England.
   [Nusair, Abdul] South West Yorkshire NHS Trust, Dept Psychiat, Wakefield, England.
RP Lazzari, C (corresponding author), Int Ctr Healthcare & Med Educ ICHME, Dept Psychiat, Bristol, Avon, England.
EM carlolazzari2015@gmail.com
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NR 55
TC 1
Z9 1
U1 0
U2 6
PU PENSIERO SCIENTIFICO EDITORE
PI ROME
PA VIA SAN GIOVANNI VALDARNO 8, ROME, ITALY
SN 0035-6484
EI 2038-2502
J9 RIV PSICHIATR
JI Riv. Psichiatr.
PD JUL-AUG
PY 2021
VL 56
IS 4
BP 211
EP 216
DI 10.1708/3654.36349
PG 6
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA TP8KO
UT WOS:000677843300006
PM 34310579
DA 2025-06-11
ER

PT J
AU Buvat, J
   Maggi, M
   Guay, A
   Torres, LO
AF Buvat, Jacques
   Maggi, Mario
   Guay, Andre
   Torres, Luiz Otavio
TI Testosterone Deficiency in Men: Systematic Review and Standard Operating
   Procedures for Diagnosis and Treatment
SO JOURNAL OF SEXUAL MEDICINE
LA English
DT Review
DE Testosterone Deficiency; Diagnosis; Testosterone Therapy; Prostate Risk;
   Cardiovascular Risk; Algorithm; Monitoring; Erectile Dysfunction; Male
   Hypoactive Sexual Desire; Delayed Ejaculation; Obesity; Diabetes;
   Metabolic Syndrome; Cardiovascular Diseases; Mortality; Body
   Composition; Osteoporosis; Frailty; Depression
ID LATE-ONSET HYPOGONADISM; LOW SERUM TESTOSTERONE; PLACEBO-CONTROLLED
   TRIAL; MIDDLE-AGED MEN; ANDROGEN DEPRIVATION THERAPY; ENDOGENOUS
   SEX-HORMONES; POPULATION-BASED COHORT; GASTRIC BYPASS-SURGERY;
   BONE-MINERAL DENSITY; CAG REPEAT LENGTH
AB Introduction. Testosterone (T) deficiency (TD) may significantly affect sexual function and multiple organ systems. Aim. To provide recommendations and Standard Operating Procedures (SOPs) based on best evidence for diagnosis and treatment of TD in men. Methods. Medical literature was reviewed by the Endocrine subcommittee of the ISSM Standards Committee, followed by extensive internal discussion over two years, then public presentation and discussion with other experts. Main Outcome Measure. Recommendations and SOPs based on grading of evidence-based medical literature and interactive discussion. Results. TD is the association of a low serum T with consistent symptoms or signs. T level tends to decline with age. T modulates sexual motivation and erection. It also plays a broader role in men's health. Recent studies have established associations between low T, male sexual dysfunctions and metabolic risk factors. Though association does not mean causation, low T is associated with reduced longevity, risk of fatal cardiovascular events, obesity, sarcopenia, mobility limitations, osteoporosis, frailty, cognitive impairment, depression, Sleep Apnea Syndrome, and other chronic diseases. The paper proposes a standardized process for diagnosis and treatment of TD, and updates the knowledge on T therapy (Tth) and prostate and cardiovascular safety. There is no compelling evidence that Tth causes prostate cancer or its progression in men without severe TD. Polycythemia is presently the only cardiovascular-related adverse-event significantly associated with Tth. But follow-up of controlled T trials is limited to 3 years. Conclusions. Men with sexual dysfunctions, and/or with visceral obesity and metabolic diseases should be screened for TD and treated. Young men with TD should also be treated. Benefits and risks of Tth should be carefully assessed in older men. Prospective, long-term, placebo-controlled, interventional studies are required before screening for TD in more conditions, including cardiovascular diseases, and considering correction of TD as preventive medicine. Buvat J, Maggi M, Guay A, and Torres LO. Testosterone deficiency in men: Systematic review and standard operating procedures for diagnosis and treatment. J Sex Med 2013;10:245-284.
C1 [Buvat, Jacques] CETPARP, F-59000 Lille, France.
   [Maggi, Mario] Univ Florence, Florence, Italy.
   [Guay, Andre] Lahey Clin Northshore, Ctr Sexual Funct Endocrinol, Peabody, MA USA.
   [Torres, Luiz Otavio] Clin Urol & Androl, Belo Horizonte, MG, Brazil.
C3 University of Florence; Lahey Hospital & Medical Center
RP Buvat, J (corresponding author), CETPARP, 3 Rue Carolus, F-59000 Lille, France.
EM jacques@buvat.org
RI Maggi, Mario/AAB-8284-2019
OI MAGGI, Mario/0000-0003-3267-4221
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NR 196
TC 196
Z9 209
U1 1
U2 94
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1743-6095
EI 1743-6109
J9 J SEX MED
JI J. Sex. Med.
PD JAN
PY 2013
VL 10
IS 1
BP 245
EP 284
DI 10.1111/j.1743-6109.2012.02783.x
PG 40
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 076UV
UT WOS:000313984900020
PM 22971200
DA 2025-06-11
ER

PT J
AU Leissing-Desprez, C
   Thomas, E
   Segaux, L
   Broussier, A
   Oubaya, N
   Marie-Nelly, N
   Laurent, M
   de Langavant, LC
   Fromentin, I
   David, JP
   Bastuji-Garin, S
AF Leissing-Desprez, Claire
   Thomas, Emilie
   Segaux, Lauriane
   Broussier, Amaury
   Oubaya, Nadia
   Marie-Nelly, Nathalie
   Laurent, Marie
   de Langavant, Laurent Cleret
   Fromentin, Isabelle
   David, Jean-Philippe
   Bastuji-Garin, Sylvie
TI Understated Cognitive Impairment Assessed with the Clock-Drawing Test in
   Community-Dwelling Individuals Aged ≥50 Years
SO JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
LA English
DT Article
DE Understated cognitive impairment; Clock-Drawing Test; screening;
   middle-aged; elderly
ID PREDICTS LONGITUDINAL CHANGES; ALZHEIMERS-DISEASE; GAIT SPEED; EXECUTIVE
   FUNCTION; TEST-PERFORMANCE; EPISODIC MEMORY; OLDER-PEOPLE; DEMENTIA;
   FRAILTY; HEALTH
AB Objectives: To estimate the prevalence of understated cognitive impairment by administering the Clock-Drawing Test (CDT) to community-dwelling individuals aged >= 50 years and to investigate the associated clinical phenotype.
   Design: A cross-sectional analysis of baseline data on community-dwelling individuals assessed at an outpatient clinic in the Paris region of France.
   Setting and Participants: Participants aged >= 50 years (n = 488, median age: 62.1 years) prospectively included in the SUCCessful agEing outpatiEnt's Department survey between 2010 and 2014.
   Methods: A multidimensional geriatric assessment, including cognition [7-point CDT, Mini-Mental State Examination (MMSE), the 5-word screening test (5-WT), and the Frontal Assessment Battery (FAB)], gait speed in dual tasks, mood [the Geriatric Depression Scale (GDS)], balance, physical functions (gait speed and handgrip strength), nutrition, bone density, and comorbidities; major cardiovascular risk factors, and Scheltens and Fazekas scores on brain magnetic resonance imaging. Baseline characteristics were analyzed as a function of the CDT score (<7 vs 7), using age-adjusted logistic models.
   Results: The prevalence of impairment in the CDT was 23.6%; higher than the values for the MMSE (12.7%), 5-WT (2.3%), and FAB (16.6%). In age-adjusted analyses, a lower educational level (odds ratio [95% confidence interval] = 0.72 [0.58-0.89]), diabetes (2.57 [1.14-5.79]), metabolic syndrome (1.93 [1.05-3.56]), lower gait speed in the cognitive dual task (1.27 [1.05-1.53]), a poorer Geriatric Depression Scale score (1.86 [1.04-3.32]), a poorer MMSE score (2.56 [1.35-4.88]), a poorer FAB score (1.79 [1.01-3.16]), impaired episodic memory in the 5-WT (4.11 [1.12-15.02]), and a higher Scheltens score (P = .001) were significantly associated with CDT impairment.
   Conclusions and Implications: Understated cognitive impairment is common among young seniors and is associated with factors known to be linked to a higher risk of cognitive decline and dementia. These findings suggest that the CDT may be of value for identifying high-risk individuals who may then benefit from targeted multidomain prevention actions (diet, exercise, cognitive training, and vascular risk factor management). (C) 2020 AMDA - The Society for Post-Acute and Long-Term Care Medicine.
C1 [Leissing-Desprez, Claire; Segaux, Lauriane; Broussier, Amaury; Oubaya, Nadia; Laurent, Marie; David, Jean-Philippe; Bastuji-Garin, Sylvie] Univ Paris Est Creteil, CEpiA Team, IMRB, INSERM, Creteil, France.
   [Leissing-Desprez, Claire; Thomas, Emilie; Broussier, Amaury; Marie-Nelly, Nathalie; Laurent, Marie; Fromentin, Isabelle; David, Jean-Philippe] Hop Henri Mondor, AP HP, Dept Geriatr Med, Creteil, France.
   [Segaux, Lauriane; Bastuji-Garin, Sylvie] Hop Henri Mondor, AP HP, Clin Res Unit URC Mondor, Creteil, France.
   [Oubaya, Nadia; Bastuji-Garin, Sylvie] Hop Henri Mondor, AP HP, Dept Publ Hlth, Creteil, France.
   [de Langavant, Laurent Cleret] Hop Henri Mondor, AP HP, Dept Neurol, Creteil, France.
   [de Langavant, Laurent Cleret] PSL Res Univ, NeuroPsychol Intervent, IMRB, INSERM U955 E01, Creteil, France.
   [de Langavant, Laurent Cleret] PSL Res Univ, NeuroPsychol Intervent, ENS DEC, Creteil, France.
   [de Langavant, Laurent Cleret] PSL Res Univ, NeuroPsychol Intervent, IMRB, INSERM U955 E01, Paris, France.
   [de Langavant, Laurent Cleret] PSL Res Univ, NeuroPsychol Intervent, ENS DEC, Paris, France.
C3 Institut National de la Sante et de la Recherche Medicale (Inserm);
   Universite Paris-Est-Creteil-Val-de-Marne (UPEC); Universite
   Paris-Est-Creteil-Val-de-Marne (UPEC); Assistance Publique Hopitaux
   Paris (APHP); Hopital Universitaire Henri-Mondor - APHP; Assistance
   Publique Hopitaux Paris (APHP); Universite
   Paris-Est-Creteil-Val-de-Marne (UPEC); Hopital Universitaire
   Henri-Mondor - APHP; Assistance Publique Hopitaux Paris (APHP);
   Universite Paris-Est-Creteil-Val-de-Marne (UPEC); Hopital Universitaire
   Henri-Mondor - APHP; Universite Paris-Est-Creteil-Val-de-Marne (UPEC);
   Assistance Publique Hopitaux Paris (APHP); Hopital Universitaire
   Henri-Mondor - APHP; Institut National de la Sante et de la Recherche
   Medicale (Inserm); Universite PSL; Universite
   Paris-Est-Creteil-Val-de-Marne (UPEC); Universite PSL; Institut National
   de la Sante et de la Recherche Medicale (Inserm); Universite
   Paris-Est-Creteil-Val-de-Marne (UPEC); Universite PSL; Universite PSL
RP Leissing-Desprez, C (corresponding author), Univ Paris Est Creteil, CEpiA Team, IMRB, INSERM, Creteil, France.
EM claire.leissing@aphp.fr
RI Oubaya, Nadia/R-3301-2018; Laurent, Marie/R-4468-2018; Broussier,
   Amaury/KBP-8951-2024; David, Juceni/AAX-8782-2020; Bastuji-Garin,
   Sylvie/R-3479-2018
OI BROUSSIER, Amaury/0000-0003-1137-9864
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NR 46
TC 8
Z9 9
U1 0
U2 15
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1525-8610
EI 1538-9375
J9 J AM MED DIR ASSOC
JI J. Am. Med. Dir. Assoc.
PD NOV
PY 2020
VL 21
IS 11
BP 1658
EP 1664
DI 10.1016/j.jamda.2020.03.016
PG 7
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA OL4LP
UT WOS:000585314000029
PM 32387111
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Schinke, C
   Hesse, S
   Stoppe, M
   Meyer, K
   Schmidt, E
   Orthgiess, J
   Bechmann, L
   Bresch, A
   Rullmann, M
   Luthardt, J
   Sabri, O
   Blüher, M
   Kratzsch, J
   Bergh, FT
AF Schinke, Christian
   Hesse, Swen
   Stoppe, Muriel
   Meyer, Klara
   Schmidt, Elisa
   Orthgiess, Johannes
   Bechmann, Lukas
   Bresch, Anke
   Rullmann, Michael
   Luthardt, Julia
   Sabri, Osama
   Blueher, Matthias
   Kratzsch, Juergen
   Bergh, Florian Then
TI Post-dexamethasone serum copeptin corresponds to HPA axis responsiveness
   in human obesity
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE Copeptin; HPA axis; Neuroendocrinology; Obesity; Dexamethasone crh test
ID PITUITARY-ADRENAL AXIS; POLYCYSTIC-OVARY-SYNDROME; ARGININE-VASOPRESSIN;
   METABOLIC SYNDROME; MULTIPLE-SCLEROSIS; INSULIN-RESISTANCE;
   DIABETES-MELLITUS; ABDOMINAL OBESITY; MAJOR DEPRESSION; FAT DISTRIBUTION
AB Context: Increased activities of the arginine-vasopressin (AVP) system and the hypothalamic-pituitary adrenal (HPA) axis were shown to be associated with human obesity, but relationships between these systems in obesity remain unclear.
   Objectives: To assess HPA axis responsiveness and its relation to serum concentrations of the AVP-surrogate copeptin in subjects with obesity (OB) in comparison to non-obesity controls (NOC).
   Methods: In a cross-sectional monocentric study, thirty-nine OB (f/m 25/14; age 36.5 +/- 10.0 years; body mass index, BMI, 41.5 +/- 4.7 kg/m(2)) were compared to twenty-two NOC 12/10; age 35.3 +/- 8.5 years; BMI 23.1 +/- 2.4 kg/m(2)), matched for age and sex. All individuals underwent the combined dexamethasone/CRH test. Main outcome measures: Plasma ACTH and cortisol curve indicators derived from the dex/CRH test (post-CRH concentrations 30 min after 100 mu g CRH; maximum concentration, MAX; area-under-the-curve, AUC; ACTH/cortisol ratios). Copeptin was assessed in 1500 h samples of the dex/CRH test (after 1.5 mg of oral dexamethasone, prior to CRH administration).
   Results: Copeptin serum concentrations were higher in OB (median [IQR]: OB 4.62 [2.60-5.88] vs. NOC 3.04 [2.52-4.29] pmol/1, P=0.04). Correspondingly, OB showed higher post-CRH cortisol concentrations (OB: 51.5 [25.9-159.3] vs. NOC: 28.6 [20.0-41.6] nmol/1, P = 0.01) and a lower post-CRH ACTH/cortisol ratio (OB: 0.028 [0.016-0.053] vs. NOC: 0.048 [0.034-0.070] pmol/nmol, P < 0.01). Serum copeptin was significantly associated with HPA responsiveness in OB (post-CRH ACTH: R = 0.42, P < 0.01), driven by OB men (post-CRH ACTH: R=0.76, P < 0.01, post-CRH cortisol: R=0.64, P=0.02). All associations withstand adjustments for BMI and age.
   Conclusions: The association between increased copeptin with ACTH and cortisol release suggests a potential mechanistic interaction of the AVP system with HPA activation in human obesity. The relation of copeptin and HPA responsiveness should be further validated in situations with pronounced HPA activation, such as depression or multiple sclerosis. (C) 2017 Elsevier Ltd. All rights reserved.
C1 [Schinke, Christian; Stoppe, Muriel; Meyer, Klara; Schmidt, Elisa; Orthgiess, Johannes; Bechmann, Lukas; Bergh, Florian Then] Univ Leipzig, Dept Neurol, Leipzig, Germany.
   [Hesse, Swen; Bresch, Anke; Rullmann, Michael; Luthardt, Julia; Sabri, Osama] Univ Leipzig, Dept Nucl Med, Leipzig, Germany.
   [Schinke, Christian; Hesse, Swen; Rullmann, Michael; Sabri, Osama; Blueher, Matthias] Univ Leipzig, Integrated Res & Treatment Ctr Adipos Dis, Leipzig, Germany.
   [Stoppe, Muriel; Bergh, Florian Then] Univ Leipzig, Translat Ctr Regenerat Med, Leipzig, Germany.
   [Blueher, Matthias] Univ Leipzig, Dept Med, Leipzig, Germany.
   [Kratzsch, Juergen] Univ Hosp Leipzig, Inst Lab Med Clin Chem & Mol Diagnost, Leipzig, Germany.
   [Bechmann, Lukas] Otto von Guericke Univ, Inst Med Microbiol, Magdeburg, Germany.
C3 Leipzig University; Leipzig University; Leipzig University; Leipzig
   University; Leipzig University; Leipzig University; Otto von Guericke
   University
RP Bergh, FT (corresponding author), Univ Leipzig, Klin & Poliklin Neurol, Liebigstr 20, D-04103 Leipzig, Germany.
EM ThenBerF@medizin.uni-leipzig.de
OI Hesse, Swen/0000-0002-2055-2764; Sabri, Osama/0000-0002-6425-3504;
   McLeod, Anke/0000-0003-3534-4738; Rullmann, Michael/0000-0002-2683-9432;
   Schinke, Christian/0000-0003-0199-9672
FU German Federal Ministry of Education and Research (BMBF)
FX This work was supported by the German Federal Ministry of Education and
   Research (BMBF).
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NR 57
TC 9
Z9 9
U1 1
U2 5
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD APR
PY 2017
VL 78
BP 39
EP 47
DI 10.1016/j.psyneuen.2017.01.004
PG 9
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA ER5UD
UT WOS:000398867900006
PM 28167369
DA 2025-06-11
ER

PT J
AU Matteucci, E
   Giampietro, O
AF Matteucci, E.
   Giampietro, O.
TI Building a bridge between clinical and basic research: The phenotypic
   elements of familial predisposition to type 1 diabetes
SO CURRENT MEDICINAL CHEMISTRY
LA English
DT Review
DE type 1 diabetes; family; diabetic nephropathy; inflammation; oxidative
   stress; immunomodulatory mechanisms; sodium/hydrogen exchange;
   erythrocyte electron transfer; lifestyle
ID SODIUM-LITHIUM COUNTERTRANSPORT; OXIDATIVE STRESS; NA+/H+ EXCHANGER;
   OXIDANT STRESS; STORAGE TIME; RED-CELLS; NA+/LI+ COUNTERTRANSPORT;
   CARDIOVASCULAR-DISEASE; ESSENTIAL-HYPERTENSION; HYDROGEN EXCHANGE
AB Familial aggregation has been shown for type 1 diabetes (T1D) although the nature of the factors (environment and/or genetics) responsible remains unclear. Familial clustering of diabetic nephropathy as well as of increased cardiovascular morbidity and early mortality has also been observed.
   This review describes the nearly 20 years history of our investigation in parallel with contemporary literature. The story is presented from the early years' strong focus on possible markers of T1D nephropathy (urinary albumin, urinary enzymes, erythrocyte Na/Li countertransport, and erythrocyte Na/H exchange) to the last clinical investigations to determine relevant biological markers of familial predisposition to T1D. Our studies of case-families recruited unaffected first-degree relatives of sporadic T1D cases and population-based controls. Unlike multiple-case families, these families are those less likely to carry a strong genetic predisposition. Participants were both interviewed and provided biological material for a detailed functional characterisation of their biochemical phenotype. These studies have initially excluded that the erythrocyte Na/H exchange could be a marker of diabetic nephropathy. On the contrary, NHE activity was significantly higher in T1D family members independently of the presence of renal disease. Basic science knowledge of NHE and its functional implications have also been reviewed. Unexpectedly, we found evidence of increased oxidative stress in nondiabetic normotensive relatives of T1D patients, apart from soluble markers of autoimmunity and despite seemingly intact antioxidant defences. Markers of oxidation were associated with markers of inflammation and we concluded that the familial increase in NHE activity could be ascribed to the direct stimulatory effect of oxidative stress.
   Relatives showed also immunological hallmarks and cardiovascular abnormalities that were related to indices of oxidative stress and metabolic syndrome. Other peculiarities emerged from measuring the erythrocytes redox system that exports electrons across the cell membrane to external oxidants as a function of cytoplasmic electron donor concentration. This electron transfer might reflect the functional state of membrane proton pumps that modulate intracellular redox levels. The transport system contributed to oxidation in T1D families, whereas in healthy people it protected from oxidation. Furthermore, dietary intake of vitamin C and sporting activities modulated erythrocyte electron transfer efficiency.
   The contribution of environmental factors was investigated using the European Prospective Investigation of Cancer and Nutrition questionnaires that provided evidence of common unhealthy dietary behaviours, which could even predispose to the development of diabetes and cardiovascular complications, in subjects living in Pisa. However, lifestyle of T1D relatives was indistinguishable from those of controls, except for the higher daily intake of niacin and the lower physical activity levels. No difference in smoking or alcohol consumption emerged among families and controls.
   The oxidative stress is a non-specific though certain component of pathogenesis at numerous diseases states of aerobic organisms. Although molecular genetic analysis has produced significant progress in T1D phenotype, much remains to be learned about the molecular sequence of events leading from a generic familial pro-oxidant background to a sporadic form of T1D (where oxidative damage targets the insulin-secreting cells).
C1 Univ Pisa, Dept Internal Med, I-56126 Pisa, Italy.
C3 University of Pisa
RP Matteucci, E (corresponding author), Univ Pisa, Dept Internal Med, Via Roma 67, I-56126 Pisa, Italy.
EM ematteuc@int.med.unipi.it
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NR 101
TC 5
Z9 5
U1 0
U2 5
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 0929-8673
EI 1875-533X
J9 CURR MED CHEM
JI Curr. Med. Chem.
PY 2007
VL 14
IS 5
BP 555
EP 567
DI 10.2174/092986707780059689
PG 13
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Pharmacology &
   Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
GA 133IW
UT WOS:000244007600005
PM 17346147
DA 2025-06-11
ER

PT J
AU Soriano, BM
   Güemes, A
   Pola, G
   Gonzalo, A
   Gasós, PP
   Navarro, AC
   Martínez-Beamonte, R
   Osada, J
   García, JJ
AF Martinez Soriano, Blanca
   Guemes, Antonio
   Pola, Guillermo
   Gonzalo, Azucena
   Palacios Gasos, Pilar
   Navarro, Ana C.
   Martinez-Beamonte, Roberto
   Osada, Jesus
   Garcia, Jose J.
TI Effect of Melatonin as an Antioxidant Drug to Reverse Hepatic Steatosis:
   Experimental Model
SO CANADIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
LA English
DT Article
ID FATTY LIVER-DISEASE; VITAMIN-E; NONALCOHOLIC STEATOHEPATITIS; TREATMENT
   IMPROVES; METABOLIC SYNDROME; DIET; FIBROSIS; PLACEBO
AB Introduction. The hepatic steatosis of the nonalcoholic origin or NAFLD is increasing at present, particularly in Western countries, parallel to the increase in obesity, constituting one of the most prevalent hepatic processes in the Western society. Melatonin has been successfully tested in experimental models in mice as a drug capable of reversing steatosis. The effect of melatonin on fat metabolism can be summarized as a decrease in lipid peroxidation and a decrease in oxidative stress, biochemical phenomena intimately related to fat deposition in the hepatocyte. There are hardly any studies in large animals.Objective. In this study, we investigate the effects of melatonin administered orally at a dose of 10 mg/kg/day to reverse established hepatic steatosis induced by a special diet in a porcine animal model.Materials and Methods. We analyze the parameters of oxidative stress: malondialdehyde (MDA), 4-hydroxyalkenals (4-HDA), and carbonyls, degree of fat infiltration (analyzed by direct vision by a pathologist and by means of a computer program of image treatment), and serological parameters of lipid metabolism and hepatic damage. These parameters were analyzed in animals to which hepatic steatosis was induced by means of dietary modifications.Results. We have not been able to demonstrate globally a beneficial effect of melatonin in the improvement or reversal of liver steatosis once established, induced by diet in a porcine animal model. However, we have found several signs of improvement at the histological level, at the level of lipid metabolism, and at the level of oxidative stress parameters. We have verified in our study that, in the histological analysis of the liver sample by means of the program image treatment (free of subjectivity) of the animals that continue with the diet, those that consume melatonin do not increase steatosis as much as those that do not consume it significantly (p=0.002). Regarding the parameters of oxidative stress, MDA modifies in a significant manner within the group of animals that continue with the diet and take melatonin (p=0.004). As for lipid metabolism, animals that maintain the steatotic diet and take melatonin lower total and LDL cholesterol levels and increase HDL levels, although these results do not acquire statistical significance.Conclusions. In this study, it has not been possible to demonstrate a beneficial effect of melatonin in the improvement or reversal of liver steatosis once established and induced by diet in the porcine model. It is true that signs of improvement have been found at the histological level, at the level of lipid metabolism, and at the level of oxidative stress phenomena, when comparing animals with established steatosis that are treated with melatonin with those who do not take it. This work is the first study conducted in a large animal model in which the effect of melatonin is studied as a treatment in the reversal of established hepatic steatosis.
C1 [Martinez Soriano, Blanca; Guemes, Antonio; Gonzalo, Azucena; Palacios Gasos, Pilar; Navarro, Ana C.] Univ Hosp Lozano Blesa, Dept Surg, Zaragoza, Spain.
   [Pola, Guillermo] Gen Def Hosp, Dept Surg, Zaragoza, Spain.
   [Martinez-Beamonte, Roberto] CIBER Biomed Net Invest Ctr Obes & Nutr Physiopat, Madrid, Spain.
   [Osada, Jesus] Univ Zaragoza, Dept Biochem & Mol & Cellular Biol, Zaragoza, Spain.
   [Garcia, Jose J.] Univ Zaragoza, Dept Physiol, Zaragoza, Spain.
C3 Lozano Blesa University Clinical Hospital; University of Zaragoza;
   University of Zaragoza
RP Soriano, BM (corresponding author), Univ Hosp Lozano Blesa, Dept Surg, Zaragoza, Spain.
EM blancamartine19@hotmail.com
RI Rosales, Juan/GZA-4531-2022; Martinez Beamonte, Roberto/E-4981-2016
OI Garcia Garcia, Jose Joaquin/0000-0001-9507-6478; Martinez Beamonte,
   Roberto/0000-0002-8100-5596
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NR 45
TC 9
Z9 8
U1 0
U2 4
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2291-2789
EI 2291-2797
J9 CAN J GASTROENTEROL
JI Can. J. Gastroenterol. Hepatol.
PD JUN 5
PY 2020
VL 2020
AR 7315253
DI 10.1155/2020/7315253
PG 12
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA MB3UF
UT WOS:000542529800001
PM 32566547
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Ozay, R
   Uzar, E
   Aktas, A
   Uyar, ME
   Gürer, B
   Evliyaoglu, O
   Cetinalp, NE
   Turkay, C
AF Ozay, Rafet
   Uzar, Ertugrul
   Aktas, Abit
   Uyar, Mehtap Erkmen
   Gurer, Bora
   Evliyaoglu, Osman
   Cetinalp, Nuri Eralp
   Turkay, Cansel
TI The role of oxidative stress and inflammatory response in high-fat diet
   induced peripheral neuropathy
SO JOURNAL OF CHEMICAL NEUROANATOMY
LA English
DT Article
DE High-fat diet; Inflammation; Neuropathy; Oxidative stress
ID RAT SCIATIC-NERVE; DIABETIC-NEUROPATHY; INSULIN-RESISTANCE;
   ADIPOSE-TISSUE; LIPID-PEROXIDATION; METABOLIC SYNDROME; OBESE MICE;
   MECHANISMS; DISEASE; COMPLICATIONS
AB Objective: Earlier studies suggest that high-calorie diet is an important risk factor for neuronal damage resulting from oxidative stress of lipid metabolism. In our experimental study of rats under high-fat diet, oxidative stress markers and axonal degeneration parameters were used to observe the sciatic nerve neuropathy. The aim of this study is to evaluate the pathophysiology of neuropathy induced by high-fat diet.
   Methods: A total of 14 male rats (Wistar albino) were randomly divided into two experimental groups as follows; control group (n = 7) and the model group (n = 7); while control group was fed with standard diet; where the model group was fed with a high-fat diet for 12 weeks. At the end of 12 weeks, the lipid profile and blood glucose levels, interleukin-1 beta (IL-1), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), and transforming growth factor-beta (TGF-beta) levels were studied. Tissue malondialdehyde (MDA), nitric oxide (NO) levels and super-oxide dismutase (SOD), paraoxonase-1 (PON-1) and glutathione peroxidase (GPx) activities were studied. The distal blocks of the left sciatic nerves were evaluated for histomorphological analysis (including mean axon area, axon numbers, nerve fiber diameters, axon diameters, and thickness of myelin sheets).
   Results: Body weights, serum glucose and high-density lipoprotein (HDL) levels of rats were found not statistically significantly different compared between the model and the control groups (p > 0.05). Serum cholesterol, triglyceride, TGF-beta and TNF-alpha levels were significantly higher in the model group when compared with the control group (p < 0.05). IL-1 and IL-6 levels were not statistically significantly different compared between the model group and the control group (p > 0.05). The MDA and NO levels and the SOD and GPx activities of the sciatic nerves in model group were statistically significantly higher than the control group (p < 0.05). In addition, the activities of PON-1 were statistically significantly lower in the model group when compared with the control group (p < 0.05). The difference in the total number of myelinated axons between the control group and the model group was not statistically significant (p > 0.05). The nerve fiber diameter and the thickness of the myelin sheet were statistically significantly lower in the model group when compared with the control group (p < 0.05). The axon diameter and area were significantly decreased in the model group when compared with the control group (p < 0.05).
   Conclusion: Our results support that dyslipidemia is an independent risk factor for the development of neuropathy. In addition, we postulated that oxidative stress and inflammatory response may play an important role in the pathogenesis of high-fat diet induced neuropathy. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Ozay, Rafet; Gurer, Bora] Diskapi Yildirim Beyazit Educ & Res Hosp, Minist Hlth, Neurosurg Clin, Ankara, Turkey.
   [Uzar, Ertugrul] Dicle Univ, Dept Neurol, Sch Med, Diyarbakir, Turkey.
   [Aktas, Abit] Istanbul Univ, Fac Vet Med, Dept Histol & Embriol, Istanbul, Turkey.
   [Uyar, Mehtap Erkmen] Baskent Univ, Sch Med, Dept Nephrol, TR-06490 Ankara, Turkey.
   [Evliyaoglu, Osman] Dicle Univ, Dept Biochem, Sch Med, Diyarbakir, Turkey.
   [Cetinalp, Nuri Eralp] Etlik Ihtisas Res & Educ Hosp, Dept Neurosurg, Ankara, Turkey.
   [Turkay, Cansel] Fatih Univ, Dept Gastroenterol, Sch Med, Ankara, Turkey.
C3 Ministry of Health - Turkey; Diskapi Yildirim Beyazit Training &
   Research Hospital; Dicle University; Istanbul University; Baskent
   University; Dicle University; Ankara Etlik Ihtisas Egitim ve Arastirma
   Hastanesi; Fatih University
RP Gürer, B (corresponding author), SB Diskapi Yildirim Beyazit Egitim & Arastirma Ha, Irfan Bastug Cad, Ankara, Turkey.
EM boragurer@gmail.com
RI Akdoğan, Mehtap/IAO-2608-2023; AKTAS, ABİT/D-1634-2019; Evliyaoglu,
   Osman/AAJ-1225-2020; Gurer, Bora/K-1177-2012; Ozay, Rafet/LZH-1815-2025;
   Cetinalp, Nuri Eralp/V-5918-2018
OI AKTAS, ABIT/0000-0003-1883-0021; Gurer, Bora/0000-0003-1500-6184; Ozay,
   Rafet/0000-0001-5982-4897; Cetinalp, Nuri Eralp/0000-0002-1008-9171;
   Evliyaoglu, Osman/0000-0002-5780-9068
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NR 73
TC 21
Z9 24
U1 0
U2 25
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0891-0618
EI 1873-6300
J9 J CHEM NEUROANAT
JI J. Chem. Neuroanat.
PD JAN
PY 2014
VL 55
BP 51
EP 57
DI 10.1016/j.jchemneu.2013.12.003
PG 7
WC Biochemistry & Molecular Biology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Neurosciences & Neurology
GA AE5DD
UT WOS:000334007100006
PM 24407112
DA 2025-06-11
ER

PT J
AU Jansen, MAC
   Uiterwaal, CSPM
   Visseren, FLJ
   van der Ent, CK
   Grobbee, DE
   Dalmeijer, GW
AF Jansen, Maria A. C.
   Uiterwaal, Cuno S. P. M.
   Visseren, Frank L. J.
   van der Ent, Cornelis K.
   Grobbee, Diederick E.
   Dalmeijer, Geertje W.
TI Abdominal fat and blood pressure in healthy young children
SO JOURNAL OF HYPERTENSION
LA English
DT Article
DE children; fat distribution; SBP and DBP; sitting and supine body
   posture; subcutaneous adipose tissue; visceral adipose tissue
ID CARDIOVASCULAR RISK-FACTORS; SUBCUTANEOUS ADIPOSE-TISSUE; BODY-FAT;
   CARDIOMETABOLIC RISK; PARENTAL SMOKING; OXIDATIVE STRESS;
   SEX-DIFFERENCES; OBESITY; ASSOCIATION; OVERWEIGHT
AB Objectives: High blood pressure (BP) and obesity are well known risk factors for cardiovascular diseases. Both risk factors exert an influence early in life, and BP is related to body weight. However, the effect of abdominal fat accumulation on BP in childhood is still unclear. We aimed to determine the relation between visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT) and BP in young children.
   Methods: In 862 healthy 5-year-old children of the Wheezing-Illnesses-Study-Leidsche-Rijn birth cohort, VAT and SAT were measured ultrasonographically. SBP and DBP were measured in sitting and supine postures using a semi -automatic oscillometric device. General linear regression analyses were performed to assess associations between abdominal fat and BP adjusted for confounders. Further explanatory models were run to explore if associations with localized abdominal fat distributions were independent of measures of overall body adiposity.
   Results: Each millimeter increase in VAT was related to 0.17 mmHg (95% confidence interval: 0.08; 0.3) and 0.11 mmHg (0.02; 0.2) higher sitting SBP and DBP, respectively. These associations remained after additional adjustment for BMI (SBP: 0.14 mmHg/mm, 0.05; 0.2; DBP: 0.11 mmHg/mm, 0.02; 0.2), waist circumference (SBP: 0.16 mmHg/mm, 0.06; 0.3; DBP: 0,12 mmHg/mm, 0.03; 0.2) or early life growth (SBP: 0.16 mmHg/mm, 0.07; 0.3; DBP: 0.115 mmHg/mm, 0.03; 0.2). Associations between VAT and supine SBP and DBP were, respectively, 0.14 mmHg/mm (0.06; 0.2) and 0.08 mmHg/mm (0.004; 0.2), which remained after further explanatory analyses. SAT was not associated to SBP or DBP.
   Conclusion: Independent of body size, children with more VAT have higher BP, especially when measured in sitting posture.
C1 [Jansen, Maria A. C.; Uiterwaal, Cuno S. P. M.; Grobbee, Diederick E.; Dalmeijer, Geertje W.] Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Wilhelmina Childrens Hosp, Utrecht, Netherlands.
   [Visseren, Frank L. J.] Univ Med Ctr Utrecht, Dept Vasc Med, Wilhelmina Childrens Hosp, Utrecht, Netherlands.
   [van der Ent, Cornelis K.] Univ Med Ctr Utrecht, Dept Paediat Pulmonol, Wilhelmina Childrens Hosp, Utrecht, Netherlands.
C3 Utrecht University; Utrecht University Medical Center; Wilhelmina
   Kinderziekenhuis; Wilhelmina Kinderziekenhuis; Utrecht University;
   Utrecht University Medical Center; Wilhelmina Kinderziekenhuis; Utrecht
   University; Utrecht University Medical Center
RP Dalmeijer, GW (corresponding author), Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, STR 6-131,POB 85500, NL-3508 GA Utrecht, Netherlands.
EM G.W.Dalmeijer@umcutrecht.nl
RI van der Schouw, Yvonne/F-8327-2014; Visseren, Frank/I-4855-2013;
   Grobbee, Diederick/C-7651-2014
OI Visseren, Frank/0000-0003-3951-5223; Van der Ent,
   Cornelis/0000-0002-2501-4121
FU Netherlands Organization for Health Research and Development
   [2001-1-1322]; Glaxo Smith Kline Netherlands; University Medical Center
   Utrecht (UMCU), The Netherlands
FX The WHISTLER birth cohort was supported with a grant from the
   Netherlands Organization for Health Research and Development (grant nr
   2001-1-1322) and by an unrestricted grant from Glaxo Smith Kline
   Netherlands. WHISTLER-Cardio was supported with an unrestricted
   strategic grant from the University Medical Center Utrecht (UMCU), The
   Netherlands.
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NR 64
TC 11
Z9 11
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0263-6352
EI 1473-5598
J9 J HYPERTENS
JI J. Hypertens.
PD SEP
PY 2016
VL 34
IS 9
BP 1796
EP 1803
DI 10.1097/HJH.0000000000000996
PG 8
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA DS6CX
UT WOS:000380870400016
PM 27341439
DA 2025-06-11
ER

PT J
AU Siervo, M
   Lara, J
   Chowdhury, S
   Ashor, A
   Oggioni, C
   Mathers, JC
AF Siervo, Mario
   Lara, Jose
   Chowdhury, Shakir
   Ashor, Ammar
   Oggioni, Clio
   Mathers, John C.
TI Effects of the Dietary Approach to Stop Hypertension (DASH) diet on
   cardiovascular risk factors: a systematic review and meta-analysis
SO BRITISH JOURNAL OF NUTRITION
LA English
DT Review
DE Dietary Approach to Stop Hypertension diet; Meta-analyses; Hypertension;
   Dyslipidaemia; Diabetes; Cardiovascular risk
ID BLOOD-PRESSURE RESPONSE; OXIDATIVE STRESS; EATING PLAN; MEDITERRANEAN
   DIET; CLINICAL-TRIAL; WEIGHT-LOSS; SODIUM; DISEASE; EXERCISE;
   INFLAMMATION
AB The Dietary Approach to Stop Hypertension (DASH) is recommended to lower blood pressure (BP), but its effects on cardiometabolic biomarkers are unclear. A systematic review and meta-analysis of randomised controlled trials (RCT) was conducted to determine the effects of the DASH diet on cardiovascular risk factors. Medline, Embase and Scopus databases were searched from inception to December 2013. Inclusion criteria were as follows: (1) DASH diet; (2) RCT; (3) risk factors including systolic and diastolic BE and glucose, HDL, LDL, TAG and total cholesterol concentrations; (4) control group. Random-effects models were used to determine the pooled effect sizes. Meta-regression analyses were carried out to examine the association between effect sizes, baseline values of the risk factors, BMI, age, quality of trials, salt intake and study duration. A total of twenty articles reporting data for 1917 participants were included in the meta-analysis. The duration of interventions ranged from 2 to 21 weeks. The DASH diet was found to result in significant decreases in systolic BP (-5.2mmHg, 95% CI -7.0, -3.4; P<0.001) and diastolic BP (-2.6 mmHg, 95% CI -3.5, -1.7; P<0.001) and in the concentrations of total cholesterol (-0.20 mmol/l, 95% CI -0.31, -0.10; P<0.001) and LDL (-0.10 mmol/l, 95% CI -0.20, -0.01; P=0.03). Changes in both systolic and diastolic BP were greater in participants with higher baseline BP or BMI. These changes predicted a reduction of approximately 13% in the 10-year Framingham risk,score for CVD. The DASH diet improved cardiovascular risk factors and appeared to have greater beneficial effects in subjects with an increased cardiometabolic risk. The DASH diet is an effective nutritional strategy to prevent CVD.
C1 [Siervo, Mario; Lara, Jose; Chowdhury, Shakir; Ashor, Ammar; Oggioni, Clio; Mathers, John C.] Newcastle Univ, Inst Cellular Med, Human Nutr Res Ctr, Newcastle Upon Tyne NE4 5PL, Tyne & Wear, England.
   [Ashor, Ammar] Univ Al Mustansiriyah, Coll Med, Baghdad, Iraq.
C3 Newcastle University - UK; Mustansiriya University
RP Siervo, M (corresponding author), Newcastle Univ, Inst Cellular Med, Human Nutr Res Ctr, Campus Ageing & Vital, Newcastle Upon Tyne NE4 5PL, Tyne & Wear, England.
EM mario.siervo@ncl.ac.uk
RI Mathers, Jonathan/ABE-1164-2021; Siervo, Mario/AAB-9302-2019; Ashor,
   Ammar Waham/A-9094-2013
OI Lara, Jose/0000-0002-4449-9304; Ashor, Ammar Waham/0000-0002-0826-5471;
   Mathers, John/0000-0003-3406-3002; Siervo, Mario/0000-0001-5515-0944
FU Ministry of Higher Education and Scientific Research of Iraq; LiveWell
   Programme through Lifelong Health and Wellbeing initiative;
   Biotechnology and Biological Sciences Research Council; Engineering and
   Physical Sciences Research Council; Economic and Social Research
   Council; Medical Research Council; Chief Scientist Office of the
   Scottish Government Health Directorates; National Institute for Health
   Research/The Department of Health; Health and Social Care Research &
   Development of the Public Health Agency (Northern Ireland); Wales Office
   of Research and Development for Health and Social Care; Welsh Assembly
   Government [G0900686]; MRC [G0900686] Funding Source: UKRI
FX A. A. received funds from the Ministry of Higher Education and
   Scientific Research of Iraq. J. L. and J. C. M. acknowledge support
   received from the LiveWell Programme, a research project funded through
   a collaborative grant from the Lifelong Health and Wellbeing initiative,
   managed by the Medical Research Council on behalf of the following
   funders: Biotechnology and Biological Sciences Research Council;
   Engineering and Physical Sciences Research Council; Economic and Social
   Research Council; Medical Research Council; Chief Scientist Office of
   the Scottish Government Health Directorates; National Institute for
   Health Research/The Department of Health; The Health and Social Care
   Research & Development of the Public Health Agency (Northern Ireland);
   Wales Office of Research and Development for Health and Social Care and
   the Welsh Assembly Government (grant no. G0900686).
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NR 49
TC 329
Z9 375
U1 12
U2 75
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1145
EI 1475-2662
J9 BRIT J NUTR
JI Br. J. Nutr.
PD JAN 14
PY 2015
VL 113
IS 1
BP 1
EP 15
DI 10.1017/S0007114514003341
PG 15
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA AX7OM
UT WOS:000347105000001
PM 25430608
OA Bronze
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Zamani, M
   Kelishadi, MR
   Ashtary-Larky, D
   Amirani, N
   Goudarzi, K
   Torki, IA
   Bagheri, R
   Ghanavati, M
   Asbaghi, O
AF Zamani, Mohammad
   Kelishadi, Mahnaz Rezaei
   Ashtary-Larky, Damoon
   Amirani, Niusha
   Goudarzi, Kian
   Torki, Iman Attackpour
   Bagheri, Reza
   Ghanavati, Matin
   Asbaghi, Omid
TI The effects of green tea supplementation on cardiovascular risk factors:
   A systematic review and meta-analysis
SO FRONTIERS IN NUTRITION
LA English
DT Review
DE green tea supplementation; cardiovascular risk factors; systematic
   review; meta-analysis; lipid profile; glycemic control; blood pressure
ID RANDOMIZED CONTROLLED-TRIAL; TYPE-2 DIABETES-MELLITUS; C-REACTIVE
   PROTEIN; BLOOD-PRESSURE; LIPID PROFILE; DOUBLE-BLIND; OXIDATIVE STRESS;
   INSULIN-RESISTANCE; BODY-WEIGHT; DIETARY SUPPLEMENTATION
AB PurposeA bulk of observational studies have revealed the protective role of green tea supplementation in cardiovascular diseases. The current systematic review and meta-analysis study aimed to establish the effects of green tea supplementation on cardiovascular risk factors including lipid profile, blood pressure, glycemic control markers and CRP. MethodsA systematic literature search of randomized clinical trials (RCTs) that investigated the effects of green tea supplementation and cardiovascular risk factors was undertaken in online databases including PubMed/Medline, Scopus, Web of Science, and Embase using a combination of green tea and cardiovascular risk factors search terms. Meta-analyses were carried out using a random-effects model. The I-2 index was used to assess the heterogeneity of RCTs. ResultsAmong the initial 11,286 studies that were identified from electronic databases search, 55 eligible RCTs with 63 effect sizes were eligible. Results from the random effects meta-analysis showed that GTE supplementation significantly reduced TC (WMD = -7.62; 95% CI: -10.51, -4.73; P = < 0.001), LDL-C (WMD = -5.80; 95% CI: -8.30, -3.30; P = < 0.001), FBS (WMD = -1.67; 95% CI: -2.58, -0.75; P = < 0.001), HbA1c (WMD = -0.15; 95% CI: -0.26, -0.04; P = 0.008), DBP (WMD = -0.87; 95% CI: -1.45, -0.29; P = 0.003), while increasing HDL-C (WMD = 1.85; 95% CI: 0.87, 2.84; P = 0.010). Subgroup analyses based on the duration of supplementation (>= 12 vs. < 12 weeks), dose of green tea extract (GTE) (>= 1,000 vs. < 1,000 mg/d), sex (male, female, and both), baseline serum levels of lipid profile, and glycemic control factors demonstrated different results for some risk factors. ConclusionThe current study suggests improvements in the lipid and glycemic profiles following green tea supplementation. These findings support previous evidence showing the health benefits of green tea supplementation on cardiometabolic risk factors.
C1 [Zamani, Mohammad] Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Clin Nutr, Tehran, Iran.
   [Kelishadi, Mahnaz Rezaei] Isfahan Univ Med Sci, Sch Nutr & Food Sci, Dept Community Nutr, Esfahan, Iran.
   [Ashtary-Larky, Damoon] Ahvaz Jundishapur Univ Med Sci, Nutr & Metab Dis Res Ctr, Ahvaz, Iran.
   [Amirani, Niusha] Alborz Univ Med Sci, Fac Med, Tehran, Iran.
   [Goudarzi, Kian] Shahid Beheshti Univ Med Sci, Fac Med, Tehran, Iran.
   [Torki, Iman Attackpour] Golestan Univ Med Sci, Fac Med, Gorgan, Iran.
   [Bagheri, Reza] Univ Isfahan, Dept Exercise Physiol, Esfahan, Iran.
   [Ghanavati, Matin] Shahid Beheshti Univ Med Sci, Natl Nutr & Food Technol Res Inst, Fac Nutr Sci & Food Technol, Tehran, Iran.
   [Asbaghi, Omid] Shahid Beheshti Univ Med Sci, Canc Res Ctr, Tehran, Iran.
   [Asbaghi, Omid] Shahid Beheshti Univ Med Sci, Student Res Comm, Tehran, Iran.
C3 Tehran University of Medical Sciences; Isfahan University of Medical
   Sciences; Ahvaz Jundishapur University of Medical Sciences (AJUMS);
   Alborz University of Medical Sciences; Shahid Beheshti University
   Medical Sciences; Golestan University of Medical Sciences; University of
   Isfahan; Shahid Beheshti University Medical Sciences; Shahid Beheshti
   University Medical Sciences; Shahid Beheshti University Medical Sciences
RP Ghanavati, M (corresponding author), Shahid Beheshti Univ Med Sci, Natl Nutr & Food Technol Res Inst, Fac Nutr Sci & Food Technol, Tehran, Iran.; Asbaghi, O (corresponding author), Shahid Beheshti Univ Med Sci, Canc Res Ctr, Tehran, Iran.; Asbaghi, O (corresponding author), Shahid Beheshti Univ Med Sci, Student Res Comm, Tehran, Iran.
EM matinghanavati@sbmu.ac.ir; omid.asbaghi@gmail.com
RI Ashtary Larky, Damoon/T-4192-2019; Ghanavati, Matin/AAD-6617-2022
OI Attackpour Torik, Iman/0009-0001-7563-8004; Ashtary Larky,
   Damoon/0000-0001-7968-6110; Zamani, Mohammad/0000-0002-3853-023X
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NR 130
TC 18
Z9 18
U1 1
U2 12
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD JAN 10
PY 2023
VL 9
AR 1084455
DI 10.3389/fnut.2022.1084455
PG 30
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 8F6XL
UT WOS:000919803800001
PM 36704803
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU de Giorgis, T
   Marcovecchio, ML
   Di Giovanni, I
   Giannini, C
   Chiavaroli, V
   Chiarelli, F
   Mohn, A
AF de Giorgis, Tommaso
   Marcovecchio, M. Loredana
   Di Giovanni, Ilaria
   Giannini, Cosimo
   Chiavaroli, Valentina
   Chiarelli, Francesco
   Mohn, Angelika
TI Triglycerides-to-HDL ratio as a new marker of endothelial dysfunction in
   obese prepubertal children
SO EUROPEAN JOURNAL OF ENDOCRINOLOGY
LA English
DT Article
ID INTIMA-MEDIA THICKNESS; CARDIOMETABOLIC RISK-FACTORS;
   INSULIN-RESISTANCE; CHOLESTEROL RATIO; CHILDHOOD OBESITY; CARDIOVASCULAR
   RISK; DYSLIPIDEMIA; ASSOCIATION; ADOLESCENTS; ULTRASOUND
AB Objective: To investigate whether there is an association of the triglyceride-to-HDL cholesterol (TG:HDL-C) ratio with cardiovascular risk factors and early signs of vascular damage in obese prepubertal children.
   Design and methods: In 50 obese (27 boys, 7.8 +/- 1.4 years) and 37 normal-weight (20 boys; 7.3 +/- 1.5 years) prepubertal children, anthropometric measurements, oxidative stress markers (urinary isoprostanes (PGF2 alpha (prostaglandin F2 alpha)), soluble receptor for advanced glycation end-products (sRAGE)) and insulin sensitivity (homeostasis model assessment of insulin resistance (HOMA-IR) and whole-body insulin sensitivity index (WBISI)) were evaluated. Lipids profile was assessed and the TG: HDL-C ratio was calculated. In addition, high-resolution ultrasound was performed to assess carotid intima-media thickness (cIMT).
   Results: Obese children showed significantly higher values of the TG: HDL-C ratio (1.9 +/- 1.1 vs 1.2 +/- 0.6, P=0.002) compared with controls. After dividing the population in tertiles of the TG:HDL-C ratio (<1.04, 1.04-1.67, >1.67), cIMT (P=0.0003), and HOMA-IR (P=0.0001) progressively increased from the lower to the upper tertile, whereas WBISI (P=0.0003) and sRAGE (P=0.05) progressively decreased. In a regression model, the TG:HDL ratio was significantly and positively associated with cIMT (r=0.493; P=0.0005). A cutoff point for TG:HDL-C ratio of 1.12 had 81% sensitivity and 49% specificity in the identification of children with cIMT values in the upper quartile (Area under the curve values from receiver operating characteristic curves=0.633 +/- 0.065, P=0.045).
   Conclusion: This study confirms the reliability of the TG:HDL-C ratio as a useful marker of cardiovascular risk. Interestingly, our results underline that the TG:HDL-C ratio is directly related with early signs of vascular damage already present in prepubertal children.
C1 [de Giorgis, Tommaso; Marcovecchio, M. Loredana; Di Giovanni, Ilaria; Giannini, Cosimo; Chiavaroli, Valentina; Chiarelli, Francesco; Mohn, Angelika] Univ G dAnnunzio, Osped Policlin, Dept Pediat, I-66100 Chieti, Italy.
   [de Giorgis, Tommaso; Marcovecchio, M. Loredana; Giannini, Cosimo; Chiavaroli, Valentina; Chiarelli, Francesco; Mohn, Angelika] Univ G dAnnunzio, Clin Res Ctr, I-66100 Chieti, Italy.
C3 G d'Annunzio University of Chieti-Pescara; G d'Annunzio University of
   Chieti-Pescara
RP Mohn, A (corresponding author), Univ G dAnnunzio, Osped Policlin, Dept Pediat, Via Vestini 5, I-66100 Chieti, Italy.
EM amohn@unich.it
RI Chiavaroli, Valentina/ABB-1911-2020; Giannini, Cosimo/K-9631-2016
OI Chiavaroli, Valentina/0000-0003-0555-2173; Maria Loredana,
   Marcovecchio/0000-0002-4415-316X; Giannini, Cosimo/0000-0002-2904-2744
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NR 27
TC 52
Z9 56
U1 0
U2 2
PU BIOSCIENTIFICA LTD
PI BRISTOL
PA EURO HOUSE, 22 APEX COURT WOODLANDS, BRADLEY STOKE, BRISTOL BS32 4JT,
   ENGLAND
SN 0804-4643
EI 1479-683X
J9 EUR J ENDOCRINOL
JI Eur. J. Endocrinol.
PD FEB
PY 2014
VL 170
IS 2
BP 173
EP 180
DI 10.1530/EJE-13-0452
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA AA9DW
UT WOS:000331395000007
PM 24165018
OA Bronze
DA 2025-06-11
ER

PT J
AU Elumn, JE
   Saeed, GJ
   Aminawung, J
   Horton, N
   Lin, HJ
   Yaggi, HK
   Wang, EA
AF Elumn, Johanna E.
   Saeed, Gul Jana
   Aminawung, Jenerius
   Horton, Nadine
   Lin, Hsiu-Ju
   Yaggi, H. Klar
   Wang, Emily A.
TI The sleep justice study - a prospective cohort study assessing sleep as
   a cardiometabolic risk factor after incarceration: a protocol paper
SO BMC PUBLIC HEALTH
LA English
DT Article
DE Incarceration; Sleep; Cardiovascular risk; Prospective cohort
ID POSTTRAUMATIC-STRESS-DISORDER; PRISON POPULATIONS; QUALITY INDEX;
   INSOMNIA; HEALTH; DURATION; PREVALENCE; ADULTS; HYPERTENSION;
   DISPARITIES
AB BackgroundAn estimated 11 million individuals are released from U.S. jails and prisons each year. Individuals with a history of incarceration have higher rates of cardiovascular disease (CVD) events and mortality compared to the general population, especially in the weeks following release from carceral facilities. Healthy sleep, associated with cardiovascular health, is an underexplored factor in the epidemiology of CVD in this population. Incarcerated people may have unique individual, environmental, and institutional policy-level reasons for being sleep deficient. The social and physical environment within carceral facilities and post-release housing may synergistically affect sleep, creating disparities in sleep and cardiovascular health. Since carceral facilities disproportionately house poor and minoritized groups, population-specific risk factors that impact sleep may also contribute to inequities in cardiovascular outcomes.MethodsThis study is ancillary to an ongoing prospective cohort recruiting 500 individuals with known cardiovascular risk factors within three months of release from incarceration, the Justice-Involved Individuals Cardiovascular Disease Epidemiology (JUSTICE) study. The Sleep Justice study will measure sleep health among participants at baseline and six months using three validated surveys: the Pittsburgh Sleep Quality Index (PSQI), the STOP-Bang, and the Brief Index of Sleep Control. In a subsample of 100 individuals, we will assess sleep over the course of one week using wrist actigraphy, a validated objective measure of sleep that collects data on rest-activity patterns, sleep, and ambient light levels. Using this data, we will estimate and compare sleep health and its association with CVD risk factor control in individuals recently released from carceral facilities.DiscussionThe incarceration of millions of poor and minoritized groups presents an urgent need to understand how incarceration affects CVD epidemiology. This study will improve our understanding of sleep health among people released from carceral facilities and its potential relationship to CVD risk factor control. Using subjective and objective measures of sleep will allow us to identify unique targets to improve sleep health and mitigate cardiovascular risk in an otherwise understudied population.
C1 [Elumn, Johanna E.; Aminawung, Jenerius; Horton, Nadine; Wang, Emily A.] Yale Sch Med, SEICHE Ctr Hlth & Justice, New Haven, CT 06510 USA.
   [Elumn, Johanna E.; Aminawung, Jenerius; Horton, Nadine; Wang, Emily A.] Yale Sch Med, Dept Internal Med, Sect Gen Internal Med, New Haven, CT 06510 USA.
   [Saeed, Gul Jana] Roger Williams Med Ctr, Dept Internal Med, Providence, RI USA.
   [Lin, Hsiu-Ju] Univ Connecticut, Sch Social Work, Storrs, CT USA.
   [Yaggi, H. Klar] Yale Sch Med, Dept Internal Med, Sect Pulm Crit Care & Sleep Med, New Haven, CT USA.
   [Yaggi, H. Klar] VA CT Clin Epidemiol Res Ctr CERC, West Haven, CT USA.
C3 Yale University; Yale University; Roger Williams Medical Center;
   University of Connecticut; Yale University
RP Elumn, JE (corresponding author), Yale Sch Med, SEICHE Ctr Hlth & Justice, New Haven, CT 06510 USA.; Elumn, JE (corresponding author), Yale Sch Med, Dept Internal Med, Sect Gen Internal Med, New Haven, CT 06510 USA.
EM johanna.elumn@yale.edu
FU This publication was made possible by Grant Number 3R01HL137696-03S1
   from the National Heart, Lung, and Blood Institute (NHLBI) and CTSA
   Grant Number KL2 TR001862 from the National Center for Advancing
   Translational Science (NCATS), components of the Natio
   [3R01HL137696-03S1]; National Heart, Lung, and Blood Institute (NHLBI)
   [KL2 TR001862]; CTSA; National Center for Advancing Translational
   Science (NCATS), components of the National Institutes of Health (NIH)
FX This publication was made possible by Grant Number 3R01HL137696-03S1
   from the National Heart, Lung, and Blood Institute (NHLBI) and CTSA
   Grant Number KL2 TR001862 from the National Center for Advancing
   Translational Science (NCATS), components of the National Institutes of
   Health (NIH). Its contents are solely the responsibility of the authors
   and do not necessarily represent the official views of NIH.
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NR 61
TC 1
Z9 1
U1 1
U2 3
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2458
J9 BMC PUBLIC HEALTH
JI BMC Public Health
PD OCT 27
PY 2023
VL 23
IS 1
AR 2107
DI 10.1186/s12889-023-16985-x
PG 7
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA W3FV9
UT WOS:001090529200001
PM 37884957
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Han, YS
   Liu, Y
   Zhao, ZY
   Zhen, SH
   Chen, JH
   Ding, N
   Ma, YN
   Wen, DL
AF Han, Yanshuo
   Liu, Yang
   Zhao, Zhongyi
   Zhen, Shihan
   Chen, Jianhua
   Ding, Ning
   Ma, Yanan
   Wen, Deliang
TI Does Physical Activity-Based Intervention Improve Systemic
   Proinflammatory Cytokine Levels in Overweight or Obese Children and
   Adolescents? Insights from a Meta-Analysis of Randomized Control Trials
SO OBESITY FACTS
LA English
DT Review
DE Pediatric obesity; Exercise therapy; Adolescent; Exercise physiology;
   Inflammation mediators; Physical fitness
ID C-REACTIVE PROTEIN; CARDIOMETABOLIC RISK-FACTORS; INFLAMMATORY MARKERS;
   CARDIOVASCULAR RISK; LIFE-STYLE; ENDOTHELIAL FUNCTION; INSULIN
   SENSITIVITY; OXIDATIVE STRESS; BODY-COMPOSITION; EXERCISE
AB Objectives: The purpose of this research was to conduct a meta-analysis of the role that physical activity (PA) plays in influencing the critical proinflammatory cytokine levels associated with overweight/obese children and adolescents to explore the effectiveness of exercise intervention within this population. Methods: With searches of the PubMed, EMBASE, and CENTRAL databases, we updated our meta-analysis up to November 2018. The randomized controlled trials (RCT) evaluated the ability of exercise training to increase the following factors in children and/or adolescents classified as obese or overweight: tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, and C-reactive protein (CRP). Results: Eleven RCT comprising 623 children and/or adolescents who were obese or overweight (i.e., 393 with PA and 230 controls) were suitable for use in this study. The meta-analysis showed that PA in general was associated with a significant reduction of CRP levels (mean difference = -0.45 mg/L, p = 0.02) in overweight/obese children and adolescents. Based on 115 overweight and obese youths, this study suggests that PA does not significantly mitigate IL-6 levels (mean difference = -0.39 pg/mL, p = 0.08), although there was a trend towards a reduction. Additionally, no close connection was observed between PA and TNF-alpha levels at 0.04 pg/mL (p = 0.78). Moreover, meta-regression analysis revealed a statistical association between CPR levels and changes in BMI or changes in adiponectin; likewise, IL-6 levels dramatically impacted the effect of exercise on changes in adiponectin. Conclusions: PA was associated with significantly reduced CRP levels, whereas there was no significant association with IL-6 or TNF-alpha in overweight/obese children or adolescents; however, there was a trend towards a reduction of IL-6.
C1 [Han, Yanshuo; Liu, Yang; Zhao, Zhongyi; Zhen, Shihan; Chen, Jianhua; Ma, Yanan; Wen, Deliang] China Med Univ, Inst Hlth Sci, Shenyang, Liaoning, Peoples R China.
   [Han, Yanshuo] China Med Univ, Shengjing Hosp, Dept Gen Surg, Shenyang, Liaoning, Peoples R China.
   [Chen, Jianhua] China Med Univ, Shengjing Hosp, 2 Orthoped Dept, Shenyang, Liaoning, Peoples R China.
   [Ding, Ning; Wen, Deliang] China Med Univ, Res Ctr Med Educ, Shenyang, Liaoning, Peoples R China.
   [Ma, Yanan] China Med Univ, Sch Publ Hlth, Shenyang, Liaoning, Peoples R China.
C3 China Medical University; China Medical University; China Medical
   University; China Medical University; China Medical University
RP Wen, DL (corresponding author), China Med Univ, Inst Hlth Sci, Shenyang North New Area, 77 Puhe Rd, Shenyang 110122, Liaoning, Peoples R China.
EM dlwen@cmu.edu.cn
RI Chen, Jianhuachen/JFA-7960-2023; Han, Yanshuo/ACW-0969-2022
OI Han, Yanshuo/0000-0002-4897-2998
FU China Postdoctoral Science Foundation [2018M640270]; National Science
   Foundation of China [71774173, 81600370]; Natural Science Foundation of
   Liaoning Province of China [20180530007]
FX This work was supported by the China Postdoctoral Science Foundation
   (grant 2018M640270), the National Science Foundation of China (grant
   71774173 and grant 81600370), and the Natural Science Foundation of
   Liaoning Province of China (grant 20180530007).
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NR 60
TC 23
Z9 26
U1 3
U2 20
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1662-4025
EI 1662-4033
J9 OBESITY FACTS
JI Obes. Facts
PD DEC
PY 2019
VL 12
IS 6
BP 653
EP 668
DI 10.1159/000501970
PG 16
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA JZ6AJ
UT WOS:000505183500006
PM 31645033
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Liu, A
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   Channon, Keith M.
   Jerosch-Herold, Michael
   Piechnik, Stefan K.
   Neubauer, Stefan
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TI RETRACTED: Diagnosis of Microvascular Angina Using Cardiac Magnetic
   Resonance (Retracted article. See vol. 76, pg. 1916, 2020)
SO JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
LA English
DT Article; Retracted Publication
DE cardiac magnetic resonance; index of microcirculatory resistance;
   inducible ischemia; microvascular dysfunction; myocardial perfusion
   reserve index
ID CORONARY-ARTERY-DISEASE; FRACTIONAL FLOW RESERVE; MICROCIRCULATORY
   RESISTANCE; ADENOSINE-STRESS; MYOCARDIAL-PERFUSION; PROGNOSTIC VALUE;
   SYNDROME-X; INDEX; OXYGENATION; DYSFUNCTION
AB BACKGROUND In patients with angina and nonobstructive coronary artery disease (NOCAD), confirming symptoms due to coronary microvascular dysfunction (CMD) remains challenging. Cardiac magnetic resonance (CMR) assesses myocardial perfusion with high spatial resolution and is widely used for diagnosing obstructive coronary artery disease (CAD).
   OBJECTIVES The goal of this study was to validate CMR for diagnosing microvascular angina in patients with NOCAD, compared with patients with obstructive CAD and correlated to the index of microcirculatory resistance (IMR) during invasive coronary angiography.
   METHODS Fifty patients with angina (65 +/- 9 years of age) and 20 age-matched healthy control subjects underwent adenosine stress CMR (1.5- and 3-T) to assess left ventricular function, inducible ischemia (myocardial perfusion reserve index [MPRI]; myocardial blood flow [MBF]), and infarction (late gadolinium enhancement). During subsequent angiography within 7 days, 28 patients had obstructive CAD (fractional flow reserve [FFR] <= 0.8) and 22 patients had NOCAD (FFR >0.8) who underwent 3-vessel IMR measurements.
   RESULTS In patients with NOCAD, myocardium with IMR <25 U had normal MPRI (1.9 +/- 0.4 vs. controls 2.0 +/- 0.3; p = 0.49); myocardium with IMR >= 25 U had significantly impaired MPRI, similar to ischemic myocardium downstream of obstructive CAD (1.2 +/- 0.3 vs. 1.2 +/- 0.4; p = 0.61). An MPRI of 1.4 accurately detected impaired perfusion related to CMD (IMR >= 25 U; FFR >0.8) (area under the curve: 0.90; specificity: 95%; sensitivity: 89%; p < 0.001). Impaired MPRI in patients with NOCAD was driven by impaired augmentation of MBF during stress, with normal resting MBF. Myocardium with FFR >0.8 and normal IMR (< 25 U) still had blunted stress MBF, suggesting mild CMD, which was distinguishable from control subjects by using a stress MBF threshold of 2.3 ml/min/g with 100% positive predictive value.
   CONCLUSIONS In angina patients with NOCAD, CMR can objectively and noninvasively assess microvascular angina. A CMR-based combined diagnostic pathway for both epicardial and microvascular CAD deserves further clinical validation. (c) 2018 The Authors. Published by Elsevier on behalf of the AmericanCollege of Cardiology Foundation. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
C1 [Liu, Alexander; Wijesurendra, Rohan S.; Liu, Joanna M.; Piechnik, Stefan K.; Neubauer, Stefan; Ferreira, Vanessa M.] Univ Oxford, Div Cardiovasc Med, Radcliffe Dept Med, Oxford Ctr Clin Magnet Resonance Res, Oxford, England.
   [Forfar, John C.] John Radcliffe Hosp, Oxford Heart Ctr, Oxford, England.
   [Channon, Keith M.; Kharbanda, Rajesh K.] Univ Oxford, Div Cardiovasc Med, Radcliffe Dept Med, Oxford, England.
   [Jerosch-Herold, Michael] Brigham & Womens Hosp, Radiol, Cardiovasc Imaging, 75 Francis St, Boston, MA 02115 USA.
C3 University of Oxford; University of Oxford; University of Oxford;
   Harvard University; Harvard University Medical Affiliates; Brigham &
   Women's Hospital
RP Ferreira, VM (corresponding author), Univ Oxford, John Radcliffe Hosp, Oxford Ctr Clin Magnet Resonance Res, Div Cardiovasc Med,Radcliffe Dept Med, Oxford OX3 9DU, England.
EM vanessa.ferreira@cardiov.ox.ac.uk
RI Kharbanda, Rajesh/ACK-0990-2022; Neubauer, Stefan/B-8448-2011;
   Jerosch-Herold, Michael/R-9824-2019
OI channon, keith/0000-0002-1043-4342; Neubauer,
   Stefan/0000-0001-9017-5645; Piechnik, Stefan K./0000-0002-0268-5221
FU British Heart Foundation Clinical Research Training Fellowship
   [FS/15/11/31233]; National Institute for Health Research Biomedical
   Research Centre; British Heart Foundation Centre of Research Excellence
   [RE/08/004]
FX This study and Dr. Liu were funded by a British Heart Foundation
   Clinical Research Training Fellowship grant (FS/15/11/31233). Drs.
   Ferreira, Wijesurendra, Piechnik, and Neubauer are supported by the
   National Institute for Health Research Biomedical Research Centre. Drs.
   Wijesurendra, Neubauer, Piechnik, and Ferreira acknowledge support from
   the British Heart Foundation Centre of Research Excellence (RE/08/004).
   All other authors have reported that they have no relationships relevant
   to the contents of this paper to disclose. Drs. Kharbanda and Ferreira
   contributed equally to this work and are joint senior authors.
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NR 32
TC 98
Z9 103
U1 0
U2 8
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0735-1097
EI 1558-3597
J9 J AM COLL CARDIOL
JI J. Am. Coll. Cardiol.
PD MAR 6
PY 2018
VL 71
IS 9
BP 969
EP 979
DI 10.1016/j.jacc.2017.12.046
PG 11
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA FX6GT
UT WOS:000426182300002
PM 29495996
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Chen, JC
   Goodrich, JA
   Walker, DI
   Liao, JW
   Costello, E
   Alderete, TL
   Valvi, D
   Hampson, H
   Li, SW
   Baumert, BO
   Rock, S
   Jones, DP
   Eckel, SP
   McConnell, R
   Gilliland, FD
   Aung, MT
   Conti, DV
   Chen, ZH
   Chatzi, L
AF Chen, Jiawen Carmen
   Goodrich, Jesse A.
   Walker, Douglas I.
   Liao, Jiawen
   Costello, Elizabeth
   Alderete, Tanya L.
   Valvi, Damaskini
   Hampson, Hailey
   Li, Shiwen
   Baumert, Brittney O.
   Rock, Sarah
   Jones, Dean P.
   Eckel, Sandrah P.
   McConnell, Rob
   Gilliland, Frank D.
   Aung, Max T.
   Conti, David V.
   Chen, Zhanghua
   Chatzi, Lida
TI Exposure to per- and polyfluoroalkyl substances and high-throughput
   proteomics in Hispanic youth
SO ENVIRONMENT INTERNATIONAL
LA English
DT Article
DE Per-and polyfluoroalkyl substances (PFAS); Proteomics; Cardiometabolic;
   Inflammation; Immune response
ID PROTEIN-TYROSINE-PHOSPHATASE; BONE TURNOVER MARKERS; OSTEOGENIC
   DIFFERENTIATION; PERFLUOROALKYL SUBSTANCES; CARDIOMETABOLIC RISK;
   INSULIN-RESISTANCE; PUBERTAL CHANGES; DENDRITIC CELLS; ASSOCIATION;
   POPULATION
AB Background: Strong epidemiological evidence shows positive associations between exposure to per- and polyfluoroalkyl substances (PFAS) and adverse cardiometabolic outcomes (e.g., diabetes, hypertension, and dyslipidemia). However, the underlying cardiometabolic-relevant biological activities of PFAS in humans remain largely unclear. Aim: We evaluated the associations of PFAS exposure with high -throughput proteomics in Hispanic youth. Material and Methods: We included 312 overweight/obese adolescents from the Study of Latino Adolescents at Risk (SOLAR) between 2001 and 2012, along with 137 young adults from the Metabolic and Asthma Incidence Research (Meta -AIR) between 2014 and 2018. Plasma PFAS (i.e., PFOS, PFOA, PFHxS, PFHpS, PFNA) were quantified using liquid -chromatography high -resolution mass spectrometry. Plasma proteins (n = 334) were measured utilizing the proximity extension assay using an Olink Explore Cardiometabolic Panel I. We conducted linear regression with covariate adjustment to identify PFAS-associated proteins. Ingenuity Pathway Analysis, protein -protein interaction network analysis, and protein annotation were used to investigate alterations in biological functions and protein clusters. Results: Results after adjusting for multiple comparisons showed 13 significant PFAS-associated proteins in SOLAR and six in Meta -AIR, sharing similar functions in inflammation, immunity, and oxidative stress. In SOLAR, PFNA demonstrated significant positive associations with the largest number of proteins, including ACP5, CLEC1A, HMOX1, LRP11, MCAM, SPARCL1, and SSC5D. After considering the mixture effect of PFAS, only SSC5D remained significant. In Meta -AIR, PFAS mixtures showed positive associations with GDF15 and IL6. Exploratory analysis showed similar findings. Specifically, pathway analysis in SOLAR showed PFOA- and PFNAassociated activation of immune -related pathways, and PFNA-associated activation of inflammatory response. In Meta -AIR, PFHxS-associated activation of dendric cell maturation was found. Moreover, PFAS was associated with common protein clusters of immunoregulatory interactions and JAK-STAT signaling in both cohorts. Conclusion: PFAS was associated with broad alterations of the proteomic profiles linked to pro -inflammation and immunoregulation. The biological functions of these proteins provide insight into potential molecular mechanisms of PFAS toxicity.
C1 [Chen, Jiawen Carmen; Goodrich, Jesse A.; Liao, Jiawen; Costello, Elizabeth; Hampson, Hailey; Li, Shiwen; Baumert, Brittney O.; Rock, Sarah; Eckel, Sandrah P.; McConnell, Rob; Gilliland, Frank D.; Aung, Max T.; Conti, David V.; Chen, Zhanghua; Chatzi, Lida] Univ Southern Calif, Dept Populat & Publ Hlth Sci, Keck Sch Med, 1845 N Soto St, Los Angeles, CA 90032 USA.
   [Walker, Douglas I.; Valvi, Damaskini] Icahn Sch Med Mt Sinai, Dept Environm Med & Publ Hlth, New York, NY USA.
   [Alderete, Tanya L.] Univ Colorado Boulder, Dept Integrat Physiol, Boulder, CO USA.
   [Jones, Dean P.] Emory Univ, Div Pulm Allergy Crit Care & Sleep Med, Clin Biomarkers Lab, Atlanta, GA USA.
C3 University of Southern California; Icahn School of Medicine at Mount
   Sinai; University of Colorado System; University of Colorado Boulder;
   Emory University
RP Chen, JC (corresponding author), Univ Southern Calif, Dept Populat & Publ Hlth Sci, Keck Sch Med, 1845 N Soto St, Los Angeles, CA 90032 USA.
EM chenjiaw@usc.edu
RI Van Den Berg, David/G-8598-2017; Costello, Elizabeth/GLQ-6132-2022;
   Alderete, Tanya/H-3356-2019; Aung, Max/IAQ-8890-2023; Zhang,
   Jihui/U-7562-2017; Valvi, Dania/ABE-6650-2020; Goodrich,
   Jesse/HPF-7029-2023; Eckel, Sandrah/IAR-2046-2023
OI Chen, Jiawen/0000-0002-6022-9646; Goodrich, Jesse/0000-0001-6615-0472;
   Eckel, Sandrah/0000-0001-6050-7880; Valvi, Dania/0000-0003-4633-229X;
   Costello, Elizabeth/0000-0002-5094-9017; Alderete,
   Tanya/0000-0002-7751-9543
FU National Institute of Environmental Health Science (NIEHS)
   [R01ES029944]; NIEHS [R01ES029944, R01ES030364, R01ES030691,
   P30ES007048, P01CA196569, R21ES029681, P2CES033433-01, R01ES035035,
   P50MD017344, R01ES033688, R21ES035148, P30ES023515, R00ES027870,
   R00ES027853, T32ES013678]; USC
FX The results reported herein correspond to specific aims of grant
   R01ES029944 (Dr. Chatzi, Dr. McConnell, Dr. Conti, Dr. Valvi, and Dr.
   Eckel) from the National Institute of Environmental Health Science
   (NIEHS) . Additional funding from NIEHS supported Dr. Chatzi
   (R01ES030364, R01ES030691, and P30ES007048) , Dr. Conti (R21ES029681,
   R01ES030364, P01CA196569, and P30ES007048) , Dr. McConnell (R21ES029681,
   R01ES030364, P30ES007048, and P2CES033433-01) , Dr. Alderete
   (R01ES035035, P50MD017344) , Dr. Valvi (R01ES033688, R21ES035148, and
   P30ES023515) , Dr. Chen (R00ES027870, R00ES027853) , Dr. Eckel
   (R01ES030364 and P30ES007048) , Dr. Baumert, Ms. Hampson, and Ms.
   Costello (T32ES013678) , and Mrs. Chen (R01ES029944) . Funding from USC
   supported Dr. Li (USC President's Sustainability Initiative Award) .
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NR 103
TC 4
Z9 5
U1 8
U2 25
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0160-4120
EI 1873-6750
J9 ENVIRON INT
JI Environ. Int.
PD APR
PY 2024
VL 186
AR 108601
DI 10.1016/j.envint.2024.108601
EA MAR 2024
PG 13
WC Environmental Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology
GA PR2B7
UT WOS:001215734100001
PM 38537583
OA Green Accepted, gold
DA 2025-06-11
ER

PT J
AU Sabet, N
   Soltani, Z
   Khaksari, M
   Iranpour, M
   Afshar, RM
   Mehdiabadi, FM
   Raji-Amirhasani, A
AF Sabet, Nazanin
   Soltani, Zahra
   Khaksari, Mohammad
   Iranpour, Maryam
   Afshar, Reza Malekpour
   Mehdiabadi, Fatemeh Mousavi
   Raji-Amirhasani, Alireza
TI The effect of two types of diet on apoptosis indexes, lipid profile and
   histopathological outcome in acute kidney injury during exercise
SO BMC NEPHROLOGY
LA English
DT Article
DE Exercise; Acute kidney injury; Apoptosis; Lipid profile; Diet
ID CARDIOMETABOLIC RISK-FACTORS; ACUTE-RENAL-FAILURE; CALORIC RESTRICTION;
   OXIDATIVE STRESS; EXERTIONAL RHABDOMYOLYSIS; CHRONIC NEPHROPATHY;
   INSULIN-RESISTANCE; REPERFUSION INJURY; PHYSICAL-EXERCISE; BRAIN EDEMA
AB Background Exercise and some pre-AKI diets have been shown to improve injury, apoptosis, and lipid profile. In this study, the effect of two different diets along with exercise training on acute kidney injury (AKI) was investigated. Materials and methods Laboratory rats were randomly divided into four groups of control, standard diet + exercise, exercise + calorie restriction (CR) and exercise + time restriction (TR). Each group was divided into two subgroups of AKI and no AKI. The animals received endurance training and diet regimens before AKI. Fasting blood glucose, serum creatinine, Bcl-2-associated X protein (Bax), B-cell lymphoma 2 (Bcl2) and histopathological outcome of renal tissue as well as serum lipid profile of animals were assessed 24 h after AKI. Results The percentage of changes in renal Bcl2 and Bax after AKI in the group with previous exercise was lower than the group without previous exercise (p < 0.01). After induction of AKI, serum lipid profile changed in non-exercised rats (p < 0.001). Also, after injury, fasting blood glucose levels increased in non-exercised rats (p < 0.05). After injury, the start of both CR and TR diets during exercise caused less change in Bcl2 and Bax of non-exercised rats compared to exercised rats (p < 0.001). CR diet along with exercise improved lipid profile, and also CR diet along exercise decreased fasting blood glucose levels (p < 0.001). Also, both the CR and TR diets during exercise caused fewer changes in histopathological outcome after AKI. Conclusion Exercise alone decreased changes in apoptotic and histopathological indexes, fasting blood glucose, as well as lipid profile of rats after AKI. Reduction of apoptosis and improvement of histopathological outcome after AKI appeared more when CR and TR diets were commenced during exercise. The reduction of lipid profile changes was more pronounced in the group that received CR diet during exercise.
C1 [Sabet, Nazanin] Kerman Univ Med Sci, Physiol Res Ctr, Inst Neuropharmacol, Kerman, Iran.
   [Sabet, Nazanin; Soltani, Zahra; Khaksari, Mohammad; Raji-Amirhasani, Alireza] Kerman Univ Med Sci, Afzalipour Fac Med, Dept Physiol & Pharmacol, Kerman, Iran.
   [Soltani, Zahra; Khaksari, Mohammad; Mehdiabadi, Fatemeh Mousavi; Raji-Amirhasani, Alireza] Kerman Univ Med Sci, Fac Med, Endocrinol & Metab Res Ctr, Inst Basic & Clin Physiol Sci, Kerman, Iran.
   [Soltani, Zahra] Kerman Univ Med Sci, Res Ctr Trop & Infect Dis, Kerman, Iran.
   [Iranpour, Maryam; Afshar, Reza Malekpour] Kerman Univ Med Sci, Afzalipour Fac Med, Pathol & Stem Cells Res Ctr, Dept Pathol, Kerman, Iran.
C3 Kerman University of Medical Sciences; Kerman University of Medical
   Sciences; Kerman University of Medical Sciences; Kerman University of
   Medical Sciences; Kerman University of Medical Sciences
RP Soltani, Z (corresponding author), Kerman Univ Med Sci, Afzalipour Fac Med, Dept Physiol & Pharmacol, Kerman, Iran.; Soltani, Z (corresponding author), Kerman Univ Med Sci, Fac Med, Endocrinol & Metab Res Ctr, Inst Basic & Clin Physiol Sci, Kerman, Iran.; Soltani, Z (corresponding author), Kerman Univ Med Sci, Res Ctr Trop & Infect Dis, Kerman, Iran.
EM z.soltani@kmu.ac.ir
RI Afshar, Reza/C-8937-2019; Haddad, Mohammad/AAB-9025-2019; soltani,
   zahra/Q-4137-2016; IRANPOUR, MARYAM/AAH-7467-2019; Raji-Amirhasani,
   Alireza/GLU-7149-2022; Sabet, Nazanin/CAG-6128-2022; musavi mehdiabadi,
   fatemeh/AAD-1646-2020
OI Soltani, Zahra/0000-0002-8423-6189; Mousavi Mehdiabadi,
   Fatemeh/0000-0002-5219-9504
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NR 82
TC 9
Z9 9
U1 0
U2 4
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2369
J9 BMC NEPHROL
JI BMC Nephrol.
PD SEP 19
PY 2022
VL 23
IS 1
AR 315
DI 10.1186/s12882-022-02938-w
PG 15
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 4P5TC
UT WOS:000855455900001
PM 36123655
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Frumuzachi, O
   Mocan, A
   Rohn, S
   Gavrilas, L
AF Frumuzachi, Oleg
   Mocan, Andrei
   Rohn, Sascha
   Gavrilas, Laura
TI Impact of a Chokeberry (Aronia melanocarpa (Michx.) Elliott)
   Supplementation on Cardiometabolic Outcomes: A Critical Systematic
   Review and Meta-Analysis of Randomized Controlled Trials
SO NUTRIENTS
LA English
DT Article
DE chokeberry; Aronia melanocarpa; (poly)phenols; cardiovascular health;
   lipid profile; glycemic control; blood pressure; meta-analysis;
   randomized controlled trial
ID BLOOD-PRESSURE; JUICE CONSUMPTION; OXIDATIVE STRESS; RICH EXTRACT;
   IN-VITRO; POLYPHENOLS; CHOLESTEROL; ANTIOXIDANT; RISK; BIOAVAILABILITY
AB Background/Objectives: Chokeberry (Aronia melanocarpa (Michx.) Elliott) is a (poly)phenol-rich fruit with purported cardiometabolic benefits. However, the evidence from randomized controlled trials (RCTs) remains inconclusive. This systematic review and meta-analysis aimed to assess the effects of chokeberry supplementation on cardiometabolic outcomes, including anthropometric parameters, glycemic control, lipid profile, and blood pressure in adults. Methods: A systematic literature search was conducted in PubMed, Scopus, and Web of Science through January 2025. RCTs investigating chokeberry supplementation (>= 2 weeks) in adults (>= 18 years) with or without cardiometabolic risk factors were included. A random effects model was used to pool effect sizes, expressed as standardized mean differences (SMDs) with 95% confidence intervals (CIs). Heterogeneity was assessed using the I-2 statistic, and risk of bias was evaluated with the Cochrane risk of bias 1 (RoB 1) tool. Trial sequential analysis (TSA) was performed to assess the conclusiveness of the evidence. Certainty of evidence was rated using GRADE. Results: Ten RCTs (n = 666 participants) met the inclusion criteria. Chokeberry supplementation had no significant effects on cardiometabolic outcomes under evaluation. Subgroup analysis suggested that a chokeberry supplementation could reduce total cholesterol and LDL-C in individuals with a baseline total plasma cholesterol <200 mg/dL, and systolic blood pressure with interventions, containing >50 mg/day anthocyanin, while increasing fasting blood glucose in individuals <= 50 years old. Risk of bias was unclear or high in several studies, TSA indicated inconclusive evidence for most outcomes, and the certainty of evidence was rated as very low across all cardiometabolic markers. Conclusions: Chokeberry supplementation did not significantly improve cardiometabolic outcomes in the general adult population. Limited evidence is given for potential lipid-lowering and blood pressure effects in specific subgroups. However, a high risk of bias accompanies these results. More robust RCTs with standardized interventions and dietary assessments are needed.
C1 [Frumuzachi, Oleg; Rohn, Sascha] Tech Univ Berlin, Inst Food Technol & Food Chem, Dept Food Chem & Anal, Gustav Meyer Allee 25, D-13355 Berlin, Germany.
   [Frumuzachi, Oleg; Mocan, Andrei] Iuliu Hatieganu Univ Med & Pharm, Fac Pharm, Dept Pharmaceut Bot, 23 Gheorghe Marinescu St, Cluj Napoca 400337, Romania.
   [Gavrilas, Laura] Iuliu Hatieganu Univ Med & Pharm, Fac Nursing & Hlth Sci, Dept 2, 23 Gheorghe Marinescu St, Cluj Napoca 400337, Romania.
C3 Technical University of Berlin; Iuliu Hatieganu University of Medicine &
   Pharmacy; Iuliu Hatieganu University of Medicine & Pharmacy
RP Rohn, S (corresponding author), Tech Univ Berlin, Inst Food Technol & Food Chem, Dept Food Chem & Anal, Gustav Meyer Allee 25, D-13355 Berlin, Germany.
EM oleg.frumuzachi@elearn.umfcluj.ro; mocan.andrei@umfcluj.ro;
   rohn@tu-berlin.de; laura.gavrilas@umfcluj.ro
RI Mocan, Andrei/AAT-8274-2021; Frumuzachi, Oleg/AES-1559-2022
FU Open Access Publication Fund of Technische Universitat Berlin, Berlin,
   Germany
FX We acknowledge the support from the Open Access Publication Fund of
   Technische Universitat Berlin, Berlin, Germany.
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NR 101
TC 0
Z9 0
U1 2
U2 2
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD APR 28
PY 2025
VL 17
IS 9
AR 1488
DI 10.3390/nu17091488
PG 29
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 2NG4R
UT WOS:001486690400001
PM 40362797
DA 2025-06-11
ER

PT J
AU Abdelsalam, SS
   Zahid, MA
   Raïq, H
   Abunada, HH
   Elsayed, AE
   Parray, A
   Agouni, A
AF Abdelsalam, Shahenda Salah
   Zahid, Muhammad Ammar
   Raiq, Hicham
   Abunada, Hanan H.
   Elsayed, Ahad E.
   Parray, Aijaz
   Agouni, Abdelali
TI The association between plasma levels of Sestrin2 and risk factors of
   cardiovascular diseases in healthy and diabetic adults: A study of Qatar
   Biobank data
SO BIOMOLECULES AND BIOMEDICINE
LA English
DT Article; Early Access
DE Sestrin2; SESN2; cardiovascular disease; CVD; cardiometabolic risk; type
   2 diabetes mellitus; T2DM
AB This study examines the association between serum Sestrin2 (SESN2) levels and cardiovascular disease (CVD) risk factors in healthy and diabetic adults, using data from the Qatar Biobank. A total of 844 participants were included, with 518 in the diabetic cohort and 326 in the healthy cohort. Clinical characteristics, cardiometabolic markers, and Sestrin2 levels were measured, and binomial logistic regression analyses were conducted to assess the associations between Sestrin2 and various health indices. Diabetic patients had significantly lower SESN2 levels compared to healthy controls (5.49 +/- 5.94 vs. 8.25 +/- 7.57 ng/ml, p<0.001). A significant negative correlation was observed between SESN2 and HbA1c (-0.19, p=0.0006), insulin (-0.19, p=0.0006), HOMA-IR (-0.17, p=0.0024), Cpeptide (-0.18, p=0.0012), triglycerides (TG)/HDL ratio (-0.12, p=0.0283), and the pulsatility index (-0.15, p=0.006). In healthy individuals, higher SESN2 levels were associated with lower odds of elevated HbA1c (adjusted odds ratio [AOR] = 0.33, p=0.00), insulin (AOR = 0.23, p=0.00), HOMA-IR (AOR = 0.58, p=0.06), C-peptide (AOR = 0.56, p=0.04), and TG (AOR = 0.37, p=0.03). In contrast, diabetic patients showed a positive correlation between Sestrin2 and insulin (0.15, p=0.0005), HOMA-IR (0.11, p=0.0106), and C-peptide (0.12, p=0.0048). Participants in the highest SESN2 tertile had increased risks for high BMI (AOR = 1.96, p=0.05), high TG (AOR = 1.57, p=0.04), high NTproBNP (AOR = 7.27, p=0.01), and high fibrinogen (AOR = 1.92, p=0.03). These findings suggest that while high SESN2 levels are cardioprotective in healthy individuals, they may indicate higher cellular stress in diabetics. Determining optimal SESN2 levels could help assess CVD risk, particularly in diabetic patients.
C1 [Abdelsalam, Shahenda Salah; Zahid, Muhammad Ammar; Agouni, Abdelali] Qatar Univ, QU Hlth, Coll Pharm, Dept Pharmaceut Sci, Doha, Qatar.
   [Raiq, Hicham; Elsayed, Ahad E.] Qatar Univ, Coll Arts & Sci, Dept Social Sci, Doha, Qatar.
   [Abunada, Hanan H.] Qatar Univ, QU Hlth, Off Vice President Med & Hlth Sci, Doha, Qatar.
   [Parray, Aijaz] Hamad Med Corp, Neurosci Inst, Acad Hlth Syst, Doha, Qatar.
C3 Qatar University; Qatar University; Qatar University; Hamad Medical
   Corporation
RP Agouni, A (corresponding author), Qatar Univ, QU Hlth, Coll Pharm, Dept Pharmaceut Sci, Doha, Qatar.
EM aagouni@qu.edu.qa
RI Agouni, Abdelali/AAP-5298-2020
OI Abunada, Hanan/0000-0003-2186-2518; Zahid, Muhammad
   Ammar/0000-0002-7222-6776; Agouni, Abdelali/0000-0002-8363-1582
FU Qatar National Research Fund (Qatar Research Development and Innovation
   Council); Qatar University; Office of Graduate Studies (Qatar
   University);  [NPRP14S-0406-210150];  [QUST-2-CAS-2024-145]
FX This work was made possible with the support of Qatar Biobank (protocol
   #QF-QBB-RES-ACC-00049-0173) . The study was funded by the Qatar National
   Research Fund (Qatar Research Development and Innovation Council) [grant
   No. NPRP14S-0406-210150] and Qatar University student grant No.
   QUST-2-CAS-2024-145. M.A.Z. and S.S.A. are supported by Ph.D. graduate
   assistantships from the Office of Graduate Studies (Qatar University) .
   The statements made herein are solely the responsibility of the authors.
CR Abdelsalam SS, 2021, MOL MED REP, V24, DOI 10.3892/mmr.2021.12304
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NR 25
TC 1
Z9 1
U1 0
U2 0
PU ASSOC BASIC MEDICAL SCI FEDERATION BOSNIA & HERZEGOVINA SARAJEVO
PI CEKALUSA
PA UNIV SARAJEVO, MEDICAL FAC, CEKALUSA, SARAJEVO 90, BOSNIA & HERCEG
SN 2831-0896
EI 2831-090X
J9 BIOMOL BIOMED
JI Biomol. Biomed.
PD 2024 NOV 29
PY 2024
DI 10.17305/bb.2024.11418
EA NOV 2024
PG 26
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA O1G3X
UT WOS:001368693000001
PM 39636755
OA gold
DA 2025-06-11
ER

PT J
AU Dong, Z
   Gao, X
   Chinchilli, VM
   Sinha, R
   Muscat, J
   Winkels, RM
   Richie, JP 
AF Dong, Zhen
   Gao, Xiang
   Chinchilli, Vernon M.
   Sinha, Raghu
   Muscat, Joshua
   Winkels, Renate M.
   Richie, John P., Jr.
TI Association of sulfur amino acid consumption with cardiometabolic risk
   factors: Cross-sectional findings from NHANES III
SO ECLINICALMEDICINE
LA English
DT Article
DE Dietary sulfur amino acids; Methionine; Cysteine; Cardiometabolic
   diseases; Diabetes; Sulfur amino acids restriction
ID METHIONINE RESTRICTION; LIFE-SPAN; INSULIN-RESISTANCE; OXIDATIVE STRESS;
   DIET; HYPERTENSION; METABOLISM; HEALTH
AB Background: An average adult American consumes sulfur amino acids (SAA) at levels far above the Estimated Average Requirement (EAR) and recent preclinical data suggest that higher levels of SAA intake may be associated with a variety of aging-related chronic diseases. However, there are little data regarding the relationship between SAA intake and chronic disease risk in humans. The aim of this study was to examine the associations between consumption of SAA and risk factors for cardiometabolic diseases.
   Methods: The sample included 11,576 adult participants of the Third National Examination and Nutritional Health Survey (NHANES III) Study (1988-1994). The primary outcome was cardiometabolic disease risk score (composite risk factor based on blood cholesterol, triglycerides, HDL, C-reactive protein (CRP), uric acid, glucose, blood urea nitrogen (BUN), glycated hemoglobin, insulin, and eGFR). Group differences in risk score by quintiles of energy-adjusted total SAA, methionine (Met), and cysteine (Cys) intake were determined by multiple linear regression after adjusting for age, sex, BMI, smoking, alcohol intake, and dietary factors. We further examined for associations between SAA intake and individual risk factors.
   Findings: Mean SAA consumption was > 2.5 -fold higher than the EAR. After multivariable adjustment, higher intake of SAA, Met, and Cys were associated with significant increases in composite cardiometabolic disease risk scores, independent of protein intake, and with several individual risk factors including serum cholesterol, glucose, uric acid, BUN, and insulin and glycated hemoglobin (p < 0.01).
   Interpretation: Overall, our findings suggest that diets lower in SAA (close to the EAR) are associated with reduced risk for cardiometabolic diseases. Low SAA dietary patterns rely on plant-derived protein sources over meat derived foods. Given the high intake of SAA among most adults, our findings may have important public health implications for chronic disease prevention. Funding: This study does not have any funding. (C) 2019 Published by Elsevier Ltd.
C1 [Dong, Zhen; Chinchilli, Vernon M.; Muscat, Joshua; Winkels, Renate M.; Richie, John P., Jr.] Penn State Univ, Penn State Canc Inst, Dept Publ Hlth Sci, Coll Med, 500 Univ Dr,Mail Code CH69, Hershey, PA 17033 USA.
   [Gao, Xiang] Penn State Univ, Dept Nutr Sci, University Pk, PA 16802 USA.
   [Sinha, Raghu] Penn State Univ, Coll Med, Dept Biochem & Mol Biol, Hershey, PA 17033 USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE);
   Pennsylvania State University; Penn State Health; Pennsylvania
   Commonwealth System of Higher Education (PCSHE); Pennsylvania State
   University; Pennsylvania State University - University Park; Penn State
   Behrend; Pennsylvania Commonwealth System of Higher Education (PCSHE);
   Pennsylvania State University; Penn State Health
RP Richie, JP  (corresponding author), Penn State Univ, Penn State Canc Inst, Dept Publ Hlth Sci, Coll Med, 500 Univ Dr,Mail Code CH69, Hershey, PA 17033 USA.
RI Winkels, Renate/AAX-8976-2020; Sinha, Raghu/AAP-6083-2021; Gao,
   Xiang/KFQ-2812-2024
OI Gao, Xiang/0000-0003-2617-6509; Richie, John/0000-0001-8239-2850
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NR 57
TC 38
Z9 41
U1 0
U2 7
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
EI 2589-5370
J9 ECLINICALMEDICINE
JI EClinicalMedicine
PD FEB
PY 2020
VL 19
AR 100248
DI 10.1016/j.eclinm.2019.100248
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA RW0RY
UT WOS:000646233300009
PM 32140669
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Broderick, TL
   Jankowski, M
   Gutkowska, J
AF Broderick, Tom L.
   Jankowski, Marek
   Gutkowska, Jolanta
TI The effects of exercise training and caloric restriction on the cardiac
   oxytocin natriuretic peptide system in the diabetic mouse
SO DIABETES METABOLIC SYNDROME AND OBESITY
LA English
DT Article
DE running; diabetes; GATA4; oxytocin; natriuretic peptides; db/db
ID LIFE-STYLE INTERVENTION; FOOD RESTRICTION; VOLUNTARY EXERCISE;
   GLUCOSE-HOMEOSTASIS; OXIDATIVE STRESS; BODY-WEIGHT; MICE; EXPRESSION;
   INDIVIDUALS; OBESITY
AB Background: Regular exercise training (ET) and caloric restriction (CR) are the frontline strategies in the treatment of type 2 diabetes mellitus with the aim at reducing cardiometabolic risk. ET and CR improve body weight and glycemic control, and experimental studies indicate that these paradigms afford cardioprotection. In this study, the effects of combined ET and CR on the cardioprotective oxytocin (OT)-natriuretic peptide (NP) system were determined in the db/db mouse, a model of type 2 diabetes associated with insulin resistance, hyperglycemia, and obesity.
   Methods: Five-week-old male db/db mice were assigned to the following groups: sedentary, ET, and ET + CR. Nonobese heterozygote littermates served as controls. ET was performed on a treadmill at moderate intensity, and CR was induced by reducing food intake by 30% of that consumed by sedentary db/db mice for a period of 8 weeks.
   Results: After 8 weeks, only ET + CR, but not ET, slightly improved body weight compared to sedentary db/db mice. Regardless of the treatment, db/db mice remained hyperglycemic. Hearts from db/db mice demonstrated reduced expression of genes linked to the cardiac OT-NP system. In fact, compared to control mice, mRNA expression of GATA binding protein 4 (GATA4), OT receptor, OT, brain NP, NP receptor type C, and endothelial nitric oxide synthase (eNOS) was decreased in hearts from sedentary db/db mice. Both ET alone and ET + CR increased the mRNA expression of GATA4 compared to sedentary db/db mice. Only ET combined with CR produced increased eNOS mRNA and protein expression.
   Conclusion: Our data indicate that enhancement of eNOS by combined ET and CR may improve coronary endothelial vasodilator dysfunction in type 2 diabetes but did not prevent the downregulation of cardiac expression in the OT-NP system, possibly resulting from the sustained hyperglycemia and obesity in diabetic mice.
C1 [Broderick, Tom L.] Midwestern Univ, Dept Physiol Lab Diabet & Exercise Metab, 19555 North 59th Ave, Glendale, AZ 85308 USA.
   [Jankowski, Marek; Gutkowska, Jolanta] Ctr Hosp Univ Montreal Hotel Dieu, Dept Med, Lab Cardiovasc Biochem, Montreal, PQ, Canada.
C3 Midwestern University; Midwestern University - Glendale; Universite de
   Montreal
RP Broderick, TL (corresponding author), Midwestern Univ, Dept Physiol Lab Diabet & Exercise Metab, 19555 North 59th Ave, Glendale, AZ 85308 USA.
EM tbrode@midwestern.edu
RI Jankowski, Marek/AAF-7643-2019
FU Diabetes Action Research and Education Foundation; Midwestern University
   Office of Research and Sponsored Programs; Canadian Institute for Health
   Research
FX The study was funded by a grant from the Diabetes Action Research and
   Education Foundation (TLB), the Midwestern University Office of Research
   and Sponsored Programs (TLB), and the Canadian Institute for Health
   Research (JG and MJ).
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NR 57
TC 7
Z9 7
U1 0
U2 18
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-7007
J9 DIABET METAB SYND OB
JI Diabetes Metab. Syndr. Obes.
PY 2017
VL 10
BP 27
EP 36
DI 10.2147/DMSO.S115453
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA EH4MF
UT WOS:000391744600001
PM 28138261
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Charman, SJ
   Brown, E
   Grbovic, M
   Okwose, NC
   Markovic, M
   Ropret, R
   Cassidy, S
   MacGowan, GA
   Jakovljevic, DG
AF Charman, Sarah J.
   Brown, Eleanor
   Grbovic, Miljan
   Okwose, Nduka C.
   Markovic, Milos
   Ropret, Robert
   Cassidy, Sophie
   MacGowan, Guy A.
   Jakovljevic, Djordje G.
TI What are the Physiological Benefits of Increased Daily Number of Steps
   in Middle-Aged Women?
SO AMERICAN JOURNAL OF THE MEDICAL SCIENCES
LA English
DT Article
DE Physical activity; Body composition; Exercise; Tolerance; Cardiac
   function
ID BODY-MASS INDEX; PHYSICAL-ACTIVITY; HEART-FAILURE; CARDIOMETABOLIC RISK;
   CARDIAC POWER; BIOREACTANCE; EXERCISE; GENDER; ASSOCIATIONS; PROGNOSIS
AB Background: Physical activity plays an important role in the prevention of cardio-metabolic diseases. The present study evaluated the effect of habitual physical activity on body composition, peak oxygen consumption, cardiac and metabolic function.
   Methods: This was a retrospective study. Data was collected between February 2014 and November 2015. Thirty-six healthy women (age 50+/-16 years) were stratified according to daily number of steps into low- (<7500 steps/day, n=17) or high-active group (>12500 steps/day, n=19). All participants underwent body composition assessment, oral glucose tolerance test and non-invasive gas-exchange and haemodynamic (bioreactance) measurements at rest and in response to maximal graded cardiopulmonary exercise test.
   Results: The high active group averaged 16280+/-3205 steps/day and the low active group averaged 6285+/-943 steps/day (difference p=0.00). High-active women (vs. low active) demonstrated significantly lower body weight (62.1+/-12.3 vs. 71.2+/- 9.1 kg, p=0.02), body fat (27.2+/-9.1 vs 37.7+/-6.4 %, p=0.00), but increased lean body mass (72.8+/-9.1 vs. 62.3+/-6.4 %, p=0.00). Peak oxygen consumption was significantly higher in high- versus low active women (2.0+/-0.5 vs. 1.5+/-0.2 l/min, p=0.00). There were no significant differences between the groups in fasting- and 2-hour glucose levels (4.9+/-0.6 vs. 4.8+/- 0.5, p=0.45 and 4.8+/-1.3 vs. 5.5+/-1.4 mmol/L, p=0.16) haemodynamic measures of cardiac function including cardiac power output, cardiac output, stroke volume and arterial blood pressure at rest and in response to exercise stress test (p>0.05).
   Conclusions: Increased levels of habitual physical activity improve body composition and peak oxygen consumption but appears to have limited effect cardio-metabolic function in middle-aged women.
C1 [Charman, Sarah J.; Brown, Eleanor; Okwose, Nduka C.; Cassidy, Sophie; Jakovljevic, Djordje G.] Newcastle Univ, Fac Med Sci, Translat & Clin Res Inst, Newcastle Upon Tyne, Tyne & Wear, England.
   [Charman, Sarah J.; Okwose, Nduka C.; Cassidy, Sophie; MacGowan, Guy A.; Jakovljevic, Djordje G.] Newcastle upon Tyne Hosp NHS Fdn Trust, Newcastle Upon Tyne, Tyne & Wear, England.
   [Grbovic, Miljan; Markovic, Milos; Ropret, Robert] Univ Belgrade, Fac Sport & Phys Educ, Belgrade, Serbia.
   [Jakovljevic, Djordje G.] Newcastle Univ, RCUK Ctr Ageing & Vital, Newcastle Upon Tyne, Tyne & Wear, England.
   [Jakovljevic, Djordje G.] Coventry Univ, Fac Hlth & Life Sci, Coventry, W Midlands, England.
C3 Newcastle University - UK; Newcastle Upon Tyne Hospitals NHS Foundation
   Trust; University of Belgrade; Newcastle University - UK; Coventry
   University
RP Charman, SJ (corresponding author), Newcastle Univ, Fac Med Sci, Translat & Clin Res Inst, Newcastle Upon Tyne, Tyne & Wear, England.
EM sarah.charman@newcastle.ac.uk
RI Markovic, Milos/HOC-1823-2023; Okwose, Nduka/AAA-7497-2020
OI MacGowan, Guy/0000-0002-2685-4165; Markovic, Milos/0000-0001-9150-0390;
   Okwose, Nduka/0000-0003-0145-2538; Charman, Sarah/0000-0002-3029-7672;
   Jakovljevic, Professor Djordje/0000-0003-2686-6542
FU NIHR Newcastle Biomedical Research Centre in Ageing and Age-Related
   Disease
FX Funding was obtained by the NIHR Newcastle Biomedical Research Centre in
   Ageing and Age-Related Disease.
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NR 38
TC 0
Z9 0
U1 0
U2 2
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0002-9629
EI 1538-2990
J9 AM J MED SCI
JI Am. J. Med. Sci.
PD NOV
PY 2020
VL 360
IS 5
BP 591
EP 595
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA OH6MH
UT WOS:000582705300020
PM 32838955
DA 2025-06-11
ER

PT J
AU Cheng, FF
   Luk, AO
   Tam, CHT
   Fan, BQ
   Wu, HJ
   Yang, AM
   Lau, ESH
   Ng, ACW
   Lim, CKP
   Lee, HM
   Chow, E
   Kong, AP
   Keech, AC
   Joglekar, MV
   So, WY
   Jenkins, AJ
   Chan, JCN
   Hardikar, AA
   Ma, RCW
AF Cheng, Feifei
   Luk, Andrea O.
   Tam, Claudia H. T.
   Fan, Baoqi
   Wu, Hongjiang
   Yang, Aimin
   Lau, Eric S. H.
   Ng, Alex C. W.
   Lim, Cadmon K. P.
   Lee, Heung Man
   Chow, Elaine
   Kong, Alice P.
   Keech, Anthony C.
   Joglekar, Mugdha V.
   So, Wing Yee
   Jenkins, Alicia J.
   Chan, Juliana C. N.
   Hardikar, Anandwardhan A.
   Ma, Ronald C. W.
TI Shortened Relative Leukocyte Telomere Length Is Associated With
   Prevalent and Incident Cardiovascular Complications in Type 2 Diabetes:
   Analysis From the Hong Kong Diabetes Register
SO DIABETES CARE
LA English
DT Article
ID CORONARY-HEART-DISEASE; UKPDS RISK ENGINE; OXIDATIVE STRESS; CHINESE
   PATIENTS; BIOLOGICAL AGE; CELLS; RECEPTORS; TARGETS; MODEL; MEN
AB OBJECTIVE Several studies support potential links between relative leukocyte telomere length (rLTL), a biomarker of biological aging, and type 2 diabetes. This study investigates relationships between rLTL and incident cardiovascular disease (CVD) in patients with type 2 diabetes. RESEARCH DESIGN AND METHODS Consecutive Chinese patients with type 2 diabetes (N= 5,349) from the Hong Kong Diabetes Register for whom DNA obtained at baseline was stored and follow-up data were available were studied. rLTL was measured by using quantitative PCR. CVD was diagnosed on the basis of ICD-9 code. RESULTS Mean follow-up was 13.4 years (SD 5.5 years). rLTL was correlated inversely with age, diabetes duration, blood pressure, HbA(1c), and urine albumin-to-creatinine ratio (ACR), and positively with estimated glomerular filtration rate (eGFR) (allP< 0.001). Subjects with CVD at baseline had a shorter rLTL (4.3 +/- 1.2 Delta Delta Ct) than did subjects without CVD (4.6 +/- 1.2 Delta Delta Ct) (P< 0.001). Of the 4,541 CVD-free subjects at baseline, the 1,140 who developed CVD during follow-up had a shorter rLTL (4.3 +/- 1.2 Delta Delta Ct) than those who remained CVD-free after adjusting for age, sex, smoking, and albuminuria status (4.7 +/- 1.2 Delta Delta Ct) (P< 0.001). In Cox regression models, shorter rLTL was associated with higher risk of incident CVD (for each unit decrease, hazard ratio 1.252 [95% CI 1.195-1.311],P< 0.001), which remained significant after adjusting for age, sex, BMI, systolic blood pressure, LDL cholesterol, HbA(1c), eGFR, and ACR (hazard ratio 1.141 [95% CI 1.084-1.200],P< 0.001). CONCLUSIONS rLTL is significantly shorter in patients with type 2 diabetes and CVD, is associated with cardiometabolic risk factors, and is independently associated with incident CVD. Telomere length may be a useful biomarker for CVD risk in patients with type 2 diabetes.
C1 [Cheng, Feifei; Luk, Andrea O.; Tam, Claudia H. T.; Fan, Baoqi; Wu, Hongjiang; Yang, Aimin; Lau, Eric S. H.; Ng, Alex C. W.; Lim, Cadmon K. P.; Lee, Heung Man; Chow, Elaine; Kong, Alice P.; So, Wing Yee; Chan, Juliana C. N.; Ma, Ronald C. W.] Chinese Univ Hong Kong, Prince Wales Hosp, Dept Med & Therapeut, Hong Kong, Peoples R China.
   [Luk, Andrea O.; Tam, Claudia H. T.; Fan, Baoqi; Yang, Aimin; Chow, Elaine; Kong, Alice P.; So, Wing Yee; Chan, Juliana C. N.; Ma, Ronald C. W.] Chinese Univ Hong Kong, Hong Kong Inst Diabet & Obes, Prince Wales Hosp, Hong Kong, Peoples R China.
   [Luk, Andrea O.; Tam, Claudia H. T.; Lim, Cadmon K. P.; Lee, Heung Man; Kong, Alice P.; Chan, Juliana C. N.; Ma, Ronald C. W.] Chinese Univ Hong Kong, Li Ka Shing Inst Hlth Sci, Prince Wales Hosp, Hong Kong, Peoples R China.
   [Lau, Eric S. H.] Asia Diabet Fdn, Shatin, Hong Kong, Peoples R China.
   [Keech, Anthony C.; Joglekar, Mugdha V.; Jenkins, Alicia J.; Hardikar, Anandwardhan A.; Ma, Ronald C. W.] Univ Sydney, Fac Med & Hlth, NHMRC Clin Trial Ctr, Sydney, NSW, Australia.
   [Chan, Juliana C. N.; Ma, Ronald C. W.] Chinese Univ Hong Kong Shanghai Jiao Tong Univ Jo, Prince Wales Hosp, Hong Kong, Peoples R China.
C3 Chinese University of Hong Kong; Prince of Wales Hospital; Chinese
   University of Hong Kong; Prince of Wales Hospital; Chinese University of
   Hong Kong; Prince of Wales Hospital; University of Sydney; Chinese
   University of Hong Kong; Prince of Wales Hospital
RP Ma, RCW (corresponding author), Chinese Univ Hong Kong, Prince Wales Hosp, Dept Med & Therapeut, Hong Kong, Peoples R China.; Ma, RCW (corresponding author), Chinese Univ Hong Kong, Hong Kong Inst Diabet & Obes, Prince Wales Hosp, Hong Kong, Peoples R China.; Ma, RCW (corresponding author), Chinese Univ Hong Kong, Li Ka Shing Inst Hlth Sci, Prince Wales Hosp, Hong Kong, Peoples R China.; Ma, RCW (corresponding author), Univ Sydney, Fac Med & Hlth, NHMRC Clin Trial Ctr, Sydney, NSW, Australia.; Ma, RCW (corresponding author), Chinese Univ Hong Kong Shanghai Jiao Tong Univ Jo, Prince Wales Hosp, Hong Kong, Peoples R China.
EM rcwma@cuhk.edu.hk
RI Jenkins, Alicia/N-2482-2015; Yang, Aimin/D-8344-2015; Joglekar,
   Mugdha/AFP-0659-2022; Lau, Eric S.H./AGZ-2920-2022; Kong,
   Alice/P-3703-2015; Luk, Andrea/B-5766-2016; Hardikar,
   Anandwardhan/ACF-7730-2022; Wu, Hongjiang/AAJ-8907-2020; Chan,
   Juliana/B-7918-2016; Chow, Elaine/HJB-2197-2022; Ma, Ronald/C-2788-2009
OI Chan, Juliana/0000-0003-1325-1194; Wu, Hongjiang/0000-0003-2193-1114;
   Jenkins, Alicia/0000-0003-0583-3717; Kong, Alice/0000-0001-8927-6764;
   Chow, Elaine/0000-0002-4147-3387; Ma, Ronald/0000-0002-1227-803X;
   Joglekar, Mugdha/0000-0001-5346-2266; Lau, Eric S.
   H./0000-0003-1581-5643
FU Research Grants Council [T12-402/13N, R4012-18]; Chinese University of
   Hong Kong Vice-Chancellor One-off Discretionary Fund; Chinese University
   of Hong Kong-Shanghai Jiao Tong University Joint Research Fund; Chinese
   University of Hong Kong Global Scholarship Programme for Research
   Excellence; Internationalization Faculty Mobility Schemes (Outbound
   Research Mobility Scheme) from the Office of Academic Links, Chinese
   University of Hong Kong; JDRF in the U.S.; JDRF in the Australia
FX This study was supported by the Research Grants Council Theme-based
   Research Scheme (T12-402/13N) and Research Impact Fund (R4012-18), the
   Chinese University of Hong Kong Vice-Chancellor One-off Discretionary
   Fund, and the Chinese University of Hong Kong-Shanghai Jiao Tong
   University Joint Research Fund. F.C., A.A.H., and R.C.W.M. have received
   support from the Chinese University of Hong Kong Global Scholarship
   Programme for Research Excellence. R.C.W.M. has received support from
   the Internationalization Faculty Mobility Schemes (Outbound Research
   Mobility Scheme) from the Office of Academic Links, Chinese University
   of Hong Kong. M.V.J. and A.A.H. have received fellowships from JDRF in
   the U.S. and Australia, respectively.
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NR 39
TC 39
Z9 39
U1 1
U2 19
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0149-5992
EI 1935-5548
J9 DIABETES CARE
JI Diabetes Care
PD SEP
PY 2020
VL 43
IS 9
BP 2257
EP 2265
DI 10.2337/dc20-0028
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA NB9CP
UT WOS:000560813100043
PM 32661111
DA 2025-06-11
ER

PT J
AU Lee, J
   Costa-Dookhan, K
   Panganiban, K
   MacKenzie, N
   Treen, QC
   Chintoh, A
   Remington, G
   Mueller, DJ
   Sockalingam, S
   Gerretsen, P
   Sanches, M
   Karnovsky, A
   Stringer, KA
   Ellingrod, VL
   Tso, IF
   Taylor, SF
   Agarwal, SM
   Hahn, MK
   Ward, KM
AF Lee, Jiwon
   Costa-Dookhan, Kenya
   Panganiban, Kristoffer
   MacKenzie, Nicole
   Treen, Quinn Casuccio
   Chintoh, Araba
   Remington, Gary
   Mueller, Daniel J. J.
   Sockalingam, Sanjeev
   Gerretsen, Philip
   Sanches, Marcos
   Karnovsky, Alla
   Stringer, Kathleen A.
   Ellingrod, Vicki L. L.
   Tso, Ivy F. F.
   Taylor, Stephan F. F.
   Agarwal, Sri Mahavir
   Hahn, Margaret K. K.
   Ward, Kristen M. M.
TI Metabolomic signatures associated with weight gain and psychosis
   spectrum diagnoses: A pilot study
SO FRONTIERS IN PSYCHIATRY
LA English
DT Article
DE metabolomics; fatty acids; antipsychotics; schizophrenia; weight gain;
   psychosis
ID PLASMA PALMITOLEIC ACID; INFLAMMATORY RESPONSE; OXIDATIVE STRESS;
   LDL-CHOLESTEROL; NAIVE PATIENTS; 1ST EPISODE; FATTY-ACIDS;
   SCHIZOPHRENIA; METAANALYSIS; INSULIN
AB Psychosis spectrum disorders (PSDs), as well as other severe mental illnesses where psychotic features may be present, like bipolar disorder, are associated with intrinsic metabolic abnormalities. Antipsychotics (APs), the cornerstone of treatment for PSDs, incur additional metabolic adversities including weight gain. Currently, major gaps exist in understanding psychosis illness biomarkers, as well as risk factors and mechanisms for AP-induced weight gain. Metabolomic profiles may identify biomarkers and provide insight into the mechanistic underpinnings of PSDs and antipsychotic-induced weight gain. In this 12-week prospective naturalistic study, we compared serum metabolomic profiles of 25 cases within approximately 1 week of starting an AP to 6 healthy controls at baseline to examine biomarkers of intrinsic metabolic dysfunction in PSDs. In 17 of the case participants with baseline and week 12 samples, we then examined changes in metabolomic profiles over 12 weeks of AP treatment to identify metabolites that may associate with AP-induced weight gain. In the cohort with pre-post data (n = 17), we also compared baseline metabolomes of participants who gained >= 5% baseline body weight to those who gained <5% to identify potential biomarkers of antipsychotic-induced weight gain. Minimally AP-exposed cases were distinguished from controls by six fatty acids when compared at baseline, namely reduced levels of palmitoleic acid, lauric acid, and heneicosylic acid, as well as elevated levels of behenic acid, arachidonic acid, and myristoleic acid (FDR < 0.05). Baseline levels of the fatty acid adrenic acid was increased in 11 individuals who experienced a clinically significant body weight gain (>= 5%) following 12 weeks of AP exposure as compared to those who did not (FDR = 0.0408). Fatty acids may represent illness biomarkers of PSDs and early predictors of AP-induced weight gain. The findings may hold important clinical implications for early identification of individuals who could benefit from prevention strategies to reduce future cardiometabolic risk, and may lead to novel, targeted treatments to counteract metabolic dysfunction in PSDs.
C1 [Lee, Jiwon; Costa-Dookhan, Kenya; Panganiban, Kristoffer; MacKenzie, Nicole; Treen, Quinn Casuccio; Chintoh, Araba; Remington, Gary; Agarwal, Sri Mahavir; Hahn, Margaret K. K.] Ctr Addict & Mental Hlth, Schizophrenia Div, Toronto, ON, Canada.
   [Lee, Jiwon; Costa-Dookhan, Kenya; Panganiban, Kristoffer; Chintoh, Araba; Remington, Gary; Mueller, Daniel J. J.; Sockalingam, Sanjeev; Gerretsen, Philip; Agarwal, Sri Mahavir; Hahn, Margaret K. K.] Univ Toronto, Inst Med Sci, Toronto, ON, Canada.
   [Chintoh, Araba; Remington, Gary; Mueller, Daniel J. J.; Sockalingam, Sanjeev; Gerretsen, Philip; Agarwal, Sri Mahavir; Hahn, Margaret K. K.] Univ Toronto, Dept Psychiat, Toronto, ON, Canada.
   [Mueller, Daniel J. J.] Univ Toronto, Dept Pharmacol & Toxicol, Toronto, ON, Canada.
   [Mueller, Daniel J. J.] Ctr Addict & Mental Hlth, Pharmacogenet Res Clin, Toronto, ON, Canada.
   [Sockalingam, Sanjeev] Ctr Addict & Mental Hlth, Educ, Toronto, ON, Canada.
   [Gerretsen, Philip] Ctr Addict & Mental Hlth, Geriatr Mental Hlth Serv, Toronto, ON, Canada.
   [Sanches, Marcos] Ctr Addict & Mental Hlth, Biostat, Toronto, ON, Canada.
   [Karnovsky, Alla; Ward, Kristen M. M.] Univ Michigan, Dept Computat Med & Bioinformat, Med Sch, Ann Arbor, MI 48109 USA.
   [Stringer, Kathleen A.; Ellingrod, Vicki L. L.] Univ Michigan, Dept Clin Pharm, Coll Pharm, Ann Arbor, MI USA.
   [Ellingrod, Vicki L. L.; Tso, Ivy F. F.; Taylor, Stephan F. F.] Univ Michigan, Dept Psychiat, Med Sch, Ann Arbor, MI USA.
   [Tso, Ivy F. F.] Ohio State Univ, Dept Psychiat & Behav Hlth, Columbus, OH USA.
   [Agarwal, Sri Mahavir; Hahn, Margaret K. K.] Univ Toronto, Banting & Best Diabet Ctr, Toronto, ON, Canada.
C3 University of Toronto; Centre for Addiction & Mental Health - Canada;
   University of Toronto; University of Toronto; University of Toronto;
   University of Toronto; Centre for Addiction & Mental Health - Canada;
   University of Toronto; Centre for Addiction & Mental Health - Canada;
   University of Toronto; Centre for Addiction & Mental Health - Canada;
   University of Toronto; Centre for Addiction & Mental Health - Canada;
   University of Michigan System; University of Michigan; University of
   Michigan System; University of Michigan; University of Michigan System;
   University of Michigan; University System of Ohio; Ohio State
   University; University of Toronto
RP Ward, KM (corresponding author), Univ Michigan, Dept Computat Med & Bioinformat, Med Sch, Ann Arbor, MI 48109 USA.
EM kmwiese@umich.edu
RI Sockalingam, Sanjeev/I-7212-2016; Agarwal, Mahavir/ITV-3244-2023;
   Taylor, Stephan/A-1211-2007; Müller, Daniel/A-5967-2010; Sanches,
   Marcos/ADC-0738-2022; Hahn, Margaret/F-5034-2014; Mueller,
   Daniel/L-4159-2016
OI Taylor, Stephan/0000-0001-8777-4292; Hahn, Margaret/0000-0001-8884-9946;
   MacKenzie, Nicole/0000-0002-7097-5706; Mueller,
   Daniel/0000-0003-4978-4400
FU University of Michigan's Regional Comprehensive Metabolomics Resource
   Core; National Institute of Health (NIH), National Center for Advancing
   Translational Sciences (NCATS); NIH award from the National Institute of
   General Medical Sciences (NIGMS); Hilda and William Courtney Clayton
   Pediatric Research Fund; LG Rao/Industrial Partners Graduate Student
   Award from the University of Toronto; Meighen Family Chair in Psychosis
   Prevention [DK097153]; Cardy Schizophrenia Research Chair [2UL1TR000433,
   KL2TR002241]; Danish Diabetes Academy Professorship [R35GM136312]; Steno
   Diabetes Center Fellowship; U of T Academic Scholar Award; Canadian
   Institutes of Health Research (CIHR); Banting and Best Diabetes Center;
   PSI Foundation; National Institute of Mental Health; University of
   Toronto; HLS Therapeutics, Inc.; Boehringer-Ingelheim;  [R01MH122491]
FX Funding for this work was supported in part by grants from the following
   centers (no funding agencies were involved in study design, collection,
   analysis and interpretation of data, writing of the manuscript, or
   decision to submit for publication): the University of Michigan's
   Regional Comprehensive Metabolomics Resource Core (grant DK097153). KW
   was supported by the National Institute of Health (NIH), National Center
   for Advancing Translational Sciences (NCATS), Award Nos. 2UL1TR000433
   and KL2TR002241. KS effort was supported in part by an NIH award from
   the National Institute of General Medical Sciences (NIGMS; R35GM136312).
   The content is solely the responsibility of the authors and does not
   necessarily represent the official views of the NIH. JL is supported by
   the Hilda and William Courtney Clayton Pediatric Research Fund and LG
   Rao/Industrial Partners Graduate Student Award from the University of
   Toronto, and Meighen Family Chair in Psychosis Prevention. MH holds the
   Meighen Family Chair in Psychosis Prevention, the Cardy Schizophrenia
   Research Chair, a Danish Diabetes Academy Professorship, a Steno
   Diabetes Center Fellowship, and a U of T Academic Scholar Award, and is
   funded by operating grants from the Canadian Institutes of Health
   Research (CIHR), the Banting and Best Diabetes Center, and the PSI
   Foundation. IT was supported by National Institute of Mental Health
   (R01MH122491). GR has received research support from the Canadian
   Institutes of Health Research (CIHR), University of Toronto, and HLS
   Therapeutics, Inc. ST has received contracted research funding from
   Boehringer-Ingelheim, not relevant to the content of this report.
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NR 53
TC 4
Z9 4
U1 2
U2 3
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-0640
J9 FRONT PSYCHIATRY
JI Front. Psychiatry
PD APR 24
PY 2023
VL 14
AR 1169787
DI 10.3389/fpsyt.2023.1169787
PG 9
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA F5JF5
UT WOS:000982701000001
PM 37168086
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Caceres, BA
   Sharma, Y
   Levine, A
   Wall, MM
   Hughes, TL
AF Caceres, Billy A.
   Sharma, Yashika
   Levine, Alina
   Wall, Melanie M.
   Hughes, Tonda L.
TI Investigating the Associations of Sexual Minority Stressors and Incident
   Hypertension in a Community Sample of Sexual Minority Adults
SO ANNALS OF BEHAVIORAL MEDICINE
LA English
DT Article
DE Sexual and gender minorities; Hypertension; Social discrimination;
   Cardiovascular disease
ID MODIFIABLE RISK-FACTORS; SUBSTANCE USE DISORDERS;
   CARDIOVASCULAR-DISEASE; BLOOD-PRESSURE; RACIAL-DISCRIMINATION;
   MENTAL-HEALTH; CARDIOMETABOLIC RISK; UNITED-STATES; STIGMA
   CONSCIOUSNESS; POPULATION HEALTH
AB Lay Summary High blood pressure (HBP) is a major public health concern in the USA. Sexual minority adults (such as gay/lesbian or bisexual) are at greater risk of HBP than heterosexual adults. However, the reasons for this difference have not been studied. Sexual minority stressors are unique stressors specific to sexual minority individuals. Multiple studies have shown that sexual minority stressors, such as internalized homophobia (defined as someone's internalization of negative societal values towards sexual minority individuals), stigma consciousness (defined as the extent that someone expects to be stereotyped), and experiences of discrimination due to sexual identity, are associated with poor health outcomes. Yet, the relationship between these stressors and HBP has not been studied in this population. In our study, we examined the associations between sexual minority stressors and newly diagnosed HBP among sexual minority adults. Those who reported more internalized homophobia had a higher likelihood of developing HBP within 7 years. There were no significant associations between other sexual minority stressors and HBP. We also found no differences in the associations of sexual minority stressors and HBP by race/ethnicity or sexual identity. Findings highlight the importance of educating healthcare professionals about risk factors for hypertension in sexual minority adults.
   Background Sexual minority adults are at higher risk of hypertension than their heterosexual counterparts. Sexual minority stressors (i.e., unique stressors attributed to sexual minority identity) are associated with a variety of poor mental and physical health outcomes. Previous research has not tested associations between sexual minority stressors and incident hypertension among sexual minority adults. Purpose To examine the associations between sexual minority stressors and incident hypertension among sexual minority adults assigned female sex at birth. Methods Using data from a longitudinal study, we examined associations between three sexual minority stressors and self-reported hypertension. We ran multiple logistic regression models to estimate the associations between sexual minority stressors and hypertension. We conducted exploratory analyses to determine whether these associations differed by race/ethnicity and sexual identity (e.g., lesbian/gay vs. bisexual). Results The sample included 380 adults, mean age 38.4 (+/- 12.81) years. Approximately 54.5% were people of color and 93.9% were female-identified. Mean follow-up was 7.0 (+/- 0.6) years; during which 12.4% were diagnosed with hypertension. We found that a 1-standard deviation increase in internalized homophobia was associated with higher odds of developing hypertension (AOR 1.48, 95% Cl: 1.06-2.07). Stigma consciousness (AOR 0.85, 95% CI: 0.56-1.26) and experiences of discrimination (AOR 1.07, 95% CI: 0.72-1.52) were not associated with hypertension. The associations of sexual minority stressors with hypertension did not differ by race/ethnicity or sexual identity. Conclusions This is the first study to examine the associations between sexual minority stressors and incident hypertension in sexual minority adults. Implications for future studies are highlighted.
C1 [Caceres, Billy A.; Sharma, Yashika; Hughes, Tonda L.] Columbia Univ, Sch Nursing, 560 West 168th St Room 603, New York, NY 10032 USA.
   [Caceres, Billy A.; Sharma, Yashika; Hughes, Tonda L.] Columbia Univ, Sch Nursing, Ctr Sexual & Gender Minor Hlth Res, 560 West 168th St, New York, NY 10032 USA.
   [Levine, Alina; Wall, Melanie M.] Columbia Mailman Sch Publ Hlth, Dept Biostat, 722 West 168th St, New York, NY 10032 USA.
C3 Columbia University; Columbia University
RP Caceres, BA (corresponding author), Columbia Univ, Sch Nursing, 560 West 168th St Room 603, New York, NY 10032 USA.; Caceres, BA (corresponding author), Columbia Univ, Sch Nursing, Ctr Sexual & Gender Minor Hlth Res, 560 West 168th St, New York, NY 10032 USA.
EM bac2134@cumc.columbia.edu
OI Caceres, Billy/0000-0001-6865-5546
FU National Heart, Lung, and Blood Institute [K01HL146965]; National
   Institute on Alcohol Abuse and Alcoholism [R01AA013328-15]; American
   Heart Association [899585]; American Heart Association (AHA) [899585]
   Funding Source: American Heart Association (AHA)
FX Dr. Caceres was supported by National Heart, Lung, and Blood Institute
   (K01HL146965). Dr. Hughes was supported by National Institute on Alcohol
   Abuse and Alcoholism (R01AA013328-15). Yashika Sharma was supported by a
   predoctoral fellowship from the American Heart Association (Grant number
   899585).
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NR 96
TC 5
Z9 6
U1 0
U2 6
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0883-6612
EI 1532-4796
J9 ANN BEHAV MED
JI Ann. Behav. Med.
PD NOV 16
PY 2023
VL 57
IS 12
BP 1004
EP 1013
DI 10.1093/abm/kaac073
EA JUN 2023
PG 10
WC Psychology, Multidisciplinary
WE Social Science Citation Index (SSCI)
SC Psychology
GA Y0VJ4
UT WOS:001004087100001
PM 37306778
OA Green Published
DA 2025-06-11
ER

PT J
AU Sone, T
   Nakaya, N
   Sugawara, Y
   Nakaya, K
   Hoshi, M
   Tabuchi, T
   Hozawa, A
AF Sone, Toshimasa
   Nakaya, Naoki
   Sugawara, Yumi
   Nakaya, Kumi
   Hoshi, Masayuki
   Tabuchi, Takahiro
   Hozawa, Atsushi
TI Effect of Social Support on Caregiver's Functional Disability Due to
   Spouse's Functional Disability
SO JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
LA English
DT Article
DE Social support; functional disability; caregivers
ID CARDIOMETABOLIC RISK-FACTORS; LONGITUDINAL FINDINGS; MARRIED-COUPLES;
   PARTNERS; JAPANESE; SIMILARITIES; ASSOCIATIONS; TRAJECTORIES; STRESS;
   BURDEN
AB Objectives: To examine the effect of social support on the risk of caregiver's functional disability due to spouse's functional disability. Design: Longitudinal study. Setting and Participants: In this cohort study using the Ohsaki Cohort 2006 Study data, the baseline survey was conducted from December 1, 2006, to December 15, 2006, and included 7598 older adults, including 3799 couples, >= 65 years of age. Methods: The incidence of spouse's functional disability was defined as certification for the Long-term Care Insurance, which uses a nationally uniform standard of functional disability. The primary outcome was the incidence of the caregiver's functional disability, and the follow-up period was between December 16, 2006, and November 30, 2019. Five social support questionnaires were used to assess the degree of emotional and instrumental social support available to each participant. The Cox proportional hazards model was used to evaluate the incidence of functional disability among caregivers after the occurrence of spouses' functional disability. Subgroup analyses were also conducted according to the status of emotional and instrumental social support. Results: The caregiver's functional disability increased significantly among those whose spouses had functional disability compared with those whose spouses had no disability [multivariate hazard ratio (HR), 1.86]. Emotional and instrumental social support showed significant positive interactions on this association (emotional and instrumental support: P for interaction < .01 and < .01, respectively), and the risk of caregiver's disability was higher among those without social support than among those with social support (with emotional support: HR, 1.84; without emotional support: HR, 2.51; with instrumental support: HR, 1.85; without instrumental support: HR, 2.31). Conclusions and Implications: Social support may help to alleviate the increased risk for caregiver's functional disability due to the spouse's functional disability. (c) 2024 The Author(s). Published by Elsevier Inc. on behalf of Post-Acute and Long-Term Care Medical Association.
C1 [Sone, Toshimasa] Fukushima Med Univ, Sch Hlth Sci, Dept Occupat Therapy, 10-6 Sakae Machi, Fukushima, Fukushima 9608516, Japan.
   [Sone, Toshimasa; Sugawara, Yumi; Nakaya, Kumi; Hoshi, Masayuki; Tabuchi, Takahiro; Hozawa, Atsushi] Tohoku Univ, Grad Sch Med, Dept Hlth Informat & Publ Hlth, Div Epidemiol,Sch Publ Hlth, Sendai, Japan.
   [Nakaya, Naoki] Tohoku Univ, Dept Prevent Med & Epidemiol, Div Hlth Behav Epidemiol, Tohoku Med Megabank Org, Sendai, Japan.
   [Hoshi, Masayuki] Fukushima Med Univ, Sch Hlth Sci, Dept Phys Therapy, Fukushima, Japan.
C3 Fukushima Medical University; Tohoku University; Tohoku University;
   Fukushima Medical University
RP Sone, T (corresponding author), Fukushima Med Univ, Sch Hlth Sci, Dept Occupat Therapy, 10-6 Sakae Machi, Fukushima, Fukushima 9608516, Japan.
EM tsone@fmu.ac.jp
RI Tabuchi, Takahiro/KFQ-0737-2024
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NR 42
TC 0
Z9 0
U1 4
U2 5
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1525-8610
EI 1538-9375
J9 J AM MED DIR ASSOC
JI J. Am. Med. Dir. Assoc.
PD JAN
PY 2025
VL 26
IS 1
AR 105324
DI 10.1016/j.jamda.2024.105324
EA NOV 2024
PG 7
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA M6A5M
UT WOS:001358343800001
PM 39461363
OA hybrid
DA 2025-06-11
ER

PT J
AU Li, TJ
   Chen, LL
   Liang, X
   Li, XY
   Li, YQ
   Huang, YT
   Wang, Y
AF Li, Tanjian
   Chen, Lulu
   Liang, Xin
   Li, Xinya
   Li, Yaqin
   Huang, Yuting
   Wang, Yu
TI Inverse association between atherogenic index of plasma and testosterone
   in US adult males: A large cross-sectional study from the NAHNES
   2011-2016
SO FRONTIERS IN PHYSIOLOGY
LA English
DT Article
DE NHANES; atherogenic index of plasma; testosterone; testosterone
   deficiency; male
ID HORMONE-BINDING GLOBULIN; METABOLIC SYNDROME; OXIDATIVE STRESS;
   SEX-HORMONES; DEFICIENCY; CHOLESTEROL; OBESITY; MEN
AB Background and objectives: The atherogenic index of plasma (AIP), defined as log10 (triglycerides/high-density lipoprotein cholesterol), serves as a biomarker for atherosclerosis and cardiovascular disease (CVD). It is also associated with conditions such as type 2 diabetes, insulin resistance, depression, and both cardiovascular and overall mortality. Serum lipids have been proven to influence serum testosterone levels, and AIP is a significant marker of lipid levels. We hypothesize that AIP may have a specific relationship with testosterone. This article aims to evaluate the correlation between AIP and total testosterone (TT), as well as testosterone deficiency (TD), among the U.S. population. Methods: Data were collected from the National Health and Nutrition Examination Survey (NHANES) database between 2011 and 2016. This study was categorized into four groups based on the quartiles of AIP. Weighted multivariate linear regression and logistic regression were utilized to evaluate the relationships between AIP and TT, TD. Restricted cubic spline (RCS) was used to investigate the non-linear association between AIP and TT and TD. The subgroup analysis method was employed to investigate the relationships between AIP and TT, TD across various stratifications. Ultimately, the sensitivity study involved a comparison of weighted and unweighted data analyses to ascertain the stability of the conclusions. Results: A total of 2,572 participants were included in the final study. After adjusting for all confounding factors, multivariate linear regression showed that AIP was independently negatively associated with TT (beta = -93.42, 95%CI: -123.66, -63.18, P < 0.001), and multivariate logistic regression showed that AIP level was associated with higher risk of TD (OR = 3.45, 95%CI: 2.09, 5.69, P < 0.001). In the quartile of AIP, TT levels decreased the most (beta = -74.81, 95%CI: -105.27, -44.35, p < 0.001) and the risk of TD was highest (OR = 2.89, 95%CI: 1.70, 4.93, p < 0.001). In addition, stratified analyses showed similar results in all subgroups except those with diabetes (P for interaction >0.05 for all comparisons). The final sensitivity analysis revealed that elevated AIP were also associated with decreased TT (beta = -101.74, 95%CI: -123.18, -80.3, P < 0.001) and increased incidence of TD (OR = 3.01, 95%CI: 2.17, 4.17, P < 0.001) on unweighted data. Conclusion: Increased levels of AIP correlate with decreased TT levels and a higher prevalence of TD. Additional research is necessary to investigate the underlying mechanisms connecting them.
C1 [Li, Tanjian; Liang, Xin; Li, Xinya; Li, Yaqin; Huang, Yuting] Jinan Univ, Sch Nursing, Guangzhou, Guangdong, Peoples R China.
   [Chen, Lulu] Shenzhen Childrens Hosiptal, Dept Stomatol, Shenzhen, Gaundong, Peoples R China.
   [Wang, Yu] Jinan Univ, Affiliated Hosp 1, Jinan Community Hlth Serv Ctr, Guangzhou, Guangdong, Peoples R China.
C3 Jinan University; Jinan University
RP Wang, Y (corresponding author), Jinan Univ, Affiliated Hosp 1, Jinan Community Hlth Serv Ctr, Guangzhou, Guangdong, Peoples R China.
EM hulibuwangyu@126.com
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NR 54
TC 0
Z9 0
U1 5
U2 5
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1664-042X
J9 FRONT PHYSIOL
JI Front. Physiol.
PD FEB 21
PY 2025
VL 16
AR 1504778
DI 10.3389/fphys.2025.1504778
PG 12
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA Z4Z8K
UT WOS:001439016000001
PM 40061456
OA gold
DA 2025-06-11
ER

PT J
AU Zhou, Q
   Song, N
   Wang, SQ
   Wang, Y
   Zhao, YK
   Zhu, XD
AF Zhou, Qi
   Song, Ning
   Wang, Shi-qi
   Wang, Yan
   Zhao, Yi-Kun
   Zhu, Xiang-dong
TI Effect of Gegen Qinlian Decoction on Hepatic Gluconeogenesis in ZDF Rats
   with Type 2 Diabetes Mellitus Based on the Farnesol X
   Receptor/Ceramide Signaling Pathway Regulating Mitochondrial Metabolism
   and Endoplasmic Reticulum Stress
SO EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Article
ID INSULIN-RESISTANCE; FXR; ACID
AB Background. Type 2 diabetes mellitus (T2DM) is a kind of disorder of glucose and lipid metabolism with the main clinical manifestation of long-term higher blood glucose level than the normal value. Farnesol X receptor (FXR)/ceramide signaling pathway plays an important role in regulating cholesterol metabolism, lipid homeostasis, and the absorption of fat and vitamins in diet. Gegen Qinlian Decoction (GQD) is a classical herbal formula, which has a good clinical therapeutic effect on diabetes-related metabolic syndrome. Objective. To investigate the effect of Gegen Qinlian Decoction (GQD) on hepatic gluconeogenesis in obese T2DM rats based on the FXR/ceramide signaling pathway regulating mitochondrial metabolism and endoplasmic reticulum stress (ERS). Methods. ZDF (fa/fa) rats were fed with high-fat diet to establish the T2DM model; GQD was given to T2DM model rats by gavage; changes of the general state and body weight of rats were recorded; fasting blood glucose was detected; blood insulin, blood ceramide, glycosylated hemoglobin in blood, acetyl CoA in liver mitochondria, and bile salt lyase in intestinal tissue were detected by ELISA. The content of T-beta-MCA in blood was detected by LC-MS; the content of glycogen in liver tissue was detected by PAS staining; the expression of FXR, Sptlc2, and Smpd3 in ileum tissue, P-PERK, ATF6 alpha, GRP78 BIP, and P-IRE1 in the liver, and CS and PC protein in liver mitochondria was detected by immunohistochemistry and western blot assay. The mRNA expression levels of FXR, Sptlc2, and Smpd3 in the ileum, PERK, ATF6 alpha, GRP78 BIP, and IRE1 in the liver, and CS and PC in liver mitochondria were detected by qRT-PCR. Results. GQD can improve the general state of T2DM rats, slow down their weight gain, reduce the levels of fasting blood glucose, fasting insulin, glycosylated hemoglobin, blood ceramide, bile salt hydrolase in intestinal tissue, and acetyl CoA in liver mitochondria of T2DM rats, and increase the contents of liver glycogen and T-beta-MCA in blood of T2DM rats. At the molecular level, GQD can inhibit the expression levels of FXR, Sptlc2, and Smpd3 in the ileum of T2DM rats and the protein and mRNA expression levels of oxidative stress-related factors in the liver. At the same time, GQD can increase the expression of CS and reduce the expression of PC in liver mitochondria of T2DM rats. Conclusion. GQD can inhibit the FXR/ceramide signaling pathway, regulate endoplasmic reticulum stress, enhance the CS activity of liver mitochondria, reduce the acetyl CoA level and PC activity of liver mitochondria, inhibit hepatic gluconeogenesis, protect islet beta-cells, and control blood glucose.
C1 [Zhou, Qi; Song, Ning; Wang, Yan; Zhao, Yi-Kun; Zhu, Xiang-dong] Gansu Univ Chinese Med, Lanzhou 730000, Gansu, Peoples R China.
   [Wang, Shi-qi] Third Peoples Hosp Gansu Prov, Lanzhou 730000, Gansu, Peoples R China.
C3 Gansu University of Chinese Medicine
RP Zhu, XD (corresponding author), Gansu Univ Chinese Med, Lanzhou 730000, Gansu, Peoples R China.
EM zhuxiangdong33@163.com
RI Wang, Shiqi/LEM-7616-2024
OI zhu, xiangdong/0000-0001-9641-3982; Zhou, Qi/0000-0003-2998-9898; Zhao,
   YiKun/0000-0001-7436-1050
FU Talent Innovation and Entrepreneurship Project of Lanzhou City
   [2019-RC-100]
FX This work was supported by the Talent Innovation and Entrepreneurship
   Project of Lanzhou City (no. 2019-RC-100).
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NR 36
TC 11
Z9 18
U1 2
U2 27
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1741-427X
EI 1741-4288
J9 EVID-BASED COMPL ALT
JI Evid.-based Complement Altern. Med.
PD AUG 10
PY 2021
VL 2021
AR 9922292
DI 10.1155/2021/9922292
PG 13
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA UD8TU
UT WOS:000687476100001
PM 34422083
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Lu, JY
   Ma, XJ
   Zhang, L
   Mo, YF
   Ying, LW
   Lu, W
   Zhu, W
   Bao, YQ
   Zhou, J
AF Lu, Jingyi
   Ma, Xiaojing
   Zhang, Lei
   Mo, Yifei
   Ying, Lingwen
   Lu, Wei
   Zhu, Wei
   Bao, Yuqian
   Zhou, Jian
TI Glycemic variability assessed by continuous glucose monitoring and the
   risk of diabetic retinopathy in latent autoimmune diabetes of the adult
   and type 2 diabetes
SO JOURNAL OF DIABETES INVESTIGATION
LA English
DT Article
DE Diabetic retinopathy; Glycemic variability; Latent autoimmune diabetes
   of the adult
ID OXIDATIVE STRESS; MICROVASCULAR COMPLICATIONS; ENDOTHELIAL FUNCTION;
   AUTOANTIBODIES; ASSOCIATION; PROGRESSION; PHENOTYPE; SEVERITY; MELLITUS;
   DISEASE
AB Aims/Introduction The relationship between glycemic variability (GV) and diabetic complications has gained much interest and remains under debate. Furthermore, the association of GV with diabetic complications has not been examined in latent autoimmune diabetes of the adult (LADA). Therefore, we evaluated the relationships among several metrics of GV with diabetic retinopathy (DR) in patients with LADA and type 2 diabetes mellitus. Materials and Methods A total of 192 patients with LADA and 2,927 patients with type 2 diabetes mellitus were enrolled. After continuous glucose monitoring for 72 h, three metrics of GV including standard deviation, coefficient of variation and mean amplitude of glycemic excursions were calculated. DR was assessed by fundus photography performed with a digital non-mydriatic camera. Results The prevalence of DR was 20.3 and 26.4% in LADA and type 2 diabetes mellitus patients (P < 0.001), respectively. Generally, LADA patients had fewer cardiometabolic risk factors than type 2 diabetes mellitus patients, and all GV metrics were significantly higher in LADA than in type 2 diabetes mellitus. In the multivariate logistic regression analysis, no metrics for GV were identified as independent risk factors of DR (standard deviation: P = 0.175; coefficient of variation: P = 0.769; mean amplitude of glycemic excursions: P = 0.388) in LADA. However, the standard deviation was significantly associated with DR (OR 1.15, P = 0.017) in patients with type 2 diabetes mellitus after adjusting for confounders. The independent relationships of coefficient of variation and mean amplitude of glycemic excursions with DR (P = 0.194 and P = 0.251, respectively) did not reach statistical significance in type 2 diabetes mellitus. Conclusions GV is more strongly associated with DR in type 2 diabetes than in LADA, suggesting that different glucose-lowering strategies should be used for these two types of diabetes.
C1 [Lu, Jingyi; Ma, Xiaojing; Zhang, Lei; Mo, Yifei; Ying, Lingwen; Lu, Wei; Zhu, Wei; Bao, Yuqian; Zhou, Jian] Shanghai Jiao Tong Univ, Dept Endocrinol & Metab,Affiliated Peoples Hosp 6, Shanghai Clin Ctr Diabet,Shanghai Key Lab Diabet, Shanghai Key Clin Ctr Metab Dis,Shanghai Diabet I, Shanghai, Peoples R China.
C3 Shanghai Jiao Tong University
RP Zhou, J (corresponding author), Shanghai Jiao Tong Univ, Dept Endocrinol & Metab,Affiliated Peoples Hosp 6, Shanghai Clin Ctr Diabet,Shanghai Key Lab Diabet, Shanghai Key Clin Ctr Metab Dis,Shanghai Diabet I, Shanghai, Peoples R China.
EM zhoujian@sjtu.edu.cn
RI Zhu, Wei/J-3329-2012; Lu, Wei/C-8409-2012; Lu, jingyi/KYP-7679-2024
FU Shanghai Municipal Education Commission-Gaofeng Clinical Medicine Grant
   Support [20161430]
FX This work was funded by the Shanghai Municipal Education
   Commission-Gaofeng Clinical Medicine Grant Support (20161430). We thank
   all of the involved clinicians, nurses and technicians for dedicating
   their time and skills to the completion of this study.
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NR 24
TC 48
Z9 49
U1 0
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2040-1116
EI 2040-1124
J9 J DIABETES INVEST
JI J. Diabetes Investig.
PD MAY
PY 2019
VL 10
IS 3
BP 753
EP 759
DI 10.1111/jdi.12957
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA HW3HS
UT WOS:000466582300025
PM 30306722
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Rosmond, R
   Holm, G
   Björntorp, P
AF Rosmond, R
   Holm, G
   Björntorp, P
TI Food-induced cortisol secretion in relation to anthropometric, metabolic
   and haemodynamic variables in men
SO INTERNATIONAL JOURNAL OF OBESITY
LA English
DT Article
DE HPA axis; cortisol; food intake; metabolic syndrome
ID BODY-FAT DISTRIBUTION; PITUITARY-ADRENAL AXIS; MIDDLE-AGED MEN; SALIVARY
   CORTISOL; ABDOMINAL OBESITY; STRESS; WOMEN; NEUROENDOCRINOLOGY;
   ENDOCRINE; GROWTH
AB OBJECTIVE: To assess the relationships between the regulation of diurnal and food-induced cortisol secretion and anthropometric, metabolic and haemodynamic variables in middle-aged men.
   SUBJECTS AND METHOD: Salivary cortisols were collected repeatedly (n = 7) over an ordinary working day (8 a,m. to 11 p.m.) in a randomly selected population of 284 men, aged 51 y. A standardized lunch was provided, and an overnight low-dose dexamethasone suppression test was performed. These measurements were correlate with the anthropometric factors-body mass index, BMI, (kg/m(2)), waist-to-hip ratio (WHR) and abdominal sagittal diameter; the metabolic factors-fasting insulin and glucose as well as their ratio, and triglycerides; and the haemodynamic factors-systolic and diastolic blood pressures and heart rate.
   RESULTS: As reported previously two principal types of salivary cortisol secretory patterns can be singled out, one characterized by high morning cortisol levels, a normal circadian rhythm and feedback regulation (dexamethasone) along with a brisk cortisol response to lunch, and another, found in a limited number of men, characterized by low morning cortisols, the absence of a circadian rhythm, a relative resistance to dexamethasone inhibition and a poor lunch-induced cortisol response. The normal cortisol secretory pattern showed negative associations with BMI (P < 0.05), WHR (P < 0.01), and blood pressures (P < 0.001). After stimulation by food intake, negative relationships were found with all obesity measurements, insulin, insulin/glucose ratio, triglycerides, blood pressures and heart rate (all P < 0.001). These results suggest that normally regulated cortisol is associated with a favourable somatic health. In contrast, after food intake cortisol secretion, based on an abnormal cortisol secretory pattern, showed consistent positive associations with obesity measurements, insulin, glucose and insulin/glucose ratio, triglycerides, blood pressures and heart rate (all P < 0.001).
   CONCLUSIONS: A normal HPA axis regulation is associated with excellent health anthropometric, metabolic and haemodynamic variables, particularly visible after the physiological stimulus of food intake. This is, however, not the case in men with perturbed HPA axis function where associations in these somatic variables become exaggerated by food intake. We have previously reported that perceived stress-related cortisol is associated with abnormalities in the variables mentioned above, both with a normal and, particularly, with an abnormal function of the HPA axis. It Is thus apparent that perceived stress and food intake show separate associations to somatic variables with a normally functioning HPA axis, while with an abnormal regulation of this axis both perceived stress and food intake exaggerate associations to abnormal somatic variables.
C1 Gothenburg Univ, Sahlgrenska Hosp, Dept Heart & Lung Dis, S-41345 Gothenburg, Sweden.
C3 Sahlgrenska University Hospital; University of Gothenburg
RP Gothenburg Univ, Sahlgrenska Hosp, Dept Heart & Lung Dis, S-41345 Gothenburg, Sweden.
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TC 67
Z9 74
U1 0
U2 11
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0307-0565
EI 1476-5497
J9 INT J OBESITY
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PD APR
PY 2000
VL 24
IS 4
BP 416
EP 422
DI 10.1038/sj.ijo.0801173
PG 7
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 300RR
UT WOS:000086266400004
PM 10805497
DA 2025-06-11
ER

PT J
AU Naseri, K
   Saadati, S
   Yari, Z
   Asbaghi, O
   Hezaveh, ZS
   Mafi, D
   Hoseinian, P
   Ashtary-Larky, D
   Hekmatdoost, A
   de Courten, B
AF Naseri, Kaveh
   Saadati, Saeede
   Yari, Zahra
   Asbaghi, Omid
   Hezaveh, Zohre Sajadi
   Mafi, Davood
   Hoseinian, Pooria
   Ashtary-Larky, Damoon
   Hekmatdoost, Azita
   de Courten, Barbora
TI Beneficial effects of probiotic and synbiotic supplementation on some
   cardiovascular risk factors among individuals with prediabetes and type
   2 diabetes mellitus: A grade-assessed systematic review, meta-analysis,
   and meta-regression of randomized clinical trials
SO PHARMACOLOGICAL RESEARCH
LA English
DT Review
DE Probiotic; Synbiotic; T2DM; Prediabetes; Lipid profile; Blood pressure;
   Anthropometric indices
ID FERMENTED MILK KEFIR; BODY-MASS INDEX; DOUBLE-BLIND; LIPID PROFILE;
   GLYCEMIC CONTROL; GUT MICROBIOTA; BLOOD-PRESSURE; SOY MILK; INSULIN
   METABOLISM; OXIDATIVE STRESS
AB Previous studies suggested that probiotics/synbiotics administration exerts some beneficial effects on cardiometabolic risk factors. However, the results from trials have been inconsistent. This study aimed to identify the impact of probiotic and synbiotic supplements on cardiovascular health factors in patients with type 2 diabetes mellitus (T2DM) and prediabetes We searched PubMed/MEDLINE, Web of Science, and Scopus up to February 2022 to identify eligible RCTs. Estimating 95 % confidence (CI) and the weighted mean difference (WMD) for weight, body mass index (BMI), waist circumferences (WC), triglyceride (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), systolic blood pressure (SBP), and diastolic blood pressure (DBP), the random-effects model was used. In the current meta-analysis, 54 RCTs were included. With the probiotic/synbiotics intervention, several parameters changed significantly, including weight (WMD: -0.38, 95 % CI: -0.63 to -0.12 Kg), TG (WMD:-19.08, 95 % CI: -27.65 to-10.51 mg/ dl), TC (WMD: -10.46, 95 % CI: -15.19 to-5.72 mg/dl), LDL-C (WMD: -4.87, 95 % CI: -7.65 to-2.09 mg/dl), HDL-C (WMD: -2.70, 95 % CI: 1.33-4.07 mg/dl), SBP (WMD: -3.81, 95 % CI: -6.24 to-1.38 mmHg), and DBP (WMD: -2.01, 95 % CI: -3.12 to-0.91 mmHg). In the subgroup analysis, probiotics/synbiotics supplementation resulted in a greater change in lipid profile components in T2DM patients. Weight and BMI reduced only after synbiotic supplementation. We found that the administration of probiotics and synbiotics had beneficial effects on lipid profiles, anthropometric indices, and blood pressure in individuals with T2DM.
C1 [Naseri, Kaveh] Shahid Beheshti Univ Med Sci, Res Inst Gastroenterol & Liver Dis, Gastroenterol & Liver Dis Res Ctr, Tehran, Iran.
   [Saadati, Saeede; de Courten, Barbora] Monash Univ, Sch Clin Sci, Dept Med, Melbourne, Australia.
   [Yari, Zahra] Shahid Beheshti Univ Med Sci, Natl Nutr & Food Technol Res Inst, Dept Nutr Res, Tehran, Iran.
   [Asbaghi, Omid; Hezaveh, Zohre Sajadi] Shahid Beheshti Univ Med Sci, Canc Res Ctr, Tehran, Iran.
   [Mafi, Davood; Hoseinian, Pooria] Shahid Beheshti Univ Med Sci, Fac Med, Tehran, Iran.
   [Ashtary-Larky, Damoon] Ahvaz Jundishapur Univ Med Sci, Nutr & Metab Dis Res Ctr, Ahvaz, Iran.
   [Hekmatdoost, Azita] Shahid Beheshti Univ Med Sci, Natl Nutr & Food Technol Res Inst, Dept Clin Nutr & Dietet, Tehran, Iran.
   [de Courten, Barbora] RMIT Univ, Sch Hlth & Biomed Sci, Bundoora, Australia.
   [de Courten, Barbora] Sch Clin Sci, Dept Med, 246 Clayton Rd, Clayton, Vic 3168, Australia.
C3 Shahid Beheshti University Medical Sciences; Monash University; Shahid
   Beheshti University Medical Sciences; Shahid Beheshti University Medical
   Sciences; Shahid Beheshti University Medical Sciences; Ahvaz Jundishapur
   University of Medical Sciences (AJUMS); Shahid Beheshti University
   Medical Sciences; Royal Melbourne Institute of Technology (RMIT)
RP de Courten, B (corresponding author), Sch Clin Sci, Dept Med, 246 Clayton Rd, Clayton, Vic 3168, Australia.
EM barbora.decourten@monash.edu
RI Saadati, Saeede/GRO-7406-2022; Yari, Zahra/P-6594-2019; Ashtary Larky,
   Damoon/T-4192-2019; Sajadi'Hezaveh, Zohreh/LEM-1778-2024; de Courten,
   Barbora/B-3308-2012; Hekmatdoost, Azita/AGM-6497-2022
OI yari, zahra/0000-0003-2796-2413; Ashtary Larky,
   Damoon/0000-0001-7968-6110
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NR 132
TC 32
Z9 32
U1 2
U2 25
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 1043-6618
EI 1096-1186
J9 PHARMACOL RES
JI Pharmacol. Res.
PD AUG
PY 2022
VL 182
AR 106288
DI 10.1016/j.phrs.2022.106288
EA JUN 2022
PG 18
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 2Q5BE
UT WOS:000820436800007
PM 35680009
DA 2025-06-11
ER

PT J
AU Tripp, ML
   Dahlberg, CJ
   Eliason, S
   Lamb, JJ
   Ou, JJ
   Gao, W
   Bhandari, J
   Graham, D
   Dudleenamjil, E
   Babish, JG
AF Tripp, Matthew L.
   Dahlberg, Clinton J.
   Eliason, Sarah
   Lamb, Joseph J.
   Ou, Joseph J.
   Gao, Wei
   Bhandari, Jay
   Graham, David
   Dudleenamjil, Enkhmart
   Babish, John G.
TI A Low-Glycemic, Mediterranean Diet and Lifestyle Modification Program
   with Targeted Nutraceuticals Reduces Body Weight, Improves
   Cardiometabolic Variables and Longevity Biomarkers in Overweight
   Subjects: A 13-Week Observational Trial
SO JOURNAL OF MEDICINAL FOOD
LA English
DT Article
DE low-glycemic load diet; nitric oxide; obesity; polyphenols
ID CALORIE RESTRICTION; OXIDATIVE STRESS; OBESE ADULTS; RISK; FATNESS;
   CANCER; FIBER; NONOBESE; GLUCOSE
AB Among the comorbidities of high body mass index, cardiovascular disease continued to be the leading cause of death and disability globally in 2015, while type 2 diabetes remained second. The primary objectives of this observational study were to confirm the safety, tolerability, and efficacy of our calorie-restricted Mediterranean diet with targeted dietary supplementation (PROG1) using globally recognized dietary supplementation. Fifty healthy overweight and obese subjects with cardiometabolic risk factors were assigned a modified Mediterranean diet, including protein shakes and targeted supplementation (PROG2), providing similar to 68-76% of subject estimated calorie requirements. Salivary nitrite was assessed weekly and key cardiometabolic metrics were recorded at baseline and weeks 9 and 13. PROG2 was well tolerated with 86% compliance. The most common adverse effects were bloating, flatulence, and constipation, which were self-limiting. Subjects exhibited decreases (P < .01) from baseline of 12% in body weight, 18% in body fat, and 8.8% in waist circumference. Total cholesterol (TC), low-density lipoprotein (LDL) cholesterol, and triglycerides (TG) were reduced (P < .01), respectively, 19%, 22%, and 40%. Lipid ratios of TC/high-density lipoprotein (HDL), TG/HDL, and oxidized LDL (oxLDL)/HDL were decreased 15% (P < .01), 35% (P < .01), and 13% (P < .05), respectively. Inflammation biomarkers, oxLDL and high-sensitivity C-reactive protein, were reduced 17% (P < .01) and 30% (P < .05), respectively. Reductions of 9.0% for systolic (P < .01) and 12% (P < .01) for diastolic blood pressure were noted. In concert, the nitrogen dioxide salivary biomarker for nitric oxide was increased relative to baseline. PROG2 produced a dramatic 50% reduction in subjects meeting cardiometabolic syndrome criteria and a 38% decrease in Framingham 10-year cardiovascular risk. These results confirmed our previous findings that the addition of targeted nutraceutical supplementation to a calorie-restricted Mediterranean diet with lifestyle modifications improves multiple longevity risk factors more effectively than diet and lifestyle modification alone.
C1 [Tripp, Matthew L.; Dahlberg, Clinton J.; Eliason, Sarah; Ou, Joseph J.; Gao, Wei; Bhandari, Jay; Graham, David; Dudleenamjil, Enkhmart] Nat Sunshine, Hughes Ctr Res & Innovat, Lehi, UT USA.
   [Lamb, Joseph J.] Personalized Med Inc, 9770 44th Ave NW,Suite 102, Gig Harbor, WA USA.
   [Babish, John G.] Bio Nexus Ltd, 508 White Church Rd, Brooktondale, NY 14817 USA.
RP Babish, JG (corresponding author), Bio Nexus Ltd, 508 White Church Rd, Brooktondale, NY 14817 USA.
EM jgb7@cornell.edu
OI Gao, Wei/0000-0003-0843-1449
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NR 49
TC 12
Z9 12
U1 2
U2 21
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1096-620X
EI 1557-7600
J9 J MED FOOD
JI J. Med. Food
PD MAY 1
PY 2019
VL 22
IS 5
BP 479
EP 489
DI 10.1089/jmf.2018.0063
PG 11
WC Chemistry, Medicinal; Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Food Science & Technology; Nutrition &
   Dietetics
GA HY2PC
UT WOS:000467964100006
PM 31084538
DA 2025-06-11
ER

PT J
AU Ramos, JS
   Dalleck, LC
   Tjonna, AE
   Beetham, KS
   Coombes, JS
AF Ramos, Joyce S.
   Dalleck, Lance C.
   Tjonna, Arnt Erik
   Beetham, Kassia S.
   Coombes, Jeff S.
TI The Impact of High-Intensity Interval Training Versus Moderate-Intensity
   Continuous Training on Vascular Function: a Systematic Review and
   Meta-Analysis
SO SPORTS MEDICINE
LA English
DT Review
ID FLOW-MEDIATED DILATATION; ENDOTHELIUM-DEPENDENT VASODILATION; ALL-CAUSE
   MORTALITY; NITRIC-OXIDE; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   SHEAR-STRESS; BRACHIAL-ARTERY; BLOOD-PRESSURE; LOW-VOLUME
AB Background Vascular dysfunction is a precursor to the atherosclerotic cascade, significantly increasing susceptibility to cardiovascular events such as myocardial infarction or stroke. Previous studies have revealed a strong relationship between vascular function and cardiorespiratory fitness (CRF). Thus, since high-intensity interval training (HIIT) is a potent method of improving CRF, several small randomized trials have investigated the impact on vascular function of HIIT relative to moderate-intensity continuous training (MICT).
   Objective The aim of this study was to systematically review the evidence and quantify the impact on vascular function of HIIT compared with MICT.
   Methods Three electronic databases (PubMed, Embase, and MEDLINE) were searched (until May 2014) for randomized trials comparing the effect of at least 2 weeks ofHIITandMICT on vascular function. HIIT protocols involved predominantly aerobic exercise at a high intensity, interspersed with active or passive recovery periods. We performed a meta-analysis to compare the mean difference in the change in vascular function assessed via brachial artery flow-mediated dilation (FMD) from baseline to post-intervention between HIIT and MICT. The impact of HIIT versusMICTonCRF, traditional cardiovascular disease (CVD) risk factors, and biomarkers associated with vascular function (oxidative stress, inflammation, and insulin resistance) was also reviewed across included studies.
   Results Seven randomized trials, including 182 patients, met the eligibility criteria and were included in the meta-analysis. A commonly used HIIT prescription was four intervals of 4 min (4 9 4 HIIT) at 85-95 % of maximum or peak heart rate (HRmax/peak), interspersed with 3 min of active recovery at 60-70 % HRmax/peak, three times per week for 12-16 weeks. Brachial artery FMD improved by 4.31 and 2.15 % following HIIT and MICT, respectively. This resulted in a significant (p < 0.05) mean difference of 2.26 %. HIIT also had a greater tendency than MICT to induce positive effects on secondary outcome measures, including CRF, traditional CVD risk factors, oxidative stress, inflammation, and insulin sensitivity.
   Conclusion HIIT is more effective at improving brachial artery vascular function than MICT, perhaps due to its tendency to positively influence CRF, traditional CVD risk factors, oxidative stress, inflammation, and insulin sensitivity. However, the variability in the secondary outcome measures, coupledwith the small sample sizes in these studies, limits this finding. Nonetheless, this review suggests that 4 9 4 HIIT, three times per week for at least 12 weeks, is a powerful form of exercise to enhance vascular function.
C1 [Ramos, Joyce S.; Beetham, Kassia S.; Coombes, Jeff S.] Univ Queensland, Sch Human Movement & Nutr Sci, Brisbane, Qld 4072, Australia.
   [Dalleck, Lance C.] Western State Colorado Univ, Recreat Exercise & Sport Sci Dept, Gunnison, CO USA.
   [Tjonna, Arnt Erik] Norwegian Univ Sci & Technol NTNU, Dept Circulat & Med Imaging, KG Jebsen Ctr Exercise Med, Trondheim, Norway.
C3 University of Queensland; Norwegian University of Science & Technology
   (NTNU)
RP Coombes, JS (corresponding author), Univ Queensland, Sch Human Movement & Nutr Sci, Rm 535,HMNS Bldg, Brisbane, Qld 4072, Australia.
EM jcoombes@uq.edu.au
RI Coombes, Jeff/F-1764-2010
OI Coombes, Jeff/0000-0002-6990-3596; Beetham, Kassia/0000-0003-4657-7668;
   Ramos, Joyce/0000-0001-8693-6800
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NR 77
TC 473
Z9 525
U1 11
U2 292
PU ADIS INT LTD
PI NORTHCOTE
PA 5 THE WAREHOUSE WAY, NORTHCOTE 0627, AUCKLAND, NEW ZEALAND
SN 0112-1642
EI 1179-2035
J9 SPORTS MED
JI Sports Med.
PD MAY
PY 2015
VL 45
IS 5
BP 679
EP 692
DI 10.1007/s40279-015-0321-z
PG 14
WC Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Sport Sciences
GA CJ6JY
UT WOS:000355601300006
PM 25771785
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Parsanathan, R
   Jain, SK
AF Parsanathan, Rajesh
   Jain, Sushil K.
TI Glucose-6-phosphate dehydrogenase deficiency increases cell adhesion
   molecules and activates human monocyte-endothelial cell adhesion:
   Protective role of L-cysteine
SO ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
LA English
DT Article
DE Endothelial dysfunction; Glucose-6-phosphate dehydrogenase deficiency;
   Cell adhesion molecules; Oxidative stress; Glutathione; L-cysteine
ID GLUCOSE INHIBITS GLUCOSE-6-PHOSPHATE-DEHYDROGENASE; CARDIOVASCULAR
   RISK-FACTORS; TUMOR-NECROSIS-FACTOR; OXIDATIVE STRESS; PLASMA-LEVELS;
   CHEMOATTRACTANT PROTEIN-1; BUTHIONINE SULFOXIMINE; RACIAL-DIFFERENCES;
   DIABETES-MELLITUS; N-ACETYLCYSTEINE
AB Glucose-6-phosphate dehydrogenase is a major enzyme that supplies the reducing agent nicotinamide adenine dinucleotide phosphate hydrogen (NADPH), which is required to recycle oxidized/glutathione disulfide (GSSH) to reduced glutathione (GSH). G6PD-deficient cells are susceptible to oxidative stress and a deficiency of GSH. Endothelial dysfunction is characterized by the loss of nitric oxide (NO) bioavailability, which regulates leukocyte adhesion to endothelium. G6PD-deficient endothelial cells (EC) demonstrate reduced expression of endothelial nitric oxide synthase (eNOS) and NO levels along with reduced GSH. Whether G6PD deficiency plays any role in EC dysfunction is unknown. The chronic inflammation commonly seen in those with metabolic syndrome, characterized by elevated levels of tumor necrosis factor (TNF) and monocyte chemoattractant protein 1 (MCP-1), provided an incentive for investigation of these cytokines as well. A GSH/G6PD-deficient model was created using human umbilical vein endothelial cells (HUVEC) treated with either buthionine sulfoximine (BSO), a pharmacological inhibitor of the rate-limiting enzyme of GSH biosynthesis (gamma-glutamylcysteine synthetase), or with 6-aminonicotinamide (6-AN), an inhibitor of G6PD or G6PD siRNA. Normal and G6PD-deficient cells were also treated with pro-atherosclerotic stimuli such as high glucose, TNF, and MCP-1. After inhibiting or knocking down G6PD/GSH, the capacity of endothelial cells for monocyte recruitment was assessed by determining the expression of the adhesion molecules intercellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion molecule 1 (VCAM-1), which was upregulated by G6PD deficiency and accompanied by the presence of the oxidative stress markers NADPH oxidase 4 (NOX4), inducible nitric oxide synthase (iNOS), and reactive oxygen species (ROS). Treatment with the inhibitors BSO and 6-AN caused increased levels of adhesion molecule mRNA and monocyte-EC adhesion. Following treatment with high glucose, G6PD-deficient cells showed an increase in levels of ICAM-1 and VCAM-1 mRNA, as well as monocyte-EC adherence, compared with results seen in control cells. Treatment with L-cysteine (a precursor of GSH) protected endothelial cells by increasing GSH and attenuating ROS, ICAM-1, VCAM-1, and monocyte-EC adhesion. These results suggest that G6PD/GSH deficiency plays a role in endothelial dysfunction and that supplementation with L-cysteine can restore GSH levels and reduce the EC activation markers in G6PD-deficient conditions.
C1 [Parsanathan, Rajesh; Jain, Sushil K.] Louisiana State Univ, Hlth Sci Ctr Shreveport, Dept Pediat, 1501 Kings Highway, Shreveport, LA 71130 USA.
   [Parsanathan, Rajesh; Jain, Sushil K.] Louisiana State Univ, Hlth Sci Ctr Shreveport, Ctr Cardiovasc Dis & Sci, 1501 Kings Highway, Shreveport, LA 71130 USA.
C3 Louisiana State University System; Louisiana State University Health
   Sciences Center at Shreveport; Louisiana State University System;
   Louisiana State University Health Sciences Center at Shreveport
RP Jain, SK (corresponding author), Louisiana State Univ, Hlth Sci Ctr Shreveport, Dept Pediat, 1501 Kings Highway, Shreveport, LA 71130 USA.
EM sjain@lsuhsc.edu
RI Parsanathan, Rajesh/AAC-5072-2019
FU Malcolm W. Feist Cardiovascular Research Fellowship; Center for
   Cardiovascular Diseases and Sciences (CCDS), LSUHSC, Shreveport
FX The authors are supported by grants from the Malcolm W. Feist
   Cardiovascular Research Fellowship to Rajesh Parsanathan and Endowed
   Chair in Diabetes to Sushil K. Jain from the Center for Cardiovascular
   Diseases and Sciences (CCDS), LSUHSC, Shreveport. We also thank the
   Research Core Facility at Louisiana State University Health Sciences
   Center in Shreveport for generation of the gene expression data. Ms.
   Paula Polk kindly assisted with the 384-well block installation in the
   Applied Biosystems 7900HT Fast Real-Time PCR System. We also thank Dr.
   Saikolappan Sankaralingam, a postdoctoral fellow in the Department of
   Biochemistry and Molecular Biology, and Mr. Fengtian Wang, LSUHSC, for
   providing technical assistance with the Cytation 5 Cell Imaging
   Multi-Mode Reader. The authors thank Ms. Georgia Morgan for excellent
   editing.
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NR 90
TC 30
Z9 32
U1 0
U2 18
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0003-9861
EI 1096-0384
J9 ARCH BIOCHEM BIOPHYS
JI Arch. Biochem. Biophys.
PD MAR 15
PY 2019
VL 663
BP 11
EP 21
DI 10.1016/j.abb.2018.12.023
PG 11
WC Biochemistry & Molecular Biology; Biophysics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics
GA HN3LT
UT WOS:000460085600002
PM 30582899
DA 2025-06-11
ER

PT J
AU Sperkowska, B
   Murawska, J
   Przybylska, A
   Gackowski, M
   Kruszewski, S
   Durmowicz, M
   Rutkowska, D
AF Sperkowska, Beata
   Murawska, Joanna
   Przybylska, Anna
   Gackowski, Marcin
   Kruszewski, Stefan
   Durmowicz, Maciej
   Rutkowska, Dorota
TI Cardiovascular Effects of Chocolate and Wine-Narrative Review
SO NUTRIENTS
LA English
DT Article
DE bioactive compounds; chocolate; wine; cardiovascular benefits;
   cardiovascular risk; drug-food interactions; inflammation;
   atherosclerosis; oxidative stress
ID PERIPHERAL ARTERY-DISEASE; MODERATE ALCOHOL INTAKE; RED WINE; DARK
   CHOCOLATE; RISK-FACTORS; HEART-FAILURE; CARDIOMETABOLIC RISK;
   INFLAMMATORY MARKERS; POSTMENOPAUSAL WOMEN; DIETARY POLYPHENOLS
AB The consumption of food for pleasure is mainly associated with adverse health effects. This review was carried out to verify recent reports on the impact of chocolate and wine consumption on cardiovascular health, with a particular focus on atherosclerosis. On one side, these products have proven adverse effects on the cardiovascular system, but on the other hand, if consumed in optimal amounts, they have cardiovascular benefits. The submitted data suggest that the beneficial doses are 30-50 g and 130/250 mL for chocolate and wine, respectively, for women and men. The accumulated evidence indicates that the active ingredients in the products under consideration in this review are phenolic compounds, characterized by anti-inflammatory, antioxidant, and antiplatelet properties. However, there are also some reports of cardioprotective properties of other compounds such as esters, amines, biogenic amines, amino acids, fatty acids, mineral ingredients, and vitamins. Our narrative review has shown that in meta-analyses of intervention studies, consumption of chocolate and wine was positively associated with the beneficial outcomes associated with the cardiovascular system. In contrast, the assessment with the GRADE (Grading of Recommendations Assessment, Development and Evaluation) scale did not confirm this phenomenon. In addition, mechanisms of action of bioactive compounds present in chocolate and wine depend on some factors, such as age, sex, body weight, and the presence of additional medical conditions. Patients using cardiovascular drugs simultaneously with both products should be alert to the risk of pharmacologically relevant interactions during their use. Our narrative review leads to the conclusion that there is abundant evidence to prove the beneficial impact of consuming both products on cardiovascular health, however some evidence still remains controversial. Many authors of studies included in this review postulated that well-designed, longitudinal studies should be performed to determine the effects of these products and their components on atherosclerosis and other CVD (Cardiovascular Disease) disease.
C1 [Sperkowska, Beata; Murawska, Joanna; Przybylska, Anna; Gackowski, Marcin] Nicolaus Copernicus Univ Torun, Fac Pharm, L Rydygier Coll Med Bydgoszcz, Dept Toxicol & Bromatol, A Jurasza 2 St, PL-85089 Torun, Poland.
   [Kruszewski, Stefan] Nicolaus Copernicus Univ Torun, Fac Pharm, L Rydygier Coll Med Bydgoszcz, Biophys Dept, Jagiellonska 13 St, PL-85067 Torun, Poland.
   [Durmowicz, Maciej] Nicolaus Copernicus Univ Torun, Fac Hlth Sci, L Rydygier Coll Med, Dept Physiotherapy, Technikow 3 St, PL-85094 Torun, Poland.
   [Rutkowska, Dorota] Nicolaus Copernicus Univ Torun, Fac Med, L Rydygier Coll Med Bydgoszcz, Lab Med Educ, St Florians 12 St, PL-85030 Torun, Poland.
C3 Nicolaus Copernicus University; Nicolaus Copernicus University; Nicolaus
   Copernicus University; Nicolaus Copernicus University
RP Sperkowska, B (corresponding author), Nicolaus Copernicus Univ Torun, Fac Pharm, L Rydygier Coll Med Bydgoszcz, Dept Toxicol & Bromatol, A Jurasza 2 St, PL-85089 Torun, Poland.
EM beata.sperkowskai@cm.umk.pl; joanna.murawska94@wp.pl; aniacm@cm.umk.pl;
   marcin.gackowski@cm.umk.pl; skrusz@cm.umk.pl;
   maciej.durmowicz@cm.umk.pl; dorota.rutkowska@cm.umk.pl
RI Gackowski, Marcin/ACB-8262-2022; Przybylska, Anna/P-5156-2015;
   Sperkowska, Beata/P-4951-2015; Kruszewski, Stefan/H-3265-2014
OI Gackowski, Marcin/0000-0001-9176-7108; Sperkowska,
   Beata/0000-0001-8956-6120; Przybylska, Anna/0000-0002-7597-8156;
   Murawska, Joanna Anna/0000-0001-7564-938X; Kruszewski,
   Stefan/0000-0002-8050-6946
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NR 183
TC 14
Z9 15
U1 2
U2 44
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD DEC
PY 2021
VL 13
IS 12
AR 4269
DI 10.3390/nu13124269
PG 29
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA XX8ZX
UT WOS:000736577500001
PM 34959821
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Billany, RE
   Vadaszy, N
   Bishop, NC
   Wilkinson, TJ
   Adenwalla, SF
   Robinson, KA
   Croker, K
   Brady, EM
   Wormleighton, JV
   Parke, KS
   Cooper, NJ
   Webster, AC
   Barratt, J
   McCann, GP
   Burton, JO
   Smith, AC
   Graham-Brown, MPM
AF Billany, Roseanne E.
   Vadaszy, Noemi
   Bishop, Nicolette C.
   Wilkinson, Thomas J.
   Adenwalla, Sherna F.
   Robinson, Katherine A.
   Croker, Kathryn
   Brady, Emer M.
   Wormleighton, Joanne, V
   Parke, Kelly S.
   Cooper, Nicola J.
   Webster, Angela C.
   Barratt, Jonathan
   McCann, Gerry P.
   Burton, James O.
   Smith, Alice C.
   Graham-Brown, Matthew P. M.
TI A pilot randomised controlled trial of a structured, home-based exercise
   programme on cardiovascular structure and function in kidney transplant
   recipients: the ECSERT study design and methods
SO BMJ OPEN
LA English
DT Article
DE renal transplantation; cardiology; public health
ID PHYSICAL-ACTIVITY; BIOELECTRICAL-IMPEDANCE; RENAL-TRANSPLANTATION;
   PATIENT ACTIVATION; DISEASE; RISK; DIALYSIS; RECOMMENDATIONS;
   QUESTIONNAIRE; HYPERTROPHY
AB Background Cardiovascular disease (CVD) is a major cause of morbidity and mortality in kidney transplant recipients (KTRs). CVD risk scores underestimate risk in this population as CVD is driven by clustering of traditional and non-traditional risk factors, which lead to prognostic pathological changes in cardiovascular structure and function. While exercise may mitigate CVD in this population, evidence is limited, and physical activity levels and patient activation towards exercise and self-management are low. This pilot study will assess the feasibility of delivering a structured, home-based exercise intervention in a population of KTRs at increased cardiometabolic risk and evaluate the putative effects on cardiovascular structural and functional changes, cardiorespiratory fitness, quality of life, patient activation, healthcare utilisation and engagement with the prescribed exercise programme. Methods and analysis Fifty KTRs will be randomised 1:1 to: (1) the intervention; a 12week, home-based combined resistance and aerobic exercise intervention; or (2) the control; usual care. Intervention participants will have one introductory session for instruction and practice of the recommended exercises prior to receiving an exercise diary, dumbbells, resistance bands and access to instructional videos. The study will evaluate the feasibility of recruitment, randomisation, retention, assessment procedures and the intervention implementation. Outcomes, to be assessed prior to randomisation and postintervention, include: cardiac structure and function with stress perfusion cardiac MRI, cardiorespiratory fitness, physical function, blood biomarkers of cardiometabolic health, quality of life and patient activation. These data will be used to inform the power calculations for future definitive trials. Ethics and dissemination The protocol was reviewed and given favourable opinion by the East Midlands-Nottingham 2 Research Ethics Committee (reference: 19/EM/0209; 14 October 2019). Results will be published in peer-reviewed academic journals and will be disseminated to the patient and public community via social media, newsletter articles and presentations at conferences.
C1 [Billany, Roseanne E.; Adenwalla, Sherna F.; Robinson, Katherine A.; Brady, Emer M.; Parke, Kelly S.; Barratt, Jonathan; McCann, Gerry P.; Burton, James O.; Graham-Brown, Matthew P. M.] Univ Leicester, Dept Cardiovasc Sci, Leicester, Leics, England.
   [Billany, Roseanne E.; Adenwalla, Sherna F.; Croker, Kathryn; Barratt, Jonathan; Burton, James O.; Graham-Brown, Matthew P. M.] Univ Hosp Leicester NHS Trust, John Walls Renal Unit, Leicester, Leics, England.
   [Vadaszy, Noemi; Wilkinson, Thomas J.; Cooper, Nicola J.; Smith, Alice C.] Univ Leicester, Dept Hlth Sci, Leicester, Leics, England.
   [Bishop, Nicolette C.] Loughborough Univ, Sch Sport Exercise & Hlth Sci, Loughborough, Leics, England.
   [Wormleighton, Joanne, V; Parke, Kelly S.] Univ Hosp Leicester NHS Trust, Dept Radiol, Leicester, Leics, England.
   [Webster, Angela C.] Univ Sydney, Sch Publ Hlth, Sydney, NSW, Australia.
   [Webster, Angela C.] Westmead Hosp, Ctr Renal & Transplant Res, Westmead, NSW, Australia.
C3 University of Leicester; University Hospitals of Leicester NHS Trust;
   University of Leicester; University of Leicester; Loughborough
   University; University Hospitals of Leicester NHS Trust; University of
   Leicester; University of Sydney; NSW Health; Westmead Hospital;
   University of Sydney
RP Graham-Brown, MPM (corresponding author), Univ Leicester, Dept Cardiovasc Sci, Leicester, Leics, England.; Graham-Brown, MPM (corresponding author), Univ Hosp Leicester NHS Trust, John Walls Renal Unit, Leicester, Leics, England.
EM mgb23@leicester.ac.uk
RI Burton, James/AAQ-7361-2021; Billany, Roseanne/AAL-5520-2020; Barratt,
   Jonathan/IQV-1054-2023; Graham-Brown, Matthew/ABB-5400-2020; Adenwalla,
   Sherna/HQD-2043-2023; Webster, Angela/J-2186-2012
OI Burton, James/0000-0003-1176-7592; Cooper, Nicola/0000-0002-4486-2791;
   Adenwalla, Sherna/0000-0002-7717-8099; Barratt,
   Jonathan/0000-0002-9063-7229; McCann, Gerry/0000-0002-5542-8448; Bishop,
   Nicolette/0000-0001-6221-3907; Wilkinson, Thomas/0000-0002-7855-7752;
   Robinson, Kate A/0000-0001-9209-454X; Billany,
   Roseanne/0000-0001-9610-4717; Graham-Brown, Matthew/0000-0002-6197-180X
FU Kidney Research UK [KS_RP_003_20180913]
FX This study was funded by a project grant from Kidney Research UK (ref:
   KS_RP_003_20180913).
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NR 90
TC 5
Z9 5
U1 1
U2 8
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2044-6055
J9 BMJ OPEN
JI BMJ Open
PD OCT
PY 2021
VL 11
IS 10
AR e046945
DI 10.1136/bmjopen-2020-046945
PG 11
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA WF4IZ
UT WOS:000706271400004
PM 34610929
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Furuya, DT
   Poletto, AC
   Freitas, HS
   Machado, UF
AF Furuya, D. T.
   Poletto, A. C.
   Freitas, H. S.
   Machado, U. F.
TI Inhibition of cannabinoid CB1 receptor upregulates Slc2a4
   expression via nuclear factor-κB and sterol regulatory element-binding
   protein-1 in adipocytes
SO JOURNAL OF MOLECULAR ENDOCRINOLOGY
LA English
DT Article
ID CARDIOMETABOLIC RISK-FACTORS; GLUCOSE-TRANSPORTER GLUT-4;
   INSULIN-SENSITIVE TISSUES; WHITE ADIPOSE-TISSUE; TREATED OBESE MICE;
   GENE-EXPRESSION; ENDOCANNABINOID SYSTEM; 3T3-L1 ADIPOCYTES; OXIDATIVE
   STRESS; SOLEUS MUSCLE
AB Evidences have suggested that the endocannabinoid system is overactive in obesity, resulting in enhanced endocannabinoid levels in both circulation and visceral adipose tissue. The blockade of cannabinoid receptor type 1 (CB1) has been proposed for the treatment of obesity. Besides loss of body weight, CB1 antagonism improves insulin sensitivity, in which the glucose transporter type 4 (GLUT4) plays a key role. The aim of this study was to investigate the modulation of GLUT4-encoded gene (Slc2a4 gene) expression by CB1 receptor. For this, 3T3-L1 adipocytes were incubated in the presence of a highly selective CB1 receptor agonist (1 mu M arachidonyl-2'-chloroethylamide) and/or a CB1 receptor antagonist/inverse agonist (0.1, 0.5, or 1 mu M AM251, 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-1-piperidinyl-1H-pyrazole-3-carboxamide). After acute (2 and 4 h) and chronic (24 h) treatments, cells were harvested to evaluate: i) Slc2a4, Cnr1 (CB1 receptor-encoded gene), and Srebf1 type a (SREBP-1a type-encoded gene) mRNAs (real-time PCR); ii) GLUT4 protein (western blotting); and iii) binding activity of nuclear factor (NF)-kappa B and sterol regulatory element-binding protein (SREBP)-1 specifically in the promoter of Slc2a4 gene (electrophoretic mobility shift assay). Results revealed that both acute and chronic CB1 receptor antagonism greatly increased (similar to 2.5-fold) Slc2a4 mRNA and protein content. Additionally, CB1-induced upregulation of Slc2a4 was accompanied by decreased binding activity of NF-kappa B at 2 and 24 h, and by increased binding activity of the SREBP-1 at 24 h. In conclusion, these findings reveal that the blockade of CB1 receptor markedly increases Slc2a4/GLUT4 expression in adipocytes, a feature that involves NF-kappa B and SREBP-1 transcriptional regulation. Journal of Molecular Endocrinology (2012) 49, 97-106
C1 [Furuya, D. T.; Poletto, A. C.; Freitas, H. S.; Machado, U. F.] Univ Sao Paulo, Dept Physiol & Biophys, Inst Biomed Sci, BR-05508900 Sao Paulo, Brazil.
C3 Universidade de Sao Paulo; Institute Biomed Science, University Sao
   Paulo
RP Furuya, DT (corresponding author), Univ Sao Paulo, Dept Physiol & Biophys, Inst Biomed Sci, Ave Prof Lineu Prestes 1524, BR-05508900 Sao Paulo, Brazil.
EM danifuruya@yahoo.com
RI Machado, Ubiratan/F-3096-2017; Furuya, Daniela Tomie/E-2374-2013
OI Furuya, Daniela Tomie/0000-0002-3569-9283
FU FAPESP (Sao Paulo State Foundation for Research) [07/50554-1,
   08/09194-4]; Fundacao de Amparo a Pesquisa do Estado de Sao Paulo
   (FAPESP) [08/09194-4, 07/50554-1] Funding Source: FAPESP
FX This research did not receive any specific grant from any funding agency
   in the public, commercial or not-for-profit sector. This research was
   supported by grant from FAPESP (Sao Paulo State Foundation for Research)
   07/50554-1 and 08/09194-4.
CR Bellocchio L, 2008, J NEUROENDOCRINOL, V20, P130, DOI 10.1111/j.1365-2826.2008.01682.x
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NR 37
TC 19
Z9 21
U1 0
U2 6
PU BIOSCIENTIFICA LTD
PI BRISTOL
PA EURO HOUSE, 22 APEX COURT WOODLANDS, BRADLEY STOKE, BRISTOL BS32 4JT,
   ENGLAND
SN 0952-5041
J9 J MOL ENDOCRINOL
JI J. Mol. Endocrinol.
PD OCT
PY 2012
VL 49
IS 2
BP 97
EP 106
DI 10.1530/JME-12-0037
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 020KB
UT WOS:000309806300010
PM 22735681
OA Bronze
DA 2025-06-11
ER

PT J
AU Priedemann, E
   Kluttig, A
   Kraus, FB
   Sedding, D
   Mikolajczyk, R
   Führer, A
AF Priedemann, Eric
   Kluttig, Alexander
   Kraus, Frank Bernhard
   Sedding, Daniel
   Mikolajczyk, Rafael
   Fuehrer, Amand
TI Allostatic load and its determinants in a German sample-Results from the
   Carla cohort
SO PLOS ONE
LA English
DT Article
ID MIDLIFE WOMEN FINDINGS; SOCIOECONOMIC-STATUS; METABOLIC SYNDROME;
   PHYSICAL-ACTIVITY; CHRONIC STRESS; RISK-FACTORS; LIPID-LEVELS;
   LIFE-COURSE; HEALTH; AGE
AB Background Allostatic load (AL) is a surrogate of the physiological response to stress and reflects the 'wear and tear' on the body. Previous studies indicated that socioeconomic and behavioral determinants influence AL, which in turn is associated with health outcomes. Therefore, AL is increasingly used to operationalize the relationship between social inequality, stress, and health outcomes. This study aimed to investigate associated factors and patterns of AL in the population over a 20-year period using data from the CARLA cohort. Methods The analysis included 473 participants from the CARLA study (Cardiovascular Disease, Living and Ageing in Halle), aged 45-80 years at baseline. From recruitment in 2002 in Halle (Saale), three follow-up examinations took place until 2022. We calculated AL scores as the sum of standardized z-scores for metabolic, immune, cardiovascular, and anthropometric components. Descriptive statistics of AL scores were stratified by sex and age categories. Multiple regression analyses were conducted for the first and third follow-up to assess if there were changes in associations between sociodemographic factors and AL. Results Average AL scores of men decreased, while women's AL scores returned to baseline levels after an initial decrease observed at the first follow-up. Stratified analyses of AL scores revealed that women in the younger age cohorts had lower mean AL scores at baseline than men (women: -3.47, 95% CI [-4.24; -2.71] vs. men: -1.13, 95% CI [-1.84; -0.42] at age <55). At the same time, women showed higher mean AL scores than men in older age cohorts (women: -0.32, 95% CI [-1.58; 0.95] vs. men: -0.93, 95% CI [-1.99; 0.14] at age 65-<70). Results of multiple regression models indicated lower AL scores for women (beta: -1.21, 95% CI [-1.93, -0.49]). Professional status was associated with lower AL scores for men but not for women (beta: -1.06, 95% CI [-2.02, -0.11] for men). Further, physical activity was negatively associated with AL scores for the total study sample and for women (beta: -0.54, 95% CI [-0.82, -0.26]) for total sample and beta: -0.74, 95% CI [-1.17, -0.32] for women). Conclusion Our results highlight the importance of health awareness and physical activity for overall health, assessed by AL. Distinct AL score changes and sex-specific socioeconomic influences offer insights into sex-related patterns of aging. Further research is needed to understand the underlying mechanisms of socioeconomic influences on stress-related aging processes between sexes.
C1 [Priedemann, Eric; Kluttig, Alexander; Mikolajczyk, Rafael; Fuehrer, Amand] Martin Luther Univ Halle Wittenberg, Inst Med Epidemiol Biometr & Informat IMEBI, Med Fac, Interdisciplinary Ctr Hlth Sci, Halle, Germany.
   [Kraus, Frank Bernhard] Univ Hosp Halle, Dept Lab Med, Cent Lab, Halle, Saale, Germany.
   [Sedding, Daniel] Martin Luther Univ Halle Wittenberg, Dept Internal Med 3, Halle, Saale, Germany.
C3 Martin Luther University Halle Wittenberg; Martin Luther University
   Halle Wittenberg; Martin Luther University Halle Wittenberg
RP Priedemann, E (corresponding author), Martin Luther Univ Halle Wittenberg, Inst Med Epidemiol Biometr & Informat IMEBI, Med Fac, Interdisciplinary Ctr Hlth Sci, Halle, Germany.
EM eric.priedemann@uk-halle.de
RI Kraus, Bernhard/B-8172-2011; Führer, Amand/AAI-5939-2020
FU Open Access Publication Fund of the Martin-Luther-University
   Halle-Wittenberg
FX We are grateful to all of the participants in the CARLA-cohort, to the
   survey staff and research nurses who made this study possible. Further,
   we want to thank Alexander Kluttig and Lena Minning for the additional
   work in data preparation.
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NR 83
TC 0
Z9 0
U1 0
U2 0
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
EI 1932-6203
J9 PLOS ONE
JI PLoS One
PD APR 18
PY 2025
VL 20
IS 4
AR e0321178
DI 10.1371/journal.pone.0321178
PG 20
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 2QF5W
UT WOS:001488706300030
PM 40273157
OA gold
DA 2025-06-11
ER

PT J
AU Kobyliak, NM
   Falalyeyeva, TM
   Kuryk, OG
   Beregova, TV
   Bodnar, PM
   Zholobak, NM
   Shcherbakov, OB
   Bubnov, RV
   Spivak, MY
AF Kobyliak, Nazarii M.
   Falalyeyeva, Tetyana M.
   Kuryk, Olena G.
   Beregova, Tetyana V.
   Bodnar, Petro M.
   Zholobak, Nadiya M.
   Shcherbakov, Oleksandr B.
   Bubnov, Rostyslav V.
   Spivak, Mykola Ya
TI Antioxidative effects of cerium dioxide nanoparticles ameliorate
   age-related male infertility: optimistic results in rats and the review
   of clinical clues for integrative concept of men health and fertility
SO EPMA JOURNAL
LA English
DT Article
DE Predictive, preventive, and personalized medicine; Nanocrystalline
   cerium dioxide; Age-related male infertility; Oxidative-antioxidative
   balance; Infertility biomarkers; Seminal plasma; Ultrasound;
   Translation; Men health
ID OXIDE NANOPARTICLES; ERECTILE DYSFUNCTION; OXIDATIVE STRESS; SEMINAL
   PLASMA; PATERNAL AGE; OXIDATIVE/NITROSATIVE STRESS; METABOLIC SYNDROME;
   TESTICULAR VOLUME; HUMAN SPERMATOZOA; LIFE-STYLE
AB Background: Male infertility has largely idiopathic, multifactorial origin. Oxidative stress is a major factor that affects spermatogenesis, in particular in aging. Cerium dioxide nanoparticles (CNPs) due to their antioxidative properties are promising to impact on the development of male infertility. The aims of this study were to investigate the effects of CNPs on fertility parameters in 24-month male rats and to overview relevant literature in the field of personalized treatments, predictive diagnosis, and preventive measures for male health and fertility.
   Methods: We included 30 24-month-old male rats. After a week of adaptation to the standard diet, the rats were randomly divided into three groups with ten rats in each. Group 1 (controls) received only a standard diet. The rats of group 2 and 3 in adjunct to the standard diet during 10 days received intragastrically 10 % sodium citrate and citrate-coated CNPs in dose 1 mg/kg, respectively. We assessed sex hormones, epididymal sperm parameters and spermatogenesis, ultrasound, and morphological data of rat reproductive organs.
   Results: After a 10-day administration of CNPs, we revealed significant decrease of lipid peroxidation product levels in serum and increase of catalase and SOD activity, associated with increase of sperm count (p < 0.001) and improvement in quantitative sperm parameters (motility, viability, and percentage of spermatozoa). We found no significant changes between sperm quantitative parameters in citrate-treated rats and controls and observed age-related decrease of activated Leydig cell number and focal atrophy of the seminiferous tubules. In CNP group, we observed regeneration of seminiferous tubules, increase number and activation of Leydig cells, and 2.5-fold significant increase of serum testosterone. Ultrasound data showed the slight increase of linear measurement and volume of rat testes in CNP group. Review highlights the benefits for predictive diagnosis, preventive measures, and personalized approaches to manage male infertility in the general concept of male health also related to aging.
   Conclusion: Citrate- coated 2-5-nm CNPs lead to increase in sex hormones levels, sperm count, and quality, as well as the activation of spermatogenesis in 24-month-old male rats. Nanoceria demonstrated the perspectives to be an effective infertility treatment via reduction of oxidative stress in male reproductive organs, in particular in aging.
C1 [Kobyliak, Nazarii M.; Bodnar, Petro M.] Bogomolets Natl Med Univ, UA-01601 Kiev, Ukraine.
   [Falalyeyeva, Tetyana M.; Beregova, Tetyana V.] Taras Shevchenko Natl Univ Kyiv, UA-01601 Kiev, Ukraine.
   [Kuryk, Olena G.] State Sci Enterprise Sci Pract Ctr Prophylact & C, State Management Affairs Dept, UA-01014 Kiev, Ukraine.
   [Zholobak, Nadiya M.; Shcherbakov, Oleksandr B.; Bubnov, Rostyslav V.; Spivak, Mykola Ya] Natl Acad Sci Ukraine, Zabolotny Inst Microbiol & Virol, Zabolotny Str 154, UA-03680 Kiev, Ukraine.
   [Spivak, Mykola Ya] LCL DIAPROF, UA-04123 Kiev, Ukraine.
   [Bubnov, Rostyslav V.] Clin Hosp Pheophania, State Management Affairs Dept, UA-03680 Kiev, Ukraine.
C3 Bogomolets National Medical University; Ministry of Education & Science
   of Ukraine; Taras Shevchenko National University of Kyiv; National
   Academy of Sciences Ukraine; Zabolotny Institute of Microbiology &
   Virology of NASU; Feofaniya Clinical Hospital
RP Bubnov, RV (corresponding author), Natl Acad Sci Ukraine, Zabolotny Inst Microbiol & Virol, Zabolotny Str 154, UA-03680 Kiev, Ukraine.
EM rostbubnov@gmail.com
RI Falalyeyeva, Tetyana/Z-3076-2019; Beregova, Tetyana/P-9379-2018;
   Falalyeyeva, Tetyana/AEY-9788-2022; Shcherbakov, Alexander
   B/N-1569-2018; Bubnov, Rostyslav/E-8395-2013; Kuryk, Olena/N-8928-2018;
   Kobyliak, Nazarii/R-8703-2016; Zholobak, Nadiia M./I-3158-2019
OI Falalyeyeva, Tetyana/0000-0002-4415-9676; Shcherbakov, Alexander
   B/0000-0002-0020-0913; Bubnov, Rostyslav/0000-0003-3148-9884; Spivak,
   Mykola/0000-0002-9148-990X; Kuryk, Olena/0000-0003-3093-4325; Beregova,
   Tetyana/0009-0001-9976-1891; Kobyliak, Nazarii/0000-0001-9814-689X;
   Spivak, Mykola/0000-0002-4394-7275; Zholobak, Nadiia
   M./0000-0003-2792-9787
FU State Agency on Science, Innovations and Informatisation of Ukraine
FX The study was conducted with the support of the State Agency on Science,
   Innovations and Informatisation of Ukraine. We acknowledge the The EPMA
   Journal editorial team and BioMed Central team for the opportunity to
   publish this work.
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NR 140
TC 53
Z9 54
U1 0
U2 15
PU SPRINGER INTERNATIONAL PUBLISHING AG
PI CHAM
PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND
SN 1878-5077
EI 1878-5085
J9 EPMA J
JI EPMA J.
PD JUN 10
PY 2015
VL 6
AR 12
DI 10.1186/s13167-015-0034-2
PG 22
WC Medicine, General & Internal; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Research & Experimental Medicine
GA CU6KV
UT WOS:000363641800001
PM 26097523
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU AlBadri, A
   Leong, D
   Merz, CNB
   Wei, J
   Handberg, EM
   Shufelt, CL
   Mehta, PK
   Nelson, MD
   Thomson, LE
   Berman, DS
   Shaw, LJ
   Cook-Wiens, G
   Pepine, CJ
AF AlBadri, Ahmed
   Leong, Derek
   Merz, C. Noel Bairey
   Wei, Janet
   Handberg, Eileen M.
   Shufelt, Chrisandra L.
   Mehta, Puja K.
   Nelson, Michael D.
   Thomson, Louise E.
   Berman, Daniel S.
   Shaw, Leslee J.
   Cook-Wiens, Galen
   Pepine, Carl J.
TI Typical angina is associated with greater coronary endothelial
   dysfunction but not abnormal vasodilatory reserve
SO CLINICAL CARDIOLOGY
LA English
DT Article
DE Typical Angina; Atypical Angina; Coronary Microvascular Dysfunction;
   Coronary Endothelial Dysfunction; Quality of Life
ID ARTERY-DISEASE; CHEST-PAIN; MYOCARDIAL-INFARCTION; MICROVASCULAR
   DYSFUNCTION; SYNDROME-X; WOMEN; PECTORIS; PREVALENCE; FLOW;
   PATHOPHYSIOLOGY
AB BackgroundTypical angina (TA) is defined as substernal chest pain precipitated by physical exertion or emotional stress and relieved with rest or nitroglycerin. Women and elderly patients are usually have atypical symptoms both at rest and during stress, often in the setting of nonobstructive coronary artery disease (CAD).
   HypothesisTo further understand this, we performed subgroup analysis comparing subjects who presented with TA vs nontypical angina (NTA) using baseline data of patients with nonobstructive CAD and coronary microvascular dysfunction (CMD) enrolled in a clinical trial.
   Methods155 subjects from the RWISE study were divided into 2 groups based on angina characteristics: TA (defined as above) and NTA (angina that does not meet criteria for TA). Coronary reactivity testing (responses to adenosine, acetylcholine, and nitroglycerin), cardiac magnetic resonance-determined myocardial perfusion reserve index (MPRI), baseline Seattle Angina Questionnaire (SAQ), and Duke Activity Status Index (DASI) scores were evaluated.
   ResultsThe mean age was 55 10 years; Overall, 30% of subjects had TA. Baseline shortness of breath, invasively assessed acetylcholine-mediated coronary endothelial function, and SAQ score were worse in the TA group (all P < 0.05), whereas adenosine-mediated coronary flow reserve, MPRI, and DASI score were similar to the NTA group.
   ConclusionsAmong subjects with CMD and no obstructive CAD, those with TA had more angina pectoris, shortness of breath, and worse quality of life, as well as more severe coronary endothelial dysfunction. Typical angina in the setting of CMD is associated with worse symptom burden and coronary endothelial dysfunction. These results indicate that TA CMD subjects represent a relatively new CAD phenotype for future study and treatment trials.
C1 [AlBadri, Ahmed; Leong, Derek; Merz, C. Noel Bairey; Wei, Janet; Shufelt, Chrisandra L.; Nelson, Michael D.] Cedars Sinai Heart Inst, Barbra Streisand Womens Heart Ctr, Los Angeles, CA USA.
   [Handberg, Eileen M.; Pepine, Carl J.] Univ Florida, Div Cardiol, Gainesville, FL USA.
   [Mehta, Puja K.; Shaw, Leslee J.] Emory Univ, Program Cardiovasc Outcomes Res & Epidemiol, Atlanta, GA 30322 USA.
   [Thomson, Louise E.; Berman, Daniel S.] Cedars Sinai Med Ctr, S Mark Taper Fdn Imaging Ctr, Los Angeles, CA 90048 USA.
   [Cook-Wiens, Galen] Cedars Sinai Med Ctr, Biostat & Bioinformat Res Ctr, Los Angeles, CA 90048 USA.
C3 Cedars Sinai Medical Center; State University System of Florida;
   University of Florida; Emory University; Cedars Sinai Medical Center;
   Cedars Sinai Medical Center
RP Merz, CNB (corresponding author), 127 S San Vicente Blvd,Suite A3600, Los Angeles, CA 90048 USA.
EM Noel.BaireyMerz@cshs.org
RI berman, daniel/ABF-0670-2022; Shaw, Leslee/ABG-4621-2022
OI mehta, Puja/0000-0001-9459-9306; Handberg, Eileen/0000-0002-7805-9577;
   Bairey Merz, C. Noel/0000-0002-9933-5155; Nelson,
   Michael/0000-0002-3232-8639; Shufelt, Chrisandra/0000-0001-6886-9210;
   AlBadri, Ahmed/0000-0003-0011-0827; Pepine, Carl/0000-0002-6011-681X
FU Gilead; National Institutes of Health (NIH) National Heart, Lung, and
   Blood Institute (NHLBI) [N01-HV-68161, N01-HV-68162, N01-HV-68163,
   N01-HV-68164]; General Clinical Research Centers (GCRC) from the
   National Center for Research Resources (NCRR) [MO1-RR00425];
   NIH/National Center for Advancing Translational Sciences (NCATS)
   [UL1RR033176]; UCLA Clinical and Translational Science Institute (CTSI)
   [UL1TR000124]; University of Florida CTSI [UL1TR001427]; NIH [R01
   HL089765]; Gustavus and Louis Pfeiffer Research Foundation, Denville,
   New Jersey; Women's Guild of Cedars-Sinai Medical Center, Los Angeles,
   California; Edythe L. Broad Women's Heart Research Fellowship,
   Cedars-Sinai Medical Center, Los Angeles, California; Constance Austin
   Women's Heart Research Fellowship; Barbra Streisand Women's
   Cardiovascular Research and Education Program; Cedars-Sinai Medical
   Center, Los Angeles, California; Erika Glazer Women's Heart Health
   Project, Cedars-Sinai Medical Center, Los Angeles, California; Barbra
   Streisand Women's Heart Center, Los Angeles, California
FX This work was supported by an unrestricted research grant from Gilead
   and by contracts from the National Institutes of Health (NIH) National
   Heart, Lung, and Blood Institute (NHLBI), nos. N01-HV-68161,
   N01-HV-68162, N01-HV-68163, and N01-HV-68164; General Clinical Research
   Centers (GCRC) grant MO1-RR00425 from the National Center for Research
   Resources (NCRR); grant UL1RR033176 from the NIH/National Center for
   Advancing Translational Sciences (NCATS); UCLA Clinical and
   Translational Science Institute (CTSI) grant UL1TR000124 and University
   of Florida CTSI grant UL1TR001427; NIH research grant R01 HL089765; and
   grants from the following: the Gustavus and Louis Pfeiffer Research
   Foundation, Denville, New Jersey; the Women's Guild of Cedars-Sinai
   Medical Center, Los Angeles, California; the Edythe L. Broad Women's
   Heart Research Fellowship, Cedars-Sinai Medical Center, Los Angeles,
   California; the Constance Austin Women's Heart Research Fellowship, the
   Barbra Streisand Women's Cardiovascular Research and Education Program,
   Cedars-Sinai Medical Center, Los Angeles, California; and the Erika
   Glazer Women's Heart Health Project, Cedars-Sinai Medical Center, Los
   Angeles, California. Funding to pay the Open Access publication charges
   for this article was provided by the Barbra Streisand Women's Heart
   Center, Los Angeles, California.
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NR 39
TC 5
Z9 7
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0160-9289
EI 1932-8737
J9 CLIN CARDIOL
JI Clin. Cardiol.
PD OCT
PY 2017
VL 40
IS 10
BP 886
EP 891
DI 10.1002/clc.22740
PG 6
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA FM3NH
UT WOS:000414912700015
PM 28605043
OA Green Published, hybrid, Green Accepted
DA 2025-06-11
ER

PT J
AU Johnson, BD
   Shaw, LJ
   Buchthal, SD
   Merz, CNB
   Kim, HW
   Scott, KN
   Doyle, M
   Olson, MB
   Pepine, CJ
   den Hollander, J
   Sharaf, B
   Rogers, WJ
   Mankad, S
   Forder, JR
   Kelsey, SF
   Pohost, GM
AF Johnson, BD
   Shaw, LJ
   Buchthal, SD
   Merz, CNB
   Kim, HW
   Scott, KN
   Doyle, M
   Olson, MB
   Pepine, CJ
   den Hollander, J
   Sharaf, B
   Rogers, WJ
   Mankad, S
   Forder, JR
   Kelsey, SF
   Pohost, GM
TI Prognosis in women with myocardial ischemia in the absence of
   obstructive coronary disease - Results from the National Institutes of
   Health-National Heart, Lung, and Blood Institute-sponsored Women's
   Ischemia Syndrome Evaluation (WISE)
SO CIRCULATION
LA English
DT Article
DE prognosis; women; cost-benefit analysis; magnetic resonance imaging;
   spectroscopy
ID MAGNETIC-RESONANCE-SPECTROSCOPY; CHEST-PAIN; GENDER-DIFFERENCES;
   NMR-SPECTROSCOPY; ARTERY-DISEASE; SYNDROME-X; ANGINA; P-31; MEN;
   ECHOCARDIOGRAPHY
AB Background - We previously reported that 20% of women with chest pain but without obstructive coronary artery disease ( CAD) had stress-induced reduction in myocardial phosphocreatine - adenosine triphosphate ratio by phosphorus-31 nuclear magnetic resonance spectroscopy ( abnormal MRS), consistent with myocardial ischemia. The prognostic implications of these findings are unknown.
   Methods and Results - Women referred for coronary angiography for suspected myocardial ischemia underwent MRS handgrip stress testing and follow-up evaluation. These included ( 1) n = 60 with no CAD/normal MRS, (2) n = 14 with no CAD/ abnormal MRS, and ( 3) n = 352 a reference group with CAD. Cardiovascular events were death, myocardial infarction, heart failure, stroke, other vascular events, and hospitalization for unstable angina. Cumulative freedom from events at 3 years was 87%, 57%, and 52% for women with no CAD/ normal MRS, no CAD/ abnormal MRS, and CAD, respectively ( P < 0.01). After adjusting for CAD and cardiac risk factors, a phosphocreatine - adenosine triphosphate ratio decrease of 1% increased the risk of a cardiovascular event by 4% ( P = 0.02). The higher event rate in women with no CAD/ abnormal MRS was primarily due to hospitalization for unstable angina, which is associated with repeat catheterization and higher healthcare costs.
   Conclusions - Among women without CAD, abnormal MRS consistent with myocardial ischemia predicted cardiovascular outcome, notably higher rates of anginal hospitalization, repeat catheterization, and greater treatment costs. Further evaluation into the underlying pathophysiology and possible treatment options for women with evidence of myocardial ischemia but without CAD is indicated.
C1 Univ Pittsburgh, Grad Sch Publ Hlth, Pittsburgh, PA USA.
   Atlanta Cardiovasc Res Inst, Atlanta, GA USA.
   Univ Alabama, Ctr Nucl Imaging Res, Birmingham, AL USA.
   Cedars Sinai Med Ctr, Womens Hlth Program, Los Angeles, CA USA.
   Univ Florida, Gainesville, FL USA.
   Vet Affairs Med Ctr, Gainesville, FL 32608 USA.
   Rhode Isl Hosp, Providence, RI USA.
   Univ Alabama, Med Ctr, Birmingham, AL 35294 USA.
   Western Penn Allegheny Hosp, Pittsburgh, PA USA.
   Univ So Calif, Div Cardiovasc Med, Keck Sch Med, Los Angeles, CA 90089 USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE); University
   of Pittsburgh; University of Alabama System; University of Alabama
   Birmingham; Cedars Sinai Medical Center; State University System of
   Florida; University of Florida; US Department of Veterans Affairs;
   Veterans Health Administration (VHA); Lifespan Health Rhode Island;
   Rhode Island Hospital; University of Alabama System; University of
   Alabama Birmingham; University of Southern California
RP Univ So Calif, Div Cardiovasc Med, Keck Sch Med, 1355 San Pablo St,AHC 117, Los Angeles, CA 90089 USA.
EM Pohost@usc.edu
RI Shaw, Leslee/ABG-4621-2022
FU NHLBI NIH HHS [R01-HL-073412-01, N01-HV-68164, U01 HL649141, U01
   HL649241, N01-HV-68163, N01-HV-68162, N01-HV-68161] Funding Source:
   Medline; PHS HHS [U0164829] Funding Source: Medline
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NR 27
TC 326
Z9 341
U1 0
U2 9
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0009-7322
EI 1524-4539
J9 CIRCULATION
JI Circulation
PD JUN 22
PY 2004
VL 109
IS 24
BP 2993
EP 2999
DI 10.1161/01.CIR.0000130642.79868.B2
PG 7
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 831FH
UT WOS:000222178800015
PM 15197152
DA 2025-06-11
ER

PT J
AU Scalone, G
   De Caterina, A
   Leone, AM
   Tritarelli, A
   Mollo, R
   Pinnacchio, G
   D'Amario, D
   Lanza, GA
   Crea, F
AF Scalone, Giancarla
   De Caterina, Alberto
   Leone, Antonio Maria
   Tritarelli, Alessandra
   Mollo, Roberto
   Pinnacchio, Gaetano
   D'Amario, Domenico
   Lanza, Gaetano Antonio
   Crea, Filippo
TI Effect of Exercise on Circulating Endothelial Progenitor Cells in
   Microvascular Angina
SO CIRCULATION JOURNAL
LA English
DT Article
DE Endothelial progenitor cells; Exercise stress test; Microvascular
   angina; Platelet reactivity
ID CORONARY-ARTERY-DISEASE; TRAINING INCREASES; SYNDROME-X; DYSFUNCTION;
   PECTORIS; MOBILIZATION; ISCHEMIA; NUMBER
AB Background: Circulating endothelial progenitor cells (EPCs) might limit endothelial dysfunction in patients with microvascular angina (MVA). Endothelial colony-forming cells (ECFCs; displaying the CD34+/KDR+/CD45- phenotype) are currently regarded as true EPCs. The aim of this study was to evaluate exercise-induced ECFC mobilization and platelet reactivity in patients with MVA or with obstructive coronary artery disease (CAD).
   Methods and Results: Exercise stress test (EST) was performed in 20 MVA patients, 20 CAD patients and 20 controls. Platelet reactivity was assessed before and after EST as formation of monocyte-platelet aggregates (MPAs) and CD41 platelet expression, without and with adenosine diphosphate (ADP) stimulation. ECFC number was measured before and 24 h after EST. At rest, MPAs and CD41 platelet expression increased more with ADP in MVA patients (+71 +/- 11.0% and +37 +/- 7.5%, respectively), than in CAD patients (+37 +/- 8.6% and +19 +/- 4.5%, respectively) and controls (+29 +/- 3.5% and +21 +/- 3.1%, respectively; P<0.001 for both). At rest, ECFCs tended to be lower in CAD patients, compared to MVA patients and controls (4.1 +/- 5.0%, 7.2 +/- 6.0% and 7.3 +/- 7.0% cells/10(5), respectively; P=0.056). After EST, ECFCs increased less in MVA patients (+2.8 +/- 11) compared to CAD patients (+3.3 +/- 15; P<0.05) and controls (+7.4 +/- 24; P<0.01).
   Conclusions: In MVA patients, EST is able to blunt the peculiar increase of platelet reactivity to ADP present at rest; in contrast, no potential protective response of ECFCs to exercise was seen in these patients.
C1 [Scalone, Giancarla; De Caterina, Alberto; Leone, Antonio Maria; Tritarelli, Alessandra; Mollo, Roberto; Pinnacchio, Gaetano; D'Amario, Domenico; Lanza, Gaetano Antonio; Crea, Filippo] Univ Cattolica Sacro Cuore, Dept Cardiovasc Med, I-00168 Rome, Italy.
C3 Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli
RP Lanza, GA (corresponding author), Univ Cattolica Sacro Cuore, Ist Cardiol, Largo A Gemelli 8, I-00168 Rome, Italy.
EM g.a.lanza@rm.unicatt.it
RI Lanza, Gaetano/AAC-2660-2019; Crea, Filippo/AAC-9754-2022; Leone,
   Antonio/AAC-4124-2020; D'Amario, Domenico/L-3603-2018
OI Pinnacchio, Gaetano/0000-0001-6642-1682; Leone, Antonio
   Maria/0000-0002-1276-9883; /0000-0003-3774-8330
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NR 40
TC 14
Z9 16
U1 0
U2 2
PU JAPANESE CIRCULATION SOC
PI TOYKO
PA 18TH FLOOR IMPERIAL HOTEL TOWER, 1-1-1 UCHISAIWAI-CHO CHIYODA-KU, TOYKO,
   100-0011, JAPAN
SN 1346-9843
EI 1347-4820
J9 CIRC J
JI Circ. J.
PD JUL
PY 2013
VL 77
IS 7
BP 1777
EP 1782
DI 10.1253/circj.CJ-12-0996
PG 6
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 177WB
UT WOS:000321405000021
PM 23558828
OA gold
DA 2025-06-11
ER

PT J
AU Wang, HH
   Chowdhury, KK
   Lautt, WW
AF Wang, Hui Helen
   Chowdhury, Kawshik K.
   Lautt, W. Wayne
TI A Synergistic, Balanced Antioxidant Cocktail, Protects Aging Rats from
   Insulin Resistance and Absence of Meal-Induced Insulin Sensitization
   (AMIS) Syndrome
SO MOLECULES
LA English
DT Review
DE HISS-dependent insulin resistance (HDIR); Meal-induced Insulin
   Sensitization (MIS); Absence of Meal-induced Insulin Sensitization
   (AMIS); Hepatic Insulin Sensitizing Substance (HISS);
   S-adenosylmethionine; vitamins E and C (SAMEC)
ID NITRIC-OXIDE; SYNDROME-X; OXIDATIVE STRESS; AGED RATS; SENSITIVITY;
   HISS; GLUTATHIONE; EXERCISE; SUCROSE; THIOACETAMIDE
AB A series of in vivo and in vitro studies using animal and human models in the past 15 years have demonstrated that approximately 55% (similar to 66% in humans) of the glucose disposal effect of an i.v. injection of insulin in the fed state is dependent on the action of a second hormone, hepatic insulin sensitizing substance (HISS), which is released from the liver and stimulates glucose uptake in muscle, heart and kidneys. Sensitization of the insulin response by a meal through release of HISS is called meal-induced insulin sensitization (MIS). Absence of HISS action results in postprandial hyperglycemia, hyperinsulinemia, hyperlipidemia, adiposity, increased free radical stress and a cluster of progressive metabolic and cardiovascular dysfunctions referred to as the AMIS (absence of meal-induced insulin sensitization) syndrome. Reduced HISS release accounts for the insulin resistance that occurs with aging and is made worse by physical inactivity and diets high in sucrose or fat. This brief review provides an update of major metabolic disturbances associated with aging due to reduction of HISS release, and the protection against these pathological changes in aging animals using a balanced synergistic antioxidant cocktail SAMEC (S-adenosylmethionine, vitamins E and C). The synergy amongst the components is consistent with the known benefits of antioxidants supplied by a mixed diet and acting through diverse mechanisms. Using only three constituents, SAMEC appears suitable as an antioxidant specifically targeting the AMIS syndrome.
C1 [Wang, Hui Helen; Chowdhury, Kawshik K.; Lautt, W. Wayne] Univ Manitoba, Dept Pharmacol & Therapeut, Coll Med, Fac Hlth Sci, Winnipeg, MB R3E 0T6, Canada.
C3 University of Manitoba
RP Wang, HH (corresponding author), Univ Manitoba, Dept Pharmacol & Therapeut, Coll Med, Fac Hlth Sci, A224-753 McDermot Ave, Winnipeg, MB R3E 0T6, Canada.
EM h.helen.wang@med.umanitoba.ca; kawshik88@yahoo.com;
   wlautt@cc.umanitoba.ca
RI Lautt, W./AAC-6106-2021
OI Lautt, W. Wayne/0000-0002-7239-1798
FU Canadian Institutes of Health Research; Canadian Diabetes Foundation;
   DiaMedica; SciMar Ltd. (Dauphin, MB, Canada)
FX We thank the Canadian Institutes of Health Research, the Canadian
   Diabetes Foundation, DiaMedica and SciMar Ltd. (Dauphin, MB, Canada) for
   funding the insulin resistance and AMIS research in aging animals, and
   antioxidant protection studies presented in this review.
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NR 69
TC 2
Z9 3
U1 0
U2 9
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1420-3049
J9 MOLECULES
JI Molecules
PD JAN
PY 2015
VL 20
IS 1
BP 669
EP 682
DI 10.3390/molecules20010669
PG 14
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA AZ6HB
UT WOS:000348319000040
PM 25569521
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Singleton, JM
   Garland, T
AF Singleton, Jennifer M.
   Garland, Theodore, Jr.
TI Influence of corticosterone on growth, home-cage activity, wheel
   running, and aerobic capacity in house mice selectively bred for high
   voluntary wheel-running behavior
SO PHYSIOLOGY & BEHAVIOR
LA English
DT Article
DE Artificial selection; Body composition; Exercise; Food consumption;
   Growth; Locomotion
ID DEPRESSION-LIKE BEHAVIOR; SPONTANEOUS PHYSICAL-ACTIVITY; MAXIMAL
   OXYGEN-CONSUMPTION; BASE-LINE; ARTIFICIAL SELECTION; CUSHINGS-SYNDROME;
   ENDURANCE CAPACITY; METABOLIC SYNDROME; IMMUNE FUNCTION; ORGAN MASSES
AB Glucocorticoids, a class of metabolic hormones, impact a wide range of traits (e.g., behavior, skeletal growth, muscle maintenance, glucose metabolism), and variation in concentrations of circulating glucocorticoids (such as corticosterone), at the level of natural individual variation, in relation to endocrine disorders, or from exogenous supplementation, have manifold effects. Changes in circulating corticosterone concentrations can also impact multiple aspects of locomotor behavior, including both motivation and physical ability for exercise. To examine further the role of corticosterone in locomotor behavior and associated traits, we utilized laboratory house mice from a long-term experiment that selectively breeds for high levels of voluntary exercise. As compared with four non-selected control (C) lines, mice from the four replicate High Runner (HR) lines have similar to 2-fold higher baseline circulating corticosterone concentrations as well as similar to 3-fold higher voluntary wheel running on a daily basis, higher home-cage activity when deprived of wheels, higher maximal aerobic capacity, and smaller body size; potentially, all of these differences could be modulated by circulating corticosterone. We administered 50 mu g/mL corticosterone-21-hemisuccinate in the drinking water of both HR and C male mice from weaning through similar to 8 weeks of age. As compared with mice from C lines, HR mice had higher endogenous corticosterone levels; higher daily wheel-running distance, duration, and speed; higher maximal oxygen consumption during forced exercise (VO(2)max); spent more time in the closed arms of an elevated plus maze; and had larger reproductive fat pads. For both HR and C mice, corticosterone treatment strongly suppressed endogenous circulating corticosterone levels, decreased growth rate and adult body mass, increased food and water consumption (both adjusted for body mass), increased entries into closed arms of an elevated plus maze, decreased home-cage activity (total and average intensity), decreased wheel-running distance and maximum speed, and decreased VO(2)max. At the suborganismal level, corticosterone treatment decreased relative adrenal, liver, and triceps surae muscle mass, as well as tail length, but increased both subdermal and reproductive fat pad masses, as well as hematocrit. Overall, the responses of both HR and C mice to corticosterone supplementation were "negative" from a health perspective. These results have significant implications for understanding both the evolution of baseline corticosterone levels and stress-related effects on activity levels. They also suggest that patients experiencing extended periods of glucocorticoid treatment might benefit from attempts to increase their physical activity as an adjuvant.
C1 [Singleton, Jennifer M.; Garland, Theodore, Jr.] Univ Calif Riverside, Dept Evolut Ecol & Organismal Biol, Riverside, CA 92521 USA.
C3 University of California System; University of California Riverside
RP Garland, T (corresponding author), Univ Calif Riverside, Dept Evolut Ecol & Organismal Biol, Riverside, CA 92521 USA.
EM tgarland@ucr.edu
OI Garland, Theodore/0000-0002-7916-3552
FU US NSF [IOS-11212732, DEB-1655362]
FX We thank Wendy Saltzman for her assistance in designing experiments and
   for comments on the manuscript. Alberto Castro and Jessica Malisch also
   commented on the manuscript. Laurie Graham constructed the home-cage
   sensor system. Mark A. Chappell wrote the custom software for home-cage
   activity monitoring and assisted with measurement of VO<INF>2</INF>max.
   Ring T. Carde provided access to the video tracking software, and James
   Colbath helped process the EPM videos. Wendy Acosta and Russel Hart
   provided assistance with the corticosterone assays. Other members of the
   Garland lab helped with producing the mice, including Gerald Claghorn,
   Zoe Thompson, Jarren Kay, and Layla Hiramatsu. Supported by US NSF
   grants IOS-11212732 and DEB-1655362 to T.G.
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NR 130
TC 24
Z9 32
U1 0
U2 19
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0031-9384
J9 PHYSIOL BEHAV
JI Physiol. Behav.
PD JAN 1
PY 2019
VL 198
BP 27
EP 41
DI 10.1016/j.physbeh.2018.10.001
PG 15
WC Psychology, Biological; Behavioral Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Behavioral Sciences
GA HD5IS
UT WOS:000452563000004
PM 30292826
DA 2025-06-11
ER

PT J
AU Chuang, HC
   Lin, HY
   Liao, PL
   Huang, CC
   Lin, LL
   Hsu, WM
   Chuang, JH
AF Chuang, Hui-Ching
   Lin, Hung-Yu
   Liao, Pei-Lin
   Huang, Chao-Cheng
   Lin, Li-Ling
   Hsu, Wen-Ming
   Chuang, Jiin-Haur
TI Immunomodulator polyinosinic-polycytidylic acid enhances the inhibitory
   effect of 13-cis-retinoic acid on neuroblastoma through a
   TLR3-related immunogenic-apoptotic response
SO LABORATORY INVESTIGATION
LA English
DT Article
ID HIGH-RISK NEUROBLASTOMA; 13-CIS RETINOIC ACID; IMMUNOLOGICAL ASPECTS;
   RANDOMIZED-TRIAL; DIFFERENTIATION; EXPRESSION; CHILDREN; THERAPY; CELLS;
   BETA
AB The authors show that 13-cis-retinoic acid (13cRA) has an antiproliferative effect in MYCN-amplified neuroblastoma cells. Poly (I:C) synergized with 13cRA enhances anti-apoptotic effects through innate immune signaling and mitochondrial stress response in 13cRA-responsive neuroblastoma cells. In addition, a combination of 13cRA/poly (I:C) induces neural differentiation and inhibits vessel formation, leading to retarded tumor growth.
   High-risk neuroblastoma is associated with low long-term survival rates due to recurrence or metastasis. Retinoids, including 13-cis-retinoic acid (13cRA), are commonly used for the treatment of high-risk neuroblastoma after myeloablative therapy; however, there are significant side effects and resistance rates. In this study, we demonstrated that 13cRA has a better antiproliferative effect in MYCN-amplified neuroblastoma cells than in MYCN-nonamplified neuroblastoma cells. In MYCN-amplified SK-N-DZ cells, 13cRA induced significant upregulation of toll-like receptor 3 (TLR3) and mitochondrial antiviral-signaling protein (MAVS) expression in a time-dependent manner. Furthermore, poly (I:C), a synthetic agonist of TLR3, effectively synergized with 13cRA to enhance antiproliferative effects through upregulation of the innate immune signaling and the mitochondrial stress response, leading to augmentation of the apoptotic response in 13cRA-responsive cancer cells. In addition, the 13cRA/poly (I:C) combination induced neural differentiation through activation of retinoic acid receptors beta (RAR-beta), restoring expression of alpha-thalassemia/mental retardation syndrome X-linked (ATRX) protein, and inhibiting vessel formation, leading to retarded tumor growth in a mouse xenograft model. These results suggest that the combination of poly (I:C) and RA may provide synergistic therapeutic benefits for treatment of patients with high-risk neuroblastoma.
C1 [Chuang, Hui-Ching] Kaohsiung Chang Gung Mem Hosp, Dept Otolaryngol, Kaohsiung, Taiwan.
   [Chuang, Hui-Ching; Lin, Hung-Yu; Liao, Pei-Lin; Huang, Chao-Cheng; Chuang, Jiin-Haur] Chang Gung Univ, Coll Med, Kaohsiung, Taiwan.
   [Chuang, Hui-Ching; Lin, Hung-Yu; Liao, Pei-Lin; Chuang, Jiin-Haur] Kaohsiung Chang Gung Mem Hosp, Mitochondrial Res Unit, Kaohsiung, Taiwan.
   [Lin, Hung-Yu; Liao, Pei-Lin; Chuang, Jiin-Haur] Kaohsiung Chang Gung Mem Hosp, Dept Pediat Surg, Kaohsiung, Taiwan.
   [Huang, Chao-Cheng] Kaohsiung Chang Gung Mem Hosp, Dept Pathol, Kaohsiung, Taiwan.
   [Lin, Li-Ling] Univ Texas Hlth Sci Ctr San Antonio, Dept Mol Med, San Antonio, TX 78229 USA.
   [Hsu, Wen-Ming] Natl Taiwan Univ, Natl Taiwan Univ Hosp, Coll Med, Dept Surg, Taipei, Taiwan.
C3 Chang Gung Memorial Hospital; Chang Gung University; Chang Gung Memorial
   Hospital; Chang Gung Memorial Hospital; Chang Gung Memorial Hospital;
   University of Texas System; University of Texas Health Science Center at
   San Antonio; National Taiwan University; National Taiwan University
   Hospital
RP Chuang, JH (corresponding author), Kaohsiung Chang Gung Mem Hosp, Mitochondrial Res Unit, Kaohsiung, Taiwan.; Chuang, JH (corresponding author), Kaohsiung Chang Gung Mem Hosp, Dept Pediat Surg, Kaohsiung, Taiwan.
EM jhchuang@cgmh.org.tw
RI Tsai, Ming/ABA-9806-2020
OI Lin, Hung-Yu/0000-0002-9035-5408; HSU, WEN-MING/0000-0002-5145-9538;
   Lin, Li-Ling/0000-0001-9891-5900
FU Chang Gung Memorial Hospital (CGMH) [CMRPG8F0311-3] Funding Source:
   Medline
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NR 44
TC 19
Z9 20
U1 1
U2 9
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 0023-6837
EI 1530-0307
J9 LAB INVEST
JI Lab. Invest.
PD APR
PY 2020
VL 100
IS 4
BP 606
EP 618
DI 10.1038/s41374-019-0356-0
PG 13
WC Medicine, Research & Experimental; Pathology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pathology
GA KX2SU
UT WOS:000521732000008
PM 31857701
OA Bronze
DA 2025-06-11
ER

PT J
AU Cai, XT
   Zhang, Q
   Wang, JW
   Miao, YY
   Sun, YQ
   Xia, ZY
   Zhang, LY
   Yu, QW
   Jiang, ZZ
AF Cai, Xiaotong
   Zhang, Qin
   Wang, Jiwei
   Miao, Yingying
   Sun, Yuqing
   Xia, Ziyin
   Zhang, Luyong
   Yu, Qinwei
   Jiang, Zhenzhou
TI Novel Dual PPAR δ/γ Partial Agonist Induces Hepatic Lipid Accumulation
   through Direct Binding and Inhibition of AKT1 Phosphorylation, Mediating
   CD36 Upregulation
SO CHEMICAL RESEARCH IN TOXICOLOGY
LA English
DT Article
ID PI3K/AKT SIGNALING PATHWAY; OXIDATIVE STRESS; TARGETS
AB ZLY06 is a dual agonist of peroxisome proliferator-activated receptor (PPAR) delta/gamma, showing potential therapeutic effects on metabolic syndrome. However, our research has revealed that ZLY06 exhibits hepatotoxicity in normal C57BL/6J mice, though the precise mechanism remains unclear. This study aims to investigate the manifestations and mechanisms of ZLY06-induced hepatotoxicity. We administered ZLY06 via oral gavage to C57BL/6J mice (once daily for six weeks) and monitored various indicators to preliminarily explore its hepatotoxicity. Additionally, we further investigate the specific mechanisms of ZLY06-induced hepatotoxicity using PPAR inhibitors (GW9662 and GSK0660) and the Protein kinase B (AKT) activator (SC79). Results showed that ZLY06 led to increased serum ALP, ALT and AST, as well as elevated liver index and hepatic lipid levels. There was upregulation in the gene and protein expression of lipid metabolism-related molecules Acc, Scd1, Cd36, Fabp1 and Fabp2 in hepatocytes, with Cd36 showing the most significant change. Furthermore, cotreatment with SC79 significantly reduced ZLY06-induced hepatotoxicity in AML12 cells, evidenced by decreased intracellular TG levels and downregulation of CD36 expression. Specific knockdown of CD36 also mitigated ZLY06-induced hepatotoxicity. The study found that ZLY06 may bind to AKT1, inhibiting its phosphorylation activation, with the downregulation of p-AKT1 preceding the upregulation of CD36. In summary, ZLY06 mediates the upregulation of CD36 by potentially binding to and inhibiting the phosphorylation of AKT1, leading to hepatic lipid metabolism disorder and inducing liver toxicity.
C1 [Cai, Xiaotong; Zhang, Qin; Wang, Jiwei; Miao, Yingying; Sun, Yuqing; Xia, Ziyin; Zhang, Luyong; Yu, Qinwei; Jiang, Zhenzhou] China Pharmaceut Univ, New Drug Screening & Pharmacodynam Evaluat Ctr, State Key Lab Nat Med, Nanjing 210009, Peoples R China.
   [Jiang, Zhenzhou] China Pharmaceut Univ, Jiangsu Ctr Pharmacodynam Res & Evaluat, Key Lab Drug Qual Control & Pharmacovigilance, Minist Educ, Nanjing 210009, Peoples R China.
   [Zhang, Luyong] Guangdong Pharmaceut Univ, Ctr Drug Res & Dev, Guangzhou 510006, Peoples R China.
C3 China Pharmaceutical University; Ministry of Education - China; China
   Pharmaceutical University; Guangdong Pharmaceutical University
RP Zhang, LY; Yu, QW; Jiang, ZZ (corresponding author), China Pharmaceut Univ, New Drug Screening & Pharmacodynam Evaluat Ctr, State Key Lab Nat Med, Nanjing 210009, Peoples R China.; Jiang, ZZ (corresponding author), China Pharmaceut Univ, Jiangsu Ctr Pharmacodynam Res & Evaluat, Key Lab Drug Qual Control & Pharmacovigilance, Minist Educ, Nanjing 210009, Peoples R China.; Zhang, LY (corresponding author), Guangdong Pharmaceut Univ, Ctr Drug Res & Dev, Guangzhou 510006, Peoples R China.
EM lyzhang@cpu.edu.cn; yuqinwei7213@cpu.edu.cn; beaglejiang@cpu.edu.cn
RI Sun, Yuqing/IVH-6857-2023; ZHAO, Xingyu/JNR-1669-2023; Zhang,
   Yubing/JAC-9437-2023
OI Wang, Jiwei/0009-0009-8791-6735
FU National Natural Science Foundation of China [82304642, 81773827];
   Natural Science Foundation of Jiangsu Province [BK20210430]; China
   Postdoctoral Science Foundation [2020M681786]; Double First-Class"
   University project [CPU2018GY33]
FX The work was supported by the National Natural Science Foundation of
   China (82304642 to Q.Y., 81773827 to Z.J.), the Natural Science
   Foundation of Jiangsu Province (BK20210430 to Q.Y.), China Postdoctoral
   Science Foundation(2020M681786 to Q.Y.), "Double First-Class" University
   project (CPU2018GY33 to Z.J.).
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NR 38
TC 0
Z9 0
U1 3
U2 5
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0893-228X
EI 1520-5010
J9 CHEM RES TOXICOL
JI Chem. Res. Toxicol.
PD SEP 5
PY 2024
VL 37
IS 9
BP 1574
EP 1587
DI 10.1021/acs.chemrestox.4c00268
EA SEP 2024
PG 14
WC Chemistry, Medicinal; Chemistry, Multidisciplinary; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Chemistry; Toxicology
GA G0M3V
UT WOS:001307744800001
PM 39235066
DA 2025-06-11
ER

PT J
AU Brady, MB
   O'Brien, EC
   Geraghty, AA
   Courtney, AU
   Kilbane, MT
   Twomey, PJ
   McKenna, MJ
   Crowley, RK
   McAuliffe, FM
AF Brady, Michelle B.
   O'Brien, Eileen C.
   Geraghty, Aisling A.
   Courtney, Amanda U.
   Kilbane, Mark T.
   Twomey, Patrick J.
   McKenna, Malachi J.
   Crowley, Rachel K.
   McAuliffe, Fionnuala M.
TI Blood pressure in pregnancy-A stress test for hypertension? Five-year,
   prospective, follow-up of the ROLO study
SO CLINICAL ENDOCRINOLOGY
LA English
DT Article
DE cardiovascular disease; hypertension; maternal hypertension; metabolic
   syndrome; pregnancy
ID CARDIOVASCULAR-DISEASE; LATER LIFE; RISK; PREVENTION; GUIDELINE
AB Objective To investigate whether maternal blood pressure (BP) below the diagnostic criteria of hypertensive disorders of pregnancy (HDP) is associated with maternal BP 5 years later. Design Prospective, observational study. Setting Dublin, Ireland (2007-2011). Sample Three hundred twenty-nine women from the ROLO study (Randomized cOntrol trial of LOw glycaemic index diet to prevent the recurrence of macrosomia). Methods Maternal BP measurements were taken during pregnancy (13, 28 and 34 weeks' gestation and day 1 postpartum) and at the 5-year follow-up. Systolic BP (SBP) and diastolic BP (DBP) were categorized as normal (SBP < 120 and DBP < 80 mm Hg), elevated (SBP 120-129 and DBP < 80 mm Hg), HTN stage 1 (SBP 130-139 or DBP 80-89 mm Hg) or HTN stage 2 (SBP >= 140 or DBP >= 90 mm Hg) at each timepoint. Main Outcome Measures Maternal blood pressure at the 5-year follow-up. Results Women with elevated BP at 28 and 34 weeks' gestation had 2.68 (95% CI: 1.36-5.26) and 2.45-fold (95% CI: 1.22-4.95) increased odds of HTN stage 1 respectively, at the 5-year follow-up, compared to those with normal BP in pregnancy. Conclusion Elevated BP at 28 and 34 weeks' gestation was associated with an increased risk of HTN stage 1 at 5 years later. Thus, raised BP, below the diagnostic criteria of HDP, could be flagged for follow-up postpartum.
C1 [Brady, Michelle B.; O'Brien, Eileen C.; Geraghty, Aisling A.; Courtney, Amanda U.; McKenna, Malachi J.; McAuliffe, Fionnuala M.] Univ Coll Dublin, Sch Med, Natl Matern Hosp, UCD Perinatal Res Ctr, Dublin, Ireland.
   [Kilbane, Mark T.] St Vincents Univ Hosp, Dept Clin Chem, Dublin, Ireland.
   [Twomey, Patrick J.] St Vincents Univ Hosp, Clin Chem, Dublin, Ireland.
   [Twomey, Patrick J.] Univ Coll Dublin, Sch Med, Dublin, Ireland.
   [McKenna, Malachi J.; Crowley, Rachel K.] St Vincents Univ Hosp, Dept Endocrinol, Dublin, Ireland.
   [Crowley, Rachel K.] Univ Coll Dublin, Dublin, Ireland.
C3 National Maternity Hospital, Dublin; University College Dublin;
   University College Dublin; Saint Vincent's University Hospital;
   University College Dublin; Saint Vincent's University Hospital;
   University College Dublin; University College Dublin; Saint Vincent's
   University Hospital; University College Dublin
RP McAuliffe, FM (corresponding author), Univ Coll Dublin, Sch Med, Natl Matern Hosp, UCD Perinatal Res Ctr, Dublin, Ireland.
EM fionnuala.mcauliffe@ucd.ie
RI Twomey, Patrick/AAN-7614-2021
OI O'Brien, Eileen/0000-0001-6187-4017; Geraghty,
   Aisling/0000-0003-0861-7630; Kilbane, Mark/0000-0002-8516-0956;
   mcauliffe, fionnuala/0000-0002-3477-6494; Crowley,
   Rachel/0000-0003-1472-4117
FU Health Research Board, Health Research Centre for Health and Diet
   Research, Ireland; National Maternity Hospital Medical Fund; European
   Union [289346]
FX The ROLO study and follow-up were funded by the Health Research Board,
   Health Research Centre for Health and Diet Research, Ireland, the
   National Maternity Hospital Medical Fund and the European Union's
   Seventh Framework Programme (FP7/2007-2013), Project Early Nutrition
   under grant agreement number 289346.
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NR 26
TC 4
Z9 4
U1 0
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0300-0664
EI 1365-2265
J9 CLIN ENDOCRINOL
JI Clin. Endocrinol.
PD DEC
PY 2019
VL 91
IS 6
BP 816
EP 823
DI 10.1111/cen.14102
EA OCT 2019
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA JN4JQ
UT WOS:000492278000001
PM 31556131
OA Green Published
DA 2025-06-11
ER

PT J
AU Mozos, I
   Malainer, C
   Horbanczuk, J
   Gug, C
   Stoian, D
   Luca, CT
   Atanasov, AG
AF Mozos, Ioana
   Malainer, Clemens
   Horbanczuk, Jaroslaw
   Gug, Cristina
   Stoian, Dana
   Luca, Constantin Tudor
   Atanasov, Atanas G.
TI Inflammatory Markers for Arterial Stiffness in Cardiovascular Diseases
SO FRONTIERS IN IMMUNOLOGY
LA English
DT Review
DE inflammatory markers; arterial stiffness; inflammation; cardiovascular
   diseases; cardiovascular risk factors
ID C-REACTIVE PROTEIN; PULSE-WAVE VELOCITY; VASCULAR ADHESION PROTEIN-1;
   NEUTROPHIL-LYMPHOCYTE RATIO; INTIMA-MEDIA THICKNESS;
   CORONARY-HEART-DISEASE; CHRONIC KIDNEY-DISEASE; NEUTROPHIL/LYMPHOCYTE
   RATIO; ENDOTHELIAL FUNCTION; PERIODONTAL-DISEASE
AB Arterial stiffness predicts an increased risk of cardiovascular events. Inflammation plays a major role in large arteries stiffening, related to atherosclerosis, arteriosclerosis, endothelial dysfunction, smooth muscle cell migration, vascular calcification, increased activity of metalloproteinases, extracellular matrix degradation, oxidative stress, elastolysis, and degradation of collagen. The present paper reviews main mechanisms explaining the crosstalk between inflammation and arterial stiffness and the most common inflammatory markers associated with increased arterial stiffness, considering the most recent clinical and experimental studies. Diverse studies revealed significant correlations between the severity of arterial stiffness and inflammatory markers, such as white blood cell count, neutrophil/lymphocyte ratio, adhesion molecules, fibrinogen, C-reactive protein, cytokines, microRNAs, and cyclooxygenase-2, in patients with a broad variety of diseases, such as metabolic syndrome, diabetes, coronary heart disease, peripheral arterial disease, malignant and rheumatic disorders, polycystic kidney disease, renal transplant, familial Mediterranean fever, and oral infections, and in women with preeclampsia or after menopause. There is strong evidence that inflammation plays an important and, at least, partly reversible role in the development of arterial stiffness, and inflammatory markers may be useful additional tools in the assessment of the cardiovascular risk in clinical practice. Combined assessment of arterial stiffness and inflammatory markers may improve non-invasive assessment of cardiovascular risk, enabling selection of high-risk patients for prophylactic treatment or more regular medical examination. Development of future destiffening therapies may target pro-inflammatory mechanisms.
C1 [Mozos, Ioana] Victor Babes Univ Med & Pharm, Dept Funct Sci, Timisoara, Romania.
   [Mozos, Ioana] Victor Babes Univ Med & Pharm, Ctr Translat Res & Syst Med, Timisoara, Romania.
   [Horbanczuk, Jaroslaw; Atanasov, Atanas G.] Polish Acad Sci, Inst Genet & Anim Breeding, Jastrzebiec, Poland.
   [Gug, Cristina] Victor Babes Univ Med & Pharm, Dept Microscop Morphol, Timisoara, Romania.
   [Stoian, Dana] Victor Babes Univ Med & Pharm, Dept Internal Med 2, Timisoara, Romania.
   [Luca, Constantin Tudor] Victor Babes Univ Med & Pharm, Dept Cardiol, Timisoara, Romania.
   [Atanasov, Atanas G.] Univ Vienna, Fac Life Sci, Dept Pharmacognosy, Vienna, Austria.
   [Atanasov, Atanas G.] Med Univ Vienna, Ctr Physiol & Pharmacol, Dept Vasc Biol & Thrombosis Res, Vienna, Austria.
C3 Victor Babes University of Medicine & Pharmacy, Timisoara; Victor Babes
   University of Medicine & Pharmacy, Timisoara; Polish Academy of
   Sciences; Institute of Genetics & Animal Biotechnology, Polish Academy
   of Sciences; Victor Babes University of Medicine & Pharmacy, Timisoara;
   Victor Babes University of Medicine & Pharmacy, Timisoara; Victor Babes
   University of Medicine & Pharmacy, Timisoara; University of Vienna;
   Medical University of Vienna
RP Mozos, I (corresponding author), Victor Babes Univ Med & Pharm, Dept Funct Sci, Timisoara, Romania.; Mozos, I (corresponding author), Victor Babes Univ Med & Pharm, Ctr Translat Res & Syst Med, Timisoara, Romania.; Atanasov, AG (corresponding author), Polish Acad Sci, Inst Genet & Anim Breeding, Jastrzebiec, Poland.; Atanasov, AG (corresponding author), Univ Vienna, Fac Life Sci, Dept Pharmacognosy, Vienna, Austria.; Atanasov, AG (corresponding author), Med Univ Vienna, Ctr Physiol & Pharmacol, Dept Vasc Biol & Thrombosis Res, Vienna, Austria.
EM ioana_mozos@yahoo.com; a.atanasov.mailbox@gmail.com
RI Atanasov, Atanas/C-5535-2013; Horbanczuk, Jaroslaw/ABD-8389-2021; Luca,
   Constantin/LVS-4258-2024; Stoian, Dana/W-4777-2019; Mozos,
   Ioana/AAB-4874-2020; Gug, Cristina/ABF-4924-2020; Stefanadis,
   Christodoulos/ABH-2232-2020
OI Mozos, Ioana/0000-0001-6353-7698; Gug, Cristina/0000-0003-0111-6606;
   Stefanadis, Christodoulos/0000-0001-5974-6454; STOIAN,
   DANA/0000-0002-0926-9511
FU Polish KNOW (Leading National Research Centre) Scientific Consortium
   "Healthy Animal-Safe Food" [05-1/KNOW2/2015]
FX The authors acknowledge the support by the Polish KNOW (Leading National
   Research Centre) Scientific Consortium "Healthy Animal-Safe Food,"
   decision of Ministry of Science and Higher Education No.
   05-1/KNOW2/2015.
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NR 161
TC 260
Z9 283
U1 1
U2 67
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-3224
J9 FRONT IMMUNOL
JI Front. Immunol.
PD AUG 31
PY 2017
VL 8
AR 1058
DI 10.3389/fimmu.2017.01058
PG 16
WC Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology
GA FF5RM
UT WOS:000409051300001
PM 28912780
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Park, JK
   Kim, JY
   Moon, JY
   Ahn, EY
   Lee, EY
   Lee, EB
   Cho, KH
   Song, YW
AF Park, Jin Kyun
   Kim, Jae-Yong
   Moon, Jin Young
   Ahn, Eun Young
   Lee, Eun Young
   Lee, Eun Bong
   Cho, Kyung-Hyun
   Song, Yeong Wook
TI Altered lipoproteins in patients with systemic lupus erythematosus are
   associated with augmented oxidative stress: a potential role in
   atherosclerosis
SO ARTHRITIS RESEARCH & THERAPY
LA English
DT Article
DE Atherosclerosis; Oxidation; Lipoproteins; LDL; Systemic lupus
   erythematosus
ID HIGH-DENSITY-LIPOPROTEIN; CORONARY-HEART-DISEASE; RISK-FACTORS;
   ACCELERATED ATHEROSCLEROSIS; CARDIOVASCULAR-DISEASE;
   MYOCARDIAL-INFARCTION; METABOLIC SYNDROME; INHIBITS 3; WOMEN; PREVALENCE
AB Background: To examine the structural and oxidative properties of lipoproteins from patients with systemic lupus erythematosus (SLE).
   Methods: The lipid profiles of 35 SLE patients and 15 healthy controls (HCs) were compared. Oxidation status, susceptibility to oxidation, and structural integrity of low-density lipoprotein (LDL) were determined by measuring malondialdehyde (MDA), de novo formation of conjugated dienes in the presence of CuSO4, and mobility on gel electrophoresis, respectively. In vitro foam cell formation and the oxidative potential in zebrafish embryos were examined.
   Results: LDL levels in SLE patients and HCs were similar (p = 0.277). LDL from SLE patients was more fragmented than that from HCs. In addition, LDL from SLE patients was more oxidized than LDL from HCs (p < 0.001) and more susceptible to de novo oxidation (p < 0.001) in vitro. THP-1 cells engulfed more LDL from SLE patients than LDL from HCs (p < 0.001). LDL from SLE patients, which was injected into zebrafish embryos, induced a higher degree of oxidation and a higher mortality than LDL from HCs (both p < 0.001). The survival of embryos treated with oxidized LDL was significantly better in the presence of HDL3 from HCs than that from SLE patients (all p < 0.001).
   Conclusions: Lipoproteins from SLE patients exhibited greater oxidative potential, which might contribute to accelerated atherosclerosis in SLE.
C1 [Park, Jin Kyun; Song, Yeong Wook] Seoul Natl Univ, Grad Sch Convergence Sci & Technol, Dept Mol Med & Biopharmaceut Sci, Seoul, South Korea.
   [Park, Jin Kyun; Song, Yeong Wook] Seoul Natl Univ, Coll Med, Med Res Ctr, Seoul, South Korea.
   [Park, Jin Kyun; Moon, Jin Young; Ahn, Eun Young; Lee, Eun Young; Lee, Eun Bong; Song, Yeong Wook] Seoul Natl Univ Hosp, Div Rheumatol, Dept Internal Med, Seoul, South Korea.
   [Kim, Jae-Yong; Cho, Kyung-Hyun] Yeungnam Univ, Dept Med Biotechnol, Gyeongsangbuk Do, South Korea.
   [Song, Yeong Wook] Seoul Natl Univ, Coll Med, Dept Internal Med, Div Rheumatol, 101 Daehak Ro, Seoul 03080, South Korea.
C3 Seoul National University (SNU); Seoul National University (SNU); Seoul
   National University (SNU); Seoul National University Hospital; Yeungnam
   University; Seoul National University (SNU)
RP Song, YW (corresponding author), Seoul Natl Univ, Grad Sch Convergence Sci & Technol, Dept Mol Med & Biopharmaceut Sci, Seoul, South Korea.; Song, YW (corresponding author), Seoul Natl Univ, Coll Med, Med Res Ctr, Seoul, South Korea.; Song, YW (corresponding author), Seoul Natl Univ Hosp, Div Rheumatol, Dept Internal Med, Seoul, South Korea.; Song, YW (corresponding author), Seoul Natl Univ, Coll Med, Dept Internal Med, Div Rheumatol, 101 Daehak Ro, Seoul 03080, South Korea.
EM ysong@snu.ac.kr
RI Lee, Eun/J-5594-2012; Park, Kyung Woo/AAX-3046-2020; Lee,
   Youngil/AAX-2787-2021
OI Lee, Eun Young/0000-0001-6975-8627; Park, Jin Kyun/0000-0003-2167-9393
FU Korea Health Technology R&D Project through Korea Health Industry
   Development Institute - Ministry of Health and Welfare, Republic of
   Korea [HI13C1754]; Mid-carrier Researcher Program through National
   Research Foundation - Ministry of Science, ICT, and Future Planning,
   Republic of Korea [2014-11049455]
FX This work was supported by a grant from the Korea Health Technology R&D
   Project through the Korea Health Industry Development Institute funded
   by the Ministry of Health and Welfare, Republic of Korea (grant number:
   HI13C1754) and by a grant from the Mid-carrier Researcher Program
   (2014-11049455) through the National Research Foundation funded by the
   Ministry of Science, ICT, and Future Planning, Republic of Korea.
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NR 46
TC 29
Z9 29
U1 0
U2 14
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1478-6354
EI 1478-6362
J9 ARTHRITIS RES THER
JI Arthritis Res. Ther.
PD DEC 30
PY 2016
VL 18
AR 306
DI 10.1186/s13075-016-1204-x
PG 9
WC Rheumatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Rheumatology
GA EG5EU
UT WOS:000391067100002
PM 28038677
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Vázquez-Velasco, M
   González-Torres, L
   López-Gasco, P
   Bastida, S
   Benedí, J
   González-Muñoz, MJ
   Sánchez-Muniz, FJ
AF Vazquez-Velasco, Miguel
   Gonzalez-Torres, Laura
   Lopez-Gasco, Patricia
   Bastida, Sara
   Benedi, Juana
   Jose Gonzalez-Munoz, Maria
   Sanchez-Muniz, Francisco J.
TI Effects of glucomannan/spirulina-surimi on liver oxidation and
   inflammation in Zucker rats fed atherogenic diets
SO JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
LA English
DT Article
DE Squid-surimi; Glucomannan; Spirulina; Hypercholesterolemia;
   Antioxidants; Inflammation
ID NITRIC-OXIDE; GLUTATHIONE STATUS; CHOLESTEROL; EXPRESSION; OBESITY;
   STRESS; FIBER; FAT
AB Cholesterolemia is associated with pro-oxidative and proinflammatory effects. Glucomannan- or glucomannan plus spirulina-enriched surimis were included in cholesterol-enriched high-saturated diets to test the effects on lipemia; antioxidant status (glutathione status, and antioxidant enzymatic levels, expressions and activities); and inflammation biomarkers (endothelial nitric oxide synthase (eNOS), inducible nitric oxide synthase (iNOS), tumor necrosis factor alpha (TNF-alpha)) in Zucker fa/fa rats. Groups of eight rats each received diet containing squid-surimi (C), squid-surimi cholesterol-enriched diet (HC), glucomannan-squid-surimi cholesterol-enriched diet (HG), or glucomannan-spirulina-squid-surimi cholesterol-enriched diet (HGS) over a period of 7 weeks. HC diet induced severe hyperlipemia, hepatomegalia, increased inflammation markers, and impaired antioxidant status significantly (at least p < 0.05) vs. C diet. HG diet decreased lipemia and liver size and normalized antioxidant status to C group levels, but increased TNF-alpha with respect to HC diet (p < 0.05). In general terms, 3 g/kg of spirulina in diet maintained the positive results observed in the HG diet but, in addition, increased inflammation index [eNOS/(eNOS + iNOS)] and decreased plasma TNF-alpha (both p < 0.05). In conclusion, glucomannan plus a small amount of spirulina blocks negative effects promoted by hypercholesterolemic diets. Although more studies are needed, present results suggest the utility of including glucomannan and/or spirulina as functional ingredients into fish derivates to be consumed by people on metabolic syndrome risk.
C1 [Vazquez-Velasco, Miguel; Gonzalez-Torres, Laura; Bastida, Sara; Sanchez-Muniz, Francisco J.] Univ Complutense Madrid, Fac Farm, Dept Nutr & Bromatol Nutr 1, E-28040 Madrid, Spain.
   [Lopez-Gasco, Patricia; Benedi, Juana] Univ Complutense Madrid, Fac Farm, Dept Farmacol, E-28040 Madrid, Spain.
   [Jose Gonzalez-Munoz, Maria] Univ Alcala de Henares, Fac Farm, Dept Nutr Bromatol & Toxicol, Alcala De Henares 28871, Spain.
C3 Complutense University of Madrid; Complutense University of Madrid;
   Universidad de Alcala
RP Sánchez-Muniz, FJ (corresponding author), Univ Complutense Madrid, Fac Farm, Dept Nutr & Bromatol Nutr 1, Plaza Ramon y Cajal S-N, E-28040 Madrid, Spain.
EM frasan@ucm.es
RI Sanchez-Muniz, Francisco/K-9795-2014; GonzálezTorres,
   Laura/AAE-6577-2019; Bastida, Sara/L-1619-2014; Velasco,
   M./AAA-9858-2019
OI Gonzalez Torres, Laura/0000-0002-8641-2166; Vazquez-Velasco,
   Miguel/0000-0002-4168-2234; GonzalezTorres, Laura/0000-0002-1589-2190
FU Spanish projects [AGL-2011-29644-C02-02, AGL-2008-04892-C03-02];
   Consolider-Ingenio project [CSD2007-00016]; Consejo Nacional de Ciencia
   y Tecnologia (CONACYT) of Mexico
FX The present study was supported by the Spanish projects
   AGL-2011-29644-C02-02, AGL-2008-04892-C03-02 and Consolider-Ingenio 2010
   project # CSD2007-00016. We gratefully acknowledge the foreign
   fellowship for graduate studies granted by the Consejo Nacional de
   Ciencia y Tecnologia (CONACYT) of Mexico to Laura Gonzalez-Torres.
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NR 35
TC 14
Z9 14
U1 0
U2 21
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1138-7548
EI 1877-8755
J9 J PHYSIOL BIOCHEM
JI J. Physiol. Biochem.
PD DEC
PY 2015
VL 71
IS 4
BP 611
EP 622
DI 10.1007/s13105-015-0425-9
PG 12
WC Biochemistry & Molecular Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Physiology
GA CX6NU
UT WOS:000365818600002
PM 26239810
DA 2025-06-11
ER

PT J
AU Omote, Y
   Deguchi, K
   Kurata, T
   Yamashita, T
   Sato, K
   Hishikawa, N
   Abe, K
AF Omote, Yoshio
   Deguchi, Kentaro
   Kurata, Tomoko
   Yamashita, Toru
   Sato, Kota
   Hishikawa, Nozomi
   Abe, Koji
TI Telmisartan Promotes Potential Glucose Homeostasis in Stroke-Resistant
   Spontaneously Hypertensive Rats via Peroxisome Proliferator-Activated
   Receptor γ Activation
SO CURRENT NEUROVASCULAR RESEARCH
LA English
DT Article
DE Telmisartan; SHR-SR; AT1R; PPAR-gamma; insulin receptor 3
ID OXIDATIVE STRESS; BLOOD-PRESSURE; ALZHEIMERS-DISEASE; INSULIN;
   INFLAMMATION; HIPPOCAMPUS; DEMENTIA; AGONISTS; MICE
AB An angiotensin 2 type 1 receptor blocker (ARB) telmisartan possesses not only an antihypertensive effect but also an anti-metabolic syndrome effect due to peroxisome proliferator-activated receptor gamma (PPAR-gamma) activation. In the present study, we examined the effects of telmisartan on the angiotensin 2 type 1 receptor (AT1R), PPAR-gamma, and insulin receptor (IR) in stroke-resistant spontaneously hypertensive rats (SHR-SR), comparing them with Wistar rats. Three-months-old SHR-SR rats were divided into three treatment groups, i.e., vehicle (SHR/Ve), low-dose telmisartan (0.3 mg/kg/day, SHR/Low), and high-dose telmisartan (3 mg/kg/day, SHR/High). Compared with Wistar rats, SHR/Ve increased the staining of AT1R, PPAR-gamma and IR in the cerebral cortical neurons. On the other hand, telmisartan dose-dependently suppressed the excessive expression of AT1R and IR, but enhanced PPAR-gamma activation. Low-dose telmisartan showed these effects even without lowering blood pressure (BP), while high-dose telmisartan lowered BP and showed further effects. The present study suggests that even a low dose of telmisartan decreased AT1R and IR, and increased PPAR-gamma in the cerebral cortex of SHR-SR without lowering BP, probably by improving glucose homeostasis. The high dose of telmisartan showed further decreases in AT1R and IR, and further PPAR-gamma activation while lowering BP, suggesting an additive benefit to lowering BP, namely the improvement of glucose homeostasis.
C1 [Omote, Yoshio; Deguchi, Kentaro; Kurata, Tomoko; Yamashita, Toru; Sato, Kota; Hishikawa, Nozomi; Abe, Koji] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Neurol, Okayama 7008558, Japan.
C3 Okayama University
RP Abe, K (corresponding author), Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Neurol, 2-5-1 Shikatacho, Okayama 7008558, Japan.
EM degu@cc.okayama-u.ac.jp
OI Yamashita, Toru/0000-0003-3634-5679
FU Ministry of Education, Culture, Sports, Science and Technology of Japan
   [21390267]; Research Committee of CNS Degenerative Diseases; Ministry of
   Health, Labour and Welfare of Japan
FX This work was partly supported by a Grant-in-Aid for Scientific Research
   (B) 21390267 and the Ministry of Education, Culture, Sports, Science and
   Technology of Japan, and by Grants-in-Aid from the Research Committee of
   CNS Degenerative Diseases (I. Nakano) and grants (H. Mizusawa, M.
   Nishizawa, H. Sasaki, G. Sobue) from the Ministry of Health, Labour and
   Welfare of Japan.
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NR 20
TC 5
Z9 5
U1 0
U2 2
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1567-2026
EI 1875-5739
J9 CURR NEUROVASC RES
JI Curr. Neurovasc. Res.
PY 2015
VL 12
IS 1
BP 91
EP 97
DI 10.2174/1567202612666150104150310
PG 7
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA CB5OS
UT WOS:000349677900012
PM 25557372
DA 2025-06-11
ER

PT J
AU Tveden-Nyborg, P
   Lykkesfeldt, J
AF Tveden-Nyborg, Pernille
   Lykkesfeldt, Jens
TI Does Vitamin C Deficiency Increase Lifestyle-Associated Vascular Disease
   Progression? Evidence Based on Experimental and Clinical Studies
SO ANTIOXIDANTS & REDOX SIGNALING
LA English
DT Review
ID NITRIC-OXIDE SYNTHASE; FATTY LIVER-DISEASE; LOW-DENSITY-LIPOPROTEIN; 3RD
   NATIONAL-HEALTH; ENVIRONMENTAL TOBACCO-SMOKE; INCREASED OXIDATIVE
   STRESS; SERUM ASCORBIC-ACID; KAPPA-B ACTIVATION; ENDOTHELIAL
   DYSFUNCTION; METABOLIC SYNDROME
AB Significance: Despite continuous advances in the prevention of cardiovascular disease (CVD), critical issues associated with an unhealthy lifestyle remain an increasing cause of morbidity and mortality in industrialized countries. Recent Advances: A growing body of literature supports a specific role for vitamin C in a number of reactions that are associated with vascular function and control including, for example, nitric oxide bioavailability, lipid metabolism, and vascular integrity. Critical Issues: A large body of epidemiological evidence supports a relationship between poor vitamin C status and increased risk of developing CVD, and the prevalence of deficiency continues to be around 10%-20% of the general Western population although this problem could easily and cheaply be solved by supplementation. However, large intervention studies using vitamin C have not found a beneficial effect of supplementation. This review outlines the proposed mechanism by which vitamin C deficiency worsens CVD progression. In addition, it discusses problems with the currently available literature, including the discrepancies between the large intervention studies and the experimental and epidemiological literature. Future Directions: Increased insights into vitamin C deficiency-mediated CVD progression will enable the design of future randomized controlled trials that are better suited to test the efficacy of vitamin C in disease prevention as well as the identification of high-risk individuals which could possibly benefit from supplementation. Antioxid. Redox Signal. 19, 2084-2104.
C1 [Tveden-Nyborg, Pernille; Lykkesfeldt, Jens] Univ Copenhagen, Fac Hlth & Med Sci, Dept Vet Dis Biol, DK-1870 Frederiksberg C, Denmark.
C3 University of Copenhagen
RP Lykkesfeldt, J (corresponding author), Univ Copenhagen, Fac Hlth & Med Sci, Dept Vet Dis Biol, 9 Ridebanevej, DK-1870 Frederiksberg C, Denmark.
EM jopl@sund.ku.dk
RI Lykkesfeldt, Jens/A-1072-2011
OI Lykkesfeldt, Jens/0000-0002-6514-8407; Tveden-Nyborg,
   Pernille/0000-0002-5574-5742
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NR 206
TC 40
Z9 41
U1 0
U2 21
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1523-0864
EI 1557-7716
J9 ANTIOXID REDOX SIGN
JI Antioxid. Redox Signal.
PD DEC 10
PY 2013
VL 19
IS 17
BP 2084
EP 2104
DI 10.1089/ars.2013.5382
PG 21
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 273SQ
UT WOS:000328557000008
PM 23642093
DA 2025-06-11
ER

PT J
AU Dylag, KA
   Wieczorek-Stawinska, W
   Burkot, K
   Drzewiecki, L
   Przybyszewska, K
   Tokarz, A
   Dumnicka, P
AF Dylag, Katarzyna Anna
   Wieczorek-Stawinska, Wiktoria
   Burkot, Katarzyna
   Drzewiecki, Lukasz
   Przybyszewska, Katarzyna
   Tokarz, Aleksandra
   Dumnicka, Paulina
TI Exploring Nutritional Status and Metabolic Imbalances in Children with
   FASD: A Cross-Sectional Study
SO NUTRIENTS
LA English
DT Article
DE foetal alcohol spectrum disorder; FASD; prenatal alcohol exposure; PAE;
   malnutrition; macronutrient; micronutrient; nutrimetabolomics;
   paediatric
ID PRENATAL ALCOHOL EXPOSURE; PEDIATRIC REFERENCE INTERVALS; BETA-CAROTENE
   PROTECT; VITAMIN-E; BIOCHEMICAL MARKERS; SPECTRUM DISORDERS; CALIPER
   COHORT; ETHANOL; BODY; ALBUMIN
AB Background/Objectives: Malnutrition is a significant concern in paediatric populations, particularly among children with neurodevelopmental disorders such as foetal alcohol spectrum disorder (FASD). This study aimed to examine macronutrient and micronutrient imbalances and assess the nutritional status of a group of patients with FASD. Methods: This study involved an analysis of the serum levels of key nutrients in a group of children diagnosed with FASD. Macronutrients and micronutrients were measured to identify any imbalances, including vitamin D, B12, E, A, albumin, and serum protein, among others. Results: The study found a high prevalence of vitamin D deficiency among the patients. Additionally, elevated serum concentrations of micronutrients such as vitamin B12, E, and A were observed in 8%, 7%, and 19% of patients, respectively. Macronutrient imbalances were noted, including high levels of albumin and serum protein, indicating a possible metabolic disturbance. Unexpectedly, high rates of hypercholesterolemia were observed, raising concerns about an increased risk of metabolic syndrome in this population. Conclusions: These findings suggest that the principal issue among patients with FASD is an altered metabolism rather than nutritional deficiencies. Potential causes of these abnormalities could include oxidative stress and changes in body composition. The results underline the need for further research to better understand the unique nutritional challenges in children with FASD and to guide the development of targeted therapeutic strategies.
C1 [Dylag, Katarzyna Anna] Jagiellonian Univ Med Coll, Dept Pathophysiol, PL-31121 Krakow, Poland.
   [Dylag, Katarzyna Anna; Wieczorek-Stawinska, Wiktoria; Burkot, Katarzyna; Drzewiecki, Lukasz; Przybyszewska, Katarzyna; Tokarz, Aleksandra] St Louis Children Hosp, PL-31503 Krakow, Poland.
   [Dumnicka, Paulina] Jagiellonian Univ Med Coll, Chair Med Biochem, PL-31034 Krakow, Poland.
C3 Jagiellonian University; Collegium Medicum Jagiellonian University;
   Jagiellonian University; Collegium Medicum Jagiellonian University
RP Dylag, KA (corresponding author), Jagiellonian Univ Med Coll, Dept Pathophysiol, PL-31121 Krakow, Poland.; Dylag, KA (corresponding author), St Louis Children Hosp, PL-31503 Krakow, Poland.
EM katarzyna.anna.dylag@uj.edu.pl; a.tokarz@dzieciecyszpital.pl
RI Dylag, Katarzyna/AFV-2888-2022; Dylag, Katarzyna Anna/P-3261-2015
OI Dylag, Katarzyna Anna/0000-0001-6886-0136; Wieczorek-Stawinska,
   Wiktoria/0000-0001-5771-7334; Dumnicka, Paulina/0000-0003-3667-857X
FU National Agency for Prevention of Addictions; 
   [2358/13/11/2.1.2/H/DBMWM/2022]
FX This research was funded by the National Agency for Prevention of
   Addictions, grant number 2358/13/11/2.1.2/H/DBMWM/2022.
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NR 85
TC 1
Z9 1
U1 0
U2 0
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD OCT
PY 2024
VL 16
IS 19
AR 3401
DI 10.3390/nu16193401
PG 16
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA I7P5E
UT WOS:001332141300001
PM 39408368
OA gold
DA 2025-06-11
ER

PT J
AU Kabeer, SW
   Pant, R
   Sharma, S
   Tikoo, K
AF Kabeer, Shaheen Wasil
   Pant, Rajat
   Sharma, Shivam
   Tikoo, Kulbhushan
TI Laccaic acid restores epigenetic alterations responsible for high fat
   diet induced insulin resistance in C57BL/6J mice
SO CHEMICO-BIOLOGICAL INTERACTIONS
LA English
DT Article
DE Insulin resistance; Epigenetics; Laccaic acid; FOXO1; Histone
   modifications
ID METABOLIC SYNDROME; IN-VITRO; INFLAMMATION; DISEASE; STRESS; FOXO
AB Laccaic acid, the major constituent of the food colouring agent-lac dye, possesses antioxidant and anti-inflammatory properties. Here we have evaluated the effects of laccaic acid on the high-fat diet induced insu-lin resistance in C57BL/6J mice. Insulin resistance was developed in mice by feeding high-fat diet for 12 weeks. 6 week treatment with laccaic acid showed significant improvement in the morphometric, biochemical parameters and liver function. Western blotting experiments showed, laccaic acid increased phosphorylation of IRS1/2/ AKT/GSK3 beta which is suppressed under insulin-resistant conditions in liver. Furthermore, it also attenuated the inflammatory ERK/NF kappa B signalling, thereby reducing the expression of inflammatory cytokines-TNF alpha, IL-1 beta and IL-6. Concomitantly, laccaic acid increased AMPK/AKT-mediated phosphorylation of FOXO1, preventing its nuclear translocation and transcriptional activation of gluconeogenic genes (G6PC and PCK1). Interestingly, treatment with laccaic acid also prevented high-fat diet induced alterations of histone methylation (H3K27me3 and H3K36me2) at global level. Our chromatin-immunoprecipitation data shows high-fat diet induced loss of inactivation mark H3K27me3 at FOXO1 promoter was regained upon laccaic acid treatment. Additionally, the expression of the H3K27 methylating enzyme EZH2 was also upregulated by laccaic acid. Together it all results in the downregulation of FOXO1 gene expression. To the best of our knowledge, we provide first evidence that laccaic acid either directly or indirectly modulates the epigenetic landscape of genes responsible for high-fat diet induced insulin resistance.
C1 [Kabeer, Shaheen Wasil; Pant, Rajat; Sharma, Shivam; Tikoo, Kulbhushan] Natl Inst Pharmaceut Educ & Res, Lab Epigenet & Dis, Dept Pharmacol & Toxicol, Sect 67, Mohali 160062, Punjab, India.
C3 National Institute of Pharmaceutical Education & Research, S.A.S. Nagar
   (Mohali)
RP Tikoo, K (corresponding author), Natl Inst Pharmaceut Educ & Res, Lab Epigenet & Dis, Dept Pharmacol & Toxicol, Sect 67, Mohali 160062, Punjab, India.
EM tikoo@niper.ac.in
OI Kabeer, Shaheen Wasil/0000-0002-6468-2317; PANT,
   RAJAT/0000-0003-3169-5151
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NR 40
TC 5
Z9 5
U1 4
U2 9
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0009-2797
EI 1872-7786
J9 CHEM-BIOL INTERACT
JI Chem.-Biol. Interact.
PD APR 1
PY 2023
VL 374
AR 110401
DI 10.1016/j.cbi.2023.110401
EA FEB 2023
PG 11
WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology
GA 9U9YR
UT WOS:000948059500001
PM 36828244
DA 2025-06-11
ER

PT J
AU Aref, M
   Movahedi, A
   Heidari-Beni, M
   Kelishadi, R
AF Aref, Maryam
   Movahedi, Ariyo
   Heidari-Beni, Motahar
   Kelishadi, Roya
TI Effects of shrimp oil on cardio-metabolic risk factors in children and
   adolescents
SO INTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCH
LA English
DT Article
DE Shrimp oil; anthropometric indices; metabolic syndrome; cardiovascular
   disease risk factors; childhood obesity
ID POLYUNSATURATED FATTY-ACIDS; OXIDATIVE STRESS; ASTAXANTHIN
AB Background: Antioxidants have beneficial effects on health. Shrimp oil has Astaxanthin and omega 3 that act as powerful antioxidants and might have anti-inflammatory effects on cardiovascular diseases. This study aims to investigate the effects of shrimp oil supplementation on cardio-metabolic risk factors in overweight and obese children and adolescents. Methods: This randomized, triple-blind, placebo-controlled clinical trial was conducted on 64 overweight and obese participants with 10-18 years of age. They were randomly assigned to receive either 500 mg shrimp oil or identical placebo that contained medium-chain trigtycerides once per day for eight weeks. Dietary intake was obtained using food record questionnaire for three days at baseline and at the end of the study. Fasting blood samples were obtained at baseline and after eight weeks of intervention. Results: Overall, 53 participants completed the study: 30 subjects received shrimp oil and 23 subjects received placebo. There were no significant effects of shrimp oil on total cholesterol, triglyceride, HDL-C, LDL-C and blood pressure compared with the placebo group (p>0.05). Shrimp oil had no significant effects on body mass index, waist circumference and hip circumference compared with the placebo group (p>0.05). Conclusions: Supplementation with shrimp oil had no significant effects on improving the anthropometric measures and cardio-metabolic risk factors. Future clinical trials are needed to investigate the beneficial effects of higher doses of shrimp oil on cardio-metabolic risk factors in the pediatric age groups.
C1 [Aref, Maryam] Islamic Azad Univ, Sci & Res Branch, Tehran, Iran.
   [Movahedi, Ariyo] Islamic Azad Univ, Dept Nutr, Sci & Res Branch, Tehran, Iran.
   [Heidari-Beni, Motahar] Isfahan Univ Med Sci, Child Growth & Dev Res Ctr, Res Inst Primordial Prevent Noncommunicable Dis, Dept Nutr, Esfahan, Iran.
   [Kelishadi, Roya] Isfahan Univ Med Sci, Child Growth & Dev Res Ctr, Res Inst Primordial Prevent Noncommunicable Dis, Dept Pediat, Esfahan, Iran.
C3 Islamic Azad University; Islamic Azad University; Isfahan University of
   Medical Sciences; Isfahan University of Medical Sciences
RP Heidari-Beni, M (corresponding author), Isfahan Univ Med Sci, Child Growth & Dev Res Ctr, Res Inst Primordial Prevent Noncommunicable Dis, Dept Nutr, Esfahan, Iran.
EM motahar.heidari@nutr.mui.ac.ir
RI Kelishadi, Roya/E-6154-2012; Heidari-Beni, Motahar/I-2972-2018
FU Isfahan University of Medical Sciences [295135]; 
   [IR.MUI.REC.1395.2.135]
FX This study was conducted as the Project number 295135 supported by
   Isfahan University of Medical Sciences (Research Ethics code:
   IR.MUI.REC.1395.2.135).
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NR 33
TC 0
Z9 0
U1 1
U2 7
PU IMR PRESS
PI ROBINSON
PA 112 ROBINSON RD, ROBINSON, SINGAPORE
SN 0300-9831
EI 1664-2821
J9 INT J VITAM NUTR RES
JI Int. J. Vitam. Nutr. Res.
PD DEC
PY 2023
VL 93
IS 6
BP 490
EP 497
DI 10.1024/0300-9831/a000755
EA MAR 2022
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA CF9C7
UT WOS:000771128600001
PM 35311593
DA 2025-06-11
ER

PT J
AU Goodarzi, R
   Jafarirad, S
   Mohammadtaghvaei, N
   Dastoorpoor, M
   Alavinejad, P
AF Goodarzi, Reza
   Jafarirad, Sima
   Mohammadtaghvaei, Narges
   Dastoorpoor, Maryam
   Alavinejad, Pejman
TI The effect of pomegranate extract on anthropometric indices, serum
   lipids, glycemic indicators, and blood pressure in patients with
   nonalcoholic fatty liver disease: A randomized double-blind clinical
   trial
SO PHYTOTHERAPY RESEARCH
LA English
DT Article
DE blood glucose; cholesterol; insulin; nonalcoholic fatty liver;
   pomegranate
ID INSULIN-RESISTANCE; ELLAGIC ACID; METABOLIC SYNDROME; OXIDATIVE STRESS;
   FUNCTIONAL FOOD; LIFE-STYLE; JUICE; OBESITY; INFLAMMATION; WEIGHT
AB Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease. The beneficial effects of pomegranate have been shown on insulin resistance and obesity, which are linked to NAFLD pathogenesis. The aim of this study was to investigate the efficacy of pomegranate extract in patients with NAFLD. Forty-four NAFLD patients were randomly assigned to receive two pomegranate extract tablets or placebo for 12 weeks. Anthropometric measurements, serum lipids, glycemic indicators, and blood pressure were assessed at baseline and the end of the study. Pomegranate was associated with a reduction in the total cholesterol (p < .001), triglyceride (p < .001), low-density lipoprotein cholesterol (LDL-C)-to-high-density lipoprotein cholesterol (HDL-C) ratio (p < .003), fasting blood sugar (p < .001), homeostatic model assessment of insulin resistance (p = .02), diastolic blood pressure (p = .04), weight (p < .001), body mass index (p < .001), and waist circumference (p = .002), as compared to placebo. A significant increase was observed in serum HDL-C (p < .001) after intervention with the pomegranate extract. However, no significant difference was shown between the two groups in serum insulin and LDL-C. The pomegranate extract supplement could be used as a complementary therapy along with existing therapies to improve glycemic indicators, serum lipids, anthropometric indices, and blood pressure in patients with nonalcoholic fatty liver.
C1 [Goodarzi, Reza; Jafarirad, Sima] Ahvaz Jundishapur Univ Med Sci, Nutr & Metab Dis Res Ctr, Clin Sci Res Inst, Ahvaz, Iran.
   [Goodarzi, Reza; Jafarirad, Sima] Ahvaz Jundishapur Univ Med Sci, Sch Allied Med Sci, Dept Nutr, Ahvaz, Iran.
   [Mohammadtaghvaei, Narges] Ahvaz Jundishapur Univ Med Sci, Hyperlipidemia Res Ctr, Ahvaz, Iran.
   [Dastoorpoor, Maryam] Ahvaz Jundishapur Univ Med Sci, Dept Biostat & Epidemiol, Ahvaz, Iran.
   [Alavinejad, Pejman] Ahvaz Jundishapur Univ Med Sci, Res Inst Infect Dis Digest Syst, Ahvaz, Iran.
C3 Ahvaz Jundishapur University of Medical Sciences (AJUMS); Ahvaz
   Jundishapur University of Medical Sciences (AJUMS); Ahvaz Jundishapur
   University of Medical Sciences (AJUMS); Ahvaz Jundishapur University of
   Medical Sciences (AJUMS); Ahvaz Jundishapur University of Medical
   Sciences (AJUMS)
RP Jafarirad, S (corresponding author), Ahvaz Jundishapur Univ Med Sci, Nutr & Metab Dis Res Ctr, Clin Sci Res Inst, Ahvaz, Iran.
EM sjafarirad@gmail.com
RI Dastoorpoor, Maryam/GLN-5519-2022; Dastoorpoor, Maryam/R-7335-2017;
   Jafarirad, Sima/I-3688-2018
OI Dastoorpoor, Maryam/0000-0001-5268-334X; Goodarzi,
   Reza/0000-0001-7369-1381; Jafarirad, Sima/0000-0002-3161-5329
FU Ahvaz Jundishapur University of Medical Sciences [NRC-9811]
FX Ahvaz Jundishapur University of Medical Sciences, Grant/Award Number:
   NRC-9811
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NR 58
TC 23
Z9 23
U1 1
U2 17
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0951-418X
EI 1099-1573
J9 PHYTOTHER RES
JI Phytother. Res.
PD OCT
PY 2021
VL 35
IS 10
BP 5871
EP 5882
DI 10.1002/ptr.7249
EA SEP 2021
PG 12
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA WL6EZ
UT WOS:000693758100001
PM 34498307
DA 2025-06-11
ER

PT J
AU Veskovic, M
   Labudovic-Borovic, M
   Mladenovic, D
   Jadzic, J
   Jorgacevic, B
   Vukicevic, D
   Vucevic, D
   Radosavljevic, T
AF Veskovic, Milena
   Labudovic-Borovic, Milica
   Mladenovic, Dusan
   Jadzic, Jelena
   Jorgacevic, Bojan
   Vukicevic, Dusan
   Vucevic, Danijela
   Radosavljevic, Tatjana
TI Effect of Betaine Supplementation on Liver Tissue and Ultrastructural
   Changes in Methionine-Choline-Deficient Diet-Induced NAFLD
SO MICROSCOPY AND MICROANALYSIS
LA English
DT Article
DE autophagosomes; betaine; mitochondria; nonalcoholic fatty liver disease;
   ultrastructure
ID NONALCOHOLIC FATTY LIVER; OXIDATIVE STRESS; LIPID-METABOLISM;
   ANIMAL-MODELS; DISEASE; STEATOHEPATITIS; AUTOPHAGY; MICE; PATHOGENESIS;
   INFLAMMATION
AB Nonalcoholic fatty liver disease (NAFLD) represents a hepatic manifestation of metabolic syndrome. The aim of this study was to examine the effect of betaine on ultrastructural changes in the mouse liver with methionine- and choline-deficient (MCD) diet-induced NAFLD. Male C57BL/6 mice were divided into groups: Control-fed with standard chow, BET-standard chow supplemented with betaine (1.5% w/v drinking water), MCD-fed with MCD diet, and MCD + BET-MCD diet with betaine supplementation for 6 weeks. Liver samples were taken for pathohistology and transmission electron microscopy. The MCD diet-induced steatosis, inflammation, and balloon-altered hepatocytes were alleviated by betaine. MCD diet induced an increase in mitochondrial size versus the control group (p< 0.01), which was decreased in the betaine-treated group. In the MCD diet-fed group, the total mitochondrial count decreased versus the control group (p< 0.01), while it increased in the MCD + BET group versus MCD (p< 0.01). Electron microscopy showed an increase in the number of autophagosomes in the MCD and MCD + BET group versus control, and a significant difference in autophagosomes number was detected in the MCD + BET group by comparison with the MCD diet-treated group (p< 0.05). Betaine decreases the number of enlarged mitochondria, alleviates steatosis, and increases the number of autophagosomes in the liver of mice with NAFLD.
C1 [Veskovic, Milena; Mladenovic, Dusan; Jorgacevic, Bojan; Vukicevic, Dusan; Vucevic, Danijela; Radosavljevic, Tatjana] Univ Belgrade, Fac Med, Inst Pathophysiol, Dr Subotica 9, Belgrade 11000, Serbia.
   [Labudovic-Borovic, Milica] Univ Belgrade, Fac Med, Inst Histol & Embryol, Belgrade 11000, Serbia.
   [Jadzic, Jelena] Univ Belgrade, Fac Med, Inst Anat, Belgrade 11000, Serbia.
C3 University of Belgrade; University of Belgrade; University of Belgrade
RP Radosavljevic, T (corresponding author), Univ Belgrade, Fac Med, Inst Pathophysiol, Dr Subotica 9, Belgrade 11000, Serbia.
EM tatjana.radosavljevic@med.bg.ac.rs
RI Radosavljević, Tatjana/AAE-2792-2020; Veskovic, Milena/U-4519-2019;
   Jadzic, Jelena/GWU-6755-2022
OI Veskovic, Milena/0000-0002-7505-5466; Jadzic,
   Jelena/0000-0002-3124-1400; Labudovic Borovic,
   Milica/0000-0003-1471-0014; Mladenovic, Dusan/0000-0002-8921-6232;
   Radosavljevic, Tatjana/0000-0002-1701-3313
FU Ministry of Education, Science and Technological Development of the
   Republic of Serbia [175015]
FX This research was financially supported by the Ministry of Education,
   Science and Technological Development of the Republic of Serbia (Grant
   No. 175015).
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NR 54
TC 17
Z9 18
U1 0
U2 20
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
SN 1431-9276
EI 1435-8115
J9 MICROSC MICROANAL
JI Microsc. microanal.
PD OCT
PY 2020
VL 26
IS 5
BP 997
EP 1006
AR PII S1431927620024265
DI 10.1017/S1431927620024265
PG 10
WC Materials Science, Multidisciplinary; Microscopy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Materials Science; Microscopy
GA NZ1OD
UT WOS:000576859800015
PM 32782033
DA 2025-06-11
ER

PT J
AU Graff, EC
   Fang, H
   Wanders, D
   Judd, RL
AF Graff, Emily C.
   Fang, Han
   Wanders, Desiree
   Judd, Robert L.
TI The Absence of Adiponectin Alters Niacin's Effects on Adipose Tissue
   Inflammation in Mice
SO NUTRIENTS
LA English
DT Article
DE obesity; inflammation; immune; niacin; adipokines
ID HIGH-FAT DIET; MONOCYTE CHEMOATTRACTANT PROTEIN-1; MOLECULAR-WEIGHT
   ADIPONECTIN; NICOTINIC-ACID; VASCULAR INFLAMMATION;
   MACROPHAGE-MIGRATION; INSULIN SENSITIVITY; PLASMA ADIPONECTIN; METABOLIC
   SYNDROME; OXIDATIVE STRESS
AB Obesity is an immunometabolic disease associated with chronic inflammation and the dysregulation of pro- and anti-inflammatory cytokines. One hallmark of obesity is reduced concentrations of the anti-inflammatory adipokine, adiponectin. Pharmacologic doses of niacin produce multiple metabolic benefits, including attenuating high-fat diet (HFD)-induced adipose tissue inflammation and increasing adiponectin concentrations. To determine if adiponectin mediates the anti-inflammatory effects of niacin, male C57BL/6J (WT) and adiponectin null (Adipoq(-/-)) mice were maintained on a low-fat diet (LFD) or HFD for 6 weeks, before being administered either vehicle or niacin (360 mg/kg/day) for 5 weeks. HFD-fed mice had increased expression of genes associated with macrophage recruitment (Ccl2) and number (Cd68), and increased crown-like structure (CLS) number in adipose tissue. While niacin attenuatedCcl2expression, there were no effects onCd68or CLS number. The absence of adiponectin did not hinder the ability of niacin to reduceCcl2expression. HFD feeding increased gene expression of inflammatory markers in the adipose tissue of WT andAdipoq(-/-)mice. While niacin tended to decrease the expression of inflammatory markers in WT mice, niacin increased their expression in HFD-fedAdipoq(-/-)mice. Therefore, our results indicate that the absence of adiponectin alters the effects of niacin on markers of adipose tissue inflammation in HFD-fed mice, suggesting that the effects of niacin on tissue cytokines may involve adiponectin.
C1 [Graff, Emily C.] Auburn Univ, Dept Pathobiol, Auburn, AL 36849 USA.
   [Graff, Emily C.] Auburn Univ, Scott Ritchey Res Ctr, Auburn, AL 36849 USA.
   [Fang, Han] Louisiana State Univ, Pennington Biomed Res Ctr, Baton Rouge, LA 70808 USA.
   [Wanders, Desiree] Georgia State Univ, Dept Nutr, Atlanta, GA 30302 USA.
   [Judd, Robert L.] Auburn Univ, Dept Anat Physiol & Pharmacol, Auburn, AL 36849 USA.
C3 Auburn University System; Auburn University; Auburn University System;
   Auburn University; Louisiana State University System; Louisiana State
   University; Pennington Biomedical Research Center; University System of
   Georgia; Georgia State University; Auburn University System; Auburn
   University
RP Judd, RL (corresponding author), Auburn Univ, Dept Anat Physiol & Pharmacol, Auburn, AL 36849 USA.
EM ecg0001@auburn.edu; han.fang@pbrc.edu; dwanders@gsu.edu;
   juddrob@auburn.edu
OI Graff, Emily/0000-0002-2141-0864
FU Diabetes Action Research and Education Foundation; Boshell Diabetes and
   Metabolic Disease Research Program
FX Diabetes Action Research and Education Foundation and Boshell Diabetes
   and Metabolic Disease Research Program.
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NR 69
TC 5
Z9 7
U1 0
U2 7
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD AUG
PY 2020
VL 12
IS 8
AR 2427
DI 10.3390/nu12082427
PG 14
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA OA4YC
UT WOS:000577791700001
PM 32823541
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Sfera, A
   Osorio, C
   Diaz, EL
   Maguire, G
   Cummings, M
AF Sfera, Adonis
   Osorio, Carolina
   Diaz, Eddie Lee
   Maguire, Gerald
   Cummings, Michael
TI The Other Obesity Epidemic-Of Drugs and Bugs
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Review
DE obesity; psychotropic drugs; Bacteroidetes phylum; xenobiotic sensors;
   antimicrobials
ID PREGNANE-X RECEPTOR; ARYL-HYDROCARBON RECEPTOR; CHAIN FATTY-ACIDS;
   DIET-INDUCED OBESITY; GUT MICROBIOTA; METABOLIC SYNDROME; OXIDATIVE
   STRESS; VALPROIC ACID; AH RECEPTOR; WEIGHT-GAIN
AB Chronic psychiatric patients with schizophrenia and related disorders are frequently treatment-resistant and may require higher doses of psychotropic drugs to remain stable. Prolonged exposure to these agents increases the risk of weight gain and cardiometabolic disorders, leading to poorer outcomes and higher medical cost. It is well-established that obesity has reached epidemic proportions throughout the world, however it is less known that its rates are two to three times higher in mentally ill patients compared to the general population. Psychotropic drugs have emerged as a major cause of weight gain, pointing to an urgent need for novel interventions to attenuate this unintended consequence. Recently, the gut microbial community has been linked to psychotropic drugs-induced obesity as these agents were found to possess antimicrobial properties and trigger intestinal dysbiosis, depleting Bacteroidetes phylum. Since germ-free animals exposed to psychotropics have not demonstrated weight gain, altered commensal flora composition is believed to be necessary and sufficient to induce dysmetabolism. Conversely, not only do psychotropics disrupt the composition of gut microbiota but the later alter the metabolism of the former. Here we review the role of gut bacterial community in psychotropic drugs metabolism and dysbiosis. We discuss potential biomarkers reflecting the status of Bacteroidetes phylum and take a closer look at nutritional interventions, fecal microbiota transplantation, and transcranial magnetic stimulation, strategies that may lower obesity rates in chronic psychiatric patients.
C1 [Sfera, Adonis] Loma Linda Univ, Psychiat, Loma Linda, CA 92350 USA.
   [Sfera, Adonis; Diaz, Eddie Lee; Cummings, Michael] Patton State Hosp, Dept Psychiat, Patton, CA 92369 USA.
   [Osorio, Carolina] Loma Linda Univ, Dept Psychiat, Loma Linda, CA 92350 USA.
   [Maguire, Gerald] Univ Calif Riverside, Dept Psychiat, Riverside, CA 92521 USA.
C3 Loma Linda University; Loma Linda University; University of California
   System; University of California Riverside
RP Sfera, A (corresponding author), Loma Linda Univ, Psychiat, Loma Linda, CA 92350 USA.; Sfera, A (corresponding author), Patton State Hosp, Dept Psychiat, Patton, CA 92369 USA.
EM dr.sfera@gmail.com
RI Sfera, Adonis/JXL-1291-2024
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NR 194
TC 6
Z9 7
U1 0
U2 8
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD JUL 31
PY 2020
VL 11
AR 488
DI 10.3389/fendo.2020.00488
PG 16
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism
GA ND8QV
UT WOS:000562168200001
PM 32849279
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Armstrong, LE
   Muñoz, CX
   Armstrong, EM
AF Armstrong, Lawrence E.
   Munoz, Colleen X.
   Armstrong, Elizabeth M.
TI Distinguishing Low and High Water Consumers-A Paradigm of Disease Risk
SO NUTRIENTS
LA English
DT Review
DE arginine vasopressin; cortisol; plasma osmolality; dietary protein;
   dietary salt; thirst
ID PITUITARY-ADRENAL AXIS; CHRONIC KIDNEY-DISEASE; DIETARY-PROTEIN INTAKE;
   PLANT-BASED DIETS; PLASMA VASOPRESSIN; HYDRATION STATUS;
   ARGININE-VASOPRESSIN; SURROGATE MARKER; URINE COLOR;
   ANTIDIURETIC-HORMONE
AB A long-standing body of clinical observations associates low 24-h total water intake (TWI = water + beverages + food moisture) with acute renal disorders such as kidney stones and urinary tract infections. These findings prompted observational studies and experimental interventions comparing habitual low volume (LOW) and high volume (HIGH) drinkers. Investigators have learned that the TWI of LOW and HIGH differ by 1-2 Ld(-1), their hematological values (e.g., plasma osmolality, plasma sodium) are similar and lie within the laboratory reference ranges of healthy adults and both groups appear to successfully maintain water-electrolyte homeostasis. However, LOW differs from HIGH in urinary biomarkers (e.g., reduced urine volume and increased osmolality or specific gravity), as well as higher plasma concentrations of arginine vasopressin (AVP) and cortisol. Further, evidence suggests that both a low daily TWI and/or elevated plasma AVP influence the development and progression of metabolic syndrome, diabetes, obesity, chronic kidney disease, hypertension and cardiovascular disease. Based on these studies, we propose a theory of increased disease risk in LOW that involves chronic release of fluid-electrolyte (i.e., AVP) and stress (i.e., cortisol) hormones. This narrative review describes small but important differences between LOW and HIGH, advises future investigations and provides practical dietary recommendations for LOW that are intended to decrease their risk of chronic diseases.
C1 [Armstrong, Lawrence E.] Univ Connecticut, Human Performance Lab, Storrs, CT 06269 USA.
   [Armstrong, Lawrence E.] Univ Connecticut, Dept Nutr Sci, Storrs, CT 06269 USA.
   [Munoz, Colleen X.] Univ Hartford, Dept Hlth Sci, Hartford, CT 06117 USA.
   [Armstrong, Elizabeth M.] Riverside Behav Hlth Ctr, Hampton, VA 23666 USA.
C3 University of Connecticut; University of Connecticut; University of
   Hartford
RP Armstrong, LE (corresponding author), Univ Connecticut, Human Performance Lab, Storrs, CT 06269 USA.; Armstrong, LE (corresponding author), Univ Connecticut, Dept Nutr Sci, Storrs, CT 06269 USA.
EM Lawrence.Armstrong@uconn.edu; cmunoz@hartford.edu;
   elizabeth.armstrong@rivhs.com
OI Armstrong, Lawrence/0000-0002-9230-6925
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NR 146
TC 26
Z9 26
U1 1
U2 8
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD MAR
PY 2020
VL 12
IS 3
AR 858
DI 10.3390/nu12030858
PG 28
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA LL8VB
UT WOS:000531831000267
PM 32210168
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Siddeek, B
   Mauduit, C
   Simeoni, U
   Benahmed, M
AF Siddeek, Benazir
   Mauduit, Claire
   Simeoni, Umberto
   Benahmed, Mohamed
TI Sperm epigenome as a marker of environmental exposure and lifestyle, at
   the origin of diseases inheritance
SO MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH
LA English
DT Review
DE Epigenome; Environment; Sperm; Intergenerational
ID GERM-CELL DEATH; DNA METHYLATION; TRANSGENERATIONAL INHERITANCE;
   PATERNAL AGE; EPIGENETIC INHERITANCE; OCCUPATIONAL-EXPOSURE; HISTONE
   METHYLATION; GENOME INSTABILITY; METABOLIC SYNDROME; CIGARETTE-SMOKING
AB Paternal exposure to environmental challenges plays a critical role in the offspring's future health and the transmission of acquired traits through generations. This review summarizes our current knowledge in the new field of epigenomic paternal transmission of health and disease. Epidemiological studies identified that paternal ageing or challenges (imbalanced diets, stress, toxicants, cigarette smoke, alcohol) increased the risk of offspring to develop diseases such as cancer, metabolic, cardiovascular, and neurological diseases. These data were confirmed and deepened in animal models of exposure to challenges including low-protein, low-folate, high-fat diets, exposure to chemicals such as pesticides and herbicides. Even though some toxicants have mutagenic effect on sperm DNA, changes in sperm epigenome seem to be a common thread between different types of challenges. Indeed, epigenetic changes (DNA methylation, chromatin remodeling, small non-coding RNA) in sperm are described as new mechanisms of intergenerational transmission as demonstrated for dioxin, for example. Those epimutations induce dysregulation in genes expression involved in key cellular pathways such as reactive oxygen species and genome stability regulation, in brain-derived neurotrophic factor, calcium and glucocorticoid signaling, and in lipid and glucose metabolism, leading to diseases in offspring. Finally, since each type of environmental challenges has its own signature by inducing epimutations at specific genomic loci, the sperm epigenome might be used as a biomarker in toxicological and risk assessments.
C1 [Siddeek, Benazir; Simeoni, Umberto] CHU Vaudois, DOHaD Lab, Woman Mother Child Department, Div Pediat, Rue Bugnon 46, CH-1011 Lausanne, Switzerland.
   [Siddeek, Benazir; Simeoni, Umberto] Univ Lausanne, Rue Bugnon 46, CH-1011 Lausanne, Switzerland.
   [Mauduit, Claire; Benahmed, Mohamed] INSERM, U1065, Ctr Mediterraneen Med Mol C3M, Team 5, F-06204 Nice, France.
C3 University of Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV);
   University of Lausanne; Institut National de la Sante et de la Recherche
   Medicale (Inserm); Universite Cote d'Azur
RP Siddeek, B (corresponding author), CHU Vaudois, DOHaD Lab, Woman Mother Child Department, Div Pediat, Rue Bugnon 46, CH-1011 Lausanne, Switzerland.; Siddeek, B (corresponding author), Univ Lausanne, Rue Bugnon 46, CH-1011 Lausanne, Switzerland.
EM Benazir.Siddeek@chuv.ch
RI SIMEONI, Umberto/AAQ-1870-2021; Simeoni, Umberto/GRO-6971-2022
OI Simeoni, Umberto/0000-0003-0730-9337; SIDDEEK,
   Benazir/0000-0003-2764-6656; mauduit, claire/0000-0001-7835-2610
FU Centre Hospitalier Universitaire Vaudoix
FX This work was supported by the Centre Hospitalier Universitaire Vaudoix.
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NR 112
TC 45
Z9 49
U1 2
U2 28
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1383-5742
EI 1388-2139
J9 MUTAT RES-REV MUTAT
JI Mutat. Res.-Rev. Mutat. Res.
PD OCT-DEC
PY 2018
VL 778
BP 38
EP 44
DI 10.1016/j.mrrev.2018.09.001
PG 7
WC Biotechnology & Applied Microbiology; Genetics & Heredity; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Genetics & Heredity; Toxicology
GA HC0MB
UT WOS:000451491400004
PM 30454681
DA 2025-06-11
ER

PT J
AU Hurley, MJ
   Deacon, RMJ
   Beyer, K
   Ioannou, E
   Ibáñez, A
   Teeling, JL
   Cogram, P
AF Hurley, Michael J.
   Deacon, Robert M. J.
   Beyer, Katrin
   Ioannou, Elena
   Ibanez, Agustin
   Teeling, Jessica L.
   Cogram, Patricia
TI The long-lived Octodon degus as a rodent drug discovery model for
   Alzheimer's and other age-related diseases
SO PHARMACOLOGY & THERAPEUTICS
LA English
DT Review
DE Alzheimer's disease; beta-Amyloid; Degu; Neurodegeneration;
   Neuroinflammation; Octodon degus
ID MILD COGNITIVE IMPAIRMENT; CENTRAL-NERVOUS-SYSTEM; DUAL-PHASING RODENT;
   NATURAL MODEL; MELATONIN SYNTHESIS; DIURNAL RODENT; RISK-FACTORS;
   MEMANTINE; INSULIN; BRAIN
AB Alzheimer's disease (AD) is a multifactorial progressive neurodegenerative disease. Despite decades of research, no disease modifying therapy is available and a change of research objectives and/or development of novel research tools may be required. Much AD research has been based on experimental models using animals with a short lifespan that have been extensively genetically manipulated and do not represent the full spectrum of late-onset AD, which make up the majority of cases. The aetiology of AD is heterogeneous and involves multiple factors associated with the late-onset of the disease like disturbances in brain insulin, oxidative stress, neuroinflammation, metabolic syndrome, retinal degeneration and sleep disturbances which are all progressive abnormalities that could account for many molecular, biochemical and histopathological lesions found in brain from patients dying from AD. This review is based on the long-lived rodent Octodon degus (degu) which is a small diurnal rodent native to South America that can spontaneously develop cognitive decline with concomitant phospho-tau, beta-amyloid pathology and neuroinflammation in brain. In addition, the degu can also develop several other conditions like type 2 diabetes, macular and retinal degeneration and atherosclerosis, conditions that are often associated with aging and are often comorbid with AD. Long-lived animals like the degu may provide a more realistic model to study late onset AD. (C) 2018 Elsevier Inc. All rights reserved.
C1 [Hurley, Michael J.; Teeling, Jessica L.] Univ Southampton, Biol Sci, Neuroimmunol, Southampton SO16 6YD, Hants, England.
   [Hurley, Michael J.; Ioannou, Elena] Imperial Coll London, Dept Med, Neuroinflammat & Neurodegenerat, London W12 0NN, England.
   [Deacon, Robert M. J.; Ibanez, Agustin; Cogram, Patricia] Favaloro Univ, Mol Neuropsychiat, Inst Cognit & Translat Neurosci, INECO Fdn,Natl Sci & Tech Res Council, Buenos Aires, DF, Argentina.
   [Deacon, Robert M. J.; Cogram, Patricia] Fraunhofer Inst, Aachen, Germany.
   [Deacon, Robert M. J.; Cogram, Patricia] Univ Chile, Fac Sci, Inst Ecol & Biodivers, Santiago, Chile.
   [Beyer, Katrin] Germans Trios Pujol Res Inst, Dept Pathol, Badalona 08916, Spain.
   [Ioannou, Elena] UCL, Inst Ophthalmol, Cell Biol, London EC1V 9EL, England.
   [Ibanez, Agustin] Univ Autonoma Caribe, Barranquilla, Colombia.
   [Ibanez, Agustin] Univ Adolfo lbanez, Sch Psychol, CSCN, Santiago, Chile.
   [Ibanez, Agustin] ACR, Ctr Excellence Cognit & Its Disorders, Sydney, NSW, Australia.
C3 University of Southampton; Imperial College London; Fraunhofer
   Gesellschaft; Fraunhofer Germany; Universidad de Chile; University of
   London; University College London
RP Cogram, P (corresponding author), Univ Chile, Fac Sci, Inst Ecol & Biodivers, Santiago, Chile.
EM patricia.cogram@gmail.com
RI Beyer, Katrin/C-3001-2017; Teeling, Jessica/HPE-2192-2023; Ibanez,
   Agustin/H-7976-2015
OI Ioannou, Elena/0000-0002-8482-8360; Ibanez, Agustin/0000-0001-6758-5101;
   Teeling, Jessica/0000-0003-4004-7391; Hurley,
   Michael/0000-0001-8022-9283
FU CONICET; CONICYT/FONDECYT [1170010]; FONDAP [15150012]; INECO Foundation
FX The authors gratefully acknowledge the support, encouragement and
   suggestions offered by Professor Dr. Wolfgang Schuch to our work with
   Octodon degus. AI is partially supported by CONICET, CONICYT/FONDECYT
   (Regular 1170010), FONDAP (15150012), and the INECO Foundation.
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NR 113
TC 23
Z9 24
U1 0
U2 15
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0163-7258
J9 PHARMACOL THERAPEUT
JI Pharmacol. Ther.
PD AUG
PY 2018
VL 188
BP 36
EP 44
DI 10.1016/j.pharmthera.2018.03.001
PG 9
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Pharmacology & Pharmacy
GA GQ2ML
UT WOS:000441489000004
PM 29514054
OA Green Accepted, Green Submitted
DA 2025-06-11
ER

PT J
AU Luo, T
   Miranda-Garcia, O
   Sasaki, G
   Shay, NF
AF Luo, T.
   Miranda-Garcia, O.
   Sasaki, G.
   Shay, N. F.
TI Consumption of a single serving of red raspberries per day reduces
   metabolic syndrome parameters in high-fat fed mice
SO FOOD & FUNCTION
LA English
DT Article
ID ELLAGIC ACID; HEALTH; INFLAMMATION; MECHANISMS; OBESITY
AB Using an animal model for diet-induced metabolic disease, we have shown previously that the addition of raspberry juice concentrate (RJC) and raspberry puree concentrate (RPC) at a level of 10% of kcal, equivalent to four servings per day, to an obesogenic high-fat, western-style diet (HF) significantly reduced body weight gain, serum resistin levels, and altered the expression of hepatic genes related to lipid metabolism and oxidative stress. This study was designed to examine the effect of a lower level of RJC or RPC consumption, at a level representing a single serving of food per day (2.5% of kcal). For ten weeks, four groups of C57BL/6J mice (n = 8 ea.) were fed: low fat (LF), HF, HF + RJC, or HF + RPC diets. Intake of RJC and RPC decreased final body weight. Hepatic lipid accumulation was significantly decreased in HF + RPC- and HF + RJC-fed mice, compared to HF-fed mice. Further, the relative expression of hepatic genes including Heme oxygenase 1 (Hmox1) and Hormone sensitive lipase (Lipe), were altered by RPC or RJC consumption. In this mouse model of diet-induced metabolic disease, consumption of the equivalent of a single daily serving of either RPC or RJC improved metabolism in mice fed HF diet. We hypothesize that the phytochemicals contained in raspberries, and/or their subsequent metabolites, may be acting to influence gene expression and other regulatory pathways, to produce the metabolic improvements observed in this study.
C1 [Luo, T.; Miranda-Garcia, O.; Sasaki, G.; Shay, N. F.] Oregon State Univ, Dept Food Sci & Technol, Coll Agr Sci, Corvallis, OR 97331 USA.
C3 Oregon State University
RP Shay, NF (corresponding author), Oregon State Univ, Dept Food Sci & Technol, Coll Agr Sci, Corvallis, OR 97331 USA.
EM neil.shay@oregonstate.edu
RI Luo, Ting/O-7773-2019
FU National Processed Raspberry Council (USA)
FX This research was supported by National Processed Raspberry Council
   (USA).
CR Andrikopoulos S, 2008, AM J PHYSIOL-ENDOC M, V295, pE1323, DOI 10.1152/ajpendo.90617.2008
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   US Department of Agriculture, National nutrient database for standard reference release 17
NR 24
TC 16
Z9 19
U1 0
U2 15
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PD NOV
PY 2017
VL 8
IS 11
BP 4081
EP 4088
DI 10.1039/c7fo00702g
PG 8
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA FM9HW
UT WOS:000415578600023
PM 28984888
DA 2025-06-11
ER

PT J
AU Kim, J
   Lee, H
   Lim, J
   Lee, H
   Yoon, S
   Shin, SS
   Yoon, M
AF Kim, Jeongjun
   Lee, Hyunghee
   Lim, Jonghoon
   Lee, Haerim
   Yoon, Seolah
   Shin, Soon Shik
   Yoon, Michung
TI The lemon balm extract ALS-L1023 inhibits obesity and nonalcoholic fatty
   liver disease in female ovariectomized mice
SO FOOD AND CHEMICAL TOXICOLOGY
LA English
DT Article
DE Melissa officinalis; Angiogenesis; Antioxidation; Fibrosis;
   Inflammation; Steatosis; Visceral adipose tissue
ID ADIPOSE-TISSUE DYSFUNCTION; INDUCED OXIDATIVE STRESS; COMPOSITION OB-X;
   MELISSA-OFFICINALIS; INSULIN-RESISTANCE; PPAR-ALPHA;
   CHOLESTEROL-SYNTHESIS; METABOLIC SYNDROME; INDUCED APOPTOSIS; VISCERAL
   OBESITY
AB Increasing evidence indicates that angiogenesis inhibitors regulate obesity. This study aimed to determine whether the lemon balm extract ALS-L1023 inhibits diet-induced obesity and nonalcoholic fatty liver disease (NAFLD) in female ovariectomized (OVX) mice. OVX mice received a low fat diet (LFD), a high fat diet (HFD) or HFD supplemented with ALS-L1023 (ALS-L1023) for 15 weeks. HFD mice exhibited increases in visceral adipose tissue (VAT) angiogenesis, body weight, VAT mass and VAT inflammation compared with LFD mice. In contrast, all of these effects were reduced in ALS-L1023 mice compared with HFD mice. Serum lipids and liver injury markers were improved in ALS-L1023 mice. Hepatic lipid accumulation, inflammatory cells and collagen levels were lower in ALS-L1023 mice than in HFD mice. ALS-L1023 mice exhibited a tendency to normalize hepatic expression of genes involved in lipid metabolism, inflammation and fibrosis to levels in LFD mice. ALS-L1023 also induced Akt phosphorylation and increased Nrf2 mRNA expression in livers of obese mice. Our results indicate that the angiogenesis inhibitor ALS-L1023 can regulate obesity, hepatic steatosis and fibro-inflammation, in-part through improvement of VAT function, in obese OVX mice. These findings suggest that angiogenesis inhibitors may contribute to alleviation of NAFLD in post-menopausal women with obesity. (C) 2017 Elsevier Ltd. All rights reserved.
C1 [Kim, Jeongjun; Lee, Hyunghee; Lim, Jonghoon; Lee, Haerim; Yoon, Seolah; Yoon, Michung] Mokwon Univ, Dept Biomed Engn, Daejeon 302729, South Korea.
   [Shin, Soon Shik] Dong Eui Univ, Dept Formula Sci, Coll Korean Med, Busan 614052, South Korea.
C3 Mokwon University; Dong-Eui University
RP Yoon, M (corresponding author), Mokwon Univ, Dept Biomed Engn, Daejeon 302729, South Korea.; Shin, SS (corresponding author), Dong Eui Univ, Dept Formula Sci, Coll Korean Med, Busan 614052, South Korea.
EM ssshin@deu.ac.kr; yoon60@mokwon.ac.kr
RI Lee, Jong-Sub/G-2752-2012
FU National Research Foundation of Korea (NRF) Grants - Korea Government
   (NEST) [2015R1A1A3A04001016]; Korea Health Industry Development
   Institute (KHIDI) Grant - Korea Government (MHW) [HI15C0075, HI16C0753]
FX This work was supported by the National Research Foundation of Korea
   (NRF) Grants funded by the Korea Government (NEST) (2015R1A1A3A04001016)
   and the Korea Health Industry Development Institute (KHIDI) Grant funded
   by the Korea Government (MHW) (HI15C0075 and HI16C0753).
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NR 74
TC 23
Z9 25
U1 0
U2 20
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0278-6915
EI 1873-6351
J9 FOOD CHEM TOXICOL
JI Food Chem. Toxicol.
PD AUG
PY 2017
VL 106
BP 292
EP 305
DI 10.1016/j.fct.2017.05.059
PN A
PG 14
WC Food Science & Technology; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Toxicology
GA FA0XS
UT WOS:000405160600031
PM 28571771
DA 2025-06-11
ER

PT J
AU Zhuang, ST
   Li, Q
   Cai, LR
   Wang, C
   Lei, XG
AF Zhuang, Shentian
   Li, Qiang
   Cai, Lirong
   Wang, Chu
   Lei, Xiaoguang
TI Chemoproteomic Profiling of Bile Acid Interacting Proteins
SO ACS CENTRAL SCIENCE
LA English
DT Article
ID NONALCOHOLIC-FATTY-LIVER; FARNESOID-X-RECEPTOR; NUCLEAR RECEPTOR;
   TAUROURSODEOXYCHOLIC ACID; ALZHEIMERS-DISEASE; EMERGING ROLE;
   OBETICHOLIC ACID; BINDING-PROTEINS; VIBRIO-CHOLERAE; HOST METABOLISM
AB Bile acids (BAs) are a family of endogenous metabolites synthesized from cholesterol in liver and modified by microbiota in gut. Being amphipathic molecules, the major function of BAs is to help with dietary lipid digestion. In addition, they also act as signaling molecules to regulate lipid and glucose, metabolism as well as gut microbiota composition in the host. Remarkably, recent discoveries of the dedicated receptors for BAs such as FXR and TGRS have uncovered a number of novel actions of BAs as signaling hormones which play significant roles in both physiological and pathological conditions. Disorders in BAs' metabolism are closely related to metabolic syndrome and intestinal and neurodegenerative diseases. Though BA-based therapies have been clinically implemented for decades, the regulatory mechanism of BA is still poorly understood and a comprehensive characterization of BA-interacting proteins in proteome remains elusive. We herein describe a chemoproteomic strategy that uses a number of structurally diverse, clickable, and photoreactive BA-based probes in combination with quantitative mass spectrometry to globally profile BA-interacting proteins in mammalian, cells. Over 600 BA-interacting protein targets were identified, including known endogenous receptors and transporters of BA. Analysis of these novel BA-interacting proteins revealed that they are mainly enriched in functional pathways such as endoplasmic reticulum (ER) stress response and lipid metabolism, and are predicted with strong implications with Alzheimer's disease, non-alcoholic fatty liver disease, and diarrhea. Our findings will significantly improve the current understanding of BAs' regulatory roles in human physiology and diseases.
C1 [Zhuang, Shentian; Li, Qiang; Cai, Lirong; Wang, Chu; Lei, Xiaoguang] Minist Educ, Synthet & Funct Biomol Ctr, Beijing Natl Lab Mol Sci, Key Lab Bioorgan Chem & Mol Engn, Beijing 100871, Peoples R China.
   [Li, Qiang; Cai, Lirong; Wang, Chu; Lei, Xiaoguang] Coll Chem & Mol Engn, Dept Biol Chem, Beijing 100871, Peoples R China.
   [Zhuang, Shentian; Wang, Chu; Lei, Xiaoguang] Peking Univ, Peking Tsinghua Ctr Life Sci, Beijing 100871, Peoples R China.
C3 Ministry of Education - China; Chinese Academy of Sciences; Peking
   University
RP Wang, C; Lei, XG (corresponding author), Minist Educ, Synthet & Funct Biomol Ctr, Beijing Natl Lab Mol Sci, Key Lab Bioorgan Chem & Mol Engn, Beijing 100871, Peoples R China.; Wang, C; Lei, XG (corresponding author), Coll Chem & Mol Engn, Dept Biol Chem, Beijing 100871, Peoples R China.; Wang, C; Lei, XG (corresponding author), Peking Univ, Peking Tsinghua Ctr Life Sci, Beijing 100871, Peoples R China.
EM chuwang@pku.edu.cn; xglei@pku.edu.cn
RI Cai, lr/MBV-4199-2025; Wang, Chu/C-4442-2015
OI Wang, Chu/0000-0002-6925-1268
FU NNSFC [21472010, 21521003, 21561142002, 21625201, 21472008, 81490741];
   Ministry of Science and Technology of China [2015CB856200,
   2016YFA0501500]; "1000 Talents Plan" Young Investigator Award
FX We thank Prof. Wenhui Li (NIBS) for helpful discussion, Runze Tian for
   research assistance, and Prof. Jiang Zhou (PKU) for HRMS analysis. We
   also thank the Computing Platform of the Center for Life Science for
   supporting the proteomic data analysis. Financial support from NNSFC
   (21472010, 21521003, 21561142002, and 21625201 to X.L.; and 21472008 and
   81490741 to C.W.) and Ministry of Science and Technology of China
   (2015CB856200 to X.L. and 2016YFA0501500 to C.W.) is gratefully
   acknowledged. C.W. is supported by a "1000 Talents Plan" Young
   Investigator Award.
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NR 80
TC 121
Z9 133
U1 8
U2 120
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 2374-7943
EI 2374-7951
J9 ACS CENTRAL SCI
JI ACS Central Sci.
PD MAY
PY 2017
VL 3
IS 5
BP 501
EP 509
DI 10.1021/acscentsci.7b00134
PG 9
WC Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry
GA EW4VM
UT WOS:000402499000021
PM 28573213
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Morsy, MA
   Ibrahim, MA
   Abd-Elghany, MI
AF Morsy, Mohamed A.
   Ibrahim, Mohamed A.
   Abd-Elghany, Manal I.
TI Dimethyl dimethoxy biphenyl dicarboxylate attenuates hepatic and
   metabolic alterations in high fructose-fed rats
SO TOXICOLOGY AND INDUSTRIAL HEALTH
LA English
DT Article
DE DDB; metabolic syndrome; high fructose-feeding; insulin resistance;
   iNOS; uric acid
ID INSULIN-RESISTANCE; OXIDATIVE STRESS; LIVER; DDB; EXPRESSION; DIETARY;
   EXTRACT; MUSCLE; INJURY; ALPHA
AB High fructose consumption is currently linked to metabolic disorders including insulin resistance and dyslipidemia as well as hepatic steatosis. Dimethyl dimethoxy biphenyl dicarboxylate (DDB) is a hepatoprotectant with antioxidant and anti-inflammatory properties. The aim of this study therefore is to evaluate the effect of DDB on high fructose-induced metabolic disturbances and hepatic steatosis in a rat model. Male Wistar rats were allocated into three groups: control, fructose-fed (10% in drinking water and 10% in diet), and fructose-fed DDB (300 mg/kg, orally)-treated groups. Rats were fed a high-fructose diet for 6 weeks, while DDB was administered for an additional 2 weeks. High-fructose consumption elevated serum glucose and insulin levels and impaired oral glucose tolerance test, revealing insulin resistance. It also increased serum triglycerides and alanine aminotransferase as well as visceral fat content and decreased serum high-density lipoprotein. Additionally, histopathological examination revealed that high fructose intake induced hepatic steatosis. These alterations were associated with increased serum uric acid as well as hepatic content of malondialdehyde and nitric oxide (NO) in addition to overexpression of inducible NO synthase (iNOS). DDB administration significantly ameliorated the high fructose-induced hepatic and metabolic alterations. In conclusion, DDB ameliorates high fructose-induced metabolic disorders and hepatic steatosis in rats. Such protection is, at least in part, due to the inhibition of lipid peroxidation, decrease in iNOS overexpression, and reduction of elevated uric acid.
C1 [Morsy, Mohamed A.] King Faisal Univ, Div Pharmacol, Dept Pharmaceut Sci, Coll Clin Pharm, Al Hasa 31982, Saudi Arabia.
   [Morsy, Mohamed A.; Ibrahim, Mohamed A.] Menia Univ, Dept Pharmacol, Fac Med, El Minia, Egypt.
   [Abd-Elghany, Manal I.] Menia Univ, Dept Pathol, Fac Med, El Minia, Egypt.
C3 King Faisal University; Egyptian Knowledge Bank (EKB); Minia University;
   Egyptian Knowledge Bank (EKB); Minia University
RP Morsy, MA (corresponding author), King Faisal Univ, Coll Clin Pharm, Dept Pharmaceut Sci, Div Pharmacol, Al Hasa 31982, Saudi Arabia.
EM momorsy@kfu.edu.sa
RI ; Morsy, Mohamed/G-4809-2010
OI Ibrahim, Mohamed/0000-0002-3203-944X; Morsy, Mohamed/0000-0002-6752-9094
FU Deanship of Scientific Research, King Faisal University, Saudi Arabia
FX This study was supported in part by Deanship of Scientific Research,
   King Faisal University, Saudi Arabia.
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NR 29
TC 6
Z9 6
U1 0
U2 2
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0748-2337
EI 1477-0393
J9 TOXICOL IND HEALTH
JI Toxicol. Ind. Health
PD JAN
PY 2016
VL 32
IS 1
BP 59
EP 67
DI 10.1177/0748233713498445
PG 9
WC Public, Environmental & Occupational Health; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health; Toxicology
GA DA1UE
UT WOS:000367580200008
PM 24021431
DA 2025-06-11
ER

PT J
AU Sartang, MM
   Mazloomi, SM
   Tanideh, N
   Zadeh, AR
AF Sartang, Mohsen Mohammadi
   Mazloomi, Seyed Mohammad
   Tanideh, Nader
   Zadeh, Abbas Rezaian
TI The Effects of Probiotic Soymilk Fortified with Omega-3 on Blood
   Glucose, Lipid Profile, Haematological and Oxidative Stress, and
   Inflammatory Parameters in Streptozotocin Nicotinamide-Induced Diabetic
   Rats
SO JOURNAL OF DIABETES RESEARCH
LA English
DT Article
ID ANTIOXIDANT ENZYME-ACTIVITIES; CARDIOVASCULAR RISK-FACTORS; N-3
   FATTY-ACIDS; SOY PROTEIN; DOCOSAHEXAENOIC ACID; POSTMENOPAUSAL WOMEN;
   METABOLIC SYNDROME; FISH; ISOFLAVONE; PEROXIDATION
AB Objective. The aim of the present study was to evaluate the effects of probiotic soymilk fortified with omega-3 in diabetic rats. Methods. Soymilk (SM), fermented soymilk (FSM), and fermented soymilk fortified with omega-3 (FSM+ omega-3) were prepared. Rats were randomly assigned to five groups of 13 animals per group. Diabetes was induced by a single injection of streptozotocin (STZ) 15 min after the intraperitoneal administration of nicotinamide (NA). Normal control (NC) and diabetic control (DC) rats received 1 mL/day of distilled water and three groups of diabetic rats were given 1 mL/day of SM, FSM, and FSM+ omega-3 products by oral gavage for 28 days. Results. Three products significantly (P < 0.05) reduced blood glucose, total cholesterol (TC), triglyceride (TG), and malondialdehyde (MDA) concentrations compared to the DC group, with the maximum reduction seen in the FSM + omega-3 group. Body weight, red blood cells (RBC), haemoglobin (Hb), haematocrit, and superoxide dismutase (SOD) also significantly increased in the FSM + omega-3 group. In the FSM + omega-3 group, MDA level compared with the SM and FSM groups and high sensitivity C-reactive protein (hs-CRP) concentrations compared with the DC and FSM groups were significantly lower (P < 0.05). Conclusion. Fermented soymilk fortified with omega-3 may be beneficial in diabetes.
C1 [Sartang, Mohsen Mohammadi] Shiraz Univ Med Sci, Sch Nutr & Food Sci, Student Res Comm, Shiraz 7153675541, Iran.
   [Mazloomi, Seyed Mohammad] Shiraz Univ Med Sci, Sch Nutr & Food Sci, Nutr & Food Sci Res Ctr, Dept Food Hyg & Qual Control, Shiraz 7153675541, Iran.
   [Tanideh, Nader] Shiraz Univ Med Sci, Stem Cell & Transgen Technol Res Ctr, Dept Pharmacol, Sch Med, Shiraz 7134874478, Iran.
   [Zadeh, Abbas Rezaian] Shiraz Univ Med Sci, Sch Hlth, Dept Epidemiol, Res Ctr Hlth Sci, Shiraz 7153675541, Iran.
C3 Shiraz University of Medical Science; Shiraz University of Medical
   Science; Shiraz University of Medical Science; Shiraz University of
   Medical Science
RP Mazloomi, SM (corresponding author), Shiraz Univ Med Sci, Sch Nutr & Food Sci, Nutr & Food Sci Res Ctr, Dept Food Hyg & Qual Control, Shiraz 7153675541, Iran.
EM mazloomi@sums.ac.ir
RI Tanideh, Nader/M-3336-2013; Mazloomi, Seyed/K-1625-2013
OI Mazloomi, Seyed Mohammad/0000-0002-9672-7743
FU animal laboratory (Shiraz University of Medical Sciences)
FX The authors wish to thank the staff of the animal laboratory (Shiraz
   University of Medical Sciences) and the Research Deputy for the
   financial support provided to this research. They are also grateful to
   Mr. Iman Hosseini, Mrs. Samaneh Rahmdel, and Donia Firoozi for their
   assistance in this project.
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TC 30
Z9 31
U1 0
U2 20
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2314-6745
EI 2314-6753
J9 J DIABETES RES
JI J. Diabetes Res.
PY 2015
VL 2015
AR 696372
DI 10.1155/2015/696372
PG 9
WC Endocrinology & Metabolism; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Research & Experimental Medicine
GA CQ2XG
UT WOS:000360465100001
PM 26347893
OA Green Submitted, gold, Green Published
DA 2025-06-11
ER

PT J
AU Sciarretta, S
   Volpe, M
   Sadoshima, J
AF Sciarretta, Sebastiano
   Volpe, Massimo
   Sadoshima, Junichi
TI Mammalian Target of Rapamycin Signaling in Cardiac Physiology and
   Disease
SO CIRCULATION RESEARCH
LA English
DT Review
DE autophagy; heart; hypertrophy; ischemia; metabolism; mechanistic target
   of rapamycin complex 1; sirolimus
ID ISCHEMIA-REPERFUSION INJURY; DIET-INDUCED OBESITY; ACTIVATED
   PROTEIN-KINASE; RICTOR-MTOR COMPLEX; METABOLIC SYNDROME; LIFE-SPAN;
   PATHOLOGICAL HYPERTROPHY; MYOCARDIAL-INFARCTION; INSULIN-RESISTANCE;
   HEART-FAILURE
AB The protein kinase mammalian or mechanistic target of rapamycin (mTOR) is an atypical serine/threonine kinase that exerts its main cellular functions by interacting with specific adaptor proteins to form 2 different multiprotein complexes, mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2). mTORC1 regulates protein synthesis, cell growth and proliferation, autophagy, cell metabolism, and stress responses, whereas mTORC2 seems to regulate cell survival and polarity. The mTOR pathway plays a key regulatory function in cardiovascular physiology and pathology. However, the majority of information available about mTOR function in the cardiovascular system is related to the role of mTORC1 in the unstressed and stressed heart. mTORC1 is required for embryonic cardiovascular development and for postnatal maintenance of cardiac structure and function. In addition, mTORC1 is necessary for cardiac adaptation to pressure overload and development of compensatory hypertrophy. However, partial and selective pharmacological and genetic inhibition of mTORC1 was shown to extend life span in mammals, reduce pathological hypertrophy and heart failure caused by increased load or genetic cardiomyopathies, reduce myocardial damage after acute and chronic myocardial infarction, and reduce cardiac derangements caused by metabolic disorders. The optimal therapeutic strategy to target mTORC1 and increase cardioprotection is under intense investigation. This article reviews the information available regarding the effects exerted by mTOR signaling in cardiovascular physiology and pathological states.
C1 [Sciarretta, Sebastiano; Sadoshima, Junichi] Rutgers State Univ, New Jersey Med Sch, Dept Cell Biol & Mol Med, Cardiovasc Res Inst, Newark, NJ 07103 USA.
   [Sciarretta, Sebastiano; Volpe, Massimo] IRCCS Neuromed, Pozzilli, Italy.
   [Volpe, Massimo] Univ Roma La Sapienza, Fac Med & Psychol, Dept Clin & Mol Med, Div Cardiol, I-00185 Rome, Italy.
C3 Rutgers University System; Rutgers University New Brunswick; Rutgers
   University Biomedical & Health Sciences; Rutgers University Newark;
   IRCCS Neuromed; Sapienza University Rome
RP Sadoshima, J (corresponding author), Rutgers State Univ, New Jersey Med Sch, Dept Cell Biol & Mol Med, 185 South Orange Ave,Med Sci Bldg G-609, Newark, NJ 07103 USA.
EM sadoshju@njms.rutgers.edu
RI Volpe, Massimo/K-5240-2016; Sciarretta, Sebastiano/K-5161-2016
OI Sadoshima, Junichi/0000-0003-3724-4132; Sciarretta,
   Sebastiano/0000-0002-8633-6896; Volpe, Massimo/0000-0002-9642-8380
FU US Public Health Service [HL102738, HL67724, HL69020, HL91469, AG23039,
   AG27211]; Foundation Leducq Transatlantic Networks of Excellence;
   Italian Society of Hypertension; Italian Society of Cardiology; Founders
   Affiliate, American Heart Association
FX This work was supported in part by US Public Health Service grants
   (HL102738, HL67724, HL69020, HL91469, AG23039, and AG27211). This work
   was also supported by the Foundation Leducq Transatlantic Networks of
   Excellence. S. S. received support from a Postdoctoral Fellowship from
   the Founders Affiliate, American Heart Association, and a grant from the
   Italian Society of Hypertension and from the Italian Society of
   Cardiology.
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NR 137
TC 364
Z9 398
U1 3
U2 60
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0009-7330
EI 1524-4571
J9 CIRC RES
JI Circ.Res.
PD JAN 31
PY 2014
VL 114
IS 3
BP 549
EP 564
DI 10.1161/CIRCRESAHA.114.302022
PG 16
WC Cardiac & Cardiovascular Systems; Hematology; Peripheral Vascular
   Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Hematology
GA AG7GR
UT WOS:000335586800018
PM 24481845
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Kim, BJ
   Koh, JM
   Ahn, SH
   Lee, SH
   Kim, EH
   Bae, SJ
   Kim, HK
   Choe, JW
   Kim, GS
AF Kim, Beom-Jun
   Koh, Jung-Min
   Ahn, Seong Hee
   Lee, Seung Hun
   Kim, Eun Hee
   Bae, Sung Jin
   Kim, Hong-Kyu
   Choe, Jae Won
   Kim, Ghi Su
TI High Serum Total Bilirubin as a Protective Factor Against Hip Bone Loss
   in Healthy Middle-Aged Men
SO CALCIFIED TISSUE INTERNATIONAL
LA English
DT Article
DE Bilirubin; Bone loss; Antioxidant; Bone density
ID PRIMARY BILIARY-CIRRHOSIS; MINERAL DENSITY-MEASUREMENTS; METABOLIC
   SYNDROME; OSTEOPOROSIS; DISEASE; WOMEN; LEVEL; RISK
AB Bilirubin is known to have a physiologic role as an antioxidant that efficiently scavenges peroxyl radicals and suppresses oxidation, and oxidative stress has detrimental effects on bone metabolism. In the present study, we performed a 3-year longitudinal study of healthy middle-aged men, investigating the association between serum total bilirubin concentrations and annualized changes in bone mineral density (BMD). The study enrolled a total of 917 Korean men aged 40 years or older who had undergone comprehensive routine health examinations with an average follow-up interval of 3 years. BMD at proximal femur sites was measured with dual-energy X-ray absorptiometry using the same equipment at baseline and follow-up. The overall mean annualized rates of bone loss at the total femur, femoral neck, and trochanter were -0.25 %/year, -0.34 %/year, and -0.44 %/year, respectively. After adjustment for potential confounders, the rates of bone loss at all proximal femur sites were significantly attenuated in a dose-response fashion across increasing bilirubin concentrations (P = 0.006-0.046). Moreover, compared to subjects in the lowest bilirubin quartile category, those in the highest bilirubin quartile category showed significantly less bone loss at all proximal femur sites after adjustment for confounding factors (P = 0.010-0.048). This study provides the first clinical evidence that serum total bilirubin could be a protective marker against future bone loss, especially in subjects without liver diseases.
C1 [Kim, Beom-Jun; Koh, Jung-Min; Ahn, Seong Hee; Lee, Seung Hun; Kim, Ghi Su] Univ Ulsan, Div Endocrinol & Metab, Asan Med Ctr, Coll Med, Seoul 138736, South Korea.
   [Kim, Eun Hee; Bae, Sung Jin; Kim, Hong-Kyu; Choe, Jae Won] Univ Ulsan, Hlth Promot Ctr, Asan Med Ctr, Coll Med, Seoul 138736, South Korea.
C3 University of Ulsan; Asan Medical Center; University of Ulsan; Asan
   Medical Center
RP Koh, JM (corresponding author), Univ Ulsan, Div Endocrinol & Metab, Asan Med Ctr, Coll Med, 388-1 Poongnap2 Dong, Seoul 138736, South Korea.
EM jmkoh@amc.seoul.kr
RI Kim, Seunghyun/AAA-3402-2022; Kim, Yong Won/AAA-2134-2022; Kim,
   Kyung/N-6095-2017; Kim, Eun-hee/KEI-6829-2024
OI Kim, Beom-Jun/0000-0001-8591-1759
FU Korea Health Technology RD Project [A110536]; National Project for
   Personalized Genomic Medicine, Ministry of Health & Welfare, Republic of
   Korea [A111218-GM03]
FX This study was supported by grants from the Korea Health Technology R&D
   Project and the National Project for Personalized Genomic Medicine,
   Ministry of Health & Welfare, Republic of Korea (projects A110536 and
   A111218-GM03, respectively).
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NR 27
TC 6
Z9 7
U1 0
U2 6
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0171-967X
J9 CALCIFIED TISSUE INT
JI Calcif. Tissue Int.
PD JUN
PY 2013
VL 92
IS 6
BP 501
EP 508
DI 10.1007/s00223-013-9705-y
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 145MX
UT WOS:000319021400002
PM 23404194
DA 2025-06-11
ER

PT J
AU Costa, RRS
   Villela, NR
   Souza, MDC
   Boa, BCS
   Cyrino, FZGA
   Silva, SV
   Lisboa, PC
   Moura, EG
   Barja-Fidalgo, TC
   Bouskela, E
AF Costa, Rute R. S.
   Villela, Nivaldo Ribeiro
   Souza, Maria das Gracas C.
   Boa, Beatriz C. S.
   Cyrino, Fatima Z. G. A.
   Silva, Simone V.
   Lisboa, Patricia C.
   Moura, Egberto G.
   Barja-Fidalgo, Thereza Christina
   Bouskela, Eliete
TI High fat diet induces central obesity, insulin resistance and
   microvascular dysfunction in hamsters
SO MICROVASCULAR RESEARCH
LA English
DT Article
ID NITRIC-OXIDE SYNTHESIS; ENDOTHELIAL DYSFUNCTION; ADIPOSE-TISSUE;
   METABOLIC SYNDROME; CAPILLARY RECRUITMENT; DIABETES-MELLITUS; OXIDATIVE
   STRESS; HYPERTENSIVE-RAT; ANGIOTENSIN-II; WEIGHT-LOSS
AB Microvascular dysfunction is an early finding in obesity possibly related to co-morbidities like diabetes and hypertension. Therefore we have investigated changes on microvascular function, body composition, glucose and insulin tolerance tests (GTT and ITT) on male hamsters fed either with high fat (HFD, n = 20) or standard (Control, n = 21) diet during 16 weeks. Total body fat and protein content were determined by carcass analysis, aorta eNOS and iNOS expression by immunoblotting assay and mean blood pressure (MAP) and heart rate (HR) by an arterial catheter. Microvascular reactivity in response to acetylcholine and sodium nitroprusside, functional capillary density (FCD), capillary recruitment induced by a hyperinsulinemic status and macromolecular permeability after 30 min ischemia was assessed on either cheek pouch or cremaster muscle preparations. Compared to Control, HFD animals have shown increased visceral fat (6.0 +/- 0.8 vs. 13.8 +/- 0.6 g/100 g BW), impaired endothelial dependent vasodilatation, decreased FCD (11.3 +/- 1.3 vs. 6.8 +/- 12/field) and capillary recruitment during hyperinsulinemia and increased macromolecular permeability after ischemia/reperfusion (86.4 +/- 5.2 vs.105.2 +/- 5.1leaks/cm(2)), iNOS expression and insulin resistance. MAP, HR, endothelial independent vasodilatation and eNOS expression were not different between groups. Our results have shown that HFD elicits an increase on visceral fat deposition, microvascular dysfunction and insulin resistance in hamsters. (C) 2011 Elsevier Inc. All rights reserved.
C1 [Costa, Rute R. S.; Villela, Nivaldo Ribeiro; Souza, Maria das Gracas C.; Boa, Beatriz C. S.; Cyrino, Fatima Z. G. A.; Bouskela, Eliete] Univ Estado Rio De Janeiro, Lab Clin & Expt Res Vasc Biol BioVasc, BR-20550013 Rio De Janeiro, Brazil.
   [Villela, Nivaldo Ribeiro] Univ Fed Rio de Janeiro, HUCFF Anesthesiol Serv, Rio De Janeiro, Brazil.
   [Silva, Simone V.; Barja-Fidalgo, Thereza Christina] Univ Estado Rio De Janeiro, Dept Pharmacol & Psychobiol, BR-20550013 Rio De Janeiro, Brazil.
   [Lisboa, Patricia C.; Moura, Egberto G.] Univ Estado Rio De Janeiro, Dept Physiol Sci, BR-20550013 Rio De Janeiro, Brazil.
C3 Universidade do Estado do Rio de Janeiro; Universidade Federal do Rio de
   Janeiro; Universidade do Estado do Rio de Janeiro; Universidade do
   Estado do Rio de Janeiro
RP Villela, NR (corresponding author), Univ Estado Rio De Janeiro, Lab Clin & Expt Res Vasc Biol BioVasc, Rua Sao Francisco Xavier 524, BR-20550013 Rio De Janeiro, Brazil.
EM nivaldovillela@terra.com.br
RI Costa, Rute/ABE-5198-2021; BOA, BEATRIZ/D-1158-2013; Vargas da Silva,
   Simone/ABF-3471-2022; Moura, Egberto/H-1270-2012; Lisboa,
   Patricia/H-8336-2015
OI Moura, Egberto/0000-0002-1159-7549; Lisboa, Patricia/0000-0002-2477-4364
FU National Research Council of Brazil (CNPq); Foundation to Support
   Research in the Rio de Janeiro State (FAPERJ)
FX This work was supported by the National Research Council of Brazil
   (CNPq) and the Foundation to Support Research in the Rio de Janeiro
   State (FAPERJ).
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NR 51
TC 40
Z9 44
U1 0
U2 11
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0026-2862
EI 1095-9319
J9 MICROVASC RES
JI Microvasc. Res.
PD NOV
PY 2011
VL 82
IS 3
BP 416
EP 422
DI 10.1016/j.mvr.2011.08.007
PG 7
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 850FE
UT WOS:000297179700033
PM 21889944
OA hybrid
DA 2025-06-11
ER

PT J
AU Vieira, VJ
   Hu, L
   Valentine, RJ
   McAuley, E
   Evans, EM
   Baynard, T
   Woods, JA
AF Vieira, V. J.
   Hu, L.
   Valentine, R. J.
   McAuley, E.
   Evans, E. M.
   Baynard, T.
   Woods, J. A.
TI Reduction in trunk fat predicts cardiovascular exercise training-related
   reductions in C-reactive protein
SO BRAIN BEHAVIOR AND IMMUNITY
LA English
DT Article
DE Exercise; Aging; Stress; Inflammation; Psychosocial
ID GENDER-DIFFERENCES; HEART-DISEASE; RISK-FACTORS; WEIGHT-LOSS;
   PSYCHOSOCIAL FACTORS; CHRONIC INFLAMMATION; METABOLIC SYNDROME;
   PHYSICAL-FITNESS; AEROBIC EXERCISE; OLDER
AB C-reactive protein (CRP) is an independent risk factor for cardiovascular disease. We sought to determine (1) if 10 months of cardiovascular exercise training (Cardio) reduces CRP in a group of older adults, (2) if such a reduction is related to improvements in trunk fat, fitness, and/or psychosocial variables, and (3) if the effect of Cardio on CRP differs between men and women.
   Community-dwelling residents (n = 127; 60-83 yrs) were randomized to a Flex group (n = 61) where they participated in 2-75 min supervised sessions per wk during which they performed non-cardiovascular flexibility and balance exercises or a Cardio group (n = 66) where they participated in three supervised sessions per wk during which they performed cardiovascular exercises for similar to 45-60 min at 60-70% maximal oxygen uptake. The main outcome measures were serum CRP, cardiovascular fitness, total and central adiposity, and self-reported psychosocial function. Cardio experienced a reduction in CRP (-0.5 mg/L), as well as improvements in fitness (+7%) and total (-1.5%) and central (i.e., trunk) (-2.5%) adiposity. These relationships were not modified by sex. Regression analyses indicated that only the reduction in trunk fat was significantly related to the reduction in CRP.
   Ten months of cardiovascular exercise training reduced CRP in previously sedentary older adults and this effect was partially mediated by a reduction in trunk fat. (C) 2009 Elsevier Inc. All rights reserved.
C1 [Vieira, V. J.; Hu, L.; Valentine, R. J.; McAuley, E.; Evans, E. M.; Baynard, T.; Woods, J. A.] Univ Illinois, Dept Kinesiol & Community Hlth, Urbana, IL 61801 USA.
   [Vieira, V. J.; Evans, E. M.; Woods, J. A.] Univ Illinois, Div Nutr Sci, Urbana, IL 61801 USA.
   [Vieira, V. J.; Woods, J. A.] Univ Illinois, Integrat Immunol & Behav Program, Urbana, IL 61801 USA.
C3 University of Illinois System; University of Illinois Urbana-Champaign;
   University of Illinois System; University of Illinois Urbana-Champaign;
   University of Illinois System; University of Illinois Urbana-Champaign
RP Woods, JA (corresponding author), Univ Illinois, Dept Kinesiol & Community Hlth, 906 S Goodwin Ave,MC 052, Urbana, IL 61801 USA.
EM woods1@illinois.edu
RI Baynard, Tracy/AAN-8711-2021; McAuley, Edward/A-9508-2008
OI Baynard, Tracy/0000-0002-5150-4095
FU NIH [RO1 AG-18861]
FX NIH RO1 AG-18861 (to J.A. Woods).
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NR 49
TC 42
Z9 48
U1 0
U2 2
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0889-1591
EI 1090-2139
J9 BRAIN BEHAV IMMUN
JI Brain Behav. Immun.
PD MAY
PY 2009
VL 23
IS 4
BP 485
EP 491
DI 10.1016/j.bbi.2009.01.011
PG 7
WC Immunology; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Neurosciences & Neurology; Psychiatry
GA 433XT
UT WOS:000265239800012
PM 19486651
DA 2025-06-11
ER

PT J
AU Wu, GY
   Meininger, CJ
AF Wu, Guoyao
   Meininger, Cynthia J.
TI Nitric oxide and vascular insulin resistance
SO BIOFACTORS
LA English
DT Article
DE Arginine; nitric oxide; insulin; vascular function
ID CORONARY ENDOTHELIAL-CELLS; DIABETIC FATTY RATS; L-ARGININE;
   SKELETAL-MUSCLE; TETRAHYDROBIOPTERIN DEFICIENCY; METABOLIC SYNDROME;
   OXIDATIVE STRESS; REGULATORY ROLE; NO PRODUCTION; BLOOD-FLOW
AB Obesity and typeII diabetes are growing major health issues worldwide. They are the leading risk factors for vascular insulin resistance, which plays an important role in the pathogenesis of cardiovascular disease, the leading cause of death in developed nations. Recent studies have shown that reduced synthesis of nitric oxide (NO; a major vasodilator) from L-arginine in endothelial cells is a major factor contributing to the impaired action of insulin in the vasculature of obese and diabetic subjects. The decreased NO generation results from a deficiency of (6R)-5,6,7,8-tetrahydrobiopterin [BH4; an essential cofactor for NO synthase (NOS)], as well as increased generation of glucosamine (an inhibitor of the pentose cycle for the production of NADPH, another cofactor for NOS) from glucose and L-glutamine. Accordingly, endothelial dysfunction can be prevented by (1) enhancement of BH4 synthesis through supplementation of its precursor (sepiapterin) via the salvage pathway; (2) transfer of the gene for GTP cyclohydrolase-1 (the first and key regulatory enzyme for de novo synthesis of BH4); or (3) dietary supplementation Of L-arginine (which stimulates GTP cyclohydrolase-1 expression and inhibits hexosamine production). Modulation of the arginine-NO pathway by BH4 and arginine is beneficial for ameliorating vascular insulin resistance in obesity and diabetes. (C) 2009 International Union of Biochemistry and Molecular Biology, Inc. Volume 35, Number 1, January/February 2009, Pages 21-27. E-mail: g-wu@tamu.edu
C1 [Wu, Guoyao] Texas A&M Univ, Dept Anim Sci, College Stn, TX 77843 USA.
   [Wu, Guoyao] Texas A&M Univ, Fac Nutr, College Stn, TX 77843 USA.
   [Wu, Guoyao; Meininger, Cynthia J.] Texas A&M Hlth Sci Ctr, Dept Syst Biol & Translat Med, Coll Med, College Stn, TX USA.
   [Wu, Guoyao; Meininger, Cynthia J.] Texas A&M Hlth Sci Ctr, Cardiovasc Res Inst, Coll Med, College Stn, TX USA.
C3 Texas A&M University System; Texas A&M University College Station; Texas
   A&M University System; Texas A&M University College Station; Texas A&M
   University System; Texas A&M University College Station; Texas A&M
   Health Science Center; Texas A&M University System; Texas A&M University
   College Station; Texas A&M Health Science Center
RP Wu, GY (corresponding author), Texas A&M Univ, Dept Anim Sci, College Stn, TX 77843 USA.
EM g-wu@tamu.edu
RI Meininger, Cynthia/D-2846-2014
OI Meininger, Cynthia/0000-0002-1314-5044
FU National Institutes of Health [R21-HL077401-01, 1R21 HD049449]; USDA
   Cooperative State Research, Education, and Extension Service
   [2008-35206-18764, 2008-35203-19120]; American Heart Association
   [0255878Y, 0655109Y, 0755024y]; American Heart Association (AHA)
   [0655109Y, 0755024Y, 0255878Y] Funding Source: American Heart
   Association (AHA)
FX This work was supported, in part, by grants from National Institutes of
   Health (R21-HL077401-01 and 1R21 HD049449), National Research Initiative
   Competitive Program (2008-35206-18764 and 2008-35203-19120) from the
   USDA Cooperative State Research, Education, and Extension Service, and
   American Heart Association (0255878Y, 0655109Y and 0755024y).
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NR 52
TC 137
Z9 159
U1 0
U2 9
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0951-6433
EI 1872-8081
J9 BIOFACTORS
JI Biofactors
PD JAN-FEB
PY 2009
VL 35
IS 1
BP 21
EP 27
DI 10.1002/biof.3
PG 7
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 453SS
UT WOS:000266632800005
PM 19319842
DA 2025-06-11
ER

PT J
AU Staiger, K
   Staiger, H
   Weigert, C
   Haas, C
   Häring, HU
   Kellerer, M
AF Staiger, Katrin
   Staiger, Harald
   Weigert, Cora
   Haas, Carina
   Haering, Hans-Ulrich
   Kellerer, Monika
TI Saturated, but not unsaturated, fatty acids induce apoptosis of human
   coronary artery endothelial cells via nuclear factor-κB activation
SO DIABETES
LA English
DT Article
ID MUSCLE-CELLS; PALMITATE; INSULIN; EXPRESSION; STRESS; ATHEROTHROMBOSIS;
   INTERLEUKIN-6; METABOLITES; INHIBITION; PATHWAYS
AB High nonesterified fatty acid (NEFA) concentrations, as observed in the metabolic syndrome, trigger apoptosis of human umbilical vein endothelial cells. Since endothelial apoptosis may contribute to atherothrombosis, we studied the apoptotic susceptibility of human coronary artery endothelial cells (HCAECs) toward selected NEFAs and the underlying mechanisms. HCAECs were treated with single or combined NEFAs. Apoptosis was quantified by flow cytometry, nuclear factor kappa B (NF kappa B) activation by electrophoretic mobility shift assay, and secreted cytokines by enzyme-linked immunosorbent assay. Treatment of HCAECs with saturated NEFAs (palmitate and stearate) increased apoptosis up to fivefold (P < 0.05; n = 4). Unsaturated NEFAs (palmitoleate, oleate, and linoleate) did not promote apoptosis but prevented stearate-induced apoptosis (P < 0.05; n = 4). Saturated NEFA-induced apoptosis neither depended on ceramide formation nor on oxidative NEFA catabolism. However, NEFA activation via acyl-CoA formation was essential. Stearate activated NF kappa B and linoleate impaired stearate-induced NF kappa B activation. Pharmacological inhibition of NF kappa B and inhibitor Of kappa B kinase (IKK) also blocked stearate-induced apoptosis. Finally, the saturated NEFA effect on NF kappa B was not attributable to NEFA-induced cytokine production. In conclusion, NEFAs display differential effects on HCAEC survival; saturated NEFAs (palmitate and stearate) are proapoptotic, and unsaturated NEFAs (palmitoleate, oleate, and linoleate) are antilipoapoptotic. Mechanistically, promotion of HCAEC apoptosis by saturated NEFA requires acyl-CoA formation, IKK, and NF kappa B activation.
C1 Univ Tubingen, Med Clin, Div Endocrinol Metab & Pathobiochem, Dept Internal Med, D-72076 Tubingen, Germany.
   Marienhosp Stuttgart, Clin Diabetol Endocrinol INtens Care Med Vasc Med, Ctr Internal Med 1, Stuttgart, Germany.
C3 Eberhard Karls University of Tubingen; St. Marien Hospital
RP Kellerer, M (corresponding author), Univ Tubingen, Med Clin, Div Endocrinol Metab & Pathobiochem, Dept Internal Med, Otfried Muller Str 10, D-72076 Tubingen, Germany.
EM monikakellerer@vinzenz.de
RI Staiger, Harald/N-5871-2014
OI Staiger, Harald/0000-0002-9507-5333
CR Ajuwon KM, 2005, J NUTR, V135, P1841, DOI 10.1093/jn/135.8.1841
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NR 35
TC 120
Z9 140
U1 0
U2 3
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0012-1797
EI 1939-327X
J9 DIABETES
JI Diabetes
PD NOV
PY 2006
VL 55
IS 11
BP 3121
EP 3126
DI 10.2337/db06-0188
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 104OA
UT WOS:000241966500024
PM 17065351
OA Bronze
DA 2025-06-11
ER

PT J
AU Schulze, A
   Kwast, S
   Pökel, C
   Busse, M
AF Schulze, Antina
   Kwast, Stefan
   Pokel, Christoph
   Busse, Martin
TI Assessment of the Relationship between Periodontitis and Cardiac
   Parameters in Patients with Early Chronic Heart Failure: A
   Cross-Sectional Study
SO JOURNAL OF FUNCTIONAL MORPHOLOGY AND KINESIOLOGY
LA English
DT Article
DE heart failure; periodontitis; troponin; NT-proBNP; exercise performance;
   incremental testing; oral health
ID C-REACTIVE PROTEIN; LEFT-VENTRICULAR MASS; CARDIOVASCULAR-DISEASE;
   MEDITERRANEAN DIET; METABOLIC SYNDROME; OXIDATIVE STRESS;
   ALPHA-TOCOPHEROL; BLOOD-PRESSURE; OBESITY; RISK
AB Periodontal disease (PD) is considered a risk factor for cardiovascular events. However, its relationship to chronic heart failure (CHF) is unclear. The aim was to compare cardiac and inflammatory parameters in CHF patients with (PG) versus without periodontitis (NPG). The following parameters were recorded in 58 patients: periodontal screening and recording (PSR), troponin T, NT-proBNP, C-reactive protein (CRP), interleukin-6 (IL-6), blood pressure, heart rate, ejection fraction (EF), ventricular systolic and diastolic function parameters, incremental test, and three questionnaires (Mediterranean Diet Adherence Screener, MEDAS; Oral Health Impact Profile, OHIP-14; Patient Health Questionnaire, PHQ). The serum levels of NT-proBNP and troponin T were significantly higher in the PG, and the left ventricular systolic and diastolic function parameters were significantly lower. The correlation analysis showed age as the only independent risk factor for periodontitis and cardiac biomarkers. No significant group differences were found in the MEDAS, OHIP-14, and PHQ scores, or in CRP, IL-6, and cardiocirculatory parameters. Overall, the BMI correlated significantly with the mean PSR and total cholesterol. The occurrence of increased PSR together with increased age and cardiac risk parameters does not exclude an association between periodontitis and CHF, though no positive correlation was calculated. Periodontitis may be a modifiable risk factor for CHF. Its treatment may help to control the inflammatory burden.
C1 [Schulze, Antina; Pokel, Christoph; Busse, Martin] Univ Leipzig, Gen Outpatient Clin Sports Med, D-04103 Leipzig, Germany.
   [Kwast, Stefan] Helios Hlth Inst GmbH, D-13125 Berlin, Germany.
C3 Leipzig University
RP Schulze, A (corresponding author), Univ Leipzig, Gen Outpatient Clin Sports Med, D-04103 Leipzig, Germany.
EM aschu@rz.uni-leipzig.de; stefan.kwast@helios-health-institute.com;
   christoph.poekel@uni-leipzig.de; drmartinbusse@gmail.com
OI Pokel, Christoph/0009-0006-0795-9072
FU Innovation Funds of the Common Federal Committee Germany
FX No Statement Available
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NR 98
TC 2
Z9 2
U1 4
U2 7
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2411-5142
J9 J FUNCT MORPHOL KIN
JI J Funct. Morphol. Kinesiol.
PD MAR
PY 2024
VL 9
IS 1
AR 52
DI 10.3390/jfmk9010052
PG 17
WC Sport Sciences
WE Emerging Sources Citation Index (ESCI)
SC Sport Sciences
GA MH3X8
UT WOS:001192705800001
PM 38535432
OA gold
DA 2025-06-11
ER

PT J
AU Obomsawin, A
   D'Amico, D
   Fiocco, AJ
AF Obomsawin, Anik
   D'Amico, Danielle
   Fiocco, Alexandra J.
TI The association between Mediterranean diet adherence and allostatic load
   in older adults
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE Allostatic load; Dietary pattern; Older adults; Mediterranean diet;
   Biological sex
ID CUMULATIVE BIOLOGICAL RISK; METABOLIC SYNDROME; CHRONIC STRESS; HEALTH;
   MACARTHUR; COMPONENTS; PATTERN; AGE
AB Allostatic load (AL) is a multisystemic index of biological wear and tear which is associated with poor health outcomes. In recent years, researchers have examined the association between dietary pattern intake and AL; however, no studies to date have examined the relationship between AL and consumption of a Mediterranean diet. Blood and urine samples were collected from 201 community-dwelling older adults who completed a Food Frequency Questionnaire (FFQ). A Mediterranean Diet Score (MDS) was calculated based on previous recommendations and a sex-based AL index was calculated using a count-based approach for 16 biomarkers associated with neuroendocrine, immune, cardiovascular, or metabolic function. It was hypothesized that a higher MDS would be associated with lower AL, and that this association would be particularly robust for the immune and metabolic subcomponents of the AL index. In support of the primary study hypotheses, generalized linear models revealed a significant inverse relationship between MDS and AL (ss = -0.03, P = 0.037). However, subcomponents of the AL model were not significantly associated with MDS. Exploratory sub-group analyses by sex suggested that the association between AL and MDS was more robust in male than in female participants. The current findings are interpreted with caution given the study design and sample characteristics. Nonetheless, these findings contribute to the literature supporting the Mediterranean diet as an important lifestyle behavior that may minimize AL, and therefore support healthy aging.
C1 [Obomsawin, Anik; D'Amico, Danielle; Fiocco, Alexandra J.] Toronto Metropolitan Univ, Inst Stress & Wellbeing Res, Dept Psychol, Toronto, ON, Canada.
   [Fiocco, Alexandra J.] Toronto Metropolitan Univ, Dept Psychol, 350 Victoria St, Toronto, ON M5B 2K3, Canada.
C3 Toronto Metropolitan University; Toronto Metropolitan University
RP Fiocco, AJ (corresponding author), Toronto Metropolitan Univ, Dept Psychol, 350 Victoria St, Toronto, ON M5B 2K3, Canada.
EM afiocco@ryerson.ca
RI D'Amico, Danielle/MSX-0103-2025
OI Obomsawin, Anik/0009-0000-8734-3652; D'Amico,
   Danielle/0000-0001-5345-2711
FU Toronto Metropolitan University Harry Rosen Research Grant; Social
   Sciences and Humanities Research Council of Canada (SSHRC)
FX Alexandra J. Fiocco is a member of Team 5 (Diet and Prevention) of the
   Canadian Consortium on Neurodegeneration in Aging (CCNA) . Anik
   Obomsawin and Danielle D?Amico are trainee members of Team 5 of CCNA.
   The CCNA is supported by a grant from the Canadian Institutes of Health
   Research (CIHR) with funding from several partners. This study is
   partially supported by a Toronto Metropolitan University Harry Rosen
   Research Grant. Anik Obomsawin and Danielle D'Amico are supported by the
   Social Sciences and Humanities Research Council of Canada (SSHRC) . We
   would like to thank the participants who contributed their time to this
   study. We would also like to acknowledge Dr. Vivian Huang, Laura Krieger
   and the research assistants who contributed to the collection of data.
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NR 41
TC 10
Z9 10
U1 0
U2 14
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
EI 1873-3360
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD SEP
PY 2022
VL 143
AR 105840
DI 10.1016/j.psyneuen.2022.105840
PG 7
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA 2N5VT
UT WOS:000818446900009
PM 35752058
DA 2025-06-11
ER

PT J
AU Soman, A
   Kallidukkil, MN
   Scaria, B
   Alkhathami, K
AF Soman, Ajith
   Kallidukkil, Muhammad Najeeb
   Scaria, Bibin
   Alkhathami, Khalid
TI Effectiveness of Retro Walking and Forward Walking Treadmill Training on
   Abdominal Adiposity in Untrained Young Adults-A Quasi-experimental Study
SO JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH
LA English
DT Article
DE Abdominal obesity; Backward walking; Body mass
ID EXERCISE CAPACITY; OBESITY; RESPONSES; WAIST
AB Introduction: Retro walking or backward walking is an exercise mode which incurs an increased metabolic cost and results in a greater cardiopulmonary demand when compared to forward walking, while placing a lower stress on the joints of the lower limb. Abdominal adiposity, a part of metabolic syndrome, is an early risk-factor for morbidity and mortality in adulthood.
   Aim: The study aims to compare the effect of retro walking treadmill training and that of forward walking treadmill training, as potential modifiers of general obesity and abdominal obesity in untrained young adults.
   Materials and Methods: In this quasi experimental study, 111 untrained young men/young males aged 18-25 who were students of a medical university in Kingdom of Saudi Arabia were recruited and allocated randomly into two groups. One group underwent retro walking treadmill training five times a week for six weeks, and the other group underwent forward walking treadmill training for the same period. Waist-Hip Ratio (WHR), Waist- Height Ratio (WHtR) and Body Mass Index (BMI) were measured before and after the six-week intervention and subjected to statistical analysis.
   Results: There was a significant reduction in WHR and WHtR in the participants of the retro walking program when compared to participants of forward walking program. The decrease in BMI was not statistically significant.
   Conclusion: A retro walking training program is more effective in reducing BMI, WHR and WHtR in untrained young adults as compared to a forward walking program.
C1 [Soman, Ajith; Kallidukkil, Muhammad Najeeb; Alkhathami, Khalid] Shaqra Univ, Dept Hlth Rehabil, Coll Appl Med Sci, Riyadh, Saudi Arabia.
   [Scaria, Bibin] Shaqra Univ, Dept Clin Lab Sci, Coll Appl Med Sci, Riyadh, Saudi Arabia.
C3 Shaqra University; Shaqra University
RP Soman, A (corresponding author), Shaqra Univ, Dept Hlth Rehabil, Coll Appl Med Sci, Riyadh, Saudi Arabia.
EM ajithsoman78@gmail.com
RI scaria, Bibin/AAE-3621-2021; Soman, Ajith/GQH-6622-2022; Alkhathami,
   Khalid/ABC-6655-2021
OI Soman, Ajith/0000-0001-9890-2552; Alkhathami, Khalid/0000-0002-7630-5471
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NR 25
TC 1
Z9 2
U1 0
U2 4
PU PREMCHAND SHANTIDEVI RESEARCH FOUNDATION
PI DELHI
PA 71 JAIN COLONY, VEER NAGAR, DELHI, 110 007, INDIA
SN 2249-782X
EI 0973-709X
J9 J CLIN DIAGN RES
JI J. Clin. Diagn. Res.
PD MAY
PY 2021
VL 15
IS 5
DI 10.7860/JCDR/2021/46670.14853
PG 4
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA SH2UP
UT WOS:000653991300017
OA gold
DA 2025-06-11
ER

PT J
AU Youk, H
   Kim, M
   Lee, CJ
   Oh, J
   Park, S
   Kang, SM
   Kim, JH
   Ann, SJ
   Lee, SH
AF Youk, Harin
   Kim, Miso
   Lee, Chan Joo
   Oh, Jaewon
   Park, Sungha
   Kang, Seok-Min
   Kim, Jeong-Ho
   Ann, Soo-jin
   Lee, Sang-Hak
TI Nlrp3, Csf3, and Edn1 in Macrophage Response to
   Saturated Fatty Acids and Modified Low-Density Lipoprotein
SO KOREAN CIRCULATION JOURNAL
LA English
DT Article
DE Atherosclerosis; Metabolic syndrome; Immunity; Obesity
ID INFLAMMASOME; MECHANISM; TLR
AB Background and Objectives: The relationship between metabolic stress, inflammation, and cardiovascular disease is being studied steadily. The aim of this study was to evaluate the effect of palmitate (PA) and minimally modified low-density lipoprotein (mmLDL) on macrophages and to identify the associated pathways.
   Methods: J774 macrophages were incubated with PA or mmLDL and lipopolysaccharide (LPS). Secretion of inflammatory chemokines and the expression of corresponding genes were determined. The phosphorylation of extracellular signal-regulated kinase (ERK) mitogen-activated protein kinase was also assessed. RNA sequencing of macrophages was performed to identify the genes regulated by PA or mmLDL. Some of the genes regulated by the 2 agents were validated by knocking down the cells using small interfering RNA.
   Results: PA or mmLDL promoted the secretion of interleukin (IL)-6 and IL-1 beta in LPS-stimulated macrophages, and this was accompanied by higher phosphorylation of ERK. RNA sequencing revealed dozens of genes that were regulated in this process, such as Csf3and Edn1, which were affected by PA and mmLDL, respectively. These agents also increased NIrp3 expression. The effect of Csf3 or Edn1 silencing on inflammation was modest, whereas toll-like receptor (TLR) 4 inhibition reduced a large proportion of macrophage activation.
   Conclusions: We demonstrated that the proinflammatory milieu with high levels of PA or mmLDL promoted macrophage activation and the expression of associated genes such as NIrp3, 613, and Edn1. Although the TLR4 pathway appeared to be most relevant, additional role of other genes in this process provided insights regarding the potential targets for intervention.
C1 [Youk, Harin; Kim, Miso; Ann, Soo-jin] Yonsei Univ, Grad Program Sci Aging, Grad Sch, Seoul, South Korea.
   [Lee, Chan Joo; Oh, Jaewon; Park, Sungha; Kang, Seok-Min; Lee, Sang-Hak] Yonsei Univ, Severance Hosp, Dept Internal Med, Div Cardiol,Coll Med, 50-1 Yonsei Ro, Seoul 03722, South Korea.
   [Kim, Jeong-Ho] Yonsei Univ, Dept Lab Med, Coll Med, Seoul, South Korea.
C3 Yonsei University; Yonsei University; Yonsei University Health System;
   Yonsei University; Yonsei University Health System
RP Lee, SH (corresponding author), Yonsei Univ, Severance Hosp, Dept Internal Med, Div Cardiol,Coll Med, 50-1 Yonsei Ro, Seoul 03722, South Korea.; Ann, SJ (corresponding author), Yonsei Univ, Coll Med, Integrat Res Ctr Cerebrovasc & Cardiovasc Dis, 50-1 Yonsei Ro, Seoul 03722, South Korea.
EM hoppum@yuhs.ac; shl1106@yuhs.ac
RI Lee, Jeong Hoon/AAF-2400-2020; CHIA, YOOK CHIN/B-8379-2010; Kim,
   Jeong-Ho/A-7641-2018
OI Kang, Seok-Min/0000-0001-9856-9227; Kim, Jeong-Ho/0000-0003-2479-0548;
   Park, Sungha/0000-0001-5362-478X; Lee, Chan Joo/0000-0002-8756-409X; Oh,
   Jaewon/0000-0002-4585-1488
FU National Research Foundation of Korea - Korean government
   [20181D1A1B07043855, 2019R1F1A1057952]
FX This study was supported by the National Research Foundation of Korea,
   funded by the Korean government (No. 20181D1A1B07043855 and
   2019R1F1A1057952).
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NR 30
TC 8
Z9 8
U1 2
U2 7
PU KOREAN SOC CARDIOLOGY
PI SEOUL
PA 101-1704, LOTTE CASTLE PRESIDENT, 109, MAPO-DAERO, MAPO-GU, SEOUL,
   04146, SOUTH KOREA
SN 1738-5520
EI 1738-5555
J9 KOREAN CIRC J
JI Korean Circ. J.
PD JAN
PY 2021
VL 51
IS 1
BP 68
EP 80
DI 10.4070/kcj.2020.0117
PG 13
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA PN4VN
UT WOS:000604478600007
PM 32975056
OA Green Published
DA 2025-06-11
ER

PT J
AU Aminzadeh, Z
   Jamalan, M
   Chupani, L
   Lenjannezhadian, H
   Ghaffari, MA
   Aberomand, M
   Zeinali, M
AF Aminzadeh, Z.
   Jamalan, M.
   Chupani, L.
   Lenjannezhadian, H.
   Ghaffari, M. A.
   Aberomand, M.
   Zeinali, M.
TI In vitro reprotoxicity of carboxyl-functionalised single- and
   multi-walled carbon nanotubes on human spermatozoa
SO ANDROLOGIA
LA English
DT Article
DE carboxylated carbon nanotubes; human spermatozoa; motility; oxidative
   stress; viability
ID QUALITY-OF-LIFE; LATE-ONSET HYPOGONADISM; LOW TESTOSTERONE LEVELS;
   METABOLIC SYNDROME; OLDER MEN; ERECTILE DYSFUNCTION; PATIENT
   PERCEPTIONS; INSULIN-RESISTANCE; DOUBLE-BLIND; HEALTH
AB Reproductive toxicity of carboxyl-functionalised carbon nanotubes (CNT-COOH), as the most commonly used form of water-soluble CNTs, is not clearly studied. The aim of this study was to investigate in vitro toxicity of carboxylated single-walled and multi-walled CNTs (SWCNT-COOH and MWCNT-COOH) against human spermatozoa. Sperm cells from healthy donors were incubated with 0.1-100 mu g/ml of SWCNT-COOH or MWCNT-COOH at 37 degrees C for up to 5 hr. Viability of sperm cells was assessed using MTT test, and sperm motility was evaluated following World Health Organization guideline. Production of reactive oxygen species (ROS) and nitric oxide (NO) in sperm was also assessed. We showed that both MWCNT-COOH and SWCNT-COOH following incubation in vitro with human spermatozoa did not exert negative effect on viability while motility was significantly (p < .05) dropped in a dose-dependent manner. Moreover, there was no significant effect of the type, dose and exposure time of the CNT-COOH on NO production. Exposure of sperm cells to both examined types of CNTs at concentrations as low as 0.1 mu g/ml caused a significant increase in ROS levels. In conclusion, carboxylated forms of CNTs seem to be harmful for human spermatozoa. Further studies, especially using in vivo models, are needed to decide about reprotoxicity of carboxylated forms of CNTs.
C1 [Aminzadeh, Z.; Ghaffari, M. A.; Aberomand, M.] Ahvaz Jundishapur Univ Med Sci, Dept Clin Biochem, Cellular & Mol Res Ctr, Ahvaz, Iran.
   [Chupani, L.] Univ South Bohemia Ceske Budejovice, Fac Fisheries & Protect Waters, South Bohemian Res Ctr Aquaculture & Biodivers Hy, Res Inst Fish Culture & Hydrobiol, Vodnany, Czech Republic.
   [Lenjannezhadian, H.; Zeinali, M.] Res Inst Petr Ind RIPI, Biotechnol Res Ctr, Tehran, Iran.
   [Jamalan, M.] Abadan Sch Med Sci, Abadan, Iran.
C3 Ahvaz Jundishapur University of Medical Sciences (AJUMS); University of
   South Bohemia Ceske Budejovice
RP Zeinali, M (corresponding author), Res Inst Petr Ind RIPI, Biotechnol Res Ctr, Tehran, Iran.; Jamalan, M (corresponding author), Abadan Sch Med Sci, Abadan, Iran.
EM jamalan-m@ajums.ac.ir; zeinalim@ripi.ir
RI shokrgozar, mohammad/L-4149-2017; Chupani, Latifeh/G-4771-2015; Jamalan,
   Mostafa/AAQ-9105-2020; Aberomand, Mohammad/L-3837-2018; aminzadeh,
   zahra/C-2796-2008
OI Chupani, Latifeh/0000-0002-9001-5809; Aberomand,
   Mohammad/0000-0002-2784-1550; aminzadeh, zahra/0000-0002-5250-6922;
   helbi, sobhan/0000-0001-6207-648X
FU Cellular and Molecular Research Center [CMRC-129]
FX Cellular and Molecular Research Center, Grant/Award Number: CMRC-129.
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NR 38
TC 10
Z9 11
U1 0
U2 23
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0303-4569
EI 1439-0272
J9 ANDROLOGIA
JI Andrologia
PD NOV
PY 2017
VL 49
IS 9
AR e12741
DI 10.1111/and.12741
PG 8
WC Andrology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism
GA FJ6BI
UT WOS:000412838200003
PM 28000929
DA 2025-06-11
ER

PT J
AU Carey, RM
AF Carey, Robert M.
TI Update on angiotensin AT2 receptors
SO CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION
LA English
DT Review
DE angiotensin; angiotensin receptors; blood pressure; hypertension; kidney
   function; kidney protection; natriuresis; sodium excretion
ID OBESE ZUCKER RATS; II TYPE-2 RECEPTORS; SPONTANEOUSLY HYPERTENSIVE-RATS;
   BLOOD-PRESSURE; NITRIC-OXIDE; MICE LACKING; CARDIOVASCULAR-DISEASE;
   NATRIURESIS; AGONIST; AT(1)
AB Purpose of review
   This review updates major new findings and concepts introduced during the past year on the role of angiotensin II (Ang II) subtype 2 receptors (AT(2)Rs) in the control of blood pressure and renal function.
   Recent findings
   AT(2)R activation prevents sodium (Na+) retention and lowers blood pressure in the Ang II infusion model of experimental hypertension and prevents salt-sensitive hypertension in the obese Zucker rat model of obesity and the metabolic syndrome. Ang II metabolite, des-aspartyl(1)-Ang II (Ang III) is the predominant AT(2)R agonist in the kidney and possibly also in the vasculature; a novel synthetic Ang III peptide, beta-Pro-Ang III, is vasodepressor and lowers blood pressure in conscious spontaneously hypertensive rats in the presence of low-level Ang II type 1 receptor (AT1R) blockade. Because nitric oxide is a product of AT(2)R activation, a potential feed-forward loop, wherein nitric oxide increases AT(2)R transcription, may reinforce the beneficial actions of AT2R in the long term. AT(2)R activation also reduces proteinuria and oxidative stress in glomerulosclerotic kidneys of high-salt obese Zucker rats.
   Summary
   Studies during the past year have helped to clarify the physiological and pathophysiological roles of AT2Rs and have enhanced the promise of AT(2)R agonists in cardiovascular and renal disease.
C1 [Carey, Robert M.] Univ Virginia Hlth Syst, Div Endocrinol & Metab, Dept Med, Charlottesville, VA USA.
C3 University of Virginia; University of Virginia (UVA) Health System
RP Carey, RM (corresponding author), Univ Virginia Hlth Syst, POB 801414, Charlottesville, VA 22908 USA.
EM rmc4c@virginia.edu
FU National Institutes of Health [1-R01-HL-128189]
FX This review was supported by National Institutes of Health research
   grant 1-R01-HL-128189.
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NR 51
TC 42
Z9 44
U1 0
U2 9
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1062-4821
EI 1473-6543
J9 CURR OPIN NEPHROL HY
JI Curr. Opin. Nephrol. Hypertens.
PD MAR
PY 2017
VL 26
IS 2
BP 91
EP 96
DI 10.1097/MNH.0000000000000304
PG 6
WC Urology & Nephrology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology; Cardiovascular System & Cardiology
GA EK5KD
UT WOS:000393964400004
PM 27906747
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Mangge, H
   Weghuber, D
   Prassl, R
   Haara, A
   Schnedl, W
   Postolache, TT
   Fuchs, D
AF Mangge, Harald
   Weghuber, Daniel
   Prassl, Ruth
   Haara, Astrid
   Schnedl, Wolfgang
   Postolache, Teodor T.
   Fuchs, Dietmar
TI The Role of Vitamin D in Atherosclerosis Inflammation Revisited: More a
   Bystander than a Player?
SO CURRENT VASCULAR PHARMACOLOGY
LA English
DT Article
DE Atherosclerosis; cardiovascular disease; immune-mediated inflammation;
   therapeutic potential; vitamin-D
ID CALCIUM/VITAMIN-D SUPPLEMENTATION; 1,25-DIHYDROXYVITAMIN D-3;
   CARDIOVASCULAR-DISEASE; ENDOTHELIAL FUNCTION; METABOLIC SYNDROME;
   BLOOD-PRESSURE; D DEFICIENCY; NEOPTERIN; OBESITY; RISK
AB Levels of 25-hydroxy vitamin D [25(OH)D] are reported to be decreased in cardiovascular disease (CVD) and in other chronic immunopathologies. Vitamin D (vitD) has been shown to be significantly linked to mortality, and is thought to be a predictor of survival. Therefore, supplementation with vitD has been suggested as an option to improve clinical outcomes.
   In contrast to the causal assumption, we hypothesize that the decreased vitD levels, seen in patients with CVD and chronic immunopathologies is secondary to inflammation and not as pathophysiologically relevant as currently suggested. Under these conditions, low vitD might be mainly caused by oxidative stress that results from chronic, immune-mediated vascular and systemic inflammation seen in patients with CVD. The oxidative environment most likely causes biodegradation of vitD and interferes with key enzymes, disturbing the biosynthesis of 25(OH)D and 1,25(OH)D. Thus far, no clear evidence of a beneficial effect of vitD supplements exists, beyond treating vitD deficiency to improve skeletal health. Moreover, a prolonged and/or high dose vitD supplementation, unless needed to correct actual vitD deficiency [levels of 25(OH) D<20 ng/ml)] may even be immunologically harmful by downregulating Th1 immune responses and indirectly upregulating Th2 immune activation with potential detrimental metabolic and cardiovascular effects. Large randomized controlled studies of vitD with multiple outcomes (skeletal, metabolic, cardiovascular and mental) are urgently needed.
C1 [Mangge, Harald] Med Univ Graz, Clin Inst Med & Chem Lab Diag, A-8036 Graz, Austria.
   [Weghuber, Daniel] Paracelsus Private Med Sch Salzburg, Dept Pediat, Salzburg, Austria.
   [Prassl, Ruth] Med Univ Graz, Inst Biophys, A-8036 Graz, Austria.
   [Haara, Astrid; Fuchs, Dietmar] Med Univ Innsbruck, Bioctr, Div Biol Chem, A-6020 Innsbruck, Austria.
   [Postolache, Teodor T.] Univ Maryland, Sch Med, Dept Psychiat, Mood & Anxiety Program, Baltimore, MD 21201 USA.
C3 Medical University of Graz; Paracelsus Private Medical University;
   Medical University of Graz; Medical University of Innsbruck; University
   System of Maryland; University of Maryland Baltimore
RP Mangge, H (corresponding author), Med Univ Graz, Res Unit Lifestyle & Inflammat Associated Risk Bi, Clin Inst Med & Chem Lab Diag, Auenbruggerpl 30, A-8036 Graz, Austria.
EM harald.mangge@klinikum-graz.at
RI Prassl, Ruth/AAE-1523-2021; Fuchs, Dietmar/AAL-8011-2021; Weghuber,
   Daniel/AAN-1422-2020
OI Schnedl, Wolfgang/0000-0002-5212-5230; Mangge,
   Harald/0000-0003-4067-247X; Prassl, Ruth/0000-0002-1010-9494;
   Postolache, Teodor/0000-0001-6056-4244
FU European FP7 program "NanoAthero" [NMP4-LA-2012-3099820]
FX This work was supported by funding under the European FP7 program
   "NanoAthero" - NMP4-LA-2012-3099820.
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NR 84
TC 26
Z9 28
U1 0
U2 9
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1570-1611
EI 1875-6212
J9 CURR VASC PHARMACOL
JI Current Vascular Pharmacology
PY 2015
VL 13
IS 3
BP 392
EP 398
DI 10.2174/1570161111666131209125454
PG 7
WC Pharmacology & Pharmacy; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Cardiovascular System & Cardiology
GA CM4ZE
UT WOS:000357694900013
PM 24329737
DA 2025-06-11
ER

PT J
AU Ghosh, SK
   Raheja, S
   Tuli, A
   Raghunandan, C
   Agarwal, S
AF Ghosh, Sanjib Kumar
   Raheja, Shashi
   Tuli, Anita
   Raghunandan, Chitra
   Agarwal, Sneh
TI Serum placental growth factor as a predictor of early onset preeclampsia
   in overweight/obese pregnant women
SO JOURNAL OF THE AMERICAN SOCIETY OF HYPERTENSION
LA English
DT Article
DE Adipose tissue; inflammatory cytokines; reactive oxygen species;
   placental oxidative stress
ID UTERINE ARTERY DOPPLER; BODY-MASS INDEX; HYPERTENSIVE DISORDERS;
   METABOLIC SYNDROME; ANGIOGENIC FACTORS; ALPHA-TOCOPHEROL; RISK; OBESITY;
   MARKERS; PROTEIN
AB The purpose of this study was to analyze whether maternal serum placental growth factor (P1GF) could predict early onset preeclampsia (<32 weeks of gestation) in overweight/obese pregnant women, and whether it could do it more effectively than in normal/underweight pregnant women. A prospective cohort study was conducted on 1678 pregnant women with singleton pregnancies, who were grouped as underweight, normal', overweight, and obese on the basis of body mass index, followed by serum P1GF estimation at 20 to 22 weeks of gestation. A cut-off value of <144 pg/mL for P1GF was determined by Receiver Operating Characteristic curve analysis to identify risk of early onset preeclampsia. Univariate logistic regression analysis revealed significantly stronger association between P1GF <144 pg/mL and early onset preeclampsia in overweight/obese pregnant women (odds ratio 7.64; 95% confidence interval 5.34-10.12; P = .000) than in normal/underweight pregnant women (odds ratio 2.95; 95% confidence interval 1.74-4.26; P = .007). Weight and P1GF levels in study women had a significant negative correlation (r = 0.663; P = .002). Serum P1GF in early second trimester could be an effective predictor of early onset preeclampsia in overweight/obese pregnant women and may be more effective than in normal/underweight pregnant women. J Am Soc Hypertens 2013;7(2):137-148. (C) 2013 American Society of Hypertension. All rights reserved.
C1 [Ghosh, Sanjib Kumar; Raheja, Shashi; Tuli, Anita; Agarwal, Sneh] Lady Hardinge Med Coll & Hosp, Dept Anat, New Delhi 110001, India.
   [Ghosh, Sanjib Kumar; Raheja, Shashi; Tuli, Anita; Raghunandan, Chitra; Agarwal, Sneh] Smt Sucheta Kriplani Hosp, New Delhi 110001, India.
   [Raghunandan, Chitra] Lady Hardinge Med Coll & Hosp, Dept Obstet & Gynecol, New Delhi 110001, India.
C3 Lady Hardinge Medical College & Hospital; Lady Hardinge Medical College
   & Hospital; Lady Hardinge Medical College & Hospital
RP Ghosh, SK (corresponding author), Lady Hardinge Med Coll & Hosp, Dept Anat, Shaheed Bhagat Singh Marg, New Delhi 110001, India.
EM drsanjib79@gmail.com
RI GHOSH, SANJIB/B-6466-2019
OI GHOSH, SANJIB/0000-0002-7293-6735
FU Lady Hardinge Medical College, New Delhi, India
FX Supported by Lady Hardinge Medical College, New Delhi, India.
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NR 51
TC 21
Z9 22
U1 0
U2 7
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1933-1711
EI 1878-7436
J9 J AM SOC HYPERTENS
JI J. Am. Soc. Hypertens.
PD MAR-APR
PY 2013
VL 7
IS 2
BP 137
EP 148
DI 10.1016/j.jash.2012.12.006
PG 12
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 120KI
UT WOS:000317168800005
PM 23394804
DA 2025-06-11
ER

PT J
AU Vera, RH
   Vilahur, G
   Badimon, L
AF Hernandez Vera, Rodrigo
   Vilahur, Gemma
   Badimon, Lina
TI Obesity with insulin resistance increase thrombosis in wild-type and
   bone marrow-transplanted Zucker fatty rats
SO THROMBOSIS AND HAEMOSTASIS
LA English
DT Article
DE Obesity; thrombosis; bone marrow; insulin resistance
ID MEAN PLATELET VOLUME; METABOLIC SYNDROME; ADIPOSE-TISSUE;
   CARDIOVASCULAR-DISEASE; DIABETES-MELLITUS; VASCULAR-DISEASE;
   WEIGHT-LOSS; PHYSICAL-ACTIVITY; OXIDATIVE STRESS; HEART-DISEASE
AB Obesity induces metabolic and inflammatory alterations that contribute to the presentation of cardiovascular events. Although obesity is a risk factor for atherosclerosis and vascular disease, its role on thrombosis has not been directly explored. Therefore, we aimed to investigate the mechanisms by which obesity affects thrombosis. Thrombus formation was monitored by real-time intravital microscopy in Zucker Fatty rats (ZF) and lean controls (ZC). Crossed bone marrow (BM) transplants between ZF and ZC were performed. Intravital microscopy showed that ZF had significantly shorter occlusion times (OTs) than ZC, reflecting a three-fold higher thrombotic risk. Transplantation of ZC-BM to ZF recipients significantly reduced thrombosis, reducing their thrombotic risk to one third of that observed in non-transplanted ZF. Wild-type ZF showed increased platelet counts and increased platelet size compared to wild-type ZC and platelet number remained unaltered after transplantation. However, ZF-BM produced a significant increase in platelet size in ZC recipients. Thrombotic risk was found to be inversely correlated with both weight and insulin levels and directly correlated to HOMA-IR, while platelet number and size were directly correlated with weight. Thus, our data shows that obesity with insulin resistance significantly increases thrombosis and that alterations in BM-derived cells significantly contribute to this prothrombotic behaviour. Importantly, the reduction of insulin resistance was associated with reduced thrombotic risk even in the presence of obesity.
C1 [Hernandez Vera, Rodrigo; Vilahur, Gemma; Badimon, Lina] Hosp Santa Creu & St Pau UAB, Cardiovasc Res Ctr, CSIC ICCC, CIBERobn Pathophysiol Obes & Nutr, Barcelona, Spain.
   [Badimon, Lina] UAB, Cardiovasc Res Chair, Barcelona, Spain.
C3 Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Institut
   Catala de Ciencies Cardiovasculars (ICCC); CIBER - Centro de
   Investigacion Biomedica en Red; CIBEROBN; Autonomous University of
   Barcelona
RP Badimon, L (corresponding author), Cardiovasc Res Ctr, C St Antoni Maria Claret 167, Barcelona 08025, Spain.
EM lbadimon@csic-iccc.org
RI Vera, Rodrigo/KIJ-9518-2024; BADIMON, LINA/S-2950-2019; Badimon,
   Lina/O-4711-2014
OI Hernandez Vera, Rodrigo/0000-0002-4241-2113; Badimon,
   Lina/0000-0002-9162-2459
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NR 41
TC 17
Z9 17
U1 0
U2 6
PU SCHATTAUER GMBH-VERLAG MEDIZIN NATURWISSENSCHAFTEN
PI STUTTGART
PA HOLDERLINSTRASSE 3, D-70174 STUTTGART, GERMANY
SN 0340-6245
J9 THROMB HAEMOSTASIS
JI Thromb. Haemost.
PD FEB
PY 2013
VL 109
IS 2
BP 319
EP 327
DI 10.1160/TH12-09-0696
PG 9
WC Hematology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Hematology; Cardiovascular System & Cardiology
GA 087AV
UT WOS:000314734500021
PM 23238129
DA 2025-06-11
ER

PT J
AU Ogino, K
   Kato, M
   Furuse, Y
   Kinugasa, Y
   Kaetsu, Y
   Mizuta, E
   Sugihara, S
   Ishida, K
   Yanagihara, K
   Hisatome, I
   Shigemasa, C
AF Ogino, Kazuhide
   Kato, Masahiko
   Furuse, Yoshiyuki
   Kinugasa, Yoshiharu
   Kaetsu, Yasuhiro
   Mizuta, Einosuke
   Sugihara, Shinobu
   Ishida, Katsunori
   Yanagihara, Kiyotaka
   Hisatome, Ichiro
   Shigemasa, Chiaki
TI Addition of Losartan to Angiotensin-Converting Enzyme Inhibitors
   Improves Insulin Resistance in Patients With Chronic Heart Failure
   Treated Without β-Blockers
SO CIRCULATION JOURNAL
LA English
DT Article
DE Angiotensin; Cytokine; Heart failure; Inflammation; Insulin
ID SERUM URIC-ACID; RANDOMIZED CLINICAL-TRIALS; TYPE-2 DIABETES-MELLITUS;
   HIGH CARDIOVASCULAR RISK; NECROSIS-FACTOR-ALPHA; II RECEPTOR BLOCKER;
   HYPERTENSIVE PATIENTS; OXIDATIVE STRESS; METABOLIC SYNDROME; SIGNALING
   SYSTEMS
AB Background: Angiotensin II and insulin resistance (IR) have clinical implications in the pathophysiology of chronic heart failure (CHF). However, it is still unclear whether the combination of an angiotensin-receptor blocker and angiotensin-converting enzyme inhibitor (ACEI) improves IR in CHF patients who do not receive beta-blockers. Thus, the aim of the present study was to evaluate the effects of losartan on glucose metabolism and inflammatory cytokines in CHF patients treated with ACEI but not beta-blockers.
   Methods and Results: The effect of losartan treatment for 16 weeks on IR was analyzed in 16 CHF patients in a randomized crossover trial. Insulin level and homeostasis model IR index (HOMA-IR) decreased significantly (P<0.05), but fasting plasma glucose did not change significantly. Serum tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, and monocyte chemoattractant protein (MCP)-1 levels were significantly decreased with losartan (P<0.05). Furthermore, the changes in IL-6 and MCP-1 levels were significantly correlated with the reduction in HOMA-IR (P<0.05), but the change in TNF-alpha levels was not significantly correlated.
   Conclusions: The addition of losartan to ACEI therapy improved IR and decreased inflammatory cytokines in CHF patients who did not receive beta-blockers. (Circ J 2010; 74: 2346-2352)
C1 [Ogino, Kazuhide] Tottori Univ Hosp, Ctr Clin Residency Program, Yonago, Tottori 6838504, Japan.
   [Kato, Masahiko; Furuse, Yoshiyuki; Kinugasa, Yoshiharu; Kaetsu, Yasuhiro; Mizuta, Einosuke; Sugihara, Shinobu; Ishida, Katsunori; Yanagihara, Kiyotaka; Shigemasa, Chiaki] Tottori Univ, Fac Med, Dept Cardiovasc Med, Yonago, Tottori 683, Japan.
   [Hisatome, Ichiro] Tottori Univ, Dept Genet Med & Regenerat Therapeut, Grad Sch Med, Yonago, Tottori, Japan.
C3 Tottori University; Tottori University; Tottori University
RP Ogino, K (corresponding author), Tottori Univ Hosp, Ctr Clin Residency Program, 36-1 Nishimachi, Yonago, Tottori 6838504, Japan.
EM ko-36@umin.ac.jp
FU Japan Society for the Promotion of Science [20590826]; Tottori
   University Faculty of Medicine; Gout Research Foundation; Grants-in-Aid
   for Scientific Research [20590826] Funding Source: KAKEN
FX This research was financially supported by a grant-in-aid for scientific
   research from the Japan Society for the Promotion of Science (No.
   20590826 to K.O.), a grant-in-aid for scientific research from the
   Tottori University Faculty of Medicine (to K.O.), and the Gout Research
   Foundation (to K.O.).
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NR 53
TC 11
Z9 13
U1 0
U2 4
PU JAPANESE CIRCULATION SOC
PI KYOTO
PA KINKI INVENTION CENTER, 14 YOSHIDA KAWAHARACHO, SAKYO-KU, KYOTO,
   606-8305, JAPAN
SN 1346-9843
J9 CIRC J
JI Circ. J.
PD NOV
PY 2010
VL 74
IS 11
BP 2346
EP 2352
DI 10.1253/circj.CJ-10-0395
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 672YG
UT WOS:000283623200020
PM 20827028
OA Bronze
DA 2025-06-11
ER

PT J
AU Yi, YH
   Li, T
   Lv, CH
   He, WJ
   Li, WZ
   Zhou, XX
   Qin, S
AF Yi, Yuhang
   Li, Tao
   Lv, Chenghao
   He, Wenjiang
   Li, Wenzhi
   Zhou, Xixin
   Qin, Si
TI Proanthocyanidins isolated from lotus seed skin mitigate glycolipid
   metabolism disorder through the p38/Nrf2/NF-κB signaling pathway
SO ACTA BIOCHIMICA ET BIOPHYSICA SINICA
LA English
DT Article
DE proanthocyanidins; lotus seed skin; p38/Nrf2/NF-kappa B; glycolipid
   metabolism
ID A-TYPE PROCYANIDINS; OXIDATIVE STRESS; SKELETAL-MUSCLE; STREPTOZOTOCIN;
   EXTRACT; NRF2; INFLAMMATION; ACTIVATION; BLUEBERRY
AB Lotus seed skin extract is rich in flavonoids, making it a promising candidate for developing health products. In a previous study, we found that proanthocyanidins from lotus seed skin, particularly proanthocyanidin B1 (PB1), can indirectly activate the Nrf2 signaling pathway, exerting an antioxidant effect. In this study, we isolate proanthocyanidins from lotus seed skin (PLS) using ethanol extraction and RP-HPLC identification, and investigate its effects on glycolipid metabolism both in vivo and in vitro. Our results demonstrate that PLS reduces body weight in high-fat diet (HFD) mice by decreasing feed efficiency. PLS also normalizes serum glucose, insulin secretion, glycosylated hemoglobin (HbA1c), and intraperitoneal glucose tolerance (IPGTT). Furthermore, PLS significantly improves blood lipid parameters and inhibits the expressions of six proinflammatory factors, including IL-1 alpha, IL-1(3, IL-3, IL-6, IFN-gamma and TNF-alpha in HFD mice. Additionally, analysis of fresh liver tissues reveals that PLS and PB1 induce the expressions of antioxidant proteins such as HO-1 and NQO1 by activating the p38-Nrf2 signaling pathway and inhibiting the NF kappa B signaling pathway. In conclusion, proanthocyanidins from lotus seed skin regulate glycolipid metabolism disorders by targeting the p38/Nrf2/NF-kappa B signaling pathway. Our study offers a new approach for the high-value comprehensive utilization of lotus seed skin by-products and precise dietary intervention for metabolic syndrome.
C1 [Yi, Yuhang; Qin, Si] Hunan Agr Univ, Coll Food Sci & Technol, Changsha 410128, Peoples R China.
   [Li, Tao] Hunan Acad Agr Sci, Hunan Agr Prod Proc Inst, Changsha 410125, Peoples R China.
   [Lv, Chenghao; He, Wenjiang; Zhou, Xixin; Qin, Si] Hunan Agr Univ, Coll Biol Sci & Technol, Changsha 410128, Peoples R China.
   [He, Wenjiang; Li, Wenzhi] Infinitus China Co Ltd, Guangzhou 510665, Peoples R China.
C3 Hunan Agricultural University; Hunan Academy of Agricultural Sciences;
   Hunan Agricultural University
RP Qin, S (corresponding author), Hunan Agr Univ, Coll Food Sci & Technol, Changsha 410128, Peoples R China.; Zhou, XX; Qin, S (corresponding author), Hunan Agr Univ, Coll Biol Sci & Technol, Changsha 410128, Peoples R China.
EM zhouxixin@hunau.edu.cn; qinsiman@hunau.edu.cn
RI Li, Wenzhi/HNI-1471-2023; Lv, Chenghao/ABO-9390-2022
OI Lv, Chenghao/0000-0002-1165-2720
FU National Key Research and Development Program of China [2019YFC1604903];
   Hunan Natural Science Foundation [2023JJ30295]
FX Funding This work was supported by the grants from the National Key
   Research and Development Program of China (No. 2019YFC1604903) and the
   Hunan Natural Science Foundation (No. 2023JJ30295 to S.Q.) .
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NR 47
TC 0
Z9 0
U1 8
U2 8
PU SCIENCE PRESS
PI BEIJING
PA 16 DONGHUANGCHENGGEN NORTH ST, Building 5, Room 411, BEIJING, 100009,
   PEOPLES R CHINA
SN 1672-9145
EI 1745-7270
J9 ACTA BIOCH BIOPH SIN
JI Acta Biochim. Biophys. Sin.
PD SEP
PY 2024
VL 56
IS 9
BP 1300
EP 1310
DI 10.3724/abbs.2024042
PG 11
WC Biochemistry & Molecular Biology; Biophysics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics
GA M3Q5E
UT WOS:001356723600006
PM 38761010
OA gold
DA 2025-06-11
ER

PT J
AU Gao, LL
   Liu, XD
   Luo, XY
   Lou, XF
   Li, PS
   Li, X
   Liu, XM
AF Gao, Lulu
   Liu, Xudong
   Luo, Xiaoyan
   Lou, Xiaofan
   Li, Pusen
   Li, Xian
   Liu, Xiaomeng
TI Antiaging effects of dietary supplements and natural products
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Review
DE dietary supplements; natural products; aging; aging-realated disease;
   antiaging molecules
ID SCHISANDRA-CHINENSIS LIGNANS; OXIDATIVE STRESS; LIFE-SPAN;
   CARDIOVASCULAR-DISEASE; RESVERATROL DECREASES; CELLULAR SENESCENCE;
   INSULIN-RESISTANCE; NLRP3 INFLAMMASOME; METABOLIC SYNDROME;
   UP-REGULATION
AB Aging is an inevitable process influenced by genetics, lifestyles, and environments. With the rapid social and economic development in recent decades, the proportion of the elderly has increased rapidly worldwide, and many aging-related diseases have shown an upward trend, including nervous system diseases, cardiovascular diseases, metabolic diseases, and cancer. The rising burden of aging-related diseases has become an urgent global health challenge and requires immediate attention and solutions. Natural products have been used for a long time to treat various human diseases. The primary cellular pathways that mediate the longevity-extending effects of natural products involve nutrient-sensing pathways. Among them, the sirtuin, AMP-activated protein kinase, mammalian target of rapamycin, p53, and insulin/insulin-like growth factor-1 signaling pathways are most widely studied. Several studies have reviewed the effects of individual natural compounds on aging and aging-related diseases along with the underlying mechanisms. Natural products from food sources, such as polyphenols, saponins, alkaloids, and polysaccharides, are classified as antiaging compounds that promote health and prolong life via various mechanisms. In this article, we have reviewed several recently identified natural products with potential antiaging properties and have highlighted their cellular and molecular mechanisms. The discovery and use of dietary supplements and natural products that can prevent and treat multiple aging-related diseases in humans will be beneficial. Thus, this review provides theoretical background for existing dietary supplements and natural products as potential antiaging agents.
C1 [Gao, Lulu; Liu, Xudong; Luo, Xiaoyan; Lou, Xiaofan; Li, Pusen; Li, Xian; Liu, Xiaomeng] Xinxiang Med Univ, Sch Publ Hlth, Xinxiang, Henan, Peoples R China.
C3 Xinxiang Medical University
RP Liu, XM (corresponding author), Xinxiang Med Univ, Sch Publ Hlth, Xinxiang, Henan, Peoples R China.
EM lxmxm_99@126.com
RI Liu, Xudong/CAH-4068-2022; LUO, Xiaoyan/HIU-1105-2022
FU Henan Science and Technology Tackle Key Problems Program [232102310328];
   Innovation and Entrepreneurship Training Program for College Students of
   Henan Province [202310472021]; Xinxiang Medical University Talent
   (Doctor) Support Program [XYBSKYZZ202176]
FX This study supported by the Henan Science and Technology Tackle Key
   Problems Program (grant number 232102310328), the Innovation and
   Entrepreneurship Training Program for College Students of Henan Province
   (grant number 202310472021) and the Xinxiang Medical University Talent
   (Doctor) Support Program (grant number XYBSKYZZ202176).
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NR 213
TC 24
Z9 24
U1 2
U2 33
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD JUN 27
PY 2023
VL 14
AR 1192714
DI 10.3389/fphar.2023.1192714
PG 20
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA L9VP7
UT WOS:001026681000001
PM 37441528
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Sergi, D
   Sanz, JM
   Lazzer, S
   Brombo, G
   Zuliani, G
   Biolo, G
   Simunic, B
   Pisot, R
   Dalla Nora, E
   Passaro, A
AF Sergi, Domenico
   Sanz, Juana Maria
   Lazzer, Stefano
   Brombo, Gloria
   Zuliani, Giovanni
   Biolo, Gianni
   Simunic, Bostjan
   Pisot, Rado
   Dalla Nora, Edoardo
   Passaro, Angelina
TI Interleukin-18 Is a Potential Biomarker Linking Dietary Fatty Acid
   Quality and Insulin Resistance: Results from a Cross-Sectional Study in
   Northern Italy
SO NUTRIENTS
LA English
DT Article
DE IL-18; metabolic inflammation; insulin resistance; saturated fatty
   acids; monounsaturated fatty acids; omega-3 fatty acids; polyunsaturated
   fatty acids
ID METABOLIC SYNDROME; ADIPOSE-TISSUE; MEDITERRANEAN DIET; OLEIC-ACID;
   INFLAMMATION; OBESITY; EXPRESSION; STRESS; PLASMA; IL-18
AB Dietary lipids are pivotal in modulating metabolic inflammation. Among the inflammatory mediators characterizing metabolic inflammation, interleukin 18 (IL-18) has been consistently associated with obesity and insulin resistance. This study aims to evaluate whether the quality of lipid intake impacts upon IL-18 plasma levels and the implications on insulin resistance computed by the homeostatic model assessment for insulin resistance (HOMA-IR). Using a cross-sectional design, this study confirmed that IL-18 correlated positively with insulin resistance and individuals with a HOMA-IR = 2.5 displayed higher circulating IL-18 levels compared with their insulin-sensitive counterparts. In terms of the effect of the quality of dietary lipids on IL-18 circulating levels, the ratio between monounsaturated, omega-3, polyunsaturated and saturated fatty acids as well as the intake of eicosapentaenoic and docosahexaenoic acids correlated negatively with IL-18. Despite this, IL-18 circulating levels, but not dietary fatty acid quality, predicted insulin resistance. Nevertheless, the ratio between omega 3 and saturated fatty acids was a predictor of IL-18 plasma levels. Thus, the downregulation of IL-18 may underpin, at least partially, the beneficial metabolic effects of substituting omega 3 for saturated fatty acids with this cytokine potentially representing a biomarker linking dietary lipids and metabolic outcomes.
C1 [Sergi, Domenico; Zuliani, Giovanni; Passaro, Angelina] Univ Ferrara, Dept Translat Med, Via Luigi Borsari, 46, I-44121 Ferrara, Italy.
   [Sanz, Juana Maria] Univ Ferrara, Dept Chem & Pharmaceut Sci, Via Luigi Borsari, 46, I-44121 Ferrara, Italy.
   [Lazzer, Stefano] Univ Udine, Dept Med, Piazzale M Kolbe 4, I-33100 Udine, Italy.
   [Brombo, Gloria; Zuliani, Giovanni; Dalla Nora, Edoardo; Passaro, Angelina] Univ Hosp Ferrara Arcispedale Sant Anna, Med Dept, Via A Moro 8, I-44124 Ferrara, Italy.
   [Biolo, Gianni] Univ Trieste, Dept Med Surg & Hlth Sci, Str Fiume,447, I-34149 Trieste, Italy.
   [Simunic, Bostjan; Pisot, Rado] Sci & Res Ctr Koper, Inst Kinesiol Res, Garibaldijeva 1, Koper SI-6000, Slovenia.
C3 University of Ferrara; University of Ferrara; University of Udine;
   University of Trieste
RP Passaro, A (corresponding author), Univ Ferrara, Dept Translat Med, Via Luigi Borsari, 46, I-44121 Ferrara, Italy.; Passaro, A (corresponding author), Univ Hosp Ferrara Arcispedale Sant Anna, Med Dept, Via A Moro 8, I-44124 Ferrara, Italy.
EM angelina.passaro@unife.it
RI Simunic, Bostjan/MSX-2451-2025; Sanz, Juana/AAF-7941-2020; Biolo,
   Gianni/AAB-4983-2022; Brombo, Gloria/J-5215-2018; Sergi,
   Domenico/Q-5585-2017; Passaro, Angelina/P-3401-2015
OI Zuliani, Giovanni/0000-0003-0969-3184; BIOLO,
   GIANNI/0000-0002-6397-1598; Simunic, Bostjan/0000-0003-1565-7833; Sergi,
   Domenico/0000-0002-3001-410X; Passaro, Angelina/0000-0001-8462-7000;
   Sanz Molina, Juana Maria/0000-0003-3372-2758
FU Cross-border Cooperation Program Slovenia-Italy 2007-2013; European
   Regional Development Fund [042-2/2009-18/052012]
FX The study was conducted in the framework of the PANGeA project,
   CB147-Physical Activity and Nutrition for Quality Ageing, supported by
   the Cross-border Cooperation Program Slovenia-Italy 2007-2013 and
   co-financed by European Regional Development Fund Grant
   042-2/2009-18/052012.
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NR 58
TC 7
Z9 7
U1 0
U2 2
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD APR
PY 2023
VL 15
IS 7
AR 1782
DI 10.3390/nu15071782
PG 14
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA D6OT1
UT WOS:000969910600001
PM 37049621
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Mohammadifard, N
   Haghighatdoost, F
   Rahimlou, M
   Rodrigues, APS
   Gaskarei, MK
   Okhovat, P
   de Oliveira, C
   Silveira, EA
   Sarrafzadegan, N
AF Mohammadifard, Noushin
   Haghighatdoost, Fahimeh
   Rahimlou, Mehran
   Santos Rodrigues, Ana Paula
   Gaskarei, Mohammadamin Khajavi
   Okhovat, Paria
   de Oliveira, Cesar
   Silveira, Erika Aparecida
   Sarrafzadegan, Nizal
TI The Effect of Ketogenic Diet on Shared Risk Factors of Cardiovascular
   Disease and Cancer
SO NUTRIENTS
LA English
DT Review
DE ketogenic diet; cardiovascular disease; cancer; hypertension; oxidation;
   inflammation; diabetes; obesity
ID MITOCHONDRIAL-DNA MUTATIONS; LOW-CARBOHYDRATE DIET; KETONE-BODIES;
   OXIDATIVE STRESS; INSULIN-RESISTANCE; METABOLIC SYNDROME; FAVORABLE
   IMPACT; FATTY-ACIDS; WEIGHT-LOSS; OBESITY
AB Cardiovascular disease (CVD) and cancer are the first and second leading causes of death worldwide, respectively. Epidemiological evidence has demonstrated that the incidence of cancer is elevated in patients with CVD and vice versa. However, these conditions are usually regarded as separate events despite the presence of shared risk factors between both conditions, such as metabolic abnormalities and lifestyle. Cohort studies suggested that controlling for CVD risk factors may have an impact on cancer incidence. Therefore, it could be concluded that interventions that improve CVD and cancer shared risk factors may potentially be effective in preventing and treating both diseases. The ketogenic diet (KD), a low-carbohydrate and high-fat diet, has been widely prescribed in weight loss programs for metabolic abnormalities. Furthermore, recent research has investigated the effects of KD on the treatment of numerous diseases, including CVD and cancer, due to its role in promoting ketolysis, ketogenesis, and modifying many other metabolic pathways with potential favorable health effects. However, there is still great debate regarding prescribing KD in patients either with CVD or cancer. Considering the number of studies on this topic, there is a clear need to summarize potential mechanisms through which KD can improve cardiovascular health and control cell proliferation. In this review, we explained the history of KD, its types, and physiological effects and discussed how it could play a role in CVD and cancer treatment and prevention.
C1 [Mohammadifard, Noushin; Sarrafzadegan, Nizal] Isfahan Univ Med Sci, Isfahan Cardiovasc Res Ctr, Cardiovasc Res Inst, Esfahan 8158388994, Iran.
   [Haghighatdoost, Fahimeh] Isfahan Univ Med Sci, Intervent Cardiol Res Ctr, Cardiovasc Res Inst, Esfahan 8158388994, Iran.
   [Rahimlou, Mehran] Zanjan Univ Med Sci, Fac Med, Dept Nutr, Zanjan 4515863994, Iran.
   [Santos Rodrigues, Ana Paula] Goias State Hlth Dept, Hlth Care Superintendence, BR-74093250 Goiania, Go, Brazil.
   [Gaskarei, Mohammadamin Khajavi] Isfahan Univ Med Sci, Heart Failure Res Ctr, Cardiovasc Res Inst, Esfahan 8158388994, Iran.
   [Okhovat, Paria] Isfahan Univ Med Sci, Pediat Cardiovasc Res Ctr, Cardiovasc Res Inst, Esfahan 8158388994, Iran.
   [de Oliveira, Cesar; Silveira, Erika Aparecida] UCL, Inst Epidemiol & Hlth Care, Dept Epidemiol & Publ Hlth, London WC1E 6BT, England.
   [Silveira, Erika Aparecida] Univ Fed Goias, Fac Med, Postgrad Program Hlth Sci, BR-74690900 Goiania, Go, Brazil.
   [Sarrafzadegan, Nizal] Univ British Columbia, Fac Med, Sch Populat & Publ Hlth, Vancouver, BC V6T 1Z3, Canada.
C3 Isfahan University of Medical Sciences; Isfahan University of Medical
   Sciences; Isfahan University of Medical Sciences; Isfahan University of
   Medical Sciences; University of London; University College London;
   Universidade Federal de Goias; University of British Columbia
RP Haghighatdoost, F (corresponding author), Isfahan Univ Med Sci, Intervent Cardiol Res Ctr, Cardiovasc Res Inst, Esfahan 8158388994, Iran.
EM f_haghighatdoost@yahoo.com
RI Rodrigues, Ana Paula/AHI-7561-2022; Rahimlou, Mehran/AAL-4902-2021;
   Mohammadifard, Noushin/M-2244-2018; Silveira, Erika
   Aparecida/O-7585-2018
OI De Oliveira, Cesar/0000-0002-4099-4762; Haghighatdoost,
   Fahimeh/0000-0003-4766-6267; Mohammadifard, Noushin/0000-0003-1776-1060;
   Sarrafzadegan, Nizal/0000-0002-6828-2169; Silveira, Erika
   Aparecida/0000-0002-8839-4520; Rodrigues, Ana Paula/0000-0002-0447-898X
FU Economic and Social Research Council [ES/T008822/1]; ESRC [ES/T008822/1]
   Funding Source: UKRI
FX The Economic and Social Research Council supported this work (grant
   number ES/T008822/1).
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TC 45
Z9 46
U1 1
U2 20
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD SEP
PY 2022
VL 14
IS 17
AR 3499
DI 10.3390/nu14173499
PG 22
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 4K5LP
UT WOS:000851991300001
PM 36079756
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Sánchez, DCV
   Castellanos, SG
   Sandoval, MEV
   García, AG
AF Villalpando Sanchez, Diana Carolina
   Gutierrez Castellanos, Sergio
   Viveros Sandoval, Martha Eva
   Gomez Garcia, Anel
TI B-Cell Activating Factor Increases Related to Adiposity, Insulin
   Resistance, and Endothelial Dysfunction in Overweight and Obese Subjects
SO LIFE-BASEL
LA English
DT Article
DE B-cell activating factor; obesity; insulin resistance; inflammation;
   endothelial dysfunction; von Willebrand factor
ID METABOLIC SYNDROME; OXIDATIVE STRESS; WEIGHT-LOSS; FACTOR BAFF;
   TNF-ALPHA; INFLAMMATION; PREVALENCE; CYTOKINES; MARKERS; ADIPOKINE
AB Obesity (OB) is a major healthcare problem that results from long-term energy imbalance. Adipokines and pro-inflammatory cytokines facilitate adipose tissue (AT) remodeling to safely store excess nutrients. B-cell activating factor (BAFF) is a newly described adipokine whose role in enhancing adipogenesis has been reported. The present study aimed to evaluate serum BAFF association with adiposity distribution, serum adipokines, pro-inflammatory cytokines, and metabolic and endothelial dysfunction markers. The study included 124 young Mexican adults with no diagnosed comorbidities, divided according to their BMI. Anthropometric measurements, blood counts, and serum molecules (i.e., glucose, lipid profile, insulin, leptin, pro- and anti-inflammatory cytokines, von Willebrand factor (vWF), and BAFF) were assessed. The analysis showed positive correlation between BAFF and increased fat mass in all anthropometric measurements (p < 0.0001). BAFF augmentation was related to systemic inflammatory environment (p < 0.05), and linked with insulin resistance status (p < 0.05). BAFF increment was also correlated with early endothelial damage markers such as vWF (p < 0.0001). Linear regression analysis showed a role for BAFF in predicting serum vWF concentrations (p < 0.01). In conclusion, our data show that BAFF is an adipokine dynamically related to OB progression, insulin resistance status, and systemic inflammatory environment, and is a predictor of soluble vWF augmentation, in young overweight and obese Mexican subjects.
C1 [Villalpando Sanchez, Diana Carolina] Inst Politecn Nacl, Dept Inmunol, Escuela Nacl Ciencias Biol, Mexico City 11340, DF, Mexico.
   [Villalpando Sanchez, Diana Carolina] Inst Politecn Nacl, Escuela Nacl Ciencias Biol, Posgrad Inmunol, Mexico City 11340, DF, Mexico.
   [Villalpando Sanchez, Diana Carolina; Gutierrez Castellanos, Sergio; Gomez Garcia, Anel] Inst Mexicano Seguro Social, Div Invest Clin, Ctr Invest Biomed Michoacan, Morelia 58341, Michoacan, Mexico.
   [Gutierrez Castellanos, Sergio] Univ Michoacana, Lab Citopatol Mol, Div Estudios Posgrad, Fac Ciencias Med & Biol Dr Ignacio Chavez, Morelia 58020, Michoacan, Mexico.
   [Viveros Sandoval, Martha Eva] Univ Michoacana, Fac Ciencias Med & Biol Dr Ignacio Chavez, Div Estudios Posgrad, Lab Hemostasia & Biol Vasc, Morelia 58020, Michoacan, Mexico.
C3 Instituto Politecnico Nacional - Mexico; Instituto Politecnico Nacional
   - Mexico; Instituto Mexicano del Seguro Social; Universidad Michoacana
   de San Nicolas de Hidalgo; Universidad Michoacana de San Nicolas de
   Hidalgo
RP García, AG (corresponding author), Inst Mexicano Seguro Social, Div Invest Clin, Ctr Invest Biomed Michoacan, Morelia 58341, Michoacan, Mexico.
EM dvillalpandos1901@alumno.ipn.mx; sergio.gutierrez@umich.mx;
   martha.viveros@umich.mx; anel.gomez@imss.gob.mx
RI GOMEZ GARCIA, ANEL/W-6882-2019
OI VILLALPANDO-SANCHEZ, DIANA/0000-0003-1121-6168; GOMEZ GARCIA,
   ANEL/0000-0002-9158-1095
FU Fondo de Investigacion en Salud-IMSS [FIS/IMSS/PROT/MD17/1687]
FX This research was financed by the Fondo de Investigacion en Salud-IMSS:
   FIS/IMSS/PROT/MD17/1687.
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NR 63
TC 8
Z9 8
U1 0
U2 0
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2075-1729
J9 LIFE-BASEL
JI Life-Basel
PD MAY
PY 2022
VL 12
IS 5
AR 634
DI 10.3390/life12050634
PG 14
WC Biology; Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics; Microbiology
GA 1Q5PA
UT WOS:000802737800001
PM 35629302
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Jiang, Y
   Rodgers, B
   Damiris, K
   Choi, C
   Ahlawat, S
AF Jiang, Yi
   Rodgers, Brandon
   Damiris, Konstantinos
   Choi, Catherine
   Ahlawat, Sushil
TI The effects of diabetes mellitus on clinical outcomes of hospitalized
   patients with acute diverticulitis
SO EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
LA English
DT Article
DE acute diverticulitis; complicated diabetes; diabetes mellitus;
   diverticulitis complications
ID RISK-FACTORS; GUT MICROBIOTA; UNITED-STATES; METABOLIC SYNDROME;
   OXIDATIVE STRESS; DISEASE; METFORMIN; INFLAMMATION; OBESITY;
   ATHEROSCLEROSIS
AB Objectives Acute diverticulitis is a common gastrointestinal illness due to diverticular inflammation and focal necrosis. Diabetes mellitus has been reported to influence the outcomes of patients with diverticular disease. Our study aimed to examine the inpatient outcomes and complications of patients with acute diverticulitis and coexisting diabetes mellitus. Methods The Nationwide Inpatient Sample was used to identify adult patients in 2014 admitted for acute diverticulitis. Primary outcomes were mortality, length of stay (LOS), and total hospitalization charges. Secondary outcomes were complications of acute diverticulitis and interventions. Results In total, 44 330 of patients with acute diverticulitis and diabetes mellitus were included in the analysis. Acute diverticulitis patients with diabetes mellitus had a higher rate of diverticular bleeding (P < 0.0001), but lower rates of abscess (P < 0.0001), obstruction (P < 0.0001) and colectomy (P < 0.0001) when compared to acute diverticulitis patients without diabetes mellitus. Complicated diabetes mellitus was associated with a longer LOS (P = 0.00003) and greater total hospitalization charges (P = 0.0021) compared to uncomplicated diabetes mellitus when coexisting with acute diverticulitis. Conclusions Acute diverticulitis with diabetes mellitus is associated with a higher rate of diverticular bleeding, lower rates of abscess, obstruction, and colectomy compared to acute diverticulitis without diabetes mellitus. When coexisting with acute diverticulitis, complicated diabetes mellitus is not associated with higher rates of mortality or diverticulitis-related complications compared to uncomplicated diabetes mellitus.
C1 [Jiang, Yi; Rodgers, Brandon; Damiris, Konstantinos; Choi, Catherine] Rutgers New Jersey Med Sch, Dept Med, 150 Bergen St,UH I-248, Newark, NJ 07101 USA.
   [Ahlawat, Sushil] Rutgers New Jersey Med Sch, Div Gastroenterol & Hepatol, Newark, NJ USA.
C3 Rutgers University System; Rutgers University New Brunswick; Rutgers
   University Biomedical & Health Sciences; Rutgers University System;
   Rutgers University New Brunswick; Rutgers University Biomedical & Health
   Sciences
RP Jiang, Y (corresponding author), Rutgers New Jersey Med Sch, Dept Med, 150 Bergen St,UH I-248, Newark, NJ 07101 USA.
EM yi.jiang@rutgers.edu
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NR 64
TC 1
Z9 1
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0954-691X
EI 1473-5687
J9 EUR J GASTROEN HEPAT
JI Eur. J. Gastroenterol. Hepatol.
PD NOV
PY 2021
VL 33
IS 11
BP 1354
EP 1360
DI 10.1097/MEG.0000000000001895
PG 7
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA WB7IM
UT WOS:000703742800004
PM 32796358
DA 2025-06-11
ER

PT J
AU Rodriguez-Rodriguez, AE
   Porrini, E
   Torres, A
AF Elena Rodriguez-Rodriguez, Ana
   Porrini, Esteban
   Torres, Armando
TI Beta-Cell Dysfunction Induced by Tacrolimus: A Way to Explain Type 2
   Diabetes?
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE pancreatic beta-cells; diabetes mellitus type 2; post-transplant
   diabetes mellitus; tacrolimus; pathways
ID INSULIN GENE-TRANSCRIPTION; ACTIVATED PROTEIN-KINASE; PANCREATIC-ISLETS;
   MAMMALIAN TARGET; OXIDATIVE STRESS; MAFA EXPRESSION; CYCLOSPORINE-A;
   FACTOR PDX-1; JNK PATHWAY; GLUCOSE
AB The combination of insulin resistance and beta-cells dysfunction leads to the onset of type-2 diabetes mellitus (T2DM). This process can last for decades, as beta-cells are able to compensate the demand for insulin and maintain normoglycemia. Understanding the adaptive capacity of beta-cells during this process and the causes of its failure is essential to the limit onset of diabetes. Post-transplant diabetes mellitus (PTDM) is a common and serious disease that affects 30% of renal transplant recipients. With the exception of immunosuppressive therapy, the risk factors for T2D are the same as for PTDM: obesity, dyslipidaemia, insulin resistance and metabolic syndrome. Tacrolimus (TAC) is the immunosuppressant of choice after renal transplantation but it has the highest rates of PTDM. Our group has shown that insulin resistance and glucolipotoxicity, without favouring the appearance of apoptosis, modify key nuclear factors for the maintenance of identity and functionality of beta-cells. In this context, TAC accelerates or enhances these changes. Our hypothesis is that the pathways that are affected in the progression from pre-diabetes to diabetes in the general population are the same pathways that are affected by TAC. So, TAC can be considered a tool to study the pathogenesis of T2DM. Here, we review the common pathways of beta-cells dysfunction on T2DM and TAC-induced diabetes.
C1 [Elena Rodriguez-Rodriguez, Ana] Hosp Univ Canarias, Res Unit, San Cristobal la Laguna 38320, Santa Cruz De T, Spain.
   [Elena Rodriguez-Rodriguez, Ana] Univ La Laguna, Fdn Gen Univ, San Cristobal la Laguna 38204, Santa Cruz De T, Spain.
   [Porrini, Esteban; Torres, Armando] Hosp Univ Canarias, Unidad Ensayos Clin UCICEC, San Cristobal la Laguna 38320, Santa Cruz De T, Spain.
   [Porrini, Esteban] Univ La Laguna, Inst Tecnol Biomed ITB, San Cristobal la Laguna 38200, Santa Cruz De T, Spain.
   [Torres, Armando] Hosp Univ Canarias, Nephrol Dept, San Cristobal la Laguna 38320, Santa Cruz De T, Spain.
C3 Universidad de la Laguna; University Hospital of the Canary Islands;
   Universidad de la Laguna; Universidad de la Laguna; University Hospital
   of the Canary Islands; Universidad de la Laguna; Universidad de la
   Laguna; University Hospital of the Canary Islands
RP Porrini, E (corresponding author), Hosp Univ Canarias, Unidad Ensayos Clin UCICEC, San Cristobal la Laguna 38320, Santa Cruz De T, Spain.; Porrini, E (corresponding author), Univ La Laguna, Inst Tecnol Biomed ITB, San Cristobal la Laguna 38200, Santa Cruz De T, Spain.
EM anarrguez@gmail.com; esteban.l.porrini@gmail.com; atorres@ull.es4
OI Rodriguez-Rodriguez, Ana Elena/0000-0002-0803-864X; Torres,
   Armando/0000-0003-1121-5173
FU ERA-EDTA long-term fellowships programme; Program Ramon y Cajal
   [RYC-2014-16573]; IMBRAIN project
   [FP7-RE6-POT-2012-CT2012-31637-IMBRAIN]; Institute Carlos III
   [PI16/01814, PI19/01187]; SENEFRO foundation; Sociedad Espanola de
   Nefrologia (S.E.N.)
FX AERR is a researcher of the ERA-EDTA long-term fellowships programme; EP
   is a researcher of the Program Ramon y Cajal (RYC-2014-16573). We thank
   the IMBRAIN project for support (FP7-RE6-POT-2012-CT2012-31637-IMBRAIN)
   funded under the 7th Frameworks Programme capacities, the Institute
   Carlos III for the grants: PI16/01814 (EP) and PI19/01187 (AT), and the
   SENEFRO foundation and Sociedad Espanola de Nefrologia (S.E.N.) for the
   research grant (AERR).
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NR 106
TC 26
Z9 28
U1 0
U2 14
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD OCT
PY 2021
VL 22
IS 19
AR 10311
DI 10.3390/ijms221910311
PG 14
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA WH3FX
UT WOS:000707569300001
PM 34638652
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Hara, F
   Tatebe, J
   Watanabe, I
   Yamazaki, J
   Ikeda, T
   Morita, T
AF Hara, Fumihiko
   Tatebe, Junko
   Watanabe, Ippei
   Yamazaki, Junichi
   Ikeda, Takanori
   Morita, Toshisuke
TI Molecular Hydrogen Alleviates Cellular Senescence in Endothelial Cells
SO CIRCULATION JOURNAL
LA English
DT Article
DE Antioxidant; Endothelial senescence; Molecular hydrogen; Nrf2
ID ARYL-HYDROCARBON RECEPTOR; POTENTIAL METABOLIC SYNDROME; E KNOCKOUT
   MICE; RICH WATER; PREMATURE SENESCENCE; OXIDATIVE STRESS;
   ATHEROSCLEROSIS; CONSUMPTION; ANTIOXIDANT; ACTIVATION
AB Background: Substantial evidence indicates that molecular hydrogen (H-2) has beneficial vascular effects because of its antioxidant and/or anti-inflammatory effects. Thus, hydrogen-rich water may prove to be an effective anti-aging drink. This study examined the effects of H-2 on endothelial senescence and clarified the mechanisms involved.
   Methods and Results: Hydrogen-rich medium was produced by a high-purity hydrogen gas generator. Human umbilical vein endothelial cells (HUVECs) were incubated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) for various time periods in normal or hydrogen-rich medium. The baseline H-2 concentration in hydrogen-rich medium was 0.55 +/- 0.07 mmol/L. This concentration gradually decreased, and H-2 was almost undetectable in medium after 12 h. At 24 h after TCDD exposure, HUVECs treated with TCDD exhibited increased 8OHdG and acetyl-p53 expression, decreased nicotinamide adenine dinucleotide (NAD+)/NADH ratio, impaired Sirt1 activity, and enhanced senescence-associated beta-galactosidase. However, HUVECs incubated in hydrogen-rich medium did not exhibit these TCDD-induced changes accompanying Nrf2 activation, which was observed even after H-2 was undetectable in the medium. Chrysin, an inhibitor of Nrf2, abolished the protective effects of H-2 on HUVECs.
   Conclusions: H-2 has long-lasting antioxidant and anti-aging effects on vascular endothelial cells through the Nrf2 pathway, even after transient exposure to H-2. Hydrogen-rich water may thus be a functional drink that increases longevity.
C1 [Hara, Fumihiko; Watanabe, Ippei; Yamazaki, Junichi; Ikeda, Takanori] Toho Univ, Sch Med, Dept Cardiovasc Med, Tokyo, Japan.
   [Tatebe, Junko; Morita, Toshisuke] Toho Univ, Sch Med, Dept Lab Med, Tokyo, Japan.
C3 Toho University; Toho University
RP Morita, T (corresponding author), Toho Univ, Ota Ku, 6-11-1 Omori Nishi, Tokyo 1438541, Japan.
EM toshimrt@med.toho-u.ac.jp
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NR 35
TC 26
Z9 28
U1 0
U2 21
PU JAPANESE CIRCULATION SOC
PI TOYKO
PA 18TH FLOOR IMPERIAL HOTEL TOWER, 1-1-1 UCHISAIWAI-CHO CHIYODA-KU, TOYKO,
   100-0011, JAPAN
SN 1346-9843
EI 1347-4820
J9 CIRC J
JI Circ. J.
PD SEP
PY 2016
VL 80
IS 9
BP 2037
EP 2046
DI 10.1253/circj.CJ-16-0227
PG 10
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA DW7AZ
UT WOS:000383804700028
PM 27477846
OA gold
DA 2025-06-11
ER

PT J
AU Zheng, Z
   Zhang, XB
   Wang, JM
   Dandekar, A
   Kim, H
   Qiu, YN
   Xu, XH
   Cui, YQ
   Wang, AX
   Chen, LC
   Rajagopalan, S
   Sun, QH
   Zhang, KZ
AF Zheng, Ze
   Zhang, Xuebao
   Wang, Jiemei
   Dandekar, Aditya
   Kim, Hyunbae
   Qiu, Yining
   Xu, Xiaohua
   Cui, Yuqi
   Wang, Aixia
   Chen, Lung Chi
   Rajagopalan, Sanjay
   Sun, Qinghua
   Zhang, Kezhong
TI Exposure to fine airborne particulate matters induces hepatic fibrosis
   in murine models
SO JOURNAL OF HEPATOLOGY
LA English
DT Article
DE Air pollution; Hepatic fibrosis; PM2.5
ID PROLIFERATOR-ACTIVATED RECEPTORS; AMBIENT PARTICLES CAPS; AIR-POLLUTION;
   SUBCHRONIC EXPOSURES; STRESS-RESPONSE; TGF-BETA; CELL; INFLAMMATION;
   MICE; POPULATION
AB Background & Aims: Hepatic fibrosis, featured by the accumulation of excessive extracellular matrix in liver tissue, is associated with metabolic disease and cancer. Inhalation exposure to airborne particulate matter in fine ranges (PM2.5) correlates with pulmonary dysfunction, cardiovascular disease, and metabolic syndrome. In this study, we investigated the effect and mechanism of PM2.5 exposure on hepatic fibrogenesis.
   Methods: Both inhalation exposure of mice and in vitro exposure of specialized cells to PM2.5 were performed to elucidate the effect of PM2.5 exposure on hepatic fibrosis. Histological examinations, gene expression analyses, and genetic animal models were utilized to determine the effect and mechanism by which PM2.5 exposure promotes hepatic fibrosis.
   Results: Inhalation exposure to concentrated ambient PM2.5 induces hepatic fibrosis in mice under the normal chow or high-fat diet. Mice after PM2.5 exposure displayed increased expression of collagens in liver tissues. Exposure to PM2.5 led to activation of the transforming growth factor beta-SMAD3 signaling, suppression of peroxisome proliferator-activated receptor 7, and expression of collagens in hepatic stellate cells. NADPH oxidase plays a critical role in PM2.5-induced liver fibrogenesis.
   Conclusions: Exposure to PM2.5 exerts discernible effects on promoting hepatic fibrogenesis. NADPH oxidase mediates the effects of PM2.5 exposure on promoting hepatic fibrosis. (C) 2015 Published by Elsevier B.V. on behalf of the European Association for the Study of the Liver.
C1 [Zheng, Ze; Zhang, Xuebao; Wang, Jiemei; Kim, Hyunbae; Qiu, Yining; Zhang, Kezhong] Wayne State Univ, Sch Med, Ctr Mol Med & Genet, Detroit, MI 48201 USA.
   [Dandekar, Aditya; Zhang, Kezhong] Wayne State Univ, Sch Med, Dept Immunol & Microbiol, Detroit, MI 48201 USA.
   [Cui, Yuqi; Wang, Aixia; Rajagopalan, Sanjay; Sun, Qinghua] Ohio State Univ, Coll Med, Davis Heart & Lung Res Inst, Div Cardiovasc Med, Columbus, OH 43210 USA.
   [Xu, Xiaohua; Wang, Aixia; Sun, Qinghua] Ohio State Univ, Coll Publ Hlth, Div Environm Hlth Sci, Columbus, OH 43210 USA.
   [Chen, Lung Chi] New York Univ, Dept Environm Med, Tuxedo Pk, NY 10987 USA.
C3 Wayne State University; Wayne State University; University System of
   Ohio; Ohio State University; University System of Ohio; Ohio State
   University; New York University
RP Zhang, KZ (corresponding author), 540 E Canfield Ave, Detroit, MI 48201 USA.
EM kzhang@med.wayne.edu
RI Cui, Yuqi/U-5914-2017; Sun, Qinghua/E-4167-2011; Zhang,
   Zhiwu/P-6156-2016; Dandekar, Aditya/L-9510-2019; Wang,
   Jiemei/N-9528-2019; WANG, JIEMEI/D-6317-2012
OI WANG, JIEMEI/0000-0002-8723-4410; Zhang, Kezhong/0000-0002-6062-235X;
   Zheng, Ze/0000-0002-4453-224X
FU National Institutes of Health (NIH) [DK090313, ES017829]; American Heart
   Association [0635423Z, 09GRNT2280479]; NIH [ES018900, R01ES019616,
   R01ES017290, R01ES015146]; American Heart Association (AHA) [0635423Z]
   Funding Source: American Heart Association (AHA); National Institute of
   Diabetes and Digestive and Kidney Diseases [P30DK020572] Funding Source:
   NIH RePORTER
FX Portions of this work were supported by National Institutes of Health
   (NIH) grants DK090313 and ES017829 to KZ, American Heart Association
   Grants 0635423Z and 09GRNT2280479 to KZ, NIH grant ES018900 to QS, and
   NIH grants R01ES019616, R01ES017290, and R01ES015146 to SR. We thank Dr.
   Scott Friedman for kindly providing LX-2 cells and Dr. Todd Leff for
   providing pioglitazone.
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NR 39
TC 157
Z9 167
U1 2
U2 90
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0168-8278
EI 1600-0641
J9 J HEPATOL
JI J. Hepatol.
PD DEC
PY 2015
VL 63
IS 6
BP 1397
EP 1404
DI 10.1016/j.jhep.2015.07.020
PG 8
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA CX0DE
UT WOS:000365366300015
PM 26220751
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Lane, M
   McPherson, NO
   Fullston, T
   Spillane, M
   Sandeman, L
   Kang, WX
   Zander-Fox, DL
AF Lane, Michelle
   McPherson, Nicole O.
   Fullston, Tod
   Spillane, Marni
   Sandeman, Lauren
   Kang, Wan Xian
   Zander-Fox, Deirdre L.
TI Oxidative Stress in Mouse Sperm Impairs Embryo Development, Fetal Growth
   and Alters Adiposity and Glucose Regulation in Female Offspring
SO PLOS ONE
LA English
DT Article
ID OXYGEN SPECIES GENERATION; DIET-INDUCED OBESITY; BODY-MASS INDEX;
   TRANSCRIPTIONAL PROFILE; BLASTOCYST DEVELOPMENT; PHYSIOLOGICAL CONTROL;
   HUMAN SPERMATOZOA; PATERNAL OBESITY; FERTILIZATION; RESTRICTION
AB Paternal health cues are able to program the health of the next generation however the mechanism for this transmission is unknown. Reactive oxygen species (ROS) are increased in many paternal pathologies, some of which program offspring health, and are known to induce DNA damage and alter the methylation pattern of chromatin. We therefore investigated whether a chemically induced increase of ROS in sperm impairs embryo, pregnancy and offspring health. Mouse sperm was exposed to 1500 mu M of hydrogen peroxide (H2O2), which induced oxidative damage, however did not affect sperm motility or the ability to bind and fertilize an oocyte. Sperm treated with H2O2 delayed on-time development of subsequent embryos, decreased the ratio of inner cell mass cells (ICM) in the resulting blastocyst and reduced implantation rates. Crown-rump length at day 18 of gestation was also reduced in offspring produced by H2O2 treated sperm. Female offspring from H2O2 treated sperm were smaller, became glucose intolerant and accumulated increased levels of adipose tissue compared to control female offspring. Interestingly male offspring phenotype was less severe with increases in fat depots only seen at 4 weeks of age, which was restored to that of control offspring later in life, demonstrating sex-specific impacts on offspring. This study implicates elevated sperm ROS concentrations, which are common to many paternal health pathologies, as a mediator of programming offspring for metabolic syndrome and obesity.
C1 [Lane, Michelle; McPherson, Nicole O.; Fullston, Tod; Spillane, Marni; Sandeman, Lauren; Kang, Wan Xian; Zander-Fox, Deirdre L.] Univ Adelaide, Sch Paediat & Reprod Hlth, Discipline Obstet & Gynaecol, Adelaide, SA 5005, Australia.
   [Lane, Michelle; McPherson, Nicole O.; Fullston, Tod; Spillane, Marni; Sandeman, Lauren; Kang, Wan Xian; Zander-Fox, Deirdre L.] Univ Adelaide, Robinson Inst, Adelaide, SA 5005, Australia.
   [Lane, Michelle; Zander-Fox, Deirdre L.] Repromed, Dulwich, SA, Australia.
C3 University of Adelaide; University of Adelaide; Robinson Research
   Institute
RP Lane, M (corresponding author), Univ Adelaide, Sch Paediat & Reprod Hlth, Discipline Obstet & Gynaecol, Adelaide, SA 5005, Australia.
EM michelle.lane@adelaide.edu.au
OI McPherson, Nicole/0000-0002-3492-9403
FU NHMRC; Australian Post Graduate Award; Prospective Lodge Freemasons
   Scholarship; Freemasons Lodge St Albans Research Scholarship
FX This research was funded by NHMRC project grant awarded to ML. ML was
   supported by NHMRC Senior Research Fellowship, NOM by an Australian Post
   Graduate Award and a Prospective Lodge Freemasons Scholarship, TF by
   NHMRC Peter Doherty Fellowship, and MS by 2012 Freemasons Lodge St
   Albans Research Scholarship. The funders had no role in study design,
   data collection and analysis, decision to publish, or preparation of the
   manuscript.
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NR 64
TC 106
Z9 114
U1 1
U2 22
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JUL 9
PY 2014
VL 9
IS 7
AR e100832
DI 10.1371/journal.pone.0100832
PG 9
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA AL3PK
UT WOS:000339040600020
PM 25006800
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Triolo, M
   de Boer, JF
   Annema, W
   Kwakernaak, AJ
   Tietge, UJF
   Dullaart, RPF
AF Triolo, Michela
   de Boer, Jan Freark
   Annema, Wijtske
   Kwakernaak, Arjan J.
   Tietge, Uwe J. F.
   Dullaart, Robin P. F.
TI Low normal free T4 confers decreased high-density lipoprotein
   antioxidative functionality in the context of hyperglycaemia
SO CLINICAL ENDOCRINOLOGY
LA English
DT Article
ID CORONARY-HEART-DISEASE; ELEVATED OXIDATIVE STRESS; SUBCLINICAL
   HYPOTHYROIDISM; METABOLIC SYNDROME; CARDIOVASCULAR RISK;
   THYROID-FUNCTION; FREE-THYROXINE; HDL; CHOLESTEROL; PARTICLES
AB Objectives Low normal thyroid function may promote the development of atherosclerotic cardiovascular disease by thus far poorly defined mechanisms. We tested the impact of thyroid function on HDL antioxidative capacity, a metric of its anti-atherogenic functionality, in euthyroid subjects with varying degrees of glucose tolerance.
   Design and Subjects Seventy subjects with Type 2 diabetes mellitus (T2DM), 37 subjects with impaired fasting glucose (IFG) and 31 subjects with normal fasting glucose (NFG) (revised NCEP-ATPIII criteria) participated in a cross-sectional study.
   Measurements HDL antioxidative capacity (standardized for HDL cholesterol) was measured as the percentage inhibition of low-density lipoprotein oxidation in vitro.
   Results TSH, free T4 and HDL antioxidative capacity were not different among NFG, IFG and T2DM subjects (P > 0.25 for each). HDL antioxidative capacity was correlated positively with free T4 (r = 0.320, P = 0.007), and negatively with plasma glucose (r = -0.394, P < 0.001) in T2DM only. Taking account of age and sex, the relationship of HDL antioxidative functionality with free T4 was modified by glucose tolerance status (P = 0.040 and P = 0.008 for interactions of IFG and T2DM with free T4 respectively). Prevailing plasma glucose also interacted positively with free T4 on HDL antioxidative capacity (P = 0.054).
   Conclusions In the context of chronic hyperglycaemia, low free T4 within the euthyroid range confers diminished HDL antioxidative capacity, a pathophysiologically relevant metric of HDL functionality.
C1 [Triolo, Michela; Dullaart, Robin P. F.] Univ Groningen, Univ Med Ctr Groningen, Dept Endocrinol, NL-9700 RB Groningen, Netherlands.
   [de Boer, Jan Freark; Annema, Wijtske; Tietge, Uwe J. F.] Univ Med Ctr Groningen, Ctr Liver Digest & Metab Dis, Dept Pediat, NL-9700 RB Groningen, Netherlands.
   [de Boer, Jan Freark; Annema, Wijtske; Kwakernaak, Arjan J.; Tietge, Uwe J. F.] Univ Groningen, Groningen, Netherlands.
   [Annema, Wijtske; Tietge, Uwe J. F.] Top Insititute Food & Nutr, Wageningen, Netherlands.
   [Kwakernaak, Arjan J.] Univ Groningen, Univ Med Ctr Groningen, Dept Nephrol, NL-9700 RB Groningen, Netherlands.
C3 University of Groningen; University of Groningen; University of
   Groningen; Top Institute Food & Nutrition; University of Groningen
RP Dullaart, RPF (corresponding author), Univ Groningen, Univ Med Ctr Groningen, Dept Endocrinol, POB 30001, NL-9700 RB Groningen, Netherlands.
EM r.p.f.dullaart@int.umcg.nl
OI Triolo, Michela/0000-0001-6603-3102
FU Dutch Diabetes Research Foundation; Top Institute (TI) Food and
   Nutrition; Groningen Expert Center for Kids with Obesity
FX This study was supported in part by a grant from the Dutch Diabetes
   Research Foundation to R. P. F. Dullaart. U.J.F. Tietge is supported by
   grants from the Top Institute (TI) Food and Nutrition and the Groningen
   Expert Center for Kids with Obesity.
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NR 37
TC 15
Z9 16
U1 0
U2 10
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0300-0664
EI 1365-2265
J9 CLIN ENDOCRINOL
JI Clin. Endocrinol.
PD SEP
PY 2013
VL 79
IS 3
BP 416
EP 423
DI 10.1111/cen.12138
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 188IO
UT WOS:000322186700019
PM 23278171
DA 2025-06-11
ER

PT J
AU Volat, FE
   Pointud, JC
   Pastel, E
   Morio, B
   Sion, B
   Hamard, G
   Guichardant, M
   Colas, R
   Lefrançois-Martinez, AM
   Martinez, A
AF Volat, Fanny E.
   Pointud, Jean-Christophe
   Pastel, Emilie
   Morio, Beatrice
   Sion, Benoit
   Hamard, Ghislaine
   Guichardant, Michel
   Colas, Romain
   Lefrancois-Martinez, Anne-Marie
   Martinez, Antoine
TI Depressed Levels of Prostaglandin F2α in Mice Lacking Akr1b7
   Increase Basal Adiposity and Predispose to Diet-Induced Obesity
SO DIABETES
LA English
DT Article
ID VAS-DEFERENS PROTEIN; ALDOSE REDUCTASE AKR1B1; ADIPOCYTE
   DIFFERENTIATION; OXIDATIVE STRESS; GLUCOSE-HOMEOSTASIS;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; GENE-EXPRESSION; F SYNTHASE; X
   RECEPTOR
AB Negative regulators of white adipose tissue (WAT) expansion are poorly documented in vivo. Prostaglandin F-2 alpha (PGF(2 alpha)) is a potent antiadipogenic factor in cultured preadipocytes, but evidence for its involvement in physiological context is lacking. We previously reported that Akr1b7, an aldo-keto reductase enriched in adipose stromal vascular fraction but absent from mature adipocytes, has antiadipogenic properties possibly supported by PGF(2 alpha) synthase activity. To test whether lack of Akr1b7 could influence WAT homeostasis in vivo, we generated Akr1b7(-/-) mice in 129/Sv background. Akr1b7(-/-) mice displayed excessive basal adiposity resulting from adipocyte hyperplasia/hypertrophy and exhibited greater sensitivity to diet-induced obesity. Following adipose enlargement and irrespective of the diet, they developed liver steatosis and progressive insulin resistance. Akr1b7 loss was associated with decreased PGF(2 alpha) WAT contents. Cloprostenol (PGF(2 alpha) agonist) administration to Akr1b7(-/-) normalized WAT expansion by affecting both de novo adipocyte differentiation and size. Treatment of 3T3-L1 adipocytes and Akr1b7(-/-) mice with cloprostenol suggested that decreased adipocyte size resulted from inhibition of lipogenic gene expression. Hence, Akr1b7 is a major regulator of WAT development through at least two PGF(2 alpha)-dependent mechanisms: inhibition of adipogenesis and lipogenesis. These findings provide molecular rationale to explore the status of aldo-keto reductases in dysregulations of adipose tissue homeostasis. Diabetes 61:2796-2806, 2012
C1 [Volat, Fanny E.; Pointud, Jean-Christophe; Pastel, Emilie; Lefrancois-Martinez, Anne-Marie; Martinez, Antoine] Clermont Univ, Ctr Natl Rech Sci, Unite Mixte Rech 6293, Inst Natl Sante & Rech Med,Genet Reprod & Dev U11, Aubiere, France.
   [Morio, Beatrice] Ctr Rech Nutr Humaine Auvergne, Inst Natl Rech Agron, Unite Mixte Rech 1019, Clermont Ferrand, France.
   [Sion, Benoit] Univ Auvergne, EA975, Fac Med, Clermont Ferrand, France.
   [Hamard, Ghislaine] Inst Cochin Genet Mol, F-75014 Paris, France.
   [Guichardant, Michel; Colas, Romain] Univ Lyon 1, Inst Multidisciplinaire Biochim Lipides, Inst Natl Rech Agron 1235, Inst Natl Sci Appl Lyon,U870,Inst Natl Sante Rech, F-69622 Villeurbanne, France.
C3 Centre National de la Recherche Scientifique (CNRS); Institut National
   de la Sante et de la Recherche Medicale (Inserm); Universite Clermont
   Auvergne (UCA); INRAE; Universite Clermont Auvergne (UCA); Institut
   National de la Sante et de la Recherche Medicale (Inserm); Universite
   Paris Cite; INRAE; Universite Claude Bernard Lyon 1; Institut National
   des Sciences Appliquees de Lyon - INSA Lyon; Institut National de la
   Sante et de la Recherche Medicale (Inserm)
RP Martinez, A (corresponding author), Clermont Univ, Ctr Natl Rech Sci, Unite Mixte Rech 6293, Inst Natl Sante & Rech Med,Genet Reprod & Dev U11, Aubiere, France.
EM antoine.martinez@univ-bpclermont.fr
RI Sion, Benoit/K-2268-2015; Morio, Béatrice/JCD-6492-2023; Morio,
   Beatrice/G-3571-2018
OI Pastel, Emilie/0000-0003-0390-4657; Morio, Beatrice/0000-0002-2418-1438
FU Centre National de la Recherche Scientifique; Universite Blaise Pascal;
   Universite d'Auvergne; Institut National de la Sante et de la Recherche
   Medicale
FX This work was supported by funds from the Centre National de la
   Recherche Scientifique, Universite Blaise Pascal, Universite d'Auvergne,
   and Institut National de la Sante et de la Recherche Medicale.
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NR 47
TC 34
Z9 41
U1 0
U2 18
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0012-1797
J9 DIABETES
JI Diabetes
PD NOV
PY 2012
VL 61
IS 11
BP 2796
EP 2806
DI 10.2337/db11-1297
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 050GQ
UT WOS:000312041600017
PM 22851578
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Conen, D
   Vollenweider, P
   Rousson, V
   Marques-Vidal, P
   Paccaud, F
   Waeber, G
   Bochud, M
AF Conen, David
   Vollenweider, Peter
   Rousson, Valentin
   Marques-Vidal, Pedro
   Paccaud, Fred
   Waeber, Gerard
   Bochud, Murielle
TI Use of A Mendelian Randomization Approach to Assess the Causal Relation
   of γ-Glutamyltransferase with Blood Pressure and Serum Insulin Levels
SO AMERICAN JOURNAL OF EPIDEMIOLOGY
LA English
DT Article
DE blood pressure; diabetes mellitus; gamma-glutamyltransferase; insulin;
   Mendelian randomization analysis; obesity
ID CARDIOVASCULAR-DISEASE MORTALITY; MIDDLE-AGED MEN; METABOLIC SYNDROME;
   LIVER-ENZYMES; ALANINE AMINOTRANSFERASE; TRANSPEPTIDASE LEVEL; OXIDATIVE
   STRESS; FASTING GLUCOSE; AUSTRIAN ADULTS; RISK
AB Elevated levels of gamma-glutamyltransferase (GGT) have been associated with elevated blood pressure (BP) and diabetes. However, the causality of these relations has not been addressed. The authors performed a cross-sectional analysis (2003-2006) among 4,360 participants from the population-based Cohorte Lausannoise (CoLaus) Study (Lausanne, Switzerland). The rs2017869 variant of the gamma-glutamyltransferase 1 (GGT1) gene, which explained 1.6% of the variance in GGT levels, was used as an instrument for Mendelian randomization (MR). Sex-specific GGT quartiles were strongly associated with both systolic and diastolic BP (all P's < 0.0001). After multivariable adjustment, these relations were attenuated but remained significant. Using MR, the authors observed no positive association of GGT with BP (systolic: beta -5.68, 95% confidence interval (CI): -11.51, 0.16 (P = 0.06); diastolic: beta = -2.24, 95% CI: -5.98, 1.49 (P = 0.24)). The association of GGT with insulin was also attenuated after multivariable adjustment but persisted in the fully adjusted model (beta = 0.07, 95% CI: 0.04, 0.09; P < 0.0001). Using MR, the authors also observed a positive association of GGT with insulin (beta = 0.19, 95% CI: 0.01, 0.37; P = 0.04). In conclusion, the authors found evidence for a direct causal relation of GGT with fasting insulin but not with BP.
C1 [Rousson, Valentin; Marques-Vidal, Pedro; Paccaud, Fred; Bochud, Murielle] CHU Vaudois, Inst Social & Prevent Med, CH-1015 Lausanne, Switzerland.
   [Vollenweider, Peter; Rousson, Valentin; Marques-Vidal, Pedro; Paccaud, Fred; Waeber, Gerard; Bochud, Murielle] Univ Lausanne, Lausanne, Switzerland.
   [Vollenweider, Peter; Waeber, Gerard] CHU Vaudois, Dept Med, CH-1015 Lausanne, Switzerland.
   [Conen, David] Univ Basel Hosp, Dept Med, CH-4031 Basel, Switzerland.
C3 University of Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV);
   University of Lausanne; University of Lausanne; Centre Hospitalier
   Universitaire Vaudois (CHUV); University of Basel
RP Bochud, M (corresponding author), CHU Vaudois, Inst Social & Prevent Med, CH-1015 Lausanne, Switzerland.
EM murielle.bochud@chuv.ch
RI Bochud, Murielle/A-3981-2010; paccaud, fred/M-7516-2019; Marques-Vidal,
   Pedro/C-9449-2009; Vollenweider, Peter/Q-4603-2016
OI Marques-Vidal, Pedro/0000-0002-4548-8500; Waeber,
   Gerard/0000-0003-4193-788X; Rousson, Valentin/0000-0001-8092-4446;
   Vollenweider, Peter/0000-0002-0765-896X
FU GlaxoSmithKline; Faculty of Biology and Medicine of the University of
   Lausanne; Swiss National Science Foundation [33CSCO-122661,
   3100AO-116323/1, 3200BO-111361/2]; Swiss School of Public Health Plus;
   University Hospital Basel
FX The CoLaus Study was supported financially by contributions from
   GlaxoSmithKline, the Faculty of Biology and Medicine of the University
   of Lausanne, and the Swiss National Science Foundation (grants
   33CSCO-122661 and 3100AO-116323/1). Dr. Murielle Bochud was supported by
   the Swiss National Science Foundation (grant 3200BO-111361/2) and the
   Swiss School of Public Health Plus. Dr. David Conen was supported by
   grants from University Hospital Basel.
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NR 38
TC 32
Z9 33
U1 2
U2 9
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0002-9262
J9 AM J EPIDEMIOL
JI Am. J. Epidemiol.
PD DEC 15
PY 2010
VL 172
IS 12
BP 1431
EP 1441
DI 10.1093/aje/kwq308
PG 11
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA 692ZA
UT WOS:000285193200014
PM 21044991
OA Bronze
DA 2025-06-11
ER

PT J
AU Faria, CDC
   Castro, RB
   Longui, CA
   Kochi, C
   Barbosa, VLP
   Silva, TSE
   Rocha, MN
   Melo, MR
   Monte, O
AF Costantin Faria, Claudia Dutra
   Castro, Roberta Borges
   Longui, Carlos Alberto
   Kochi, Cristiane
   Perino Barbosa, Vera Lucia
   Sousa e Silva, Tatiane
   Rocha, Mylene Neves
   Melo, Murilo Rezende
   Monte, Osmar
TI Impact of Prolonged Low-Grade Physical Training on the in vivo
   Glucocorticoid Sensitivity and on Glucocorticoid Receptor-α mRNA Levels
   of Obese Adolescents
SO HORMONE RESEARCH IN PAEDIATRICS
LA English
DT Article
DE Glucocorticoid sensitivity; Glucocorticoid receptor; Dexamethasone;
   Physical exercise; Obesity
ID PITUITARY-ADRENAL-AXIS; NF-KAPPA-B; INSULIN-RESISTANCE; METABOLIC
   SYNDROME; WAIST CIRCUMFERENCE; OXIDATIVE STRESS; SKELETAL-MUSCLE;
   EXERCISE; FAT; DEXAMETHASONE
AB Background/Aim: Healthy individuals present variable responses of the hypothalamic-pituitary-adrenal (HPA) axis induced by different patterns of physical training. The aim of this study was to evaluate whether prolonged low- grade physical training influences the HPA axis and also glucocorticoid receptor-alpha (GR alpha) mRNA levels in mononuclear cells of obese adolescents. Methods: We studied 19 patients with BMI above the 95th percentile (male: female ratio 7:12) aged from 9.5 to 15.5 years. Patients underwent a 12-week physical exercise program. Before and after exercise, in vivo glucocorticoid sensitivity was determined by employing a verylow-dose intravenous dexamethasone suppression test, and in vitro GR alpha mRNA levels were evaluated by quantitative real- time PCR. Results: After exercise there was a trend to reduce the in vivo glucocorticoid sensitivity (p = 0.071) and a significant increase in GR alpha mRNA levels (p = 0.025). Conclusion: For this subset of obese adolescents, prolonged low- grade physical training tended to reduce glucocorticoid sensitivity. The discrepancy of cortisol response to dexamethasone and the GR alpha mRNA measurement suggest a post-receptor phenomenon or should be related to target tissue-specific differences in glucocorticoid sensitivity. Future studies should address the adaptive GR alpha mRNA during different exercise protocols, and also the correlation of pituitary sensitivity with glucocorticoid target tissue sensitivity. Copyright (C) 2010 S. Karger AG, Basel
C1 [Costantin Faria, Claudia Dutra; Longui, Carlos Alberto; Kochi, Cristiane] Irmandade Santa Casa Misericordia Sao, Pediat Endocrinol Unit, Dept Pediat, Sao Paulo, Brazil.
   [Castro, Roberta Borges; Longui, Carlos Alberto; Kochi, Cristiane; Sousa e Silva, Tatiane; Rocha, Mylene Neves; Melo, Murilo Rezende; Monte, Osmar] Santa Casa Sao Paulo, Dept Physiol, Mol Med Lab, Fac Med Sci, Sao Paulo, Brazil.
   [Perino Barbosa, Vera Lucia] Movere Inst Community Act, Sao Paulo, Brazil.
C3 Universidade Federal de Sao Paulo (UNIFESP)
RP Faria, CDC (corresponding author), Santa Casa Sao Paulo, Pediat Endocrinol, Marques de Itu 977,Ap 122, BR-01223001 Sao Paulo, Brazil.
EM ceclau@terra.com.br
RI Longui, Carlos/B-8112-2013; Sousa e Silva, Tatiane/B-7862-2013; Melo,
   Murilo/F-4255-2012; Rocha, Mylene/F-4211-2012; Monte, Osmar/G-9063-2012
OI Melo, Murilo/0000-0003-1105-5384; Silva, Tatiane/0000-0002-9254-7411;
   Monte, Osmar/0000-0002-2549-9237
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NR 46
TC 3
Z9 3
U1 0
U2 1
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1663-2818
EI 1663-2826
J9 HORM RES PAEDIAT
JI Horm. Res. Paediatr.
PY 2010
VL 73
IS 6
BP 458
EP 464
DI 10.1159/000313591
PG 7
WC Endocrinology & Metabolism; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Pediatrics
GA 594WM
UT WOS:000277570200006
PM 20407233
DA 2025-06-11
ER

PT J
AU Luyendyk, JP
   Sullivan, BP
   Guo, GL
   Wang, RP
AF Luyendyk, James P.
   Sullivan, Bradley P.
   Guo, Grace L.
   Wang, Ruipeng
TI Tissue Factor-Deficiency and Protease Activated Receptor-1-Deficiency
   Reduce Inflammation Elicited by Diet-Induced Steatohepatitis in Mice
SO AMERICAN JOURNAL OF PATHOLOGY
LA English
DT Article
ID FATTY LIVER-DISEASE; FACTOR GENE-EXPRESSION; NONALCOHOLIC
   STEATOHEPATITIS; METHIONINE-DEFICIENT; METABOLIC SYNDROME;
   BLOOD-COAGULATION; OXIDATIVE STRESS; KUPFFER CELLS; MURINE MODEL;
   FIBROSIS
AB Altered hepatic lipid homeostasis, hepatocellular injury, and inflammation are features of nonalcoholic steatohepatitis, which contributes significantly to liver-related morbidity and mortality in the Western population. A collection of inflammatory mediators; have been implicated in the pathogenesis of steatohepatitis in mouse models. However, the pathways essential for coordination and amplification of hepatic inflammation and injury caused by steatosis are not completely understood. We tested the hypothesis that tissue factor (TF)-dependent thrombin generation and the thrombin receptor protease activated receptor-1 (PAR-1) contribute to liver inflammation induced by steatosis in mice. Wild-type C57B1/6J mice fed a diet deficient in methionine and choline for 2 weeks manifested steatohepatitis characterized by increased serum alanine aminotransferase activity, macrovesicular hepatic steatosis, hepatic inflammatory gene expression, and lobular inflammation. Steatohepatitis progression was associated with thrombin generation and hepatic fibrin deposition. Coagulation cascade activation was significantly reduced in low TF mice, which express 1% of normal TF levels. Hepatic triglyceride accumulation was not affected in low TF mice or PAR-1-deficient mice. In contrast, biomarkers of hepatocellular injury, inflammatory gene induction, and hepatic accumulation of macrophages and neutrophils were greatly reduced by TF-deficiency and PAR-1-deficiency. The results suggest that TF-dependent thrombin generation and activation of PAR-1 amplify hepatic inflammation and injury during the pathogenesis of steatohepatitis. (Am J Pathol 2010,176:177-186; DOI: 10.2353/ajpath.2010.090672)
C1 [Luyendyk, James P.; Sullivan, Bradley P.; Guo, Grace L.] Univ Kansas, Med Ctr, Dept Pharmacol Toxicol & Therapeut, Kansas City, KS 66160 USA.
C3 University of Kansas; University of Kansas Medical Center
RP Luyendyk, JP (corresponding author), Univ Kansas, Med Ctr, Dept Pharmacol Toxicol & Therapeut, 3901 Rainbow Blvd,MS-1018, Kansas City, KS 66160 USA.
EM jluyendyk@kumc.edu
RI wang, ruipeng/LBH-3184-2024
FU American Heart Association Scientist Development [0835121G]; National
   Institutes of Health [P20 RR021940, RO1DK081343]; American Heart
   Association (AHA) [0835121G] Funding Source: American Heart Association
   (AHA)
FX Supported by American Heart Association Scientist Development grant
   0835121G (J.P.L.) and by the National Institutes of Health P20 RR021940
   (J.P.L.) and RO1DK081343 (G.L.G.).
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NR 58
TC 41
Z9 51
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0002-9440
EI 1525-2191
J9 AM J PATHOL
JI Am. J. Pathol.
PD JAN
PY 2010
VL 176
IS 1
BP 177
EP 186
DI 10.2353/ajpath.2010.090672
PG 10
WC Pathology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pathology
GA 550EN
UT WOS:000274111200019
PM 20008134
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Holguin, F
   Rojas, M
   Hart, CM
AF Holguin, Fernando
   Rojas, Mauricio
   Hart, C. Michael
TI The peroxisome proliferator activated receptor gamma (PPARγ) ligand
   rosiglitazone modulates bronchoalveolar lavage levels of leptin,
   adiponectin, and inflammatory cytokines in lean and obese mice
SO LUNG
LA English
DT Article
DE PPAR; obesity; asthma; Leptin; adiponectin
ID ALLERGIC AIRWAY INFLAMMATION; GM-CSF; OXIDATIVE STRESS; INCREASES
   ADIPONECTIN; METABOLIC SYNDROME; ASTHMA MODEL; HYPERRESPONSIVENESS;
   RESPONSES; AGONISTS; PLASMA
AB Obese mice that lack leptin receptor (db(-)/db(-)) have been shown to have innate bronchial hyperresponsiveness (BHR). It has been proposed that the obesity-mediated BHR may involve a combination of increased leptin and reduced systemic adiponectin levels. The aim of this study was to determine if obesity modifies the airway concentration of leptin and adiponectin and whether treatment with a synthetic peroxisome proliferator-activated receptor gamma (PPAR gamma) ligand can reduce airway leptin and increase airway adiponectin. In this study, obese, leptin receptor-deficient (db(-)/db-), or lean (db(+)/db(-)) mice were treated with rosiglitazone (3 mg/kg/day) or vehicle by gavage daily for 1 week. Bronchioalveolar lavage (BAL) was subsequently performed to determine levels of leptin, adiponectin, and inflammatory cytokines. Treatment with rosiglitazone increased BAL adiponectin levels in lean (p = 0.04) and to a lesser extent in obese mice (p = 0.07). Rosiglitazone treatment lowered leptin levels in lean mice, but increased leptin levels in BAL fluid of obese mice (p < 0.01). The BAL levels of granulocyte-macrophage colony-stimulating factor (GM-CSF) were lower in the lean rosiglitazone-treated group compared with the obese vehicle-treated group and lower in the obese rosiglitazone-treated group compared with the obese vehicle-treated group. These results demonstrate that obesity is associated with alterations in adipokine and cytokine levels in the airways that can be modulated by treatment with roziglitazone.
C1 Clin Res Ctr, Atlanta, GA 30308 USA.
   Emory Univ, Atlanta Vet Affairs Med Ctr, Atlanta, GA 30308 USA.
C3 Emory University; US Department of Veterans Affairs; Veterans Health
   Administration (VHA); Atlanta VA Health Care System
RP Holguin, F (corresponding author), Clin Res Ctr, Davis Fisher Bldg, 550 Peachtree St NE, 2nd Fl,Rm, Atlanta, GA 30308 USA.
EM fch5@cdc.gov
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NR 40
TC 17
Z9 19
U1 0
U2 1
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0341-2040
EI 1432-1750
J9 LUNG
JI Lung
PD DEC
PY 2007
VL 185
IS 6
BP 367
EP 372
DI 10.1007/s00408-007-9035-9
PG 6
WC Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Respiratory System
GA 232ED
UT WOS:000251000200008
PM 17909895
DA 2025-06-11
ER

PT J
AU Syed, AH
   Lohana, S
   Aung, NH
   Memon, MK
   Shaikh, A
   Memon, S
   Hassan, SM
   Kumar, B
AF Syed, Asghar Hussain
   Lohana, Sameer
   Aung, Norah H.
   Memon, Muhammad Khizar
   Shaikh, Anam
   Memon, Sidra
   Hassan, Syeda M.
   Kumar, Besham
TI Correlation of Leptin With Acute Myocardial Infarction: A Case Control
   Study
SO CUREUS JOURNAL OF MEDICAL SCIENCE
LA English
DT Article
DE leptin; acute myocardial infarction; pakistan
ID METABOLIC SYNDROME; RISK
AB Introduction: Leptin, a satiety hormone, has the ability to inhibit hunger and is thus, a regulator of body weight. Leptin is also elevated in cardiovascular events such as acute myocardial infarction (AMI) and hence is considered as modifiable risk factors for AMI. The purpose of this study is therefore to investigate the correlation of leptin with AMI.
   Methodology: In this retrospective study, data of patients were taken from the database between January 2017 to December 2019 from a cardiovascular unit of tertiary care hospital in Pakistan. Patients were divided into two groups, based on participants who had suffered from AMI and other groups who had not suffered an AMI. Leptin levels were compared for both groups. Age, body mass index (BMI), and smoking history were noted in a self-structured questionnaire. In addition, mean blood pressure and cholesterol levels were also noted for both groups.
   Results: Leptin was significantly higher in patients with first time AMI (29.21 +/- 9.21 ng/mL vs. 11.23 +/- 3.12 ng/mL: p-value, <0.0001). BMI (27.2 +/- 3.2 kg/m(2) vs. 24.9 +/- 2.8 kg/m(2) : p-value, <0.0001) and percentage of smokers (40.9% vs. 22.9%: p-value, 0.032) were also significantly higher in patients with AMI.
   Conclusion: A positive correlation was found between AMI and serum leptin levels in smokers and obese patients. Hence, we suggest that cardiologists should stress upon controlling these modifiable risk factors to reduce the incidence of AMI in the future.
C1 [Syed, Asghar Hussain] Royal Coll Physicians, Internal Med, London, England.
   [Syed, Asghar Hussain] Natl Inst Cardiovasc Dis, Cardiol, Karachi, Pakistan.
   [Syed, Asghar Hussain] Ziauddin Univ, Family Med, Karachi, Pakistan.
   [Lohana, Sameer] Liaquat Univ Med & Hlth Sci, Med, Karachi, Pakistan.
   [Aung, Norah H.] Western Illinois Univ, Hlth Sci, Macomb, IL 61455 USA.
   [Aung, Norah H.] Univ Med 1, Internal Med, Yangon, Myanmar.
   [Memon, Muhammad Khizar] Liaquat Univ Med & Hlth Sci, Internal Med, Hyderabad, India.
   [Shaikh, Anam] Dow Univ Hlth Sci, Internal Med, Karachi, Pakistan.
   [Memon, Sidra] Jinnah Sindh Med Univ, Internal Med, Karachi, Pakistan.
   [Hassan, Syeda M.] Jinnah Sindh Med Univ, Med, Karachi, Pakistan.
   [Kumar, Besham] Jinnah Postgrad Med Ctr, Internal Med, Karachi, Pakistan.
C3 Royal College of Physicians; Ziauddin University; Liaquat University of
   Medical & Health Sciences; Western Illinois University; Dow University
   of Health Sciences; Jinnah Sindh Medical University - Pakistan; Jinnah
   Sindh Medical University - Pakistan
RP Kumar, B (corresponding author), Jinnah Postgrad Med Ctr, Internal Med, Karachi, Pakistan.
EM beshamkumar916@gmail.com
RI Hassan, Maria/IYJ-5337-2023
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NR 24
TC 3
Z9 3
U1 0
U2 0
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
EI 2168-8184
J9 CUREUS J MED SCIENCE
JI Cureus J Med Sci
PD DEC 20
PY 2020
VL 12
IS 12
AR e12190
DI 10.7759/cureus.12190
PG 4
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA PL1WT
UT WOS:000602921600012
PM 33489600
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Yang, PK
   Chou, CH
   Chang, CH
   Chen, SU
   Ho, HN
   Chen, MJ
AF Yang, Po-Kai
   Chou, Chia-Hong
   Chang, Chin-Hao
   Chen, Shee-Uan
   Ho, Hong-Nerng
   Chen, Mei-Jou
TI Changes in peripheral mitochondrial DNA copy number in metformin-treated
   women with polycystic ovary syndrome: a longitudinal study
SO REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
LA English
DT Article
DE Humans; Female; Polycystic ovary syndrome; Testosterone; Metformin; DNA
   mitochondrial; 8-Hydroxy-2 '-Deoxyguanosine
ID OXIDATIVE STRESS; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   HYPERANDROGENEMIA; TESTOSTERONE; DYSFUNCTION; LEUKOCYTES; DECREASES;
   MENSES; BLOOD
AB Background: Patients with polycystic ovarian syndrome (PCOS) are associated with known alterations in mitochondria DNA copy number (mtDNA-CN). The aim of this study is to study the change in mtDNA-CN in patients with PCOS who were treated with metformin.
   Methods: This is a prospective cohort of patients with PCOS, who received metformin for one year. From 2009 to 2015, 88 women diagnosed with PCOS, based on the Rotterdam criteria, were enrolled. Serial measurements of mtDNA-CN, 8-hydroxydeoxyguanosine (8-OHdG), anthropometric, metabolic, endocrine, and inflammatory markers were obtained before and after 3, 6, and 12 months of treatment.
   Results: A significant decrease in mtDNA-CN was seen over the course of one year. Other markers, including 8-OHdG, testosterone, free androgen index, blood pressure and liver enzymes, also decreased in the same interval. On regression analysis, there was a significant association between the change in mtDNA-CN and serum total testosterone, and no association between mtDNA-CN and metabolic factors.
   Conclusions: Treatment with metformin is associated with a time-dependent decrease in mtDNA-CN in patients with PCOS who are treated over the course of one year. This may signify a reduction in mitochondria dysfunction. The change in mtDNA-CN corresponds to a similar change in serum total testosterone, and suggests a possible relationship between mtDNA-CN and testosterone.
C1 [Yang, Po-Kai; Chou, Chia-Hong; Chen, Shee-Uan; Ho, Hong-Nerng; Chen, Mei-Jou] Natl Taiwan Univ Hosp, Dept Obstet & Gynecol, 8 Chung Shan South Rd, Taipei 100, Taiwan.
   [Yang, Po-Kai; Chen, Shee-Uan; Ho, Hong-Nerng; Chen, Mei-Jou] Natl Taiwan Univ, Coll Med, Taipei, Taiwan.
   [Chang, Chin-Hao] Natl Taiwan Univ Hosp, Dept Med Res, Taipei, Taiwan.
   [Ho, Hong-Nerng] Taipei Med Univ, Coll Med, Taipei, Taiwan.
   [Chen, Mei-Jou] Natl Taiwan Univ, Taipei, Taiwan.
C3 National Taiwan University; National Taiwan University Hospital;
   National Taiwan University; National Taiwan University; National Taiwan
   University Hospital; Taipei Medical University; National Taiwan
   University
RP Chen, MJ (corresponding author), Natl Taiwan Univ Hosp, Dept Obstet & Gynecol, 8 Chung Shan South Rd, Taipei 100, Taiwan.; Chen, MJ (corresponding author), Natl Taiwan Univ, Coll Med, Taipei, Taiwan.; Chen, MJ (corresponding author), Natl Taiwan Univ, Taipei, Taiwan.
EM mjchen04@ntu.edu.tw
RI Chen, Mei-Jou/AAS-7698-2020; Chien, Sheng-Hsuan/HDM-2486-2022; NTU,
   Ref07/AAX-7890-2021
OI CHEN, SHEE-UAN/0000-0001-7592-3238; Ho, Hong-Nerng/0000-0002-7207-0089;
   CHEN, MEI-JOU/0000-0002-2305-1105; Yang, Pokai/0000-0003-1818-5309
FU Ministry of Science and Technology of Taiwan [MOST
   105-2628-B002-043-MY4]
FX The study was supported by the Ministry of Science and Technology of
   Taiwan (MOST 105-2628-B002-043-MY4).
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NR 47
TC 20
Z9 20
U1 0
U2 5
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1477-7827
J9 REPROD BIOL ENDOCRIN
JI Reprod. Biol. Endocrinol.
PD JUL 13
PY 2020
VL 18
IS 1
AR 69
DI 10.1186/s12958-020-00629-5
PG 10
WC Endocrinology & Metabolism; Reproductive Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Reproductive Biology
GA MQ3KR
UT WOS:000552796200001
PM 32660613
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU da Silva, BP
   Toledo, RCL
   Grancieri, M
   Moreira, MED
   Medina, NR
   Silva, RR
   Costa, NMB
   Martino, HSD
AF da Silva, Barbara Pereira
   Lopes Toledo, Renata Celi
   Grancieri, Mariana
   de Castro Moreira, Maria Eliza
   Medina, Natalia Ramirez
   Silva, Roberta Ribeiro
   Brunoro Costa, Neuza Maria
   Duarte Martino, Hercia Stampini
TI Effects of chia (Salvia hispanica L.) on calcium bioavailability
   and inflammation in Wistar rats
SO FOOD RESEARCH INTERNATIONAL
LA English
DT Article
DE Anti-inflammatory; Protein levels; Gene expression; NF kappa B;
   PPAR-alpha; Salvia hispanica L
ID HIGH-FAT DIET; INSULIN-RESISTANCE; METABOLIC SYNDROME; GENE-EXPRESSION;
   RISK-FACTORS; VITAMIN-D; ACID; SEED; RICH; SUPPLEMENTATION
AB Chia is a good source of calcium, however it is not been previously reported its bioavailability associated with an inflammatory condition. Thus, the present study evaluated the effect of chia on calcium bioavailability, inflammation, and oxidative stress in Wistar rats fed a high-fat diet or standard diet for 35 days. Chia consumption resulted in lower calcium balance and calcium absorption and retention rates. In addition, the urinary calcium concentration was lower in groups that were fed chia. The bone resistance of animals feed chia was lower than that in rats fed the standard diet receiving calcium carbonate. Animals that were fed chia showed lower total, very low-density lipoprotein, and low-density lipoprotein cholesterol levels than animalsfed calcium carbonate. Animals fed standard diet showed higher superoxide dismutase plasma concentrations than animals in the high fat calcium carbonate group. PPAR-alpha protein levels were higher in animals fed chia whereas TNF-alpha and IL-10 were lower in these animals. NF kappa B mRNA expression and protein levels were lower in the groups that received this compared with HFD + CC. Chia intake presented low calcium bioavailability regardless of the type of diet consumed and was able to improved inflammation and the lipid profile in young Wistar rat. Besides this, the consumption of this seed increased the activity of antioxidants enzymes.
C1 [da Silva, Barbara Pereira; Lopes Toledo, Renata Celi; Grancieri, Mariana; de Castro Moreira, Maria Eliza; Duarte Martino, Hercia Stampini] Univ Fed Vicosa, Dept Nutr & Hlth, Av Purdue S-N,Campus Univ, BR-36570900 Vicosa, MG, Brazil.
   [Medina, Natalia Ramirez] Univ Fed Vicosa, Dept Biochem, Av Purdue S-N,Campus Univ, BR-36570900 Vicosa, MG, Brazil.
   [Silva, Roberta Ribeiro] Univ Fed Alfenas, Dept Nutr, BR-37130000 Alfenas, Brazil.
   [Brunoro Costa, Neuza Maria] Univ Fed Espirito Santo, Dept Nutr, Alto Univ S-N, BR-29500000 Alegre, ES, Brazil.
C3 Universidade Federal de Vicosa; Universidade Federal de Vicosa;
   Universidade Federal de Alfenas; Universidade Federal do Espirito Santo
RP da Silva, BP (corresponding author), Univ Fed Vicosa, Dept Nutr & Hlth, Av Purdue S-N,Campus Univ, BR-36570900 Vicosa, MG, Brazil.
EM barbarapereira2805@gmail.com
RI Grancieri, Mariana/D-1225-2018; Silva, Barbara/NKO-7601-2025
OI da Silva, Barbara Pereira/0000-0003-1096-456X; Stampini Duarte Martino,
   Hercia/0000-0002-8565-8439
FU Foundation for Research Support of Minas Gerais (FAPEMIG, Brazil)
FX The authors would like to thank the Foundation for Research Support of
   Minas Gerais (FAPEMIG, Brazil) for financial support of the research; we
   are also grateful to the Coordination for the Improvement of Higher
   Education Personnel (CAPES, Brazil), and the National Counsel of
   Technological and Scientific Development (CNPq, Brazil).
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NR 52
TC 35
Z9 36
U1 0
U2 12
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0963-9969
EI 1873-7145
J9 FOOD RES INT
JI Food Res. Int.
PD FEB
PY 2019
VL 116
BP 592
EP 599
DI 10.1016/j.foodres.2018.08.078
PG 8
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA HL7TC
UT WOS:000458942900065
PM 30716985
OA Green Published
DA 2025-06-11
ER

PT J
AU Gonçalves, JL
   Lacerda-Queiroz, N
   Sabino, JFL
   Marques, PE
   Galvao, I
   Gamba, CO
   Cassali, GD
   de Carvalho, LM
   Silva, DADE
   Versiani, A
   Teixeira, MM
   de Faria, AMC
   Vieira, AT
   Brunialti-Godard, AL
AF Goncalves, Juliana L.
   Lacerda-Queiroz, Norinne
   Sabino, Josiane F. L.
   Marques, Pedro E.
   Galvao, Izabela
   Gamba, Conrado O.
   Cassali, Geovanni D.
   de Carvalho, Luana M.
   da Silva e Silva, Daniel Almeida
   Versiani, Adaliene
   Teixeira, Mauro M.
   de Faria, Ana Maria Caetano
   Vieira, Angelica T.
   Brunialti-Godard, Ana Lucia
TI Evaluating the effects of refined carbohydrate and fat diets with acute
   ethanol consumption using a mouse model of alcoholic liver injury
SO JOURNAL OF NUTRITIONAL BIOCHEMISTRY
LA English
DT Article
DE Alcoholic liver disease; Liver; Ethanol; Diet; Inflammation; Mice
ID NONALCOHOLIC STEATOHEPATITIS; METABOLIC SYNDROME; HEPATIC STEATOSIS;
   DISEASE; MICE; INFLAMMATION; STRESS; EPIDEMIOLOGY; PATHOGENESIS;
   PROGRESSION
AB Alcoholism is a multifactorial and complex disorder responsible for 5.9% of deaths worldwide. Excessive consumption of ethanol (Et-OH) induces alcoholic liver disease (ALD), a condition comprising a spectrum of clinical signs and morphological changes, ranging from fatty liver (steatosis) to more severe forms of chronic liver injury. Secondary cofactors, such as nutritional and hepatotoxic comorbid conditions, can also contribute to liver disease development. Here we investigated the effects in the progression of ALD following short-term exposure to diet high in refined carbohydrates (HC), a high-sugar and-butter (HSB) hypercaloric diet and acute Et-OH consumption. HSB diet increased the body weight (BW) and adiposity independently of acute Et-OH consumption. HC diet did not affect BW but increased the adiposity, while acute Et-OH alone did not affect BW and adiposity. All groups of mice developed steatosis except the control group. Exposure to acute Et-OH and HSB diet increased the number of neutrophils and macrophages, and apoptosis in the liver. This combination also increased the number of circulating neutrophils and reduced mononuclear cells in the blood. Thus, short-term exposure to HSB diet and acute Et-OH intake is linked to increased liver injury. These findings offer important clues to understand the hepatic injuries associated with short exposure to hypercaloric diets and acute Et-OH. (C) 2016 Elsevier Inc. All rights reserved.
C1 [Goncalves, Juliana L.; Lacerda-Queiroz, Norinne; de Carvalho, Luana M.; da Silva e Silva, Daniel Almeida; Vieira, Angelica T.; Brunialti-Godard, Ana Lucia] Dept Biol Geral, Belo Horizonte, MG, Brazil.
   [Goncalves, Juliana L.; Lacerda-Queiroz, Norinne; Sabino, Josiane F. L.; Marques, Pedro E.; Galvao, Izabela; Teixeira, Mauro M.; de Faria, Ana Maria Caetano; Vieira, Angelica T.] Dept Bioquim & Imunol, Belo Horizonte, MG, Brazil.
   [Gamba, Conrado O.; Cassali, Geovanni D.] Inst Ciencias Biol, Dept Patol Geral, Belo Horizonte, MG, Brazil.
   [Versiani, Adaliene] Univ Fed Minas Gerais, Escola Enfermagem, Dept Nutr, Belo Horizonte, MG, Brazil.
   [Goncalves, Juliana L.] Fundacao Oswaldo Cruz, Inst Nacl Infectol Evandro Chagas INI, Rio De Janeiro, Rio De Janeiro, Brazil.
C3 Universidade Federal de Minas Gerais; Fundacao Oswaldo Cruz
RP Vieira, AT; Brunialti-Godard, AL (corresponding author), Univ Fed Minas Gerais, Inst Ciencias Biol, Dept Biol Geral, BR-31270901 Belo Horizonte, MG, Brazil.
EM angelicathomaz@gmail.com; anagodard@hotmail.com
RI souza, danielle/D-3378-2014; Marques, Pedro/U-5740-2019; Carvalho,
   Luana/AAF-9838-2021; Brunialti Godard, Ana Lúcia/U-5155-2019; Lauar
   Goncalves, Juliana/B-5143-2013; Cassali, Geovanni/A-4535-2008; Vieira,
   Angelica/A-6227-2015; Teixeira, Mauro/A-4587-2008
OI Lauar Goncalves, Juliana/0000-0002-3818-922X; Cassali,
   Geovanni/0000-0002-5650-6743; Vieira, Angelica/0000-0002-4556-7671;
   Carvalho, Luana/0000-0001-6063-7140; Brunialti Godard, Ana
   Lucia/0000-0001-5719-8802; Teixeira, Mauro/0000-0002-6944-3008; da
   Silva, Daniel/0000-0003-0033-3270; Faria, Ana Maria/0000-0002-0604-8510;
   Marques, Pedro Elias/0000-0002-5613-8012
FU Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq);
   Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (PNPD/CAPES)
   [23038.005051/2012-48]; Fundacao de Amparo e Pesquisa de Minas Gerais
   (FAPEMIG) [APQ-02,285-14]
FX This work was supported by the Conselho Nacional de Desenvolvimento
   Cientifico e Tecnologico (CNPq), the Coordenacao de Aperfeicoamento de
   Pessoal de Nivel Superior (PNPD/CAPES; 23038.005051/2012-48) and the
   Fundacao de Amparo e Pesquisa de Minas Gerais (FAPEMIG; APQ-02,285-14).
   CNPq, CAPES and FAPEMIG had no role in the design, analysis or writing
   of this article. This manuscript was reviewed by a professional science
   editor and by a native English-speaking copy editor to improve
   readability.
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NR 48
TC 23
Z9 24
U1 0
U2 25
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0955-2863
EI 1873-4847
J9 J NUTR BIOCHEM
JI J. Nutr. Biochem.
PD JAN
PY 2017
VL 39
BP 93
EP 100
DI 10.1016/j.jnutbio.2016.08.011
PG 8
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA EE4IT
UT WOS:000389566200011
PM 27821289
DA 2025-06-11
ER

PT J
AU Develi-Is, S
   Ozen, G
   Bekpinar, S
   Topal, G
   Unlucerci, Y
   Dogan, BSU
   Uysal, M
AF Develi-Is, Seval
   Ozen, Gulsev
   Bekpinar, Seldag
   Topal, Gokce
   Unlucerci, Yesim
   Dogan, B. Sonmez Uydes
   Uysal, Mujdat
TI Resveratrol improves high-fructose-induced vascular dysfunction in rats
SO CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
LA English
DT Article
DE high fructose; resveratrol; vascular function; asymmetric
   dimethylarginine; arginine; sirtuin; leptin
ID HEPATIC OXIDATIVE STRESS; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   ASYMMETRIC DIMETHYLARGININE; ENDOTHELIAL FUNCTION; NADPH OXIDASE;
   LEPTIN; ATTENUATION; EXPRESSION; ALPHA
AB High levels of fructose in the diet results in metabolic abnormalities and vascular disorders. In this study, the effect of resveratrol (RES) on vascular relaxation and contraction responses was examined in the aorta of high-fructose (HFr)-fed rats. mRNA expressions of aortic sirtuin 1 (SIRT1), GLUT5, and aldolase B were also investigated. Rats were given fructose (30%) and (or) RES (50 mg.L-1) in their drinking water for 8 weeks. In the HFr-fed rats, plasma levels of arginine and the ratio of arginine: asymmetric dimethylarginine (ADMA) decreased, whereas leptin levels increased. Decreased relaxation and increased contractile responses were detected in aortic rings. However, the aortic expressions of SIRT1, GLUT5, and aldolase B remained unchanged. RES treatment restored HFr-induced vascular dysfunction without improvements in insulin resistance. Treatment of HFr-fed rats with RES increased plasma levels of arginine and the L-arginine: ADMA ratio, and decreased plasma levels of leptin. RES increased SIRT1 expression, but decreased the expression of GLUT5 and aldolase B in aortas from HFr-fed rats. These results suggest that RES contributes to the restoration of HFr-induced vascular dysfunction in rats, at least in part, by up-regulation of SIRT 1 and down-regulation of GLUT5 and aldolase B in the aorta. Moreover, RES may have a positive influence on vasculature by partly restoring the plasma arginine: ADMA ratio and leptin levels.
C1 [Develi-Is, Seval; Bekpinar, Seldag; Unlucerci, Yesim; Uysal, Mujdat] Istanbul Univ, Istanbul Fac Med, Dept Biochem, TR-34093 Istanbul, Turkey.
   [Ozen, Gulsev; Topal, Gokce; Dogan, B. Sonmez Uydes] Istanbul Univ, Fac Pharm, Dept Pharmacol, TR-34116 Istanbul, Turkey.
C3 Istanbul University; Istanbul University
RP Bekpinar, S (corresponding author), Istanbul Univ, Istanbul Fac Med, Dept Biochem, TR-34093 Istanbul, Turkey.
EM seldabekpinar@hotmail.com
RI Dogan, B./AAD-7118-2020; Ozen, Gulsev/AAD-4984-2020; Bekpinar,
   Seldag/AAD-9066-2020
FU Istanbul University [35105]
FX This work was supported by the Research Fund of Istanbul University,
   project no: 35105. Conflict of interest: The authors have declared that
   there is no conflict of interest associated with this work.
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NR 50
TC 7
Z9 7
U1 1
U2 18
PU CANADIAN SCIENCE PUBLISHING
PI OTTAWA
PA 65 AURIGA DR, SUITE 203, OTTAWA, ON K2E 7W6, CANADA
SN 0008-4212
EI 1205-7541
J9 CAN J PHYSIOL PHARM
JI Can. J. Physiol. Pharmacol.
PD DEC
PY 2014
VL 92
IS 12
BP 1021
EP 1027
DI 10.1139/cjpp-2014-0245
PG 7
WC Pharmacology & Pharmacy; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Physiology
GA AU4DG
UT WOS:000345558600006
PM 25392295
DA 2025-06-11
ER

PT J
AU Castrogiovanni, D
   Alzamendi, A
   Ongaro, L
   Giovambattista, A
   Gaillard, RC
   Spinedi, E
AF Castrogiovanni, Daniel
   Alzamendi, Ana
   Ongaro, Luisina
   Giovambattista, Andres
   Gaillard, Rolf C.
   Spinedi, Eduardo
TI Fructose Rich Diet-Induced High Plasminogen Activator Inhibitor-1
   (PAI-1) Production in the Adult Female Rat: Protective Effect of
   Progesterone
SO NUTRIENTS
LA English
DT Article
DE high carbohydrate diet; glucose tolerance; insulin; adipokines;
   allostasis
ID ADIPOSE-TISSUE; INSULIN-RESISTANCE; OXIDATIVE STRESS; METABOLIC
   SYNDROME; FETAL LIPOGENESIS; HORMONE-THERAPY; DOUBLE-BLIND; INTACT RAT;
   SENSITIVITY; DYSFUNCTION
AB The effect of progesterone (P4) on fructose rich diet (FRD) intake-induced metabolic, endocrine and parametrial adipose tissue (PMAT) dysfunctions was studied in the adult female rat. Sixty day-old rats were i.m. treated with oil alone (control, CT) or containing P4 (12 mg/kg). Rats ate Purina chow-diet ad libitum throughout the entire experiment and, between 100 and 120 days of age drank ad libitum tap water alone (normal diet; CT-ND and P4-ND) or containing fructose (10% w/v; CT-FRD and P4-FRD). At age 120 days, animals were subjected to a glucose tolerance test or decapitated. Plasma concentrations of various biomarkers and PMAT gene abundance were monitored. P4-ND (vs. CT-ND) rats showed elevated circulating levels of lipids. CT-FRD rats displayed high (vs. CT-ND) plasma concentrations of lipids, leptin, adiponectin and plasminogen activator inhibitor-1 (PAI-1). Lipidemia and adiponectinemia were high (vs. P4-ND) in P4-FRD rats. Although P4 failed to prevent FRD-induced hyperleptinemia, it was fully protective on FRD-enhanced plasma PAI-1 levels. PMAT leptin and adiponectin mRNAs were high in CT-FRD and P4-FRD rats. While FRD enhanced PMAT PAI-1 mRNA abundance in CT rats, this effect was absent in P4 rats. Our study supports that a preceding P4-enriched milieu prevented the enhanced prothrombotic risk induced by FRD-elicited high PAI-1 production.
C1 [Castrogiovanni, Daniel; Alzamendi, Ana; Ongaro, Luisina; Giovambattista, Andres; Spinedi, Eduardo] IMBICE CONICET CICPBA, Neuroendocrine Unit, RA-1900 La Plata, Buenos Aires, Argentina.
   [Gaillard, Rolf C.] Univ Hosp CHUV, Div Endocrinol, CH-1011 Lausanne, Switzerland.
C3 Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET);
   University of Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV)
RP Spinedi, E (corresponding author), IMBICE CONICET CICPBA, Neuroendocrine Unit, RA-1900 La Plata, Buenos Aires, Argentina.
EM dcastrogiovanni@imbice.org.ar; anitaalzamendi@yahoo.com.ar;
   ongaroluisina@imbice.org.ar; agiovamba@imbice.org.ar;
   rolf.gaillard@chuv.ch; spinedi@imbice.org.ar
RI Spinedi, Eduardo/F-2455-2016
OI Alzamendi, Ana/0000-0003-4126-1103
FU National Research Council (CONICET) of Argentina [PIP 2009-0704];
   National Fond for Science and Technology (FONCyT) of Argentina [PICT
   2007-1051]; Fondation Pour la Recherche en Endocrinologie, Diabetologie
   et Metabolisme (FPREDM) of Switzerland
FX This work was partly supported by grants from the National Research
   Council (CONICET; PIP 2009-0704) and National Fond for Science and
   Technology (FONCyT; PICT 2007-1051) of Argentina, and Fondation Pour la
   Recherche en Endocrinologie, Diabetologie et Metabolisme (FPREDM
   2011-2012; to ES) of Switzerland. Authors wish to thank J.J. Gagliardino
   for his criticisms, and S. H. Rogers for correcting the manuscript.
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NR 42
TC 8
Z9 8
U1 0
U2 3
PU MDPI AG
PI BASEL
PA POSTFACH, CH-4005 BASEL, SWITZERLAND
SN 2072-6643
J9 NUTRIENTS
JI Nutrients
PD AUG
PY 2012
VL 4
IS 8
BP 1137
EP 1150
DI 10.3390/nu4081137
PG 14
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 998BG
UT WOS:000308211600017
PM 23016136
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Ludwig, DS
AF Ludwig, David S.
TI Weight Loss Strategies for Adolescents A 14-Year-Old Struggling to Lose
   Weight
SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
LA English
DT Article
ID BODY-MASS INDEX; CORONARY-HEART-DISEASE; QUALITY-OF-LIFE;
   PHYSICAL-ACTIVITY; CHILDHOOD OBESITY; METABOLIC SYNDROME; US CHILDREN;
   OVERWEIGHT ADOLESCENTS; CARDIOVASCULAR-DISEASE; PEDIATRIC OBESITY
AB With prevalence approaching 20% in the United States, adolescent obesity has become a common problem for patients, parents, and clinicians. Obese adolescents may experience physical and psychosocial complications, as illustrated by the case of Ms K, a 14-year-old girl with a body mass index of 40. Unfortunately, the effectiveness of pediatric obesity treatment is modest in younger children and declines in older children and adolescents, and few interventions involving adolescents have produced significant long-term weightloss. Nevertheless, novel strategies to alter energy balance have shown preliminary evidence of benefit in clinical trials, including a diet focused on food quality rather than fat restriction and a lifestyle approach to encourage enjoyable physical activity throughout the day rather than intermittent exercise. Parents can have an important influence on weight-related behaviors in adolescents despite typically complicated emotional dynamics at this age, especially through the use of noncoercive methods. A key parenting practice applicable to children of all ages is to create a protective environment in the home, substituting nutritious foods for un-healthful ones and facilitating physical activities instead of sedentary pursuits. Other behaviors that may promote successful long-term weight management include good sleep hygiene, stress reduction, and mindfulness. Ultimately, the obesity epidemic can be attributed to changes in the social environment that hinder healthful lifestyle habits, and prevention will require a comprehensive public health strategy. JAMA. 2012;307(5):498-508
C1 [Ludwig, David S.] Childrens Hosp Boston, Div Endocrinol, Optimal Weight Life OWL Program, Boston, MA 02115 USA.
   [Ludwig, David S.] Childrens Hosp Boston, New Balance Fdn, Obes Prevent Ctr, Boston, MA 02115 USA.
   [Ludwig, David S.] Harvard Univ, Sch Med, Boston, MA USA.
   [Ludwig, David S.] Harvard Univ, Sch Publ Hlth, Boston, MA 02115 USA.
C3 Harvard University; Harvard University Medical Affiliates; Boston
   Children's Hospital; Harvard University; Harvard University Medical
   Affiliates; Boston Children's Hospital; Harvard University; Harvard
   Medical School; Harvard University; Harvard T.H. Chan School of Public
   Health
RP Ludwig, DS (corresponding author), Childrens Hosp Boston, Div Endocrinol, Optimal Weight Life OWL Program, 300 Longwood Ave, Boston, MA 02115 USA.
EM david.ludwig@childrens.harvard.edu
OI Ludwig, David/0000-0003-3307-8544
FU National Institutes of Health; Children's Hospital Boston; National
   Institute of Diabetes and Digestive and Kidney Diseases [K24DK082730]
FX The author has completed and submitted the ICMJE Form for Disclosure of
   Potential Conflicts of Interest. Dr Ludwig reports receiving grants from
   the National Institutes of Health and foundations for obesity-related
   research, mentoring, and patient care and royalties from a book about
   childhood obesity.Dr Ludwig is supported in part by an endowment from
   Children's Hospital Boston and career award K24DK082730 from the
   National Institute of Diabetes and Digestive and Kidney Diseases.
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NR 107
TC 25
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U2 60
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 0098-7484
EI 1538-3598
J9 JAMA-J AM MED ASSOC
JI JAMA-J. Am. Med. Assoc.
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WC Medicine, General & Internal
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GA 884SH
UT WOS:000299728000031
PM 22215761
DA 2025-06-11
ER

PT J
AU Gray, K
   Bennett, M
AF Gray, Kelly
   Bennett, Martin
TI Role of DNA damage in atherosclerosis-Bystander or participant?
SO BIOCHEMICAL PHARMACOLOGY
LA English
DT Article
DE Atherosclerosis; DNA damage; Apoptosis; Senescence
ID SMOOTH-MUSCLE-CELLS; TYPE-2 DIABETES-MELLITUS; CORONARY-ARTERY-DISEASE;
   STRAND-BREAK REPAIR; OXIDATIVE STRESS; CARDIOVASCULAR-DISEASE; METABOLIC
   SYNDROME; ENDOTHELIAL DYSFUNCTION; VASCULAR-DISEASE; APOLIPOPROTEIN-E
AB Atherosclerosis leading to cardiovascular disease is the leading cause of death among western populations. Atherosclerosis in characterised by the development of a fibrofatty lesion that consists of a diverse cell population, including inflammatory cells that create an intensely oxidising environment within the vessel. Coupled with normal replication, the local intracellular and extracellular environment causes damage to cellular DNA that is recognised and repaired by the DNA damage response (DDR) pathway. The role of DNA damage and the resulting deregulation of 'normal' cellular behaviour and subsequent loss of cell cycle control checkpoints have been widely studied in cancer. However, despite the extensive evidence for DNA damage in atherosclerosis, it is only over the past two decades that a causative link between DNA damage and atherosclerosis has been hypothesised. Whilst atherosclerosis is a feature of human disease characterised by defects in DNA damage, currently the role of DNA damage in the initiation and progression of atherosclerosis remains highly debated, as a 'chicken and egg' situation. This review will analyse the evidence for, the causes of, and consequences of DNA damage in atherosclerosis, detail the DNA damage response pathway that results in these consequences, and highlight therapeutic opportunities in this area. We also outline the evidence that DNA damage is a cause of both initiation and progression of atherosclerosis, and not just a consequence of disease. (C) 2011 Elsevier Inc. All rights reserved.
C1 [Gray, Kelly; Bennett, Martin] Univ Cambridge, Div Cardiovasc Med, Addenbrookes Hosp, Addenbrookes Ctr Clin Invest, Cambridge CB2 0QQ, England.
C3 University of Cambridge; Cambridge University Hospitals NHS Foundation
   Trust; Addenbrooke's Hospital
RP Gray, K (corresponding author), Univ Cambridge, Div Cardiovasc Med, Addenbrookes Hosp, Addenbrookes Ctr Clin Invest, Box 110, Cambridge CB2 0QQ, England.
EM klg42@cam.ac.uk
OI Bennett, Martin/0000-0002-2565-1825
FU British Heart Foundation [RG/08/009/25841] Funding Source: Medline;
   Medical Research Council [G0800784, G1000847] Funding Source: Medline;
   MRC [G1000847, G0800784] Funding Source: UKRI
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NR 86
TC 48
Z9 49
U1 0
U2 11
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0006-2952
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GA 812UA
UT WOS:000294317200001
PM 21726542
OA Green Submitted, Green Accepted
DA 2025-06-11
ER

PT J
AU Melamed, S
   Shirom, A
   Toker, S
   Shapira, I
AF Melamed, Samuel
   Shirom, Arie
   Toker, Sharon
   Shapira, Itzhak
TI Burnout and risk of type 2 diabetes: A prospective study of apparently
   healthy employed persons
SO PSYCHOSOMATIC MEDICINE
LA English
DT Article
DE type 2 diabetes; stress; burnout
ID C-REACTIVE PROTEIN; INSULIN-RESISTANCE ATHEROSCLEROSIS; REPORTED MEDICAL
   HISTORY; CORONARY-HEART-DISEASE; STRESSFUL LIFE EVENTS; METABOLIC
   SYNDROME; CARDIOVASCULAR-DISEASE; DEPRESSIVE SYMPTOMATOLOGY; RECIPROCAL
   RELATIONSHIPS; MYOCARDIAL-INFARCTION
AB Objective: This prospective study was designed to test the extent to which the onset of type 2 diabetes in apparently healthy individuals was predicted by burnout, a unique affective response to combined exposure to chronic stressors. Methods: The study participants were 677 employed men and women who were followed up for 3 to 5 years (mean = 3.6 years) for the onset of diagnosed type 2 diabetes. Burnout was assessed by the Shirom-Melamed Burnout Measure with its three subscales: emotional exhaustion, physical fatigue, and cognitive weariness. Results: The burnout symptoms were remarkably consistent over the follow-up period irrespective of changes in place of work and in employment status. During the follow-up period, 17 workers developed type 2 diabetes. Logistic regression results indicated that burnout was associated with a 1.84-fold increased risk of diabetes (95% confidence interval [CI] = 1.19-2.85) even after adjusting for age, sex, body mass index, smoking, alcohol use, leisure time physical activity, initial job category, and follow-up duration. In a subsample of 507 workers, the relative risk of diabetes was found to be much higher after additional control for blood pressure levels (odds ratio = 4.32, 95% Cl = 1.75-10.67), available only for this subsample. Conclusions: These findings suggest that chronic burnout might be a risk factor for the onset of type 2 diabetes in apparently healthy individuals.
C1 Tel Aviv Univ, Sackler Fac Med, Dept Epidemiol & Prevent Med, IL-69978 Tel Aviv, Israel.
   Tel Aviv Univ, Fac Management, IL-69978 Tel Aviv, Israel.
   Tel Aviv Sourasky Med Ctr, Tel Aviv, Israel.
C3 Tel Aviv University; Sackler Faculty of Medicine; Tel Aviv University;
   Tel Aviv University; Sackler Faculty of Medicine; Tel Aviv Sourasky
   Medical Center
RP Melamed, S (corresponding author), Tel Aviv Univ, Sackler Fac Med, Dept Epidemiol & Prevent Med, IL-69978 Tel Aviv, Israel.
EM smelamed@post.tau.ac.il
RI Toker, Sharon/P-5428-2015
OI Toker, Sharon/0000-0001-7621-6607
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NR 92
TC 154
Z9 203
U1 0
U2 40
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0033-3174
EI 1534-7796
J9 PSYCHOSOM MED
JI Psychosom. Med.
PD NOV-DEC
PY 2006
VL 68
IS 6
BP 863
EP 869
DI 10.1097/01.psy.0000242860.24009.f0
PG 7
WC Psychiatry; Psychology; Psychology, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry; Psychology
GA 108SK
UT WOS:000242259300008
PM 17132837
DA 2025-06-11
ER

PT J
AU Naeini, Z
   Abaj, F
   Esmaeily, Z
   Alvandi, E
   Rafiee, M
   Koohdani, F
AF Naeini, Zeinab
   Abaj, Faezeh
   Esmaeily, Zahra
   Alvandi, Ehsan
   Rafiee, Masoumeh
   Koohdani, Fariba
TI A Nutrigenetic Approach to Investigate ApoB EcoR1 Polymorphism-Dietary
   Acid Load Interactions on Lipid and Anthropometric-Related Outcomes in
   Adults with Dyslipidemic Type 2 Diabetes
SO LIFESTYLE GENOMICS
LA English
DT Article
ID CORONARY-ARTERY-DISEASE; LOW-DENSITY-LIPOPROTEIN; CARDIOMETABOLIC
   RISK-FACTORS; APOLIPOPROTEIN-B; GENE POLYMORPHISMS; DNA POLYMORPHISMS;
   HEART-DISEASE; METABOLIC-ACIDOSIS; OXIDATIVE STRESS; ISCHEMIC-STROKE
AB Introduction: Despite multiple studies which have considered the role of dietary acid load (DAL) or Apolipoprotein B (ApoB) EcoR1 polymorphism in diabetes, none have assessed their interplay effect on metabolic markers. Therefore, this study aimed to determine the interaction of EcoR1 and DAL on metabolic markers among adults with Type 2 diabetes mellitus (T2DM).Methods: 492 randomly selected individuals with T2DM were recruited for this cross-sectional study. Dietary intake was evaluated by a validated food frequency questionnaire. DAL was assessed as net-endogenous acid production (NEAP) and potential renal acid load (PRAL). Real-time-PCR was used to genotype EcoR1. Metabolic markers were also assessed. The interaction effect of the polymorphism and DAL indexes was analyzed by analysis of covariance (ANCOVA). Result: The frequency of EcoR1 genotypes was not different between dyslipidemic and normolipidemic participants (P>0.05). Among participants with dyslipidemia, those with the GG genotype and who consumed a higher level of NEAP had higher body mass index (BMI) (p=0.03) and waist circumference (WC; p =0.02). Moreover, triglyceride (TG) concentration (P=0.007), the LDL/HDL ratio (P=0.03) and the TG/HDL (P=0.03) ratio were significantly higher in A allele carriers with higher than the median intake of NEAP, in comparison with GG homozygotes. Finally, GA/AA carriers who had a higher intake of PRAL had a higher TG concentration (P=0.006) and TG/HDL ratio (P=0.01) compared to lower median intake in the dyslipidemia group. Discussion/Conclusion: In the dyslipidemic group, there was a higher TG concentration among individuals with the GA/AA genotype and a higher intake of NEAP/ PRAL. Also, in this group, a higher intake of NEAP may be considered as a risk factor for increased levels of BMI and WC among participants with the GG genotype.
C1 [Naeini, Zeinab; Koohdani, Fariba] Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Cellular & Mol Nutr, Tehran, Iran.
   [Abaj, Faezeh; Esmaeily, Zahra] Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Community Nutr, Tehran, Iran.
   [Alvandi, Ehsan] Western Sydney Univ, Sch Med, Campbelltown, NSW, Australia.
   [Rafiee, Masoumeh] Isfahan Univ Med Sci IUMS, Sch Nutr & Food Sci, Dept Clin Nutr, Esfahan, Iran.
   [Rafiee, Masoumeh] Isfahan Univ Med Sci, Sch Nutr & Food Sci, Dept Clin Nutr, Hezar Jerib St,POB 8174673461, Esfahan, Iran.
   [Koohdani, Fariba] Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Cellular & Mol Nutr, 44,Hojat-dost Alley,Naderi St,POB 141556117, Tehran, Iran.
C3 Tehran University of Medical Sciences; Tehran University of Medical
   Sciences; Western Sydney University; University of Sydney; Isfahan
   University of Medical Sciences; Isfahan University of Medical Sciences;
   Tehran University of Medical Sciences
RP Rafiee, M (corresponding author), Isfahan Univ Med Sci, Sch Nutr & Food Sci, Dept Clin Nutr, Hezar Jerib St,POB 8174673461, Esfahan, Iran.; Koohdani, F (corresponding author), Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Cellular & Mol Nutr, 44,Hojat-dost Alley,Naderi St,POB 141556117, Tehran, Iran.
EM masomeh.rafiei@gmail.com; fkoohdan@tums.ac.ir
RI Rafiee, Masoumeh/AAC-8806-2019; Koohdani, Fariba/D-1298-2018; Abaj,
   Faezeh/ABA-8101-2021
OI Alvandi, Ehsan/0000-0001-9258-1006
FU Tehran University of Medical Sciences [15060]
FX This work was supported by the Tehran University of Medical Sciences
   (Grant number 15060, 2015).
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NR 102
TC 1
Z9 1
U1 0
U2 5
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 2504-3161
EI 2504-3188
J9 LIFESTYLE GENOM
JI Lifestyle Genom.
PY 2023
VL 16
IS 1
BP 61
EP 72
DI 10.1159/000528656
EA DEC 2022
PG 12
WC Genetics & Heredity; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Genetics & Heredity; Nutrition & Dietetics
GA DO8T1
UT WOS:000898438000001
OA gold
DA 2025-06-11
ER

PT J
AU Odriozola, A
   Santos-Laso, A
   del Barrio, M
   Cabezas, J
   Iruzubieta, P
   Arias-Loste, MT
   Rivas, C
   Duque, JCR
   Antón, A
   Fábrega, E
   Crespo, J
AF Odriozola, Aitor
   Santos-Laso, Alvaro
   del Barrio, Maria
   Cabezas, Joaquin
   Iruzubieta, Paula
   Arias-Loste, Maria Teresa
   Rivas, Coral
   Duque, Juan Carlos Rodriguez
   Anton, Angela
   Fabrega, Emilio
   Crespo, Javier
TI Fatty Liver Disease, Metabolism and Alcohol Interplay: A Comprehensive
   Review
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE non-alcoholic fatty liver disease; alcohol-related liver disease;
   cirrhosis; hepatocellular carcinoma
ID ENDOPLASMIC-RETICULUM STRESS; TUMOR-NECROSIS-FACTOR; ETHANOL-INDUCED
   DISRUPTION; GUT BARRIER DYSFUNCTION; ADIPOSE-TISSUE; RISK-FACTORS;
   NONALCOHOLIC STEATOHEPATITIS; CONFERS SUSCEPTIBILITY; HEPATOCYTE
   APOPTOSIS; MOLECULAR-MECHANISMS
AB Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease worldwide, and its incidence has been increasing in recent years because of the high prevalence of obesity and metabolic syndrome in the Western population. Alcohol-related liver disease (ArLD) is the most common cause of cirrhosis and constitutes the leading cause of cirrhosis-related deaths worldwide. Both NAFLD and ArLD constitute well-known causes of liver damage, with some similarities in their pathophysiology. For this reason, they can lead to the progression of liver disease, being responsible for a high proportion of liver-related events and liver-related deaths. Whether ArLD impacts the prognosis and progression of liver damage in patients with NAFLD is still a matter of debate. Nowadays, the synergistic deleterious effect of obesity and diabetes is clearly established in patients with ArLD and heavy alcohol consumption. However, it is still unknown whether low to moderate amounts of alcohol are good or bad for liver health. The measurement and identification of the possible synergistic deleterious effect of alcohol consumption in the assessment of patients with NAFLD is crucial for clinicians, since early intervention, advising abstinence and controlling cardiovascular risk factors would improve the prognosis of patients with both comorbidities. This article seeks to perform a comprehensive review of the pathophysiology of both disorders and measure the impact of alcohol consumption in patients with NAFLD.
C1 [Odriozola, Aitor; Santos-Laso, Alvaro; del Barrio, Maria; Cabezas, Joaquin; Iruzubieta, Paula; Arias-Loste, Maria Teresa; Rivas, Coral; Duque, Juan Carlos Rodriguez; Anton, Angela; Fabrega, Emilio; Crespo, Javier] Marques de Valdecilla Univ Hosp, Valdecilla Res Inst IDIVAL, Gastroenterol & Hepatol Dept, Clin & Translat Res Digest Dis, Av Valdecilla 25, Santander 39008, Cantabria, Spain.
C3 Hospital Universitario Marques de Valdecilla (HUMV)
RP Crespo, J (corresponding author), Marques de Valdecilla Univ Hosp, Valdecilla Res Inst IDIVAL, Gastroenterol & Hepatol Dept, Clin & Translat Res Digest Dis, Av Valdecilla 25, Santander 39008, Cantabria, Spain.
EM javier.crespo@scsalud.es
RI Rodriguez, Juan/KII-5073-2024; Aguirre-Crespo, Francisco/F-8698-2018;
   Cabezas, Joaquin/ABC-5805-2020; Fábrega, Emilio/ABG-3447-2020
OI Crespo, Javier/0000-0001-8248-0172; Arias-Loste, Maria
   Teresa/0000-0001-8864-3833; Fabrega, Emilio/0000-0003-1876-3973;
   IRUZUBIETA, PAULA/0000-0001-9476-1801; Del Barrio Azaceta,
   Maria/0000-0002-6276-7405
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NR 179
TC 14
Z9 15
U1 2
U2 12
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD APR 24
PY 2023
VL 24
IS 9
AR 7791
DI 10.3390/ijms24097791
PG 24
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA G2UE8
UT WOS:000987761800001
PM 37175497
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU John, N
   John, J
   Tarnikanti, M
   Kalpana, M
   Kamble, P
   Singhal, A
   Ganji, V
   Gaur, A
   Umesh, M
   Katta, R
   Saktivadivel, V
   Daulatabad, V
   Singaravelu, V
   Vamishidhar, I
AF John, Nitin
   John, Jyoti
   Tarnikanti, Madhuri
   Kalpana, Medala
   Kamble, Praful
   Singhal, Anish
   Ganji, Vidya
   Gaur, Archana
   Umesh, Madhusudhan
   Katta, Roja
   Saktivadivel, Varatharajan
   Daulatabad, Vandana
   Singaravelu, Vidya
   Vamishidhar, Immadi
TI Implications of lifestyle medicine in medical practice
SO JOURNAL OF FAMILY MEDICINE AND PRIMARY CARE
LA English
DT Review
DE Addiction; behavioral changes; exercise; lifestyle medicine;
   non-communicable diseases; physical activity; sexual health; sleep;
   social life; stress relaxation
ID SLEEP DURATION; HEALTH; ASSOCIATIONS; HYPERTENSION; BEHAVIORS; BENEFITS;
   QUALITY; INDIANS; ADULTS; OLDER
AB Globally, we are seeing a rise in non-communicable diseases such as obesity, hypertension, diabetes, metabolic syndrome, chronic respiratory diseases, cancer, etc., due to stressful lifestyle in this competitive world. Most of the non-communicable diseases are associated with lifestyle behavior. Presently, the role of lifestyle medicine is very critical and important in the management of chronic lifestyle-associated disorders. Considering the above facts, we decided to review the literature to gain a deeper insight into the implications of lifestyle medicine in medical practice. A literature search was conducted on PubMed, Scopus and Google Scholar databases. We observed that lifestyle medicine intervention is a growing and newer discipline and is being employed along with conventional management of non-communicable diseases by medical practitioners today, as they are strongly associated with lifestyle behaviors and practices. Motivation for change in lifestyle is challenging because it depends on the patient's determination and eagerness to adapt and accommodate to the newer lifestyle pattern. The medical practitioners should spend time in coaching patients on lifestyle-related health education. Guidance and coaching by medical practitioners will help patients adapt to practices of maintaining regular physical activity, a balanced diet, good sleep hygiene, and avoid addictions of tobacco and alcohol as part of life. Introducing real and progressive evidence-based behavioral changes to reduce the risks of lifestyle-related acute and chronic diseases in medical practice will reduce the burden of non-communicable disease.
C1 [John, Nitin; Tarnikanti, Madhuri; Kalpana, Medala; Kamble, Praful; Singhal, Anish; Ganji, Vidya; Gaur, Archana; Umesh, Madhusudhan; Katta, Roja] All India Inst Med Sci, Dept Physiol, Bibinagar, Telangana, India.
   [John, Jyoti] All India Inst Med Sci, Dept Biochem, Nagpur, Maharashtra, India.
   [Saktivadivel, Varatharajan] All India Inst Med Sci, Dept Med, Bibinagar, Telangana, India.
   [Daulatabad, Vandana] RVM Inst Med Sci, Dept Physiol, Siddipet, Telangana, India.
   [Singaravelu, Vidya] Malla Reddy Inst Med Sci, Dept Paediat, Hyderabad, Telangana, India.
   [Vamishidhar, Immadi] Govt Med Coll, Dept Physiol, Mhabubabad, Telangana, India.
   [John, Nitin] All India Inst Med Sci, Bibinagar, Telangana, India.
C3 All India Institute of Medical Sciences (AIIMS) Nagpur
RP John, N (corresponding author), All India Inst Med Sci, Bibinagar, Telangana, India.
EM drnitinjohn@yahoo.co.in
RI Katta, Roja/IUQ-5046-2023; GAUR T, ARCHANA/AAS-7311-2020; Daulatabad, Dr
   Vandana/JXO-5204-2024
OI Katta, Roja/0000-0002-2024-004X; Daulatabad, Dr
   Vandana/0000-0002-5458-9872
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NR 42
TC 2
Z9 2
U1 1
U2 5
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, Maharashtra, INDIA
SN 2249-4863
EI 2278-7135
J9 J FAM MED PRIM CARE
JI J. Fam. Med. Prim. Care
PY 2023
VL 12
IS 2
BP 208
EP 212
DI 10.4103/jfmpc.jfmpc_1587_22
PG 5
WC Primary Health Care
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA F5GI0
UT WOS:000982625500004
PM 37091003
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Goodarzi, NE
   Fatolahi, H
   Ahmadabad, SR
   Pouramir, M
   Mohammadi, S
   Khojasteh, Z
   Aghajani, M
   Azarbayjani, MA
AF Goodarzi, Niloufar Eskandari
   Fatolahi, Hoseyn
   Ahmadabad, Saleh Rahmati
   Pouramir, Mehdi
   Mohammadi, Shiva
   Khojasteh, Zohreh
   Aghajani, Mobina
   Azarbayjani, Mohammad Ali
TI The effect of arbutin and aerobic training on plasma leptin and
   adiponectin concentrations in alloxan-induced diabetic rats
SO NUTRITION CLINIQUE ET METABOLISME
LA English
DT Article
DE Metabolic syndrome; Herbal medicine; Rehabilitation exercise; Aerobic
   training
ID OXIDATIVE STRESS; ANIMAL-MODEL; WEIGHT-LOSS; SERUM; EXERCISE;
   GLIBENCLAMIDE; MARKERS; ALPHA; MEN
AB Background Leptin and adiponectin are cytokines produced excessively by adipocytes, which are relatedto metabolic disorders. This study aimed to compare the effect of aerobic training (AT) and arbutin onleptin and adiponectin in alloxan-induced diabetic rats.
   Methods. - Eighty male Wistar rats were divided into ten groups including: (1) healthy control, (2) diabeticcontrol, (3) healthy + arbutin, (4) diabetic + arbutin, (5) healthy + AT, (6) healthy + arbutin + AT, (7) diabetic + arbutin + AT, (8) diabetic + glibenclamide, (9) diabetic + AT, and (10) diabetic + glibenclamide + AT. Diabetes was induced in rats through the injection of 90 mg/kg saline-diluted alloxan. The AT was performed by swimming fosix weeks (five days a week). Arbutin was injected at 50 mg/kg, and glibenclamidewas gavaged at 0.5 mg/kg per meal.
   Results. - Improvements of leptin, glucose, adiponectin and leptin to adiponectin ratio were different( P = 0.05). Despite the significant effect of arbutin and its interaction with AT, in all cases, the effect ofglibenclamide consumption was greater compared to arbutin (P = 0.001). Interaction of AT with glibenclamide also increased this effect (P = 0.001).
   Conclusion. - Rehabilitation exercise and arbutin may offer a solution for the treatment of diabetes. However, the effect of this treatment is less than compared to glibenclamide, which may be furtherimproved through changing the dose of arbutin or AT. (c) 2022 Published by Elsevier Masson SAS on behalf of Soci ' et ' e francophone nutrition clinique etm ' etabolisme (SFNCM).
C1 [Goodarzi, Niloufar Eskandari] Islamic Azad Univ, Dept Exercise Physiol, Bushehr Sci & Res Branch, Bushehr, Iran.
   [Fatolahi, Hoseyn; Ahmadabad, Saleh Rahmati] Islamic Azad Univ, Dept Phys Educ, Pardis Branch, Pardis, Iran.
   [Pouramir, Mehdi] Babol Univ Med Sci, Cellular & Mol Biol Res Ctr, Hlth Res Inst, Babol, Iran.
   [Mohammadi, Shiva; Khojasteh, Zohreh; Azarbayjani, Mohammad Ali] Islamic Azad Univ, Dept Exercise Physiol, Cent Tehran Branch, Tehran, Iran.
   [Aghajani, Mobina] Iran Univ Med Sci, Neurousculoskeletal Res Ctr, Tehran, Iran.
C3 Islamic Azad University; Islamic Azad University; Babol University of
   Medical Sciences; Islamic Azad University; Iran University of Medical
   Sciences
RP Azarbayjani, MA (corresponding author), Islamic Azad Univ, Dept Exercise Physiol, Cent Tehran Branch, Tehran, Iran.
EM m_azarbayjani@iauctb.ac.ir
RI Azarbayjani, Mohammad Ali/AGW-7332-2022; Fatolahi, Hoseyn/AAJ-3646-2020
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NR 45
TC 0
Z9 0
U1 0
U2 3
PU MASSON EDITEUR
PI MOULINEAUX CEDEX 9
PA 21 STREET CAMILLE DESMOULINS, ISSY, 92789 MOULINEAUX CEDEX 9, FRANCE
SN 0985-0562
EI 1768-3092
J9 NUTR CLIN METAB
JI Nutr. Clin. Metab.
PD NOV
PY 2022
VL 36
IS 4
BP 285
EP 291
DI 10.1016/j.nupar.2022.09.006
EA NOV 2022
PG 7
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA D7WQ0
UT WOS:000970799000008
DA 2025-06-11
ER

PT J
AU Olechno, E
   Puscion-Jakubik, A
   Zujko, ME
AF Olechno, Ewa
   Puscion-Jakubik, Anna
   Zujko, Malgorzata Elzbieta
TI Chokeberry (A. melanocarpa (Michx.) Elliott)-A Natural Product
   for Metabolic Disorders?
SO NUTRIENTS
LA English
DT Review
DE metabolic disorders; obesity; metabolic syndrome; diabetes;
   hyperglycemia; hypertension; dyslipidemia; inflammation
ID DIPEPTIDYL PEPTIDASE IV; MELANOCARPA FRUIT JUICE; LINE-1 DNA
   METHYLATION; BLOOD-GLUCOSE LEVELS; ARONIA-MELANOCARPA; OXIDATIVE STRESS;
   BLACK CHOKEBERRY; ANTIOXIDANT CAPACITY; URIC-ACID; IN-VIVO
AB Abnormal metabolism of substances in the body can result in metabolic disorders which include obesity, cardiovascular diseases, diabetes, hypertension, chronic kidney disease, liver disease, or cancer. Foods rich in antioxidants can help to prevent and treat various types of disorders. Chokeberry fruits are rich in polyphenols, especially cyanidins, and therefore, can show a beneficial health effect. The aim of this study was to summarize and systematize reports about the effects of chokeberry on various metabolic parameters. Studies from 2000 to 2021, published in the PubMed and Google Scholar databases, were reviewed. The review of studies shows that chokeberry may have a positive effect in dyslipidemia and hypertension and may increase the body's antioxidant defense mechanisms. The anti-inflammatory effect, in turn, may translate into a reduction in the risk of metabolic disorders over a longer period of use. Changes in glucose levels were reported by studies in which the intervention lasted more than 10 weeks in patients with carbohydrate metabolism disorders. The effects of protecting the liver, inhibiting platelet aggregation, lowering uric acid levels, and having a protective effect on the kidneys require additional confirmation in human clinical trials. Consumption of chokeberry fruit did not impact on anthropometric measurements; however, it seems that chokeberry fruit can be recommended in many metabolic disorders due to the richness of bioactive ingredients.
C1 [Olechno, Ewa; Zujko, Malgorzata Elzbieta] Med Univ Bialystok, Dept Food Biotechnol, Fac Hlth Sci, Szpitalna 37 St, PL-15295 Bialystok, Poland.
   [Puscion-Jakubik, Anna] Med Univ Bialystok, Fac Pharm, Dept Bromatol, Div Lab Med, Mickiewicza 2D St, PL-15222 Bialystok, Poland.
C3 Medical University of Bialystok; Medical University of Bialystok
RP Puscion-Jakubik, A (corresponding author), Med Univ Bialystok, Fac Pharm, Dept Bromatol, Div Lab Med, Mickiewicza 2D St, PL-15222 Bialystok, Poland.
EM ewa.olechno@sd.umb.edu.pl; anna.puscion-jakubik@umb.edu.pl;
   malgorzata.zujko@umb.edu.pl
RI ; Zujko, Malgorzata Elzbieta/R-5958-2018
OI Puscion-Jakubik, Anna/0000-0002-8526-8107; Zujko, Malgorzata
   Elzbieta/0000-0002-0410-3539
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NR 211
TC 25
Z9 26
U1 3
U2 33
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JUL
PY 2022
VL 14
IS 13
AR 2688
DI 10.3390/nu14132688
PG 44
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 2V5KM
UT WOS:000823884900001
PM 35807867
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Zarezadeh, M
   Musazadeh, V
   Faghfouri, AH
   Roshanravan, N
   Dehghan, P
AF Zarezadeh, Meysam
   Musazadeh, Vali
   Faghfouri, Amir Hossein
   Roshanravan, Neda
   Dehghan, Parvin
TI Probiotics act as a potent intervention in improving lipid profile: An
   umbrella systematic review and meta-analysis
SO CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
LA English
DT Review
DE Probiotics; blood lipids; dyslipidemia; lipid profile; umbrella
   meta-analysis
ID LACTOBACILLUS-PLANTARUM KY1032; TYPE-2 DIABETES-MELLITUS; DOUBLE-BLIND;
   METABOLIC SYNDROME; OXIDATIVE STRESS; GLYCEMIC CONTROL; CURVATUS HY7601;
   SUPPLEMENTATION; CHOLESTEROL; LIPOPROTEIN
AB Several meta-analysis studies have revealed improving effects of probiotics on lipid profile, while some studies have reported controversial findings. The purpose of present study was to evaluate the efficacy of probiotics on blood lipids. Relevant studies were searched in the international databases, including PubMed, Scopus, EMBASE, Web of Science, and Cochrane Central Library up to August 2021. The pooled results were calculated with the use of a random-effects model to assess the effects of probiotics on blood lipids. Overall, 38 meta-analyses were inclueded in the study. The results indicated that the probiotics supplementation was effective on reduction of total cholesterol (TC) (ES= -0.46 mg/dL; 95% CI: -0.61, -0.30, p < 0.001; I-2= 83.8%, p < 0.001), triglycerides (TG) (ES= -0.13 mg/dl; 95% CI: -0.23, -0.04, p = 0.006; I-2= 74.7%, p < 0.001), and low-density lipoprotein cholesterol (LDL-C)levels (ES= -0.29 mg/dL; 95% CI: -0.40, -0.19, p < 0.001; I-2= 77.8%, p < 0.001). There was no significant effect of probiotics on high-density lipoprotein cholesterol (HDL-C) levels (ES= 0.02 mg/dl; 95% CI: -0.04, 0.08, p = 0.519; I-2= 72.5%, p= <0.001). The results of present umbrella meta-analysis strongly support supplementation with probiotics as an influential intervention for improving lipid profile.
C1 [Zarezadeh, Meysam; Musazadeh, Vali; Faghfouri, Amir Hossein] Tabriz Univ Med Sci, Student Res Comm, Tabriz, Iran.
   [Zarezadeh, Meysam; Dehghan, Parvin] Tabriz Univ Med Sci, Fac Nutr & Food Sci, Nutr Res Ctr, Tabriz, Iran.
   [Musazadeh, Vali; Faghfouri, Amir Hossein] Tabriz Univ Med Sci, Sch Nutr & Food Sci, Dept Community Nutr, Tabriz, Iran.
   [Roshanravan, Neda] Tabriz Univ Med Sci, Cardiovasc Res Ctr, Tabriz, Iran.
C3 Tabriz University of Medical Science; Tabriz University of Medical
   Science; Tabriz University of Medical Science; Tabriz University of
   Medical Science
RP Dehghan, P (corresponding author), Tabriz Univ Med Sci, Fac Nutr & Food Sci, Nutr Res Ctr, Tabriz, Iran.
EM dehghan.nut@gmail.com
RI Faghfouri, Amir Hossein/GLT-8484-2022; Zarezadeh, Meysam/AFJ-1712-2022;
   Dehghan, Parvin/G-3885-2015
OI Zarezadeh, Meysam/0000-0002-4268-4178; musazadeh,
   vali/0000-0002-4978-9474; Faghfouri, Amir Hossein/0000-0003-0356-7267;
   Dehghan, Parvin/0000-0001-8929-3302
FU Student Research Committee, Tabriz University of Medical Sciences
   [68323]
FX The research protocol was approved and Supported by Student Research
   Committee, Tabriz University of Medical Sciences (Registration code:
   68323).
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NR 85
TC 36
Z9 36
U1 3
U2 34
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1040-8398
EI 1549-7852
J9 CRIT REV FOOD SCI
JI Crit. Rev. Food Sci. Nutr.
PD DEC 8
PY 2022
VL 63
IS 2
BP 145
EP 158
DI 10.1080/10408398.2021.2004578
EA NOV 2021
PG 14
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA 6V0ZU
UT WOS:000722036700001
PM 34817299
DA 2025-06-11
ER

PT J
AU Gerges, SH
   Wahdan, SA
   Elsherbiny, DA
   El-Demerdash, E
AF Gerges, Samar H.
   Wahdan, Sara A.
   Elsherbiny, Doaa A.
   El-Demerdash, Ebtehal
TI Non-alcoholic fatty liver disease: An overview of risk factors,
   pathophysiological mechanisms, diagnostic procedures, and therapeutic
   interventions
SO LIFE SCIENCES
LA English
DT Review
DE Non-alcoholic steatohepatitis; Insulin resistance; Adipose tissue;
   Steatosis; Fibrosis; Diagnosis; Management
ID HEPATIC STELLATE CELLS; NF-KAPPA-B; GREEN TEA EXTRACT; URSODEOXYCHOLIC
   ACID THERAPY; ENDOPLASMIC-RETICULUM STRESS; DE-NOVO LIPOGENESIS;
   INSULIN-RESISTANCE; ZINGIBER-OFFICINALE; METABOLIC SYNDROME; ADVANCED
   FIBROSIS
AB Non-alcoholic fatty liver disease (NAFLD) is a disorder of excessive fat accumulation in the liver, known as steatosis, without alcohol overconsumption. NAFLD can either manifest as simple steatosis or steatohepatitis, known as non-alcoholic steatohepatitis (NASH), which is accompanied by inflammation and possibly fibrosis. Furthermore, NASH might progress to hepatocellular carcinoma. NAFLD and NASH prevalence is in a continuous state of growth, and by 2018, NAFLD became a devastating metabolic disease with a global pandemic prevalence. The pathophysiology of NAFLD and NASH is not fully elucidated, but is known to involve the complex interplay between different metabolic, environmental, and genetic factors. In addition, unhealthy dietary habits and pre-existing metabolic disturbances together with other risk factors predispose NAFLD development and progression from simple steatosis to steatohepatitis, and eventually to fibrosis. Despite their growing worldwide prevalence, to date, there is no FDA-approved treatment for NAFLD and NASH. Several off-label medications are used to target disease risk factors such as obesity and insulin resistance, and some medications are used for their hepatopmtective effects. Unfortunately, currently used medications are not sufficiently effective, and research is ongoing to investigate the beneficial effects of different drugs and phytochemicals in NASH. In this review article, we outline the different risk factors and pathophysiological mechanisms involved in NAFLD, diagnostic procedures, and currently used management techniques.
C1 [Gerges, Samar H.; Wahdan, Sara A.; Elsherbiny, Doaa A.; El-Demerdash, Ebtehal] Ain Shams Univ, Fac Pharm, Dept Pharmacol & Toxicol, Org African Unity St, Cairo 11566, Egypt.
C3 Egyptian Knowledge Bank (EKB); Ain Shams University
RP El-Demerdash, E (corresponding author), Ain Shams Univ, Fac Pharm, Dept Pharmacol & Toxicol, Org African Unity St, Cairo 11566, Egypt.
EM ebtehal_dm@yahoo.com
RI El-Demerdash, Ebtehal/ABE-6729-2020
OI Nesr (Gerges), Samar/0000-0003-0450-0056
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NR 276
TC 41
Z9 46
U1 0
U2 24
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0024-3205
EI 1879-0631
J9 LIFE SCI
JI Life Sci.
PD APR 15
PY 2021
VL 271
AR 119220
DI 10.1016/j.lfs.2021.119220
EA FEB 2021
PG 17
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA QT5AN
UT WOS:000626600400039
PM 33592199
DA 2025-06-11
ER

PT J
AU Elakovic, I
   Kovacevic, S
   Milutinovic, DV
   Nikolic-Kokic, A
   Glban, AM
   Spasic, M
   Tappy, L
   Djordjevic, A
   Matic, G
   Brkljacic, J
AF Elakovic, Ivana
   Kovacevic, Sanja
   Vojnovic Milutinovic, Danijela
   Nikolic-Kokic, Aleksandra
   Glban, Alhadi M.
   Spasic, Mihajlo
   Tappy, Luc
   Djordjevic, Ana
   Matic, Gordana
   Brkljacic, Jelena
TI Fructose Consumption Affects Glucocorticoid Signaling in the Liver of
   Young Female Rats
SO NUTRIENTS
LA English
DT Article
DE glucocorticoid receptor; inflammation; antioxidant enzymes; lipin-1;
   lipogenesis; fructose-fed rat
ID VISCERAL ADIPOSE-TISSUE; SUGAR-SWEETENED BEVERAGES; METABOLIC SYNDROME;
   OXIDATIVE STRESS; PHOSPHATIDATE PHOSPHOHYDROLASE; RECEPTOR FUNCTION;
   LIPID-METABOLISM; CYCLIC-AMP; EXPRESSION; INSULIN
AB The effects of early-life fructose consumption on hepatic signaling pathways and their relation to the development of metabolic disorders in later life are not fully understood. To investigate whether fructose overconsumption at a young age induces alterations in glucocorticoid signaling that might contribute to development of metabolic disturbances, we analysed glucocorticoid receptor hormone-binding parameters and expression of its target genes involved in gluconeogenesis (phosphoenolpyruvate carboxykinase and glucose-6-phosphatase) and lipid metabolism (lipin-1), as well as redox and inflammatory status in the liver of female rats subjected to a fructose-rich diet immediately after weaning. The fructose diet increased hepatic corticosterone concentration, 11 beta-hydroxysteroid dehydrogenase type 1 level, glucocorticoid receptor protein level and hormone-binding activity, as well as lipin-1 level. The expression of glucose-6-phosphatase was reduced in fructose-fed rats, while phosphoenolpyruvate carboxykinase remained unaltered. The fructose-rich diet increased the level of fructose transporter GLUT2, while the expression of fructolytic enzymes fructokinase and aldolase B remained unaltered. The diet also affected pro-inflammatory pathways, but had no effect on the antioxidant defence system. In conclusion, a fructose-rich diet applied immediately after weaning promoted lipogenesis and enhanced hepatic glucocorticoid signaling, possibly to protect against inflammatory damage, but without an effect on gluconeogenesis and antioxidant enzymes. Yet, prolonged treatment might ultimately lead to more pronounced metabolic disturbances.
C1 [Elakovic, Ivana; Kovacevic, Sanja; Vojnovic Milutinovic, Danijela; Glban, Alhadi M.; Djordjevic, Ana; Matic, Gordana; Brkljacic, Jelena] Univ Belgrade, Inst Biol Res Sinisa Stankovic, Natl Inst Republ Serbia, Dept Biochem, 142 Despot Stefan Blvd, Belgrade 11060, Serbia.
   [Nikolic-Kokic, Aleksandra; Spasic, Mihajlo] Univ Belgrade, Inst Biol Res Sinisa Stankovic, Natl Inst Republ Serbia, Dept Physiol, 142 Despot Stefan Blvd, Belgrade 11060, Serbia.
   [Tappy, Luc] Univ Lausanne, Dept Physiol, UNIL CHUV, Rue Bugnon 7, CH-1005 Lausanne, Switzerland.
C3 University of Belgrade; University of Belgrade; University of Lausanne;
   Centre Hospitalier Universitaire Vaudois (CHUV)
RP Brkljacic, J (corresponding author), Univ Belgrade, Inst Biol Res Sinisa Stankovic, Natl Inst Republ Serbia, Dept Biochem, 142 Despot Stefan Blvd, Belgrade 11060, Serbia.
EM ivana.elakovic@gmail.com; sanja.kovacevic@ibiss.bg.ac.rs;
   dvojnovic@ibiss.bg.ac.rs; san@ibiss.bg.ac.rs; hadimj2000@yahoo.com;
   spasa@ibiss.bg.ac.rs; fructose1957@gmail.com;
   djordjevica@ibiss.bg.ac.rs; gormatic@ibiss.bg.ac.rs;
   brkljacic@ibiss.bg.ac.rs
RI Kovacevic, Sanja/JZC-6964-2024; Brkljacic, Jelena/JQW-4422-2023;
   Vojnović Milutinović, Danijela/AAX-8926-2021; Tappy, Luc/A-8911-2017;
   Djordjevic, Ana/E-7840-2016; Matic, Gordana/N-7134-2014; Nikolic-Kokic,
   Aleksandra/AAD-5591-2022
OI Djordjevic, Ana/0000-0002-7042-1631; Matic, Gordana/0000-0002-0142-1056;
   Nikolic-Kokic, Aleksandra/0000-0002-1116-2035; Kovacevic,
   Sanja/0000-0002-9854-1934; Brkljacic, Jelena/0000-0003-1978-8646;
   Vojnovic Milutinovic, Danijela/0000-0002-2584-5048
FU Ministry of Education, Science, and Technological Development of the
   Republic of Serbia [451-03-68/2020-14/200007]
FX This work was funded by the Ministry of Education, Science, and
   Technological Development of the Republic of Serbia, Grant number
   451-03-68/2020-14/200007.
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NR 63
TC 4
Z9 5
U1 0
U2 5
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD NOV
PY 2020
VL 12
IS 11
AR 3470
DI 10.3390/nu12113470
PG 16
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA OX7ZV
UT WOS:000593779000001
PM 33198224
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Chen, J
   Jiang, YH
   Shi, H
   Peng, YG
   Fan, XY
   Li, CH
AF Chen, Ji
   Jiang, Yunhui
   Shi, Hua
   Peng, Yougong
   Fan, Xueying
   Li, Chenghua
TI The molecular mechanisms of copper metabolism and its roles in human
   diseases
SO PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
LA English
DT Article
DE Copper; Metabolism; Homeostasis; Chaperon; Transporter
ID EXTRACELLULAR-SUPEROXIDE DISMUTASE; TRANSGENIC MOUSE MODEL; TOXIC MILK
   MOUSE; P-TYPE ATPASES; WILSONS-DISEASE; MENKES DISEASE;
   ALZHEIMERS-DISEASE; CELLULAR COPPER; ENDOTHELIAL DYSFUNCTION; NEONATAL
   DIAGNOSIS
AB Copper is an essential element in cells; it can act as either a recipient or a donor of electrons, participating in various reactions. However, an excess of copper ions in cells is detrimental as these copper ions can generate free radicals and increase oxidative stress. In multicellular organisms, copper metabolism involves uptake, distribution, sequestration, and excretion, at both the cellular and systemic levels. Mammalian enterocytes take in bioavailable copper ions from the diet in a Ctr1-dependent manner. After incorporation, cuprous ions are delivered to ATP7A, which pumps Cu+ from enterocytes into the blood. Copper ions arrive at the liver through the portal vein and are incorporated into hepatocytes by Ctr1. Then, Cu+ can be secreted into the bile or the blood via the Atox1/ATP7B/ceruloplasmin route. In the bloodstream, this micronutrient can reach peripheral tissues and is again incorporated by Ctr1. In peripheral tissue cells, cuprous ions are either sequestrated by molecules such as metallothioneins or targeted to utilization pathways by chaperons such as Atox1, Cox17, and CCS. Copper metabolism must be tightly controlled in order to achieve homeostasis and avoid disorders. A hereditary or acquired copper unbalance, including deficiency, overload, or misdistribution, may cause or aggravate certain diseases such as Menkes disease, Wilson disease, neurodegenerative diseases, anemia, metabolic syndrome, cardiovascular diseases, and cancer. A full understanding of copper metabolism and its roles in diseases underlies the identification of novel effective therapies for such diseases.
C1 [Chen, Ji; Fan, Xueying; Li, Chenghua] Sichuan Univ, Coll Life Sci, Minist Educ, Ctr Growth Metab & Aging,Key Lab Biol Resources &, Chengdu 610065, Peoples R China.
   [Chen, Ji] Seventh Peoples Hosp Chengdu, Dept Med Oncol, Chengdu 610041, Peoples R China.
   [Jiang, Yunhui] Second Peoples Hosp Jingmen, Pathol Dept, Jingmen 448000, Peoples R China.
   [Shi, Hua] Sichuan Univ, West China Univ Hosp 2, Dept Lab Med, Chengdu 610041, Peoples R China.
   [Peng, Yougong] Second Peoples Hosp Jingmen, Dept Gen Surg, Jingmen 448000, Peoples R China.
C3 Ministry of Education - China; Sichuan University; Sichuan University
RP Chen, J (corresponding author), Sichuan Univ, Coll Life Sci, Minist Educ, Ctr Growth Metab & Aging,Key Lab Biol Resources &, Chengdu 610065, Peoples R China.; Chen, J (corresponding author), Seventh Peoples Hosp Chengdu, Dept Med Oncol, Chengdu 610041, Peoples R China.
EM lichenghua@scu.edu.cn
FU National Natural Science Foundation of China [91749121]; Outstanding
   Young and Middle-aged Scientific and Technological Innovation Team
   Program of Colleges and Universities in Hubei Province [T201819];
   Fundamental Research Funds for the Central Universities [SCU2019D013]
FX This work was supported by National Natural Science Foundation of China
   (91749121 to Li), the Outstanding Young and Middle-aged Scientific and
   Technological Innovation Team Program of Colleges and Universities in
   Hubei Province (T201819 to Jiang), and the Fundamental Research Funds
   for the Central Universities (SCU2019D013).
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NR 167
TC 286
Z9 319
U1 29
U2 155
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0031-6768
EI 1432-2013
J9 PFLUG ARCH EUR J PHY
JI Pflugers Arch.
PD OCT
PY 2020
VL 472
IS 10
BP 1415
EP 1429
DI 10.1007/s00424-020-02412-2
EA JUN 2020
PG 15
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA NK5AS
UT WOS:000538351800001
PM 32506322
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Monti, CB
   Codari, M
   De Cecco, CN
   Secchi, F
   Sardanelli, F
   Stillman, AE
AF Monti, Caterina B.
   Codari, Marina
   De Cecco, Carlo Nicola
   Secchi, Francesco
   Sardanelli, Francesco
   Stillman, Arthur E.
TI Novel imaging biomarkers: epicardial adipose tissue evaluation
SO BRITISH JOURNAL OF RADIOLOGY
LA English
DT Review
ID CORONARY-ARTERY-DISEASE; COMPUTED-TOMOGRAPHY; ATRIAL-FIBRILLATION;
   PERICARDIAL FAT; VOLUME; CT; ASSOCIATION; CALCIUM; HEART; INFLAMMATION
AB Epicardial adipose tissue (EAT) is a metabolically activated beige adipose tissue, non-homogeneously surrounding the myocardium. Physiologically, EAT regulates toxic fatty acids, protects the coronary arteries against mechanical strain, regulates proinflammatory cytokines, stimulates the production of nitric oxide, reduces oxidative stress, and works as a thermogenic source against hypothermia. Conversely, EAT has pathologic paracrine interactions with the surrounded vessels, and might favour the onset of atrial fibrillation. In addition, initial atherosclerotic lesions can promote inflammation and trigger the EAT production of cytokines increasing vascular inflammation, which, in turn, may help the development of collateral vessels but also of self-stimulating, dysregulated inflammatory process, increasing coronary artery disease severity. Variations in EAT were also linked to metabolic syndrome, Echocardiography first estimated EAT measuring its thickness on the free wall of the right ventricle but does not allow accurate volumetric EAT estimates. Cardiac CT (CCT) and cardiac MR (CMR) allow for three-dimensional EAT estimates, the former showing higher spatial resolution and reproducibility but being limited by radiation exposure and long segmentation times, the latter being radiation-free but limited by lower spatial resolution and reproducibility, higher cost, and difficulties for obese patients. EAT radiodensity at CCT could to be related to underlying metabolic processes. The correlation between EAT and response to certain pharmacological therapies has also been investigated, showing promising results. In the future, semi-automatic or fully automatic techniques, machine/deep-learning methods, if validated, will facilitate research for various EAT measures and may find a place in CCT/CMR reporting.
C1 [Monti, Caterina B.; Secchi, Francesco; Sardanelli, Francesco] Univ Milan, Dept Biomed Sci Hlth, Milan, Italy.
   [Codari, Marina] Politecn Milan, Dipartimento Elettron Informaz & Bioingn, Milan, Italy.
   [De Cecco, Carlo Nicola; Stillman, Arthur E.] Emory Univ Hosp, Dept Radiol & Imaging Sci, Div Cardiothorac Imaging, 1364 Clifton Rd NE, Atlanta, GA 30322 USA.
   [Secchi, Francesco; Sardanelli, Francesco] IRCCS Policlin San Donato, Dept Radiol, Milan, Italy.
C3 University of Milan; Polytechnic University of Milan; Emory University;
   IRCCS Policlinico San Donato
RP De Cecco, CN (corresponding author), Emory Univ Hosp, Dept Radiol & Imaging Sci, Div Cardiothorac Imaging, 1364 Clifton Rd NE, Atlanta, GA 30322 USA.
EM carlo.dececco@emory.edu
RI Sardanelli, Francesco/M-2917-2016; Codari, Marina/H-1595-2016; De Cecco,
   Carlo N./C-8572-2017; Monti, Caterina Beatrice/AAD-7754-2019; Secchi,
   Francesco/J-7088-2016
OI Codari, Marina/0000-0001-8475-2071; De Cecco, Carlo
   N./0000-0002-2956-3101; Monti, Caterina Beatrice/0000-0002-9539-8642;
   Secchi, Francesco/0000-0002-0357-1808
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NR 74
TC 53
Z9 56
U1 0
U2 15
PU BRITISH INST RADIOLOGY
PI LONDON
PA 48-50 ST JOHN ST, LONDON, ENGLAND
SN 0007-1285
EI 1748-880X
J9 BRIT J RADIOL
JI Br. J. Radiol.
PY 2020
VL 93
IS 1113
AR 20190770
DI 10.1259/bjr.20190770
PG 8
WC Radiology, Nuclear Medicine & Medical Imaging
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Radiology, Nuclear Medicine & Medical Imaging
GA NC8UK
UT WOS:000561487500007
PM 31782934
OA Green Published
DA 2025-06-11
ER

PT J
AU Huang, JP
   Hsu, SC
   Li, DE
   Chen, KH
   Kuo, CY
   Hung, LM
AF Huang, Jiung-Pang
   Hsu, Sheng-Chieh
   Li, Dai-Er
   Chen, Kuan-Hsing
   Kuo, Chao-Yu
   Hung, Li-Man
TI Resveratrol Mitigates High-Fat Diet-Induced Vascular Dysfunction by
   Activating the Akt/eNOS/NO and Sirt1/ER Pathway
SO JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
LA English
DT Article
DE resveratrol; high-fat diet; vascular dysfunction; Akt/eNOS/NO pathway;
   Sirt1/ER pathway
ID ENDOTHELIAL CELL-INTERACTIONS; ESTROGEN-RECEPTOR-ALPHA; NITRIC-OXIDE;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; PROLIFERATION; ADHESION;
   DISEASES; STRESS; HEALTH
AB We investigated whether resveratrol (RSV) can attenuate obesity and diabetes progression and improve diabetes-induced vascular dysfunction, and we attempted to delineate its underlying mechanisms. Male C57Bl/6 mice were administered a high-fat diet (HFD) for 17 weeks. Mice developed type 2 diabetes with increased body weight, hyperglycemia, hyperinsulinemia, and hyperlipidemia. Oral gavage with RSV significantly reversed the symptoms induced by the HFD. Insulin sensitivity likewise improved after the RSV intervention in these mice. Phenylephrine-induced cremaster arteriolar constriction was impaired, whereas RSV treatment significantly mitigated the vessel responsiveness to phenylephrine. The obese diabetic mice exhibited increased leukocyte rolling, adhesion, and transmigration in the postcapillary venules of the cremaster muscle. By contrast, RSV treatment significantly attenuated HFD-induced extravasation. RSV significantly recovered phosphorylated Akt and eNOS expression in the thoracic aorta. In addition, activated adenosine monophosphate-activated protein kinase in the thoracic aorta was involved in the improvement of epithelial function after RSV intervention. RSV considerably upregulated the plasma NO level in HFD mice. Moreover, RSV-enhanced human umbilical vein endothelial cells healing through Sirt1/ER pathway may be involved in the prevention of leukocyte extravasation. Collectively, RSV attenuates diabetes-induced vascular dysfunction by activating Akt/eNOS/NO and Sirt1/ER pathway. Our mechanistic study provides a potential RSV-based therapeutic strategy against cardiovascular disease.
C1 [Huang, Jiung-Pang; Hsu, Sheng-Chieh; Li, Dai-Er; Kuo, Chao-Yu; Hung, Li-Man] Chang Gung Univ, Dept & Grad Inst Biomed Sci, Coll Med, Taoyuan, Taiwan.
   [Huang, Jiung-Pang; Hung, Li-Man] Chang Gung Univ, Hlth Aging Res Ctr, Taoyuan, Taiwan.
   [Hsu, Sheng-Chieh] Chang Gung Mem Hosp, Dept Obstet & Gynecol, Linkou, Taiwan.
   [Chen, Kuan-Hsing; Hung, Li-Man] Chang Gung Mem Hosp, Kidney Res Ctr, Linkou, Taiwan.
C3 Chang Gung University; Chang Gung University; Chang Gung Memorial
   Hospital; Chang Gung Memorial Hospital
RP Hung, LM (corresponding author), Chang Gung Univ, Dept Biomed Sci, Coll Med, 259 Wenhua 1st Rd, Taoyuan 33302, Taiwan.
EM lisahung@mail.cgu.edu.tw
FU Chang Gung Memorial Hospital [CMRPD1F0531, CMRPD1A0203, CMRPD1C0463];
   Chang Gung University [EMRPD1D0881]; Ministry of Science and Technology
   of Taiwan [MOST 104-2320-B-182-001, MOST 104-2320-B-182-015]
FX Supported by research grants from Chang Gung Memorial Hospital
   (CMRPD1F0531, CMRPD1A0203, and CMRPD1C0463), Chang Gung University
   (EMRPD1D0881), and the Ministry of Science and Technology (MOST
   104-2320-B-182-001 and MOST 104-2320-B-182-015) of Taiwan to L.-M. Hung.
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NR 50
TC 27
Z9 28
U1 0
U2 9
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0160-2446
EI 1533-4023
J9 J CARDIOVASC PHARM
JI J. Cardiovasc. Pharmacol.
PD NOV
PY 2018
VL 72
IS 5
BP 231
EP 241
DI 10.1097/FJC.0000000000000621
PG 11
WC Cardiac & Cardiovascular Systems; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Pharmacology & Pharmacy
GA HK3TS
UT WOS:000457841700004
PM 30399060
DA 2025-06-11
ER

PT J
AU Chung, E
   Kim, Y
   Usen, O
AF Chung, Eunhee
   Kim, Youngdeok
   Usen, Oduware
TI Associations Between Parity, Obesity, and Cardiovascular Risk Factors
   Among Middle-Aged Women
SO JOURNAL OF WOMENS HEALTH
LA English
DT Article
ID C-REACTIVE PROTEIN; CORONARY-HEART-DISEASE; BLOOD-PRESSURE; PREGNANCY
   COMPLICATIONS; POSTMENOPAUSAL WOMEN; METABOLIC SYNDROME; US ADULTS;
   HEALTH; HYPERTENSION; STRESS
AB Background: Several studies have demonstrated an association between parity and the risk of developing cardiovascular disease (CVD) in middle-aged women; however, some inconsistencies still remain in the literature after accounting for obesity. The purpose of this study was to examine the association between parity and the risk factors of CVD while accounting for current obesity status in middle-aged women.
   Method: Data for this study came from the National Health and Nutrition Examination Survey 2007-2012. The final analytic sample included 2024 middle-aged women (40-60 years old). General linear models predicting CVD risk factors based on parity (nulliparous, 1, 2, 3, and >= 4) were established after controlling for study covariates. Least square adjusted means of CVD risk factors and associated 95% confidence intervals were estimated across parity and body mass index (BMI) levels.
   Results: Women with >= 4 parity (8.34%; standard error [SE] = 0.84) showed significantly distinct demographic characteristics and health conditions, including obesity (49.08%; SE = 3.55). There were no significant associations between parity and CVD risk factors after controlling for covariates. Follow-up analyses showed consistent results across parity; however, CVD risk factors were significantly increased with higher BMI levels, regardless of parity status.
   Conclusions: Our results suggest that parity is not a significant predictor of CVD risk factors in middle-aged women, whereas current overweight or obesity status is more important when explaining the risk of the development of CVD.
C1 [Chung, Eunhee; Kim, Youngdeok; Usen, Oduware] Texas Tech Univ, Dept Kinesiol & Sport Management, Mail Box 43011, Lubbock, TX 79409 USA.
C3 Texas Tech University System; Texas Tech University
RP Chung, E (corresponding author), Texas Tech Univ, Dept Kinesiol & Sport Management, Mail Box 43011, Lubbock, TX 79409 USA.
EM eunhee.chung@ttu.edu
RI Chung, Eunhee/AAX-6863-2020
OI Chung, Eunhee/0000-0002-4501-9333
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NR 52
TC 7
Z9 7
U1 0
U2 11
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-9996
EI 1931-843X
J9 J WOMENS HEALTH
JI J. Womens Health
PD AUG
PY 2016
VL 25
IS 8
BP 818
EP 825
DI 10.1089/jwh.2015.5581
PG 8
WC Public, Environmental & Occupational Health; Medicine, General &
   Internal; Obstetrics & Gynecology; Women's Studies
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; General & Internal
   Medicine; Obstetrics & Gynecology; Women's Studies
GA DS5GE
UT WOS:000380808600009
PM 26886718
DA 2025-06-11
ER

PT J
AU Jeong, YY
   Ryu, JH
   Shin, JH
   Kang, MJ
   Kang, JR
   Han, J
   Kang, D
AF Jeong, Yi Yeong
   Ryu, Ji Hyeon
   Shin, Jung-Hye
   Kang, Min Jung
   Kang, Jae Ran
   Han, Jaehee
   Kang, Dawon
TI Comparison of Anti-Oxidant and Anti-Inflammatory Effects between Fresh
   and Aged Black Garlic Extracts
SO MOLECULES
LA English
DT Article
DE anti-inflammatory agents; antioxidants; garlic; NF-kappa B; sugar
ID RAW 264.7 MACROPHAGES; KAPPA-B; METABOLIC SYNDROME; OXIDATIVE STRESS;
   TISSUE-INJURY; INFLAMMATION; FRUCTOSE; ALLICIN; GLUCOSE; ACTIVATION
AB Numerous studies have demonstrated that aged black garlic (ABG) has strong anti-oxidant activity. Little is known however regarding the anti-inflammatory activity of ABG. This study was performed to identify and compare the anti-oxidant and anti-inflammatory effects of ABG extract (ABGE) with those of fresh raw garlic (FRG) extract (FRGE). In addition, we investigated which components are responsible for the observed effects. Hydrogen peroxide (H2O2) and lipopolysaccharide (LPS) were used as a pro-oxidant and pro-inflammatory stressor, respectively. ABGE showed high ABTS and DPPH radical scavenging activities and low ROS generation in RAW264.7 cells compared with FRGE. However, inhibition of cyclooxygenase-2 and 5-lipooxygenase activities by FRGE was stronger than that by ABGE. FRGE reduced PGE(2), NO, IL-6, IL-1 beta, LTD4, and LTE4 production in LPS-activated RAW264.7 cells more than did ABGE. The combination of FRGE and sugar (galactose, glucose, fructose, or sucrose), which is more abundant in ABGE than in FRGE, decreased the anti-inflammatory activity compared with FRGE. FRGE-induced inhibition of NF-kappa B activation and pro-inflammatory gene expression was blocked by combination with sugars. The lower anti-inflammatory activity in ABGE than FRGE could result from the presence of sugars. Our results suggest that ABGE might be helpful for the treatment of diseases mediated predominantly by ROS.
C1 [Jeong, Yi Yeong] Gyeongsang Natl Univ, Dept Allergy, Jinju 660751, South Korea.
   [Jeong, Yi Yeong] Gyeongsang Natl Univ, Dept Resp Med, Jinju 660751, South Korea.
   [Jeong, Yi Yeong] Gyeongsang Natl Univ Hosp, Jinju 660751, South Korea.
   [Ryu, Ji Hyeon; Han, Jaehee; Kang, Dawon] Gyeongsang Natl Univ, Dept Physiol, Coll Med, Jinju 660751, South Korea.
   [Shin, Jung-Hye; Kang, Min Jung; Kang, Jae Ran] Namhae Garl Res Inst, Dept Res & Dev, Namhae 668812, South Korea.
   [Han, Jaehee; Kang, Dawon] Gyeongsang Natl Univ, Inst Hlth Sci, Jinju 660751, South Korea.
C3 Gyeongsang National University; Gyeongsang National University;
   Gyeongsang National University; Gyeongsang National University Hospital;
   Gyeongsang National University; Gyeongsang National University
RP Kang, D (corresponding author), Gyeongsang Natl Univ, Dept Physiol, Coll Med, Jinju 660751, South Korea.; Kang, D (corresponding author), Gyeongsang Natl Univ, Inst Hlth Sci, Jinju 660751, South Korea.
EM dr202202@naver.com; wlgus9217@naver.com; whanbee@hanmail.net;
   jung-75@hanmail.net; rani921@hanmail.net; jheehan@gnu.ac.kr;
   dawon@gnu.ac.kr
RI Ryu, Ji/AAU-2771-2020
OI Jung Hye, Shin/0000-0002-1505-1965
FU National Research Foundation of Korea - Korean government (Ministry of
   Education, Science and Technology) [NRF-2015R1D1A3A01017856,
   NRF-2015R1A5A2008833]; Gyeongsang National University Hospital
   [GNUHBRIF-2013-0007]; Korean government (Ministry of Science, ICT and
   Future Planning)
FX This work was supported by grants from the National Research Foundation
   of Korea (NRF-2015R1D1A3A01017856 and NRF-2015R1A5A2008833), which is
   funded by the Korean government (Ministry of Education, Science and
   Technology and Ministry of Science, ICT and Future Planning), and by
   biomedical research institute fund (GNUHBRIF-2013-0007) from the
   Gyeongsang National University Hospital (to Yi-Yeong Jung).
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NR 50
TC 93
Z9 103
U1 2
U2 67
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1420-3049
J9 MOLECULES
JI Molecules
PD APR
PY 2016
VL 21
IS 4
AR 430
DI 10.3390/molecules21040430
PG 15
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA DK8CO
UT WOS:000375155000043
PM 27043510
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Sheedfar, F
   Di Biase, S
   Koonen, D
   Vinciguerra, M
AF Sheedfar, Fareeba
   Di Biase, Stefano
   Koonen, Debby
   Vinciguerra, Manlio
TI Liver diseases and aging: friends or foes?
SO AGING CELL
LA English
DT Review
DE aging; cytokines; demography; injury; insulin; IGF-1 signalling;
   reactive oxygen species; mouse models; NAFLD; NASH
ID FATTY LIVER; INSULIN-RESISTANCE; HEPATOCELLULAR-CARCINOMA; RAT-LIVER;
   METABOLIC SYNDROME; IN-VIVO; AGE; SENESCENCE; CIRRHOSIS; HEALTHY
AB The liver is the only internal human organ capable of natural regeneration of lost tissue, as little as 25% of a liver can regenerate into a whole liver. The process of aging predisposes to hepatic functional and structural impairment and metabolic risk. Therefore, understanding how aging could affect the molecular pathology of liver diseases is particularly important, and few studies to date have tackled this complex process. The most common liver disease, affecting one-third of the overall population, is nonalcoholic fatty liver disease (NAFLD), characterized by an intrahepatic accumulation of lipids. NAFLD can evolve into nonalcoholic steatohepatitis (NASH) in the presence of oxidative stress and inflammation. NASH is a serious risk factor for disabling and deadly liver diseases such as cirrhosis and hepatocellular carcinoma (HCC). Old age seems to favor NAFLD, NASH, and ultimately HCC, in agreement with the inflamm-aging theory, according to which aging accrues inflammation. However, the incidence of HCC drops significantly in the very elderly (individuals aged more than 70) and the relationship between the progression of NAFLD/NASH/HCC and very old age is obscure. In this review, we discuss the literature and we argue that there might be an age window in which the liver becomes resistant to the development of injury; this needs to be studied to understand fully the interaction between age and liver diseases from a therapeutic perspective.
C1 [Sheedfar, Fareeba; Koonen, Debby] Univ Groningen, Univ Med Ctr Groningen, NL-9713 AV Groningen, Netherlands.
   [Di Biase, Stefano] Univ So Calif, Andrus Gerontol Ctr, Los Angeles, CA USA.
   [Vinciguerra, Manlio] UCL, Inst Liver & Digest Hlth, Div Med, London NW3 2PF, England.
   [Vinciguerra, Manlio] Euromediterranean Inst Sci & Technol IEMEST, Palermo, Italy.
   [Vinciguerra, Manlio] IRCCS Casa Sollievo Sofferenza, Dept Med Sci, Div Internal Med, San Giovanni Rotondo, Italy.
C3 University of Groningen; University of Southern California; University
   of London; University College London; IRCCS Casa Sollievo Della
   Sofferenza
RP Vinciguerra, M (corresponding author), UCL, Inst Liver & Digest Hlth, Div Med, Royal Free Campus,Rowland Hill St, London NW3 2PF, England.
EM m.vinciguerra@ucl.ac.uk
RI Vinciguerra, Manlio/N-1309-2015
OI , Fareeba/0000-0002-1315-1903; Vinciguerra, Manlio/0000-0002-1768-3894;
   Koonen, Debby/0000-0002-1881-8826
FU Graduate School for Drug Exploration (GUIDE), University of Groningen;
   CTMM, the Center for Translational Molecular Medicine; project PREDICCt
   [01C-104]; Dutch Heart Foundation; Dutch Diabetes Research Foundation;
   Dutch Kidney Foundation; Italian Ministry of Health [GR-2010-2311017];
   Associazione Italiana per la Ricerca sul Cancro, Italy
FX F.S. is supported by the Graduate School for Drug Exploration (GUIDE),
   University of Groningen. D. K. is supported within the framework of
   CTMM, the Center for Translational Molecular Medicine
   (http://www.ctmm.nl), project PREDICCt (grant 01C-104), and supported by
   the Dutch Heart Foundation, Dutch Diabetes Research Foundation and Dutch
   Kidney Foundation. M. V. is supported by the Italian Ministry of Health,
   GR-2010-2311017, and is a recipient of a My First AIRC Grant (MFAG) from
   Associazione Italiana per la Ricerca sul Cancro, Italy.
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NR 78
TC 187
Z9 203
U1 2
U2 47
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1474-9726
J9 AGING CELL
JI Aging Cell
PD DEC
PY 2013
VL 12
IS 6
BP 950
EP 954
DI 10.1111/acel.12128
PG 5
WC Cell Biology; Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Geriatrics & Gerontology
GA 255AN
UT WOS:000327211700002
PM 23815295
OA hybrid, Green Submitted
DA 2025-06-11
ER

PT J
AU Shi, ZM
   Zhang, CL
   Zhou, MH
   Zhen, SQ
   Taylor, AW
AF Shi, Zumin
   Zhang, Cuilin
   Zhou, Minghao
   Zhen, Shiqi
   Taylor, Anne W.
TI Exposure to the Chinese famine in early life and the risk of anaemia in
   adulthood
SO BMC PUBLIC HEALTH
LA English
DT Article
DE Chinese famine; Anemia; Adults; Fetal exposure
ID LONG-TERM HEALTH; IRON-DEFICIENCY; METABOLIC SYNDROME; MATERNAL STRESS;
   GREAT LEAP; CONSEQUENCES; ASSOCIATION; OVERWEIGHT; CHILDREN; JIANGSU
AB Background: Famine exposure during the early stage of life is related to a number of adulthood diseases. The objective of this study was to examine the association of early life exposure to the famine in China (1959-1961) with the risk of anaemia in adulthood.
   Methods: We used the data of 2007 adults born between 1954 and 1964 in Jiangsu province from the 2002 Chinese National Nutrition and Health Survey. Anaemia was defined as haemoglobin concentration <12 g/dl in women and <13 g/dl in men.
   Results: Prevalence of anaemia in adulthood in nonexposed, fetal-exposed, early-childhood, mid-childhood, and late-childhood exposed to famine groups were 26.0%, 33.8%, 28.1%, 28.2% and 29.7%, respectively. Overall, fetal-exposed to famine was associated with 37% increased risk of anaemia as compared with those non-exposed after adjusting for income, education, place of residence, smoking, alcohol drinking, job, hypertension and BMI; relative risk (95% confidence interval) (RR (95% CI)) was 1.37 (1.09, 1.71). In general, this association appeared to be stronger among men, those who were currently overweight or obese, or those of lower educational levels. Corresponding RR (95% CI) was 1.87 (1.21-2.87), 1.75 (1.20-2.56), and 2.07 (1.37-3.12), respectively.
   Conclusions: Fetal exposure to the Chinese famine was associated with an increased risk of anaemia in adulthood.
C1 [Shi, Zumin; Zhen, Shiqi] Jiangsu Prov Ctr Dis Control & Prevent, Dept Nutr & Foodborne Dis Prevent, Nanjing, Jiangsu, Peoples R China.
   [Shi, Zumin; Taylor, Anne W.] Univ Adelaide, Discipline Med, Adelaide, SA 5000, Australia.
   [Zhang, Cuilin] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Epidemiol Branch, Div Epidemiol Stat & Prevent Res, Bethesda, MD 20852 USA.
   [Zhou, Minghao] Jiangsu Prov Ctr Dis Control & Prevent, Nanjing 210009, Jiangsu, Peoples R China.
C3 Jiangsu Provincial Center for Disease Control & Prevention; University
   of Adelaide; National Institutes of Health (NIH) - USA; NIH Eunice
   Kennedy Shriver National Institute of Child Health & Human Development
   (NICHD); Jiangsu Provincial Center for Disease Control & Prevention
RP Shi, ZM (corresponding author), Jiangsu Prov Ctr Dis Control & Prevent, Dept Nutr & Foodborne Dis Prevent, Nanjing, Jiangsu, Peoples R China.
EM zumin.shi@adelaide.edu.au
RI zhou, minghao/GZA-7244-2022; zhang, cl/JDW-6549-2023; Shi,
   Zumin/A-1093-2009; Taylor, Anne/F-5708-2010
OI Zhang, Cuilin/0000-0002-8014-2708; Shi, Zumin/0000-0002-3099-3299;
   Taylor, Anne/0000-0002-4422-7974
FU Jiangsu Provincial Natural Science Foundation [BK2008464]; Jiangsu
   Provincial Health Bureau, China; Intramural Research Program of the
   Eunice Kennedy Shriver National Institute of Child Health & Human
   Development, National Institutes of Health
FX The study is supported by Jiangsu Provincial Natural Science Foundation
   (BK2008464) and the Jiangsu Provincial Health Bureau, China.Dr. Cuilin
   Zhang were supported by the Intramural Research Program of the Eunice
   Kennedy Shriver National Institute of Child Health & Human Development,
   National Institutes of Health.
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NR 33
TC 20
Z9 24
U1 0
U2 18
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2458
J9 BMC PUBLIC HEALTH
JI BMC Public Health
PD OCT 1
PY 2013
VL 13
AR 904
DI 10.1186/1471-2458-13-904
PG 7
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA 227RJ
UT WOS:000325131100001
PM 24079608
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Murtaugh, MA
   Sweeney, C
   Ma, KN
   Potter, JD
   Caan, BJ
   Wolff, RK
   Slattery, ML
AF Murtaugh, Maureen A.
   Sweeney, Carol
   Ma, Khe-Ni
   Potter, John D.
   Caan, Bette J.
   Wolff, Roger K.
   Slattery, Martha L.
TI Vitamin D receptor gene polymorphisms, dietary promotion of insulin
   resistance, and colon and rectal cancer
SO NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
LA English
DT Article
ID CONJUGATED LINOLEIC-ACID; WHOLE-GRAIN INTAKE; MEAT CONSUMPTION PATTERNS;
   COLORECTAL-CANCER; METABOLIC SYNDROME; GROWTH-INHIBITION;
   DAIRY-PRODUCTS; GLYCEMIC INDEX; VDR GENOTYPE; D ANALOGS
AB Modifiable risk factors in colorectal cancer etiology and their interactions with genetic susceptibility are of particular interest. Functional vitamin D receptor (VDR) gene polymorphisms may influence carcinogenesis through modification of cell growth, protection from oxidative stress, cell-cell matrix effects, or insulin and insulin-like growth factor pathways. We investigated interactions between foods (dairy products, red and processed meat, and whole and refined grains) and dietary patterns (sucrose-to-fiber ratio and glycemic index) associated with insulin resistance with the FokI polymorphism of the FDR gene and colon and rectal cancer risk. Data (diet, anthropometrics, and lifestyle) and DNA came from case-control studies of colon (1, 698 cases and 1, 861 controls) and rectal cancer (752 cases and 960 controls) in northern California, Utah, and the Twin Cities metropolitan area, Minnesota (colon cancer study only). Unconditional logistic regression models were adjusted for smoking, race, sex, age, body mass index, physical activity, energy intake, dietary fiber, and calcium. The lowest colon cancer risk was observed with the Ff/ffFokI genotypes and a low sucrose-to-fiber ratio. Rectal cancer risk decreased with greater consumption of dairy products and increased with red or processed meat consumption and the FF genotype. Modifiable dietary risk factors may be differentially important among individuals by VDR genotype and may act through the insulin pathway to affect colon cancer risk and through fat, calcium, or other means to influence rectal cancer risk.
C1 Univ Utah, Hlth Res Ctr, Dept Family & Prevent Med, Salt Lake City, UT 84108 USA.
   Fred Hutchinson Canc Res Ctr, Seattle, WA 98109 USA.
   Kaiser Permanente, Div Res, Oakland, CA 94611 USA.
C3 Utah System of Higher Education; University of Utah; Fred Hutchinson
   Cancer Center; Kaiser Permanente
RP Murtaugh, MA (corresponding author), Univ Utah, Hlth Res Ctr, Dept Family & Prevent Med, 375 Chipeta Way,Suite A, Salt Lake City, UT 84108 USA.
EM maureen.murtaugh@hsc.utah.edu
RI Murtaugh, Maureen/AAN-6225-2020; Potter, John/JEO-4316-2023
OI Murtaugh, Maureen/0000-0001-5281-0302; Caan, Bette/0000-0002-5803-310X;
   Sweeney, Carol/0000-0003-1113-7160; Potter, John/0000-0001-5439-1500
FU NCI NIH HHS [CA48998, N01-PC-67000, R01 CA048998, R01 CA085846, CA85846]
   Funding Source: Medline
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NR 60
TC 40
Z9 45
U1 0
U2 5
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 0163-5581
EI 1532-7914
J9 NUTR CANCER
JI Nutr. Cancer
PY 2006
VL 55
IS 1
BP 35
EP 43
DI 10.1207/s15327914nc5501_5
PG 9
WC Oncology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Nutrition & Dietetics
GA 086GO
UT WOS:000240662000005
PM 16965239
DA 2025-06-11
ER

PT J
AU Wang, JX
   Liu, XZ
   Guo, Z
   Zhang, HL
   Qi, L
   Liu, J
   Liu, P
   Xie, GX
   Wang, XN
AF Wang, Jia-Xuan
   Liu, Xin-Zhu
   Guo, Zhen
   Zhang, Hui-Lin
   Qi, Li
   Liu, Jia
   Liu, Ping
   Xie, Guo-Xiang
   Wang, Xiao-Ning
TI Differences in Fatty Acid Metabolism between MCDD and HFD Induced
   Metabolic Dysfunction-associated Fatty Liver Disease Model Mice
SO BIOLOGICAL PROCEDURES ONLINE
LA English
DT Article
DE Metabolic dysfunction-associated Fatty Liver Disease; Animal Model;
   Methionine-choline-deficient Diet; High-fat Diet; Fatty Acid Metabolism
ID HEPATIC LIPID-ACCUMULATION; NONALCOHOLIC STEATOHEPATITIS; OXIDATION;
   NAFLD; LIPOTOXICITY; RESISTANCE; STEATOSIS; STRESS
AB BackgroundThe global incidence of metabolic dysfunction-associated fatty liver disease (MAFLD) is increasing annually, which has become a major public-health concern. MAFLD is typically associated with obesity, hyperlipemia, or metabolic syndrome. Dietary induction is one of the most common methods for preparing animal models of MAFLD. However, there are phenotypic differences between methionine-choline-deficient diet (MCDD) and high fat diet (HFD) models.MethodsTo explore the differences in hepatic fatty acid metabolism between MCDD and HFD induced MAFLD, we analyzed serum and liver tissue from the two MAFLD models.ResultsWe found that liver fat accumulation and liver function damage were common pathological features in both MAFLD models. Furthermore, in the MCDD model, the expression of hepatic fatty acid transport proteins increased, while the expression of hepatic fatty acid efflux proteins and mRNA decreased, along with a decrease in blood lipid levels. In the HFD model, the expression of hepatic fatty acid uptake proteins, efflux proteins and efflux mRNA increased, along with an increase in blood lipid levels.ConclusionImpaired fatty acid oxidation and increased hepatic fatty acid uptake play key roles in the pathogenesis of the two MAFLD models. The inverse changes in de novo lipogenesis and fatty acid efflux may represent an important pathological mechanism that leads to the phenotypic differences between the MCDD and HFD models.
C1 [Wang, Jia-Xuan; Guo, Zhen; Zhang, Hui-Lin; Qi, Li; Liu, Jia; Liu, Ping; Wang, Xiao-Ning] Shanghai Univ Tradit Chinese Med, Inst Interdisciplinary Sci, Shanghai 201203, Peoples R China.
   [Wang, Jia-Xuan] Shanghai Univ Tradit Chinese Med, Yueyang Hosp Integrated Tradit Chinese & Western M, Dept Hepatol, Shanghai 200437, Peoples R China.
   [Liu, Xin-Zhu; Liu, Ping; Wang, Xiao-Ning] Shanghai Univ Tradit Chinese Med, Shuguang Hosp, Inst Liver Dis, Shanghai 201203, Peoples R China.
   [Liu, Xin-Zhu] Shanghai Univ Tradit Chinese Med, Shanghai Municipal Hosp Tradit Chinese Med, Shanghai 200071, Peoples R China.
   [Guo, Zhen] Southwest Med Univ, Affiliated Tradit Chinese Med Hosp, Luzhou 646000, Sichuan, Peoples R China.
   [Xie, Guo-Xiang] Human Metabol Inst Inc, Shenzhen 518109, Guangdong, Peoples R China.
   [Xie, Guo-Xiang] Kunming Univ Sci & Technol, Fac Food Sci & Engn, Kunming 650500, Peoples R China.
C3 Shanghai University of Traditional Chinese Medicine; Shanghai University
   of Traditional Chinese Medicine; Shanghai University of Traditional
   Chinese Medicine; Shanghai University of Traditional Chinese Medicine;
   Southwest Medical University; Kunming University of Science & Technology
RP Liu, P; Wang, XN (corresponding author), Shanghai Univ Tradit Chinese Med, Inst Interdisciplinary Sci, Shanghai 201203, Peoples R China.; Liu, P; Wang, XN (corresponding author), Shanghai Univ Tradit Chinese Med, Shuguang Hosp, Inst Liver Dis, Shanghai 201203, Peoples R China.; Xie, GX (corresponding author), Human Metabol Inst Inc, Shenzhen 518109, Guangdong, Peoples R China.; Xie, GX (corresponding author), Kunming Univ Sci & Technol, Fac Food Sci & Engn, Kunming 650500, Peoples R China.
EM liuliver@vip.sina.com; xieguoxiang@hmibiotech.com; wxntcm@126.com
FU National Natural Science Foundation of China [81774196]; Natural Science
   Foundation of Shanghai Municipality of China [22ZR1459200]
FX This research was funded by the National Natural Science Foundation of
   China (81774196) and the Natural Science Foundation of Shanghai
   Municipality of China (22ZR1459200).
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NR 52
TC 0
Z9 0
U1 1
U2 1
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1480-9222
J9 BIOL PROCED ONLINE
JI Biol. Proced. Online
PD APR 14
PY 2025
VL 27
IS 1
AR 14
DI 10.1186/s12575-025-00276-3
PG 11
WC Biochemical Research Methods
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 1JK7Z
UT WOS:001466454700001
PM 40229695
DA 2025-06-11
ER

PT J
AU Uriburu, FMC
   Zampini, IC
   Maldonado, LM
   Mattson, MG
   Salvatori, D
   Isla, MI
AF Uriburu, Florencia Maria Correa
   Zampini, Iris Catiana
   Maldonado, Luis Maria
   Mattson, Milagros Gomez
   Salvatori, Daniela
   Isla, Maria Ines
TI Chemical Characterization and Biological Activities of a Beverage of
   Zuccagnia punctata, an Endemic Plant of Argentina with Blueberry
   Juice and Lemon Honey
SO PLANTS-BASEL
LA English
DT Article
DE Zuccagnia punctata; Vaccinium
   corymbosum; functional beverages; powder
ID STRUCTURALLY-RELATED FLAVONOIDS; ANTIOXIDANT ACTIVITY; METABOLIC
   SYNDROME; VASCULAR DYSFUNCTION; OXIDATIVE STRESS; MEDICINAL-PLANT;
   EXTRACTS; CAV.; MICROENCAPSULATION; BLACKBERRY
AB In this study, the production of functional beverages of Zuccagnia punctata Cav. (jarilla), a native medicinal plant from Argentina, and Vaccinium corymbosum (blueberry), with lemon honey as a sweetener, is described. The beverage was formulated by using jarilla extract and blueberry juice with maltodextrin as an encapsulant material. The beverage was dried by both spray-drying and freeze-drying. Both beverages showed high water solubility with adequate features for handling, transport, and storage. The chromatic parameters indicate tones of mauve. Both the total polyphenol and flavonoid contents were retained after being spray-dried (92 and 100%, respectively). The anthocyanins were less stable under spray-dried conditions (58% retained). Both beverages showed high scavenger capacity on ABTS center dot+, HO center dot, and H2O2 (SC50 between 3.56 and 36.90 mu g GAE/mL) and exhibited in vitro inhibitor potential of alpha-glucosidase, alpha-amylase, and lipase activities (IC50 of between 2.97 and 27.19 mu g GAE/mL). The powdered beverage obtained by spray-drying presented the greatest preference in sensory tests. The beverages were neither toxic nor mutagenic in the concentration range with biological activity. During short-term storage, both beverages showed stability. The results obtained would support the use of a powdered beverage made from an Argentinean native plant and blueberries as a functional food.
C1 [Uriburu, Florencia Maria Correa; Zampini, Iris Catiana; Isla, Maria Ines] Univ Nacl Tucuman UNT, Inst Bioprospecc & Fisiol Vegetal INBIOFIV, CONICET, San Martin 1545, RA-T4000CBG San Miguel De Tucuman, Argentina.
   [Uriburu, Florencia Maria Correa; Maldonado, Luis Maria] Famailla INTA, Inst Nacl Tecnol Agr, Estn Expt Agr, Ruta Prov 301-km 32, RA-4132 Famailla, Argentina.
   [Zampini, Iris Catiana; Isla, Maria Ines] Univ Nacl Tucuman, Fac Ciencias Nat, Miguel Lillo 205, RA-T4000JFE San Miguel De Tucuman, Argentina.
   [Isla, Maria Ines] Univ Nacl Tucuman, Inst Miguel Lillo UNT, Miguel Lillo 205, RA-T4000JFE San Miguel De Tucuman, Argentina.
   [Mattson, Milagros Gomez; Salvatori, Daniela] Inst Invest & Desarrollo Ingn Proc Biotecnol & Ene, RA-8300 Neuquen, Argentina.
C3 Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET);
   Instituto Nacional de Tecnologia Agropecuaria (INTA); Universidad
   Nacional de Tucuman; Universidad Nacional de Tucuman
RP Isla, MI (corresponding author), Univ Nacl Tucuman UNT, Inst Bioprospecc & Fisiol Vegetal INBIOFIV, CONICET, San Martin 1545, RA-T4000CBG San Miguel De Tucuman, Argentina.; Isla, MI (corresponding author), Univ Nacl Tucuman, Fac Ciencias Nat, Miguel Lillo 205, RA-T4000JFE San Miguel De Tucuman, Argentina.; Isla, MI (corresponding author), Univ Nacl Tucuman, Inst Miguel Lillo UNT, Miguel Lillo 205, RA-T4000JFE San Miguel De Tucuman, Argentina.
EM florcorreau@gmail.com; zampini@csnat.unt.edu.ar;
   lmaldo@correo.inta.gov.ar; milagros.gomez@probien.gob.ar;
   dmsalvatori@hotmail.com; misla@csnat.unt.edu.ar
OI Salvatori, Daniela Marisol/0000-0002-2090-5371; Correa Uriburu,
   Florencia Maria/0000-0001-7233-9861; Zampini, Iris
   Catiana/0000-0001-7941-1678; Isla, Maria Ines/0000-0002-4261-4284
FU Universidad Nacional de Tucuman [PIUNT 2018-G637]; Agencia Nacional de
   Promocion Cientifica y Tecnica (ANPCyT) [PICT 2017-4416, PICT2019-2658,
   PICT 2020-3619, PICT-2021-CAT-II-00132]; Consejo Nacional de
   Investigaciones Cientificas y Tecnicas (CONICET-PUE) [2018-0011];
   Williams Foundation; Sustainable use of Ibero-American vegetable biomass
   resources in cosmetics" (CYTED) [P320RT0186]
FX This research was funded by the Universidad Nacional de Tucuman (PIUNT
   2018-G637 Project), Agencia Nacional de Promocion Cientifica y Tecnica
   (ANPCyT PICT 2017-4416; PICT2019-2658; PICT 2020-3619;
   PICT-2021-CAT-II-00132), Consejo Nacional de Investigaciones Cientificas
   y Tecnicas (CONICET-PUE 2018-0011),Williams Foundation 2023,
   Complementary funds for research projects with impact in Argentine
   territory and the Biolates network "P320RT0186-Sustainable use of
   Ibero-American vegetable biomass resources in cosmetics" (CYTED).
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NR 63
TC 3
Z9 3
U1 3
U2 3
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
SN 2223-7747
J9 PLANTS-BASEL
JI Plants-Basel
PD NOV
PY 2024
VL 13
IS 22
AR 3143
DI 10.3390/plants13223143
PG 19
WC Plant Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences
GA N7F5P
UT WOS:001365952500001
PM 39599352
OA gold
DA 2025-06-11
ER

PT J
AU Miyao, M
   Kawai, C
   Kotani, H
   Minami, H
   Abiru, H
   Hamayasu, H
   Eguchi, S
   Tamaki, K
AF Miyao, Masashi
   Kawai, Chihiro
   Kotani, Hirokazu
   Minami, Hirozo
   Abiru, Hitoshi
   Hamayasu, Hideki
   Eguchi, Satoru
   Tamaki, Keiji
TI Mitochondrial fission in hepatocytes as a potential therapeutic target
   for nonalcoholic steatohepatitis
SO HEPATOLOGY RESEARCH
LA English
DT Article
DE autophagy; metabolic syndrome; mitochondrial dynamics; mitochondrial
   dysfunction; obesity
ID FATTY LIVER-DISEASE; FUSION; DYNAMICS; CYCLE; DRP1
AB Aim The mitochondria are highly plastic and dynamic organelles; mitochondrial dysfunction has been reported to play causative roles in diabetes, cardiovascular diseases, and nonalcoholic fatty liver disease (NAFLD). However, the relationship between mitochondrial fission and NAFLD pathogenesis remains unknown. We aimed to investigate whether alterations in mitochondrial fission could play a role in the progression of NAFLD. Methods Mice were fed a standard diet or choline-deficient, L-amino acid-defined (CDAA) diet with vehicle or mitochondrial division inhibitor-1. Results Substantial enhancement of mitochondrial fission in hepatocytes was triggered by 4 weeks of feeding and was associated with changes reflecting the early stage of human nonalcoholic steatohepatitis (NASH), steatotic change with liver inflammation, and hepatocyte ballooning. Excessive mitochondrial fission inhibition in hepatocytes and lipid metabolism dysregulation in adipose tissue attenuated liver inflammation and fibrogenesis but not steatosis and the systemic pathological changes in the early and chronic fibrotic NASH stages (4- and 12-week CDAA feeding). These beneficial changes due to the suppression of mitochondrial fission against the liver and systemic injuries were associated with decreased autophagic responses and endoplasmic reticulum stress in hepatocytes. Injuries to other liver cells, such as endothelial cells, Kupffer cells, and hepatic stellate cells, were also attenuated by the inhibition of mitochondrial fission in hepatocytes. Conclusions Taken together, these findings suggest that excessive mitochondrial fission in hepatocytes could play a causative role in NAFLD progression by liver inflammation and fibrogenesis through altered cell cross-talk. This study provides a potential therapeutic target for NAFLD.
C1 [Miyao, Masashi; Kawai, Chihiro; Minami, Hirozo; Abiru, Hitoshi; Hamayasu, Hideki; Tamaki, Keiji] Kyoto Univ, Grad Sch Med, Dept Forens Med, Kyoto, Japan.
   [Kotani, Hirokazu] Mie Univ, Grad Sch Med, Dept Forens Med & Sci, Tsu, Mie, Japan.
   [Eguchi, Satoru] Temple Univ, Lewis Katz Sch Med, Cardiovasc Res Ctr, Philadelphia, PA 19122 USA.
C3 Kyoto University; Mie University; Pennsylvania Commonwealth System of
   Higher Education (PCSHE); Temple University
RP Miyao, M (corresponding author), Kyoto Univ, Grad Sch Med, Dept Forens Med, Sakyo Ku, Yoshida Konoe Cho, Kyoto 6068501, Japan.
EM miyaom@fp.med.kyoto-u.ac.jp
FU Japan Society for the Promotion of Science [20K10555, 21K17324];
   Fujiwara Memorial Foundation; Grants-in-Aid for Scientific Research
   [21K17324, 20K10555] Funding Source: KAKEN
FX Japan Society for the Promotion of Science, Grant/Award Numbers:
   20K10555, 21K17324; Fujiwara Memorial Foundation, Grant/Award Number:
   Research Grant
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NR 40
TC 8
Z9 8
U1 3
U2 11
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1386-6346
EI 1872-034X
J9 HEPATOL RES
JI Hepatol. Res.
PD DEC
PY 2022
VL 52
IS 12
BP 1020
EP 1033
DI 10.1111/hepr.13832
EA SEP 2022
PG 14
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 8H0NW
UT WOS:000849862400001
PM 36001355
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Nutmakul, T
AF Nutmakul, Thanutchaporn
TI A review on benefits of quercetin in hyperuricemia and gouty arthritis
SO SAUDI PHARMACEUTICAL JOURNAL
LA English
DT Review
DE Quercetin; Hyperuricemia; Gout; NLRP3 inflammasome; Antioxidant
ID URIC-ACID LEVELS; NLRP3 INFLAMMASOME ACTIVATION; XANTHINE-OXIDASE
   ACTIVITIES; METABOLIC SYNDROME; BLOOD-PRESSURE; CARDIOVASCULAR-DISEASE;
   OXIDATIVE STRESS; INHIBITION; RUTIN; RISK
AB Hyperuricemia becomes a public health problem worldwide. It is not only a major risk factor for gout but also associated with the development of life-threatening diseases such as chronic kidney disease and car-diovascular diseases. Although there are several available therapeutic drugs, some serious adverse effects and contraindications are concerned. These drive the search for an alternative therapy that is effective and safe. Quercetin is of particular interesting since it has been reported numerous pharmacological activities, especially anti-hyperuricemia, antioxidant, anti-inflammation and amelioration of metabolic syndromes and cardiovascular diseases which are comorbidities of hyperuricemia and gout. In addition, quercetin has been widely used as a health supplement for many diseases however, the use for hyper-uricemia and gout has not been indicated. Therefore, this review aims to gather and summarize published data regarding the efficacy in preclinical and clinical studies along with possible mechanism of action, and safety aspect of quercetin in order to support the use of quercetin as a dietary supplement for pre-vention and management of hyperuricemia and gouty arthritis and/or use as alternative or combination therapy to minimize the side effects of the conventional drugs.(c) 2022 The Author(s). Published by Elsevier B.V. on behalf of King Saud University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
C1 [Nutmakul, Thanutchaporn] Mahidol Univ, Ramathibodi Hosp, Grad Program Nutr, Fac Med, Bangkok 10400, Thailand.
C3 Mahidol University
RP Nutmakul, T (corresponding author), Mahidol Univ, Ramathibodi Hosp, Grad Program Nutr, Fac Med, Bangkok 10400, Thailand.
EM thanutchaporn.nut@mahidol.ac.th
OI Nutmakul, Thanutchaporn/0000-0002-1896-978X
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NR 85
TC 38
Z9 42
U1 15
U2 75
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1319-0164
EI 2213-7475
J9 SAUDI PHARM J
JI Saudi Pharm. J.
PD JUL
PY 2022
VL 30
IS 7
BP 918
EP 926
DI 10.1016/j.jsps.2022.04.013
EA JUL 2022
PG 9
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 3M2ZB
UT WOS:000835328400003
PM 35903522
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Feng, LN
   Chen, YP
   Xu, K
   Li, YC
   Riaz, F
   Lu, KK
   Chen, Q
   Du, XJ
   Wu, LT
   Cao, D
   Li, CY
   Lu, SM
   Li, DM
AF Feng, Lina
   Chen, Yanping
   Xu, Ke
   Li, Yingchao
   Riaz, Farooq
   Lu, Kaikai
   Chen, Qian
   Du, Xiaojuan
   Wu, Litao
   Cao, Dan
   Li, Chunyan
   Lu, Shemin
   Li, Dongmin
TI Cholesterol-induced leucine aminopeptidase 3 (LAP3) upregulation
   inhibits cell autophagy in pathogenesis of NAFLD
SO AGING-US
LA English
DT Article
DE NAFLD; autophagy; LAP3; cholesterol; biomarker
ID INDUCED METABOLIC SYNDROME; HIGH-FAT; NONALCOHOLIC STEATOHEPATITIS;
   MALIGNANT DEVELOPMENT; DIET; CONTRIBUTES; EXPRESSION; MANAGEMENT; STRESS
AB Objectives: Leucine aminopeptidase 3 (LAP3), an M1 member of leucine aminopeptidase, was reported to be significantly upregulated in serum of nonalcoholic fatty liver disease (NAFLD) patients. However, the underlying mechanisms of LAP3 in NAFLD pathogenesis are still unknown. We aim to investigate the role of LAP3 in NAFLD pathogenesis and explore whether LAP3 has the potential to be a candidate biomarker in serum for NAFLD diagnosis.
   Methods: Liver tissues and serum from NASH rats, serum from patients with NAFLD were obtained to evaluate the LAP3 expression. Detection of GSSG/GSH, intracellular reactive oxygen species (ROS), and LC3 expression by elevation/ reduction of LAP3 expression to determine the role of LAP3 in NAFLD pathogenesis. Finally, the correlation analysis was conducted to evaluate the association between LAP3 expression and clinical indexes of NAFLD.
   Results: LAP3 expression was upregulated in hepatocytes and serum in E3 rats with NASH after 6-month HFD feeding. Cholesterol (CHO) dramatically upregulated LAP3 in LO2 cells, and then lead to negative regulation of autophagy. Moreover, LAP3 levels were also significantly increased in NAFLD patients compared to healthy controls. Correlation analysis revealed that serum LAP3 levels were positively correlated with TG, gamma-glutamyltranspeptidase (GGT), and fasting blood glucose levels, while there was a negative correlation with HDL levels.
   Conclusions: The cholesterol-dependent upregulation of LAP3 in hepatocytes plays a critical role in the pathogenesis of NAFLD via inhibiting autophagy. Moreover, LAP3 could serve as a potential novel candidate biomarker for the diagnosis of NAFLD.
C1 [Feng, Lina; Riaz, Farooq; Lu, Kaikai; Chen, Qian; Du, Xiaojuan; Wu, Litao; Lu, Shemin; Li, Dongmin] Xi An Jiao Tong Univ, Sch Basic Med Sci, Hlth Sci Ctr, Dept Biochem & Mol Biol, Xian 710061, Shaanxi, Peoples R China.
   [Feng, Lina; Riaz, Farooq; Lu, Kaikai; Chen, Qian; Du, Xiaojuan; Wu, Litao; Lu, Shemin; Li, Dongmin] Xi An Jiao Tong Univ, Key Lab Environm & Genes Related Dis, Minist Educ China, Xian 710061, Shaanxi, Peoples R China.
   [Chen, Yanping; Li, Chunyan] Yanan Univ, Affiliated Hosp, Dept Infect Dis, Yanan, Peoples R China.
   [Chen, Yanping; Cao, Dan] Yanan Second Peoples Hosp, Dept Infect Dis, Yanan, Peoples R China.
   [Xu, Ke] Xi An Jiao Tong Univ, Xian Hong Hui Hosp, Dept Joint Surg, Hlth Sci Ctr, Xian, Peoples R China.
   [Li, Yingchao] Xi An Jiao Tong Univ, Affiliated Hosp 1, Dept Gastroenterol, Xian 710061, Peoples R China.
C3 Xi'an Jiaotong University; Xi'an Jiaotong University; Ministry of
   Education - China; Yanan University; Xi'an Jiaotong University; Xi'an
   Jiaotong University
RP Li, DM (corresponding author), Xi An Jiao Tong Univ, Sch Basic Med Sci, Hlth Sci Ctr, Dept Biochem & Mol Biol, Xian 710061, Shaanxi, Peoples R China.; Li, DM (corresponding author), Xi An Jiao Tong Univ, Key Lab Environm & Genes Related Dis, Minist Educ China, Xian 710061, Shaanxi, Peoples R China.
EM lidongm@mail.xjtu.edu.cn
RI Li, Dongmin/KIJ-1251-2024; xu, ke/JSL-2305-2023; Du,
   Xiaojuan/IWU-3128-2023; Li, Chunyan/HJI-6957-2023; Lu,
   Shemin/M-3350-2018; Riaz, Farooq/AAN-1092-2020; Riaz, Farooq/O-9330-2017
OI Riaz, Farooq/0000-0001-9944-8881
FU National Natural Science Foundation of China [82070892, 81770864,
   81370952]; Natural Science Basic Research Project of Shaanxi Province
   [2013K21-22-03]; Fundamental Research Funds for the Central Universities
   [zrzd2017007]
FX This work was supported by grants from the National Natural Science
   Foundation of China [No. 82070892, 81770864 and 81370952]; the Natural
   Science Basic Research Project of Shaanxi Province [No. 2013K21-22-03]
   and the Fundamental Research Funds for the Central Universities [grant
   number zrzd2017007].
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NR 41
TC 15
Z9 17
U1 3
U2 28
PU IMPACT JOURNALS LLC
PI ORCHARD PARK
PA 6666 E QUAKER ST, STE 1, ORCHARD PARK, NY 14127 USA
SN 1945-4589
J9 AGING-US
JI Aging-US
PD APR 15
PY 2022
VL 14
IS 7
BP 3259
EP 3275
PG 17
WC Cell Biology; Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Geriatrics & Gerontology
GA 0W5UV
UT WOS:000789092300021
PM 35404840
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Zubrzycki, A
   Cierpka-Kmiec, K
   Kmiec, Z
   Wronska, A
AF Zubrzycki, A.
   Cierpka-Kmiec, K.
   Kmiec, Z.
   Wronska, A.
TI THE ROLE OF LOW-CALORIE DIETS AND INTERMITTENT FASTING IN THE TREATMENT
   OF OBESITY AND TYPE-2 DIABETES
SO JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
LA English
DT Review
DE obesity; type-2 diabetes; low-calorie diet; intermittent fasting;
   insulin sensitivity; oxidative stress; metabolic syndrome;
   cardiovascular disease
ID INDUCED-WEIGHT-LOSS; LIFE-STYLE INTERVENTION; SUBCUTANEOUS
   ADIPOSE-TISSUE; DAILY ENERGY RESTRICTION; ALTERNATE-DAY; INSULIN
   SENSITIVITY; PHYSICAL-ACTIVITY; DISEASE RISK; LOSS PROGRAM;
   METABOLICALLY HEALTHY
AB Obesity is a condition associated with an increased risk of metabolic disorders, and in particular of type-2 diabetes (T2D). The treatment and prevention of obesity and associated metabolic disorders present great medical challenges. A major therapeutic goal in T2D is to control blood glucose levels, which can be achieved by pharmacological and nonpharmacological measures. The latter include increased physical activity and reduction of body fat mass by limiting dietary caloric content. Low-calorie diets (LCDs) involve a reduction in daily caloric intake by 25% to 30%. LCDs should be individualized depending on the patient's energy requirements, the severity of the obesity, and any accompanying diseases and treatments. Intermittent fasting (IF) involves caloric restriction for one or several days a week, or every day as the prolongation of the overnight fast. The results of recent clinical trials have shown that LCDs and intermittent fasting in patients with obesity (including those with coexisting T2D) can lead to a reduction in body fat mass and metabolic parameter improvements. These beneficial effects arise not only from the loss of body mass, but also from the activation of metabolic pathways specific to fasting conditions. However, the paucity of large-scale randomized controlled trials makes it difficult to prescribe LCDs or IF as reliable, routine methods for successful and stable weight loss.
C1 [Zubrzycki, A.; Kmiec, Z.; Wronska, A.] Med Univ Gdansk, Dept Histol, 1 Debinki St, PL-80211 Gdansk, Poland.
   [Cierpka-Kmiec, K.] Med Univ Gdansk, Dept Hypertens & Diabetol, Gdansk, Poland.
C3 Fahrenheit Universities; Medical University Gdansk; Fahrenheit
   Universities; Medical University Gdansk
RP Wronska, A (corresponding author), Med Univ Gdansk, Dept Histol, 1 Debinki St, PL-80211 Gdansk, Poland.
EM agata.wronska@gumed.edu.pl
RI Wronska, Agata/GMW-4913-2022; Zubrzycki, Adrian/N-5937-2018
OI Zubrzycki, Adrian/0000-0002-4303-5620
FU Medical University of Gdansk, Poland [ST-12]
FX The publication of this paper has been supported by statutory grant
   ST-12 of the Medical University of Gdansk, Poland.
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NR 118
TC 90
Z9 100
U1 1
U2 75
PU POLISH PHYSIOLOGICAL SOC
PI GRZEGORZECKA
PA JAGIELLONIAN UNIV SCHOOL MED, INST PHYSIOLOGY, 31-531 KRAKOW, 16
   GRZEGORZECKA, POLAND
SN 0867-5910
J9 J PHYSIOL PHARMACOL
JI J. Physiol. Pharmacol.
PD OCT
PY 2018
VL 69
IS 5
BP 663
EP 683
DI 10.26402/jpp.2018.5.02
PG 21
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA HJ3LN
UT WOS:000457073300002
PM 30683819
DA 2025-06-11
ER

PT J
AU Dhanda, N
   Taheri, S
AF Dhanda, N.
   Taheri, S.
TI A narrative review of obesity and hearing loss
SO INTERNATIONAL JOURNAL OF OBESITY
LA English
DT Review
ID TYPE-2 DIABETES-MELLITUS; OXIDATIVE STRESS; METABOLIC SYNDROME;
   ADIPOSE-TISSUE; RISK-FACTORS; INNER-EAR; AGE; IMPAIRMENT; ADULTS;
   DISCRIMINATION
AB The comorbidities related to obesity are already extensive, but as the prevalence of obesity increases globally, so do the number of its associated conditions. The relationship between hearing impairment and obesity is a relatively recent research interest, but is significant as both conditions have the ability to substantially reduce an individual's quality of life both physically and psychologically. Obesity has a significant effect on vascular function, and this may have an impact on highly vascular organs such as the auditory system. This review aims to provide an overview of the existing literature surrounding the association between hearing loss and obesity, in order to emphasise these two highly prevalent conditions, and to identify areas of further investigation. Our literature search identified a total of 298 articles with 11 articles of relevance to the review. The existing literature in this area is sparse, with interest ranging from obesity and its links to age-related hearing impairment (ARHI) and sudden sensorineural hearing loss (SSNHL), to animal models and genetic syndromes that incorporate both disorders. A key hypothesis for the underlying mechanism for the relationship between obesity and hearing loss is that of vasoconstriction in the inner ear, whereby strain on the capillary walls due to excess adipose tissue causes damage to the delicate inner ear system. The identified articles in this review have not established a causal relationship between obesity and hearing impairment. Further research is required to examine the emerging association between obesity and hearing impairment, and identify its potential underlying mechanisms.
C1 [Dhanda, N.; Taheri, S.] Qatar Fdn, Weill Cornell Med Qatar, Educ City, Clin Res Core, Doha, Qatar.
   [Taheri, S.] Weill Cornell Med, Dept Med, New York, NY USA.
C3 Qatar Foundation (QF); Weill Cornell Medical College Qatar; Cornell
   University; Weill Cornell Medicine
RP Taheri, S (corresponding author), Qatar Fdn, Educ City, Weill Cornell Med Qatar, POB 24144, Doha, Qatar.
EM staheri@me.com
RI Taheri, Shahrad/O-9721-2016
OI Dhanda, Nisha/0000-0003-1988-454X
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NR 60
TC 52
Z9 53
U1 2
U2 16
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0307-0565
EI 1476-5497
J9 INT J OBESITY
JI Int. J. Obes.
PD JUL
PY 2017
VL 41
IS 7
BP 1066
EP 1073
DI 10.1038/ijo.2017.32
PG 8
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA EZ8FD
UT WOS:000404959200011
PM 28163314
DA 2025-06-11
ER

PT J
AU Todd, MA
   Shkolnikov, VM
   Goldman, N
AF Todd, Megan A.
   Shkolnikov, Vladimir M.
   Goldman, Noreen
TI Why are well-educated Muscovites more likely to survive? Understanding
   the biological pathways
SO SOCIAL SCIENCE & MEDICINE
LA English
DT Article
DE Russia; Socioeconomic status; Biomarkers; Mortality; Aging;
   Inflammation; Education
ID HEART-RATE-VARIABILITY; C-REACTIVE PROTEIN; CARDIOVASCULAR-DISEASE;
   SOCIOECONOMIC-STATUS; RISK-FACTORS; RUSSIAN-FEDERATION; PREDICTS
   MORTALITY; METABOLIC SYNDROME; EDUCATIONAL-LEVEL; ELDERLY SUBJECTS
AB There are large socioeconomic disparities in adult mortality in Russia, although the biological mechanisms are not well understood. With data from the study of Stress, Aging, and Health in Russia (SAHR), we use Gompertz hazard models to assess the relationship between educational attainment and mortality among older adults in Moscow and to evaluate biomarkers associated with inflammation, neuroendocrine function, heart rate variability, and clinical cardiovascular and metabolic risk as potential mediators of that relationship. We do this by assessing the extent to which the addition of biomarker variables into hazard models of mortality attenuates the association between educational attainment and mortality. We find that an additional year of education is associated with about 5% lower risk of age specific all-cause and cardiovascular mortality. Inflammation biomarkers are best able to account for this relationship, explaining 25% of the education-all-cause mortality association, and 35% of the education-cardiovascular mortality association. Clinical markers perform next best, accounting for 13% and 23% of the relationship between education and all-cause and cardiovascular mortality, respectively. Although heart rate biomarkers are strongly associated with subsequent mortality, they explain very little of the education-mortality link. Neuroendocrine biomarkers fail to account for any portion of the link. These findings suggest that inflammation may be important for understanding mortality disparities by socioeconomic status. (C) 2016 Published by Elsevier Ltd.
C1 [Todd, Megan A.; Goldman, Noreen] Princeton Univ, Off Populat Res, Wallace Hall, Princeton, NJ 08544 USA.
   [Todd, Megan A.; Goldman, Noreen] Princeton Univ, Woodrow Wilson Sch Publ & Int Affairs, Wallace Hall, Princeton, NJ 08544 USA.
   [Shkolnikov, Vladimir M.] Max Planck Inst Demog Res, Konrad Zuse Str 1, D-18057 Rostock, Germany.
   [Shkolnikov, Vladimir M.] New Econ Sch, Ul Novaya 100A, Moscow 143026, Skolkovo, Russia.
C3 Princeton University; Princeton University; Max Planck Society; New
   Economic School
RP Todd, MA (corresponding author), Columbia Univ, Columbia Aging Ctr, 722 W 168th St,Room 410, New York, NY 10032 USA.
EM mt3101@columbia.edu; shkolnikov@demogr.mpg.de; ngoldman@princeton.edu
RI Shkolnikov, Vladimir/D-2986-2017
OI Shkolnikov, Vladimir/0000-0003-2259-5423; Goldman,
   Noreen/0000-0003-2865-9491
FU NIA NIH HHS [R01 AG026786] Funding Source: Medline; NICHD NIH HHS [P2C
   HD047879, R24 HD047879] Funding Source: Medline
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NR 93
TC 7
Z9 7
U1 1
U2 6
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0277-9536
J9 SOC SCI MED
JI Soc. Sci. Med.
PD MAY
PY 2016
VL 157
BP 138
EP 147
DI 10.1016/j.socscimed.2016.02.041
PG 10
WC Public, Environmental & Occupational Health; Social Sciences, Biomedical
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; Biomedical Social Sciences
GA DL7GL
UT WOS:000375808900017
PM 27085072
OA Green Accepted
DA 2025-06-11
ER

PT J
AU D'Elia, E
   Vaduganathan, M
   Gori, M
   Gavazzi, A
   Butler, J
   Senni, M
AF D'Elia, Emilia
   Vaduganathan, Muthiah
   Gori, Mauro
   Gavazzi, Antonello
   Butler, Javed
   Senni, Michele
TI Role of biomarkers in cardiac structure phenotyping in heart failure
   with preserved ejection fraction: critical appraisal and practical use
SO EUROPEAN JOURNAL OF HEART FAILURE
LA English
DT Review
DE Biomarkers; Cardiac structure phenotypes; Heart failure with preserved
   ejection fraction
ID CORONARY-ARTERY-DISEASE; NEPRILYSIN INHIBITOR LCZ696; DIASTOLIC
   DYSFUNCTION; MYOCARDIAL FIBROSIS; TROPONIN-T; CARDIOVASCULAR-DISEASE;
   CIRCULATING MICRORNAS; HYPERTENSIVE PATIENTS; METABOLIC SYNDROME;
   PROGNOSTIC IMPACT
AB Heart failure (HF) with preserved ejection fraction (HFpEF) is a heterogeneous clinical syndrome characterized by cardiovascular, metabolic, and pro-inflammatory diseases associated with advanced age and extracardiac comorbidities. All of these conditions finally lead to impairment of myocardial structure and function. The large phenotypic heterogeneity of HFpEF from pathophysiological underpinnings presents a major hurdle to HFpEF therapy. The new therapeutic approach in HFpEF should be targeted to each HF phenotype, instead of the one-size-fits-all' approach, which has not been successful in clinical trials. Unless the structural and biological determinants of the failing heart are deeply understood, it will be impossible to appropriately differentiate HFpEF patients, identify subtle myocardial abnormalities, and finally reverse abnormal cardiac function. Based on evidence from endomyocardial biopsies, some of the specific cardiac structural phenotypes to be targeted in HFpEF may be represented by myocyte hypertrophy, interstitial fibrosis, myocardial inflammation associated with oxidative stress, and coronary disease. Once the diagnosis of HFpEF has been established, a potential approach could be to use a panel of biomarkers to identify the main cardiac structural HFpEF phenotypes, guiding towards more appropriate therapeutic strategies. Accordingly, the purpose of this review is to investigate the potential role of biomarkers in identifying different cardiac structural HFpEF phenotypes and to discuss the merits of a biomarker-guided strategy in HFpEF.
C1 [D'Elia, Emilia; Gori, Mauro; Senni, Michele] Azienda Osped Papa Giovanni XXIII, Dipartimento Cardiovasc, Bergamo, Italy.
   [Vaduganathan, Muthiah] Brigham & Womens Hosp, Heart & Vasc Ctr, Boston, MA 02115 USA.
   [Vaduganathan, Muthiah] Harvard Univ, Sch Med, Boston, MA USA.
   [Gavazzi, Antonello] Azienda Osped Papa Giovanni XXIII, FROM Fdn Ric, Bergamo, Italy.
   [Butler, Javed] SUNY Stony Brook, Div Cardiol, Stony Brook, NY 11794 USA.
C3 ASST Papa Giovanni XXIII; Harvard University; Harvard University Medical
   Affiliates; Brigham & Women's Hospital; Harvard University; Harvard
   Medical School; ASST Papa Giovanni XXIII; State University of New York
   (SUNY) System; Stony Brook University
RP Senni, M (corresponding author), Azienda Osped Papa Giovanni XXIII, Dipartimento Cardiovasc, Bergamo, Italy.
EM msenni@hpg23.it
RI Butler, Javed/AEW-5002-2022; GORI, MAURO/J-9684-2018; SENNI,
   MICHELE/J-9380-2018
OI GORI, MAURO/0000-0001-5509-8867; D'Elia, Emilia/0000-0002-6682-0074;
   SENNI, MICHELE/0000-0001-5502-7882
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NR 95
TC 81
Z9 81
U1 0
U2 18
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1388-9842
EI 1879-0844
J9 EUR J HEART FAIL
JI Eur. J. Heart Fail.
PD DEC
PY 2015
VL 17
IS 12
BP 1231
EP 1239
DI 10.1002/ejhf.430
PG 9
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA CY4YV
UT WOS:000366415700008
PM 26493383
OA Bronze
DA 2025-06-11
ER

PT J
AU Quinkler, M
   Beuschlein, F
   Hahner, S
   Meyer, G
   Schöfl, C
   Stalla, GK
AF Quinkler, Marcus
   Beuschlein, Felix
   Hahner, Stefanie
   Meyer, Gesine
   Schoefl, Christof
   Stalla, Guenter K.
TI Adrenal Cortical Insufficiency-a Life Threatening Illness With Multiple
   Etiologies
SO DEUTSCHES ARZTEBLATT INTERNATIONAL
LA English
DT Review
ID MODIFIED-RELEASE HYDROCORTISONE; SUBJECTIVE HEALTH-STATUS;
   GLUCOCORTICOID REPLACEMENT; ADDISONS-DISEASE; THERAPEUTIC MANAGEMENT;
   PREMATURE MORTALITY; ADULT PATIENTS; SHORT-TERM; CORTISOL; STRATEGY
AB Background: The clinical signs of adrenal cortical insufficiency (incidence, ca. 25 per million per year; prevalence, ca. 400 per million) are nonspecific, and misdiagnoses are therefore common. Glucocorticoid substitution therapy has been in use for 50 years but is not a wholly adequate treatment. Our understanding of this disease remains incomplete in many ways.
   Methods: We selectively searched the Medline database for publications on adrenal cortical insufficiency, with particular attention to studies from the year 2000 onward (search terms: "adrenal insufficiency" or "Addison's disease" or "hypopituitarism").
   Results: Hydrocortisone substitution therapy is often given in doses of 10-25 mg/day, timed according to the circadian rhythm. Gastrointestinal and other, febrile infections account for 30-50% of life-threatening adrenocortical crises. Such crises affect 8 of 100 persons with adrenal cortical insufficiency per year and must be treated by the immediate administration of glucocorticoids and fluids. When persons with adrenal cortical insufficiency are acutely ill or are otherwise under unusual stress, they may need additional amounts of hydrocortisone, often in the range of 5-10 mg but occasionally as high as 200 mg. The sustained administration of excessive amounts of steroid can shorten patients' lives by several years. Inappropriate substitution therapy can cause other major medical conditions, such as metabolic syndrome and osteoporosis.
   Conclusion: Important measures for the prevention of adrenocortical crises include improved care by treating physicians, education of patients and their families, the provision of emergency identifying documents, and the prescription of glucocorticoid emergency kits.
C1 [Quinkler, Marcus] Charite, Dept Endocrinol & Metab Dis, D-10117 Berlin, Germany.
   [Beuschlein, Felix] Univ Munich, Klinikum Ludwig Maximilian, Med Klin, Endocrine Res Unit, D-81377 Munich, Germany.
   [Hahner, Stefanie] Univ Klinikum Wurzburg, Dept Internal Med 1, Dept Endocrinol, Wurzburg, Germany.
   [Meyer, Gesine] Goethe Univ Frankfurt, Dept Internal Med, Div Endocrinol, D-60054 Frankfurt, Germany.
   [Schoefl, Christof] Univ Erlangen Nurnberg, Univ Klinikum Erlangen, Dept Med Gastroenterol Pneumol & Endocrinol 1, Erlangen, Germany.
   [Stalla, Guenter K.] Max Planck Inst Psychiat, Dept Clin Neuroendocrinol, D-80804 Munich, Germany.
C3 Berlin Institute of Health; Free University of Berlin; Humboldt
   University of Berlin; Charite Universitatsmedizin Berlin; University of
   Munich; University of Wurzburg; Goethe University Frankfurt; University
   of Erlangen Nuremberg; Max Planck Society
RP Quinkler, M (corresponding author), Charite, Klin Innere Med Schwerpunkt Endokrinol Diabet & S, Charite Campus Mitte,Charitepl 1, D-10117 Berlin, Germany.
EM marcus.quinkler@charite.de
RI Meyer, Gesine/ABD-7219-2021; Beuschlein, Felix/N-1282-2018
OI Beuschlein, Felix/0000-0001-7826-3984; Hahner,
   Stefanie/0000-0003-1616-8986; Meyer, Gesine/0000-0001-5639-4537;
   Quinkler, Marcus/0000-0003-4028-1671; Stalla,
   Guenter/0000-0002-1975-3294
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NR 52
TC 48
Z9 51
U1 0
U2 13
PU DEUTSCHER AERZTE-VERLAG GMBH
PI COLOGNE
PA DIESELSTRABE 2, POSTFACH 400265, D-50859 COLOGNE, GERMANY
SN 1866-0452
J9 DTSCH ARZTEBL INT
JI Dtsch. Arztebl. Int.
PD DEC 23
PY 2013
VL 110
IS 51-52
BP 882
EP +
DI 10.3238/arztebl.2013.0882
PG 9
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 291ZS
UT WOS:000329872000003
PM 24529304
OA Green Published
DA 2025-06-11
ER

PT J
AU Evans, JF
   Islam, S
   Urade, Y
   Eguchi, N
   Ragolia, L
AF Evans, Jodi F.
   Islam, Shahidul
   Urade, Yoshihiro
   Eguchi, Naomi
   Ragolia, Louis
TI The lipocalin-type prostaglandin D2 synthase knockout mouse
   model of insulin resistance and obesity demonstrates early
   hypothalamic-pituitary-adrenal axis hyperactivity
SO JOURNAL OF ENDOCRINOLOGY
LA English
DT Article
DE lipocalin-type prostaglandin D-2 synthase; metabolic syndrome;
   hypercholesterolemia; hyperglycemia; hypothalamic-pituitary-adrenal axis
   (HPA axis)
ID HIGH-FAT DIET; MICE; STRESS; ATHEROSCLEROSIS; SYSTEM; SLEEP;
   HYPERGLYCEMIA; ADIPOGENESIS; EXPRESSION; CELLS
AB Obesity and diabetes are closely associated with hyperactivation of the hypothalamic-pituitary-adrenal (HPA) axis. In this study, the diet-induced obese C57BL/6 mouse was used to test the hypothesis that chronically elevated metabolic parameters associated with the development of obesity such as cholesterol and glucose can aggravate basal HPA axis activity. Because the lipocalin-type prostaglandin D-2 synthase (L-PGDS) knockout (KO) mouse is a model of accelerated insulin resistance, glucose intolerance, and obesity, it was further hypothesized that HPA activity would be greater in this model. Starting at 8 weeks of age, the L-PGDS KO and C57BL/6 mice were maintained on a low-fat or high-fat diet. After 20 or 37 weeks, fasting metabolic parameters and basal HPA axis hormones were measured and compared between genotypes. Correlation analyses were performed to identify associations between obesity-related chronic metabolic changes and changes in the basal activity of the HPA axis. Our results have identified strong positive correlations between total cholesterol, LDL-cholesterol, glucose, and HPA axis hormones that increase with age in the C57BL/6 mice. These data confirm that obesity-related elevations in cholesterol and glucose can heighten basal HPA activity. Additionally, the L-PGDS KO mice show early elevations in HPA activity with no age-related changes relative to the C57BL/6 mice.
C1 [Evans, Jodi F.; Ragolia, Louis] Winthrop Univ Hosp, Biomed Res Core, Mineola, NY 11501 USA.
   [Evans, Jodi F.; Ragolia, Louis] SUNY Stony Brook, Sch Med, Stony Brook, NY 11794 USA.
   [Islam, Shahidul] Winthrop Univ Hosp, Mineola, NY 11501 USA.
   [Urade, Yoshihiro] Osaka Biosci Inst, Dept Mol Behav Biol, Osaka 5650874, Japan.
C3 Winthrop University Hospital; State University of New York (SUNY)
   System; Stony Brook University; Winthrop University Hospital
RP Ragolia, L (corresponding author), Winthrop Univ Hosp, Biomed Res Core, 222 Stn Plaza North,Suite 505-B, Mineola, NY 11501 USA.
EM lragolia@winthrop.org
RI Islam, Shahidul/N-5897-2013; Ragolia, Louis/AAW-2383-2021
OI Evans, Jodi/0000-0002-6404-7604; Islam, Shahidul/0000-0002-9385-101X;
   Ragolia, Louis/0000-0002-8292-5159
FU Medical Education Fund (Winthrop U Hospital); National Institutes of
   Health [K99HL091116]
FX This work was supported by the Medical Education Fund (Winthrop U
   Hospital) and the National Institutes of Health (K99HL091116).
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NR 36
TC 14
Z9 17
U1 0
U2 14
PU BIOSCIENTIFICA LTD
PI BRISTOL
PA EURO HOUSE, 22 APEX COURT WOODLANDS, BRADLEY STOKE, BRISTOL BS32 4JT,
   ENGLAND
SN 0022-0795
J9 J ENDOCRINOL
JI J. Endocrinol.
PD FEB
PY 2013
VL 216
IS 2
BP 169
EP 180
DI 10.1530/JOE-12-0275
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 100VU
UT WOS:000315733400008
PM 23151358
OA Bronze
DA 2025-06-11
ER

PT J
AU Loria, P
   Lonardo, A
   Anania, F
AF Loria, Paola
   Lonardo, Amedeo
   Anania, Frank
TI Liver and diabetes. A vicious circle
SO HEPATOLOGY RESEARCH
LA English
DT Review
DE cholangiocarcinoma; cirrhosis; epidemiology; hepatocellular carcinoma;
   management; natural history
ID NONALCOHOLIC FATTY LIVER; NECROSIS-FACTOR-ALPHA; HEPATIC
   INSULIN-RESISTANCE; GAMMA-GLUTAMYL-TRANSFERASE; UNFOLDED PROTEIN
   RESPONSE; METABOLIC SYNDROME; ADIPOSE-TISSUE; RISK-FACTORS; FOLLOW-UP;
   HEPATOCELLULAR-CARCINOMA
AB The complex and bi-directional relationship linking the liver and diabetes has recently gained intense new interest. This critical review of the published work aims to highlight the most recent basic and clinical data underlying the development of type 2 diabetes, in those with non-alcoholic fatty liver disease. Moreover, the potentially detrimental effects of type 2 diabetes in liver injury are also discussed in each of the two sections of the present paper. Fatty liver and diabetes share insulin resistance as their chief pathogenic determinant. The roles of the hypothalamus, the intestinal microbiome, white adipose tissue and inflammation are discussed in detail. Molecular insights into hepatocyte insulin resistance as the initiator of systemic insulin resistance are also presented with full coverage of the danger of fatty acids. Lipotoxicity, apoptosis, lipoautophagy, endoplasmic reticular stress response and recent developments in genetics are discussed. Closing the circle, special emphasis is given to biochemical pathways and clinical evidence supporting the role of type 2 diabetes as a risk factor for the development of progressive liver disease, including non-alcoholic steatohepatitis, cirrhosis and primary liver cancer. In conclusion, data support non-alcoholic fatty liver disease as a risk factor for the development of type 2 diabetes which is, in turn, a major contributor to progressive liver disease. This pathway leading from fatty liver to type 2 diabetes and back from the latter to the progressive liver disease is a vicious circle.
C1 [Loria, Paola; Lonardo, Amedeo] Univ Modena & Reggio Emilia, Modena, Italy.
   [Anania, Frank] Emory Univ, Sch Med, Atlanta, GA USA.
C3 Universita di Modena e Reggio Emilia; Emory University
RP Loria, P (corresponding author), Nuovo Osped Civile St Agostino Estense NOCSAE, Operating Unit Internal Med, Via Giardini 1135, I-41100 Baggiovara Modena, Italy.
EM paola.loria@unimore.it
RI Lonardo, Amedeo/I-5911-2019
OI Lonardo, Amedeo/0000-0001-9886-0698
FU NIDDK NIH HHS [R01 DK062092, R01 DK075397, R56 DK062092] Funding Source:
   Medline
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NR 144
TC 168
Z9 183
U1 0
U2 56
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1386-6346
EI 1872-034X
J9 HEPATOL RES
JI Hepatol. Res.
PD JAN
PY 2013
VL 43
IS 1
BP 51
EP 64
DI 10.1111/j.1872-034X.2012.01031.x
PG 14
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 074NQ
UT WOS:000313819700004
PM 23332087
OA Bronze, Green Accepted
DA 2025-06-11
ER

PT J
AU Ozkurt, S
   Karavelioglu, Y
   Musmul, A
AF Ozkurt, Sultan
   Karavelioglu, Yusuf
   Musmul, Ahmet
TI Echocardiographic evaluation of epicardial adipose tissue in
   non-diabetic, non-hypertensive hemodialysis patients
SO RENAL FAILURE
LA English
DT Article
DE Chronic renal failure; diabetes mellitus; epicardial adipose tissue;
   hemodialysis; hypertension
ID CORONARY-ARTERY CALCIFICATION; CARDIOVASCULAR-DISEASE; METABOLIC
   SYNDROME; KIDNEY-DISEASE; FAT THICKNESS; RISK; ASSOCIATION; DYSFUNCTION;
   POPULATION; STRESS
AB Purpose: It has been found out that the epicardial adipose tissue (EAT) measured by echocardiography is related with various metabolic parameters. Being accepted as the new cardiovascular risk indicator, there have been few studies on EAT in relation to the patients with end-stage renal failure. In our study, we aim to evaluate EAT and carotid intima media thickness (CIMT) in non-diabetic, non-hypertensive hemodialysis (HD) patients. Methods: Our study recruited 47 non-diabetic, non-hypertensive HD patients (22 males, 25 females, median age 54 (44.3-60.8) years) and an age-gender matched control group consisting 41 healthy subjects (17 males, 24 females, median age 52 (48-56) years). In all patients, EAT was measured by echocardiography and CIMT by ultrasonography; and routine laboratory parameters were studied. Results: In our study, we obtained laboratory findings matching with the profiles of uremic patients among HD patients and CIMT values of HD patients are significantly higher than that of the control group [0.79 (0.64-0.93) vs. 0.6 (0.53-0.68) p<0.001], and EAT values are similar [0.5 (0.33-0.6) vs. 0.4 (0.4-0.53) p>0.05]. Conclusions: EAT is not a cardiovascular risk indicator in HD patients without diabetes mellitus and hypertension. Besides, echocardiographic measurement of EAT is easy, non-invasive, cheap and credible method.
C1 [Ozkurt, Sultan] Hitit Univ Corum Educ & Res Hosp, Div Nephrol, TR-19100 Corum, Turkey.
   [Karavelioglu, Yusuf] Hitit Univ, Corum Educ & Res Hosp, Dept Cardiol, Corum, Turkey.
   [Musmul, Ahmet] Eskisehir Osmangazi Univ, Dept Stat, Fac Med, Eskisehir, Turkey.
C3 Hitit University; Corum Training & Research Hospital; Hitit University;
   Eskisehir Osmangazi University
RP Ozkurt, S (corresponding author), Hitit Univ Corum Educ & Res Hosp, Div Nephrol, TR-19100 Corum, Turkey.
EM dr.s.guvenir@hotmail.com
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NR 26
TC 6
Z9 6
U1 0
U2 9
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0886-022X
EI 1525-6049
J9 RENAL FAILURE
JI Ren. Fail.
PY 2013
VL 35
IS 6
BP 891
EP 895
DI 10.3109/0886022X.2013.794682
PG 5
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 161MS
UT WOS:000320197800021
PM 23713741
DA 2025-06-11
ER

PT J
AU Wickman, C
   Kramer, H
AF Wickman, Christopher
   Kramer, Holly
TI Obesity and Kidney Disease: Potential Mechanisms
SO SEMINARS IN NEPHROLOGY
LA English
DT Review
DE Obesity; chronic kidney disease; adiposity; caloric restriction
ID BODY-MASS INDEX; WEIGHT-LOSS; WAIST CIRCUMFERENCE; ABDOMINAL OBESITY;
   GLOMERULAR HYPERFILTRATION; CALORIE RESTRICTION; RENAL HEMODYNAMICS;
   METABOLIC SYNDROME; OLDER-PEOPLE; ALL-CAUSE
AB Assessment of adiposity should include measurements of both body mass index and waist circumference. The prevalence of obesity, based on a body mass index of 30 kg/m(2) or greater, has increased substantially over the past 2 decades in Western societies. Obesity remains the number one preventable risk factor for chronic kidney disease because obesity largely mediates diabetes and hypertension, the 2 most common etiologies for end-stage kidney disease. However, obesity itself likely has independent effects on renal hemodynamics and individuals with a low number of nephrons are likely to be the most susceptible to these changes. Multiple mechanisms have been postulated whereby obesity directly impacts kidney disease including hyperfiltration, increased glomerular capillary wall tension, and podocyte stress. Weight loss reduces glomerular filtration rate and effective renal plasma flow along with proteinuria, but these changes are most notable after bariatric surgery in adults with morbid obesity. Aside from adiposity itself, the high caloric intake that leads to obesity also may heighten chronic kidney disease risk via the circuitous loop between Sirt1 and adiponectin and podocyte effacement. Sirt1 is a nicotinamide adenine dinucleotide+dependent deacteylase that is up-regulated in the setting of caloric restriction. Sirt1 expression modulates adiponectin levels that in turn appear to influence podocyte effacement. Clinical trials are needed to assess the benefits and risks of intentional weight loss on kidney disease measures and progression. Semin Nephrol 33:14-22 (C) 2013 Elsevier Inc. All rights reserved.
C1 [Wickman, Christopher; Kramer, Holly] Loyola Univ Chicago, Div Nephrol & Hypertens, Maywood, IL 60153 USA.
   [Kramer, Holly] Loyola Univ Chicago, Dept Prevent Med & Epidemiol, Maywood, IL 60153 USA.
C3 Loyola University Chicago; Loyola University Chicago
RP Kramer, H (corresponding author), Loyola Univ Chicago, Dept Prevent Med & Epidemiol, Hlth Sci Campus,2160 S 1st Ave,2160 1st Ave, Maywood, IL 60153 USA.
EM hkramer@lumc.edu
OI Kramer, Holly/0000-0002-6374-837X
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NR 91
TC 152
Z9 160
U1 0
U2 12
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0270-9295
EI 1558-4488
J9 SEMIN NEPHROL
JI Semin. Nephrol.
PD JAN
PY 2013
VL 33
IS 1
BP 14
EP 22
DI 10.1016/j.semnephrol.2012.12.006
PG 9
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 090VA
UT WOS:000315006900003
PM 23374890
DA 2025-06-11
ER

PT J
AU Almonacid-Urrego, CC
   Sánchez-Campos, S
   Tuñón, MJ
   González-Gallego, J
AF Almonacid-Urrego, C. C.
   Sanchez-Campos, S.
   Tunon, M. J.
   Gonzalez-Gallego, J.
TI Non-Alcoholic Steatohepatitis: What Can We Learn from Animal Models?
SO CURRENT MEDICINAL CHEMISTRY
LA English
DT Review
DE Animal models; atherogenesis; dietary models; genetic models;
   non-alcoholic steatohepatitis
ID FATTY LIVER-DISEASE; TRIGLYCERIDE TRANSFER PROTEIN; DIET-INDUCED
   STEATOHEPATITIS; HEPATIC LIPID-ACCUMULATION; KAPPA-B ACTIVATION;
   INSULIN-RESISTANCE; PPAR-ALPHA; OXIDATIVE STRESS; GENE-EXPRESSION;
   MOUSE-LIVER
AB Non-alcoholic fatty liver disease (NAFLD) is one of the most frequent causes of abnormal liver function and correlates with central adiposity, obesity, insulin resistance, the metabolic syndrome and type 2 diabetes mellitus. The pathological spectrum of NAFLD ranges from fatty liver to non-alcoholic steatohepatitis (NASH), advanced fibrosis, cirrhosis, and even hepatocellular carcinoma. Though NAFLD and NASH are becoming a major public health problem, ethical constraints on obtaining human liver tissue limit the interpretability of the data and the ability to delineate cause and effect from complex, interactive disease pathogenic pathways. Animal models of NASH can provide critical information leading to identify potential drug targets and to understand their molecular mechanisms, and are platforms for compound screening in drug development and for the assessment of novel therapeutic strategies. This review is aimed to offer an updated overview of the nutritional, genetic and pharmacologic animal models of NASH. Though the information derived from these models has clear relevance for the comprehension of the molecular basis of human disease, most of them fail to reproduce the full spectrum of liver pathology and the metabolic context that characterizes human NASH. Consequently, it is necessary to establish animal models that can best mimic the actual etiology, progression, and pathogenesis of the disease, and prove effectiveness for examining and selecting compounds with potential therapeutic benefit in NASH.
C1 [Gonzalez-Gallego, J.] Univ Leon, Inst Biomed IBIOMED, E-24071 Leon, Spain.
   Univ Leon, CIBERehd, E-24071 Leon, Spain.
   [Almonacid-Urrego, C. C.] Cundinamarca Univ, Res Grp ECZA, Program Bacteriol & Clin Lab, Colegio Mayor, Bogota, Colombia.
C3 Universidad de Leon; Universidad de Leon; CIBER - Centro de
   Investigacion Biomedica en Red; CIBEREHD; Universidad Colegio Mayor de
   Cundinamarca; Universidad de Cundinamarca
RP González-Gallego, J (corresponding author), Univ Leon, Inst Biomed IBIOMED, Campus Univ, E-24071 Leon, Spain.
EM jgonga@unileon.es
RI Gonzalez-Gallego, Javier/D-8219-2012; Tuñón, María/L-2456-2017;
   Sanchez-Campos, Sonia/F-9654-2015
OI Tunon, Maria Jesus/0000-0001-7827-5918; Gonzalez-Gallego,
   Javier/0000-0002-4386-9342; Sanchez-Campos, Sonia/0000-0003-2672-734X
FU Ministerio de Ciencia y Tecnologia, Plan Nacional de Investigacion
   Cientifica, Desarrollo e Innovacion Tecnologica [BFU2010-15784]; Junta
   de Castilla y Leon, Spain [GRS 482/A/10]; Instituto de Salud Carlos III,
   Spain
FX This study was supported in part by the Ministerio de Ciencia y
   Tecnologia, Plan Nacional de Investigacion Cientifica, Desarrollo e
   Innovacion Tecnologica (Grant BFU2010-15784) and from Junta de Castilla
   y Leon (GRS 482/A/10), Spain. CIBERehd is financed by the Instituto de
   Salud Carlos III, Spain. CCAU is a member of the Asociacion Cientifica
   Latina (ASCILA).
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NR 156
TC 13
Z9 13
U1 0
U2 17
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 0929-8673
EI 1875-533X
J9 CURR MED CHEM
JI Curr. Med. Chem.
PD MAR
PY 2012
VL 19
IS 9
BP 1389
EP 1404
DI 10.2174/092986712799462586
PG 16
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Pharmacology &
   Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
GA 897IC
UT WOS:000300641400016
PM 22360487
DA 2025-06-11
ER

PT J
AU Poursafa, P
   Kelishadi, R
   Amini, A
   Amini, A
   Amin, MM
   Lahijanzadeh, M
   Modaresi, M
AF Poursafa, Parinaz
   Kelishadi, Roya
   Amini, Amin
   Amini, Abasgholi
   Amin, Mohammad Mehdi
   Lahijanzadeh, Mohammadreza
   Modaresi, Mohammadreza
TI Association of air pollution and hematologic parameters in children and
   adolescents
SO JORNAL DE PEDIATRIA
LA English
DT Article
ID METABOLIC SYNDROME; OXIDATIVE STRESS; CHRONIC EXPOSURE; MARKERS;
   INFLAMMATION; COMPONENTS
AB Objective: To assess the relationship between air pollution and hematologic parameters in a population-based sample of children and adolescents.
   Methods: This cross-sectional study was conducted in 2009-2010 among school students randomly selected from different areas of Isfahan city, the second largest and most air-polluted city in Iran. The association of air pollutant levels with hemoglobin, platelets, red and white blood cells (RBC and WBC, respectively) was determined by multiple linear and logistic regression analyses, after adjustment for age, gender, anthropometric measures, meteorological factors, and dietary and physical activity habits.
   Results: The study participants consisted of 134 students (48.5% boys) with a mean age of 13.10 +/- 2.21 years. While the mean Pollutant Standards Index (PSI) was at moderate level, the mean particulate matter <= 10 mu m (PM10) was more than twice the normal level. Multiple linear regression analysis showed that PSI and most air pollutants, notably PM10, had significant negative relationship with hemoglobin and RBC count, and positive significant relationship with WBC and platelet counts. The odds ratio of elevated WBC increased as the quartiles of PM10, ozone and PSI increased, however these associations reached significant level only in the highest quartile of PM10 and PSI. The corresponding figures for hemoglobin and RBC were in opposite direction.
   Conclusions: The association of air pollutants with hematologic parameters and a possible pro-inflammatory state is highlighted. The presence of these associations with PM10 in a moderate mean PSI level underscores the necessity to re-examine environmental health policies for the pediatric age group.
C1 [Kelishadi, Roya; Modaresi, Mohammadreza] Isfahan Univ Med Sci, Child Hlth Promot Res Ctr, Dept Pediat, Esfahan, Iran.
   [Amin, Mohammad Mehdi] Isfahan Univ Med Sci, Environm Res Ctr, Dept Environm Hlth Engn, Esfahan, Iran.
   [Poursafa, Parinaz] Islamic Azad Univ, Sci & Res Branch, Environm Protect Dept, Tehran, Iran.
   [Amini, Amin] Islamic Azad Univ, Najafabad Branch, Esfahan, Iran.
   [Amini, Abasgholi] Isfahan Univ Med Sci, Sch Med, Dept Pediat, Esfahan, Iran.
   [Lahijanzadeh, Mohammadreza] Isfahan Prov Directorate Environm Protect, Environm Protect Dept, Esfahan, Iran.
C3 Isfahan University of Medical Sciences; Isfahan University of Medical
   Sciences; Islamic Azad University; Islamic Azad University; Isfahan
   University of Medical Sciences
RP Kelishadi, R (corresponding author), Isfahan Univ Med Sci, Child Hlth Promot Res Ctr, Dept Pediat, Hezar Jerib Ave, Esfahan, Iran.
EM kroya@aap.net
RI amin, mohammadmehdi/A-1587-2018; Kelishadi, Roya/E-6154-2012; Poursafa,
   Parinaz/U-2924-2017
OI amin, mohammadmehdi/0000-0001-5758-7277; Kelishadi,
   Roya/0000-0001-7455-1495; Poursafa, Parinaz/0000-0002-8067-4122
CR [Anonymous], ZINC HUMAN BIOL
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NR 32
TC 32
Z9 33
U1 2
U2 19
PU SOC BRASIL PEDIATRIA
PI RIO DE JANEIRO, RJ
PA RUA SANTA CLARA 292, RIO DE JANEIRO, RJ, CEP 22401-01, BRAZIL
SN 0021-7557
EI 1678-4782
J9 J PEDIAT-BRAZIL
JI J. Pediatr.
PD JUL-AUG
PY 2011
VL 87
IS 4
BP 350
EP 356
DI 10.2223/JPED.2115
PG 7
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA 816AW
UT WOS:000294572100013
PM 21842113
DA 2025-06-11
ER

PT J
AU Zivkovic, AM
   German, JB
   Sanyal, AJ
AF Zivkovic, Angela M.
   German, J. Bruce
   Sanyal, Arun J.
TI Comparative review of diets for the metabolic syndrome: implications for
   nonalcoholic fatty liver disease
SO AMERICAN JOURNAL OF CLINICAL NUTRITION
LA English
DT Review
DE nonalcoholic fatty liver disease; NAFLD; non-alcoholic steatohepatitis;
   NASH; diet; weight loss
ID DE-NOVO LIPOGENESIS; CORONARY-HEART-DISEASE; ENDOPLASMIC-RETICULUM
   STRESS; AMINO-ACID SUPPLEMENTATION; CONJUGATED LINOLEIC-ACID;
   MEDITERRANEAN-STYLE DIET; LOW-CARBOHYDRATE DIET; CARDIOVASCULAR-DISEASE;
   HEPATIC STEATOSIS; INSULIN-RESISTANCE
AB Nonalcoholic fatty liver disease (NAFLD) is a significant health problem and affects 70 million adults in the United States (30% of the adult population), and an estimated 20% of these individuals have the most severe form of NAFLD-nonalcoholic steatohepatitis (NASH). The mechanisms underlying disease development and progression are awaiting clarification. Insulin resistance and obesity-related inflammation, among other possible genetic, dietary, and lifestyle factors, are thought to play a key role. A program targeting gradual weight reduction and physical exercise continues to be the gold standard of treatment for all forms of NAFLD. Even though weight loss and dietary and lifestyle changes are recommended as primary treatment for fatty liver, little to no scientific evidence is available on diet and NAFLD. This article reviews the implications of current dietary approaches, including national guidelines and popular weight-loss diets, with a focus on determining the optimal diet to prescribe for NAFLD and NASH patients. The effects of macronutrient content (carbohydrate, fat, and protein ratios) and specific food components, such as soluble fiber, n- 3 fatty acids, and fructose, are discussed. The premises, effects, barriers, and issues related to current dietary guidelines and specific diets are discussed, and the question, "Will it work for the pathogenesis of NAFLD and NASH? ", is addressed.
C1 Virginia Commonwealth Univ, Dept Internal Med, Div Gastroenterol Hepatol & Nutr, Richmond, VA 23298 USA.
   Univ Calif Davis, Dept Food Sci & Technol, Davis, CA 95616 USA.
   Nestle Res Ctr, CH-1000 Lausanne, Switzerland.
C3 Virginia Commonwealth University; University of California System;
   University of California Davis; Nestle SA; Nestle Research Center
RP Sanyal, AJ (corresponding author), Virginia Commonwealth Univ, Dept Internal Med, Div Gastroenterol Hepatol & Nutr, PO Box 980341, Richmond, VA 23298 USA.
EM amzivkovic@ucdavis.edu; ajsanyal@mail2.vcu.edu
OI Zivkovic, Angela/0000-0002-2828-7862
FU PHS HHS [K24 02755-07] Funding Source: Medline
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   2003, AMERICAONTHEMOVE
NR 195
TC 305
Z9 330
U1 1
U2 60
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0002-9165
EI 1938-3207
J9 AM J CLIN NUTR
JI Am. J. Clin. Nutr.
PD AUG
PY 2007
VL 86
IS 2
BP 285
EP 300
DI 10.1093/ajcn/86.2.285
PG 16
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 198LN
UT WOS:000248629700004
PM 17684197
OA Bronze
DA 2025-06-11
ER

PT J
AU Otabe, S
   Yuan, XH
   Fukutani, T
   Wada, N
   Hashinaga, T
   Nakayama, H
   Hirota, N
   Kojima, M
   Yamada, K
AF Otabe, Shuichi
   Yuan, Xiaohong
   Fukutani, Tomoka
   Wada, Nobuhiko
   Hashinaga, Toshihiko
   Nakayama, Hitomi
   Hirota, Naotoshi
   Kojima, Masayasu
   Yamada, Kentaro
TI Overexpression of human adiponectin in transgenic mice results in
   suppression of fat accumulation and prevention of premature death by
   high-calorie diet
SO AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
LA English
DT Article
DE adipocyte; macrophage; life span; 8-hyroxy-2-deoxyguanosine
ID OXIDATIVE DNA-DAMAGE; BRAIN NATRIURETIC PEPTIDE; ADIPOSE-SPECIFIC
   PROTEIN; INSULIN-RESISTANCE; GLUCOSE-METABOLISM; FREE-RADICALS;
   WEIGHT-LOSS; OBESITY; DISEASE; STRESS
AB Adiponectin, a physiologically active polypeptide secreted by adipocytes, shows insulm- sensitizing, anti-inflammatory, and antiatherogenic, properties in rodents and humans. To assess the effects of chronic hyperadiponectinerma on metabolic phenotypes, we established three lines of transgenic mice expressing human adiponectin in the liver. When maintained on a high-fat/high-sucrose diet, mice of two lines that had persistent hyperadiponectinerma exhibited significantly decreased weight gain associated with less fat accumulation and smaller adipocytes in both visceral and subcutaneous adipose tissues. Macrophage infiltration in adipose tissue was markedly suppressed in the transgenic mice. Expression levels of adiponectin receptors were not altered in skeletal muscle or liver. Circulating levels of endogenous adiponectin were elevated, whereas fasting glucose, insulin, and leptin levels were reduced compared with control mice. In the hyperadiponectinemic mice daily food intake was not altered, but oxygen consumption was significantly greater, suggesting increased energy expenditure. Moreover, high-calorie diet-induced premature death was almost completely prevented in the hyperadiponectinemic, mice in association with attenuated oxidative DNA damage. The transgenic, mice also showed longer life span on a conventional low-fat chow. In conclusion, transgenic expression of human adiponectin blocked the excessive fat accumulation and reduced the morbidity and mortality in mice fed a high-calorie diet. These observations may provide new insights into the prevention and therapy of metabolic syndrome in humans.
C1 Kurume Univ, Sch Med, Dept Med, Div Endocrinol & Metab, Kurume, Fukuoka 8300011, Japan.
   Kurume Univ, Inst Life Sci, Dept Mol Genet, Kurume, Fukuoka 8300011, Japan.
C3 Kurume University; Kurume University
RP Yamada, K (corresponding author), Kurume Univ, Sch Med, Dept Med, Div Endocrinol & Metab, 67 Asahimachi, Kurume, Fukuoka 8300011, Japan.
EM yamada@med.kurume-u.ac.jp
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NR 44
TC 107
Z9 116
U1 0
U2 6
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0193-1849
J9 AM J PHYSIOL-ENDOC M
JI Am. J. Physiol.-Endocrinol. Metab.
PD JUL
PY 2007
VL 293
IS 1
BP E210
EP E218
DI 10.1152/ajpendo.00645.2006
PG 9
WC Endocrinology & Metabolism; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Physiology
GA 190OJ
UT WOS:000248068200027
PM 17389708
DA 2025-06-11
ER

PT J
AU de Carvalho, EEV
   Santi, GL
   Crescêncio, JC
   de Oliveira, LFL
   dos Reis, DCC
   Figueiredo, AB
   Pintya, AO
   Lima, MO
   Gallo, L
   Marin-Neto, JA
   Simoes, MV
AF Vieira de Carvalho, Eduardo Elias
   Santi, Giovani Luiz
   Crescencio, Julio Cesar
   Lemos de Oliveira, Luciano Fonseca
   Costa dos Reis, Daniela Caetano
   Figueiredo, Alexandre Baldini
   Pintya, Antonio Osvaldo
   Lima-Filho, Moyses Oliveira
   Gallo-Junior, Lourenco
   Marin-Neto, Jose Antonio
   Simoes, Marcus Vinicius
TI Pilot study testing the effect of physical training over the myocardial
   perfusion and quality of life in patients with primary microvascular
   angina
SO JOURNAL OF NUCLEAR CARDIOLOGY
LA English
DT Article
DE Coronary microvascular dysfunction; myocardial perfusion; angina;
   physical training
ID CARDIAC SYNDROME-X; CORONARY-ARTERY-DISEASE; CARDIOVASCULAR
   MAGNETIC-RESONANCE; ISCHEMIA-SYNDROME-EVALUATION; LEFT-VENTRICULAR
   FUNCTION; CHEST-PAIN; EXERCISE; DYSFUNCTION; ANGIOGRAMS; WOMEN
AB Primary microvascular angina (PMA) is a common clinical condition associated to negative impact on quality of life (QOL) and reduced physical capacity. This study aimed at evaluating the effects of aerobic physical training (APT) on myocardial perfusion, physical capacity, and QOL in patients with PMA.
   We investigated 12 patients (53.8 +/- A 9.7 years old; 7 women) with PMA, characterized by angina, angiographycally normal coronary arteries, and reversible perfusion defects (RPDs) detected on Tc-99m-sestamibi-SPECT myocardial perfusion scintigraphy (MPS). At baseline and after 4 month of APT, the patients underwent MPS, cardiopulmonary test, and QOL questionnaire. Stress-rest MPS images were visually analyzed by attributing semi-quantitative scores (0 = normal; 4 = absent uptake), using a 17-segment left ventricular model. Summed stress, rest, and difference scores (SDS) were calculated.
   In comparison to the baseline, in the post-training we observed a significant increase in peak-VO2 (19.4 +/- A 4.8 and 22.1 +/- A 6.2 mL center dot kg(-1)center dot minute(-1), respectively, P = .01), reduction of SDS (10.1 +/- A 8.8 and 2.8 +/- A 4.9, P = .008), and improvement in QOL scores.
   Physical training in patients with PMA is associated with reduction of myocardial perfusion abnormalities, increasing of physical capacity, and improvement in QOL. The findings of this hypothesis-generating study suggest that APT can be a valid therapeutic option for patients with PMA.
C1 [Vieira de Carvalho, Eduardo Elias; Santi, Giovani Luiz; Crescencio, Julio Cesar; Lemos de Oliveira, Luciano Fonseca; Costa dos Reis, Daniela Caetano; Figueiredo, Alexandre Baldini; Pintya, Antonio Osvaldo; Lima-Filho, Moyses Oliveira; Gallo-Junior, Lourenco; Marin-Neto, Jose Antonio; Simoes, Marcus Vinicius] Hosp Clin Sao Paulo, Fac Med Ribeirao Preto, Dept Internal Med, Div Cardiol, Sao Paulo, Brazil.
   [Simoes, Marcus Vinicius] Univ Sao Paulo, Med Sch Ribeirao Preto, Div Cardiol, Dept Internal Med, BR-14049 Ribeirao Preto, Brazil.
RP Simoes, MV (corresponding author), Univ Sao Paulo, Med Sch Ribeirao Preto, Div Cardiol, Dept Internal Med, BR-14049 Ribeirao Preto, Brazil.
EM msimoes@fmrp.usp.br
RI SIMOES, MARCUS/G-4898-2012; Marin-Neto, Jose/F-6099-2012; Carvalho,
   Eduardo/F-3525-2019; Crescencio, Julio/N-1905-2016; Oliveira, Luciano
   Fonseca Lemos de/D-1249-2016
OI Marin-Neto, Jose Antonio/0000-0002-8651-8833; Oliveira, Luciano Fonseca
   Lemos de/0000-0003-3455-2463
FU Fundacao de Apoio a Pesquisa do Estado de Sao Paulo (FAPESP)
   [2008/04140-3]
FX This study was supported by a research grant from Fundacao de Apoio a
   Pesquisa do Estado de Sao Paulo (FAPESP, No. 2008/04140-3).
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U1 0
U2 5
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1071-3581
EI 1532-6551
J9 J NUCL CARDIOL
JI J. Nucl. Cardiol.
PD FEB
PY 2015
VL 22
IS 1
BP 130
EP 137
DI 10.1007/s12350-014-9949-6
PG 8
WC Cardiac & Cardiovascular Systems; Radiology, Nuclear Medicine & Medical
   Imaging
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Radiology, Nuclear Medicine &
   Medical Imaging
GA CA3EZ
UT WOS:000348790400019
PM 25080872
DA 2025-06-11
ER

PT J
AU Chrysant, SG
   Chrysant, GS
AF Chrysant, Steven G.
   Chrysant, George S.
TI Olive Oil Consumption and Cardiovascular Protection: Mechanism of Action
SO CARDIOLOGY IN REVIEW
LA English
DT Review
DE monounsaturated fatty acids; olive oil; cardiovascular disease;
   hypertension; diabetes mellitus
ID MEDITERRANEAN DIET RICH; CORONARY-HEART-DISEASE; ENDOTHELIAL FUNCTION;
   OXIDATIVE STRESS; MYOCARDIAL-INFARCTION; METABOLIC SYNDROME;
   CLINICAL-TRIAL; BLOOD-PRESSURE; FATTY-ACIDS; RISK
AB Cardiovascular diseases (CVDs) are still the leading cause of death and disability worldwide, and they could be prevented by a diet modification and a healthy lifestyle. Dietary modifications include a reduction in the consumption of saturated fatty acids and replacing them with mono or polyunsaturated fatty acids. Olive oil is a monounsaturated fatty acid and its increased consumption has been associated with a significant reduction of CVDs. Its significant cardiovascular benefits have been attributed to its high content of vitamin E, polyphenols, and other ingredients that possess significant anti-inflammatory and antioxidant properties. Several prospective and epidemiological studies have reported an inverse association between olive oil consumption and the incidence of CVD, hypertension, and type 2 diabetes mellitus. Also, a seminal study demonstrated that the use of a Mediterranean diet, which is rich in olive oil, fruits, vegetables, and fish, and low in red meat, was associated with significant reductions in CVD and mortality. However, despite its proven cardiovascular benefits, olive oil is scarcely used in the United States and other Western countries. To determine the current use of olive oil in the United States and other Western countries, a Medline search of the English literature between 2012 and January 2022 was conducted, and 36 pertinent articles were selected. The data from these articles, together with collateral literature, will be discussed in this concise review.
C1 [Chrysant, Steven G.] Univ Oklahoma, Hlth Sci Ctr, Dept Cardiol, Oklahoma City, OK USA.
   [Chrysant, George S.] INTEGRIS Baptist Med Ctr, Oklahoma City, OK USA.
   [Chrysant, Steven G.] 5700 Mistletoe Court, Oklahoma City, OK 73142 USA.
C3 University of Oklahoma System; University of Oklahoma Health Sciences
   Center
RP Chrysant, SG (corresponding author), 5700 Mistletoe Court, Oklahoma City, OK 73142 USA.
EM schrysant@yahoo.com
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PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1061-5377
EI 1538-4683
J9 CARDIOL REV
JI Cardiol. Rev.
PD JAN-FEB
PY 2024
VL 32
IS 1
BP 57
EP 61
DI 10.1097/CRD.0000000000000449
PG 5
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA Z8KN6
UT WOS:001114509300003
PM 35290249
DA 2025-06-11
ER

PT J
AU Fang, XY
   Gao, CY
   Wu, WF
   Hu, XX
   Shao, MM
   Zhou, C
   Cai, RL
   Fang, J
   Li, Y
   Xu, Y
   Zhang, XR
AF Fang, Xinyu
   Gao, Chunying
   Wu, Weifeng
   Hu, Xiuxiu
   Shao, Miaomiao
   Zhou, Chou
   Cai, Renliang
   Fang, Jin
   Li, Yi
   Xu, Yue
   Zhang, Xiangrong
TI The role of the gut microbiome in weight-gain in schizophrenia patients
   treated with atypical antipsychotics: Evidence based on altered
   composition and function in a cross-sectional study
SO PSYCHIATRY RESEARCH
LA English
DT Article
DE Atypical antipsychotics; Weight-gain; Gut microbiome; 16S rRNA
   sequencing; Schizophrenia
ID METABOLIC SYNDROME; OBESE; DYSFUNCTION; IMPROVEMENT; PREVALENCE;
   OLANZAPINE; STRESS
AB Objectives: We aimed to explore the interconnection between the weight-gain in schizophrenia patients with atypical antipsychotic treatment and gut microbiome. Methods: This study employed a cross-sectional design, encompassing a total of 88 schizophrenia patients with long-term atypical antipsychotic treatment. The 16S rRNA gene sequencing was used to identify gut microbiome contents. Results: No significant differences in alpha diversity between normal-weight and overweight schizophrenia treated with atypical antipsychotics. The beta diversity analysis showed that overweight patients clustered tightly while normal-weight patients clustered widely. For taxonomic composition, overweight patients had a lower relative abundance in Porphyromonadaceae at family level and Butyrivibrio at genus level, but higher relative abundance in Ruminococcus2 and Clostridium_XIVa at genus level than normal-weight patients. Function prediction revelated that four pathways (including Cell cycle, Non-homologous end-joining, Vibrio cholerae infection and Meiosis-yeast) were significantly different between groups. Correlation analysis indicated that Klebsiella, Butyrivibrio, Unassigned, Methanosphaera, Holdemania, Anaerotruncus were negatively, while Veillonella was positively correlated with BMI in patients. Conclusion: Our findings offer evidence that perturbations in the gut microbiome composition, encompassing taxa such as Porphyromonadaceae, Butyrivibrio, Ruminococcus2, and Clostridium_XIVa, in conjunction with distinct functional pathways including Cell cycle, Non-homologous end-joining, Vibrio cholerae infection, and Meiosisyeast, might contribute to the weight-gain in schizophrenia treated with atypical antipsychotics.
C1 [Fang, Xinyu; Gao, Chunying; Zhou, Chou; Cai, Renliang; Fang, Jin; Li, Yi; Xu, Yue; Zhang, Xiangrong] Nanjing Med Univ, Affiliated Brain Hosp, Dept Geriatr Psychiat, Nanjing, Peoples R China.
   [Gao, Chunying] Changzhou Dean Hosp, Dept Psychiat, Changzhou, Peoples R China.
   [Wu, Weifeng] Nanjing Univ Chinese Med, Hosp Nanjing 2, Dept Hepatol, Nanjing, Peoples R China.
   [Wu, Weifeng] Nanjing Publ Hlth & Med Ctr, Nanjing, Peoples R China.
   [Hu, Xiuxiu; Shao, Miaomiao] Jiangning Dist Second Peoples Hosp, Dept Psychiat, Nanjing, Peoples R China.
   [Zhang, Xiangrong] Xuzhou Med Univ, Affiliated Xuzhou Oriental Hosp, Xuzhou, Jiangsu, Peoples R China.
   [Li, Yi; Xu, Yue; Zhang, Xiangrong] Nanjing Med Univ, Affiliated Brain Hosp, Nanjing, Jiangsu, Peoples R China.
C3 Nanjing Medical University; Nanjing University of Chinese Medicine;
   Xuzhou Medical University; Nanjing Medical University
RP Li, Y; Xu, Y; Zhang, XR (corresponding author), Nanjing Med Univ, Affiliated Brain Hosp, Nanjing, Jiangsu, Peoples R China.
EM lear0271@163.com; tsuiycn@foxmail.com; drxrz@hotmail.com
RI WU, Weifeng/ABA-2342-2020; Fang, Xinyu/IYT-2547-2023
OI Fang, Xinyu/0000-0002-3503-7765
FU National Key Research and Development Program of China [2018YFC1314300,
   2016YFC1307002]; National Natural Science Foundation of China [81971255,
   81571314, 82101572]; Social Development Foundation of Jiangsu Province,
   China [BE2019610]; Jiangsu Provincial Medical Talent project
   [ZDRCA2016075]; Medical Science and Technology Development Foundation,
   Nanjing Department of Health [YKK20090]; Science and Technology
   Development Program of Nanjing Medical University [NMUB2019107]
FX This study was supported by the National Key Research and Development
   Program of China (No. 2018YFC1314300 and 2016YFC1307002) , the National
   Natural Science Foundation of China (81971255, 81571314 and 82101572) ,
   Social Development Foundation of Jiangsu Province, China (No. BE2019610)
   , Jiangsu Provincial Medical Talent project (ZDRCA2016075) , the Key
   Project supported by Medical Science and Technology Development
   Foundation, Nanjing Department of Health (YKK20090) , and the Science
   and Technology Development Program of Nanjing Medical University
   (NMUB2019107) .
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PU ELSEVIER IRELAND LTD
PI CLARE
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SN 0165-1781
EI 1872-7123
J9 PSYCHIAT RES
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PY 2023
VL 328
AR 115463
DI 10.1016/j.psychres.2023.115463
EA SEP 2023
PG 9
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA T8NM7
UT WOS:001080496600001
PM 37717547
DA 2025-06-11
ER

PT J
AU Ivanov, DO
   Evsyukova, II
   Mironova, ES
   Polyakova, VO
   Kvetnoy, IM
   Nasyrov, RA
AF Ivanov, Dmitry O.
   Evsyukova, Inna I.
   Mironova, Ekaterina S.
   Polyakova, Victoria O.
   Kvetnoy, Igor M.
   Nasyrov, Ruslan A.
TI Maternal Melatonin Deficiency Leads to Endocrine Pathologies in Children
   in Early Ontogenesis
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE melatonin; endocrine pathology; children; early ontogenesis; family
   planning
ID ENDOPLASMIC-RETICULUM STRESS; CIRCADIAN CLOCK; METABOLIC SYNDROME;
   SUPRACHIASMATIC NUCLEUS; INSULIN-RESISTANCE; CHILDHOOD OBESITY;
   GENE-EXPRESSION; FETAL-GROWTH; EXTRAPINEAL MELATONIN; EPIGENETIC
   REGULATION
AB The review summarizes the results of experimental and clinical studies aimed at elucidating the causes and pathophysiological mechanisms of the development of endocrine pathology in children. The modern data on the role of epigenetic influences in the early ontogenesis of unfavorable factors that violate the patterns of the formation of regulatory mechanisms during periods of critical development of fetal organs and systems and contribute to the delayed development of pathological conditions are considered. The mechanisms of the participation of melatonin in the regulation of metabolic processes and the key role of maternal melatonin in the formation of the circadian system of regulation in the fetus and in the protection of the genetic program of its morphofunctional development during pregnancy complications are presented. Melatonin, by controlling DNA methylation and histone modification, prevents changes in gene expression that are directly related to the programming of endocrine pathology in offspring. Deficiency and absence of the circadian rhythm of maternal melatonin underlies violations of the genetic program for the development of hormonal and metabolic regulatory mechanisms of the functional systems of the child, which determines the programming and implementation of endocrine pathology in early ontogenesis, contributing to its development in later life. The significance of this factor in the pathophysiological mechanisms of endocrine disorders determines a new approach to risk assessment and timely prevention of offspring diseases even at the stage of family planning.
C1 [Ivanov, Dmitry O.; Polyakova, Victoria O.; Nasyrov, Ruslan A.] St Petersburg State Pediat Med Univ, Dept Neonatol, Litovskaya Ulitsa 2, St Petersburg 194100, Russia.
   [Evsyukova, Inna I.] Ott Res Inst Obstet Gynecol & Reproductol, Mendeleyevskaya Liniya 3, St Petersburg 199034, Russia.
   [Mironova, Ekaterina S.] St Petersburg Inst Bioregulat & Gerontol, Dynamo Ave 3, St Petersburg 197110, Russia.
   [Mironova, Ekaterina S.; Kvetnoy, Igor M.] St Petersburg Res Inst Phthisiopulmonol, Lygovsky Ave 2-4, St Petersburg 191036, Russia.
   [Kvetnoy, Igor M.] St Petersburg State Univ, Dept Pathol, Univ Embankment 7-9, St Petersburg 199034, Russia.
C3 Saint Petersburg State Pediatric Medical University; Russian Academy of
   Medical Sciences; Ott Institute of Obstetrics, Gynecology &
   Reproductology; St. Petersburg State Research Institute of
   Phthisiopulmonology; Saint Petersburg State University
RP Mironova, ES (corresponding author), St Petersburg Inst Bioregulat & Gerontol, Dynamo Ave 3, St Petersburg 197110, Russia.; Mironova, ES (corresponding author), St Petersburg Res Inst Phthisiopulmonol, Lygovsky Ave 2-4, St Petersburg 191036, Russia.
EM doivanov@yandex.ru; eevs@yandex.ru; katrine1994@mail.ru;
   doivanov@yandex.ru; igor.kvetnoy@yandex.ru; rrmd99@mail.ru
RI Mironova, Ekaterina/AEX-7817-2022; Ivanov, Dmitry/D-6763-2018
OI Mironova, Ekaterina/0000-0001-8134-5104; Polyakova,
   Victoria/0000-0001-8682-9909
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NR 195
TC 8
Z9 8
U1 0
U2 5
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD FEB
PY 2021
VL 22
IS 4
AR 2058
DI 10.3390/ijms22042058
PG 17
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA QP4LV
UT WOS:000623808700001
PM 33669686
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Song, JY
   Shen, TC
   Hou, YC
   Chang, JF
   Lu, CL
   Liu, WC
   Chen, PJ
   Chen, BH
   Zheng, CM
   Lu, KC
AF Song, Jenn-Yeu
   Shen, Ta-Chung
   Hou, Yi-Chou
   Chang, Jia-Feng
   Lu, Chien-Lin
   Liu, Wen-Chih
   Chen, Po-Jui
   Chen, Bo-Hau
   Zheng, Cai-Mei
   Lu, Kuo-Cheng
TI Influence of Resveratrol on the Cardiovascular Health Effects of Chronic
   Kidney Disease
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE cardiovascular disease; chronic kidney disease; indoxyl sulfate;
   microbiota; p-cresol sulfate; resveratrol; trimethylamine-N-oxide
ID HIGH-FAT DIET; ACTIVATED PROTEIN-KINASE; GUT MICROBIOTA; NITRIC-OXIDE;
   ENDOTHELIAL DYSFUNCTION; INDOXYL SULFATE; RED WINE; OXIDATIVE STRESS;
   MITOCHONDRIAL BIOGENESIS; INSULIN-RESISTANCE
AB Cardiovascular disease (CVD) is closely related to chronic kidney disease (CKD), and patients with CKD have a high risk of CVD-related mortality. Traditional CVD risk factors cannot account for the higher cardiovascular risk of patients with CKD, and standard CVD interventions cannot reduce the mortality rates among patients with CKD. Nontraditional factors related to mineral and vitamin-D metabolic disorders provide some explanation for the increased CVD risk. Non-dialyzable toxins, indoxyl sulfate (IS) andp-cresol sulfate (PCS)-produced in the liver by colonic microorganisms-cause kidney and vascular dysfunction. Plasma trimethylamine-N-oxide (TMAO)-a gut microbe-dependent metabolite of dietary L-carnitine and choline-is elevated in CKD and related to vascular disease, resulting in poorer long-term survival. Therefore, the modulation of colonic flora can improve prospects for patients with CKD. Managing metabolic syndrome, anemia, and abnormal mineral metabolism is recommended for the prevention of CVD in patients with CKD. Considering nontraditional risk factors, the use of resveratrol (RSV), a nutraceutical, can be helpful for patients with CVD and CKD. This paper discusses the beneficial effects of RSV on biologic, pathophysiological and clinical responses, including improvements in intestinal epithelial integrity, modulation of the intestinal microbiota and reduction in hepatic synthesis of IS, PCS and TMAO in patients with CVD and CKD.
C1 [Song, Jenn-Yeu; Shen, Ta-Chung] Taipei Tzu Chi Hosp, Buddhist Tzu Chi Med Fdn, Dept Surg, Div Cardiovasc Surg, New Taipei 231, Taiwan.
   [Song, Jenn-Yeu; Shen, Ta-Chung] Tzu Chi Univ, Sch Med, Hualien 970, Taiwan.
   [Hou, Yi-Chou] Fu Jen Catholic Univ, Cardinal Tien Hosp, Sch Med, Div Nephrol,Dept Med, New Taipei 234, Taiwan.
   [Chang, Jia-Feng] En Chu Kong Hosp, Dept Internal Med, Div Nephrol, New Taipei 237, Taiwan.
   [Lu, Chien-Lin] Fu Jen Catholic Univ, Fu Jen Catholic Univ Hosp, Sch Med, Div Nephrol,Dept Med, New Taipei 242, Taiwan.
   [Liu, Wen-Chih] Minist Hlth & Welf, Dept Med, Div Nephrol, Taipei Hosp, New Taipei 242, Taiwan.
   [Chen, Po-Jui; Chen, Bo-Hau] Taoyuan Armed Forces Gen Hosp, Dept Pediat, Taoyuan 325, Taiwan.
   [Zheng, Cai-Mei] Taipei Med Univ, Res Ctr Urol & Kidney, Taipei 110, Taiwan.
   [Zheng, Cai-Mei] Taipei Med Univ, Dept Internal Med, Div Nephrol, Shuang Ho Hosp, New Taipei 235, Taiwan.
   [Zheng, Cai-Mei] Taipei Med Univ, Coll Med, Sch Med, Div Nephrol,Dept Internal Med, Taipei 110, Taiwan.
   [Lu, Kuo-Cheng] Taipei Tzu Chi Hosp, Buddhist Tzu Chi Med Fdn, Dept Med, Div Nephrol, New Taipei 231, Taiwan.
C3 Buddhist Tzu Chi General Hospital; Taipei Tzu Chi Hospital; Tzu Chi
   University; Fu Jen Catholic University; Fu Jen Catholic University; Fu
   Jen Catholic University Hospital; Taipei Medical University; Taipei
   Medical University; Shuang Ho Hospital; Taipei Medical University;
   Buddhist Tzu Chi General Hospital; Taipei Tzu Chi Hospital
RP Zheng, CM (corresponding author), Taipei Med Univ, Res Ctr Urol & Kidney, Taipei 110, Taiwan.; Zheng, CM (corresponding author), Taipei Med Univ, Dept Internal Med, Div Nephrol, Shuang Ho Hosp, New Taipei 235, Taiwan.; Zheng, CM (corresponding author), Taipei Med Univ, Coll Med, Sch Med, Div Nephrol,Dept Internal Med, Taipei 110, Taiwan.
EM doc98017@gmail.com; frederick_shen@hotmail.com; athletics910@gmail.com;
   cjf6699@gmail.com; janlin0123@gmail.com; wayneliu55@gmail.com;
   mythnobody0221@gmail.com; dreamvenice@hotmail.com; 11044@s.tmu.edu.tw;
   kuochenglu@gmail.com
RI Chang, Jia-Feng/AAW-1326-2020
OI Chang, Jia-Feng/0000-0002-9903-7473; Cai-mei, Zheng/0000-0003-0370-3951
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NR 126
TC 19
Z9 21
U1 0
U2 15
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD SEP
PY 2020
VL 21
IS 17
AR 6294
DI 10.3390/ijms21176294
PG 16
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA NO8WD
UT WOS:000569767200001
PM 32878067
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Cicek, M
   Tumer, MK
   Unsal, V
AF Cicek, Mustafa
   Tumer, Mehmet Kemal
   Unsal, Velid
TI A study of chewing muscles: Age-related changes in type I collagen and
   matrix metalloproteinase-2 expression
SO ARCHIVES OF ORAL BIOLOGY
LA English
DT Article
DE Masticator muscles; Type I collagen; Matrix metalloproteinases;
   Stomatognathic system; Aging
ID OXIDATION PROTEIN PRODUCTS; MASSETER MUSCLE; MASTICATORY MUSCLES;
   METABOLIC SYNDROME; NITRIC-OXIDE; STRESS; EXERCISE; ANTIOXIDANTS;
   ELEMENTS; PATHWAYS
AB Objective: In this study, the aim was to investigate the biochemical, physiological and histological changes that occur in masticatory muscles of the masticatory system with aging.
   Design: In this study, 14 BALB/c mice were used. Animals were divided into two equal groups of seven. Group I was organized as the group of young animals (n = 7) and Group II as the group of adult animals (n = 7). After routine histological follow-up was performed, the tissues were embedded in paraffin. 4-5 im thick cross-sections were taken from paraffin-embedded tissues and they were stained with Haemotoxylin and Eosin Type I collagen and Matrix metalloproteinase-2 (MMP-2) immunohistochemically.
   Results: It was observed that there was a decrease and shrinking in blood vessels due to aging. In young mice, Type I collagen and MMP-2 immunoreactivity in the masseter muscle tissue showed low staining, while Type I collagen and MMP-2 immunoreactivity in the temporal muscle tissue showed moderate staining. Type I collagen and MMP-2 immunoreactivity were significantly higher in the masseter and temporal muscles of elderly mice (p = 0.001). In the H-score evaluation, MMP-2 immune reactivity was significantly lower in young mice than in older mice (p = 0.001).
   Conclusion: It was determined that severe pain complications and functional losses are likely to occur with the increase of degeneration due to aging of masticator muscles.
C1 [Cicek, Mustafa] Kahramanmaras Sutcu Imam Univ, Fac Med, Dept Anat, Kahramanmaras, Turkey.
   [Tumer, Mehmet Kemal] Gaziosmanpasa Univ, Fac Dent, Dept Oral & Maxillofacial Surg, Tokat, Turkey.
   [Tumer, Mehmet Kemal] Gaziosmanpasa Univ, Fac Med, Dept Med Biol, Tokat, Turkey.
   [Unsal, Velid] Mardin Artuklu Univ, Fac Hlth Sci, Mardin, Turkey.
   [Unsal, Velid] Mardin Artuklu Univ, Cent Res Lab, Mardin, Turkey.
C3 Kahramanmaras Sutcu Imam University; Tokat Gaziosmanpasa University;
   Tokat Gaziosmanpasa University; Mardin Artuklu University; Mardin
   Artuklu University
RP Unsal, V (corresponding author), Mardin Artuklu Univ, Fac Hlth Sci, Mardin, Turkey.; Unsal, V (corresponding author), Mardin Artuklu Univ, Cent Res Lab, Mardin, Turkey.
EM mustafacicek_GOP@hotmail.com; dr_kemaltumer@yahoo.com;
   velidunsal@gmail.com
RI Tumer, Mehmet/R-3428-2019; ÇİÇEK, Mustafa/ABT-6574-2022; UNSAL,
   Velid/A-6189-2019
OI UNSAL, Velid/0000-0003-1415-0563; Cicek, Mustafa/0000-0001-8925-0230
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NR 66
TC 3
Z9 5
U1 0
U2 6
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0003-9969
EI 1879-1506
J9 ARCH ORAL BIOL
JI Arch. Oral Biol.
PD JAN
PY 2020
VL 109
AR 104583
DI 10.1016/j.archoralbio.2019.104583
PG 10
WC Dentistry, Oral Surgery & Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dentistry, Oral Surgery & Medicine
GA LA0NA
UT WOS:000523652700004
PM 31706109
DA 2025-06-11
ER

PT J
AU Godos, J
   Vitale, M
   Micek, A
   Ray, S
   Martini, D
   Del Rio, D
   Riccardi, G
   Galvano, F
   Grosso, G
AF Godos, Justyna
   Vitale, Marilena
   Micek, Agnieszka
   Ray, Sumantra
   Martini, Daniela
   Del Rio, Daniele
   Riccardi, Gabriele
   Galvano, Fabio
   Grosso, Giuseppe
TI Dietary Polyphenol Intake, Blood Pressure, and Hypertension: A
   Systematic Review and Meta-Analysis of Observational Studies
SO ANTIOXIDANTS
LA English
DT Review
DE flavonoid; anthocyanin; flavones; hypertension; blood pressure;
   meta-analysis; cohort
ID MAJOR FOOD SOURCES; HIGH CARDIOVASCULAR RISK; NITRIC-OXIDE;
   MEDITERRANEAN DIET; OXIDATIVE STRESS; ENDOTHELIAL DYSFUNCTION;
   POSTMENOPAUSAL WOMEN; METABOLIC SYNDROME; VASCULAR FUNCTION; FLAVONOID
   INTAKE
AB Background: Dietary polyphenols, including flavonoids, have been the focus of major recent attentions due to their wide content in a variety of foods commonly consumed and the findings from numerous studies showing evidence of an association with positive outcomes on human health. Methods: A systematic search using electronic databases PubMed and EMBASE was performed to retrieve English language studies published from the earliest indexing year of each database to April 2019, reporting on the association between dietary flavonoids intake and hypertension. Results: The search strategy resulted in the final selection of 20 studies including 15 cross-sectional investigations and 7 prospective cohorts (1 study reported on 3 prospective cohorts). 5 prospective cohorts, comprising 200,256 individuals and 45,732 cases of hypertension were included in the quantitative analysis. Analysis by extreme quantiles of intake of flavonoid showed a non-significant association with decreased risk of hypertension (RR (risk ratio): 0.96, 95% CI (confidence interval): 0.89, 1.03). Taking into consideration individual flavonoid subclasses, dietary anthocyanins intake was associated with 8% reduction in risk of hypertension, when comparing highest vs. lowest exposure (RR: 0.92, 95% CI: 0.88, 0.97). Conclusions: Further studies are needed to strengthen the retrieved association between anthocyanins consumption and decreased risk of hypertension and clarify whether total flavonoids or rather individual subclasses may exert beneficial effects on blood pressure.
C1 [Godos, Justyna; Galvano, Fabio; Grosso, Giuseppe] Univ Catania, Dept Biomed & Biotechnol Sci, I-95123 Catania, Italy.
   [Godos, Justyna; Ray, Sumantra; Del Rio, Daniele; Grosso, Giuseppe] St Johns Innovat Ctr, NNEdPro Global Ctr Nutr & Hlth, Cambridge CB4 0WS, England.
   [Vitale, Marilena; Riccardi, Gabriele] Univ Naples Federico II, Dept Clin Med & Surg, I-80131 Naples, Italy.
   [Micek, Agnieszka] Jagiellonian Univ, Fac Hlth Sci, Dept Nursing Management & Epidemiol Nursing, Med Coll, PL-31501 Krakow, Poland.
   [Ray, Sumantra] Univ Cambridge, Wolfson Coll, Cambridge CB3 9BB, England.
   [Ray, Sumantra] Ulster Univ, Nutr Innovat Ctr Food & Hlth, Coleraine BT52 1SA, Londonderry, North Ireland.
   [Ray, Sumantra] MRC, Human Nutr Res Unit, Cambridge CB1 9NL, England.
   [Martini, Daniela; Del Rio, Daniele] Univ Parma, Dept Vet Sci, Lab Phytochem Physiol, I-43126 Parma, Italy.
C3 University of Catania; St Johns Innovation Centre - UK; University of
   Naples Federico II; Jagiellonian University; Collegium Medicum
   Jagiellonian University; University of Cambridge; Ulster University; UK
   Research & Innovation (UKRI); Medical Research Council UK (MRC); MRC
   Human Nutrition Research; University of Parma
RP Grosso, G (corresponding author), Univ Catania, Dept Biomed & Biotechnol Sci, I-95123 Catania, Italy.; Grosso, G (corresponding author), St Johns Innovat Ctr, NNEdPro Global Ctr Nutr & Hlth, Cambridge CB4 0WS, England.
EM justyna.godos@student.uj.edu.pl; marilena.vitale@yahoo.it;
   agnieszka.micek@uj.edu.pl; s.ray@nnedpro.org.uk;
   daniela.martini@unipr.it; daniele.delrio@unipr.it; riccardi@unina.it;
   fgalvano@unict.it; giuseppe.grosso@studium.unict.it
RI Godos, Justyna/AAC-1302-2019; Galvano, Fabio/JSL-7451-2023; Martini,
   Daniela/S-2499-2019; Micek, Agnieszka/AAC-4838-2019; Vitale,
   Marilena/J-1457-2014; Del Rio, Daniele/E-8696-2010; martini,
   daniela/D-6241-2015; Galvano, Fabio/F-8122-2010; Grosso,
   Giuseppe/K-6730-2016
OI Godos, Justyna/0000-0002-5809-5706; Vitale,
   Marilena/0000-0001-9951-4674; Del Rio, Daniele/0000-0001-5394-1259;
   martini, daniela/0000-0001-8298-926X; Galvano,
   Fabio/0000-0003-0644-0755; Micek, Agnieszka/0000-0001-8557-1774;
   Gregori, Giovanna/0000-0002-3566-4363; Grosso,
   Giuseppe/0000-0003-3930-5285
FU BBSRC [BB/P028225/1] Funding Source: UKRI
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NR 88
TC 108
Z9 111
U1 1
U2 18
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD JUN
PY 2019
VL 8
IS 6
DI 10.3390/antiox8060152
PG 21
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA II6FJ
UT WOS:000475288200004
PM 31159186
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Shephard, RJ
AF Shephard, Roy J.
TI Cancers of the Esophagus and Stomach: Potential Mechanisms Behind the
   Beneficial Influence of Physical Activity
SO CLINICAL JOURNAL OF SPORT MEDICINE
LA English
DT Article
DE gastric ulcer; gastroesophageal reflux; Helicobacter pylori infection;
   immune function; metabolic syndrome; obesity; oxidant stress
ID SQUAMOUS-CELL CARCINOMA; PEPTIC-ULCER DISEASE; POPULATION-BASED COHORT;
   BODY-MASS INDEX; GASTRIC-CANCER; RISK-FACTORS; LIFE-STYLE;
   GASTROESOPHAGEAL-REFLUX; GASTROINTESTINAL-TRACT; EPIDEMIOLOGIC EVIDENCE
AB Objective: To compare findings from several recent meta-analyses showing a reduced risk of gastric and esophageal cancers in physically active individuals, to assess the magnitude of this benefit, and to seek information on potential underlying mechanisms.
   Data Sources: A comprehensive search of Ovid/Medline from 1996 to February 2016, using the terms physical activity or exercise or training and esophageal or gastric cancer, and supplementing the articles identified by material from references lists and personal files.
   Main Results: Moderate-to-vigorous physical activity is associated with a 20% to 30% reduction in the risk of gastroesophageal adenocarcinomas, with a significant dose/response relationship. Benefit is greater in women than in men, and greater for noncardia than for cardia or esophageal tumors. Mechanisms could include a reduction of visceral fat (with a lesser production of cancer promoting hormones and reduced gastroesophageal reflux) and/or a lesser likelihood of smoking and excessive alcohol consumption. Physical activity does not protect against Helicobacter pylori infections or gastric ulceration, but mechanisms related to the impact of exercise on immune function, antioxidant mechanisms, and gastroesophageal reflux remain to be explored.
   Conclusions: Regular, moderate-to-vigorous physical activity is associated with a clinically significant reduction in the risk of gastroesophageal adenocarcinomas, but mechanisms are as yet unclear, and a causal relationship remains to be proven.
C1 [Shephard, Roy J.] Univ Toronto, Fac Kinesiol & Phys Educ, Toronto, ON, Canada.
C3 University of Toronto
RP Shephard, RJ (corresponding author), POB 521, Brackendale, BC V0N 1H0, Canada.
EM royjshep@shaw.ca
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NR 81
TC 3
Z9 4
U1 1
U2 8
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1050-642X
EI 1536-3724
J9 CLIN J SPORT MED
JI Clin. J. Sport Med.
PD JUL
PY 2017
VL 27
IS 4
BP 415
EP 421
DI 10.1097/JSM.0000000000000353
PG 7
WC Orthopedics; Physiology; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Physiology; Sport Sciences
GA EZ4EA
UT WOS:000404663800018
PM 27428674
DA 2025-06-11
ER

PT J
AU Yu, YH
   Liao, PR
   Guo, CJ
   Chen, CH
   Mochly-Rosen, D
   Chuang, LM
AF Yu, Yu-Hsiang
   Liao, Pei-Ru
   Guo, Chien-Jung
   Chen, Che-Hong
   Mochly-Rosen, Daria
   Chuang, Lee-Ming
TI PKC-ALDH2 Pathway Plays a Novel Role in Adipocyte Differentiation
SO PLOS ONE
LA English
DT Article
ID ALDEHYDE DEHYDROGENASE 2; CARDIAC PROTECTION; METABOLIC SYNDROME;
   OXIDATIVE STRESS; PPAR-GAMMA; PROTEIN; OBESITY; CARBONYLATION;
   ACTIVATION; EXPRESSION
AB The ALDH2 gene encodes the mitochondrial aldehyde dehydrogenase 2 (ALDH2), a critical enzyme involved in ethanol clearance through acetaldehyde metabolism. ALDH2 also catalyzes the metabolism of other bioreactive aldehydes, including propionaldehyde, butyraldehyde, and 4-hydroxykenals (4-HNE). Increased levels of 4-HNE in adipose tissue positively correlate with obesity and insulin resistance. However, it remains unclear whether ALDH2 is involved in regulation of adipocyte differentiation. Here, we found that ALDH2 protein levels were lower in white adipose tissue of high-fat diet-fed mice and ob/ob mice relative to lean mice. Knockdown of ALDH2 expression in 3T3-L1 preadipocytes caused an increase in intracellular 4-HNE, thereby attenuated adipocyte differentiation. By contrast, an ALDH2 activator, Alda-1, significantly accelerated adipogenesis, which was accompanied by an increase in adipogenic gene expression. Consistently, adipogenesis was reduced when protein kinase C epsilon (PKC epsilon), an ALDH2 phosphorylating activator, was silenced in 3T3-L1 preadipocytes, whereas treatment with a PKCe agonist in 3T3-L1 preadipocytes enhanced adipogenesis. Whole-genome microarray profiling of Alda-1-treated cells demonstrated several upregulated transcripts encoding proteins involved in metabolism and the majority of these transcripts are for proteins involved in PPAR signaling pathways. Furthermore, PKC epsilon-ALDH2 interaction alleviates 4-HNE induced aberrant PPAR. regulation on adipogenesis. Taken together, these results demonstrate that ALDH2 activation enhances adipogenesis and signaling pathways involving PPAR gamma. Thus, activation of PKC epsilon-ALDH2 regulatory axis may be a therapeutic target for treating obesity and type 2 diabetes.
C1 [Yu, Yu-Hsiang] Natl Ilan Univ, Dept Biotechnol & Anim Sci, Ilan, Taiwan.
   [Liao, Pei-Ru; Chuang, Lee-Ming] Natl Taiwan Univ Hosp, Dept Internal Med, Taipei, Taiwan.
   [Guo, Chien-Jung; Chuang, Lee-Ming] Natl Taiwan Univ, Inst Mol Med, Coll Med, Taipei, Taiwan.
   [Chen, Che-Hong; Mochly-Rosen, Daria] Stanford Univ, Dept Chem & Syst Biol, Sch Med, Stanford, CA 94305 USA.
   [Chuang, Lee-Ming] Natl Taiwan Univ, Dept Internal Med, Coll Med, Taipei, Taiwan.
C3 National Ilan University; National Taiwan University; National Taiwan
   University Hospital; National Taiwan University; Stanford University;
   National Taiwan University
RP Chuang, LM (corresponding author), Natl Taiwan Univ Hosp, Dept Internal Med, Taipei, Taiwan.; Chuang, LM (corresponding author), Natl Taiwan Univ, Inst Mol Med, Coll Med, Taipei, Taiwan.; Chuang, LM (corresponding author), Natl Taiwan Univ, Dept Internal Med, Coll Med, Taipei, Taiwan.
EM leeming@ntu.edu.tw
RI Chen, Michelle/N-9056-2013; Chuang, Lee-Ming/AAF-3324-2019; Yu,
   Yu-Hsiang/J-4424-2019
OI Mochly-Rosen, Daria/0000-0002-6691-8733; CHUANG,
   LEE-MING/0000-0003-0978-2662; Yu, Yu-Hsiang/0000-0001-9629-8478
FU Ministry of Science and Technology in Taiwan [MOST
   101-2314-B-002-158-MY3]; Ministry of Science and Technology in the US
   [NIAAA11147]
FX This work was supported by Ministry of Science and Technology MOST
   101-2314-B-002-158-MY3 to LMC in Taiwan and NIAAA11147 to DMR in the US.
   The funders had no role in study design, data collection and analysis,
   decision to publish, or preparation of the manuscript.
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Z9 25
U1 2
U2 13
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD AUG 30
PY 2016
VL 11
IS 8
AR e0161993
DI 10.1371/journal.pone.0161993
PG 17
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA DV4EE
UT WOS:000382877200052
PM 27575855
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Talarico, C
   Dattilo, V
   D'Antona, L
   Menniti, M
   Bianco, C
   Ortuso, F
   Alcaro, S
   Schenone, S
   Perrotti, N
   Amato, R
AF Talarico, Cristina
   Dattilo, Vincenzo
   D'Antona, Lucia
   Menniti, Miranda
   Bianco, Cataldo
   Ortuso, Francesco
   Alcaro, Stefano
   Schenone, Silvia
   Perrotti, Nicola
   Amato, Rosario
TI SGK1, the New Player in the Game of Resistance: Chemo-Radio Molecular
   Target and Strategy for Inhibition
SO CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
LA English
DT Review
DE SGK1; Chemo-resistance; Radio-resistance; RAN/RANBP1; MDM2; SGK1
   inhibitors
ID INDUCIBLE KINASE 1; HYDROPHOBIC MOTIF PHOSPHORYLATION; BREAST-CANCER
   CELLS; HEPATOCELLULAR-CARCINOMA; PROTEIN-KINASE; METABOLIC SYNDROME;
   PROSTATE-CANCER; SERUM; EXPRESSION; ACTIVATION
AB The serum- and glucocorticoid-regulated kinase (SGK) family consists of three members, SGK1, SGK2 and SGK3, all displaying serine/threonine kinase activity and sharing structural and functional similarities with the AKT family of kinases. SGK1 was originally described as a key enzyme in the hormonal regulation of several ion channels and pumps. Over time, growing and impressive evidence has been accumulated, linking SGK1 to the cell survival, de-differentiation, cell cycle control, regulation of caspases, response to chemical, mechanical and oxidative injury in cancer models as well as to the control of mitotic stability. Much evidence shows that SGK1 is over-expressed in a variety of epithelial tumors. More recently, many contributions to the published literature demonstrate that SGK1 can mediate chemo- and radio-resistance during the treatment of various human tumors, both in vitro and in vivo. SGK1 appears therefore as a dirty player in the stress response to chemical and radio agents, responsible of a selective advantage that favors the uncontrolled tumor progression and the selection of the most aggressive clones. The purpose of this review is the analysis of the literature describing SGK1 as central node of the cell resistance, and a summary of the possible strategies in the pharmacological targeting of SGK1. (C) 2016 The Author(s) Published by S. Karger AG, Basel
C1 [Talarico, Cristina; Dattilo, Vincenzo; D'Antona, Lucia; Menniti, Miranda; Ortuso, Francesco; Alcaro, Stefano; Perrotti, Nicola; Amato, Rosario] Magna Graecia Univ Catanzaro, Dept Sci Salute, Viale Europa, Catanzaro, Italy.
   [Bianco, Cataldo] Magna Graecia Univ Catanzaro, Dept Med Sperimentale & Clin, Viale Europa, Catanzaro, Italy.
   [Schenone, Silvia] Univ Genoa, Dept Farm, Genoa, Italy.
C3 Magna Graecia University of Catanzaro; Magna Graecia University of
   Catanzaro; University of Genoa
RP Perrotti, N; Amato, R (corresponding author), Magna Graecia Univ Catanzaro, Dept Sci Salute, Viale Europa, Catanzaro, Italy.
EM perrotti@unicz.it; rosario.amato@unicz.it
RI dattilo, vincenzino/N-9732-2015; Schenone, Stefano/LFS-2959-2024
OI ALCARO, Stefano/0000-0002-0437-358X; ORTUSO,
   Francesco/0000-0001-6235-8161; Dattilo, Vincenzo/0000-0001-8493-6188;
   Amato, Rosario/0000-0001-7162-1099
FU FIRB Young Investigator grant [BFR12NSCF_003]; AIRC [16971]
FX This work was supported by FIRB BFR12NSCF_003 Young Investigator grant
   and AIRC project code 16971.
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NR 90
TC 71
Z9 76
U1 0
U2 18
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1015-8987
EI 1421-9778
J9 CELL PHYSIOL BIOCHEM
JI Cell. Physiol. Biochem.
PY 2016
VL 39
IS 5
BP 1863
EP 1876
DI 10.1159/000447885
PG 14
WC Cell Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Physiology
GA EC9ZT
UT WOS:000388503500018
PM 27771704
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Zhang, JX
   Xiang, GD
   Xiang, L
   Dong, J
AF Zhang, Jun-Xia
   Xiang, Guang-Da
   Xiang, Lin
   Dong, Jing
TI Serum gamma-glutamyl transferase is associated with the elevated uric
   acid levels in normotensive Chinese adults
SO CLINICA CHIMICA ACTA
LA English
DT Article
DE Gamma-glutamyl transferase; Uric acid; Normotensive; Cardiovascular
   disease
ID METABOLIC SYNDROME; INSULIN-RESISTANCE; BLOOD-PRESSURE; OXIDATIVE
   STRESS; CARDIOVASCULAR-DISEASE; US ADULTS; RISK; GLUTAMYLTRANSFERASE;
   HYPERTENSION; MARKER
AB Background: Although both serum gamma-glutamyltransferase (GGT) and uric acid are correlated with hypertension, studies on the association between serum GGT and uric acid in normotensive individuals are rare. In this study, we tried to reveal this relationship in normotensive Chinese adults.
   Methods: Four hundred seven normotensive adults were recruited. The subjects were divided into 3 subgroups according to serum GGT tertiles. Anthropometric parameters as well as systolic blood pressure (SBP), diastolic blood pressure (DBP), uric acid, GGT, alanine aminotransferase (ALT), aspartate aminotransferase (AST), blood glucose, blood lipids, and fasting insulin were measured. Insulin resistance was assessed using HOMA-IR index.
   Results: Uric acid was increased in parallel with increasing serum GGT (P < 0.001). After correction for age, sex, smoking and alcohol consumption, serum GGT was positively associated with uric acid (r = 0.42, P < 0.001), SBP (r = 0.22, P < 0.001), and DBP (r = 0.19, P < 0.001). When compared with lowest GGT tertile, the odds ratio of the middle fertile for the increased serum uric acid was 3.43 (95% CI, 1.39-8.47) and 7.29 (95% CI, 1.57-33.82) for the highest fertile after adjustment for age, sex, BMI, smoking, alcohol consumption, SBP, DBP, creatinine and HOMA-IR.
   Conclusions: Serum GGT is strongly associated with the increased uric acid concentrations in normotensive Chinese adults. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Zhang, Jun-Xia; Xiang, Guang-Da; Xiang, Lin; Dong, Jing] Wuhan Gen Hosp Guangzhou Command, Dept Endocrinol, Wuhan 430070, Hubei Province, Peoples R China.
RP Zhang, JX (corresponding author), Wuhan Gen Hosp Guangzhou Command, Dept Endocrinol, Wuluo Rd 627, Wuhan 430070, Hubei Province, Peoples R China.
EM zhangjx023@163.com
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NR 33
TC 11
Z9 12
U1 1
U2 10
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0009-8981
EI 1873-3492
J9 CLIN CHIM ACTA
JI Clin. Chim. Acta
PD FEB 20
PY 2015
VL 441
BP 122
EP 126
DI 10.1016/j.cca.2014.12.031
PG 5
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA CC1EZ
UT WOS:000350085300022
PM 25545230
DA 2025-06-11
ER

PT J
AU Orr, JS
   Kennedy, A
   Anderson-Baucum, EK
   Webb, CD
   Fordahl, SC
   Erikson, KM
   Zhang, YF
   Etzerodt, A
   Moestrup, SK
   Hasty, AH
AF Orr, Jeb S.
   Kennedy, Arion
   Anderson-Baucum, Emily K.
   Webb, Corey D.
   Fordahl, Steve C.
   Erikson, Keith M.
   Zhang, Yaofang
   Etzerodt, Anders
   Moestrup, Soren K.
   Hasty, Alyssa H.
TI Obesity Alters Adipose Tissue Macrophage Iron Content and Tissue Iron
   Distribution
SO DIABETES
LA English
DT Article
ID FATTY LIVER-DISEASE; TRANSFERRIN RECEPTORS; INSULIN-RESISTANCE;
   METABOLIC SYNDROME; STRESS; DIFFERENTIATION; REDISTRIBUTION;
   INFLAMMATION; RESTRICTION; EXPRESSION
AB Adipose tissue (AT) expansion is accompanied by the infiltration and accumulation of AT macrophages (ATMs), as well as a shift in ATM polarization. Several studies have implicated recruited M1 ATMs in the metabolic consequences of obesity; however, little is known regarding the role of alternatively activated resident M2 ATMs in AT homeostasis or how their function is altered in obesity. Herein, we report the discovery of a population of alternatively activated ATMs with elevated cellular iron content and an iron-recycling gene expression profile. These iron-rich ATMs are referred to as MFehi, and the remaining ATMs are referred to as MFelo. In lean mice, similar to 25% of the ATMs are MFehi; this percentage decreases in obesity owing to the recruitment of MFelo macrophages. Similar to MFelo cells, MFehi ATMs undergo an inflammatory shift in obesity. In vivo, obesity reduces the iron content of MFehi ATMs and the gene expression of iron importers as well as the iron exporter, ferroportin, suggesting an impaired ability to handle iron. In vitro, exposure of primary peritoneal macrophages to saturated fatty acids also alters iron metabolism gene expression. Finally, the impaired MFehi iron handling coincides with adipocyte iron overload in obese mice. In conclusion, in obesity, iron distribution is altered both at the cellular and tissue levels, with AT playing a predominant role in this change. An increased availability of fatty acids during obesity may contribute to the observed changes in MFehi ATM phenotype and their reduced capacity to handle iron.
C1 [Orr, Jeb S.; Kennedy, Arion; Anderson-Baucum, Emily K.; Webb, Corey D.; Hasty, Alyssa H.] Vanderbilt Univ, Sch Med, Dept Mol Physiol & Biophys, Nashville, TN 37212 USA.
   [Fordahl, Steve C.; Erikson, Keith M.] Univ N Carolina, Dept Nutr, Greensboro, NC 27412 USA.
   [Zhang, Yaofang] Vanderbilt Univ, Sch Med, Dept Pathol Microbiol & Immunol, Nashville, TN 37212 USA.
   [Etzerodt, Anders; Moestrup, Soren K.] Aarhus Univ, Dept Biomed, Aarhus, Denmark.
C3 Vanderbilt University; University of North Carolina; University of North
   Carolina Greensboro; Vanderbilt University; Aarhus University
RP Hasty, AH (corresponding author), Vanderbilt Univ, Sch Med, Dept Mol Physiol & Biophys, Nashville, TN 37212 USA.
EM alyssa.hasty@vanderbilt.edu
RI Moestrup, Søren/AAD-1735-2019; Etzerodt, Anders/O-9860-2019; Hasty,
   Alyssa/AAA-2757-2020; Moestrup, Soren Kragh/A-1403-2014; Etzerodt,
   Anders/E-2839-2013
OI Fordahl, Steven/0000-0002-7093-6774; Kennedy, Arion/0000-0002-8443-3131;
   Moestrup, Soren Kragh/0000-0003-3862-2107; Etzerodt,
   Anders/0000-0002-6757-2068; Hasty, Alyssa/0000-0001-7302-8045
FU Discovery Grant in Innovative Diabetes Research from the Vanderbilt
   Diabetes Center [DK-20593]; National Institutes of Health (NIH) [R21
   DK-095456]; NIH Ruth L. Kirschstein NRSA [F32 DK-091040]; American
   Diabetes Association Mentor-based Postdoctoral Fellowship [7-10-MI-05];
   American Heart Association Pre-doctoral Fellowship [12PRE11910047]; NIH
   [DK-20593, R21 DK-095456, DK-058404, CA-68485, DK-58404, HD-15052,
   DK-59637, EY-08126]; American Heart Association Established Investigator
   Award [12EIA8270000]; NIH Shared Instrumentation grant [S10 RR-026742]; 
   [DK-059637]; American Heart Association (AHA) [12PRE11910047,
   12EIA8270000] Funding Source: American Heart Association (AHA)
FX This project was supported by a Discovery Grant in Innovative Diabetes
   Research from the Vanderbilt Diabetes Center (DK-20593) and National
   Institutes of Health (NIH) R21 DK-095456. The authors were supported by
   the following grants: NIH Ruth L. Kirschstein NRSA F32 DK-091040 (to
   J.S.O.), American Diabetes Association Mentor-based Postdoctoral
   Fellowship 7-10-MI-05 (to A.K.), American Heart Association Pre-doctoral
   Fellowship 12PRE11910047 (to E.K.A.-B.), NIH R21 DK-095456 (to C.D.W.
   and A.H.H.), and American Heart Association Established Investigator
   Award 12EIA8270000 (to A.H.H.). Flow cytometry was performed through
   Vanderbilt University Medical Center (VUMC) Digestive Disease Research
   Center supported by NIH DK-058404 Core Scholarship. Cellular iron
   measurements were performed by the VUMC Mass Spectrometry Research Core
   (supported by NIH Shared Instrumentation grant S10 RR-026742).
   Immunofluorescence imaging was conducted in part through the use of the
   VUMC Cell Imaging Shared Resource (supported by NIH grants CA-68485,
   DK-20593, DK-58404, HD-15052, DK-59637, and EY-08126). Serum iron
   parameter measurements were performed by the Vanderbilt Translational
   Pathology Shared Resource (supported by DK-059637).
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NR 42
TC 129
Z9 137
U1 0
U2 19
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0012-1797
EI 1939-327X
J9 DIABETES
JI Diabetes
PD FEB
PY 2014
VL 63
IS 2
BP 421
EP 432
DI 10.2337/db13-0213
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA AA5BG
UT WOS:000331110000012
PM 24130337
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Lee, SY
   Sung, E
   Chang, Y
AF Lee, Seon Yeong
   Sung, Eunju
   Chang, Yoosoo
TI Elevated Serum Gamma-Glutamyltransferase Is a Strong Marker of Insulin
   Resistance in Obese Children
SO INTERNATIONAL JOURNAL OF ENDOCRINOLOGY
LA English
DT Article
ID FATTY LIVER-DISEASE; ALANINE AMINOTRANSFERASE; CARDIOVASCULAR RISK;
   METABOLIC SYNDROME; OXIDATIVE STRESS; YOUNG-ADULTS; TRANSPEPTIDASE;
   GLUTAMYLTRANSFERASE; ASSOCIATION; PREVALENCE
AB Elevated levels of serum gamma-glutamyltransferase (GGT) levels have been found to predict the development of type 2 diabetes in adults. The role of GGT in insulin resistance (IR) among children is largely unknown. We investigated whether GGT among hepatic enzymes is independently associated with IR in obese Korean children. A total of 1308 overweight (above the 85th BMI percentile of Korean reference) boys (n = 822) and girls (n = 486), aged 9-15 years, were studied. Measures acquired included weight, height, percent body fat (BF%), waist circumference, blood pressure, blood glucose and insulin, C-reactive protein, total cholesterol, triglycerides, HDL-Cholesterol, GGT, aspartate aminotransferase (AST), and alanine aminotransferase (ALT). IR was calculated using the homeostasis model assessment (HOMA-IR). Serum GGT and ALT, but not AST, were positively correlated with HOMA-IR in boys (r = 0.222 for GGT; P < 0.05, r = 0.188 for ALT; P < 0.05) and girls (r = 0.292 for GGT; P < 0.05, r = 0.258 for ALT; P < 0.05). In multiple regression analysis for HOMA-IR as dependent variable, GGT (beta = 0.068; P = 0.053 in boys, beta = 0.145; P = 0.002 in girls) and ALT (beta = 0.074; P = 0.034 in boys, beta = 0.130; P = 0.005 in girls) emerged as determinants of HOMA-IR after adjusting age, BMI, tanner stage, and triglycerides. Serum GGT level is a strong marker of IR in obese Korean children.
C1 [Lee, Seon Yeong] Inje Univ, Sanggyepaik Hosp, Coll Med, Dept Family Med, Seoul 139707, South Korea.
   [Sung, Eunju] Sungkyunkwan Univ, Sch Med, Kangbuk Samsung Hosp, Dept Family Med, Seoul 110746, South Korea.
   [Chang, Yoosoo] Sungkyunkwan Univ, Sch Med, Kangbuk Samsung Hosp, Dept Occupat Med, Seoul 110746, South Korea.
   [Chang, Yoosoo] Sungkyunkwan Univ, Sch Med, Kangbuk Samsung Hosp, Hlth Screening Ctr, Seoul 110746, South Korea.
C3 Inje University; Sungkyunkwan University (SKKU); Samsung Medical Center;
   Sungkyunkwan University (SKKU); Samsung Medical Center; Sungkyunkwan
   University (SKKU); Samsung Medical Center
RP Sung, E (corresponding author), Sungkyunkwan Univ, Sch Med, Kangbuk Samsung Hosp, Dept Family Med, 108 Pyongdong, Seoul 110746, South Korea.
EM green@medimail.co.kr
FU Samsung Medical Research Institute [SBRI C-A6-312-1]; Inje University
FX This study was supported by the Samsung Medical Research Institute
   Grant, no. SBRI C-A6-312-1 and the Grant from Inje University 2008.
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   Vozarova B., 2001, DIABETES, V51, P1889
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NR 36
TC 16
Z9 16
U1 0
U2 10
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1687-8337
EI 1687-8345
J9 INT J ENDOCRINOL
JI Int. J. Endocrinol.
PY 2013
VL 2013
AR 578693
DI 10.1155/2013/578693
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 110UF
UT WOS:000316471500001
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Gvozdjakova, A
   Kucharska, J
   Tkacov, M
   Singh, RB
   Hlavata, A
AF Gvozdjakova, A.
   Kucharska, J.
   Tkacov, M.
   Singh, R. B.
   Hlavata, A.
TI Ratio of lipid parameters to coenzyme Q10 could be used as
   biomarker of the development of early complications of obesity in
   children
SO BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY
LA English
DT Article
DE child obesity; coenzyme Q(10); ratio of lipid fractions/coenzyme Q(10)
ID PLASMA; CHILDHOOD; HEART; RISK
AB Background: Chronic obesity is associated with reduced levels of antioxidants, increased free oxygen radicals, and oxidative stress. Child obesity may lead to the development of complications, such as changes in metabolism, metabolic syndrome, neurological, cardiological, respiratory, renal, gastrointestinal, endocrinological, and musculoskeletal conditions.
   The aim of the present study is to establish whether there is a correlation between basal CoQ(10) plasma concentration and the ratio of lipid parameters to CoQ(10) in obese children.
   Methods: The study included 101 obese children and 20 non-obese children, aged 10-18 years. Antioxidants - CoQ(10-OX), a-tocopherol, beta-carotene - in plasma were measured by HPLC method with UV detector, and plasma malondialdehyde spectrophotometrically.
   Results: High correlation was found between plasma concentration of CoQ(10) and the ratio of total Chol/CoQ(10-OX) as well as between CoQ(10-OX) and the ratio of HDL Chol/CoQ(10) in plasma of obese children. The lowest correlation was between plasma concentration of CoQ(10-OX) and the ratio of LDL Chol/CoQ(10). as well as between CoQ(10-OX) and the ratio of TAG/CoQ(10) in obese children.
   Conclusion: An increase of the ratios of lipid parameters to CoQ(10) is associated with child obesity and could be used as biomarkers of early complications in the development of obesity in children (Tab. 3, Fig. 5, Ref. 22). Full Text in free PDF www.bmj.sk.
C1 [Gvozdjakova, A.; Kucharska, J.; Tkacov, M.] Comenius Univ, Fac Med, Pharmacobiochem Lab, Dept Med 3, SK-81105 Bratislava, Slovakia.
   [Hlavata, A.] Comenius Univ, Fac Med, Children Hosp 2, Metab Dept, SK-81105 Bratislava, Slovakia.
C3 Comenius University Bratislava; Comenius University Bratislava
RP Gvozdjakova, A (corresponding author), Comenius Univ, Fac Med, Pharmacobiochem Lab, Dept Med 3, Sasinkova 4, SK-81105 Bratislava, Slovakia.
EM anna.gvozdjakova@fmed.uniba.sk
FU Ministry of Education of Slovakia [VEGA 1/0328/10]
FX For the grant of the Ministry of Education of Slovakia, VEGA 1/0328/10
   and A. Stetkova for technical assistance.
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NR 22
TC 5
Z9 5
U1 0
U2 5
PU COMENIUS UNIV
PI BRATISLAVA I
PA SCH MEDICINE, SPITALSKA 24, BRATISLAVA I, SK-813 72, SLOVAKIA
SN 0006-9248
EI 1336-0345
J9 BRATISL MED J
JI Bratisl. Med. J.
PY 2012
VL 113
IS 1
BP 21
EP 25
DI 10.4149/BLL_2012_005
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 883WK
UT WOS:000299665400005
PM 22380497
OA Bronze
DA 2025-06-11
ER

PT J
AU Picciotto, S
   Forastiere, F
   Pistelli, R
   Koenig, W
   Lanki, T
   Ljungman, P
   Pitsavos, C
   Ruckerl, R
   Sunyer, J
   Peters, A
AF Picciotto, Sally
   Forastiere, Francesco
   Pistelli, Riccardo
   Koenig, Wolfgang
   Lanki, Timo
   Ljungman, Petter
   Pitsavos, Christos
   Ruckerl, Regina
   Sunyer, Jordi
   Peters, Annette
TI Determinants of plasma interleukin-6 levels among survivors of
   myocardial infarction
SO EUROPEAN JOURNAL OF CARDIOVASCULAR PREVENTION & REHABILITATION
LA English
DT Article
DE cardiovascular risk factors; cytokines; inflammation; interleukin-6;
   myocardial infarction
ID CARDIOVASCULAR RISK-FACTORS; CORONARY-ARTERY-DISEASE; C-REACTIVE
   PROTEIN; INFLAMMATORY MARKERS; HEART-DISEASE; METABOLIC SYNDROME;
   ADIPOSE-TISSUE; MEN; IL-6; CYTOKINES
AB Background We identify determinants of plasma interleukin-6 (IL-6) levels in a multicenter panel study of myocardial infarction (MI) survivors, using repeated measurements to evaluate both baseline and time-varying factors.
   Design and methods Survivors of MI (N=1003) recruited in six European cities had repeated measurements (median: 6/patient) of IL-6. At baseline, participants' behaviour and medical histories were determined by interview, and blood pressure, anthropometry, cholesterol and N-terminal B-type natriuretic peptide (NT-proBNP) were measured. Short-term exposures and medication intake were recorded at each visit. Generalized additive mixed models were used to analyze associations of IL-6 with baseline and time-varying risk factors, taking into account repeated measurements.
   Results Age, hour of blood withdrawal, body mass index, pack-years of smoking, NT-proBNP, systolic blood pressure, high-density lipoprotein cholesterol, persistent cough/phlegm and statin use were significantly and independently associated with IL-6 after adjustment for city, recurrent MI, baseline alcohol intake, current active smoking, tea consumption and extreme anger or stress.
   Conclusion Among MI survivors, IL-6 levels are associated with many traditional cardiovascular risk factors. Patients with elevated NT-proBNP, respiratory symptoms or obesity had higher IL-6 concentrations and may potentially be at greater risk for coronary artery disease progression. Eur J Cardiovasc Prev Rehabil 15:631-638 (C) 2008 The European Society of Cardiology
C1 [Koenig, Wolfgang] Univ Ulm, Med Ctr, Dept Internal Med Cardiol 2, D-89081 Ulm, Germany.
   [Picciotto, Sally; Forastiere, Francesco] ASL RME, Dept Epidemiol, Local Hlth Author, Rome, Italy.
   [Pistelli, Riccardo] Univ Cattolica Sacro Cuore, Rome, Italy.
   [Ruckerl, Regina; Peters, Annette] Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Epidemiol, Munich, Germany.
   [Ljungman, Petter] Stockholm S Hosp, Dept Cardiol, Stockholm, Sweden.
   [Pitsavos, Christos] Univ Athens, Sch Med, Ippokrat Hosp, Dept Cardiol, GR-11527 Athens, Greece.
   [Lanki, Timo] Natl Publ Hlth Inst KTL, Environm Epidemiol Unit, Kuopio, Finland.
   [Sunyer, Jordi] Res Ctr Environm Epidemiol CREAL, Barcelona, Spain.
C3 Ulm University; Catholic University of the Sacred Heart; IRCCS
   Policlinico Gemelli; Helmholtz Association; Helmholtz-Center Munich -
   German Research Center for Environmental Health; National & Kapodistrian
   University of Athens; Athens Medical School; Finland National Institute
   for Health & Welfare; Pompeu Fabra University; Centre de Recerca en
   Epidemiologia Ambiental (CREAL)
RP Koenig, W (corresponding author), Univ Ulm, Med Ctr, Dept Internal Med Cardiol 2, Robert Koch Str 8, D-89081 Ulm, Germany.
EM wolfgang.koenig@uniklinik-ulm.de
RI Koenig, Wolfgang/JCF-0788-2023; Ljungman, Petter/C-6371-2014; Peters,
   Annette/A-6117-2011; Forastiere, Francesco/J-9067-2016; Sunyer Deu,
   Jordi/G-6909-2014
OI Ljungman, Petter/0000-0002-7815-2632; Peters,
   Annette/0000-0001-6645-0985; Koenig, Wolfgang/0000-0002-2064-9603;
   Forastiere, Francesco/0000-0002-9162-5684; Sunyer Deu,
   Jordi/0000-0002-2602-4110
FU European Union's 5th Framework Programme [QLRT-2002-02236]
FX The AIRGENE study was funded as part of the European Union's 5th
   Framework Programme, key action number 4: 'Environment and Health',
   contract number QLRT-2002-02236.
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NR 32
TC 8
Z9 9
U1 0
U2 3
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1741-8267
EI 1741-8275
J9 EUR J CARDIOV PREV R
JI Eur. J. Cardiovasc. Prev. Rehabil.
PD DEC
PY 2008
VL 15
IS 6
BP 631
EP 638
DI 10.1097/HJR.0b013e3283069d9a
PG 8
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 389CF
UT WOS:000262067200003
PM 19177625
DA 2025-06-11
ER

PT J
AU Eskurza, I
   Myerburgh, LA
   Kahn, ZD
   Seals, DR
AF Eskurza, I
   Myerburgh, LA
   Kahn, ZD
   Seals, DR
TI Tetrahydrobiopterin augments endothelium-dependent dilatation in
   sedentary but not in habitually exercising older adults
SO JOURNAL OF PHYSIOLOGY-LONDON
LA English
DT Article
ID NITRIC-OXIDE SYNTHASE; FLOW-MEDIATED DILATATION; BRACHIAL-ARTERY;
   METABOLIC SYNDROME; ASCORBIC-ACID; GENE-TRANSFER; SUPEROXIDE; AGE;
   VASODILATION; DYSFUNCTION
AB Endothelium-dependent dilatation (EDD) is impaired with ageing in sedentary, but not in regularly exercising adults. We tested the hypotheses that differences in tetrahydrobiopterin (BH4) bioactivity are key mechanisms explaining the impairment in EDD with sedentary ageing, and the maintenance of EDD with ageing in regularly exercising adults. Brachial artery flow-mediated dilatation (FMD), normalized for local shear stress, was measured after acute oral placebo or BH4 in young sedentary (YS) (n = 10; 22 +/- 1 years, mean S.E.M.), older sedentary (OS) (n = 9; 62 2), and older habitually aerobically trained (OT) (n = 12; 66 1) healthy men. At baseline, FMD was similar to 50% lower in OS versus YS (1.12 +/- 0.09 versus 0.57 +/- 0.09 (Delta mm (dyn cm(-2))) X 10(-2), p < 0.001; 1 dyn = 10(-5) N), but was preserved in OT (0.93 +/- 0.08 (Delta mm (dyn cm(-2))) X 10(-2)). BH4 administration improved FMD by similar to 45% in OS (1.00 +/- 0.10 (Delta mm (dyn cm(-2))) X 10(-2), p < 0.01 versus baseline), but did not affect FMD in YS or OT. Endothelium-independent dilatation neither differed between groups at baseline nor changed with BH4 administration. These results suggest that BH4 bioactivity may be a key mechanism involved in the impairment of conduit artery EDD with sedentary ageing, and the EDD-preserving effect of habitual exercise.
C1 Univ Colorado, Dept Integrat Physiol, Boulder, CO 80309 USA.
C3 University of Colorado System; University of Colorado Boulder
RP Univ Colorado, Dept Integrat Physiol, UCB 354, Boulder, CO 80309 USA.
EM eskurza@colourado.edu
FU NCRR NIH HHS [M01 RR000051, RR00051] Funding Source: Medline; NIA NIH
   HHS [AG13038, R01 AG013038, R37 AG013038, R01 AG006537, AG06537] Funding
   Source: Medline
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NR 56
TC 141
Z9 167
U1 0
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-3751
EI 1469-7793
J9 J PHYSIOL-LONDON
JI J. Physiol.-London
PD NOV 1
PY 2005
VL 568
IS 3
BP 1057
EP 1065
DI 10.1113/jphysiol.2005.092734
PG 9
WC Neurosciences; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Physiology
GA 983EI
UT WOS:000233213500027
PM 16141271
OA Green Published
DA 2025-06-11
ER

PT J
AU Simental-Mendía, LE
   Pirro, M
   Gotto, AM
   Banach, M
   Atkin, SL
   Majeed, M
   Sahebkar, A
AF Simental-Mendia, Luis E.
   Pirro, Matteo
   Gotto, Antonio M.
   Banach, Maciej
   Atkin, Stephen L.
   Majeed, Muhammed
   Sahebkar, Amirhossein
TI Lipid-modifying activity of curcuminoids: A systematic review and
   meta-analysis of randomized controlled trials
SO CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
LA English
DT Review
DE Curcumin; Turmeric; Dyslipidemia; Cardiovascular disease; Cholesterol;
   Triglycerides
ID RESIDUAL CARDIOVASCULAR RISK; TYPE-2 DIABETES-MELLITUS; FATTY
   LIVER-DISEASE; QUALITY-OF-LIFE; DOUBLE-BLIND; ATHEROGENIC DYSLIPIDEMIA;
   METABOLIC SYNDROME; OXIDATIVE STRESS; CURCUMA-LONGA; HEART-DISEASE
AB Objective: The aim of this systematic review and meta-analysis was to determine and clarify the impact of curcuminoids on serum lipid levels. Methods: Randomized controlled trials (RCTs) investigating the effects of curcuminoids on plasma lipids were searched in PubMed-Medline, Scopus, Web of Science databases (from inception to April 3(rd), 2017). A random-effects model and generic inverse variance method were used for quantitative data synthesis. Sensitivity analysis was conducted using the leave-one-out method. A weighted random-effects meta-regression was performed to evaluate the impact of potential confounders on lipid concentrations. Results: A meta-analysis of 20 RCTs with 1427 participants suggested a significant decrease in plasma concentrations of triglycerides (WMD: -21.36mg/dL, 95% CI: -32.18, -10.53, p < 0.001), and an elevation in plasma HDL-C levels (WMD: 1.42mg/dL, 95% CI: 0.03, 2.81, p = 0.046), while plasma levels of LDL-C (WMD: -5.82mg/dL, 95% CI: -15.80, 4.16, p = 0.253) and total cholesterol (WMD: -9.57mg/dL, 95% CI: -20.89, 1.75, p = 0.098) were not altered. The effects of curcuminoids on lipids were not found to be dependent on the duration of supplementation. Conclusion: This meta-analysis has shown that curcuminoid therapy significantly reduces plasma triglycerides and increases HDL-C levels.
C1 [Simental-Mendia, Luis E.] Mexican Social Secur Inst, Biomed Res Unit, Durango, Mexico.
   [Pirro, Matteo] Univ Perugia, Dept Med, Unit Internal Med Angiol & Arteriosclerosis Dis, Perugia, Italy.
   [Gotto, Antonio M.] Weill Cornell Med Coll, New York, NY USA.
   [Banach, Maciej] Med Univ Lodz, WAM Univ Hosp Lodz, Dept Hypertens, Zeromskiego 113, Lodz, Poland.
   [Banach, Maciej] PMMHRI, Lodz, Poland.
   [Atkin, Stephen L.] Weill Cornell Med Qatar, Doha, Qatar.
   [Majeed, Muhammed] Sabinsa Corp, East Windsor, NJ USA.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Biotechnol Res Ctr, Mashhad, Razavi Khorasan, Iran.
C3 Instituto Mexicano del Seguro Social; University of Perugia; Cornell
   University; Weill Cornell Medicine; Medical University Lodz; Qatar
   Foundation (QF); Weill Cornell Medical College Qatar; Mashhad University
   of Medical Sciences
RP Sahebkar, A (corresponding author), Mashhad Univ Med Sci, Sch Med, Dept Med Biotechnol, POB 91779-48564, Mashhad, Razavi Khorasan, Iran.
EM sahebkara@mums.ac.ir
RI Banach, Maciej/A-1271-2009; Pirro, Matteo/AAC-2318-2022; Sahebkar,
   Amirhossein/B-5124-2018; Atkin, stephen/ABE-7047-2020
OI Pirro, Matteo/0000-0002-5527-4821
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NR 66
TC 60
Z9 60
U1 1
U2 29
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1040-8398
EI 1549-7852
J9 CRIT REV FOOD SCI
JI Crit. Rev. Food Sci. Nutr.
PD APR 12
PY 2019
VL 59
IS 7
BP 1178
EP 1187
DI 10.1080/10408398.2017.1396201
PG 10
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA IK9VD
UT WOS:000476943900012
PM 29185808
DA 2025-06-11
ER

PT J
AU Al-Anazi, A
   Parhar, R
   Saleh, S
   Al-Hijailan, R
   Inglis, A
   Al-Jufan, M
   Bazzi, M
   Hashmi, S
   Conca, W
   Collison, K
   Al-Mohanna, F
AF Al-Anazi, Azizah
   Parhar, Ranjit
   Saleh, Soad
   Al-Hijailan, Reem
   Inglis, Angela
   Al-Jufan, Mansour
   Bazzi, Mohammed
   Hashmi, Sarwar
   Conca, Walter
   Collison, Kate
   Al-Mohanna, Futwan
TI Intracellular calcium and NF-kB regulate hypoxia-induced
   leptin, VEGF, IL-6 and adiponectin secretion in human adipocytes
SO LIFE SCIENCES
LA English
DT Article
DE Mitochondria; Calcium; ROS, adipokines; Oscillations; Hypoxia
ID ADIPOSE-TISSUE HYPOXIA; MITOCHONDRIAL DYSFUNCTION; STROMAL/STEM CELLS;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; 3T3-L1 ADIPOCYTES; KAPPA-B;
   OBESITY; DIFFERENTIATION; INFLAMMATION
AB Aims: Hypoxia-induced adipokine release has been attributed mainly to HIF-1 alpha. Here we investigate the role of intracellular calcium and NF-kB in the hypoxia-dependent release of leptin, VEGF, IL-6 and the hypoxia-induced inhibition of adiponectin release in human adipocytes.
   Main methods: We used intracellular calcium imaging to compare calcium status in preadipocytes and in adipocytes. We subjected both cell types to hypoxic conditions and measured the release of adipokines induced by hypoxia in the presence and absence of HIF-1 alpha inhibitor YC-1, NF-B-kappa inhibitor SN50 and intracellular calcium chelator BAPTA-AM.
   Key findings: We demonstrate reduced intracellular calcium oscillations and increased oxidative stress as the cells transitioned from preadipocytes to adipocytes. We show that differentiation of preadipocytes to adipocytes is associated with distinct morphological changes in the mitochondria. We also show that hypoxia-induced secretion of leptin, VEGF, IL-6 and hypoxia-induced inhibition of adiponectin secretion are independent of HIF-1 alpha expression. The hypoxia-induced leptin, VEGF and IL-6 release are [Ca++](i) dependent whereas adiponectin is NF-B-k dependent.
   Significance: Our work suggests a major role for [Ca++](i) in preadipocyte differentiation to adipocytes and that changes in mitochondrial morphology in the adipocytes might underlie the reduced calcium oscillations observed in the adipocytes. It also demonstrates that multiple signaling pathways are associated with the hypoxia-induced adipokine secretion.
C1 [Al-Anazi, Azizah; Parhar, Ranjit; Saleh, Soad; Al-Hijailan, Reem; Inglis, Angela; Conca, Walter; Collison, Kate; Al-Mohanna, Futwan] King Faisal Specialist Hosp & Res Ctr, Dept Cell Biol, Riyadh 11211, Saudi Arabia.
   [Al-Jufan, Mansour] King Faisal Specialist Hosp & Res Ctr, Ctr Heart, Riyadh 11211, Saudi Arabia.
   [Bazzi, Mohammed] King Saud Univ, Dept Biochem, Coll Sci, Riyadh 12372, Saudi Arabia.
   [Hashmi, Sarwar] Rutgers State Univ, Ctr Vector Biol, Dev Biol, New Brunswick, NJ 08901 USA.
   [Conca, Walter] King Faisal Specialist Hosp & Res Ctr, Dept Med, Riyadh 11211, Saudi Arabia.
   [Conca, Walter; Al-Mohanna, Futwan] Alfaisal Univ, Coll Med, Riyadh 11211, Saudi Arabia.
C3 King Faisal Specialist Hospital & Research Center; King Faisal
   Specialist Hospital & Research Center; King Saud University; Rutgers
   University System; Rutgers University New Brunswick; King Faisal
   Specialist Hospital & Research Center
RP Al-Mohanna, F (corresponding author), King Faisal Specialist Hosp & Res Ctr, Dept Cell Biol, Riyadh 11211, Saudi Arabia.
EM futwan@kfshrc.edu.sa
RI AL Hijailan, Reem/IQU-5128-2023; Saleh, SOAD/KIB-4260-2024; Inglis,
   Angela/IXN-5890-2023
OI Inglis, Angela/0009-0008-0756-2707; ALJUFAN,
   MANSOUR/0000-0002-6074-1500; SALEH, SOAD/0009-0008-3368-3465; AL
   Hijailan, Reem/0009-0009-2706-2272; Conca, Walter/0000-0003-3427-2664
FU King Abdulaziz City for Science and Technology [KACST 0968-12]; KFSHRC
   research funds
FX We are thankful to Dr. Rachid Sougrat (KAUST) for performing TEM and Mr.
   Mohammed Halabi for technical assistance. Our gratitude to Ms. Camelia
   Touzinte and Mr. Melvin Velasco for editorial assistance and to Mr. John
   Schneider for technical assistance. The authors are indebted to the
   KFSHRC Research Centre Administration, Training and Education Office.
   The work was partially supported by King Abdulaziz City for Science and
   Technology grant number KACST 0968-12 and KFSHRC research funds. There
   are no conflicts of interest to declare.
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NR 82
TC 29
Z9 29
U1 0
U2 8
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0024-3205
EI 1879-0631
J9 LIFE SCI
JI Life Sci.
PD NOV 1
PY 2018
VL 212
BP 275
EP 284
DI 10.1016/j.lfs.2018.10.014
PG 10
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA GX3TI
UT WOS:000447649400031
PM 30308181
OA hybrid
DA 2025-06-11
ER

PT J
AU Chung, J
   Kim, M
   Jin, Y
   Kim, Y
   Hong, J
AF Chung, Jinwook
   Kim, Milyang
   Jin, Youngsoo
   Kim, Yonghwan
   Hong, Jeeyoung
TI Fitness as a determinant of arterial stiffness in healthy adult men: a
   cross-sectional study
SO JOURNAL OF SPORTS MEDICINE AND PHYSICAL FITNESS
LA English
DT Article
DE Vascular stiffness; Physical fitness; Healthy volunteers
ID PULSE-WAVE VELOCITY; RESISTANCE EXERCISE; PHYSICAL-ACTIVITY; YOUNG; AGE;
   STRENGTH; REFLECTION; PRESSURE; RISK
AB BACKGROUND: Fitness is known to influence arterial stiffness. This study aimed to assess differences in cardiorespiratory endurance, muscular strength, and flexibility according to arterial stiffness, based on sex and age.
   METHODS: We enrolled 1590 healthy adults (men: 1242, women: 348) who were free of metabolic syndrome. We measured cardiorespiratory endurance in an exercise stress test on a treadmill, muscular strength by a grip test, and flexibility by upper body forward-bends from a standing position. The brachial-ankle pulse wave velocity test was performed to measure arterial stiffness before the fitness test. Cluster analysis was performed to divide the patients into groups with low (Cluster 1) and high (Cluster 2) arterial stiffness. According to the k-cluster analysis results, Cluster 1 included 624 men and 180 women, and Cluster 2 included 618 men and 168 women.
   RESULTS: Men in the middle-aged group with low arterial stiffness demonstrated higher cardiorespiratory endurance, muscular strength, and flexibility than those with high arterial stiffness. Similarly, among men in the old-aged group, the cardiorespiratory endurance and muscular strength, but not flexibility, differed significantly according to arterial stiffness. Women in both clusters showed similar cardiorespiratory endurance, muscular strength, and flexibility regardless of their arterial stiffness.
   CONCLUSIONS: Among healthy adults, arterial stiffness was inversely associated with fitness in men but not in women. Therefore, fitness seems to be a determinant for arterial stiffness in men. Additionally, regular exercise should be recommended for middle-aged men to prevent arterial stiffness.
C1 [Chung, Jinwook] Dongguk Univ Seoul, Dept Sport Culture Sci, Seoul, South Korea.
   [Kim, Milyang] Soonchunhyang Univ, Dept Sport Leisure & Recreat, Asan, South Korea.
   [Jin, Youngsoo; Kim, Yonghwan] Asan Med Ctr, Sports Hlth Med Ctr, Seoul, South Korea.
   [Hong, Jeeyoung] Natl Univ Seoul, Inst Med & Biol Engn, Coll Med, Med Res Ctr, 71 Ihwa Jang Gil, Seoul 03087, South Korea.
   [Hong, Jeeyoung] Natl Univ Hosp Seoul, Dept Biomed Engn, Seoul, South Korea.
C3 Dongguk University; Soonchunhyang University; University of Ulsan; Asan
   Medical Center
RP Hong, J (corresponding author), Natl Univ Seoul, Inst Med & Biol Engn, Coll Med, Med Res Ctr, 71 Ihwa Jang Gil, Seoul 03087, South Korea.
EM hongjee1023@gmail.com
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NR 38
TC 9
Z9 10
U1 0
U2 5
PU EDIZIONI MINERVA MEDICA
PI TURIN
PA CORSO BRAMANTE 83-85 INT JOURNALS DEPT., 10126 TURIN, ITALY
SN 0022-4707
EI 1827-1928
J9 J SPORT MED PHYS FIT
JI J. Sports Med. Phys. Fit.
PD JAN-FEB
PY 2018
VL 58
IS 1-2
BP 150
EP 156
DI 10.23736/S0022-4707.17.06767-6
PG 7
WC Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Sport Sciences
GA GL5ER
UT WOS:000437187000019
PM 28409509
DA 2025-06-11
ER

PT J
AU Shi, JQ
   Shen, WX
   Wang, XZ
   Huang, K
   Zou, CC
AF Shi, Jun-Qi
   Shen, Wen-Xia
   Wang, Xiang-Zhi
   Huang, Ke
   Zou, Chao-Chun
TI Relationship Between Immune Parameters and Non-alcoholic Fatty Liver
   Disease in Obese Children
SO INDIAN PEDIATRICS
LA English
DT Article
DE Cytokine; Interleukin-6; Interleukin-10; Metabolic syndrome; Overweight
ID INSULIN-RESISTANCE; OXIDATIVE STRESS; PROINFLAMMATORY CYTOKINES;
   PATHOGENESIS; INFLAMMATION; ADIPOKINES; EXPRESSION
AB Objective: To investigate the relationship between immune parameters and non-alcoholic fatty liver disease (NAFLD) in obese children.
   Design: Cross-sectional study
   Setting: Hospital-based study in Zhejiang Province, China between July to September 2015.
   Participants: A total of 117 obese children and 209 healthy nonobese children were studied as the obese and control groups. Depending on the severity of NAFLD, the obese group was divided into subgroups 1 (without NAFLD), 2 (with simple fatty liver) and 3 (with steatohepatitis).
   Outcome Measures: Glucose metabolism, lipid metabolism and immune parameters.
   Results: In the obese group, body mass index (BMI), waist-and hip-circumferences, fasting insulin, Homeostasis model of assessment for insulin resistance (HOMA-IR), triglyceride, total cholesterol, low density lipoprotein cholesterol (LDL-C), apolipoprotein (Apo)B/ApoA1, alanine aminotransferase, uric acid, white blood cells, neutrophils percentage, platelet and interleukin (IL)-6 were significantly higher than those in the controls (P < 0.05), while lower high density lipoprotein cholesterol and lymphocyte percentage were noted (P < 0.05). IL-10 in the subgroup 3 was higher than those in the control group, subgroup 1 and 2 (P < 0.05). Logistic regression analysis showed that BMI, LDL-C, HOMA-IR and IL-10 were independent factors of NAFLD (P < 0.05).
   Conclusion: These results support a low-grade chronic inflammation in obese children. Moreover, obesity, dyslipidaemia and IR are risk factors while IL-10 may be a protective factor for NAFLD.
C1 [Shi, Jun-Qi; Shen, Wen-Xia; Wang, Xiang-Zhi; Huang, Ke; Zou, Chao-Chun] Zhejiang Univ, Sch Med, Childrens Hosp, Dept Endocrinol, Hangzhou, Zhejiang, Peoples R China.
C3 Zhejiang University
RP Zou, CC (corresponding author), Zhejiang Univ, Sch Med, Childrens Hosp, Binsheng Rd, Hangzhou 310051, Zhejiang, Peoples R China.
EM zcc14@zju.edu.cn
RI Wang, Xiangzhi/AAH-2957-2019; SHI, JunQi/GYV-0035-2022
FU National Natural Science Foundation of China [81170787, 81670786];
   Zhejiang Health and Family Planning Commission [2016KYA128]; Zhejiang
   Provincial Program for the Cultivation of High-Level Innovative Health
   Talents
FX This work is supported, in part, by National Natural Science Foundation
   of China (81170787 & 81670786), Zhejiang Health and Family Planning
   Commission (2016KYA128) and Zhejiang Provincial Program for the
   Cultivation of High-Level Innovative Health Talents (2015).
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NR 24
TC 11
Z9 11
U1 0
U2 7
PU SPRINGER INDIA
PI NEW DELHI
PA 7TH FLOOR, VIJAYA BUILDING, 17, BARAKHAMBA ROAD, NEW DELHI, 110 001,
   INDIA
SN 0019-6061
EI 0974-7559
J9 INDIAN PEDIATR
JI Indian Pediatrics
PD OCT
PY 2017
VL 54
IS 10
BP 825
EP 829
DI 10.1007/s13312-017-1143-x
PG 5
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA FK7OZ
UT WOS:000413698100005
PM 28699612
DA 2025-06-11
ER

PT J
AU Shin, J
   Fukuhara, A
   Onodera, T
   Yokoyama, C
   Otsuki, M
   Shimomura, I
AF Shin, Jihoon
   Fukuhara, Atsunori
   Onodera, Toshiharu
   Yokoyama, Chieko
   Otsuki, Michio
   Shimomura, Iichiro
TI Regulation of Dipeptidyl Peptidase-4, its Substrate Chemokines, and
   Their Receptors in Adipose Tissue of ob/ob Mice
SO HORMONE AND METABOLIC RESEARCH
LA English
DT Article
DE DPP-4; obesity; differentiation; preadipocytes; chemokine
ID NATURAL-KILLER-CELLS; INSULIN-RESISTANCE; METABOLIC SYNDROME; ACTIVATED
   LYMPHOCYTES; OXIDATIVE STRESS; OBESITY; IV; EXPRESSION; CD26;
   ACCUMULATION
AB The physiological function of DPP-4 in proteolytic inactivation of incretins has been well established, however, there is limited information on the expression and the significance of DPP-4 in white adipose tissue with regard to obesity. The objective of the work was to reveal the expression and regulation of DPP-4 in adipocytes and compare the expression and activity of DPP-4 in white adipose tissue and several other organs such as the liver, muscle and kidney. We also investigated the gene expression levels of DPP-4 substrate chemokines, and their receptors in white adipose tissue. DPP-4 was mainly expressed in stromal vascular fraction (SVF), and downregulated in adipose tissue of ob/ob compared with C57BL6/J mice. Mimetic conditions of obese fat in vitro showed that differentiation of mouse primary preadipocytes into adipocytes was associated with marked downregulation of DPP-4 expression. Treatment with TNF-alpha or ROS even decreased DPP-4 expression in mouse primary adipocytes. Various DPP-4 substrate chemokines were expressed in white adipose tissue and regulated by obesity. The expression of receptors for DPP-4 substrate chemokines was markedly high and tightly regulated by obesity in white adipose tissue. Expression of DPP-4 was reduced in adipose tissues of ob/ob mice. Actions of several substrate chemokines might be potentiated by downregulation of DPP-4, synergistically with upregulation of chemokines and their receptors in adipose tissues of obese mice.
C1 [Shin, Jihoon; Fukuhara, Atsunori; Onodera, Toshiharu; Yokoyama, Chieko; Otsuki, Michio; Shimomura, Iichiro] Osaka Univ, Grad Sch Med, Dept Metab Med, 2-2,Yamadaoka, Suita, Osaka, Japan.
   [Shin, Jihoon; Shimomura, Iichiro] Osaka Univ, Grad Sch Frontier Biosci, 2-2,Yamadaoka, Suita, Osaka, Japan.
   [Yokoyama, Chieko] Kanagawa Inst Technol, Dept Nutr & Life Sci, Atsugi, Kanagawa, Japan.
C3 The University of Osaka; The University of Osaka; Kanagawa Institute
   Technology
RP Fukuhara, A (corresponding author), Osaka Univ, Grad Sch Med, Dept Metab Med, 2-2 B5 Yamadaoka, Osaka 5650871, Japan.
EM fukuhara@endmet.med.osaka-u.ac.jp
RI Onodera, Toshiharu/ABA-1806-2021; Shin, Jihoon/LDF-0118-2024; Fukuhara,
   Atsunori/A-9601-2018
OI Fukuhara, Atsunori/0000-0002-6289-3778; Onodera,
   Toshiharu/0000-0002-4439-0077; Shin, Jihoon/0000-0003-1294-0238
FU Osaka University Institute for Academic Initiatives; Boehringer
   Ingelheim; MEXT scholarship from the Japanese Government
FX We thank all the members of the Shimomura laboratory and the
   Interdisciplinary Program for Biomedical Sciences (IPBS) for the helpful
   discussion. This work was supported in part by the Osaka University
   Institute for Academic Initiatives, and grant from Boehringer Ingelheim.
   J.S. is supported by a MEXT scholarship from the Japanese Government.
   The funders had no role in study design, data collection and analysis,
   decision to publish, or preparation of the manuscript.
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NR 53
TC 8
Z9 9
U1 0
U2 4
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0018-5043
EI 1439-4286
J9 HORM METAB RES
JI Horm. Metab. Res.
PD MAY
PY 2017
VL 49
IS 5
BP 380
EP 387
DI 10.1055/s-0043-100115
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA EX2RH
UT WOS:000403073700009
PM 28222464
DA 2025-06-11
ER

PT J
AU Otero-Losada, M
   Llambi, HG
   Ottaviano, G
   Cao, G
   Müller, A
   Azzato, F
   Ambrosio, G
   Milei, J
AF Otero-Losada, Matilde
   Gomez Llambi, Hernan
   Ottaviano, Graciela
   Cao, Gabriel
   Mueller, Angelica
   Azzato, Francisco
   Ambrosio, Giuseppe
   Milei, Jose
TI Cardiorenal Involvement in Metabolic Syndrome Induced by Cola Drinking
   in Rats: Proinflammatory Cytokines and Impaired Antioxidative Protection
SO MEDIATORS OF INFLAMMATION
LA English
DT Article
ID COENZYME-Q(10); BLOCKER; LIPIDS
AB We report experimental evidence confirming renal histopathology, proinflammatory mediators, and oxidative metabolism induced by cola drinking. Male Wistar rats drank ad libitum regular cola (C, n = 12) or tap water (W, n = 12). Measures. Body weight, nutritional data, plasma glucose, cholesterol fractions, TG, urea, creatinine, coenzyme Q(10), SBP, and echocardiograms (0 mo and 6 mo). At 6 months euthanasia was performed. Kidneys were processed for histopathology and immunohistochemistry ( semiquantitative). Compared with W, C rats showed (I) overweight (+8%, p < 0.05), hyperglycemia (+11%, p < 0.05), hypertriglyceridemia (2-fold, p < 0.001), higher AIP (2-fold, p < 0.01), and lower Q(10) level (-55%, p < 0.05); (II) increased LV diastolic diameter (+9%, p < 0.05) and volume ( systolic +24%, p < 0.05), posterior wall thinning (-8%, p < 0.05), and larger cardiac output (+24%, p < 0.05); (III) glomerulosclerosis (+21%, p < 0.05), histopathology (+13%, p < 0.05), higher tubular expression of IL-6 (7-fold, p < 0.001), and TNF alpha (4-fold, p < 0.001). (IV) Correlations were found for LV dimensions with IL-6 (74%, p < 0.001) and TNF alpha (52%, p < 0.001) and fully abolished after TG and Q(10) control. Chronic cola drinking induced cardiac remodeling associated with increase in proinflammatory cytokines and renal damage. Hypertriglyceridemia and oxidative stress were key factors. Hypertriglyceridemic lipotoxicity in the context of defective antioxidant/anti-inflammatory protection due to low Q(10) level might play a key role in cardiorenal disorder induced by chronic cola drinking in rats.
C1 [Otero-Losada, Matilde; Gomez Llambi, Hernan; Ottaviano, Graciela; Cao, Gabriel; Mueller, Angelica; Azzato, Francisco; Milei, Jose] Univ Buenos Aires, Cardiol Res Inst, Natl Res Council, ININCA,CONICET, RA-1122 Buenos Aires, DF, Argentina.
   [Ambrosio, Giuseppe] Univ Perugia, Sch Med, I-06132 Perugia, Italy.
C3 University of Buenos Aires; Consejo Nacional de Investigaciones
   Cientificas y Tecnicas (CONICET); University of Perugia
RP Otero-Losada, M (corresponding author), Univ Buenos Aires, Cardiol Res Inst, Natl Res Council, ININCA,CONICET, RA-1122 Buenos Aires, DF, Argentina.
EM mol@fmed.uba.ar
RI Cao, Gabriel/LJL-8755-2024; Ambrosio, Giuseppe/JUV-2507-2023;
   Otero-Losada, Matilde/J-3050-2019
OI giuseppe, ambrosio/0000-0002-9677-980X
FU PIP CONICET [11220110100671]; UBACYT [20020130100858BA]
FX This study was supported by PIP CONICET 11220110100671 and UBACYT
   20020130100858BA.
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NR 28
TC 13
Z9 13
U1 0
U2 1
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 0962-9351
EI 1466-1861
J9 MEDIAT INFLAMM
JI Mediat. Inflamm.
PY 2016
VL 2016
AR 5613056
DI 10.1155/2016/5613056
PG 11
WC Cell Biology; Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Immunology
GA DO6OZ
UT WOS:000377904300001
PM 27340342
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Yracheta, JM
   Lanaspa, MA
   Le, MT
   Abdelmalak, MF
   Alfonso, J
   Sánchez-Lozada, LG
   Johnson, RJ
AF Yracheta, Joseph M.
   Lanaspa, Miguel A.
   Le, MyPhuong T.
   Abdelmalak, Manal F.
   Alfonso, Javier
   Sanchez-Lozada, Laura G.
   Johnson, Richard J.
TI Diabetes and Kidney Disease in American Indians: Potential Role of
   Sugar-Sweetened Beverages
SO MAYO CLINIC PROCEEDINGS
LA English
DT Article
ID STAGE RENAL-DISEASE; SERUM URIC-ACID; NUTRITION EXAMINATION SURVEY;
   COMMON GENETIC-VARIATION; 3RD NATIONAL-HEALTH; PHYSICAL-ACTIVITY;
   NATIVE-AMERICANS; ENERGY-EXPENDITURE; METABOLIC SYNDROME; OXIDATIVE
   STRESS
AB Since the early 20th century, a marked increase in obesity, diabetes, and chronic kidney disease has occurred in the American Indian population, especially the Pima Indians of the Southwest. Here, we review the current epidemic and attempt to identify remediable causes. A search was performed using PubMed and the search terms American Indian and obesity, American Indian and diabetes, American Indian and chronic kidney disease, and American Indian and sugar or fructose, Native American, Alaska Native, First Nations, Aboriginal, Amerind, and Amerindian for American Indian for articles linking American Indians with diabetes, obesity, chronic kidney disease, and sugar; additional references were identified in these publications traced to 1900 and articles were reviewed if they were directly discussing these topics. Multiple factors are involved in the increased risk for diabetes and kidney disease in the American Indian population, including poverty, overnutrition, poor health care, high intake of sugar, and genetic mechanisms. Genetic factors may be especially important in the Pima, as historical records suggest that this group was predisposed to obesity before exposure to Western culture and diet. Exposure to sugar-sweetened beverages may also be involved in the increased risk for chronic kidney disease. In these small populations in severe health crisis, we recommend further studies to investigate the role of excess added sugar, especially sugar-sweetened beverages, as a potentially remediable risk factor. (C) 2015 Mayo Foundation for Medical Education and Research
C1 [Yracheta, Joseph M.] Univ Washington, Sch Pharm, Dept Pharmaceut, Seattle, WA 98195 USA.
   [Lanaspa, Miguel A.; Le, MyPhuong T.; Alfonso, Javier; Johnson, Richard J.] Univ Colorado, Div Renal Dis & Hypertens, Aurora, CO USA.
   [Lanaspa, Miguel A.; Le, MyPhuong T.; Sanchez-Lozada, Laura G.; Johnson, Richard J.] Colorado Res Partners LLC, Aurora, CO USA.
   [Abdelmalak, Manal F.] Duke Univ, Div Gastroenterol & Hepatol, Durham, NC USA.
   [Sanchez-Lozada, Laura G.] Inst Nacl Cardiol Ignacio Chavez, Lab Renal Physiopathol, Mexico City, DF, Mexico.
   [Sanchez-Lozada, Laura G.] Inst Nacl Cardiol Ignacio Chavez, Dept Nephrol, Mexico City, DF, Mexico.
C3 University of Washington; University of Washington Seattle; University
   of Colorado System; University of Colorado Anschutz Medical Campus; Duke
   University; National Institute of Cardiology - Mexico; National
   Institute of Cardiology - Mexico
RP Yracheta, JM (corresponding author), Missouri Breaks Ind Res Inc, 118 S Willow St, Eagle Butte, SD 57625 USA.
EM joseph.yracheta@mbiri.com
RI Lanaspa, Miguel/AAO-4971-2020; Sanchez-Lozada, Laura/AAS-2104-2021
OI Sanchez-Lozada, Laura-Gabriela/0000-0003-0348-9617; Le,
   MyPhuong/0000-0002-1136-3419
FU W.K. Kellogg Foundation
FX The work was supported by a grant from the W.K. Kellogg Foundation.
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NR 148
TC 24
Z9 31
U1 0
U2 35
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0025-6196
EI 1942-5546
J9 MAYO CLIN PROC
JI Mayo Clin. Proc.
PD JUN
PY 2015
VL 90
IS 6
BP 813
EP 823
DI 10.1016/j.mayocp.2015.03.018
PG 11
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA CJ5UV
UT WOS:000355557900018
PM 26046414
OA Bronze
DA 2025-06-11
ER

PT J
AU Utzschneider, KM
   Largajolli, A
   Bertoldo, A
   Marcovina, S
   Nelson, JE
   Yeh, MM
   Kowdley, KV
   Kahn, SE
AF Utzschneider, Kristina M.
   Largajolli, Anna
   Bertoldo, Alessandra
   Marcovina, Santica
   Nelson, James E.
   Yeh, Matthew M.
   Kowdley, Kris V.
   Kahn, Steven E.
TI Serum ferritin is associated with non-alcoholic fatty liver disease and
   decreased B-cell function in non-diabetic men and women
SO JOURNAL OF DIABETES AND ITS COMPLICATIONS
LA English
DT Article
DE Insulin sensitivity; Ferritin; Insulin secretion in vivo; Fatty liver
ID TUMOR-NECROSIS-FACTOR; INSULIN-RESISTANCE; GLUCOSE-TOLERANCE;
   DIABETES-MELLITUS; MAJOR DETERMINANTS; METABOLIC SYNDROME; IRON
   DEPLETION; HUMAN OBESITY; SENSITIVITY; STRESS
AB Aims: We sought to determine whether NAFLD is associated with poorer beta-cell function and if any beta-cell dysfunction is associated with abnormal markers of iron or inflammation.
   Methods: This was a cross-sectional study of 15 non-diabetic adults with NAFLD and 15 non-diabetic age and BMI-matched controls. Insulin sensitivity was measured by isotope-labeled hyperinsulinemic-euglycemic clamps and beta-cell function by both oral (OGTT) and intravenous glucose tolerance tests. Liver and abdominal fat composition was evaluated by CT scan. Fasting serum levels of ferritin, transferrin-iron saturation, IL-6, TNF alpha and hsCRP were measured.
   Results: Compared to controls, subjects with NAFLD had lower hepatic and systemic insulin sensitivity and 12,cell function was decreased as measured by the oral disposition index. Fasting serum ferritin and transferrin-iron saturation were higher in NAFLD and were positively associated with liver fat. Serum ferritin was negatively associated with beta-cell function measured by both oral and intravenous tests, but was not associated with insulin sensitivity. IL-6, TNF alpha and hsCRP did not differ between groups and did not correlate with serum ferritin, liver fat or measures of beta-cell function.
   Conclusions: These findings support a potential pathophysiological link between iron metabolism, liver fat and diabetes risk. Published by Elsevier Inc.
C1 [Utzschneider, Kristina M.; Kahn, Steven E.] VA Puget Sound Hlth Care Syst, Dept Med, Div Endocrinol & Metab, Seattle, WA USA.
   [Utzschneider, Kristina M.; Kahn, Steven E.] Univ Washington, Dept Med, Div Metab Endocrinol & Nutr, Seattle, WA USA.
   [Largajolli, Anna; Bertoldo, Alessandra] Univ Padua, Padua, Italy.
   [Nelson, James E.; Kowdley, Kris V.] Virginia Mason Med Ctr, Inst Digest Dis, Seattle, WA 98101 USA.
   [Nelson, James E.; Kowdley, Kris V.] Benaroya Res Inst, Seattle, WA USA.
   [Yeh, Matthew M.] Univ Washington, Dept Pathol, Seattle, WA 98195 USA.
   [Kowdley, Kris V.] Univ Washington, Dept Med, Div Gastroenterol Hepatol, Seattle, WA USA.
   [Marcovina, Santica] Univ Washington, Dept Med, Seattle, WA USA.
   [Marcovina, Santica] Northwest Lipid Metab & Diabet Res Lab, Seattle, WA USA.
C3 US Department of Veterans Affairs; Veterans Health Administration (VHA);
   Vet Affairs Puget Sound Health Care System; University of Washington;
   University of Washington Seattle; University of Padua; Virginia Mason
   Medical Center; Benaroya Research Institute; University of Washington;
   University of Washington Seattle; University of Washington; University
   of Washington Seattle; University of Washington; University of
   Washington Seattle
RP Utzschneider, KM (corresponding author), VA Puget Sound Hlth Care Syst 151, Seattle, WA 98108 USA.
EM kutzschn@u.washington.edu
RI Kowdley, Kris/AAF-5202-2019
OI Utzschneider, Kristina/0000-0002-4924-196X; Kahn,
   Steven/0000-0001-7307-9002
FU United States Department of Veterans Affairs (Office of Research and
   Development Medical Research Service);  [UL1RR025014];  [P30DK017047]; 
   [P30DK035816];  [T32DK007247]
FX This work was supported by the United States Department of Veterans
   Affairs (Office of Research and Development Medical Research Service)
   and grant numbers UL1RR025014, P30DK017047, P30DK035816 and T32DK007247.
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NR 49
TC 28
Z9 29
U1 0
U2 12
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1056-8727
EI 1873-460X
J9 J DIABETES COMPLICAT
JI J. Diabetes Complications
PD MAR-APR
PY 2014
VL 28
IS 2
BP 177
EP 184
DI 10.1016/j.jdiacomp.2013.11.007
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA AD8VD
UT WOS:000333542900015
PM 24360972
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Xu, H
   Chen, YB
   Li, YX
   Xia, FZ
   Han, B
   Zhang, HX
   Zhai, HL
   Wu, H
   Li, Y
   Lu, YL
AF Xu Hui
   Chen Yanbo
   Li Yanxiang
   Xia Fangzhen
   Han Bing
   Zhang Huixin
   Zhai Hualing
   Wu Hui
   Li Ying
   Lu Yingli
TI Mitochondrial apoptosis of lymphocyte is induced in type 2 diabetes
SO CHINESE MEDICAL JOURNAL
LA English
DT Article
DE type 2 diabetes; lymphocyte; apoptosis
ID METABOLIC SYNDROME; OXIDATIVE STRESS; CELL-DEATH; ASSOCIATION; GLUCOSE
AB Background Lymphocyte function and homeostasis is associated with immune defence to infection. Apoptosis of lymphocytes might be a considerably important component which has an impact on immunity to infections in people with hyperglycemia. The aim of this study was to explore the mitochondrial apoptosis pathway of lymphocyte in diabetic patients.
   Methods Sixty patients with type 2 diabetes mellitus and fifty healthy volunteers were included in this study. Annexin V and propidiumiodide (PI) were joined in the isolated lymphocytes and the rate of lymphocyte apoptosis was calculated with flow cytometry. Observation of the lymphocytes was done using transmission electron microscopy; mitochondria had been extracted and then mitochondrial membrane potential (MMP) was detected to assess mitochondrial function; the mRNA level of Bcl-2, cytochrome c (Cyt-C), caspase-9 and caspase-3 were analyzed by real-time reverse transcription-polymerase chain reaction (RT-PCR).
   Results Apoptosis rate of lymphocyte was significantly higher in diabetic group than that in normal control group (P <0.05). Transmission electron microscopy showed lymphocyte shrinkage and breakage, chromatin condensation and less mitochondria; a fall in MMP levels was also evident; Bcl-2 concentration was reduced and the expressions of caspase-9, caspase-3 and Cyt-C were elevated (P <0.05) in diabetic patients.
   Conclusions The rate of lymphocyte apoptosis was significantly higher in type 2 diabetic patients than that in normal population. Mitochondrial apoptosis pathway may play a very important role in decreasing function of lymphocyte in diabetes.
C1 [Xu Hui; Li Yanxiang; Xia Fangzhen; Han Bing; Zhang Huixin; Zhai Hualing; Wu Hui; Li Ying; Lu Yingli] Shanghai Jiao Tong Univ, Sch Med, Shanghai Peoples Hosp 9, Endocrinol & Metab Res Inst, Shanghai 200011, Peoples R China.
   [Xu Hui; Li Yanxiang; Xia Fangzhen; Han Bing; Zhang Huixin; Zhai Hualing; Wu Hui; Li Ying; Lu Yingli] Shanghai Jiao Tong Univ, Sch Med, Shanghai Peoples Hosp 9, Dept Endocrinol & Metab, Shanghai 200011, Peoples R China.
   [Chen Yanbo] Shanghai Jiao Tong Univ, Sch Med, Shanghai Peoples Hosp 9, Dept Urol, Shanghai 200011, Peoples R China.
C3 Shanghai Jiao Tong University; Shanghai Jiao Tong University; Shanghai
   Jiao Tong University
RP Lu, YL (corresponding author), Shanghai Jiao Tong Univ, Sch Med, Shanghai Peoples Hosp 9, Endocrinol & Metab Res Inst, Shanghai 200011, Peoples R China.
EM luyingli2008@126.com
RI Zhang, Wei/HOF-7252-2023; Zhang, Bin/M-3689-2014; zhang,
   zhaofei/HTP-1374-2023; Chen, Yanbo/K-8163-2019
FU National Natural Science Foundation of China [81070677, 81270885];
   National Basic Research Program of China (973 Program) [2012CB524900];
   Science and Technology Commission of Shanghai Municipality [10JC1409000]
FX This study was supported by grants from the National Natural Science
   Foundation of China (Nos. 81070677 and 81270885), the National Basic
   Research Program of China (973 Program, No. 2012CB524900) and Science
   and Technology Commission of Shanghai Municipality (No. 10JC1409000).
CR [Anonymous], INT J CELL BIOL
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NR 25
TC 7
Z9 7
U1 1
U2 9
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0366-6999
J9 CHINESE MED J-PEKING
JI Chin. Med. J.
PD JAN 20
PY 2014
VL 127
IS 2
BP 213
EP 217
DI 10.3760/cma.j.issn.0366-6999.20131906
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 302LV
UT WOS:000330606900003
PM 24438606
OA gold
DA 2025-06-11
ER

PT J
AU Martos, R
   Valle, M
   Morales, R
   Cañete, R
   Gavilan, MI
   Sánchez-Margalet, V
AF Martos, R
   Valle, M
   Morales, R
   Cañete, R
   Gavilan, MI
   Sánchez-Margalet, V
TI Hyperhomocysteinemia correlates with insulin resistance and low-grade
   systemic inflammation in obese prepubertal children
SO METABOLISM-CLINICAL AND EXPERIMENTAL
LA English
DT Article
ID PLASMA HOMOCYSTEINE CONCENTRATIONS; METABOLIC CARDIOVASCULAR SYNDROME;
   OXIDANT STRESS; MISSING LINK; HYPERINSULINEMIA; INTERLEUKIN-6; LEPTIN;
   RISK; METHIONINE; EXPRESSION
AB Obesity is an independent risk factor for the development of cardiovascular disease frequently associated with hypertension, dyslipemia, diabetes, and insulin resistance. Higher homocysteine (Hcy) levels are observed in the hyperinsulinemic obese adults and suggest that Hey could play a role in the higher risk of cardiovascular disease in obesity. We analyzed total Hcy levels in obese prepubertal children and their possible association with both metabolic syndrome and various inflammatory biomarkers and leptin. We studied 43 obese children (aged 6-9 years) and an equal number of nonobese children, paired by age and sex. The obese subjects presented significantly elevated values for insulin (P =.003), C-reactive protein (P =.033), and leptin (P <.001). No significant differences were found in Hcy levels between the obese and nonobese children. However, Hey concentration was significantly higher in the hyperinsulinemic obese children than in the normoinsulinemic group (P =.002). Using multivariant regression analysis, in the obese group, corrected for age and sex, the homeostasis model assessment for insulin resistance (P partial -.001) and leptin (P partial =.02) are independent predictive factors for Hey. In the control group, corrected for age and sex, the homeostasis model assessment for insulin resistance (P partial -.005) and leptin (P partial =.031) also are independent predictive factor for Hcy. Increased plasma Hcy, particularly in hyperinsulinemic obese children, may be causally involved in the pathogenesis of atherosclerosis and/or cardiovascular disease, both of which are common in obesity. (c) 2005 Elsevier Inc. All rights reserved.
C1 Hlth Ctr Pozoblanco, Cordoba 14400, Spain.
   Valle Pedroches Hosp, Dept Clin Lab, Cordoba, Spain.
   Reina Sofia Univ, Dept Pediat, Cordoba, Spain.
   Hlth Ctr Penarroya, Cordoba, Spain.
   Virgen Macarena Univ Hosp, Dept Clin Biochem, Invest Unit, Seville, Spain.
C3 Hospital Universitario Virgen Macarena
RP Hlth Ctr Pozoblanco, Cordoba 14400, Spain.
EM rosariomartos96@yahoo.es
RI Sanchez-Margalet, Victor/AAB-9986-2021
OI Sanchez-Margalet, Victor/0000-0001-8638-8680; Morales
   Camacho/0000-0001-7179-0693
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NR 40
TC 59
Z9 65
U1 0
U2 2
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0026-0495
EI 1532-8600
J9 METABOLISM
JI Metab.-Clin. Exp.
PD JAN
PY 2006
VL 55
IS 1
BP 72
EP 77
DI 10.1016/j.metabol.2005.07.008
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 995KE
UT WOS:000234098400011
PM 16324922
DA 2025-06-11
ER

PT J
AU Zeng, YM
   Chen, YY
   Li, J
   Chen, L
AF Zeng, Yiming
   Chen, Yingying
   Li, Jie
   Chen, Liang
TI Nonlinear association between the serum uric acid-to-creatinine ratio
   and all cause mortality in patients with hypertension: a ten-year cohort
   study using the NHANES database
SO SCIENTIFIC REPORTS
LA English
DT Article
DE Hypertension; Uric acid-to-creatinine ratio; Mortality; Spline
   smoothing; Competing risk model
ID CHRONIC KIDNEY-DISEASE; METABOLIC SYNDROME; CARDIOVASCULAR-DISEASE;
   BLOOD-PRESSURE; RISK; OUTCOMES; HYPERURICEMIA; HYPOURICEMIA; MANAGEMENT;
   PREDICTOR
AB The serum uric acid-to-creatinine ratio (UCR) may be a simple method for assessing xanthine oxidase overactivation, which may contribute to an increase in serum uric acid production and oxidative stress. In this study, we investigated the nonlinear association between the UCR and long-term mortality in patients with hypertension. Data were acquired from the National Health and Nutrition Examination Survey database, and a total of 11,346 patients with hypertension were included. We explored the nonlinear link between the UCR and all-cause mortality via spline smoothing, threshold saturation, and log-likelihood ratio tests. The results were validated through a competing risk model. A nonlinear pattern emerged between the UCR and all-cause mortality in hypertensive patients, with an inflection point at 4.3. Below this point, an increased UCR was associated with a decreased mortality risk (OR = 0.80, 95% CI: 0.68-0.94, P = 0.008), whereas above this point, the risk increased (OR = 1.21, 95% CI: 1.07-1.36, P = 0.004). The competing risk model yielded similar findings for cardiovascular and chronic kidney disease-related deaths. In patients with hypertension, the UCR nonlinearly predicted all-cause mortality, with a notable inflection at 4.3. These findings suggest that the UCR is a valuable prognostic indicator for assessing long-term outcomes in patients with hypertension.
C1 [Zeng, Yiming; Chen, Liang] Dalian Med Univ, Affiliated Hosp 2, Dept Cardiol, Dalian, Peoples R China.
   [Chen, Yingying; Li, Jie] Shanghai Jiao Tong Univ, Ruijin Hainan Hosp, Hainan Boao Res Hosp, Dept Internal Med,Sch Med, Qionghai, Peoples R China.
C3 Dalian Medical University; Shanghai Jiao Tong University
RP Chen, L (corresponding author), Dalian Med Univ, Affiliated Hosp 2, Dept Cardiol, Dalian, Peoples R China.; Li, J (corresponding author), Shanghai Jiao Tong Univ, Ruijin Hainan Hosp, Hainan Boao Res Hosp, Dept Internal Med,Sch Med, Qionghai, Peoples R China.
EM lj15927931943@163.com; dyeyarrhythmia@163.com
RI Chen, Liang/LZI-1530-2025; Li, Jie/LZI-1634-2025
OI Jie, Li/0000-0001-8181-7140
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NR 57
TC 0
Z9 0
U1 2
U2 2
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD DEC 28
PY 2024
VL 14
IS 1
AR 31423
DI 10.1038/s41598-024-83034-x
PG 10
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA Q7O8Y
UT WOS:001386534800049
PM 39733075
OA gold
DA 2025-06-11
ER

PT J
AU Rekabi, A
   Ram, A
   Nazari, A
   Arefnezhad, R
   Rezaei-Tazangi, F
AF Rekabi, Atefe
   Ram, Arman
   Nazari, Ahmad
   Arefnezhad, Reza
   Rezaei-Tazangi, Fatemeh
TI Does crocin create new hope for the treatment of oral problems? A focus
   on periodontitis
SO MOLECULAR BIOLOGY REPORTS
LA English
DT Review
DE Periodontitis; Crocin; Herbal medicine; Pathogenesis
ID OXIDATIVE STRESS; SAFFRON; PROLIFERATION; PATHOGENESIS; INFLAMMATION;
   CONSTITUENT; TOXICITY; DISEASE
AB According to the World Health Organization (WHO) reports, oral health has an indispensable role in the maintenance of human public health. However, oral problems, especially periodontitis, are known as bad players in this issue. Periodontitis, as the most prevalent oral disease, is a type of chronic illness mediated by bacterial pathogens and immune system reactions, which is linked with the destruction of tooth-protecting tissues, such as alveolar bone and periodontal ligament. Periodontitis has a high prevalence (over 40% in the United States) and can be associated with other systemic ailments, for instance, arthritis, osteoporosis, metabolic syndrome, cancer, respiratory diseases, chronic kidney disease, and Alzheimer's disease. The common treatments for periodontitis are classified into invasive (surgical) and noninvasive (antibiotic therapy, scaling, and root planning) methods; however, these therapies have not reflected enough effectiveness for related patients. New documents inform the beneficial effects of plant-based compounds in healing various disorders, like periodontitis. In conjunction with this subject, it has been revealed that crocin, as an active component of saffron, regulates the balance between osteoclasts and osteoblasts and has a stroking role in the accumulation of the most common collagen in teeth and bone (type 1 collagen). Besides, this carotenoid compound possesses anti-inflammatory and anti-oxidative effects, which can be associated with the therapeutic processes of crocin in this oral disease. Hence, this narrative review study was performed to reflect the reparative/regenerative aspects of crocin agonist periodontitis.
C1 [Rekabi, Atefe] Ahvaz Jundishapur Univ Med Sci, Sch Dent, Dept Orthodont, Ahvaz, Iran.
   [Ram, Arman] Mashhad Univ Med Sci, Sch Dent, Mashhad, Iran.
   [Nazari, Ahmad] Univ Tehran Med Sci, Sch Med, Tehran, Iran.
   [Arefnezhad, Reza] Coenzyme R Res Inst, Tehran, Iran.
   [Arefnezhad, Reza] Shiraz Univ Med Sci, Student Res Comm, Shiraz, Iran.
   [Rezaei-Tazangi, Fatemeh] Fasa Univ Med Sci, Sch Med, Dept Anat, Fasa, Iran.
C3 Ahvaz Jundishapur University of Medical Sciences (AJUMS); Mashhad
   University of Medical Sciences; Tehran University of Medical Sciences;
   Shiraz University of Medical Science
RP Arefnezhad, R (corresponding author), Coenzyme R Res Inst, Tehran, Iran.; Arefnezhad, R (corresponding author), Shiraz Univ Med Sci, Student Res Comm, Shiraz, Iran.; Rezaei-Tazangi, F (corresponding author), Fasa Univ Med Sci, Sch Med, Dept Anat, Fasa, Iran.
EM Reza.aref1374@gmail.com; f.rezaei67@yahoo.com
RI Nazari, Ahmad/IAO-3105-2023; Arefnezhad, Reza/ABG-7243-2021;
   Rezaei-Tazangi, Fatemeh/ABE-2421-2021; Rekabi Bana, Atefe/HTS-4406-2023
OI Nazari, Ahmad/0009-0007-4712-3445; Rekabi Bana,
   Atefe/0000-0003-1173-4301
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NR 60
TC 4
Z9 4
U1 1
U2 9
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0301-4851
EI 1573-4978
J9 MOL BIOL REP
JI Mol. Biol. Rep.
PD DEC
PY 2024
VL 51
IS 1
AR 224
DI 10.1007/s11033-024-09209-x
PG 10
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA GH2V7
UT WOS:001151720400019
PM 38281199
DA 2025-06-11
ER

PT J
AU Mensah, EO
   Danyo, EK
   Asase, R
AF Mensah, Emmanuel O.
   Danyo, Emmanuel K.
   Asase, Richard, V
TI Exploring the effect of different diet types on ageing and age-related
   diseases
SO NUTRITION
LA English
DT Review
DE Lifespan; Ageing; Age-related diseases; Diet; Molecular pathways
ID PERSONALIZED DIET; OXIDATIVE STRESS; PALEOLITHIC NUTRITION;
   INSULIN-RESISTANCE; SENESCENT CELLS; GUT MICROBIOTA; IMMUNE-SYSTEM;
   LIFE-SPAN; INFLAMMATION; FUCOXANTHIN
AB In recent times, there has been growing interest in understanding the factors contributing to prolonged and healthy lifespans observed in specific populations, tribes, or countries. Factors such as environmental and dietary play significant roles in shaping the ageing process and are often the focus of inquiries seeking to unravel the secrets behind longevity. Among these factors, diet emerges as a primary determinant, capable of either promoting or mitigating the onset of age-related diseases that impact the ageing trajectory. This review examines the impact of various diet types on ageing and age-related conditions, including cardiovascular disease, cancer, neurodegenerative disorders, and metabolic syndrome. Different dietary patterns, such as the Mediterranean diet, the Japanese diet, vegetarian and vegan diets, as well as low-carbohydrate and ketogenic diets, are evaluated for their potential effects on longevity and health span. Each diet type is characterized by distinct nutritional profiles, emphasizing specific food groups, macronutrient compositions, and bioactive components, which may exert diverse effects on ageing processes and disease risk. Additionally, dietary factors such as calorie restriction, intermittent fasting, and dietary supplementation are explored for their potential anti-ageing and disease-modifying effects. Understanding the influence of various diet types on ageing and age-related diseases can inform personalized dietary recommendations and lifestyle interventions aimed at promoting healthy aging and mitigating age-associated morbidities. (c) 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.
C1 [Mensah, Emmanuel O.] ITMO Univ, Fac Ecotechnol, St Petersburg, Russia.
   [Danyo, Emmanuel K.; Asase, Richard, V] Ural Fed Univ, Inst Chem Engn, Ekaterinburg, Russia.
C3 ITMO University; Ural Federal University
RP Mensah, EO (corresponding author), ITMO Univ, Fac Ecotechnol, St Petersburg, Russia.
EM emmanuelofosu63@gmail.com
RI Mensah, Emmanuel Ofosu/JFL-1126-2023; Danyo, Emmanuel/HGC-5063-2022;
   Asase, Richard Vincent/JGC-8631-2023
OI Asase, Richard Vincent/0009-0002-7712-5955; Danyo, Emmanuel
   Kormla/0000-0003-2183-308X
FU Ministry of Science and Higher Education of the Russian Federation
FX The research funding from the Ministry of Science and Higher Education
   of the Russian Federation (Ural Federal University Program of
   Development within the Priority-2030 Program) is grate-fully
   acknowledged by two of the authors (RVA and EKD) .
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NR 158
TC 3
Z9 3
U1 10
U2 15
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0899-9007
EI 1873-1244
J9 NUTRITION
JI Nutrition
PD JAN
PY 2025
VL 129
AR 112596
DI 10.1016/j.nut.2024.112596
EA NOV 2024
PG 15
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA L4F6R
UT WOS:001350297600001
PM 39488864
DA 2025-06-11
ER

PT J
AU Mastorci, F
   Ait-Ali, L
   Festa, P
   Martini, M
   Gagliardi, L
   Calabri, G
   La Marca, G
   Trivellini, G
   Casu, A
   Dalmiani, S
   Marcheschi, P
   Celi, S
   Pingitore, A
AF Mastorci, Francesca
   Ait-Ali, Lamia
   Festa, Pierluigi
   Martini, Marco
   Gagliardi, Luigi
   Calabri, Giovanni
   La Marca, Giancarlo
   Trivellini, Gabriele
   Casu, Anselmo
   Dalmiani, Stefano
   Marcheschi, Paolo
   Celi, Simona
   Pingitore, Alessandro
TI A New Web Score to Predict Health Status in Paediatric Patients with
   Chronic Diseases: Design and Development of the PENSAMI Study
SO CHILDREN-BASEL
LA English
DT Article
DE comprehensive integrated health algorithm; ontology; chronic
   degenerative diseases; paediatric patients; quality of life; precision
   medicine
ID QUALITY-OF-LIFE; CHILDREN; ADOLESCENTS; CHILDHOOD; CONSEQUENCES; RISK
AB Paediatric chronic diseases (CD) are characterised by their ongoing duration and the fact that they are often managed throughout the lifespan, with the need to adjust lifestyle and expectations with the limitations coming from the CD. The aim of the PENSAMI study is to not only cure the disease, but to also care for the person from a clinical and psychosocial perspective. Data will be collected from 150 paediatric patients affected by heart disease, diabetes, and asthma admitted during in-hospital stay or outpatient visits, and from 200 healthy control subjects. The protocol will consist of two phases. The first one will aim at elaborating the predictive model by detecting (clinical, anthropometric at birth, environmental, lifestyle, social context, emotional state, and mental abilities) in order to develop a model predictive of the events considered: (1) re-hospitalisation; (2) severity and progression of the disease; (3) adherence to therapy; (4) HRQoL; (5) obesity and metabolic syndrome; (6) illness-stress related; (7) school drop-out; (8) school performance. The second one will address validating the previous predictive model. This model will aim to: (1) understand, prevent, and halt the progression of childhood CD; (2) develop new and improved diagnostic tools; (3) pave the way for innovative treatments and additional therapies to traditional clinical practice; and (4) create truly personalised therapeutic and preventive strategies in various sectors, such as cardiology, diabetes, and respiratory diseases.
C1 [Mastorci, Francesca; Ait-Ali, Lamia; Trivellini, Gabriele; Casu, Anselmo; Pingitore, Alessandro] Consiglio Nazl Ric Area Ric Pisa CNR, Inst Clin Physiol, I-56124 Pisa, Italy.
   [Festa, Pierluigi; Dalmiani, Stefano; Marcheschi, Paolo; Celi, Simona] Fdn G Monasterio, I-56226 Pisa, Regione Toscana, Italy.
   [Martini, Marco] San Donato Hosp, Pediat Allergol & Pulmonol, I-52100 Arezzo, Italy.
   [Gagliardi, Luigi] Usl Nord Ovest Toscana, Pediat Unit, I-55041 Viareggio, Italy.
   [Calabri, Giovanni] Azienda Osped Univ Meyer, Unit Pediat Cardiol, I-50139 Florence, Italy.
   [La Marca, Giancarlo] Meyer Childrens Hosp, Newborn Screening Clin Chem & Pharmacol Lab, I-50139 Florence, Italy.
C3 IRCCS Policlinico San Donato; University of Florence; Azienda
   Ospedaliera Universitaria (AOU) MEYER; University of Florence; Azienda
   Ospedaliera Universitaria (AOU) MEYER
RP Pingitore, A (corresponding author), Consiglio Nazl Ric Area Ric Pisa CNR, Inst Clin Physiol, I-56124 Pisa, Italy.
EM mastorcif@ifc.cnr.it; aitlamia@ifc.cnr.it; gigifesta@ftgm.it;
   marco.martini@uslsudest.toscana.it;
   luigi.gagliardi@uslnordovest.toscana.it; giovanni.calabri@meyer.it;
   giancarlo.lamarca@meyer.it; gabriele.trivellini@ifc.cnr.it;
   webmaster@easywebmaster.eu; dalmiani@ftgm.it; paolo.marcheschi@ftgm.it;
   celi77@ftgm.it; pingi@ifc.cnr.it
RI Pingitore, Alessandro/K-1843-2018; la Marca, Giancarlo/A-2853-2013;
   Lamia, Ait Ali/AAB-2420-2021; Cortimiglia, Martina/AAA-2753-2019; Celi,
   Simona/J-7841-2016; Ait Ali, Lamia/F-8116-2015; Gagliardi,
   Luigi/K-2144-2016
OI Mastorci, Francesca/0000-0002-9415-3715; Celi,
   Simona/0000-0002-7832-0122; Marcheschi, Paolo/0000-0001-6682-705X; Ait
   Ali, Lamia/0000-0003-1672-5308; Dalmiani, Stefano/0000-0002-2010-9164;
   Calabri, Giovanni Battista/0000-0002-7256-3916; la marca,
   giancarlo/0000-0003-3319-7260; Gagliardi, Luigi/0000-0001-6074-8975
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NR 33
TC 1
Z9 1
U1 0
U2 0
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2227-9067
J9 CHILDREN-BASEL
JI Children-Basel
PD DEC
PY 2021
VL 8
IS 12
AR 1094
DI 10.3390/children8121094
PG 9
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Pediatrics
GA XX4BV
UT WOS:000736244200001
PM 34943290
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Mauri, E
   Gori, M
   Giannitelli, SM
   Zancla, A
   Mozetic, P
   Abbruzzese, F
   Merendino, N
   Gigli, G
   Rossi, F
   Trombetta, M
   Rainer, A
AF Mauri, Emanuele
   Gori, Manuele
   Giannitelli, Sara Maria
   Zancla, Andrea
   Mozetic, Pamela
   Abbruzzese, Franca
   Merendino, Nicolo
   Gigli, Giuseppe
   Rossi, Filippo
   Trombetta, Marcella
   Rainer, Alberto
TI Nano-encapsulation of hydroxytyrosol into formulated nanogels improves
   therapeutic effects against hepatic steatosis: An in vitro study
SO MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL
   APPLICATIONS
LA English
DT Article
DE Nanoencapsulation; Nanogel; Drug delivery; NAFLD; Hydroxytyrosol
ID NONALCOHOLIC FATTY LIVER; CERIUM OXIDE NANOPARTICLES; DRUG-DELIVERY;
   METABOLIC SYNDROME; OLIVE OIL; CHOLESTEROL; DYSFUNCTION; MODULATION;
   MANAGEMENT; PHENOLS
AB Nanomaterials hold promise as a straightforward approach for enhancing the performance of bioactive compounds in several healthcare scenarios. Indeed, nanoencapsulation represents a valuable strategy to preserve the bioactives, maximizing their bioavailability. Here, a nanoencapsulation strategy for the treatment of nonalcoholic fatty liver disease (NAFLD) is presented. NAFLD represents the most common chronic liver disease in Western societies, and still lacks an effective therapy. Hydroxytyrosol (HT), a naturally occurring polyphenol, has been shown to protect against hepatic steatosis through its lipid-lowering, antioxidant and anti-inflammatory activities. However, the efficient delivery of HT to hepatocytes remains a crucial aspect: the design of smart nanogels appears as a promising tool to promote its intracellular uptake. In this paper, we disclose the synthesis of nanogel systems based on polyethylene glycol and polyethyleneimine which have been tested in an in vitro model of hepatic steatosis at two different concentrations (0.1 mg/mL and 0.5 mg/mL), taking advantage of high-content analysis tools. The proposed HT-loaded nanoscaffolds are non-toxic to cells, and their administration showed a significant decrease in the intracellular triglyceride levels, restoring cell viability and outperforming the results achievable with HT in its non-encapsulated form. Moreover, nanogels do not induce oxidative stress, thus demonstrating their biosafety. Overall, the formulated nanogel system achieves superior performance compared to conventional drug administration routes and hence represents a promising strategy for the management of NAFLD.
C1 [Mauri, Emanuele; Gori, Manuele; Giannitelli, Sara Maria; Zancla, Andrea; Abbruzzese, Franca; Trombetta, Marcella; Rainer, Alberto] Univ Campus Biomed Roma, Dept Engn, Via Alvaro Portillo 21, I-00128 Rome, Italy.
   [Gori, Manuele] Natl Res Council CNR, Inst Biochem & Cell Biol IBBC, Via E Ramarini 32, I-00015 Rome, Italy.
   [Zancla, Andrea] Univ Roma Tre, Dept Engn, Via Vito Volterra 62, I-00146 Rome, Italy.
   [Mozetic, Pamela; Gigli, Giuseppe; Rainer, Alberto] Natl Res Council CNR, Inst Nanotechnol NANOTEC, Via Monteroni, I-73100 Lecce, Italy.
   [Merendino, Nicolo] Univ Tuscia, Dept Ecol & Biol, I-01100 Viterbo, Italy.
   [Gigli, Giuseppe] Univ Salento, Dept Math & Phys Ennio De Giorgi, Via Arnesano, I-73100 Lecce, Italy.
   [Rossi, Filippo] Politecn Milan, Dept Chem Mat & Chem Engn G Natta, Via L Mancinelli 7, I-20131 Milan, Italy.
C3 University Campus Bio-Medico - Rome Italy; Consiglio Nazionale delle
   Ricerche (CNR); Istituto di Biochimica e Biologia Cellulare (IBBC-CNR);
   Roma Tre University; Consiglio Nazionale delle Ricerche (CNR); Istituto
   di Nanotecnologia (NANOTEC-CNR); Tuscia University; University of
   Salento; Polytechnic University of Milan
RP Rainer, A (corresponding author), Univ Campus Biomed Roma, Dept Engn, Via Alvaro Portillo 21, I-00128 Rome, Italy.
EM a.rainer@unicampus.it
RI Rainer, Alberto/G-8588-2011; Gori, Manuele/AAE-7052-2021; Giannitelli,
   Sara/AAC-1819-2019; Merendino, Nicolò/N-7661-2013; Mozetic,
   Pamela/AAE-3850-2021; Mele, Giuseppe/N-9765-2015; Rossi,
   Filippo/D-3679-2013; Zancla, Andrea/AAI-9319-2020; Gori,
   Manuele/J-9184-2016; Mauri, Emanuele/B-7674-2018
OI Gori, Manuele/0000-0001-6957-2718; Mauri, Emanuele/0000-0002-6203-8405
FU "Tecnopolo per la medicina di precisione" (TecnoMed Puglia) - Regione
   Puglia: DGR [2117, CUP: B84I18000540002]; "Tecnopolo di Nanotecnologia e
   Fotonica per la Medicina di Precisione" (TECNOMED) -FISR/MIURCNR:
   delibera CIPE [3449, CUP: B83B17000010001]; Associazione Cuore della
   Puglia [153/2021]
FX P.M., G.G. and A.R. are thankful to "Tecnopolo per la medicina di
   precisione" (TecnoMed Puglia) - Regione Puglia: DGR n.2117 dated
   21/11/2018, CUP: B84I18000540002 and "Tecnopolo di Nanotecnologia e
   Fotonica per la Medicina di Precisione" (TECNOMED) -FISR/MIURCNR:
   delibera CIPE n.3449 dated 07/08/2017, CUP: B83B17000010001. CNR-NANOTEC
   acknowledges the collaboration with "Associazione Cuore della Puglia"
   (Prot. 153/2021).
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NR 61
TC 12
Z9 12
U1 1
U2 26
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0928-4931
EI 1873-0191
J9 MAT SCI ENG C-MATER
JI Mater. Sci. Eng. C-Mater. Biol. Appl.
PD MAY
PY 2021
VL 124
AR 112080
DI 10.1016/j.msec.2021.112080
EA MAR 2021
PG 11
WC Materials Science, Biomaterials
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Materials Science
GA RY1SB
UT WOS:000647696000001
PM 33947572
DA 2025-06-11
ER

PT J
AU Elisha, IL
   Viljoen, A
AF Elisha, Ishaku Leo
   Viljoen, Alvaro
TI Trends in Rooibos Tea (Aspalathus linearis) research (1994-2018):
   A scientometric assessment
SO SOUTH AFRICAN JOURNAL OF BOTANY
LA English
DT Article
DE Rooibos tea; Aspalathus linearis; Herbal tea; Bibliometrics;
   Scientometrics; Scopus; VOSviewer
ID CYCLOPIA SPP.; HONEYBUSH; NOTHOFAGIN; EXTRACTS
AB This bibliometric assessment aimed to gain insight into the publication landscape over a 25-year period on one of South Africa's most coveted indigenous plants, Aspalathus linearis, known in commerce as rooibos tea. Despite the growing global market, and acceptance as a refreshing and health-promoting tea, scientific publications on rooibos, have not been subjected to scientometric analyses. A total of 421 relevant documents spanning the period 1994-2018 as indexed in the Scopus database were considered using VOSviewer. The global publication contribution on rooibos tea shows an average annual growth rate of 27.2%, and citation impact averaged 30 per publication. South African authors dominated the research landscape, contributing to approximately 60% of the total publication output. Prominent research themes include oxidative stress and inflammatory process mitigation using rooibos tea extracts, agronomy and fair trade in the rooibos tea industry, metabolic syndrome research, antioxidant activity, toxicity, quality control of rooibos tea and formulated products. More recently, a research focus has developed around bioavailability evaluation of rooibos tea components, green synthesis and nanoparticle formulations with the aim of improving the efficacy and potency of rooibos tea in the treatment of Type 2 Diabetes. We propose that research attention should be devoted to the mechanistic action of rooibos metabolites in mitigation of infectious diseases, diabetes, cardiovascular diseases and obesity which will inevitably lay the foundation for clinical studies to proceed. (C) 2020 SAAB. Published by Elsevier B.V. All rights reserved.
C1 [Elisha, Ishaku Leo; Viljoen, Alvaro] Tshwane Univ Technol, Fac Sci, Dept Pharmaceut Sci, Private Bag X680, ZA-0001 Pretoria, South Africa.
   [Viljoen, Alvaro] Tshwane Univ Technol, Fac Sci, SAMRC Herbal Drugs Res Unit, Private Bag X680, ZA-0001 Pretoria, South Africa.
   [Elisha, Ishaku Leo] Natl Vet Res Inst, Biochem Div, Drug Dev Sect, PMB 01, Vom, Vom Plateau Sta, Nigeria.
C3 Tshwane University of Technology; Tshwane University of Technology
RP Viljoen, A (corresponding author), Tshwane Univ Technol, Fac Sci, Dept Pharmaceut Sci, Private Bag X680, ZA-0001 Pretoria, South Africa.; Viljoen, A (corresponding author), Tshwane Univ Technol, Fac Sci, SAMRC Herbal Drugs Res Unit, Private Bag X680, ZA-0001 Pretoria, South Africa.
EM viljoenam@tut.ac.za
RI ELISHA, ISHAKU/KHE-4118-2024
FU Tshwane University of Technology, National Research Foundation (DST-NRF
   SARChI program); South African Medical Research Council
FX Funding has been provided by the Tshwane University of Technology,
   National Research Foundation (DST-NRF SARChI program) and the South
   African Medical Research Council.
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NR 47
TC 13
Z9 13
U1 7
U2 38
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0254-6299
EI 1727-9321
J9 S AFR J BOT
JI S. Afr. J. Bot.
PD MAR
PY 2021
VL 137
BP 159
EP 170
DI 10.1016/j.sajb.2020.10.004
PG 12
WC Plant Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences
GA RT3OO
UT WOS:000644371800016
OA hybrid
DA 2025-06-11
ER

PT J
AU Prasun, P
   Ginevic, I
   Oishi, K
AF Prasun, Pankaj
   Ginevic, Ilona
   Oishi, Kimihiko
TI Mitochondrial dysfunction in nonalcoholic fatty liver disease and
   alcohol related liver disease
SO TRANSLATIONAL GASTROENTEROLOGY AND HEPATOLOGY
LA English
DT Review
DE Mitochondria; nonalcoholic fatty liver disease (NAFLD); nonalcoholic
   steatohepatitis (NASH); metabolic syndrome; mitochondrial dysfunction
ID ACTIVATED PROTEIN-KINASE; HUMAN SKELETAL-MUSCLE; TRANSCRIPTIONAL
   CONTROL; GENETIC PREDISPOSITION; MOLECULAR-MECHANISMS; DNA;
   STEATOHEPATITIS; INFLAMMATION; GUT; PATHOGENESIS
AB Fatty liver disease constitutes a spectrum of liver diseases which begin with simple steatosis and may progress to advance stages of steatohepatitis, cirrhosis, and hepatocellular carcinoma (HCC). The two main etiologies are-alcohol related fatty liver disease (ALD) and nonalcoholic fatty liver disease (NAFLD). NAFLD is a global health epidemic strongly associated with modern dietary habits and life-style. It is the second most common cause of chronic liver disease in the US after chronic hepatitis C virus (HCV) infection. Approximately 100 million people are affected with this condition in the US alone. Excessive intakes of calories, saturated fat and refined carbohydrates, and sedentary life style have led to explosion of this health epidemic in developing nations as well. ALD is the third most common cause of chronic liver disease in the US. Even though the predominant trigger for onset of steatosis is different in these two conditions, they share common themes in progression from steatosis to the advance stages. Oxidative stress (OS) is considered a very significant contributor to hepatocyte injury in these conditions. Mitochondrial dysfunction contributes to this OS. Role of mitochondrial dysfunction in pathogenesis of fatty liver diseases is emerging but far from completely understood. A better understanding is essential for more effective preventive and therapeutic interventions. Here, we discuss the pathogenesis and therapeutic approaches of NAFLD and ALD from a mitochondrial perspective.
C1 [Prasun, Pankaj; Ginevic, Ilona; Oishi, Kimihiko] Icahn Sch Med Mt Sinai, Dept Genet & Genom Sci, One Gustave L Levy Pl Box 1497, New York, NY 10029 USA.
C3 Icahn School of Medicine at Mount Sinai
RP Prasun, P (corresponding author), Icahn Sch Med Mt Sinai, Dept Genet & Genom Sci, One Gustave L Levy Pl Box 1497, New York, NY 10029 USA.
EM Pankaj.Prasun@mssm.edu
OI Oishi, Kimihiko/0000-0001-9446-8912
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NR 107
TC 70
Z9 74
U1 3
U2 25
PU AME PUBLISHING COMPANY
PI SHATIN
PA FLAT-RM C 16F, KINGS WING PLAZA 1, NO 3 KWAN ST, SHATIN, HONG KONG
   00000, PEOPLES R CHINA
EI 2415-1289
J9 TRANSL GASTROENT HEP
JI Transl. Gastroenterol. Hepatol.
PD JAN
PY 2021
VL 6
AR 4
DI 10.21037/tgh-20-125
PG 14
WC Gastroenterology & Hepatology
WE Emerging Sources Citation Index (ESCI)
SC Gastroenterology & Hepatology
GA OX1WE
UT WOS:000593363000004
PM 33437892
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Xie, H
   Yepuri, N
   Meng, QH
   Dhawan, R
   Leech, CA
   Chepurny, OG
   Holz, GG
   Cooney, RN
AF Xie, Han
   Yepuri, Natesh
   Meng, Qinghe
   Dhawan, Ravi
   Leech, Colin A.
   Chepurny, Oleg G.
   Holz, George G.
   Cooney, Robert N.
TI Therapeutic potential of α7 nicotinic acetylcholine receptor agonists to
   combat obesity, diabetes, and inflammation
SO REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
LA English
DT Article
DE alpha 7nAChR; Cholinergic anti-inflammatory reflex; Obesity; Diabetes;
   GLP-1; PYY
ID DIET-INDUCED OBESITY; VAGUS NERVE-STIMULATION; BODY-WEIGHT; FOOD-INTAKE;
   PARTIAL DUPLICATION; COGNITIVE DEFICITS; INSULIN-SECRETION;
   MOLECULAR-CLONING; CROSS-TALK; IN-VITRO
AB The cholinergic anti-inflammatory reflex (CAIR) represents an important homeostatic regulatory mechanism for sensing and controlling the body's response to inflammatory stimuli. Vagovagal reflexes are an integral component of CAIR whose anti-inflammatory effects are mediated by acetylcholine (ACh) acting at alpha 7 nicotinic acetylcholine receptors (alpha 7nAChR) located on cells of the immune system. Recently, it is appreciated that CAIR and alpha 7nAChR also participate in the control of metabolic homeostasis. This has led to the understanding that defective vagovagal reflex circuitry underlying CAIR might explain the coexistence of obesity, diabetes, and inflammation in the metabolic syndrome. Thus, there is renewed interest in the alpha 7nAChR that mediates CAIR, particularly from the standpoint of therapeutics. Of special note is the recent finding that alpha 7nAChR agonist GTS-21 acts at L-cells of the distal intestine to stimulate the release of two glucoregulatory and anorexigenic hormones: glucagon-like peptide-1 (GLP-1) and peptide YY (PYY). Furthermore, alpha 7nAChR agonist PNU 282987 exerts trophic factor-like actions to support pancreatic beta-cell survival under conditions of stress resembling diabetes. This review provides an overview of alpha 7nAChR function as it pertains to CAIR, vagovagal reflexes, and metabolic homeostasis. We also consider the possible usefulness of alpha 7nAChR agonists for treatment of obesity, diabetes, and inflammation.
C1 [Xie, Han; Yepuri, Natesh; Meng, Qinghe; Dhawan, Ravi; Leech, Colin A.; Cooney, Robert N.] SUNY Upstate Med Univ, Dept Surg, 750 E Adams St,Suite 8141, Syracuse, NY 13210 USA.
   [Chepurny, Oleg G.; Holz, George G.] SUNY Upstate Med Univ, Dept Med, Syracuse, NY 13210 USA.
C3 State University of New York (SUNY) System; State University of New York
   (SUNY) Upstate Medical Center; State University of New York (SUNY)
   System; State University of New York (SUNY) Upstate Medical Center
RP Cooney, RN (corresponding author), SUNY Upstate Med Univ, Dept Surg, 750 E Adams St,Suite 8141, Syracuse, NY 13210 USA.
EM cooneyr@upstate.edu
RI Holz, George/A-3386-2012
OI Dhawan, Ravi/0000-0002-2544-341X; Xie, Han/0009-0009-0463-4944; Holz,
   George/0000-0002-1781-3580; Cooney, Robert/0000-0002-8901-3638
FU  [1R01DK122332];  [5R01DK069575]
FX Supported in part by 1R01DK122332 (GGH, RNC) and 5R01DK069575 (GGH).
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NR 173
TC 30
Z9 35
U1 0
U2 5
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1389-9155
EI 1573-2606
J9 REV ENDOCR METAB DIS
JI Rev. Endocr. Metab. Disord.
PD DEC
PY 2020
VL 21
IS 4
BP 431
EP 447
DI 10.1007/s11154-020-09584-3
EA AUG 2020
PG 17
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA NZ9BZ
UT WOS:000563152900001
PM 32851581
OA Green Accepted
DA 2025-06-11
ER

PT J
AU De Leo, M
   Piragine, E
   Pirone, A
   Braca, A
   Pistelli, L
   Calderone, V
   Miragliotta, V
   Testai, L
AF De Leo, Marinella
   Piragine, Eugenia
   Pirone, Andrea
   Braca, Alessandra
   Pistelli, Luisa
   Calderone, Vincenzo
   Miragliotta, Vincenzo
   Testai, Lara
TI Protective Effects of Bergamot ( Citrus bergamia Risso & Poiteau)
   Juice in Rats Fed with High-Fat Diet
SO PLANTA MEDICA
LA English
DT Article
DE Citrus bergamia; Rutaceae; cardiovascular risk; inflammation; Citrus;
   flavonoids
ID OBESITY; INFLAMMATION; FLAVONOIDS; LIMONOIDS
AB The bergamot ( Citrus bergamia Risso & Poiteau), a small tree cultivated along the Ionian coast of the Calabria region in Southern Italy, is an ancient plant used for the production of essential oil from fruit peel, but recently evaluated also for the high content of phenolics in the fruit pulp. Indeed, the juice is rich in glycosylated flavone and flavanones, showing a wide range of pharmacological activities. Noteworthy preclinical and clinical studies reported that bergamot juice is effective in reducing plasma lipids. The aim of this study was to evaluate the beneficial effects of a C. bergamia juice using an experimental animal model of metabolic syndrome and cardiovascular risk in vivo . A significant reduction of both triglyceride levels and cardiovascular risk was observed in animals fed with a high-fat diet and bergamot juice. Daily oral treatment with bergamot juice significantly limits a high-fat-induced increase in body, visceral adipose tissue, liver, and heart weight. In addition, C. bergamia juice showed protective effects on hepatic steatosis, probably due to the reduction of oxidative stress and inflammation. Chemical constituents of administered bergamot juice, investigated by means of liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI-MS/MS) analyses were represented by a wide range of flavonoids, with neohesperidin, neoeriocitrin, and naringin being the most abundant flavonoids according to previous studies. Furthermore, a considerable amount of brutieridin, a flavanone O -glycoside having a 3-hydroxy-3-methyl-glutaryl residue, was observed.
C1 [De Leo, Marinella; Piragine, Eugenia; Braca, Alessandra; Pistelli, Luisa; Calderone, Vincenzo; Testai, Lara] Univ Pisa, Dipartimento Farm, Via Bonanno 33, I-56126 Pisa, Italy.
   [De Leo, Marinella; Braca, Alessandra; Pistelli, Luisa; Calderone, Vincenzo; Testai, Lara] Univ Pisa, Ctr Interdipartimentale Ric Nutraceut & Alimentaz, Pisa, Italy.
   [Pirone, Andrea; Calderone, Vincenzo; Miragliotta, Vincenzo] Univ Pisa, Dipartimento Sci Vet, Pisa, Italy.
C3 University of Pisa; University of Pisa; University of Pisa
RP Braca, A (corresponding author), Univ Pisa, Dipartimento Farm, Via Bonanno 33, I-56126 Pisa, Italy.
EM alessandra.braca@unipi.it
RI PIRONE, ANDREA/S-7228-2019; Piragine, Eugenia/ISB-8787-2023; CALDERONE,
   VINCENZO/L-9288-2015; Miragliotta, Vincenzo/K-7361-2015
OI testai, lara/0000-0003-2431-6248; Piragine, Eugenia/0000-0001-6558-3065;
   CALDERONE, VINCENZO/0000-0002-1441-5421; Miragliotta,
   Vincenzo/0000-0001-7896-5695
FU University of Pisa [PRA_2017_26]
FX This work was supported by the University of Pisa (Grant no.
   PRA_2017_26).
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NR 41
TC 19
Z9 19
U1 0
U2 29
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0032-0943
EI 1439-0221
J9 PLANTA MED
JI Planta Med.
PD FEB
PY 2020
VL 86
IS 3
BP 180
EP 189
DI 10.1055/a-1070-9325
PG 10
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA KM9FI
UT WOS:000514446600002
PM 31860116
DA 2025-06-11
ER

PT J
AU Jin, D
   Sun, J
   Huang, J
   Yu, XL
   Yu, A
   He, YD
   Li, Q
   Yang, ZQ
AF Jin, Dan
   Sun, Jun
   Huang, Jing
   Yu, Xiaoling
   Yu, An
   He, Yiduo
   Li, Qiang
   Yang, Zaiqing
TI Peroxisome proliferator-activated receptor γ enhances adiponectin
   secretion via up-regulating DsbA-L expression
SO MOLECULAR AND CELLULAR ENDOCRINOLOGY
LA English
DT Article
DE Adiponectin; Secretion; DsbA-L; PPAR gamma
ID MEDIATED PROTEIN RETENTION; GLUTATHIONE-S-TRANSFERASE;
   ENDOPLASMIC-RETICULUM; DOWN-REGULATION; INSULIN-RESISTANCE; METABOLIC
   SYNDROME; ENDOCRINE ORGAN; ADIPOSE-TISSUE; MULTIMERIZATION; STRESS
AB Disulfide-bond A oxidoreductase like-protein (DsbA-L) was identified as a molecular chaperone facilitating the assembly and secretion of adiponectin, an adipokine with multiple beneficial effects. In obesity the level of DsbA-L is reduced with a concomitant decrease of the circulating adiponectin level, especially of the high molecular weight form (HMW). Both rodent and human studies have shown that the nuclear receptor peroxisome proliferator-activated receptor (PPAR)-gamma agonists increase adiponectin levels in serum by activating PPAR gamma, which up-regulates critical endoplasmic reticulum (ER) chaperones thus facilitating protein folding. As shown in the present study, overexpression of PPAR gamma in human embryonic kidney (HEK) 293 cells elicited the cellular release of HMW adiponectin. PPAR gamma enhanced expression of DsbA-L by binding directly to peroxisome proliferator response element (PPRE) site within the DsbA-L promoter. Conversely, in differentiated 3T3-L1 cells, PPAR gamma knockdown resulted in decreased expression of Adiponectin, DsbA-L and ERp44. DsbA-L expression increased after PPAR gamma agonist treatment and decreased upon treatment with PPAR gamma antagonist in 3T3-L1 adipocytes. DsbA-L deficiency in differentiated 3T3-L1 cells impaired the secretion of adiponectin. We therefore propose that DsbA-L plays an important role in facilitating HMW adiponectin formation and release from cells under the regulation of PPAR gamma. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
C1 [Jin, Dan; Sun, Jun; Huang, Jing; Yu, Xiaoling; Yu, An; He, Yiduo; Li, Qiang; Yang, Zaiqing] Huazhong Agr Univ, Coll Life Sci & Technol, Key Lab Agr Anim Genet Breeding & Reprod, Minist Educ, Wuhan 430070, Peoples R China.
C3 Huazhong Agricultural University; Ministry of Education - China
RP Yang, ZQ (corresponding author), Huazhong Agr Univ, Coll Life Sci & Technol, Wuhan 430070, Peoples R China.
EM yangzq@mail.hzau.edu.cn
FU National key Basic Research Program of China [2012CB124702]; 948 Program
   [2013-S15]; Specialized Research Fund for the Doctoral Program of Higher
   Education [20110146130002]; Program of National Natural Science
   Foundation of China [31172093, 30970356]; National Science Foundation
   for Fostering Talents in Basic Research [J1103510]
FX This work was supported by the grants from National key Basic Research
   Program of China (2012CB124702), 948 Program (2013-S15), Specialized
   Research Fund for the Doctoral Program of Higher Education
   (20110146130002), Program of National Natural Science Foundation of
   China (31172093, 30970356), and the National Science Foundation for
   Fostering Talents in Basic Research (J1103510).
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NR 33
TC 19
Z9 26
U1 0
U2 12
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0303-7207
J9 MOL CELL ENDOCRINOL
JI Mol. Cell. Endocrinol.
PD AUG 15
PY 2015
VL 411
IS C
BP 97
EP 104
DI 10.1016/j.mce.2015.04.015
PG 8
WC Cell Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Endocrinology & Metabolism
GA CL1XU
UT WOS:000356739000011
PM 25917454
OA Bronze
DA 2025-06-11
ER

PT J
AU Meeprom, A
   Sompong, W
   Suwannaphet, W
   Yibchok-anun, S
   Adisakwattana, S
AF Meeprom, Aramsri
   Sompong, Weerachat
   Suwannaphet, Wannaporn
   Yibchok-anun, Sirintorn
   Adisakwattana, Sirichai
TI Grape seed extract supplementation prevents high-fructose diet-induced
   insulin resistance in rats by improving insulin and adiponectin
   signalling pathways
SO BRITISH JOURNAL OF NUTRITION
LA English
DT Article
DE Grape seed extract; Fructose; Insulin signalling; Adiponectin
   signalling; Insulin resistance
ID INDUCED DIABETIC-RATS; SKELETAL-MUSCLE; OXIDATIVE STRESS; METABOLIC
   SYNDROME; RICH EXTRACT; IN-VIVO; PROTEIN; PROCYANIDINS; EXPRESSION;
   RECEPTORS
AB Recent evidence strongly supports the contention that grape seed extract (GSE) improves hyperglycaemia and hyperinsulinaemia in high-fructose-fed rats. To explore the underlying molecular mechanisms of action, we examined the effects of GSE on the expression of muscle proteins related to the insulin signalling pathway and of mRNA for genes involved in the adiponectin signalling pathway. Compared with rats fed on a normal diet, high-fructose-fed rats developed pathological changes, including insulin resistance, hyperinsulinaemia, hypertriacylglycerolaemia, a low level of plasma adiponectin and a high level of plasma fructosamine. These disorders were effectively attenuated in high-fructose-fed rats supplemented with GSE. A high-fructose diet causes insulin resistance by significantly reducing the protein expression of insulin receptor, insulin receptor substrate-1, Akt and GLUT4, and the mRNA expression of adiponectin, adiponectin receptor R1 (AdipoR1) and AMP-activated protein kinase (AMPK)-alpha in the skeletal muscle. Supplementation of GSE enhanced the expression of insulin signalling pathway-related proteins, including Akt and GLUT4. GSE also increased the mRNA expression of adiponectin, AdipoR1 and AMPK-alpha. In addition, GSE increased the mRNA levels of glycogen synthase and suppressed the mRNA expression of glycogen synthase kinase-3-alpha, causing an increase in glycogen accumulation in the skeletal muscle. These results suggest that GSE ameliorates the defective insulin and adiponectin signalling pathways in the skeletal muscle, resulting in improved insulin resistance in fructose-fed rats.
C1 [Adisakwattana, Sirichai] Chulalongkorn Univ, Fac Allied Hlth Sci, Program Nutr & Dietet, Bangkok, Thailand.
   [Meeprom, Aramsri; Sompong, Weerachat] Chulalongkorn Univ, Fac Allied Hlth Sci, Dept Clin Chem, Program Clin Biochem & Mol Med, Bangkok, Thailand.
   [Suwannaphet, Wannaporn; Yibchok-anun, Sirintorn] Chulalongkorn Univ, Fac Vet Sci, Dept Pharmacol, Bangkok, Thailand.
   [Adisakwattana, Sirichai] Chulalongkorn Univ, Med Food Res & Dev Ctr, Fac Allied Hlth Sci, Dept Transfus Med, Bangkok, Thailand.
C3 Chulalongkorn University; Chulalongkorn University; Chulalongkorn
   University; Chulalongkorn University
RP Adisakwattana, S (corresponding author), Chulalongkorn Univ, Fac Allied Hlth Sci, Program Nutr & Dietet, Bangkok, Thailand.
EM sirichai.a@chula.ac.th
OI Adisakwattana, Sirichai/0000-0002-7938-6561
FU Chulalongkorn University
FX The present study was financially supported by the 90th Anniversary of
   Chulalongkorn University Fund (Ratchadaphiseksomphot Endowment Fund).
   The authors would like to thank the Medical Food Research and
   Development Center, which has been financially and institutionally
   supported by the Chulalongkorn University. The authors' contributions
   were as follows: A. M., S. Y.-a., S. A. developed the concept and
   designed the study. In particular, A. M., W. So., W. Su. performed the
   study, collected and analysed the data; S. A. wrote the manuscript. The
   authors declare that they have no conflicts of interest.
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NR 44
TC 41
Z9 49
U1 0
U2 18
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1145
J9 BRIT J NUTR
JI Br. J. Nutr.
PD OCT
PY 2011
VL 106
IS 8
BP 1173
EP 1181
DI 10.1017/S0007114511001589
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 847LE
UT WOS:000296973600005
PM 21736810
OA Bronze
DA 2025-06-11
ER

PT J
AU Wen, X
   Peng, YD
   Zheng, BH
   Yang, SY
   Han, J
   Yu, F
   Zhou, TT
   Geng, L
   Yu, ZM
   Feng, L
AF Wen, Xin
   Peng, Yidi
   Zheng, Bohao
   Yang, Shaying
   Han, Jing
   Yu, Fan
   Zhou, Tingting
   Geng, Li
   Yu, Zhiming
   Feng, Lei
TI Silybin induces endothelium-dependent vasodilation via TRPV4 channels in
   mouse mesenteric arteries
SO HYPERTENSION RESEARCH
LA English
DT Article
DE Silybin; TRPV4; Endothelium-dependent vasodilation; Endothelial cell;
   Mesenteric artery
ID FATTY LIVER; DYSFUNCTION; SILIBININ; HYPERTENSION; FLAVONOIDS;
   SILYMARIN; STRESS
AB Silybin is a flavonolignan extracted from the seeds of Silybum marianum that has been used as a dietary supplement for treating hepatic diseases and components of metabolic syndrome such as diabetes, obesity and hypertension. Transient receptor potential vanilloid 4 (TRPV4) channels are Ca2+-permeable, nonselective cation channels that regulate vascular endothelial function and blood flow. However, the relationship between silybin and TRPV4 channels in small mesenteric arteries remains unknown. In our study, we carried out a molecular docking experiment by using Discovery Studio v3.5 to predict the binding of silybin to TRPV4. Activation of TRPV4 with silybin was detected via intracellular Ca2+ concentration ([Ca2+](i)) measurement and patch clamp experiments. The molecular docking results showed that silybin was likely to bind to the ankyrin repeat domain of TPRV4. [Ca2+](i) measurements in mesenteric arterial endothelial cells (MAECs) and TRPV4-overexpressing HEK293 (TRPV4-HEK293) cells demonstrated that silybin induced Ca2+ influx by activating TRPV4 channels. The patch clamp experiments indicated that in TRPV4-HEK293 cells, silybin induced TRPV4-mediated cation currents. In addition, in high-salt-induced hypertensive mice, oral administration of silybin decreased systolic blood pressure (SBP) and significantly improved the arterial dilatory response to acetylcholine. Our findings provide the first evidence that silybin could induce mesenteric endothelium-dependent vasodilation and reduce blood pressure in high-salt-induced hypertensive mice via TRPV4 channels, thereby revealing the potential effect of silybin on preventing endothelial dysfunction-related cardiovascular diseases.
C1 [Wen, Xin; Zheng, Bohao; Yang, Shaying; Han, Jing; Yu, Fan; Zhou, Tingting; Geng, Li; Feng, Lei] Jiangnan Univ, Wuxi Sch Med, Wuxi, Jiangsu, Peoples R China.
   [Peng, Yidi] Jiangnan Univ, Sch Pharmaceut Sci, Wuxi, Jiangsu, Peoples R China.
   [Yu, Zhiming] Nanjing Med Univ, Wuxi Peoples Hosp, Dept Cardiol, Wuxi, Jiangsu, Peoples R China.
   [Yu, Zhiming] Wuxi Inst Translat Med, Wuxi, Jiangsu, Peoples R China.
C3 Jiangnan University; Jiangnan University; Jiangnan University; Nanjing
   Medical University
RP Feng, L (corresponding author), Jiangnan Univ, Wuxi Sch Med, Wuxi, Jiangsu, Peoples R China.
EM feng2008lei@163.com
RI Zheng, Bohao/JXM-7394-2024; Zhiming, Yu/ABO-3403-2022
FU National Natural Science Foundation of China [81622007, 81960662,
   81800430]; Chang Jiang Scholars Program [Q2015106]; Fundamental Research
   Funds for the Central Universities [JUSRP51704A]; National First-Class
   Discipline Program of Food Science and Technology [JUFSTR20180101];
   Postdoctoral Research Funding Program of Jiangsu Province [2020Z427];
   Wuxi Health Commission [1286010241210430]
FX This work was fully supported by the National Natural Science Foundation
   of China [81622007, 81960662, 81800430], the Chang Jiang Scholars
   Program [Q2015106], Fundamental Research Funds for the Central
   Universities [JUSRP51704A], the National First-Class Discipline Program
   of Food Science and Technology [JUFSTR20180101], Postdoctoral Research
   Funding Program of Jiangsu Province [2020Z427], and Wuxi Health
   Commission [1286010241210430].
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NR 44
TC 6
Z9 6
U1 1
U2 16
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0916-9636
EI 1348-4214
J9 HYPERTENS RES
JI Hypertens. Res.
PD DEC
PY 2022
VL 45
IS 12
BP 1954
EP 1963
DI 10.1038/s41440-022-01000-4
EA SEP 2022
PG 10
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 6F4RP
UT WOS:000849148200002
PM 36056206
DA 2025-06-11
ER

PT J
AU Torres, LF
   Cogliati, B
   Otton, R
AF Torres, L. F.
   Cogliati, B.
   Otton, R.
TI Green Tea Prevents NAFLD by Modulation of miR-34a and miR-194 Expression
   in a High-Fat Diet Mouse Model
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Article
ID LIVER-DISEASE; MICRORNA EXPRESSION; LIPID-ACCUMULATION;
   INSULIN-RESISTANCE; POLYPHENOLS; INFLAMMATION; STEATOSIS; FIBROSIS;
   STRESS; HUMANS
AB Background/Aims. Nonalcoholic fatty liver disease (NAFLD) is considered the hepatic manifestation of metabolic syndrome. It is currently the most common chronic liver disease with complex pathogenesis and challenging treatment. Here, we investigated the hepatoprotective role of green tea (GT) and determined the involvement of miRNAs and its mechanism of action. Methods. Male C57Bl/6 mice were fed with a high-fat diet for 4 weeks. After this period, the animals received gavage with GT (500 mg/kg body weight) over 12 weeks (5 days/week). HepG2 cell lines were transfected with miR-34a or miR-194 mimetics and inhibitors to validate the in vivo results or were treated with TNF-alpha to evaluate miRNA regulation. Results. GT supplementation protects against NAFLD development by altering lipid metabolism, increasing gene expression involved in triglycerides and fatty acid catabolism, and decreasing uptake and lipid accumulation. This phenotype was accompanied by miR-34a downregulation and an increase in their mRNA targets Sirt1, Ppar alpha, and Insig2. GT upregulated hepatic miR-194 by inhibiting TNF-alpha action leading to a decrease in miR-194 target genes Hmgcs/Apoa5. Conclusion. Our study identified for the first time that the beneficial effects of GT in the liver can be due to the modulation of miRNAs, opening new perspectives for the treatment of NAFLD focusing on epigenetic regulation of miR-34a and miR-194 as green tea targets.
C1 [Torres, L. F.; Otton, R.] Cruzeiro do Sul Univ, Interdisciplinary Postgrad Programme Hlth Sci, Sao Paulo, SP, Brazil.
   [Cogliati, B.] Univ Sao Paulo, Sch Vet Med & Anim Sci, Dept Pathol, Sao Paulo, SP, Brazil.
C3 Universidade de Sao Paulo
RP Otton, R (corresponding author), Cruzeiro do Sul Univ, Interdisciplinary Postgrad Programme Hlth Sci, Sao Paulo, SP, Brazil.
EM rosemariotton@hotmail.com
RI Cogliati, Bruno/E-9956-2012; Otton, Rosemari/C-6531-2012
OI Cogliati, Bruno/0000-0002-1388-7240; Otton, Rosemari/0000-0001-5503-3967
FU Sao Paulo Research Foundation (FAPESP) [2015/21785-1, 2013/22293-0];
   Cruzeiro do Sul University
FX The authors thank Prof. Dr. Rodrigues AC for the contribution in the
   definition of the experimental design used in this study. This research
   was supported by the SAo Paulo Research Foundation (FAPESP,
   2015/21785-1, 2013/22293-0) and the Cruzeiro do Sul University.
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NR 45
TC 40
Z9 41
U1 0
U2 24
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PD DEC 4
PY 2019
VL 2019
AR 4168380
DI 10.1155/2019/4168380
PG 18
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA JX5MQ
UT WOS:000503779300002
PM 31885789
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Kurd, M
   Dehnou, VV
   Tavakoli, SA
   Gahreman, DE
AF Kurd, Mohammad
   Dehnou, Vahid Valipour
   Tavakoli, Seyed A.
   Gahreman, Daniel E.
TI Effects of endurance training on hippocampus DJ-1, cannabinoid receptor
   type 2 and blood glucose concentration in diabetic rats
SO JOURNAL OF DIABETES INVESTIGATION
LA English
DT Article
DE Metabolic syndrome; Neurodegenerative diseases; Physical activity
ID OXIDATIVE STRESS; NEUROPATHIC PAIN; GLYCEMIC CONTROL; ALPHA-SYNUCLEIN;
   MOUSE MODEL; EXERCISE; HYPERGLYCEMIA; EXPRESSION; THRESHOLD; METFORMIN
AB Aims/Introduction To investigate the effect of endurance training on hippocampus DJ-1 and cannabinoid receptor type 2 (CB2) protein and blood glucose concentration in diabetic rats. Materials and Methods A total of 32 rats were randomly divided into diabetic (D), diabetic and exercise (DE), exercise (E) and control (C) groups. The endurance training was carried out five times per week for 6 weeks. The hippocampus DJ-1 and CB2 were measured using an enzyme-linked immunosorbent assay method. Results The level of DJ-1 in the D group was significantly higher than the other groups (P <= 0.01). However, the level of DJ-1 was not significantly different between the C, E and DE groups. In addition, the level of CB2 was significantly lower in the D group compared with the other groups (P <= 0.01). Blood glucose was significantly higher in the D group compared with the DE group (P <= 0.05). Furthermore, a significant positive correlation between the level of DJ-1 and blood glucose was observed (r = 0.67, P <= 0.001). There was also a significant inverse correlation between the level of CB2 and blood glucose (r = -0.77, P <= 0.001). Conclusions The results of this study suggest that the level of DJ-1 and CB2 might change in response to diabetes, and regular aerobic exercise could mediate the effect of DJ-1 and CB2 on diabetes-induced neurodegenerative diseases.
C1 [Kurd, Mohammad; Dehnou, Vahid Valipour] Lorestan Univ, Fac Literature & Human Sci, Sports Sci Dept, Khorramabad, Iran.
   [Tavakoli, Seyed A.] Lorestan Univ Med Sci, Med Physiol Dept, Fac Med, Khorramabad, Iran.
   [Gahreman, Daniel E.] Charles Darwin Univ, Coll Hlth & Human Sci, Darwin, NT, Australia.
C3 Lorestan University; Lorestan University of Medical Sciences; Charles
   Darwin University
RP Dehnou, VV (corresponding author), Lorestan Univ, Fac Literature & Human Sci, Sports Sci Dept, Khorramabad, Iran.
EM valipour.v@lu.ac.ir
OI valipour dehnou, vahid/0000-0001-7049-8164; Gahreman,
   Daniel/0000-0002-2375-6746
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NR 56
TC 1
Z9 1
U1 0
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2040-1116
EI 2040-1124
J9 J DIABETES INVEST
JI J. Diabetes Investig.
PD JAN
PY 2019
VL 10
IS 1
BP 43
EP 50
DI 10.1111/jdi.12868
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA HG5BV
UT WOS:000454991700007
PM 29791076
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Fisher-Wellman, KH
   Ryan, TE
   Smith, CD
   Gilliam, LAA
   Lin, CT
   Reese, LR
   Torres, MJ
   Neufer, PD
AF Fisher-Wellman, Kelsey H.
   Ryan, Terence E.
   Smith, Cody D.
   Gilliam, Laura A. A.
   Lin, Chien-Te
   Reese, Lauren R.
   Torres, Maria J.
   Neufer, P. Darrell
TI A Direct Comparison of Metabolic Responses to High-Fat Diet in C57BL/6J
   and C57BL/6NJ Mice
SO DIABETES
LA English
DT Article
ID NICOTINAMIDE NUCLEOTIDE TRANSHYDROGENASE; PYRUVATE-DEHYDROGENASE
   COMPLEX; INSULIN-RESISTANCE; GLUCOSE-HOMEOSTASIS; SKELETAL-MUSCLE; MOUSE
   STRAINS; GLUTATHIONE; SUBSTRAINS; SECRETION; HYPERGLYCEMIA
AB Although nicotinamide nucleotide transhydrogenase (NNT)-deficient C57BU6J (6J) mice are known to be highly susceptible to diet-induced metabolic disease, this notion stems primarily from comparisons of 6J mice to other inbred strains. To date, very few studies have directly compared metabolic disease susceptibility between NNT-deficient 6J mice and NNT-competent C57BL/6 substrains. In this study, comprehensive profiling of the metabolic response to a high-fat/high-sucrose diet (HFD) were compared across time in 6J and C57BU6NJ (6N) mice. Given that increased peroxide exposure drives insulin resistance, coupled with the fact that NNT regulates peroxide detoxification, it was hypothesized that 6J mice would experience greater derangements in redox homeostasis/metabolic disease upon HFD exposure. Contrary to this, both lines were found to be highly susceptible to diet-induced metabolic disease, as evidenced by impairments in glucose tolerance as early as 24 h into the HFD. Moreover, various markers of the metabolic syndrome, as well as peroxide stress, were actually blunted, rather than exacerbated, in the 6J mice, likely reflecting compensatory increases in alterative redoxbuffering pathways. Together, these data provide evidence that the susceptibility to HFD-induced metabolic disease is similar in the 6J and 6N substrains. Given the numerous genetic variances in the 6J stain, including loss of NNT function, these findings suggest that the 6N sub strain is the more logical and representative genetic background model for metabolic studies.
C1 [Fisher-Wellman, Kelsey H.; Ryan, Terence E.; Smith, Cody D.; Gilliam, Laura A. A.; Lin, Chien-Te; Reese, Lauren R.; Torres, Maria J.; Neufer, P. Darrell] East Carolina Univ, East Carolina Diabet & Obes Inst, Greenville, NC 27858 USA.
   [Fisher-Wellman, Kelsey H.] Duke Univ, Duke Mol Physiol Inst, Durham, NC USA.
   [Ryan, Terence E.; Smith, Cody D.; Gilliam, Laura A. A.; Lin, Chien-Te; Reese, Lauren R.; Neufer, P. Darrell] East Carolina Univ, Dept Physiol, Greenville, NC 27858 USA.
   [Torres, Maria J.; Neufer, P. Darrell] East Carolina Univ, Dept Kinesiol, Greenville, NC 27858 USA.
C3 University of North Carolina; East Carolina University; Duke University;
   University of North Carolina; East Carolina University; University of
   North Carolina; East Carolina University
RP Neufer, PD (corresponding author), East Carolina Univ, East Carolina Diabet & Obes Inst, Greenville, NC 27858 USA.; Neufer, PD (corresponding author), East Carolina Univ, Dept Physiol, Greenville, NC 27858 USA.; Neufer, PD (corresponding author), East Carolina Univ, Dept Kinesiol, Greenville, NC 27858 USA.
EM neuferp@ecu.edu
RI Fisher-Wellman, Kelsey/O-8209-2019; Ryan, Terence/W-5576-2019
OI Lin, Chien-Te/0000-0001-6449-006X; Torres, Maria J./0000-0002-7551-8053
FU National Institutes of Health [1F32-AR-061946, 1-R01-096907]
FX This work was supported by National Institutes of Health grants
   1F32-AR-061946 (to L.A.A.G.) and 1-R01-096907 (to P.D.N.).
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NR 37
TC 85
Z9 102
U1 1
U2 12
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0012-1797
EI 1939-327X
J9 DIABETES
JI Diabetes
PD NOV
PY 2016
VL 65
IS 11
BP 3249
EP 3261
DI 10.2337/db16-0291
PG 13
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA EA3VX
UT WOS:000386538500006
PM 27495226
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Gonçalves, JP
   Severo, M
   Rangel, I
   De Sousa, C
   Maciel, MJ
   Lopes, C
AF Goncalves, Jean-Pierre
   Severo, Milton
   Rangel, Ines
   De Sousa, Carla
   Maciel, Maria Julia
   Lopes, Carla
TI Short-Time Variation in Serum Uric Acid Concentrations in
   Post-Myocardial Infarction Patients
SO CLINICAL LABORATORY
LA English
DT Article
DE uric acid; acute myocardial infarction; hyperuricemia
ID TYPE-2 DIABETES-MELLITUS; CORONARY-HEART-DISEASE; METABOLIC SYNDROME;
   XANTHINE-OXIDASE; RISK; ATHEROSCLEROPATHY; STRESS
AB Background: Studies on SUA temporal profile in relation to acute myocardial infarction (AMI) are controversial. The aim of this study was to evaluate the SUA level variations following myocardial infarction.
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   Results: The mean plasma concentration of SUA was lower at baseline (58.5 +/- 18.9 mg/L). The ICC across the three time points was 0.75 (95% CI 0.70 - 0.80). SUA levels increased 1.33 mg/L per day after AIVII (2.3 mg/L/day in women and 1.0 mg/L/day in men). Normouricemic patients had a 1.6 fold increase risk to change to hyperuricemic status per day after AMI (OR = 1.60, 95% CI: 1.27 - 2.00).
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C1 [Goncalves, Jean-Pierre; Severo, Milton; Lopes, Carla] Univ Porto, Inst Publ Hlth, P-4200319 Oporto, Portugal.
   [Goncalves, Jean-Pierre; Severo, Milton; Lopes, Carla] Dept Clin Epidemiol Predict Med & Publ Hlth, Oporto, Portugal.
   [Maciel, Maria Julia; Lopes, Carla] Univ Porto, Sch Med, Cardiovasc Res & Dev Unit, P-4200319 Oporto, Portugal.
   [Rangel, Ines; De Sousa, Carla; Maciel, Maria Julia] Hosp Sao Joao, Dept Cardiol, Oporto, Portugal.
C3 Universidade do Porto; Universidade do Porto; Sao Joao Hospital
RP Gonçalves, JP (corresponding author), Univ Porto, Sch Med, Dept Hyg & Epidemiol, Alameda Prof Hernani Monteiro, P-4200319 Oporto, Portugal.
EM pierre_3.14r@hotmail.com
RI Goncalves, Jean/KIB-8288-2024; Sund, Reijo/N-5471-2016; Lopes,
   Carla/U-9327-2017; Sousa, Carla/Y-5183-2019; Severo, Milton/I-3497-2012
OI Goncalves, Jean-Pierre/0000-0001-7381-0766; Maciel, Maria
   Julia/0000-0001-7623-467X; Lopes, Carla/0000-0003-1524-852X; Sousa,
   Carla/0000-0003-2313-0775; Severo, Milton/0000-0002-5787-4871
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NR 30
TC 2
Z9 2
U1 0
U2 7
PU CLIN LAB PUBL
PI HEIDELBERG
PA IM BREITSPIEL 15, HEIDELBERG, D-69126, GERMANY
SN 1433-6510
J9 CLIN LAB
JI Clin. Lab.
PY 2013
VL 59
IS 3-4
BP 263
EP 270
DI 10.7754/Clin.Lab.2012.120628
PG 8
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA 278TP
UT WOS:000328913000004
PM 23724613
DA 2025-06-11
ER

PT J
AU Cao, L
   Mao, CP
   Li, SG
   Zhang, YJ
   Lv, JX
   Jiang, S
   Xu, ZC
AF Cao, Li
   Mao, Caiping
   Li, Shigang
   Zhang, Yujuan
   Lv, Juanxiu
   Jiang, Shan
   Xu, Zhice
TI Hepatic Insulin Signaling Changes: Possible Mechanism in Prenatal
   Hypoxia-Increased Susceptibility of Fatty Liver in Adulthood
SO ENDOCRINOLOGY
LA English
DT Article
ID INTRAUTERINE GROWTH RESTRICTION; INDUCED METABOLIC SYNDROME;
   NONALCOHOLIC STEATOHEPATITIS; MITOCHONDRIAL DYSFUNCTION;
   DIABETES-MELLITUS; SKELETAL-MUSCLE; GENE-EXPRESSION; RAT MODEL;
   RESISTANCE; GLUCOSE
AB Nonalcoholic fatty liver disease (NAFLD) is strongly linked to insulin resistance. Prenatal hypoxia (PH) is a risk factor in programming of insulin resistance, glucose intolerance, and metabolic dysfunctions in later life, although the mechanisms are unclear. In this study, the role of metabolic and histological changes as well as the hepatic insulin signaling mechanisms were determined in increasing susceptibility of NAFLD in the fetus and offspring exposed to PH. Pregnant rats exposed to hypoxia (O-2 10%) during pregnancy demonstrated decreased fetal body and liver weight as well as liver to body weight ratio, whereas these changes were not observed in the offspring. However, male liver to body weight ratio increased after PH stress. Microscopic analysis demonstrated that exposure to PH resulted in distorted architecture of the hepatic parenchyma cells with reduced cellularity in the fetus and offspring. Blood glucose and insulin levels were lower with enhanced insulin sensitivity and increased expression of hepatic insulin-signaling elements in the fetus. Furthermore, insulin resistance, impaired glucose homeostasis, and altered expression of insulin-signaling elements occurred in the offspring. Postnatal hypoxia increased hepatic lipid droplets and triglyceride in liver, whereas expressions of insulin-signaling elements were less in the offspring exposed to PH except glucose transporters 2. The results indicated that PH contributed to hepatocyte heteroplasia and metabolic changes that enhanced vulnerability for NAFLD in the offspring, probably via affecting insulin signaling pathway, including glucose transporters 2. (Endocrinology 153: 4955-4965, 2012)
C1 [Cao, Li; Mao, Caiping; Li, Shigang; Zhang, Yujuan; Lv, Juanxiu; Jiang, Shan; Xu, Zhice] Soochow Univ, Affiliated Hosp 1, Inst Fetal Origin Dis, Suzhou 215006, Peoples R China.
   [Cao, Li; Mao, Caiping; Li, Shigang; Zhang, Yujuan; Lv, Juanxiu; Jiang, Shan; Xu, Zhice] Soochow Univ, Affiliated Hosp 1, Reprod Med Ctr, Suzhou 215006, Peoples R China.
   [Cao, Li] Soochow Univ, Coll Pharm, Suzhou 215006, Peoples R China.
C3 Soochow University - China; Soochow University - China; Soochow
   University - China
RP Mao, CP (corresponding author), Soochow Univ, Affiliated Hosp 1, Inst Fetal Origin Dis, Suzhou 215006, Peoples R China.
EM maocp1018@163.com; xuzhice@suda.edu.cn
FU National Natural Science Foundation of China [30902018, 81030006,
   81100448, 81100431]; Jiangsu Key Discipline/Laboratory of Medicine and
   "ChuangXinTuanDui" funds;  [2012CB947600]
FX This work was partially supported by Grant 2012CB947600; the National
   Natural Science Foundation of China [Grant 30902018 (to L. C.), Grant
   81030006 (to Z.X.), Grant 81100448 (to Y.Z.), and Grant 81100431 (to
   J.L.)]; and Jiangsu Key Discipline/Laboratory of Medicine and
   "ChuangXinTuanDui" funds (to Z.X.)].
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NR 53
TC 39
Z9 43
U1 1
U2 12
PU ENDOCRINE SOC
PI CHEVY CHASE
PA 8401 CONNECTICUT AVE, SUITE 900, CHEVY CHASE, MD 20815-5817 USA
SN 0013-7227
J9 ENDOCRINOLOGY
JI Endocrinology
PD OCT
PY 2012
VL 153
IS 10
BP 4955
EP 4965
DI 10.1210/en.2012-1349
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 012BK
UT WOS:000309210200037
PM 22903613
OA Bronze
DA 2025-06-11
ER

PT J
AU Lee, SJ
   Cho, KH
   Kim, JC
   Choo, HJ
   Hwang, JY
   Cho, HC
   Hah, YS
AF Lee, Seung-Jun
   Cho, Kyoung Hwan
   Kim, Jong Cheol
   Choo, Ho Jin
   Hwang, Jeong-Yun
   Cho, Hyun Chin
   Hah, Young-Sool
TI Comparative analysis of anti-obesity effects of green, fermented, and
   γ-aminobutyric acid teas in a high-fat diet-induced mouse model
SO APPLIED BIOLOGICAL CHEMISTRY
LA English
DT Article
DE Anti-obesity effects; Green tea; Fermented tea; GABA tea; High-fat
   diet-induced obesity
ID HEALTH; OBESITY; POLYPHENOLS; CONSUMPTION; BIOMARKERS
AB Obesity, a prevalent disease associated with numerous chronic conditions, including hyperlipidemia, hyperglycemia, diabetes, and metabolic syndrome, remains a major global health challenge. This study investigated the potential of green tea (GT), fermented tea (FT), and gamma-aminobutyric acid (GABA) tea (GBT), which are rich in phytonutrients and polyphenols, for the management of obesity. Using a high-fat diet-induced obese mouse model (C57BL/6N), we explored the effect of these teas on various obesity-related parameters. The mice were categorized into five groups: normal diet with water, high-fat diet with water, and high-fat diet supplemented with GT, FT, or GBT. Over 13 weeks, we monitored body weight, perirenal and liver fat, adipocyte lipid accumulation, and key metabolic indicators, such as serum cholesterol, leptin, insulin, and fasting blood glucose. These teas contain beneficial phytochemicals such as GABA, theanine, and caffeine, and have demonstrated an enhanced antioxidant capacity, which increases the scavenging of free radicals and may reduce oxidative stress. The animal study indicated a decrease in feeding efficiency and significant reductions in body weight liver fat, epididymal fat, and perirenal fat, as well as in adipocyte lipid accumulation. Additionally, notable improvements were observed in metabolic health indicators, including reductions in serum cholesterol, leptin, insulin, and fasting blood glucose levels. Our findings revealed that GT, FT, or GBT significantly counteracted the negative effects of a high-fat diet, suggesting their potential in combating obesity and related metabolic disorders.
C1 [Lee, Seung-Jun; Hwang, Jeong-Yun] Gyeongsang Natl Univ, Dept Convergence Med Sci, Jinju 52727, South Korea.
   [Cho, Kyoung Hwan; Kim, Jong Cheol] Inst Hadong Green Tea, Hadong 52304, South Korea.
   [Choo, Ho Jin] Jeongok Co Ltd, Jinkyo 52343, South Korea.
   [Cho, Hyun Chin] Gyeongsang Natl Univ, Sch Med, Dept Internal Med, Jinju 52727, South Korea.
   [Cho, Hyun Chin] Gyeongsang Natl Univ Hosp, Jinju 52727, South Korea.
   [Hah, Young-Sool] Gyeongsang Natl Univ, Gyoengsang Natl Univ Hosp, Biomed Res Inst, Inst Med Sci,Sch Med, Jinju 52727, South Korea.
C3 Gyeongsang National University; Gyeongsang National University;
   Gyeongsang National University; Gyeongsang National University Hospital;
   Gyeongsang National University
RP Cho, HC (corresponding author), Gyeongsang Natl Univ, Sch Med, Dept Internal Med, Jinju 52727, South Korea.; Cho, HC (corresponding author), Gyeongsang Natl Univ Hosp, Jinju 52727, South Korea.; Hah, YS (corresponding author), Gyeongsang Natl Univ, Gyoengsang Natl Univ Hosp, Biomed Res Inst, Inst Med Sci,Sch Med, Jinju 52727, South Korea.
EM hccholuck@gmail.com; yshah@gnu.ac.kr
FU Basic Science Research Program through the National Research Foundation
   of Korea [NRF-2021R1F1A1057920]
FX This work was supported by the Basic Science Research Program through
   the National Research Foundation of Korea (NRF-2021R1F1A1057920).
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TC 4
Z9 4
U1 4
U2 9
PU SPRINGER SINGAPORE PTE LTD
PI SINGAPORE
PA 152 Beach Road, #21-01 Gateway East, SINGAPORE, SINGAPORE
SN 2468-0834
EI 2468-0842
J9 APPL BIOL CHEM
JI Appl. Biol. Chem.
PD MAR 26
PY 2024
VL 67
IS 1
AR 36
DI 10.1186/s13765-024-00888-5
PG 12
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA MB8Z8
UT WOS:001191272000001
OA gold
DA 2025-06-11
ER

PT J
AU Sokan-Adeaga, AA
   Sokan-Adeaga, MA
   Sokan-Adeaga, ED
   Oparaji, AN
   Edris, H
   Tella, EO
   Balogun, FA
   Aledeh, M
   Amubieya, OE
AF Sokan-Adeaga, Adewale Allen
   Sokan-Adeaga, Micheal Ayodeji
   Sokan-Adeaga, Eniola Deborah
   Oparaji, Anastasia Nkem
   Edris, Hoseinzadeh
   Tella, Esther Oluwabukunola
   Balogun, Francis Adeniyi
   Aledeh, Muhammad
   Amubieya, Oluwatosin Emmanuel
TI Environmental toxicants and health adversities: A review on
   interventions of phytochemicals
SO JOURNAL OF PUBLIC HEALTH RESEARCH
LA English
DT Review
DE Environmental toxicants; phytochemicals; prophylactics; therapeutics;
   plants; intervention; medicinal properties
ID POLYCYCLIC AROMATIC-HYDROCARBONS; TEA TREE OIL; POLYUNSATURATED
   FATTY-ACIDS; OXIDATIVE STRESS; PROSTATE-CANCER; DOUBLE-BLIND;
   ANTIOXIDANT PROPERTIES; PYRETHROID PESTICIDE; METABOLIC SYNDROME;
   PHENOLIC-COMPOUNDS
AB Toxicity arising from environmental contaminants has attracted global interest in the last few decades, due to the high morbidity and mortality associated with them. Efforts have been made to combat the consequential outcomes of environmental toxicity in humans through traditional remediation techniques and therapeutic measures which have been hampered by one or more limitations. Consequently, this scenario has triggered interest in the medicinal properties of phytochemicals. Thus, this review gives a succinct and in-depth elucidation of the various environmental contaminants and their toxicity effects on humans. It delves into the various classes of phytochemicals and their intervention roles. The study adopted a desk review of existing literatures from scientific reports and peer reviewed articles through triangulation of data sources. "Phytochemicals" are group of secondary metabolites obtained from plants with medicinal properties. These groups of compounds are included but not limited to flavonoids, tannins, saponins, alkaloids, cardenoloids, terpenoids, and phytosteroids. This review corroborates the prophylactic and therapeutics efficacy of these phytochemicals as anti-metastatic, anti-inflammatory, anti-aging, anti-oxidant, anti-microbial and live saving substances with empirical findings from several laboratory, clinical trials and epidemiologic studies. It conclude that given the wide range of medicinal properties of phytochemicals, there is an urgent need for its full optimization in the pharmaceutical industry and future studies should focus on identifying the bioactive molecules in these compounds and its effectiveness against mixer toxicity.
C1 [Sokan-Adeaga, Adewale Allen; Tella, Esther Oluwabukunola] Lead City Univ, Coll Med, Fac Publ Hlth, Dept Environm Hlth Sci, Ibadan, Nigeria.
   [Sokan-Adeaga, Micheal Ayodeji] Univ Lagos, Coll Med, Fac Clin Sci, Dept Community Hlth & Primary Hlth Care, Lagos, Nigeria.
   [Sokan-Adeaga, Eniola Deborah] Ladoke Akintola Univ Technol LAUTECH, Coll Med, Fac Basic Med Sci, Dept Physiol, Ogbomosho, Oyo, Nigeria.
   [Oparaji, Anastasia Nkem] Chrisland Univ, Dept Nursing Sci, Abeokuta, Ogun, Nigeria.
   [Edris, Hoseinzadeh] Saveh Univ Med Sci, Incubat & Innovat Ctr, Saveh, Iran.
   [Balogun, Francis Adeniyi] Lead City Univ, Coll Med, Fac Publ Hlth, Dept Community Hlth, Ibadan, Nigeria.
   [Aledeh, Muhammad] Univ Derby, Coll Hlth Psychol & Social Care, Derby, England.
   [Aledeh, Muhammad] Wiener Gesundheitsverbund, Klin Donaustadt, Psychiat Dept, Vienna, Austria.
   [Amubieya, Oluwatosin Emmanuel] Univ Ibadan, Fac Publ Hlth, Dept Environm Hlth Sci, Ibadan, Nigeria.
   [Sokan-Adeaga, Adewale Allen] Lead City Univ Ibadan, Coll Med, Fac Publ Hlth, Dept Environm Hlth Sci, Toll Gate Area,POB 30678, Ibadan 200255, Oyo, Nigeria.
C3 University of Lagos; University of Derby; University of Ibadan
RP Sokan-Adeaga, AA (corresponding author), Lead City Univ Ibadan, Coll Med, Fac Publ Hlth, Dept Environm Hlth Sci, Toll Gate Area,POB 30678, Ibadan 200255, Oyo, Nigeria.
EM sokanadeaga.adewaleallen@yahoo.com
RI Aledeh, Muhammad/GRY-6487-2022; SOKAN-ADEAGA, ADEWALE
   ALLEN/AAO-6199-2020; SOKAN-ADEAGA, MICHEAL AYODEJI/ABC-6735-2022;
   SOKAN-ADEAGA, ENIOLA DEBORAH/AEO-2438-2022
OI Aledeh, Muhammad/0000-0002-6831-9005; SOKAN-ADEAGA, ADEWALE
   ALLEN/0000-0002-0885-1526; SOKAN-ADEAGA, MICHEAL
   AYODEJI/0000-0001-8550-1960; SOKAN-ADEAGA, ENIOLA
   DEBORAH/0000-0002-1837-5287
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NR 177
TC 13
Z9 14
U1 2
U2 9
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 2279-9028
EI 2279-9036
J9 J PUBLIC HEALTH RES
JI J. Public Health Res.
PD JUN
PY 2023
VL 12
IS 2
AR 22799036231181226
DI 10.1177/22799036231181226
PG 20
WC Public, Environmental & Occupational Health
WE Emerging Sources Citation Index (ESCI)
SC Public, Environmental & Occupational Health
GA K9KM7
UT WOS:001019552200001
PM 37440795
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Liang, HB
   Yuan, XM
   Sun, CH
   Sun, Y
   Yang, M
   Feng, S
   Yao, JC
   Liu, Z
   Zhang, GM
   Li, F
AF Liang, Hongbao
   Yuan, Xiaomei
   Sun, Chenghong
   Sun, Ying
   Yang, Min
   Feng, Shuai
   Yao, Jingchun
   Liu, Zhong
   Zhang, Guimin
   Li, Feng
TI Preparation of a new component group of Ginkgo biloba leaves and
   investigation of the antihypertensive effects in spontaneously
   hypertensive rats
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Article
DE Ginkgo biloba; Antihypertensive effect; Flavonoid aglycone; Terpenoid
   lactone; Cocrystal; Cardiac hypertrophy
ID FLAVONOID QUERCETIN; METABOLIC SYNDROME; CHEMICAL-ANALYSIS;
   QUALITY-CONTROL; BLOOD-PRESSURE; EXTRACT; BIOAVAILABILITY; INJURY
AB Ginkgo (Ginkgo biloba L.) is a traditional economic tree species in China. Ginkgo biloba extract (GBE) is widely used in combination to treat hypertension and complications in clinical practice. However, the antihypertensive effect of GBE alone is weak and it is also difficult to study the mechanism because of its complex composition. This study was to prepare a new component group of Ginkgo biloba leaves (GBLCG) with clear chemical structures, and to investigate its effect on reducing blood pressure and improving myocardial hypertrophy in spontaneously hypertensive rats with GBE and amlodipine as positive controls. The results showed that total flavonoid aglycones (TFAs) of GBLCG was mainly composed of quercetin (QCT), kaempferol (KMF) and iso-rhamnetin (ISR); Total terpenoid lactones (TTLs) of GBLCG might be a novel cocrystal composed of Ginkgolide A (GA), Ginkgolide B (GB) Ginkgolide C (GC), Ginkgolide J (GJ) and bilobalide (BB). The hypotensive activity of GBLCG (4.4 mg/kg) group was better than that of GBE group (p < 0.05), and the effect of improving myocardial hypertrophy was better than that of amlodipine besylate group (p < 0.01). GBLCG might reduce blood pressure and improve myocardial hypertrophy by promoting the synthesis and release of NO in endothelial cells, reducing oxidative stress, inhibiting platelet aggregation and promoting lesion circulation. Eventually, we hope to introduce GBLCG as a new drug for hypertension.
C1 [Liang, Hongbao; Sun, Ying; Yang, Min; Feng, Shuai; Li, Feng] Shandong Univ Tradit Chinese Med, 4655 Daxue Rd, Jinan 250355, Peoples R China.
   [Liang, Hongbao; Sun, Chenghong; Yao, Jingchun; Liu, Zhong; Zhang, Guimin] Shandong New Time Pharmaceut Co Ltd, Linyi, Shandong, Peoples R China.
   [Liang, Hongbao; Yuan, Xiaomei; Sun, Chenghong; Sun, Ying; Yao, Jingchun; Liu, Zhong; Zhang, Guimin] Lunan Pharmaceut Grp Co Ltd, State Key Lab Gener Manufacture Technol Chinese T, 209 Hongqi Rd, Linyi 276006, Shandong, Peoples R China.
C3 Shandong University of Traditional Chinese Medicine
RP Li, F (corresponding author), Shandong Univ Tradit Chinese Med, 4655 Daxue Rd, Jinan 250355, Peoples R China.; Zhang, GM (corresponding author), Lunan Pharmaceut Grp Co Ltd, State Key Lab Gener Manufacture Technol Chinese T, 209 Hongqi Rd, Linyi 276006, Shandong, Peoples R China.
EM lunanzhangguimin@yeah.net; 13969141796@163.com
RI Liang, Hongbao/AGA-8305-2022
FU National Science and Technology Major Project for Key New Drug
   Development of China [2017ZX09301058]; National Natural Science
   Foundation of China [82004233]; Project of Medical and Health Technology
   Develop-ment Program in Shandong Province [202013030996]
FX This study was supported by the National Science and Technology Major
   Project for Key New Drug Development of China [No. 2017ZX09301058] ;
   National Natural Science Foundation of China [No. 82004233] ; and
   Project of Medical and Health Technology Develop-ment Program in
   Shandong Province [No. 202013030996] .
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U2 41
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD MAY
PY 2022
VL 149
AR 112805
DI 10.1016/j.biopha.2022.112805
EA MAR 2022
PG 11
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA 1M9NZ
UT WOS:000800293000006
PM 35276465
OA gold
DA 2025-06-11
ER

PT J
AU Cleven, KL
   Rosenzvit, C
   Nolan, A
   Zeig-Owens, R
   Kwon, S
   Weiden, MD
   Skerker, M
   Halpren, A
   Prezant, DJ
AF Cleven, Krystal L.
   Rosenzvit, Carla
   Nolan, Anna
   Zeig-Owens, Rachel
   Kwon, Sophia
   Weiden, Michael D.
   Skerker, Molly
   Halpren, Allison
   Prezant, David J.
TI Twenty-Year Reflection on the Impact of World Trade Center Exposure on
   Pulmonary Outcomes in Fire Department of the City of New York (FDNY)
   Rescue and Recovery Workers
SO LUNG
LA English
DT Review
DE World trade center; 9; 11; Obstructive airways disease; Lung injury;
   Occupational exposure
ID POSTTRAUMATIC-STRESS-DISORDER; METABOLIC SYNDROME BIOMARKERS;
   OBSTRUCTIVE SLEEP-APNEA; FOOD-INTAKE RESTRICTION; CENTER COUGH-SYNDROME;
   CENTER-LUNG INJURY; CENTER DUST; CENTER DISASTER; EDUCATION FIREHOUSE;
   TERRORIST ATTACKS
AB After the terrorist attacks on September 11, 2001 (9/11), many rescue/recovery workers developed respiratory symptoms and pulmonary diseases due to their extensive World Trade Center (WTC) dust cloud exposure. Nearly all Fire Department of the City of New York (FDNY) workers were present within 48 h of 9/11 and for the next several months. Since the FDNY had a well-established occupational health service for its firefighters and Emergency Medical Services workers prior to 9/11, the FDNY was able to immediately start a rigorous monitoring and treatment program for its WTC-exposed workers. As a result, respiratory symptoms and diseases were identified soon after 9/11. This focused review summarizes the WTC-related respiratory diseases that developed in the FDNY cohort after 9/11, including WTC cough syndrome, obstructive airways disease, accelerated lung function decline, airway hyperreactivity, sarcoidosis, and obstructive sleep apnea. Additionally, an extensive array of biomarkers has been identified as associated with WTC-related respiratory disease. Future research efforts will not only focus on further phenotyping/treating WTC-related respiratory disease but also on additional diseases associated with WTC exposure, especially those that take decades to develop, such as cardiovascular disease, cancer, and interstitial lung disease.
C1 [Cleven, Krystal L.; Rosenzvit, Carla; Zeig-Owens, Rachel; Skerker, Molly; Prezant, David J.] Montefiore Med Ctr, Dept Med, Pulm Med Div, Bronx, NY 10467 USA.
   [Cleven, Krystal L.; Rosenzvit, Carla; Zeig-Owens, Rachel; Skerker, Molly; Prezant, David J.] Albert Einstein Coll Med, Bronx, NY 10467 USA.
   [Nolan, Anna; Zeig-Owens, Rachel; Weiden, Michael D.; Skerker, Molly; Halpren, Allison; Prezant, David J.] Bur Hlth Serv, Brooklyn, NY USA.
   [Nolan, Anna; Zeig-Owens, Rachel; Weiden, Michael D.; Skerker, Molly; Halpren, Allison; Prezant, David J.] Fire Dept City New York, FDNY World Trade Ctr Hlth Program, Brooklyn, NY USA.
   [Nolan, Anna; Kwon, Sophia; Weiden, Michael D.] NYU, Dept Med, Grossman Sch Med, Pulm Crit Care & Sleep Med Div, 550 1St Ave, New York, NY 10016 USA.
   [Nolan, Anna; Weiden, Michael D.] NYU, Dept Environm Med, Grossman Sch Med, 550 1St Ave, New York, NY 10016 USA.
   [Zeig-Owens, Rachel; Prezant, David J.] Albert Einstein Coll Med, Dept Epidemiol & Populat Hlth, Div Epidemiol, Bronx, NY 10467 USA.
C3 Montefiore Medical Center; Albert Einstein College of Medicine; Yeshiva
   University; Montefiore Medical Center; Albert Einstein College of
   Medicine; New York University; New York University; Yeshiva University;
   Montefiore Medical Center; Albert Einstein College of Medicine
RP Cleven, KL (corresponding author), Montefiore Med Ctr, Dept Med, Pulm Med Div, Bronx, NY 10467 USA.; Cleven, KL (corresponding author), Albert Einstein Coll Med, Bronx, NY 10467 USA.
EM kcleven@montefiore.org
RI Zeig-Owens, Rachel/HIA-8364-2022; Nolan, Anna/C-2796-2012
OI Cleven, Krystal/0000-0002-6921-9743; Nolan, Anna/0000-0002-0631-1171
FU National Institute for Occupational Safety and Health [200-2017-93426,
   2002017-93326, U01-OH11300, U01-OH011855, U01-OH012069]; National Heart,
   Lung, and Blood Institute [R01HL119326]
FX The funded was provided by National Institute for Occupational Safety
   and Health (Grant Nos. 200-2017-93426 (World Trade Center Health Program
   Clinical Center of Excellence), 2002017-93326 (World Trade Center Health
   Program Data Center), U01-OH11300, U01-OH011855 and U01-OH012069) and
   National Heart, Lung, and Blood Institute (Grant No. R01HL119326).
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NR 93
TC 18
Z9 18
U1 0
U2 7
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0341-2040
EI 1432-1750
J9 LUNG
JI Lung
PD DEC
PY 2021
VL 199
IS 6
BP 569
EP 578
DI 10.1007/s00408-021-00493-z
EA NOV 2021
PG 10
WC Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Respiratory System
GA XD7HK
UT WOS:000717396100001
PM 34766209
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Hou, JS
   Wang, CH
   Lai, YH
   Kuo, CH
   Lin, YL
   Hsu, BG
   Tsai, JP
AF Hou, Jia-Sian
   Wang, Chih-Hsien
   Lai, Yu-Hsien
   Kuo, Chiu-Huang
   Lin, Yu-Li
   Hsu, Bang-Gee
   Tsai, Jen-Pi
TI Serum Malondialdehyde-Modified Low-Density Lipoprotein Is a Risk Factor
   for Central Arterial Stiffness in Maintenance Hemodialysis Patients
SO NUTRIENTS
LA English
DT Article
DE malondialdehyde-modified low-density lipoprotein; aortic stiffness;
   hemodialysis; carotid-femoral pulse wave velocity
ID PULSE-WAVE VELOCITY; LIPID-LOWERING THERAPY; ALL-CAUSE MORTALITY;
   CARDIOVASCULAR EVENTS; METABOLIC SYNDROME; AORTIC STIFFNESS;
   BLOOD-PRESSURE; MODIFIED LDL; CORONARY; ASSOCIATION
AB Circulating malondialdehyde-modified low-density lipoprotein (MDA-LDL) acts as a marker of oxidative stress and is associated with atherosclerotic cardiovascular disease. The relationship between serum MDA-LDL levels and aortic stiffness (AS) in patients with hemodialysis (HD) was evaluated. There were 155 HD patients enrolled in this study. Carotid-femoral pulse wave velocity (cfPWV) was measured by a validated tonometry system. Patients with cfPWV >10 m/s were used to define the AS group, while those with values of <= 10 m/s were regarded as the control group. Serum MDA-LDL levels were measured using a commercial enzyme-linked immunosorbent assay. Sixty-eight patients (43.9%) who were defined as AS sufferers, and were older, had a higher percentage of diabetes and hypertension and higher systolic blood pressure and serum MDA-LDL level compared to subjects in the control group. After adjusting for factors significantly associated with AS by multivariable logistic regression analysis, it was revealed that serum MDA-LDL levels, diabetes, and hypertension were independent predictors of AS in HD patients. Multivariable forward stepwise linear regression analysis also showed that a logarithmically transformed MDA-LDL level was significantly correlated with cfPWV values in HD patients. In HD patients, a high serum MDA-LDL level was positively associated with cfPWV values and was a significant predictor of the development of high AS.
C1 [Hou, Jia-Sian; Wang, Chih-Hsien; Lai, Yu-Hsien; Kuo, Chiu-Huang; Lin, Yu-Li; Hsu, Bang-Gee] Buddhist Tzu Chi Med Fdn, Hualien Tzu Chi Hosp, Div Nephrol, Hualien 97010, Taiwan.
   [Wang, Chih-Hsien; Lin, Yu-Li; Hsu, Bang-Gee; Tsai, Jen-Pi] Tzu Chi Univ, Sch Med, Hualien 97004, Taiwan.
   [Kuo, Chiu-Huang] Tzu Chi Univ, Sch Postbaccalaureate Chinese Med, Hualien 97010, Taiwan.
   [Tsai, Jen-Pi] Buddhist Tzu Chi Med Fdn, Dalin Tzu Chi Hosp, Dept Internal Med, Div Nephrol, Hualien 62247, Chiayi, Taiwan.
C3 Buddhist Tzu Chi General Hospital; Hualien Tzu Chi Hospital; Tzu Chi
   University; Tzu Chi University; Buddhist Tzu Chi General Hospital; Dalin
   Tzu Chi Hospital
RP Hsu, BG (corresponding author), Buddhist Tzu Chi Med Fdn, Hualien Tzu Chi Hosp, Div Nephrol, Hualien 97010, Taiwan.; Hsu, BG; Tsai, JP (corresponding author), Tzu Chi Univ, Sch Med, Hualien 97004, Taiwan.; Tsai, JP (corresponding author), Buddhist Tzu Chi Med Fdn, Dalin Tzu Chi Hosp, Dept Internal Med, Div Nephrol, Hualien 62247, Chiayi, Taiwan.
EM simianlkive@gmail.com; wangch33@gmail.com; hsienhsien@gmail.com;
   hermit.kuo@gmail.com; nomo8931126@gmail.com; gee.lily@msa.hinet.net;
   tsaininimd1491@gmail.com
RI Hsu, Bang-Gee/AAV-5287-2020
OI Hsu, Bang-Gee/0000-0001-9364-4558; Lai, Yu-Hsien/0000-0002-6687-1058;
   Kuo, Chiu huang/0000-0002-9239-6932
FU Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Taiwan
   [TCRD108-23, TCMF-MP 107-01-01]
FX This study was supported by a grant from Hualien Tzu Chi Hospital,
   Buddhist Tzu Chi Medical Foundation, Taiwan (TCRD108-23 and TCMF-MP
   107-01-01).
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NR 39
TC 21
Z9 21
U1 0
U2 3
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JUL
PY 2020
VL 12
IS 7
AR 2160
DI 10.3390/nu12072160
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA MS3ER
UT WOS:000554164400001
PM 32708072
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Hadi, A
   Alizadeh, K
   Hajianfar, H
   Mohammadi, H
   Miraghajani, M
AF Hadi, Amir
   Alizadeh, Kimia
   Hajianfar, Hossein
   Mohammadi, Hamed
   Miraghajani, Maryam
TI Efficacy of synbiotic supplementation in obesity treatment: A systematic
   review and meta-analysis of clinical trials
SO CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
LA English
DT Review
DE meta-analysis; obesity; overweight; synbiotic
ID BODY-MASS INDEX; FATTY LIVER-DISEASE; DOUBLE-BLIND; WEIGHT-LOSS;
   METABOLIC SYNDROME; OXIDATIVE STRESS; GUT MICROBIOTA; INFLAMMATORY
   MARKERS; NITRIC-OXIDE; PROBIOTICS
AB Several investigations have been reported the beneficial effects of synbiotic in participants with obesity, but these findings have been inconsistent. Therefore, we systematically reviewed available randomized clinical trials (RCTs) to elucidate the overall effects of synbiotic supplementation on anthropometric indices among participants with overweight or obesity. Five electronic databases including PubMed, Scopus, ISI Web of science, Cochrane Library and Google Scholar were searched up to October 2018. All RCTs using synbiotic supplements to treat obesity included in this systematic review and meta-analysis. Weighted mean difference (WMD) was pooled using a random-effects model. The present meta-analysis of 23 randomized trials indicated that supplementation with synbiotic can decrease body weight (WMD: -0.80 kg; 95% CI: -1.56 to -0.03, p = 0.04) and WC (WMD: -2.07 cm; 95% CI: -3.11 to -1.03, p < 0.001). In contrast, synbiotic did not have favorite effects on BMI (WMD: -0.12 kg/m(2); 95% CI: -0.40 to 0.16, p = 0.39) and body fat (WMD: 0.02%; 95% CI: -1.27 to 1.87, p = 0.74) compared with the placebo group. Meta-regression analyses revealed that the dosage of probiotic did not have any effect on anthropometric measures. Based on our findings, modulation of gut microbiota composition through synbiotic supplementation might have modest effects on body weight and waist circumference. In this field, however, our knowledge is progressing.
C1 [Hadi, Amir; Mohammadi, Hamed] Isfahan Univ Med Sci, Dept Clin Nutr, Students Res Comm, Sch Nutr & Food Sci, Esfahan, Iran.
   [Alizadeh, Kimia] Islamic Azad Univ, Sch Med, Med Branch Sarab, Sarab, Iran.
   [Hajianfar, Hossein] Semnan Univ Med Sci, Food Safety Res Ctr Salt, Semnan, Iran.
   [Hajianfar, Hossein] Semnan Univ Med Sci, Dept Nutr, Sch Nutr & Food Sci, Semnan, Iran.
   [Miraghajani, Maryam] Shahid Beheshti Univ Med Sci, Natl Nutr & Food Technol Res Inst, Tehran, Iran.
   [Miraghajani, Maryam] Univ Nottingham, Div Child Hlth Obstet & Gynaecol, Early Life Res Unit, Nottingham, England.
C3 Isfahan University of Medical Sciences; Islamic Azad University; Semnan
   University of Medical Sciences; Semnan University of Medical Sciences;
   Shahid Beheshti University Medical Sciences; University of Nottingham
RP Mohammadi, H; Miraghajani, M (corresponding author), Isfahan Univ Med Sci, Sch Nutr & Food Sci, Students Res Comm, POB 81745, Esfahan, Iran.
EM Mohammadihd@gmail.com; ms.miraghajani@yahoo.com
RI Hajianfar, Hossein/X-9443-2018; Hadi, Amir/AAK-4634-2020; Mohammadi,
   Hamed/Q-3166-2019
OI Miraghajani, Maryam/0000-0002-8265-0335
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NR 68
TC 52
Z9 52
U1 2
U2 37
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1040-8398
EI 1549-7852
J9 CRIT REV FOOD SCI
JI Crit. Rev. Food Sci. Nutr.
PD FEB 21
PY 2020
VL 60
IS 4
BP 584
EP 596
DI 10.1080/10408398.2018.1545218
PG 13
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA KC6DX
UT WOS:000507267000005
PM 30595036
DA 2025-06-11
ER

PT J
AU Barbe, A
   Bongrani, A
   Mellouk, N
   Estienne, A
   Kurowska, P
   Grandhaye, J
   Elfassy, Y
   Levy, R
   Rak, A
   Froment, P
   Dupont, J
AF Barbe, Alix
   Bongrani, Alice
   Mellouk, Namya
   Estienne, Anthony
   Kurowska, Patrycja
   Grandhaye, Jeremy
   Elfassy, Yaelle
   Levy, Rachel
   Rak, Agnieszka
   Froment, Pascal
   Dupont, Joelle
TI Mechanisms of Adiponectin Action in Fertility: An Overview from
   Gametogenesis to Gestation in Humans and Animal Models in Normal and
   Pathological Conditions
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE fertility; adipose tissue; reproductive tract; adipokines; cell
   signaling
ID POLYCYSTIC-OVARY-SYNDROME; MOLECULAR-WEIGHT ADIPONECTIN; MATERNAL SERUM
   ADIPONECTIN; HUMAN CEREBROSPINAL-FLUID; ACTIVATED PROTEIN-KINASE;
   ENDOMETRIAL CANCER-RISK; FULL-LENGTH ADIPONECTIN; EARLY 2ND TRIMESTER;
   FACTOR-KAPPA-B; PLASMA ADIPONECTIN
AB Adiponectin is the most abundant plasma adipokine. It mainly derives from white adipose tissue and plays a key role in the control of energy metabolism thanks to its insulin-sensitising, anti-inflammatory, and antiatherogenic properties. In vitro and in vivo evidence shows that adiponectin could also be one of the hormones controlling the interaction between energy balance and fertility in several species, including humans. Indeed, its two receptors-AdipoR1 and AdipoR2-are expressed in hypothalamic-pituitary-gonadal axis and their activation regulates Kiss, GnRH and gonadotropin expression and/or secretion. In male gonads, adiponectin modulates several functions of both somatic and germ cells, such as steroidogenesis, proliferation, apoptosis, and oxidative stress. In females, it controls steroidogenesis of ovarian granulosa and theca cells, oocyte maturation, and embryo development. Adiponectin receptors were also found in placental and endometrial cells, suggesting that this adipokine might play a crucial role in embryo implantation, trophoblast invasion and foetal growth. The aim of this review is to characterise adiponectin expression and its mechanism of action in male and female reproductive tract. Further, since features of metabolic syndrome are associated with some reproductive diseases, such as polycystic ovary syndrome, gestational diabetes mellitus, preeclampsia, endometriosis, foetal growth restriction and ovarian and endometrial cancers, evidence regarding the emerging role of adiponectin in these disorders is also discussed.
C1 [Barbe, Alix; Bongrani, Alice; Mellouk, Namya; Estienne, Anthony; Grandhaye, Jeremy; Froment, Pascal; Dupont, Joelle] INRA, UMR85, Physiol Reprod & Comportements, F-37380 Nouzilly, France.
   [Barbe, Alix; Bongrani, Alice; Mellouk, Namya; Estienne, Anthony; Grandhaye, Jeremy; Rak, Agnieszka; Froment, Pascal; Dupont, Joelle] CNRS, UMR7247, Physiol Reprod & Comportements, F-37380 Nouzilly, France.
   [Barbe, Alix; Bongrani, Alice; Mellouk, Namya; Estienne, Anthony; Grandhaye, Jeremy; Froment, Pascal; Dupont, Joelle] Univ Francois Rabelais Tours, F-37041 Tours, France.
   [Kurowska, Patrycja] Jagiellonian Univ, Inst Zool & Biomed Res, Dept Physiol & Toxicol Reprod, PL-31007 Krakow, Poland.
   [Elfassy, Yaelle; Levy, Rachel] Hop Tenon, AP HP, Serv Biol Reprod, F-75020 Paris, France.
   [Elfassy, Yaelle; Levy, Rachel] Univ Pierre & Marie Curie Paris 6, F-75005 Paris, France.
   [Elfassy, Yaelle; Levy, Rachel] INSERM, UMRS 938, Ctr Rech St Antoine, F-75571 Paris, France.
C3 INRAE; Centre National de la Recherche Scientifique (CNRS); CNRS -
   National Institute for Biology (INSB); Jagiellonian University;
   Assistance Publique Hopitaux Paris (APHP); Sorbonne Universite; Hopital
   Universitaire Tenon - APHP; Sorbonne Universite; Institut National de la
   Sante et de la Recherche Medicale (Inserm); Sorbonne Universite
RP Dupont, J (corresponding author), INRA, UMR85, Physiol Reprod & Comportements, F-37380 Nouzilly, France.; Dupont, J (corresponding author), CNRS, UMR7247, Physiol Reprod & Comportements, F-37380 Nouzilly, France.; Dupont, J (corresponding author), Univ Francois Rabelais Tours, F-37041 Tours, France.
EM alix.barbe@inra.fr; alice.bongrani@inra.fr; namya.mellouk@inra.fr;
   anthony.estienne@inra.fr; patrycja.kurowska@doctoral.uj.edu.pl;
   jeremy.grandhaye@inra.fr; yaelle.elfassy@hotmail.fr;
   rachel.levy@orange.fr; agnieszka.rak@uj.edu.pl; pascal.froment@inra.fr;
   Joelle.dupont@inra.fr
RI Mellouk, Namya/AAL-7583-2021; Bongrani, Alice/JCE-8274-2023
OI Kurowska, Patrycja/0000-0001-7634-0675; Rak,
   Agnieszka/0000-0002-9572-7151; Grandhaye, Jeremy/0000-0002-0909-837X;
   Bongrani, Alice/0000-0003-3730-4684
FU INRA; Val de Loire Region (France) [APR IR-2016]; grant Agence de
   Biomedecine "Obesite et qualite des spermatozoides humains: importance
   des adipocytokines"; Val de Loire Region (France)
FX This research was funded by INRA, Val de Loire Region (France), grant
   APR IR-2016 "PREVADI" and grant Agence de Biomedecine "Obesite et
   qualite des spermatozoides humains: importance des adipocytokines". A.
   Barbe and A. Bongrani were funded by Val de Loire Region (France).
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NR 255
TC 86
Z9 91
U1 2
U2 20
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD MAR 27
PY 2019
VL 20
IS 7
AR 1526
DI 10.3390/ijms20071526
PG 37
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA HU0SD
UT WOS:000464980400011
PM 30934676
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Yener, Y
   Yerlikaya, FH
AF Yener, Yesim
   Yerlikaya, Fatma Humeyra
TI Western diet induces endogen oxidative deoxyribonucleic acid damage and
   inflammation in Wistar rats
SO REVISTA DE NUTRICAO-BRAZILIAN JOURNAL OF NUTRITION
LA English
DT Article
DE Apoptosis; Deoxyribonucleic acid; Inflammation; Diet western; Oxidative
   stress damage
ID PLASMINOGEN-ACTIVATOR RECEPTOR; KAPPA-B ACTIVATION; HIGH-FAT;
   DNA-DAMAGE; DISEASE; POLYMERASE; BIOMARKER; SUCROSE; YKL-40; TISSUE
AB Objective
   Nutritional diseases such as metabolic syndrome, cardiovascular disorder, chronic inflammation or even cancer are observed in people who sustain their lifestyle by Western diet due to high calorie intake. The origin of these diseases are the degraded deoxyribonucleic acid structure. In this study, we investigated whether Western diet produced endogenous oxidative deoxyribonucleic acid damage, apoptosis or inflammation.
   Methods
   Twenty-eight male Wistar rats, aged 10-12 weeks, were divided into four groups. The rats in control group received the standard diet and the remaining rats were given one of the following three diets for four weeks: a high-fat diet containing 35% fat, a high-sucrose diet containing 69% sucrose and Western diet comprising both two types of diets. After treatment the serum 8-hydroxy-2-deoxyguanosine, poly (adenosine diphosphate ribose) polymerase-1, chitinase-3-like protein 1, soluble urokinase-type plasminogen activator receptor, Fas ligand and cytochrome c levels were measured.
   Results
   It was observed no changes in the serum soluble urokinase-type plasminogen activator receptor, Fas ligand and cytochrome c levels whereas a statistically significant increase in the serum 8-hydroxy-2-deoxyguanosine, poly (adenosine diphosphate ribose) polymerase-1 and chitinase-3-like protein 1 levels were found only in rats that were given Western diet.
   Conclusion
   The findings show that Western diet produced endogenous oxidative deoxyribonucleic acid damage, which then increased serum poly (adenosine diphosphate ribose) polymerase-1 levels, eventually leading to inflammation.
C1 [Yener, Yesim] Abant Izzet Baysal Univ, Fac Educ, Dept Elementary Educ, TR-14300 Golkoy, Bolu, Turkey.
   [Yerlikaya, Fatma Humeyra] Necmettin Erbakan Univ, Dept Biochem, Meram Fac Med, TR-42080 Meram, Konya, Turkey.
C3 Abant Izzet Baysal University; Necmettin Erbakan University
RP Yener, Y (corresponding author), Abant Izzet Baysal Univ, Fac Educ, Dept Elementary Educ, TR-14300 Golkoy, Bolu, Turkey.
EM yesimyener77@gmail.com
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NR 47
TC 0
Z9 0
U1 0
U2 2
PU PONTIFICIA UNIVERSIDADE CATOLICA CAMPINAS
PI CAMPINAS
PA NUCLEO EDITORACAO SBI-CCV, CAMPUS II AV JOHN BOYD DUNLOP S-N PREDIO
   ONTOLOGIA JD IPAUSSURAMA, CAMPINAS, SP 13060-904, BRAZIL
SN 1415-5273
J9 REV NUTR
JI Rev. Nutr.
PD MAY-JUN
PY 2018
VL 31
IS 3
BP 263
EP 273
DI 10.1590/1678-98652018000300001
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA GV7WL
UT WOS:000446344500001
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Simbulan, RK
   Liu, X
   Feuer, SK
   Maltepe, E
   Donjacour, A
   Rinaudo, P
AF Simbulan, R. K.
   Liu, X.
   Feuer, S. K.
   Maltepe, E.
   Donjacour, A.
   Rinaudo, P.
TI Adult male mice conceived by in vitro fertilization exhibit
   increased glucocorticoid receptor expression in fat tissue
SO JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE
LA English
DT Article
DE assisted reproductive techonologies; developmental programming;
   glucocorticoid hormones; glucocorticoid receptor; in vitro fertilization
ID PREIMPLANTATION MOUSE EMBRYOS; PITUITARY-ADRENAL AXIS; GENE-EXPRESSION;
   METABOLIC SYNDROME; DEVELOPMENTAL ORIGINS; MAMMALIAN DEVELOPMENT;
   MOLECULAR-MECHANISMS; PRENATAL STRESS; CHILDREN BORN; FETAL ORIGINS
AB Prenatal development is highly plastic and readily influenced by the environment. Adverse conditions have been shown to alter organ development and predispose offspring to chronic diseases, including diabetes and hypertension. Notably, it appears that the changes in glucocorticoid hormones or glucocorticoid receptor (GR) levels in peripheral tissues could play a role in the development of chronic diseases. We have previously demonstrated that in vitro fertilization (IVF) and preimplantation embryo culture is associated with growth alterations and glucose intolerance in mice. However, it is unknown if GR signaling is affected in adult IVF offspring. Here we show that GR expression is increased in inbred (C57Bl6/J) and outbred (CF-1 x B6D2F1/J) blastocysts following in vitro culture and elevated levels are also present in the adipose tissue of adult male mice. Importantly, genes involved in lipolysis and triglyceride synthesis and responsive to GR were also increased in adipose tissue, indicating that increased GR activates downstream gene pathways. The promoter region of GR, previously reported to be epigenetically modified by perinatal manipulation, showed no changes in DNA methylation status. Our findings demonstrate that IVF results in a long-term change in GR gene expression in a sex-and tissue-specific manner. These changes in adipose tissues may well contribute to the metabolic phenotype in mice conceived by IVF.
C1 [Simbulan, R. K.; Liu, X.; Feuer, S. K.; Donjacour, A.; Rinaudo, P.] Univ Calif San Francisco, Dept Obstet Gynecol & Reprod Sci, San Francisco, CA USA.
   [Maltepe, E.] Univ Calif San Francisco, Dept Pediat, San Francisco, CA USA.
   [Donjacour, A.] Univ Calif San Francisco, Dept Anat, San Francisco, CA 94143 USA.
C3 University of California System; University of California San Francisco;
   University of California System; University of California San Francisco;
   University of California System; University of California San Francisco
RP Rinaudo, P (corresponding author), Div Reprod Endocrinol & Infertil, 513 Parnassus Ave,HSW 1463E, San Francisco, CA 94143 USA.
EM Paolo.Rinaudo@ucsf.edu
FU National Institute of Child Health and Human Development grant [R01:HD
   062803-01A1]; National Institute of Health [5T32DK007418-32]; California
   Institute for Regenerative Medicine [TB1-01194]; National Institute of
   Diabetes and Digestive and Kidney Diseases [T32DK007418] Funding Source:
   NIH RePORTER
FX This work was supported by a National Institute of Child Health and
   Human Development grant (R01:HD 062803-01A1) and in part by a National
   Institute of Health training fellowship (5T32DK007418-32, for S.K.F.)
   and the California Institute for Regenerative Medicine (TB1-01194, for
   R.K.S.).
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NR 53
TC 13
Z9 13
U1 0
U2 3
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 2040-1744
EI 2040-1752
J9 J DEV ORIG HLTH DIS
JI J. Dev. Orig. Health Dis.
PD FEB
PY 2016
VL 7
IS 1
BP 73
EP 82
DI 10.1017/S2040174415007825
PG 10
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA CZ7FC
UT WOS:000367264300010
PM 26511158
DA 2025-06-11
ER

PT J
AU Shortliffe, LMD
   Hammam, O
   Han, XY
   Kouba, E
   Tsao, PS
   Wang, BY
AF Shortliffe, Linda M. Dairiki
   Hammam, Olfat
   Han, Xiaoyuan
   Kouba, Erik
   Tsao, Philip S.
   Wang, Bingyin
TI Dietary fructose in pregnancy induces hyperglycemia, hypertension, and
   pathologic kidney and liver changes in a rodent model
SO PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR
   HEALTH
LA English
DT Article
DE Fructose; Hyperglycemia; Hypertension; Diabetes; Pregnancy
ID SPRAGUE-DAWLEY RATS; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   BLOOD-PRESSURE; SOFT DRINKS; DISEASE; CONSUMPTION; BEVERAGES; SUCROSE
AB Purpose: The incidence of pregnancies complicated by hyperglycemia and hypertension is increasing along with associated morbidities to mother and offspring. The high fructose diet is a well-studied model that induces hyperglycemia and hypertension in male rodents, but may not affect females. We hypothesized that the physiologic stress of pregnancy may alter metabolic responses to dietary fructose.
   Materials and methods: In this study female Sprague-Dawley rats were divided into two gestational dietary groups: (1) 60% carbohydrate standard rat chow (Pregnant-S-controls) and (2) 60% fructose enriched chow (Pregnant-F). Body weight, blood pressure, blood glucose, triglycerides, and insulin were measured in pregnancy and during the post-partum period. Maternal organ weight and histological changes were also assessed after delivery.
   Results: By midpregnancy Pregnant-F rats had increased weight, elevated blood pressure, higher fasting glucose, and elevated triglycerides compared with Pregnant-S rats. Both groups demonstrated elevated gestational insulin levels with signs of insulin resistance (increased HOMA-IR). Pregnant-F rats showed significant histopathologic hepatic steatosis and renal tubular changes characterized by tubular dilation and glomerulosclerosis.
   Conclusion: Our study provides a model in which dietary change during pregnancy can be examined. We demonstrate, moreover, that high dietary fructose ingestion in pregnant rats may result in profound systemic and pathologic changes not appreciated during routine pregnancy. (C) 2015 International Society for the Study of Hypertension in Pregnancy. Published by Elsevier B.V. All rights reserved.
C1 [Shortliffe, Linda M. Dairiki; Hammam, Olfat; Han, Xiaoyuan; Kouba, Erik; Wang, Bingyin] Stanford Univ, Dept Urol, Sch Med, Stanford, CA 94305 USA.
   [Tsao, Philip S.] Stanford Univ, Sch Med, Dept Med, Stanford, CA 94305 USA.
C3 Stanford University; Stanford University
RP Shortliffe, LMD (corresponding author), Dept Urol, Pediat Urol, 750 Welch Rd,Suite 218, Stanford, CA 94305 USA.
EM lindashortliffe@stanford.edu; totoali1@hotmail.com;
   erikjkouba@gmail.com; ptsao@stanford.edu; bingyin49@gmail.com
RI Han, Xiaoyuan/AAY-1974-2020; Hammam, Olfat/D-4613-2015; Wang,
   Bingyin/G-9992-2011
OI kouba, erik/0000-0001-5430-8850; Hammam, Olfat/0000-0002-4965-5804;
   Tsao, Philip/0000-0001-7274-9318
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NR 30
TC 17
Z9 20
U1 0
U2 10
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 2210-7789
J9 PREGNANCY HYPERTENS
JI Pregnancy Hypertens.
PD OCT
PY 2015
VL 5
IS 4
BP 308
EP 314
DI 10.1016/j.preghy.2015.08.002
PG 7
WC Obstetrics & Gynecology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology; Cardiovascular System & Cardiology
GA CY0EG
UT WOS:000366078600010
PM 26597746
DA 2025-06-11
ER

PT J
AU Gouni-Berthold, I
   Berthold, HK
AF Gouni-Berthold, Ioanna
   Berthold, Heiner K.
TI The Role of Niacin in Lipid-lowering Treatment: Are we Aiming Too High?
SO CURRENT PHARMACEUTICAL DESIGN
LA English
DT Article
DE Niacin; nicotinic acid; lipids; lipoproteins; lipid-lowering drugs;
   statins; laropiprant
ID EXTENDED-RELEASE NIACIN; RECEPTOR 1 ANTAGONIST; CORONARY STENOSIS
   PROGRESSION; HEALED MYOCARDIAL-INFARCTION; LOW HDL CHOLESTEROL;
   APOLIPOPROTEIN-A-I; NICOTINIC-ACID; PROSTAGLANDIN D-2; METABOLIC
   SYNDROME; HEART-DISEASE
AB The clinically most relevant medications for lipid management are the statins, which constitute in the majority of the cases the basis of any lipid-modulating therapy. However, other agents are often needed to either reduce low-density cholesterol to target levels and/or to treat residual serum lipoprotein abnormalities. Niacin is currently the most potent available agent to increase high-density lipoprotein and reduce lipoprotein(a), both independent risk factors for cardiovascular disease. Niacin also has been found to reduce inflammatory markers like C-reactive protein (CRP) and lipoprotein-associated phospholipase-A2 (Lp-PLA2) and to decrease small-dense LDL and increase large-particle LDL, all potentially anti-atherosclerotic properties. Through its action on the GPR109A receptor niacin seems to also exert various pleiotropic effects such as improvement of endothelial function and reduction of inflammation and oxidative stress. However, niacin is often underused in the clinical setting, mainly due to either potentially preventable or disproportionally feared side effects such as flushing, hyperglycemia, and hyperuricemia, respectively. Even though the results of the AIM-HIGH trial were negative, the results of the larger end point trial HPS2-THRIVE are still pending. Based on the totality of existing evidence, niacin should in the mean time remain high in the list of lipid-modulating agents to be used in clinical practice, second after statins.
C1 [Gouni-Berthold, Ioanna] Univ Cologne, Ctr Endocrinol Diabet & Prevent Med, D-50937 Cologne, Germany.
   [Berthold, Heiner K.] Charite, Virchow Clin Campus, Lipid Clin, Interdisciplinary Metab Ctr, D-13353 Berlin, Germany.
   [Berthold, Heiner K.] Charite, Evangel Geriatr Ctr Berlin EGZB, D-13353 Berlin, Germany.
C3 University of Cologne; Berlin Institute of Health; Free University of
   Berlin; Humboldt University of Berlin; Charite Universitatsmedizin
   Berlin; Berlin Institute of Health; Free University of Berlin; Humboldt
   University of Berlin; Charite Universitatsmedizin Berlin
RP Gouni-Berthold, I (corresponding author), Univ Cologne, Ctr Endocrinol Diabet & Prevent Med, Kerpener St 62, D-50937 Cologne, Germany.
EM ioanna.berthold@uni-koeln.de
RI Berthold, Heiner/E-6017-2011
OI Berthold, Heiner/0000-0002-1457-2216
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NR 128
TC 13
Z9 16
U1 0
U2 17
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1381-6128
EI 1873-4286
J9 CURR PHARM DESIGN
JI Curr. Pharm. Design
PD MAY
PY 2013
VL 19
IS 17
BP 3094
EP 3106
PG 13
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 119DH
UT WOS:000317077100017
PM 23317400
DA 2025-06-11
ER

PT J
AU Kim, YL
   Cho, JH
   Choi, JY
   Kim, CD
   Park, SH
AF Kim, Yong-Lim
   Cho, Jang-Hee
   Choi, Ji-Young
   Kim, Chan-Duck
   Park, Sun-Hee
TI Systemic and Local Impact of Glucose and Glucose Degradation Products in
   Peritoneal Dialysis Solution
SO JOURNAL OF RENAL NUTRITION
LA English
DT Article
ID 3,4-DIDEOXYGLUCOSONE-3-ENE INDUCES APOPTOSIS; RESIDUAL RENAL-FUNCTION;
   MESENCHYMAL TRANSITION; MAINTENANCE DIALYSIS; NONDIABETIC PATIENTS;
   METABOLIC SYNDROME; DIABETES-MELLITUS; MESOTHELIAL CELLS;
   MEMBRANE-FUNCTION; INFUSION MODEL
AB The main osmotic agent used in the peritoneal dialysis (PD) solution is glucose because of its great osmotic power, simple metabolism, and safety. Once into the systemic circulation, however, glucose can be a cause for metabolic complications including hyperglycemia, obesity, and dyslipidemia. The glucose absorbed from peritoneal cavity leads to insulin resistance and hyperglycemia, which is associated with oxidative stress. Long-term exposure of peritoneal membrane to glucose in PD solution also has local effects such as functional and structural changes leading to peritoneal membrane failure. Moreover, the intraperitoneal glucose absorption induces conditions similar to postprandial hyperglycemia, which is a proven independent risk factor of coronary artery disease in patients with type 2 diabetes. Though speculative, glucose toxicity might explain a higher mortality of PD patients after the first few years compared with those on hemodialysis. Glucose degradation products (GDPs) induce apoptosis of peritoneal mesothelial cells (PMCs), renal tubular epithelial cells, and endothelial cells, and facilitating epithelial mesenchymal transition of PMCs. GDPs provide a stronger reactivity than glucose in the formation of advanced glycation end-products, a known cause for microvascular complications and arteriosclerosis. Unfortunately, clinical studies using a low-GDP PD solution have provided mixed results on the residual renal function, peritonitis, peritoneal membrane function, and mortality; consistent outcome data are not readily available at present. (C) 2013 by the National Kidney Foundation, Inc. All rights reserved.
C1 [Kim, Yong-Lim; Cho, Jang-Hee; Choi, Ji-Young; Kim, Chan-Duck; Park, Sun-Hee] Kyungpook Natl Univ Hosp, Clin Res Ctr End Stage Renal Dis, Dept Internal Med, Taegu, South Korea.
C3 Kyungpook National University (KNU); Kyungpook National University
   Hospital (KNUH)
RP Kim, YL (corresponding author), Kyungpook Natl Univ Hosp, Dept Internal Med, 130 Dongdeok Ro, Taegu 700721, South Korea.
EM ylkim@knu.ac.kr
RI Park, Sun-Hee/LMN-0033-2024; Cho, Jang-hee/ABD-3534-2020; Kim,
   Yong-Lim/AGK-3172-2022
FU Ministry for Health, Welfare and Family Affairs, Republic of Korea
   [A102065]
FX This study was supported with a grant from the Korea Healthcare
   Technology Research and Development Project, Ministry for Health,
   Welfare and Family Affairs, Republic of Korea (A102065). This manuscript
   was written for the ISRNM Hawaii Congress Proceedings (JReN Congress
   Special Edition, May 2013 issue).
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NR 58
TC 22
Z9 24
U1 0
U2 12
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 1051-2276
J9 J RENAL NUTR
JI J. Renal Nutr.
PD MAY
PY 2013
VL 23
IS 3
BP 218
EP 222
DI 10.1053/j.jrn.2013.01.019
PG 5
WC Nutrition & Dietetics; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics; Urology & Nephrology
GA 147XF
UT WOS:000319203500017
PM 23510669
DA 2025-06-11
ER

PT J
AU Roth, RJ
   Le, AM
   Zhang, L
   Kahn, M
   Samuel, VT
   Shulman, GI
   Bennett, AM
AF Roth, Rachel J.
   Le, Annie M.
   Zhang, Lei
   Kahn, Mario
   Samuel, Varman T.
   Shulman, Gerald I.
   Bennett, Anton M.
TI MAPK phosphatase-1 facilitates the loss of oxidative myofibers
   associated with obesity in mice
SO JOURNAL OF CLINICAL INVESTIGATION
LA English
DT Article
ID MUSCLE MITOCHONDRIAL-FUNCTION; FATTY-ACID OXIDATION; SKELETAL-MUSCLE;
   INSULIN-RESISTANCE; PGC-1-ALPHA TRANSCRIPTION; COACTIVATOR PGC-1-ALPHA;
   DIFFERENTIAL REGULATION; KINASE-ACTIVITY; FIBER-TYPE; PROTEIN
AB Oxidative myofibers, also known as slow-twitch myofibers, help maintain the metabolic health of mammals, and it has been proposed that decreased numbers correlate with increased risk of obesity. The transcriptional coactivator PPAR gamma coactivator 1 alpha (PGC-1 alpha) plays a central role in maintaining levels of oxidative myofibers in skeletal muscle. Indeed, loss of PGC-1 alpha expression has been linked to a reduction in the proportion of oxidative myofibers in the skeletal muscle of obese mice. MAPK phosphatase-1 (MKP-1) is encoded by mkp-1, a stress-responsive immediate-early gene that dephosphorylates MAPKs in the nucleus. Previously we showed that mice deficient in MKP-1 have enhanced energy expenditure and are resistant to diet-induced obesity. Here we show in mice that excess dietary fat induced MKP-1 overexpression in skeletal muscle, and that this resulted in reduced p38 MAPK-mediated phosphorylation of PGC-1 alpha on sites that promoted its stability. Consistent with this, MKP-1-deficient mice expressed higher levels of PGC-1 alpha in skeletal muscle than did wild-type mice and were refractory to the loss of oxidative myofibers when fed a high-fat diet. Collectively, these data demonstrate an essential role for MKP-1 as a regulator of the myofiber composition of skeletal muscle and suggest a potential role for MKP-1 in metabolic syndrome.
C1 [Roth, Rachel J.; Le, Annie M.; Zhang, Lei; Bennett, Anton M.] Yale Univ, Sch Med, Dept Pharmacol, New Haven, CT 06520 USA.
   [Kahn, Mario; Samuel, Varman T.; Shulman, Gerald I.] Yale Univ, Sch Med, Dept Cellular & Mol Physiol, New Haven, CT 06520 USA.
   [Samuel, Varman T.] Yale Univ, Sch Med, Dept Internal Med, Sect Endocrinol & Metab, New Haven, CT 06520 USA.
   [Shulman, Gerald I.] Yale Univ, Sch Med, Howard Hughes Med Inst, New Haven, CT 06520 USA.
C3 Yale University; Yale University; Yale University; Howard Hughes Medical
   Institute; Yale University
RP Bennett, AM (corresponding author), Yale Univ, Sch Med, Dept Pharmacol, SHM B226D,333 Cedar St, New Haven, CT 06520 USA.
EM anton.bennett@yale.edu
RI Shulman, Gerald/P-7176-2019; Bennett, Anton/JGD-0863-2023
OI Shulman, Gerald/0000-0003-1529-5668; Bennett, Anton/0000-0001-5187-7599
FU PhRMA Foundation; NIH [T32 DK07356, P30 DK4S73S, U24 DK-76169]; VA Merit
   Award
FX We thank Leslie Leinwand for MHCIIX monoclonal antibody and Bruce
   Spiegelman for PGC-1 alpha plasmids. This work was supported by the
   PhRMA Foundation and NIH grant T32 DK07356 to R.J. Roth; by NIH grants
   AR46524 and DK7S776 to A.M. Bennett; by NIH grants DK40936, P30 DK4S73S,
   and U24 DK-76169 to G.I. Shulman; and by a VA Merit Award to V.T.
   Samuel.
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NR 62
TC 54
Z9 61
U1 0
U2 6
PU AMER SOC CLINICAL INVESTIGATION INC
PI ANN ARBOR
PA 2015 MANCHESTER RD, ANN ARBOR, MI 48104 USA
SN 0021-9738
EI 1558-8238
J9 J CLIN INVEST
JI J. Clin. Invest.
PD DEC
PY 2009
VL 119
IS 12
BP 3817
EP 3829
DI 10.1172/JCI39054
PG 13
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 527SI
UT WOS:000272386400029
PM 19920356
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Risler, NR
   Cruzado, MC
   Miatello, RM
AF Risler, Norma R.
   Cruzado, Montserrat C.
   Miatello, Roberto M.
TI Vascular remodeling in experimental hypertension
SO THESCIENTIFICWORLDJOURNAL
LA English
DT Article
DE vascular wall; vascular remodeling; experimental hypertension
ID NITRIC-OXIDE SYNTHASE; SMOOTH-MUSCLE-CELLS; RENIN-ANGIOTENSIN SYSTEM;
   RESISTANCE ARTERIES; EXTRACELLULAR-MATRIX; PROTEOGLYCANS PRODUCTION;
   ENDOTHELIAL DYSFUNCTION; CARDIOVASCULAR CHANGES; OXIDATIVE STRESS;
   NAD(P)H OXIDASE
AB The basic hemodynamic abnormality in hypertension is an increased peripheral resistance that is due mainly to a decreased vascular lumen derived from structural changes in the small arteries wall, named (as a whole) vascular remodeling. The vascular wall is an active, flexible, and integrated organ made up of cellular (endothelial cells, smooth muscle cells, adventitia cells, and fibroblasts) and noncellular (extracellular matrix) components, which in a dynamic way change shape or number, or reorganize in response to physiological and pathological stimuli, maintaining the integrity of the vessel wall in physiological conditions or participating in the vascular changes in cardiovascular diseases such as hypertension. Research focused on new signaling pathways and molecules that can participate in the mechanisms of vascular remodeling has provided evidence showing that vascular structure is not only affected by blood pressure, but also by mechanisms that are independent of the increased pressure. This review will provide an overview of the evidence, explaining some of the pathophysiologic mechanisms participating in the development of the vascular remodeling, in experimental models of hypertension, with special reference to the findings in spontaneously hypertensive rats as a model of essential hypertension, and in fructose-fed rats as a model of secondary hypertension, in the context of the metabolic syndrome. The understanding of the mechanisms producing the vascular alterations will allow the development of novel pharmacological tools for vascular protection in hypertensive disease.
C1 Univ Nacl Cuyo, Ctr Univ, Dept Pathol, Sch Med Sci, RA-5500 Mendoza, Argentina.
   Univ Nacl Cuyo, Ctr Univ, Dept Morphophysiol, Sch Med Sci, RA-5500 Mendoza, Argentina.
C3 University Nacional Cuyo Mendoza; University Nacional Cuyo Mendoza
RP Risler, NR (corresponding author), Univ Nacl Cuyo, Ctr Univ, Dept Pathol, Sch Med Sci, RA-5500 Mendoza, Argentina.
EM nrisler@fcm.uncu.edu.ar; mcruzado@fcm.uncu.edu.ar;
   rmiatell@fcm.uncu.edu.ar
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NR 78
TC 13
Z9 15
U1 2
U2 9
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1537-744X
J9 THESCIENTIFICWORLDJO
JI TheScientificWorldJOURNAL
PD DEC
PY 2005
VL 5
BP 959
EP 971
DI 10.1100/tsw.2005.122
PG 13
WC Environmental Sciences; Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Science & Technology - Other Topics
GA 110NQ
UT WOS:000242386000004
PM 16362087
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT S
AU Horiuchi, S
   Unno, Y
   Usui, H
   Shikata, K
   Takaki, K
   Koita, W
   Sakamoto, YI
   Nagai, R
   Makino, K
   Sasao, A
   Wada, J
   Makino, H
AF Horiuchi, S
   Unno, Y
   Usui, H
   Shikata, K
   Takaki, K
   Koita, W
   Sakamoto, YI
   Nagai, R
   Makino, K
   Sasao, A
   Wada, J
   Makino, H
BE Baynes, JW
   Monnier, VM
   Ames, JM
   Thorpe, SR
TI Pathological roles of advanced glycation end product receptors SR-A and
   CD36
SO MAILLARD REACTION: CHEMISTRY AT THE INTERFACE OF NUTRITION, AGING, AND
   DISEASE
SE ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
LA English
DT Article; Proceedings Paper
CT 8th International Symposium on the Maillard Reaction
CY AUG 29-SEP 01, 2004
CL Charleston, SC
SP Asahi Kasei Pharma, Avents, BASF, Biostratum, Univ S Carolina, Coll Sci & Math, Danisco, Danone Vitapole, Ctr Rech Daniel Carasso, DSM, Estee Lauder Co, Inlight Solut, IUBMB, Juvenile Diabet Res Fdn, KOWA, Oregon State Univ, Linus Pauling Inst, LOreal, Med Univ S Carolina, Merck, NIA, Nestle, Renascience, Univ S Carolina, Res & Hlth Sci, Taisho Pharmaceut Co Ltd, UNILEVER
DE SR-A; AGE receptor; CD36; adipocytes; leptin; oxidized LDL
ID LOW-DENSITY-LIPOPROTEIN; MACROPHAGE SCAVENGER RECEPTORS; ENDOTHELIAL
   RECEPTOR; ENDOCYTIC UPTAKE; ATHEROSCLEROSIS; PROTEINS; AGE; EXPRESSION;
   BINDING; CLONING
AB The pathological significance of advanced glycation end product (AGE)-modified proteins deposited in several lesions is generally accounted for by their cellular interaction via the AGE receptors and subsequent acceleration of the inflammatory process. In this study, we focused on two AGE receptors-specifically, the role of SR-A in pathogenesis of diabetic nephropathy and the role of CD36 in AGE-induced downregulation of leptin by adipocytes. In terms of SR-A, diabetic wild-type mice exhibited increased urinary albumin excretion, glomerular hypertrophy, and mesangial matrix expansion, whereas SR-A-knockout mice showed reduced glomerular size and mesangial matrix area. In these diabetic SR-A-knockout mice, the number of macrophages that infiltrated into glomeruli was remarkably reduced (P < 0.05), suggesting that SR-A-dependent glomerular migration of macrophages plays an important role in the pathogenesis of diabetic nephropathy. In terms of CD36, incubation of glycolaldehyde-modified bovine serum albumin (GA-BSA) with 3T3-L1 adipocytes reduced leptin secretion by these cells. The binding of GA-BSA to these cells and subsequent endocytic degradation were effectively inhibited by a neutralizing anti-CD36 antibody. AGE-induced downregulation of leptin was protected by N-acetyl-cysteine, an antioxidant. These results indicate that the interaction of AGE ligands with 3T3-L1 adipocytes via CD36 induces oxidative stress and leads to inhibition of leptin expression by these cells, suggesting a potential link of this phenomenon to exacerbation of the insulin sensitivity in metabolic syndrome.,
C1 Kumamoto Univ, Grad Sch Med & Pharmaceut Sci, Dept Med Biochem, Kumamoto 8608556, Japan.
   Okayama Univ, Grad Sch Med & Dent, Dept Med & Clin Sci, Okayama 7008530, Japan.
C3 Kumamoto University; Okayama University
RP Horiuchi, S (corresponding author), Kumamoto Univ, Grad Sch Med & Pharmaceut Sci, Dept Med Biochem, Honjo 1-1-1, Kumamoto 8608556, Japan.
EM horiuchi@gpo.kumamoto-u.ac.jp
RI ; Wada, Jun/B-2023-2011
OI UNNO, YUKA/0000-0002-9877-0200; Wada, Jun/0000-0003-1468-5170; Takaki,
   Kaori/0009-0003-1494-5267
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NR 24
TC 34
Z9 39
U1 0
U2 6
PU NEW YORK ACAD SCIENCES
PI NEW YORK
PA 2 EAST 63RD ST, NEW YORK, NY 10021 USA
SN 0077-8923
BN 1-57331-531-1
J9 ANN NY ACAD SCI
JI Ann.NY Acad.Sci.
PY 2005
VL 1043
BP 671
EP 675
DI 10.1196/annals.1333.076
PG 5
WC Biochemistry & Molecular Biology; Chemistry, Applied; Multidisciplinary
   Sciences; Physiology
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry; Science & Technology -
   Other Topics; Physiology
GA BCY08
UT WOS:000231834100076
PM 16037291
DA 2025-06-11
ER

PT J
AU Rivas, MA
   Matteucci, EA
   Rodriguez, IF
   Moreno, MA
   Zampini, IC
   Ramon, A
   Isla, MI
AF Rivas, Marisa Ayelen
   Matteucci, Enzo Agustin
   Rodriguez, Ivana Fabiola
   Moreno, Maria Alejandra
   Zampini, Iris Catiana
   Ramon, Adriana
   Isla, Maria Ines
TI Nutritional and Functional Characterization of Flour from Seeds of
   Chañar (Geoffroea decorticans) to Promote Its Sustainable Use
SO PLANTS-BASEL
LA English
DT Article
DE cha & ntilde;ar; nutritional; functional properties; antioxidant;
   antilipoxygenase; alpha-amylase; alpha-glucosidase
ID ACUTE TOXICITY; CRANBERRY PROANTHOCYANIDINS; METABOLIC SYNDROME;
   OXIDATIVE STRESS; ARTEMIA-SALINA; POLYPHENOLS; FRUIT; ENZYMES;
   INHIBITION; EXTRACTS
AB Geoffroea decorticans (Gill. ex Hook. & Arn) Burk. is a native tree of the dry areas of Northwestern and Central Argentina. Its seeds are considered waste material. The flour of seeds was analyzed as a source of nutritional and bioactive compounds. It has a low carbohydrate content, containing about 9% protein and between 10 and 14% fat. Approximately 82-84% of the fatty acids were unsaturated (oleic and linoleic acids). A high polyphenol and dietary fiber content was detected. Flavonoids and condensed tannins were the dominant phenolics. Polyphenol-enriched extracts were obtained from seed flour. The HPLC-ESI-MS/MS analysis of these concentrated extracts allowed for the identification of six compounds including C-glycosyl flavones (vitexin and isovitexin), type A procyanidins (dimer and trimer), and epicatequin gallate. Polyphenolic extracts showed antioxidant capacity and were able to inhibit enzymes (alpha-glucosidase and alpha-amylase) related to carbohydrate metabolism and (lipoxygenase) pro-inflammatory enzymes and were not toxic. Flour and polyphenolic extract from cha & ntilde;ar seeds could be considered as new alternative ingredients for the formulation of functional foods, nutraceuticals, or food supplements. The use of the seed flour in addition to the pulp of the fruit along with the rest of the plant would encourage the propagation of this species resistant to extreme arid environments for commercial and conservation purposes to boost the regional economies of vulnerable areas of South America.
C1 [Rivas, Marisa Ayelen; Matteucci, Enzo Agustin; Rodriguez, Ivana Fabiola; Moreno, Maria Alejandra; Zampini, Iris Catiana; Isla, Maria Ines] UNT, CONICET, Inst Bioprospecc & Fisiol Vegetal INBIOFIV, RA-T4000CBG San Miguel De Tucuman, Argentina.
   [Rivas, Marisa Ayelen] Univ Nacl Salta UNSa, Fac Ciencias Salud, Catedra Biol Celular Genet & Embriol, Ave Bolivia 5150, RA-A4400 Salta, Argentina.
   [Rodriguez, Ivana Fabiola; Zampini, Iris Catiana; Isla, Maria Ines] Univ Nacl Tucuman UNT, Fac Ciencias Nat IML, RA-T4000JFE San Miguel De Tucuman, Argentina.
   [Ramon, Adriana] Univ Nacl Salta UNSa, Fac Ciencias Salud, Lab Alimentos, Ave Bolivia 5150, RA-A4400 Salta, Argentina.
C3 Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET);
   Universidad Nacional de Tucuman
RP Isla, MI (corresponding author), UNT, CONICET, Inst Bioprospecc & Fisiol Vegetal INBIOFIV, RA-T4000CBG San Miguel De Tucuman, Argentina.; Isla, MI (corresponding author), Univ Nacl Tucuman UNT, Fac Ciencias Nat IML, RA-T4000JFE San Miguel De Tucuman, Argentina.
EM maarisarivas@gmail.com; matteucci_agustin@hotmail.com;
   fabiolarodriguez@csnat.unt.edu.ar; alejandramoreno@conicet.gov.ar;
   zampini@csnat.unt.edu.ar; adrianayricardo@gmail.com;
   misla@csnat.unt.edu.ar
FU Universidad Nacional de Tucuman [PIUNT 2018-G637]; Agencia Nacional de
   Promocion Cientifica y Tecnica (ANPCyT) [PICT 2020-3619,
   PICT-2021-CAT-II-00132]; Consejo Nacional de Investigaciones Cientificas
   y Tecnicas (CONICET) [PUE 2018-0011]; Fundacion Williams 2023; Fondos
   complementarios para proyectos de investigacion con impacto en el
   territorio argentino; Biolates network [P320RT0186]
FX This research was funded by Universidad Nacional de Tucuman (PIUNT
   2018-G637 Project), Agencia Nacional de Promocion Cientifica y Tecnica
   (ANPCyT PICT 2020-3619; PICT-2021-CAT-II-00132), Consejo Nacional de
   Investigaciones Cientificas y Tecnicas (CONICET-PUE 2018-0011),
   Fundacion Williams 2023. Fondos complementarios para proyectos de
   investigacion con impacto en el territorio argentino and Biolates
   network "P320RT0186-Sustainable use of Ibero-American vegetable biomass
   resources in cosmetics" (CYTED).
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NR 63
TC 0
Z9 0
U1 2
U2 2
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
SN 2223-7747
J9 PLANTS-BASEL
JI Plants-Basel
PD MAR 27
PY 2025
VL 14
IS 7
AR 1047
DI 10.3390/plants14071047
PG 18
WC Plant Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences
GA 1FG2V
UT WOS:001463628100001
PM 40219115
OA gold
DA 2025-06-11
ER

PT J
AU Schekatolina, S
   Lahovska, V
   Bekshaev, A
   Kontush, S
   Le Goff, W
   Kontush, A
AF Schekatolina, Svetlana
   Lahovska, Viktoriia
   Bekshaev, Aleksandr
   Kontush, Sergey
   Le Goff, Wilfried
   Kontush, Anatol
TI Mathematical Modelling of Material Transfer to High-Density Lipoprotein
   (HDL) upon Triglyceride Lipolysis by Lipoprotein Lipase: Relevance to
   Cardioprotective Role of HDL
SO METABOLITES
LA English
DT Article
DE mathematical modelling; lipolysis; triglyceride-rich lipoproteins;
   high-density lipoprotein; free cholesterol; lipoprotein lipase;
   triglycerides; intestine; atherosclerosis; cardiovascular disease
ID ESTER TRANSFER PROTEIN; ELEVATED OXIDATIVE STRESS; APOLIPOPROTEIN-A-I;
   CAUSE-SPECIFIC MORTALITY; SERUM HIGH-DENSITY; CHOLESTEROL EXCHANGE;
   CONSENSUS STATEMENT; METABOLIC SYNDROME; PARTICLES; MECHANISM
AB High-density lipoprotein (HDL) contributes to lipolysis of triglyceride-rich lipoprotein (TGRL) by lipoprotein lipase (LPL) via acquirement of surface lipids, including free cholesterol (FC), released upon lipolysis. According to the reverse remnant-cholesterol transport (RRT) hypothesis recently developed by us, acquirement of FC by HDL is reduced at both low and extremely high HDL concentrations, potentially underlying the U-shaped relationship between HDL-cholesterol and cardiovascular disease. Mechanisms underlying impaired FC transfer however remain indeterminate. We developed a mathematical model of material transfer to HDL upon TGRL lipolysis by LPL. Consistent with experimental observations, mathematical modelling showed that surface components of TGRL, including FC, were accumulated in HDL upon lipolysis. The modelling successfully reproduced major features of cholesterol accumulation in HDL observed experimentally, notably saturation of this process over time and appearance of a maximum as a function of HDL concentration. The calculations suggested that the both phenomena resulted from competitive fluxes of FC through the HDL pool, including primarily those driven by FC concentration gradient between TGRL and HDL on the one hand and mediated by lecithin-cholesterol acyltransferase (LCAT) and cholesteryl ester transfer protein (CETP) on the other hand. These findings provide novel opportunities to revisit our view of HDL in the framework of RRT.
C1 [Schekatolina, Svetlana; Lahovska, Viktoriia] Odessa Natl Technol Univ, UA-65000 Odessa, Ukraine.
   [Bekshaev, Aleksandr; Kontush, Sergey] Mechnikov Odessa Natl Univ, Phys Res Inst, UA-65082 Odessa, Ukraine.
   [Le Goff, Wilfried; Kontush, Anatol] Sorbonne Univ, Inst Natl Sante & Rech Med INSERM, Unite Rech les Malad Cardiovasc, Metabolisme & Nutr,ICAN, F-75013 Paris, France.
C3 Ministry of Education & Science of Ukraine; Odesa National University of
   Technology; Ministry of Education & Science of Ukraine; Odesa I. I.
   Mechnikov National University; Institut National de la Sante et de la
   Recherche Medicale (Inserm); Sorbonne Universite
RP Kontush, A (corresponding author), Sorbonne Univ, Inst Natl Sante & Rech Med INSERM, Unite Rech les Malad Cardiovasc, Metabolisme & Nutr,ICAN, F-75013 Paris, France.
EM skontush@odessaglobe.com; lagov.vika@gmail.com; bekshaev@onu.edu.ua;
   kontush@odessaglobe.com; wilfried.le_goff@sorbonne-universite.fr;
   anatol.kontush@sorbonne-universite.fr
RI Kontush, Anatol/J-2198-2016; Le Goff, Wilfried/N-6326-2017; Bekshaev,
   Aleksandr/S-8746-2018
OI Le Goff, Wilfried/0000-0002-7611-9644; Kontush,
   Anatol/0000-0002-9008-7335; Bekshaev, Aleksandr/0000-0003-4153-559X
FU National Institute for Health and Medical Research (INSERM; Paris,
   France); Sorbonne University (Paris, France)
FX These studies were supported by National Institute for Health and
   Medical Research (INSERM; Paris, France) and Sorbonne University (Paris,
   France).
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NR 55
TC 4
Z9 4
U1 1
U2 5
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2218-1989
J9 METABOLITES
JI Metabolites
PD JUL
PY 2022
VL 12
IS 7
AR 623
DI 10.3390/metabo12070623
PG 24
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 3H2VS
UT WOS:000831898400001
PM 35888747
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Birtwistle, L
   Chen, XM
   Pollock, C
AF Birtwistle, Lucy
   Chen, Xin-Ming
   Pollock, Carol
TI Mesenchymal Stem Cell-Derived Extracellular Vesicles to the Rescue of
   Renal Injury
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE extracellular vesicle; exosome; mesenchymal stem cells; acute kidney
   injury; chronic kidney disease; miRNA
ID CHRONIC KIDNEY-DISEASE; ISCHEMIA-REPERFUSION INJURY; HUMAN
   UMBILICAL-CORD; PERITUBULAR CAPILLARY RAREFACTION; STROMAL CELLS;
   DIABETIC-NEPHROPATHY; TUBULOINTERSTITIAL FIBROSIS; METABOLIC SYNDROME;
   IN-VIVO; MICROVESICLES PROTECT
AB Acute kidney injury (AKI) and chronic kidney disease (CKD) are rising in global prevalence and cause significant morbidity for patients. Current treatments are limited to slowing instead of stabilising or reversing disease progression. In this review, we describe mesenchymal stem cells (MSCs) and their constituents, extracellular vesicles (EVs) as being a novel therapeutic for CKD. MSC-derived EVs (MSC-EVs) are membrane-enclosed particles, including exosomes, which carry genetic information that mimics the phenotype of their cell of origin. MSC-EVs deliver their cargo of mRNA, miRNA, cytokines, and growth factors to target cells as a form of paracrine communication. This genetically reprograms pathophysiological pathways, which are upregulated in renal failure. Since the method of exosome preparation significantly affects the quality and function of MSC-exosomes, this review compares the methodologies for isolating exosomes from MSCs and their role in tissue regeneration. More specifically, it summarises the therapeutic efficacy of MSC-EVs in 60 preclinical animal models of AKI and CKD and the cargo of biomolecules they deliver. MSC-EVs promote tubular proliferation and angiogenesis, and inhibit apoptosis, oxidative stress, inflammation, the epithelial-to-mesenchymal transition, and fibrosis, to alleviate AKI and CKD. By reprogramming these pathophysiological pathways, MSC-EVs can slow or even reverse the progression of AKI to CKD, and therefore offer potential to transform clinical practice.
C1 [Birtwistle, Lucy] Univ Sydney, Fac Med & Hlth, Sydney Med Sch, Camperdown, NSW 2050, Australia.
   [Chen, Xin-Ming; Pollock, Carol] Univ Sydney, Royal North Shore Hosp, Sydney Med Sch, Kolling Inst, St Leonards, NSW 2065, Australia.
C3 University of Sydney; University of Sydney; Kolling Institute of Medical
   Research; Royal North Shore Hospital
RP Pollock, C (corresponding author), Univ Sydney, Royal North Shore Hosp, Sydney Med Sch, Kolling Inst, St Leonards, NSW 2065, Australia.
EM lbir3487@uni.sydney.edu.au; xin-ming.chen@sydney.edu.au;
   carol.pollock@sydney.edu.au
RI Pollock, Carol/H-1117-2015; Chen, Xin-Ming/D-2923-2015
OI Chen, Xin-Ming/0000-0003-3212-7172; Birtwistle, Lucy/0000-0001-6215-1072
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NR 189
TC 59
Z9 63
U1 2
U2 39
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD JUN
PY 2021
VL 22
IS 12
AR 6596
DI 10.3390/ijms22126596
PG 27
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA SZ7LQ
UT WOS:000666742300001
PM 34202940
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Bottalico, LN
   Weljie, AM
AF Bottalico, Lisa N.
   Weljie, Aalim M.
TI Cross-species physiological interactions of endocrine disrupting
   chemicals with the circadian clock
SO GENERAL AND COMPARATIVE ENDOCRINOLOGY
LA English
DT Review
DE Endocrine disruption; Circadian clock; Nuclear receptor signaling;
   Reproductive physiology; Behavioral physiology; Metabolic disruption
ID ARYL-HYDROCARBON RECEPTOR; BISPHENOL-A EXPOSURE; ROTATING SHIFT-WORK;
   MESSENGER-RNA EXPRESSION; ZEBRAFISH DANIO-RERIO; DIET-INDUCED OBESITY;
   BREAST-CANCER RISK; BETA-CELL FAILURE; GENE-EXPRESSION; METABOLIC
   SYNDROME
AB Endocrine disrupting chemicals (EDCs) are endocrine-active chemical pollutants that disrupt reproductive, neuroendocrine, cardiovascular and metabolic health across species. The circadian clock is a transcriptional oscillator responsible for entraining 24-hour rhythms of physiology, behavior and metabolism. Extensive bidirectional cross talk exists between circadian and endocrine systems and circadian rhythmicity is present at all levels of endocrine control, from synthesis and release of hormones, to sensitivity of target tissues to hormone action. In mammals, a range of hormones directly alter clock gene expression and circadian physiology via nuclear receptor (NR) binding and subsequent genomic action, modulating physiological processes such as nutrient and energy metabolism, stress response, reproductive physiology and circadian behavioral rhythms. The potential for EDCs to perturb circadian clocks or circadian-driven physiology is not well characterized. For this reason, we explore evidence for parallel endocrine and circadian disruption following EDC exposure across species. In the reviewed studies, EDCs dysregulated core clock and circadian rhythm network gene expression in brain and peripheral organs, and altered circadian reproductive, behavioral and metabolic rhythms. Circadian impacts occurred in parallel to endocrine and metabolic alterations such as impaired fertility and dysregulated metabolic and energetic homeostasis. Further research is warranted to understand the nature of interaction between circadian and endocrine systems in mediating physiological effects of EDC exposure at environmental levels.
C1 [Bottalico, Lisa N.; Weljie, Aalim M.] Univ Penn, Ctr Excellence Environm Toxicol, Perelman Sch Med, Inst Translat Med & Therapeut,Dept Syst Pharmacol, Philadelphia, PA 19104 USA.
C3 University of Pennsylvania
RP Bottalico, LN (corresponding author), Univ Penn, Perelman Sch Med, 10-196 Smilow Ctr Translat Res,3400 Civ Ctr Blvd, Philadelphia, PA 19104 USA.
EM bottlisa@pennmedicine.upenn.edu; aalim@pennmedicine.upenn.edu
RI Weljie, Aalim/B-6203-2012
OI Bottalico, Lisa/0000-0003-0884-9773
FU National Institute of Environmental Health Sciences of the National
   Institutes of Health [P30 ES013508]; National Institute of General
   Medical Sciences of the National Institutes of Health [K12 GM081259];
   National Institute of Diabetes and Digestive and Kidney Diseases of the
   National Institutes of Health [R01 DK115932]; National Institute of
   Environmental Health Sciences [T32ES019851] Funding Source: NIH RePORTER
FX We would like to acknowledge Dr. Trevor Penning, Ph.D. and Dr. Rebecca
   Simmons, M.D. for thoughtful insight on the scope of the review and
   mechanisms connecting circadian and endocrine systems. Icons present in
   the graphical abstract and Figure 3 were designed by Freepik (uterus),
   Prettycons (liver) and Eucalyp (mouse running wheel) from
   www.flaticon.com.This work was supported by the National Institute of
   Environmental Health Sciences [grant number P30 ES013508], the National
   Institute of General Medical Sciences [grant number K12 GM081259] and
   the National Institute of Diabetes and Digestive and Kidney Diseases
   [grant number R01 DK115932] of the National Institutes of Health.
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NR 271
TC 15
Z9 16
U1 0
U2 39
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0016-6480
EI 1095-6840
J9 GEN COMP ENDOCR
JI Gen. Comp. Endocrinol.
PD JAN 15
PY 2021
VL 301
AR 113650
DI 10.1016/j.ygcen.2020.113650
PG 19
WC Endocrinology & Metabolism; Zoology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Zoology
GA PP3IZ
UT WOS:000605761500005
PM 33166531
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Liu, XM
   Wang, J
   Gao, LL
   Jiao, YS
   Liu, CX
AF Liu, Xiaomei
   Wang, Jun
   Gao, Linlin
   Jiao, Yisheng
   Liu, Caixia
TI Maternal Protein Restriction Induces Alterations in Hepatic Unfolded
   Protein Response-Related Molecules in Adult Rat Offspring
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Article
DE intrauterine growth restriction; unfolded protein response; hepatic;
   glucogenesis; rat models
ID ENDOPLASMIC-RETICULUM STRESS; FATTY LIVER-DISEASE; INTRAUTERINE GROWTH
   RESTRICTION; CATCH-UP GROWTH; TRANSCRIPTION FACTOR; FETAL-GROWTH;
   OBESITY; ER; GLUCONEOGENESIS; CHOLESTEROL
AB Intrauterine growth restriction (IUGR) leads to the development of metabolic syndrome in adulthood. To explore the potential mechanisms of metabolic imprinting, we investigated the effect of malnutrition in utero on hepatic unfolded protein response (UPR)-related genes in IUGR offspring. An IUGR rat model was developed by feeding a low-protein diet to pregnant rats. The expression levels and activity of hepatic UPR genes were analysed by quantitative PCR (qPCR) arrays and western blotting. The hepatic UPR molecules heat-shock 70-kDa protein 41 (Hspa41), mitogen-activated protein kinase 10 (Mapk10), and endoplasmic reticulum to nucleus signalling 2 (Ern2) were markedly downregulated in IUGR foetuses, but the expression of Mapk10 and Ern2 returned to normal levels at 3 weeks postnatal. In contrast, cAMP responsive element binding protein 3-like 3 (Creb313) was upregulated in hepatic tissues at embryo 20(E20), then restored to normal in adulthood (12 weeks). The protein levels of activating transcription factor 2 (Atf2) and Atf6, two key factors of the UPR pathway, were upregulated in the livers of IUGR foetuses, and the latter remained upregulated until 12 weeks. Combined with our previous findings showing an increase in hepatic gluconeogenesis enzymes in IUGR offspring, we speculated that aberrant intrauterine milieu impaired UPR signalling in hepatic tissues; these alterations early in life might contribute to the predisposition of IUGR foetuses to adult metabolic disorders.
C1 [Liu, Xiaomei; Wang, Jun] China Med Univ, Shengjing Hosp, Key Lab Maternal Fetal Med Liaoning Prov, Shenyang, Liaoning, Peoples R China.
   [Wang, Jun] China Med Univ, Benxi Cent Hosp, Dept Obstet & Gynecol, Benxi, Peoples R China.
   [Gao, Linlin] China Med Univ, Shengjing Hosp, Med Res Ctr, Shenyang, Liaoning, Peoples R China.
   [Jiao, Yisheng; Liu, Caixia] China Med Univ, Shengjing Hosp, Dept Obstet & Gynaecol, Shenyang, Liaoning, Peoples R China.
C3 China Medical University; China Medical University; China Medical
   University; China Medical University
RP Liu, XM (corresponding author), China Med Univ, Shengjing Hosp, Key Lab Maternal Fetal Med Liaoning Prov, Shenyang, Liaoning, Peoples R China.
EM liuxm1@sj-hospital.org
RI Gao, Lin/JNF-0375-2023; Liu, Caixia/AAN-1192-2020
OI jiao, yisheng/0000-0001-6198-7492
FU National Natural Science Foundation of China [81571449]; Outstanding
   Scientific Fund of Shengjing Hospital [201707]
FX This work was supported by a grant from the National Natural Science
   Foundation of China (grant number. 81571449) and Outstanding Scientific
   Fund of Shengjing Hospital (grant number. 201707). We thank Editage
   Company for language editing.
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NR 42
TC 8
Z9 8
U1 0
U2 5
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD NOV 20
PY 2018
VL 9
AR 676
DI 10.3389/fendo.2018.00676
PG 14
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA HB0KC
UT WOS:000450701400001
PM 30524373
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Myllymäki, V
   Saxlin, T
   Knuuttila, M
   Rajala, U
   Keinänen-Kiukaanniemi, S
   Anttila, S
   Ylöstalo, P
AF Myllymaki, Ville
   Saxlin, Tuomas
   Knuuttila, Matti
   Rajala, Ulla
   Keinanen-Kiukaanniemi, Sirkka
   Anttila, Sirpa
   Ylostalo, Pekka
TI Association between periodontal condition and the development of type 2
   diabetes mellitus-Results from a 15-year follow-up study
SO JOURNAL OF CLINICAL PERIODONTOLOGY
LA English
DT Article
DE cohort study; oral health, periodontal condition; periodontitis; type 2
   diabetes
ID DECREASES INSULIN SENSITIVITY; OXIDATIVE STRESS; METABOLIC SYNDROME;
   TOOTH LOSS; DISEASE; RESISTANCE; GLUCOSE; METAANALYSIS; UPDATE; HEALTH
AB Aim To study whether periodontal condition is associated with the development of type 2 diabetes mellitus (T2DM). Materials and Methods Results A population-based follow-up study was conducted among persons born in 1935 and living in the city of Oulu, Finland (n = 395). The baseline examinations were done during 1990-1992, and the follow-up examinations were done during 2007-2008. The data were gathered by questionnaires, laboratory tests and clinical measurements. Poisson regression models were used in the data analyses. The adjusted rate ratios (RR) with 95% confidence intervals (95% CI) for the incident T2DM among subjects with 4-5 mm deep periodontal pockets (n = 98), among subjects with 6 mm deep or deeper periodontal pockets (n = 91), and among edentulous subjects (n = 118) were 1.32 (95% CI: 0.69-2.53), 1.56 (95% CI: 0.84-2.92) and 1.00 (95% CI: 0.53-1.89), respectively, compared to dentate subjects without deepened (4 mm deep or deeper) periodontal pockets (n = 88). The adjusted RR per site (the number of sites with deepened periodontal pockets as a continuous variable) was 1.02 (95% CI: 1.00-1.04). Conclusions Poor periodontal condition may be a predictor of the development of T2DM. However, the causality between periodontal condition and the development of T2DM remains uncertain.
C1 [Myllymaki, Ville; Saxlin, Tuomas] Univ Eastern Finland, Inst Dent, Kuopio, Finland.
   [Saxlin, Tuomas] Kuopio Univ Hosp, Dept Oral & Maxillofacial Dis, Kuopio, Finland.
   [Saxlin, Tuomas; Ylostalo, Pekka] Univ Oulu, Res Unit Oral Hlth Sci, Oulu, Finland.
   [Knuuttila, Matti; Ylostalo, Pekka] Oulu Univ Hosp, Med Res Ctr Oulu, Oulu, Finland.
   [Knuuttila, Matti; Ylostalo, Pekka] Univ Oulu, Oulu, Finland.
   [Knuuttila, Matti; Ylostalo, Pekka] Oulu Univ Hosp, Dept Oral & Maxillofacial Surg, Oulu, Finland.
   [Rajala, Ulla; Keinanen-Kiukaanniemi, Sirkka] Univ Oulu, Ctr Life Course Hlth Res, Oulu, Finland.
   [Keinanen-Kiukaanniemi, Sirkka] Oulu Univ Hosp, Unit Primary Hlth Care, Oulu, Finland.
   [Anttila, Sirpa] Teaching Hlth Ctr, Oulu, Finland.
C3 University of Eastern Finland; University of Eastern Finland; University
   of Eastern Finland Hospital; Kuopio University Hospital; University of
   Oulu; University of Oulu; University of Oulu; University of Oulu;
   University of Oulu; University of Oulu
RP Myllymäki, V (corresponding author), Univ Eastern Finland, Inst Dent, Kuopio, Finland.
EM ville.myllymaki@fimnet.fi
RI Saxlin, Tuomas/GYV-2019-2022; Ylöstalo, Pekka/AAH-2668-2021
OI Myllymaki, Ville/0000-0001-5577-1599
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NR 38
TC 21
Z9 24
U1 0
U2 10
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0303-6979
EI 1600-051X
J9 J CLIN PERIODONTOL
JI J. Clin. Periodontol.
PD NOV
PY 2018
VL 45
IS 11
BP 1276
EP 1286
DI 10.1111/jcpe.13005
PG 11
WC Dentistry, Oral Surgery & Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dentistry, Oral Surgery & Medicine
GA GZ7HR
UT WOS:000449649600001
PM 30133880
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Mirmiran, P
   Yousefi, R
   Mottaghi, A
   Azizi, F
AF Mirmiran, Parvin
   Yousefi, Reyhaneh
   Mottaghi, Azadeh
   Azizi, Fereidoun
TI Advanced glycation end products and risk of hypertension in Iranian
   adults: Tehran lipid and glucose study
SO JOURNAL OF RESEARCH IN MEDICAL SCIENCES
LA English
DT Article
DE Advanced glycation end products; hypertension; risk; Tehran lipid and
   glucose study
ID DIETARY CONSUMPTION; METABOLIC SYNDROME; OXIDATIVE STRESS;
   QUESTIONNAIRE; ENDPRODUCTS; POPULATION; DISEASE; HEALTH; INFLAMMATION;
   MANAGEMENT
AB Background:Elevated blood pressure is still one of the major risk factors for diseases and disabilities and also a public health challenge worldwide. In the present longitudinal study, we aimed to evaluate the association between risk of hypertension and dietary advanced glycation end products (AGEs) as a recently discussed potential risk factor.Materials and Methods:Dietary assessment of 1775 participants in the third phase of Tehran lipid and glucose study to obtain dietary intake of AGEs was performed using a validated semi-quantitative food frequency questionnaire, and they were followed up for a mean duration of approximately 6 years. To determine the incidence of hypertension across quartiles of AGEs intake, logistic regression models with adjustment for potential confounding variables were used. All statistical analyses were conducted using SPSS, and P < 0.05 was considered statistically significant.Results:Higher hypertension occurrence risk was generally attributed to higher AGEs intake quartiles after adjusting for age in men (odds ratio [OR] = 1.48, 95% confidence interval [CI] = 1.11-1.52, P = 0.038) and additional adjustment for smoking, drugs, and physical activity in women (OR = 1.38%-95% CI = 1.09-1.42, P = 0.042). Moreover, across the increasing trend of dietary AGEs intake, the percentage of fat intake increased and that of carbohydrate significantly decreased (P < 0.0001).Conclusion:In conclusion, it is highly recommended to limit dietary AGEs consumption to prevent and manage hypertension and its complications.
C1 [Mirmiran, Parvin] Shahid Beheshti Univ Med Sci, Nutr & Endocrine Res Ctr, Res Inst Endocrine Sci, Tehran, Iran.
   [Yousefi, Reyhaneh] Shahid Beheshti Univ Med Sci, Dept Clin Nutr & Dietet, Fac Nutr Sci & Food Technol, Tehran, Iran.
   [Mottaghi, Azadeh] Iran Univ Med Sci, Res Ctr Prevent Cardiovasc Dis, Inst Endocrinol & Metab, Tehran, Iran.
   [Azizi, Fereidoun] Shahid Beheshti Univ Med Sci, Endocrine Res Ctr, Res Inst Endocrine Sci, Tehran, Iran.
C3 Shahid Beheshti University Medical Sciences; Shahid Beheshti University
   Medical Sciences; Iran University of Medical Sciences; Shahid Beheshti
   University Medical Sciences
RP Mottaghi, A (corresponding author), Iran Univ Med Sci, Res Ctr Prevent Cardiovasc Dis, Inst Endocrinol & Metab, Tehran, Iran.
EM mottaghi.azadeh@gmail.com
RI Mirmiran, Parvin/V-1433-2019; Yousefi, Reyhaneh/AFF-9809-2022; Mottaghi,
   Azadeh/P-3177-2018; Azizi, Fereidoun/ABD-4136-2021
OI Mottaghi, Azadeh/0000-0002-1325-8946; Azizi,
   Fereidoun/0000-0002-6470-2517; Mirmiran, Parvin/0000-0003-2391-4924
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NR 36
TC 7
Z9 7
U1 0
U2 8
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, 400059, INDIA
SN 1735-1995
EI 1735-7136
J9 J RES MED SCI
JI J. Res. Med. Sci.
PD MAY
PY 2018
VL 23
AR 43
DI 10.4103/jrms.JRMS_982_17
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA GT4VV
UT WOS:000444504600005
PM 29937905
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Xia, N
   Li, HG
AF Xia, Ning
   Li, Huige
TI The role of perivascular adipose tissue in obesity-induced vascular
   dysfunction
SO BRITISH JOURNAL OF PHARMACOLOGY
LA English
DT Review
ID ENDOTHELIAL NITRIC-OXIDE; RENIN-ANGIOTENSIN SYSTEM; SAPHENOUS-VEIN
   GRAFT; SELECTIVE LEPTIN RESISTANCE; NECROSIS-FACTOR-ALPHA;
   SMOOTH-MUSCLE-CELL; HYDROGEN-SULFIDE; CONCISE GUIDE; PLASMA ADIPONECTIN;
   METABOLIC SYNDROME
AB Under physiological conditions, perivascular adipose tissue (PVAT) attenuates agonist-induced vasoconstriction by releasing vasoactive molecules including hydrogen peroxide, angiotensin 1-7, adiponectin, methyl palmitate, hydrogen sulfide, NO and leptin. This anticontractile effect of PVAT is lost under conditions of obesity. The central mechanism underlying this PVAT dysfunction in obesity is likely to be an 'obesity triad' (consisting of PVAT hypoxia, inflammation and oxidative stress) that leads to the impairment of PVAT-derived vasoregulators. The production of hydrogen sulfide, NO and adiponectin by PVAT is reduced in obesity, whereas the vasodilator response to leptin is impaired (vascular leptin resistance). Strikingly, the vasodilator response to acetylcholine is reduced only in PVAT-containing, but not in PVAT-free thoracic aorta isolated from diet-induced obese mice, indicating a unique role for PVAT in obesity-induced vascular dysfunction. Furthermore, PVAT dysfunction has also been observed in small arteries isolated from the gluteal/visceral fat biopsy samples of obese individuals. Therefore, PVAT may represent a new therapeutic target for vascular complications in obesity. A number of approaches are currently being tested under experimental conditions. Potential therapeutic strategies improving PVAT function include body weight reduction, enhancing PVAT hydrogen sulfide release (e.g. rosiglitazone, atorvastatin and cannabinoid CB1 receptor agonists) and NO production (e.g. arginase inhibitors), inhibition of the renin-angiotensin-aldosterone system, inhibition of inflammation with melatonin or cytokine antagonists, activators of AMP-activated kinase (e.g. metformin, resveratrol and diosgenin) and adiponectin releasers or expression enhancers.
C1 [Xia, Ning; Li, Huige] Johannes Gutenberg Univ Med Ctr, Dept Pharmacol, Obere Zahlbacher Str 67, D-55131 Mainz, Germany.
   [Li, Huige] Johannes Gutenberg Univ Mainz, CTVB, Mainz, Germany.
   [Li, Huige] German Ctr Cardiovasc Res DZHK, Partner Site Rhine Main, Mainz, Germany.
C3 Johannes Gutenberg University of Mainz; Johannes Gutenberg University of
   Mainz; German Centre for Cardiovascular Research
RP Li, HG (corresponding author), Johannes Gutenberg Univ Med Ctr, Dept Pharmacol, Obere Zahlbacher Str 67, D-55131 Mainz, Germany.
EM huigeli@uni-mainz.de
RI Li, Huige/M-2662-2013; Xia, Dr., Ning/P-3535-2015
OI Li, Huige/0000-0003-3458-7391; Xia, Dr., Ning/0000-0002-5553-1752
FU university intramural grant Stufe I of Johannes Gutenberg University
   Medical Center, Mainz, Germany
FX This study was supported by the university intramural grant Stufe I of
   Johannes Gutenberg University Medical Center, Mainz, Germany.
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NR 166
TC 147
Z9 158
U1 0
U2 25
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0007-1188
EI 1476-5381
J9 BRIT J PHARMACOL
JI Br. J. Pharmacol.
PD OCT
PY 2017
VL 174
IS 20
SI SI
BP 3425
EP 3442
DI 10.1111/bph.13650
PG 18
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA FH8WN
UT WOS:000411485800005
PM 27761903
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Pulopulos, MM
   Hidalgo, V
   Puig-Perez, S
   Salvador, A
AF Pulopulos, Matias M.
   Hidalgo, Vanesa
   Puig-Perez, Sara
   Salvador, Alicia
TI Cortisol awakening response and cognitive performance in hypertensive
   and normotensive older people
SO HORMONES AND BEHAVIOR
LA English
DT Article
DE Cortisol awakening response; Hypothalamic-pituitary-adrenal axis;
   Cognitive performance; Older people; Hypertension; Antihypertensive
ID BRAIN ANGIOTENSIN-II; EXECUTIVE FUNCTION; INSTRUMENTAL ACTIVITIES;
   MEMORY PERFORMANCE; METABOLIC SYNDROME; SALIVARY CORTISOL; SLEEP
   DURATION; HAIR CORTISOL; STRESS; ASSOCIATIONS
AB Healthy older people with a cortisol awakening response (CAR) of decreased magnitude show worse frontal cortex-related cognitive performance. Systemic hypertension has been related to a CAR of decreased magnitude. Additionally, worse executive function and processing speed have been observed in older people with systemic hypertension. This is the first study to examine the relationship between the CAR (measured with six saliva samples at home on two consecutive weekdays) and cognitive performance, in both hypertensive (n = 26) and normotensive (n = 28) older people (from 56 to 78 years old). Hypertensive participants showed lower morning cortisol secretion, and they also woke up earlier. No differences in CAR were observed. A CAR of decreased magnitude was related to worse executive function in both hypertensive and normotensive participants, but to slower processing speed only in normotensive participants. Being treated with antihypertensive for a longer period of time was related to a CAR of increased magnitude and better performance on executive function. Our findings suggest that earlier awakening time in hypertensive older people might underlie the lower overall morning cortisol secretion observed in previous studies. Additionally, this study confirms that a dysregulation of the CAR is related to worse executive function, and it extends this association to hypertensive older people. Finally, it is worth noting that hypertension may moderate the relationship between CAR and processing speed. (C) 2016 Elsevier Inc. All rights reserved.
C1 [Pulopulos, Matias M.; Hidalgo, Vanesa; Puig-Perez, Sara; Salvador, Alicia] Univ Valencia, Dept Psychobiol, Lab Social Cognit Neurosci, Blasco Ibanez 21, Valencia 46010, Spain.
   [Pulopulos, Matias M.; Hidalgo, Vanesa; Puig-Perez, Sara; Salvador, Alicia] Univ Valencia, IDOCAL, Blasco Ibanez 21, Valencia 46010, Spain.
C3 University of Valencia; University of Valencia
RP Pulopulos, MM (corresponding author), Univ Valencia, Dept Psychobiol, Lab Social Cognit Neurosci, Blasco Ibanez 21, Valencia 46010, Spain.; Pulopulos, MM (corresponding author), Univ Valencia, IDOCAL, Blasco Ibanez 21, Valencia 46010, Spain.
EM matias.pulopulos@uv.es
RI Salvador, Alicia/B-6045-2011; Hidalgo, Vanesa/AAU-7736-2021; Puig,
   Sara/KPY-7398-2024; Pulopulos, Matías/M-1573-2014
OI Hidalgo, Vanesa/0000-0003-3920-1099; Salvador,
   Alicia/0000-0002-8686-8083; Puig Perez, Sara/0000-0003-0635-905X;
   Pulopulos, Matias M/0000-0002-7048-3795
FU Spanish Education and Science Ministry [PSI2010/21343, PSI2013/46889,
   FPU AP2010-1830, FPI/BES-2008-004224, FPU12/04597]; Generalitat
   Valenciana [ACOMP/2013/0200, PROMETEOII2015-20, ISIC/2013/01]
FX This research was supported by the Spanish Education and Science
   Ministry (PSI2010/21343, PSI2013/46889, FPU AP2010-1830,
   FPI/BES-2008-004224 and FPU12/04597) and Generalitat Valenciana
   (ACOMP/2013/0200, PROMETEOII2015-20, ISIC/2013/01). The authors state
   that there are no conflicts of interest associated with the research.
   Grants and funding sources had no further role in the study design, in
   the collection, analysis and interpretation of the data, in the writing
   of the report, or in the decision to submit the paper for publication.
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NR 56
TC 10
Z9 10
U1 0
U2 7
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0018-506X
EI 1095-6867
J9 HORM BEHAV
JI Horm. Behav.
PD JUL
PY 2016
VL 83
BP 75
EP 82
DI 10.1016/j.yhbeh.2016.05.014
PG 8
WC Behavioral Sciences; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Behavioral Sciences; Endocrinology & Metabolism
GA DQ1SU
UT WOS:000378981500009
PM 27208824
DA 2025-06-11
ER

PT J
AU Boone-Heinonen, J
   Messer, LC
   Fortman, SP
   Wallack, L
   Thornburg, KL
AF Boone-Heinonen, Janne
   Messer, Lynne C.
   Fortman, Stephen P.
   Wallack, Lawrence
   Thornburg, Kent L.
TI From fatalism to mitigation: A conceptual framework for mitigating fetal
   programming of chronic disease by maternal obesity
SO PREVENTIVE MEDICINE
LA English
DT Review
DE Prenatal exposure delayed effects; Obesity; Physical activity;
   Nutrition; Prevention; Second hit
ID LOW-BIRTH-WEIGHT; HIGH-FAT DIET; HYPOTHALAMIC GENE-EXPRESSION; POSTNATAL
   OBESOGENIC DIET; EARLY-LIFE EXPOSURE; JUNK FOOD DIET; PHYSICAL-ACTIVITY;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; PRENATAL STRESS
AB Prenatal development is recognized as a critical period in the etiology of obesity and cardiometabolic disease. Potential strategies to reduce maternal obesity-induced risk later in life have been largely overlooked. In this paper, we first propose a conceptual framework for the role of public health and preventive medicine inmitigating the effects of fetal programming. Second, we review a small but growing body of research (through August 2015) that examines interactive effects of maternal obesity and two public health foci - diet and physical activity - in the offspring. Results of the review support the hypothesis that diet and physical activity after early life can attenuate disease susceptibility induced by maternal obesity, but human evidence is scant. Based on the review, we identify major gaps relevant for prevention research, such as characterizing the type and dose response of dietary and physical activity exposures that modify the adverse effects of maternal obesity in the offspring. Third, we discuss potential implications of interactions between maternal obesity and postnatal dietary and physical activity exposures for interventions to mitigate maternal obesity-induced risk among children. Our conceptual framework, evidence review, and future research directions offer a platform to develop, test, and implement fetal programming mitigation strategies for the current and future generations of children. (C) 2015 Elsevier Inc. All rights reserved.
C1 [Boone-Heinonen, Janne] Oregon Hlth & Sci Univ, Sch Publ Hlth, Portland, OR 97201 USA.
   [Messer, Lynne C.; Wallack, Lawrence] Portland State Univ, Sch Community Hlth, Coll Urban & Publ Affairs, Portland, OR 97207 USA.
   [Fortman, Stephen P.] Kaiser Permanente Ctr Hlth Res, Portland, OR USA.
   [Thornburg, Kent L.] Oregon Hlth & Sci Univ, Bob & Charlee Moore Inst Nutr & Wellness, Portland, OR 97201 USA.
C3 Oregon Health & Science University; Portland State University; Kaiser
   Permanente; Oregon Health & Science University
RP Boone-Heinonen, J (corresponding author), 3181 SW Sam Jackson Pk Rd,Mail Code CB669, Portland, OR 97239 USA.
EM boonej@ohsu.edu
FU Office of Research in Women's Health; National Institute of Child Health
   and Human Development, Oregon BIRCWH Award [K12HD043488-01]; OHSU
   Edwards Endowment;  [2PO1HD34430]
FX The project described was funded by the Office of Research in Women's
   Health and the National Institute of Child Health and Human Development,
   Oregon BIRCWH Award Number K12HD043488-01 (JBH). KLT is supported by
   2PO1HD34430 and the OHSU Edwards Endowment. We thank Jenny Marx for her
   information design expertise and creation of Fig. 1, and Laura Zeigen
   for her library science expertise.
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NR 136
TC 9
Z9 11
U1 0
U2 7
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0091-7435
EI 1096-0260
J9 PREV MED
JI Prev. Med.
PD DEC
PY 2015
VL 81
BP 451
EP 459
DI 10.1016/j.ypmed.2015.10.012
PG 9
WC Public, Environmental & Occupational Health; Medicine, General &
   Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health; General & Internal Medicine
GA DB3OP
UT WOS:000368421300071
PM 26522092
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Silva, LR
   Cavaglieri, C
   Lopes, WA
   Pizzi, J
   Coelho-e-Silva, MJC
   Leite, N
AF Silva, Larissa R.
   Cavaglieri, Claudia
   Lopes, Wendell A.
   Pizzi, Juliana
   Coelho-e-Silva, Manuel J. C.
   Leite, Neiva
TI Endothelial wall thickness, cardiorespiratory fitness and inflammatory
   markers in obese and non-obese adolescents
SO BRAZILIAN JOURNAL OF PHYSICAL THERAPY
LA English
DT Article
DE obesity; inflammation; atherosclerosis; adolescents; fitness; physical
   therapy
ID INTIMA-MEDIA THICKNESS; VISCERAL FAT ACCUMULATION; INSULIN-RESISTANCE;
   CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; OXIDATIVE STRESS; BODY-MASS;
   CHILDREN; ATHEROSCLEROSIS; ADIPONECTIN
AB Background: Increased carotid intima-media thickness (c-IMT) is considered a marker of early-onset atherosclerosis and it has been found in obese children and adolescents, but the risk factors associated with this population remain to be elucidated. Objective: To compare and verify the relationship between c-IMT, metabolic profile, inflammatory markers, and cardiorespiratory fitness in obese and non-obese children and adolescents. Method: Thirty-five obese subjects (19 boys) and 18 non-obese subjects (9 boys), aged 10-16 years, were included. Anthropometry, body composition, blood pressure, maximal oxygen consumption (VO(2)max), and basal metabolic rate were evaluated. Serum glucose, insulin, homeostasis model assessment of insulin resistance (HOMA-IR), blood lipids, C-reactive protein (CRP), and adiponectin were assessed. c-IMT was measured by ultrasound. Results: The results showed that c-IMT, triglycerides, insulin, HOMA-IR, and CRP values were significantly higher in the obese group than in the non-obese group, and high-density lipoprotein cholesterol (HDL-c), adiponectin, and VO(2)max values were significantly lower in the obese group than in the non-obese group. The c-IMT was directly correlated with body weight, waist circumference, % body fat, and HOMA-IR and inversely correlated with % free fat mass, HDL-c, and VO(2)max. Conclusions: Our findings show that c-IMT correlates not only with body composition, lipids, insulin resistance, and inflammation but also with low VO(2)max values in children and adolescents.
C1 [Silva, Larissa R.; Leite, Neiva] Univ Fed Parana UFPR, Dept Phys Educ, Curitiba, Parana, Brazil.
   [Cavaglieri, Claudia; Lopes, Wendell A.] Univ Estadual Campinas UNICAMP, Fac Phys Educ, Campinas, SP, Brazil.
   [Pizzi, Juliana] Univ Parana UNIPAR, Dept Phys Educ, Francisco Beltrao, PR, Brazil.
   [Coelho-e-Silva, Manuel J. C.] Univ Coimbra, Fac Sports Sci & Phys Educ, Res Ctr Sport & Phys Act, Coimbra, Portugal.
C3 Universidade Federal do Parana; Universidade Estadual de Campinas;
   Universidade de Coimbra
RP Silva, LR (corresponding author), Univ Fed Parana, Dept Educ Fis, Travessa Coracao Maria,92,BR 116,Km 95,Jardim Bot, BR-80215370 Curitiba, Parana, Brazil.
EM larisilva99@yahoo.com.br
RI Lopes, Wendell/F-7415-2012; Leite, Neiva/T-8239-2019; Coelho-e-Silva,
   Manuel/O-2604-2019; Cavaglieri, Claudia/C-4291-2012
OI Leite, Neiva/0000-0002-4752-6697; Coelho-e-Silva,
   Manuel/0000-0003-4512-7331; Cavaglieri, Claudia/0000-0002-7795-6575
FU Fundacao para a Cienciae Tecnologia (FCT), Portugal; Coordenacao de
   Aperfeicoamento de Pessoal de Nivel Superior (CAPES), Brazil; Conselho
   Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq), Brazil
FX The authors wish to thank Fundacao para a Cienciae Tecnologia (FCT),
   Portugal, Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior
   (CAPES), Brazil, and Conselho Nacional de Desenvolvimento Cientifico e
   Tecnologico (CNPq), Brazil, for their funding.
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NR 43
TC 16
Z9 17
U1 0
U2 11
PU ASSOCIACAO BRASILEIRA PESQUISA POS-GRADUACAO FISIOTERAPIA-ABRAPG-FT
PI SAO CARLOS SP
PA ROD WASHINGTON LUIS, KM 235, CAIXA POSTAL 676, SAO CARLOS SP,
   CEP13565-905, BRAZIL
SN 1413-3555
EI 1809-9246
J9 BRAZ J PHYS THER
JI Braz. J. Phys. Ther.
PD JAN-FEB
PY 2014
VL 18
IS 1
BP 47
EP 55
DI 10.1590/S1413-35552012005000133
PG 9
WC Orthopedics; Rehabilitation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Rehabilitation
GA AE0PK
UT WOS:000333668100006
PM 24675912
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Aoqui, C
   Cuppari, L
   Kamimura, MA
   Canziani, MEF
AF Aoqui, C.
   Cuppari, L.
   Kamimura, M. A.
   Canziani, M. E. F.
TI Increased visceral adiposity is associated with coronary artery
   calcification in male patients with chronic kidney disease
SO EUROPEAN JOURNAL OF CLINICAL NUTRITION
LA English
DT Article
DE chronic kidney disease; coronary artery calcification; visceral obesity;
   adipokines
ID HEMODIALYSIS-PATIENTS; COMPUTED-TOMOGRAPHY; ABDOMINAL OBESITY; FAT
   ACCUMULATION; RISK-FACTORS; CARDIOVASCULAR MORTALITY; WAIST
   CIRCUMFERENCE; INSULIN-RESISTANCE; METABOLIC SYNDROME; OXIDATIVE STRESS
AB BACKGROUND/OBJECTIVE: Recent epidemiological data have shown that abdominal fat accumulation is associated with increased risk of cardiovascular events in patients with chronic kidney disease (CKD). This study aimed to investigate the association between visceral adiposity and coronary artery calcification (CAC) in CKD patients.
   SUBJECTS/METHODS: Cross-sectional study with 65 nondialyzed CKD male patients (59 +/- 9 years, CKD stages 3 and 4). Abdominal fat compartments were assessed by computed tomography (CT) at L4-L5 level. Visceral to subcutaneous (V/S) fat ratio was calculated. Visceral obesity was defined as a V/S fat ratio greater than the median value of the sample study (>0.55). CAC was detected by multi-slice CT. CAC scores were calculated with the Agatston method.
   RESULTS: CAC was present (calcium score > 10 AU) in 66% of patients. In the group with visceral obesity, the CAC score was significantly higher. This group had lower adiponectin and higher leptin levels compared to patients without visceral obesity. In the whole sample, higher V/S fat ratio was associated with CAC score, independently of age, body mass index, diabetes, ionized calcium, smoking or renal function.
   CONCLUSION: Our results show an association between visceral obesity and CAC in CKD patients, suggesting a deleterious effect of visceral fat in these patients. Increased visceral adiposity might enhance cardiovascular risk in this particular population.
C1 [Aoqui, C.; Cuppari, L.; Kamimura, M. A.; Canziani, M. E. F.] Univ Fed Sao Paulo, Div Nephrol, Dept Internal Med, BR-04039000 Sao Paulo, Brazil.
C3 Universidade Federal de Sao Paulo (UNIFESP)
RP Canziani, MEF (corresponding author), Univ Fed Sao Paulo, Div Nephrol, Dept Internal Med, Pedro de Toledo Str 282, BR-04039000 Sao Paulo, Brazil.
EM dialisefor@uol.com.br
RI Cuppari, Lilian/C-3394-2012; Kamimura, Maria/D-1267-2014; Canziani,
   Maria E F/AGI-3240-2022
FU Oswaldo Ramos Foundation and Sao Paulo Foundation for Research Support
   (FAPESP) [05/02442-4]
FX This study was supported by the Oswaldo Ramos Foundation and Sao Paulo
   Foundation for Research Support (FAPESP number: 05/02442-4).
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NR 47
TC 22
Z9 22
U1 0
U2 3
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0954-3007
J9 EUR J CLIN NUTR
JI Eur. J. Clin. Nutr.
PD JUN
PY 2013
VL 67
IS 6
BP 610
EP 614
DI 10.1038/ejcn.2013.66
PG 5
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 158KA
UT WOS:000319967700008
PM 23531780
DA 2025-06-11
ER

PT J
AU Stern, JE
   Filosa, JA
AF Stern, J. E.
   Filosa, J. A.
TI Bidirectional neuro-glial signaling modalities in the hypothalamus: Role
   in neurohumoral regulation
SO AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL
LA English
DT Article
DE Paraventricular; Supraoptic; Astrocytes; Microglia; Sympathetic;
   Neuroendocrine; Oxytocin; Vasopressin; Nitric oxide; Glutamate; GABA
ID NITRIC-OXIDE SYNTHASE; RECEPTOR-MEDIATED INHIBITION; INDUCED VASOPRESSIN
   RELEASE; SYMPATHETIC-NERVE ACTIVITY; PARAVENTRICULAR NUCLEUS; SUPRAOPTIC
   NUCLEUS; CARBON-MONOXIDE; NMDA RECEPTORS; MAGNOCELLULAR NEURONS;
   RAT-BRAIN
AB Maintenance of bodily homeostasis requires concerted interactions between the neuroendocrine and the autonomic nervous systems, which generate adaptive neurohumoral outflows in response to a variety of sensory inputs. Moreover, an exacerbated neurohumoral activation is recognized to be a critical component in numerous disease conditions, including hypertension, heart failure, stress, and the metabolic syndrome. Thus, the study of neurohumoral regulation in the brain is of critical physiological and pathological relevance. Most of the work in the field over the last decades has been centered on elucidating neuronal mechanisms and pathways involved in neurohumoral control. More recently however, it has become increasingly clear that non-neuronal cell types, particularly astrocytes and microglial cells, actively participate in information processing in areas of the brain involved in neuroendocrine and autonomic control. Thus, in this work, we review recent advances in our understanding of neuro-glial interactions within the hypothalamic supraoptic and paraventricular nuclei, and their impact on neurohumoral integration in these nuclei. Major topics reviewed include anatomical and functional properties of the neuro-glial microenvironment, neuron-to-astrocyte signaling, gliotransmitters, and astrocyte regulation of signaling molecules in the extracellular space. We aimed in this review to highlight the importance of neuro-glial bidirectional interactions in information processing within major hypothalamic networks involved in neurohumoral integration. (C) 2013 Elsevier B.V. All rights reserved.
C1 [Stern, J. E.; Filosa, J. A.] Georgia Hlth Sci Univ, Dept Physiol, Augusta, GA 30912 USA.
C3 University System of Georgia; Augusta University
RP Stern, JE (corresponding author), Georgia Hlth Sci Univ, Dept Physiol, 1120 15th St, Augusta, GA 30912 USA.
EM jstern@georgiahealth.edu
RI Filosa, Jessica/ABG-4524-2020
FU National Heart, Lung, and Blood Institute [R01HL085767, R21HL113801,
   R01HL089067]
FX This work was supported by the National Heart, Lung, and Blood Institute
   grants R01HL085767 and R21HL113801 to Stern JE and a R01HL089067 to
   Filosa JA.
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NR 179
TC 25
Z9 29
U1 0
U2 17
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1566-0702
EI 1872-7484
J9 AUTON NEUROSCI-BASIC
JI Auton. Neurosci-Basic Clin.
PD APR
PY 2013
VL 175
IS 1-2
SI SI
BP 51
EP 60
DI 10.1016/j.autneu.2012.12.009
PG 10
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 150DA
UT WOS:000319369200007
PM 23375650
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Del Bo', C
   Tucci, M
   Martini, D
   Marino, M
   Bertoli, S
   Battezzati, A
   Porrini, M
   Riso, P
AF Del Bo', Cristian
   Tucci, Massimiliano
   Martini, Daniela
   Marino, Mirko
   Bertoli, Simona
   Battezzati, Alberto
   Porrini, Marisa
   Riso, Patrizia
TI Acute effect of blueberry intake on vascular function in older subjects:
   Study protocol for a randomized, controlled, crossover trial
SO PLOS ONE
LA English
DT Article
ID PERIPHERAL ARTERIAL DYSFUNCTION; DOUBLE-BLIND; ENDOTHELIAL FUNCTION;
   AUGMENTATION INDEX; REACTIVE HYPEREMIA; METABOLIC SYNDROME;
   BLOOD-PRESSURE; DNA-DAMAGE; WOMEN; RISK
AB Aging is associated with an increased risk of developing cardiovascular disease which is often accompanied by a decline in vascular health and function. Current evidence suggests that berries may have a potential role in the modulation of vascular function, but dietary interventions are still needed to confirm findings, especially in older subjects. In the context of the MIND FoodS HUB project, this study aims to investigate the effect of a single serving of blueberry (250 g of blueberry versus a control product) in a group of older subjects (>= 60y) through a randomized, controlled, cross-over dietary intervention trial. Specifically, the study evaluates the absorption kinetics of bioactives following the blueberries intake and the effects on markers related to oxidative stress, inflammation, and vascular function analyzed at different time points. By considering a drop-out rate estimate of 25%, at least 20 subjects will be recruited in the study. The study will provide evidence to support the potential beneficial effects of blueberry and its bioactive compounds on vascular function in a group of population more susceptible to vascular dysfunction and to the development of cardiovascular diseases. Moreover, the study will contribute the analysis of several metabolic and functional markers that can support the biological plausibility of the results obtained. Finally, the trial will provide data on the absorption and metabolism of blueberry bioactives which will be used to study their association with the different markers under study.
C1 [Del Bo', Cristian; Tucci, Massimiliano; Martini, Daniela; Marino, Mirko; Bertoli, Simona; Battezzati, Alberto; Porrini, Marisa; Riso, Patrizia] Univ Milan, Dept Food Environm & Nutr Sci DeFENS, Div Human Nutr, Milan, Italy.
   [Bertoli, Simona; Battezzati, Alberto] Univ Milan, Int Ctr Assessment Nutr Status ICANS, Dept Food Environm & Nutr Sci DeFENS, Milan, Italy.
C3 University of Milan; University of Milan
RP Riso, P (corresponding author), Univ Milan, Dept Food Environm & Nutr Sci DeFENS, Div Human Nutr, Milan, Italy.
EM patrizia.riso@unimi.it
RI Battezzati, Alberto/J-1717-2012; Riso, Patrizia/AAC-2072-2019; Martini,
   Daniela/S-2499-2019; Marino, Mirko/AAI-5389-2020; porrini,
   marisa/AAF-6788-2021; Bertoli, Simona/K-2805-2018; Del Bò,
   Cristian/AFT-1534-2022; martini, daniela/D-6241-2015
OI martini, daniela/0000-0001-8298-926X; MARINO, MIRKO/0000-0001-9913-4380;
   Riso, Patrizia/0000-0002-9204-7257; porrini, marisa/0000-0003-2693-3311
FU Lombardy Region (POR FESR 2014-2020_BANDO Call HUB Ricerca e
   Innovazione) [727]
FX This research is funded by the Lombardy Region (POR FESR 2014-2020_BANDO
   Call HUB Ricerca e Innovazione _D.G.R. NR 727 del 5/11/2018) within the
   project MIND FoodS Hub (Milano Innovation District Food System Hub):
   Innovative concept for the eco-intensification of agricultural
   production and for the promotion of dietary patterns for human health
   and longevity through the creation in MIND of a digital Food System Hub.
   The funder has no role in defining the study, in data collection,
   management, analysis or interpretation of the data, nor in the writing
   and submitting of manuscripts resulting from this study.
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NR 57
TC 5
Z9 5
U1 1
U2 28
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD DEC 1
PY 2022
VL 17
IS 12
AR e0275132
DI 10.1371/journal.pone.0275132
PG 16
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 8O3JO
UT WOS:000925734000020
PM 36454906
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Kaorop, W
   Maneechote, C
   Kumfu, S
   Chattipakorn, SC
   Chattipakorn, N
AF Kaorop, Wichida
   Maneechote, Chayodom
   Kumfu, Sirinart
   Chattipakorn, Siriporn C.
   Chattipakorn, Nipon
TI Mitochondrial-derived peptides as a novel intervention for obesity and
   cardiac diseases: bench evidence for potential bedside application
SO JOURNAL OF CLINICAL PATHOLOGY
LA English
DT Article
DE apoptosis; diabetes mellitus; heart; myocardial ischemia; pathology;
   molecular
ID MOTS-C; OXIDATIVE STRESS; HUMANIN; DYSFUNCTION; PGC-1-ALPHA; MECHANISMS;
   REGULATORS; GLUCOSE; AMPK
AB Currently, obesity is the most common major health problem for people worldwide. Obesity is known to be a significant risk factor for several diseases, including metabolic syndrome, insulin resistance and type 2 diabetes, eventually leading to the development of chronic systemic disorders. Previous studies showed that mitochondrial dysfunction could be one of the potential mechanisms for obesity progression. Most interventions used for combating obesity have also been reported to modulate mitochondrial function, suggesting the potential role of mitochondria in the pathology of the obese condition. Recent studies have shown that peptides produced by mitochondria, mitochondrial-derived peptides (MDPs), potentially improve metabolic function and exert benefits in obesity-associated diabetes and various heart pathologies. In this review, the roles of MDPs in the metabolic pathways and their use in the treatment of various adverse effects of obesity are comprehensively summarised based on collective evidence from in vitro, in vivo and clinical studies. The roles of MDPs as novel therapeutic interventions for cardiac dysfunction caused by various stresses or toxicities are also presented and discussed. This review aims to summarise the knowledge regarding the effects of MDPs on obesity, with a particular emphasis on their potential protective effects on the impaired cardiac function associated with obesity. The information from this review will also encourage further clinical investigations to warrant the potential application of MDP interventions in the clinical setting in the future.
C1 [Kaorop, Wichida; Maneechote, Chayodom; Kumfu, Sirinart; Chattipakorn, Siriporn C.; Chattipakorn, Nipon] Chiang Mai Univ, Fac Med, Cardiac Electrophysiol Res & Training Ctr, Chiang Mai, Thailand.
   [Kaorop, Wichida; Kumfu, Sirinart; Chattipakorn, Nipon] Chiang Mai Univ, Fac Med, Dept Physiol, Cardiac Electrophysiol Unit, Chiang Mai, Thailand.
   [Kaorop, Wichida; Maneechote, Chayodom; Kumfu, Sirinart; Chattipakorn, Siriporn C.; Chattipakorn, Nipon] Chiang Mai Univ, Ctr Excellence Cardiac Electrophysiol Res, Chiang Mai, Thailand.
   [Chattipakorn, Siriporn C.] Chiang Mai Univ, Fac Dent, Dept Oral Biol & Diagnost Sci, Chiang Mai, Thailand.
C3 Chiang Mai University; Chiang Mai University; Chiang Mai University;
   Chiang Mai University
RP Chattipakorn, N (corresponding author), Chiang Mai Univ, Fac Med, Cardiac Electrophysiol Res & Training Ctr, Chiang Mai, Thailand.
EM nchattip@gmail.com
RI Chattipakorn, Nipon/AAJ-4049-2021
OI Chattipakorn, Siriporn/0000-0003-1677-7052; Chattipakorn,
   Nipon/0000-0003-3026-718X
FU National Science and Technology Development Agency Thailand; Chiang Mai
   University Center of Excellence Award; National Research Council of
   Thailand; Fundamental Fund 2022; Chiang Mai University [FF65/044];
   National Research Council of Thailand (NRCT) [N42A650187, N42A650303];
   NRCT-Royal Golden Jubilee Program [N41A650084]
FX This work was supported by the NSTDA Research Chair grant from the
   National Science and Technology Development Agency Thailand (NC), the
   Senior Research Scholar Grant from the National Research Council of
   Thailand (SCC), the Chiang Mai University Center of Excellence Award
   (NC), the National Research Council of Thailand, Fundamental Fund 2022,
   Chiang Mai University (FF65/044) (CM), the National Research Council of
   Thailand (NRCT) (N42A650187, CM) and (N42A650303, SK) and the National
   Research Council of Thailand grants NRCT-Royal Golden Jubilee Program
   (N41A650084) (WK and NC).
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TC 0
Z9 0
U1 0
U2 6
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 0021-9746
EI 1472-4146
J9 J CLIN PATHOL
JI J. Clin. Pathol.
PD NOV
PY 2022
VL 75
IS 11
BP 724
EP 730
DI 10.1136/jcp-2022-208321
EA JUL 2022
PG 7
WC Pathology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pathology
GA 5T7XB
UT WOS:000830467800001
PM 35863886
DA 2025-06-11
ER

PT J
AU Satiya, J
   Snyder, HS
   Singh, SP
   Satapathy, SK
AF Satiya, Jinendra
   Snyder, Heather S.
   Singh, Shivaram Prasad
   Satapathy, Sanjaya K.
TI Narrative review of current and emerging pharmacological therapies for
   nonalcoholic steatohepatitis
SO TRANSLATIONAL GASTROENTEROLOGY AND HEPATOLOGY
LA English
DT Review
DE Cirrhosis; fibrosis; nonalcoholic fatty liver disease (NAFLD);
   nonalcoholic steatohepatitis (NASH); treatment
ID FATTY LIVER-DISEASE; MODERATE ALCOHOL-CONSUMPTION; ACTIVATED
   PROTEIN-KINASE; VITAMIN-E; HEPATIC STEATOSIS; WEIGHT-LOSS; BILE-ACIDS;
   DECREASED PREVALENCE; PEPTIDE-1 RECEPTOR; METABOLIC SYNDROME
AB Nonalcoholic steatohepatitis (NASH) is the most common cause of chronic liver disease today, and it has now emerged as the leading etiology of end-stage liver disease requiring liver transplantation. It is a progressive form of non-alcoholic fatty liver disease which can not only progress to cirrhosis of liver and hepatocellular carcinoma (HCC), but is associated with increased cardiovascular risks too. Despite all the advances in the understanding of the risk factors and the pathogenetic pathways involved in the pathogenesis and progression of NASH, an effective therapy for NASH has not been developed yet. Although lifestyle modifications including dietary modifications and physical activity remain the mainstay of therapy, there is an unmet need to develop a drug or a combination of drugs which can not only reduce the fatty infiltration of the liver, but also arrest the development and progression of fibrosis and advancement to cirrhosis of liver and HCC. The pharmacologic therapies which arc being developed target the various components believed to be involved in the pathogenesis of nonalcoholic fatty liver disease (NAFLD)NASH which includes insulin resistance, lipid metabolism oxidative stress, lipid peroxidation, inflammatory and cell death pathways, and fibrosis. In this review, we summarize the current state of knowledge on pharmacotherapy of NASH, and also highlight the recent developments in the field, for optimizing the management and treatment of NASH.
C1 [Satiya, Jinendra] Harvard Med Sch, Div Gastroenterol & Hepatol, Beth Israel Deaconess Med Ctr, Boston, MA 02115 USA.
   [Snyder, Heather S.] Emory Univ Hosp, Dept Pharm, 1364 Clifton Rd NE, Atlanta, GA 30322 USA.
   [Singh, Shivaram Prasad] SCB Med Coll, Dept Gastroenterol, Cuttack, India.
   [Singh, Shivaram Prasad] Kalinga Gastroenterol Fdn, Beam Diagnost Ctr, Cuttack, India.
   [Satapathy, Sanjaya K.] Northwell Hlth, Sandra Atlas Bass Ctr Liver Dis & Transplantat, Div Hepatol, Manhasset, NY USA.
C3 Harvard University; Harvard Medical School; Harvard University Medical
   Affiliates; Beth Israel Deaconess Medical Center; Emory University;
   Srirama Chandra Bhanja Medical College & Hospital; Northwell Health
RP Satapathy, SK (corresponding author), Barbara & Zucker Sch Med Hofstra Northwell Hlth, Div Hepatol, Dept Internal Med, Sandra Atlas Bass Ctr Liver Dis & Transplantat, 400 Community Dr, Manhasset, NY 11030 USA.
EM ssatapat@northwell.edu
RI Satapathy, Sanjaya/AAG-9830-2019; Singh, Shivaram/AAR-1521-2020; Satiya,
   Jinendra/M-8726-2019
OI Satapathy, Sanjaya/0000-0003-0153-2829
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NR 122
TC 7
Z9 7
U1 0
U2 2
PU AME PUBLISHING COMPANY
PI SHATIN
PA FLAT-RM C 16F, KINGS WING PLAZA 1, NO 3 KWAN ST, SHATIN, HONG KONG
   00000, PEOPLES R CHINA
EI 2415-1289
J9 TRANSL GASTROENT HEP
JI Transl. Gastroenterol. Hepatol.
PD OCT
PY 2021
VL 6
AR 60
DI 10.21037/tgh-20-247
EA SEP 2020
PG 18
WC Gastroenterology & Hepatology
WE Emerging Sources Citation Index (ESCI)
SC Gastroenterology & Hepatology
GA WW9SU
UT WOS:000675480300001
PM 34805582
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Garber, A
   Hastie, P
   Murray, JA
AF Garber, Anna
   Hastie, Peter
   Murray, Jo-Anne
TI Factors Influencing Equine Gut Microbiota: Current Knowledge
SO JOURNAL OF EQUINE VETERINARY SCIENCE
LA English
DT Review
DE Horse; Gut microbiota; Equine; NGS; Microbiome; 16S rRNA gene sequencing
ID YEAST CULTURE SUPPLEMENTATION; SACCHAROMYCES-CEREVISIAE SUPPLEMENTATION;
   APPARENT NUTRIENT DIGESTIBILITY; FECAL MICROBIOTA; HIGH-FIBER;
   INTESTINAL PERMEABILITY; GASTROINTESTINAL-TRACT; BACTERIAL COMMUNITIES;
   HINDGUT MICROBIOTA; METABOLIC SYNDROME
AB Gastrointestinal microbiota play a crucial role in nutrient digestion, maintaining animal health and welfare. Various factors may affect microbial balance often leading to disturbances that may result in debilitating conditions such as colic and laminitis. The invention of next-generation sequencing technologies and bioinformatics has provided valuable information on the effects of factors influencing equine gut microbiota. Among those factors are nutrition and management (e.g., diet, supplements, exercise), medical substances (e.g., antimicrobials, anthelmintics, anesthetics), animal-related factors (breed and age), various pathological conditions (colitis, diarrhea, colic, laminitis, equine gastric ulcer syndrome), as well as stress-related factors (transportation and weaning). The aim of this review is to assimilate current knowledge on equine microbiome studies, focusing on the effect of factors influencing equine gastrointestinal microbiota. Decrease in microbial diversity and richness leading to decrease in stability; decrease in Lachnospiraceae and Ruminococcaceae family members, which contribute to gut homeostasis; increase in Lactobacillus and Streptococcus; decrease in lactic acid utilizing bacteria; decrease in butyrate-producing bacteria that have anti-inflammatory properties may all be considered as a negative change in equine gut microbiota. Shifts in Firmicutes and Bacteroidetes have often been observed in the literature in response to certain treatments or when describing healthy and unhealthy animals; however, these shifts are inconsistent. It is time to move forward and use the knowledge now acquired to start manipulating the microbiota of horses. (C) 2020 Elsevier Inc. All rights reserved.
C1 [Garber, Anna; Hastie, Peter; Murray, Jo-Anne] Univ Glasgow, Coll Med Vet & Life Sci, Sch Vet Med, Glasgow G61 1QH, Lanark, Scotland.
C3 University of Glasgow
RP Garber, A (corresponding author), Univ Glasgow, Coll Med Vet & Life Sci, Sch Vet Med, Glasgow G61 1QH, Lanark, Scotland.
EM Anna.Garber@glasgow.ac.uk
RI Garber, Anna/AAT-9162-2020
OI Garber, Anna/0000-0001-8762-7030
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NR 161
TC 90
Z9 96
U1 4
U2 47
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0737-0806
EI 1542-7412
J9 J EQUINE VET SCI
JI J. Equine Vet. Sci.
PD MAY
PY 2020
VL 88
AR 102943
DI 10.1016/j.jevs.2020.102943
PG 12
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA LE1XW
UT WOS:000526518500009
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Navarro-Prado, S
   Schmidt-RioValle, J
   Montero-Alonso, MA
   Fernández-Aparicio, A
   González-Jiménez, E
AF Navarro-Prado, Silvia
   Schmidt-RioValle, Jacqueline
   Montero-Alonso, Miguel A.
   Fernandez-Aparicio, Angel
   Gonzalez-Jimenez, Emilio
TI Stricter Adherence to Dietary Approaches to Stop Hypertension (DASH) and
   Its Association with Lower Blood Pressure, Visceral Fat, and Waist
   Circumference in University Students
SO NUTRIENTS
LA English
DT Article
DE blood pressure; eating habits; university students; young adults;
   Dietary Approaches to Stop Hypertension (DASH)
ID METABOLIC SYNDROME; OXIDATIVE STRESS; RISK; PATTERNS; SUPPLEMENTATION;
   METAANALYSIS; CONSUMPTION; CHILDHOOD; NUTRIENTS; ADULTHOOD
AB How diet affects blood pressure (BP) in young adults has not been studied in sufficient depth. For this purpose, we analyzed adherence to the Dietary Approaches to Stop Hypertension (DASH) dietary pattern and BP in Spanish university students. The sample population of our cross-sectional study consisted of 244 subjects (18-31 years old), who were in good health. Measurements were taken of their systolic and diastolic BP. A food frequency questionnaire and 72 h food record were used to assess their dietary intake in the previous year. The resulting DASH score was based on foodstuffs that were emphasized or minimized in the DASH diet. Analysis of covariance adjusted for potential confounding factors showed that the mean values for systolic BP, visceral fat rating, and waist circumference (WC) of the subjects in the upper third of the DASH score were significantly lower than those of the subjects in the lower third (for systolic BP: mean difference -4.36 mmHg, p = 0.004; for visceral fat rating: mean difference -0.4, p = 0.024; for waist circumference: mean difference -3.2, p = 0.019). Stricter adherence to the DASH dietary pattern led to a lower BP, visceral fat rating, and WC values in these university students. Nevertheless, further prospective studies are needed to confirm these results.
C1 [Navarro-Prado, Silvia] Univ Granada, Fac Hlth Sci, Dept Nursing, Melilla 52071, Spain.
   [Schmidt-RioValle, Jacqueline; Fernandez-Aparicio, Angel; Gonzalez-Jimenez, Emilio] Univ Granada, Fac Hlth Sci, Dept Nursing, Granada 18016, Spain.
   [Montero-Alonso, Miguel A.] Univ Granada, Dept Stat, Granada 18016, Spain.
   [Montero-Alonso, Miguel A.] Univ Granada, OI Fac Med, Granada 18016, Spain.
C3 University of Granada; University of Granada; University of Granada;
   University of Granada
RP Schmidt-RioValle, J (corresponding author), Univ Granada, Fac Hlth Sci, Dept Nursing, Granada 18016, Spain.
EM silnado@ugr.es; jschmidt@ugr.es; mmontero@ugr.es; anfeapa@ugr.es;
   emigoji@ugr.es
RI Montero-Alonso, Miguel Ángel/F-3470-2016; Gonzalez-Jimenez,
   Emilio/I-6039-2017; Fernandez-Aparicio, Angel/K-8130-2017;
   Schmidt-Riovalle, Jacqueline/I-6333-2017
OI Montero-Alonso, Miguel Angel/0000-0002-1214-9035; Navarro-Prado,
   Silvia/0000-0002-9713-2864; Gonzalez-Jimenez,
   Emilio/0000-0001-5103-6028; Fernandez-Aparicio,
   Angel/0000-0002-1298-8349; Schmidt-Riovalle,
   Jacqueline/0000-0003-2775-0058
FU Faculty of Nursing of Melilla (University of Granada)
FX This study was funded by the Programme Contract (2015-2017) of the
   Faculty of Nursing of Melilla (University of Granada), specifically the
   research line "Lifestyles and health care in a multicultural
   population".
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NR 42
TC 12
Z9 14
U1 0
U2 10
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD MAR
PY 2020
VL 12
IS 3
AR 740
DI 10.3390/nu12030740
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA LL8VB
UT WOS:000531831000149
PM 32168861
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Tousian, H
   Razavi, BM
   Hosseinzadeh, H
AF Tousian, Hourieh
   Razavi, Bibi Marjan
   Hosseinzadeh, Hossein
TI Alpha-mangostin decreased cellular senescence in human umbilical vein
   endothelial cells
SO DARU-JOURNAL OF PHARMACEUTICAL SCIENCES
LA English
DT Article
DE Alpha-mangostin; High glucose; Diabetes; Senescence; SIRT1; HUVEC
ID SIRT1; XANTHONES; PATHWAYS; STRESS
AB Background The hyperglycemic condition in diabetes induces cellular senescence in vascular endothelial cells and causes cardiovascular complications. Alpha-mangostin is a xanthone found in Garcinia mangostana, and has shown protective effects in metabolic syndrome.
   Objective In this study, the anti-senescence effects of alpha-mangostin in the hyperglycemic condition are investigated.
   Methods HUVECs were incubated with high glucose for 6 days and co-treated by metformin or alpha-mangostin. After 6 days, cell viability, reactive oxygen species, the percentage of senescent cells, secretory interleukin-6, and the expression of SIRT1, AMPK, p53 and p21 were measured.
   Results High glucose (60 mM) significantly decreased cellular viability and increased reactive oxygen species and cellular senescence through the reduction of senescence-associated beta-galactosidase activity. Moreover, high glucose increased the protein levels of p53, acetyl-p53 and p21. The protein levels of SIRT1 and total AMPK were decreased by high glucose. High glucose increased the secretion of IL-6. Alpha-mangostin (1.25 mu M) and metformin (50 mu M) reversed the toxic effects of high glucose in HUVECs.
   Conclusion These results show that alpha-mangostin, similar to metformin, has anti-senescence effects in high-glucose conditions, which is probably due to its antioxidant activity through the SIRT1 pathway. Alpha-mangostin has previously shown anti-inflammatory effects and metabolic status improvement in animal and clinical studies. Therefore, this natural agent can be considered as a supplement to prevent vascular complications caused by high glucose in patients with diabetes.
C1 [Tousian, Hourieh; Razavi, Bibi Marjan; Hosseinzadeh, Hossein] Mashhad Univ Med Sci, Sch Pharm, Dept Pharmacodynamies & Toxicol, Mashhad, Razavi Khorasan, Iran.
   [Razavi, Bibi Marjan] Mashhad Univ Med Sci, Targeted Drug Delivery Res Ctr, Pharmaceut Technol Inst, Mashhad, Razavi Khorasan, Iran.
   [Hosseinzadeh, Hossein] Mashhad Univ Med Sci, Pharmaceut Res Ctr, Pharmaceut Technol Inst, Mashhad, Razavi Khorasan, Iran.
C3 Mashhad University of Medical Sciences; Mashhad University of Medical
   Sciences; Mashhad University of Medical Sciences
RP Hosseinzadeh, H (corresponding author), Mashhad Univ Med Sci, Sch Pharm, Dept Pharmacodynamies & Toxicol, Mashhad, Razavi Khorasan, Iran.; Hosseinzadeh, H (corresponding author), Mashhad Univ Med Sci, Pharmaceut Res Ctr, Pharmaceut Technol Inst, Mashhad, Razavi Khorasan, Iran.
EM houritsh@yahoo.com; RazaviMr@mums.ac.ir; hosseinzadehh@mums.ac.ir
RI tousian, hourieh/AAA-4820-2020; razavi, Bibi Marjan/AAY-5636-2020;
   Hosseinzadeh, Hossein/F-3013-2010
OI Tousian, Hourieh/0000-0001-7760-0301; razavi, Bibi
   Marjan/0000-0002-7450-9286; Hosseinzadeh, Hossein/0000-0002-3483-851X
FU Mashhad University of Medical Sciences [327 941389]
FX This study was financially supported by Mashhad University of Medical
   Sciences (Grant No. 327 941389).
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NR 29
TC 23
Z9 25
U1 0
U2 12
PU SPRINGER INT PUBL AG
PI CHAM
PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND
EI 2008-2231
J9 DARU
JI DARU
PD JUN
PY 2020
VL 28
IS 1
BP 45
EP 55
DI 10.1007/s40199-019-00305-z
EA DEC 2019
PG 11
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA LL8QQ
UT WOS:000500015300001
PM 31792920
OA Green Published
DA 2025-06-11
ER

PT J
AU Chen, TH
   Tsai, MJ
   Fu, YS
   Weng, CF
AF Chen, Ting-Hsu
   Tsai, May-Jywan
   Fu, Yaw-Syan
   Weng, Ching-Feng
TI The Exploration of Natural Compounds for Anti-Diabetes from Distinctive
   Species Garcinia linii with Comprehensive Review of the Garcinia
   Family
SO BIOMOLECULES
LA English
DT Review
DE Garcinia linii; hypoglycemia; benzopyran; triterpene; bioflavonoid;
   phenolic; in silico
ID ALPHA-AMYLASE INHIBITORS; PPAR-GAMMA; INSULIN-RESISTANCE; METABOLIC
   SYNDROME; ENZYME-ACTIVITIES; OXIDATIVE STRESS; CAMBOGIA EXTRACT;
   GLUCOSE-UPTAKE; XANTHONES; MANGOSTANA
AB Approximately 400 Garcinia species are distributed around the world. Previous studies have reported the extracts from bark, seed, fruits, peels, leaves, and stems of Garcinia mangostana, G. xanthochymus, and G. cambogia that were used to treat adipogenesis, inflammation, obesity, cancer, cardiovascular diseases, and diabetes. Moreover, the hypoglycemic effects and underlined actions of different species such as G. kola, G. pedunculata, and G. prainiana have been elucidated. However, the anti-hyperglycemia of G. linii remains to be verified in this aspect. In this article, the published literature was collected and reviewed based on the medicinal characteristics of the species Garcinia, particularly in diabetic care to deliberate the known constituents from Garcinia and further focus on and isolate new compounds of G. linii (Taiwan distinctive species) on various hypoglycemic targets including alpha-amylase, alpha-glucosidase, 5'-adenosine monophosphate-activated protein kinase (AMPK), insulin receptor kinase, peroxisome proliferator-activated receptor gamma (PPAR gamma), and dipeptidyl peptidase-4 (DPP-4) via the molecular docking approach with Gold program to explore the potential candidates for anti-diabetic treatments. Accordingly, benzopyrans and triterpenes are postulated to be the active components in G. linii for mediating blood glucose. To further validate the potency of those active components, in vitro enzymatic and cellular function assays with in vivo animal efficacy experiments need to be performed in the near future.
C1 [Chen, Ting-Hsu] Natl Dong Hwa Univ, Dept Life Sci, Hualien 97401, Taiwan.
   [Chen, Ting-Hsu] Natl Dong Hwa Univ, Inst Biotechnol, Hualien 97401, Taiwan.
   [Tsai, May-Jywan] Taipei Vet Gen Hosp, Neurol Inst, Dept Neurosurg, Neural Regenerat Lab, Taipei 11221, Taiwan.
   [Fu, Yaw-Syan; Weng, Ching-Feng] Kaohsiung Med Univ, Dept Biomed Sci & Environm Biol, Kaohsiung 80708, Taiwan.
   [Fu, Yaw-Syan; Weng, Ching-Feng] Xiamen Med Coll, Inst Resp Dis, Dept Basic Med Sci, Xiamen 361023, Fujian, Peoples R China.
C3 National Dong Hwa University; National Dong Hwa University; Taipei
   Veterans General Hospital; Kaohsiung Medical University; Xiamen Medical
   College
RP Weng, CF (corresponding author), Kaohsiung Med Univ, Dept Biomed Sci & Environm Biol, Kaohsiung 80708, Taiwan.; Weng, CF (corresponding author), Xiamen Med Coll, Inst Resp Dis, Dept Basic Med Sci, Xiamen 361023, Fujian, Peoples R China.
EM 410613031@gms.ndhu.edu.tw; mjtsai2@vghtpe.gov.tw; m805004@kmu.edu.tw;
   cfweng-cfweng@hotmail.com
OI Chen, Ting-Hsu/0000-0002-5596-3600
FU Ministry of Science and Technology, Taiwan [107-2320-B-259-003]
FX This research was funded by Ministry of Science and Technology, Taiwan
   [grant number 107-2320-B-259-003] for C.F. Weng.
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NR 59
TC 17
Z9 18
U1 2
U2 28
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2218-273X
J9 BIOMOLECULES
JI Biomolecules
PD NOV
PY 2019
VL 9
IS 11
AR 641
DI 10.3390/biom9110641
PG 14
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA JV3LN
UT WOS:000502267900002
PM 31652794
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Asprouli, E
   Kalafati, IP
   Sakellari, A
   Karavoltsos, S
   Vlachogiannakos, J
   Revenas, K
   Kokkinos, A
   Dassenakis, M
   Dedoussis, GV
   Kalogeropoulos, N
AF Asprouli, Eleni
   Kalafati, Ioanna Panagiota
   Sakellari, Aikaterini
   Karavoltsos, Sotirios
   Vlachogiannakos, John
   Revenas, Konstantinos
   Kokkinos, Alexander
   Dassenakis, Manos
   Dedoussis, George V.
   Kalogeropoulos, Nick
TI Evaluation of Plasma Trace Elements in Different Stages of Nonalcoholic
   Fatty Liver Disease
SO BIOLOGICAL TRACE ELEMENT RESEARCH
LA English
DT Article
DE Nonalcoholic fatty liver disease (NAFLD); Plasma; Zinc; Cesium;
   Thallium; ICP-MS
ID OXIDATIVE STRESS; NATURAL-HISTORY; RAT MODEL; BLOOD; ZINC; IRON;
   EPIDEMIOLOGY; ASSOCIATION; THALLIUM; METALS
AB Nonalcoholic fatty liver disease (NAFLD) is considered as the hepatic manifestation of metabolic syndrome. Its global prevalence is estimated between 25 and 45%, occurring mainly in overweight individuals with unhealthy dietary habits and low levels of physical activity. Many studies have investigated the association of trace elements with liver diseases, though not with NAFLD. In this work, we investigated trace element levels in plasma of patients and not-patients and their possible association with various stages of the disease. Inductively coupled plasma mass spectrometry (ICP-MS) was employed for the determination of As, Ba, Cd, Co, Cs, Cu, Fe, Rb, Sr, Tl, and Zn in the plasma of 189 free-living residents of Athens, Greece, either healthy or patients with mild, moderate, or severe NAFLD. The disease was diagnosed by abdominal ultrasound; blood samples were analyzed for total, HDL and LDL cholesterol, triglycerides, fasting glucose, fasting insulin, and liver enzymes, namely aspartate aminotransferase (AST), alanine transaminase (ALT), and -glutamyltransferase (Gamma-GT); insulin resistance was determined by the homeostatic model assessment (HOMA-IR). Zinc exhibited a statistically significant negative association with the severity of the disease, while cesium showed a statistically significant positive association. Moreover, thallium and iron were inversely associated with insulin levels. Trace element determination in plasma could be useful for establishing relationships with NAFLD status of patients. Further research is required for the verification and interpretation of these findings.
C1 [Asprouli, Eleni; Kalafati, Ioanna Panagiota; Dedoussis, George V.; Kalogeropoulos, Nick] Harokopio Univ Athens, Sch Hlth Sci & Educ, Dept Nutr & Dietet, Athens, Greece.
   [Asprouli, Eleni; Sakellari, Aikaterini; Karavoltsos, Sotirios; Dassenakis, Manos] Univ Athens, Dept Chem, Lab Environm Chem, Athens, Greece.
   [Vlachogiannakos, John] Univ Athens, Laiko Gen Hosp, Med Sch, Acad Dept Gastroenterol, Athens, Greece.
   [Revenas, Konstantinos] Univ Athens, Laiko Gen Hosp, Med Sch, Radiol Dept, Athens, Greece.
   [Kokkinos, Alexander] Univ Athens, Dept Propaedeut & Internal Med 1, Med Sch, Athens, Greece.
C3 Harokopio University Athens; National & Kapodistrian University of
   Athens; National & Kapodistrian University of Athens; Laiko General
   Hospital; National & Kapodistrian University of Athens; Laiko General
   Hospital; National & Kapodistrian University of Athens
RP Kalogeropoulos, N (corresponding author), Harokopio Univ Athens, Sch Hlth Sci & Educ, Dept Nutr & Dietet, Athens, Greece.
EM nickal@hua.gr
RI Kalafati, Ioanna-Panagiota/AAJ-2287-2020; Kokkinos,
   Alexander/ABI-6657-2020; Dedoussis, George/AAN-7252-2021; KARAVOLTSOS,
   SOTIRIOS/AAC-6047-2021; Kalogeropoulos, Nick/AAN-1087-2021; Dassenakis,
   Manos/AAA-7788-2020; Sakellari, Aikaterini/ADE-5097-2022
OI Sakellari, Aikaterini/0000-0001-6389-5305; Kalogeropoulos,
   Nick/0000-0002-9346-4933; Kalafati, Ioanna Panagiota/0000-0001-5572-7491
FU grant "Obesity and metabolic syndrome: dietary intervention with Greek
   raisins in NAFLD / NASH. Investigation of molecular mechanisms" by the
   Greek Secretariat for Research and Technology [890/2009]
FX This study was supported by the grant "Obesity and metabolic syndrome:
   dietary intervention with Greek raisins in NAFLD / NASH. Investigation
   of molecular mechanisms" reviewed and approved by the Greek Secretariat
   for Research and Technology (Cooperation 890/2009).
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NR 50
TC 35
Z9 36
U1 1
U2 26
PU HUMANA PRESS INC
PI TOTOWA
PA 999 RIVERVIEW DRIVE SUITE 208, TOTOWA, NJ 07512 USA
SN 0163-4984
EI 1559-0720
J9 BIOL TRACE ELEM RES
JI Biol. Trace Elem. Res.
PD APR
PY 2019
VL 188
IS 2
BP 326
EP 333
DI 10.1007/s12011-018-1432-9
PG 8
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA HP9DE
UT WOS:000461991600009
PM 30014284
DA 2025-06-11
ER

PT J
AU Shuai, W
   Kong, B
   Fu, H
   Shen, CJ
   Jiang, XB
   Huang, H
AF Shuai, Wei
   Kong, Bin
   Fu, Hui
   Shen, Caijie
   Jiang, Xiaobo
   Huang, He
TI MD1 Deficiency Promotes Inflammatory Atrial Remodelling Induced by
   High-Fat Diets
SO CANADIAN JOURNAL OF CARDIOLOGY
LA English
DT Article
ID ADIPOSE-TISSUE; METABOLIC SYNDROME; FIBRILLATION; OBESITY; RISK;
   DYSFUNCTION; DIFFERENTIATION; MACROPHAGES; FIBROSIS; STRESS
AB Background: Myeloid differentiation protein 1 (MD1) is expressed in various tissues, including the heart. However, the role of MD1 in obesity-related atrial remodelling remains incompletely understood. Here, this study intends to determine the regulatory role and underlying mechanisms of MD1 in obesity-related atrial remodelling.
   Methods: A high-fat diet (HFD) feeding was performed in 6-week-old MD1-knockout (MD1-KO) mice and wild-type (WT) littermates for 20 weeks. Morphological, biochemical, functional, histological, and electrophysiological studies were conducted at the age of 26 weeks.
   Results: Our results revealed that the MD1 expression levels were downregulated in the atrium of the HFD-fed induced obesity mice. An increase in body weight, glucose intolerance, hyperlipidemia, and adverse atrial remodelling, such as atrial inflammation and fibrosis, were induced by HFD feeding in WT mice. Vulnerability to atrial fibrillation (AF) was also significantly increased by HFD feeding in WT mice. In addition, these adverse effects caused by HFD-fed induced obesity were further exaggerated in MD1-KO mice compared with WT mice. Mechanistically, MD1-KO activated TLR4/NF-kappa B signaling pathways, which led to atrial remodelling in mice fed by HFD by increasing the phosphorylation of p65 and I kappa B alpha.
   Conclusions: Our data suggested that MD1 deficiency played an important role in accelerating the development of inflammatory atrial fibrosis and increasing vulnerability to AF in mice with HFD-fed induced obesity, providing an essential target for improving HFD-induced atrial remodelling.
C1 Wuhan Univ, Dept Cardiol, Renmin Hosp, Cardiovasc Res Inst, Wuhan, Hubei, Peoples R China.
   Hubei Key Lab Cardiol, Wuhan, Hubei, Peoples R China.
C3 Wuhan University
RP Huang, H (corresponding author), Wuhan Univ, Dept Cardiol, Renmin Hosp, 238 Jiefang Rd, Wuhan 430060, Hubei, Peoples R China.
EM huanghe1977@whu.edu.cn
RI huang, he/HAZ-0257-2022
OI Huang, He/0000-0003-3915-2733
FU National Natural Science Foundation of China, China [81570306]; National
   Key R&D Program of China [2017YFC1700500]
FX This work was supported by grants from the National Natural Science
   Foundation of China, China (No. 81570306) and National Key R&D Program
   of China (2017YFC1700500).
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NR 39
TC 41
Z9 42
U1 2
U2 10
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0828-282X
EI 1916-7075
J9 CAN J CARDIOL
JI Can. J. Cardiol.
PD FEB
PY 2019
VL 35
IS 2
BP 208
EP 216
DI 10.1016/j.cjca.2018.11.020
PG 9
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA HK8NY
UT WOS:000458248100016
PM 30760428
DA 2025-06-11
ER

PT J
AU Ko, IG
   Lim, MH
   Choi, PB
   Kim, KH
   Jee, YS
AF Ko, Il Gyu
   Lim, Mi Hee
   Choi, Pil Byung
   Kim, Khae Hawn
   Jee, Yong Seok
TI Effect of Long-term Exercise on Voiding Functions in Obese Elderly Women
SO INTERNATIONAL NEUROUROLOGY JOURNAL
LA English
DT Article
DE Overactive urinary bladder; Obesity; Exercise; Overactive bladder
   symptom score; King's health questionnaire
ID LIFE-STYLE FACTORS; OVERACTIVE BLADDER; URINARY-INCONTINENCE; METABOLIC
   SYNDROME; POSTMENOPAUSAL WOMEN; STRESS-INCONTINENCE; TRAINING AMOUNT;
   BLOOD-PRESSURE; RISK-FACTORS; OVERWEIGHT
AB Purpose: An overactive bladder (OAB) may be defined as urgency that is a sudden, compelling, difficult to defer desire to pass urine that is usually accompanied by frequency and nocturia and possibly by incontinence. Obesity and old age are two factors in various causes of OAB. Several epidemiologic studies have identified positive associations among obesity, old age, urinary incontinence, and OAB. However, although exercise has been known to improve obesity and reduce incontinent urine loss, little research has been done in elderly women. Therefore, we investigated the effects of exercise on obesity-related metabolic factors, blood lipid factors, and OAB symptoms in elderly Korean women.
   Methods: Twenty-one women aged between 69 and 72 years were recruited from the Seoul senior towers in Korea. All subjects worked out on a motorized treadmill and stationary cycle for 40 minutes, respectively, and performed resistance exercise for 30 minutes once a day for 52 weeks. Body composition, blood pressure, blood lipids, OAB symptom score, and King's health questionnaire were investigated and analyzed.
   Results: Before performing physical exercise, all subjects showed increased OAB symptoms in association with enhanced body mass index (BMI), percentage fat, and blood lipid profiles. However, physical exercise for 52 weeks suppressed BMI, percentage fat, and blood lipid profiles and thus improved OAB symptoms.
   Conclusions: We suggest that long-term physical exercise can be a valuable tool for remarkable improvement of OAB.
C1 [Ko, Il Gyu] Kyung Hee Univ, Sch Med, Dept Physiol, Seoul, South Korea.
   [Ko, Il Gyu; Lim, Mi Hee; Jee, Yong Seok] Hanseo Univ, Grad Sch Hlth Promot, Dept Exercise Physiol & Prescript, Seosan, South Korea.
   [Choi, Pil Byung] Yeon Sung Univ, Dept Leisure Sports & Recreat, Anyang, South Korea.
   [Kim, Khae Hawn] Gachon Univ Med & Sci, Gil Hosp, Gachon Univ, Dept Urol, Inchon, South Korea.
C3 Kyung Hee University; Hanseo University; Gachon University
RP Jee, YS (corresponding author), Hanseo Univ, Grad Sch Hlth Promot, Dept Exercise Physiol & Prescript, 46 Hanseo 1 Ro, Haemi Myeon 356706, Seosan, South Korea.
EM jeeys@hanseo.ac.kr
RI Kim, Donghee/C-4288-2013; Jee, Yong-Seok/AAJ-5187-2020
OI Jee, Yong-Seok/0000-0001-6797-0843; Kim, Khae Hawn/0000-0002-7045-8004
FU Hanseo University, Republic of Korea
FX This research was supported by a 2012 grant from Hanseo University,
   Republic of Korea.
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NR 33
TC 16
Z9 18
U1 0
U2 12
PU KOREAN CONTINENCE SOC
PI YEONGOTONG-GU
PA DEPT UROLOGY, AJOU UNIV COLL MEDICINE, SAN 5 WONCHEN-DONG,
   YEONGOTONG-GU, SUWON 443-721, SOUTH KOREA
SN 2093-4777
EI 2093-6931
J9 INT NEUROUROL J
JI Int. Neurourol. J.
PD SEP
PY 2013
VL 17
IS 3
BP 130
EP 138
DI 10.5213/inj.2013.17.3.130
PG 9
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA AM0YN
UT WOS:000339573700007
PM 24143292
OA Green Submitted, gold, Green Published
DA 2025-06-11
ER

PT J
AU Huang, CL
   Wu, YW
   Hsieh, AR
   Hung, YH
   Chen, WJ
   Yang, WS
AF Huang, Chi-Lun
   Wu, Yen-Wen
   Hsieh, Ai-Ru
   Hung, Yu-Hsuan
   Chen, Wen-Jone
   Yang, Wei-Shiung
TI Serum adipocyte fatty acid-binding protein levels in patients with
   critical illness are associated with insulin resistance and predict
   mortality
SO CRITICAL CARE
LA English
DT Article
ID STRESS HYPERGLYCEMIA; ADIPOSE-TISSUE; ILL PATIENTS; OBESITY;
   INFLAMMATION; MACROPHAGES; METABOLISM; EXPRESSION; THERAPY; ADIPOKINES
AB Introduction: Hyperglycemia and insulin resistance are commonplace in critical illness, especially in patients with sepsis. Recently, several hormones secreted by adipose tissue have been determined to be involved in overall insulin sensitivity in metabolic syndrome-related conditions, including adipocyte fatty-acid binding protein (A-FABP). However, little is known about their roles in critical illness. On the other hand, there is evidence that several adipose tissue gene expressions change in critically ill patients.
   Methods: A total of 120 patients (72 with sepsis, 48 without sepsis) were studied prospectively on admission to a medical ICU and compared with 45 healthy volunteers as controls. Various laboratory parameters and metabolic and inflammatory profiles were assessed within 48 hours after admission. Clinical data were collected from medical records.
   Results: Compared with healthy controls, serum A-FABP concentrations were higher in all critically ill patients, and there was a trend of higher A-FABP in patients with sepsis. In multivariate correlation analysis in all critically ill patients, the serum A-FABP concentrations were independently related to serum creatinine, fasting plasma glucose, total cholesterol, TNF-alpha, albumin, and the Acute Physiology and Chronic Health Evaluation II scores. In survival analysis, higher A-FABP levels (> 40 ng/ml) were associated with an unfavorable overall survival outcome, especially in sepsis patients.
   Conclusions: Critically ill patients have higher serum A-FABP concentrations. Moreover, A-FABP may potentially serve as a prognostic biomarker in critically ill patients with sepsis.
C1 [Huang, Chi-Lun] Taoyuan Gen Hosp, Dept Internal Med, Taoyuan 33004, Taiwan.
   [Huang, Chi-Lun; Wu, Yen-Wen; Chen, Wen-Jone; Yang, Wei-Shiung] Natl Taiwan Univ Hosp, Dept Internal Med, Taipei 10002, Taiwan.
   [Huang, Chi-Lun; Hung, Yu-Hsuan; Yang, Wei-Shiung] Natl Taiwan Univ, Coll Med, Grad Inst Clin Med, Taipei 10002, Taiwan.
   [Wu, Yen-Wen] Natl Taiwan Univ Hosp, Dept Nucl Med, Taipei 10002, Taiwan.
   [Wu, Yen-Wen] Far Eastern Mem Hosp, Dept Nucl Med, Taipei 22060, Taiwan.
   [Wu, Yen-Wen] Far Eastern Mem Hosp, Cardiovasc Med Ctr Cardiol, Taipei 22060, Taiwan.
   [Wu, Yen-Wen] Natl Yang Ming Univ, Sch Med, Taipei 11221, Taiwan.
   [Hsieh, Ai-Ru] Acad Sinica, Inst Biomed Sci, Taipei 11529, Taiwan.
   [Chen, Wen-Jone] Natl Taiwan Univ Hosp, Dept Emergency Med, Taipei 10002, Taiwan.
C3 National Taiwan University; National Taiwan University Hospital;
   National Taiwan University; National Taiwan University; National Taiwan
   University Hospital; Far Eastern Memorial Hospital; Far Eastern Memorial
   Hospital; National Yang Ming Chiao Tung University; Academia Sinica -
   Taiwan; National Taiwan University; National Taiwan University Hospital
RP Chen, WJ (corresponding author), Natl Taiwan Univ Hosp, Dept Internal Med, 7 Chung Shan S Rd, Taipei 10002, Taiwan.
EM jone@ntu.edu.tw; wsyang@ntu.edu.tw
RI Chen, Huei-Wen/JAC-7638-2023; Li, Tsai-Chung/P-2052-2015
OI WU, YEN-WEN/0000-0003-1520-1166; CHEN, WEN-JONE/0000-0002-2098-5922;
   YANG, WEI-SHIUNG/0000-0001-5087-373X; HSIEH, AIRU/0000-0003-3900-9101
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NR 34
TC 27
Z9 29
U1 2
U2 14
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1466-609X
EI 1364-8535
J9 CRIT CARE
JI Crit. Care
PY 2013
VL 17
IS 1
AR R22
DI 10.1186/cc12498
PG 7
WC Critical Care Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 161AJ
UT WOS:000320161900073
PM 23375099
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Fierbinteanu-Braticevici, C
   Baicus, C
   Tribus, L
   Papacocea, R
AF Fierbinteanu-Braticevici, Carmen
   Baicus, Cristian
   Tribus, Laura
   Papacocea, Raluca
TI Predictive Factors for Nonalcoholic Steatohepatitis (NASH) in Patients
   with Nonalcoholic Fatty Liver Disease (NAFLD)
SO JOURNAL OF GASTROINTESTINAL AND LIVER DISEASES
LA English
DT Article
DE Nonalcoholic steatohepatitis (NASH); nonalcoholic fatty liver disease
   (NAFLD); predictive factors; fibrosis
ID INSULIN-RESISTANCE; METABOLIC SYNDROME; FIBROSIS; DEFINITION; SEVERITY;
   PROTEIN; SYSTEM
AB Aims: The aim of our study was to assess the clinical and biological parameters associated with Nonalcoholic steatohepatitis (NASH) and to establish the predictors of significant fibrosis in Nonalcoholic fatty liver disease (NAFLD) patients. Methods: We correlated clinical and biochemical parameters with histological features (simple steatosis or steatohepatitis) in 97 patients with NAFLD admitted to the University Hospital Bucharest for persistently raised aminotransferase levels. The biochemical parameters included lipid profile, glucose, liver tests and insulin. The Homeostatic Metabolic Assesment (HOMA)-index and the oxidative stress were also evaluated. Factors associated with NASH and severe fibrosis (F >= 3) were identified using the Mann-Whitney U test and multivariate analysis. The overall validity was measured using the area under receiver operating characteristic curve (AUROC) with 95% CI. Results: At univariate analysis, age, BMI, splenic longitudinal diameter (SLD), HOMA, gamma glutamyl transpeptidase, C-reactive protein (CRP), albumin and INR were significantly associated with histologically proven NASH. The multivariate analysis identified four independent predictive factors for the presence of NASH: CRP (p=0.004), SLD (p=0.018), HOMA (p=0.03) and albumin level (p=0.041). The variables independently associated with severe fibrosis were albumin (p=0.008), blood glucose (p=0.017) and BMI (p=0.048). Conclusion: A predictive model that incorporates the clinical and biological parameters may identify at-risk patients with NAFLD, avoiding liver biopsy on a routine basis.
C1 [Fierbinteanu-Braticevici, Carmen; Tribus, Laura] Univ Hosp Bucharest, Med Clin 2, Bucharest 7001, Romania.
   [Baicus, Cristian] Colentina Hosp, Dept Internal Med, Bucharest, Romania.
   [Baicus, Cristian] Colentina Hosp, RECIF, Bucharest, Romania.
   [Papacocea, Raluca] Carol Davila Univ Med & Pharm, Dept Physiol 1, Bucharest, Romania.
C3 Carol Davila University of Medicine & Pharmacy
RP Fierbinteanu-Braticevici, C (corresponding author), Univ Hosp Bucharest, Med Clin 2, Bucharest 7001, Romania.
EM cfierbinteanu@yahoo.com
RI Tribus, Laura/GLU-7404-2022; Fierbinteanu Braticevici,
   Carmen/AAM-1306-2020; Baicus, Cristian/C-3355-2008
OI Baicus, Cristian/0000-0002-7954-0098; Fierbinteanu-Braticevici,
   Carmen/0000-0001-8863-3301
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NR 32
TC 35
Z9 38
U1 0
U2 12
PU MEDICAL UNIV PRESS
PI CLUJ-NAPOCA
PA 3RD MEDICAL CLINIC, STR CROITORILOR NO 19-21, CLUJ-NAPOCA, 400162,
   ROMANIA
SN 1841-8724
EI 1842-1121
J9 J GASTROINTEST LIVER
JI J. Gastrointest. Liver Dis.
PD JUN
PY 2011
VL 20
IS 2
BP 153
EP 159
PG 7
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 793DS
UT WOS:000292801200010
PM 21725512
DA 2025-06-11
ER

PT J
AU Polyzos, SA
   Kountouras, J
   Zavos, C
AF Polyzos, Stergios A.
   Kountouras, Jannis
   Zavos, Christos
TI Nonalcoholic Fatty Liver Disease: The Pathogenetic Roles of Insulin
   Resistance and Adipocytokines
SO CURRENT MOLECULAR MEDICINE
LA English
DT Review
DE Adipocytokine; adipocyte; adiponectin; insulin resistance; leptin;
   nonalcoholic fatty liver disease; nonalcoholic steatohepatitis; tumor
   necrosis factor-alpha
ID ACYLATION-STIMULATING PROTEIN; NECROSIS-FACTOR-ALPHA; RETINOL-BINDING
   PROTEIN-4; NF-KAPPA-B; METABOLIC SYNDROME; ADIPOSE-TISSUE; TNF-ALPHA;
   GENE-EXPRESSION; SERUM RETINOL-BINDING-PROTEIN-4; WEIGHT-LOSS
AB Nonalcoholic fatty liver disease (NAFLD) encompasses a spectrum of common hepatic disorders in western countries, with multiple consequences and its incidence is paralleling the increasing numbers of overweight and obese individuals worldwide. The pathogenesis of NAFLD is thought to be related mainly with insulin resistance (IR) syndrome and oxidative stress; the latter resulting from mitochondrial fatty acids (FFAs) oxidation, nuclear factor-kappaB (NF kappa B)-dependent inflammatory cytokine expression and adipocytokines may promote hepatocellular damage, inflammation, fibrosis and progressive liver disease.
   Adipocytokines and other recognized cytokines produced partially by inflammatory cells infiltrating adipose tissue, play an important role in the pathogenesis of IR and NAFLD, through complex and interactive paracrine and endocrine mechanisms. Some adipocytokines, including adiponectin and leptin decrease IR, while others, including tumor necrosis factor (TNF)-alpha, interleukin (IL)-6 and resistin enhance IR. The multi-hit hypothesis provides a model that summarizes the complex factors and interactions leading from adipocytokines, FFAs metabolism and IR to NAFLD.
   This review outlines the pathways involved in adipocytokines, IR and NAFLD sequence; the first part describes the impaired IR pathway leading to NAFLD and the second part the mechanisms by which adipocytokines influence IR and NAFLD development and progression. Understanding these complex mechanisms has evoked new therapeutic approaches, which may provide promising results to date.
C1 [Polyzos, Stergios A.; Kountouras, Jannis; Zavos, Christos] Aristotle Univ Thessaloniki, Dept Med, Med Clin 2, Ippokrat Hosp, GR-54006 Thessaloniki, Greece.
C3 Aristotle University of Thessaloniki
RP Kountouras, J (corresponding author), 8 Fanariou St, Thessaloniki 55133, Greece.
EM jannis@med.auth.gr
RI Polyzos, Stergios/H-2844-2019; Zavos, Christos/N-8618-2015
OI Polyzos, Stergios/0000-0001-9232-4042; Zavos,
   Christos/0000-0002-3443-7791
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NR 172
TC 261
Z9 292
U1 3
U2 55
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1566-5240
EI 1875-5666
J9 CURR MOL MED
JI Curr. Mol. Med.
PD APR
PY 2009
VL 9
IS 3
BP 299
EP 314
DI 10.2174/156652409787847191
PG 16
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 440JP
UT WOS:000265696900006
PM 19355912
DA 2025-06-11
ER

PT J
AU Parekh, S
   Anania, FA
AF Parekh, Samir
   Anania, Frank A.
TI Abnormal lipid and glucose metabolism in obesity: Implications for
   nonalcoholic fatty liver disease
SO GASTROENTEROLOGY
LA English
DT Review
ID HEPATIC INSULIN-RESISTANCE; ENDOPLASMIC-RETICULUM STRESS;
   NECROSIS-FACTOR-ALPHA; WHITE ADIPOSE-TISSUE; HEPATOCELLULAR-CARCINOMA;
   NATURAL-HISTORY; WEIGHT-LOSS; CRYPTOGENIC CIRRHOSIS; ALANINE
   AMINOTRANSFERASE; ACUTE HYPERINSULINEMIA
AB Nonalcoholic fatty liver disease represents a spectrum of histopathologic abnormalities, the prevalence of which may be as high as 24% of the population of the United States. Nonalcoholic fatty liver disease will play a major role in the science and practice of gastroenterology in the near future. The fundamental derangement in nonalcoholic fatty liver disease is insulin resistance, a key component of the metabolic syndrome, which includes type 2 diabetes mellitus, hypertriglyceridemia, essential hypertension, low circulating high-density lipoprotein, and obesity. The natural,history of fatty liver disease is not always benign, and causality for cirrhosis and chronic liver disease is well-founded in the literature. Treatment strategies are limited and, at present, are primarily focused on weight loss and use of insulin sensitizing agents, including the thiazolidenediones. Recent data clearly implicate hepatic insulin resistance as a culprit in accumulation of free fatty acids as triglycerides in hepatocytes. Hepatic insulin resistance is clearly exacerbated by systemic insulin resistance and impaired handling by skeletal muscle and adipose tissue of both glucose and free fatty acids. The key consequence of hepatic insulin resistance, impaired hepatocyte insulin signal transduction, results in adverse cellular and molecular changes exacerbating hepatocyte triglyceride storage. Cytokines secreted by white adipose tissue, adipokines, have emerged as key players in glucose and fat metabolism previously thought controlled largely by insulin. Modulation of adipokines may aid in further understanding of the pathophysiology and treatment of nonalcoholic fatty liver disease.
C1 Emory Univ, Sch Med, Dept Med, Div Digest Dis, Atlanta, GA 30322 USA.
C3 Emory University
RP Anania, FA (corresponding author), Room 248,615 Michael St, Atlanta, GA 30322 USA.
EM fanania@emory.edu
FU NIDDK NIH HHS [DK062092, DK 064399, DK075397] Funding Source: Medline
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NR 162
TC 256
Z9 283
U1 0
U2 37
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0016-5085
EI 1528-0012
J9 GASTROENTEROLOGY
JI Gastroenterology
PD MAY
PY 2007
VL 132
IS 6
BP 2191
EP 2207
DI 10.1053/j.gastro.2007.03.055
PG 17
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 166UA
UT WOS:000246404700009
PM 17498512
OA Bronze
DA 2025-06-11
ER

PT J
AU Easton, ZJW
   Delhaes, F
   Mathers, K
   Zhao, L
   Vanderboor, CMG
   Regnault, TRH
AF Easton, Zachary J. W.
   Delhaes, Flavien
   Mathers, Katherine
   Zhao, Lin
   Vanderboor, Christina M. G.
   Regnault, Timothy R. H.
TI Syncytialization and prolonged exposure to palmitate impacts BeWo
   respiration
SO REPRODUCTION
LA English
DT Article
ID TO-HIP RATIO; MATERNAL OBESITY; METABOLIC SYNDROME; PREGNANT-WOMEN;
   FATTY-ACIDS; OLEATE; APOPTOSIS; CELLS; DIET; TROPHOBLAST
AB Placental villous trophoblast mitochondrial respiratory function is critical for a successful pregnancy and environmental influences such as maternal obesity have been associated with respiratory impairment at term. More recently, a gestational high fat diet independent of maternal body composition, has been highlighted as a potential independent regulator of placental mitochondria! metabolism. The current study aimed to characterize the direct impact of a prolonged and isolated exposure to the dietary fatty acids Palmitate (PA) and Oleate (OA) upon placental cell mitochondria! respiratory function. BeWo cytotrophoblast (CT) and syncytiotrophoblast (SCT) cells were treated for 72 h with 100 mu M PA, OA or PA+OA (P/O). Live-cell metabolic function was analyzed via the Seahorse XF Mito and Glycolysis Stress tests. Immunoblots and spectrophotometric activity assays were utilized to examine the protein expression and function of electron transport chain (ETC) complexes and key mitochondria! regulatory enzymes. Syncytialization of BeWo cells resulted reduced respiratory activity in conjunction with altered complex I and II activity and decreased pyruvate dehydrogenase (PDH) protein expression and activity. PA and P/O treatments were associated with increased basal and maximal respiratory activities in BeWo CT cells without alterations in protein expression or activity of individual ETC complexes and mitochondria! substrate regulators. The metabolic suppression in BeWo SCTs was consistent with that previously observed in primary human trophoblast cell cultures, while the observed increases in respiratory activity in PA-treated BeWo CTs may be indicative of an early timepoint of specific dietary saturated fat-mediated placental cell mitochondria! dysfunction.
C1 [Easton, Zachary J. W.; Delhaes, Flavien; Mathers, Katherine; Zhao, Lin; Vanderboor, Christina M. G.; Regnault, Timothy R. H.] Western Univ, Dept Physiol & Pharmacol, London, ON, Canada.
   [Regnault, Timothy R. H.] Western Univ, Dept Obstet & Gynaecol, London, ON, Canada.
   [Regnault, Timothy R. H.] Childrens Hlth Res Inst, London, ON, Canada.
   [Regnault, Timothy R. H.] Lawson Hlth Res Inst, London, ON, Canada.
C3 Western University (University of Western Ontario); Western University
   (University of Western Ontario); Western University (University of
   Western Ontario); University Western Ontario Hospital
RP Regnault, TRH (corresponding author), Western Univ, Dept Physiol & Pharmacol, London, ON, Canada.; Regnault, TRH (corresponding author), Western Univ, Dept Obstet & Gynaecol, London, ON, Canada.; Regnault, TRH (corresponding author), Childrens Hlth Res Inst, London, ON, Canada.; Regnault, TRH (corresponding author), Lawson Hlth Res Inst, London, ON, Canada.
EM tim.regnault@uwo.ca
RI Regnault, Timothy/J-8902-2014
OI Regnault, Timothy/0000-0003-1930-8358; Easton,
   Zachary/0000-0002-9319-0207
FU National Institutes of Health (NIH) Human Placenta Project Grant [U01
   HD087181-01]; Obstetrics & Gynaecology Graduate Scholarship (OGGS) -
   Obstetrics & Gynaecology Department at Western University
FX This research was supported by funds from a National Institutes of
   Health (NIH) Human Placenta Project Grant (grant No. U01 HD087181-01).
   Zachary Easton was supported by funds from an Obstetrics & Gynaecology
   Graduate Scholarship (OGGS) awarded by the Obstetrics & Gynaecology
   Department at Western University.
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NR 73
TC 7
Z9 9
U1 0
U2 6
PU BIOSCIENTIFICA LTD
PI BRISTOL
PA STARLING HOUSE, 1600 BRISTOL PARKWAY N, BRISTOL, ENGLAND
SN 1470-1626
J9 REPRODUCTION
JI Reproduction
PD JAN
PY 2021
VL 161
IS 1
BP 73
EP 88
DI 10.1530/REP-19-0433
PG 16
WC Developmental Biology; Reproductive Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Developmental Biology; Reproductive Biology
GA PS2GG
UT WOS:000607745900013
PM 33151905
OA Green Accepted, Bronze, Green Submitted
DA 2025-06-11
ER

PT J
AU Yildirim, OG
   Sadi, G
   Akar, F
AF Yildirim, Onur Gokhan
   Sadi, Gokhan
   Akar, Fatma
TI Lactobacillus plantarum and Lactobacillus helveticus
   modulate SIRT1, Caspase3 and Bcl-2 in the testes of high-fructose-fed
   rats
SO ISTANBUL JOURNAL OF PHARMACY
LA English
DT Article
DE Dietary fructose; Lactobacillus plantarum; Lactobacillus helveticus;
   apoptosis; testes
ID INDUCED DIABETES INCREASES; INSULIN-RESISTANCE; OXIDATIVE STRESS;
   TESTICULAR DYSFUNCTION; METABOLIC SYNDROME; ZINC-DEFICIENCY; CELL
   APOPTOSIS; STREPTOZOTOCIN; RESVERATROL; ACTIVATION
AB Background and Aims: The influence of a high-fructose diet and probiotics on the mate reproductive system and the testicular apoptotic pathway has been poorly documented. In this study, we aimed to investigate the influence of Lactobacillus plantarum and Lactobacillus helveticus supplementation on apoptotic factors such as sirtuin1, caspase3 and bcl-2 on the testicular tissue of high-fructose-fed rats.
   Methods: Fructose was given to the rats as a 20% solution in drinking water for 15 weeks. Gene expressions were established by real-time PCR. Protein levels were determined by Western blot analysis.
   Results: Fructose consumption did not change mRNA expression of SIRT1, but did resulted in a decreased protein level. Dietary fructose reduced bcl-2 mRNA and protein expressions, whereas no changes were observed in the gene and protein expression levels of factor caspase-3. Both Lactobacillus supplementations increased SIRT1 protein expression without changing the mRNA levels in fructose-fed rats. The supplementations with both probiotics produced a significant downregulation on caspase3 mRNA and protein levels. Bcl-2 proetin level increases with both probiotics supplementation white, mRNA level did not show difference in L.plantarum, but increased in L. helveticus supplementation.
   Conclusion: Treatments with L.plantarum and L.helveticus can reduce testicular apoptosis induced by dietary high-fructose in rats via suppressing caspase3 and promoting sirt1 and bcl-2 protein expressions.
C1 [Yildirim, Onur Gokhan] Artvin Coruh Univ, Vocat Sch Hlth Serv, Dept Pharm Serv, Artvin, Turkey.
   [Sadi, Gokhan] Karamanoglu Mehmetbey Univ, KO Sci Fac, Dept Biol, Karaman, Turkey.
   [Akar, Fatma] Gazi Univ, Fac Pharm, Dept Pharmacol, Ankara, Turkey.
C3 Artvin Coruh University; Karamanoglu Mehmetbey University; Gazi
   University
RP Yildirim, OG (corresponding author), Artvin Coruh Univ, Vocat Sch Hlth Serv, Dept Pharm Serv, Artvin, Turkey.
EM ogyildirim@artvin.edu.tr
RI Sadi, Gökhan/AAK-5468-2021; YILDIRIM, Onur Gokhan/AAA-9156-2022; Akar,
   Fatma/D-1650-2018
OI YILDIRIM, ONUR GOKHAN/0000-0003-0090-7369; Akar,
   Fatma/0000-0002-5432-0304; Sadi, Gokhan/0000-0002-6422-1203
FU Gazi University Research Fund [BAP 02/2017-20]
FX This work was supported by the Gazi University Research Fund under Grant
   [BAP 02/2017-20].
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NR 67
TC 2
Z9 2
U1 1
U2 18
PU ISTANBUL UNIV, FAC PHARMACY
PI ISTANBUL
PA DEPT PHARMACEUTICAL TECHNOLOGY, ISTANBUL, 34116, TURKEY
EI 2587-2087
J9 ISTANB J PHARM
JI Istanb. J. Pharm.
PD DEC
PY 2020
VL 50
IS 3
BP 168
EP 175
DI 10.26650/IstanbulJPharm.2020.0076
PG 8
WC Pharmacology & Pharmacy
WE Emerging Sources Citation Index (ESCI)
SC Pharmacology & Pharmacy
GA PO7OC
UT WOS:000605357000003
OA gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Carotti, S
   Aquilano, K
   Zalfa, F
   Ruggiero, S
   Valentini, F
   Zingariello, M
   Francesconi, M
   Perrone, G
   Alletto, F
   Antonelli-Incalzi, R
   Picardi, A
   Morini, S
   Lettieri-Barbato, D
   Vespasiani-Gentilucci, U
AF Carotti, Simone
   Aquilano, Katia
   Zalfa, Francesca
   Ruggiero, Sergio
   Valentini, Francesco
   Zingariello, Maria
   Francesconi, Maria
   Perrone, Giuseppe
   Alletto, Francesca
   Antonelli-Incalzi, Raffaele
   Picardi, Antonio
   Morini, Sergio
   Lettieri-Barbato, Daniele
   Vespasiani-Gentilucci, Umberto
TI Lipophagy Impairment Is Associated With Disease Progression in NAFLD
SO FRONTIERS IN PHYSIOLOGY
LA English
DT Article
DE autophagy; high-fat diet; lipolysosomes; non-alcoholic steatohepatitis;
   lipophagy
ID FATTY LIVER-DISEASE; LIPID DROPLETS; NONALCOHOLIC STEATOHEPATITIS;
   RISK-FACTORS; AUTOPHAGY; LIPOLYSOSOMES; EPIDEMIOLOGY; CHOLESTEROL;
   DYSFUNCTION; POPULATION
AB Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in Western countries and is associated with aging and features of metabolic syndrome. Lipotoxicity and oxidative stress are consequent to dysregulation of lipid metabolism and lipid accumulation, leading to hepatocyte injury and inflammation. Lipophagy consists in selective degradation of intracellular lipid droplets by lysosome and mounting evidence suggests that lipophagy is dysregulated in NAFLD. Here we demonstrate lipophagy impairment in experimental models of NAFLD and in a NAFLD patient cohort by histomorphological and molecular analysis. High fat diet-fed C57BL/6J male mice and high-fat/high-glucose cultured Huh7 cells showed accumulation of both p62/SQSTM1 and LC3-II protein. In 59 NAFLD patients, lipid droplet-loaded lysosomes/lipolysosomes and p62/SQSTM1 clusters correlated with NAFLD activity score (NAS) and with NAS and fibrosis stage, respectively, and levels of expression of lysosomal genes, as well as autophagy-related genes, correlated with NAS and fibrosis stage. An increased amount of lipid droplets, lipolysosomes and autophagosomes was found in subjects with NAFLD compared to healthy subjects at ultrastructural level. In conclusion, here we observed that NAFLD is characterized by histological, ultrastructural and molecular features of altered autophagy that is associated with an impaired lipid degradation. Impaired autophagy is associated with features of advanced disease. Lipopolysosomes, as individuated with light microscopy, should be further assessed as markers of disease severity in NAFLD patients.
C1 [Carotti, Simone; Zalfa, Francesca; Ruggiero, Sergio; Valentini, Francesco; Zingariello, Maria; Francesconi, Maria; Morini, Sergio] Univ Campus Biomed, Lab Microscop & Ultrastruct Anat, Rome, Italy.
   [Carotti, Simone; Zalfa, Francesca; Perrone, Giuseppe] Campus Biomed Univ Hosp, Predict Mol Diagnost Div, Dept Pathol, Rome, Italy.
   [Aquilano, Katia; Lettieri-Barbato, Daniele] Univ Roma Tor Vergata, Dept Biol, Rome, Italy.
   [Perrone, Giuseppe] Univ Campus Biomed, Res Unit Pathol, Rome, Italy.
   [Alletto, Francesca; Antonelli-Incalzi, Raffaele; Picardi, Antonio; Vespasiani-Gentilucci, Umberto] Univ Campus Biomed, Internal Med Geriatr & Hepatol Unit, Rome, Italy.
   [Lettieri-Barbato, Daniele] IRCCS Fdn Santa Lucia, Rome, Italy.
C3 University Campus Bio-Medico - Rome Italy; University Campus Bio-Medico
   - Rome Italy; Fondazione Policlinico Universitario Campus Bio-Medico;
   University of Rome Tor Vergata; University Campus Bio-Medico - Rome
   Italy; University Campus Bio-Medico - Rome Italy; IRCCS Santa Lucia
RP Carotti, S (corresponding author), Univ Campus Biomed, Lab Microscop & Ultrastruct Anat, Rome, Italy.; Carotti, S (corresponding author), Campus Biomed Univ Hosp, Predict Mol Diagnost Div, Dept Pathol, Rome, Italy.; Aquilano, K (corresponding author), Univ Roma Tor Vergata, Dept Biol, Rome, Italy.
EM s.carotti@unicampus.it; katia.aquilano@uniroma2.it
RI Incalzi, Raffaele/G-3978-2012; Perrone, Giuseppe/GLR-7098-2022;
   Ruggiero, Sergio/AEV-8946-2022; Barbato, Daniele/K-8759-2016; Morini,
   Sergio/AAB-8540-2022; Carotti, Simone/G-7822-2012; Perrone,
   Giuseppe/E-7062-2011; AQUILANO, KATIA/K-8888-2016
OI Perrone, Giuseppe/0000-0002-9538-5729; Ruggiero,
   Sergio/0000-0002-4223-2817; AQUILANO, KATIA/0000-0002-5905-9870; Morini,
   Sergio/0000-0001-6137-2404
FU European Foundation for the Studies on Diabetes
FX This work was partially supported by funds from European Foundation for
   the Studies on Diabetes to DL-B.
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NR 42
TC 84
Z9 93
U1 0
U2 32
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1664-042X
J9 FRONT PHYSIOL
JI Front. Physiol.
PD JUL 17
PY 2020
VL 11
AR 850
DI 10.3389/fphys.2020.00850
PG 12
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA NA8YX
UT WOS:000560105500001
PM 32765301
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Villarroya, F
   Cereijo, R
   Gavaldà-Navarro, A
   Villarroya, J
   Giralt, M
AF Villarroya, F.
   Cereijo, R.
   Gavalda-Navarro, A.
   Villarroya, J.
   Giralt, M.
TI Inflammation of brown/beige adipose tissues in obesity and metabolic
   disease
SO JOURNAL OF INTERNAL MEDICINE
LA English
DT Article
DE brown adipose; cytokine; inflammation; macrophage; obesity
ID NECROSIS-FACTOR-ALPHA; DIET-INDUCED OBESITY; ALTERNATIVELY ACTIVATED
   MACROPHAGES; CORONARY-ARTERY-DISEASE; INSULIN-RESISTANCE; TNF-ALPHA;
   PROINFLAMMATORY PHENOTYPE; BROWN ADIPOCYTES; IMMUNE CELLS; PERIVASCULAR
   ADIPOCYTES
AB Many of the comorbidities of obesity, including type 2 diabetes and cardiovascular diseases, are related to the low-grade chronic inflammation of white adipose tissue. Under white adipocyte stress, local infiltration of immune cells and enhanced production of pro-inflammatory cytokines together reduce metabolic flexibility and lead to insulin resistance in obesity. Whereas white adipocytes act in energy storage, brown and beige adipocytes specialize in energy expenditure. Brown and beige activity protects against obesity and associated metabolic disorders, such as hyperglycaemia and hyperlipidaemia. Compared to white fat, brown adipose tissue depots are less susceptible to developing local inflammation in response to obesity; however, strong obesogenic insults ultimately induce a locally pro-inflammatory environment in brown fat. This condition directly alters the thermogenic activity of brown fat by impairing its energy expenditure mechanism and uptake of glucose for use as a fuel substrate. Pro-inflammatory cytokines also impair beige adipogenesis, which occurs mainly in subcutaneous adipose tissue. There is evidence that inflammatory processes occurring in perivascular adipose tissues alter their brown-versus-white plasticity, impair the extent of browning in these depots and favour the local release of vasculature damaging signals. In summary, the targeting of brown and beige adipose tissues by pro-inflammatory signals and the subsequent impairment of their thermogenic and metabolite draining activities appears to represent obesity-driven disturbances that contribute to metabolic syndrome and cardiovascular alterations in obesity.
C1 [Villarroya, F.; Cereijo, R.; Gavalda-Navarro, A.; Villarroya, J.; Giralt, M.] Univ Barcelona, Inst Biomed, CIBER Fisiopatol Obesidad & Nutr, Dept Biochem & Mol Biomed, Barcelona, Spain.
   [Villarroya, F.; Cereijo, R.; Gavalda-Navarro, A.; Villarroya, J.; Giralt, M.] Inst Recerca St Joan de Deu, Barcelona, Spain.
   [Villarroya, J.] Inst Recerca Hosp Santa Creu & St Pau, Barcelona, Spain.
C3 CIBER - Centro de Investigacion Biomedica en Red; CIBEROBN; University
   of Barcelona; Hospital of Santa Creu i Sant Pau
RP Villarroya, F (corresponding author), Univ Barcelona, Fac Biol, Dept Bioquim & Biomed Mol, Avda Diagonal 643, E-08028 Barcelona, Spain.
EM fvillarroya@ub.edu
RI Gavaldà-Navarro, Aleix/C-5074-2017; Villarroya, Francesc/K-4357-2014;
   Villarroya, Joan/W-4066-2018; Cereijo, Ruben/K-3556-2017; Giralt,
   Marta/A-4756-2013
OI Cereijo, Ruben/0000-0002-1108-230X; Gavalda-Navarro,
   Aleix/0000-0001-8421-3174; Giralt, Marta/0000-0001-7968-4190;
   Villarroya, Francesc/0000-0003-1266-9142
FU Ministerio de Economia y Competitividad (MINECO), Spain [SAF2017-85722,
   PI17/00420]; European Regional Development Fund (ERDF)
FX This work was supported by grants from the Ministerio de Economia y
   Competitividad (MINECO), Spain (SAF2017-85722 and PI17/00420),
   co-financed by the European Regional Development Fund (ERDF). JV is a
   "Juan de la Cierva" (MINECO, Spain) postdoctoral researcher.
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NR 100
TC 224
Z9 247
U1 7
U2 69
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0954-6820
EI 1365-2796
J9 J INTERN MED
JI J. Intern. Med.
PD NOV
PY 2018
VL 284
IS 5
BP 492
EP 504
DI 10.1111/joim.12803
PG 13
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA GX5GN
UT WOS:000447772700005
PM 29923291
OA Bronze
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Pertl, L
   Mossböck, G
   Wedrich, A
   Weger, M
   Königsbrügge, O
   Silbernagel, G
   Posch, F
AF Pertl, Laura
   Mossboeck, Georg
   Wedrich, Andreas
   Weger, Martin
   Koenigsbruegge, Oliver
   Silbernagel, Guenther
   Posch, Florian
TI Triglycerides and Open Angle Glaucoma - A Meta-analysis with
   meta-regression
SO SCIENTIFIC REPORTS
LA English
DT Article
ID DENSITY-LIPOPROTEIN-CHOLESTEROL; VASCULAR RISK-FACTORS; NUTRITION
   EXAMINATION SURVEY; OCULAR BLOOD-FLOW; INTRAOCULAR-PRESSURE;
   NATIONAL-HEALTH; METABOLIC SYNDROME; OXIDATIVE STRESS; TOPICAL TIMOLOL;
   SERUM-LIPIDS
AB Although intraocular pressure is the main the risk factor for the development of glaucoma, other risk factors such as vascular dysfunction might play an additional pathogenic role. Hypertriglyceridemia, which may lead to vascular dysfunction, has been implicated in the development of glaucoma. The objective of this meta-analysis was to investigate the association of triglyceride levels with the risk of glaucoma in case-control studies. Seventeen case-control studies were included investigating the difference in triglyceride levels in patients with glaucoma (N = 1 391) compared to subjects without glaucoma (N = 25 575). In random effects meta-analysis, the pooled mean triglyceride level across all studies and patients with and without glaucoma was 132.9 mg/dL (95%CI: 124.0-141.7). Patients with glaucoma had significantly higher mean triglyceride levels than patients without glaucoma (absolute difference = 14.2 mg/dL, 95%CI: 5.8-22.5, p < 0.0001). A considerable amount of heterogeneity of included studies was observed (I-2 = 66.2%, heterogeneity chi(2) = 47.4 on 16 degrees of freedom, p < 0.0001). In conclusion, this meta-analysis of case-control studies found that patients with glaucoma had higher mean triglyceride levels than patients without glaucoma. This finding is consistent with the concept that hypertriglyceridemia represents an additional risk factor for glaucoma. Whether this association is causal and/or might be modified by glaucoma medications remains to be investigated.
C1 [Pertl, Laura; Mossboeck, Georg; Wedrich, Andreas; Weger, Martin] Med Univ Graz, Dept Ophthalmol, Auenbruggerpl 4, A-8036 Graz, Austria.
   [Koenigsbruegge, Oliver] Med Univ Vienna, Dept Med 1, Clin Div Haematol & Haemostaseol, Wahringer Gurtel 18-20, A-1090 Vienna, Austria.
   [Silbernagel, Guenther] Med Univ Graz, Div Angiol, Dept Internal Med, Auenbruggerpl 15, A-8036 Graz, Austria.
   [Posch, Florian] Med Univ Graz, Dept Internal Med, Div Oncol, Auenbruggerpl 15, A-8036 Graz, Austria.
C3 Medical University of Graz; Medical University of Vienna; Medical
   University of Graz; Medical University of Graz
RP Pertl, L (corresponding author), Med Univ Graz, Dept Ophthalmol, Auenbruggerpl 4, A-8036 Graz, Austria.
EM laura.pertl@medunigraz.at
RI Wedrich, Andreas/AAE-9171-2020
OI Posch, Florian/0000-0002-0448-6314; Silbernagel,
   Guenther/0000-0001-9323-329X
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NR 45
TC 21
Z9 21
U1 0
U2 3
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD AUG 10
PY 2017
VL 7
AR 7829
DI 10.1038/s41598-017-08295-1
PG 9
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA FD2YK
UT WOS:000407400500061
PM 28798341
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Ji, CP
   Li, YP
   Cui, LF
   Cai, JF
   Shi, JH
   Cheng, FW
   Li, YQ
   Curhan, GC
   Wu, SL
   Gao, X
AF Ji, Chunpeng
   Li, Yanping
   Cui, Liufu
   Cai, Jianfang
   Shi, Jihong
   Cheng, Feon W.
   Li, Yuqing
   Curhan, Gary C.
   Wu, Shouling
   Gao, Xiang
TI Prenatal Earthquake Exposure and Midlife Uric Acid Levels Among Chinese
   Adults
SO ARTHRITIS CARE & RESEARCH
LA English
DT Article
ID METABOLIC SYNDROME; HYPERURICEMIA; DEXAMETHASONE; HYPERTENSION;
   ASSOCIATION; WOMEN
AB ObjectiveTo test whether prenatal exposure to earthquake (as a surrogate for acute prenatal stress) could have unfavorable effects on uric acid levels later in life.
   MethodsWe included 536 individuals who had been prenatally exposed to the Tangshan earthquake in 1976, and 536 sex- and age-matched individuals without that exposure. Serum uric acid concentrations were measured based on fasting blood samples, which were repeatedly collected in 2006, 2008, and 2010. Mean uric acid concentrations in 2010 and the increasing rate from 2006 to 2010 were compared between the 2 groups, after adjustment for age, sex, body mass index, serum concentrations of glucose, triglycerides, C-reactive protein level, estimated glomerular filtration rate, and other potential confounders. We also used multiple logistic regression to estimate the risk of hyperuricemia (>416 mole/liter in men or >357 mole/liter in women) in 2010 by calculating the odds ratios (ORs) and 95% confidence intervals (95% CIs) after adjustment for the previously mentioned covariates.
   ResultsParticipants with prenatal exposure to the earthquake had higher concentrations of serum uric acid (adjusted means 315 mole/liter versus 296 mole/liter; P=0.001) and a higher likelihood of having hyperuricemia (multivariate adjusted OR 1.70 [95% CI 1.09-2.66]) in 2010 relative to those without the exposure. Prenatal exposure to the earthquake was consistently significantly associated with a faster increase in uric acid concentration from 2006 to 2010 (P<0.001).
   ConclusionPrenatal exposure to the earthquake was associated with higher serum uric acid and higher odds of hyperuricemia in early adulthood.
C1 [Ji, Chunpeng; Cui, Liufu; Shi, Jihong; Li, Yuqing; Wu, Shouling] Hebei United Univ, Kailuan Gen Hosp, Tangshan, Hebei, Peoples R China.
   [Li, Yanping] Harvard Sch Publ Hlth, Boston, MA USA.
   [Cai, Jianfang] Peking Union Med Coll Hosp, Beijing, Peoples R China.
   [Cheng, Feon W.; Gao, Xiang] Penn State Univ, State Coll, PA USA.
   [Curhan, Gary C.] Brigham & Womens Hosp, 75 Francis St, Boston, MA 02115 USA.
   [Curhan, Gary C.] Harvard Med Sch, Boston, MA USA.
C3 North China University of Science & Technology; Harvard University;
   Harvard T.H. Chan School of Public Health; Chinese Academy of Medical
   Sciences - Peking Union Medical College; Peking Union Medical College
   Hospital; Pennsylvania Commonwealth System of Higher Education (PCSHE);
   Pennsylvania State University; Pennsylvania State University -
   University Park; Harvard University; Harvard University Medical
   Affiliates; Brigham & Women's Hospital; Harvard University; Harvard
   Medical School
RP Gao, X (corresponding author), Penn State Univ, Dept Nutr Sci, 109 Chandlee Lab, University Pk, PA 16802 USA.
EM xxg14@psu.edu
RI Shi, Jihong/KHZ-0655-2024; Ji, chunpeng/KAM-0103-2024; Gao,
   Xiang/KFQ-2812-2024; Li, Yanping/H-6437-2011
OI Gao, Xiang/0000-0003-2617-6509; Li, Yanping/0000-0002-0412-2748
FU National Natural Science Foundation of China [81170244, 81170090]
FX Supported by the National Natural Science Foundation of China (grants
   81170244 and 81170090).
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NR 25
TC 7
Z9 8
U1 0
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2151-464X
EI 2151-4658
J9 ARTHRIT CARE RES
JI Arthritis Care Res.
PD MAY
PY 2017
VL 69
IS 5
BP 703
EP 708
DI 10.1002/acr.22973
PG 6
WC Rheumatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Rheumatology
GA ET3GK
UT WOS:000400165500012
PM 27454342
OA Bronze
DA 2025-06-11
ER

PT J
AU Dalmasso, C
   Maranon, R
   Patil, C
   Bui, E
   Moulana, M
   Zhang, HW
   Smith, A
   Cardozo, LLY
   Reckelhoff, JF
AF Dalmasso, Carolina
   Maranon, Rodrigo
   Patil, Chetan
   Bui, Elizabeth
   Moulana, Mohadetheh
   Zhang, Howei
   Smith, Andrew
   Cardozo, Licy L. Yanes
   Reckelhoff, Jane F.
TI Cardiometabolic Effects of Chronic Hyperandrogenemia in a New Model of
   Postmenopausal Polycystic Ovary Syndrome
SO ENDOCRINOLOGY
LA English
DT Article
ID CARDIOVASCULAR RISK-FACTORS; BLOOD-PRESSURE; METABOLIC SYNDROME;
   OXIDATIVE STRESS; WOMEN; TESTOSTERONE; OBESITY; LIFE
AB Postmenopausal women who have had polycystic ovary syndrome (PCOS) and chronic hyperandrogenemia may be at a greater risk for cardiovascular disease than normoandrogenemic postmenopausal women. The cardiometabolic effect of chronic hyperandrogenemia in women with PCOS after menopause is unclear. The present study was performed to test the hypothesis that chronic hyperandrogenemia in aging female rats would have more deleterious effects on metabolic function, blood pressure, and renal function than in normoandrogenemic age-matched females. Female Sprague Dawley were implanted continuously, beginning at 4-5 weeks, with dihydrotestosterone (postmenopausal hyperandrogenemic female [PMHAF]) or placebo pellets (controls), and were studied at 13 months of age. Plasma DHT was 3-fold higher, and estradiol was 90% lower in PMHAF than controls. Body weights were higher; EchoMRl showed greater fat and lean mass; and computed tomography showed more sc and visceral adiposity in PMHAF, but with similar femur length compared with controls. Insulin resistance was present in PMHAF with higher plasma insulin, normal fasting blood glucose, abnormal oral glucose tolerance test, and higher nonfasting blood glucose. Blood pressure (radiotelemetry) was significantly higher and heart rate was lower, and renal function (glomerular filtration rate) was reduced by 40% in PMHAF. Thus the aging chronically hyperandrogenemic female rat is a new model of postmenopausal PCOS, which exhibits insulin resistance and visceral obesity, hypertension, and impairment in renal function. This new model provides a unique tool to study the deleterious effects of chronic androgen excess in postmenopausal females rats.
C1 [Dalmasso, Carolina; Maranon, Rodrigo; Patil, Chetan; Cardozo, Licy L. Yanes; Reckelhoff, Jane F.] Univ Mississippi, Med Ctr, Dept Physiol & Biophys, Jackson, MS 39216 USA.
   [Maranon, Rodrigo; Bui, Elizabeth; Cardozo, Licy L. Yanes] Univ Mississippi, Med Ctr, Dept Med, Jackson, MS 39216 USA.
   [Moulana, Mohadetheh] Univ Mississippi, Med Ctr, Dept Psychiat, Jackson, MS 39216 USA.
   [Zhang, Howei; Smith, Andrew] Univ Mississippi, Med Ctr, Dept Radiol, Jackson, MS 39216 USA.
   [Dalmasso, Carolina; Maranon, Rodrigo; Patil, Chetan; Cardozo, Licy L. Yanes; Reckelhoff, Jane F.] Univ Mississippi, Med Ctr, Womens Hlth Res Ctr, Jackson, MS 39216 USA.
C3 University of Mississippi; University of Mississippi Medical Center;
   University of Mississippi Medical Center; University of Mississippi;
   University of Mississippi; University of Mississippi Medical Center;
   University of Mississippi Medical Center; University of Mississippi;
   University of Mississippi Medical Center; University of Mississippi
RP Reckelhoff, JF (corresponding author), Univ Mississippi, Med Ctr, 2500 North State St, Jackson, MS 39216 USA.
EM jreckelhoff@umc.edu
RI Smith, Andrew/KQU-0358-2024; Dalmasso, Carolina/LKO-3360-2024; Patil,
   Chetan/ABB-2665-2021
OI Dalmasso, Carolina/0009-0000-0552-2260; Patil,
   Chetan/0000-0002-8483-7179
FU National Institutes of Health National Heart, Lung, and Blood Institute
   [HL66072, HL69194, PO1 HL51971]; American Heart Association [0830239N];
   American Heart Association Southeast Affiliate Postdoctoral Fellowship
   [14POST18640015]; American Heart Association (AHA) [14POST18640015,
   0830239N] Funding Source: American Heart Association (AHA)
FX This work was supported by the National Institutes of Health National
   Heart, Lung, and Blood Institute RO1s HL66072 and HL69194 and PO1
   HL51971 (to J.F.R.), and the American Heart Association Scientific
   Development Grant No. 0830239N (to L.L.Y.), and American Heart
   Association Southeast Affiliate Postdoctoral Fellowship Award
   14POST18640015 (to R.M.).
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NR 27
TC 30
Z9 32
U1 0
U2 12
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0013-7227
EI 1945-7170
J9 ENDOCRINOLOGY
JI Endocrinology
PD JUL
PY 2016
VL 157
IS 7
BP 2920
EP 2927
DI 10.1210/en.2015-1617
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA DQ0GO
UT WOS:000378877200031
PM 27145003
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Lakhter, AJ
   Sims, EK
AF Lakhter, Alexander J.
   Sims, Emily K.
TI Minireview: Emerging Roles for Extracellular Vesicles in Diabetes and
   Related Metabolic Disorders
SO MOLECULAR ENDOCRINOLOGY
LA English
DT Review
ID PLATELET-DERIVED MICROPARTICLES; INSULINOMA-RELEASED EXOSOMES; SOLUBLE
   ADHESION MOLECULES; TOLL-LIKE RECEPTORS; ACTIVATED PLATELETS; HORIZONTAL
   TRANSFER; MESSENGER-RNA; HUMAN SALIVA; MULTIVESICULAR BODIES;
   MEMBRANE-VESICLES
AB Extracellular vesicles (EVs), membrane-contained vesicles released by most cell types, have attracted a large amount of research interest over the past decade. Because of their ability to transfer cargo via regulated processes, causing functional impacts on recipient cells, these structures may play important roles in cell-cell communication and have implications in the physiology of numerous organ systems. In addition, EVs have been described in most human biofluids and have wide potential as relatively noninvasive biomarkers of various pathologic conditions. Specifically, EVs produced by the pancreatic beta-cell have been demonstrated to regulate physiologic and pathologic responses to beta-cell stress, including beta-cell proliferation and apoptosis. beta-Cell EVs are also capable of interacting with immune cells and may contribute to the activation of autoimmune processes that trigger or propagate beta-cell inflammation and destruction during the development of diabetes. EVs from adipose tissue have been shown to contribute to the development of the chronic inflammation and insulin resistance associated with obesity and metabolic syndrome via interactions with other adipose, liver, and muscle cells. Circulating EVs may also serve as biomarkers for metabolic derangements and complications associated with diabetes. This minireview describes the properties of EVs in general, followed by a more focused review of the literature describing EVs affecting the beta-cell, beta-cell autoimmunity, and the development of insulin resistance, which all have the potential to affect development of type 1 or type 2 diabetes.
C1 [Lakhter, Alexander J.; Sims, Emily K.] Indiana Univ, Dept Pediat, Indianapolis, IN 46202 USA.
   [Sims, Emily K.] Indiana Univ, Ctr Diabet & Metab Dis, Indianapolis, IN 46202 USA.
   [Sims, Emily K.] Indiana Univ, Sect Pediat Endocrinol & Diabetol, Indianapolis, IN 46202 USA.
C3 Indiana University System; Indiana University Indianapolis; Indiana
   University System; Indiana University Indianapolis; Indiana University
   System; Indiana University Indianapolis
RP Sims, EK (corresponding author), 705 Riley Hosp Dr,Room 5960, Indianapolis, IN 46202 USA.
EM eksims@iu.edu
FU National Institute of Diabetes and Digestive and Kidney Diseases,
   National Institutes of Health [K08DK103983, P30 DK097512]; Pediatric
   Endocrine Society [T32DK064466]
FX This work was supported by the National Institute of Diabetes and
   Digestive and Kidney Diseases, National Institutes of Health (Grant
   K08DK103983 and Pilot and Feasibility Award P30 DK097512 to E.K.S.) and
   the Pediatric Endocrine Society (Clinical Scholar Award to E.K.S., and
   Grant T32DK064466 to A.J.L.).
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NR 140
TC 47
Z9 52
U1 1
U2 22
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0888-8809
EI 1944-9917
J9 MOL ENDOCRINOL
JI Mol. Endocrinol.
PD NOV
PY 2015
VL 29
IS 11
BP 1535
EP 1548
DI 10.1210/me.2015-1206
PG 14
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA CY6HR
UT WOS:000366510200002
PM 26393296
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Inzucchi, SE
   Zinman, B
   Wanner, C
   Ferrari, R
   Fitchett, D
   Hantel, S
   Espadero, RM
   Woerle, HJ
   Broedl, UC
   Johansen, OE
AF Inzucchi, Silvio E.
   Zinman, Bernard
   Wanner, Christoph
   Ferrari, Roberto
   Fitchett, David
   Hantel, Stefan
   Espadero, Rosa-Maria
   Woerle, Hans-Juergen
   Broedl, Uli C.
   Johansen, Odd Erik
TI SGLT-2 inhibitors and cardiovascular risk: Proposed pathways and review
   of ongoing outcome trials
SO DIABETES & VASCULAR DISEASE RESEARCH
LA English
DT Article
DE Type 2 diabetes; cardiovascular complications; review; macrovascular;
   sodium glucose cotransporter-2 inhibitors
ID TYPE-2 DIABETES-MELLITUS; INADEQUATE GLYCEMIC CONTROL; COTRANSPORTER 2
   INHIBITION; BASE-LINE CHARACTERISTICS; CORONARY-ARTERY-DISEASE;
   URIC-ACID; DOUBLE-BLIND; INSULIN SENSITIVITY; METABOLIC SYNDROME;
   ADIPOSE-TISSUE
AB Given the multi-faceted pathogenesis of atherosclerosis in type 2 diabetes mellitus (T2DM), it is likely that interventions to mitigate this risk must address cardiovascular (CV) risk factors beyond glucose itself. Sodium glucose cotransporter-2 (SGLT-2) inhibitors are newer antihyperglycaemic agents with apparent multiple effects. Inherent in their mode of action to decrease glucose reabsorption by the kidneys by increasing urinary glucose excretion, these agents improve glycaemic control independent of insulin secretion with a low risk of hypoglycaemia. In this review, we outline those CV risk factors that this class appears to influence and provide the design features and trial characteristics of six ongoing outcome trials involving more than 41,000 individuals with T2DM. Those risk factors beyond glucose that can potentially be modulated positively with SGLT-2 inhibitors include blood pressure, weight, visceral adiposity, hyperinsulinaemia, arterial stiffness, albuminuria, circulating uric acid levels and oxidative stress. On the other hand, small increases in low-density lipoprotein (LDL)-cholesterol levels have also been observed for the class, which theoretically might offset some of these benefits. The potential translational impact of these effects is being tested with outcome trials, also reviewed in this article, powered to assess both macrovascular as well as certain microvascular outcomes in T2DM. These are expected to begin to report in late 2015.
C1 [Inzucchi, Silvio E.] Yale Univ, Sch Med, Endocrinol Sect, New Haven, CT USA.
   [Zinman, Bernard] Univ Toronto, Mt Sinai Hosp, Lunenfeld Tanenbaum Res Inst, Toronto, ON M5G 1X5, Canada.
   [Wanner, Christoph] Univ Wurzburg, Div Nephrol, D-97070 Wurzburg, Germany.
   [Ferrari, Roberto] Univ Hosp Ferrara, Dept Cardiol, Ferrara, Italy.
   [Ferrari, Roberto] Univ Hosp Ferrara, LTTA Ctr, Ferrara, Italy.
   [Ferrari, Roberto] ES Hlth Sci Fdn, GVM Care & Res, Maria Cecilia Hosp, Cotignola, Italy.
   [Fitchett, David] Univ Toronto, St Michaels Hosp, Toronto, ON, Canada.
   [Hantel, Stefan] Boehringer Ingelheim Pharma GmbH & Co KG, Biberach, Germany.
   [Espadero, Rosa-Maria] Boehringer Ingelheim Espana SA, Barcelona, Spain.
   [Woerle, Hans-Juergen; Broedl, Uli C.] Boehringer Ingelheim Pharma GmbH & Co KG, Ingelheim, Germany.
   [Johansen, Odd Erik] Boehringer Ingelheim Norway KS, N-1373 Asker, Norway.
C3 Yale University; University of Toronto; Sinai Health System Toronto;
   Lunenfeld Tanenbaum Research Institute; University of Wurzburg;
   University of Ferrara; Arcispedale Sant'Anna; University of Ferrara;
   Arcispedale Sant'Anna; Maria Cecilia Hospital; University of Toronto;
   Saint Michaels Hospital Toronto; Boehringer Ingelheim; Boehringer
   Ingelheim; Boehringer Ingelheim; Boehringer Ingelheim
RP Johansen, OE (corresponding author), Boehringer Ingelheim Norway KS, Drengsrudbekken 8, N-1373 Asker, Norway.
EM Odd_erik.johansen@boehringer-ingelheim.com
RI Inzucchi, Silvio/ABF-4121-2021; Woerle, Hans/ABE-1013-2021; Zinman,
   Bernard/E-7266-2013; FERRARI, ROBERTO/ABD-5169-2020; Wanner,
   Christoph/JOZ-1669-2023
OI Ferrari, Roberto/0000-0003-2046-9175
FU Boehringer Ingelheim
FX No funding was provided for writing this paper. EMPA-REG Outcome (TM) is
   funded by Boehringer Ingelheim.
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NR 75
TC 311
Z9 326
U1 0
U2 46
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1479-1641
EI 1752-8984
J9 DIABETES VASC DIS RE
JI Diabetes Vasc. Dis. Res.
PD MAR
PY 2015
VL 12
IS 2
BP 90
EP 100
DI 10.1177/1479164114559852
PG 11
WC Endocrinology & Metabolism; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Cardiovascular System & Cardiology
GA CB9WN
UT WOS:000349984700003
PM 25589482
OA Green Published, hybrid
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Flores, LE
   Alzugaray, ME
   Cubilla, MA
   Raschia, MA
   Del Zotto, HH
   Román, CL
   Suburo, AM
   Gagliardino, JJ
AF Flores, Luis E.
   Alzugaray, Maria E.
   Cubilla, Marisa A.
   Raschia, Maria A.
   Del Zotto, Hector H.
   Roman, Carolina L.
   Suburo, Angela M.
   Gagliardino, Juan J.
TI Islet Cannabinoid Receptors Cellular Distribution and Biological
   Function
SO PANCREAS
LA English
DT Article
DE cannabinoid receptors; pancreatic islets; metabolic syndrome; beta-cell
   function; dyslipidemia; metabolic homeostasis
ID ADIPOSE-TISSUE; INSULIN-RESISTANCE; OXIDATIVE STRESS; ENDOCANNABINOID
   SYSTEM; GLUCOSE-METABOLISM; CB1 RECEPTOR; FOOD-INTAKE; BETA-CELLS;
   SECRETION; DYSFUNCTION
AB Objectives: This study aimed to determine the cellular distribution of islet cannabinoid receptors (CBs) and their involvement in the development of metabolic and hormonal changes in rats fed a fructose-rich diet (F).
   Methods: In normal rat islets, we determined CBs (immunofluorescence and retrotranscription-polymerase chain reaction) and glucose-stimulated insulin secretion (GSIS) of isolated islets incubated with the CB1 antagonist rimonabant (R) and/or different CBs agonists. In 3-week F-fed rats, we determined the in vivo effect of R on serum glucose, triglyceride, and insulin levels; homeostasis model assessment for insulin resistance, GSIS, and CBs and insulin receptor substrate gene expression levels (real-time polymerase chain reaction).
   Results: Cannabinoid receptors appeared exclusively in islet alpha cells. Whereas different CB agonists enhanced GSIS in normal rat islets, R did not affect it. F rats had higher serum triglyceride and insulin levels and homeostasis model assessment for insulin resistance than control rats; these alterations were prevented by R coadministration. Although R did not correct the increased GSIS observed in F islets, it modulated CBs and insulin receptor substrate gene expression.
   Conclusions: Islet CBs would exert an important modulatory role in metabolic homeostasis. Administration of R and F affected islet CB expression and prevented the development of F-induced metabolic impairment. Selective islet CB1 blockers could be useful to prevent/treat the alterations induced by the intake of unbalanced/unhealthy diets.
C1 [Flores, Luis E.; Alzugaray, Maria E.; Raschia, Maria A.; Del Zotto, Hector H.; Roman, Carolina L.; Gagliardino, Juan J.] UNLP, Fac Ciencias Med, Ctr Colaborador OPS OMS Diabet, CENEXA Ctr Endocrinol Expt & Aplicada UNLP CONICE, RA-1900 La Plata, Buenos Aires, Argentina.
   [Cubilla, Marisa A.; Suburo, Angela M.] Univ Austral, Fac Ciencias Biomed, Buenos Aires, DF, Argentina.
C3 National University of La Plata; Austral University
RP Gagliardino, JJ (corresponding author), UNLP, Fac Ciencias Med, Ctr Colaborador OPS OMS Diabet, CENEXA Ctr Endocrinol Expt & Aplicada UNLP CONICE, RA-1900 La Plata, Buenos Aires, Argentina.
EM cenexa@speedy.com.ar
OI Flores, Luis/0000-0003-1709-8748; Cubilla, Marisa
   Angelica/0000-0002-9862-8933
FU Sanofi-Aventis; National Research Council of Argentina
FX This work was supported by an unrestricted grant provided by
   Sanofi-Aventis and funds provided by the National Research Council of
   Argentina.
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NR 52
TC 12
Z9 12
U1 0
U2 7
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0885-3177
EI 1536-4828
J9 PANCREAS
JI Pancreas
PD OCT
PY 2013
VL 42
IS 7
BP 1085
EP 1092
PG 8
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 300MM
UT WOS:000330468000006
PM 24005231
DA 2025-06-11
ER

PT J
AU Woo, YC
   Xu, AM
   Wang, Y
   Lam, KSL
AF Woo, Y. C.
   Xu, Aimin
   Wang, Yu
   Lam, Karen S. L.
TI Fibroblast Growth Factor 21 as an emerging metabolic regulator: clinical
   perspectives
SO CLINICAL ENDOCRINOLOGY
LA English
DT Review
ID NONALCOHOLIC FATTY LIVER; INCREASES ENERGY-EXPENDITURE; SERUM FGF21
   LEVELS; INSULIN SENSITIVITY; PPAR-ALPHA; PLASMA-CONCENTRATIONS;
   ANOREXIA-NERVOSA; BETA-KLOTHO; OBESITY; FIBROBLAST-GROWTH-FACTOR-21
AB Fibroblast growth factor 21 (FGF21), a metabolic hormone predominantly produced by the liver, is also expressed in adipocytes and the pancreas. It regulates glucose and lipid metabolism through pleiotropic actions in these tissues and the brain. In mice, fasting leads to increased PPAR- mediated expression of FGF21 in the liver where it stimulates gluconeogenesis, fatty acid oxidation, and ketogenesis, as an adaptive response to fasting and starvation. In the fed state, FGF21 acts as an autocrine factor in adipocytes, regulating the activity of PPAR- through a feed-forward loop mechanism. Administration of recombinant FGF21 has been shown to confer multiple metabolic benefits on insulin sensitivity, blood glucose, lipid profile and body weight in obese mice and diabetic monkeys, without mitogenic or other side effects. Such findings highlight the potential role of FGF21 as a therapeutic agent for obesity-related medical conditions. However, in human studies, high circulating FGF21 levels are found in obesity and its related cardiometabolic disorders including the metabolic syndrome, type 2 diabetes, non-alcoholic fatty liver disease and coronary artery disease. These findings may indicate the presence of FGF21 resistance or compensatory responses to the underlying metabolic stress, and imply the need for supraphysiological doses of FGF21 to achieve therapeutic efficacy. On the other hand, serum FGF21 has been implicated as a potential biomarker for the early detection of these cardiometabolic disorders. This review summarizes recent developments in the understanding of FGF21, from physiological and clinical perspectives.
C1 [Woo, Y. C.; Xu, Aimin; Lam, Karen S. L.] Univ Hong Kong, Dept Med, Pokfulam, Hong Kong, Peoples R China.
   [Xu, Aimin; Wang, Yu] Univ Hong Kong, Dept Pharm & Pharmacol, Pokfulam, Hong Kong, Peoples R China.
   [Xu, Aimin; Wang, Yu; Lam, Karen S. L.] Univ Hong Kong, Res Ctr Heart Brain Hormone & Hlth Aging, Pokfulam, Hong Kong, Peoples R China.
C3 University of Hong Kong; University of Hong Kong; University of Hong
   Kong
RP Lam, KSL (corresponding author), Univ Hong Kong, Queen Mary Hosp, Dept Med, 102 Pokfulam Rd, Pokfulam, Hong Kong, Peoples R China.
EM ksllam@hku.hk
RI Wang, Yu/B-4534-2009; /C-4315-2009
OI /0000-0001-5757-541X; wang, yu/0000-0001-8697-2940
FU Hong Kong Research Grant Council [CRF 03/09M]
FX Studies on FGF21 at the University of Hong Kong were supported by CRF
   03/09M from the Hong Kong Research Grant Council.
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NR 56
TC 244
Z9 265
U1 0
U2 83
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0300-0664
EI 1365-2265
J9 CLIN ENDOCRINOL
JI Clin. Endocrinol.
PD APR
PY 2013
VL 78
IS 4
BP 489
EP 496
DI 10.1111/cen.12095
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 107PC
UT WOS:000316229400002
PM 23134073
OA Bronze
DA 2025-06-11
ER

PT J
AU Aravidou, E
   Tsangaris, G
   Samara, A
   Dontas, I
   Botsis, D
   Aravidis, C
   Chrousos, GP
   Malamitsi-Puchner, A
AF Aravidou, Eftychia
   Tsangaris, George
   Samara, Athina
   Dontas, Ismene
   Botsis, Dimitrios
   Aravidis, Christos
   Chrousos, George P.
   Malamitsi-Puchner, Ariadne
TI Aberrant expression of collapsin response mediator proteins-1,-2 and-5
   in the brain of intrauterine growth restricted rats
SO INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
LA English
DT Article
DE Intrauterine growth restriction; Rat model; Brain development; Collapsin
   response mediator protein; Dihydropyrimidinase-related protein;
   Proteomics; Two-dimensional electrophoresis; Western blot analysis
ID DIHYDROPYRIMIDINASE-RELATED PROTEIN-2; ALZHEIMERS-DISEASE BRAIN;
   MOLECULAR CHARACTERIZATION; DEVELOPMENTAL ORIGINS; SEMAPHORIN RECEPTOR;
   DOWN-SYNDROME; RHO-KINASE; FAMILY; IDENTIFICATION; CRMP-2
AB Intrauterine growth restriction (IUGR) has been associated with increased perinatal morbidity, higher incidence of neurodevelopmental defects and increased risk for adult metabolic syndrome manifestations. Altered protein expression profiles associated with IUGR may be informative on the pathological mechanisms of this condition and might reveal potential markers for postnatal complications. We hypothesized that nutrient manipulation of the pregnant rat might influence the expression of important neurodevelopmental proteins in the resultant IUGR offspring. Therefore, we aimed to determine in newborn rat brain tissue the expression of collapsin response mediator proteins (CRMPs)-1, -2 and -5, commonly referred to as dihydropyrimidinase-related proteins (DPYLs) - playing a role in axon guidance, invasive growth and cell migration - and compare it to the corresponding expression in control rats. Two-dimensional electrophoresis and mass spectrometry, as well as Western blot analysis were employed in brain tissue from 24 IUGR newborn rats and 24 controls. With both methods, CRMP-1, CRMP-2 and CRMP-5 were decreased in the brains of the IUGR group as compared to the control group at the time of delivery. In conclusion, IUGR rat offspring are born with a decreased expression of CRMPs, suggesting that these proteins may be implicated in fetal stress-induced programming. (C) 2012 ISDN. Published by Elsevier Ltd. All rights reserved.
C1 [Aravidou, Eftychia; Samara, Athina; Chrousos, George P.] Univ Athens, Aghia Sophia Childrens Hosp, Sch Med, Dept Pediat 1, Athens 11527, Greece.
   [Tsangaris, George] Acad Athens, Biomed Res Fdn, Ctr Basic Res 2, Prote Res Unit, Athens 11527, Greece.
   [Samara, Athina; Chrousos, George P.] Acad Athens, Biomed Res Fdn, Clin Res Ctr, Lab Endocrinol & Metab, Athens 11527, Greece.
   [Dontas, Ismene] Univ Athens, Sch Med, Lab Expt Surg & Surg Res, GR-11527 Athens, Greece.
   [Aravidis, Christos] Univ Athens, Evangelismos Hosp, Sch Med, Crit Care Dept,Cytogenet Unit, Athens 10676, Greece.
   [Malamitsi-Puchner, Ariadne] Univ Athens, Aretaieio Hosp, Sch Med, Dept Obstet & Gynecol 2,Neonatal Div, Athens 11528, Greece.
C3 Athens Medical School; The Aghia Sophia Children's Hospital; National &
   Kapodistrian University of Athens; Academy of Athens; Academy of Athens;
   Athens Medical School; National & Kapodistrian University of Athens;
   National & Kapodistrian University of Athens; Evangelismos Hospital;
   Athens Medical School; Athens Medical School; National & Kapodistrian
   University of Athens
RP Aravidou, E (corresponding author), Univ Athens, Aghia Sophia Childrens Hosp, Sch Med, Dept Pediat 1, Thivon & Papadiamantopoulou Str, Athens 11527, Greece.
EM earavidou@aretaieio.uoa.gr
RI Aravidis, Christos/E-4021-2013; Chrousos, George/G-8702-2011; Tsangaris,
   George/Q-6139-2019; Dontas, Ismene/A-3584-2008
OI Tsangaris, George/0000-0002-5371-4758; Samara,
   Athina/0000-0001-6931-1972; Dontas, Ismene/0000-0002-2440-0119
FU Special Account for Research Grants (SARG) of the National and
   Kapodistrian University of Athens
FX The research was supported by the Special Account for Research Grants
   (SARG) of the National and Kapodistrian University of Athens.
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NR 71
TC 6
Z9 6
U1 0
U2 11
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0736-5748
EI 1873-474X
J9 INT J DEV NEUROSCI
JI Int. J. Dev. Neurosci.
PD FEB
PY 2013
VL 31
IS 1
BP 53
EP 60
DI 10.1016/j.ijdevneu.2012.10.004
PG 8
WC Developmental Biology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Developmental Biology; Neurosciences & Neurology
GA 076ZI
UT WOS:000313997300008
PM 23085080
DA 2025-06-11
ER

PT J
AU Juárez-Rojas, JG
   Medina-Urrutia, AX
   Jorge-Galarza, E
   Caracas-Portilla, NA
   Posadas-Sánchez, R
   Cardoso-Saldaña, GC
   Goycochea-Robles, MV
   Silveira, LH
   Lino-Pérez, L
   Mas-Oliva, J
   Pérez-Méndez, O
   Posadas-Romero, C
AF Juarez-Rojas, J. G.
   Medina-Urrutia, A. X.
   Jorge-Galarza, E.
   Caracas-Portilla, N. A.
   Posadas-Sanchez, R.
   Cardoso-Saldana, G. C.
   Goycochea-Robles, M. V.
   Silveira, L. H.
   Lino-Perez, L.
   Mas-Oliva, J.
   Perez-Mendez, O.
   Posadas-Romero, C.
TI Pioglitazone improves the cardiovascular profile in patients with
   uncomplicated systemic lupus erythematosus: a double-blind randomized
   clinical trial
SO LUPUS
LA English
DT Article
DE atherosclerosis; inflammation; insulin resistance; lipoproteins;
   systemic lupus erythematosus
ID HIGH-DENSITY-LIPOPROTEIN; ACTIVATED RECEPTOR-GAMMA; LOW HDL-CHOLESTEROL;
   GRADIENT GEL-ELECTROPHORESIS; ELEVATED OXIDATIVE STRESS; TYPE-2
   DIABETES-MELLITUS; INSULIN-RESISTANCE; METABOLIC SYNDROME; RISK-FACTORS;
   ANTIOXIDATIVE ACTIVITY
AB Objective: We studied the effect of pioglitazone on insulin levels, inflammation markers, high-density lipoprotein (HDL) composition and subclasses distribution, in young women with uncomplicated systemic lupus erythematosus (SLE).
   Methods: This double-blind trial included 30 premenopausal women (30 +/- 8 years old) with SLE, who were randomized to pioglitazone (30 mg/day) or placebo treatment for 3 months. Plasma and HDL lipids were determined by colorimetric enzymatic assays, insulin by radio-immunometric assay, inflammation by immunonephelometry and HDL size and subclasses distribution by a native 4-30% polyacrylamide gradient gel electrophoresis.
   Results: Compared with placebo, pioglitazone significantly increased HDL-cholesterol plasma levels (14.2%), reduced fasting insulin plasma levels (23.6%) and the homeostasis model assessment-insulin resistance (31.7%). C-reactive protein (70.9%) and serum amyloid A (34.9%) were also significantly reduced with the pioglitazone use, whereas the HDL particle size was increased (8.80nm vs. 8.95 nm; p=0.044) by changes in the distribution of HDL(2b), HDL(3b), and HDL(3c) subclasses. The change in HDL size correlated with a rise in free and cholesterol-ester content in the HDL particles.
   Conclusion: Pioglitazone significantly enhanced insulin sensitivity, reduced inflammation, and modified HDL characteristics, suggesting a potential beneficial effect of this drug in patients with SLE with a risk to develop cardiovascular disease.
C1 [Juarez-Rojas, J. G.; Medina-Urrutia, A. X.; Jorge-Galarza, E.; Caracas-Portilla, N. A.; Posadas-Sanchez, R.; Cardoso-Saldana, G. C.; Posadas-Romero, C.] Natl Inst Cardiol Ignacio Chavez, Dept Endocrinol, Mexico City, DF, Mexico.
   [Juarez-Rojas, J. G.] Univ Nacl Autonoma Mexico, Doctorate Program Biomed Sci, Mexico City, DF, Mexico.
   [Goycochea-Robles, M. V.] Mexican Inst Social Secur, Reg Hosp 1, Clin Epidemiol Res Unit, Mexico City, DF, Mexico.
   [Silveira, L. H.] Natl Inst Cardiol Ignacio Chavez, Dept Rheumatol, Mexico City, DF, Mexico.
   [Lino-Perez, L.] Mexican Gen Hosp, Dept Rheumatol, Mexico City, DF, Mexico.
   [Mas-Oliva, J.] Univ Nacl Autonoma Mexico, Cellular Physiol Inst, Mexico City, DF, Mexico.
   [Perez-Mendez, O.] Natl Inst Cardiol Ignacio Chavez, Dept Mol Biol, Mexico City, DF, Mexico.
C3 National Institute of Cardiology - Mexico; Universidad Nacional Autonoma
   de Mexico; Instituto Mexicano del Seguro Social; National Institute of
   Cardiology - Mexico; Universidad Nacional Autonoma de Mexico; National
   Institute of Cardiology - Mexico
RP Posadas-Romero, C (corresponding author), Juan Badiano 1,Secc 16, Tlalpan 14080, DF, Mexico.
EM cposadasr@yahoo.com
RI Jorge-Galarza, Esteban/AAF-6915-2020; Pérez-Méndez, Oscar/AAJ-8451-2020
OI Juarez-Rojas, Juan Gabriel/0000-0001-8864-2304; Jorge-Galarza,
   Esteban/0000-0002-7748-4678; Cardoso Saldana, Guillermo
   Celestino/0000-0001-9525-1731
FU Biomedical Sciences at National Autonomous University of Mexico;
   National Council for Science and Technology [57997]; National Institute
   of Cardiology "Ignacio Chavez'' [05-487]; Mexican Institute of the
   Social Security [2006-785-031]
FX Juarez-Rojas JG acknowledges support from Doctorate Program of
   Biomedical Sciences at National Autonomous University of Mexico. Authors
   thank Maria del Carmen Gonzalez Salazar and Lubia Velazquez for their
   nutritional assistance for patients, Wendy Angelica Ocampo Arcos for her
   technical assistance in the SDS-polyacrylamide gradient gels
   preparation. All authors are in debt to patients who participated in
   this trial. This work was partially supported by grant 57997 from the
   National Council for Science and Technology, the National Institute of
   Cardiology "Ignacio Chavez'' (protocol number 05-487) and Mexican
   Institute of the Social Security (protocol number 2006-785-031)
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NR 52
TC 21
Z9 24
U1 0
U2 0
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0961-2033
J9 LUPUS
JI Lupus
PD JAN
PY 2012
VL 21
IS 1
BP 27
EP 35
DI 10.1177/0961203311422096
PG 9
WC Rheumatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Rheumatology
GA 861RY
UT WOS:000298038100003
PM 21993383
DA 2025-06-11
ER

PT J
AU Lazzeri, C
   Valente, S
   Tarquini, R
   Chiostri, M
   Picariello, C
   Gensini, GF
AF Lazzeri, Chiara
   Valente, Serafina
   Tarquini, Roberto
   Chiostri, Marco
   Picariello, Claudio
   Gensini, Gian Franco
TI The prognostic role of gamma-glutamyltransferase activity in
   non-diabetic ST-elevation myocardial infarction
SO INTERNAL AND EMERGENCY MEDICINE
LA English
DT Article
DE Gamma-glutamyltransferase; ST elevation myocardial infarction;
   Prognosis; Percutaneous coronary intervention
ID ACUTE CORONARY SYNDROME; CARDIOVASCULAR-DISEASE; INSULIN-RESISTANCE;
   GLUCOSE DYSMETABOLISM; METABOLIC SYNDROME; OXIDATIVE STRESS; STEMI
   PATIENTS; HEART-DISEASE; URIC-ACID; RISK
AB In patients with acute coronary syndrome, gamma-glutamyltransferase activity (GGT) proved to be an independent predictor of the development of major adverse cardiac events at early and long terms. No data are available on GGT in ST-elevation myocardial infarction (STEMI). We assessed, in 337 consecutive STEMI patients without previously known diabetes submitted to mechanical revascularization, the prognostic role of GGT for in-Intensive Cardiac Care Unit mortality, together with the relation(s) between GGT and acute glucose dysmetabolism (admission glycemia, peak glycemia, insulin resistance as indicated by the Homeostatic Model Assessment HOMA index). At logistic regression analysis, GGT was an independent predictor for in-ICU mortality (OR 1.01 (95% CI 1.003-1.013) p = 0.002), when adjusted for BMI and for major bleedings [(OR 1.005 (95% CI 1.001-1.009) p = 0.029]. At linear regression analyses, GGT was significantly correlated with admission glycemia (r = 0.172; p = 0.002), uric acid (r = 0.146; p = 0.011), insulin (r = 0.171; p = 0.002) and age (r = -0.129; p = 0.020). We document that in STEMI patients without previously known diabetes submitted to mechanical revascularization, GGT values are an independent predictor of early mortality. The significant correlation between GGT and acute glucose dysmetabolism (as indicated by admission glycemia and insulin-resistance) can account, at least in part, for the prognostic role of GGT.
C1 [Lazzeri, Chiara; Valente, Serafina; Chiostri, Marco; Picariello, Claudio; Gensini, Gian Franco] Univ Florence, Intens Cardiac Coronary Unit, Heart & Vessel Dept, Azienda Osped Univ Careggi, I-50134 Florence, Italy.
   [Tarquini, Roberto] Univ Florence, Dept Internal Med, Azienda Osped Univ Careggi, I-50134 Florence, Italy.
C3 University of Florence; Azienda Ospedaliero Universitaria Careggi;
   University of Florence; Azienda Ospedaliero Universitaria Careggi
RP Lazzeri, C (corresponding author), Univ Florence, Intens Cardiac Coronary Unit, Heart & Vessel Dept, Azienda Osped Univ Careggi, VialeMorgagni 85, I-50134 Florence, Italy.
EM lazzeric@libero.it
RI Picariello, Claudio/AAM-5175-2020
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NR 40
TC 21
Z9 22
U1 0
U2 1
PU SPRINGER-VERLAG ITALIA SRL
PI MILAN
PA VIA DECEMBRIO, 28, MILAN, 20137, ITALY
SN 1828-0447
EI 1970-9366
J9 INTERN EMERG MED
JI Intern. Emerg. Med.
PD JUN
PY 2011
VL 6
IS 3
BP 213
EP 219
DI 10.1007/s11739-010-0464-8
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 766QG
UT WOS:000290800700003
PM 20878500
DA 2025-06-11
ER

PT J
AU Camins, A
   Sureda, FX
   Junyent, F
   Verdaguer, E
   Folch, J
   Pelegri, C
   Vilaplana, J
   Beas-Zarate, C
   Pallàs, M
AF Camins, Antoni
   Sureda, Francesc X.
   Junyent, Felix
   Verdaguer, Ester
   Folch, Jaume
   Pelegri, Carme
   Vilaplana, Jordi
   Beas-Zarate, Carlos
   Pallas, Merce
TI Sirtuin activators: Designing molecules to extend life span
SO BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
LA English
DT Review
DE Sirtuins; Resveratrol; Neurodegenerative diseases; Diabetes; Sirtuin
   activators
ID PROTECTS DOPAMINERGIC-NEURONS; DECREASES ADIPOCYTE FORMATION; VS.
   INACTIVE CHROMATIN; SOMATIC H1 SUBTYPES; OXIDATIVE STRESS; RED WINE;
   RESVERATROL PROTECTS; CALORIE RESTRICTION; ALZHEIMERS-DISEASE;
   OSTEOBLAST DIFFERENTIATION
AB Resveratrol (RESV) exerts important pharmacological effects on human health: in addition to its beneficial effects on type 2 diabetes and cardiovascular diseases, it also modulates neuronal energy homeostasis and shows antiaging properties. Although it clearly has free radical scavenger properties, the mechanisms involved in these beneficial effects are not fully understood. In this regard, one area of major interest concerns the effects of RESV on the activity of sirtuin 1 (SIRT1), an NAD(+)-dependent histone deacetylase that has been implicated in aging. Indeed, the role of SIRT1 is currently the subject of intense research due to the antiaging properties of RESV, which increases life span in various organisms ranging from yeast to rodents. In addition, when RESV is administered in experimental animal models of neurological disorders, it has similar beneficial effects to caloric restriction. SIRT1 activation could thus constitute a potential strategic target in neurodegenerative diseases and in disorders involving disturbances in glucose homeostasis, as well as in dyslipidaemias or cardiovascular diseases. Therefore, small SIRT1 activators such as SRT501, SRT2104, and SRT2379, which are currently undergoing clinical trials, could be potential drugs for the treatment of type 2 diabetes, obesity, and metabolic syndrome, among other disorders. This review summarises current knowledge about the biological functions of SIRT1 in aging and aging-associated diseases and discusses its potential as a pharmacological target. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Camins, Antoni; Junyent, Felix; Verdaguer, Ester; Pallas, Merce] Univ Barcelona, Fac Farm,Nucli Univ Pedralbes, Inst Biomed IBUB,Unitat Farmacol & Farmacognosia, Ctr Invest Biomed Red Enfermedades Neurodegenerat, E-08028 Barcelona, Spain.
   [Sureda, Francesc X.] Univ Rovira & Virgili, Fac Med & Ciencies Salut, Unitat Farmacol, Ctr Invest Biomed Red Enfermedades Neurodegenerat, Tarragona 43201, Spain.
   [Junyent, Felix; Folch, Jaume] Univ Rovira & Virgili, Fac Med & Ciencies Salut, Unitat Bioquim, Ctr Invest Biomed Red Enfermedades Neurodegenerat, Tarragona 43201, Spain.
   [Beas-Zarate, Carlos] Univ Guadalajara, Div Neurociencias, Ctr Invest Biomed Occidente, Dept Biol Celular & Mol,CUCBA,IMSS, Guadalajara 44340, Jalisco, Mexico.
   [Pelegri, Carme; Vilaplana, Jordi] Univ Barcelona, Fac Farm, Dept Fisiol, Ctr Invest Biomed Red Enfermedades Neurodegenerat, E-08028 Barcelona, Spain.
C3 University of Barcelona; CIBERNED; Universitat Rovira i Virgili;
   CIBERNED; CIBERNED; Universitat Rovira i Virgili; Universidad de
   Guadalajara; CIBERNED; University of Barcelona
RP Camins, A (corresponding author), Univ Barcelona, Fac Farm,Nucli Univ Pedralbes, Inst Biomed IBUB,Unitat Farmacol & Farmacognosia, Ctr Invest Biomed Red Enfermedades Neurodegenerat, E-08028 Barcelona, Spain.
EM camins@ub.edu
RI Camins, Antonio/J-5126-2019; Folch, Jaume/L-3366-2014; Pallas,
   Merce/H-3129-2016; Pelegri, Carme/V-2742-2017; Sureda, Francesc
   X./K-8046-2014; Vilaplana, Jordi/U-7514-2017; Verdaguer,
   Ester/M-1269-2014
OI Folch, Jaume/0000-0002-5051-8858; Pallas, Merce/0000-0003-3095-4254;
   Pelegri, Carme/0000-0002-7734-1546; Sureda, Francesc
   X./0000-0002-7968-3929; Vilaplana, Jordi/0000-0003-2113-238X; Verdaguer,
   Ester/0000-0002-2563-526X; Camins, Antoni/0000-0002-1229-5956; Junyent,
   Felix/0000-0003-0045-2253
FU Spanish Ministry of Education and Science [SAF-2009-13093]; Fondo de
   Investigacion Sanitaria; Instituto de Salud Carlos III [PI080400,
   PS09/01789]; Catalan Government (Generalitat de Catalunya)
   [2009/SGR00853]; Fundacio la Marato TV3 [063230]; Generalitat
FX This study was supported by grants from the Spanish Ministry of
   Education and Science SAF-2009-13093, the Fondo de Investigacion
   Sanitaria, and the Instituto de Salud Carlos III (PI080400 and
   PS09/01789). We thank the Catalan Government (Generalitat de Catalunya)
   for supporting the research groups (2009/SGR00853) and Fundacio la
   Marato TV3 (063230). 610RT0405 was from Programa Iberoamericano de
   Ciencia y Tecnologia para el Desarrollo (CYTED). Ester Verdaguer holds a
   "Beatriu de Pinos" postdoctoral contract, awarded by the Generalitat. We
   thank the University of Barcelona Language Services for revising the
   manuscript.
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NR 103
TC 66
Z9 75
U1 0
U2 25
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1874-9399
EI 1876-4320
J9 BBA-GENE REGUL MECH
JI Biochim. Biophys. Acta-Gene Regul. Mech.
PD OCT-DEC
PY 2010
VL 1799
IS 10-12
SI SI
BP 740
EP 749
DI 10.1016/j.bbagrm.2010.06.005
PG 10
WC Biochemistry & Molecular Biology; Biophysics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics
GA 701KJ
UT WOS:000285816500008
PM 20601277
DA 2025-06-11
ER

PT J
AU Ladage, D
   Reidenbach, C
   Rieckeheer, E
   Graf, C
   Schwinger, RHG
   Brixius, K
AF Ladage, Dennis
   Reidenbach, Christian
   Rieckeheer, Eva
   Graf, Christine
   Schwinger, Robert H. G.
   Brixius, Klara
TI Nebivolol Lowers Blood Pressure and Increases Weight Loss in Patients
   With Hypertension and Diabetes in Regard to Age
SO JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
LA English
DT Article
DE nebivolol; hypertension; diabetes; age; gender
ID NITRIC-OXIDE SYNTHASE; INSULIN-RESISTANCE; OXIDATIVE STRESS;
   DYSFUNCTION; ACTIVATION; CARVEDILOL; METOPROLOL; ESTROGEN
AB Background: In patients with diabetes mellitus type 2 and arterial hypertension, the control of systolic and diastolic blood pressure is essential to reduce the risk of adverse events. The present study investigates the effect of treatment with the third-generation beta-blocker nebivolol, in female and male patients of different ages.
   Methods: Five thousand thirty-one male and female patients with mild to moderate hypertension and type 2 diabetes were treated with a daily dose of 5-mg nebivolol for 12 weeks. Before and after therapy, each patient's blood pressure, heart rate, and body weight were measured and blood samples were obtained to study metabolic parameters.
   Results: Nebivolol reduced systolic blood pressure, in both sexes, to a similar extent. In regard to age, the most significant reduction in blood pressure over the 12-week treatment period was observed in the group of patients below the age of 40. With advancing age, there was a decline in the reduction of systolic blood pressure induced by nebivolol. This effect was more evident among the decennial age groups in respect to diastolic blood pressure. In addition, we found weight reduction to be age dependent. Body weight was significantly more reduced in men compared with women.
   Conclusions: Nebivolol is effective in treating patients with diabetes suffering from high blood pressure and metabolic syndrome. The significantly decreased effect on blood pressure found in elderly patients may be attributed to increased endothelial dysfunction with advancing age.
C1 [Ladage, Dennis; Reidenbach, Christian; Rieckeheer, Eva; Graf, Christine; Brixius, Klara] German Sport Univ Cologne, Dept Mol & Cellular Sport Med, Inst Cardiol & Sport Med, D-50933 Cologne, Germany.
   [Ladage, Dennis; Reidenbach, Christian] Univ Cologne, Lab Muscle Res & Mol Cardiol, Dept Internal Med 3, Cologne, Germany.
   [Schwinger, Robert H. G.] Clin Internal Med & Cardiol 2, Weiden, Germany.
C3 German Sport University Cologne; University of Cologne
RP Brixius, K (corresponding author), German Sport Univ Cologne, Dept Mol & Cellular Sport Med, Inst Cardiol & Sport Med, Carl Diem Weg 6, D-50933 Cologne, Germany.
EM brixius@dshs-koeln.de
RI Graf, Christine/K-7411-2013
OI Ladage, Dennis/0000-0002-4512-0917
FU Berlin Chemie
FX We report financial support by a research grant from Berlin Chemie for
   this study.
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NR 28
TC 18
Z9 18
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0160-2446
EI 1533-4023
J9 J CARDIOVASC PHARM
JI J. Cardiovasc. Pharmacol.
PD SEP
PY 2010
VL 56
IS 3
BP 275
EP 281
DI 10.1097/FJC.0b013e3181eb4ff2
PG 7
WC Cardiac & Cardiovascular Systems; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Pharmacology & Pharmacy
GA 650JW
UT WOS:000281846200010
PM 20571428
DA 2025-06-11
ER

PT J
AU Supriya, R
   Li, FF
   Yang, YD
   Liang, W
   Baker, JS
AF Supriya, Rashmi
   Li, Fei-Fei
   Yang, Yi-De
   Liang, Wei
   Baker, Julien S.
TI Association between Metabolic Syndrome Components and Cardiac Autonomic
   Modulation among Children and Adolescents: A Systematic Review and
   Meta-Analysis
SO BIOLOGY-BASEL
LA English
DT Review
DE metabolic syndrome; cardiac autonomic modulation; heart rate
   variability; children; adolescents; pre-pubertal adolescents;
   meta-analysis; systematic review
ID HEART-RATE-VARIABILITY; CARDIOVASCULAR RISK-FACTORS; BLOOD-PRESSURE;
   SHORT-TERM; SYMPATHOVAGAL BALANCE; WAIST CIRCUMFERENCE;
   DIABETES-MELLITUS; CHRONIC STRESS; OBESITY; LIPIDS
AB Simple Summary The clustering of metabolic syndrome (MetS) risk factors is becoming more prevalent in young people (up to the age of 19 years) leading to the development of type 2 diabetes (T2D) and cardiovascular diseases in early adulthood. The impact of MetS risk factors on cardiac autonomic modulation (CAM) or vice versa have been noted to track from childhood to pre-adolescence and adolescence. Understating associations in this age group may help improve the clinical outcomes of the MetS, even when MetS symptoms are not visible. Potential damage from each individual MetS component and the ability to predict early cardiac damage or upcoming cardiovascular events is very important. Therefore, the present systematic review and meta-analysis investigated the associations between CAM and MetS risk factors individually to verify which MetS risk components were significantly correlated with which heart rate variability (HRV) indices before or at the onset of the MetS among young people. The purpose of this review was to outline the importance of potentially screening HRV indices in young people even with only one MetS risk factor, as a pre-indicator for early cardiovascular risk stratification. Cross-sectional studies that examined the relationship of MetS risk factors with HRV indices were searched using four databases including PubMed, the Cochrane clinical trials library, Medline and the Web of Science. Correlation coefficients with 95% confidence intervals (95% CI), and random effects meta-analyses of the association between MetS risk factors with HRV indices were performed. Our results propose that lipid profiles including high density lipoprotein (HDL) and triglycerides (TGs), waist circumference (WC) and blood pressure (BP) are associated with CAM in young people up to the age of 19 years. The use of HRV indices to predict future MetS risk, and relationships with individual risk factors including HDL, BP, WC and TGs, were established. Furthermore, arterial pressure, respiration, stress and physical activity must be taken into consideration for future studies along with CAM related to young people (up to the age of 19 years), and it is recommended to explore further the associations reported here, as CAM is not the only determinant of neurovisceral regulation. Background: the clustering of metabolic syndrome (MetS) risk factors is becoming more prevalent in children, leading to the development of type 2 diabetes (T2D) and cardiovascular diseases in early adulthood. The impact of MetS risk factors on cardiac autonomic modulation (CAM) or vice versa has been noted to track from childhood to pre-adolescence and adolescence. Understating associations in this age group may help to improve the clinical outcomes of the MetS, even when MetS symptoms are not visible. Potential damage from each individual MetS component and the ability to predict early cardiac damage or upcoming cardiovascular events is very important. Therefore, the present systematic review and meta-analysis investigated the associations between CAM and MetS risk factors individually to verify which of the MetS risk components were significantly correlated with heart rate variability (HRV) indices before or at the onset of the MetS among young people. The purpose of this review was to outline the importance of potentially screening HRV indices in young people even with only one MetS risk factor, as a pre-indicator for early cardiovascular risk stratification.
   Methods: cross-sectional studies that examined the relationship of MetS risk factors with HRV indices were searched using four databases including PubMed, the Cochrane clinical trials library, Medline and the Web of Science. Correlation coefficients with 95% confidence intervals (95% CI), and random effects meta-analyses of the association between MetS risk factors with HRV indices were performed. Results: out of 14 cross-sectional studies and one case-control study, 8 studies (10 data sets) provided association data for the meta-analysis. Our results indicated significant positive correlations for systolic blood pressure (SBP) (correlation coefficient 0.13 (95%CI: 0.06; 0.19), I-2 = 47.26%) and diastolic blood pressure (DBP) (correlation coefficient 0.09 (95%CI: -0.01; 0.18), I-2 = 0%) with a Low Frequency/High Frequency ratio (LF/HF). Significant negative correlations for waist circumference (WC) (correlation coefficient -0.12 (95%CI: -0.19; -0.04), I-2 = 51.50%), Triglycerides (TGs) (correlation coefficient -0.09 (95%CI: -0.15; -0.02), I-2 = 0%) and >= 2 MetS risk factors (correlation coefficient -0.10 (95%CI: -0.16; -0.03), I-2 = 0%); with high frequency (HF) were revealed. Significant positive correlations for high density lipoprotein (HDL) (correlation coefficient 0.08 (95%CI: 0.05; 0.11), I-2 = 0%) and significant negative correlations of >= 2 MetS risk (correlation coefficient -0.04 (95%CI: -0.12; 0.03), I-2 = 0.0%) with low frequency (LF) were revealed. Significant negative correlations for TGs (correlation coefficient -0.09 (95%CI: -0.23; 0.05), I-2 = 2.01%) with a mean square root of the sum of differences between mean time between two successive intervals (rMSSD) and significant positive correlation of HDL (correlation coefficient 0.09 (95%CI: -0.01; 0.19), I-2 = 0.33%) with standard deviation of the time between two successive intervals (SDNN) were also revealed. An Egger's test indicated that there was no obvious publication bias for any of the above relationships except for TGs and rMSSD. The significance level stipulated for the meta-analysis was p < 0.05. Conclusions: lipid profiles (HDL and TGs), WC and BP were associated with CAM in young people up to the age of 19 years. The use of HRV indices to predict future MetS risk, and relationships with individual risk factors including HDL, BP, WC and TGs, were established. Future studies related to young people (up to the age of 19 years) are recommended to explore the associations reported here further.
C1 [Supriya, Rashmi; Li, Fei-Fei; Liang, Wei; Baker, Julien S.] Hong Kong Baptist Univ, Ctr Hlth & Exercise Sci Res, Dept Sport Phys Educ & Hlth, Kowloon Tong, Hong Kong 999077, Peoples R China.
   [Yang, Yi-De] Hunan Normal Univ, Sch Med, Changsha 410081, Peoples R China.
C3 Hong Kong Baptist University; Hunan Normal University
RP Supriya, R; Baker, JS (corresponding author), Hong Kong Baptist Univ, Ctr Hlth & Exercise Sci Res, Dept Sport Phys Educ & Hlth, Kowloon Tong, Hong Kong 999077, Peoples R China.
EM rashmisupriya@hkbu.edu.hk; lifeifei@hkbu.edu.hk; yangyide2007@126.com;
   wliang1020@hkbu.edu.hk; jsbaker@hkbu.edu.hk
RI Li, Feifei/JTT-8011-2023; Liang, Wei/JYO-8476-2024
OI Liang, Wei/0000-0002-8120-7905; Baker, Julien/0000-0002-9093-7897; Yang,
   Yide/0000-0003-3297-1306; Supriya, Rashmi/0000-0003-2995-1910
FU Hong Kong Research Grants Council Postdoctoral Fellowship Scheme
   [PDFS2021-2H01]; National Science Foundation of China [81903336]; Human
   Provincial Natural Science Foundation of China [2019JJ50376]; Scientific
   Research Project of Human Health Committee [202112031516]
FX This study was supported by the Hong Kong Research Grants Council
   Postdoctoral Fellowship Scheme (PDFS2021-2H01), National Science
   Foundation of China (Grant no. 81903336), Human Provincial Natural
   Science Foundation of China (Grant no. 2019JJ50376) and the Scientific
   Research Project of Human Health Committee (Grant no. 202112031516).
   This research received no external funding.
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NR 72
TC 6
Z9 6
U1 1
U2 11
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2079-7737
J9 BIOLOGY-BASEL
JI Biology-Basel
PD AUG
PY 2021
VL 10
IS 8
AR 699
DI 10.3390/biology10080699
PG 19
WC Biology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Life Sciences & Biomedicine - Other Topics
GA UG0EJ
UT WOS:000688936700001
PM 34439932
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Amlashi, MA
   Payahoo, A
   Maskouni, SJ
   Dehghani, E
   Talandashti, MK
   Ghelichi, Y
   Nikoumanesh, M
   Rezvani, S
   Shahinfar, H
   Shidfar, F
AF Amlashi, Manoochehr Amin
   Payahoo, Atefeh
   Maskouni, Saber Jafari
   Dehghani, Elaheh
   Talandashti, Mahtab Karami
   Ghelichi, Yeganeh
   Nikoumanesh, Mahya
   Rezvani, Soroush
   Shahinfar, Hossein
   Shidfar, Farzad
TI Dose-dependent effects of omega-3 polyunsaturated fatty acids on
   C-reactive protein concentrations in cardiometabolic disorders: a
   dose-response meta-analysis of randomized clinical trials
SO INFLAMMOPHARMACOLOGY
LA English
DT Review; Early Access
DE Omega 3; EPA; DHA; C-Reactive protein (CRP)
ID CARDIOVASCULAR-DISEASE RISK; FISH-OIL; OMEGA-3-FATTY-ACID
   SUPPLEMENTATION; EICOSAPENTAENOIC ACID; MYOCARDIAL-INFARCTION;
   DOCOSAHEXAENOIC ACID; INSULIN SENSITIVITY; OXIDATIVE STRESS; DIETARY
   FISH; SERUM-LIPIDS
AB BackgroundBased on current knowledge, omega-3 fatty acids help to reduce the concentration of C-reactive protein (CRP). However, the dose-response effect and the strength of this effect are not entirely clear.MethodsWe systematically searched and screened databases to include eligible studies. This study incorporates a random effect, as well as dose-response meta-analyses using a restricted cubic spline model.ResultsForty randomized clinical trials were analyzed. Results demonstrated significant non-linear dose-response efficacy in the reduction of CRP concentration in patients with cardiovascular disease, metabolic syndrome, and hypertension up to 1200 mg/day of EPA and DHA. In addition, there was a linear decrease in CRP concentration in the dyslipidemia population. The meta-analysis results did not show any significant reduction of CRP in overweight and obese participants, and the dose-response analysis failed to show any apparent reduction. In type 2 diabetes, pooling the results revealed a significant reduction in CRP; however, the combination of EPA and DHA failed to show significant dose-response efficacy in changing CRP concentration.Conclusion1200 mg/day of EPA and DHA may help to reduce CRP concentration in patients with cardiometabolic disorders. This reduction is clinically significant, and thus intervention with omega-3 fatty acids should be considered for this population.
C1 [Amlashi, Manoochehr Amin; Talandashti, Mahtab Karami; Rezvani, Soroush; Shidfar, Farzad] Iran Univ Med Sci, Sch Publ Hlth, Dept Nutr, Tehran, Iran.
   [Amlashi, Manoochehr Amin; Shidfar, Farzad] Iran Univ Med Sci, Nutr Sci Res Ctr, Tehran, Iran.
   [Payahoo, Atefeh] Islamic Azad Univ, Fac Med, Marand Branch, Marand, Iran.
   [Maskouni, Saber Jafari] Jiroft Univ Med Sci, Sch Publ Hlth, Dept Nutr, Jiroft, Iran.
   [Dehghani, Elaheh] Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Clin Nutr, Tehran, Iran.
   [Dehghani, Elaheh] Univ Tehran Med Sci, Neurosci Inst, Sports Med Res Ctr, Tehran, Iran.
   [Dehghani, Elaheh] Ahvaz Jundishapur Univ Med Sci, Clin Sci Res Inst, Nutr & Metab Dis Res Ctr, Ahvaz, Iran.
   [Ghelichi, Yeganeh; Nikoumanesh, Mahya] Varastegan Inst Med Sci, Student Res Comm, Mashhad, Iran.
   [Shahinfar, Hossein] Lorestan Univ Med Sci, Nutr Hlth Res Ctr, Khorramabad, Iran.
C3 Iran University of Medical Sciences; Iran University of Medical
   Sciences; Islamic Azad University; Tehran University of Medical
   Sciences; Tehran University of Medical Sciences; Ahvaz Jundishapur
   University of Medical Sciences (AJUMS); Lorestan University of Medical
   Sciences
RP Shidfar, F (corresponding author), Iran Univ Med Sci, Sch Publ Hlth, Dept Nutr, Tehran, Iran.; Shidfar, F (corresponding author), Iran Univ Med Sci, Nutr Sci Res Ctr, Tehran, Iran.
EM shidfar.f@iums.ac.ir
RI Shidfar, Farzad/H-6651-2018; Shahinfar, Hossein/ABF-9212-2020
OI shidfar, Farzad/0000-0002-6531-9253
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NR 85
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER BASEL AG
PI BASEL
PA PICASSOPLATZ 4, BASEL, 4052, SWITZERLAND
SN 0925-4692
EI 1568-5608
J9 INFLAMMOPHARMACOLOGY
JI Inflammopharmacology
PD 2025 APR 22
PY 2025
DI 10.1007/s10787-025-01744-8
EA APR 2025
PG 15
WC Immunology; Pharmacology & Pharmacy; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Pharmacology & Pharmacy; Toxicology
GA 1RW3F
UT WOS:001472176800001
PM 40263171
DA 2025-06-11
ER

PT J
AU Baek, SU
   Yoon, JH
AF Baek, Seong-Uk
   Yoon, Jin-Ha
TI Systemic Inflammation Across Metabolic Obesity Phenotypes: A
   Cross-Sectional Study of Korean Adults Using High-Sensitivity C-Reactive
   Protein as a Biomarker
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE adiposity; body weight; metabolic syndrome; oxidative stress
ID SEX-DIFFERENCES; ALL-CAUSE; ASSOCIATION; HEALTHY; LEPTIN; GUIDELINES;
   OVERWEIGHT; MORTALITY
AB Chronic systemic inflammation is a hallmark of obesity. This cross-sectional study aimed to investigate the association between metabolic obesity phenotypes and inflammatory markers in Korean adults (N = 21,112; mean age: 50.9 +/- 16.6). Metabolic obesity phenotypes were categorized into metabolically healthy non-obesity (MHNO), metabolically unhealthy non-obesity (MUNO), metabolically healthy obesity (MHO), and metabolically unhealthy obesity (MUO) based on body mass index and the presence of any metabolic abnormalities. High-sensitivity C-reactive protein (hs-CRP) levels were measured. Multiple linear regression was used to determine the association between obesity phenotypes and hs-CRP levels. In the male sample, compared to the MHNO type, the MUNO, MHO, and MUO types were associated with a 22.3% (95% confidence interval; CI: 14.7-30.3%), 15.8% (95% CI: 2.6-30.7%), and 12.5% (95% CI: 3.0-22.9%) increase in the hs-CRP levels, respectively. The association between metabolic obesity types and hs-CRP levels was stronger among the female sample; compared to the MHNO type, the MUNO, MHO, and MUO types were associated with a 30.2% (95% CI: 22.8-38.2%), 16.0% (95% CI: 6.5-26.4%), and 22.8% (95% CI: 13.6-32.8%) increase in the hs-CRP levels, respectively. Our findings indicate a varying profile of systemic inflammation across different metabolic obesity phenotypes.
C1 [Baek, Seong-Uk] Yonsei Univ, Coll Med, Grad Sch, Seoul 03722, South Korea.
   [Yoon, Jin-Ha] Yonsei Univ, Coll Med, Dept Prevent Med, Seoul 03722, South Korea.
C3 Yonsei University; Yonsei University Health System; Yonsei University;
   Yonsei University Health System
RP Yoon, JH (corresponding author), Yonsei Univ, Coll Med, Dept Prevent Med, Seoul 03722, South Korea.
EM flyinyou@yuhs.ac
OI Yoon, Jin-Ha/0000-0003-4198-2955; Baek, Seong-Uk/0000-0002-0882-8326
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NR 68
TC 0
Z9 0
U1 1
U2 1
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD NOV
PY 2024
VL 25
IS 21
AR 11540
DI 10.3390/ijms252111540
PG 13
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA L5V3L
UT WOS:001351389700001
PM 39519093
OA gold
DA 2025-06-11
ER

PT J
AU Papagianni, O
   Loukas, T
   Magkoutis, A
   Kagoudi, M
   Skalkos, D
   Kafetzopoulos, D
   Dimou, C
   Karantonis, HC
   Koutelidakis, AE
AF Papagianni, Olga
   Loukas, Thomas
   Magkoutis, Athanasios
   Kagoudi, Maria
   Skalkos, Dimitrios
   Kafetzopoulos, Dimitrios
   Dimou, Charalampia
   Karantonis, Haralabos C.
   Koutelidakis, Antonios E.
TI Postprandial Responses of Serum Cholesterol, Glucose and Plasma
   Antioxidant Activity, after Intake of an Innovative High Fat
   Mayonnaise-Based Appetizer, Enhanced with Olive Paste, in Healthy
   Volunteers
SO LIFE-BASEL
LA English
DT Article
DE Mediterranean diet; postprandial responses; postprandial bioactivity;
   bioactive components; olive paste functionality; metabolic biomarkers
ID OIL
AB Several Mediterranean functional foods and their process by-products may exert a beneficial role on hyperlipidemia, hyperglycemia, and oxidative stress modulation, providing bioactive compounds with functional properties, contributing to possible chronic disease prevention (cardiovascular disease, metabolic syndrome, obesity, diabetes mellitus, etc.). The purpose of the present interventional study was to investigate the postprandial responses of metabolic biomarkers, after the intake of an innovative mayonnaise-based appetizer, enhanced with olive paste, in healthy volunteers. In this cross-over design, randomized and single-blind, interventional-clinical trial, 10 healthy volunteers, aged 20-30 years old, after splitting into the control group and the Mediterranean group, consumed a pasta meal rich in fat and carbohydrates (150 g), containing a mayonnaise-based appetizer or the same appetizer, enhanced with 9% olive paste. After a 1-week washout period, the subjects consumed the meals in reverse. Differences between groups on postprandial responses of total plasma antioxidant capacity according to the FRAP method, serum total cholesterol, glucose, and uric acid levels, were determined before, 30 min, 1.5 h, and 3 h after consumption. The results showed that, in comparison to the control group, consumption of the enhanced appetizer resulted in a significantly decreased total serum cholesterol and glucose levels, and also led to a significant increase in plasma total antioxidant activity, 3 h after consumption (p < 0.05). Further investigation with large prospective studies is needed to validate the current results.
C1 [Papagianni, Olga; Kagoudi, Maria; Dimou, Charalampia; Koutelidakis, Antonios E.] Univ Aegean, Dept Food Sci & Nutr, Unit Human Nutr, Lab Nutr & Publ Hlth, Myrina 81400, Greece.
   [Loukas, Thomas; Magkoutis, Athanasios] Outpatient Clin, Myrina 81400, Greece.
   [Skalkos, Dimitrios] Univ Ioannina, Dept Chem, Lab Food Chem, Ioannina 45110, Greece.
   [Kafetzopoulos, Dimitrios] Univ Macedonia, Dept Business Adm, Thessaloniki 54636, Greece.
   [Karantonis, Haralabos C.] Univ Aegean, Dept Food Sci & Nutr, Lab Food Chem Biochem & Technol, Myrina 81400, Greece.
C3 University of Ioannina; University of Macedonia
RP Koutelidakis, AE (corresponding author), Univ Aegean, Dept Food Sci & Nutr, Unit Human Nutr, Lab Nutr & Publ Hlth, Myrina 81400, Greece.
EM akoutel@aegean.gr
RI Papagianni, Olga/KIE-3020-2024; SKALKOS, DIMITRIS/AIB-6019-2022
OI KOUTELIDAKIS, ANTONIOS/0000-0001-5137-0499; Magkoutis,
   Athanasios/0000-0002-8453-0716; KARANTONIS,
   HARALABOS/0000-0003-1134-7811; Papagianni, Olga/0000-0003-0026-0630;
   Kafetzopoulos, Dimitrios/0000-0002-0081-9409; SKALKOS,
   DIMTRIS/0000-0002-7771-2845
FU research program "Research & Development (R&D) of innovative, functional
   dishes (FUNDISH)", ERDF-West Macedonia regional funded program 2014-2020
   of the "BIOFLO" food industry [WMP1-0014380]
FX This research was funded by the research program "Research & Development
   (R&D) of innovative, functional dishes (FUNDISH)", ERDF-West Macedonia
   regional funded program 2014-2020 (WMP1-0014380) of the "BIOFLO" food
   industry (Bioflo.gr).
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NR 18
TC 2
Z9 2
U1 0
U2 1
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2075-1729
J9 LIFE-BASEL
JI Life-Basel
PD SEP
PY 2022
VL 12
IS 9
AR 1385
DI 10.3390/life12091385
PG 9
WC Biology; Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics; Microbiology
GA 4V8CU
UT WOS:000859700900001
PM 36143421
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Krikorian, R
   Skelton, MR
   Summer, SS
   Shidler, MD
   Sullivan, PG
AF Krikorian, Robert
   Skelton, Matthew R.
   Summer, Suzanne S.
   Shidler, Marcelle D.
   Sullivan, Patrick G.
TI Blueberry Supplementation in Midlife for Dementia Risk Reduction
SO NUTRIENTS
LA English
DT Article
DE BMI; insulin resistance; cognition
ID INSULIN-RESISTANCE; ALZHEIMERS-DISEASE; EXECUTIVE FUNCTION; OXIDATIVE
   STRESS; WORKING-MEMORY; OLDER-ADULTS; PEROXISOME PROLIFERATOR; METABOLIC
   SYNDROME; ALPHA-GLUCOSIDASE; NEURONAL FUNCTION
AB Late-life dementia typically develops over a period of many years beginning in midlife. Prevalence of metabolic disturbance also accelerates in middle age and is a prominent risk factor for dementia. Preliminary studies indicate that blueberry supplementation can improve cognitive performance and influence metabolism and brain function and therefore may have a role in early intervention to prevent neurodegeneration. In a randomized controlled trial, we investigated the effects of daily blueberry supplementation in a middle-aged sample of insulin-resistant participants with elevated risk for future dementia. We enrolled overweight men and women, aged 50 to 65 years, with subjective cognitive decline (SCD) and performed pre- and post-intervention assessments of cognition and metabolism and exploratory measures of peripheral mitochondrial function. We observed improved performances for the blueberry group on measures of lexical access, p = 0.003, and memory interference, p = 0.04, and blueberry-treated participants reported reduced memory encoding difficulty in daily life activities, p = 0.03. The blueberry-treated group also exhibited correction of peripheral hyperinsulinemia, p = 0.04, and a modest trend for increased mitochondrial uncoupling, p = 0.11. The cognitive findings indicated improved executive ability in this middle-aged sample. In addition, the changes in metabolic and bioenergetic measures imply potential mechanistic factors associated with anthocyanin and proanthocyanidin actions. The demonstration of these benefits in middle-aged individuals with insulin resistance and SCD suggests that ongoing blueberry supplementation may contribute to protection against cognitive decline when implemented early in at-risk individuals.
C1 [Krikorian, Robert; Shidler, Marcelle D.] Univ Cincinnati, Dept Psychiat & Behav Neurosci, Acad Hlth Ctr, Cincinnati, OH 45267 USA.
   [Skelton, Matthew R.] Cincinnati Childrens Res Fdn, Div Neurol, Cincinnati, OH 45229 USA.
   [Summer, Suzanne S.] Cincinnati Childrens Hosp Med Ctr, Clin Translat Res Ctr, Bionutr Core, Cincinnati, OH 45229 USA.
   [Sullivan, Patrick G.] Univ Kentucky, Chandler Coll Med, Spinal Cord & Brain Injury Res Ctr, Lexington, KY 40506 USA.
C3 University System of Ohio; University of Cincinnati; Cincinnati
   Children's Hospital Medical Center; Cincinnati Children's Hospital
   Research Foundation; Cincinnati Children's Hospital Medical Center;
   University of Kentucky
RP Krikorian, R (corresponding author), Univ Cincinnati, Dept Psychiat & Behav Neurosci, Acad Hlth Ctr, Cincinnati, OH 45267 USA.
EM robert.krikorian@uc.edu; matthew.skelton@cchmc.org;
   suzanne.summer@cchmc.org; shidlemd@ucmail.uc.edu; patsullivan@uky.edu
OI Sullivan, Patrick/0000-0001-7418-4760
FU US Highbush Blueberry Council, Folsom, CA, USA
FX This research was funded by the US Highbush Blueberry Council, Folsom,
   CA, USA. This organization also provided the blueberry powder and
   placebo powder research products.
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NR 99
TC 28
Z9 29
U1 3
U2 25
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD APR
PY 2022
VL 14
IS 8
AR 1619
DI 10.3390/nu14081619
PG 17
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nutrition & Dietetics
GA 0R3YI
UT WOS:000785534400001
PM 35458181
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Ataie, Z
   Dastjerdi, M
   Farrokhfall, K
   Ghiravani, Z
AF Ataie, Zomorrod
   Dastjerdi, Mohammad
   Farrokhfall, Khadijeh
   Ghiravani, Zahra
TI The Effect of Cinnamaldehyde on iNOS Activity and NO-Induced Islet
   Insulin Secretion in High-Fat-Diet Rats
SO EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Article
ID NITRIC-OXIDE PRODUCTION; GENE-TRANSCRIPTION; METABOLIC SYNDROME;
   PANCREATIC-ISLETS; OXIDATIVE STRESS; INHIBITION; RELEASE; CA2+;
   RESISTANCE; HYDROPEROXIDE
AB Introduction. Obesity and insulin resistance are associated with alterations in nitric oxide level and insulin secretion. Previous studies demonstrated that cinnamaldehyde (CNMA) improved islet insulin secretion and restored nitric oxide (NO) level, but its underlying mechanisms have not been investigated. This study aimed to investigate the effect of CNMA on inducible nitric oxide synthase (iNOS) activity and NO-induced islet insulin secretion in high-fat-diet (HFD) treated rats. Materials and Methods. Forty male Wistar rats (12 weeks old) were randomly divided into four equal groups, namely, control, CNMA, HFD, and HFD + CNMA. Control and CNMA groups were treated with standard laboratory animals' diet, while HFD and HDF + CNMA groups were fed with an HFD diet enriched with 25% W/W tail fat for 16 weeks. CNMA was administrated orally (20 mg/kg body weight, daily) during the study period. Islet insulin secretion and the inducible NOS activity in the presence or absence of L-NAME (NO synthase inhibitor, 5 mmol/L) were evaluated. Results. L-NAME-suppressed insulin secretion in control, HFD, and HFD + CNMA groups; however, in the CNMA group, it could not exhibit such effect (P<0.01). Islets of HFD-treated animals showed significantly higher iNOS activity than controls. CNMA treatment significantly suppressed iNOS activities in CNMA and HFD + CNMA groups compared with control and HFD, respectively. Conclusion. These results suggest that the beneficial effect of CNMA on insulin secretion might be due to its inhibitory effect on iNOS activity.
C1 [Ataie, Zomorrod] Islamic Azad Univ, Zahedan Branch, Fac Med, Zahedan, Iran.
   [Dastjerdi, Mohammad] Birjand Univ Med Sci, Med Toxicol & Drug Abuse Res Ctr MTDRC, Birjand, Iran.
   [Farrokhfall, Khadijeh; Ghiravani, Zahra] Birjand Univ Med Sci, Cardiovasc Dis Res Ctr, Birjand, Iran.
C3 Islamic Azad University; Birjand University of Medical Sciences; Birjand
   University of Medical Sciences
RP Farrokhfall, K (corresponding author), Birjand Univ Med Sci, Cardiovasc Dis Res Ctr, Birjand, Iran.
EM emerald.ataie@yahoo.com; mohammaddastjerdi1374@gmail.com;
   kfarrokhfall@yahoo.com; ghiravani@yahoo.com
RI ghiravani, zahra/W-3499-2017; farrokhfall, khadijeh/T-8084-2017
OI dastjerdi, mohammad/0000-0002-3108-488X; Farrokhfal,
   Khadige/0000-0003-0330-4061
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NR 48
TC 11
Z9 14
U1 0
U2 1
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1741-427X
EI 1741-4288
J9 EVID-BASED COMPL ALT
JI Evid.-based Complement Altern. Med.
PD JUL 13
PY 2021
VL 2021
AR 9970678
DI 10.1155/2021/9970678
PG 8
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA TT7JP
UT WOS:000680521200007
PM 34335851
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Rosso, LG
   Lhomme, M
   Meroño, T
   Dellepiane, A
   Sorroche, P
   Hedjazi, L
   Zakiev, E
   Sukhorukov, V
   Orekhov, A
   Gasparri, J
   Chapman, MJ
   Brites, F
   Kontush, A
AF Gomez Rosso, Leonardo
   Lhomme, Marie
   Merono, Tomas
   Dellepiane, Ana
   Sorroche, Patricia
   Hedjazi, Lyamine
   Zakiev, Emile
   Sukhorukov, Vasily
   Orekhov, Alexander
   Gasparri, Julieta
   Chapman, M. John
   Brites, Fernando
   Kontush, Anatol
TI Poor glycemic control in type 2 diabetes enhances functional and
   compositional alterations of small, dense HDL3c
SO BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
LA English
DT Article
DE Type 2 diabetes; HDL; Antioxidative activity; Lipidomics; Functionality
ID APOLIPOPROTEIN-A-I; ELEVATED OXIDATIVE STRESS; CORONARY-HEART-DISEASE;
   BETA-CELL FUNCTION; LIPOPROTEIN CHOLESTEROL; METABOLIC SYNDROME;
   PARTICLE-SIZE; RELEVANCE; RISK; LDL
AB High-density lipoprotein (HDL) possesses multiple biological activities; small, dense HDL3c particles displaying distinct lipidomic composition exert potent antiatherogenic activities which can be compromised in dyslipidemic, hyperglycemic insulin-resistant states. However, it remains indeterminate (i) whether such functional HDL deficiency is related to altered HDL composition, and (ii) whether it originates from atherogenic dyslipidemia, dysglycemia, or both.
   In the present work we analyzed compositional characteristics of HDL subpopulations and functional activity of small, dense HDL3c particles in treatment-nave patients with well-controlled (n = 10) and poorly-controlled (n = 8) type 2 diabetes (T2D) and in normolipidemic age- and sex-matched controls (n = 11).
   Our data reveal that patients with both well- and poorly-controlled T2D displayed dyslipidemia and low-grade inflammation associated with altered HDL composition. Such compositional alterations in small, dense HDL subfractions were specifically correlated with plasma HbA1c levels. Further analysis using a lipidomic approach revealed that small, dense HDL3c particles from T2D patients with poor glycemic control displayed additional modifications of their chemical composition. In parallel, antioxidative activity of HDL3c towards oxidation of low-density lipoprotein was diminished.
   These findings indicate that defective functionality of small, dense HDL particles in patients with T2D is not only affected by the presence of atherogenic dyslipidemia, but also by the level of glycemic control, reflecting compositional alterations of HDL. (C) 2016 Elsevier B.V. All rights reserved.
C1 [Gomez Rosso, Leonardo; Zakiev, Emile; Sukhorukov, Vasily; Chapman, M. John; Kontush, Anatol] INSERM UMR S 1166, Fac Med Pitie Salpetriere, 91 Bld Hop, F-75013 Paris, France.
   [Gomez Rosso, Leonardo; Zakiev, Emile; Sukhorukov, Vasily; Chapman, M. John; Kontush, Anatol] Univ Pierre & Marie Curie Paris 6, Paris, France.
   [Gomez Rosso, Leonardo; Merono, Tomas; Gasparri, Julieta; Brites, Fernando] Univ Buenos Aires, Lab Lipids & Atherosclerosis, Dept Clin Biochem, INFIBIOC,CONICET, Buenos Aires, DF, Argentina.
   [Lhomme, Marie; Hedjazi, Lyamine] Inst Cardiometab & Nutr ICAN, F-75013 Paris, France.
   [Dellepiane, Ana; Hedjazi, Lyamine] Ramon Carrillo Ctr, Buenos Aires, DF, Argentina.
   [Sorroche, Patricia] Italian Hosp, Lab Serv, Buenos Aires, DF, Argentina.
   [Zakiev, Emile; Sukhorukov, Vasily; Orekhov, Alexander] Russian Acad Med Sci, Inst Gen Pathol & Pathophysiol, 8 Baltiyskaya Str, Moscow 125315, Russia.
   [Orekhov, Alexander] Skolkovo Innovat Ctr, Atherosclerosis Res Inst, POB 21, Moscow 121609, Russia.
C3 Institut National de la Sante et de la Recherche Medicale (Inserm);
   Sorbonne Universite; Sorbonne Universite; University of Buenos Aires;
   Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET);
   Sorbonne Universite; Institut National de la Sante et de la Recherche
   Medicale (Inserm); Hospital Italiano de Buenos Aires; Russian Academy of
   Medical Sciences; Institute of General Pathology & Pathophysiology, RAMS
RP Kontush, A (corresponding author), INSERM UMR S 1166, Fac Med Pitie Salpetriere, 91 Bld Hop, F-75013 Paris, France.
EM anatol.kontush@upmc.fr
RI chapman, john/Y-2742-2019; Evelson, Pablo/J-1245-2014; Rosso,
   Leonardo/E-1581-2011; Kontush, Anatol/J-2198-2016; Merono,
   Tomas/T-4060-2017; Sukhorukov, Vasily/H-6545-2016
OI Merono, Tomas/0000-0002-2673-3494; Gomez Rosso,
   Leonardo/0000-0002-4196-2391; Kontush, Anatol/0000-0002-9008-7335;
   LHOMME, MARIE/0000-0002-6335-4506; Sukhorukov,
   Vasily/0000-0002-0312-3773
FU CONICET (Buenos Aires, Argentina); National Institute for Health and
   Medical Research (INSERM, Paris, France) International Cooperation
   Program Inserm-Conicet [1289/11]; ANR (CARINA Project); CODDIM
   Ile-de-France; University of Pierre and Marie Curie (UPMC); University
   of Buenos Aires (UBACyT) [CB23]; Craved Foundation; CONICET [PIP 516]
FX These studies were primarily supported by a collaborative grant from
   CONICET (Buenos Aires, Argentina) and National Institute for Health and
   Medical Research (INSERM, Paris, France) International Cooperation
   Program Inserm-Conicet Res No: 1289/11. We gratefully acknowledge
   further support from the ANR (CARINA Project), CODDIM Ile-de-France,
   University of Pierre and Marie Curie (UPMC), University of Buenos Aires
   (UBACyT CB23), Craved Foundation and CONICET (PIP 516).
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NR 37
TC 31
Z9 32
U1 1
U2 13
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1388-1981
EI 1879-2618
J9 BBA-MOL CELL BIOL L
JI Biochim. Biophys. Acta Mol. Cell Biol. Lipids
PD FEB
PY 2017
VL 1862
IS 2
BP 188
EP 195
DI 10.1016/j.bbalip.2016.10.014
PG 8
WC Biochemistry & Molecular Biology; Biophysics; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Cell Biology
GA EJ0KU
UT WOS:000392898100006
PM 27815221
OA Green Submitted, Green Accepted
DA 2025-06-11
ER

PT J
AU Homayouni-Rad, A
   Soroush, AR
   Khalili, L
   Norouzi-Panahi, L
   Kasaie, Z
   Ejtahed, HS
AF Homayouni-Rad, Aziz
   Soroush, Ahmad-Reza
   Khalili, Leila
   Norouzi-Panahi, Leila
   Kasaie, Zahra
   Ejtahed, Hanieh-Sadat
TI Diabetes Management by Probiotics: Current Knowledge and Future
   Perspectives
SO INTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCH
LA English
DT Review
DE Diabetes; probiotics; intestinal microbiota; future perspectives; gut
   microbes
ID DIET-INDUCED OBESITY; INDUCED HEPATIC STEATOSIS; TOLL-LIKE RECEPTORS;
   GUT MICROBIOTA; LACTOBACILLUS-CASEI; DOUBLE-BLIND; INSULIN-RESISTANCE;
   METABOLIC SYNDROME; CESAREAN-SECTION; HUMAN HEALTH
AB Diabetes mellitus, a multifactorial disorder, is related to the intestinal microbiota via numerous molecular mechanisms. The vast increase in the prevalence of diabetes and its associated complications requires a natural and safe solution. There is a growing evidence of gut microbiota efficiency in improving insulin resistance, impaired insulin secretion, and metabolic complications in diabetic patients. Probiotics are defined as live microorganisms that, when ingested in adequate amounts, exert health benefits to the host. Probiotics can increase insulin sensitivity and reduce autoimmune responses by modulating intestinal microbiota and decreasing the inflammatory reactions and oxidative stress. Recent evidences show that the intestinal microbiota influences the host through modulating intestinal permeability and mucosal immune response, manipulating eating behaviors by appetite-regulating hormones, including agouti related protein (AgRP), glucagon like peptide-1 (GLP-1) and neuropeptide Y, and controlling gut endocannabinoid (eCB) system which is now believed to be associated with inflammation and diabetes. Moreover, intestinal microbiota control the host metabolism by affecting energy extraction from food and by biochemically converting molecules derived from the host or from gut microbes themselves. Experimental studies and clinical trials support the hypothesis that the modulation of the intestinal microbiota by probiotics, especially Lactobacillus and Bifidobacterium strains may be effective in prevention and management of diabetes. This review will highlight the current evidences in probiotic effectiveness and future prospects for exploring probiotic therapy in prevention and control of diabetes.
C1 [Homayouni-Rad, Aziz; Kasaie, Zahra] Tabriz Univ Med Sci, Fac Nutr & Food Sci, Dept Food Sci & Technol, Tabriz, Iran.
   [Soroush, Ahmad-Reza] Univ Tehran Med Sci, Endocrinol & Metab Res Ctr, Endocrinol & Metab Clin Sci Inst, Tehran, Iran.
   [Khalili, Leila] Tabriz Univ Med Sci, Fac Nutr & Food Sci, Dept Nutr, Tabriz, Iran.
   [Norouzi-Panahi, Leila] Islamic Azad Univ, Tabriz Branch, Dept Midwifery, Tabriz, Iran.
   [Ejtahed, Hanieh-Sadat] Univ Tehran Med Sci, Endocrinol & Metab Mol Cellular Sci Inst, Obes & Eating Habits Res Ctr, Tehran, Iran.
C3 Tabriz University of Medical Science; Tehran University of Medical
   Sciences; Tabriz University of Medical Science; Islamic Azad University;
   Tehran University of Medical Sciences
RP Ejtahed, HS (corresponding author), Univ Tehran Med Sci, Endocrinol & Metab Mol Cellular Sci Inst, Obes & Eating Habits Res Ctr, Tehran, Iran.
EM haniejtahed@yahoo.com
RI khalili, leila/AAI-5963-2021; ejtahed, hanieh/AAH-4921-2021; Panahi,
   Leila/AAO-1998-2021; Homayouni Rad, Aziz/L-1508-2017
OI Ejtahed, Hanieh-Sadat/0000-0002-6395-4915; Homayouni Rad,
   Aziz/0000-0001-6766-0108; Norouzi Panahi, Leila/0000-0002-9274-0756
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NR 138
TC 13
Z9 13
U1 1
U2 31
PU HOGREFE AG-HOGREFE AG SUISSE
PI BERN
PA LANGGASSSTRASSE 76, BERN, SWITZERLAND
SN 0300-9831
EI 1664-2821
J9 INT J VITAM NUTR RES
JI Int. J. Vitam. Nutr. Res.
PD OCT
PY 2016
VL 86
IS 5-6
BP 215
EP 227
DI 10.1024/0300-9831/a000273
PG 13
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA VE1XU
UT WOS:000438636600006
PM 28436760
DA 2025-06-11
ER

PT J
AU Shimodaira, M
   Okaniwa, S
   Nakayama, T
AF Shimodaira, Masanori
   Okaniwa, Shinji
   Nakayama, Tomohiro
TI Investigation of the relationship between hemoglobin and serum iron
   levels and early-phase insulin secretion in non-diabetic subjects
SO ACTA DIABETOLOGICA
LA English
DT Article
DE beta-Cell function; Diabetes; Hemoglobin; Insulinogenic index; Iron
ID BETA-CELL FUNCTION; TRANSFERRIN SATURATION; METABOLIC SYNDROME;
   GLUCOSE-TOLERANCE; DIABETES-MELLITUS; OXIDATIVE STRESS; PLASMA-GLUCOSE;
   OBESE JAPANESE; FERRITIN; RESISTANCE
AB Recent biological and epidemiological studies have found that insulin resistance is linked to iron overload. However, little is known about the association between hemoglobin and/or serum iron levels and pancreatic beta-cell function. In this gender-separated cross-sectional study, we aimed to investigate the association of hemoglobin and serum iron levels with early-phase insulin secretion in non-diabetic subjects.
   A total of 804 non-diabetic Japanese subjects (482 males and 322 females) aged over 30 years old were enrolled in the study. Early-phase insulin secretion was estimated using the insulinogenic index (IGI [Delta Insulin((30-0 min))/Delta Glucose((30-0 min))]) during a 75-g oral glucose tolerance test.
   Simple linear regression analysis showed that IGI negatively correlated with hemoglobin levels in male but not in female subjects. However, IGI did not correlate with serum iron levels in either gender. Multivariate linear regression analysis in male subjects revealed that hemoglobin levels were predictors of IGI, responsible for 3.0 % of IGI variation (P = 0.008). The association was independent of age, BMI, fasting glucose and insulin levels, and lipid profiles. In non-diabetic Japanese males, hemoglobin levels significantly and negatively correlated with early-phase insulin secretion.
   Our finding suggests that elevated hemoglobin levels may have a gender-specific impact on beta-cell function and could be an independent predictor of beta-cell dysfunction.
C1 [Shimodaira, Masanori; Okaniwa, Shinji] Iida Municipal Hosp, Dept Internal Med, 438 Yawata Machi, Iida, Nagano 3958502, Japan.
   [Shimodaira, Masanori; Nakayama, Tomohiro] Nihon Univ, Div Compan Diagnost, Dept Pathol Microbiol, Sch Med,Itabashi Ku, 30-1 Ooyaguchi Kamimachi, Tokyo 1738610, Japan.
C3 Nihon University
RP Shimodaira, M (corresponding author), Iida Municipal Hosp, Dept Internal Med, 438 Yawata Machi, Iida, Nagano 3958502, Japan.; Shimodaira, M (corresponding author), Nihon Univ, Div Compan Diagnost, Dept Pathol Microbiol, Sch Med,Itabashi Ku, 30-1 Ooyaguchi Kamimachi, Tokyo 1738610, Japan.
EM masanori19810813@yahoo.co.jp
RI Nakayama, Tomohiro/GYU-0303-2022
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NR 33
TC 7
Z9 7
U1 0
U2 11
PU SPRINGER-VERLAG ITALIA SRL
PI MILAN
PA VIA DECEMBRIO, 28, MILAN, 20137, ITALY
SN 0940-5429
EI 1432-5233
J9 ACTA DIABETOL
JI Acta Diabetol.
PD OCT
PY 2016
VL 53
IS 5
BP 783
EP 789
DI 10.1007/s00592-016-0873-x
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA DV5CD
UT WOS:000382942400012
PM 27311688
DA 2025-06-11
ER

PT J
AU Yang, N
   Yao, Z
   Miao, L
   Liu, J
   Gao, X
   Fan, H
   Hu, YJ
   Zhang, H
   Xu, Y
   Qu, AJ
   Wang, G
AF Yang, Ning
   Yao, Zhi
   Miao, Li
   Liu, Jia
   Gao, Xia
   Fan, Hui
   Hu, Yanjin
   Zhang, Heng
   Xu, Yuan
   Qu, Aijuan
   Wang, Guang
TI Novel Clinical Evidence of an Association between Homocysteine and
   Insulin Resistance in Patients with Hypothyroidism or Subclinical
   Hypothyroidism
SO PLOS ONE
LA English
DT Article
ID CORONARY-HEART-DISEASE; ENDOPLASMIC-RETICULUM STRESS;
   POLYCYSTIC-OVARY-SYNDROME; PLASMA HOMOCYSTEINE; ENDOTHELIAL FUNCTION;
   METABOLIC SYNDROME; THYROID-DISORDERS; ADIPOSE-TISSUE;
   HYPERHOMOCYSTEINEMIA; ATHEROSCLEROSIS
AB Objective
   Hypothyroidism (HO) can induce significant metabolic dysfunction and increase cardiovascular disease risk. In the present study, we investigated the relationship between homocysteine (Hcy) and insulin resistance (IR) in patients with HO or subclinical hypothyroidism (SHO).
   Methods
   A total of 270 subjects were enrolled. All subjects were divided into the following three groups: HO, SHO and control. Plasma levels of Hcy were measured, and each patient's homeostatic index of insulin resistance (HOMA-IR) was calculated. Statistical analyses were carried out to evaluate the correlations among groups and to determine the predictors of IR in patients with HO or SHO.
   Results
   The HOMA-IR value was significantly higher in the HO group than in the SHO and control groups. Plasma levels of Hcy were markedly increased in the HO group compared with those of the SHO group and controls. In addition, plasma levels of Hcy were positively correlated with the HOMA-IR values in both the HO and SHO groups. Multiple linear regression models showed that plasma levels of Hcy and free thyroxine (FT4) were the only predictors of HOMA-IR in patients with HO or SHO.
   Conclusions
   Plasma levels of Hcy and HOMA-IR were increased in patients with HO or SHO. Our results suggest that HO and SHO may increase the risk for atherogenesis and cardiovascular disease by increased IR. The increased IR induced by hyperhomocysteinemia in patients with HO or SHO may partially explain this adverse effect.
C1 [Yang, Ning; Yao, Zhi; Miao, Li; Liu, Jia; Gao, Xia; Fan, Hui; Hu, Yanjin; Zhang, Heng; Xu, Yuan; Wang, Guang] Capital Med Univ, Dept Endocrinol, Beijing Chaoyang Hosp, Beijing, Peoples R China.
   [Qu, Aijuan] Capital Med Univ, Dept Physiol & Pathophysiol, Sch Basic Med Sci, Beijing, Peoples R China.
C3 Capital Medical University; Capital Medical University
RP Qu, AJ (corresponding author), Capital Med Univ, Dept Physiol & Pathophysiol, Sch Basic Med Sci, Beijing, Peoples R China.
EM aijuanqu@ccmu.edu.cn; drwg6688@126.com
RI Wang, Gang/MYQ-4807-2025
FU Major National Basic Research Program of China [2011CB503904]; Beijing
   Natural Science Foundation [7142060]; Chinese National Natural Science
   Foundation [81270369, 81070244]
FX Our work was supported by grants from the Major National Basic Research
   Program of China (No. 2011CB503904), the Beijing Natural Science
   Foundation (No.7142060) and the Chinese National Natural Science
   Foundation (No. 81270369, 81070244) to Guang Wang. The funders had no
   role in study design, data collection and analysis, decision to publish,
   or preparation of the manuscript.
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NR 43
TC 60
Z9 65
U1 0
U2 16
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAY 4
PY 2015
VL 10
IS 5
AR e0125922
DI 10.1371/journal.pone.0125922
PG 10
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA CH3PP
UT WOS:000353943000115
PM 25938439
OA Green Submitted, gold, Green Published
DA 2025-06-11
ER

PT J
AU Hoy, WE
   Bertram, JF
   Denton, RD
   Zimanyi, M
   Samuel, T
   Hughson, MD
AF Hoy, Wendy E.
   Bertram, John F.
   Denton, Rebecca Douglas
   Zimanyi, Monika
   Samuel, Terence
   Hughson, Michael D.
TI Nephron number, glomerular volume, renal disease and hypertension
SO CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION
LA English
DT Review
DE autopsy studies; glomerular number; hypertension; individual glomerular
   volume; mean glomerular volume; nephron number; renal disease
ID CHRONIC KIDNEY-DISEASE; SOUTHEASTERN UNITED-STATES; LOW-BIRTH-WEIGHT;
   BODY-MASS INDEX; AUSTRALIAN ABORIGINES; METABOLIC SYNDROME;
   BLOOD-PRESSURE; AGING KIDNEY; RISK-FACTOR; SIZE
AB Purpose of review
   To discuss studies evaluating associations of glomerular number (Nglom) and glomerular volume with hypertension and kidney disease.
   Important findings
   The association of low Nglom with hypertension and renal insufficiency was described in the 1930s. Many investigators have noted loss of glomeruli with age, with most disappearing entirely, and have proposed that hypertension follows. In a recent German study, hypertensive patients had fewer glomeruli and larger mean glomerular volumes than nonhypertensive people. Among the 10-fold range of Nglom in our multiracial autopsy series, the lowest were in Australian Aborigines, who have the highest rates of renal failure. Nglom fell with age. There was a five-fold range in mean glomerular volume and considerable heterogeneity in individual glomerular volumes within a patient. Larger mean glomerular volume and greater individual glomerular volume heterogeneity correlated with lower Nglom, larger body size, hypertension, and black race. Hypertension increased with age and was marked by glomerular enlargement, intimal thickening and higher rates of glomerulosclerosis. In whites and Aborigines, but not in US blacks, lower Nglom was associated with hypertension, while robust numbers were highly protective.
   Summary
   Higher mean glomerular volume and individual glomerular volume heterogeneity mark glomerular stress. Low Nglom is an important determinant of hypertension and renal disease. Many 'missing' nephrons have probably been lost during life, leaving little trace. Additional factors contribute to high rates of hypertension in blacks.
C1 [Hoy, Wendy E.] Univ Queensland, Ctr Chron Dis, Brisbane, Qld, Australia.
   [Bertram, John F.; Denton, Rebecca Douglas; Zimanyi, Monika; Samuel, Terence] Monash Univ, Dept Anat & Dev Cell Biol, Melbourne, Vic 3004, Australia.
   [Hughson, Michael D.] Univ Mississippi, Sch Med, Dept Pathol, Jackson, MS 39216 USA.
C3 University of Queensland; Monash University; University of Mississippi;
   University of Mississippi Medical Center
RP Hoy, WE (corresponding author), Univ Queensland, Royal Brisbane Hosp, Clin Sci Bldg, Herston, Qld 4029, Australia.
EM w.hoy@uq.edu.au
RI ; Zimanyi, Monika/B-5458-2015; Bertram, John/I-2588-2014; Hoy,
   Wendy/A-7325-2010
OI hughson, michael/0000-0003-1310-707X; Zimanyi,
   Monika/0000-0002-6482-0564; Bertram, John/0000-0001-5863-6464; Hoy,
   Wendy/0000-0002-8405-1539
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NR 67
TC 154
Z9 167
U1 0
U2 13
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1062-4821
EI 1473-6543
J9 CURR OPIN NEPHROL HY
JI Curr. Opin. Nephrol. Hypertens.
PD MAY
PY 2008
VL 17
IS 3
BP 258
EP 265
DI 10.1097/MNH.0b013e3282f9b1a5
PG 8
WC Urology & Nephrology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology; Cardiovascular System & Cardiology
GA 297GS
UT WOS:000255605700003
PM 18408476
DA 2025-06-11
ER

PT J
AU Zou, MH
   Wu, Y
AF Zou, Ming-Hui
   Wu, Yong
TI Amp-activated protein kinase activation as a strategy for protecting
   vascular endothelial function
SO CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
LA English
DT Review
DE AMP-activated kinase; atherosclerosis; diabetes mellitus; endothelium;
   energy metabolism; hypertension; nitric oxide; oxidative stress;
   peroxynitrite; superoxide anions
ID NITRIC-OXIDE SYNTHASE; OXYGEN SPECIES PRODUCTION; RABBIT
   SKELETAL-MUSCLE; FATTY-ACID OXIDATION; FACTOR-KAPPA-B; GENE-EXPRESSION;
   GLUCOSE-CONCENTRATION; INSULIN-RESISTANCE; NAD(P)H OXIDASE; PHOSPHATASE
   2A
AB 1. AMP-activated protein kinase (AMPK) is a serine/threonine protein kinase involved in the regulation of cellular and organismal metabolism. AMPK has a heterotrimeric structure, consisting of a catalytic alpha-subunit and regulatory beta- and gamma-subunits, each of which has two or more isoforms that are differentially expressed in various tissues and that arise from distinct genes. The AMPK system acts as a sensor of cellular energy status that is conserved in all eukaryotic cells. In addition, AMPK is activated by physiological stimuli and oxidants.
   2. The importance of AMPK in cardiovascular functions is best demonstrated by recent studies showing that widely used drugs, including statins, metformin and rosiglitazone, execute cardiovascular protective effects at least partly through the activation of AMPK. As a consequence, AMPK has been proposed as a candidate target for therapeutic intervention in the treatment of both Type 2 diabetes and metabolic syndrome owing to its central role in the regulation of energy balance; it may also have a role in weight control.
   3. In the present brief review, we summarize the recent progress of AMPK signalling and regulation focusing on vascular endothelial cells. We further hypothesize that AMPK is a dual sensor for energy and redox status within a cell and AMPK may be a therapeutic target for protecting vascular endothelial function.
C1 [Zou, Ming-Hui; Wu, Yong] Univ Oklahoma, Hlth Sci Ctr, Dept Med, Sect Endocrinol & Diabet, Oklahoma City, OK 73104 USA.
C3 University of Oklahoma System; University of Oklahoma Health Sciences
   Center
RP Zou, MH (corresponding author), Univ Oklahoma, Hlth Sci Ctr, Dept Med, Sect Endocrinol & Diabet, Oklahoma City, OK 73104 USA.
EM ming-hui-zou@ouhsc.edu
RI ZOU, MING/KYR-3425-2024
FU NHLBI NIH HHS [R01 HL074399, HL080499, T32 HL007439, R01 HL110488, R01
   HL079584, R01 HL080499, R01 HL096032, HL079584, R01 HL105157, R01
   HL089920] Funding Source: Medline
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NR 113
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Z9 119
U1 0
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0305-1870
EI 1440-1681
J9 CLIN EXP PHARMACOL P
JI Clin. Exp. Pharmacol. Physiol.
PD MAY-JUN
PY 2008
VL 35
IS 5-6
BP 535
EP 545
DI 10.1111/j.1440-1681.2007.04851.x
PG 11
WC Pharmacology & Pharmacy; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Physiology
GA 283MP
UT WOS:000254640600001
PM 18177481
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Vieira, AB
   Restrepo, MA
   Auzenne, D
   Molina, K
   O'Sullivan, M
   Machado, MV
   Cavanaugh, SM
AF Vieira, Aline Bomfim
   Restrepo, Mariana Alvarez
   Auzenne, Danielle
   Molina, Kevin
   O'Sullivan, Meghan
   Machado, Marcus Vinicius
   Cavanaugh, Sarah Marie
TI Mild to moderate overweight in dogs: is there an impact on routine
   hematological and biochemical profiles, echocardiographic parameters and
   cardiac autonomic modulation?
SO VETERINARY RESEARCH COMMUNICATIONS
LA English
DT Article
DE Adipose tissue; Autonomic nervous system; Canine; Heart rate
   variability; Obesity
ID HEART-RATE-VARIABILITY; QUALITY-OF-LIFE; OBESE DOGS; SERUM BIOCHEMISTRY;
   METABOLIC SYNDROME; LIPOPROTEIN CONCENTRATIONS; CLINICALLY HEALTHY;
   WEIGHT; CANINE; RESTRICTION
AB Obesity is considered the most common nutritional disease of dogs. Even though overt obesity is more likely to impair health, even moderately overweight dogs are at greater risk for requiring medication for chronic health problems earlier in life. Although the number of overweight dogs far exceeds the number of obese ones, most of the studies published so far focused on derangements in a mixed overweight/obese population (Body condition score - BCS >= 7/9) rather than in separated groups. This study aimed to evaluate the impact of mild to moderate obesity on routine hematological and biochemical profile and cardiovascular parameters in dogs. Nine healthy lean (BCS =4-5/9) and 24 overweight dogs (BCS = 6-7/9) were enrolled. Complete blood count, serum biochemistry analyses, echocardiographic parameters, and cardiac autonomic function by heart rate variability (HRV) were determined. In our study population, although total protein, globulin and phosphorus concentrations were increased in overweight compared to lean dogs, all complete blood count and biochemical parameters were within reference ranges for both groups. Parameters usually increased in obese dogs, like triglycerides and cholesterol concentrations, were within reference ranges in our overweight population. There were no significant changes in echocardiographic parameters, but HRV had a significant decrease in high frequency (HF) power (P = 0.02), suggesting a depression in parasympathetic activity. Our findings show that mild to moderate overweight dogs do not show the hematological and echocardiographic alterations already reported for mixed overweight/obese populations but might have impaired cardiac autonomic modulation. Although not enough to make conclusions, our data raise the question of whether research studies should place overweight and obese dogs in the same category.
C1 [Vieira, Aline Bomfim; Restrepo, Mariana Alvarez; Auzenne, Danielle; Molina, Kevin; O'Sullivan, Meghan; Machado, Marcus Vinicius; Cavanaugh, Sarah Marie] Ross Univ, Sch Vet Med RUSVM, Biomed Dept, POB 334, Basseterre, West Indies, St Kitts & Nevi.
RP Vieira, AB (corresponding author), Ross Univ, Sch Vet Med RUSVM, Biomed Dept, POB 334, Basseterre, West Indies, St Kitts & Nevi.
EM AVieira@rossvet.edu.kn
OI Molina, Kevin/0000-0003-3023-1910; Cavanaugh, Sarah/0000-0003-0406-2631;
   Vieira, Aline/0000-0002-2479-6774
FU RUSVM Intramural Grant [42014-2019]; RUSVM center for integrative
   mammalian research; Morris Animal Foundation
FX This study was funded by RUSVM Intramural Grant (Grant number:
   42014-2019) and supported by the RUSVM center for integrative mammalian
   research. The second author (MAR) received a student scholarship from
   Morris Animal Foundation. The funding sources had no involvement in the
   study design, data collection, analysis, writing of the report or
   decision to publish.
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NR 50
TC 5
Z9 5
U1 1
U2 10
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0165-7380
EI 1573-7446
J9 VET RES COMMUN
JI Vet. Res. Commun.
PD JUN
PY 2022
VL 46
IS 2
BP 527
EP 535
DI 10.1007/s11259-021-09880-6
EA JAN 2022
PG 9
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA 1N9GT
UT WOS:000741272800001
PM 35018593
DA 2025-06-11
ER

PT J
AU Kerr, WC
   Ye, Y
AF Kerr, William C.
   Ye, Yu
TI Relationship of Life-Course Drinking Patterns to Diabetes, Heart
   Problems, and Hypertension Among Those 40 and Older in the 2005 US
   National Alcohol Survey
SO JOURNAL OF STUDIES ON ALCOHOL AND DRUGS
LA English
DT Article
ID PROPENSITY-SCORE; METABOLIC SYNDROME; UNITED-STATES; RISK; MORTALITY;
   CONSUMPTION; DISEASE; ADULTS; METAANALYSIS; PREVALENCE
AB Objective: The goal of this study was to estimate relationships between life-course drinking patterns and the risks of self-reported diabetes, heart problems, and hypertension. Method: Respondents to the 2005 National Alcohol Survey, age 40 and older, reported ever having a doctor or health professional diagnose each of the health-problem outcomes. Retrospective earlier-life drinking patterns were characterized by lifetime abstention and the frequency of 5+ drinking days (i.e., days on which five or more drinks were consumed) in the respondent's teens, 20s, and 30s. Past-year drinking patterns were measured through intake volume and 5+ days. Potential confounders in the domains of demographics, socioeconomic resources, and other health-risk variables that is, depression, distress, sense of coherence, body mass index, tobacco use, marijuana use, childhood abuse, and family history of alcohol problems were controlled through propensity-score matching. Results: After matching, lifetime abstainers were found to be at increased risk of diabetes compared with both lifetime and current moderate drinkers. Exdrinkers were found to be at increased risk of diabetes, heart problems, and hypertension. Higher volume drinkers without monthly 5+ days were found to be at reduced risk of diabetes relative to moderate-volume current drinkers. Heavy-occasion drinkers were found to be at increased risk of hypertension. Conclusions: Regular lower quantity alcohol intake may be protective against adult onset of diabetes, but no evidence of protection from heart problems or hypertension was found. Both life course defined and past year defined drinking groups exhibit substantial clustering of confounding risk variables, indicating the need for modeling strategies like propensity-score matching. Increased risks among exdrinkers suggest a substantial "sick-quitter" effect. (J. Stud. Alcohol Drugs, 71, 515-525, 2010)
C1 [Kerr, William C.; Ye, Yu] Alcohol Res Grp, Emeryville, CA 94608 USA.
C3 Alcohol Research Group
RP Kerr, WC (corresponding author), Alcohol Res Grp, 6475 Christie Ave,Suite 400, Emeryville, CA 94608 USA.
EM wkerr@arg.org
RI Ye, Yu/V-7651-2019
OI Ye, Yu/0000-0002-2336-3803
FU National Institute on Alcohol Abuse and Alcoholism; National Alcohol
   Research Center [P30-AA05595]
FX This research was supported by National Institute on Alcohol Abuse and
   Alcoholism, National Alcohol Research Center grant P30-AA05595 awarded
   to Thomas K. Greenfield (principal investigator), Alcohol Research
   Group, Public Health Institute, Emeryville, CA.
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NR 48
TC 42
Z9 46
U1 0
U2 16
PU ALCOHOL RES DOCUMENTATION INC CENT ALCOHOL STUD RUTGERS UNIV
PI PISCATAWAY
PA C/O DEIRDRE ENGLISH, 607 ALLISON RD, PISCATAWAY, NJ 08854-8001 USA
SN 1937-1888
EI 1938-4114
J9 J STUD ALCOHOL DRUGS
JI J. Stud. Alcohol Drugs
PD JUL
PY 2010
VL 71
IS 4
BP 515
EP 525
DI 10.15288/jsad.2010.71.515
PG 11
WC Substance Abuse; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Substance Abuse; Psychology
GA 619EA
UT WOS:000279410800006
PM 20553659
OA Green Published
DA 2025-06-11
ER

PT J
AU Kulakova, E
   Uesekes, B
   Hellmann-Regen, J
   Spitzer, C
   Kuehl, LK
   Otte, C
   Wingenfeld, K
AF Kulakova, Eugenia
   Uesekes, Berk
   Hellmann-Regen, Julian
   Spitzer, Carsten
   Kuehl, Linn K.
   Otte, Christian
   Wingenfeld, Katja
TI Adipokines in depressed women with and without adverse childhood
   experiences
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE Major depressive disorder; Adverse childhood experience; Adipokines;
   Leptin; Adiponectin; RBP4
ID BINDING-PROTEIN 4; EARLY-LIFE STRESS; GLUCOCORTICOID-RESISTANCE;
   METABOLIC SYNDROME; RISK; ADIPONECTIN; LEPTIN; DISORDER; DISEASE;
   MALTREATMENT
AB Background: Adverse childhood experiences (ACE) elevate the risk of both major depressive disorder (MDD) and metabolic diseases. The underlying pathophysiology might include alterations of adipokine levels as a consequence of ACE. In this study, we used a full -factorial design to investigate the levels of select adipokines in women with ACE -only (n = 23), MDD-only (n = 27), ACE +MDD (n = 25) and healthy controls (HC, n = 29) to identify metabolic makers associated with vulnerability and resilience of developing MDD after ACE exposure. Methods: Serum levels of adiponectin, leptin, adiponectin-to-leptin (A/L) ratio, and retinol binding protein 4 (RBP4) were measured using enzyme -linked immunosorbent assay (ELISA). Results: Adiponectin levels did not differ between groups. Individuals with vs. without MDD showed higher leptin serum concentrations. As predicted, A/L ratio indicated lower values in individuals with vs. without ACE. RBP4 showed a more nuanced pattern with reduced levels in the ACE -only and MDD-only groups compared to HC. Furthermore, the ACE -only group showed lower RBP4 concentrations compared to ACE +MDD. These results were not accounted by BMI or medication status. Conclusion: Our results do not support the utility of adiponectin and leptin as predictors of vulnerability or resilience of developing MDD after ACE. In contrast, RBP4 might play a role in resilience towards the development of MDD following ACE. Further research on this more recently discovered adipokine seems warranted.
C1 [Kulakova, Eugenia; Uesekes, Berk; Hellmann-Regen, Julian; Otte, Christian; Wingenfeld, Katja] Charite Univ Med Berlin, Berlin, Germany.
   [Kulakova, Eugenia; Uesekes, Berk; Hellmann-Regen, Julian; Otte, Christian; Wingenfeld, Katja] Free Univ Berlin, Berlin, Germany.
   [Kulakova, Eugenia; Uesekes, Berk; Hellmann-Regen, Julian; Otte, Christian; Wingenfeld, Katja] Humboldt Univ, Berlin, Germany.
   [Kulakova, Eugenia; Uesekes, Berk; Hellmann-Regen, Julian; Otte, Christian; Wingenfeld, Katja] Berlin Inst Hlth, Klin Psychiat & Psychotherapie, Campus Benjamin Franklin, Berlin, Germany.
   [Kulakova, Eugenia; Hellmann-Regen, Julian; Otte, Christian; Wingenfeld, Katja] DZPG German Ctr Mental Hlth, Partner Site, Berlin, Germany.
   [Spitzer, Carsten] Univ Med Ctr Rostock, Dept Psychosomat Med & Psychotherapy, Rostock, Germany.
   [Kuehl, Linn K.] MSB Med Sch Berlin, Dept Psychol Clin Psychol & Psychotherapy, Berlin, Germany.
   [Kulakova, Eugenia] Charite Univ Med Berlin, Dept Psychiat & Psychotherapy, Campus Benjamin Franklin,Hindenburgdamm 30, D-12203 Berlin, Germany.
C3 Berlin Institute of Health; Free University of Berlin; Humboldt
   University of Berlin; Charite Universitatsmedizin Berlin; Free
   University of Berlin; Humboldt University of Berlin; Berlin Institute of
   Health; Free University of Berlin; Humboldt University of Berlin;
   Charite Universitatsmedizin Berlin; University of Rostock; Berlin
   Institute of Health; Free University of Berlin; Humboldt University of
   Berlin; Charite Universitatsmedizin Berlin
RP Kulakova, E (corresponding author), Charite Univ Med Berlin, Dept Psychiat & Psychotherapy, Campus Benjamin Franklin,Hindenburgdamm 30, D-12203 Berlin, Germany.
EM Eugenia.kulakova@charite.de
OI Kuehl, Linn/0000-0001-6871-6302; Wingenfeld, Katja/0000-0001-7457-0370;
   Otte, Christian/0000-0002-4051-997X
FU Deutsche Forschungsgemeinschaft (DFG) [WI 3396/6-1, SP 579/3-1]; BIH
   Charite Clinician Scientist Program; DFG [HE-6939/3-1]
FX The study was supported by a grant of the Deutsche
   Forschungsgemeinschaft (DFG; WI 3396/6-1 & SP 579/3-1) awarded to KW, CS
   and CO. JHR received funding through the BIH Charite Clinician Scientist
   Program and DFG (HE-6939/3-1) .
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NR 41
TC 0
Z9 0
U1 0
U2 0
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
EI 1873-3360
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD JUN
PY 2024
VL 164
AR 107026
DI 10.1016/j.psyneuen.2024.107026
EA MAR 2024
PG 5
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA PT6U1
UT WOS:001216382600001
PM 38507869
OA hybrid
DA 2025-06-11
ER

PT J
AU Sinclair, SH
   Schwartz, SS
AF Sinclair, Stephen H.
   Schwartz, Stanley S.
TI Diabetic Retinopathy-An Underdiagnosed and Undertreated Inflammatory,
   Neuro-Vascular Complication of Diabetes
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Article
DE diabetic retinopathy; epigenetics; insulin resistance; inflammation;
   neurovascular; neurodegeneration; complications; microvascular
ID RETINAL GANGLION-CELLS; EPITHELIUM-DERIVED FACTOR; NERVE GROWTH-FACTOR;
   OXIDATIVE STRESS; MACULAR EDEMA; ERYTHROPOIETIN PROTECTS; METABOLIC
   SYNDROME; MULLER CELLS; RISK-FACTORS; NEURODEGENERATION
AB Diabetes mellitus is a world-wide epidemic and diabetic retinopathy, a devastating, vision-threatening condition, is one of the most common diabetes-specific complications. Diabetic retinopathy is now recognized to be an inflammatory, neuro-vascular complication with neuronal injury/dysfunction preceding clinical microvascular damage. Importantly, the same pathophysiologic mechanisms that damage the pancreatic beta-cell (e.g., inflammation, epigenetic changes, insulin resistance, fuel excess, and abnormal metabolic environment), also lead to cell and tissue damage causing organ dysfunction, elevating the risk of all complications, including diabetic retinopathy. Viewing diabetic retinopathy within the context whereby diabetes and all its complications arise from common pathophysiologic factors allows for the consideration of a wider array of potential ocular as well as systemic treatments for this common and devastating complication. Moreover, it also raises the importance of the need for methods that will provide more timely detection and prediction of the course in order to address early damage to the neurovascular unit prior to the clinical observation of microangiopathy. Currently, treatment success is limited as it is often initiated far too late and after significant neurodegeneration has occurred. This forward-thinking approach of earlier detection and treatment with a wider array of possible therapies broadens the physician's armamentarium and increases the opportunity for prevention and early treatment of diabetic retinopathy with preservation of good vision, as well the prevention of similar destructive processes occurring among other organs.
C1 [Sinclair, Stephen H.] Sinclair Retina Associates, Media, PA 19063 USA.
   [Sinclair, Stephen H.] Main Line Hlth Syst, Media, PA 19063 USA.
RP Sinclair, SH (corresponding author), Sinclair Retina Associates, Media, PA 19063 USA.; Sinclair, SH (corresponding author), Main Line Hlth Syst, Media, PA 19063 USA.
EM ssinclair@stephensinclairmd.com
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NR 141
TC 93
Z9 99
U1 1
U2 14
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD DEC 13
PY 2019
VL 10
AR 843
DI 10.3389/fendo.2019.00843
PG 14
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA JY9LC
UT WOS:000504726600001
PM 31920963
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Lucas, BD
   Barbosa, TD
   Castelo, PM
   Gaviao, MBD
AF Lucas, Barbara de Lima
   Barbosa, Tais de Souza
   Castelo, Paula Midori
   Duarte Gaviao, Maria Beatriz
TI Salivary alpha-amylase and hormones levels of young adults with
   different body composition
SO JOURNAL OF TEXTURE STUDIES
LA English
DT Article
DE adiposity; alpha-amylase; saliva; skinfold thickness; steroids
ID PITUITARY-ADRENAL AXIS; METABOLIC SYNDROME; SEX-DIFFERENCES; CORTISOL;
   OBESITY; STRESS; ENERGY; FAT; DETERMINANTS; OVERWEIGHT
AB The aim of this study was to assess the differences in salivary biomarker levels of young adults classified according to body fat accumulation. One hundred and thirty-four volunteers were evaluated (mean age 212years). Body composition was calculated through skinfold thickness: supra-iliac, biceps, and triceps, sub-scapular. Body fat percentage (BF%) was used to classify subjects according to fat tissue accumulation: normal-weight (n=37, 19 females, 18 males), overweight (n=42, 30 females, 12 males), and obese (n=55, 42 females, 13 males). Saliva samples were collected 30min after awakening to determine salivary levels of 17-beta-estradiol. For salivary cortisol and alpha-amylase activity (sAA) three samples were obtained, just after awakening, 30min after awakening and at bedtime. Oral contraceptive intake was considered for the female group. The results showed that overweight and obese females using oral contraceptive presented lower levels of 17--estradiol than normal-weight females. In overweight and obese males, sAA levels were higher 30min post-awakening when compared with the normal-weight group. The comparison of sAA levels within time showed no difference for males; obese females showed significant higher values at bedtime than 30 min post-awakening. The salivary cortisol concentration showed higher values at morning decreasing significantly at bedtime for all groups. Concluding, differences in 17--estradiol and sAA levels were found in females and males, respectively, according to body fat accumulation, showing the usefulness of salivary biomarkers in the study of systemic conditions.
C1 [Lucas, Barbara de Lima] Univ Fed Goias, Hlth Sci Special Unit, Jatai, Go, Brazil.
   [Barbosa, Tais de Souza] Univ Fed Juiz de Fora, Inst Life Sci, Dept Dent, Governador Valadares, MG, Brazil.
   [Castelo, Paula Midori] Fed Univ Sao Paulo UNIFESP, Dept Pharmaceut Sci, Sao Paulo, Brazil.
   [Lucas, Barbara de Lima; Barbosa, Tais de Souza; Castelo, Paula Midori; Duarte Gaviao, Maria Beatriz] Univ Estadual Campinas, Piracicaba Dent Sch, Dept Pediat Dent, Sao Paulo, Brazil.
C3 Universidade Federal de Goias; Universidade Federal de Juiz de Fora;
   Universidade Federal de Sao Paulo (UNIFESP); Universidade Estadual de
   Campinas
RP Gaviao, MBD (corresponding author), Univ Estadual Campinas, Fac Odontol Piracicaba, Dept Odontol Infantil, Ave Limeira 901, BR-13414903 Piracicaba, SP, Brazil.
EM mbgaviao@fop.unicamp.br
RI Barbosa, Tais/A-2241-2013; Gavião, Maria/AGJ-4336-2022; de Lima Lucas,
   Barbara/E-2853-2010; DUARTE GAVIAO, MARIA BEATRIZ/C-3991-2012; Castelo,
   Paula Midori/I-6922-2012
OI de Lima Lucas, Barbara/0000-0003-2829-0508; Barbosa,
   Tais/0000-0002-3479-7789; DUARTE GAVIAO, MARIA
   BEATRIZ/0000-0002-7546-5262; Castelo, Paula Midori/0000-0001-8703-2272
FU Conselho Nacional de Desenvolvimento Cientifico e Tecnologico
   [309588/2011-1]; State of Sao Paulo Research Foundation; Universidade
   Estadual de Campinas [2010/19616-3, 2010/02020-0]; Fundacao de Amparo a
   Pesquisa do Estado de Sao Paulo (FAPESP) [10/19616-3] Funding Source:
   FAPESP
FX Conselho Nacional de Desenvolvimento Cientifico e Tecnologico,
   Grant/Award Number: 309588/2011-1; State of Sao Paulo Research
   Foundation; Universidade Estadual de Campinas, Grant/Award Numbers: n.
   2010/19616-3, n. 2010/02020-0
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NR 44
TC 6
Z9 7
U1 2
U2 13
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-4901
EI 1745-4603
J9 J TEXTURE STUD
JI J. Texture Stud.
PD FEB
PY 2019
VL 50
IS 1
SI SI
BP 45
EP 52
DI 10.1111/jtxs.12384
PG 8
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Food Science & Technology
GA HL4CJ
UT WOS:000458662600006
PM 30561102
DA 2025-06-11
ER

PT J
AU Yin, J
   Li, YY
   Han, H
   Chen, S
   Gao, J
   Liu, G
   Wu, X
   Deng, JP
   Yu, QF
   Huang, XG
   Fang, RJ
   Li, TJ
   Reiter, RJ
   Zhang, D
   Zhu, CR
   Zhu, GQ
   Ren, WK
   Yin, YL
AF Yin, Jie
   Li, Yuying
   Han, Hui
   Chen, Shuai
   Gao, Jing
   Liu, Gang
   Wu, Xin
   Deng, Jinping
   Yu, Qifang
   Huang, Xingguo
   Fang, Rejun
   Li, Tiejun
   Reiter, Russel J.
   Zhang, Dong
   Zhu, Congrui
   Zhu, Guoqiang
   Ren, Wenkai
   Yin, Yulong
TI Melatonin reprogramming of gut microbiota improves lipid dysmetabolism
   in high-fat diet-fed mice
SO JOURNAL OF PINEAL RESEARCH
LA English
DT Article
DE acetic acid; gut microbiota; lipid metabolism; melatonin; microbiota
   transplantation
ID AMINO-ACID-METABOLISM; ARGININE SUPPLEMENTATION; INFLAMMATORY RESPONSES;
   ANTIOXIDANT SYSTEM; OXIDATIVE STRESS; INNATE IMMUNITY; INDUCED OBESITY;
   RESTRICTION; ACTIVATION; EXPRESSION
AB Melatonin has been shown to improve lipid metabolism and gut microbiota communities in animals and humans; however, it remains to know whether melatonin prevents obesity through gut microbiota. Here, we found that high-fat diet promoted the lipid accumulation and intestinal microbiota dysbiosis in mice, while oral melatonin supplementation alleviated the lipid accumulation and reversed gut microbiota dysbiosis, including the diversity of intestinal microbiota, relative abundances of Bacteroides and Alistipes, and functional profiling of microbial communities, such as energy metabolism, lipid metabolism, and carbohydrate metabolism. Interestingly, melatonin failed to alleviate the high-fat-induced lipid accumulation in antibiotic-treated mice; however, microbiota transplantation from melatonin-treated mice alleviated high-fat diet-induced lipid metabolic disorders. Notably, short-chain fatty acids were decreased in high-fat diet-fed mice, while melatonin treatment improved the production of acetic acid. Correlation analysis found a marked correlation between production of acetic acid and relative abundances of Bacteroides and Alistipes. Importantly, sodium acetate treatment also alleviated high-fat diet-induced lipid metabolic disorders. Taken together, our results suggest that melatonin improves lipid metabolism in high-fat diet-fed mice, and the potential mechanisms may be associated with reprogramming gut microbiota, especially, Bacteroides and Alistipes-mediated acetic acid production. Future studies are needed for patients with metabolic syndrome to fully understand melatonin's effects on body weight and lipid profiles and the potential mechanism of gut microbiota.
C1 [Yin, Jie; Li, Yuying; Han, Hui; Chen, Shuai; Gao, Jing; Liu, Gang; Wu, Xin; Li, Tiejun; Yin, Yulong] Chinese Acad Sci, Inst Subtrop Agr, Key Lab Agroecol Proc Subtrop Reg, Changsha, Hunan, Peoples R China.
   [Yin, Jie; Li, Yuying; Han, Hui; Chen, Shuai; Gao, Jing; Liu, Gang; Wu, Xin; Li, Tiejun; Yin, Yulong] Hunan Prov Key Lab Anim Nutr Physiol & Metab Proc, Changsha, Hunan, Peoples R China.
   [Yin, Jie; Deng, Jinping; Ren, Wenkai; Yin, Yulong] South China Agr Univ, Coll Anim Sci, Inst Subtrop Anim Nutr & Feed, Guangdong Prov Key Lab Anim Nutr Control, Guangzhou, Guangdong, Peoples R China.
   [Yin, Jie; Li, Yuying; Han, Hui; Chen, Shuai; Gao, Jing] Univ Chinese Acad Sci, Beijing, Peoples R China.
   [Yu, Qifang; Huang, Xingguo; Fang, Rejun] Hunan Agr Univ, Dept Anim Sci, Changsha, Hunan, Peoples R China.
   [Yu, Qifang; Huang, Xingguo; Fang, Rejun] Hunan Coinnovat Ctr Anim Prod Safety, Changsha, Hunan, Peoples R China.
   [Reiter, Russel J.] Univ Texas Hlth Sci Ctr San Antonio, Dept Cellular & Struct Biol, San Antonio, TX 78229 USA.
   [Zhang, Dong; Zhu, Guoqiang; Ren, Wenkai] Yangzhou Univ, Jiangsu Coinnovat Ctr Important Anim Infect Dis &, Joint Int Res Lab Agr & Agri Prod Safety, Minist Educ China,Coll Vet Med, Yangzhou, Jiangsu, Peoples R China.
   [Zhu, Congrui] Kansas State Univ, Coll Vet Med, Manhattan, KS 66506 USA.
C3 Chinese Academy of Sciences; Institute of Subtropical Agriculture, CAS;
   South China Agricultural University; Chinese Academy of Sciences;
   University of Chinese Academy of Sciences, CAS; Hunan Agricultural
   University; University of Texas System; University of Texas Health
   Science Center at San Antonio; Yangzhou University; Ministry of
   Education - China; Kansas State University
RP Wu, X; Li, TJ (corresponding author), Chinese Acad Sci, Inst Subtrop Agr, Key Lab Agroecol Proc Subtrop Reg, Changsha, Hunan, Peoples R China.; Ren, WK (corresponding author), South China Agr Univ, Coll Anim Sci, Inst Subtrop Anim Nutr & Feed, Guangdong Prov Key Lab Anim Nutr Control, Guangzhou, Guangdong, Peoples R China.
EM wuxin@isa.ac.cn; tjli@isa.ac.cn; renwenkai19@126.com
RI Wu, Xin/ITU-1370-2023; Liu, Gang/AAE-3853-2020; YIN, Jie/H-3578-2019;
   li, yuying/JDW-4642-2023; gao, jing/HRD-0768-2023; Reiter,
   Russel/D-3221-2009; Han, Hui/AGS-7646-2022; CHEN, Shuai/O-1255-2018
OI Li, Yuying/0000-0003-0165-8018; Chen, Shuai/0000-0002-9337-6191; Han,
   Hui/0000-0002-8163-8932; Zhu, Congrui/0000-0002-0905-9979
FU National Key Research and Development Program [2016YFD0501200,
   2016YFD0500500]; National Natural Science Foundation of China [31472106,
   31772617, 31872365, 31790411]; Chinese Academy of Sciences
   [QYZDY-SSWSMC008]; Hunan Key Research Program [2017NK2320]
FX National Key Research and Development Program, Grant/Award Numbers:
   2016YFD0501200 and 2016YFD0500500; National Natural Science Foundation
   of China, Grant/Award Numbers: 31472106, 31772617, 31872365 and
   31790411; Chinese Academy of Sciences, Grant/Award Number:
   QYZDY-SSWSMC008; Hunan Key Research Program, Grant/Award Number:
   2017NK2320
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NR 67
TC 322
Z9 343
U1 11
U2 358
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0742-3098
EI 1600-079X
J9 J PINEAL RES
JI J. Pineal Res.
PD NOV
PY 2018
VL 65
IS 4
AR e12524
DI 10.1111/jpi.12524
PG 18
WC Endocrinology & Metabolism; Neurosciences; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Physiology
GA GX8YF
UT WOS:000448081600008
PM 30230594
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Modi, A
   Morou-Bermudez, E
   Vergara, J
   Patel, RP
   Nichols, A
   Joshipura, K
AF Modi, Ashwin
   Morou-Bermudez, Evangelia
   Vergara, Jose
   Patel, Rakesh P.
   Nichols, Alexandria
   Joshipura, Kaumudi
TI Validation of two point-of-care tests against standard lab measures of
   NO in saliva and in serum
SO NITRIC OXIDE-BIOLOGY AND CHEMISTRY
LA English
DT Article
ID NITRIC-OXIDE SYNTHESIS; SMOKERS; PLASMA; DISEASE; NITRATE; STRESS
AB Nitric oxide (NO) is an endogenous signaling molecule, which plays important roles in cardiometabolic health. A significant source of NO is dietary nitrate (NO3), which is initially metabolized by oral bacteria into nitrite (NO2- and is subsequently converted into NO once digested in the acidic gastric environment. Inexpensive non-invasive tests for measuring nitrite from saliva have been developed as a means for individuals to monitor their NO bioavailability. However, few studies exist in the literature validating and comparing these products with standard lab assays. The objective of this study was to validate two commonly used commercial strips: Nitric Oxide Test Strips (Berkeley Test) and Nitric Oxide Indicator Strips (Neogenesis) against standard lab measures for saliva and serum nitrite/nitrate. A stratified random sample of 20 non-smoking, overweight or obese participants between 40 to 65 years of age, were selected for this study from the baseline data of the San Juan Overweight Adults Longitudinal Study (SOALS). There was a significant correlation between the measures from the two nitrite-detecting-strips after controlling for the stratification variables (metabolic syndrome, and mouthwash use) (r = 0.75). Measurements from both strips correlated significantly with salivary nitrite levels (r = 0.76 for Berkeley strips; r = 0.59 for Neogenesis). Neither of the strips had a significant correlation with the levels of saliva nitrate, serum nitrite and serum nitrate. In conclusion, commercially available Berkeley and Neogenesis strips provide a reasonable surrogate for salivary, but not for systemic nitrite levels. (C) 2017 Elsevier Inc. All rights reserved.
C1 [Modi, Ashwin; Vergara, Jose; Joshipura, Kaumudi] Univ Puerto Rico, Ctr Clin Res & Hlth Promot, Med Sci Campus, San Juan, PR 00936 USA.
   [Morou-Bermudez, Evangelia] Univ Puerto Rico, Sch Dent Med, San Juan, PR 00936 USA.
   [Patel, Rakesh P.] UAB, Dept Pathol, Birmingham, AL 35294 USA.
   [Patel, Rakesh P.] UAB, Ctr Free Radical Biol, Birmingham, AL 35294 USA.
   [Nichols, Alexandria] UAB, Sch Med, Birmingham, AL 35294 USA.
   [Joshipura, Kaumudi] Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA.
C3 University of Puerto Rico; University of Puerto Rico Medical Sciences
   Campus; University of Puerto Rico; University of Puerto Rico Medical
   Sciences Campus; University of Alabama System; University of Alabama
   Birmingham; University of Alabama System; University of Alabama
   Birmingham; University of Alabama System; University of Alabama
   Birmingham; Harvard University; Harvard T.H. Chan School of Public
   Health
RP Joshipura, K (corresponding author), Univ Puerto Rico, Ctr Clin Res & Hlth Promot, Med Sci Campus, San Juan, PR 00936 USA.
EM kaumudi.joshipura@upr.edu
RI Joshipura, Kaumudi/AAA-3852-2020; Patel, Manishkumar/ABB-9838-2020;
   Modi, Ashwinkumar/G-9924-2017
OI Modi, Ashwinkumar/0000-0002-4445-1212; Patel, Rakesh/0000-0002-1526-4303
FU National Institute of Dental and Craniofacial Research [R01DE020111];
   National Institute on Minority Health and Health Disparities
   [U54MD007587]; NIH [P30 DK079626/DK/NIDDK, UH2 TR000923, U01DE17593, RO1
   CA139596, R01 DE17170, R21 CA0126733, PRSTT 2013-000016]; UAB Diabetes
   Research Center BioAnalytical Redox Biology (BARB) Core; Barnes; O'Keefe
   Foundation
FX We would like to acknowledge the SOALS team (Dr. Cynthia Perez, Ms.
   Elaine Rodriguez, Ms. Maria Del Mar Rodriguez, Ms. Rosalyn Roman, Ms.
   Yadiris Santaella, Ms. Grace Velez, Mr. Francisco Munoz) for their help
   with the study. We would also like to acknowledge the PRCTRC laboratory
   personnel (Mrs. Nilda Gonzalez and Mrs. Aracelis Arroyo) for their help
   during the blood and saliva processing, and Dr. David Wong for support
   on the saliva collection. The content is solely the responsibility of
   the authors and does not necessarily represent the official views of the
   National Institutes of Health. Research reported in this publication was
   supported by the National Institute of Dental and Craniofacial Research
   Grant R01DE020111, the National Institute on Minority Health and Health
   Disparities Grant U54MD007587 and the P30 DK079626/DK/NIDDK NIH, UAB
   Diabetes Research Center BioAnalytical Redox Biology (BARB) Core, NIH
   grants UH2 TR000923, U01DE17593, RO1 CA139596, R01 DE17170, R21
   CA0126733, PRSTT 2013-000016, the Barnes Fund for Head & Neck Cancer
   Research and the O'Keefe Foundation.
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NR 45
TC 7
Z9 7
U1 1
U2 9
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 1089-8603
EI 1089-8611
J9 NITRIC OXIDE-BIOL CH
JI Nitric Oxide-Biol. Chem.
PD APR 1
PY 2017
VL 64
BP 16
EP 21
DI 10.1016/j.niox.2017.01.009
PG 6
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA EN2PS
UT WOS:000395853000003
PM 28153714
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Kruse, M
   von Loeffelholz, C
   Hoffmann, D
   Pohlmann, A
   Seltmann, AC
   Osterhoff, M
   Hornemann, S
   Pivovarova, O
   Rohn, S
   Jahreis, G
   Pfeiffer, AFH
AF Kruse, Michael
   von Loeffelholz, Christian
   Hoffmann, Daniela
   Pohlmann, Antje
   Seltmann, Anne-Cathrin
   Osterhoff, Martin
   Hornemann, Silke
   Pivovarova, Olga
   Rohn, Sascha
   Jahreis, Gerhard
   Pfeiffer, Andreas F. H.
TI Dietary rapeseed/canola-oil supplementation reduces serum lipids and
   liver enzymes and alters postprandial inflammatory responses in adipose
   tissue compared to olive-oil supplementation in obese men
SO MOLECULAR NUTRITION & FOOD RESEARCH
LA English
DT Article
DE Inflammation; Obesity; Olive oil; Rapeseed oil; Serum lipids
ID POLYUNSATURATED FATTY-ACIDS; ALPHA-LINOLENIC ACID;
   TUMOR-NECROSIS-FACTOR; STRESS SIGNALING PATHWAY; HEALTHY-MEN; METABOLIC
   SYNDROME; VEGETABLE-OIL; TNF-ALPHA; FISH-OIL; INTERLEUKIN-6
AB Scope: Obesity is associated with hyperlipidemia, hepatic steatosis, and low-grade inflammation. Studies have shown that MUFA as well as PUFA have beneficial effects on blood lipids and the inflammatory state.
   Methods and results: This study investigates the effects of a daily supplementation of either 50 g of rapeseed/canola (RA) or olive (OL) oil over 4 wk on serum lipids, serum liver enzymes, and inflammatory gene expression in subcutaneous (s. c.) adipose tissue in obese men. Consuming RA resulted in increased serum n-3 fatty acids and a reduction in total cholesterol, LDL cholesterol, and serum aspartate aminotransferase compared to OL. In s. c. adipose tissue, gene expression of the pro-inflammatory cytokine IL6 was reduced in RA compared to OL. However, after 4 h after a test meal, containing the appropriate oil, white bread, and 400 mL of liquid diet drink (835 kcal in total), gene expression of IL6, IL1B, and EMR1 (egf-like module containing Mucin-like hormone receptor-like 1) was increased in RA and of monocyte chemoattractant protein-1 (CCL2) in both RA and OL.
   Conclusion: This demonstrates that consuming RA for 4 wk improves serum lipids, liver enzymes, and basal inflammation in s. c. adipose tissue, but it mediates an acute pro-inflammatory response in adipose tissue upon consuming a meal.
C1 [Kruse, Michael; von Loeffelholz, Christian; Hoffmann, Daniela; Pohlmann, Antje; Seltmann, Anne-Cathrin; Osterhoff, Martin; Hornemann, Silke; Pivovarova, Olga; Pfeiffer, Andreas F. H.] German Inst Human Nutr Potsdam Rehbrucke, Dept Clin Nutr, D-14558 Nuthetal, Germany.
   [Kruse, Michael; von Loeffelholz, Christian; Osterhoff, Martin; Hornemann, Silke; Pfeiffer, Andreas F. H.] Charite, Dept Endocrinol Diabet & Nutr, D-13353 Berlin, Germany.
   [von Loeffelholz, Christian] Jena Univ Hosp, Integrated Res & Treatment Ctr, CSCC, Jena, Germany.
   [von Loeffelholz, Christian] Jena Univ Hosp, Dept Anesthesiol & Intens Care, Jena, Germany.
   [Rohn, Sascha] Univ Hamburg, Hamburg Sch Food Sci, Inst Food Chem, Hamburg, Germany.
   [Jahreis, Gerhard] Univ Jena, Inst Nutr, Dept Nutr Physiol, Jena, Germany.
C3 Leibniz Association; Deutsches Institut fur Ernahrungsforschung
   Potsdam-Rehbrucke (DIfE); Berlin Institute of Health; Free University of
   Berlin; Humboldt University of Berlin; Charite Universitatsmedizin
   Berlin; Friedrich Schiller University of Jena; Friedrich Schiller
   University of Jena; University of Hamburg; Friedrich Schiller University
   of Jena
RP Pfeiffer, AFH (corresponding author), German Inst Human Nutr Potsdam Rehbrucke, Dept Clin Nutr, Arthur Scheunert Allee 114-116, D-14558 Nuthetal, Germany.
EM afhp@dife.de
RI Ramich, Olga/AAK-5663-2020; von Loeffelholz, Christian/AAQ-3808-2021;
   Pfeiffer, Andreas/AAJ-2311-2020; Hoffmann, Daniela/JRZ-1174-2023
OI Pfeiffer, Andreas F. H./0000-0002-6887-0016; Ramich (Pivovarova),
   Olga/0000-0002-3583-8546
FU Union zur Forderung von Oel-und Proteinpflanzen e. V., Germany; German
   Institute of Human Nutrition, Potsdam-Rehbruecke
FX We thank Andreas Wagner, Melanie Hannemann, Anja Henkel, Andrea
   Borchert, and KatrinSprengel for excellent technical assistance. This
   project has been funded in part by a grant from the Union zur Forderung
   von Oel-und Proteinpflanzen e. V., Germany, and by resources of the
   German Institute of Human Nutrition, Potsdam-Rehbruecke.
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NR 51
TC 63
Z9 66
U1 1
U2 26
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1613-4125
EI 1613-4133
J9 MOL NUTR FOOD RES
JI Mol. Nutr. Food Res.
PD MAR
PY 2015
VL 59
IS 3
BP 507
EP 519
DI 10.1002/mnfr.201400446
PG 13
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA CD0LF
UT WOS:000350763500013
PM 25403327
DA 2025-06-11
ER

PT J
AU Singer, K
   Morris, DL
   Oatmen, KE
   Wang, TY
   DelProposto, J
   Mergian, T
   Cho, KW
   Lumeng, CN
AF Singer, Kanakadurga
   Morris, David L.
   Oatmen, Kelsie E.
   Wang, Tianyi
   DelProposto, Jennifer
   Mergian, Taleen
   Cho, Kae Won
   Lumeng, Carey N.
TI Neuropeptide Y Is Produced by Adipose Tissue Macrophages and Regulates
   Obesity-Induced Inflammation
SO PLOS ONE
LA English
DT Article
ID HIGH-FAT DIET; INSULIN-RESISTANCE; METABOLIC SYNDROME; LEUKOCYTE
   SUBSETS; CHRONIC STRESS; IMMUNE-SYSTEM; WEIGHT-LOSS; LONG-TERM;
   IN-VITRO; NPY
AB Neuropeptide Y (NPY) is induced in peripheral tissues such as adipose tissue with obesity. The mechanism and function of NPY induction in fat are unclear. Given the evidence that NPY can modulate inflammation, we examined the hypothesis that NPY regulates the function of adipose tissue macrophages (ATMs) in response to dietary obesity in mice. NPY was induced by dietary obesity in the stromal vascular cells of visceral fat depots from mice. Surprisingly, the induction of Npy was limited to purified ATMs from obese mice. Significant basal production of NPY was observed in cultured bone marrow derived macrophage and dendritic cells (DCs) and was increased with LPS stimulation. In vitro, addition of NPY to myeloid cells had minimal effects on their activation profiles. NPY receptor inhibition promoted DC maturation and the production of IL-6 and TNFa suggesting an anti-inflammatory function for NPY signaling in DCs. Consistent with this, NPY injection into lean mice decreased the quantity of M1-like CD11c(+) ATMs and suppressed Ly6c(hi) monocytes. BM chimeras generated from Npy(-/-) donors demonstrated that hematopoietic NPY contributes to the obesity-induced induction of Npy in fat. In addition, loss of Npy expression from hematopoietic cells led to an increase in CD11c(+) ATMs in visceral fat with high fat diet feeding. Overall, our studies suggest that NPY is produced by a range of myeloid cells and that obesity activates the production of NPY in adipose tissue macrophages with autocrine and paracrine effects.
C1 [Singer, Kanakadurga; Morris, David L.; Oatmen, Kelsie E.; Wang, Tianyi; DelProposto, Jennifer; Mergian, Taleen; Cho, Kae Won; Lumeng, Carey N.] Univ Michigan, Sch Med, Dept Pediat & Communicable Dis, Ann Arbor, MI 48109 USA.
   [Lumeng, Carey N.] Univ Michigan, Sch Med, Dept Mol & Integrat Physiol, Ann Arbor, MI USA.
C3 University of Michigan System; University of Michigan; University of
   Michigan System; University of Michigan
RP Lumeng, CN (corresponding author), Univ Michigan, Sch Med, Dept Pediat & Communicable Dis, Ann Arbor, MI 48109 USA.
EM clumeng@umich.edu
RI ; Morris, David/J-4002-2012
OI Lumeng, Carey/0000-0003-0303-6204; Morris, David/0000-0001-7607-3829;
   Singer, Kanakadurga/0000-0001-8278-3800
FU National Institutes of Health [DK090262]; Endocrine Fellows Foundation;
   Eunice Kennedy Shriver National Institute of Child Health and Human
   Development [K12HD028820] Funding Source: NIH RePORTER; National
   Institute of Diabetes and Digestive and Kidney Diseases [R01DK090262,
   P30DK020572] Funding Source: NIH RePORTER
FX This work was funded by grants from the National Institutes of Health
   DK090262 and a grant from the Endocrine Fellows Foundation. The funders
   had no role in study design, data collection and analysis, decision to
   publish, or preparation of the manuscript.
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NR 52
TC 82
Z9 89
U1 0
U2 15
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAR 5
PY 2013
VL 8
IS 3
AR e57929
DI 10.1371/journal.pone.0057929
PG 11
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 099RC
UT WOS:000315637900063
PM 23472120
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Huang, HY
   Korivi, M
   Tsai, CH
   Yang, JH
   Tsai, YC
AF Huang, Hui-Yu
   Korivi, Mallikarjuna
   Tsai, Chun-Han
   Yang, Jo-Hsuan
   Tsai, Ying-Chieh
TI Supplementation of Lactobacillus plantarum K68 and
   Fruit-Vegetable Ferment along with High Fat-Fructose Diet Attenuates
   Metabolic Syndrome in Rats with Insulin Resistance
SO EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Article
ID NECROSIS-FACTOR-ALPHA; LACTIC-ACID BACTERIA; ANTIOXIDANT ACTIVITY;
   CHOLESTEROL LEVELS; OXIDATIVE STRESS; OBESITY; ADIPONECTIN; EXPRESSION;
   ACIDOPHILUS; DEFINITION
AB Lactobacillus plantarum K68 (isolated from fu-tsai) and fruit-vegetable ferment (FVF) have been tested for antidiabetic, anti-inflammatory, and antioxidant properties in a rat model of insulin resistance, induced by chronic high fat-fructose diet. Fifty rats were equally assigned into control (CON), high fat-fructose diet (HFFD), HFFD plus K68, HFFD plus FVF, and HFFD plus both K68 and FVF (MIX) groups. Respective groups were orally administered with K68 (1 x 10(9) CFU/0.5 mL) or FVF (180 mg/kg) or MIX for 8 weeks. We found that HFFD-induced increased bodyweights were prevented, and progressively increased fasting blood glucose and insulin levels were reversed (P < 0.01) by K68 and FVF treatments. Elevated glycated hemoglobin (HbA1c) and HOMA-IR values were controlled in supplemented groups. Furthermore, dyslipidemia, characterized by elevated total cholesterol (TC), triglyceride (TG), and low-density lipoproteins (LDLs) with HFFD, was significantly (P < 0.01) attenuated with MIX. Elevated pro-inflammatory cytokines, interleukin-1 beta (IL-1 beta), IL-6, and tumor necrosis factor-alpha (TNF-alpha), were controlled (P < 0.01) by K68, FVF, and MIX treatments. Moreover, decreased superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) activities were substantially (P < 0.01) restored by all treatments. Experimental evidences demonstrate that K68 and FVF may be effective alternative medicine to prevent HFFD-induced hyperglycemia, hyperinsulinemia, and hyperlipidemia, possibly associated with anti-inflammatory and antioxidant efficacies.
C1 [Huang, Hui-Yu; Tsai, Chun-Han; Yang, Jo-Hsuan] Shih Chien Univ, Dept Food Sci Nutr & Nutraceut Biotechnol, Taipei 10462, Taiwan.
   [Korivi, Mallikarjuna] Natl Hlth Res Inst, Inst Populat Hlth Sci, Div Mental Hlth & Addict Med, Zhunan 35053, Taiwan.
   [Korivi, Mallikarjuna] TPEC, Dept Sports Sci, Taipei 11153, Taiwan.
   [Tsai, Ying-Chieh] Natl Yang Ming Univ, Inst Biochem & Mol Biol, Taipei 11221, Taiwan.
C3 Shih Chien University; National Health Research Institutes - Taiwan;
   University of Taipei; Taipei Physical Education College; National Yang
   Ming Chiao Tung University
RP Huang, HY (corresponding author), Shih Chien Univ, Dept Food Sci Nutr & Nutraceut Biotechnol, Taipei 10462, Taiwan.
EM maggieh@mail.usc.edu.tw; tsaiyc@ym.edu.tw
RI lai, xingfei/IYJ-6251-2023; Korivi, Mallikarjuna/C-7952-2012
OI Korivi, Mallikarjuna/0000-0002-4038-1368
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NR 47
TC 38
Z9 44
U1 0
U2 30
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1741-427X
EI 1741-4288
J9 EVID-BASED COMPL ALT
JI Evid.-based Complement Altern. Med.
PY 2013
VL 2013
AR 943020
DI 10.1155/2013/943020
PG 12
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA 132UF
UT WOS:000318093500001
PM 23690866
OA Green Submitted, gold, Green Published
DA 2025-06-11
ER

PT J
AU Endo, K
   Oyama, T
   Saiki, A
   Ban, N
   Ohira, M
   Koide, N
   Murano, T
   Watanabe, H
   Nishii, M
   Miura, M
   Sekine, K
   Miyashita, Y
   Shirai, K
AF Endo, Kei
   Oyama, Tomokazu
   Saiki, Atsuhito
   Ban, Noriko
   Ohira, Masahiro
   Koide, Nobukiyo
   Murano, Takeyoshi
   Watanabe, Hitoshi
   Nishii, Manabu
   Miura, Minoru
   Sekine, Kyoichi
   Miyashita, Yoh
   Shirai, Koji
TI Determination of serum 7-ketocholesterol concentrations and their
   relationships with coronary multiple risks in diabetes mellitus
SO DIABETES RESEARCH AND CLINICAL PRACTICE
LA English
DT Article
DE type 2 diabetes mellitus; serum 7-ketocholesterol; metabolic syndrome;
   LDL-C; insulin resistance
ID CHOLESTEROL OXIDATION-PRODUCTS; LOW-DENSITY LIPOPROTEINS; VITAMIN-E;
   STRESS; COMPLICATIONS; RESISTANCE; OXIDES
AB Oxysterols have cytotoxic effects and contribute to the development of atherosclerosis. To examine association between 7-ketocholesterol and diabetes mellitus, and other coronary risk factors, we developed a reliable quantitative method to measure serum 7-ketocholesterol (s-7KCHO) and studied s-7KCHO in patients with type 2 diabetes mellitus (T2DM). The s-7KCHO was detected by gas chromatography-mass spectrometry assay. The s-7KCHO was significantly higher in patients with T2DM (n = 137, 33.8 ng/ml) compared to non-diabetic healthy subjects (n = 89,16.1 ng/ml). Patients with T2DM were divided into two groups with two or more than two risk factors (defined as multiple risk factors group) and with zero or one risk factor (non-multiple risk factors group). The s-7KCHO was significantly higher in multiple risk factors group (39.5 ng/ml) compared to non-multiple risk factors (30.1 ng/ml). Among patients with multiple risk factors group, s-7KCHO was significantly higher in patients with high low-density lipoprotein cholesterol (LDL-C) levels (45.1 +/- 5.9 ng/ml) compared to those with normal LDL-C levels (35.3 +/- 7.0 ng/ml). Furthermore, s-7KCHO increased according to the number of concurrent coronary risk factors. These results suggest that serum 7-ketocholesterol levels may depend on the multiple risk factors and serum LDL-C levels. (c) 2007 Elsevier Ireland Ltd. All rights reserved.
C1 [Endo, Kei; Oyama, Tomokazu; Saiki, Atsuhito; Ban, Noriko; Ohira, Masahiro; Koide, Nobukiyo] Toho Univ, Med Ctr, Sakura Hosp, Ctr Diabet Endocrionol & Metab, Sakura, Chiba 2850841, Japan.
   [Miyashita, Yoh; Shirai, Koji] Toho Univ, Med Ctr, Sakura Hosp, Dept Internal Med, Sakura, Chiba 2850841, Japan.
   [Murano, Takeyoshi; Watanabe, Hitoshi] Toho Univ, Med Ctr, Sakura Hosp, Clin Lab Med, Sakura, Chiba 2850841, Japan.
   [Nishii, Manabu; Miura, Minoru; Sekine, Kyoichi] Mitsubishi Kagaku Biochem Labs Inc, Dept Res & Dev, Tokyo, Japan.
C3 Toho University; Toho University; Toho University
RP Miyashita, Y (corresponding author), Toho Univ, Med Ctr, Sakura Hosp, Ctr Diabet Endocrionol & Metab, 564-1 Shimoshizu, Sakura, Chiba 2850841, Japan.
EM mumon@sf6.so-net.ne.jp
OI Ohira, Masahiro/0000-0002-1935-6125
CR [Anonymous], FREE RADICALS LIPOPR
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NR 30
TC 38
Z9 41
U1 0
U2 0
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0168-8227
EI 1872-8227
J9 DIABETES RES CLIN PR
JI Diabetes Res. Clin. Pract.
PD APR
PY 2008
VL 80
IS 1
BP 63
EP 68
DI 10.1016/j.diabres.2007.10.023
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 294SM
UT WOS:000255425900010
PM 18207277
DA 2025-06-11
ER

PT J
AU Ikejima, K
   Okumura, K
   Kon, K
   Takei, Y
   Sato, N
AF Ikejima, Kenichi
   Okumura, Kyoko
   Kon, Kazuyoshi
   Takei, Yoshiyuki
   Sato, Nobuhiro
TI Role of adipocytokines in hepatic fibrogenesis
SO JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
LA English
DT Article; Proceedings Paper
CT International Symposium on Energy Metabolism and Oxidative Stress in
   Liver Pathophysiology
CY DEC 16-17, 2005
CL Tokyo, JAPAN
DE adiponectin; leptin; liver fibrosis; non-alcoholic steatohepatitis
   (NASH); oxidative stress
ID NONALCOHOLIC FATTY LIVER; STELLATE CELLS; INSULIN-RESISTANCE;
   SCHISTOSOMA-MANSONI; METABOLIC SYNDROME; MURINE LIVER; OBESE MICE;
   LEPTIN; STEATOHEPATITIS; FIBROSIS
AB Obesity and insulin resistance are the key factors for progression of hepatic fibrosis in various chronic liver diseases including non-alcoholic steatohepatitis (NASH). Recently it has been shown that leptin plays a pivotal role in development of hepatic fibrosis. Leptin promotes hepatic fibrogenesis through upregulation of transforming growth factor-beta in Kupffer cells and sinusoidal endothelial cells. Further, leptin facilitates proliferation and prevents apoptosis of hepatic stellate cells. There is a paradox, however, in that ob/ob mice and Zucker rats, which are the obese and diabetic strains, had minimal profibrogenic responses in the liver, most likely because they lack leptin and its receptors. To establish a more clinically relevant model to study the mechanism of fibrogenesis under steatohepatitis, fatty changes and profibrogenic responses in the liver caused by methionine-choline deficiency (MCD) were investigated in the KK-A(y) mouse, which is an obese and diabetic strain. KK-A(y) mice developed more severe hepatic steatosis, inflammation and fibrosis induced by an MCD diet as compared to C57Bl/6 controls. Importantly, KK-A(y) mice lack physiological upregulation of adiponectin levels, suggesting that adiponectin plays a pivotal role not only in regulation of insulin sensitivity but also in modulation of inflammatory and profibrogenic responses in dietary steatohepatitis. Collectively, these findings support the hypothesis that the balance of adipocytokine expression is a key regulator for the progression of hepatic fibrosis in the setting of steatohepatitis.
C1 Juntendo Univ, Sch Med, Bunkyo Ku, Tokyo 1138421, Japan.
C3 Juntendo University
RP Ikejima, K (corresponding author), Juntendo Univ, Sch Med, Bunkyo Ku, 2-1-1 Hongo, Tokyo 1138421, Japan.
EM ikejima@med.juntendo.ac.jp
RI Kon, Kazuyoshi/AAV-7832-2020
OI Kon, Kazuyoshi/0000-0002-1127-2218
CR Angulo P, 2002, NEW ENGL J MED, V346, P1221, DOI 10.1038/nrdp.2015.80
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NR 30
TC 62
Z9 68
U1 0
U2 7
PU BLACKWELL PUBLISHING
PI OXFORD
PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND
SN 0815-9319
J9 J GASTROEN HEPATOL
JI J. Gastroenterol. Hepatol.
PD JUN
PY 2007
VL 22
SU 1
BP S87
EP S92
DI 10.1111/j.1440-1746.2007.04961.x
PG 6
WC Gastroenterology & Hepatology
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 178FB
UT WOS:000247205500022
PM 17567476
DA 2025-06-11
ER

PT J
AU Alvarado-Tapias, E
   Pose, E
   Gratacós-Ginès, J
   Clemente-Sánchez, A
   López-Pelayo, H
   Bataller, R
AF Alvarado-Tapias, Edilmar
   Pose, Elisa
   Gratacos-Gines, Jordi
   Clemente-Sanchez, Ana
   Lopez-Pelayo, Hugo
   Bataller, Ramon
TI Alcohol-associated liver disease: Natural history, management and novel
   targeted therapies
SO CLINICAL AND MOLECULAR HEPATOLOGY
LA English
DT Review
DE Alcohol-associated hepatitis; Alcohol use disorder; Corticoids
ID RANDOMIZED CONTROLLED-TRIAL; GENOME-WIDE ASSOCIATION; DOUBLE-BLIND;
   METABOLIC SYNDROME; HEAVY DRINKERS; USE DISORDER; LILLE MODEL;
   HEPATITIS-C; RISK LOCI; CIRRHOSIS
AB Alcohol consumption is a leading cause of preventable morbidity and mortality worldwide and the primary cause of advanced liver disease. Alcohol use disorder is a chronic, frequently relapsing condition characterized by persistent alcohol consumption despite its negative consequences. Alcohol-associated liver disease (ALD) encompasses a series of stages, from fatty liver (steatosis) to inflammation (steatohepatitis), fibrosis, and, ultimately, liver cirrhosis and its complications. The development of ALD is complex, involving both genetic and environmental factors, yet the exact mechanisms at play remain unclear. Alcohol-associated hepatitis (AH), a severe form of ALD, presents with sudden jaundice and liver failure. Currently, there are no approved targeted therapies able to interfere in the pathogenesis of ALD to stop the progression of the disease, making alcohol abstinence the most effective way to improve prognosis across all stages of ALD. For patients with advanced ALD who do not respond to medical therapy, liver transplantation is the only option that can improve prognosis. Recently, AH has become an early indication for liver transplantation in non-responders to medical treatment, showing promising results in carefully selected patients. This review provides an update on the epidemiology, natural history, pathogenesis, and current treatments for ALD. A deeper insight into novel targeted therapies investigated for AH focusing on new pathophysiologically-based agents is also discussed, including anti-inflammatory and antioxidative stress drugs, gut-liver axis modulators, and hepatocyte regenerative molecules. (Clin Mol Hepatol 2025;31(Suppl):S112-S133)
C1 [Alvarado-Tapias, Edilmar] Autonomus Univ Barcelona, Hosp Santa Creu & St Pau, Dept Gastroenterol & Hepatol, Barcelona, Spain.
   [Alvarado-Tapias, Edilmar; Pose, Elisa; Gratacos-Gines, Jordi; Clemente-Sanchez, Ana; Bataller, Ramon] Ctr Biomed Res Liver & Digest Dis Network CIBERehd, Madrid, Spain.
   [Pose, Elisa; Gratacos-Gines, Jordi; Bataller, Ramon] Hosp Clin Barcelona, Inst Invest Biomed August Pi iSunyer IDIBAPS, Liver Unit, Villarroel 170, Barcelona 0836, Catalonia, Spain.
   [Clemente-Sanchez, Ana] Hosp Gen Univ Gregorio Maranon IiSGM, Dept Gastroenterol & Hepatol, Madrid, Spain.
   [Lopez-Pelayo, Hugo] Hosp Clin Barcelona, Psychiat & Psychol Serv, Addict Unit, ICN, Barcelona, Spain.
   [Lopez-Pelayo, Hugo] IDIBAPS, Hlth & Addict Res Grp, Barcelona, Spain.
C3 Hospital of Santa Creu i Sant Pau; Autonomous University of Barcelona;
   University of Barcelona; Hospital Clinic de Barcelona; University of
   Barcelona; Hospital Clinic de Barcelona; University of Barcelona;
   Hospital Clinic de Barcelona; IDIBAPS
RP Bataller, R (corresponding author), Hosp Clin Barcelona, Inst Invest Biomed August Pi iSunyer IDIBAPS, Liver Unit, Villarroel 170, Barcelona 0836, Catalonia, Spain.
EM bataller@clinic.cat
RI Pose, Elisa/AAE-1743-2022; Alvarado-Tapias, EDILMAR/GRJ-5472-2022;
   López-Pelayo, Hugo/AFM-9786-2022
OI Bataller, Ramon/0000-0002-1119-7799; Gratacos Gines,
   Jordi/0000-0003-1181-7238; Lopez-Pelayo, Hugo/0000-0002-3850-8374
FU gica en Salud; Joan Rodes award from the Instituto de Salud Carlos III
   [JR23/00080, RD21/0009/0010]; Carlos III Institute; European Regional
   Development Fund
FX Ramon Bataller is a recipient of NIA AA grants U01AA021908 and
   U01AA020821 from Instituto de Salud Carlos III (PI24/1984) . Edilmar
   Alvarado-Tapias is a recipient of a Joan Rodes award from the Instituto
   de Salud Carlos III (JR20/00047) and the PI21/01995 grant from the
   Instituto de Salud Carlos III-Fondos Feder. Elisa Pose is a recipient of
   an Instituto de Salud Carlos III grant PI22/00910. Jordi Gratacos-Gines
   is supported by a Rio Hortega grant, Instituto de Salud Carlos
   III-Accion Estrategica en Salud, 2021. Ana Clemente-Sanchez is a
   recipient of a Joan Rodes award from the Instituto de Salud Carlos III
   (JR23/00080) . Hugo Lopez-Pelayo is a recipient of Red de Investigacion
   en Atencion Primaria de Adicciones, (RIAPAd (RICORS) ) , which is a
   project (RD21/0009/0010) funded by the Carlos III Institute, the
   European Regional Development Fund, and the Recovery, Transformation,
   and Resilience Plan.r gica en Salud, 2021. Ana Clemente-Sanchez is a
   recipient of a Joan Rodes award from the Instituto de Salud Carlos III
   (JR23/00080) . Hugo Lopez-Pelayo is a recipient of Red de Investigacion
   en Atencion Primaria de Adicciones, (RIAPAd (RICORS) ) , which is a
   project (RD21/0009/0010) funded by the Carlos III Institute, the
   European Regional Development Fund, and the Recovery, Transformation,
   and Resilience Plan.
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NR 180
TC 2
Z9 2
U1 3
U2 4
PU KOREAN ASSOC STUDY LIVER
PI SEOUL
PA RM A1210, 53 MAPO-DAERO, MAPOTRAPALACE, DOWHA-DONG, MAPO-GU, SEOUL,
   04158, SOUTH KOREA
SN 2287-2728
EI 2287-285X
J9 CLIN MOL HEPATOL
JI Clin. Mol. Hepatol.
PD FEB
PY 2025
VL 31
SU S
DI 10.3350/cmh.2024.0709
PG 364
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 1MO9F
UT WOS:001468597800006
PM 39481875
OA gold
DA 2025-06-11
ER

PT J
AU Bayram, SS
AF Bayram, Suemeyra Sahin
TI A Narrative Review of the Significance of Popular Diets in Diabetes
   Mellitus Management
SO CUREUS JOURNAL OF MEDICAL SCIENCE
LA English
DT Review
DE high-protein diets; low-fat diets; paleolithic diet; gluten-free diet;
   intermittent fasting; ketogenic diets; plant-based diets; popular diets;
   diabetes mellitus
ID GLUTEN-FREE DIET; CARBOHYDRATE KETOGENIC DIET; CARDIOVASCULAR-DISEASE
   RISK; HIGH-PROTEIN DIETS; MEDITERRANEAN DIET; METABOLIC SYNDROME;
   NUTRITION THERAPY; OXIDATIVE STRESS; BLOOD-PRESSURE; NORDIC DIET
AB Diabetes mellitus is a collection of metabolic disorders marked by elevated levels of glucose in the blood due to irregularities in the generation or functioning of insulin. Medical nutrition therapy and weight loss are crucial elements in the management of diabetes and the prevention of complications. Several diets have become popular over time for the goal of achieving weight loss, but their popularity has declined due to a lack of reliable scientific evidence. This study classifies popular diets into three categories: diets that manage the composition of macronutrients, diets that restrict specific foods or food groups, and diets that manipulate meal timing. The review includes research studies that investigated the effects of popular diets on the prevention, management, and complications of diabetes. It is clear that different popular diets can have positive effects on both preventing and treating diabetes and preventing and treating complications related to diabetes. However, it is not practical to determine which diet is the most effective option for preventing or controlling diabetes. Thus, the main focus should be on common underlying factors that support well-being, such as decreasing the intake of refined grains and added sugar, choosing non -starchy vegetables, and giving priority to whole foods over processed foods whenever possible, until there is stronger evidence supporting the specific benefits of different dietary patterns.
C1 [Bayram, Suemeyra Sahin] Selcuk Univ, Nutr & Dietet, Konya, Turkiye.
C3 Selcuk University
RP Bayram, SS (corresponding author), Selcuk Univ, Nutr & Dietet, Konya, Turkiye.
EM susahin@selcuk.edu.tr
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NR 116
TC 0
Z9 0
U1 4
U2 8
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
EI 2168-8184
J9 CUREUS J MED SCIENCE
JI Cureus J Med Sci
PD MAY 25
PY 2024
VL 16
IS 5
AR e61045
DI 10.7759/cureus.61045
PG 13
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA US5N8
UT WOS:001250061600003
PM 38800782
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Bird, JK
   Feskens, EJM
   Melse-Boonstra, A
AF Bird, Julia K.
   Feskens, Edith J. M.
   Melse-Boonstra, Alida
TI A Systematized Review of the Relationship Between Obesity and Vitamin C
   Requirements
SO CURRENT DEVELOPMENTS IN NUTRITION
LA English
DT Review
DE vitamin C; obesity; vitamin requirements; vitamin status; vitamin intake
ID ASCORBIC-ACID; METABOLIC SYNDROME; OXIDATIVE STRESS; DIETARY FACTORS;
   PLASMA; RISK; CONSUMPTION; NUTRITION; HEALTHY; DISEASE
AB Obesity rates have increased globally in recent decades. Body weight is used as a modifiable factor in determining vitamin requirements. Accordingly, vitamin C requirements are volumetrically scaled from data for healthy weight males to other age- and sex-based categories. Likewise, it is possible that increases in body weight due to obesity may affect vitamin C needs. A systematized literature review was performed to summarize evidence on whether obesity affects vitamin C intake or status. The literature was also scanned for potential mechanisms for the relationship. Many observational studies showed that vitamin C status is lower in overweight and obese children and adults; this may be explained by lower vitamin C intakes. Nevertheless, a reanalysis of carefully conducted intervention studies has demonstrated a lower vitamin C status in participants who were overweight or obese when given the same dose of vitamin C as subjects of normal weight. Several mechanisms have been proposed to potentially explain why vitamin C status is lower in people with obesity: changes in vitamin C partitioning between lean and adipose tissue, volumetric dilution, metabolic alterations due to obesity, and gut microbial dysbiosis. Depletion-repletion or pharmacokinetic studies that include individuals of diverse body weights and ages would be helpful to further investigate whether obesity increases requirements for vitamin C. The current evidence base supports a lower vitamin C status in people who are overweight or obese; however, the association may be attenuated by lower vitamin C intakes.
C1 [Bird, Julia K.; Feskens, Edith J. M.; Melse-Boonstra, Alida] Wageningen Univ & Res, Div Human Nutr & Hlth, Wageningen, Netherlands.
C3 Wageningen University & Research
RP Bird, JK (corresponding author), Wageningen Univ & Res, Div Human Nutr & Hlth, Wageningen, Netherlands.
EM julia.bird@wur.nl
RI Feskens, Edith/ABI-1446-2020; Bird, Julia/I-3044-2019; Melse,
   Alida/AAH-2446-2019
OI Bird, Julia/0000-0001-6015-3576
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NR 89
TC 3
Z9 3
U1 4
U2 11
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 2475-2991
J9 CURR DEV NUTR
JI Curr. Dev. Nutr.
PD MAY
PY 2024
VL 8
IS 5
AR 102152
DI 10.1016/j.cdnut.2024.102152
EA APR 2024
PG 14
WC Nutrition & Dietetics
WE Emerging Sources Citation Index (ESCI)
SC Nutrition & Dietetics
GA C8E4Q
UT WOS:001291645000001
PM 38666038
OA gold
DA 2025-06-11
ER

PT J
AU Decker, NS
   Johnson, T
   Le Cornet, C
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AF Decker, Nina Sophia
   Johnson, Theron
   Le Cornet, Charlotte
   Behrens, Sabine
   Obi, Nadia
   Kaaks, Rudolf
   Chang-Claude, Jenny
   Fortner, Renee Turzanski
TI Associations between lifestyle, health, and clinical characteristics and
   circulating oxysterols and cholesterol precursors in women diagnosed
   with breast cancer: a cross-sectional study
SO SCIENTIFIC REPORTS
LA English
DT Article
ID FAMILIAL COMBINED HYPERLIPIDEMIA; METABOLIC SYNDROME; OXIDATIVE STRESS;
   HUMAN PLASMA; 27-HYDROXYCHOLESTEROL; MARKERS; OBESITY; RISK
AB Despite increasing evidence that cholesterol precursors and oxysterols, oxidized cholesterol metabolites, play a role in numerous pathological processes and diseases including breast cancer, little is known about correlates of these sterols in women with breast cancer. In this study, 2282 women with breast cancer and blood draw post diagnosis were included and cross-sectional associations between circulating levels of 15 sterols/oxysterols and (a) lifestyle, anthropometric, reproductive characteristics, (b) comorbidities and medication use, and (c) breast cancer tumor and treatment characteristics were calculated using generalized linear models. Obesity was strongly associated with circulating levels of 7-dehydrocholesterol (DC) (body mass index >= 30 vs. 18.5-24.9 kg/m2: 51.7% difference) and 7-ketocholesterol (KC) (40.0% difference). After adjustment for BMI, comorbidities such as cardiovascular disease were associated with higher levels of 7-DC (26.1% difference) and lower levels of desmosterol (- 16.4% difference). Breast cancer tumor characteristics including hormone receptor status, tumor stage, and endocrine therapy were associated with lanosterol, 24-DHLan, 7b-HC, and THC (e.g., THC; tumor stage IIIa vs. I: 36.9% difference). Weaker associations were observed for lifestyle characteristics and for any of the other oxysterols. The findings of this study suggest that cholesterol precursors are strongly associated with metabolic factors, while oxysterols are associated with breast cancer tumor characteristics, warranting further investigation into the role of cholesterol precursors and oxysterols in women with breast cancer and other populations.
C1 [Decker, Nina Sophia; Johnson, Theron; Le Cornet, Charlotte; Behrens, Sabine; Kaaks, Rudolf; Chang-Claude, Jenny; Fortner, Renee Turzanski] German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany.
   [Decker, Nina Sophia] Heidelberg Univ, Med Fac Heidelberg, Heidelberg, Germany.
   [Obi, Nadia] Univ Med Ctr Hamburg Eppendorf, Inst Med Biometry & Epidemiol, Hamburg, Germany.
   [Obi, Nadia] Univ Med Ctr Hamburg Eppendorf, Inst Occupat & Maritime Med Hamburg, Hamburg, Germany.
   [Chang-Claude, Jenny] Univ Canc Ctr Hamburg, Med Ctr Hamburg Eppendorf, Hamburg, Germany.
   [Fortner, Renee Turzanski] Norwegian Inst Publ Hlth, Dept Res, Canc Registry Norway, Oslo, Norway.
C3 Helmholtz Association; German Cancer Research Center (DKFZ); Ruprecht
   Karls University Heidelberg; University of Hamburg; University Medical
   Center Hamburg-Eppendorf; University of Hamburg; University Medical
   Center Hamburg-Eppendorf; University of Hamburg; University Medical
   Center Hamburg-Eppendorf; Norwegian Institute of Public Health (NIPH);
   University of Oslo
RP Fortner, RT (corresponding author), German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany.; Fortner, RT (corresponding author), Norwegian Inst Publ Hlth, Dept Res, Canc Registry Norway, Oslo, Norway.
EM rtfo@kreftregisteret.no
RI Turzanski Fortner, Renée/KMX-9538-2024
FU U.S. Army Medical Research and Material Command Fort Detrick, Maryland
   21702-5012 [70-2892-BR I, 108419, 108253, 110826, 110828]; German Cancer
   Aid (Deutsche Krebshilfe e.V.); German Cancer Research Center (DKFZ)
FX We are grateful to all the MARIE study participants for their
   contribution and the interviewers who collected the data. We thank
   Muhabbet Celik for sample preparation and sample coordination, and the
   biocrates service lab team for their expert advice in interpreting the
   oxysterol data. We express gratitude to Dieter Flesch-Janys for his
   invaluable contributions to the MARIE projects as former PI of the
   Hamburg study region. The MARIE study was funded by the German Cancer
   Aid (Deutsche Krebshilfe e.V.; Grant numbers 70-2892-BR I, 108419 and
   108253, 110826 and 110828), and the German Cancer Research Center
   (DKFZ).
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NR 45
TC 1
Z9 1
U1 0
U2 0
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD FEB 29
PY 2024
VL 14
IS 1
AR 4977
DI 10.1038/s41598-024-55316-x
PG 16
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA KI0D4
UT WOS:001179204200046
PM 38424253
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Costa, P
   Rosa, GM
   Testino, G
   Dorighi, U
   Porto, I
AF Costa, Paolo
   Rosa, Gian M.
   Testino, Gianni
   Dorighi, Ulrico
   Porto, Italo
TI Liver involvement in presence of heart disease and heart involvement in
   presence of liver disease: a conundrum
SO MINERVA GASTROENTEROLOGY
LA English
DT Article
DE Liver diseases; Heart failure; Cardiomyopathies; Alcoholism
ID CIRRHOTIC CARDIOMYOPATHY; HYPOXIC HEPATITIS; DIASTOLIC DYSFUNCTION;
   TAKOTSUBO CARDIOMYOPATHY; CARDIOVASCULAR-DISEASES; CARDIAC HEPATOPATHY;
   ALCOHOL-CONSUMPTION; METABOLIC SYNDROME; OXIDATIVE STRESS; NITRIC-OXIDE
AB Data from literature show a cross -talk between the heart and liver during diseases which primarily involve one of the two organs, but data regarding this relationship are scant. Aim of this study was to investigate this relationship. In this narrative review we critically explored the most recent literature on this topic using PubMed and Medline and examining the most recent studies about liver involvement in heart failure and heart involvement in course of liver disease. Patients with acute and chronic heart failure and those who undergo heart transplatation (HT) manifest various signs of liver damage with a rate of incidence which is higher in candidates for left ventricular assist device. In presence of cardiogenic shock a very marked hepatocellular necrosis may occur while in the setting of chronic heart failure congestive hepatopathy andor the so-called cardiac cirrhosis are observed. On the other side in presence of chronic liver disease and in case of liver transplantation (LT) heart functions may be altered and cirrhotic cardiomyopathy, which is a syndrome characterized by systolic, diastolic and electrophysiological abnormalities may occur. In this review we have analyzed the relationship between heart and liver disease, even in case of LT and HT. Furthermore we have underscored the effects of chronic alcoholism and of systemic disorders such as hemochromatosis and amyloidosis on both heart and liver.
C1 [Costa, Paolo; Rosa, Gian M.; Porto, Italo] Univ Genoa, Dept Internal Med DIMI, Clin Cardiovasc Dis, Genoa, Italy.
   [Rosa, Gian M.; Dorighi, Ulrico; Porto, Italo] Polyclin Hosp, IRCCS San Martino, Largo R Benzi 10, I-16132 Genoa, Italy.
   [Testino, Gianni] IRCCS San Martino Polyclin Hosp Genoa, Alcohol Reg Ctr, Unit Addict & Hepatol, Genoa, Italy.
C3 University of Genoa; University of Genoa; IRCCS AOU San Martino IST
RP Rosa, GM (corresponding author), Polyclin Hosp, IRCCS San Martino, Largo R Benzi 10, I-16132 Genoa, Italy.
EM gmrosa@libero.it
RI Porto, Italo/V-5801-2019
OI Porto, Italo/0000-0002-9854-5046; Costa, Paolo/0000-0001-6841-9375
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NR 112
TC 0
Z9 0
U1 0
U2 6
PU EDIZIONI MINERVA MEDICA
PI TURIN
PA CORSO BRAMANTE 83-85 INT JOURNALS DEPT., 10126 TURIN, ITALY
SN 2724-5985
EI 2724-5365
J9 MINERVA GASTROENTERO
JI Minerva Gastroenterol.
PD SEP
PY 2024
VL 70
IS 3
BP 359
EP 373
DI 10.23736/S2724-5985.23.03589-1
EA JAN 2024
PG 15
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA E6L0B
UT WOS:001152458100001
PM 38264884
DA 2025-06-11
ER

PT J
AU Hasimun, P
   Damayanti, EP
   Sulaeman, A
AF Hasimun, Patonah
   Damayanti, Erinna Putri
   Sulaeman, Agus
TI Potential Role of Centella asiatica and Sauropus
   androgynus in High-Fat and High-Fructose Diet-Induced-Obesity Animal
   Model
SO INDONESIAN JOURNAL OF PHARMACY
LA English
DT Article
DE Centella asiatica; Obesity; Sauropus androgynus; Triglycerides
ID TRIGLYCERIDE SYNTHESIS; OXIDATIVE STRESS; WEIGHT-GAIN; BODY-WEIGHT;
   RESISTANCE; ORLISTAT
AB Obesity is a condition characterized by excessive fat accumulation, leading to metabolic syndrome diseases including hyperglycemia, hyperlipidemia, hyperuricemia, and hypertension. Efforts to reduce obesity can minimize the risk of the disease. Therefore, this study aimed to determine the antiobesity activity of Sauropus androgynus L. Merr (SA) and Centella asiatica L.Urban (CA) combination in Swiss Webster obese mice model. A total of 36 mice were randomly grouped into six groups, including the control (receiving drug carriers), positive (receiving drug carriers), and standard (receiving orlistat 15.6 mg/kg BW). A total of three groups received a combination of SA & CA with a dosage ratio of SA:CA namely 25:25 mg/kg BW, 25:50 mg/kg BW, and 50:25 mg/kg. All groups except the normal were induced with obesity using a high -fat and high-fructose (HFHF) diet for 28 days. Subsequently, body weight, feed, feces, organ, fat index, as well as serum triglyceride levels, and percent inhibition of lipid peroxidation using malondialdehyde (MDA) absorbance were measured. The results showed that there were significant differences in parameters of body weight, feed, feces, organ, fat index, serum triglyceride level, lipid-peroxidation inhibition, and histology of adipocytes between groups of animals treated with the combination extract compared to the positive control (p<0.05). Therefore, it was concluded that the combination of SA and CA had antiobesity activity.
C1 [Hasimun, Patonah; Damayanti, Erinna Putri; Sulaeman, Agus] Bhakti Kencana Univ, Fac Pharm, Jl Soekarno Hatta 75, Bandung, Jawa Barat, Indonesia.
RP Hasimun, P (corresponding author), Bhakti Kencana Univ, Fac Pharm, Jl Soekarno Hatta 75, Bandung, Jawa Barat, Indonesia.
EM patonah@bku.ac.id
RI Sulaeman, Agus/AAD-1142-2021; Hasimun, Patonah/AAC-1216-2021
FU Bhakti Kencana University, Research and Community Service Institute
   (LPPM UBK)
FX The authors are grateful to Bhakti Kencana University, Research and
   Community Service Institute (LPPM UBK) , for the support.
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NR 30
TC 1
Z9 1
U1 0
U2 1
PU UNIV GADJAH MADA, FAC FARMASI
PI YOGYAKARTA
PA N SEKIP, YOGYAKARTA, 55281, INDONESIA
SN 2338-9486
EI 2338-9427
J9 INDONES J PHARM
JI Indones. J. Pharm.
PY 2024
VL 35
IS 2
BP 272
EP 281
PG 10
WC Pharmacology & Pharmacy
WE Emerging Sources Citation Index (ESCI)
SC Pharmacology & Pharmacy
GA TZ7F9
UT WOS:001245140000008
OA gold
DA 2025-06-11
ER

PT J
AU Santos-Cruz, LF
   Sigrist-Flores, SC
   Castañeda-Partida, L
   Heres-Pulido, ME
   Dueñas-García, IE
   Piedra-Ibarra, E
   Ponciano-Gómez, A
   Jiménez-Flores, R
   Campos-Aguilar, M
AF Santos-Cruz, Luis Felipe
   Sigrist-Flores, Santiago Cristobal
   Castaneda-Partida, Laura
   Heres-Pulido, Maria Eugenia
   Duenas-Garcia, Irma Elena
   Piedra-Ibarra, Elias
   Ponciano-Gomez, Alberto
   Jimenez-Flores, Rafael
   Campos-Aguilar, Myriam
TI Effects of Fructose and Palmitic Acid on Gene Expression in
   Drosophila melanogaster Larvae: Implications for
   Neurodegenerative Diseases
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE Drosophila melanogaster; human disease model; neurodegeneration;
   metabolic syndrome; fructose; palmitic acid
ID GLOBAL NUTRITION TRANSITION; HIGH-FAT; HIGH-SUGAR; OBESITY; SYSTEM;
   LIFE; TYROSINE; WESTERN; STRESS; FOODS
AB One of the largest health problems worldwide is the development of chronic noncommunicable diseases due to the consumption of hypercaloric diets. Among the most common alterations are cardiovascular diseases, and a high correlation between overnutrition and neurodegenerative diseases has also been found. The urgency in the study of specific damage to tissues such as the brain and intestine led us to use Drosophila melanogaster to study the metabolic effects caused by the consumption of fructose and palmitic acid in specific tissues. Thus, third instar larvae (96 & PLUSMN; 4 h) of the wild Canton-S strain of D. melanogaster were used to perform transcriptomic profiling in brain and midgut tissues to test for the potential metabolic effects of a diet supplemented with fructose and palmitic acid. Our data infer that this diet can alter the biosynthesis of proteins at the mRNA level that participate in the synthesis of amino acids, as well as fundamental enzymes for the dopaminergic and GABAergic systems in the midgut and brain. These also demonstrated alterations in the tissues of flies that may help explain the development of various reported human diseases associated with the consumption of fructose and palmitic acid in humans. These studies will not only help to better understand the mechanisms by which the consumption of these alimentary products is related to the development of neuronal diseases but may also contribute to the prevention of these conditions.
C1 [Santos-Cruz, Luis Felipe; Castaneda-Partida, Laura; Heres-Pulido, Maria Eugenia; Duenas-Garcia, Irma Elena] Univ Nacl Autonoma Mexico, Fac Estudios Superiores Iztacala, Toxicol Genet, Barrios N1, Tlalnepantla 54090, Mexico.
   [Sigrist-Flores, Santiago Cristobal; Ponciano-Gomez, Alberto; Jimenez-Flores, Rafael; Campos-Aguilar, Myriam] Univ Nacl Autonoma Mexico, Fac Estudios Superiores Iztacala, Lab Inmunol UMF, Barrios N1, Tlalnepantla 54090, Mexico.
   [Piedra-Ibarra, Elias] Univ Nacl Autonoma Mexico, Fac Estudios Super Iztacala, Fisiol Vegetal UBIPRO, Barrios N1, Tlalnepantla 54090, Mexico.
C3 Universidad Nacional Autonoma de Mexico; Universidad Nacional Autonoma
   de Mexico; Universidad Nacional Autonoma de Mexico
RP Campos-Aguilar, M (corresponding author), Univ Nacl Autonoma Mexico, Fac Estudios Superiores Iztacala, Lab Inmunol UMF, Barrios N1, Tlalnepantla 54090, Mexico.
EM neladiaem@gmail.com; santiago_sigrist@iztacala.unam.mx;
   quirros@gmail.com; eugeniaheres@hotmail.com; iduenasg@gmail.com;
   elias_piedra_ibarra@hotmail.com; alberto_ponciano@comunidad.unam.mx;
   jrjf@unam.mx; myriam.campos@iztacala.unam.mx
RI CASTAÑEDA-PARTIDA, LAURA/ABD-1608-2020; Jimenez-Flores,
   Rafael/B-6830-2017; Sigrist Flores, Santiago/HSG-9877-2023
OI Ponciano-Gomez, Alberto/0000-0002-1801-6575; Sigrist Flores, Santiago
   Cristobal/0000-0001-5925-1347
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NR 81
TC 2
Z9 2
U1 0
U2 6
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD JUN
PY 2023
VL 24
IS 12
AR 10279
DI 10.3390/ijms241210279
PG 14
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA K2HD0
UT WOS:001014692900001
PM 37373426
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Herhaus, B
   Conrad, R
   Petrowski, K
AF Herhaus, Benedict
   Conrad, Rupert
   Petrowski, Katja
TI Effect of a slow-paced breathing with heart rate variability biofeedback
   intervention on pro-inflammatory cytokines in individuals with panic
   disorder- A randomized controlled trial
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Immune system; Heart rate variability; Biofeedback; Slow-paced
   breathing; Panic disorder; Randomized controlled trial
ID STIMULATION; PHYSIOLOGY; DISEASE; STRESS
AB A generalized proinflammatory state has been observed in individuals with panic disorder (PD). There is evi-dence that slow-paced breathing (SPB) with heart rate variability-biofeedback (HRV-BF) strengthens the nervus vagus with its anti-inflammatory pathway. Therefore, with this randomized controlled trial we aimed to investigate the effect of a four-week SPB with HRV-BF intervention on pro-inflammatory cytokines in people with PD. Fifty-five individuals with PD (mean age: 37.22 +/- 15.13 years) were randomly allocated either to SPB-HRV-BF (intervention group) or to HRV-Sham-BF (active control group). SPB-HRV-BF was performed over four weeks while cytokine concentration and HRV during a short-term resting condition were measured before and after intervention. SPB-HRV-BF decreased concentration of Tumor Necrosis Factor alpha (TNF-alpha) (F (1, 53) = 4.396, p <= .05, eta 2 = 0.077) in individuals with PD. In addition, SPB-HRV-BF demonstrated an increase in the HRV-time and frequency domain parameters SDNN, Total Power and LF during short-term resting condition. There was no intervention effect in HRV-Sham-BF group. In conclusion, SBP-HRV-BF as a non-pharmacological treatment may reduce pro-inflammatory cytokine TNF-alpha via the cholinergic anti-inflammatory pathway in individuals with PD. Based on the generalized proinflammatory state in PD, decreasing TNF-alpha is highly beneficial to reduce risk of cardiovascular diseases and metabolic syndrome.
C1 [Herhaus, Benedict; Petrowski, Katja] Johannes Gutenberg Univ Mainz, Med Psychol & Med Sociol, Univ Med Ctr, Mainz, Germany.
   [Conrad, Rupert] Univ Hosp Bonn, Dept Psychosomat Med & Psychotherapy, Bonn, Germany.
   [Conrad, Rupert] Univ Hosp Muenster, Dept Psychosomat Med & Psychotherapy, Munster, Germany.
   [Herhaus, Benedict] Johannes Gutenberg Univ Mainz, Med Psychol & Med Sociol, Univ Med Ctr, Duesbergweg 6, D-55128 Mainz, Germany.
C3 Johannes Gutenberg University of Mainz; University of Bonn; University
   of Munster; Johannes Gutenberg University of Mainz
RP Herhaus, B (corresponding author), Johannes Gutenberg Univ Mainz, Med Psychol & Med Sociol, Univ Med Ctr, Mainz, Germany.; Herhaus, B (corresponding author), Johannes Gutenberg Univ Mainz, Med Psychol & Med Sociol, Univ Med Ctr, Duesbergweg 6, D-55128 Mainz, Germany.
EM bherhaus@uni-mainz.de; Rupert.Conrad@ukbonn.de; kpetrows@uni-mainz.de
RI Conrad, Rupert/J-8652-2017
OI Conrad, Rupert/0000-0003-3207-2677
FU DFG-project ? [286613756]
FX Source of funding This study was funded by the DFG-project ?Effect of
   biofeedback training on heart rate variability and immune response in
   patients with panic disorder? (Project-number: 286613756) .
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NR 36
TC 3
Z9 3
U1 3
U2 22
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD APR 1
PY 2023
VL 326
BP 132
EP 138
DI 10.1016/j.jad.2023.01.091
EA FEB 2023
PG 7
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA 8Z0IZ
UT WOS:000933074000001
PM 36720404
DA 2025-06-11
ER

PT J
AU Mthembu, SXH
   Mazibuko-Mbeje, SE
   Ziqubu, K
   Nyawo, TA
   Obonye, N
   Nyambuya, TM
   Nkambule, BB
   Silvestri, S
   Tiano, L
   Muller, CJF
   Dludla, PV
AF Mthembu, Sinenhlanhla X. H.
   Mazibuko-Mbeje, Sithandiwe E.
   Ziqubu, Khanyisani
   Nyawo, Thembeka A.
   Obonye, Nnini
   Nyambuya, Tawanda M.
   Nkambule, Bongani B.
   Silvestri, Sonia
   Tiano, Luca
   Muller, Christo J. F.
   V. Dludla, Phiwayinkosi
TI Impact of physical exercise and caloric restriction in patients with
   type 2 diabetes: Skeletal muscle insulin resistance and mitochondrial
   dysfunction as ideal therapeutic targets
SO LIFE SCIENCES
LA English
DT Review
DE Metabolic syndrome; Type 2 diabetes; Skeletal muscle; Insulin
   resistance; Mitochondrial function; Therapeutic interventions; Physical
   exercise; Caloric restriction
ID WEIGHT-LOSS; OBESE WOMEN; PROTEIN; SENSITIVITY; INTENSITY; ACTIVATION;
   STRESS
AB Skeletal muscle insulin resistance and mitochondrial dysfunction are some of the major pathological defects implicated in the development of type 2 diabetes (T2D). Therefore, it has become necessary to understand how common interventions such as physical exercise and caloric restriction affect metabolic function, including physiological processes that implicate skeletal muscle dysfunction within a state of T2D. This review critically discusses evidence on the impact of physical exercise and caloric restriction on markers of insulin resistance and mitochondrial dysfunction within the skeletal muscle of patients with T2D or related metabolic complications. Importantly, relevant information from clinical studies was acquired through a systematic approach targeting major electronic databases and search engines such as PubMed, Google Scholar, and Cochrane library. The reported evidence suggests that interventions like physical exercise and caloric restriction, within a duration of approximately 2 to 4 months, can improve insulin sensitivity, in part by targeting the phosphoinositide 3-kinases/protein kinase B pathway in patients with T2D. Furthermore, both physical exercise and caloric restriction can effectively modulate markers related to improved mitochondrial function and dynamics. This was consistent with an improved modulation of mitochondrial oxidative capacity and reduced production of reactive oxygen species in patients with T2D or related metabolic complications. However, such conclusions are based on limited evidence, additional clinical trials are required to better understand these interventions on pathological mechanisms of T2D and related abnormalities.
C1 [Mthembu, Sinenhlanhla X. H.; Nyawo, Thembeka A.; Obonye, Nnini; Muller, Christo J. F.; V. Dludla, Phiwayinkosi] South African Med Res Council, Biomed Res & Innovat Platform, ZA-7505 Tygerberg, South Africa.
   [Mthembu, Sinenhlanhla X. H.; Mazibuko-Mbeje, Sithandiwe E.; Ziqubu, Khanyisani] North West Univ, Dept Biochem, Mafikeng Campus, ZA-2735 Mmabatho, South Africa.
   [Nyawo, Thembeka A.; Obonye, Nnini; Muller, Christo J. F.] Stellenbosch Univ, Fac Med & Hlth Sci, Div Med Physiol, Ctr Cardiometab Res Africa CARMA, ZA-7505 Tygerberg, South Africa.
   [Nyambuya, Tawanda M.] Namibia Univ Sci & Technol, Fac Hlth & Appl Sci, Dept Hlth Sci, Windhoek 9000, Namibia.
   [Nkambule, Bongani B.] Univ KwaZulu Natal, Sch Lab Med & Med Sci, Coll Hlth Sci, ZA-4000 Durban, South Africa.
   [Silvestri, Sonia; Tiano, Luca] Polytech Univ Marche, Dept Life & Environm Sci, I-60131 Ancona, Italy.
   [Muller, Christo J. F.] Univ Zululand, Dept Biochem & Microbiol, ZA-3880 Kwa Dlangezwa, South Africa.
C3 South African Medical Research Council; North West University - South
   Africa; Stellenbosch University; Namibia University of Science &
   Technology; University of Kwazulu Natal; Marche Polytechnic University;
   University of Zululand
RP Dludla, PV (corresponding author), South African Med Res Council, Biomed Res & Innovat Platform, ZA-7505 Tygerberg, South Africa.
EM pdludla@mrc.ac.za
RI Nyambuya, Tawanda Maurice/GLU-4124-2022; Nkambule,
   Bongani/ABD-7943-2022; Tiano, Luca/ABC-2341-2020; Mazibuko-Mbeje,
   Sithandiwe/HPG-1119-2023
OI MTHEMBU, SINENHLANHLA/0000-0003-2747-1841; Nyambuya, Tawanda
   Maurice/0000-0002-3288-9524; Nkambule, Bongani/0000-0001-8846-1992
FU SAMRC through Division of Research Capacity Development; South African
   National Treasury; DST-NRF Professional Development Programme (PDP)
   programme
FX S.X.H.M. and K.Z. are funded by the SAMRC through its Division of
   Research Capacity Development under the internship scholarship pro-gram
   from funding received from the South African National Treasury.
   Financial support for T.A.N., as a Ph.D. student under the DST-NRF
   Professional Development Programme (PDP) programme. Grant holders
   acknowledge that opinions, findings and conclusions or recommendations
   expressed in any publication generated by the SAMRC supported research
   are those of the authors, and that the SAMRC accepts no liability
   whatsoever in this regard.
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NR 74
TC 24
Z9 24
U1 1
U2 23
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0024-3205
EI 1879-0631
J9 LIFE SCI
JI Life Sci.
PD MAY 15
PY 2022
VL 297
AR 120467
DI 10.1016/j.lfs.2022.120467
EA MAR 2022
PG 10
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA 1C6SE
UT WOS:000793245500010
PM 35271881
DA 2025-06-11
ER

PT J
AU Zhang, SH
   Zhang, YC
   Lin, SJ
   Zhang, S
   Qiu, M
AF Zhang, Shaohong
   Zhang, Yingchai
   Lin, Shuangjie
   Zhang, Shuguang
   Qiu, Mingshan
TI Hyperuricemia as a possible risk factor for abnormal lipid metabolism in
   the Chinese population: a cross-sectional study
SO ANNALS OF PALLIATIVE MEDICINE
LA English
DT Article
DE Serum uric acid (UA); dyslipidemia; lipid profile; hyperuricemia;
   metabolic diseases
ID URIC-ACID; OXIDATIVE STRESS; SERUM-LEVELS; PROTEIN; ACCUMULATION;
   GENERATION; BEHAVIOR
AB Background: Previous studies have reported that there may be a close relationship between elevated serum uric acid (UA) levels and metabolic syndrome. However, the association between these two factors has not been explored explicitly. Therefore, we carried out this study to investigate the association between UA and lipid profiles.
   Methods: A total of 2,482 subjects participated in this cross-sectional study using a multistage stratified sampling method. Lipid profile, glucose metabolism, and other metabolic factors were measured and classified into UA-stratified and age-stratified groups to investigate the relationship between hyperuricemia and metabolic factors. Pearson correlations and logistic regressions were utilized to further explore the association between UA and lipid profile.
   Results: The individuals aged 18 to 29 years presented with high serum UA concentrations. Moreover, the prevalence of hyperuricemia was higher among men than in women. Furthermore, statistically significant positive correlations were found between UA and serum triglycerides (TG), serum total cholesterol (TC), and low-density lipoprotein cholesterol (LDL-c). Conversely, only high-density lipoprotein cholesterol (HDL-c) was negatively correlated. Moreover, TG group status (1.70 <= TG <2.30 mmol/L) was an independent risk factor for hyperuricemia in both univariate and multivariate models.
   Conclusions: This study found significant positive associations between TG, TC, LDL, and UA but an inverse relationship with HDL-c. Thus hyperuricemia may be a risk factor for abnormal lipid metabolism.
C1 [Zhang, Shaohong; Zhang, Yingchai] Nanjing Univ Chinese Med, Affiliated Hosp Integrated Tradit Chinese & Weste, Dept Endocrinol, Nanjing, Peoples R China.
   [Zhang, Shaohong] Nanjing Med Univ, Affiliated Huaian Peoples Hosp 1, Dept Geriatr, Huaian, Peoples R China.
   [Zhang, Yingchai; Zhang, Shuguang] Nanjing Univ Chinese Med, Nanjing, Peoples R China.
   [Lin, Shuangjie] Community Hlth Serv Ctr, Dept TCM, HeShan St, Xiamen, Peoples R China.
   [Zhang, Shuguang] Huaian Hosp Tradit Chinese Med, Dept Cardiol, Huaian, Peoples R China.
   [Qiu, Mingshan] Beijing Univ Chinese Med, Xiamen Hosp, Dept Rheumatol, Xiamen, Peoples R China.
   [Qiu, Mingshan] Xiamen Hosp Tradit Chinese Med, Dept Rheumatol, Xiamen, Peoples R China.
C3 Nanjing University of Chinese Medicine; Nanjing Medical University;
   Nanjing University of Chinese Medicine; Beijing University of Chinese
   Medicine
RP Zhang, S (corresponding author), Huaian Hosp Tradit Chinese Med, Huaian 223001, Peoples R China.; Qiu, M (corresponding author), Beijing Univ Chinese Med, Xiamen Hosp, Xiamen 361000, Peoples R China.
EM fsyy02123@njucm.edu.cn; qiumingshan@sohu.com
RI Zhang, Yingchai/GWQ-7268-2022
FU Practice Innovation Program of Jiangsu Province [KYCX19_1184]; Huai'an
   Science and Technology Plan (Natural Science Research Program)
   [HABZ201813]
FX This study was funded by the Practice Innovation Program of Jiangsu
   Province (KYCX19_1184) and Huai'an Science and Technology Plan (Natural
   Science Research Program, HABZ201813).
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NR 33
TC 8
Z9 12
U1 4
U2 19
PU AME PUBLISHING COMPANY
PI SHATIN
PA FLAT-RM C 16F, KINGS WING PLAZA 1, NO 3 KWAN ST, SHATIN, HONG KONG
   00000, PEOPLES R CHINA
SN 2224-5820
EI 2224-5839
J9 ANN PALLIAT MED
JI Ann. Pallliat. Med.
PD NOV
PY 2021
VL 10
IS 11
BP 11454
EP +
DI 10.21037/apm-21-2734
EA NOV 2021
PG 11
WC Health Care Sciences & Services
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Health Care Sciences & Services
GA YZ0EV
UT WOS:000722850400001
PM 34872270
OA gold
DA 2025-06-11
ER

PT J
AU Duan, X
   Liu, JB
   Mu, YZ
   Liu, T
   Chen, YJ
   Yu, RC
   Xiong, XC
   Wu, T
AF Duan, Xi
   Liu, Junbo
   Mu, Yunzhu
   Liu, Ting
   Chen, Yujuan
   Yu, Ruichao
   Xiong, Xincai
   Wu, Tao
TI A systematic review and meta-analysis of the association between
   psoriasis and hypertension with adjustment for covariates
SO MEDICINE
LA English
DT Review
DE psoriasis; hypertension; adjusted-for-covariates; meta-analysis
ID ANGIOTENSIN-CONVERTING ENZYME; CARDIOVASCULAR RISK-FACTORS; METABOLIC
   SYNDROME; MYOCARDIAL-INFARCTION; HIGH PREVALENCE; COMORBIDITIES;
   MODERATE; EVENTS; STRESS; COHORT
AB Background: Several studies have shown a relationship between psoriasis and hypertension, but no meta-analysis has been restricted to studies that adjusted for confounders. The aim of the study was to estimate the association between psoriasis and hypertension with adjustment for covariates.
   Methods: A systematic literature search in the MEDLINE, Embase, Cochrane databases, and Google Scholar was conducted to identify relevant studies which reported the association of psoriasis with the risk of hypertension published up to November 2018 in English. Data analysis was performed with Stata V.12, and Begg adjusted rank correlation test and Egger regression asymmetry test were used to detect publication bias.
   Results: A total of 16 adjusted-for-covariates studies, involving 50,291 cases with hypertension in 255,132 psoriasis patients and 76,547 cases with hypertension in 814,631 controls (no psoriasis), were included in this meta-analysis. The results indicated that psoriasis was associated with an increased risk of hypertension compared to those without psoriasis, and the prevalence of hypertension in severe psoriasis patients was higher than that in mild psoriasis patients, and the risk of hypertension in psoriasis patients was higher than that in nonpsoriasis patients in Europe and Asia.
   Conclusion: We conducted this meta-analysis using the adjusted-for-covariates odds ratio, demonstrating that psoriasis was associated with an increased risk of hypertension compared to those without psoriasis.
C1 [Duan, Xi; Mu, Yunzhu; Liu, Ting; Chen, Yujuan; Xiong, Xincai] North Sichuan Med Coll, Affiliated Hosp, Dept Dermatovenereol, Nanchong, Sichuan, Peoples R China.
   [Liu, Junbo; Wu, Tao] North Sichuan Med Coll, Affiliated Hosp, Dept Urol, Wenhua Rd 57, Nanchong 637000, Sichuan, Peoples R China.
   [Yu, Ruichao] Harvard Med Sch, Brigham & Womens Hosp, Dept Pulm, Boston, MA 02115 USA.
C3 North Sichuan Medical University; North Sichuan Medical University;
   Harvard University; Harvard Medical School; Harvard University Medical
   Affiliates; Brigham & Women's Hospital
RP Wu, T (corresponding author), North Sichuan Med Coll, Affiliated Hosp, Dept Urol, Wenhua Rd 57, Nanchong 637000, Sichuan, Peoples R China.
EM alhawking@163.com
RI Wu, Tao/IQV-1755-2023
FU Natural Science Foundation of Sichuan Provincial Department of Education
   [16ZB0227]; Scientific Research Foundation of Health and Family Planning
   Commission of Sichuan Province [17PJ155]; City of Nanchong Strategic
   Cooperation with Local Universities Foundation of Technology
   [NSMC20170421, NSMC20170111, 18SXHZ0581, 18SXHZ0128]
FX This work was supported by the Natural Science Foundation of Sichuan
   Provincial Department of Education (16ZB0227), Scientific Research
   Foundation of Health and Family Planning Commission of Sichuan Province
   (17PJ155), and City of Nanchong Strategic Cooperation with Local
   Universities Foundation of Technology (NSMC20170421, NSMC20170111,
   18SXHZ0581, 18SXHZ0128).
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NR 39
TC 25
Z9 26
U1 1
U2 11
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD FEB
PY 2020
VL 99
IS 9
AR e19303
DI 10.1097/MD.0000000000019303
PG 9
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA LD2LY
UT WOS:000525865600050
PM 32118749
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU de Oliveira, IGB
   Ferreira, MD
   Lopes, PR
   Campos, DBT
   Ferreira-Neto, ML
   Santos, EHR
   Mathias, PCD
   Francisco, FA
   Koike, BD
   de Castro, CH
   Freiria-Oliveira, AH
   Pedrino, GR
   Gomes, RM
   Rosa, DA
AF Barbieri de Oliveira, Isis Gabrielli
   Ferreira Junior, Marcos Divino
   Lopes, Paulo Ricardo
   Taveira Campos, Dhiogenes Balsanufo
   Ferreira-Neto, Marcos Luiz
   Rosa Santos, Eduardo Henrique
   de Freitas Mathias, Paulo Cezar
   Francisco, Flavio Andrade
   Koike, Bruna Del Vechio
   de Castro, Carlos Henrique
   Freiria-Oliveira, Andre Henrique
   Pedrino, Gustavo Rodrigues
   Gomes, Rodrigo Mello
   Rosa, Daniel Alves
TI Forced internal desynchrony induces cardiometabolic alterations in adult
   rats
SO JOURNAL OF ENDOCRINOLOGY
LA English
DT Article
DE insulin resistance; circadian rhythms; metabolism; blood pressure;
   corticosteroids
ID CIRCADIAN TIMING SYSTEM; MOTOR-ACTIVITY RHYTHM; SUPRACHIASMATIC NUCLEUS;
   BLOOD-PRESSURE; BAROREFLEX SENSITIVITY; METABOLIC SYNDROME; OXIDATIVE
   STRESS; CLOCK PROTEIN; GENE; CORTICOSTERONE
AB Disruptions in circadian rhythms have been associated with several diseases, including cardiovascular and metabolic disorders. Forced internal desynchronization induced by a period of T-cycles of 22 h (T22 protocol) reaches the lower limit of entrainment and dissociates the circadian rhythmicity of the locomotor activity into two components, driven by different outputs from the suprachiasmatic nucleus (SCN). The main goal of this study was to evaluate the cardiovascular and metabolic response in rats submitted to internal desynchronization by T22 protocol. Male Wistar rats were assigned to either a control group subjected to a usual T-cycles of 24 h (12 h-12 h) or an experimental group subjected to the T22 protocol involving a 22-h symmetric light-dark cycle (11 h-11 h). After 8 weeks, rats subjected to the T22 exhibited desynchrony in their locomotor activity. Although plasma glucose and insulin levels were similar in both groups, desynchronized rats demonstrated dyslipidemia, significant hypertrophy of the fasciculate zone of the adrenal gland, low IRB, IRS2, PI3K, AKT, SOD and CAT protein expression and an increased expression of phosphoenolpyruvate carboxykinase in the liver. Furthermore, though they maintained normal baseline heart rates and mean arterial pressure levels, they also presented reduced baroreflex sensitivity. The findings indicate that circadian timing desynchrony following the T22 protocol can induce cardiometabolic disruptions. Early hepatic metabolism dysfunction can trigger other disorders, though additional studies are needed to clarify the causes.
C1 [Barbieri de Oliveira, Isis Gabrielli; Ferreira Junior, Marcos Divino; Lopes, Paulo Ricardo; Taveira Campos, Dhiogenes Balsanufo; Freiria-Oliveira, Andre Henrique; Pedrino, Gustavo Rodrigues; Gomes, Rodrigo Mello; Rosa, Daniel Alves] Univ Fed Goias, Biol Sci Inst, Ctr Neurosci & Cardiovasc Res, Goiania, Go, Brazil.
   [Ferreira-Neto, Marcos Luiz; Rosa Santos, Eduardo Henrique] Univ Fed Uberlandia, Inst Biomed Sci, Dept Physiol, Lab Electrophysiol & Cardiovasc Physiol, Uberlandia, MG, Brazil.
   [de Freitas Mathias, Paulo Cezar; Francisco, Flavio Andrade] Univ Estadual Maringa, Dept Biotechnol Genet & Cell Biol, Lab Secret Cell Biol, Maringa, Parana, Brazil.
   [Koike, Bruna Del Vechio] Fed Univ San Francisco Valley, Med Dept, Petrolina, PE, Brazil.
   [de Castro, Carlos Henrique] Univ Fed Goias, Biol Sci Inst, Dept Physiol Sci, Integrat Lab Cardiovasc & Neurol Pathophysiol, Goiania, Go, Brazil.
C3 Universidade Federal de Goias; Universidade Federal de Uberlandia;
   Universidade Estadual de Maringa; Universidade Federal de Goias
RP Rosa, DA (corresponding author), Univ Fed Goias, Biol Sci Inst, Ctr Neurosci & Cardiovasc Res, Goiania, Go, Brazil.
EM danielr@ufg.br
RI Lopes, Paulo/ABF-7073-2020; Ferreira, Marcos/AAF-3932-2021;
   Freiria-Oliveira, Andre/F-2756-2012; Rosa, Daniel/E-5429-2018; DE
   FREITAS MATHIAS, PAULO/AAQ-9682-2021; Santos, Eduardo/GQA-9786-2022; Del
   Vechio Koike, Bruna/AAE-7835-2019; Ferreira-Junior, Marcos
   Divino/IXD-8953-2023; Castro, Carlos/AFB-9482-2022; Mello Gomes,
   Rodrigo/L-2639-2016; R. Pedrino, Gustavo/I-5614-2015; Ferreira-Neto,
   Marcos Luiz/O-3368-2014; Castro, Carlos/H-2139-2013
OI Freiria-Oliveira, Andre Henrique/0000-0002-7511-5035; Mello Gomes,
   Rodrigo/0000-0002-9012-3287; de Freitas Mathias, Paulo
   Cezar/0000-0001-6994-4585; Ferreira-Junior, Marcos
   Divino/0000-0003-0490-1212; R. Pedrino, Gustavo/0000-0003-0488-5400;
   Henrique Rosa Santos, Eduardo/0000-0001-8078-3217; Koike,
   Bruna/0000-0001-9745-3513; Lopes, Paulo Ricardo/0000-0002-4141-2613;
   Ferreira-Neto, Marcos Luiz/0000-0002-9695-7100; Barbieri, Isis
   Gabrielli/0000-0002-6416-0754; Castro, Carlos/0000-0002-9510-1124
FU Fundacao de Amparo a Pesquisa do Estado de Goias
   [FAPEG-201210267001075/005-2012]; Conselho Nacional de Desenvolvimento
   Cientifico e Tecnologico [CNPq-449320/2014-6]
FX This work was supported by Fundacao de Amparo a Pesquisa do Estado de
   Goias (FAPEG-201210267001075/005-2012) and Conselho Nacional de
   Desenvolvimento Cientifico e Tecnologico (CNPq-449320/2014-6), neither
   of which was involved in the design, data collection or data analysis of
   the study, nor in the decision to publish or prepare the manuscript.
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NR 58
TC 6
Z9 6
U1 0
U2 5
PU BIOSCIENTIFICA LTD
PI BRISTOL
PA EURO HOUSE, 22 APEX COURT WOODLANDS, BRADLEY STOKE, BRISTOL BS32 4JT,
   ENGLAND
SN 0022-0795
EI 1479-6805
J9 J ENDOCRINOL
JI J. Endocrinol.
PD AUG
PY 2019
VL 242
IS 2
BP 25
EP 36
DI 10.1530/JOE-19-0026
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA IT4BX
UT WOS:000482805000007
PM 31071682
OA Bronze
DA 2025-06-11
ER

PT J
AU Kanczkowski, W
   Sue, M
   Bornstein, SR
AF Kanczkowski, Waldemar
   Sue, Mariko
   Bornstein, Stefan R.
TI The adrenal gland microenvironment in health, disease and during
   regeneration
SO HORMONES-INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM
LA English
DT Review
DE Adrenal insufficiency; ACTH; Cell transplantation;
   Hypothalamic-pituitary-adrenal axis; Immune-adrenal crosstalk; Obesity;
   Sepsis
ID BOVINE ADRENOCORTICAL-CELLS; MESENCHYMAL STEM-CELLS; TOLL-LIKE
   RECEPTORS; METABOLIC SYNDROME; ENDOTHELIAL-CELLS; SEPTIC SHOCK; SCID
   MICE; CHRONIC CORTICOSTERONE; INFLAMMATORY RESPONSE;
   PLASMA-CATECHOLAMINES
AB The adrenal gland is a key component of the stress system in the human body. Multiple direct and paracrine interactions between different cell types and their progenitors take place within the adrenal gland microenvironment. These unique interactions are supported by high vascularization and the adrenal cortex extracellular matrix. Alterations in the adrenal gland microenvironment are known to influence the progression of several pathological conditions, such as obesity and sepsis, and to be influenced by these disorders. For example, it has been suggested that activation of immune-adrenal crosstalk during sepsis induces elevated adrenal glucocorticoid levels, whereas crosstalk between adrenocortical cells and sonic hedgehog responsive stem cells was found to contribute to the increased size of the adrenal cortex during obesity. By contrast to sepsis, where activation of adrenal glucocorticoid production has protective effects, chronic exposure to high levels of glucocorticoids induces adverse effects, typically manifested in patients with Cushing syndrome, such as increased body weight, dyslipidemia, glucose intolerance, and hypertension. Therefore, a better understanding of factors involved in the regulation of the adrenal gland microenvironment is crucial. This review highlights bidirectional interactions occurring between the adrenal gland microenvironment and systemic responses during obesity and sepsis. Furthermore, it presents and discusses recent advancements and challenges in attempts to restore or regenerate adrenal gland function, including the use of oxygenated immune-isolating devices.
C1 [Kanczkowski, Waldemar; Sue, Mariko; Bornstein, Stefan R.] Tech Univ Dresden, Dept Internal Med 3, Fetscherstr 74, D-01307 Dresden, Germany.
   [Bornstein, Stefan R.] Kings Coll London, Dept Endocrinol & Diabetes, London, England.
C3 Technische Universitat Dresden; University of London; King's College
   London
RP Kanczkowski, W (corresponding author), Tech Univ Dresden, Dept Internal Med 3, Fetscherstr 74, D-01307 Dresden, Germany.
EM waldemar.kanczkowski@uniklinikum-dresden.de
OI Kanczkowski, Waldemar/0000-0002-5595-8393
FU Deutsche Forschungs Gemeinschaft (DFG) [KA 3013/2-2, BO 1141/11-2]
FX This work was supported by grants of the Deutsche Forschungs
   Gemeinschaft (DFG) to WK (KA 3013/2-2) and SRB (BO 1141/11-2).
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NR 151
TC 20
Z9 21
U1 0
U2 12
PU SPRINGER INT PUBL AG
PI CHAM
PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND
SN 1109-3099
EI 2520-8721
J9 HORM-INT J ENDOCRINO
JI Horm.-Int. J. Endocrinol. Metab.
PD JUL-SEP
PY 2017
VL 16
IS 3
BP 251
EP 265
DI 10.1007/BF03401519
PG 15
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA FQ7SI
UT WOS:000418562600003
PM 29278511
DA 2025-06-11
ER

PT J
AU Rodríguez-Rodríguez, E
   López-Sobaler, AM
   Navia, B
   Andrés, P
   Jiménez-Ortega, AI
   Ortega, RM
AF Rodriguez-Rodriguez, Elena
   Lopez-Sobaler, Ana M.
   Navia, Beatriz
   Andres, Pedro
   Jimenez-Ortega, Ana I.
   Ortega, Rosa M.
TI β-Carotene Concentration and Its Association with Inflammatory
   Biomarkers in Spanish Schoolchildren
SO ANNALS OF NUTRITION AND METABOLISM
LA English
DT Article
DE beta-Carotene; Inflammation; Children
ID RECENT NATIONAL SURVEYS; BODY-MASS INDEX; NF-KAPPA-B; ALPHA-TOCOPHEROL;
   SERUM CAROTENOIDS; OXIDATIVE STRESS; SUBCLINICAL INFLAMMATION; METABOLIC
   SYNDROME; ATOPIC-DERMATITIS; VEGETABLE INTAKE
AB Aim: To examine the correlation between inflammatory bio-markers and plasma beta-carotene levels in children. Methods: A total of 564 Spanish schoolchildren aged 9-12 were observed and studied. Plasma beta-carotene levels were assessed by HPLC. A beta-carotene level <4.83 mu g/dL (0.09 mu mol/L) was considered deficient. Plasma tumour necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) were measured by immunoenzyme assays. Serum high-sensitivity C-reactive protein (hs-CRP) was tested by immunonephelometry. Results: Subjects who were beta-carotene-deficient (23.1% of the studied children) had higher IL-6 levels than subjects with normal beta-carotene concentrations. The log-IL-6 and log-hs-CRP concentrations, but not the log-TNF-alpha level, were strongly and inversely related to the plasma log-beta-carotene level (taking into account log-age, energy intake, log-triglycerides, gender, log-body mass index, log-beta-carotene intake, energy from lipids and cholesterol as covariables). When the 3 inflammatory biomarkers were introduced into the regression model along with the corresponding covariables, only the log-IL-6 level was related to the plasma log-beta-carotene level beta = -0.505 +/- 0.078; p < 0.001). Conclusions: Inflammatory status, in particular IL-6 levels, appears to be negatively associated with plasma beta-carotene levels in schoolchildren. (C) 2017 S. Karger AG, Basel
C1 [Rodriguez-Rodriguez, Elena; Andres, Pedro] Univ Complutense Madrid, Secc Dept Quim Analit, Fac Farm, ES-28040 Madrid, Spain.
   [Lopez-Sobaler, Ana M.; Navia, Beatriz; Ortega, Rosa M.] Univ Complutense Madrid, Dept Nutr, Fac Farm, Madrid, Spain.
   [Jimenez-Ortega, Ana I.] Hosp San Rafael, Gastroenterol Pediat, Madrid, Spain.
   [Rodriguez-Rodriguez, Elena; Lopez-Sobaler, Ana M.; Navia, Beatriz; Andres, Pedro; Ortega, Rosa M.] UCM Res Grp VALORNUT, Madrid, Spain.
C3 Complutense University of Madrid; Complutense University of Madrid
RP Rodríguez-Rodríguez, E (corresponding author), Univ Complutense Madrid, Secc Dept Quim Analit, Fac Farm, ES-28040 Madrid, Spain.
EM elerodri@farm.ucm.es
RI Jiménez, Ana/I-2750-2017; Ortega, Rosa/S-5760-2016; Rodriguez-Rodriguez,
   Elena/I-1836-2017; Lopez-Sobaler, Ana M/I-3589-2016
OI Rodriguez-Rodriguez, Elena/0000-0003-3513-4642; Lopez-Sobaler, Ana
   M/0000-0002-4133-1450
FU FISS [PI060318]; Creation and Consolidation Program Research Group at
   the Complutense University of Madrid, Madrid [GR58/O8, 4120787]
FX This work was funded by the FISS project PI060318 and the "Creation and
   Consolidation Program Research Group at the Complutense University of
   Madrid, Madrid" (ref: GR58/O8; code: 4120787).
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PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0250-6807
EI 1421-9697
J9 ANN NUTR METAB
JI Ann. Nutr. Metab.
PY 2017
VL 71
IS 1-2
BP 80
EP 87
DI 10.1159/000479009
PG 8
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA FH2GQ
UT WOS:000410957500007
PM 28704820
DA 2025-06-11
ER

PT J
AU Benzler, J
   Ganjam, GK
   Pretz, D
   Oelkrug, R
   Koch, CE
   Legler, K
   Stöhr, S
   Culmsee, C
   Williams, LM
   Tups, A
AF Benzler, Jonas
   Ganjam, Goutham K.
   Pretz, Dominik
   Oelkrug, Rebecca
   Koch, Christiane E.
   Legler, Karen
   Stoehr, Sigrid
   Culmsee, Carsten
   Williams, Lynda M.
   Tups, Alexander
TI Central Inhibition of IKKβ/NF-κB Signaling Attenuates High-Fat
   Diet-Induced Obesity and Glucose Intolerance
SO DIABETES
LA English
DT Article
ID CENTRAL LEPTIN RESISTANCE; INSULIN-RESISTANCE; GENE-EXPRESSION; ARCUATE
   NUCLEUS; REGULATED GENE; BODY-WEIGHT; INFLAMMATION; MICE; BRAIN; STRESS
AB Metabolic inflammation in the central nervous system might be causative for the development of overnutrition-induced metabolic syndrome and related disorders, such as obesity, leptin and insulin resistance, and type 2 diabetes. Here we investigated whether nutritive and genetic inhibition of the central I kappa B kinase beta (IKK beta)/nuclear factor-kappa B (NF-kappa B) pathway in diet-induced obese (DIO) and leptin-deficient mice improves these metabolic impairments. A known prominent inhibitor of IKK beta/NF-kappa B signaling is the dietary flavonoid butein. We initially determined that oral, intraperitoneal, and intracerebroventricular administration of this flavonoid improved glucose tolerance and hypothalamic insulin signaling. The dose-dependent glucose-lowering capacity was profound regardless of whether obesity was caused by leptin deficiency or high-fat diet (HFD). To confirm the apparent central role of IKK beta/NF-kappa B signaling in the control of glucose and energy homeostasis, we genetically inhibited this pathway in neurons of the arcuate nucleus, one key center for control of energy homeostasis, via specific adeno-associated virus serotype 2-mediated overexpression of I kappa B alpha, which inhibits NF-kappa B nuclear translocation. This treatment attenuated HFD-induced body weight gain, body fat mass accumulation, increased energy expenditure, and reduced arcuate suppressor of cytokine signaling 3 expression, indicative for enhanced leptin signaling. These results reinforce a specific role of central proinflammatory IKK beta/NF-kappa B signaling in the development and potential treatment of DIO-induced comorbidities.
C1 [Benzler, Jonas; Pretz, Dominik; Oelkrug, Rebecca; Koch, Christiane E.; Legler, Karen; Stoehr, Sigrid; Tups, Alexander] Univ Marburg, Fac Biol, Dept Anim Physiol, Marburg, Germany.
   [Ganjam, Goutham K.; Culmsee, Carsten] Univ Marburg, Fac Pharm, Inst Pharmacol & Clin Pharm, Marburg, Germany.
   [Williams, Lynda M.] Univ Aberdeen, Rowett Inst Nutr & Hlth, Metabol Hlth Grp, Aberdeen, Scotland.
   [Tups, Alexander] Univ Otago, Dept Physiol, Ctr Neuroendocrinol, Dunedin, New Zealand.
C3 Philipps University Marburg; Philipps University Marburg; University of
   Aberdeen; University of Otago
RP Tups, A (corresponding author), Univ Marburg, Fac Biol, Dept Anim Physiol, Marburg, Germany.
EM alexander.tups@otago.ac.nz
RI Culmsee, Carsten/ABC-3120-2021
OI Culmsee, Carsten/0000-0002-5121-5015
FU German Ministry of Education and Research [0315087]; German Research
   Foundation [0315087, 243471766]; Scottish Government's Rural and
   Environment Science and Analytical Services Division
FX This study was funded by the German Ministry of Education and Research
   (ref. no. 0315087) and the German Research Foundation (ref. no. 0315087
   and 243471766 to AT.). L.M.W. was funded by the Scottish Government's
   Rural and Environment Science and Analytical Services Division.
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NR 45
TC 109
Z9 121
U1 1
U2 26
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0012-1797
EI 1939-327X
J9 DIABETES
JI Diabetes
PD JUN
PY 2015
VL 64
IS 6
BP 2015
EP 2027
DI 10.2337/db14-0093
PG 13
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA CJ3GH
UT WOS:000355370900018
PM 25626735
DA 2025-06-11
ER

PT J
AU Chacko, BK
   Kramer, PA
   Ravi, S
   Benavides, GA
   Mitchell, T
   Dranka, BP
   Ferrick, D
   Singal, AK
   Ballinger, SW
   Bailey, SM
   Hardy, RW
   Zhang, JH
   Zhi, DG
   Darley-Usmar, VM
AF Chacko, Balu K.
   Kramer, Philip A.
   Ravi, Saranya
   Benavides, Gloria A.
   Mitchell, Tanecia
   Dranka, Brian P.
   Ferrick, David
   Singal, Ashwani K.
   Ballinger, Scott W.
   Bailey, Shannon M.
   Hardy, Robert W.
   Zhang, Jianhua
   Zhi, Degui
   Darley-Usmar, Victor M.
TI The Bioenergetic Health Index: a new concept in mitochondrial
   translational research
SO CLINICAL SCIENCE
LA English
DT Article
DE aging; cardiovascular disease; haplotype; hepatotoxicity;
   neurodegenerative disease; oxidative stress; reserve capacity
ID BLOOD MONONUCLEAR-CELLS; METABOLIC SYNDROME; DYSFUNCTION; DISEASE;
   DIFFERENTIATION; LYMPHOCYTES; HOMEOSTASIS; APOPTOSIS; PROFILES; CAPACITY
AB Bioenergetics has become central to our understanding of pathological mechanisms, the development of new therapeutic strategies and as a biomarker for disease progression in neurodegeneration, diabetes, cancer and cardiovascular disease. A key concept is that the mitochondrion can act as the 'canary in the coal mine' by serving as an early warning of bioenergetic crisis in patient populations. We propose that new clinical tests to monitor changes in bioenergetics in patient populations are needed to take advantage of the early and sensitive ability of bioenergetics to determine severity and progression in complex and multifactorial diseases. With the recent development of high-throughput assays to measure cellular energetic function in the small number of cells that can be isolated from human blood these clinical tests are now feasible. We have shown that the sequential addition of well-characterized inhibitors of oxidative phosphorylation allows a bioenergetic profile to be measured in cells isolated from normal or pathological samples. From these data we propose that a single value the Bioenergetic Health Index (BHI) can be calculated to represent the patient's composite mitochondrial profile for a selected cell type. In the present Hypothesis paper, we discuss how BHI could serve as a dynamic index of bioenergetic health and how it can be measured in platelets and leucocytes. We propose that, ultimately, BHI has the potential to be a new biomarker for assessing patient health with both prognostic and diagnostic value.
C1 [Chacko, Balu K.; Kramer, Philip A.; Ravi, Saranya; Benavides, Gloria A.; Mitchell, Tanecia; Ballinger, Scott W.; Hardy, Robert W.; Zhang, Jianhua; Darley-Usmar, Victor M.] Univ Alabama Birmingham, Mitochondrial Med Lab, Birmingham, AL 35294 USA.
   [Chacko, Balu K.; Kramer, Philip A.; Ravi, Saranya; Benavides, Gloria A.; Mitchell, Tanecia; Ballinger, Scott W.; Bailey, Shannon M.; Hardy, Robert W.; Zhang, Jianhua; Darley-Usmar, Victor M.] Univ Alabama Birmingham, Dept Pathol, Birmingham, AL 35294 USA.
   [Dranka, Brian P.; Ferrick, David] Seahorse Biosci, North Billerica, MA 01862 USA.
   [Singal, Ashwani K.] Univ Alabama Birmingham, Dept Internal Med, Div Gastroenterol & Hepatol, Birmingham, AL 35294 USA.
   [Zhang, Jianhua] Med Ctr, Dept Veteran Affairs, Birmingham, AL 35294 USA.
   [Zhi, Degui] Univ Alabama Birmingham, Dept Biostat, Birmingham, AL 35294 USA.
C3 University of Alabama System; University of Alabama Birmingham;
   University of Alabama System; University of Alabama Birmingham;
   University of Alabama System; University of Alabama Birmingham;
   University of Alabama System; University of Alabama Birmingham
RP Darley-Usmar, VM (corresponding author), Univ Alabama Birmingham, Mitochondrial Med Lab, Birmingham, AL 35294 USA.
EM darley@uab.edu
RI zhang, jianhua/D-3404-2009; Kramer, Philip/GYJ-8215-2022; zhi,
   Degui/B-1748-2008; Singal, Ashwani/H-6181-2019; Darley-Usmar,
   Victor/F-7656-2010; Dranka, Brian/B-8701-2016
OI Zhang, Jianhua/0000-0002-2128-9574; Darley-Usmar,
   Victor/0000-0001-8921-7086; Bailey, Shannon/0000-0003-0002-3424; Dranka,
   Brian/0000-0002-1377-377X; Kramer, Philip/0000-0001-6554-631X
FU American Heart Association; National Institutes of Health [T32HL07918,
   T32HL007457]; O'Brien Center [P30 DK079337, R01 AA018841, R01 HL092857,
   R01 NS064090]; National Institutes of Diabetes and Digestive and Kidney
   Diseases (NIDDK) Diabetic Complications Consortium [DK076169]; Veterans
   Affairs merit award
FX Our own work is supported by the American Heart Association (to S.R.),
   the National Institutes of Health [grant numbers T32HL07918 (to PA.K.),
   T32HL007457 (to T.M.), O'Brien Center P30 DK079337 (to V.D.U.), R01
   AA018841 (to S.M.B.), R01 HL092857 (to S.M.B.) and R01 NS064090],
   National Institutes of Diabetes and Digestive and Kidney Diseases
   (NIDDK) Diabetic Complications Consortium (DiaComp;
   http://www.diacomp.org) [grant number DK076169 (sub-award to V.D.U.)],
   and a Veterans Affairs merit award (to
CR [Anonymous], BIOCH BIOPHYSICA ACT
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NR 39
TC 268
Z9 305
U1 1
U2 29
PU PORTLAND PRESS LTD
PI LONDON
PA CHARLES DARWIN HOUSE, 12 ROGER STREET, LONDON WC1N 2JU, ENGLAND
SN 0143-5221
EI 1470-8736
J9 CLIN SCI
JI Clin. Sci.
PD SEP
PY 2014
VL 127
IS 5-6
BP 367
EP 373
DI 10.1042/CS20140101
PG 7
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA AM4XQ
UT WOS:000339859900009
PM 24895057
OA Green Submitted, Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Durrant, LM
   Khorram, O
   Buchholz, JN
   Pearce, WJ
AF Durrant, Lara M.
   Khorram, Omid
   Buchholz, John N.
   Pearce, William J.
TI Maternal food restriction modulates cerebrovascular structure and
   contractility in adult rat offspring: effects of metyrapone
SO AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE
   PHYSIOLOGY
LA English
DT Article
DE cerebral arteries; glucocorticoids; myogenic reactivity; myosin
   heavychain-isoforms; smooth muscle phenotype
ID SMOOTH-MUSCLE; NUTRIENT RESTRICTION; PROTEIN RESTRICTION;
   BLOOD-PRESSURE; GLUCOCORTICOID EXPOSURE; DEVELOPMENTAL ORIGINS; DIETARY
   RESTRICTION; ANGIOTENSIN SYSTEM; METABOLIC SYNDROME; VASCULAR FUNCTION
AB Although the effects of prenatal undernutrition on adult cardiovascular health have been well studied, its effects on the cerebrovascular structure and function remain unknown. We used a pair-fed rat model of 50% caloric restriction from day 11 of gestation to term, with ad libitum feeding after birth. We validated that maternal food restriction (MFR) stress is mediated by glucocorticoids by administering metyrapone, a corticosterone synthesis inhibitor, to MFR mothers at day 11 of gestation. At age 8 mo, offspring from Control, MFR, and MFR + Metyrapone groups were killed, and middle cerebral artery (MCA) segments were studied using vessel-bath myography and confocal microscopy. Colocalization of smooth muscle alpha-actin (SM alpha A) with nonmuscle (NM), SM1 and SM2 myosin heavy-chain (MHC) isoforms was used to assess smooth muscle phenotype. Our results indicate that artery stiffness and wall thickness were increased, pressure-evoked myogenic reactivity was depressed, and myofilament Ca2+ sensitivity was decreased in offspring of MFR compared with Control rats. MCA from MFR offspring exhibited a significantly greater SM alpha A/NM colocalization, suggesting that the smooth muscle cells had been altered toward a noncontractile phenotype. MET significantly reversed the effects of MFR on stiffness but not myogenic reactivity, lowered SM alpha A/ NM colocalization, and increased SM alpha A/SM2 colocalization. Together, our data suggest that MFR alters cerebrovascular contractility via both glucocorticoid-dependent and glucocorticoidindependent mechanisms.
C1 [Durrant, Lara M.; Buchholz, John N.; Pearce, William J.] Loma Linda Univ, Sch Med, Ctr Perinatal Biol, Div Physiol, Loma Linda, CA 92350 USA.
   [Durrant, Lara M.; Buchholz, John N.; Pearce, William J.] Loma Linda Univ, Sch Med, Ctr Perinatal Biol, Div Pharmacol, Loma Linda, CA 92350 USA.
   [Khorram, Omid] Harbor Univ Calif, Los Angeles Med Ctr, Dept Obstet & Gynecol, Torrance, CA USA.
C3 Loma Linda University; Loma Linda University; University of California
   System; University of California Los Angeles; University of California
   Los Angeles Medical Center
RP Pearce, WJ (corresponding author), Loma Linda Univ, Sch Med, Ctr Perinatal Biol, Loma Linda, CA 92350 USA.
EM wpearce@llu.edu
RI Buchholz, John/AAY-3443-2020
OI Pearce, William/0000-0002-5331-5677
FU National Institutes of Health [HD-054920, HD-31266, HL-54120, HL-64867];
   Loma Linda University School of Medicine; Div Of Biological
   Infrastructure; Direct For Biological Sciences [0923559] Funding Source:
   National Science Foundation
FX The work reported in this manuscript was supported by National
   Institutes of Health Grants HD-054920, HD-31266, HL-54120, HL-64867, and
   the Loma Linda University School of Medicine.
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NR 72
TC 19
Z9 20
U1 0
U2 9
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0363-6119
EI 1522-1490
J9 AM J PHYSIOL-REG I
JI Am. J. Physiol.-Regul. Integr. Comp. Physiol.
PD MAR
PY 2014
VL 306
IS 6
BP R401
EP R410
DI 10.1152/ajpregu.00436.2013
PG 10
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA AD3YO
UT WOS:000333182600004
PM 24477541
OA Green Published
DA 2025-06-11
ER

PT J
AU Chitapanarux, T
   Tienboon, P
   Pojchamarnwiputh, S
   Leelarungrayub, D
AF Chitapanarux, Taned
   Tienboon, Prasong
   Pojchamarnwiputh, Suwalee
   Leelarungrayub, Donrawee
TI Open-labeled pilot study of cysteine-rich whey protein isolate
   supplementation for nonalcoholic steatohepatitis patients
SO JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
LA English
DT Article
DE glutathione; nonalcoholic steatohepatitis; whey protein isolate
ID INSULIN-RESISTANCE; METABOLIC SYNDROME; DISEASE
AB Glutathione (GSH) depletion contributes to liver injury and development of steatohepatitis. Undenatured cysteine-rich whey protein isolate has been clinically proven to raise GSH in several patient groups. The aim of this study was to evaluate the effect of oral supplementation with whey protein on patients with nonalcoholic steatohepatitis (NASH).
   In an open-labeled clinical trial, 38 patients (18 male, 20 female; mean age 48 +/- 14 years) with NASH confirmed by computed tomography measurements and liver biochemistries were given with a daily dose of 20 g whey protein isolate for 12 weeks.
   A significant reduction in alanine aminotransferase (ALT) (64 +/- 72 vs 46 +/- 36, P = 0.016) and aspartate aminotransferase (AST) (45 +/- 49 vs 33 +/- 18, P = 0.047) were observed. Plasma glutathione and total antioxidant capacity increased significantly at the end of study (53 +/- 11 vs 68 +/- 11, P < 0.05 and 1.26 +/- 0.10 vs 2.03 +/- 0.10, P < 0.05). Liver attenuation index improved from -13.4 +/- 11.1 to -9.7 +/- 13.1 (P = 0.048). Hepatic macrovesicular steatosis decreased significantly after 12 weeks of supplementation (33.82 +/- 12.82 vs 30.66 +/- 15.96, P = 0.046). Whey protein isolate was well tolerated. No serious adverse events were observed.
   The results indicate that oral supplementation of cysteine-rich whey protein isolate leads to improvements in liver biochemistries, increased plasma GSH, total antioxidant capacity and reduced hepatic macrovesicular steatosis in NASH patients. The results support the role of oxidative stress in the pathogenesis of this disease.
C1 [Chitapanarux, Taned] Chiang Mai Univ, Fac Med, Dept Med, Div Gastrohepatol, Chiang Mai 50200, Thailand.
   [Tienboon, Prasong] Chiang Mai Univ, Fac Med, Dept Pediat, Div Nutr, Chiang Mai 50200, Thailand.
   [Pojchamarnwiputh, Suwalee] Chiang Mai Univ, Fac Med, Div Diagnost Radiol, Dept Radiol, Chiang Mai 50200, Thailand.
   [Leelarungrayub, Donrawee] Chiang Mai Univ, Fac Associated Med Sci, Dept Phys Therapy, Chiang Mai 50200, Thailand.
C3 Chiang Mai University; Chiang Mai University; Chiang Mai University;
   Chiang Mai University
RP Chitapanarux, T (corresponding author), Chiang Mai Univ, Fac Med, Dept Med, Div Gastrohepatol, Chiang Mai 50200, Thailand.
EM thaitaned@yahoo.com
RI Chitapanarux, Taned/AAV-5856-2020; Leelarungrayub,
   donrawee/JRY-4478-2023
OI Chitapanarux, Taned/0000-0002-9908-3680
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NR 20
TC 47
Z9 54
U1 0
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0815-9319
EI 1440-1746
J9 J GASTROEN HEPATOL
JI J. Gastroenterol. Hepatol.
PD JUN
PY 2009
VL 24
IS 6
BP 1045
EP 1050
DI 10.1111/j.1440-1746.2009.05865.x
PG 6
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 451IX
UT WOS:000266465000020
PM 19638084
DA 2025-06-11
ER

PT J
AU Wang, HJ
   Cai, WJ
   Zeng, H
   Xu, ZK
   Luo, X
   Wu, JH
   Lin, YD
   Wang, ZS
AF Wang, Hongjin
   Cai, Wenjing
   Zeng, Hao
   Xu, Zengkai
   Luo, Xin
   Wu, Jiahuang
   Lin, Youdong
   Wang, Zhisheng
TI Inflammatory markers mediate the association between weight-adjusted
   waist circumference and mortality in patients with cardiometabolic
   syndrome
SO SCIENTIFIC REPORTS
LA English
DT Article
DE Cardiometabolic Syndrome; Weight-Adjusted Waist Circumference Index;
   Mortality; Inflammatory Markers; Mediation Analysis; NHANES
ID METABOLIC SYNDROME; OXIDATIVE STRESS; RISK-FACTORS; ALL-CAUSE;
   MECHANISMS
AB Cardiometabolic Syndrome (CMS) is associated with increased risks of cardiovascular disease, type 2 diabetes mellitus, and all-cause mortality. The Weight-Adjusted Waist Circumference Index (WWI) has emerged as a novel metric for assessing obesity and its health implications. To investigate the relationship between WWI and mortality in CMS patients, considering the mediating role of inflammatory markers. The study analyzed the National Health and Nutrition Examination Survey (NHANES) data from 2003 to 2018 and identified 6506 patients with CMS. WWI was calculated as the square root of waist circumference (cm) divided by weight (kg). Mortality data were correlated with the National Death Index (NDI). Cox regression models, adjusted for demographic and clinical covariates, assessed the effect of WWI on all-cause and cause-specific mortality. Finally, the role of inflammatory markers in the relationship between WWI and mortality was explored using mediation analysis. The study observed a positive linear association between WWI and all-cause, cardiovascular, and diabetes-related mortalities among CMS patients. After adjusting for demographic and clinical confounders, WWI remained a significant predictor of mortality. Mediation analysis revealed that inflammatory markers, particularly the neutrophil and systemic immune-inflammation index (SII), significantly mediated the relationship between WWI and all-cause mortality. WWI is an independent predictor of mortality in CMS patients, with inflammation potentially linking obesity to mortality risk. These findings may inform clinical risk assessment and management strategies for CMS.
C1 [Wang, Hongjin; Xu, Zengkai; Luo, Xin; Wu, Jiahuang; Wang, Zhisheng] Fujian Med Univ, Longyan Affiliated Hosp 1, Dept Cardiothorac Surg, 105 Jiuyi North Rd, Longyan 364000, Fujian, Peoples R China.
   [Cai, Wenjing] Fujian Med Univ, Fuzhou, Peoples R China.
   [Zeng, Hao] Fujian Med Univ, Longyan Affiliated Hosp 1, Dept Gastroenterol & Anorectal Surg, Longyan, Peoples R China.
   [Lin, Youdong] Fuzhou Univ, Affiliated Prov Hosp, Dept Clin Lab, 134 East St, Fuzhou 350001, Fujian, Peoples R China.
C3 Fujian Medical University; Fujian Medical University; Fujian Medical
   University; Fuzhou University
RP Wang, ZS (corresponding author), Fujian Med Univ, Longyan Affiliated Hosp 1, Dept Cardiothorac Surg, 105 Jiuyi North Rd, Longyan 364000, Fujian, Peoples R China.; Lin, YD (corresponding author), Fuzhou Univ, Affiliated Prov Hosp, Dept Clin Lab, 134 East St, Fuzhou 350001, Fujian, Peoples R China.
EM 2444734512@qq.com; doctorwzs@163.com
RI Lin, Youdong/AAT-5182-2021
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NR 49
TC 0
Z9 0
U1 3
U2 3
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD MAR 12
PY 2025
VL 15
IS 1
AR 8505
DI 10.1038/s41598-025-92733-y
PG 14
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 0CG5K
UT WOS:001443941100004
PM 40075096
OA gold
DA 2025-06-11
ER

PT J
AU Cilenti, L
   Di Gregorio, J
   Mahar, R
   Liu, F
   Ambivero, CT
   Periasamy, M
   Merritt, ME
   Zervos, AS
AF Cilenti, Lucia
   Di Gregorio, Jacopo
   Mahar, Rohit
   Liu, Fei
   Ambivero, Camilla T.
   Periasamy, Muthu
   Merritt, Matthew E.
   Zervos, Antonis S.
TI Inactivation of mitochondrial MUL1 E3 ubiquitin ligase deregulates
   mitophagy and prevents diet-induced obesity in mice
SO FRONTIERS IN MOLECULAR BIOSCIENCES
LA English
DT Article
DE MUL1; SCD1; lipogenesis; obesity; mitophagy
ID STEAROYL-COA DESATURASE-1; FATTY-ACID OXIDATION; ADIPOSE-TISSUE;
   PROTECTS; PROTEASE; MARKERS; STRESS; MAPL
AB Obesity is a growing epidemic affecting millions of people worldwide and a major risk factor for a multitude of chronic diseases and premature mortality. Accumulating evidence suggests that mitochondria have a profound role in diet-induced obesity and the associated metabolic changes, but the molecular mechanisms linking mitochondria to obesity remain poorly understood. Our studies have identified a new function for mitochondrial MUL1 E3 ubiquitin ligase, a protein known to regulate mitochondrial dynamics and mitophagy, in the control of energy metabolism and lipogenesis. Genetic deletion of Mul1 in mice impedes mitophagy and presents a metabolic phenotype that is resistant to high-fat diet (HFD)-induced obesity and metabolic syndrome. Several metabolic and lipidomic pathways are perturbed in the liver and white adipose tissue (WAT) of Mul1(-/-) animals on HFD, including the one driven by Stearoyl-CoA Desaturase 1 (SCD1), a pivotal regulator of lipid metabolism and obesity. In addition, key enzymes crucial for lipogenesis and fatty acid oxidation such as ACC1, FASN, AMPK, and CPT1 are also modulated in the absence of MUL1. The concerted action of these enzymes, in the absence of MUL1, results in diminished fat storage and heightened fatty acid oxidation. Our findings underscore the significance of MUL1-mediated mitophagy in regulating lipogenesis and adiposity, particularly in the context of HFD. Consequently, our data advocate the potential of MUL1 as a therapeutic target for drug development in the treatment of obesity, insulin resistance, NAFLD, and cardiometabolic diseases.
C1 [Cilenti, Lucia; Di Gregorio, Jacopo; Liu, Fei; Ambivero, Camilla T.; Periasamy, Muthu; Zervos, Antonis S.] Univ Cent Florida, Coll Med, Burnett Sch Biomed Sci, Orlando, FL 32827 USA.
   [Mahar, Rohit] Hemvati Nandan Bahuguna Garhwal Univ, Cent Univ, Dept Chem, Srinagar, Uttarakhand, India.
   [Merritt, Matthew E.] Univ Florida, Dept Biochem & Mol Biol, Gainesville, FL USA.
C3 State University System of Florida; University of Central Florida;
   Hemwati Nandan Bahuguna Garhwal University; State University System of
   Florida; University of Florida
RP Zervos, AS (corresponding author), Univ Cent Florida, Coll Med, Burnett Sch Biomed Sci, Orlando, FL 32827 USA.
EM antonis.zervos@ucf.edu
RI Di Gregorio, Jacopo/HKW-0312-2023
OI Di Gregorio, Jacopo/0000-0001-8865-2967
FU Burnett School of Biomedical Science; UCF College of Medicine; NIH
   [R01-DK132254]; Fondazione Umberto Veronesi (Italy)
FX The author(s) declare financial support was received for the research,
   authorship, and/or publication of this article. Funding for this work
   was provided by the Burnett School of Biomedical Science and the UCF
   College of Medicine to ASZ. MEM acknowledges the support of NIH
   R01-DK132254. JDG was supported by Fondazione Umberto Veronesi (Italy).
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NR 68
TC 1
Z9 1
U1 1
U2 3
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 2296-889X
J9 FRONT MOL BIOSCI
JI Front. Mol. Biosci.
PD APR 25
PY 2024
VL 11
AR 1397565
DI 10.3389/fmolb.2024.1397565
PG 15
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA PS6M1
UT WOS:001216111800001
PM 38725872
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Kaelin, BR
   McKenzie, CM
   Hempel, KW
   Lang, AL
   Arteel, GE
   Beier, JI
AF Kaelin, Brenna R.
   McKenzie, Collin M.
   Hempel, Karl W.
   Lang, Anna L.
   Arteel, Gavin E.
   Beier, Juliane, I
TI Adipose tissue-liver crosstalk during pathologic changes caused by vinyl
   chloride metabolites in mice
SO TOXICOLOGY AND APPLIED PHARMACOLOGY
LA English
DT Article
DE PVC; TASH; Plastic; Hepatotoxicity; Saturated fat; Metabolic syndrome
ID INSULIN-RESISTANCE; INJURY; DISEASE; OBESITY; DIET; STEATOHEPATITIS;
   INFLAMMATION; EXPOSURE; DEATH; FGF21
AB Volatile organic compounds (VOCs), such as vinyl chloride (VC), can be directly toxic at high concentrations. However, we have shown that 'nontoxic' exposures to VC and its metabolite chloroethanol (CE) enhances experimental non-alcoholic fatty liver disease (NAFLD), suggesting an unpredicted interaction. Importantly, VOC exposure has been identified as a potential risk factor for the development of obesity and its sequelae in humans. As there is a known axis between adipose and hepatic tissue in NAFLD, the impact of CE on white adipose tissue (WAT) inflammation and lipolysis was investigated. Mice were administered CE (or vehicle) once, after 10 weeks of being fed high-fat or low-fat diet (LFD). CE significantly enhanced hepatic steatosis and inflammation caused by HFD. HFD significantly increased the size of epididymal fat pads, which was enhanced by CE. The relative size of adipocyte lipid droplets increased by HFD+ CE, which was also correlated with increased expression of lipid-associated proteins (e.g., PLINs). CE also enhanced HFD-induced indices of WAT inflammation, and ER stress. Hepatic-derived circulating FGF21, a major modulator of WAT lipolysis, which is hypothesized to thereby regulate hepatic steatosis, was significantly increased by CE in animals fed HFD. Taken together these data support the hypothesis that environmental toxicant exposure can exacerbate the severity of NAFLD/NASH, involving the liver-adipose axis in this process. Specifically, CE enhances local inflammation and alters lipid metabolism and WAT-mediated hepatic steatosis due to changes in WAT lipolysis.
C1 [Kaelin, Brenna R.; McKenzie, Collin M.; Hempel, Karl W.; Lang, Anna L.] Univ Louisville, Dept Pharmacol & Toxicol, Louisville, KY 40292 USA.
   [Kaelin, Brenna R.; McKenzie, Collin M.; Hempel, Karl W.; Lang, Anna L.] Univ Louisville, Hepatobiol & Toxicol Program, Louisville, KY 40292 USA.
   [Arteel, Gavin E.; Beier, Juliane, I] Univ Pittsburgh, Dept Med, Div Gastroenterol Hepatol & Nutr, 200 Lothrop St, Pittsburgh, PA 15213 USA.
   [Arteel, Gavin E.; Beier, Juliane, I] Univ Pittsburgh, Pittsburgh Liver Res Ctr, Pittsburgh, PA 15213 USA.
C3 University of Louisville; University of Louisville; Pennsylvania
   Commonwealth System of Higher Education (PCSHE); University of
   Pittsburgh; Pennsylvania Commonwealth System of Higher Education
   (PCSHE); University of Pittsburgh
RP Beier, JI (corresponding author), Univ Pittsburgh, Dept Med, Div Gastroenterol Hepatol & Nutr, 200 Lothrop St, Pittsburgh, PA 15213 USA.
EM brka222@uky.edu; cmmckenz@wakehealth.edu; kwhemp01@louisville.edu;
   all159@med.miami.edu; gearteel@pitt.edu; jibeier@pitt.edu
RI Arteel, Gavin/AAE-2440-2022
OI Arteel, Gavin/0000-0002-2253-5984; Beier, Juliane/0000-0002-5395-5682
FU National Institutes of Health [K01 DK096042, R03 DK107912, P30DK120531];
   Institutional Development Award (IDeA) from the National Institute of
   General Medical Sciences of the National Institutes of Health
   [P20GM113226]; National Institute on Alcohol Abuse and Alcoholism of the
   National Institutes of Health [P50AA024337]
FX This study was funded by awards from the National Institutes of Health:
   K01 DK096042, R03 DK107912 to Juliane Beier; and P30DK120531 to
   Satdarshan (Paul) S. Monga. Research was also supported by an
   Institutional Development Award (IDeA) from the National Institute of
   General Medical Sciences of the National Institutes of Health under
   grant number P20GM113226 and the National Institute on Alcohol Abuse and
   Alcoholism of the National Institutes of Health under [P50AA024337]. The
   content is solely the responsibility of the authors and does not
   necessarily represent the official views of the National Institutes of
   Health.
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   WHO (World Health Organization), 2018, ECH
NR 46
TC 7
Z9 8
U1 0
U2 9
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0041-008X
EI 1096-0333
J9 TOXICOL APPL PHARM
JI Toxicol. Appl. Pharmacol.
PD JUL 15
PY 2020
VL 399
AR 115068
DI 10.1016/j.taap.2020.115068
PG 9
WC Pharmacology & Pharmacy; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Toxicology
GA LW1WT
UT WOS:000538937600012
PM 32445754
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Zhang, Q
   Xiao, XH
   Zheng, J
   Li, M
   Yu, M
   Ping, F
   Wang, T
   Wang, XJ
AF Zhang, Qian
   Xiao, Xinhua
   Zheng, Jia
   Li, Ming
   Yu, Miao
   Ping, Fan
   Wang, Tong
   Wang, Xiaojing
TI A Maternal High-Fat Diet Induces DNA Methylation Changes That Contribute
   to Glucose Intolerance in Offspring
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Article
DE DNA methylation; insulin receptor substrate; MAPK; maternal high fat
   diet; epigenetics
ID BODY-MASS INDEX; EPIGENETIC CHANGES; INSULIN-RECEPTOR; IN-UTERO;
   METABOLIC SYNDROME; OXIDATIVE STRESS; SIGNALING SYSTEM;
   APOLIPOPROTEIN-E; GENE-EXPRESSION; DE-NOVO
AB Scope: Overnutrition in utero is a critical contributor to the susceptibility of diabetes by programming, although the exact mechanism is not clear. In this paper, we aimed to study the long-term effect of a maternal high-fat (HF) diet on offspring through epigenetic modifications. Procedures: Five-week-old female C57BL6/J mice were fed a HF diet or control diet for 4 weeks before mating and throughout gestation and lactation. At postnatal week 3, pups continued to consume a HF or switched to a control diet for 5 weeks, resulting in four groups of offspring differing by their maternal and postweaning diets. Results: The maternal HF diet combined with the offspring HF diet caused hyperglycemia and insulin resistance in male pups. Even after changing to the control diet, male pups exposed to the maternal HF diet still exhibited hyperglycemia and glucose intolerance. The livers of pups exposed to a maternal HF diet had a hypermethylated insulin receptor substrate 2 (Irs2) gene and a hypomethylated mitogen-activated protein kinase kinase 4 (Map2k4) gene. Correspondingly, the expression of the Irs2 gene decreased and that of Map2k4 increased in pups exposed to a maternal HF diet. Conclusion: Maternal overnutrition programs long-term epigenetic modifications, namely, Irs2 and Map2k4 gene methylation in the offspring liver, which in turn predisposes the offspring to diabetes later in life.
C1 [Zhang, Qian; Xiao, Xinhua; Zheng, Jia; Li, Ming; Yu, Miao; Ping, Fan; Wang, Tong; Wang, Xiaojing] Chinese Acad Med Sci, Peking Union Med Coll, Peking Union Med Coll Hosp, Key Lab Endocrinol,Minist Hlth,Dept Endocrinol, Beijing, Peoples R China.
C3 Chinese Academy of Medical Sciences - Peking Union Medical College;
   Peking Union Medical College; Peking Union Medical College Hospital
RP Xiao, XH (corresponding author), Chinese Acad Med Sci, Peking Union Med Coll, Peking Union Med Coll Hosp, Key Lab Endocrinol,Minist Hlth,Dept Endocrinol, Beijing, Peoples R China.
EM xiaoxh2014@vip.163.com
RI Li, Ming/I-1323-2018; Qian, Zhang/HHS-7963-2022
OI Zhang, Qian/0000-0001-9846-0141; , Jia/0000-0002-6480-3422
FU National Key R&D Program of China [2017YFC1309603]; National Key
   Research and Development Program of China [2016YFA0101002]; Medical
   Epigenetics Research Center, Chinese Academy of Medical Sciences
   [2017PT31036, 2018PT31021]; Non-profit Central Research Institute Fund
   of Chinese Academy of Medical Sciences [2017PT32020, 2018PT32001];
   National Natural Science Foundation of China [81170736, 81570715,
   81870579, 81870545]; National Natural Science Foundation for Young
   Scholars of China [81300649]; China Scholarship Council foundation
   [201308110443]; PUMC Youth Fund [33320140022]; Fundamental Research
   Funds for the Central Universities; Scientific Activities Foundation for
   Selected Returned Overseas Professionals of Human Resources and Social
   Security Ministry
FX This work was supported by the grants from National Key R&D Program of
   China (2017YFC1309603), National Key Research and Development Program of
   China (2016YFA0101002), Medical Epigenetics Research Center, Chinese
   Academy of Medical Sciences (2017PT31036 and 2018PT31021), the
   Non-profit Central Research Institute Fund of Chinese Academy of Medical
   Sciences (Nos. 2017PT32020 and 2018PT32001), National Natural Science
   Foundation of China (Nos. 81170736, 81570715, 81870579, and 81870545),
   National Natural Science Foundation for Young Scholars of China (No.
   81300649), China Scholarship Council foundation (201308110443), PUMC
   Youth Fund (33320140022), and Fundamental Research Funds for the Central
   Universities, and Scientific Activities Foundation for Selected Returned
   Overseas Professionals of Human Resources and Social Security Ministry.
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NR 84
TC 56
Z9 63
U1 0
U2 10
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD DEC 13
PY 2019
VL 10
AR 871
DI 10.3389/fendo.2019.00871
PG 13
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA JY9JY
UT WOS:000504723600001
PM 31920981
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Kawakami, T
   Nishiyama, K
   Kadota, Y
   Sato, M
   Inoue, M
   Suzuki, S
AF Kawakami, Takashige
   Nishiyama, Kaori
   Kadota, Yoshito
   Sato, Masao
   Inoue, Masahisa
   Suzuki, Shinya
TI Cadmium modulates adipocyte functions in metallothionein-null mice
SO TOXICOLOGY AND APPLIED PHARMACOLOGY
LA English
DT Article
DE Cadmium; Adipose tissue; Metallothionein; Adipokine
ID HORMONE-SENSITIVE LIPASE; LIPID STORAGE DROPLETS; WHITE ADIPOSE-TISSUE;
   DIET-INDUCED OBESITY; WILD-TYPE MICE; INSULIN-RESISTANCE; METABOLIC
   SYNDROME; 3T3-L1 ADIPOCYTES; OXIDATIVE STRESS; EXPRESSION
AB Our previous study has demonstrated that exposure to cadmium (Cd), a toxic heavy metal, causes a reduction of adipocyte size and the modulation of adipokine expression. To further investigate the significance of the Cd action, we studied the effect of Cd on the white adipose tissue (WAT) of metallothionein null (MT-/-) mice, which cannot form atoxic Cd-MT complexes and are used for evaluating Cd as free ions, and wild type (MT+/+) mice. Cd administration more significantly reduced the adipocyte size of MT-/- mice than that of MT+/+ mice. Cd exposure also induced macrophage recruitment to WAT with an increase in the expression level of Ccl2 (MCP-1) in the MT-/- mice. The in vitro exposure of Cd to adipocytes induce triglyceride release into culture medium, decrease in the expression levels of genes involved in fatty acid synthesis and lipid hydrolysis at 24 h, and at 48 h increase in phosphorylation of the lipid-droplet-associated protein perilipin, which facilitates the degradation of stored lipids in adipocytes. Therefore, the reduction in adipocyte size by Cd may arise from an imbalance between lipid synthesis and lipolysis. In addition, the expression levels of leptin, adiponectin and resistin decreased in adipocytes. Taken together, exposure to Cd may induce unusually small adipocytes and modulate the expression of adipokines differently from the case of physiologically small adipocytes, and may accelerate the risk of developing insulin resistance and type 2 diabetes. (C) 2013 Published by Elsevier Inc.
C1 [Kawakami, Takashige; Nishiyama, Kaori; Kadota, Yoshito; Sato, Masao; Inoue, Masahisa; Suzuki, Shinya] Tokushima Bunri Univ, Fac Pharmaceut Sci, Tokushima 7708514, Japan.
C3 Tokushima Bunri University
RP Suzuki, S (corresponding author), Tokushima Bunri Univ, Fac Pharmaceut Sci, 180 Yamashiro Cho, Tokushima 7708514, Japan.
EM suzukis@ph.bunri-u.ac.jp
OI Kadota, Yoshito/0000-0002-2721-4100
FU MEXT KAKENHI [21590144]; JSPS KAKENHI [24590771, 22790139]; Open
   Research Center Fund for Promotion; Grants-in-Aid for Scientific
   Research [22790139, 21590144, 24590771] Funding Source: KAKEN
FX This research was partially supported by MEXT KAKENHI Grant Number
   21590144 (to M.S.), JSPS KAKENHI Grant Number 24590771 (to TX), and JSPS
   KAKENHI Grant Number 22790139 (to Y.K.), and by the Open Research Center
   Fund for Promotion. All authors contributed equally to this work
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NR 49
TC 46
Z9 52
U1 0
U2 11
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0041-008X
EI 1096-0333
J9 TOXICOL APPL PHARM
JI Toxicol. Appl. Pharmacol.
PD NOV 1
PY 2013
VL 272
IS 3
BP 625
EP 636
DI 10.1016/j.taap.2013.07.015
PG 12
WC Pharmacology & Pharmacy; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Toxicology
GA 241BM
UT WOS:000326141400008
PM 23921151
DA 2025-06-11
ER

PT J
AU St-Denis, C
   Cloutier, I
   Tanguay, JF
AF St-Denis, Corinne
   Cloutier, Isabelle
   Tanguay, Jean-Francois
TI Key Fatty Acid Combinations Define Vascular Smooth Muscle Cell
   Proliferation and Viability
SO LIPIDS
LA English
DT Article
DE Free fatty acids; Vascular smooth muscle cells; Insulin; Apoptosis; Cell
   viability; Atherosclerosis; Type 2 diabetes
ID ENDOPLASMIC-RETICULUM STRESS; ALPHA-LINOLENIC ACID; PRIMARY RAT
   HEPATOCYTES; ADIPOSE-TISSUE; ENDOTHELIAL DYSFUNCTION;
   CARDIOVASCULAR-DISEASE; MEDITERRANEAN DIET; INSULIN-RESISTANCE; MEDIATED
   APOPTOSIS; METABOLIC SYNDROME
AB High plasma concentrations of free fatty acids (FFA) and insulin are common features in atherosclerotic patients with type 2 diabetes. FFA, according to their nature, can have various effects on vascular smooth muscle cells (VSMC). These cells play important roles throughout atherosclerosis pathogenesis, from plaque development to plaque instability. Thus, this study aims to assess the impact of two FFA combinations and insulin on murine VSMC viability. The two combinations contain the same FFA but at different ratios, one being richer in saturated fatty acids (SFA) and the other having a higher proportion of monounsaturated fatty acids (MUFA). Both combinations inhibited VSMC proliferation due to their pro-apoptotic potential, with SFA being the major inducers of apoptosis. However, the presence of oleic acid (OLA) attenuated this impact in a dose-dependent manner. OLA had also the capacity to reduce apoptosis rates more strongly when combined with a SFA than when used alone in VSMC treatments. This effect was significant only for specific proportions of these FFA and was even more effective in presence of insulin. These results highlight the presence of a competition between pro-apoptotic and anti-apoptotic mechanisms in VSMC that is dependent on FFA ratios (saturated vs. monounsaturated) and on insulinemia. They also underline the importance of the presence of MUFA such as OLA in diets containing high proportions of SFA.
C1 [St-Denis, Corinne; Cloutier, Isabelle; Tanguay, Jean-Francois] Montreal Heart Inst, Res Ctr, Montreal, PQ H1T 1C8, Canada.
   [St-Denis, Corinne; Tanguay, Jean-Francois] Univ Montreal, Fac Med, Montreal, PQ H3T 1J4, Canada.
C3 Universite de Montreal; Universite de Montreal
RP Tanguay, JF (corresponding author), Montreal Heart Inst, Res Ctr, 5000 Belanger St, Montreal, PQ H1T 1C8, Canada.
EM isabelle.cloutier@icm-mhi.org; jean-francois.tanguay@icm-mhi.org
FU Montreal Heart Institute Foundation
FX We would like to thank Dr. Christine Des Rosiers's team for their advice
   on the preparation of fatty acid solutions. This work was supported by a
   grant from the Montreal Heart Institute Foundation to Dr. Jean-Francois
   Tanguay. Corinne St-Denis was supported by a training grant for graduate
   studies from the Montreal Heart Institute Foundation and by excellence
   and writing grants from the Medicine and the Postdoctoral and Superior
   Studies Faculties of Universite de Montreal.
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NR 44
TC 5
Z9 5
U1 0
U2 6
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0024-4201
J9 LIPIDS
JI Lipids
PD NOV
PY 2012
VL 47
IS 11
BP 1073
EP 1084
DI 10.1007/s11745-012-3718-6
PG 12
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA 025XD
UT WOS:000310229400006
PM 23077001
DA 2025-06-11
ER

PT J
AU Agarwal, A
   Banerjee, A
   Banerjee, UC
AF Agarwal, Amit
   Banerjee, Avik
   Banerjee, U. C.
TI Xanthine oxidoreductase: A journey from purine metabolism to
   cardiovascular excitation-contraction coupling
SO CRITICAL REVIEWS IN BIOTECHNOLOGY
LA English
DT Review
DE Xanthine oxidoreductase; cardiovascular disorder; antitumor effect;
   reactive oxygen species; allopurinol; excitation-contraction coupling
ID CHRONIC HEART-FAILURE; ISCHEMIA-REPERFUSION INJURY; NITRIC-OXIDE
   SYNTHASE; MYOCARDIAL OXYGEN-CONSUMPTION; FREE-RADICAL GENERATION; TUMOR
   LYSIS SYNDROME; DEHYDROGENASE TYPE D; URIC-ACID; ENDOTHELIAL
   DYSFUNCTION; OXIDATIVE STRESS
AB Xanthine oxidoreductase (XOR) is a ubiquitous complex cytosolic molybdoflavoprotein which controls the rate limiting step of purine catabolism by converting xanthine to uric acid. It is known that optimum concentrations of uric acid (UA) and reactive oxygen species (ROS) are necessary for normal functioning of the body. The ability of XOR to perform detoxification reactions, and to synthesize UA and reactive oxygen species (ROS) makes it a versatile intraand extra-cellular protective "housekeeping enzyme". It is also an important component of the innate immune system. The enzyme is a target of drugs against gout and hyperuricemia and the protein is of major interest as it is associated with ischemia reperfusion (I/R) injury, vascular disorders in diabetes, cardiovascular disorders, adipogenesis, metabolic syndrome, cancer, and many other disease conditions. Xanthine oxidoreductase in conjugation with antibodies has been shown to have an anti-tumor effect due to its ability to produce ROS, which in turn reduces the growth of cancer tissues. Apart from this, XOR in association with nitric oxide synthase also participates in myocardial excitation-contraction coupling. Although XOR was discovered over 100 years ago, its physiological and pathophysiological roles are still not clearly elucidated. In this review, various physiological and pathophysiological functional aspects of XOR and its association with various forms of cancer are discussed in detail.
C1 [Agarwal, Amit; Banerjee, U. C.] Natl Inst Pharmaceut Educ & Res, Dept Pharmaceut Technol Biotechnol, Sas Nagar, Punjab, India.
   [Banerjee, Avik] Govt Med Coll, Patiala, Punjab, India.
C3 National Institute of Pharmaceutical Education & Research, S.A.S. Nagar
   (Mohali)
RP Banerjee, UC (corresponding author), Natl Inst Pharmaceut Educ & Res, Dept Pharmaceut Technol Biotechnol, Sect 67, Sas Nagar, Punjab, India.
EM ucbanerjee@niper.ac.in
RI Agarwal, Amit/G-8580-2011
OI Banerjee, uttam Chand/0000-0002-7363-4042
FU Department of Biotechnology, Government of India
FX A.A. gratefully acknowledges the Department of Biotechnology, Government
   of India, for providing the senior research fellowship to carry out the
   work.
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NR 220
TC 69
Z9 79
U1 0
U2 27
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0738-8551
EI 1549-7801
J9 CRIT REV BIOTECHNOL
JI Crit. Rev. Biotechnol.
PD SEP
PY 2011
VL 31
IS 3
BP 264
EP 280
DI 10.3109/07388551.2010.527823
PG 17
WC Biotechnology & Applied Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology
GA 809LO
UT WOS:000294057500005
PM 21774633
DA 2025-06-11
ER

PT J
AU Kjollesdal, MKR
   Hjellset, VT
   Bjorge, B
   Holmboe-Ottesen, G
   Wandel, M
AF Kjollesdal, Marte K. Raberg
   Hjellset, Victoria T.
   Bjorge, Benedikte
   Holmboe-Ottesen, Gerd
   Wandel, Margareta
TI Perceptions of risk factors for diabetes among Norwegian-Pakistani women
   participating in a culturally adapted intervention
SO ETHNICITY & HEALTH
LA English
DT Article
DE Pakistani; immigrant; diabetes; risk factor; intervention
ID LIFE-STYLE INTERVENTION; BODY-MASS INDEX; ETHNIC-DIFFERENCES; METABOLIC
   SYNDROME; CONTROLLED-TRIAL; HISPANIC ADULTS; HEART-DISEASE; WEIGHT-LOSS;
   TYPE-2; PREVENTION
AB Objective. To explore perceptions of diabetes risk factors among Pakistani immigrant women, as part of their explanatory model of the disease, and the changes in these perceptions after a culturally adapted intervention.
   Design. Intervention study, carried out in Oslo, Norway, comprising 198 women.
   Results. At baseline, about 75% of the women perceived sugar to be a risk factor for diabetes, about 30% mentioned physical inactivity and stress and close to 20% mentioned overweight. Twelve per cent could not identify any risk factors. When asked about foods to include in a diet to prevent diabetes, vegetables were mentioned by 45%, while 33% did not know any foods to include. Among those attending >= 60% of the educational sessions, the proportions mentioning little physical activity (p < 0.001), overweight (p = 0.001) and family history (p = 0.007) as risk factors increased. Furthermore, the proportions mentioning legumes (p = 0.001), fish (p < 0.001), fibre (p = 0.035) or vegetables (p = 0.015) as important in a diet to prevent diabetes increased, and the proportion not knowing any food to include was reduced to 10% (p = 0.004). Except for little physical activity, similar changes in responses were not registered in the control group.
   Conclusions. There is a need for improved knowledge about diabetes prevention among Pakistani immigrant women, and a culturally adapted intervention may contribute to this.
C1 [Kjollesdal, Marte K. Raberg; Bjorge, Benedikte; Wandel, Margareta] Univ Oslo, Inst Basic Med Sci, Dept Nutr, N-0316 Oslo, Norway.
   [Hjellset, Victoria T.; Holmboe-Ottesen, Gerd] Univ Oslo, Inst Hlth & Soc, Dept Gen Practice & Community Med, N-0318 Oslo, Norway.
C3 University of Oslo; University of Oslo
RP Kjollesdal, MKR (corresponding author), Univ Oslo, Inst Basic Med Sci, Dept Nutr, Pb 1046, N-0316 Oslo, Norway.
EM m.k.raberg@medisin.uio.no
RI Kjollesdal, Marte Karoline Raberg/GWM-4858-2022
OI Kjollesdal, Marte Karoline Raberg/0000-0002-5223-711X
FU Norwegian Research Council [166977/v50]; Throne Holst Foundation [2875];
   Jahre Foundation
FX The work was supported by the Norwegian Research Council (166977/v50),
   the Throne Holst Foundation (2875) and the Jahre Foundation. Margareta
   Wandel and Gerd Holmboe-Ottesen planned and supervised the project.
   Benedikte Bjorge and Victoria T. Hjellset conducted the intervention and
   coordinated data collection. Marte K. Raberg Kjollesdal did the
   statistical analyses and the drafting of the article. All authors
   contributed in the final stage of the writing. We thank Monica Morris,
   Aisha Ali, Anica Munir, Marianne Lunde and Eva Kristiansen for their
   contribution in coordination and collection of data. We also thank all
   the participating women who gave us their time and shared their
   knowledge and experiences with us. Reebok provided walking shoes.
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NR 65
TC 15
Z9 18
U1 0
U2 9
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 1355-7858
EI 1465-3419
J9 ETHNIC HEALTH
JI Ethn. Health
PY 2011
VL 16
IS 3
BP 279
EP 297
DI 10.1080/13557858.2011.573537
PG 19
WC Ethnic Studies; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Ethnic Studies; Public, Environmental & Occupational Health
GA 775MH
UT WOS:000291463100007
PM 21660786
DA 2025-06-11
ER

PT J
AU van Ginneken, V
   Sitnyakowsky, L
   Jeffery, JE
AF van Ginneken, Vincent
   Sitnyakowsky, Laura
   Jeffery, Jonathan E.
TI Infectobesity: viral infections (especially with human adenovirus-36:
   Ad-36) may be a cause of obesity
SO MEDICAL HYPOTHESES
LA English
DT Article
ID METABOLIC SYNDROME; NATIONAL-HEALTH; US ADULTS; PREVALENCE; OVERWEIGHT;
   ADIPOSITY; DISEASE; ASSOCIATION; EXPRESSION; MORTALITY
AB In recent years viral infections have been recognized as possible cause of obesity, alongside the traditionally recognized causes (genetic inheritance, and behaviour/environmental causes such as diet exercise, cultural practices and stress). Although four viruses have been reported to induce obesity (infectoobesity) in animal models (chickens, mice, sheep, goat, dogs, rats and hamsters), until recently the viral etiology of human obesity has not received sufficient attention, possibly because the four viruses are not able to infect humans. In a series of papers over the last ten years, however, the group of Prof. Dhurandhar (Pennington Biomedical Research Center, LA, USA) demonstrated that a human adenovirus, adenovirus-36 (Ad-36), is capable of inducing adiposity in experimentally infected chickens, mice and non-human primates (marmosets). Ad-36 is known to increase the replication, differentiation, lipid accumulation and insulin sensitivity in fat cells and reduces those cells' leptin secretion and expression. It also affects human primary preadipocytes. In rats increased adiposity was observed due to Ad-36 infection. Recent studies have shown that, in the USA, antibodies to Ad-36 were more prevalent in obese subjects (30%) than in non-obese subjects (11%). We postulate that Ad-36 may be a contributing factor to the worldwide rising problem of obesity. We Suggest the extension of comparative virological studies between North America and Europe, and studies between discordant twins (both dizygous and monozygous). (C) 2008 Elsevier Ltd. All rights reserved.
C1 [van Ginneken, Vincent] Wageningen UR, Plant Res Int, Agrosyst Res, NL-6700 AA Wageningen, Netherlands.
   [Sitnyakowsky, Laura] Leiden Univ, Med Ctr, Dept Anat & Embryol, NL-2300 RC Leiden, Netherlands.
   [Jeffery, Jonathan E.] Int Sch Amsterdam, NL-1184 TB Amstelveen, Netherlands.
C3 Wageningen University & Research; Leiden University - Excl LUMC; Leiden
   University; Leiden University Medical Center (LUMC)
RP van Ginneken, V (corresponding author), Wageningen UR, Plant Res Int, Agrosyst Res, POB 16, NL-6700 AA Wageningen, Netherlands.
EM Vincent.vanginneken@wur.nl
FU Center for Medical Systems Biology (CMSB); Leiden University; Plant
   Research International; Agrosystems Research, Wageningen University
FX This study was supported by grants of Center for Medical Systems Biology
   (CMSB), Leiden University and Plant Research International, Agrosystems
   Research, Wageningen University. We thank Nik Dhurandhar, PhD, Associate
   Professor, Department of Infections and Obesity, Pennington Biomedical
   Research Center, Louisiana State University System for helpful
   suggestions.
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NR 36
TC 30
Z9 34
U1 0
U2 16
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0306-9877
EI 1532-2777
J9 MED HYPOTHESES
JI Med. Hypotheses
PD APR
PY 2009
VL 72
IS 4
BP 383
EP 388
DI 10.1016/j.mehy.2008.11.034
PG 6
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 425EM
UT WOS:000264619800005
PM 19138827
DA 2025-06-11
ER

PT J
AU Podraza, J
   Gutowska, K
   Lenartowicz, A
   Wasowski, M
   Jonas, MI
   Bartoszewicz, Z
   Lisik, W
   Jonas, M
   Binda, A
   Jaworski, P
   Tarnowski, W
   Noszczyk, B
   Puzianowska-Kuznicka, M
   Kurylowicz, A
AF Podraza, Jakub
   Gutowska, Klaudia
   Lenartowicz, Anna
   Wasowski, Michal
   Jonas, Marta Izabela
   Bartoszewicz, Zbigniew
   Lisik, Wojciech
   Jonas, Maurycy
   Binda, Artur
   Jaworski, Pawel
   Tarnowski, Wieslaw
   Noszczyk, Bartlomiej
   Puzianowska-Kuznicka, Monika
   Kurylowicz, Alina
TI The Role of microRNA in the Regulation of Cortisol Metabolism in the
   Adipose Tissue in the Course of Obesity
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE cortisol metabolism; glucocorticoid receptor alpha; obesity; adipose
   tissue; microRNA; metabolic inflammation
ID 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1; GLUCOCORTICOID-RECEPTOR;
   WEIGHT-LOSS; 11-BETA-HSD1; MARKERS; STRESS
AB The similarity of the clinical picture of metabolic syndrome and hypercortisolemia supports the hypothesis that obesity may be associated with impaired expression of genes related to cortisol action and metabolism in adipose tissue. The expression of genes encoding the glucocorticoid receptor alpha (GR), cortisol metabolizing enzymes (HSD11B1, HSD11B2, H6PDH), and adipokines, as well as selected microRNAs, was measured by real-time PCR in adipose tissue from 75 patients with obesity, 19 patients following metabolic surgery, and 25 normal-weight subjects. Cortisol levels were analyzed by LC-MS/MS in 30 pairs of tissues. The mRNA levels of all genes studied were significantly (p < 0.05) decreased in the visceral adipose tissue (VAT) of patients with obesity and normalized by weight loss. In the subcutaneous adipose tissue (SAT), GR and HSD11B2 were affected by this phenomenon. Negative correlations were observed between the mRNA levels of the investigated genes and selected miRNAs (hsa-miR-142-3p, hsa-miR-561, and hsa-miR-579). However, the observed changes did not translate into differences in tissue cortisol concentrations, although levels of this hormone in the SAT of patients with obesity correlated negatively with mRNA levels for adiponectin. In conclusion, although the expression of genes related to cortisol action and metabolism in adipose tissue is altered in obesity and miRNAs may be involved in this process, these changes do not affect tissue cortisol concentrations.
C1 [Podraza, Jakub] Warsaw Univ Life Sci, Fac Biol & Biotechnol, PL-02787 Warsaw, Poland.
   [Gutowska, Klaudia] Warsaw Med Univ, Dept Obstet & Gynecol 2, PL-00315 Warsaw, Poland.
   [Lenartowicz, Anna] LabExperts Lab, PL-93519 Lodz, Poland.
   [Wasowski, Michal; Kurylowicz, Alina] Med Ctr Postgrad Educ, Dept Gen Med & Geriatr Cardiol, PL-00401 Warsaw, Poland.
   [Jonas, Marta Izabela; Puzianowska-Kuznicka, Monika; Kurylowicz, Alina] Polish Acad Sci, Mossakowski Med Res Ctr, Dept Human Epigenet, PL-02106 Warsaw, Poland.
   [Bartoszewicz, Zbigniew] Med Univ Warsaw, Dept Internal Med & Endocrinol, PL-02097 Warsaw, Poland.
   [Lisik, Wojciech] Med Univ Warsaw, Dept Gen & Transplantat Surg, PL-00694 Warsaw, Poland.
   [Jonas, Maurycy] Barska Hosp, Dept Gen Surg, PL-02315 Warsaw, Poland.
   [Binda, Artur; Jaworski, Pawel; Tarnowski, Wieslaw] Med Ctr Postgrad Educ, Dept Gen Oncol & Bariatr Surg, PL-00401 Warsaw, Poland.
   [Noszczyk, Bartlomiej] Med Ctr Postgrad Educ, Dept Plast Surg, PL-00401 Warsaw, Poland.
   [Puzianowska-Kuznicka, Monika] Med Ctr Postgrad Educ, Dept Geriatr & Gerontol, PL-01826 Warsaw, Poland.
C3 Warsaw University of Life Sciences; Medical University of Warsaw; Centre
   of Postgraduate Medical Education - Poland; Polish Academy of Sciences;
   Mossakowski Medical Research Institute of the Polish Academy of
   Sciences; Medical University of Warsaw; Medical University of Warsaw;
   Centre of Postgraduate Medical Education - Poland; Centre of
   Postgraduate Medical Education - Poland; Centre of Postgraduate Medical
   Education - Poland
RP Kurylowicz, A (corresponding author), Med Ctr Postgrad Educ, Dept Gen Med & Geriatr Cardiol, PL-00401 Warsaw, Poland.; Kurylowicz, A (corresponding author), Polish Acad Sci, Mossakowski Med Res Ctr, Dept Human Epigenet, PL-02106 Warsaw, Poland.
EM jakub.podraza@gmail.com; klaudia.gutowska@wum.edu.pl;
   anna.lenartowicz@labexperts.com.pl; mwasowski@cmkp.edu.pl;
   martajonas@imdik.pan.pl; z.bartoszewicz@wum.edu.pl;
   wojciech.lisik@wum.edu.pl; morjon@poczta.onet.pl;
   arturbinda@cmkp.edu.pl; pjaworski@cmkp.edu.pl; wtarnowski@cmkp.edu.pl;
   bnoszczyk@melilot.pl; mpuzianowska@imdik.pan.pl;
   akurylowicz@imdik.pan.pl
RI Jaworski, Paweł/AFP-7497-2022; Kuryłowicz, Alina/ABY-3541-2022; Lisik,
   Wojciech/Q-8972-2018
OI Wasowski, Michal/0000-0003-3707-0419; Gutowska,
   Klaudia/0000-0002-1291-0920; Kurylowicz, Alina/0000-0001-8632-4927;
   Puzianowska-Kuznicka, Monika/0000-0001-5295-3848; Podraza,
   Jakub/0009-0001-7278-6386; Lisik, Wojciech/0000-0003-3020-3979
FU National Science Centre Poland
FX No Statement Available
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NR 38
TC 2
Z9 2
U1 0
U2 3
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD MAY
PY 2024
VL 25
IS 10
AR 5058
DI 10.3390/ijms25105058
PG 15
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA SM2L1
UT WOS:001234803100001
PM 38791098
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Parker, J
AF Parker, Jim
TI Pathophysiological Effects of Contemporary Lifestyle on
   Evolutionary-Conserved Survival Mechanisms in Polycystic Ovary Syndrome
SO LIFE-BASEL
LA English
DT Review
DE polycystic ovary syndrome; evolution; inflammation; insulin resistance;
   hyperinsulinemia; immune; infertility; endocrine disrupting chemicals;
   environment; microbiome; lifestyle; diet
ID GLYCATION END-PRODUCTS; PATTERN-RECOGNITION RECEPTORS;
   SYMPATHETIC-NERVOUS-SYSTEM; VISCERAL ADIPOSE-TISSUE; REGULATORY T-CELLS;
   INSULIN-RESISTANCE; GUT MICROBIOTA; SYNDROME PCOS; BISPHENOL-A;
   ENDOCRINE DISRUPTORS
AB Polycystic ovary syndrome (PCOS) is increasingly being characterized as an evolutionary mismatch disorder that presents with a complex mixture of metabolic and endocrine symptoms. The Evolutionary Model proposes that PCOS arises from a collection of inherited polymorphisms that have been consistently demonstrated in a variety of ethnic groups and races. In utero developmental programming of susceptible genomic variants are thought to predispose the offspring to develop PCOS. Postnatal exposure to lifestyle and environmental risk factors results in epigenetic activation of developmentally programmed genes and disturbance of the hallmarks of health. The resulting pathophysiological changes represent the consequences of poor-quality diet, sedentary behaviour, endocrine disrupting chemicals, stress, circadian disruption, and other lifestyle factors. Emerging evidence suggests that lifestyle-induced gastrointestinal dysbiosis plays a central role in the pathogenesis of PCOS. Lifestyle and environmental exposures initiate changes that result in disturbance of the gastrointestinal microbiome (dysbiosis), immune dysregulation (chronic inflammation), altered metabolism (insulin resistance), endocrine and reproductive imbalance (hyperandrogenism), and central nervous system dysfunction (neuroendocrine and autonomic nervous system). PCOS can be a progressive metabolic condition that leads to obesity, gestational diabetes, type two diabetes, metabolic-associated fatty liver disease, metabolic syndrome, cardiovascular disease, and cancer. This review explores the mechanisms that underpin the evolutionary mismatch between ancient survival pathways and contemporary lifestyle factors involved in the pathogenesis and pathophysiology of PCOS.
C1 [Parker, Jim] Univ Wollongong, Sch Med, Wollongong, NSW 2522, Australia.
C3 University of Wollongong
RP Parker, J (corresponding author), Univ Wollongong, Sch Med, Wollongong, NSW 2522, Australia.
EM jimparker@ozemail.com.au
RI parker, jim/AAD-3199-2022
OI Parker, Jim/0000-0002-5018-5555
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NR 292
TC 16
Z9 17
U1 5
U2 27
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2075-1729
J9 LIFE-BASEL
JI Life-Basel
PD APR
PY 2023
VL 13
IS 4
AR 1056
DI 10.3390/life13041056
PG 35
WC Biology; Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics; Microbiology
GA F5ZN6
UT WOS:000983126600001
PM 37109585
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Granak, K
   Vnucak, M
   Beliancinova, M
   Pytliakova, M
   Dedinska, I
AF Granak, Karol
   Vnucak, Matej
   Beliancinova, Monika
   Pytliakova, Margareta
   Dedinska, Ivana
TI Hyperleptinemia as a risk factor for post-transplant diabetes mellitus
   development after kidney transplantation
SO BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY
LA English
DT Article
DE adipocytokines; interleukins; post-transplant diabetes mellitus; kidney
   transplantation; leptin
ID INTERLEUKIN-10 IL-10; INSULIN-RESISTANCE; GENE POLYMORPHISMS; METABOLIC
   SYNDROME; OXIDATIVE STRESS; ADIPONECTIN; ASSOCIATION; INFLAMMATION;
   OBESITY; LEPTIN
AB INTRODUCTION: Adipose tissue is involved in the synthesis of hormones that have an impact on food intake regulation, control of insulin sensitivity or regulation of inflammatory processes. The aim of this study was to determine the importance of adipocytokines and interleukins levels for the development of post-transplant diabetes mellitus (PTDM) after kidney transplantation (KT). MATERIAL AND METHODS: In the prospective analysis, the studied sample (n = 104) was divided into the control group, prediabetes group and PTDM group. Prior to transplantation, and subsequently, at 3, 6 and 12 months after KT, we recorded the basic characteristics of the donor and recipient, including parameters reflecting graft function, metabolic and anthropometric parameters. At the same time, we monitored the levels of adiponectin, leptin and interleukins during the monitored period. RESULTS: Using multivariate logistic regression, we identified hyperleptinemia 12 months after KT as an independent risk factor for PTDM development 1 year after KT [OR 1.0320; 95% Cl 0.9785???1.0884 (p=0.0038)]. At the same time, we confirmed that age at the time of KT is also an independent risk factor for PTDM [OR 1.0903; 95% Cl 1.0149???1.1714 (p=0.0180)]. CONCLUSION: We confirmed that elevated leptin level 12 months after KT is associated with the development of PTDM (Tab. 3, Fig. 4, Ref. 22). Text in PDF www.elis.sk
C1 [Granak, Karol; Vnucak, Matej; Beliancinova, Monika; Pytliakova, Margareta; Dedinska, Ivana] Univ Hosp Martin, Transplant Ctr, Kollarova 2, SK-03601 Martin, Slovakia.
   [Granak, Karol; Vnucak, Matej; Beliancinova, Monika; Dedinska, Ivana] Comenius Univ, Jessenius Med Fac, Transplant Ctr, Univ Hosp Martin, Martin, Slovakia.
   [Granak, Karol; Beliancinova, Monika; Dedinska, Ivana] Comenius Univ, Clin Internal Med 1, Jessenius Med Fac, Martin, Slovakia.
   [Pytliakova, Margareta] Comenius Univ, Clin Gastrointestinal Internal Med, Univ Hosp Martin, Jessenius Med Fac, Martin, Slovakia.
C3 Comenius University Bratislava; Comenius University Bratislava; Comenius
   University Bratislava
RP Vnucak, M (corresponding author), Univ Hosp Martin, Transplant Ctr, Kollarova 2, SK-03601 Martin, Slovakia.
EM vnucak.matej@gmail.com
RI Vnučák, Matej/JEZ-3193-2023; Dedinska, Ivana/X-6042-2018
FU  [VEGA-1/0238/21]
FX This study was supported by grant VEGA-1/0238/21: Continual glucose
   monitoring and glycemic variability in early post-transplantation period
   as a predictor of complications after kidney transplantation.
CR Arita Y, 2012, BIOCHEM BIOPH RES CO, V425, P560, DOI 10.1016/j.bbrc.2012.08.024
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NR 22
TC 2
Z9 2
U1 0
U2 1
PU AEPRESS SRO
PI BRATISLAVA
PA BAJZOVA 7, BRATISLAVA, 821 08, SLOVAKIA
SN 0006-9248
EI 1336-0345
J9 BRATISL MED J
JI Bratisl. Med. J.
PY 2022
VL 123
IS 8
BP 573
EP 578
DI 10.4149/BLL_2022_092
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 3M6NW
UT WOS:000835577200010
PM 35852508
OA gold
DA 2025-06-11
ER

PT J
AU Taher, R
   Sara, JD
   Toya, T
   Shepherd, R
   Moder, K
   Lerman, LO
   Lerman, A
AF Taher, Riad
   Sara, Jaskanwal D.
   Toya, Takumi
   Shepherd, Roger
   Moder, Kevin
   Lerman, Lilach O.
   Lerman, Amir
TI Secondary Raynaud's phenomenon is associated with microvascular
   peripheral endothelial dysfunction
SO MICROVASCULAR RESEARCH
LA English
DT Article
DE Endothelial dysfunction; Raynaud's phenomenon; Vascular health;
   Cardiovascular disease; Novel risk factor
ID SYSTEMIC-SCLEROSIS; METABOLIC-SYNDROME; MENTAL STRESS; NITRIC-OXIDE;
   DAMAGE; PREDICTORS; TRANSITION
AB Previous studies in patients with Raynaud's phenomenon (RP) have found an association between microvascular abnormalities assessed by nail fold capillaroscopy and macrovascular peripheral endothelial dysfunction (PED), but the association between RP and nitric oxide related (NO) microvascular PED is not yet established. We performed a retrospective cross-sectional analysis of patients who were referred to Mayo Clinic between 2006 and 2014 for routine cardiovascular evaluation and who underwent evaluation of Reactive Hyperemia Peripheral Arterial Tonometry (index < 2 consistent with PED). Identification of the presence of RP was determined by retrospective chart review. Six hundred sixty six individuals were included in this study (mean age 51.9 +/- 13.5 years, 411 (61.3%) women), 637 (95.1%) individuals did not have RP (control group), and 29 (4.3%) had secondary RP. Only 4 patients had primary RP and were thus excluded from the final analyses. In a multivariate analysis adjusting for age, sex, smoking status, and use of statins we found a significant association between secondary RP and microvascular PED in all patients (Odds ratio: 2.45; 95% confidence interval 1.13-5.34; P = 0.0236) that remained significant in women after stratifying by sex. Secondary RP is associated with microvascular PED, detected using a non-invasive NO-dependent method. Early detection of microvascular PED could help in identifying individuals with secondary RP who are at risk for developing connective tissue disease as well as CVD.
C1 [Taher, Riad; Sara, Jaskanwal D.; Toya, Takumi; Shepherd, Roger; Lerman, Amir] Mayo Clin, Div Cardiovasc Dis, Coll Med & Sci, Rochester, MN USA.
   [Moder, Kevin] Mayo Clin, Dept Med, Div Rheumatol, Coll Med & Sci, Rochester, MN USA.
   [Lerman, Lilach O.] Mayo Clin, Dept Med, Div Nephrol & Hypertens, Coll Med & Sci, Rochester, MN USA.
C3 Mayo Clinic; Mayo Clinic; Mayo Clinic
RP Lerman, A (corresponding author), 200 1st St SW, Rochester, MN 55906 USA.
EM lerman.amir@mayo.edu
RI Lerman, Lilach/M-4962-2017
OI Taher, Riad/0000-0002-7419-0498; Toya, Takumi/0000-0002-4681-2798
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NR 38
TC 9
Z9 9
U1 0
U2 2
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0026-2862
EI 1095-9319
J9 MICROVASC RES
JI Microvasc. Res.
PD NOV
PY 2020
VL 132
AR 104040
DI 10.1016/j.mvr.2020.104040
PG 6
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA OD0DZ
UT WOS:000579526400003
PM 32768463
DA 2025-06-11
ER

PT J
AU Caito, SW
   Newell-Caito, J
   Martell, M
   Crawford, N
   Aschner, M
AF Caito, Samuel W.
   Newell-Caito, Jennifer
   Martell, Megan
   Crawford, Nicole
   Aschner, Michael
TI Methylmercury Induces Metabolic Alterations in Caenorhabditis
   elegans: Role for C/EBP Transcription Factor
SO TOXICOLOGICAL SCIENCES
LA English
DT Article
DE methylmercury; C/EBP; cebp-1; lipid homeostasis
ID MITOTIC CLONAL EXPANSION; IN-VITRO UPTAKE; C. ELEGANS; ADIPOCYTE
   DIFFERENTIATION; FAT ACCUMULATION; METHYL MERCURY; BODY-WEIGHT;
   EXPOSURE; GLUTAMATE; EXPRESSION
AB Methylmercury (MeHg) is a well-known neurotoxicant; however, its role in metabolic diseases has been gaining wider attention. We have previously shown that MeHg causes metabolic alterations in Caenorhabditis elegans, leading to decreased nicotinamide adenine dinucleotide cofactor, mitochondrial dysfunction, and oxidative stress. We were, therefore, interested in whether MeHg also affects nutrient metabolism, particularly lipid homeostasis, which may contribute to the development of metabolic conditions such as obesity or metabolic syndrome (MS). RNA from wild-type worms exposed to MeHg was collected immediately after treatment and used for gene expression analysis by DNA microarray. MeHg differentially regulated 215 genes, 17 genes involved in lipid homeostasis, and 12 genes involved in carbohydrate homeostasis. Of particular interest was cebp-1, the worm ortholog to human C/EBP, a pro-adipogenic transcription factor implicated in MS. MeHg increased the expression of cebp-1 as well as pro-adipogenic transcription factors sbp-1 and nhr-49, triglyceride synthesis enzyme acl-6, and lipid transport proteins vit-2 and vit-6. Concurrent with the altered gene expression, MeHg increased triglyceride levels, lipid storage, and feeding behaviors. Worms expressing mutant cebp-1 were protected from MeHg-induced alterations in lipid content, feeding behaviors, and gene expression, highlighting the importance of this transcription factor in the worm's response to MeHg. Taken together, our data demonstrate that MeHg induces biochemical, metabolic, and behavioral changes in C. elegans that can lead to metabolic dysfunction.
C1 [Caito, Samuel W.; Martell, Megan; Crawford, Nicole] Husson Univ, Sch Pharm, Dept Basic Pharmaceut Sci, 1 Coll Cir, Bangor, ME 04401 USA.
   [Newell-Caito, Jennifer] Univ Maine, Dept Mol & Biomed Sci, Orono, ME 04469 USA.
   [Aschner, Michael] Albert Einstein Coll Med, Dept Mol Pharmacol, Bronx, NY 10461 USA.
C3 Husson University; University of Maine System; University of Maine
   Orono; Montefiore Medical Center; Albert Einstein College of Medicine;
   Yeshiva University
RP Caito, SW (corresponding author), Husson Univ, Sch Pharm, Dept Basic Pharmaceut Sci, 1 Coll Cir, Bangor, ME 04401 USA.
EM caitos@husson.edu
RI Crawford, Nicole/Q-7429-2019; Aschner, Michael/ACO-6461-2022
OI Newell-Caito, Jennifer/0000-0003-0981-9736
FU NIEHS [R01 ES007331, R01 ES020852]; Husson University School of Pharmacy
FX NIEHS R01 ES007331 and NIEHS R01 ES020852 (MA), and Husson University
   School of Pharmacy Research Grant (S.W.C.).
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NR 87
TC 10
Z9 10
U1 2
U2 24
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1096-6080
EI 1096-0929
J9 TOXICOL SCI
JI Toxicol. Sci.
PD MAR
PY 2020
VL 174
IS 1
BP 112
EP 123
DI 10.1093/toxsci/kfz244
PG 12
WC Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Toxicology
GA LR4UE
UT WOS:000535691100011
PM 31851340
OA Green Published
DA 2025-06-11
ER

PT J
AU Chen, SH
   Yuan, KC
   Lee, YC
   Shih, CK
   Tseng, SH
   Tinkov, AA
   Skalny, AV
   Chang, JS
AF Chen, Seu-Hwa
   Yuan, Kuo-Ching
   Lee, Yu-Chieh
   Shih, Chun-Kuang
   Tseng, Sung-Hui
   Tinkov, Alexey A.
   Skalny, Anatoly V.
   Chang, Jung-Su
TI Iron and Advanced Glycation End Products: Emerging Role of Iron in
   Androgen Deficiency in Obesity
SO ANTIOXIDANTS
LA English
DT Article
DE obesity; iron; fat; advanced glycation end products; testis;
   testosterone
ID HIGH-FAT DIET; METABOLIC SYNDROME; N-EPSILON-(CARBOXYMETHYL) LYSINE;
   CARBOXYMETHYL-LYSINE; SERUM TESTOSTERONE; OXIDATIVE STRESS; AGE
   RECEPTOR-1; MEN; RISK; HYPOGONADISM
AB The literature suggests a bidirectional relationship between testosterone (T) and iron, but mechanisms underlying this relationship remain unclear. We investigated effects of iron on advanced glycation end products (AGEs) in obesity-related androgen deficiency. In total, 111 men were recruited, and iron biomarkers and N(e)-(carboxymethyl)lysine (CML) were measured. In an animal study, rats were fed a 50% high-fat diet (HFD) with (0.25, 1, and 2 g ferric iron/kg diet) or without ferric citrate for 12 weeks. Obese rats supplemented with >1 g iron/kg diet had decreased testicular total T compared to HFD alone. Immunohistochemical staining showed that >1 g of ferric iron increased iron and AGE retention in testicular interstitial tissues, which is associated with increased expression of the receptor for AGEs (RAGE), tumor necrosis factor-alpha, and nitric oxide. Compared with normal weight, overweight/obese men had lower T levels and higher rates of hypogonadism (19% vs. 11.3%) and iron overload (29.8% vs.15.9%). A correlation analysis showed serum total T was positively correlated with transferrin saturation (r = 0.242, p = 0.007) and cathepsin D (r = 0.330, p = 0.001), but negatively correlated with red blood cell aggregation (r = -0.419, p<0.0001) and CML (r = -0.209, p < 0.05). In conclusion, AGEs may partially explain the underlying relationship between dysregulated iron and T deficiency.
C1 [Chen, Seu-Hwa] Taipei Med Univ, Sch Med, Dept Anat & Cell Biol, Coll Med, Taipei 110, Taiwan.
   [Yuan, Kuo-Ching] Taipei Med Univ Hosp, Dept Emergency & Crit Care Med, Taipei 110, Taiwan.
   [Lee, Yu-Chieh] Taipei Med Univ Hosp, Dept Obstet & Gynecol, Taipei 110, Taiwan.
   [Shih, Chun-Kuang; Chang, Jung-Su] Taipei Med Univ, Sch Nutr & Hlth Sci, Coll Nutr, Taipei 110, Taiwan.
   [Tseng, Sung-Hui] Taipei Med Univ Hosp, Dept Phys Med & Rehabil, Taipei 110, Taiwan.
   [Tseng, Sung-Hui] Taipei Med Univ, Sch Med, Dept Phys Med & Rehabil, Coll Med, Taipei 110, Taiwan.
   [Tinkov, Alexey A.; Skalny, Anatoly V.] RUDN Univ, Peoples Friendship Univ Russia, Dept Med Elementol, Moscow 117198, Russia.
   [Tinkov, Alexey A.; Skalny, Anatoly V.] Yaroslavl State Univ, Lab Biotechnol & Appl Bioelementol, Yaroslavl 150003, Russia.
   [Tinkov, Alexey A.; Skalny, Anatoly V.] IM Sechenov First Moscow State Med Univ, Lab Mol Dietol, Moscow 119146, Russia.
   [Chang, Jung-Su] Taipei Med Univ, Grad Inst Metab & Obes Sci, Coll Nutr, Taipei 110, Taiwan.
   [Chang, Jung-Su] Taipei Med Univ Hosp, Nutr Res Ctr, Taipei 110, Taiwan.
   [Chang, Jung-Su] CTSSO, Taipei 110, Taiwan.
C3 Taipei Medical University; Taipei Medical University Hospital; Taipei
   Medical University; Taipei Medical University Hospital; Taipei Medical
   University; Taipei Medical University; Taipei Medical University
   Hospital; Taipei Medical University; Taipei Medical University; Peoples
   Friendship University of Russia; Yaroslavl State University; Sechenov
   First Moscow State Medical University; Taipei Medical University; Taipei
   Medical University; Taipei Medical University Hospital
RP Chang, JS (corresponding author), Taipei Med Univ, Sch Nutr & Hlth Sci, Coll Nutr, Taipei 110, Taiwan.; Chang, JS (corresponding author), Taipei Med Univ, Grad Inst Metab & Obes Sci, Coll Nutr, Taipei 110, Taiwan.; Chang, JS (corresponding author), Taipei Med Univ Hosp, Nutr Res Ctr, Taipei 110, Taiwan.; Chang, JS (corresponding author), CTSSO, Taipei 110, Taiwan.
EM seuhwa@tmu.edu.tw; traumayuan@gmail.com; julyeast@gmail.com;
   ckshih@tmu.edu.tw; m003089010@tmu.edu.tw; tinkov.a.a@gmail.com;
   skalnylab@gmail.com; susanchang@tmu.edu.tw
RI Sheng, Wang/JPC-7385-2023; Tinkov, Alexey/H-5842-2016; Skalny,
   Anatoly/J-3953-2019; Shih, Chun-Kuang/R-7923-2019; YUAN,
   KUO-CHING/AAV-3637-2020
OI Chang, Jung-Su/0000-0001-8608-9349; Shih,
   Chun-Kuang/0000-0003-2545-911X; YUAN, KUO-CHING/0000-0002-0692-0559
FU Taipei Medical University Hospital [108TMU-TMUH-14]; Ministry of Science
   and Technology, Taiwan [MOST 107-2320-B-038-010-MY3]
FX This research was funded by Taipei Medical University Hospital
   (108TMU-TMUH-14) and the Ministry of Science and Technology, Taiwan
   (MOST 107-2320-B-038-010-MY3).
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NR 57
TC 10
Z9 10
U1 0
U2 16
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD MAR
PY 2020
VL 9
IS 3
AR 261
DI 10.3390/antiox9030261
PG 19
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA LB2UG
UT WOS:000524490700068
PM 32235809
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Agrawal, A
   Mabalirajan, U
AF Agrawal, Anurag
   Mabalirajan, Ulaganathan
TI Rejuvenating cellular respiration for optimizing respiratory function:
   targeting mitochondria
SO AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
LA English
DT Review
DE mitochondria; lung; chronic obstructive pulmonary disease; asthma;
   pulmonary hypertension
ID MESENCHYMAL STEM-CELLS; REDUCES ALLERGIC-ASTHMA; SMOOTH-MUSCLE; STROMAL
   CELLS; PROINFLAMMATORY ROLE; METABOLIC SYNDROME; OXIDATIVE STRESS;
   SKELETAL-MUSCLE; DYSFUNCTION; DISEASE
AB Agrawal A, Mabalirajan U. Rejuvenating cellular respiration for optimizing respiratory function: targeting mitochondria. Am J Physiol Lung Cell Mol Physiol 310: L103-L113, 2016. First published November 13, 2015; doi: 10.1152/ajplung. 00320.2015.-Altered bioenergetics with increased mitochondrial reactive oxygen species production and degradation of epithelial function are key aspects of pathogenesis in asthma and chronic obstructive pulmonary disease (COPD). This motif is not unique to obstructive airway disease, reported in related airway diseases such as bronchopulmonary dysplasia and parenchymal diseases such as pulmonary fibrosis. Similarly, mitochondrial dysfunction in vascular endothelium or skeletal muscles contributes to the development of pulmonary hypertension and systemic manifestations of lung disease. In experimental models of COPD or asthma, the use of mitochondria-targeted antioxidants, such as MitoQ, has substantially improved mitochondrial health and restored respiratory function. Modulation of noncoding RNA or protein regulators of mitochondrial biogenesis, dynamics, or degradation has been found to be effective in models of fibrosis, emphysema, asthma, and pulmonary hypertension. Transfer of healthy mitochondria to epithelial cells has been associated with remarkable therapeutic efficacy in models of acute lung injury and asthma. Together, these form a 3R model-repair, reprogramming, and replacement-for mitochondria-targeted therapies in lung disease. This review highlights the key role of mitochondrial function in lung health and disease, with a focus on asthma and COPD, and provides an overview of mitochondria-targeted strategies for rejuvenating cellular respiration and optimizing respiratory function in lung diseases.
C1 [Agrawal, Anurag; Mabalirajan, Ulaganathan] CSIR Inst Genom & Integrat Biol, Delhi, India.
C3 Council of Scientific & Industrial Research (CSIR) - India; CSIR -
   Institute of Genomics & Integrative Biology (IGIB)
RP Agrawal, A (corresponding author), Univ Delhi, CSIR IGIB, 615,Mall Rd,North Campus, Delhi 110007, India.
EM a.agrawal@igib.in
RI Agrawal, Anurag/GZL-5821-2022
OI Mabalirajan, Ulaganathan/0000-0002-2547-1023; Agrawal,
   Anurag/0000-0002-0340-5252
FU Council of Scientific and Industrial Research, India [MLP 5502];
   Swarnjayanti fellowship
FX The authors received funding support from Council of Scientific and
   Industrial Research, India, grant MLP 5502 and Swarnjayanti fellowship
   (A. Agrawal).
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NR 132
TC 62
Z9 68
U1 2
U2 51
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 1040-0605
EI 1522-1504
J9 AM J PHYSIOL-LUNG C
JI Am. J. Physiol.-Lung Cell. Mol. Physiol.
PD JAN 15
PY 2016
VL 310
IS 2
BP L103
EP L113
DI 10.1152/ajplung.00320.2015
PG 11
WC Physiology; Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology; Respiratory System
GA DC2NI
UT WOS:000369053000001
PM 26566906
OA Bronze
DA 2025-06-11
ER

PT J
AU Renes, J
   Rosenow, A
   Roumans, N
   Noben, JP
   Mariman, ECM
AF Renes, Johan
   Rosenow, Anja
   Roumans, Nadia
   Noben, Jean-Paul
   Mariman, Edwin C. M.
TI Calorie restriction-induced changes in the secretome of human
   adipocytes, comparison with resveratrol-induced secretome effects
SO BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
LA English
DT Article
DE Human adipocytes; Calorie restriction; Adipokines; Metabolic syndrome;
   2-DE LC-MS/MS
ID ADIPOSE TRIGLYCERIDE LIPASE; HORMONE-SENSITIVE LIPASE; SMALL-MOLECULE
   ACTIVATORS; WEIGHT-LOSS; IN-VITRO; MITOCHONDRIAL-FUNCTION;
   EXTRACELLULAR-MATRIX; ADIPOKINE EXPRESSION; GLUCOSE-HOMEOSTASIS;
   OXIDATIVE STRESS
AB Obesity is characterized by dysfunctional white adipose tissue (WAT) that ultimately may lead to metabolic diseases. Calorie restriction (CR) reduces the risk for age and obesity-associated complications. The impact of CR on obesity has been examined with human intervention studies, which showed alterations in circulating adipokines. However, a direct effect of CR on the human adipocyte secretome remains elusive. Therefore, the effect of a 96 h low glucose CR on the secretion profile of in vitro cultured mature human SGBS adipocytes was investigated by using proteomics technology. Low-glucose CR decreased the adipocyte triglyceride contents and resulted in an altered secretion profile. Changes in the secretome indicated an improved inflammatory phenotype. In addition, several adipocyte-secreted proteins related to insulin resistance showed a reversed expression after low-glucose CR. Furthermore, 6 novel CR-regulated adipocyte-secreted proteins were identified. Since resveratrol (RSV) mimics CR we compared results from this study with data from our previous RSV study on the SGBS adipocyte secretome. The CR and RSV adipocyte secretomes partly differed from each other, although both treatment strategies lead to secretome changes indicating a less inflammatory phenotype. Furthermore, both treatments induced SIRT1 expression and resulted in a reversed expression of detrimental adipokines associated with metabolic complications. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Renes, Johan; Rosenow, Anja; Roumans, Nadia; Mariman, Edwin C. M.] Maastricht Univ, Dept Human Biol, NUTRIM Sch Nutr Toxicol & Metab, NL-6200 MD Maastricht, Netherlands.
   [Noben, Jean-Paul] Hasselt Univ, Biomed Res Inst, Diepenbeek, Belgium.
   [Noben, Jean-Paul] Transnat Univ Limburg, Sch Life Sci, Diepenbeek, Belgium.
C3 Maastricht University; Maastricht University Medical Centre (MUMC);
   Hasselt University; Hasselt University
RP Renes, J (corresponding author), Maastricht Univ, Dept Human Biol, POB 616, NL-6200 MD Maastricht, Netherlands.
EM j.renes@maastrichtuniversity.nl
RI Noben, Jean-Paul/E-8066-2011
OI Roumans, Nadia/0000-0003-4789-1050; Noben, Jean-Paul/0000-0003-3368-5686
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NR 73
TC 19
Z9 21
U1 0
U2 19
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1570-9639
EI 1878-1454
J9 BBA-PROTEINS PROTEOM
JI BBA-Proteins Proteomics
PD SEP
PY 2014
VL 1844
IS 9
BP 1511
EP 1522
DI 10.1016/j.bbapap.2014.04.023
PG 12
WC Biochemistry & Molecular Biology; Biophysics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics
GA AN1JV
UT WOS:000340339500010
PM 24802182
DA 2025-06-11
ER

PT J
AU Ishida, S
   Koto, T
   Nagai, N
   Oike, Y
AF Ishida, Susumu
   Koto, Takashi
   Nagai, Norihiro
   Oike, Yuichi
TI Calcium Channel Blocker Nilvadipine, but Not Diltiazem, Inhibits Ocular
   Inflammation in Endotoxin-Induced Uveitis
SO JAPANESE JOURNAL OF OPHTHALMOLOGY
LA English
DT Article
DE calcium channel blocker; endotoxin-induced uveitis; intercellular
   adhesion
ID CHOROIDAL NEOVASCULARIZATION; OXIDATIVE STRESS; IN-VIVO; KAPPA-B;
   GENE-TRANSCRIPTION; INSULIN-RESISTANCE; RADICAL PRODUCTION; METABOLIC
   SYNDROME; ENDOTHELIAL-CELLS; ATHEROSCLEROSIS
AB Purpose: Calcium channel blockers (CCBs), widely used for hypertensive patients, have recently been shown to inhibit atherosclerosis by their antioxidative action. The aim of the present study was to examine whether the CCBs nilvadipine and diltiazem reduce ocular inflammation in endotoxin-induced uveitis (EIU).
   Methods: EIU was induced in male C57/B6 mice with a single intraperitoneal injection of lipopolysaccharide (LPS). The animals received intraperitoneal injections of either nilvadipine, diltiazem, or vehicle for 5 days before the LPS application. Twenty-four hours after EIU induction, adherent leukocytes to the retinal vasculature were counted with a concanavalin A lectin perfusion-labeling technique. The protein concentration in the aqueous humor was measured to assess blood-ocular barrier breakdown. Retinal levels of intercellular adhesion molecule (ICAM)-1 and monocyte chemotactic protein (MCP)-1 were analyzed by enzyme-linked immunosorbent assay. LPS-stimulated generation of superoxide in murine microvascular endothelial cells was examined with a nitroblue tetrazolium assay.
   Results: Compared to vehicle treatment, application of nilvadipine, but not diltiazem, led to significant suppression of EIU-associated retinal leukocyte adhesion, together with anterior-chamber protein leakage, retinal expression of ICAM-1 and MCP-1, and LPS-induced superoxide generation in vitro.
   Conclusions: The CCB nilvadipine exercises an inhibitory effect on the pathogenesis of ocular inflammation through the suppression of inflammation-related molecules. Jpn J Ophthalmol 2010;54:594-601 (C) Japanese Ophthalmological Society 2010
C1 [Ishida, Susumu] Hokkaido Univ, Grad Sch Med, Dept Ophthalmol, Kita Ku, Sapporo, Hokkaido 0608638, Japan.
   [Ishida, Susumu; Koto, Takashi; Nagai, Norihiro; Oike, Yuichi] Keio Univ, Sch Med, Lab Retinal Cell Biol, Tokyo, Japan.
   [Koto, Takashi; Nagai, Norihiro] Keio Univ, Sch Med, Dept Ophthalmol, Tokyo, Japan.
   [Oike, Yuichi] Kumamoto Univ, Grad Sch Med Sci, Dept Mol Genet, Kumamoto, Japan.
C3 Hokkaido University; Keio University; Keio University; Kumamoto
   University
RP Ishida, S (corresponding author), Hokkaido Univ, Grad Sch Med, Dept Ophthalmol, Kita Ku, N-15,W-7, Sapporo, Hokkaido 0608638, Japan.
EM ishidasu@med.hokudai.ac.jp
RI ISHIDA, SUSUMU/D-7067-2012
FU Japanese Ministry of Education, Culture, Sports, Science and Technology
   [17791255]; Grants-in-Aid for Scientific Research [17791255, 21592243]
   Funding Source: KAKEN
FX The authors thank Drs. Junichi Fukuhara, Atsuhiro Kanda and Kousuke Noda
   (Hokkaido University, Sapporo, Japan) for technical assistance and Drs.
   Yoko Ozawa, Kazuo Tsubota (Keio University, Tokyo, Japan) and Shigeaki
   Ohno (Hokkaido University, Sapporo, Japan) for their expert advice. This
   research was funded by a Grant-in-Aid for Scientific Research from the
   Japanese Ministry of Education, Culture, Sports, Science and Technology
   (No. 17791255 to N.N.)
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NR 68
TC 6
Z9 6
U1 0
U2 0
PU SPRINGER TOKYO
PI TOKYO
PA 1-11-11 KUDAN-KITA, CHIYODA-KU, TOKYO, 102-0073, JAPAN
SN 0021-5155
J9 JPN J OPHTHALMOL
JI Jpn. J. Ophthalmol.
PD NOV
PY 2010
VL 54
IS 6
BP 594
EP 601
DI 10.1007/s10384-010-0862-5
PG 8
WC Ophthalmology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Ophthalmology
GA 709VK
UT WOS:000286469300012
PM 21191722
DA 2025-06-11
ER

PT J
AU Wang, J
   Chang, T
AF Wang, J.
   Chang, T.
TI Methylglyoxal Content in Drinking Coffee as a Cytotoxic Factor
SO JOURNAL OF FOOD SCIENCE
LA English
DT Article
DE apoptosis; coffee; methylglyoxal; scavenger
ID SMOOTH-MUSCLE-CELLS; TYPE-2 DIABETES-MELLITUS; OXIDATIVE STRESS;
   PEROXYNITRITE PRODUCTION; HYPERTENSION; GLYCATION; POLYPHENOLS;
   INHIBITION; APOPTOSIS; BEVERAGES
AB A causal relationship between metabolic syndrome and methylglyoxal (MG) has been suggested. Consumption of coffee and other types of beverages has been known to produce MG, thus resulting in both nutritional and health concerns. The purpose of this study was to determine the ideal combination of coffee, cream, and sugar in order to minimize MG consumption. Four types of black coffee were tested: espresso, bold, mild, and a decaffeinated mild roast. Sugar and/or cream were added to the coffee samples to test whether MG levels were altered. Using high-performance liquid chromatography, the concentration of MG in various coffee samples was determined. The espresso coffee sample was found to contain the highest level of MG at 230.9 mu M. The bold coffee roast had the 2nd highest amount of MG, followed by the mild and decaffeinated varieties. Adding cream to bold coffee significantly reduced its MG level in comparison to the coffee sample without cream. On the other hand, the addition of sugar to the bold coffee did not further increase the MG level in the samples. The cellular damaging effect of MG was shown as there were decreased numbers of cultured HEK-293 cells after 24 h of MG treatment (100 and 300 mu M), which is consistent with an increased cell apoptosis induced by MG treatment (100 and 300 mu M). Due to the overconsumption of exogenous MG, drinking an excess of any type of coffee poses health risks.
C1 [Chang, T.] Univ Saskatchewan, Dept Pharmacol, Saskatoon, SK S7N 5E5, Canada.
   [Wang, J.] Walter Murray Coll Inst, Saskatoon, SK S7J 2E7, Canada.
C3 University of Saskatchewan
RP Chang, T (corresponding author), Univ Saskatchewan, Dept Pharmacol, Saskatoon, SK S7N 5E5, Canada.
EM tuc677@mail.usask.ca
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NR 33
TC 40
Z9 43
U1 2
U2 20
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-1147
EI 1750-3841
J9 J FOOD SCI
JI J. Food Sci.
PD AUG
PY 2010
VL 75
IS 6
BP H167
EP H171
DI 10.1111/j.1750-3841.2010.01658.x
PG 5
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA 644JN
UT WOS:000281372000057
PM 20722928
DA 2025-06-11
ER

PT J
AU Maedler, K
   Dharmadhikari, G
   Schumann, DM
   Storling, J
AF Maedler, Kathrin
   Dharmadhikari, Gitanjali
   Schumann, Desiree M.
   Storling, Joachim
TI Interleukin-1 beta targeted therapy for type 2 diabetes
SO EXPERT OPINION ON BIOLOGICAL THERAPY
LA English
DT Review
DE diabetes; IL-1Ra; IL-1 beta; beta-cell
ID BETA-CELL DEATH; IL-1 RECEPTOR ANTAGONIST; ENDOPLASMIC-RETICULUM STRESS;
   PANCREATIC-ISLET TRANSPLANTATION; CYTOKINE-INDUCED APOPTOSIS; ADENOVIRAL
   GENE-TRANSFER; JUN NH2-TERMINAL KINASE; TUMOR-NECROSIS-FACTOR;
   DIET-INDUCED OBESITY; ISOLATED RAT ISLETS
AB Since having been cloned in 1984, IL-1 beta has been the subject of over 22,000 citations in Pubmed, among them over 800 reviews. This is because of its numerous effects. IL-1 beta is a regulator of the body's inflammatory response and is produced after infection, injury, and antigenic challenge. It plays a role in various diseases, including autoimmune diseases such as rheumatoid arthritis, inflammatory bowel diseases and type 1 diabetes, as well as in diseases associated with metabolic syndrome such as atherosclerosis, chronic heart failure and type 2 diabetes. Macrophage are the primary source of IL-1, but epidermal, epithelial, lymphoid and vascular tissues also synthesize IL-1. IL-1 beta production and secretion have also been reported from pancreatic islets. Insulin-producing beta-cells within pancreatic islets are specifically prone to IL-beta-induced destruction and loss of function. Macrophage-derived IL-1 beta production in insulin-sensitive organs, leads to progression of inflammation and induction of insulin resistance in obesity. We summarize the mechanisms involved in inflammation and specifically the IL-1 beta signals that lead to the progression of insulin resistance and diabetes. We highlight recent clinical studies and experiments in animals and isolated islets using IL-1 beta as a potential target for the therapy of type 2 diabetes.
C1 [Maedler, Kathrin; Dharmadhikari, Gitanjali] Univ Bremen, Ctr Biomol Interact Bremen, Islet Biol Lab, D-28359 Bremen, Germany.
   [Schumann, Desiree M.] Boehringer Ingelheim GmbH & Co KG, Cardiometab Dis Res, Biberach, Germany.
   [Storling, Joachim] Hagedorn Res Inst, Gentofte, Denmark.
C3 University of Bremen; Boehringer Ingelheim; Novo Nordisk; Hagedorn
   Research Institute
RP Maedler, K (corresponding author), Univ Bremen, Ctr Biomol Interact, D-28359 Bremen, Germany.
EM kmaedler@uni-bremen.de
RI Maedler, Kathrin/ABE-3022-2021
OI Schumann, Desiree/0000-0002-1172-7438; Storling,
   Joachim/0000-0002-7529-4264; Maedler, Kathrin/0000-0002-7436-1197
FU German Research Foundation [MA4172/1-1]; Juvenile Diabetes Research
   Foundation [UDRF 26-2008-861]; European Foundation
FX This work was supported by the German Research Foundation (DFG, Emmy
   Noether Programm, MA4172/1-1), the Juvenile Diabetes Research Foundation
   UDRF 26-2008-861) and the European Foundation for the Study of Diabetes
   (EFSD)/Merck Sharp & Dohme (MSD) European Studies on Beta Cell Function
   and Survival. The authors thank the members of the Islet Biology
   laboratory in Bremen for critical discussion.
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NR 147
TC 105
Z9 121
U1 1
U2 15
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1471-2598
EI 1744-7682
J9 EXPERT OPIN BIOL TH
JI Expert Opin. Biol. Ther.
PD SEP
PY 2009
VL 9
IS 9
BP 1177
EP 1188
DI 10.1517/14712590903136688
PG 12
WC Biotechnology & Applied Microbiology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Research & Experimental Medicine
GA 489CV
UT WOS:000269398200006
PM 19604125
DA 2025-06-11
ER

PT J
AU Largo, R
   Mediero, A
   Villa-Gomez, C
   Bermejo-Alvarez, I
   Herrero-Beaumont, G
AF Largo, R.
   Mediero, A.
   Villa-Gomez, C.
   Bermejo-Alvarez, I.
   Herrero-Beaumont, G.
TI Aberrant anabolism hinders constructive metabolism of chondrocytes by
   pharmacotherapy in osteoarthritis
SO BONE & JOINT RESEARCH
LA English
DT Article
ID NONSTEROIDAL ANTIINFLAMMATORY DRUGS; LOW-GRADE INFLAMMATION;
   ARTICULAR-CARTILAGE; SIGNALING PATHWAY; KNEE; PATHOGENESIS; ACTIVATION;
   DIFFERENTIATION; CHONDROGENESIS; DEGENERATION
AB Osteoarthritis (OA) is a highly prevalent and disabling disease with an unmet therapeutic need. The characteristic cartilage loss and alteration of other joint structures result from a complex interaction of multiple risk factors, with mechanical overload consistently playing a central role. This overload generates an inflammatory response in the cartilage due to the activation of the innate immune response in chondrocytes, which occurs through various cellular mechanisms. Moreover, risk factors associated with obesity, being overweight, and metabolic syndrome enhance the inflammatory response both locally and systemically. OA chondrocytes, the only cells present in articular cartilage, are therefore inflamed and initiate an anabolic process in an attempt to repair the damaged tissue, which ultimately results in an aberrant and dysfunctional process. Under these circumstances, where the cartilage continues to be subjected to chronic mechanical stress, proposing a treatment that stimulates the chondrocytes' anabolic response to restore tissue structure does not appear to be a therapeutic target with a high likelihood of success. In fact, anabolic drugs proposed for the treatment of OA have yet to demonstrate efficacy. By contrast, multiple therapeutic strategies focused on pharmacologically managing the inflammatory component, both at the joint and systemic levels, have shown promise. Therefore, prioritizing the control of chronic innate pro-inflammatory pathways presents the most viable and promising therapeutic strategy for the effective management of OA. As research continues, this approach may offer the best opportunity to alleviate the burden of this incapacitating disease.
C1 [Largo, R.; Mediero, A.; Villa-Gomez, C.; Bermejo-Alvarez, I.; Herrero-Beaumont, G.] IIS Fdn Jimenez Diaz UAM, Serv Rheumatol, Joint & Bone Res Unit, Madrid, Spain.
   IIS Fdn Jimenez Diaz UAM, Madrid, Spain.
C3 Fundacion Jimenez Diaz; Fundacion Jimenez Diaz
RP Mediero, A (corresponding author), IIS Fdn Jimenez Diaz UAM, Serv Rheumatol, Joint & Bone Res Unit, Madrid, Spain.
EM aranzazu.mediero@quironsalud.es
RI Largo, Raquel/B-2949-2009
OI Largo, Raquel/0000-0001-6525-2944
FU Instituto de Salud Carlos III (ISCIII) [PI20/00349, PI22/00352,
   PI22/00347, RICOR-RD21/0002/0025]; Fondo Europeo de Desarrollo Regional
   (FEDER)
FX Funding statement The author (s) disclose receipt of the following
   financial or material support for the research, authorship, and/or
   publication of this article: this work was supported by grants from the
   Instituto de Salud Carlos III (ISCIII, PI20/00349; PI22/00352,
   PI22/00347 and RICOR-RD21/0002/0025) , co-funded by Fondo Europeo de
   Desarrollo Regional (FEDER) .
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NR 95
TC 0
Z9 0
U1 2
U2 2
PU BRITISH EDITORIAL SOC BONE & JOINT SURGERY
PI LONDON
PA 22 BUCKINGHAM STREET, LONDON WC2N 6ET, ENGLAND
SN 2046-3758
J9 BONE JOINT RES
JI Bone Jt. Res.
PD MAR
PY 2025
VL 14
IS 3
BP 199
EP 207
DI 10.1302/2046-3758.143.BJR-2024-0241.R1
PG 9
WC Cell & Tissue Engineering; Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Orthopedics
GA 0KZ2B
UT WOS:001449859400004
PM 40042132
OA gold, Green Accepted
DA 2025-06-11
ER

PT J
AU Zhang, YF
   Lin, YJ
   Wu, KY
   Jiang, M
   Li, LZ
   Liu, Y
AF Zhang, Yongfeng
   Lin, Yingjie
   Wu, Keyi
   Jiang, Ming
   Li, Lanzhou
   Liu, Yang
TI Pleurotus abieticola Polysaccharide Alleviates Hyperlipidemia
   Symptoms via Inhibition of Nuclear Factor-κB/Signal Transducer and
   Activator of Transcription 3-Mediated Inflammatory Responses
SO NUTRIENTS
LA English
DT Article
DE Pleurotus abieticola; hyperlipidemia; inflammation; NF-kappa B/STAT3
   signaling pathway
ID OXIDATIVE STRESS; OBESITY; FAT; ALDEHYDES; MICE
AB Hyperlipidemia (HLP) is a metabolic syndrome induced by obesity, which has been widely recognized as a significant threat to human health. Pleurotus abieticola, an edible lignin-degrading fungus, remains relatively understudied in terms of its bioactivity and medicinal properties. In this study, the lipid-lowering effect of Pleurotus abieticola polysaccharide (PAPS1) was systematically explored in high-fat diet (HFD)-induced HLP mice. The findings demonstrated that the administration of PAPS1 significantly inhibited bodyweight gain, ameliorated blood glucose and lipid levels, reduced fat accumulation, and mitigated hepatic injury in HLP mice. In addition, PAPS1 demonstrated the capability to increase the levels of three distinct fecal metabolites while simultaneously reducing the levels of eight other fecal metabolites in HLP mice. According to biological detection, PAPS1 reduced the hepatic level of reactive oxygen species (ROS) and pro-inflammatory factors, such as tumor necrosis factor (TNF)-alpha and interleukin (IL)-1 beta, -6, -17A, -22, and -23, and increased the expression of anti-inflammatory factor IL-10. Combined with proteomics, Western blot and immunohistochemistry analysis showed that PAPS1 exerted suppressive effects on inflammation and oxidative damage by inhibiting the nuclear factor-kappa B (NF-kappa B)/signal transducer and activator of transcription 3 (STAT3) signaling pathway in HLP mice. These findings offer evidence supporting the effectiveness of PAPS1 as a therapeutic agent in reducing lipid levels through its targeting of chronic inflammation.
C1 [Zhang, Yongfeng; Lin, Yingjie; Wu, Keyi; Li, Lanzhou; Liu, Yang] Jilin Agr Univ, Engn Res Ctr, Chinese Minist Educ Edible & Med Fungi, Changchun 130118, Peoples R China.
   [Jiang, Ming] Mudanjiang Normal Univ, Coll Life Sci & Technol, Mudanjiang 157011, Peoples R China.
C3 Jilin Agricultural University; Mudanjiang Normal University
RP Li, LZ; Liu, Y (corresponding author), Jilin Agr Univ, Engn Res Ctr, Chinese Minist Educ Edible & Med Fungi, Changchun 130118, Peoples R China.
EM zhangyongfeng@jlau.edu.cn; linyingjie@uor.edu.cn;
   wukeyi@mails.jlau.edu.cn; jiangming@mdjnu.edu.cn; lilanzhou@jlau.edu.cn;
   y_liu10@jlau.edu.cn
RI Li, zhuangzhuang/JAD-1371-2023; Zhang, Yongfeng/HMW-1599-2023
FU National Natural Science Foundation of China
FX No Statement Available
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NR 54
TC 4
Z9 4
U1 8
U2 28
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD DEC
PY 2023
VL 15
IS 23
AR 4904
DI 10.3390/nu15234904
PG 17
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA AN1A9
UT WOS:001119041600001
PM 38068762
OA gold
DA 2025-06-11
ER

PT J
AU Pratt-Phillips, S
   Munjizun, A
AF Pratt-Phillips, Shannon
   Munjizun, Ahmad
TI Impacts of Adiposity on Exercise Performance in Horses
SO ANIMALS
LA English
DT Review
DE equine; obesity; exercise; performance
ID BODY CONDITION SCORE; RISK-FACTORS; WEIGHT-LOSS; INFLAMMATORY CYTOKINES;
   REPRODUCTIVE ACTIVITY; INSULIN SENSITIVITY; RIDING HORSES; OBESITY;
   LAMINITIS; FAT
AB Simple Summary Increased incidence of obesity in our equine population has clear negative impacts on equine health, such as increasing the risk of equine metabolic syndrome and laminitis. Excessive adipose tissue likely also has negative impacts on exercise performance, due to a combined inflammatory response and the effects of excessive weight carriage on work effort and limb health. This review explores research conducted in these areas. There is ample research describing the increased risk of health concerns associated with equine obesity, including insulin dysregulation and laminitis. For athletes, the negative effect of weight carriage is well documented in racing thoroughbreds (i.e., handicapping with weight) and rider weight has been shown to impact the workload of ridden horses and to some degree their gait and movement. In many groups of competitive and athletic horses and ponies, obesity is still relatively common. Therefore, these animals not only are at risk of metabolic disease, but also must perform at a higher workload due to the weight of their adipose tissue. Excess body weight has been documented to affect gait quality, cause heat stress and is expected to hasten the incidence of arthritis development. Meanwhile, many equine event judges appear to favor the look of adiposity in competitive animals. This potentially rewards horses and ponies that are at higher risk of disease and reinforces the owner's decisions to keep their animals fat. This is a welfare concern for these animals and is of grave concern for the equine industry.
C1 [Pratt-Phillips, Shannon; Munjizun, Ahmad] North Carolina State Univ, Dept Anim Sci, Raleigh, NC 27695 USA.
C3 North Carolina State University
RP Pratt-Phillips, S (corresponding author), North Carolina State Univ, Dept Anim Sci, Raleigh, NC 27695 USA.
EM sepratt2@ncsu.edu
OI Pratt-Phillips, Shannon/0000-0003-4130-6957
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NR 124
TC 5
Z9 5
U1 1
U2 18
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 2076-2615
J9 ANIMALS-BASEL
JI Animals
PD FEB
PY 2023
VL 13
IS 4
AR 666
DI 10.3390/ani13040666
PG 14
WC Agriculture, Dairy & Animal Science; Veterinary Sciences; Zoology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture; Veterinary Sciences; Zoology
GA 9F9TU
UT WOS:000937806100001
PM 36830453
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Arnaboldi, L
   Corsini, A
   Bellosta, S
AF Arnaboldi, Lorenzo
   Corsini, Alberto
   Bellosta, Stefano
TI Artichoke and bergamot extracts: a new opportunity for the management of
   dyslipidemia and related risk factors
SO MINERVA MEDICA
LA English
DT Review
DE Functional food; Hyperlipidemias; Polyphenols
ID CYNARA-SCOLYMUS L.; NITRIC-OXIDE SYNTHASE; CITRUS-BERGAMIA; OXIDATIVE
   STRESS; CHOLESTEROL-BIOSYNTHESIS; LOWERING NUTRACEUTICALS;
   LDL-CHOLESTEROL; PROTEIN-KINASE; LEAF TINCTURE; FLAVONOIDS
AB The relationship between low LDL-C (cholesterol associated with low-density lipoprotein) and a lower relative risk of developing cardiovascular disease (CVD) has been widely demonstrated. Although from a pharmacological point of view, starins, ezetimibe and PCSK inhibitors, alone or in combination are the front and center of the therapeutic approaches for reducing LDL-C and its CV consequences, in recent years nutraceuticals and functional foods have increasingly been considered as a valid support in the reduction of LDL-C, especially in patients with mild/moderate hvperlipidemia - therefore not requiring pharmacological treatment - or in patients intolerant to statins or other drugs. An approach also shared by the European Atherosclerosis Society (EAS). Of the various active ingredients with hypolipidemic properties, we include the artichoke (Cynara cardunculus, Cynara scolyrnus) and the bergamot (Citrus betgamia) which, thanks essentially to the significant presence of polyphenols in their extracts, can exert this action associated with a number of other complementary inflammation and oxidation benefits. In light of these evidence, this review aimed to describe the effects of artichoke and bergamot in modifying the lipid and inflammatory parameters described in in vitro, in vivo and clinical studies. The available data support the use of standardized compositions of artichoke and bergamot extracts, alone or in combination, in the treatment of mild to moderate dyslipidemia, in patients suffering from metabolic syndrome, hepatic steatosis, or intolerant to common hypolipidemic treatments.
C1 [Arnaboldi, Lorenzo; Corsini, Alberto; Bellosta, Stefano] Univ Milan, Dept Pharmacol & Biomol Sci, Via Balzaretti 9, I-20133 Milan, Italy.
C3 University of Milan
RP Bellosta, S (corresponding author), Univ Milan, Dept Pharmacol & Biomol Sci, Via Balzaretti 9, I-20133 Milan, Italy.
EM stefano.bellosta@unimi.it
RI Bellosta, Stefano/B-4473-2010
OI Arnaboldi, Lorenzo/0000-0002-4017-7631
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NR 114
TC 5
Z9 5
U1 1
U2 15
PU EDIZIONI MINERVA MEDICA
PI TURIN
PA CORSO BRAMANTE 83-85 INT JOURNALS DEPT., 10126 TURIN, ITALY
SN 0026-4806
EI 1827-1669
J9 MINERVA MED
JI Minerva Med.
PD FEB
PY 2022
VL 113
IS 1
BP 141
EP 157
DI 10.23736/S0026-4806.21.07950-7
PG 17
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA ZX6OC
UT WOS:000772013000014
PM 35313442
DA 2025-06-11
ER

PT J
AU Kheirouri, S
   Alizadeh, M
AF Kheirouri, Sorayya
   Alizadeh, Mohammad
TI MIND diet and cognitive performance in older adults: a systematic review
SO CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
LA English
DT Review
DE Brain health; cognitive performance; MIND diet
ID VIRGIN OLIVE OIL; OXIDATIVE STRESS; AMYLOID-BETA; MEDITERRANEAN DIET;
   ALZHEIMERS-DISEASE; METABOLIC SYNDROME; PHYSICAL-ACTIVITY; FISH INTAKE;
   DASH DIET; DECLINE
AB Cognitive decline is a rapidly increasing public health concern. A healthy diet has potential in preserving brain and maintaining cognitive health. This systematic review was designed to evaluate the relationship between Mediterranean-DASH diet intervention for neurodegenerative delay (MIND) diet and cognitive functioning in older adults. PubMed, SCOPUS, Embase, Cochrane Library, and Google Scholar databases were searched to extract original studies on humans published until July 2020, without date restrictions. Articles that evaluated the association between MIND diet and cognitive performance in older adults were included. Duplicated and irrelevant studies were screened out and data were obtained through critical analysis. Quality of the articles and risk of bias was assessed by Newcastle-Ottawa and Cochrane Collaboration's quality assessment tools. Of the 135 studies retrieved, 13 articles (9 cohort, 3 cross-sectional, and 1 RCT studies) were included in the final review. All of the included studies indicated that adherence to the MIND diet was positively associated with specific domains, but not all, of cognition and global cognitive function (78% of the studies) in older adults. MIND diet was superior to other plant-rich diets including Mediterranean, Dietary Approaches to Stop Hypertension, Pro-Vegetarian and Baltic Sea diets, for improving cognition. Adherence to the MIND diet may possibly be associated with an improved cognitive function in older adults. MIND diet may be superior to other plant-rich diets for improving cognition.
C1 [Kheirouri, Sorayya] Tabriz Univ Med Sci, Fac Nutr, Dept Nutr, Attar Nishabouri St,POB 14711, Tabriz 5166614711, Iran.
   [Alizadeh, Mohammad] Tabriz Univ Med Sci, Nutr Res Ctr, Tabriz, Iran.
C3 Tabriz University of Medical Science; Tabriz University of Medical
   Science
RP Kheirouri, S (corresponding author), Tabriz Univ Med Sci, Fac Nutr, Dept Nutr, Attar Nishabouri St,POB 14711, Tabriz 5166614711, Iran.; Alizadeh, M (corresponding author), Tabriz Univ Med Sci, Dept Nutr, Fac Nutr & Food Sci, Attar Nishabouri St,POB 14711, Tabriz 5166614711, Iran.
EM Kheirouris@tbzmed.ac.ir; mdalizadeh@tbzmed.ac.ir
RI Alizadeh, Mohammad/M-4703-2017
FU Tabriz University of Medical Sciences
FX This study was financially supported by Tabriz University of Medical
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NR 95
TC 82
Z9 84
U1 12
U2 80
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1040-8398
EI 1549-7852
J9 CRIT REV FOOD SCI
JI Crit. Rev. Food Sci. Nutr.
PD OCT 17
PY 2022
VL 62
IS 29
BP 8059
EP 8077
DI 10.1080/10408398.2021.1925220
EA MAY 2021
PG 19
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA 5D4SN
UT WOS:000650484800001
PM 33989093
DA 2025-06-11
ER

PT J
AU Morán-Costoya, A
   Proenza, AM
   Gianotti, M
   Lladó, I
   Valle, A
AF Moran-Costoya, Andrea
   Proenza, Ana M.
   Gianotti, Magdalena
   Llado, Isabel
   Valle, Adamo
TI Sex Differences in Nonalcoholic Fatty Liver Disease: Estrogen Influence
   on the Liver-Adipose Tissue Crosstalk
SO ANTIOXIDANTS & REDOX SIGNALING
LA English
DT Article
DE NAFLD; estrogen; steatosis; NASH; menopause; hormone replacement therapy
ID PROLIFERATOR-ACTIVATED RECEPTOR; RETINOL-BINDING-PROTEIN;
   HORMONE-REPLACEMENT THERAPY; N-TERMINAL KINASE; BODY-WEIGHT GAIN;
   INSULIN-RESISTANCE; POSTMENOPAUSAL WOMEN; PLASMA ADIPONECTIN; METABOLIC
   SYNDROME; HEPATIC STEATOSIS
AB Significance: Nonalcoholic fatty liver disease (NAFLD) is a hepatic and systemic disorder with a complex multifactorial pathogenesis. Owing to the rising incidence of obesity and diabetes mellitus, the prevalence of NAFLD and its impact on global health care are expected to increase in the future. Differences in NAFLD exist between males and females, and among females depending on their reproductive status. Clinical and preclinical data show that females in the fertile age are more protected against NAFLD, and studies in postmenopausal women and ovariectomized animal models support a protective role for estrogens.
   Recent Advances: An efficient crosstalk between the liver and adipose tissue is necessary to regulate lipid and glucose metabolism, protecting the liver from steatosis and insulin resistance contributing to NALFD. New advances in the knowledge of sexual dimorphism in liver and adipose tissue are providing interesting clues about the sex differences in NAFLD pathogenesis that could inspire new therapeutic strategies.
   Critical Issues: Sex hormones influence key master regulators of lipid metabolism and oxidative stress in liver and adipose tissue. All these sex-biased metabolic adjustments shape the crosstalk between liver and adipose tissue, contributing to the higher protection of females to NAFLD.
   Future Directions: The development of novel drugs based on the protective action of estrogens, but without its feminizing or undesired side effects, might provide new therapeutic strategies for the management of NAFLD.
C1 [Moran-Costoya, Andrea; Proenza, Ana M.; Gianotti, Magdalena; Llado, Isabel; Valle, Adamo] Univ Balearic Isl, Dept Fundamental Biol & Hlth Sci, Res Inst Hlth Sci IUNICS, Energy Metab & Nutr Grp, Palma De Mallorca, Spain.
   [Moran-Costoya, Andrea; Proenza, Ana M.; Gianotti, Magdalena; Llado, Isabel; Valle, Adamo] Hlth Res Inst Balearic Isl IdISBa, Palma De Mallorca, Spain.
   [Proenza, Ana M.; Gianotti, Magdalena; Llado, Isabel; Valle, Adamo] Carlos III Hlth Inst, Ctr Biomed Res Pathophysiol Obes & Nutr Network, Madrid, Spain.
C3 Universitat de les Illes Balears; IUNICS; Institut Investigacio
   Sanitaria Illes Balears (IdISBa)
RP Valle, A (corresponding author), Univ Balearic Isl, Dept Fundamental Biol & Hlth Sci, Res Inst Hlth Sci IUNICS, Energy Metab & Nutr Grp, Palma De Mallorca, Spain.; Valle, A (corresponding author), Hlth Res Inst Balearic Isl IdISBa, Palma De Mallorca, Spain.; Valle, A (corresponding author), Carlos III Hlth Inst, Ctr Biomed Res Pathophysiol Obes & Nutr Network, Madrid, Spain.
EM adamo.valle@uib.es
RI Lladó, Isabel/I-1540-2015; Morán-Costoya, Andrea/HGC-4729-2022; Proenza,
   Ana Maria/L-3383-2014; Gianotti, Magdalena/H-7725-2015; Valle,
   Adamo/H-7042-2017
OI Proenza, Ana Maria/0000-0001-8153-5442; Moran Costoya,
   Andrea/0000-0003-1219-6832; Gianotti, Magdalena/0000-0002-5225-9079;
   Valle, Adamo/0000-0001-7217-2811
FU FEDER/Ministerio de Ciencia, Innovacion y Universidades, Agencia Estatal
   de Investigacion of the Spanish Government [SAF2016-80384R]
FX This work was supported by FEDER/Ministerio de Ciencia, Innovacion y
   Universidades, Agencia Estatal de Investigacion (SAF2016-80384R) of the
   Spanish Government.
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NR 200
TC 34
Z9 35
U1 2
U2 21
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1523-0864
EI 1557-7716
J9 ANTIOXID REDOX SIGN
JI Antioxid. Redox Signal.
PD SEP 20
PY 2021
VL 35
IS 9
BP 753
EP 774
DI 10.1089/ars.2021.0044
EA MAY 2021
PG 22
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA UM5JY
UT WOS:000646810200001
PM 33736456
DA 2025-06-11
ER

PT J
AU Paik, JS
   Yang, SW
   Cho, WK
   Kim, HS
   Na, KS
   Han, K
AF Paik, Ji-Sun
   Yang, Suk-Woo
   Cho, Won-Kyung
   Kim, Hyun-Seung
   Na, Kyung-Sun
   Han, Kyungdo
TI Association between Blepharoptosis and Pterygium in Korea: A
   Population-Based Study during 2010-2012
SO SEMINARS IN OPHTHALMOLOGY
LA English
DT Article
DE Pterygium; blepharoptosis; population-based; gender difference;
   epidemiology
ID RISK-FACTORS; RACIAL-DIFFERENCES; OXIDATIVE DAMAGE; PREVALENCE;
   CONJUNCTIVA; ADULTS
AB Purpose: To investigate possible correlations between blepharoptosis and pterygium in a nationally representative sample of the Korean population. Methods: This population-based, cross-sectional study was comprised of 3,685 males and 4,792 females (>= 19 years of age) participating in the fifth annual Korea National Health and Nutrition Examination Survey (KNHANES) from 2010 to 2012. The enrolled subjects underwent interviews, clinical examinations, and laboratory tests. Statistical tests were used to compare the prevalence of blepharoptosis, according to pterygium subtypes or pterygium existence. Multiple logistic regression analyses were also used to find the associations of blepharoptosis with pterygium. Results: Pterygium was present in 10.3% of males and 9.8% of females. The odds ratios (ORs) of pterygium in Korean males significantly decreased as the severity of blepharoptosis increased (p for trend = 0.0252). Using three models in multivariate analyses, males with blepharoptosis had an OR (95% confidence interval, (CI)) of 0.643 (0.435 similar to 0.951) for pterygium compared with males with no blepharoptosis, after adjusting for age, body mass index, smoking status, alcohol consumption, physical activity, serum vitamin D levels, diabetes mellitus, metabolic syndrome, high blood pressure, and stress intolerance. There was no significant association between blepharoptosis and females. Conclusions: The association between blepharoptosis and pterygium in the Korean population showed a gender difference. Epidemiologic evidence only showed a negative correlation between blepharoptosis and pterygium in Korean males. Further studies are needed, therefore, to examine the sex difference in the pathogenesis of pterygium.
C1 [Paik, Ji-Sun; Yang, Suk-Woo] Catholic Univ Korea, Seoul St Marys Hosp, Coll Med, Dept Ophthalmol, Seoul, South Korea.
   [Cho, Won-Kyung] Catholic Univ Korea, Daejeon St Marys Hosp, Coll Med, Dept Ophthalmol, Daejeon, South Korea.
   [Kim, Hyun-Seung; Na, Kyung-Sun] Catholic Univ Korea, Yeouido St Marys Hosp, Coll Med, Dept Ophthalmol, 63 Ro 10, Seoul, South Korea.
   [Han, Kyungdo] Catholic Univ Korea, Dept Biostat, Seoul, South Korea.
C3 Seoul St. Mary's Hospital; Catholic University of Korea; Catholic
   University of Korea; Catholic University of Korea; Catholic University
   of Korea
RP Na, KS (corresponding author), Catholic Univ Korea, Yeouido St Marys Hosp, Coll Med, Dept Ophthalmol, 63 Ro 10, Seoul, South Korea.
EM drna@catholic.ac.kr
RI Kim, Hyun-Jong/X-3662-2019; Han, Kyungdo/JKH-7628-2023
FU Basic Science Research Program through the National Research Foundation
   of Korea (NRF) - Ministry of Education [2016R1D1A1B03930886]
FX This researh was supported by Basic Science Research Program through the
   National Research Foundation of Korea (NRF) funded by Ministry of
   Education (2016R1D1A1B03930886).
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NR 29
TC 1
Z9 1
U1 0
U2 1
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 0882-0538
EI 1744-5205
J9 SEMIN OPHTHALMOL
JI Semin. Ophthalmol.
PD FEB 17
PY 2019
VL 34
IS 2
BP 98
EP 105
DI 10.1080/08820538.2019.1584227
PG 8
WC Ophthalmology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Ophthalmology
GA HQ0MW
UT WOS:000462090200008
PM 30835589
DA 2025-06-11
ER

PT J
AU Ho, MY
   Wen, MS
   Yeh, JK
   Hsieh, IC
   Chen, CC
   Hsieh, MJ
   Tsai, ML
   Yang, CH
   Wu, VCC
   Hung, KC
   Wang, CC
   Wang, CY
AF Ho, Ming-Yun
   Wen, Ming-Shien
   Yeh, Jih-Kai
   Hsieh, I-Chang
   Chen, Chun-Chi
   Hsieh, Ming-Jer
   Tsai, Ming-Lung
   Yang, Chia-Hung
   Wu, Victor Chien-Chia
   Hung, Kuo-Chun
   Wang, Chun-Chieh
   Wang, Chao-Yung
TI Excessive irisin increases oxidative stress and apoptosis in murine
   heart
SO BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
LA English
DT Article
DE Irisin; Reactive oxygen species; Mitochondria; Apoptosis
ID ACUTE MYOCARDIAL-INFARCTION; OSTEOPOROTIC FRACTURES; CIRCULATING IRISIN;
   BODY-COMPOSITION; EXERCISE; MITOCHONDRIA; ACTIVATION; EXPRESSION;
   REHABILITATION; THERMOGENESIS
AB Irisin is an exercise-related myokine. The abundance of irisin is associated with many diseases, such as myocardial infarction, chronic kidney disease, metabolic syndrome, obesity, and diabetes mellitus. In cardiomyocytes, irisin modulates the mitochondrial thermogenesis, regulates ischemic responses, and affects calcium signaling. Previous studies suggested that irisin increases cardiomyoblast mitochondrial functions and protects ischemic and reperfusion injury in ex vivo murine heart. In human, clinical studies have shown that acute myocardial infarction patients with more elevated serum irisin abundances are associated with increased major adverse cardiovascular events. However, the mechanisms responsible for this discrepancy between in myocardial infarction patients and ex vivo murine heart is unclear. Based on the clinical observations, we hypothesized that excessive irisin might lead to mitochondrial dysfunctions and cardiomyocyte damages. Our data showed that overexpression of irisin in mice with the adenovirus resulted in enhanced mitochondrial respiration with a higher oxygen consumption rate. Enhanced irisin expression in heart and irisin treatment in cardiomyocytes increased reactive oxygen species production. Furthermore, irisin treatment in cardiomyocytes enhanced the apoptosis and the cleaved caspase 9 levels in hypoxic condition. Pathway analysis in the murine heart with the over expression of irisin showed that angiopoietin-Tie2, IL-8, IL-13, TGF-beta, and thrombopoietin signaling were affected by irisin. Collectively, these results supported that excessive irisin causes mitochondrial overdrive with a higher reactive oxygen species production, which results in increased apoptosis of cardiomyocytes in a hypoxic environment. (C) 2018 Elsevier Inc. All rights reserved.
C1 [Ho, Ming-Yun; Wen, Ming-Shien; Yeh, Jih-Kai; Hsieh, I-Chang; Chen, Chun-Chi; Hsieh, Ming-Jer; Tsai, Ming-Lung; Yang, Chia-Hung; Wu, Victor Chien-Chia; Hung, Kuo-Chun; Wang, Chun-Chieh; Wang, Chao-Yung] Chang Gung Univ, Coll Med, Chang Gung Mem Hosp, Dept Cardiol, Taoyuan, Taiwan.
C3 Chang Gung Memorial Hospital; Chang Gung University
RP Wen, MS; Wang, CY (corresponding author), 5 Fu Hsing St, Taoyuan 333, Taiwan.
EM wenms123@gmail.com; cwang@ocean.ag
RI Hsu, Yu-Chun/JEF-5013-2023; Lin, Wei-Shiang/ABA-7928-2020; Tsai,
   Minglung/LRB-8122-2024; Wang, Chao-Yung/ABA-6757-2021; Chen,
   chun-chi/KAM-0791-2024; Hsieh, Ming-Jer/M-1340-2013; Wu, Victor
   Chien-Chia/ABB-6872-2021; Wang, Chao-Yung/C-1001-2011
OI Wang, Chao-Yung/0000-0003-1546-7298
FU National Health Research Institutes [NHRI-EX106-10617SI]; National
   Science Council [105-2628-B-182-009-MY4]; Chang Gung Memorial Hospital
   [CMRPG3H0131, CMRPG3H0271, CMRPG3H0841, CMRPG3E1853, CMRPG3E1893]
FX This work was supported by the National Health Research Institutes
   NHRI-EX106-10617SI (C.Y.W), National Science Council
   105-2628-B-182-009-MY4 (C.Y.W), and Chang Gung Memorial Hospital
   CMRPG3H0131, CMRPG3H0271, CMRPG3H0841, CMRPG3E1853, and CMRPG3E1893
   (C.Y.W. and M.S.W.).
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NR 46
TC 33
Z9 34
U1 3
U2 23
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0006-291X
EI 1090-2104
J9 BIOCHEM BIOPH RES CO
JI Biochem. Biophys. Res. Commun.
PD SEP 18
PY 2018
VL 503
IS 4
BP 2493
EP 2498
DI 10.1016/j.bbrc.2018.07.005
PG 6
WC Biochemistry & Molecular Biology; Biophysics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics
GA GT8MM
UT WOS:000444791600044
PM 30208516
DA 2025-06-11
ER

PT J
AU Oseini, AM
   Cole, BK
   Issa, D
   Feaver, RE
   Sanyal, AJ
AF Oseini, Abdul M.
   Cole, Banumathi K.
   Issa, Danny
   Feaver, Ryan E.
   Sanyal, Arun J.
TI Translating scientific discovery: the need for preclinical models of
   nonalcoholic steatohepatitis
SO HEPATOLOGY INTERNATIONAL
LA English
DT Review
DE Non-alcoholic fatty liver disease (NAFLD); Non-alcoholic steatohepatitis
   (NASH); Organotypic liver system; Lipitoxic system; Diet induced animal
   model of non-alcoholic fatty liver disease (DIAMOND); Farnesoid X
   receptor (FXR)
ID FATTY LIVER-DISEASE; IN-VITRO MODEL; MOLECULAR-MECHANISMS; HUMAN
   HEPATOCYTES; OBETICHOLIC ACID; ANIMAL-MODEL; DRUG; CHALLENGES;
   COCULTURE; CELLS
AB Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in the Western world, affecting about 1/3 of the US general population and remaining as a significant cause of morbidity and mortality. The hallmark of the disease is the excessive accumulation of fat within the liver cells (hepatocytes), which eventually paves the way to cellular stress, injury and apoptosis. NAFLD is strongly associated with components of the metabolic syndrome and is fast emerging as a leading cause of liver transplant in the USA. Based on clinico-pathologic classification, NAFLD may present as isolated lipid collection (steatosis) within the hepatocytes (referred to as non-alcoholic fatty liver; NAFL); or as the more aggressive phenotype (known as non-alcoholic steatohepatitis; NASH). There are currently no regulatory agency- approved medication for NAFLD, despite the enormous work and resources that have gone into the study of this condition. Therefore, there remains a huge unmet need in developing and utilizing pre-clinical models that will recapitulate the disease condition in humans. In line with progress being made in developing appropriate disease models, this review highlights the cutting-edge preclinical in vitro and animal models that try to recapitulate the human disease pathophysiology and/or clinical manifestations.
C1 [Oseini, Abdul M.; Issa, Danny; Sanyal, Arun J.] VCU, Div Gastroenterol, Dept Med, Sch Med, MCV Box 980341, Richmond, VA 23298 USA.
   [Cole, Banumathi K.; Feaver, Ryan E.] HemoShear Therapeut, 501 Locust Ave,Suite 301, Charlottesville, VA 22902 USA.
   [Sanyal, Arun J.] Physiol & Mol Pathol, MCV Box 980341, Richmond, VA 23298 USA.
C3 Virginia Commonwealth University
RP Oseini, AM (corresponding author), VCU, Div Gastroenterol, Dept Med, Sch Med, MCV Box 980341, Richmond, VA 23298 USA.
EM abdul.oseini@vcuhealth.org; arun.sanyal@vcuhealth.org
FU National Institute of Diabetes and Digestive and Kidney Diseases [RO1 DK
   105961]; NIH HHS/United States [National Institute of Diabetes and
   Digestive and Kidney Diseases (US)] [T32 DK007150/DK/NIDDK]; SBIR,
   HemoShear Therapeutics [R44 DK115301]
FX Support: RO1 DK 105961 (National Institute of Diabetes and Digestive and
   Kidney Diseases). T32 DK007150/DK/NIDDK NIH HHS/United States [National
   Institute of Diabetes and Digestive and Kidney Diseases (US)]. R44
   DK115301 (SBIR, HemoShear Therapeutics).
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NR 54
TC 26
Z9 27
U1 0
U2 16
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1936-0533
EI 1936-0541
J9 HEPATOL INT
JI Hepatol. Int.
PD JAN
PY 2018
VL 12
IS 1
BP 6
EP 16
DI 10.1007/s12072-017-9838-6
PG 11
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA FW4YD
UT WOS:000425321100002
PM 29299759
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Kruse, M
   Fiallo, A
   Tao, JL
   Susztak, K
   Amann, K
   Katz, EB
   Charron, MJ
AF Kruse, Michael
   Fiallo, Ariana
   Tao, Jianling
   Susztak, Katalin
   Amann, Kerstin
   Katz, Ellen B.
   Charron, Maureen J.
TI A High Fat Diet During Pregnancy and Lactation Induces Cardiac and Renal
   Abnormalities in GLUT4+/- Male Mice
SO KIDNEY & BLOOD PRESSURE RESEARCH
LA English
DT Article
DE Cardiorenal Syndrome; Fetal Programming; GLUT4; High Fat Diet;
   Hypertension
ID RENIN-ANGIOTENSIN SYSTEM; NITRIC-OXIDE SYNTHASE; FETAL GENE PROGRAM;
   CARDIORENAL SYNDROME; METABOLIC SYNDROME; OXIDATIVE STRESS; IN-UTERO;
   INSULIN-RESISTANCE; NEPHRON NUMBER; KNOCKOUT MICE
AB Background/Aims: Altered nutrients during the in utero (IU) and/or lactation (L) period predispose offspring to cardio-renal diseases in adulthood. This study investigates the effect of a high fat diet (HFD) fed to female mice during IU/L on gene expression patterns associated with heart and kidney failure and hypertension in male offspring. Methods: Female wild type (WT) mice were fed either a HFD or control chow (C) prior to mating with males with a genetic heterozygous deletion of GLUT4 (G4+/-, a model of peripheral insulin resistance and hypertension) and throughout IU/L. After weaning male offspring were placed on a standard rodent chow until 24 weeks of age. Results: All offspring exposed to a maternal HFD showed increased heart and kidney weight and reduced cardiac insulin responsiveness. G4+/- offspring on a HFD displayed early hypertension associated with increased renal gene expression of renin and the AT(1)- receptors compared to G4+/- on a C diet. This group showed decreased cardiac expression of key genes involved in fatty acid oxidation compared to WT on a C diet. Conclusions: These results indicate an interaction between a HFD diet and genotype during early life development that can enhance susceptibility to cardio-renal diseases later in life. (C) 2017 The Author(s) Published by S. Karger AG, Basel
C1 [Kruse, Michael; Fiallo, Ariana; Katz, Ellen B.; Charron, Maureen J.] Albert Einstein Coll Med, Dept Biochem, 1300 Morris Pk Ave, Bronx, NY 10461 USA.
   [Charron, Maureen J.] Albert Einstein Coll Med, Dept Med, Bronx, NY 10461 USA.
   [Charron, Maureen J.] Albert Einstein Coll Med, Dept Obstet & Gynecol & Womens Hlth, Bronx, NY 10461 USA.
   [Tao, Jianling; Susztak, Katalin] Univ Penn, Dept Med, Renal Electrolyte & Hypertens Div, Philadelphia, PA 19104 USA.
   [Amann, Kerstin] Univ Erlangen Nurnberg, Dept Pathol, Nephropathol, Erlangen, Germany.
C3 Yeshiva University; Montefiore Medical Center; Albert Einstein College
   of Medicine; Yeshiva University; Montefiore Medical Center; Albert
   Einstein College of Medicine; Montefiore Medical Center; Albert Einstein
   College of Medicine; Yeshiva University; University of Pennsylvania;
   University of Erlangen Nuremberg
RP Charron, MJ (corresponding author), Albert Einstein Coll Med, Dept Biochem, 1300 Morris Pk Ave, Bronx, NY 10461 USA.
EM maureen.charron@einstein.yu.edu
RI Susztak, Katalin/ABE-7474-2021
OI Susztak, Katalin/0000-0002-1005-3726
FU National Institutes of Health [R21 DK081194]; Diabetes Action
   Foundation; American Diabetes Association; National Natural Sciences
   Foundation of China [81170665]; National Institutes of Health (Diabetes
   Research and Training Center) [P60 DK020541]; National Institutes of
   Health (Epigenomics, Liver, O'Brien Kidney, and Comprehensive Cancer
   Centers of Albert Einstein College of Medicine)
FX This work was supported by National Institutes of Health (R21 DK081194
   to MJC, Diabetes Research and Training Center P60 DK020541, Epigenomics,
   Liver, O'Brien Kidney, and Comprehensive Cancer Centers of Albert
   Einstein College of Medicine), Diabetes Action Foundation (to MJC and
   MK) and American Diabetes Association (to MJC). JT has received grant
   support from the National Natural Sciences Foundation of China (ref. no.
   81170665).
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NR 58
TC 6
Z9 6
U1 1
U2 4
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1420-4096
EI 1423-0143
J9 KIDNEY BLOOD PRESS R
JI Kidney Blood Pressure Res.
PY 2017
VL 42
IS 3
BP 468
EP 482
DI 10.1159/000479383
PG 15
WC Physiology; Urology & Nephrology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology; Urology & Nephrology; Cardiovascular System & Cardiology
GA FM4GA
UT WOS:000414970500008
PM 28750406
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Novotny, D
   Karasek, D
   Vaverkova, H
   Bartkova, M
   Kubickova, V
AF Novotny, Dalibor
   Karasek, David
   Vaverkova, Helena
   Bartkova, Margita
   Kubickova, Veronika
TI Paraoxonase 2 Cys311Ser polymorphism and its association with the
   systolic blood pressure values in asymptomatic dyslipidemic individuals:
   a pilot study
SO LABORATORIUMSMEDIZIN-JOURNAL OF LABORATORY MEDICINE
LA English
DT Article
DE apolipoprotein A5; apolipoprotein E; dyslipidemia; genetic polymorphism;
   paraoxonase 2
ID APOLIPOPROTEIN A5 T-1131C; METABOLIC SYNDROME; ADHESION MOLECULES;
   GENETIC-VARIANTS; ENDOTHELIAL DYSFUNCTION; CARDIOVASCULAR-DISEASE;
   COMMON POLYMORPHISMS; DIABETES-MELLITUS; OXIDATIVE STRESS; RISK
AB Background: The study aimed to evaluate the relationship of paraoxonase 2 (PON2) gene Cys311Ser variants with blood pressure values, endothelial/hemostatic marker levels, and other laboratory parameters in asymptomatic dyslipidemic subjects. The same analyses were also performed with the common variants of PON2 Cys311Ser and -T1131C apolipoprotein A5 (ApoA5) polymorphisms, and PON2 Cys311Ser and apolipoprotein E (ApoE) polymorphisms.
   Methods: Two hundred and sixty-four individuals were included in the study. The laboratory parameters were assessed by routine kit methods, while methods based on polymerase chain reaction were used for PON2, ApoA5, and ApoE genotyping.
   Results: PON2 311 SS homozygous individuals had significantly lower systolic blood pressure values (SBP, p < 0.01), C-reactive protein, and apolipoprotein A1 levels (p < 0.05), as compared with C allele carriers. The analysis revealed no differences in the levels of endothelial/hemostatic markers, except for the increased adhesion molecule [soluble vascular cell adhesion molecule 1 (sVCAM-1)] concentrations in 311S/E2 carriers (p < 0.05). PON2 311S subjects showed the lowest values of SBP in combination with "neutral" ApoE3 allele (p < 0.05).
   Conclusions: The presence of the PON2 311 C variant could represent an elevated risk of atherosclerotic complications in asymptomatic dyslipidemic individuals. Nevertheless, considering the study limitations, these relationships are necessary to be confirmed in further research.
C1 [Novotny, Dalibor] Univ Hosp Olomouc, Dept Clin Biochem, Olomouc 77520, Czech Republic.
   [Bartkova, Margita; Kubickova, Veronika] Univ Hosp Olomouc, Dept Clin Biochem, Olomouc, Czech Republic.
   [Karasek, David; Vaverkova, Helena] Palacky Univ, Fac Med & Dent, Dept Internal Med 3, CR-77147 Olomouc, Czech Republic.
   [Karasek, David; Vaverkova, Helena] Univ Hosp Olomouc, Olomouc 77520, Czech Republic.
C3 University Hospital Olomouc; University Hospital Olomouc; Palacky
   University Olomouc; University Hospital Olomouc
RP Novotny, D (corresponding author), Univ Hosp Olomouc, Dept Clin Biochem, IP Pavlova 6, Olomouc 77520, Czech Republic.
EM dalibor.novotny@fnol.cz
RI Kučerová, Veronika/AAQ-7095-2021
OI Karasek, David/0000-0002-9309-4952; Kucerova,
   Veronika/0000-0002-7707-9680
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NR 39
TC 0
Z9 0
U1 0
U2 4
PU WALTER DE GRUYTER GMBH
PI BERLIN
PA GENTHINER STRASSE 13, D-10785 BERLIN, GERMANY
SN 0342-3026
EI 1439-0477
J9 LABORATORIUMSMEDIZIN
JI LaboratoriumsMedizin
PD JUL
PY 2015
VL 39
IS 4
BP 249
EP 257
DI 10.1515/labmed-2015-0009
PG 9
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA CO6UL
UT WOS:000359291800006
OA hybrid
DA 2025-06-11
ER

PT J
AU Cecconello, AL
   Trapp, M
   Hoefel, AL
   Marques, CV
   Arbo, BD
   Osterkamp, G
   Kucharski, LCR
   Ribeiro, MFM
AF Cecconello, Ana Lucia
   Trapp, Marcia
   Hoefel, Ana Lucia
   Marques, Claudia Vieira
   Arbo, Bruno Dutra
   Osterkamp, Gabriela
   Rios Kucharski, Luiz Carlos
   Marques Ribeiro, Maria Flavia
TI Sex-related differences in the effects of high-fat diets on DHEA-treated
   rats
SO ENDOCRINE
LA English
DT Article
DE DHEA; Sexual dimorphism; Metabolic risk; Insulin sensitivity; Liver
ID METABOLIC SYNDROME; INSULIN-RESISTANCE; ADIPOSE-TISSUE; DIABETIC-RATS;
   DEHYDROEPIANDROSTERONE-SULFATE; VISCERAL OBESITY; OXIDATIVE STRESS;
   SKELETAL-MUSCLE; SENSITIVITY; LIVER
AB Several studies have investigated the beneficial effects of dehydroepiandrosterone (DHEA) on lipid and glucose metabolism. However, many of these studies are inconclusive about the effects of DHEA administration on metabolic disorders, and there appear to be sex-related differences in the effects of DHEA treatment. Few animal studies have addressed the effects of DHEA on diet-induced metabolic disorders. The present study sought to ascertain whether sex differences exist in the effects of a high-fat diet (HFD) on weight gain, adiposity, and biochemical and hormonal parameters in DHEA-treated rats. Rats were fed a HFD for 4 weeks and simultaneously received treatment with DHEA (10 mg/kg by subcutaneous injection) once weekly. Body weight, retroperitoneal fat depot weight, serum glucose, insulin, and leptin levels, and hepatic lipids were measured. HFD exposure increased the adiposity index in both sexes, the hepatic triglyceride content in both sexes, and the hepatic total cholesterol level in males. Moreover, the HFD induced an increase in blood glucose levels in both sexes, and hyperinsulinemia in males. In this experimental model, DHEA treatment reduced hepatic triglyceride levels only in females, regardless of HFD exposure. Exposure to a HFD, even if it does not cause obesity, may enhance risk factors for metabolic disorders, and males are more sensitive to this effect. DHEA treatment can help prevent metabolic derangements, but its effect varies with sex.
C1 [Cecconello, Ana Lucia; Hoefel, Ana Lucia; Marques, Claudia Vieira; Arbo, Bruno Dutra; Osterkamp, Gabriela; Marques Ribeiro, Maria Flavia] Univ Fed Rio Grande do Sul, Inst Ciencias Basicas Saude, Dept Fisiol, Lab Interacao Neurohumoral, BR-90050170 Porto Alegre, RS, Brazil.
   [Trapp, Marcia; Hoefel, Ana Lucia; Rios Kucharski, Luiz Carlos] Univ Fed Rio Grande do Sul, Inst Ciencias Basicas Saude, Dept Fisiol, Lab Metab & Endocrinol Comparada, BR-90050170 Porto Alegre, RS, Brazil.
C3 Universidade Federal do Rio Grande do Sul; Universidade Federal do Rio
   Grande do Sul
RP Cecconello, AL (corresponding author), Univ Fed Rio Grande do Sul, Inst Ciencias Basicas Saude, Dept Fisiol, Lab Interacao Neurohumoral, Ave Sarmento Leite 500, BR-90050170 Porto Alegre, RS, Brazil.
EM analuciacecconello@gmail.com
RI Hoefel, Ana/Y-3226-2019; Arbo, Bruno/T-2263-2017; Kucharski,
   Luiz/AAC-2036-2020
OI Kucharski, Luiz Carlos/0000-0002-7868-8840; Arbo,
   Bruno/0000-0001-7929-1688; Marques Ribeiro, Maria
   Flavia/0000-0002-2265-7332
FU CAPES; CNPq
FX This work was supported by the Brazilian research agencies CAPES and
   CNPq.
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NR 54
TC 13
Z9 14
U1 0
U2 13
PU HUMANA PRESS INC
PI TOTOWA
PA 999 RIVERVIEW DRIVE SUITE 208, TOTOWA, NJ 07512 USA
SN 1355-008X
EI 1559-0100
J9 ENDOCRINE
JI Endocrine
PD APR
PY 2015
VL 48
IS 3
BP 985
EP 994
DI 10.1007/s12020-014-0396-6
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA CE2QT
UT WOS:000351661100033
PM 25300783
DA 2025-06-11
ER

PT J
AU Hu, Y
   Chen, B
   Qian, J
   Jin, L
   Jin, T
   Lu, D
AF Hu, Y.
   Chen, B.
   Qian, J.
   Jin, L.
   Jin, T.
   Lu, D.
TI Occupational coke oven emissions exposure and risk of abnormal liver
   function: modifications of body mass index and hepatitis virus infection
SO OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
LA English
DT Article
ID POLYCYCLIC AROMATIC-HYDROCARBONS; OXIDATIVE STRESS; METABOLIC SYNDROME;
   SERUM; OBESITY; WORKERS; PYRENE; RATS
AB Objectives Occupational coke oven emissions (COEs) have been considered an important health issue. However, there are no conclusive data on human hepatic injury due to COE exposure. The association of COE exposure with liver function was explored and the effects of modification of potential non-occupational factors were assessed.
   Methods 705 coke oven workers and 247 referents were investigated. Individual cumulative COE exposure was quantitatively estimated. Serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma-glutamyl transferase, alkaline phosphatase, hepatitis B surface antigen and anti-hepatitis C antibody were measured.
   Results Among those with high COE exposure, the adjusted ORs of abnormal ALT and AST were 5.23 (95% CI 2.66 to 10.27) and 1.95 (95% CI 1.18 to 3.52), respectively. Overweight individuals (body mass index (BMI) >= 25 kg/m(2)) with high COE exposure had elevated risks of abnormal ALT (adjusted OR 23.93, 95% CI 8.73 to 65.62) and AST (adjusted OR 5.18, 95% CI 2.32 to 11.58). Risk of liver damage in hepatitis B virus-or hepatitis C virus-positive individuals with COE exposure was also elevated.
   Conclusions Long-term exposure to COE increases the risk of liver dysfunction, which is more prominent among those with higher BMI and hepatitis virus infection. The risk assessment of liver damage associated with COE exposure should take BMI and hepatitis virus infection into consideration.
C1 [Hu, Y.] Fudan Univ, Dept Occupat & Environm Hlth, Sch Publ Hlth, Shanghai 200032, Peoples R China.
   [Hu, Y.] Wake Forest Univ, Bowman Gray Sch Med, Dept Pathol, Winston Salem, NC 27103 USA.
   [Qian, J.; Jin, L.; Lu, D.] Fudan Univ, State Key Lab Genet Engn, Shanghai 200032, Peoples R China.
   [Qian, J.; Jin, L.; Lu, D.] Fudan Univ, MOE Key Lab Contemporary Anthropol, Inst Genet, Sch Life Sci, Shanghai 200032, Peoples R China.
C3 Fudan University; Wake Forest University; Wake Forest Baptist Medical
   Center; Fudan University; Fudan University
RP Hu, Y (corresponding author), Fudan Univ, Dept Occupat & Environm Hlth, Sch Publ Hlth, Shanghai 200032, Peoples R China.
EM yphu@shmu.edu.cn
RI Jin, Li/M-5063-2019
OI Jin, Li/0000-0001-9201-2321
FU China National Key Basic Research Program [2002CB512902]
FX This work was supported by the China National Key Basic Research Program
   Grants (2002CB512902).
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NR 27
TC 13
Z9 13
U1 0
U2 6
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 1351-0711
EI 1470-7926
J9 OCCUP ENVIRON MED
JI Occup. Environ. Med.
PD MAR
PY 2010
VL 67
IS 3
BP 159
EP 165
DI 10.1136/oem.2009.047316
PG 7
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA 567LG
UT WOS:000275447500005
PM 19773278
DA 2025-06-11
ER

PT J
AU Sarafidis, PA
   Ruilope, LM
AF Sarafidis, Pantelis A.
   Ruilope, Luis M.
TI Insulin resistance, hyperinsulinemia, and renal injury: Mechanisms and
   implications
SO AMERICAN JOURNAL OF NEPHROLOGY
LA English
DT Review
DE insulin resistance; insulin; hyperinsulinemia; kidney; renal injury
ID GROWTH-FACTOR-I; GLOMERULAR MESANGIAL CELLS; CHRONIC KIDNEY-DISEASE;
   SMOOTH-MUSCLE-CELLS; DEPENDENT DIABETES-MELLITUS; IMPAIRED
   GLUCOSE-TOLERANCE; URINARY ALBUMIN EXCRETION; PLASMINOGEN-ACTIVATOR
   INHIBITOR-1; ANGIOTENSINOGEN GENE-EXPRESSION; HUMAN ENDOTHELIAL-CELLS
AB Most of the basic components of the metabolic syndrome, namely type 2 diabetes mellitus, hypertension, obesity, or low high-density lipoprotein cholesterol levels, apart from being major risk factors for cardiovascular disease have been also associated with an increased risk of chronic kidney disease. However, several epidemiologic studies conducted over the past years suggest that the central component of the syndrome, insulin resistance, as well as compensatory hyperinsulinemia are independently associated with an increased prevalence of chronic kidney disease. In addition, background studies support the existence of several pathways linking insulin resistance and hyperinsulinemia with kidney damage. Insulin per se promotes the proliferation of renal cells and stimulates the production of other important growth factors such as insulin-like growth factor-1 and transforming growth factor beta. Insulin also upregulates the expression of angiotensin 11 type 1 receptor in mesangial cells, thus enhancing the deleterious effects of angiotensin 11 in the kidney, and stimulates production and renal action of endothelin-1. Moreover, insulin resistance and hyperinsulinemia are associated with decreased endothelial production of nitric oxide and increased oxidative stress which have been also implicated in the progression of diabetic nephropathy. This review analyzes the above and other potential mechanisms, through which insulin resistance and hyperinsulinemia can contribute to renal injury. Copyright (c) 2006 S. Karger AG, Basel.
C1 Rush Univ, Med Ctr, Dept Prevent Med, Hypertens Clin Res Ctr, Chicago, IL 60612 USA.
   Hosp 12 Octubre, Hypertens Unit, E-28041 Madrid, Spain.
C3 Rush University; Hospital Universitario 12 de Octubre
RP Sarafidis, PA (corresponding author), Rush Univ, Med Ctr, Dept Prevent Med, Hypertens Clin Res Ctr, 1700 W Van Buren,Suite 470, Chicago, IL 60612 USA.
EM psarafidis11@yahoo.gr
RI Ruilope, Luis/O-1673-2018; Sarafidis, Pantelis/AFO-2131-2022
OI Sarafidis, Pantelis/0000-0002-9174-4018; Ruilope, Luis
   M/0000-0001-6278-7951
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NR 149
TC 218
Z9 232
U1 1
U2 18
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0250-8095
EI 1421-9670
J9 AM J NEPHROL
JI Am. J. Nephrol.
PY 2006
VL 26
IS 3
BP 232
EP 244
DI 10.1159/000093632
PG 13
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 066CF
UT WOS:000239206600003
PM 16733348
DA 2025-06-11
ER

PT J
AU Kalyesubula, M
   Mopuri, R
   Asiku, J
   Rosov, A
   Yosefi, S
   Edery, N
   Bocobza, S
   Moallem, U
   Dvir, H
AF Kalyesubula, Mugagga
   Mopuri, Ramgopal
   Asiku, Jimmy
   Rosov, Alexander
   Yosefi, Sara
   Edery, Nir
   Bocobza, Samuel
   Moallem, Uzi
   Dvir, Hay
TI High-dose vitamin B1 therapy prevents the development of experimental
   fatty liver driven by overnutrition
SO DISEASE MODELS & MECHANISMS
LA English
DT Article
DE Thiamine; Steatosis; Fatty liver; Obesity; Metabolic syndrome; NAFLD;
   Insulin resistance
ID DROPLET-ASSOCIATED PROTEINS; NONALCOHOLIC STEATOHEPATITIS; LIPID
   DROPLETS; THIAMINE SUPPLEMENTATION; INSULIN-RESISTANCE; HEPATIC
   STEATOSIS; OXIDATIVE STRESS; DISEASE; METABOLISM; PREVALENCE
AB Fatty liver is an abnormal metabolic condition of excess intrahepatic fat. This condition, referred to as hepatic steatosis, is tightly associated with chronic liver disease and systemic metabolic morbidity. The most prevalent form in humans, i.e. non-alcoholic fatty liver, generally develops due to overnutrition and sedentary lifestyle, and has as yet no approved drug therapy. Previously, we have developed a relevant large-animal model in which overnourished sheep raised on a high-calorie carbohydrate-rich diet develop hyperglycemia, hyperinsulinemia, insulin resistance, and hepatic steatosis. Here, we tested the hypothesis that treatment with thiamine (vitamin B1) can counter the development of hepatic steatosis driven by overnutrition. Remarkably, the thiamine-treated animals presented with completely normal levels of intrahepatic fat, despite consuming the same amount of liver-fattening diet. Thiamine treatment also decreased hyperglycemia and increased the glycogen content of the liver, but it did not improve insulin sensitivity, suggesting that steatosis can be addressed independently of targeting insulin resistance. Thiamine increased the catalytic capacity for hepatic oxidation of carbohydrates and fatty acids. However, at gene-expression levels, more-pronounced effects were observe donlipid-droplet formation and lipidation of very-low-density lipoprotein, suggesting that thiamine affects lipid metabolism not only through its known classic coenzyme roles. This discovery of the potent anti-steatotic effect of thiamine may prove clinically useful in managing fatty liver-related disorders.
C1 [Kalyesubula, Mugagga; Mopuri, Ramgopal; Asiku, Jimmy; Rosov, Alexander; Yosefi, Sara; Moallem, Uzi; Dvir, Hay] Agr Res Org ARO, Inst Anim Sci, Volcani Ctr, IL-7528809 Rishon Leziyyon, Israel.
   [Kalyesubula, Mugagga] Hebrew Univ Jerusalem, Dept Anim Sci, IL-7610001 Rehovot, Israel.
   [Asiku, Jimmy] Hebrew Univ Jerusalem, Inst Biochem Food Sci & Nutr, IL-7610001 Rehovot, Israel.
   [Edery, Nir] Kimron Vet Inst, Vet Serv, Pathol Lab, IL-50250 Rishon Leziyyon, Israel.
   [Bocobza, Samuel] Volcani Ctr ARO, Inst Plant Sci, IL-7528809 Rishon Leziyyon, Israel.
C3 VOLCANI INSTITUTE OF AGRICULTURAL RESEARCH; Hebrew University of
   Jerusalem; Hebrew University of Jerusalem; Kimron Veterinary Institute;
   VOLCANI INSTITUTE OF AGRICULTURAL RESEARCH
RP Dvir, H (corresponding author), Agr Res Org ARO, Inst Anim Sci, Volcani Ctr, IL-7528809 Rishon Leziyyon, Israel.
EM haydvir@volcani.agri.gov.il
RI Dvir, Hay/AAS-8041-2020; Kalyesubula, Mugagga/JVO-7219-2024; mopuri,
   ramgopal/R-8096-2016
OI Dvir, Hay/0000-0002-5024-5626; Kalyesubula, Mugagga/0000-0002-1100-263X;
   Bocobza, Samuel/0000-0002-8138-4426; Moallem, Uzi/0000-0001-7958-0885;
   mopuri, ramgopal/0000-0002-8666-657X
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NR 69
TC 19
Z9 21
U1 1
U2 8
PU COMPANY BIOLOGISTS LTD
PI CAMBRIDGE
PA BIDDER BUILDING, STATION RD, HISTON, CAMBRIDGE CB24 9LF, ENGLAND
SN 1754-8403
EI 1754-8411
J9 DIS MODEL MECH
JI Dis. Model. Mech.
PD MAR
PY 2021
VL 14
IS 3
AR dmm048355
DI 10.1242/dmm.048355
PG 11
WC Cell Biology; Medicine, Research & Experimental; Pathology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Research & Experimental Medicine; Pathology
GA UN4RG
UT WOS:000694003000005
PM 33608323
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU El-Missiry, MA
   El-Missiry, ZMA
   Othman, AI
AF El-Missiry, Mohamed A.
   El-Missiry, Ziad M. A.
   Othman, Azza I.
TI Melatonin is a potential adjuvant to improve clinical outcomes in
   individuals with obesity and diabetes with coexistence of Covid-19
SO EUROPEAN JOURNAL OF PHARMACOLOGY
LA English
DT Article
DE Covid-19; SARS-CoV-2; Melatonin; Obesity; Diabetes mellitus;
   Inflammation
ID DOUBLE-BLIND; CORONAVIRUS; ANTIOXIDANT; MELLITUS; DISEASE; PLACEBO;
   WUHAN
AB Coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a newly discovered highly pathogenic virus that was declared pandemic in March 2020 by the World Health Organization. The virus affects the respiratory system, produces an inflammatory storm that causes lung damage and respiratory dysfunction. It infects humans of all ages. The Covid-19 takes a more severe course in individuals with chronic metabolic diseases such as obesity, diabetes mellitus, and hypertension. This category of persons exhibits weak immune activity and decreased levels of endogenous antioxidants. Melatonin is a multifunctional signaling hormone synthesized and secreted primarily by the pineal gland. It is a potent antioxidant with immunomodulatory action and has remarkable anti-inflammatory effects under a variety of circumstances. Regarding Covid-19 and metabolic syndrome, adequate information about the relationship between these two comorbidities is required for better management of these patients. Since Covid-19 infection and complications involve severe inflammation and oxidative stress in people with obesity and diabetes, we anticipated the inclusion of melatonin, as powerful antioxidant, within proposed treatment protocols. In this context, melatonin is a potential and promising agent to help overcome Covid-19 infection and boost the immune system in healthy persons and obese and diabetic patients. This review summarizes some evidence from recently published reports on the utility of melatonin as a potential adjuvant in Covid-19-infected individuals with diabetes and obesity.
C1 [El-Missiry, Mohamed A.; Othman, Azza I.] Mansoura Univ, Fac Sci, Dept Zool, Mansoura, Egypt.
   [El-Missiry, Ziad M. A.] Mansoura Univ, Fac Dent, Dept Oromaxillofacial Surg, Mansoura, Egypt.
C3 Egyptian Knowledge Bank (EKB); Mansoura University; Egyptian Knowledge
   Bank (EKB); Mansoura University
RP El-Missiry, MA (corresponding author), Mansoura Univ, Fac Sci, Dept Zool, Mansoura, Egypt.
EM maelmissiry@yahoo.com
RI othman, azza/O-3828-2018; El-Missiry, Mohamed Amr/L-9850-2018
OI El-Missiry, Mohamed Amr/0000-0002-4566-0497
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NR 77
TC 53
Z9 54
U1 0
U2 21
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0014-2999
EI 1879-0712
J9 EUR J PHARMACOL
JI Eur. J. Pharmacol.
PD SEP 5
PY 2020
VL 882
AR 173329
DI 10.1016/j.ejphar.2020.173329
PG 6
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA NB6ZK
UT WOS:000560663000007
PM 32615182
OA Green Published
DA 2025-06-11
ER

PT J
AU Mahli, A
   Seitz, T
   Beckröge, T
   Freese, K
   Thasler, WE
   Benkert, M
   Dietrich, P
   Weiskirchen, R
   Bosserhoff, A
   Hellerbrand, C
AF Mahli, Abdo
   Seitz, Tatjana
   Beckroege, Tobias
   Freese, Kim
   Thasler, Wolfgang Erwin
   Benkert, Matthias
   Dietrich, Peter
   Weiskirchen, Ralf
   Bosserhoff, Anja
   Hellerbrand, Claus
TI Bone Morphogenetic Protein-8B Expression is Induced in Steatotic
   Hepatocytes and Promotes Hepatic Steatosis and Inflammation In Vitro
SO CELLS
LA English
DT Article
DE BMP8B; steatosis; inflammation; NAFLD; non-alcoholic fatty liver disease
ID NF-KAPPA-B; NONALCOHOLIC STEATOHEPATITIS; LIPID-ACCUMULATION; BMP8B;
   HOMEOSTASIS; ACTIVATION; STRESS; CELLS; 8B
AB Non-alcoholic fatty liver disease (NAFLD) is considered to be the hepatic manifestation of the metabolic syndrome. The bone morphogenetic protein-8B (BMP8B) has been shown to be expressed in brown adipose tissues and the hypothalamus and to affect thermogenesis and susceptibility to diet-induced obesity. Here, we aimed to analyze BMP8B expression in NAFLD and to gain insight into BMP8B effects on pathophysiological steps of NAFLD progression. BMP8B mRNA and protein expression were dose-dependently induced in primary human hepatocytes in vitro upon incubation with fatty acids. Furthermore, hepatic BMP8B expression was significantly increased in a murine NAFLD model and in NAFLD patients compared with controls. Incubation with recombinant BMP8B further enhanced the fatty acid-induced cellular lipid accumulation as well as NFB activation and pro-inflammatory gene expression in hepatocytes, while siRNA-mediated BMP8B depletion ameliorated these fatty acid-induced effects. Analysis of the expression of key factors of hepatocellular lipid transport and metabolisms indicated that BMP8B effects on fatty acid uptake as well as de novo lipogenesis contributed to hepatocellular accumulation of fatty acids leading to increased storage in the form of triglycerides and enhanced combustion by beta oxidation. In conclusion, our data indicate that BMP8B enhances different pathophysiological steps of NAFLD progression and suggest BMP8B as a promising prognostic marker and therapeutic target for NAFLD and, potentially, also for other chronic liver diseases.
C1 [Mahli, Abdo; Seitz, Tatjana; Beckroege, Tobias; Freese, Kim; Benkert, Matthias; Dietrich, Peter; Bosserhoff, Anja; Hellerbrand, Claus] Friedrich Alexander Univ Erlangen Nurnberg, Inst Biochem, Emil Fischer Zentrum, Fahrstr 17, D-91054 Erlangen, Germany.
   [Thasler, Wolfgang Erwin] Hepacult GmbH, Klopferspitz 19, D-82152 Planegg Martinsried, Germany.
   [Weiskirchen, Ralf] RWTH Univ Hosp Aachen, Inst Mol Pathobiochem Expt Gene Therapy & Clin Ch, D-52074 Aachen, Germany.
C3 University of Erlangen Nuremberg; RWTH Aachen University; RWTH Aachen
   University Hospital
RP Hellerbrand, C (corresponding author), Friedrich Alexander Univ Erlangen Nurnberg, Inst Biochem, Emil Fischer Zentrum, Fahrstr 17, D-91054 Erlangen, Germany.
EM Abdo.mahli@fau.de; Tatjana.Seitz@fau.de; Tobias.Beckroege@fau.de;
   Kim.Freese@fau.de; Wolfgang.Thasler@swmbrk.de; Matthias.Benkert@fau.de;
   Peter.Dietrich@fau.de; rweiskirchen@ukaachen.de; Anja.Bosserhoff@fau.de;
   claus.hellerbrand@fau.de
RI Dietrich, Peter/NBX-2216-2025; Bosserhoff, Anja/GNH-4801-2022; Mahli,
   Abdo/AAD-4744-2019; Weiskirchen, Ralf/O-1734-2018
OI Mahli, Abdo/0000-0002-8333-7551; Weiskirchen, Ralf/0000-0003-3888-0931;
   Dietrich, Peter/0000-0003-2289-8600; Bosserhoff,
   Anja/0000-0001-8147-394X
FU German Research Association (DFG) [HE2458/14, BO1573]; German Cancer Aid
   (AKB); Interdisciplinary Center for Clinical Research (IZKF) Erlangen
   [D24, ELAN 17/4]
FX This work was supported by grants from the German Research Association
   (DFG) (HE2458/14; BO1573), the German Cancer Aid (AKB), and the
   Interdisciplinary Center for Clinical Research (IZKF) Erlangen (D24, to
   AB; ELAN 17/4, to CH).
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NR 43
TC 17
Z9 17
U1 0
U2 6
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2073-4409
J9 CELLS-BASEL
JI Cells
PD MAY
PY 2019
VL 8
IS 5
AR 457
DI 10.3390/cells8050457
PG 13
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA IC5FZ
UT WOS:000470994400077
PM 31096638
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Han, WH
   Gotzmann, J
   Kuny, S
   Huang, H
   Chan, CB
   Lemieux, H
   Sauvé, Y
AF Han, Woo Hyun
   Gotzmann, Jonathan
   Kuny, Sharee
   Huang, Hui
   Chan, Catherine B.
   Lemieux, Helene
   Sauve, Yves
TI Modifications in Retinal Mitochondrial Respiration Precede Type 2
   Diabetes and Protracted Microvascular Retinopathy
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Article
DE hyperinsulinemia; hyperglycemia; type 2 diabetes; animal model;
   oxidative phosphorylation
ID PHOTORECEPTOR CELLS; METABOLIC SYNDROME; OXIDATIVE STRESS; AMACRINE
   CELLS; ANIMAL-MODELS; RAT; DEATH; MICE; PHOSPHORYLATION; DYSFUNCTION
AB PURPOSE. To characterize retinal mitochondrial respiration associated with type 2 diabetes (T2D) progression in a cone-rich diurnal rodent, the Nile rat (genus Arvicanthis, species niloticus).
   METHODS. Nile rats were fed a standard rodent diet that resulted in rising glucose levels from 6 months. Age-matched control animals were fed a high-fiber diet that prevented diabetes up to 18 months. The functional status of specific retinal mitochondrial components and mitochondrial outer membrane integrity were studied by using high-resolution respirometry. Ocular complications were documented with funduscopy, electroretinography (ERG), and trypsin digestion of retinal vasculature.
   RESULTS. Mitochondrial functional changes were detected during hyperinsulinemia with maintained normoglycemia (2 months), corresponding to stage 1 of human T2D. Our data showed increased contribution of mitochondrial respiration through the NADH pathway relative to maximal oxidative phosphorylation capacity, with simultaneous electron entry into NADH (Complex I and related dehydrogenases) and succinate (Complex II) pathways. These compensatory events coincided with compromised mitochondrial outer membrane integrity. The first clinical sign of retinopathy (pericyte loss) was only detected at 12 months (after 6 months of sustained hyperglycemia) alongside a common ocular complication of diabetes, cataractogenesis. Further prolongation of hyperglycemia (from 12 to 18 months) led to capillary degeneration and delayed photopic ERG oscillatory potentials.
   CONCLUSIONS. Oxidative phosphorylation compensatory changes in the retina can be detected as early as 2 months, before development of hyperglycemia, and are associated with reduced mitochondrial outer membrane integrity.
C1 [Han, Woo Hyun; Kuny, Sharee; Sauve, Yves] Univ Alberta, Dept Ophthalmol & Visual Sci, Edmonton, AB, Canada.
   [Gotzmann, Jonathan; Huang, Hui; Chan, Catherine B.; Sauve, Yves] Univ Alberta, Dept Physiol, 7-55 Med Sci Bldg, Edmonton, AB T6G 2H7, Canada.
   [Chan, Catherine B.] Univ Alberta, Agr Food & Nutr Sci, Edmonton, AB, Canada.
   [Lemieux, Helene] Univ Alberta, Fac St Jean, Edmonton, AB, Canada.
C3 University of Alberta; University of Alberta; University of Alberta;
   University of Alberta
RP Sauvé, Y (corresponding author), Univ Alberta, Dept Physiol, 7-55 Med Sci Bldg, Edmonton, AB T6G 2H7, Canada.
EM ysauve@ualberta.ca
RI Chan, Catherine/C-1162-2011
OI Chan, Catherine/0000-0003-3882-0592; Huang, Hui/0000-0002-5823-8658;
   lemieux, Helene/0000-0002-8864-6062
FU Canadian Institutes of Health (CIHR) [MOP 125873]; Alberta Diabetes
   Institute; University of Alberta Faculty of Medicine and Dentistry 75th
   anniversary; China Scholarship Council
FX Supported by Canadian Institutes of Health (CIHR; MOP 125873) to YS and
   CBC; YS is an AHFMR Senior Scholar (200800242); JG received a
   scholarship from the Alberta Diabetes Institute. WHH received a
   scholarship from the University of Alberta Faculty of Medicine and
   Dentistry 75th anniversary. HH received a scholarship from the China
   Scholarship Council.
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NR 80
TC 27
Z9 28
U1 0
U2 3
PU ASSOC RESEARCH VISION OPHTHALMOLOGY INC
PI ROCKVILLE
PA 12300 TWINBROOK PARKWAY, ROCKVILLE, MD 20852-1606 USA
SN 0146-0404
EI 1552-5783
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD AUG
PY 2017
VL 58
IS 10
BP 3826
EP 3839
DI 10.1167/iovs.17-21929
PG 14
WC Ophthalmology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Ophthalmology
GA FH2AG
UT WOS:000410940400001
PM 28763556
OA gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Gozal, D
   Farré, R
   Nieto, FJ
AF Gozal, David
   Farre, Ramon
   Nieto, F. Javier
TI Obstructive sleep apnea and cancer: Epidemiologic links and theoretical
   biological constructs
SO SLEEP MEDICINE REVIEWS
LA English
DT Review
DE Sleep apnea; Sleep deprivation; Intermittent hypoxia; Cancer;
   Inflammation; Tumor-associated macrophages
ID EPITHELIAL-MESENCHYMAL TRANSITION; HYPOXIA-INDUCIBLE FACTORS; ROTATING
   SHIFT WORK; CHRONIC INTERMITTENT HYPOXIA; TUMOR-ASSOCIATED MACROPHAGES;
   BREAST-CANCER; BETA-BLOCKERS; MOUSE MODEL; METABOLIC SYNDROME; OXIDATIVE
   STRESS
AB Sleep disorders have emerged as highly prevalent conditions in the last 50-75 y. Along with improved understanding of such disorders, the realization that perturbations in sleep architecture and continuity may initiate, exacerbate or modulate the phenotypic expression of multiple diseases including cancer has gained increased attention. Furthermore, the intermittent hypoxia that is attendant to sleep disordered breathing, has recently been implicated in increased incidence and more adverse prognosis of cancer. The unifying conceptual framework linking these associations proposes that increased sympathetic activity and/or alterations in immune function, particularly affecting innate immune cellular populations, underlie the deleterious effects of sleep disorders on tumor biology. In this review, the epidemiological evidence linking disrupted sleep and intermittent hypoxia to oncological outcomes, and the potential biological underpinnings of such associations as illustrated by experimental murine models will be critically appraised. The overarching conclusion appears supportive in the formulation of an hypothetical framework, in which fragmented sleep and intermittent hypoxia may promote changes in multiple signalosomes and transcription factors that can not only initiate malignant transformation, but will also alter the tumor microenvironment, disrupt immunosurveillance, and thus hasten tumor proliferation and increase local and metastatic invasion. Future bench-based experimental studies as well as carefully conducted and controlled clinical epidemiological studies appear justified for further exploration of these hypotheses. (C) 2015 Elsevier Ltd. All rights reserved.
C1 [Gozal, David] Univ Chicago, Pritzker Sch Med, Dept Pediat, Div Biol Sci, Chicago, IL 60637 USA.
   [Farre, Ramon] Univ Barcelona IDIBAPS, Fac Med, Unitat Biofis & Bioengn, Barcelona, Spain.
   [Farre, Ramon] CIBER Enfermedades Resp, Madrid, Spain.
   [Nieto, F. Javier] Univ Wisconsin, Sch Med & Publ Hlth, Dept Populat Hlth Sci, Madison, WI USA.
C3 University of Chicago; University of Barcelona; Hospital Clinic de
   Barcelona; IDIBAPS; CIBER - Centro de Investigacion Biomedica en Red;
   CIBERES; University of Wisconsin System; University of Wisconsin Madison
RP Gozal, D (corresponding author), Univ Chicago, Pritzker Sch Med, Dept Pediat, 5721 S Maryland Ave,MC8000,K160, Chicago, IL 60637 USA.
EM dgozal@uchicago.edu
RI Gozal, David/ABH-3805-2020; Farre, Ramon/L-2664-2017
OI Farre, Ramon/0000-0002-9084-7824
FU National Institutes of Health [HL-65270, R01HL062252-11]; Herbert T.
   Abelson Endowed Chair in Pediatrics; Ministerio Espanol de Economia y
   Competitividad [PI14-00004]; University of Wisconsin Helfaer Endowed
   Chair of Public Health
FX DG is supported by National Institutes of Health grant HL-65270 and the
   Herbert T. Abelson Endowed Chair in Pediatrics. RF is supported by
   Ministerio Espanol de Economia y Competitividad, grant PI14-00004. FJN
   is supported in part by National Institutes of Health grant
   R01HL062252-11 and by the University of Wisconsin Helfaer Endowed Chair
   of Public Health.
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NR 159
TC 86
Z9 91
U1 1
U2 35
PU W B SAUNDERS CO LTD
PI LONDON
PA 32 JAMESTOWN RD, LONDON NW1 7BY, ENGLAND
SN 1087-0792
EI 1532-2955
J9 SLEEP MED REV
JI Sleep Med. Rev.
PD JUN
PY 2016
VL 27
BP 43
EP 55
DI 10.1016/j.smrv.2015.05.006
PG 13
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA DJ6ZF
UT WOS:000374361000007
PM 26447849
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Ozen, G
   Daci, A
   Norel, X
   Topal, G
AF Ozen, Gulsev
   Daci, Armond
   Norel, Xavier
   Topal, Gokce
TI Human perivascular adipose tissue dysfunction as a cause of vascular
   disease: Focus on vascular tone and wall remodeling
SO EUROPEAN JOURNAL OF PHARMACOLOGY
LA English
DT Review
DE Perivascular adipose tissue; Vascular tone; Vascular remodeling; Human;
   Obesity; Atherosclerosis
ID CORONARY-ARTERY-DISEASE; SAPHENOUS-VEIN GRAFT; INDUCED ENDOTHELIAL
   DYSFUNCTION; MUSCLE-CELL PROLIFERATION; RENIN-ANGIOTENSIN SYSTEM;
   NECROSIS-FACTOR-ALPHA; NITRIC-OXIDE; METABOLIC SYNDROME; INDUCED
   MIGRATION; OXIDATIVE STRESS
AB Obesity is one of the major risk factors for the development of cardiovascular diseases. It is characterized by excessive or abnormal accumulation of adipose tissue, including depots which surround the blood vessels named perivascular adipose tissue (PVAT). PVAT plays endocrine and paracrine roles by producing large numbers of metabolically vasoactive adipokines. The present review outlines our current understanding of the beneficial roles of PVAT in vascular tone and remodeling in healthy subjects supported by clinical studies, highlighting different factors or mechanisms that could mediate protective effects of PVAT on vascular function. Most studies in humans show that adiponectin is the best candidate for the advantageous effect of PVAT. However, in pathological conditions especially obesity-related cardiovascular diseases, the beneficial effects of PVAT on vascular functions are impaired and transform into detrimental roles. This change is defined as PVAT dysfunction. In the current review, the contribution of PVAT dysfunction to obesity-related cardiovascular diseases has been discussed with a focus on possible mechanisms including an imbalance between beneficial and detrimental adipokines (commonly described as decreased levels of adiponectin and increased levels of leptin or tumor necrosis factor-alpha (TNR alpha)), increased quantity of adipose tissue, inflammation, cell proliferation and endothelial dysfunction. Finally, novel pharmacotherapeutic targets for the treatment of cardiovascular and metabolic disorders are addressed. (C) 2015 Elsevier B.V. All rights reserved.
C1 [Ozen, Gulsev; Daci, Armond; Topal, Gokce] Istanbul Univ, Fac Pharm, Dept Pharmacol, TR-34116 Istanbul, Turkey.
   [Ozen, Gulsev; Norel, Xavier] CHU Xavier Bichat, INSERM, U1148, F-75018 Paris, France.
   [Norel, Xavier] Univ Paris 13, Sorbonne Paris Cite, UMR S1148, F-75018 Paris, France.
C3 Istanbul University; Assistance Publique Hopitaux Paris (APHP);
   Universite Paris Cite; Hopital Universitaire Bichat-Claude Bernard -
   APHP; Institut National de la Sante et de la Recherche Medicale
   (Inserm); Universite Paris 13; Universite Paris Cite; Assistance
   Publique Hopitaux Paris (APHP); Hopital Universitaire Bichat-Claude
   Bernard - APHP
RP Norel, X (corresponding author), CHU Xavier Bichat, INSERM, U1148, Lab Eicosanoids & Vasc Pharmacol,LVTS, 46 Rue Huchard, F-75018 Paris, France.
EM xavier.norel@inserm.fr
RI Daci, Armond/J-8529-2019; Topal, Gokce/AAD-7819-2020; Norel,
   Xavier/IVV-5676-2023; Ozen, Gulsev/AAD-4984-2020; Norel,
   Xavier/C-5978-2011
OI Norel, Xavier/0000-0003-0734-3359; Daci, Armond/0000-0003-1276-4561
FU Scientific and Technological Research Council of Turkey (TUBITAK)
   [BIDEB-2214]
FX We would like to thank Scientific and Technological Research Council of
   Turkey (TUBITAK) for postgraduate fellowship (BIDEB-2214) of Gulsev
   Ozen. We would like to thank Dr. Richard Bayles for editing of the
   manuscript.
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NR 131
TC 53
Z9 60
U1 0
U2 22
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0014-2999
EI 1879-0712
J9 EUR J PHARMACOL
JI Eur. J. Pharmacol.
PD NOV 5
PY 2015
VL 766
BP 16
EP 24
DI 10.1016/j.ejphar.2015.09.012
PG 9
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA CW2QF
UT WOS:000364836800003
PM 26424111
DA 2025-06-11
ER

PT J
AU Gui, J
   Rohrbach, A
   Borns, K
   Hillemanns, P
   Feng, L
   Hubel, CA
   von Versen-Höynck, F
AF Gui, J.
   Rohrbach, A.
   Borns, K.
   Hillemanns, P.
   Feng, L.
   Hubel, C. A.
   von Versen-Hoeynck, F.
TI Vitamin D rescues dysfunction of fetal endothelial colony forming cells
   from individuals with gestational diabetes
SO PLACENTA
LA English
DT Article
DE Gestational diabetes mellitus; Endothelial progenitor cells;
   Angiogenesis; Migration
ID PROGENITOR CELLS; INSULIN-RESISTANCE; D SUPPLEMENTATION;
   CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; OXIDATIVE STRESS;
   CLINICAL-TRIAL; DOUBLE-BLIND; D DEFICIENCY; PREGNANCY
AB Introduction: Gestational diabetes (GDM) is associated with long-term cardiovascular and metabolic diseases in offspring. However, the mechanisms are not well understood. We explored whether fetal exposure to a diabetic environment is associated with fetal endothelial progenitor cell dysfunction, and whether vitamin D can reverse the impairment.
   Methods: Nineteen women with uncomplicated pregnancies and 18 women with GDM were recruited before delivery. Time to first appearance of endothelial colony forming cell (ECFC) colonies and number of ECFC colonies formed from culture of cord peripheral blood mononuclear cells were determined. Angiogenesis-related functions of ECFCs in vitro were tested in the presence or absence of vitamin D.
   Results: Fetal ECFCs from GDM pregnancies formed fewer colonies in culture (P = 0.04) and displayed reduced proliferation (P = 0.02), migration (P = 0.04) and tubule formation (P = 0.03) compared to uncomplicated pregnancies. Fetal ECFCs exposed to hyperglycemia in vitro exhibited less migration (P < 0.05) and less tubule formation (P < 0.05) than normoglycemic control. Vitamin D significantly improved the dysfunction of fetal ECFCs from pregnancies complicated by GDM or after exposure of healthy ECFCs to hyperglycemia.
   Discussion: Fetal ECFCs from GDM pregnancies or ECFCs exposed to hyperglycemia in vitro exhibit reduced quantity and impaired angiogenesis-related functions. Vitamin D significantly rescues these functions. These findings may have implications for vascular function of infants exposed to a diabetic intrauterine environment. (C) 2015 Elsevier Ltd. All rights reserved.
C1 [Gui, J.; Rohrbach, A.; Borns, K.; Hillemanns, P.; von Versen-Hoeynck, F.] Hannover Med Sch, Dept Obstet & Gynecol, D-30625 Hannover, Germany.
   [Gui, J.; Feng, L.] Huazhong Univ Sci & Technol, Dept Obstet & Gynecol, Tongji Hosp, Tongji Med Coll, Wuhan, Hubei, Peoples R China.
   [Hubel, C. A.] Univ Pittsburgh, Magee Womens Res Inst, Pittsburgh, PA USA.
   [Hubel, C. A.] Univ Pittsburgh, Dept Obstet Gynecol & Reprod Sci, Pittsburgh, PA USA.
C3 Hannover Medical School; Huazhong University of Science & Technology;
   Pennsylvania Commonwealth System of Higher Education (PCSHE); University
   of Pittsburgh; Magee-Womens Research Institute; Pennsylvania
   Commonwealth System of Higher Education (PCSHE); University of
   Pittsburgh
RP von Versen-Höynck, F (corresponding author), Hannover Med Sch, Dept Obstet & Gynecol, Carl Neuberg Str 1, D-30625 Hannover, Germany.
EM 514325204@qq.com; Rohrbach.anne@mh-hannover.de;
   Borns.katja@mh-hannover.de; hillemanns.peter@mh-hannover.de;
   fltj007@163.com; chubel@mwri.magee.edu;
   vonversen-hoeynck.frauke@mh-hannover.de
RI von Versen-Höynck, Frauke/H-3719-2019; von Versen-Hoynck,
   Frauke/P-7160-2017
OI von Versen-Hoynck, Frauke/0000-0002-1924-5695
FU German Diabetes Association (Deutsche Diabetes Gesellschaft); Chinese
   Scholarship Council
FX We are grateful to all study participants and the staff of the Division
   of Obstetrics at Hannover Medical School for invaluable assistance in
   obtaining samples. The study was supported by funding from the German
   Diabetes Association (Deutsche Diabetes Gesellschaft) and a scholarship
   from the Chinese Scholarship Council for JG.
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NR 48
TC 32
Z9 33
U1 0
U2 12
PU W B SAUNDERS CO LTD
PI LONDON
PA 32 JAMESTOWN RD, LONDON NW1 7BY, ENGLAND
SN 0143-4004
EI 1532-3102
J9 PLACENTA
JI Placenta
PD APR
PY 2015
VL 36
IS 4
BP 410
EP 418
DI 10.1016/j.placenta.2015.01.195
PG 9
WC Developmental Biology; Obstetrics & Gynecology; Reproductive Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Developmental Biology; Obstetrics & Gynecology; Reproductive Biology
GA CE4JI
UT WOS:000351796500012
PM 25684656
DA 2025-06-11
ER

PT J
AU Buettner, R
   Ascher, M
   Gäbele, E
   Hellerbrand, C
   Kob, R
   Bertsch, T
   Bollheimer, LC
AF Buettner, R.
   Ascher, M.
   Gaebele, E.
   Hellerbrand, C.
   Kob, R.
   Bertsch, T.
   Bollheimer, L. C.
TI Olive Oil Attenuates the Cholesterol-induced Development of Nonalcoholic
   Steatohepatitis Despite Increased Insulin Resistance in a Rodent Model
SO HORMONE AND METABOLIC RESEARCH
LA English
DT Article
DE nonalcoholic steatohepatitis; atherogenic diet; insulin resistance
ID FATTY LIVER-DISEASE; ENDOPLASMIC-RETICULUM STRESS; DIETARY-CHOLESTEROL;
   LIPID-PEROXIDATION; HEPATIC STEATOSIS; ATHEROGENIC DIET; VIRGIN OLIVE;
   ACIDS; MICE; EXPRESSION
AB It is indefinite whether nonalcoholic steatohepatitis (NASH) results as by-product from general metabolic perturbations and adipokine dysregulations or whether defined dietary factors also play a pathogenetic role. Here, we examine the effects of a modification of dietary lipids in a NASH inducing diet on metabolic changes as well as hepatic steatosis, inflammation, and fibrosis in rats. Male Wistar rats were fed with variations of the atherogenic diet (AD), which induces pathophysiological changes resembling human NASH. Dietary variants (AD without cholesterol, cholate, or choline; change of neutral fat to olive oil or coconut oil) were fed for 8 weeks. Insulin resistance, adipokine profile, liver histology, and lipid content as well as expression of proinflammatory and profibrogenic genes were examined. AD led to clear signs of hepatic steatosis and inflammation together with an increase in TNF and collagen type 1 expression. AD without cholesterol showed markedly less liver damage without changes of insulin action and adipokine profile. AD with olive oil and AD without cholate clearly attenuated hepatic inflammation, whereas fat deposition and features of the metabolic syndrome were increased in these animals. Insulin resistance and hepatic fat deposition per se do not cause significant hepatic inflammation in this rodent model. However, dietary cholesterol is an important causal agent for the development of NASH. Olive oil plays a protective role in this respect, which might be due to the high content of monounsaturated fatty acids.
C1 [Buettner, R.; Ascher, M.; Gaebele, E.; Hellerbrand, C.] Univ Med Ctr Regensburg, Dept Internal Med 1, D-93042 Regensburg, Germany.
   [Kob, R.; Bollheimer, L. C.] Univ Erlangen Nurnberg, Inst Biomed Aging, Nurnberg, Germany.
   [Bertsch, T.] Nurnberg Hosp, Lab Med & Transfus Med, Inst Clin Chem, Nurnberg, Germany.
   [Bertsch, T.] Univ Hosp Mannheim, Inst Clin Chem, Mannheim, Germany.
C3 University of Regensburg; University of Erlangen Nuremberg; Ruprecht
   Karls University Heidelberg
RP Buettner, R (corresponding author), Univ Med Ctr Regensburg, Dept Internal Med 1, Franz Josef Strauss Allee 11, D-93042 Regensburg, Germany.
EM roland.buettner@ukr.de
RI Bollheimer, Cornelius/AFL-6643-2022; Kob, Robert/AAI-5913-2020
OI Kob, Robert/0000-0002-0406-092X
FU University Medical Center of Regensburg's ReForM C grant program
FX The study was supported by the University Medical Center of Regensburg's
   ReForM C grant program.
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NR 38
TC 16
Z9 18
U1 0
U2 24
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0018-5043
EI 1439-4286
J9 HORM METAB RES
JI Horm. Metab. Res.
PD OCT
PY 2013
VL 45
IS 11
BP 795
EP 801
DI 10.1055/s-0033-1353209
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 234ZV
UT WOS:000325684600004
PM 23996518
OA Bronze
DA 2025-06-11
ER

PT J
AU Hirsch, HA
   Iliopoulos, D
   Struhl, K
AF Hirsch, Heather A.
   Iliopoulos, Dimitrios
   Struhl, Kevin
TI Metformin inhibits the inflammatory response associated with cellular
   transformation and cancer stem cell growth
SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF
   AMERICA
LA English
DT Article
DE cancer treatment; inflammation; cancer prevention
ID BREAST-CANCER; METABOLIC SYNDROME; RESPIRATORY-CHAIN; DIABETIC-PATIENTS;
   PROTEIN-KINASE; CYCLE ARREST; ACTIVATION; AMPK; CHEMOTHERAPY; DECREASES
AB Metformin, the first-line drug for treating diabetes, inhibits cellular transformation and selectively kills cancer stem cells in breast cancer cell lines. In a Src-inducible model of cellular transformation, metformin inhibits the earliest known step in the process, activation of the inflammatory transcription factor NF-kappa B. Metformin strongly delays cellular transformation in a manner similar to that occurring upon a weaker inflammatory stimulus. Conversely, inhibition of transformation does not occur if metformin is added after the initial inflammatory stimulus. The antitransformation effect of metformin can be bypassed by overexpression of Lin28B or IL1 beta, downstream targets of NF-kappa B. Metformin preferentially inhibits nuclear translocation of NF-kappa B and phosphorylation of STAT3 in cancer stem cells compared with non-stem cancer cells in the same population. The ability of metformin to block tumor growth and prolong remission in xenografts in combination with doxorubicin is associated with decreased function of the inflammatory feedback loop. Lastly, metformin-based combinatorial therapy is effective in xenografts involving inflammatory prostate and melanoma cell lines, whereas it is ineffective in noninflammatory cell lines from these lineages. Taken together, our observations suggest that metformin inhibits a signal transduction pathway that results in an inflammatory response. As metformin alters energy metabolism in diabetics, we speculate that metformin may block a metabolic stress response that stimulates the inflammatory pathway associated with a wide variety of cancers.
C1 [Hirsch, Heather A.; Iliopoulos, Dimitrios; Struhl, Kevin] Harvard Univ, Sch Med, Dept Biol Chem & Mol Pharmacol, Boston, MA 02115 USA.
C3 Harvard University; Harvard Medical School
RP Struhl, K (corresponding author), Harvard Univ, Sch Med, Dept Biol Chem & Mol Pharmacol, Boston, MA 02115 USA.
EM kevin@hms.harvard.edu
RI Iliopoulos, Dimitrios/AAE-9106-2019
FU National Institutes of Health [CA 107486]
FX We thank Philip N. Tsichlis for providing laboratory access and
   materials needed for the xenograft experiments. This work was supported
   by grants (to K. S.) from the National Institutes of Health (CA 107486).
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NR 34
TC 363
Z9 386
U1 1
U2 105
PU NATL ACAD SCIENCES
PI WASHINGTON
PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA
SN 0027-8424
J9 P NATL ACAD SCI USA
JI Proc. Natl. Acad. Sci. U. S. A.
PD JAN 15
PY 2013
VL 110
IS 3
BP 972
EP 977
DI 10.1073/pnas.1221055110
PG 6
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 075TI
UT WOS:000313909100044
PM 23277563
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Dandona, P
   Chaudhuri, A
   Ghanim, H
   Mohanty, P
AF Dandona, Paresh
   Chaudhuri, Ajay
   Ghanim, Husam
   Mohanty, Priya
TI Use of insulin to improve glycemic control in diabetes mellitus
SO CARDIOVASCULAR DRUGS AND THERAPY
LA English
DT Review
DE diabetes mellitus; glycemic control; insulin; inflammation
ID ACUTE MYOCARDIAL-INFARCTION; C-REACTIVE PROTEIN; NECROSIS-FACTOR-ALPHA;
   PLASMINOGEN-ACTIVATOR INHIBITOR; SYSTEMIC INFLAMMATORY RESPONSE;
   CIRCULATING MONONUCLEAR-CELLS; NITRIC-OXIDE SYNTHASE; PLASMA TISSUE
   FACTOR; FACTOR-KAPPA-B; METABOLIC SYNDROME
AB Background The restoration of normoglycemia ensures the control of diabetic symptoms and reduction in microangiopathic complications in type 1 and type 2 diabetes. However, there is no conclusive evidence that intensive glycemic control alone will prevent macrovascular disease, the commonest cause of morbidity and mortality in type 2 diabetes. As atherosclerosis is an inflammatory condition, it is relevant that the two common insulin resistant states of obesity and type 2 diabetes have significant inflammatory processes, which promote atherosclerosis. It is also relevant that glucose has been shown to have profound effects on the endothelial cell, the leukocyte and the platelet. These effects include the induction of acute oxidative and inflammatory stress and a prothrombotic and pro-apoptotic effect following glucose intake. In contrast insulin has been shown to exert several biological effects at physiologically relevant concentrations, in relation to the endothelial cell, the platelet and leucocyte function, which may be cardioprotective and potentially anti-atherosclerotic.
   Conclusion These findings are of great interest as it is possible that the prevention of macrovascular complications in type 2 diabetes may require the use of those glucose lowering drugs which have additional anti-inflammatory effects in addition to the control of comorbid conditions (hypertension and dyslipidemia) associated with this disease. Results of future clinical trials are awaited to confirm the benefits of this approach in the primary and secondary prevention of macrovascular complications in type 2 diabetes.
C1 [Dandona, Paresh] Diabet Endocrinol Ctr WNY, Buffalo, NY 14209 USA.
   [Dandona, Paresh; Chaudhuri, Ajay; Ghanim, Husam; Mohanty, Priya] SUNY Buffalo, Div Endocrinol Diabet & Metab, Buffalo, NY 14209 USA.
   [Dandona, Paresh] Kaleida Hlth, Buffalo, NY 14209 USA.
C3 State University of New York (SUNY) System; University at Buffalo, SUNY;
   Kaleida Health
RP Dandona, P (corresponding author), Diabet Endocrinol Ctr WNY, 3 Gates Circle, Buffalo, NY 14209 USA.
EM pdandona@kaleidahealth.org
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NR 114
TC 11
Z9 11
U1 0
U2 5
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0920-3206
EI 1573-7241
J9 CARDIOVASC DRUG THER
JI Cardiovasc. Drugs Ther.
PD JUN
PY 2008
VL 22
IS 3
BP 241
EP 251
DI 10.1007/s10557-008-6101-3
PG 11
WC Cardiac & Cardiovascular Systems; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Pharmacology & Pharmacy
GA 330CP
UT WOS:000257917400013
PM 18347965
DA 2025-06-11
ER

PT J
AU Ratziu, V
   Munteanu, M
   Charlotte, F
   Bonyhay, L
   Poynard, T
AF Ratziu, V
   Munteanu, M
   Charlotte, F
   Bonyhay, L
   Poynard, T
CA LIDO Study Grp
TI Fibrogenic impact of high serum glucose in chro nic hepatitis C
SO JOURNAL OF HEPATOLOGY
LA English
DT Article
DE non-alcoholic steatohepatitis (NASH); hepatitis C; obesity; diabetes;
   liver fibrosis
ID LIVER FIBROSIS PROGRESSION; INDUCED INSULIN-RESISTANCE; GLYCATION
   END-PRODUCTS; DIABETES-MELLITUS; RISK-FACTORS; GENE-EXPRESSION;
   VIRUS-INFECTION; OXIDANT STRESS; PATHOGENESIS; PROTEIN
AB Background/Aims: There is considerable variability in the rate of fibrosis progression in patients with chronic hepatitis C, most of which is related to factors so far unknown. We tested the hypothesis that high serum glucose and overweight might contribute to this variability.
   Methods: Seven hundred and ten patients with chronic hepatitis C with a known duration of infection and no hepatitis B virus or human immunodeficiency virus coinfection were studied. Significant fibrosis was defined as bridging fibrosis including cirrhosis. Variables were tested for their association with significant fibrosis.
   Results: In univariate analyses both serum glucose and body mass index were associated with fibrosis. In multivariate analyses, age at infection, duration of infection, serum glucose and daily alcohol intake but not body mass index were independently associated with significant fibrosis. Patients with high serum glucose had been contaminated at an older age and had features of the metabolic syndrome, including steatosis more frequently, as well as faster fibrosis progression rates. High serum glucose was associated with intermediate and advanced, but not with early, fibrosis stages. A high serum glucose was associated with a higher relative risk for significant fibrosis than overweight.
   Conclusions: High serum glucose, is an independent co-factor of fibrosis in chronic hepatitis C with a higher profibrogenic impact than overweight. (C) 2003 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
C1 Hop La Pitie Salpetriere, Serv Hepatogastroenterol, F-75013 Paris, France.
   Hop La Pitie Salpetriere, CNRS ESA 8067, F-75013 Paris, France.
   Hop La Pitie Salpetriere, Serv Anat Pathol, F-75013 Paris, France.
C3 Assistance Publique Hopitaux Paris (APHP); Hopital Universitaire
   Pitie-Salpetriere - APHP; Sorbonne Universite; Assistance Publique
   Hopitaux Paris (APHP); Hopital Universitaire Pitie-Salpetriere - APHP;
   Sorbonne Universite; Sorbonne Universite; Assistance Publique Hopitaux
   Paris (APHP); Hopital Universitaire Pitie-Salpetriere - APHP
RP Hop La Pitie Salpetriere, Serv Hepatogastroenterol, 47-83 Bd Hop, F-75013 Paris, France.
EM vratziu@teaser.fr
RI Poynard, Thierry/C-1355-2010; Ratziu, Vlad/AFL-9740-2022
OI Charlotte, Frederic/0000-0003-2803-6606; Poynard,
   Thierry/0000-0002-2050-640X
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NR 36
TC 127
Z9 135
U1 0
U2 6
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0168-8278
EI 1600-0641
J9 J HEPATOL
JI J. Hepatol.
PD DEC
PY 2003
VL 39
IS 6
BP 1049
EP 1055
DI 10.1016/S0168-8278(03)00456-2
PG 7
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 753HE
UT WOS:000187225300024
PM 14642625
DA 2025-06-11
ER

PT J
AU Kettunen, S
   Suoranta, T
   Beikverdi, S
   Heikkilä, M
   Slita, A
   Räty, I
   Ylä-Herttuala, E
   Öörni, K
   Ruotsalainen, AK
   Ylä-Herttuala, S
AF Kettunen, Sanna
   Suoranta, Tuisku
   Beikverdi, Sadegh
   Heikkila, Minja
   Slita, Anna
   Raty, Iida
   Yla-Herttuala, Elias
   Oorni, Katariina
   Ruotsalainen, Anna-Kaisa
   Yla-Herttuala, Seppo
TI Deletion of the Murine Ortholog of the Human 9p21.3 Locus Leads to
   Insulin Resistance and Obesity in Hypercholesterolemic Mice
SO CELLS
LA English
DT Article
DE lncRNA; 9p21.3; ANRIL; Ak148321; insulin resistance; obesity; Cdkn2a/b;
   Chr4(Delta 70/Delta 70)
ID GENOME-WIDE ASSOCIATION; CORONARY-ARTERY-DISEASE; ADIPOSE-TISSUE;
   OXIDATIVE-PHOSPHORYLATION; SIRT1; RISK; ATHEROSCLEROSIS; EXPRESSION;
   ANRIL; SNPS
AB The 9p21.3 genomic locus is a hot spot for disease-associated single-nucleotide polymorphisms (SNPs), and its strongest associations are with coronary artery disease (CAD). The disease-associated SNPs are located within the sequence of a long noncoding RNA ANRIL, which potentially contributes to atherogenesis by regulating vascular cell stress and proliferation, but also affects pancreatic beta-cell proliferation. Altered expression of a neighboring gene, CDKN2B, has been also recognized to correlate with obesity and hepatic steatosis in people carrying the risk SNPs. In the present study, we investigated the impact of 9p21.3 on obesity accompanied by hyperlipidemia in mice carrying a deletion of the murine ortholog for the 9p21.3 (Chr4(Delta 70/Delta 70)) risk locus in hyperlipidemic Ldlr(-/-)ApoB(100/100) background. The Chr4(Delta 70/Delta 70) mice showed decreased mRNA expression of insulin receptors in white adipose tissue already at a young age, which developed into insulin resistance and obesity by aging. In addition, the Sirt1-Ppargc1a-Ucp2 pathway was downregulated together with the expression of Cdkn2b, specifically in the white adipose tissue in Chr4(Delta 70/Delta 70) mice. These results suggest that the 9p21.3 locus, ANRIL lncRNA, and their murine orthologues may regulate the key energy metabolism pathways in a white adipose tissue-specific manner in the presence of hypercholesterolemia, thus contributing to the pathogenesis of metabolic syndrome.
C1 [Kettunen, Sanna; Suoranta, Tuisku; Beikverdi, Sadegh; Heikkila, Minja; Slita, Anna; Raty, Iida; Yla-Herttuala, Elias; Ruotsalainen, Anna-Kaisa; Yla-Herttuala, Seppo] Univ Eastern Finland, AI Virtanen Inst, Kuopio 70210, Finland.
   [Yla-Herttuala, Elias] Kuopio Univ Hosp, Imaging Ctr, Kuopio 70200, Finland.
   [Oorni, Katariina] Wihuri Res Inst, Helsinki 00290, Finland.
C3 University of Eastern Finland; Kuopio University Hospital; University of
   Eastern Finland; University of Eastern Finland Hospital; Wihuri Research
   Institute
RP Ruotsalainen, AK (corresponding author), Univ Eastern Finland, AI Virtanen Inst, Kuopio 70210, Finland.
EM sanna.kettunen@uef.fi; tuisku.suoranta@uef.fi;
   sadegh.beikverdi@helsinki.fi; minja.heikkila@uef.fi; anna.slita@uef.fi;
   iida.raty@uef.fi; elias.yla-herttuala@uef.fi; kati.oorni@wri.fi;
   anna-kaisa.ruotsalainen@uef.fi; seppo.ylaherttuala@uef.fi
RI Kettunen, Sanna/HRB-3512-2023; Suoranta, Tuisku/AFM-6264-2022;
   Yla-Herttuala, Elias/AAU-3009-2021; Oorni, Katariina/G-2484-2011
OI Oorni, Katariina/0000-0002-9525-0250; Kettunen,
   Sanna/0000-0001-6096-2402; Suoranta, Tuisku/0000-0003-0140-320X;
   Yla-Herttuala, Elias/0000-0003-3268-7305; Ruotsalainen,
   Anna-Kaisa/0000-0002-8512-3768
FU Aarne Koskelo Foundation
FX Maija Atuegwu is acknowledged for her excellent assistance in performing
   the plasma lipid analysis for this study. The Kuopio Biomedical imaging
   unit is acknowledged for their MRI services. We also want to thank Uma
   Thanigai Arasu for assistance with cell culture, and the personnel of
   the Laboratory Animal Center for animal care. The graphical abstract and
   Figure 1A were created at BioRender.com.
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NR 55
TC 3
Z9 3
U1 0
U2 0
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2073-4409
J9 CELLS-BASEL
JI Cells
PD JUN
PY 2024
VL 13
IS 11
AR 983
DI 10.3390/cells13110983
PG 20
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA UQ4P4
UT WOS:001249513800001
PM 38891115
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Song, HB
   Zhang, XH
   Wang, J
   Wu, YL
   Xiong, TM
   Shen, JQ
   Lin, RY
   Xiao, TF
   Lin, WM
AF Song, Hongbing
   Zhang, Xiaohan
   Wang, Jing
   Wu, Yanling
   Xiong, Taimin
   Shen, Jieqiong
   Lin, Ruiyi
   Xiao, Tianfang
   Lin, Weimin
TI The regulatory role of adipocyte mitochondrial homeostasis in
   metabolism-related diseases
SO FRONTIERS IN PHYSIOLOGY
LA English
DT Review
DE adipocyte; adipose tissue; mitochondria; obesity; metabolic syndrome
ID MESENCHYMAL STEM-CELLS; SUBCUTANEOUS ADIPOSE-TISSUE; BODY-MASS INDEX;
   ENDOPLASMIC-RETICULUM; STROMAL CELLS; PERILIPIN 5; ADIPONECTIN
   SYNTHESIS; DYSFUNCTION TRIGGERS; INSULIN SENSITIVITY; OXIDATIVE STRESS
AB Adipose tissue is the most important energy storage organ in the body, maintaining its normal energy metabolism function and playing a vital role in keeping the energy balance of the body to avoid the harm caused by obesity and a series of related diseases resulting from abnormal energy metabolism. The dysfunction of adipose tissue is closely related to the occurrence of diseases related to obesity metabolism. Among various organelles, mitochondria are the main site of energy metabolism, and mitochondria maintain their quality through autophagy, biogenesis, transfer, and dynamics, which play an important role in maintaining metabolic homeostasis of adipocytes. On the other hand, mitochondria have mitochondrial genomes which are vulnerable to damage due to the lack of protective structures and their proximity to sites of reactive oxygen species generation, thus affecting mitochondrial function. Notably, mitochondria are closely related to other organelles in adipocytes, such as lipid droplets and the endoplasmic reticulum, which enhances the function of mitochondria and other organelles and regulates energy metabolism processes, thus reducing the occurrence of obesity-related diseases. This article introduces the structure and quality control of mitochondria in adipocytes and their interactions with other organelles in adipocytes, aiming to provide a new perspective on the regulation of mitochondrial homeostasis in adipocytes on the occurrence of obesity-related diseases, and to provide theoretical reference for further revealing the molecular mechanism of mitochondrial homeostasis in adipocytes on the occurrence of obesity-related diseases.
C1 [Song, Hongbing; Zhang, Xiaohan; Wang, Jing; Wu, Yanling; Xiong, Taimin; Shen, Jieqiong; Lin, Ruiyi; Xiao, Tianfang; Lin, Weimin] Fujian Agr & Forestry Univ, Coll Anim Sci, Coll Bee Sci, Fuzhou, Fujian, Peoples R China.
C3 Fujian Agriculture & Forestry University
RP Xiao, TF; Lin, WM (corresponding author), Fujian Agr & Forestry Univ, Coll Anim Sci, Coll Bee Sci, Fuzhou, Fujian, Peoples R China.
EM weiminlin@fafu.edu.cn; tfxiao@163.com
RI lin, weimin/AAV-2797-2020
FU The author(s) declare financial support was received for the research,
   authorship, and/or publication of this article. This project was
   supported by the Natural Science Foundation of Fujian Province
   (2023J01446 and 2020J01537); the Fujian Province Young an [2023J01446,
   2020J01537]; Natural Science Foundation of Fujian Province [JAT220059];
   Fujian Province Young and Middle-Aged Teacher Education Research Project
   [KFb22064XA]; Special Fund for Science and Technology Innovation of
   Fujian Agriculture and Forestry University
FX The author(s) declare financial support was received for the research,
   authorship, and/or publication of this article. This project was
   supported by the Natural Science Foundation of Fujian Province
   (2023J01446 and 2020J01537); the Fujian Province Young and Middle-Aged
   Teacher Education Research Project (JAT220059); and Special Fund for
   Science and Technology Innovation of Fujian Agriculture and Forestry
   University (KFb22064XA).
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NR 167
TC 11
Z9 11
U1 1
U2 15
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1664-042X
J9 FRONT PHYSIOL
JI Front. Physiol.
PD OCT 18
PY 2023
VL 14
AR 1261204
DI 10.3389/fphys.2023.1261204
PG 14
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA W4CQ0
UT WOS:001091124800001
PM 37920803
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Anala, AD
   Saifudeen, ISH
   Ibrahim, M
   Nanda, M
   Naaz, N
   Atkin, SL
AF Anala, Alekya Devi
   Saifudeen, Insiya Sajjad Hussain
   Ibrahim, Maryam
   Nanda, Moksha
   Naaz, Nida
   Atkin, Stephen L.
TI The Potential Utility of Tirzepatide for the Management of Polycystic
   Ovary Syndrome
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Review
DE polycystic ovary syndrome; insulin resistance; obesity; metabolic
   dysfunction; tirzepatide; glucagon-like peptide receptor agonist; weight
   loss; hyperandrogenism
ID GLUCAGON-LIKE PEPTIDE-1; GLP-1 RECEPTOR AGONIST; GASTRIC-INHIBITORY
   POLYPEPTIDE; TYPE-2 DIABETES-MELLITUS; THYROID C-CELLS;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; MACROPHAGE INFILTRATION; BARIATRIC
   SURGERY; ADVERSE EVENTS
AB Polycystic ovary syndrome (PCOS) is the most prevalent endocrinopathy in women of reproductive age. The metabolic dysfunction associated with PCOS increases the probability of developing type 2 diabetes (T2D), endometrial cancer, and cardiovascular disease. Research has shown that the metabolic features of PCOS may be improved by weight loss following treatment with glucagon-like peptide-1 receptor (GLP-1R) agonists. Tirzepatide is a dual GLP-GIP (gastric inhibitory polypeptide) receptor agonist that shares a very similar mechanism of action with GLP-1R agonists, and it is hypothesized that it may be a potential contender in the treatment of PCOS. The success of GLP-1R agonists is usually hindered by their adverse gastrointestinal effects, leading to reduced compliance. The mechanism of action of Tirzepatide partly addresses this issue, as its dual receptor affinity may reduce the intensity of gastrointestinal symptoms. Tirzepatide has been licensed for the treatment of type 2 diabetes and given the metabolic issues and obesity that accompanies PCOS, it may be of value in its management for those PCOS patients who are obese with metabolic syndrome, although it may not benefit those who are of normal weight. This study reviews the current therapies for the treatment of PCOS and evaluates the potential use of Tirzepatide to address the symptoms of PCOS, including reproductive dysfunction, obesity, and insulin resistance.
C1 [Anala, Alekya Devi; Saifudeen, Insiya Sajjad Hussain; Ibrahim, Maryam; Nanda, Moksha; Naaz, Nida; Atkin, Stephen L.] Royal Coll Surg Ireland Bahrain, Sch Med, Adliya 15503, Bahrain.
C3 Royal College of Surgeons - Ireland; Royal College of Surgeons in
   Ireland - Medical University of Bahrain
RP Atkin, SL (corresponding author), Royal Coll Surg Ireland Bahrain, Sch Med, Adliya 15503, Bahrain.
EM 20203265@rcsi-mub.com; 21200444@rcsi-mub.com; 21200503@rcsi-mub.com;
   21202073@rcsi-mub.com; 20200884@rcsi-mub.com; satkin@rcsi.com
RI Atkin, stephen/ABE-7047-2020; Atkin, Stephen/D-7400-2014
OI Atkin, Stephen/0000-0002-5887-7257
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NR 138
TC 4
Z9 5
U1 2
U2 13
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD JUL
PY 2023
VL 12
IS 14
AR 4575
DI 10.3390/jcm12144575
PG 19
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA N3DU5
UT WOS:001035868300001
PM 37510690
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Kamel, AM
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AF Kamel, Ahmed Mohamed
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TI Therapeutic Potential of Artichoke in the Treatment of Fatty Liver: A
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SO JOURNAL OF MEDICINAL FOOD
LA English
DT Review
DE artichoke leaf extract; meta-analysis; nonalcoholic fatty liver;
   systematic review
ID CYNARA-SCOLYMUS L.; LEAF EXTRACT; CARDIOVASCULAR-DISEASE; METABOLIC
   SYNDROME; OXIDATIVE STRESS; MS; PARAMETERS; PEOPLE; LEAVES; RISK
AB Nonalcoholic fatty liver disease (NAFLD) is a major chronic liver disease that can lead to liver cirrhosis, liver cancer, and death. Artichoke leaf extract (ALE) is well known in folk medicine for its hepatoprotective effect. Till recent times, no sufficient data from randomized clinical trials (RCTs) exist to support such use. This meta-analysis summarizes evidence from recent RCTs that evaluated ALE in NAFLD patients. Electronic databases were searched for RCTs that used ALE in NAFLD patients. The random-effects model was used to pool effect sizes (standardized change score). Data synthesis from five RCTs (333 patients) showed that ALE resulted in a significant reduction in alanine aminotransferase (standardized mean difference [SMD]: 1.1; 95% confidence interval [CI], 0.79-1.73; P < .001) and aspartate aminotransferase levels (SMD: 1.01; 95% CI, 0.52-1.51; P < .001) compared with the control group. ALE also resulted in a significant reduction in total cholesterol (SMD: 0.98; 95% CI, 0.53-1.43; P = .004), low-density lipoprotein (SMD: 0.96; 95% CI, 0.3-1.62; P < .001) and triglycerides (SMD: 0.95; 95% CI, 0.58-1.32; P < .001). The current review provides evidence from RCTs to support the use of ALE as a hepatoprotective agent in NAFLD patients. The study was registered on the PROSPERO database with the Registration No. CRD42020182502 (https://www.crd.york.ac.uk/prospero).
C1 [Kamel, Ahmed Mohamed] Cairo Univ, Fac Pharm, Dept Clin Pharm, Cairo, Egypt.
   [Farag, Mohamed Ali] Cairo Univ, Fac Pharm, Dept Pharmacognosy, Cairo, Egypt.
   [Kamel, Ahmed Mohamed] Cairo Univ, Fac Pharm, Dept Clin Phar macy, Cairo 11562, Egypt.
   [Farag, Mohamed Ali] Cairo Univ, Fac Pharm, Dept Pharmacognosy, Cairo 11562, Egypt.
C3 Egyptian Knowledge Bank (EKB); Cairo University; Egyptian Knowledge Bank
   (EKB); Cairo University; Egyptian Knowledge Bank (EKB); Cairo
   University; Egyptian Knowledge Bank (EKB); Cairo University
RP Kamel, AM (corresponding author), Cairo Univ, Fac Pharm, Dept Clin Phar macy, Cairo 11562, Egypt.; Farag, MA (corresponding author), Cairo Univ, Fac Pharm, Dept Pharmacognosy, Cairo 11562, Egypt.
EM ahmedm.kamel@pharma.cu.edu.eg; mohamed.farag@pharma.cu.edu.eg
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NR 57
TC 11
Z9 11
U1 0
U2 19
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1096-620X
EI 1557-7600
J9 J MED FOOD
JI J. Med. Food
PD OCT 1
PY 2022
VL 25
IS 10
BP 931
EP 942
DI 10.1089/jmf.2022.0025
EA JUN 2022
PG 12
WC Chemistry, Medicinal; Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Food Science & Technology; Nutrition &
   Dietetics
GA 5N9PX
UT WOS:000817646300001
PM 35763310
DA 2025-06-11
ER

PT J
AU Huang, C
   Rosencrans, RF
   Bugescu, R
   Vieira, CP
   Hu, P
   Adu-Agyeiwaah, Y
   Gamble, KL
   Longhini, ALF
   Fuller, PM
   Leinninger, GM
   Grant, MB
AF Huang, Chao
   Rosencrans, Robert F.
   Bugescu, Raluca
   Vieira, Cristiano P.
   Hu, Ping
   Adu-Agyeiwaah, Yvonne
   Gamble, Karen L.
   Longhini, Ana Leda F.
   Fuller, Patrick M.
   Leinninger, Gina M.
   Grant, Maria B.
TI Depleting hypothalamic somatostatinergic neurons recapitulates diabetic
   phenotypes in mouse brain, bone marrow, adipose and retina
SO DIABETOLOGIA
LA English
DT Article
DE Diabetes; Electroretinogram; Hypothalamus; Monocytosis; Neuroimmunology;
   Retina; Somatostatin
ID SYMPATHETIC NEURONS; MICE; ASTROCYTES; ACTIVATION; MICROGLIA; RELEASE;
   OBESITY; STRESS; MODEL
AB Aims/hypothesis Hypothalamic inflammation and sympathetic nervous system hyperactivity are hallmark features of the metabolic syndrome and type 2 diabetes. Hypothalamic inflammation may aggravate metabolic and immunological pathologies due to extensive sympathetic activation of peripheral tissues. Loss of somatostatinergic (SST) neurons may contribute to enhanced hypothalamic inflammation. Methods The present data show that leptin receptor-deficient (db/db) mice exhibit reduced hypothalamic SST neurons, particularly in the periventricular nucleus. We model this finding, using adeno-associated virus delivery of diphtheria toxin subunit A (DTA) driven by an SST-cre system to deplete these neurons in Sst(cre/gfp) mice (SST-DTA). Results SST-DTA mice exhibit enhanced hypothalamic c-Fos expression and brain inflammation as demonstrated by microglial and astrocytic activation. Bone marrow from SST-DTA mice undergoes skewed haematopoiesis, generating excess granulocyte-monocyte progenitors and increased proinflammatory (C-C chemokine receptor type 2; CCR2(hi)) monocytes. SST-DTA mice exhibited a 'diabetic retinopathy-like' phenotype: reduced visual function by optokinetic response (0.4 vs 0.25 cycles/degree; SST-DTA vs control mice); delayed electroretinogram oscillatory potentials; and increased percentages of retinal monocytes. Finally, mesenteric visceral adipose tissue from SST-DTA mice was resistant to catecholamine-induced lipolysis, displaying 50% reduction in isoprenaline (isoproterenol)-induced lipolysis compared with control littermates. Importantly, hyperglycaemia was not observed in SST-DTA mice. Conclusions/interpretation The isolated reduction in hypothalamic SST neurons was able to recapitulate several hallmark features of type 2 diabetes in disease-relevant tissues.
C1 [Huang, Chao; Rosencrans, Robert F.; Vieira, Cristiano P.; Hu, Ping; Adu-Agyeiwaah, Yvonne; Longhini, Ana Leda F.; Grant, Maria B.] Univ Alabama Birmingham, Dept Ophthalmol, Birmingham, AL 35294 USA.
   [Bugescu, Raluca; Leinninger, Gina M.] Michigan State Univ, Dept Physiol, E Lansing, MI 48824 USA.
   [Gamble, Karen L.] Univ Alabama Birmingham, Dept Psychiat & Neurobehav Neurobiol, Birmingham, AL USA.
   [Fuller, Patrick M.] Harvard Med Sch, Beth Israel Deaconess Med Ctr, Dept Neurol, Boston, MA 02115 USA.
   [Fuller, Patrick M.] Harvard Med Sch, Div Sleep Med, Boston, MA 02115 USA.
C3 University of Alabama System; University of Alabama Birmingham; Michigan
   State University; University of Alabama System; University of Alabama
   Birmingham; Harvard University; Harvard Medical School; Harvard
   University Medical Affiliates; Beth Israel Deaconess Medical Center;
   Harvard University; Harvard Medical School
RP Grant, MB (corresponding author), Univ Alabama Birmingham, Dept Ophthalmol, Birmingham, AL 35294 USA.
EM mariagrant@uabmc.edu
RI Gamble, Karen/A-1753-2010; Vieira, Cristiano/L-2517-2014; Longhini, Ana
   Leda/HJI-2866-2023; Adu-Rutledge, Yvonne/HMP-6877-2023
OI Adu-Rutledge, Yvonne/0000-0003-3899-7064; Gamble,
   Karen/0000-0003-3813-8577; Fuller, Patrick/0000-0002-7017-583X;
   Rosencrans, Robert/0000-0002-6268-989X
FU National Institutes of Health [R01EY028037 R01EY028037, R01EY012601,
   R01EY028858, R01EY025383]; NIH [DK059637, DK020593]; Medical Scientist
   Training Program [T32 GM008361]; Research to Prevent
   Blindness-Unrestricted Grants
FX This study was supported by grants from the National Institutes of
   Health (grant R01EY028037 R01EY028037, R01EY012601, R01EY028858 and
   R01EY025383 to MB) and Medical Scientist Training Program (grant T32
   GM008361), and by Research to Prevent Blindness-Unrestricted Grants. The
   Vanderbilt Hormone Assay Core is supported by NIH grants DK059637 (MMPC)
   and DK020593 (DRTC).
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NR 47
TC 7
Z9 8
U1 0
U2 5
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0012-186X
EI 1432-0428
J9 DIABETOLOGIA
JI Diabetologia
PD NOV
PY 2021
VL 64
IS 11
BP 2575
EP 2588
DI 10.1007/s00125-021-05549-6
EA AUG 2021
PG 14
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA WE8JT
UT WOS:000687948100001
PM 34430981
OA Bronze, Green Accepted, Green Submitted
DA 2025-06-11
ER

PT J
AU Kiapidou, S
   Liava, C
   Kalogirou, M
   Akriviadis, E
   Sinakos, E
AF Kiapidou, Stefania
   Liava, Christina
   Kalogirou, Maria
   Akriviadis, Evangelos
   Sinakos, Emmanouil
TI Chronic kidney disease in patients with non-alcoholic fatty liver
   disease: What the Hepatologist should know?
SO ANNALS OF HEPATOLOGY
LA English
DT Review
DE Non alcoholic fatty liver disease; Chronic kidney disease; Estimated
   glomerular filtration rate; Albumin to creatinine ratio; Kidney function
   markers
ID GLOMERULAR-FILTRATION-RATE; CYSTATIN-C; RENAL-FUNCTION;
   DIAGNOSTIC-ACCURACY; METABOLIC SYNDROME; SUBCLINICAL ATHEROSCLEROSIS;
   CARDIOVASCULAR-DISEASE; INCREASED PREVALENCE; ESTIMATING EQUATIONS;
   OXIDATIVE STRESS
AB The association of non-alcoholic fatty liver disease (NAFLD) with several other diseases has gained increased interest during the recent years. Among them, the association with chronic kidney disease (CKD) has emerged as an important one regarding both its prevalence and significance. The early recognition of this association is important for the prognosis of patients with NAFLD and CKD. Apart from early diagnosis, the accurate assessment of renal function is also crucial in the clinical practice of hepatologists. Several methods have been used in the literature for the evaluation of kidney function in patients with NAFLD up to now. In this respect, calculators (or formulas) for the estimation of Glomerular Filtration Rate (eGFR) and Albumin to Creatinine Ratio (ACR) are simple, practical and easily available methods for this purpose. The aim of this review is to report on the epidemiology and pathophysiology of the relationship between NAFLD and CKD and to describe the different methods of kidney function assessment in patients with NAFLD. The collection of all relevant data regarding this association will provide hepatologists with pertinent knowledge on this topic and allow them to use the most accurate methods for the assessment of kidney function in these patients in their clinical practice. (C) 2019 Fundacion Clinica Medica Sur, A.C. Published by Elsevier Espana, S.L.U.
C1 [Kiapidou, Stefania; Liava, Christina; Kalogirou, Maria; Akriviadis, Evangelos; Sinakos, Emmanouil] Aristotle Univ Thessaloniki, Hippokrat Gen Hosp Thessaloniki, Sch Med, Dept Internal Med 4, Thessaloniki, Greece.
C3 Aristotle University of Thessaloniki
RP Sinakos, E (corresponding author), Internal Med Hepatol, Konstantinoupoleos Str 46, Thessaloniki 54642, Greece.
EM esinakos@auth.gr
RI Sinakos, Emmanouil/ABI-4644-2020
OI Sinakos, Emmanouil/0000-0003-0923-050X
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NR 107
TC 34
Z9 35
U1 0
U2 6
PU ELSEVIER ESPANA
PI MADRID
PA CALLE DE ZURBANO, 76-4TH FLR LEFT, MADRID, 28010, SPAIN
SN 1665-2681
J9 ANN HEPATOL
JI Ann. Hepatol.
PD MAR-APR
PY 2020
VL 19
IS 2
BP 134
EP 144
DI 10.1016/j.aohep.2019.07.013
PG 11
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA KS6UO
UT WOS:000518442900004
PM 31606352
OA gold
DA 2025-06-11
ER

PT J
AU Jurado-Fasoli, L
   Amaro-Gahete, FJ
   De-la-O, A
   Martinez-Tellez, B
   Ruiz, JR
   Gutiérrez, A
   Castillo, MJ
AF Jurado-Fasoli, Lucas
   Amaro-Gahete, Francisco J.
   De-la-O, Alejandro
   Martinez-Tellez, Borja
   Ruiz, Jonatan R.
   Gutierrez, Angel
   Castillo, Manuel J.
TI Adherence to the Mediterranean diet, dietary factors, and S-Klotho
   plasma levels in sedentary middle-aged adults
SO EXPERIMENTAL GERONTOLOGY
LA English
DT Article
DE Ageing; Diet; Food; Food consumption; Lean mass
ID OXIDATIVE STRESS; METABOLIC SYNDROME; EXPRESSION; CONSUMPTION; GENE;
   POLYPHENOLS; PROTEIN; HEALTH; NUTS; MEN
AB Introduction: The ageing process can be influenced by different dietary patterns and dietary factors.
   Aim: To analyse the association of dietary factors, which include the Mediterranean diet adherence, the compliance with the "Sociedad Espanola de Nutricion Comunitaria" food portion recommendations, and the intake of different food groups, with the secreted form of the alpha-Klotho gene (S-Klotho as an anti-ageing marker) in middle-aged sedentary adults.
   Methods: A total of 74 (39 women) middle-aged sedentary adults participated in the study. Dietary factors were assessed with a food frequency questionnaire and the PREDIMED questionnaire. The S-Klotho plasma levels were measured using a soluble alpha-Klotho ELISA assay kit.
   Results: We observed: (i) a negative association between the adherence to the Mediterranean diet and the S-Klotho plasma levels (beta = - 53.219; R-2 = 0.078; P = 0.020), (ii) a higher intake of wine (> 7 glasses/week), was associated with lower S-Klotho plasma levels (P = 0.039), and (iii) a positive association between nuts portion intake and the S-Klotho plasma levels (beta = 26.087; R-2 = 0.070; P = 0.029). All the associations disappeared after controlling for lean mass index (LMI) (all P > 0.05).
   Conclusion: Our study suggests that, although dietary factors could be related to S-Klotho plasma levels in middle-aged sedentary adults, LMI is the main determinant in this regard.
C1 [Jurado-Fasoli, Lucas; Amaro-Gahete, Francisco J.; De-la-O, Alejandro; Gutierrez, Angel; Castillo, Manuel J.] Univ Granada, Sch Med, Dept Med Physiol, Granada, Spain.
   [Amaro-Gahete, Francisco J.; Martinez-Tellez, Borja; Ruiz, Jonatan R.] Univ Granada, Fac Sport Sci, PROmoting FITness & Hlth Phys Act Res Grp PROFITH, Dept Phys Educ & Sports, Granada, Spain.
   [Martinez-Tellez, Borja] Leiden Univ, Med Ctr, Dept Med, Div Endocrinol,Eindhoven Lab Expt Vasc Med, Leiden, Netherlands.
C3 University of Granada; University of Granada; Leiden University; Leiden
   University Medical Center (LUMC); Leiden University - Excl LUMC
RP Jurado-Fasoli, L (corresponding author), Univ Granada, Dept Med Physiol, Av Invest 11, Granada, Spain.
EM juradofasoli@ugr.es
RI Sainz, Angel/AAB-6809-2019; Téllez, Borja/AAS-3965-2021; Garzon,
   Manuel/AAB-6811-2019; Fasoli, Lucas/AAC-5217-2019; RUIZ,
   JONATAN/M-1338-2015; Amaro-Gahete, Francisco/AAB-4476-2019; Castillo
   Garzon, Manuel Joaquin/E-2242-2019
OI Jurado-Fasoli, Lucas/0000-0002-5254-1816; De-la-O,
   Alejandro/0000-0002-0614-4545; Amaro-Gahete, Francisco
   J./0000-0002-7207-9016; Gutierrez Sainz, Angel/0000-0003-2788-2739;
   Castillo Garzon, Manuel Joaquin/0000-0002-1196-9488
FU Spanish Ministry of Education [FPU14/04172, FPU15/03960]; University of
   Granada, Plan Propio de Investigacion 2016, Excellence actions: Units of
   Excellence; Unit of Excellence on Exercise and Health (UCEES)
FX The authors would like to thank all the participants that take part of
   the study for their time and effort. We are grateful to Ms. Carmen Sainz
   Quinn for assistance with the English language. This study is part of a
   Ph.D. Thesis conducted in the Biomedicine Doctoral Studies of the
   University of Granada, Spain. The study is supported by the Spanish
   Ministry of Education (FPU14/04172 and FPU15/03960). The study was
   partially supported by the University of Granada, Plan Propio de
   Investigacion 2016, Excellence actions: Units of Excellence; Unit of
   Excellence on Exercise and Health (UCEES).
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NR 50
TC 14
Z9 14
U1 0
U2 21
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0531-5565
EI 1873-6815
J9 EXP GERONTOL
JI Exp. Gerontol.
PD MAY
PY 2019
VL 119
BP 25
EP 32
DI 10.1016/j.exger.2019.01.019
PG 8
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA HN2FH
UT WOS:000460000600004
PM 30660660
DA 2025-06-11
ER

PT J
AU Mollazadeh, H
   Cicero, AFG
   Blesso, CN
   Pirro, M
   Majeed, M
   Sahebkar, A
AF Mollazadeh, Hamid
   Cicero, Arrigo F. G.
   Blesso, Christopher N.
   Pirro, Matteo
   Majeed, Muhammed
   Sahebkar, Amirhossein
TI Immune modulation by curcumin: The role of interleukin-10
SO CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
LA English
DT Review
DE chronic diseases; curcumin; human health; inflammation; interleukin-10
ID FATTY LIVER-DISEASE; ENDOTHELIAL PROGENITOR CELLS; RANDOMIZED
   CONTROLLED-TRIAL; T-HELPER-CELL; ANTIINFLAMMATORY CYTOKINE; METABOLIC
   SYNDROME; INFLAMMATORY CYTOKINES; BIOLOGICAL-ACTIVITIES; PIPERINE
   COMBINATION; PATHOLOGICAL PAIN
AB Cytokines are small secreted proteins released by different types of cells with specific effects on cellular signaling and communication via binding to their receptors on the cell surface. IL-10 is known to be a pleiotropic and potent anti-inflammatory and immunosuppressive cytokine that is produced by both innate and adaptive immunity cells including dendritic cells, macrophages, mast cells, natural killer cells, eosinophils, neutrophils, B cells, CD8(+) T cells, and T(H)1, T(H)2, and T(H)17 and regulatory T cells. Both direct and indirect activation of the stress axis promotes IL-10 secretion. IL-10 deregulation plays a role in the development of a large number of inflammatory diseases such as neuropathic pain, Parkinson's disease, Alzheimer's disease, osteoarthritis, rheumatoid arthritis, psoriasis, systemic lupus erythematosus, type 1 diabetes, inflammatory bowel disease, and allergy. Curcumin is a natural anti-inflammatory compound able to induce the expression and production of IL-10 and enhancing its action on a large number of tissues. In vitro and in pre-clinical models curcumin is able to modulate the disease pathophysiology of conditions such as pain and neurodegenerative diseases, bowel inflammation, and allergy, but also of infections and cancer through its effect on IL-10 secretion. In humans, at least one part of the positive effects of curcumin on health could be related to its ability to enhance IL-10 -mediated effects.
C1 [Mollazadeh, Hamid] North Khorasan Univ Med Sci, Sch Med, Dept Physiol & Pharmacol, Bojnurd, Iran.
   [Cicero, Arrigo F. G.] Univ Bologna, Dept Med & Surg Sci, Via Albertoni 15, Bologna, Italy.
   [Blesso, Christopher N.] Univ Connecticut, Dept Nutr Sci, Storrs, CT USA.
   [Pirro, Matteo] Univ Perugia, Dept Med, Unit Internal Med Angiol & Arteriosclerosis Dis, Perugia, Italy.
   [Majeed, Muhammed] Sabinsa Corp, East Windsor, NJ USA.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Biotechnol Res Ctr, Dept Med Biotechnol, Mashhad, Iran.
C3 North Khorasan University of Medical Sciences; University of Bologna;
   University of Connecticut; University of Perugia; Mashhad University of
   Medical Sciences
RP Sahebkar, A (corresponding author), Mashhad Univ Med Sci, Sch Med, Dept Med Biotechnol, POB 91779-48564, Mashhad, Iran.
EM sahebkara@mums.ac.ir
RI Pirro, Matteo/AAC-2318-2022; Cicero, Arrigo/H-8244-2019; Sahebkar,
   Amirhossein/B-5124-2018; Blesso, Christopher/N-9495-2014; Mollazadeh,
   Hamid/AAF-4313-2020
OI Cicero, Arrigo Francesco Giuseppe/0000-0002-4367-3884; mollazadeh,
   hamid/0000-0002-8157-5732; Pirro, Matteo/0000-0002-5527-4821
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NR 179
TC 286
Z9 299
U1 13
U2 285
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1040-8398
EI 1549-7852
J9 CRIT REV FOOD SCI
JI Crit. Rev. Food Sci. Nutr.
PD JAN 2
PY 2019
VL 59
IS 1
BP 89
EP 101
DI 10.1080/10408398.2017.1358139
PG 13
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA HM9PP
UT WOS:000459817600007
PM 28799796
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Lackner, N
   Bengesser, SA
   Birner, A
   Painold, A
   Fellendorf, FT
   Platzer, M
   Reininghaus, B
   Weiss, EM
   Mangge, H
   McIntyre, RS
   Fuchs, D
   Kapfhammer, HP
   Wallner-Liebmann, SJ
   Reininghaus, EZ
AF Lackner, N.
   Bengesser, S. A.
   Birner, A.
   Painold, A.
   Fellendorf, F. T.
   Platzer, M.
   Reininghaus, B.
   Weiss, E. M.
   Mangge, H.
   McIntyre, R. S.
   Fuchs, D.
   Kapfhammer, H. P.
   Wallner-Liebmann, S. J.
   Reininghaus, E. Z.
TI Abdominal obesity is associated with impaired cognitive function in
   euthymic bipolar individuals
SO WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
LA English
DT Article
DE bipolar disorder; overweight; body fat distribution; cognition; euthymia
ID BODY-MASS INDEX; C-REACTIVE PROTEIN; METABOLIC SYNDROME; OXIDATIVE
   STRESS; NEUROPSYCHOLOGICAL DEFICITS; MEDICAL COMORBIDITY;
   SEX-DIFFERENCES; MOOD DISORDERS; BRAIN; OVERWEIGHT
AB Objectives. Overweight/obesity has been implicated to play a role in cognitive deficits in bipolar disorder (BD). This study aims to identify the relationship between body fat distribution and different domains of cognition in BD during euthymia. Methods. A sample of 100 euthymic individuals with BD was measured with a cognitive test battery (i.e., Trail Making Test-A-B/TM-A/B, d2 Test of Attention, Stroop test, California Verbal Learning Test/CVLT) and an anthropometric measures set (body mass index, waist circumference, hip circumference, waist-to-hip-ratio, waist-to-height-ratio, and lipometry). Patient data were compared with a healthy control group (n = 64). Results. Results show that overweight patients with BD exhibit lower performance in the TMT-A/B as well as in the free recall performance of the CVLT compared to normal-weight patients with BD and controls. In bipolar individuals, (abdominal) obesity was significantly associated with a poor cognitive performance. In bipolar females, associations with measures of verbal learning and memory were found; in bipolar males, associations with poor performance in the TMT-A/B and in the Stroop interference task were demonstrated. In controls, no associations were found. Conclusions. There are several possible pathways moderating the association between obesity and cognition in BD. Anthropometric and lipometry data underline the substantial mediating impact of body fat distribution on cognition in BD.
C1 [Lackner, N.; Bengesser, S. A.; Birner, A.; Painold, A.; Fellendorf, F. T.; Platzer, M.; Kapfhammer, H. P.; Reininghaus, E. Z.] Med Univ Graz, Dept Psychiat, Graz, Austria.
   [Reininghaus, B.] Versicherungsanstalt Offentlich Bediensteter, Therapiezentrum Justuspk, Vienna, Austria.
   [Weiss, E. M.] Karl Franzens Univ Graz, Dept Biol Psychol, Graz, Austria.
   [Mangge, H.] Med Univ Graz, Res Unit Lifestyle & Inflammat Associated Risk Bi, Clin Inst Med & Chem Lab Diagnost, Graz, Austria.
   [Mangge, H.] BioTechMed Graz, Graz, Austria.
   [McIntyre, R. S.] Univ Toronto, Mood Disorders Psychopharmacol Unit, Toronto, ON, Canada.
   [Fuchs, D.] Med Univ Innsbruck, Div Biol Chem, Innsbruck, Austria.
   [Wallner-Liebmann, S. J.] Med Univ Graz, Dept Pathophysiol & Immunol, Graz, Austria.
C3 Medical University of Graz; University of Graz; Medical University of
   Graz; University of Toronto; Medical University of Innsbruck; Medical
   University of Graz
RP Bengesser, SA (corresponding author), Med Univ Graz, Auenburggerpl 31, A-8036 Graz, Austria.
EM susanne.bengesser@medunigraz.at
RI Fuchs, Dietmar/AAL-8011-2021; McIntyre, Roger/AAU-1000-2020
OI Reininghaus, Eva/0000-0001-5964-4087; Fuchs,
   Dietmar/0000-0003-1627-9563; Weiss, Elisabeth/0000-0003-1296-3448;
   Mangge, Harald/0000-0003-4067-247X; Fellendorf,
   Frederike/0000-0001-7215-3848
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NR 102
TC 45
Z9 45
U1 1
U2 27
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1562-2975
EI 1814-1412
J9 WORLD J BIOL PSYCHIA
JI World J. Biol. Psychiatry
PD OCT
PY 2016
VL 17
IS 7
BP 535
EP 546
DI 10.3109/15622975.2015.1046917
PG 12
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA DX2UK
UT WOS:000384226800006
PM 26068130
DA 2025-06-11
ER

PT J
AU Gainey, A
   Himathongkam, T
   Tanaka, H
   Suksom, D
AF Gainey, Atikarn
   Himathongkam, Thep
   Tanaka, Hirofumi
   Suksom, Daroonwan
TI Effects of Buddhist walking meditation on glycemic control and vascular
   function in patients with type 2 diabetes
SO COMPLEMENTARY THERAPIES IN MEDICINE
LA English
DT Article
DE Spirituality; Alternative and complementary medicine; Stress;
   Flow-mediated dilatation; Arterial stiffness
ID RANDOMIZED CONTROLLED-TRIAL; PERIPHERAL ARTERY-DISEASE; PULSE-WAVE
   VELOCITY; MIND-BODY MEDICINE; ENDOTHELIAL DYSFUNCTION; CARDIOVASCULAR
   RISK; INSULIN-RESISTANCE; MICROVASCULAR REACTIVITY; METABOLIC SYNDROME;
   PHYSICAL-FITNESS
AB Objective: To investigate and compare the effects of Buddhist walking meditation and traditional walking on glycemic control and vascular function in patients with type 2 diabetes mellitus.
   Methods: Twenty three patients with type 2 diabetes (50-75 years) were randomly allocated into traditional walking exercise (WE; n = 11) or Buddhism-based walking meditation exercise (WM; n = 12). Both groups performed a 12-week exercise program that consisted of walking on the treadmill at exercise intensity of 50-70% maximum heart rate for 30 min/session, 3 times/week. In the WM training program, the participants performed walking on the treadmill while concentrated on foot stepping by voiced "Budd" and "Dha" with each foot step that contacted the floor to practice mindfulness while walking.
   Results: After 12 weeks, maximal oxygen consumption increased and fasting blood glucose level decreased significantly in both groups (p < 0.05). Significant decrease in HbA1c and both systolic and diastolic blood pressure were observed only in the WM group. Flow-mediated dilatation increased significantly (p < 0.05) in both exercise groups but arterial stiffness was improved only in the WM group. Blood cortisol level was reduced (p < 0.05) only in the WM group.
   Conclusion: Buddhist walking meditation exercise produced a multitude of favorable effects, often superior to traditional walking program, in patients with type 2 diabetes. (C) 2016 Elsevier Ltd. All rights reserved.
C1 [Gainey, Atikarn; Suksom, Daroonwan] Chulalongkorn Univ, Fac Sports Sci, Rama 1 Rd, Bangkok 10330, Thailand.
   [Himathongkam, Thep] Theptarin Hosp, Bangkok, Thailand.
   [Tanaka, Hirofumi] Univ Texas Austin, Dept Kinesiol & Hlth Educ, Austin, TX 78712 USA.
C3 Chulalongkorn University; University of Texas System; University of
   Texas Austin
RP Suksom, D (corresponding author), Chulalongkorn Univ, Fac Sports Sci, Rama 1 Rd, Bangkok 10330, Thailand.
EM daroonwanc@hotmail.com
RI Tanaka, Hirofumi/AAB-3186-2022; Suksom, Daroonwan/KEH-7248-2024
OI Tanaka, Hirofumi/0000-0002-1780-7471
FU Faculty of Sports Science; 90th Anniversary of Chulalongkorn University
   Funds
FX The authors thank the subjects for participation. We also thank
   Napasakorn Chuensiri, Saowaluck Suntraluck and Tussana Charujata for
   assistance with data collection. This study was supported by the Faculty
   of Sports Science and the 90th Anniversary of Chulalongkorn University
   Funds.
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NR 55
TC 55
Z9 66
U1 1
U2 51
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0965-2299
EI 1873-6963
J9 COMPLEMENT THER MED
JI Complement. Ther. Med.
PD JUN
PY 2016
VL 26
BP 92
EP 97
DI 10.1016/j.ctim.2016.03.009
PG 6
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Integrative & Complementary Medicine
GA DP4FP
UT WOS:000378452000015
PM 27261988
DA 2025-06-11
ER

PT J
AU Navarro-Alarcon, M
   Ruiz-Ojeda, FJ
   Blanca-Herrera, RM
   Kaki, A
   Adem, A
   Agil, A
AF Navarro-Alarcon, Miguel
   Ruiz-Ojeda, Francisco J.
   Blanca-Herrera, Rosa M.
   Kaki, Abdullah
   Adem, Abdu
   Agil, Ahmad
TI Melatonin administration in diabetes: regulation of plasma Cr, V, and Mg
   in young male Zucker diabetic fatty rats
SO FOOD & FUNCTION
LA English
DT Article
ID CHROMIUM(III) PROPIONATE; INSULIN SENSITIVITY; METABOLIC SYNDROME;
   OXIDATIVE STRESS; DIETARY-INTAKE; DOUBLE-BLIND; GLUCOSE; MELLITUS;
   VANADIUM; OBESITY
AB The use of melatonin, a neurohormone present in plants, represents an exciting approach for the maintenance of optimum health conditions. Melatonin administration ameliorates glucose homeostasis in Zucker diabetic fatty (ZDF) rats. The objective of this study was to investigate the effects of melatonin in diabetes in relation to the levels and regulation of plasma chromium (Cr), vanadium (V), and magnesium (Mg) in Zucker diabetic fatty (ZDF) and Zucker lean (ZL) rats. At the age of 6 weeks, ZDF (n = 30) and ZL (n = 30) groups were each subdivided into three groups: control (C) (n = 10), vehicle-treated (V') (n = 10) and melatonin-treated (M) (10 mg kg(-1) per day; n = 10) groups for a 6 week period. After treatment, plasma mineral concentrations were measured by flame (Mg) and electrothermal (Cr and V) atomic absorption spectrometry. No significant differences were found between the C and V' groups (p > 0.05). Plasma Mg levels were significantly lower in C-ZDF vs. C-ZL rats, demonstrating the presence of hypomagnesemia in this diabetes mellitus model. Plasma V and Cr levels were significantly higher in M-ZDF vs. C-ZDF rats. Plasma Mg levels in ZDF rats were not affected by melatonin treatment (p > 0.05). Melatonin administration ameliorates the diabetic status of ZDF rats by enhancing plasma Cr and V concentrations. This appears to be the first report of a beneficial effect of melatonin treatment on plasma Cr and V regulation in ZDF rats.
C1 [Navarro-Alarcon, Miguel; Ruiz-Ojeda, Francisco J.; Blanca-Herrera, Rosa M.] Univ Granada, Sch Pharm, Dept Nutr & Food Sci, E-18071 Granada, Spain.
   [Kaki, Abdullah] King Abdulaziz Univ, KAU Hosp, Dept Anesthesia, Jeddah, Saudi Arabia.
   [Adem, Abdu] United Arab Emirates Univ, Fac Med & Hlth Sci, Dept Pharmacol, Al Ain, U Arab Emirates.
   [Agil, Ahmad] Univ Granada, Sch Med, Dept Pharmacol, E-18071 Granada, Spain.
   [Agil, Ahmad] Univ Granada, Sch Med, Neurosci Inst, E-18071 Granada, Spain.
C3 University of Granada; King Abdulaziz University; King Abdulaziz
   University Hospital - Jeddah; United Arab Emirates University;
   University of Granada; University of Granada
RP Navarro-Alarcon, M (corresponding author), Univ Granada, Sch Pharm, Dept Nutr & Food Sci, E-18071 Granada, Spain.
EM nalarcon@ugr.es
RI Navarro-Alarcon, Miguel/Q-4368-2019; Agil, Ahmad/D-9620-2014; Adem,
   Abdu/AAN-8271-2021; Ruiz Ojeda, Francisco Javier/D-1228-2016;
   Navarro-Alarcon, Miguel/K-6646-2014
OI Ruiz Ojeda, Francisco Javier/0000-0002-4452-0855; Navarro-Alarcon,
   Miguel/0000-0002-3189-3310; Agil, Ahmad/0000-0003-0164-9648
FU Junta de Andalucia [CTS-109, AGR-141]; University of Granada
FX This study was partially supported by grants from Greib Translational
   Projects and Convocatoria 2011 and Plan Propio-2012 of the University of
   Granada and from the Junta de Andalucia (CTS-109 and AGR-141 research
   groups). The authors are grateful to Antonio Tirado for technical
   assistance. The authors confirm that there are no conflicts of interest.
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NR 43
TC 5
Z9 5
U1 0
U2 10
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PD MAR
PY 2014
VL 5
IS 3
BP 512
EP 516
DI 10.1039/c3fo60389j
PG 5
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA AD4MU
UT WOS:000333226000011
PM 24441643
DA 2025-06-11
ER

PT J
AU de Oliveira, AM
   Rondó, PHC
   Luzia, LA
   D'Abronzo, FH
   Illison, VK
AF de Oliveira, Andreia Madruga
   Carvalho Rondo, Patricia Helen
   Luzia, Liania Alves
   D'Abronzo, Francisco Homero
   Illison, Vanessa Kristine
TI The effects of lipoic acid and α-tocopherol supplementation on the lipid
   profile and insulin sensitivity of patients with type 2 diabetes
   mellitus: A randomized, double-blind, placebo-controlled trial
SO DIABETES RESEARCH AND CLINICAL PRACTICE
LA English
DT Article
DE Type 2 diabetes mellitus; Lipoic acid; Vitamin E; Insulin resistance;
   Metabolic syndrome
ID LOW-DENSITY-LIPOPROTEIN; VITAMIN-E; OXIDATIVE STRESS; MACROVASCULAR
   COMPLICATIONS; NIDDM PATIENTS; HEART-DISEASE; ANTIOXIDANT; RESISTANCE;
   IMPACT
AB Antioxidants probably play an important role in the etiology of type 2 diabetes (DM2). This study evaluated the effects of supplementation with lipoic acid (LA) and alpha-tocopherol on the lipid profile and insulin sensitivity of DM2 patients.
   A randomized, double-blind, placebo-controlled trial involving 102 DM2 patients divided into four groups to receive daily supplementation for 4 months with: 600 mg LA (n = 26); 800 mg alpha-tocopherol (n = 25); 800 mg alpha-tocopherol + 600 mg LA (n = 25); placebo (n = 26). Plasma alpha-tocopherol, lipid profile, glucose, insulin, and the HOMA index were determined before and after supplementation. Differences within and between groups were compared by ANOVA using Bonferroni correction. Student's t-test was used to compare means of two independent variables.
   The vitamin E/total cholesterol ratio improved significantly in patients supplemented with vitamin E + LA and vitamin E alone (p <= 0.001). There were improvements of the lipid fractions in the groups receiving LA and vitamin E alone or in combination, and on the HOMA index in the LA group, but not significant.
   The results suggest that LA and vitamin E supplementation alone or in combination did not affect the lipid profile or insulin sensitivity of DM2 patients. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
C1 [de Oliveira, Andreia Madruga; Carvalho Rondo, Patricia Helen; Luzia, Liania Alves; Illison, Vanessa Kristine] Univ Sao Paulo, Sch Publ Hlth, Dept Nutr, BR-01246904 Sao Paulo, Brazil.
   [D'Abronzo, Francisco Homero] Jundiai Med Sch, Dept Internal Med, BR-13202550 Jundiai, SP, Brazil.
C3 Universidade de Sao Paulo; Faculdade de Medicina de Jundiai
RP Luzia, LA (corresponding author), Univ Sao Paulo, Sch Publ Hlth, Dept Nutr, Ave Dr Arnaldo 715, BR-01246904 Sao Paulo, Brazil.
EM lianialuzia@usp.br
RI Rondo; de carvalho rondo, Patricia/E-1936-2015
OI Rondo; de carvalho rondo, Patricia/0000-0002-8308-6393
FU Sao Paulo State Funding Agency - FAPESP, Brazil [2004/04108-1]
FX This study was supported by the Sao Paulo State Funding Agency - FAPESP,
   Brazil (grant2004/04108-1).
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NR 38
TC 65
Z9 68
U1 1
U2 22
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0168-8227
EI 1872-8227
J9 DIABETES RES CLIN PR
JI Diabetes Res. Clin. Pract.
PD MAY
PY 2011
VL 92
IS 2
BP 253
EP 260
DI 10.1016/j.diabres.2011.02.010
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 764ER
UT WOS:000290612200019
PM 21371770
OA Bronze
DA 2025-06-11
ER

PT J
AU Alberici, LC
   Oliveira, HCF
   Paim, BA
   Mantello, CC
   Augusto, AC
   Zecchin, KG
   Gurgueira, SA
   Kowaltowski, AJ
   Vercesi, AE
AF Alberici, Luciane C.
   Oliveira, Helena C. F.
   Paim, Bruno A.
   Mantello, Camila C.
   Augusto, Amanda C.
   Zecchin, Karina G.
   Gurgueira, Sonia A.
   Kowaltowski, Alicia J.
   Vercesi, Anibal E.
TI Mitochondrial ATP-sensitive K<SUP>+</SUP> channels as redox signals to
   liver mitochondria in response to hypertriglyceridemia
SO FREE RADICAL BIOLOGY AND MEDICINE
LA English
DT Article
DE Reactive oxygen species; Redox state; Mitochondrial uncoupling;
   Apolipoprotein-CIII transgenic mice; Free radicals
ID OXIDATIVE STRESS; METABOLIC SYNDROME; XANTHINE-OXIDASE; RAT-LIVER;
   NONALCOHOLIC STEATOHEPATITIS; SUPEROXIDE-DISMUTASE; DIABETES-MELLITUS;
   N-ACETYLCYSTEINE; LIPID PEROXIDES; MICE
AB We have recently demonstrated that hypertriglyceridemic (HTG) mice present both elevated body metabolic rates and mild mitochondrial uncoupling in the liver owing to stimulated activity of the ATP-sensitive potassium channel (mitoK(ATP)). Because lipid excess normally leads to cell redox imbalance, we examined the hepatic oxidative status in this model. Cell redox imbalance was evidenced by increased total levels of carbonylated proteins, malondialdehydes, and GSSG/GSH ratios in HTG livers compared to wild type. In addition, the activities of the extramitochondrial enzymes NADPH oxidase and xanthine oxidase were elevated in HTG livers. In contrast, Mn-superoxide dismutase activity and content, a mitochondrial matrix marker, were significantly decreased in HTG livers. isolated HTG liver mitochondria presented lower rates of H2O2 production, which were reversed by mitoK(ATP) antagonists. In vivo antioxidant treatment with N-acetylcysteine decreased both mitoKATP activity and metabolic rates in HTG mice. These data indicate that high levels of triglycerides increase reactive oxygen generation by extramitochondrial enzymes that promote MitoK(ATP) activation. The mild uncoupling mediated by mitoK(ATP) increases metabolic rates and protects mitochondria against oxidative damage. Therefore, a biological role for mitoK(ATP) is a redox sensor is shown here for the first time in an in vivo model of systemic and cellular lipid excess, (C) 2009 Elsevier Inc. All rights reserved.
C1 [Alberici, Luciane C.; Paim, Bruno A.; Mantello, Camila C.; Zecchin, Karina G.; Vercesi, Anibal E.] Univ Estadual Campinas, Fac Ciencias Med, Dept Patol Clin, BR-13083887 Campinas, SP, Brazil.
   [Oliveira, Helena C. F.] Univ Estadual Campinas, Inst Biol, Dept Fisiol & Biofis, BR-13083887 Campinas, SP, Brazil.
   [Augusto, Amanda C.; Gurgueira, Sonia A.] Univ Sao Francisco, Lab Estresse Oxidat, BR-12900000 Braganca Paulista, SP, Brazil.
   [Kowaltowski, Alicia J.] Univ Sao Paulo, Inst Quim, Dept Bioquim, BR-01498 Sao Paulo, Brazil.
C3 Universidade Estadual de Campinas; Universidade de Sao Paulo;
   Universidade Estadual de Campinas; Universidade Sao Francisco;
   Universidade de Sao Paulo
RP Vercesi, AE (corresponding author), Univ Estadual Campinas, Fac Ciencias Med, Dept Patol Clin, BR-13083887 Campinas, SP, Brazil.
EM anibal@unicamp.br
RI Vercesi, Aníbal/C-8767-2012; GURGUEIRA, SONIA/G-8775-2012; Kowaltowski,
   Alicia/H-8698-2012; Zecchin, Karina/F-5298-2013; Oliveira,
   Helena/C-1343-2013; Alberici, Luciane Carla/J-3013-2015
OI Campos Mantello, Camila/0000-0002-9716-0400; Oliveira,
   Helena/0000-0003-0119-6992; Gurgueira, Sonia/0000-0003-2928-1937;
   Vercesi, Anibal Eugenio/0000-0001-6671-7125; Alberici, Luciane
   Carla/0000-0002-7464-9385
FU Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP); Conselho
   Nacional para o Desenvolvimento Cientifico e Tecnologico
FX This work was supported by grants from the Fundacao de Amparo a Pesquisa
   do Estado de Sao Paulo (FAPESP) and Conselho Nacional para o
   Desenvolvimento Cientifico e Tecnologico (CNPq/INCT: National Institute
   for Science and Technology in Diabetes and Obesity). L.C.A. and K.G.Z.
   are supported by FAPESP fellowships. The authors thank Marisa H.G. de
   Medeiros and Camila C.M. Garcia from the Biochemistry Department at the
   University of Sao Paulo for help in quantifying the MDA.
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NR 54
TC 32
Z9 33
U1 0
U2 9
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0891-5849
EI 1873-4596
J9 FREE RADICAL BIO MED
JI Free Radic. Biol. Med.
PD NOV 15
PY 2009
VL 47
IS 10
BP 1432
EP 1439
DI 10.1016/j.freeradbiomed.2009.08.013
PG 8
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 521PO
UT WOS:000271934400014
PM 19703550
OA hybrid
DA 2025-06-11
ER

PT J
AU Koh, KK
   Quon, MJ
   Han, SH
   Chung, WJ
   Kim, JA
   Shin, EK
AF Koh, Kwang Kon
   Quon, Michael J.
   Han, Seung Hwan
   Chung, Wook-Jin
   Kim, Jeong-A
   Shin, Eak Kyun
TI Vascular and metabolic effects of candesartan: insights from therapeutic
   interventions
SO JOURNAL OF HYPERTENSION
LA English
DT Article; Proceedings Paper
CT International Workshop on Angiotensin II Receptor Blockade - Vascular
   and Organ Protective Effects
CY APR 28-30, 2005
CL Gouvieux, FRANCE
DE angiotensin II receptor blocker; endothelial function; adiponectin;
   insulin resistance; cardiovascular diseases
ID II TYPE-1 RECEPTOR; PLASMINOGEN-ACTIVATOR INHIBITOR-1;
   ANGIOTENSIN-CONVERTING ENZYME; CORONARY-ARTERY-DISEASE;
   SMOOTH-MUSCLE-CELLS; FACTOR-KAPPA-B; HYPERTENSIVE PATIENTS; AT(1)
   RECEPTOR; ENDOTHELIAL DYSFUNCTION; ADHESION MOLECULES
AB Background Effects of angiotensin 11 type 1 receptor blockers (ARBs) to improve endothelial dysfunction may be due to mechanisms in addition to the reduction of high blood pressure per se. Endothelial dysfunction is characterized by vascular inflammation that contributes to clinically significant atherosclerosis and by an increased tendency for thrombus formation. Hypertensive patients have impaired endothelial functions that have positive predictive power with respect to future cardiovascular events.
   Objectives The present review will focus on multiple mechanisms underlying vascular and metabolic effects of ARBs that may synergize to prevent or regress atherosclerosis, onset of diabetes, and coronary heart disease.
   Conclusions Angiotensin 11 accelerates the development of atherosclerosis by activating angiotensin 11 type 1 receptors that then promote superoxide anion generation and oxidative stress, leading to activation of nuclear transcription factor and endothelial dysfunction. Activation of angiotensin 11 type 1 receptors also stimulates increased expression of plasminogen activator inhibitor type 1 and tissue factor, Endothelial dysfunction associated with the metabolic syndrome and other insulin-resistant states is characterized by impaired insulin-stimulated production of nitric oxide from the endothelium and decreased blood flow to skeletal muscle. Increasing insulin sensitivity therefore improves endothelial function, and this may be an additional mechanism whereby ARBs decrease the incidence of coronary heart disease and the onset of diabetes. Adiponectin serves to link obesity with insulin resistance. In addition, adiponectin has anti-atherogenic properties.
C1 Gachon Med Sch, Vasc Med & Atherosclerosis Unit, Div Cardiol, Gil Heart Ctr, Inchon 405760, South Korea.
   NCCAM, Diabet Unit, Clin Invest Lab, NIH, Bethesda, MD USA.
C3 Gachon University; National Institutes of Health (NIH) - USA; NIH
   National Center for Complementary & Alternative Medicine (NCCAM)
RP Koh, KK (corresponding author), Gachon Med Sch, Vasc Med & Atherosclerosis Unit, Div Cardiol, Gil Heart Ctr, 1198 Kuwol Dong, Inchon 405760, South Korea.
EM kwangk@gilhospital.com
RI Quon, Michael/B-1970-2008; Chung, Wook-Jin/AAJ-5613-2021
OI Quon, Michael/0000-0002-9601-9915; Chung, Wook-Jin/0000-0002-9767-7098;
   QUON, MICHAEL/0000-0002-5289-3707
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NR 80
TC 19
Z9 21
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0263-6352
EI 1473-5598
J9 J HYPERTENS
JI J. Hypertens.
PD MAR
PY 2006
VL 24
SU 1
BP S31
EP S38
DI 10.1097/01.hjh.0000220404.38622.6a
PG 8
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Cardiovascular System & Cardiology
GA 043XE
UT WOS:000237635400006
PM 16601571
DA 2025-06-11
ER

PT J
AU Sharififar, F
   Ashrafzadeh, A
   Khanaman, MK
AF Sharififar, Fariba
   Ashrafzadeh, Anis
   Khanaman, Mahboubeh Kavirimanesh
TI A Review of Natural Peptide Sweeteners
SO INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS
LA English
DT Review
DE Natural peptide sweeteners; Protein structure; Low calories sweeteners;
   Diseases caused by sugar
ID FUNCTIONAL EXPRESSION; PROTEIN BRAZZEIN
AB The increasing prevalence of diseases caused by sugar consumption has become a threat to human health, and various studies have reported the relationship between high sugar consumption and the risk of various cardiovascular diseases, obesity, type 2 diabetes. Sugar-free products such as low-calorie sweeteners, especially peptide types, are very popular today due to the production of fewer calories. These sweeteners often have a protein structure and have a wide variety in terms of taste and dosage. Although extensive studies consider sweeteners to be safe and suitable substitutes for sugar, studies show that artificial types of these sweeteners can cause oxidative stress, metabolic syndrome, nervous system diseases, changes in the gastrointestinal microflora. Despite these conflicting studies, food safety organizations such as the FDA, FAO, EFSA limit the consumption of sweeteners to the acceptable daily intake (ADI) for all people, except for cases such as phenylketonuria. The purpose of this study is to briefly introduce natural peptide sweeteners (NPSs) that are good candidates to replace sugar and artificial sweeteners. The most important NPSs discussed in this summary include thaumatin, brazzein, monellin, curculin, miraculin, mabinlin, pentadin, whose safety, dosage and toxicity are discussed. Among the NPSs, thaumatin has been approved by FDA. This protein offers sweetness about 2000 times more than sucrose while produces only 4 kcal/g. NPSs generally show fewer side effects than synthetic types. The use of other NPS is also currently legal as a flavor enhancer and sugar substitute, but there are still challenges to their approval by the FDA.
C1 [Sharififar, Fariba] Kerman Univ Med Sci, Inst Neouropharmacol, Sch Pharm, Dept Pharmacognosy,Pharmaceut Res Ctr, Kerman, Iran.
   [Ashrafzadeh, Anis; Khanaman, Mahboubeh Kavirimanesh] Kerman Univ Med Sci, Herbal & Tradit Med Res Ctr, Sch Pharm, Kerman, Iran.
C3 Kerman University of Medical Sciences; Kerman University of Medical
   Sciences
RP Ashrafzadeh, A (corresponding author), Kerman Univ Med Sci, Herbal & Tradit Med Res Ctr, Sch Pharm, Kerman, Iran.
EM ashrafzadeh.anis@gmail.com
RI Sharififar, Fariba/ABB-8245-2020
OI Sharififar, Fariba/0000-0002-9057-1987
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NR 61
TC 3
Z9 4
U1 16
U2 119
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1573-3149
EI 1573-3904
J9 INT J PEPT RES THER
JI Int. J. Pept. Res. Ther.
PD OCT 31
PY 2022
VL 28
IS 6
AR 158
DI 10.1007/s10989-022-10464-4
PG 10
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 5V1BL
UT WOS:000876971800001
DA 2025-06-11
ER

PT J
AU He, QC
   Chen, BZ
   Huang, ZJ
   Zhao, J
   He, MA
   Luo, D
   Li, Q
   He, YF
   Wang, J
   Chen, X
   Shen, MX
   Duan, YY
AF He, Qican
   Chen, Bingzhi
   Huang, Zhijun
   Zhao, Jia
   He, Meian
   Luo, Dan
   Li, Qi
   He, Yuefeng
   Wang, Jing
   Chen, Xiang
   Shen, Minxue
   Duan, Yanying
TI Association of twenty-three plasma elements with fasting serum glucose
   among Chinese population from four areas with different pollution level
SO JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
LA English
DT Article
DE (78)Selenium; (208)Lead; (52)Chromium; (47)Titanium; Fasting serum
   glucose; Generalized linear regression model
ID TITANIUM-DIOXIDE NANOPARTICLES; CHROMIUM SUPPLEMENTATION; METABOLIC
   SYNDROME; OXIDATIVE STRESS; SELENIUM LEVELS; INSULIN; HOMEOSTASIS;
   METALS; EXPOSURE; ADULTS
AB Background: Association between fasting serum glucose (FSG) and certain mineral elements has been extensively reported. Investigation regarding multi-element exposure among subjects with different exposure level is warranted to confirm the association and further explore dose-dependent relationship.
   Methods: A total of 3488 participants were recruited from four counties of Hunan province, South China. Basic characteristics were collected by face to face interview and 23 elements in plasma were determined by inductively coupled plasma mass spectrometry. We applied fully adjusted generalized linear regression model and multivariable restricted cubic spline function to test the association and dose-response relationship of FSG with 23 elements.
   Results: The results indicated that FSG was positively associated with plasma (78)selenium level [regression coefficient (beta), 0.001; 95 % confidence interval (CI), 0.001, 0.001] in a dose-dependent manner, robust to the adjustment for suspected covariates and stratification by age, gender, BMI and smoking status. A negative association was found between FSG and plasma (208)lead (beta -0.004; 95 % CI, -0.016, -0.002), (52)chromium (beta-0.002; 95 % CI, -0.004, -0.001) and (47)titanium (beta -0.001; 95 % CI, -0.002, -0.001).
   Conclusion: (78)selenium was positively while (208)lead, (52)chromium and (47)titanium were negatively associated with FSG in the present study. However, prospective studies are needed to confirm the results.
C1 [He, Qican; Chen, Bingzhi; Duan, Yanying] Cent South Univ, Xiangya Sch Publ Hlth, Dept Occupat & Environm Hlth, Changsha 410078, Peoples R China.
   [Huang, Zhijun] Cent South Univ, Xiangya Hosp 3, Ctr Clin Pharmacol, Changsha 410013, Peoples R China.
   [Zhao, Jia] Hunan Agr Univ, Coll Resource & Environm, Environm Sci & Engn, Changsha 410128, Peoples R China.
   [He, Meian] Huazhong Univ Sci & Technol, Dept Occupat & Environm Hlth, Wuhan 430030, Peoples R China.
   [Luo, Dan; Shen, Minxue] Cent South Univ, Xiangya Sch Publ Hlth, Dept Social Med & Hlth Management, Changsha 410078, Peoples R China.
   [Li, Qi] Hunan Occupat Dis Prevent & Control Inst, Changsha 410007, Peoples R China.
   [He, Yuefeng] Kunming Med Univ, Publ Hlth Coll, Kunming 650500, Yunnan, Peoples R China.
   [Wang, Jing] Hubei Univ Med, Ctr Environm & Hlth Water Source Area South To No, Shiyan 442000, Peoples R China.
   [Chen, Xiang; Shen, Minxue] Cent South Univ, Xiangya Hosp, Dept Dermatol, Changsha 410008, Peoples R China.
C3 Central South University; Central South University; Hunan Agricultural
   University; Huazhong University of Science & Technology; Central South
   University; Kunming Medical University; Hubei University of Medicine;
   Central South University
RP Duan, YY (corresponding author), Cent South Univ, Xiangya Sch Publ Hlth, Dept Occupat & Environm Hlth, Changsha 410078, Peoples R China.
EM duany@csu.edu.cn
RI j, w/HGD-7409-2022; Shen, Minxue/P-5140-2019; HE, Qican/JOK-5092-2023;
   HUANG, ZHIJUN/KSM-2394-2024
OI Shen, Minxue/0000-0003-0441-9303; Wang, Jing/0000-0003-4869-7719; duan,
   yanying/0000-0001-9490-1720
FU National Key Research and Development Program Precision Medicine
   Initiative of China [2016YFC0900802]; National Basic Work of Science and
   Technology of China [2015FY111100]; Fundamental Research Funds for the
   Central Universities of Central South University [2018zzts852]
FX This work was finally supported by National Key Research and Development
   Program Precision Medicine Initiative of China (grant no:
   2016YFC0900802); National Basic Work of Science and Technology of China
   (2015FY111100); and Fundamental Research Funds for the Central
   Universities of Central South University (2018zzts852)
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NR 49
TC 8
Z9 9
U1 1
U2 19
PU ELSEVIER GMBH
PI MUNICH
PA HACKERBRUCKE 6, 80335 MUNICH, GERMANY
SN 0946-672X
J9 J TRACE ELEM MED BIO
JI J. Trace Elem. Med. Biol.
PD SEP
PY 2020
VL 61
AR 126510
DI 10.1016/j.jtemb.2020.126510
PG 8
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA MC6AG
UT WOS:000543366700010
PM 32416465
DA 2025-06-11
ER

PT J
AU Elshazly, SM
   Alsemeh, AE
   Ahmad, EAA
   Rezq, S
AF Elshazly, Shimaa M.
   Alsemeh, Amira E.
   Ahmad, Enssaf A. A.
   Rezq, Samar
TI CoQ10 exerts hepatoprotective effect in fructose-induced fatty liver
   model in rats
SO PHARMACOLOGICAL REPORTS
LA English
DT Article
DE Lipid profile; Adiponectin; Tyrosine kinase; PI3K
ID INSULIN-RESISTANCE; COENZYME Q(10); METABOLIC SYNDROME; OXIDATIVE
   STRESS; MESSENGER-RNA; APOPTOSIS; DISEASE; GLUCOSE; PROTEIN;
   INFLAMMATION
AB Background Excess dietary sugar is associated with deleterious metabolic effects, liver injury, and coenzyme-Q10 (CoQ10) deficiency. This study investigates the ability of CoQ10 to protect against fructose-induced hepatic damage. Methods Rats were fed tap water or 30% fructose for 12 weeks with or without CoQ10 (10 mg/kg, po). An additional group of rats were allowed to feed on either water or 30% fructose for 12 weeks, followed by four weeks of treatment with either the vehicle or CoQ10. Results Fructose-fed rats showed lower CoQ10 levels, increased systolic pressure, increased body weight, higher liquid consumption, decreased food intake and hyperglycemia. Fructose-fed rats also showed deteriorated serum and liver lipid profiles, impaired liver function tests and oxidative status, and lower expression of adiponectin receptor 1 and 2 along with higher GLUT-2 levels. Furthermore, following fructose treatment, tyrosine kinase-PI3K pathway was inhibited. Additionally, there was an increase in the levels of apoptotic markers and serum visfatin and a decrease in the levels of adiponectin and soluble receptor of the advanced glycated end product. Consequently, several histopathological changes were detected in the liver. Concurrent or three months post-exposure administration of CoQ10 in fructose rats significantly reversed or attenuated all the measured parameters and hepato-cytoarchitecture alterations. Conclusion This study suggests CoQ10 supplement as a possible prophylaxis or treatment candidate for fructose-induced liver injury. Graphic abstract
C1 [Elshazly, Shimaa M.; Rezq, Samar] Zagazig Univ, Fac Pharm, Dept Pharmacol & Toxicol, Zagazig, Egypt.
   [Alsemeh, Amira E.; Ahmad, Enssaf A. A.] Zagazig Univ, Fac Med, Dept Anat & Embryol, Zagazig, Egypt.
   [Rezq, Samar] UMMC, Dept Cell & Mol Biol, 2500 N State St, Jackson, MS 39216 USA.
C3 Egyptian Knowledge Bank (EKB); Zagazig University; Egyptian Knowledge
   Bank (EKB); Zagazig University; University of Mississippi Medical Center
RP Rezq, S (corresponding author), Zagazig Univ, Fac Pharm, Dept Pharmacol & Toxicol, Zagazig, Egypt.; Rezq, S (corresponding author), UMMC, Dept Cell & Mol Biol, 2500 N State St, Jackson, MS 39216 USA.
EM srezq@umc.edu
RI Alsemeh, Amira/LWH-9728-2024; Rezq, Samar/AAL-6255-2020; Ahmad,
   Enssaf/AAP-7737-2020
OI Rezq, Samar/0000-0003-4421-0686; Ahmad, Enssaf/0000-0003-0660-1942
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NR 49
TC 5
Z9 6
U1 1
U2 6
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1734-1140
EI 2299-5684
J9 PHARMACOL REP
JI Pharmacol. Rep.
PD AUG
PY 2020
VL 72
IS 4
BP 922
EP 934
DI 10.1007/s43440-020-00075-5
EA MAR 2020
PG 13
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA MP7QF
UT WOS:000523323800001
PM 32157594
DA 2025-06-11
ER

PT J
AU Klisic, A
   Kotur-Stevuljevic, J
   Kavaric, N
   Martinovic, M
   Matic, M
AF Klisic, Aleksandra
   Kotur-Stevuljevic, Jelena
   Kavaric, Nebojsa
   Martinovic, Milica
   Matic, Marija
TI The association between follicle stimulating hormone and glutathione
   peroxidase activity is dependent on abdominal obesity in postmenopausal
   women
SO EATING AND WEIGHT DISORDERS-STUDIES ON ANOREXIA BULIMIA AND OBESITY
LA English
DT Article
DE Antioxidant defense; Follicle stimulating hormone; Obesity;
   Postmenopausal women
ID METABOLIC SYNDROME; OXIDATIVE STRESS; REPRODUCTIVE HORMONES; OVERWEIGHT;
   PARAMETERS; ESTRADIOL; OXIDANT; WEIGHT; FSH
AB Purpose Menopause is frequently associated with an increase in visceral fat, thus modifying redox status by promoting oxidative damage and decreasing antioxidant defense systems. It is known that at higher concentrations estradiol has some antioxidant properties, while its decline in postmenopause is associated with pro-oxidant effects. However, the role of follicle stimulating hormone (FSH) in antioxidant defense in postmenopausal women is still not well elucidated. Therefore, we aimed to evaluate the potential complex association between visceral obesity, FSH and enzymatic antioxidant defense as measured by glutathione peroxidase (GPx) in postmenopausal women. Methods A total of 150 postmenopausal women (mean age 56.6 +/- 4.8 years), among them 50 normal weight and 100 overweight/obese, were included. GPx activity, FSH, luteinizing hormone, estradiol, total testosterone, cardiometabolic and anthropometric parameters, were determined.
   Results With increasing tertiles of serum FSH levels, significant increase in GPx activity (P = 0.005) was found. Also, the highest number of overweight/obese subjects were in the group with the lowest FSH values (chi(2) = 14.9, P < 0.001). After multiple linear regression analysis, the relationship between GPx and FSH disappeared, whereas only higher waist circumference (beta = -0.218, P = 0.045) predicted lower FSH level (adjusted R-2 = 0.227).
   Conclusion Higher GPx activity is associated with higher FSH level, but abdominal obesity may be the underlying determinant of this relationship.
C1 [Klisic, Aleksandra; Kavaric, Nebojsa] Primary Hlth Care Ctr, Trg Nikole Kovacevica 6, Podgorica 81000, Montenegro.
   [Kotur-Stevuljevic, Jelena] Univ Belgrade, Fac Pharm, Dept Med Biochem, Belgrade, Serbia.
   [Martinovic, Milica] Univ Montenegro, Med Fac, Dept Pathophysiol, Podgorica, Montenegro.
   [Martinovic, Milica] Univ Montenegro, Med Fac, Lab Med, Podgorica, Montenegro.
   [Matic, Marija] Univ Belgrade, Fac Med, Inst Med & Clin Biochem, Belgrade, Serbia.
C3 University of Belgrade; University of Montenegro; University of
   Montenegro; University of Belgrade
RP Klisic, A (corresponding author), Primary Hlth Care Ctr, Trg Nikole Kovacevica 6, Podgorica 81000, Montenegro.
EM aleksandranklisic@gmail.com
RI Klisic, Aleksandra/ABC-9219-2020
OI Klisic, Aleksandra/0000-0001-7870-0996; Matic,
   Marija/0000-0002-1488-3647
FU Ministry of Education, Science and Technological Development, Republic
   of Serbia [OI 175035-J]
FX This work was financially supported in part by a grant from the Ministry
   of Education, Science and Technological Development, Republic of Serbia
   (Project No. OI 175035-J. Kotur-Stevuljevic).
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NR 36
TC 19
Z9 20
U1 0
U2 4
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1124-4909
EI 1590-1262
J9 EAT WEIGHT DISORD-ST
JI Eat. Weight Disord.-Stud. Anorex.
PD FEB
PY 2018
VL 23
IS 1
BP 133
EP 141
DI 10.1007/s40519-016-0325-1
PG 9
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychiatry
GA FV5VC
UT WOS:000424649500015
PM 27663696
DA 2025-06-11
ER

PT J
AU Mateo-Gavira, I
   Vilchez-López, FJ
   García-Palacios, MV
   Laureano, FCS
   Visiedo-García, FM
   Aguilar-Diosdado, M
AF Mateo-Gavira, I.
   Vilchez-Lopez, F. J.
   Garcia-Palacios, M. V.
   Laureano, F. Carral-San
   Visiedo-Garcia, F. M.
   Aguilar-Diosdado, M.
TI Early blood pressure alterations are associated with pro-inflammatory
   markers in type 1 diabetes mellitus
SO JOURNAL OF HUMAN HYPERTENSION
LA English
DT Article
ID C-REACTIVE PROTEIN; LOW-GRADE INFLAMMATION; ENDOTHELIAL DYSFUNCTION;
   METABOLIC SYNDROME; MICROVASCULAR COMPLICATIONS; CARDIOVASCULAR-DISEASE;
   OXIDATIVE STRESS; RISK-FACTORS; HYPERTENSION; CYTOKINE
AB The aim of this study was to evaluate the relationship between early blood pressure (BP) changes (detected using ambulatory BP monitoring; ABPM) with different markers of inflammation and endothelial dysfunction in patients with type 1 diabetes mellitus (T1DM). The study design was observational cross-sectional in 85 T1DM patients, clinically normotensive and with normo-albuminuria. We analyzed the relationships between ABPM-measured BP alterations over 24 h with the inflammatory cytokines (interleukin-6 (IL-6), tumor necrosis factor-a and vascular endothelial growth factor (VEGF)) and the markers of endothelial damage (vascular adhesion molecule, intercellular adhesion molecule and plasminogen activator inhibitor-1 (PAI)). Despite being recorded as normotensive, 27 (31.8%) subjects presented with an average of pathological BP. VEGF levels were significantly elevated in the patients with an altered mean diurnal values compared with normotensives (112.33 (72.87-213.53) pg ml(-1) vs 71.03 (37.71-107.92) pg ml(-1); P = 0.007). Further, VEGF levels correlated significantly with the parameters of diurnal BP and of 24 h values. IL-6 concentration was a risk factor in the patients with hypertension (OR = 1.406; P = 0.027). There were no modifications in the levels of markers of endothelial damage. Summarizing, there is an increase in pro-inflammatory cytokines, but not the endothelial adhesion molecules, in early stages of arterial hypertension in patients with T1DM.
C1 [Mateo-Gavira, I.; Vilchez-Lopez, F. J.] Puerta del Mar Hosp, Dept Endocrinol, Cadiz, Spain.
   [Garcia-Palacios, M. V.] Puerta del Mar Hosp, Dept Prevent Med & Publ Hlth, Cadiz, Spain.
   [Laureano, F. Carral-San] Puerto Real Hosp, Dept Endocrinol, Cadiz, Spain.
   [Visiedo-Garcia, F. M.] Puerta del Mar Hosp, Dept Invest, Cadiz, Spain.
   [Aguilar-Diosdado, M.] Puerta del Mar Hosp, Dept Endocrinol & Invest Unit, Cadiz, Spain.
C3 Universidad de Cadiz; Hospital Universitario Puerta del Mar; Universidad
   de Cadiz; Hospital Universitario Puerta del Mar; Universidad de Cadiz;
   Hospital Universitario Puerta del Mar; Universidad de Cadiz; Hospital
   Universitario Puerta del Mar
RP Aguilar-Diosdado, M (corresponding author), Puerta del Mar Hosp, Dept Endocrinol & Nutr, Ana de Viya 21, Cadiz 11009, Spain.
EM manuel.aguilar.sspa@juntadeandalucia.es
RI San Laureano, Florentino/AAB-1576-2019; Visiedo Garcia,
   Francisco/M-3712-2014; Aguilar Diosdado, Manuel/A-2549-2009
OI Visiedo Garcia, Francisco/0000-0001-7834-0169; Aguilar Diosdado,
   Manuel/0000-0001-9657-5949; Garcia Palacios, Maria
   Victoria/0000-0002-2003-0966; Mateo-Gavira, Isabel/0000-0003-1793-9148
FU Spanish Diabetes Society
FX This study was financed, in part, by a grant from the Spanish Diabetes
   Society. Editorial assistance was by Dr Peter R Turner.
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NR 41
TC 6
Z9 6
U1 0
U2 6
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0950-9240
EI 1476-5527
J9 J HUM HYPERTENS
JI J. Hum. Hypertens.
PD FEB
PY 2017
VL 31
IS 2
BP 151
EP 156
DI 10.1038/jhh.2016.56
PG 6
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA EK7WX
UT WOS:000394137000012
PM 27535123
DA 2025-06-11
ER

PT J
AU Kim, GS
   Kim, SG
   Kim, HS
   Hwang, EY
   Lee, JH
   Yoon, H
AF Kim, Gwang Seok
   Kim, Sung Gil
   Kim, Han Soo
   Hwang, Eun Young
   Lee, Jun Ho
   Yoon, Hyun
TI The relationship between chronic kidney function and homeostasis model
   assessment of insulin resistance and beta cell function in Korean adults
   with or without type 2 diabetes mellitus
SO ENDOCRINE JOURNAL
LA English
DT Article
DE CKD; HOMA-IR; HOMA-B; T2DM
ID 3RD NATIONAL-HEALTH; NUTRITION EXAMINATION SURVEY; METABOLIC SYNDROME;
   GLUCOSE-TOLERANCE; DISEASE; PREVALENCE; EXPRESSION; STRESS; RISK; CKD
AB The present study was conducted to assess the relationship between chronic kidney disease (CKD) and the homeostasis model assessment of insulin resistance (HOMA-IR) and beta cell function (HOMA-B) in Korean adults with or without type 2 diabetes mellitus (T2DM). This study included 5,188 adults aged 20 or older using the 2015 Korea National Health and Nutrition Examination Survey (KNHANES) data, which represents national data in Korea. A covariance test adjusted for covariates was performed for HOMA-IR and HOMA-B in relation to CKD. The present study has several key findings. First, in T2DM, HOMA-IR (p = 0.035) was higher in the CKD group than in the non-CKD group after adjusting for the related variables but HOMA-B (p = 0.141) was not significant. Second, in non-T2DM, HOMA-IR (p = 0.163) and HOMA-B (p = 0.658) were not associated with CKD after adjusting for the related variables (except age). However, when further adjusted for age, HOMA-IR (p = 0.020) and HOMA-B (p = 0.006) were higher in the CKD group than in the non-CKD group. In conclusion, insulin resistance was positively associated CKD with in Korean adults with or without T2DM. Beta cell function was positively associated CKD with in Korean adults without T2DM but not in Korean adults with T2DM.
C1 [Kim, Gwang Seok] Chungbuk Hlth & Sci Univ, Dept Emergency Med Technol, Cheongju 28150, South Korea.
   [Kim, Sung Gil] Hanlyo Univ, Dept Radiol Sci, Gwangyang Si 57764, South Korea.
   [Kim, Han Soo] Chosun Univ, Grad Sch, Dept Hlth Sci, Gwangiu 61457, South Korea.
   [Hwang, Eun Young] Chosun Univ, Grad Sch, Dept Nursing, Gwangiu 61457, South Korea.
   [Lee, Jun Ho] Wonkwang Hlth Sci Univ, Dept Biomed Lab Sci, Iksan Si 54538, South Korea.
   [Yoon, Hyun] Hanlyo Univ, Dept Biomed Lab Sci, 94-13,Hallyeodae Gil, Gwangyang Si 57764, Jeollanam Do, South Korea.
C3 Chosun University; Chosun University
RP Yoon, H (corresponding author), Hanlyo Univ, Dept Biomed Lab Sci, 94-13,Hallyeodae Gil, Gwangyang Si 57764, Jeollanam Do, South Korea.
EM yh9074@yahoo.co.kr
RI yoon, hyun/E-6542-2015
OI yoon, hyun/0000-0002-4741-9664
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NR 49
TC 5
Z9 6
U1 0
U2 5
PU JAPAN ENDOCRINE SOC
PI KYOTO
PA 75  YANAGINOBANBA NISHIIRU-MASUYA-CHO, SANJOU-DORI, NAKAGYOU-KU, KYOTO,
   604-8111, JAPAN
SN 0918-8959
EI 1348-4540
J9 ENDOCR J
JI Endocr. J.
PY 2017
VL 64
IS 12
BP 1181
EP 1190
DI 10.1507/endocrj.EJ17-0274
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA FR0QZ
UT WOS:000418769300008
PM 28890482
OA gold
DA 2025-06-11
ER

PT J
AU Candela, J
   Velmurugan, GV
   White, C
AF Candela, Joseph
   Velmurugan, Gopal V.
   White, Carl
TI Hydrogen sulfide depletion contributes to microvascular remodeling in
   obesity
SO AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
LA English
DT Article
DE hydrogen sulfide; microvascular; obesity; extracellular matrix;
   remodeling
ID SMALL-ARTERY STRUCTURE; TISSUE GROWTH-FACTOR; SUBCUTANEOUS SMALL
   ARTERIES; DIET-INDUCED OBESITY; SMOOTH-MUSCLE-CELLS; RESISTANCE
   ARTERIES; METABOLIC SYNDROME; ENDOTHELIAL DYSFUNCTION; OXIDATIVE STRESS;
   DEFICIENT MICE
AB Structural remodeling of the microvasculature occurs during obesity. Based on observations that impaired H2S signaling is associated with cardiovascular pathologies, the current study was designed to test the hypothesis that altered H2S homeostasis is involved in driving the remodeling process in a diet-induced mouse model of obesity. The structural and passive mechanical properties of mesenteric resistance arterioles isolated from 30-wk-old lean and obese mice were assessed using pressure myography, and vessel H2S levels were quantified using the H2S indicator sulfidefluor 7-AM. Remodeling gene expression was assessed using quantitative RT-PCR, and histological staining was used to quantify vessel collagen and elastin. Obesity was found to be associated with decreased vessel H2S concentration, inward hypertrophic remodeling, altered collagen-to-elastin ratio, and reduced vessel stiffness. In addition, mRNA levels of fibronectin, collagen types I and III, matrix metalloproteinases 2 and 9, and tissue inhibitor of metalloproteinase 1 were increased and elastin was decreased by obesity. Evidence that decreased H2S was responsible for the genetic changes was provided by experiments in which H2S levels were manipulated, either by inhibition of the H2S-generating enzyme cystathionine gamma-lyase with DL-propargylglycine or by incubation with the H2S donor GYY4137. These data suggest that, during obesity, depletion of H2S is involved in orchestrating the genetic changes underpinning inward hypertrophic remodeling in the microvasculature.
C1 [Candela, Joseph; Velmurugan, Gopal V.; White, Carl] Rosalind Franklin Univ Med & Sci, Chicago Med Sch, Dept Physiol & Biophys, 3333 Green Bay Rd, N Chicago, IL 60064 USA.
C3 Rosalind Franklin University of Medicine & Science; Chicago Medical
   School
RP White, C (corresponding author), Rosalind Franklin Univ Med & Sci, Chicago Med Sch, Dept Physiol & Biophys, 3333 Green Bay Rd, N Chicago, IL 60064 USA.
EM carl.white@rosalindfranklin.edu
OI White, Carl/0000-0002-0535-6968
FU Rosalind Franklin University; American Heart Association Scientist
   Development Grant [10SDG4180042]; Chicago Medical School; James R. &
   Helen D. Russell Institute for Research & Innovation Translational
   Research Pilot Grant, Advocate Lutheran General Hospital, Park Ridge,
   IL; Calcium Imaging Research Support and Molecular Quantification
   Laboratories, Rosalind Franklin University; American Heart Association
   (AHA) [10SDG4180042] Funding Source: American Heart Association (AHA)
FX Funding was provided by Rosalind Franklin University and American Heart
   Association Scientist Development Grant 10SDG4180042 (to C. White);
   additional financial support and project oversight were provided by the
   Chicago Medical School and James R. & Helen D. Russell Institute for
   Research & Innovation Translational Research Pilot Grant, Advocate
   Lutheran General Hospital, Park Ridge, IL. Work was carried out, in
   part, with the support of the Calcium Imaging Research Support and
   Molecular Quantification Laboratories, Rosalind Franklin University.
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   Zhao X, 2008, HYPERTENS RES, V31, P1619, DOI 10.1291/hypres.31.1619
NR 71
TC 17
Z9 19
U1 0
U2 4
PU AMER PHYSIOLOGICAL SOC
PI Rockville
PA 6120 Executive Blvd, Suite 600, Rockville, MD, UNITED STATES
SN 0363-6135
EI 1522-1539
J9 AM J PHYSIOL-HEART C
JI Am. J. Physiol.-Heart Circul. Physiol.
PD MAY 1
PY 2016
VL 310
IS 9
BP H1071
EP H1080
DI 10.1152/ajpheart.00062.2016
PG 10
WC Cardiac & Cardiovascular Systems; Physiology; Peripheral Vascular
   Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Physiology
GA DK7OA
UT WOS:000375114200004
PM 26993223
OA Bronze
DA 2025-06-11
ER

PT J
AU Han, KS
   Cho, DY
   Kim, YS
   Kim, KN
AF Han, Kyung-Sun
   Cho, Doo-Yeoun
   Kim, Young-Sang
   Kim, Kyu-Nam
TI Serum Gamma-glutamyl Transferase Concentration Within the Reference
   Range is Related to the Coronary Heart Disease Risk Prediction in Korean
   Men: Analysis of the Korea National Health and Nutrition Examination
   Survey (V-1, 2010 and V-2, 2011)
SO CHINESE MEDICAL JOURNAL
LA English
DT Article
DE Framingham Risk Score; Gamma-glutamyl Transferase; Reference Range
ID METABOLIC SYNDROME; OXIDATIVE STRESS; CARDIOVASCULAR-DISEASE;
   POPULATION; ENZYMES; PLAQUE; BLOOD; SCORE
AB Background: Limited data exist on the association of serum gamma-glutamyl transferase (GGT) level within the reference range with the increased risk of coronary heart disease (CHD) prediction in men. The study examined the association between serum GGT concentration within the reference range and the CHD risk prediction in Korean men.
   Methods: The study employed data from Korean National Health and Nutrition Examination Survey (V-1, 2010 and V-2, 2011) where a total of 1301 individuals were analyzed. A 10-year CHD risk prediction was computed using the Framingham Risk Score (FRS) modified by the National Cholesterol Education Program (NCEP) Adult Treatment Panel III (ATP III).
   Results: Positive correlations were established between log-transformed GGT concentration and FRS (r = 0.237, P < 0.001). After adjustment of body mass index, the amount of alcohol intake and low-density lipoprotein-cholesterol, the odds ratio (95% confidence interval) for intermediate risk and beyond of 10-year CHD prediction (10-year risk >= 10%) with lowest quartile of participants was 1.21 (0.78-1.87) for second quartiles, 1.39 (0.88-2.21) for third quartiles and 2.03 (1.23-3.34) for highest quartiles.
   Conclusions: Higher serum GGT within its reference range was significantly correlated with a 10-year CHD risk prediction estimation using NCEP ATP III in Korean men.
C1 [Han, Kyung-Sun; Cho, Doo-Yeoun; Kim, Kyu-Nam] Ajou Univ, Sch Med, Dept Family Practice & Community Hlth, Suwon 441749, Gyeonggi Do, South Korea.
   [Kim, Young-Sang] Cha Univ, Dept Family Med, Cha Bundang Med Ctr, Songnam, Gyeonggi Do, South Korea.
C3 Ajou University; Pochon Cha University
RP Kim, KN (corresponding author), Ajou Univ, Sch Med, Dept Family Practice & Community Hlth, 164 Worldcup Ro, Suwon 441749, Gyeonggi Do, South Korea.
EM ktwonm@hanmail.net
RI ; Cho, Doo-Yeoun/E-2372-2019
OI Han, Kyungsun/0000-0002-9710-7845; Cho, Doo-Yeoun/0000-0003-2996-1000
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NR 35
TC 5
Z9 6
U1 0
U2 7
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, 400059, INDIA
SN 0366-6999
J9 CHINESE MED J-PEKING
JI Chin. Med. J.
PD AUG 5
PY 2015
VL 128
IS 15
BP 2006
EP 2011
DI 10.4103/0366-6999.161343
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA CN7NW
UT WOS:000358622300004
PM 26228210
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Andrade, JMO
   Paraíso, AF
   Garcia, ZM
   Ferreira, AVM
   Sinisterra, RDM
   Sousa, FB
   Guimaraes, ALS
   de Paula, AMB
   Campagnole-Santos, MJ
   dos Santos, RA
   Santos, SHS
AF Oliveira Andrade, Joao Marcus
   Paraiso, Alanna Fernandes
   Garcia, Zelia Menezes
   Matos Ferreira, Adaliene Versiani
   Sinisterra, Ruben D. M.
   Sousa, Frederico B.
   Sena Guimaraes, Andre Luiz
   Batista de Paula, Alfredo Mauricio
   Campagnole-Santos, Maria Jose
   dos Santos, Robson Augusto
   Sousa Santos, Sergio Henrique
TI Cross talk between angiotensin-(1-7)/Mas axis and sirtuins in adipose
   tissue and metabolism of high-fat feed mice
SO PEPTIDES
LA English
DT Article
DE Resveratrol; Rennin-angiotensin system; Ang-(1-7); Obesity; Metabolic
   syndrome
ID INCREASED CIRCULATING ANGIOTENSIN-(1-7); HIGH-CALORIE DIET;
   INSULIN-RESISTANCE; CLINICAL-IMPLICATIONS; OXIDATIVE STRESS;
   LIPID-METABOLISM; TRANSGENIC RATS; FOOD-INTAKE; SIRT1; RESVERATROL
AB Angiotensin-(1-7) and resveratrol have been described as new potential therapeutic tools on treating and preventing metabolic disorders. In the present study we aimed to evaluate the effect of an oral formulation of angiotensin-(1-7) [Ang-(1-7)] included in HPB-cyclodextrin and resveratrol (RSV), in modulation of sirtuin and renin-angiotensin system (RAS) in adipose tissue of mice treated with a highfat diet (HFD). We observed that HFD + Ang-(1-7) and HFD + RSV groups presented marked decrease in the adipose tissue mass. Furthermore, these animals showed improved insulin-sensitivity and glucose tolerance as well as lower plasma levels of fasting glucose and lipids. The RT-PCR analysis revealed decreased expression of ACE and an increase of ACE2 [Ang-(1-7) marker] in group treated with resveratrol and also an increased expression of SIRT1 in groups that received Ang-( 1-7). We showed for the first time that improved metabolic profile is associated with increased expression of GLUT4 and high expression of A1VIPKIFOX01/PPAR--y pathway in adipose-tissue. Finally, adipocyte primary cell-culture incubated with and without sirtuin and Ang-(1-7)/Mas antagonists pointed out for a cross-talking between RAS and sirtuins. We conclude that oral administration of Ang-(1-7) and RSV improved metabolic profile through a cross-modulation between RAS and Sirtuins. (C) 2014 Elsevier Inc. All rights reserved.
C1 [Oliveira Andrade, Joao Marcus; Paraiso, Alanna Fernandes; Sena Guimaraes, Andre Luiz; Batista de Paula, Alfredo Mauricio; Sousa Santos, Sergio Henrique] Univ Estadual Montes Claros, Lab Hlth Sci, Postgrad Program Hlth Sci, Montes Claros, MG, Brazil.
   [Garcia, Zelia Menezes] Univ Fed Minas Gerais, Microbiol Lab, Postgrad Program Microbiol, BR-31270901 Belo Horizonte, MG, Brazil.
   [Matos Ferreira, Adaliene Versiani] Univ Fed Minas Gerais, Sch Nutr, Dept Basic Nursing, BR-31270901 Belo Horizonte, MG, Brazil.
   [Sinisterra, Ruben D. M.; Sousa, Frederico B.] Univ Fed Minas Gerais, Dept Chem, BR-31270901 Belo Horizonte, MG, Brazil.
   [Campagnole-Santos, Maria Jose; dos Santos, Robson Augusto; Sousa Santos, Sergio Henrique] Univ Fed Minas Gerais, Inst Biol Sci, Dept Pharmacol, BR-31270901 Belo Horizonte, MG, Brazil.
   [Sousa Santos, Sergio Henrique] Univ Fed Minas Gerais, Dept Physiol & Biophys, BR-31270901 Belo Horizonte, MG, Brazil.
   [Sena Guimaraes, Andre Luiz; Batista de Paula, Alfredo Mauricio] Univ Estadual Montes Claros, Dept Dent, BR-31270901 Montes Claros, MG, Brazil.
C3 Universidade Estadual de Montes Claros; Universidade Federal de Minas
   Gerais; Universidade Federal de Minas Gerais; Universidade Federal de
   Minas Gerais; Universidade Federal de Minas Gerais; Universidade Federal
   de Minas Gerais; Universidade Estadual de Montes Claros
RP Santos, SHS (corresponding author), Univ Fed Minas Gerais, Dept Pharmacol, Av Antonio Carlos 6627 ICB, BR-31270901 Belo Horizonte, MG, Brazil.
EM sergiosousas@hotmail.com
RI De Paula, Alfredo/K-3015-2012; Andrade, Joao/K-4072-2015; Santos,
   Robson/C-9336-2011; Sinisterra, Ruben/AAD-8965-2020; Campagnole-Santos,
   Maria/AAK-7515-2020; Santos, Sérgio/D-8143-2011; Campagnole-Santos,
   Maria/F-5590-2017; Ferreira, adaliene/G-8523-2011; Guimaraes,
   Andre/D-8122-2011; De Sousa, Frederico/H-1690-2014
OI Campagnole-Santos, Maria/0000-0001-9483-4206; Ferreira,
   adaliene/0000-0003-2256-8652; Fernandes Paraiso,
   Alanna/0000-0001-7400-140X; Guimaraes, Andre/0000-0002-3162-3206;
   Sinisterra, Ruben/0000-0001-7656-1849; Santos,
   Robson/0000-0001-8738-5852; De Sousa, Frederico/0000-0002-7930-6867;
   Santos, Sergio/0000-0002-7788-5447
FU Coordenadoria de Aperfeicoamento do Pessoal de Nivel Superior (CAPES);
   Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq);
   Fundacao de Amparo a Pesquisa de Minas Gerais (FAPEMIG); PRONEX
   [APQ04758-10 (CNPq/FAPEMIG)]
FX Thank R.A.S. by availability of Ang-(1-7). This work was supported by
   grants from Coordenadoria de Aperfeicoamento do Pessoal de Nivel
   Superior (CAPES), Conselho Nacional de Desenvolvimento Cientifico e
   Tecnologico (CNPq) and Fundacao de Amparo a Pesquisa de Minas Gerais
   (FAPEMIG) and PRONEX APQ04758-10 (CNPq/FAPEMIG).
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NR 59
TC 67
Z9 69
U1 0
U2 23
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0196-9781
EI 1873-5169
J9 PEPTIDES
JI Peptides
PD MAY
PY 2014
VL 55
BP 158
EP 165
DI 10.1016/j.peptides.2014.03.006
PG 8
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism;
   Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism;
   Pharmacology & Pharmacy
GA AG6BR
UT WOS:000335503900023
PM 24642355
DA 2025-06-11
ER

PT J
AU Beltowski, J
AF Beltowski, Jerzy
TI Endogenous hydrogen sulfide in perivascular adipose tissue: role in the
   regulation of vascular tone in physiology and pathology
SO CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
LA English
DT Review
DE hydrogen sulfide; perivascular adipose tissue; obesity; metabolic
   syndrome; arterial hypertension; vascular tone; insulin sensitivity;
   hypoxia; endocannabinoids
ID CYSTATHIONINE-BETA-SYNTHASE; MESENTERIC SMALL ARTERIES; NITRIC-OXIDE;
   3-MERCAPTOPYRUVATE SULFURTRANSFERASE; GAMMA-LYASE; ENDOTHELIAL
   DYSFUNCTION; HOMOCYSTEINE METABOLISM; OXIDATIVE STRESS; SULFANE SULFUR;
   BLOOD-PRESSURE
AB Hydrogen sulfide (H2S) is synthesized from L-cysteine by cystathionine beta-synthase (CBS) or cystathionine gamma-lyase (CSE), and is enzymatically metabolized in mitochondria by sulfide: quinone oxidoreductase (SQR). Recent studies have indicated that H2S is synthesized by CSE in perivascular adipose tissue (PVAT), and is responsible for the anticontractile effect of PVAT on adjacent vessels. The lipophilic statin atorvastatin increases PVAT-derived H2S by suppressing its mitochondrial oxidation; the effect that results from statin-induced depletion of ubiquinone. Experimental obesity induced by a highly palatable diet has a time-dependent effect on H2S in PVAT. Adipose tissue hypoxia suppresses H2S oxidation and increases its level in short-term obesity not associated with insulin resistance. In contrast, in long-term obesity, insulin resistance and (or) hyperinsulinemia result in the down-regulation of CSE and H2S deficiency, which is corrected by treatment with the insulin sensitizer rosiglitazone. In addition, cannabinoid CB1 receptor agonist administered for 2 weeks increases H2S by impairing mitochondria biogenesis. This indicates that the rate of mitochondrial H2S oxidation plays an important role in the regulation of H2S level in PVAT. Up-regulation of H2S signaling in short-term obesity and (or) by elevated endocannabinoids may be a compensatory mechanism that maintains vascular tone, despite endothelial dysfunction.
C1 Med Univ Lublin, Dept Pathophysiol, PL-20090 Lublin, Poland.
C3 Medical University of Lublin
RP Beltowski, J (corresponding author), Med Univ Lublin, Dept Pathophysiol, Ulica Jaczewskiego 8, PL-20090 Lublin, Poland.
EM jerzy.beltowski@umlub.pl
RI Beltowski, Jerzy/AAH-4692-2020
OI Beltowski, Jerzy/0000-0001-7903-8121
FU Medical University, Lublin, Poland [DS 476]; EU
FX The author's studies cited in this paper were supported by grant DS 476
   from the Medical University, Lublin, Poland, as well as by an EU
   Project: "The equipment of innovative laboratories doing research on new
   medicines used in the therapy of civilization and neoplastic diseases"
   within the Operational Program Development of Eastern Poland 2007-2013,
   Priority Axis I Modern Economy, Operations I.3 Innovation Promotion.
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NR 122
TC 46
Z9 50
U1 0
U2 38
PU CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS
PI OTTAWA
PA 65 AURIGA DR, SUITE 203, OTTAWA, ON K2E 7W6, CANADA
SN 0008-4212
EI 1205-7541
J9 CAN J PHYSIOL PHARM
JI Can. J. Physiol. Pharmacol.
PD NOV
PY 2013
VL 91
IS 11
BP 889
EP 898
DI 10.1139/cjpp-2013-0001
PG 10
WC Pharmacology & Pharmacy; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Physiology
GA 235WJ
UT WOS:000325751900005
PM 24117256
DA 2025-06-11
ER

PT J
AU Chang, JW
   Chen, HL
   Chang, CC
   Su, HJ
   Liao, PC
   Lee, CC
AF Chang, Jung-Wei
   Chen, Hsiu-Ling
   Chang, Chih-Ching
   Su, Huey-Jen
   Liao, Po-Chi
   Lee, Ching-Chang
TI Predicting the risk of cardiovascular disease in people exposed to
   moderate to high levels of dioxin
SO JOURNAL OF HAZARDOUS MATERIALS
LA English
DT Article
DE PCDD/Fs; Framingham risk score; Cardiovascular disease
ID NITRIC-OXIDE SYNTHASE; METABOLIC SYNDROME; HEART-DISEASE; ORGANIC
   POLLUTANTS; INSULIN-RESISTANCE; ESTROGEN-RECEPTOR; OXIDATIVE STRESS;
   FOLLOW-UP; SERUM; HYPERTENSION
AB Cardiovascular disease (CVD) is a leading cause of morbidity and mortality worldwide. Dioxins can cause cardiovascular toxicity in experimental animals. The potential role of dioxin exposure as a preventable risk factor has attracted the attention of public health services, especially because dioxin exposure is a ubiquitous problem. We aimed to investigate and clarify the effect on CVD risk of moderate-to-high exposure to dioxins. This cross-sectional study investigated 914 residents without CVD near a deserted pentachlorophenol factory. CVD-related factors were measured to examine their associations with serum dioxin. We also investigated associations between serum dioxins and the Framingham risk score. Serum PCDD/F levels were significantly positively associated with CVD risk in both genders (Men: b=0.023, P< 0.001; Women: b=0.005, P< 0.001; All: b=0.013, P<0.001). After adjusting for confounding factors, participants with higher serum PCDD/F levels had a higher risk for CVD than did the reference group (serum PCDD/levels <9.8 pg WHO98-TEQ(DF)/g lipid) (25th to <50th percentile, adjusted odds ratio (AOR)=2.96 [95% confidence interval (Cl)= 1.13-7.75]; 50th to < 75th percentile, AOR =3.37[1.32-8.59]; >= 75th percentile, AOR= 6.22 [2.47-15.63]). We hypothesize that accumulated dioxins heightens the cardiovascular risk. (C) 2011 Elsevier B.V. All rights reserved.
C1 [Chang, Jung-Wei; Chang, Chih-Ching; Su, Huey-Jen; Liao, Po-Chi; Lee, Ching-Chang] Natl Cheng Kung Univ, Coll Med, Dept Environm & Occupat Hlth, Tainan 704, Taiwan.
   [Chen, Hsiu-Ling] Hung Kuang Univ, Dept Ind Safety & Hlth, Taichung, Taiwan.
   [Su, Huey-Jen; Liao, Po-Chi; Lee, Ching-Chang] Natl Cheng Kung Univ, Res Ctr Environm Trace Toxic Subst, Tainan 704, Taiwan.
C3 National Cheng Kung University; Hungkuang University; National Cheng
   Kung University
RP Lee, CC (corresponding author), Natl Cheng Kung Univ, Coll Med, Dept Environm & Occupat Hlth, 138 Sheng Li Rd, Tainan 704, Taiwan.
EM cclee@mail.ncku.edu.tw
RI chen, chiyu/KYQ-5930-2024; Chung, Chi-Jung/G-4755-2013
OI Chen, Hsiu-Ling/0000-0002-1209-6789; Su, Huey-Jen/0000-0003-3589-9987
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NR 47
TC 2
Z9 3
U1 0
U2 15
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0304-3894
EI 1873-3336
J9 J HAZARD MATER
JI J. Hazard. Mater.
PD DEC 30
PY 2011
VL 198
BP 317
EP 322
DI 10.1016/j.jhazmat.2011.10.046
PG 6
WC Engineering, Environmental; Environmental Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering; Environmental Sciences & Ecology
GA 872AL
UT WOS:000298778700039
PM 22074891
DA 2025-06-11
ER

PT J
AU Chapela, SP
   Martinuzzi, ALN
   Llobera, ND
   Ceriani, F
   Gonzalez, V
   Montalvan, M
   Verde, L
   Frias-Toral, E
AF Chapela, Sebastian Pablo
   Martinuzzi, Andres Luciano Nicolas
   Llobera, Natalia Daniela
   Ceriani, Florencia
   Gonzalez, Victoria
   Montalvan, Martha
   Verde, Ludovica
   Frias-Toral, Evelyn
TI Obesity and micronutrients deficit, when and how to suplement
SO FOOD AND AGRICULTURAL IMMUNOLOGY
LA English
DT Review
DE Obesity; vitamin D; micronutrients; diet
ID VITAMIN-D SUPPLEMENTATION; SERUM 25-HYDROXYVITAMIN D; HUMAN
   HEPATOMA-CELLS; BODY-WEIGHT STATUS; INSULIN-RESISTANCE; ADIPOSE-TISSUE;
   OXIDATIVE STRESS; IMMUNE-RESPONSE; NUTRITION; HEALTH
AB Since the 1990s the worldwide rate of obesity has escalated significantly. This overflow affects all demographic groups, with a notable impact on older adults and women. Obesity is associated with a variety of serious chronic health conditions. Additionally, it is linked to endocrine disorders such as hypothyroidism and subclinical hypothyroidism. This review analyzes the connection between obesity and micronutrient levels, particularly focusing on vitamin D, and evaluates potential nutritional and supplementation approaches for this population.Micronutrient imbalances in obesity arise from poor dietary intake, increased nutritional needs, altered pharmacokinetics, and absorption difficulties. These imbalances can lead to critical health and metabolic issues. For example, vitamin D deficiency, which is common in individuals with obesity, is associated with decreased calcium absorption and an incremented risk of type 2 diabetes, metabolic syndrome, and various inflammatory conditions such as cancer.Effectively addressing micronutrient deficiencies requires dietary modifications and, when necessary, supplementation. While enhancing nutrition is critical, supplementation often becomes essential to meet the nutritional needs of individuals with obesity, particularly those on restrictive diets or undergoing bariatric surgery. Supplementing micronutrients and vitamin D in patients with obesity can improve health related outcomes. Moreover, dietary patterns like the Mediterranean diet can increase vitamin D levels. This review underlines the crucial role of tailored supplementation strategies and the demand for continued research to ascertain optimal dosing and its implications for health outcomes.
C1 [Chapela, Sebastian Pablo] Univ Buenos Aires, Fac Med, Dept Bioquim Humana, Buenos Aires, DF, Argentina.
   [Chapela, Sebastian Pablo; Llobera, Natalia Daniela] Hosp Britan Buenos Aires, Equipo Soporte Nutr, Buenos Aires, DF, Argentina.
   [Martinuzzi, Andres Luciano Nicolas] Univ Nacl La Plata, La Plata, Argentina.
   [Martinuzzi, Andres Luciano Nicolas] Fresenius Kabi Argentina, Buenos Aires, DF, Argentina.
   [Ceriani, Florencia] Univ Republica, Escuela Nutr, Montevideo, Uruguay.
   [Gonzalez, Victoria] Sanatorio Allende Cordoba, Unidad Soporte Metab & Nutr, Cordoba, Argentina.
   [Gonzalez, Victoria] Univ Catolica Cordoba, Cordoba, Argentina.
   [Montalvan, Martha] Univ Catolica Santiago Guayaquil, Guayaquil, Ecuador.
   [Verde, Ludovica] Univ Naples Federico II, Dept Publ Hlth, Naples, Italy.
   [Frias-Toral, Evelyn] Univ Espiritu Santo, Escuela Med, Samborondon, Ecuador.
   [Martinuzzi, Andres Luciano Nicolas] Univ Comahue, Dept Postgrad, Neuquen, Argentina.
C3 University of Buenos Aires; Hospital Britanico de Buenos Aires; National
   University of La Plata; Universidad de la Republica, Uruguay; Catholic
   University of Cordoba; University of Naples Federico II; Universidad de
   Especialidades Espiritu Santo; Universidad Nacional del Comahue
RP Chapela, SP (corresponding author), Univ Buenos Aires, Fac Med, Dept Bioquim Humana, Buenos Aires, DF, Argentina.; Chapela, SP (corresponding author), Hosp Britan Buenos Aires, Equipo Soporte Nutr, Buenos Aires, DF, Argentina.
EM sebachapela@gmail.com
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NR 144
TC 10
Z9 10
U1 4
U2 15
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0954-0105
EI 1465-3443
J9 FOOD AGR IMMUNOL
JI Food Agric. Immunol.
PD DEC 31
PY 2024
VL 35
IS 1
AR 2381725
DI 10.1080/09540105.2024.2381725
PG 25
WC Chemistry, Applied; Food Science & Technology; Immunology; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Food Science & Technology; Immunology; Toxicology
GA A5S1S
UT WOS:001283117600001
OA gold
DA 2025-06-11
ER

PT J
AU Bali, AD
   Rosenzveig, A
   Frishman, WH
   Aronow, WS
AF Bali, Atul D.
   Rosenzveig, Akiva
   Frishman, William H.
   Aronow, Wilbert S.
TI Nonalcoholic Fatty Liver Disease and Cardiovascular Disease: Causation
   or Association
SO CARDIOLOGY IN REVIEW
LA English
DT Review
DE nonalcoholic fatty liver disease; nonalcoholic hepatic steatosis;
   cardiovascular disease
ID PROLIFERATOR-ACTIVATED RECEPTOR; CORONARY-ARTERY CALCIFICATION;
   INSULIN-RESISTANCE; HEPATIC STEATOSIS; HEART-DISEASE; ALANINE
   AMINOTRANSFERASE; ENDOTHELIAL DYSFUNCTION; DEPENDENT REDUCTIONS;
   OBETICHOLIC ACID; QTC INTERVAL
AB Nonalcoholic fatty liver disease (NAFLD) is a disease process that is gaining increasing recognition. The global prevalence of NAFLD is increasing in parallel with growing rates of risk factors for NAFLD such as hypertension, obesity, diabetes, and metabolic syndrome. NAFLD has been referred to as a risk factor for cardiovascular disease (CVD). As CVD is the leading cause of morbidity and mortality worldwide, there are constant efforts to describe and alleviate its risk factors. Although there is conflicting data supporting NAFLD as a causative or associative factor for CVD, NAFLD has been shown to be associated with structural, electrical, and atherosclerotic disease processes of the heart. Shared risk factors and pathophysiologic mechanisms between NAFLD and CVD warrant further explication. Pathologic mechanisms such as endothelial dysfunction, oxidative stress, insulin resistance, genetic underpinnings, and gut microbiota dysregulation have been described in both CVD and NAFLD. The mainstay of treatment for NAFLD is lifestyle intervention including physical exercise and hypocaloric intake in addition to bariatric surgery. Investigations into various therapeutic targets to alleviate hepatic steatosis and fibrosis by way of maintaining the balance between lipid synthesis and breakdown. A major obstacle preventing the success of many pharmacologic approaches has been the effects of these medications on CVD risk. The future of pharmacologic treatment of NAFLD is promising as effective medications with limited CVD harm are being investigated.
C1 [Bali, Atul D.; Frishman, William H.; Aronow, Wilbert S.] Westchester Med Ctr, Dept Cardiol, Macy Pavil,Room 141, Valhalla, NY 10595 USA.
   [Bali, Atul D.; Rosenzveig, Akiva; Frishman, William H.; Aronow, Wilbert S.] New York Med Coll, Valhalla, NY USA.
C3 Westchester Medical Center; New York Medical College
RP Aronow, WS (corresponding author), Westchester Med Ctr, Dept Cardiol, Macy Pavil,Room 141, Valhalla, NY 10595 USA.; Aronow, WS (corresponding author), New York Med Coll, Med, Macy Pavil,Room 141, Valhalla, NY 10595 USA.
EM wsaronow@aol.com
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NR 161
TC 7
Z9 7
U1 3
U2 9
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1061-5377
EI 1538-4683
J9 CARDIOL REV
JI Cardiol. Rev.
PD SEP-OCT
PY 2024
VL 32
IS 5
BP 453
EP 462
DI 10.1097/CRD.0000000000000537
PG 10
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA A6M0D
UT WOS:001283644100007
PM 36825899
DA 2025-06-11
ER

PT J
AU Liu, ZY
   Li, YF
   Yu, CH
AF Liu, Ziyu
   Li, Yufei
   Yu, Caihong
TI Identification of the Non-Alcoholic Fatty Liver Disease Molecular
   Subtypes Associated With Clinical and Immunological Features via
   Bioinformatics Methods
SO FRONTIERS IN IMMUNOLOGY
LA English
DT Article
DE molecular subtypes; bioinformatics; non-alcoholic fatty liver disease;
   inflammation; immune cell infiltration
ID DIABETES-MELLITUS; GENE-EXPRESSION; STEATOHEPATITIS; SIGNATURES;
   EFFICACY; STRESS; SAFETY; N-3
AB BackgroundNon-alcoholic fatty liver disease (NAFLD) is a manifestation of metabolic syndrome in the liver with varying severity. Heterogeneity in terms of molecules and immune cell infiltration drives NAFLD from one stage to the next. However, a precise molecular classification of NAFLD is still lacking, and the effects of complex clinical phenotypes on the efficacy of drugs are usually ignored. MethodsWe introduced multiple omics data to differentiate NAFLD subtypes via consensus clustering, and a weighted gene co-expression network analysis was used to identify eight co-expression modules. Further, eigengenes of eight modules were analyzed with regard to Gene Ontology enrichment and Kyoto Encyclopedia of Genes and Genomes pathways. Furthermore, the infiltration rates of 22 immune cell types were calculated with CIBERSORT and the ESTIMATE algorithm. ResultsIn total, 111 NAFLD patients from three independent GEO datasets were divided into four molecular subtypes, and the corresponding clinical features and immune cell infiltration traits were determined. Based on high gene expression correlations, four molecular subtypes were further divided into eight co-expression modules. We also demonstrated a significant correlation between gene modules and clinical phenotypes. Moreover, we integrated phenotypic, immunologic, and genetic data to assess the potential for progression of different molecular subtypes. Furthermore, the efficacy of drugs against various NAFLD molecular subtypes was discussed to aid in individualized therapy. ConclusionOverall, this study could provide new insights into the underlying pathogenesis of and drug targets for NAFLD.
C1 [Liu, Ziyu; Li, Yufei; Yu, Caihong] Hunan Normal Univ, Sch Med, Changsha, Peoples R China.
C3 Hunan Normal University
RP Li, YF; Yu, CH (corresponding author), Hunan Normal Univ, Sch Med, Changsha, Peoples R China.
EM liyufei666@163.com; Caihongyu23@126.com
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TC 5
Z9 5
U1 0
U2 9
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-3224
J9 FRONT IMMUNOL
JI Front. Immunol.
PD JUL 25
PY 2022
VL 13
AR 857892
DI 10.3389/fimmu.2022.857892
PG 15
WC Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology
GA 3Q2XI
UT WOS:000838097000001
PM 35958576
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU La Valle, A
   Crocco, M
   Chiarenza, DS
   Maghnie, M
   d'Annunzio, G
AF La Valle, Alberto
   Crocco, Marco
   Chiarenza, Decimo Silvio
   Maghnie, Mohamad
   d'Annunzio, Giuseppe
TI Endothelial impairment evaluation by peripheral arterial tonometry in
   pediatric endocrinopathies: A narrative review
SO WORLD JOURNAL OF DIABETES
LA English
DT Review
DE Pediatric diabetes mellitus; Pediatric endocrinopathies; Metabolic
   syndrome; Cancer survivors; Endothelial dysfunction; Peripheral artery
   tonometry
ID CARDIOVASCULAR RISK-FACTORS; CHILDHOOD-CANCER SURVIVORS; LONG-TERM
   SURVIVORS; FATTY LIVER-DISEASE; OXIDATIVE STRESS; CORONARY-ARTERIES;
   PROGENITOR CELLS; VASCULAR HEALTH; ADOLESCENTS; CHILDREN
AB Endothelial dysfunction (ED) is characterized by an imbalance between vasodilator and vasoconstriction agents. Several pathological conditions clinically diagnosed in childhood and adolescence are characterized by ED and increased risk for early development of microangiopathic and macroangiopathic impairment, in particular type 1 diabetes mellitus (T1DM), T2DM, obesity, metabolic syndromeand pituitary dysfunction associated to various endocrinopathies. More recently insulin resistance following chemotherapy or radiotherapy for tumors, bone marrow transplantation for hematological malignancies (i.e., cancer survivors), or immunosuppressive treatment for solid organ transplantation has been observed. Assessment of ED by means of non-invasive techniques is the gold standard for early ED detection before clinical manifestation. It is aimed to recognize patients at risk and to avoid the development and progression of more serious illnesses. Reactive hyperemia-peripheral artery tonometry is a noninvasive technique to assess peripheral endothelial function by measuring modifications in digital pulse volume during reactive hyperemia, and represents a non-invasive, reproducible and operator-independent tool able to detect precocious ED. This narrative review aimed to provide an overview of the most important papers regarding ED detection by EndoPat 2000 in children and adolescents with different endocrine diseases. A comprehensive search of English language articles was performed in the MEDLINE database without using other search filters except the publication interval between 2005 and 2020.
C1 [La Valle, Alberto; Crocco, Marco; Chiarenza, Decimo Silvio; Maghnie, Mohamad; d'Annunzio, Giuseppe] IRCCS Ist Giannina Gaslini, Pediat Clin & Endocrinol, Via Gaslini 5, I-16147 Genoa, Italy.
   [La Valle, Alberto; Crocco, Marco; Chiarenza, Decimo Silvio; Maghnie, Mohamad] Univ Genoa, IRCCS Giannina Gaslini Inst, Dept Neurosci Rehabil Ophthalmol, Pediat Clin & Endocrinol, I-16147 Genoa, Italy.
C3 University of Genoa; IRCCS Istituto Giannina Gaslini; University of
   Genoa; IRCCS Istituto Giannina Gaslini
RP d'Annunzio, G (corresponding author), IRCCS Ist Giannina Gaslini, Pediat Clin & Endocrinol, Via Gaslini 5, I-16147 Genoa, Italy.
EM giuseppedannunzio@gaslini.org
RI d'Annunzio, Giuseppe/J-7368-2018; Maghnie, Marwa/AAE-5311-2022; Crocco,
   Marco/AAC-2498-2019
OI Crocco, Marco/0000-0001-7277-4767; Chiarenza, Decimo
   Silvio/0000-0002-6877-9511
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NR 94
TC 4
Z9 4
U1 0
U2 7
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 7041 Koll Center Parkway, Suite 160, PLEASANTON, CA, UNITED STATES
EI 1948-9358
J9 WORLD J DIABETES
JI World J. Diabetes
PD JUN 15
PY 2021
VL 12
IS 6
DI 10.4239/wjd.v12.i6.810
PG 18
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA SU4BX
UT WOS:000663086300009
PM 34168730
OA gold, Green Published
DA 2025-06-11
ER

EF﻿FN Clarivate Analytics Web of Science
VR 1.0
PT J
AU Di Ciaula, A
   Baj, J
   Garruti, G
   Celano, G
   De Angelis, M
   Wang, HH
   Di Palo, DM
   Bonfrate, L
   Wang, DQH
   Portincasa, P
AF Di Ciaula, Agostino
   Baj, Jacek
   Garruti, Gabriella
   Celano, Giuseppe
   De Angelis, Maria
   Wang, Helen H.
   Di Palo, Domenica Maria
   Bonfrate, Leonilde
   Wang, David Q-H
   Portincasa, Piero
TI Liver Steatosis, Gut-Liver Axis, Microbiome and Environmental Factors. A
   Never-Ending Bidirectional Cross-Talk
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Review
DE body weight; fat; fatty liver; genetics; intestinal permeability; leaky
   gut; NAFLD
ID INTESTINAL BACTERIAL OVERGROWTH; HIGH-FAT DIET;
   LIPOPOLYSACCHARIDE-BINDING PROTEIN; TOTAL PARENTERAL-NUTRITION;
   NON-ALCOHOLIC STEATOHEPATITIS; JUNCTIONAL ADHESION MOLECULE; HEPATIC
   STELLATE CELLS; NECROSIS-FACTOR-ALPHA; BILE-ACID METABOLISM; OXIDATIVE
   STRESS
AB The prevalence of non-alcoholic fatty liver disease (NAFLD) is increasing worldwide and parallels comorbidities such as obesity, metabolic syndrome, dyslipidemia, and diabetes. Recent studies describe the presence of NAFLD in non-obese individuals, with mechanisms partially independent from excessive caloric intake. Increasing evidences, in particular, point towards a close interaction between dietary and environmental factors (including food contaminants), gut, blood flow, and liver metabolism, with pathways involving intestinal permeability, the composition of gut microbiota, bacterial products, immunity, local, and systemic inflammation. These factors play a critical role in the maintenance of intestinal, liver, and metabolic homeostasis. An anomalous or imbalanced gut microbial composition may favor an increased intestinal permeability, predisposing to portal translocation of microorganisms, microbial products, and cell wall components. These components form microbial-associated molecular patterns (MAMPs) or pathogen-associated molecular patterns (PAMPs), with potentials to interact in the intestine lamina propria enriched in immune cells, and in the liver at the level of the immune cells, i.e., Kupffer cells and stellate cells. The resulting inflammatory environment ultimately leads to liver fibrosis with potentials to progression towards necrotic and fibrotic changes, cirrhosis. and hepatocellular carcinoma. By contrast, measures able to modulate the composition of gut microbiota and to preserve gut vascular barrier might prevent or reverse NAFLD.
C1 [Di Ciaula, Agostino; Di Palo, Domenica Maria; Bonfrate, Leonilde; Portincasa, Piero] Univ Bari, Dept Biomed Sci & Human Oncol, Clin Med A Murri, Med Sch, I-70124 Bari, Italy.
   [Baj, Jacek] Med Univ Lublin, Dept Anat, PL-20090 Lublin, Poland.
   [Garruti, Gabriella] Univ Bari Aldo Moro, Sect Endocrinol, Dept Emergency & Organ Transplantat, Med Sch, Piazza G Cesare 11, I-70124 Bari, Italy.
   [Celano, Giuseppe; De Angelis, Maria; Di Palo, Domenica Maria] Univ Bari Aldo Moro, Dipartimento Sci Suolo Pianta & Alimenti, I-70124 Bari, Italy.
   [Wang, Helen H.; Wang, David Q-H] Albert Einstein Coll Med, Mar Bessin Liver Res Ctr, Einstein Mt Sinai Diabet Res Ctr, Dept Med & Genet,Div Gastroenterol & Liver Dis, Bronx, NY 10461 USA.
C3 Universita degli Studi di Bari Aldo Moro; Medical University of Lublin;
   Universita degli Studi di Bari Aldo Moro; Universita degli Studi di Bari
   Aldo Moro; Yeshiva University; Montefiore Medical Center; Albert
   Einstein College of Medicine
RP Portincasa, P (corresponding author), Univ Bari, Dept Biomed Sci & Human Oncol, Clin Med A Murri, Med Sch, I-70124 Bari, Italy.
EM agostinodiciaula@tiscali.it; jacek.baj@me.com;
   gabriella.garruti@uniba.it; g.celano1@gmail.com;
   domenicamariadipalo@gmail.com; helen.wang@einsteinmed.org;
   maria.deangelis@uniba.it; leonildebnf@gmail.com;
   david.wang@einsteinmed.org; piero.portincasa@uniba.it
RI Baj, Jacek/AAR-4412-2020; De Angelis, Maria/AAA-9909-2019; wang,
   David/KFR-2555-2024; Bonfrate, Leonilde/ABH-1835-2021; portincasa,
   piero/J-7245-2018; celano, giuseppe/GSO-3402-2022; Di Ciaula,
   Agostino/AAW-3499-2021; Di Ciaula, Agostino/M-4300-2017
OI De Angelis, Maria/0000-0002-2010-884X; Celano,
   Giuseppe/0000-0002-3805-7681; portincasa, piero/0000-0001-5359-1471;
   Baj, Jacek/0000-0002-1372-8987; Di Ciaula, Agostino/0000-0002-5476-7376
FU European Union [722619]
FX The present chapter is written in the context of the project FOIE GRAS,
   which has received funding from the European Union's Horizon 2020
   Research and Innovation program under the Marie Sklodowska-Curie Grant
   Agreement No. 722619.
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NR 409
TC 101
Z9 103
U1 1
U2 25
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD AUG
PY 2020
VL 9
IS 8
AR 2648
DI 10.3390/jcm9082648
PG 44
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA NH6LL
UT WOS:000564779700001
PM 32823983
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Amput, P
   Palee, S
   Arunsak, B
   Pratchayasakul, W
   Thonusin, C
   Kerdphoo, S
   Jaiwongkam, T
   Chattipakorn, SC
   Chattipakorn, N
AF Amput, Patchareeya
   Palee, Siripong
   Arunsak, Busarin
   Pratchayasakul, Wasana
   Thonusin, Chanisa
   Kerdphoo, Sasiwan
   Jaiwongkam, Thidarat
   Chattipakorn, Siriporn C.
   Chattipakorn, Nipon
TI PCSK9 inhibitor and atorvastatin reduce cardiac impairment in
   ovariectomized prediabetic rats via improved mitochondrial function and
   Ca<SUP>2+</SUP>regulation
SO JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
LA English
DT Article
DE atorvastatin; heart; insulin resistance; obesity; oestrogen deprivation;
   PCSK9 inhibitor
ID OBESE-INSULIN-RESISTANT; SUBTILISIN/KEXIN TYPE 9;
   HEART-RATE-VARIABILITY; CYTOCHROME-C RELEASE; CARDIOVASCULAR-DISEASE;
   MONOCLONAL-ANTIBODY; METABOLIC SYNDROME; OXIDATIVE STRESS; ESTROGEN;
   EFFICACY
AB Post-menopausal women have a higher risk of developing cardiometabolic dysfunction. Atorvastatin attenuates dyslipidaemia and cardiac dysfunction but it can have undesirable effects including increased risk of diabetes and myalgia. Currently, the proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor efficiently reduces low-density lipoprotein cholesterol (LDL-C) levels more effectively than atorvastatin. We have been suggested that PCSK9 inhibitor attenuated cardiometabolic impairment more effectively than atorvastatin in ovariectomized prediabetic rats. Female Wistar rats (n = 48) were fed a normal diet (ND) or high-fat diet (HFD) for 12 weeks. Then, HFD rats were assigned to a sham-operated (Sham) or ovariectomized (OVX) group. Six weeks after surgery, the OVX group was subdivided into 4 treatment groups: vehicle (HFOV), atorvastatin (HFOA) (40 mg/kg/day; s.c.), PCSK9 inhibitor (HFOP) (4 mg/kg/day; s.c.) and oestrogen (HFOE2) (50 mu g/kg/day; s.c.) for an additional 3 weeks. Metabolic parameters, cardiac and mitochondrial function, and [Ca2+](i)transients were evaluated. All HFD rats became obese-insulin resistant. HFS rats had significantly impaired left ventricular (LV) function, cardiac mitochondrial function and [Ca2+](i)transient dysregulation. Oestrogen deprivation (HFOV) aggravated all of these impairments. Our findings indicated that the atorvastatin, PCSK9 inhibitor and oestrogen shared similar efficacy in the attenuation in cardiometabolic impairment in ovariectomized prediabetic rats.
C1 [Amput, Patchareeya; Palee, Siripong; Arunsak, Busarin; Pratchayasakul, Wasana; Thonusin, Chanisa; Kerdphoo, Sasiwan; Jaiwongkam, Thidarat; Chattipakorn, Siriporn C.; Chattipakorn, Nipon] Chiang Mai Univ, Fac Med, Cardiac Electrophysiol Res & Training Ctr, Chiang Mai 50200, Thailand.
   [Amput, Patchareeya; Arunsak, Busarin; Pratchayasakul, Wasana; Thonusin, Chanisa; Chattipakorn, Nipon] Chiang Mai Univ, Fac Med, Dept Physiol, Cardiac Electrophysiol Unit, Chiang Mai, Thailand.
   [Amput, Patchareeya; Palee, Siripong; Arunsak, Busarin; Pratchayasakul, Wasana; Thonusin, Chanisa; Kerdphoo, Sasiwan; Jaiwongkam, Thidarat; Chattipakorn, Siriporn C.; Chattipakorn, Nipon] Chiang Mai Univ, Ctr Excellence Cardiac Electrophysiol Res, Chiang Mai, Thailand.
   [Amput, Patchareeya] Univ Phayao, Fac Allied Hlth Sci, Dept Phys Therapy, Phayao, Thailand.
C3 Chiang Mai University; Chiang Mai University; Chiang Mai University;
   University of Phayao
RP Chattipakorn, N (corresponding author), Chiang Mai Univ, Fac Med, Cardiac Electrophysiol Res & Training Ctr, Chiang Mai 50200, Thailand.
EM nchattip@gmail.com
RI PALEE, SIRIPONG/ABD-8607-2021; Chattipakorn, Nipon/AAJ-4049-2021
OI Chattipakorn, Siriporn/0000-0003-1677-7052; Clements, Thomas
   W/0000-0002-0278-5660; Chattipakorn, Nipon/0000-0003-3026-718X
FU National Science and Technology Development Agency Thailand; Thailand
   Research Fund [RSA6180056, RSA6180071, MRG6280014]; Chiang Mai
   University Center of Excellence Award; National Research Council of
   Thailand
FX The NSTDA Research Chair grant from the National Science and Technology
   Development Agency Thailand (NC), the Senior Research Scholar grant from
   the National Research Council of Thailand (SCC), Thailand Research Fund
   grants RSA6180056 (SP), RSA6180071 (WP), MRG6280014 (CT); and the Chiang
   Mai University Center of Excellence Award (NC).
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NR 58
TC 10
Z9 12
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1582-1838
EI 1582-4934
J9 J CELL MOL MED
JI J. Cell. Mol. Med.
PD AUG
PY 2020
VL 24
IS 16
BP 9189
EP 9203
DI 10.1111/jcmm.15556
EA JUL 2020
PG 15
WC Cell Biology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Research & Experimental Medicine
GA MX6GY
UT WOS:000549728000001
PM 32628813
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Okamura, T
   Hashimoto, Y
   Hamaguchi, M
   Obora, A
   Kojima, T
   Fukui, M
AF Okamura, Takuro
   Hashimoto, Yoshitaka
   Hamaguchi, Masahide
   Obora, Akihiro
   Kojima, Takao
   Fukui, Michiaki
TI Visceral Adiposity Index is a predictor of incident colorectal cancer: a
   population-based longitudinal study
SO BMJ OPEN GASTROENTEROLOGY
LA English
DT Article
ID NECROSIS-FACTOR-ALPHA; METABOLIC SYNDROME; INSULIN-RESISTANCE; OXIDATIVE
   STRESS; FAT ACCUMULATION; RISK; OBESITY; ASSOCIATION; ADIPONECTIN; MEN
AB Objective The Visceral Adiposity Index (VAI) is a marker of visceral fat accumulation and dysfunction. We aimed to investigate the association between VAI and incident colorectal cancer (CRC).
   Design In this historical cohort study of 27 921 (16 434 men and 11 487 women) participants, we divided the participants into tertiles according to VAI. We calculated VAI: men, VAI = (waist circumference (WC)/(39.68+1.88 x body mass index (BMI))) x (triglycerides (TG)/1.03) x (1.31/high-density lipoprotein cholesterol (HDL)); women, VAI = (WC/(36.58+1.89 x BMI)) x (TG/0.81) x (1.52/HDL). We performed Cox proportional hazard models, adjusting for sex, age, smoking, alcohol consumption, exercise, haemoglobin A1c and systolic blood pressure.
   Results During the median 4.4-year follow-up, 116 participants developed CRC. Compared with the lowest tertile, the HRs of incident CRC in the middle and the highest tertiles were 1.30 (95% Cl 0.76 to 2.28, p=0.338) and 2.41 (1.50 to 4.02, p<0.001) in univariate analysis. Moreover, the HRs of incident CRC in the middle and the highest tertiles were 1.27 (0.73 to 2.23, p=0.396) and 1.98 (1.15 to 3.39, p=0.013) after adjusting for covariates.
   Conclusions VAI can be a predictor of incident CRC. For early detection, we should encourage people with high VAI to undergo screening for CRC.
C1 [Okamura, Takuro; Hashimoto, Yoshitaka; Hamaguchi, Masahide; Fukui, Michiaki] Kyoto Prefectural Univ Med, Grad Sch Med Sci, Dept Endocrinol & Metab, Kyoto, Japan.
   [Obora, Akihiro; Kojima, Takao] Asahi Univ Hosp, Dept Gastroenterol, Gifu, Japan.
C3 Kyoto Prefectural University of Medicine; Asahi University
RP Hamaguchi, M (corresponding author), Kyoto Prefectural Univ Med, Grad Sch Med Sci, Dept Endocrinol & Metab, Kyoto, Japan.
EM mhama@koto.kpu-m.ac.jp
RI Okamura, Takuro/AAP-3050-2020; Hashimoto, Yoshitaka/AAH-8503-2020
OI Hamaguchi, Masahide/0000-0002-8651-4445; Hashimoto,
   Yoshitaka/0000-0002-8794-0550; Okamura, Takuro/0000-0001-7269-1697
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NR 46
TC 7
Z9 7
U1 0
U2 1
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2054-4774
J9 BMJ OPEN GASTROENTER
JI BMJ Open Gastroenterol.
PY 2020
VL 7
IS 1
AR e000400
DI 10.1136/bmjgast-2020-000400
PG 7
WC Gastroenterology & Hepatology
WE Emerging Sources Citation Index (ESCI)
SC Gastroenterology & Hepatology
GA MH7RY
UT WOS:000546922600002
PM 32595114
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Poonit, ND
   Cai, XH
AF Poonit, Neha Devi
   Cai, Xiao Hong
TI The relation and mechanism of kidney injury in obstructive sleep apnea:
   a literature review
SO SLEEP AND BIOLOGICAL RHYTHMS
LA English
DT Review
DE Obstructive sleep apnea syndrome; Kidney injury; Sympathetic autonomic
   nervous system; Renin-angiotensin-aldosterone system; Endothelial
   dysfunction; Atrial natriuretic peptide
ID POSITIVE AIRWAY PRESSURE; STAGE RENAL-DISEASE; RENIN-ANGIOTENSIN SYSTEM;
   ATRIAL-NATRIURETIC-PEPTIDE; URINARY ALBUMIN EXCRETION; ENDOTHELIAL
   GROWTH-FACTOR; CHRONIC EPISODIC HYPOXIA; INTERMITTENT HYPOXIA;
   BLOOD-PRESSURE; OXIDATIVE STRESS
AB Up to date, it is found that the presence of obstructive sleep apnea (OSA) contributes to the development of structural, ultra-structural, functional, and proteomics changes in the kidney. These changes are based on pathological processes, such as increased production of free radicals, disruption of mediated NO vasodilation reactions, activation of the sympathetic autonomic nervous system, the renin-angiotensin-aldosterone system, dysfunction of endothelium, the development of renal venous hypertension, and stimulation of atrial natriuretic peptide production. All this in turn contributes to an increase in intra-glomerular pressure, the occurrence of glomerular hyperfiltration, nocturnal polyuria, renal functional changes, proteinuria and renal tubular dysfunction. Kidney injury in OSA patients can also be caused by pathological conditions associated with OSA, such as cor pulmonale, erythrocytosis, diabetes mellitus, metabolic syndrome, hypertension, coronary heart diseases, and atherosclerosis, which in isolated conditions can lead to development of kidney damage, and co-occurring with OSA can even aggravate the course of the latter. There is a bidirectional relationship between kidney diseases and OSA through a number of potential pathological mechanisms, which suggests the possibility of both diseases to be a possible risk factor for each other. Moreover, kidney diseases may lead to OSA through a multifarious of mechanisms, including chemoreflex responsiveness, pharyngeal narrowing due to fluid overload, and accumulation of uremic toxins.
C1 [Poonit, Neha Devi; Cai, Xiao Hong] Wenzhou Med Univ, Affiliated Hosp 2, Dept Pediat, 109 Xueyuan Western Rd, Wenzhou 325027, Zhejiang, Peoples R China.
   [Poonit, Neha Devi; Cai, Xiao Hong] Wenzhou Med Univ, Yuying Childrens Hosp, 109 Xueyuan Western Rd, Wenzhou 325027, Zhejiang, Peoples R China.
   [Poonit, Neha Devi; Cai, Xiao Hong] Wenzhou Med Univ, Sch Med 2, Wenzhou, Zhejiang, Peoples R China.
C3 Wenzhou Medical University; Wenzhou Medical University; Wenzhou Medical
   University
RP Cai, XH (corresponding author), Wenzhou Med Univ, Affiliated Hosp 2, Dept Pediat, 109 Xueyuan Western Rd, Wenzhou 325027, Zhejiang, Peoples R China.; Cai, XH (corresponding author), Wenzhou Med Univ, Yuying Childrens Hosp, 109 Xueyuan Western Rd, Wenzhou 325027, Zhejiang, Peoples R China.; Cai, XH (corresponding author), Wenzhou Med Univ, Sch Med 2, Wenzhou, Zhejiang, Peoples R China.
EM caixh839@sina.com
FU Zhejiang Provincial Natural Science Foundation [LY17H010004]; Scientific
   Research Foundation of Health Bureau of Zhejiang Province [2018ZD010];
   Wenzhou City Science and Technology Bureau Grant [Y20170133]; National
   Science-technology Support Program [2015BAI12B09]; Project of Key
   Innovative Disciplines of Children Sleep Medicine of Zhejiang
FX This work was supported by Zhejiang Provincial Natural Science
   Foundation Grant (LY17H010004), Scientific Research Foundation of Health
   Bureau of Zhejiang Province (2018ZD010), Wenzhou City Science and
   Technology Bureau Grant (Y20170133), National Science-technology Support
   Program (2015BAI12B09), and Project of Key Innovative Disciplines of
   Children Sleep Medicine of Zhejiang.
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NR 126
TC 3
Z9 3
U1 0
U2 13
PU SPRINGER LONDON LTD
PI LONDON
PA 236 GRAYS INN RD, 6TH FLOOR, LONDON WC1X 8HL, ENGLAND
SN 1446-9235
EI 1479-8425
J9 SLEEP BIOL RHYTHMS
JI Sleep Biol. Rhythms
PD APR
PY 2018
VL 16
IS 2
BP 151
EP 167
DI 10.1007/s41105-018-0146-x
PG 17
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA GB5MJ
UT WOS:000429108300002
DA 2025-06-11
ER

PT J
AU Heath, G
   Coates, A
   Sargent, C
   Dorrian, J
AF Heath, Georgina
   Coates, Alison
   Sargent, Charli
   Dorrian, Jillian
TI Sleep Duration and Chronic Fatigue Are Differently Associated with the
   Dietary Profile of Shift Workers
SO NUTRIENTS
LA English
DT Article
DE shift work; shift schedule; sleep duration; fatigue; diet; energy
   intake; macronutrient distribution; dietary profile
ID BODY-MASS INDEX; ENERGY-INTAKE; NUTRITIONAL-STATUS; METABOLIC SYNDROME;
   EATING HABITS; FOOD RECORDS; LIFE-STYLE; HEALTH; CONSUMPTION; STRESS
AB Shift work has been associated with dietary changes. This study examined factors associated with the dietary profiles of shift workers from several industries (n = 118, 57 male; age = 43.4 +/- 9.9 years) employed on permanent mornings, nights, or rotating 8-h or 12-h shifts. The dietary profile was assessed using a Food Frequency Questionnaire. Shift-related (e.g., sleep duration and fatigue), work-related (e.g., industry), and demographic factors (e.g., BMI) were measured using a modified version of the Standard Shift work Index. Mean daily energy intake was 8628 +/- 3161 kJ. As a percentage of daily energy intake, all workers reported lower than recommended levels of carbohydrate (CHO, 45%-65%). Protein was within recommended levels (15%-25%). Permanent night workers were the only group to report higher than recommended fat intake (20%-35%). However, all workers reported higher than recommended levels of saturated fat (>10%) with those on permanent nights reporting significantly higher levels than other groups (Mean = 15.5% +/- 3.1%, p < 0.05). Shorter sleep durations and decreased fatigue were associated with higher CHO intake (p <= 0.05) whereas increased fatigue and longer sleep durations were associated with higher intake of fat (p <= 0.05). Findings demonstrate sleep duration, fatigue, and shift schedule are associated with the dietary profile of shift workers.
C1 [Heath, Georgina; Dorrian, Jillian] Univ South Australia, Ctr Sleep Res, Adelaide, SA 5000, Australia.
   [Coates, Alison] Univ South Australia, Alliance Res Exercise, Nutr & Act, Adelaide, SA 5000, Australia.
   [Sargent, Charli] Cent Queensland Univ, Appleton Inst Behav Sci, Wayville 5034, Australia.
C3 University of South Australia; University of South Australia; Central
   Queensland University
RP Heath, G (corresponding author), Univ South Australia, Ctr Sleep Res, Adelaide, SA 5000, Australia.
EM Georgina.heath@unisa.edu.au; alison.coates@unisa.edu.au;
   charli.sargent@cqu.edu.au; jill.dorrian@unisa.edu.au
RI Sargent, Charli/U-7393-2019; Coates, Alison/A-3988-2009; Dorrian,
   Jillian/C-1339-2010
OI Coates, Alison/0000-0003-1031-2545; Heath, Georgina/0000-0002-9280-2398;
   Dorrian, Jillian/0000-0002-6485-1643; Sargent,
   Charli/0000-0001-5340-4701
FU Australian Post Graduate Award
FX We would like to thank all participants and industry representatives who
   helped make this research possible. G.H. was funded with an Australian
   Post Graduate Award; otherwise; this research received no specific grant
   from any funding agency, commercial or not-for-profit sectors.
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NR 72
TC 34
Z9 36
U1 0
U2 24
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD DEC
PY 2016
VL 8
IS 12
AR 771
DI 10.3390/nu8120771
PG 15
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nutrition & Dietetics
GA ED8TP
UT WOS:000389144100021
PM 27916861
OA gold, Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Li, XL
   Li, WL
   Gao, ZH
   Li, HL
AF Li, Xueli
   Li, Wenliang
   Gao, Zhonghong
   Li, Hailing
TI Association of cardiac injury with iron-increased oxidative and
   nitrative modifications of the SERCA2a isoform of sarcoplasmic reticulum
   Ca<SUP>2+</SUP>-ATPase in diabetic rats
SO BIOCHIMIE
LA English
DT Article
DE Iron; Diabetic heart complications; Tyrosine nitration; SERCA2a
ID NITRIC-OXIDE SYNTHASE; PROTEIN-TYROSINE NITRATION;
   CORONARY-HEART-DISEASE; NITROSATIVE STRESS; CONTRACTILE DYSFUNCTION;
   METABOLIC SYNDROME; PEROXYNITRITE; FAILURE; CARDIOMYOPATHY; DAMAGE
AB The role of iron in the etiology of diabetes complications is not well established. Thus, this study was performed to test whether the iron-induced increase of oxidative/nitrative damage is involved in SERCA2a-related diabetic heart complication. Four randomly divided groups of rats were used: normal control group; iron overload group; diabetes group, and diabetic plus iron overload group. Iron supplementation stimulated cardiomyocyte hypertrophy and led to an increase in cardiac protein carbonyls, nitrotyrosine (3-NT) formation, and iNOS protein expression, thus resulting in abnormal myocardium calcium homeostasis of diabetic rats. The levels of SECA2a oxidation/nitration were significantly increased in the iron overload diabetic rats, along with a decrease in SECA2a expression and activity. In order to elucidate the possible role of iron in SERCA2a dysfunction, the effects of iron (Fe3+ or hemin) on peroxynitrite (ONOO-) induced SERCA2a oxidation and nitration were further investigated in vitro. It was found that tyrosine nitration played more important role in SERCA2a inactivation than thiol oxidation. These results present a potential mechanism in which iron exacerbates the diabetes-induced oxidative/nitrative modification of SERCA2a, which may cause functional deficits in the myocyte associated with diabetic cardiac dysfunction. Our findings may help to further understand the role of iron in the pathogenesis of diabetic complications. (C) 2016 Elsevier B.V. and Societe Francaise de Biochimie et Biologie Moleculaire (SFBBM). All rights reserved.
C1 [Li, Xueli; Li, Wenliang; Gao, Zhonghong; Li, Hailing] Huazhong Univ Sci & Technol, Sch Chem & Chem Engn, Wuhan 430074, Peoples R China.
   [Li, Xueli] SIPO, Patent Examinat Cooperat Hubei Ctr, Patent Off, Wuhan 430070, Peoples R China.
   [Gao, Zhonghong; Li, Hailing] Hubei Key Lab Bioinorgan Chem & Mat Med, Wuhan 430074, Peoples R China.
C3 Huazhong University of Science & Technology
RP Li, HL (corresponding author), Huazhong Univ Sci & Technol, Sch Chem & Chem Engn, Wuhan 430074, Peoples R China.
EM lihailing86@hust.edu.cn
RI Li, Wenliang/F-2907-2014
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NR 64
TC 20
Z9 21
U1 0
U2 26
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0300-9084
EI 1638-6183
J9 BIOCHIMIE
JI Biochimie
PD AUG
PY 2016
VL 127
BP 144
EP 152
DI 10.1016/j.biochi.2016.05.011
PG 9
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA DR7LZ
UT WOS:000380082500017
PM 27222135
DA 2025-06-11
ER

PT J
AU Nawata, A
   Noguchi, H
   Mazaki, Y
   Kurahashi, T
   Izumi, H
   Wang, KY
   Guo, X
   Uramoto, H
   Kohno, K
   Taniguchi, H
   Tanaka, Y
   Fujii, J
   Sasaguri, Y
   Tanimoto, A
   Nakayama, T
   Yamada, S
AF Nawata, Aya
   Noguchi, Hirotsugu
   Mazaki, Yuichi
   Kurahashi, Toshihiro
   Izumi, Hiroto
   Wang, Ke-Yong
   Guo, Xin
   Uramoto, Hidetaka
   Kohno, Kimitoshi
   Taniguchi, Hatsumi
   Tanaka, Yoshiya
   Fujii, Junichi
   Sasaguri, Yasuyuki
   Tanimoto, Akihide
   Nakayama, Toshiyuki
   Yamada, Sohsuke
TI Overexpression of Peroxiredoxin 4 Affects Intestinal Function in a
   Dietary Mouse Model of Nonalcoholic Fatty Liver Disease
SO PLOS ONE
LA English
DT Article
ID METABOLIC SYNDROME; SIGNALING PATHWAY; GENE-EXPRESSION; LXR-ALPHA;
   STEATOHEPATITIS; MICE; CHOLESTEROL; APOPTOSIS; RECEPTOR; MECHANISMS
AB Background
   Accumulating evidence has shown that methionine- and choline-deficient high fat (MCD+HF) diet induces the development of nonalcoholic fatty liver disease (NAFLD), in which elevated reactive oxygen species play a crucial role. We have reported that peroxiredoxin 4 (PRDX4), a unique secretory member of the PRDX antioxidant family, protects against NAFLD progression. However, the detailed mechanism and potential effects on the intestinal function still remain unclear.
   Methods & Results
   Two weeks after feeding mice a MCD+HF diet, the livers of human PRDX4 transgenic (Tg) mice exhibited significant suppression in the development of NAFLD compared with wildtype (WT) mice. The serum thiobarbituric acid reactive substances levels were significantly lower in Tg mice. In contrast, the Tg small intestine with PRDX4 overexpression showed more suppressed shortening of total length and villi height, and more accumulation of lipid in the jejunum, along with lower levels of dihydroethidium binding. The enterocytes exhibited fewer apoptotic but more proliferating cells, and inflammation was reduced in the mucosa. Furthermore, the small intestine of Tg mice had significantly higher expression of cholesterol absorption-regulatory factors, including liver X receptor-alpha, but lower expression of microsomal triglyceride-transfer protein.
   Conclusion
   Our present data provide the first evidence of the beneficial effects of PRDX4 on intestinal function in the reduction of the severity of NAFLD, by ameliorating oxidative stress-induced local and systemic injury. We can suggest that both liver and intestine are spared, to some degree, by the antioxidant properties of PRDX4.
C1 [Nawata, Aya; Noguchi, Hirotsugu; Wang, Ke-Yong; Guo, Xin; Sasaguri, Yasuyuki; Nakayama, Toshiyuki; Yamada, Sohsuke] Univ Occupat & Environm Hlth, Sch Med, Dept Pathol & Cell Biol, Kitakyushu, Fukuoka 8078555, Japan.
   [Nawata, Aya; Tanaka, Yoshiya] Univ Occupat & Environm Hlth, Sch Med, Dept Internal Med 1, Kitakyushu, Fukuoka 8078555, Japan.
   [Mazaki, Yuichi] Hokkaido Univ, Grad Sch Med, Dept Cellular Pharmacol, Sapporo, Hokkaido 0608638, Japan.
   [Kurahashi, Toshihiro; Fujii, Junichi] Yamagata Univ, Grad Sch Med Sci, Dept Biomol Funct, Yamagata 9909585, Japan.
   [Izumi, Hiroto] Univ Occupat & Environm Hlth, Sch Med, Dept Occupat Pneumol, Kitakyushu, Fukuoka 8078555, Japan.
   [Wang, Ke-Yong] Univ Occupat & Environm Hlth, Sch Med, Shared Use Res Ctr, Kitakyushu, Fukuoka 8078555, Japan.
   [Guo, Xin] Univ Occupat & Environm Hlth, Sch Med, Dept Surg 2, Kitakyushu, Fukuoka 8078555, Japan.
   [Uramoto, Hidetaka] Med Univ, Hebei Canc Inst, Hosp Hebei 4, Pathol Lab, Jiankang Rd 12, Shijiazhuang 050011, Hebei, Peoples R China.
   [Uramoto, Hidetaka] Saitama Canc Ctr, Dept Thorac Surg, 818 Komuro, Ina, Saitama 3620806, Japan.
   [Kohno, Kimitoshi] Univ Occupat & Environm Hlth, Sch Med, President Lab, Kitakyushu, Fukuoka 8078555, Japan.
   [Kohno, Kimitoshi] Asahi Matsumoto Hosp, Kitakyushu, Fukuoka 8000242, Japan.
   [Taniguchi, Hatsumi] Univ Occupat & Environm Hlth, Dept Microbiol, Kitakyushu, Fukuoka 8078555, Japan.
   [Sasaguri, Yasuyuki] Fukuoka Wajiro Hosp, Pathol Lab, Fukuoka 8110213, Japan.
   [Tanimoto, Akihide; Yamada, Sohsuke] Kagoshima Univ, Dept Pathol, Field Oncol, Grad Sch Med & Dent Sci, Kagoshima 8908544, Japan.
   [Yamada, Sohsuke] Med Univ Graz, Inst Pathol, A-8010 Graz, Austria.
   [Yamada, Sohsuke] Graz Univ, Inst Mol Biosci, A-8010 Graz, Austria.
C3 University of Occupational & Environmental Health - Japan; University of
   Occupational & Environmental Health - Japan; Hokkaido University;
   Yamagata University; University of Occupational & Environmental Health -
   Japan; University of Occupational & Environmental Health - Japan;
   University of Occupational & Environmental Health - Japan; University of
   Occupational & Environmental Health - Japan; University of Occupational
   & Environmental Health - Japan; Kagoshima University; Medical University
   of Graz; University of Graz
RP Yamada, S (corresponding author), Univ Occupat & Environm Hlth, Sch Med, Dept Pathol & Cell Biol, Kitakyushu, Fukuoka 8078555, Japan.; Yamada, S (corresponding author), Kagoshima Univ, Dept Pathol, Field Oncol, Grad Sch Med & Dent Sci, Kagoshima 8908544, Japan.; Yamada, S (corresponding author), Med Univ Graz, Inst Pathol, A-8010 Graz, Austria.; Yamada, S (corresponding author), Graz Univ, Inst Mol Biosci, A-8010 Graz, Austria.
EM sohsuke@m.kufm.kagoshima-u.ac.jp
RI Nawata, Aya/AHA-1272-2022
OI Mazaki, Yuichi/0000-0003-4192-0834; wang, ke-yong/0000-0001-8295-1229
FU Ministry of Education, Culture, Sports, Science and Technology, Tokyo,
   Japan [24790394]; Fukuoka Foundation for Sound Health Cancer Research
   Fund, Fukuoka, Japan; Grants-in-Aid for Scientific Research [15K08294,
   16K08750, 24790394] Funding Source: KAKEN
FX This work was supported in part by Grants-in-Aid for Scientific Research
   (24790394) from the Ministry of Education, Culture, Sports, Science and
   Technology, Tokyo, Japan (to S.Y.) and by the Fukuoka Foundation for
   Sound Health Cancer Research Fund, Fukuoka, Japan (to S.Y.). The funders
   had no role in study design, data collection and analysis, decision to
   publish, or preparation of the manuscript.
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NR 44
TC 27
Z9 27
U1 0
U2 11
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD APR 1
PY 2016
VL 11
IS 4
AR e0152549
DI 10.1371/journal.pone.0152549
PG 25
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA DI0QF
UT WOS:000373201200021
PM 27035833
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Edirisinghe, I
   Burton-Freeman, B
AF Edirisinghe, Indika
   Burton-Freeman, Britt
TI Anti-diabetic actions of Berry polyphenols - Review on proposed
   mechanisms of action
SO JOURNAL OF BERRY RESEARCH
LA English
DT Review
DE Anthocyanins; insulin; glucose; berry fruits; glycemic control
ID ACTIVATED PROTEIN-KINASE; PANCREATIC BETA-CELLS; INSULIN-RESISTANCE;
   HUMAN HEALTH; AMELIORATES HYPERGLYCEMIA; ANTIOXIDANT CAPACITY; METABOLIC
   SYNDROME; GLUCOSE-UPTAKE; HEART-DISEASE; DIABETIC MICE
AB The incidence of type 2 diabetes mellitus (T2DM) has reached near-epidemic proportions in the Western world with other parts of the world following close behind. Glycemic control is paramount in type 1 diabetes mellitus (T1DM) and T2DM. Berries may beneficially influence glycemic control through the action of their polyphenolic components. While clinical studies on the anti-diabetic effects of berry polyphenols are limited, epidemiological data have indicated favorable effects of berry/anthocyanins intake on development and/or management of T2DM. Furthermore, data derived from in vivo animal studies and in vitro cell culture models are promising. Various molecular targets and modulation of cell signaling pathways in pancreatic beta-cells, hepatocytes, adipocytes, and skeletal muscle cells are among the proposed mechanisms for berry polyphenols and their metabolites' action. Berry polyphenols may exert anti-diabetic effects by (i) enhancing insulin production and reducing apoptosis and promoting proliferation of pancreatic beta-cells, (ii) regulating glucose metabolism by interfering with absorption or by increasing peripheral tissue glucose uptake through insulin receptor-dependent or independent mechanisms via modification of oxidative stress, inflammation or perceived energy status of cell. This mini review discusses recent findings from our laboratory and other studies on the anti-diabetic effects of berry polyphenolic compounds with special emphasis on the cellular and molecular mechanisms involved in the beneficial effects of berry polyphenol compounds.
C1 [Edirisinghe, Indika; Burton-Freeman, Britt] IIT, Inst Food Safety & Hlth, Ctr Nutr Res, Bedford Pk, IL USA.
C3 Illinois Institute of Technology
RP Edirisinghe, I (corresponding author), IIT, Inst Food Safety & Hlth, 6502 South Archer Rd, Bedford Pk, IL 60501 USA.
EM iedirisi@iit.edu
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NR 56
TC 69
Z9 77
U1 3
U2 30
PU IOS PRESS
PI AMSTERDAM
PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS
SN 1878-5093
EI 1878-5123
J9 J BERRY RES
JI J. Berry Res.
PY 2016
VL 6
IS 2
BP 237
EP 250
DI 10.3233/JBR-160137
PG 14
WC Plant Sciences; Food Science & Technology; Horticulture; Nutrition &
   Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Food Science & Technology; Agriculture; Nutrition &
   Dietetics
GA EH0FJ
UT WOS:000391438300014
OA Bronze
DA 2025-06-11
ER

PT J
AU Egan, BM
   Laken, MA
AF Egan, Brent M.
   Laken, Marilyn A.
TI Pre-Hypertension: Rationale for Pharmacotherapy
SO CURRENT HYPERTENSION REPORTS
LA English
DT Article
DE Pre-hypertension; Incident hypertension; Racial differences; Metabolic
   syndrome; Cardiovascular risk; Pharmacotherapy
ID CARDIOVASCULAR-DISEASE RISK; NORMAL BLOOD-PRESSURE; OXIDATIVE STRESS;
   HYPERTENSION; PREVENTION; STROKE; ADULTS; IMPACT; TRIAL
AB Pre-hypertension, defined as blood pressure 120-139/80-89 mmHg, affects 70 million people in the US. Blood pressures in the upper half of the pre-hypertensive range are linked with roughly threefold greater risk of incident hypertension than normal blood pressure < 120/< 80 mmHg, with an incidence rate of 8-20 % annually. Blood pressures in the upper half of the pre-hypertensive range also roughly double risk for cardiovascular events, even in the absence of progression to hypertension. Despite excess risk, guidelines recommend lifestyle interventions only for people with pre-hypertension in the absence of diabetes mellitus or clinical cardiovascular or chronic kidney disease. While efficacious, lifestyle changes have limited population effectiveness as Americans are heavier and their nutritional patterns less DASH-like than before DASH was published. Prevalent hypertension is higher in African Americans than Caucasians, but prevalent pre-hypertension is similar. African Americans experience a more rapid transition from pre-hypertension to hypertension than Caucasians with pre-hypertension. Interventions that normalize racial differences in incident hypertension could, over time, improve racial equity in prevalent hypertension and related clinical complications. Individuals with pre-hypertension can be safely treated with antihypertensive medications to significantly reduce incident hypertension. Given the evidence, practical clinical trials in African Americans with pre-hypertension to reduce and eliminate racial disparities in incident hypertension have merit. The results of these trials could provide the foundation for clinical guidelines to reduce racial disparities in prevalent hypertension and associated clinical cardiovascular and renal diseases.
C1 [Egan, Brent M.] Univ S Carolina, Sch Med Greenville, Care Coordinat Inst, Greenville Hlth Syst, Greenville, SC 29602 USA.
   [Laken, Marilyn A.] Med Univ S Carolina, Charleston, SC 29425 USA.
   [Egan, Brent M.] Univ S Carolina, Sch Med Greenville, Care Coordinat Inst, Greenville, SC 29602 USA.
C3 University of South Carolina System; University of South Carolina
   Columbia; Greenville Health System; Medical University of South
   Carolina; University of South Carolina System; University of South
   Carolina Columbia
RP Egan, BM (corresponding author), Univ S Carolina, Sch Med Greenville, Care Coordinat Inst, POB 367, Greenville, SC 29602 USA.
EM began@carecoordinationinstitute.org
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NR 37
TC 4
Z9 5
U1 0
U2 11
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1522-6417
EI 1534-3111
J9 CURR HYPERTENS REP
JI Curr. Hypertens. Rep.
PD DEC
PY 2013
VL 15
IS 6
BP 669
EP 675
DI 10.1007/s11906-013-0387-7
PG 7
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 258TZ
UT WOS:000327482900016
PM 24142744
DA 2025-06-11
ER

PT J
AU Shi, SY
   Martin, RG
   Duncan, RE
   Choi, D
   Lu, SY
   Schroer, SA
   Cai, EP
   Luk, CT
   Hopperton, KE
   Domenichiello, AF
   Tang, C
   Naples, M
   Dekker, MJ
   Giacca, A
   Adeli, K
   Wagner, KU
   Bazinet, RP
   Woo, M
AF Shi, Sally Yu
   Martin, Ruben Garcia
   Duncan, Robin E.
   Choi, Diana
   Lu, Shun-Yan
   Schroer, Stephanie A.
   Cai, Erica P.
   Luk, Cynthia T.
   Hopperton, Kathryn E.
   Domenichiello, Anthony F.
   Tang, Christine
   Naples, Mark
   Dekker, Mark J.
   Giacca, Adria
   Adeli, Khosrow
   Wagner, Kay-Uwe
   Bazinet, Richard P.
   Woo, Minna
TI Hepatocyte-specific Deletion of Janus Kinase 2 (JAK2) Protects against
   Diet-induced Steatohepatitis and Glucose Intolerance
SO JOURNAL OF BIOLOGICAL CHEMISTRY
LA English
DT Article
ID FATTY LIVER-DISEASE; BETA-CELL HYPERPLASIA; GROWTH-HORMONE;
   INSULIN-RESISTANCE; HEPATIC STEATOSIS; RECEPTOR; MICE; INHIBITION;
   EXPRESSION; INFLAMMATION
AB Non-alcoholic fatty liver disease (NAFLD) is becoming the leading cause of chronic liver disease and is now considered to be the hepatic manifestation of the metabolic syndrome. However, the role of steatosis per se and the precise factors required in the progression to steatohepatitis or insulin resistance remain elusive. The JAK-STAT pathway is critical in mediating signaling of a wide variety of cytokines and growth factors. Mice with hepatocyte-specific deletion of Janus kinase 2 (L-JAK2 KO mice) develop spontaneous steatosis as early as 2 weeks of age. In this study, we investigated the metabolic consequences of jak2 deletion in response to diet-induced metabolic stress. To our surprise, despite the profound hepatosteatosis, deletion of hepatic jak2 did not sensitize the liver to accelerated inflammatory injury on a prolonged high fat diet (HFD). This was accompanied by complete protection against HFD-induced whole-body insulin resistance and glucose intolerance. Improved glucose-stimulated insulin secretion and an increase in beta-cell mass were also present in these mice. Moreover, L-JAK2 KO mice had progressively reduced adiposity in association with blunted hepatic growth hormone signaling. These mice also exhibited increased resting energy expenditure on both chow and high fat diet. In conclusion, our findings indicate a key role of hepatic JAK2 in metabolism such that its absence completely arrests steatohepatitis development and confers protection against diet-induced systemic insulin resistance and glucose intolerance.
C1 [Shi, Sally Yu; Martin, Ruben Garcia; Choi, Diana; Lu, Shun-Yan; Schroer, Stephanie A.; Cai, Erica P.; Luk, Cynthia T.; Woo, Minna] Toronto Gen Res Inst, Toronto, ON M5G 2C4, Canada.
   [Shi, Sally Yu; Choi, Diana; Cai, Erica P.; Luk, Cynthia T.; Woo, Minna] Univ Toronto, Inst Med Sci, Toronto, ON M5G 2M9, Canada.
   [Duncan, Robin E.; Hopperton, Kathryn E.; Domenichiello, Anthony F.; Bazinet, Richard P.] Univ Toronto, Dept Nutr Sci, Toronto, ON M5S 3E2, Canada.
   [Tang, Christine; Giacca, Adria] Univ Toronto, Dept Physiol, Fac Med, Toronto, ON M5S 1A8, Canada.
   [Naples, Mark; Dekker, Mark J.; Adeli, Khosrow] Univ Toronto, Hosp Sick Children, Res Inst, Toronto, ON M5G 1X8, Canada.
   [Wagner, Kay-Uwe] Univ Nebraska Med Ctr, Eppley Inst Res Canc & Allied Dis, Omaha, NE 68198 USA.
   [Wagner, Kay-Uwe] Univ Nebraska Med Ctr, Dept Pathol & Microbiol, Omaha, NE 68198 USA.
   [Woo, Minna] St Michaels Hosp, Dept Med, Toronto, ON M3B 1W5, Canada.
   [Woo, Minna] St Michaels Hosp, Keenan Res Ctr, Li Ka Shing Knowledge Inst, Toronto, ON M3B 1W5, Canada.
C3 University of Toronto; University Health Network Toronto; Toronto
   General Hospital; University of Toronto; University of Toronto;
   University of Toronto; University of Toronto; Hospital for Sick Children
   (SickKids); University of Nebraska System; University of Nebraska
   Medical Center; University of Nebraska System; University of Nebraska
   Medical Center; University of Toronto; Saint Michaels Hospital Toronto;
   University of Toronto; Saint Michaels Hospital Toronto; Li Ka Shing
   Knowledge Institute
RP Woo, M (corresponding author), MaRS Ctr, Toronto Med Discovery Tower,101 Coll St,10th Floo, Toronto, ON M5G 1L7, Canada.
EM mwoo@uhnres.utoronto.ca
RI Wagner, Kay-Uwe/B-6044-2009; Rao, Jagadeesh/GRN-8594-2022; Cai,
   Erica/ABE-4408-2020; Duncan, Robin/AAH-7465-2021; Woo,
   Minna/KOC-0684-2024; Martin, Ruben/AAA-8538-2021
OI Garcia Martin, Ruben/0000-0003-2049-4960; Hopperton,
   Kathryn/0000-0003-0146-2744; Cai, Erica/0000-0003-2386-5747; Shi, Sally
   Yu/0000-0002-5528-3824; Wagner, Kay-Uwe/0000-0002-5081-0226; Adeli,
   Khosrow/0000-0002-5839-5709
FU Canadian Institute of Health Research [MOP-191501]; Canadian Diabetes
   Association; Banting and Best Diabetes Centre (BBDC)-Novo Nordisk;
   NSERC; Spanish National Research Fellowship from Ibercaja Foundation
   (Spain); CIHR Federick Banting; Charles Best Canada Graduate Scholarship
   - Doctoral; Eliot Phillipson Clinician Scientist Training Program; BBDC
FX This work was supported by operating grants from Canadian Institute of
   Health Research MOP-191501 and Canadian Diabetes Association (to M.
   W.).Supported by the Banting and Best Diabetes Centre (BBDC)-Novo
   Nordisk Studentship and the NSERC Alexander Graham Bell Canada Graduate
   Scholarship.Supported by the Spanish National Research Fellowship from
   Ibercaja Foundation (Spain).Supported by the CIHR Federick Banting and
   Charles Best Canada Graduate Scholarship - Doctoral.Supported by the
   Canadian Diabetes Association Doctoral Student Research Award.Supported
   by the Eliot Phillipson Clinician Scientist Training Program and the
   BBDC post-doctoral fellowship.
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NR 44
TC 60
Z9 67
U1 0
U2 7
PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3996 USA
SN 0021-9258
EI 1083-351X
J9 J BIOL CHEM
JI J. Biol. Chem.
PD MAR 23
PY 2012
VL 287
IS 13
BP 10277
EP 10288
DI 10.1074/jbc.M111.317453
PG 12
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 917IN
UT WOS:000302167200057
PM 22275361
OA Green Published
DA 2025-06-11
ER

PT J
AU Ginter, E
   Simko, V
   Dolinska, S
AF Ginter, E.
   Simko, V
   Dolinska, S.
TI Paradoxes in medicine: an access to new knowledge?
SO BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY
LA English
DT Article
DE paradoxes; life expectancy; nutrition; obesity; cardiovascular diseases
ID METABOLIC SYNDROME; RISK; PATHOPHYSIOLOGY; CONSUMPTION
AB The analysis of health and nutrition data from various countries shows many surprising and seemingly incomprehensible facts and paradoxical relationships. Health status of a country is the result of long-term factors and therefore it cannot be changed from day to day. For example in Central European countries there was a sudden increase in life expectancy after the fall of Soviet hegemony. French paradox is the oldest example of apparent contrast between "unhealthy" nutrition and low cardiovascular mortality. Although, the consumption of animal fat and milk and milk products in Switzerland is very high, but premature cardiovascular mortality of Swiss men and women is the lowest in Europe. In USA there is concominant increase of obesity and decrease in cardiovascular mortality. In Cuba, in spite of great economic problems its relatively high male and female life expectancy is very similar to the rich USA. The life expectancy in Albania is significantly higher than in many countries in Central Europe and in the Balkan region, in spite of the fact that Albania remains the poorest European country. Analysis of these unexpected and paradoxical relations indicate the importance of the quality of medical care, control of cardiovascular risk factors (USA) and the influence of modest but biologically balanced diet on low prevalence of cardiovascular disease in Cuba and Albania. The experience from former communist Central European countries suggests important influence of chronic stress and psychosocial factors on heart diseases and life expectancy. These paradoxes open the door to new information (Fig. 5, Ref. 11). Full Text (Free, PDF) www.bmj.sk.
C1 [Ginter, E.] Inst Prevent & Clin Med, Bratislava, Slovakia.
   [Simko, V] SUNY Hlth Sci Ctr, Brooklyn, NY 11203 USA.
   [Dolinska, S.] Safarik Univ, Inst Biol & Ecol, Fac Sci, Kosice, Slovakia.
C3 State University of New York (SUNY) System; SUNY Downstate Health
   Sciences University; University of Pavol Jozef Safarik Kosice
RP Ginter, E (corresponding author), Racianska 17, SK-83102 Bratislava, Slovakia.
EM ginter.emil@mail.t-com.s
OI Drutovic, Saskia/0000-0002-5103-5073
CR [Anonymous], 2007, EUR MORT DAT
   [Anonymous], 2007, EUR HLTH ALL DAT
   Elwood PC, 2007, J EPIDEMIOL COMMUN H, V61, P695, DOI 10.1136/jech.2006.053157
   Ginter E, 2008, BRATISL MED J, V109, P224
   Ginter E, 2007, BRATISL MED J, V108, P417
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   Pariza MW, 2004, AM J CLIN NUTR, V79, p1132S
   Reaven G, 2002, CIRCULATION, V106, P286, DOI 10.1161/01.CIR.0000019884.36724.D9
   2003, J AM MED ASS, V290, P932
NR 11
TC 3
Z9 3
U1 0
U2 1
PU COMENIUS UNIV
PI BRATISLAVA I
PA SCH MEDICINE, SPITALSKA 24, BRATISLAVA I, SK-813 72, SLOVAKIA
SN 0006-9248
EI 1336-0345
J9 BRATISL MED J
JI Bratisl. Med. J.
PY 2009
VL 110
IS 2
BP 112
EP 115
PG 4
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 418PB
UT WOS:000264159400010
PM 19408844
DA 2025-06-11
ER

PT J
AU Arendt, BM
   Aghdassi, E
   Mohammed, SS
   Fung, LY
   Jalali, P
   Salit, IE
   Allard, JP
AF Arendt, Bianca Maria
   Aghdassi, Elaheh
   Mohammed, Saira Saddia
   Fung, Lillia Yan
   Jalali, Pegah
   Salit, Irving Elliot
   Allard, Johane Pierette
TI Dietary intake and physical activity in a Canadian population sample of
   male patients with HIV infection and metabolic abnormalities
SO CURRENT HIV RESEARCH
LA English
DT Article
DE HIV; diet; nutrition; micronutrients; physical activity; metabolic
   abnormalities
ID IMMUNODEFICIENCY-VIRUS INFECTION; DISEASE RISK-FACTORS; OXIDATIVE
   STRESS; INSULIN-RESISTANCE; ANTIRETROVIRAL THERAPY; ENERGY-EXPENDITURE;
   DIABETES-MELLITUS; NATIONAL-HEALTH; NUTRIENT INTAKE; LIVER-DISEASE
AB Objective was to assess dietary intake and physical activity in a Canadian population sample of male patients with HIV and metabolic abnormalities and to compare the data to Canadian recommendations. Sixty-five HIV-infected men with at least one feature associated with the metabolic syndrome (insulin resistance, dyslipidemia, central obesity, or lipodystrophy) were enrolled. Results from 7-day food records and activity logs were compared to the Dietary Reference Intakes and recommendations of Canada's Physical Activity Guide, respectively. Anthropometric data were also measured. Fifty-two percent of the subjects were overweight, another 15% were obese. However, energy intake (mean +/- SEM) (2153 +/- 99 kcal/d) was lower than the estimated requirement (2854 +/- 62 kcal/d; p < 0.0001), and 84.5% of the patients reached the recommended minimum of 60 min of mild or 30 min of moderate daily exercise. Intake was adequate for protein, but high for fat and cholesterol in 40% of patients. No patient reached the recommendation for fiber. Intake from diet alone was suboptimal for most micronutrients. Prevalence was highest for low vitamin E (91% of patients) and magnesium (68%) intake, and high sodium intake (72%). In summary, a large proportion of HIV patients with metabolic abnormalities were overweight or obese. However, this was not associated with high energy intake, or reduced physical activity. High fat, low fiber and inadequate micronutrient intakes were prevalent.
C1 [Arendt, Bianca Maria; Aghdassi, Elaheh; Mohammed, Saira Saddia; Fung, Lillia Yan; Jalali, Pegah; Salit, Irving Elliot; Allard, Johane Pierette] Univ Toronto, Univ Hlth Network, Dept Med, Toronto, ON, Canada.
C3 University of Toronto; University Health Network Toronto
RP Allard, JP (corresponding author), Toronto Gen Hosp, 200 Elizabeth St,Suite 9NU-973, Toronto, ON M5G 2C4, Canada.
EM johane.allard@uhn.on.ca
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NR 80
TC 17
Z9 18
U1 0
U2 2
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1570-162X
EI 1873-4251
J9 CURR HIV RES
JI Curr. HIV Res.
PD JAN
PY 2008
VL 6
IS 1
BP 82
EP 90
PG 9
WC Immunology; Infectious Diseases; Virology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Infectious Diseases; Virology
GA 273UY
UT WOS:000253958500012
PM 18288980
DA 2025-06-11
ER

PT J
AU Zafiropoulos, A
   Linardakis, M
   Jansen, EHJM
   Tsatsakis, AM
   Kafatos, A
   Tzanakakis, GN
AF Zafiropoulos, Alexandros
   Linardakis, Manolis
   Jansen, Eugene H. J. M.
   Tsatsakis, Aristidis M.
   Kafatos, Antonis
   Tzanakakis, George N.
TI Paraoxonase 1 R/Q alleles are associated with differential accumulation
   of saturated versus 20:5n3 fatty acid in human adipose tissue
SO JOURNAL OF LIPID RESEARCH
LA English
DT Article
DE lipidomics; dyslipidemia; lipid homeostasis
ID HUMAN SERUM PARAOXONASE; DENSITY-LIPOPROTEIN OXIDATION; CORONARY
   HEART-DISEASE; SELECTIVE MOBILIZATION; CARDIOVASCULAR-DISEASE; GENE
   POLYMORPHISMS; MOLECULAR-BASIS; RISK; PREVENTION; DEPRESSION
AB Serum paraoxonase 1 (PON1) function has been associated with human cardiovascular disease. The projected mechanism postulates interaction of PON1 with lipo-proteins and insulin signaling resulting in alterations in lipid homeostasis. Recently, PON2 was shown to directly regulate triglyceride accumulation in macrophages and PON1 was detected in the interstitial space of adipocytes. The aims of the present study were a) to examine the relationship of the PON1 function with serum parameters related to lipid homeostasis, and b) to examine a possible role of PON1 in the regulation of lipid composition in the human adipose tissue. Two important genetic variations with functional impact on PON1 activity in humans are the Q192R and the L55M. The present study evaluated the impact of the Q192R and the L55M polymorphisms in a cross-section of the population on the island of Crete, as regards to PON1 activity, plasma lipids/lipoproteins, parameters of the metabolic syndrome, and the fatty acid composition of the adipose tissue.jlr We detected a significant association of the polymorphisms with blood pressure, fasting blood glucose, triglycerides, apolipoprotein B, serum iron, and homocysteine. Furthermore, a novel function is suggested for PON1 on the fatty acid composition in the adipose tissue through the positive association of the R allele with saturated fatty acid and of the Q allele with 20:5n3 fatty acid deposition.-Zafiropoulos, A., M. Linardakis, E. H. J. M. Jansen, A. M. Tsatsakis, A. Kafatos, and G. N. Tzanakakis. Paraoxonase 1 R/Q alleles are associated with differential accumulation of saturated versus 20:5n3 fatty acid in human adipose tissue. J. Lipid Res. 2010. 51: 1991-2000.
C1 [Zafiropoulos, Alexandros; Tzanakakis, George N.] Univ Crete, Sch Med, Dept Histol, Iraklion 71409, Crete, Greece.
   [Linardakis, Manolis; Kafatos, Antonis] Univ Crete, Sch Med, Dept Social Med, Iraklion 71409, Crete, Greece.
   [Tsatsakis, Aristidis M.] Univ Crete, Sch Med, Prevent Med & Nutr Clin, Iraklion 71409, Crete, Greece.
   [Tsatsakis, Aristidis M.] Univ Crete, Sch Med, Ctr Toxicol Sci & Res, Iraklion 71409, Crete, Greece.
   [Jansen, Eugene H. J. M.] Natl Inst Publ Hlth & Environm, Lab Hlth Protect Res, NL-3720 BA Bilthoven, Netherlands.
C3 University of Crete; University of Crete; University of Crete;
   University of Crete; Netherlands National Institute for Public Health &
   the Environment
RP Zafiropoulos, A (corresponding author), Univ Crete, Sch Med, Dept Histol, Iraklion 71409, Crete, Greece.
EM zafeiros@med.uoc.gr
RI Linardakis, Manolis/T-8147-2019; Tzanakakis, George/ABH-7725-2020;
   TSATSAKIS, ARISTIDIS/H-2890-2013
OI Zafiropoulos, Alexandros/0000-0002-8042-9899; TSATSAKIS,
   ARISTIDIS/0000-0003-3824-2462; Linardakis, Manolis/0000-0003-3849-3907;
   Tzanakakis, George/0000-0001-5276-4764
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NR 47
TC 14
Z9 14
U1 0
U2 2
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0022-2275
EI 1539-7262
J9 J LIPID RES
JI J. Lipid Res.
PD JUL
PY 2010
VL 51
IS 7
BP 1991
EP 2000
DI 10.1194/jlr.P004960
PG 10
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 609BB
UT WOS:000278628700035
PM 20133274
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Champagne, KA
   Kimoff, RJ
   Barriga, PC
   Schwartzman, K
AF Champagne, Kateri Agnes
   Kimoff, R. John
   Barriga, Peter Charles
   Schwartzman, Kevin
TI Sleep disordered breathing in women of childbearing age & during
   pregnancy
SO INDIAN JOURNAL OF MEDICAL RESEARCH
LA English
DT Review
DE Gender; gestational hypertension; obesity; preeclampsia; pregnancy;
   sleep apnoea
ID POSITIVE AIRWAY PRESSURE; POLYCYSTIC-OVARY-SYNDROME; FETAL-GROWTH
   RESTRICTION; RISK-FACTORS; DAYTIME SLEEPINESS; APNEA SYNDROME;
   INDUCED-HYPERTENSION; BERLIN QUESTIONNAIRE; BLOOD-PRESSURE;
   INSULIN-RESISTANCE
AB Obstructive sleep apnoea (OSA) affects 11 per cent of pre-menopausal women though it often remains undetected. Women may present differently than men, and the classic findings of snoring, witnessed apnoeas and sleepiness may not be observed. Factors which predispose to OSA include polycystic ovarian syndrome, obesity, retromicrognathia, and hypothyroidism. OSA may contribute to neurocognitive dysfunction, depression, hypertension and metabolic syndrome. Emerging evidence indicates that snoring and OSA increase during pregnancy. For normal women with normotensive, low-risk pregnancies the prevalence of OSA is very low. Among normotensive pregnant women with high risk pregnancies, the prevalence of OSA is high and is even higher among those with gestational hypertension/preeclampsia during pregnancy. Incident snoring, which is a marker for OSA, is associated with an increased risk of developing gestational hypertension. Recent studies indicate that OSA per se is an independent risk factor for gestational hypertension/pre-eclampsia and may contribute to other poor obstetrical outcomes. The diagnostic test of choice for OSA is a polysomnography with electroencephalogram. Milder degree of disease than what is usually considered clinically significant among men or non-pregnant women appears to be relevant for foetomaternal outcomes. There seems to be benefit for blood pressure control to treating even milder degrees of OSA with CPAP, both acutely and over the 9 months of pregnancy. Chronic hypertensive women should be strongly considered for diagnosis and treatment of OSA prior to or beginning as early as possible in pregnancy to help maintain blood pressure control. Increasing awareness of OSA among maternal health care providers is important given the potential benefits for pregnancy and other health-related outcomes associated with identification and treatment of OSA.
C1 [Champagne, Kateri Agnes; Kimoff, R. John; Schwartzman, Kevin] McGill Univ, Ctr Hlth, Dept Med, Resp Epidemiol & Clin Res Unit, Montreal, PQ, Canada.
   [Barriga, Peter Charles] Santa Cabrini Hosp, Dept Microbiol, Montreal, PQ, Canada.
C3 McGill University
RP Champagne, KA (corresponding author), Montreal Chest Inst K1 13, Resp Epidemiol & Clin Res Unit, 3650 St Urbain, Montreal, PQ H2X 2P4, Canada.
EM kateri.champagne@muhc.mcgill.ca
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NR 137
TC 27
Z9 33
U1 0
U2 15
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, 400059, INDIA
SN 0971-5916
J9 INDIAN J MED RES
JI Indian J. Med. Res.
PD FEB
PY 2010
VL 131
IS 2
SI SI
BP 285
EP 301
PG 17
WC Immunology; Medicine, General & Internal; Medicine, Research &
   Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; General & Internal Medicine; Research & Experimental
   Medicine
GA 569XD
UT WOS:000275635200020
PM 20308754
DA 2025-06-11
ER

PT J
AU Golden, SH
   Malhotra, S
   Wand, GS
   Brancati, FL
   Ford, D
   Horton, K
AF Golden, Sherita Hill
   Malhotra, Saurabh
   Wand, Gary S.
   Brancati, Frederick L.
   Ford, Daniel
   Horton, Karen
TI Adrenal gland volume and dexamethasone-suppressed cortisol correlate
   with total daily salivary cortisol in African-American women
SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Article
ID CORONARY-HEART-DISEASE; SUBCLINICAL CUSHINGS-SYNDROME; TYPE-2
   DIABETES-MELLITUS; BODY-FAT DISTRIBUTION; DEPRESSIVE SYMPTOMS; ABDOMINAL
   OBESITY; ATHEROSCLEROSIS RISK; METABOLIC SYNDROME; MAJOR DEPRESSION;
   AXIS FUNCTION
AB Context: Population-based studies of associations between subclinical hypercortisolism and risk for disease states, such as type 2 diabetes mellitus, have been difficult to assess because of imprecise measures of glucocorticoid exposure. Alternative measures (salivary cortisol and adrenal gland volume) have not been systematically compared with 24-h urine free cortisol (UFC) in a healthy population.
   Objective: Our objectives were: 1) to determine whether 24-h UFC and total daily salivary cortisol correlated with each other, adrenal gland volume, and salivary cortisol after dexamethasone suppression and 2) to evaluate the association of adrenal gland volume with salivary cortisol after dexamethasone suppression.
   Design, Setting, and Participants: This was a cross-sectional study of 20 healthy, premenopausal African-American women aged 18-45 yr.
   Main Outcome Measures: Salivary cortisol was assessed at six time points throughout the day simultaneous with 24-h UFC collection. Adrenal gland volume was measured by computed tomography scan. Dexamethasone-suppressed salivary cortisol was measured at 0800 h after administration of 0.5 mg dexamethasone at 2300 h the prior evening.
   Results: Dexamethasone-suppressed salivary cortisol levels correlated strongly with individual, timed salivary cortisol measurements, total daily salivary cortisol (r(s) = 0.75; P = 0.0001; n = 20), and adrenal gland volume (r(s) = 0.66; P = 0.004; n = 17). Total daily salivary cortisol and adrenal gland volume also correlated (r(s) = 0.46; P = 0.04; n = 19). In contrast, 24-h UFC levels did not correlate with any of the other hypothalamic-pituitary-adrenal axis measures.
   Conclusion: A dexamethasone suppression test or adrenal gland volume may be alternative measures for characterizing subtle subclinical hypercortisolism in healthy adults.
C1 Johns Hopkins Univ, Sch Med, Div Endocrinol & Metab, Dept Med, Baltimore, MD 21205 USA.
   Johns Hopkins Univ, Sch Med, Dept Psychiat, Baltimore, MD 21205 USA.
   Johns Hopkins Univ, Sch Med, Dept Radiol, Baltimore, MD 21205 USA.
   Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD 21205 USA.
   Univ Pittsburgh, Med Ctr, Dept Med, Pittsburgh, PA 15213 USA.
C3 Johns Hopkins University; Johns Hopkins University; Johns Hopkins
   University; Johns Hopkins University; Johns Hopkins Bloomberg School of
   Public Health; Pennsylvania Commonwealth System of Higher Education
   (PCSHE); University of Pittsburgh
RP Golden, SH (corresponding author), Johns Hopkins Univ, Sch Med, Div Endocrinol & Metab, Dept Med, 2024 E Monument St,Suite 2-616, Baltimore, MD 21205 USA.
EM sahill@jhmi.edu
FU NCRR NIH HHS [M01-RR00052] Funding Source: Medline; NIDDK NIH HHS [5 K23
   DK071565] Funding Source: Medline
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NR 51
TC 20
Z9 21
U1 0
U2 3
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0021-972X
EI 1945-7197
J9 J CLIN ENDOCR METAB
JI J. Clin. Endocrinol. Metab.
PD APR
PY 2007
VL 92
IS 4
BP 1358
EP 1363
DI 10.1210/jc.2006-2674
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 153WH
UT WOS:000245466600029
PM 17284636
OA Bronze
DA 2025-06-11
ER

PT J
AU Zhang, F
   Sun, Y
   Bai, Y
   Wu, R
   Yang, H
AF Zhang, Fan
   Sun, Yan
   Bai, Yan
   Wu, Rong
   Yang, Hua
TI Association of triglyceride-glucose index and diabesity: evidence from a
   national longitudinal study
SO LIPIDS IN HEALTH AND DISEASE
LA English
DT Article
DE Triglyceride-glucose index; Diabesity; Obesity; Diabetes
ID METABOLIC SYNDROME; FASTING GLUCOSE; EPIDEMIOLOGY; ADULTS; RISK;
   METAANALYSIS; DEPRESSION; SURROGATE; PRODUCT; OBESITY
AB Background Diabesity, a co-occurrence of diabetes and obesity, is a growing public health concern globally. The triglyceride-glucose (TyG) index, a surrogate marker of insulin resistance, has been associated with various metabolic disorders. This study aimed to investigate the association between TyG index and new-onset diabesity in a national longitudinal study. Methods We utilized data from the China Health and Retirement Longitudinal Study (CHARLS). Baseline data from the first wave (2011) and follow-up data from the third wave (2015) were analyzed. A Competing risks model based on Fine and Gray's subdistribution hazard approach was employed to examine the association between the TyG index and developing of three mutually exclusive outcomes: remaining free of diabetes and obesity, diabetes alone, and new-onset diabesity (co-occurrence of diabetes and obesity). Results A total of 6,976 participants were included in the analysis. During a mean follow-up period of 4.0 years, a total of 557 diabetes and 155 diabesity were recorded, respectively. After adjusting for socio-demographic information, lifestyle and comorbidities, compared with participants in the lowest quartile of TyG, the corresponding adjusted subdistribution hazard ratios (HRs) with 95% confidence intervals (95% CIs) for participants in the second, third, and fourth quartiles were 2.112 (95% CI: 1.047-4.259; P-value = 0.037), 2.911 (95% CI: 1.481-5.722, P-value = 0.002), and 4.305 (95% CI: 2.220-8.346, P-value < 0.001). The association between TyG and diabetes alone was equally significant when diabesity treated as the competing risk. Sensitivity analyses proved the robustness of results. Conclusion This national longitudinal study in China provides evidence that a higher TyG index is associated with an increased risk of developing diabesity.
C1 [Zhang, Fan; Bai, Yan; Wu, Rong; Yang, Hua] Shanghai Univ Tradit Chinese Med, Dept Nephrol A, Longhua Hosp, Shanghai, Peoples R China.
   [Sun, Yan] Shanghai Univ Tradit Chinese Med, Dept Cardiol, Longhua Hosp, Shanghai, Peoples R China.
   [Wu, Rong; Yang, Hua] Shanghai Univ Tradit Chinese Med, Dept Endocrine, Longhua Hosp, 725 Wanping South Rd, Shanghai, Peoples R China.
C3 Shanghai University of Traditional Chinese Medicine; Shanghai University
   of Traditional Chinese Medicine; Shanghai University of Traditional
   Chinese Medicine
RP Wu, R; Yang, H (corresponding author), Shanghai Univ Tradit Chinese Med, Dept Nephrol A, Longhua Hosp, Shanghai, Peoples R China.; Wu, R; Yang, H (corresponding author), Shanghai Univ Tradit Chinese Med, Dept Endocrine, Longhua Hosp, 725 Wanping South Rd, Shanghai, Peoples R China.
EM wurong3344@126.com; yanghua@longhua.net
RI Zhang, Fan/GWV-6552-2022
FU Shanghai Municipal Health Commission
FX We thank the China Center for Economic Research at Peking University for
   providing us with the data, and the CHARLS research and field team for
   collecting the data.
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NR 36
TC 2
Z9 2
U1 5
U2 5
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1476-511X
J9 LIPIDS HEALTH DIS
JI Lipids Health Dis.
PD DEC 20
PY 2024
VL 23
IS 1
AR 412
DI 10.1186/s12944-024-02403-7
PG 10
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA Q0G1Z
UT WOS:001381571500002
PM 39707324
OA gold
DA 2025-06-11
ER

PT J
AU Sánchez-Carro, Y
   Portella, MJ
   Leal-Leturia, I
   Salvat-Pujol, N
   Etxandi, M
   de Arriba-Arnau, A
   Urretavizcaya, M
   Pousa, E
   Toll, A
   Alvarez, P
   Soria, V
   López-García, P
AF Sanchez-Carro, Yolanda
   Portella, Maria J.
   Leal-Leturia, Itziar
   Salvat-Pujol, Neus
   Etxandi, Mikel
   de Arriba-Arnau, Aida
   Urretavizcaya, Mikel
   Pousa, Esther
   Toll, Alba
   Alvarez, Pilar
   Soria, Virginia
   Lopez-Garcia, Pilar
TI Age at illness onset and physical activity are associated with cognitive
   impairment in patients with current diagnosis of major depressive
   disorder
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Major depressive disorder; Cognitive impairment; Years of schooling;
   Health-related variables; Physical activity; Age of onset
ID LATE-LIFE DEPRESSION; METABOLIC SYNDROME; NEUROPSYCHOLOGICAL FUNCTION;
   CORTICAL PLASTICITY; EXECUTIVE FUNCTION; MENTAL-ILLNESS; OLDER-ADULTS;
   EXERCISE; SMOKING; METAANALYSIS
AB Background. Cognitive impairment has been reported in patients with Major Depressive Disorder (MDD). This study aims to explore the association between lifestyle habits and health-related factors and the presence of cognitive symptoms in MDD patients.
   Methods. Demographic, clinical, health-related variables and cognitive scores measured with the Cambridge Neuropsychological Test Automated Battery (CANTAB) were compared between 74 patients with current MDD and 68 healthy controls (HC). To test the hypothesis of associated factors to cognitive symptoms, multivariate backward stepwise linear regression models were run.
   Results. Significant neuropsychological deficits were evident in MDD compared with HC in the global cognitive index (F=8.29; df=1, 140; p=0.005). In the regression analysis performed on MDD and HC, years of schooling (beta=-0.11; p=<0.001), job status (beta=-0.50; p=0.016), physical activity (beta=-0.25; p=0.04) and age at illness onset (beta=0.17; p=0.017) were statistically significant factors associated to cognitive impairment. The regression model ran in HC showed that only years of schooling were significant (beta=-0.07; p=<0.001) in this group.
   Limitations. Sample size was relatively small. Everyday cognitive skills were not evaluated.
   Conclusions. MDD patients have cognitive deficits. These deficits are linked with the years of education, job status, age of onset of the disease and the performance of physical activity. These results support the importance of the implementation of interventions targeting the cognitive reserve and lifestyle habits of MDD patients, in addition to the conventional therapeutic approach focused on symptoms control.
C1 [Sanchez-Carro, Yolanda; Leal-Leturia, Itziar; Lopez-Garcia, Pilar] Univ Autonoma Madrid, Dept Psychiat, Madrid, Spain.
   [Sanchez-Carro, Yolanda; Leal-Leturia, Itziar; Toll, Alba; Lopez-Garcia, Pilar] Inst Invest Sanitaria Princesa IIS Princesa, Dept Psychiat, La Princesa, Spain.
   [Sanchez-Carro, Yolanda; Portella, Maria J.; Leal-Leturia, Itziar; Urretavizcaya, Mikel; Alvarez, Pilar; Soria, Virginia; Lopez-Garcia, Pilar] Carlos III Hlth Inst, Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain.
   [Portella, Maria J.] Univ Autonoma Barcelona UAB, Biomed Res Inst St Pau IIB St Pau, Catalonia, Spain.
   [Salvat-Pujol, Neus; Etxandi, Mikel; de Arriba-Arnau, Aida; Urretavizcaya, Mikel; Soria, Virginia] Bellvitge Univ Hosp, Psychiat Dept Bellvitge Biomed Res Inst IDIBELL, Neurosci Grp, Psychiat & Mental Hlth, Barcelona, Spain.
   [Urretavizcaya, Mikel; Soria, Virginia] Univ Barcelona, Sch Med, Dept Clin Sci, Barcelona, Spain.
   [Pousa, Esther] Hosp Santa Creu & Sant Pau, Serv Psiquiatria, Barcelona, Spain.
   [Alvarez, Pilar] Hosp del Mar, IMIM, Inst Neuropsychiat & Addict, Barcelona, Spain.
C3 Autonomous University of Madrid; CIBER - Centro de Investigacion
   Biomedica en Red; CIBERSAM; Autonomous University of Barcelona; Institut
   d'Investigacio Biomedica de Bellvitge (IDIBELL); Bellvitge University
   Hospital; University of Barcelona; University of Barcelona; Hospital of
   Santa Creu i Sant Pau; Hospital del Mar Research Institute; Hospital del
   Mar
RP Sánchez-Carro, Y (corresponding author), Univ Autonoma Madrid, Sch Med, Dept Psychiat, 4 Arzobispo Morcillo St, Madrid 28029, Spain.
EM yolanda.sanchezc@uam.es
RI Salvat-Pujol, Neus/AAQ-5028-2020; Alvarez, Pilar/JAC-0258-2023; Sanchez
   Carro, Yolanda/AAC-9898-2022; Lopez-Garcia, Pilar/F-5934-2013; Pousa,
   Esther/AAJ-1267-2020; Portella, Maria/H-5909-2019; Toll,
   Alba/O-1512-2015
OI Etxandi, Mikel/0000-0002-5924-8495; Pousa, Esther/0000-0003-4423-6739;
   Sanchez, Yolanda/0000-0002-8644-9436; Portella, Maria
   J/0000-0002-2007-9516; Toll, Alba/0000-0003-2399-5250; Soria,
   Virginia/0000-0001-6412-6831; Alvarez, Pilar/0000-0002-6648-3493;
   Salvat-Pujol, Neus/0000-0001-5320-331X
FU Carlos III Health Institute through the Ministry of Science, Innovation
   and Universities [PI15/00662, PI15/0039, PI15/00204]; European Regional
   Development Fund (ERDF) "A way to build Europe"; CIBERSAM; Catalan
   Agency for the Management of University and Research Grants (AGAUR)
   [2017 SGR 1247]; Miguel Servet II from the Carlos III Health Institute
   through the Spanish Ministry of Health [CP16/00020]; FPI predoctoral
   grant from Universidad Autonoma de Madrid
FX This study was supported in part by grants from the Carlos III Health
   Institute through the Ministry of Science, Innovation and Universities
   (PI15/00662, PI15/0039, PI15/00204), co-funded by the European Regional
   Development Fund (ERDF) "A way to build Europe", CIBERSAM, and the
   Catalan Agency for the Management of University and Research Grants
   (AGAUR 2017 SGR 1247). We also thank CERCA Programme/Generalitat de
   Catalunya for institutional support. The funders had no role in the
   study design, data collection and analysis, decision to publish, or
   preparation of the manuscript. MJP is funded with a Miguel Servet II
   contract (CP16/00020) from the Carlos III Health Institute through the
   Spanish Ministry of Health. YSC work is supported by the FPI predoctoral
   grant (FPI 2016/17) from Universidad Autonoma de Madrid.
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NR 81
TC 15
Z9 16
U1 0
U2 22
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD JAN 15
PY 2021
VL 279
BP 343
EP 352
DI 10.1016/j.jad.2020.10.032
PG 10
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA PH8UQ
UT WOS:000600680800043
PM 33099048
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Matricciani, L
   Paquet, C
   Galland, B
   Short, M
   Olds, T
AF Matricciani, Lisa
   Paquet, Catherine
   Galland, Barbara
   Short, Michelle
   Olds, Tim
TI Children's sleep and health: A meta-review
SO SLEEP MEDICINE REVIEWS
LA English
DT Review
DE Sleep; Children; Health
ID CHILDHOOD OBESITY; SYSTEMATIC REVIEWS; DURATION; ADOLESCENTS;
   METAANALYSIS; RISK; DEPRESSION
AB Sleep is essential for children's health and well-being. Characteristics of children's sleep such as sleep duration, timing, quality and variability are increasingly being associated with a wide range of health outcomes. The purpose of this study is to conduct a meta-review (systematic review of systematic reviews) to examine the relationship between sleep and health in children. A systematic search of four electronic databases (Medline, Psychlnfo, Scopus, and Embase) was conducted to identify systematic reviews that examine the association between characteristics of children's sleep and health. Key findings, as well as areas in need of further research were synthesised descriptively. A total of 39 systematic reviews were identified for inclusion, covering areas of cognition, psychosocial health, cardiometabolic health, adiposity and other outcomes such as musculoskeletal pain. There is substantial and consistent evidence relating sleep duration to adiposity and emotional outcomes. The relationships between sleep quality and timing and blood lipids and glycaemic control merit further research. Links between sleep and metabolic syndrome in children appear to be weak and inconsistent. Key areas identified in need for further research included studies that objectively assess children's sleep and move beyond cross-sectional study designs and consider characteristics of sleep other than duration. It was also noted that covariates applied across studies varied considerably and the issue of residual confounding was raised in a number of reviews. Lastly, all reviews reported studies adopted a traditional approach of examining only one aspect of children's sleep. Systematic reviews support the notion that sleep is important for children's health. However, further studies that objectively assess sleep and consider characteristics of sleep other than duration and outcomes other than adiposity are needed. An under-standing of sleep as a multidimensional construct and as a component of the 24-h d, is also needed to better understand the relationship between sleep and health in children. (C) 2019 Elsevier Ltd. All rights reserved.
C1 [Matricciani, Lisa; Olds, Tim] Univ South Australia, ARENA, Adelaide, SA, Australia.
   [Matricciani, Lisa; Olds, Tim] Murdoch Childrens Res Inst, Melbourne, Vic, Australia.
   [Paquet, Catherine] Univ South Australia, Sch Hlth Sci, Australian Ctr Precis Hlth, UniSA Canc Res Inst, Adelaide, SA, Australia.
   [Galland, Barbara] Univ Otago, Dept Womens & Childrens Hlth, Dunedin, New Zealand.
   [Short, Michelle] Flinders Univ S Australia, Sch Psychol, Adelaide, SA, Australia.
C3 University of South Australia; Murdoch Children's Research Institute;
   University of South Australia; University of Otago; Flinders University
   South Australia
RP Matricciani, L (corresponding author), Univ South Australia, Sch Hlth Sci, Adelaide, SA 5000, Australia.
EM Matla005@mymail.unisa.edu.au
RI Matricciani, Lisa/AFP-0187-2022; Short, Michelle/E-9924-2013; Olds,
   Tim/A-1223-2008; Paquet, Catherine/C-3894-2009
OI Olds, Tim/0000-0001-6894-5519; Paquet, Catherine/0000-0002-6877-7903;
   Matricciani, Lisa/0000-0002-4480-4188
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   [No title captured]
NR 50
TC 266
Z9 289
U1 16
U2 106
PU W B SAUNDERS CO LTD
PI LONDON
PA 32 JAMESTOWN RD, LONDON NW1 7BY, ENGLAND
SN 1087-0792
EI 1532-2955
J9 SLEEP MED REV
JI Sleep Med. Rev.
PD AUG
PY 2019
VL 46
BP 136
EP 150
DI 10.1016/j.smrv.2019.04.011
PG 15
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology
GA IE6QV
UT WOS:000472501700013
PM 31121414
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Moran, LJ
   Ko, H
   Misso, M
   Marsh, K
   Noakes, M
   Mac Talbot
   Frearson, M
   Thondan, M
   Stepto, N
   Teede, HJ
AF Moran, Lisa J.
   Ko, Henry
   Misso, Marie
   Marsh, Kate
   Noakes, Manny
   Mac Talbot
   Frearson, Meredith
   Thondan, Mala
   Stepto, Nigel
   Teede, Helena J.
TI Dietary Composition in the Treatment of Polycystic Ovary Syndrome: A
   Systematic Review to Inform Evidence-Based Guidelines
SO JOURNAL OF THE ACADEMY OF NUTRITION AND DIETETICS
LA English
DT Review
DE Polycystic ovary syndrome; Weight management; Lifestyle interventions;
   Dietary composition
ID WEIGHT-LOSS DIETS; IMPAIRED GLUCOSE-TOLERANCE; QUALITY-OF-LIFE; LOW-FAT
   DIETS; LOW-CARBOHYDRATE; GLYCEMIC INDEX; HIGH-PROTEIN;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; RISK-FACTORS
AB While lifestyle management is recommended as first-line treatment of polycystic ovary syndrome (PCOS), the optimal dietary composition is unclear. The aim of this study was to compare the effect of different diet compositions on anthropometric, reproductive, metabolic, and psychological outcomes in PCOS. A literature search was conducted (Australasian Medical Index, CINAHL, EMBASE, Medline, PsycInfo, and EBM reviews; most recent search was performed January 19, 2012). Inclusion criteria were women with PCOS not taking anti-obesity medications and all weight-loss or maintenance diets comparing different dietary compositions. Studies were assessed for risk of bias. A total of 4,154 articles were retrieved and six articles from five studies met the a priori selection criteria, with 137 women included. A meta-analysis was not performed due to clinical heterogeneity for factors including participants, dietary intervention composition, duration, and outcomes. There were subtle differences between diets, with greater weight loss for a monounsaturated fat-enriched diet; improved menstrual regularity for a low-glycemic index diet; increased free androgen index for a high-carbohydrate diet; greater reductions in insulin resistance, fibrinogen, total, and high-density lipoprotein cholesterol for a low-carbohydrate or low-glycemic index diet; improved quality of life for a low-glycemic index diet; and improved depression and self-esteem for a high-protein diet. Weight loss improved the presentation of PCOS regardless of dietary composition in the majority of studies. Weight loss should be targeted in all overweight women with PCOS through reducing caloric intake in the setting of adequate nutritional intake and healthy food choices irrespective of diet composition. J Acad Nutr Diet. 2013;113:520-545.
C1 [Moran, Lisa J.] Univ Adelaide, Discipline Obstet & Gynaecol, Robinson Inst, Adelaide, SA 5006, Australia.
   [Moran, Lisa J.; Misso, Marie; Stepto, Nigel; Teede, Helena J.] Monash Univ, Monash Med Ctr, Sch Publ Hlth & Prevent Med, Clayton, Vic, Australia.
   [Ko, Henry] Southern Hlth, Monash Med Ctr, Ctr Clin Effectiveness, Clayton, Vic 3168, Australia.
   [Ko, Henry] SingHealth, Ctr Hlth Serv Res, Singapore, Singapore.
   [Marsh, Kate] Dietitians Assoc Australia Accredited Practicing, Chatswood, NSW, Australia.
   [Noakes, Manny] CSIRO Hlth Sci & Nutr, Adelaide, SA, Australia.
   [Mac Talbot] Healthbridge Hawthorn Private Hosp, Monash IVF, Hawthorn, Vic, Australia.
   [Frearson, Meredith] Adelaide Hlth Care, Adelaide, SA, Australia.
   [Thondan, Mala] Harp Family Med, East Kew, Vic, Australia.
   [Stepto, Nigel] Inst Sport & Exercise Act Living, Melbourne, Vic, Australia.
   [Stepto, Nigel] Sch Sport & Exercise Sci, Melbourne, Vic, Australia.
   [Teede, Helena J.] Southern Hlth, Monash Med Ctr, Diabet Unit, Clayton, Vic, Australia.
C3 University of Adelaide; Robinson Research Institute; Monash Health;
   Monash Medical Centre; Monash University; Monash Health; Monash Medical
   Centre; Monash University; Commonwealth Scientific & Industrial Research
   Organisation (CSIRO); Health Sciences & Nutrition; Monash University;
   Monash Health; Monash Medical Centre
RP Moran, LJ (corresponding author), Univ Adelaide, Sch Paediat & Reprod Hlth, Robinson Inst, Res Ctr Reprod Hlth, 55 King William Rd, Adelaide, SA 5006, Australia.
EM lisa.moran@adelaide.edu.au
RI noakes, manny/H-2813-2013; Moran, Lisa/E-9850-2015
OI Stepto, Nigel/0000-0002-0875-6836; Teede, Helena/0000-0001-7609-577X;
   Moran, Lisa/0000-0001-5772-6484
FU Australian Government Department of Health and Ageing, through the Jean
   Hailes for Women's Health on behalf of the PCOS Australian Alliance
FX The preparation of this manuscript was funded within the development and
   translation of the Evidence Based Guideline for the Assessment and
   Diagnosis of PCOS (PCOS Australian Alliance, 2011) by the Australian
   Government Department of Health and Ageing, through the Jean Hailes for
   Women's Health on behalf of the PCOS Australian Alliance. This
   manuscript is editorially independent. The funders, the Australian
   Government Department of Health and Ageing, were not involved in the
   preparation of this manuscript or development of the guideline and have
   not influenced the scope or conclusions herein.
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NR 62
TC 164
Z9 175
U1 1
U2 72
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 2212-2672
EI 2212-2680
J9 J ACAD NUTR DIET
JI J. Acad. Nutr. Diet.
PD APR
PY 2013
VL 113
IS 4
BP 520
EP 545
DI 10.1016/j.jand.2012.11.018
PG 26
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 121PS
UT WOS:000317257300008
PM 23420000
DA 2025-06-11
ER

PT J
AU Wang, Y
   Wang, XM
   Chen, Y
   Zhang, YL
   Zhen, XJ
   Tao, SY
   Dou, JF
   Li, P
   Jiang, GJ
AF Wang, Yan
   Wang, Xianmin
   Chen, Yang
   Zhang, Yuelin
   Zhen, Xianjie
   Tao, Siyu
   Dou, Jinfang
   Li, Peng
   Jiang, Guangjian
TI Perivascular fat tissue and vascular aging: A sword and a shield
SO PHARMACOLOGICAL RESEARCH
LA English
DT Article
DE Vascular aging; Perivascular adipose tissue; Cardiovascular and
   cerebrovascular diseases; Inflammatory response
ID ADIPOSE-TISSUE; METABOLIC SYNDROME; EXPRESSION; ADIPONECTIN; WHITE;
   BROWN; THERMOGENESIS; INFLAMMATION; DYSFUNCTION; ADIPOCYTES
AB The understanding of the function of perivascular adipose tissue (PVAT) in vascular aging has significantly changed due to the increasing amount of information regarding its biology. Adipose tissue surrounding blood vessels is increasingly recognized as a key regulator of vascular disorders. It has significant endocrine and paracrine effects on the vasculature and is mediated by the production of a variety of bioactive chemicals. It also participates in a number of pathological regulatory processes, including oxidative stress, immunological inflammation, lipid metabolism, vasoconstriction, and dilation. Mechanisms of homeostasis and interactions between cells at the local level tightly regulate the function and secretory repertoire of PVAT, which can become dysregulated during vascular aging. The PVAT secretion group changes from being reducing inflammation and lowering cholesterol to increasing inflammation and increasing cholesterol in response to systemic or local inflammation and insulin resistance. In addition, the interaction between the PVAT and the vasculature is reciprocal, and the biological processes of PVAT are directly influenced by the pertinent indicators of vascular aging. The architectural and biological traits of PVAT, the molecular mechanism of crosstalk between PVAT and vascular aging, and the clinical correlation of vascular age-related disorders are all summarized in this review. In addition, this paper aims to elucidate and evaluate the potential benefits of therapeutically targeting PVAT in the context of mitigating vascular aging. Furthermore, it will discuss the latest advancements in technology used for targeting PVAT.
C1 [Wang, Yan; Zhang, Yuelin; Zhen, Xianjie; Tao, Siyu; Dou, Jinfang; Jiang, Guangjian] Beijing Univ Chinese Med, Sch Tradit Chinese Med, Beijing 100029, Peoples R China.
   [Wang, Xianmin; Li, Peng] Xinjiang Uygur Autonomous Reg Hosp Tradit Chinese, Urumqi 830000, Xinjiang, Peoples R China.
   [Chen, Yang; Jiang, Guangjian] Xinjiang Med Univ, Sch Tradit Chinese Med, Urumqi 830011, Xinjiang, Peoples R China.
C3 Beijing University of Chinese Medicine; Xinjiang Medical University
RP Jiang, GJ (corresponding author), Beijing Univ Chinese Med, Sch Tradit Chinese Med, Beijing 100029, Peoples R China.
EM bucmjiang@163.com
RI Tao, Siyu/Y-2442-2019
FU National Natural Science Foundation of China [82260931, 2023B03002];
   Urumqi Science and Technology Plan Project [Y151310014]
FX This work was funded by grants from the National Natural Science
   Foundation of China (No. 82260931) , 2023 Xinjiang Uygur Autonomous
   Region key research and Development task Special named "Research on
   evidence-based evaluation, key techniques and formulation of
   charac-teristic prescriptions of TCM for the prevention and treatment of
   dia-betic microangiopathopathy" (No. 2023B03002) and Urumqi Science and
   Technology Plan Project (No. Y151310014) .
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NR 129
TC 3
Z9 3
U1 6
U2 15
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 1043-6618
EI 1096-1186
J9 PHARMACOL RES
JI Pharmacol. Res.
PD MAY
PY 2024
VL 203
AR 107140
DI 10.1016/j.phrs.2024.107140
EA MAR 2024
PG 11
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA C8T0F
UT WOS:001292023600001
PM 38513826
OA hybrid
DA 2025-06-11
ER

PT J
AU Sidor, A
   Drozdzynska, A
   Gramza-Michalowska, A
AF Sidor, Andrzej
   Drozdzynska, Agnieszka
   Gramza-Michalowska, Anna
TI Black chokeberry (Aronia melanocarpa) and its products as
   potential health-promoting factors - An overview
SO TRENDS IN FOOD SCIENCE & TECHNOLOGY
LA English
DT Review
DE Black chokeberry; Aronia melanocarpa; Polyphenols; Health benefits
ID DIPEPTIDYL PEPTIDASE IV; BREAST-CANCER PATIENTS; BLOOD-PRESSURE;
   OXIDATIVE STRESS; ANTIOXIDANT ACTIVITY; COMMERCIAL EXTRACT; JUICE
   CONSUMPTION; LIPID STATUS; RISK-FACTORS; BERRY
AB Background: Black chokeberry fruits (Aronia melnocarpa) are used in the food industry for the production of juices, preserves, tinctures, fruit teas and dietary supplements. Fresh, unprocessed black chokeberry fruits however are rarely consumed due to their bitter taste, resulting from the presence of a significant amount of polyphenols. Polyphenols are biofactors that determine the high activity of black chokeberries, including proanthocyanidins, anthocyanins, phenolic acids, flavonols, and flavanols. Black chokeberry fruit and products have great health-promoting potential as they reduce the risk factors of the metabolic syndrome. Many studies showed the beneficial effects of black chokeberries in frequent co-morbidities such as dyslipidaemia, hypertension, obesity, glucose metabolism disorders, proinflammatory conditions and thrombosis risk. Black chokeberry has the probable potential to inhibit the development of various types of cancers, including leukaemia, breast and intestinal cancer as well as cancer stem cells.
   Scope and approach: This publication reviewed the scientific research regarding the health benefits of black chokeberry fruits and isolated compounds. These findings may be essential in future research with regard to black chokeberry based functional food products.
   Key findings and conclusions: Black chokeberry can be considered as promising component of novel food with increased biological potential. However, like other highly bioactive plants and products of natural origin, black chokeberry requires wide-ranging studies on humans to determine its safety, efficacy, as well as mechanisms of action.
C1 [Sidor, Andrzej; Drozdzynska, Agnieszka; Gramza-Michalowska, Anna] Univ Life Sci Poznan, Fac Food Sci & Nutr, Poznan, Poland.
C3 Poznan University of Life Sciences
RP Gramza-Michalowska, A (corresponding author), Univ Life Sci Poznan, Fac Food Sci & Nutr, Poznan, Poland.
EM anna.gramza@up.poznan.pl
RI Drożdżyńska, Agnieszka/AAD-4573-2019; Gramza-Michałowska,
   Anna/Z-1601-2018
OI Sidor, Andrzej/0000-0001-9844-431X; Drozdzynska,
   Agnieszka/0000-0002-4580-354X
FU Ministry of Science and Higher Education programme [005/RID/2018/19]
FX The language correction was financed within the framework of Ministry of
   Science and Higher Education programme as "Regional Initiative
   Excellence" in years 2019-2022, project number 005/RID/2018/19.
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NR 106
TC 102
Z9 111
U1 6
U2 157
PU ELSEVIER SCIENCE LONDON
PI LONDON
PA 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND
SN 0924-2244
J9 TRENDS FOOD SCI TECH
JI Trends Food Sci. Technol.
PD JUL
PY 2019
VL 89
BP 45
EP 60
DI 10.1016/j.tifs.2019.05.006
PG 16
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA IE7YJ
UT WOS:000472590600004
DA 2025-06-11
ER

PT J
AU Pawelczyk, T
   Trafalska, E
   Pawelczyk, A
   Kotlicka-Antczak, M
AF Pawelczyk, Tomasz
   Trafalska, Elzbieta
   Pawelczyk, Agnieszka
   Kotlicka-Antczak, Magdalena
TI Differences in omega-3 and omega-6 polyunsaturated fatty acid
   consumption in people at ultra-high risk of psychosis, first-episode
   schizophrenia, and in healthy controls
SO EARLY INTERVENTION IN PSYCHIATRY
LA English
DT Article
DE at-risk mental state; diet survey; omega-3 fatty acid; omega-6 fatty
   acid; schizophrenia first episode
ID DRUG-NAIVE PATIENTS; LIFE-STYLE; PREFRONTAL CORTEX; COMPREHENSIVE
   ASSESSMENT; DOCOSAHEXAENOIC ACID; CARDIOVASCULAR RISK; METABOLIC
   SYNDROME; GENETIC-VARIATION; BIPOLAR DISORDER; OXIDATIVE STRESS
AB AimSupplementation with omega-3 PUFA showed efficacy in reducing the risk of transition into psychosis in UHR individuals. It is uncertain whether dietary patterns can be partly responsible for n-3 deficiencies observed in susceptible participants before the diagnosis of schizophrenia. The study was designed to assess differences in omega-3 and omega-6 PUFA consumption in healthy controls (HC), UHR participants and FES patients as well as to verify the hypothesis that dietary changes in PUFA consumption are present before active psychosis develops, that is, in UHR individuals.
   MethodsDietary habits during the previous year were assessed in 34 patients at UHR of psychosis, 33 patients diagnosed with FES and 33 HC participants using a validated Food-Frequency Questionnaire and the Polish Food Composition Tables.
   ResultsSignificant differences in omega-3 and omega-6 PUFA intake were observed between study groups. UHR and FES groups reported significantly higher consumption of omega-6 PUFA in comparison with HC. FES patients also reported a higher consumption of alpha-linolenic acid (omega-3) in comparison with HC. No significant differences were seen in consumption of long-chain marine PUFA.
   ConclusionsDifferences in omega-6 and omega-3 PUFA consumption exist before development of psychotic symptoms, fulfilling the criteria of schizophrenia.
C1 [Pawelczyk, Tomasz; Pawelczyk, Agnieszka; Kotlicka-Antczak, Magdalena] Med Univ Lodz, Dept Affect & Psychot Disorders, Czechoslowacka 8-10, PL-92216 Lodz, Poland.
   [Trafalska, Elzbieta] Med Univ Lodz, Dept Nutr Hyg & Epidemiol, Lodz, Poland.
C3 Medical University Lodz; Medical University Lodz
RP Pawelczyk, T (corresponding author), Med Univ Lodz, Dept Affect & Psychot Disorders, Czechoslowacka 8-10, PL-92216 Lodz, Poland.
EM tomasz.pawelczyk@umed.lodz.pl
RI Pawełczyk, Tomasz/S-9266-2016; Pawełczyk, Agnieszka/N-9039-2019;
   Pawelczyk, Agnieszka/S-9524-2016
OI Kotlicka-Antczak, Magdalena/0000-0001-5755-6198; Trafalska,
   Elzbieta/0000-0002-1937-0090; Pawelczyk, Agnieszka/0000-0003-1900-0214
FU Polish National Science Center [N N402 243435]
FX This paper was supported by the Grant No. N N402 243435 obtained from
   the Polish National Science Center. We would like to express our
   gratitude to psychiatrists practicing in Lodz and the region for
   referring patients to the PORT center. The authors would like to express
   their special thanks to Prof. Jolanta Rabe-Jabonska MD, PhD the former
   head of the department who was deeply involved in study preparation, and
   who unfortunately died in May 2014.
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NR 82
TC 10
Z9 10
U1 2
U2 23
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1751-7885
EI 1751-7893
J9 EARLY INTERV PSYCHIA
JI Early Interv. Psychiatry
PD DEC
PY 2017
VL 11
IS 6
BP 498
EP 508
DI 10.1111/eip.12267
PG 11
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA FM8MJ
UT WOS:000415342400006
PM 26279283
DA 2025-06-11
ER

PT J
AU Ghasemi, A
   Jeddi, S
AF Ghasemi, Asghar
   Jeddi, Sajad
TI Anti-obesity and anti-diabetic effects of nitrate and nitrite
SO NITRIC OXIDE-BIOLOGY AND CHEMISTRY
LA English
DT Review
DE Nitric oxide; Nitrate; Nitrite; Obesity; Type 2 diabetes; Insulin
ID TYPE-2 DIABETES-MELLITUS; BEETROOT JUICE SUPPLEMENTATION; STIMULATED
   INSULIN-SECRETION; DIETARY INORGANIC NITRATE; REDUCES BLOOD-PRESSURE;
   THYROID-GLAND ACTIVITY; ORAL SODIUM-NITRITE; OXIDE SYNTHASE; METABOLIC
   SYNDROME; ADIPOSE-TISSUE
AB Prevalence of obesity is increasing worldwide and type 2 diabetes to date is the most devastating complication of obesity. Decreased nitric oxide bioavailability is a feature of obesity and diabetes that links these two pathologies. Nitric oxide is synthesized both by nitric oxide synthase enzymes from L-arginine and nitric oxide synthase-independent from nitrate/nitrite. Nitric oxide production from nitrate/nitrite could potentially be used for nutrition-based therapy in obesity and diabetes. Nitric oxide deficiency also contributes to pathogeneses of cardiovascular disease and hypertension, which are associated with obesity and diabetes. This review summarizes pathways for nitric oxide production and focuses on the anti-diabetic and anti-obesity effects of the nitrate-nitrite-nitric oxide pathway. In addition to increasing nitric oxide production, nitrate and nitrite reduce oxidative stress, increase adipose tissue browning, have favorable effects on nitric oxide synthase expression, and increase insulin secretion, all effects that are potentially promising for management of obesity and diabetes. Based on current data, it could be suggested that amplifying the nitrate nitrite nitric oxide pathway is a diet-based strategy for increasing nitric oxide bioavailability and the management of these two interlinked conditions. Adding nitrate/nitrite to drugs that are currently used for managing diabetes (e.g. metformin) and possibly anti obesity drugs may also enhance their efficacy. (C) 2017 Elsevier Inc. All rights reserved.
C1 [Ghasemi, Asghar; Jeddi, Sajad] Shahid Beheshti Univ Med Sci, Res Inst Endocrine Sci, Endocrine Physiol Res Ctr, 24 Parvaneh St,POB 19395-4763, Tehran, Iran.
C3 Shahid Beheshti University Medical Sciences
RP Ghasemi, A (corresponding author), Shahid Beheshti Univ Med Sci, Res Inst Endocrine Sci, Endocrine Physiol Res Ctr, 24 Parvaneh St,POB 19395-4763, Tehran, Iran.
EM Ghasemi@endocrine.ac.ir
RI Jeddi, Sajad/U-8493-2019; Ghasemi, Asghar/O-4145-2017
OI Jeddi, Sajad/0000-0002-3911-6620; Ghasemi, Asghar/0000-0001-6867-2151
FU Research Institute for Endocrine Sciences, Shahid Beheshti University of
   Medical Sciences, Tehran, Iran [766]
FX The authors wish to acknowledge Ms Niloofar Shiva for critical editing
   of English grammar and syntax of the manuscript. This work was supported
   by Research Institute for Endocrine Sciences, Shahid Beheshti University
   of Medical Sciences (grant number 766), Tehran, Iran. The authors have
   no conflict of interest to disclose.
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TC 66
Z9 72
U1 3
U2 22
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 1089-8603
EI 1089-8611
J9 NITRIC OXIDE-BIOL CH
JI Nitric Oxide-Biol. Chem.
PD NOV 1
PY 2017
VL 70
BP 9
EP 24
DI 10.1016/j.niox.2017.08.003
PG 16
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA FL0GA
UT WOS:000413888400002
PM 28804022
DA 2025-06-11
ER

PT J
AU Buraczynska, M
   Wacinski, P
   Zukowski, P
   Dragan, M
   Ksiazek, A
AF Buraczynska, Monika
   Wacinski, Piotr
   Zukowski, Pawel
   Dragan, Michal
   Ksiazek, Andrzej
TI Common polymorphism in the cannabinoid type 1 receptor gene (CNR1) is
   associated with microvascular complications in type 2 diabetes
SO JOURNAL OF DIABETES AND ITS COMPLICATIONS
LA English
DT Article
DE Diabetic nephropathy; Diabetic retinopathy; Gene polymorphism; Risk
   allele; Type 2 diabetes
ID GENOME-WIDE ASSOCIATION; CORONARY-ARTERY-DISEASE; G1359A POLYMORPHISM;
   ENDOCANNABINOID SYSTEM; METABOLIC SYNDROME; OXIDATIVE STRESS; EMERGING
   ROLE; CB1 GENE; RETINOPATHY; RISK
AB Endocannabinoids exert their biological effects via interaction with G-protein coupled cannabinoid receptors CBI and CB2. Polymorphisms in the CNR1 gene (encoding CBI receptor) were previously found to be associated with dyslipidemia and cardiovascular diseases. We investigated a role of the polymorphism in CNR1 gene in type 2 diabetes and its complications. The study involved 667 T2DM patients and 450 healthy individuals. All subjects were genotyped for G1359A polymorphism by PCR-RFLP procedure. Genotype frequencies did not differ significantly between patients and controls. The statistically significant differences were seen between T2DM patients with diabetic nephropathy (DN) and those without it (OR for risk allele 2.84, 95% CI 2.04-3.94, p < 0.0001). There were also differences between patients with diabetic retinopathy (DR) and those without DR (OR for risk allele 1.81, 95% CI 1.30-2.53, p = 0.0005). No differences were observed in diabetic neuropathy. The A allele was more frequent in patients with coexisting cardiovascular disease (CVD) compared to patients without CVD (p = 0.0044). The novel finding of our study is the association of the G1359A polymorphism with diabetic nephropathy and diabetic retinopathy in patients with T2DM. This polymorphism was also associated with cardiovascular disease in the patient group. (C) 2014 Elsevier Inc. All rights reserved.
C1 [Buraczynska, Monika; Zukowski, Pawel; Dragan, Michal; Ksiazek, Andrzej] Med Univ Lublin, Dept Nephrol, Lab DNA Anal & Mol Diagnost, PL-20954 Lublin, Poland.
   [Wacinski, Piotr] Med Univ Lublin, Dept Cardiol, PL-20954 Lublin, Poland.
C3 Medical University of Lublin; Medical University of Lublin
RP Buraczynska, M (corresponding author), Med Univ Lublin, Dept Nephrol, Lab DNA Anal & Mol Diagnost, PL-20954 Lublin, Poland.
EM monika.buraczynska@umlub.pl
RI Wacinski, Piotr/HOF-1925-2023
OI Dragan, Michal/0000-0002-5531-5363; Wacinski, Piotr/0000-0002-8537-8867
FU National Research Center [N N402 5229 40]
FX This study was supported by the grant from the National Research Center
   No. N N402 5229 40 (MB). The authors would like to thank Ms. Teresa
   Nowicka and Mr. Piotr Zukowski for technical assistance.
CR Barutta F, 2010, DIABETES, V59, P1046, DOI 10.2337/db09-1336
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   de Miguel-Yanes JM, 2011, OBESITY, V19, P2031, DOI 10.1038/oby.2011.135
   El-Remessy AB, 2011, DIABETOLOGIA, V54, P1567, DOI 10.1007/s00125-011-2061-4
   El-Remessy AB, 2006, AM J PATHOL, V168, P235, DOI 10.2353/ajpath.2006.050500
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NR 35
TC 18
Z9 21
U1 0
U2 7
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1056-8727
EI 1873-460X
J9 J DIABETES COMPLICAT
JI J. Diabetes Complications
PD JAN-FEB
PY 2014
VL 28
IS 1
BP 35
EP 39
DI 10.1016/j.jdiacomp.2013.08.005
PG 5
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 288DL
UT WOS:000329592100009
PM 24075694
DA 2025-06-11
ER

PT J
AU Shah, P
   Ardestani, A
   Dharmadhikari, G
   Laue, S
   Schumann, DM
   Kerr-Conte, J
   Pattou, F
   Klein, T
   Maedler, K
AF Shah, Payal
   Ardestani, Amin
   Dharmadhikari, Gitanjali
   Laue, Svenja
   Schumann, Desiree M.
   Kerr-Conte, Julie
   Pattou, Francois
   Klein, Thomas
   Maedler, Kathrin
TI The DPP-4 Inhibitor Linagliptin Restores β-Cell Function and Survival in
   Human Isolated Islets Through GLP-1 Stabilization
SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Article
ID DIPEPTIDYL PEPTIDASE-IV; RANDOMIZED CONTROLLED-TRIAL; HUMAN
   PANCREATIC-ISLETS; RECEPTOR EXPRESSION; METABOLIC SYNDROME; ALPHA-CELLS;
   BI 1356; GLUCOSE; APOPTOSIS; HYPERGLYCEMIA
AB Context: Inhibition of dipeptidyl peptidase-4 (DPP-4) is a potent strategy to increase glucose-dependent insulinotropic polypeptide and glucagon like peptide 1 (GLP-1) induced insulin secretion in diabetes. It is important to know whether new drugs approved for the treatment of type 2 diabetes have direct effects on the beta-cell. Objective: Herein we investigated the effect of linagliptin, a novel DPP-4 inhibitor, on beta-cell function and survival.
   Design: Human islets were exposed to a diabetic milieu (11.1-33.3mMglucose, 0.5 mM palmitate, the mixture of 2 ng/mL IL-1 beta + 1000 U/mL interferon-gamma, or 50 mu M H2O2) with or without 500 ng/mL IL-1 receptor antagonist (IL-1Ra) or 30-50 nM linagliptin.
   Results: Linagliptin restored beta-cell function and turnover, which was impaired when islets were exposed to elevated glucose, palmitate, cytokines, or H2O2. Pretreatment with IL-1Ra was similarly effective, except against H2O2 treatment. Nitrotyrosine concentrations in islet lysates, an indicator of oxidative stress, were highly elevated under diabetic conditions but not in islets treated with linagliptin or IL-1Ra. Linagliptin also reduced cytokine secretion and stabilized GLP-1 in islet supernatants.
   Conclusions: We show that the novel DPP-4 inhibitor linagliptin protected from gluco-, lipo-, and cytokine-toxicity and stabilized active GLP-1 secreted from human islets. This provides a direct GLP-1 mediated protective effect of linagliptin on beta-cell function and survival.
C1 [Shah, Payal; Ardestani, Amin; Dharmadhikari, Gitanjali; Laue, Svenja; Maedler, Kathrin] Univ Bremen, Ctr Biomol Interact Bremen, D-28359 Bremen, Germany.
   [Schumann, Desiree M.; Klein, Thomas] Boehringer Ingelheim Pharma GmbH Co KG, CardioMetabol Dis Res, D-88397 Biberach, Germany.
   [Kerr-Conte, Julie; Pattou, Francois] Univ Lille Nord France, INSERM, U859, F-59044 Lille, France.
C3 University of Bremen; Boehringer Ingelheim; Universite de Lille;
   Institut National de la Sante et de la Recherche Medicale (Inserm)
RP Maedler, K (corresponding author), Univ Bremen, Islet Biol Lab, Ctr Biomol Interact Bremen, Leobener Str NW2,Room B2080, D-28359 Bremen, Germany.
EM kmaedler@uni-bremen.de
RI Maedler, Kathrin/ABE-3022-2021; Jiao, Zicong/IUP-9467-2023; Pattou,
   Francois/O-6151-2017
OI Pattou, Francois/0000-0001-8388-3766; Schumann,
   Desiree/0000-0002-1172-7438; Ardestani, Amin/0000-0002-0685-8564;
   Maedler, Kathrin/0000-0002-7436-1197
FU German Research Foundation (DFG, Emmy Noether Programm) [MA4172/1-1];
   European Research Council; JDRF Award (European Consortium For Islet
   Transplantation Islet for Basic Research program) [31-2008-413]
FX This work was supported by the German Research Foundation (DFG, Emmy
   Noether Programm MA4172/1-1) and the European Research Council. We thank
   Jennifer Bergemann (Uni Bremen), Katja Thode, Julia Dennenmoser, and
   Annette Halder (Boehringer Ingelheim) for excellent technical
   assistance. Human islets were provided through the JDRF Award
   31-2008-413 (European Consortium For Islet Transplantation Islet for
   Basic Research program).
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NR 55
TC 79
Z9 86
U1 1
U2 10
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0021-972X
EI 1945-7197
J9 J CLIN ENDOCR METAB
JI J. Clin. Endocrinol. Metab.
PD JUL
PY 2013
VL 98
IS 7
BP E1163
EP E1172
DI 10.1210/jc.2013-1029
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 196MV
UT WOS:000322780600002
PM 23633194
OA Bronze
DA 2025-06-11
ER

PT J
AU Shi, L
   Liu, ZW
   Li, Y
   Gong, C
   Zhang, H
   Song, LJ
   Huang, CY
   Li, M
AF Shi Lei
   Liu Zhong Wu
   Li Yun
   Gong Cai
   Zhang Huan
   Song Li Juan
   Huang Cheng Yu
   Li Ming
TI The Prevalence of Nonalcoholic Fatty Liver Disease and its Association
   with Lifestyle/dietary Habits among University Faculty and Staff in
   Chengdu
SO BIOMEDICAL AND ENVIRONMENTAL SCIENCES
LA English
DT Article
DE NAFLD; Prevalence; Case-control study; Lifestyle/dietary habits
ID ENDOPLASMIC-RETICULUM STRESS; METABOLIC SYNDROME; INSULIN-RESISTANCE;
   RISK-FACTORS; LIPID-PEROXIDATION; PHYSICAL-ACTIVITY; STEATOHEPATITIS;
   MECHANISM; EPIDEMIOLOGY; PREDICTOR
AB Objective To investigate the prevalence of nonalcoholic fatty liver disease (NAFLD) in different university categories and its association with lifestyle/dietary habits.
   Methods A cross-sectional study was carried out on 9 378 faculty members and staff who participated in an annual health checkup at three universities selected by random cluster sampling. Demographic, anthropometric, biochemical indices and abdominal ultrasound measurements were collected. A nested case-control study was conducted with 200 NAFLD cases and 200 controls matched by gender, age (+/- 3 years), and university.
   Results The overall prevalence of NAFLD was 10.3% (13.7% in males and 6.8% in females). The prevalence was significantly higher in the science and engineering university (22.1%) than in the comprehensive universities with (6.4%) and without (10.9%) medical colleges. Obesity/overweight, hyperlipidemia, diabetes mellitus, and family history of NAFLD were independently associated with higher risk of NAFLD, as were frequent consumption of desserts and salty/spicy foods. Using nutritional supplements was a protective factor against NAFLD. Intake of coarse cereals, potatoes, vegetables, fruits, and milk was significantly lower, and intake of red meat, viscera, candies and pastries, cooking oil, and total energy was significantly higher in participants with NAFLD than in controls.
   Conclusion Science and engineering university faculty and staff are key targets for NAFLD prevention. NAFLD is closely associated with age, gender, university type, metabolic diseases, and lifestyle/dietary habits.
C1 [Shi Lei; Li Yun; Gong Cai; Zhang Huan; Huang Cheng Yu; Li Ming] Sichuan Univ, W China Sch Publ Hlth, Dept Nutr & Food Safety, Chengdu 610041, Sichuan, Peoples R China.
   [Liu Zhong Wu] Sichuan Univ, Univ Hosp, Chengdu 610065, Peoples R China.
   [Song Li Juan] SW Univ Nationality, Univ Hosp, Chengdu 610041, Peoples R China.
C3 Sichuan University; Sichuan University; Southwest Minzu University
RP Li, M (corresponding author), Sichuan Univ, W China Sch Publ Hlth, Dept Nutr & Food Safety, Chengdu 610041, Sichuan, Peoples R China.
EM ldmenchen@163.com
FU Fundamental Research Funds for the Central Universities of the Ministry
   of Education [2010SCU21002]; Key Technology R&D Program of Sichuan
   Province [09ZC1270-16]
FX This work was supported by the Fundamental Research Funds for the
   Central Universities of the Ministry of Education (2010SCU21002) and the
   Key Technology R&D Program of Sichuan Province (09ZC1270-16).
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   Zivkovic AM, 2007, AM J CLIN NUTR, V86, P285, DOI 10.1093/ajcn/86.2.285
NR 38
TC 60
Z9 65
U1 0
U2 14
PU CHINESE CENTER DISEASE CONTROL & PREVENTION
PI BEIJING
PA 155 CHANGBAI RD, CHANGPING DISTRICT, BEIJING, 102206, PEOPLES R CHINA
SN 0895-3988
J9 BIOMED ENVIRON SCI
JI Biomed. Environ. Sci.
PD AUG
PY 2012
VL 25
IS 4
BP 383
EP 391
DI 10.3967/0895-3988.2012.04.002
PG 9
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA 005YM
UT WOS:000308786000002
PM 23026517
DA 2025-06-11
ER

PT J
AU Gupta, S
   Knight, AG
   Gupta, S
   Keller, JN
   Bruce-Keller, AJ
AF Gupta, Sunita
   Knight, Alecia G.
   Gupta, Shruti
   Keller, Jeffrey N.
   Bruce-Keller, Annadora J.
TI Saturated long-chain fatty acids activate inflammatory signaling in
   astrocytes
SO JOURNAL OF NEUROCHEMISTRY
LA English
DT Article
DE brain inflammation; cytokines; dyslipidemia; obesity; reactive gliosis
ID DIET-INDUCED OBESITY; INSULIN-RESISTANCE; OXIDATIVE STRESS; TNF-ALPHA;
   NEURONAL PLASTICITY; ENDOTHELIAL-CELLS; NERVOUS-SYSTEM; RAT-BRAIN;
   CYTOKINES; EXPRESSION
AB This study describes the effects of long-chain fatty acids on inflammatory signaling in cultured astrocytes. Data show that the saturated fatty acid palmitic acid, as well as lauric acid and stearic acid, trigger the release of TNFa and IL-6 from astrocytes. Unsaturated fatty acids were unable to induce cytokine release from cultured astrocytes. Furthermore, the effects of palmitic acid on cytokine release require Toll-like receptor 4 rather than CD36 or Toll-like receptor 2, and do not depend on palmitic acid metabolism to palmitoyl-CoA. Inhibitor studies revealed that pharmacologic inhibition of p38 or p42/44 MAPK pathways prevents the pro-inflammatory effects of palmitic acid, whereas JNK and PI3K inhibition does not affect cytokine release. Depletion of microglia from primary astrocyte cultures using the lysosomotropic agent l-leucine methyl ester revealed that the ability of palmitic acid to trigger cytokine release is not dependent on the presence of microglia. Finally, data show that the essential ?-3 fatty acid docosahexaenoic acid acts in a dose-dependent manner to prevent the actions of palmitic acid on inflammatory signaling in astrocytes. Collectively, these data demonstrate the ability of saturated fatty acids to induce astrocyte inflammation in vitro. These data thus raise the possibility that high levels of circulating saturated fatty acids could cause reactive gliosis and brain inflammation in vivo, and could potentially participate in the reported adverse neurologic consequences of obesity and metabolic syndrome.
C1 [Gupta, Sunita; Knight, Alecia G.; Gupta, Shruti; Keller, Jeffrey N.; Bruce-Keller, Annadora J.] Louisiana State Univ Syst, Pennington Biomed Res Ctr, Baton Rouge, LA USA.
C3 Louisiana State University System; Louisiana State University;
   Pennington Biomedical Research Center
RP Bruce-Keller, AJ (corresponding author), Pennington Biomed Res Ctr LSU, Inflammat & Neurodegenerat Lab, 6400 Perkins Rd, Baton Rouge, LA 70808 USA.
EM annadora.bruce-keller@pbrc.edu
RI Keller, Jeffrey/N-1975-2017; Bruce-Keller, Annadora/N-1954-2017; gupta,
   shruti/IQR-5576-2023
OI keller, jeffrey/0000-0002-9892-7423
FU NIH [NS46267, AG05119]
FX The authors are grateful to Taryn Parino for expert technical
   assistance. This work was supported by grants from the NIH (NS46267 and
   AG05119). The authors have no competing financial or other conflicts of
   interest.
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NR 90
TC 254
Z9 279
U1 0
U2 26
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-3042
EI 1471-4159
J9 J NEUROCHEM
JI J. Neurochem.
PD MAR
PY 2012
VL 120
IS 6
BP 1060
EP 1071
DI 10.1111/j.1471-4159.2012.07660.x
PG 12
WC Biochemistry & Molecular Biology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Neurosciences & Neurology
GA 903JL
UT WOS:000301112500018
PM 22248073
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Oliveira, LD
   da Silva, LP
   da Silva, AI
   Magalhaes, CP
   de Souza, SL
   de Castro, RM
AF Oliveira, Lisiane dos Santos
   da Silva, Ligia Pereira
   da Silva, Aline Isabel
   Magalhaes, Carolina Peixoto
   de Souza, Sandra Lopes
   de Castro, Raul Manhaes
TI Effects of early weaning on the circadian rhythm and behavioral satiety
   sequence in rats
SO BEHAVIOURAL PROCESSES
LA English
DT Article
DE Behavioral satiety sequence; Circadian rhythm; Early weaning; Feeding
   behavior
ID METABOLIC SYNDROME; ADULT-RATS; PROLACTIN INHIBITION; LACTATION
   PROGRAMS; FEEDING-BEHAVIOR; MATERNAL-CARE; MESSENGER-RNA; STRESS; MICE;
   FOOD
AB The objective of this work was to study the effect of early weaning on circadian rhythm and the behavioral satiety sequence in adult rats. Male Wistar rat pups were weaned for separation from the mother at 15 (D15), 21 (D21) and 30 (D30) days old. Body weight and food intake was measured every 30 days until pups were 150 days old. At 90 days of age. the circadian rhythm of food intake was evaluated every 4 h for three days. Behavioral satiety was evaluated at 35 and 100 days of age. This work demonstrated that body weight and food intake were not altered, but the behavioral satiety sequence demonstrated that the D15 group delayed satiety compared with the D30 group at 100 days of age. In the circadian rhythm of the food intake study, early weaning (D15) changed food intake in the intermediary period of the light phase and in the intermediary period of the dark phase. In conclusion, our study showed that early weaning may alter the feeding behavior mainly in relation to satiety and the circadian rhythm of feeding. It is possible that the presence of other environmental stimuli during early weaning can cause hyperphagia and deregulate the mechanisms of homeostasis and body weight control. This study supports theories that depict insults during early life as determinants of chronic diseases. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Oliveira, Lisiane dos Santos; da Silva, Ligia Pereira; Magalhaes, Carolina Peixoto] Univ Fed Pernambuco, Ctr Acad Vitoria, BR-55608680 Vitoria De Santo Antao, PE, Brazil.
   [da Silva, Aline Isabel; de Souza, Sandra Lopes] Univ Fed Pernambuco, Dept Anat, Recife, PE, Brazil.
   [de Castro, Raul Manhaes] Univ Fed Pernambuco, Dept Nutr, Recife, PE, Brazil.
C3 Universidade Federal de Pernambuco; Universidade Federal de Pernambuco;
   Universidade Federal de Pernambuco
RP Oliveira, LD (corresponding author), Univ Fed Pernambuco, Ctr Acad Vitoria, Rua Alto Reservatorio S-N, BR-55608680 Vitoria De Santo Antao, PE, Brazil.
EM lisianenutricao@yahoo.com.br
RI Pereira da Silva, Lígia/CAG-5308-2022; de Castro, Raul/A-1635-2014
OI da Silva, Aline Isabel/0009-0005-1102-6155
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NR 55
TC 35
Z9 35
U1 0
U2 8
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0376-6357
J9 BEHAV PROCESS
JI Behav. Processes
PD JAN
PY 2011
VL 86
IS 1
BP 119
EP 124
DI 10.1016/j.beproc.2010.10.001
PG 6
WC Psychology, Biological; Behavioral Sciences; Zoology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Behavioral Sciences; Zoology
GA 715DR
UT WOS:000286861200016
PM 20974233
OA hybrid
DA 2025-06-11
ER

PT J
AU Ory, F
   Kiss, BL
   Zsidó, AN
   Teleki, SA
AF Ory, Fanni
   Kiss, Botond Laszlo
   Zsido, Andras Norbert
   Teleki, Szidalisz agnes
TI Conquering diabetes by overcoming psychological barriers and embracing
   health
SO SCIENTIFIC REPORTS
LA English
DT Article
DE Diabetes mellitus; Insulin resistance; Diabetes distress; Health
   empowerment; Motivation for healthy eating; Body responsiveness; Meaning
   in life
ID INSULIN-RESISTANCE; PATIENT EMPOWERMENT; METABOLIC SYNDROME; BEHAVIORS;
   MOTIVATION; LITERACY; ETIOLOGY; MELLITUS; ADULTS; DIET
AB Living with chronic conditions like diabetes mellitus (DM) or insulin resistance (IR) requires significant self-management, adding to daily life stressors. This stress, known as diabetes distress, along with health empowerment from proper diet and lifestyle, and motivation to eat healthily, greatly impacts quality of life and disease outcomes. Different patient subgroups (type 1 diabetic (T1DM), type 2 diabetic (T2DM), and insulin resistant (IR) individuals) face these challenges differently. This research aims to compare people with IR and DM to those without, and to compare IR, T1DM and T2DM subgroups on psychological factors. Data was collected via an online questionnaire from 746 participants (average age 37.5 years). Among them, 405 had IR (N = 177) or DM (Type 1: N = 116; Type 2: N = 112), and 341 were controls. Results showed that T2DM individuals scored lower than controls on Identified Regulation, Interoceptive Awareness, and Search for Meaning in Life, while the IR group had higher body-mind disconnection. T1DM individuals experienced the highest emotional distress due to the disease but the lowest distress from regular check-ups compared to T2DM and IR groups. The gradient boosting classification model indicated that IR and T1DM groups are homogeneous, whereas T2DM is heterogeneous, with significant within-group variation in disease experience and management. Despite similarities in daily life challenges, significant differences exist in disease experience among the groups. Individual characteristics of T2DM individuals further diversify their attitudes towards disease management.
C1 [Ory, Fanni; Kiss, Botond Laszlo; Zsido, Andras Norbert; Teleki, Szidalisz agnes] Univ Pecs, Inst Psychol, Fac Humanities & Social Sci, 6 Ifjusag St, H-7624 Pecs, Hungary.
   [Kiss, Botond Laszlo; Zsido, Andras Norbert] Univ Pecs, Szentagotha Res Ctr, Pecs, Hungary.
   [Zsido, Andras Norbert] Univ Pecs, Res Ctr Contemporary Challenges, Pecs, Hungary.
C3 University of Pecs; HUN-REN; HUN-REN Research Centre for Natural
   Sciences; Institute of Cognitive Neuroscience & Psychology - HAS;
   University of Pecs; University of Pecs
RP Ory, F (corresponding author), Univ Pecs, Inst Psychol, Fac Humanities & Social Sci, 6 Ifjusag St, H-7624 Pecs, Hungary.
EM ory.fanni@pte.hu
RI Kiss, Botond László/JMB-8762-2023; Zsido, Andras/AAC-6489-2019
OI Zsido, Andras/0000-0003-0506-6861; Kiss, Botond
   Laszlo/0000-0003-3545-6414; Teleki, Szidalisz/0000-0001-8382-1688
FU Innovcis s Technolgiai Minisztrium
FX F & Odblac; was supported by the & Uacute;NKP-23-3 New National
   Excellence Programs of the Ministry for Innovation and Technology from
   the source of the National Research, Development and Innovation Fund.
   ANZS was supported by the & Uacute;NKP-23-5 New National Excellence
   Programs of the Ministry for Innovation and Technology from the source
   of the National Research, Development and Innovation Fund. ANZS was also
   supported by OTKA PD 137588 and OTKA FK 146604 research grants. BLK
   received support from OTKA K 143254 research grant. ANZS was also
   supported by the Janos Bolyai Research Scholarship provided by the
   Hungarian Academy of Sciences
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NR 65
TC 0
Z9 0
U1 2
U2 2
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD DEC 30
PY 2024
VL 14
IS 1
AR 32104
DI 10.1038/s41598-024-83837-y
PG 15
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA Q7I6D
UT WOS:001386371500039
PM 39738997
OA gold
DA 2025-06-11
ER

PT J
AU Brown, K
   Theofanous, D
   Britton, RG
   Aburido, G
   Pepper, C
   Undru, SS
   Howells, L
AF Brown, Karen
   Theofanous, Despoina
   Britton, Robert G.
   Aburido, Grandezza
   Pepper, Coral
   Sri Undru, Shanthi
   Howells, Lynne
TI Resveratrol for the Management of Human Health: How Far Have We Come? A
   Systematic Review of Resveratrol Clinical Trials to Highlight Gaps and
   Opportunities
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE resveratrol; clinical trials; systematic review; nutraceuticals
ID FATTY LIVER-DISEASE; HIGH-DOSE RESVERATROL; TYPE-2 DIABETES-MELLITUS;
   RANDOMIZED DOUBLE-BLIND; TRANS-RESVERATROL; INSULIN SENSITIVITY; ORAL
   RESVERATROL; OXIDATIVE STRESS; SKELETAL-MUSCLE; GENE-EXPRESSION
AB Resveratrol has long been proposed as being beneficial to human health across multiple morbidities, yet there is currently no conclusive clinical evidence to advocate its recommendation in any healthcare setting. A large cohort with high-quality clinical data and clearly defined biomarkers or endpoints are required to draw meaningful conclusions. This systematic review compiles every clinical trial conducted using a defined dose of resveratrol in a purified form across multiple morbidities to highlight the current 'state-of-play' and knowledge gaps, informing future trial designs to facilitate the realisation of resveratrol's potential benefits to human health. Over the last 20 years, there have been almost 200 studies evaluating resveratrol across at least 24 indications, including cancer, menopause symptoms, diabetes, metabolic syndrome, and cardiovascular disease. There are currently no consensus treatment regimens for any given condition or endpoint, beyond the fact that resveratrol is generally well-tolerated at a dose of up to 1 g/day. Additionally, resveratrol consistently reduces inflammatory markers and improves aspects of a dysregulated metabolism. In conclusion, over the last 20 years, the increasing weight of clinical evidence suggests resveratrol can benefit human health, but more large, high-quality clinical trials are required to transition this intriguing compound from health food shops to the clinic.
C1 [Brown, Karen; Theofanous, Despoina; Britton, Robert G.; Aburido, Grandezza; Sri Undru, Shanthi; Howells, Lynne] Univ Leicester, Leicester Royal Infirm, Leicester Canc Res Ctr, Robert Kilpatrick Clin Sci Bldg, Leicester LE2 7LX, England.
   [Pepper, Coral] Leicester Royal Infirm, Odames Lib, Victoria Bldg, Leicester LE1 5WW, England.
C3 University of Leicester; University of Leicester
RP Brown, K (corresponding author), Univ Leicester, Leicester Royal Infirm, Leicester Canc Res Ctr, Robert Kilpatrick Clin Sci Bldg, Leicester LE2 7LX, England.
EM kb20@le.ac.uk; dt210@leicester.ac.uk; rgb6@le.ac.uk;
   grandezza.aburido@yahoo.co.uk; ssu4@leicester.ac.uk;
   lh28@leicester.ac.uk
OI Pepper, Coral/0000-0003-1149-8150; Brown, Karen/0000-0002-5217-1501
FU Cancer Research UK
FX No Statement Available
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NR 208
TC 44
Z9 44
U1 31
U2 93
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD JAN
PY 2024
VL 25
IS 2
AR 747
DI 10.3390/ijms25020747
PG 54
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA GE4B1
UT WOS:001150965800001
PM 38255828
OA gold, Green Published
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Rodriguez-Ortiz, CJ
   Thorwald, MA
   Rodriguez, R
   Mejias-Ortega, M
   Kieu, Z
   Maitra, N
   Hawkins, C
   Valenzuela, J
   Peng, M
   Nishiyama, A
   Ortiz, RM
   Kitazawa, M
AF Rodriguez-Ortiz, Carlos J.
   Thorwald, Max A.
   Rodriguez, Ruben
   Mejias-Ortega, Marina
   Kieu, Zanett
   Maitra, Neilabjo
   Hawkins, Charlesice
   Valenzuela, Joanna
   Peng, Marcus
   Nishiyama, Akira
   Ortiz, Rudy M.
   Kitazawa, Masashi
TI Angiotensin receptor blockade with olmesartan alleviates brain pathology
   in obese OLETF rats
SO CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
LA English
DT Article
DE blood-brain barrier; cerebrovasculature; gliosis; hippocampus;
   neurodegeneration; synapse
ID POSTSYNAPTIC DENSITY PROTEINS; OXIDATIVE STRESS; COGNITIVE IMPAIRMENT;
   BARRIER PERMEABILITY; GLUCOSE-INTOLERANCE; HIPPOCAMPUS; ACTIVATION;
   MODEL; INFLAMMATION; MECHANISMS
AB Metabolic syndrome (MetS) is a rapidly increasing health concern during midlife and is an emerging risk factor for the development of neurodegenerative diseases, such as Alzheimer's disease (AD). While angiotensin receptor blockers (ARB) are widely used for MetS-associated hypertension and kidney disease, its therapeutic potential in the brain during MetS are not well-described. Here, we tested whether treatment with ARB could alleviate the brain pathology and inflammation associated with MetS using the Otsuka Long-Evans Tokushima Fatty (OLETF) rat. Here, we report that chronic ARB treatment with olmesartan (10 mg/kg/day by oral gavage for 6 weeks) partially but significantly ameliorated accumulation of oxidized and ubiquitinated proteins, astrogliosis and transformation to neurotoxic astrocytes in the brain of old OLETF rats, which otherwise exhibit the progression of these pathological hallmarks associated with MetS. Additionally, olmesartan treatment restored claudin-5 and ZO-1, markers of the structural integrity of the blood-brain barrier as well as synaptic protein PSD-95, which were otherwise decreased in old OLETF rats, particularly in the hippocampus, a critical region in cognition, memory and AD. These data demonstrate that the progression of MetS in OLETF rats is associated with deterioration of various aspects of neuronal integrity that may manifest neurodegenerative conditions and that overactivation of angiotensin receptor directly or indirectly contributes to these detriments. Thus, olmesartan treatment may slow or delay the onset of degenerative process in the brain and subsequent neurological disorders associated with MetS.
C1 [Rodriguez-Ortiz, Carlos J.; Mejias-Ortega, Marina; Maitra, Neilabjo; Peng, Marcus; Kitazawa, Masashi] Univ Calif Irvine, Ctr Occupat & Environm Hlth, Dept Environm & Occupat Hlth, Dept Med, Irvine, CA USA.
   [Thorwald, Max A.; Rodriguez, Ruben; Kieu, Zanett; Hawkins, Charlesice; Valenzuela, Joanna; Ortiz, Rudy M.] Univ Calif Merced, Dept Mol & Cell Biol, Merced, CA USA.
   [Mejias-Ortega, Marina] Univ Malaga, Fac Ciencias, Dept Cell Biol Genet & Physiol, Inst Invest Biomed Malaga IBIMA, Malaga, Spain.
   [Mejias-Ortega, Marina] Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain.
   [Nishiyama, Akira] Kagawa Med Univ, Dept Pharmacol, Takamatsu, Kagawa, Japan.
   [Kitazawa, Masashi] Univ Calif Irvine, Ctr Occupat & Environm Hlth, Dept Environm andOccupat Hlth, Dept Med, Irvine 92617, CA USA.
   [Ortiz, Rudy M.] Univ Calif Merced, Sch Nat Sci, Dept Mol & Cell Biol, Merced 95343, CA USA.
C3 University of California System; University of California Irvine;
   University of California System; University of California Merced;
   Universidad de Malaga; Instituto de Investigacion Biomedica de Malaga y
   Plataforma en Nanomedicina (IBIMA); CIBERNED; Kagawa University;
   University of California System; University of California Irvine;
   University of California System; University of California Merced
RP Kitazawa, M (corresponding author), Univ Calif Irvine, Ctr Occupat & Environm Hlth, Dept Environm andOccupat Hlth, Dept Med, Irvine 92617, CA USA.; Ortiz, RM (corresponding author), Univ Calif Merced, Sch Nat Sci, Dept Mol & Cell Biol, Merced 95343, CA USA.
EM rortiz@ucmerced.edu; kitazawa@uci.edu
OI Rodriguez, Ruben/0009-0006-5222-7145; Mejias Ortega,
   Marina/0000-0001-7781-9426; Rodriguez, Ruben/0000-0001-8174-2556
FU AstraZeneca; National Institutes of Health; National Heart, Lung, and
   Blood Institute; NIH; National Institute on Minority Health and Health
   Disparities;  [R01-ES024331];  [R01-HL091767];  [T37-MD001480];
   Grants-in-Aid for Scientific Research [22K19712] Funding Source: KAKEN
FX AstraZeneca; National Institutes of Health; National Heart, Lung, and
   Blood Institute; NIH; National Institute on Minority Health and Health
   Disparities
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NR 60
TC 4
Z9 4
U1 1
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0305-1870
EI 1440-1681
J9 CLIN EXP PHARMACOL P
JI Clin. Exp. Pharmacol. Physiol.
PD MAR
PY 2023
VL 50
IS 3
BP 228
EP 237
DI 10.1111/1440-1681.13738
EA DEC 2022
PG 10
WC Pharmacology & Pharmacy; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Physiology
GA 8C8XW
UT WOS:000897695900001
PM 36398458
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Chrysavgis, L
   Giannakodimos, I
   Diamantopoulou, P
   Cholongitas, E
AF Chrysavgis, Lampros
   Giannakodimos, Ilias
   Diamantopoulou, Panagiota
   Cholongitas, Evangelos
TI Non-alcoholic fatty liver disease and hepatocellular carcinoma: Clinical
   challenges of an intriguing link
SO WORLD JOURNAL OF GASTROENTEROLOGY
LA English
DT Review
DE Non-alcoholic fatty liver disease; Hepatocellular carcinoma;
   Epidemiology; Risk factors; Surveillance; Risk stratification
ID ENDOPLASMIC-RETICULUM STRESS; C VIRUS PATIENTS; DIABETES-MELLITUS;
   UNITED-STATES; ALCOHOL-CONSUMPTION; METABOLIC SYNDROME; HEDGEHOG
   PATHWAY; OLMSTED COUNTY; RISK-FACTORS; PHASE-III
AB Non-alcoholic fatty liver disease (NAFLD) has emerged as the most common liver disorder worldwide mainly attributed to the epidemic spread of obesity and type 2 diabetes mellitus. Although it is considered a benign disease, NAFLD can progress to non-alcoholic steatohepatitis, liver cirrhosis and hepatocellular carcinoma (HCC). Most data regarding the epidemiology of NAFLD-related HCC are derived from cohort and population studies and show that its incidence is increasing as well as it is likely to emerge as the leading indication for liver transplantation, especially in the Western World. Although cirrhosis constitutes the main risk factor for HCC development, in patients with NAFLD, HCC can arise in the absence of cirrhosis, indicating specific carcinogenic molecular pathways. Since NAFLD as an underlying liver disease for HCC is often underdiagnosed due to lack of sufficient surveillance in this population, NAFLD-HCC patients are at advanced HCC stage at the time of diagnosis making the management of those patients clinically challenging and affecting their prognostic outcomes. In this current review, we summarize the latest literature on the epidemiology, other than liver cirrhosis-pathogenesis, risk factors and prognosis of NAFLD-HCC patients. Finally, we emphasize the prevention of the development of NAFLD-associated HCC and we provide some insight into the open questions and issues regarding the appropriate surveillance policies for those patients.
C1 [Chrysavgis, Lampros] Natl & Kapodistrian Univ Athens, Dept Expt Physiol, Athens 11527, Greece.
   [Chrysavgis, Lampros; Giannakodimos, Ilias; Diamantopoulou, Panagiota; Cholongitas, Evangelos] Natl & Kapodistrian Univ Athens, Laiko Gen Hosp Athens, Dept Internal Med 1, Agiou Thoma 17, Athens 11527, Greece.
C3 National & Kapodistrian University of Athens; Laiko General Hospital;
   National & Kapodistrian University of Athens
RP Cholongitas, E (corresponding author), Natl & Kapodistrian Univ Athens, Laiko Gen Hosp Athens, Dept Internal Med 1, Agiou Thoma 17, Athens 11527, Greece.
EM cholongitas@yahoo.gr
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NR 135
TC 48
Z9 48
U1 1
U2 19
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 7041 Koll Center Parkway, Suite 160, PLEASANTON, CA, UNITED STATES
SN 1007-9327
EI 2219-2840
J9 WORLD J GASTROENTERO
JI World J. Gastroenterol.
PD JAN 21
PY 2022
VL 28
IS 3
BP 310
EP 331
DI 10.3748/wjg.v28.i3.310
PG 22
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA YP2CQ
UT WOS:000748434400003
PM 35110952
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Ye, C
   Huang, XJ
   Wang, RY
   Halimulati, M
   Aihemaitijiang, S
   Zhang, ZF
AF Ye, Chen
   Huang, Xiaojie
   Wang, Ruoyu
   Halimulati, Mairepaiti
   Aihemaitijiang, Sumiya
   Zhang, Zhaofeng
TI Dietary Inflammatory Index and the Risk of Hyperuricemia: A
   Cross-Sectional Study in Chinese Adult Residents
SO NUTRIENTS
LA English
DT Article
DE dietary inflammatory index; hyperuricemia; diet; risks
ID SERUM URIC-ACID; C-REACTIVE PROTEIN; METABOLIC SYNDROME; OXIDATIVE
   STRESS; VITAMIN-C; BIOMARKERS; DISEASE; HEALTH; GOUT
AB Background: Dietary Inflammatory Index (DII) scores have been consistently associated with several chronic diseases. This study explored the correlation between the DII and hyperuricemia in Chinese adult residents. Methods: The study included 7880 participants from the China Health and Nutrition Survey (CHNS), which was taken in in 2009. A 3-day 24 h meal review method was used to collect diet data and to calculate the DII score. Serum uric acid was obtained to determine hyperuricemia levels. Subjects were divided into a hyperuricemia group and a non-hyperuricemia group, according to their serum uric acid level. Multilevel logistic regression models were used to examine the association between DII scores and hyperuricemia. Results: After adjusting for covariates, a higher DII score was determined to be associated with a higher risk of hyperuricemia. Compared to those in the highest DII score group, the lower DII score group had an inverse association with hyperuricemia risk (Q2: 0.83, 95% CI: 0.70-0.99; Q3: 0.72, 95% CI: 0.60-0.86; Q4: 0.73, 95% CI: 0.61-0.88). The intake of energy-adjusted protein, total fat, MUFAs, PUFAs and saturated fatty acid was higher in the hyperuricemia group. Conclusions: A higher DII score is significantly associated with a higher risk of hyperuricemia. Controlling the intake of pro-inflammatory food may be beneficial to reduce the risk of hyperuricemia.
C1 [Ye, Chen; Huang, Xiaojie; Wang, Ruoyu; Halimulati, Mairepaiti; Aihemaitijiang, Sumiya; Zhang, Zhaofeng] Peking Univ, Sch Publ Hlth, Hlth Sci Ctr, Dept Nutr & Food Hyg, Beijing 100191, Peoples R China.
C3 Peking University
RP Zhang, ZF (corresponding author), Peking Univ, Sch Publ Hlth, Hlth Sci Ctr, Dept Nutr & Food Hyg, Beijing 100191, Peoples R China.
EM 10306235@pku.edu.cn; 13161518166@163.com; 1710108607@bjmu.edu.cn;
   2011210145@bjmu.edu.cn; 1410606101@pku.edu.cn; zhangzhaofeng@bjmu.edu.cn
RI Huang, Xiaojie/U-6572-2018
OI Zhang, Zhaofeng/0000-0002-9751-1549
FU NIH [R01-HD30880, DK056350, R01-HD38700]; Fogarty International Center;
   China-Japan Friendship Hospital, Ministry of Health
FX This research uses data from China Health and Nutrition Survey (CHNS).
   We thank the National Institute of Nutrition and Food Safety, China
   Center for Disease Control and Prevention, Carolina Population Center,
   the University of North Carolina at Chapel Hill, the NIH(R01-HD30880,
   DK056350, and R01-HD38700) and the Fogarty International Center, NIH for
   financialsupport for the CHNS data collection and analysis files from
   1989 to 2006 and both parties plus the China-Japan Friendship Hospital,
   Ministry of Health for support for CHNS 2009 and future surveys.
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PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
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J9 NUTRIENTS
JI Nutrients
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IS 12
AR 4504
DI 10.3390/nu13124504
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA XY5AG
UT WOS:000736984500001
PM 34960057
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Di Bonaventura, MVM
   Coman, MM
   Tomassoni, D
   Di Bonaventura, EM
   Botticelli, L
   Gabrielli, MG
   Rossolini, GM
   Di Pilato, V
   Cecchini, C
   Amedei, A
   Silvi, S
   Verdenelli, MC
   Cifani, C
AF Di Bonaventura, Maria Vittoria Micioni
   Coman, Maria Magdalena
   Tomassoni, Daniele
   Di Bonaventura, Emanuela Micioni
   Botticelli, Luca
   Gabrielli, Maria Gabriella
   Rossolini, Gian Maria
   Di Pilato, Vincenzo
   Cecchini, Cinzia
   Amedei, Amedeo
   Silvi, Stefania
   Verdenelli, Maria Cristina
   Cifani, Carlo
TI Supplementation with Lactiplantibacillus plantarum IMC 510
   Modifies Microbiota Composition and Prevents Body Weight Gain Induced by
   Cafeteria Diet in Rats
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE microbiota; 16S; obesity; cafeteria (CAF) diet; Lactiplantibacillus (L.)
   plantarum IMC 510; leptin; body weight; food intake
ID HIGH-FAT DIET; INDUCED OBESITY; GUT MICROBIOTA; WESTERN DIET;
   LACTOBACILLUS-ACIDOPHILUS; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   OXIDATIVE STRESS; ENERGY-BALANCE; LEPTIN
AB Changes in functionality and composition of gut microbiota (GM) have been associated and may contribute to the development and maintenance of obesity and related diseases. The aim of our study was to investigate for the first time the impact of Lactiplantibacillus (L.) plantarum IMC 510 in a rat model of diet-induced obesity, specifically in the cafeteria (CAF) diet. This diet provides a strong motivation to voluntary overeat, due to the palatability and variety of selected energy-dense foods. The oral administration for 84 days of this probiotic strain, added to the CAF diet, decreased food intake and body weight gain. Accordingly, it ameliorated body mass index, liver and white adipose tissue weight, hepatic lipid accumulation, adipocyte size, serum parameters, including glycemia and low-density lipoprotein levels, in CAF fed rats, potentially through leptin control. In this scenario, L. plantarum IMC 510 showed also beneficial effects on GM, limiting the microbial imbalance established by long exposure to CAF diet and preserving the proportion of different bacterial taxa. Further research is necessary to better elucidate the relationship between GM and overweight and then the mechanism of action by which L. plantarum IMC 510 modifies weight. However, these promising results prompt a clear advantage of probiotic supplementation and identify a new potential probiotic as a novel and safe therapeutic approach in obesity prevention and management.
C1 [Di Bonaventura, Maria Vittoria Micioni; Di Bonaventura, Emanuela Micioni; Botticelli, Luca; Cifani, Carlo] Univ Camerino, Sch Pharm, Pharmacol Unit, I-62032 Camerino, Italy.
   [Coman, Maria Magdalena; Cecchini, Cinzia; Verdenelli, Maria Cristina] Synbiotec Srl, Spin Off UNICAM, Via Gentile III Da Varano, I-62032 Camerino, Italy.
   [Tomassoni, Daniele; Gabrielli, Maria Gabriella; Silvi, Stefania] Univ Camerino, Sch Biosci & Vet Med, I-62032 Camerino, Italy.
   [Rossolini, Gian Maria; Amedei, Amedeo] Univ Florence, Dept Expt & Clin Med, I-50134 Florence, Italy.
   [Rossolini, Gian Maria] Florence Careggi Univ Hosp, Microbiol & Virol Unit, I-50134 Florence, Italy.
   [Di Pilato, Vincenzo] Univ Genoa, Dept Surg Sci & Integrated Diagnost, I-16132 Genoa, Italy.
C3 University of Camerino; University of Camerino; University of Camerino;
   University of Florence; University of Florence; Azienda Ospedaliero
   Universitaria Careggi; University of Genoa
RP Silvi, S (corresponding author), Univ Camerino, Sch Biosci & Vet Med, I-62032 Camerino, Italy.
EM mariavittoria.micioni@unicam.it; magda.coman@unicam.it;
   daniele.tomassoni@unicam.it; emanuela.micioni@unicam.it;
   luca.botticelli@unicam.it; gabriella.gabrielli@unicam.it;
   gianmaria.rossolini@unifi.it; vincenzo.dipilato@unige.it;
   cinzia.cecchini@unicam.it; amedeo.amedei@unifi.it;
   stefania.silvi@unicam.it; cristina.verdenelli@unicam.it;
   carlo.cifani@unicam.it
RI Micioni Di Bonaventura, Maria Vittoria/AAC-5447-2022; Cifani,
   Carlo/AAC-5456-2022; Amedei, Amedeo/G-5378-2011; ROSSOLINI,
   Gian/K-2112-2018; Di Pilato, Vincenzo/K-1182-2018
OI Di Pilato, Vincenzo/0000-0002-5863-5805; Micioni Di Bonaventura, Maria
   Vittoria/0000-0002-8044-1206; Botticelli, Luca/0000-0002-5414-2368;
   Cifani, Carlo/0000-0001-6180-828X; Silvi, Stefania/0000-0002-4755-6239;
   Micioni Di Bonaventura, Emanuela/0000-0001-8484-7513; Tomassoni,
   Daniele/0000-0001-9062-3305
FU Italian Ministry of Education, University and Research [2012JTX3KL]
FX This work was supported by the Italian Ministry of Education, University
   and Research grant (PRIN2012 prot. #2012JTX3KL) to CC.
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NR 117
TC 16
Z9 16
U1 1
U2 11
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD OCT
PY 2021
VL 22
IS 20
AR 11171
DI 10.3390/ijms222011171
PG 24
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA WT9BK
UT WOS:000716152200001
PM 34681831
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Cheng, HY
   Chair, SY
   Wang, Q
   Cao, X
   Cheng, L
   Lee, IFK
AF Cheng, Ho Yu
   Chair, Sek Ying
   Wang, Qun
   Cao, Xi
   Cheng, Li
   Lee, Iris F. K.
TI Measuring exercise self-efficacy in Hong Kong Chinese adults with
   cardiovascular risk: Validation of a Chinese version of the Cardiac
   Exercise Self-efficacy Instrument
SO RESEARCH IN NURSING & HEALTH
LA English
DT Article
DE cardiac exercise self-efficacy instrument; cardiovascular risks;
   exercise capacity; instrument validation
ID PHYSICAL-ACTIVITY; METABOLIC SYNDROME; INTERVENTION; BARRIERS; BELIEFS;
   SUPPORT
AB About one-third of adults are physically inactive and thus prone to cardiovascular diseases. While self-efficacy mediates health behavior, its influences on exercise behavior among Chinese is yet to be explored by a validated instrument. This study aimed to examine the psychometric properties of the Hong Kong Chinese version of the Cardiac Exercise Self-efficacy Instrument (CESEI-C), which had been translated previously by these authors. The psychometric properties of the CESEI-C were tested with 160 Hong Kong Chinese with cardiovascular risk. Participants were asked to complete the CESEI-C, a physical activity assessment tool, and perform the exercise stress test. Exploratory factor analysis identified a unidimensional structure of the CESEI-C. Good internal consistency (Cronbach's alpha = 0.91) and good content validity (content validity indices: 0.93-1.00) had been reported previously. The convergent validity of the CESEI-C was supported by the significant positive correlations between the CESEI-C score and the amount of moderate-to-vigorous exercise (r = 0.18, p = 0.03), and exercise capacity (r = 0.30, p < 0.01). A comparison of CESEI-C scores by exercise capacities indicated that those with moderate-to-high exercise capacity had significantly higher CESEI scores than those with low exercise capacity (t = 2.105, p = 0.04). Thus, the CESEI-C is a valid and reliable instrument to measure exercise self-efficacy among Hong Kong Chinese.
C1 [Cheng, Ho Yu; Chair, Sek Ying; Cao, Xi; Cheng, Li; Lee, Iris F. K.] Chinese Univ Hong Kong, Nethersole Sch Nursing, Fac Med, Shatin, Hong Kong, Peoples R China.
   [Wang, Qun] Shenzhen Univ, Sch Nursing, Shenzhen, Peoples R China.
C3 Chinese University of Hong Kong; Shenzhen University
RP Chair, SY (corresponding author), Chinese Univ Hong Kong, Nethersole Sch Nursing, Fac Med, Shatin, Hong Kong, Peoples R China.
EM sychair@cuhk.edu.hk
RI WANG, Qun/AAP-9908-2021; Cheng, Ho/L-9917-2016; Lee, Iris/O-3864-2015;
   Cheng, Liang/B-4557-2013; Chair, Sek/IVV-5916-2023; Chair, Sek
   Ying/G-9965-2016
OI Chair, Sek Ying/0000-0003-2387-7035; Cheng, Ho Yu/0000-0002-5842-9390;
   Wang, Qun/0000-0001-7594-8312
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NR 34
TC 8
Z9 9
U1 0
U2 24
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0160-6891
EI 1098-240X
J9 RES NURS HEALTH
JI Res. Nurs. Health
PD APR
PY 2019
VL 42
IS 2
BP 148
EP 154
DI 10.1002/nur.21936
PG 7
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA HP0TB
UT WOS:000461378000007
PM 30710372
DA 2025-06-11
ER

PT J
AU Boutagy, NE
   McMillan, RP
   Frisard, MI
   Hulver, MW
AF Boutagy, Nabil E.
   McMillan, Ryan P.
   Frisard, Madlyn I.
   Hulver, Matthew W.
TI Metabolic endotoxemia with obesity: Is it real and is it relevant?
SO BIOCHIMIE
LA English
DT Review
DE Obesity; Metabolic endotoxemia; Substrate metabolism; Inflammation;
   Endotoxin detection
ID LOW-GRADE INFLAMMATION; INDUCED INSULIN-RESISTANCE; HUMAN GUT
   MICROBIOTA; HIGH-FAT DIET; REACTIVE OXYGEN; BINDING PROTEIN;
   ADIPOSE-TISSUE; SEVERE SEPSIS; BLOOD-SUGAR; LIPOPOLYSACCHARIDE
AB Obesity is associated with metabolic derangements in multiple tissues, which contribute to the progression of insulin resistance and the metabolic syndrome. The underlying stimulus for these metabolic derangements in obesity are not fully elucidated, however recent evidence in rodents and humans suggests that systemic, low level elevations of gut derived endotoxin (lipopolysaccharide, LPS) may play an important role in obesity related, whole-body and tissue specific metabolic perturbations. LPS initiates a well-characterized signaling cascade that elicits many pro- and anti-inflammatory pathways when bound to its receptor, Toll-Like Receptor 4 (TLR4). Low-grade elevation in plasma LPS has been termed "metabolic endotoxemia" and this state is associated with a heightened pro-inflammatory and oxidant environment often observed in obesity. Given the role of inflammatory and oxidative stress in the etiology of obesity related cardio-metabolic disease risk, it has been suggested that metabolic endotoxemia may serve a key mediator of metabolic derangements observed in obesity. This review provides supporting evidence of mechanistic associations with cell and animal models, and provides complimentary evidence of the clinical relevance of metabolic endotoxemia in obesity as it relates to inflammation and metabolic derangements in humans. Discrepancies with endotoxin detection are considered, and an alternate method of reporting metabolic endotoxemia is recommended until a standardized measurement protocol is set forth. (C) 2015 Elsevier B.V. and Societe Francaise de Biochimie et Biologie Moleculaire (SFBBM). All rights reserved.
C1 [Boutagy, Nabil E.; McMillan, Ryan P.; Frisard, Madlyn I.; Hulver, Matthew W.] Virginia Tech, Dept Human Nutr Foods & Exercise, 295 West Campus Dr, Blacksburg, VA 24061 USA.
   [Boutagy, Nabil E.; McMillan, Ryan P.; Frisard, Madlyn I.; Hulver, Matthew W.] Virginia Tech, Fralin Translat Obes Res Ctr, 1981 Kraft Dr, Blacksburg, VA 24061 USA.
   [Boutagy, Nabil E.; McMillan, Ryan P.; Frisard, Madlyn I.; Hulver, Matthew W.] Virginia Tech, Metab Phenotyping Core, 1981 Kraft Dr, Blacksburg, VA 24061 USA.
C3 Virginia Polytechnic Institute & State University; Virginia Polytechnic
   Institute & State University; Virginia Polytechnic Institute & State
   University
RP Hulver, MW (corresponding author), Virginia Tech, 295 West Campus Dr,338 Wallace Hall, Blacksburg, VA 24061 USA.
EM nabilb@vt.edu; mcmillr@vt.edu; frisardm@vt.edu; hulvermw@vt.edu
OI Boutagy, Nabil/0000-0003-1994-9075
FU American Diabetes Association [1-JF-05-24, 1-13-CE-16]; National
   Institutes of Health [RO1 DK-078765, R56 DK-078765]; Fralin Life
   Sciences Institute at Virginia Tech
FX This work was funded by grants from the American Diabetes Association
   (1-JF-05-24 and 1-13-CE-16, M. Hulver) and the National Institutes of
   Health (RO1 DK-078765 and R56 DK-078765, M. Hulver) and from funds from
   the Fralin Life Sciences Institute at Virginia Tech.
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NR 104
TC 286
Z9 320
U1 3
U2 132
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0300-9084
EI 1638-6183
J9 BIOCHIMIE
JI Biochimie
PD MAY
PY 2016
VL 124
BP 11
EP 20
DI 10.1016/j.biochi.2015.06.020
PG 10
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA DK4UZ
UT WOS:000374917100003
PM 26133659
OA Green Accepted
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Linna, MS
   Ahotupa, M
   Kukkonen-Harjula, K
   Fogelholm, M
   Vasankari, TJ
AF Linna, Meri S.
   Ahotupa, Markku
   Kukkonen-Harjula, Katriina
   Fogelholm, Mikael
   Vasankari, Tommi J.
TI Co-existence of insulin resistance and high concentrations of
   circulating oxidized LDL lipids
SO ANNALS OF MEDICINE
LA English
DT Article
DE Atherosclerosis; insulin resistance; life-style; oxidized low-density
   lipoprotein; risk factors
ID LINE DIENE CONJUGATION; WEIGHT-LOSS; METABOLIC SYNDROME; OXIDATIVE
   STRESS; PLASMA-GLUCOSE; LIPOPROTEIN; ADULTS; CD36; ATHEROSCLEROSIS;
   INFLAMMATION
AB Introduction. Insulin metabolism has been previously linked to oxidized low-density lipoproteins (ox-LDL), but corroborating intervention studies are lacking. We investigated whether changes in ox-LDL levels are accompanied by changes in insulin sensitivity in a 32-month life-style intervention study.
   Materials and methods. A 2-month weight reduction was followed by 6-month diet and exercise counselling and a 2-year follow-up period. Men of 35 -50 years of age, BMI >= 30 kg/m(2), and waist circumference > 100 cm were recruited via newspapers in the city of Tampere, Finland. Of the 90 men meeting the inclusion criteria, 67 (76%) completed the study. Ox-LDL was estimated as the presence of oxidized lipids in LDL. Homeostasis model assessment of insulin resistance (HOMA-IR), ox-LDL, and ratio of ox-LDL and high-density lipoprotein cholesterol (ox-LDL/HDL-c) were used as the main outcome measures.
   Results. The detected changes in HOMA-IR were strikingly similar to those in ox-LDL and ox-LDL/HDL-c. Compared to the first HOMA-IR quartile, the fourth quartile had 23%-51% higher concentrations in ox-LDL and ox-LDL/HDL-c at all time points (P < 0.05 for all).
   Conclusion. This weight reduction intervention study adds evidence to support the connection between insulin metabolism and oxidized LDL, possibly contributing to the higher incidence of atherosclerotic cardiovascular diseases among diabetic patients.
C1 [Linna, Meri S.] Univ Turku, Dept Phys Act & Hlth, Paavo Nurmi Ctr, Turku, Finland.
   [Ahotupa, Markku] Univ Turku, Dept Physiol, MCA Res Lab, Turku, Finland.
   [Kukkonen-Harjula, Katriina; Vasankari, Tommi J.] UKK Inst Hlth Promot Res, Tampere, Finland.
   [Fogelholm, Mikael] Univ Helsinki, Dept Food & Environm Sci, Helsinki, Finland.
C3 University of Turku; University of Turku; UKK Institute; University of
   Helsinki
RP Linna, MS (corresponding author), Paavo Nurmi Ctr, Dept Phys Act & Hlth, Kiinamyllynkatu 10, FI-20520 Turku, Finland.
EM mlinna@utu.fi
OI Linna, Meri/0000-0001-6168-3261
FU Turku University Foundation; Juho Vainio Foundation; Aarne Koskelo
   Foundation; Finnish Foundation for Cardiovascular Research; Emil and
   Bilda Maunula Foundation
FX This work was supported by Turku University Foundation, Juho Vainio
   Foundation, Aarne Koskelo Foundation, Finnish Foundation for
   Cardiovascular Research and Emil and Bilda Maunula Foundation.
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NR 30
TC 20
Z9 20
U1 0
U2 1
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 0785-3890
EI 1365-2060
J9 ANN MED
JI Ann. Med.
PY 2015
VL 47
IS 5
BP 394
EP 398
DI 10.3109/07853890.2015.1043939
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA CS6FA
UT WOS:000362172000005
PM 26300237
OA Bronze
DA 2025-06-11
ER

PT J
AU Gaudio, E
   Nobili, V
   Franchitto, A
   Onori, P
   Carpino, G
AF Gaudio, Eugenio
   Nobili, Valerio
   Franchitto, Antonio
   Onori, Paolo
   Carpino, Guido
TI Nonalcoholic fatty liver disease and atherosclerosis
SO INTERNAL AND EMERGENCY MEDICINE
LA English
DT Article
DE NAFLD; Atherosclerosis; NASH; Vulnerable plaque; Adipokine
ID GLUCAGON-LIKE PEPTIDE-1; RISK-ASSESSMENT STRATEGIES;
   CARDIOVASCULAR-DISEASE; VULNERABLE PATIENT; MOLECULAR-BASIS;
   ADIPOSE-TISSUE; SHEAR-STRESS; MACROPHAGES; PLAQUE; INFLAMMATION
AB Atherosclerosis is a complex inflammatory disease comprising multiple plaque phenotypes. The development of advanced atheromatous plaques with necrotic core represents the result of the invasion of lipid pools by macrophages. The release of activated proteolytic enzymes degrades the surrounding tissue and contributes to the formation of vulnerable plaque. Thinning of the fibrous cap and necrotic core expansion are considered to be critical for the progression toward plaque rupture and acute thrombosis. The pathogenic mechanisms leading the progression of atherosclerotic lesions are various and involve endothelial cells, inflammatory cells, and platelets. Nonalcoholic fatty liver disease (NAFLD) includes a spectrum of diseases ranging from simple fatty liver to nonalcoholic steatohepatitis (NASH) and may progress to cirrhosis and hepatocellular carcinoma. The prevalence of this pathology is quite high in the general population and is one of the most important causes of liver-related morbidity and mortality in children. NAFLD is considered the hepatic feature of the metabolic syndrome and this has stimulated interest in its possible role in the atherosclerosis development. Clinical observations indicated that NAFLD might be an independent risk factor for coronary artery disease. Moreover, NASH may increase atherosclerotic and cardiovascular risks by local overexpression of inflammatory mediators, endothelial damage, and regulators of blood pressure. NASH development is correlated with hepatic progenitor cell activation and the release of proatherogenic adipokines. These aspects suggest the necessity for an early therapeutic intervention in NASH patients, not only for ameliorating the liver injury, but also for improving the systemic proatherogenic state.
C1 [Gaudio, Eugenio; Franchitto, Antonio] Sapienza Univ Rome, Dept Human Anat Histol Forens Med & Orthoped, Via Borelli 50, I-00161 Rome, Italy.
   [Nobili, Valerio] Bambino Gesu Pediat Hosp, Unit Liver Res, IRCCS, Rome, Italy.
   [Franchitto, Antonio] Eleonora Lorillard Spencer Cenci Fdn, Rome, Italy.
   [Onori, Paolo] Univ Aquila, Dept Expt Med, Laquila, Italy.
   [Carpino, Guido] Univ Rome Foro Italico, Dept Hlth Sci, Rome, Italy.
C3 Sapienza University Rome; IRCCS Bambino Gesu; University of L'Aquila;
   Foro Italico University of Rome
RP Gaudio, E (corresponding author), Sapienza Univ Rome, Dept Human Anat Histol Forens Med & Orthoped, Via Borelli 50, I-00161 Rome, Italy.
EM eugenio.gaudio@uniroma1.it
RI Carpino, Guido/AAB-9692-2019; Nobili, Valerio/K-8670-2018; Franchitto,
   Antonio/C-8095-2009; Onori, Paolo/J-9394-2013
OI Onori, Paolo/0000-0002-7195-3760; nobili, valerio/0000-0002-4570-3979;
   CARPINO, Guido/0000-0001-8570-2519; FRANCHITTO,
   Antonio/0000-0003-0822-3690
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TC 44
Z9 47
U1 1
U2 7
PU SPRINGER-VERLAG ITALIA SRL
PI MILAN
PA VIA DECEMBRIO, 28, MILAN, 20137, ITALY
SN 1828-0447
EI 1970-9366
J9 INTERN EMERG MED
JI Intern. Emerg. Med.
PD OCT
PY 2012
VL 7
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BP S297
EP S305
DI 10.1007/s11739-012-0826-5
PG 9
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA V45UX
UT WOS:000209842600019
PM 23073871
DA 2025-06-11
ER

PT J
AU Fond, G
   Godin, O
   Boyer, L
   Berna, F
   Andrianarisoa, M
   Coulon, N
   Brunel, L
   Bulzacka, E
   Aouizerate, B
   Capdevielle, D
   Chereau, I
   D'Amato, T
   Dubertret, C
   Dubreucq, J
   Faget, C
   Leignier, S
   Lancon, C
   Mallet, J
   Misdrahi, D
   Passerieux, C
   Rey, R
   Schandrin, A
   Urbach, M
   Vidailhet, P
   Llorca, PM
   Schuerhoff, F
   Leboyer, M
   Andrianarisoa, M
   Aouizerate, B
   Berna, F
   Blanc, O
   Brunel, L
   Bulzacka, E
   Capdevielle, D
   Chereau-Boudet, I
   Chesnoy-Servanin, G
   Danion, JM
   D'Amato, T
   Deloge, A
   Delorme, C
   Denizot, H
   Dorey, JM
   Dubertret, C
   Dubreucq, J
   Faget, C
   Fluttaz, C
   Fond, G
   Fonteneau, S
   Gabayet, F
   Giraud-Baro, E
   Hardy-Bayle, MC
   Lacelle, D
   Lancon, C
   Laouamri, H
   Leboyer, M
   Le Gloahec, T
   Le Strat, Y
   Llorca, PM
   Mallet, J
   Metairie, E
   Misdrahi, D
   Offerlin-Meyer, I
   Passerieux, C
   Peri, P
   Pires, S
   Portalier, C
   Ramet, L
   Rey, R
   Roman, C
   Sebilleau, M
   Schandrin, A
   Schurhoff, F
   Tessier, A
   Tronche, AM
   Urbach, M
   Vaillant, F
   Vehier, A
   Vidailhet, P
   Vila, E
   Yazbek, H
   Zinetti-Bertschy, A
AF Fond, G.
   Godin, O.
   Boyer, L.
   Berna, F.
   Andrianarisoa, M.
   Coulon, N.
   Brunel, L.
   Bulzacka, E.
   Aouizerate, B.
   Capdevielle, D.
   Chereau, I.
   D'Amato, T.
   Dubertret, C.
   Dubreucq, J.
   Faget, C.
   Leignier, S.
   Lancon, C.
   Mallet, J.
   Misdrahi, D.
   Passerieux, C.
   Rey, R.
   Schandrin, A.
   Urbach, M.
   Vidailhet, P.
   Llorca, P. M.
   Schuerhoff, F.
   Leboyer, M.
   Andrianarisoa, M.
   Aouizerate, B.
   Berna, F.
   Blanc, O.
   Brunel, L.
   Bulzacka, E.
   Capdevielle, D.
   Chereau-Boudet, I.
   Chesnoy-Servanin, G.
   Danion, J. M.
   D'Amato, T.
   Deloge, A.
   Delorme, C.
   Denizot, H.
   Dorey, J. M.
   Dubertret, C.
   Dubreucq, J.
   Faget, C.
   Fluttaz, C.
   Fond, G.
   Fonteneau, S.
   Gabayet, F.
   Giraud-Baro, E.
   Hardy-Bayle, M. C.
   Lacelle, D.
   Lancon, C.
   Laouamri, H.
   Leboyer, M.
   Le Gloahec, T.
   Le Strat, Y.
   Llorca, P. M.
   Mallet, J.
   Metairie, E.
   Misdrahi, D.
   Offerlin-Meyer, I.
   Passerieux, C.
   Peri, P.
   Pires, S.
   Portalier, C.
   Ramet, L.
   Rey, R.
   Roman, C.
   Sebilleau, M.
   Schandrin, A.
   Schurhoff, F.
   Tessier, A.
   Tronche, A. M.
   Urbach, M.
   Vaillant, F.
   Vehier, A.
   Vidailhet, P.
   Vila, E.
   Yazbek, H.
   Zinetti-Bertschy, A.
CA FACE-SZ FondaMental Acad Ctr
TI Chronic low-grade peripheral inflammation is associated with ultra
   resistant schizophrenia. Results from the FACE-SZ cohort
SO EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
LA English
DT Article
DE Resistant schizophrenia; Inflammation; Functioning
ID POOR TREATMENT RESPONSE; ANTIINFLAMMATORY DRUGS; BIOLOGICAL PSYCHIATRY;
   1ST EPISODE; GUIDELINES; CLOZAPINE; DEPRESSION; MANAGEMENT; DISORDERS;
   CONSENSUS
AB A high rate of patients with schizophrenia (SZ) does not sufficiently respond to antipsychotic medication, which is associated with relapses and poor outcomes. Chronic peripheral inflammation has been repeatedly associated with schizophrenia risk and particularly to poor responders to treatment as usual with cognitive impairment in SZ subjects. The objective of present study was to confirm if ultra resistance to treatment in schizophrenia (UTRS) was associated to chronic peripheral inflammation in a non-selected sample of community-dwelling outpatients with schizophrenia. Participants were consecutively included in the network of the FondaMental Expert Centers for Schizophrenia and received a thorough clinical assessment, including recording of current treatment. Current psychotic symptomatology was evaluated by the Positive and Negative Syndrome scale for Schizophrenia (PANSS). UTRS was defined by current clozapine treatment + PANSS total score >= 70. Functioning was evaluated by the Global Assessment of Functioning scale. High sensitivity CRP (hs-CRP) was measured for each participant as a proxy to define peripheral low-grade inflammation. 609 stabilized community-dwelling SZ subjects (mean age = 32.5 years, 73.6% male gender) have been included. 60 (9.9%) patients were classified in the UTRS group. In multivariate analyses, UTRS has been associated independently with chronic peripheral inflammation (OR = 2.6 [1.2-5.7], p = 0.01), illness duration (0R = 1.1 [1.0-1.2], p = 0.02) and impaired functioning (OR = 0.9 [0.9-0.9], p = 0.0002) after adjustment for age, sex, current daily tobacco smoking, metabolic syndrome and antidepressant consumption. Peripheral low-grade inflammation is associated with UTRS. Future studies should explore if anti-inflammatory strategies are effective in UTRS with chronic low-grade peripheral inflammation.
C1 [Fond, G.; Godin, O.; Boyer, L.; Berna, F.; Andrianarisoa, M.; Coulon, N.; Brunel, L.; Bulzacka, E.; Aouizerate, B.; Capdevielle, D.; Chereau, I.; D'Amato, T.; Dubertret, C.; Dubreucq, J.; Faget, C.; Leignier, S.; Lancon, C.; Mallet, J.; Misdrahi, D.; Passerieux, C.; Rey, R.; Schandrin, A.; Urbach, M.; Llorca, P. M.; Schuerhoff, F.; Leboyer, M.] Fdn FondaMental, Creteil, France.
   [Godin, O.; Andrianarisoa, M.; Coulon, N.; Brunel, L.; Bulzacka, E.; Schuerhoff, F.; Leboyer, M.] INSERM, U955, Equipe Psychiat Translat, Creteil, France.
   [Godin, O.; Andrianarisoa, M.; Coulon, N.; Brunel, L.; Bulzacka, E.; Schuerhoff, F.; Leboyer, M.] Univ Paris Est Creteil, DHU Pe PSY, Pole Psychiat Hop Univ H Mondor, Creteil, France.
   [Fond, G.; Boyer, L.] Aix Marseille Univ, Fac Med, Sect Timone, EA 3279 CEReSS Ctr Etud & Rech Serv Sante & Quali, 27 Blvd Jean Moulin, F-13005 Marseille, France.
   [Aouizerate, B.; Misdrahi, D.] Univ Bordeaux, Ctr Hosp Charles Perrens, F-33076 Bordeaux, France.
   [Berna, F.; Vidailhet, P.] Univ Strasbourg, Hop Univ Strasbourg, INSERM, U1114,Federat Med Translat Strasbourg, Strasbourg, France.
   [Capdevielle, D.; Schandrin, A.] Univ Montpellier I, CHRU Montpellier, Hop Colombiere, Serv Univ Psychiat Adulte,Inserm 1061, Montpellier, France.
   [Chereau, I.; Llorca, P. M.] Univ Auvergne, Fac Med, CMP B, CHU,EA 7280, BP 69, F-63003 Clermont Ferrand 1, France.
   [D'Amato, T.; Rey, R.] Univ Claude Bernard Lyon 1, INSERM, U1028,Ctr Hosp Le Vinatier, CNRS,UMR5292,Ctr Rech Neurosci Lyon,Equipe PSYR2, 95 Bd Pinel,BP 30039, F-69678 Bron, France.
   [Dubertret, C.; Mallet, J.] Univ Paris Diderot, Fac Med, Sorbonne Paris Cite,Colombes, Louis Mourier Hosp,AP HP,Dept Psychiat,Inserm,U89, Paris, France.
   [Dubreucq, J.; Leignier, S.] CH Alpes Isere, Ctr Referent Rehabil Psychosociale, Grenoble, France.
   [Faget, C.; Lancon, C.] AP HM, Pole Univ Psychiat, Marseille, France.
   [Passerieux, C.; Urbach, M.] Univ Versailles St Quentin Yvelines, UFR Sci Sante Simone Veil, Serv Psychiat Adulte, Ctr Hosp Versailles, Versailles, France.
   [Aouizerate, B.] Univ Bordeaux, INRA, NutriNeuro, U1286, F-33076 Bordeaux, France.
   [Misdrahi, D.] Univ Bordeaux, CNRS, UMR 5287, INCIA, Bordeaux, France.
C3 Institut National de la Sante et de la Recherche Medicale (Inserm);
   Universite Paris-Est-Creteil-Val-de-Marne (UPEC); Assistance Publique
   Hopitaux Paris (APHP); Universite Paris-Est-Creteil-Val-de-Marne (UPEC);
   Hopital Universitaire Henri-Mondor - APHP; Aix-Marseille Universite;
   Universite de Bordeaux; Universite de Lorraine; CHU Strasbourg; Institut
   National de la Sante et de la Recherche Medicale (Inserm); Universites
   de Strasbourg Etablissements Associes; Universite de Strasbourg;
   Institut National de la Sante et de la Recherche Medicale (Inserm);
   Universite de Montpellier; CHU de Montpellier; Universite Clermont
   Auvergne (UCA); CHU Clermont Ferrand; Centre National de la Recherche
   Scientifique (CNRS); Institut National de la Sante et de la Recherche
   Medicale (Inserm); Universite Claude Bernard Lyon 1; Universite Jean
   Monnet; CNRS - National Institute for Biology (INSB); Institut National
   de la Sante et de la Recherche Medicale (Inserm); Universite Paris Cite;
   Assistance Publique Hopitaux Paris (APHP); Hopital Universitaire
   Louis-Mourier - APHP; Aix-Marseille Universite; Assistance
   Publique-Hopitaux de Marseille; Universite Paris Saclay; Centre
   Hospitalier de Versailles; Universite de Bordeaux; INRAE; Institut
   National de la Sante et de la Recherche Medicale (Inserm); Centre
   National de la Recherche Scientifique (CNRS); Universite de Bordeaux;
   CNRS - National Institute for Biology (INSB)
RP Fond, G (corresponding author), Fdn FondaMental, Creteil, France.; Fond, G (corresponding author), Aix Marseille Univ, Fac Med, Sect Timone, EA 3279 CEReSS Ctr Etud & Rech Serv Sante & Quali, 27 Blvd Jean Moulin, F-13005 Marseille, France.
EM guillaume.fond@ap-hm.fr
RI Fond, Guillaume/D-7646-2011; Mallet, Jasmina/GNP-7160-2022; Leboyer,
   Marion/AAW-3648-2021; Schandrin, Aurélie/ISV-4608-2023; COULON,
   Nathalie/HLW-3075-2023; Boyer, Laurent/E-5728-2016; Capdevielle,
   Delphine/HTO-4229-2023; JeanMichel, Dorey/KHZ-0906-2024; Le Strat,
   Yann/C-9848-2013; Berna, Fabrice/J-2701-2019; TESSIER,
   Arnaud/A-4022-2017
OI D'Amato, Thierry/0000-0001-8983-0315; Capdevielle,
   Delphine/0000-0002-7146-8554; Aouizerate, Bruno/0000-0002-7092-7747;
   TESSIER, Arnaud/0000-0001-5758-5693; COULON,
   Nathalie/0000-0001-7765-1117; Misdrahi, David/0000-0003-1146-3206;
   LEBOYER, Marion/0000-0001-5473-3697; REY, Romain/0000-0002-4603-3575;
   dubreucq, julien/0000-0003-4079-4194
FU AP-HM (Assistance Publique des Hopitaux de Marseille); Fondation
   FondaMental (RTRS Sante Mentale); Investissements d'Avenir program
   [ANR-11-IDEX-0004-02, ANR-10-COHO-10-01]
FX This work was funded by AP-HM (Assistance Publique des Hopitaux de
   Marseille), Fondation FondaMental (RTRS Sante Mentale), by the
   Investissements d'Avenir program managed by the ANR under reference
   ANR-11-IDEX-0004-02 and ANR-10-COHO-10-01. We express all our thanks to
   the nurses, and to the patients who were included in the present study.
   We thank Hakim Laouamri, and his team (Stephane Beaufort, Seif Ben
   Salem, Karmene Souyris, Victor Barteau and Mohamed Laaidi) for the
   development of the FACE-SZ computer interface, data management, quality
   control and regulatory aspects.
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NR 49
TC 52
Z9 53
U1 0
U2 16
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0940-1334
EI 1433-8491
J9 EUR ARCH PSY CLIN N
JI Eur. Arch. Psych. Clin. Neurosci.
PD DEC
PY 2019
VL 269
IS 8
BP 985
EP 992
DI 10.1007/s00406-018-0908-0
PG 8
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA JL2XG
UT WOS:000495394500013
PM 29808267
DA 2025-06-11
ER

PT J
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   Sabbe, B. G. C.
   Thys, E.
   Buitelaar, J. K.
   Verkes, R. J.
   Kahn, R. S.
TI Ziprasidone Vs Olanzapine in Recent-Onset Schizophrenia and
   Schizoaffective Disorder: Results of an 8-Week Double-Blind Randomized
   Controlled Trial
SO SCHIZOPHRENIA BULLETIN
LA English
DT Article
DE schizophrenia; antipsychotics; metabolic syndrome; schizophreniform
   disorder
ID 1ST-EPISODE SCHIZOPHRENIA; ANTIPSYCHOTIC-DRUGS; RATING-SCALE;
   RELIABILITY; RATIONALE; VALIDITY; CATIE
AB Introduction: Head-to-head comparisons of antipsychotics have predominantly included patients with chronic conditions. The aim of the present study was to compare the efficacy and tolerability of ziprasidone and olanzapine in patients with recent-onset schizophrenia. Methods: The study was an 8-week, double-blind, parallel-group, randomized, controlled multicenter trial (NCT00145444). Seventy-six patients with schizophreniform disorder, schizophrenia or schizoaffective disorder (diagnosis < 5 y), and a maximum lifetime antipsychotic treatment < 16 weeks participated in the study. Efficacy of ziprasidone (80-160 mg/d) and olanzapine 10-20 mg was measured using the Positive and Negative Syndrome Scale (PANSS), the Clinical Global Impression (CGI) Scale, the Calgary Depression Scale for Schizophrenia (CDSS), and the Heinrich Quality of Life Scale (HQLS); tolerability assessments included laboratory assessments, body weight, and electroencephalogram. Results: Olanzapine (n = 34) and ziprasidone (n = 39) showed equal efficacy as measured by the PANSS, CDSS, CGI, and HQLS. However, mean weight gain was significantly higher in the olanzapine group (6.8 vs 0.1 kg, P < .001). Ziprasidone was associated with decreasing levels of triglycerides, cholesterol, and transaminases, while these parameters increased in the olanzapine group (all P values < .05). There were no significant differences in fasting glucose and prolactin levels or in cardiac or sexual side effects. Patients on ziprasidone used biperiden for extrapyramidal side effects more frequently (P < .05). Discussion: The results of this study indicate that ziprasidone and olanzapine have comparable therapeutic efficacy but differ in their side effect profile. However, there is a risk of a type II error with this sample size. Clinically significant weight gain and laboratory abnormalities appear early after initiating treatment and are more prominent with olanzapine, while more patients on ziprasidone received anticholinergic drugs to treat extrapyramidal symptoms.
C1 [Grootens, K. P.; Buitelaar, J. K.; Verkes, R. J.] Radboud Univ Nijmegen Med Ctr, Donders Ctr Neurosci, Nijmegen, Netherlands.
   [van Veelen, N. M. J.; Kahn, R. S.] Univ Med Ctr, Utrecht, Netherlands.
   Katholieke Univ Leuven, Univ Psychiat Ctr, Kortenberg, Belgium.
   [Sabbe, B. G. C.; Thys, E.] Univ Antwerp, Collaborat Antwerp Psychiat Res Inst, Antwerp, Belgium.
C3 Radboud University Nijmegen; Utrecht University; Utrecht University
   Medical Center; KU Leuven; University of Antwerp
RP Grootens, KP (corresponding author), Canisius Wilhemina Hosp, Psychiat A15,POB 9015, NL-6500 GS Nijmegen, Netherlands.
EM ink.grootens@cwz.nl
RI Sabbe, Bernard/J-3598-2013; Verkes, Robbert/E-4603-2012; Buitelaar,
   Jan/AAY-7522-2020
FU Pfizer; Astra Zeneca; Janssen-Cilag; Eli Lilly; Lundbeck; Sanofi
   Synthelabo; Bristol-Myers Squibb; Glaxo Smith Kline; Novartis; Nycomed;
   Organon; Sanofi-Aventis
FX Pfizer. Grant from Astra Zeneca to R. J. V.Conflict of interest:
   Grootens-none, van Veelen-none. Peuskens has acted as a consultant and
   cooperated in clinical trials with AstraZeneca, Bristol-Myers Squibb,
   Eli Lilly, Janssen-Cilag, Lundbeck, Pfizer, and Sanofi Synthelabo. He
   has also received research grants from AstraZeneca, Janssen-Cilag, Eli
   Lilly, Lundbeck, and Sanofi Synthelabo. Sabbe has been a member of
   advisory board or received grants of, or was a speaker for,
   Bristol-Myers Squibb, Eli Lilly, Glaxo Smith Kline, Janssen-Cilag,
   Lundbeck, Novartis, Nycomed, Organon, Pfizer, and Sanofi-Aventis. Thys
   has cooperated in clinical trials with AstraZeneca, Bristol-Myers
   Squibb, Eli Lilly, Janssen-Cilag, Lundbeck, Pfizer, and Sanofi
   Synthelabo. Buitelaar has been a consultant to/member of advisory board
   of/and/or speaker for Janssen-Cilag BV, Eli Lilly, Bristol-Myers Squibb,
   Organon, UCB, Shire, Medice, Servier, Bioprojet, Pfizer, and Servier.
   Verkes has received grants from Pfizer and Eli Lilly. Kahn has received
   grants, received honoraria for education programs, or served as
   consultant for Astellas, AstraZeneca, BMS, Eli Lilly, Janssen-Cilag,
   Pfizer, Roche, and Sanofi-Aventis.
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NR 30
TC 42
Z9 47
U1 0
U2 12
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0586-7614
EI 1745-1701
J9 SCHIZOPHRENIA BULL
JI Schizophr. Bull.
PD MAR
PY 2011
VL 37
IS 2
BP 352
EP 361
DI 10.1093/schbul/sbp037
PG 10
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 726SB
UT WOS:000287745300019
PM 19542525
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU González-Estecha, M
   Trasobares, EM
   Tajima, K
   Cano, S
   Fernández, C
   López, JL
   Unzeta, B
   Arroyo, M
   Fuentenebro, F
AF Gonzalez-Estecha, Montserrat
   Trasobares, Elena M.
   Tajima, Kazuhiro
   Cano, Sara
   Fernandez, Cristina
   Luis Lopez, Jose
   Unzeta, Belen
   Arroyo, Manuel
   Fuentenebro, Filiberto
TI Trace elements in bipolar disorder
SO JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
LA English
DT Article; Proceedings Paper
CT 4th International Symposium on Trace Elements and Minerals in Medicine
   and Biology
CY JUN 09-12, 2010
CL St Petersburg, RUSSIA
SP Federat European Soc Trace Elements & Minerals (FESTEM), Russian Soc Trace Elements Med (RUSTEM), Ctr Biot Med
DE Lead; Cadmium; Copper; Zinc; Thallium; Bipolar disorder; Depression;
   Mania
ID ELEVATED HOMOCYSTEINE LEVELS; BLOOD LEAD LEVELS; CARDIOVASCULAR-DISEASE;
   METABOLIC SYNDROME; ANTIDEPRESSANT TREATMENT; GENERAL-POPULATION;
   COGNITIVE FUNCTION; SUBSTANCE-ABUSE; CUMULATIVE LEAD; ZINC
AB Introduction: Trace elements may play an important role in bipolar disorders. The objective of this study is to determine serum copper and zinc, blood lead and cadmium and urine lead, cadmium and thallium concentrations in patients diagnosed with bipolar disorders and to compare these levels with those of a healthy control group.
   Materials and methods: A total of 25 patients diagnosed with bipolar disorder and 29 healthy subjects participated in this study. Serum copper and zinc concentrations were measured using flame atomic absorption spectrometry; the blood lead and cadmium concentrations were measured by electrothermal atomization atomic absorption spectrometry with Zeeman background correction; urine lead, cadmium and thallium concentrations were measured by inductively coupled plasma mass spectrometry.
   Results: Median blood and urine lead and cadmium levels were significantly higher among the bipolar patients than among the control group: Blood lead (mu g/dL): patient median: 3.00 (IQR: 1.40-4.20): control median (mu g/dL): 2.20 (IQR: 0.90-3.00) p = 0.040. Blood cadmium (mu g/L): patient median: 0.39 (IQR: 0.10-1.15); control median: 0.10 (IQR: 0.10-0.17)p < 0.001. The median of cadmium (mu g/L) in patients who smoked (1.20 IQR: 0.44-2.30) was higher than that in non-smokers (0.12 IQR: 0.10-0.34) p < 0.001. There was a statistically significant increase (p = 0.001) in zinc levels among patients in the manic phase (mean 111.28, SD: 33.36 mu g/dL) with respect to the control group (mean 86.07, SD: 12.39 mu g/dL).
   Conclusions: The results suggest that there could be higher levels of some toxic trace elements in the group of patients with bipolar disorder than in the healthy control group. (C) 2010 Elsevier GmbH. All rights reserved.
C1 [Gonzalez-Estecha, Montserrat; Trasobares, Elena M.; Arroyo, Manuel] Hosp Clin San Carlos, Unidad Elementos Traza S Anal Clin, Trace Element Unit, Madrid 28040, Spain.
   [Gonzalez-Estecha, Montserrat; Trasobares, Elena M.; Arroyo, Manuel] Hosp Clin San Carlos, Dept Lab Med, Madrid 28040, Spain.
   [Tajima, Kazuhiro; Unzeta, Belen; Fuentenebro, Filiberto] Hosp Clin San Carlos, Dept Psychiat, Madrid 28040, Spain.
   [Cano, Sara; Fernandez, Cristina] Hosp Clin San Carlos, Dept Epidemiol, Madrid 28040, Spain.
   [Luis Lopez, Jose] Hosp Cent Def, Dept Toxicol, Madrid, Spain.
C3 Hospital Clinico San Carlos; Hospital Clinico San Carlos; Hospital
   Clinico San Carlos; Hospital Clinico San Carlos
RP González-Estecha, M (corresponding author), Hosp Clin San Carlos, Unidad Elementos Traza S Anal Clin, Trace Element Unit, C Prof Martin Lagos S-N, Madrid 28040, Spain.
EM montse@cmpx.net
RI Pérez, Cristina/I-2220-2015
OI UNZETA CONDE, BELEN/0000-0002-9179-1885
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NR 60
TC 45
Z9 48
U1 0
U2 19
PU ELSEVIER GMBH
PI MUNICH
PA HACKERBRUCKE 6, 80335 MUNICH, GERMANY
SN 0946-672X
J9 J TRACE ELEM MED BIO
JI J. Trace Elem. Med. Biol.
PY 2011
VL 25
SU 1
BP S78
EP S83
DI 10.1016/j.jtemb.2010.10.015
PG 6
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI); Conference Proceedings Citation Index - Science (CPCI-S)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 767UT
UT WOS:000290884500015
PM 21242074
DA 2025-06-11
ER

PT J
AU De Paula, GC
   Simoes, RF
   Garcia-Serrano, AM
   Duarte, JMN
AF De Paula, Gabriela C.
   Simoes, Rui F.
   Garcia-Serrano, Alba M.
   Duarte, Joao M. N.
TI High-fat and High-sucrose Diet-induced Hypothalamic Inflammation Shows
   Sex Specific Features in Mice
SO NEUROCHEMICAL RESEARCH
LA English
DT Article
DE Neuroinflammation; High fat; Sucrose; Reverse diet; Cytokines; Gliosis
ID METABOLIC SYNDROME; HORMONES; OBESITY; TESTOSTERONE; PREVALENCE;
   RESPONSES; INSULIN
AB Hypothalamic inflammation underlies diet-induced obesity and diabetes in rodent models. While diet normalization largely allows for recovery from metabolic impairment, it remains unknown whether long-term hypothalamic inflammation induced by obesogenic diets is a reversible process. In this study, we aimed at determining sex specificity of hypothalamic neuroinflammation and gliosis in mice fed a fat- and sugar-rich diet, and their reversibility upon diet normalization. Mice were fed a 60%-fat diet complemented by a 20% sucrose drink (HFHSD) for 3 days or 24 weeks, followed by a third group that had their diet normalized for the last 8 weeks of the study (reverse diet group, RevD). We determined the expression of pro- and anti-inflammatory cytokines, and of the inflammatory cell markers IBA1, CD68, GFAP and EMR1 in the hypothalamus, and analyzed morphology of microglia (IBA-1+ cells) and astrocytes (GFAP+ cells) in the arcuate nucleus. After 3 days of HFHSD feeding, male mice showed over-expression of IL-13, IL-18, IFN-gamma, CD68 and EMR1 and reduced expression of IL-10, while females showed increased IL-6 and IBA1 and reduced IL-13, compared to controls. After 24 weeks of HFHSD exposure, male mice showed a general depression in the expression of cytokines, with prominent reduction of TNF-alpha, IL-6 and IL-13, but increased TGF-beta, while female mice showed over-expression of IFN-gamma and IL-18. Furthermore, both female and male mice showed some degree of gliosis after HFHSD feeding for 24 weeks. In mice of both sexes, diet normalization after prolonged HFHSD feeding resulted in partial neuroinflammation recovery in the hypothalamus, but gliosis was only recovered in females. In sum, HFHSD-fed mice display sex-specific inflammatory processes in the hypothalamus that are not fully reversible after diet normalization.
C1 [De Paula, Gabriela C.; Simoes, Rui F.; Garcia-Serrano, Alba M.; Duarte, Joao M. N.] Lund Univ, Fac Med, Dept Expt Med Sci, Diabet & Brain Funct Unit, Lund, Sweden.
   [De Paula, Gabriela C.; Simoes, Rui F.; Garcia-Serrano, Alba M.; Duarte, Joao M. N.] Lund Univ, Fac Med, Wallenberg Ctr Mol Med, Lund, Sweden.
   [De Paula, Gabriela C.] Inst Res Biomed, Bellinzona, Switzerland.
C3 Lund University; Lund University; Universita della Svizzera Italiana
RP De Paula, GC (corresponding author), Lund Univ, Fac Med, Dept Expt Med Sci, Diabet & Brain Funct Unit, Lund, Sweden.; De Paula, GC (corresponding author), Lund Univ, Fac Med, Wallenberg Ctr Mol Med, Lund, Sweden.; De Paula, GC (corresponding author), Inst Res Biomed, Bellinzona, Switzerland.
EM gabriela.depaula@irb.usi.ch
RI Garcia-Serrano, Alba/U-5101-2019
OI de Paula, Gabriela Cristina/0000-0001-6453-2143
FU Lund University; Lund University Bioimaging Centre
FX The Lund University Bioimaging Centre is acknowledged for access to
   microscopy resources.
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NR 47
TC 2
Z9 2
U1 1
U2 5
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0364-3190
EI 1573-6903
J9 NEUROCHEM RES
JI Neurochem. Res.
PD DEC
PY 2024
VL 49
IS 12
BP 3356
EP 3366
DI 10.1007/s11064-024-04243-4
EA SEP 2024
PG 11
WC Biochemistry & Molecular Biology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Neurosciences & Neurology
GA K0E1J
UT WOS:001317370100001
PM 39302596
OA hybrid
DA 2025-06-11
ER

PT J
AU Semiz, M
   Yücel, H
   Kavakçi, Ö
   Yildirim, O
   Zorlu, A
   Yilmaz, MB
   Küçükdurmaz, Z
   Canan, F
AF Semiz, Murat
   Yucel, Hasan
   Kavakci, Onder
   Yildirim, Osman
   Zorlu, Ali
   Yilmaz, Mehmet Birhan
   Kucukdurmaz, Zekeriya
   Canan, Fatih
TI Atypical antipsychotic use is an independent predictor for the increased
   mean platelet volume in patients with schizophrenia: A preliminary study
SO JOURNAL OF RESEARCH IN MEDICAL SCIENCES
LA English
DT Article
DE Atypical antipsychotics; cardiovascular disease; mean platelet volume;
   schizophrenia
ID MYOCARDIAL-INFARCTION; METABOLIC SYNDROME; CARDIOVASCULAR RISK; MAJOR
   DEPRESSION; SIZE; HETEROGENEITY; RESPONSIVITY; MEDICATION; MANAGEMENT;
   DISORDERS
AB Background: Cardiovascular diseases, cardiovascular risk factors, and mortality due to these situations are more frequently encountered in schizophrenic patients when compared with the general population. The mean platelet volume (MPV) is a surrogate biomarker of the platelet activity and an useful prognostic test in cardiometabolic diseases. The aim of this study was to investigate what influenced MPV levels in patients with schizophrenia. Materials and Methods: We evaluated hospital records of 60 hospitalized schizophrenia patients. Thirty age-and sex-matched healthy control subjects were also included as a control group. Results: MPV levels were significantly higher in patients who were on atypical antipsychotic drugs than in patients who were not using any drug (9.2 +/- 0.8 vs. 8.6 +/- 0.8 fL, P = 0.016) and also higher than control group (9.2 +/- 0.8 vs. 8.1 +/- 0.9 fL, P < 0.001). Furthermore, patients who were not using antipsychotics had higher MPV than control group (8.6 +/- 0.8 vs. 8.1 +/- 0.9 fL, P = 0.036). Atypical antipsychotic use [Odds ratio (OR) = 6.152, 95% confidence interval (CI,) P = 0.003)] and platelet distribution width (OR = 0.989, 95% CI, P = 0.032) were associated with high MPV levels in univariate analysis. In multivariate logistic regression model, only atypical antipsychotics use (OR = 6.152, 95% CI, P = 0.003) was found to be independent predictor of high MPV levels after adjustment of other potential confounders (age, gender, presence of hypertension, diabetes mellitus, hyperlipidemia, and smoking). Conclusion: MPV seems to be influenced not only by schizophrenia itself but also by atypical antipsychotic drugs. It might be concluded that schizophrenic patients are under increased risk for cardiometabolic diseases and risk factors and this risk is higher in patients on atypical antipsychotic treatment.
C1 [Semiz, Murat] Sivas Numune Hosp, Psychiat Clin, TR-58140 Sivas, Turkey.
   [Yucel, Hasan; Zorlu, Ali; Yilmaz, Mehmet Birhan; Kucukdurmaz, Zekeriya] Cumhuriyet Univ, Sch Med, Sivas Dept Cardiol, Sivas, Turkey.
   [Kavakci, Onder] Cumhuriyet Univ, Sch Med, Sivas Dept Psychiat, Sivas, Turkey.
   [Yildirim, Osman] Abant Izzet Baysal Univ, Sch Med, Dept Psychiat, Bolu, Turkey.
   [Canan, Fatih] Bolu Izzet Baysal Mental Hlth Hosp, Psychiat Clin, Bolu, Turkey.
C3 Sivas Numune Hospital; Cumhuriyet University; Cumhuriyet University;
   Abant Izzet Baysal University; AIBU Bolu Izzet Baysal Education &
   Research Hospital
RP Semiz, M (corresponding author), Sivas Numune Hosp, Psychiat Clin, TR-58140 Sivas, Turkey.
EM drmuratsemiz@hotmail.com
RI Kavakci, Onder/AAA-1368-2020; Canan, Fatih/C-1622-2016; Yilmaz, Mehmet
   Birhan/Y-1372-2019
OI Yilmaz, Mehmet Birhan/0000-0002-8169-8628
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NR 40
TC 21
Z9 23
U1 0
U2 2
PU ISFAHAN UNIV MED SCIENCES
PI ISFAHAN
PA HEZARJERIB AVE, PO BOX 81745-319, ISFAHAN, 00000, IRAN
SN 1735-1995
EI 1735-7136
J9 J RES MED SCI
JI J. Res. Med. Sci.
PD JUL
PY 2013
VL 18
IS 7
BP 560
EP 565
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 267PQ
UT WOS:000328110300006
PM 24516487
DA 2025-06-11
ER

PT J
AU Kingsley, SF
   Seo, Y
   Wood, A
   Wani, KA
   Gonzalez, X
   Irazoqui, J
   Finkel, SE
   Tissenbaum, HA
AF Kingsley, Samuel F.
   Seo, Yonghak
   Wood, Alicia
   Wani, Khursheed A.
   Gonzalez, Xavier
   Irazoqui, Javier
   Finkel, Steven E.
   Tissenbaum, Heidi A.
TI Glucose-fed microbiota alters C. elegans intestinal epithelium
   and increases susceptibility to multiple bacterial pathogens
SO SCIENTIFIC REPORTS
LA English
DT Article
ID HEAT-SHOCK FACTOR; CAENORHABDITIS-ELEGANS; LIFE-SPAN; IMMUNE-RESPONSE;
   LONGEVITY; HEALTHSPAN; GENES; DIETS; MAPK
AB Overconsumption of dietary sugar can lead to many negative health effects including the development of Type 2 diabetes, metabolic syndrome, cardiovascular disease, and neurodegenerative disorders. Recently, the human intestinal microbiota, strongly associated with our overall health, has also been known to be affected by diet. However, mechanistic insight into the importance of the human intestinal microbiota and the effects of chronic sugar ingestion has not been possible largely due to the complexity of the human microbiome which contains hundreds of types of organisms. Here, we use an interspecies C. elegans/E. coli system, where E. coli are subjected to high sugar, then consumed by the bacterivore host C. elegans to become the microbiota. This glucose-fed microbiota results in a significant lifespan reduction accompanied by reduced healthspan (locomotion), reduced stress resistance, and changes in behavior and feeding. Lifespan reduction is also accompanied by two potential major contributors: increased intestinal bacterial density and increased concentration of reactive oxygen species. The glucose-fed microbiota accelerated the age-related development of intestinal cell permeability, intestinal distention, and dysregulation of immune effectors. Ultimately, the changes in the intestinal epithelium due to aging with the glucose-fed microbiota results in increased susceptibility to multiple bacterial pathogens. Taken together, our data reveal that chronic ingestion of sugar, such as a Western diet, has profound health effects on the host due to changes in the microbiota and may contribute to the current increased incidence of ailments including inflammatory bowel diseases as well as multiple age-related diseases.
C1 [Kingsley, Samuel F.; Seo, Yonghak; Wood, Alicia; Tissenbaum, Heidi A.] UMass Chan Med Sch, Dept Mol Cell & Canc Biol, Worcester, MA 01605 USA.
   [Wani, Khursheed A.; Gonzalez, Xavier; Irazoqui, Javier] UMass Chan Med Sch, Dept Microbiol & Physiol Syst, Worcester, MA 01605 USA.
   [Finkel, Steven E.] Univ Southern Calif, Dept Biol Sci, Mol & Computat Biol Sect, Los Angeles, CA 90089 USA.
   [Tissenbaum, Heidi A.] UMass Chan Med Sch, Program Mol Med, Worcester, MA 01605 USA.
C3 University of Massachusetts System; UMass Chan Medical School;
   University of Massachusetts Worcester; University of Massachusetts
   System; UMass Chan Medical School; University of Massachusetts
   Worcester; University of Southern California; University of
   Massachusetts System; UMass Chan Medical School; University of
   Massachusetts Worcester
RP Tissenbaum, HA (corresponding author), UMass Chan Med Sch, Dept Mol Cell & Canc Biol, Worcester, MA 01605 USA.; Tissenbaum, HA (corresponding author), UMass Chan Med Sch, Program Mol Med, Worcester, MA 01605 USA.
EM Heidi.Tissenbaum@umassmed.edu
RI Irazoqui, Javier/AGK-5868-2022; Gonzalez, Xavier/AHA-0902-2022
OI Gonzalez, Xavier/0000-0001-5546-8856
FU U.S. Army Research Office; NIH Office of Research Infrastructure
   Programs [P40 OD010440]; NIH/NIA [5R21AG067317, 3R21AG084042]; U.S. Air
   Force Office of Scientific Research [FA9550-23-1-0287]; William Randolph
   Hearst Foundation;  [W911NF1210321]
FX We are grateful to members of the Tissenbaum and Finkel labs for advice
   and suggestions, Susan Lee and Evelyn Caez for technical support, Dr.
   David Greenstein for advice and support, Dr. Emily Troemel for providing
   strains and Dr. Read Pukkila-Worley for providing strains and primer
   sequences and help with the P. aeruginosa experiments. Some of the C.
   elegans strains were kindly provided by the Caenorhabditis Genetics
   Center, which is funded by NIH Office of Research Infrastructure
   Programs (P40 OD010440). H.A.T. is a William Randolph Hearst
   Investigator. This project was funded by a Grant from the NIH/NIA
   (5R21AG067317, 3R21AG084042 to H.A.T. S.E.F. is supported by a Grant
   from the U.S. Army Research Office (W911NF1210321) and a grant from the
   U.S. Air Force Office of Scientific Research (FA9550-23-1-0287). H.A.T.
   is supported in part by an endowment from the William Randolph Hearst
   Foundation.
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NR 46
TC 1
Z9 1
U1 1
U2 7
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD JUN 7
PY 2024
VL 14
IS 1
AR 13177
DI 10.1038/s41598-024-63514-w
PG 12
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA TW8Z6
UT WOS:001244401200062
PM 38849503
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Zazula, MF
   Saraiva, DF
   Theodoro, JL
   Maciel, M
   Sepulveda, EVD
   de Andrade, BZ
   Boaretto, ML
   Maciel, JIHN
   Bronczek, GA
   Soares, GM
   Schneider, SCS
   Bertolini, GRF
   Torrejais, MM
   Ribeiro, LFC
   Fernandes, LC
   Naliwaiko, K
AF Zazula, Matheus Felipe
   Saraiva, Diego Francis
   Theodoro, Joao Lucas
   Maciel, Monica
   Sepulveda, Eliel Vieira dos Santos
   de Andrade, Barbara Zanardini
   Boaretto, Mariana Lais
   Maciel, Jhyslayne Ignacia Hoff Nunes
   Bronczek, Gabriela Alves
   Soares, Gabriela Moreira
   Schneider, Sara Cristina Sagae
   Bertolini, Gladson Ricardo Flor
   Torrejais, Marcia Miranda
   Ribeiro, Lucineia Fatima Chasko
   Fernandes, Luiz Claudio
   Naliwaiko, Katya
TI An Early and Sustained Inflammatory State Induces Muscle Changes and
   Establishes Obesogenic Characteristics in Wistar Rats Exposed to the
   MSG-Induced Obesity Model
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE hyperinsulinemia; monosodium glutamate; metabolic syndrome; distress
   oxidative; pro-inflammatory profile; skeletal muscle fiber types
ID WHOLE-BODY VIBRATION; MONOSODIUM GLUTAMATE; SKELETAL-MUSCLE;
   INSULIN-RESISTANCE; GLUCOSE-INTOLERANCE; OXIDATIVE STRESS; GROWTH;
   FEMALE; GH; SUPPLEMENTATION
AB The model of obesity induced by monosodium glutamate cytotoxicity on the hypothalamic nuclei is widely used in the literature. However, MSG promotes persistent muscle changes and there is a significant lack of studies that seek to elucidate the mechanisms by which damage refractory to reversal is established. This study aimed to investigate the early and chronic effects of MSG induction of obesity upon systemic and muscular parameters of Wistar rats. The animals were exposed to MSG subcutaneously (4 mg center dot g(-1) b.w.) or saline (1.25 mg center dot g(-1) b.w.) daily from PND01 to PND05 (n = 24). Afterwards, in PND15, 12 animals were euthanized to determine the plasma and inflammatory profile and to assess muscle damage. In PND142, the remaining animals were euthanized, and samples for histological and biochemical analyses were obtained. Our results suggest that early exposure to MSG reduced growth, increased adiposity, and inducted hyperinsulinemia and a pro-inflammatory scenario. In adulthood, the following were observed: peripheral insulin resistance, increased fibrosis, oxidative distress, and a reduction in muscle mass, oxidative capacity, and neuromuscular junctions, increased fibrosis, and oxidative distress. Thus, we can conclude that the condition found in adult life and the difficulty restoring in the muscle profile is related to the metabolic damage established early on.
C1 [Zazula, Matheus Felipe; Saraiva, Diego Francis; Theodoro, Joao Lucas; Maciel, Monica; Sepulveda, Eliel Vieira dos Santos; Naliwaiko, Katya] Univ Fed Parana, Dept Biol Celular, Lab Plasticidade Morfofunc, Setor Ciencias Biol, BR-81530000 Curitiba, Parana, Brazil.
   [de Andrade, Barbara Zanardini; Ribeiro, Lucineia Fatima Chasko] Univ Estadual Oeste Parana, Ctr Ciencias Biol & Saude, Lab Biol Estrutural & Func, BR-85819110 Cascavel, Parana, Brazil.
   [Boaretto, Mariana Lais; Maciel, Jhyslayne Ignacia Hoff Nunes; Bertolini, Gladson Ricardo Flor] Univ Estadual Oeste Parana, Ctr Ciencias Biol & Saude, Lab Estudo Lesoes & Recursos Fisioterapeut, BR-85819110 Cascavel, PR, Brazil.
   [Bronczek, Gabriela Alves; Soares, Gabriela Moreira] Univ Estadual Campinas, Ctr Pesquisa Obesidade & Comorb, Dept Biol Estrutural & Func, BR-13083970 Campinas, SP, Brazil.
   [Schneider, Sara Cristina Sagae] Univ Estadual Oeste Parana, Ctr Ciencias Biol & Saude, Lab Fisiol Endocrina & Metab, BR-85819110 Cascavel, Parana, Brazil.
   [Torrejais, Marcia Miranda] Univ Estadual Oeste Parana, Ctr Ciencias Med & Farmaceut, Lab Expt Morfol, BR-85819110 Cascavel, Parana, Brazil.
   [Fernandes, Luiz Claudio] Univ Fed Parana, Dept Fisiol, Lab Metab Celular, Setor Ciencias Biol, BR-81530000 Curitiba, Parana, Brazil.
C3 Universidade Federal do Parana; Universidade Estadual do Oeste do
   Parana; Universidade Estadual do Oeste do Parana; Universidade Estadual
   de Campinas; Universidade Estadual do Oeste do Parana; Universidade
   Estadual do Oeste do Parana; Universidade Federal do Parana
RP Zazula, MF; Naliwaiko, K (corresponding author), Univ Fed Parana, Dept Biol Celular, Lab Plasticidade Morfofunc, Setor Ciencias Biol, BR-81530000 Curitiba, Parana, Brazil.
EM matheuszazula@gmail.com; naliwaiko@gmail.com
RI Fernandes, Luiz/I-4907-2014; Naliwaiko, Katya/IVU-9006-2023; sagae
   schneider, sara/HNJ-4816-2023; Bertolini, Gladson/U-8283-2018; Zanardini
   de Andrade, Barbara/GZK-6449-2022; Zazula, Matheus Felipe/ABC-3768-2021
OI Maciel, Monica/0000-0003-2103-7315; Theodoro, Joao
   Lucas/0000-0002-6192-6347; Cristina Sagae Schneider,
   Sara/0009-0009-4732-9018; Bertolini, Gladson/0000-0003-0565-2019;
   Zanardini de Andrade, Barbara/0000-0003-0909-8668; Francis,
   Diego/0000-0002-4763-7610; Zazula, Matheus Felipe/0000-0002-4760-5977;
   Fernandes, Luiz/0000-0001-9919-0681
FU Universidade Federal do Parana; Universidade Estadual do Oeste do
   Parana; Universidade Estadual de Campinas; Fundacao Araucaria
   [016/2016]; Conselho Nacional de Desenvolvimento Cientifico e
   Tecnologico; Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior
FX This research was supported by the Universidade Federal do Parana,
   Universidade Estadual do Oeste do Parana and Universidade Estadual de
   Campinas. This research was funded by Fundacao Araucaria, grant number
   016/2016, Conselho Nacional de Desenvolvimento Cientifico e Tecnologico,
   and Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior.
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NR 68
TC 6
Z9 6
U1 0
U2 1
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD MAR
PY 2023
VL 24
IS 5
AR 4730
DI 10.3390/ijms24054730
PG 21
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 9U9JJ
UT WOS:000948019400001
PM 36902158
OA gold, Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU O'Keefe, EL
   Sturgess, JE
   O'Keefe, JH
   Gupta, S
   Lavie, CJ
AF O'Keefe, Evan L.
   Sturgess, Jessica E.
   O'Keefe, James H.
   Gupta, Sanjaya
   Lavie, Carl J.
TI Prevention and Treatment of Atrial Fibrillation via Risk Factor
   Modification
SO AMERICAN JOURNAL OF CARDIOLOGY
LA English
DT Article
ID ATHEROSCLEROSIS RISK; ALCOHOL-CONSUMPTION; PHYSICAL-ACTIVITY;
   LIFE-STYLE; FOLLOW-UP; PREVALENCE; OBESITY; MANAGEMENT; REDUCTION;
   PROGNOSIS
AB Atrial fibrillation (AF) is the most common clinically significant arrhythmia, and it increases stroke risk. A preventive approach to AF is needed because virtually all treatments such as cardioversion, antiarrhythmic drugs, ablation, and anticoagulation are associated with high cost and carry significant risk. A systematic review was performed to identify effective lifestyle-based strategies for reducing primary and secondary AF. A PubMed search was performed using articles up to March 1, 2021. Search terms included atrial fibrillation, atrial flutter, exercise, diet, metabolic syndrome, type 2 diabetes mellitus, obesity, hypertension, stress, tobacco smoking, alcohol, Mediterranean diet, sodium, and omega-3 fatty acids. Additional articles were identified from the bibliographies of retrieved articles. The control of hypertension, ideally with a renin-angiotensin-aldosterone system inhibitor, is effective for preventing primary AF and recurrence. Obstructive sleep apnea is a common cause of AF, and treating it effectively reduces AF episodes. Alcohol increases the risk of AF in a dose-dependent manner, and abstinence reduces risk of recurrence. Sedentary behavior and chronic high-intensity endurance exercise are both risk factors for AF; however, moderate physical activity is associated with lower risk of AF. Recently, sodium-glucose cotransporter-2 inhibitors and glucagon-like peptide-1 agonists have been associated with reduced risk of AF. Among overweight/obese patients, weight loss of >= 10% is associated with reduced AF risk. Lifestyle changes and risk factor modification are highly effective for preventing AF. (C) 2021 The Authors. Published by Elsevier Inc.
C1 [O'Keefe, Evan L.] Tulane Univ Med Ctr Hosp & Clin, New Orleans, LA USA.
   [Sturgess, Jessica E.; O'Keefe, James H.; Gupta, Sanjaya] Univ Missouri, Kansas City, MO 64110 USA.
   [O'Keefe, James H.; Gupta, Sanjaya] St Lukes Mid Amer Heart Inst, Kansas City, MO 64111 USA.
   [Lavie, Carl J.] Univ Queensland, John Ochsner Heart & Vasc Inst, Ochsner Clin Sch, Sch Med, New Orleans, LA USA.
C3 Tulane University; Tulane University Hospital; University of Missouri
   System; University of Missouri Kansas City; Saint Luke's Mid America
   Heart Institute; Ochsner Health System; University of Queensland
RP O'Keefe, JH (corresponding author), Univ Missouri, Kansas City, MO 64110 USA.; O'Keefe, JH (corresponding author), St Lukes Mid Amer Heart Inst, Kansas City, MO 64111 USA.
EM jokeefe@saintlukeskc.org
RI Lavie, Carl/A-6014-2011
OI O'Keefe, James/0000-0002-3376-5822; Gupta, Sanjaya/0000-0002-1789-4712
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NR 55
TC 33
Z9 34
U1 2
U2 10
PU EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
PI BRIDGEWATER
PA 685 ROUTE 202-206 STE 3, BRIDGEWATER, NJ 08807 USA
SN 0002-9149
EI 1879-1913
J9 AM J CARDIOL
JI Am. J. Cardiol.
PD DEC 1
PY 2021
VL 160
BP 46
EP 52
DI 10.1016/j.amjcard.2021.08.042
EA NOV 2021
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA WV8IX
UT WOS:000717475200007
PM 34583808
OA hybrid
DA 2025-06-11
ER

PT J
AU Fini, MA
   Lanaspa, MA
   Gaucher, EA
   Boutwell, B
   Nakagawa, T
   Wright, RM
   Sanchez-Lozada, LG
   Andrews, P
   Stenmark, KR
   Johnson, RJ
AF Fini, Mehdi A.
   Lanaspa, Miguel A.
   Gaucher, Eric A.
   Boutwell, Brian
   Nakagawa, Takahiko
   Wright, Richard M.
   Sanchez-Lozada, Laura G.
   Andrews, Peter
   Stenmark, Kurt R.
   Johnson, Richard J.
TI Brief report: The uricase mutation in humans increases our risk for
   cancer growth
SO CANCER & METABOLISM
LA English
DT Article
DE Obesity; Tumor growth; Fructose; Uric acid; Uricase; Thrifty gene
ID POTENTIAL-ROLE; FRUCTOSE; ACID; INHIBITION; SUGAR
AB Background Recent studies suggest that fructose, as well as its metabolite, uric acid, have been associated with increased risk for both cancer incidence and growth. Both substances are known to cause oxidative stress to mitochondria and to reduce adenosine triphosphate (ATP) production by blocking aconitase in the Krebs cycle. The uricase mutation that occurred in the Miocene has been reported to increase serum uric acid and to amplify the effects of fructose to stimulate fat accumulation. Here we tested whether the uricase mutation can also stimulate tumor growth. Methods Experiments were performed in mice in which uricase was inactivated by either knocking out the gene or by inhibiting uricase with oxonic acid. We also studied mice transgenic for uricase. These mice were injected with breast cancer cells and followed for 4 weeks. Results The inhibition or knockout of uricase was associated with a remarkable increase in tumor growth and metastases. In contrast, transgenic uricase mice showed reduced tumor growth. Conclusion A loss of uricase increases the risk for tumor growth. Prior studies have shown that the loss of the mutation facilitated the ability of fructose to increase fat which provided a survival advantage for our ancestors that came close to extinction from starvation in the mid Miocene. Today, however, excessive fructose intake is rampant and increasing our risk not only for obesity and metabolic syndrome, but also cancer. Obesity-associated cancer may be due, in part, to a mutation 15 million years ago that acted as a thrifty gene.
C1 [Fini, Mehdi A.; Wright, Richard M.; Stenmark, Kurt R.] Univ Colorado, Div Pulm & Crit Care Med, Anschulz Med Ctr,RC2,Room 8120,Mail Stop B-133, Aurora, CO 80045 USA.
   [Lanaspa, Miguel A.; Johnson, Richard J.] Univ Colorado, Div Renal Dis & Hypertens, Anschulz Med Ctr, Aurora, CO USA.
   [Gaucher, Eric A.] Georgia State Univ, Dept Biol, Atlanta, GA USA.
   [Boutwell, Brian] Univ Mississippi, Sch Appl Sci, Jackson, MI USA.
   [Boutwell, Brian] Univ Mississippi, John D Bower Sch Populat Hlth, Jackson, MI USA.
   [Nakagawa, Takahiko] Rakuwakai Otowa Hosp, Dept Nephrol, Kyoto, Japan.
   [Sanchez-Lozada, Laura G.] INC Ignacio Chavez, Dept Cardiorenal Physiopathol, Mexico City, DF, Mexico.
   [Andrews, Peter] Nat Hist Museum, Dept Earth Sci, London, England.
   [Stenmark, Kurt R.] Univ Colorado, Dept Pediat, Anschutz Med Ctr, Aurora, CO USA.
   [Johnson, Richard J.] Rocky Mt VA Med Ctr, Aurora, CO USA.
C3 University of Colorado System; University of Colorado Anschutz Medical
   Campus; University of Colorado System; University of Colorado Anschutz
   Medical Campus; University System of Georgia; Georgia State University;
   University of Mississippi; University of Mississippi; Natural History
   Museum London; University of Colorado System; University of Colorado
   Anschutz Medical Campus
RP Fini, MA (corresponding author), Univ Colorado, Div Pulm & Crit Care Med, Anschulz Med Ctr,RC2,Room 8120,Mail Stop B-133, Aurora, CO 80045 USA.
EM Mehdi.Fini@caunschutz.edu
RI Lanaspa, Miguel/AAO-4971-2020; Gaucher, Eric/I-7313-2013;
   Sanchez-Lozada, Laura/AAS-2104-2021; stenmark, kurt/AFI-6776-2022
OI Johnson, Richard/0000-0003-3312-8193
FU National Institutes of Health [HL014985, DK121496]; National Institute
   of Diabetes and Digestive and Kidney Diseases [R01DK121496] Funding
   Source: NIH RePORTER
FX This work was supported, in whole or in part, by National Institutes of
   Health Grant HL014985 (KS) and DK121496 (RJ and ML).
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NR 23
TC 13
Z9 13
U1 1
U2 8
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 2049-3002
J9 CANCER METAB
JI Cancer Metab.
PD SEP 15
PY 2021
VL 9
IS 1
AR 32
DI 10.1186/s40170-021-00268-3
PG 5
WC Oncology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Cell Biology
GA UQ6UB
UT WOS:000696196800001
PM 34526149
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Dai, W
   Choubey, M
   Patel, S
   Singer, HA
   Ozcan, L
AF Dai, Wen
   Choubey, Mayank
   Patel, Sonal
   Singer, Harold A.
   Ozcan, Lale
TI Adipocyte CAMK2 deficiency improves obesity-associated glucose
   intolerance
SO MOLECULAR METABOLISM
LA English
DT Article
DE CAMK2; Adipose tissue; Obesity; Glucose intolerance; Insulin resistance;
   Insulin signaling; Lipolysis; Adipocyte inflammation
ID INSULIN-RESISTANCE; KINASE-II; METABOLIC SYNDROME; OXIDATIVE STRESS;
   RECEPTOR; CALCIUM; MICE; FAT; PHOSPHORYLATION; CONTRIBUTES
AB Objective: Obesity-related adipose tissue dysfunction has been linked to the development of insulin resistance, type 2 diabetes, and cardiovascular disease. Impaired calcium homeostasis is associated with altered adipose tissue metabolism; however, the molecular mechanisms that link disrupted calcium signaling to metabolic regulation are largely unknown. Here, we investigated the contribution of a calcium-sensing enzyme, calcium/calmodulin-dependent protein kinase II (CAMK2), to adipocyte function, obesity-associated insulin resistance, and glucose intolerance. Methods: To determine the impact of adipocyte CAMK2 deficiency on metabolic regulation, we generated a conditional knockout mouse model and acutely deleted CAMK2 in mature adipocytes. We further used in vitro differentiated adipocytes to dissect the mechanisms by which CAMK2 regulates adipocyte function. Results: CAMK2 activity was increased in obese adipose tissue, and depletion of adipocyte CAMK2 in adult mice improved glucose intolerance and insulin resistance without an effect on body weight. Mechanistically, we found that activation of CAMK2 disrupted adipocyte insulin signaling and lowered the amount of insulin receptor. Further, our results revealed that CAMK2 contributed to adipocyte lipolysis, tumor necrosis factor alpha (TNFa)-induced inflammation, and insulin resistance. Conclusions: These results identify a new link between adipocyte CAMK2 activity, metabolic regulation, and whole-body glucose homeostasis. (c) 2021 The Author(s). Published by Elsevier GmbH. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
C1 [Dai, Wen; Choubey, Mayank; Patel, Sonal; Ozcan, Lale] Columbia Univ, Dept Med, Irving Med Ctr, New York, NY USA.
   [Dai, Wen] Cent South Univ, Xiangya Hosp 2, Dept Cardiol, Changsha, Peoples R China.
   [Singer, Harold A.] Albany Med Coll, Dept Mol & Cellular Physiol, Albany, NY 12208 USA.
C3 NewYork-Presbyterian Hospital; Columbia University; Central South
   University; Albany Medical College
RP Ozcan, L (corresponding author), 630 West 168th St,Black Bldg 901D, New York, NY 10032 USA.
EM lo2192@cumc.columbia.edu
RI Patel, Sonal/ABI-8347-2020; Choubey, Mayank/S-3286-2019
OI Ozcan, Lale/0000-0002-2710-7057; Choubey, Mayank/0000-0002-2350-0855
FU NIH [DK106045, DK124457, HL049426]; China Scholarship Council
   [201806370080]
FX The authors would like to thank Dr. Eric N. Olson and his lab (UT
   Southwestern) for providing the Camk2gfl/fl and Camk2dfl/fl mice. This
   work was supported by NIH grants DK106045 and DK124457 to L.O., HL049426
   to H.A.S., and a State Scholarship Fund from China Scholarship Council
   (201806370080) to W.D.
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NR 69
TC 33
Z9 35
U1 1
U2 17
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2212-8778
J9 MOL METAB
JI Mol. Metab.
PD NOV
PY 2021
VL 53
AR 101300
DI 10.1016/j.molmet.2021.101300
EA AUG 2021
PG 14
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA WA4QC
UT WOS:000702870200003
PM 34303021
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Grabia, M
   Puscion-Jakubik, A
   Markiewicz-Zukowska, R
   Bielecka, J
   Mielech, A
   Nowakowski, P
   Socha, K
AF Grabia, Monika
   Puscion-Jakubik, Anna
   Markiewicz-Zukowska, Renata
   Bielecka, Joanna
   Mielech, Anita
   Nowakowski, Patryk
   Socha, Katarzyna
TI Adherence to Mediterranean Diet and Selected Lifestyle Elements among
   Young Women with Type 1 Diabetes Mellitus from Northeast Poland: A
   Case-Control COVID-19 Survey
SO NUTRIENTS
LA English
DT Article
DE diabetes mellitus; Mediterranean diet; COVID-19; dietary pattern;
   metabolic disease; women; nutritional habits; health behaviors;
   lifestyle; obesity
ID METABOLIC SYNDROME; INSULIN-RESISTANCE; RISK-FACTORS; OVERWEIGHT;
   CHILDREN; OBESITY; POLYPHENOLS; ADOLESCENTS; WEIGHT; ADULTS
AB An appropriate balanced diet and dietary patterns are important at every stage of life, but in the case of young patients with type 1 diabetes mellitus (T1DM), it is especially crucial during the COVID-19 pandemic. The aim of the study was to assess health and nutritional behaviors, mainly adherence to the Mediterranean diet (MD), during the second wave of the COVID-19 pandemic in Poland among women with T1DM, and to compare them with a healthy population. This survey (based on a questionnaire) was conducted in December 2020 and included 219 young women, healthy (n = 106) and with T1DM (n = 113), from northeast Poland. Over 30% of the study group admitted that they did not engage in any physical activity. A large proportion declared that their screen time was 5-7 h a day (48% in control and 40% in T1DM group). High intakes of sweet-beverages, sweets and red meat, but also low intakes of olive oil, fish and nuts were observed. The vast majority of participants (60% vs. 71%) were moderately adherent to the Mediterranean Diet Adherence Screener (MEDAS). The study demonstrated that despite the similarity between the behaviors of healthy people and those with T1DM, negative health and nutritional practices, such as low physical activity, long screen time, medium and high levels of stress and inappropriate eating habits were observed.
C1 [Grabia, Monika; Puscion-Jakubik, Anna; Markiewicz-Zukowska, Renata; Bielecka, Joanna; Mielech, Anita; Nowakowski, Patryk; Socha, Katarzyna] Med Univ Bialystok, Fac Pharm, Dept Bromatol, Div Lab Med, Mickiewicza 2D St, PL-15222 Bialystok, Poland.
C3 Medical University of Bialystok
RP Markiewicz-Zukowska, R (corresponding author), Med Univ Bialystok, Fac Pharm, Dept Bromatol, Div Lab Med, Mickiewicza 2D St, PL-15222 Bialystok, Poland.
EM monika.grabia@umb.edu.pl; anna.puscion-jakubik@umb.edu.pl;
   renmar@poczta.onet.pl; joanna.bielecka@umb.edu.pl;
   anita.mielech@umb.edu.pl; patryk.nowakowski@umb.edu.pl;
   katarzyna.socha@umb.edu.pl
RI Mielech, Anita/JHU-7727-2023; Bielecka, Joanna/IQS-1816-2023;
   Grabia-Lis, Monika/AAQ-3817-2021
OI Puscion-Jakubik, Anna/0000-0002-8526-8107; Grabia-Lis,
   Monika/0000-0002-2230-9143; Bielecka, Joanna/0000-0003-4436-5434;
   Markiewicz Zukowska, Renata/0000-0003-0716-9573; Zmudzinska,
   Anita/0000-0002-8415-5450; Nowakowski, Patryk/0000-0002-2504-6879;
   Socha, Katarzyna/0000-0002-5949-7061
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NR 42
TC 7
Z9 8
U1 0
U2 5
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD APR
PY 2021
VL 13
IS 4
AR 1173
DI 10.3390/nu13041173
PG 15
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA RR8NJ
UT WOS:000643347800001
PM 33918177
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU McDade, TW
   Koning, SM
AF McDade, Thomas W.
   Koning, Stephanie M.
TI Early origins of socioeconomic inequalities in chronic inflammation:
   Evaluating the contributions of low birth weight and short breastfeeding
SO SOCIAL SCIENCE & MEDICINE
LA English
DT Article
DE Health disparities; C-reactive protein; Life course; Biosocial;
   Developmental origins of health and disease
ID C-REACTIVE PROTEIN; EARLY-LIFE STRESS; IN-UTERO; HEALTH DISPARITIES;
   MATERNAL RECALL; BLOOD-PRESSURE; UNITED-STATES; ADULT HEALTH; CHILDHOOD;
   RISK
AB The United States is characterized by persistent and widening social inequities in a wide range of adult health outcomes. A life course approach challenges us to consider if, and how, these inequities trace back to early life conditions, and chronic inflammation represents a potentially important mechanism through which early environments may have lasting effects on health in adulthood. Low birth weight (LBW) and shorter durations of breastfeeding both predict increased inflammation in adulthood, which is associated with increased risk for cardiovascular disease, metabolic syndrome, and all-cause mortality. Using data from a large representative sample of young adults in the US (National Longitudinal Study of Adolescent to Adult Health (Add Health)), we document the socioeconomic status (SES) gradient in chronic inflammation, as indicated by concentrations of C-reactive protein (CRP). Using a nested set of structural equation models and marginal standardization techniques, we investigate the extent to which this gradient is explained by patterns of LBW and breastfeeding in infancy. Findings reveal a particularly important role for breastfeeding duration: Based on model predictive margins, increasing breastfeeding duration to three or more months corresponds to a flattening of the SES gradient by 80%, and 83% when LBW is eliminated. This study expands current understandings of the consequential role of developmental environments for population health and for addressing health inequities in future generations.
C1 [McDade, Thomas W.] Northwestern Univ, Dept Anthropol, Evanston, IL 60208 USA.
   [McDade, Thomas W.; Koning, Stephanie M.] Northwestern Univ, Inst Policy Res, Evanston, IL 60208 USA.
   [McDade, Thomas W.] Canadian Inst Adv Res, Child & Brain Dev Program, Toronto, ON M5G 1Z8, Canada.
C3 Northwestern University; Northwestern University; Canadian Institute for
   Advanced Research (CIFAR)
RP McDade, TW (corresponding author), Northwestern Univ, Dept Anthropol, Evanston, IL 60208 USA.
EM t-mcdade@northwestern.edu
RI Koning, Stephanie/LLM-4907-2024
OI McDade, Thomas/0000-0001-5829-648X; Koning, Stephanie
   M./0000-0003-0673-2483
FU Eunice Kennedy Shriver National Institute of Child Health and Human
   Development of the National Institutes of Health [R21HD101757,
   P01-HD31921]; Eunice Kennedy Shriver National Institute of Child Health
   and Human Development; Eunice Kennedy Shriver National Institute of
   Child Health and Human Development [R21HD101757] Funding Source: NIH
   RePORTER
FX Research reported in this publication was supported by the Eunice
   Kennedy Shriver National Institute of Child Health and Human Development
   of the National Institutes of Health under Award Number R21HD101757. The
   content is solely the responsibility of the authors and does not
   necessarily represent the official views of the National Institutes of
   Health. This research uses data from Add Health, a program project
   directed by Kathleen Mullan Harris and designed by J. Richard Udry,
   Peter S. Bearman, and Kathleen Mullan Harris at the University of North
   Carolina at Chapel Hill, and funded by grant P01-HD31921 from the Eunice
   Kennedy Shriver National Institute of Child Health and Human
   Development, with cooperative funding from 23 other federal agencies and
   foundations. Information on how to obtain the Add Health data files is
   available on the Add Health website
   (https://dev-addhealth.cpc.unc.edu/).No direct support was received from
   grant P01-HD31921 for this analysis.
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NR 107
TC 21
Z9 22
U1 0
U2 8
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0277-9536
EI 1873-5347
J9 SOC SCI MED
JI Soc. Sci. Med.
PD JAN
PY 2021
VL 269
AR 113592
DI 10.1016/j.socscimed.2020.113592
PG 9
WC Public, Environmental & Occupational Health; Social Sciences, Biomedical
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; Biomedical Social Sciences
GA PN6KH
UT WOS:000604585400024
PM 33360022
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Siddiqi, SM
   Sun, CH
   Wu, XY
   Shah, I
   Mehmood, A
AF Siddiqi, Sultan Mehmood
   Sun, Changhao
   Wu, Xiaoyan
   Shah, Imranullah
   Mehmood, Anam
TI The Correlation between Dietary Selenium Intake and Type 2 Diabetes: A
   Cross-Sectional Population-Based Study on North Chinese Adults
SO BIOMED RESEARCH INTERNATIONAL
LA English
DT Article
ID FASTING PLASMA-GLUCOSE; SERUM SELENIUM; INSULIN-RESISTANCE;
   RISK-FACTORS; GLUTATHIONE-PEROXIDASE; METABOLIC SYNDROME; OXIDATIVE
   STRESS; TOENAIL SELENIUM; PROSTATE-CANCER; SELENOPROTEIN P
AB The relationship between selenium (Se) and type 2 diabetes (T2D) remains controversial. In previous animal and cell studies, Se was found to be insulin mimic and antidiabetic, whereas recent epidemiological and interventional trials have shown an unexpected association between high Se intake and increased risk of T2D. The present study aimed to investigate the significance of dietary Se and T2D in North Chinese adults. A large sample of the population was enrolled through cluster sampling in Northern China (N=8824). Information on basic characteristics, anthropometric measures, and dietary Se intake was collected from each subject for analysis. Multivariable logistic regression was used to investigate the association between dietary Se and T2D through adjusted odds ratio (OR) and the corresponding 95% confidence interval (CI). The average nutritional Se intake was 52.43 mu g/day, and the prevalence of T2D was 20.4% in the studied population. The OR for developing T2D was 1.66 (95% CI: 1.38, 1.99; P for linear trend <0.005), comparing the highest to the lowest quintile of energy-adjusted Se intake in multivariate logistic regression analysis. The mediation analysis discovered that glucose metabolism (indicated by FBG and HbA1c) mediated this association. In conclusion, our research adds further support to the role of high dietary Se in the incidence of T2D. The results also suggested that this association was mediated by glucose metabolism.
C1 [Siddiqi, Sultan Mehmood; Sun, Changhao; Wu, Xiaoyan; Shah, Imranullah] Harbin Med Univ, Coll Publ Hlth, Dept Nutr & Food Hyg, Harbin 150081, Heilongjiang, Peoples R China.
   [Mehmood, Anam] Harbin Med Univ, Coll Publ Hlth, Dept Clin Psychol, Harbin 150081, Heilongjiang, Peoples R China.
C3 Harbin Medical University; Harbin Medical University
RP Sun, CH (corresponding author), Harbin Med Univ, Coll Publ Hlth, Dept Nutr & Food Hyg, Harbin 150081, Heilongjiang, Peoples R China.
EM smsiddiqi@hrbmu.edu.cn; sun2002changhao@126.com; wxywxy_79@126.com;
   imranshah231@yahoo.com; anam_siddiqi@yahoo.com
FU National Key R&D Program of China [2017YFC1307401]
FX The authors are indebted to the participants of HDNNCDS for their
   continued cooperation and participation. The National Key R&D Program of
   China (2017YFC1307401 to Changhao Sun) provided financial support for
   this study.
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NR 67
TC 31
Z9 33
U1 1
U2 15
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2314-6133
EI 2314-6141
J9 BIOMED RES INT
JI Biomed Res. Int.
PD JAN 22
PY 2020
VL 2020
AR 8058463
DI 10.1155/2020/8058463
PG 10
WC Biotechnology & Applied Microbiology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Research & Experimental Medicine
GA KH8QB
UT WOS:000510914400011
PM 32076615
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Zahid, A
   Li, BF
   Kombe, AJK
   Jin, TC
   Tao, JH
AF Zahid, Ayesha
   Li, Bofeng
   Kombe, Arnaud John Kombe
   Jin, Tengchuan
   Tao, Jinhui
TI Pharmacological Inhibitors of the NLRP3 Inflammasome
SO FRONTIERS IN IMMUNOLOGY
LA English
DT Review
DE NLRP3 inflammasome; inhibitors; MCC950; drug screening; IL-1 beta
ID NF-KAPPA-B; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; BINDING CASSETTE
   TRANSPORTER; MURINE EXPERIMENTAL COLITIS; ATP-BINDING; BAY 11-7082;
   ANTIBACTERIAL ACTIVITY; NALP3 INFLAMMASOME; MOUSE MODEL; CELL-DEATH
AB Inflammasomes play a crucial role in innate immunity by serving as signaling platforms which deal with a plethora of pathogenic products and cellular products associated with stress and damage. By far, the best studied and most characterized inflammasome is NLRP3 inflammasome, which consists of NLRP3 (nucleotide-binding domain leucine-rich repeat (NLR) and pyrin domain containing receptor 3), ASC (apoptosis-associated speck-like protein containing a caspase recruitment domain), and procaspase-1. Activation of NLRP3 inflammasome is mediated by highly diverse stimuli. Upon activation, NLRP3 protein recruits the adapter ASC protein, which recruits the procaspase-1 resulting in its cleavage and activation, inducing the maturation, and secretion of inflammatory cytokines and pyroptosis. However, aberrant activation of the NLRP3 inflammasome is implicated in various diseases including diabetes, atherosclerosis, metabolic syndrome, cardiovascular, and neurodegenerative diseases; raising a tremendous clinical interest in exploring the potential inhibitors of NLRP3 inflammasome. Recent investigations have disclosed various inhibitors of the NLRP3 inflammasome pathway which were validated through in vitro studies and in vivo experiments in animal models of NLRP3-associated disorders. Some of these inhibitors directly target the NLRP3 protein whereas some are aimed at other components and products of the inflammasome. Direct targeting of NLRP3 protein can be a better choice because it can prevent off target immunosuppressive effects, thus restrain tissue destruction. This paper will review the various pharmacological inhibitors of the NLRP3 inflammasome and will also discuss their mechanism of action.
C1 [Zahid, Ayesha; Li, Bofeng; Jin, Tengchuan; Tao, Jinhui] Univ Sci & Technol China, Div Life Sci & Med, Affiliated Hosp USTC 1, Dept Rheumatol & Immunol, Hefei, Anhui, Peoples R China.
   [Zahid, Ayesha; Li, Bofeng; Kombe, Arnaud John Kombe; Jin, Tengchuan] Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, CAS Key Lab Innate Immun & Chron Dis, Div Life Sci & Med,Div Mol Med, Hefei, Anhui, Peoples R China.
   [Jin, Tengchuan] CAS Ctr Excellence Mol Cell Sci, Shanghai, Peoples R China.
C3 Chinese Academy of Sciences; University of Science & Technology of
   China, CAS; Chinese Academy of Sciences; University of Science &
   Technology of China, CAS; Chinese Academy of Sciences; Center for
   Excellence in Molecular Cell Science, CAS
RP Jin, TC; Tao, JH (corresponding author), Univ Sci & Technol China, Div Life Sci & Med, Affiliated Hosp USTC 1, Dept Rheumatol & Immunol, Hefei, Anhui, Peoples R China.; Jin, TC (corresponding author), Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, CAS Key Lab Innate Immun & Chron Dis, Div Life Sci & Med,Div Mol Med, Hefei, Anhui, Peoples R China.; Jin, TC (corresponding author), CAS Ctr Excellence Mol Cell Sci, Shanghai, Peoples R China.
EM jint@ustc.edu.cn; taojinhui@ustc.edu.cn
RI tao, jinhui/AAA-8818-2020; KOMBE KOMBE, Arnaud John/AAF-4919-2019; jin,
   Tengchuan/B-5883-2014
OI KOMBE KOMBE, Arnaud John/0000-0003-1533-1913; li,
   bofeng/0000-0002-9110-8804; jin, Tengchuan/0000-0002-1395-188X
FU Strategic Priority Research Program of the Chinese Academy of Sciences
   [XDB29030104]; National Natural Science Fund [31870731, U1732109];
   Fundamental Research Funds for the Central Universities; 100 Talents
   Programme of the Chinese Academy of Sciences; CAS-TWAS fellowship;
   Chinese Government Scholarship; National Natural Science Foundation of
   China [81771774]; Anhui Provincial Natural Science Foundation
   [1708085MH191]; Key Projects of Research and Development Program of
   Anhui Provence [201904a07020103]
FX TJ was supported by the Strategic Priority Research Program of the
   Chinese Academy of Sciences (Grant No. XDB29030104), the National
   Natural Science Fund (Grant No. 31870731 and U1732109), the Fundamental
   Research Funds for the Central Universities, and the 100 Talents
   Programme of the Chinese Academy of Sciences. AZ was supported by
   CAS-TWAS fellowship. AK was supported by Chinese Government Scholarship.
   JT was supported by the National Natural Science Foundation of China
   (81771774), the Anhui Provincial Natural Science Foundation
   (1708085MH191), and the Key Projects of Research and Development Program
   of Anhui Provence (201904a07020103).
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NR 120
TC 520
Z9 576
U1 13
U2 183
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-3224
J9 FRONT IMMUNOL
JI Front. Immunol.
PD OCT 25
PY 2019
VL 10
AR 2538
DI 10.3389/fimmu.2019.02538
PG 10
WC Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology
GA JJ9BZ
UT WOS:000494448100001
PM 31749805
OA gold, Green Published
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Kupcová, V
   Fedelesová, M
   Bulas, J
   Kozmonová, P
   Turecky, L
AF Kupcova, Viera
   Fedelesova, Michaela
   Bulas, Jozef
   Kozmonova, Petra
   Turecky, Ladislav
TI Overview of the Pathogenesis, Genetic, and Non-Invasive Clinical,
   Biochemical, and Scoring Methods in the Assessment of NAFLD
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Review
DE nonalcoholic fatty liver disease (NAFLD); steatosis; nonalcoholic
   steatohepatitis (NASH); fibrosis; biochemical diagnostic; genetic
   diagnostic; non-invasive scoring methods
ID FATTY LIVER-DISEASE; MAGNETIC-RESONANCE ELASTOGRAPHY; RADIATION FORCE
   IMPULSE; NONALCOHOLIC STEATOHEPATITIS; METABOLIC SYNDROME;
   INSULIN-RESISTANCE; HEPATIC STEATOSIS; ADVANCED FIBROSIS;
   HEPATOCELLULAR-CARCINOMA; CONFERS SUSCEPTIBILITY
AB Nonalcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease worldwide. It represents a range of disorders, including simple steatosis, nonalcoholic steatohepatitis (NASH), and liver cirrhosis, and its prevalence continues to rise. In some cases, hepatocellular carcinoma (HCC) may develop. The develop;ment of non-invasive diagnostic and screening tools is needed, in order to reduce the frequency of liver biopsies. The most promising methods are those able to exclude advanced fibrosis and quantify steatosis. In this study, new perspective markers for inflammation, oxidative stress, apoptosis, and fibrogenesis; emerging scoring models for detecting hepatic steatosis and fibrosis; and new genetic, epigenetic, and multiomic studies are discussed. As isolated biochemical parameters are not specific or sensitive enough to predict the presence of NASH and fibrosis, there is a tendency to use various markers and combine them into mathematical algorithms. Several predictive models and scoring systems have been developed. Current data suggests that panels of markers (NAFLD fibrosis score, Fib-4 score, BARD score, and others) are useful diagnostic modalities to minimize the number of liver biopsies. The review unveils pathophysiological aspects related to new trends in current non-invasive biochemical, genetic, and scoring methods, and provides insight into their diagnostic accuracies and suitability in clinical practice.
C1 [Kupcova, Viera; Fedelesova, Michaela; Kozmonova, Petra] Comenius Univ, Univ Hosp, Fac Med, Dept Internal Med 3, Bratislava 83305, Slovakia.
   [Bulas, Jozef] Comenius Univ, Univ Hosp, Fac Med, Dept Internal Med 1, Bratislava 81369, Slovakia.
   [Turecky, Ladislav] Comenius Univ, Fac Med, Inst Chem Biochem & Clin Biochem, Bratislava 81372, Slovakia.
C3 Slovak Medical University Bratislava; Comenius University Bratislava;
   Slovak Medical University Bratislava; Comenius University Bratislava;
   Comenius University Bratislava
RP Turecky, L (corresponding author), Comenius Univ, Fac Med, Inst Chem Biochem & Clin Biochem, Bratislava 81372, Slovakia.
EM ladislav.turecky@fmed.uniba.sk
FU Scientific Grant Agency of the Ministry of Education of Slovak Republic
   [VEGA 1/0826/18, VEGA 1/0807/18]
FX This work was supported by Scientific Grant Agency of the Ministry of
   Education of Slovak Republic VEGA 1/0826/18 and VEGA 1/0807/18.
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NR 194
TC 33
Z9 37
U1 0
U2 6
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD OCT
PY 2019
VL 16
IS 19
AR 3570
DI 10.3390/ijerph16193570
PG 25
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA JK3MF
UT WOS:000494748600066
PM 31554274
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Jin, H
   Chen, YF
   Wang, BL
   Zhu, Y
   Chen, L
   Han, XQ
   Ma, GS
   Liu, NF
AF Jin, Hong
   Chen, Yifei
   Wang, Bilei
   Zhu, Yi
   Chen, Long
   Han, Xiqiong
   Ma, Genshan
   Liu, Naifeng
TI Association between brain-derived neurotrophic factor and von Willebrand
   factor levels in patients with stable coronary artery disease
SO BMC CARDIOVASCULAR DISORDERS
LA English
DT Article
DE Brain-derived neurotrophic factor; Coronary artery disease; Von
   Willebrand factor; Prognosis
ID ENDOTHELIAL DYSFUNCTION; METABOLIC SYNDROME; OXIDATIVE STRESS;
   HEART-DISEASE; PLASMA-LEVELS; RISK-FACTORS; BDNF; ATHEROSCLEROSIS;
   MARKER; CELLS
AB Background: Brain-derived neurotrophic factor (BDNF) is a neurotrophin involved in angiogenesis and maintenance of endothelial integrity. Whether circulating BDNF levels are associated with von Willebrand factor (vWF) levels, which are indicators of endothelial dysfunction is not known. This study investigated the association between plasma BNDF and vWF levels and whether these biomarkers could predict cardiovascular events at a 12-month follow-up in patients with stable coronary artery disease (CAD).
   Methods: We recruited 234 patients with suspected angina pectoris. Subjects were divided into CAD (n = 143) and control (n = 91) groups based on coronary angiography. Plasma BDNF and vWF levels were measured using ELISA. Patients were followed-up for one year, and information on adverse cardiac events was collected.
   Results: CAD patients exhibited significantly lower plasma BDNF and higher vWF levels than those of control patients. High vWF levels were associated with low BDNF levels even after adjustment for age, gender, low-density lipoprotein (LDL) levels, and the presence of diabetes mellitus. A receiver operating characteristic curve was used to determine whether low BDNF and high vWF levels could predict adverse cardiovascular events. The area under the curve for vWF and the inverse of BDNF were 0.774 and 0.804, respectively.
   Conclusions: These findings suggest that endothelial dysfunction is an important determinant of the impaired circulating BDNF levels, and they further reflected cardiovascular prognosis in stable CAD patients.
C1 [Jin, Hong; Wang, Bilei; Zhu, Yi; Chen, Long; Han, Xiqiong; Ma, Genshan; Liu, Naifeng] Southeast Univ, Zhongda Hosp, Med Sch, Dept Cardiol, Nanjing 210009, Jiangsu, Peoples R China.
   [Chen, Yifei] Wuxi Xishan Peoples Hosp, Dept Cardiol, Wuxi 214000, Jiangsu, Peoples R China.
C3 Southeast University - China
RP Jin, H (corresponding author), Southeast Univ, Zhongda Hosp, Med Sch, Dept Cardiol, Nanjing 210009, Jiangsu, Peoples R China.
EM jinhong5985@163.com
RI Chen, Long/MEP-6001-2025; Chen, Yifei/KIK-7125-2024; Liu,
   Nai-feng/AAM-7836-2020
FU Science and Technology Support, Social Development Research Fund, Health
   Bureau, Jiangsu Province Government [BE2011793]
FX This study was supported by the Science and Technology Support, Social
   Development Research Fund (BE2011793), Health Bureau, Jiangsu Province
   Government. The views and opinions expressed in this paper do not
   necessarily reflect those of the Department of Health.
CR [Anonymous], MEDIATORS INFLAMM
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NR 42
TC 53
Z9 57
U1 0
U2 9
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1471-2261
J9 BMC CARDIOVASC DISOR
JI BMC Cardiovasc. Disord.
PD FEB 6
PY 2018
VL 18
AR 23
DI 10.1186/s12872-018-0762-z
PG 8
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA FU9ZK
UT WOS:000424215500003
PM 29409455
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Jamilian, M
   Samimi, M
   Ebrahimi, FA
   Aghadavod, E
   Mohammadbeigi, R
   Rahimi, M
   Asemi, Z
AF Jamilian, Mehri
   Samimi, Mansooreh
   Ebrahimi, Faraneh Afshar
   Aghadavod, Esmat
   Mohammadbeigi, Robabeh
   Rahimi, Maryam
   Asemi, Zatollah
TI Effects of Selenium Supplementation on Gene Expression Levels of
   Inflammatory Cytokines and Vascular Endothelial Growth Factor in
   Patients with Gestational Diabetes (Publication with Expression of
   Concern)
SO BIOLOGICAL TRACE ELEMENT RESEARCH
LA English
DT Article; Publication with Expression of Concern
DE Selenium; Gene expression; Inflammation; Gestational diabetes
ID NECROSIS-FACTOR-ALPHA; OXIDATIVE STRESS; FACTOR-BETA; METABOLIC
   SYNDROME; ADIPOSE-TISSUES; DOUBLE-BLIND; WOMEN; ACTIVATION; PREGNANCY;
   VASCULOGENESIS
AB Selenium is known to exert multiple beneficial effects including anti-inflammatory actions. The aim of the study was to evaluate the effects of selenium supplementation on gene expression levels of inflammatory cytokines and vascular endothelial growth factor (VEGF) in women with gestational diabetes (GDM). This randomized double-blind, placebo-controlled trial was carried out among 40 subjects diagnosed with GDM aged 18-40 years old. Subjects were randomly allocated into two groups to receive either 200 mu g/day selenium supplements (n = 20) or placebo (n = 20) for 6 weeks. Gene expression of inflammatory cytokines and VEGF were assessed in lymphocytes of GDM women with RT-PCR method. Results of RT-PCR indicated that after the 6-week intervention, compared with the placebo, selenium supplementation downregulated gene expression of tumor necrosis factor alpha (TNF-alpha) (P = 0.02) and transforming growth factor beta (TGF-ss) (P = 0.01), and upregulated gene expression of VEGF (P = 0.03) in lymphocytes of patients with GDM. There was no statistically significant change following supplementation with selenium on gene expression of interleukin (IL)-1 ss and IL-8 in lymphocytes of subjects with GDM. Selenium supplementation for 6 weeks in women with GDM significantly decreased gene expression of TNF-alpha and TGF-ss, and significantly increased gene expression of VEGF, but did not affect gene expression of IL-1 ss and IL-8.
C1 [Jamilian, Mehri] Arak Univ Med Sci, Sch Med, Endocrinol & Metab Res Ctr, Dept Gynecol & Obstet, Arak, Iran.
   [Samimi, Mansooreh; Ebrahimi, Faraneh Afshar] Kashan Univ Med Sci, Sch Med, Dept Gynecol & Obstet, Kashan, Iran.
   [Aghadavod, Esmat; Asemi, Zatollah] Kashan Univ Med Sci, Res Ctr Biochem & Nutr Metab Dis, Kashan, IR, Iran.
   [Mohammadbeigi, Robabeh; Rahimi, Maryam] Iran Univ Med Sci, Sch Med, Dept Gynecol & Obstet, Tehran, Iran.
C3 Iran University of Medical Sciences
RP Asemi, Z (corresponding author), Kashan Univ Med Sci, Res Ctr Biochem & Nutr Metab Dis, Kashan, IR, Iran.; Rahimi, M (corresponding author), Iran Univ Med Sci, Sch Med, Dept Gynecol & Obstet, Tehran, Iran.
EM me616us@yahoo.com; asemi_r@yahoo.com
RI Mohammadbeigi, Robabeh/Y-3248-2019; asemi, zatollah/J-2677-2018;
   jamilian, mehri/F-7559-2016; Ebrahimi, Fatemeh/JEZ-7438-2023; Aghadavod,
   Esmat/I-7736-2017; Asemi, Zatollah/G-7393-2017; Samimi,
   Mansoreh/V-3813-2017
OI Aghadavod, Esmat/0000-0001-9456-9238; Asemi,
   Zatollah/0000-0001-5265-4792; mohammadbeigi,
   robabeh/0000-0001-7489-4594; Samimi, Mansoreh/0000-0002-5809-3612
FU AUMS
FX This study was founded by a grant from the Vice-chancellor for Research,
   AUMS, and Iran.
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NR 53
TC 14
Z9 17
U1 0
U2 19
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0163-4984
EI 1559-0720
J9 BIOL TRACE ELEM RES
JI Biol. Trace Elem. Res.
PD FEB
PY 2018
VL 181
IS 2
BP 199
EP 206
DI 10.1007/s12011-017-1045-8
PG 8
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA FS7WU
UT WOS:000422621100003
PM 28528475
DA 2025-06-11
ER

PT J
AU Castellon, X
   Bogdanova, V
AF Castellon, Xavier
   Bogdanova, Vera
TI Chronic Inflammatory Diseases and Endothelial Dysfunction
SO AGING AND DISEASE
LA English
DT Review
DE endothelial dysfunction; atherosclerosis; inflammatory diseases;
   non-invasive artery age testing methods; FMD
ID ANGIOTENSIN-ALDOSTERONE SYSTEM; INTIMA-MEDIA THICKNESS;
   CORONARY-HEART-DISEASE; VON-WILLEBRAND-FACTOR; C-REACTIVE PROTEIN;
   RISK-FACTORS; SUBCLINICAL ATHEROSCLEROSIS; ANTIPHOSPHOLIPID SYNDROME;
   RESISTANCE ARTERIES; METABOLIC SYNDROME
AB Chronic inflammatory diseases are associated with increases in cardiovascular diseases (CVD) and subclinical atherosclerosis as well as early-stage endothelial dysfunction screening using the FMD method (Flow Mediated Dilation). This phenomenon, referred to as accelerated pathological remodeling of arterial wall, could be attributed to traditional risk factors associated with atherosclerosis. Several new non-invasive techniques have been used to study arterial wall's structural and functional alterations. These techniques (based of Radio Frequency, RF) allow for an assessment of artery age through calculations of intima-media thickness (RF-QIMT), pulse wave rate (RF-QAS) and endothelial dysfunction degree (FMD). The inflammatory and autoimmune diseases should now be considered as new cardiovascular risk factors, result of the major consequences of oxidative stress and RAS (Renin Angiotensin System) imbalance associated with the deleterious effect of known risk factors that lead to the alteration of the arterial wall. Inflammation plays a key role in all stages of the formation of vascular lesions maintained and exacerbated by the risk factors. The consequence of chronic inflammation is endothelial dysfunction that sets in and we can define it as an integrated marker of the damage to arterial walls by classic risk factors. The atherosclerosis, which develops among these patients, is the main cause for cardiovascular morbi-mortality and uncontrolled chronic biological inflammation, which quickly favors endothelial dysfunction. These inflammatory and autoimmune diseases should now be considered as new cardiovascular risk factors.
C1 [Castellon, Xavier; Bogdanova, Vera] Privat Hosp, F-91200 Paris, France.
RP Castellon, X (corresponding author), Privat Hosp, 38 Ave Jules Valles, F-91200 Athis Mons, Athis Mons Pari, France.
EM xavier.castellon@orange.fr
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NR 61
TC 140
Z9 155
U1 0
U2 9
PU INT SOC AGING & DISEASE
PI FORT WORTH
PA EDITORIAL OFF, 3400 CAMP BOWIE BLVD, FORT WORTH, TX 76106 USA
SN 2152-5250
J9 AGING DIS
JI Aging Dis.
PD FEB
PY 2016
VL 7
IS 1
DI 10.14336/AD.2015.0803
PG 9
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA DO5AV
UT WOS:000377796900008
PM 26815098
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Wannamethee, SG
   Whincup, PH
   Shaper, AG
   Lennon, L
   Sattar, N
AF Wannamethee, S. Goya
   Whincup, Peter H.
   Shaper, A. Gerald
   Lennon, Lucy
   Sattar, Naveed
TI γ-Glutamyltransferase, Hepatic Enzymes, and Risk of Incident Heart
   Failure in Older Men
SO ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
LA English
DT Article
DE epidemiology; heart failure; risk factors; hepatic enzymes
ID CARDIOVASCULAR-DISEASE MORTALITY; MIDDLE-AGED MEN;
   MYOCARDIAL-INFARCTION; INSULIN-RESISTANCE; METABOLIC SYNDROME; OXIDATIVE
   STRESS; AUSTRIAN ADULTS; LIVER-ENZYMES; ASSOCIATION; HEALTH
AB Objective-The relationship between gamma-glutamyl transferase (GGT) and heart failure (HF) in older adults is unknown. We have examined the relationship between GGT, other markers of hepatic function (alanine aminotransferase, aspartate transaminase, and alkaline phosphatase), and incident HF in older men.
   Methods and Results-This was a prospective study of 3494 men aged 60 to 79 years with no diagnosed HF or myocardial infarction followed up for a mean period of 9 years, in whom there were 168 incident HF cases. Elevated GGT (top quartile, >= 38 U/L) was associated with significantly increased risk of incident HF in men aged <70 years but not in men aged >= 70 years (test for age-GGT interaction, P < 0.0001). The increased risk of HF associated with elevated GGT persisted after adjustment for a wide range of established and novel risk factors for HF, including diabetes, stroke, obesity, systolic blood pressure, atrial fibrillation, lung function, inflammation (C-reactive protein), endothelial dysfunction (von Willebrand factor), leptin, and N terminal pro brain natriuretic peptide (adjusted hazard ratio [95% CI], 1.91 [1.07, 3.42]). Other liver function markers showed no significant associations with HF after similar adjustments.
   Conclusion-Elevated GGT was associated with increased risk of HF in men aged <70 years. Additional studies are now needed to determine the mechanisms responsible. (Arterioscler Thromb Vasc Biol. 2012; 32:830-835.)
C1 [Wannamethee, S. Goya; Shaper, A. Gerald; Lennon, Lucy] UCL, Sch Med, Dept Primary Care & Populat Hlth, London NW3 2PF, England.
   [Whincup, Peter H.] Univ London, Dept Populat Hlth Sci & Educ, London, England.
   [Sattar, Naveed] Univ Glasgow, Inst Cardiovasc & Med Sci, British Heart Fdn Glasgow Cardiovasc Res Ctr, Glasgow, Lanark, Scotland.
C3 University of London; University College London; UCL Medical School;
   University of London; University of Glasgow
RP Wannamethee, SG (corresponding author), UCL, Sch Med, Dept Primary Care & Populat Hlth, Royal Free Campus,Rowland Hill St, London NW3 2PF, England.
EM g.wannamethee@ucl.ac.uk
RI Sattar, Naveed/AFN-0504-2022; Lennon, Lucy/AFT-1973-2022
OI Lennon, Lucy/0000-0002-1738-1351
FU BHF [RG/08/013/25942, 97012]
FX The British Regional Heart Study is a British Heart Foundation (BHF)
   research group and receives support from BHF Programme Grant
   RG/08/013/25942. The examination of study men aged 60 to 79 years was
   supported by BHF Project Grant 97012.
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U1 0
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1079-5642
EI 1524-4636
J9 ARTERIOSCL THROM VAS
JI Arterioscler. Thromb. Vasc. Biol.
PD MAR
PY 2012
VL 32
IS 3
BP 830
EP 835
DI 10.1161/ATVBAHA.111.240457
PG 6
WC Hematology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Hematology; Cardiovascular System & Cardiology
GA 897HP
UT WOS:000300639300041
PM 22223732
OA Bronze, Green Submitted
DA 2025-06-11
ER

PT J
AU Margioris, AN
AF Margioris, Andrew N.
TI Fatty acids and postprandial inflammation
SO CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE
LA English
DT Article
DE C-reactive protein; postprandial inflammation; n-3 and n-6
   polyunsaturated fatty acids
ID C-REACTIVE PROTEIN; ALPHA-LINOLENIC ACID; FISH-OIL; ENDOTHELIAL
   FUNCTION; METABOLIC SYNDROME; OXIDATIVE STRESS; N-3; MARKERS; LIPIDS;
   RICH
AB Purpose of review
   Postprandial inflammation is an independent factor in evaluating food quality in addition to the well known parameters of nutritional value, caloric content and amount of carbohydrates, fats, proteins, minerals and vitamins. Among the latter, the quality and quantity of fatty acids in a meal is a major determinant of the magnitude of postprandial inflammation. Purpose of this review is to describe this exciting new area of research and its repercussions in the way we, the consumers, and the food industry evaluate the type and quantity of fat in food.
   Recent findings
   A number of, by now classical, epidemiologic studies have documented a strong association between the type of fatty acids consumed and the incidence of cardiovascular diseases. Recently published reports suggest that the adverse effect of dietary fatty acids on cardiovascular health depends on their postprandial modification of innate immunity ending in the so-called 'postprandial metabolic inflammation'.
   Summary
   The quantity of fat and its qualitative characteristics such as the percentage of saturated fatty acids and the ratio of n-3 to n-6 polyunsaturated fatty acids (PUFAs) in a meal have emerged as major determinants of the magnitude of postprandial inflammatory response. In this review, we will summarize all experimental evidence suggesting that the two families of PUFA appear to have antagonistic effects on postprandial inflammation, n-3 PUFA being anti-inflammatory while n-6 PUFA proinflammatory.
C1 Univ Crete, Dept Clin Chem, Sch Med, Iraklion, Greece.
C3 University of Crete
RP Margioris, AN (corresponding author), Univ Crete, Dept Clin Chem, Sch Med, Iraklion, Greece.
EM andym@med.uoc.gr
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NR 49
TC 126
Z9 147
U1 2
U2 23
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1363-1950
EI 1473-6519
J9 CURR OPIN CLIN NUTR
JI Curr. Opin. Clin. Nutr. Metab. Care
PD MAR
PY 2009
VL 12
IS 2
BP 129
EP 137
DI 10.1097/MCO.0b013e3283232a11
PG 9
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 420DK
UT WOS:000264268500005
PM 19202384
DA 2025-06-11
ER

PT J
AU Natali, A
   Toschi, E
   Baldeweg, S
   Ciociaro, D
   Favilla, S
   Saccà, L
   Ferrannini, E
AF Natali, A
   Toschi, E
   Baldeweg, S
   Ciociaro, D
   Favilla, S
   Saccà, L
   Ferrannini, E
TI Clustering of insulin resistance with vascular dysfunction and low-grade
   inflammation in type 2 diabetes
SO DIABETES
LA English
DT Article
ID ENDOTHELIUM-DEPENDENT VASODILATION; CORONARY-HEART-DISEASE; C-REACTIVE
   PROTEIN; METABOLIC SYNDROME; CARDIOVASCULAR-DISEASE; ALL-CAUSE;
   OXIDATIVE STRESS; MORTALITY; OBESITY; HYPERTENSION
AB Vascular dysfunction, low-grade inflammation, insulin resistance, and impaired fibrinolysis have each been reported to be present in type 2 diabetes, but their relationships, and the role of obesity, have not been investigated. We measured insulin sensitivity (euglycemic clamp), forearm blood flow responses to graded local acetylcholine (Ach) and sodium nitroprusside (SNP) infusions, plasma concentrations of tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, von Willebrand factor (vWF), plasminogen activator inhibitor (PAI)-1, tissue plasminogen activator (tPA), and high-sensitivity C-reactive protein (hs-CRP) in 81 diabetic patients. When patients were stratified by insulin resistance, more severe insulin resistance was associated (P < 0.05) with overweight, central fat distribution, hypertension, and dyslipidemia (with similar sex distribution, age, fasting plasma glucose, and HbA(1c)). With regard to vascular function, both endothelium-dependent (Ach) (-22, -40, and -52%; P < 0.0001) and -independent (SNP) (-3, - 7, and -27%; P < 0.02) vasodilatation were progressively reduced across insulin resistance tertiles. In multivariate analysis, inflammatory markers (IL-6, bs-CRP, and TNF-alpha) were independently associated with insulin resistance and fasting glycemia, fibrinolytic markers PAI-1 and tPA with insulin resistance and central fat distribution, and vascular indexes (vWF, Ach, and SNP vasodilation) with insulin resistance and obesity or cytokines (TNF-alpha or IL-6). In type 2 diabetes, insulin resistance is associated with vascular dysfunction/damage, impaired fibrinolysis, and low-grade inflammation independently of obesity and poor glycemic contirol.
C1 Univ Pisa, Dept Internal Med, I-56100 Pisa, Italy.
   Univ Pisa, CNR, Inst Clin Physiol, I-56100 Pisa, Italy.
   UCL, Dept Med, London, England.
   Univ Naples Federico II, Dept Internal Med & Cardiovasc Sci, Naples, Italy.
C3 University of Pisa; University of Pisa; Consiglio Nazionale delle
   Ricerche (CNR); Istituto di Fisiologia Clinica (IFC-CNR); University of
   London; University College London; University of Naples Federico II
RP Univ Pisa, Dept Internal Med, Via Roma,67, I-56100 Pisa, Italy.
EM anatali@ifc.cnr.it
RI Natali, Andrea/N-5535-2015
OI Natali, Andrea/0000-0002-8465-7717; Baldeweg, Stephanie
   E/0000-0002-8381-1612; Ciociaro, Demetrio/0009-0001-4701-0586
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NR 51
TC 154
Z9 174
U1 0
U2 9
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0012-1797
EI 1939-327X
J9 DIABETES
JI Diabetes
PD APR
PY 2006
VL 55
IS 4
BP 1133
EP 1140
DI 10.2337/diabetes.55.04.06.db05-1076
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 028MK
UT WOS:000236491400035
PM 16567539
OA Bronze
DA 2025-06-11
ER

PT J
AU Liao, YL
   Takashima, S
   Maeda, N
   Ouchi, N
   Komamura, K
   Shimomura, I
   Hori, M
   Matsuzawa, Y
   Funahashi, T
   Kitakaze, M
AF Liao, YL
   Takashima, S
   Maeda, N
   Ouchi, N
   Komamura, K
   Shimomura, I
   Hori, M
   Matsuzawa, Y
   Funahashi, T
   Kitakaze, M
TI Exacerbation of heart failure in adiponectin-deficient mice due to
   impaired regulation of AMPK and glucose metabolism
SO CARDIOVASCULAR RESEARCH
LA English
DT Article
DE adiponectin; heart failure; myocardial hypertrophy; metabolic syndrome
ID INSULIN-RESISTANCE; CARDIAC-HYPERTROPHY; CARDIOVASCULAR-DISEASE;
   PROTEIN; MORTALITY; PREVENTS; IMPACT; GENE; INHIBITION; EXPRESSION
AB Objective: Insulin resistance (IR) was reported to be associated with chronic heart failure (CHF). Adiponectin, an insulin-sensitizing hormone with anti-inflammatory activity, improves energy metabolism via AMP-activated protein kinase (AMPK). AMPK deficiency is associated with depressed cardiac function under stress conditions. However, it is not clear whether adiponectin plays an important role in CHF. We hypothesize that deficiency of adiponectin might result in deterioration of heart failure.
   Methods: Using adiponectin null mice and their littermates, we examined the effects of adiponectin on LV pressure overload-induced cardiac hypertrophy and failure, and investigated the mechanisms involved.
   Results: Three weeks after transverse aortic constriction (TAC), cardiac hypertrophy (evaluated from the heart-to-body weight ratio: 7.62 +/- 0.27 in wild-type (WT) mice, 9.97 +/- 1.13 in knockout (KO) mice, P < 0.05) and pulmonary congestion (lung-to-body weight ratio: 9.05 +/- 1.49 in WT mice, 14.95 +/- 2.36 in KO mice, P < 0.05) were significantly greater in adiponectin KO mice than WT mice. LV dimensions were also increased in KO mice. Compared with WT TAC mice, expression of AMPKot protein was lower, while IR was higher in KO TAC mice.
   Conclusion: These findings indicate that adiponectin deficiency leads to progressive cardiac remodeling in pressure overloaded condition mediated via lowing AMPK signaling and impaired glucose metabolism. (c) 2005 European Society of Cardiology. Published by Elsevier B.V. All rights reserved.
C1 Natl Cardiovasc Ctr, Div Cardiovasc Med, Suita, Osaka 5658565, Japan.
   Osaka Univ, Grad Sch Med, Dept Internal Med & Therapeut, Suita, Osaka 5650871, Japan.
   Osaka Univ, Grad Sch Med, Dept Internal Med & Mol Sci, Suita, Osaka 5650871, Japan.
C3 National Cerebral & Cardiovascular Center - Japan; The University of
   Osaka; The University of Osaka
RP Natl Cardiovasc Ctr, Div Cardiovasc Med, 5-7-1 Fujishirodai, Suita, Osaka 5658565, Japan.
EM kitakaze@zf6.so-net.ne.jp
RI Maeda, Norikazu/LZI-4561-2025; OUCHI, Noriyuki/I-7306-2014; Liao,
   Yulin/AAP-6315-2021
OI Liao, yulin/0000-0001-5961-390X
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NR 44
TC 187
Z9 222
U1 0
U2 10
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0008-6363
EI 1755-3245
J9 CARDIOVASC RES
JI Cardiovasc. Res.
PD SEP 1
PY 2005
VL 67
IS 4
BP 705
EP 713
DI 10.1016/j.cardiores.2005.04.018
PG 9
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 954VO
UT WOS:000231183500017
PM 15907819
DA 2025-06-11
ER

PT J
AU Alsaleem, MA
   Al-Kuraishy, HM
   Al-Gareeb, AI
   Abdel-Fattah, MM
   Alrouji, M
   Al-Harchan, NA
   Alruwaili, M
   Papadakis, M
   Alexiou, A
   Batiha, GE
AF Alsaleem, Mansour A.
   Al-Kuraishy, Hayder M.
   Al-Gareeb, Ali I.
   Abdel-Fattah, Maha M.
   Alrouji, Mohammed
   Al-Harchan, Nasser A.
   Alruwaili, Mubarak
   Papadakis, Marios
   Alexiou, Athanasios
   Batiha, Gaber El-Saber
TI Decrypting the Possible Mechanistic Role of Fenofibrate in Alzheimer's
   Disease and Type 2 Diabetes: The Truth and Mystery
SO JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
LA English
DT Review
DE Alzheimer's disease; fenofibrate; T2D
ID PPAR-ALPHA AGONIST; NICOTINIC ACETYLCHOLINE-RECEPTOR; GROWTH-FACTOR 21;
   MILD COGNITIVE IMPAIRMENT; ISLET AMYLOID POLYPEPTIDE; NF-KAPPA-B;
   NEUROTROPHIC FACTOR; INSULIN-RESISTANCE; OXIDATIVE STRESS; METABOLIC
   SYNDROME
AB Alzheimer's disease (AD) is a neurodegenerative disease caused by the progressive deposition of extracellular amyloid beta (A beta) and intracellular neurofibrillary tangles (NFTs). Of note, metabolic disorders such as insulin resistance (IR) and type 2 diabetes (T2D) are associated with the development of brain IR and associated neurodegeneration. In addition, AD neuropathology and linked cognitive impairment accelerate the development of peripheral IR and the progression of T2D. Therefore, there is a bidirectional relationship between T2D and AD. It has been demonstrated that AD and T2D induce dysregulation of peroxisome proliferator-activated receptor alpha (PPAR-alpha) leading to the central and peripheral metabolic disturbances. Hence, dysregulated PPAR-alpha could be a shared mechanism in both AD and T2D, and restoration of PPAR-alpha signalling by PPAR-alpha agonist fenofibrate (FN) may alleviate T2D and AD. Therefore, this review aims to shed light on the potential involvement of PPAR-alpha in T2D and AD, and how FN could be effective in the management of AD. FN seems to be effective in both AD and T2D by dual neuroprotective and antidiabetic effects that can mitigate AD neuropathology and T2D-related complications by modulating various cellular processes and inflammatory signalling pathways. In conclusion, FN could be a possible candidate in the management of AD and T2D by modulating different signalling pathways involved in the pathogenesis of these conditions.
C1 [Alsaleem, Mansour A.] Qassim Univ, Appl Coll, Unit Sci Res, Buraydah, Saudi Arabia.
   [Al-Kuraishy, Hayder M.] Mustansiriyah Univ, Coll Med, Dept Clin Pharmacol & Med, Baghdad, Iraq.
   [Al-Gareeb, Ali I.] Jabir Ibn Hayyan Med Univ, Radiol Dept, Kufa, Najaf, Iraq.
   [Abdel-Fattah, Maha M.] Beni Suef Univ, Dept Pharmacol & Toxicol, Fac Pharm, Bani Suwayf, Egypt.
   [Alrouji, Mohammed] Shaqra Univ, Coll Appl Med Sci, Dept Clin Lab Sci, Shaqra, Saudi Arabia.
   [Al-Harchan, Nasser A.] Al Rasheed Univ, Coll Dent, Dept Clin Pharmacol, Baghdad, Iraq.
   [Alruwaili, Mubarak] Jouf Univ, Coll Med, Dept Internal Med, Sakaka, Saudi Arabia.
   [Papadakis, Marios] UNIV WITTEN HERDECKE, Univ Hosp Witten Herdecke, WITTEN, Germany.
   [Alexiou, Athanasios] Chandigarh Univ, Univ Ctr Res & Dev, Mohali, India.
   [Alexiou, Athanasios] Novel Global Community Educ Fdn, Dept Sci & Engn, Sydney, NSW, Australia.
   [Alexiou, Athanasios] Funogen, Dept Res & Dev, Athens 11741, Greece.
   [Batiha, Gaber El-Saber] Damanhour Univ, Fac Vet Med, Dept Pharmacol & Therapeut, Damanhour 22511, AlBeheira, Egypt.
C3 Qassim University; Mustansiriya University; Jabir Ibn Hayyan University
   for Medical & Pharmaceutical Sciences; Egyptian Knowledge Bank (EKB);
   Beni Suef University; Shaqra University; Al Jouf University; Witten
   Herdecke University; Chandigarh University; Egyptian Knowledge Bank
   (EKB); Damanhour University
RP Abdel-Fattah, MM (corresponding author), Beni Suef Univ, Dept Pharmacol & Toxicol, Fac Pharm, Bani Suwayf, Egypt.; Alrouji, M (corresponding author), Shaqra Univ, Coll Appl Med Sci, Dept Clin Lab Sci, Shaqra, Saudi Arabia.; Papadakis, M (corresponding author), UNIV WITTEN HERDECKE, Univ Hosp Witten Herdecke, WITTEN, Germany.; Batiha, GE (corresponding author), Damanhour Univ, Fac Vet Med, Dept Pharmacol & Therapeut, Damanhour 22511, AlBeheira, Egypt.
EM mahamohammed@pharm.bsu.edu.eg; malrouji@su.edu.sa;
   drmariospapadakis@gmail.com; gaberbatiha@gmail.com
RI Al-gareeb, Ali/AHD-4577-2022; Alrouji, Mohammed/GXM-8835-2022;
   al-kuraishy, hayder/AAE-6673-2019; Abdel-Fattah, Maha/HHS-2044-2022;
   Papadakis, Marios/AAI-6622-2020; Alexiou, Athanasios/AAT-8491-2021
OI Papadakis, Marios/0000-0002-9020-874X; mohammed,
   maha/0000-0002-9019-8932
FU The University of Witten-Herdecke Germany; Deanship of Scientific
   Research at Shaqra University
FX The authors would like to thank the Deanship of Scientific Research at
   Shaqra University for supporting this work. This work was made Open
   Access with funding enabled and organised by Projekt DEAL.
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NR 257
TC 0
Z9 0
U1 2
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1582-1838
EI 1582-4934
J9 J CELL MOL MED
JI J. Cell. Mol. Med.
PD MAR
PY 2025
VL 29
IS 5
AR e70378
DI 10.1111/jcmm.70378
PG 20
WC Cell Biology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Research & Experimental Medicine
GA Z3L0Q
UT WOS:001437953900001
PM 40040308
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Sato, F
   Bhawal, UK
   Oikawa, K
   Muragaki, Y
AF Sato, Fuyuki
   Bhawal, Ujjal K.
   Oikawa, Kosuke
   Muragaki, Yasuteru
TI Loss of Dec1 inhibits alcohol-induced hepatic lipid accumulation
   and circadian rhythm disorder
SO BMC MOLECULAR AND CELL BIOLOGY
LA English
DT Article
DE Dec1; Alcohol; Immunohistochemistry; AMPK; PPARs
ID ACTIVATED PROTEIN-KINASE; METABOLIC SYNDROME; GENE-EXPRESSION; FATTY
   LIVER; ETHANOL; MICE
AB Chronic alcohol exposure increases liver damage such as lipid accumulation and hepatitis, resulting in hepatic cirrhosis. Chronic alcohol intake is known to disturb circadian rhythms in humans and animals. DEC1, a basic helix-loop-helix transcription factor, plays an important role in the circadian rhythm, inflammation, immune responses, and tumor progression. We have previously shown that Dec1 deficiency inhibits stresses such as periodontal inflammation and perivascular fibrosis of the heart. However, the significance of Dec1 deficiency in chronic alcohol consumption remains unclear. In the present study, we investigated whether the biological stress caused by chronic alcohol intake is inhibited in Dec1 knockout mice. We treated control and Dec1 knockout mice for three months by providing free access to 10% alcohol. The Dec1 knockout mice consumed more alcohol than control mice, however, we observed severe hepatic lipid accumulation and circadian rhythm disturbance in control mice. In contrast, Dec1 knockout mice exhibited little effect on these outcomes. We also investigated the expression of peroxisome proliferator-activated receptors (PPARs) and AMP-activated protein kinase (AMPK), which are involved in the regulation of fatty acid metabolism. Immunohistochemical analysis revealed increases of phosphorylation AMPK and PPARa but decreases PPARg in Dec1 knockout mice compared to that in control mice. This indicates a molecular basis for the inhibition of hepatic lipid accumulation in alcohol-treated Dec1 knockout mice. These results suggest a novel function of Dec1 in alcohol-induced hepatic lipid accumulation and circadian rhythm disorders.
C1 [Sato, Fuyuki] Shizuoka Canc Ctr, Dept Diagnost Pathol, Shizuoka 4118777, Japan.
   [Sato, Fuyuki; Oikawa, Kosuke; Muragaki, Yasuteru] Wakayama Med Univ, Sch Med, Dept Pathol, Wakayama 6418509, Japan.
   [Bhawal, Ujjal K.] Nihon Univ, Res Inst Oral Sci, Sch Dent Matsudo, Chiba 2718587, Japan.
   [Bhawal, Ujjal K.] Saveetha Univ, Saveetha Med Coll & Hosp, Saveetha Inst Med & Tech Sci, Ctr Global Hlth Res, Chennai 600077, India.
C3 Shizuoka Cancer Center; Wakayama Medical University; Nihon University;
   Saveetha Institute of Medical & Technical Science; Saveetha Medical
   College & Hospital
RP Sato, F (corresponding author), Shizuoka Canc Ctr, Dept Diagnost Pathol, Shizuoka 4118777, Japan.; Sato, F (corresponding author), Wakayama Med Univ, Sch Med, Dept Pathol, Wakayama 6418509, Japan.
EM fsatoDEC1DEC2@yahoo.co.jp
RI Oikawa, Kosuke/LUZ-1257-2024
OI Sato, Fuyuki/0000-0002-4435-2118
FU JSPS KAKENHI [16K09624]
FX This study was supported by JSPS KAKENHI (grant number 16K09624).
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NR 36
TC 2
Z9 2
U1 0
U2 3
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 2661-8850
J9 BMC MOL CELL BIOL
JI BMC Mol. Cell Biol.
PD JAN 2
PY 2024
VL 25
IS 1
AR 1
DI 10.1186/s12860-023-00497-y
PG 7
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA DX0Z3
UT WOS:001135276300001
PM 38166556
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Kulesza, T
   Typiak, M
   Rachubik, P
   Rogacka, D
   Audzeyenka, I
   Saleem, MA
   Piwkowska, A
AF Kulesza, Tomasz
   Typiak, Marlena
   Rachubik, Patrycja
   Rogacka, Dorota
   Audzeyenka, Irena
   Saleem, Moin A.
   Piwkowska, Agnieszka
TI Pit 1 transporter (SLC20A1) as a key factor in the NPP1-mediated
   inhibition of insulin signaling in human podocytes
SO JOURNAL OF CELLULAR PHYSIOLOGY
LA English
DT Article
DE diabetic nephropathy; insulin resistance; insulin signaling; phosphate
   transporters; podocyte
ID RECEPTOR-MEDIATED ENDOCYTOSIS; MEMBRANE GLYCOPROTEIN PC-1;
   DIABETIC-NEPHROPATHY; OXIDATIVE STRESS; RESISTANCE; EXPRESSION; INJURY;
   SUPPRESSION; DISEASE; OXIDASE
AB Podocytes are crucially involved in blood filtration in the glomerulus. Their proper function relies on efficient insulin responsiveness. The insulin resistance of podocytes, defined as a reduction of cell sensitivity to this hormone, is the earliest pathomechanism of microalbuminuria that is observed in metabolic syndrome and diabetic nephropathy. In many tissues, this alteration is mediated by the phosphate homeostasis-controlling enzyme nucleotide pyrophosphatase/phosphodiesterase 1 (NPP1). By binding to the insulin receptor (IR), NPP1 inhibits downstream cellular signaling. Our previous research found that hyperglycemic conditions affect another protein that is involved in phosphate balance, type III sodium-dependent phosphate transporter 1 (Pit 1). In the present study, we evaluated the insulin resistance of podocytes after 24 h of incubation under hyperinsulinemic conditions. Thereafter, insulin signaling was inhibited. The formation of NPP1/IR complexes was observed at that time. A novel finding in the present study was our observation of an interaction between NPP1 and Pit 1 after the 24 h stimulation of podocytes with insulin. After downregulation of the SLC20A1 gene, which encodes Pit 1, we established insulin resistance in podocytes that were cultured under native conditions, manifested as a lack of intracellular insulin signaling and the inhibition of glucose uptake via the glucose transporter type 4. These findings suggest that Pit 1 might be a major factor that participates in the NPP1-mediated inhibition of insulin signaling.
C1 [Kulesza, Tomasz; Typiak, Marlena; Rachubik, Patrycja; Rogacka, Dorota; Audzeyenka, Irena; Piwkowska, Agnieszka] Polish Acad Sci, Mossakowski Med Res Inst, Lab Mol & Cellular Nephrol, Wita Stwosza St 63, PL-80308 Gdansk, Poland.
   [Typiak, Marlena] Univ Gdansk, Fac Biol, Dept Gen & Med Biochem, Gdansk, Poland.
   [Rogacka, Dorota; Audzeyenka, Irena; Piwkowska, Agnieszka] Univ Gdansk, Fac Chem, Dept Mol Biotechnol, Gdansk, Poland.
   [Saleem, Moin A.] Univ Bristol, Bristol Renal, Bristol, England.
C3 Polish Academy of Sciences; Mossakowski Medical Research Institute of
   the Polish Academy of Sciences; Fahrenheit Universities; University of
   Gdansk; Fahrenheit Universities; University of Gdansk; University of
   Bristol
RP Kulesza, T (corresponding author), Polish Acad Sci, Mossakowski Med Res Inst, Lab Mol & Cellular Nephrol, Wita Stwosza St 63, PL-80308 Gdansk, Poland.
EM tkulesza@imdik.pan.pl
RI Piwkowska, Agnieszka/IZD-8242-2023; Audzeyenka, Irena/AAU-9043-2021;
   Typiak, Marlena/ABG-9726-2020; Kulesza, Tomasz/MZQ-7730-2025; Rogacka,
   Dorota Sylwia/AEV-3765-2022
OI Rachubik, Patrycja/0000-0002-7691-8243; Piwkowska,
   Agnieszka/0000-0002-0086-7777; Saleem, Moin/0000-0002-9808-4518;
   Rogacka, Dorota Sylwia/0000-0001-6242-0324; Kulesza,
   Tomasz/0000-0001-5166-7444
FU National Science Center in Poland [2018/29/B/NZ4/02074]
FX ACKNOWLEDGMENTS This study was supported by grant 2018/29/B/NZ4/02074 to
   Agnieszka Piwkowska from the National Science Center in Poland.
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NR 51
TC 2
Z9 2
U1 4
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0021-9541
EI 1097-4652
J9 J CELL PHYSIOL
JI J. Cell. Physiol.
PD AUG
PY 2023
VL 238
IS 8
BP 1921
EP 1936
DI 10.1002/jcp.31051
EA JUN 2023
PG 16
WC Cell Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Physiology
GA FO9Z6
UT WOS:000998815100001
PM 37269459
DA 2025-06-11
ER

PT J
AU do Bonfim, THF
   Tavares, RL
   de Vasconcelos, MHA
   Gouveia, M
   Nunes, PC
   Soares, NL
   Alves, RC
   de Carvalho, JLP
   Alves, AF
   Pereira, RD
   Cardoso, GA
   Silva, AS
   Aquino, JD
AF Figueiredo do Bonfim, Thais Helena
   Tavares, Renata Leite
   Araujo de Vasconcelos, Maria Helena
   Gouveia, Mirela
   Nunes, Polyana Campos
   Soares, Nais Lira
   Alves, Raquel Coutinho
   Pinto de Carvalho, Jader Luciano
   Alves, Adriano Francisco
   Pereira, Ramon de Alencar
   Cardoso, Glebia Alexa
   Silva, Alexandre Sergio
   Aquino, Jailane de Souza
TI Potentially obesogenic diets alter metabolic and neurobehavioural
   parameters in Wistar rats: a comparison between two dietary models
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Animal model; Cafeteria diet; Metabolic syndrome; Obesity; Western diet
ID HIGH-FAT DIET; ADIPOSE-TISSUE INFLAMMATION; CAFETERIA DIET; OXIDATIVE
   STRESS; WESTERN-DIET; EMOTIONAL BEHAVIOR; INSULIN-RESISTANCE; OBESITY;
   LIVER; TERM
AB Background: Clinical studies related to the obesity pandemic have intensified in recent years, being the animal studies are also considered of great relevance. However, despite the fact that many diets have been reported in the literature to induce obesity in animal models, there is still a gap regarding evidence of the efficacy of these models, considering not only changes in somatic parameters, but also the triggering of comorbidities associated with obesity. In this scenario, the aim of this study was to compare the effectiveness of western and cafeteria diets as obesity-inducing protocols, focusing on the evaluation of metabolic, somatic, oxidative, histological and behavioural parameters of Wistar rats.
   Methods: The rats were fed a control (CON), western (WTD) or cafeteria (CAF) diet for 16 weeks.
   Results: The CAF diet caused anxiogenic-like behaviour. Body mass (BMI), Lee and adiposity indices increased in the CAF group. CAF and WTD diets reduced glucose and insulin tolerance, caused dyslipidemia, increased lipid peroxidation and decrease antioxidant capacity in the liver, kidneys and brain. The WTD and CAF groups shows greater IL-6 protein expression in adipose tissue, developed hepatic steatosis and ischaemic neurons, whereas interstitial nephritis was observed only in the CAF group.
   Conclusion: The CAF diet was most effective in inducing obesity, as shown both by the somatic parameters and by the greater number of obesity-related metabolic and neurobehavioural disorders in the evaluated rats.
C1 [Figueiredo do Bonfim, Thais Helena; Tavares, Renata Leite; Araujo de Vasconcelos, Maria Helena; Gouveia, Mirela; Nunes, Polyana Campos; Soares, Nais Lira; Alves, Raquel Coutinho; Pinto de Carvalho, Jader Luciano; Aquino, Jailane de Souza] Fed Univ Paraiba UFPB, Lab Expt Nutr, Dept Nutr, Joao Pessoa, Paraiba, Brazil.
   [Alves, Adriano Francisco] Fed Univ Paraiba UFPB, Lab Pathol, Dept Physiol & Pathol, Joao Pessoa, Paraiba, Brazil.
   [Pereira, Ramon de Alencar] Fed Univ Minas Gerais UFMG, Dept Pathol, Lab Pathol, Belo Horizonte, MG, Brazil.
   [Cardoso, Glebia Alexa] Univ Fed Paraiba, Associate Grad Program Phys Educ UPE UFPB, Dept Phys Educ, Joao Pessoa, Paraiba, Brazil.
   [Cardoso, Glebia Alexa; Silva, Alexandre Sergio] Fed Univ Paraiba UFPB, Dept Phys Educ, Lab Phys Training Appl Performance & Hlth, Joao Pessoa, Paraiba, Brazil.
C3 Universidade Federal da Paraiba; Universidade Federal da Paraiba;
   Universidade Federal de Minas Gerais; Universidade Federal da Paraiba;
   Universidade Federal da Paraiba
RP Aquino, JD (corresponding author), Univ Fed Paraiba, UFPB, Lab Nutr Expt, Dept Nutr, Cidade Univ S-N, BR-58051900 Joao Pessoa, Paraiba, Brazil.
EM aquinojailane@gmail.com
RI Silva, Alexandre/N-8883-2014
OI de Souza Aquino, Jailane/0000-0002-7221-9867; Soares,
   Nais/0000-0003-2458-9449; Alves, Adriano/0000-0003-2038-1894
FU Coordination for the Improvement of Higher Education Personnel
   (Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior-CAPES,
   Brazil) [0001]
FX The authors thank the Coordination for the Improvement of Higher
   Education Personnel (Coordenacao de Aperfeicoamento de Pessoal de Nivel
   Superior-CAPES, Brazil, grant number 0001) for a scholarship awarded to
   T. H. F. Bonfim, M.H.A de Vasconcelos, M. Gouveia and N.L. Soares
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NR 83
TC 19
Z9 19
U1 0
U2 7
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD JAN 15
PY 2021
VL 279
BP 451
EP 461
DI 10.1016/j.jad.2020.10.034
PG 11
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA PH8SC
UT WOS:000600674200013
PM 33120246
DA 2025-06-11
ER

PT J
AU Cordner, ZA
   Khambadkone, SG
   Boersma, GJ
   Song, L
   Summers, TN
   Moran, TH
   Tamashiro, KLK
AF Cordner, Zachary A.
   Khambadkone, Seva G.
   Boersma, Gretha J.
   Song, Lin
   Summers, Tyler N.
   Moran, Timothy H.
   Tamashiro, Kellie L. K.
TI Maternal high-fat diet results in cognitive impairment and hippocampal
   gene expression changes in rat offspring
SO EXPERIMENTAL NEUROLOGY
LA English
DT Article
DE Maternal diet; Cognition; Insulin; Leptin; Developmental origins of
   health and disease
ID BRAIN MITOCHONDRIAL-FUNCTION; MESSENGER-RNA EXPRESSION; LONG-TERM
   POTENTIATION; INSULIN-RESISTANCE; INDUCED OBESITY; INTRANASAL INSULIN;
   MILK-COMPOSITION; PRENATAL STRESS; ENERGY-BALANCE; SPATIAL MEMORY
AB Consumption of a high-fat diet has long been known to increase risk for obesity, diabetes, and the metabolic syndrome. Further evidence strongly suggests that these same metabolic disorders are associated with an increased risk of cognitive impairment later in life. Now faced with an expanding global burden of obesity and increasing prevalence of dementia due to an aging population, understanding the effects of high-fat diet consumption on cognition is of increasingly critical importance. Further, the developmental origins of many adult onset neuropsychiatric disorders have become increasingly clear, indicating a need to investigate effects of various risk factors, including diet, across the lifespan. Here, we use a rat model to assess the effects of maternal diet during pregnancy and lactation on cognition and hippocampal gene expression of offspring. Behaviorally, adult male offspring of high-fat fed dams had impaired object recognition memory and impaired spatial memory compared to offspring of chow-fed dams. In hippocampus, we found decreased expression of Insr, Lepr, and Slc2a1 (GLUT1) among offspring of high-fat fed dams at postnatal day 21. The decreased expression of Insr and Lepr persisted at postnatal day 150. Together, these data provide additional evidence to suggest that maternal exposure to high-fat diet during pregnancy and lactation can have lasting effects on the brain, behavior, and cognition on adult offspring.
C1 [Cordner, Zachary A.; Khambadkone, Seva G.; Boersma, Gretha J.; Song, Lin; Summers, Tyler N.; Moran, Timothy H.; Tamashiro, Kellie L. K.] Johns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, 720 Rutland Ave,Ross 618, Baltimore, MD 21205 USA.
   [Khambadkone, Seva G.; Moran, Timothy H.; Tamashiro, Kellie L. K.] Johns Hopkins Univ, Sch Med, Cellular & Mol Med Grad Program, 720 Rutland Ave,Ross 618, Baltimore, MD 21205 USA.
   [Boersma, Gretha J.] GGZ Drenthe Mental Hlth Inst, Dept Forens Psychiat, Assen, Netherlands.
   [Song, Lin] Xi An Jiao Tong Univ, Dept Physiol & Pathophysiol, Sch Med, Xian 710061, Shaanxi, Peoples R China.
C3 Johns Hopkins University; Johns Hopkins University; Xi'an Jiaotong
   University
RP Tamashiro, KLK (corresponding author), Johns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, 720 Rutland Ave,Ross 618, Baltimore, MD 21205 USA.
EM ktamashiro@jhmi.edu
RI Song, Lin/AAC-6393-2022
OI Tamashiro, Kellie/0000-0002-9398-8796; Cordner,
   Zachary/0000-0001-6000-567X; Khambadkone, Seva/0000-0003-0900-8917
FU Greif Family Scholar Fund; NIH [HD093338, MH108944]; Dalio
   Philanthropies
FX The authors thank Leonard Marque for his excellent technical support.
   The studies in this manuscript were supported by the Greif Family
   Scholar Fund (Z. A. Cordner), NIH HD093338 (S. G. Khambadkone), NIH
   MH108944 (K. L. Tamashiro), and Dalio Philanthropies.
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NR 128
TC 57
Z9 64
U1 0
U2 32
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0014-4886
EI 1090-2430
J9 EXP NEUROL
JI Exp. Neurol.
PD AUG
PY 2019
VL 318
BP 92
EP 100
DI 10.1016/j.expneurol.2019.04.018
PG 9
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA IG1MA
UT WOS:000473554500010
PM 31051155
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Bhat, ZF
   Morton, JD
   Mason, S
   Bekhit, AEA
   Bhat, HF
AF Bhat, Zuhaib F.
   Morton, James D.
   Mason, Sue
   Bekhit, Alaa El-Din A.
   Bhat, Hina Fayaz
TI Obesity and neurological disorders: Dietary perspective of a global
   menace
SO CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
LA English
DT Review
DE Obesity; co-morbidities; neurological disorders; management; dietary
   aspects
ID VITRO STARCH DIGESTIBILITY; LOW-GLYCEMIC INDEX; OAT BETA-GLUCAN; FREE
   RICE COOKIES; OXIDATIVE STRESS; HEALTHY-SUBJECTS; WHEAT BREAD;
   PHYSICOCHEMICAL PROPERTIES; ALZHEIMERS-DISEASE; METABOLIC SYNDROME
AB Obesity is considered a major public health concern throughout the world among children, adolescents, as well as adults and several therapeutic, preventive and dietary interventions are available. In addition to life style changes and medical interventions, significant milestones have been achieved in the past decades in the development of several functional foods and dietary regimens to reduce this menace. Being a multifactorial phenomenon and related to increased fat mass that adversely affects health, obesity has been associated with the development of several other co-morbidities. A great body of research and strong scientific evidence identifies obesity as an important risk factor for onset and progression of several neurological disorders. Obesity induced dyslipidaemia, metabolic dysfunction, and inflammation are attributable to the development of a variety of effects on central nervous system (CNS). Evidence suggests that neurological diseases such as Parkinson's disease and Alzheimer's disease could be initiated by various metabolic changes, related to CNS damage, caused by obesity. These metabolic changes could alter the synaptic plasticity of the neurons and lead to neural death, affecting the normal physiology of CNS. Dietary intervention in combination with exercise can affect the molecular events involved in energy metabolism and synaptic plasticity and are considered effective non-invasive strategy to counteract cognitive and neurological disorders. The present review gives an overview of the obesity and related neurological disorders and the possible dietary interventions.
C1 [Bhat, Zuhaib F.; Morton, James D.; Mason, Sue] Lincoln Univ, Fac Agr & Life Sci, Wine Food & Mol Biosci, Canterbury, New Zealand.
   [Bekhit, Alaa El-Din A.] Univ Otago, Dunedin, New Zealand.
   [Bhat, Hina Fayaz] Sher E Kashmir Univ Agr Sci & Technol Kashmir, Srinagar, Jammu & Kashmir, India.
C3 Lincoln University - New Zealand; University of Otago; Sher-e-Kashmir
   University of Agricultural Sciences & Technology of Kashmir (SKUAST
   Kashmir)
RP Bhat, ZF; Morton, JD; Mason, S (corresponding author), Lincoln Univ, Fac Agr & Life Sci, Wine Food & Mol Biosci, Canterbury, New Zealand.; Bekhit, AEA (corresponding author), Univ Otago, Dunedin, New Zealand.; Bhat, HF (corresponding author), Sher E Kashmir Univ Agr Sci & Technol Kashmir, Srinagar, Jammu & Kashmir, India.
EM Zuhaib.Bhat@lincolnuni.ac.nz; James.Morton@lincolnuni.ac.nz;
   aladin.bekhit@otago.ac.nz; bhat.hina@rediffmail.com
RI Bekhit, Alaa El-Din/A-4241-2019; Morton, James/C-6149-2012
OI bhat, Dr. Hina/0000-0002-0031-251X
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NR 167
TC 45
Z9 46
U1 2
U2 28
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1040-8398
EI 1549-7852
J9 CRIT REV FOOD SCI
JI Crit. Rev. Food Sci. Nutr.
PD APR 28
PY 2019
VL 59
IS 8
BP 1294
EP 1310
DI 10.1080/10408398.2017.1404442
PG 17
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA HY4AG
UT WOS:000468068600008
PM 29257910
DA 2025-06-11
ER

PT J
AU Wadhwani, N
   Patil, V
   Joshi, S
AF Wadhwani, Nisha
   Patil, Vidya
   Joshi, Sadhana
TI Maternal long chain polyunsaturated fatty acid status and pregnancy
   complications
SO PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
LA English
DT Article
DE DOHaD; Gestational diabetes mellitus; Intrauterine growth restriction;
   LCPUFA; Pregnancy; Preeclampsia; Pregnancy outcome
ID INTRAUTERINE GROWTH RESTRICTION; GESTATIONAL DIABETES-MELLITUS;
   ALPHA-LINOLENIC ACID; DOCOSAHEXAENOIC ACID; FETAL-GROWTH; DEVELOPMENTAL
   ORIGINS; ERYTHROCYTE OMEGA-3; METABOLIC SYNDROME; OXIDATIVE STRESS;
   CARDIOVASCULAR-DISEASE
AB Maternal nutrition plays a crucial role in influencing fetal growth and birth outcome. Any nutritional insult starting several weeks before pregnancy and during critical periods of gestation is known to influence fetal development and increase the risk for diseases during later life. Literature suggests that chronic adult diseases may have their origin during early life - a concept referred to as Developmental Origins of Health and Disease (DOHaD) which states that adverse exposures early in life "program" risks for later chronic disorders. Long chain polyunsaturated fatty acids (LCPUFA), mainly omega-6 and omega-3 fatty acids are known to have an effect on fetal programming. The placental supply of optimal levels of LCPUFA to the fetus during early life is extremely important for the normal growth and development of both placenta and fetus. Any alteration in placental development will result in adverse pregnancy outcome such as gestational diabetes mellitus (GDM), preeclampsia, and intrauterine growth restriction (IUGR). A disturbed materno-fetal LCPUFA supply is known to be linked with each of these pathologies. Further, a disturbed LCPUFA metabolism is reported to be associated with a number of metabolic disorders. It is likely that LCPUFA supplementation during early pregnancy may be beneficial in improving the health of the mother, improving birth outcome and thereby reducing the risk of diseases in later life.
C1 [Wadhwani, Nisha; Patil, Vidya; Joshi, Sadhana] Bharati Vidyapeeth Univ, Interact Res Sch Hlth Affairs, Dept Nutr Med, Pune Satara Rd, Pune 411043, Maharashtra, India.
C3 Bharati Vidyapeeth Deemed University
RP Joshi, S (corresponding author), Bharati Vidyapeeth Univ, Interact Res Sch Hlth Affairs, Dept Nutr Med, Pune Satara Rd, Pune 411043, Maharashtra, India.
EM srjoshi62@gmail.com
RI JOSHI, Shrikant/E-4451-2011; Wadhwani, Nisha/KDO-6642-2024
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NR 200
TC 34
Z9 37
U1 1
U2 12
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 0952-3278
EI 1532-2823
J9 PROSTAG LEUKOTR ESS
JI Prostaglandins Leukot. Essent. Fatty Acids
PD SEP
PY 2018
VL 136
SI SI
BP 143
EP 152
DI 10.1016/j.plefa.2017.08.002
PG 10
WC Biochemistry & Molecular Biology; Cell Biology; Endocrinology &
   Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology; Endocrinology &
   Metabolism
GA GZ5GK
UT WOS:000449447000018
PM 28888333
DA 2025-06-11
ER

PT J
AU Zyriax, BC
   von Katzler, R
   Jagemann, B
   Westenhoefer, J
   Jensen, HJ
   Harth, V
   Oldenburg, M
AF Zyriax, Birgit-Christiane
   von Katzler, Robert
   Jagemann, Bettina
   Westenhoefer, Joachim
   Jensen, Hans-Joachim
   Harth, Volker
   Oldenburg, Marcus
TI Food offerings on board and dietary intake of European and Kiribati
   seafarers - crosssectional data from the seafarer nutrition study
SO JOURNAL OF OCCUPATIONAL MEDICINE AND TOXICOLOGY
LA English
DT Article
DE Seafarer; Kiribati; Diet; Food offerings; Food choice; Anthropometry
ID METABOLIC SYNDROME; DANISH SEAFARERS; HEALTH; OBESITY; RISK; FISHERMEN;
   STRESS; SHIPS
AB Background: Overweight and cardiovascular risk factors are a common phenomenon in seafarers. According to internal observation particularly crew members from the Pacific Island State of Kiribati are exposed to a high risk. However, in mixed crews, cultural background plays an important role, influencing food choice, and the actual risk.
   Methods: The Seafarer Nutrition Study (SeaNut study) compared dietary factors in 48 Kiribati and 33 European male seafarers recruited from four merchant ships with a high level of Kiribati manning within a German shipping company. Analysis encompassed the assessment of dietary quality on board, satisfaction with prepared dishes, and individual food intake obtained from 24-h recalls in comparison with nutritional recommendations.
   Results: The overall supply of meat, fat and eggs was more than double, whereas the proportions of fruits, vegetables, dairy products and cereals were much lower than recommended. Based on the reported food choices, both groups, but notably Kiribati seafarers, did not reach reference values as to macronutrient, micronutrient and fiber intake. In addition, satisfaction with the meals served, food preferences and knowledge about a healthy diet varied markedly between Kiribati and Europeans.
   Conclusions: The present analysis of the SeaNut study revealed the necessity of future health intervention programs, including the quality of the food supply as well as information about a healthy diet and adequate food selection. In mixed crews, culture-specific differences should be considered, in order to facilitate the long-term success of interventions.
C1 [Zyriax, Birgit-Christiane] Univ Med Ctr Hamburg Eppendorf, Inst Hlth Serv Res Dermatol & Nursing IVDP, Prevent Med & Nutr, Martinistr 52 Bldg O56, D-20246 Hamburg, Germany.
   [von Katzler, Robert; Jensen, Hans-Joachim; Harth, Volker; Oldenburg, Marcus] Univ Med Ctr Hamburg Eppendorf, Inst Occupat & Maritime Med ZfAM, Dept Maritime Med, Hamburg, Germany.
   [Jagemann, Bettina] Univ Med Ctr Hamburg Eppendorf, Med Clin & Polyclin 1, Hamburg, Germany.
   [Westenhoefer, Joachim] Hamburg Univ Appl Sci, Fac Life Sci, Competence Ctr Hlth, Hamburg, Germany.
C3 University of Hamburg; University Medical Center Hamburg-Eppendorf;
   University of Hamburg; University Medical Center Hamburg-Eppendorf;
   University of Hamburg; University Medical Center Hamburg-Eppendorf;
   Hochschule Angewandte Wissenschaft Hamburg
RP Zyriax, BC (corresponding author), Univ Med Ctr Hamburg Eppendorf, Inst Hlth Serv Res Dermatol & Nursing IVDP, Prevent Med & Nutr, Martinistr 52 Bldg O56, D-20246 Hamburg, Germany.
EM bzyriax@uke.de
RI Harth, Volker/AGG-1586-2022
OI Westenhoefer, Joachim/0000-0002-3203-6599
FU shipping company Hamburg Sud "COLUMBUS" Ship management
FX The study was financially and logistically supported by the shipping
   company Hamburg Sud "COLUMBUS" Ship management, which made all four
   vessels available for on-board examination.
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NR 28
TC 17
Z9 17
U1 3
U2 7
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1745-6673
J9 J OCCUP MED TOXICOL
JI J. Occup. Med. Toxicol.
PD FEB 27
PY 2018
VL 13
AR 9
DI 10.1186/s12995-018-0190-0
PG 8
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA FY1EJ
UT WOS:000426554300001
PM 29988947
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Ozler, S
   Oztas, E
   Tokmak, A
   Ergin, M
   Isci, E
   Eren, F
   Pehlivan, S
   Neselioglu, S
   Yilmaz, N
AF Ozler, Sibel
   Oztas, Efser
   Tokmak, Aytekin
   Ergin, Merve
   Isci, Esra
   Eren, Funda
   Pehlivan, Selcen
   Neselioglu, Salim
   Yilmaz, Nafiye
TI The association of thiol/disulphide homeostasis and lipid accumulation
   index with cardiovascular risk factors in overweight adolescents with
   polycystic ovary syndrome
SO CLINICAL ENDOCRINOLOGY
LA English
DT Article
ID INCREASED OXIDATIVE STRESS; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   PRODUCT INDEX; SYNDROME PCOS; WOMEN; MARKER; LIPOPROTEIN; POPULATION;
   PREVALENCE
AB ObjectiveTo assess thiol/disulphide homeostasis and lipid accumulation product index, and to determine whether they are associated with increased cardiovascular disease (CVD) risk or not in overweight adolescents with polycystic ovary syndrome (PCOS).
   DesignCase-control study.
   SettingEducation and Research Hospital.
   PatientsGroup 1: 43 overweight+PCOS, Group 2: 45 normal weight+PCOS, Group 3: 27 overweight adolescents and Group 4: 96 age-matched, normal weight healthy controls.
   InterventionsSerum lipid profiles, hormonal parameters and thiol/disulphide homeostasis were measured. Lipid accumulation index (LAP index) and homeostasis model assessment (HOMA-IR) were calculated.
   Main outcome measuresThe relation between thiol/disulphide homeostasis and LAP index, and increased CVD risk were evaluated in overweight adolescents with PCOS.
   ResultsNative and total thiol levels were significantly lower in overweight+PCOS adolescents when compared with both normal weight PCOS and control adolescents (P = 0002). LAP index values were significantly higher in Group 1 when compared separately with the rest of the three groups (P < 0001). Multivariable logistic regression analysis revealed serum total thiol levels of lower than 40545 mol/l were independently associated with increased risk of CVD in overweight PCOS adolescents (OR: 1019, 95% CI: 1001-1036). In addition, a LAP index greater than 2154 was also associated with increased CVD risk in overweight PCOS adolescents (OR: 1270, 95% CI: 1174-1374).
   ConclusionIn conclusion, we suggest that increased LAP index and decreased total thiol levels may contribute to the increased CVD risk in overweight adolescents with PCOS.
C1 [Ozler, Sibel; Oztas, Efser; Tokmak, Aytekin; Isci, Esra; Yilmaz, Nafiye] Zekai Tahir Burak Womens Hlth Educ & Res Hosp, Dept Obstet & Gynecol, Talatpasa St, TR-06230 Ankara, Turkey.
   [Ergin, Merve; Eren, Funda; Neselioglu, Salim] Yildirim Beyazit Univ, Fac Med, Dept Clin Biochem, Ankara, Turkey.
   [Pehlivan, Selcen] Yildirim Beyazit Univ, Fac Med, Dept Biostat, Ankara, Turkey.
C3 Dr. Zekai Tahir Burak Women's Health Research & Education Hospital;
   Ankara Yildirim Beyazit University; Ankara Yildirim Beyazit University
RP Ozler, S (corresponding author), Zekai Tahir Burak Womens Hlth Educ & Res Hosp, Talatpasa St, TR-06230 Ankara, Turkey.
EM sibel2ozler@gmail.com
RI eren, funda/GXG-4440-2022; neselioglu, salim/F-6853-2013; Oztas,
   Efser/ABE-1088-2020; Ergin, Malik/AGH-2144-2022; Tokmak,
   Aytekin/K-8296-2016
OI neselioglu, salim/0000-0002-0974-5717; Tokmak,
   Aytekin/0000-0001-5739-5689; Yilmaz, Nafiye/0000-0002-4041-297X
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NR 42
TC 28
Z9 28
U1 0
U2 15
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0300-0664
EI 1365-2265
J9 CLIN ENDOCRINOL
JI Clin. Endocrinol.
PD APR
PY 2016
VL 84
IS 4
BP 516
EP 523
DI 10.1111/cen.12965
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA DH0WR
UT WOS:000372505300007
PM 26492953
DA 2025-06-11
ER

PT S
AU Mulvihill, EE
   Burke, AC
   Huff, MW
AF Mulvihill, Erin E.
   Burke, Amy C.
   Huff, Murray W.
BE Stover, PJ
TI Citrus Flavonoids as Regulators of Lipoprotein Metabolism and
   Atherosclerosis
SO ANNUAL REVIEW OF NUTRITION, VOL 36
SE Annual Review of Nutrition
LA English
DT Review; Book Chapter
DE citrus flavonoids; atherosclerosis; lipid metabolism; glucose
   metabolism; adipose tissue; inflammation
ID HEPATOCYTE APO-B; ACTIVATED PROTEIN-KINASE; MESSENGER-RNA LEVELS;
   INSULIN-RESISTANCE; ORANGE JUICE; SYSTEMIC INFLAMMATION; ANTIOXIDANT
   ACTIVITY; SERUM-CHOLESTEROL; HEPATIC STEATOSIS; OXIDATIVE STRESS
AB Citrus flavonoids are polyphenolic compounds with significant biological properties. This review summarizes recent advances in understanding the ability of citrus flavonoids to modulate lipid metabolism, other metabolic parameters related to the metabolic syndrome, and atherosclerosis. Citrus flavonoids, including naringenin, hesperitin, nobiletin, and tangeretin, have emerged as potential therapeutics for the treatment of metabolic dysregulation. Epidemiological studies reveal an association between the intake of citrus flavonoid-containing foods and a decreased incidence of cardiovascular disease. Studies in cell culture and animal models, as well as a limited number of clinical studies, reveal the lipid-lowering, insulin-sensitizing, antihypertensive, and anti-inflammatory properties of citrus flavonoids. In animal models, supplementation of rodent diets with citrus flavonoids prevents hepatic steatosis, dyslipidemia, and insulin resistance primarily through inhibition of hepatic fatty acid synthesis and increased fatty acid oxidation. Citrus flavonoids blunt the inflammatory response in metabolically important tissues including liver, adipose, kidney, and the aorta. The mechanisms underlying flavonoid-induced metabolic regulation have not been completely established, although several potential targets have been identified. In mouse models, citrus flavonoids show marked suppression of atherogenesis through improved metabolic parameters as well as through direct impact on the vessel wall. Recent studies support a role for citrus flavonoids in the treatment of dyslipidemia, insulin resistance, hepatic steatosis, obesity, and atherosclerosis. Larger human studies examining dose, bioavailability, efficacy, and safety are required to promote the development of these promising therapeutic agents.
C1 [Mulvihill, Erin E.; Burke, Amy C.; Huff, Murray W.] Univ Western Ontario, Dept Biochem, London, ON N6A 5B7, Canada.
   [Huff, Murray W.] Univ Western Ontario, Robarts Res Inst, Dept Med, London, ON N6A 5B7, Canada.
   [Mulvihill, Erin E.] Mt Sinai Hosp, Lunenfeld Tanenbaum Res Inst, Toronto, ON M5T 3L9, Canada.
C3 Western University (University of Western Ontario); Western University
   (University of Western Ontario); University Western Ontario Hospital;
   University of Toronto; Sinai Health System Toronto; Lunenfeld Tanenbaum
   Research Institute
RP Mulvihill, EE (corresponding author), Univ Western Ontario, Dept Biochem, London, ON N6A 5B7, Canada.; Mulvihill, EE (corresponding author), Mt Sinai Hosp, Lunenfeld Tanenbaum Res Inst, Toronto, ON M5T 3L9, Canada.
EM erin.mulvihill@utoronto.ca; aburke42@uwo.ca; mhuff@uwo.ca
RI Huff, Murray/G-3307-2011
FU CIHR Funding Source: Medline
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NR 99
TC 170
Z9 187
U1 4
U2 221
PU ANNUAL REVIEWS
PI PALO ALTO
PA 4139 EL CAMINO WAY, PO BOX 10139, PALO ALTO, CA 94303-0897 USA
SN 0199-9885
EI 1545-4312
BN 978-0-8243-2836-8
J9 ANNU REV NUTR
JI Annu. Rev. Nutr.
PY 2016
VL 36
BP 275
EP 299
DI 10.1146/annurev-nutr-071715-050718
PG 25
WC Nutrition & Dietetics
WE Book Citation Index – Science (BKCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA BF4RR
UT WOS:000381633900012
PM 27146015
OA Bronze
DA 2025-06-11
ER

PT J
AU Polesel, DN
   Hirotsu, C
   Nozoe, KT
   Boin, AC
   Bittencourt, L
   Tufik, S
   Andersen, ML
   Hachul, H
AF Polesel, Daniel N.
   Hirotsu, Camila
   Nozoe, Karen T.
   Boin, Andre C.
   Bittencourt, Lia
   Tufik, Sergio
   Andersen, Monica L.
   Hachul, Helena
TI Waist circumference and postmenopause stages as the main associated
   factors for sleep apnea in women: a cross-sectional population-based
   study
SO MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY
LA English
DT Article
DE Obstructive sleep apnea syndrome; Menopause; Waist circumference;
   Postmenopause
ID OXIDATIVE STRESS; INTERMITTENT HYPOXIA; METABOLIC SYNDROME;
   RISK-FACTORS; SAO-PAULO; OBESITY; ADULTS; PREMENOPAUSAL; PERIMENOPAUSE;
   CONSEQUENCES
AB Objective The current study aimed to investigate stages of reproductive aging as an associated factor for obstructive sleep apnea syndrome (OSAS) among women in a representative sample of Sao Paulo, Brazil.
   Methods Four hundred seven women underwent clinical evaluation, polysomnography, and biochemical analysis. Stages of reproductive aging were defined as premenopause, early postmenopause, and late postmenopause.
   Results OSAS was more frequent in the postmenopausal groups, with 68.4% of women affected by severe OSAS belonging to the late postmenopause group. After adjustment for potential confounding factors, associated factors for OSAS, regardless of its severity, were waist circumference, modified Mallampati score IV, and both postmenopause stages. For moderate to severe OSAS and severe OSAS, we found waist circumference and both postmenopause stages to be the main factors. We carried out a receiver operating characteristic curve analysis, which demonstrated that the cutoff value for waist circumference was 87.5 cm, with a maximum of 75.7% accuracy for the classification of women as OSAS or non-OSAS.
   Conclusions OSAS is prevalent in postmenopausal women, especially in late postmenopause. This study highlights the association between waist circumference, early postmenopause and late postmenopause, and severity of OSAS. Our findings suggest that postmenopause stages may potentially exacerbate the presence of sleep disturbance and that reducing waist circumference may be an important strategy for managing OSAS in women.
C1 [Polesel, Daniel N.; Hirotsu, Camila; Nozoe, Karen T.; Boin, Andre C.; Bittencourt, Lia; Tufik, Sergio; Andersen, Monica L.; Hachul, Helena] Univ Fed Sao Paulo, Dept Psychobiol, Sao Paulo, SP, Brazil.
   [Hachul, Helena] Univ Fed Sao Paulo, Dept Gynecol, Sao Paulo, SP, Brazil.
   [Hachul, Helena] Casa Saude Santa Marcelina, Dept Gynecol, Sao Paulo, SP, Brazil.
C3 Universidade Federal de Sao Paulo (UNIFESP); Universidade Federal de Sao
   Paulo (UNIFESP)
RP Hachul, H (corresponding author), Rua Napoleao de Barros 925, BR-04024002 Sao Paulo, SP, Brazil.
EM helena.hachul@hotmail.com
RI Tufik, Sergio/D-7606-2012; Nozoe, Karen/C-6688-2012; Hirotsu,
   Camila/C-1960-2013; Hachul, Helena/G-3608-2012; Bittencourt,
   Lia/C-6551-2012; Polesel, Daniel/J-4908-2013; Levy Andersen,
   Monica/C-7616-2012
OI Hachul, Helena/0000-0002-3661-582X; Nozoe, Karen/0000-0002-8014-8931;
   Hirotsu, Camila/0000-0002-6760-0663; Bittencourt,
   Lia/0000-0001-7738-0927; Polesel, Daniel/0000-0003-4105-0752; Levy
   Andersen, Monica/0000-0002-1894-6748
FU Associacao Fundo de Incentivo a Pesquisa; Coordenacao de Aperfeicoamento
   de Pessoal de Nivel Superior; Conselho Nacional de Pesquisa; Sao Paulo
   Research Foundation [2013/14945-7]; Fundacao de Amparo a Pesquisa do
   Estado de Sao Paulo (FAPESP) [13/14945-7] Funding Source: FAPESP
FX This research was supported by fellowships from Associacao Fundo de
   Incentivo a Pesquisa, Coordenacao de Aperfeicoamento de Pessoal de Nivel
   Superior, Conselho Nacional de Pesquisa, and The Sao Paulo Research
   Foundation (grant 2013/14945-7 to D. N. P.). L. B., M. L. A. and S. T.
   are recipients of Conselho Nacional de Pesquisa fellowships.
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NR 67
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Z9 41
U1 0
U2 10
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1072-3714
EI 1530-0374
J9 MENOPAUSE
JI Menopause-J. N. Am. Menopause Soc.
PD AUG
PY 2015
VL 22
IS 8
BP 835
EP 844
DI 10.1097/GME.0000000000000406
PG 10
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA CP4KN
UT WOS:000359850500008
PM 25668307
DA 2025-06-11
ER

PT J
AU Beach, SRH
   Lei, MK
   Brody, GH
   Dogan, MV
   Philibert, RA
AF Beach, Steven R. H.
   Lei, Man Kit
   Brody, Gene H.
   Dogan, Meeshanthini V.
   Philibert, Robert A.
TI Higher levels of protective parenting are associated with better young
   adult health: exploration of mediation through epigenetic influences on
   pro-inflammatory processes
SO FRONTIERS IN PSYCHOLOGY
LA English
DT Article
DE epigenetic; methylation; african american; parenting; CpG; TNF; SES
ID AFRICAN-AMERICAN; SUBSTANCE USE; METABOLIC SYNDROME; DNA METHYLATION;
   CHILDHOOD; COMPETENCE; EXPERIENCE; PATHWAYS; DISEASE; STRESS
AB The current investigation was designed to examine the association of parenting during late childhood and early adolescence, a time of rapid physical development, with biological propensity for inflammation. Based on life course theory, it was hypothesized that parenting during this period of rapid growth and development would be associated with biological outcomes and self-reported health assessed in young adulthood. It was expected that association of parenting with health would be mediated either by effects on methylation of a key inflammatory factor, Tumor necrosis factor (TNF), or else by association with a pro-inflammatory shift in the distribution of mononuclear blood cells. Supporting expectations, in a sample of 398 African American youth residing in rural Georgia, followed from age 11 to age 19, parenting at ages 11-13 was associated with youth reports of better health at age 19. We found that parenting was associated with changes in TNF methylation as well as with changes in cell-type composition. However, whereas methylation of TNF was a significant mediator of the association of parenting with young adult health, variation in mononuclear white blood cell types was not a significant mediator of the association of parenting with young adult health. The current research suggests the potential value of examining the health-related effects of parenting in late childhood and early adolescence. Further examination of protection against pro-inflammatory tendencies conferred by parenting appears warranted.
C1 [Beach, Steven R. H.; Lei, Man Kit; Brody, Gene H.] Univ Georgia, Ctr Family Res, Athens, GA 30602 USA.
   [Dogan, Meeshanthini V.] Univ Iowa, Dept Biomed Engn, Iowa City, IA 52242 USA.
   [Philibert, Robert A.] Univ Iowa, Dept Psychiat, Iowa City, IA 52242 USA.
C3 University System of Georgia; University of Georgia; University of Iowa;
   University of Iowa
RP Beach, SRH (corresponding author), Univ Georgia, Ctr Family Res, 1095 Coll Stn Rd, Athens, GA 30602 USA.
EM srhbeach@uga.edu
RI Beach, Steven/MBH-1541-2025; Lei, Man/AAM-9616-2020
OI Philibert, Robert/0000-0001-7822-4977; Lei, Man-Kit/0000-0002-7757-6548
FU National Institute of Child Health and Human Development
   [5R01HD030588-16A1]; National Institute on Drug Abuse [1P30DA027827]
FX This research was supported by Award 5R01HD030588-16A1 from the National
   Institute of Child Health and Human Development and Award 1P30DA027827
   from the National Institute on Drug Abuse. The content is solely the
   responsibility of the authors and does not necessarily represent the
   official views of the National Institute of Child Health and Human
   Development, the National Institute on Drug Abuse, or the National
   Institutes of Health.
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NR 62
TC 21
Z9 22
U1 0
U2 22
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-1078
J9 FRONT PSYCHOL
JI Front. Psychol.
PD MAY 28
PY 2015
VL 6
AR 676
DI 10.3389/fpsyg.2015.00676
PG 11
WC Psychology, Multidisciplinary
WE Social Science Citation Index (SSCI)
SC Psychology
GA CJ4XX
UT WOS:000355492200001
PM 26074840
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Fantidis, P
   Eladio, S
   Ibrahim, T
   Tomas, P
   Antonio, CJ
   Ramón, GJ
AF Fantidis, Panayotis
   Eladio, Sanchez
   Ibrahim, Tarhini
   Tomas, Pineda
   Jose Antonio, Corrales
   Jose Ramon, Gonzalez
TI Is there a Role for Cortisol in the Accumulation of Lipids in the Intima
   a Crucial Step of Atherogenesis?
SO CURRENT VASCULAR PHARMACOLOGY
LA English
DT Article
DE Atherogenesis; intima; penetration and efflux of cholesterol; cortisol
ID PITUITARY-ADRENAL AXIS; METABOLIC SYNDROME; INSULIN-RESISTANCE;
   FATTY-ACIDS; 11-BETA-HYDROXYSTEROID DEHYDROGENASE;
   GLUCOCORTICOID-RECEPTOR; CORONARY-ARTERY; ATHEROSCLEROTIC LESIONS;
   HORMONAL-REGULATION; CHOLESTEROL EFFLUX
AB Accumulation of lipids in the intima is the initial and crucial step in atherogenesis, but, this step is not always synonymous with atherogenesis. The factors that trigger the mechanisms modulating lipid accumulation in the vessel wall and in the subsequent development of atherosclerotic plaque remain unclear. In this review we evaluate whether atherogenesis is modulated by cortisol, the end hormone of the stress-related anti-inflammatory system.
   The amount of accumulated lipids in the intima depends on the balance between the penetration and efflux of cholesterol from the artery wall. We assess whether cortisol is involved in this balance. Cortisol can increase the penetration of lipids, and, simultaneously, might reduce their efflux from the intima. We also report a critical analysis on whether atherogenesis, which has a local nature, can be modulated by a systemic factor. In addition, we comment on the synergistic action of cortisol with insulin in atherogenesis, and consider relevant recent clinical evidence regarding the role of cortisol in atherosclerosis.
   Glucocorticoids, by triggering the mechanisms that favor the penetration of lipids in the intima, and modulating factors that control the efflux of cholesterol from the artery wall, may lead to the formation of atherosclerotic plaques. Thus, cortisol may have a role in atherogenesis. This may have important clinical, therapeutic and preventive implications.
RP Fantidis, P (corresponding author), C Sierra Nevada 126, Cotos De Monterrey 28729, Venturada Madri, Spain.
EM pfantidis@yahoo.es
OI Sanchez, Eladio/0000-0002-7805-4303
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NR 84
TC 8
Z9 8
U1 0
U2 6
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1570-1611
EI 1875-6212
J9 CURR VASC PHARMACOL
JI Current Vascular Pharmacology
PY 2015
VL 13
IS 5
BP 587
EP 593
DI 10.2174/1570161112666141127163307
PG 7
WC Pharmacology & Pharmacy; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Cardiovascular System & Cardiology
GA CQ3LF
UT WOS:000360503100005
PM 25440596
DA 2025-06-11
ER

PT J
AU Franco, JG
   Lisboa, PC
   Lima, ND
   Peixoto-Silva, N
   Maia, LA
   Oliveira, E
   Passos, MCF
   de Moura, EG
AF Franco, J. G.
   Lisboa, P. C.
   da Silva Lima, N.
   Peixoto-Silva, N.
   Maia, L. A.
   Oliveira, E.
   Passos, M. C. F.
   de Moura, E. G.
TI Resveratrol Prevents Hyperleptinemia and Central Leptin Resistance in
   Adult Rats Programmed by Early Weaning
SO HORMONE AND METABOLIC RESEARCH
LA English
DT Article
DE metabolic programming; polyphenol; appetite control; visceral adiposity
ID METABOLIC SYNDROME; PROLACTIN INHIBITION; DEVELOPMENTAL PLASTICITY;
   MITOCHONDRIAL-FUNCTION; LACTATION PROGRAMS; THYROID-FUNCTION;
   BODY-WEIGHT; OBESITY; MICE; FAT
AB We have previously shown that early weaning in rats increases the risk of obesity and insulin resistance at adulthood, and leptin resistance can be a prime factor leading to these changes. Resveratrol is reported to decrease oxidative stress, insulin resistance, and cardiovascular risk. However, there is no report about its effect on leptin resistance. Thus, in this study we have evaluated resveratrol-preventing effect on the development of visceral obesity, insulin, and leptin resistance in rats programmed by early weaning. To induce early weaning, lactating dams were separated into 2 groups: early weaning (EW) - dams were wrapped with a bandage to interrupt lactation in the last 3 days of lactation and control (C) - dams whose pups had free access to milk during throughout lactation period (21 days). At 150 days-old, EW off spring were subdivided into 2 groups: EW + res - treated with resveratrol solution (30 mg/kg BW/day) or EW receiving equal volume of vehicle solution, both given by gavage during 30 days. Control group received vehicle solution. Resveratrol prevented the higher body weight, hyperphagia, visceral obesity, hyperleptinemia, hyperglycemia, insulin resistance, and hypoadiponectinemia at adulthood in animals that were early weaned. Leptin resistance, associated with lower JAK2 and pSTAT3 and higher NPY in hypothalamus of EW rats were also normalized by resveratrol. The present results suggest that resveratrol is useful as therapeutic tool in treating obesity, mainly because it prevents the development of central leptin resistance.
C1 [Franco, J. G.; Lisboa, P. C.; da Silva Lima, N.; Peixoto-Silva, N.; Maia, L. A.; Oliveira, E.; Passos, M. C. F.; de Moura, E. G.] Univ Estado Rio de Janeiro, Roberto Alcantara Gomes Biol Inst, Dept Physiol Sci, BR-20550030 Rio De Janeiro, RJ, Brazil.
C3 Universidade do Estado do Rio de Janeiro
RP de Moura, EG (corresponding author), Univ Estado Rio de Janeiro, Inst Biol, Dept Ciencias Fisiol, 5 Andar,Av 28 Setembro 87, BR-20550030 Rio De Janeiro, RJ, Brazil.
EM egberto@pq.cnpq.br
RI LIMA, NATALIA/K-5674-2015; Peixoto-Silva, Nayara/P-5072-2015; Moura,
   Egberto/H-1270-2012; Lisboa, Patricia/H-8336-2015
OI Moura, Egberto/0000-0002-1159-7549; Lisboa, Patricia/0000-0002-2477-4364
FU National Council for Scientific and Technological Development (Conselho
   Nacional de Desenvolvimento Cientifico e Tecnologico-CNPq); Coordination
   for the Enhancement of Higher Education Personnel (Coordenacao de
   Aperfeicoamento de Pessoal de Nivel Superior-CAPES); State of Rio de
   Janeiro Carlos Chagas Filho Research Foundation (Fundacao Carlos Chagas
   Filho de Amparo a Pesquisa do Estado do Rio de Janeiro-FAPERJ)
FX This research was supported by National Council for Scientific and
   Technological Development (Conselho Nacional de Desenvolvimento
   Cientifico e Tecnologico-CNPq), Coordination for the Enhancement of
   Higher Education Personnel (Coordenacao de Aperfeicoamento de Pessoal de
   Nivel Superior-CAPES), and State of Rio de Janeiro Carlos Chagas Filho
   Research Foundation (Fundacao Carlos Chagas Filho de Amparo a Pesquisa
   do Estado do Rio de Janeiro-FAPERJ).
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NR 66
TC 15
Z9 18
U1 0
U2 14
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0018-5043
EI 1439-4286
J9 HORM METAB RES
JI Horm. Metab. Res.
PD SEP
PY 2014
VL 46
IS 10
BP 728
EP 735
DI 10.1055/s-0034-1375688
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA AO8DL
UT WOS:000341583400010
PM 24956416
DA 2025-06-11
ER

PT J
AU Garcia-Ruiz, C
   Fernandez-Checa, JC
AF Garcia-Ruiz, Carmen
   Fernandez-Checa, Jose C.
TI To binge or not to binge: Binge drinking disrupts glucose homeostasis by
   impairing hypothalamic but not liver insulin signaling
SO HEPATOLOGY
LA English
DT Review
ID ALCOHOL-CONSUMPTION; CELL-DEATH; RESISTANCE; BRAIN; OBESITY; STRESS
AB Individuals with a history of binge drinking have an increased risk of developing the metabolic syndrome and type 2 diabetes. Whether binge drinking impairs glucose homeostasis and insulin action is unknown. To test this, we treated Sprague-Dawley rats daily with alcohol (3 g/kg) for three consecutive days to simulate human binge drinking and found that these rats developed and exhibited insulin resistance even after blood alcohol concentrations had become undetectable. The animals were resistant to insulin for up to 54 hours after the last dose of ethanol, chiefly a result of impaired hepatic and adipose tissue insulin action. Because insulin regulates hepatic glucose production and white adipose tissue lipolysis, in part through signaling in the central nervous system, we tested whether binge drinking impaired brain control of nutrient partitioning. Rats that had consumed alcohol exhibited impaired hypothalamic insulin action, defined as the ability of insulin infused into the mediobasal hypothalamus to suppress hepatic glucose production and white adipose tissue lipolysis. Insulin signaling in the hypothalamus, as assessed by insulin receptor and AKT phosphorylation, decreased after binge drinking. Quantitative polymerase chain reaction showed increased hypothalamic inflammation and expression of protein tyrosine phosphatase 1B (PTP1B), a negative regulator of insulin signaling. Intrace-rebroventricular infusion of CPT-157633, a small-molecule inhibitor of PTP1B, prevented binge drinking-induced glucose intolerance. These results show that, in rats, binge drinking induces systemic insulin resistance by impairing hypothalamic insulin action and that this effect can be prevented by inhibition of brain PTP1B.
C1 [Garcia-Ruiz, Carmen] Hosp Clin Barcelona, Liver Unit, IDIBAPS, Dept Cell Death & Proliferat,IIBB,CSIC, Barcelona, Spain.
   CIBEREHD, Barcelona, Spain.
   Univ So Calif, Keck Sch Med, Southern Calif Res Ctr ALPD & Cirrhosis, Los Angeles, CA 90033 USA.
C3 Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Instituto
   de Investigaciones Biomedicas de Barcelona (IIBB); University of
   Barcelona; Hospital Clinic de Barcelona; IDIBAPS; CIBER - Centro de
   Investigacion Biomedica en Red; CIBEREHD; University of Southern
   California
RP Garcia-Ruiz, C (corresponding author), Hosp Clin Barcelona, Liver Unit, IDIBAPS, Dept Cell Death & Proliferat,IIBB,CSIC, Barcelona, Spain.
RI , Carmen/L-8211-2014; Fernandez-Checa, Jose Carlos/L-8342-2014
OI , Carmen/0000-0002-2652-6102; Fernandez-Checa, Jose
   Carlos/0000-0003-3422-2990
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NR 20
TC 1
Z9 3
U1 1
U2 9
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0270-9139
EI 1527-3350
J9 HEPATOLOGY
JI Hepatology
PD JUN
PY 2013
VL 57
IS 6
BP 2535
EP 2538
DI 10.1002/hep.26423
PG 4
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 162PC
UT WOS:000320276400047
PM 23533008
OA Bronze
DA 2025-06-11
ER

PT J
AU Luo, Y
   Rana, P
   Will, Y
AF Luo, Yi
   Rana, Payal
   Will, Yvonne
TI Palmitate Increases the Susceptibility of Cells to Drug-Induced
   Toxicity: An In Vitro Method to Identify Drugs With Potential
   Contraindications in Patients With Metabolic Disease
SO TOXICOLOGICAL SCIENCES
LA English
DT Article
ID FREE FATTY-ACIDS; INDUCED OXIDATIVE STRESS; INSULIN-RESISTANCE;
   CYCLOSPORINE-A; LIVER; OBESITY; LIPOTOXICITY; METHOTREXATE; ACTIVATION;
   EXPRESSION
AB Fatty acids are an important source of energy. Excessive energy intake results in elevated levels of free fatty acids that are thought to be the pathogenic factors causing metabolic disorders such as dyslipidemia, obesity, insulin resistance, diabetes, and fatty liver. Underlying metabolic disorders have been suggested to be a predisposing factor for drug-induced liver injury. The steadily expanding population with metabolic disease may pose a higher risk for drug-induced toxicity. In order to understand the interaction of free fatty acids and drug-induced toxicity at the cellular level, we explored whether the saturated free fatty acid palmitate could modulate drug-induced cytotoxicity in HepG2 cells. A number of drugs known to induce hepatotoxicity in humans were selected to test this hypothesis. Drugs without reported hepatotoxicity were also tested to evaluate the specificity of the palmitate-induced effects. We demonstrate that palmitate, at sublethal concentrations, was able to potentiate the cytotoxicity and/or apoptosis induced by some but not all drugs tested. The palmitate and drug coincubation potentiated toxicity, which when combined with the plasma maximum concentration (C-max), allowed us to identify idiosyncratic toxic drugs that were not flagged in previously deployed cytotoxicity assays. Our data suggest that treatment of cells with palmitate improves the sensitivity to detect compounds with risk of inducing idiosyncratic liver toxicity. Furthermore, this assay may be used to identify compounds that have higher safety risks in a population with metabolic syndrome.
C1 [Luo, Yi; Rana, Payal; Will, Yvonne] Pfizer Inc, Pfizer Global Res & Dev, Worldwide Med Chem, Compound Safety Predict, Groton, CT 06340 USA.
C3 Pfizer; Pfizer USA
RP Luo, Y (corresponding author), Pfizer Inc, Pfizer Global Res & Dev, Worldwide Med Chem, Compound Safety Predict, Groton, CT 06340 USA.
EM yi.luo@pfizer.com
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NR 44
TC 30
Z9 32
U1 0
U2 7
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1096-6080
EI 1096-0929
J9 TOXICOL SCI
JI Toxicol. Sci.
PD OCT
PY 2012
VL 129
IS 2
BP 346
EP 362
DI 10.1093/toxsci/kfs208
PG 17
WC Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Toxicology
GA 009PM
UT WOS:000309037700011
PM 22700542
OA Bronze
DA 2025-06-11
ER

PT J
AU Alisi, A
   Pastore, A
   Ceccarelli, S
   Panera, N
   Gnani, D
   Bruscalupi, G
   Massimi, M
   Tozzi, G
   Piemonte, F
   Nobili, V
AF Alisi, Anna
   Pastore, Anna
   Ceccarelli, Sara
   Panera, Nadia
   Gnani, Daniela
   Bruscalupi, Giovannella
   Massimi, Mara
   Tozzi, Giulia
   Piemonte, Fiorella
   Nobili, Valerio
TI Emodin Prevents Intrahepatic Fat Accumulation, Inflammation and Redox
   Status Imbalance During Diet-Induced Hepatosteatosis in Rats
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE hepatosteatosis; emodin; high fat diet; high fructose diet; redox status
ID LIVER-DISEASE; NONALCOHOLIC STEATOHEPATITIS; OXIDATIVE STRESS;
   VITAMIN-E; INSULIN-RESISTANCE; METABOLIC SYNDROME; HIGH-FRUCTOSE;
   PATHOGENESIS; OBESITY; CELLS
AB High-fat and/or high-carbohydrate diets may predispose to several metabolic disturbances including liver fatty infiltration (hepatosteatosis) or be associated with necro-inflammation and fibrosis (steatohepatitis). Several studies have emphasized the hepatoprotective effect of some natural agents. In this study, we investigated the potential therapeutic effects of the treatment with emodin, an anthraquinone derivative with anti-oxidant and anti-cancer abilities, in rats developing diet-induced hepatosteatosis and steatohepatitis. Sprague-Dawley rats were fed a standard diet (SD) for 15 weeks, or a high-fat/high-fructose diet (HFD/HF). After 5 weeks, emodin was added to the drinking water of some of the SD and HFD/HF rats. The experiment ended after an additional 10 weeks. Emodin-treated HFD/HF rats were protected from hepatosteatosis and metabolic derangements usually observed in HFD/HF animals. Furthermore, emodin exerted anti-inflammatory activity by inhibiting the HFD/HF-induced increase of tumor necrosis factor (TNF)-alpha. Emodin also affected the hepatocytes glutathione homeostasis and levels of the HFD/HF-induced increase of glutathionylated/phosphorylated phosphatase and tensin homolog (PTEN). In conclusion, we demonstrated that a natural agent such as emodin can prevent hepatosteatosis, preserving liver from pro-inflammatory and pro-oxidant damage caused by HFD/HF diet. These findings are promising, proposing emodin as a possible hindrance to progression of hepatosteatosis into steatohepatitis.
C1 [Alisi, Anna; Ceccarelli, Sara; Panera, Nadia; Gnani, Daniela; Nobili, Valerio] IRCCS, Liver Unit, Bambino Gesu Childrens Hosp, I-00165 Rome, Italy.
   [Pastore, Anna] IRCCS, Biochem Lab, Bambino Gesu Childrens Hosp, I-00165 Rome, Italy.
   [Bruscalupi, Giovannella] Univ Roma La Sapienza, Dept Biol & Biotechnol C Darwin, I-00185 Rome, Italy.
   [Massimi, Mara] Univ Aquila, Dept Basic & Appl Biol, I-67010 Laquila, Italy.
   [Tozzi, Giulia; Piemonte, Fiorella] IRCCS, Bambino Gesu Childrens Hosp, Neuromuscular & Neurodegenerat Dis Unit, I-00165 Rome, Italy.
C3 IRCCS Bambino Gesu; IRCCS Bambino Gesu; Sapienza University Rome;
   University of L'Aquila; IRCCS Bambino Gesu
RP Alisi, A (corresponding author), IRCCS, Liver Unit, Bambino Gesu Childrens Hosp, I-00165 Rome, Italy.
EM anna.alisi@opbg.net; anna.pastore@opbg.net; sara.ceccarelli@opbg.net;
   nadia.panera@opbg.net; daniela.gnani@yahoo.it;
   giovannella.bruscalupi@uniroma1.it; mara.massimi@univaq.it;
   giulia.tozzi@opbg.net; fiorella.piemonte@opbg.net; nobili66@yahoo.it
RI gnani, Daniela/AAN-1929-2020; Ceccarelli, Sara/X-5822-2019; Tozzi,
   Giulia/K-8605-2018; Alisi, Anna/A-6469-2010; Nobili,
   Valerio/K-8670-2018; Piemonte, Fiorella/A-2809-2014; Pastore,
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OI Piemonte, Fiorella/0000-0003-1825-9347; Pastore,
   Anna/0000-0002-0990-9419; Alisi, Anna/0000-0001-7241-6329; PANERA,
   NADIA/0000-0002-5365-3123; massimi, mara/0000-0002-9569-816X; Tozzi,
   Giulia/0000-0002-1745-2797; nobili, valerio/0000-0002-4570-3979; Gnani,
   Daniela/0000-0002-5857-3456; Ceccarelli, Sara/0000-0001-6313-3247
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NR 54
TC 52
Z9 55
U1 1
U2 22
PU MDPI AG
PI BASEL
PA POSTFACH, CH-4005 BASEL, SWITZERLAND
SN 1661-6596
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD FEB
PY 2012
VL 13
IS 2
BP 2276
EP 2289
DI 10.3390/ijms13022276
PG 14
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 898DM
UT WOS:000300715700064
PM 22408453
OA Green Submitted, gold, Green Published
DA 2025-06-11
ER

PT J
AU Wang, TG
   Bi, YF
   Xu, M
   Huang, Y
   Xu, Y
   Li, XY
   Wang, WQ
   Ning, G
AF Wang, Tiange
   Bi, Yufang
   Xu, Min
   Huang, Yun
   Xu, Yu
   Li, Xiaoying
   Wang, Weiqing
   Ning, Guang
TI Serum uric acid associates with the incidence of type 2 diabetes in a
   prospective cohort of middle-aged and elderly Chinese
SO ENDOCRINE
LA English
DT Article
DE Serum uric acid; Type 2 diabetes; Prospective study
ID IMPAIRED FASTING GLUCOSE; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   OXIDATIVE STRESS; RENAL-DISEASE; RISK-FACTORS; HYPERURICEMIA;
   HYPERTENSION; ANTIOXIDANT; CELLS
AB This study is to prospectively investigate the association between serum uric acid and the incidence of type 2 diabetes in middle-aged and elderly Chinese. This study consisted of 924 non-diabetic adults aged 40 years or older at baseline. Subjects who received antidiabetic therapies and those who responded positively to the 75-g oral glucose tolerance test according to the 1999 World Health Organization criteria were diagnosed as having type 2 diabetes. Ninety-eight subjects developed type 2 diabetes during the 3.5-year follow-up. The hazard ratio (HR) for incident diabetes was 1.50 [95% confidence interval (CI) 1.18-1.92] for the highest sex-specific quartile of serum uric acid compared with the lowest after controlling for confounders. Participants with hyperuricemia had an HR of 1.95 (95% CI 1.11-3.44) for incident diabetes compared with those without hyperuricemia. Compared with the lowest quartile, the highest quartile had an HR for incident diabetes of 2.45 (95% CI 1.39-4.33) in men and 1.39 (95% CI 1.04-1.84) in women after fully adjustment. Adding serum uric acid to a model of conventional risk factors for diabetes improved the area under the curve for prediction of type 2 diabetes by 5%. Serum uric acid was an independent predictor of incident type 2 diabetes in middle-aged and elderly Chinese.
C1 [Wang, Tiange; Bi, Yufang; Xu, Min; Huang, Yun; Xu, Yu; Li, Xiaoying; Wang, Weiqing; Ning, Guang] Shanghai Jiao Tong Univ, Shanghai Inst Endocrine & Metab Dis, Rui Jin Hosp,Shanghai Clin Ctr Endocrine & Metab, Dept Endocrine & Metab Dis,Sch Med, Shanghai 200025, Peoples R China.
   [Li, Xiaoying; Ning, Guang] E Inst Shanghai Univ, State Key Lab Med Genom, Shanghai 200025, Peoples R China.
C3 Shanghai Jiao Tong University; Chinese Academy of Sciences
RP Wang, WQ (corresponding author), Shanghai Jiao Tong Univ, Shanghai Inst Endocrine & Metab Dis, Rui Jin Hosp,Shanghai Clin Ctr Endocrine & Metab, Dept Endocrine & Metab Dis,Sch Med, 197 Rui Jin 2nd Rd, Shanghai 200025, Peoples R China.
EM wqingw@hotmail.com
RI Chen, Hao/JHT-2948-2023; Martinez, Ramfis/I-7205-2019; bi,
   yu/JOK-3859-2023; Wang, Tiange/MCX-9826-2025
OI Wang, Tiange/0000-0003-0723-489X; Li, Xiaoying/0000-0002-9383-5757
FU Key Laboratory for Endocrine and Metabolic Diseases of Ministry of
   Chinese Public Health [1994DP131044]; National Science Foundation of
   China [30911120493]; National Key New Drug Creation and Manufacturing
   Program [2008ZX09312/019]; Ministry of Science & Technology of China
   [2008BAI52B03]; Shanghai Committee of Science and Technology
   [08dj1400602]
FX This study would not have been possible without the involvement of the
   participants. We are very grateful to Lu Qi from Department of
   Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA
   for critical reading of the manuscript. This study was supported by the
   grants from Key Laboratory for Endocrine and Metabolic Diseases of
   Ministry of Chinese Public Health (No. 1994DP131044), National Science
   Foundation of China (No. 30911120493), National Key New Drug Creation
   and Manufacturing Program (2008ZX09312/019), the National Key Project of
   Scientific and Technical Supporting Programs Funded by Ministry of
   Science & Technology of China (No. 2008BAI52B03) and Shanghai Committee
   of Science and Technology (No. 08dj1400602).
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NR 30
TC 65
Z9 76
U1 1
U2 21
PU HUMANA PRESS INC
PI TOTOWA
PA 999 RIVERVIEW DRIVE SUITE 208, TOTOWA, NJ 07512 USA
SN 1355-008X
J9 ENDOCRINE
JI Endocrine
PD AUG
PY 2011
VL 40
IS 1
BP 109
EP 116
DI 10.1007/s12020-011-9449-2
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 801AN
UT WOS:000293408900017
PM 21431449
DA 2025-06-11
ER

PT J
AU Xia, M
   Zhang, C
   Boini, KM
   Thacker, AM
   Li, PL
AF Xia, Min
   Zhang, Chun
   Boini, Krishna M.
   Thacker, Audrey M.
   Li, Pin-Lan
TI Membrane raft-lysosome redox signalling platforms in coronary
   endothelial dysfunction induced by adipokine visfatin
SO CARDIOVASCULAR RESEARCH
LA English
DT Article
DE Lipid rafts; Transmembrane signalling; Coronary artery; Oxidative
   stress; Sphingolipids
ID COLONY-ENHANCING FACTOR; EPICARDIAL ADIPOSE-TISSUE; ACID
   SPHINGOMYELINASE; SERUM VISFATIN; LIPID RAFTS; CERAMIDE; ACTIVATION;
   EXPRESSION; FAT
AB Aims The adipokine visfatin, produced during obesity, has been reported to participate in the development of cardiovascular disease associated with metabolic syndrome. The present study was designed to test a hypothesis that visfatin causes coronary endothelial dysfunction through lysosome trafficking and fusion to cell membranes, membrane raft (MR) clustering, and formation of redox signalosomes.
   Methods and results By using confocal microscopy, it was found that visfatin, but not adiponectin, stimulated NADPH oxidase (NOX) subunits, gp91(phox) aggregation in MR clusters and p47(phox) translocation to these MR clusters in bovine coronary arterial endothelial cells (CAECs), leading to activation of NOX with a 2.5-fold increase in O-2(-) production. A signalling lipid, ceramide, was found to be enriched in such membrane MR-NOX complexes of CAECs. Lysosomal fluorescent dye (FM1-43) quenching and de-quenching revealed that visfatin induced the fusion of lysosomes to cell membranes and incorporation of acid sphingomyelinase and its product, ceramide, in such MR-NOX signalling platforms. Functionally, visfatin significantly attenuated endothelium-dependent vasodilation in small coronary arteries (by 80%), which was blocked by lysosomal function inhibitor and MR disruptors.
   Conclusion These results suggest that lysosome-associated molecular trafficking and consequent ceramide accumulation in cell membrane may mediate the assembly of NOX subunits and their activation in response to adipokine visfatin in CAECs, thereby producing endothelial dysfunction in coronary circulation.
C1 [Xia, Min; Zhang, Chun; Boini, Krishna M.; Thacker, Audrey M.; Li, Pin-Lan] Virginia Commonwealth Univ, Dept Pharmacol & Toxicol, Richmond, VA 23298 USA.
C3 Virginia Commonwealth University
RP Li, PL (corresponding author), Virginia Commonwealth Univ, Dept Pharmacol & Toxicol, Med Coll Virginia Campus,410 N 12th St, Richmond, VA 23298 USA.
EM pli@vcu.edu
RI Boini, Krishna/H-3548-2011; Xia, Min/C-2084-2012
OI Boini, Krishna M./0000-0003-4284-0780
FU National Institutes of Health [HL-057244, HL-075316, HL-091464]
FX This study was supported by grants from the National Institutes of
   Health (grant nos HL-057244, HL-075316, and HL-091464).
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NR 39
TC 52
Z9 57
U1 0
U2 11
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0008-6363
EI 1755-3245
J9 CARDIOVASC RES
JI Cardiovasc. Res.
PD FEB
PY 2011
VL 89
IS 2
BP 401
EP 409
DI 10.1093/cvr/cvq286
PG 9
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 706KI
UT WOS:000286216900020
PM 20823276
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Anfossi, G
   Russo, I
   Bonomo, K
   Trovati, M
AF Anfossi, Giovanni
   Russo, Isabella
   Bonomo, Katia
   Trovati, Mariella
TI The Cardiovascular Effects of Metformin: Further Reasons to Consider An
   Old Drug as a Cornerstone in the Therapy of Type 2 Diabetes Mellitus
SO CURRENT VASCULAR PHARMACOLOGY
LA English
DT Article
DE AMP-activated protein kinase; diabetic macrovascular disease; metformin;
   oxidative stress; type 2 diabetes mellitus
ID ACTIVATED PROTEIN-KINASE; ENDOTHELIUM-DEPENDENT VASODILATION; C-REACTIVE
   PROTEIN; IMPAIRED GLUCOSE-TOLERANCE; TISSUE ADIPONECTIN LEVELS;
   GLYCATION END-PRODUCTS; FACTOR-KAPPA-B; INSULIN-RESISTANCE;
   ADIPOSE-TISSUE; METABOLIC SYNDROME
AB Cardiovascular events occurring in type 2 diabetes (T2DM) are a major problem in clinical practice. In particular, the risk of myocardial infarction (MI) presented by patients affected by T2DM without previous cardiac events is similar to that of non-diabetic patients with previous MI. To reduce the elevated cardiovascular risk associated with T2DM, tight glycemic control and aggressive therapy against all known cardiovascular risk factors are strictly required. Despite the role played by hyperglycemia in the pathogenesis of cardiovascular events, studies showing an improvement of cardiovascular outcomes by anti-hyperglycemic or hypoglycemic agents are not conclusive. The United Kingdom Prospective Diabetes Study (UKPDS) demonstrated that in obese type 2 diabetic patients metformin reduces the risk of MI more than sulphonylureas or insulin. This observation identified metformin as the first-line treatment for T2DM. The vasoprotective role of metformin is largely independent of its hypoglycemic action and has been ascribed to pleiotropic effects. The present review considers the putative beneficial action exerted by metformin on arterial vessels by evaluating its effects on lipids, inflammation, hemostasis, endothelial and platelet function and vessel wall abnormalities. Furthermore, the molecular mechanisms of the beneficial metabolic and vascular effects of metformin will be considered, with a particular attention for its ability to activate AMP-activated protein kinase.
C1 Univ Turin, San Luigi Gonzaga Hosp, San Luigi Gonzaga Fac Med, Internal Med Univ Unit 3, I-10043 Turin, Italy.
   Univ Turin, San Luigi Gonzaga Hosp, Dept Clin & Biol Sci, I-10043 Turin, Italy.
C3 University of Turin; Azienda Ospedaliero-Universitaria San Luigi
   Gonzaga; University of Turin; Azienda Ospedaliero-Universitaria San
   Luigi Gonzaga
RP Anfossi, G (corresponding author), Univ Turin, San Luigi Gonzaga Fac Med, I-10043 Turin, Italy.
EM giovanni.anfossi@unito.it
RI Russo, Isabella/AAC-5779-2020
OI Russo, Isabella/0000-0002-2921-1763; TROVATI,
   MARIELLA/0000-0003-4397-8060
FU Italian Ministero dell'Istruzione, Universita e Ricerca (MIUR); Regione
   Piemonte
FX This study was supported by a grant from Italian Ministero
   dell'Istruzione, Universita e Ricerca (MIUR) COFIN 2004 within the
   project "The molecular basis of insulin resistance and their importance
   in the pathogenesis of the alterations of the vessel wall", Local
   Coordinator: Giovanni Anfossi, National Coordinator: Amalia Bosia and by
   2 grants from Regione Piemonte (years 2004 and 2006).
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NR 154
TC 53
Z9 69
U1 0
U2 6
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1570-1611
EI 1875-6212
J9 CURR VASC PHARMACOL
JI Current Vascular Pharmacology
PD MAY
PY 2010
VL 8
IS 3
BP 327
EP 337
DI 10.2174/157016110791112359
PG 11
WC Pharmacology & Pharmacy; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Cardiovascular System & Cardiology
GA 589FN
UT WOS:000277132400003
PM 19485923
DA 2025-06-11
ER

PT J
AU Giordano, GM
   Brando, F
   Pezzella, P
   Angelis, MD
   Mucci, A
   Galderisi, S
AF Giordano, Giulia M. M.
   Brando, Francesco
   Pezzella, Pasquale
   Angelis, Maria De
   Mucci, Armida
   Galderisi, Silvana
TI Factors influencing the outcome of integrated therapy approach in
   schizophrenia: A narrative review of the literature
SO FRONTIERS IN PSYCHIATRY
LA English
DT Review
DE antipsychotics; psychosocial interventions; side effects; treatment
   adherence; cognitive impairment; negative symptoms
ID FACTORS INFLUENCING ADHERENCE; PERSISTENT NEGATIVE SYMPTOMS; CONSENSUS
   COGNITIVE BATTERY; WORKING-MEMORY DEFICITS; CONTEXT-RELATED FACTORS;
   MEDICATION ADHERENCE; 1ST EPISODE; METABOLIC SYNDROME; ANTIPSYCHOTIC
   TREATMENT; FOLLOW-UP
AB The integration of pharmacotherapy with psychosocial interventions has an important role to play in the improvement of functional outcome of subjects with schizophrenia (SCZ), in all stages of the disorder. It is essential for the adequate management of unmet therapeutic needs, such as negative symptoms and cognitive dysfunctions which account for most of the functional impairment of subjects with SCZ and do not respond to available antipsychotics. Enhancing the knowledge on factors involved in the effectiveness of integrated treatment plans is an important step forward for SCZ care. This review aims to identify factors that might influence the impact of integrated treatments on functional outcome. Most studies on the impact of psychosocial treatments on functional outcome of subjects with SCZ did not control for the effect of prescribed antipsychotics or concomitant medications. However, several factors relevant to ongoing pharmacological treatment might influence the outcome of integrated therapy, with an impact on the adherence to treatment (e.g., therapeutic alliance and polypharmacotherapy) or on illness-related factors addressed by the psychosocial interventions (e.g., cognitive dysfunctions or motivational deficits). Indirect evidence suggests that treatment integration should consider the possible detrimental effects of different antipsychotics or concomitant medications on cognitive functions, as well as on secondary negative symptoms. Cognitive dysfunctions can interfere with participation to an integrated treatment plan and can be worsened by extrapyramidal or metabolic side effects of antipsychotics, or concomitant treatment with anticholinergics or benzodiazepines. Secondary negative symptoms, due to positive symptoms, sedation, extrapyramidal side effects or untreated depression, might cause early drop-out and poor adherence to treatment. Researchers and clinicians should examine all the above-mentioned factors and implement appropriate and personalized integrated treatments to improve the outcome of SCZ.
C1 [Giordano, Giulia M. M.; Brando, Francesco; Pezzella, Pasquale; Angelis, Maria De; Mucci, Armida; Galderisi, Silvana] Univ Campania Luigi Vanvitelli, Naples, Italy.
C3 Universita della Campania Vanvitelli
RP Mucci, A (corresponding author), Univ Campania Luigi Vanvitelli, Naples, Italy.
EM armida.mucci@gmail.com
RI Brando, Francesco/LRT-4071-2024; De Angelis, Maria/AAA-9909-2019; Mucci,
   Armida/ABF-2121-2021; Pezzella, Pasquale/GSI-8286-2022; Giordano, Giulia
   Maria/GRJ-8082-2022
OI Giordano, Giulia Maria/0000-0002-5247-1117; Pezzella,
   Pasquale/0000-0002-8442-5385; Brando, Francesco/0009-0003-1229-953X
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NR 274
TC 16
Z9 16
U1 1
U2 8
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-0640
J9 FRONT PSYCHIATRY
JI Front. Psychiatry
PD AUG 30
PY 2022
VL 13
AR 970210
DI 10.3389/fpsyt.2022.970210
PG 17
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 4O0YQ
UT WOS:000854435300001
PM 36117655
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Vaez, A
   Jansen, R
   Prins, BP
   Hottenga, JJ
   de Geus, EJC
   Boomsma, DI
   Penninx, BWJH
   Nolte, IM
   Snieder, H
   Alizadeh, BZ
AF Vaez, Ahmad
   Jansen, Rick
   Prins, Bram P.
   Hottenga, Jouke-Jan
   de Geus, Eco J. C.
   Boomsma, Dorret I.
   Penninx, Brenda W. J. H.
   Nolte, Ilja M.
   Snieder, Harold
   Alizadeh, Behrooz Z.
TI In Silico Post Genome-Wide Association Studies Analysis of C-Reactive
   Protein Loci Suggests an Important Role for Interferons
SO CIRCULATION-CARDIOVASCULAR GENETICS
LA English
DT Article
DE C-reactive protein; genome wide association study; interferon
ID GENETIC-DETERMINANTS; METABOLIC-SYNDROME; RISK-FACTORS; INTERLEUKIN-6;
   INFLAMMATION; CHOLESTEROL; VARIABILITY; DEPRESSION; EXPRESSION;
   PREDICTION
AB Background Genome-wide association studies (GWASs) have successfully identified several single nucleotide polymorphisms (SNPs) associated with serum levels of C-reactive protein (CRP). An important limitation of GWASs is that the identified variants merely flag the nearby genomic region and do not necessarily provide a direct link to the biological mechanisms underlying their corresponding phenotype. Here we apply a bioinformatics-based approach to uncover the functional characteristics of the 18 SNPs that had previously been associated with CRP at a genome-wide significant level.
   Methods and Results In the first phase of in silico sequencing, we explore the vicinity of GWAS SNPs to identify all linked variants. In the second phase of expression quantitative trait loci analysis, we attempt to identify all nearby genes whose expression levels are associated with the corresponding GWAS SNPs. These 2 phases generate several relevant genes that serve as input to the next phase of functional network analysis. Our in silico sequencing analysis using 1000 Genomes Project data identified 7 nonsynonymous SNPs, which are in moderate to high linkage disequilibrium (r(2)>0.5) with the GWAS SNPs. Our expression quantitative trait loci analysis, which was based on one of the largest single data sets of genome-wide expression probes (n>5000) identified 23 significantly associated expression probes belonging to 15 genes (false discovery rate <0.01). The final phase of functional network analysis revealed 93 significantly enriched biological processes (false discovery rate <0.01).
   Conclusions Our post-GWAS analysis of CRP GWAS SNPs confirmed the previously known overlap between CRP and lipids biology. Additionally, it suggested an important role for interferons in the metabolism of CRP.
C1 [Vaez, Ahmad; Prins, Bram P.; Nolte, Ilja M.; Snieder, Harold; Alizadeh, Behrooz Z.] Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, NL-9713 GZ Groningen, Netherlands.
   [Jansen, Rick; Penninx, Brenda W. J. H.] Vrije Univ Amsterdam, Dept Psychiat, Med Ctr, Amsterdam, Netherlands.
   [Jansen, Rick; Hottenga, Jouke-Jan; de Geus, Eco J. C.; Boomsma, Dorret I.; Penninx, Brenda W. J. H.] Vrije Univ Amsterdam, Amsterdam, Netherlands.
   [Jansen, Rick; Hottenga, Jouke-Jan; de Geus, Eco J. C.; Boomsma, Dorret I.; Penninx, Brenda W. J. H.] Vrije Univ Amsterdam, Med Ctr, Amsterdam, Netherlands.
   [Hottenga, Jouke-Jan; de Geus, Eco J. C.; Boomsma, Dorret I.; Penninx, Brenda W. J. H.] Vrije Univ Amsterdam, EMGO Inst, Amsterdam, Netherlands.
   [Hottenga, Jouke-Jan; de Geus, Eco J. C.; Boomsma, Dorret I.] Vrije Univ Amsterdam, Dept Biol Psychol, Amsterdam, Netherlands.
   [Vaez, Ahmad] Isfahan Univ Med Sci, Sch Med, Esfahan, Iran.
C3 University of Groningen; Vrije Universiteit Amsterdam; Vrije
   Universiteit Amsterdam; Vrije Universiteit Amsterdam; Vrije Universiteit
   Amsterdam; Vrije Universiteit Amsterdam; Isfahan University of Medical
   Sciences
RP Alizadeh, BZ (corresponding author), Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, Hanzepl 1, NL-9713 GZ Groningen, Netherlands.
EM a.vaez@umcg.nl; b.z.alizadeh@umcg.nl
RI Boomsma, Dorret/AAX-4470-2020; Penninx, Brenda/S-7627-2017; Vaez,
   Ahmad/B-4336-2018; Jansen, Ritsert/C-1160-2013; de Geus,
   Eco/M-9318-2015; Alizadeh, Behrooz Z./J-2921-2017
OI Jansen, Rick/0000-0002-3333-6737; Vaez, Ahmad/0000-0001-9048-3795; de
   Geus, Eco/0000-0001-6022-2666; Boomsma, Dorret/0000-0002-7099-7972;
   Alizadeh, Behrooz Z./0000-0002-1415-8007; Prins,
   Bram/0000-0001-5774-034X
FU Netherlands Organization for Scientific Research (MagW/ZonMW)
   [904-61-090, 985-10-002, 904-61-193, 480-04-004, 400-05-717, 912-100-20,
   56-464-14192, 10-000-1002]; Center for Medical Systems Biology (NWO
   Genomics), Biobanking and Biomolecular Resources Research
   Infrastructure, VU University's Institutes for Health and Care Research
   and Neuroscience Campus Amsterdam, NBIC/BioAssist/RK [2008.024];
   European Science Foundation [EU/QLRT-2001-01254]; European Community's
   Seventh Framework Program (FP7); ENGAGE [HEALTH-F4-2007-201413];
   European Science Council (ERC) [230374]; US National Institute of Mental
   Health [RC2 MH089951]; Neuroscience Campus Amsterdam; NWO-VICI
   [91811602]; ZonMW Middelgroot [911-09-032]
FX The Netherlands Study of Depression and Anxiety (NESDA) and the
   Netherlands Twin Register (NTR) were funded by the Netherlands
   Organization for Scientific Research (MagW/ZonMW grants 904-61-090,
   985-10-002, 904-61-193, 480-04-004, 400-05-717, 912-100-20;
   Spinozapremie 56-464-14192; Geestkracht program grant 10-000-1002); the
   Center for Medical Systems Biology (NWO Genomics), Biobanking and
   Biomolecular Resources Research Infrastructure, VU University's
   Institutes for Health and Care Research and Neuroscience Campus
   Amsterdam, NBIC/BioAssist/RK (2008.024); the European Science Foundation
   (EU/QLRT-2001-01254); the European Community's Seventh Framework Program
   (FP7/2007-2013); ENGAGE (HEALTH-F4-2007-201413); and the European
   Science Council (ERC, 230374). Gene-expression data were funded by the
   US National Institute of Mental Health (RC2 MH089951) as part of the
   American Recovery and Reinvestment Act of 2009. NESDA and NTR were
   further supported by funding from the Neuroscience Campus Amsterdam and
   through a NWO-VICI grant (number 91811602) and funding from ZonMW
   Middelgroot (911-09-032).
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NR 67
TC 23
Z9 23
U1 0
U2 13
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1942-325X
EI 1942-3268
J9 CIRC-CARDIOVASC GENE
JI Circ.-Cardiovasc. Genet.
PD JUN
PY 2015
VL 8
IS 3
BP 487
EP 497
DI 10.1161/CIRCGENETICS.114.000714
PG 11
WC Cardiac & Cardiovascular Systems; Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Genetics & Heredity
GA CK7NI
UT WOS:000356418800009
PM 25752597
OA Green Published
DA 2025-06-11
ER

PT J
AU Förster, CY
   Shityakov, S
   Scheper, V
   Lenarz, T
AF Foerster, Carola Y.
   Shityakov, Sergey
   Scheper, Verena
   Lenarz, Thomas
TI Linking Cerebrovascular Dysfunction to Age-Related Hearing Loss and
   Alzheimer's Disease-Are Systemic Approaches for Diagnosis and Therapy
   Required?
SO BIOMOLECULES
LA English
DT Review
DE Alzheimer's disease; age-related hearing loss; neurovasculature;
   blood-brain barrier; blood-labyrinth barrier; spiral ganglion neuron;
   pharmacotherapy; neurotrophic factor; inner ear
ID BLOOD-BRAIN-BARRIER; AMYLOID-BETA PEPTIDE; COGNITIVE IMPAIRMENT;
   METABOLIC SYNDROME; NEUROVASCULAR MECHANISMS; CAROTID ATHEROSCLEROSIS;
   CEREBRAL HYPOPERFUSION; ELECTRICAL-STIMULATION; DIABETIC-RETINOPATHY;
   MOLECULAR-DYNAMICS
AB Alzheimer's disease (AD), the most common cause of dementia in the elderly, is a neurodegenerative disorder associated with neurovascular dysfunction, cognitive decline, and the accumulation of amyloid beta peptide (A beta) in the brain and tau-related lesions in neurons termed neurofibrillary tangles (NFTs). A beta deposits and NFT formation are the central pathological hallmarks in AD brains, and the majority of AD cases have been shown to exhibit a complex combination of systemic comorbidities. While AD is the foremost common cause of dementia in the elderly, age-related hearing loss (ARHL) is the most predominant sensory deficit in the elderly. During aging, chronic inflammation and resulting endothelial dysfunction have been described and might be key contributors to AD; we discuss an intriguing possible link between inner ear strial microvascular pathology and blood-brain barrier pathology and present ARHL as a potentially modifiable and treatable risk factor for AD development. We present compelling evidence that ARHL might well be seen as an important risk factor in AD development: progressive hearing impairment, leading to social isolation, and its comorbidities, such as frailty, falls, and late-onset depression, link ARHL with cognitive decline and increased risk of dementia, rendering it tempting to speculate that ARHL might be a potential common molecular and pathological trigger for AD. Additionally, one could speculate that amyloid-beta might damage the blood-labyrinth barrier as it does to the blood-brain barrier, leading to ARHL pathology. Finally, there are options for the treatment of ARHL by targeted neurotrophic factor supplementation to the cochlea to improve cognitive outcomes; they can also prevent AD development and AD-related comorbidity in the future.
C1 [Foerster, Carola Y.; Shityakov, Sergey] Univ Wurzburg, Dept Anaesthesiol Intens Care Emergency & Pain Me, D-97070 Wurzburg, Germany.
   [Shityakov, Sergey] ITMO Univ, Infochem Sci Ctr, Lab Chemoinformat, St Petersburg 197101, Russia.
   [Scheper, Verena; Lenarz, Thomas] Hannover Med Sch, Dept Otorhinolaryngol, D-30625 Hannover, Germany.
   [Scheper, Verena; Lenarz, Thomas] Cluster Excellence Hearing4All, D-30625 Hannover, Germany.
C3 University of Wurzburg; ITMO University; Hannover Medical School
RP Förster, CY (corresponding author), Univ Wurzburg, Dept Anaesthesiol Intens Care Emergency & Pain Me, D-97070 Wurzburg, Germany.; Lenarz, T (corresponding author), Hannover Med Sch, Dept Otorhinolaryngol, D-30625 Hannover, Germany.; Lenarz, T (corresponding author), Cluster Excellence Hearing4All, D-30625 Hannover, Germany.
EM foerster_c@ukw.de; lenarz.thomas@mh-hannover.de
RI Shityakov, Sergey/H-3322-2019; Scheper, Verena/J-4298-2019
OI Scheper, Verena/0000-0001-8618-8793; Forster,
   Carola/0000-0002-3878-247X; Lenarz, Thomas/0000-0002-9307-5989;
   Shityakov, Sergey/0000-0002-6953-9771
FU Deutsche Forschungsgemeinschaft;  [DFG_FO 315-5-1]
FX This work was supported by the grant DFG_FO 315-5-1 from Deutsche
   Forschungsgemeinschaft to C.F. Special thanks are extended to Todd Axel
   Johnsen from the Infochemistry Scientific Centre, ITMO University, for
   his assistance in editing and proofreading the manuscript.
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NR 146
TC 11
Z9 12
U1 2
U2 10
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2218-273X
J9 BIOMOLECULES
JI Biomolecules
PD NOV
PY 2022
VL 12
IS 11
AR 1717
DI 10.3390/biom12111717
PG 20
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 6U8CJ
UT WOS:000894589800001
PM 36421731
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Wojciechowska-Zdrojowy, M
   Reid, A
   Szepietowski, JC
   Wojciechowski, A
AF Wojciechowska-Zdrojowy, Marta
   Reid, Adam
   Szepietowski, Jacek C.
   Wojciechowski, Adam
TI Analysis of Sexual Problems in Men With Psoriasis
SO JOURNAL OF SEX & MARITAL THERAPY
LA English
DT Article
ID ERECTILE FUNCTION IIEF-5; INTERNATIONAL INDEX; DIAGNOSTIC-TOOL;
   DYSFUNCTION; LIFE; POPULATION; PREVALENCE
AB Psoriasis may have a negative impact on many aspects of patient life. The aim of the study was to evaluate the influence of psoriasis on erectile dysfunction and other sexual problems in men with psoriasis. A total of 76 men aged between 20 and 66 years (mean 43.9 +/- 13.2 years) were enrolled. Psoriasis severity assessed according to the Psoriasis Area and Severity Index (PASI) ranged from 2.0 to 49.8 points (mean 15.1 +/- 10.3 points). All patients were asked to complete the International Index of Erectile Function, the Beck Depression Inventory (BDI), and the Dermatology Life Quality Index. A detailed medical history regarding sexual problems was also collected. Erectile dysfunction was found in 43.8% of patients. The severity of erectile dysfunction negatively correlated with the age of patients (rho = -0.42; p < 0.01) and depressive symptoms assessed by BDI (rho = -0.39, p < 0.01). The majority of patients (77.6%) declared that the skin condition at least occasionally negatively influenced their sexual life. Patients with more severe psoriasis more often avoided sexual intercourse (p < 0.01) and felt ashamed in front of their sexual partners (p = 0.04). The vast majority of men (96.1%) felt unattractive during psoriasis exacerbation and felt embarrassed if skin lesions were present on uncovered body regions. More than half avoided social activities and sexual intercourse due to psoriasis. Moreover, 44.7% experienced rejection during their life because of psoriasis. Psoriasis negatively influences mostly emotional aspects of sexual life. Psychological disturbances, severity of the disease, smoking, metabolic syndrome, and other concomitant diseases might influence the presence and progression of erectile dysfunction in psoriatic patients. Dermatologists should be aware of these problems to put more attention on this aspect of psoriasis.
C1 [Wojciechowska-Zdrojowy, Marta; Szepietowski, Jacek C.] Wroclaw Med Univ, Dept Dermatol Venereol & Allergol, Wroclaw, Poland.
   [Reid, Adam] Univ Rzeszow, Dept Dermatol, Ul Szopena 2, PL-35055 Rzeszow, Poland.
   [Wojciechowski, Adam] Lower Silesian Oncol Ctr, Dept Surg Oncol, Wroclaw, Poland.
C3 Wroclaw Medical University; University of Rzeszow
RP Reid, A (corresponding author), Univ Rzeszow, Dept Dermatol, Ul Szopena 2, PL-35055 Rzeszow, Poland.
EM adi_medicalis@go2.pl
OI Szepietowski, Jacek/0000-0003-0766-6342; Reich, Adam/0000-0002-5573-1754
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NR 27
TC 18
Z9 19
U1 0
U2 3
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 0092-623X
EI 1521-0715
J9 J SEX MARITAL THER
JI J. Sex Marital Ther.
PD NOV 17
PY 2018
VL 44
IS 8
BP 737
EP 745
DI 10.1080/0092623X.2018.1462276
PG 9
WC Psychology, Clinical; Family Studies
WE Social Science Citation Index (SSCI)
SC Psychology; Family Studies
GA IE1CA
UT WOS:000472122300002
PM 29648989
DA 2025-06-11
ER

PT J
AU Cullen, T
   Thomas, AW
   Webb, R
   Hughes, MG
AF Cullen, T.
   Thomas, A. W.
   Webb, R.
   Hughes, M. G.
TI The relationship between interleukin-6 in saliva, venous and capillary
   plasma, at rest and in response to exercise
SO CYTOKINE
LA English
DT Article
DE Interluekin-6; Cytokines; Exercise; Capillary; Saliva
ID IL-6; INTENSITY; MUSCLES; SERUM
AB IL-6 plays a mechanistic role in conditions such as metabolic syndrome, chronic fatigue syndrome and clinical depression and also plays a major role in inflammatory and immune responses to exercise. The purpose of this study was to investigate the levels of resting and post exercise IL-6 when measured in venous plasma, saliva and capillary plasma. Five male and five females completed 2 separate exercise trials, both of which involved standardized exercise sessions on a cycle ergometer. Venous blood and saliva samples were taken immediately before and after Trial A, venous and capillary blood samples were taken immediately before and after Trial B. IL-6 values were obtained using a high-sensitivity enzyme-linked immunosorbent assay (ELISA). In Trial A venous plasma IL-6 increased significantly from 0.4 +/- 0.14 pg/ml to 0.99 +/- 0.29 pg/ml (P < 0.01) while there was no increase in salivary IL-6. Venous plasma and salivary IL-6 responses were not correlated at rest, post exercise or when expressed as an exercise induced change. In Trial B venous and capillary plasma IL-6 increased significantly (venous: 0.22 +/- 0.18 to 0.74 +/- 0.28 pg/ml (P 0.01); capillary: 0.37 +/- 0.22 to 1.08 +/- 0.30 pg/ml (P < 0.01). Venous and capillary plasma responses did not correlate at rest (r = 0.59, P = 0.07) but did correlate post exercise (r = 0.79, P >= 0.001) and when expressed as an exercise induced change (r = 0.71, P = 0.02). Saliva does not appear to reflect systemic IL-6 responses, either at rest or in response to exercise. Conversely, capillary plasma responses are reflective of systemic IL-6 responses to exercise. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Cullen, T.; Hughes, M. G.] Cardiff Metropolitan Univ, Cardiff Sch Sport, Cardiff CF23 6XD, S Glam, Wales.
   [Thomas, A. W.; Webb, R.] Cardiff Metropolitan Univ, Cardiff Sch Hlth Sci, Cardiff CF5 2YB, S Glam, Wales.
C3 Cardiff Metropolitan University; Cardiff Metropolitan University;
   Cardiff University
RP Cullen, T (corresponding author), Cardiff Metropolitan Univ, Cardiff Sch Sport, Cardiff CF23 6XD, S Glam, Wales.
EM tcullen@cardiffmet.ac.uk
RI Cullen, Tom/AAY-6162-2021; Hughes, Michael/AAV-1966-2020
OI Cullen, Tom/0000-0002-9058-6716
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NR 15
TC 37
Z9 45
U1 0
U2 12
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 1043-4666
EI 1096-0023
J9 CYTOKINE
JI Cytokine
PD FEB
PY 2015
VL 71
IS 2
BP 397
EP 400
DI 10.1016/j.cyto.2014.10.011
PG 4
WC Biochemistry & Molecular Biology; Cell Biology; Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology; Immunology
GA CA6YJ
UT WOS:000349063500038
PM 25464926
OA Green Accepted, Green Submitted
DA 2025-06-11
ER

PT J
AU Brevetti, G
   Giugliano, G
   Oliva, G
   Lanero, S
   De Maio, JI
   Chiariello, M
AF Brevetti, G.
   Giugliano, G.
   Oliva, G.
   Lanero, S.
   De Maio, J. I.
   Chiariello, M.
TI The impact of comorbidity burden on the cardiovascular risk in the
   Peripheral Arteriopathy and Cardiovascular Events study
SO QJM-AN INTERNATIONAL JOURNAL OF MEDICINE
LA English
DT Article
ID ILLNESS RATING-SCALE; ARTERIAL-DISEASE; GENERAL-POPULATION; METABOLIC
   SYNDROME; CO-MORBIDITY; PREVALENCE; VALIDATION; HEALTH; REHABILITATION;
   DEPRESSION
AB Background: A comprehensive evaluation of comorbidity is important in predicting outcome of patients affected by a chronic disease because of the role of competing risk.
   Aim: To assess the prognostic impact of the Cumulative Illness Rating Scale (CIRS) on the cardiovascular risk of subjects participating in the Peripheral Arteriopathy and Cardiovascular Events (PACE) study.
   Design: Prospective study.
   Methods: The study included 60 patients with peripheral arterial disease (PAD) and 163 no-PAD subjects. CIRS-illness severity (IS) score and CIRS-comorbidity index (CI) were calculated.
   Results: After a 42-month follow-up, 18/223 participants had a myocardial infarction or stroke. These subjects had a higher CIRS-IS score (1.99 +/- 0.52 vs. 1.71 +/- 0.37, P= 0.003) and a higher CIRS-CI (4.00 +/- 2.81 vs. 2.65 +/- 1.85, P= 0.005) vs. the 205 subjects without event. However, the significant association of CIRS scores with the outcome disappeared when conditions considered to be concordant with the endpoint were excluded from the calculation of the scores. Importantly, among the 163 no-PAD subjects CIRS scores did not differ between those with and without an event. Conversely, in the 60 PAD patients, the CIRS-IS score calculated excluding the concordant conditions was associated with an increased cardiovascular risk (RR=4.03, 95 confidence interval (CI) 1.05-15.37, P=0.042) after adjustment for potential confounders. The corresponding RR for the CIRS-CI was 1.43 (95% CI 1.03-1.98, P=0.032). Furthermore, both CIRS scores improved the predictive value of ankle/brachial index, which is the most powerful prognostic indicator in PAD.
   Conclusions: Our findings indicate that overall comorbidity, and not only cardiovascular comorbidity, must be considered for prediction of myocardial infarction and stroke in PAD.
C1 [Brevetti, G.; Giugliano, G.; Oliva, G.; Lanero, S.; De Maio, J. I.; Chiariello, M.] Univ Naples Federico 2, Dept Clin Med & Cardiovasc & Immunol Sci, Naples, Italy.
C3 University of Naples Federico II
RP Brevetti, G (corresponding author), Via G Iannelli 45-A, I-80131 Naples, Italy.
EM brevetti@unina.it
RI Chiariello, Mario/O-3642-2014; Giugliano, Giuseppe/K-1632-2016
OI Giugliano, Giuseppe/0000-0002-1467-1687
CR Albertsen PC, 1996, J UROLOGY, V156, P127, DOI 10.1016/S0022-5347(01)65964-0
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NR 34
TC 5
Z9 5
U1 0
U2 3
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1460-2725
J9 QJM-INT J MED
JI QJM-An Int. J. Med.
PD JUL
PY 2008
VL 101
IS 7
BP 575
EP 582
DI 10.1093/qjmed/hcn056
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 319VC
UT WOS:000257191500010
PM 18463142
DA 2025-06-11
ER

PT J
AU Tsolaki, M
   Lazarou, E
   Kozori, M
   Petridou, N
   Tabakis, I
   Lazarou, I
   Karakota, M
   Saoulidis, I
   Melliou, E
   Magiatis, P
AF Tsolaki, Magda
   Lazarou, Eftychia
   Kozori, Mahi
   Petridou, Niki
   Tabakis, Irene
   Lazarou, Ioulietta
   Karakota, Maria
   Saoulidis, Iordanis
   Melliou, Eleni
   Magiatis, Prokopios
TI A Randomized Clinical Trial of Greek High Phenolic Early Harvest Extra
   Virgin Olive Oil in Mild Cognitive Impairment: The MICOIL Pilot Study
SO JOURNAL OF ALZHEIMERS DISEASE
LA English
DT Article
DE Alzheimer's disease; APOE; extra virgin olive oil; Mediterranean Diet;
   mild cognitive impairment; natural compounds; non-pharmaceutical
   interventions
ID DISEASE ASSESSMENT SCALE; ALZHEIMERS-DISEASE; MEDITERRANEAN DIET;
   NEUROPSYCHIATRIC INVENTORY; METABOLIC SYNDROME; VALIDATION; DEPRESSION;
   DEMENTIA; EFFICACY; DECLINE
AB Background: Extra virgin olive oil (EVOO) constitutes a natural compound with high protection over cognitive function.
   Objective: To investigate for the first time the effect of Greek High Phenolic Early Harvest Extra Virgin Olive Oil (HP-EHE-VOO) versus Moderate Phenolic (MP-EVOO) and Mediterranean Diet (MeDi) in people with mild cognitive impairment (MCI).
   Methods: We conducted a randomized prospective study so as to examine the HP-EH-EVOO and MP-EVOO versus MeDi in MCI. Genetic predisposition (APOE epsilon 4) to Alzheimer's disease (AD) was tested and an extensive neuropsychological battery was administered at baseline and after 12 months. Each participant was randomized and assigned one of three groups: 1) Group 1 received the HP-EH-EVOO (50 mL/day); 2) Group 2 received the MP-EVOO (50 mL/day), and 3) Group 3 received only the MeDi instructions.
   Results: Better follow-up performance was found in Group 1 compared to Group 2 and Group 3 in the almost all cognitive domains. Moreover, Group 2 showed also significant improvement compared to Group 3 in ADAS-cog (p = 0 .001) and MMSE (p = 0.05), whereas Group 3 exhibited worse or similar to baseline performance in almost all domains. In particular, Group 1 and Group 2 had better outcomes with regards to ADAS-cog (p = 0.003), Digit Span (p = 0.006), and Letter fluency (p = 0.003). Moreover, there was a significant difference (p = 0.001) in the presence of APOE epsilon 4 between the Groups 1 and 2 versus Group 3.
   Conclusion: Long-term intervention with HP-EH-EVOO or MP-EVOO was associated with significant improvement in cognitive function compared to MeDi, independent of the presence of APOE epsilon 4.
C1 [Tsolaki, Magda; Tabakis, Irene; Lazarou, Ioulietta; Saoulidis, Iordanis] Aristotle Univ Thessaloniki, Gen Univ Hopsital AHEPA, Fac Hlth Sci, Med Sch,Dept Neurol, Macedonia, Greece.
   [Tsolaki, Magda; Lazarou, Eftychia; Kozori, Mahi; Petridou, Niki; Karakota, Maria] Greek Assoc Alzheimers Dis & Related Disorders, Thessaloniki, Makedonia, Greece.
   [Melliou, Eleni; Magiatis, Prokopios] Natl & Kapodistrian Univ Athens, Fac Pharm, Dept Pharmacognosy & Nat Prod Chem, Athens, Greece.
C3 Aristotle University of Thessaloniki; National & Kapodistrian University
   of Athens
RP Tsolaki, M (corresponding author), Aristotle Univ Thessaloniki, Fac Hlth Sci, Med Sch, Dept Neurol GUH AHEPA 1, Thessaloniki, Greece.
EM tsolakim1@gmail.com
RI MAGIATIS, Prokopios/A-2008-2008
OI Tsolaki, Magda/0000-0002-2072-8010; Tabakis,
   Irene-Maria/0009-0008-1509-7016; Kozori, Mahi/0000-0002-3226-5922;
   Lazarou, Ioulietta/0000-0001-5113-8366
FU Greek Association of Alzheimer's Disease and Related Disorders (GAADRD);
   World Olive Centre for Health (WOCH); Yanni's Olive Grove company
FX This work has been supported by the Greek Association of Alzheimer's
   Disease and Related Disorders (GAADRD), the World Olive Centre for
   Health (WOCH) and Yanni's Olive Grove company for the donation of
   HP-EH-EVOO: Yanni's Fresh and MPEVOO: Yanni's Selected. In addition, we
   would like to thank Panagiotis Diamantakos and Aimilia Riga kou for
   technical support in the analysis of EVOO, Hadar Halivni for editing the
   English language, and all clinicians who contributed to this study, as
   well as patients who took part in it.
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NR 60
TC 53
Z9 54
U1 1
U2 17
PU IOS PRESS
PI AMSTERDAM
PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS
SN 1387-2877
EI 1875-8908
J9 J ALZHEIMERS DIS
JI J. Alzheimers Dis.
PY 2020
VL 78
IS 2
BP 801
EP 817
DI 10.3233/JAD-200405
PG 17
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology
GA OV5KH
UT WOS:000592248100026
PM 33044178
DA 2025-06-11
ER

PT J
AU Sommer, IE
   Gangadin, SS
   de Witte, LD
   Koops, S
   van Baal, C
   Bahn, S
   Drexhage, H
   van Haren, NEM
   Veling, W
   Bruggeman, R
   Martens, P
   Wiersma, S
   Veerman, SRT
   Grootens, KP
   van Beveren, N
   Kahn, RS
   Begemann, MJH
AF Sommer, Iris E.
   Gangadin, Shiral S.
   de Witte, Lot D.
   Koops, Sanne
   van Baal, C.
   Bahn, Sabine
   Drexhage, Hemmo
   van Haren, N. E. M.
   Veling, Wim
   Bruggeman, R.
   Martens, Peter
   Wiersma, Sybren
   Veerman, Selene R. T.
   Grootens, Koen P.
   van Beveren, Nico
   Kahn, Rene S.
   Begemann, Marieke J. H.
TI Simvastatin Augmentation for Patients With Early-Phase
   Schizophrenia-Spectrum Disorders: A Double-Blind, Randomized
   Placebo-Controlled Trial
SO SCHIZOPHRENIA BULLETIN
LA English
DT Article
DE schizophrenia; symptoms; simvastatin; inflammation; RCT
ID ADJUNCTIVE THERAPY; NEGATIVE SYMPTOMS; RATING-SCALE; RELIABILITY;
   PSYCHOSIS; METAANALYSIS; PREVENTION; COGNITION; STATINS
AB Schizophrenia-spectrum disorders (SSD) are associated with increased inflammatory markers, both in brain and periphery. Augmentation with drugs that lower this proinflammatory status may improve clinical presentation. +imvastatin crosses the blood-brain barrier, has anti-inflammatory and neuroprotective effects and reduces metabolic s:+ ndrome. In this study, we investigated if 12 months of simvastatin augmentation can improve symptoms and cognition in patients with early SSD. This double-blind placebo-controlled trial included 127 SSD patients across the Netherlands, <3 years after their diagnosis. From these, 119 were randomly assigned 1:1 to simvastatin 40 mg (n = 61) or placebo (n = 58), stratified for sex and study site. Primary outcomes were symptom severity and cognition after 12 months of treatment. Depression, symptom subscores, general functioning, metabolic syndrome, movement disorders, and safety were secondary outcomes. Intention to treat analyses were performed using linear mixed models and ANCOVA. No main effect of simvastatin treatment was found on total symptom severity after 12 months of treatment as compared to placebo (X-2(1) = 0.01, P = .90). Group differences varied over time (treatment*time X-2(4) = 11.2; P = .025), with significantly lower symptom severity in the simvastatin group after 6 months (mean difference = -4.8; P = .021; 95% CI: -8.8 to -0.7) and at 24 months follow-up (mean difference = -4.7; P = .040; 95% CI: -9.3 to -0.2). No main treatment effect was found for cognition (F(1,0.1) = 0.37, P = .55) or secondary outcomes. SAEs occurred more frequently with placebo (19%) than with simvastatin (6.6%). This negative finding corroborates other large scale studies on aspirin, minocycline, and celecoxib that could not replicate positive findings of smaller studies, and suggests that anti-inflammatory augmentation does not improve the clinical presentation of SSD.
C1 [Sommer, Iris E.; Gangadin, Shiral S.; Koops, Sanne; Begemann, Marieke J. H.] Univ Groningen, Univ Med Ctr Groningen UMCG, Dept Biomed Sci Cells & Syst, Groningen, Netherlands.
   [Sommer, Iris E.; Veling, Wim; Bruggeman, R.] Univ Groningen, Univ Med Ctr Groningen, Dept Psychiat, Groningen, Netherlands.
   [de Witte, Lot D.; Kahn, Rene S.] Icahn Sch Med Mt Sinai, Dept Psychiat, New York, NY 10029 USA.
   [van Baal, C.] Univ Med Ctr Utrecht, Julius Ctr, Dept Biostat & Res Support, Utrecht, Netherlands.
   [Bahn, Sabine] Univ Cambridge, Dept Chem Engn & Biotechnol, Cambridge, England.
   [Drexhage, Hemmo] Erasmus MC, Dept Immunol Res, Rotterdam, Netherlands.
   [van Haren, N. E. M.] Erasmus MC, Dept Child Psychiat, Rotterdam, Netherlands.
   [Martens, Peter; Grootens, Koen P.] Reinier van Arkel Inst Mental Hlth Care, Shertogenbosch, Netherlands.
   [Wiersma, Sybren] GGZ InGeest Specialized Mental Hlth Care, Early Intervent Psychosis Team, Hoofddorp, Netherlands.
   [Veerman, Selene R. T.] Mental Hlth Serv Noord Holland Noord, Community Mental Hlth, Alkmaar, Netherlands.
   [van Beveren, Nico] Erasmus MC, Dept Neurosci, Antes Ctr Mental Hlth Care, Rotterdam, Netherlands.
   [van Beveren, Nico] Erasmus MC, Dept Psychiat, Rotterdam, Netherlands.
   [Kahn, Rene S.] Univ Med Ctr Utrecht, Dept Psychiat, Utrecht, Netherlands.
C3 University of Groningen; University of Groningen; Icahn School of
   Medicine at Mount Sinai; Utrecht University; Utrecht University Medical
   Center; University of Cambridge; Erasmus University Rotterdam; Erasmus
   MC; Erasmus University Rotterdam; Erasmus MC; Erasmus University
   Rotterdam; Erasmus MC; Erasmus University Rotterdam; Erasmus MC; Utrecht
   University; Utrecht University Medical Center
RP Sommer, IE (corresponding author), Univ Groningen, Univ Med Ctr Groningen UMCG, Dept Biomed Sci Cells & Syst, Groningen, Netherlands.
EM i.e.c.sommer@umcg.nl
RI sommer, iris/D-1190-2014; van Os, Jim/I-9496-2012; van Haren,
   Neeltje/AAC-7656-2020; Veerman, S./I-5011-2019; de Witte,
   Lot/GZG-9717-2022
OI Sommer, Iris/0000-0001-5597-3262; DE WITTE, LOTJE/0000-0002-7235-9958;
   Veerman, Selene/0000-0002-7604-6529; Veling, Wim/0000-0002-1364-9779;
   Gangadin, Shiral/0000-0002-0084-8226
FU Stanley Medical Research Institute [12T-008]; Dutch Research Council
   (NWO) [40-00812-98-12154]
FX This work was supported by the Stanley Medical Research Institute (grant
   number: 12T-008) and the Dutch Research Council (NWO; grant number:
   40-00812-98-12154). The sponsors were not involved in the collection,
   analysis and interpretation of data, nor in writing of the report and
   the decision to submit the paper for publication.
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NR 45
TC 26
Z9 28
U1 3
U2 4
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0586-7614
EI 1745-1701
J9 SCHIZOPHRENIA BULL
JI Schizophr. Bull.
PD JUL
PY 2021
VL 47
IS 4
BP 1108
EP 1115
DI 10.1093/schbul/sbab010
EA FEB 2021
PG 8
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA UA5RU
UT WOS:000685220000028
PM 33608711
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Belury, MA
   Cole, RM
   Bailey, BE
   Ke, JY
   Andridge, RR
   Kiecolt-Glaser, JK
AF Belury, Martha A.
   Cole, Rachel M.
   Bailey, Brittney E.
   Ke, Jia-Yu
   Andridge, Rebecca R.
   Kiecolt-Glaser, Janice K.
TI Erythrocyte linoleic acid, but not oleic acid, is associated with
   improvements in body composition in men and women
SO MOLECULAR NUTRITION & FOOD RESEARCH
LA English
DT Article
DE Body composition; Erythrocyte fatty acid composition; Linoleic acid;
   Unsaturated fatty acids
ID SUPPLEMENTATION LOWERS INFLAMMATION; DIETARY FATTY-ACIDS;
   METABOLIC-RESPONSES; PAST DEPRESSION; SATURATED FAT; OMEGA-3 INDEX;
   MUSCLE MASS; N-3; PLASMA; OIL
AB Scope: Supplementation with linoleic acid (LA; 18: 2 Omega 6)-rich oils increases lean mass and decreases trunk adipose mass in people. Erythrocyte fatty acids reflect the dietary pattern of fatty acid intake and endogenous metabolism of fatty acids. The aim of this study is to determine the relationship of erythrocyte LA, with aspects of body composition, insulin resistance, and inflammation. Additionally, we tested for relationships of oleic acid (OA) and the sum of long chain omega-three fatty acids (LC-Omega 3-SUM), on the same outcomes.
   Methods and results: Men and women (N = 139) were evaluated for body composition, insulin resistance, and serum inflammatory markers, IL-6, and c-reactive protein (CRP) and erythrocyte fatty acid composition after an overnight fast. LA was positively related to appendicular lean mass/body mass index and inversely related to trunk adipose mass. Additionally, LA was inversely related to insulin resistance and IL-6. While there was an inverse relationship between OA or LC-Omega 3-SUM with markers of inflammation, there were no relationships between OA or LC-Omega 3-SUM with body composition or HOMA-IR.
   Conclusion: Higher erythrocyte LA was associated with improved body composition, insulin resistance, and inflammation. Erythrocyte OA or LC-Omega 3-SUM was unrelated to body composition and insulin resistance. There is much controversy about whether all unsaturated fats have the same benefits for metabolic syndrome and weight gain. We sought to test the strength of the relationships between three unsaturated fatty acid in erythrocytes with measurements of body composition, metabolism, and inflammation in healthy adults. Linoleic acid, but not oleic acid or the sum of long-chain omega 3 fatty acids (w3), was associated with increased appendicular lean mass and decreased trunk adipose mass and insulin resistance.
C1 [Belury, Martha A.; Cole, Rachel M.; Ke, Jia-Yu] Ohio State Univ, Dept Human Sci, Program Human Nutr, Coll Educ & Human Ecol, Columbus, OH 43210 USA.
   [Bailey, Brittney E.; Andridge, Rebecca R.] Coll Publ Hlth, Div Biostat, Columbus, OH USA.
   [Bailey, Brittney E.; Kiecolt-Glaser, Janice K.] Ohio State Univ, Coll Med, Dept Psychiat, Inst Behav Med Res, Columbus, OH 43210 USA.
C3 University System of Ohio; Ohio State University; University System of
   Ohio; Ohio State University
RP Belury, MA (corresponding author), Ohio State Univ, Dept Human Sci, Program Human Nutr, Coll Educ & Human Ecol, Columbus, OH 43210 USA.
EM Belury.1@osu.edu
RI Andridge, Rebecca/C-8457-2012
OI Andridge, Rebecca/0000-0001-9991-9647; Bailey, Brittney
   E./0000-0002-6859-2415
FU NIH-NCI [CA154054, CA158868, CA172296, CA186720]
FX This research was supported by NIH-NCI CA154054 (J.K.G.), NIH-NCI
   CA158868 (J.K.-G.), NIH-NCI CA172296 (J.K.-G.), and NIH-NCI CA186720
   (J.K.-G., R.R.A.).
CR [Anonymous], 2014, WHAT WE EAT AM IND 2
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NR 35
TC 46
Z9 49
U1 1
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1613-4125
EI 1613-4133
J9 MOL NUTR FOOD RES
JI Mol. Nutr. Food Res.
PD MAY
PY 2016
VL 60
IS 5
BP 1206
EP 1212
DI 10.1002/mnfr.201500744
PG 7
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA DL8TN
UT WOS:000375914700022
PM 26923704
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Brixner, DI
   Said, Q
   Corey-Lisle, PK
   Tuomari, AV
   L'Italien, GJ
   Stockdale, W
   Oderda, GM
AF Brixner, DI
   Said, Q
   Corey-Lisle, PK
   Tuomari, AV
   L'Italien, GJ
   Stockdale, W
   Oderda, GM
TI Naturalistic impact of second-generation antipsychotics on weight gain
SO ANNALS OF PHARMACOTHERAPY
LA English
DT Article
DE BMI; second-generation antipsychotic agents; weight gain
ID METABOLIC SYNDROME; RISK; OLANZAPINE; DRUGS; SCHIZOPHRENIA; RISPERIDONE;
   POPULATION; DEPRESSION; STIGMA; AGENTS
AB BACKGROUND: While second-generation antipsychotics (SGAs) have had benefits over earlier antipsychotic treatments, their use has been associated with reports of weight gain. Body mass index (BMI) has been studied in clinical trials with limited comparison between drugs.
   OBJECTIVE: To investigate the impact of each SGA on the risk of weight increase in an adult population.
   METHODS: Using a national electronic medical records database, a naturalistic impact of SGAs on BMI was evaluated. Patients (aged >= 18 y) receiving a prescription for an antipsychotic drug between January 1995 and March 2004 were identified. An adverse event was defined as at least a 7% increase in BMI from baseline within one year of antipsychotic prescription and a post-increase BMI of at least 25 kg/m(2). RESULTS: A total of 9394 patients were identified, with 1514 cases of increased BMI after initial prescription. Risperidone (OR 1.39; 95% CI 1.16 to 1.66), quetiapine (OR 1,36; 95% CI 1.13 to 1.64), and olanzapine (OR 1.76; 95% CI 1.50 to 2.07) were significantly more likely to cause BMI increase compared with first-generation antipsychotics (FGAs). Aripiprazole (OR 0.72; 95% CI 0.36 to 1.46), ziprasidone (OR 0.68; 95% CI 0.39 to 1.18), and clozapine (OR 1.01; 95% CI 0.56 to 1.81) were less likely to induce weight gain compared with FGAs.
   CONCLUSIONS: This study provides a foundation for understanding how SGAs impact weight gain in a naturalistic, as opposed to a clinical trial, setting and provides evidence that there are differential risks of weight gain between SGAs. Because of negative longterm health effects of weight gain, physicians need to take all factors into consideration when recommending pharmaceutical therapy for patients with severe mental illness.
C1 Univ Utah, Pharmacotherapy Outcomes Res Ctr, Salt Lake City, UT 84108 USA.
   Univ Utah, Dept Pharmacotherapy, Salt Lake City, UT 84108 USA.
   Univ Utah, Pharmacotherapy Outcomes Res Ctr, Salt Lake City, UT 84112 USA.
   Bristol Myers Squibb Co, Wallingford, CT 06492 USA.
   Bristol Myers Squibb Co, Plainsboro, NJ USA.
C3 Utah System of Higher Education; University of Utah; Utah System of
   Higher Education; University of Utah; Utah System of Higher Education;
   University of Utah; Bristol-Myers Squibb; Bristol-Myers Squibb
RP Univ Utah, Pharmacotherapy Outcomes Res Ctr, 421 Wakara Way,Rm 208, Salt Lake City, UT 84108 USA.
EM dbrixner@hsc.utah.edu
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NR 32
TC 39
Z9 41
U1 0
U2 2
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1060-0280
EI 1542-6270
J9 ANN PHARMACOTHER
JI Ann. Pharmacother.
PD APR
PY 2006
VL 40
IS 4
BP 626
EP 632
DI 10.1345/aph.1G564
PG 7
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 035MR
UT WOS:000237005900005
PM 16569802
DA 2025-06-11
ER

PT J
AU Miola, A
   De Filippis, E
   Veldic, M
   Ho, AMC
   Winham, SJ
   Mendoza, M
   Romo-Nava, F
   Nunez, NA
   Resendez, MG
   Prieto, ML
   McElroy, SL
   Biernacka, JM
   Frye, MA
   Cuellar-Barboza, AB
AF Miola, Alessandro
   De Filippis, Eleanna
   Veldic, Marin
   Ho, Ada Man-Choi
   Winham, Stacey J.
   Mendoza, Mariana
   Romo-Nava, Francisco
   Nunez, Nicolas A.
   Resendez, Manuel Gardea
   Prieto, Miguel L.
   McElroy, Susan L.
   Biernacka, Joanna M.
   Frye, Mark A.
   Cuellar-Barboza, Alfredo B.
TI The genetics of bipolar disorder with obesity and type 2 diabetes
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Review
DE Bipolar disorder; Obesity; Diabetes type 2; Genome-wide association
   study; Genomics; Polygenic risk score
ID GENOME-WIDE ASSOCIATION; BODY-MASS INDEX; INSULIN-RESISTANCE; METABOLIC
   SYNDROME; MEDICAL COMORBIDITY; SKELETAL-MUSCLE; TCF7L2; RISK; WNT;
   MECHANISMS
AB Background: Bipolar disorder (BD) presents with high obesity and type 2 diabetes (T2D) and pathophysiological and phenomenological abnormalities shared with cardiometabolic disorders. Genomic studies may help define if they share genetic liability. This selective review of BD with obesity and T2D will focus on genomic studies, stress their current limitations and guide future steps in developing the field.Methods: We searched electronic databases (PubMed, Scopus) until December 2021 to identify genome-wide association studies, polygenic risk score analyses, and functional genomics of BD accounting for body mass index (BMI), obesity, or T2D.Results: The first genome-wide association studies (GWAS) of BD accounting for obesity found a promising genome-wide association in an intronic gene variant of TCF7L2 that was further replicated. Polygenic risk scores of obesity and T2D have also been associated with BD, yet, no genetic correlations have been demonstrated. Finally, human-induced stem cell studies of the intronic variant in TCF7L2 show a potential biological impact of the products of this genetic variant in BD risk. Limitations: The narrative nature of this review.Conclusions: Findings from BD GWAS accounting for obesity and their functional testing, have prompted potential biological insights. Yet, BD, obesity, and T2D display high phenotypic, genetic, and population-related hetero-geneity, limiting our ability to detect genetic associations. Further studies should refine cardiometabolic phe-notypes, test gene-environmental interactions and add population diversity.
C1 [Miola, Alessandro] Univ Padua, Dept Neurosci DNS, Padua, Italy.
   [De Filippis, Eleanna] Mayo Clin, Dept Endocrinol, Scottsdale, AZ USA.
   [Veldic, Marin; Ho, Ada Man-Choi; Nunez, Nicolas A.; Resendez, Manuel Gardea; Prieto, Miguel L.; Biernacka, Joanna M.; Frye, Mark A.; Cuellar-Barboza, Alfredo B.] Mayo Clin, Dept Psychiat & Psychol, Rochester, MN USA.
   [Winham, Stacey J.; Biernacka, Joanna M.] Mayo Clin, Dept Hlth Sci Res, Rochester, MN USA.
   [Mendoza, Mariana; Cuellar-Barboza, Alfredo B.] Univ Autonoma Nuevo Leon, Dept Psychiat, Monterrey, Mexico.
   [Romo-Nava, Francisco; McElroy, Susan L.] Lindner Ctr HOPE, Mason, OH USA.
   [Romo-Nava, Francisco; McElroy, Susan L.] Univ Cincinnati, Dept Psychiat & Behav Neurosci, Coll Med, Cincinnati, OH USA.
   [Prieto, Miguel L.] Univ Andes, Fac Med, Dept Psychiat, Santiago, Chile.
   [Prieto, Miguel L.] Clin Univ Andes, Mental Hlth Serv, Santiago, Chile.
   [Prieto, Miguel L.] Univ Andes, Ctr Biomed Res & Innovat, Santiago, Chile.
   [Cuellar-Barboza, Alfredo B.] Univ Autonoma Nuevo Leon, Dept Psychiat, Madero & Gonzalitos SN, Monterrey 64460, Mexico.
C3 University of Padua; Mayo Clinic; Mayo Clinic Phoenix; Mayo Clinic; Mayo
   Clinic; Universidad Autonoma de Nuevo Leon; University System of Ohio;
   University of Cincinnati; Universidad de los Andes - Chile; Universidad
   de los Andes - Chile; Universidad de los Andes - Chile; Universidad
   Autonoma de Nuevo Leon
RP Cuellar-Barboza, AB (corresponding author), Univ Autonoma Nuevo Leon, Dept Psychiat, Madero & Gonzalitos SN, Monterrey 64460, Mexico.
EM alfredo.cuellarb@uanl.mx
RI Nunez, Nicolas/HPD-4606-2023; Cuellar-Barboza, Alfredo/A-9278-2015;
   Veldic, Marin/N-7705-2017; Gardea Resendez, Manuel/LZE-8888-2025; Miola,
   Alessandro/LMP-0749-2024
OI Gardea Resendez, Manuel/0000-0002-9825-8792; Ho, Man
   Choi/0000-0003-4989-8782
FU Huang Family;  [T32 GM008685];  [K23MH120503]
FX This work was supported by the generous benefactors: the Huang Family.
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NR 134
TC 10
Z9 10
U1 0
U2 7
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD SEP 15
PY 2022
VL 313
BP 222
EP 231
DI 10.1016/j.jad.2022.06.084
EA JUL 2022
PG 10
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA 5W4JI
UT WOS:000877882000016
PM 35780966
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Adams-Campbell, LL
   Taylor, T
   Hicks, J
   Lu, JC
   Dash, C
AF Adams-Campbell, Lucile L.
   Taylor, Teletia
   Hicks, Jennifer
   Lu, Jiachen
   Dash, Chiranjeev
TI The Effect of a 6-Month Exercise Intervention Trial on Allostatic Load
   in Black Women at Increased Risk for Breast Cancer: the FIERCE Study
SO JOURNAL OF RACIAL AND ETHNIC HEALTH DISPARITIES
LA English
DT Article
DE Allostatic load; Exercise intervention; Breast cancer; Postmenopausal
   women; Blacks
ID METABOLIC SYNDROME; PHYSICAL-ACTIVITY; NATIONAL-HEALTH; FAMILY-HISTORY;
   PREVALENCE; BEHAVIORS; STRESS; WHITE
AB Background Allostatic load comprises cardiovascular, metabolic, and inflammatory markers, which is characterized by abdominal obesity, high blood glucose levels, impaired glucose tolerance, dyslipidemia, and hypertension and associated with an increased risk in breast cancer.
   Methods The study was a 6-month, 3-arm randomized controlled trial of two moderate-intensity exercise interventions (compared with a control group) among obese, physically inactive, postmenopausal Black women aged 45 to 65 years, who were at increased risk for breast cancer based on the CARE model. Two hundred thirteen participants were randomly assigned to (1) supervised, facility-based aerobic exercise intervention (n = 73), (2) home-based exercise intervention (n= 69), or (3) a wait-listed control group (n =71). The intervention effects of exercise on allostatic load were examined with intent-to-treat analyses using generalized linear models.
   Results It was revealed that statistically significant decreases in allostatic load over the 6-month period for both exercise intervention groups (i.e., home-based and supervised arms) compared to the controls were observed among the total population, p(c-h) = 0.023 and p(c-s) = 0.035, as well as among women with a family history of breast cancer, p(c-h) = 0.006 and p(c-s) = 0.012.
   Conclusions Short-term aerobic activity improved allostatic load scores in metabolically unhealthy postmenopausal Black women at increased risk for cancer.
C1 [Adams-Campbell, Lucile L.; Hicks, Jennifer; Lu, Jiachen; Dash, Chiranjeev] Georgetown Univ, Med Ctr, Off Minor Hlth & Hlth Dispar Res, Georgetown Lombardi Comprehens Canc Ctr, 1000 New Jersey Ave SE, Washington, DC 20003 USA.
   [Taylor, Teletia] Howard Univ, Howard Univ Canc Ctr, Washington, DC 20059 USA.
   [Lu, Jiachen] Univ Texas Hlth Sci Ctr Houston, Houston, TX 77030 USA.
C3 Georgetown University; Howard University; University of Texas System;
   University of Texas Health Science Center Houston
RP Adams-Campbell, LL (corresponding author), Georgetown Univ, Med Ctr, Off Minor Hlth & Hlth Dispar Res, Georgetown Lombardi Comprehens Canc Ctr, 1000 New Jersey Ave SE, Washington, DC 20003 USA.
EM lla9@georgetown.edu
FU NIH NIMHD [1P60MD006920-01]; NIH/NCI [P30 CA051008]; GHUCCTS
   [UL1TR001409]; National Cancer Institute [K07 CA197112-02]; National
   Cancer Institute [P30CA051008] Funding Source: NIH RePORTER
FX This study is supported by grants from NIH NIMHD (1P60MD006920-01). The
   Georgetown Lombardi Comprehensive Cancer Center Biostatistics &
   Bioinformatics Shared Resource is partially supported by NIH/NCI grant
   P30 CA051008 and GHUCCTS grant UL1TR001409. CD is supported by the
   National Cancer Institute training grant K07 CA197112-02 (C. Dash). The
   content is solely the responsibility of the authors and does not
   necessarily represent the official views of the National Cancer
   Institute or the National Institutes of Health.
CR [Anonymous], 2016, CANC FACTS FIGURES A
   [Anonymous], 2017, BREAST CANC FACTS FI
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NR 20
TC 11
Z9 12
U1 0
U2 6
PU SPRINGER INT PUBL AG
PI CHAM
PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND
SN 2197-3792
EI 2196-8837
J9 J RACIAL ETHN HEALTH
JI J. Racial Ethn. Health Disparities
PD OCT
PY 2022
VL 9
IS 5
BP 2063
EP 2069
DI 10.1007/s40615-021-01145-x
EA SEP 2021
PG 7
WC Public, Environmental & Occupational Health
WE Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA 4M5EI
UT WOS:000700987500003
PM 34580826
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Chou, YT
   Li, CH
   Shen, WC
   Yang, YC
   Lu, FH
   Wu, JS
   Chang, CJ
AF Chou, Yu-Tsung
   Li, Chung-Hao
   Shen, Wei-Chen
   Yang, Yi-Ching
   Lu, Feng-Hwa
   Wu, Jin-Shang
   Chang, Chih-Jen
TI Association of sleep quality and sleep duration with serum uric acid
   levels in adults
SO PLOS ONE
LA English
DT Article
ID FATTY LIVER-DISEASE; METABOLIC SYNDROME; CIGARETTE-SMOKING; OXIDATIVE
   STRESS; INCIDENT GOUT; WEIGHT-GAIN; FOLLOW-UP; RISK; HYPERURICEMIA;
   PREVALENCE
AB Objective To date, the association between sleep duration or sleep quality and hyperuricemia has remained unclear. In addition, sleep duration and quality were not considered concomitantly in previous studies. Thus, this study was aimed toward an examination of the association of sleep duration and quality with uric acid level in a Taiwanese population. Methods A total of 4,555 patients aged >= 18 years were enrolled in this study. The sleep duration was classified into three groups: short (<7 h), normal (7-9 h), and long (>= 9 h). The Pittsburgh Sleep Quality Index (PSQI) was used to evaluate sleep quality, and poor sleep quality was defined as a global PSQI score of >5. Results Poor sleepers were younger and had lower body mass index, blood pressure, uric acid, blood sugar, cholesterol, creatinine level, shorter sleep duration, and engaged in less exercise but had a higher white blood cell count and prevalence of smoking as compared to good sleepers. There were also differences in body mass index, blood pressure, uric acid, blood sugar, lipid profiles, and sleep quality among subjects with different sleep durations. After adjusting for other variables, poor sleep quality was associated with lower uric acid levels. In addition, short sleep duration was positively associated with higher uric acid levels. Conclusions Poor sleep quality was related to lower uric acid levels, whereas short sleep duration was associated with higher uric acid levels.
C1 [Chou, Yu-Tsung; Li, Chung-Hao; Shen, Wei-Chen; Yang, Yi-Ching; Lu, Feng-Hwa; Wu, Jin-Shang; Chang, Chih-Jen] Natl Cheng Kung Univ, Natl Cheng Kung Univ Hosp, Coll Med, Dept Family Med, Tainan, Taiwan.
   [Chou, Yu-Tsung; Li, Chung-Hao] Natl Cheng Kung Univ, Natl Cheng Kung Univ Hosp, Coll Med, Dept Hlth Management Ctr, Tainan, Taiwan.
   [Yang, Yi-Ching; Lu, Feng-Hwa; Wu, Jin-Shang] Natl Cheng Kung Univ, Coll Med, Dept Family Med, Tainan, Taiwan.
   [Wu, Jin-Shang] Natl Cheng Kung Univ, Natl Cheng Kung Univ Hosp, Coll Med, Dept Family Med,Dou Liou Branch, Douliu City, Yunlin, Taiwan.
   [Chang, Chih-Jen] Chia Yi Christian Hosp, Dept Family Med, Ditmanson Med Fdn, Chiayi, Taiwan.
C3 National Cheng Kung University; National Cheng Kung University Hospital;
   National Cheng Kung University; National Cheng Kung University Hospital;
   National Cheng Kung University; National Cheng Kung University; National
   Cheng Kung University Hospital
RP Wu, JS; Chang, CJ (corresponding author), Natl Cheng Kung Univ, Natl Cheng Kung Univ Hosp, Coll Med, Dept Family Med, Tainan, Taiwan.; Wu, JS (corresponding author), Natl Cheng Kung Univ, Coll Med, Dept Family Med, Tainan, Taiwan.; Wu, JS (corresponding author), Natl Cheng Kung Univ, Natl Cheng Kung Univ Hosp, Coll Med, Dept Family Med,Dou Liou Branch, Douliu City, Yunlin, Taiwan.; Chang, CJ (corresponding author), Chia Yi Christian Hosp, Dept Family Med, Ditmanson Med Fdn, Chiayi, Taiwan.
EM jins@mail.ncku.edu.tw; changcj.ncku@gmail.com
RI Chou, Yu-tsung/AAV-1165-2021; Chen, Yun-Yu/IXO-3895-2023; LI,
   CHUNG-HAO/W-6529-2019
OI LI, CHUNG-HAO/0000-0001-5062-8128; Chou, Yu-Tsung/0000-0001-9505-2230
FU National Cheng Kung University Hospital, Taiwan [NCKUH10903022]
FX This research was funded by the National Cheng Kung University Hospital,
   Taiwan (NCKUH10903022). The funders had no role in study design, data
   collection and analysis, decision to publish, or preparation of the
   manuscript.
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NR 75
TC 18
Z9 21
U1 3
U2 21
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD SEP 17
PY 2020
VL 15
IS 9
AR e0239185
DI 10.1371/journal.pone.0239185
PG 13
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA NU7VY
UT WOS:000573848800084
PM 32941519
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Dunn, MA
   Rogal, SS
   Duarte-Rojo, A
   Lai, JC
AF Dunn, Michael A.
   Rogal, Shari S.
   Duarte-Rojo, Andres
   Lai, Jennifer C.
TI Physical Function, Physical Activity, and Quality of Life After Liver
   Transplantation
SO LIVER TRANSPLANTATION
LA English
DT Review
ID SOLID-ORGAN TRANSPLANTATION; EXERCISE; SARCOPENIA; MUSCLE; SPORT;
   PERFORMANCE; RECIPIENTS; MORTALITY; CAPACITY; PROGRAM
AB Robust physical activity after liver transplantation is an important determinant of longterm health, similar in its importance to the value of pretransplant activity for withstanding the immediate stress of transplantation. Although transplantation normally enables rapid recovery of liver synthetic and metabolic functions, the recovery of physical capacity and performance to normal levels is delayed and often incomplete. Anatomic measurements of sarcopenia and the physical performance indicators of frailty both tend to improve slowly, and they may, in fact, decrease further in the posttransplant period, especially when the common extrahepatic drivers of muscle loss, such as the elements of the metabolic syndrome, persist or intensify after transplantation. Posttransplant exercise improves fitness, which is a conclusion based on 2 observational studies and 3 randomized trials that assessed endpoints of strength testing, energy expenditure in metabolic equivalents, and peak or maximal oxygen uptake. Importantly, 1 controlled trial found that exercise also improved quality of life (QOL) measured by the Short Form 36 survey, consistent with multiple reports of the value of social support and engagement in sports activity for improving posttransplant QOL. Developing evidence-based standards for post-liver transplant physical activity baseline testing and sustainment of intensity and quality is a key unmet need in transplant hepatology. At present, it is reasonable for transplant teams to assess fitness and design a tailored exercise program when a recipient is first discharged, to record and reinforce progress at all posttransplant visits, and to set realistic longterm performance goals that will often achieve recommended standards for the healthy general population.
C1 [Dunn, Michael A.; Duarte-Rojo, Andres] Univ Pittsburgh, Ctr Liver Dis, Dept Gastroenterol Hepatol & Nutr, Pittsburgh, PA USA.
   [Rogal, Shari S.] Univ Pittsburgh, Dept Med, Pittsburgh, PA USA.
   [Dunn, Michael A.; Duarte-Rojo, Andres] Univ Pittsburgh, Thomas E Starzl Transplantat Inst, Pittsburgh, PA USA.
   [Dunn, Michael A.; Duarte-Rojo, Andres] Univ Pittsburgh, Pittsburgh Liver Res Ctr, Pittsburgh, PA USA.
   [Rogal, Shari S.] VA Pittsburgh Healthcare Syst, Ctr Hlth Equ Res & Promot, Pittsburgh, PA USA.
   [Lai, Jennifer C.] Univ Calif San Francisco, Dept Med, Div Gastroenterol & Hepatol, San Francisco, CA 94143 USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE); University
   of Pittsburgh; Pennsylvania Commonwealth System of Higher Education
   (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of
   Higher Education (PCSHE); University of Pittsburgh; Pennsylvania
   Commonwealth System of Higher Education (PCSHE); University of
   Pittsburgh; US Department of Veterans Affairs; Veterans Health
   Administration (VHA); VA Pittsburgh Healthcare System; University of
   California System; University of California San Francisco
RP Dunn, MA (corresponding author), Univ Pittsburgh, Dept Med, Ctr Liver Dis, Div Gastroenterol Hepatol & Nutr, Kaufmann 201,3459 Fifth Ave, Pittsburgh, PA 15213 USA.
EM dunnma@upmc.edu
RI Rogal, Shari/AGN-8326-2022
OI Duarte-Rojo, Andres/0000-0002-5377-9295; Rogal,
   Shari/0000-0001-8184-1546; Lai, Jennifer/0000-0003-2092-6380
FU NIDA NIH HHS [K23 DA048182] Funding Source: Medline
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NR 42
TC 63
Z9 65
U1 1
U2 20
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1527-6465
EI 1527-6473
J9 LIVER TRANSPLANT
JI Liver Transplant.
PD MAY
PY 2020
VL 26
IS 5
BP 702
EP 708
DI 10.1002/lt.25742
PG 7
WC Gastroenterology & Hepatology; Surgery; Transplantation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery; Transplantation
GA LE8YU
UT WOS:000527015500011
PM 32128971
OA Green Submitted, Green Accepted
DA 2025-06-11
ER

PT J
AU Abou-Samra, M
   Selvais, CM
   Dubuisson, N
   Brichard, SM
AF Abou-Samra, Michel
   Selvais, Camille M.
   Dubuisson, Nicolas
   Brichard, Sonia M.
TI Adiponectin and Its Mimics on Skeletal Muscle: Insulin Sensitizers, Fat
   Burners, Exercise Mimickers, Muscling Pills ... or Everything Together?
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE Adiponectin; skeletal muscle; AMPK; PGC-1 alpha; insulin signaling;
   obesity; inflammation; oxidative stress; regeneration; exercise;
   dystrophinopathies; AdipoRon
ID ACTIVATED PROTEIN-KINASE; ISCHEMIA-REPERFUSION INJURY; DUCHENNE
   MUSCULAR-DYSTROPHY; MOLECULE ADIPOR AGONIST; NF-KAPPA-B; GLOBULAR
   ADIPONECTIN; ACID OXIDATION; T-CADHERIN; PHYSICAL-EXERCISE; RECEPTOR
   AGONIST
AB Adiponectin (ApN) is a hormone abundantly secreted by adipocytes and it is known to be tightly linked to the metabolic syndrome. It promotes insulin-sensitizing, fat-burning, and anti-atherosclerotic actions, thereby effectively counteracting several metabolic disorders, including type 2 diabetes, obesity, and cardiovascular diseases. ApN is also known today to possess powerful anti-inflammatory/oxidative and pro-myogenic effects on skeletal muscles exposed to acute or chronic inflammation and injury, mainly through AdipoR1 (ApN specific muscle receptor) and AMP-activated protein kinase (AMPK) pathway, but also via T-cadherin. In this review, we will report all the beneficial and protective properties that ApN can exert, specifically on the skeletal muscle as a target tissue. We will highlight its effects and mechanisms of action, first in healthy skeletal muscle including exercised muscle, and second in diseased muscle from a variety of pathological conditions. In the end, we will go over some of AdipoRs agonists that can be easily produced and administered, and which can greatly mimic ApN. These interesting and newly identified molecules could pave the way towards future therapeutic approaches to potentially prevent or combat not only skeletal muscle disorders but also a plethora of other diseases with sterile inflammation or metabolic dysfunction.
C1 [Abou-Samra, Michel; Selvais, Camille M.; Dubuisson, Nicolas; Brichard, Sonia M.] Catholic Univ Louvain, Med Sect, Inst Expt & Clin Res, Endocrinol Diabet & Nutr Unit, B-1200 Brussels, Belgium.
C3 Universite Catholique Louvain
RP Brichard, SM (corresponding author), Catholic Univ Louvain, Med Sect, Inst Expt & Clin Res, Endocrinol Diabet & Nutr Unit, B-1200 Brussels, Belgium.
EM michel.abousamra@uclouvain.be; camille.selvais@uclouvain.be;
   nicolas.j.dubuisson@uclouvain.be; sonia.brichard@uclouvain.be
RI Brichard, Sonia/B-4597-2013
OI Dubuisson, Nicolas/0000-0003-4258-0579; ABOU-SAMRA,
   Michel/0000-0003-2312-7998
FU Belgian Telethon (ABMM); French Association against Myopathies (AFM
   Telethon) [H121203009]; Fund for Scientific Research-FNRS [T.0212.13];
   fund Cremers-Opdebeeck
FX This work was funded by grants from the Belgian Telethon (ABMM), the
   French Association against Myopathies (AFM Telethon; H121203009), the
   Fund for Scientific Research-FNRS (T.0212.13), and the fund
   Cremers-Opdebeeck managed by the King Baudouin Foundation. BioRender.com
   was used for the creation of figures.
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NR 145
TC 56
Z9 60
U1 2
U2 13
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD APR
PY 2020
VL 21
IS 7
AR 2620
DI 10.3390/ijms21072620
PG 21
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA LR3DN
UT WOS:000535574200362
PM 32283840
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Heidari, A
   Hamidi, G
   Soleimani, A
   Aghadavod, E
   Asemi, Z
AF Heidari, Akbar
   Hamidi, Gholamali
   Soleimani, Alireza
   Aghadavod, Esmat
   Asemi, Zatollah
TI Effects of Coenzyme Q10 Supplementation on Gene Expressions Related to
   Insulin, Lipid, and Inflammation Pathways in Patients With Diabetic
   Nephropathy
SO IRANIAN JOURNAL OF KIDNEY DISEASES
LA English
DT Article
DE coenzyme Q10; gene expression; insulin; lipid; inflammation; diabetic
   nephropathy
ID PROLIFERATOR-ACTIVATED RECEPTORS; NECROSIS-FACTOR-ALPHA; METABOLIC
   SYNDROME; OXIDATIVE STRESS; DOUBLE-BLIND; CYTOKINE; RATS; INDUCTION;
   INCREASES; PROFILES
AB Introduction. Data on the effects of coenzyme Q10 (CQ10) on gene expression related to insulin, lipid, and inflammation in patients with diabetic nephropathy (DN) are scarce. This study aimed to determine the effects of CQ10 supplementation on gene expression related to insulin, lipid, and inflammation pathways in patients with DN.
   Materials and Methods. Forty patients with DN, aged 40 to 85 years old, were randomly assigned into 2 groups to receive either 100 mg/d of CQ10 supplements (n = 20) or placebo (n = 20), for 12 weeks. Gene expression related to signaling pathway of insulin, lipid, and inflammation were determined in blood samples using a reverse transcriptase polymerase chain reaction method.
   Results. Quantitative results of reverse transcriptase polymerase chain reaction demonstrated that compared with the placebo, CQ10 administration upregulated gene expression of peroxisome proliferator-activated receptor-gamma (P = .02) in peripheral blood mononuclear cells of the patients with DN. In addition, compared with the placebo, CQ10 supplementation downregulated gene expression of interleukin-1 (P = .003) and tumor necrosis factor-alpha (P = .02). No significant effects were observed on gene expression of oxidized low-density lipoprotein, lipoprotein(a), glucose transporter-1, transforming growth factor-beta in the CQ10 group.
   Conclusions. Overall, CQ10 supplementation for 12 weeks in DN patients significantly improved gene expression of peroxisome proliferator-activated receptor-gamma, interleukin-1, and tumor necrosis factor-alpha.
C1 [Heidari, Akbar; Aghadavod, Esmat; Asemi, Zatollah] Kashan Univ Med Sci, Res Ctr Biochem & Nutr Metab Dis, Kashan, Iran.
   [Hamidi, Gholamali] Kashan Univ Med Sci, Physiol Res Ctr, Kashan, Iran.
   [Soleimani, Alireza] Kashan Univ Med Sci, Dept Internal Med, Kashan, Iran.
RP Asemi, Z (corresponding author), Kashan Univ Med Sci, Res Ctr Biochem & Nutr Metab Dis, Kashan, Iran.
EM asemi_r@yahoo.com
RI Soleimani, Alireza/I-1657-2018; asemi, zatollah/J-2677-2018; heidari,
   Akbar/AAG-7775-2021; Hamidi, Gholam/F-5992-2017; Aghadavod,
   Esmat/I-7736-2017
OI Aghadavod, Esmat/0000-0001-9456-9238
FU Kashan University of Medical Sciences
FX This study was funded by a grant from the Vice-Chancellor for Research,
   Kashan University of Medical Sciences.
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NR 38
TC 27
Z9 28
U1 0
U2 4
PU IRANIAN SOC NEPHROLGY
PI TEHRAN
PA APT 12, NO 63, SHAHEED TOUSI ST, DR GHARIB ST, KESHAVARZ BLVD, TEHRAN,
   1419783311, IRAN
SN 1735-8582
EI 1735-8604
J9 IRAN J KIDNEY DIS
JI Iran. J. Kidney Dis.
PD JAN
PY 2018
VL 12
IS 1
BP 14
EP 21
PG 8
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA FX2VO
UT WOS:000425922000004
PM 29421772
DA 2025-06-11
ER

PT J
AU Santos, SHS
   Fernandes, LR
   Pereira, CS
   Guimaraes, ALS
   de Paula, AMB
   Campagnole-Santos, MJ
   Alvarez-Leite, JI
   Bader, M
   Santos, RAS
AF Santos, Sergio Henrique S.
   Fernandes, Luciana Rodrigues
   Pereira, Camila Santos
   Senna Guimaraes, Andre L.
   de Paula, Alfredo M. B.
   Campagnole-Santos, Maria Jose
   Alvarez-Leite, Jacqueline Isaura
   Bader, Michael
   Santos, Robson Augusto S.
TI Increased circulating angiotensin-(1-7) protects white adipose tissue
   against development of a proinflammatory state stimulated by a high-fat
   diet
SO REGULATORY PEPTIDES
LA English
DT Article
DE Angiotensin-(1-7); Metabolism; Hyperlipidic diet; Obesity; Inflammation
ID TUMOR-NECROSIS-FACTOR; INSULIN-RESISTANCE; INDUCED OBESITY; RECEPTOR
   ANTAGONIST; METABOLIC SYNDROME; INFLAMMATION; INTERLEUKIN-1; ADIPOKINES;
   MICE; MASS
AB Introduction: The aim of the present study was to evaluate the effect of a transgenic-induced chronic increase of Ang-(1-7) on the expression of inflammatory markers in adipose tissue and the metabolic profile in rats treated with high-fat diet.
   Research design and methods: Transgenic rats expressing an Ang-(1-7)-producing fusion protein (TGR L-3292) and Sprague Dawley (SD) control rats 4 weeks old were treated for 8 weeks with a high-fat diet. Food intake and body weight were measured once a week. Glucose-tolerance and insulin sensitivity tests were performed one week before the sacrifice. At the end of the experiment plasma lipid concentrations were measured in TGR and SD rats. Adipose tissue were weighted and corrected by the body weight. Proinflammatory markers in adipose tissue were analyzed using Western-blotting, real time-PCR and immunohistochemistry.
   Results: High-fat diet TGR rats presented increased HDL cholesterol levels and decreased abdominal fat mass, without changes in food intake. In addition, rats with increased Ang-(1-7) levels had lower body weight. Molecular analysis revealed decreased IL-1 beta and COX-2 in adipose tissue.
   Conclusions: Taken together, these results show that chronic high circulating angiotensin-(1-7) levels protect against metabolic stress induced by a high-fat diet decreasing the proinflammatory profile of adipose tissue. (C) 2012 Elsevier B.V. All rights reserved.
C1 [Santos, Sergio Henrique S.; Campagnole-Santos, Maria Jose; Santos, Robson Augusto S.] Univ Fed Minas Gerais, Dept Physiol, Biol Sci Inst ICB, Natl Inst Sci & Technol INCT NanoBiofar, BR-31270901 Belo Horizonte, MG, Brazil.
   [Fernandes, Luciana Rodrigues; Alvarez-Leite, Jacqueline Isaura] Univ Fed Minas Gerais, Inst Biol Sci, Dept Biochem, Lab Nutr Biochem, BR-31270901 Belo Horizonte, MG, Brazil.
   [Santos, Sergio Henrique S.; Pereira, Camila Santos; Senna Guimaraes, Andre L.; de Paula, Alfredo M. B.] Univ Estadual Montes Claros, Lab Hlth Sci, Postgrad Program Hlth Sci, Montes Claros, MG, Brazil.
   [Bader, Michael] Max Delbruck Ctr Mol Med MDC, Berlin, Germany.
C3 Universidade Federal de Minas Gerais; Universidade Federal de Minas
   Gerais; Universidade Estadual de Montes Claros; Helmholtz Association;
   Max Delbruck Center for Molecular Medicine
RP Santos, RAS (corresponding author), Univ Fed Minas Gerais, Lab Hipertensao, Dept Fisiol & Biofis, Av Antonio Carlos 6627-ICB, BR-31270901 Belo Horizonte, MG, Brazil.
EM sergiosousas@hotmail.com; robsonsant@gmail.com
RI Fernandes, Luciana/KHV-9227-2024; Santos, Robson/C-9336-2011; Bader,
   Michael/K-2124-2013; Santos, Sérgio/D-8143-2011; Campagnole-Santos,
   Maria/AAK-7515-2020; De Paula, Alfredo/K-3015-2012; Campagnole-Santos,
   Maria/F-5590-2017; ALVAREZ-LEITE, JACQUELINE/C-9175-2014; Guimaraes,
   Andre/D-8122-2011
OI Santos, Robson/0000-0001-8738-5852; Campagnole-Santos,
   Maria/0000-0001-9483-4206; ALVAREZ-LEITE,
   JACQUELINE/0000-0001-6601-9853; Bader, Michael/0000-0003-4780-4164;
   Santos, Sergio/0000-0002-7788-5447; De Paula,
   Alfredo/0000-0002-8715-0030; Guimaraes, Andre/0000-0002-3162-3206
FU CNPq (INCT-NanoBiofar); Fapemig; CAPES
FX Acknowledgments: This work was supported by a grant from CNPq
   (INCT-NanoBiofar), Fapemig and CAPES.
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NR 48
TC 75
Z9 83
U1 0
U2 6
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0167-0115
EI 1873-1686
J9 REGUL PEPTIDES
JI Regul. Pept.
PD OCT 10
PY 2012
VL 178
IS 1-3
BP 64
EP 70
DI 10.1016/j.regpep.2012.06.009
PG 7
WC Endocrinology & Metabolism; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Physiology
GA 014ML
UT WOS:000309379800011
PM 22749992
OA hybrid
DA 2025-06-11
ER

PT J
AU Lin, CY
   Chen, PC
   Kuo, HK
   Lin, LY
   Lin, JW
   Hwang, JJ
AF Lin, C-Y.
   Chen, P-C.
   Kuo, H-K.
   Lin, L-Y.
   Lin, J-W.
   Hwang, J-J
TI Effects of obesity, physical activity, and cardiorespiratory fitness on
   blood pressure, inflammation, and insulin resistance in the National
   Health and Nutrition Survey 1999-2002
SO NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
LA English
DT Article
DE Exercise; Inflammation; Insulin Resistance; Model, Structural
ID C-REACTIVE PROTEIN; LIFE-STYLE INTERVENTION; METABOLIC SYNDROME;
   CARDIOVASCULAR-DISEASE; AEROBIC EXERCISE; PREVENTION; SEDENTARY; HUMANS;
   ADULTS; WOMEN
AB Background and aims: This study was designed to elucidate the effects of obesity, self-reported physical activity and cardiorespiratory fitness on blood pressure, inflammation, and insulin resistance.
   Methods and results: Data from 950 Caucasian subjects ranging in age from 19 to 49 years from the National Health and Nutrition Survey (NHANES), 1999-2002, were included to construct a population-based observational study. Cardiorespiratory fitness (VO2 max) was predicted from a submaximal exercise stress test. Self-reported physical activity was measured by metabolic equivalent score transformed from a questionnaire. A structural equation model (SEM) was developed to examine the relationship between obesity, cardiorespiratory fitness, self-reported physical activity, and hypertension, inflammation, and insulin resistance. The model showed that obesity was positively linked to hypertension (B = 0.50, P < 0001) and C-reactive protein (CRP; B = 0.15, p < 0.05), which in turn led to insulin resistance (B = 0.44, P < 0.05). Increased cardiorespiratory fitness was negatively associated with CRP (F = 0.23, P < 0.01), but not correlated to hypertension after adjustment for potential confounding factors. No significant association was found between self-reported physical activity and hypertension, insulin resistance, and CRP.
   Conclusion: Obesity contributes to the development of hypertension, inflammation, and insulin resistance. Improved cardiorespiratory fitness might lead to clinical and biochemical improvement in insulin resistance by reducing the inflammatory state. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Kuo, H-K.; Lin, L-Y.] Natl Taiwan Univ Hosp, Dept Internal Med, Taipei 100, Taiwan.
   [Lin, C-Y.] En Chu Kong Hosp, Nephrol Sect, Dept Internal Med, Taipei Cty, Taiwan.
   [Lin, C-Y.; Chen, P-C.] Natl Taiwan Univ, Coll Publ Hlth, Inst Occupat Med & Ind Hyg, Taipei 10764, Taiwan.
   [Lin, C-Y.] Fu Jen Catholic Univ, Sch Med, Taipei Cty, Taiwan.
   [Lin, J-W.; Hwang, J-J] Natl Taiwan Univ Hosp, Yun Lin Branch, Ctr Cardiovasc, Dou Liou City, Yun Lin County, Taiwan.
   [Lin, J-W.; Hwang, J-J] Natl Taiwan Univ, Coll Med, Dept Med, Taipei 10764, Taiwan.
C3 National Taiwan University; National Taiwan University Hospital;
   National Taiwan University; Fu Jen Catholic University; National Taiwan
   University; National Taiwan University Hospital; National Taiwan
   University
RP Lin, LY (corresponding author), Natl Taiwan Univ Hosp, Dept Internal Med, Taipei 100, Taiwan.
EM lin7010@yahoo.com.tw; jouweilin@yahoo.com
RI Lin, Yen-Hung/AAQ-1242-2020; Zhang, Zhenyu/GZL-8479-2022; Chen,
   Pau-Chung/H-5686-2011
OI LIN, LIAN-YU/0000-0001-7505-6429; Chen, Pau-Chung/0000-0002-6242-5974;
   Hwang, Juey-Jen/0000-0001-6437-0455
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NR 35
TC 39
Z9 47
U1 0
U2 18
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0939-4753
EI 1590-3729
J9 NUTR METAB CARDIOVAS
JI Nutr. Metab. Carbiovasc. Dis.
PD DEC
PY 2010
VL 20
IS 10
BP 713
EP 719
DI 10.1016/j.numecd.2009.06.005
PG 7
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism; Nutrition
   & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism;
   Nutrition & Dietetics
GA 710BZ
UT WOS:000286487200004
PM 19748250
DA 2025-06-11
ER

PT J
AU Brady, R
   Brown, WJ
   Hillsdon, M
   Mielke, G
AF Brady, Ruth
   Brown, Wendy J.
   Hillsdon, Melvyn
   Mielke, Gregore, I
TI Patterns of Accelerometer-Measured Physical Activity and Health Outcomes
   in Adults: A Systematic Review
SO MEDICINE & SCIENCE IN SPORTS & EXERCISE
LA English
DT Review
DE BOUT DURATION; INTENSITY; DAILY; WEEKLY FREQUENCY; EXERCISE;
   EPIDEMIOLOGY
ID DWELLING OLDER-ADULTS; SEDENTARY BEHAVIOR; METABOLIC SYNDROME;
   ASSOCIATION; TIME; MODERATE; BOUTS; INTENSITY; MARKERS; FRAILTY
AB Purpose The aim of this study was to systematically review the literature on accelerometer-measured physical activity and health outcomes in adults. Methods Eight electronic databases were searched for relevant articles published up to March 2021. Only population-based studies of adults (age >= 18 yr) that directly compared two or more categories of physical activity (i.e., bout duration, intensity, and daily/weekly frequency) with a health outcome (e.g., mortality, cardiometabolic, healthy aging, depression, sleep, and brain structure) were included. Results Of the 15,923 publications retrieved, 52 articles were included. Twenty-eight studies directly compared the associations between physical activity accumulated in different bout durations, 31 studies directly compared the associations between physical activity accumulated in different intensities, and 9 studies directly compared the associations between the effects of varying daily and weekly frequencies of physical activity, with health outcomes. Most showed no differences in relationships with health outcomes when physical activity was accumulated in short (<10-min) or long (>= 10-min) bouts. Overall, there were no differences in the relationships with most health outcomes when different intensities and daily/weekly frequencies were compared. However, in most studies, researchers did not adjust their analyses for total volume of physical activity. Moreover, variations in researcher-driven decisions about data collection and processing methods made it difficult to compare study findings. Conclusions These findings suggest that physical activity accumulated in many patterns of bout duration, intensity, or daily/weekly frequency is associated with a range of beneficial health outcomes in adults. Lack of adjustment for total volume of physical activity in most studies and inconsistent methods for defining components of physical activity prevent firm conclusions about which specific patterns of bout duration, intensity, and daily/weekly frequency are most important for health benefits.
C1 [Brady, Ruth; Brown, Wendy J.; Mielke, Gregore, I] Univ Queensland, Sch Human Movement & Nutr Sci, Brisbane, Qld, Australia.
   [Brady, Ruth; Hillsdon, Melvyn] Univ Exeter, Sport & Hlth Sci, Exeter, Devon, England.
   [Mielke, Gregore, I] Univ Queensland, Sch Publ Hlth, Brisbane, Qld, Australia.
C3 University of Queensland; University of Exeter; University of Queensland
RP Brady, R (corresponding author), Univ Queensland, Sch Human Movement & Nutr Sci 26B, St Lucia Campus,Rm 319, Brisbane, Qld 4072, Australia.
EM ruth.brady@uq.net.au
RI Brown, Wendy/A-1553-2016; Mielke, Gregore/E-2141-2014; Brown, Wendy
   J/G-2201-2010
OI Brown, Wendy J/0000-0001-9093-4509
FU University of Queensland; University of Exeter Institute Studentship;
   National Health and Medical Research Council [APP2008702]
FX R. B. is supported by a University of Queensland and University of
   Exeter Institute Studentship. G. I. M. is supported by a National Health
   and Medical Research Council Investigator Grant (APP2008702). R. B., W.
   J. B., M. H., andG. I. M. declare that they have no conflict of
   interest. The results of the present study do not constitute
   endorsements by the American College of Sports Medicine. The conclusions
   of the present study are presented clearly, honestly, and without
   fabrication, falsification, or inappropriate data manipulation.
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NR 74
TC 19
Z9 21
U1 8
U2 23
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0195-9131
EI 1530-0315
J9 MED SCI SPORT EXER
JI Med. Sci. Sports Exerc.
PD JUL
PY 2022
VL 54
IS 7
BP 1155
EP 1166
DI 10.1249/MSS.0000000000002900
PG 12
WC Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Sport Sciences
GA 2C7PH
UT WOS:000811055000014
PM 35220369
DA 2025-06-11
ER

PT J
AU Ng, TP
   Lee, TS
   Lim, WS
   Chong, MS
   Yap, P
   Cheong, CY
   Yap, KB
   Rawtaer, I
   Liew, TM
   Gao, Q
   Gwee, X
   Ng, MPE
   Nicholas, SO
   Wee, SL
AF Ng, Tze Pin
   Lee, T. S.
   Lim, W. S.
   Chong, M. S.
   Yap, P.
   Cheong, C. Y.
   Yap, K. B.
   Rawtaer, I.
   Liew, T. M.
   Gao, Q.
   Gwee, X.
   Ng, M. P. E.
   Nicholas, S. O.
   Wee, S. L.
TI Development, Validation and Field Evaluation of the Singapore
   Longitudinal Ageing Study (SLAS) Risk Index for Prediction of Mild
   Cognitive Impairment and Dementia
SO JPAD-JOURNAL OF PREVENTION OF ALZHEIMERS DISEASE
LA English
DT Article
DE Mild cognitive impairment; dementia; metabolic syndrome; diabetes;
   cardiovascular risk factors
AB Background Mild cognitive impairment (MCI) is a critical pre-dementia target for preventive interventions. There are few brief screening tools based on self-reported personal lifestyle and health-related information for predicting MCI that have been validated for their generalizability and utility in primary care and community settings. Objective To develop and validate a MCI risk prediction index, and evaluate its field application in a pilot community intervention trial project. Design Two independent population-based cohorts in the Singapore Longitudinal Ageing Study (SLAS). We used SLAS1 as a development cohort to construct the risk assessment instrument, and SLA2 as a validation cohort to verify its generalizability. Setting Community-based screening and lifestyle intervention Participants: (1) SLAS1 cognitively normal (CN) aged >= 55 years with average 3 years (N=1601); (2) SLAS2 cohort (N=3051) with average 4 years of follow up. (3) 437 participants in a pilot community intervention project. Measurements The risk index indicators included age, female sex, years of schooling, hearing loss, depression, life satisfaction, number of cardio-metabolic risk factors (wide waist circumference, pre-diabetes or diabetes, hypertension, dyslipidemia). Weighted summed scores predicted probabilities of MCI or dementia. A self-administered questionnaire field version of the risk index was deployed in the pilot community project and evaluated using pre-intervention baseline cognitive function of participants. Results Risk scores were associated with increasing probabilities of progression to MCI-or-dementia in the development cohort (AUC=0.73) and with increased prevalence and incidence of MCI-or-dementia in the validation cohort (AUC=0.74). The field questionnaire risk index identified high risk individuals with strong correlation with RBANS cognitive scores in the community program (p<0.001). Conclusions The SLAS risk index is accurate and replicable in predicting MCI, and is applicable in community interventions for dementia prevention.
C1 [Ng, Tze Pin; Gao, Q.; Gwee, X.] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Psychol Med, Gerontol Res Programme, Singapore, Singapore.
   [Ng, Tze Pin; Chong, M. S.; Ng, M. P. E.; Nicholas, S. O.; Wee, S. L.] Geriatr Educ & Res Inst, Singapore, Singapore.
   [Lee, T. S.] Duke NUS Med Sch, Singapore, Singapore.
   [Lim, W. S.] Tan Tock Seng Hosp, Dept Geriatr Med, Singapore, Singapore.
   [Yap, P.; Cheong, C. Y.] Khoo Teck Puat Hosp, Dept Geriatr Med, Singapore, Singapore.
   [Yap, K. B.] Ng Teng Fong Gen Hosp, Dept Geriatr Med, Singapore, Singapore.
   [Rawtaer, I.] Sengkang Gen Hosp, Dept Psychiat, Singapore, Singapore.
   [Liew, T. M.] Singapore Gen Hosp, Dept Psychiat, Singapore, Singapore.
   [Wee, S. L.] Singapore Inst Technol, Hlth & Social Sci Cluster, Singapore, Singapore.
C3 National University of Singapore; National University of Singapore; Tan
   Tock Seng Hospital; Singapore General Hospital; Singapore Institute of
   Technology
RP Ng, TP (corresponding author), Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Psychol Med, Level 9,NUHS Tower Block,1E Kent Ridge Rd, Singapore 119228, Singapore.
EM pcmngtp@nus.edu.sg
RI Wee, Shiou-Liang/H-7115-2019; Chong, Mei/A-4978-2013
OI Gwee, Xinyi/0000-0003-3570-1352; Lim, Wee Shiong/0000-0003-3975-7230;
   Wee, Shiou-Liang/0000-0002-7853-4112; Rawtaer, Iris/0000-0002-8214-6454;
   Cheong, Chin Yee/0000-0002-7591-1699
FU Agency for Science Technology and Research (A*STAR) Biomedical Research
   Council (BMRC) [08/1/21/19/567]; National Medical Research Council
   [NMRC/1108/2007]
FX The study was supported by the Agency for Science Technology and
   Research (A*STAR) Biomedical Research Council (BMRC) [grant number
   08/1/21/19/567] and the National Medical Research Council [grant number:
   NMRC/1108/2007].
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NR 23
TC 3
Z9 3
U1 1
U2 13
PU EDITIONS SERDI
PI PARIS
PA 320 RUE SAINT-HONORE, PARIS, 75001, FRANCE
SN 2274-5807
EI 2426-0266
J9 JPAD-J PREV ALZHEIM
JI JPAD-J. Prev. Alzheimers Dis.
PD MAR
PY 2021
VL 8
IS 3
BP 335
EP 344
DI 10.14283/jpad.2021.19
EA APR 2021
PG 10
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA SV9MP
UT WOS:000644276500001
PM 34101792
OA hybrid
DA 2025-06-11
ER

PT J
AU Gimeno-Miguel, A
   Gutiérrez, AG
   Poblador-Plou, B
   Coscollar-Santaliestra, C
   Pérez-Calvo, JI
   Divo, MJ
   Calderón-Larrañaga, A
   Prados-Torres, A
   Ruiz-Laiglesia, FJ
AF Gimeno-Miguel, Antonio
   Gracia Gutierrez, Anyuli
   Poblador-Plou, Beatriz
   Coscollar-Santaliestra, Carlos
   Ignacio Perez-Calvo, J.
   Divo, Miguel J.
   Calderon-Larranaga, Amaia
   Prados-Torres, Alexandra
   Ruiz-Laiglesia, Fernando J.
TI Multimorbidity patterns in patients with heart failure: an observational
   Spanish study based on electronic health records
SO BMJ OPEN
LA English
DT Article
ID METABOLIC SYNDROME; EJECTION FRACTION; CO-MORBIDITIES; PREVALENCE;
   COHORT; ASSOCIATIONS; DEPRESSION; DISEASES; IMPACT; PILOT
AB Objectives To characterise the comorbidities of heart failure (HF) in men and women, to explore their clustering into multimorbidity patterns, and to measure the impact of such patterns on the risk of hospitalisation and mortality.
   Design Observational retrospective population study based on electronic health records.
   Setting EpiChron Cohort (Aragon, Spain).
   Participants All the primary and hospital care patients of the EpiChron Cohort with a diagnosis of HF on 1 January 2011 (ie, 8488 women and 6182 men). We analysed all the chronic diseases registered in patients electronic health records until 31 December 2011.
   Primary outcome We performed an exploratory factor analysis to identify the multimorbidity patterns in men and women, and logistic and Cox proportional-hazards regressions to investigate the association between the patterns and the risk of hospitalisation in 2012, and of 3-year mortality.
   Results Almost all HF patients (98%) had multimorbidity, with an average of 7.8 chronic diseases per patient. We identified six different multimorbidity patterns, named cardiovascular, neurovascular, coronary, metabolic, degenerative and respiratory. The most prevalent were the degenerative (64.0%) and cardiovascular (29.9%) patterns in women, and the metabolic (49.3%) and cardiovascular (43.2%) patterns in men. Every pattern was associated with higher hospitalisation risks; and the cardiovascular, neurovascular and respiratory patterns significantly increased the likelihood of 3-year mortality.
   Conclusions Multimorbidity is the norm rather than the exception in patients with heart failure, whose comorbidities tend to cluster together beyond simple chance in the form of multimorbidity patterns that have different impact on health outcomes. This knowledge could be useful to better understand common pathophysiological pathways underlying this condition and its comorbidities, and the factors influencing the prognosis of men and women with HF. Further large scale longitudinal studies are encouraged to confirm the existence of these patterns as well as their differential impact on health outcomes.
C1 [Gimeno-Miguel, Antonio; Poblador-Plou, Beatriz; Coscollar-Santaliestra, Carlos; Prados-Torres, Alexandra] Aragon Hlth Sci Inst, IIS Aragon, EpiChron Res Grp, Zaragoza, Spain.
   [Gimeno-Miguel, Antonio; Poblador-Plou, Beatriz; Prados-Torres, Alexandra] REDISSEC, Zaragoza, Spain.
   [Gracia Gutierrez, Anyuli; Ignacio Perez-Calvo, J.; Ruiz-Laiglesia, Fernando J.] Lozano Blesa Univ Hosp, Internal Med Serv, IIS Aragon, Res Grp Heart Failure, Zaragoza, Spain.
   [Coscollar-Santaliestra, Carlos] Primary Care Hlth Ctr San Pablo, SALUD, Zaragoza, Spain.
   [Ignacio Perez-Calvo, J.] Univ Zaragoza, Fac Med, Zaragoza, Spain.
   [Divo, Miguel J.] Harvard Med Sch, Brigham & Womens Hosp, Pulm & Crit Care Div, Boston, MA 02115 USA.
   [Calderon-Larranaga, Amaia] Stockholm Univ, Karolinska Inst, Dept Neurobiol Care Sci & Soc, Aging Res Ctr, Stockholm, Sweden.
C3 Lozano Blesa University Clinical Hospital; University of Zaragoza;
   Harvard University; Harvard Medical School; Harvard University Medical
   Affiliates; Brigham & Women's Hospital; Karolinska Institutet; Stockholm
   University
RP Gimeno-Miguel, A (corresponding author), Aragon Hlth Sci Inst, IIS Aragon, EpiChron Res Grp, Zaragoza, Spain.; Gimeno-Miguel, A (corresponding author), REDISSEC, Zaragoza, Spain.
EM agimenomi.iacs@aragon.es
RI Calvo, Juan/I-4194-2019; Gimeno-Miguel, Antonio/AAC-9611-2019;
   Poblador-Plou, Beatriz/ABC-7915-2020; Calderón-Larrañaga,
   Amaia/ABC-6828-2021; Prados-Torres, Alexandra/P-5818-2017
OI Calderon-Larranaga, Amaia/0000-0001-9064-9222; Prados-Torres,
   Alexandra/0000-0002-5704-6056
FU Gobierno de Aragon [B01_17R]; European Regional Development Fund
   'Construyendo Europa desde Aragon'
FX This work was supported by Gobierno de Aragon [B01_17R] and the European
   Regional Development Fund 'Construyendo Europa desde Aragon'. The
   funders played no role in the design of the study, collection, analysis,
   and interpretation of data, or preparation of the manuscript.
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NR 32
TC 40
Z9 42
U1 0
U2 2
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2044-6055
J9 BMJ OPEN
JI BMJ Open
PD DEC
PY 2019
VL 9
IS 12
AR e033174
DI 10.1136/bmjopen-2019-033174
PG 9
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA KK5HS
UT WOS:000512773400230
PM 31874886
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Kavoor, AR
   Mitra, S
   Kumar, S
   Sisodia, AK
   Jain, R
AF Kavoor, Anjana Rao
   Mitra, Sayantanava
   Kumar, Sudhir
   Sisodia, Anil Kr.
   Jain, Rakesh
TI Lipids, aggression, suicidality and impulsivity in drug-naive/drug-free
   patients of schizophrenia
SO ASIAN JOURNAL OF PSYCHIATRY
LA English
DT Article
DE Lipid; Cholesterol; Impulsivity; Schizophrenia
ID LOW SERUM-CHOLESTEROL; LOW HDL CHOLESTEROL; RISK-FACTORS; TRYPTOPHAN
   DEPLETION; BODY-MASS; AFFECTIVE-DISORDER; METABOLIC SYNDROME; MAJOR
   DEPRESSION; LIFETIME RISK; CSF 5-HIAA
AB Aim: Present study aimed at determining lipid profiles in acutely symptomatic drug-naive/drug-free patients of schizophrenia, comparing them with healthy controls and exploring relationships between various lipid fractions, aggression, suicidality and impulsivity in this population.
   Materials and methods: This was a cross-sectional hospital-based study, comparing patients with schizophrenia (M = 46, F = 14; mean age 32.40 +/- 6.6 years; 48 drug-free for 10.50 +/- 9.2 weeks) with 60 age-sex matched healthy controls. Upon recruitment, fasting venous blood samples of all subjects were analysed for total cholesterol, HDL, LDL, VLDL and TG levels, and patients were rated on PANSS for symptom severity, Modified Overt Aggression Scale for aggression, Impulsivity Rating Scale for impulsivity and Scale for Suicide Ideation for suicidality.
   Results: The socio-demographic characteristics of the patients were comparable to controls. In patients, total cholesterol, HDL and LDL levels were found to be significantly lower (p < 0.01) than the control group. When explored further in patients, lower total cholesterol and LDL levels showed significant negative correlations with scores on impulsivity (p < 0.01) and suicidality (p < 0.05); and TG level showed a negative correlation with impulsivity (p < 0.05).
   Conclusions: This study adds to a growing literature on a complex relationship between lipid fractions and impulsivity, suicidality and aggression in schizophrenia; providing interesting insights into the biochemical basis of human behaviour and confirming these in a developing-world population. The implications are many, including a need to review judiciously the promotion of weight loss and cholesterol reduction programmes in constitutionally vulnerable population, at least during their acutely-symptomatic states. (C) 2017 Elsevier B.V. All rights reserved.
C1 [Kavoor, Anjana Rao] Fortis Hosp, Bengaluru, India.
   [Mitra, Sayantanava] NIMHANS, Dept Psychiat, Bengaluru, India.
   [Kumar, Sudhir; Sisodia, Anil Kr.; Jain, Rakesh] Inst Mental Hlth & Hosp, Agra, Uttar Pradesh, India.
C3 National Institute of Mental Health & Neurosciences - India
RP Mitra, S (corresponding author), NIMHANS, Dept Psychiat, Bengaluru, India.
EM sayantanava@gmail.com
RI Kavoor, Anjana/AAQ-9675-2020; Mitra, Sayantanava/AAQ-8233-2020
OI Kavoor, Anjana Rao/0000-0002-4451-2230; Mitra,
   Sayantanava/0000-0001-7923-8887
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NR 98
TC 30
Z9 32
U1 0
U2 10
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1876-2018
EI 1876-2026
J9 ASIAN J PSYCHIATR
JI Asian J. Psychiatr.
PD JUN
PY 2017
VL 27
BP 129
EP 136
DI 10.1016/j.ajp.2017.03.002
PG 8
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychiatry
GA FB3GS
UT WOS:000406031500024
PM 28558886
DA 2025-06-11
ER

PT J
AU Vijayan, VK
AF Vijayan, V. K.
TI Chronic obstructive pulmonary disease
SO INDIAN JOURNAL OF MEDICAL RESEARCH
LA English
DT Review
DE Airflow limitation; air pollution; bronchodilators; chronic obstructive
   pulmonary disease; exacerbations; lung; pulmonary rehabilitation;
   smoking
ID LUNG-VOLUME-REDUCTION; FORCED EXPIRATORY VOLUME; GENOME-WIDE
   ASSOCIATION; CHRONIC-BRONCHITIS; ACUTE EXACERBATIONS; FOLLOW-UP;
   PNEUMOCOCCAL VACCINATION; FLUTICASONE PROPIONATE;
   CARDIOVASCULAR-DISEASE; DYNAMIC HYPERINFLATION
AB The global prevalence of physiologically defined chronic obstructive pulmonary disease (COPD) in adults aged >40 yr is approximately 9-10 per cent. Recently, the Indian Study on Epidemiology of Asthma, Respiratory Symptoms and Chronic Bronchitis in Adults had shown that the overall prevalence of chronic bronchitis in adults >35 yr is 3.49 per cent. The development of COPD is multifactorial and the risk factors of COPD include genetic and environmental factors. Pathological changes in COPD are observed in central airways, small airways and alveolar space. The proposed pathogenesis of COPD includes proteinase-antiproteinase hypothesis, immunological mechanisms, oxidant-antioxidant balance, systemic inflammation, apoptosis and ineffective repair. Airflow limitation in COPD is defined as a postbronchodilator FEV1 (forced expiratory volume in 1 sec) to FVC (forced vital capacity) ratio <0.70. COPD is characterized by an accelerated decline in FEV1. Co morbidities associated with COPD are cardiovascular disorders (coronary artery disease and chronic heart failure), hypertension, metabolic diseases (diabetes mellitus, metabolic syndrome and obesity), bone disease (osteoporosis and osteopenia), stroke, lung cancer, cachexia, skeletal muscle weakness, anaemia, depression and cognitive decline. The assessment of COPD is required to determine the severity of the disease, its impact on the health status and the risk of future events (e.g., exacerbations, hospital admissions or death) and this is essential to guide therapy. COPD is treated with inhaled bronchodilators, inhaled corticosteroids, oral theophylline and oral phosphodiesterase-4 inhibitor. Non pharmacological treatment of COPD includes smoking cessation, pulmonary rehabilitation and nutritional support. Lung volume reduction surgery and lung transplantation are advised in selected severe patients. Global strategy for the diagnosis, management and prevention of Chronic Obstructive Pulmonary Disease guidelines recommend influenza and pneumococcal vaccinations.
C1 [Vijayan, V. K.] Univ Delhi, Vallabhbhai Patel Chest Inst, Delhi 110007, India.
C3 University of Delhi
RP Vijayan, VK (corresponding author), Bhopal Mem Hosp & Res Ctr, Raisen By Rd, Bhopal 462038, India.
EM vijayanvk@hotmail.com
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TC 99
Z9 116
U1 1
U2 38
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, 400059, INDIA
SN 0971-5916
J9 INDIAN J MED RES
JI Indian J. Med. Res.
PD FEB
PY 2013
VL 137
BP 251
EP 269
PG 19
WC Immunology; Medicine, General & Internal; Medicine, Research &
   Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; General & Internal Medicine; Research & Experimental
   Medicine
GA AA1JJ
UT WOS:000330852200004
PM 23563369
DA 2025-06-11
ER

PT J
AU Kim, SC
   Kim, SW
   Chung, YJ
AF Kim, Sae-Chul
   Kim, Sang Wook
   Chung, Yun Jae
TI Men's health in South Korea
SO ASIAN JOURNAL OF ANDROLOGY
LA English
DT Review
DE Health; men; South Korea
ID URINARY-TRACT SYMPTOMS; BENIGN PROSTATIC HYPERPLASIA; HELP-SEEKING
   PATTERNS; AGED 40-80 YEARS; METABOLIC SYNDROME; PREVALENCE; ADULTS;
   EPIDEMIOLOGY; HYPERTENSION; DYSFUNCTION
AB Over the last four decades, rapid industrialisation and a Westernized lifestyle have changed disease patterns in South Korea. This study was conducted to review the current state of men's health in South Korea. By reviewing reports of government authorities and domestic and foreign studies related to men's health, we found that in men >= 65 years of age, 28.4% considered their health status good, whereas 38.3% considered their health status poor. The prevalence of moderate-to-severe lower urinary tract symptoms was similar to that in Caucasians. The prevalence of erectile dysfunction was higher than the global average. The incidence of cryptorchidism and hypospadias showed a tendency towards increase. The prevalence of diabetes mellitus continuously increased by 10.8% in 2008 and was the fifth leading cause of death in 2008. The prevalence of obesity increased from 26.0% in 1998 to 31.7% in 2007. The prevalence of ischaemic heart disease has continuously increased, with heart diseases causing one of every 12 deaths. The prevalence of chronic obstructive pulmonary disease in 2005 was 17.2% among adults >= 45 years of age. The top five prevalent cancers in men, in descending order, were cancers of the stomach, lung, liver, large bowel and prostate, among which the incidence of stomach, lung and liver cancers decreased by 0.7%, 0.6% and 2.2%, respectively, from 1999 to 2007, whereas the incidence of large bowel and prostate cancers increased by 7.0% and 13.2%, respectively. The prevalence of depression, dementia and sleep disorders was estimated as 17.3%, 4.21% and 20.2%, respectively. Together, these findings suggest that disease patterns in South Korean men are becoming Westernized. Asian Journal of Andrology (2011) 13, 519-525; doi: 10.1038/2010.134; published online 11 April 2011
C1 [Kim, Sae-Chul; Kim, Sang Wook; Chung, Yun Jae] Chung Ang Univ, Coll Med, Dept Urol & Internal Med, Seoul 156755, South Korea.
C3 Chung Ang University; Chung Ang University Hospital
RP Kim, SC (corresponding author), Chung Ang Univ, Coll Med, Dept Urol & Internal Med, Seoul 156755, South Korea.
EM saeckim@unitel.co.kr
RI Kim, Sang-Hyun/J-5402-2012
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NR 63
TC 9
Z9 9
U1 0
U2 10
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, 400059, INDIA
SN 1008-682X
EI 1745-7262
J9 ASIAN J ANDROL
JI Asian J. Androl.
PD JUL
PY 2011
VL 13
IS 4
BP 519
EP 525
DI 10.1038/2010.134
PG 7
WC Andrology; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Urology & Nephrology
GA 786PZ
UT WOS:000292321700003
PM 21478896
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Tafari, S
   Jesudason, D
   Wittert, GA
AF Tafari, Sam
   Jesudason, David
   Wittert, Gary A.
TI "Before you go"-considering genitourinary symptoms as a sentinel
   indicator of the presence of, or risk for, chronic disorders in men
SO JOURNAL OF MENS HEALTH
LA English
DT Article
DE Lower urinary tract symptoms; Nocturia; Erectile dysfunction;
   Cardiovascular disease; Diabetes; Sleep apnoea; Lifestyle; Metabolic
   syndrome; Men's health
ID URINARY-TRACT SYMPTOMS; QUALITY-OF-LIFE; ERECTILE DYSFUNCTION;
   HELP-SEEKING; ALCOHOL-CONSUMPTION; CIGARETTE-SMOKING; PHYSICAL-ACTIVITY;
   NATIONAL-HEALTH; YOUNG MEN; PREVALENCE
AB Men have a significantly shorter life expectancy compared to women, with disparities further magnified among those from disadvantaged backgrounds. Non-communicable diseases (NCDs) constitute a large proportion of the health disparity between men and women. Up to 40% of the chronic disease burden in men could be mitigated through risk factor management or early intervention. This disparity is often attributed to the engagement with primary and preventive healthcare by men which is influenced by health literacy, accessibility of care and socio-economic status. The manuscript proposes that genitourinary symptoms, specifically erectile dysfunction (ED) and lower urinary tract symptoms (LUTS), are sentinel indicators of chronic diseases or their risk factors in men. LUTS and ED share risk factors with major chronic disorders like cardiovascular disease, diabetes, and obesity, and are associated with depression and obstructive sleep apnea. Both ED and LUTS are meaningful to men and can motivate seeking care, providing healthcare providers an opportunity for preventative measures and early treatment. Such an approach also ameliorates the LUTS and ED symptoms and substantially improves quality of life. We advocate for a targeted approach that uses ED and nocturia as entry points for engaging men in healthcare. This involves public health education to raise awareness about the significance of these symptoms and encouraging healthcare providers to actively inquire about them during consultations. By addressing these symptoms, healthcare practitioners can better identify and treat underlying chronic conditions early, potentially reducing morbidity and mortality among men and helping to narrow the sex related health outcome disparities between genders.
C1 [Tafari, Sam] Royal Adelaide Hosp, Endocrine & Metab Unit, Adelaide, SA 5000, Australia.
   [Tafari, Sam] South Australian Hlth & Med Res Inst, Adelaide, SA 5000, Australia.
   [Jesudason, David] Queen Elizabeth Hosp, Endocrine Dept, Woodville, SA 5011, Australia.
   [Jesudason, David] Univ Adelaide, Adelaide 5000, Australia.
   [Jesudason, David] Basil Hetzel Inst, Woodville, SA 5011, Australia.
   [Wittert, Gary A.] South Australian Hlth & Med Res Inst, Freemasons Ctr Male Hlth & Wellbeing, Adelaide, SA 5000, Australia.
   [Wittert, Gary A.] Univ Adelaide, Adelaide, SA 5000, Australia.
C3 Royal Adelaide Hospital; South Australian Health & Medical Research
   Institute (SAHMRI); University of Adelaide; Basil Hetzel Institute;
   South Australian Health & Medical Research Institute (SAHMRI);
   University of Adelaide
RP Tafari, S (corresponding author), Royal Adelaide Hosp, Endocrine & Metab Unit, Adelaide, SA 5000, Australia.; Tafari, S (corresponding author), South Australian Hlth & Med Res Inst, Adelaide, SA 5000, Australia.
EM sam.tafari@sa.gov.au
RI wittert, gary/AAE-2398-2019
FU Hospital Research Foundation
FX ST is funded by the Hospital Research Foundation and Freema-sons Centre
   for Male Health and Wellbeing.
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NR 100
TC 0
Z9 0
U1 1
U2 4
PU MRE PRESS
PI SINGAPORE
PA 14 ROBINSON RD #08-01A FAR EAST FINANCE, SINGAPORE, SINGAPORE
SN 1875-6867
EI 1875-6859
J9 J MENS HEALTH
JI J. Mens Health
PD SEP
PY 2024
VL 20
IS 9
BP 10
EP 16
DI 10.22514/jomh.2024.122
EA AUG 2024
PG 7
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA I0H5X
UT WOS:001292025200001
OA gold
DA 2025-06-11
ER

PT J
AU Simon, MS
   Barton, BB
   Glocker, C
   Musil, R
AF Simon, Maria S.
   Barton, Barbara B.
   Glocker, Catherine
   Musil, Richard
TI A comprehensive approach to predicting weight gain and therapy response
   in psychopharmacologically treated major depressed patients: A cohort
   study protocol
SO PLOS ONE
LA English
DT Article
ID METABOLIC SYNDROME; MYOCARDIAL-INFARCTION; SYMPTOMATOLOGY;
   QUESTIONNAIRE; ASSOCIATIONS; INFLAMMATION; OLANZAPINE; MICROBIOTA;
   INVENTORY; SEVERITY
AB Background A subgroup of patients with Major Depressive Disorder shows signs of low-grade inflammation and metabolic abberances, while antidepressants can induce weight gain and subsequent metabolic disorders, and lacking antidepressant response is associated with inflammation.
   Objectives A comprehensive investigation of patient phenotypes and their predictive capability for weight gain and treatment response after psychotropic treatment will be performed. The following factors will be analyzed: inflammatory and metabolic markers, gut microbiome composition, lifestyle indicators (eating behavior, physical activity, chronotype, patient characteristics (childhood adversity among others), and polygenic risk scores.
   Methods Psychiatric inpatients with at least moderate Major Depressive Disorder will be enrolled in a prospective, observational, naturalistic, monocentric study using stratified sampling. Ethical approval was obtained. Primary outcomes at 4 weeks will be percent weight change and symptom score change on the Montgomery Asberg Depression Rating Scale. Both outcomes will also be binarized into clinically relevant outcomes at 5% weight gain and 50% symptom score reduction. Predictors for weight gain and treatment response will be tested using multiple hierachical regression for continuous outcomes, and multiple binary logistic regression for binarized outcomes. Psychotropic premedication, current medication, eating behavior, baseline BMI, age, and sex will be included as covariates. Further, a comprehensive analysis will be carried out using machine learning. Polygenic risk scores will be added in a second step to estimate the additional variance explained by genetic markers. Sample size calculation yielded a total amount of N = 171 subjects.
   Discussion Patient and physician expectancies regarding the primary outcomes and non-random sampling may affect internal validity and external validity, respectively. Through the prospective and naturalistic design, results will gain relevance to clinical practice. Examining the predictive value of patient profiles for weight gain and treatment response during pharmacotherapy will allow for targeted adjustments before and concomitantly to the start of treatment.
C1 [Simon, Maria S.; Barton, Barbara B.; Glocker, Catherine; Musil, Richard] Ludwig Maximilians Univ Munchen, Univ Hosp, Dept Psychiat & Psychotherapy, Munich, Germany.
C3 University of Munich
RP Simon, MS (corresponding author), Ludwig Maximilians Univ Munchen, Univ Hosp, Dept Psychiat & Psychotherapy, Munich, Germany.
EM Maria.Simon@med.uni-muenchen.de
RI Musil, Richard/AAF-4331-2020
OI Musil, Richard/0000-0002-0792-8413; Simon, Maria
   Susanne/0000-0002-3437-2772
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NR 60
TC 4
Z9 4
U1 0
U2 4
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JUL 21
PY 2022
VL 17
IS 7
AR e0271793
DI 10.1371/journal.pone.0271793
PG 13
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 7T4CW
UT WOS:000911392100257
PM 35862413
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Yang, CJ
   Wang, HY
   Chou, TC
   Chang, CJ
AF Yang, Chia-Jui
   Wang, Hsiu-Yin
   Chou, Tse-Chih
   Chang, Chee-Jen
TI Prevalence and related drug cost of comorbidities in HIV-infected
   patients receiving highly active antiretroviral therapy in Taiwan: A
   cross-sectional study
SO JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
LA English
DT Article
DE Cost-burden; Epidemiology; Healthcare; Prevention; Taiwan
ID RITONAVIR-BOOSTED ATAZANAVIR; QUALITY-OF-LIFE; CARDIOVASCULAR-DISEASE;
   CUMULATIVE EXPOSURE; METABOLIC SYNDROME; RISK; TENOFOVIR
AB Background: To determine the prevalence of chronic comorbidities and associated medication costs in Taiwanese HIV patients in order to increase awareness of the disease burden among healthcare providers and patients.
   Methods: HIV-diagnosed patients receiving highly active antiretroviral therapy (HAART; 2010-2013) were identified from the Taiwan National Health Insurance Research Database with the corresponding International Classification of Diseases, ninth revision (ICD-9) code. Comorbidities (type II diabetes mellitus, hypertension, dyslipidemia, major depressive disorder, acute coronary syndrome, and cholelithiasis/nephrolithiasis) were identified according to ICD-9 or relevant medication use. Comorbidity medication and associated costs were identified using the drug classification code from the Anatomical Therapeutic Chemical classification system code series and series outpatient prescriptions.
   Results: Of 20,726 HIV-diagnosed Taiwanese patients (2010-2013), 13,142 receiving HAART were analyzed. Prevalence of all chronic comorbidities was significantly greater (p < 0.0001) in patients aged >= 40 years versus <40 years (diabetes mellitus, 14.95% vs. 3.30%; hypertension, 46.73% vs. 26.83%; dyslipidemia, 34.93% vs. 18.37%; depression, 23.75% vs. 19.88%; acute coronary syndrome, 1.16% vs. 0.21%; nephrolithiasis/cholelithiasis, 7.26% vs. 4.56%; >2 comorbidities, 24.80% vs. 7.21%). An increase in comorbidity medication spending (2010 vs. 2013 medication costs) was observed (antidyslipidemia, $88,878 vs. $168,180; antihyperglycemia, $32,372 vs. $73,518; antidepressants, $78,220 vs. $125,971; sedatives, $60,009 vs. $85,055; antihypertension, $47,115 vs. $95,134), contributing to overall treatment costs increasing almost two-fold from 2010 to 2013.
   Conclusions: Among HIV-infected Taiwanese patients receiving HAART, significant increases in comorbidity prevalence with age, along with rising comorbidity medication costs, suggest the need for preventative as well as chronic care. Copyright (C) 2019, Taiwan Society of Microbiology. Published by Elsevier Taiwan LLC.
C1 [Yang, Chia-Jui] Far Eastern Mem Hosp, Dept Internal Med, New Taipei, Taiwan.
   [Yang, Chia-Jui] Natl Yang Ming Univ, Sch Med, Taipei, Taiwan.
   [Wang, Hsiu-Yin] Janssen Pharmaceut, Med Affairs, Taipei, Taiwan.
   [Chou, Tse-Chih; Chang, Chee-Jen] Chang Gung Univ, Clin Informat & Med Stat Res Ctr, Taoyuan, Taiwan.
   [Chang, Chee-Jen] Chang Gung Univ, Grad Inst Clin Med Sci, 259,Wenhua 1st Rd, Taoyuan, Taiwan.
C3 Far Eastern Memorial Hospital; National Yang Ming Chiao Tung University;
   Johnson & Johnson; Janssen Pharmaceuticals; Chang Gung University; Chang
   Gung University
RP Chang, CJ (corresponding author), Chang Gung Univ, Grad Inst Clin Med Sci, 259,Wenhua 1st Rd, Taoyuan, Taiwan.
EM cjchang@mail.cgu.edu.tw
RI Yang, Chia Jui/HSG-0777-2023
OI Yang, Chia Jui/0000-0002-5925-2064
FU Janssen Pharmaceuticals, Taiwan
FX This work was sponsored by Janssen Pharmaceuticals, Taiwan.
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NR 40
TC 10
Z9 11
U1 0
U2 6
PU ELSEVIER TAIWAN
PI TAIPEI
PA RM N-412, 4F, CHIA HSIN BUILDING 11, NO 96, ZHONG SHAN N ROAD SEC 2,
   TAIPEI, 10449, TAIWAN
SN 1684-1182
EI 1995-9133
J9 J MICROBIOL IMMUNOL
JI J. Microbiol. Immunol. Infect.
PD OCT
PY 2019
VL 52
IS 5
BP 720
EP 727
DI 10.1016/j.jmii.2019.05.011
PG 8
WC Immunology; Infectious Diseases; Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Infectious Diseases; Microbiology
GA JA6PA
UT WOS:000487963100006
PM 31358463
OA gold
DA 2025-06-11
ER

PT J
AU Lin, CH
   Kuo, CC
   Chou, LS
   Chen, YH
   Chen, CC
   Huang, KH
   Lane, HY
AF Lin, Ching-Hua
   Kuo, Chao-Chan
   Chou, Li-Shiu
   Chen, Yeng-Hung
   Chen, Cheng-Chung
   Huang, Kuo-Hao
   Lane, Hsien-Yuan
TI A Randomized, Double-Blind Comparison of Risperidone Versus Low-Dose
   Risperidone Plus Low-Dose Haloperidol in Treating Schizophrenia
SO JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
LA English
DT Article
DE antipsychotic drug combination; schizophrenia; haloperidol; risperidone
ID RECEPTOR OCCUPANCY; SCHIZOAFFECTIVE DISORDER; PROLACTIN LEVELS;
   OLANZAPINE; CLOZAPINE; SCALE; ANTIPSYCHOTICS; POLYPHARMACY; QUETIAPINE;
   MULTIPLE
AB Monotherapy is recommended for schizophrenia treatment, but the risk-benefit issue of antipsychotic drug combination (except for clozapine) remains unclear. Risperidone, an atypical antipsychotic drug, has a lower incidence of extrapyramidal syndrome but higher risks of prolactinemia and metabolic syndrome than haloperidol, a typical agent. This study compared efficacy and safety of risperidone monotherapy versus low-dose risperidone plus low-dose haloperidol in schizophrenia. In this 6-week, double-blind study, patients were randomized to the combination group (2-mg/d risperidone plus 2-mg/d haloperidol, n = 46) or the monotherapy group (4-mg/d risperidone, n = 42). Efficacy assessments included Clinical Global Impression-Severity, Positive and Negative Syndrome Scale and subscales, Calgary Depression Scale, Global Assessment of Functioning, and Medical Outcomes Study Short-Form 36. Safety was rigorously monitored. Response was defined as 30% reduction in the Positive and Negative Syndrome Scale total score. The 2 treatment groups were similar in (1) demographic and clinical characteristics at baseline, (2) response rate, and (3) improvement in various psychopathological measures and quality of life at end point. The monotherapy group had a higher increase in prolactin levels (P = 0.04) and Simpson-Angus Scale scores (P = 0.04) and a higher percentage of biperiden use (P = 0.045). There were no significant between-group difference in changes in weight, vital signs, corrected QT interval, liver/renal function, fasting glucose level, and lipid profiles. The findings suggest that risperidone monotherapy may yield higher prolactin levels than a combination of low-dose risperidone plus low-dose haloperidol. The 2 treatment groups are similar in efficacy, life quality, and other safety profiles. Future long-term studies are warranted.
C1 [Huang, Kuo-Hao; Lane, Hsien-Yuan] China Med Univ Hosp, Dept Psychiat, Taichung 404, Taiwan.
   [Lane, Hsien-Yuan] China Med Univ Hosp, Inst Clin Med Sci, Taichung 404, Taiwan.
   [Lane, Hsien-Yuan] Sunshine Psychiat Hosp, Taichung, Taiwan.
   [Chen, Cheng-Chung] Kaohsiung Med Univ, Dept Psychiat, Kaohsiung, Taiwan.
   [Lin, Ching-Hua] Kaohsiung Med Univ, Grad Inst Med, Kaohsiung, Taiwan.
   [Lin, Ching-Hua; Kuo, Chao-Chan; Chou, Li-Shiu; Chen, Yeng-Hung; Chen, Cheng-Chung] Kai Suan Psychiat Hosp, Kaohsiung, Taiwan.
C3 China Medical University Taiwan; China Medical University Hospital -
   Taiwan; China Medical University Taiwan; China Medical University
   Hospital - Taiwan; Kaohsiung Medical University; Kaohsiung Medical
   University
RP Lane, HY (corresponding author), China Med Univ Hosp, Dept Psychiat, 2 Yuh Rd, Taichung 404, Taiwan.
EM hylane@pchome.com.tw
RI chang, hao/JNF-0325-2023; Chen, Xuebin/AAP-8042-2020
FU National Science Council (Taiwan [NSC-97-2314-B-039-006-MY3,
   NSC-98-2627-B-039-001]; National Health Research Institutes (Taiwan)
   [NHRI-EX-98-9405PI]; Department of Health (Taiwan)
   [DOH99-TD-I-111-TM001]; Taiwan, Department of Health Clinical Trial and
   Research Center of Excellence [DOH99-TD-B-111-004]; China Medial
   University Hospital (Taiwan) [DMR-98-093, DMR-98-094]
FX This study was funded by the Kai-Suan Psychiatry Hospital in 2007-2009,
   the National Science Council (Taiwan) NSC-97-2314-B-039-006-MY3, and
   NSC-98-2627-B-039-001, National Health Research Institutes (Taiwan)
   NHRI-EX-98-9405PI, Department of Health (Taiwan) DOH99-TD-I-111-TM001,
   Taiwan, Department of Health Clinical Trial and Research Center of
   Excellence (DOH99-TD-B-111-004), and China Medial University Hospital
   (Taiwan) DMR-98-093 and DMR-98-094.
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NR 48
TC 29
Z9 29
U1 0
U2 12
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0271-0749
EI 1533-712X
J9 J CLIN PSYCHOPHARM
JI J. Clin. Psychopharmacol.
PD OCT
PY 2010
VL 30
IS 5
BP 518
EP 525
DI 10.1097/JCP.0b013e3181f28dff
PG 8
WC Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Psychiatry
GA 650JY
UT WOS:000281846400006
PM 20814315
DA 2025-06-11
ER

PT J
AU Alihanoglu, YI
   Yildiz, BS
   Kilic, ID
   Uludag, B
   Demirci, EE
   Zungur, M
   Evrengul, H
   Kaftan, AH
AF Alihanoglu, Yusuf I.
   Yildiz, Bekir S.
   Kilic, I. Dogu
   Uludag, Burcu
   Demirci, Emre E.
   Zungur, Mustafa
   Evrengul, Harun
   Kaftan, Asuman H.
TI Impaired Systolic Blood Pressure Recovery and Heart Rate Recovery After
   Graded Exercise in Patients With Metabolic Syndrome
SO MEDICINE
LA English
DT Article
ID CORONARY-ARTERY-DISEASE; MIDDLE-AGED MEN; CARDIOVASCULAR-DISEASE;
   MYOCARDIAL-INFARCTION; MORTALITY; RISK; INDIVIDUALS; DYSFUNCTION;
   PREDICTOR; FITNESS
AB The aim of this study was to evaluate and compare systolic blood pressure recovery and heart rate recovery (HRR) values obtained at various time intervals after maximal graded exercise treadmill testing between patients with metabolic syndrome (MS) and the controls without MS. To our knowledge, this is the first study indicating systolic blood pressure recovery (SBPR) impairment and its relations to HRR and other variables in this group of patients.
   The study population included 110 patients with MS (67 men, 43 women; mean age: 46 +/- 9 years) and 110 control subjects who did not meet the criteria for MS (58 men, 52 women; mean age: 44 +/- 10 years). All patients were selected from nonobese, apparently healthy sedentary individuals who had the ability to perform maximum exercise testing. SBPR was assessed by calculating the ratio of systolic blood pressure (SBP) obtained in the third minute of the recovery period to either the peak-exercise SBP or the SBP in the first minute of the recovery period after graded exercise testing. HRR values were calculated by subtracting the HR at the first, second, third, fourth, and fifth minutes of the recovery period from the HR reached at peak exercise.
   There was no significant difference found between the 2 groups with respect to age and sex distribution. As expected, patients with MS had higher waist circumference, fasting plasma glucose and serum triglyceride, and lower high-density lipoprotein cholesterol compared with control subjects. All HRR values calculated in the first, second, third, fourth, and fifth minutes were significantly detected lower in the MS group compared with the control group (HRR 1st: 32 +/- 10 vs 36 +/- 11; P = 0.009; HRR 2nd: 47 +/- 10 vs 51 +/- 11; P = 0.02; HRR 3rd: 53 +/- 11 vs 58 +/- 12; P = 0.001; HRR 4th: 57 +/- 11 vs 64 +/- 12; P < 0.001; HRR 5th: 60 +/- 16 vs 69 +/- 15; P < 0.001). In addition, calculated mean values for SBPR1 and SBPR2 were > 1 in patients with MS (1.01 +/- 0.2 vs 0.91 +/- 0.1 and 1.01 +/- 0.1 vs 0.94 +/- 0.1) and these were statistically significant compared with the control group (P < 0.001 and P = 0.002, respectively). The existence of MS was found to be the only parameter that was independently and positively related to SBPR values in the study population.
   Our findings suggest that only the existence of MS itself, not the presence of any MS components, is independently associated with SBPRs. We are of the opinion that significantly impaired SBPR values, in addition to the decreased HRR values observed in this group of patients, such as those with MS, may especially help identify patients with potentially increased cardiovascular risk despite normal exercise stress testing findings.
C1 [Alihanoglu, Yusuf I.; Yildiz, Bekir S.; Kilic, I. Dogu; Uludag, Burcu; Demirci, Emre E.; Evrengul, Harun; Kaftan, Asuman H.] Pamukkale Univ, Fac Med, Dept Cardiol, TR-20070 Denizli, Turkey.
   [Zungur, Mustafa] Sifa Univ, Fac Med, Dept Cardiol, Izmir, Turkey.
C3 Pamukkale University; Sifa University
RP Alihanoglu, YI (corresponding author), Pamukkale Univ, Fac Med, Dept Cardiol, TR-20070 Denizli, Turkey.
EM aliizyu@mynet.com
RI YILDIZ, Bekir serhat/HPF-3823-2023; Uludağ, Burcu/HTT-2787-2023
OI ULUDAG, Burcu/0000-0003-2178-6308
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NR 37
TC 11
Z9 12
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD JAN
PY 2015
VL 94
IS 2
AR e428
DI 10.1097/MD.0000000000000428
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA AZ3QS
UT WOS:000348142400025
PM 25590851
OA Green Published, gold
DA 2025-06-11
ER

PT B
AU Deng, YF
   Scherer, PE
AF Deng, Yingfeng
   Scherer, Philipp E.
BE Powers, AC
   Ahima, RS
TI Adipokines as novel biomarkers and regulators of the metabolic syndrome
SO YEAR IN DIABETES AND OBESITY
SE Annals of the New York Academy of Sciences-Series
LA English
DT Article; Book Chapter
DE adipokine; adiponectin; adipose tissue; obesity; insulin resistance;
   inflammation
ID HUMAN ADIPOSE-TISSUE; ENDOPLASMIC-RETICULUM STRESS; BODY-MASS INDEX;
   MESSENGER-RNA EXPRESSION; SERUM ADIPONECTIN LEVELS; SOLUBLE LEPTIN
   RECEPTOR; DIET-INDUCED OBESITY; FREE FATTY-ACIDS; NF-KAPPA-B;
   INSULIN-RESISTANCE
AB Over the past two decades our view of adipose tissue has undergone a dramatic change from an inert energy storage tissue to an active endocrine organ. Adipose tissue communicates with other central and peripheral organs by synthesis and secretion of a host of molecules that we generally refer to as adipokines. The levels of some adipokines correlate with specific metabolic states and have the potential to impact directly upon the metabolic homeostasis of the system. A dysregulation of adipokines has been implicated in obesity, type 2 diabetes, hypertension, cardiovascular disease, and an ever-growing larger list of pathological changes in a number of organs. Here, we review the recent progress regarding the synthesis, secretion, and physiological function of adipokines with perspectives on future directions and potential therapeutic goals.
   Adipose tissue has been recognized as an active endocrine organ in addition to its role as the main storage depot for triglycerides.1 An increasing number of adipocyte-derived secretory factors ("adipokines") are described in the literature,2,3 highlighting the central role of adipose tissue in regulating whole body energy homeostasis, not only by partitioning lipids into various depots, but also through adipokine-mediated modulation of a number of signaling cascades in target tissues. It is well-established that individuals that are obese and/or suffer from the metabolic syndrome display a characteristic imbalance of their adipokine profile. This altered adipokine profile leads to profound changes in insulin sensitivity and other biochemical alterations of metabolites, making an individual more prone to metabolic disorders. Through their autocrine, paracrine, and endocrine functions, adipokines influence a number of organs critical for energy homeostasis. The changes in each individual adipokine are the result of a coordinated change of specific transcriptional programs that affect entire groups of adipocyte gene products as well as posttranslational mechanisms that affect the release of specific proteins differentially.
   Among these adipokines, adiponectin is one of the most potent molecules with respect to its insulin-sensitizing activity. However, unlike the vast majority of adipocyte-derived factors, the levels of adiponectin in circulation display an inverse correlation with adiposity. Given the established beneficial roles of adiponectin on whole body metabolism and its profound protective effects against many chronic diseases, a better understanding of the regulation of adiponectin secretion is very important. Here, we focus on the regulation of adiponectin secretion from the adipocyte as a paradigm of protein release from the secretory pathway of the adipocyte and the changes it undergoes in the context of obesity and other pathological settings. Beyond the mechanics of protein release, we will extend the discussion to other recent developments in the area of adipokines and their effects on metabolism.
C1 Univ Texas, SW Med Ctr, Touchstone Diabet Ctr, Dept Internal Med, Dallas, TX 75390 USA.
   Univ Texas, SW Med Ctr, Dept Cell Biol, Dallas, TX 75390 USA.
C3 University of Texas System; University of Texas Southwestern Medical
   Center Dallas; University of Texas Dallas; University of Texas System;
   University of Texas Southwestern Medical Center Dallas; University of
   Texas Dallas
RP Scherer, PE (corresponding author), Univ Texas, SW Med Ctr, Touchstone Diabet Ctr, Dept Internal Med, 5323 Harry Hines Blvd, Dallas, TX 75390 USA.
EM Philipp.Scherer@utsouthwestern.edu
RI Deng, Yingfeng/AAB-8962-2019; Scherer, Philipp/K-7819-2012
OI deng, yingfeng/0000-0003-1314-5105
FU NIH [R01-DK55758, RC1-DK086629, P01-DK088761, R01-CA112023]; ADA
   [7-08-MN-53]
FX This work was supported by NIH grants R01-DK55758, RC1-DK086629,
   P01-DK088761, and R01-CA112023 (PES). YD is supported by a post-doctoral
   fellowship from the ADA (7-08-MN-53). We thank Dr. Zhao Wang for helpful
   discussions.
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NR 203
TC 413
Z9 467
U1 1
U2 40
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER STREET, HOBOKEN, NJ, UNITED STATES
BN 978-1-57331-756-6
J9 ANN NY ACAD SCI
JI Ann.NY Acad.Sci.
PY 2010
VL 1212
BP E1
EP E19
DI 10.1111/j.1749-6632.2010.05875.x
PG 19
WC Endocrinology & Metabolism; Multidisciplinary Sciences
WE Book Citation Index – Science (BKCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Science & Technology - Other Topics
GA BTO16
UT WOS:000287463600011
PM 21276002
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Qian, SF
   Huang, TS
   Wen, QQ
   Zhang, YX
   Chen, J
   Feng, XB
AF Qian, Sifan
   Huang, Tiansheng
   Wen, Qiuqing
   Zhang, Yuxia
   Chen, Jing
   Feng, Xiaobin
TI Dynapenic abdominal obesity and the risk of depressive symptoms in
   middle-aged and older Chinese adults: Evidence from a national cohort
   study
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Dynapenic abdominal obesity; Handgrip strength; Abdominal obesity;
   Depressive symptoms
ID SARCOPENIC OBESITY; METABOLIC SYNDROME; MUSCLE STRENGTH; EXERCISE;
   HEALTH; WOMEN
AB Background: Population-based evidence on the relationship between dynapenic abdominal obesity and depressive symptoms is rare. We aimed to prospectively investigate the relationship between dynapenic abdominal obesity and depressive symptoms among middle-aged and older Chinese adults. Methods: A total of 9322 participants free of depressive symptoms in the China Health and Retirement Longitudinal Study were included. The participants were divided into four groups: non-dynapenic/non-abdominal obesity (ND/NAO), non-dynapenic/abdominal obesity (ND/AO), dynapenic/non-abdominal obesity (D/NAO) and dynapenic/abdominal obesity (D/AO) according to the sex-specific grip strength (<28 kg for men and <18 kg for women) and waist circumference (>= 85 cm for men and >= 80 cm for women) that in line with the Chinese criteria. Depressive symptoms was defined as a score of >= 12 for the 10-item Center for Epidemiological Studies Depression Scale. Logistic regression model was used to explore the association between dynapenic abdominal obesity and depressive symptoms. Results: After an approximately 3-year of follow-up, 1810 participants (19.4 %) developed depressive symptoms. The multivariable-adjusted odds ratio for the D/AO versus ND/NAO was 1.61 (95 % CI: 1.31-1.98) for depressive symptoms. In addition, this relationship was more profound in participants aged<60 years (OR = 2.27, 95 % CI: 1.60-3.22) than participants aged >= 60 (OR = 1.36, 95 % CI: 1.05-1.77; P-interaction = 0.04). However, dynapenic obesity (defined by body mass index) was not linked to depressive symptoms. Limitations: Causal link and residual confounding were not addressed because of the observational study design. Conclusions: Dynapenic abdominal obesity was associated with an increased risk of depressive symptoms, especially among those aged<60 years.
C1 [Qian, Sifan; Wen, Qiuqing] Huzhou Univ, Huzhou Municipal Hosp 3, Dept Publ Hlth, Affiliated Hosp, Huzhou, Zhejiang, Peoples R China.
   [Huang, Tiansheng] Soochow Univ, Med Coll, Sch Publ Hlth, Dept Epidemiol, Suzhou, Peoples R China.
   [Huang, Tiansheng] Soochow Univ, Jiangsu Key Lab Prevent & Translat Med Geriatr Dis, Med Coll, Suzhou, Peoples R China.
   [Zhang, Yuxia] Ctr Dis Prevent & Control Wujiang Dist, Suzhou, Peoples R China.
   [Chen, Jing] Huzhou Univ, Huzhou Municipal Hosp 3, Dept Neurol, Affiliated Hosp, 2088 Tiaoxi Rd East, Huzhou 313000, Zhejiang, Peoples R China.
   [Feng, Xiaobin] Huzhou Univ, Huzhou Municipal Hosp 3, Dept Tradit Chinese Med, Affiliated Hosp, 2088 Tiaoxi Rd East, Huzhou 313000, Zhejiang, Peoples R China.
C3 Huzhou University; Soochow University - China; Soochow University -
   China; Huzhou University; Huzhou University
RP Chen, J (corresponding author), Huzhou Univ, Huzhou Municipal Hosp 3, Dept Neurol, Affiliated Hosp, 2088 Tiaoxi Rd East, Huzhou 313000, Zhejiang, Peoples R China.; Feng, XB (corresponding author), Huzhou Univ, Huzhou Municipal Hosp 3, Dept Tradit Chinese Med, Affiliated Hosp, 2088 Tiaoxi Rd East, Huzhou 313000, Zhejiang, Peoples R China.
EM chenjing2@hz3rd-hosp.cn; xiaobin@hz3rd-hosp.cn
FU National Institute on Aging [R01 AG030153, RC2 AG036619, R03 AG043052]
FX This analysis uses data or information from the Harmonized CHARLS
   dataset and Codebook, Version D as of June 2021 developed by the Gateway
   to Global Aging Data. The development of the Harmonized CHARLS was
   funded by the National Institute on Aging (R01 AG030153, RC2 AG036619,
   R03 AG043052) . For more information, please refer to
   https://g2aging.org/.
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NR 50
TC 1
Z9 1
U1 6
U2 15
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD JUN 15
PY 2024
VL 355
BP 66
EP 72
DI 10.1016/j.jad.2024.03.115
EA MAR 2024
PG 7
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA RF9M6
UT WOS:001226370200001
PM 38548204
DA 2025-06-11
ER

PT J
AU Clayton, AH
   Goldstein, I
   Kim, NN
   Althof, SE
   Faubion, SS
   Faught, BM
   Parish, SJ
   Simon, JA
   Vignozzi, L
   Christiansen, K
   Davis, SR
   Freedman, MA
   Kingsberg, SA
   Kirana, PS
   Larkin, L
   McCabe, M
   Sadovsky, R
AF Clayton, Anita H.
   Goldstein, Irwin
   Kim, Noel N.
   Althof, Stanley E.
   Faubion, Stephanie S.
   Faught, Brooke M.
   Parish, Sharon J.
   Simon, James A.
   Vignozzi, Linda
   Christiansen, Kristin
   Davis, Susan R.
   Freedman, Murray A.
   Kingsberg, Sheryl A.
   Kirana, Paraskevi-Sofia
   Larkin, Lisa
   McCabe, Marita
   Sadovsky, Richard
TI The International Society for the Study of Women's Sexual Health Process
   of Care for Management of Hypoactive Sexual Desire Disorder in Women
SO MAYO CLINIC PROCEEDINGS
LA English
DT Review
ID SURGICALLY MENOPAUSAL WOMEN; COMBINED ORAL-CONTRACEPTIVES; MAJOR
   DEPRESSIVE DISORDER; VULVO-VAGINAL ATROPHY; BODY-MASS INDEX;
   QUALITY-OF-LIFE; POSTMENOPAUSAL WOMEN; PREMENOPAUSAL WOMEN; TESTOSTERONE
   PATCH; METABOLIC SYNDROME
AB The International Society for the Study of Women's Sexual Health process of care (POC) for management of hypoactive sexual desire disorder (HSDD) algorithm was developed to provide evidence-based guidelines for diagnosis and treatment of HSDD in women by health care professionals. Affecting 10% of adult females, HSDD is associated with negative emotional and psychological states and medical conditions including depression. The algorithm was developed using a modified Delphi method to reach consensus among the 17 international panelists representing multiple disciplines. The POC starts with the health care professional asking about sexual concerns, focusing on issues related to low sexual desire/interest. Diagnosis includes distinguishing between generalized acquired HSDD and other forms of low sexual interest. Biopsychosocial assessment of potentially modifiable factors facilitates initiation of treatment with education, modification of potentially modifiable factors, and, if needed, additional therapeutic intervention: sex therapy, central nervous system agents, and hormonal therapy, guided in part by menopausal status. Sex therapy includes behavior therapy, cognitive behavior therapy, and mindfulness. The only central nervous system agent currently approved by the US Food and Drug Administration (FDA) for HSDD is flibanserin in premenopausal women; use of flibanserin in postmenopausal women with HSDD is supported by data but is not FDA approved. Hormonal therapy includes off-label use of testosterone in postmenopausal women with HSDD, which is supported by data but not FDA approved. The POC incorporates monitoring the progress of therapy. In conclusion, the International Society for the Study of Women's Sexual Health POC for the management of women with HSDD provides a rational, evidence-based guideline for health care professionals to manage patients with appropriate assessments and individualized treatments. (C) 2017 Mayo Foundation for Medical Education and Research. Published by Elsevier Inc.
C1 [Clayton, Anita H.] Univ Virginia, Dept Psychiat & Behav Neurosci, Charlottesville, VA USA.
   [Clayton, Anita H.] Univ Virginia, Dept Obstet & Gynecol, Charlottesville, VA USA.
   [Goldstein, Irwin] Alvarado Hosp, Sexual Med Program, San Diego, CA USA.
   [Kim, Noel N.] Inst Sexual Med, 6330 Nancy Ridge Dr,Ste 102, San Diego, CA 92121 USA.
   [Althof, Stanley E.] Case Western Reserve Univ, Sch Med, Cleveland, OH USA.
   [Kingsberg, Sheryl A.] Case Western Reserve Univ, Sch Med, Dept Reprod Biol, Cleveland, OH 44106 USA.
   [Kingsberg, Sheryl A.] Case Western Reserve Univ, Sch Med, Dept Psychiat, Cleveland, OH 44106 USA.
   [Althof, Stanley E.] Ctr Marital & Sexual Hlth South Florida, W Palm Beach, FL USA.
   [Faubion, Stephanie S.] Mayo Clin, Div Gen Internal Med, Womens Hlth Clin, Rochester, MN USA.
   [Faught, Brooke M.] Womens Inst Sexual Hlth, Nashville, TN USA.
   [Parish, Sharon J.] Weill Cornell Med, Dept Psychiat, New York, NY USA.
   [Parish, Sharon J.] Weill Cornell Med, Dept Med, New York, NY USA.
   [Simon, James A.] George Washington Univ, Dept Obstet & Gynecol, Washington, DC USA.
   [Vignozzi, Linda] Univ Florence, Dept Biomed Expt & Clin Sci, Florence, Italy.
   [Christiansen, Kristin] Pk Nicollet Sexual Med & Male Infertil Clin, St Louis Pk, MN USA.
   [Davis, Susan R.] Monash Univ, Sch Publ Hlth & Prevent Med, Melbourne, Vic, Australia.
   [Freedman, Murray A.] Med Coll Georgia, Dept Obstet & Gynecol, Augusta, GA 30912 USA.
   [Kirana, Paraskevi-Sofia] Inst Study Urol Dis, Thessaloniki, Greece.
   [Larkin, Lisa] Lisa Larkin MD & Assoc, Mariemont, OH USA.
   [McCabe, Marita] Inst Hlth & Ageing, Melbourne, Vic, Australia.
   [Sadovsky, Richard] Suny Downstate Med Ctr, Dept Family Med, Brooklyn, NY 11203 USA.
C3 University of Virginia; University of Virginia; University System of
   Ohio; Case Western Reserve University; University System of Ohio; Case
   Western Reserve University; University System of Ohio; Case Western
   Reserve University; Mayo Clinic; Cornell University; Weill Cornell
   Medicine; Cornell University; Weill Cornell Medicine; George Washington
   University; University of Florence; Monash University; University System
   of Georgia; Augusta University; State University of New York (SUNY)
   System; SUNY Downstate Health Sciences University
RP Kim, NN (corresponding author), Inst Sexual Med, 6330 Nancy Ridge Dr,Ste 102, San Diego, CA 92121 USA.
EM noelkim@gmail.com
RI Davis, Susan/A-3111-2009
OI Vignozzi, Linda/0000-0003-0907-0630; Faught, Brooke/0000-0001-8294-1944;
   McCabe, Marita/0000-0002-4989-8582
FU International Society for the Study of Women's Sexual Health from
   Valeant Pharmaceuticals International, Inc; AMAG Pharmaceuticals;
   Emotional Brain BV; Palatin Technologies, Inc.
FX Funding for this project was provided by the International Society for
   the Study of Women's Sexual Health from unrestricted educational grants
   from Valeant Pharmaceuticals International, Inc, AMAG Pharmaceuticals,
   Emotional Brain BV, and Palatin Technologies, Inc.
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NR 196
TC 101
Z9 102
U1 1
U2 20
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0025-6196
EI 1942-5546
J9 MAYO CLIN PROC
JI Mayo Clin. Proc.
PD APR
PY 2018
VL 93
IS 4
BP 467
EP 487
DI 10.1016/j.mayocp.2017.11.002
PG 21
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA GB3TU
UT WOS:000428982400013
PM 29545008
OA hybrid, Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Shin, C
   Park, MH
   Han, CS
   Patkar, AA
   Ham, BJ
   Kim, SH
   Joe, SH
   Pae, CU
   Jung, IK
AF Shin, Cheolmin
   Park, Moon Ho
   Han, Changsu
   Patkar, Ashwin A.
   Ham, Byung Joo
   Kim, Seung-Hyun
   Joe, Sook-Haeng
   Pae, Chi-Un
   Jung, In-Kwa
TI Attitudes on clinical research participation of community living elders
   in Korea
SO ASIA-PACIFIC PSYCHIATRY
LA English
DT Article
DE attitude; clinical trial; elder; informed consent; survey
ID INFORMED-CONSENT; TRIALS; CAPACITIES; GUIDELINES; CANCER; PEOPLE; TOOL
AB Introduction The development of medical knowledge has involved increasing numbers of clinical studies, including trials of treatment modalities among elderly individuals. We evaluated knowledge about and attitudes on participation in various clinical trials among elderly individuals. Methods A semi-structured survey was developed and distributed to community-living elders who agreed to participate in the Ansan Geriatric Study. Survey items addressed (i) the process of acquiring consent, (ii) the advantages of participation in clinical trials, (iii) worries about participation, (iv) clinical field trials in which they would like to participate, and (v) reasons behind participation. Results A total of 361 individuals (158 women and 203 men, mean age 71.1 years) agreed to answer the survey about clinical trials. The reported advantages of participation in clinical trials were access to cost-free medication or interventions (44.9%), prevention or early diagnosis of possible future diseases (23.8%), diagnostic and laboratory tests at no charge (14.7%), and contribution to human wellbeing (13.3) The reported disadvantages were the possibility of side-effects from the new treatments (32.1%), giving blood for frequent laboratory tests (28.5%), concerns about intrusions on human dignity (9.9%), and possible leakage of personal identifying data (8.6%). An additional 10.8% saw no disadvantages. Subjects were interested in participating in clinical field trials for interventions or medication to treat metabolic syndrome and medical diseases (43.5%), Alzheimer's and Parkinson's diseases (11.1%), late-life depression (2.5%). Although more than two-thirds (77.3%) of the subjects believed that they should provide consent for themselves, some believed that their spouses (14.4%) or other family members (8.3%) should be able to receive the explanation of the clinical trial and sign the informed consent forms. Discussion We should consider the attitudes of elderly participants during the processes of explaining clinical trials and acquiring consent.
C1 [Shin, Cheolmin; Han, Changsu; Ham, Byung Joo; Kim, Seung-Hyun; Joe, Sook-Haeng; Jung, In-Kwa] Korea Univ, Coll Med, Dept Psychiat, Ansan Hosp, Ansan 425707, Gyunggi Do, South Korea.
   [Park, Moon Ho] Korea Univ, Coll Med, Dept Neurol, Seoul 136705, South Korea.
   [Park, Moon Ho; Han, Changsu] Korea Univ, Geriatr Hlth Clin, Seoul, South Korea.
   [Park, Moon Ho; Han, Changsu] Korea Univ, Res Inst, Seoul, South Korea.
   [Patkar, Ashwin A.; Pae, Chi-Un] Duke Univ, Med Ctr, Dept Behav Sci & Psychiat, Duhram, NC USA.
   [Pae, Chi-Un] Catholic Univ, Coll Med, Dept Psychiat, Seoul, South Korea.
C3 Korea University; Korea University Medicine (KU Medicine); Korea
   University; Korea University Medicine (KU Medicine); Korea University;
   Korea University; Duke University; Catholic University of Korea
RP Han, CS (corresponding author), Korea Univ, Coll Med, Dept Psychiat, Ansan Hosp, 516 Gojan Dong, Ansan 425707, Gyunggi Do, South Korea.
EM hancs@korea.ac.kr; pae@catholic.ac.kr
RI Shin, Cheolmin/AAX-7092-2020; Pae, Chi-Un/AAG-5752-2020; Ham,
   Byung-Joo/S-9982-2019; Han, Changsu/H-9926-2013
OI Han, Changsu/0000-0002-4021-8907; Park, Moon Ho/0000-0002-4892-3475;
   Ham, Byung Joo/0000-0002-0108-2058
FU Hanlim Pharmaceutical Co. [R0912281]
FX This study is partially supported by the educational research fund from
   Hanlim Pharmaceutical Co. to Korea University (No. R0912281).
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NR 20
TC 1
Z9 1
U1 0
U2 7
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1758-5864
J9 ASIA-PAC PSYCHIAT
JI Asia-Pac. Psychiatry
PD SEP
PY 2012
VL 4
IS 3
BP 168
EP 173
DI 10.1111/j.1758-5872.2012.00177.x
PG 6
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 994QN
UT WOS:000307946300003
DA 2025-06-11
ER

PT J
AU Blum, K
   Dennen, CA
   Lewandrowski, KU
   Sharafshah, A
   Pinhasov, A
   Bowirrat, A
   Elman, I
   Cadet, JL
   Braverman, ER
   Thanos, PK
   Makale, M
   Baron, D
   Ashford, JW
   Fuehrlein, B
   Avena, N
   Gardner, E
   Badgaiyan, RD
   Gondré-Lewis, M
   Modestino, EJ
   Khalsa, J
   Murphy, KT
   Sunder, K
   Foojan, Z
   Jafari, N
   Carney, PR
   Cortes, R
   Edwards, D
   Roy, AK III
   Smith, DE
   Gold, MS
AF Blum, Kenneth
   Dennen, Catherine A.
   Lewandrowski, Kai-Uwe
   Sharafshah, Alireza
   Pinhasov, Albert
   Bowirrat, Abdalla
   Elman, Igor
   Cadet, Jean Lud
   Braverman, Eric R.
   Thanos, Panayotis K.
   Makale, Milan
   Baron, David
   Ashford, J. Wesson
   Fuehrlein, Brian
   Avena, Nicole
   Gardner, Eliot
   Badgaiyan, Rajendra D.
   Gondre-Lewis, Marjorie
   Modestino, Edward J.
   Khalsa, Jag
   Murphy, Kevin T.
   Sunder, Keerthy
   Foojan, Zeine
   Jafari, Nicole
   Carney, Paul R.
   Cortes, Rene
   Edwards, Drew
   Iii, A. Kenison
   Smith, David E.
   Gold, Mark S.
TI Hypothesizing glucagon-like peptide 1 (GLP-1), agonists promote
   hypodopaminergia, resulting in heightened addictive reward-seeking and
   altered mood: Breaking the bubble and adding salt to a wound
SO MEDICAL HYPOTHESES
LA English
DT Article
DE Glucagon-Like Peptide 1 (GLP-1); Addiction; Substance Use Disorder
   (SUD); Suicidality; Metabolic Syndrome; Epigenetics; Genetics; Reward
   Deficiency Syndrome (RDS); Dopaminergic Dysregulation; Genetic Addiction
   Risk Severity (GARS)
ID DOPAMINE-RECEPTOR GENE; BODY-MASS INDEX; THYROID C-CELLS; DEFICIENCY
   SYNDROME; FOOD-INTAKE; METHADONE-MAINTENANCE; ACUTE-PANCREATITIS;
   STRUCTURAL BRAIN; OPIATE AGONISTS; ADVERSE EVENTS
AB Recent articles have suggested that the agonistic effects of GLP-1 in alcohol use disorder and substance use disorder are mediated centrally, partly through the downregulation of dopamine signaling. This hypothesis, from a consortium of multidisciplinary scientists and clinicians, explores the role of GLP-1 receptor agonists as compounds with broad antiaddiction properties. Short-term dopamine downregulation is relevant in treating metabolic disorders to reduce hyperdopaminergia, which increases insulin resistance and decreases insulin secretion. Single-nuclei transcriptomics and Fluorescent in situ Hybridization (FISH) studies revealed that GLP1Rs are expressed primarily on GABA neurons in the VTA. Scientists using in-vivo fiber photometry found that the efficacy of a systemic GLP-1R agonist to attenuate cocaine seeking was associated with increased activity of VTA GABA neurons and decreased activity of VTA dopamine neurons. However, to our knowledge, this is the first hypothesis to expose the potential of GLP-1 receptor agonists for heightened addictive reward-seeking behavior. Therefore, we caution against promoting chronic stimulation via GLP-1 agonists. Indeed, basic research findings have linked GLP-1 receptor agonists and several genes within the dopaminergic reward pathway. Therefore, stimulation of GLP-1 receptor agonists, especially chronically, can lead to the dysregulation of the dopaminergic pathway, which in turn can putatively cause depression, suicidality, and other mood disturbances. We therefore hypothesize that while employing GLP-1 agonism offers therapeutic benefits in instances of recognized hyperdopaminergia, it could be detrimemtal in patients with hypodopaminergia at risk for SUD.
C1 [Blum, Kenneth; Baron, David] Western Univ Hlth Sci, Ctr Exercise Sports, Div Addict Res & Educ, Mental Hlth, Lebanon, OR 97355 USA.
   [Blum, Kenneth; Baron, David] Western Univ Hlth Sci, Ctr Exercise Sports, Div Addict Res & Educ, Mental Hlth, Pomona, CA 91766 USA.
   [Blum, Kenneth] Eotvos Lorand Univ Budapest, Inst Psychol, Budapest, Hungary.
   [Blum, Kenneth] Wright State Univ, Boonshoft Sch Med, Dept Psychiat, Dayton, OH 45435 USA.
   [Blum, Kenneth] Univ Vermont, Coll Med, Dept Psychiat, Human Integrated Serv Unit,Ctr Clin & Translat Sc, Burlington, VT 05405 USA.
   [Blum, Kenneth] Sunder Fdn, Palm Springs, CA 92264 USA.
   [Blum, Kenneth; Murphy, Kevin T.] PEAKLOGIC LLC, Div Personalized Neuromodulat, Del Mar, CA 92130 USA.
   [Blum, Kenneth; Braverman, Eric R.] Kenneth Blum Inst Neurogenet & Behav, Div Nutrigen, Austin, TX 78701 USA.
   [Blum, Kenneth; Sharafshah, Alireza; Pinhasov, Albert; Bowirrat, Abdalla; Elman, Igor] Ariel Univ, Adelson Sch Med, Dept Mol Biol, Ariel, Israel.
   [Blum, Kenneth] PEAK LOG LLC, Div Personalized Neuromodulat, Del Mar, CA 92130 USA.
   [Blum, Kenneth; Sunder, Keerthy] Sunder Fdn, Div Personalized Med, Palm Springs, CA 92264 USA.
   [Dennen, Catherine A.] Jefferson Hlth Northeast, Dept Family Med, Philadelphia, PA 19114 USA.
   [Lewandrowski, Kai-Uwe] Fundacio Univ Sanitas, Dept Orthoped, Bogota, DC, Colombia.
   [Lewandrowski, Kai-Uwe] Ctr Adv Spine Care Southern Arizona, Div Personalized Pain Res & Educ, Tucson, AZ USA.
   [Sharafshah, Alireza] Guilan Univ Med Sci, Cellular & Mol Res Ctr, Sch Med, Rasht, Iran.
   [Elman, Igor] Harvard Coll Med, Dept Psychiat, Cambridge, MA USA.
   [Cadet, Jean Lud] NIDA, Mol Neuropsychiat Res Branch, Intramural Res Program, Baltimore, MD USA.
   [Thanos, Panayotis K.] SUNY Buffalo, Clin Res Inst Addict, Jacobs Sch Med & Biosci, Dept Pharmacol & Toxicol,Behav Neuropharmacol & N, Buffalo, NY USA.
   [Makale, Milan] Univ Calif San Diego, Dept Radiat Med & Appl Sci, La Jolla, CA USA.
   [Baron, David] Stanford Univ, Dept Psychiat, Sch Med, Palo Alto, CA USA.
   [Ashford, J. Wesson] Stanford Univ, Dept Psychiat & Behav Sci, Palo Alto, CA USA.
   [Ashford, J. Wesson] VA Palo Alto Hlth Care Syst, War Related Illness & Injury Study Ctr, Palo Alto, CA USA.
   [Fuehrlein, Brian] Yale Univ, Dept Psychiat, New Haven, CT USA.
   [Avena, Nicole] Icahn Sch Med St Sinai, Dept Neurosci, Mt Sinai, NY USA.
   [Gardner, Eliot] NIDA, Neuropsychopharmacol Sect, Intramural Res Program, Baltimore, MD USA.
   [Badgaiyan, Rajendra D.] Texas Tech Univ Hlth Sci, Sch Med, Dept Psychiat, Midland, TX USA.
   [Gondre-Lewis, Marjorie] Howard Univ, Coll Med, Dept Anat, Neuropsychopharmacol Lab, Washington, DC USA.
   [Braverman, Eric R.] Curry Coll, Dept Psychol, Milton, MA USA.
   [Khalsa, Jag] NIDA, Div Therapeut & Med Consequences, Med Consequences Drug Abuse & Infect Branch, NIH, 16071 Ind Dr, Gaithersburg, MD 20877 USA.
   [Khalsa, Jag] George Washington Univ, Sch Med, Dept Microbiol Immunol & Trop Med, Washington, DC USA.
   [Sunder, Keerthy] Univ Calif Riverside, Sch Med, Dept Psychiat, Riverside, CA USA.
   [Foojan, Zeine] Calif State Univ Long Beach, Dept Hlth Sci, Long Beach, CA USA.
   [Jafari, Nicole] Calif State Univ Long Beach, Dept Human Dev, Long Beach, CA USA.
   [Carney, Paul R.] Univ Missouri, Sch Med, Div Pediat Neurol, Columbia, MO USA.
   [Cortes, Rene] Univ Missouri, Child Hlth Res Inst, Sch Med, Dept Child Hlth, Columbia, MO USA.
   [Cortes, Rene] Univ Missouri, Sch Med, Dept Obstet Gynecol & Womens Hlth, Columbia, MO USA.
   [Edwards, Drew] Drew Edwards & Associates, Lakeview, FL USA.
   Tulane Univ, Tulane Sch Med, Dept Psychiat, New Orleans, LA USA.
   [Smith, David E.] Univ Calif San Francisco, Inst Hlth & Aging, San Francisco, CA USA.
   [Gold, Mark S.] Washington Univ, Dept Psychiat, Sch Med, St Louis, MO USA.
C3 Western University of Health Sciences; Eotvos Lorand University;
   University System of Ohio; Wright State University Dayton; University of
   Vermont; Ariel University; Guilan University of Medical Sciences;
   National Institutes of Health (NIH) - USA; NIH National Institute on
   Drug Abuse (NIDA); State University of New York (SUNY) System;
   University at Buffalo, SUNY; University of California System; University
   of California San Diego; Stanford University; Stanford University; US
   Department of Veterans Affairs; Veterans Health Administration (VHA); VA
   Palo Alto Health Care System; Yale University; National Institutes of
   Health (NIH) - USA; NIH National Institute on Drug Abuse (NIDA); Howard
   University; National Institutes of Health (NIH) - USA; NIH National
   Institute on Drug Abuse (NIDA); George Washington University; University
   of California System; University of California Riverside; California
   State University System; California State University Long Beach;
   California State University System; California State University Long
   Beach; University of Missouri System; University of Missouri Columbia;
   University of Missouri System; University of Missouri Columbia;
   University of Missouri System; University of Missouri Columbia; Tulane
   University; University of California System; University of California
   San Francisco; Washington University (WUSTL)
RP Blum, K (corresponding author), Western Univ Hlth Sci, Ctr Exercise Sports, Div Addict Res & Educ, Mental Hlth, Lebanon, OR 97355 USA.; Blum, K (corresponding author), Western Univ Hlth Sci, Ctr Exercise Sports, Div Addict Res & Educ, Mental Hlth, Pomona, CA 91766 USA.; Blum, K (corresponding author), Eotvos Lorand Univ Budapest, Inst Psychol, Budapest, Hungary.; Blum, K (corresponding author), Wright State Univ, Boonshoft Sch Med, Dept Psychiat, Dayton, OH 45435 USA.; Blum, K (corresponding author), Univ Vermont, Coll Med, Dept Psychiat, Human Integrated Serv Unit,Ctr Clin & Translat Sc, Burlington, VT 05405 USA.; Blum, K (corresponding author), Sunder Fdn, Palm Springs, CA 92264 USA.; Blum, K (corresponding author), PEAKLOGIC LLC, Div Personalized Neuromodulat, Del Mar, CA 92130 USA.; Blum, K (corresponding author), Kenneth Blum Inst Neurogenet & Behav, Div Nutrigen, Austin, TX 78701 USA.; Blum, K (corresponding author), Ariel Univ, Adelson Sch Med, Dept Mol Biol, Ariel, Israel.; Blum, K (corresponding author), PEAK LOG LLC, Div Personalized Neuromodulat, Del Mar, CA 92130 USA.; Blum, K (corresponding author), Sunder Fdn, Div Personalized Med, Palm Springs, CA 92264 USA.; Dennen, CA (corresponding author), Jefferson Hlth Northeast, Dept Family Med, Philadelphia, PA 19114 USA.
EM drd2gene@gmail.com; catherine.dennen@jefferson.edu
RI Braverman, Eric new/ABC-1152-2021; Gondre-Lewis, Marjorie/M-8055-2017;
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NR 230
TC 0
Z9 0
U1 2
U2 2
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0306-9877
EI 1532-2777
J9 MED HYPOTHESES
JI Med. Hypotheses
PD MAY
PY 2025
VL 198
AR 111612
DI 10.1016/j.mehy.2025.111612
PG 12
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 1IJ9A
UT WOS:001465752500001
DA 2025-06-11
ER

PT J
AU Brandt, EJ
   Garfein, J
   Pai, CW
   Bryant, J
   Kline-Rogers, E
   Fink, S
   Rubenfire, M
AF Brandt, Eric J.
   Garfein, Joshua
   Pai, Chih-Wen
   Bryant, Joseph
   Kline-Rogers, Eva
   Fink, Samantha
   Rubenfire, Melvyn
TI Identifying Factors for Low-Risk Participation in Alternative Cardiac
   Rehabilitation Models for Patients with Coronary Heart Disease Using
   MI'S SCOREPAD
SO CARDIOVASCULAR THERAPEUTICS
LA English
DT Article
ID PREVENTION; STATEMENT; NUTRITION; EXERCISE
AB Introduction. Although a recent joint society scientific statement (the American Association of Cardiovascular Pulmonary Rehabilitation, the American Heart Association, and the American College of Cardiology) suggests home-based cardiac rehab (CR) is appropriate for low- and moderate-risk patients, there are no paradigms to define such individuals with coronary heart disease. Methods. We reviewed a decade of data from all patients with coronary heart disease enrolled in a single CR center (University of Michigan) to identify the prevalence of low-risk factors, which may inform on consideration for participation in alternative models of CR. Low-risk factors included not having any of the following: metabolic syndrome, presence of implantable cardioverter defibrillator or permanent pacemaker, active smoking, prior stroke, congestive heart failure, obesity, advanced renal disease, poor exercise capacity, peripheral arterial disease, angina, or clinical depression (MI'S SCOREPAD). We report on the proportion of participants with these risk factors and the proportion with all of these low-risk factors. Results. The mean age of CR participants (n=1984) was 63 years; 25% were women, and 82% were non-Hispanic White. The mean number of low-risk factors was 8.5, which was similar in the 2011-2012 and 2018-2019 cohorts (8.5 vs. 8.3, respectively, P=0.08). Additionally, 9.3% of the 2011-2012 cohort and 7.6% of the 2018-2019 cohort had all 11 of the low-risk factors. Conclusion. In this observational study, we provide a first paradigm of identifying factors among coronary heart disease patients that may be considered low-risk and likely high-gain for participation in alternative models of CR. Further work is needed to track clinical outcomes in patients with these factors to determine thresholds for enrolling participants in alternative forms of CR.
C1 [Brandt, Eric J.; Garfein, Joshua; Pai, Chih-Wen; Bryant, Joseph; Kline-Rogers, Eva; Fink, Samantha; Rubenfire, Melvyn] Univ Michigan, Dept Internal Med, Div Cardiovasc Med, Ann Arbor, MI 48109 USA.
   [Brandt, Eric J.] Univ Michigan, Inst Healthcare Policy & Innovat, Ann Arbor, MI 48109 USA.
C3 University of Michigan System; University of Michigan; University of
   Michigan System; University of Michigan
RP Brandt, EJ (corresponding author), Univ Michigan, Dept Internal Med, Div Cardiovasc Med, Ann Arbor, MI 48109 USA.; Brandt, EJ (corresponding author), Univ Michigan, Inst Healthcare Policy & Innovat, Ann Arbor, MI 48109 USA.
EM ericjbrandtmd@gmail.com; jgarfein@umich.edu; cwpai@umich.edu;
   josebrya@umich.edu; evakline@umich.edu; smfink@umich.edu;
   mrubenfi@umich.edu
RI Brandt, Eric/AAH-1157-2019
OI Brandt, Eric/0000-0001-5463-4533
FU This research was funded by the University of Michigan Department of
   Internal Medicine, Ann Arbor, MI. Open Access funding is enabled and
   organized by BTAA 2023.; University of Michigan Department of Internal
   Medicine, Ann Arbor, MI
FX This research was funded by the University of Michigan Department of
   Internal Medicine, Ann Arbor, MI. Open Access funding is enabled and
   organized by BTAA 2023.
CR American Association of Cardiovascular and Pulmonary Rehabilitation, 2020, GUID CARD REH SEC PR
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NR 15
TC 2
Z9 2
U1 1
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1755-5914
EI 1755-5922
J9 CARDIOVASC THER
JI Cardiovasc. Ther.
PD SEP 8
PY 2023
VL 2023
AR 7230325
DI 10.1155/2023/7230325
PG 6
WC Cardiac & Cardiovascular Systems; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Pharmacology & Pharmacy
GA R8BT9
UT WOS:001066560900001
PM 37719172
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Kelly, RM
   Finn, J
   Healy, U
   Gallen, D
   Sreenan, S
   McDermott, JH
   Coogan, AN
AF Kelly, Rachael M.
   Finn, Jacinta
   Healy, Ultan
   Gallen, Dervla
   Sreenan, Seamus
   McDermott, John H.
   Coogan, Andrew N.
TI Greater social jetlag associates with higher HbA1c in adults with type 2
   diabetes: a cross sectional study
SO SLEEP MEDICINE
LA English
DT Article
DE Chronotype; Social jetlag; Personality; Glycemic control; HbA1c; Type 2
   diabetes
ID GLYCEMIC CONTROL; CIRCADIAN CLOCK; METABOLIC SYNDROME; HEMOGLOBIN A1C;
   SHIFT WORK; SLEEP; CHRONOTYPE; MISALIGNMENT; OBESITY; PERSONALITY
AB Background/Objectives: Later chronotype has been associated with poorer glycemic control in type 2 diabetes. It is unclear whether this is a direct relationship, or if personality factors or social jetlag ([SJL], ie, chronic circadian misalignment reflecting the discrepancy between the entrained phase of the circadian clock and socially-determined behavioural cycles) play a role. This study aimed to determine the relationships among chronotype, SJL, personality factors and glycemic control in type 2 diabetes, independently of sleep disturbances and daily caloric distribution.
   Methods: In sum, 252 type 2 diabetes patients attending an annual review outpatients' clinic completed questionnaires, including the Munich Chronotype Questionnaire to assess chronotype and SJL, the Pittsburgh Sleep Quality index (PSQI), the Big Five Personality Inventory and the Center for Epidemiologic Studies Depression Scale. Chart review provided information on diabetes duration, Hemoglobin A1c (HbA1c), body mass index (BMI) and other clinical variables. Caloric intake was assessed via 24-h dietary recall.
   Results: Hierarchical linear regression revealed that SJL, but not chronotype or personality factors, was a significant predictor of HbA1c levels beta = 0.16, p < 0.05). There was a significant relationship between later chronotype and HbA1c levels, but only in patients who had more than 90 min SJL (r = 0.51, p = 0.002). Younger age was associated with a higher HbA1c (r = -0.23, p < 0.001), and this effect was partially mediated through SJL (Pm = 0.22).
   Conclusions: We identify SJL as a novel factor that may impact on glycemic control in type 2 diabetes. Further study is needed to determine whether interventions aimed at reducing SJL may lead to improvements in glycemic control. (C) 2019 Elsevier B.V. All rights reserved.
C1 [Kelly, Rachael M.; Finn, Jacinta; Gallen, Dervla; Coogan, Andrew N.] Maynooth Univ, Natl Univ Ireland, Dept Psychol, Maynooth, Kildare, Ireland.
   [Healy, Ultan; Sreenan, Seamus; McDermott, John H.] Royal Coll Surgeons Ireland, Acad Dept Endocrinol, Connolly Hosp Blanchardstown, Dublin, Ireland.
   [Sreenan, Seamus; McDermott, John H.] 3U Diabet Consortium, Dublin, Ireland.
C3 Maynooth University; Royal College of Surgeons - Ireland
RP Coogan, AN (corresponding author), Maynooth Univ, Dept Psychol, Maynooth, Kildare, Ireland.
EM andrew.coogan@mu.ie
OI Coogan, Andrew/0000-0003-1998-0240; Sreenan, Seamus/0000-0003-2457-2612
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NR 48
TC 34
Z9 37
U1 2
U2 11
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1389-9457
EI 1878-5506
J9 SLEEP MED
JI Sleep Med.
PD FEB
PY 2020
VL 66
BP 1
EP 9
DI 10.1016/j.sleep.2019.07.023
PG 9
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA KN4UA
UT WOS:000514832800002
PM 31770613
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Chen, MH
   Su, TP
   Li, CT
   Chang, WH
   Chen, TJ
   Bai, YM
AF Chen, Mu-Hong
   Su, Tung-Ping
   Li, Cheng-Ta
   Chang, Wen-Han
   Chen, Tzeng-Ji
   Bai, Ya-Mei
TI Symptomatic Menopausal Transition Increases the Risk of New-Onset
   Depressive Disorder in Later Life: A Nationwide Prospective Cohort Study
   in Taiwan
SO PLOS ONE
LA English
DT Article
ID MIDLIFE WOMENS HEALTH; CHRONIC HEPATITIS-C; METABOLIC SYNDROME;
   CARDIOVASCULAR RISK; EARLY POSTMENOPAUSE; ASSOCIATION; HORMONES; MOOD;
   PREDICTORS; DISEASE
AB Introduction:The role of the menopausal transition and associated menopausal symptoms in the occurrence of depressive disorders has been discussed and debated for a long time. Most previous clinical studies had limited case samples, and did not control the attributable risk of medical comorbidities.
   Methods: Patients with a diagnosis of symptomatic menopausal transition and without a psychiatric history were enrolled in 2000 in Taiwan, and compared with age-matched controls (1:4). These subjects were followed to the end of 2010 to investigate the association between symptomatic menopausal transition and new-onset depressive disorder; the effect of medical comorbidities was also assessed.
   Results: A total of 5,837 women with symptomatic menopausal transition were identified, and compared with 23,348 age-matched controls in 2000. The follow-up showed that symptomatic menopausal transition was an independent risk factor for major depression (hazard ratio[HR]: 2.18, 95%CI: 1.79 similar to 2.65) and any depressive disorder (HR: 2.34, 95%CI: 2.08 similar to 2.63) after adjusting age at enrollment, monthly income, residence location, level of urbanization, and comorbid medical diseases. In addition, medical comorbidities, including cerebrovascular disease (HR: 1.77, 95% CI: 1.52 similar to 2.07), cardiovascular diseases (HR: 1.35, 95% CI: 1.15 similar to 1.57), congestive heart failure (HR: 1.35, 95% CI: 1.04 similar to 1.75), and liver diseases (HR: 1.19, 95% CI: 1.03 similar to 1.36) increased the risk of developing any depressive disorder.
   Conclusion:Our population cohort study, with the largest study sample and medical record diagnosis thus far, supports an association between symptomatic menopausal transition and depressive disorder in midlife women, and an increased risk of depressive disorder with medical comorbidities.
C1 [Chen, Mu-Hong; Su, Tung-Ping; Li, Cheng-Ta; Chang, Wen-Han; Bai, Ya-Mei] Taipei Vet Gen Hosp, Dept Psychiat, Taipei, Taiwan.
   [Su, Tung-Ping; Bai, Ya-Mei] Natl Yang Ming Univ, Coll Med, Dept Psychiat, Taipei 112, Taiwan.
   [Chen, Tzeng-Ji] Taipei Vet Gen Hosp, Dept Family Med, Taipei, Taiwan.
   [Li, Cheng-Ta] Natl Yang Ming Univ, Inst Brain Sci, Taipei 112, Taiwan.
   [Chen, Tzeng-Ji] Natl Yang Ming Univ, Inst Hosp & Hlth Care Adm, Taipei 112, Taiwan.
C3 Taipei Veterans General Hospital; National Yang Ming Chiao Tung
   University; Taipei Veterans General Hospital; National Yang Ming Chiao
   Tung University; National Yang Ming Chiao Tung University
RP Bai, YM (corresponding author), Taipei Vet Gen Hosp, Dept Psychiat, Taipei, Taiwan.
EM ymbi@mail2000.com.tw
RI Chen, MuHong/ACJ-6131-2022; Chen, TJ/AAH-8430-2021; Li,
   Cheng-Ta/AAI-5759-2021
OI Li, Cheng-Ta/0000-0002-0670-1153
FU Taipei Veterans General Hospital [V101D-001-1]
FX The study was supported by a grant from Taipei Veterans General Hospital
   (V101D-001-1). The funders had no role in study design, data collection
   and analysis, decision to publish, or preparation of the manuscript.
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NR 52
TC 20
Z9 22
U1 0
U2 7
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAR 27
PY 2013
VL 8
IS 3
AR e59899
DI 10.1371/journal.pone.0059899
PG 8
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Science & Technology - Other Topics
GA 124QO
UT WOS:000317480700068
PM 23544108
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Pan, P
   Qiu, Y
   Teng, ZW
   Li, SJ
   Huang, J
   Xiang, H
   Tang, H
   Chen, JD
   Wu, CJ
   Jin, K
   Wang, BL
   Liu, F
   Wu, HS
   Guo, WB
AF Pan, Pan
   Qiu, Yan
   Teng, Ziwei
   Li, Sujuan
   Huang, Jing
   Xiang, Hui
   Tang, Hui
   Chen, Jindong
   Wu, Chujun
   Jin, Kun
   Wang, Bolun
   Liu, Feng
   Wu, Haishan
   Guo, Wenbin
TI Increased Global-Brain Functional Connectivity Is Associated with
   Dyslipidemia and Cognitive Impairment in First-Episode, Drug-Naive
   Patients with Bipolar Disorder
SO NEURAL PLASTICITY
LA English
DT Article
ID SUPPORT VECTOR MACHINE; INFERIOR FRONTAL GYRUS; DEFAULT-MODE NETWORK;
   METABOLIC SYNDROME; MAJOR DEPRESSION; CINGULATE CORTEX; SUICIDE
   ATTEMPTS; SCHIZOPHRENIA; TRIGLYCERIDES; METAANALYSIS
AB Objectives. Previous researches have demonstrated that abnormal functional connectivity (FC) is associated with the pathophysiology of bipolar disorder (BD). However, inconsistent results were obtained due to different selections of regions of interest in previous researches. This study is aimed at examining voxel-wise brain-wide functional connectivity (FC) alterations in the first-episode, drug-naive patient with BD in an unbiased way. Methods. A total of 35 patients with BD and 37 age-, sex-, and education-matched healthy controls underwent resting-state functional magnetic resonance imaging (rs-fMRI). Global-brain FC (GFC) was applied to analyze the image data. Support vector machine (SVM) was adopted to probe whether GFC abnormalities could be used to identify the patients from the controls. Results. Patients with BD exhibited increased GFC in the left inferior frontal gyrus (LIFG), pars triangularis and left precuneus (PCu)/superior occipital gyrus (SOG). The left PCu belongs to the default mode network (DMN). Furthermore, increased GFC in the LIFG, pars triangularis was positively correlated with the triglycerides (TG) and low-density lipoprotein cholesterol (LDL-C) and negatively correlated with the scores of the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) coding test and Stroop color. Increased GFC values in the left PCu/SOG can be applied to discriminate patients from controls with preferable sensitivity (80.00%), specificity (75.68%), and accuracy (77.78%). Conclusions. This study found increased GFC in the brain regions of DMN; LIFG, pars triangularis; and LSOG, which was associated with dyslipidemia and cognitive impairment in patients with BD. Moreover, increased GFC values in the left PCu/SOG may be utilized as a potential biomarker to differentiate patients with BD from controls.
C1 [Pan, Pan; Qiu, Yan; Teng, Ziwei; Li, Sujuan; Huang, Jing; Xiang, Hui; Tang, Hui; Chen, Jindong; Wu, Chujun; Jin, Kun; Wu, Haishan; Guo, Wenbin] Cent South Univ, Xiangya Hosp 2, Natl Clin Res Ctr Mental Disorders, Changsha 410011, Hunan, Peoples R China.
   [Pan, Pan; Qiu, Yan; Teng, Ziwei; Li, Sujuan; Huang, Jing; Xiang, Hui; Tang, Hui; Chen, Jindong; Wu, Chujun; Jin, Kun; Wu, Haishan; Guo, Wenbin] Cent South Univ, Xiangya Hosp 2, Dept Psychiat, Changsha 410011, Hunan, Peoples R China.
   [Wang, Bolun] Cent South Univ, Dept Radiol, Xiangya Hosp 2, Changsha 410011, Hunan, Peoples R China.
   [Liu, Feng] Tianjin Med Univ, Dept Radiol, Gen Hosp, Tianjin 300000, Peoples R China.
   [Guo, Wenbin] Third Peoples Hosp Foshan, Dept Psychiat, Foshan 528000, Guangdong, Peoples R China.
C3 Central South University; Central South University; Central South
   University; Tianjin Medical University
RP Wu, HS; Guo, WB (corresponding author), Cent South Univ, Xiangya Hosp 2, Natl Clin Res Ctr Mental Disorders, Changsha 410011, Hunan, Peoples R China.; Wu, HS; Guo, WB (corresponding author), Cent South Univ, Xiangya Hosp 2, Dept Psychiat, Changsha 410011, Hunan, Peoples R China.; Guo, WB (corresponding author), Third Peoples Hosp Foshan, Dept Psychiat, Foshan 528000, Guangdong, Peoples R China.
EM 382670699@qq.com; yanqiu@csu.edu.cn; zaidc@csu.edu.cn;
   lisujuan@csu.edu.cn; jinghuangserena001@csu.edu.cn;
   452095746@csu.edu.cn; tanghui2017@csu.edu.cn; chenjindong@csu.edu.cn;
   wuchujun@csu.edu.cn; jk0811@csu.edu.cn; wangbolun@csu.edu.cn;
   feng_liu6@163.com; wuhaishan@csu.edu.cn; guowenbin76@csu.edu.cn
RI PAN, PAN/IWV-1122-2023; Liu, Feng/W-7572-2019; Wang,
   Bolun/AAD-3117-2022; Huang, Jing/NCV-0354-2025
OI Liu, Feng/0000-0002-3570-4222
FU National Key R&D Program of China [2016YFC1307100]; National Natural
   Science Foundation of China [81771447, 81971258, 81270019, 81501163];
   Natural Science Foundation of Hunan Province [2020JJ4784]; Key-Area
   Research and Development Program of Guangdong Province [2018B030334001];
   Commission Scientific Research Project of Hunan [C2019164]
FX The authors thank all individuals who served as the research
   participants. This study was supported by grants from the National Key
   R&D Program of China (2016YFC1307100), the National Natural Science
   Foundation of China (Grant Nos. 81771447, 81971258, 81270019, and
   81501163), the Natural Science Foundation of Hunan Province (Grant No.
   2020JJ4784), the Key-Area Research and Development Program of Guangdong
   Province (2018B030334001), and the Commission Scientific Research
   Project of Hunan (Grant No. C2019164).
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NR 87
TC 9
Z9 10
U1 2
U2 24
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2090-5904
EI 1687-5443
J9 NEURAL PLAST
JI Neural. Plast.
PD JUN 7
PY 2021
VL 2021
AR 5560453
DI 10.1155/2021/5560453
PG 10
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology
GA SY3UJ
UT WOS:000665816100001
PM 34194487
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Liao, HY
   Wang, CY
   Lee, CH
   Kao, HL
   Wu, WK
   Kuo, CH
AF Liao, Hsin-Yu
   Wang, Chin-Yi
   Lee, Ching-Hua
   Kao, Hsien-Li
   Wu, Wei-Kai
   Kuo, Ching-Hua
TI Development of an Efficient and Sensitive Chemical Derivatization-Based
   LC-MS/MS Method for Quantifying Gut Microbiota-Derived Metabolites in
   Human Plasma and Its Application in Studying Cardiovascular Disease
SO JOURNAL OF PROTEOME RESEARCH
LA English
DT Article
DE gut metabolites; SCFAs; bile acids; derivatization; LC-MS;
   cardiovascular disease
ID CHAIN FATTY-ACIDS; BILE-ACIDS; MASS-SPECTROMETRY; DIETARY FIBER;
   QUANTIFICATION; BLOOD; FECES
AB Recently, the gut microbiota has been found to be associated with many diseases, such as inflammatory bowel disease, depression, Parkinson's disease, cancer, metabolic syndrome, and cardiovascular disease (CVD). Among various gut microbiota-derived metabolites (GMs), short-chain fatty acids (SCFAs), bile acids (BAs), and tryptophan (TRP) metabolites are the most frequently discussed metabolites. LC-MS/MS shows advantages in quantifying the levels of metabolites with good sensitivity and selectivity; however, the poor ionization efficiency and polar characteristics of SCFAs make their analysis challenging, especially when analyzing plasma samples with low SCFA concentrations. Moreover, without characteristic fragment ions for unconjugated BAs and different detection ion modes for TRP metabolites and BAs, GM analysis is complex and time-consuming. To overcome these problems, we developed a derivatization method combined with LC-MS/MS to enhance the sensitivity and LC retention of GMs. Through derivatization with 3-nitrophenylhydrazine (3-NPH), 7 SCFAs, 9 bile acids, and 6 tryptophan metabolites can be simultaneously analyzed via separation within 14 min on a reversed-phase C18 column. For accurate quantification, C-13(6)-3NPH-labeled standards were used as one-to-one internal standards. This derivatization approach was optimized and then validated. We further applied this method to investigate the targeted GM profile in patients with CVD. The results showed a significant reduction in plasma butyrate levels in CVD patients compared with healthy controls, suggesting its potentially protective role in CVD. In summary, this work provides a sensitive and effective LC-MS/MS method for simultaneously quantifying gut microbiota-related metabolites in human plasma, which could benefit various future gut microbiota-related studies.
C1 [Liao, Hsin-Yu; Wang, Chin-Yi; Lee, Ching-Hua; Kuo, Ching-Hua] Natl Taiwan Univ, Coll Med, Sch Pharm, Taipei 10051, Taiwan.
   [Liao, Hsin-Yu; Wang, Chin-Yi; Lee, Ching-Hua; Kuo, Ching-Hua] Natl Taiwan Univ Hosp, Dept Pharm, Taipei 10051, Taiwan.
   [Kao, Hsien-Li] Natl Taiwan Univ Hosp, Dept Internal Med, Div Cardiol, Taipei 10048, Taiwan.
   [Kao, Hsien-Li] Natl Taiwan Univ Hosp, Cardiovasc Ctr, Taipei 10048, Taiwan.
   [Wu, Wei-Kai] Natl Taiwan Univ Hosp, Dept Med Res, Taipei 10048, Taiwan.
   [Kuo, Ching-Hua] Natl Taiwan Univ, Ctr Genom, Metabol Core Lab, Taipei 10055, Taiwan.
   [Kuo, Ching-Hua] Natl Taiwan Univ, Ctr Precis Med, Metabol Core Lab, Taipei 10055, Taiwan.
C3 National Taiwan University; National Taiwan University; National Taiwan
   University Hospital; National Taiwan University; National Taiwan
   University Hospital; National Taiwan University; National Taiwan
   University Hospital; National Taiwan University; National Taiwan
   University Hospital; National Taiwan University; National Taiwan
   University
RP Kuo, CH (corresponding author), Natl Taiwan Univ, Coll Med, Sch Pharm, Taipei 10051, Taiwan.; Kuo, CH (corresponding author), Natl Taiwan Univ Hosp, Dept Pharm, Taipei 10051, Taiwan.; Wu, WK (corresponding author), Natl Taiwan Univ Hosp, Dept Med Res, Taipei 10048, Taiwan.; Kuo, CH (corresponding author), Natl Taiwan Univ, Ctr Genom, Metabol Core Lab, Taipei 10055, Taiwan.; Kuo, CH (corresponding author), Natl Taiwan Univ, Ctr Precis Med, Metabol Core Lab, Taipei 10055, Taiwan.
EM weikaiwu0115@gmail.com; kuoch@ntu.edu.tw
RI Wu, Wei-Kai/AAK-9631-2021
OI KAO, HSIEN-LI/0000-0002-5278-3540; Wang, Chin-Yi/0009-0006-5041-2734
FU Ministry of Science and Technology, Taiwan [MOST 107-2113-M-002 -016
   -MY3, 1082314-B-002-032-and 109-2314-B-002 -064 -MY3]
FX This study was supported by the Ministry of Science and Technology,
   Taiwan (MOST 107-2113-M-002 -016 -MY3, 1082314-B-002-032-and
   109-2314-B-002 -064 -MY3).
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NR 49
TC 24
Z9 24
U1 8
U2 94
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1535-3893
EI 1535-3907
J9 J PROTEOME RES
JI J. Proteome Res.
PD JUL 2
PY 2021
VL 20
IS 7
BP 3508
EP 3518
DI 10.1021/acs.jproteome.1c00147
EA MAY 2021
PG 11
WC Biochemical Research Methods
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA TF4CD
UT WOS:000670662100011
PM 34053222
DA 2025-06-11
ER

PT J
AU Ferreira, SC
   Penaforte, FRD
   Cardoso, A
   da Silva, MVT
   Lima, AS
   Correia, MITD
   Anastacio, LR
AF Ferreira, Samanta Catherine
   de Oliveira Penaforte, Fernanda Rodrigues
   Cardoso, Amanda
   Teixeira da Silva, Marcelo Victor
   Lima, Agnaldo Silva
   Davisson Correia, Maria Isabel Toulson
   Anastacio, Lucilene Rezende
TI Association of food cravings with weight gain, overweight, and obesity
   in patients after liver transplantation
SO NUTRITION
LA English
DT Article
DE Excessive weight; Food craving; Liver transplantation; Obesity; Weight
   gain
ID QUALITY-OF-LIFE; BODY-COMPOSITION; METABOLIC SYNDROME; DIETARY-INTAKE;
   VALIDATION; TRAIT; STATE; QUESTIONNAIRES; DEPRESSION; ADDICTION
AB Objective: After liver transplantation (LTx), patients often gain weight and many become overweight or obese; however, the association between LTx and food craving (FC) is unknown. The aim of this study was to describe FC among patients after LTx and verify its association with weight gain and obesity.
   Methods: This was a cross-sectional study that assessed 301 patients who underwent LTx (55.1 +/- 12.7 y of age; time since LTx 6.6 +/- 4.4 y; 64.1% men). Pregnant or nursing women were exduded. Patients were interviewed once either in the outpatient clinic or by completing the online questionnaire, from August 2016 to February 2017.
   Results: The median weight variation after Ltx was 8 kg (ranging from -16 to +41 kg). At evaluation, 62.5% (n = 188) of the patients presented excessive weight and 22.3% (n = 67) presented with obesity. The average score on the Food Craving Questionnaire-State (FCQ-S) was 33.4 +/- 9 and for the Food Craving Questionnaire Trait (FCQ-T) the median score was 68 (39-163). The FCQ-T dimensions of lack of control, preoccupation, emotion, environmental triggers/stimuli, and guilt correlated positively with weight gain (P < 0.05). The desire dimension on the FCQ-S was significantly associated with overweight in post-LTx patients (P < 0.05) and the FCQ-T dimensions [negative reinforcement (P = 0.013), lack of control (P = 0.016), emotion (P = 0.009), environmental triggers stimuli (P = 0.029), and guilt (P = 0.007)] were associated with obesity.
   Conclusion: Lack of control, preoccupation, emotion, trigger, and guilt were positively correlated with weight gain. Desire was significantly associated with overweight. Negative reinforcement, lack of control, emotion, environmental triggers/stimuli, and guilt were associated with obesity. (C) 2019 Elsevier Inc. All rights reserved.
C1 [Ferreira, Samanta Catherine; Teixeira da Silva, Marcelo Victor; Anastacio, Lucilene Rezende] Univ Fed Minas Gerais, Food Sci Post Grad Program, Belo Horizonte, MG, Brazil.
   [de Oliveira Penaforte, Fernanda Rodrigues] Univ Fed Triangulo Mineiro, Nutr Dept, Uberaba, MG, Brazil.
   [Cardoso, Amanda] Univ Fed Minas Gerais, Nutr Course, Belo Horizonte, MG, Brazil.
   [Lima, Agnaldo Silva; Davisson Correia, Maria Isabel Toulson] Univ Fed Minas Gerais, Surg Dept, Belo Horizonte, MG, Brazil.
   [Anastacio, Lucilene Rezende] Univ Fed Minas Gerais, Food Sci Dept, Belo Horizonte, MG, Brazil.
C3 Universidade Federal de Minas Gerais; Universidade Federal do Triangulo
   Mineiro; Universidade Federal de Minas Gerais; Universidade Federal de
   Minas Gerais; Universidade Federal de Minas Gerais
RP Anastacio, LR (corresponding author), Univ Fed Minas Gerais, Food Sci Post Grad Program, Belo Horizonte, MG, Brazil.; Anastacio, LR (corresponding author), Univ Fed Minas Gerais, Food Sci Dept, Belo Horizonte, MG, Brazil.
EM lucilene.rezende@gmail.com
RI Correia, Maria/I-8617-2012; Ferreira, Samanta/IXD-3783-2023; Lima,
   Agnaldo/F-7452-2011; Cardoso, Amanda/KPB-5350-2024
OI Toulson Davisson Correia, Maria Isabel/0000-0002-3503-4302; Lima,
   Agnaldo Soares/0000-0001-6421-3062; Ferreira, Samanta
   Catherine/0000-0002-6240-8488; Teixeira da Silva, Marcelo
   Victor/0000-0002-3106-4360; Rezende Anastacio,
   Lucilene/0000-0002-2269-0722
FU Coordination for the Improvement of Higher Education Personnel-Capes;
   National Council for Scientific and Technological Development-CNPq
   [301593/2016-7]; Minas Gerais Research Foundation-FAPEMIG [APQ-01582-14]
FX This study was funded by Funding Agencies in Brazil: Coordination for
   the Improvement of Higher Education Personnel-Capes. (Scholarship to
   SCF); National Council for Scientific and Technological Development-CNPq
   (grant no. 301593/2016-7 scholarship to MITDC); and Minas Gerais
   Research Foundation-FAPEMIG (grant no, APQ-01582-14 scholarship to
   MITDC). The authors have no conflicts of interest to declare.
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NR 51
TC 4
Z9 4
U1 0
U2 9
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0899-9007
EI 1873-1244
J9 NUTRITION
JI Nutrition
PD JAN
PY 2020
VL 69
AR 110573
DI 10.1016/j.nut.2019.110573
PG 5
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nutrition & Dietetics
GA JW2JL
UT WOS:000502883900016
PM 31585257
DA 2025-06-11
ER

PT J
AU Mohamed, MAS
   AbouKhatwa, MM
   Saifullah, AA
   Syahmi, MH
   Mosaad, M
   Elrggal, ME
   Dehele, IS
   Elnaem, MH
AF Mohamed, Mossad Abdelhak Shaban
   AbouKhatwa, Merna Mahmoud
   Saifullah, Abdul Aziz
   Syahmi, Muhammad Hareez
   Mosaad, Mohamed
   Elrggal, Mahmoud E.
   Dehele, Inderpal Singh
   Elnaem, Mohamed Hassan
TI Risk Factors, Clinical Consequences, Prevention, and Treatment of
   Childhood Obesity
SO CHILDREN-BASEL
LA English
DT Review
DE risk factors; prevention; treatment; childhood; obesity
ID BODY-MASS INDEX; METABOLIC SYNDROME; BARIATRIC SURGERY;
   PHYSICAL-ACTIVITY; SLEEP DURATION; IMPACT; OVERWEIGHT; CHILDREN;
   ADOLESCENTS; WEIGHT
AB Obesity might adversely affect the health and well-being of children and their families. Childhood obesity has crucial implications for health, both during childhood and as they age. It is highly associated with many acute problems and is commonly present during childhood, making visits and hospital admissions polarized in this group of children. The problems that may affect these children can be medical, such as asthma, chronic inflammation, orthopedic abnormalities, liver disease, diabetes mellitus or dyslipidemia. Long-term consequences of cardiovascular risk factors, the persistence of obesity and premature mortality are common among adults who had obesity during their early lives. Additionally, they could also suffer from psychological issues, such as low self-esteem, which puts them at risk of a much more serious psychosocial problem that may lead to depression, as well as a disruption in educational achievements and social relationships. A healthy diet, physical activity, adequate sleep, and limited screen time are all preventive measures that should be implemented at the family and community levels, preferably through well-structured programs. Furthermore, pharmacological management of childhood obesity is limited and only used after non-pharmacological interventions have failed or in the late stages of obesity. However, recent guidelines advocate the early use of medical interventions. Approved pharmacotherapeutic options include orlistat, phentermine/topiramate combination and liraglutide. There are several other options approved primarily for other specific forms of obesity or for other indications, including setmelanotide, metformin, lisdexamfetamine, zonisamide and fluoxetine. Bariatric surgery is a safe and effective option in cases with extreme obesity and comorbidities considering the need for long-term monitoring and support for cases and their families post-surgery. This review aims to discuss and highlight the recent evidence regarding risk factors, clinical consequences, prevention, and treatment of childhood obesity.
C1 [Mohamed, Mossad Abdelhak Shaban] Int Islamic Univ Malaysia, Fac Med, Dept Pediat, Kuantan 25200, Malaysia.
   [AbouKhatwa, Merna Mahmoud] Alexandria Univ, Fac Pharm, Dept Clin Pharm & Pharm Practice, Alexandria, Egypt.
   [Saifullah, Abdul Aziz; Syahmi, Muhammad Hareez] Int Islamic Univ Malaysia, Fac Med, Kuantan 25200, Malaysia.
   [Mosaad, Mohamed] Widad Univ Coll, Fac Med, Kuantan 25200, Malaysia.
   [Elrggal, Mahmoud E.] Umm Al Qura Univ, Coll Pharm, Mecca 21955, Saudi Arabia.
   [Dehele, Inderpal Singh] Univ Birmingham, Sch Pharm, Birmingham B15 2TT, England.
   [Elnaem, Mohamed Hassan] Univ Sains Malaysia, Sch Pharmaceut Sci, George Town 11800, Malaysia.
C3 International Islamic University Malaysia; Egyptian Knowledge Bank
   (EKB); Alexandria University; International Islamic University Malaysia;
   Umm Al-Qura University; University of Birmingham; Universiti Sains
   Malaysia
RP Elnaem, MH (corresponding author), Univ Sains Malaysia, Sch Pharmaceut Sci, George Town 11800, Malaysia.
EM drmelnaem@gmail.com
RI Elrggal, Mahmoud/C-1417-2014; Elnaem, Mohamed Hassan/O-9248-2017
OI Elrggal, Mahmoud/0000-0002-0026-5514; Elnaem, Mohamed
   Hassan/0000-0003-0873-6541; AbouKhatwa, Merna/0000-0003-2610-7183
FU Deanship of Scientific Research at Umm Al-Qura University; 
   [22UQU4320605DSR07]
FX This research received no external funding.
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NR 114
TC 18
Z9 19
U1 5
U2 39
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2227-9067
J9 CHILDREN-BASEL
JI Children-Basel
PD DEC
PY 2022
VL 9
IS 12
AR 1975
DI 10.3390/children9121975
PG 16
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA 7D5TH
UT WOS:000900552100001
PM 36553418
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Dieli-Conwright, CM
   Courneya, KS
   Demark-Wahnefried, W
   Sami, N
   Lee, K
   Sweeney, FC
   Stewart, C
   Buchanan, TA
   Spicer, D
   Tripathy, D
   Bernstein, L
   Mortimer, JE
AF Dieli-Conwright, Christina M.
   Courneya, Kerry S.
   Demark-Wahnefried, Wendy
   Sami, Nathalie
   Lee, Kyuwan
   Sweeney, Frank C.
   Stewart, Christina
   Buchanan, Thomas A.
   Spicer, Darcy
   Tripathy, Debu
   Bernstein, Leslie
   Mortimer, Joanne E.
TI Aerobic and resistance exercise improves physical fitness, bone health,
   and quality of life in overweight and obese breast cancer survivors: a
   randomized controlled trial
SO BREAST CANCER RESEARCH
LA English
DT Article
DE Exercise; quality of life; physical fitness; bone health; breast cancer
ID BODY-COMPOSITION; FATIGUE; INTERVENTION; ADHERENCE; STRENGTH; PROGRAM;
   INSULIN
AB BackgroundExercise is an effective strategy to improve quality of life and physical fitness in breast cancer survivors; however, few studies have focused on the early survivorship period, minorities, physically inactive and obese women, or tested a combined exercise program and measured bone health. Here, we report the effects of a 16-week aerobic and resistance exercise intervention on patient-reported outcomes, physical fitness, and bone health in ethnically diverse, physically inactive, overweight or obese breast cancer survivors.MethodsOne hundred breast cancer survivors within 6months of completing adjuvant treatment were assessed at baseline, post-intervention, and 3-month follow-up (exercise group only) for physical fitness, bone mineral density, serum concentrations of bone biomarkers, and quality of life. The exercise intervention consisted of moderate-vigorous (65-85% heart rate maximum) aerobic and resistance exercise thrice weekly for 16weeks. Differences in mean changes for outcomes were evaluated using mixed-model repeated measure analysis.ResultsAt post-intervention, the exercise group was superior to usual care for quality of life (between group difference: 14.7, 95% CI: 18.2, 9.7; p<0.001), fatigue (p<0.001), depression (p<0.001), estimated VO2max (p<0.001), muscular strength (p<0.001), osteocalcin (p=0.01), and BSAP (p=0.001). At 3-month follow-up, all patient-reported outcomes and physical fitness variables remained significantly improved compared to baseline in the exercise group (p<0.01).ConclusionsA 16-week combined aerobic and resistance exercise program designed to address metabolic syndrome in ethnically-diverse overweight or obese breast cancer survivors also significantly improved quality of life and physical fitness. Our findings further support the inclusion of supervised clinical exercise programs into breast cancer treatment and care.Trial registrationThis trial is registered on ClinicalTrials.gov: NCT01140282 as of June 9, 2010.
C1 [Dieli-Conwright, Christina M.; Sami, Nathalie; Lee, Kyuwan; Sweeney, Frank C.; Stewart, Christina] USC, Div Biokinesiol & Phys Therapy, 1540 E Alcazar St,CHP 155, Los Angeles, CA 90089 USA.
   [Courneya, Kerry S.] Univ Alberta, Fac Kinesiol Sport & Recreat, Edmonton, AB T6G 2H9, Canada.
   [Demark-Wahnefried, Wendy] Univ Alabama Birmingham, Dept Nutr Sci, Birmingham, AL 35294 USA.
   [Buchanan, Thomas A.] USC, Keck Sch Med, Div Endocrinol & Diabet, Los Angeles, CA 90033 USA.
   [Dieli-Conwright, Christina M.; Spicer, Darcy] Univ Southern Calif, Keck Sch Med, Dept Med, Los Angeles, CA 90033 USA.
   [Tripathy, Debu] Univ Texas MD Anderson Canc Ctr, Dept Breast Med Oncol, Houston, TX 77030 USA.
   [Bernstein, Leslie] COH, Beckman Res Inst, Div Biomarkers Early Detect & Prevent, Duarte, CA 91010 USA.
   [Mortimer, Joanne E.] COH, Div Med Oncol & Expt Therapeut, Duarte, CA 91010 USA.
C3 University of Southern California; University of Alberta; University of
   Alabama System; University of Alabama Birmingham; University of Southern
   California; University of Southern California Keck Hospital; University
   of Southern California; University of Texas System; UTMD Anderson Cancer
   Center; City of Hope; Beckman Research Institute of City of Hope
RP Dieli-Conwright, CM (corresponding author), USC, Div Biokinesiol & Phys Therapy, 1540 E Alcazar St,CHP 155, Los Angeles, CA 90089 USA.; Dieli-Conwright, CM (corresponding author), Univ Southern Calif, Keck Sch Med, Dept Med, Los Angeles, CA 90033 USA.
EM cdieli@usc.edu
RI Lee, Kyuwan/E-2593-2018; Courneya, Kerry/AAJ-2712-2021; Tripathy,
   Debu/AAW-4968-2020
OI Dieli-Conwright, Christina/0000-0001-9093-7259; Demark-Wahnefried,
   Wendy/0000-0001-5241-932X
FU National Cancer Institute [K07CA160718]; National Center for Advancing
   Translational Science (NCATS) of the U.S. National Institutes of Health
   [UL1TR001855, UL1TR000130]
FX This work was supported by grants K07CA160718 from the National Cancer
   Institute, UL1TR001855 and UL1TR000130 from the National Center for
   Advancing Translational Science (NCATS) of the U.S. National Institutes
   of Health.
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NR 32
TC 198
Z9 217
U1 3
U2 47
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1465-542X
EI 1465-5411
J9 BREAST CANCER RES
JI Breast Cancer Res.
PD OCT 19
PY 2018
VL 20
AR 124
DI 10.1186/s13058-018-1051-6
PG 10
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA GX6KB
UT WOS:000447868800002
PM 30340503
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Squassina, A
   Niola, P
   Lopez, JP
   Cruceanu, C
   Pisanu, C
   Congiu, D
   Severino, G
   Ardau, R
   Chillotti, C
   Alda, M
   Turecki, G
   Del Zompo, M
AF Squassina, Alessio
   Niola, Paola
   Lopez, Juan Pablo
   Cruceanu, Cristiana
   Pisanu, Claudia
   Congiu, Donatella
   Severino, Giovanni
   Ardau, Raffaella
   Chillotti, Caterina
   Alda, Martin
   Turecki, Gustavo
   Del Zompo, Maria
TI MicroRNA expression profiling of lymphoblasts from bipolar disorder
   patients who died by suicide, pathway analysis and integration with
   postmortem brain findings
SO EUROPEAN NEUROPSYCHOPHARMACOLOGY
LA English
DT Article
DE Suicide; Bipolar disorder; Lithium; MicroRNA; Postmortem brains; Cell
   cultures
ID INSULIN-RESISTANCE; GENE-EXPRESSION; MOOD DISORDERS; METABOLIC SYNDROME;
   PREFRONTAL CORTEX; MAJOR DEPRESSION; RISK; MIRNAS; BEHAVIOR; LITHIUM
AB Post-mortem brain studies suggest that miRNAs may be involved in suicide, but their role as peripheral biomarkers or targets of preventive pharmacological treatments in suicide has yet to be elucidated. We used nCounter miRNA Expression assay to measure miRNAs expression in lymphoblastoid cell lines (LCLs) from patients with Bipolar Disorder (BD) who died by suicide (SC, n = 7) and with low risk of suicide (LR, n = 11). Five miRNAs were differentially expressed in SC compared to LR (false discovery rate p <0.05). The two most significant miRNAs were measured with RT-qPCR in the same sample and in 12 healthy controls (HC): miR-4286 was increased while miR-186-5p was decreased in SC compared to LR and HC (ANOVA F = 14.92, p = 0.000043 and F = 3.95, p = 0.032 respectively). miR-4286 was also decreased in postmortem brains from 12 patients with BD who died by suicide compared to 13 controls, even though it did not reach statistical significance (FC=0.51, p = 0.07). Treatment with lithium of human neural progenitor cells reduced the expression of miR-4286 (FC=0.30, p = 0.038). Pathway analysis on predicted miR-4286 targets showed that "insulin resistance" was significantly enriched after correction for multiple testing. This pathway comprised 17 genes involved in lipid and glucose metabolism, several of which were also dysregulated in postmortem brains from patients with BD who died by suicide from the Stanley-foundation array collection. In conclusion, our study suggests that miR-4286 could be a biomarker of suicide but further studies are warranted to investigate its targeted genes and how these could be involved in the neurobiology of suicide. (C) 2020 Elsevier B.V. and ECNP. All rights reserved.
C1 [Squassina, Alessio; Niola, Paola; Pisanu, Claudia; Congiu, Donatella; Severino, Giovanni; Del Zompo, Maria] Univ Cagliari, Dept Biomed Sci, Sect Neurosci & Clin Pharmacol, Cagliari, Italy.
   [Niola, Paola] UCL Great Ormond St Inst Child Hlth, UCL Genom, London, England.
   [Lopez, Juan Pablo; Cruceanu, Cristiana; Turecki, Gustavo] McGill Univ, Douglas Mental Hlth Univ Inst, Dept Psychiat, McGill Grp Suicide Studies, Montreal, PQ, Canada.
   [Ardau, Raffaella; Chillotti, Caterina; Del Zompo, Maria] Univ Hosp Cagliari, Unit Clin Pharmacol, Cagliari, Italy.
   [Alda, Martin] Dalhousie Univ, Dept Psychiat, Halifax, NS, Canada.
C3 University of Cagliari; University of London; University College London;
   McGill University; University of Cagliari; Azienda
   Ospedaliero-Universitaria di Cagliari; Dalhousie University
RP Squassina, A (corresponding author), Univ Cagliari, Dept Biomed Sci, Sect Neurosci & Clin Pharmacol, Cagliari, Italy.
EM squassina@unica.it
RI Cruceanu, Cristiana/AAK-2885-2021; Pisanu, Claudia/AAA-3699-2019; Lopez,
   Juan Pablo/AAM-5727-2021; Turecki, Gustavo/K-5100-2015; Alda,
   Martin/F-5812-2010
OI Cruceanu, Cristiana/0000-0002-7799-5531; Alda,
   Martin/0000-0001-9544-3944; Niola, Paola/0000-0002-3377-5991; Pisanu,
   Claudia/0000-0002-9151-4319; Lopez, Juan Pablo/0000-0002-5812-4220
FU Fondazione Banco di Sardegna annualita2014 [U1035.2014/AI.917.MGB];
   Fondo Integrativo per la Ricerca (FIR), 2018; Fondazione Umberto
   Veronesi Fellowship 2019; Sardinia Regional Government (POR Sardegna FSE
   Operational Program of the Autonomous Region of Sardinia, European
   Social Fund 2007-2013-Axis IV Human Resources, Objective l.3, Line of
   Activity l.3.1
FX This work was partly funded with a grant by Fondazione Banco di Sardegna
   annualita2014 (prot. U1035.2014/AI.917.MGB) and by Fondo Integrativo per
   la Ricerca (FIR), 2018. CP is supported by a Fondazione Umberto Veronesi
   Fellowship 2019. At time of work preparation, AS was a post-doctoral
   research fellow funded with a project from the Sardinia Regional
   Government (POR Sardegna FSE Operational Program of the Autonomous
   Region of Sardinia, European Social Fund 2007-2013-Axis IV Human
   Resources, Objective l.3, Line of Activity l.3.1.
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NR 63
TC 16
Z9 18
U1 3
U2 9
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29a, 1043 NX AMSTERDAM, NETHERLANDS
SN 0924-977X
EI 1873-7862
J9 EUR NEUROPSYCHOPHARM
JI Eur. Neuropsychopharmacol.
PD MAY
PY 2020
VL 34
BP 39
EP 49
DI 10.1016/j.euroneuro.2020.03.005
PG 11
WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA LV4DD
UT WOS:000538387100004
PM 32241689
DA 2025-06-11
ER

PT J
AU Hardeland, R
AF Hardeland, Ruediger
TI Melatonin and Synthetic Melatoninergic Agonists in Psychiatric and
   Age-associated Disorders: Successful and Unsuccessful Approaches
SO CURRENT PHARMACEUTICAL DESIGN
LA English
DT Article
DE Agomelatine; Alzheimer's disease; melatonin; Parkinson's disease;
   ramelteon; sleep; tasimelteon; TIK-301
ID HUMAN CIRCADIAN-RHYTHMS; CENTRAL-NERVOUS-SYSTEM; DELAYED SLEEP PHASE;
   RECEPTOR EXPRESSION; METABOLIC SYNDROME; SUPRACHIASMATIC NUCLEUS;
   PRIMARY INSOMNIA; LENGTH POLYMORPHISM; ALZHEIMERS-DISEASE;
   INSULIN-RESISTANCE
AB Melatonin and the following approved or investigational synthetic melatoninergic agonists are compared with regard to half-life, receptor affinity, metabolism and additional properties: TIK-301, piromelatine, GG-012, AH-001, AH-017, agomelatine, ramelteon, GR 196429, MA-2, tasimelteon, UCM765, and UCM924. Apart from restrictions from the respective approvals, theoretical limits of treatment are outlined as they result from chronobiological, genetic, epigenetic, degenerative or toxicological considerations. Melatoninergic agonists have been shown to reliably entrain circadian rhythms, if chronobiological phase response rules are followed. This allows the treatment of dysphased rhythms, circadian rhythm sleep disorders, and forms of depression with an etiology of circadian dysfunction, such as bipolar disorder and seasonal affective disorders. Entrainment and induction of sleep onset requires only short actions, with low doses of immediate-release melatonin likely to be sufficient. However, sleep maintenance is poorly supported by any of the agonists, despite statistically demonstrable effects. The combinations of melatoninergic properties with the inhibition of 5-HT2C receptors, as in agomelatine and TIK-30, may result in moderate direct antidepressive actions. Other limits of a successful treatment can arise from genetic or epigenetic silencing of melatonin receptor genes, perhaps also from imbalances between parallel signaling pathways in receptor mutants, and from neurodegeneration, especially in the suprachiasmatic nucleus. Variants of circadian clock genes cause rhythm deviations that may be corrected by melatoninergic treatment, provided that the spontaneous oscillation period is not beyond the entrainment range. Caveats concerning melatonin's roles as an immune modulator and in certain pathologies, such as Parkinson's disease, as well as toxicological considerations for agonists and their metabolites are also addressed.
C1 [Hardeland, Ruediger] Univ Gottingen, Johann Friedrich Blumenbach Inst Zool & Anthropol, Berliner Str 28, D-37073 Gottingen, Germany.
C3 University of Gottingen
RP Hardeland, R (corresponding author), Univ Gottingen, Johann Friedrich Blumenbach Inst Zool & Anthropol, Berliner Str 28, D-37073 Gottingen, Germany.
EM rhardel@gwdg.de
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NR 174
TC 22
Z9 23
U1 0
U2 27
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1381-6128
EI 1873-4286
J9 CURR PHARM DESIGN
JI Curr. Pharm. Design
PY 2016
VL 22
IS 8
BP 1086
EP 1101
DI 10.2174/1381612822666151214125543
PG 16
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA DG4VT
UT WOS:000372071900013
PM 25248806
DA 2025-06-11
ER

PT J
AU Zhang, WY
   Liang, J
   Li, CL
   Pan, Y
   Gao, DR
   Wang, YQ
   Xie, WX
   Zheng, FF
AF Zhang, Wenya
   Liang, Jie
   Li, Chenglong
   Pan, Yang
   Gao, Darui
   Wang, Yongqian
   Xie, Wuxiang
   Zheng, Fanfan
TI Association of Cumulative Blood Pressure With Progression of Depressive
   Symptoms and Functional Impairment Among Adults Aged 50 Years or Older:
   10-Year Follow-up of 2 Longitudinal Cohorts
SO JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL
   SCIENCES
LA English
DT Article
DE Cumulative blood pressure; Depressive symptoms; Functional impairment;
   Longitudinal cohort study
ID METABOLIC SYNDROME; COGNITIVE DECLINE; HYPERTENSION; DISABILITY;
   DISEASE; VARIABILITY; MECHANISMS; DEMENTIA; PROFILE; HEALTH
AB Background: The association of cumulative blood pressure (BP) with progression rate of depressive symptoms and functional impairment remained largely unknown, and this study aims to explore whether higher cumulative BP is associated with a faster rate of aggravation of depressive symptoms and functional impairment. Methods: This longitudinal cohort study adopted data from the English Longitudinal Study of Ageing (ELSA) and the Health and Retirement Study (HRS). Cumulative BP was calculated as area under the curve using BP measurements from 3 visits (wave 0, 2, and 4) in ELSA and 2 visits (wave 8 and 10) in HRS. Depressive symptoms were evaluated in a biennial frequency via Center for Epidemiological Studies Depression (CES-D) scale, while functional status was measured every 2 years using adapted versions of Katz Activities of Daily Living (ADL) scale and Lawton Instrumental Activities of Daily Living (IADL) scale. Results: A total of 3 500 and 6 036 participants from ELSA and HRS were included. Elevated cumulative pulse pressure was significantly associated with accelerated aggravation of depressive symptoms (p < .001 for both). Elevated cumulative systolic BP and pulse pressure were significantly associated with accelerated decline of ADL function (p < .001 for both) and IADL function (p < .001 for both). However, elevated cumulative diastolic BP was associated with decelerated decline of IADL function (p = .031 in ELSA and p < .001 in HRS). Conclusions: Elevated cumulative BP was associated with accelerated aggravation of depressive symptoms and functional impairment, suggesting that controlling systolic BP and pulse pressure while maintaining adequate diastolic BP is of paramount importance for adults to achieve health longevity.
C1 [Zhang, Wenya; Liang, Jie; Pan, Yang; Zheng, Fanfan] Chinese Acad Med Sci & Peking Union Med Coll, Sch Nursing, Beijing, Peoples R China.
   [Li, Chenglong] Peking Univ, Natl Inst Hlth Data Sci, Beijing, Peoples R China.
   [Gao, Darui; Xie, Wuxiang] Peking Univ First Hosp, Dept Endocrinol, Beijing, Peoples R China.
   [Gao, Darui; Wang, Yongqian; Xie, Wuxiang] Peking Univ, Clin Res Inst, Inst Adv Clin Med, Beijing, Peoples R China.
   [Wang, Yongqian] Peking Univ, Beijing Huilongguan Hosp, Huilongguan Clin Med Sch, Med Sci Sect, Beijing, Peoples R China.
C3 Chinese Academy of Medical Sciences - Peking Union Medical College;
   Peking Union Medical College; Peking University; Peking University;
   Peking University
RP Zheng, FF (corresponding author), Chinese Acad Med Sci & Peking Union Med Coll, Sch Nursing, Beijing, Peoples R China.; Xie, WX (corresponding author), Peking Univ First Hosp, Dept Endocrinol, Beijing, Peoples R China.; Xie, WX (corresponding author), Peking Univ, Clin Res Inst, Inst Adv Clin Med, Beijing, Peoples R China.
EM xiewuxiang@hsc.pku.edu.cn; zhengfanfan@nursing.pumc.edu.cn
FU National Natural Science Foundation of China [82373665, 81974490];
   Non-profit Central Research Institute Fund of Chinese Academy of Medical
   Sciences [2021-RC330-001]; China Medical Board-Open Competition research
   [22-466]
FX This study was supported by the National Natural Science Foundation of
   China (82373665 and 81974490), the Non-profit Central Research Institute
   Fund of Chinese Academy of Medical Sciences (2021-RC330-001), and the
   2022 China Medical Board-Open Competition research grant (22-466).
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NR 54
TC 0
Z9 0
U1 1
U2 1
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1079-5006
EI 1758-535X
J9 J GERONTOL A-BIOL
JI J. Gerontol. Ser. A-Biol. Sci. Med. Sci.
PD JUN
PY 2025
VL 80
IS 6
AR glaf080
DI 10.1093/gerona/glaf080
PG 9
WC Geriatrics & Gerontology; Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA 3HD1R
UT WOS:001500216800001
PM 40244688
DA 2025-06-11
ER

PT J
AU 't Veld, DHI
   Pengpid, S
   Colebunders, R
   Peltzer, K
AF ' t Veld, Diana Huis In
   Pengpid, Supa
   Colebunders, Robert
   Peltzer, Karl
TI Body Mass Index and Waist Circumference in Patients with HIV in South
   Africa and Associated Socio-demographic, Health Related and Psychosocial
   Factors
SO AIDS AND BEHAVIOR
LA English
DT Article
DE HIV; BMI; South Africa; Psychosocial socio-demographic health related
   factors
ID ANTIRETROVIRAL THERAPY; METABOLIC SYNDROME; INFECTED PATIENTS; OBESITY;
   RISK; URBAN; RACE; AIDS
AB A high body mass index (BMI) and high waist circumference are important health risk factors predisposing for cardiovascular and metabolic diseases and certain cancers. Historically, underweight was a diagnostic criterion of HIV-infection. In a cross-sectional study the prevalence of BMI-categories and high waist circumference and its associated factors in patients visiting three outpatient HIV clinics in South Africa were measured with anthropometric measurements and structured questionnaires regarding socio-demographic information, quality of life (QoL), AIDS-related stigma, symptoms of depression, alcohol use, HIV related information and level of adherence to ART. The median age of the 2230 included patients was 37 years, 66.5% were women and 88.6% received antiretroviral therapy. The prevalences of overweight, obesity and high waist circumference were 29.2, 21.9 and 44.6% respectively in women and 12.4, 4.0 and 3.9% respectively in men. Underweight was found in 18.2% of men and 6.3% of women. In multinomial regression analysis compared to a normal BMI, both overweight and obesity were associated with female gender, with being married or cohabiting and with a higher QoL score. Underweight was associated with male gender and tobacco use and negatively associated with being married or cohabiting and the physical domain of the QoL measure. A high waist circumference in men was associated with higher age and negatively associated with tobacco use and stigma score. In women it was negatively associated with never being married. A high prevalence of overweight and obesity was observed in HIV-clinics in South Africa, mainly in women. Since overweight and obesity are important health risk factors, effective weight reduction interventions are desirable.
C1 [' t Veld, Diana Huis In; Colebunders, Robert] Univ Antwerp, Dept Epidemiol & Social Med, Antwerp, Belgium.
   [' t Veld, Diana Huis In] FWO Res Fdn Flanders, Brussels, Belgium.
   [' t Veld, Diana Huis In; Colebunders, Robert] Inst Trop Med, Dept Clin Sci, Antwerp, Belgium.
   [Pengpid, Supa; Peltzer, Karl] Mahidol Univ, ASEAN Inst Hlth Dev, Nakhon Pathom, Thailand.
   [Pengpid, Supa] Univ Limpopo, Dept Res & Innovat, Sovenga, South Africa.
   [Peltzer, Karl] Human Sci Res Council, HIV AIDS STIs & TB HAST Res Programme, Pretoria, South Africa.
   [Peltzer, Karl] Univ Limpopo, Dept Psychol, Sovenga, South Africa.
   [' t Veld, Diana Huis In] Algemeen Inwendige Geneeskunde, De Pintelaan 185, B-9000 Ghent, Belgium.
C3 University of Antwerp; Institute of Tropical Medicine (ITM); Mahidol
   University; University of Limpopo; Human Sciences Research Council-South
   Africa; University of Limpopo; Ghent University; Ghent University
   Hospital
RP 't Veld, DHI (corresponding author), Univ Antwerp, Dept Epidemiol & Social Med, Antwerp, Belgium.; 't Veld, DHI (corresponding author), FWO Res Fdn Flanders, Brussels, Belgium.; 't Veld, DHI (corresponding author), Inst Trop Med, Dept Clin Sci, Antwerp, Belgium.; 't Veld, DHI (corresponding author), Algemeen Inwendige Geneeskunde, De Pintelaan 185, B-9000 Ghent, Belgium.
EM diana.huisintveld@uzgent.be
RI Pengpid, Supa/D-6031-2019; Mayanja-Kizza, Harriet/AAM-5372-2020;
   Peltzer, Karl/D-1518-2019; Huis in 't Veld, Diana/IAM-1219-2023
OI Peltzer, Karl/0000-0002-5980-0876; Huis in 't Veld,
   Diana/0000-0002-5806-4352; Colebunders, Robert/0000-0002-1919-1340
FU ABMRF; Foundation for Alcohol Research; Directorate Generale for
   Development Cooperation through the Flemish Interuniversity Council
   (VLIRUOS)
FX This study was funded by ABMRF, the Foundation for Alcohol Research and
   the Directorate Generale for Development Cooperation through the Flemish
   Interuniversity Council (VLIRUOS).
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NR 42
TC 13
Z9 13
U1 0
U2 16
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1090-7165
EI 1573-3254
J9 AIDS BEHAV
JI AIDS Behav.
PD JUN
PY 2018
VL 22
IS 6
BP 1972
EP 1986
DI 10.1007/s10461-017-1737-2
PG 15
WC Public, Environmental & Occupational Health; Social Sciences, Biomedical
WE Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; Biomedical Social Sciences
GA GG5DS
UT WOS:000432716100025
PM 28243935
DA 2025-06-11
ER

PT J
AU Corona, G
   Giorda, CB
   Cucinotta, D
   Guida, P
   Nada, E
AF Corona, Giovanni
   Giorda, Carlo B.
   Cucinotta, Domenico
   Guida, Piero
   Nada, Elisa
CA Grp Studio SUBITO-DE
TI Sexual Dysfunction at the Onset of Type 2 Diabetes: The Interplay of
   Depression, Hormonal and Cardiovascular Factors
SO JOURNAL OF SEXUAL MEDICINE
LA English
DT Article
DE Erectile Dysfunction; Testosterone; Diabetes Mellitus
ID ERECTILE DYSFUNCTION; PREMATURE EJACULATION; WEIGHT-LOSS; BIDIRECTIONAL
   ASSOCIATION; TESTOSTERONE DEFICIENCY; METABOLIC SYNDROME; RISK-FACTORS;
   MEN; METAANALYSIS; HYPOGONADISM
AB Introduction. Several data have emphasized the importance of early diagnosis of erectile dysfunction (ED) and meticulous cardiovascular investigation in the type 2 diabetic mellitus (T2DM) patients.
   Aim. To estimate the prevalence of ED and its associated determinants in a sample of male patients with new or recently diagnosed T2DM.
   Methods. The SUBITO-DE study is an observational, multicenter, prospective study involving 27 Italian diabetes centers. Male patients recently diagnosed with T2DM were consecutively interviewed by their attending physician at the diabetes care centers and asked whether they had experienced a change in their sexual function or found it unsatisfactory. Those responding positively were then invited to participate in the study.
   Main Outcome Measure. Several hormonal and biochemical parameters were studied.
   Results. A nonselected series of 1,503 patients was interviewed, 499 of which (mean age, 58.8 +/- 8.8 years) entered the study, yielding a final enrolment rate of 33.3%. ED was classified as mild in 19.4%, mild-to-moderate in 15.4%, moderate in 10.4%, and severe in 21.6% of patients, respectively. In addition, premature ejaculation, delayed ejaculation, and hypoactive sexual desire (HSD) were comorbid in 28.3%, 32.9%, and 58.4%, respectively. Finally, hypogonadism, showed an estimated prevalence of almost 20%. Both organic (at least one chronic DM-associated complication) and psychological factors (severe depressive symptoms) increased the risk of ED. Severe depressive symptoms were also associated with ejaculatory problems, HSD, and hypogonadism.
   Conclusions. A high prevalence of sexual dysfunction in men with recently diagnosed T2DM was detected. Early diagnosis of ED could help prevent emotional and physical discomfort in men and aid in identifying reversible cardiovascular risk factors. Screening of sexual dysfunction should become a part of routine care in the management of T2DM patients.
C1 [Corona, Giovanni] Maggiore Bellaria Hosp, Azienda USL Bologna, Endocrinol Unit, Dept Med, I-40133 Bologna, Italy.
   [Giorda, Carlo B.] ASL Turin, Metab & Diabet Unit, Turin, Italy.
   [Cucinotta, Domenico] 3 Policlin Messina, Dept Med, Messina, Italy.
   [Guida, Piero] Univ Bari, Cardiol Unit, Emergency & Organ Transplantat Dept, Bari, Italy.
   [Nada, Elisa] Chaira Med Assoc, Chieri, Italy.
C3 AUSL di Bologna; AOU Policlinico Gaetano Martino; Universita degli Studi
   di Bari Aldo Moro
RP Corona, G (corresponding author), Maggiore Bellaria Hosp, Azienda USL Bologna, Endocrinol Unit, Dept Med, Largo Nigrisoli 2, I-40133 Bologna, Italy.
EM jocorona@libero.it
RI cucinotta, domenico/F-4832-2014; giorda, carlo/D-4485-2018
OI giorda, carlo/0000-0002-4709-8696; CUCINOTTA, Domenico
   Maria/0000-0002-8159-5709; Guarino, Giuseppina/0000-0002-5057-9650;
   Viviani, Giorgio Luciano/0000-0002-5599-516X
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NR 42
TC 88
Z9 92
U1 0
U2 11
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1743-6095
EI 1743-6109
J9 J SEX MED
JI J. Sex. Med.
PD AUG
PY 2014
VL 11
IS 8
BP 2065
EP 2073
DI 10.1111/jsm.12601
PG 9
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA AN0CX
UT WOS:000340251000019
PM 25041930
DA 2025-06-11
ER

PT J
AU Geoffroy, PA
   Franchi, JAM
   Maruani, J
   Philip, P
   Boudebesse, C
   Benizri, C
   Yeim, S
   Benard, V
   Brochard, H
   Leboyer, M
   Bellivier, F
   Etain, B
AF Geoffroy, Pierre A.
   Franchi, Jean-Arthur Micoulaud
   Maruani, Julia
   Philip, Pierre
   Boudebesse, Carole
   Benizri, Chloe
   Yeim, Sunthavy
   Benard, Victoire
   Brochard, Helena
   Leboyer, Marion
   Bellivier, Frank
   Etain, Bruno
TI Clinical characteristics of obstructive sleep apnea in bipolar disorders
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Bipolar disorder; Sleep; Obesity; Depression; Circadian rhythms
ID MAJOR DEPRESSIVE DISORDER; CIRCADIAN TYPE INVENTORY;
   PSYCHIATRIC-DISORDERS; BERLIN QUESTIONNAIRE; METABOLIC SYNDROME;
   RISK-FACTORS; PREVALENCE; VALIDATION; SYMPTOMS; SCHIZOPHRENIA
AB Background: Obstructive sleep apnea (OSA) is one of the leading non-psychiatric comorbidities in bipolar disorders (BD). We sought to explore associations between risk of OSA in BD, clinical characteristics alongside with both subjective sleep complaints and objective sleep abnormalities.
   Methods: Euthymic patients with BD (n = 144) were assessed over a three-week period, by actigraphy, clinical interviews and questionnaires.
   Results: Of the study sample, 32 (22%) individuals were at high risk of OSA (HR-OSA) and 112 (78%) had a low risk (LR-OSA), as assessed with the Berlin questionnaire. HR-OSA, compared to LR-OSA, were older (p = 0.031), had higher BMI (p < 0.0005), larger neck circumference (p = 0.002), and more residual depressive symptoms (p < 0.0005). HR-OSA was also associated with greater sleepiness (p = 0.003), poorer sleep quality (p = 0.003), insomnia complaints (p = 0.027), "languid" chronotype (p = 0.002), and higher actigraphy-derived fragmentation index (p = 0.015). Backward stepwise linear regression retained BMI and depressive symptoms (correct classification of 83% of participants). Classification increased up to 85.4% when adding sleepiness and languid-vigorous scales and up to 87.8% when adding fragmentation index. Combining ROC curve analysis and Youden Index provided best cut-offs (HR-OSA if cut-off greater than or equal to) of 29.84 for BMI (Sensibility(Se) = 0.47, Specificity(Spe) = 0.96) and 1.5 for MADRS total score (Se = 0.84, Spe = 0.58). Limitations: No confirmation of OSA diagnosis with polysomnography.
   Conclusions: Higher BMI and residual depressive symptoms are the two best independent predictors of OSA in BD. Such information contributes to improving the screening and management of OSA in BD.
C1 [Geoffroy, Pierre A.; Maruani, Julia; Yeim, Sunthavy; Bellivier, Frank; Etain, Bruno] INSERM, U1144, F-75006 Paris, France.
   [Geoffroy, Pierre A.; Bellivier, Frank; Etain, Bruno] Univ Paris 05, UMR S 1144, F-75006 Paris, France.
   [Geoffroy, Pierre A.; Maruani, Julia; Yeim, Sunthavy; Bellivier, Frank; Etain, Bruno] Univ Paris Diderot, Sorbonne Paris Cite, UMR S 1144, F-75013 Paris, France.
   [Geoffroy, Pierre A.; Maruani, Julia; Yeim, Sunthavy; Bellivier, Frank; Etain, Bruno] GH St Louis Lariboisiere F Widal, AP HP, Pole Psychiat & Med Addictol, F-75475 Paris 10, France.
   [Geoffroy, Pierre A.; Maruani, Julia; Yeim, Sunthavy; Leboyer, Marion; Bellivier, Frank; Etain, Bruno] Fdn FondaMental, F-94000 Creteil, France.
   [Franchi, Jean-Arthur Micoulaud; Philip, Pierre] Univ Bordeaux, SANPSY, USR 3413, F-33000 Bordeaux, France.
   [Franchi, Jean-Arthur Micoulaud; Philip, Pierre] CNRS SANPSY, USR 3413, F-33000 Bordeaux, France.
   [Franchi, Jean-Arthur Micoulaud; Philip, Pierre] CHU Pellegrin, Clin Sommeil, Pl Amelie Raba Leon, F-33076 Bordeaux, France.
   [Boudebesse, Carole] Hop Univ Henri Mondor, AP HP, DHU Pepsy, Pole Psychiat & Addictol, Creteil, France.
   [Benizri, Chloe] Univ Paris Saclay, Univ Versailles St Quentin, UFR Sci Sante Simone Veil, Paris, France.
   [Benizri, Chloe] Ctr Hosp Versailles, Pole Psychiat, Versailles, France.
   [Benard, Victoire] Univ Lille, CHRU Lille, Clin Psychiat, Unite CURE, F-59000 Lille, France.
   [Benard, Victoire; Leboyer, Marion] Univ Lille, CNRS, CHU Lille, UMR 9193,SCALab Sci Cognit & Sci Affect, F-59000 Lille, France.
   [Brochard, Helena] Ctr Hosp Fdn Vallee, Pole Sectoriel, Gentilly, France.
C3 Universite Paris Cite; Institut National de la Sante et de la Recherche
   Medicale (Inserm); Universite Paris Cite; Universite Paris Cite;
   Assistance Publique Hopitaux Paris (APHP); Universite de Bordeaux;
   Centre National de la Recherche Scientifique (CNRS); CNRS - National
   Institute for Biology (INSB); Universite de Bordeaux; Centre National de
   la Recherche Scientifique (CNRS); CNRS - National Institute for Biology
   (INSB); CHU Bordeaux; Assistance Publique Hopitaux Paris (APHP);
   Universite Paris-Est-Creteil-Val-de-Marne (UPEC); Hopital Universitaire
   Henri-Mondor - APHP; Universite Paris Saclay; Universite Paris Saclay;
   Centre Hospitalier de Versailles; Universite de Lille; CHU Lille;
   Universite de Lille; CHU Lille; Centre National de la Recherche
   Scientifique (CNRS); CNRS - Institute for Humanities & Social Sciences
   (INSHS)
RP Geoffroy, PA (corresponding author), Hop Fernand Widal, Ctr Expert Troubles Bipolaires, 200 Rue Faubourg St Denis, F-75475 Paris 10, France.
EM pierre.a.geoffroy@gmail.com
RI PHILIP, PIERRE/AAS-8889-2020; Leboyer, Marion/AAW-3648-2021; Etain,
   Bruno/L-6647-2017; Geoffroy, Pierre Alexis/D-9743-2011
OI Etain, Bruno/0000-0002-5377-1488; Geoffroy, Pierre
   Alexis/0000-0001-9121-209X; PHILIP, Pierre/0000-0003-3267-634X
FU INSERM [C0829]; Assistance Publique des Hopitaux de Paris [GAN12];
   Investissements d'Avenir program [ANR-11-IDEX-0004]; Fondation
   FondaMental (RTRS Sante Mentale)
FX This work was supported by INSERM(Research Protocol C0829), Assistance
   Publique des Hopitaux de Paris (Research Protocol GAN12). This research
   was also supported by the Investissements d'Avenir program managed by
   the ANR under reference ANR-11-IDEX-0004 and Fondation FondaMental (RTRS
   Sante Mentale).
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NR 48
TC 13
Z9 14
U1 0
U2 5
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD FEB 15
PY 2019
VL 245
BP 1
EP 7
DI 10.1016/j.jad.2018.10.096
PG 7
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA HI8HR
UT WOS:000456697100001
PM 30359809
DA 2025-06-11
ER

PT J
AU Kahl, KG
   Bester, M
   Greggersen, W
   Rudolf, S
   Dibbelt, L
   Stoeckelhuber, BM
   Gehl, HB
   Sipos, V
   Hohagen, F
   Schweiger, U
AF Kahl, KG
   Bester, M
   Greggersen, W
   Rudolf, S
   Dibbelt, L
   Stoeckelhuber, BM
   Gehl, HB
   Sipos, V
   Hohagen, F
   Schweiger, U
TI Visceral fat deposition and insulin sensitivity in depressed women with
   and without comorbid borderline personality disorder
SO PSYCHOSOMATIC MEDICINE
LA English
DT Article
DE major depressive disorder; borderline personality disorder;
   hypothalamic-pituitary-adrenal system; interleukin-6; tumor necrosis
   factor-alpha alpha
ID NECROSIS-FACTOR-ALPHA; GLUCOSE-TOLERANCE; MAJOR DEPRESSION;
   ADIPOSE-TISSUE; CELL FUNCTION; RESISTANCE; INTERLEUKIN-6; EPIDEMIOLOGY;
   DISEASE; BIOLOGY
AB Objective: Major depressive disorder (MDD) is associated with increased intra-abdominal fat, an important antecedent of noninsulin-dependent diabetes mellitus (NIDDM) and cardiovascular disorders. Furthermore, MDD is commonly accompanied by endocrine and immune dysregulation that has also been discussed in connection with the pathogenesis of NIDDM and ischemic heart disease. In borderline personality disorder (BPD), a dysregulation of the hypothalamic-pituitary-adrenal system has also been described. Therefore, our study aimed at examining visceral fat, insulin resistance, and alterations of cortisol and cytokines in young depressed women with and without comorbid BPD. Methods: Visceral fat was measured in 18 premenopausal women with MDD and in 18 women comorbid with MDD and BPD by means of magnetic resonance tomography at the level of the first lumbar vertebral body. Twelve BPD patients without MDD and 20 healthy women served as the comparison groups. Concentrations of fasting cortisol, tumor necrosis factor-alpha, and interleukin-6 were measured, and indicators of insulin resistance and beta-cell sensitivity were calculated according to the homeostasis assessment model. Results: We found increased visceral fat in women comorbid with MDD and BPD, and to a lesser extent, in women with MDD but without BPD. Insulin sensitivity was reduced in comorbid patients. Serum interleukin-6 (IL-6) and tumor necrosis factor-a concentrations were significantly increased in both groups of depressed patients. Reduced insulin sensitivity correlated with the amount of visceral fat and with serum concentrations of IL-6. Conclusion: Young depressed women with and without comorbid BPD display increased visceral fat and may constitute a risk group for the development of NIDDM and the metabolic syndrome. Our data support the hypothesis that the immune and endocrine alterations associated with MDD and BPD may contribute to the pathophysiologic processes associated with NIDDM.
C1 Med Univ Lubeck, Klin Psychiat & Psychotherapie, Dept Psychiat & Psychotherapy, D-23538 Lubeck, Germany.
   Med Univ Lubeck, Inst Radiol, D-23538 Lubeck, Germany.
   Med Univ Lubeck, Inst Clin Chem, D-23538 Lubeck, Germany.
C3 University of Lubeck; University of Lubeck; University of Lubeck
RP Med Univ Lubeck, Klin Psychiat & Psychotherapie, Dept Psychiat & Psychotherapy, Ratzeburger Allee 160, D-23538 Lubeck, Germany.
EM kahl.k@psychiatry.uni-luebeck.de
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NR 42
TC 61
Z9 63
U1 0
U2 9
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0033-3174
EI 1534-7796
J9 PSYCHOSOM MED
JI Psychosom. Med.
PD MAY-JUN
PY 2005
VL 67
IS 3
BP 407
EP 412
DI 10.1097/01.psy.0000160458.95955.f4
PG 6
WC Psychiatry; Psychology; Psychology, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry; Psychology
GA 929MI
UT WOS:000229349800010
PM 15911903
DA 2025-06-11
ER

PT J
AU Martínez-González, MA
   Guillén-Grima, F
   De Irala, J
   Ruíz-Canela, M
   Bes-Rastrollo, M
   Beunza, JJ
   del Burgo, CL
   Toledo, E
   Carlos, S
   Sánchez-Villegas, A
AF Martinez-Gonzalez, Miguel A.
   Guillen-Grima, Francisco
   De Irala, Jokin
   Ruiz-Canela, Miguel
   Bes-Rastrollo, Maira
   Beunza, Juan J.
   Lopez del Burgo, Cristina
   Toledo, Estefania
   Carlos, Silvia
   Sanchez-Villegas, Almudena
TI The Mediterranean Diet Is Associated with a Reduction in Premature
   Mortality among Middle-Aged Adults
SO JOURNAL OF NUTRITION
LA English
DT Article
ID FOOD-FREQUENCY QUESTIONNAIRE; CORONARY-HEART-DISEASE; ALL-CAUSE
   MORTALITY; METABOLIC SYNDROME; RISK-FACTORS; LIFE-STYLE; ADHERENCE;
   PATTERNS; SURVIVAL; COHORT
AB The available large prospective studies supporting an inverse association between better adherence to the Mediterranean diet and lower mortality have mainly included older adults. It is not clear whether this inverse association is also present among younger individuals at lower mortality risk. Our aim was to assess the association between adherence to the Mediterranean diet and total mortality in middle-aged adults from the Seguimiento Universidad de Navarra (SUN) Project. We followed 15,535 Spanish university graduates for a mean of 6.8 y. Their mean age was 38 +/- 12 y, 59.6% were females, and all were initially free of cardiovascular disease, cancer, and diabetes. A validated FFQ was used to assess dietary habits. Adherence to the Mediterranean diet was categorized, into 3 groups according to the Mediterranean Diet Score (low, 0-2 points; moderate, 3-5 points; and high, 6-9 points). The outcome variable was total mortality. Cox proportional hazards models were used to estimate HR and 95% CI. We adjusted the estimates for sex, age, years of university education, BMI, smoking, physical activity, television watching, history of depression and baseline hypertension, and hypercholesterolemia. We observed 125 deaths during 105,980 person-years of follow-up. The fully adjusted HR for moderate and high adherence were 0.58(95% CI: 0.34, 0.99; P = 0.05) and 0.38 (95% CI: 0.21, 0.70; P = 0.002), respectively. For each 2-point increment in the Mediterranean Diet Score, the HR of death was 0.72 (95% CI: 0.58, 0.91; P = 0.006). Among highly educated, middle-aged adults, adherence to the traditional Mediterranean diet was associated with reduced risk of death. J. Nutr. 142: 1672-1678, 2012.
C1 [Martinez-Gonzalez, Miguel A.; Guillen-Grima, Francisco; De Irala, Jokin; Ruiz-Canela, Miguel; Bes-Rastrollo, Maira; Beunza, Juan J.; Lopez del Burgo, Cristina; Toledo, Estefania; Carlos, Silvia; Sanchez-Villegas, Almudena] Univ Navarra, Dept Prevent Med & Publ Hlth, E-31080 Pamplona, Spain.
   [Sanchez-Villegas, Almudena] Univ Las Palmas Gran Canaria, Dept Clin Sci, Las Palmas Gran Canaria, Spain.
C3 University of Navarra; Universidad de Las Palmas de Gran Canaria
RP Sánchez-Villegas, A (corresponding author), Univ Navarra, Dept Prevent Med & Publ Hlth, E-31080 Pamplona, Spain.
EM asanchez@dcc.ulpgc.es
RI Sanchez-Villegas, Almudena/T-6733-2019; CARLOS, SILVIA/L-9123-2014;
   Burgo, Cristina/I-1963-2017; Martinez-Gonzalez, Miguel/AAE-7669-2019;
   Beunza, Juan-Jose/ABF-4650-2020; Ruiz-Canela, Miguel/JYP-1794-2024;
   Martínez-González, Marina/R-6165-2016; Ruiz-Canela, Miguel/I-7738-2016;
   Guillen-Grima, FRANCISCO/H-3359-2012; BES-RASTROLLO, MAIRA/A-1329-2009;
   Toledo, Estefania/H-6211-2014; DE IRALA, JOKIN/H-2936-2017
OI Ruiz-Canela, Miguel/0000-0002-7684-2787; Lopez-del Burgo,
   Cristina/0000-0002-0074-2931; Guillen-Grima,
   FRANCISCO/0000-0001-9749-8076; Martinez-Gonzalez, Miguel
   A./0000-0002-3917-9808; BES-RASTROLLO, MAIRA/0000-0002-9139-4206;
   Beunza, Juan-Jose/0000-0001-8192-2952; Sanchez Villegas,
   Almudena/0000-0001-7733-9238; Toledo, Estefania/0000-0002-6263-4434; DE
   IRALA, JOKIN/0000-0002-7249-6581
FU Instituto De Salud Carlos III; Official Agency of the Spanish Government
   for biomedical research [PI010619, PI030678, PI040233, P1042241,
   P1050976, PI070240, PI070312, PI081943, PI080819, PI1002658, PI1002293,
   RD06/0045, G03/140, 87/2010]; Navarra Regional Government [36/2001,
   43/2002, 41/2005, 36/2008]; University of Navarra; Ministry of Economy
   and Competitiveness, Spanish Government
FX Supported by the Instituto De Salud Carlos III, Official Agency of the
   Spanish Government for biomedical research (grant nos. PI010619,
   PI030678, PI040233, P1042241, P1050976, PI070240, PI070312, PI081943,
   PI080819, PI1002658, PI1002293, RD06/0045, G03/140, and 87/2010), the
   Navarra Regional Government (36/2001, 43/2002, 41/2005, 36/2008), and
   the University of Navarra. E.T. is supported by a Rio Hortega
   postresidency fellowship of the Instituto de Salud Carlos III, Ministry
   of Economy and Competitiveness, Spanish Government.
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NR 42
TC 62
Z9 65
U1 0
U2 26
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0022-3166
EI 1541-6100
J9 J NUTR
JI J. Nutr.
PD SEP
PY 2012
VL 142
IS 9
BP 1672
EP 1678
DI 10.3945/jn.112.162891
PG 7
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 994CF
UT WOS:000307907800009
PM 22810987
OA Bronze
DA 2025-06-11
ER

PT J
AU Rej, S
   Li, BW
   Looper, K
   Segal, M
AF Rej, Soham
   Li, Brian Weixi
   Looper, Karl
   Segal, Marilyn
TI Renal function in geriatric psychiatry patients compared to
   non-psychiatric older adults: effects of lithium use and other factors
SO AGING & MENTAL HEALTH
LA English
DT Article
DE lithium; geriatric; longitudinal study; chronic renal failure; medical
   effects
ID CHRONIC KIDNEY-DISEASE; BIPOLAR DISORDER; METABOLIC SYNDROME;
   ELDERLY-PATIENTS; THERAPY; DISCONTINUATION; AUGMENTATION; METAANALYSIS;
   PREVALENCE; DEPRESSION
AB Objectives: Chronic renal failure is very common, affecting 30%-40% of community-dwelling elderly. We wished to verify whether geriatric psychiatry patients are at increased risk of renal dysfunction compared to elderly controls, as well as whether lithium exposure and other factors are important predictors of risk.
   Method: This is a four-year retrospective cohort and nested case-control study at a Canadian tertiary-care hospital using data from March 2007 to March 2011. We compared 82 geriatric psychiatry outpatients and 200 psychotropic-naive family medicine controls aged >= 65. Our main continuous measure of renal outcome was change in estimated glomerular filtration rate (eGFR). Multivariate analyses were performed to determine potential risk factors for renal dysfunction in geriatric psychiatry patients, including age, hypertension, diabetes mellitus, diuretics, and lithium duration.
   Results: Clinically important decreases in eGFR (>8 mL/min/1.73 m(2)) were found in 40.2% of geriatric psychiatry patients compared to 29.5% of controls (p = 0.040). Multivariate analyses found that lithium duration was independently associated with adverse renal outcome in patients with eGFR < 60 mL/min/1.73 m(2). In this sub-population, lithium users had clinically important decreases in eGFR when compared to non-lithium users: 10.3 vs. 0.40 mL/min/1.73 m(2) (p = 0.017).
   Conclusion: Geriatric psychiatry patients are at a greater risk for clinically important decreases of renal function than similarly aged controls. Lithium appears to be an important risk factor for renal dysfunction when eGFR is < 60 mL/min/1.73 m(2). However, in the majority of older adults who have normal kidney function, lithium use appears to be safe.
C1 [Rej, Soham; Looper, Karl; Segal, Marilyn] McGill Univ, Dept Psychiat, Montreal, PQ, Canada.
   [Li, Brian Weixi] McGill Univ, Dept Physiotherapy, Montreal, PQ, Canada.
   [Looper, Karl; Segal, Marilyn] McGill Univ, Jewish Gen Hosp, Dept Psychiat, Montreal, PQ H3T 1E2, Canada.
C3 McGill University; McGill University; Jewish General Hospital -
   Montreal; McGill University
RP Rej, S (corresponding author), McGill Univ, Dept Psychiat, Montreal, PQ, Canada.
EM soham.rej@mail.mcgill.ca
FU McGill University; Canadian Institutes of Health Research (CIHR);
   Federation de Recherche en Sante Quebec (FRSQ)
FX Brian Weixi Li received McGill University's Mr. and Mrs. John Henry
   Collins Memorial summer research bursary. Soham Rej is currently
   receiving Master's training awards from the Canadian Institutes of
   Health Research (CIHR) and the Federation de Recherche en Sante Quebec
   (FRSQ) for a separate project. There are no conflicts of interest to
   report.
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   Morikawa M, 2013, INT J GERIATR PSYCH, V28, P1251, DOI 10.1002/gps.3950
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NR 28
TC 11
Z9 11
U1 0
U2 9
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 1360-7863
EI 1364-6915
J9 AGING MENT HEALTH
JI Aging Ment. Health
PY 2014
VL 18
IS 7
BP 847
EP 853
DI 10.1080/13607863.2014.888536
PG 7
WC Geriatrics & Gerontology; Gerontology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Psychiatry
GA AM8EW
UT WOS:000340105900007
PM 24533667
DA 2025-06-11
ER

PT J
AU Williams, RB
   Surwit, RS
   Siegler, IC
   Ashley-Koch, AE
   Collins, AL
   Helms, MJ
   Georgiades, A
   Boyle, SH
   Brummett, BH
   Barefoot, JC
   Grichnik, K
   Stafford-Smith, M
   Kuhn, CM
AF Williams, Redford B.
   Surwit, Richard S.
   Siegler, Ilene C.
   Ashley-Koch, Allison E.
   Collins, Ann L.
   Helms, Michael J.
   Georgiades, Anastasia
   Boyle, Stephen H.
   Brummett, Beverly H.
   Barefoot, John C.
   Grichnik, Katherine
   Stafford-Smith, Mark
   Kuhn, Cynthia M.
TI Central Nervous System Serotonin and Clustering of Hostility,
   Psychosocial, Metabolic, and Cardiovascular Endophenotypes in Men
SO PSYCHOSOMATIC MEDICINE
LA English
DT Article
DE central nervous system; serotonin; cardiovascular risk factors;
   hostility; metabolic syndrome components; MAOA-uVNTR polymorphism
ID CORONARY-HEART-DISEASE; GLUCOSE-METABOLISM; RISK-FACTORS; MORTALITY;
   BEHAVIOR; HEALTH; CSF; VOLUNTEERS; DEPRESSION; SURVIVAL
AB Objective: To use measures of cerebrospinal fluid (CSF) 5-hydroxyindoleacetic acid (5HIAA) and genotype of a functional polymorphism of the monoamine oxidase A gene promoter (MAOA-uVNTR) to study the role of central nervous system (CNS) serotonin in clustering of hostility, other psychosocial, metabolic and cardiovascular endophenotypes. Methods: In 86 healthy male volunteers, we evaluated CSF levels of the primary serotonin metabolite 5HIAA and MAOA-uVNTR genotype for association with a panel of 29 variables assessing hostility, other psychosocial, metabolic, and cardiovascular endophenotypes. Results: The correlations of 5HIAA with these endophenotypes in men with more active MAOA-uVNTR alleles were significantly different from those of men with less active alleles for 15 of the 29 endophenotypes. MAOA-uVNTR genotype and CSF 5HIAA interacted to explain 20% and 22% of the variance, respectively, in scores on one factor wherein high scores reflected a less healthy psychosocial profile and a second factor wherein high score reflected increased insulin resistance, body mass index, blood pressure and hostility. In men with less active alleles, higher 5HIAA was associated with more favorable profiles of hostility, other psychosocial, metabolic and cardiovascular endophenotypes; in men with more active alleles, higher 5HIAA was associated with less favorable profiles. Conclusions: These findings indicate that, in men, indices of CNS serotonin function influence the expression and clustering of hostility, other psychosocial, metabolic and cardiovascular endophenotypes that have been shown to increase risk of developing cardiovascular disease. The findings are consistent with the hypothesis that increased CNS serotonin is associated with a more favorable psychosocial/metabolic/cardiovascular profile, whereas decreased CNS serotonin function is associated with a less favorable profile.
C1 [Williams, Redford B.; Surwit, Richard S.; Siegler, Ilene C.; Helms, Michael J.; Georgiades, Anastasia; Boyle, Stephen H.; Brummett, Beverly H.; Barefoot, John C.] Duke Univ, Med Ctr, Dept Psychiat & Behav Sci, Durham, NC 27710 USA.
   [Ashley-Koch, Allison E.; Collins, Ann L.] Duke Univ, Med Ctr, Dept Med, Durham, NC 27710 USA.
   [Grichnik, Katherine; Stafford-Smith, Mark] Duke Univ, Med Ctr, Dept Anesthesiol, Durham, NC 27710 USA.
   [Kuhn, Cynthia M.] Duke Univ, Med Ctr, Dept Pharmacol & Canc Biol, Durham, NC 27710 USA.
C3 Duke University; Duke University; Duke University; Duke University
RP Williams, RB (corresponding author), Duke Univ, Med Ctr, Dept Psychiat & Behav Sci, Box 3926, Durham, NC 27710 USA.
EM redfordw@duke.edu
RI Collins, Al/JCE-1766-2023; Suarez, Edward/HPE-3092-2023
OI Suarez, Edward/0000-0003-3069-5846; Ashley-Koch,
   Allison/0000-0001-5409-9155
FU National Heart, Lung, and Blood Institute [P01HL36587]; Clinical
   Research Unit [M01RR30]; Duke University Behavioral Medicine Research
   Center
FX This work was supported, in part, by Grant P01HL36587 (R.B.W.) from
   National Heart, Lung, and Blood Institute grant, Grant M01RR30 from
   Clinical Research Unit, and the Duke University Behavioral Medicine
   Research Center.
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NR 49
TC 9
Z9 10
U1 1
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0033-3174
J9 PSYCHOSOM MED
JI Psychosom. Med.
PD SEP
PY 2010
VL 72
IS 7
BP 601
EP 607
DI 10.1097/PSY.0b013e3181eb9d67
PG 7
WC Psychiatry; Psychology; Psychology, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry; Psychology
GA 653IY
UT WOS:000282084000001
PM 20595415
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Piras, M
   Lin, J
   Sadler, MC
   Ranjbar, S
   Grosu, C
   Laaboub, N
   Preisig, M
   Gamma, F
   Plessen, KJ
   von Gunten, A
   Conus, P
   Kutalik, Z
   Eap, CB
AF Piras, Marianna
   Lin, Jue
   Sadler, Marie Catherine
   Ranjbar, Setareh
   Grosu, Claire
   Laaboub, Nermine
   Preisig, Martin
   Gamma, Franziska
   Plessen, Kerstin Jessica
   von Gunten, Armin
   Conus, Philippe
   Kutalik, Zoltan
   Eap, Chin B.
TI Psychotropic-induced weight gain and telomere length: results from a
   one-year longitudinal study and a large population-based cohort
SO TRANSLATIONAL PSYCHIATRY
LA English
DT Article
ID C-REACTIVE PROTEIN; BODY-MASS INDEX; METABOLIC SYNDROME; SCHIZOPHRENIA;
   ASSOCIATION; ANTIPSYCHOTICS; DEPRESSION; DISORDERS; MORTALITY; RESPONSES
AB Weight-inducing psychotropic treatments are risk factors for age-related diseases such as cardiovascular disorders, which are associated with both inflammation and telomere length shortening. With a longitudinal design, the present study evaluates telomere length trajectories after 1 year of weight-inducing psychotropic medication, accounting for weight changes and the inflammatory biomarker high-sensitivity C-Reactive Protein (CRP). Among 200 patients, an overall median telomere shortening of -41.2 bp was observed (p = 0.014), which is comparable with the general population's yearly telomere attrition. Linear regression showed on average -93.1 and -58.9 bp of further telomere shortening per five units of BMI for BMI values < or >= 30 kg/m(2), respectively (p = 0.003 and p = 0.009, respectively). Importantly, the overall telomere shortening was predicted to be increased four-fold among patients with low baseline weight (i.e., 50 kg) and with clinically relevant weight gain (>= 7%) after 1 year of treatment (interaction term between relevant weight gain and baseline weight: +6.3 bp, p = 0.016). Patients with relevant weight gain showed greater CRP levels (+ 49%; p = 0.016), and a telomere shortening of -36.2 bp (p = 0.010) was estimated whenever CRP level doubled. Mendelian randomization using UKBiobank data showed a causal effect of BMI on telomere shortening, notably stronger among patients receiving weight-inducing psychotropic treatments (n = 9798) than among psychiatric patients without such drugs (n = 16228) and non-psychiatric controls (n = 252932) (beta: -0.37, -0.12, -0.06, respectively; p = 0.004, p < 0.001, p < 0.001, respectively). Ultimately, telomere trajectories were associated with 1 year weight gain and increases in CRP levels, with telomere shortening strongly enhanced by BMI increments among patients receiving weight-inducing psychotropic treatments.
C1 [Piras, Marianna; Grosu, Claire; Laaboub, Nermine; Eap, Chin B.] Univ Lausanne, Lausanne Univ Hosp, Ctr Psychiat Neurosci, Dept Psychiat,Unit Pharmacogenet & Clin Psychophar, Prilly, Switzerland.
   [Lin, Jue] Univ Calif San Francisco, Dept Biochem & Biophys, San Francisco, CA USA.
   [Sadler, Marie Catherine; Kutalik, Zoltan] Univ Lausanne, Univ Ctr Primary Care & Publ Hlth, Lausanne, Switzerland.
   [Sadler, Marie Catherine; Kutalik, Zoltan] Univ Lausanne, Dept Computat Biol, Lausanne, Switzerland.
   [Sadler, Marie Catherine; Kutalik, Zoltan] Swiss Inst Bioinformat, Lausanne, Switzerland.
   [Ranjbar, Setareh; Preisig, Martin] Univ Lausanne, Lausanne Univ Hosp, Psychiat Epidemiol & Psychopathol Res Ctr, Dept Psychiat, Prilly, Switzerland.
   [Gamma, Franziska] Les Toises Psychiat & Psychotherapy Ctr, Lausanne, Switzerland.
   [Plessen, Kerstin Jessica] Univ Lausanne, Lausanne Univ Hosp, Dept Psychiat, Serv Child & Adolescent Psychiat, Lausanne, Prilly, Switzerland.
   [von Gunten, Armin] Univ Lausanne, Lausanne Univ Hosp, Dept Psychiat, Serv Old Age Psychiat, Lausanne, Prilly, Switzerland.
   [Conus, Philippe] Univ Lausanne, Lausanne Univ Hosp, Dept Psychiat, Serv Gen Psychiat, Lausanne, Prilly, Switzerland.
   [Eap, Chin B.] Univ Geneva, Univ Lausanne, Sch Pharmaceut Sci, Geneva, Switzerland.
   [Eap, Chin B.] Univ Lausanne, Ctr Res & Innovat Clin Pharmaceut Sci, Lausanne, Switzerland.
   [Eap, Chin B.] Univ Lausanne, Univ Geneva, Inst Pharmaceut Sci Western Switzerland, Lausanne, Switzerland.
C3 University of Lausanne; University of California System; University of
   California San Francisco; University of Lausanne; University of
   Lausanne; Swiss Institute of Bioinformatics; University of Lausanne;
   University of Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV);
   University of Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV);
   University of Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV);
   University of Geneva; University of Lausanne; University of Lausanne;
   University of Lausanne; University of Geneva
RP Piras, M; Eap, CB (corresponding author), Univ Lausanne, Lausanne Univ Hosp, Ctr Psychiat Neurosci, Dept Psychiat,Unit Pharmacogenet & Clin Psychophar, Prilly, Switzerland.; Eap, CB (corresponding author), Univ Geneva, Univ Lausanne, Sch Pharmaceut Sci, Geneva, Switzerland.; Eap, CB (corresponding author), Univ Lausanne, Ctr Res & Innovat Clin Pharmaceut Sci, Lausanne, Switzerland.; Eap, CB (corresponding author), Univ Lausanne, Univ Geneva, Inst Pharmaceut Sci Western Switzerland, Lausanne, Switzerland.
EM Marianna.piras@chuv.ch; chinbin.eap@unil.ch
RI Preisig, Martin/H-3441-2016; Kutalik, Zoltan/HHZ-5697-2022; Ranjbar,
   Setareh/KRP-6906-2024
OI LAABOUB, Nermine/0000-0001-8029-2418; Sadler, Marie
   C./0000-0002-2599-9207; Ranjbar, Setareh/0000-0002-0238-2976; Preisig,
   Martin/0000-0001-5689-4259; von Gunten, Armin/0000-0001-7852-3803
FU Funding: Swiss National Research Foundation (CE and PC: 320030-120686,
   324730- 144064, and 320030-173211; CBE, PC and KJP: 320030-200602; ZK:
   310030-189147). [2024]; Swiss National Research Foundation
FX This study was supported by the Swiss National Research Foundation. The
   authors thank A.C. Aubert, M. Brocard and S. Jaquet for C-Reactive
   Protein and DNA extraction analysis (Lausanne University Hospital,
   Lausanne, Switzerland) and L. Maw for editorial assistance. None have
   conflicts of interest to declare. The authors thank the nursing and
   medical staff involved in the data collection. Part of the results of
   the present manuscript was presented at the WorldCongress of Societies
   of Biological Psychiatry (2024, June 5-8, Istanbul, Turkey).
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NR 40
TC 1
Z9 1
U1 1
U2 1
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 2158-3188
J9 TRANSL PSYCHIAT
JI Transl. Psychiatr.
PD NOV 15
PY 2024
VL 14
IS 1
AR 471
DI 10.1038/s41398-024-03177-3
PG 10
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychiatry
GA M2W3C
UT WOS:001356190200001
PM 39548087
OA gold
DA 2025-06-11
ER

PT J
AU Garcia-Rizo, C
   Casanovas, M
   Fernandez-Egea, E
   Oliveira, C
   Meseguer, A
   Cabrera, B
   Mezquida, G
   Bioque, M
   Kirkpatrick, B
   Bernardo, M
AF Garcia-Rizo, Clemente
   Casanovas, Marta
   Fernandez-Egea, Emilio
   Oliveira, Cristina
   Meseguer, Ana
   Cabrera, Bibiana
   Mezquida, Gisela
   Bioque, Miquel
   Kirkpatrick, Brian
   Bernardo, Miquel
TI Blood cell count in antipsychotic-naive patients with non-affective
   psychosis
SO EARLY INTERVENTION IN PSYCHIATRY
LA English
DT Article
DE drug naive; metabolic disturbances; metabolic syndrome; monocyte count;
   neutrophil count; non-affective psychosis; schizophrenia; WBC count
ID CARDIOVASCULAR-DISEASE; LYMPHOCYTE SUBSETS; SCHIZOPHRENIA; RISK;
   PSYCHOPATHOLOGY; DEPRESSION; LEUKOCYTES; SCALE
AB Background Schizophrenia is a complex medical entity with a reduced life expectancy, mostly due to an increased prevalence of cardiovascular diseases compared to the general population. An unbalanced immune response and a pro-inflammatory state might underlie this process. In treated patients, abnormal white blood cell (WBC), lymphocyte and neutrophil count suggests atypical immune response related to clinical variables. We aimed to test the hypothesis that newly diagnosed naive patients with non-affective psychosis would show abnormal blood cell count values after controlling for potential confounding factors compared to matched controls. Methods Seventy-five patients were compared with 80 controls matched for age, gender, body mass index and smoking. Analyses were conducted before and after controlling for smoking. Results Patients and controls displayed similar mean values (x10(3)/mu L [SD]) for WBC count 7.02 [2.2] vs 6.50 [1.7] (P = .159), neutrophil count 4.25 [1.8] vs 3.84 [1.3] (P = .110) and monocyte count 0.43 [0.2] vs 0.40 [0.1] (P = .326). After controlling for smoking, 38 non-smoking patients showed a higher WBC and neutrophil count compared with 49 matched controls. Respective means of 7.01 [2.2] vs 5.97 [1.4] (P = .011) for WBC and 4.24 [1.9] vs 3.51 [1.2] (P = .028) for neutrophil count. Monocyte count showed an increased mean value 0.43 [0.2] vs 0.36 [0.1] with a trend towards signification (P = .063). Conclusions These results suggest that abnormal immune response is present before the effects of medication and other confounders had taken place. Increased immune parameters might underlie the high ratio of medical co-morbidities described in schizophrenia.
C1 [Garcia-Rizo, Clemente; Oliveira, Cristina; Meseguer, Ana; Cabrera, Bibiana; Mezquida, Gisela; Bioque, Miquel; Bernardo, Miquel] Hosp Clin Barcelona, Neurosci Inst, Barcelona Clin Schizophrenia Unit, Barcelona, Spain.
   [Garcia-Rizo, Clemente; Bernardo, Miquel] August Pi i Sunyer Biomed Res Inst IDIBAPS, Barcelona, Spain.
   [Garcia-Rizo, Clemente; Fernandez-Egea, Emilio; Cabrera, Bibiana; Bioque, Miquel; Bernardo, Miquel] Ctr Biomed Res Mental Hlth Network CIBERSAM, Madrid, Spain.
   [Casanovas, Marta] Autonomous Univ Barcelona, Vall dHebron Univ Hosp, Dept Psychiat, Barcelona, Spain.
   [Fernandez-Egea, Emilio] Univ Cambridge, Addenbrookes Hosp, Dept Psychiat, Cambridge, England.
   [Fernandez-Egea, Emilio] Cambridgeshire & Peterborough NHS Fdn Trust, Huntingdon, England.
   [Kirkpatrick, Brian] Univ Nevada, Sch Med, Dept Psychiat & Behav Sci, Reno, NV 89557 USA.
   [Bernardo, Miquel] Univ Barcelona, Dept Med, Barcelona, Spain.
C3 University of Barcelona; Hospital Clinic de Barcelona; University of
   Barcelona; Hospital Clinic de Barcelona; IDIBAPS; CIBER - Centro de
   Investigacion Biomedica en Red; CIBERSAM; Hospital Universitari Vall
   d'Hebron; Autonomous University of Barcelona; Cambridge University
   Hospitals NHS Foundation Trust; Addenbrooke's Hospital; University of
   Cambridge; Nevada System of Higher Education (NSHE); University of
   Nevada Reno; University of Barcelona
RP Garcia-Rizo, C (corresponding author), Barcelona Clin Schizophrenia Unit, Villarroel 170, Barcelona 08036, Spain.
EM cgarcia3@clinic.ub.es
RI Mezquida, Gisela/HTQ-9777-2023; garcia-rizo, clemente/C-5520-2019;
   Bioque, Miquel/ACC-0014-2022; Bernardo, Miquel/P-3049-2015
OI Fernandez-Egea, Emilio/0000-0003-4128-8955; garcia-rizo,
   clemente/0000-0002-4855-1608; Bioque, Miquel/0000-0001-6887-7149;
   Mezquida Mateos, Gisela/0000-0002-6080-2203; Bernardo,
   Miquel/0000-0001-8748-6717
FU National Institute of Diabetes and Digestive and Kidney Diseases [RO1
   DK069265]; NARSAD project [PI14/00753]; ISCIII-General Evaluation
   Branch; European Regional Development Fund (FEDER); Instituto de Salud
   Carlos III, FEDER; Centro de Investigacion Biomedica en Red de salud
   Mental, CIBERSAM; Government of Catalonia, Comissionat per Universitats
   i Recerca del Department d'Innovacio, Universitats i Empresa (DIUE)
   [2014SGR441]; FI-DGR-2013 Contract of the Agencia de Gestio d'Ajuts
   Universitaris i de Recerca, AGAUR [2015 FI_B2 00100]; Esther Koplowitz
   Center-Barcelona; Genus Pharmaceuticals
FX National Institute of Diabetes and Digestive and Kidney Diseases,
   Grant/Award number: RO1 DK069265; NARSAD PI14/00753 project;
   ISCIII-General Evaluation Branch and the European Regional Development
   Fund (FEDER); Instituto de Salud Carlos III, FEDER; Centro de
   Investigacion Biomedica en Red de salud Mental, CIBERSAM; Government of
   Catalonia, Comissionat per Universitats i Recerca del Department
   d'Innovacio, Universitats i Empresa (DIUE), Grant/Award number:
   2014SGR441; FI-DGR-2013 Contract of the Agencia de Gestio d'Ajuts
   Universitaris i de Recerca, AGAUR, Grant/Award number: 2015 FI_B2 00100;
   Esther Koplowitz Center-Barcelona; Genus Pharmaceuticals.
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NR 45
TC 34
Z9 35
U1 0
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1751-7885
EI 1751-7893
J9 EARLY INTERV PSYCHIA
JI Early Interv. Psychiatry
PD FEB
PY 2019
VL 13
IS 1
BP 95
EP 100
DI 10.1111/eip.12456
PG 6
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA HG5UE
UT WOS:000455043800013
PM 28786532
DA 2025-06-11
ER

PT J
AU Crum-Cianflone, NF
   Bavaro, M
   Hale, B
   Amling, C
   Truett, A
   Brandt, C
   Pope, B
   Furtek, K
   Medina, S
   Wallace, MR
AF Crum-Cianflone, Nancy F.
   Bavaro, Mary
   Hale, Braden
   Amling, Christopher
   Truett, April
   Brandt, Carolyn
   Pope, Brandie
   Furtek, Kari
   Medina, Sheila
   Wallace, Mark R.
TI Erectile dysfunction and hypogonadism among men with HIV
SO AIDS PATIENT CARE AND STDS
LA English
DT Article
ID HUMAN-IMMUNODEFICIENCY-VIRUS; ACTIVE ANTIRETROVIRAL THERAPY; MIDDLE-AGED
   MEN; SEXUAL DYSFUNCTION; PROTEASE INHIBITORS; ANDROGEN DEFICIENCY;
   INFECTED MEN; METABOLIC SYNDROME; TESTOSTERONE REPLACEMENT; SILDENAFIL
   USE
AB Erectile dysfunction (ED) and hypogonadism are increasingly recognized conditions, however, the prevalence and etiologies of these conditions among HIV-infected men remain unclear. We studied 300 HIV-infected men who completed standardized questionnaires regarding sexual function and hypogonadal symptoms. An early morning testosterone test was performed; patients with a low serum testosterone level ( defined by < 300 ng/dL), underwent additional blood tests to determine the etiology of the hypogonadism. The participants' mean age was 39 years ( range, 19-72); 61% were Caucasian; 24%, African American; 9%, Hispanic; and 5% other. Participants had been HIV-positive for a mean of 9 years ( range, 0.5-20) with a mean CD4 count of 522 cells/mm(3) ( range, 1-1531). Sixty percent were receiving antiretroviral therapy. ED was reported by 61.4%; of those with ED, 32% did not have a rigid enough erection for penetration, and 46% were unable to sustain an erection for the completion of intercourse. In the multivariate analysis, increasing age ( odds ratio [ OR] 1.4 for a 5-year increment, p < 0.001) and depression ( OR 2.64, p < 0.0001) were associated with ED. A higher current CD4 count was protective ( OR 0.80 for each 100 cells/mm(3), p = 0.004). Only 25% of patients with ED had utilized a phosphodiesterase-5-inhibitor for treatment. Seventeen percent of the 300 men were hypogonadal; there was no correlation between hypogonadism and ED. Increasing age and a higher body mass index (BMI) were positively associated with hypogonadism, while smoking was negatively associated ( OR 0.44, p = 0.02). All patients with low testosterone had secondary hypogonadism. There was no association between ED or hypogonadism with the current, past, or cumulative use of HIV medications.
C1 USN, Clin Invest Dept KCA, San Diego Med Ctr, San Diego, CA 92134 USA.
   Tri Serv AIDS Clin Consortium, Rockville, MD USA.
   USN, Dept Urol, San Diego Med Ctr, San Diego, CA 92134 USA.
C3 United States Department of Defense; United States Navy; United States
   Department of Defense; United States Navy
RP Crum-Cianflone, NF (corresponding author), USN, Clin Invest Dept KCA, San Diego Med Ctr, 34800 Bob Wilson Dr,Suite 5, San Diego, CA 92134 USA.
EM NFCrum@nmcsd.med.navy.mil
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NR 51
TC 79
Z9 84
U1 0
U2 4
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1087-2914
EI 1557-7449
J9 AIDS PATIENT CARE ST
JI Aids Patient Care STDS
PD JAN
PY 2007
VL 21
IS 1
BP 9
EP 19
DI 10.1089/apc.2006.0071
PG 11
WC Public, Environmental & Occupational Health; Infectious Diseases
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; Infectious Diseases
GA 133RT
UT WOS:000244031400003
PM 17263654
DA 2025-06-11
ER

PT J
AU Jafari, RS
   Behrouz, V
AF Jafari, Reyhaneh Sadat
   Behrouz, Vahideh
TI Nordic diet and its benefits in neurological function: a systematic
   review of observational and intervention studies
SO FRONTIERS IN NUTRITION
LA English
DT Review
DE diet; Nordic; brain; neuroprotection; cognition
ID BALTIC SEA DIET; NF-KAPPA-B; HIGH-CARBOHYDRATE DIETS; BETA-GLUCAN
   CONTENT; FOOD INDEX; MEDITERRANEAN DIET; HEALTH-BENEFITS; INFLAMMATORY
   RESPONSES; DEPRESSIVE SYMPTOMS; METABOLIC SYNDROME
AB Introduction Neurological disorders have been considered the major contributors to global long-term disability and lower quality of life. Lifestyle factors, such as dietary patterns, are increasingly recognized as important determinants of neurological function. Some dietary behaviors, such as Nordic diet (ND) were likely to have protective effects on brain function. However, an understanding of the effectiveness of the ND pattern to improve neurological function and brain health is not fully understood. We review the current evidence that supports the ND pattern in various aspects of neurological function and addresses both proven and less established mechanisms of action based on its food ingredients and biochemical compounds.Methods In this systematic review, PubMed, Web of Science, and Scopus databases were searched from inception to February 2023. Observational and intervention studies were included.Results Of the 627 screened studies, 5 observational studies (including three cohorts and two cross-sectional studies) and 3 intervention studies investigating the association between ND and neurological function. Observational studies investigated the association of ND with the following neurological functions: cognition, stroke, and neuropsychological function. Intervention studies investigated the effects of ND on cognition and depression.Discussion Despite the limited literature on ND and its association with neurological function, several aspects of ND may lead to some health benefits suggesting neuroprotective effects. The current state of knowledge attributes the possible effects of characteristic components of the ND to its antioxidant, anti-inflammatory, lipid-lowering, gut-brain-axis modulating, and ligand activities in cell signaling pathways. Based on existing evidence, the ND may be considered a recommended dietary approach for the improvement of neurological function and brain health.
C1 [Jafari, Reyhaneh Sadat] Kerman Univ Med Sci, Student Res Comm, Kerman, Iran.
   [Behrouz, Vahideh] Kerman Univ Med Sci, Fac Publ Hlth, Dept Nutr, Kerman, Iran.
C3 Kerman University of Medical Sciences; Kerman University of Medical
   Sciences
RP Behrouz, V (corresponding author), Kerman Univ Med Sci, Fac Publ Hlth, Dept Nutr, Kerman, Iran.
EM vahideh.behrouz@gmail.com
RI behrouz, vahideh/AAL-5105-2020
FU This article is the result of the research project approved by the
   student research committee of Kerman University of Medical Sciences
   under the number 401000952 which was carried out with the financial
   support of the research and technology vice-chancello; Kerman University
   of Medical Sciences;  [401000952]
FX This article is the result of the research project approved by the
   student research committee of Kerman University of Medical Sciences
   under the number 401000952 which was carried out with the financial
   support of the research and technology vice-chancellor of this
   university.
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NR 142
TC 8
Z9 8
U1 2
U2 9
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD AUG 14
PY 2023
VL 10
AR 1215358
DI 10.3389/fnut.2023.1215358
PG 14
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA Q1EK5
UT WOS:001055015400001
PM 37645628
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Benham, JL
   Booth, JE
   Goldfield, G
   Friedenreich, CM
   Rabi, DM
   Sigal, RJ
AF Benham, Jamie L.
   Booth, Jane E.
   Goldfield, Gary
   Friedenreich, Christine M.
   Rabi, Doreen M.
   Sigal, Ronald J.
TI Self-reported sleep quality and exercise in polycystic ovary syndrome: A
   secondary analysis of a pilot randomized controlled trial
SO CLINICAL ENDOCRINOLOGY
LA English
DT Article
DE exercise; high-intensity interval training; polycystic ovary syndrome;
   randomized controlled trial; sleep; sleep quality; women's health
ID METABOLIC SYNDROME; PHYSICAL-ACTIVITY; WOMEN; DISTURBANCES; DEPRESSION;
   INDEX; ASSOCIATION; PREVALENCE; SAMPLE; ADULTS
AB ObjectiveTo examine the proportion of participants with poor sleep quality, evaluate the associations between sleep quality and anthropometric and cardiometabolic health markers, and evaluate the effect of high intensity interval training (HIIT) and continuous aerobic exercise training (CAET) on sleep quality in polycystic ovary syndrome (PCOS). DesignSecondary analysis of a pilot randomized controlled trial. PatientsWomen with PCOS aged 18-40 years. MeasurementsThe Pittsburgh Sleep Quality Index (PSQI) was measured at baseline and following a 6-month exercise intervention. A PSQI score >5 indicates poor sleep. Linear regression was used to evaluate the associations between PSQI score and anthropometric and cardiometabolic health markers, and the effect of exercise training on these associations. ResultsThirty-four participants completed the PSQI at baseline, and 29 postintervention: no-exercise control (n = 9), HIIT (n = 12) and CAET (n = 8). At baseline, 79% had poor sleep quality. Baseline PSQI score was positively correlated with body mass index, waist circumference, body weight, haemoglobin A1c and insulin resistance. Mean PSQI score changes were -0.4 (SD 1.1), -0.7 (SD 0.6) and -0.5 (SD 0.9) for control, HIIT and CAET, respectively. For HIIT participants, change in PSQI score was associated with changes in body weight (B = .27, 95% CI 0.10-0.45) and waist circumference (B = .09, 95% CI 0.02-0.17). ConclusionMost participants had poor sleep quality which was associated with poorer anthropometric and cardiometabolic health markers. There were no statistically significant changes in PSQI score with exercise training. With HIIT training, decreases in the sleep efficiency score were associated with reductions in body weight and waist circumference. Further studies are needed to determine the effect of exercise training on sleep quality.
C1 [Benham, Jamie L.; Rabi, Doreen M.; Sigal, Ronald J.] Univ Calgary, Cumming Sch Med, Dept Med, Calgary, AB, Canada.
   [Benham, Jamie L.; Booth, Jane E.; Friedenreich, Christine M.; Rabi, Doreen M.; Sigal, Ronald J.] Univ Calgary, Cumming Sch Med, Dept Community Hlth Sci, Calgary, AB, Canada.
   [Goldfield, Gary] Childrens Hosp Eastern Ontario Res Inst, Ottawa, ON, Canada.
   [Friedenreich, Christine M.] Alberta Hlth Serv, Dept Canc Epidemiol & Prevent Res, Canc Care Alberta, Calgary, AB, Canada.
   [Friedenreich, Christine M.; Sigal, Ronald J.] Univ Calgary, Fac Kinesiol, Calgary, AB, Canada.
   [Friedenreich, Christine M.] Univ Calgary, Cumming Sch Med, Dept Oncol, Calgary, AB, Canada.
   [Rabi, Doreen M.; Sigal, Ronald J.] Univ Calgary, Cumming Sch Med, Dept Cardiac Sci, Calgary, AB, Canada.
   [Benham, Jamie L.] Univ Calgary, Dept Med, Div Endocrinol & Metab, 3280 Hosp Dr NW, Calgary, AB T2N 4Z6, Canada.
C3 University of Calgary; University of Calgary; University of Ottawa;
   Children's Hospital of Eastern Ontario; University of Calgary; Alberta
   Health Services (AHS); University of Calgary; University of Calgary;
   University of Calgary; University of Calgary
RP Benham, JL (corresponding author), Univ Calgary, Dept Med, Div Endocrinol & Metab, 3280 Hosp Dr NW, Calgary, AB T2N 4Z6, Canada.
EM jlbenham@ucalgary.ca
RI Friedenreich, Christine/LKJ-4397-2024; Benham, Jamie/KFS-9089-2024;
   Sigal, Ron/AAK-7627-2020
OI Benham, Jamie L/0000-0002-2233-4613
FU Libin Cardiovascular Institute, University of Calgary; Canadian Society
   of Endocrinology and Metabolism; Cumming School of Medicine, University
   of Calgary/Alberta Health Services Clinical Research Fund
FX Libin Cardiovascular Institute, University of Calgary; Canadian Society
   of Endocrinology and Metabolism; Cumming School of Medicine, University
   of Calgary/Alberta Health Services Clinical Research Fund
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NR 40
TC 5
Z9 5
U1 4
U2 16
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0300-0664
EI 1365-2265
J9 CLIN ENDOCRINOL
JI Clin. Endocrinol.
PD MAY
PY 2023
VL 98
IS 5
BP 700
EP 708
DI 10.1111/cen.14900
EA MAR 2023
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA C4LM7
UT WOS:000943878500001
PM 36843192
OA hybrid
DA 2025-06-11
ER

PT J
AU Han, KM
   Lee, HJ
   Kim, L
   Yoon, HK
AF Han, Kyu-Man
   Lee, Heon-Jeong
   Kim, Leen
   Yoon, Ho-Kyoung
TI Association between weekend catch-up sleep and high-sensitivity
   C-reactive protein levels in adults: a population-based study
SO SLEEP
LA English
DT Article
DE weekend catch-up sleep; sleep duration; high-sensitivity C-reactive
   protein; inflammation; obesity
ID KOREA NATIONAL-HEALTH; INFLAMMATORY MARKERS; CARDIOVASCULAR-DISEASE;
   METABOLIC SYNDROME; SUICIDAL IDEATION; DURATION; DEPRESSION; OBESITY;
   SEVERITY; INTERLEUKIN-6
AB Study Objectives: To investigate the association between weekend catch-up sleep (WCS) and the levels of high-sensitivity C-reactive protein (hsCRP)-a serum inflammatory maker-in adults
   Methods: Data of 5,506 adults aged 19 years or older were obtained from the nationwide cross-sectional Korea National Health and Nutrition Examination Surveys conducted in 2016. Serum hsCRP level, weekday and weekend sleep durations, and sociodemographic and health-related characteristics were assessed. Participants whose weekend sleep duration was more than 1 h longer than their weekday sleep duration were included in the WCS group. hsCRP level was categorized into quartiles (i.e. highest, middle-high, middle-low, and lowest). Obesity was defined by body mass index >= 25.0 kg/m(2).
   Results: The WCS group included 1,901 participants (34.5%). In the logistic regression analysis controlling for all variables, adults in the WCS group were significantly less likely to show the highest hsCRP level (versus the lowest level) compared with those without WCS in the complete sample (adjusted odds ratio = 0.795, 95% confidence interval [CI] = 0.662 to 0.955). In a subgroup analysis, this association was significant only for those with weekday sleep duration of 6 h or lower. Longer WCS h) was not associated with hsCRP levels. Non-obese people with WCS demonstrated a lower risk for high hsCRP levels, while there was no significant difference in obese people with WCS.
   Conclusions: Our findings indicate that WCS may be beneficial for low-grade systemic inflammation in adults, particularly among those with shorter weekday sleep durations. WCS may also interact with obesity.
C1 [Han, Kyu-Man; Lee, Heon-Jeong; Kim, Leen; Yoon, Ho-Kyoung] Korea Univ, Coll Med, Dept Psychiat, Seoul, South Korea.
C3 Korea University; Korea University Medicine (KU Medicine)
RP Yoon, HK (corresponding author), Korea Univ, Ansan Hosp, Coll Med, Dept Psychiat, 123 Jeokgeum Ro, Ansan 15355, South Korea.
EM hkhkgogo@korea.ac.kr
RI ; Lee, Heon-Jeong/K-5871-2015
OI Han, Kyu-Man/0000-0002-1982-4216; Lee, Heon-Jeong/0000-0002-9560-2383
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NR 52
TC 36
Z9 36
U1 5
U2 18
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0161-8105
EI 1550-9109
J9 SLEEP
JI Sleep
PD AUG
PY 2020
VL 43
IS 8
AR zsaa010
DI 10.1093/sleep/zsaa010
PG 11
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology
GA OW9DC
UT WOS:000593177200001
PM 32006432
OA Bronze
DA 2025-06-11
ER

PT J
AU Lane-Cordova, AD
   Kershaw, K
   Liu, K
   Herrington, D
   Lloyd-Jones, DM
AF Lane-Cordova, Abbi D.
   Kershaw, Kiarri
   Liu, Kiang
   Herrington, David
   Lloyd-Jones, Donald M.
TI Association Between Cardiovascular Health and Endothelial Function With
   Future Erectile Dysfunction: The Multi-Ethnic Study of Atherosclerosis
SO AMERICAN JOURNAL OF HYPERTENSION
LA English
DT Article
DE blood pressure; cardiovascular health; erectile dysfunction;
   flow-mediated dilation; hypertension
ID METABOLIC SYNDROME; PHYSICAL-ACTIVITY; RISK-FACTORS; DISEASE; IMPACT;
   CANCER; ADULTS; MEN
AB BACKGROUND
   The association of Cardiovascular Health (CVH; defined by the American Heart Association by assigning points for health-related behavioral and clinical factors) with endothelial and erectile dysfunction has not been reported, although endothelial and erectile dysfunction have been associated with components of CVH.
   METHODS
   Data were collected in 1,136 men in the Multi-Ethnic Study of Atherosclerosis at baseline and erectile dysfunction status (measured by survey or medication use) at exam 5. CVH was determined with 7 health metrics. Endothelial function was measured with brachial artery flow-mediated dilation (FMD). Poisson regression was used to determine associations between CVH and erectile dysfunction across categories of CVH (low, moderate, and high).
   RESULTS
   Age and proportion of Black or Latino participants decreased while proportion of Chinese-American participants increased with higher CVH category. FMD was higher in men without erectile dysfunction and higher in men with high vs. low CVH. Erectile dysfunction prevalence was lower with better CVH; 58% in men with low CVH, 41% with moderate CVH, and 33% with high CVH (P < 0.001). CVH was associated with erectile dysfunction; prevalence ratio = 0.75 (95% confidence interval (CI) = 0.66, 0.84) with moderate CVH and 0.68 (95% CI = 0.49, 0.94) with high CVH (vs. men with low CVH) and 0.93 (95% CI = 0.91, 0.96) for every 1-point higher CVH score in a fully adjusted model, including FMD, age, education, depression score, use of antidepressant or beta-blocker medications, chronic disease, heavy drinking, and race.
   CONCLUSION
   CVH is associated with future erectile dysfunction, even after adjustment for baseline FMD. Maintaining high CVH may improve quality of life for men.
C1 [Lane-Cordova, Abbi D.; Kershaw, Kiarri; Liu, Kiang; Lloyd-Jones, Donald M.] Northwestern Univ, Feinberg Sch Med, Dept Prevent Med, Chicago, IL 60611 USA.
   [Herrington, David] Wake Forest Univ, Dept Integrat Physiol & Pharmacol, Winston Salem, NC 27109 USA.
C3 Northwestern University; Feinberg School of Medicine; Wake Forest
   University
RP Lane-Cordova, AD (corresponding author), Northwestern Univ, Feinberg Sch Med, Dept Prevent Med, Chicago, IL 60611 USA.
EM abbi.lane-cordova@northwestern.edu
RI Lloyd-Jones, Donald/C-5899-2009
OI Lloyd-Jones, Donald/0000-0003-0847-6110
FU National Heart, Lung, and Blood Institute [N01-HC-95159, N01-HC-95169];
   NCRR [UL1-RR-024156, UL1-RR-025005]; American Heart Association's
   Strategically Focused Research Network in Prevention
FX The research was supported by contracts N01-HC-95159 through
   N01-HC-95169 from the National Heart, Lung, and Blood Institute and by
   grants UL1-RR-024156 and UL1-RR-025005 from NCRR. The authors thank the
   other investigators, staff, and participants of the MESA study for their
   valuable contributions. A full list of participating MESA investigators
   and institutions can be found at
   http://www.mesa-nhlbi.org.DrLane-Cordova is supported by the American
   Heart Association's Strategically Focused Research Network in
   Prevention.
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NR 31
TC 22
Z9 25
U1 0
U2 2
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0895-7061
EI 1941-7225
J9 AM J HYPERTENS
JI Am. J. Hypertens.
PD AUG
PY 2017
VL 30
IS 8
BP 815
EP 821
DI 10.1093/ajh/hpx060
PG 7
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA FF5YP
UT WOS:000409078100013
PM 28430921
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Koo, BK
   Kim, SW
   Yi, KH
   Moon, MK
AF Koo, Bo Kyung
   Kim, Sang Wan
   Yi, Ka Hee
   Moon, Min Kyong
TI Low Economic Status Is Identified as an Emerging Risk Factor for
   Diabetes Mellitus in Korean Men Aged 30 to 59 Years in Korean National
   Health and Nutrition Examination Survey 2008 to 2010
SO DIABETES & METABOLISM JOURNAL
LA English
DT Article
DE Diabetes mellitus; Obesity; Economic status; Korea
ID IMPAIRED GLUCOSE-TOLERANCE; METABOLIC SYNDROME; SOCIOECONOMIC
   INEQUALITIES; SOUTHERN INDIA; PREVALENCE; POPULATION; MORTALITY; WOMEN;
   DEPRESSION; MENOPAUSE
AB Background: We compared the association between economic status and the prevalence of diabetes mellitus (DM) using large nationwide datasets covering the previous 10 years in Korea.
   Methods: We analyzed the association between economic status and DM using Korean National Health and Nutrition Examination Survey (KNHANES) data from 2001 to 2010 weighted to represent the Korean population between 30 and 59 years of age. The economic status of participants was classified into quartiles according to monthly family income with an equivalence scale.
   Results: In men, the prevalence of diabetes in the lowest income quartile (Q1) was significantly higher than that in the other quartiles in 2008 (age and body mass index-adjusted odds ratio [OR], 1.846; 95% confidence interval [CI], 1.126 to 3.027; P=0.015), 2009 (OR, 1.706; 95% CI, 1.094 to 2.661; P=0.019), and 2010 (OR, 1.560; 95% CI, 1.024 to 2.377; P=0.039) but not in 2001 or 2005. The data indicated that classification in the lowest economic status was an independent risk factor for diabetes even after adjusting for abdominal obesity, dyslipidemia, hypertension and education level in men of KNHANES 2008 to 2010. Although economic status was significantly associated with abdominal obesity, hypertriglyceridemia, and hypertension in women (P<0.001), there was no significant association between economic status and DM in women.
   Conclusion: Korean men between 30 and 59 years of age with the lowest economic status had a significantly higher prevalence of DM in 2008 to 2010 even after adjusting for other risk factors.
C1 [Koo, Bo Kyung; Kim, Sang Wan; Yi, Ka Hee; Moon, Min Kyong] Seoul Natl Univ, Coll Med, Dept Internal Med, Seoul 156707, South Korea.
   [Koo, Bo Kyung; Kim, Sang Wan; Yi, Ka Hee; Moon, Min Kyong] Seoul Natl Univ, Coll Med, Dept Internal Med, Boramae Med Ctr, 20 Boramae Ro 5 Gil, Seoul 156707, South Korea.
C3 Seoul National University (SNU); Seoul National University (SNU); Seoul
   National University Hospital
RP Moon, MK (corresponding author), Seoul Natl Univ, Coll Med, Dept Internal Med, Boramae Med Ctr, 20 Boramae Ro 5 Gil, Seoul 156707, South Korea.
EM mkmoon@snu.ac.kr
RI Moon, Min/AAE-7663-2020; Koo, Bo/ABB-7170-2020; Kim, Sang
   Wan/J-5399-2012
OI Moon, Min Kyong/0000-0002-5460-2846; Kim, Sang Wan/0000-0001-9561-9110
FU Korean Diabetes Association
FX This study was supported by a grant from the Korean Diabetes
   Association.
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   [Anonymous], 2000, AS PAC PERSP RED OB
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NR 44
TC 10
Z9 11
U1 0
U2 3
PU KOREAN DIABETES ASSOC
PI SEOUL
PA 1010 RENAISSANCE TOWER BLDG, 14 MANRIJAE-RO, MAPO-GUO, SEOUL, 121-706,
   SOUTH KOREA
SN 2233-6079
EI 2233-6087
J9 DIABETES METAB J
JI Diabetes Metab. J.
PD APR
PY 2015
VL 39
IS 2
BP 137
EP 146
DI 10.4093/dmj.2015.39.2.137
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA DA7RD
UT WOS:000368000900007
PM 25922808
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Rechardt, M
   Shiri, R
   Lindholm, H
   Karppinen, J
   Viikari-Juntura, E
AF Rechardt, Martti
   Shiri, Rahman
   Lindholm, Harri
   Karppinen, Jaro
   Viikari-Juntura, Eira
TI Associations of metabolic factors and adipokines with pain in incipient
   upper extremity soft tissue disorders: a cross-sectional study
SO BMJ OPEN
LA English
DT Article
ID MUSCULOSKELETAL DISORDERS; SHOULDER PAIN; RISK-FACTORS; POPULATION;
   INFLAMMATION; PREVALENCE; DEPRESSION; SYMPTOMS; VALIDITY
AB Objectives: Earlier studies have suggested associations between metabolic factors and musculoskeletal pain or disorders. We studied the associations of obesity, lipids, other features of the metabolic syndrome and adipokines (adiponectin, leptin, resistin, visfatin) with upper extremity pain in a clinical population with incipient upper extremity soft tissue disorders (UESTDs).
   Design: A cross-sectional study.
   Setting: Primary healthcare (occupational health service) with further examinations at a research institute.
   Participants: Patients (N=163, 86% were women) seeking medical advice in the occupational health service due to incipient upper extremity symptoms with symptom duration of <1 month were referred for consultation to the Finnish Institute of Occupational Health from Spring 2006 to Fall 2008. We included all actively working subjects meeting diagnostic criteria based on physical examination. We excluded subjects meeting predetermined conditions.
   Outcome measure: Pain intensity was assessed with visual analogue scale and dichotomised at the highest tertile (cut-point 60).
   Results: Obesity (adjusted OR for high waist circumference 2.9, 95% CI 1.1 to 7.3), high-density lipoprotein cholesterol (OR 3.9, 95% CI 1.4 to 10.1 for low level) and triglycerides (OR 2.6, 95% CI 1.0 to 6.8 for high level) were associated with pain intensity. Of four adipokines studied, only visfatin was associated with upper extremity pain (adjusted OR 1.4, 95% CI 1.0 to 2.1 for 1SD increase in level).
   Conclusions: Abdominal obesity and lipids may have an impact on pain intensity in UESTDs. They may intensify pain through proinflammatory pain-modifying molecular pathways or by causing soft tissue pathology and dysfunction of their supplying arteries. Of four adipokines studied only one (visfatin) was associated with pain intensity. In the future, further studies are required to better understand the relationship between metabolic factors and UESTDs.
C1 [Rechardt, Martti; Shiri, Rahman; Lindholm, Harri; Karppinen, Jaro] Finnish Inst Occupat Hlth, Ctr Expertise Hlth & Work Abil, Helsinki, Finland.
   [Rechardt, Martti; Shiri, Rahman; Viikari-Juntura, Eira] Finnish Inst Occupat Hlth, Disabil Prevent Ctr, Helsinki, Finland.
   [Karppinen, Jaro] Univ Oulu, Dept Phys & Rehabil Med, Inst Clin Med, Oulu, Finland.
   [Karppinen, Jaro] Med Res Ctr Oulu, Oulu, Finland.
C3 Finnish Institute of Occupational Health; Finnish Institute of
   Occupational Health; University of Oulu
RP Rechardt, M (corresponding author), Finnish Inst Occupat Hlth, Ctr Expertise Hlth & Work Abil, Helsinki, Finland.
EM martti.rechardt@ttl.fi
RI Viegi, Giovanni/K-2746-2016; Shiri, Rahman/ABB-1780-2021
OI Karppinen, Jaro/0000-0002-2158-6042; Shiri, Rahman/0000-0002-9312-3100
FU Finnish Academy [111061, 129362]; Finnish Work Environment Fund
   [300910]; Academy of Finland (AKA) [111061] Funding Source: Academy of
   Finland (AKA)
FX The Finnish Academy (project numbers 111061 and 129362) and the Finnish
   Work Environment Fund (project number 300910) granted the study.
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NR 38
TC 22
Z9 23
U1 0
U2 8
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2044-6055
J9 BMJ OPEN
JI BMJ Open
PY 2013
VL 3
IS 8
AR e003036
DI 10.1136/bmjopen-2013-003036
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 301VX
UT WOS:000330561300057
PM 23959751
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Pohrt, A
   Kendel, F
   Demuth, I
   Drewelies, J
   Nauman, T
   Behlouli, H
   Stadler, G
   Pilote, L
   Regitz-Zagrosek, V
   Gerstorf, D
AF Pohrt, Anne
   Kendel, Friederike
   Demuth, Ilja
   Drewelies, Johanna
   Nauman, Tauseef
   Behlouli, Hassan
   Stadler, Gertraud
   Pilote, Louise
   Regitz-Zagrosek, Vera
   Gerstorf, Denis
TI Differentiating Sex and Gender Among Older Men and Women
SO PSYCHOSOMATIC MEDICINE
LA English
DT Article
DE gender differences; sex differences; gender score; older population;
   BSRI = Bem Sex-Role Inventory; LVEF = left ventricular ejection
   fraction; PAQ = Personal Attributes Questionnaire
ID RISK-FACTORS; HEALTH; COGNITION; AGE
AB Objective This study aimed to paradigmatically show the development of a gender score that can be used as either an adjustment or a matching variable to separate the effects of gender versus biological sex in a sample of older adults. Methods Our sample comprised 1100 participants from the Berlin Aging Study II (52% women, mean [standard deviation] age = 75.6 [3.8] years). The gender score included a multitude of gender-related variables and was constructed via logistic regression. In models of health outcomes, it was used as an adjustment variable in regression analyses as well as a matching variable to match older men and women according to their gender. Results Matching by gender substantially reduced sample size to n = 340. Analyses (either adjusting for gender or matching men and women according to gender) revealed that female sex was independently associated with lower grip strength (B = -14.47, 95% confidence interval [CI] = -15.51 to -13.44), better cognitive performance (B = 3.47, 95% CI = 1.94 to 5.0), higher pulse wave velocity (B = 0.19, 95% CI = 0.06 to 0.31), lower body mass index (B = -0.97, 95% CI = -1.74 to -0.21), and lower rates of metabolic syndrome (odds ratio = 0.53, 95% CI = 0.37 to 0.77). In addition, both sex and gender were independently associated with cognitive performance and depression. Conclusions Calculating a gender score allows for the inclusion of a large number of variables, creating parsimonious models that are adaptable to different data sets and alternative gender definitions. Depending on the research question and the sample properties, the gender score can be used as either an adjustment or a matching variable.
C1 [Pohrt, Anne; Kendel, Friederike; Nauman, Tauseef; Stadler, Gertraud; Regitz-Zagrosek, Vera] Charite Univ Med Berlin, Gender Med, Augustenburger Pl 1, D-13353 Berlin, Germany.
   [Pohrt, Anne] Charite Univ Med Berlin, Inst Biometry & Clin Epidemiol, Berlin, Germany.
   [Demuth, Ilja] Charite Univ Med Berlin, Dept Endocrinol & Metab Dis Including Div Lipid M, Berlin, Germany.
   [Demuth, Ilja] Free Univ Berlin, Berlin, Germany.
   [Demuth, Ilja] Humboldt Univ, Berlin, Germany.
   [Demuth, Ilja] Charite Univ Med Berlin, Berlin Inst Hlth, BCRT Berlin Inst Hlth Ctr Regenerat Therapies, Berlin, Germany.
   [Drewelies, Johanna; Gerstorf, Denis] Humboldt Univ, Dept Psychol, Berlin, Germany.
   [Behlouli, Hassan; Pilote, Louise] McGill Univ, Hlth Ctr, Res Inst, Ctr Outcomes Res & Evaluat,Dept Med, Montreal, PQ, Canada.
   [Regitz-Zagrosek, Vera] Univ Zurich, Univ Hosp Zurich, Dept Cardiol, Zurich, Switzerland.
   [Stadler, Gertraud] Univ Aberdeen, Appl Hlth Sci, Aberdeen, Scotland.
C3 Berlin Institute of Health; Free University of Berlin; Humboldt
   University of Berlin; Charite Universitatsmedizin Berlin; Berlin
   Institute of Health; Free University of Berlin; Humboldt University of
   Berlin; Charite Universitatsmedizin Berlin; Berlin Institute of Health;
   Free University of Berlin; Humboldt University of Berlin; Charite
   Universitatsmedizin Berlin; Free University of Berlin; Humboldt
   University of Berlin; Berlin Institute of Health; Free University of
   Berlin; Humboldt University of Berlin; Charite Universitatsmedizin
   Berlin; Humboldt University of Berlin; McGill University; University of
   Zurich; University Zurich Hospital; University of Aberdeen
RP Kendel, F (corresponding author), Charite Univ Med Berlin, Gender Med, Augustenburger Pl 1, D-13353 Berlin, Germany.
EM friederike.kendel@charite.de
RI Kendel, Friederike/ACS-7935-2022; Demuth, Ilja/ABD-5352-2021; Drewelies,
   Johanna/HTN-1677-2023
OI Stadler, Gertraud/0000-0002-1935-8200; Kendel,
   Friederike/0000-0002-3726-0338; Drewelies, Johanna/0000-0002-3774-2169;
   Regitz-Zagrosek, Vera/0000-0002-3566-3467; Pohrt,
   Anne/0000-0001-6104-622X; Gerstorf, Denis/0000-0002-2133-9498
FU German Federal Ministry of Education and Research (Bundesministerium fur
   Bildung und Forschung) [01GL1716A, 01GL1716B]
FX The GendAge study research project (co-PIs are Ilja Demuth, Vera
   Regitz-Zagrosek, and Denis Gerstorf) is supported by the German Federal
   Ministry of Education and Research (Bundesministerium fur Bildung und
   Forschung; grant numbers 01GL1716A [I.D. and V.R.-Z.] and 01GL1716B
   [D.G.]). Additional contributions (e.g., equipment, logistics,
   personnel) are made from each of the participating sites. The study
   sponsors had no role in the design and conduct of the study. There are
   no conflicts of interest.
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NR 43
TC 5
Z9 5
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0033-3174
EI 1534-7796
J9 PSYCHOSOM MED
JI Psychosom. Med.
PD APR
PY 2022
VL 84
IS 3
BP 339
EP 346
DI 10.1097/PSY.0000000000001056
PG 8
WC Psychiatry; Psychology; Psychology, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry; Psychology
GA 0E6JG
UT WOS:000776785100014
PM 35149636
DA 2025-06-11
ER

PT J
AU Schistad, EI
   Stubhaug, A
   Furberg, AS
   Engdahl, BL
   Nielsen, CS
AF Schistad, Elina Iordanova
   Stubhaug, Audun
   Furberg, Anne-Sofie
   Engdahl, Bo Lars
   Nielsen, Christopher Sivert
TI C-reactive protein and cold-pressor tolerance in the general population:
   the Tromso Study
SO PAIN
LA English
DT Article
DE Pain sensitivity; Cold-pressor test; C-reactive protein; Inflammation;
   Chronic pain
ID PAIN-SENSITIVITY; CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME;
   RISK-FACTORS; INFLAMMATION; HEALTH; DEPRESSION; WOMEN; ASSOCIATION;
   MECHANISMS
AB The aim of this study was to examine whether increases in severity of subclinical inflammation, measured by high-sensitivity C-reactive protein (hs-CRP), increased experimental pain sensitivity, measured by cold-pressor tolerance, and to test whether this relationship is independent of chronic pain. A large population-based study from 2007 to 2008, the sixth Tromso Study, provided data from 12,981 participants. For the present analysis, complete data for 10,274 participants (age: median 58 years) were available. The main outcome measure was cold-pressor tolerance, tested by placing the dominant hand in circulating cold water (3 degrees C) for a maximum of 106 seconds. Cox proportional hazard models, treating hand withdrawal during the cold-pressor test as the event and enduring the full test time as censored data, were used to investigate the relationship between hs-CRP levels (<= 3 or >3 mg/L) and cold-pressure tolerance. The fully adjusted model was controlled for age, sex, education, body mass index, smoking status, alcohol consumption, emotional distress, statin usage, and self-reported presence of chronic pain. Additional analysis was performed in participants without chronic pain. Higher levels of hs-CRP were negatively related to cold-pressor tolerance (hazard ratio [HR] = 1.24, 95% confidence interval [CI], 1.12-1.37, P < 0.001), adjusted for age and sex. This relationship remained essentially unaltered after controlling for potential confounders (HR = 1.22, 95% CI, 1.09-1.36, P < 0.001), as well as for the presence of chronic pain (HR = 1.22, 95% CI, 1.09-1.36, P < 0.001). The present data show that subclinical inflammation is related to increased pain sensitivity, suggesting a potential role of inflammation in experimental pain which may be of importance for the development of clinical pain.
C1 [Schistad, Elina Iordanova] Oslo Univ Hosp, Dept Phys Med & Rehabil, Div Clin Neurosci, Oslo, Norway.
   [Schistad, Elina Iordanova; Stubhaug, Audun; Nielsen, Christopher Sivert] Oslo Univ Hosp, Dept Pain Management & Res, Div Emergencies & Intens Care, Oslo, Norway.
   [Stubhaug, Audun] Univ Oslo, Inst Clin Med, Oslo, Norway.
   [Furberg, Anne-Sofie] UiT Arctic Univ Norway, Fac Hlth Sci, Dept Community Med, Tromso, Norway.
   [Furberg, Anne-Sofie] Univ Hosp North Norway, Dept Microbiol & Infect Control, Tromso, Norway.
   [Engdahl, Bo Lars] Norwegian Inst Publ Hlth, Div Ageing & Hlth, Oslo, Norway.
C3 University of Oslo; University of Oslo; University of Oslo; UiT The
   Arctic University of Tromso; UiT The Arctic University of Tromso;
   University Hospital of North Norway; Norwegian Institute of Public
   Health (NIPH)
RP Schistad, EI (corresponding author), Oslo Univ Hosp HF, Dept Phys Med & Rehabil, Ulleval Box 4956, Oslo, Norway.
EM uxioel@ous-hs.no
RI Engdahl, Bo/IAP-9108-2023
OI Engdahl, Bo/0000-0002-9166-5782
FU South Eastern Norway Regional Health Authority [2015064]
FX This study was funded by financial support from the South Eastern Norway
   Regional Health Authority (Project no. 2015064). Special thanks are due
   to Dr. Cecilie Roe, Head of the Department for Physical Medicine and
   Rehabilitation, Oslo University Hospital and Professor at University of
   Oslo, for facilitating this research article and for manuscript editing.
   The authors are grateful to the study participants and the technical
   staff of the sixth Tromso Study for the valuable work.
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NR 62
TC 44
Z9 50
U1 1
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0304-3959
EI 1872-6623
J9 PAIN
JI Pain
PD JUL
PY 2017
VL 158
IS 7
BP 1280
EP 1288
DI 10.1097/j.pain.0000000000000912
PG 9
WC Anesthesiology; Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Anesthesiology; Neurosciences & Neurology
GA EZ8JS
UT WOS:000404972200014
PM 28420008
DA 2025-06-11
ER

PT J
AU Baghai, TC
   Varallo-Bedarida, G
   Born, C
   Häfner, S
   Schüle, C
   Eser, D
   Zill, P
   Manook, A
   Weigl, J
   Jooyandeh, S
   Nothdurfter, C
   von Schacky, C
   Bondy, B
   Rupprecht, R
AF Baghai, Thomas C.
   Varallo-Bedarida, Gabriella
   Born, Christoph
   Haefner, Sibylle
   Schuele, Cornelius
   Eser, Daniela
   Zill, Peter
   Manook, Andre
   Weigl, Johannes
   Jooyandeh, Somayeh
   Nothdurfter, Caroline
   von Schacky, Clemens
   Bondy, Brigitta
   Rupprecht, Rainer
TI Classical Risk Factors and Inflammatory Biomarkers: One of the Missing
   Biological Links between Cardiovascular Disease and Major Depressive
   Disorder
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE cardiovascular disease; cell adhesion molecules; immunology;
   inflammation; nervous system
ID C-REACTIVE PROTEIN; MYOCARDIAL-INFARCTION; SYMPTOMS; HEART;
   INTERLEUKIN-6; ATHEROSCLEROSIS; ASSOCIATION; CHOLESTEROL; MECHANISMS;
   MORTALITY
AB Background: Cardiovascular disorders (CVD) and major depressive disorder (MDD) are the most frequent diseases worldwide responsible for premature death and disability. Behavioral and immunological variables influence the pathophysiology of both disorders. We therefore determined frequency and severity of MDD in CVD and studied whether MDD without CVD or other somatic diseases influences classical and inflammatory biomarkers of cardiovascular risk. In addition, we investigated the influence of proinflammatory cytokines on antidepressant treatment outcome. Methods: In a case-control design, 310 adults (MDD patients without CVD, CVD patients, and cardiologically and psychiatrically healthy matched controls) were investigated. MDD patients were recruited after admission in a psychiatric university hospital. Primary outcome criteria were clinical depression ratings (HAM-D scale), vital signs, classical cardiovascular risk factors and inflammatory biomarkers which were compared between MDD patients and healthy controls. Results: We detected an enhanced cardiovascular risk in MDD. Untreated prehypertension and signs directing to a metabolic syndrome were detected in MDD. Significantly higher inflammatory biomarkers such as the high sensitivity C-reaktive protein (hsCRP) and proinflammatory acute phase cytokines interleukine-1 (IL-1) and interleukine-6 (IL-6) underlined the higher cardiovascular risk in physically healthy MDD patients. Surprisingly, high inflammation markers before treatment were associated with better clinical outcome and faster remission. The rate of MDD in CVD patients was high. Conclusions: Patients suffering from MDD are at specific risk for CVD. Precise detection of cardiovascular risks in MDD beyond classical risk factors is warranted to allow effective prophylaxis and treatment of both conditions. Future studies of prophylactic interventions may help to provide a basis for prophylactic treatment of both MDD and CVD. In addition, the high risk for MDD in CVD patients was confirmed and underlines the requirement for clinical attention.
C1 [Baghai, Thomas C.; Born, Christoph; Haefner, Sibylle; Schuele, Cornelius; Eser, Daniela; Zill, Peter; Bondy, Brigitta; Rupprecht, Rainer] Ludwig Maximilian Univ Munich, Dept Psychiat & Psychotherapy, Nussbaumstr 7, D-80336 Munich, Germany.
   [Baghai, Thomas C.; Manook, Andre; Weigl, Johannes; Jooyandeh, Somayeh; Nothdurfter, Caroline; Rupprecht, Rainer] Univ Regensburg, Dept Psychiat & Psychotherapy, Univ Str 84, D-93053 Regensburg, Germany.
   [Varallo-Bedarida, Gabriella; von Schacky, Clemens] Ludwig Maximilian Univ Munich, Dept Internal Med, Prevent Cardiol, Ziemssenstr 1, D-80336 Munich, Germany.
   [Rupprecht, Rainer] Max Planck Inst Psychiat, Kraepelinstr 2-10, D-80804 Munich, Germany.
C3 University of Munich; University of Regensburg; University of Munich;
   Max Planck Society
RP Baghai, TC (corresponding author), Ludwig Maximilian Univ Munich, Dept Psychiat & Psychotherapy, Nussbaumstr 7, D-80336 Munich, Germany.; Baghai, TC (corresponding author), Univ Regensburg, Dept Psychiat & Psychotherapy, Univ Str 84, D-93053 Regensburg, Germany.
EM Thomas.Baghai@medbo.de; Gabriella.Bedarida@pfizer.com;
   Christoph.Born@vivantes.de; sibylle.haefner@med.uni-heidelberg.de;
   Cornelius.Schuele@med.uni-muenchen.de; Daniela.Eser@med.uni-muenchen.de;
   Peter.Zill@med.uni-muenchen.de; Andre.Manook@medbo.de;
   Johannes.Weigl@medbo.de; Somayeh.MohammadiJooyandeh@medbo.de;
   Caroline.Nothdurfter@medbo.de; Clemens.vonSchacky@med.uni-muenchen.de;
   brigitta.bondy@med.uni-muenchen.de; Rainer.Rupprecht@medbo.de
OI Baghai, Thomas C/0000-0002-7873-4130; von Schacky,
   Clemens/0000-0001-6022-6624; Born MHBA, Dr.
   Christoph/0000-0003-0856-230X
FU Deutsche Forschungsgemeinschaft [DFG BA 2309/1-1]
FX This project is supported by a grant from the Deutsche
   Forschungsgemeinschaft (DFG BA 2309/1-1, funding period 2004-2008). The
   authors would like to thank Sylvia de Jonge and Klaus Neuner for expert
   technical assistance.
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NR 50
TC 44
Z9 49
U1 0
U2 10
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD JUN
PY 2018
VL 19
IS 6
AR 1740
DI 10.3390/ijms19061740
PG 12
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Biochemistry & Molecular Biology; Chemistry
GA GK8UZ
UT WOS:000436506600195
PM 29895759
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Galbete, C
   Contreras, R
   Martínez, JA
   Martínez-González, MA
   Guillén-Grima, F
   Marti, A
AF Galbete, Cecilia
   Contreras, Rafael
   Alfredo Martinez, J.
   Angel Martinez-Gonzalez, Miguel
   Guillen-Grima, Francisco
   Marti, Amelia
TI Physical Activity and Sex Modulate Obesity Risk Linked to 3111T/C Gene
   Variant of the CLOCK Gene in an Elderly Population: The SUN
   Project
SO CHRONOBIOLOGY INTERNATIONAL
LA English
DT Article
DE Aging; Body mass index; CLOCK; Cross-sectional study; Obesity risk;
   rs1801260
ID BODY-MASS INDEX; FTO RS9939609 POLYMORPHISM; CIRCADIAN CLOCK; RECEPTOR
   GENE; MEDITERRANEAN DIET; ENERGY-INTAKE; SEGUIMIENTO-UNIVERSIDAD;
   BIPOLAR DEPRESSION; METABOLIC SYNDROME; AFRICAN-AMERICAN
AB Genetic factors may interact with physical activity levels to modify obesity risk. Our aim was to explore the influence of rs1801260 single-nucleotide polymorphism (SNP) (3111T/C) of CLOCK gene on obesity risk, and to examine its potential interaction with lifestyle factors in an elderly population within the SUN ("Seguimiento Universidad de Navarra") Project. Subjects (n = 903, aged 69 +/- 6 yrs) were recruited from the SUN Project. DNA was obtained from saliva, whereas lifestyle and dietary data were collected by validated self-report questionnaires. Genotype was assessed by reverse transcriptase-polymerase chain reaction (RT-PCR) plus allele discrimination. A significant interaction was observed between the 3111T/C SNP of CLOCK gene and sex for overweight/obesity risk (p for sex x CLOCK interaction <.001). Our results showed that women carrying the C allele of CLOCK gene had a marginally significant lower risk of overweight/obesity compared with noncarrier-TT-subjects (odds ratio [OR]: .61, 95% confidence interval [CI]: .36-1.04; p=.069). Moreover, this association of the C allele with a decreased overweight/obesity risk might be enhanced in those women with a high physical activity level. Women practicing more than 16.8 metabolic equivalent tasks (hours per week) had a significantly lower overweight/obesity risk (OR: .36, 95% CI: .17-.79; p=.011). Furthermore, a significant interaction between the 3111T/C gene variant and physical activity (PA) for overweight/obesity risk was observed but only in women (p for PA x CLOCK interaction <.050). In conclusion, it appears that physical activity levels may act by modifying the association of the 3111T/C SNP (rs1801260) of the CLOCK gene with overweight/obesity risk in elderly women in the SUN Project.
C1 [Galbete, Cecilia; Contreras, Rafael; Alfredo Martinez, J.; Marti, Amelia] Univ Navarra, Dept Nutr Food Sci Physiol & Toxicol, Pamplona 31008, Navarra, Spain.
   [Angel Martinez-Gonzalez, Miguel] Univ Navarra, Dept Prevent Med & Publ Hlth, Pamplona 31008, Navarra, Spain.
   [Guillen-Grima, Francisco] Univ Navarra Clin, Div Prevent Med, Pamplona, Spain.
C3 University of Navarra; University of Navarra; University of Navarra
RP Marti, A (corresponding author), Univ Navarra, Dept Nutr Food Sci Physiol & Toxicol, C Irunlarrea S-N, Pamplona 31008, Navarra, Spain.
EM amarti@unav.es
RI Martínez-González, Marina/R-6165-2016; Martinez-Gonzalez,
   Miguel/AAE-7669-2019; Guillen-Grima, FRANCISCO/H-3359-2012; Marti del
   Moral, Amelia/H-1192-2017; Martinez Hernandez, J Alfredo/K-8709-2014;
   Galbete, Cecilia/M-1276-2013
OI Guillen-Grima, FRANCISCO/0000-0001-9749-8076; Martinez-Gonzalez, Miguel
   A./0000-0002-3917-9808; Marti del Moral, Amelia/0000-0001-9832-7981;
   Martinez Hernandez, J Alfredo/0000-0001-5218-6941; Galbete,
   Cecilia/0000-0002-2497-6791
FU Spanish Government [PI01/0619, PI030678, PI040233, PI042241, PI050976,
   PI070240, PI070312, PI081943, PI080819, PI1002658, PI1002293, RD06/0045,
   G03/140, 87/2010]; Navarra Regional Government [36/2001, 43/2002,
   41/2005, 36/2008]; University of Navarra, Linea Especial, Nutricion y
   Obesidad (University of Navarra); Carlos III Health Institute (CIBER
   project) [CB06/03/1017]; RETICS network; Asociacion de Amigos de la
   Universidad de Navarra
FX The SUN Study has received funding from the Spanish Government (grants
   PI01/0619, PI030678, PI040233, PI042241, PI050976, PI070240, PI070312,
   PI081943, PI080819, PI1002658, PI1002293, RD06/0045, G03/140, and
   87/2010), the Navarra Regional Government (36/2001, 43/2002, 41/2005,
   36/2008), and the University of Navarra, Linea Especial, Nutricion y
   Obesidad (University of Navarra), Carlos III Health Institute (CIBER
   project, CB06/03/1017), and RETICS network. The scholarship to C.
   Galbete from the Asociacion de Amigos de la Universidad de Navarra is
   fully acknowledged.
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NR 58
TC 28
Z9 28
U1 0
U2 11
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 0742-0528
EI 1525-6073
J9 CHRONOBIOL INT
JI Chronobiol. Int.
PY 2012
VL 29
IS 10
BP 1397
EP 1404
DI 10.3109/07420528.2012.728657
PG 8
WC Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics; Physiology
GA 047JU
UT WOS:000311837200013
PM 23131019
DA 2025-06-11
ER

PT J
AU McMurray, RG
   Zaldivar, F
   Galassetti, P
   Larson, J
   Eliakim, A
   Temet, D
   Cooper, DM
AF McMurray, Robert G.
   Zaldivar, Frank
   Galassetti, Pietro
   Larson, Jennifer
   Eliakim, Alon
   Temet, Dan
   Cooper, Dan M.
TI Cellular immunity and inflammatory mediator responses to intense
   exercise in overweight children and adolescents
SO JOURNAL OF INVESTIGATIVE MEDICINE
LA English
DT Article
DE pediatric obesity; proinflammatory cytokines; leukocytes; physical
   activity; immune responses; cytokines
ID C-REACTIVE PROTEIN; MUSCLE-DERIVED INTERLEUKIN-6; TNF-ALPHA;
   IMMUNOLOGICAL CHANGES; STRENUOUS EXERCISE; METABOLIC SYNDROME;
   ADIPOSE-TISSUE; INSULIN ACTION; OBESITY; CYTOKINES
AB Background: Obesity modifies inflammatory mediators, but little is known about how obesity modifies the inflammatory responses of exercising children. This study assessed the acute effect of exercise on inflammatory mediators in overweight children.
   Methods: Twenty-eight overweight (OW) youth (body mass index > 85%) and 30 normal-weight (NW) controls of the same proportions of age and gender performed 10 2-minute bouts of cycle ergometry exercise above the anaerobic threshold, with 1-minute rest intervals between bouts. Pre- and postexercise blood samples were collected for white blood cell subpopulation and inflammatory cytokines.
   Results: Baseline leukocyte populations were higher in OW youth (p < .05). Exercise increased most leukocyte subtypes for both groups (p < .05). Granulocytes remained elevated 2 hours postexercise (p < .05) for both groups, whereas monocytes remained elevated 2 hours postexercise for the OW children. Natural killer (NK) cells dropped below baseline 2 hours postexercise. Exercise significantly decreased CD4 and CD8 cells, which remained depressed 2 hours postexercise in the OW children. Baseline levels of interleukin (IL)-6 were approximate to 64% higher in OW children (p < .001). Exercise increased IL-6 in both groups (p < .001), which further increased 2 hours postexercise (p < .05). Tumor necrosis factor alpha, IL-1 beta, and IL-1 receptor antagonist did not change with exercise.
   Conclusions: Elevated baseline leukocyte subtypes and IL-6 levels in OW children suggest that childhood obesity is associated with a chronic low-grade inflammatory state. The acute inflammatory response to intense exercise appears to be similar between NW and OW children for most markers, but the depression of NK, CD4, and CD8 cells 2 hours postexercise suggests that an acute risk of mitogen-induced inflammation may exist in OW children after high-intensity exercise.
C1 Univ Calif Irvine, Dept Pediat, Univ Childrens Hosp, Irvine, CA 92717 USA.
   Univ N Carolina, Dept Exercise & Sport Sci, Chapel Hill, NC USA.
   Tel Aviv Univ, Sackler Sch Med, Meir Med Ctr, IL-69978 Tel Aviv, Israel.
C3 University of California System; University of California Irvine;
   University of North Carolina; University of North Carolina Chapel Hill;
   Tel Aviv University; Sackler Faculty of Medicine
RP Galassetti, P (corresponding author), UCI GCRC, Bionutr Metab Core, 101 City Dr,Bldg 25,2nd Floor, Orange, CA 92868 USA.
EM pgalasse@uci.edu
RI Cooper, Dan/AAA-6699-2022
FU NCRR NIH HHS [M01RR00827-S1] Funding Source: Medline; NICHD NIH HHS
   [P01HD-048721, R01 HD26939-14] Funding Source: Medline
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NR 44
TC 24
Z9 32
U1 0
U2 12
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 1081-5589
EI 1708-8267
J9 J INVEST MED
JI J. Invest. Med.
PD APR
PY 2007
VL 55
IS 3
BP 120
EP 129
DI 10.2310/6650.2007.06031
PG 10
WC Medicine, General & Internal; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Research & Experimental Medicine
GA 221OU
UT WOS:000250238000015
PM 17481381
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Ahnis, A
   Figura, A
   Hofmann, T
   Stengel, A
   Elbelt, U
   Klapp, BF
AF Ahnis, Anne
   Figura, Andrea
   Hofmann, Tobias
   Stengel, Andreas
   Elbelt, Ulf
   Klapp, Burghard F.
TI Surgically and Conservatively Treated Obese Patients Differ in
   Psychological Factors, Regardless of Body Mass Index or Obesity-Related
   Co-Morbidities: A Comparison between Groups and an Analysis of
   Predictors
SO PLOS ONE
LA English
DT Article
ID QUALITY-OF-LIFE; ICD-10-SYMPTOM-RATING ISR; METABOLIC SYNDROME;
   BARIATRIC SURGERY; FOLLOW-UP; QUESTIONNAIRE; VALIDATION; DEPRESSION;
   IMPACT; RISK
AB Objective
   For the treatment of obesity, both conservative and surgical procedures are available. Psychological factors are likely to influence the choice of treatment; however, to date, systematic studies that investigate these factors are few in number. The aim of our study was to analyze whether patients who undergo a surgical treatment differ from those who require a conservative treatment in regard to psychological factors, regardless of their somatic conditions. Furthermore, predictors of treatment choice will be examined.
   Methods
   A total of 244 patients (189 women), with a mean body mass index of 45.1 kg/m(2), underwent a weight reduction treatment, with 126 patients undergoing bariatric surgery and 118 patients participating in a conservative, multimodal outpatient weight reduction program. Differences in the results of the psychological questionnaires between conservatively and surgically treated patients were evaluated through the use of t-tests, chi(2)-tests and an ANCOVA. For the analysis of the predictors, logistic regression models were calculated.
   Results
   Surgically and conservatively treated obese patients differ in psychological, somatic, and socio-demographic factors. The psychological differences between the groups are independent of obesity-related co-morbidities, such as body mass index (BMI), type 2 diabetes mellitus, hypertension and coronary heart disease. The following psychological and somatic factors equally predict the choice of bariatric surgery: apathy, delegated active coping, a sense of coherence, complaints, type 2 diabetes mellitus, BMI, and age.
   Conclusion
   Longitudinal studies are required to assess the predictive value of the psychological factors in regard to the postsurgical weight course to improve the pre-surgical screening and treatment selection process. The pre-surgical identification of psychological predictors should result in a more personalized medicine course and may ensure long term outcomes.
C1 [Ahnis, Anne; Figura, Andrea; Hofmann, Tobias; Stengel, Andreas; Klapp, Burghard F.] Charite, Ctr Internal Med & Dermatol, Div Gen Internal & Psychosomat Med, D-13353 Berlin, Germany.
   [Elbelt, Ulf] Charite, Ctr Internal Med Gastroenterol & Nephrol, Div Endocrinol Diabet & Nutr, D-13353 Berlin, Germany.
C3 Berlin Institute of Health; Free University of Berlin; Humboldt
   University of Berlin; Charite Universitatsmedizin Berlin; Berlin
   Institute of Health; Free University of Berlin; Humboldt University of
   Berlin; Charite Universitatsmedizin Berlin
RP Ahnis, A (corresponding author), Charite, Ctr Internal Med & Dermatol, Div Gen Internal & Psychosomat Med, D-13353 Berlin, Germany.
EM anne.ahnis@charite.de
RI Elbelt, Ulf/AAJ-6469-2020
OI Stengel, Andreas/0000-0003-3294-4340; Hofmann,
   Tobias/0000-0002-4002-3552; Figura, Andrea/0000-0002-1240-1501; Elbelt,
   Ulf/0000-0002-7510-9284
CR Ahnis A, 2010, DGPM DKPM K 2010 BER, V5, P210
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NR 36
TC 10
Z9 11
U1 0
U2 15
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD FEB 13
PY 2015
VL 10
IS 2
AR e0117460
DI 10.1371/journal.pone.0117460
PG 15
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Science & Technology - Other Topics
GA CC9IO
UT WOS:000350682600065
PM 25679521
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Beydoun, MA
   Nalls, MA
   Canas, JA
   Evans, MK
   Zonderman, AB
AF Beydoun, May A.
   Nalls, Michael A.
   Canas, J. Atilio
   Evans, Michele K.
   Zonderman, Alan B.
TI Gene polymorphisms and gene scores linked to low serum carotenoid status
   and their associations with metabolic disturbance and depressive
   symptoms in African-American adults
SO BRITISH JOURNAL OF NUTRITION
LA English
DT Article
DE Gene polymorphisms; Gene risk scores; Carotenoids; Metabolic
   disturbance; Depressive symptoms
ID DENSITY-LIPOPROTEIN CHOLESTEROL; NUTRITION EXAMINATION SURVEY; 3RD
   NATIONAL-HEALTH; SINGLE NUCLEOTIDE POLYMORPHISMS; MULTILOCUS GENOTYPE
   DATA; DIABETES-MELLITUS; APO-B-516C/T POLYMORPHISM; US ADULTS;
   ANTIOXIDANT CONCENTRATIONS; CARDIOVASCULAR-DISEASE
AB Gene polymorphisms provide a means to obtain unconfounded associations between carotenoids and various health outcomes. In the present study, we tested whether gene polymorphisms and gene scores linked to low serum carotenoid status are related to metabolic disturbance and depressive symptoms in African-American adults residing in Baltimore city, MD, using cross-sectional data from the Healthy Aging in Neighborhoods of Diversity across the Life Span study (age range 30-64 years, n 873-994). We examined twenty-four SNP of various gene loci that were previously shown to be associated with low serum carotenoid status (SNPlcar). Gene risk scores were created: five low specific-carotenoid risk scores (LSCRS: alpha-carotene, beta-carotene, lutein+zeaxanthin, beta-cryptoxanthin and lycopene) and one low total-carotenoid risk score (LTCRS: total carotenoids). SNPlcar, LSCRS and LTCRS were entered as predictors for a number of health outcomes. These included obesity, National Cholesterol Education Program Adult Treatment Panel III metabolic syndrome and its components, elevated homeostatic model assessment of insulin resistance, C-reactive protein, hyperuricaemia and elevated depressive symptoms (EDS, Center for Epidemiologic Studies-Depression score >= 16). Among the key findings, SNPlcar were not associated with the main outcomes after correction for multiple testing. However, an inverse association was found between the LTCRS and HDL-cholesterol (HDL-C) dyslipidaemia. Specifically, the alpha-carotene and beta-cryptoxanthin LSCRS were associated with a lower odds of HDL-C dyslipidaemia. However, the beta-cryptoxanthin LSCRS was linked to a higher odds of EDS, with a linear dose-response relationship. In summary, gene risk scores linked to low serum carotenoids had mixed effects on HDL-C dyslipidaemia and EDS. Further studies using larger African-American population samples are needed.
C1 [Beydoun, May A.; Evans, Michele K.; Zonderman, Alan B.] NIA, Lab Epidemiol & Populat Sci, NIH, Biomed Res Ctr, Baltimore, MD 21224 USA.
   [Nalls, Michael A.] NIA, Neurogenet Lab, NIH, Baltimore, MD 21224 USA.
   [Canas, J. Atilio] Nemours Childrens Clin, Jacksonville, FL USA.
C3 National Institutes of Health (NIH) - USA; NIH National Institute on
   Aging (NIA); National Institutes of Health (NIH) - USA; NIH National
   Institute on Aging (NIA)
RP Beydoun, MA (corresponding author), NIA, Lab Epidemiol & Populat Sci, NIH, Biomed Res Ctr, IRP 251,Bayview Blvd,Suite 100,Room 04B118, Baltimore, MD 21224 USA.
EM baydounm@mail.nih.gov
RI Canas, Jose/Y-8500-2019; Zonderman, Alan/A-5807-2013; Evans,
   Michele/AAE-4776-2019; Weale, Michael/F-2587-2010; Canas,
   Jose/F-3193-2017
OI Evans, Michele/0000-0002-8546-2831; Canas, Jose/0000-0003-4788-8820;
   Zonderman, Alan B/0000-0002-6523-4778
FU Intramural Research Program of the NIH, National Institute on Aging
FX The present study was fully supported by the Intramural Research Program
   of the NIH, National Institute on Aging.
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U1 0
U2 10
PU CAMBRIDGE UNIV PRESS
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PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1145
EI 1475-2662
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PD SEP 28
PY 2014
VL 112
IS 6
BP 992
EP 1003
DI 10.1017/S0007114514001706
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA AP3JD
UT WOS:000341970800016
PM 25201307
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Shen, QH
   Bergquist-Beringer, S
   Sousa, VD
AF Shen, Qiuhua
   Bergquist-Beringer, Sandra
   Sousa, Valmi D.
TI Major Depressive Disorder and Insulin Resistance in Nondiabetic Young
   Adults in the United States: The National Health and Nutrition
   Examination Survey, 1999-2002
SO BIOLOGICAL RESEARCH FOR NURSING
LA English
DT Article
DE major depressive disorder; insulin resistance; gender; young adults;
   risk factors for type 2 diabetes
ID HOMEOSTASIS MODEL ASSESSMENT; INTERNATIONAL DIAGNOSTIC INTERVIEW;
   GLUCOSE CLAMP TECHNIQUE; METABOLIC SYNDROME; SYMPTOMS; RISK; PREVALENCE;
   POPULATION; DISEASES; COHORT
AB Objective: The association between depression and insulin resistance has been evaluated in previous studies with conflicting results. This study aimed to explore the relationship between major depressive disorder (MDD) and insulin resistance among nondiabetic young adult men and women in the United States. Method: Analyses of cross-sectional data from the National Health and Nutrition Examination Survey (NHANES), 1999-2002, were conducted. The nationally representative sample consisted of 279 men and 358 women aged 20-39 years. MDD was determined by the WHO Composite International Diagnostic Interview (CIDI). Insulin resistance was measured by the homeostasis model assessment for insulin resistance. Results: Of 637 subjects, 16 men and 18 women had MDD (weighted percentage = 6.6%, SE = 1.2). Using logistic regression, no significant association was found between MDD and insulin resistance among the nondiabetic young adults in bivariate analysis (beta = -0.01, OR = 0.99, 95% CI = [0.38, 2.57], p = .98). A significant interaction effect between gender and MDD was observed. For men, MDD was negatively associated with insulin resistance after adjusting for age, race/ethnicity, waist circumference, smoking status, systolic blood pressure and triglyceride level (beta = -2.12, OR = 0.12, 95% CI = [0.02, 0.62], p = .01). No significant association between MDD and insulin resistance among women was found (beta = 0.61, OR = 1.84, 95% CI = [0.47, 7.14], p = .38). Conclusions: Overall findings suggest there is no significant association between MDD and insulin resistance among nondiabetic young adults aged 20-39 years. However, gender differences in this relationship were noted.
C1 [Shen, Qiuhua; Bergquist-Beringer, Sandra; Sousa, Valmi D.] Univ Kansas, Med Ctr, Sch Nursing, Kansas City, KS 66160 USA.
C3 University of Kansas; University of Kansas Medical Center
RP Shen, QH (corresponding author), Univ Kansas, Med Ctr, Sch Nursing, 3901 Rainbow Blvd, Kansas City, KS 66160 USA.
EM qshen@kumc.edu
OI Shen, Qiuhua/0000-0002-1236-0244
CR Adriaanse MC, 2006, DIABETOLOGIA, V49, P2874, DOI 10.1007/s00125-006-0500-4
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NR 32
TC 12
Z9 13
U1 0
U2 6
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1099-8004
J9 BIOL RES NURS
JI Biol. Res. Nurs.
PD APR
PY 2011
VL 13
IS 2
BP 175
EP 181
DI 10.1177/1099800410384501
PG 7
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nursing
GA 735ZP
UT WOS:000288459600007
PM 21044969
DA 2025-06-11
ER

PT J
AU O'Connor, DB
   Corona, G
   Forti, G
   Tajar, A
   Lee, DM
   Finn, JD
   Bartfai, G
   Boonen, S
   Casanueva, FF
   Giwercman, A
   Huhtaniemi, IT
   Kula, K
   O'Neill, TW
   Pendleton, N
   Punab, M
   Silman, AJ
   Vanderschueren, D
   Wu, FCW
AF O'Connor, Daryl B.
   Corona, Giovanni
   Forti, Gianni
   Tajar, Abdelouahid
   Lee, David M.
   Finn, Joseph D.
   Bartfai, Gyorgy
   Boonen, Steven
   Casanueva, Felipe F.
   Giwercman, Aleksander
   Huhtaniemi, Ilpo T.
   Kula, Krzysztof
   O'Neill, Terence W.
   Pendleton, Neil
   Punab, Margus
   Silman, Alan J.
   Vanderschueren, Dirk
   Wu, Frederick C. W.
CA European Male Ageing Study Grp
TI Assessment of sexual health in aging men in Europe: Development and
   validation of the European Male Ageing Study sexual function
   questionnaire
SO JOURNAL OF SEXUAL MEDICINE
LA English
DT Article
DE male sexual function; middle-aged and elderly men; aging; testosterone
ID QUALITY-OF-LIFE; ERECTILE DYSFUNCTION; STRUCTURED INTERVIEW; METABOLIC
   SYNDROME; TESTOSTERONE; POPULATION; SCALE; HYPOGONADISM; PREVALENCE
AB Introduction. Assessment of male sexual dysfunction has been the focus of substantial scientific effort. Less research has focused on the development of instruments for the measurement of sexual functioning in aging men.
   Aim. The aims of this study were: (i) to characterize the psychometric properties of a new brief, reliable, and valid measure of male sexual functioning for use in a large population survey of middle-aged and elderly European men; and (ii) specifically, to determine whether the new instrument, the European Male Ageing Study-sexual function questionnaire (EMAS-SFQ), discriminates between men with high and low levels of circulating testosterone (T) (total T, free T, and bioavailable T).
   Method. One thousand six hundred men aged 40-79 years completed the self-administered EMAS-SFQ, the Beck depression inventory, and provided a blood sample for assessment of sex hormones. Eighty-five men aged 35-74 years completed the EMAS-SFQ twice, 2 weeks apart to examine the test-retest reliability of the instrument.
   Main Outcome Measures. Scores on the EMAS-SFQ in relation to age and T levels.
   Results. Principal component analysis showed that the EMAS-SFQ had four distinct domains (overall sexual functioning [OSF], masturbation, sexual functioning-related distress, and change in sexual functioning). The instrument demonstrated excellent internal and test-retest reliability, as well as convergent, divergent, and discriminant validity. Men with the lowest levels of total, free, and bioavailable T reported lower OSF scores compared to men with the highest T levels.
   Conclusion. The EMAS-SFQ is a valid and reproducible instrument, sensitive to age and T levels. It should be suitable for the assessment of sexual health in population samples of men in epidemiological studies of aging.
C1 [O'Connor, Daryl B.] Univ Leeds, Inst Psychol Sci, Leeds, W Yorkshire, England.
   [Forti, Gianni] Univ Florence, Dept Clin Physiopathol, Androl Unit, Florence, Italy.
   [Tajar, Abdelouahid; Lee, David M.; Finn, Joseph D.; O'Neill, Terence W.; Silman, Alan J.] Univ Manchester, ARC Epidemiol Unit, Manchester, Lancs, England.
   [Bartfai, Gyorgy] Albert Szent Gyorgyi Med Univ, Dept Obstet Gynaecol & Androl, H-6701 Szeged, Hungary.
   [Boonen, Steven; Vanderschueren, Dirk] Katholieke Univ Leuven, Dept Geriatr Med, Louvain, Belgium.
   [Casanueva, Felipe F.] Univ Santiago de Compostela, Dept Med, Santiago De Compostela, Spain.
   [Giwercman, Aleksander] Lund Univ, Scanian Androl Ctr, Malmo Univ Hosp, Dept Urol, Lund, Sweden.
   [Huhtaniemi, Ilpo T.] Univ London Imperial Coll Sci Technol & Med, Dept Reprod Biol, London, England.
   [Kula, Krzysztof] Med Univ Lodz, Dept Androl & Reprod Endocrinol, Lodz, Poland.
   [Pendleton, Neil] Univ Manchester, Dept Geriatr Med, Manchester, Lancs, England.
   [Punab, Margus] Tartu Univ Hosp, Androl Unit, Tartu, Estonia.
   [Wu, Frederick C. W.] Univ Manchester, Dept Endocrinol, Manchester Royal Infirm, Manchester, Lancs, England.
   [Corona, Giovanni; Forti, Gianni] Univ Florence, Dept Clin Physiopathol, Androl Unit, Florence, Italy.
C3 University of Leeds; University of Florence; University of Manchester;
   Szeged University; KU Leuven; Universidade de Santiago de Compostela;
   Lund University; Skane University Hospital; Imperial College London;
   Medical University Lodz; University of Manchester; University of
   Manchester; University of Florence
RP O'Connor, DB (corresponding author), Univ Leeds, Inst Psychol Sci, Leeds, W Yorkshire, England.
EM d.b.o'connor@leeds.ac.uk
RI Woo, Jean/K-2625-2014; giovannelli, jonathan/I-5307-2018; Tajar,
   Abdelouahid/A-3782-2010; , Margus Punab/KXS-1159-2024; Kujala,
   Urho/AAP-2547-2020; Pendleton, Neil/F-2333-2015; Lee, David/D-1005-2009;
   Pye, Stephen/D-9236-2011
OI O'Neill, Terence/0000-0002-8896-4677; Pendleton,
   Neil/0000-0003-0794-2386; Punab, Margus/0000-0001-9601-6311; Han,
   Thang/0000-0003-2570-0938; Lee, David/0000-0003-3472-0789; Pye,
   Stephen/0000-0002-7263-2897; vanderschueren, dirk/0000-0003-1395-0104;
   O'Connor, Daryl/0000-0003-4117-4093
CR Araujo AB, 2000, AM J EPIDEMIOL, V152, P533, DOI 10.1093/aje/152.6.533
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NR 33
TC 80
Z9 82
U1 0
U2 10
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1743-6095
EI 1743-6109
J9 J SEX MED
JI J. Sex. Med.
PD JUN
PY 2008
VL 5
IS 6
BP 1374
EP 1385
DI 10.1111/j.1743-6109.2008.00781.x
PG 12
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Urology & Nephrology
GA 308TB
UT WOS:000256411800012
PM 18331267
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Larsen, JI
   Andersen, UA
   Becker, T
   Bickel, GG
   Borks, B
   Cordes, J
   Frasch, K
   Jacobsen, BA
   Jensen, SOW
   Kilian, R
   Lauber, C
   Mogensen, B
   Nielsen, JA
   Rössler, W
   Tsuchiya, KJ
   Uwakwe, R
   Munk-Jorgensen, P
AF Larsen, Jens I.
   Andersen, Ulla A.
   Becker, Thomas
   Bickel, Graziella G.
   Borks, Bernhard
   Cordes, Joachim
   Frasch, Karel
   Jacobsen, Bent A.
   Jensen, Signe O. Wallenstein
   Kilian, Reinhold
   Lauber, Christoph
   Mogensen, Birthe
   Nielsen, Jorgen A.
   Roessler, Wulf
   Tsuchiya, Kenji J.
   Uwakwe, Richard
   Munk-Jorgensen, Povl
TI Cultural diversity in physical diseases among patients with mental
   illnesses
SO AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
LA English
DT Article
DE Cardiovascular disease; diabetes; mood disorders; obesity; physical
   health; schizophrenia; transcultural psychiatry
ID CORONARY-HEART-DISEASE; MEDICAL COMORBIDITY; METABOLIC SYNDROME;
   SCHIZOPHRENIA; MORTALITY; RISK; DISORDER; PEOPLE
AB Objective: People with psychiatric diseases have a severely increased risk for physical morbidity and premature death from physical diseases. The aims of the study were to investigate the occurrence of cardiovascular diseases (CVD), diabetes (DM) and obesity in schizophrenia and depression in three different geographical areas - Asia (Japan), Africa (Nigeria) and Western Europe (Switzerland, Germany and Denmark) - and to search for possible transcultural differences in these correlations, which would also reflect the differences between low-income areas in Africa (Nigeria) and high-income areas in Europe and Japan.
   Method: Patients with International Classification of Diseases (ICD-10) F2 diseases (schizophrenia spectrum disorders) and F3 diseases (affective disorders) admitted to one Nigerian, one Japanese, two Swiss, two German and six Danish centres during I year were included. Physical diseases in accordance with ICD-10 were also registered. Psychiatric and physical comorbidity were calculated and standardized rate ratio incidences of background populations were our primary measures.
   Results: Incidence rate ratios were increased for both CVD, DM and overweight in both F2 and F3 in all cultures (Western Europe, Nigeria and Japan) within the same ranges (however, the Japanese results should be interpreted conservatively owing to the limited sample size). Overweight among the mentally ill were marked in Nigeria. A parallelism of the incidence of overweight, CVD and diabetes with the occurrence in background populations was seen and was most marked in overweight.
   Conclusions: Overweight, CVD and DM were increased in schizophrenia spectrum disorders and affective disorders in all three cultures investigated (Western Europe, Nigeria and Japan). Lifestyle diseases were also seen in Nigeria and Japan. The results from this study indicate that cultural background might be seen as an important factor in dealing with lifestyle diseases among people with a severe mental illness, as it is in the general population.
C1 [Larsen, Jens I.; Jensen, Signe O. Wallenstein] Aarhus Univ Hosp, Aalborg Psychiat Hosp, Aarhus, Denmark.
   [Andersen, Ulla A.] Odense Univ Hosp, Odense, Denmark.
   [Becker, Thomas; Frasch, Karel; Kilian, Reinhold] Gunzburg Ulm Univ Hosp, Ulm, Germany.
   [Bickel, Graziella G.] Hosp Psychiat, Kantonale Marsens Fribou, Switzerland.
   [Borks, Bernhard] Hosp Psychiat, Augustenborg Tonder, Denmark.
   [Cordes, Joachim] Univ Dusseldorf, Dept Psychiat & Psychotherapy, Fac Med, Dusseldorf, Germany.
   [Jacobsen, Bent A.] Aarhus Univ Hosp, Aalborg Hosp, Aarhus, Denmark.
   [Lauber, Christoph; Roessler, Wulf] Psychiat Univ Hosp, Zurich, Switzerland.
   [Nielsen, Jorgen A.] Aarhus Univ Hosp, Skanderborg Odder, Denmark.
   [Tsuchiya, Kenji J.] Hamamatsu Sch Med, Res Ctr Child Mental Dev, Hamamatsu, Shizuoka, Japan.
   [Uwakwe, Richard] Nnamdi Azikiwe Univ, Fac Med, Nnewi, Nigeria.
   [Munk-Jorgensen, Povl] Aarhus Univ Hosp, Dept M, DK-8240 Risskov, Denmark.
C3 Aarhus University; Aarhus Psychiatric Hospital; University of Southern
   Denmark; Odense University Hospital; Heinrich Heine University
   Dusseldorf; Aarhus University; Aalborg University; Aalborg University
   Hospital; Aarhus University; Hamamatsu University School of Medicine;
   Aarhus University
RP Munk-Jorgensen, P (corresponding author), Aarhus Univ Hosp, Dept M, Skovagervej 2, DK-8240 Risskov, Denmark.
EM povmun@rm.dk
RI Rössler, Wolfgang/E-9526-2019; Becker, Thomas/O-9769-2014; Tsuchiya,
   Kenji/I-9123-2019
OI Tsuchiya, Kenji/0000-0002-1314-4199; Rossler, Wulf/0000-0003-0049-4533
FU Eli Lilly
FX Eli Lilly supported the planning meeting held in Aalborg, Denmark.
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NR 32
TC 11
Z9 11
U1 0
U2 29
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0004-8674
EI 1440-1614
J9 AUST NZ J PSYCHIAT
JI Aust. N. Z. J. Psych.
PD MAR
PY 2013
VL 47
IS 3
BP 250
EP 258
DI 10.1177/0004867412463614
PG 9
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 108OR
UT WOS:000316305800010
PM 23076547
DA 2025-06-11
ER

PT J
AU Krieg, A
   Krieg, S
   Heuser, A
   Laverenz, U
   Istrate, VA
   Schott, M
   Kostev, K
AF Krieg, Andreas
   Krieg, Sarah
   Heuser, Andreas
   Laverenz, Ulrich
   Istrate, Valentin-Alin
   Schott, Matthias
   Kostev, Karel
TI Exploring the Spectrum of Comorbidities Associated with Primary
   Aldosteronism: Insights from a Large Real-World Case-Control Study
SO BIOMEDICINES
LA English
DT Article
DE Conn syndrome; primary aldosteronism; adrenal gland; hypertension;
   hypokalemia; hepatic steatosis; gout; chronic kidney disease; diabetes
   mellitus
ID RESISTANT HYPERTENSION; PRIMARY HYPERALDOSTERONISM; METABOLIC SYNDROME;
   DIABETES-MELLITUS; BLOOD-PRESSURE; UNITED-STATES; PREVALENCE; DIAGNOSIS;
   ADRENALECTOMY; MANAGEMENT
AB Background: Primary aldosteronism (PA) is a common cause of endocrine hypertension, characterized by excessive aldosterone secretion leading to hypertension, hypokalemia, and metabolic alkalosis. While historically diagnosed based on this classic triad of symptoms, current understanding reveals a more nuanced presentation. This study aimed to investigate the prevalence of PA-associated diseases in a large German population. Methods: Medical records from the IQVIATM Disease Analyzer database were analyzed retrospectively. PA patients (n = 860) were matched with non-PA individuals (n = 4300) by age and sex. Associations between PA and predefined chronic diseases were examined using multivariable logistic regression. Results: PA was significantly associated with hypokalemia (7.8% vs. 1.6%, odds ratio (OR): 3.45; 95% confidence intervals (CIs): 2.41-4.96), hypertension (56.1% vs. 28.5%; OR: 2.37; 95% CIs: 2.00-2.81), hepatic steatosis (11.3% vs. 3.0%; OR: 1.85; 95% CIs: 1.34-2.57), gout (8.3% vs. 2.2%; OR: 1.64; 95% CIs: 1.15-2.35), chronic kidney disease (6.3% vs. 2.2%; OR: 1.59; 95% CIs: 1.10-2.31), diabetes mellitus not otherwise specified (7.9% vs. 2.9%; OR: 1.49; 95% CIs: 1.06-2.09), obesity (13.5% vs. 5.1%; OR: 1.38; 95% CIs: 1.05-1.82), and depression (14.8% vs. 6.2%; OR: 1.37; 95% CIs: 1.07-1.77). Conclusions: While the study design had limitations, including reliance on ICD codes for diagnosis, these findings underscore the critical need for early detection and personalized management strategies for PA to reduce associated risks and improve patient outcomes.
C1 [Krieg, Andreas; Heuser, Andreas; Laverenz, Ulrich; Istrate, Valentin-Alin] Ruhr Univ Bochum, Univ Hosp Herford, Dept Gen & Visceral Surg, Thorac Surg & Proctol, D-32049 Herford, Germany.
   [Krieg, Sarah] Bielefeld Univ, Univ Hosp Ostwestfalen Lippe, Dept Inclus Med, D-33617 Bielefeld, Germany.
   [Schott, Matthias] Heinrich Heine Univ, Div Spec Endocrinol, D-40225 Dusseldorf, Germany.
   [Schott, Matthias] Univ Hosp Duesseldorf, D-40225 Dusseldorf, Germany.
   [Kostev, Karel] IQVIA, Epidemiol, D-60549 Frankfurt, Germany.
C3 Ruhr University Bochum; University of Bielefeld; Heinrich Heine
   University Dusseldorf; IQVIA
RP Krieg, A (corresponding author), Ruhr Univ Bochum, Univ Hosp Herford, Dept Gen & Visceral Surg, Thorac Surg & Proctol, D-32049 Herford, Germany.
EM andreas.krieg@rub.de; sarah.krieg@mara.de; andreas.heuser@rub.de;
   ulrich.laverenz@klinikum-herford.de;
   valentin-alin.istrate@klinikum-herford.de;
   matthias.schott@med.uni-duesseldorf.de
RI Kostev, Karel/S-4755-2019
OI Kostev, Karel/0000-0002-2124-7227; Krieg, Andreas/0000-0003-2496-1079
FU Open Access Fund of the Ruhr University Bochum
FX The article processing charge was funded by the Open Access Fund of the
   Ruhr University Bochum.
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NR 51
TC 0
Z9 0
U1 2
U2 2
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2227-9059
J9 BIOMEDICINES
JI Biomedicines
PD NOV
PY 2024
VL 12
IS 11
AR 2479
DI 10.3390/biomedicines12112479
PG 12
WC Biochemistry & Molecular Biology; Medicine, Research & Experimental;
   Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Research & Experimental Medicine;
   Pharmacology & Pharmacy
GA N8M8P
UT WOS:001366818300001
PM 39595045
OA gold
DA 2025-06-11
ER

PT J
AU Aragno, E
   Fagiolini, A
   Cuomo, A
   Paschetta, E
   Maina, G
   Rosso, G
AF Aragno, Elena
   Fagiolini, Andrea
   Cuomo, Alessandro
   Paschetta, Elena
   Maina, Giuseppe
   Rosso, Gianluca
TI Impact of menstrual cycle events on bipolar disorder course: a narrative
   review of current evidence
SO ARCHIVES OF WOMENS MENTAL HEALTH
LA English
DT Review
DE Bipolar disorder; Women; Menarche; Menopause; Menstrual cycle; Hormonal
   mood changes
ID PREMENSTRUAL DYSPHORIC DISORDER; MENOPAUSAL TRANSITION; REPRODUCTIVE
   EVENTS; METABOLIC SYNDROME; MOOD SYMPTOMS; DEPRESSIVE SYMPTOMS;
   CARDIOVASCULAR RISK; POSTPARTUM PERIOD; MAJOR DEPRESSION; ADOLESCENT
   GIRLS
AB Several lines of research suggest that reproductive-related hormonal events may affect the course of bipolar disorder in some women. However, data on associations between bipolar disorder and menarche, menstrual cycle, and menopause are mixed. This article reviews the literature on the potential effects of menarche, menstrual cycle, and menopause on bipolar disorder. A narrative review of published articles on bipolar disorder and menstrual cycle events was conducted. The primary outcome assessed was the impact of menarche, menstrual cycle and menopause on the course of bipolar illness. Databases searched were PubMed, Ovid, Scopus, PsycINFO, Medline, and Cochrane Libraries from inception to August 2021.
   Twenty-two studies were identified and included in the narrative synthesis. Research suggested that a subset of women with bipolar disorder are vulnerable to the impact of menstrual cycle events. Menarche seems to be associated with age at onset of bipolar illness especially in case of bipolar disorder type I and the specific age at menarche may predict some clinical features of the disorder. Menstrual cycle likely affects the course of bipolar disorder but the pattern of mood variability is not clear. Menopause appears to be not only a period of vulnerability to mood alteration, especially depressive episodes, and impairment of quality of life, but also a potential trigger of bipolar illness onset.
   The impact of menarche, menstrual cycle, and menopause on bipolar disorder is largely understudied. Preliminary evidence suggests that a subset of women with bipolar disorder may have their mood shifts affected by menstrual cycle events, with different patterns depending on the type of bipolar disorder also. Further researches are needed to deep the impact of menarche, menstrual cycle, and menopause on bipolar illness.
C1 [Aragno, Elena; Maina, Giuseppe; Rosso, Gianluca] Univ Torino, Dept Neurosci Rita Levi Montalcini, Turin, Italy.
   [Fagiolini, Andrea; Cuomo, Alessandro] Univ Siena, Dept Mol Med, Siena, Italy.
   [Paschetta, Elena] Psichiat Area Nord ASL CN 1, Cuneo, Italy.
   [Maina, Giuseppe; Rosso, Gianluca] San Luigi Gonzaga Univ Hosp, Psychiat Unit, Turin, Italy.
C3 University of Turin; University of Siena; Azienda
   Ospedaliero-Universitaria San Luigi Gonzaga; University of Turin;
   University Turin Hospital
RP Rosso, G (corresponding author), Univ Torino, Dept Neurosci Rita Levi Montalcini, Turin, Italy.; Rosso, G (corresponding author), San Luigi Gonzaga Univ Hosp, Psychiat Unit, Turin, Italy.
EM gianluca.rosso@unito.it
RI Maina, Giuseppe/AAC-7158-2022; Rosso, Gianluca/N-6136-2016
OI Rosso, Gianluca/0000-0002-2308-9146
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NR 68
TC 7
Z9 7
U1 0
U2 9
PU SPRINGER WIEN
PI Vienna
PA Prinz-Eugen-Strasse 8-10, A-1040 Vienna, AUSTRIA
SN 1434-1816
EI 1435-1102
J9 ARCH WOMEN MENT HLTH
JI Arch. Womens Ment. Health
PD APR
PY 2022
VL 25
IS 2
BP 257
EP 266
DI 10.1007/s00737-022-01217-9
EA MAR 2022
PG 10
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA ZT0PE
UT WOS:000763285300001
PM 35237876
DA 2025-06-11
ER

PT J
AU Kriemler, S
   Zahner, L
   Schindler, C
   Meyer, U
   Hartmann, T
   Hebestreit, H
   Brunner-La Rocca, HP
   van Mechelen, W
   Puder, JJ
AF Kriemler, Susi
   Zahner, Lukas
   Schindler, Christian
   Meyer, Ursina
   Hartmann, Tim
   Hebestreit, Helge
   Brunner-La Rocca, Hans Peter
   van Mechelen, Willem
   Puder, Jardena J.
TI Effect of school based physical activity programme (KISS) on fitness and
   adiposity in primary schoolchildren: cluster randomised controlled trial
SO BMJ-BRITISH MEDICAL JOURNAL
LA English
DT Article
ID BODY-MASS INDEX; PREVENT CHILDHOOD OBESITY; SHUTTLE RUN TEST;
   CARDIOVASCULAR RISK; METABOLIC SYNDROME; UNITED-STATES; CHILDREN;
   ADOLESCENTS; OVERWEIGHT; HEALTH
AB Objective To assess the effectiveness of a school based physical activity programme during one school year on physical and psychological health in young schoolchildren.
   Design Cluster randomised controlled trial.
   Setting 28 classes from 15 elementary schools in Switzerland randomly selected and assigned in a 4: 3 ratio to an intervention (n=16) or control arm (n=12) after stratification for grade ( first and fifth grade), from August 2005 to June 2006.
   Participants 540 children, of whom 502 consented and presented at baseline.
   Intervention Children in the intervention arm (n=297) received a multi-component physical activity programme that included structuring the three existing physical education lessons each week and adding two additional lessons a week, daily short activity breaks, and physical activity homework. Children (n=205) and parents in the control group were not informed of an intervention group. For most outcome measures, the assessors were blinded.
   Main outcome measures Primary outcome measures included body fat ( sum of four skinfolds), aerobic fitness ( shuttle run test), physical activity (accelerometry), and quality of life ( questionnaires). Secondary outcome measures included body mass index and cardiovascular risk score ( average z score of waist circumference, mean blood pressure, blood glucose, inverted high density lipoprotein cholesterol, and triglycerides).
   Results 498 children completed the baseline and follow-up assessments ( mean age 6.9 (SD 0.3) years for first grade, 11.1 (0.5) years for fifth grade). After adjustment for grade, sex, baseline values, and clustering within classes, children in the intervention arm compared with controls showed more negative changes in the z score of the sum of four skinfolds (-0.12, 95% confidence interval -0.21 to -0.03; P=0.009). Likewise, their z scores for aerobic fitness increased more favourably (0.17, 0.01 to 0.32; P=0.04), as did those for moderate-vigorous physical activity in school (1.19, 0.78 to 1.60; P<0.001), all day moderate-vigorous physical activity (0.44, 0.05 to 0.82; P=0.03), and total physical activity in school (0.92, 0.35 to 1.50; P=0.003). Z scores for overall daily physical activity (0.21, -0.21 to 0.63) and physical quality of life (0.42, -1.23 to 2.06) as well as psychological quality of life (0.59, -0.85 to 2.03) did not change significantly.
   Conclusions A school based multi-component physical activity intervention including compulsory elements improved physical activity and fitness and reduced adiposity in children.
C1 [Kriemler, Susi; Meyer, Ursina; Hartmann, Tim] Univ Basel, Inst Exercise & Hlth Sci, CH-4052 Basel, Switzerland.
   [Kriemler, Susi; Schindler, Christian] Univ Basel, Swiss Trop & Publ Hlth Inst, CH-4052 Basel, Switzerland.
   [Hebestreit, Helge] Univ Childrens Hosp, D-97080 Wurzburg, Germany.
   [Brunner-La Rocca, Hans Peter] Med Univ Ctr Maastricht, NL-6202 Maastricht, Netherlands.
   [van Mechelen, Willem] Vrije Univ Amsterdam Med Ctr, Dept Publ & Occupat Hlth, NL-1081 Amsterdam, Netherlands.
   [van Mechelen, Willem] Vrije Univ Amsterdam Med Ctr, EM GO Inst, NL-1081 Amsterdam, Netherlands.
   [Puder, Jardena J.] Univ Lausanne, Serv Endocrinol Diabet & Metab, CH-1011 Lausanne, Switzerland.
C3 University of Basel; Swiss School of Public Health (SSPH+); University
   of Basel; Swiss Tropical & Public Health Institute; University of
   Wurzburg; Maastricht University; Maastricht University Medical Centre
   (MUMC); Vrije Universiteit Amsterdam; VU UNIVERSITY MEDICAL CENTER;
   Vrije Universiteit Amsterdam; VU UNIVERSITY MEDICAL CENTER; University
   of Lausanne
RP Kriemler, S (corresponding author), Univ Basel, Inst Exercise & Hlth Sci, CH-4052 Basel, Switzerland.
EM susi.kriemler@unibas.ch
RI Hebestreit, Helge/AAO-7110-2020; van Mechelen, Willem/C-8463-2013;
   Brunner-La Rocca, Hans-Peter/AAF-7330-2021; Meyer, Ursina/B-3919-2011;
   Schindler, Christian/D-3472-2015
OI Kriemler, Susi/0000-0002-3384-7940; Puder, Jardena/0000-0002-0460-7614;
   van Mechelen, Willem/0000-0001-7136-6382; Brunner-La Rocca,
   Hans-Peter/0000-0002-4356-8566
FU Swiss Federal Office of Sports [SWI05-013]; Swiss National Science
   Foundation [PMPDB-114401]; Diabetes Foundation of the Region of Basel;
   ESRC [ES/G007462/1] Funding Source: UKRI
FX This study was funded by the Swiss Federal Office of Sports ( grant
   number SWI05-013), the Swiss National Science Foundation ( grant number
   PMPDB-114401), and the Diabetes Foundation of the Region of Basel. The
   funding sources had no role in the design and conduct of the study or in
   the collection, management, analysis, and interpretation of the data.
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NR 39
TC 364
Z9 409
U1 3
U2 217
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 1756-1833
J9 BMJ-BRIT MED J
JI BMJ-British Medical Journal
PD FEB 23
PY 2010
VL 340
AR c785
DI 10.1136/bmj.c785
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA 561TF
UT WOS:000275001100020
PM 20179126
OA hybrid, Green Submitted, Green Accepted, Green Published
DA 2025-06-11
ER

PT J
AU Al-Mohaissen, MA
AF Al-Mohaissen, Maha A.
TI Echocardiographic assessment of primary microvascular angina and primary
   coronary microvascular dysfunction
SO TRENDS IN CARDIOVASCULAR MEDICINE
LA English
DT Article
DE Transthoracic echocardiography; Microvascular angina; Coronary
   microvascular dysfunction; Coronary flow reserve; Coronary flow velocity
   reserve; Myocardial contrast echocardiography
ID FLOW VELOCITY RESERVE; TRANSTHORACIC DOPPLER-ECHOCARDIOGRAPHY;
   MYOCARDIAL CONTRAST ECHOCARDIOGRAPHY; CARDIOVASCULAR MAGNETIC-RESONANCE;
   2ND-HARMONIC ECHO-DOPPLER; ISCHEMIC-HEART-DISEASE; ARTERY-DISEASE;
   CHEST-PAIN; BLOOD-FLOW; SYNDROME-X
AB There is an increasing interest in the role of echocardiography in the evaluation of primary microvascular angina, which is attributed to primary coronary microvascular dysfunction. Valid echocardiographic techniques are expected to facilitate the diagnosis and follow-up of these patients and would be valuable for research purposes and therapy evaluation. However, adequate echocardiographic data are lacking, and the interpretation of the limited available literature is hindered by the previous addition of microvascular angina under more inclusive entities, such as cardiac syndrome X. In experienced hands, the assessment of primary coronary microvascular dysfunction in patients with suspected primary microvascular angina, using multiple echocardiographic techniques is feasible, relatively inexpensive, and safe. Exclusion of obstructive epicardial coronary artery disease is, however, a prerequisite for diagnosis. Two-dimensional transthoracic echocardiography, routine stress echocardiography, and speckle-tracking echocardiography indirectly assess primary coronary microvascular dysfunction by evaluating potential impairment in myocardial function and lack diagnostic sensitivity and specificity. Conversely, certain echocardiographic techniques, including Doppler-derived coronary flow velocity reserve and myocardial contrast echocardiography, assess some coronary microvascular dysfunction parameters and have exhibited diagnostic and prognostic potentials. Doppler-derived coronary flow velocity reserve is the best studied and only guideline-approved echocardiographic technique for documenting coronary microvascular dysfunction in patients with suspected microvascular angina. Myocardial contrast echocardiography, by comparison, can detect heterogeneous and patchy myocardial involvement by coronary microvascular dysfunction, which is an advantage over the common practice of coronary flow velocity reserve assessment in a single vessel (commonly the left anterior descending artery) which only reflects regional microvascular function. However, there is no consensus regarding the diagnostic criteria, and expertise performing this technique is limited. Echocardiography remains underexplored and inadequately utilized in the setting of microvascular angina and coronary microvascular dysfunction. Appraisal of the current echocardiographic literature regarding coronary microvascular dysfunction and microvascular angina is important to stay current with the progress in its clinical recognition and create a basis for future research and technological advancements.& COPY; 2022 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license ( http://creativecommons.org/licenses/by-nc-nd/4.0/ )
C1 [Al-Mohaissen, Maha A.] Princess Nourah Bint Abdulrahman Univ, Coll Med, Dept Clin Sci Cardiol, Riyadh, Saudi Arabia.
   [Al-Mohaissen, Maha A.] Princess Nourah Bint Abdulrahman Univ, Coll Med, Dept Clin Sci Cardiol, POB 84428, Riyadh 11671, Saudi Arabia.
C3 Princess Nourah bint Abdulrahman University; Princess Nourah bint
   Abdulrahman University
RP Al-Mohaissen, MA (corresponding author), Princess Nourah Bint Abdulrahman Univ, Coll Med, Dept Clin Sci Cardiol, POB 84428, Riyadh 11671, Saudi Arabia.
EM maalmohaissen@pnu.edu.sa
RI Al-Mohaissen, Maha/GQO-9962-2022
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PU ELSEVIER SCIENCE LONDON
PI LONDON
PA 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND
SN 1050-1738
EI 1873-2615
J9 TRENDS CARDIOVAS MED
JI Trends Cardiovasc. Med.
PD AUG
PY 2023
VL 33
IS 6
BP 369
EP 383
DI 10.1016/j.tcm.2022.02.007
EA AUG 2023
PG 15
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA Q8CE2
UT WOS:001059739000001
PM 35192927
OA hybrid
DA 2025-06-11
ER

PT J
AU Veeramani, C
   Alsaif, MA
   Al-Numair, KS
AF Veeramani, Chinnadurai
   Alsaif, Mohammed A.
   Al-Numair, Khalid S.
TI Lavatera critica, a green leafy vegetable, controls high fat diet
   induced hepatic lipid accumulation and oxidative stress through the
   regulation of lipogenesis and lipolysis genes
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Article
DE Heavy fat diet; Fatty acid synthesis; Lipid accumulation; Hepatic
   damage; Green vegetable
ID MESSENGER-RNA EXPRESSION; INSULIN-RESISTANCE; ACID SYNTHESIS; LIVER;
   OBESITY; ANTIOXIDANT; PROFILES; SYNTHASE; EXTRACTS; ASSAY
AB Background: Lipid accumulation is the most vital risk factor for inducing nonalcoholic fatty liver disease (NAFLD) and metabolic syndrome. Thus, the development of novel drugs is urgently needed to control obesity related diseases.
   Objective: Here, we investigated the protective role of Lavatera critica (LC), a green vegetable, in male C57BL/6J mice fed with high fat (HF) diet for 10 weeks to induce hepatic lipid accumulation and oxidative cellular damage.
   Results: After oral administration of chloroform (CFLC), ethyl acetate (EFLC), or methanol (MFLC) fractions of Lavatera critica to the HF group, EALC alone significantly reduced the activities of hepatic markers such as alanine aminotransferase (ALT) and aspartate aminotransferase (AST); moreover, the results showed that 50 mg/kg dose has the maximum activity. Thus, this active dose of EFLC was used for further analysis. Moreover, EFLC reduced the level of hepatic triglycerides (TG), total cholesterol (TC), free fatty acids (FFA), and prevented further increase in the body weight. Intriguingly, EFLC treatment also reversed the mRNA expression of fatty acid oxidative genes, such as peroxisome proliferator activated receptor-a (PPAR-a), carnitine palmitoyltransferase- 1 (CPT-1), and acetyl-CoA carboxylase (ACO), and fatty acid synthesis genes such as fatty acid synthase (FAS), sterol-regulatory-element-binding protein-1c (SREBP-1c), and acetyl-CoA carboxylase (ACC). Furthermore, EFLC treatment also decreased the production of oxidative stress biomarkers, such as conjugated diene (CD), thiobarbituric acid reactive substances (TBARS), and lipid hydroperoxide (LOOH), and significantly enhanced the level of enzymatic antioxidants, such as glutathione peroxidase (GPx), superoxide dismutase (SOD), and catalase (CAT), as well as non-enzymatic antioxidants, such as reduced glutathione (GSH), vitamin C, and vitamin E in the liver.
   Conclusion: Taken together, we conclude that EFLC has a protective effect against HF diet induced hepatic lipid accumulation and oxidative cellular damage through the regulation of lipogenesis and lipolysis genes.
C1 [Veeramani, Chinnadurai; Alsaif, Mohammed A.; Al-Numair, Khalid S.] King Saud Univ, Coll Appl Med Sci, Dept Community Hlth Sci, POB 10219, Riyadh 11433, Saudi Arabia.
C3 King Saud University
RP Veeramani, C (corresponding author), King Saud Univ, Coll Appl Med Sci, Dept Community Hlth Sci, POB 10219, Riyadh 11433, Saudi Arabia.
EM chinnaveeramani@gmail.com
RI Veeramani, Chinnadurai/AGB-1859-2022
OI Chinnadurai, Dr.Veeramani/0000-0002-3549-5432
FU Deanship of Scientific Research at King Saud University [RGP-249]
FX The authors would like to extend their sincere appreciation to the
   Deanship of Scientific Research at King Saud University for its funding
   of this research through the Research Group Project No. RGP-249.
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NR 58
TC 18
Z9 18
U1 0
U2 15
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD DEC
PY 2017
VL 96
BP 1349
EP 1357
DI 10.1016/j.biopha.2017.11.072
PG 9
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA FQ6VL
UT WOS:000418502100161
PM 29174039
DA 2025-06-11
ER

PT J
AU Chen, P
   Zhang, QX
   Dang, H
   Liu, XM
   Tian, FW
   Zhao, JX
   Chen, YQ
   Zhang, H
   Chen, W
AF Chen, Pei
   Zhang, Qiuxiang
   Dang, Hui
   Liu, Xiaoming
   Tian, Fengwei
   Zhao, Jianxin
   Chen, Yongquan
   Zhang, Hao
   Chen, Wei
TI Antidiabetic effect of Lactobacillus casei CCFM0412 on mice with
   type 2 diabetes induced by a high-fat diet and streptozotocin
SO NUTRITION
LA English
DT Article
DE Lactobacillus casei CCFM0412; Antidiabetic effect; Pioglitazone; Type 2
   diabetes; Blood glucose
ID ORAL GLUCOSE-TOLERANCE; INSULIN-RESISTANCE; OXIDATIVE STRESS;
   LIPID-PEROXIDATION; ANTIOXIDANT STATUS; METABOLIC SYNDROME; GLYCEMIC
   CONTROL; MELLITUS; INTERLEUKIN-10; OBESITY
AB Objective: The aim of this study was to evaluate the antidiabetic effects of Lactobacillus casei CCFM0412 on mice with type 2 diabetes induced by a high-fat diet and streptozotocin. Methods: Thirty-two male C57 BL/6 J mice were assigned to four groups in this study. Type 2 diabetes was induced by feeding of a high-fat diet and injection of streptozotocin. L. casei CCFM0412 was administered to mice at a dose of 109 cfu/d per mouse for 12 wk. Body weight, fasting and postprandial 2-h blood glucose, oral glucose tolerance, glycosylated hemoglobin, insulin, and glycogen in liver were measured. Endotoxin, tumor necrosis factor-a, and interleukin-10 levels were determined. Lipid metabolic parameters including triglycerides, total cholesterol, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol were also measured. The activities of glutathione peroxides, reactive oxygen species, and superoxide dismutase, and the levels of glutathione and malondialdehyde in the liver also were determined. Pancreas injury was evaluated by histologic analysis. Results: At 13 wk, L. casei CCFM0412 significantly decreased fasting and postprandial 2-h blood glucose, glycosylated hemoglobin, endotoxin, tumor necrosis factor-a, triglycerides, total cholesterol, low-density lipoprotein cholesterol, reactive oxygen species, and malondialdehyde levels compared with the control group (P < 0.05). The values for insulin, interleukin-10, high-density lipoprotein cholesterol, glutathione peroxides, superoxide dismutase, glutathione, and glycogen were significantly increased at 13 wk (P < 0.05). Islets of Langerhans in the L. casei CCFM0412 group were substantially protected from destruction compared with those in the control group. Conclusion: L casei CCFM0412 significantly improved glucose intolerance, dyslipidemia, immuneregulatory properties, and oxidative stress in mice with type 2 diabetes induced by a high-fat diet and streptozotocin. The results provide a sound rationale for future clinical trials of oral administration of L casei CCFM0412 for the primary prevention of type 2 diabetes. (C) 2014 Elsevier Inc. All rights reserved.
C1 [Chen, Pei; Dang, Hui; Tian, Fengwei; Zhao, Jianxin; Chen, Wei] Jiangnan Univ, State Key Lab Food Sci & Technol, Wuxi 2, Peoples R China.
   [Chen, Pei] Shaanxi Univ Technol, Sch Biol Sci & Engn, Hanzhong, Peoples R China.
   [Zhang, Qiuxiang; Liu, Xiaoming; Chen, Yongquan; Zhang, Hao] Jiangnan Univ, Sch Food Sci & Technol, Wuxi 2, Peoples R China.
   [Dang, Hui] Shaanxi Normal Univ, Coll Food Engn & Nutr Sci, Xian, Peoples R China.
C3 Jiangnan University; Shaanxi University of Technology; Jiangnan
   University; Shaanxi Normal University
RP Chen, W (corresponding author), Jiangnan Univ, State Key Lab Food Sci & Technol, Wuxi 2, Peoples R China.
EM Chenwei66@jiangnan.edu.cn
RI Chen, Wei/AAR-9817-2020; Chen, Yong Q/AAI-9864-2021
OI /0009-0006-1337-808X; Chen, Yong Q/0000-0003-4747-4708
FU National Science Fund for Distinguished Young Scholars [31125021];
   National High Technology Research and Development Program of China (863
   Program) [2011 AA100901, 2011 AA100902]; National Natural Science
   Foundation of China [31200691]; Key Program of the National Natural
   Science Foundation of China [20836003]; National Basic Research Program
   of China (973 Program) [2012 C8720802]; National Science and Technology
   Pillar Program [2012 BAD12 608, 2012 BAD28 B07, 2010 C0070311]; 111
   project [B07029]; Fundamental Research Funds for the Central
   Universities [JUSRP111 A31]
FX This work was supported by the National Science Fund for Distinguished
   Young Scholars (No. 31125021), the National High Technology Research and
   Development Program of China (863 Program No. 2011 AA100901, 2011
   AA100902), the National Natural Science Foundation of China (No.
   31200691), the Key Program of the National Natural Science Foundation of
   China (No. 20836003), the National Basic Research Program of China (973
   Program No. 2012 C8720802), key projects in the National Science and
   Technology Pillar Program during the 12th Five-Year Plan (No. 2012 BAD12
   608, 2012 BAD28 B07), the National Science and Technology Pillar Program
   (No. 2010 C0070311), the 111 project B07029, and the Fundamental
   Research Funds for the Central Universities (JUSRP111 A31). PC, QZ, HZ,
   YC, and WC conceived of and designed the study. HD, XL, and FT were
   responsible for generation, collection, assembly, and analysis of the
   data. PC, QZ, and JZ drafted and revised the manuscript. YC and WC
   approved the final version of the manuscript. PC and QZ contributed
   equally to this work.
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NR 40
TC 93
Z9 100
U1 4
U2 70
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0899-9007
EI 1873-1244
J9 NUTRITION
JI Nutrition
PD SEP
PY 2014
VL 30
IS 9
BP 1061
EP 1068
DI 10.1016/j.nut.2014.03.022
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA AN6VI
UT WOS:000340736100017
PM 25102821
DA 2025-06-11
ER

PT J
AU Tarantino, G
   Colao, A
   Capone, D
   Conca, P
   Tarantino, M
   Grimaldi, E
   Chianese, D
   Finelli, C
   Contaldo, F
   Scopacasa, F
   Savastano, S
AF Tarantino, G.
   Colao, A.
   Capone, D.
   Conca, P.
   Tarantino, M.
   Grimaldi, E.
   Chianese, D.
   Finelli, C.
   Contaldo, F.
   Scopacasa, F.
   Savastano, S.
TI CIRCULATING LEVELS OF CYTOCHROME C, GAMMA-GLUTAMYL TRANSFERASE,
   TRIGLYCERIDES AND UNCONJUGATED BILIRUBIN IN OVERWEIGHT/OBESE PATIENTS
   WITH NON-ALCOHOLIC FATTY LIVER DISEASE
SO JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
LA English
DT Article
DE NAFLD; cytochrome c; gamma-glutamyl transferase; triglycerides;
   unconiugated bilirubin; apoptosis
ID OXIDATIVE STRESS; METABOLIC SYNDROME; IN-VIVO; APOPTOSIS; MARKER;
   TRANSPEPTIDASE; STEATOHEPATITIS; EXPRESSION; STEATOSIS; INDEX
AB Non-alcoholic fatty liver disease, characterized by hepatocyte apoptosis, is distinct in fatty liver and non-alcoholic steatohepatitis, the more severe form. Apoptotic cell death is caspase-dependent and associated with mitochondrial membrane depolarization and cytochrome c release. Adhering to the hypothesis that the exposure of hepatocytes to free fatty acids, resulting in increased ROS production and mitochondrial damage, is balanced by the presence of antioxidant substances, circulating levels of gamma-glutamyl transferase, cytochrome c, triglycerides and unconjugated bilirubin were explored in patients suffering from non-alcoholic fatty liver disease with different severity. One hundred and eighty-six consecutive patients who presented recent ultrasound feature of "bright liver" without any liver disease of known origin were enrolled, eighty-nine of whom underwent liver biopsy. Forty-five subjects were allocated on the basis of histology in fatty liver group while 44 patients formed the group with nonalcoholic steatohepatitis. A cohort of 27 young, lean, apparently healthy individuals was selected as control group. The levels of gamma-glutamyl transferase were normal or slightly increased, while unconjugated bilirubin concentrations were elevated in all the spectra of non-alcoholic fatty liver disease. Comparing the present results with relevant findings from other studies dealing with diseases characterized by apoptosis, we did not find high circulating levels of cytochrome c in non-alcoholic fatty liver disease. What is more, our patients, categorized as suffering from simple fatty liver or from the more severe nonalcoholic steatohepatitis, had similar levels of cytochrorne c and gamma-glutamyl transferase, p=0.19 and 0.11. Serum triglycerides were higher in patients with non-alcoholic fatty liver disease than in the healthy group, p=0.001. These findings likely reflect a balance between oxidative stress and anti-oxidant response rather than a lack of reliability of cytochrome c as a reliable biomarker of mitochondrial damage.
C1 [Tarantino, G.; Conca, P.; Finelli, C.; Contaldo, F.] Univ Naples Federico II, Med Sch Naples, Dept Clin & Expt Med, Naples, Italy.
   [Colao, A.; Savastano, S.] Univ Naples Federico II, Med Sch Naples, Dept Mol & Clin Endocrinol & Oncol, Endocrinol Sect, Naples, Italy.
   [Capone, D.] Univ Naples Federico II, Med Sch Naples, Dept Neurosci, Clin Pharmacol Unit, Naples, Italy.
   [Tarantino, M.] Univ Naples Federico II, Med Sch Naples, Dept Biomorphol & Funct Sci, Naples, Italy.
   [Grimaldi, E.; Chianese, D.; Scopacasa, F.] Univ Naples Federico II, Med Sch Naples, Dept Biochem & Med Biotechnol, Naples, Italy.
C3 University of Naples Federico II; University of Naples Federico II;
   University of Naples Federico II; University of Naples Federico II;
   University of Naples Federico II
RP Tarantino, G (corresponding author), Univ Naples Federico II, Med Sch Naples, Dept Clin & Expt Med, Naples, Italy.
EM tarantin@unina.it
RI Colao, Annamaria/A-7671-2011; Tarantino, Giovanni/AAW-2007-2021;
   Savastano, Silvia/K-6546-2016
OI Savastano, Silvia/0000-0002-3211-4307; Contaldo,
   Franco/0000-0002-3657-3922; Chianese, Donato/0000-0003-2437-1466;
   Giovanni, Tarantino/0000-0001-7751-2715
CR Adachi N, 2004, CLIN CHIM ACTA, V342, P127, DOI 10.1016/j.cccn.2003.12.011
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NR 35
TC 80
Z9 81
U1 0
U2 11
PU BIOLIFE SAS
PI SILVA MARINA (TE)
PA VIA S STEFANO 39 BIS, 64029 SILVA MARINA (TE), ITALY
SN 0393-974X
J9 J BIOL REG HOMEOS AG
JI J. Biol. Regul. Homeost. Agents
PD JAN-MAR
PY 2011
VL 25
IS 1
BP 47
EP 56
PG 10
WC Endocrinology & Metabolism; Immunology; Medicine, Research &
   Experimental; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Immunology; Research & Experimental
   Medicine; Physiology
GA 739BT
UT WOS:000288688000007
PM 21382273
DA 2025-06-11
ER

PT J
AU Mizgier, M
   Jarzabek-Bielecka, G
   Wendland, N
   Jodlowska-Siewert, E
   Nowicki, M
   Brozek, A
   Kedzia, W
   Formanowicz, D
   Opydo-Szymaczek, J
AF Mizgier, Malgorzata
   Jarzabek-Bielecka, Grazyna
   Wendland, Natalia
   Jodlowska-Siewert, Elzbieta
   Nowicki, Marcin
   Brozek, Alicja
   Kedzia, Witold
   Formanowicz, Dorota
   Opydo-Szymaczek, Justyna
TI Relation between Inflammation, Oxidative Stress, and Macronutrient
   Intakes in Normal and Excessive Body Weight Adolescent Girls with
   Clinical Features of Polycystic Ovary Syndrome
SO NUTRIENTS
LA English
DT Article
DE polycystic ovary syndrome; adolescent girls; obesity; diet; food
   environments; hyperandrogenism
ID C-REACTIVE PROTEIN; METABOLIC SYNDROME; INSULIN-RESISTANCE; ENDOTHELIAL
   DYSFUNCTION; ANTIOXIDANT CAPACITY; CHILDHOOD OBESITY; PASSIVE SMOKING;
   FREE-RADICALS; MASS INDEX; TNF-ALPHA
AB The impact of diet on inflammation and oxidative stress (OS) in girls with polycystic ovary syndrome (PCOS) is unknown. Therefore, our study aimed to investigate, in PCOS girls, whether certain macronutrient intakes can be associated with these disturbances. For this purpose, 59 PCOS participants (aged 14-18 years) were recruited to this study and divided into two subgroups: overweight/obese-Ov/Ob group (n = 22) and normal weight-N group (n = 37). Nutrition was assessed using a 3-day food record. The studied markers were total antioxidant capacity (TAC), malondialdehyde (MDA), C-reactive protein (CRP), tumor necrosis factor alpha (TNF-alpha), and interleukins 1 and 6 (IL-1 and IL-6). We found plant protein intake inversely correlated with IL-6 (p = 0.007; r = -0.557), TNF-alpha (p = 0.006; r = -0.564), MDA (p = 0.01; r = -0.539) in the Ov/Ob group and with TAC (p = 0.021; r = -0.38) in the N group. Inverse correlations in the Ov/Ob group were observed between protein intake and IL-6 (p = 0.031; r = -0.461), TNF- alpha (p = 0.043; r = -0.435); carbohydrates and IL-6 (p = 0.037; r = -0.448), MDA (p = 0.045; r = -0.431); fiber and IL-6 (p = 0.025; r = -0.475). A positive relationship between cholesterol intake and CRP concentration (p = 0.038; r = 0.342) was also found in the N group. These findings revealed that inflammation and OS are increased in Ov/Ob girls with decreased plant protein intake and low carbohydrates in the diet. Moreover, inflammation may be increased by cholesterol intake in slim PCOS girls. On the other hand, decreased intake of fiber and total protein intake increased inflammation. ClinicalTrials.gov Identifier: NCT04738409.
C1 [Mizgier, Malgorzata] Poznan Univ Phys Educ, Fac Phys Culture Gorzow Wlkp, Dept Dietet, Estkowskiego 13, PL-66400 Gorzow Wielkopolski, Poland.
   [Jarzabek-Bielecka, Grazyna; Kedzia, Witold] Poznan Univ Med Sci, Dept Perinatol & Gynecol, Div Dev Gynecol & Sexol, PL-60535 Poznan, Poland.
   [Wendland, Natalia; Opydo-Szymaczek, Justyna] Poznan Univ Med Sci, Dept Pediat Dent, Chair Pediat Dent, PL-60812 Poznan, Poland.
   [Jodlowska-Siewert, Elzbieta] Poznan Univ Med Sci, Dept Comp Sci & Stat, PL-60806 Poznan, Poland.
   [Nowicki, Marcin; Brozek, Alicja; Formanowicz, Dorota] Poznan Univ Med Sci, Chair & Dept Med Chem & Lab Med, PL-60806 Poznan, Poland.
C3 Poznan University of Medical Sciences; Poznan University of Medical
   Sciences; Poznan University of Medical Sciences; Poznan University of
   Medical Sciences
RP Mizgier, M (corresponding author), Poznan Univ Phys Educ, Fac Phys Culture Gorzow Wlkp, Dept Dietet, Estkowskiego 13, PL-66400 Gorzow Wielkopolski, Poland.
EM m.mizgier@awf-gorzow.edu.pl; grajarz@tlen.pl; nataliakryszan@interia.pl;
   youleadmeastray@gmail.com; nowickim@ump.edu.pl; abrozek@ump.edu.pl;
   witold.kedzia@poczta.fm; doforman@ump.edu.pl; jopydo@ump.edu.pl
RI Opydo-Szymaczek, Justyna/AAO-8367-2021; Mizgier,
   Małgorzata/AAN-7720-2020; Formanowicz, Dorota/V-3901-2019
OI Formanowicz, Dorota/0000-0001-6691-3863; MIZGIER,
   MALGORZATA/0000-0002-9533-2950
FU National Science Centre in Poland [2019/03/X/NZ7/01068]
FX This research was funded by the National Science Centre in Poland, grant
   number 2019/03/X/NZ7/01068.
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NR 106
TC 38
Z9 40
U1 1
U2 11
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD MAR
PY 2021
VL 13
IS 3
AR 896
DI 10.3390/nu13030896
PG 15
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA RE2HI
UT WOS:000633981700001
PM 33801995
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Rasiah, R
   Thangiah, G
   Yusoff, K
   Manikam, R
   Chandrasekaran, SK
   Mustafa, R
   Abu Bakar, NB
AF Rasiah, Rajah
   Thangiah, Govindamal
   Yusoff, Khalid
   Manikam, Rishya
   Chandrasekaran, Sankara Kumar
   Mustafa, Rujhan
   Abu Bakar, Najmin Binti
TI The impact of physical activity on cumulative cardiovascular disease
   risk factors among Malaysian adults
SO BMC PUBLIC HEALTH
LA English
DT Article
DE Cumulative cardiovascular disease risk factors; Physical activity;
   Socio-demographic factors
ID PUBLIC-HEALTH; METABOLIC SYNDROME; HIGH-INCOME; POPULATION; PREVENTION;
   MIDDLE; URBANIZATION; INACTIVITY; MORTALITY; EVENTS
AB Background: Numerous studies have shown the importance of physical activity in reducing the morbidity and mortality rates caused by cardiovascular disease (CVD). However, most of these studies emphasise little on the cumulative effect of CVD risk factors. Hence, this study investigates the association between physical exercise and cumulative CVD risk factors among adults in three different age groups.
   Methods: Using a sample of 7276 respondents drawn from community centers, the REDISCOVER team gathered information on physical activity, CVD risk factors (obesity, diabetes, hypertension, hypercholesterolemia, tobacco use) and socioeconomic and demographic variables in Malaysia. Because the study required medical examination, a convenience sampling frame was preferred in which all volunteers were included in the study. Fasting blood samples and anthropometric (height, weight and more) measurements were collected by trained staffs. Socio-demographic and physical activity variables were recorded through questionnaires. A Chi-square test was performed to identify the bivariate association between the covariates (socioeconomic variables, demographic variables and physical activity) and outcome variable. The association between the main exposure, physical activity, and the outcome variable, cumulative CVD risk factors, was assessed using an ordinal logistic regression model, controlling for socioeconomic status and demographic influences in three different age groups, 35-49, 50-64 and 65 and above.
   Results: The mean age of participants is 51.8 (SD = 9.4). Respondents in the age groups of 35-49 (aOR(moderate) = 0.12; 95 % CI: 0.02 - 0.53) and 65 and above (aOR(high) = 0.58; 95 % CI: 0.24, 0.78) showed a statistically significant inverse relationship between physical activity and cumulative CVD risk factors. However, this relationship was not significant among respondents in the 50-64 age group suggesting the possible influence of other variables, such as stress and environment.
   Conclusions: The statistically significant results show a negative association between physical exercise and cumulative CVD risk factors. However, the lack of a significant relationship in the 50-64 age group suggests the need to include other considerations in future studies, such as stress and environment.
C1 [Rasiah, Rajah; Thangiah, Govindamal] Univ Malaya, Dept Dev Studies, Fac Econ & Adm, Kuala Lumpur 50603, Malaysia.
   [Manikam, Rishya; Chandrasekaran, Sankara Kumar] Univ Malaya, Fac Med, Kuala Lumpur 50603, Malaysia.
   [Yusoff, Khalid; Abu Bakar, Najmin Binti] Univ Teknol MARA UiTM, Fac Med, Sungai Buloh 47000, Selangor, Malaysia.
   [Mustafa, Rujhan] Malaysian Qualifying Agcy, Petaling Jaya, Malaysia.
C3 Universiti Malaya; Universiti Malaya
RP Rasiah, R (corresponding author), Univ Malaya, Dept Dev Studies, Fac Econ & Adm, Kuala Lumpur 50603, Malaysia.
EM rajah@um.edu.my
RI RASIAH, RAJAH/B-9552-2010; Manikam, Rishya/F-5908-2014; Yusoff,
   Khalid/I-7029-2019
OI , Najmin Abu Bakar/0009-0007-4126-5469
FU Ministry of Higher Education of Malaysia under Long Term Research Grant
   Scheme (LRGS) program [Nbr 600 -RMI/LRGS5/32/2011]
FX We would like to thank the Ministry of Higher Education of Malaysia for
   funding the project under the Long Term Research Grant Scheme (LRGS)
   program. Reference No. : Nbr 600 -RMI/LRGS5/32/2011. The funders had no
   role in study design, data collection and analysis, decision to publish
   or preparation of the manuscript. We would also like to thank the
   reviewers for their comments given.
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NR 35
TC 10
Z9 11
U1 0
U2 25
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2458
J9 BMC PUBLIC HEALTH
JI BMC Public Health
PD DEC 16
PY 2015
VL 15
AR 1242
DI 10.1186/s12889-015-2577-5
PG 9
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA CY6XO
UT WOS:000366552300002
PM 26673166
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Guo, ZX
   Zhang, R
   Li, JW
   Xu, GJ
AF Guo, Zhixin
   Zhang, Rong
   Li, Jiawei
   Xu, Guojun
TI Effect of telmisartan on the expression of adiponectin receptors and
   nicotinamide adenine dinucleotide phosphate oxidase in the heart and
   aorta in type 2 diabetic rats
SO CARDIOVASCULAR DIABETOLOGY
LA English
DT Article
DE Telmisartan; Adiponectin receptor; NADPH oxidase; Type 2 diabetic;
   Cardiac; Aorta
ID ACTIVATED PROTEIN-KINASE; OXIDATIVE STRESS; PPAR-GAMMA; NADPH OXIDASE;
   ENDOTHELIAL DYSFUNCTION; METABOLIC SYNDROME; FAILING HEART; MICE;
   MELLITUS; ALPHA
AB Background: Diabetic cardiovascular disease is associated with decreased adiponectin and increased oxidative stress. This study investigated the effect of telmisartan on the expression of adiponectin receptor 2 (adipoR2) and nicotinamide adenine dinucleotide phosphate (NADPH) oxidase subunits in the heart and the expression of adiponectin receptor 1 (adipoR1) in aorta in type 2 diabetic rats.
   Methods: Type 2 diabetes was induced by high-fat and high-sugar diet and intraperitoneal injection of a low dose of streptozotocin (STZ). Heart function, adipoR2, p22phox, NOX4, glucose transporter 4(GLUT4), monocyte chemoattractant protein-1(MCP-1) and connective tissue growth factor (CTGF) in the heart, and adipoR1, MCP-1 and nuclear factor kappa B (NF-kappa B) in aorta were analyzed in controls and diabetic rats treated with or without telmisartan (5mg/kg/d) by gavage for 12 weeks.
   Results: Heart function, plasma and myocardial adiponectin levels, the expression of myocardial adipoR2 and GLUT4 were significantly decreased in diabetic rats (P<0.05). The expression of myocardial p22phox, NOX4, MCP-1, and CTGF was significantly increased in diabetic rats (P<0.05). The expression of adipoR1 was decreased and the expression of MCP-1 and NF-kB was increased in the abdominal aorta in diabetic rats (P<0.05). Telmisartan treatment significantly attenuated these changes in diabetic rats (P<0.05).
   Conclusions: Our results suggest that telmisartan upregulates the expression of myocardial adiponectin, its receptor 2 and GLUT4. Simultaneously, it downregulates the expression of myocardial p22phox, NOX4, MCP-1, and CTGF, contributing so to the improvement of heart function in diabetic rats. Telmisartan also induces a protective role on the vascular system by upregulating the expression of adipoR1 and downregulating the expression of MCP-1 and NF-kappa B in the abdominal aorta in diabetic rats.
C1 [Guo, Zhixin; Zhang, Rong; Li, Jiawei; Xu, Guojun] Shanxi Med Univ, Hosp 2, Dept Endocrinol, Taiyuan 030001, Shanxi, Peoples R China.
C3 Shanxi Medical University
RP Guo, ZX (corresponding author), Shanxi Med Univ, Hosp 2, Dept Endocrinol, 382 Wuyi Rd, Taiyuan 030001, Shanxi, Peoples R China.
EM zhxguo1966@yahoo.com.cn
RI Jiawei, Li/AAS-7247-2020; Guo, Zhixin/M-3550-2019; Zhang,
   Rong/KLC-0982-2024
FU Shanxi Scholarship Council of China [2007-44, 2011-48]; Department of
   Personnel of Shanxi Province of China
FX This work was supported by the grant (No. 2007-44 and 2011-48) from
   Shanxi Scholarship Council of China and the grant from Department of
   Personnel of Shanxi Province of China in aid for the excellent projects
   picked out in technological activity.
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NR 48
TC 29
Z9 35
U1 0
U2 10
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1475-2840
J9 CARDIOVASC DIABETOL
JI Cardiovasc. Diabetol.
PD AUG 8
PY 2012
VL 11
AR 94
DI 10.1186/1475-2840-11-94
PG 12
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism
GA 026TS
UT WOS:000310305100001
PM 22873349
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU States, JC
   Singh, AV
   Knudsen, TB
   Rouchka, EC
   Ngalame, NO
   Arteel, GE
   Piao, YL
   Ko, MSH
AF States, J. Christopher
   Singh, Amar V.
   Knudsen, Thomas B.
   Rouchka, Eric C.
   Ngalame, Ntube O.
   Arteel, Gavin E.
   Piao, Yulan
   Ko, Minoru S. H.
TI Prenatal Arsenic Exposure Alters Gene Expression in the Adult Liver to a
   Proinflammatory State Contributing to Accelerated Atherosclerosis
SO PLOS ONE
LA English
DT Article
ID SYSTEMIC ARTERIAL-DISEASE; DRINKING-WATER; RHEUMATOID-ARTHRITIS;
   CARDIOVASCULAR-DISEASE; EPIDEMIOLOGIC EVIDENCE; HEPATIC EXPRESSION;
   TRAUMA-HEMORRHAGE; OXIDATIVE STRESS; IN-UTERO; MICE
AB The mechanisms by which environmental toxicants alter developmental processes predisposing individuals to adult onset chronic disease are not well-understood. Transplacental arsenic exposure promotes atherogenesis in apolipoprotein E-knockout (ApoE(-/-)) mice. Because the liver plays a central role in atherosclerosis, diabetes and metabolic syndrome, we hypothesized that accelerated atherosclerosis may be linked to altered hepatic development. This hypothesis was tested in ApoE(-/-) mice exposed to 49 ppm arsenic in utero from gestational day (GD) 8 to term. GD18 hepatic arsenic was 1.2 mu g/g in dams and 350 ng/g in fetuses. The hepatic transcriptome was evaluated by microarray analysis to assess mRNA and microRNA abundance in control and exposed pups at postnatal day (PND) 1 and PND70. Arsenic exposure altered postnatal developmental trajectory of mRNA and microRNA profiles. We identified an arsenic exposure related 51-gene signature at PND1 and PND70 with several hubs of interaction (Hspa8, IgM and Hnf4a). Gene ontology (GO) annotation analyses indicated that pathways for gluconeogenesis and glycolysis were suppressed in exposed pups at PND1, and pathways for protein export, ribosome, antigen processing and presentation, and complement and coagulation cascades were induced by PND70. Promoter analysis of differentially-expressed transcripts identified enriched transcription factor binding sites and clustering to common regulatory sites. SREBP1 binding sites were identified in about 16% of PND70 differentially-expressed genes. Western blot analysis confirmed changes in the liver at PND70 that included increases of heat shock protein 70 (Hspa8) and active SREBP1. Plasma AST and ALT levels were increased at PND70. These results suggest that transplacental arsenic exposure alters developmental programming in fetal liver, leading to an enduring stress and proinflammatory response postnatally that may contribute to early onset of atherosclerosis. Genes containing SREBP1 binding sites also suggest pathways for diabetes mellitus and rheumatoid arthritis, both diseases that contribute to increased cardiovascular disease in humans.
C1 [States, J. Christopher; Ngalame, Ntube O.; Arteel, Gavin E.] Univ Louisville, Dept Pharmacol & Toxicol, Louisville, KY 40292 USA.
   [States, J. Christopher; Singh, Amar V.; Knudsen, Thomas B.; Rouchka, Eric C.; Arteel, Gavin E.] Univ Louisville, Ctr Environm Genom & Integrat Biol, Louisville, KY 40292 USA.
   [States, J. Christopher; Knudsen, Thomas B.; Rouchka, Eric C.; Arteel, Gavin E.] Univ Louisville, Ctr Genet & Mol Med, Louisville, KY 40292 USA.
   [Singh, Amar V.; Knudsen, Thomas B.] Univ Louisville, Dept Mol Cellular & Craniofacial Biol, Louisville, KY 40292 USA.
   [Rouchka, Eric C.] Univ Louisville, Dept Comp Engn & Comp Sci, Louisville, KY 40292 USA.
   [Piao, Yulan; Ko, Minoru S. H.] Natl Inst Aging, Genet Lab, Baltimore, MD USA.
C3 University of Louisville; University of Louisville; University of
   Louisville; University of Louisville; University of Louisville; National
   Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA)
RP States, JC (corresponding author), Univ Louisville, Dept Pharmacol & Toxicol, Louisville, KY 40292 USA.
EM jcstates@louisville.edu
RI States, J./H-4246-2011; Rouchka, Eric/A-8545-2008; Singh,
   Amar/K-4400-2013; Arteel, Gavin/AAE-2440-2022; Ko, Minoru/B-7969-2009
OI States, J. Christopher/0000-0003-4717-4422; Singh,
   Amar/0000-0003-3780-8233; Arteel, Gavin/0000-0002-2253-5984; Ngalame,
   Ntube/0000-0003-4482-7272; Ko, Minoru/0000-0002-3530-3015
FU National Institutes of Health [R01ES011314, R21ES015812, P20RR016481,
   P20RR016481S1, P30ES014443]; University of Louisville Center for
   Genetics and Molecular Medicine; University of Louisville Collaborative
   Planning and Development Grant; Intramural Research Program of NIA/NIH;
   Bioinformatics, Biostatistics and Computational Biology Core of the
   Center for Environmental Genomics and Integrative Biology [P30ES014443]
FX This work was supported in part by National Institutes of Health
   (http://projectreporter.nih.gov/reporter.cfm) grants R01ES011314 (JCS),
   R21ES015812 (JCS), P20RR016481 (ECR), P20RR016481S1 (ECR), P30ES014443,
   a pilot grant from University of Louisville Center for Genetics and
   Molecular Medicine (JCS), a University of Louisville Collaborative
   Planning and Development Grant (TBK), and the Intramural Research
   Program of NIA/NIH (MSHK). Bioinformatics support was provided by the
   Bioinformatics, Biostatistics and Computational Biology Core of the
   Center for Environmental Genomics and Integrative Biology (P30ES014443).
   No additional external funding received for this study. The funders had
   no role in study design, data collection and analysis, decision to
   publish, or preparation of the manuscript.
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NR 79
TC 56
Z9 62
U1 0
U2 17
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JUN 15
PY 2012
VL 7
IS 6
AR e38713
DI 10.1371/journal.pone.0038713
PG 15
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 959WX
UT WOS:000305350000021
PM 22719926
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Dias, JP
   Couture, R
AF Dias, J. P.
   Couture, R.
TI Blockade of kinin B1 receptor reverses plasma fatty acids composition
   changes and body and tissue fat gain in a rat model of insulin
   resistance
SO DIABETES OBESITY & METABOLISM
LA English
DT Article
DE adipose tissue; fatty acids; inflammation; insulin resistance; Kinin
   B1R; obesity
ID NITRIC-OXIDE SYNTHASE; TUMOR-NECROSIS-FACTOR; HUMAN ADIPOSE-TISSUE;
   METABOLIC SYNDROME; B-1 RECEPTOR; OXIDATIVE STRESS; TNF-ALPHA; SENSORY
   ABNORMALITIES; RISK-FACTORS; WEIGHT-LOSS
AB Aim: Kinin B1 receptor (B1R) contributes to insulin resistance through a mechanism involving oxidative stress. This study examined the effect of B1R blockade on the changes in plasma fatty acids composition, body and tissue fat mass and adipose tissue inflammation that influence insulin resistance.
   Methods: Sprague-Dawley rats were fed with 10% D-glucose or tap water Control) for 13 weeks and during the last week, rats were administered the B1R antagonist SSR240612 10 mg/kg/day, gavage) or vehicle. The following parameters were assessed: plasma fatty acids by gas chromatography), body composition by EchoMRI), metabolic hormone levels by radioimmunoassay), expression of B1R and inflammatory markers in adipose tissue by Western blot and qRT-PCR).
   Results: Glucose feeding significantly increased plasma levels of glucose, insulin, leptin, palmitoleic acid 16: 1n-7), oleic acid 18: 1n-9), Delta 6 and Delta 9 desaturases while linoleic acid 18: 2n-6), arachidonic acid 20: 4n-6) and Delta 5 desaturase were decreased. SSR240612 reduced plasma levels of insulin, glucose, the homeostasis model assessment index of insulin resistance, palmitoleic acid and n-7 family. Alterations of Delta 5, Delta 6 and Delta 9 desaturases were normalized by SSR240612. The B1R antagonist also reversed the enhancing effect of glucose feeding on whole body and epididymal fat mass and on the expression of macrophage CD68, interleukin-1 beta, tumour necrosis factor-alpha and inducible nitric oxide synthase in retroperitoneal adipose tissue. B1R protein and mRNA were not detected in retroperitoneal adipose tissue.
   Conclusion: Insulin resistance in glucose-fed rats is associated with low state inflammation in adipose tissue and plasma fatty acids changes which are reversed by B1R blockade. These beneficial effects may contribute to insulin sensitivity improvement and the prevention of obesity.
C1 [Dias, J. P.; Couture, R.] Univ Montreal, Fac Med, Dept Physiol, Montreal, PQ H3C 3J7, Canada.
C3 Universite de Montreal
RP Couture, R (corresponding author), Univ Montreal, Fac Med, Dept Physiol, CP 6128,Succursale Ctr Ville, Montreal, PQ H3C 3J7, Canada.
EM rejean.couture@umontreal.ca
FU Heart and Stroke Foundation of Quebec; Canadian Institutes of Health
   Research
FX Supported by a Grant-in-aid from the Heart and Stroke Foundation of
   Quebec (to R. Couture). J. P. Dias holds a Studentship Award from the
   Canadian Institutes of Health Research (Frederick Banting and Charles
   Best Canada Graduate Scholarships-Doctoral Award). Authors are most
   grateful to Dr Emile Levy's laboratory (Department of Nutrition,
   Ste-Justine Research Center, Universite de Montreal) for the measurement
   of plasma fatty acids, to Dr Pierrette Gaudreau (Research
   Center-Technopole Angus-CHUM, Universite de Montreal) for giving access
   to the EchoMRI.
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NR 57
TC 25
Z9 27
U1 0
U2 2
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1462-8902
J9 DIABETES OBES METAB
JI Diabetes Obes. Metab.
PD MAR
PY 2012
VL 14
IS 3
BP 244
EP 253
DI 10.1111/j.1463-1326.2011.01521.x
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 894LP
UT WOS:000300428500007
PM 22023455
DA 2025-06-11
ER

PT J
AU Maiorana, A
   Tagliaferri, F
   Dionisi-Vici, C
AF Maiorana, Arianna
   Tagliaferri, Francesco
   Dionisi-Vici, Carlo
TI Current understanding on pathogenesis and effective treatment of
   glycogen storage disease type Ib with empagliflozin: new insights coming
   from diabetes for its potential implications in other metabolic
   disorders
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Review
DE glycogen storage diseases; hypoglycemia; empagliflozin; neutropenia;
   neutrophil dysfunction; inflammatory bowel disease; autophagy
ID COTRANSPORTER 2 INHIBITION; COLONY-STIMULATING FACTOR; FATTY
   LIVER-DISEASE; NF-KAPPA-B; OXIDATIVE STRESS; URIC-ACID; PERIPHERAL
   NEUROPATHY; SGLT-2 INHIBITORS; END-PRODUCTS; FETUIN-A
AB Glycogen storage type Ib (GSDIb) is a rare inborn error of metabolism caused by glucose-6-phosphate transporter (G6PT, SLC37A4) deficiency. G6PT defect results in excessive accumulation of glycogen and fat in the liver, kidney, and intestinal mucosa and into both glycogenolysis and gluconeogenesis impairment. Clinical features include hepatomegaly, hypoglycemia, lactic acidemia, hyperuricemia, hyperlipidemia, and growth retardation. Long-term complications are liver adenoma, hepatocarcinoma, nephropathy and osteoporosis. The hallmark of GSDIb is neutropenia, with impaired neutrophil function, recurrent infections and inflammatory bowel disease. Alongside classical nutritional therapy with carbohydrates supplementation and immunological therapy with granulocyte colony-stimulating factor, the emerging role of 1,5-anhydroglucitol in the pathogenesis of neutrophil dysfunction led to repurpose empagliflozin, an inhibitor of the renal glucose transporter SGLT2: the current literature of its off-label use in GSDIb patients reports beneficial effects on neutrophil dysfunction and its clinical consequences. Surprisingly, this glucose-lowering drug ameliorated the glycemic and metabolic control in GSDIb patients. Furthermore, numerous studies from big cohorts of type 2 diabetes patients showed the efficacy of empagliflozin in reducing the cardiovascular risk, the progression of kidney disease, the NAFLD and the metabolic syndrome. Beneficial effects have also been described on peripheral neuropathy in a prediabetic rat model. Increasing evidences highlight the role of empagliflozin in regulating the cellular energy sensors SIRT1/AMPK and Akt/mTOR, which leads to improvement of mitochondrial structure and function, stimulation of autophagy, decrease of oxidative stress and suppression of inflammation. Modulation of these pathways shift the oxidative metabolism from carbohydrates to lipids oxidation and results crucial in reducing insulin levels, insulin resistance, glucotoxicity and lipotoxicity. For its pleiotropic effects, empagliflozin appears to be a good candidate for drug repurposing also in other metabolic diseases presenting with hypoglycemia, organ damage, mitochondrial dysfunction and defective autophagy.
C1 [Maiorana, Arianna; Dionisi-Vici, Carlo] Osped Pediat Bambino Gesu, IRCCS, Div Metab, Rome, Italy.
   [Tagliaferri, Francesco] Univ Piemonte Orientale, SCDU Pediat, Azienda Osped Univ Maggiore Carita, Novara, Italy.
C3 IRCCS Bambino Gesu; University of Eastern Piedmont Amedeo Avogadro;
   Azienda Ospedaliera Maggiore della Carita di Novara
RP Maiorana, A (corresponding author), Osped Pediat Bambino Gesu, IRCCS, Div Metab, Rome, Italy.
EM arianna.maiorana@opbg.net
RI Maiorana, Arianna/AAA-6517-2020; Dionisi-Vici, Carlo/K-2045-2018;
   Tagliaferri, Francesco/LSJ-6018-2024
OI Tagliaferri, Francesco/0000-0002-8006-368X
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NR 145
TC 11
Z9 11
U1 0
U2 5
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD APR 21
PY 2023
VL 14
AR 1145111
DI 10.3389/fendo.2023.1145111
PG 17
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA F3MF4
UT WOS:000981411600001
PM 37152929
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Castellanos-Gutiérrez, A
   Sánchez-Pimienta, TG
   Carriquiry, A
   da Costa, THM
   Ariza, AC
AF Castellanos-Gutierrez, Anali
   Sanchez-Pimienta, Tania G.
   Carriquiry, Alicia
   da Costa, Teresa H. M.
   Carolina Ariza, Ana
TI Higher dietary magnesium intake is associated with lower body mass
   index, waist circumference and serum glucose in Mexican adults
SO NUTRITION JOURNAL
LA English
DT Article
DE Obesity; Magnesium; Glucose; Mexico; Adult
ID METABOLIC SYNDROME; OXIDATIVE STRESS; ENERGY-INTAKE; ABDOMINAL OBESITY;
   VITAMIN-C; PREVALENCE; PROTEIN; QUESTIONNAIRE; ANTIOXIDANT; WEIGHT
AB Background: Obesity and diabetes mellitus (DM) are public health concerns in Mexico of top-level priority due to their high prevalence and their growth rate in recent decades. The accumulation of adipose tissue leads to an unbalanced release of pro-oxidant factors, which causes cellular damage and favors the development of comorbidities. Recent evidence suggests that oxidative stress also promotes the accumulation of adipose tissue and the development of insulin resistance. The objective of this study is to evaluate the association between usual intake of antioxidant nutrients, specifically vitamins A, C, E and magnesium with body mass index (BMI), waist circumference (WC) and serum glucose concentrations in a representative sample of Mexican adults.
   Methodology: We analyzed data on diet, BMI, WC and serum glucose from the Mexican National Health and Nutrition Survey 2012. Analysis included 20- to 65-year-old adults without a known diagnosis of DM (n = 1573). Dietary information was obtained using the five-step multiple-pass method developed by the United States Department of Agriculture and adapted to the Mexican context. Nutrient usual intake distributions were estimated using the Iowa State University method, through the "Software for Intake Distribution Estimation" (PC-Side) v.1.02. Associations were analyzed using multivariate regression models.
   Results: Higher dietary magnesium intake was associated with lower markers of adiposity, so that an increase in 10 mg per 1000 kcal/day of magnesium was associated with an average decrease in BMI of 0.72% (95% CI: -1.36, -0.08) and 0.49 cm (95% CI: -0.92, -0.07) of WC. Additionally, in women with normal glucose concentrations, an increase in magnesium intake was associated with an average decrease in serum glucose by 0.59% (95% CI: -1.08, -0.09).
   Conclusion: The results suggest that magnesium intake is associated with lower BMI, WC and serum glucose in Mexican population. However, more studies are required to elucidate the nature of this association.
C1 [Castellanos-Gutierrez, Anali; Sanchez-Pimienta, Tania G.] Natl Inst Publ Hlth, Ctr Nutr & Hlth Res, Mexico Av Univ 655, Cuernavaca 62100, Morelos, Mexico.
   [Carriquiry, Alicia] Iowa State Univ, Dept Stat, Ames, IA 50011 USA.
   [da Costa, Teresa H. M.] Univ Brasilia, Sch Hlth Sci, Dept Nutr, BR-70910900 Brasilia, DF, Brazil.
   [Carolina Ariza, Ana] Natl Inst Publ Hlth, Ctr Nutr & Hlth Res, Nat Council Sci & Technol CONACYT, Cuernavaca, Morelos, Mexico.
C3 Instituto Nacional de Salud Publica; Iowa State University; Universidade
   de Brasilia; Instituto Nacional de Salud Publica
RP Ariza, AC (corresponding author), Natl Inst Publ Hlth, Ctr Nutr & Hlth Res, Nat Council Sci & Technol CONACYT, Cuernavaca, Morelos, Mexico.
EM carolina.ariza@insp.mx
RI Ariza, Ana/AAR-2607-2021; da Costa, Teresa/H-8434-2013
OI Sanchez Pimienta, Tania Georgina/0000-0002-7743-0047; Ariza, Ana
   Carolina/0000-0002-0302-4062
FU CONACYT
FX CONACYT contributed with travel expenses for ACG to work with AC and THM
   at ISU for a period of six weeks.
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NR 65
TC 44
Z9 49
U1 0
U2 6
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1475-2891
J9 NUTR J
JI Nutr. J.
PD DEC 5
PY 2018
VL 17
AR 114
DI 10.1186/s12937-018-0422-2
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA HD2DZ
UT WOS:000452322600001
PM 30518394
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Dohrn, MF
   Dumke, C
   Hornemann, T
   Nikolin, S
   Lampert, A
   Espenkott, V
   Vollert, J
   Ouwenbroek, A
   Zanella, M
   Schulz, JB
   Gess, B
   Rolke, R
AF Dohrn, Maike F.
   Dumke, Christina
   Hornemann, Thorsten
   Nikolin, Stefan
   Lampert, Angelika
   Espenkott, Volker
   Vollert, Jan
   Ouwenbroek, Annabelle
   Zanella, Martina
   Schulz, Jorg B.
   Gess, Burkhard
   Rolke, Roman
TI Deoxy-sphingolipids, oxidative stress, and vitamin C correlate with
   qualitative and quantitative patterns of small fiber dysfunction and
   degeneration
SO PAIN
LA English
DT Article
DE Small fiber neuropathy; Neuropathic pain; Idiopathic neuropathy;
   Quantitative sensory testing; 1-deoxy-sphingolipids
ID PERIPHERAL NEUROPATHIC PAIN; POLYNEUROPATHY; EXPRESSION; DIAGNOSIS;
   SKIN; TOOL
AB Defined by dysfunction or degeneration of A delta and C fibers, small fiber neuropathies (SFNs) entail a relevant health burden. In 50% of cases, the underlying cause cannot be identified or treated. In 100 individuals (70% female individuals; mean age: 44.8 years) with an idiopathic, skin biopsy-confirmed SFN, we characterized the symptomatic spectrum and measured markers of oxidative stress (vitamin C, selenium, and glutathione) and inflammation (transforming growth factor beta, tumor necrosis factor alpha), as well as neurotoxic 1-deoxy-sphingolipids. Neuropathic pain was the most abundant symptom (95%) and cause of daily life impairment (72%). Despite the common use of pain killers (64%), the painDETECT questionnaire revealed scores above 13 points in 80% of patients. In the quantitative sensory testing (QST), a dysfunction of A delta fibers was observed in 70% and of C fibers in 44%, affecting the face, hands, or feet. Despite normal nerve conduction studies, QST revealed A beta fiber involvement in 46% of patients' test areas. Despite absence of diabetes mellitus or mutations in SPTLC1 or SPTLC2, plasma 1-deoxy-sphingolipids were significantly higher in the sensory loss patient cluster when compared with those in patients with thermal hyperalgesia (P < 0.01) or those in the healthy category (P < 0.1), correlating inversely with the intraepidermal nerve fiber density (1-deoxy-SA: P < 0.05, 1-deoxy-SO: P < 0.01). Patients with arterial hypertension, overweight (body mass index > 25 kg/m(2)), or hyperlipidemia showed significantly lower L-serine (arterial hypertension: P < 0.01) and higher 1-deoxy-sphingolipid levels (arterial hypertension: P < 0.001, overweight: P < 0.001, hyperlipidemia: P < 0.01). Lower vitamin C levels correlated with functional A beta involvement (P < 0.05). Reduced glutathione was lower in patients with A delta dysfunction (P < 0.05). Idiopathic SFNs are heterogeneous. As a new pathomechanism, plasma 1-deoxy-sphingolipids might link the metabolic syndrome with small fiber degeneration.
C1 [Dohrn, Maike F.; Dumke, Christina; Ouwenbroek, Annabelle; Schulz, Jorg B.; Gess, Burkhard] Rhein Westfal TH Aachen, Med Fac, Dept Neurol, Aachen, Germany.
   [Dohrn, Maike F.] Univ Miami, Dr John T Macdonald Fdn, Miller Sch Med, Dept Human Genet, Miami, FL USA.
   [Dohrn, Maike F.] Univ Miami, John P Hussman Inst Human Genom, Miller Sch Med, Miami, FL USA.
   [Hornemann, Thorsten; Zanella, Martina] Univ Hosp Zurich, Inst Clin Chem, Zurich, Switzerland.
   [Nikolin, Stefan] Rhein Westfal TH Aachen, Med Fac, Inst Neuropathol, Aachen, Germany.
   [Lampert, Angelika] Rhein Westfal TH Aachen, Med Fac, Inst Physiol, Aachen, Germany.
   [Espenkott, Volker; Rolke, Roman] Rhein Westfal TH Aachen, Med Fac, Dept Palliat Med, Pauwelsstr 30, D-52074 Aachen, Germany.
   [Vollert, Jan] Imperial Coll London, Dept Surg & Canc MSK, Pain Res, London, England.
   [Vollert, Jan] Univ Hosp Schleswig Holstein, Dept Neurol, Div Neurol Pain Res & Therapy, Campus Kiel, Kiel, Germany.
   [Vollert, Jan] Univ Hosp Muenster, Dept Anaesthesiol Intens Care & Pain Med, Munster, Germany.
   [Vollert, Jan] Heidelberg Univ, Med Fac Mannheim, Mannheim Ctr Translat Neurosci MCTN, Neurophysiol, Heidelberg, Germany.
C3 RWTH Aachen University; University of Miami; University of Miami;
   University of Zurich; University Zurich Hospital; RWTH Aachen
   University; RWTH Aachen University; RWTH Aachen University; Imperial
   College London; University of Kiel; Schleswig Holstein University
   Hospital; University of Munster; Ruprecht Karls University Heidelberg
RP Rolke, R (corresponding author), Rhein Westfal TH Aachen, Med Fac, Dept Palliat Med, Pauwelsstr 30, D-52074 Aachen, Germany.
EM rrolke@ukaachen.de
RI Lampert, Angelika/F-7198-2010; Rolke, Roman/C-9042-2014; Vollert,
   Jan/AAJ-7461-2020; Schulz, Jörg/D-9786-2012
OI Rolke, Roman/0000-0002-7370-8574; Vollert, Jan/0000-0003-0733-5201;
   Zanella, Martina/0000-0002-9501-7854
FU Interdisciplinary Centre for Clinical Research within the Faculty of
   Medicine at the RWTH Aachen University [TN1-1/IA 532001, TN1-6/IA
   532006, IZKF TN1-9/IA 532009]; BMBF consortium Bio2Treat (German Federal
   Ministry of Education and Research/Bundesministerium fur Bildung und
   Forschung, BMBF) [13 GW0334B]
FX A. Lampert, M. F. Dohrn, and R. Rolke are supported by a grant from the
   Interdisciplinary Centre for Clinical Research within the Faculty of
   Medicine at the RWTH Aachen University (TN1-1/IA 532001, TN1-6/IA
   532006, IZKF TN1-9/IA 532009). A. Lampert and R. Rolke are funded by the
   BMBF consortium Bio2Treat (German Federal Ministry of Education and
   Research/Bundesministerium fur Bildung und Forschung, BMBF, "Chronische
   Schmerzen-Innovative medizintechnische Losungen zur Verbesserung von
   Pravention, Diagnostik und Therapie," contract number 13 GW0334B).
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NR 49
TC 10
Z9 10
U1 0
U2 9
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0304-3959
EI 1872-6623
J9 PAIN
JI Pain
PD SEP
PY 2022
VL 163
IS 9
BP 1800
EP 1811
DI 10.1097/j.pain.0000000000002580
PG 12
WC Anesthesiology; Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Anesthesiology; Neurosciences & Neurology
GA 3V9CJ
UT WOS:000841955900027
PM 35239546
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Fan, XD
   Wan, LL
   Duan, M
   Lu, S
AF Fan, Xiao-Di
   Wan, Lan-Lan
   Duan, Man
   Lu, Shan
TI HDAC11 deletion reduces fructose-induced cardiac dyslipidemia, apoptosis
   and inflammation by attenuating oxidative stress injury
SO BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
LA English
DT Article
DE HDAC11; Diabetic cardiac injury; Dyslipidemia; Apoptosis and
   inflammation; ROS
ID FATTY LIVER-DISEASE; DIABETIC CARDIOMYOPATHY; HISTONE DEACETYLASES;
   LIPID-ACCUMULATION; METABOLIC SYNDROME; HEART; OBESITY; ROLES; PROTECTS;
   IMPACT
AB Diabetes mellitus (DM) is a risk factor for abnormal heart development, but the molecular mechanism remains obscure. Histone deacetylase 11 (HDAC11), the most recently identified histone deacetylase, is the sole member of class IV HDACs. However, its role in diabetic cardiac injury is still poorly understood. In the present study, we attempted to explore the effects of HDAC11 on fructose (Fru)-induced cardiac injury using the wild type (HDAC11(+/+)) and knockout (HDAC11(-/-)) mice. The results indicated that HDAC11 was significantly expressed in human and mouse diabetic heart failure (DHF) hearts. HDAC11(-/-) reduced the body weight, inguinal fat-pad mass, and elevated blood pressure in Fru-fed mice. Compared to HDAC11(+/+)/Fru group, cardiac function was significantly improved in HDAC11(-/-)/Fru mice. HDAC11(-/-)/Fru mice exhibited reduced cardiac triacylglycerol (TG), total cholesterol (TC) and free fatty acid (FFA) levels, along with decreased mRNA levels of lipid synthesis-, lipid storage- and lipid oxidation-associated genes. In addition, HDAC11 attenuated apoptosis, oxidative stress and inflammation in the heart of Fru-fed mice, as evidenced by the reduced cleavage of Caspase-3, nicotinamide adenine dinucleotide phosphate (NADPH), and xanthine oxidase (XOD) activity, enhanced superoxide dismutase (SOD) activity, as well as the decreased interleukin 1 beta (IL-1 beta and tumor necrosis factor-alpha (TNF-alpha) levels, which was accompanied with down-regulated p-NF-kappa B. The results above were verified in Fru-treated primary cardiomyocytes isolated from HDAC11(+/+) or HDAC11(-/-) mice. Intriguingly, suppressing the expressions of anti-oxidants using zinc protoporphyrin (ZnPP) or siNrf-2 siRNA markedly abolished the results that HDAC11 suppression -induced reduction of apoptosis, reactive oxygen species (ROS) production, inflammation, as well as the improvement of dyslipidemia in Fru-incubated primary cardiomyocytes. Thus, ROS production was responsible for HDAC11-modulated diabetic heart injury. These findings suggested that suppressing HDAC11 has therapeutic potential for treating diabetes mellitus-associated cardiac injury. (C) 2018 Published by Elsevier Inc.
C1 [Fan, Xiao-Di; Lu, Shan] Jilin Univ, China Japan Union Hosp, Dept Anesthesiol, 126 Xiantai St, Changchun 130033, Jilin, Peoples R China.
   [Wan, Lan-Lan] Jilin Univ, Hosp 2, Dept Anesthesiol, 218 Ziqiang St, Changchun 130041, Jilin, Peoples R China.
   [Duan, Man] Jilin Univ, China Japan Union Hosp, Dept Vasc Surg, 126 Xiantai St, Changchun 130033, Jilin, Peoples R China.
C3 Jilin University; Jilin University; Jilin University
RP Lu, S (corresponding author), Jilin Univ, China Japan Union Hosp, Dept Anesthesiol, 126 Xiantai St, Changchun 130033, Jilin, Peoples R China.
EM lushandoa@foxmail.com
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NR 32
TC 36
Z9 39
U1 0
U2 20
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0006-291X
EI 1090-2104
J9 BIOCHEM BIOPH RES CO
JI Biochem. Biophys. Res. Commun.
PD SEP 5
PY 2018
VL 503
IS 2
BP 444
EP 451
DI 10.1016/j.bbrc.2018.04.090
PG 8
WC Biochemistry & Molecular Biology; Biophysics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics
GA GR5VY
UT WOS:000442711200008
PM 29655790
DA 2025-06-11
ER

PT J
AU Lee, K
   Kang, I
   Mortimer, JE
   Sattler, F
   Mack, WJ
   Fitzsimons, LA
   Salem, G
   Dieli-Conwright, CM
AF Lee, Kyuwan
   Kang, Irene
   Mortimer, Joanne E.
   Sattler, Fred
   Mack, Wendy J.
   Fitzsimons, Lindsey Avery
   Salem, George
   Dieli-Conwright, Christina M.
TI Effects of high-intensity interval training on vascular function in
   breast cancer survivors undergoing anthracycline chemotherapy: design of
   a pilot study
SO BMJ OPEN
LA English
DT Article
ID FLOW-MEDIATED DILATION; OXIDATIVE STRESS; AEROBIC EXERCISE;
   HEART-FAILURE; ENDOTHELIAL FUNCTION; MATRIX METALLOPROTEINASES;
   CARDIOVASCULAR-DISEASE; RESISTANCE EXERCISE; METABOLIC SYNDROME;
   PHYSICAL-EXERCISE
AB Introduction Cardiovascular disease (CVD) mortality is higher among breast cancer survivors (BCS) who receive chemotherapy compared with those not receiving chemotherapy. Anthracycline chemotherapy is of particular concern due to anthracycline-related impairment of vascular endothelial cells and dysregulation of the extracellular matrix. One strategy proven to offset these impairments is a form of exercise known as high-intensity interval training (HIIT). HIIT improves endothelial function in non-cancer populations by decreasing oxidative stress, the main contributor to anthracycline-induced vascular dysfunction. The purpose of this pilot study is to assess the feasibility of an 8-week HIIT, as well as the HIIT effects on endothelial function and extracellular matrix remodelling, in BCS undergoing anthracycline chemotherapy.
   Methods and analysis Thirty BCS are randomised to either HIIT, an 8-week HIIT intervention occurring three times per week (seven alternating bouts of 90% of peak power output followed by 10% peak power output), or delayed group (DEL). Feasibility of HIIT is assessed by (1) the percentage of completed exercise sessions and (2) the number of minutes of exercise completed over the course of the study. Vascular function is assessed using brachial artery flow-mediated dilation and carotid intima media thickness. Extracellular matrix remodelling is assessed by the level of matrix metalloproteinases in the plasma. A repeated-measures analysis of covariance model will be performed with group (HIIT and DEL group) and time (pre/post assessment) as independent factors. We hypothesise that HIT will be feasible in BCS undergoing anthracycline chemotherapy, and that HIIT will improve endothelial function and extracellular matrix remodelling, compared with the DEL group. Success of this study will provide evidence of feasibility and efficacy to support a larger definitive trial which will impact cancer survivorship by decreasing anthracycline-induced vascular dysfunction, thereby benefiting cardiovascular markers that are related to CVD risk.
   Ethics and dissemination This trial was approved by the University of Southern California Institutional Review Board (HS-15-00227).
C1 [Lee, Kyuwan; Sattler, Fred; Salem, George; Dieli-Conwright, Christina M.] USC, Ostrow Sch Dent, Div Biokinesiol & Phys Therapy, Los Angeles, CA 90007 USA.
   [Kang, Irene; Sattler, Fred; Dieli-Conwright, Christina M.] USC, Dept Med, Los Angeles, CA 90007 USA.
   [Mortimer, Joanne E.] City Hope Comprehens Canc Ctr, Div Med Oncol & Expt Therapeut, Duarte, CA USA.
   [Mack, Wendy J.] USC, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90033 USA.
   [Fitzsimons, Lindsey Avery] Univ Maine, Grad Sch Biomed Sci & Engn, Orono, ME USA.
C3 University of Southern California; University of Southern California;
   City of Hope; University of Southern California; University of Southern
   California Keck Hospital; University of Maine System; University of
   Maine Orono
RP Dieli-Conwright, CM (corresponding author), USC, Ostrow Sch Dent, Div Biokinesiol & Phys Therapy, Los Angeles, CA 90007 USA.; Dieli-Conwright, CM (corresponding author), USC, Dept Med, Los Angeles, CA 90007 USA.
EM cdieli@usc.edu
RI Fitzsimons, Lindsey/KLY-2778-2024
OI Fitzsimons, Lindsey/0000-0002-1949-6849; Kang, Irene/0000-0002-9472-3853
FU National Center for Advancing Translational Science (NCATS) of the US
   National Institutes of Health [UL1TR001855]
FX This work was supported by grant UL1TR001855 from the National Center
   for Advancing Translational Science (NCATS) of the US National
   Institutes of Health.
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NR 64
TC 11
Z9 11
U1 2
U2 12
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2044-6055
J9 BMJ OPEN
JI BMJ Open
PD JUN
PY 2018
VL 8
IS 6
AR e022622
DI 10.1136/bmjopen-2018-022622
PG 9
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA GR8AH
UT WOS:000442924700090
PM 29961039
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Yildiz, A
   Yilmaz, R
   Demirbag, R
   Gur, M
   Bas, MM
   Erel, O
AF Yildiz, Ali
   Yilmaz, Remzi
   Demirbag, Recep
   Gur, Mustafa
   Bas, Mehmet Memduh
   Erel, Ozcan
TI Association of serum uric-acid level and coronary blood flow
SO CORONARY ARTERY DISEASE
LA English
DT Article
DE atherosclerosis; coronary microvasculature; endothelial; dysfunction;
   slow coronary flow; vascular tonus
ID ENDOTHELIAL FUNCTION; NITRIC-OXIDE; CARDIOVASCULAR-DISEASE; METABOLIC
   SYNDROME; OXIDATIVE STRESS; XANTHINE-OXIDASE; FRAME COUNT; ALLOPURINOL;
   ATHEROSCLEROSIS; HYPERURICEMIA
AB Objectives Slow coronary flow (SCF) has long since been identified and endothelial dysfunction and atherosclerosis of the epicardial coronary arteries and microvasculature are reported to be associated with SCF. Serum uric acid is an independent biochemical marker of atherosclerosis, oxidative stress and endothelial dysfunction. Consequently, we aimed to investigate the association between coronary blood flow and serum uric acid level by means of thrombolysis in myocardial infarction frame count (TFC) and other laboratory parameters, in patients with SCF compared with control participants.
   Methods Sixty-four patients with SCF and 369 control participants with normal coronary flow were studied after quantifying coronary blood flow according to TFC. Serum uric acid levels were determined using commercially available assay kits. The association between TFC and serum uric acid level and other clinical and laboratory parameters were evaluated.
   Results Statistically significant differences were present between SCF and control groups with respect to serum uric acid, and hemoglobin levels, heart rate, cigarette smoking and sex (P < 0.05 for all). The mean TFC was significantly correlated with serum uric acid, urea, creatinine, high-density lipoprotein-cholesterol and hemoglobin levels, platelet count, male gender, cigarette smoking, heart rate and systolic blood pressure (P < 0.05 for all). Serum uric acid level (chi(2) =22.86, beta=0.54, P < 0.001), heart rate (chi(2) = 7.42, beta = -0.034, P < 0.032) and cigarette smoking (chi(2) = 12.343, beta=0.969, P=0.025) were independent predictors of SCF, whereas serum uric acid level was the only independent predictor of the mean TFC (beta=0.298, P < 0.001).
   Conclusions These findings have shown that serum uric acid level is significantly associated with coronary blood flow and that elevated uric acid might be an independent predictor for the presence of SCF. Coron Artery Dis 18:607-613 (c) 2007 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
C1 Harran Univ, Sch Med, Dept Cardiol, Sanliurfa, Turkey.
   Harran Univ, Sch Med, Dept Clin Biochem, Sanliurfa, Turkey.
C3 Harran University; Harran University
RP Yildiz, A (corresponding author), PK 112, Sanliurfa, Turkey.
EM ghcayildiz@yahoo.com
RI Demirbag, Recep/Z-2369-2019; EREL, Ozcan/U-1008-2019
OI Demirbag, Recep/0000-0001-7831-2715
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NR 36
TC 36
Z9 46
U1 0
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0954-6928
EI 1473-5830
J9 CORONARY ARTERY DIS
JI Coronary Artery Dis.
PD DEC
PY 2007
VL 18
IS 8
BP 607
EP 613
DI 10.1097/MCA.0b013e3282f0a2a7
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 236AR
UT WOS:000251275900003
PM 18004110
DA 2025-06-11
ER

PT J
AU Hamzavi, SF
   Vahed, IE
   Shams, AS
   Nozari, F
   Latava, BG
   Mardukhi, S
   Sabaghi, B
   Hosseini, ZS
   Babak, ZMSE
   Ahrari, S
   Keshavarzian, A
   Rahmanian, M
AF Hamzavi, Seyedeh Fatemeh
   Vahed, Iman Elahi
   Shams, Ali Samadi
   Nozari, Fateme
   Latava, Baroukh Gamzeh
   Mardukhi, Saman
   Sabaghi, Behnoosh
   Hosseini, Zakieh Sadat
   Babak, Zohre Masoumi Shahr-e
   Ahrari, Sahar
   Keshavarzian, Ali
   Rahmanian, Mohammad
TI Association between polychlorinated biphenyls and hypertension risk: a
   systematic review and meta-analysis
SO FRONTIERS IN CARDIOVASCULAR MEDICINE
LA English
DT Review
DE polychlorinated biphenyls; persistent organic pollutants; hypertension;
   high blood pressure; cardiovascular diseases
ID PERSISTENT ORGANIC POLLUTANTS; ORGANOCHLORINE COMPOUNDS;
   NATIONAL-HEALTH; BLOOD-PRESSURE; SERUM CONCENTRATIONS; METABOLIC
   SYNDROME; OXIDATIVE STRESS; PCBS; POPULATION; EXPOSURE
AB Background and Aim: Hypertension (HTN) is a widespread global health challenge, and its increasing prevalence is attributed to individual and environmental risk factors. Persistent organic pollutants (POPs), especially polychlorinated biphenyls (PCBs), contribute to cardiovascular risk by accumulating in fatty tissues, which leads to oxidative stress and vascular inflammation. This review and meta-analysis aimed to investigate the association between PCB exposure and hypertension. Methods: Adhering to the PRISMA 2020 guidelines, data sources such as PubMed, Scopus, Web of Science, and Google Scholar were systematically searched up to July 2024 to find observational studies on the link between PCBs and hypertension risk. Studies were reviewed and chosen according to established inclusion and exclusion criteria, focusing on observational studies examining PCB exposure and hypertension risk. Independent reviewers conducted data extraction, and the quality of studies was evaluated using the JBI critical appraisal tool. A meta-analysis with a random-effects model was conducted to determine combined odds ratios (ORs) for hypertension linked to total PCB exposure and specific PCB types. Results: Of the 494 records identified, 21 studies met the inclusion criteria, comprising 5 cohort studies, 15 cross-sectional studies, and one case-control study, totaling 51,514 participants. Exposure to total PCBs correlated with an elevated risk of hypertension (OR = 1.78, 95% CI: 1.30-2.44). Dioxin-like PCBs were also associated with a heightened risk (OR = 1.54, 95% CI: 1.24-1.90), while non-dioxin-like PCBs were not significantly linked (OR = 1.16, 95% CI: 0.81-1.66). Among individual congeners, PCB-74, PCB-118, PCB-105, and PCB-153 were significantly related to higher hypertension risk. Conclusion: These findings indicate a positive correlation between PCB exposure and hypertension, particularly with dioxin-like PCBs and certain PCB congeners. Additional research is necessary to clarify the mechanisms involved and to promote measures for reducing PCB exposure, particularly in high-risk populations. Systematic Review Registration: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42024595223, PROSPERO (CRD42024595223).
C1 [Hamzavi, Seyedeh Fatemeh; Rahmanian, Mohammad] Shahid Beheshti Univ Med Sci, Student Res Comm, Sch Med, Tehran, Iran.
   [Vahed, Iman Elahi; Babak, Zohre Masoumi Shahr-e] Shahid Beheshti Univ Med Sci, Sch Med, Tehran, Iran.
   [Shams, Ali Samadi] Islamic Azad Univ, Dept Cardiol, Tabriz, Iran.
   [Nozari, Fateme] Univ Tehran Med Sci, Student Res Comm, Tehran, Iran.
   [Latava, Baroukh Gamzeh] Hormozgan Univ Med Sci, Sch Med, Bandar Abbas, Hormozgan, Iran.
   [Mardukhi, Saman] Shiraz Univ Med Sci, Sch Publ Hlth, Dept Occupat Hlth & Safety Engn, Shiraz, Iran.
   [Sabaghi, Behnoosh] Isfahan Univ Med Sci, Sch Med, Esfahan, Iran.
   [Hosseini, Zakieh Sadat] Neyshabur Univ Med Sci, Fac Hlth & Paramed, Dept Publ Hlth, Neyshabur, Iran.
   [Ahrari, Sahar] Islamic Azad Univ, Pharmaceut Sci Res Ctr, Tehran Med Sci, Tehran, Iran.
   [Keshavarzian, Ali] Golestan Univ Med Sci, Sch Med, Gorgan, Golestan, Iran.
C3 Shahid Beheshti University Medical Sciences; Shahid Beheshti University
   Medical Sciences; Islamic Azad University; Tehran University of Medical
   Sciences; Shiraz University of Medical Science; Isfahan University of
   Medical Sciences; Islamic Azad University; Tehran University of Medical
   Sciences; Golestan University of Medical Sciences
RP Rahmanian, M (corresponding author), Shahid Beheshti Univ Med Sci, Student Res Comm, Sch Med, Tehran, Iran.
EM mmdrahmanian@gmail.com
RI SamadiShams, Ali/LWI-9983-2024
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NR 75
TC 0
Z9 0
U1 1
U2 1
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2297-055X
J9 FRONT CARDIOVASC MED
JI Front. Cardiovasc. Med.
PD APR 17
PY 2025
VL 12
AR 1529431
DI 10.3389/fcvm.2025.1529431
PG 14
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 2CU4T
UT WOS:001479583000001
PM 40313580
DA 2025-06-11
ER

PT J
AU Siroká, M
   Franco, C
   Gul'asová, Z
   Hertelyová, Z
   Tomecková, V
   Rodella, LF
   Rezzani, R
AF Siroka, Monika
   Franco, Caterina
   Gul'asova, Zuzana
   Hertelyova, Zdenka
   Tomeckova, Vladimira
   Rodella, Luigi F.
   Rezzani, Rita
TI Nuclear factor-kB and nitric oxide synthases in red blood cells: Good or
   bad in obesity? A preliminary study
SO EUROPEAN JOURNAL OF HISTOCHEMISTRY
LA English
DT Article
DE Metabolic syndrome; erythrocytes; inflammation; oxidative stress;
   therapeutic strategies
ID POLYUNSATURATED FATTY-ACIDS; NF-KAPPA-B; ERYTHROCYTE-MEMBRANES;
   INSULIN-RESISTANCE; GENE-EXPRESSION; FISH-OIL; INFLAMMATION; INOS;
   OVERWEIGHT; PLASMA
AB Emerging evidence suggests that red blood cells (RBCs) are involved in many functions essential for life. Nuclear factor-kB (NF-kB), nitric oxide synthases (inducible nitric oxide synthase - iNOS, endothelial nitric oxide synthase - eNOS) and interleukin-1 beta (IL-beta) are all proteins that have been identified in RBCs. In nucleated cells, such as white blood cells (WBCs), these proteins have well investigated roles, linked to stress and inflammation. It is not the same in erythrocytes. For this reason, we considered obese patients for studying the morphology of RBCs. We studied a possible correlation between their morphological changes and several protein expressions. Moreover, we compared the results about the aforementioned proteins and antioxidant markers with those obtained in WBCs from healthy and obese patients before and after omega-3 polyunsaturated fatty acid supplementation. This latter scientific point is important in order to determine whether there are differences in the expression of nucleated and anucleated cells. The morphology of RBCs changed in obese patients, but it is significantly restored after six weeks of supplementation. The expression of antioxidant enzymes changed in RBCs and WBCs in obesity but all proteins restore their positivity after supplementation. We found that: the presence of NP-kB, antioxidant enzymes and eNOS in healthy RBCs could indicate a role of these proteins as regulators of cellular metabolism; obese WBCs showed a higher NF-kB, iNOS and IL-1 beta positivity, whereas eNOS presence did not significantly change in these cells. We tried to explain the different positivity of NF-kB, proposing a dual role for this protein, as prolifespan and as proinflammatory processes, depending on examined cells. In conclusion, we have considered the literature that focuses on the omega6/omega-3 ratio. The ratio changed from the past, especially in people whose diet is strongly westernized worsening the state of health of the patient and leading to an higher incidence of obesity. Our study hypothesizes that the supplementation could help to restore the correct ratio.
C1 [Siroka, Monika; Tomeckova, Vladimira] Safarik Univ, Fac Med, Dept Med & Clin Biochem, Kosice, Slovakia.
   [Franco, Caterina; Rodella, Luigi F.; Rezzani, Rita] Univ Brescia, Dept Clin & Expt Sci, Anat & Physiopathol Div, Piazza Mercato 15, I-25121 Brescia, Italy.
   [Gul'asova, Zuzana; Hertelyova, Zdenka] Safarik Univ, Fac Med, Dept Expt Med, Kosice, Slovakia.
   [Rodella, Luigi F.; Rezzani, Rita] Univ Brescia, Interdipartimental Univ Ctr Res Adopt & Regenerat, Brescia, Italy.
C3 University of Pavol Jozef Safarik Kosice; University of Brescia;
   University of Pavol Jozef Safarik Kosice; University of Brescia
RP Rezzani, R (corresponding author), Univ Brescia, Dept Clin & Expt Sci, Anat & Physiopathol Div, Piazza Mercato 15, I-25121 Brescia, Italy.
EM rita.rezzani@unibs.it
RI Franco, Caterina/AAU-2520-2021
OI Franco, Caterina/0000-0002-3973-0436; Hertelyova,
   Zdenka/0000-0003-1552-7115; Rezzani, Rita/0000-0002-7515-5846;
   Tomeckova, Vladimira/0000-0002-5701-5719; Gulasova,
   Zuzana/0000-0002-8206-8476
FU University of Brescia, Italy; VEGA of the Ministry for Education,
   Science, Research and Sport of the Slovak Republic [VEGA 1/0584/16,
   APVV-16-0176]; APVV grant of the Ministry for Education, Science,
   Research and Sport of the Slovak Republic [VEGA 1/0584/16,
   APVV-16-0176]; Operational Program Research and Innovation for the
   project: Bioactive substances to promote health and prevent chronic
   diseases - European Regional Development Fund [PROBIO-3: NFP313010T651]
FX This work was supported by 60% grant (University of Brescia, Italy) and
   by VEGA and APVV grant (VEGA 1/0584/16; APVV-16-0176) of the Ministry
   for Education, Science, Research and Sport of the Slovak Republic.
   Moreover, this publication has been produced thanks to the support of
   the Operational Program Research and Innovation for the project:
   Bioactive substances to promote health and prevent chronic diseases
   (PROBIO-3: NFP313010T651), financed by the European Regional Development
   Fund.
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NR 97
TC 9
Z9 9
U1 0
U2 4
PU PAGEPRESS PUBL
PI PAVIA
PA MEDITGROUP, VIA G BELLI, 4, PAVIA, 27100, ITALY
SN 1121-760X
EI 2038-8306
J9 EUR J HISTOCHEM
JI Eur. J. Histochem.
PY 2020
VL 64
IS 1
BP 18
EP 31
AR 3081
DI 10.4081/ejh.2020.3081
PG 14
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA KW5QJ
UT WOS:000521219500003
PM 31988533
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Singh, V
   Jain, M
   Misra, A
   Khanna, V
   Prakash, P
   Malasoni, R
   Dwivedi, AK
   Dikshit, M
   Barthwal, MK
AF Singh, Vishal
   Jain, Manish
   Misra, Ankita
   Khanna, Vivek
   Prakash, Prem
   Malasoni, Richa
   Dwivedi, Anil Kumar
   Dikshit, Madhu
   Barthwal, Manoj Kumar
TI Curcuma oil ameliorates insulin resistance & associated
   thrombotic complications in hamster & rat
SO INDIAN JOURNAL OF MEDICAL RESEARCH
LA English
DT Article
DE Curcuma oil; hamster; hyperinsulinaemia; platelets; SREBP-1c
ID METABOLIC SYNDROME; HEPATIC STEATOSIS; ANIMAL-MODEL; HIGH-FAT; FRUCTOSE;
   GLUCONEOGENESIS; HYPERLIPIDEMIA; KINASE; LONGA; GAMMA
AB Background & objectives: Curcuma oil (C. oil) isolated from turmeric (Curcuma longa L.) has been shown to have neuro-protective, anti-cancer, antioxidant and anti-hyperlipidaemic effects in experimental animal models. However, its effect in insulin resistant animals remains unclear. The present study was carried out to investigate the disease modifying potential and underlying mechanisms of the C. oil in animal models of diet induced insulin resistance and associated thrombotic complications.
   Methods: Male Golden Syrian hamsters on high fructose diet (HFr) for 12 wk were treated orally with vehicle, fenofibrate (30 mg/kg) or C. oil (300 mg/kg) in the last four weeks. Wistar rats fed HFr for 12 wk were treated orally with C. oil (300 mg/kg) in the last two weeks. To examine the protective effect of C. oil, blood glucose, serum insulin, platelet aggregation, thrombosis and inflammatory markers were assessed in these animals.
   Results: Animals fed with HFr diet for 12 wk demonstrated hyperlipidaemia, hyperglycaemia, hyperinsulinaemia, alteration in insulin sensitivity indices, increased lipid peroxidation, inflammation, endothelial dysfunction, platelet free radical generation, tyrosine phosphorylation, aggregation, adhesion and intravascular thrombosis. Curcuma oil treatment for the last four weeks in hamsters ameliorated HFr-induced hyperlipidaemia, hyperglycaemia, insulin resistance, oxidative stress, inflammation, endothelial dysfunction, platelet activation, and thrombosis. In HFr fed hamsters, the effect of C. oil at 300 mg/kg was comparable with the standard drug fenofibrate. Curcuma oil treatment in the last two weeks in rats ameliorated HFr-induced hyperglycaemia and hyperinsulinaemia by modulating hepatic expression of sterol regulatory element binding protein 1c (SREBP-1c), peroxisome proliferator-activated receptor-gamma co-activator 1 (PGC-1)alpha and PGC-1 beta genes known to be involved in lipid and glucose metabolism.
   Interpretation & conclusions: High fructose feeding to rats and hamsters led to the development of insulin resistance, hyperglycaemia, endothelial dysfunction and oxidative stress. C. oil prevented development of thrombotic complications associated with insulin resistance perhaps by modulating genes involved in lipid and glucose metabolism. Further studies are required to confirm these findings.
C1 [Singh, Vishal; Jain, Manish; Misra, Ankita; Khanna, Vivek; Prakash, Prem; Dikshit, Madhu; Barthwal, Manoj Kumar] CSIR, Cent Drug Res Inst, Div Pharmacol, Lucknow 226031, Uttar Pradesh, India.
   [Malasoni, Richa; Dwivedi, Anil Kumar] CSIR, Cent Drug Res Inst, Div Pharmaceut, Lucknow 226031, Uttar Pradesh, India.
C3 Council of Scientific & Industrial Research (CSIR) - India; CSIR -
   Central Drug Research Institute (CDRI); Council of Scientific &
   Industrial Research (CSIR) - India; CSIR - Central Drug Research
   Institute (CDRI)
RP Barthwal, MK (corresponding author), CSIR, Cent Drug Res Inst, Div Pharmacol, BS 10-1,Sect 10,Sitapur Rd, Lucknow 226031, Uttar Pradesh, India.
EM manojbarthwal@cdri.res.in
RI Jain, Manish/ABE-7652-2021; Singh, Vishal/N-1838-2019; Dwivedi,
   Anil/C-4684-2012; Prakash, Prem/AAI-1672-2020
OI Singh, Vishal/0000-0003-3577-1713; Jain, Manish/0000-0002-7263-9829;
   Prakash, Prem/0000-0001-9501-0065; Pandey, Ankita/0000-0001-8585-335X
FU CSIR-Central Drug Research Institute; CSIR Network Project [BSC0102,
   BSC0103]; Council of Scientific and Industrial Research (CSIR) New
   Delhi, India
FX Financial support from CSIR-Central Drug Research Institute and CSIR
   Network Project (BSC0102, BSC0103) to the last author (MKB) is
   acknowledged. Authors also acknowledge the Council of Scientific and
   Industrial Research (CSIR) New Delhi, India, for the award of research
   fellowships to VS, AM, VK, PP, and the Indian Council of Medical
   Research (ICMR), New Delhi, India, to MJ, and thank Dr MPS Negi from
   Biometry and Statistics Division, CSIR-Central Drug Research Institute
   for helping in the statistical analysis of the data. This is CDRI
   communication number 8614.
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NR 29
TC 12
Z9 15
U1 1
U2 10
PU MEDKNOW PUBLICATIONS & MEDIA PVT LTD
PI MUMBAI
PA B-9, KANARA BUSINESS CENTRE, OFF LINK RD, GHAKTOPAR-E, MUMBAI, 400075,
   INDIA
SN 0971-5916
J9 INDIAN J MED RES
JI Indian J. Med. Res.
PD JUN
PY 2015
VL 141
BP 823
EP 832
DI 10.4103/0971-5916.160719
PG 10
WC Immunology; Medicine, General & Internal; Medicine, Research &
   Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; General & Internal Medicine; Research & Experimental
   Medicine
GA CN4WO
UT WOS:000358431400012
PM 26205026
OA gold, Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Joseph, EK
   Green, PG
   Ferrari, LF
   Levine, JD
AF Joseph, E. K.
   Green, P. G.
   Ferrari, L. F.
   Levine, J. D.
TI HOMOCYSTEINE-INDUCED ATTENUATION OF VASCULAR ENDOTHELIUM-DEPENDENT
   HYPERALGESIA IN THE RAT
SO NEUROSCIENCE
LA English
DT Article
DE vascular pain; homocysteine; methionine endothelium; muscle pain
ID CARDIAC SYNDROME-X; MECHANICAL HYPERALGESIA; VIBRATION EXPOSURE;
   SHEAR-STRESS; FOLIC-ACID; DYSFUNCTION; HYPERHOMOCYSTEINEMIA; RECEPTORS;
   RELEASE; CELLS
AB We have recently demonstrated a role of the vascular endothelium in peripheral pain mechanism by disrupting endothelial cell function using intravascular administration of octoxynol-9, a non-selective membrane active agent. As an independent test of the role of endothelial cells in pain mechanisms, we evaluated the effect of homocysteine, an agent that damages endothelial cell function. Mechanical stimulus-induced enhancement of endothelin-1 hyperalgesia in the gastrocnemius muscle of the rat was first prevented then enhanced by intravenous administration of homocysteine, but was only inhibited by its precursor, methionine. Both homocysteine and methionine significantly attenuated mechanical hyperalgesia in two models of ergonomic muscle pain, induced by exposure to vibration, and by eccentric exercise, and cutaneous mechanical hyperalgesia in an ischemia-reperfusion injury model of Complex Regional Pain Syndrome type I, all previously shown responsive to octoxynol-9. This study provides independent support for a role of the endothelial cell in pain syndromes thought to have a vascular basis, and suggests that substances that are endothelial cell toxins can enhance vascular pain. (C) 2014 IBRO. Published by Elsevier Ltd. All rights reserved.
C1 Univ Calif San Francisco, Dept Med, Div Neurosci, San Francisco, CA 94143 USA.
   [Levine, J. D.] Univ Calif San Francisco, Dept Oral & Maxillofacial Surg, San Francisco, CA 94143 USA.
C3 University of California System; University of California San Francisco;
   University of California System; University of California San Francisco
RP Levine, JD (corresponding author), Univ Calif San Francisco, Dept Oral & Maxillofacial Surg, San Francisco, CA 94143 USA.
EM Jon.Levine@ucsf.edu
RI ; Green, Paul/C-5943-2011
OI Ferrari, Luiz/0000-0002-3831-6428; Levine, Jon/0000-0003-0681-5545;
   Green, Paul/0000-0001-7648-6826
FU NIH [NS085831]
FX This work was supported by NIH grant NS085831. The authors report no
   conflicts of interest.
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NR 47
TC 8
Z9 8
U1 0
U2 7
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4522
EI 1873-7544
J9 NEUROSCIENCE
JI Neuroscience
PD JAN 22
PY 2015
VL 284
BP 678
EP 684
DI 10.1016/j.neuroscience.2014.10.056
PG 7
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA AW4HZ
UT WOS:000346243100060
PM 25451284
OA Green Accepted, Green Published
DA 2025-06-11
ER

PT J
AU Liu, Q
   Chen, JZ
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   Song, LJ
AF Liu, Qiong
   Chen, Jianzhu
   Zeng, Anqi
   Song, Linjiang
TI Pharmacological functions of salidroside in renal diseases: facts and
   perspectives
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Review
DE salidroside; diabetic nephropathy; renal interstitial fibrosis; acute
   kidney injury; inflammation; renal cell carcinoma
ID ISCHEMIA-REPERFUSION INJURY; RENIN-ANGIOTENSIN SYSTEM; INDUCED OXIDATIVE
   STRESS; ACUTE KIDNEY INJURY; RHODIOLA-ROSEA-L.; NF-KAPPA-B;
   DIABETIC-NEPHROPATHY; SIGNALING PATHWAYS; PODOCYTE INJURY; HIGH GLUCOSE
AB Rhodiola rosea is a valuable functional medicinal plant widely utilized in China and other Asian countries for its anti-fatigue, anti-aging, and altitude sickness prevention properties. Salidroside, a most active constituent derived from Rhodiola rosea, exhibits potent antioxidative, hypoxia-resistant, anti-inflammatory, anticancer, and anti-aging effects that have garnered significant attention. The appreciation of the pharmacological role of salidroside has burgeoned over the last decade, making it a beneficial option for the prevention and treatment of multiple diseases, including atherosclerosis, Alzheimer's disease, Parkinson's disease, cardiovascular disease, and more. With its anti-aging and renoprotective effects, in parallel with the inhibition of oxidative stress and inflammation, salidroside holds promise as a potential therapeutic agent for kidney damage. This article provides an overview of the microinflammatory state in kidney disease and discuss the current therapeutic strategies, with a particular focus on highlighting the recent advancements in utilizing salidroside for renal disease. The potential mechanisms of action of salidroside are primarily associated with the regulation of gene and protein expression in glomerular endothelial cells, podocytes, renal tubule cells, renal mesangial cells and renal cell carcinoma cell, including TNF-alpha, TGF-beta, IL-1 beta, IL-17A, IL-6, MCP-1, Bcl-2, VEGF, ECM protein, caspase-3, HIF-1 alpha, BIM, as well as the modulation of AMPK/SIRT1, Nrf2/HO-1, Sirt1/PGC-1 alpha, ROS/Src/Cav-1, Akt/GSK-3 beta, TXNIP-NLRP3, ERK1/2, TGF-beta 1/Smad2/3, PI3K/Akt, Wnt1/Wnt3a beta-catenin, TLR4/NF-kappa B, MAPK, JAK2/STAT3, SIRT1/Nrf2 pathways. To the best of our knowledge, this review is the first to comprehensively cover the protective effects of salidroside on diverse renal diseases, and suggests that salidroside has great potential to be developed as a drug for the prevention and treatment of metabolic syndrome, cardiovascular and cerebrovascular diseases and renal complications.
C1 [Liu, Qiong; Chen, Jianzhu; Song, Linjiang] Chengdu Univ Tradit Chinese Med, Sch Med & Life Sci, Chengdu, Sichuan, Peoples R China.
   [Zeng, Anqi] Sichuan Acad Chinese Med Sci, Sichuan Inst Translat Chinese Med, Translat Chinese Med Key Lab Sichuan Prov, Chengdu, Sichuan, Peoples R China.
C3 Chengdu University of Traditional Chinese Medicine
RP Song, LJ (corresponding author), Chengdu Univ Tradit Chinese Med, Sch Med & Life Sci, Chengdu, Sichuan, Peoples R China.; Zeng, AQ (corresponding author), Sichuan Acad Chinese Med Sci, Sichuan Inst Translat Chinese Med, Translat Chinese Med Key Lab Sichuan Prov, Chengdu, Sichuan, Peoples R China.
EM zeng6002aq@163.com; songlinjiang@cdutcm.edu.cn
OI Liu, Qiong/0009-0007-2664-3919
FU Xinglin project of Chengdu University of Traditional Chinese Medicine
   [ZKYY 2019, MPRC2021012]
FX The author(s) declare financial support was received for the research,
   authorship, and/or publication of this article. The work is supported by
   Xinglin project of Chengdu University of Traditional Chinese Medicine
   (ZKYY 2019, MPRC2021012).
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NR 188
TC 13
Z9 14
U1 14
U2 41
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD JAN 8
PY 2024
VL 14
AR 1309598
DI 10.3389/fphar.2023.1309598
PG 19
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA GL2C0
UT WOS:001152748200001
PM 38259279
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Li, AL
   Lian, L
   Chen, XN
   Cai, WH
   Fan, XB
   Fan, YJ
   Li, TT
   Xie, YY
   Zhang, JP
AF Li, Ao-lin
   Lian, Lu
   Chen, Xin-nong
   Cai, Wen-hui
   Fan, Xin-biao
   Fan, Ya-jie
   Li, Ting-ting
   Xie, Ying-yu
   Zhang, Jun-ping
TI The role of mitochondria in myocardial damage caused by energy
   metabolism disorders: From mechanisms to therapeutics
SO FREE RADICAL BIOLOGY AND MEDICINE
LA English
DT Review
DE Mitochondria; Energy metabolism; Myocardial damage; Mitochondrial
   quality control; Oxidative stress; Calcium homeostasis; Epigenetics;
   Therapy
ID FATTY-ACID OXIDATION; MUSCLE INSULIN-RESISTANCE; TYPE-2
   DIABETES-MELLITUS; HEART-FAILURE; LYSINE ACETYLATION; CARDIAC
   METABOLISM; INDUCED INJURY; STEM-CELL; OBESITY; MITOPHAGY
AB Myocardial damage is the most serious pathological consequence of cardiovascular diseases and an important reason for their high mortality. In recent years, because of the high prevalence of systemic energy metabolism disorders (e.g., obesity, diabetes mellitus, and metabolic syndrome), complications of myocardial damage caused by these disorders have attracted widespread attention. Energy metabolism disorders are independent of traditional injury-related risk factors, such as ischemia, hypoxia, trauma, and infection. An imbalance of myocardial metabolic flexibility and myocardial energy depletion are usually the initial changes of myocardial injury caused by energy metabolism disorders, and abnormal morphology and functional destruction of the mitochondria are their important features. Specifically, mitochondria are the centers of energy metabolism, and recent evidence has shown that decreased mitochondrial function, caused by an imbalance in mitochondrial quality control, may play a key role in myocardial injury caused by energy metabolism disorders. Under chronic energy stress, mitochondria undergo pathological fission, while mitophagy, mitochondrial fusion, and biogenesis are inhibited, and mitochondrial protein balance and transfer are disturbed, resulting in the accumulation of nonfunctional and damaged mitochondria. Consequently, damaged mitochondria lead to myocardial energy depletion and the accumulation of large amounts of reactive oxygen species, further aggravating the imbalance in mitochondrial quality control and forming a vicious cycle. In addition, impaired mitochondria coordinate calcium homeostasis imbalance, and epigenetic alterations participate in the pathogenesis of myocardial damage. These pathological changes induce rapid progression of myocardial damage, eventually leading to heart failure or sudden cardiac death. To intervene more specifically in the myocardial damage caused by metabolic disorders, we need to understand the specific role of mitochondria in this context in detail. Accordingly, promising therapeutic strategies have been proposed. We also summarize the existing therapeutic strategies to provide a reference for clinical treatment and developing new therapies.
C1 [Li, Ao-lin; Lian, Lu; Cai, Wen-hui; Fan, Xin-biao; Fan, Ya-jie; Li, Ting-ting; Zhang, Jun-ping] Tianjin Univ Tradit Chinese Med, Teaching Hosp 1, Tianjin 300183, Peoples R China.
   [Li, Ao-lin; Lian, Lu; Cai, Wen-hui; Fan, Xin-biao; Fan, Ya-jie; Li, Ting-ting] Natl Clin Res Ctr Chinese Med Acupuncture & Moxibu, Tianjin 300193, Peoples R China.
   [Li, Ao-lin; Lian, Lu; Cai, Wen-hui; Fan, Xin-biao; Fan, Ya-jie; Li, Ting-ting] Tianjin Univ Tradit Chinese Med, Tianjin 300193, Peoples R China.
   [Chen, Xin-nong] Tianjin First Cent Hosp, Dept Tradit Chinese Med, Tianjin 300190, Peoples R China.
   [Xie, Ying-yu] Tianjin Univ Tradit Chinese Med, Coll Tradit Chinese Med, Tianjin 300193, Peoples R China.
C3 Tianjin University of Traditional Chinese Medicine; Tianjin University
   of Traditional Chinese Medicine; Tianjin Medical University; Tianjin
   University of Traditional Chinese Medicine
RP Zhang, JP (corresponding author), Tianjin Univ Tradit Chinese Med, Teaching Hosp 1, Tianjin 300183, Peoples R China.; Xie, YY (corresponding author), Tianjin Univ Tradit Chinese Med, Coll Tradit Chinese Med, Tianjin 300193, Peoples R China.
EM xieyingyunn@163.com; tjzhtcm@163.com
RI Li, Aolin/HMP-3333-2023; Yang, Tingting/JAZ-1602-2023
FU National Natural Science Foundation of China [30672734, 82104721]; QI
   HUANG Scholars [203]; Tianjin Famous Traditional Chinese Medicine [732]
FX This work was supported by National Natural Science Foundation of China
   (No. 30672734, 82104721), QI HUANG Scholars (Junping Zhang) Special
   Funding (National Traditional Chinese Medicine People's Education
   Letter[2021] No. 203), Tianjin Famous Traditional Chinese Medicine
   (Junping Zhang) Inheritance Studio Special Funding (Jin Wei
   Zhong[2020]No.732).
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NR 218
TC 33
Z9 36
U1 3
U2 56
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0891-5849
EI 1873-4596
J9 FREE RADICAL BIO MED
JI Free Radic. Biol. Med.
PD NOV 1
PY 2023
VL 208
BP 236
EP 251
DI 10.1016/j.freeradbiomed.2023.08.009
EA AUG 2023
PG 16
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA Q7SS3
UT WOS:001059491100001
PM 37567516
DA 2025-06-11
ER

PT J
AU Song, CW
   Lv, W
   Li, YH
   Nie, P
   Lu, J
   Geng, YL
   Heng, Z
   Song, LH
AF Song, Chenwei
   Lv, Wei
   Li, Yahui
   Nie, Pan
   Lu, Jun
   Geng, Yanlou
   Heng, Zhang
   Song, Lihua
TI Alleviating the effect of quinoa and the underlying mechanism on hepatic
   steatosis in high-fat diet-fed rats
SO NUTRITION & METABOLISM
LA English
DT Article
DE Quinoa; Fatty liver; Oxidative stress; Lipid metabolism; Immune response
ID CHENOPODIUM-QUINOA; LIPOPROTEIN-LIPASE; GUT MICROBIOTA; LIVER-DISEASE;
   SEEDS; ANTIOXIDANT; WILLD.; SAPONINS; OBESITY; HUMANS
AB Background: Nonalcoholic fatty liver disease (NAFLD) is considered the hepatic component of metabolic syndrome and has attracted widespread attention due to its increased prevalence. Daily dietary management is an effective strategy for the prevention of NAFLD. Quinoa, a nutritious pseudocereal, is abundant in antioxidative bioactive phytochemicals. In the present study, the effects of different amounts of quinoa on the progression of NAFLD and the related molecular mechanism were investigated.
   Methods: Male SD rats were simultaneously administered a high fat diet (HF) and different amounts of quinoa (equivalent to 100 g/day and 300 g/day of human intake, respectively). After 12 weeks of the intervention, hepatic TG (triglyceride) and TC (total cholesterol) as well as serum antioxidative parameters were determined, and hematoxylin-eosin staining (H&E) staining was used to evaluate hepatic steatosis. Differential metabolites in serum and hepatic tissue were identified using UPLC-QTOF-MSE. The mRNA expression profile was investigated using RNA-Seq and further verified using real-time polymerase chain reaction (RT-PCR).
   Results: Low amounts of quinoa (equivalent to 100 g/d of human intake) effectively controlled the weight of rats fed a high-fat diet. In addition, quinoa effectively inhibited the increase in hepatic TG and TC levels, mitigated pathological injury, promoted the increase in SOD and GSH-Px activities, and decreased MDA levels. Nontarget metabolic profile analysis showed that quinoa regulated lipid metabolites in the circulation system and liver such as LysoPC and PC. RNA-Seq and RT-PCR verification revealed that a high amount of quinoa more effectively upregulated genes related to lipid metabolism [Apoa (apolipoprotein)5, Apoa4, Apoc2] and downregulated genes related to the immune response [lrf (interferon regulatory factor)5, Tlr6 (Toll-like receptor), Tlr10, Tlr11, Tlr12].
   Conclusion: Quinoa effectively prevented NAFLD by controlling body weight, mitigating oxidative stress, and regulating the lipid metabolic profile and the expression of genes related to lipid metabolism and the immune response.
C1 [Song, Chenwei; Nie, Pan; Song, Lihua] Shanghai Jiao Tong Univ, Sch Agr & Biol, Shanghai 200240, Peoples R China.
   [Lv, Wei; Geng, Yanlou] Natl Semiarid Agr Engn Technol Res Ctr, Shijiazhuang 050051, Hebei, Peoples R China.
   [Li, Yahui] State Adm Market Regulat, Ctr Food Evaluat, Beijing 100070, Peoples R China.
   [Lu, Jun; Heng, Zhang] Chinese Acad Sci, CAS Ctr Excellence Mol Plant Sci, Shanghai Ctr Plant Stress Biol, Shanghai 201602, Peoples R China.
C3 Shanghai Jiao Tong University; Chinese Academy of Sciences; Center for
   Excellence in Molecular Plant Sciences, CAS
RP Song, LH (corresponding author), Shanghai Jiao Tong Univ, Sch Agr & Biol, Shanghai 200240, Peoples R China.; Geng, YL (corresponding author), Natl Semiarid Agr Engn Technol Res Ctr, Shijiazhuang 050051, Hebei, Peoples R China.; Heng, Z (corresponding author), Chinese Acad Sci, CAS Ctr Excellence Mol Plant Sci, Shanghai Ctr Plant Stress Biol, Shanghai 201602, Peoples R China.
EM Kejizhiguang@163.com; hengzhang@psc.ac.cn; lihuas@sjtu.edu.cn
RI Zhang, Heng/JFS-3070-2023
OI Zhang, Heng/0000-0002-1541-3890
FU Key Technology Research and Development Program of Hebei Province (CN)
   [19227527D]; Shanghai Agriculture Applied Technology Development Program
   [2019-02-08-00-08-F01154]; Oceanic Interdisciplinary Program of Shanghai
   Jiao Tong University [SL2020ZD103]
FX This work was supported by grants from the Key Technology Research and
   Development Program of Hebei Province (CN) (19227527D), Shanghai
   Agriculture Applied Technology Development Program
   (2019-02-08-00-08-F01154) and Oceanic Interdisciplinary Program of
   Shanghai Jiao Tong University (SL2020ZD103).
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NR 51
TC 16
Z9 17
U1 0
U2 31
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1743-7075
J9 NUTR METAB
JI Nutr. Metab.
PD DEC 18
PY 2021
VL 18
IS 1
AR 106
DI 10.1186/s12986-021-00631-7
PG 16
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA XQ2LC
UT WOS:000731381100001
PM 34922572
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Jiang, HK
   Miao, Y
   Wang, YH
   Zhao, M
   Feng, ZH
   Yu, XJ
   Liu, JK
   Zang, WJ
AF Jiang, Hong-Ke
   Miao, Yi
   Wang, You-Hua
   Zhao, Mei
   Feng, Zhi-Hui
   Yu, Xiao-Jiang
   Liu, Jian-Kang
   Zang, Wei-Jin
TI Aerobic interval training protects against myocardial infarction-induced
   oxidative injury by enhancing antioxidase system and mitochondrial
   biosynthesis
SO CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
LA English
DT Article
DE aerobic interval training; anti-oxidase; mitochondrial biogenesis;
   myocardial infarction; phosphatidylinositol 3-kinase; Akt signalling;
   sirtuin 3
ID CONTINUOUS MODERATE EXERCISE; METABOLIC SYNDROME; HEART-FAILURE;
   POSTMYOCARDIAL INFARCTION; MESENTERIC-ARTERIES; PI3K/AKT PATHWAY;
   REACTIVE OXYGEN; STRESS; IMPROVES; SIRT3
AB Aerobic interval training (AIT) exerts beneficial effects on cardiovascular disease. However, its cardioprotective mechanisms are not fully understood. The aim of the present study was to evaluate AIT-mediated anti-oxidation by focusing on anti-oxidase and mitochondrial biogenesis in rats after myocardial infarction (MI). Sprague-Dawley rats were divided into three groups: (i) a sham-operated control (CON); (ii) an MI group; and (iii) an MI+AIT group. Myocardial microstructure and function, markers of oxidative stress, mitochondrial anti-oxidase, Phase II enzymes and mitochondrial biogenesis were assessed. In addition, levels of nuclear factor-erythroid 2-related factor (Nrf2) and phosphorylated (p-) AMP-activated protein kinase (AMPK) were determined. The anti-oxidative gene sirtuin 3 (SIRT3) and the prosurvival phosphatidylinositol-3 kinase (PI3-K)-protein kinase B (Akt) signalling cascade were also evaluated. Compared with CON, there was noticeable microstructure injury, cardiac dysfunction and oxidative damage in rats after MI. In addition, decreased mitochondrial anti-oxidase content, Phase II enzyme (except heme oxygenase-1) expression and mitochondrial biogenesis were observed in the post-MI rats as well as reduced protein levels of the regulators Nrf2 and p-AMPK and suppression of SIRT3 levels and PI3-K/Akt signalling. These detrimental modifications were considerably ameliorated by AIT, as evidenced by increases in anti-oxidase, mitochondrial biogenesis, Nrf2 and AMPK phosphorylation, as well as SIRT3 upregulation and PI3-K/Akt signalling activation. Moreover, PI3-K inhibitor-LY294002 (20mg/kg) treatment partly attenuated AIT-elicited increases in Nrf2 levels and AMPK phosphorylation. Based on these results, we conclude that AIT effectively alleviates MI-induced oxidative injury, which may be closely correlated with activation of the anti-oxidase system and mitochondrial biosynthesis. Increased SIRT3 expression and activation of PI3-K/Akt signalling may play key roles in AIT-mediated anti-oxidation. These results open up new avenues for exercise intervention therapies for MI patients.
C1 [Jiang, Hong-Ke; Miao, Yi; Wang, You-Hua; Zhao, Mei; Yu, Xiao-Jiang; Zang, Wei-Jin] Xi An Jiao Tong Univ, Coll Med, Dept Pharmacol, 76 Yanta West Rd, Xian 710061, Shaanxi, Peoples R China.
   [Jiang, Hong-Ke] Nan Yang Inst Technol, Dept Phys Educ, Nan Yang, Peoples R China.
   [Feng, Zhi-Hui; Liu, Jian-Kang] Xi An Jiao Tong Univ, Frontier Inst Sci & Technol, Sch Life Sci & Technol,Ctr Mitochondrial Biol & M, Key Lab Biomed Informat Engn,Minist Educ, Xian 710061, Shaanxi, Peoples R China.
C3 Xi'an Jiaotong University; Ministry of Education - China; Xi'an Jiaotong
   University
RP Zang, WJ (corresponding author), Xi An Jiao Tong Univ, Coll Med, Dept Pharmacol, 76 Yanta West Rd, Xian 710061, Shaanxi, Peoples R China.
EM zwj@mail.xjtu.edu.cn
RI zhao, mei/MTD-2215-2025; Wang, Xuejun/K-8874-2013; Feng,
   Zhihui/E-7408-2011
OI Feng, Zhihui/0000-0002-2448-6565
FU National Natural Science Foundation of China [81120108002, 30930105];
   Specialized Research Fund for the Doctoral Program of Higher Education
   [20130201130008]; CMB Distinguished Professorships Award
   [F510000/G16916404]; Natural Science Foundation of Shaanxi Province
   [2012JZ4001]
FX The authors are very grateful to Professor Zhen-Jun Tian, Dr Meng-Xin
   Cai and Xiu-Chao Shi from Shaanxi Normal University for assistance with
   the experiments. This work as supported by a Major International
   (Regional) Joint Research Project from the National Natural Science
   Foundation of China (No. 81120108002), Key Program of the National
   Natural Science Foundation of China (No. 30930105), the Specialized
   Research Fund for the Doctoral Program of Higher Education (No.
   20130201130008), a CMB Distinguished Professorships Award (No.
   F510000/G16916404) and the Natural Science Foundation of Shaanxi
   Province (No. 2012JZ4001).
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NR 56
TC 35
Z9 46
U1 0
U2 19
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0305-1870
EI 1440-1681
J9 CLIN EXP PHARMACOL P
JI Clin. Exp. Pharmacol. Physiol.
PD MAR
PY 2014
VL 41
IS 3
BP 192
EP 201
DI 10.1111/1440-1681.12211
PG 10
WC Pharmacology & Pharmacy; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Physiology
GA AD0LA
UT WOS:000332924300007
PM 24471974
DA 2025-06-11
ER

PT J
AU Nakhjavani, M
   Morteza, A
   Asgarani, F
   Khalilzadeh, O
   Ghazizadeh, Z
   Bathaie, SZ
   Esteghamati, A
AF Nakhjavani, Manouchehr
   Morteza, Afsaneh
   Asgarani, Firuzeh
   Khalilzadeh, Omid
   Ghazizadeh, Zaniar
   Bathaie, Seyede Zahra
   Esteghamati, Alireza
TI The dual behavior of heat shock protein 70 and asymmetric
   dimethylarginine in relation to serum CRP levels in type 2 diabetes
SO GENE
LA English
DT Article
DE HSP70; Heat-shock proteins; N,N-dimethylarginine (asymmetric
   dimethylarginine); C-reactive protein; Type 2 diabetes mellitus
ID NITRIC-OXIDE SYNTHASE; C-REACTIVE PROTEIN; HEAT-SHOCK PROTEINS;
   METABOLIC SYNDROME; HSP70 ACCUMULATION; KAPPA-B; DISEASE; STRESS;
   INFLAMMATION; EXPRESSION
AB Background: Experimental evidence suggests that heat shock proteins (HSP) and asymmetric dimethylarginine (ADMA) are induced in the state of chronic inflammation and stress conditions. They are both inhibitors of nitric oxide synthase (NOS). The aim of this study was to evaluate the correlation between ADMA and HSP70, in patients with type 2 diabetes with respect to serum levels of C reactive protein (CRP).
   Methods: We quantified serum HSP70, ADMA and CRP in 80 newly-diagnosed patients with type 2 diabetes plus 80 age-, sex and BMI-matched healthy controls. The patients and controls were also stratified into groups of high and low CRP levels (cut-point: 2.5 mg/ml).
   Results: Patients with type 2 diabetes had significantly higher serum HSP70 (0.52 [0.51-0.66] vs. 0.27 [0.26-0.36], p<0.001), ADMA (0.86 [0.81-0.92] vs. 0.72 [0.71-0.85], p<0.05) and CRP (2.9 [1.7-3.4] vs. 1.6[1.2-2.3], p<0.05) compared with healthy controls. Serum HSP70 and ADMA levels were significantly correlated in patients with high CRP levels (r =0.89, p <0.01), whereas there were no correlation in patients with low CRP (r = -0.37, p = 0.07) and controls. This correlation was significant (r = 0.77, p <0.001) in patients with high CRP and also in patients with low CRP levels (r = -0.51, p <0.05), after multiple adjustments for LDL and HDL levels.
   Discussion: We showed that, in a state of high inflammation; serum levels of ADMA parallel the HSP70 levels. However in low inflammation, they are negatively correlated. The duality in HSP70 and ADMA correlation may be related to the duality of NOS function in low and high CRP levels. (C) 2012 Elsevier B.V. All rights reserved.
C1 [Nakhjavani, Manouchehr; Morteza, Afsaneh; Asgarani, Firuzeh; Khalilzadeh, Omid; Ghazizadeh, Zaniar; Esteghamati, Alireza] Univ Tehran Med Sci, EMRC, Vali Asr Hosp, Tehran, Iran.
   [Bathaie, Seyede Zahra] Tarbiat Modares Univ, Dept Clin Biochem, Fac Med Sci, Tehran, Iran.
C3 Tehran University of Medical Sciences; Tarbiat Modares University
RP Nakhjavani, M (corresponding author), Univ Tehran Med Sci, EMRC, Vali Asr Hosp, POB 13145-784, Tehran, Iran.
EM nakhjavanim@tums.ac.ir; aafsaneh03@gmail.com; fasgarani@tums.ac.ir;
   o.khalilzadeh@gmail.com; xaniar@gmail.com; bathai_z@modares.ac.ir;
   esteghamati@tums.ac.ir
RI Nakhjavani, Manouchehr/J-3704-2019; Khalilzadeh, Omid/F-5769-2011;
   Bathaie, S. Zahra/D-4165-2009
OI Bathaie, S. Zahra/0000-0002-2529-045X
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NR 40
TC 27
Z9 28
U1 0
U2 6
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0378-1119
J9 GENE
JI Gene
PD APR 25
PY 2012
VL 498
IS 1
BP 107
EP 111
DI 10.1016/j.gene.2012.01.085
PG 5
WC Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Genetics & Heredity
GA 923AG
UT WOS:000302589800016
PM 22349026
DA 2025-06-11
ER

PT J
AU Bitorina, AV
   Oligschlaeger, Y
   Ding, LL
   Yadati, T
   Westheim, A
   Houben, T
   Vaes, RDW
   Damink, SWMO
   Theys, J
   Shiri-Sverdlov, R
AF Bitorina, Albert V.
   Oligschlaeger, Yvonne
   Ding, Lingling
   Yadati, Tulasi
   Westheim, Annemarie
   Houben, Tom
   Vaes, Rianne D. W.
   Damink, Steven W. M. Olde
   Theys, Jan
   Shiri-Sverdlov, Ronit
TI OxLDL as an Inducer of a Metabolic Shift in Cancer Cells
SO JOURNAL OF CANCER
LA English
DT Article
DE Pancreatic cancer cells; oxLDL; metabolic switch; HIF-1 alpha; autophagy
ID LOW-DENSITY-LIPOPROTEIN; OXIDIZED LDL; NONALCOHOLIC STEATOHEPATITIS;
   CARDIOVASCULAR-DISEASE; COLORECTAL-CANCER; OXIDATIVE STRESS; RISK;
   AUTOPHAGY; HYPOXIA; PROLIFERATION
AB Recent evidence established a link between disturbed lipid metabolism and increased risk for cancer. One of the most prominent features related to disturbed lipid metabolism is an increased production of oxidized low-density-lipoproteins (oxLDL), which results from elevated oxidative stress. OxLDL is known to have detrimental effects on healthy cells and plays a primary role in diseases related to the metabolic syndrome. Nevertheless, so far, the exact role of oxLDL in cancer cell metabolism is not yet known. To examine changes in metabolic profile induced by oxLDL, pancreatic KLM-1 cells were treated with oxLDL in a concentration- (25 or 50 mu g/ml) and/or time-dependent (4 hr or 8 hr) manner and the impact of oxLDL on oxygen consumption rates (OCR) as well as extracellular acidification rates (ECAR) was analyzed using Seahorse technology. Subsequently, to establish the link between oxLDL and glycolysis, stabilization of the master regulator hypoxia-inducible factor 1-alpha (HIF-1 alpha) was measured by means of Western blot. Furthermore, autophagic responses were assessed by measuring protein levels of the autophagosomal marker LC3B-II. Finally, the therapeutic potential of natural anti-oxLDL IgM antibodies in reversing these effects was tested. Incubation of KLM-1 cells with oxLDL shifted the energy balance towards a more glycolytic phenotype, which is an important hallmark of cancer cells. These data were supported by measurement of increased oxLDL-mediated HIF-1 alpha stabilization. In line, oxLDL incubation also increased the levels of LC3B-II, suggesting an elevated autophagic response. Importantly, antibodies against oxLDL were able to reverse these oxLDL-mediated metabolic effects. Our data provides a novel proof-of-concept that oxLDL induces a shift in energy balance. These data not only support a role for oxLDL in the progression of cancer but also suggest the possibility of targeting oxLDL as a therapeutic option in cancer.
C1 [Bitorina, Albert V.; Oligschlaeger, Yvonne; Yadati, Tulasi; Houben, Tom; Shiri-Sverdlov, Ronit] Maastricht Univ, Sch Nutr & Translat Res Metab NUTRIM, Dept Mol Genet, Maastricht, Netherlands.
   [Vaes, Rianne D. W.; Damink, Steven W. M. Olde] Maastricht Univ, Sch Nutr & Translat Res Metab NUTRIM, Dept Surg, Maastricht, Netherlands.
   [Westheim, Annemarie; Theys, Jan] Maastricht Univ, Sch Oncol & Dev Biol GROW, Dept Precis Med, Med Ctr, Maastricht, Netherlands.
C3 Maastricht University; Maastricht University; Maastricht University
RP Shiri-Sverdlov, R (corresponding author), Maastricht Univ, Sch Nutr & Translat Res Metab NUTRIM, Dept Mol Genet, Maastricht, Netherlands.; Theys, J (corresponding author), Maastricht Univ, Sch Oncol & Dev Biol GROW, Dept Precis Med, Med Ctr, Maastricht, Netherlands.
EM jan.theys@maastrichtuniversity.nl; r.sverdlov@maastrichtuniversity.nl
RI Olde Damink, Steven/U-7919-2019; Theys, Jan/K-6685-2015; Oligschlaeger,
   Yvonne/S-5654-2017; Shiri-Sverdlov, Ronit/E-5571-2017; Houben,
   Tom/T-1083-2017
OI Olde Damink, Steven/0000-0002-5202-9345; Theys, Jan/0000-0002-9718-8251;
   Shiri-Sverdlov, Ronit/0000-0002-6736-7814; Houben,
   Tom/0000-0002-0441-3166
FU CVON IN-CONTROL grant [CVON2012-03]; Dutch Organisation for Scientific
   Research (NWO) [016.126.327]; ASPASIA [015.008.043]; TKI-LSH
   [40-41200-98-9306]; Dutch Cancer Society (KWF) [10820]; VCK
   [Swu16.0057-VT]
FX This research was supported by the CVON IN-CONTROL grant (CVON2012-03),
   the Dutch Organisation for Scientific Research (NWO; Vidi grant no.
   016.126.327), ASPASIA (grant no. 015.008.043), TKI-LSH (grant no.
   40-41200-98-9306), Dutch Cancer Society (KWF grant no. 10820) and VCK
   (grant no. Swu16.0057-VT). The funding bodies had no role in the
   preparation of this manuscript or the decision to publish.
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NR 70
TC 5
Z9 5
U1 1
U2 5
PU IVYSPRING INT PUBL
PI LAKE HAVEN
PA PO BOX 4546, LAKE HAVEN, NSW 2263, AUSTRALIA
SN 1837-9664
J9 J CANCER
JI J. Cancer
PY 2021
VL 12
IS 19
BP 5817
EP 5824
DI 10.7150/jca.56307
PG 8
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA UE2KC
UT WOS:000687721900012
PM 34475995
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Nielsen, FH
AF Nielsen, Forrest H.
TI The Problematic Use of Dietary Reference Intakes to Assess Magnesium
   Status and Clinical Importance
SO BIOLOGICAL TRACE ELEMENT RESEARCH
LA English
DT Article
DE Magnesium; Dietary Reference Intakes; Status assessment; Requirement
   modifiers
ID SECTIONAL STATISTICAL-ANALYSES; CARDIOVASCULAR-DISEASE; CALCIUM INTAKE;
   INTESTINAL-ABSORPTION; METABOLIC SYNDROME; STATUS INDICATORS; SERUM
   MAGNESIUM; BONE TURNOVER; VITAMIN-E; WOMEN
AB Determination of the public health concern about magnesium (Mg) in health and disease has been confounded by the lack of a practical measure of status. This has resulted in a lack of consistency in associating Mg deficiency with specific pathological conditions. Some attempts at associating Mg with a chronic disease have used the Dietary Reference Intakes (DRIs) as a status assessment measure. Use of current DRIs for Mg is problematic because recent evidence suggests that they should be updated and based on body weight. An evidence-based suggested Estimated Average Requirement (EAR) and Recommended Dietary Allowance (RDA) for a 70-kg individual is 175 and 250 mg/day, respectively. However, numerous dietary and physiological factors can affect the need for Mg and thus affect the use of the current or suggested new DRIs to assess Mg status. Calcium intakes above normal requirements can decrease Mg balance and exacerbate signs of Mg deficiency. Mg deficiency apparently occurs often in obesity because of increased need to counteract the inflammatory stress induced by adipose tissue dysfunction. Deficiency in anti-oxidant nutrients such as vitamin E and selenium can exacerbate a response to low dietary Mg indicated by increased oxidative stress which can lead to chronic disease. Dietary modifiers of Mg absorption and excretion affect balance and thus the need for Mg. Factors decreasing Mg balance include low dietary protein and non-fermentable fiber, while factors that can increase balance include fructose and fermentable fiber and fructose-containing oligosaccharides. Use of the DRIs to assess the Mg status of a population or group needs to consider their physiological characteristics and dietary habits and be aware that the DRIs may need updating. The DRIs only can be considered a component of a toolbox that presently includes serum Mg concentration and the daily urinary Mg excretion to assess the Mg status of an individual.
OI Nielsen, Forrest/0000-0001-9557-4792
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NR 84
TC 21
Z9 24
U1 1
U2 10
PU HUMANA PRESS INC
PI TOTOWA
PA 999 RIVERVIEW DRIVE SUITE 208, TOTOWA, NJ 07512 USA
SN 0163-4984
EI 1559-0720
J9 BIOL TRACE ELEM RES
JI Biol. Trace Elem. Res.
PD MAR
PY 2019
VL 188
IS 1
BP 52
EP 59
DI 10.1007/s12011-018-1573-x
PG 8
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA HL3JN
UT WOS:000458610600007
PM 30484139
DA 2025-06-11
ER

PT J
AU Brand, S
   Amann, K
   Mandel, P
   Zimnol, A
   Schupp, N
AF Brand, Susanne
   Amann, Kerstin
   Mandel, Philipp
   Zimnol, Anna
   Schupp, Nicole
TI Oxidative DNA Damage in Kidneys and Heart of Hypertensive Mice Is
   Prevented by Blocking Angiotensin II and Aldosterone Receptors
SO PLOS ONE
LA English
DT Article
ID SMOOTH-MUSCLE-CELLS; KAPPA-B PATHWAY; BLOOD-PRESSURE; RENAL INJURY;
   ENDOTHELIAL DYSFUNCTION; XANTHINE OXIDOREDUCTASE; ENHANCED EXPRESSION;
   METABOLIC SYNDROME; HEME OXYGENASE-1; ORGAN DAMAGE
AB Introduction: Recently, we could show that angiotensin II, the reactive peptide of the blood pressure-regulating renin-angiotensin-aldosterone-system, causes the formation of reactive oxygen species and DNA damage in kidneys and hearts of hypertensive mice. To further investigate on the one hand the mechanism of DNA damage caused by angiotensin II, and on the other hand possible intervention strategies against end-organ damage, the effects of substances interfering with the renin-angiotensin-aldosterone-system on angiotensin II-induced genomic damage were studied.
   Methods: In C57BL/6-mice, hypertension was induced by infusion of 600 ng/kg . min angiotensin II. The animals were additionally treated with the angiotensin II type 1 receptor blocker candesartan, the mineralocorticoid receptor blocker eplerenone and the antioxidant tempol. DNA damage and the activation of transcription factors were studied by immunohistochemistry and protein expression analysis.
   Results: Administration of angiotensin II led to a significant increase of blood pressure, decreased only by candesartan. In kidneys and hearts of angiotensin II-treated animals, significant oxidative stress could be detected (1.5-fold over control). The redox-sensitive transcription factors Nrf2 and NF-kappa B were activated in the kidney by angiotensin II-treatment (4- nd 3-fold over control, respectively) and reduced by all interventions. In kidneys and hearts an increase of DNA damage (3-and 2-fold over control, respectively) and of DNA repair (3-fold over control) was found. These effects were ameliorated by all interventions in both organs. Consistently, candesartan and tempol were more effective than eplerenone.
   Conclusion: Angiotensin II-induced DNA damage is caused by angiotensin II type 1 receptor-mediated formation of oxidative stress in vivo. The angiotensin II-mediated physiological increase of aldosterone adds to the DNA-damaging effects. Blocking angiotensin II and mineralocorticoid receptors therefore has beneficial effects on end-organ damage independent of blood pressure normalization.
C1 [Brand, Susanne; Mandel, Philipp; Schupp, Nicole] Univ Wurzburg, Inst Pharmacol & Toxicol, D-97070 Wurzburg, Germany.
   [Zimnol, Anna; Schupp, Nicole] Univ Dusseldorf, Inst Toxicol, Dusseldorf, Germany.
   [Amann, Kerstin] Univ Erlangen Nurnberg, Dept Pathol, D-91054 Erlangen, Germany.
C3 University of Wurzburg; Heinrich Heine University Dusseldorf; University
   of Erlangen Nuremberg
RP Schupp, N (corresponding author), Univ Wurzburg, Inst Pharmacol & Toxicol, D-97070 Wurzburg, Germany.
EM nicole.schupp@toxi.uni-wuerzburg.de
FU German Cancer Aid [Deutsche Krebshilfe grant] [109328]; German Research
   Foundation [DFG] [SFB 423, Z2]
FX This work is supported by German Cancer Aid [Deutsche Krebshilfe grant
   #109328 to NS], http://www.krebshilfe.de, and German Research Foundation
   [DFG, SFB 423, Z2 to KA], http://www.dfg.de/. The funders had no role in
   study design, data collection and analysis, decision to publish, or
   preparation of the manuscript.
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NR 81
TC 22
Z9 24
U1 0
U2 11
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD DEC 31
PY 2014
VL 9
IS 12
AR e115715
DI 10.1371/journal.pone.0115715
PG 23
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA AX7UC
UT WOS:000347119100053
PM 25551569
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Asrih, M
   Gardier, S
   Papageorgiou, I
   Montessuit, C
AF Asrih, Mohamed
   Gardier, Stephany
   Papageorgiou, Irene
   Montessuit, Christophe
TI Dual effect of the heart-targeting cytokine cardiotrophin-1 on glucose
   transport in cardiomyocytes
SO JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
LA English
DT Article
DE Insulin resistance; Cardiotrophin-1; Glucose transport; Cardiomyocytes
ID ACTIVATED PROTEIN-KINASE; SOCS-3 MESSENGER-RNA; INSULIN-RESISTANCE;
   SKELETAL-MUSCLE; CARDIAC MYOCYTES; AS160 PHOSPHORYLATION; GLUT4
   TRANSLOCATION; IN-VITRO; EXPRESSION; HYPERTROPHY
AB Cardiotrophin-1 (CT-1) is a heart-targeting cytokine that is increased in the metabolic syndrome due to overexpression in the adipocytes. The effects of CT-1 on cardiomyocyte substrate metabolism remain unknown. We therefore determined the effects of CT-1 on basal and stimulated glucose transport in cardiomyocytes exposed to a low dose (1 nM) or a high dose (10 nM). Dose-response curves for insulin showed that 1 nM CT-1 reduced insulin responsiveness, while 10 nM CT-1 increased insulin responsiveness. In either condition insulin sensitivity was unaffected. Similarly 1 nM CT-1 reduced the stimulation of glucose transport in response to metabolic stress, induced by the mitochondrial poison oligomycin, while 10 nM CT-1 increased this response. Reduction of stimulated glucose transport by 1 nM CT-1 was associated with overexpression of SOCS-3, a protein known to hinder proximal insulin signaling, and increased phosphorylation of STAT5. In cardiomyocytes exposed to 1 nM CT-1 there was also reduced phosphorylation of Akt and AS160 in response to insulin, and of AMPK in response to oligomycin. Insulin-stimulated glucose transport and signaling were restored by inhibition of STAT5 activity. On the other hand in cardiomyocytes exposed to 10 nM CT-1 there was increased phosphorylation of the AS160 and Aid in response to insulin. Most importantly, basal and oligomycin-stimulated phosphorylation of AMPK was markedly increased in cardiomyocytes exposed to 10 nM CT-1. The enhancement of basal and stimulated-glucose transport was abolished in cardiomyocytes treated with the calmodulin-dependent kinase II (CaMKII) inhibitor KN93, and so was AMPK phosphorylation. This suggests that activation of CaMKII mediates activation of AMPK by a high dose of CT-1 independently of metabolic stress. Our results point to a role for CT-1 in the regulation of myocardial glucose metabolism and implicate entirely separate mechanisms in the inhibitory or stimulatory effects of CT-1 on glucose transport at low or high concentrations respectively. (c) 2012 Published by Elsevier Ltd.
C1 [Asrih, Mohamed; Gardier, Stephany; Papageorgiou, Irene; Montessuit, Christophe] Univ Hosp Geneva, Div Cardiol, CH-1211 Geneva 14, Switzerland.
   [Asrih, Mohamed; Papageorgiou, Irene; Montessuit, Christophe] Univ Geneva, Sch Med, Fdn Med Res, CH-1211 Geneva 4, Switzerland.
C3 University of Geneva; University of Geneva
RP Montessuit, C (corresponding author), Univ Geneva, Sch Med, Fdn Med Res, 64 Ave Roseraie, CH-1211 Geneva 4, Switzerland.
EM christophe.montessuit@unige.ch
RI Montessuit, Christophe/B-5650-2011
OI Montessuit, Christophe/0000-0002-2580-7711
FU Swiss National Science Foundation [310000-122001]; Fondation Centre de
   Recherche Medicale Carlos et Elsie de Reuter [472]; Fondation Novartis
   pour la Recherche Biomedicale [10B32]; SwissLife-Jubilaumsstiftung
FX This work was supported by grants from the Swiss National Science
   Foundation (no. 310000-122001), the Fondation Centre de Recherche
   Medicale Carlos et Elsie de Reuter (no. 472), the Fondation Novartis
   pour la Recherche Biomedicale (no. 10B32), and the
   SwissLife-Jubilaumsstiftung. We also wish to express gratitude to Prof.
   Francois Mach for additional financial support.
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NR 54
TC 11
Z9 11
U1 0
U2 11
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 0022-2828
EI 1095-8584
J9 J MOL CELL CARDIOL
JI J. Mol. Cell. Cardiol.
PD MAR
PY 2013
VL 56
BP 106
EP 115
DI 10.1016/j.yjmcc.2012.12.015
PG 10
WC Cardiac & Cardiovascular Systems; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Cell Biology
GA 090YS
UT WOS:000315016500013
PM 23277190
DA 2025-06-11
ER

PT J
AU Kawamoto, R
   Tabara, Y
   Kohara, K
   Miki, T
   Ohtsuka, N
   Kusunoki, T
   Takayama, S
   Abe, M
AF Kawamoto, Ryuichi
   Tabara, Yasuharu
   Kohara, Katsuhiko
   Miki, Tetsuro
   Ohtsuka, Nobuyuki
   Kusunoki, Tomo
   Takayama, Shouzo
   Abe, Masanori
TI Serum Gamma-Glutamyl Transferase within Its Normal Concentration Range
   Is Related to the Presence of Impaired Fasting Glucose and Diabetes
   among Japanese Community-Dwelling Persons
SO ENDOCRINE RESEARCH
LA English
DT Article
DE Gamma-glutamyl transferase; Impaired fasting glucose; Diabetes; Risk
   factor; Insulin resistance
ID C-REACTIVE PROTEIN; MIDDLE-AGED MEN; METABOLIC SYNDROME; OXIDATIVE
   STRESS; INSULIN-RESISTANCE; CARDIOVASCULAR-DISEASE; ADIPOSE-TISSUE;
   KOREAN ADULTS; DESIR COHORT; FATTY LIVER
AB Introduction. Serum gamma-glutamyl transferase (GGT) activity changes in response to oxidative stress. Little data are available on the association between serum GGT and the prevalence of impaired fasting glucose (IFG) and diabetes among Japanese community-dwelling persons. Methods. We recruited 871 men, aged 61 +/- 14 (range, 20-89) years, and 1,139 women, aged 63 +/- 12 (range, 21-88) years during their annual health examination from a single community. We performed a cross-sectional study to examine whether serum GGT was associated with IFG and diabetes. Results and conclusions. The levels of most confounding characteristics varied with increasing GGT activity. The prevalence of IFG and diabetes was significantly and linearly associated with increasing quartiles of serum GGT. After adjustment for sex, age, smoking status, drinking status, low-density lipoprotein cholesterol, uric acid, estimated glomerular filtration rate, and alanine aminotransferase, the odds ratio (OR) [95% confidence interval (CI)] for IFG compared with the participants with lowest quartile of serum GGT was 1.91 (1.31-2.78) for second quartiles, 2.41 (1.63-3.57) for third quartiles, and 3.24 (2.03-5.17) for highest quartiles. The multivariate-adjusted OR (95% CI) for diabetes was 1.91 (1.18-3.09) for second quartiles, 2.15 (1.30-3.54) for third quartiles, and 3.79 (2.11-6.82) for highest quartiles. Furthermore, the multivariate-adjusted ORs for IFG were also associated with increasing levels of serum GGT within subgroups of age, body mass index, drinking status, serum high-molecular-weight adiponectin levels, insulin resistance, and the presence of antihypertensive/antilipidemic medication. These results suggested that higher serum GGT within normal concentration range was significantly associated with IFG and diabetes in the general population.
C1 [Kawamoto, Ryuichi; Kusunoki, Tomo; Takayama, Shouzo; Abe, Masanori] Ehime Univ, Grad Sch Med, Dept Community Med, Seiyo, Ehime 7971212, Japan.
   [Kawamoto, Ryuichi; Ohtsuka, Nobuyuki; Kusunoki, Tomo] Seiyo Municipal Nomura Hosp, Dept Internal Med, Seiyo, Japan.
   [Tabara, Yasuharu; Kohara, Katsuhiko; Miki, Tetsuro] Ehime Univ, Grad Sch Med, Dept Geriatr Med, Seiyo, Ehime 7971212, Japan.
RP Kawamoto, R (corresponding author), Ehime Univ, Grad Sch Med, Dept Community Med, 9-53 Nomura,Nomura Cho, Seiyo, Ehime 7971212, Japan.
EM rykawamo@yahoo.co.jp
FU Foundation for Development of Community, Japan; Grants-in-Aid for
   Scientific Research [22659143, 23390188] Funding Source: KAKEN
FX This work was supported in part by a grant-in-aid from the Foundation
   for Development of Community, Japan (2009).
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NR 37
TC 10
Z9 13
U1 0
U2 5
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 0743-5800
J9 ENDOCR RES
JI Endocr. Res.
PY 2011
VL 36
IS 2
BP 64
EP 73
DI 10.3109/07435800.2010.534756
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 758KK
UT WOS:000290163400003
PM 21539445
DA 2025-06-11
ER

PT J
AU Zhao, H
   Zhai, BW
   Zhang, MY
   Huang, H
   Zhu, HL
   Yang, H
   Ni, HY
   Fu, YJ
AF Zhao, Heng
   Zhai, Bo-Wen
   Zhang, Mao -Yu
   Huang, Han
   Zhu, Han -Lin
   Yang, Han
   Ni, Hai-Yan
   Fu, Yu-Jie
TI Phlorizin from Lithocarpus litseifolius [Hance] Chun ameliorates
   FFA-induced insulin resistance by regulating AMPK/PI3K/AKT signaling
   pathway
SO PHYTOMEDICINE
LA English
DT Article
DE Phlorizin Insulin resistance; PI3K/AKT; AMPK; HepG2 cells
ID HEPG2 CELLS; GLUCOSE; FLAVONOIDS; METABOLISM; PALMITATE; JNK
AB Background: Insulin resistance (IR) is the central pathophysiological feature in the pathogenesis of metabolic syndrome, obesity, type 2 diabetes mellitus (T2DM), hypertension, and dyslipidemia. As the main active ingredient in Lithocarpus litseifolius [Hance] Chun, previous studies have shown that phlorizin (PHZ) can reduce insulin resistance in the liver. However, the effect of phlorizin on attenuating hepatic insulin resistance has not been fully investigated, and whether this effect is related to AMPK remains unclear. Purpose: The present study aimed to further investigate the effect of phlorizin on attenuating insulin resistance and the potential action mechanism. Methods: Free fatty acids (FFA) were used to induce insulin resistance in HepG2 cells. The effects of phlorizin and FFA on cell viability were detected by MTT analysis. Glucose consumption, glycogen synthesis, intracellular malondialdehyde (MDA), superoxide dismutase (SOD), total cholesterol (TC), and triglyceride (TG) contents were quantified after phlorizin treatment. Glucose uptake and reactive oxygen species (ROS) levels in HepG2 cells were assayed by flow cytometry. Potential targets and signaling pathways for attenuating insulin resistance by phlorizin were predicted by network pharmacological analysis. Moreover, the expression levels of proteins related to the AMPK/PI3K/AKT signaling pathway were detected by western blot. Results: Insulin resistance was successfully induced in HepG2 cells by co-treatment of 1 mM sodium oleate (OA) and 0.5 mM sodium palmitate (PA) for 24 h. Treatment with phlorizin promoted glucose consumption, glucose uptake, and glycogen synthesis and inhibited gluconeogenesis in IR-HepG2 cells. In addition, phlorizin inhibited oxidative stress and lipid accumulation in IR-HepG2 cells. Network pharmacological analysis showed that AKT1 was the active target of phlorizin, and the PI3K/AKT signaling pathway may be the potential action mechanism of phlorizin. Furthermore, western blot results showed that phlorizin ameliorated FFA-induced insulin resistance by activating the AMPK/PI3K/AKT signaling pathway. Conclusion: Phlorizin inhibited oxidative stress and lipid accumulation in IR-HepG2 cells and ameliorated hepatic insulin resistance by activating the AMPK/PI3K/AKT signaling pathway. Our study proved that phlorizin played
C1 [Zhao, Heng; Zhai, Bo-Wen; Zhang, Mao -Yu; Huang, Han; Zhu, Han -Lin; Yang, Han; Ni, Hai-Yan] Northeast Forestry Univ, Minist Educ, Key Lab Forest Plant Ecol, Harbin 150040, Peoples R China.
   [Zhao, Heng; Zhai, Bo-Wen; Zhang, Mao -Yu; Huang, Han; Zhu, Han -Lin; Yang, Han; Ni, Hai-Yan] Northeast Forestry Univ, Engn Res Ctr Forest Biopreparat, Minist Educ, Harbin 150040, Peoples R China.
   [Zhao, Heng; Zhai, Bo-Wen; Zhang, Mao -Yu; Huang, Han; Zhu, Han -Lin; Yang, Han; Ni, Hai-Yan; Fu, Yu-Jie] Northeast Forestry Univ, Coll Chem Chem Engn & Resource Utilizat, Harbin 150040, Peoples R China.
   [Fu, Yu-Jie] Beijing Forestry Univ, Coll Forestry, Beijing 100083, Peoples R China.
C3 Ministry of Education - China; Northeast Forestry University - China;
   Ministry of Education - China; Northeast Forestry University - China;
   Northeast Forestry University - China; Beijing Forestry University
RP Fu, YJ (corresponding author), Beijing Forestry Univ, Coll Forestry, Beijing 100083, Peoples R China.
EM yujie_fu@163.com
OI Zhai, Bowen/0000-0002-4343-4779
FU The 111 Center [B20088]; National XA Science and Technology Innovation
   Project [2022XACX1100]; Fundamental Research Funds for the Central
   Universities [2572020DR07]
FX The authors gratefully acknowledge the financial support by The 111
   Center (B20088) , the National XA Science and Technology Innovation
   Project (2022XACX1100) , Fundamental Research Funds for the Central
   Universities (2572020DR07).
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NR 30
TC 11
Z9 11
U1 27
U2 68
PU ELSEVIER GMBH
PI MUNICH
PA HACKERBRUCKE 6, 80335 MUNICH, GERMANY
SN 0944-7113
EI 1618-095X
J9 PHYTOMEDICINE
JI Phytomedicine
PD JUL 25
PY 2024
VL 130
AR 155743
DI 10.1016/j.phymed.2024.155743
EA JUN 2024
PG 11
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA UQ8C6
UT WOS:001249605300001
PM 38824822
DA 2025-06-11
ER

PT J
AU Sudy, AR
   Ella, K
   Bódizs, R
   Káldi, K
AF Sudy, Agnes Reka
   Ella, Krisztina
   Bodizs, Robert
   Kaldi, Krisztina
TI Association of Social Jetlag With Sleep Quality and Autonomic Cardiac
   Control During Sleep in Young Healthy Men
SO FRONTIERS IN NEUROSCIENCE
LA English
DT Article
DE autonomic nervous system; heart rate variability; sleep quality;
   circadian misalignment; social jetlag; cardiovascular risk factor
ID HEART-RATE-VARIABILITY; CIRCADIAN MISALIGNMENT; CARDIOVASCULAR-DISEASE;
   SHIFT WORK; METABOLIC SYNDROME; NERVOUS-SYSTEM; BLOOD-PRESSURE;
   RISK-FACTORS; STRESS; METAANALYSIS
AB Social jetlag (SJL), the difference in sleep timing between work and free days is a consequence of the discrepancy between the individual's circadian rhythm and the social clock. SJL is considered a chronic stress factor and has been linked to various health problems. In this field study, we examined for the first time the association between SJL and cardiac regulation during sleep. 33 healthy young men aged 20-26 years participated in the study. The median SJL was used as a cut-off value to assign the participants into two groups with either lower or higher SJL. As a marker of autonomic control we analyzed heart rate variability (HRV) and addressed intra-individual differences between workdays and free days. In subjects with higher SJL, pNN50, an indicator of vagal activity was lower in the first 3 h of sleep on workday as compared to free day (day x sleep block x group, p = 0.015), indicating a more adaptable regulation on free days, when subjects slept according to their own preference. However, in subjects with lower SJL, no HRV differences were found between the two nights. SJL showed correlation with the free day-workday differences of both pNN50 and another vagal index, RMSSD in the first 2 h of sleep (p = 0.023 and 0.047, respectively). In subjects with higher SJL, a different HF power on workdays and free days (p = 0.031) also indicated that a shift in sleep timing is accompanied by an altered parasympathetic activity in the first few hours of sleep. Furthermore, subjective sleep quality on workdays was negatively associated with SJL (p = 0.02), and subjects with higher SJL reported worse sleep quality on workday than on free day (p = 0.027). Taken together, our data call attention on the potential effect of SJL on sleep quality and vagal activity during sleep.
C1 [Sudy, Agnes Reka; Ella, Krisztina; Kaldi, Krisztina] Semmelweis Univ, Dept Physiol, Budapest, Hungary.
   [Bodizs, Robert] Semmelweis Univ, Inst Behav Sci, Budapest, Hungary.
   [Bodizs, Robert] Natl Inst Clin Neurosci, Budapest, Hungary.
   [Kaldi, Krisztina] Semmelweis Univ, Dept Lab Med, Budapest, Hungary.
C3 Semmelweis University; Semmelweis University; Semmelweis University
RP Káldi, K (corresponding author), Semmelweis Univ, Dept Physiol, Budapest, Hungary.; Káldi, K (corresponding author), Semmelweis Univ, Dept Lab Med, Budapest, Hungary.
EM kaldi.krisztina@med.semmelweis-univ.hu
RI Bódizs, Róbert/A-2651-2009; Ella, Krisztina/N-8552-2017
OI Bodizs, Robert/0000-0001-5341-060X; Ella, Krisztina/0000-0003-4961-5615
FU National Research, Development and Innovation Office - NKFIH [K115953];
   Higher Education Institutional Excellence Programme of the Ministry of
   Human Capacities in Hungary
FX This work was supported by the National Research, Development and
   Innovation Office - NKFIH (K115953) and the Higher Education
   Institutional Excellence Programme of the Ministry of Human Capacities
   in Hungary, within the framework of the FIKP programme of the Semmelweis
   University. KK, KE, and RB are Merit Scholars of the Semmelweis
   University.
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NR 63
TC 46
Z9 50
U1 5
U2 14
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1662-453X
J9 FRONT NEUROSCI-SWITZ
JI Front. Neurosci.
PD SEP 6
PY 2019
VL 13
AR 950
DI 10.3389/fnins.2019.00950
PG 10
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA IV8XO
UT WOS:000484548600001
PM 31555086
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Patel, R
   Varghese, JE
   Singh, RP
   Yadav, UCS
AF Patel, Rohit
   Varghese, Johnna E.
   Singh, Rana P.
   Yadav, Umesh C. S.
TI Induction of endothelial dysfunction by oxidized low-density
   lipoproteins via downregulation of Erk-5/Mef2c/KLF2 signaling:
   Amelioration by fisetin
SO BIOCHIMIE
LA English
DT Article
DE Atherosclerosis; Oxidized-LDL; Endothelial dysfunction; Erk-5 signaling;
   pHUVECs; Fisetin
ID METABOLIC SYNDROME; FACTOR-2 KLF2; PROTEIN; ERK5; ACTIVATION; CELLS;
   RISK; INFLAMMATION; EXPRESSION; BMK1/ERK5
AB Extra-cellular signal regulated kinase-5 (Erk-5), a transcriptional activator and regulator of endothelial cells (ECs) homeostasis, has been implicated in shear stress-induced endothelial dysfunction (ED), however its role in oxidized low-density lipoprotein (oxLDL)- induced ED during metabolic stress is not known. Herein, regulation and function of Erk-5 in oxLDL-induced EC death, inflammation and dysfunction has been investigated. Primary Human Umbilical Vein Endothelial Cells (pHUVECs) were stimulated with oxLDL. MTT and Trypan blue exclusion assays to assess cell viability, RT-qPCR and Western blotting assays to determine expression of endothelial and inflammatory markers and ED mediators at mRNA and protein levels, respectively were performed. Monocyte adhesion assay was performed to examine monocytes adherence to oxLDL-stimulated pHUVECs. The exposure of oxLDL induced a dose- and time-dependent decrease in pHUVECs viability, which concurred with decreased Erk-5 expression. Further, oxLDL (100 mu g/ml) decreased the expression of endothelial markers eNOS and vWF, and increased the expression of ICAM-1, at both mRNA and protein levels. SiRNA-mediated silencing of Erk-5 or its inhibition showed that changes in eNOS, vWF and ICAM-1 expression could be mediated through Erk-5. Furthermore, oxLDL decreased the levels of Erk-5's upstream regulator MEK5 and downstream regulators Mef2c and KLF2, which were similar to their expressions in Erk-5 silenced cells. Fisetin, a phytochemical and bioflavonoid, could reduce the effect of oxLDL in ECs by upregulating the expression of endothelial markers including Erk-5, and downregulating the expression of inflammation markers. These results suggest that Erk-5 could be a critical regulator of oxLDL-induced EC death, inflammation and dysfunction via downregulation of Erk-5/Mef2c-KLF2 signaling pathway, which can be ameliorated by a bioflavonoid, fisetin. (C) 2019 Elsevier B.V. and Societe Francaise de Biochimie et Biologie Moleculaire (SFBBM). All rights reserved.
C1 [Patel, Rohit; Varghese, Johnna E.; Yadav, Umesh C. S.] Cent Univ Gujarat, Sch Life Sci, Metab Disorders & Inflammatory Pathol Lab, Sect 30, Gandhinagar 382030, Gujarat, India.
   [Singh, Rana P.] Jawaharlal Nehru Univ, Sch Life Sci, New Delhi 110067, India.
C3 Central University of Gujarat; Jawaharlal Nehru University, New Delhi
RP Yadav, UCS (corresponding author), Cent Univ Gujarat, Sch Life Sci, Metab Disorders & Inflammatory Pathol Lab, Sect 30, Gandhinagar 382030, Gujarat, India.
EM umeshyadav@cug.ac.in
RI Patel, Rohit/HPO-4009-2023; Singh, Rana/JZT-2038-2024; Varghese,
   Johnna/HJY-2915-2023
OI Varghese, Johnna Francis/0000-0001-9152-2880; Patel,
   Rohit/0000-0001-8432-4616; Singh, Rana Pratap/0000-0003-4261-7044
FU Science and Engineering Research Board (SERB)/Department of Science and
   Technology (DST), Government of India (GOI) [ECR/2015/000266,
   SERB/F/5252/2016-17]; SERB, Govt. of India; GSBTM, Govt. of Gujarat
FX This work was funded by Early Career Award (ECR/2015/000266;
   SERB/F/5252/2016-17) to UCSY by Science and Engineering Research Board
   (SERB)/Department of Science and Technology (DST), Government of India
   (GOI). Junior Research Fellowships (JRF) to RP from SERB, Govt. of India
   and to JFV from GSBTM, Govt. of Gujarat, are thankfully acknowledged.
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NR 43
TC 24
Z9 27
U1 0
U2 9
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0300-9084
EI 1638-6183
J9 BIOCHIMIE
JI Biochimie
PD AUG
PY 2019
VL 163
BP 152
EP 162
DI 10.1016/j.biochi.2019.06.007
PG 11
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA IH2YO
UT WOS:000474360700016
PM 31199942
DA 2025-06-11
ER

PT J
AU Schiappacassa, A
   Maranhao, PA
   de Souza, MDC
   Panazzolo, DG
   Neto, JFN
   Bouskela, E
   Kraemer-Aguiar, LG
AF Schiappacassa, Alessandra
   Maranhao, Priscila A.
   Coelho de Souza, Maria das Gracas
   Panazzolo, Diogo G.
   Nogueira Neto, Jose Firmino
   Bouskela, Eliete
   Kraemer-Aguiar, Luiz Guilherme
TI Acute Effects of Metformin and Vildagliptin after a Lipid-Rich Meal on
   Postprandial Microvascular Reactivity in Patients with Type 2 Diabetes
   and Obesity: A Randomized Trial
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Article
DE diabetes; microcirculation; metformin; vildagliptin; postprandial
ID CARDIOVASCULAR-DISEASE; ENDOTHELIAL FUNCTION; METABOLIC SYNDROME;
   GLUCOSE; CHOLESTEROL; INSULIN; ASSOCIATION; DYSFUNCTION; PLASMA; GLP-1
AB Background: Type 2 diabetes mellitus and obesity are both related to endothelial dysfunction. Postprandial lipemia is a cardiovascular risk. Notably, it is known that a high-fat diet may elicit microvascular dysfunction, even in healthy subjects. Since anti-diabetic drugs have different mechanisms of action and also distinct vascular benefits, we aimed to compare the results of two anti-diabetic drugs after the intake of a lipid-rich meal on microcirculation in patients with type 2 diabetes and obesity. In parallel, we also investigated the metabolic profile, oxidative stress, inflammation, plasma viscosity, and some gastrointestinal peptides. Subjects/Methods: We included 38 drug-naive patients, all women aged between 19 and 50 years, with BMI >= 30 kg/m(2). We performed endothelial measurements and collected samples before (fasting) and after the intake of a lipid-rich meal at 30, 60, 120, and 180 min. Patients were randomized to metformin or vildagliptin, given orally just before the meal. Endothelial function was assessed by videocapillaroscopy and laser-Doppler flowmetry to investigate microvascular reactivity. Besides, we also investigated plasma viscosity, inflammatory and oxidative stress biomarkers, gastrointestinal peptides, and metabolic profile in all time points. Results: No differences at baseline were noted between groups. Vildagliptin increased glucagon-like peptide-1 compared to metformin. Paired comparisons showed that, during the postprandial period, vildagliptin significantly changed levels of insulin and glucagon-like peptide-1, and also the dipeptidyl peptidase-4 activity, while metformin had effects on plasma glucose solely. Metformin use during the test meal promoted an increase in functional capillary density, while vildagliptin kept non-nutritive microvascular blood flow and vasomotion unchanged. Conclusions: After the intake of a lipid-rich meal, the use of vildagliptin preserved postprandial non-nutritive microflow and vasomotion, while metformin increased capillary recruitment, suggesting protective and different mechanisms of action on microcirculation.
C1 [Schiappacassa, Alessandra; Maranhao, Priscila A.; Coelho de Souza, Maria das Gracas; Panazzolo, Diogo G.] Univ Estado Rio De Janeiro, Fac Med Sci, Postgrad Program Clin & Expt Physiopathol FISCLIN, BR-20550013 Rio De Janeiro, RJ, Brazil.
   [Coelho de Souza, Maria das Gracas; Bouskela, Eliete; Kraemer-Aguiar, Luiz Guilherme] Univ Estado Rio De Janeiro, Biomed Ctr, Lab Clin & Expt Res Vasc Biol BioVasc, BR-20550013 Rio De Janeiro, RJ, Brazil.
   [Nogueira Neto, Jose Firmino] Univ Estado Rio De Janeiro, Policlin Piquet Carneiro, Lipids Lab Lablip, BR-20550003 Rio De Janeiro, RJ, Brazil.
   [Kraemer-Aguiar, Luiz Guilherme] Univ Estado Rio De Janeiro, Fac Med Sci, Dept Internal Med, Obes Unit,Policlin Piquet Carneiro, BR-20550030 Rio De Janeiro, RJ, Brazil.
C3 Universidade do Estado do Rio de Janeiro; Universidade do Estado do Rio
   de Janeiro; Universidade do Estado do Rio de Janeiro; Universidade do
   Estado do Rio de Janeiro
RP Kraemer-Aguiar, LG (corresponding author), Univ Estado Rio De Janeiro, Biomed Ctr, Lab Clin & Expt Res Vasc Biol BioVasc, BR-20550013 Rio De Janeiro, RJ, Brazil.; Kraemer-Aguiar, LG (corresponding author), Univ Estado Rio De Janeiro, Fac Med Sci, Dept Internal Med, Obes Unit,Policlin Piquet Carneiro, BR-20550030 Rio De Janeiro, RJ, Brazil.
EM a_schiappacassa@hotmail.com; priscilamaranhao@gmail.com;
   mgcsouza@gmail.com; drdiogopanazzolo@gmail.com; firminouerj@gmail.com;
   eliete.bouskela@gmail.com; lgkraemeraguiar@gmail.com
RI Kraemer-Aguiar, Luiz Guilherme/ABG-2833-2022; Maranhão,
   Priscila/F-2624-2013
OI Maranhao, Priscila/0000-0002-4804-4999; Kraemer-Aguiar, Luiz
   Guilherme/0000-0002-3528-5881; Souza, Maria das
   Gracas/0000-0001-5512-2871; PANAZZOLO, DIOGO/0000-0002-9066-0728
FU Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq,
   Brazil); Fundacao Carlos Chagas Filho de Amparo a Pesquisa do Estado do
   Rio de Janeiro (FAPERJ, Brazil); Novartis S.A (Switzerland)
FX EB and LGK-A received supports for research from Conselho Nacional de
   Desenvolvimento Cientifico e Tecnologico (CNPq, Brazil) and Fundacao
   Carlos Chagas Filho de Amparo a Pesquisa do Estado do Rio de Janeiro
   (FAPERJ, Brazil). This work was partially supported by Novartis S.A
   (Switzerland) as a study by an initiative of the guarantor of this
   research (LGK-A).
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NR 34
TC 5
Z9 5
U1 0
U2 3
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD OCT
PY 2020
VL 9
IS 10
AR 3228
DI 10.3390/jcm9103228
PG 11
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA OL7PB
UT WOS:000585525800001
PM 33050169
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Zhang, PG
   Jiang, GY
   Wang, YB
   Yan, EF
   He, LJ
   Guo, JX
   Yin, JD
   Zhang, X
AF Zhang, Pengguang
   Jiang, Guoyuan
   Wang, Yubo
   Yan, Enfa
   He, Linjuan
   Guo, Jianxin
   Yin, Jingdong
   Zhang, Xin
TI Maternal consumption of L-malic acid enriched diets improves antioxidant
   capacity and glucose metabolism in offspring by regulating the gut
   microbiota
SO REDOX BIOLOGY
LA English
DT Article
DE Maternal L -malic acid consumption; Sows and piglets; Inflammatory
   response; Antioxidant capacity; Glucose metabolism; Gut microbiota
ID OXIDATIVE STRESS; SKELETAL-MUSCLE; BIOSYNTHESIS; INFLAMMATION; OBESITY;
   NRF2; CLINOPTILOLITE; ENZYME; MODEL
AB Maternal diets during pregnancy and lactation are key determinants that regulate the development of metabolic syndrome (MetS) in offspring. L-malic acid (MA) was previously reported to improve antioxidant capacity and aerobic metabolism. However, the effects of maternal MA consumption on the metabolic features of offspring remain largely unexplored. Herein, through pig models consuming MA-enriched diets during late pregnancy and lactation, we found that maternal MA consumption potentiated the anti-inflammatory and antioxidant capacity of sows, thereby improving their reproductive performance and the growth performance of piglets. Maternal MA consumption also induced a transition of slow-twitch to fast-twitch fibers in the early life of offspring. Along with muscle growth and fiber-type transition, insulin sensitivity and glucose metabolism, including aerobic metabolism and glycolysis, were improved in the skeletal muscle of offspring. An untargeted metabolomic analysis further revealed the contribution of modified amino acid metabolism to the improved aerobic metabolism. Mechanistically, maternal MA consumption remodeled colonic microbiota of their offspring. Briefly, the abundance of Colidextribacter, Romboutsia, and Family_XIII_AD3011_group increased, which were positively associated with the antioxidant capacity and glucose metabolism of skeletal muscles. A decreased abundance of Prevotella, Blautia, Prevotellaceae_NK3B31_group, and Collinsella was also detected, which were involved in less insulin sensitivity. Notably, milk metabolites, such as ascorbic acid (AA) and granisetron (GS), were found as key effectors regulating the gut microbiota composition of piglets. The properties of AA and GS in alleviating insulin resistance, inflammation, and oxidative stress were further verified through mice treated with high-fat diets. Overall, this study revealed that maternal MA consumption could modulate the inflammatory response, antioxidant capacity, and glucose metabolism by regulating the gut microbiota of offspring through the vertical transmission of milk metabolites. These findings suggest the potential of MA in the prevention and treatment of MetS in early life.
C1 [Zhang, Pengguang; Jiang, Guoyuan; Wang, Yubo; Yan, Enfa; He, Linjuan; Guo, Jianxin; Yin, Jingdong; Zhang, Xin] China Agr Univ, Coll Anim Sci & Technol, State Key Lab Anim Nutr & Feeding, Beijing 100193, Peoples R China.
C3 China Agricultural University
RP Yin, JD; Zhang, X (corresponding author), China Agr Univ, Coll Anim Sci & Technol, State Key Lab Anim Nutr & Feeding, Beijing 100193, Peoples R China.
EM yinjd@cau.edu.cn; zhangx0904@cau.edu.cn
RI Guo, jianxin/LFR-9902-2024
OI He, Linjuan/0000-0002-0473-0065; Zhang, Xin/0000-0003-2632-4567
FU National Key Research and Development Program of China [2021YFF1000603,
   2021YFD1300403]; National Natural Science Foundation of China
   [32102555]; Young Elite Scientists Sponsorship Program by CAST
   [2022QNRC001]
FX This work was supported by the National Key Research and Development
   Program of China (grant numbers 2021YFF1000603 and 2021YFD1300403), the
   National Natural Science Foundation of China (grant number 32102555),
   and Young Elite Scientists Sponsorship Program by CAST (grant number
   2022QNRC001).
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NR 74
TC 25
Z9 26
U1 12
U2 47
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2213-2317
J9 REDOX BIOL
JI Redox Biol.
PD NOV
PY 2023
VL 67
AR 102889
DI 10.1016/j.redox.2023.102889
EA SEP 2023
PG 18
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA EH1I4
UT WOS:001137935300001
PM 37741046
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Baboota, RK
   Spinelli, R
   Erlandsson, MC
   Brandao, BB
   Lino, M
   Yang, H
   Mardinoglu, A
   Bokarewa, MI
   Boucher, J
   Kahn, CR
   Smith, U
AF Baboota, Ritesh K.
   Spinelli, Rosa
   Erlandsson, Malin C.
   Brandao, Bruna B.
   Lino, Marsel
   Yang, Hong
   Mardinoglu, Adil
   Bokarewa, Maria I.
   Boucher, Jeremie
   Kahn, C. Ronald
   Smith, Ulf
TI Chronic hyperinsulinemia promotes human hepatocyte senescence
SO MOLECULAR METABOLISM
LA English
DT Article
DE Keywords Hyperinsulinemia; Senescence; Hepatocytes; NAFLD; Dasatinib;
   Quercetin
ID SELECTIVE INSULIN-RESISTANCE; CELLULAR SENESCENCE; HUMAN-CELLS;
   MECHANISMS; DISEASE; LEADS
AB Objective: Cellular senescence, an irreversible proliferative cell arrest, is caused by excessive intracellular or extracellular stress/damage. Increased senescent cells have been identified in multiple tissues in different metabolic and other aging-related diseases. Recently, several human and mouse studies emphasized the involvement of senescence in development and progression of NAFLD. Hyperinsulinemia, seen in obesity, metabolic syndrome, and other conditions of insulin resistance, has been linked to senescence in adipocytes and neurons. Here, we investigate the possible direct role of chronic hyperinsulinemia in the development of senescence in human hepatocytes.Methods: Using fluorescence microscopy, immunoblotting, and gene expression, we tested senescence markers in human hepatocytes subjected to chronic hyperinsulinemia in vitro and validated the data in vivo by using liver-specific insulin receptor knockout (LIRKO) mice. The consequences of hyperinsulinemia were also studied in senescent hepatocytes following doxorubicin as a model of stress-induced senescence. Furthermore, the effects of senolytic agents in insulin- and doxorubicin-treated cells were analyzed.Results: Results showed that exposing the hepatocytes to prolonged hyperinsulinemia promotes the onset of senescence by increasing the expression of p53 and p21. It also further enhanced the senescent phenotype in already senescent hepatocytes. Addition of insulin signaling pathway inhibitors prevented the increase in cell senescence, supporting the direct contribution of insulin. Furthermore, LIRKO mice, in which insulin signaling in the liver is abolished due to deletion of the insulin receptor gene, showed no differences in senescence compared to their wildtype counterparts despite having marked hyperinsulinemia indicating these are receptor-mediated effects. In contrast, the persistent hyperinsulinemia in LIRKO mice enhanced senescence in white adipose tissue. In vitro, senolytic agents dasatinib and quercetin reduced the prosenescent effects of hyperinsulinemia in hepatocytes.Conclusion: Our findings demonstrate a direct link between chronic hyperinsulinemia and hepatocyte senescence. This effect can be blocked by reducing the levels of insulin receptors or administration of senolytic drugs, such as dasatinib and quercetin.(c) 2022 The Author(s). Published by Elsevier GmbH. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
C1 [Baboota, Ritesh K.; Spinelli, Rosa; Boucher, Jeremie; Smith, Ulf] Univ Gothenburg, Sahlgrenska Acad, Dept Mol & Clin Med, Lundberg Lab Diabet Res, Gothenburg, Sweden.
   [Spinelli, Rosa] Federico II Univ Naples, Dept Translat Med Sci, Naples, Italy.
   [Spinelli, Rosa] CNR, Inst Expt Endocrinol & Oncol, URT Genom Diabet, Naples, Italy.
   [Erlandsson, Malin C.; Bokarewa, Maria I.] Univ Gothenburg, Inst Med, Dept Rheumatol & flammat Res, Gothenburg, Sweden.
   [Erlandsson, Malin C.; Bokarewa, Maria I.] Sahlgrens Univ Hosp, Rheumatol Clin, Gothenburg, Sweden.
   [Brandao, Bruna B.; Kahn, C. Ronald] Joslin Diabet Ctr, One Joslin Pl, Boston, MA USA.
   [Brandao, Bruna B.; Kahn, C. Ronald] Harvard Med Sch, One Joslin Pl, Boston, MA USA.
   [Yang, Hong; Mardinoglu, Adil] KTH Royal Inst Technol, Sci Life Lab, Stockholm, Sweden.
   [Boucher, Jeremie] Evotec Int GmbH, Metab Dis, Gottingen, Germany.
   [Smith, Ulf] Sahlgrens Univ Hosp, Dept Mol & Clin Med, Lundberg Lab Diabet Res, Bla Straket 5, SE-41345 Gothenburg, Sweden.
C3 University of Gothenburg; University of Naples Federico II; Consiglio
   Nazionale delle Ricerche (CNR); University of Gothenburg; Sahlgrenska
   University Hospital; Harvard University; Harvard University Medical
   Affiliates; Joslin Diabetes Center, Inc.; Harvard University; Harvard
   Medical School; Royal Institute of Technology; Evotec; Sahlgrenska
   University Hospital
RP Smith, U (corresponding author), Sahlgrens Univ Hosp, Dept Mol & Clin Med, Lundberg Lab Diabet Res, Bla Straket 5, SE-41345 Gothenburg, Sweden.
EM ulf.smith@medic.gu.se
RI SPINELLI, ROSA/KWT-6848-2024; Brandao, Bruna/AAY-3939-2021; Baboota,
   Ritesh/AAQ-2606-2020; Kahn, Ronald/AAY-2435-2021; Bokarewa,
   Maria/A-8114-2019; Lino, Marsel/HHN-1235-2022; Mardinoglu,
   Adil/AAS-6360-2021
OI Smith, Ulf/0000-0002-1439-4608; Lino, Marsel/0000-0001-9662-6339
FU Knut and Alice Wallenberg Foundation; Swedish Research Council; Novo
   Nordisk Foundation; Heart and Lung Foundation; Swedish Diabetes Research
   Foundation; National Institutes of Health [R01DK031036]
FX We acknowledge financial support from the Knut and Alice Wallenberg
   Foundation, the Swedish Research Council, the Novo Nordisk Foundation,
   the Heart and Lung Foundation, and the Swedish Diabetes Research
   Foundation. C.R.K. was supported by a grant from the National Institutes
   of Health (R01DK031036)
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NR 33
TC 25
Z9 27
U1 2
U2 11
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2212-8778
J9 MOL METAB
JI Mol. Metab.
PD OCT
PY 2022
VL 64
AR 101558
DI 10.1016/j.molmet.2022.101558
EA AUG 2022
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 3Z0DV
UT WOS:000844092400003
PM 35872305
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Hu, MM
   Chen, JH
   Zhang, QQ
   Song, ZY
   Shaukat, H
   Qin, H
AF Hu, Min-Min
   Chen, Ji-Hua
   Zhang, Quan-Quan
   Song, Zi-Yu
   Shaukat, Horia
   Qin, Hong
TI Sesamol counteracts on metabolic disorders of middle-aged alimentary
   obese mice through regulating skeletal muscle glucose and lipid
   metabolism
SO FOOD & NUTRITION RESEARCH
LA English
DT Article
DE sesamol; obesity; aging; skeletal muscle; glucose metabolism; lipid
   metabolism
ID FATTY LIVER-DISEASE; INSULIN-RESISTANCE; ACCUMULATION; EXPRESSION;
   KINASE; PHYTOCHEMICALS; INFLAMMATION; HOMEOSTASIS; INHIBITION; CELLS
AB Background: Globally, obesity is a significant public problem, especially when aging. Sesamol, a phenolic lignan present in sesame seeds, might have a positive effect on high-fat diet (HFD)-induced obesity associated with aging.
   Objective: The purpose of current research study was to explore salutary effects and mechanisms of sesamol in treating alimentary obesity and associated metabolic syndrome in middle-aged mice.
   Methods: C57BL/6J mice aged 4-6 weeks and 6-8 months were assigned to the young normal diet group, middle-aged normal diet group, middle-aged IIFD group, and middle-aged IIFD + sesamol group. At the end of experiment, glucose tolerance test and insulin tolerance test were performed; the levels of lipids and oxidative stress-related factors in the serum and skeletal muscle were detected using chemistry reagent kits; lipid accumulation in skeletal muscle was observed by oil red O staining; the expressions of muscular glucose and lipid metabolism associated proteins were measured by Western blotting.
   Results: Sesamol decreased the body weight and alleviated obesity-associated metabolism syndrome in middle-aged mice, such as glucose intolerance, insulin resistance, dyslipidemia, and oxidative stress. Moreover, muscular metabolic disorders were attenuated after treatment with sesamol. It increased the expression of glucose transporter type-4 and down-regulated the protein levels of pyruvate dehydrogenase kinase isozyme 4, implying the increase of glucose uptake and oxidation. Meanwhile, sesamol decreased the expression of sterol regulatory element binding protein lc and up-regulated the phosphorylation of hormone-sensitive lipase and the level of carnitine palmityl transferase l alpha, which led to the declined lipogenesis and the increased lipolysis and lipid oxidation. In addition, the SIRT1/AMPK signaling pathway was triggered by sesamol, from which it is understood how sesamol enhances glucose and lipid metabolism.
   Conclusions: Sesamol counteracts on metabolic disorders of middle-aged alimentary obese mice through regulating skeletal muscle glucose and lipid metabolism, which might be associated with the stimulation of the SIRT1/AMPK pathway.
C1 [Hu, Min-Min; Chen, Ji-Hua; Zhang, Quan-Quan; Song, Zi-Yu; Shaukat, Horia; Qin, Hong] Cent South Univ, Xiangya Sch Publ Hlth, Dept Nutr Sci & Food Hyg, Changsha, Peoples R China.
C3 Central South University
RP Qin, H (corresponding author), 110 Xiangya Rd, Changsha 410078, Hunan, Peoples R China.
EM qinhong@csu.edu.cn
RI Qin, Hong/HLX-4770-2023
OI Qin, Hong/0000-0002-4578-5118
FU National Natu-ral Science Foundation of China [82073556]; Natural
   Science Foundation of Hunan Province [2021JJ30906]; Changsha Municipal
   Natural Sci-ence Foundation [kq2007074]
FX This research study was funded by the National Natu-ral Science
   Foundation of China (No. 82073556) , the Natural Science Foundation of
   Hunan Province (No.2021JJ30906) , and the Changsha Municipal Natural
   Sci-ence Foundation (No. kq2007074) .
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NR 54
TC 7
Z9 8
U1 5
U2 23
PU SWEDISH NUTRITION FOUNDATION-SNF
PI LUND
PA IDEON SCIENCE PARK, BESOK SCHEELEV 17 BETA 5, 3V, LUND, 223 70, SWEDEN
SN 1654-6628
EI 1654-661X
J9 FOOD NUTR RES
JI Food Nutr. Res.
PD MAR 17
PY 2022
VL 66
AR 8231
DI 10.29219/fnr.v66.8231
PG 13
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA ZZ5HT
UT WOS:000773300400001
PM 35382382
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Kramer, B
   França, LM
   Zhang, YH
   Paes, AMD
   Gerdes, AM
   Carrillo-Sepulveda, MA
AF Kramer, Benjamin
   Franca, Lucas Martins
   Zhang, Youhua
   de Andrade Paes, Antonio Marcus
   Gerdes, A. Martin
   Carrillo-Sepulveda, Maria Alicia
TI Western diet triggers Toll-like receptor 4 signaling-induced endothelial
   dysfunction in female Wistar rats
SO AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
LA English
DT Article
DE endothelial dysfunction; female rat; Toll-like receptor 4 signaling;
   Western diet
ID HIGH-FAT DIET; ENDOPLASMIC-RETICULUM STRESS; INSULIN-RESISTANCE;
   METABOLIC SYNDROME; NITRIC-OXIDE; VASCULAR DYSFUNCTION;
   DIABETES-MELLITUS; OXIDATIVE STRESS; CELL; INHIBITION
AB Overconsumption of a diet rich in fat and carbohydrates, called the Western diet, is a major contributor to the global epidemic of cardiovascular disease. Despite previously documented cardiovascular protection exhibited in female rats, this safeguard may be lost under certain metabolic stressors. We hypothesized that female Wistar rats challenged by a Western diet composed of 21% fat and 50% carbohydrate (34.1% sucrose) for 17 wk would develop endothelial dysfunction via endothelial Toll-like receptor 4 (TLR4) signaling. Western diet-fed female rats exhibited dysregulation of metabolism, revealing increased body weight and abdominal fat, decreased expression of adiponectin in white adipose tissue, glucose intolerance, and impaired insulin sensitivity. Western diet exposure increased hepatic triglycerides and cholesterol alongside hepatic steatosis, categorizing nonalcoholic fatty liver disease. Moreover, a Western diet negatively affected vascular function, revealing hypertension, impaired endothelium-dependent vasorelaxation, aortic remodeling, and increased reactive oxygen species (ROS) production. Aortic protein expression of TLR4 and its downstream proteins were markedly increased in the Western diet-fed group in association with elevated serum levels of free fatty acids. In vitro experiments were conducted to test whether free fatty acids contribute to vascular ROS overproduction via the TLR4 signaling pathway. Cultured endothelial cells were stimulated with palmitate in the presence of TAK-242, a TLR4 signaling inhibitor. Palmitate-induced overgeneration of ROS in endothelial cells was abolished in the presence of TAK-242. Our data show that a Western diet induced endothelial dysfunction in female rats and suggest that endothelial TLR4 signaling may play a key role in abolishing female cardiovascular protection.
   NEW & NOTEWORTHY A Western diet induced elevated levels of free fatty acids, produced nonalcoholic fatty liver disease, and provoked endothelial dysfunction in female rats in association with Toll-like receptor 4 signaling-mediated vascular reactive oxygen species production. Limited consumption of a Western diet in premenopausal women may decrease their risk of cardiovascular complications.
C1 [Kramer, Benjamin; Zhang, Youhua; Gerdes, A. Martin; Carrillo-Sepulveda, Maria Alicia] New York Inst Technol, Dept Biomed Sci, Old Westbury, NY 11568 USA.
   [Franca, Lucas Martins; de Andrade Paes, Antonio Marcus] Univ Fed Maranhao, Lab Expt Physiol, Dept Physiol Sci, Sao Luis, Brazil.
C3 New York Institute Technology; Universidade Federal do Maranhao
RP Carrillo-Sepulveda, MA (corresponding author), New York Inst Technol, Dept Biomed Sci, Northern Blvd, Old Westbury, NY 11568 USA.
EM mcarrill@nyit.edu
RI França, Lucas/IAM-5986-2023; Paes, Antonio/C-7174-2013
OI Martins Franca, Lucas/0000-0002-4412-1539
FU Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior of Brazil
   [PSDE-88881.133054/2016-01]; Faculty Development Grant from NYITCOM;
   American Heart Association
FX L. M. Franca was supported by a doctoral scholarship from Coordenacao de
   Aperfeicoamento de Pessoal de Nivel Superior of Brazil
   (PSDE-88881.133054/2016-01). This work was supported by a Faculty
   Development Grant from NYITCOM (to M. A. Carrillo-Sepulveda). B. Kramer
   holds a scholarship from the American Heart Association.
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NR 78
TC 35
Z9 38
U1 0
U2 7
PU AMER PHYSIOLOGICAL SOC
PI Rockville
PA 6120 Executive Blvd, Suite 600, Rockville, MD, UNITED STATES
SN 0363-6135
EI 1522-1539
J9 AM J PHYSIOL-HEART C
JI Am. J. Physiol.-Heart Circul. Physiol.
PD DEC
PY 2018
VL 315
IS 6
BP H1735
EP H1747
DI 10.1152/ajpheart.00218.2018
PG 13
WC Cardiac & Cardiovascular Systems; Physiology; Peripheral Vascular
   Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Physiology
GA HD7OJ
UT WOS:000452742500022
OA Bronze
DA 2025-06-11
ER

PT J
AU Leiria, LO
   Sollon, C
   Báu, FR
   Mónica, FZ
   D'Ancona, CL
   De Nucci, G
   Grant, AD
   Anhê, GF
   Antunes, E
AF Leiria, Luiz O.
   Sollon, Carolina
   Bau, Fernando R.
   Monica, Fabiola Z.
   D'Ancona, Carlos L.
   De Nucci, Gilberto
   Grant, Andrew D.
   Anhe, Gabriel F.
   Antunes, Edson
TI Insulin relaxes bladder via PI3K/AKT/eNOS pathway activation in mucosa:
   unfolded protein response-dependent insulin resistance as a cause of
   obesity-associated overactive bladder (Publication with Expression of
   Concern. See DEC, 2024)
SO JOURNAL OF PHYSIOLOGY-LONDON
LA English
DT Article; Publication with Expression of Concern
ID URINARY-TRACT SYMPTOMS; NITRIC-OXIDE SYNTHASE; EARLY LACTATING RATS;
   METABOLIC SYNDROME; ENDOTHELIAL DYSFUNCTION; ERECTILE DYSFUNCTION; AKT
   PHOSPHORYLATION; SIGNALING PATHWAYS; RISK-FACTOR; ER STRESS
AB We aimed to investigate the role of insulin in the bladder and its relevance for the development of overactive bladder (OAB) in insulin-resistant obese mice. Bladders from male individuals who were involved in multiple organ donations were used. C57BL6/J mice were fed with a high-fat diet for 10 weeks to induce insulin-resistant obesity. Concentrationresponse curves to insulin were performed in human and mouse isolated mucosa-intact and mucosa-denuded bladders. Cystometric study was performed in terminally anaesthetized mice. Western blot was performed in bladders to detect phosphorylated endothelial NO synthase (eNOS) (Ser1177) and the phosphorylated protein kinase AKT (Ser473), as well as the unfolded protein response (UPR) markers TRIB3, CHOP and ATF4. Insulin (1100 nm) produced concentration-dependent mouse and human bladder relaxations that were markedly reduced by mucosal removal or inhibition of the PI3K/AKT/eNOS pathway. In mouse bladders, insulin produced a 3.0-fold increase in cGMP levels (P < 0.05) that was prevented by PI3K/AKT/eNOS pathway inhibition. Phosphoinositide 3-kinase (PI3K) inhibition abolished insulin-induced phosphorylation of AKT and eNOS in bladder mucosa. Obese mice showed greater voiding frequency and non-voiding contractions, indicating overactive detrusor smooth muscle. Insulin failed to relax the bladder or to increase cGMP in the obese group. Insulin-stimulated AKT and eNOS phosphorylation in mucosa was also impaired in obese mice. The UPR markers TRIB3, CHOP and ATF4 were increased in the mucosa of obese mice. The UPR inhibitor 4-phenyl butyric acid normalized all the functional and molecular parameters in obese mice. Our data show that insulin relaxes human and mouse bladder via activation of the PI3K/AKT/eNOS pathway in the bladder mucosa. Endoplasmic reticulum stress-dependent insulin resistance in bladder contributes to OAB in obese mice.
C1 [Leiria, Luiz O.; Sollon, Carolina; Bau, Fernando R.; Monica, Fabiola Z.; De Nucci, Gilberto; Anhe, Gabriel F.; Antunes, Edson] Univ Estadual Campinas, UNICAMP, Fac Med Sci, Dept Pharmacol, Sao Paulo, Brazil.
   [D'Ancona, Carlos L.] Univ Estadual Campinas, UNICAMP, Fac Med Sci, Div Urol, Sao Paulo, Brazil.
   [Grant, Andrew D.] Kings Coll London, Wolfson Ctr Age Related Dis, London WC2R 2LS, England.
C3 Universidade Estadual de Campinas; Universidade Estadual de Campinas;
   University of London; King's College London
RP Antunes, E (corresponding author), Univ Campinas UNICAMP, Fac Med Sci, Dept Pharmacol, BR-13084971 Campinas, SP, Brazil.
EM edson.antunes@uol.com.br
RI Leiria, Luiz/ADQ-1873-2022; Bau, Fernando/JXL-7986-2024; Anhe,
   Gabriel/C-1980-2012; Antunes, Edson/KRP-5678-2024; De Nucci,
   Gilberto/J-5990-2012; Grant, Andrew/A-8819-2008; Monica,
   Fabiola/B-4191-2013; ANTUNES, EDSON/F-6731-2012
OI Anhe, Gabriel/0000-0002-7694-8397; De Nucci,
   Gilberto/0000-0002-4346-7941; Grant, Andrew/0000-0002-7032-3716; Monica,
   Fabiola/0000-0002-8449-6677; ANTUNES, EDSON/0000-0003-2201-8247
FU Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP); BBSRC
   [BB/E527098/1] Funding Source: UKRI
FX L.O.L. and E.A. thank Fundacao de Amparo a Pesquisa do Estado de Sao
   Paulo (FAPESP) for financial support.
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NR 52
TC 43
Z9 44
U1 1
U2 20
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-3751
EI 1469-7793
J9 J PHYSIOL-LONDON
JI J. Physiol.-London
PD MAY
PY 2013
VL 591
IS 9
BP 2259
EP 2273
DI 10.1113/jphysiol.2013.251843
PG 15
WC Neurosciences; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Physiology
GA 135OY
UT WOS:000318299200009
PM 23478138
OA Green Published
DA 2025-06-11
ER

PT J
AU Wu, L
   Li, X
   Zhu, HG
   Xu, P
   Gao, X
AF Wu, Lin
   Li, Xiang
   Zhu, Hongguang
   Xu, Ping
   Gao, Xin
TI A Prescribed Chinese Herbal Medicine Improves Glucose Profile and
   Ameliorates Oxidative Stress in Goto-Kakisaki Rats Fed with High Fat
   Diet
SO PLOS ONE
LA English
DT Article
ID BETA-CELLS; ENDOTHELIAL FUNCTION; METABOLIC SYNDROME; INSULIN-SECRETION;
   DIABETIC-RATS; ANTIOXIDANT; OBESITY; DYSFUNCTION; TETRAMETHYLPYRAZINE;
   INFLAMMATION
AB Oxidative stress (OS) plays a role in hyperglycemia induced islet beta cell dysfunction, however, studies on classic anti-oxidants didn't show positive results in treating diabetes. We previously demonstrated that the prescribed Chinese herbal medicine preparation "Qing Huo Yi Hao'' (QHYH) improved endothelial function in type 2 diabetic patients. QHYH protected endothelial cells from high glucose-induced damages by scavenging superoxide anion and reducing production of reactive oxygen species. Its active component protected C2C12 myotubes against palmitate-induced oxidative damage and mitochondrial dysfunction. In the present study, we investigated whether QHYH protected islet beta cell function exacerbated by high fat diet (HFD) in hyperglycemic GK rats. 4-week-old male rats were randomly divided into high HFD feeding group (n = 20) and chow diet feeding group (n = 10). Each gram of HFD contained 4.8 kcal of energy, 52% of which from fat. Rats on HFD were further divided into 2 groups given either QHYH (3 ml/Kg/d) or saline through gastric tube. After intervention, serum glucose concentrations were monitored; IPGTTs were performed without anesthesia on 5 fasting rats randomly chosen from each group on week 4 and 16. Serum malondialdehyde (MDA) concentrations and activities of serum antioxidant enzymes were measured on week 4 and 16. Islet beta cell mass and OS marker staining was done by immunohistochemistry on week 16. QHYH prevented the exacerbation of hyperglycemia in HFD feeding GK rats for 12 weeks. On week 16, it improved the exacerbated glucose tolerance and prevented the further loss of islet beta cell mass induced by HFD. QHYH markedly decreased serum MDA concentration, increased serum catalase (CAT) and SOD activities on week 4. However, no differences of serum glucose concentration or OS were observed on week 16. We concluded that QHYH decreased hyperglycemia exacerbated by HFD in GK rats by improving beta cell function partly via its antioxidant effect.
C1 [Li, Xiang; Gao, Xin] Fudan Univ, Zhongshan Hosp, Dept Endocrinol & Metab, Shanghai 200433, Peoples R China.
   [Wu, Lin] Fudan Univ, Zhongshan Hosp, Dept Geriatr, Shanghai 200433, Peoples R China.
   [Zhu, Hongguang] Fudan Univ, Dept Pathol, Shanghai Med Coll, Shanghai 200433, Peoples R China.
   [Xu, Ping] Chinese Acad Sci, Shanghai Lab Anim Ctr, Shanghai, Peoples R China.
C3 Fudan University; Fudan University; Fudan University; Chinese Academy of
   Sciences
RP Gao, X (corresponding author), Fudan Univ, Zhongshan Hosp, Dept Endocrinol & Metab, Shanghai 200433, Peoples R China.
EM gao.xin@zs-hospital.sh.cn
FU National Basic Research Program of China [2012CB524906, 2011CB504004];
   National Natural Science Foundation of China [30871196]; Specialized
   Research Fund for the Doctoral Program of Higher Education [20060246076]
FX This work was supported by: 1. Grants from the National Basic Research
   Program of China (2012CB524906 and 2011CB504004 to XG) (www.973.gov.cn);
   2. The National Natural Science Foundation of China (No 30871196 to XG)
   (www.nsfc.gov.cn); 3. Specialized Research Fund for the Doctoral Program
   of Higher Education (20060246076 to XG) (www.cutech.edu.cn). The funders
   had no role in study design, data collection and analysis, decision to
   publish, or preparation of the manuscript.
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NR 39
TC 2
Z9 2
U1 1
U2 38
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD APR 2
PY 2013
VL 8
IS 4
AR e60262
DI 10.1371/journal.pone.0060262
PG 10
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 127RY
UT WOS:000317717300083
PM 23565214
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Jiang, FR
   Qian, JC
   Chen, SY
   Zhang, WB
   Liu, C
AF Jiang, Fengrong
   Qian, Jinchun
   Chen, Siyu
   Zhang, Wenbo
   Liu, Chang
TI Ligustrazine improves atherosclerosis in rat via attenuation of
   oxidative stress
SO PHARMACEUTICAL BIOLOGY
LA English
DT Article
ID CORONARY HEART-DISEASE; HIGH-DENSITY LIPOPROTEIN;
   CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; ENDOTHELIAL-CELLS; NAD(P)H
   OXIDASE; TETRAMETHYLPYRAZINE; CHOLESTEROL; ALPHA; ASSOCIATION
AB Objective: The anti-atherosclerotic activities of Lig are evaluated in vivo for the first time in the present study.
   Materials and methods: We gave rats a single injection of vitamin D3 and then fed them with an atherogenic diet for 6 weeks to induce atherosclerosis. Lig was simultaneously given to rats by gavage at the dose of 20 or 80 mg/kg in the therapy groups. Multiple approaches including spectrophotometry, hematoxylin and eosin (H&E) staining, and quantitative RT-PCR were applied to investigate the effects of Lig on blood parameters, aorta and liver histology, and gene expression. In addition, the solely effects of Lig on food intake, body weight gain, and taste preference were also evaluated.
   Results: We found that two doses of Lig treatment decreased the total cholesterol levels by 65.2 and 76.7%, respectively, in the plasma. Triglyceride (by 53.2 and 77.9%) and low-density lipoprotein (by 71.2 and 79.0%) levels were also decreased. However, high-density lipoprotein level was slightly increased. The circulating endothelial cells were decreased by 42.2 and 60.0% in Lig-treated rats, indicating the attenuation of endothelial injury. In contrast, Lig restored the total antioxidant capacity and superoxide dismutase 1 (SOD1) activity while decreasing the MDA generation. Furthermore, Lig improved liver dysfunction by decreasing ALT (by 13.0 and 49.7%) and AST (by 10.7 and 14.3%) levels. Histological examinations revealed that Lig suppressed atherosclerotic plaque progression in the thoracic aorta and lipid accumulation in the liver. At the transcriptional level, Lig inhibited the induction of antioxidant genes both in aorta and in liver. Lig also suppressed the mRNA expression of the genes involved in the hepatic fatty acid oxidation. Finally, Lig had a minimum effect on food intake, body weight gain, and taste preference.
   Discussion and conclusion: Our results suggest that Lig suppresses the development of atherosclerosis and hepatic lipid accumulation via the alleviation of oxidative stress and the improvement of dyslipidemia.
C1 [Jiang, Fengrong; Qian, Jinchun; Chen, Siyu; Zhang, Wenbo; Liu, Chang] Nanjing Normal Univ, Jiangsu Key Lab Mol & Med Biotechnol, Nanjing, Peoples R China.
   [Jiang, Fengrong] Nanjing Univ Tradit Chinese Med, Coll Pharm, Nanjing, Peoples R China.
C3 Nanjing Normal University; Nanjing University of Chinese Medicine
RP Liu, C (corresponding author), Nanjing Normal Univ, Jiangsu Key Lab Mol & Med Biotechnol, Nanjing, Peoples R China.
EM changliu@njnu.edu.cn
OI Chen, Siyu/0000-0002-3809-1062
FU National Science Foundation of China [30870928]; Research Fund for the
   Doctoral Program of Higher Education of China [20103207110007]; Fok Ying
   Tong Education Foundation [121022]; Natural Science Foundation of the
   Jiangsu Higher Education Institutions of China [09KJA180004]; Jiangsu
   Key Laboratory for Molecular and Medical Biotechnology [MMB09KF05]
FX This work was supported by grants from the the National Science
   Foundation of China (30870928), the Research Fund for the Doctoral
   Program of Higher Education of China (20103207110007), the Fok Ying Tong
   Education Foundation (121022), the Natural Science Foundation of the
   Jiangsu Higher Education Institutions of China (09KJA180004), and the
   Opening Project of Jiangsu Key Laboratory for Molecular and Medical
   Biotechnology (MMB09KF05).
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NR 35
TC 63
Z9 77
U1 1
U2 28
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1388-0209
EI 1744-5116
J9 PHARM BIOL
JI Pharm. Biol.
PD AUG
PY 2011
VL 49
IS 8
BP 856
EP 863
DI 10.3109/13880209.2010.551776
PG 8
WC Plant Sciences; Medical Laboratory Technology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Medical Laboratory Technology; Pharmacology & Pharmacy
GA 782ER
UT WOS:000291991500015
PM 21554147
DA 2025-06-11
ER

PT J
AU Qu, AJ
   Jiang, CT
   Xu, MJ
   Zhang, Y
   Zhu, Y
   Xu, QB
   Zhang, CY
   Wang, X
AF Qu, Aijuan
   Jiang, Changtao
   Xu, Mingjiang
   Zhang, Yan
   Zhu, Yi
   Xu, Qingbo
   Zhang, Chenyu
   Wang, Xian
TI PGC-1α attenuates neointimal formation via inhibition of vascular smooth
   muscle cell migration in the injured rat carotid artery
SO AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
LA English
DT Article
DE restenosis; antioxidants; smooth muscle cells; metabolic syndrome;
   peroxisome proliferator-activated receptor-gamma coactivator-1 alpha
ID KAPPA-B ACTIVATION; MITOCHONDRIAL BIOGENESIS; ENDOTHELIAL-CELLS; PGC-1
   COACTIVATORS; ENERGY-METABOLISM; OXIDATIVE STRESS; GENE-EXPRESSION;
   GROWTH; MECHANISMS; DISEASE
AB Qu A, Jiang C, Xu M, Zhang Y, Zhu Y, Xu Q, Zhang C, Wang X. PGC-1 alpha attenuates neointimal formation via inhibition of vascular smooth muscle cell migration in the injured rat carotid artery. Am J Physiol Cell Physiol 297: C645-C653, 2009. First published June 24, 2009; doi:10.1152/ajpcell.00469.2008.-Oxidative stress contributes significantly to the migration of vascular smooth muscle cells (VSMCs), the major pathogenic process of vascular diseases, but the mechanism remains unclear. In the present study, we explored the role of peroxisome proliferator-activated receptor-gamma coactivator-1 alpha (PGC-1 alpha), a major regulator of mitochondrial biogenesis and energy balance, in VSMC migration in vitro and in vivo. Overexpression of PGC-1 alpha in cultured VSMCs led to a 74.5% reduction of migration activity and mitochondrial ROS generation by the increased expression of antioxidative proteins such as SOD-2 in the mitochondria. The knockdown of PGC-1 alpha by specific small interfering (si)RNA markedly augmented VSMC migration activity and greatly reduced mitochondrial antioxidative protein expression. Furthermore, knockdown of SOD-2 expression by siRNA greatly reversed the inhibitory effect of PGC-1 alpha overexpression on VSMC migration. In a rat carotid balloon injury model, adenovirus-mediated overexpression of PGC-1 alpha greatly reduced neointimal formation (ratio of intima to media: 0.78 +/- 0.09 vs. 1.45 +/- 0.18 in the adenovirus + green fluorescent protein gene-transfected group). Moreover, the expression of SOD-2 was significantly increased in vivo in local vessels after injury in the PGC-1 alpha-overexpressing group. These data strongly suggest that PGC-1 alpha inhibits VSMC migration and neointimal formation after vascular injury in rats, mainly by upregulating the expression of the mitochondrial antioxidant enzyme SOD-2.
C1 [Qu, Aijuan; Jiang, Changtao; Xu, Mingjiang; Zhu, Yi; Wang, Xian] Peking Univ, Dept Physiol & Pathophysiol, Sch Basic Med Sci, Key Lab Mol Cardiovas Sci,Minist Educ, Beijing 100191, Peoples R China.
   [Zhang, Yan; Zhang, Chenyu] Nanjing Univ, Sch Life Sci, State Key Lab Pharmaceut Biotechnol, Jiangsu Diabet Ctr, Nanjing 210008, Peoples R China.
   [Xu, Qingbo] Kings Coll London, James Black Ctr, Div Cardiovasc, London WC2R 2LS, England.
C3 Ministry of Education - China; Peking University; Nanjing University;
   University of London; King's College London
RP Wang, X (corresponding author), Peking Univ, Dept Physiol & Pathophysiol, Sch Basic Med Sci, Key Lab Mol Cardiovas Sci,Minist Educ, Beijing 100191, Peoples R China.
EM cyzhang@nju.edu.cn; xwang@bjmu.edu.cn
RI , ZhangCY/JSK-5704-2023; Jiang, Changtao/LSI-7413-2024
OI Jiang, Changtao/0000-0002-5206-2372
FU Major National Basic Research Program of the People's Republic of China
   [2006CB503802]; National Natural Science Foundation of the People's
   Repulbic of China [30821001]; Key Grant Project of Chinese Ministry of
   Education [307001]; Chang Jiang Scholars Program
FX This work was supported by Major National Basic Research Program of the
   People's Republic of China Grant 2006CB503802, National Natural Science
   Foundation of the People's Repulbic of China Grant 30821001, Key Grant
   Project of Chinese Ministry of Education Grant 307001 (to X. Wang), and
   the Chang Jiang Scholars Program (to Q. Xu).
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NR 40
TC 33
Z9 39
U1 1
U2 7
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0363-6143
EI 1522-1563
J9 AM J PHYSIOL-CELL PH
JI Am. J. Physiol.-Cell Physiol.
PD SEP
PY 2009
VL 297
IS 3
BP C645
EP C653
DI 10.1152/ajpcell.00469.2008
PG 9
WC Cell Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Physiology
GA 491MX
UT WOS:000269584200017
PM 19553562
DA 2025-06-11
ER

PT J
AU Mills, PJ
   Ancoli-Israel, S
   von Känel, R
   Mausbach, BT
   Aschbacher, K
   Patterson, TL
   Ziegler, MG
   Dimsdale, JE
   Grant, I
AF Mills, Paul J.
   Ancoli-Israel, Sonia
   von Kaenel, Roland
   Mausbach, Brent T.
   Aschbacher, Kirstin
   Patterson, Thomas L.
   Ziegler, Michael G.
   Dimsdale, Joel E.
   Grant, Igor
TI Effects of gender and dementia severity on Alzheimer's disease
   caregivers' sleep and biomarkers of coagulation and inflammation
SO BRAIN BEHAVIOR AND IMMUNITY
LA English
DT Article
DE Alzheimer's disease; Caregiving; Gender; Sleep; Coagulation;
   Inflammation; D-dimer; IL-6
ID CORONARY-HEART-DISEASE; D-DIMER; NEUROPSYCHIATRIC INVENTORY;
   OSTEOPOROTIC FRACTURES; SPOUSAL CAREGIVERS; METABOLIC SYNDROME; OLDER
   WOMEN; POOR SLEEP; INTERLEUKIN-6; STRESS
AB Background: Being a caregiver for a spouse with Alzheimer's disease is associated with increased risk for cardiovascular illness, particularly for males. This study examined the effects of caregiver gender and severity of the spouse's dementia on sleep, coagulation, and inflammation in the caregiver.
   Methods: Eighty-one male and female spousal caregivers and 41 non-caregivers participated (mean age of all participants 70.2 years). Full-night polysomnography (PSG) was recorded in each participants home. Severity of the Alzheimer's disease patient's dementia was determined by the Clinical Dementia Rating (CDR) scale. The Role Overload scale was completed as an assessment of caregiving stress. Blood was drawn to assess circulating levels of D-dimer and Interleukin-6 (IL-6).
   Results: Male caregivers who were caring for a spouse with moderate to severe dementia spent significantly more time awake after sleep onset than female caregivers caring for spouses with moderate to severe dementia (p=.011), who spent a similar amount of time awake after sleep onset to caregivers of low dementia spouses and to non-caregivers. Similarly, male caregivers caring for spouses with worse dementia had significantly higher circulating levels of D-dimer (p=.034) than females caring for spouses with worse dementia. In multiple regression analysis (adjusted R(2)=.270, p<.001), elevated D-dimer levels were predicted by a combination of the CDR rating of the patient (p=.047) as well as greater time awake after sleep onset (p=.046).
   Discussion: The findings suggest that males caring for spouses with more severe dementia experience more disturbed sleep and have greater coagulation, the latter being associated with the disturbed sleep. These findings may provide insight into why male caregivers of spouses with Alzheimer's disease are at increased risk for illness, particularly cardiovascular disease. (C) 2008 Elsevier Inc. All rights reserved.
C1 [Mills, Paul J.; Ancoli-Israel, Sonia; von Kaenel, Roland; Mausbach, Brent T.; Aschbacher, Kirstin; Patterson, Thomas L.; Dimsdale, Joel E.; Grant, Igor] Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA.
   [Ancoli-Israel, Sonia; Patterson, Thomas L.; Grant, Igor] San Diego Vet Affairs Healthcare Syst, La Jolla, CA USA.
   [von Kaenel, Roland] Univ Hosp Bern, Dept Gen Internal Med, Bern, Switzerland.
   [Ziegler, Michael G.] Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA.
C3 University of California System; University of California San Diego;
   University of Bern; University Hospital of Bern; University of
   California System; University of California San Diego
RP Mills, PJ (corresponding author), Univ Calif San Diego, Dept Psychiat, 9500 Gilman Dr, La Jolla, CA 92093 USA.
EM pmills@ucsd.edu
RI Ziegler, Michael/L-4728-2019; von Kanel, Roland/B-1811-2019
OI Mausbach, Brent/0000-0003-2884-8743; von Kanel,
   Roland/0000-0002-8929-5129
FU National Institute on Aging [05131, 08415, 23989]; National Center for
   Research Resources [HL57265, M01 RR00827]
FX Funding/Support: Supported by awards 05131, 08415, 05131, and 23989 from
   the National Institute on Aging, HL57265, and award M01 RR00827 from the
   National Center for Research Resources. The authors report no conflicts
   of interest.
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NR 40
TC 61
Z9 83
U1 0
U2 18
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0889-1591
J9 BRAIN BEHAV IMMUN
JI Brain Behav. Immun.
PD JUL
PY 2009
VL 23
IS 5
SI SI
BP 605
EP 610
DI 10.1016/j.bbi.2008.09.014
PG 6
WC Immunology; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Immunology; Neurosciences & Neurology; Psychiatry
GA 461NL
UT WOS:000267274000006
PM 18930805
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Sparks, JD
   O'Dell, C
   Chamberlain, JM
   Sparks, CE
AF Sparks, Janet D.
   O'Dell, Colleen
   Chamberlain, Jeffrey M.
   Sparks, Charles E.
TI Insulin-dependent apolipoprotein B degradation is mediated by autophagy
   and involves class I and class III phosphatidylinositide 3-kinases
SO BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
LA English
DT Article
DE Apo B; Autophagy; PI3K; Vps34; Thapsigargin; PTEN; VLDL; Liver
ID LOW-DENSITY LIPOPROTEINS; RAT HEPATOCYTES; APO-B; ENDOPLASMIC-RETICULUM;
   METABOLIC SYNDROME; TUMOR-SUPPRESSOR; PRIMARY CULTURES; INHIBITION;
   SECRETION; OVERPRODUCTION
AB Insulin acutely stimulates the degradation of apolipoprotein B (apo B) which decreases very low density lipoprotein (VLDL) secretion by liver. Insulin-dependent apo B degradation (IDAD) occurs following phosphatidylinositide 3-kinase (PI3K) activation and involves lysosomal degradation. Insulin suppression of apo B secretion is blocked by over-expression of phosphatase and tensin homologue (PTEN) in McArdle RH7777 (McA) cells suggesting the importance of Class I PI3K generated PI (3,4,5) triphosphate (PIP3) in IDAD. Classical autophagy inhibitors including 3-methyladenine, L-asparagine and bafilomycin A1 also blocked the ability of insulin to suppress apo B secretion by rat hepatocytes (RH) suggesting that IDAD occurs through an autophagy-related mechanism. IDAD is also blocked following over-expression in McA cells of a dominant negative kinase-defective Vps34, a class III PI3K that generates PI 3-monophosphate required for autophagy. Vps34 inhibition of IDAD occurs without altering insulin-dependent S473 phosphorylation of Akt indicating PI3K/PIP3/Akt signaling is intact. Cellular p62/SQSTM1, an inverse indicator of autophagy, is increased with insulin treatment consistent with the known ability of insulin to inhibit autophagy, and therefore the role of insulin in utilizing components of autophagy for apo B degradation is unexpected. Thapsigargan, an inducer of endoplasmic reticulum (ER) stress, and a recently demonstrated autophagy inhibitor, blocked apo B secretion which contrasted with other autophagy inhibitors and mutant Vps34 results which were permissive with respect to apo B secretion. Pulse chase studies indicated that intact B100 and B48 proteins were retained in cells treated with thapsigargan consistent with their accumulation in autophagosomal vacuoles. Differences between IDAD and ER stress-coupled autophagy mediated by thapsgargin suggest that IDAD involves an unique form of autophagy. Insulin action resulting in hepatic apo B degradation is novel and important in understanding regulation of hepatic VLDL metabolism. (C) 2013 Elsevier Inc. All rights reserved.
C1 [Sparks, Janet D.; O'Dell, Colleen; Chamberlain, Jeffrey M.; Sparks, Charles E.] Univ Rochester, Med Ctr, Dept Pathol & Lab Med, Rochester, NY 14642 USA.
C3 University of Rochester
RP Sparks, JD (corresponding author), Univ Rochester, Med Ctr, Dept Pathol & Lab Med, Box 626,601 Elmwood Ave, Rochester, NY 14642 USA.
EM Janet_Sparks@urmc.rochester.edu
OI Sparks, Janet/0000-0002-0072-766X; O'Dell, Colleen/0009-0009-1333-6623
FU NIDDK NIH HHS [R01 DK100163] Funding Source: Medline
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NR 39
TC 16
Z9 20
U1 0
U2 11
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0006-291X
J9 BIOCHEM BIOPH RES CO
JI Biochem. Biophys. Res. Commun.
PD JUN 14
PY 2013
VL 435
IS 4
BP 616
EP 620
DI 10.1016/j.bbrc.2013.05.029
PG 5
WC Biochemistry & Molecular Biology; Biophysics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics
GA 172SS
UT WOS:000321025800019
PM 23685141
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Zhou, J
   Wang, SS
   Wang, Q
   Zhao, R
   Wang, DX
   Xie, HH
   Du, YT
   Xu, Y
   Deng, J
   Huang, Y
   Liu, YH
   Peng, XL
   Hao, LP
   Liu, LG
AF Zhou, Juan
   Wang, Shanshan
   Wang, Qiang
   Zhao, Rui
   Wang, Dongxia
   Xie, Huihui
   Du, Yatan
   Xu, Yue
   Deng, Jin
   Huang, Yue
   Liu, Yuanhua
   Peng, Xiaolin
   Hao, Liping
   Liu, Liegang
TI Effect of lutein supplementation on blood lipids and advanced glycation
   end products in adults with central obesity: a double-blind randomized
   controlled trial
SO FOOD & FUNCTION
LA English
DT Article
ID METABOLIC SYNDROME; OXIDATIVE STRESS; BASE-LINE; ASSOCIATION; HEALTHY;
   ENDPRODUCTS; LYCOPENE
AB Central obesity poses a significant health threat. Lutein-rich fruits and vegetables may help manage obesity. Limited evidence suggests that lutein exerts health effects by inhibiting advanced glycation end products (AGEs), but data on its effects in centrally obese individuals are sparse. Thus, we aimed to investigate the effects of lutein supplementation in subjects with central obesity. A double-blind, randomized controlled trial was conducted involving patients with central obesity. Anthropometric indices, dietary intake, metabolic parameters, carotenoid and AGEs levels were compared between those receiving a 32-week intervention of 10 mg d(-1) lutein and a placebo group. There were 117 patients randomly assigned in the analysis. Twenty-three patients were lost to follow-up. Both intention-to-treat analysis and the per-protocol analysis showed significant reductions in plasma total cholesterol, low-density lipoprotein cholesterol, apolipoprotein B, and malonaldehyde levels in the lutein supplementation group compared with the placebo group. Significant differences were also observed between the groups in plasma lutein, carboxyethyl lysine (CEL), carboxymethyl lysine (CML), methylglyoxal hydroimidazolone (MG-HI) levels and skin carotenoid index (all P < 0.05). The mean difference and 95% confidence interval were 0.12 [0.08 to 0.16] mu g ml(-1), -8.76 [-16.60 to -0.89] ng ml(-1), -72.3 [-134.0 to -10.9] ng ml(-1), -233.9 [-429.0 to -36.8] ng ml(-1) and 0.94 [0.56 to 1.31] a.u., respectively. Furthermore, changes in plasma lutein concentration were positively correlated with changes in the skin carotenoid index (r = 0.41, P < 0.001), and negatively correlated with changes in plasma CEL (r = -0.24, P = 0.018), (CML) (r = -0.21, P = 0.051, and MG-H1) (r = -0.25, P = 0.017). In conclusion, regular lutein intake can improve metabolic health in adults with central obesity by increasing plasma lutein concentrations, reducing oxidative stress, lowering plasma TC, LDL-C, and ApoB levels, and downregulating AGEs.
C1 [Zhou, Juan; Wang, Shanshan; Wang, Qiang; Zhao, Rui; Wang, Dongxia; Xie, Huihui; Du, Yatan; Xu, Yue; Deng, Jin; Huang, Yue; Hao, Liping; Liu, Liegang] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Dept Nutr & Food Hyg, 13 Hangkong Rd, Wuhan 430030, Peoples R China.
   [Zhou, Juan; Wang, Shanshan; Wang, Qiang; Zhao, Rui; Wang, Dongxia; Xie, Huihui; Du, Yatan; Xu, Yue; Deng, Jin; Huang, Yue; Hao, Liping; Liu, Liegang] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Hubei Key Lab Food Nutr & Safety, Wuhan, Peoples R China.
   [Zhou, Juan; Wang, Shanshan; Wang, Qiang; Zhao, Rui; Wang, Dongxia; Xie, Huihui; Du, Yatan; Xu, Yue; Deng, Jin; Huang, Yue; Hao, Liping; Liu, Liegang] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Minist Educ Key Lab Environm & Hlth, Wuhan, Peoples R China.
   [Liu, Yuanhua] Sun Yat Sen Univ, Sch Publ Hlth, Dept Nutr, Guangzhou, Guangdong, Peoples R China.
   [Peng, Xiaolin] Shenzhen Nanshan Ctr Chron Dis Control, Dept Oncol Injury Prevent & Nutr, Shenzhen, Peoples R China.
C3 Huazhong University of Science & Technology; Huazhong University of
   Science & Technology; Huazhong University of Science & Technology; Sun
   Yat Sen University; Shenzhen Nanshan Center for Chronic Disease Control
RP Hao, LP (corresponding author), Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Dept Nutr & Food Hyg, 13 Hangkong Rd, Wuhan 430030, Peoples R China.; Hao, LP (corresponding author), Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Hubei Key Lab Food Nutr & Safety, Wuhan, Peoples R China.; Hao, LP (corresponding author), Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Minist Educ Key Lab Environm & Hlth, Wuhan, Peoples R China.; Peng, XL (corresponding author), Shenzhen Nanshan Ctr Chron Dis Control, Dept Oncol Injury Prevent & Nutr, Shenzhen, Peoples R China.
EM xiaolinpeng@hotmail.com; haolp@mails.tjmu.edu.cn
RI wang, dongxia/LUZ-7548-2024
FU Chinese Nutrition Society [81573149]; National Natural Science
   Foundation of China [2018A34]; Chinese Nutrition Society Nutrition
   Research Foundation-DSM Research Fund [SZSJ2017001]; Project Fund of the
   Health and Family Commission of Shenzhen Municipality [FNS-HBKL2022A02];
   Hubei Key Laboratory of Food Nutrition and Safety (Huazhong University
   of Science and Technology); Shenzhen Nanshan Center for Chronic Disease
   Control
FX This work was supported by grants from the National Natural Science
   Foundation of China (No. 81573149), Chinese Nutrition Society Nutrition
   Research Foundation-DSM Research Fund (No. 2018A34), Project Fund of the
   Health and Family Commission of Shenzhen Municipality (No. SZSJ2017001),
   and Hubei Key Laboratory of Food Nutrition and Safety (Huazhong
   University of Science and Technology, Grant number FNS-HBKL2022A02). The
   findings and conclusions of this article are solely the responsibility
   of the authors and do not represent the official views of the above
   funder. We would like to express our gratitude to all participants for
   their cooperation. We also grateful to all staff of health service
   centers and Shenzhen Nanshan Center for Chronic Disease Control for
   their considerable assistance.
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NR 47
TC 2
Z9 2
U1 2
U2 2
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PD MAR 3
PY 2025
VL 16
IS 5
BP 2096
EP 2107
DI 10.1039/d4fo05578k
EA FEB 2025
PG 12
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA Z1V6V
UT WOS:001424374500001
PM 39964702
DA 2025-06-11
ER

PT J
AU Giona, L
   Musillo, C
   De Cristofaro, G
   Ristow, M
   Zarse, K
   Siems, K
   Tait, S
   Cirulli, F
   Berry, A
AF Giona, Letizia
   Musillo, Chiara
   De Cristofaro, Gaia
   Ristow, Michael
   Zarse, Kim
   Siems, Karsten
   Tait, Sabrina
   Cirulli, Francesca
   Berry, Alessandra
TI Western diet-induced cognitive and metabolic dysfunctions in aged mice
   are prevented by rosmarinic acid in a sex-dependent fashion
SO CLINICAL NUTRITION
LA English
DT Article
DE Rosmarinic acid; Metabolic syndrome; Aging; Cognitive dysfunction;
   Mouse; Sex differences
ID OXIDATIVE STRESS; NEUROPEPTIDE-S; MOUSE MODEL; HIPPOCAMPAL;
   EVOLUTIONARY; SENSITIVITY; RESISTANCE; DELETION; HORMONES
AB Background & aims: Unhealthy lifestyles, such as chronic consumption of a Western Diet (WD), have been associated with increased systemic inflammation and oxidative stress (OS), a condition that may favour cognitive dysfunctions during aging. Polyphenols, such as rosmarinic acid (RA) may buffer lowgrade inflammation and OS, characterizing the aging brain that is sustained by WD, promoting healthspan. The aim of this study was to evaluate the ability of RA to prevent cognitive decline in a mouse model of WD-driven unhealthy aging and to gain knowledge on the specific molecular pathways modulated within the brain. Methods: Aged male and female C57Bl/6N mice were supplemented either with RA or vehicle for 6 weeks. Following 2 weeks on RA they started being administered either with WD or control diet (CD). Successively all mice were tested for cognitive abilities in the Morris water maze (MWM) and emotionality in the elevated plus maze (EPM). Glucose and lipid homeostasis were assessed in trunk blood while the hippocampus was dissected out for RNAseq transcriptomic analysis. Results: RA prevented insulin resistance in males while protecting both males and females from WDdependent memory impairment. In the hippocampus, RA modulated OS pathways in males and immune- and sex hormones-related signalling cascades (Lhb and Lhcgr genes) in females. Moreover, RA overall resulted in an upregulation of Glp1r, recently identified as a promising target to prevent metabolic derangements. In addition, we also found an RA-dependent enrichment in nuclear transcription factors, such as NF-KB, GR and STAT3, that have been recently suggested to promote healthspan and longevity by modulating inflammatory and cell survival pathways. Conclusions: Oral RA supplementation may promote brain and metabolic plasticity during aging through antioxidant and immune-modulating properties possibly affecting the post-reproductive hormonal milieu in a sex-dependent fashion. Thus, its supplementation should be considered in the context of precision medicine as a possible strategy to preserve cognitive functions and to counteract metabolic derangements.
C1 [Giona, Letizia; Musillo, Chiara; De Cristofaro, Gaia; Cirulli, Francesca; Berry, Alessandra] Ist Super Sanita, Ctr Behav Sci & Mental Hlth, Viale Regina Elena 299, I-00161 Rome, Italy.
   [Giona, Letizia] Univ Cattolica Sacro Cuore, Fac Med & Surg, Program Sci Nutr Metab Ageing & Gender Related Dis, Largo Francesco Vito 1, I-00168 Rome, Italy.
   [Ristow, Michael; Zarse, Kim] Charite Univ Med Berlin, Inst Expt Endocrinol & Diabetol, D-10117 Berlin, Germany.
   [Siems, Karsten] AnalytiCon Discovery GmbH, D-14473 Potsdam, Germany.
   [Tait, Sabrina] Ist Super Sanita, Ctr Gender Specif Med, Viale Regina Elena 299, I-00161 Rome, Italy.
C3 Istituto Superiore di Sanita (ISS); Catholic University of the Sacred
   Heart; IRCCS Policlinico Gemelli; Berlin Institute of Health; Free
   University of Berlin; Humboldt University of Berlin; Charite
   Universitatsmedizin Berlin; Istituto Superiore di Sanita (ISS)
RP Cirulli, F (corresponding author), Ist Super Sanita, Ctr Behav Sci & Mental Hlth, Viale Regina Elena 299, I-00161 Rome, Italy.
EM letizia.giona@guest.iss.it; chiara.musillo@iss.it;
   gaia.decristofaro1990@gmail.com; michael.ristow@charite.de;
   ki.zarse@charite.de; k.siems@ac-discovery.com; sabrina.tait@iss.it;
   francesca.cirulli@iss.it; alessandra.berry@iss.it
RI Musillo, Chiara/AAC-8035-2021; Berry, Alessandra/N-9280-2017; Tait,
   Sabrina/C-6071-2015; Giona, Letizia/LSL-6727-2024; Cirulli,
   Francesca/H-5992-2019; Zarse, Kim/D-2133-2016; Ristow,
   Michael/O-9858-2014
OI Musillo, Chiara/0000-0002-1760-7226; Berry,
   Alessandra/0000-0001-6562-9043; CIRULLI, Francesca/0000-0001-9440-1873;
   Zarse, Kim/0000-0003-2542-6123; Ristow, Michael/0000-0003-2109-2453;
   Giona, Letizia/0009-0008-0093-5080
FU Horizon 2020 Framework Programme; Swiss National Science Foundation
   (Schweizerischer National fonds, SNF) [31003A_156031, 31003A_176127,
   310030_204511]; H2020 AwE "Ageing with Elegans" [633589]; Swiss National
   Science Foundation (SNF) [310030_204511] Funding Source: Swiss National
   Science Foundation (SNF)
FX Funding for this research were provided by Horizon 2020 Framework
   Programme; H2020 AwE "Ageing with Elegans" [grant agreement N. 633589] .
   The Ristow lab was supported by the Swiss National Science Foundation
   (Schweizerischer National fonds, SNF 31003A_156031, 31003A_176127, and
   310030_204511) .
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NR 63
TC 4
Z9 4
U1 0
U2 2
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0261-5614
EI 1532-1983
J9 CLIN NUTR
JI Clin. Nutr.
PD OCT
PY 2024
VL 43
IS 10
BP 2236
EP 2248
DI 10.1016/j.clnu.2024.08.012
EA AUG 2024
PG 13
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA E2V5W
UT WOS:001301630600001
PM 39182436
OA hybrid
DA 2025-06-11
ER

PT J
AU Flores-Cortez, YA
   Barragan-Bonilla, MI
   Mendoza-Bello, JM
   Gonzalez-Calixto, C
   Flores-Alfaro, E
   Espinoza-Rojo, M
AF Flores-Cortez, Yaccil Adilene
   Barragan-Bonilla, Martha I.
   Mendoza-Bello, Juan M.
   Gonzalez-Calixto, Cecilia
   Flores-Alfaro, Eugenia
   Espinoza-Rojo, Monica
TI Interplay of retinol binding protein 4 with obesity and associated
   chronic alterations
SO MOLECULAR MEDICINE REPORTS
LA English
DT Review
DE retinol-binding protein 4; obesity; type 2 diabetes; oxidative stress;
   insulin resistance
ID VITAMIN-A METABOLISM; INSULIN-RESISTANCE; GENE-EXPRESSION;
   ADIPOSE-TISSUE; WEIGHT-LOSS; RBP4; INFLAMMATION; RECEPTORS; LEVEL; CELLS
AB Obesity is a multifactorial disease, defined as excessive fat deposition in adipose tissue. Adipose tissue is responsible for the production and secretion of numerous adipokines that induce metabolic disorders. Retinol-binding protein 4 (RBP4) is an adipokine that transports vitamin A or retinol in the blood. High levels of RBP4 are associated with development of metabolic disease, including obesity, insulin resistance (IR), metabolic syndrome, and type 2 diabetes (T2D). The present review summarizes the role of RBP4 in obesity and associated chronic alterations. Excessive synthesis of RBP4 contributes to inflammatory characteristic of obesity by activation of immune cells and release of proinflammatory cytokines, such as TNF alpha and ILs, via the Toll-like receptor/JNK pathway. The retinol-RBP4 complex inhibits insulin signaling directly in adipocytes by activating Janus kinase 2 (JAK2)/STAT5/suppressor of cytokine signaling 3 signaling. This mechanism is retinol-dependent and requires vitamin A receptor stimulation by retinoic acid 6 (STRA6). In muscle, RBP4 is associated with increased serine 307 phosphorylation of insulin receptor substrate-1, which decreases its affinity to PI3K and promotes IR. In the liver, RBP4 increases hepatic expression of phosphoenolpyruvate carboxykinase, which increases production of glucose. Elevated serum RBP4 levels are associated with beta-cell dysfunction in T2D via the STRA6/JAK2/STAT1/insulin gene enhancer protein 1 pathway. By contrast, RBP4 induces endothelial inflammation via the NF-kappa B/nicotinamide adenine dinucleotide phosphate oxidase pathway independently of retinol and STRA6, which stimulates expression of proinflammatory molecules, such as vascular cell adhesion molecule 1, E-selectin, intercellular adhesion molecule 1, monocyte chemoattractant protein 1 and TNF alpha. RBP4 promotes oxidative stress by decreasing endothelial mitochondrial function; overall, it may serve as a useful biomarker in the diagnosis of obesity and prognosis of associated disease, as well as a potential therapeutic target for treatment of these diseases.
C1 [Flores-Cortez, Yaccil Adilene; Barragan-Bonilla, Martha I.; Mendoza-Bello, Juan M.; Espinoza-Rojo, Monica] Autonomous Univ Guerrero, Fac Biol Chem Sci, Lab Mol Biol & Genom, Chilpancingo 39087, Guerrero, Mexico.
   [Gonzalez-Calixto, Cecilia] Autonomous Univ Guerrero, Fac Nursing, Acapulco 39610, Guerrero, Mexico.
   [Flores-Alfaro, Eugenia] Autonomous Univ Guerrero, Fac Biol & Chem Sci, Lab Clin & Mol Epidemiol, Chilpancingo 39087, Guerrero, Mexico.
   [Espinoza-Rojo, Monica] Autonomous Univ Guerrero, Fac Biol Chem Sci, Lab Mol Biol & Genom, Ave Lazaro Cardenas S-N,Ciudad Universitaria, Chilpancingo 39087, Guerrero, Mexico.
RP Espinoza-Rojo, M (corresponding author), Autonomous Univ Guerrero, Fac Biol Chem Sci, Lab Mol Biol & Genom, Chilpancingo 39087, Guerrero, Mexico.; Espinoza-Rojo, M (corresponding author), Autonomous Univ Guerrero, Fac Biol Chem Sci, Lab Mol Biol & Genom, Ave Lazaro Cardenas S-N,Ciudad Universitaria, Chilpancingo 39087, Guerrero, Mexico.
EM monicaespinozarojo2014@gmail.com
RI Mendoza-Bello, Juan Miguel/GPK-1256-2022; Barragán,
   Martha/JBI-7103-2023; Flores-Alfaro, Eugenia/O-1962-2017
OI Barragan Bonilla, Martha Isela/0000-0002-7399-8970; Flores Cortez,
   Yaccil Adilene/0000-0002-8698-1377; Flores-Alfaro,
   Eugenia/0000-0002-0816-8874
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NR 98
TC 37
Z9 38
U1 1
U2 14
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1791-2997
EI 1791-3004
J9 MOL MED REP
JI Mol. Med. Rep.
PD JUL
PY 2022
VL 26
IS 1
AR 244
DI 10.3892/mmr.2022.12760
PG 12
WC Oncology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Research & Experimental Medicine
GA 2D6WP
UT WOS:000811684900001
PM 35656886
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Wehrli, FW
   Caporale, A
   Langham, MC
   Chatterjee, S
AF Wehrli, Felix W.
   Caporale, Alessandra
   Langham, Michael C.
   Chatterjee, Shampa
TI New Insights From MRI and Cell Biology Into the Acute Vascular-Metabolic
   Implications of Electronic Cigarette Vaping
SO FRONTIERS IN PHYSIOLOGY
LA English
DT Review
DE E-cigarette; endothelium; MRI; vaping; vascular
ID PULSE-WAVE VELOCITY; FLOW-MEDIATED DILATATION; ENDOTHELIAL DYSFUNCTION;
   OXIDATIVE STRESS; NITRIC-OXIDE; LUNG INJURY; REPRODUCIBILITY;
   INFLAMMATION; SMOKING; DISEASE
AB The popularity of electronic cigarettes (e-cigs) has grown at a startling rate since their introduction to the United States market in 2007, with sales expected to outpace tobacco products within a decade. Spurring this trend has been the notion that e-cigs are a safer alternative to tobacco-based cigarettes. However, the long-term health impacts of e-cigs are not yet known. Quantitative magnetic resonance imaging (MRI) approaches, developed in the authors' laboratory, provide conclusive evidence of acute deleterious effects of e-cig aerosol inhalation in the absence of nicotine in tobacco-naive subjects. Among the pathophysiologic effects observed are transient impairment of endothelial function, vascular reactivity, and oxygen metabolism. The culprits of this response are currently not fully understood but are likely due to an immune reaction caused by the aerosol containing thermal breakdown products of the e-liquid, including radicals and organic aldehydes, with particle concentrations similar to those emitted by conventional cigarettes. The acute effects observed following a single vaping episode persist for 1-3 h before subsiding to baseline and are paralleled by build-up of biological markers. Sparse data exist on long-term effects of vaping, and it is likely that repeated regular exposure to e-cig aerosol during vaping will lead to chronic conditions since there would be no return to baseline conditions as in the case of an isolated vaping episode. This brief review aims to highlight the potential of pairing MRI, with its extraordinary sensitivity to structure, physiology and metabolism at the holistic level, with biologic investigations targeting serum and cellular markers of inflammation and oxidative stress. Such a multi-modal framework should allow interpretation of the impact of e-cigarette vaping on vascular health at the organ level in the context of the underlying biological alterations. Applications of this approach to the study of other lifestyle-initiated pathologies including hypertension, hypercholesterolemia, and metabolic syndrome are indicated.
C1 [Wehrli, Felix W.; Caporale, Alessandra; Langham, Michael C.] Univ Penn, Dept Radiol, Lab Struct Physiol & Funct Imaging, Philadelphia, PA 19104 USA.
   [Chatterjee, Shampa] Univ Penn, Dept Physiol, Philadelphia, PA 19104 USA.
   [Chatterjee, Shampa] Univ Penn, Inst Environm Med, Philadelphia, PA 19104 USA.
C3 University of Pennsylvania; University of Pennsylvania; University of
   Pennsylvania
RP Wehrli, FW (corresponding author), Univ Penn, Dept Radiol, Lab Struct Physiol & Funct Imaging, Philadelphia, PA 19104 USA.
EM felix.wehrli@pennmedicine.upenn.edu
RI Caporale, Alessandra/AAC-3404-2022
OI Caporale, Alessandra/0000-0002-2182-8312; Chatterjee,
   Shampa/0000-0003-3351-5580; Wehrli, Felix/0000-0003-3430-1840
FU National Institutes of Health, National Heart, Lung, and Blood Institute
   [R01HL139358]
FX Our research of which we report results published elsewhere (see
   specific references) was supported by the National Institutes of Health,
   National Heart, Lung, and Blood Institute (R01HL139358).
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NR 49
TC 4
Z9 5
U1 0
U2 6
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-042X
J9 FRONT PHYSIOL
JI Front. Physiol.
PD MAY 21
PY 2020
VL 11
AR 492
DI 10.3389/fphys.2020.00492
PG 8
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA LW9HS
UT WOS:000539453300001
PM 32528311
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Ramírez-Jiménez, R
   Martínez-Salazar, MF
   Almenares-López, D
   Yáñez-Estrada, L
   Monroy-Noyola, A
AF Ramirez-Jimenez, Rocio
   Fernanda Martinez-Salazar, Maria
   Almenares-Lopez, Damianys
   Yanez-Estrada, Leticia
   Monroy-Noyola, Antonio
TI Relationship Between Paraoxonase-1 and Butyrylcholinesterase Activities
   and Nutritional Status in Mexican Children
SO METABOLIC SYNDROME AND RELATED DISORDERS
LA English
DT Article
DE obesity; overweight; PON1 polymorphism; paraoxonase;
   butyrylcholinesterase
ID SYSTEMIC OXIDATIVE STRESS; PON1 GENE POLYMORPHISMS;
   LOW-DENSITY-LIPOPROTEIN; SERUM PARAOXONASE; LIPID PROFILE; ARYLESTERASE;
   OBESITY; ADIPOSITY; HEALTHY; RISK
AB Background: The enzymes butyrylcholinesterase (BuChE) and paraoxonase-1 (PON1) are the primary bioscavenging enzymes in serum and exhibit antioxidant and anti-inflammatory activities. PON1 has been associated with diseases caused by high oxidative stress, whereas BuChE appears to be involved in the pathophysiology of the metabolic syndrome and related disorders. It has been suggested that children from rural communities in Mexico may have a predisposition to develop obesity or type 2 diabetes during adolescence or adulthood. The objective of this study was to determine whether associations exist between the paraoxonase (PONase)/arylesterase (AREase) activity of PON1, its PON1-Q192R and PON1-L55M polymorphisms, and BuChE activity with the nutritional status and lipid profiles in a group of children from rural communities in Mexico.
   Methods: A group of 97 boys and girls from a rural community in Mexico were assessed for body mass index, the enzymatic activities of BuChE, PONase, and AREase were measured in serum, and their lipid profiles were determined. Genetic polymorphisms of PON1-L55M and PON1-Q192R were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).
   Results: The children were classified into four groups: thinness, normal weight, overweight, and obese. Of the children studied, 34.4% were overweight and obese. The mean age of the participants was 9.5 years (standard deviation = 1.8). The L allele of the PON1-L55M genotype was the most frequent (83.3%), and the R allele of the PON1-Q192R genotype was the most frequent (61.8%). Overweight and obese children had higher values of BuChE, total cholesterol, triglycerides (TG), and lower high-density lipoprotein (HDL-C) values than children with thinness or normal weight (P = 0.028, P = 0.019, P = 0.004, P = 0.069 and P = 0.021, respectively). The levels of AREase and PONase and the prevalence of PON1-L55M and PON1-Q192R genotypes were similar between groups (P = 0.484 and P = 0.380, respectively).
   Conclusions: This study establishes a positive association of BuChE activity with nutritional status and serum TG.
C1 [Ramirez-Jimenez, Rocio] Inst Politecn Nacl, CIIDIR, Unidad Michoacan, Mexico City, Michoacan, Mexico.
   [Fernanda Martinez-Salazar, Maria] Univ Autonoma Estado Morelos, Fac Ciencias Deporte, Cuernavaca, Morelos, Mexico.
   [Almenares-Lopez, Damianys] Univ Popular Chontalpa, Div Ciencias Agr & Ingn, Cardenas, Tabasco, Mexico.
   [Yanez-Estrada, Leticia] Univ Autonoma San Luis Potosi, Fac Med, Lab Genero Salud & Ambiente, San Luis Potosi, Mexico.
   [Monroy-Noyola, Antonio] Univ Autonoma Estado Morelos, Fac Farm, Lab Neuroprotecc, Ave Univ 1001, Cuernavaca 62209, Morelos, Mexico.
C3 Instituto Politecnico Nacional - Mexico; Universidad Autonoma del Estado
   de Morelos; Universidad Autonoma de San Luis Potosi; Universidad
   Autonoma del Estado de Morelos
RP Monroy-Noyola, A (corresponding author), Univ Autonoma Estado Morelos, Fac Farm, Lab Neuroprotecc, Ave Univ 1001, Cuernavaca 62209, Morelos, Mexico.
EM amonroy@uaem.mx
RI Monroy, Antonio/ITU-0998-2023
OI ALMENARES LOPEZ, DAMIANYS/0000-0003-0247-4624; Monroy Noyola,
   Antonio/0000-0001-6743-6237
FU Instituto Politecnico Nacional; National Council of Science and
   Technology (CONACYT); PROMEP/SEP Red de Cuerpos Academicos: "Diagnostico
   Clinico de Enfermedades metabolicas''
FX This study was performed with funding and support from the Instituto
   Politecnico Nacional, the National Council of Science and Technology
   (CONACYT), and the PROMEP/SEP Red de Cuerpos Academicos: "Diagnostico
   Clinico de Enfermedades metabolicas.'' The authors thank Biologist
   Eugenio Lopez Bustos (Instituto de Biotecnologia-UNAM) for
   oligonucleotide synthesis.
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NR 38
TC 4
Z9 4
U1 0
U2 23
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-4196
EI 1557-8518
J9 METAB SYNDR RELAT D
JI Metab. Syndr. Relat. Disord.
PD MAR
PY 2018
VL 16
IS 2
BP 90
EP 96
DI 10.1089/met.2017.0138
EA FEB 2018
PG 7
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA FY1GU
UT WOS:000424086700001
PM 29393817
DA 2025-06-11
ER

PT J
AU Richter, CK
   Skulas-Ray, AC
   Gaugler, TL
   Lambert, JD
   Proctor, DN
   Kris-Etherton, PM
AF Richter, Chesney K.
   Skulas-Ray, Ann C.
   Gaugler, Trent L.
   Lambert, Joshua D.
   Proctor, David N.
   Kris-Etherton, Penny M.
TI Incorporating freeze-dried strawberry powder into a high-fat meal does
   not alter postprandial vascular function or blood markers of
   cardiovascular disease risk: a randomized controlled trial
SO AMERICAN JOURNAL OF CLINICAL NUTRITION
LA English
DT Article
DE augmentation index; cardiovascular disease; hyperlipidemia;
   phytochemicals; postprandial dysmetabolism
ID CENTRAL ARTERY STIFFNESS; ENDOTHELIAL FUNCTION; LIPID-PEROXIDATION;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; OXIDATIVE STRESS; AORTIC
   PRESSURE; HEALTHY; GLUCOSE; LIPEMIA
AB Background: Postprandial dysmetabolism an exaggerated spike in triglycerides, glucose, and insulin increases cardiovascular disease risk by inducing oxidative stress, inflammation, and endothelial dysfunction. Polyphenol-rich foods may blunt these effects when they are incorporated into a high-fat, calorie-dense meal. Strawberries are a rich source of polyphenols, but there is little research on their postprandial effects.
   Objective: This study was designed to investigate the effect of adding 40 g freeze-dried strawberry powder (similar to 1 lb. or 0.45 kg fresh strawberries) to a high-fat (50 g total fat) meal on postprandial vascular function, as well as triglyceride, glucose, and insulin responses.
   Design: Healthy, overweight or obese [mean SEM body mass index (in kg/m(2)): 31 +/- 0.5] adults (mean SEM age: 28 +/- 2 y; 17 men and 13 women) consumed a control meal and a strawberry meal in a randomized crossover design. Testing sessions were separated by wk for men and similar to 1 mo for women to control for hormonal variations. Blood samples were obtained before the meal and 0.5, 1, 2, and 4 h after the meal. Central blood pressure and arterial stiffness indexes were measured at baseline and 2 and 4 h postmeal with the use of pulse waveform analysis.
   Results: There were no significant differences between the strawberry and control meals for any outcomes. Consumption of either meal significantly decreased the augmentation index at 2 and 4 h (P < 0.002) and significantly increased triglycerides, insulin, and glucose at all time points (P < 0.001) relative to baseline.
   Conclusions: The strawberry intervention did not alter vascular function or attenuate postprandial metabolic derangements in triglycerides, glucose, or insulin relative to the control meal Additional research is needed to clarify whether strawberries or other polyphenol-rich interventions improve postprandial responses, and future studies should take into account the acute meal-induced improvements in measures of vascular function.
C1 [Richter, Chesney K.; Skulas-Ray, Ann C.; Kris-Etherton, Penny M.] Penn State Univ, Dept Nutr Sci, University Pk, PA 16802 USA.
   [Lambert, Joshua D.] Penn State Univ, Dept Food Sci, University Pk, PA 16802 USA.
   [Proctor, David N.] Penn State Univ, Dept Kinesiol, University Pk, PA 16802 USA.
   [Gaugler, Trent L.] Lafayette Coll, Dept Math, Easton, PA 18042 USA.
   [Richter, Chesney K.; Skulas-Ray, Ann C.] Univ Arizona, Dept Nutr Sci, 1177 East 4th St,Shantz Bldg,Room 309, Tucson, AZ 85721 USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE);
   Pennsylvania State University; Pennsylvania State University -
   University Park; Penn State Behrend; Pennsylvania Commonwealth System of
   Higher Education (PCSHE); Pennsylvania State University; Pennsylvania
   State University - University Park; Penn State Behrend; Pennsylvania
   Commonwealth System of Higher Education (PCSHE); Pennsylvania State
   University; Pennsylvania State University - University Park; Penn State
   Behrend; Lafayette College; University of Arizona
RP Kris-Etherton, PM (corresponding author), Penn State Univ, Dept Nutr Sci, University Pk, PA 16802 USA.
EM pmk3@psu.edu
RI Lambert, Joshua/M-1788-2014; Gaugler, Trent/KEI-4542-2024
OI Richter, Chesney/0000-0002-5658-6173; Skulas-Ray,
   Ann/0000-0003-2914-9055; Kris-Etherton, Penny/0000-0001-6012-4900;
   Gaugler, Trent/0000-0002-8006-9184
FU California Strawberry Commission; Penn State Clinical and Translational
   Research Institute; Pennsylvania State University Clinical and
   Translational Science Award; NIFI/National Center for Advancing
   Translational Sciences [UL1 TR000127]
FX Supported by the California Strawberry Commission, which provided
   financial support for the study as well as the freeze-dried strawberry
   and control powders. Also supported by the Penn State Clinical and
   Translational Research Institute, Pennsylvania State University Clinical
   and Translational Science Award, and NIFI/National Center for Advancing
   Translational Sciences grant no. UL1 TR000127.
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NR 65
TC 27
Z9 32
U1 2
U2 22
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0002-9165
EI 1938-3207
J9 AM J CLIN NUTR
JI Am. J. Clin. Nutr.
PD FEB
PY 2017
VL 105
IS 2
BP 313
EP 322
DI 10.3945/ajcn.116.141804
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA EJ6SK
UT WOS:000393348900006
PM 28003205
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Khadir, A
   Tiss, A
   Abubaker, J
   Abu-Farha, M
   Al-Khairi, I
   Cherian, P
   John, J
   Kavalakatt, S
   Warsame, S
   Al-Madhoun, A
   Al-Ghimlas, F
   Elkum, N
   Behbehani, K
   Dermime, S
   Dehbi, M
AF Khadir, Abdelkrim
   Tiss, Ali
   Abubaker, Jehad
   Abu-Farha, Mohamed
   Al-Khairi, Irina
   Cherian, Preethi
   John, Jeena
   Kavalakatt, Sina
   Warsame, Samia
   Al-Madhoun, Ashraf
   Al-Ghimlas, Fahad
   Elkum, Naser
   Behbehani, Kazem
   Dermime, Said
   Dehbi, Mohammed
TI MAP kinase phosphatase DUSP1 is overexpressed in obese humans and
   modulated by physical exercise
SO AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
LA English
DT Article
DE dual-specificity phosphatase 1; mitogen-activated protein kinase
   phosphatase 1; obesity; physical exercise; peroxisome
   proliferator-activated receptor-gamma coactivator-1 alpha
ID ACTIVATED PROTEIN-KINASE; SUBCUTANEOUS ADIPOSE-TISSUE; JUN NH2-TERMINAL
   KINASE; INSULIN-RESISTANCE; SKELETAL-MUSCLE; GENE-EXPRESSION; P38 MAPK;
   METABOLIC SYNDROME; MONONUCLEAR-CELLS; RETICULUM STRESS
AB Chronic low-grade inflammation and dysregulation of the stress defense system are cardinal features of obesity, a major risk factor for the development of insulin resistance and diabetes. Dual-specificity protein phosphatase 1 (DUSP1), known also as MAP kinase phosphatase 1 (MKP1), is implicated in metabolism and energy expenditure. Mice lacking DUSP1 are resistant to high-fat diet-induced obesity. However, the expression of DUSP1 has not been investigated in human obesity. In the current study, we compared the expression pattern of DUSP1 between lean and obese nondiabetic human subjects using subcutaneous adipose tissue (SAT) and peripheral blood mononuclear cells (PBMCs). The levels of DUSP1 mRNA and protein were significantly increased in obese subjects with concomitant decrease in the phosphorylation of p38 MAPK (p-p38 MAPK) and PGC-1 alpha and an increase in the levels of phospho-JNK (p-JNK) and phospho-ERK (p-ERK). Moreover, obese subjects had higher levels of circulating DUSP1 protein that correlated positively with various obesity indicators, triglycerides, glucagon, insulin, leptin, and PAI-1 (P < 0.05) but negatively with VO2max and high-density lipoprotein (P < 0.05). The observation that DUSP1 was overexpressed in obese subjects prompted us to investigate whether physical exercise could reduce its expression. In this study, we report for the first time that physical exercise significantly attenuated the expression of DUSP1 in both the SAT and PBMCs, with a parallel increase in the expression of PGC-1 alpha and a reduction in the levels of p-JNK and p-ERK along with attenuated inflammatory response. Collectively, our data suggest that DUSP1 upregulation is strongly linked to adiposity and that physical exercise modulates its expression. This gives further evidence that exercise might be useful as a strategy for managing obesity and preventing its associated complications.
C1 [Khadir, Abdelkrim; Tiss, Ali; Abubaker, Jehad; Abu-Farha, Mohamed; Al-Khairi, Irina; Cherian, Preethi; John, Jeena; Kavalakatt, Sina; Warsame, Samia; Al-Madhoun, Ashraf; Behbehani, Kazem] Dasman Diabet Inst, Dept Biomed Res, Kuwait, Kuwait.
   [Al-Ghimlas, Fahad; Behbehani, Kazem] Dasman Diabet Inst, Fitness & Rehabil Ctr, Kuwait, Kuwait.
   [Elkum, Naser; Behbehani, Kazem] Dasman Diabet Inst, Dept Biostatist & Epidemiol, Kuwait, Kuwait.
   [Dermime, Said] King Fahad Specialist Hosp, Dammam, Saudi Arabia.
   [Dehbi, Mohammed] Educ City, Qatar Fdn, Diabet Res Ctr, Qatar Biomed Res Inst, Doha, Qatar.
C3 Dasman Diabetes Institute (DDI); Dasman Diabetes Institute (DDI); Dasman
   Diabetes Institute (DDI); Qatar Foundation (QF); Hamad Bin Khalifa
   University-Qatar; Qatar Biomedical Research Institute (QBRI)
RP Dehbi, M (corresponding author), Educ City, Qatar Fdn, Diabet Res Ctr, Qatar Biomed Res Inst, POB 5825, Doha, Qatar.
EM mdehbi@qf.org.qa
RI Al Madhoun, Ashraf/I-3043-2012; Abu-Farha, Mohamed/KHW-8579-2024;
   Abubaker, Jehad/KHV-9373-2024; Tiss, Ali/L-6656-2019; Elkum,
   Naser/AAU-5555-2020; Dermime, Said/P-2448-2019
OI Abu-Farha, Mohamed/0000-0001-8357-1252; Al Madhoun,
   Ashraf/0000-0001-8593-3878; kavalakatt, sina/0000-0003-3795-1881; Tiss,
   Ali/0000-0002-3024-5370; Cherian, Preethi/0000-0002-2132-3533; Elkum,
   Naser/0000-0002-0457-0444
FU Kuwait Foundation for the Advancement of Sciences [RA-2010-003]
FX This work was supported by the Kuwait Foundation for the Advancement of
   Sciences under project no. RA-2010-003.
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NR 72
TC 39
Z9 42
U1 0
U2 18
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0193-1849
EI 1522-1555
J9 AM J PHYSIOL-ENDOC M
JI Am. J. Physiol.-Endocrinol. Metab.
PD JAN 1
PY 2015
VL 308
IS 1
BP E71
EP E83
DI 10.1152/ajpendo.00577.2013
PG 13
WC Endocrinology & Metabolism; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Physiology
GA AW7ZJ
UT WOS:000346480000007
PM 25370852
DA 2025-06-11
ER

PT J
AU Anderson, LN
   Briollais, L
   Atkinson, HC
   Marsh, JA
   Xu, JX
   Connor, KL
   Matthews, SG
   Pennell, CE
   Lye, SJ
AF Anderson, Laura N.
   Briollais, Laurent
   Atkinson, Helen C.
   Marsh, Julie A.
   Xu, Jingxiong
   Connor, Kristin L.
   Matthews, Stephen G.
   Pennell, Craig E.
   Lye, Stephen J.
TI Investigation of Genetic Variants, Birthweight and Hypothalamic-
   Pituitary- Adrenal Axis Function Suggests a Genetic Variant in the
   SERPINA6 Gene Is Associated with Corticosteroid Binding Globulin in the
   Western Australia Pregnancy Cohort ( Raine) Study
SO PLOS ONE
LA English
DT Article
ID SINGLE-NUCLEOTIDE POLYMORPHISMS; PLASMA-CORTISOL CONCENTRATIONS;
   SALIVARY CORTISOL; HPA AXIS; METABOLIC SYNDROME; STRESS RESPONSES;
   GENOME-WIDE; BODY-SIZE; CHILDREN; OBESITY
AB Background: The hypothalamic-pituitary-adrenal (HPA) axis regulates stress responses and HPA dysfunction has been associated with several chronic diseases. Low birthweight may be associated with HPA dysfunction in later life, yet human studies are inconclusive. The primary study aim was to identify genetic variants associated with HPA axis function. A secondary aim was to evaluate if these variants modify the association between birthweight and HPA axis function in adolescents.
   Methods: Morning fasted blood samples were collected from children of the Western Australia Pregnancy Cohort (Raine) at age 17 ( n =1077). Basal HPA axis function was assessed by total cortisol, corticosteroid binding globulin (CBG), and adrenocorticotropic hormone ( ACTH). The associations between 124 tag single nucleotide polymorphisms ( SNPs) within 16 HPA pathway candidate genes and each hormone were evaluated using multivariate linear regression and penalized linear regression analysis using the HyperLasso method.
   Results: The penalized regression analysis revealed one candidate gene SNP, rs11621961 in the CBG encoding gene ( SERPINA6), significantly associated with total cortisol and CBG. No other candidate gene SNPs were significant after applying the penalty or adjusting for multiple comparisons; however, several SNPs approached significance. For example, rs907621 (p=0.002) and rs3846326 (p=0.003) in the mineralocorticoid receptor gene ( NR3C2) were associated with ACTH and SERPINA6 SNPs rs941601 (p=0.004) and rs11622665 (p=0.008), were associated with CBG. To further investigate our findings for SERPINA6, rare and common SNPs in the gene were imputed from the 1,000 genomes data and 8 SNPs across the gene were significantly associated with CBG levels after adjustment for multiple comparisons. Birthweight was not associated with any HPA outcome, and none of the gene- birthweight interactions were significant after adjustment for multiple comparisons.
   Conclusions: Our study suggests that genetic variation in the SERPINA6 gene may be associated with altered CBG levels during
C1 [Anderson, Laura N.; Briollais, Laurent; Xu, Jingxiong; Connor, Kristin L.; Lye, Stephen J.] Mt Sinai Hosp, Lunenfeld Tanenbaum Res Inst, Toronto, ON M5G 1X5, Canada.
   [Atkinson, Helen C.; Marsh, Julie A.; Pennell, Craig E.] Univ Western Australia, Sch Womens & Infants Hlth, Crawley, WA, Australia.
   [Matthews, Stephen G.] Univ Toronto, Dept Physiol, Toronto, ON, Canada.
   [Lye, Stephen J.] Univ Toronto, Fraser Mustard Inst Human Dev, Toronto, ON, Canada.
   [Lye, Stephen J.] Univ Toronto, Dept Obstet & Gynaecol, Toronto, ON, Canada.
C3 University of Toronto; Sinai Health System Toronto; Lunenfeld Tanenbaum
   Research Institute; University of Western Australia; University of
   Toronto; University of Toronto; University of Toronto
RP Anderson, LN (corresponding author), Mt Sinai Hosp, Lunenfeld Tanenbaum Res Inst, Toronto, ON M5G 1X5, Canada.
EM Lye@lunenfeld.ca
RI Briollais, Laurent/A-2941-2013; Anderson, Laura/K-4707-2019; Pennell,
   Craig/ABD-6902-2020; Matthews, Stephen/N-7555-2018; Lye,
   Stephen/E-7269-2013; Pennell, Craig/C-5190-2011; Atkinson,
   Helen/B-9246-2015
OI Matthews, Stephen/0000-0002-9654-9940; Anderson, Laura
   N./0000-0002-6106-5073; Pennell, Craig/0000-0002-0937-6165; Atkinson,
   Helen/0000-0002-2172-3780; Marsh, Julie/0000-0001-8984-6907
FU National Health and Medical Research Council of Australia [353514,
   572613, 403981]; Canadian Institutes of Health Research [MOP82893];
   University of Western Australia (UWA); Raine Medical Research
   Foundation; Telethon Institute for Child Health Research; UWA Faculty of
   Medicine; Dentistry and Health Sciences; Women and Infants Research
   Foundation; Curtin University
FX This work was supported by funding for the 17-year follow-up and
   genotyping provided by the National Health and Medical Research Council
   of Australia (353514, 572613, 403981) and the Canadian Institutes of
   Health Research (MOP82893). Core funding for the Raine Study is provided
   by the University of Western Australia (UWA), Raine Medical Research
   Foundation, the Telethon Institute for Child Health Research, UWA
   Faculty of Medicine, Dentistry and Health Sciences, the Women and
   Infants Research Foundation and Curtin University. LNA and KLC are
   funded by Canadian Institutes of Health Research postdoctoral fellowship
   awards. The funders had no role in study design, data collection and
   analysis, decision to publish, or preparation of the manuscript.
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NR 43
TC 10
Z9 13
U1 0
U2 0
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD APR 1
PY 2014
VL 9
IS 4
AR e92957
DI 10.1371/journal.pone.0092957
PG 8
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA AE6KM
UT WOS:000334101100037
PM 24691024
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Himmetoglu, S
   Teksoz, S
   Zengin, K
   Yesim, T
   Taskin, M
   Dincer, Y
AF Himmetoglu, S.
   Teksoz, S.
   Zengin, K.
   Yesim, T.
   Taskin, M.
   Dincer, Y.
TI Serum Levels of Fetuin A and 8-hydroxydeoxyguanosine in Morbidly Obese
   Subjects
SO EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
LA English
DT Article
DE insulin resistance; oxidative stress; oxidative DNA damage; fetuin A;
   8-hydroxydeoxyguanosine
ID OXIDATIVE DNA-DAMAGE; FATTY LIVER-DISEASE; INSULIN-RESISTANCE;
   DIABETES-MELLITUS; METABOLIC SYNDROME; WEIGHT-LOSS; BARIATRIC SURGERY;
   PROTEIN CARBONYL; CELL INJURY; STRESS
AB Insulin resistance is one of the feature of obesity. Fetuin A is inhibitor of insulin receptor which belongs the family of receptor tyrosine kinase. It has been observed that fetuin-null mice are resistant to diet-induced obesity and they exhibit increased insulin sensitivity. Increased production of reactive oxygen species is suggested to be associated with insulin resistance. Attacks of reactive oxygen species to DNA results in base oxidation. Among the oxidized bases, 8-hydroxydeoxyguanosine is predominant lesion with pro-mutagenic potential. In the present study; measurement of serum levels of fetuin A and 8-hydroxydeoxyguanosine in obese subjects (n = 46) and healthy controls (n = 22), and examination of the relations between these parameters and insulin resistance have been purposed. Blood samples were taken form morbidly obese subjects after a 12 h fasting. Serum levels of fetuin A and 8-hydroxydeoxyguanosine were measured by ELISA. Statistical analysis was performed by Mann Whitney U test and correlations were examined by Spearman correlation coefficient. Serum levels of total cholesterol, HDL, LDL, VLDL, triglycerides, free T 3, free T 4, fasting glucose, c-peptide and %HbA1c in the obese group were found to be different from those in the control group. Serum level of fetuin A was found to be higher, 8-hydroxydeoxyguanosine level was found to be lower in the morbid obese group than those in the control group. Fetuin A was found to be positively correlated with HOMA-IR (r:0,40, P < 0.05) and negatively correlated with 8-hydroxydeoxyguanosine (r:-0,52, P < 0.01). No significant association was determined between body mass index and measured parameters. In conclusion, serum level of fetuin A is high in morbidly obese subjects and is negatively associated with 8-hydroxydeoxyguanosine level in peripheral circulation. Fetuin A may be a promising link between insulin resistance and obesity as well its comorbidities.
C1 [Himmetoglu, S.] Ctr Labs, Istanbul, Turkey.
   [Teksoz, S.; Zengin, K.; Taskin, M.] Istanbul Univ, Cerrahpasa Med Fac, Dept Gen Surg, Istanbul, Turkey.
   [Yesim, T.] Haseki Educ & Res Hosp, Istanbul, Turkey.
   [Dincer, Y.] Istanbul Univ, Cerrahpasa Med Fac, Dept Biochem, Istanbul, Turkey.
C3 Istanbul University; Istanbul University - Cerrahpasa; Istanbul Haseki
   Training & Research Hospital; Istanbul University - Cerrahpasa; Istanbul
   University
RP Dincer, Y (corresponding author), Dere Sok,Umut Ap 11-44 Sahrayi, Cedid, Erenkoy Istanbu, Turkey.
EM yldz.dincer@gmail.com
RI yeşim, tijen/AFK-2750-2022; TASKIN, Mustafa/KIJ-0843-2024; TEKSOZ,
   Serkan/AAC-3959-2019; Dincer, Yildiz/C-9529-2019
OI TEKSOZ, Serkan/0000-0002-6733-5644; Dincer, Yildiz/0000-0002-8393-7901
FU Istanbul University [BYP-4413]
FX This work was supported by the Research Fund of Istanbul University
   (Project no: BYP-4413).
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NR 29
TC 14
Z9 16
U1 0
U2 9
PU JOHANN AMBROSIUS BARTH VERLAG MEDIZINVERLAGE HEIDELBERG GMBH
PI STUTTGART
PA RUEDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0947-7349
EI 1439-3646
J9 EXP CLIN ENDOCR DIAB
JI Exp. Clin. Endocrinol. Diabet.
PD AUG
PY 2013
VL 121
IS 8
BP 505
EP 508
DI 10.1055/s-0033-1345162
PG 4
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 222KY
UT WOS:000324731000011
PM 23765754
DA 2025-06-11
ER

PT J
AU Padilla, J
   Jenkins, NT
   Vieira-Potter, VJ
   Laughlin, MH
AF Padilla, Jaume
   Jenkins, Nathan T.
   Vieira-Potter, Victoria J.
   Laughlin, M. Harold
TI Divergent phenotype of rat thoracic and abdominal perivascular adipose
   tissues
SO AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE
   PHYSIOLOGY
LA English
DT Article
DE brown fat; obesity; perivascular fat; vascular function; white fat
ID WALL SHEAR-STRESS; IN-VIVO QUANTIFICATION; LOWER-LIMB EXERCISE;
   ENDOTHELIAL DYSFUNCTION; OXIDATIVE STRESS; CAROTID BIFURCATION;
   METABOLIC SYNDROME; LEPTIN; ATHEROSCLEROSIS; OBESITY
AB Padilla J, Jenkins NT, Vieira-Potter VJ, Laughlin MH. Divergent phenotype of rat thoracic and abdominal perivascular adipose tissues. Am J Physiol Regul Integr Comp Physiol 304: R543-R552, 2013. First published February 6, 2013; doi:10.1152/ajpregu.00567.2012.-Perivascular adipose tissue (PVAT) is implicated as a source of proatherogenic cytokines. Phenotypic differences in local PVAT depots may contribute to differences in disease susceptibility among arteries and even regions within an artery. It has been proposed that PVAT around the abdominal and thoracic aorta shares characteristics of white and brown adipose tissue (BAT), respectively; however, a detailed comparison of the phenotype of these PVAT depots has not been performed. Using young and older adult rats, we compared the phenotype of PVATs surrounding the abdominal and thoracic aorta to each other and also to epididymal white and subscapular BAT. Compared with young rats, older rats exhibited greater percent body fat (34.5 +/- 3.1 vs. 10.4 +/- 0.9%), total cholesterol (112.2 +/- 7.5 vs. 58.7 +/- 6.3 mg/dl), HOMA-insulin resistance (1.7 +/- 0.1 vs. 0.9 +/- 0.1 a.u.), as well as reduced ACh-induced relaxation of the aorta (maximal relaxation: 54 +/- 10 vs. 77 +/- 6%) (all P < 0.05). Expression of inflammatory genes and markers of immune cell infiltration were greater in abdominal PVAT than in thoracic PVAT, and overall, abdominal and thoracic PVATs resembled the phenotype of white adipose tissue (WAT) and BAT, respectively. Histology and electron microscopy indicated structural similarity between visceral WAT and abdominal PVAT and between BAT and thoracic PVAT. Our data provide evidence that abdominal PVAT is more inflamed than thoracic PVAT, a difference that was by and large independent of sedentary aging. Phenotypic differences in PVAT between regions of the aorta may be relevant in light of the evidence in large animals and humans that the abdominal aorta is more vulnerable to atherosclerosis than the thoracic aorta.
C1 [Padilla, Jaume; Jenkins, Nathan T.; Vieira-Potter, Victoria J.; Laughlin, M. Harold] Univ Missouri, Columbia, MO 65211 USA.
   [Laughlin, M. Harold] Univ Missouri, Dalton Cardiovasc Res Ctr, Columbia, MO 65211 USA.
C3 University of Missouri System; University of Missouri Columbia;
   University of Missouri System; University of Missouri Columbia
RP Padilla, J (corresponding author), Univ Missouri, Dept Biomed Sci, 1600 E Rollins Rd, Columbia, MO 65211 USA.
EM padillaja@missouri.edu
OI Vieira-Potter, Victoria/0000-0001-7563-0806
FU National Institutes of Health (NIH) [RO1-HL-036088, T32-AR048523];
   American Heart Association [11POST5080002]; University of Missouri
   Institute for Clinical and Translational Sciences
FX This work was supported by National Institutes of Health (NIH) Grant
   RO1-HL-036088 (to M. H. Lauglin), American Heart Association Grant
   11POST5080002 (to J. Padilla), NIH T32-AR048523 (to N. T. Jenkins), and
   University of Missouri Institute for Clinical and Translational Sciences
   (to J. Padilla).
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NR 52
TC 144
Z9 151
U1 1
U2 14
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0363-6119
EI 1522-1490
J9 AM J PHYSIOL-REG I
JI Am. J. Physiol.-Regul. Integr. Comp. Physiol.
PD APR
PY 2013
VL 304
IS 7
BP R543
EP R552
DI 10.1152/ajpregu.00567.2012
PG 10
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA 118CZ
UT WOS:000317001600007
PM 23389108
OA Green Published
DA 2025-06-11
ER

PT J
AU Hua, TC
   Zheng, SQ
   Ding, JW
   Geng, ZY
   Zhang, W
   Qi, TY
   Li, YF
   Wang, XX
AF Hua, Tianchi
   Zheng, Shengqi
   Ding, Jiawen
   Geng, Zhaoyong
   Zhang, Wei
   Qi, Tingyue
   Li, Yifan
   Wang, Xiaoxiang
TI Cross-sectional study on the association between serum uric acid levels
   and the risk of benign prostatic hyperplasia
SO BMJ OPEN
LA English
DT Article
DE Retrospective Studies; Prostate disease; General endocrinology;
   EPIDEMIOLOGIC STUDIES; Public health
ID URINARY-TRACT SYMPTOMS; OXIDATIVE STRESS; METABOLIC SYNDROME;
   MANAGEMENT; CANCER
AB Objective Serum uric acid (SUA), a non-protein antioxidant, exerts anti-inflammatory and antioxidative stress effects. This study aimed to investigate the association between SUA levels and the risk of benign prostatic hyperplasia (BPH). Methods This cross-sectional study included 48 653 adult men who underwent health checkups at the Health Examination Center of the Affiliated Hospital of Yangzhou University in 2022. Data on demographics, clinical history and laboratory parameters were collected. Multivariable logistic regression models were used to analyse the relationship between SUA levels and BPH risk, with further exploration in different subgroups. Results Logistic regression analysis revealed a significantly decreased risk of BPH among participants in the highest SUA quartile (Q4) compared with those in the lowest quartile (Q1) (fully adjusted OR=0.83, 95% CI: 0.78 to 0.90, p<0.0001). Subgroup analyses demonstrated that this inverse association was more pronounced in subgroups of age>60 years (Q4: OR=0.77, 95% CI: 0.68 to 0.87, p<0.0001), non-obesity (Q4: OR=0.81, 95% CI: 0.75 to 0.87, p<0.0001), without non-alcoholic fatty liver disease (NAFLD) (Q4: OR=0.81, 95% CI: 0.73 to 0.89, p<0.0001), hypertension (Q4: OR=0.81, 95% CI: 0.74 to 0.89, p<0.0001) and without diabetes (Q4: OR=0.84, 95% CI: 0.78 to 0.90, p<0.0001). Curve fitting revealed that higher SUA levels were associated with a lower risk of BPH even in the presence of increased BPH risk factors such as diabetes and hypertension. Conclusions This study demonstrates a significant inverse association between SUA levels and BPH risk, particularly in subgroups of older age, non-obesity, absence of NAFLD, hypertension and absence of diabetes. This suggests a potential protective role of SUA in BPH development, highlighting the potential value of maintaining SUA levels within a reasonable range for BPH prevention.
C1 [Hua, Tianchi; Zheng, Shengqi; Ding, Jiawen; Geng, Zhaoyong; Zhang, Wei; Qi, Tingyue; Li, Yifan; Wang, Xiaoxiang] Yangzhou Univ, Affiliated Hosp, Yangzhou, Jiangsu, Peoples R China.
C3 Yangzhou University
RP Li, YF; Wang, XX (corresponding author), Yangzhou Univ, Affiliated Hosp, Yangzhou, Jiangsu, Peoples R China.
EM 1421351470@qq.com; shengqi_zheng@163.com; 18852722496@163.com;
   yzayong@126.com; 352828654@qq.com; tyqi@yzu.edu.cn; 092107@yzu.edu.cn;
   18936489811@163.com
RI ding, jiawen/LIA-9625-2024
OI Hua, Tianchi/0000-0001-7196-0728
FU Youth Fund Project; Health Examination Center of the Affiliated Hospital
   of Yangzhou University
FX We express our sincere gratitude to Director Xiaoping Yu from the Health
   Examination Center of the Affiliated Hospital of Yangzhou University for
   his support of this research.
CR Abbasi Sarwat, 2019, J Ayub Med Coll Abbottabad, V31, P64
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NR 34
TC 0
Z9 0
U1 0
U2 0
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2044-6055
J9 BMJ OPEN
JI BMJ Open
PD MAR 18
PY 2025
VL 15
IS 3
AR e092844
DI 10.1136/bmjopen-2024-092844
PG 10
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 0KP4W
UT WOS:001449605100001
PM 40107683
OA gold
DA 2025-06-11
ER

PT J
AU Ekici, M
   Demir, E
   Aydin, C
AF Ekici, M.
   Demir, E.
   Aydin, C.
TI A bibliometric perspective with research trends and global productivity
   on the modernization of andrology from the founder of modern clinical
   andrology Edward Martin to the present
SO EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
LA English
DT Article
ID SPERM DNA FRAGMENTATION; HUMAN-SPERMATOZOA; SUPEROXIDE-DISMUTASE;
   LIPID-PEROXIDATION; INTEGRITY; EXPOSURE; MOTILITY; MORPHOLOGY; MEMBRANE;
   VALUES
AB - OBJECTIVE: The number of studies in the field of andrology is increasing day by day, but a bibliometric study covering the entire literature on andrology has not yet been conduct-ed. This bibliometric study aims to shed light on the question of where we came from and where we are going in andrology from past to present. It also aimed to summarize the intellectual structure of andrology to reveal global productivity and identify and map the latest trends of scien-tific articles published in the field of andrology. MATERIALS AND METHODS: 16,659 articles published between 1980 and 2022 were ex-tracted from the Web of Science and analyzed using various statistical methods. Bibliomet-ric network visualization maps revealed trending topics, global productivity, the most influ-ential studies, and international collaborations. Spearman's correlation analysis was used for determining correlations. RESULTS: The top three productive countries were United States of America (3,452; 20.7%), China (2,300; 13.8%), and Germany (1,069; 6.4%). The top two most productive authors were Agarwal A. (n=130) and Nieschlag E. (n=130). The most productive institution was the Egyptian Knowledge Bank (n=422). From past to present, the most studied subjects were testis, male infertility, spermatozoa, testosterone, infertility, erectile dysfunction, spermatogenesis, sperm, prostate cancer (PCA)/neoplasms, oxidative stress, fertility/fertilization, semen, rat(s), apoptosis, azoospermia, sperm motility, human and varicocele. CONCLUSIONS: The trend topics that have been researched more in recent years include erectile dysfunction, oxidative stress, prostate cancer, sperm quality, sperm parameters, infer-tility, premature ejaculation, diabetes mellitus, obesity, prognosis, sperm DNA fragmentation/ damage, antioxidant, asthenozoospermia, var-icocelectomy, COVID-19, inflammation, prostatectomy, metabolic syndrome, hypogonadism, benign prostatic hyperplasia, lower urinary tract symptoms, meta-analysis, sexual dysfunction, peyronie's disease, and proliferation. We iden-tified the research leadership of China, Japan, Turkey and India, in addition to Western coun-tries, such as the USA and European countries.
C1 [Ekici, M.; Aydin, C.] Hitit Univ, Fac Med, Dept Urol, Corum, Turkiye.
   [Ekici, M.; Demir, E.] Hitit Univ, Fac Med, Dept Biostat, Corum, Turkiye.
C3 Hitit University; Hitit University
RP Ekici, M (corresponding author), Hitit Univ, Fac Med, Dept Urol, Corum, Turkiye.; Ekici, M (corresponding author), Hitit Univ, Fac Med, Dept Biostat, Corum, Turkiye.
EM musaekici40@gmail.com
RI Demir, Emre/AAA-8193-2020
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NR 47
TC 10
Z9 10
U1 4
U2 9
PU VERDUCI PUBLISHER
PI ROME
PA VIA GREGORIO VII, ROME, 186-00165, ITALY
SN 1128-3602
J9 EUR REV MED PHARMACO
JI Eur. Rev. Med. Pharmacol. Sci.
PD DEC
PY 2023
VL 27
IS 24
BP 11947
EP 11960
PG 14
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA HS3E9
UT WOS:001161448100009
PM 38164858
DA 2025-06-11
ER

PT J
AU Guzmán, MA
   Olguín, MA
AF Andrews Guzman, Monica
   Arredondo Olguin, Miguel
TI Association between ferritin, high sensitivity c-reactive protein
   (hsCRP) and relative abundance of Hepcidin mRNA with the risk of type 2
   diabetes in obese subjects
SO NUTRICION HOSPITALARIA
LA English
DT Article
DE Inflammatory cytokines; Iron; Hepcidin; Ferritin; Obesity
ID OXIDATIVE STRESS; INSULIN-RESISTANCE; ANTIOXIDANT STATUS; METABOLIC
   SYNDROME; IRON STORES; INFLAMMATION; INTERLEUKIN-6; EXPRESSION; SOCS-3
AB Obesity and Type 2 diabetes mellitus share a strong pro-inflammatory profile. It has been observed that iron is a risk factor in the development of type 2 diabetes. The aim of this study was to evaluate the relationship between iron nutritional status and inflammation with the risk of type 2 diabetes development in obese subjects. We studied 30 obese men with type 2 diabetes (OBDM); 30 obese subjects without diabetes (OB) and 30 healthy subjects (Cu). We isolated peripheral mononuclear cells (PMCs) and challenged them with high Fe concentrations. Total mRNA was isolated and relative abundance of TNF-alpha, IL-6 and hepcidin were determined by qPCR. Iron status, biochemical, inflammatory and oxidative stress parameters were also characterized. OBDM and OB patients showed increased hsCRP levels compared to the Cn group. OBDM subjects showed higher levels of ferritin than the Cu group. TNF-alpha and IL-6 mRNA relative abundances were increased in OBDM PMCs treated with high/Fe. Hepcidin mRNA was increased with basal and high iron concentration. We found that the highest quartile of ferritin was associated with an increased risk of type 2 diabetes when it was adjusted to BMI and HOMA-IR; this association was independent of the inflammatory status. The highest level of hepcidin gene expression also showed a trend of increased risk of diabetes, however it was not significant. Levels of hsCRP over 2 mg/L showed a significant trend of increasing the risk of diabetes. In conclusion, iron may stimulate the expression of pro-inflammatory genes (TNF-alpha and IL-6), and both hepcidin and ferritin gene expression levels could be a risk factor for the development of type 2 diabetes. Subjects that have an increased cardiovascular risk also have a major risk to develop type 2 diabetes, which is independent of the BMI and insulin resistance state.
C1 [Andrews Guzman, Monica; Arredondo Olguin, Miguel] Univ Chile, INTA, Lab Micronutriente, Santiago, Chile.
C3 Universidad de Chile
RP Guzmán, MA (corresponding author), Univ Chile, Inst INTA, El Libano 5524, Santiago, Chile.
EM monica.andrews@gmail.com
RI Andrews, Monica/I-2301-2013
FU Diabetes and Endocrinology Society of Chile (SOCHED); FONDECYT [1085173,
   1110080]
FX This research was supported by the Diabetes and Endocrinology Society of
   Chile (SOCHED) and FONDECYT No 1085173 and 1110080.
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NR 38
TC 9
Z9 9
U1 0
U2 6
PU ARAN EDICIONES, S L
PI MADRID
PA C/ CASTELLO, 128, 1O, MADRID, 28006, SPAIN
SN 0212-1611
EI 1699-5198
J9 NUTR HOSP
JI Nutr. Hosp.
PD SEP
PY 2014
VL 30
IS 3
BP 577
EP 584
DI 10.3305/nh.2014.30.3.7647
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA AQ7AC
UT WOS:000342964000015
PM 25238834
DA 2025-06-11
ER

PT J
AU Eid, BG
   Abdel-Naim, AB
AF Eid, Basma G.
   Abdel-Naim, Ashraf B.
TI Piceatannol Attenuates Testosterone-Induced Benign Prostatic Hyperplasia
   in Rats by Modulation of Nrf2/HO-1/NFκB Axis
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Article
DE piceatannol; HO-1; Nrf-2; benign prostatic hyerplasia; rats
ID OXIDATIVE STRESS; CANCER CELLS; ANTIOXIDANT; PROGRESSION; GROWTH
AB Benign prostatic hyperplasia (BPH) is a serious illness affecting middle-aged and elderly male patients. It is a complication of several diseases including metabolic syndrome. BPH has been associated with inflammation and increased oxidative stress in prostatic tissues. Piceatannol (PIC) is an active natural polyhydroxylated stilbene found in many plants. It has profound anti-inflammatory as well as antioxidant activities. However, it suffers relatively poor pharmacokinetic properties. Nanoformulation is an acknowledged approach to improve PIC bioavailability. The goal was to evaluate the ability of PIC in preventing testosterone-induced benign prostatic hyperplasia in rats. PIC was prepared in a self-nanoemulsifying drug delivery system (SNEDDS). Animals were placed into seven groups: 1) control (vehicle), 2) PIC SNEDDS (20 mg/kg), 3) testosterone (3 mg/kg), 4) testosterone + PIC SNEDDS (5 mg/kg), 5) testosterone + PIC (10 mg/kg), 6) testosterone + PIC SNEDDS (20 mg/kg) and 7) testosterone + finasteride (5 mg/kg). Testosterone was injected SC while PIC SNEDDS and finasteride were given orally. All treatments were given once daily, 5 days/week for four consecutive weeks. PIC administration ameliorated increased prostate weights and indices in addition to histopathological alterations. Further it inhibited accumulation of lipid peroxidation, depletion of glutathione (GSH) and exhaustion of catalase (CAT). PIC SNEDDS exhibited anti-proliferative activities as demonstrated by the inhibition of cyclin D1 protein expression and Bcl2 mRNA expression in addition to enhancement of Bax mRNA expression and caspase-3 content. Immunohistochemically, PIC SNEDDS protected against the testosterone-induced increased expression of tumor necrosis factor alpha (TNF-alpha), interleukin-6 (IL-6), cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), nuclear factor kappa B (NF kappa B) and also offered protection against the decline in Nrf2 expression. Further, a significant enhancement of Nfe212 and Homx1 mRNA expression was detected in PIC SNEDDS-treated animals in comparison to the testosterone group. Conclusively, PIC prepared in SNEDDS protects against experimentally induced BPH via modulation of, at least partly, Nrf2/HO-1/NF kappa B axis.
C1 [Eid, Basma G.; Abdel-Naim, Ashraf B.] King Abdulaziz Univ, Dept Pharmacol & Toxicol, Fac Pharm, Jeddah, Saudi Arabia.
C3 King Abdulaziz University
RP Abdel-Naim, AB (corresponding author), King Abdulaziz Univ, Dept Pharmacol & Toxicol, Fac Pharm, Jeddah, Saudi Arabia.
EM abnaim@yahoo.com
RI Eid, Basma/F-3962-2018; Abdel-Naim, Ashraf/J-3199-2012
FU Deanship of Scientific Research (DSR) at King Abdulaziz University,
   Jeddah [282-166-1441]
FX This project was funded by the Deanship of Scientific Research (DSR) at
   King Abdulaziz University, Jeddah, under Grant no. G: 282-166-1441. The
   authors, therefore, acknowledge with thanks DSR for the technical and
   financial support.
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NR 59
TC 22
Z9 27
U1 0
U2 14
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD DEC 21
PY 2020
VL 11
AR 614897
DI 10.3389/fphar.2020.614897
PG 11
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA PN2DP
UT WOS:000604295500001
PM 33519479
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Martínez-Galán, JP
   Ontibón-Echeverri, CM
   Costa, MC
   Batista-Duharte, A
   Batista, VG
   Mesa, V
   Monti, R
   de Paula, AV
   Baviera, AM
AF Paul Martinez-Galan, Julian
   Maria Ontibon-Echeverri, Catalina
   Costa, Mariana Campos
   Batista-Duharte, Alexander
   Batista, Vinicius Guerso
   Mesa, Victoria
   Monti, Rubens
   de Paula, Ariela Veloso
   Baviera, Amanda Martins
TI Enzymatic synthesis of capric acid-rich structured lipids and their
   effects on mice with high-fat diet-induced obesity
SO FOOD RESEARCH INTERNATIONAL
LA English
DT Article
DE Structured lipids; Enzymatic acidolysis; Lipase; Obesity; Glucose
   intolerance; Oxidative stress; Inflammation
ID GRAPE SEED OIL; SUPERCRITICAL-FLUID EXTRACTION; LINOLEIC-ACID; OXIDATIVE
   STABILITY; INSULIN-RESISTANCE; METABOLIC SYNDROME; CO2 EXTRACTION;
   ADIPOSE-TISSUE; INFLAMMATION; ANTIOXIDANT
AB The objective of this study was to produce structured lipids (SLs) by enzymatic acidolysis using Rhizopus oryzae lipase covalently immobilized in a low-cost material. Grape seed oil was used to synthesize SLs containing the medium-chain fatty acid (C10:0) capric acid. SL synthesis led to 38.8% medium-chain fatty acid incorporation with 5 reuses of the enzymatic derivative. The reaction conditions for the synthesis of MLM-TAGs (triacylglycerols with one long- and two medium-chain acyl residues) were at a molar ratio of fatty acid:oil of 3:1, performed at 40 degrees C and lipase immobilized load of 5% (w/w). The in vivo effects of SLs were studied in Swiss mice fed premade diets: control (C) diet, high-fat diet (HFD) with 100% lipid content as lard, HFD with 50% lipid content as grape seed oil (HG) or HFD with 50% lipid content as capric acid-containing SLs produced from grape seed oil (HG-MCT). Mice from HG and HG-MCT groups had decreases in body weight gain and reductions in the weights of white adipose tissues. In addition, HG and HG-MCT mice had low plasma levels of glucose and total cholesterol, and improvements in the glucose tolerance. HG and HG-MCT diets have remarkable antioxidant properties, since low plasma levels of TBARS (thiobarbituric acid reactive substances, biomarkers of lipid peroxidation) were found in mice fed these diets. Interestingly, TBARS levels in HG-MCT mice were further decreased than values of HG mice. Mice fed HG and HG-MCT diets also showed preservation in the activity of the antioxidant enzyme paraoxonase 1. Both HG and HG-MCT diets promoted reduction of IL-6 and IL-10 production by splenocytes. The capric acid-containing SLs produced from grape seed oil emerges as a functional oil capable to mitigate obesity complications resulting from oxidative stress and inflammation.
C1 [Paul Martinez-Galan, Julian; Maria Ontibon-Echeverri, Catalina; Mesa, Victoria] Univ Antioquia UdeA, Sch Nutr & Dietet, Calle 70 52-21, Medellin, Colombia.
   [Costa, Mariana Campos; Batista-Duharte, Alexander; Baviera, Amanda Martins] Sao Paulo State Univ Unesp, Sch Pharmaceut Sci, Dept Clin Anal, Araraquara, SP, Brazil.
   [Batista, Vinicius Guerso; Monti, Rubens; de Paula, Ariela Veloso] Sao Paulo State Univ Unesp, Sch Pharmaceut Sci, Dept Bioproc Engn & Biotechnol, Araraquara, SP, Brazil.
C3 Universidad de Antioquia; Universidade Estadual Paulista; Universidade
   Estadual Paulista
RP Martínez-Galán, JP (corresponding author), Univ Antioquia UdeA, Sch Nutr & Dietet, Calle 70 52-21, Medellin, Colombia.; Baviera, AM (corresponding author), Sao Paulo State Univ Unesp, Sch Pharmaceut Sci, Dept Clin Anal, Araraquara, SP, Brazil.; de Paula, AV (corresponding author), Sao Paulo State Univ Unesp, Sch Pharmaceut Sci, Dept Bioproc Engn & Biotechnol, Araraquara, SP, Brazil.
EM julian.martinez@udea.edu.co; ariela.veloso@unesp.br;
   amanda.baviera@unesp.br
RI paula, ariela/AAG-7670-2021; Monti, Rubens/C-9214-2012; Baviera,
   Amanda/O-2028-2019; Batista Duharte, Alexander/L-3896-2014; Martinez
   Galan, Julian Paul/Q-4660-2017
OI Batista Duharte, Alexander/0000-0002-1875-0518; Mesa,
   Victoria/0000-0003-2615-7033; Veloso de Paula,
   Ariela/0000-0002-2454-9749; Baviera, Amanda Martins/0000-0003-0987-5295;
   Martinez Galan, Julian Paul/0000-0003-2793-5386
FU Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES),
   Brazil [001]; Fundacao de Amparo a Pesquisa do Estado de Sao Paulo -
   FAPESP [98/09152-6, 2017/11482-7]; Conselho Nacional de Desenvolvimento
   Cientifico e Tecnologico - CNPq [305936/2017-4]; University of Antioquia
   (UdeA) "Fondo de apoyo al primer proyecto" [80/2018 (20187093)];
   Colombian Ministry of Science, Technology and Innovation MINCIENCIAS
   [811/2018]
FX We thank to the University of Antioquia (UdeA) "Fondo de apoyo al primer
   proyecto" CODI 80/2018 (20187093). The Coordenacao de Aperfeicoamento de
   Pessoal de Nivel Superior (CAPES), Brazil-Finance Code 001, Fundacao de
   Amparo a Pesquisa do Estado de Sao Paulo - FAPESP (Grant Numbers
   98/09152-6; 2017/11482-7), and Conselho Nacional de Desenvolvimento
   Cientifico e Tecnologico -CNPq (Grant Number 305936/2017-4) for their
   financial support. We also thank to Colombian Ministry of Science,
   Technology and Innovation MINCIENCIAS (Convocatoria 811/2018 Estancias
   Postdoctorales).
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NR 82
TC 23
Z9 25
U1 1
U2 30
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0963-9969
EI 1873-7145
J9 FOOD RES INT
JI Food Res. Int.
PD OCT
PY 2021
VL 148
AR 110602
DI 10.1016/j.foodres.2021.110602
EA JUL 2021
PG 12
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA UR9AU
UT WOS:000697033500005
PM 34507747
OA Bronze
DA 2025-06-11
ER

PT S
AU Dinda, B
   Dinda, M
   Roy, A
   Dinda, S
AF Dinda, Biswanath
   Dinda, Manikarna
   Roy, Arup
   Dinda, Subhajit
BE Donev, R
TI Dietary plant flavonoids in prevention of obesity and diabetes
SO INFLAMMATORY DISORDERS - PT B
SE Advances in Protein Chemistry and Structural Biology
LA English
DT Review; Book Chapter
ID ACTIVATED PROTEIN-KINASE; IMPROVES GLUCOSE-HOMEOSTASIS; PANCREATIC
   BETA-CELLS; AMELIORATES INSULIN-RESISTANCE; FATTY LIVER-DISEASE;
   SIGNALING PATHWAY; EPIGALLOCATECHIN GALLATE; GREEN TEA;
   METABOLIC-SYNDROME; OXIDATIVE STRESS
AB Obesity and diabetes are the most prevailing chronic metabolic diseases worldwide from mainly lipid and glucose metabolic dysfunctions and their incidence is increasing at an alarming high rate. Obesity is characterized by excess fat accumulation in WAT and liver and is the central player of insulin resistance in the peripheral tissues from chronic inflammation, lipotoxicity and gut dysbiosis, and plays a key role for development of type 2 diabetes (T2DM) and vascular diseases. Diabetes mellitus, known as diabetes, is chiefly characterized by hyperglycaemia from impaired insulin secretion and insulin resistance. Several identified mutant genes in insulin secretion and resistance and various environmental factors are considered responsible for the onset of this disease. Currently available oral synthetic drugs, biguanides, incretin mimetic, GLP-1R and PPAR agonists and DPP-4 inhibitors for management of obesity and diabetes have several adverse effects in patients on long-term use. Emerging evidence supports the efficacy of dietary plant flavonoids in prevention and attenuation of obesity and diabetes by the protection and proliferation of pancreatic beta-cells and improvement of their insulin secretory function via activation of cAMP/PKA signaling pathway as well as in the improvement of insulin sensitivity in the peripheral metabolic tisssues for glucose uptake and utilization via inhibition of inflammation, lipotoxicity and oxidative stress. These flavonoids improve GLUT-4 expression and translocation to plasma membrane by activation of insulin-sensitive PI3K/Akt signaling and insulin-independent AMPK, SIRT-1 and MOR activation pathways for regulation of glucose homeostasis, and improve fat oxidation and reduce lipid synthesis by regulation of related genes for lipid homeostasis in the body of obese diabetic animals. In this chapter, we have highlighted all these beneficial anti-obesity and antidiabetic potentials of some dietary plant flavonoids along with their molecular actions, bioavailability and pharmacokinetics. In addition, the present understanding and management of obesity and diabetes are also focused.
C1 [Dinda, Biswanath] Tripura Univ, Dept Chem, Agartala, Tripura, India.
   [Dinda, Manikarna] Univ Virginia, Dept Biochem & Mol Genet, Charlottesville, VA USA.
   [Roy, Arup] CSIR North East Inst Sci & Technol, Chem Sci & Technol Div, Jorhat, Assam, India.
   [Dinda, Subhajit] Dasaratha Deb Mem Coll, Dept Chem, Khowai, Tripura, India.
C3 Tripura University; University of Virginia; Council of Scientific &
   Industrial Research (CSIR) - India; CSIR - North East Institute of
   Science & Technology (NEIST)
RP Dinda, B (corresponding author), Tripura Univ, Dept Chem, Agartala, Tripura, India.
EM dindabtu@gmail.com
RI Roy, Arup/AAY-3366-2020; DINDA, MANIKARNA/ABB-2631-2021
OI Dinda, Subhajit/0000-0002-6176-9388
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NR 186
TC 71
Z9 74
U1 1
U2 38
PU ELSEVIER ACADEMIC PRESS INC
PI SAN DIEGO
PA 525 B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495 USA
SN 1876-1623
BN 978-0-12-821323-0; 978-0-12-821322-3
J9 ADV PROTEIN CHEM STR
JI Adv. Protein Chem. Struct. Biol.
PY 2020
VL 120
BP 159
EP 235
DI 10.1016/bs.apcsb.2019.08.006
PG 77
WC Biochemistry & Molecular Biology; Immunology
WE Book Citation Index – Science (BKCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Immunology
GA BP0GY
UT WOS:000534287000005
PM 32085882
DA 2025-06-11
ER

PT J
AU Berdaweel, IA
   Monroe, TB
   Alowaisi, AA
   Mahoney, JC
   Liang, IC
   Berns, KA
   Gao, DY
   Mclendon, JM
   Anderson, EJ
AF Berdaweel, Islam A.
   Monroe, T. Blake
   Alowaisi, Amany A.
   Mahoney, Jolonda C.
   Liang, I-Chau
   Berns, Kaitlyn A.
   Gao, Dylan
   Mclendon, Jared M.
   Anderson, Ethan J.
TI Iron scavenging and suppression of collagen cross-linking underlie
   antifibrotic effects of carnosine in the heart with obesity
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Article
DE obesity; cardiac fibrosis; lipid peroxidation; carnosine; iron
   chelation; carbonyl stress; collagen; extracellular matrix
ID LIPID-PEROXIDATION; WESTERN DIET; MYOCARDIAL COLLAGEN; OXIDATIVE STRESS;
   III STIMULATION; END-PRODUCTS; FERROUS IRON; GLYCATION; DISEASE; PROTEIN
AB Oral consumption of histidyl dipeptides such as l-carnosine has been suggested to promote cardiometabolic health, although therapeutic mechanisms remain incompletely understood. We recently reported that oral consumption of a carnosine analog suppressed markers of fibrosis in liver of obese mice, but whether antifibrotic effects of carnosine extend to the heart is not known, nor are the mechanisms by which carnosine is acting. Here, we investigated whether oral carnosine was able to mitigate the adverse cardiac remodeling associated with diet induced obesity in a mouse model of enhanced lipid peroxidation (i.e., glutathione peroxidase 4 deficient mice, GPx4+/-), a model which mimics many of the pathophysiological aspects of metabolic syndrome and T2 diabetes in humans. Wild-type (WT) and GPx4+/-male mice were randomly fed a standard (CNTL) or high fat high sucrose diet (HFHS) for 16 weeks. Seven weeks after starting the diet, a subset of the HFHS mice received carnosine (80 mM) in their drinking water for duration of the study. Carnosine treatment led to a moderate improvement in glycemic control in WT and GPx4+/-mice on HFHS diet, although insulin sensitivity was not significantly affected. Interestingly, while our transcriptomic analysis revealed that carnosine therapy had only modest impact on global gene expression in the heart, carnosine substantially upregulated cardiac GPx4 expression in both WT and GPx4+/-mice on HFHS diet. Carnosine also significantly reduced protein carbonyls and iron levels in myocardial tissue from both genotypes on HFHS diet. Importantly, we observed a robust antifibrotic effect of carnosine therapy in hearts from mice on HFHS diet, which further in vitro experiments suggest is due to carnosine's ability to suppress collagen-cross-linking. Collectively, this study reveals antifibrotic potential of carnosine in the heart with obesity and illustrates key mechanisms by which it may be acting.
C1 [Berdaweel, Islam A.; Monroe, T. Blake; Alowaisi, Amany A.; Mahoney, Jolonda C.; Liang, I-Chau; Berns, Kaitlyn A.; Gao, Dylan; Anderson, Ethan J.] Univ Iowa, Coll Pharm, Dept Pharmaceut Sci & Expt Therapeut, Iowa City, IA 52242 USA.
   [Berdaweel, Islam A.; Alowaisi, Amany A.] Yarmouk Univ, Coll Pharm, Dept Clin Pharm, Irbid, Jordan.
   [Mclendon, Jared M.] Univ Iowa, Carver Coll Med, Dept Internal Med, Iowa City, IA USA.
   [Mclendon, Jared M.; Anderson, Ethan J.] Univ Iowa, Carver Coll Med, Abboud Cardiovasc Res Ctr, Iowa City, IA 52242 USA.
   [Anderson, Ethan J.] Univ Iowa, Carver Coll Med, Fraternal Order Eagles Diabet Res Ctr, Iowa City, IA 52242 USA.
   [Monroe, T. Blake] Univ Minnesota, Dept Biochem, Minneapolis, MN USA.
C3 University of Iowa; Yarmouk University; University of Iowa; University
   of Iowa; University of Iowa; University of Minnesota System; University
   of Minnesota Twin Cities
RP Anderson, EJ (corresponding author), Univ Iowa, Coll Pharm, Dept Pharmaceut Sci & Expt Therapeut, Iowa City, IA 52242 USA.; Anderson, EJ (corresponding author), Univ Iowa, Carver Coll Med, Abboud Cardiovasc Res Ctr, Iowa City, IA 52242 USA.; Anderson, EJ (corresponding author), Univ Iowa, Carver Coll Med, Fraternal Order Eagles Diabet Res Ctr, Iowa City, IA 52242 USA.
EM ethan-anderson@uiowa.edu
RI Berdaweel, Islam/LFU-3154-2024
OI Gao, Dylan/0009-0005-1225-132X; Berdaweel, Islam/0009-0006-2987-458X
FU National Heart, Lung, and Blood Institute10.13039/100000050
FX Authors would like to acknowledge and express gratitude to the faculty
   and staff in the University of Iowa cardiovascular phenotyping and
   histology core facilities for their assistance with cardiac
   structure-function analysis of the mice used in this study, and to the
   Genomics Division for their assistance with mRNA sequencing.
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NR 97
TC 3
Z9 4
U1 2
U2 8
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD JAN 3
PY 2024
VL 14
AR 1275388
DI 10.3389/fphar.2023.1275388
PG 13
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA FQ0G5
UT WOS:001147189500001
PM 38348353
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Deo, P
   Dhillon, VS
   Thomas, P
   Fenech, M
AF Deo, Permal
   Dhillon, Varinderpal S.
   Thomas, Philip
   Fenech, Michael
TI Oleic Acid Status Positively Correlates with the Soluble Receptor for
   Advanced Glycation End-Products (sRAGE) in Healthy Adults Who Are
   Homozygous for G Allele of RAGE G82S Polymorphism
SO CELLS
LA English
DT Article
DE advanced glycation end products (AGEs); soluble receptor for AGEs
   (sRAGE); red blood cell (RBC) fatty acids; monounsaturated fatty acid
   (MUFA)
ID ENDOGENOUS SECRETORY RECEPTOR; MEDITERRANEAN DIET; METABOLIC SYNDROME;
   FATTY-ACIDS; OXIDATIVE STRESS; OLIVE OIL; MOBILIZATION; ROLES; LEVEL;
   CELLS
AB Background: The soluble form of receptor for advanced glycation end products (sRAGE) have been implicated in the prevention of numerous pathologic states, and highlights as an attractive therapeutic target. Because diets rich in monounsaturated fatty acids (MUFA) reduce postprandial oxidative stress and inflammation that is related to better health during aging, we investigated the association between red blood cell (RBC) fatty acids with circulatory AGE biomarkers and further stratified this correlation based on GG and GA + AA genotype. Methods: A total of 172 healthy participants (median age = 53.74 & PLUSMN; 0.61 years) were recruited for the study. RBC fatty acid was analysed using gas chromatography and sRAGE was measured using a commercial ELISA kit. Results: The result showed a non-significant correlation between total MUFA with sRAGE however oleic acid (C18:1) exhibited a positive correlation (r = 0.178, p = 0.01) that remained statistically significant (& beta; = 0.178, p = 0.02) after a stepwise multivariate regression analysis after adjusting for age, BMI and gender. In a univariate analysis, a positive significant correlation between C18:1 and sRAGE in GG genotype (r = 0.169, p = 0.02) and a non-significant correlation with GA + AA genotype (r = 0.192, p = 0.21) was evident. When C18:1 was stratified, a significant difference was observed for oleic acid and G82S polymorphism: low C18:1/GA + AA versus high C18:1/GG (p = 0.015) and high C18:1/GA + AA versus high C18:1/GG (p = 0.02). Conclusion: Our study suggests that increased levels of C18:1 may be a potential therapeutic approach in increasing sRAGE in those with GG genotype and play a role in modulating AGE metabolism.
C1 [Deo, Permal; Dhillon, Varinderpal S.; Fenech, Michael] Univ South Australia, Hlth & Biomed Innovat, UniSA Clin & Hlth Sci, Adelaide 5000, Australia.
   [Thomas, Philip] CSIRO Hlth & Biosecur, Adelaide 5000, Australia.
   [Fenech, Michael] Genome Hlth Fdn, North Brighton 5048, Australia.
C3 University of South Australia; Commonwealth Scientific & Industrial
   Research Organisation (CSIRO)
RP Deo, P (corresponding author), Univ South Australia, Hlth & Biomed Innovat, UniSA Clin & Hlth Sci, Adelaide 5000, Australia.
EM permal.deo@unisa.edu.au
RI Deo, Permal/S-3304-2019; Deo, Permal/D-2930-2011
OI Deo, Permal/0000-0002-6477-9127
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NR 50
TC 3
Z9 3
U1 0
U2 0
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2073-4409
J9 CELLS-BASEL
JI Cells
PD JUN
PY 2023
VL 12
IS 12
AR 1662
DI 10.3390/cells12121662
PG 13
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA K1NI8
UT WOS:001014178600001
PM 37371132
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU da Costa, CS
   Oliveira, TF
   Freitas-Lima, LC
   Padilha, AS
   Krause, M
   Carneiro, MTWD
   Salgado, BS
   Graceli, JB
AF da Costa, Charles S.
   Oliveira, Thiago F.
   Freitas-Lima, Leandro C.
   Padilha, Alessandra S.
   Krause, Maiara
   Carneiro, Maria Tereza W. D.
   Salgado, Breno S.
   Graceli, Jones B.
TI Subacute cadmium exposure disrupts the hypothalamic-pituitary-gonadal
   axis, leading to polycystic ovarian syndrome and premature ovarian
   failure features in female rats
SO ENVIRONMENTAL POLLUTION
LA English
DT Article
DE Cadmium; Endocrine disruptor chemical; Hypothalamic-pituitary-gonadal
   (HPG) axis; Polycystic ovary syndrome (PCOS); Premature ovary failure
   (POF); Uterine abnormalities
ID FOLLICLE DEVELOPMENT; DIAGNOSTIC-CRITERIA; INSULIN-RESISTANCE; METABOLIC
   SYNDROME; OXIDATIVE STRESS; GENE-EXPRESSION; CHLORIDE; ENDOCRINE;
   TOXICITY; HEALTH
AB Cadmium (Cd), a toxic heavy metal, is a known endocrine disruptor that is associated with reproductive complications. However, few studies have explored the effects of Cd exposure on features of polycystic ovary syndrome (PCOS) and premature ovary failure (POF). In this study, we assessed whether doses found in workers occupationally exposed to Cd and subacute exposure result in hypothalamic-pituitarygonadal (HPG) axis and other irregularities. We administered CdCl2 to female rats (100 ppm in drinking water for 30 days) and then assessed Cd levels in the blood, HPG axis and uterus. Metabolic features, HPG axis function, reproductive tract (RT) morphophysiology, inflammation, oxidative stress (OS), and fibrosis were evaluated. Cd exposure increased Cd levels in the serum, HPG axis, and uterus. Cd rats displayed metabolic impairments, such as a reduction in adiposity, dyslipidemia, and insulin resistance (IR). Cd exposure also caused improper functioning in the HPG. Specifically, Cd exposure caused irregular estrous cyclicity, abnormal hypothalamic gene expression (upregulated - Kiss1, AR and mTOR; downregulated - Kiss1R, LepR and THE-alpha), high LH levels, low AMH levels and abnormal ovarian follicular development, coupled with a reduction in ovarian reserve and antral follicle number was observed, suggesting ovarian depletion. Further, Cd exposure caused a reduction in corpora lutea (CL) and granulosa layer thickness together with an increase in cystic/atretic follicles. In addition, Cd exposure caused RT inflammation, OS and fibrosis. Finally, strong positive correlations were observed between serum, RT Cd levels, IR, dyslipidemia and estrous cycle length, cystic, atretic follicles, LH levels, and RT inflammation. Thus, these data suggest that subacute Cd exposure using doses found in workers occupationally exposed to Cd disrupt the HPG axis function, leading to PCOS and POF features and other abnormalities in female rats. (C) 2020 Elsevier Ltd. All rights reserved.
C1 [da Costa, Charles S.; Freitas-Lima, Leandro C.; Graceli, Jones B.] Univ Fed Espirito Santo, Hlth Sci Ctr, Dept Morphol, Av Marechal Campos 1468, BR-29044009 Vitoria, ES, Brazil.
   [Oliveira, Thiago F.; Padilha, Alessandra S.] Univ Fed Espirito Santo, Hlth Sci Ctr, Dept Physiol, Av Marechal Campos 1468, BR-29044009 Vitoria, ES, Brazil.
   [Krause, Maiara; Carneiro, Maria Tereza W. D.] Univ Fed Espirito Santo, Dept Chem, Av Fernando Ferrari,514 Campos,1468, BR-29075910 Vitoria, ES, Brazil.
   [Salgado, Breno S.] Univ Fed Espirito Santo, Hlth Sci Ctr, Dept Pathol, Av Marechal Campos 1468, BR-29044009 Vitoria, ES, Brazil.
C3 Universidade Federal do Espirito Santo; Universidade Federal do Espirito
   Santo; Universidade Federal do Espirito Santo; Universidade Federal do
   Espirito Santo
RP Graceli, JB (corresponding author), Univ Fed Espirito Santo, Dept Morfol CCS, Lab Endocrinol & Toxicol Celular, Av Marechal Campos 1468,Predio Basico 1,Sala 5, BR-29044009 Vitoria, ES, Brazil.
EM chsantoscosta@hotmail.com; lcf.lima@gmail.com; ale_padilha@hotmail.com;
   maiarakrause@gmail.com; mariacarneiro@hotmail.com;
   breno.salgado@ufes.br; jbgraceli@gmail.com
RI Lima, Leandro/I-6425-2012; Bernardes Graceli, Jones/ABC-7439-2021; da
   Costa, Charles/KIL-0401-2024; CARNEIRO, MARIA TEREZA/C-6116-2012
OI Salgado, Breno/0000-0003-3251-6506; Santos da Costa,
   Charles/0000-0003-3616-8211
FU FAPES [03/2017-UNIVERSAL, 179/2017]; CNPq [304724/2017-3, 12/2017,
   304557/2018-8]; FAPES/CNPq [24/2018, 572/2018, 80600115/2017];
   FAPES/CNPq; Bioclin Program (Bioclin-Quibasa)
FX This research was supported by FAPES No 03/2017-UNIVERSAL (#179/2017),
   CNPq (#304724/2017-3/No12/2017, 304557/2018-8), FAPES/CNPq (PRONEX No
   24/2018, #572/2018, 80600115/2017). ELISA and fluorescence analysis were
   performed in LABIOM and LHMI (both at UFES). JBG and ASP awarded grants
   by FAPES/CNPq. Lipid profile kits was supported by Bioclin Program
   (Bioclin-Quibasa). Dr. Jodi Flaws (IL University, USA) for the important
   critical manuscript review.
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NR 83
TC 55
Z9 57
U1 6
U2 44
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0269-7491
EI 1873-6424
J9 ENVIRON POLLUT
JI Environ. Pollut.
PD JAN 15
PY 2021
VL 269
AR 116154
DI 10.1016/j.envpol.2020.116154
PG 14
WC Environmental Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology
GA PN4CS
UT WOS:000604429000079
PM 33280922
DA 2025-06-11
ER

PT J
AU Jósvai, A
   Török, M
   Mátrai, M
   Hetthéssy, J
   Monori-Kiss, A
   Makk, J
   Székács, B
   Nádasy, GL
   Várbíró, S
AF Josvai, Attila
   Torok, Marianna
   Matrai, Mate
   Hetthessy, Judit
   Monori-Kiss, Anna
   Makk, Jennifer
   Szekacs, Bela
   Nadasy, Gyorgy L.
   Varbiro, Szabolcs
TI Effects of Testosterone De ficiency and Angiotensin II-Induced
   Hypertension on the Biomechanics of Intramural Coronary Arteries
SO JOURNAL OF SEXUAL MEDICINE
LA English
DT Article
DE Resistance Coronary Artery; Biomechanics; Castration; Testosterone;
   Hypertension; Rat Andropause Model
ID SEX-DIFFERENCES; METABOLIC SYNDROME; RAT MODEL; DISEASE; ANDROGENS;
   STIFFNESS; MEN; CALCIFICATION; HYPERTROPHY; ESTROGEN
AB Background: Andropause and hypertension also increase the risk of coronary artery damage.
   Aim: To investigate the effect of testosterone deficiency and hypertension on intramural coronary vessels.
   Methods: 4 groups of 8-week-old Sprague-Dawley rats were studied: control male (Co, n=10), orchidectomized male (OCT, n=13), angiotensin (AII) hypertensive male (AII, n=10), and AII hypertensive and OCT (AII + OCT, n=8). Surgical orchidectomy was performed, and an osmotic minipump was inserted for chronic angiotensin II infusion (100 ng/min/kg). After 4 weeks, spontaneous tone and biomechanical properties of the intramural coronary resistance artery were investigated in vitro, by pressure microarteriography.
   Outcomes: Morphology and biomechanics of the intramural coronaries were evaluated: the outer diameter, wall thickness-to-lumen diameter ratio, and tangential wall stress in the contracted and relaxed states.
   Results: The outer diameter was reduced in OCT and AII + OCT groups (on 50 mmHg 315 +/- 20 Co; 237 +/- 21 OCT; 291 +/- 16 AII, and 166 +/- 12 mu m AII + OCT). The increased wall thickness-to-lumen diameter ratio resulted in lower tangential wall stress in AII + OCT rats (on 50 mmHg 19 +/- 2 Co; 24 +/- OCT; 26 +/- 5 AII, and 9 +/- 1 kPa AII + OCT). Spontaneous tone was increased in the hypertensive rats (AII and AII + OCT groups) (on 50 mmHg 7.7 +/- 1.8 Co; 6.1 +/- 1.4 OCT; 14.5 +/- 3.0 AII, and 17.4 +/- 4.1 % AII + OCT).
   Clinical Implications: Andropause alone can be considered as a cardiovascular risk factor that will further exacerbate vascular damage in hypertension.
   Strengths & Limitations: A limitation of our study is that it was performed on relatively young rats, and the conclusions might not apply to coronary remodelling in older animals with slower adaptation processes.
   Conclusions: Testosterone deficiency and hypertension damage the mechanical adaptation of the vessel wall additively: double noxa caused inward eutrophic remodeling and increased tone. Copyright (c) 2020, International Society for Sexual Medicine. Published by Elsevier Inc. All rights reserved.
C1 [Josvai, Attila] Hungarian Def Forces Med Ctr, Dept Neurosurg, Robert Karoly Korut 44, H-1134 Budapest, Hungary.
   [Torok, Marianna; Varbiro, Szabolcs] Semmelweis Univ, Dept Obstet & Gynecol, Budapest, Hungary.
   [Matrai, Mate; Monori-Kiss, Anna; Makk, Jennifer] Semmelweis Univ, Inst Clin Expt Res, Budapest, Hungary.
   [Hetthessy, Judit] Semmelweis Univ, Dept Orthoped, Budapest, Hungary.
   [Szekacs, Bela] Szt Imre Teaching Hosp, Dept Internal Med 2, Dept Sect Geriatr, Budapest, Hungary.
   [Nadasy, Gyorgy L.] Semmelweis Univ, Dept Physiol, Budapest, Hungary.
C3 Semmelweis University; Semmelweis University; Semmelweis University;
   Semmelweis University
RP Jósvai, A (corresponding author), Hungarian Def Forces Med Ctr, Dept Neurosurg, Robert Karoly Korut 44, H-1134 Budapest, Hungary.
EM dr.josvai.attila@gmail.com
RI Török, Marianna/Z-3897-2019
OI BELA, Szekacs/0000-0002-3007-8568
FU Hungarian Hypertension Society; 290 Medical Faculty, Semmelweis
   University; Higher Education Institutional Excellence Program {FIKP} of
   the Semmelweis University
FX This project was supported by grants from the Hungarian Hypertension
   Society and the Dean of the 290 Medical Faculty, Semmelweis University
   (S.V., Gy.L.N.). This study has been supported by the Higher Education
   Institutional Excellence Program {FIKP} of the Semmelweis University
   (M.T.)
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NR 59
TC 1
Z9 1
U1 0
U2 4
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1743-6095
EI 1743-6109
J9 J SEX MED
JI J. Sex. Med.
PD DEC
PY 2020
VL 17
IS 12
BP 2322
EP 2330
DI 10.1016/j.jsxm.2020.09.003
PG 9
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA PD0SH
UT WOS:000597404400002
PM 33067160
DA 2025-06-11
ER

PT J
AU Kaya, C
   Pabuccu, R
   Cengiz, SD
   Dünder, I
AF Kaya, C.
   Pabuccu, R.
   Cengiz, S. D.
   Dunder, I.
TI Comparison Of The Effects Of Atorvastatin And Simvastatin In Women With
   Polycystic Ovary Syndrome: A Prospective, Randomized Study
SO EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
LA English
DT Article
DE PCOS; statin; insulin resistance; testosterone; CRP; MDA
ID C-REACTIVE PROTEIN; THECA-INTERSTITIAL CELLS; CARDIOVASCULAR-DISEASE;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; OXIDATIVE STRESS; ANDROGEN
   LEVELS; INFLAMMATION; PROLIFERATION; HEART
AB Polycystic ovary syndrome (PCOS) is associated with hyperandrogenism, insulin resistance (IR), and chronic inflammation. Simvastatin improves endocrine/clinical aspects of PCOS and decreases systemic inflammation in PCOS. There have been no comparative studies carried out regarding the effects of different statin treatment in PCOS. We aimed to assess the effects of two different statin treatments on various metabolic, endocrine, oxidative and inflammatory factors in PCOS.
   Design: Prospective, randomized clinical trial
   Methods: Sixty-four (64) women with PCOS were included in the study. Group 1 had (atorvastatin, 20lmg daily; n = 32) or group 2 had (simvastatin, 20lmg daily n = 32). The meta bolic, endocrine, inflammatory and oxidative profiles were evaluated.
   Results: Group 1 resulted in a significant reduction in the HOMA index and fasting insulin (-26 .9 +/- 9.6%, -26.2 +/- 10.8%, P < 0.01, respectively). CRP levels decreased by 63.6 +/- 15.9% in group 1 (P < 0.01), whereas in the group 2 it decreased by 34.6 +/- 10.7% (P < 0.05). Serum levels of LH declined by 19.1 +/- 4.5% (P < 0.05) in the group 1 and by 39.3 +/- 11.9% (P < 0.01) in the group 2. FAI decreased by -20 +/- 9.9% in group 1 (P < 0.05) and it decreased by -38.7 +/- 13.8% in the group 2 (P < 0.01). MDA levels decreased by 32.6 +/- 9.6% in group 1 (P < 0.05), whereas in the group 2 it decreased by 30.3 +/- 10.9% (P < 0.01). HOMA index and fasting insulin showed a reduction but not reached statistically significance in the group 2 (8.3 +/- 1.9%, 3.0 +/- 0.8%, P > 0.05, respectively).
   Conclusion: Both the statins are effective in reducing inflammation, hyperandrogenemia, oxidative stress and metabolic parameters. While atorvastatin has more noticeable effects on fasting insulin and insulin sensitivity, simvastatin has a dominant effect on total T in PCOS women.
C1 [Cengiz, S. D.; Dunder, I.] Ankara Univ, Fac Med, Dept Obstet & Gynecol, TR-06100 Ankara, Turkey.
C3 Ankara University
EM kayacemil000@yahoo.com
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NR 36
TC 35
Z9 35
U1 0
U2 4
PU JOHANN AMBROSIUS BARTH VERLAG MEDIZINVERLAGE HEIDELBERG GMBH
PI STUTTGART
PA RUEDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0947-7349
J9 EXP CLIN ENDOCR DIAB
JI Exp. Clin. Endocrinol. Diabet.
PD MAR
PY 2010
VL 118
IS 3
BP 161
EP 166
DI 10.1055/s-0029-1220770
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 579JP
UT WOS:000276366300004
PM 20146169
DA 2025-06-11
ER

PT J
AU Cannon, RO
AF Cannon, Richard O., III
TI Microvascular Angina and the Continuing Dilemma of Chest Pain With
   Normal Coronary Angiograms
SO JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
LA English
DT Article
DE coronary; microcirculation; disease
ID CARDIAC SYNDROME-X; SYNDROME EVALUATION WISE; ARTERY-DISEASE;
   MYOCARDIAL-ISCHEMIA; FOLLOW-UP; ENDOTHELIAL DYSFUNCTION; VASODILATOR
   RESERVE; RISK-FACTORS; L-ARGININE; SUBENDOCARDIAL ISCHEMIA
AB Since initial reports over 4 decades ago, cases of patients with angina-like chest pain whose coronary angiograms show no evidence of obstructive coronary artery disease and who have no structural heart disease continue to be a common occurrence for cardiologists. Many features of this patient population have remained constant with successive reports over time: a female predominance, onset of symptoms commonly between 40 and 50 years of age, pain that is severe and disabling, and inconsistent responses to conventional anti-ischemic therapy. Because patients may have had abnormal noninvasive testing that led to performance of coronary angiography, investigators have sought to show an association of this syndrome with myocardial ischemia. Abnormalities in coronary flow and metabolic responses to stress have been reported by several groups, findings consistent with a microvascular etiology for ischemia and symptoms, but others have questioned the presence of ischemia, even in patients selected for abnormal noninvasive testing. Despite considerable efforts by many groups over 4 decades, the syndrome remains controversial with regard to pathophysiology, diagnosis, and management. (J Am Coll Cardiol 2009; 54:877-85) (C) 2009 by the American College of Cardiology Foundation
C1 NHLBI, Translat Med Branch, NIH, Bethesda, MD 20892 USA.
C3 National Institutes of Health (NIH) - USA; NIH National Heart Lung &
   Blood Institute (NHLBI)
RP Cannon, RO (corresponding author), NHLBI, Translat Med Branch, NIH, Bldg 10 CRC,Room 5-3330,10 Ctr Dr, Bethesda, MD 20892 USA.
EM cannonr@nih.gov
FU National Heart, Lung, and Blood Institute, National Institutes of Health
FX From the Translational Medicine Branch, National Heart, Lung, and Blood
   Institute, National Institutes of Health, Bethesda, Maryland. The
   content of this article represents the opinions of the author and not
   necessarily those of the National Heart, Lung, and Blood Institute. Dr.
   Cannon is supported by the Intramural Research Program of the National
   Heart, Lung, and Blood Institute, National Institutes of Health, and has
   previously served on the Data Safety and Monitoring Board of the WISE
   (Women's Ischemia Syndrome Evaluation) study.
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NR 87
TC 98
Z9 103
U1 0
U2 2
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0735-1097
EI 1558-3597
J9 J AM COLL CARDIOL
JI J. Am. Coll. Cardiol.
PD SEP 1
PY 2009
VL 54
IS 10
BP 877
EP 885
DI 10.1016/j.jacc.2009.03.080
PG 9
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 487WY
UT WOS:000269309900001
PM 19712795
OA Bronze, Green Accepted
DA 2025-06-11
ER

PT J
AU Salami, AT
   Orji, JC
   Akpamu, U
   Iyiola, TO
   Olaleye, SB
AF Salami, A. T.
   Orji, J. C.
   Akpamu, U.
   Iyiola, T. O.
   Olaleye, S. B.
TI Attenuation of Experimental Cholesterol Gallstone Formation by Manganese
   Chloride in Mice: Role of NF-κβ Pathways
SO BIOLOGICAL TRACE ELEMENT RESEARCH
LA English
DT Article; Early Access
DE Cholesterol gallstone; Manganese chloride; Lipid homeostasis;
   Anti-oxidative and hepato-biliary
ID LIPID-PEROXIDATION; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   DIABETES-MELLITUS; OXIDATIVE STRESS; INFLAMMATION; ANTIOXIDANT; DISEASE;
   IRON; ACTIVATION
AB Manganese (Mn), a trace element, has been documented to exert an important role in the metabolism of cholesterol. Cholesterol gallstone (CG) pathogenesis is directly linked to biliary cholesterol imbalance which could be due to diabetes complications or mismanagement. NF-kappa beta pathway, an inflammatory regulator, has been implicated in metabolic disease especially in the context of diabetes and gallstone formation. However, the management of cholesterol gallstones due to diabetes with trace elements is vague. This study investigates the probable role of manganese during CG formation due to diabetes complications. Eighty female Swiss mice were grouped: I (control), II (untreated CG), III and IV (normal mice treated 0.37 mg/kg and 0.74 mg/kg Mn, respectively), V and VI (CG treated 0.37 mg/kg and 0.74 mg/kg Mn, respectively), and VII and VIII (CG treated 75 mg/7 kg and 350 mg/kg aspirin, respectively). Experimental CG was induced with cholesterol-rich diets after alloxan-induced diabetes. On sacrifice, blood collected was evaluated for complete hematological analysis and biochemistry while the excised liver was assayed for biochemical variables. Results were subjected to one-way ANOVA values were expressed as Mean +/- SEM and significant at p <= 0.05. Manganese treatment significantly increased packed cell volume, RBC count, and hemoglobin with decreased platelet and leukocyte counts, liver enzymes (AST, ALT, and ALP), BUN, and creatinine levels in CG groups compared with untreated CG. Blood glucose, plasma low-density lipoproteins, and liver malodialdehyde levels were significantly reduced while liver nitric-oxide, sulfhydryl, and glutathione levels increased significantly in manganese-treated groups compared with untreated CG. Manganese significantly increased fecal iron contents in normal mice by the 2nd week. Hepatocytes and gallbladder histology appear normal in manganese-treated groups. Liver NF-K beta immunoreactivity was downregulated in manganese-treated CG groups. Manganese attenuated experimental hyperglycemia-induced cholesterol gallstone by ameliorating liver oxidative stress and NF-K beta inflammatory pathway.
C1 [Salami, A. T.; Orji, J. C.; Iyiola, T. O.; Olaleye, S. B.] Univ Ibadan, Ibadan, Nigeria.
   [Akpamu, U.] Fed Univ Oye Ekiti, Oye, Nigeria.
C3 University of Ibadan
RP Salami, AT (corresponding author), Univ Ibadan, Ibadan, Nigeria.
EM adeolathabitha@yahoo.com; julietoj34@gmail.com;
   uwaifoh.akpamu@fuoye.edu.ng; toluwalopeiyiola@gmail.com;
   sbolaleye@gmail.com
RI OLALEYE, SAMUEL/AAE-4868-2022
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NR 99
TC 0
Z9 0
U1 1
U2 1
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0163-4984
EI 1559-0720
J9 BIOL TRACE ELEM RES
JI Biol. Trace Elem. Res.
PD 2024 DEC 23
PY 2024
DI 10.1007/s12011-024-04467-z
EA DEC 2024
PG 19
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA Q0S1G
UT WOS:001381882500001
PM 39715976
DA 2025-06-11
ER

PT J
AU Soufer, R
   Fernandez, AB
   Meadows, J
   Collins, D
   Burg, MM
AF Soufer, Robert
   Fernandez, Antonio B.
   Meadows, Judith
   Collins, Dorothea
   Burg, Matthew M.
TI Body Mass Index and Risk for Mental Stress-Induced Ischemia in Coronary
   Artery Disease
SO MOLECULAR MEDICINE
LA English
DT Article
ID LEFT-VENTRICULAR DYSFUNCTION; INDUCED MYOCARDIAL-ISCHEMIA; C-REACTIVE
   PROTEIN; METABOLIC SYNDROME; PSYCHOPHYSIOLOGICAL INVESTIGATIONS;
   ENDOTHELIAL DYSFUNCTION; PSYCHOLOGICAL-FACTORS; ADIPOSE-TISSUE; OBESITY;
   ACTIVATION
AB Acute emotionally reactive mental stress (MS) can provoke prognostically relevant deficits in cardiac function and myocardial perfusion, and chronic inflammation increases risk for this ischemic phenomenon. We have described parasympathetic withdrawal and generation of inflammatory factors in MS. Adiposity is also associated with elevated markers of chronic inflammation. High body mass index (BMI) is frequently used as a surrogate for assessment of excess adiposity and associated with traditional coronary artery disease (CAD) risk factors and CAD mortality. BMI is also associated with autonomic dysregulation and adipose tissue-derived proinflammatory cytokines, which are also attendant to emotion-provoked myocardial ischemia. Thus, we sought to determine if BMI contributes to risk of developing myocardial ischemia provoked by MS. We performed a prospective interventional study in a cohort of 161 patients with stable CAD. They completed an assessment of myocardial blood flow with single-photon emission computed tomography simultaneously during two conditions: laboratory MS and at rest. Multivariate logistic regression determined the independent contribution of BMI to the occurrence of MS-induced ischemia. Mean age was 65.6 +/- 9.0 years, 87.0% had a history of hypertension and 28.6% had diabetes. Mean BMI was 30.4 +/- 4.7. Prevalence of MS ischemia was 39.8%. BMI was an independent predictor of MS ischemia, odds ratio (OR) = 1.10, 95% confidence interval (CI) [1.01-1.18] for 1-point increase in BMI and OR = 1.53, 95% CI [1.06-2.21] for a 4.7-point increase in BMI (one standard deviation beyond the cohort BMI mean), p = 0.025 for all. These data suggest that BMI may serve as an independent risk marker for MS ischemia. The factors attendant with greater BMI, which include autonomic dysregulation and inflammation, may represent pathways by which high BMI contributes to this risk and serves as a conceptual construct to replicate these findings in larger CAD populations.
C1 [Soufer, Robert; Fernandez, Antonio B.; Meadows, Judith; Burg, Matthew M.] Yale Sch Med, Sect Cardiovasc Med, New Haven, CT 06520 USA.
   [Soufer, Robert; Meadows, Judith; Collins, Dorothea; Burg, Matthew M.] VA Connecticut Healthcare Syst, West Haven Campus, West Haven, CT USA.
C3 Yale University; US Department of Veterans Affairs; Veterans Health
   Administration (VHA); VA Connecticut Healthcare System
RP Soufer, R (corresponding author), Yale Univ, Sch Med, VA Connecticut Healthcare Syst, Sect Cardiovasc Med, 950 Campbell Ave 111B, West Haven, CT 06516 USA.
EM Robert.soufer@yale.edu
FU R01 awards from the National Heart, Lung, and Blood Institute
   [HL59619-01, HL071116-01]; Merit Review award from the Department of
   Veterans Affairs
FX This work was supported by R01 awards (HL59619-01 and HL071116-01) from
   the National Heart, Lung, and Blood Institute and by a Merit Review
   award from the Department of Veterans Affairs to Dr. R Soufer. The
   authors would like to acknowledge Dr. Hitender Jain for his
   contributions in organizing the CV Nuclear Medicine Studies for
   evaluation.
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NR 33
TC 5
Z9 6
U1 0
U2 5
PU FEINSTEIN INST MED RES
PI MANHASSET
PA 350 COMMUNITY DR, MANHASSET, NY 11030 USA
SN 1076-1551
EI 1528-3658
J9 MOL MED
JI Mol. Med.
PY 2016
VL 22
BP 286
EP 291
DI 10.2119/molmed.2016.00128
PG 6
WC Biochemistry & Molecular Biology; Cell Biology; Medicine, Research &
   Experimental
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Biochemistry & Molecular Biology; Cell Biology; Research & Experimental
   Medicine
GA DU7HY
UT WOS:000382385900001
PM 27261777
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Baudrand, R
   Gupta, N
   Garza, AE
   Vaidya, A
   Leopold, JA
   Hopkins, PN
   Jeunemaitre, X
   Ferri, C
   Romero, JR
   Williams, J
   Loscalzo, J
   Adler, GK
   Williams, GH
   Pojoga, LH
AF Baudrand, Rene
   Gupta, Nidhi
   Garza, Amanda E.
   Vaidya, Anand
   Leopold, Jane A.
   Hopkins, Paul N.
   Jeunemaitre, Xavier
   Ferri, Claudio
   Romero, Jose R.
   Williams, Jonathan
   Loscalzo, Joseph
   Adler, Gail K.
   Williams, Gordon H.
   Pojoga, Luminita H.
TI Caveolin 1 Modulates Aldosterone-Mediated Pathways of Glucose and Lipid
   Homeostasis
SO JOURNAL OF THE AMERICAN HEART ASSOCIATION
LA English
DT Article
DE aldosterone; caveolin 1; dyslipidemia; eplerenone; insulin resistance;
   mineralocorticoid receptor
ID MINERALOCORTICOID RECEPTOR BLOCKADE; INSULIN-RESISTANCE; METABOLIC
   SYNDROME; OXIDATIVE STRESS; CAVEOLIN-1-DEFICIENT MICE; ADIPOCYTE
   DYSFUNCTION; VASCULAR RELAXATION; ALDOSE REDUCTASE; DIETARY-SODIUM;
   OXIDANT STRESS
AB Background-Overactivation of the aldosterone and mineralocorticoid receptor (MR) pathway is associated with hyperglycemia and dyslipidemia. Caveolin 1 (cav-1) is involved in glucose/lipid homeostasis and may modulate MR signaling. We investigated the interplay between cav-1 and aldosterone signaling in modulating insulin resistance and dyslipidemia in cav-1-null mice and humans with a prevalent variant in the CAV1 gene.
   Methods and Results-In mouse studies, cav-1 knockout mice exhibited higher levels of homeostatic model assessment of insulin resistance, cholesterol, and resistin and lower ratios of high-to low-density lipoprotein (all P<0.001 versus wild type). Moreover, cav-1 knockout mice displayed hypertriglyceridemia and higher mRNA levels for resistin, retinol binding protein 4, NADPH oxidase 4, and aldose reductase in liver and/or fat tissues. MR blockade with eplerenone significantly decreased glycemia (P<0.01), total cholesterol (P<0.05), resistin (P<0.05), and described enzymes, with no effect on insulin or triglycerides. In the human study, we analyzed the CAV1 gene polymorphism rs926198 in 556 white participants; 58% were minor allele carriers and displayed higher odds of insulin resistance (odds ratio 2.26 [95% CI 1.40-3.64]) and low high-density lipoprotein (odds ratio 1.54 [95% CI 1.01-3.37]). Aldosterone levels correlated with higher homeostatic model assessment of insulin resistance and resistin and lower high-density lipoprotein only in minor allele carriers. CAV1 gene expression quantitative trait loci data revealed lower cav-1 expression in adipose tissues by the rs926198 minor allele.
   Conclusions-Our findings in mice and humans suggested that decreased cav-1 expression may activate the effect of aldosterone/MR signaling on several pathways of glycemia, dyslipidemia, and resistin. In contrast, hyperinsulinemia and hypertriglyceridemia are likely mediated by MR-independent mechanisms. Future human studies will elucidate the clinical relevance of MR blockade in patients with genotype-mediated cav-1 deficiency.
C1 [Baudrand, Rene; Gupta, Nidhi; Garza, Amanda E.; Vaidya, Anand; Leopold, Jane A.; Williams, Jonathan; Adler, Gail K.; Williams, Gordon H.; Pojoga, Luminita H.] Harvard Med Sch, Brigham & Womens Hosp, Div Endocrinol Diabet & Hypertens, Dept Med, Boston, MA USA.
   [Leopold, Jane A.; Loscalzo, Joseph] Harvard Med Sch, Brigham & Womens Hosp, Div Cardiovasc Med, Dept Med, Boston, MA USA.
   [Baudrand, Rene] Pontificia Univ Catolica Chile, Dept Endocrinol, Sch Med, Santiago, Chile.
   [Hopkins, Paul N.] Univ Utah, Sch Med, Dept Internal Med, Cardiovasc Genet, Salt Lake City, UT USA.
   [Jeunemaitre, Xavier] Hop Europeen Georges Pompidou, Dept Genet, Ctr Invest Clin Inserm AP, Paris, France.
   [Ferri, Claudio] Univ Aquila, San Salvatore Hosp, Dept MeSVA, Laquila, Italy.
C3 Harvard University; Harvard Medical School; Harvard University Medical
   Affiliates; Brigham & Women's Hospital; Harvard University; Harvard
   Medical School; Harvard University Medical Affiliates; Brigham & Women's
   Hospital; Pontificia Universidad Catolica de Chile; Utah System of
   Higher Education; University of Utah; Assistance Publique Hopitaux Paris
   (APHP); Universite Paris Cite; Hopital Universitaire Europeen
   Georges-Pompidou - APHP; Institut National de la Sante et de la
   Recherche Medicale (Inserm); University of L'Aquila
RP Pojoga, LH (corresponding author), Harvard Med Sch, Brigham & Womens Hosp, Div Endocrinol Diabet & Hypertens, 221 Longwood Ave, Boston, MA 02115 USA.
EM lpojoga@partners.org
RI Ferri, Claudio/AAB-5070-2022; JEUNEMAITRE, Xavier/AAQ-4853-2021;
   Williams, Jonathan/HJA-2081-2022; Leyva Romero, José
   Roberto/KCL-5439-2024; Loscalzo, Joseph/ABD-8980-2021
OI Adler, Gail/0000-0003-3506-7347; Romero, Jose
   Ricardo/0000-0001-8225-0772; Williams, Jonathan/0000-0001-7152-765X;
   Baudrand, Rene/0000-0002-8655-4957
FU NIH [HL104032, HL103845, DK107407, K23HL111771, HL105301, HL096518];
   American Heart Association [14GRNT20500000]; Doris Duke Foundation
   [2015085]; FONDECYT [1150437, 1150327, 1160836, 1160695, CORFO
   13CTI-21526-P1]; American Heart Association (AHA) [14GRNT20500000]
   Funding Source: American Heart Association (AHA)
FX This work was supported by grants from the NIH: HL104032 (Pojoga),
   HL103845 (Adler), DK107407 (Vaidya), K23HL111771 (Vaidya), HL105301
   (Leopold), HL096518 (Romero), from the American Heart Association
   14GRNT20500000 (Pojoga), from the Doris Duke Foundation Grant 2015085
   (Vaidya) and from FONDECYT 1150437 (Baudrand), 1150327 (Baudrand),
   1160836 (Baudrand), 1160695 (Baudrand) and CORFO 13CTI-21526-P1
   (Baudrand).
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NR 67
TC 44
Z9 45
U1 1
U2 8
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2047-9980
J9 J AM HEART ASSOC
JI J. Am. Heart Assoc.
PD OCT
PY 2016
VL 5
IS 10
AR e003845
DI 10.1161/JAHA.116.003845
PG 14
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA EA6OM
UT WOS:000386748500017
PM 27680666
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Kohli, R
   Kirby, M
   Xanthakos, SA
   Softic, S
   Feldstein, AE
   Saxena, V
   Tang, PH
   Miles, L
   Miles, MV
   Balistreri, WF
   Woods, SC
   Seeley, RJ
AF Kohli, Rohit
   Kirby, Michelle
   Xanthakos, Stavra A.
   Softic, Samir
   Feldstein, Ariel E.
   Saxena, Vijay
   Tang, Peter H.
   Miles, Lili
   Miles, Michael V.
   Balistreri, William F.
   Woods, Stephen C.
   Seeley, Randy J.
TI High-Fructose, Medium Chain Trans Fat Diet Induces Liver Fibrosis and
   Elevates Plasma Coenzyme Q9 in a Novel Murine Model of Obesity and
   Nonalcoholic Steatohepatitis
SO HEPATOLOGY
LA English
DT Article
ID HEPATIC STELLATE CELLS; INSULIN-RESISTANCE; LIPID-PEROXIDATION;
   METABOLIC SYNDROME; CORN SYRUP; OB/OB MICE; DISEASE; STEATOSIS;
   CONSUMPTION; RATS
AB Diets high in saturated fat and fructose have been implicated in the development of obesity and nonalcoholic steatohepatitis (NASH) in humans. We hypothesized that mice exposed to a similar diet would develop NASH with fibrosis associated with increased hepatic oxidative stress that would be further reflected by increased plasma levels of the respiratory chain component, oxidized coenzyme Q9 ((ox)CoQ9). Adult male C57Bl/6 mice were randomly assigned to chow, high-fat (HF), or high-fat high-carbohydrate (HFHC) diets for 16 weeks. The chow and HF mice had free access to pure water, whereas the HFHC group received water with 55% fructose and 45% sucrose (wt/vol). The HFHC and HF groups had increased body weight, body fat mass, fasting glucose, and were insulin-resistant compared with chow mice. HF and HFHC consumed similar calories. Hepatic triglyceride content, plasma alanine aminotransferase, and liver weight were significantly increased in HF and HFHC mice compared with chow mice. Plasma cholesterol (P < 0.001), histological hepatic fibrosis, liver hydroxyproline content (P = 0.006), collagen 1 messenger RNA (P = 0.003), CD11b-F4/80+Gr1+ monocytes (P < 0.0001), transforming growth factor beta 1 mRNA (P = 0.04), and alpha-smooth muscle actin messenger RNA (P = 0.001) levels were significantly increased in HFHC mice. Hepatic oxidative stress, as indicated by liver superoxide expression (P = 0.002), 4-hydroxynonenal, and plasma (ox)CoQ9 (P < 0.001) levels, was highest in HFHC mice. Conclusion: These findings demonstrate that nongenetically modified mice maintained on an HFHC diet in addition to developing obesity have increased hepatic ROS and a NASH-like phenotype with significant fibrosis. Plasma (ox)CoQ9 correlated with fibrosis progression. The mechanism of fibrosis may involve fructose inducing increased ROS associated with CD11b+F4/80+Gr1+ hepatic macrophage aggregation, resulting in transforming growth factor beta 1-signaled collagen deposition and histologically visible hepatic fibrosis. (HEPATOLOGY 2010;52:934-944)
C1 [Kohli, Rohit; Kirby, Michelle; Xanthakos, Stavra A.; Softic, Samir; Saxena, Vijay; Balistreri, William F.] Cincinnati Childrens Hosp Med Ctr, Div Gastroenterol Hepatol & Nutr, Dept Pediat, Cincinnati, OH 45229 USA.
   [Tang, Peter H.; Miles, Lili; Miles, Michael V.] Cincinnati Childrens Hosp Med Ctr, Div Pathol & Lab Med, Cincinnati, OH 45229 USA.
   [Woods, Stephen C.] Univ Cincinnati, Coll Med, Dept Psychiat, Cincinnati, OH USA.
   [Seeley, Randy J.] Univ Cincinnati, Coll Med, Dept Med, Div Endocrinol, Cincinnati, OH USA.
   [Feldstein, Ariel E.] Cleveland Clin, Dept Pediat Gastroenterol, Cleveland, OH 44106 USA.
   [Feldstein, Ariel E.] Cleveland Clin, Dept Cell Biol, Cleveland, OH 44106 USA.
C3 Cincinnati Children's Hospital Medical Center; Cincinnati Children's
   Hospital Medical Center; University System of Ohio; University of
   Cincinnati; University System of Ohio; University of Cincinnati;
   Cleveland Clinic Foundation; Cleveland Clinic Foundation
RP Kohli, R (corresponding author), Cincinnati Childrens Hosp Med Ctr, Div Gastroenterol Hepatol & Nutr, Dept Pediat, MLC 2010, Cincinnati, OH 45229 USA.
EM rohit.kohli@cchmc.org
RI BALISTRERI, WILLIAM/LQL-2859-2024; Softic, Samir/ABD-4612-2020; kohli,
   Rohit/H-3020-2013
OI kohli, Rohit/0000-0002-0198-7703; Softic, Samir/0000-0003-1419-9789;
   Miles, Michael/0000-0002-6624-330X; Seeley, Randy/0000-0002-3721-5625
FU National Institute of Child Health and Development [K12 HD028827];
   National Institute of Diabetes and Digestive and Kidney Disorders
   [1K08DK084310]; Children's Digestive Health and Nutrition Foundation;
   Cincinnati Digestive Health Center Public Health Service [P30 DK078392];
   Johnson Johnson
FX Supported by the National Institute of Child Health and Development
   (Grant K12 HD028827 to R. K), the National Institute of Diabetes and
   Digestive and Kidney Disorders (Grant 1K08DK084310 to R. K), the
   Children's Digestive Health and Nutrition Foundation-George Ferry Young
   Investigator Award (to R. K), and Cincinnati Digestive Health Center
   Public Health Service Grant P30 DK078392.Dr. Kohli is a consultant for
   and received grants from Johnson & Johnson. Dr. Seeley is a consultant
   for and is on the speakers' bureau of Amylin Pharmaceuticals. He is also
   on the speakers' bureau of Eli Lilly and Johnson & Johnson. He is on the
   speakers' bureau of Novo Nordick and Merck. He owns stock in Zafgen Inc.
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NR 48
TC 294
Z9 317
U1 2
U2 49
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0270-9139
EI 1527-3350
J9 HEPATOLOGY
JI Hepatology
PD SEP
PY 2010
VL 52
IS 3
BP 934
EP 944
DI 10.1002/hep.23797
PG 11
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 645AJ
UT WOS:000281423000016
PM 20607689
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Paniagua, JA
   López-Miranda, J
   Pérez-Martínez, P
   Marín, C
   Vida, JM
   Fuentes, F
   de la Puebla, RAF
   Pérez-Jiménez, F
AF Paniagua, JA
   López-Miranda, J
   Pérez-Martínez, P
   Marín, C
   Vida, JM
   Fuentes, F
   de la Puebla, RAF
   Pérez-Jiménez, F
TI Oxidized-LDL levels are changed during short-term serum glucose
   variations and lowered with statin treatment in early Type 2 diabetes::
   a study of endothelial function and microalbuminuria
SO DIABETIC MEDICINE
LA English
DT Article
DE endothelium; microalbuminuria; oxidative stress; statin; Type 2 diabetes
ID LOW-DENSITY-LIPOPROTEIN; NITRIC-OXIDE SYNTHASE; INTERCELLULAR-ADHESION
   MOLECULE-1; ACUTE MYOCARDIAL-INFARCTION; ACUTE CORONARY SYNDROMES;
   OXIDATIVE STRESS; INSULIN-RESISTANCE; METABOLIC SYNDROME; IN-VIVO;
   HYPERCHOLESTEROLEMIC MEN
AB Aims To investigate the role of HMG-CoA reductase inhibitor (statin) treatment during serum glucose variations on plasma oxidized LDL (ox-LDL) levels in obese patients with early Type 2 diabetes mellitus (T2D) and its relationship to endothelial biomarkers.
   Methods In a double-blind, randomized crossover study, 15 obese diet-treated T2D patients received cerivastatin (0.4 mg/day) or placebo for 3 months. Circulating ox-LDL levels were measured fasting and during a euglycaemic-hyperinsulinaemic clamp (similar to 5.5 mmol/l; EHC) and a hyperglycemic clamp (similar to 20 mmol/l; HC). An endothelium-dependent flow-mediated dilation (FMD) study was carried out and urinary albumin excretion (UAE) was measured at rest and during EHC. S-ICAM, s-VCAM and basal prothrombotic factors were also measured.
   Results During cerivastatin treatment, basal circulating ox-LDL levels decreased by 48% (P < 0.001) compared with placebo. Serum ox-LDL levels decreased during EHC and remained unchanged during HC compared with the fasting state; with cerivastatin treatment these levels were lower compared with placebo both in the fasting state and during the clamp studies. FMD was higher with cerivastatin than with placebo (P < 0.001) and the increments in FMD correlated with decrements in serum ox-LDL levels (r = 0.78, P = 0.001). Microalbuminuria increased during EHC but this was blunted during cerivastatin therapy compared with placebo (P < 0.05). Basal sICAM-1 and sVCAM-1 levels decreased (P < 0.01 and P < 0.05, respectively).
   Conclusions In early obese Type 2 diabetic patients, serum ox-LDL levels are influenced by short-term serum glucose variations and lowered with cerivastatin therapy. During cerivastatin treatment, improved flow-mediated endothelium-dependent dilation was associated with decrements in circulating ox-LDL levels and the hyperinsulinaemia-induced urinary albumin excretion was blunted.
C1 Hosp Univ Reina Sofia, Lipid & Atherosclerosis Unit, Cordoba 14004, Spain.
   Hosp Univ Reina Sofia, Dept Vasc Radiol, Cordoba 14004, Spain.
C3 Hospital Universitario Reina Sofia - Cordoba; Hospital Universitario
   Reina Sofia - Cordoba
RP Hosp Univ Reina Sofia, Lipid & Atherosclerosis Unit, Avda Menendez Pidal S-N, Cordoba 14004, Spain.
EM jpaniaguag@supercable.es; md1pejif@uco.es
RI Marin Hinojosa, Carmen/AFO-1294-2022; Jimenez, Francisco/AAJ-9559-2021;
   Lopez-Miranda, Jose/Y-8306-2019; Fuentes-Jimenez, Francisco
   Jose/HTM-0138-2023; Vidal-Campello, Juliana/AAS-4595-2020; FUENTES
   JIMENEZ, FRANCISCO/G-4311-2016; Perez Martinez, Pablo/AEL-6176-2022
OI FUENTES JIMENEZ, FRANCISCO/0000-0002-4584-7366; Perez Jimenez,
   Francisco/0000-0001-9808-1280; , Juan A. Paniagua/0000-0003-2892-980X;
   Perez Martinez, Pablo/0000-0001-7716-8117; Perez-Jimenez,
   Francisco/0000-0001-7499-7681; Lopez-Miranda, Jose/0000-0002-8844-0718
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NR 55
TC 18
Z9 20
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0742-3071
EI 1464-5491
J9 DIABETIC MED
JI Diabetic Med.
PD DEC
PY 2005
VL 22
IS 12
BP 1647
EP 1656
DI 10.1111/j.1464-5491.2005.01703.x
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 990AE
UT WOS:000233714800004
PM 16401307
DA 2025-06-11
ER

PT J
AU Zhou, WS
   Shi, W
   Du, XY
   Han, Y
   Tang, Y
   Ri, S
   Ju, K
   Kim, T
   Huang, L
   Zhang, WX
   Yu, YH
   Tian, DD
   Yu, YY
   Chen, LB
   Wu, ZC
   Liu, GX
AF Zhou, Weishang
   Shi, Wei
   Du, Xueying
   Han, Yu
   Tang, Yu
   Ri, Sanghyok
   Ju, Kwangjin
   Kim, Tongchol
   Huang, Lin
   Zhang, Weixia
   Yu, Yihan
   Tian, Dandan
   Yu, Yingying
   Chen, Liangbiao
   Wu, Zhichao
   Liu, Guangxu
TI Assessment of Nonalcoholic Fatty Liver Disease Symptoms and Gut-Liver
   Axis Status in Zebrafish after Exposure to Polystyrene Microplastics and
   Oxytetracycline, Alone and in Combination
SO ENVIRONMENTAL HEALTH PERSPECTIVES
LA English
DT Article
ID INSULIN-RESISTANCE; METABOLIC SYNDROME; ANTIBIOTICS; INFLAMMATION;
   MICROBIOTA; RESIDUES; OBESITY; NAFLD; RISK; EPIDEMIOLOGY
AB BACKGROUND: Environmental pollution may give rise to the incidence and progression of nonalcoholic fatty liver disease (NAFLD), the most common cause for chronic severe liver lesions. Although knowledge of NAFLD pathogenesis is particularly important for the development of effective prevention, the relationship between NAFLD occurrence and exposure to emerging pollutants, such as microplastics (MPs) and antibiotic residues, OBJECTIVES: This study aimed to evaluate the toxicity of MPs and antibiotic residues related to NAFLD occurrence using the zebrafish model METHODS: Taking common polystyrene MPs and oxytetracycline (OTC) as representatives, typical NAFLD symptoms, including lipid accumulation, liver inflammation, and hepatic oxidative stress, were screened after 28-d exposure to environmentally realistic concentrations of MPs (0.69 mg/L) and antibiotic residue (3.00 lg/L). The impacts of MPs and OTC on gut health, the gut-liver axis, and hepatic lipid metabolism were also investigated to reveal potential affecting mechanisms underpinning the NAFLD symptoms observed. RESULTS: Compared with the control fish, zebrafish exposed to MPs and OTC exhibited significantly higher levels of lipid accumulation, triglycerides, and cholesterol contents, as well as inflammation, in conjunction with oxidative stress in their livers. In addition, a markedly smaller proportion of Proteobacteria and higher ratios of Firmicutes/Bacteroidetes were detected by microbiome analysis of gut contents in treated samples. After the exposures, the zebrafish also experienced intestinal oxidative injury and yielded significantly fewer numbers of goblet cells. Markedly higher levels of the intestinal bacteria-sourced endotoxin lipopolysaccharide (LPS) were also detected in serum. Animals treated with MPs and OTC exhibited higher expression levels of LPS binding receptor (LBP) and downstream inflammation-related genes while also exhibiting lower activity and gene expression of lipase. Furthermore, MP-OTC coexposure generally exerted more severe effects compared with single MP or OTC exposure. DISCUSSION: Our results suggested that exposure to MPs and OTC may disrupt the gut-liver axis and be associated with NAFLD occurrence.
C1 [Zhou, Weishang; Shi, Wei; Du, Xueying; Han, Yu; Tang, Yu; Ri, Sanghyok; Ju, Kwangjin; Kim, Tongchol; Huang, Lin; Zhang, Weixia; Yu, Yihan; Tian, Dandan; Yu, Yingying; Liu, Guangxu] Zhejiang Univ, Coll Anim Sci, 866 Yuhangtang Rd, Hangzhou 310058, Peoples R China.
   [Ri, Sanghyok; Kim, Tongchol] Kim Hyong Jik Univ Educ, Coll Life Sci, Pyongyang, North Korea.
   [Ju, Kwangjin] Wonsan Fisheries Univ, Coll Aquaculture, Wonsan, North Korea.
   [Chen, Liangbiao; Wu, Zhichao] Shanghai Ocean Univ, Key Lab Explorat & Utilizat Aquat Genet Resources, Minist Educ, Shanghai, Peoples R China.
C3 Zhejiang University; Shanghai Ocean University; Ministry of Education -
   China
RP Liu, GX (corresponding author), Zhejiang Univ, Coll Anim Sci, 866 Yuhangtang Rd, Hangzhou 310058, Peoples R China.
EM guangxu_liu@zju.edu.cn
RI Shi, Wei/P-2846-2019; Huang, Lin/JKJ-5043-2023; yu,
   yingying/GRR-7851-2022
FU National Key R&D Program of China [2018YFD0900601]; National Natural
   Science Foundation of China [32172944]; Natural Science Foundation of
   Zhejiang Province [LQ21C190003]; Open Fund of Zhejiang Key Laboratory of
   Exploration and Preservation of Costal Bio-resources [J2021001]
FX This work was funded by the National Key R & D Program of China (no.
   2018YFD0900601) , the National Natural Science Foundation of China (no.
   32172944) , the Natural Science Foundation of Zhejiang Province
   (LQ21C190003) , and the Open Fund of Zhejiang Key Laboratory of
   Exploration and Preservation of Costal Bio-resources (J2021001) .
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NR 107
TC 60
Z9 61
U1 80
U2 313
PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE
PI RES TRIANGLE PK
PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233,
   RES TRIANGLE PK, NC 27709-2233 USA
SN 0091-6765
EI 1552-9924
J9 ENVIRON HEALTH PERSP
JI Environ. Health Perspect.
PD APR
PY 2023
VL 131
IS 4
AR 047006
DI 10.1289/EHP11600
PG 14
WC Environmental Sciences; Public, Environmental & Occupational Health;
   Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health; Toxicology
GA E4AD4
UT WOS:000974977600002
PM 37027337
OA gold, Green Published
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Jin, ZQ
   Zheng, E
   Sareli, C
   Kolattukudy, PE
   Niu, JL
AF Jin, Zhuqing
   Zheng, En
   Sareli, Candice
   Kolattukudy, Pappachan E.
   Niu, Jianli
TI Monocyte Chemotactic Protein-Induced Protein 1 (MCPIP-1): A Key Player
   of Host Defense and Immune Regulation
SO FRONTIERS IN IMMUNOLOGY
LA English
DT Review
DE inflammation; viral infection; ischemic inflammation; resolution;
   MCPIP-1
ID NF-KAPPA-B; ZINC-FINGER PROTEIN; ENDOPLASMIC-RETICULUM STRESS;
   TUMOR-SUPPRESSOR GENE; T-CELLS; TRANSCRIPTION FACTOR; OXIDATIVE STRESS;
   INNATE IMMUNITY; MESSENGER-RNAS; STEM-CELLS
AB Inflammatory response is a host-protective mechanism against tissue injury or infections, but also has the potential to cause extensive immunopathology and tissue damage, as seen in many diseases, such as cardiovascular diseases, neurodegenerative diseases, metabolic syndrome and many other infectious diseases with public health concerns, such as Coronavirus Disease 2019 (COVID-19), if failure to resolve in a timely manner. Recent studies have uncovered a superfamily of endogenous chemical molecules that tend to resolve inflammatory responses and re-establish homeostasis without causing excessive damage to healthy cells and tissues. Among these, the monocyte chemoattractant protein-induced protein (MCPIP) family consisting of four members (MCPIP-1, -2, -3, and -4) has emerged as a group of evolutionarily conserved molecules participating in the resolution of inflammation. The focus of this review highlights the biological functions of MCPIP-1 (also known as Regnase-1), the best-studied member of this family, in the resolution of inflammatory response. As outlined in this review, MCPIP-1 acts on specific signaling pathways, in particular NF kappa B, to blunt production of inflammatory mediators, while also acts as an endonuclease controlling the stability of mRNA and microRNA (miRNA), leading to the resolution of inflammation, clearance of virus and dead cells, and promotion of tissue regeneration via its pleiotropic effects. Evidence from transgenic and knock-out mouse models revealed an involvement of MCPIP-1 expression in immune functions and in the physiology of the cardiovascular system, indicating that MCPIP-1 is a key endogenous molecule that governs normal resolution of acute inflammation and infection. In this review, we also discuss the current evidence underlying the roles of other members of the MCPIP family in the regulation of inflammatory processes. Further understanding of the proteins from this family will provide new insights into the identification of novel targets for both host effectors and microbial factors and will lead to new therapeutic treatments for infections and other inflammatory diseases.
C1 [Jin, Zhuqing] Zhejiang Chinese Med Univ, Sch Basic Med Sci, Hangzhou, Zhejiang, Peoples R China.
   [Zheng, En] Zhejiang Univ, Dept Chem, Hangzhou, Zhejiang, Peoples R China.
   [Sareli, Candice; Niu, Jianli] Mem Healthcare Syst, Off Human Res, Hollywood, FL 33021 USA.
   [Kolattukudy, Pappachan E.; Niu, Jianli] Univ Cent Florida, Coll Med, Burnett Sch Biomed Sci, Orlando, FL 32816 USA.
C3 Zhejiang Chinese Medical University; Zhejiang University; State
   University System of Florida; University of Central Florida
RP Niu, JL (corresponding author), Mem Healthcare Syst, Off Human Res, Hollywood, FL 33021 USA.; Niu, JL (corresponding author), Univ Cent Florida, Coll Med, Burnett Sch Biomed Sci, Orlando, FL 32816 USA.
EM jniu@mhs.net
RI kolattukudy, pappachan/A-1350-2012
FU National Natural Science Foundation of China [81774010]
FX This work was supported in part by the National Natural Science
   Foundation of China (Grant No. 81774010).
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NR 132
TC 14
Z9 17
U1 1
U2 11
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-3224
J9 FRONT IMMUNOL
JI Front. Immunol.
PD OCT 1
PY 2021
VL 12
AR 727861
DI 10.3389/fimmu.2021.727861
PG 11
WC Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology
GA WH6FT
UT WOS:000707771700001
PM 34659213
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Nasif, WA
   Mukhtar, MH
   Eldein, MMN
   Ashgar, SS
AF Nasif, Wesam Ahmed
   Mukhtar, Mohammed Hasan
   Eldein, Mohammed Mahmoud Nour
   Ashgar, Sami Sadagah
TI Oxidative DNA damage and oxidized low density lipoprotein in Type II
   diabetes mellitus among patients with Helicobacter pylori
   infection
SO DIABETOLOGY & METABOLIC SYNDROME
LA English
DT Article
DE Helicobacter pylori; Type 2 diabetes mellitus; 8-Hydroxydeoxyguanosine;
   Oxidized low density lipoprotein
ID INSULIN-RESISTANCE; ASSOCIATION; PLASMA; LDL; PREVALENCE; SYMPTOMS;
   STRESS
AB Background: Helicobacter pylori (H. pylori) infection is reported to be associated with various extragastrointestinal conditions such as insulin resistance, diabetes mellitus and metabolic syndrome. H. pylori infection and type 2 diabetes mellitus (T2DM) are associated with oxidative stress, this cross-relation between H. pylori induced infection in T2DM and oxidative damage is still debated. Thus, the question arises whether an increase in the serum level of 8-OHdG and Ox-LDL will occurs in patients with T2DM infected H. pylori; this will be through determination and compare frequency of H. pylori infection in T2DM and non-diabetic patients.
   Methods: 100 patients presented with history of epigastric discomfort for more than 1 month; 50 patients with T2DM and 50 non-diabetics. Anti-H. pylori IgG using ELISA, fasting and postprandial glucose level, glycated hemoglobin (HbA1c) and body mass index (BMI) was calculated. Serum 8-OHdG and Ox-LDL was measured using ELISA for the 100 patients and 50 control subject.
   Results: Rates of H. pylori infection of T2DM and non-diabetic were 66 and 58 %, respectively, (p = 0.001). H. pylori IgG antibody was not correlated with HbA1c either in T2DM (p = 0.06) or non-diabetic (p = 0.25). Serum 8-OHdG level in T2DM with positive H. pylori infection showed a significant difference compared to non-diabetics with positive H. pylori infection (p = 0.001) and higher than that in T2DM with negative H. pylori. A correlation between 8-OHdG concentration and HbA1c in T2DM patients infected with H. pylori was observed (r = 0.39, p = 0.02). Serum Ox-LDL level in T2DM with positive H. pylori infection showed a significant difference compared to diabetics with both negative H. pylori infection and in non-diabetics with positive H. pylori infection (p = 0.001).
   Conclusions: Increased levels of oxidative DNA damage (8-OHdG) and Ox-LDL suggest the mechanistic link between H. pylori infection combined with diabetes and increased generation of ROS and could play as an important image for high risk to atherosclerosis.
C1 [Nasif, Wesam Ahmed; Mukhtar, Mohammed Hasan; Eldein, Mohammed Mahmoud Nour] Umm Al Qura Univ, Fac Med, Dept Biochem, Mecca, Saudi Arabia.
   [Nasif, Wesam Ahmed] Sadat City Univ, Genet Engn & Biotechnol Res Inst, Dept Mol Biol, Sadat City, Egypt.
   [Eldein, Mohammed Mahmoud Nour] Ain Shams Univ, Fac Med, Oncol Diagnost Unit, Cairo, Egypt.
   [Ashgar, Sami Sadagah] Umm Al Qura Univ, Fac Med, Dept Microbiol, Mecca, Saudi Arabia.
C3 Umm Al-Qura University; Egyptian Knowledge Bank (EKB); University of
   Sadat City; Egyptian Knowledge Bank (EKB); Ain Shams University; Umm
   Al-Qura University
RP Nasif, WA (corresponding author), Umm Al Qura Univ, Fac Med, Dept Biochem, Mecca, Saudi Arabia.; Nasif, WA (corresponding author), Sadat City Univ, Genet Engn & Biotechnol Res Inst, Dept Mol Biol, Sadat City, Egypt.
EM wnasif2003@yahoo.com
RI Mukhtar, Mohammed/AGY-4365-2022; Ashgar, Sami/HRB-5227-2023; Mahmoud
   Nour eldein, Mohamed/HIR-3959-2022; Nasif, Wesam/HPE-1237-2023; Ahmed
   Nasif, Wesam/ABE-3153-2020
OI Nasif, Wesam/0000-0002-5119-0137; Mukhtar, Mohammed/0000-0003-0671-2458;
   nour Eldein, Mohamed Mahmoud/0000-0001-6902-2580; Ahmed Nasif,
   Wesam/0009-0001-3351-4812
FU Institute of Scientific Research and Revival of Islamic Culture, Umm
   Al-Qura University, Makkah, KSA [43409027]
FX This research project was supported and funded by the Institute of
   Scientific Research and Revival of Islamic Culture (Grant No. 43409027),
   Umm Al-Qura University, Makkah, KSA.
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NR 52
TC 32
Z9 33
U1 0
U2 14
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1758-5996
J9 DIABETOL METAB SYNDR
JI Diabetol. Metab. Syndr.
PD MAY 3
PY 2016
VL 8
AR 34
DI 10.1186/s13098-016-0149-1
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA DL0SR
UT WOS:000375343400001
PM 27148410
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Yao, JY
   Zhi, M
   Chen, MH
AF Yao, Jiayin
   Zhi, Min
   Chen, Minhu
TI Effect of silybin on high-fat-induced fatty liver in rats
SO BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
LA English
DT Article
DE Non-alcoholic fatty liver disease; Mitochondrial membrane fluidity;
   Lipid peroxidation; Insulin resistance; Silybin
ID NONALCOHOLIC STEATOHEPATITIS; INSULIN-RESISTANCE; MITOCHONDRIAL
   DYSFUNCTION; METABOLIC SYNDROME; NATURAL-HISTORY; DISEASE; ADIPONECTIN;
   SILYMARIN; MODEL; THIAZOLIDINEDIONES
AB Silybin, a natural antioxidant, has been traditionally used against a variety of liver ailments. To investigate its effect and the underlying mechanisms of action on non-alcoholic fatty liver in rats, we used 60 4-6-week-old male Sprague-Dawley rats to establish fatty liver models by feeding a high-fat diet for 6 weeks. Hepatic enzyme, serum lipid levels, oxidative production, mitochondrial membrane fluidity, homeostasis model assessment-insulin resistance index (HOMA-IR), gene and protein expression of adiponectin, and resistin were evaluated by biochemical, reverse transcription polymerase chain reaction (RT-PCR) and Western blot analysis. Compared with the model group, silybin treatment (26.25 mg.kg(-1).day(-1), started at the beginning of the protocol) significantly protected against high-fat-induced fatty liver by stabilizing mitochondrial membrane fluidity, reducing serum content of alanine aminotransferase (ALT) from 450 to 304 U/L, decreasing hepatic malondialdehyde (MDA) from 1.24 to 0.93 nmol/mg protein, but increasing superoxide dismutase (SOD) and glutathione (GSH) levels from 8.03 to 9.31 U/mg protein and from 3.65 to 4.52 nmol/mg protein, respectively. Moreover, silybin enhanced the gene and protein expression of adiponectin from 215.95 to 552.40, but inhibited that of resistin from 0.118 to 0.018. Compared to rosiglitazone (0.5 mg.kg(-1).day(-1), started at the beginning of the protocol), silybin was effective in stabilizing mitochondrial membrane fluidity, reducing SOD as well as ALT, and regulating gene and protein expression of adiponectin (P < 0.05). These results suggest that mitochondrial membrane stabilization, oxidative stress inhibition, as well as improved insulin resistance, may be the essential mechanisms for the hepatoprotective effect of silybin on non-alcoholic fatty liver disease in rats. Silybin was more effective than rosiglitazone in terms of maintaining mitochondrial membrane fluidity and reducing oxidative stress.
C1 [Yao, Jiayin; Zhi, Min] Sun Yat Sen Univ, Affiliated Hosp 6, Dept Gastroenterol, Guangzhou 510655, Guangdong, Peoples R China.
   [Chen, Minhu] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Gastroenterol, Guangzhou 510655, Guangdong, Peoples R China.
C3 Sun Yat Sen University; Sun Yat Sen University
RP Zhi, M (corresponding author), Sun Yat Sen Univ, Affiliated Hosp 6, Dept Gastroenterol, 26th Yuancun 2nd Rd, Guangzhou 510655, Guangdong, Peoples R China.
EM doctorzhimin@163.com
RI Yao, Jiayin/GMW-6023-2022
FU National Natural Science Foundation of China [30600845]; federal office
   of public health of Guangdong Province of China [B2006135]
FX Research supported by a grant from the National Natural Science
   Foundation of China (#30600845) and a grant from the federal office of
   public health of Guangdong Province of China (#B2006135).
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NR 39
TC 55
Z9 65
U1 1
U2 16
PU ASSOC BRAS DIVULG CIENTIFICA
PI SAO PAULO
PA FACULDADE MEDICINA, SALA 21, 14049 RIBEIRAO PRETO, SAO PAULO, 00, BRAZIL
SN 0100-879X
J9 BRAZ J MED BIOL RES
JI Brazilian J. Med. Biol. Res.
PD JUL
PY 2011
VL 44
IS 7
BP 652
EP 659
DI 10.1590/S0100-879X2011007500083
PG 8
WC Biology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics; Research & Experimental
   Medicine
GA 804KC
UT WOS:000293651700007
PM 21755261
OA Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Kim, HJ
   Kim, B
   Mun, EG
   Jeong, SY
   Cha, YS
AF Kim, Hee-Jeong
   Kim, Bohkyung
   Mun, Eun-Gyung
   Jeong, Soon-Yeon
   Cha, Youn-Soo
TI The antioxidant activity of steamed ginger and its protective effects on
   obesity induced by high-fat diet in C57BL/6J mice
SO NUTRITION RESEARCH AND PRACTICE
LA English
DT Article
DE Steamed ginger extract; antioxidant; diet-induced obesity
ID ZINGIBER-OFFICINALE; OXIDATIVE STRESS; METABOLIC SYNDROME; ETHANOLIC
   EXTRACT; CHOLESTEROL; ROOTS; DIFFERENTIATION; INFLAMMATION; POLYPHENOLS;
   RHIZOME
AB BACKGROUND/OBJECTIVES: Ginger, a root vegetable, is known to have antioxidant and antiobesity effects. Preparation, such as by steaming, can affect the chemical composition of prepared root vegetables or herbs and can change their functional activities. In the present study, we investigated the protective effects of steamed ginger against oxidative stress and steatosis in C57BL/6J mice fed a high-fat diet.
   MATERIAL/METHODS: The levels of polyphenols and flavonoids in two different extracts of steamed ginger, i.e., water extract (SGW) and ethanolic extract (SGE); as well, their antioxidant activities were examined. Forty male C57BL/6J mice were fed a normal diet (ND, n = 10), high-fat diet (HFD, 60% fat, w/w, n = 10), HFD supplemented with 200 mg/kg of SGE or garcinia (GAR) by weight (SGED or GARD, respectively, n = 10) for 12 weeks. Serum chemistry was examined, and the expressions of genes involved in lipid metabolism were determined in the liver. Histological analysis was performed to identify lipid accumulations in epididymal fat pads and liver.
   RESULTS: The SGE had higher contents of polyphenols and flavonoids and higher DPPH and ABTS(+) free radical scavenging activities compared to those of SGW. Treatment with SGE or GAR significantly decreased the HFD-induced weight gain. Both SGE and GAR significantly reduced the high serum total cholesterol (TC), triglyceride (TG) and low-density lipoprotein levels induced by HFD. Compared to ND, HFD significantly increased hepatic TC and TG levels. SGE or GAR supplementation significantly decreased the increase of hepatic lipids by HFD. Interestingly, SGE had a more significant effect in reducing hepatic TC and TG levels than GAR. Furthermore, hepatic genes involved in lipogenesis and lipolysis were altered in both the SGED and GARD groups.
   CONCLUSIONS: The present study indicates that steamed ginger supplementation can decrease plasma TC and TG and can inhibit liver steatosis by regulating the expressions of hepatic genes.
C1 [Kim, Hee-Jeong; Mun, Eun-Gyung; Cha, Youn-Soo] Chonbuk Natl Univ, Dept Food Sci & Human Nutr, 567 Baekje Daero, Jeonju 54896, Jeonbuk, South Korea.
   [Kim, Hee-Jeong; Mun, Eun-Gyung; Cha, Youn-Soo] Obes Res Ctr, 567 Baekje Daero, Jeonju 54896, Jeonbuk, South Korea.
   [Kim, Bohkyung] Pusan Natl Univ, Dept Food Sci & Nutr, Busan 46241, South Korea.
   [Jeong, Soon-Yeon] Hlth Local Food Branding Agcy, Jeonbuk 55310, South Korea.
C3 Jeonbuk National University; Pusan National University
RP Cha, YS (corresponding author), Chonbuk Natl Univ, Dept Food Sci & Human Nutr, 567 Baekje Daero, Jeonju 54896, Jeonbuk, South Korea.; Cha, YS (corresponding author), Obes Res Ctr, 567 Baekje Daero, Jeonju 54896, Jeonbuk, South Korea.
EM cha8@jbnu.ac.kr
OI Mun, Eun-Gyung/0000-0001-9476-5773
FU Ministry of Agriculture, Food and Rural Affairs (MAFRA) through the 2015
   Healthy Local Food Branding Project of the Rural Resources Complex
   Industrialization Support Program
FX This work was supported by the Ministry of Agriculture, Food and Rural
   Affairs (MAFRA), through the 2015 Healthy Local Food Branding Project of
   the Rural Resources Complex Industrialization Support Program.
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Z9 29
U1 0
U2 29
PU KOREAN NUTRITION SOC
PI SEOUL
PA 804 KST CTR, 635-4 YEOGSAM-SONG KANGNAM-KU, SEOUL, 135-703, SOUTH KOREA
SN 1976-1457
EI 2005-6168
J9 NUTR RES PRACT
JI Nutr. Res. Pract.
PD DEC
PY 2018
VL 12
IS 6
BP 503
EP 511
DI 10.4162/nrp.2018.12.6.503
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA HN5AJ
UT WOS:000460194500006
PM 30515278
OA Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Jenkins, NT
   Landers, RQ
   Prior, SJ
   Soni, N
   Spangenburg, EE
   Hagberg, JM
AF Jenkins, Nathan T.
   Landers, Rian Q.
   Prior, Steven J.
   Soni, Naina
   Spangenburg, Espen E.
   Hagberg, James M.
TI Effects of acute and chronic endurance exercise on intracellular nitric
   oxide and superoxide in circulating CD34<SUP>+</SUP> and
   CD34<SUP>-</SUP> cells
SO JOURNAL OF APPLIED PHYSIOLOGY
LA English
DT Article
DE stem cells; cardiovascular disease; physical activity
ID ENDOTHELIAL PROGENITOR CELLS; CHRONIC HEART-FAILURE; METABOLIC SYNDROME;
   ANGIOGENIC CELLS; SYNTHASE; CAPACITY; STRESS; RESTORATION; ANGIOBLASTS;
   PHENOTYPE
AB Jenkins NT, Landers RQ, Prior SJ, Soni N, Spangenburg EE, Hagberg JM. Effects of acute and chronic endurance exercise on intracellular nitric oxide and superoxide in circulating CD34(+) and CD34(+) cells. J Appl Physiol 111: 929-937, 2011. First published June 23, 2011; doi: 10.1152/japplphysiol.00541.2011.-We investigated the influence of acute and chronic endurance exercise on levels of intracellular nitric oxide (NO), superoxide (O-2(center dot-)), and expression of genes regulating the balance between these free radicals in CD34(+) and CD34(+) peripheral blood mononuclear cells (PBMCs; isolated by immunomagnetic cell separation). Blood samples were obtained from age-and body mass index (BMI)-matched endurance-trained (n = 10) and sedentary (n = 10) men before and after 30 min of exercise at 75% maximal oxygen uptake ((V) over doto(2max)). Baseline levels of intracellular NO (measured by DAF-FM diacetate) and O-2(center dot-) (measured by dihydroethidium) were 26% (P < 0.05) and 10% (P < 0.05) higher, respectively, in CD34(+) PBMCs from the sedentary group compared with the endurance-trained group. CD34(+) PBMCs from the sedentary group at baseline had twofold greater inducible nitric oxide synthase (iNOS) mRNA and 50% lower endothelial NOS (eNOS) mRNA levels compared with the trained group (P < 0.05). The baseline group difference in O-2(center dot-) was eliminated by acute exercise. Experiments with apocynin indicated that the training-related difference in O-2(center dot-) levels was explained by increased NADPH oxidase activity in the sedentary state. mRNA levels of additional angiogenic and antioxidant genes were consistent with a more angiogenic profile in CD34(+) cells of trained subjects. CD34(+) PBMCs, examined for exploratory purposes, also displayed a more angiogenic mRNA profile in trained subjects, with vascular endothelial growth factor (VEGF) and eNOS being more highly expressed in trained subjects. Overall, our data suggest an association between the sedentary state and increased nitro-oxidative stress in CD34(+) cells.
C1 [Jenkins, Nathan T.; Landers, Rian Q.; Soni, Naina; Spangenburg, Espen E.; Hagberg, James M.] Univ Maryland, Dept Kinesiol, College Pk, MD 20742 USA.
   [Prior, Steven J.] Univ Maryland, Sch Med, Dept Med, Div Gerontol & Geriatr Med, Baltimore, MD 21201 USA.
   [Prior, Steven J.] Baltimore Vet Affairs Geriatr Res, Educ & Clin Ctr, Baltimore, MD USA.
   [Prior, Steven J.] Baltimore Vet Affairs Geriatr Res, Res & Dev Serv, Baltimore, MD USA.
C3 University System of Maryland; University of Maryland College Park;
   University System of Maryland; University of Maryland Baltimore;
   Geriatric Research Education & Clinical Center
RP Hagberg, JM (corresponding author), Univ Maryland, Dept Kinesiol, 2134E Sch Publ Hlth, College Pk, MD 20742 USA.
EM hagberg@umd.edu
RI Prior, Steven/AAC-8232-2020
FU National Institutes of Health [T32-AG-000268]; National Heart, Lung, and
   Blood Institute [R25-HL-092604]; Department of Veterans Affairs
   [CDA-2-0039]; Baltimore Veterans Affairs Medical Center Geriatric
   Research, Education, and Clinical Center; University of Maryland's
   Kinesiology Graduate Research Initiative
FX N. T. Jenkins and R. Q. Landers were supported by National Institutes of
   Health Predoctoral Research Institutional Training Grant T32-AG-000268
   (to J. M. Hagberg). N. Soni was supported by National Heart, Lung, and
   Blood Institute Grant R25-HL-092604 (to J. M. Hagberg). S. J. Prior was
   supported by the Department of Veterans Affairs (CDA-2-0039) and the
   Baltimore Veterans Affairs Medical Center Geriatric Research, Education,
   and Clinical Center. This study was funded by a grant from the
   University of Maryland's Kinesiology Graduate Research Initiative Fund
   (to N. T. Jenkins).
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NR 40
TC 34
Z9 39
U1 0
U2 4
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 8750-7587
J9 J APPL PHYSIOL
JI J. Appl. Physiol.
PD SEP
PY 2011
VL 111
IS 3
BP 929
EP 937
DI 10.1152/japplphysiol.00541.2011
PG 9
WC Physiology; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology; Sport Sciences
GA 817QM
UT WOS:000294688900035
PM 21700895
OA Green Published
DA 2025-06-11
ER

PT J
AU Wu, B
   Qu, YL
   Lu, YF
   Ji, SS
   Ding, L
   Li, Z
   Zhang, M
   Gu, H
   Sun, Q
   Ying, B
   Zhao, F
   Zheng, XL
   Qiu, YD
   Zhang, Z
   Zhu, Y
   Cao, ZJ
   Lv, YB
   Shi, XM
AF Wu, Bing
   Qu, Yingli
   Lu, Yifu
   Ji, Saisai
   Ding, Liang
   Li, Zheng
   Zhang, Miao
   Gu, Heng
   Sun, Qi
   Ying, Bo
   Zhao, Feng
   Zheng, Xulin
   Qiu, Yidan
   Zhang, Zheng
   Zhu, Ying
   Cao, Zhaojin
   Lv, Yuebin
   Shi, Xiaoming
TI Mercury may reduce the protective effect of sea fish consumption on
   serum triglycerides levels in Chinese adults: Evidence from China
   National Human Biomonitoring
SO ENVIRONMENTAL POLLUTION
LA English
DT Article
DE Blood mercury; Triglycerides; Sea fish consumption frequency; Mediation
   analysis
ID NUTRITION EXAMINATION SURVEY; CORONARY-HEART-DISEASE; BLOOD MERCURY;
   CARDIOVASCULAR-DISEASE; SEAFOOD CONSUMPTION; METABOLIC SYNDROME;
   MEDIATION ANALYSIS; OXIDATIVE STRESS; LIPID-METABOLISM; HUMAN HEALTH
AB Sea fish contain omega-3 polyunsaturated fatty acids (omega-3 PUFAs) which have been found to reduce tri-glyceride (TG) levels. However, sea fish may contain pollutants such as mercury which cause oxidative stress and increase TG levels. Therefore, the relationship between sea fish and TG remains unclear. We aimed to explore whether blood mercury (BHg) can affect the effect of sea fish consumption frequency on TG level among Chinese adults. A total of 10,780 participants were included in this study. BHg levels were measured using inductively coupled plasma mass spectrometry (ICP-MS). The associations of sea fish consumption frequency with BHg and TG levels as well as the association of BHg with TG levels were evaluated using multiple linear regression. Causal mediation analysis was used to evaluate the mediation effect of BHg levels on the association of sea fish con-sumption frequency with TG levels. The frequency of sea fish consumption showed a negative association with TG level. Compared with the participants who never ate sea fish, the TG level decreased by 0.193 mmol/L in those who ate sea fish once a week or more [beta (95%CI):-0.193 (-0.370,-0.015)]. Significant positive asso-ciations were observed of BHg with TG levels. With one unit increase of log2-transformed BHg, the change of TG level was 0.030 mmol/L [0.030 (0.009, 0.051)]. The association between sea fish consumption and TG was mediated by log2-transformed BHg [total effect =-0.037 (-0.074,-0.001); indirect effect = 0.009 (0.004, 0.015)], and the proportion mediated by log2-transformed BHg was 24.25%. BHg may reduce the beneficial effect of sea fish consumption frequency on TG levels among Chinese adults. Overall, sea fish consumption has more benefits than harms to TG.
C1 [Wu, Bing; Qu, Yingli; Lu, Yifu; Ji, Saisai; Ding, Liang; Li, Zheng; Zhang, Miao; Gu, Heng; Sun, Qi; Ying, Bo; Zhao, Feng; Zheng, Xulin; Qiu, Yidan; Zhang, Zheng; Zhu, Ying; Cao, Zhaojin; Lv, Yuebin; Shi, Xiaoming] Natl Inst Environm Hlth, Chinese Ctr Dis Control & Prevent, China CDC Key Lab Environm & Populat Hlth, Beijing, Peoples R China.
   [Wu, Bing; Zheng, Xulin; Zhang, Zheng; Shi, Xiaoming] Nanjing Med Univ, Ctr Global Hlth, Sch Publ Hlth, Nanjing, Peoples R China.
   [Qiu, Yidan] Zhejiang Univ, Sch Publ Hlth, Dept Big Data Hlth Sci, Hangzhou, Zhejiang, Peoples R China.
   [Shi, Xiaoming] Natl Inst Environm Hlth, Chinese Ctr Dis Control & Prevent, China CDC Key Lab Environm & Populat Hlth, 7 Panjiayuan Nanli, Chaoyang 100021, Beijing, Peoples R China.
C3 Chinese Center for Disease Control & Prevention; National Institute of
   Environmental Health, Chinese Center for Disease Control & Prevention;
   Nanjing Medical University; Zhejiang University; Chinese Center for
   Disease Control & Prevention; National Institute of Environmental
   Health, Chinese Center for Disease Control & Prevention
RP Shi, XM (corresponding author), Natl Inst Environm Hlth, Chinese Ctr Dis Control & Prevent, China CDC Key Lab Environm & Populat Hlth, Beijing, Peoples R China.; Shi, XM (corresponding author), Nanjing Med Univ, Ctr Global Hlth, Sch Publ Hlth, Nanjing, Peoples R China.; Shi, XM (corresponding author), Natl Inst Environm Hlth, Chinese Ctr Dis Control & Prevent, China CDC Key Lab Environm & Populat Hlth, 7 Panjiayuan Nanli, Chaoyang 100021, Beijing, Peoples R China.
EM shixm@chinacdc.cn
RI Wu, Bing/H-8245-2014; Li, Zi-Ming/ABC-4297-2021; Qiu,
   Yidan/JLM-4662-2023; Shi, Xiaoming/V-2119-2018; Li, Li/AEM-3636-2022
FU National Health Commission Public Health Special Program of China
   [131031108000160004]; Na- tional Natural Science Foundation of China
   [81872707, 82003550]
FX Funding This study was supported by the National Health Commission
   Public Health Special Program of China (131031108000160004) and the Na-
   tional Natural Science Foundation of China (81872707 and 82003550) .
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NR 61
TC 1
Z9 1
U1 3
U2 31
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 0269-7491
EI 1873-6424
J9 ENVIRON POLLUT
JI Environ. Pollut.
PD OCT 15
PY 2022
VL 311
AR 119904
DI 10.1016/j.envpol.2022.119904
EA AUG 2022
PG 10
WC Environmental Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology
GA 4Y1JO
UT WOS:000861288900007
PM 35961572
DA 2025-06-11
ER

PT J
AU Benincasa, G
   Coscioni, E
   Napoli, C
AF Benincasa, Giuditta
   Coscioni, Enrico
   Napoli, Claudio
TI Cardiovascular risk factors and molecular routes underlying endothelial
   dysfunction: Novel opportunities for primary prevention
SO BIOCHEMICAL PHARMACOLOGY
LA English
DT Review
DE Cardiovascular risk factors; Endothelial dysfunction; Epigenetics;
   Biomarkers; Therapeutic targets; Flow-mediated dilation; Primary
   prevention
ID C-REACTIVE PROTEIN; NITRIC-OXIDE SYNTHASE; PERTURBED SHEAR-STRESS;
   MEDITERRANEAN DIET; VASCULAR DYSFUNCTION; DEPENDENT DILATION; METABOLIC
   SYNDROME; GENE-EXPRESSION; ENOS EXPRESSION; MECHANISMS
AB One of the major challenges of cardiovascular primary prevention approach is the absence of early biomarkers of endothelial dysfunction which may be useful for identifying at-risk subjects. Endothelial dysfunction is a systemic disorder in which traditional cardiovascular risk factors, such as aging, gender, hypertension, smoking, hyperglycemia, and dyslipidemia, as well as emerging risk determinants, such as fetal factors, gut microbiome alteration, clonal hematopoiesis, air pollution, and sleep disorders act synergistically to tip the endothelial balance in favor of vasoconstrictive, pro-inflammatory, and pro-thrombotic phenotypes. Endothelial dysfunction can start already in fetal life and may be regained once detrimental stimuli are removed. The hallmark of endothelial dysfunction is a marked reduction of nitric oxide (NO) bioavailability owing to epigenetic-sensitive dysregulation of the endothelial nitric oxide synthase (eNOS) gene and upregulation of reactive oxygen species (ROS) in endothelial cells (ECs). Advance in liquid-based assays and molecular biology tools are providing novel potential EC-specific biomarkers for prediction and diagnosis of endothelial dysfunction. Significant associations between clinically useful indexes of endothelial dysfunction, mainly brachial artery flow-mediated dilation (FMD), and increased number of endothelial microparticles (EMPs), increased levels of endoglin and endocan, as well as reduced levels of irisin were observed in subjects with one or more traditional risk factors. However, none entered in clinical practice yet. Smoking cessation, weight loss, physical exercise, and diet control are the milestones of cardiovascular primary prevention, and they may restore endothelial function via epigenetic-sensitive pathways able to reduce inflammation and oxidative stress and increase NO production . We briefly summarize well-known and novel molecular routes driving early endothelial dysfunction mainly in human ECs and related potential biomarkers which may add predictive or diagnostic value to the traditional non-invasive techniques. Also, we focus on clinical trials investigating lifestyle modifications and their impact on molecular routes involved in restoring endothelial function.
C1 [Benincasa, Giuditta; Napoli, Claudio] Univ Campania Luigi Vanvitelli, Dept Adv Med & Surg Sci DAMSS, I-80138 Naples, Italy.
   [Coscioni, Enrico] AOU San Giovanni Dio & Ruggid Aragona, Div Cardiac Surg, I-84131 Salerno, Italy.
C3 Universita della Campania Vanvitelli
RP Benincasa, G (corresponding author), Univ Campania Luigi Vanvitelli, Dept Adv Med & Surg Sci DAMSS, I-80138 Naples, Italy.
EM giuditta.benincasa@unicampania.it
RI Benincasa, Giuditta/AAB-3951-2021
OI Benincasa, Giuditta/0000-0002-7552-3522
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NR 160
TC 52
Z9 53
U1 3
U2 20
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0006-2952
EI 1873-2968
J9 BIOCHEM PHARMACOL
JI Biochem. Pharmacol.
PD AUG
PY 2022
VL 202
AR 115108
DI 10.1016/j.bcp.2022.115108
EA JUN 2022
PG 15
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 3J5FZ
UT WOS:000833422000001
PM 35643340
DA 2025-06-11
ER

PT J
AU Nabipour, I
   Sambrook, PN
   Blyth, FM
   Janu, MR
   Waite, LM
   Naganathan, V
   Handelsman, DJ
   Le Couteur, DG
   Cumming, RG
   Seibel, MJ
AF Nabipour, Iraj
   Sambrook, Philip N.
   Blyth, Fiona M.
   Janu, Margaret R.
   Waite, Louise M.
   Naganathan, Vasi
   Handelsman, David J.
   Le Couteur, David G.
   Cumming, Robert G.
   Seibel, Markus J.
TI Serum Uric Acid Is Associated With Bone Health in Older Men: A
   Cross-Sectional Population-Based Study
SO JOURNAL OF BONE AND MINERAL RESEARCH
LA English
DT Article
DE URIC ACID; BONE HEALTH; BONE MINERAL DENSITY; BONE TURNOVER; FRACTURE;
   ANTIOXIDANT
ID PSEUDOHYPOPARATHYROIDISM TYPE-IB; MINERAL DENSITY; OXIDATIVE STRESS;
   METABOLIC SYNDROME; RISK-FACTOR; HYPERURICEMIA; OSTEOPOROSIS;
   HYPERTENSION; TERIPARATIDE; EXCRETION
AB Serum uric acid (UA) is a strong endogenous antioxidant. Since oxidative stress has been linked to osteoporosis, we examined the association between serum UA levels and bone mineral density (BMD), prevalent vertebral and nonvertebral fractures, and laboratory measures such as calcitropic hormones and bone turnover marker levels. This cross-sectional analysis consisted of 1705 community-dwelling men aged 70 years or over who participated in the baseline part of the Concord Health and Ageing in Men Project (CHAMP), a population-based study of older men in Sydney, Australia. BMD at all sites was significantly higher among men with serum UA levels above the group median than among men with UA levels below the median. In multiple regression analyses adjusted for potential confounders, serum UA remained associated with BMD at all sites (beta = 0.12 to 0.14, p < .001), serum calcium (beta = 0.11, p = .001), parathyroid hormone (beta = 0.09, p = .002), 25-hydroxyvitamin D (beta = 0.09, p = .005), and was negatively associated with urinary excretion amino-terminal cross-linked telopeptide of type 1 collagen (beta = -0.09, p = .006). Overall, serum UA accounted for 1.0% to 1.44% of the variances in BMD (R-2 = 0.10 to 0.22). In multiple logistic regression analyses, above-median serum UA levels were associated with a lower prevalence of osteoporosis at the femoral neck [odds ratio (OR) = 0.42, 95% confidence interval (CI) 0.22-0.81, p = .010) and lumbar spine (OR = 0.44, 95% CI 0.23-0.86, p = .016) and a lower prevalence of vertebral (OR = 0.62, 95% CI 0.43-0.91, p = .015) and nonvertebral (OR = 0.51, 95% CI 0.29-0.89, p = .018) fractures. In conclusion, higher serum UA levels are associated with higher BMD at all skeletal sites and with a lower prevalence of vertebral and nonvertebral fractures in older men. (C) 2011 American Society for Bone and Mineral Research.
C1 [Nabipour, Iraj; Seibel, Markus J.] Univ Sydney, Bone Res Program, ANZAC Res Inst, Sydney, NSW 2006, Australia.
   [Sambrook, Philip N.] Univ Sydney, Kolling Inst, Royal N Shore Hosp, Sydney, NSW 2006, Australia.
   [Blyth, Fiona M.; Waite, Louise M.; Naganathan, Vasi; Le Couteur, David G.; Cumming, Robert G.] Univ Sydney, Ctr Educ & Res Ageing, Sydney, NSW 2006, Australia.
   [Janu, Margaret R.] Concord Hosp, Sydney SW Pathol Serv, Sydney, NSW, Australia.
   [Handelsman, David J.] Univ Sydney, Dept Androl, ANZAC Res Inst, Sydney, NSW 2006, Australia.
   [Blyth, Fiona M.; Cumming, Robert G.] Univ Sydney, Dept Publ Hlth, Sydney, NSW 2006, Australia.
   [Seibel, Markus J.] Univ Sydney, Dept Endocrinol, Concord Hosp, Sydney, NSW 2006, Australia.
C3 University of Sydney; ANZAC Research Institute; Royal North Shore
   Hospital; University of Sydney; Kolling Institute of Medical Research;
   University of Sydney; Concord Repatriation General Hospital; University
   of Sydney; ANZAC Research Institute; University of Sydney; Concord
   Repatriation General Hospital; University of Sydney
RP Seibel, MJ (corresponding author), Univ Sydney, Bone Res Program, ANZAC Res Inst, Concord Campus, Concord, NSW 2139, Australia.
EM markus.seibel@sydney.edu.au
RI Handelsman, David/AAR-9580-2021; Blyth, Fiona/JDN-3541-2023; nabipour,
   Iraj/D-8924-2017; Cumming, Robert/R-1548-2016
OI Seibel, Markus J/0000-0002-2701-378X; Naganathan,
   Vasikaran/0000-0001-7243-0796; nabipour, Iraj/0000-0002-1785-0883;
   Handelsman, David/0000-0002-4200-7476; Cumming,
   Robert/0000-0002-0261-6103; Waite, Louise/0000-0001-9056-6996; Le
   Couteur, David/0000-0002-4227-5817
FU Amgen; Merck Sharp and Dohme; Novartis; Roche; GlaxoSmithKline;
   Sanofi-Aventis; Servier; Ascend and Bayer Schering; National Health and
   Medical Research Council [301916, 512364, 633224]; Ageing and
   Alzheimer's Research Foundation; Sydney Medical School Foundation;
   Persian Gulf Tropical Medicine Research Center, Bushehr University of
   Medical Science, Bushehr/Iran
FX PNS was supported by and/or has provided consultation to Amgen, Merck
   Sharp and Dohme, Novartis, Roche, GlaxoSmithKline, Sanofi-Aventis, and
   Servier. DJH received support for investigator-initiated research
   studies from Ascend and Bayer Schering (partial funding and funds to the
   research institute). MJS was supported by and/or has provided
   consultation to Amgen, Merck Sharp and Dohme, Novartis, Roche,
   GlaxoSmithKline, Sanofi-Aventis, and Servier. All the other authors
   state that they have no conflicts of interest.We thank Melisa Litchfield
   for her expert technical support, for which no compensation was
   received. This study was supported by the National Health and Medical
   Research Council (Project Grants ID 301916, 512364, and 633224), the
   Ageing and Alzheimer's Research Foundation, and the Sydney Medical
   School Foundation. IN was supported by the Persian Gulf Tropical
   Medicine Research Center, Bushehr University of Medical Science,
   Bushehr/Iran.
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NR 63
TC 113
Z9 134
U1 1
U2 16
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0884-0431
EI 1523-4681
J9 J BONE MINER RES
JI J. Bone Miner. Res.
PD MAY
PY 2011
VL 26
IS 5
BP 955
EP 964
DI 10.1002/jbmr.286
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 762NQ
UT WOS:000290486800008
PM 21541998
OA Bronze
DA 2025-06-11
ER

PT J
AU Carabelli, J
   Burgueño, AL
   Rosselli, MS
   Gianotti, TF
   Lago, NR
   Pirola, CJ
   Sookoian, S
AF Carabelli, Julieta
   Burgueno, Adriana L.
   Soledad Rosselli, Maria
   Fernandez Gianotti, Tomas
   Lago, Nestor R.
   Pirola, Carlos J.
   Sookoian, Silvia
TI High fat diet-induced liver steatosis promotes an increase in liver
   mitochondrial biogenesis in response to hypoxia
SO JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
LA English
DT Article
DE liver; mitochondria; fatty liver; NAFLD; high-fat diet; HIF-1 alpha;
   hypoxia; gene expression; 8-isoprostane; mitochondrial DNA content; type
   1 angiotensin II receptor antagonist; COX4I1; PGC-1 alpha; NRF-1;
   NTF-alpha; PPAR delta
ID RENIN-ANGIOTENSIN SYSTEM; NONALCOHOLIC STEATOHEPATITIS;
   INSULIN-RESISTANCE; HEPATIC STEATOSIS; OXIDATIVE STRESS; DNA CONTENT;
   IN-VIVO; RAT; INJURY; DISEASE
AB Mitochondrial DNA (mtDNA) copy number plays a key role in the pathophysiology of metabolic syndrome-related phenotypes, but its role in non-alcoholic fatty liver disease (NAFLD) is not well understood. We evaluated the molecular mechanisms that may be involved in the regulation of liver mtDNA content in a high-fat-induced rat model of NAFLD. In particular, we tested the hypothesis that liver mtDNA copy number is associated with liver expression of HIF-1 alpha. Rats were given either standard chow diet (SCD, n = 10) or high-fat diet (HFD, n = 15) for 20 weeks. Subsequently, mtDNA quantification using nuclear DNA (nDNA) as a reference was carried out using real time quantitative PCR. HFD induced a significant increase in liver mtDNA/nDNA ratio, which significantly correlated with the liver triglyceride content (R: 0.29, P < 0.05). The liver mtDNA/nDNA ratio significantly correlated with the hepatic expression of HIF-1 alpha mRNA (R: 0.37, P < 0.001); liver HIF-1 alpha mRNA was significantly higher in the HFD group. In addition, liver cytochrome c oxidase subunit IV isoform 1 (COX4I1) mRNA expression was also positively correlated with liver mtDNA content. The hepatic expression of mRNA of transcriptional factors that regulate mitochondrial biogenesis, including peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1 alpha) and PGC-1 beta, nuclear respiratory factor-1 (NRF-1), peroxisome proliferator-activated receptor delta and Tfam, was not associated with the liver mtDNA content. Neither hepatocyte apoptosis nor oxidative stress was involved in the HIF-1 alpha-mediated increase in mtDNA copy number. In conclusion, we found that HFD promotes an increase in liver mitochondrial biogenesis in response to hypoxia via HIF-1 alpha, probably to enhance the mitochondrial function as well as to accommodate the metabolic load.
C1 [Carabelli, Julieta; Soledad Rosselli, Maria; Sookoian, Silvia] Univ Buenos Aires, Inst Med Res A Lanari IDIM, Dept Clin & Mol Hepatol, Natl Council Sci & Technol Res CONICET, RA-1427 Buenos Aires, DF, Argentina.
   [Burgueno, Adriana L.; Fernandez Gianotti, Tomas; Pirola, Carlos J.] Univ Buenos Aires, Inst Med Res A Lanari IDIM, Dept Mol Genet & Biol Complex Dis, Natl Council Sci & Technol Res CONICET, RA-1427 Buenos Aires, DF, Argentina.
   [Lago, Nestor R.] Univ Buenos Aires, Sch Med, Dept Pathol, Ctr Expt Pathol, RA-1427 Buenos Aires, DF, Argentina.
C3 Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET);
   University of Buenos Aires; University of Buenos Aires; Consejo Nacional
   de Investigaciones Cientificas y Tecnicas (CONICET); University of
   Buenos Aires
RP Sookoian, S (corresponding author), Univ Buenos Aires, Inst Invest Med A Lanari CONICET, Combatiente Malvinas 3150, RA-1427 Buenos Aires, DF, Argentina.
EM ssookoian@lanari.fmed.uba.ar
RI Pirola, Carlos/H-2720-2019
OI Lago, Nestor/0000-0002-7633-8687; Pirola, Carlos
   Jose/0000-0001-8234-4058; Fernandez Gianotti, Tomas/0000-0003-2569-9156;
   Carabelli, Julieta/0000-0003-2329-3996; Burgueno, Adriana
   L./0000-0001-7584-7044
FU Agencia Nacional de Promocion Cientifica y Tecnologica [PICT 2006-124];
   Universidad de Buenos Aires [UBACYT M055]
FX This study was partially supported by the grants PICT 2006-124 (Agencia
   Nacional de Promocion Cientifica y Tecnologica) and UBACYT M055
   (Universidad de Buenos Aires). A.B., M.S.R., T.F.G., C.J.P. and S.S. are
   members of Consejo Nacional de Investigaciones Cientificas.
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NR 40
TC 96
Z9 104
U1 0
U2 22
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
EI 1582-4934
J9 J CELL MOL MED
JI J. Cell. Mol. Med.
PD JUN
PY 2011
VL 15
IS 6
BP 1329
EP 1338
DI 10.1111/j.1582-4934.2010.01128.x
PG 10
WC Cell Biology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Research & Experimental Medicine
GA 769ZX
UT WOS:000291057900009
PM 20629985
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Wang, XH
   Liu, W
   Li, HL
   Ding, JX
   Feng, Y
   Chen, ZJ
AF Wang, Xuehua
   Liu, Wei
   Li, Huili
   Ding, Jiaxing
   Feng, Yu
   Chen, Zhijian
TI Exploring the Role of Obesity in Dilated Cardiomyopathy Based on
   Bio-informatics Analysis
SO JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
LA English
DT Article
DE dilated cardiomyopathy; obesity; bio-informatics analysis; GEO; LASSO
ID BODY-MASS INDEX; METABOLIC SYNDROME; OXIDATIVE STRESS; IMPACT; FUTURE;
   CELLS; GAMMA; RISK
AB (1) Background: Obesity is a major risk factor for cardiovascular disease (CVD), contributing to increasing global disease burdens. Apart from heart failure, coronary artery disease, and arrhythmia, recent research has found that obesity also elevates the risk of dilated cardiomyopathy (DCM). The main purpose of this study was to investigate the underlying biological role of obesity in increasing the risk of DCM. (2) Methods: The datasets GSE120895, GSE19303, and GSE2508 were downloaded from the Gene Expression Omnibus (GEO) database. Differentially expressed genes (DEGs) were analyzed using GSE120895 for DCM and GSE2508 for obesity, and the findings were compiled to discover the common genes. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were conducted for the common genes in RStudio. In addition, CIBERSORT was used to obtain the immune cellular composition from DEGs. The key genes were identified in the set of common genes by the least absolute shrinkage and selection operator (LASSO) algorithm, the prognostic risk models of which were verified by receiver operator characteristic (ROC) curves in GSE19303. Finally, Spearman's correlation was used to explore the connections between key genes and immune cells. (3) Results: GO and KEGG pathway enrichment analyses showed that the main enriched terms of the common genes were transforming growth factor-beta (TGF-beta), fibrillar collagen, NADPH oxidase activity, and multiple hormone-related signaling pathways. Both obesity and DCM had a disordered immune environment, especially obesity. The key genes NOX4, CCDC80, COL1A2, HTRA1, and KLHL29 may be primarily responsible for the changes. Spearman's correlation analysis performed for key genes and immune cells indicated that KLHL29 closely correlated to T cells and M2 macrophages, and HTRA1 very tightly correlated to plasma cells. (4) Conclusions: Bio-informatics analyses performed for DCM and obesity in our study suggested that obesity disturbed the immune micro-environment, promoted oxidative stress, and increased myocardial fibrosis, resulting in ventricular remodeling and an increased risk of DCM. The key genes KLHL29 and HTRA1 may play critical roles in obesity-related DCM.
C1 [Wang, Xuehua; Liu, Wei; Li, Huili; Ding, Jiaxing; Feng, Yu; Chen, Zhijian] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Cardiol, Wuhan 430022, Peoples R China.
   [Wang, Xuehua; Liu, Wei; Li, Huili; Ding, Jiaxing; Feng, Yu; Chen, Zhijian] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Hubei Key Lab Biol Targeted Therapy, Wuhan 430022, Peoples R China.
   [Wang, Xuehua; Liu, Wei; Li, Huili; Ding, Jiaxing; Feng, Yu; Chen, Zhijian] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Hubei Prov Engn Res Ctr Immunol Diag & Therapy Car, Wuhan 430022, Peoples R China.
   [Liu, Wei] Wuhan Fourth Hosp, Dept Cardiol, Wuhan 430033, Peoples R China.
C3 Huazhong University of Science & Technology; Huazhong University of
   Science & Technology; Huazhong University of Science & Technology
RP Chen, ZJ (corresponding author), Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Cardiol, Wuhan 430022, Peoples R China.; Chen, ZJ (corresponding author), Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Hubei Key Lab Biol Targeted Therapy, Wuhan 430022, Peoples R China.; Chen, ZJ (corresponding author), Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Hubei Prov Engn Res Ctr Immunol Diag & Therapy Car, Wuhan 430022, Peoples R China.
EM drchenzhijian@hust.edu.cn
RI Chen, Zhijian/HNO-8820-2023; Liu, Wei/LIA-8140-2024
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NR 57
TC 3
Z9 4
U1 2
U2 12
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2308-3425
J9 J CARDIOVASC DEV DIS
JI J. Cardiovasc. Dev. Dis.
PD DEC
PY 2022
VL 9
IS 12
AR 462
DI 10.3390/jcdd9120462
PG 14
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 7E7QN
UT WOS:000901357600001
PM 36547458
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Garcez, ML
   Bellettini-Santos, T
   Schiavo, GL
   Calixto, KV
   Mina, F
   Medeiros, EB
   Zabot, GC
   Pereira, ND
   do Nascimento, NB
   Tomaz, DB
   Alexandre, MCM
   Kucharska, E
   Rico, EP
   Budni, J
AF Garcez, Michelle Lima
   Bellettini-Santos, Tatiani
   Schiavo, Gustavo Luis
   Calixto, Karen Vasconcelos
   Mina, Francielle
   Medeiros, Eduarda Behenck
   Zabot, Gabriel Casagrande
   Pereira, Nathalia de Souza
   do Nascimento, Natalia Baltazar
   Tomaz, Debora Borges
   Manenti Alexandre, Maria Cecilia
   Kucharska, Ewa
   Rico, Eduardo Pacheco
   Budni, Josiane
TI Long-term administration of soft drink causes memory impairment and
   oxidative damage in adult and middle-aged rats
SO EXPERIMENTAL GERONTOLOGY
LA English
DT Article
DE Soft drink; Cola; Memory; Oxidative stress; Rat
ID SUGAR-SWEETENED BEVERAGES; SPATIAL MEMORY; DIFFERENTIAL SENSITIVITY;
   CONSUMPTION; SUCROSE; TASK; PERFORMANCE; PLASTICITY; INSULIN
AB Introduction: The consumption of soft drinks has increased considerably in recent decades, mainly cola soft drinks. Excessive consumption of cola-based soft drinks is associated with several diseases and cognitive decline, particularly memory impairment. Furthermore, diets with high sugar can promote insulin resistance, metabolic syndrome, and dyslipidemia.
   Aim: Thus, the present study aimed to evaluate the effect of cola soft drink intake on behavioral alterations and oxidative damage in 2-, 8- and 14- month-old male Wistar rats.
   Methods: The soft drink groups drank soft drink and/or water ad libitum during 67 days, the control groups ingested only water. Radial-arm maze and Y-maze were used to evaluate spatial memory, open-field to evaluate the habituation memory, and inhibitory avoidance to evaluate aversive memory. The behavioral tests started at the day 57 and finished at day 67 of treatment. At 68th day, the rats were killed; frontal cortex and hippocampus were dissected to the analysis of antioxidants enzymes catalase (CAT) and superoxide dismutase (SOD); and the oxidative markers thiobarbituric acid reactive substances (TBARS) and dichlom-dihydro-fluorescein diacetate (DCFH) were measured in the hippocampus.
   Results and discussion: The cola-based soft drink intake caused memory impairment in the radial-arm maze, Y-maze task, and open-field in the 2- and 8-month-old rat, but not in the 14-month-old. There were no difference among groups in the inhibitory avoidance test. In the frontal cortex, soft drink intake reduced CAT activity in the 8-month-old rats and SOD activity in the 8- and 14-month-old rats. In the hippocampus, the soft drink increased CAT activity in 2- and 8-month-old rats, increased DCFH levels at all ages, and increased TBARS levels in 2-month-rats. Therefore, the results show that long-term soft drink intake leads to memory impairment and oxidative stress. The younger seems to be more susceptible to the soft drink alterations on behavior; however, soft drink caused alterations in the oxidative system at all ages evaluated.
C1 [Garcez, Michelle Lima] Fed Univ Santa Catarina UFSC, Dept Biochem, Lab Translat Neurosci, Florianopolis, SC, Brazil.
   [Garcez, Michelle Lima; Bellettini-Santos, Tatiani; Calixto, Karen Vasconcelos] Univ Ctr Espirito Santo, Grad Program Res & Extens CEPEG, Vitoria, ES, Brazil.
   [Schiavo, Gustavo Luis; Calixto, Karen Vasconcelos; Mina, Francielle; Medeiros, Eduarda Behenck; Zabot, Gabriel Casagrande; Pereira, Nathalia de Souza; do Nascimento, Natalia Baltazar; Tomaz, Debora Borges; Manenti Alexandre, Maria Cecilia; Rico, Eduardo Pacheco; Budni, Josiane] Univ Southern Santa Catarina UNESC, Lab Expt Neurol, Grad Program Hlth Sci, BR-88806000 Criciuma, SC, Brazil.
   [Kucharska, Ewa] Jesuit Univ Ignatianum Krakow, Fac Educ, Inst Educ Sci, Krakow, Poland.
C3 Universidade Federal de Santa Catarina (UFSC); Universidade do Sul de
   Santa Catarina
RP Budni, J (corresponding author), Univ Southern Santa Catarina UNESC, Lab Expt Neurol, Grad Program Hlth Sci, BR-88806000 Criciuma, SC, Brazil.
EM josiane.budni@unesc.net
RI Pereira, Nathalia/KHX-5019-2024; Budni, Josiane/M-4382-2013; Kucharska,
   Ewa/H-5802-2018; Bellettini dos Santos, Tatiani/ABA-4068-2021; Garcez,
   Michelle/I-7564-2018
OI Medeiros, Eduarda/0000-0002-4955-5301; Baltazar,
   Natalia/0000-0001-6820-7452; Bellettini dos Santos,
   Tatiani/0000-0003-4302-1197; Garcez, Michelle/0000-0003-4333-5241
FU National Council for Scientific and Technological Development
   (CNPq-Brazil); Laboratory of Experimental Neurology from University of
   Southern Santa Catarina (UNESC); Conselho Nacional de Desenvolvimento
   Cientifico e Tecnologico (CNPq); Coordenacao de Aperfeicoamento de
   Pessoal de Nivel Superior (CAPES); Fundacao de Amparo a Pesquisa e
   Inovacao do Estado de Santa Catarina (FAPESC); UNESC; L'Oreal Brasil,
   Unesco Brazil
FX The authors are thankful to the National Council for Scientific and
   Technological Development (CNPq-Brazil) for the first author's research
   fellowship (PDJ) at Federal University of Santa Catarina (UFSC).
   Laboratory of Experimental Neurology from University of Southern Santa
   Catarina (UNESC) supported this study. Laboratory of Experimental
   Neurology (Brazil) is funded by grants from Conselho Nacional de
   Desenvolvimento Cientifico e Tecnologico (CNPq), Coordenacao de
   Aperfeicoamento de Pessoal de Nivel Superior (CAPES), Fundacao de Amparo
   a Pesquisa e Inovacao do Estado de Santa Catarina (FAPESC), UNESC and
   "For Women in Science" performed by L'Oreal Brasil, Unesco Brazil e ABC
   (Brazilian Academy of Sciences) 2019 Award. JB is CNPq Research Fellow.
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NR 53
TC 4
Z9 4
U1 4
U2 11
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0531-5565
EI 1873-6815
J9 EXP GERONTOL
JI Exp. Gerontol.
PD SEP
PY 2022
VL 166
AR 111873
DI 10.1016/j.exger.2022.111873
EA JUL 2022
PG 9
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA 5V8NZ
UT WOS:000877482300004
PM 35760268
DA 2025-06-11
ER

PT J
AU Peng, C
   Stewart, AG
   Woodman, OL
   Ritchie, RH
   Qin, CX
AF Peng, Cheng
   Stewart, Alastair G.
   Woodman, Owen L.
   Ritchie, Rebecca H.
   Qin, Cheng Xue
TI Non-Alcoholic Steatohepatitis: A Review of Its Mechanism, Models and
   Medical Treatments
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Review
DE animal models; pharmacological treatments; metabolic syndrome; obesity;
   non-alcoholic fatty liver disease; non-alcoholic steatohepatitis;
   steatosis
ID FATTY LIVER-DISEASE; ACTIVATED-RECEPTOR-ALPHA; NECROSIS-FACTOR-ALPHA;
   DE-NOVO LIPOGENESIS; NF-KAPPA-B; SERUM ALANINE AMINOTRANSFERASE;
   ENDOPLASMIC-RETICULUM STRESS; ALPHA/DELTA AGONIST GFT505; HEPATIC
   INSULIN-RESISTANCE; LIFE-STYLE MODIFICATION
AB Non-alcoholic steatohepatitis (NASH) develops from non-alcoholic fatty liver disease (NAFLD). Currently, around 25% of the population is estimated to have NAFLD, and 25% of NAFLD patients are estimated to have NASH. NASH is typically characterized by liver steatosis inflammation, and fibrosis driven by metabolic disruptions such as obesity, diabetes, and dyslipidemia. NASH patients with significant fibrosis have increased risk of developing cirrhosis and liver failure. Currently, NASH is the second leading cause for liver transplant in the United States. More importantly, the risk of developing hepatocellular carcinoma from NASH has also been highlighted in recent studies. Patients may have NAFLD for years before progressing into NASH. Although the pathogenesis of NASH is not completely understood, the current "multiple-hits" hypothesis suggests that in addition to fat accumulation, elevated oxidative and ER stress may also drive liver inflammation and fibrosis. The development of clinically relevant animal models and pharmacological treatments for NASH have been hampered by the limited understanding of the disease mechanism and a lack of sensitive, non-invasive diagnostic tools. Currently, most pre-clinical animal models are divided into three main groups which includes: genetic models, diet-induced, and toxin + diet-induced animal models. Although dietary models mimic the natural course of NASH in humans, the models often only induce mild liver injury. Many genetic and toxin + diet-induced models rapidly induce the development of metabolic disruption and serious liver injury, but not without their own shortcomings. This review provides an overview of the "multiple-hits" hypothesis and an evaluation of the currently existing animal models of NASH. This review also provides an update on the available interventions for managing NASH as well as pharmacological agents that are currently undergoing clinical trials for the treatment of NASH.
C1 [Peng, Cheng; Woodman, Owen L.; Ritchie, Rebecca H.; Qin, Cheng Xue] Monash Inst Pharmaceut Sci, Drug Discovery Biol, Melbourne, Vic, Australia.
   [Peng, Cheng; Ritchie, Rebecca H.; Qin, Cheng Xue] Baker Heart & Diabet Inst, Melbourne, Vic, Australia.
   [Peng, Cheng; Stewart, Alastair G.; Ritchie, Rebecca H.; Qin, Cheng Xue] Univ Melbourne, Dept Pharmacol & Therapeut, Melbourne, Vic, Australia.
   [Stewart, Alastair G.] Australian Res Council, Ctr Personalised Therapeut Technol, Lancaster, CBR, Australia.
C3 Baker Heart and Diabetes Institute; University of Melbourne
RP Qin, CX (corresponding author), Monash Inst Pharmaceut Sci, Drug Discovery Biol, Melbourne, Vic, Australia.; Qin, CX (corresponding author), Baker Heart & Diabet Inst, Melbourne, Vic, Australia.; Qin, CX (corresponding author), Univ Melbourne, Dept Pharmacol & Therapeut, Melbourne, Vic, Australia.
EM helena.qin@monash.edu
RI Ritchie, Rebecca/E-7392-2011; Woodman, Owen/H-7297-2019; Stewart,
   Alastair/A-7182-2012
OI Ritchie, Rebecca/0000-0002-8610-0058; Qin, Chengxue/0000-0003-2169-2686
FU CASS Foundation; Victoria Medical Acceleration Grant; Victorian
   Government's Operational Infrastructure Support Program; National Health
   and Medical Research Council (NHMRC) of Australia [1059960, 1158013];
   Victorian Medical Research Acceleration Fund; National Health and
   Medical Research Council of Australia [1158013, 1059960] Funding Source:
   NHMRC
FX This work was supported in part by the CASS Foundation (CXQ), Victoria
   Medical Acceleration Grant (RHR), and the Victorian Government's
   Operational Infrastructure Support Program. RHR was supported by the
   National Health and Medical Research Council (NHMRC) of Australia
   (ID1059960, ID1158013), and CXQ is Australia National Heart Foundation
   Future Fellow. Victorian Medical Research Acceleration Fund (RR, CXQ,
   AGS).
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NR 241
TC 157
Z9 172
U1 13
U2 63
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD DEC 3
PY 2020
VL 11
AR 603926
DI 10.3389/fphar.2020.603926
PG 22
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA PG0BR
UT WOS:000599410000001
PM 33343375
OA Green Published, gold
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Trasande, L
   Urbina, EM
   Khoder, M
   Alghamdi, M
   Shabaj, I
   Alam, MS
   Harrison, RM
   Shamy, M
AF Trasande, Leonardo
   Urbina, Elaine M.
   Khoder, Mamdouh.
   Alghamdi, Mansour
   Shabaj, Ibrahim
   Alam, Mohammed S.
   Harrison, Roy M.
   Shamy, Magdy
TI Polycyclic aromatic hydrocarbons, brachial artery distensibility and
   blood pressure among children residing near an oil refinery
SO ENVIRONMENTAL RESEARCH
LA English
DT Article
DE Polycyclic aromatic hydrocarbons; Particulate matter; Prehypertension;
   Brachial artery distensibility; Adolescents
ID PARTICULATE AIR-POLLUTION; OXIDATIVE STRESS; UNITED-STATES;
   RISK-FACTORS; METABOLIC SYNDROME; US CHILDREN; DISEASE; MORTALITY;
   EXPOSURE; NICKEL
AB Background: Polycyclic aromatic hydrocarbons (PAH) are produced by the burning and processing of fuel oils, and have been associated with oxidant stress, insulin resistance and hypertension in adults. Few studies have examined whether adolescents are susceptible to cardiovascular effects of PAHs.
   Objective: To study associations of PAH exposure with blood pressure (BP) and brachial artery distensibility (BAD), an early marker of arterial wall stiffness, in young boys attending three schools in Jeddah, Saudi Arabia in varying proximity to an oil refinery. Methods: Air samples collected from the three schools were analyzed for PAHs. PAH metabolites (total hydroxyphenanthrenes and 1-hydroxypyrene) were measured in urine samples from 184 adolescent males, in whom anthropometrics, heart rate, pulse pressure, brachial artery distensibility and blood pressure were measured. Descriptive, bivariate and multivariable analyses were performed to assess relationships of school location and urinary PAH metabolites with cardiovascular measures.
   Results: Total suspended matter was significantly higher (444 +/- 143 mu g/m(3)) at the school near the refinery compared to a school located near a ring road (395 +/- 65 mu g/m(3)) and a school located away from vehicle traffic (232 +/- 137 mu g/m(3)), as were PAHs. Systolic (0.47 SD units, p=0.006) and diastolic (0.53 SD units, p < 0.001) BP Z-scores were highest at the school near the refinery, with a 4.36-fold increase in prehypertension (p=0.001), controlling for confounders. No differences in pulse pressure, BAD and heart rate were noted in relationship to school location. Urinary total hydroxyphenanthrenes and 1-hydroxypyrene were not associated with cardiovascular outcomes.
   Conclusions: Proximity to an oil refinery in Saudi Arabia is associated with prehypertension and increases in PAH and particulate matter exposures. Further study including insulin resistance measurements, better control for confounding, and longitudinal measurement is indicated. (C) 2014 Elsevier Inc. All rights reserved.
C1 [Trasande, Leonardo] NYU, Sch Med, Dept Pediat, New York, NY USA.
   [Trasande, Leonardo] NYU, Sch Med, New York, NY USA.
   [Trasande, Leonardo] NYU, Wagner Sch Publ Serv, New York, NY USA.
   [Trasande, Leonardo] NYU, Steinhardt Sch Culture Educ & Human Dev, Dept Nutr Food & Publ Hlth, New York, NY USA.
   [Trasande, Leonardo] NYU, Global Inst Publ Hlth, New York, NY USA.
   [Urbina, Elaine M.] Cincinnati Childrens Hosp Med Ctr, Div Prevent Cardiol, Cincinnati, OH 45229 USA.
   [Khoder, Mamdouh.; Alghamdi, Mansour; Shabaj, Ibrahim; Harrison, Roy M.; Shamy, Magdy] King Abdulaziz Univ, Fac Meteorol Environm & Arid Land Agr, Dept Environm Sci, Jeddah 21413, Saudi Arabia.
   [Alam, Mohammed S.; Harrison, Roy M.] Univ Birmingham, Sch Geog Earth & Environm Sci, Div Environm Hlth & Risk Management, Birmingham B15 27T, W Midlands, England.
   [Harrison, Roy M.] King Abdulaziz Univ, Ctr Excellence Environm Studies, Jeddah 21413, Saudi Arabia.
C3 New York University; New York University; New York University; New York
   University; New York University; Cincinnati Children's Hospital Medical
   Center; King Abdulaziz University; University of Birmingham; King
   Abdulaziz University
RP Trasande, L (corresponding author), New York Univ, 227 East 30 St Rm 109, New York, NY 10016 USA.
EM Leonardo.trasande@nyumc.org
RI Trasande, Leonardo/ABE-6339-2020; Alam, Mohammed/N-6508-2015; Harrison,
   Roy/A-2256-2008; Alghamdi, Mansour/B-7085-2014; Khoder,
   Mamdouh/I-7583-2012
OI Alghamdi, Mansour/0000-0001-7518-659X; Trasande,
   Leonardo/0000-0002-1928-597X; Alam, Mohammed Salim/0000-0002-5427-3122;
   Khoder, Mamdouh/0000-0001-8867-1295
FU Deanship of Scientific Research (DSR); King Abdulaziz University (KAU),
   Jeddah, Saudi Arabia [3-10-1432/ HiCi]; DSR; NERC [NE/F016581/1] Funding
   Source: UKRI
FX This study was funded by the Deanship of Scientific Research (DSR), King
   Abdulaziz University (KAU), Jeddah, Saudi Arabia, under Grant no.
   (3-10-1432/ HiCi). The authors, therefore, acknowledge with thanks DSR
   technical and financial support.
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NR 64
TC 48
Z9 54
U1 2
U2 55
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0013-9351
EI 1096-0953
J9 ENVIRON RES
JI Environ. Res.
PD JAN
PY 2015
VL 136
BP 133
EP 140
DI 10.1016/j.envres.2014.08.038
PG 8
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA AX2DY
UT WOS:000346755000017
PM 25460629
OA Green Submitted, Green Accepted
DA 2025-06-11
ER

PT J
AU Mohamed, IN
   Hafez, SS
   Fairaq, A
   Ergul, A
   Imig, JD
   El-Remessy, AB
AF Mohamed, Islam N.
   Hafez, Sherif S.
   Fairaq, Arwa
   Ergul, Adviye
   Imig, John D.
   El-Remessy, Azza B.
TI Thioredoxin-interacting protein is required for endothelial NLRP3
   inflammasome activation and cell death in a rat model of high-fat diet
SO DIABETOLOGIA
LA English
DT Article
DE Caspase-1; High-fat diet; Hypertension; IL-1 beta; Inflammasome;
   Inflammation; NLRP3; Obesity; Oxidative stress; Retinal acellular
   capillaries; TXNIP
ID RETINAL MICROVASCULAR SIGNS; OXIDATIVE STRESS; INSULIN-RESISTANCE;
   METABOLIC SYNDROME; INDUCED OBESITY; ADIPOSE-TISSUE; RISK-FACTORS;
   TXNIP; DYSFUNCTION; RETINOPATHY
AB Obesity and hypertension, known pro-inflammatory states, are identified determinants for increased retinal microvascular abnormalities. However, the molecular link between inflammation and microvascular degeneration remains elusive. Thioredoxin-interacting protein (TXNIP) is recognised as an activator of the NOD-like receptor pyrin domain containing-3 (NLRP3) inflammasome. This study aims to examine TXNIP expression and elucidate its role in endothelial inflammasome activation and retinal lesions.
   Spontaneously hypertensive (SHR) and control Wistar (W) rats were compared with groups fed a high-fat diet (HFD) (W+F and SHR+F) for 8-10 weeks.
   Compared with W controls, HFD alone or in combination with hypertension significantly induced formation of acellular capillaries, a hallmark of retinal ischaemic lesions. These effects were accompanied by significant increases in lipid peroxidation, nitrotyrosine and expression of TXNIP, nuclear factor kappa B, TNF-alpha and IL-1 beta. HFD significantly increased interaction of TXNIP-NLRP3 and expression of cleaved caspase-1 and cleaved IL-1 beta. Immunolocalisation studies identified TXNIP expression within astrocytes and Muller cells surrounding retinal endothelial cells. To model HFD in vitro, human retinal endothelial (HRE) cells were stimulated with 400 mu mol/l palmitate coupled to BSA (Pal-BSA). Pal-BSA triggered expression of TXNIP and its interaction with NLRP3, resulting in activation of caspase-1 and IL-1 beta in HRE cells. Silencing Txnip expression in HRE cells abolished Pal-BSA-mediated cleaved IL-1 beta release into medium and cell death, evident by decreases in cleaved caspase-3 expression and the proportion of live to dead cells.
   These findings provide the first evidence for enhanced TXNIP expression in hypertension and HFD-induced retinal oxidative/inflammatory response and suggest that TXNIP is required for HFD-mediated activation of the NLRP3 inflammasome and the release of IL-1 beta in endothelial cells.
C1 [Mohamed, Islam N.; Hafez, Sherif S.; Fairaq, Arwa; Ergul, Adviye; El-Remessy, Azza B.] Univ Georgia, Coll Pharm, Program Clin & Expt Therapeut, Augusta, GA 30912 USA.
   [Mohamed, Islam N.; El-Remessy, Azza B.] Georgia Reagents Univ, Culver Vis Discovery Inst, Augusta, GA USA.
   [Mohamed, Islam N.; Hafez, Sherif S.; Fairaq, Arwa; Ergul, Adviye; El-Remessy, Azza B.] Charlie Norwood Vet Affairs Med Ctr, Augusta, GA USA.
   [Ergul, Adviye] Georgia Reagents Univ, Dept Physiol, Augusta, GA USA.
   [Imig, John D.] Med Coll Wisconsin, Dept Pharmacol & Toxicol, Milwaukee, WI 53226 USA.
C3 University System of Georgia; University of Georgia; University System
   of Georgia; Augusta University; US Department of Veterans Affairs;
   Veterans Health Administration (VHA); Charlie Norwood VA Medical Center;
   University System of Georgia; Augusta University; Medical College of
   Wisconsin
RP El-Remessy, AB (corresponding author), Univ Georgia, Coll Pharm, Program Clin & Expt Therapeut, 1120 15th St,HM-1200, Augusta, GA 30912 USA.
EM aelremessy@gru.edu
RI El-Remessy, Azza/AAA-3771-2020; Mohamed, Islam/Q-2529-2016
OI Mohamed, Islam/0000-0003-3356-4681; El-Remessy,
   Azza/0000-0003-4386-1989; Imig, John/0000-0002-9668-2899
FU JDRF [4-2008-149]; Vision Discovery Institute [HL59699]; VA Merit Award
   [BX00347, NS054688]; American Heart Association [12PRE10820002]; 
   [EY-022408]; American Heart Association (AHA) [12PRE10820002] Funding
   Source: American Heart Association (AHA)
FX This work was supported in part by grants from EY-022408, JDRF
   (4-2008-149) and Vision Discovery Institute to ABE, HL59699 to JDI, VA
   Merit Award BX00347 and NS054688 to AE and an American Heart Association
   pre-doctoral fellowship (12PRE10820002) for INM.
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NR 50
TC 132
Z9 147
U1 0
U2 23
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0012-186X
EI 1432-0428
J9 DIABETOLOGIA
JI Diabetologia
PD FEB
PY 2014
VL 57
IS 2
BP 413
EP 423
DI 10.1007/s00125-013-3101-z
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 288MC
UT WOS:000329615100019
PM 24201577
OA Bronze, Green Accepted
DA 2025-06-11
ER

PT J
AU Karelis, AD
   Fontaine, J
   Messier, V
   Messier, L
   Blanchard, C
   Rabasa-Lhoret, R
   Strychar, I
AF Karelis, Antony D.
   Fontaine, Jonathan
   Messier, Virginie
   Messier, Lyne
   Blanchard, Chris
   Rabasa-Lhoret, Remi
   Strychar, Irene
TI Psychosocial correlates of cardiorespiratory fitness and muscle strength
   in overweight and obese post-menopausal women: A MONET study
SO JOURNAL OF SPORTS SCIENCES
LA English
DT Article
DE quality of life; body esteem; perceived stress; self-esteem; perceived
   risk
ID PHYSICAL-ACTIVITY; METABOLIC SYNDROME; HEALTHY-MEN; ADOLESCENTS;
   MORTALITY; ASSOCIATION; PREDICTORS; ADULTS; RISK
AB The purpose of this study was to examine the psychosocial correlates of cardiorespiratory fitness ((V) over dotO(2peak)) and muscle strength in overweight and obese sedentary post-menopausal women. The study population consisted of 137 non-diabetic, sedentary overweight and obese post-menopausal women (mean age 57.7years, s=4.8; body mass index 32.4kg.m(-2), s=4.6). At baseline we measured: (1) body composition using dual-energy X-ray absorptiometry; (2) visceral fat using computed tomography; (3) insulin sensitivity using the hyperinsulinaemic-euglycaemic clamp; (4) cardiorespiratory fitness; (5) muscle strength using the leg press exercise; and (6) psychosocial profile (quality of life, perceived stress, self-esteem, body-esteem, and perceived risk for developing chronic diseases) using validated questionnaires. Both(V) over dotO(2peak) and muscle strength were significantly correlated with quality of life (r=0.29, P < 0.01 and r=0.30, P < 0.01, respectively), and quality of life subscales for: physical functioning (r=0.28, P < 0.01 and r=0.22, P < 0.05, respectively), pain (r=0.18, P < 0.05 and r=0.23, P < 0.05, respectively), role functioning (r=0.20, P < 0.05 and r=0.24, P < 0.05, respectively), and perceived risks (r=-0.24, P < 0.01 and r=-0.30, P < 0.01, respectively). In addition, [Vdot]O2(peak) was significantly associated with positive health perceptions, greater body esteem, and less time watching television/video. Stepwise regression analysis showed that quality of life for health perceptions and for role functioning were independent predictors of (V) over dotO(2peak) and muscle strength, respectively. In conclusion, higher (V) over dotO(2peak) and muscle strength are associated with a favourable psychosocial profile, and the psychosocial correlates of (V) over dotO(2peak) were different from those of muscle strength. Furthermore, psychosocial factors could be predictors of (V) over dotO(2peak) and muscle strength in our cohort of overweight and obese sedentary post-menopausal women.
C1 [Karelis, Antony D.] Univ Quebec, Dept Kinanthropol, Montreal, PQ H2X 3R9, Canada.
   [Fontaine, Jonathan; Messier, Virginie; Messier, Lyne; Rabasa-Lhoret, Remi; Strychar, Irene] Univ Montreal, Dept Nutr, Montreal, PQ H3C 3J7, Canada.
   [Blanchard, Chris] Univ Ottawa, Fac Hlth Sci, Sch Human Kinet, Ottawa, ON, Canada.
C3 University of Quebec; University of Quebec Montreal; Universite de
   Montreal; University of Ottawa
RP Karelis, AD (corresponding author), Univ Quebec, Dept Kinanthropol, 1205 St Denis, Montreal, PQ H2X 3R9, Canada.
EM karelis.antony@uqam.ca
RI Blanchard, Christopher/P-5124-2016
CR [Anonymous], 1989, SOC ADOLESCENT SELF
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NR 24
TC 16
Z9 17
U1 0
U2 4
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 0264-0414
J9 J SPORT SCI
JI J. Sports Sci.
PY 2008
VL 26
IS 9
BP 935
EP 940
DI 10.1080/02640410801885958
PG 6
WC Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Sport Sciences
GA 318JN
UT WOS:000257087500007
PM 18569559
DA 2025-06-11
ER

PT J
AU Gresl, TA
   Colman, RJ
   Roecker, EB
   Havighurst, TC
   Huang, Z
   Allison, DB
   Bergman, RN
   Kemnitz, JW
AF Gresl, TA
   Colman, RJ
   Roecker, EB
   Havighurst, TC
   Huang, Z
   Allison, DB
   Bergman, RN
   Kemnitz, JW
TI Dietary restriction and glucose regulation in aging rhesus monkeys: a
   follow-up report at 8.5 yr
SO AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
LA English
DT Article
DE glucose metabolism; insulin; minimal model; energy restriction
ID DEPENDENT DIABETES-MELLITUS; BODY-FAT DISTRIBUTION; INSULIN SENSITIVITY
   INDEX; CALORIC RESTRICTION; ADULT MALE; ENERGY RESTRICTION; OXIDATIVE
   STRESS; WEIGHT-LOSS; SYNDROME-X; OBESITY
AB In a longitudinal study of the effects of moderate (70%) dietary restriction (DR) on aging, plasma glucose and insulin concentrations were measured from semiannual, frequently sampled intravenous glucose tolerance tests (FSIGTT) in 30 adult male rhesus monkeys. FSIGTT data were analyzed with Bergman's minimal model, and analysis of covariance revealed that restricted (R) monkeys exhibited increased insulin sensitivity (S-I, P < 0.001) and plasma glucose disappearance rate (K-G, P = 0.015), and reduced fasting plasma insulin (I-b, P < 0.001) and insulin response to glucose (AIR(G), P = 0.023) compared with control (C; ad libitum-fed) monkeys. DR reduced the baseline fasting hyperinsulinemia of two R monkeys, whereas four C monkeys have maintained from baseline, or subsequently developed, fasting hyperinsulinemia; one has progressed to diabetes. Compared with only the normoinsulinemic C monkeys, R monkeys exhibited similarly improved FSIGTT and minimal-model parameters. Thus chronic DR not only has protected against the development of insulin resistance in aging rhesus monkeys, but has also improved glucoregulatory parameters compared with those of otherwise normoinsulinemic monkeys.
C1 Univ Wisconsin, Wisconsin Reg Primate Res Ctr, Madison, WI 53715 USA.
   Univ Wisconsin, Dept Nutr Sci, Madison, WI 53706 USA.
   Univ Wisconsin, Dept Biostat & Med Informat, Madison, WI 53706 USA.
   Univ Wisconsin, Dept Physiol, Madison, WI 53706 USA.
   Vet Adm Geriatr Res Educ & Clin Ctr, Madison, WI 53715 USA.
   Columbia Univ, Coll Phys & Surg, Obes Res Ctr, New York, NY 10025 USA.
   Univ So Calif, Dept Physiol & Biophys, Los Angeles, CA 90033 USA.
C3 University of Wisconsin System; University of Wisconsin Madison;
   University of Wisconsin System; University of Wisconsin Madison;
   University of Wisconsin System; University of Wisconsin Madison;
   University of Wisconsin System; University of Wisconsin Madison;
   Geriatric Research Education & Clinical Center; Columbia University;
   University of Southern California
RP Kemnitz, JW (corresponding author), Univ Wisconsin, Wisconsin Reg Primate Res Ctr, 1220 Capitol Court, Madison, WI 53715 USA.
RI Bergman, Richard/B-9894-2013; Kemnitz, Joseph/ABA-4668-2020
OI Bergman, Richard/0000-0003-1539-4471; Allison,
   David/0000-0003-3566-9399; Kemnitz, Joseph W/0000-0001-6511-404X;
   Colman, Ricki/0000-0001-9706-0525
FU NCRR NIH HHS [P51-RR-00167] Funding Source: Medline; NIA NIH HHS
   [P01-AG-11915, R01-AG-07831] Funding Source: Medline
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   [No title captured]
NR 43
TC 74
Z9 79
U1 0
U2 3
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0193-1849
J9 AM J PHYSIOL-ENDOC M
JI Am. J. Physiol.-Endocrinol. Metab.
PD OCT
PY 2001
VL 281
IS 4
BP E757
EP E765
DI 10.1152/ajpendo.2001.281.4.E757
PG 9
WC Endocrinology & Metabolism; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Physiology
GA 482NY
UT WOS:000171583200014
PM 11551852
DA 2025-06-11
ER

PT J
AU Sanderson, JE
   Haines, CJ
   Yeung, L
   Yip, GWK
   Tang, K
   Yim, SF
   Jorgensen, LN
   Woo, J
AF Sanderson, JE
   Haines, CJ
   Yeung, L
   Yip, GWK
   Tang, K
   Yim, SF
   Jorgensen, LN
   Woo, J
TI Anti-ischemic action of estrogen-progestogen continuous combined hormone
   replacement therapy in postmenopausal women with established angina
   pectoris: A randomized, placebo-controlled, double-blind, parallel-group
   trial
SO JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
LA English
DT Article
DE postmenopausal; estrogen-progestogen; continuous combined; hormone
   replacement therapy; coronary heart disease
ID CORONARY-ARTERY DISEASE; ACUTE MYOCARDIAL-INFARCTION; HEART-DISEASE;
   PLASMA-LIPOPROTEINS; SYNDROME-X; 17-BETA-ESTRADIOL; RISK;
   NORETHISTERONE; VASODILATION; METABOLISM
AB The benefit of treating postmenopausal women with established cardiovascular disease with combined estrogen-progestogen hormone replacement therapy (HRT) is controversial. This study investigated the effect of treatment with estradiol and norethisterone acetate on exercise tolerance and on the frequency and severity of ischemic attacks in postmenopausal women with stable angina pectoris. A total of 74 Chinese women were recruited for this 16-week double-blind. placebo-controlled trial. They were randomly allocated into two groups one group received placebo/placebo/placebo and the other group received placebo/estrogen-progestogen/placebo. Estrogen-progestogen continuous combined HRT increased both time to I-mm ST depression (99.1 s, p < 0.05) compared with a mean decrease of 22.9 s with placebo (p < 0.05), and total exercise duration also showed a significant increase (32.7 s, p < 0.05) after treatment compared with placebo (2.5 s, p < 0.05). In addition. the total number of ischemic events/24 h during ambulatory electrocardiographic monitoring decreased by 0.82 events after treatment (p < 0.05) compared with an increase in the placebo group (0.94). a highly significant difference (p = 0.006). These results suggest that the administration of this particular combined hormone replacement preparation may have a beneficial effect on myocardial ischemia in postmenopausal women with established coronary disease.
C1 Chinese Univ Hong Kong, Dept Med & Therapeut, Hong Kong, Hong Kong, Peoples R China.
   Chinese Univ Hong Kong, Dept Obstet & Gynaecol, Hong Kong, Hong Kong, Peoples R China.
   Novo Nordisk AS, Singapore, Singapore.
C3 Chinese University of Hong Kong; Chinese University of Hong Kong; Novo
   Nordisk
RP Sanderson, JE (corresponding author), Chinese Univ Hong Kong, Prince Wales Hosp, Dept Med & Therapeut, Hong Kong, Hong Kong, Peoples R China.
RI Yip, Gabriel/A-8837-2008; Woo, Jean/K-2625-2014
OI Yip, Gabriel/0000-0002-3859-7194; Woo, Jean/0000-0001-7593-3081
CR Albertsson PA, 1996, INT J CARDIOL, V54, P13, DOI 10.1016/0167-5273(96)02560-0
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NR 36
TC 11
Z9 11
U1 0
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0160-2446
J9 J CARDIOVASC PHARM
JI J. Cardiovasc. Pharmacol.
PD SEP
PY 2001
VL 38
IS 3
BP 372
EP 383
DI 10.1097/00005344-200109000-00006
PG 12
WC Cardiac & Cardiovascular Systems; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Pharmacology & Pharmacy
GA 463JW
UT WOS:000170474100006
PM 11486242
OA Bronze
DA 2025-06-11
ER

PT J
AU Bashandy, SAE
   El-Seidy, AMA
   Ibrahim, FAA
   Abdelrahman, SS
   Moussa, SAA
   ElBaset, MA
AF Bashandy, Samir A. E.
   El-Seidy, Ahmed M. A.
   Ibrahim, Fatma A. A.
   Abdelrahman, Sahar S.
   Moussa, Sherif A. Abdelmottaleb
   ElBaset, Marawan A.
TI Zinc nanoparticles ameliorated obesity-induced cardiovascular disease:
   role of metabolic syndrome and iron overload
SO SCIENTIFIC REPORTS
LA English
DT Article
ID OXIDATIVE STRESS; LIPID-METABOLISM; INFLAMMATION; PROTEIN; SILVER;
   INCREASES; HEPCIDIN
AB Obesity is a complicated disease characterized by abundant fat accumulation. It is associated with cardiovascular disease. The current study aimed to appreciate the role of synthesized zinc oxide nanoparticles (ZnONPs) (18.72 nm in size) in curbing cardiovascular disease in an obesity model of a high fat/sucrose diet in male rats. For 16 weeks, 24 rats were fed a high-fat diet and a 25% sucrose solution to develop obesity, and after that, the rats were randomly allocated into four groups of rats. Group 1 served as the control group and consisted of normal, non-obese rats. Group 2 comprised obese rats that were injected with an equivalent volume of a neutral substance, serving as vehicle control. In Group 3 or 4, obese rats were treated with an intraperitoneal injection of 5 or 10mg/kg of zinc oxide nanoparticles (ZnONPs) for eight weeks. The treatment of obese rats with ZnONPs decreased plasma levels of monocyte chemoattractant Protein-1 (MCP-1), resistin, ENA78, tumor necrosis factor-alpha (TNF-alpha), interleukin 6 (IL6), and C reactive protein (CRP). Also, the remediation of obese rats with ZnONPs led to a significant decrease in body mass index (BMI), body weight gain, leptin, cholesterol, triglycerides, LDL (Low-density lipoprotein), glucose, and insulin resistance index (HOMA-IR). Moreover, ZnONPs treatment lowered troponin, creatine phosphokinase-MB (CK-MB), lactate dehydrogenase (LDH), cardiac or adipose tissue iron content, and malondialdehyde (MDA) either in blood or heart tissue. Otherwise, treating obese rats with ZnONPs enhanced plasma adiponectin levels, cardiac-reduced glutathione (GSH), and superoxide dismutase (SOD). In addition, ZnONPs displayed a significant influence on the cardiovascular system since they combat the rise in blood pressure and the pathological changes of the heart and aorta besides maintaining plasma nitric oxide levels. The results showed a positive correlation between BMI and MDA, MPC-1, CK-MB, and LDH. ZnONPs are convenient in treating cardiovascular disease in obese rats via reduced blood pressure, oxidative stress, cardiac iron accumulation, insulin resistance, and inflammatory markers.
C1 [Bashandy, Samir A. E.; ElBaset, Marawan A.] Natl Res Ctr, Pharmacol Dept, 33 El Bohouth St,PO 12622, Cairo, Egypt.
   [El-Seidy, Ahmed M. A.; Moussa, Sherif A. Abdelmottaleb] Natl Res Ctr, Inorgan Chem Dept, 33 El Bohouth St,PO 12622, Cairo, Egypt.
   [Ibrahim, Fatma A. A.] Natl Res Ctr, Dept Biochem, Biophys Grp, 33 El Bohouth St,PO 12622, Cairo, Egypt.
   [Abdelrahman, Sahar S.] Cairo Univ, Pathol Dept, Fac Vet Med, Cairo, Egypt.
C3 Egyptian Knowledge Bank (EKB); National Research Centre (NRC); Egyptian
   Knowledge Bank (EKB); National Research Centre (NRC); Egyptian Knowledge
   Bank (EKB); National Research Centre (NRC); Egyptian Knowledge Bank
   (EKB); Cairo University
RP ElBaset, MA (corresponding author), Natl Res Ctr, Pharmacol Dept, 33 El Bohouth St,PO 12622, Cairo, Egypt.
EM dr.marawan@gmail.com
RI El-Seidy, Ahmed/ABH-3277-2021; Sayed, Marawan/M-8214-2019
OI Sayed, Marawan/0000-0002-0861-6251; El-Seidy, Ahmed/0000-0003-0708-7658
FU National Research Centre, Cairo, Egypt [12060157]
FX This work is financially supported by National Research Centre, Cairo,
   Egypt (Project No 12060157). The authors would like to thank Science
   Shake Inc. for conducting proofreading and English language editing
   (https://www.science-shake.com/).
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NR 78
TC 17
Z9 17
U1 1
U2 2
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD SEP 25
PY 2023
VL 13
IS 1
AR 16010
DI 10.1038/s41598-023-42550-y
PG 19
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA AD6I3
UT WOS:001116558400021
PM 37749096
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Huettl, M
   Markova, I
   Miklankova, D
   Zapletalova, I
   Kujal, P
   Silhavy, J
   Pravenec, M
   Malinska, H
AF Huettl, Martina
   Markova, Irena
   Miklankova, Denisa
   Zapletalova, Iveta
   Kujal, Petr
   Silhavy, Jan
   Pravenec, Michal
   Malinska, Hana
TI Hypolipidemic and insulin sensitizing effects of salsalate beyond
   suppressing inflammation in a prediabetic rat model
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Article
DE salsalate; low-grade inflammation; prediabetes; lipid metabolism;
   cytochrome P450; oxidative stress
ID CARDIOVASCULAR-DISEASE; RISK-FACTORS; RESISTANCE; SALICYLATE; ASPIRIN;
   LIVER; GLYCATION; TRIAL
AB Background and aims: Low-grade chronic inflammation plays an important role in the pathogenesis of metabolic syndrome, type 2 diabetes and their complications. In this study, we investigated the effects of salsalate, a non-steroidal anti-inflammatory drug, on metabolic disturbances in an animal model of prediabetes-a strain of non-obese hereditary hypertriglyceridemic (HHTg) rats.Materials and Methods: Adult male HHTg and Wistar control rats were fed a standard diet without or with salsalate delivering a daily dose of 200 mg/kg of body weight for 6 weeks. Tissue sensitivity to insulin action was measured ex vivo according to basal and insulin-stimulated C-14-U-glucose incorporation into muscle glycogen or adipose tissue lipids. The concentration of methylglyoxal and glutathione was determined using the HPLC-method. Gene expression was measured by quantitative RT-PCR.Results: Salsalate treatment of HHTg rats when compared to their untreated controls was associated with significant amelioration of inflammation, dyslipidemia and insulin resistance. Specificaly, salsalate treatment was associated with reduced inflammation, oxidative and dicarbonyl stress when inflammatory markers, lipoperoxidation products and methylglyoxal levels were significantly decreased in serum and tissues. In addition, salsalate ameliorated glycaemia and reduced serum lipid concentrations. Insulin sensitivity in visceral adipose tissue and skeletal muscle was significantly increased after salsalate administration. Further, salsalate markedly reduced hepatic lipid accumulation (triglycerides -29% and cholesterol -14%). Hypolipidemic effects of salsalate were associated with differential expression of genes coding for enzymes and transcription factors involved in lipid synthesis (Fas, Hmgcr), oxidation (Ppara) and transport (Ldlr, Abc transporters), as well as changes in gene expression of cytochrome P450 proteins, in particular decreased Cyp7a and increased Cyp4a isoforms.Conclusion: These results demonstrate important anti-inflammatory and anti-oxidative effects of salsalate that were associated with reduced dyslipidemia and insulin resistance in HHTg rats. Hypolipidemic effects of salsalate were associated with differential expression of genes regulating lipid metabolism in the liver. These results suggest potential beneficial use of salsalate in prediabetic patients with NAFLD symptoms.
C1 [Huettl, Martina; Markova, Irena; Miklankova, Denisa; Malinska, Hana] Inst Clin & Expt Med, Ctr Expt Med, Prague, Czech Republic.
   [Zapletalova, Iveta] Palacky Univ, Fac Med & Dent, Dept Pharmacol, Olomouc, Czech Republic.
   [Kujal, Petr] Charles Univ Prague, Fac Med 3, Dept Pathol, Prague, Czech Republic.
   [Silhavy, Jan; Pravenec, Michal] Czech Acad Sci, Inst Physiol, Prague, Czech Republic.
C3 Institute for Clinical & Experimental Medicine (IKEM); Palacky
   University Olomouc; Charles University Prague; Czech Academy of
   Sciences; Institute of Physiology of the Czech Academy of Sciences
RP Malinska, H (corresponding author), Inst Clin & Expt Med, Ctr Expt Med, Prague, Czech Republic.
EM hana.malinska@ikem.cz
RI Silhavy, Jan/B-5292-2014; Zapletalova, Iveta/AAA-2142-2022
OI Zapletalova, Iveta/0000-0003-0869-8848
FU project National Institute for Research of Metabolic and Cardiovascular
   Diseases-Program EXCELES - European Union-Next-Generation EU
   [LX22NPO5104]; Ministry of Health of the Czech Republic
   [IGA_LF_2023_004]
FX This work was supported by the project National Institute for Research
   of Metabolic and Cardiovascular Diseases-Program EXCELES, Project No.
   LX22NPO5104-funded by the European Union-Next-Generation EU and by a
   grant from Ministry of Health of the Czech Republic no. IGA_LF_2023_004.
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NR 38
TC 10
Z9 10
U1 2
U2 7
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD APR 3
PY 2023
VL 14
AR 1117683
DI 10.3389/fphar.2023.1117683
PG 11
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA E1DN3
UT WOS:000973027300001
PM 37077818
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Shin, MJ
   Lee, JH
   Jang, Y
   Park, E
   Oh, J
   Chung, JH
   Chung, N
AF Shin, Min-Jeong
   Lee, Jong Ho
   Jang, Yangsoo
   Park, Eunju
   Oh, Jaewon
   Chung, Ji Hyung
   Chung, Namsik
TI Insulin resistance, adipokines, and oxidative stress in nondiabetic,
   hypercholesterolemic patients:: leptin as an 8-epi-prostaglandin
   F2α determinant
SO METABOLISM-CLINICAL AND EXPERIMENTAL
LA English
DT Article
ID METABOLIC SYNDROME; SERUM RESISTIN; ADIPONECTIN; OBESE; HEALTHY; LDL;
   ISOPROSTANES; ASSOCIATION; VOLUNTEERS; ADIPOSITY
AB Limited data are available on the association of insulin resistance, adipokines, and in vivo lipid peroxidation. We investigated the relationships between insulin resistance, adipokines (leptin, adiponectin, and resistin), and oxidative stress in nondiabetic, hypercholesterolemic patients. Seventy-six nondiabetic patients with hypercholesterolemia participated in this cross-sectional study. Fasting glucose and insulin concentrations were analyzed. Serum leptin, adiponectin, and resistin concentrations and urinary excretion of 8-epi-prostaglandin F-2 alpha (8-ePi-PGF(2 alpha)) were determined using enzyme-linked immunosorbent assay. We divided all subjects into 3 groups, classified by the tertiles of homeostasis model assessment of insulin resistance (HOMA-IR) values, and clinical parameter comparisons were made among the 3 groups. The results showed that serum leptin (P <.001) and adiponectin levels (P <.05) were significantly different among the groups, although serum resistin was not different. Furthermore, the group with the highest HOMA-IR had a significantly higher urinary 8-epi-PGF(2 alpha) excretion than the group with the lowest HOMA-IR (P =.017). Circulating leptin was positively correlated with urinary 8-epi-PGF(2 alpha) (r = 0.323, P <.0 1) and HOMA-IR (r = 0.524, P <.001). Circulating adiponectin was negatively correlated with body mass index (r = -0.252, P <.05) and HOMAIR (r = -0.228, P <.05). We could not find a relationship between circulating adiponectin or resistin and urinary 8-epi-PGF(2 alpha) excretion. Stepwise multiple linear regression analysis showed that leptin was associated with the urinary 8-epi-PGF(2 alpha) excretion after adjusting for age, sex, body mass index, blood lipids, and HOMA-fR (P = 002). In conclusion, our results show that more insulin-resistant state of nondiabetic, hypercholesterolemic patients is associated with decreased adiponectin and increased leptin and urinary 8-epi-PGF(2 alpha) levels, although no relationship with resistin was observed. Furthermore, serum leptin independently contributed to urinary 8-epi-PGF(2 alpha) excretion. (c) 2006 Elsevier Inc. All rights reserved.
C1 Yonsei Univ, Coll Med, Cardiovasc Res Inst, Seoul 120752, South Korea.
   Yonsei Univ, Res Inst Aging Sci, Seoul 120749, South Korea.
   Kyungnam Univ, Dept Food & Nutr, Masan 631701, South Korea.
   Yonsei Univ, Coll Med, Brain Korea Project Med Sci 21, Seoul 120752, South Korea.
C3 Yonsei University; Yonsei University Health System; Yonsei University;
   Kyungnam University; Yonsei University; Yonsei University Health System
RP Chung, N (corresponding author), Yonsei Univ, Coll Med, Cardiovasc Res Inst, Seoul 120752, South Korea.
EM namsikc@yumc.yonsei.ac.kr
RI Chow, Elaine/HJB-2197-2022; Shin, Minjeong/HTT-0324-2023; Park,
   Eunju/AAF-9669-2021; Jang, Yang/D-4803-2012
OI Jang, Yangsoo/0000-0002-2169-3112
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NR 36
TC 21
Z9 22
U1 0
U2 0
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0026-0495
EI 1532-8600
J9 METABOLISM
JI Metab.-Clin. Exp.
PD JUL
PY 2006
VL 55
IS 7
BP 918
EP 922
DI 10.1016/j.metabol.2006.02.020
PG 5
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 058VC
UT WOS:000238691700011
PM 16784964
DA 2025-06-11
ER

PT J
AU Bariya, S
   Tao, Y
   Zhang, RQ
   Zhang, M
AF Bariya, Shrijan
   Tao, Yun
   Zhang, Ruiqing
   Zhang, Ming
TI Impact of sleep characteristics on IVF/ICSI outcomes: A prospective
   cohort study
SO SLEEP MEDICINE
LA English
DT Article
DE Sleep characteristics; Sleep duration; Sleep quality; Daytime napping;
   IVF/ICSI; Perceived stress; Reproductive health
ID IN-VITRO FERTILIZATION; CARDIOVASCULAR-DISEASES; METABOLIC SYNDROME;
   INFERTILE COUPLES; QUALITY INDEX; ASSOCIATION; WOMEN; INSOMNIA; RISK;
   METAANALYSIS
AB Background: Infertility affects millions of individuals worldwide, imposing significant personal and societal burdens. Assisted reproductive technologies (ART), such as IVF and ICSI, provide hope for many, yet clinical pregnancy rate per embryo transfer remains around 35 %. Modifiable lifestyle factors, including sleep, may influence ART outcomes. However, the relationship between specific sleep characteristics and IVF/ICSI success is unclear. This study aims to explore the associations between sleep characteristics and various IVF/ICSI outcomes. Additionally, we investigated if perceived stress mediates these relationships. Methods: This prospective cohort study enrolled 174 women undergoing IVF/ICSI at Zhongnan Hospital of Wuhan University from December 2021 to December 2023. Prior to initial ART treatment, participants completed the Pittsburgh Sleep Quality Index (PSQI) and the Perceived Stress Scale (PSS-10). IVF/ICSI outcomes such as the number of retrieved oocytes, matured oocytes, number of fertilized oocytes, fertilization rate, good-quality embryos, blastocyst formation rate and early pregnancy outcome (implantation and clinical pregnancy) were obtained from medical records. We employed multivariate generalized linear models to assess the associations between sleep characteristics and IVF/ICSI outcomes. Dose-response relationships between napping duration and maturation rate were analyzed using generalized additive models. Mediation analysis was used to assess the role of stress in the relationship between sleep characteristics and IVF/ICSI outcomes. Results: Women reporting poor sleep quality had significantly fewer retrieved oocytes (-22.89 %, 95%CI: 37.82 %, -4.00 %) and matured oocytes (-22.01 %, 95%CI: 37.54 %, -2.62 %). Those sleeping >= 10 h per night had fewer retrieved oocytes (-30.68 %, 95%CI: 48.88 %, -6.00 %), matured oocytes (-27.17 %, 95%CI: 46.57 %, -0.73 %), and good-quality embryos (-45.64 %, 95%CI: 65.43 %, -14.51 %). Women experiencing difficulty falling asleep more than three times a week had a significant reduction in blastocyst rates (-64.40 %, 95 % CI: 85.55 %, -12.30 %). Those reporting difficulty falling asleep less than once a week had fewer retrieved oocytes (-28.89 %, 95%CI: 47.34 %, -3.98 %), and matured oocytes (-27.77 %, 95%CI: 46.90 %, -1.73 %). Napping exceeding 1 h daily was associated with a significantly lower oocyte maturation rate (-73.8 %, 95%CI: 88.91 %, -38.06 %). A significant non-linear dose-response relationship was observed between napping duration and maturation rate (p < 0.001), with maturation rates initially increasing slightly with short naps but declining significantly with longer naps, particularly beyond 1 h. This relationship was significant among women with good sleep quality (PSQI <= 5) (p < 0.001) and those with normal BMI (p = 0.0005). Perceived stress did not significantly mediate these associations. Conclusion: Our findings suggest that sleep characteristics, particularly poor quality, difficulty falling asleep, long sleep durations, negatively impact various IVF/ICSI outcomes. Longer daytime napping is inversely associated with oocyte maturation rates, especially among women with good sleep quality and normal BMI. Perceived stress did not appear to influence the relationship between sleep and IVF outcome. While optimizing sleep patterns may hold promise for improving IVF/ICSI success rates, it is essential to approach lifestyle guidance with caution, given the current limitations in confirming causative roles.
   Further studies are needed to clarify the extent and nature of the relationship between sleep characteristics and IVF/ICSI outcomes.
C1 [Bariya, Shrijan; Zhang, Ruiqing; Zhang, Ming] Wuhan Univ, Zhongnan Hosp, Dept Reprod Med, 169 East Lake Rd, Wuhan 430071, Hubei, Peoples R China.
   [Tao, Yun] Wuhan Univ, Zhongnan Hosp, Dept Obstet & Gynecol, Wuhan, Peoples R China.
   [Bariya, Shrijan; Tao, Yun; Zhang, Ruiqing; Zhang, Ming] Hubei Clin Res Ctr Prenatal Diag & Birth Hlth, Wuhan, Peoples R China.
   [Bariya, Shrijan; Tao, Yun; Zhang, Ruiqing; Zhang, Ming] Wuhan Clin Res Ctr Reprod Sci & Birth Hlth, Wuhan, Peoples R China.
C3 Wuhan University; Wuhan University
RP Zhang, M (corresponding author), Wuhan Univ, Zhongnan Hosp, Dept Reprod Med, 169 East Lake Rd, Wuhan 430071, Hubei, Peoples R China.
EM whu_mz@163.com
FU National Natural Science Foundation of China (NSFC) [82071659]; Basic
   and Clinical Medical Research Joint Fund of Zhongnan Hospital, Wuhan
   University [ZNLH202206]
FX The present study was supported by the National Natural Science
   Foundation of China (NSFC) (No. 82071659 to M.Z.) and the Basic and
   Clinical Medical Research Joint Fund of Zhongnan Hospital, Wuhan
   University (No. ZNLH202206 to M.Z.) .
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NR 113
TC 0
Z9 0
U1 3
U2 3
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1389-9457
EI 1878-5506
J9 SLEEP MED
JI Sleep Med.
PD FEB
PY 2025
VL 126
BP 122
EP 135
DI 10.1016/j.sleep.2024.11.038
EA DEC 2024
PG 14
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA U7L2V
UT WOS:001413556700001
PM 39672092
DA 2025-06-11
ER

PT J
AU Grieger, JA
   Bianco-Miotto, T
   Grzeskowiak, LE
   Leemaqz, SY
   Poston, L
   McCowan, LM
   Kenny, LC
   Myers, JE
   Walker, JJ
   Dekker, GA
   Roberts, CT
AF Grieger, Jessica A.
   Bianco-Miotto, Tina
   Grzeskowiak, Luke E.
   Leemaqz, Shalem Y.
   Poston, Lucilla
   McCowan, Lesley M.
   Kenny, Louise C.
   Myers, Jenny E.
   Walker, James J.
   Dekker, Gus A.
   Roberts, Claire T.
TI Metabolic syndrome in pregnancy and risk for adverse pregnancy outcomes:
   A prospective cohort of nulliparous women
SO PLOS MEDICINE
LA English
DT Article
ID GESTATIONAL DIABETES-MELLITUS; BODY-MASS INDEX; RECURRENT PREECLAMPSIA;
   INSULIN-RESISTANCE; MATERNAL OBESITY; BIRTH; DISEASE; HEALTH; DIAGNOSIS;
   GLUCOSE
AB Background
   Obesity increases the risk for developing gestational diabetes mellitus (GDM) and preeclampsia (PE), which both associate with increased risk for type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD) in women in later life. In the general population, metabolic syndrome (MetS) associates with T2DM and CVD. The impact of maternal MetS on pregnancy outcomes, in nulliparous pregnant women, has not been investigated.
   Methods and findings
   Low-risk, nulliparous women were recruited to the multi-centre, international prospective Screening for Pregnancy Endpoints (SCOPE) cohort between 11 November 2004 and 28 February 2011. Women were assessed for a range of demographic, lifestyle, and metabolic health variables at 15 +/- 1 weeks' gestation. MetS was defined according to International Diabetes Federation (IDF) criteria for adults: waist circumference >= 80 cm, along with any 2 of the following: raised trigycerides (>= 1.70 mmol/l [< 150 mg/dl]), reduced high-density lipoprotein cholesterol (<1.29 mmol/l [<50 mg/dl]), raised blood pressure (BP) (i.e., systolic BP >= 130 mm Hg or diastolic BP >= 85 mm Hg), or raised plasma glucose (>= 5.6 mmol/l). Logbinomial regression analyses were used to examine the risk for each pregnancy outcome (GDM, PE, large for gestational age [LGA], small for gestational age [SGA], and spontaneous preterm birth [sPTB]) with each of the 5 individual components for MetS and as a composite measure (i.e., MetS, as defined by the IDF). The relative risks, adjusted for maternal BMI, age, study centre, ethnicity, socioeconomic index, physical activity, smoking status, depression status, and fetal sex, are reported. A total of 5,530 women were included, and 12.3% (n = 684) had MetS. Women with MetS were at an increased risk for PE by a factor of 1.63 (95% CI 1.23 to 2.15) and for GDM by 3.71 (95% CI 2.42 to 5.67). In absolute terms, for PE, women with MetS had an adjusted excess risk of 2.52% (95% CI 1.51% to 4.11%) and, for GDM, had an adjusted excess risk of 8.66% (95% CI 5.38% to 13.94%). Diagnosis of MetS was not associated with increased risk for LGA, SGA, or sPTB. Increasing BMI in combination with MetS increased the estimated probability for GDM and decreased the probability of an uncomplicated pregnancy. Limitations of this study are that there are several different definitions for MetS in the adult population, and as there are none for pregnancy, we cannot be sure that the IDF criteria are the most appropriate definition for pregnancy. Furthermore, MetS was assessed in the first trimester and may not reflect prepregnancy metabolic health status.
   Conclusions
   We did not compare the impact of individual metabolic components with that of MetS as a composite, and therefore cannot conclude that MetS is better at identifying women at risk. However, more than half of the women who had MetS in early pregnancy developed a pregnancy complication compared with just over a third of women who did not have MetS. Furthermore, while increasing BMI increases the probability of GDM, the addition of MetS exacerbates this probability. Further studies are required to determine if individual MetS components act synergistically or independently.
C1 [Grieger, Jessica A.; Bianco-Miotto, Tina; Grzeskowiak, Luke E.; Leemaqz, Shalem Y.; Dekker, Gus A.; Roberts, Claire T.] Univ Adelaide, Robinson Res Inst, Adelaide, SA, Australia.
   [Grieger, Jessica A.; Grzeskowiak, Luke E.; Leemaqz, Shalem Y.; Dekker, Gus A.; Roberts, Claire T.] Univ Adelaide, Adelaide Med Sch, Adelaide, SA, Australia.
   [Bianco-Miotto, Tina] Univ Adelaide, Waite Res Inst, Sch Agr Food & Wine, Adelaide, SA, Australia.
   [Poston, Lucilla] Kings Coll London, St Thomas Hosp, Dept Women & Childrens Hlth, London, England.
   [McCowan, Lesley M.] Univ Auckland, Dept Obstet & Gynaecol, Auckland, New Zealand.
   [Kenny, Louise C.] Univ Liverpool, Fac Hlth & Life Sci, Liverpool, Merseyside, England.
   [Myers, Jenny E.] Univ Manchester, Maternal & Fetal Hlth Res Ctr, Manchester, Lancs, England.
   [Walker, James J.] Univ Leeds, Leeds Inst Biomed & Clin Sci, Obstet & Gynaecol Sect, Leeds, W Yorkshire, England.
   [Dekker, Gus A.] Lyell McEwin Hosp, Women & Childrens Div, Adelaide, SA, Australia.
C3 Robinson Research Institute; University of Adelaide; University of
   Adelaide; University of Adelaide; University of London; King's College
   London; Guy's & St Thomas' NHS Foundation Trust; University of Auckland;
   University of Liverpool; University of Manchester; University of Leeds;
   Lyell McEwin Hospital
RP Roberts, CT (corresponding author), Univ Adelaide, Robinson Res Inst, Adelaide, SA, Australia.; Roberts, CT (corresponding author), Univ Adelaide, Adelaide Med Sch, Adelaide, SA, Australia.
EM claire.roberts@adelaide.edu.au
RI Walker, James/IXN-1454-2023; Kenny, Louise/X-6329-2019; McCowan,
   Lesley/C-2215-2009; Grieger, Jessica/V-4474-2019; Roberts,
   Claire/A-1205-2007; Grzeskowiak, Luke/H-3885-2016; Bianco-Miotto,
   Tina/C-4808-2008; Kenny, Louise/G-1112-2011
OI McCowan, Lesley/0000-0001-9915-7873; Leemaqz,
   Shalem/0000-0003-4616-8426; Grzeskowiak, Luke/0000-0001-8554-4696;
   Myers, Jenny/0000-0003-0913-2096; Bianco-Miotto,
   Tina/0000-0002-8431-5338; Kenny, Louise/0000-0002-9011-759X; Roberts,
   Claire/0000-0002-9250-2192; Walker, James/0000-0002-8922-083X; Poston,
   Lucilla/0000-0003-1100-2821
FU Premier's Science and Research Fund, South Australian Government; New
   Enterprise Research Fund, Foundation for Research Science and
   Technology; Health Research Council [04/198]; Evelyn Bond Fund, Auckland
   District Health Board Charitable Trust; Health Research Board of Ireland
   [CSA/2007/2]; National Health Service NEAT Grant [FSD025]; Biotechnology
   and Biological Sciences Research council [GT084]; University of
   Manchester Proof of Concept Funding (University of Manchester); Guy's
   and St. Thomas' Charity (King's College London); Tommy's charity (King's
   College London); Tommy's charity (University of Manchester); Cerebra UK
   (University of Leeds); NHMRC Centre for Research Excellence
   [GNT1099422]; Australian National Health and Medical Research Council
   (NHMRC) [1070421]; Science Foundation Ireland [12/RC/2272]; National
   Health and Medical Research Council (NHMRC) [GNT1020749]; National
   Health and Medical Research Council of Australia [1070421] Funding
   Source: NHMRC
FX The SCOPE database is provided and maintained by MedSciNet AB
   (http://medscinet.com).The Australian SCOPE study was funded by the
   Premier's Science and Research Fund, South Australian Government
   (http://www.dfeest.sa.gov.au/science-
   research/premiers-research-and-industry-fund). The New Zealand SCOPE
   study was funded by the New Enterprise Research Fund, Foundation for
   Research Science and Technology; Health Research Council (04/198);
   Evelyn Bond Fund, Auckland District Health Board Charitable Trust. The
   Irish SCOPE study was funded by the Health Research Board of Ireland
   (CSA/2007/2; http://www.hrb.ie).The UK SCOPE study was funded by
   National Health Service NEAT Grant (Neat Grant FSD025), Biotechnology
   and Biological Sciences Research council (www.bbsrc.ac.uk/funding;
   GT084) and University of Manchester Proof of Concept Funding (University
   of Manchester); Guy's and St. Thomas' Charity (King's College London)
   and Tommy's charity (http://www.tommys.org/; King's College London and
   University of Manchester); and Cerebra UK (www.cerebra.org.uk;
   University of Leeds). JAG was supported by the NHMRC Centre for Research
   Excellence (GNT1099422) awarded to CTR and GAD. LEG is supported by an
   Australian National Health and Medical Research Council (NHMRC) Early
   Career Fellowship (ID 1070421). LCK is supported by a Science Foundation
   Ireland Program Grant for INFANT (12/RC/2272). CTR was supported by a
   National Health and Medical Research Council (NHMRC) Senior Research
   Fellowship (GNT1020749). The funders had no role in study design, data
   collection and analysis, decision to publish, or preparation of the
   manuscript.
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NR 61
TC 116
Z9 123
U1 0
U2 6
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1549-1676
J9 PLOS MED
JI PLos Med.
PD DEC
PY 2018
VL 15
IS 12
AR e1002710
DI 10.1371/journal.pmed.1002710
PG 16
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA HG2YC
UT WOS:000454833300003
PM 30513077
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Sharma, P
   Yadav, RK
   Khadgawat, R
   Dada, R
AF Sharma, Piyush
   Yadav, Raj Kumar
   Khadgawat, Rajesh
   Dada, Rima
TI Transcriptional modulation of inflammation, and aging in Indian obese
   adults following a 12-week yoga-based lifestyle intervention: A
   randomized controlled trial
SO FRONTIERS IN MEDICINE
LA English
DT Article
DE aging; inflammation; obesity; oxidative stress; yoga
ID BREAST-CANCER SURVIVORS; GENE-EXPRESSION; OXIDATIVE STRESS; METABOLIC
   SYNDROME; PHYSICAL-ACTIVITY; CARDIOVASCULAR-DISEASE; CIGARETTE-SMOKING;
   RISK-FACTORS; VITAMIN-D; KAPPA-B
AB IntroductionObesity is one of the major global problems in today's world, both in children, and the adult age group. Current evidence suggests obesity alters the expression of various genes related to oxidative stress, inflammation, and aging. In recent times complementary therapy like yoga-based lifestyle intervention (YBLI) is used as an adjunct therapy to modern medicine. This study examines the efficacy of 12 weeks of yoga-based lifestyle intervention with standard care (SC) on the expression of genes related to oxidative stress, inflammation, and aging in obese adults. MethodsThis was a two-arm parallel randomized control trial implemented at Integral Health Clinic (IHC), an outpatient facility that regularly conducted YBLI programs for the prevention of lifestyle diseases like obesity and diabetes in the Department of Physiology, All India Institute of Medical Sciences (AIIMS), New Delhi. Blood samples at baseline and weeks 2,4, and 12 were collected from 72 adults (male n = 21; female n = 51) of age 20-45 years with a body-mass index (BMI) of 25-35 kg/m(2) who were randomized to receive either a 12-week SC (n = 36) or YBLI (n = 36). SC included recommendations for the management of obesity as per Indian guidelines including a low-calorie individualized diet and physical activity. Asana (physical postures), pranayama (breathing exercises), and meditation were all part of the YBLI. Primary outcomes were relative fold change in the expression of genes associated with oxidative stress [Nuclear factor-kappa B (NF-Kappa B)], inflammation [Tumor necrosis factor-alpha (TNF alpha), interleukin-6 (IL-6)], and aging [human telomerase reverse transcriptase (TERT)] in peripheral blood mononuclear cells between the two groups at week-12. ResultsThere were no significant changes in fold change of TERT, IL-6, and NF-kappa B between the groups at week 12. The relative fold change of TERT was significantly greater in the YBLI group (p = <0.0001) vs the SC group at 2 weeks. The relative fold change of TNF alpha was significantly lower at week 12 in YBLI though the change was not continuous and reliable. Within both groups, TERT expression was significantly increased at week 2 though the change was greater in the YBLI group (p < 0.0001). TNF alpha gene expression was significantly lower at weeks 2 and 4, compared to baseline level, in the SC group but it increased at week 12. ConclusionThe results while did not confirm our hypothesis, are important to share with the scientific society, to be able to improve prospective study designs and find optimal time/intervention/biological marker settings for this highly important scientific field. The results are suggestive of a positive impact of YBLI and SC on the fold change of aging-related TERT gene in obesity, though the benefit was not evident till week 12. However, the results should be evaluated with caution and in light of other published studies. To better understand the positive effects of YBLI on oxidative stress, inflammation, and aging-related gene expression in obesity, larger studies are recommended.
C1 [Sharma, Piyush; Yadav, Raj Kumar] All India Inst Med Sci, Dept Physiol, Integral Hlth & Wellness Clin, New Delhi, India.
   [Yadav, Raj Kumar; Khadgawat, Rajesh] All India Inst Med Sci, Dept Endocrinol Metab & Diabet, New Delhi, India.
   [Dada, Rima] All India Inst Med Sci, Dept Anat, New Delhi, India.
C3 All India Institute of Medical Sciences (AIIMS) New Delhi; All India
   Institute of Medical Sciences (AIIMS) New Delhi; All India Institute of
   Medical Sciences (AIIMS) New Delhi
RP Yadav, RK (corresponding author), All India Inst Med Sci, Dept Physiol, Integral Hlth & Wellness Clin, New Delhi, India.; Yadav, RK (corresponding author), All India Inst Med Sci, Dept Endocrinol Metab & Diabet, New Delhi, India.
EM raj3kr@gmail.com
RI Yadav, Raj Kumar/AFT-0686-2022; Sharma, Piyush/LJL-6107-2024
OI Sharma, Dr. Piyush/0000-0002-8705-8699; Yadav, Raj
   Kumar/0000-0002-5066-7028
FU All-India Institute of Medical Sciences, New Delhi; Indian Council of
   Medical Research, Government of India; Department of Science and
   Technology, SATYAM, Government of India;  [3/1/2(20)/OBS/2019-NCD-II]
FX Authors are grateful to the All India Institute of Medical Sciences, New
   Delhi, the Indian Council of Medical Research, Government of India, and
   Department of Science and Technology, SATYAM, Government of India for
   providing financial support.
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NR 67
TC 4
Z9 4
U1 1
U2 13
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 2296-858X
J9 FRONT MED-LAUSANNE
JI Front. Med.
PD AUG 8
PY 2022
VL 9
AR 898293
DI 10.3389/fmed.2022.898293
PG 16
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 3X9DE
UT WOS:000843332400001
PM 36004368
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Patterson, WB
   Glasson, J
   Naik, N
   Jones, RB
   Berger, PK
   Plows, JF
   Minor, HA
   Lurmann, F
   Goran, MI
   Alderete, TL
AF Patterson, William B.
   Glasson, Jessica
   Naik, Noopur
   Jones, Roshonda B.
   Berger, Paige K.
   Plows, Jasmine F.
   Minor, Hilary A.
   Lurmann, Frederick
   Goran, Michael, I
   Alderete, Tanya L.
TI Prenatal exposure to ambient air pollutants and early infant growth and
   adiposity in the Southern California Mother's Milk Study
SO ENVIRONMENTAL HEALTH
LA English
DT Article
DE Air pollution; PM2 5; Prenatal; Childhood obesity; DOHaD; Infant health
ID MITOCHONDRIAL-DNA CONTENT; FINE PARTICULATE MATTER; BODY-MASS INDEX;
   POLLUTION EXPOSURE; MATERNAL EXPOSURE; EARLY-CHILDHOOD; BIRTH-WEIGHT;
   TRAFFIC POLLUTION; OXIDATIVE STRESS; RISK-FACTORS
AB BackgroundPrior epidemiological and animal work has linked in utero exposure to ambient air pollutants (AAP) with accelerated postnatal weight gain, which is predictive of increased cardiometabolic risk factors in childhood and adolescence. However, few studies have assessed changes in infant body composition or multiple pollutant exposures. Therefore, the objective of this study was to examine relationships between prenatal residential AAP exposure with infant growth and adiposity.MethodsResidential exposure to AAP (particulate matter<2.5 and 10 microns in aerodynamic diameter [PM2.5, PM10]; nitrogen dioxide [NO2]; ozone [O-3]; oxidative capacity [O-x(wt): redox-weighted oxidative potential of O-3 and NO2]) was modeled by spatial interpolation of monitoring stations via an inverse distance-squared weighting (IDW2) algorithm for 123 participants from the longitudinal Mother's Milk Study, an ongoing cohort of Hispanic mother-infant dyads from Southern California. Outcomes included changes in infant growth (weight, length), total subcutaneous fat (TSF; calculated via infant skinfold thickness measures) and fat distribution (umbilical circumference, central to total subcutaneous fat [CTSF]) and were calculated by subtracting 1-month measures from 6-month measures. Multivariable linear regression was performed to examine relationships between prenatal AAP exposure and infant outcomes. Models adjusted for maternal age, pre-pregnancy body mass index, socioeconomic status, infant age, sex, and breastfeeding frequency. Sex interactions were tested, and effects are reported for each standard deviation increase in exposure.ResultsNO(2) was associated with greater infant weight gain (beta=0.14, p=0.02) and TSF (beta=1.69, p=0.02). PM10 and PM2.5 were associated with change in umbilical circumference (beta=0.73, p=0.003) and TSF (beta=1.53, p=0.04), respectively. Associations of O-x(wt) (p(interactions)<0.10) with infant length change, umbilical circumference, and CTSF were modified by infant sex. O-x(wt) was associated with attenuated infant length change among males (beta=-0.60, p=0.01), but not females (beta=0.16, p=0.49); umbilical circumference among females (beta=0.92, p=0.009), but not males (beta=-0.00, p=0.99); and CTSF among males (beta=0.01, p=0.03), but not females (beta=0.00, p=0.51).ConclusionPrenatal AAP exposure was associated with increased weight gain and anthropometric measures from 1-to-6 months of life among Hispanic infants. Sex-specific associations suggest differential consequences of in utero oxidative stress. These results indicate that prenatal AAP exposure may alter infant growth, which has potential to increase childhood obesity risk.
C1 [Patterson, William B.; Glasson, Jessica; Naik, Noopur; Alderete, Tanya L.] Univ Colorado, Dept Integrat Physiol, Boulder, CO 80309 USA.
   [Jones, Roshonda B.; Berger, Paige K.; Plows, Jasmine F.; Goran, Michael, I] Univ Southern Calif, Childrens Hosp Los Angeles, Dept Pediat, Saban Res Inst, Los Angeles, CA 90007 USA.
   [Minor, Hilary A.; Lurmann, Frederick] Sonoma Technol Inc, Petaluma, CA USA.
C3 University of Colorado System; University of Colorado Boulder;
   University of Southern California; Children's Hospital Los Angeles;
   Sonoma Technology, Inc.
RP Alderete, TL (corresponding author), Univ Colorado, Dept Integrat Physiol, Boulder, CO 80309 USA.
EM tanya.alderete@colorado.edu
RI Alderete, Tanya/H-3356-2019; Plows, Jasmine/S-9565-2019; Patterson,
   William/ABA-4261-2021
OI Alderete, Tanya/0000-0002-7751-9543; Patterson,
   William/0000-0001-8355-0857; Berger, Paige/0000-0003-1670-5147
FU NIH NIDDK [R01 DK11079]; Gerber Foundation [15PN-013]; NIEHS [R00
   ES027853]; Health Effects Institute Rosenblith Award; Eunice Kennedy
   Shriver National Institute of Child Health and Human Development
   [K99HD098288] Funding Source: NIH RePORTER
FX This work was supported by the NIH NIDDK (R01 DK11079), The Gerber
   Foundation (15PN-013), NIEHS (R00 ES027853), and the Health Effects
   Institute Rosenblith Award. Design of the study; collection, analysis,
   and interpretation of data; and writing the manuscript was strictly the
   responsibility of the authors.
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NR 72
TC 33
Z9 34
U1 2
U2 9
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1476-069X
J9 ENVIRON HEALTH-GLOB
JI Environ. Health
PD JUN 5
PY 2021
VL 20
IS 1
AR 67
DI 10.1186/s12940-021-00753-8
PG 12
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA SR2HI
UT WOS:000660864100002
PM 34090448
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Liu, LL
   Li, ZQ
   Ye, WR
   Peng, P
   Wang, YR
   Wan, LQ
   Li, JN
   Zhang, M
   Wang, YH
   Liu, RQ
   Xu, DY
   Zhang, JJ
AF Liu, Leiling
   Li, Zhiqi
   Ye, Wenrui
   Peng, Pu
   Wang, Yurong
   Wan, Luqing
   Li, Jiangnan
   Zhang, Mei
   Wang, Yihua
   Liu, Runqi
   Xu, Danyan
   Zhang, Jingjing
TI Safety and effects of anti-obesity medications on weight loss,
   cardiometabolic, and psychological outcomes in people living with
   overweight or obesity: a systematic review and meta-analysis
SO ECLINICALMEDICINE
LA English
DT Article
DE Overweight; Obesity; Anti-obesity medications; Randomised controlled
   trials; Meta-analysis
ID ALL-CAUSE MORTALITY; BODY-MASS INDEX; CARDIOVASCULAR OUTCOMES; RECEPTOR
   AGONISTS; ASSOCIATION; MANAGEMENT; DISEASE; ADULTS; RISK
AB Background Overweight and obesity pose serious health challenges for individuals and societies. This study aims to facilitate personalised treatment of obesity by summarising recent research on weight-loss pharmacotherapies, with a focus on their effects on weight reduction, cardiometabolic health, psychological outcomes, and adverse events. Methods This systematic review and meta-analysis included searches of Web of Science, PubMed, and Cochrane Central Register of Controlled Trials from inception to June 8, 2024. Randomised controlled trials evaluating weight-loss pharmacotherapies approved by the Food and Drug Administration (FDA) or European Medicines Agency (EMA) for treating overweight or obesity were included. Primary outcomes included changes in body weight, cardiometabolic indicators, psychological outcomes, and adverse events. Summary data was extracted from published reports. Random-effects meta-analyses were used to calculate weighted mean differences (WMDs), risk ratios (RRs), and 95% confidence intervals (CI). The Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) system was used to assess the certainty of evidence for each pooled analysis. PROSPERO registration: CRD42024547905. Findings A total of 154 randomised controlled trials (n = 112,515 participants) were included. Tirzepatide had the greatest weight-loss effect (WMD -11.69, 95% CI -19.22 to -4.15; P = 0.0024; I-2 = 100.0%; moderate certainty), followed by semaglutide (-8.48, -12.68 to -4.27; P < 0.0001; I-2 = 100.0%; moderate certainty). Tirzepatide had the strongest antihypertensive effect on both systolic (WMD -5.74, -9.00 to -2.48; P = 0.0006; I-2 = 99.8%; moderate certainty) and diastolic blood pressure (WMD -2.91, -4.97 to -0.85; P = 0.0056; I-2 = 99.8%; moderate certainty) and best reduced triglycerides (WMD -0.77, -0.85 to -0.69; P < 0.0001; I-2 = 3.2%; high certainty), fasting glucose (WMD -3.06, -5.53 to -0.59; P = 0.015; I-2 = 100.0%; moderate certainty), insulin (WMD -4.91, -8.15 to -1.68; P = 0.0029; I-2 = 97.0%; moderate certainty), and glycated haemoglobin levels (WMD -1.27, -1.82 to -0.73; P < 0.0001; I-2 = 100.0%; moderate certainty). Semaglutide (RR 0.83, 0.74-0.92; P < 0.0001; I-2 = 0.0%; high certainty) and liraglutide (0.87, 0.79-0.96; P = 0.0059; I-2 = 0.0%; high certainty) reduced the risk of major adverse cardiovascular events (MACEs). However, all three medications were associated with adverse gastrointestinal effects. Naltrexone/bupropion increased the risk of elevated blood pressure (RR 1.72, 1.04-2.85; P = 0.036; I-2 = 0.0%; high certainty). Topiramate increased depression risk (RR 1.62, 1.14 to 2.30; P = 0.0077; I-2 = 0.0%; high certainty), and phentermine/topiramate raised concerns about anxiety (RR 1.91, 1.09 to 3.35; P = 0.025; I-2 = 29.5%; high certainty), sleep disorders (RR 1.55, 1.24-1.93; P < 0.0001; I-2 = 0.0%; high certainty), and irritability (RR 3.31, 1.69-6.47; P < 0.0001; I-2 = 0.0%; high certainty). No medication increased the risk of serious adverse events. Interpretation For weight reduction, tirzepatide is the top choice, followed by semaglutide. Considering cardiometabolic risk factors, tirzepatide shows the best blood pressure- and glucose-lowering benefits, while semaglutide and liraglutide reduce the risk of MACEs. Naltrexone/bupropion carries a risk of increased blood pressure.
   Phentermine/topiramate should be used with caution due to its higher risk of psychological side effects. Despite limitations related to study heterogeneity, these fi ndings provide valuable insights for weight management strategies across diverse individuals.
C1 [Liu, Leiling; Wang, Yurong; Wan, Luqing; Li, Jiangnan; Zhang, Mei; Xu, Danyan] Cent South Univ, Xiangya Hosp 2, Dept Cardiovasc Med, Changsha, Hunan, Peoples R China.
   [Li, Zhiqi; Zhang, Jingjing] Cent South Univ, Xiangya Hosp 2, Metab Syndrome Res Ctr, Dept Metab & Endocrinol,Natl Clin Res Ctr Metab Di, Changsha 410011, Hunan, Peoples R China.
   [Ye, Wenrui] Xiangya Hosp, Dept Neurosurg, Changsha, Hunan, Peoples R China.
   [Peng, Pu; Wang, Yihua] Cent South Univ, Xiangya Hosp 2, Natl Clin Res Ctr Mental Disorders, Dept Psychiat, Changsha, Hunan, Peoples R China.
   [Peng, Pu; Wang, Yihua] Cent South Univ, Xiangya Hosp 2, Natl Ctr Mental Disorders, Changsha, Hunan, Peoples R China.
   [Liu, Runqi] UCL, Inst Global Hlth, Fac Populat Hlth Sci, London, England.
C3 Central South University; Central South University; Central South
   University; Central South University; Central South University;
   University of London; University College London
RP Zhang, JJ (corresponding author), Cent South Univ, Xiangya Hosp 2, Metab Syndrome Res Ctr, Dept Metab & Endocrinol,Natl Clin Res Ctr Metab Di, Changsha 410011, Hunan, Peoples R China.; Xu, DY (corresponding author), Cent South Univ, Xiangya Hosp 2, Inst Lipid & Atherosclerosis, Key Lab Hunan Prov,Dept Cardiovasc Med, Changsha 410011, Hunan, Peoples R China.
EM xudanyan02@csu.edu; Doctorzhangjj@csu.edu.cn
RI Wang, Yurong/LUZ-9973-2024; Liu, Runqi/MTF-2391-2025; Zhang,
   Jingjing/LFU-2029-2024
FU National Natural Science Foundation of China [82370807, 81871858,
   82172550]; Leading Talents Program of Hunan Province [2022RC3078];
   Fundamental Research Funds for the Central Universities of Central South
   University [2024ZZTS0166]
FX Acknowledgements We acknowledge funding support from the National
   Natural Science Foundation of China (82370807, 81871858, and 82172550) ,
   Leading Talents Program of Hunan Province (2022RC3078) , and Fundamental
   Research Funds for the Central Universities of Central South University
   (2024ZZTS0166) . We also acknowledge the assistance of Jiaxin Liu,
   Tuotuo Liu, Xiaowu Li, and Lei Dong for their assistances with data
   visualisations.
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NR 54
TC 3
Z9 3
U1 23
U2 23
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
EI 2589-5370
J9 ECLINICALMEDICINE
JI EClinicalMedicine
PD JAN
PY 2025
VL 79
AR 103020
DI 10.1016/j.eclinm.2024.103020
PG 21
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA T4M0B
UT WOS:001404753800001
PM 39834714
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Storto, G
   Sorrentino, AR
   Pellegrino, T
   Liuzzi, R
   Petretta, M
   Cuocolo, A
AF Storto, Giovanni
   Sorrentino, Anna Rita
   Pellegrino, Teresa
   Liuzzi, Raffaele
   Petretta, Mario
   Cuocolo, Alberto
TI Assessment of coronary flow reserve by sestamibi imaging in patients
   with typical chest pain and normal coronary arteries
SO EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
LA English
DT Article
DE SPECT imaging; coronary flow reserve; chest pain
ID MYOCARDIAL BLOOD-FLOW; POSITRON EMISSION TOMOGRAPHY; SYNDROME-X;
   ANGINA-PECTORIS; ENDOTHELIAL DYSFUNCTION; ANGIOGRAMS; PERFUSION;
   DISEASE; QUANTIFICATION; VASOMOTION
AB Purpose We assessed coronary flow reserve ( CFR) by sestamibi imaging in patients with typical chest pain, positive exercise stress test and normal coronary vessels. Methods Thirty- five patients with typical chest pain and normal angiogram and 12 control subjects with atypical chest pain underwent dipyridamole/ rest Tc-99m- sestamibi imaging. Myocardial blood flow ( MBF) was estimated by measuring first transit counts in the pulmonary artery and myocardial counts from SPECT images. Estimated CFR was expressed as the ratio of stress to rest MBF. Rest MBF and CFR were corrected for rate - pressure product ( RPP) and expressed as normalised MBF ( MBFn) and normalised CFR ( CFRn). Coronary vascular resistances ( CVR) were calculated as the ratio between mean arterial pressure and estimated MBF.
   Results At rest, estimated MBF and MBFn were lower in controls than in patients ( 0.98 +/- 0.4 vs 1.30 +/- 0.3 counts/ pixel/ s and 1.14 +/- 0.5 vs 1.64 +/- 0.6 counts/ pixel/ s, respectively, both p< 0.02). Stress MBF was not different between controls and patients ( 2.34 +/- 0.8 vs 2.01 +/- 0.7 counts/ pixel/ s, p= NS). Estimated CFR was 2.40 +/- 0.3 in controls and 1.54 +/- 0.3 in patients ( p< 0.0001). After correction for the RPP, CFRn was still higher in controls than in patients ( 2.1 +/- 0.5 vs 1.29 +/- 0.5, p< 0.0001). At baseline, CVR values were lower ( p< 0.01) in patients than in controls. Dipyridamoleinduced changes in CVR were greater ( p< 0.0001) in controls (- 63%) than in patients (- 35%). In the overall study population, a significant correlation between dipyridamole-induced changes in CVR and CFR was observed ( r=- 0.88, p< 0.0001).
   Conclusion SPECT might represent a useful non- invasive method for assessing coronary vascular function in patients with angina and a normal coronary angiogram.
C1 Univ Naples Federico II, Inst Biostruct & Bioimages, Dept Biomorphol & Funct Sci, Natl Res Council, Naples, Italy.
   Univ Naples Federico II, Dept Internal Med, Cardiovasc & Immunol Sci, Naples, Italy.
C3 Consiglio Nazionale delle Ricerche (CNR); Istituto di Biostrutture e
   Bioimmagini (IBB-CNR); University of Naples Federico II; University of
   Naples Federico II
RP Cuocolo, A (corresponding author), Univ Naples Federico II, Inst Biostruct & Bioimages, Dept Biomorphol & Funct Sci, Natl Res Council, Naples, Italy.
EM cuocolo@unina.it
RI Liuzzi, Raffaele/AIC-0886-2022; Cuocolo, Alberto/AAI-7148-2020;
   Pellegrino, teresa/G-6417-2010; Storto, Giovanni/AAC-2517-2022;
   Petretta, Mario/K-9892-2015; PELLEGRINO1, TERESA/M-6799-2016
OI Storto, Giovanni/0000-0002-6168-5598; Petretta,
   Mario/0000-0002-8001-4298; Cuocolo, Alberto/0000-0003-3431-7658;
   PELLEGRINO1, TERESA/0000-0003-2010-5865; liuzzi,
   raffaele/0000-0002-2350-6691
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NR 35
TC 20
Z9 20
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1619-7070
EI 1619-7089
J9 EUR J NUCL MED MOL I
JI Eur. J. Nucl. Med. Mol. Imaging
PD AUG
PY 2007
VL 34
IS 8
BP 1156
EP 1161
DI 10.1007/s00259-006-0333-x
PG 6
WC Radiology, Nuclear Medicine & Medical Imaging
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Radiology, Nuclear Medicine & Medical Imaging
GA 202OB
UT WOS:000248911800004
PM 17206413
DA 2025-06-11
ER

PT J
AU Baraskar, K
   Thakur, P
   Shrivastava, R
   Shrivastava, VK
AF Baraskar, Kirti
   Thakur, Pratibha
   Shrivastava, Renu
   Shrivastava, Vinoy Kumar
TI Ameliorative effects of gallic acid on GLUT-4 expression and insulin
   resistance in high fat diet-induced obesity animal model mice, Mus
   musculus
SO JOURNAL OF DIABETES AND METABOLIC DISORDERS
LA English
DT Article
DE GLUT-4; IRS-1; Insulin resistance; Obesity; High Fat Diet; Gallic acid
ID TYPE-2 DIABETES-MELLITUS; OXIDATIVE STRESS; ER STRESS; INFLAMMATION;
   RATS
AB Reduced activity of glucose transporter type 4 isoform (GLUT-4), an insulin-sensitive glucose transporter distributed on the adipocytes, is associated with impaired insulin signaling. Insulin resistance resulting from alteration in glucose transport is responsible for exacerbating the emergence of metabolic abnormalities. The present study aimed to investigate the effects of the antidote gallic acid (GA) on expression-related changes in GLUT-4 and insulin receptor substrate-1 (IRS-1) in the visceral adipose tissue and on the subsequent development of insulin resistance in a high-fat diet (HFD)-induced obesity animal model. Methods: Twenty-four female Swiss albino mice were used and separated into the following four groups (six animals in each group): control group (standard pellet diet), HFD group, (60% HFD), HFD + GA group (60% HFD and GA 50 mg/kg body weight for 60 days), and GA group (GA 50 mg/kg body weight for 60 days). The effect of HFD on serum glucose, total cholesterol, triglycerides, high-density lipoprotein cholesterol (HDL), low-density lipoprotein (LDL) cholesterol, and insulin was evaluated. Additionally, homeostasis model assessment for insulin resistance (HOMA-IR) and glucose tolerance test (GTT) was performed. The serum antioxidative profile, which comprises oxidative parameters (superoxide dismutase [SOD], catalase [CAT], and glutathione peroxidase [GPx]) was measured. The effectiveness of GA against HFD-induced alteration in GLUT-4 and IRS-1 expression was also evaluated. Results: The experimental group that fed on GA + HFD had improved levels of serum triglycerides (p<0.001), cholesterol (p<0.05), and LDL cholesterol. GA administration also significantly improved hyperinsulinemia and HOMA-IR index (p<0.001) in HFD mice. GA improved GTT results (p<0.05); activity of SOD, CAT, and GPx (p<0.05); and upregulated mRNA expression of GLUT-4 and IRS-1(p<0.05) in the visceral adipose tissue in the HFD + GA experimental group. Conclusion: A link exists between insulin resistance, GLUT-4, and IRS-1 expression in the adipose tissue, and the initiation of metabolic syndrome, a condition characterized by obesity. GA may promote insulin signaling, glucose uptake, and lipid metabolism in the adipose tissues by mitigating oxidative stress. GA can also be used to manage obesity-related comorbidities including type 2 diabetes and dyslipidemia.
C1 [Baraskar, Kirti; Shrivastava, Vinoy Kumar] Barkatullah Univ, Biosci Dept, Endocrinol Unit, Bhopal 462026, Madhya Pradesh, India.
   [Thakur, Pratibha] Indira Gandhi Med Coll, Dept Med, Shimla 171001, Himachal Prades, India.
   [Shrivastava, Renu] Sri Sathya Sai Coll Women, Zool Dept, Bhopal 262024, Madhya Pradesh, India.
C3 Barkatullah University; Indira Gandhi Medical College & Hospital Shimla
RP Thakur, P (corresponding author), Indira Gandhi Med Coll, Dept Med, Shimla 171001, Himachal Prades, India.
EM sweety.baraskar@gmail.com; pratibha000136@gmail.com;
   renu_s2010@yahoo.co.in; vinoyks2001@yahoo.com
RI Thakur, Pratibha/X-8810-2019
OI Baraskar, Kirti/0000-0003-4137-4730; THAKUR,
   PRATIBHA/0000-0003-0429-7684
FU Council of Scientific &Industrial Research (CSIR), UGC, New Delhi, India
   [445/(CSIR-UGC NET JUNE 2018)]
FX We are thankful to the Council of Scientific &Industrial Research
   (CSIR), UGC, New Delhi, India for the financial support; UGC.Ref.
   No:445/(CSIR-UGC NET JUNE 2018).
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   Yoshida M, 2010, FEBS LETT, V584, P1217, DOI 10.1016/j.febslet.2010.02.034
NR 58
TC 6
Z9 6
U1 0
U2 2
PU SPRINGER INT PUBL AG
PI CHAM
PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND
EI 2251-6581
J9 J DIABETES METAB DIS
JI J. Diabetes Metab. Disord.
PD JUN
PY 2023
VL 22
IS 1
BP 721
EP 733
DI 10.1007/s40200-023-01194-5
EA FEB 2023
PG 13
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA LJ7G2
UT WOS:000934825300001
PM 37255787
OA Green Published
DA 2025-06-11
ER

PT J
AU Dai, WB
   Chen, C
   Dong, GT
   Li, GR
   Peng, WW
   Liu, X
   Yang, J
   Li, LY
   Xu, RY
   Hu, XJ
AF Dai, Weibo
   Chen, Chang
   Dong, Gengting
   Li, Guangru
   Peng, Weiwen
   Liu, Xin
   Yang, Jing
   Li, Leyu
   Xu, Ruiyan
   Hu, Xianjing
TI Alleviation of Fufang Fanshiliu decoction on type II diabetes mellitus
   by reducing insulin resistance: A comprehensive network prediction and
   experimental validation
SO JOURNAL OF ETHNOPHARMACOLOGY
LA English
DT Article
DE Fufang fanshiliu decoction; Type II diabetes Mellitus; Network
   pharmacology; Insulin resistance; Oxidative stress
ID OXIDATIVE STRESS; METABOLIC SYNDROME; HEPG2 CELLS; DISEASE; ETIOLOGY;
   ADULTS
AB Ethnopharmacological relevance: Fufang Fanshiliu decoction (FFSLD) is a Chinese herbal medicine prescription that has been used in type 2 diabetes mellitus (T2DM), while the underlying mechanism remains unclear. Aim of the study: To validate the efficacy and explore the potential mechanisms of FFSLD in treating T2DM via integrating a network pharmacological approach and experimental evaluation. Materials and methods: T2DM mice model induced by high-fat diet feeding combined with streptozotocin injection was selected to investigate the alleviation of FFSLD against T2DM, via detecting the levels of glucose, insulin, glucagon (GC), triglyceride (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C). Network pharmacological analysis was used to predict the potential mechanisms, including the pharmacokinetics and drug-likeness screening, active ingredients and potential targets prediction, network analysis, and enrichment analysis. The candidate bioactive molecules of FFSLD, and targets information excavated through TCMSP, Uniprot, GeneCards, OMIM databases, were combined for comprehensive analysis by constructing "drug-compound-target-disease " and "protein-protein interaction " networks. Enrichment analysis was performed via Gene Ontology (GO) and Koto Encyclopedia of Genes and Genomes (KEGG) databases. HepG2 insulin-resistance (IR) cells model induced by high glucose was used to verify the potential mechanisms of FFSLD against T2DM which were predicted by the network pharmacology. Results: The animal study showed that FFSLD significantly decreased the blood glucose, and reversed the abnormal levels of insulin, GC, TG, TC, HDL-C, and LDL-C in T2DM mice. Network pharmacological analysis indicated that 106 active compounds of FFSLD might be correlated with 628 targets in treating T2DM, and the mechanism would probably be related to insulin resistance that harbored a high response value (P = 5.88844 E-33) though regulating Akt1, ESR1, oxidoreductase activity, and JAK/STAT signalings. Experimental validation showed that FFSLD reduced the ROS level, up-regulated the expressions of p-AKT, Nrf-2, and ESR1, and down regulated the expressions of JAK2, STAT3, and Keap-1 in the HepG2-IR cells model. Conclusions: This study demonstrated that the therapeutic effect of FFSLD on T2DM was related to IR alleviation. The underlying mechanisms were associated with the regulation of PI3K/AKT, JAK/STAT, oxidative stress, and ESR signaling pathways.
C1 [Dai, Weibo; Chen, Chang; Dong, Gengting; Li, Guangru; Peng, Weiwen; Liu, Xin; Yang, Jing] Guangzhou Univ Chinese Med, Zhongshan Hosp, Pharmacol Lab, Zhongshan, Peoples R China.
   [Li, Leyu; Xu, Ruiyan] Guangzhou Univ Chinese Med, Zhongshan Hosp, Endocrinol Dept, Zhongshan, Peoples R China.
   [Hu, Xianjing] Guangdong Med Univ, Sch Pharm, Guangdong Prov Key Lab Res & Dev Nat Drugs, Dongguan 523808, Peoples R China.
   [Hu, Xianjing] Hong Kong Baptist Univ, Ctr Canc & Inflammat Res, Sch Chinese Med, Hong Kong, Peoples R China.
C3 Guangzhou University of Chinese Medicine; Guangzhou University of
   Chinese Medicine; Guangdong Medical University; Hong Kong Baptist
   University
RP Li, LY (corresponding author), Guangzhou Univ Chinese Med, Zhongshan Hosp, Endocrinol Dept, Zhongshan, Peoples R China.; Hu, XJ (corresponding author), Guangdong Med Univ, Sch Pharm, Guangdong Prov Key Lab Res & Dev Nat Drugs, Dongguan 523808, Peoples R China.
EM lileyu@139.com; huxj2003@163.com
RI Li, Guangru/Y-2020-2018
OI , Hu/0000-0001-8541-8542
FU National Natural Science Foundation of China [81503303]; Project of
   Guangdong Basic and Applied Basic Research Foundation [2022A1515011307];
   Project of Administration of Traditional Chinese Medicine of Guangdong
   Province of China [20182170]; Project of Science and Technology Bureau
   of Zhongshan, Guangdong, China [2018B1010, 2019B1044]
FX This work was financially supported by the National Natural Science
   Foundation of China (No. 81503303) , Project of Guangdong Basic and
   Applied Basic Research Foundation (No. 2022A1515011307) , Project of
   Administration of Traditional Chinese Medicine of Guangdong Province of
   China (No. 20182170) , Project of Science and Technology Bureau of
   Zhongshan, Guangdong, China (No. 2018B1010, 2019B1044) .
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NR 60
TC 14
Z9 14
U1 1
U2 43
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0378-8741
EI 1872-7573
J9 J ETHNOPHARMACOL
JI J. Ethnopharmacol.
PD AUG 10
PY 2022
VL 294
AR 115338
DI 10.1016/j.jep.2022.115338
EA MAY 2022
PG 16
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA 1S6PJ
UT WOS:000804170800003
PM 35568115
OA hybrid
DA 2025-06-11
ER

PT J
AU Pezel, T
   Unterseeh, T
   Hovasse, T
   Asselin, A
   Lefevre, T
   Chevalier, B
   Neylon, A
   Benamer, H
   Champagne, S
   Sanguineti, F
   Toupin, S
   Garot, P
   Garot, J
AF Pezel, Theo
   Unterseeh, Thierry
   Hovasse, Thomas
   Asselin, Anouk
   Lefevre, Thierry
   Chevalier, Bernard
   Neylon, Antoinette
   Benamer, Hakim
   Champagne, Stephane
   Sanguineti, Francesca
   Toupin, Solenn
   Garot, Philippe
   Garot, Jerome
TI Phenotypic Clustering of Patients With Newly Diagnosed Coronary Artery
   Disease Using Cardiovascular Magnetic Resonance and Coronary Computed
   Tomography Angiography
SO FRONTIERS IN CARDIOVASCULAR MEDICINE
LA English
DT Article
DE clustering; phenomapping; stress cardiovascular magnetic resonance
   imaging; coronary computed tomographic angiogram (CCTA); outcomes;
   ischemia; coronary artery disease
ID NORTH-AMERICAN SOCIETY; INCREMENTAL PROGNOSTIC VALUE; NUCLEAR
   CARDIOLOGY; HEART-ASSOCIATION; TASK-FORCE; COMMITTEE; COLLEGE;
   INTERVENTIONS; PREDICTION; RADIOLOGY
AB Background: Epidemiological characteristics and prognostic profiles of patients with newly diagnosed coronary artery disease (CAD) are heterogeneous. Therefore, providing individualized cardiovascular (CV) risk stratification and tailored prevention is crucial.Objective: Phenotypic unsupervised clustering integrating clinical, coronary computed tomography angiography (CCTA), and cardiac magnetic resonance (CMR) data were used to unveil pathophysiological differences between subgroups of patients with newly diagnosed CAD.Materials and Methods: Between 2008 and 2020, consecutive patients with newly diagnosed obstructive CAD on CCTA and further referred for vasodilator stress CMR were followed for the occurrence of major adverse cardiovascular events (MACE), defined by cardiovascular death or non-fatal myocardial infarction. For this exploratory work, a cluster analysis was performed on clinical, CCTA, and CMR variables, and associations between phenogroups and outcomes were assessed.Results: Among 2,210 patients who underwent both CCTA and CMR, 2,015 (46% men, mean 70 +/- 12 years) completed follow-up [median 6.8 (IQR 5.9-9.2) years], in which 277 experienced a MACE (13.7%). Three mutually exclusive and clinically distinct phenogroups (PG) were identified based upon unsupervised hierarchical clustering of principal components: (PG1) CAD in elderly patients with few traditional risk factors; (PG2) women with metabolic syndrome, calcified plaques on CCTA, and preserved left ventricular ejection fraction (LVEF); (PG3) younger men smokers with proximal non-calcified plaques on CCTA, myocardial scar, and reduced LVEF. Using survival analysis, the occurrence of MACE, cardiovascular mortality, and all-cause mortality (all p < 0.001) differed among the three PG, in which PG3 had the worse prognosis. In each PG, inducible ischemia was associated with MACE [PG1, Hazards Ratio (HR) = 3.09, 95% CI, 1.70-5.62; PG2, HR = 3.62, 95% CI, 2.31-5.7; PG3, HR = 3.55, 95% CI, 2.3-5.49; all p < 0.001]. The study presented some key limitations that may impact generalizability.Conclusions: Cluster analysis of clinical, CCTA, and CMR variables identified three phenogroups of patients with newly diagnosed CAD that were associated with distinct clinical and prognostic profiles. Inducible ischemia assessed by stress CMR remained associated with the occurrence of MACE within each phenogroup. Whether automated unsupervised phenogrouping of CAD patients may improve clinical decision-making should be further explored in prospective studies.
C1 [Pezel, Theo; Unterseeh, Thierry; Hovasse, Thomas; Champagne, Stephane; Sanguineti, Francesca; Garot, Philippe; Garot, Jerome] Hop Prive Jacques CARTIER, Inst Cardiovasc Paris Sud, Cardiovasc Magnet Resonance Lab, Ramsay Sante, Massy, France.
   [Pezel, Theo] Univ Paris, AP HP, Lariboisiere Hosp, Dept Cardiol,INSERM,UMRS 942, Paris, France.
   [Unterseeh, Thierry; Hovasse, Thomas; Lefevre, Thierry; Chevalier, Bernard; Neylon, Antoinette; Benamer, Hakim; Champagne, Stephane; Sanguineti, Francesca; Garot, Philippe] Hop Prive Jacques CARTIER, Inst Cardiovasc Paris Sud, Dept Computed Tomog Imaging & Intervent Cardiol, Ramsay Sante, Massy, France.
   [Toupin, Solenn] Siemens Healthcare France, Sci Partnerships Div, St Denis, France.
C3 Jacques Cartier Private Hospital; Universite Paris Saclay; Institut
   National de la Sante et de la Recherche Medicale (Inserm); Assistance
   Publique Hopitaux Paris (APHP); Universite Paris Cite; Hopital
   Universitaire Lariboisiere-Fernand-Widal - APHP; Jacques Cartier Private
   Hospital; Universite Paris Saclay; Siemens AG
RP Garot, J (corresponding author), Hop Prive Jacques CARTIER, Inst Cardiovasc Paris Sud, Cardiovasc Magnet Resonance Lab, Ramsay Sante, Massy, France.
EM jgarot@angio-icps.com
RI Chevalier, Bernard/AAU-2855-2021
OI Garot, Philippe/0009-0001-8960-7006
CR Abbara S, 2016, J CARDIOVASC COMPUT, V10, P435, DOI 10.1016/j.jcct.2016.10.002
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   van Rosendael AR, 2021, JAMA CARDIOL, V6, P1257, DOI 10.1001/jamacardio.2021.3055
NR 36
TC 13
Z9 13
U1 0
U2 1
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2297-055X
J9 FRONT CARDIOVASC MED
JI Front. Cardiovasc. Med.
PD NOV 18
PY 2021
VL 8
AR 760120
DI 10.3389/fcvm.2021.760120
PG 12
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA XI5PG
UT WOS:000726162700001
PM 34869675
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Rodriguez, ACI
   Epel, ES
   White, ML
   Standen, EC
   Seckl, JR
   Tomiyama, AJ
AF Rodriguez, Angela C. Incollingo
   Epel, Elissa S.
   White, Megan L.
   Standen, Erin C.
   Seckl, Jonathan R.
   Tomiyama, A. Janet
TI Hypothalamic-pituitary-adrenal axis dysregulation and cortisol activity
   in obesity: A systematic review
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Review
DE HPA axis; Cortisol; Obesity; BMI; Abdominal obesity; 11 beta-HSD
ID 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1; SUBCUTANEOUS
   ADIPOSE-TISSUE; STRESS-INDUCED CORTISOL; BODY-FAT DISTRIBUTION;
   UNDER-THE-CURVE; SALIVARY CORTISOL; INSULIN-RESISTANCE; ABDOMINAL
   OBESITY; DEXAMETHASONE-SUPPRESSION; METABOLIC SYNDROME
AB Background: Although there is substantial evidence of differential hypothalamic-pituitary-adrenal (HPA) axis activity in both generalized and abdominal obesity, consistent trends in obesity-related HPA axis perturbations have yet to be identified.
   Objectives: To systematically review the existing literature on HPA activity in obesity, identify possible explanations for inconsistencies in the literature, and suggest methodological improvements for future study.
   Data sources: Included papers used Pubmed, Google Scholar, and the University of California Library search engines with search terms body mass index (BMI), waist-to-hip ratio (WHR), waist circumference, sagittal diameter, abdominal versus peripheral body fat distribution, body fat percentage, DEXA, abdominal obesity, and cortisol with terms awakening response, slope, total daily output, reactivity, feedback sensitivity, long-term output, and 11 beta-HSD expression.
   Study eligibility criteria: Empirical research papers were eligible provided that they included at least one type of obesity (general or abdominal), measured at least one relevant cortisol parameter, and a priori tested for a relationship between obesity and cortisol.
   Results: A general pattern of findings emerged where greater abdominal fat is associated with greater responsivity of the HPA axis, reflected in morning awakening and acute stress reactivity, but some studies did show underresponsiveness. When examined in adipocytes, there is a clear upregulation of cortisol output (due to greater expression of 11 beta-HSD1), but in hepatic tissue this cortisol is downregulated. Overall obesity (BMI) appears to also be related to a hyperresponsive HPA axis in many but not all studies, such as when acute reactivity is examined.
   Limitations: The reviewed literature contains numerous inconsistencies and contradictions in research methodologies, sample characteristics, and results, which partially precluded the development of clear and reliable patterns of dysregulation in each investigated cortisol parameter.
   Conclusions and implications: The literature to date is inconclusive, which may well arise from differential effects of generalized obesity vs. abdominal obesity or from modulators such as sex, sex hormones, and chronic stress. While the relationship between obesity and adipocyte cortisol seems to be clear, further research is warranted to understand how adipocyte cortisol metabolism influences circulating cortisol levels and to establish consistent patterns of perturbations in adrenal cortisol activity in both generalized and abdominal obesity. (C) 2015 Elsevier Ltd. All rights reserved.
C1 [Rodriguez, Angela C. Incollingo; White, Megan L.; Standen, Erin C.; Tomiyama, A. Janet] Univ Calif Los Angeles, Los Angeles, CA 90095 USA.
   [Epel, Elissa S.] Univ Calif San Francisco, San Francisco, CA 94118 USA.
   [Seckl, Jonathan R.] Univ Edinburgh, Edinburgh EH1 1HT, Midlothian, Scotland.
C3 University of California System; University of California Los Angeles;
   University of California System; University of California San Francisco;
   University of Edinburgh
RP Tomiyama, AJ (corresponding author), Univ Calif Los Angeles, Dept Psychol, 502 Portola Plaza, Los Angeles, CA 90095 USA.
EM tomiyama@psych.ucla.edu
RI Epel, Elissa/ABI-6703-2022; Rodriguez, Angela/V-1857-2019; Standen,
   Erin/JWP-7684-2024
OI Standen, Erin/0000-0003-3975-7038; Incollingo Rodriguez,
   Angela/0000-0003-1609-4163
FU UCLA Faculty Career Development Award
FX This project was supported by funding from the UCLA Faculty Career
   Development Award.
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NR 90
TC 292
Z9 326
U1 1
U2 47
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
EI 1873-3360
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD DEC
PY 2015
VL 62
BP 301
EP 318
DI 10.1016/j.psyneuen.2015.08.014
PG 18
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA CW5UU
UT WOS:000365062900034
PM 26356039
OA Green Published
DA 2025-06-11
ER

PT J
AU Agouridis, AP
   Tsimihodimos, V
   Filippatos, TD
   Dimitriou, AA
   Tellis, CC
   Elisaf, MS
   Mikhailidis, DP
   Tselepis, AD
AF Agouridis, Aris P.
   Tsimihodimos, Vasilis
   Filippatos, Theodosios D.
   Dimitriou, Andromachi A.
   Tellis, Costantinos C.
   Elisaf, Moses S.
   Mikhailidis, Dimitri P.
   Tselepis, Alexandros D.
TI The effects of rosuvastatin alone or in combination with fenofibrate or
   omega 3 fatty acids on inflammation and oxidative stress in patients
   with mixed dyslipidemia
SO EXPERT OPINION ON PHARMACOTHERAPY
LA English
DT Review
DE fenofibrate; high sensitivity C-reactive protein; isoprostane
   8-iso-prostaglandin F2alpha; lipoprotein-associated phospholipase A2;
   omega 3 fatty acids; rosuvastatin
ID C-REACTIVE PROTEIN; CORONARY-HEART-DISEASE; LIPOPROTEIN-ASSOCIATED
   PHOSPHOLIPASE-A2; ACTIVATING-FACTOR-ACETYLHYDROLASE;
   LOW-DENSITY-LIPOPROTEIN; MIDDLE-AGED MEN; N-3 FATTY-ACIDS;
   CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; FOLLOW-UP
AB Objective: Mixed dyslipidemia, oxidative stress and inflammation are related to a high risk for cardiovascular events. The aim of this open-label randomized study was to compare the effects of high-dose rosuvastatin, low-dose rosuvastatin plus fenofibrate and low-dose rosuvastatin plus omega 3 fatty acids on inflammation and oxidative stress indices in patients with mixed dyslipidemia.
   Methods: Ninety patients with mixed dyslipidemia participated in the study. Patients were randomly allocated to receive rosuvastatin 40 mg (n = 30, group R), rosuvastatin 10 mg plus fenofibrate 200 mg (n = 30, group RF) or rosuvastatin 10 mg plus omega 3 fatty acids 2 g daily (n = 30, group R Omega). Plasma and high-density lipoprotein (HDL)-associated lipoprotein-associated phospholipase A2 (LpPLA2) activities, high-sensitivity C reactive protein (hsCRP), plasma isoprostane and paraoxonase (PON1) activities were measured at baseline and after 3 months of treatment.
   Results: Serum concentrations of non-HDL cholesterol and low-density lipoprotein cholesterol (LDL-C) were significantly reduced in all study groups. However, these changes were more pronounced in the rosuvastatin monotherapy group. In all treatment groups a significant reduction in total plasma LpPLA2 activity was observed (by 41, 38 and 30% for groups R, RF and RW, respectively). This decrease was greater in the R and RF groups compared with the RW combination (p < 0.05). HDL-LpPLA2 activity was increased more in the RF group (+43%) compared with the R and RW groups (+ 18% and + 35%, respectively; p < 0.05 for both comparisons). In all treatment groups there was a nonsignificant reduction in plasma 8-iso-PGF2 alpha levels. A 53% reduction of hsCRP levels was observed in the R group, while in the RF and RW groups the reduction was 28 and 23%, respectively (p < 0.05 and p < 0.01 for the comparisons of group R with groups RF and RW, respectively). No significant changes were observed in PON activities in all treatment groups.
   Conclusion: The greater non-HDL-C- and LDL-C-lowering efficiency of rosuvastatin monotherapy along with its more potent effect on LpPLA2 activity and hsCRP levels indicate that this regimen is a better treatment option for patients with mixed dyslipidemia.
C1 [Agouridis, Aris P.; Tsimihodimos, Vasilis; Filippatos, Theodosios D.; Elisaf, Moses S.] Univ Ioannina, Sch Med, Dept Internal Med, GR-45110 Ioannina, Greece.
   [Dimitriou, Andromachi A.; Tellis, Costantinos C.; Tselepis, Alexandros D.] Univ Ioannina, Biochem Lab, Dept Chem, GR-45110 Ioannina, Greece.
   [Mikhailidis, Dimitri P.] UCL, Sch Med, Dept Clin Biochem Vasc Dis Prevent Clin, London NW3 2QG, England.
C3 University of Ioannina; University of Ioannina; University of London;
   University College London; UCL Medical School
RP Tsimihodimos, V (corresponding author), Univ Ioannina, Sch Med, Dept Internal Med, GR-45110 Ioannina, Greece.
EM tsimiho@gmail.com
RI Mikhailidis, Dimitri/A-1869-2013; Tsimihodimos, Vasilis/AAN-9888-2021;
   Filippatos, Theodosios/I-6016-2016
OI Filippatos, Theodosios/0000-0002-1713-0923; ELISAF,
   MOSES/0000-0003-0505-078X; Agouridis, Aris/0000-0002-9749-5075;
   Tsimihodimos, Vasilis/0000-0003-1708-3415
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NR 48
TC 33
Z9 35
U1 0
U2 11
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 1465-6566
J9 EXPERT OPIN PHARMACO
JI Expert Opin. Pharmacother.
PD DEC
PY 2011
VL 12
IS 17
BP 2605
EP 2611
DI 10.1517/14656566.2011.591383
PG 7
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 847OE
UT WOS:000296981400002
PM 21714585
DA 2025-06-11
ER

PT S
AU Farrell, GC
   Haczeyni, F
   Chitturi, S
AF Farrell, Geoffrey C.
   Haczeyni, Fahrettin
   Chitturi, Shivakumar
BE Yu, J
TI Pathogenesis of NASH: How Metabolic Complications of Overnutrition
   Favour Lipotoxicity and Pro-Inflammatory Fatty Liver Disease
SO OBESITY, FATTY LIVER AND LIVER CANCER
SE Advances in Experimental Medicine and Biology
LA English
DT Article; Book Chapter
DE Overnutrition; Lipotoxicity; Nonalcoholic fatty liver disease;
   Inflammation
ID ENDOPLASMIC-RETICULUM STRESS; CHOLESTEROL-LOWERING DRUGS; CROWN-LIKE
   STRUCTURES; TOLL-LIKE RECEPTORS; NONALCOHOLIC STEATOHEPATITIS;
   INSULIN-RESISTANCE; DIETARY-CHOLESTEROL; CELL-DEATH; URSODEOXYCHOLIC
   ACID; OBESE MICE
AB Overnutrition, usually with obesity and genetic predisposition, lead to insulin resistance, which is an invariable accompaniment of nonalcoholic fatty liver disease (NAFLD). The associated metabolic abnormalities, pre- or established diabetes, hypertension and atherogenic dyslipidemia (clustered as metabolic syndrome) tend to be worse for nonalcoholic steatohepatitis (NASH), revealing it as part of a continuum of metabolic pathogenesis. The origins of hepatocellular injury and lobular inflammation which distinguish NASH from simple steatosis have intrigued investigators, but it is now widely accepted that NASH results from liver lipotoxicity. The key issue is not the quantity of liver fat but the type(s) of lipid molecules that accumulate, and how they are "packaged" to avoid subcellular injury. Possible lipotoxic mediators include free (unesterified) cholesterol, saturated free fatty acids, diacylglycerols, lysophosphatidyl-choline, sphingolipids and ceramide. Lipid droplets are intracellular storage organelles for non-structural lipid whose regulation is influenced by genetic polymorphisms, such as PNPLA3. Cells unable to sequester chemically reactive lipid molecules undergo mitochondrial injury, endoplasmic reticulum (ER) stress and autophagy, all processes of interest for NASH pathogenesis. Lipotoxicity kills hepatocytes by apoptosis, a highly regulated, noninflammatory form of cell death, but also by necrosis, necroptosis and pyroptosis; the latter involve mitochondrial injury, oxidative stress, activation of c-Jun N-terminal kinase (JNK) and release of danger-associated molecular patterns (DAMPs). DAMPs stimulate innate immunity by binding pattern recognition receptors, such as Toll-like receptor 4 (TLR4) and the NOD-like receptor protein 3 (NLRP3) inflammasome, which release a cascade of pro-inflammatory chemokines and cytokines. Thus, lipotoxic hepatocellular injury attracts inflammatory cells, particularly activated macrophages which surround ballooned hepatocytes as crown-like structures. In both experimental and human NASH, livers contain cholesterol crystals which are a second signal for NLRP3 activation; this causes interleukin (IL)-1 beta and IL18 secretion to attract and activate macrophages and neutrophils. Injured hepatocytes also liberate plasma membrane-derived extracellular vesicles; these have been shown to circulate in NASH and to be pro-inflammatory. The way metabolic dysfunction leads to lipotoxicity, innate immune responses and the resultant pattern of cellular inflammation in the liver are likely also relevant to hepatic fibrogenesis and hepatocarcinogenesis. Pinpointing the key molecules involved pharmacologically should eventually lead to effective pharmacotherapy against NASH.
C1 [Farrell, Geoffrey C.; Haczeyni, Fahrettin; Chitturi, Shivakumar] Australian Natl Univ, Sch Med, Woden, ACT, Australia.
   [Farrell, Geoffrey C.; Haczeyni, Fahrettin; Chitturi, Shivakumar] Australian Natl Univ, Canberra Hosp, Gastroenterol & Hepatol Unit, Woden, ACT, Australia.
C3 Australian National University; Australian National University; Canberra
   Hospital
RP Farrell, GC (corresponding author), Australian Natl Univ, Sch Med, Woden, ACT, Australia.; Farrell, GC (corresponding author), Australian Natl Univ, Canberra Hosp, Gastroenterol & Hepatol Unit, Woden, ACT, Australia.
EM geoff.farrell@anu.edu.au; fahrettin.haczeyni@anu.edu.au;
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NR 162
TC 132
Z9 145
U1 2
U2 46
PU SPRINGER-VERLAG SINGAPORE PTE LTD
PI SINGAPORE
PA 152 BEACH ROAD, #21-01/04 GATEWAY EAST, SINGAPORE, 189721, SINGAPORE
SN 0065-2598
EI 2214-8019
BN 978-981-10-8684-7; 978-981-10-8683-0
J9 ADV EXP MED BIOL
JI Adv.Exp.Med.Biol.
PY 2018
VL 1061
BP 19
EP 44
DI 10.1007/978-981-10-8684-7_3
D2 10.1007/978-981-10-8684-7
PG 26
WC Oncology; Gastroenterology & Hepatology; Medicine, Research &
   Experimental
WE Book Citation Index – Science (BKCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Gastroenterology & Hepatology; Research & Experimental
   Medicine
GA BL6JC
UT WOS:000454313800004
PM 29956204
DA 2025-06-11
ER

PT J
AU Li, QL
   Tomcik, K
   Zhang, SH
   Puchowicz, MA
   Zhang, GF
AF Li, Qingling
   Tomcik, Kristyen
   Zhang, Shenghui
   Puchowicz, Michelle A.
   Zhang, Guo-Fang
TI Dietary regulation of catabolic disposal of 4-hydroxynonenal analogs in
   rat liver
SO FREE RADICAL BIOLOGY AND MEDICINE
LA English
DT Article
DE 4-Hydroxynonenal; 4-Oxononenal; 1,4-Dihydroxynonene; Diet; Rat liver;
   Metabolism; Lipid peroxidation; Mass isotopomer analysis; Free radicals
ID LIPID-PEROXIDATION PRODUCT; HIGH-FAT DIET; SPONTANEOUSLY
   HYPERTENSIVE-RATS; OXIDATIVE STRESS; INSULIN-RESISTANCE;
   MASS-SPECTROMETRY; CARBONYL STRESS; ACID OXIDATION; MALONYL-COA; ADDUCTS
AB Our previous work in perfused rat livers has demonstrated that 4-hydroxynonenal (HNE) is catabolized predominantly via beta oxidation. Therefore, we hypothesized that perturbations in beta oxidation, such as diet-altered fatty acid oxidation activity, could lead to changes in HNE levels. To test our hypothesis, we (i) developed a simple and sensitive GC/MS method combined with mass isotopomer analysis to measure HNE and FINE analogs, 4-oxononenal (ONE) and 1,4-dihydroxynonene (DHN), and (ii) investigated the effects of four diets (standard, low-fat, ketogenic, and high-fat mix) on HNE, ONE, and DHN concentrations in rat livers. Our results showed that livers from rats fed the ketogenic diet or high-fat mix diet had high to omega-6 polyunsaturated fatty acid concentrations and markers of oxidative stress. However, high concentrations of HNE (1.6 +/- 0.5 nmol/g) and ONE (0.9 +/- 0.2 nmol/g) were found only in livers from rats fed the high-fat mix diet. Livers from rats fed the ketogenic diet had low HNE (0.8 +/- 0.1 nmol/g) and ONE (0.4 +/- 0.07 nmol/g), similar to rats fed the standard diet. A possible explanation is that the predominant pathway of FINE catabolism (i.e., beta oxidation) is activated in the liver by the ketogenic diet. This is consistent with a 10-fold decrease in malonyl-CoA in livers from rats fed a ketogenic diet compared to a standard diet. The accelerated catabolism of HNE lowers HNE and FINE analog concentrations in livers from rats fed the ketogenic diet. On the other hand, rats fed the high-fat mix diet had high rates of lipid synthesis and low rates of fatty acid oxidation, resulting in the slowing down of the catabolic disposal of HNE and HNE analogs. Thus, decreased HNE catabolism from a high-fat mix diet induces high concentrations of HNE and HNE analogs. The results of this work suggest a potential causal relationship to metabolic syndrome induced by Western diets (i.e., high-fat mix), as well as the effects of a ketogenic diet on the catabolism of lipid peroxidation products in liver. (C) 2011 Elsevier Inc. All rights reserved.
C1 [Li, Qingling; Tomcik, Kristyen; Zhang, Shenghui; Puchowicz, Michelle A.; Zhang, Guo-Fang] Case Western Reserve Univ, Dept Nutr, Cleveland, OH 44106 USA.
C3 University System of Ohio; Case Western Reserve University
RP Zhang, GF (corresponding author), Case Western Reserve Univ, Dept Nutr, Cleveland, OH 44106 USA.
EM gxz35@case.edu
RI Liu, Fang/HTN-2574-2023
OI Zhang, Guo-Fang/0000-0003-3484-5864; Tomcik,
   Kristyen/0000-0002-4241-4557
FU National Institutes of Health [R33DK070291, R01 ES013925]; Mouse
   Metabolic Phenotyping Center [U24 DK76169]; Cleveland Mt. Sinai Health
   Care Foundation
FX This work was supported, in whole or in part, by National Institutes of
   Health Roadmap Grant R33DK070291, NIH Grant R01 ES013925, and the Mouse
   Metabolic Phenotyping Center (U24 DK76169) (to Henri Brunengraber,
   Department of Nutrition, Case Western Reserve University). This work was
   also supported by a grant from the Cleveland Mt. Sinai Health Care
   Foundation.
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NR 73
TC 19
Z9 22
U1 0
U2 10
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0891-5849
EI 1873-4596
J9 FREE RADICAL BIO MED
JI Free Radic. Biol. Med.
PD MAR 15
PY 2012
VL 52
IS 6
BP 1043
EP 1053
DI 10.1016/j.freeradbiomed.2011.12.022
PG 11
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 901JU
UT WOS:000300964000008
PM 22245097
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Kwiecien, S
   Ptak-Belowska, A
   Krzysiek-Maczka, G
   Targosz, A
   Jasnos, K
   Magierowski, M
   Szczyrk, U
   Brzozowski, B
   Konturek, SJ
   Konturek, PC
   Brzozowski, T
AF Kwiecien, S.
   Ptak-Belowska, A.
   Krzysiek-Maczka, G.
   Targosz, A.
   Jasnos, K.
   Magierowski, M.
   Szczyrk, U.
   Brzozowski, B.
   Konturek, S. J.
   Konturek, P. C.
   Brzozowski, T.
TI ASYMMETRIC DIMETHYLARGININE, AN ENDOGENOUS INHIBITOR OF NITRIC OXIDE
   SYNTHASE, INTERACTS WITH GASTRIC OXIDATIVE METABOLISM AND ENHANCES
   STRESS-INDUCED GASTRIC LESIONS
SO JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
LA English
DT Article
DE asymmetric dimethylarginine; malonylaldehyde; superoxide dismutase;
   glutathione peroxidase; interleukin-1 beta; tumor necrosis factor-alpha;
   oxidative stress; water immersion restraint stress
ID MUCOSAL INJURY; SENSORY NERVES; DIABETIC-RATS; RISK-FACTOR; L-ARGININE;
   ASPIRIN; NO; GASTROPROTECTION; HYPERTENSION; CYTOKINES
AB Asymmetric dimethylarginine (ADMA) is an endogenous competitive inhibitor of nitric oxide (NO) synthase known to exert vasoconstriction of vascular bed. The elevation of ADMA has been considered as the cardiovascular risk factor associated with hyperlipidemia, hypercholesterolemia and metabolic syndrome. ADMA is produced by the action of dimethylarginine dimethylaminohydrolase (DDAH), which hydrolyzes ADMA to L-citrulline and dimethylamine. Previous studies have shown that endogenous NO plays an important role in the mechanism of gastric mucosal defense, but the role of ADMA in the pathogenesis of serious clinical entity, such as the acute gastric mucosal injury induced by stress has been little studied. In present study, we determined the effect of intragastric (i.g.) pretreatment with ADMA applied in graded doses ranging from 0.1 up to 20 mg/kg on gastric mucosal lesions induced by 3.5 h of water immersion and restraint stress (WRS). The number of gastric lesions was determined by planimetry and the gastric blood flow (GBF) was assessed by laser Doppler technique. The malondialdehyde and 4-hydroxynonenal (MDA+4-HNE) concentration, as an index of oxygen radical-lipid peroxidation was assessed in the gastric mucosa in rats exposed to WRS with or without ADMA administration. Proinflammatory cytokines IL-1 beta, TNF-alpha, superoxide dismutase (SOD) and glutathione peroxidase (GPx) mRNAs in the gastric mucosa and plasma levels of ADMA, IL-1 beta and TNF-alpha were analyzed by RT-PCR and ELISA, respectively. The exposure of rats to WRS for 3.5 h produced acute gastric lesions accompanied by a significant rise in the plasma ADMA levels and a significant fall in the GBF, an increase in MDA+4-HNE concentrations and the significant increase in the expression and release of IL-1 beta and TNF-alpha. The pretreatment with ADMA, applied i.g. 30 min before WRS dose-dependently, aggravated WRS damage and this effect was accompanied by a further significant fall in the GBF. The ADMA induced exacerbation of WRS lesions and the accompanying rise in the plasma ADMA levels and the fall in GBF were significantly attenuated by concurrent treatment with glyceryl trinitrate (GTN) (10 mg/kg i.g.) in the presence of ADMA. Administration of ADMA resulted in a significant decrease in the expression of SOD and GPx mRNAs and the up-regulation of mRNA for IL-1 beta and TNF-alpha followed by an increase in these plasma cytokine levels as compared to respective values observed in vehicle-pretreated animals. We conclude that 1) ADMA could be implicated in the mechanism of WRS-induced ulcerogenesis, 2) ADMA exacerbates WRS-induced gastric lesions due to enhancement in neutrophil dependent lipid peroxidation and overexpression and release of proinflammatory cytokines IL-1 beta and TNF-alpha and a potent depletion of antioxidative enzymes SOD and GPx expression and activity.
C1 [Kwiecien, S.; Ptak-Belowska, A.; Krzysiek-Maczka, G.; Targosz, A.; Jasnos, K.; Magierowski, M.; Szczyrk, U.; Konturek, S. J.; Brzozowski, T.] Jagiellonian Univ, Coll Med, Dept Physiol, PL-31531 Krakow, Poland.
   [Brzozowski, B.] Jagiellonian Univ, Coll Med, Dept Gastroenterol, PL-31531 Krakow, Poland.
   [Konturek, P. C.] Univ Jena, Teaching Hosp, Thuringia Clin Saalfeld, Dept Med, D-6900 Jena, Germany.
C3 Jagiellonian University; Collegium Medicum Jagiellonian University;
   Jagiellonian University; Collegium Medicum Jagiellonian University;
   Friedrich Schiller University of Jena
RP Kwiecien, S (corresponding author), Jagiellonian Univ, Coll Med, Dept Physiol, 16 Grzegorzecka St, PL-31531 Krakow, Poland.
EM skwiecien@cm-uj.krakow.pl
RI Magierowska, Katarzyna/LCE-2970-2024; Brzozowski, Bartosz/HTQ-6768-2023;
   Magierowski, Marcin/AFO-9432-2022
OI Magierowski, Marcin/0000-0003-0175-5600; Kwiecien,
   Slawomir/0000-0002-4806-8042
CR Altinkaynak K, 2003, POL J PHARMACOL, V55, P645
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NR 32
TC 37
Z9 40
U1 0
U2 5
PU POLISH PHYSIOLOGICAL SOC
PI GRZEGORZECKA
PA JAGIELLONIAN UNIV SCHOOL MED, INST PHYSIOLOGY, 31-531 KRAKOW, 16
   GRZEGORZECKA, POLAND
SN 0867-5910
J9 J PHYSIOL PHARMACOL
JI J. Physiol. Pharmacol.
PD OCT
PY 2012
VL 63
IS 5
BP 515
EP 524
PG 10
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA 060AL
UT WOS:000312747500009
PM 23211305
DA 2025-06-11
ER

PT J
AU Hussain, WG
   Shehzad, F
   Ahmad, R
   Akbar, A
AF Hussain, Waqas Ghulam
   Shehzad, Farrukh
   Ahmad, Rashid
   Akbar, Atif
TI Establishing growth charts for proposed body shape and size index of the
   Pakistani population, using quantile regression approach
SO SAGE OPEN MEDICINE
LA English
DT Article
DE Body shape and size index; anthropometric measures; body mass index;
   body surface area; quantile regression model; linear regression model
ID TO-HEIGHT RATIO; ALL-CAUSE MORTALITY; MASS INDEX; WAIST CIRCUMFERENCE;
   CARDIOMETABOLIC RISK; SCREENING TOOL; OBESITY; FAT; MEN; OVERWEIGHT
AB Background: Obesity leads to other fatal diseases like diabetes, cardiovascular diseases, depression, and some forms of cancer. Still, the well-known tool to measure obesity is the body mass index. But it usually failed in the measurement of adipose tissues. So, we present a novel anthropometric measure, called body shape and size index which is developed by the combination of major anthropometric determinants: body surface area, body mass index, weight, and height.
   Methods: This study is based on cross-sectional data consisting of 7224 individuals that were taken from the city Multan, Punjab, Pakistan. All the individuals, both males, and females, of age 2 years and above were included in the study except the pregnant women. The variables included in this study are gender, area (urban and rural), age (years), weight (kg), and height (meters). Growth charts of quantile regression are used for the inferential analysis of data. Comparison of proposed body shape and size index at different obesity levels has also been made to access the relationship of proposed body shape and size index with obesity.
   Results: The results show that the proposed body shape and size index has a great association with body surface area, body mass index, weight, height, and age. The proposed body shape and size index has a high negative association with body surface area, moderate negative association with body mass index and weight, and low negative association with height and age. According to growth charts of body shape and size index, after the age of 25 years, body shape and size index curves go upward while it smoothly goes downward at the age of 50 years but decreases in earlier ages. Body shape and size index showed a significant association with body shape and body size (body development) at the same time.
   Conclusion: Body shape and size index is found, generally linear with age, and increased with decreasing body mass index and body surface area. The proposed index has an indirect relationship with obesity. Body shape and size index with low values indicates a high risk of obesity. While, however, body shape and size index with high values indicates a low risk of obesity. Applications of the proposed body shape and size index are also presented in statistical modeling.
C1 [Hussain, Waqas Ghulam; Shehzad, Farrukh; Ahmad, Rashid] Islamia Univ Bahawalpur, Dept Stat, Bahawalpur 63100, Pakistan.
   [Akbar, Atif] Bahauddin Zakariya Univ, Dept Stat, Multan, Pakistan.
C3 Islamia University of Bahawalpur; Bahauddin Zakariya University
RP Shehzad, F (corresponding author), Islamia Univ Bahawalpur, Dept Stat, Bahawalpur 63100, Pakistan.
EM fshehzad.stat@gmail.com
RI Rather, Raouf/J-3509-2019; Akbar, Atif/AAE-1927-2020; Ghulam Hussain,
   Waqas/KXR-1872-2024
OI Ghulam Hussain, Waqas/0000-0002-1578-769X
CR Abarca-Gomez L., 2017, Lancet, V390, P2627, DOI DOI 10.1016/S0140-6736(17)32129-3
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NR 44
TC 1
Z9 1
U1 0
U2 0
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 2050-3121
J9 SAGE OPEN MED
JI SAGE Open Med.
PD AUG
PY 2021
VL 9
AR 20503121211036135
DI 10.1177/20503121211036135
PG 12
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA UE7SE
UT WOS:000688082800001
PM 34394930
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Liao, HQ
   Cheng, JP
   Pan, D
   Deng, ZH
   Liu, Y
   Jiang, JR
   Cai, JH
   He, BX
   Lei, M
   Li, HH
   Li, Y
   Xu, YT
   Tang, YM
AF Liao, Huanquan
   Cheng, Jinping
   Pan, Dong
   Deng, Zhenhong
   Liu, Ying
   Jiang, Jingru
   Cai, Jinhua
   He, Baixuan
   Lei, Ming
   Li, Honghong
   Li, Yi
   Xu, Yongteng
   Tang, Yamei
TI Association of earlier age at menopause with risk of incident dementia,
   brain structural indices and the potential mediators: a prospective
   community-based cohort study
SO ECLINICALMEDICINE
LA English
DT Article
DE Earlier age at menopause; Dementia; Brain structure; Mediator
ID REPRODUCTIVE PERIOD; PREMATURE MENOPAUSE; ALZHEIMERS-DISEASE; COGNITIVE
   FUNCTION; HYSTERECTOMY; DURATION; CANCER
AB Background To date, there is no homogeneous evidence of whether earlier age at menopause is associated with incident dementia. In addition, the underlying mechanism and driven mediators are largely unknown. We aimed to fill these knowledge gaps.
   Methods This community-based cohort study included 154,549 postmenopausal women without dementia at enrolment (between 2006 and 2010) from the UK Biobank who were followed up until June 2021. We followed up until June 2021. Age at menopause was entered as a categorical variable (<40, 40-49, and >= 50 years) with >= 50 years taken as a reference. The primary outcome was all-cause dementia in a time-to-event analysis and the secondary outcomes included Alzheimer's disease, vascular dementia, and other types of dementia. In addition, we investigated the association between magnetic resonance (MR) brain structure indices with earlier menopause, and explored the potential underlying driven mediators on the relationship between earlier menopause and dementia.
   Findings 2266 (1.47%) dementia cases were observed over a median follow- up period of 12.3 years. After adjusting for confounders, women with earlier menopause showed a higher risk of all-cause dementia compared with those >= 50 years (adjusted-HRs [ 95% CIs]: 1.21 [1.09-1.34] and 1.71 [1.38-2.11] in the 40-49 years and <40 years groups, respectively; P for trend <0.001). No significant interactions between earlier menopause and polygenic risk score, cardiometabolic factors, type of menopause, or hormone-replacement therapy strata were found. Earlier menopause was negatively associated with brain MR global and regional grey matter indices, and positively associated with white matter hyperintensity. The relationship between earlier menopause and dementia was partially mediated by menopause-related comorbidities including sleep disturbance, mental health disorder, frailty, chronic pain, and metabolic syndrome, with the proportion (95% CI) of mediation effect being 3.35% (2.18-5.40), 1.38% (1.05-3.20), 5.23% (3.12-7.83), 3.64% (2.88-5.62) and 3.01% (2.29-4.40), respectively. Multiple mediator analysis showed a combined effect being 13.21% (11.11-18.20).
   Interpretation Earlier age at menopause was associated with risk of incident dementia and deteriorating brain health. Further studies are warranted to clarify the underlying mechanisms by which earlier age at menopause is linked to an increased risk of dementia, and to determine public health strategies to attenuate this association. Copyright (c) 2023 The Author(s). Published by Elsevier Ltd.
C1 [Liao, Huanquan; Cheng, Jinping; Deng, Zhenhong; Liu, Ying; Jiang, Jingru; Cai, Jinhua; He, Baixuan; Lei, Ming; Li, Honghong; Li, Yi; Xu, Yongteng; Tang, Yamei] Sun Yat sen Univ, Sun Yat sen Mem Hosp, Dept Neurol, Guangzhou, Peoples R China.
   [Liao, Huanquan] Sun Yat sen Univ, Affiliated Hosp 7, Dept Neurol, Shenzhen, Peoples R China.
   [Pan, Dong] Sun Yat sen Univ, Affiliated Hosp 8, Dept Neurol, Shenzhen, Peoples R China.
   [Tang, Yamei] Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Guangdong Prov Key Lab Malignant Tumor Epigenet &, Guangzhou, Peoples R China.
   [Tang, Yamei] Sun Yat Sen Univ, Zhongshan Sch Med, Guangdong Prov Key Lab Brain Funct & Dis, Guangzhou, Peoples R China.
   [Tang, Yamei] Sun Yat Sen Univ, Guangzhou, Peoples R China.
C3 Sun Yat Sen University; Sun Yat Sen University; Sun Yat Sen University;
   Sun Yat Sen University; Sun Yat Sen University; Sun Yat Sen University
RP Tang, YM (corresponding author), Sun Yat Sen Univ, Guangzhou, Peoples R China.
EM tangym@mail.sysu.edu.cn
RI cheng, jinping/GLN-6785-2022; Liu, Ying/HJY-6264-2023; LI,
   HONGHONG/F-1189-2017; Lei, Ming/JAD-1050-2023; Pan, Dong/HHZ-2192-2022
OI Tang, Yamei/0000-0002-6353-6107; Cheng, Jinping/0000-0002-0560-6381;
   Liu, Ying/0009-0000-7018-0711; Pan, Dong/0000-0002-5952-5683
FU National Natural Science Foundation of China; Science and Technology
   Program of Guangzhou; Key Area Research and Development Program of
   Guangdong Province; China Postdoctoral Science Foundation; Guangdong
   Basic and Applied Basic Research Foundation
FX National Natural Science Foundation of China, the Science and Technology
   Program of Guangzhou, the Key Area Research and Development Program of
   Guangdong Province, the China Postdoctoral Science Foundation, andthe
   Guangdong Basic and Applied Basic Research Foundation
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NR 57
TC 17
Z9 17
U1 5
U2 21
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
EI 2589-5370
J9 ECLINICALMEDICINE
JI EClinicalMedicine
PD JUN
PY 2023
VL 60
AR 102033
DI 10.1016/j.eclinm.2023.102033
EA JUN 2023
PG 14
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA O5IZ1
UT WOS:001044158000001
PM 37396803
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Zelber-Sagi, S
   Carrieri, P
   Pericas, JM
   Ivancovsky-Wajcman, D
   Younossi, ZM
   Lazarus, JV
AF Zelber-Sagi, Shira
   Carrieri, Patrizia
   Pericas, Juan M.
   Ivancovsky-Wajcman, Dana
   Younossi, Zobair M.
   Lazarus, Jeffrey V.
TI Food inequity and insecurity and MASLD: burden, challenges, and
   interventions
SO NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
LA English
DT Review
ID FATTY LIVER-DISEASE; ALCOHOL-CONSUMPTION; MEDITERRANEAN DIET; SOCIAL
   DETERMINANTS; ETHNIC DISPARITIES; METABOLIC SYNDROME; PRACTICE GUIDANCE;
   RISK-FACTORS; HEALTH; OBESITY
AB Liver disease prevalence, severity, outcomes and hepatic risk factors (for example, unhealthy diet) are heavily affected by socioeconomic status and food insecurity. Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most prevalent liver disease globally and is likely to co-occur with other liver diseases associated with food insecurity. Though weight reduction and adopting a healthy diet can reverse the course of MASLD, gaps between recommendations and practice transcend individual responsibility and preference. Broader sociocultural determinants of food choices (social nutrition) include food insecurity, community and social norms and the local environment, including commercial pressures that target people experiencing poverty, ethnic minorities and children. Food insecurity is a barrier to a healthy diet, as a low-quality diet is often less expensive than a healthy one. Consequently, food insecurity is an 'upstream' risk factor for MASLD, advanced fibrosis and greater all-cause mortality among patients with liver disease. Intervening on food insecurity at four major levels (environment, policy, community and health care) can reduce the burden of liver disease, thereby reducing social and health inequities. In this Review, we report on the current research in the field, the need for implementing proven interventions, and the role liver specialists can have.
   Metabolic dysfunction-associated steatotic liver disease (MASLD) prevalence is increasing worldwide, and a crucial risk factor is food insecurity. This Review provides an extensive overview of food insecurity in the context of MASLD and discusses potential policies and procedures as interventions.
   Socially deprived communities bear the brunt of the increasing prevalence of liver disease, especially metabolic dysfunction-associated steatotic liver disease (MASLD), which is affected by social nutrition factors.Socioeconomic disparities in liver disease are partially explained by disparities in major hepatic risk factors (for example, unhealthy diet, tobacco use, alcohol consumption and physical inactivity).The unequal challenges in maintaining a healthy diet are related to social and commercial determinants of health, including food insecurity, all of which can be reduced through a systems approach.Liver specialists must address food insecurity and limited availability of accessible and affordable nutritious food, which, coupled with low food literacy and aggressive marketing, lead to over-consumption of low-quality food.To respond to the MASLD burden, the liver community needs to address food insecurity in the community and clinical care settings with 'food is medicine' and a social prescribing approach.Bringing together multiple disciplines, including hepatology, social sciences, mental health and nutrition, with the support of the health system and policy, is needed to address health disparities such as food insecurity.
C1 [Zelber-Sagi, Shira] Univ Haifa, Fac Social Welf & Hlth Sci, Sch Publ Hlth, Haifa, Israel.
   [Zelber-Sagi, Shira; Younossi, Zobair M.; Lazarus, Jeffrey V.] Global NASH Council, Washington, DC 20037 USA.
   [Carrieri, Patrizia] Aix Marseille Univ, Inserm, IRD, SESSTIM,Sci Econ & Sociales Sante & Traitement Inf, Marseille, France.
   [Pericas, Juan M.] Univ Autonoma Barcelona, Vall Dhebron Univ Hosp, Vall Dhebron Inst Res, Liver Unit,CIBERehd, Barcelona, Spain.
   [Pericas, Juan M.] Johns Hopkins Univ Pompeu Fabra Univ Publ Policy C, Barcelona, Spain.
   [Ivancovsky-Wajcman, Dana; Lazarus, Jeffrey V.] Univ Barcelona, Hosp Clin, Barcelona Inst Global Hlth ISGlobal, Barcelona, Spain.
   [Younossi, Zobair M.] Inova Hlth Syst, Beatty Liver & Obes Res Program, Falls Church, VA USA.
   [Lazarus, Jeffrey V.] CUNY Grad Sch Publ Hlth & Hlth Policy SPH, New York, NY USA.
C3 University of Haifa; Institut National de la Sante et de la Recherche
   Medicale (Inserm); Institut de Recherche pour le Developpement (IRD);
   Aix-Marseille Universite; Autonomous University of Barcelona; CIBER -
   Centro de Investigacion Biomedica en Red; CIBEREHD; Hospital
   Universitari Vall d'Hebron; University of Barcelona; Hospital Clinic de
   Barcelona; ISGlobal; Inova Health System
RP Zelber-Sagi, S (corresponding author), Univ Haifa, Fac Social Welf & Hlth Sci, Sch Publ Hlth, Haifa, Israel.; Zelber-Sagi, S (corresponding author), Global NASH Council, Washington, DC 20037 USA.
EM szelber-s@univ.haifa.ac.il
RI Younossi, Zobair M./JRY-9916-2023; Carrieri, Maria
   Patrizia/LZG-7375-2025; Pericàs, Juan/N-5674-2019; Lazarus, Jeffrey
   V./R-6248-2018
OI Pericas, Juan M/0000-0002-3645-3293; Carrieri,
   Patrizia/0000-0002-6794-4837; Lazarus, Jeffrey V./0000-0001-9618-2299
FU Institution: Beatty Liver and Obesity Research Program, Inova Health
   System, Falls Church, Virginia; Global NASH Council, Washington, DC; IS
   Global - MCIN/AEI [CEX2018-000806-S]; Generalitat de Catalunya
FX The authors thank J. M. Paik for performing descriptive analysis with
   visualizations (Figs. 1 and 2). Institution: Beatty Liver and Obesity
   Research Program, Inova Health System, Falls Church, Virginia, The
   Global NASH Council, Washington, DC. This work received no funding.
   D.I.W. and J.V.L. acknowledge support to IS Global from the grant
   CEX2018-000806-S funded by MCIN/AEI/10.13039/501100011033 and the
   Generalitat de Catalunya<acute accent> through the CERCA Programme,
   outside the submitted work.
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NR 226
TC 8
Z9 8
U1 0
U2 4
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 1759-5045
EI 1759-5053
J9 NAT REV GASTRO HEPAT
JI Nat. Rev. Gastroenterol. Hepatol.
PD OCT
PY 2024
VL 21
IS 10
BP 668
EP 686
DI 10.1038/s41575-024-00959-4
EA JUL 2024
PG 19
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA H7F0D
UT WOS:001279232900001
PM 39075288
DA 2025-06-11
ER

PT J
AU Titova, OE
   Baron, JA
   Michaëlsson, K
   Larsson, SC
AF Titova, Olga E.
   Baron, John A.
   Michaelsson, Karl
   Larsson, Susanna C.
TI Anger frequency and risk of cardiovascular morbidity and mortality
SO EUROPEAN HEART JOURNAL OPEN
LA English
DT Article
DE Cardiovascular disease; Cardiovascular mortality; Anger; Sex; Cohort;
   Diabetes
ID CORONARY-HEART-DISEASE; ALL-CAUSE MORTALITY; MYOCARDIAL-INFARCTION;
   ATRIAL-FIBRILLATION; GENDER-DIFFERENCES; FOLLOW-UP; HOSTILITY;
   EXPRESSION; DEPRESSION; CORTISOL
AB Aims Anger may increase the risk of cardiovascular diseases (CVDs) but previous findings are inconclusive and large prospective studies are needed. We investigated whether frequency of strong anger is associated with the incidence of specific CVDs and CVD mortality, and if sex, age, and cardiometabolic risk factors modify these associations.Methods and results We used data from a population-based cohort of 47 077 Swedish adults (56-94 years of age) who completed questionnaires regarding their experience of anger, lifestyle habits, and health characteristics. Participants were followed for incident cardiovascular outcomes and death up to 9 years through linkage to the Swedish National Patient and Death Registers. Hazard ratios and confidence intervals adjusted for potential confounders were assessed. In multivariable analyses, frequent episodes of strong anger were associated with an increased risk of heart failure, atrial fibrillation, and CVD mortality [hazard ratios (95% confidence intervals) = 1.19 (1.04-1.37), 1.16 (1.06-1.28), and 1.23 (1.09-1.40), respectively]. The link between anger frequency and heart failure was more pronounced in men and participants with a history of diabetes. No evidence of an independent association of anger frequency with risk of myocardial infarction, aortic valve stenosis, and abdominal aortic aneurysm was found.Methods and results We used data from a population-based cohort of 47 077 Swedish adults (56-94 years of age) who completed questionnaires regarding their experience of anger, lifestyle habits, and health characteristics. Participants were followed for incident cardiovascular outcomes and death up to 9 years through linkage to the Swedish National Patient and Death Registers. Hazard ratios and confidence intervals adjusted for potential confounders were assessed. In multivariable analyses, frequent episodes of strong anger were associated with an increased risk of heart failure, atrial fibrillation, and CVD mortality [hazard ratios (95% confidence intervals) = 1.19 (1.04-1.37), 1.16 (1.06-1.28), and 1.23 (1.09-1.40), respectively]. The link between anger frequency and heart failure was more pronounced in men and participants with a history of diabetes. No evidence of an independent association of anger frequency with risk of myocardial infarction, aortic valve stenosis, and abdominal aortic aneurysm was found.Conclusion Our findings indicate that anger may contribute to the development of specific CVDs and CVD mortality, especially heart failure in men and in those with diabetes.
C1 [Titova, Olga E.; Baron, John A.; Michaelsson, Karl; Larsson, Susanna C.] Uppsala Univ, Dept Surg Sci, Unit Med Epidemiol, Uppsala, Sweden.
   [Baron, John A.] Univ North Carolina, Dept Med, Sch Med, Chapel Hill, NC USA.
   [Baron, John A.] Univ North Carolina, Gillings Sch Global Publ Hlth, Dept Epidemiol, Chapel Hill, NC USA.
   [Larsson, Susanna C.] Karolinska Inst, Inst Environm Med, Unit Cardiovasc & Nutr Epidemiol, Stockholm, Sweden.
C3 Uppsala University; University of North Carolina; University of North
   Carolina Chapel Hill; University of North Carolina School of Medicine;
   University of North Carolina; University of North Carolina Chapel Hill;
   Karolinska Institutet
RP Titova, OE; Larsson, SC (corresponding author), Uppsala Univ, Dept Surg Sci, Unit Med Epidemiol, Uppsala, Sweden.; Larsson, SC (corresponding author), Karolinska Inst, Inst Environm Med, Unit Cardiovasc & Nutr Epidemiol, Stockholm, Sweden.
EM olga.titova@surgsci.uu.se; susanna.larsson@surgsci.uu.se
RI Larsson, Susanna/F-6065-2015; Michaelsson, Karl/AAM-9094-2021; Titova,
   Olga E/AAC-4101-2019
OI Larsson, Susanna/0000-0003-0118-0341; Michaelsson,
   Karl/0000-0003-2815-1217; Titova, Olga E/0000-0003-2747-1606
FU Ragna Foundation [SIMP2019004]; Uppsala Multidisciplinary Center for
   Advanced Computational Science (UPPMAX)
FX The authors thank the national research infrastructure SIMPLER for
   provisioning of facilities and experimental support. The computations
   were performed on resources provided by the Swedish National
   Infrastructure for Computing (www.snic.se) support for sensitive data
   SNIC-SENS through the Uppsala Multidisciplinary Center for Advanced
   Computational Science (UPPMAX) under Project SIMP2019004.
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NR 47
TC 9
Z9 9
U1 0
U2 1
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
EI 2752-4191
J9 EUR HEART J OPEN
JI Eur. Heart J. Open
PD JUL
PY 2022
VL 2
IS 4
AR oeac050
DI 10.1093/ehjopen/oeac050
PG 8
WC Cardiac & Cardiovascular Systems
WE Emerging Sources Citation Index (ESCI)
SC Cardiovascular System & Cardiology
GA 1RW9U
UT WOS:001472193900007
PM 36117950
OA Green Published
DA 2025-06-11
ER

PT J
AU Li, L
   Pereira, SMP
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AF Li, Leah
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TI Childhood maltreatment and biomarkers for cardiometabolic disease in
   mid-adulthood in a prospective British birth cohort: associations and
   potential explanations
SO BMJ OPEN
LA English
DT Article
ID CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; SCIENTIFIC STATEMENT;
   MULTIPLE IMPUTATION; MEDIATION ANALYSIS; BLOOD-PRESSURE; MENTAL-HEALTH;
   HEART-DISEASE; SEXUAL-ABUSE; LOW-DENSITY
AB Objectives Research on associations between childhood maltreatment and adult cardiometabolic disease risk is sparse. We aimed to investigate associations between different forms of child maltreatment and mid-adult cardiometabolic markers and whether potential intermediaries could account for the associations observed.
   Setting 1958 British birth cohort.
   Participants Approximately 9000 cohort members with data on cardiometabolic markers.
   Outcomes Adult (45y) cardiometabolic markers (blood pressure, lipids and glycated haemoglobin [HbA(1c)]).
   Results Seventeen per cent of participants were identified as neglected; 6.1%, 1.6% and 10.0% were identified as experiencing physical, sexual and psychological abuse, respectively. Childhood neglect and physical abuse were associated with high body mass index (BMI) and large waist circumference when adjusting for early-life covariates. For neglect, the adjusted odds ratio (AOR) was 1.16 (95% CI: 1.02 to 1.32) and 1.15 (1.02 to 1.30) for general and central obesity, respectively, and for physical abuse, the respective AOR was 1.36 (1.13 to 1.64) and 1.38 (1.16 to 1.65). Neglect was also associated with raised triglycerides by 3.9 (0.3 to 7.5)% and HbA(1c) by 1.2 (0.4 to 2.0)%, and among females, lower high-density lipoprotein cholesterol (HDL-c) by 0.05 (0.01 to 0.08) mmol/L after adjustment. For physical abuse, the AOR was 1.25 (1.00 to 1.56) for high low-density lipoprotein cholesterol, HbA(1c) was raised by 2.5 (0.7 to 4.3)% (in males) and HDL-c was lower by 0.06 (0.01 to 0.12) mmol/L (in females). Associations for sexual abuse were similar to those for physical abuse but 95% CIs were wide. For psychological abuse, the AOR for elevated triglycerides was 1.21 (1.02 to 1.44) and HDL-c was lower by 0.04 (0.01 to 0.07) mmol/L. Maltreatments were not associated with raised blood pressure. In analyses of potential intermediary factors, several associations attenuated after adjustment for adult lifestyles (mainly smoking and alcohol consumption rather than physical activity) and child-to-adult BMI.
   Conclusions Childhood maltreatments, particularly neglect and physical abuse, were associated with greater adiposity and poorer lipid and HbA(1c) profiles decades later in adulthood. Associations were modest but independent of early-life factors linked to these outcomes. Findings implicate adult lifestyles as an important intermediary between child maltreatment and outcomes.
C1 [Li, Leah; Pereira, Snehal M. Pinto; Power, Christine] UCL, Populat Policy & Practice Programme, Great Ormond St Inst Child Hlth, London, England.
C3 University of London; University College London
RP Li, L (corresponding author), UCL, Populat Policy & Practice Programme, Great Ormond St Inst Child Hlth, London, England.
EM leah.li@ucl.ac.uk
RI Pereira, Snehal/F-9444-2011
OI Pinto Pereira, Snehal/0000-0002-0876-8757; Li, Leah/0000-0002-3603-6457
FU Department of Health Policy Research Programme through the Public Health
   Research Consortium (PHRC); National Institute for Health Research
   Biomedical Research Centre at Great Ormond Street Hospital for Children
   NHS Foundation Trust and University College London; Medical Research
   Council [G0000934]
FX This work was funded by the Department of Health Policy Research
   Programme through the Public Health Research Consortium (PHRC) and
   supported by the National Institute for Health Research Biomedical
   Research Centre at Great Ormond Street Hospital for Children NHS
   Foundation Trust and University College London. The views expressed in
   the publication are those of the authors and not necessarily those of
   the Department of Health. Information about the wider programme of the
   PHRC is available at http://phrc.lshtm.ac.uk. Data collection for
   participants at age 45 was funded by the Medical Research Council, grant
   G0000934. The authors are grateful to the Centre for Longitudinal
   Studies (CLS), University College London Institute of Education for the
   use of these data and the UK Data Service for making them available.
   However, neither CLS nor the UK Data Service bears any responsibility
   for the analysis or interpretation of these data.
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NR 61
TC 33
Z9 33
U1 0
U2 11
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2044-6055
J9 BMJ OPEN
JI BMJ Open
PD JUN
PY 2019
VL 9
IS 3
AR e024079
DI 10.1136/bmjopen-2018-024079
PG 11
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA IC7HO
UT WOS:000471144900104
PM 30904846
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Villarini, A
   Pasanisi, P
   Traina, A
   Mano, MP
   Bonanni, B
   Panico, S
   Scipioni, C
   Galasso, R
   Paduos, A
   Simeoni, M
   Bellotti, E
   Barbero, M
   Macellari, G
   Venturelli, E
   Raimondi, M
   Bruno, E
   Gargano, G
   Fornaciari, G
   Morelli, D
   Seregni, E
   Krogh, V
   Berrino, F
AF Villarini, Anna
   Pasanisi, Patrizia
   Traina, Adele
   Mano, Maria Piera
   Bonanni, Bernardo
   Panico, Salvatore
   Scipioni, Corrado
   Galasso, Rocco
   Paduos, Adriana
   Simeoni, Milena
   Bellotti, Elena
   Barbero, Maggiorino
   Macellari, Giorgio
   Venturelli, Elisabetta
   Raimondi, Milena
   Bruno, Eleonora
   Gargano, Giuliana
   Fornaciari, Giuseppe
   Morelli, Daniele
   Seregni, Ettore
   Krogh, Vittorio
   Berrino, Franco
TI Lifestyle and breast cancer recurrences: The DIANA-5 trial
SO TUMORI JOURNAL
LA English
DT Article
DE breast cancer; diet; physical exercise; randomized trial; recurrence;
   survival
ID GROWTH-FACTOR-I; TRADITIONAL MEDITERRANEAN DIET; SERUM SEX STEROIDS;
   POSTMENOPAUSAL WOMEN; PHYSICAL-ACTIVITY; METABOLIC SYNDROME;
   HORMONE-LEVELS; PREMENOPAUSAL WOMEN; PLASMA ADIPONECTIN; HOSPITAL
   ANXIETY
AB Aims and background. The DIANA (Diet and Androgens)-5 study is a multi-institutional randomized controlled trial of the effectiveness of a diet based on Mediterranean and macrobiotic recipes and principles, associated with moderate physical activity, in reducing additional breast cancer events in women with early stage invasive breast cancer at high risk of recurrence because of metabolic or endocrine milieu. The intervention is expected to reduce serum insulin and sex hormones, which were associated with breast prognosis in previous studies.
   Methods. Between 2008 and 2010, the study randomly assigned 1208 patients to an intensive diet and exercise intervention or to a comparison group, to be followed-up through 2015. General lifestyle recommendations for the prevention of cancer are given to both groups, and the intervention group is being offered a comprehensive lifestyle intervention, including cooking classes, conferences, common meals and exercise sessions. Adherence assessments occurred at baseline and at 12 months and are planned at 36 and 60 months. They include food frequency diaries, anthropometric measures, body fat distribution assessed with impedance scale, one week registration of physical activity with a multisensor arm-band monitor, metabolic and endocrine blood parameters. Outcome breast cancer events are assessed through self report at semi annual meetings or telephone interview and are validated through medical record verification.
   Results. The randomized groups were comparable for age (51.8 years), proportion of ER-negative tumors (22%), axillary node metastasis (42%), reproductive variables, tobacco smoking, blood pressure, anthropometric measurements and hormonal and metabolic parameters.
   Conclusions. DIANA-5 has the potential to establish whether a Mediterranean-macrobiotic lifestyle may reduce breast cancer recurrences. We will assess evidence of effectiveness, first by comparing the incidence of additional breast cancer events (local or distant recurrence, second ipsilateral or contralateral cancer) in the intervention and in the control group, by an intention-to-treat analysis, and second by analyzing the incidence of breast cancer events in the total study population by compliance assessment score.
C1 [Villarini, Anna; Pasanisi, Patrizia; Venturelli, Elisabetta; Raimondi, Milena; Bruno, Eleonora; Gargano, Giuliana; Fornaciari, Giuseppe; Krogh, Vittorio; Berrino, Franco] Fdn IRCCS Ist Nazl Tumori, Dept Predict & Prevent Med, I-20133 Milan, Italy.
   [Traina, Adele] ARNAS Osped Civ & Benfratelli G Di Cristina & M A, Dept Oncol, Palermo, Italy.
   [Mano, Maria Piera] Ctr Riferimento Epidemiol & Prevenz Oncol Piemont, Turin, Italy.
   [Bonanni, Bernardo] European Inst Oncol, Milan, Italy.
   [Panico, Salvatore] Univ Naples Federico II, Dept Clin & Expt Med, Naples, Italy.
   [Scipioni, Corrado] Ctr Prevenz Diag & Terapia Tumore Mammella Giunon, Laquila, Italy.
   [Galasso, Rocco] Ctr Riferimento Oncol, Dept Oncol, Potenza, Italy.
   [Paduos, Adriana] Osped Inferm Biella, GIC Senol, Biella, Italy.
   [Simeoni, Milena] Assoc LUMEN, San Pietro In Cerro, Piacenza, Italy.
   [Bellotti, Elena] Azienda Osped Busto Arsizio Varese, Radiol Unit, Varese, Italy.
   [Barbero, Maggiorino] Osped Cardinal Massai, SOC Ginecol & Ostetricia, Asti, Italy.
   [Macellari, Giorgio] Azienda Sanit Locale, Unit Senol, Piacenza, Italy.
   [Morelli, Daniele] Fdn IRCCS Ist Nazl Tumori, Dept Pathol & Lab Med, Milan, Italy.
   [Seregni, Ettore] Fdn IRCCS Ist Nazl Tumori, Dept Diagnost Imaging & Radiotherapy, Milan, Italy.
C3 Fondazione IRCCS Istituto Nazionale Tumori Milan; IRCCS European
   Institute of Oncology (IEO); University of Naples Federico II; Ospedale
   di Busto Arsizio; Fondazione IRCCS Istituto Nazionale Tumori Milan;
   Fondazione IRCCS Istituto Nazionale Tumori Milan
RP Berrino, F (corresponding author), Fdn IRCCS Ist Nazl Tumori, Dept Predict & Prevent Med, Via Venezian 1, I-20133 Milan, Italy.
EM franco.berrino@istitutotumori.mi.it
RI Bonanni, Bernardo/AAM-7928-2020; Panico, Salvatore/K-6506-2016; Berrino,
   Franco/AAC-2364-2020; Gargano, Giuliana/Q-4497-2019; canete,
   adela/G-5903-2016; Krogh, Vittorio/AAA-9171-2019; Morelli,
   Daniele/I-4113-2017; Villarini, Anna/K-2838-2017; Krogh,
   Vittorio/K-2628-2016; Venturelli, Elisabetta/B-8790-2017; Seregni,
   Ettore/C-2597-2017; bruno, eleonora/D-4093-2017; Pasanisi,
   Patrizia/F-4908-2017; Galasso, Rocco/AAL-2150-2020
OI Morelli, Daniele/0000-0002-1823-3764; Villarini,
   Anna/0000-0002-5789-6587; Krogh, Vittorio/0000-0003-0122-8624; Berrino,
   Franco/0000-0002-4858-1866; MARIA PIERA, MANO/0000-0002-0987-9299;
   Venturelli, Elisabetta/0000-0002-7427-7032; Panico,
   Salvatore/0000-0002-5498-8312; Seregni, Ettore/0000-0002-5097-049X;
   bruno, eleonora/0000-0002-9605-9482; Pasanisi,
   Patrizia/0000-0001-6278-3491; Galasso, Rocco/0000-0003-4831-6437;
   Gargano, Giuliana/0000-0002-0813-3022
FU Italian Association for Cancer Research (AIRC) [11942]; Italian
   Department of Health (PIO); Lega Vita Salute; Regione Sicilia;
   Fondazione Edo Tempia; Susan G Komen Italia
FX The study was financed by the Italian Association for Cancer Research
   (AIRC, Grant no 11942) and by the Italian Department of Health (PIO
   program). Lega Vita & Salute, Regione Sicilia, Fondazione Edo Tempia and
   Susan G Komen Italia also supported the study.
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NR 123
TC 88
Z9 92
U1 2
U2 46
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0300-8916
EI 2038-2529
J9 TUMORI J
JI Tumori J.
PD JAN-FEB
PY 2012
VL 98
IS 1
BP 1
EP 18
PG 18
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA 922BF
UT WOS:000302521100002
PM 22495696
DA 2025-06-11
ER

PT J
AU Del Bosque-plata, L
   Amin, M
   Wu, R
   Postolache, TT
   Gragnoli, C
AF Del Bosque-plata, L.
   Amin, M.
   Wu, R.
   Postolache, T. T.
   Gragnoli, C.
TI Novel TCF7L2 familial linkage and association with Type 2 diabetes,
   depression, and their comorbidity
SO EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
LA English
DT Article
DE Major depressive disorder; MDD; Depression; Type 2 diabetes; T2D;
   Transcription factor 7-like 2; Linkage; Linkage disequilibrium; LD;
   Asso-ciation; LD block; Comorbid; Mental-metabolic co-morbidity;
   Pleiotropy; Gene; Variant; Single nucle-otide polymorphism; SNP;
   Italian; Families; Schizo-phrenia; SCZ; Bipolar disorder; Microarray;
   PLINK; Pseudomarker; recessive; Dominant; model; Com-plete penetrance;
   Incomplete penetrance; In sili-co analysis; Tuscany; Independent; MRNA;
   Expres-sion; Wnt signaling pathway; DSM-IV criteria; Intron-ic;
   Rs10885398; Rs11196181; Rs7903146; Rs11592706; Rs74825300; Rs4918788;
   Rs7919409; Rs12255179; Rs79805154; Rs3814572; Rs75351685; Rs7084875;
   Rs176632; Rs10885401; Rs7904519; Rs10787472; Rs77795162; Rs61872787;
   Rs61872794; Rs6585205; Rs6585206; Rs7081841; Rs112775103; CCAAT;
   En-hancer-Binding Protein ?; C; EBP?; Lipid; Glucose metabolism;
   Triglycerides; Insulin resistance; Tran-scription factor; TF; Binding
   site; Organic cation-up-take transporter; OCT1; Type 1 diabetes; T1D;
   Obe-sity; Gestational diabetes; GD; Metabolic syndrome; MetS; Diabetic
   nephropathy; Cancer; Cystic fibrosis; CF; Premature adrenarche;
   Polycystic ovarian syn-drome; PCOS; Cardiovascular disease; CVD;
   Coro-nary artery disease; CAD; Schizoid disorders; Effect; Neurogenesis;
   Oligodendrogenesis; Thalamocortical circuitry; Habenula; Developmental
   events; Molecu-lar neuron diversification; Prosomere 2; In vivo;
   Ven-tral habenula formation; Functional activity; Ventral habenular
   neurons; Lateralized fate selection; Alter-native pathways; major neural
   circuit asymmetries; Disintegration; Left thalamus; Right habenula tract
   function; Compensational mechanism; Familial study; Italy; Novel; Risk;
   First; Replicate; Ethnic groups; Role; ?-Catenin; Pathway; Drug
   development
ID GENETIC-VARIANTS; PROSTATE-CANCER; ATHEROSCLEROSIS RISK; BIPOLAR
   DISORDER
AB OBJECTIVE: Alterations in the activity of the transcription factor 7-like 2 (TC-F7L2) generate defects previously associated with neuropsychiatric disorders. We investigat-ed the role of the TCF7L2 gene in major depres-sive disorder (MDD), type 2 diabetes (T2D), and MDD-T2D comorbidity. We tested whether TC-F7L2 is in linkage to and/or in linkage disequi-librium (LD, namely association) with MDD, T2D, and MDD-T2D.PATIENTS AND METHODS: In 212 families with T2D and MDD in the Italian population, we analyzed 80 microarray-based SNPs using Pseudomarker software for linkage to and LD with T2D and MDD under the recessive model with complete penetrance (R1). In a secondary analysis, we tested the variants under the dom-inant models with complete penetrance (D1), re-cessive with incomplete penetrance (R2), and recessive with incomplete penetrance (R2). RESULTS: We found several novel linkage sig-nals and genetic associations. In addition, we found two new transcription-factor (TF) bind-ing sites created by two risk variants found: the MDD-risk variant rs12255179 creates a new TF-binding site for the CCAAT/enhancer-bind-ing protein alpha (C/EBP alpha), and the T2D-risk variant rs61872794 creates a new TF-binding site for the organic cation-uptake transporter (OCT1). Both new binding sites are related to insulin metab-olism.CONCLUSIONS: These results highlight the cross-interactivity between T2D and MDD. Fur-ther replication is needed in diverse ethnic groups.
C1 [Del Bosque-plata, L.] Natl Inst Genom Med, Nutrigenet & Nutrigen Lab, Mexico City, Mexico.
   [Amin, M.] INSERM, Us 14 Orphanet, Paris, France.
   [Amin, M.] Univ Paris, Paris, France.
   [Amin, M.] Al Neelain Univ, Fac Med, Dept Biochem & Mol Biol, Khartoum, Sudan.
   [Wu, R.; Gragnoli, C.] Penn State Coll Med, Dept Publ Hlth Sci, Hershey, PA 17033 USA.
   [Wu, R.] Penn State Coll Med, Dept Stat, Hershey, PA USA.
   [Postolache, T. T.] Univ Maryland, Sch Med, Dept Psychiat, Mood & Anxiety Program, Baltimore, MD USA.
   [Postolache, T. T.] Rocky Mt Mental Illness Res Educ & Clin Ctr MIRECC, Vet Integrated Serv Network VISN 19, Mil & Vet Microbiome Consortium Res & Educ MVM CoR, Denver, CO USA.
   [Postolache, T. T.] VA Capitol Hlth Care Network, Vet Integrated Serv Network VISN 5, Mental Illness Res Educ & Clin Ctr MIRECC, Baltimore, MD USA.
   [Gragnoli, C.] Creighton Univ, Sch Med, Dept Med, Div Endocrinol, Omaha, NE 68124 USA.
   [Gragnoli, C.] Bios Biotech Multidiagnost Hlth Ctr, Mol Biol Lab, Rome, Italy.
C3 Instituto Nacional de Medicina Genomica; Institut National de la Sante
   et de la Recherche Medicale (Inserm); Universite Paris Cite;
   Pennsylvania Commonwealth System of Higher Education (PCSHE);
   Pennsylvania State University; Penn State Health; Pennsylvania
   Commonwealth System of Higher Education (PCSHE); Pennsylvania State
   University; Penn State Health; University System of Maryland; University
   of Maryland Baltimore; Creighton University
RP Gragnoli, C (corresponding author), Penn State Coll Med, Dept Publ Hlth Sci, Hershey, PA 17033 USA.; Gragnoli, C (corresponding author), Creighton Univ, Sch Med, Dept Med, Div Endocrinol, Omaha, NE 68124 USA.; Gragnoli, C (corresponding author), Bios Biotech Multidiagnost Hlth Ctr, Mol Biol Lab, Rome, Italy.
EM claudia.gragnoli@gmail.com
RI Gragnoli, Claudia/ABA-4841-2020
FU Creighton University School of Medicine, through the Nebraska Department
   of Health and Human Services (DHHS)
FX This publication was supported in part with the funds received under
   Nebraska Laws 2021, LB 380, Section 109 awarded to C.G. (PI) , Creighton
   University School of Medicine, through the Nebraska Department of Health
   and Human Services (DHHS) . Its contents represent the views of the
   authors and do not necessarily represent the official views of the State
   of Nebraska or DHHS.
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NR 62
TC 3
Z9 3
U1 1
U2 12
PU VERDUCI PUBLISHER
PI ROME
PA VIA GREGORIO VII, ROME, 186-00165, ITALY
SN 1128-3602
J9 EUR REV MED PHARMACO
JI Eur. Rev. Med. Pharmacol. Sci.
PY 2023
VL 27
IS 2
BP 694
EP 703
PG 10
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 8Z7VP
UT WOS:000933582100017
PM 36734726
DA 2025-06-11
ER

PT J
AU Gordon, CJ
   Phillips, PM
   Johnstone, AFM
AF Gordon, C. J.
   Phillips, P. M.
   Johnstone, A. F. M.
TI Impact of genetic strain on body fat loss, food consumption, metabolism,
   ventilation, and motor activity in free running female rats
SO PHYSIOLOGY & BEHAVIOR
LA English
DT Article
DE Exercise; Genetic strain; Body composition; Metabolism; Running wheel;
   Food consumption
ID BROWN-NORWAY RATS; ESTROUS-CYCLE; SEX-DIFFERENCES; OLETF RATS; WHEEL;
   EXERCISE; TEMPERATURE; AGE; INTENSITY; ANXIETY
AB Chronic exercise is considered as one of the most effective means of countering symptoms of the metabolic syndrome (MS) such as obesity and hyperglycemia. Rodent models of forced or voluntary exercise are often used to study the mechanisms of MS and type 2 diabetes. However, there is little known on the impact of genetic strain on the metabolic response to exercise. We studied the effects of housing rats with running wheels (RW) for 65 days-compared to sedentary (SED) housing in five female rat strains: Sprague-Dawley (SD), Long-Evans (LE), Wistar (WIS), spontaneously hypertensive (SHR), and Wistar-Kyoto (WKY). Key parameters measured were total distance run, body composition, food consumption, motor activity, ventilatory responses by plethysmography, and resting metabolic rate (MR). WKY and SHR ran significantly more than the WIS, LE, and SD strains. Running-induced reduction in body fat was affected by strain but not by distance run. LE's lost 6% fat after 21 d of running whereas WKY's lost 2% fat but ran 40% more than LE's. LE and WIS lost body weight while the SHR and WKY strains gained weight during running. Food intake with RW was markedly increased in SHR, WIS, and WKY while LE and SD showed modest increases. Exploratory motor activity was reduced sharply by RW in all but the SD strain. Ventilatory parameters were primarily altered by RW in the SHR, WKY, and WIS strains. MR was unaffected by RW. In an overall ranking of physiological and behavioral responses to RW, the SD strain Was considered the least responsive whereas the WIS was scored as most responsive. In terms of RW-induced fat loss, the LE strain appears to be the most ideal. These results should be useful in the future selection of rat models to study benefits of volitional exercise. Published by Elsevier Inc.
C1 [Gordon, C. J.; Phillips, P. M.; Johnstone, A. F. M.] US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Tox Assessment Div, Res Triangle Pk, NC 27711 USA.
C3 United States Environmental Protection Agency
RP Gordon, CJ (corresponding author), US EPA, 109 TW Alexander Dr, Res Triangle Pk, NC 27711 USA.
EM Gordon.christopher@epa.gov
RI Gordon, Christopher/KVB-4813-2024
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NR 25
TC 15
Z9 17
U1 0
U2 20
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0031-9384
J9 PHYSIOL BEHAV
JI Physiol. Behav.
PD JAN 1
PY 2016
VL 153
BP 56
EP 63
DI 10.1016/j.physbeh.2015.10.025
PG 8
WC Psychology, Biological; Behavioral Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Behavioral Sciences
GA CZ0AP
UT WOS:000366767800008
PM 26597120
DA 2025-06-11
ER

PT J
AU Moreno, O
   Meoro, A
   Martinez, A
   Rodriguez, C
   Pardo, C
   Aznar, S
   Lopez, P
   Serrano, J
   Boix, E
   Martin, MD
   Alfonso, AMP
AF Moreno, O.
   Meoro, A.
   Martinez, A.
   Rodriguez, C.
   Pardo, C.
   Aznar, S.
   Lopez, P.
   Serrano, J.
   Boix, E.
   Martin, M. D.
   Alfonso, A. M. Pico
TI Comparison of two low-calorie diets: A prospective study of
   effectiveness and safety
SO JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
LA English
DT Article
DE obesity; body mass index; low-calorie diet; cost-effective; metabolic
   syndrome
ID INSULIN-RESISTANCE; OBESE-PATIENTS; WEIGHT-LOSS; MORTALITY; OVERWEIGHT;
   THERAPY; COHORT; IMPACT; INDEX
AB Objective: To evaluate the cost-effectiveness and safety of two distinct low calorie diets (LCD). Design: Prospective controlled study. Methods: 67 obese patients [body mass index (BMI) 40 kg/m(2)] were included in two study groups. Group A: 26 patients followed a 458 kcal diet given in three meals for 1 month. Group B: 41 patients followed a 800 kcal diet for 3 months and with outpatient control. Measurements: Anthropometric, cardiovascular risk and nutritional profile changes were evaluated, as well as total direct and indirect costs, and the incidence of complications. Results: No significant initial differences were observed between the two study groups. Eighty-six point two per cent of the patients completed the therapy correctly. After treatment a significant decrease was observed in the following variables for both groups, but no differences were detected between Groups A and B: mean weight loss (A = 9.28 kg, B = 8.7 kg), ponderal loss percentage (A/B = 7.2/6.8%), glycemia (A/B = 18.6/12.1 mg/dl), systolic blood pressure (SBP) (A/B = 11.8/6.5 mmHg), diastolic blood pressure (DBP) (A/B 5.9/6.8 mmHg), and final insulin-resistance (IR) index (A = 4.4, B = 4.3). Group A had the highest drop in total cholesterol (37.7 vs 8.1 mg/dl) and triglycerides (54.4 vs 2.5 mg/dl). No changes were observed in ureic acid, renal function and serum albumin. Thirty-six patients (55.3%) suffered trivial complications associated to the VLCD (16.9% gastrointestinal, 20% anxiety), with no differences between groups. Group A patients were on sick leave due to asthenia, and two patients in this group had serious complications (transient ischemic attack and atrial fibrillation). The total cost of Group A treatment was 3018.9 against 582.6 euros for Group B. Conclusions: The 3-month 800 kcal/day VLCD was more cost-effective and safer than the 1-month 458 kcal/day diet.
C1 Alicante Gen Univ Hosp, Endocrinol & Nutr Sect, Alicante, Spain.
C3 General University Hospital of Alicante
RP Moreno, O (corresponding author), Alicante Gen Univ Hosp, Endocrinol & Nutr Sect, C Pintor Baeza 12, Alicante, Spain.
EM oscarmorenop76@hotmail.com
RI pico, antonio/E-9061-2011; PICO, ANTONIO/B-6439-2018; Moreno-Perez,
   Oscar/F-4556-2016
OI PICO, ANTONIO/0000-0002-7549-7563; Moreno-Perez,
   Oscar/0000-0002-8670-6404
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NR 34
TC 10
Z9 10
U1 0
U2 4
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0391-4097
EI 1720-8386
J9 J ENDOCRINOL INVEST
JI J. Endocrinol. Invest.
PD JUL-AUG
PY 2006
VL 29
IS 7
BP 633
EP 640
DI 10.1007/BF03344163
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 086IT
UT WOS:000240667700009
PM 16957412
DA 2025-06-11
ER

PT J
AU Aljefri, YE
   Alahmadi, RA
   Alajmi, RS
   Alkhamisi, TA
   Maaddawi, HA
   Alraddadi, AA
   Alamri, AM
AF Aljefri, Yara E.
   Alahmadi, Rana A.
   Alajmi, Rakan S.
   Alkhamisi, Taif A.
   Maaddawi, Hadeel A.
   Alraddadi, Ali A.
   Alamri, Awadh M.
TI Cutaneous Manifestations and Hormonal Changes Among Polycystic Ovary
   Syndrome Patients at a Tertiary Care Center
SO CUREUS JOURNAL OF MEDICAL SCIENCE
LA English
DT Article
DE referral pattern; medical comorbidities; hormone levels; cutaneous
   manifestations; polycystic ovary syndrome (pros)
ID METABOLIC SYNDROME; WOMEN; ASSOCIATIONS; PREVALENCE; FEATURES; ANXIETY;
   RISK
AB Background: Polycystic ovary syndrome (PCOS) is a highly prevalent endocrine disorder affecting 5%-10% of women worldwide. PCOS patients usually present with cutaneous manifestations of hyperandrogenism, such as acne, hirsutism, and androgenic alopecia.
   Objective: To estimate the prevalence of dermatological manifestations and their association with hormonal changes in PCOS patients. In addition, this study aimed to estimate the prevalence of comorbidities associated with PCOS and to demonstrate the referral pattern among Dermatology, Gynecology, and Primary Health Care (PHC).
   Methods: This is a cross-sectional study conducted at King Abdulaziz Medical City (KAMC) in Jeddah, Saudi Arabia. All PCOS patients who attended KAMC from 2016 to 2021 were included. Data were collected through a retrospective chart review of the electronic medical record system (BestCare) and by utilizing a structured data collection sheet.
   Results: A total of 447 female patients were diagnosed with PCOS with a median age of 29 years and a median BMI of 28.76 kg/m(2).The prevalence of cutaneous manifestations among patients was 68%. H irsut ism (47.3%), acne vulgaris (40.6%), and androgenic alopecia (20.3%) were the most common manifestations. The most common hormonal abnormalities were raised luteinizing hormone (LH) levels in 220 (49.1%) patients and raised LH/follicle-stimulating hormone (FSH) ratio in 159 (35.5%) patients. FSH, LH/FSH ratio, and age were significant predictors for acne vulgaris (P.-value-0.01, 0.04, and 0.01, respectively). Obesity (44.20%), infertility (25.70%), and dyslipidemia (17%) were the most common comorbidities in our sample. Most patients' first visits and follow-ups were in PH(:.
   Conclusion: The prevalence of cutaneous manifestations among PCOS patients is relatively high and plays a significant role in making the diagnosis. Therefore, physicians across multiple specialties need to be more aware of the full spectrum of PCOS presentations to alleviate it from its under-diagnosed status.
C1 [Aljefri, Yara E.; Alahmadi, Rana A.; Alajmi, Rakan S.; Alkhamisi, Taif A.; Maaddawi, Hadeel A.] King Saud Bin Abdulaziz Univ Hlth Sci, Coll Med, Med, Jeddah, Saudi Arabia.
   [Aljefri, Yara E.] King Abdullah Int Med Res Ctr, Coll Med, Jeddah, Saudi Arabia.
   [Alraddadi, Ali A.; Alamri, Awadh M.] King Abdul Aziz Med City, Dept Dermatol, Jeddah, Saudi Arabia.
C3 King Saud Bin Abdulaziz University for Health Sciences; King Saud Bin
   Abdulaziz University for Health Sciences; King Abdulaziz Medical City -
   Jeddah
RP Aljefri, YE (corresponding author), King Saud Bin Abdulaziz Univ Hlth Sci, Coll Med, Med, Jeddah, Saudi Arabia.
EM yaraaljefri11@gmail.com
RI Alahmadi, Rana/MCX-4511-2025
FU King Saud bin Abdul-Aziz University for Health Sciences College of
   Medicine, Jeddah (KSAUHS, COM-J)
FX We would like to acknowledge the research unit at King Saud bin
   Abdul-Aziz University for Health Sciences College of Medicine, Jeddah
   (KSAUHS, COM-J), for their support.
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NR 34
TC 8
Z9 8
U1 0
U2 2
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
EI 2168-8184
J9 CUREUS J MED SCIENCE
JI Cureus J Med Sci
PD DEC 22
PY 2021
VL 13
IS 12
AR e20593
DI 10.7759/cureus.20593
PG 11
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA XX2RH
UT WOS:000736149200004
PM 35103169
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Panagiotopoulos, C
   Ronsley, R
   Al-Dubayee, M
   Brant, R
   Kuzeljevic, B
   Rurak, E
   Cristall, A
   Marks, G
   Sneddon, P
   Hinchliffe, M
   Chanoine, JP
   Mâsse, LC
AF Panagiotopoulos, Constadina
   Ronsley, Rebecca
   Al-Dubayee, Mohammed
   Brant, Rollin
   Kuzeljevic, Boris
   Rurak, Erin
   Cristall, Arlene
   Marks, Glynis
   Sneddon, Penny
   Hinchliffe, Mary
   Chanoine, Jean-Pierre
   Masse, Louise C.
TI The Centre for Healthy Weights-Shapedown BC: A Family-Centered,
   Multidisciplinary Program that Reduces Weight Gain in Obese Children
   over the Short-Term
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Article
DE obesity; weight loss; BMI reduction; children; prevention; treatment;
   intervention
ID PHYSICAL-ACTIVITY QUESTIONNAIRE; 3RD NATIONAL-HEALTH; BODY-MASS INDEX;
   WAIST CIRCUMFERENCE PERCENTILES; INCIDENT CARDIOVASCULAR-DISEASE;
   METABOLIC SYNDROME; INSULIN-RESISTANCE; PSYCHIATRIC-DISORDERS;
   OVERWEIGHT CHILDREN; MANAGEMENT PROGRAM
AB The objective was to conduct a program evaluation of the Centre for Healthy Weights-Shapedown BC (CHW-SB), a family-centered, multidisciplinary program for obese children, by assessing the change in weight trajectories from program intake to completion. Secondary outcomes included changes in clinical, biochemical and psychological parameters, and in physical activity (PA) levels. The CHW-SB program was evaluated over 10 weeks. Data collection included anthropometric, metabolic, PA and psychological measures. Longitudinal mixed effects regression was performed to evaluate weight change from Phase 1 (before program on waitlist) to Phase 2 (during program). 238 children <18 years of age were referred to the program of which 119 were eligible for participation. There was a significant decrease in weight trajectory in children following program entry. Participants experienced an average .89% monthly increase before program entry, compared to a .37% monthly decline afterwards, a drop of 1.26% (p < 0.0001, 95%CI 1.08 to 1.44). zBMI (2.26 +/- 0.33 to 2.20 +/- 0.36, p < 0.001), waist circumference (99 +/- 15.7 to 97 +/- 16 cm, p < 0.0001) and fasting insulin (137 +/- 94.8 to 121 +/- 83.4 pmol/L, p < 0.001) also decreased in participants who attended the final visit. Significant improvements were seen in all measures of PA, self-concept, and anxiety. CHW-SB, a government-funded program, is the first obesity-treatment program to be evaluated in Canada. While short-term evaluation revealed significant improvements in adiposity, PA, and psychological measures, the lack of full follow-up is a limitation in interpreting the clinical effectiveness of this program, as drop-out may be associated with lack of success in meeting program goals. These data also emphasize the need for ongoing evaluation to assess the long-term implications of this unique program and ultimately optimize utilization of governmental resources.
C1 [Panagiotopoulos, Constadina; Rurak, Erin; Chanoine, Jean-Pierre; Masse, Louise C.] Univ British Columbia, Dept Pediat, Vancouver, BC V6T 1Z4, Canada.
   [Panagiotopoulos, Constadina; Cristall, Arlene; Sneddon, Penny; Hinchliffe, Mary; Chanoine, Jean-Pierre] British Columbia Childrens Hosp, Vancouver, BC V6H 3V4, Canada.
   [Panagiotopoulos, Constadina; Brant, Rollin; Kuzeljevic, Boris; Chanoine, Jean-Pierre; Masse, Louise C.] Child & Family Res Inst, Vancouver, BC V5Z 4H4, Canada.
   [Ronsley, Rebecca] Univ Toronto, Toronto, ON M5S 1A1, Canada.
   [Al-Dubayee, Mohammed] King Saud Bin Abdulaziz Univ Hlth Sci, Dept Pediat, Riyadh, Saudi Arabia.
   [Brant, Rollin] Univ British Columbia, Dept Stat, Vancouver, BC V6T 1Z4, Canada.
   [Marks, Glynis] Nanaimo Reg Gen Hosp, Nanaimo, BC V9S 2B7, Canada.
   [Hinchliffe, Mary] Univ British Columbia, Dept Family Practice, Vancouver, BC V6T 1Z4, Canada.
   [Masse, Louise C.] Univ British Columbia, Sch Populat & Publ Hlth, Vancouver, BC V6T 1Z4, Canada.
C3 University of British Columbia; University of British Columbia; BC
   Children's Hospital; Child & Family Research Institute; University of
   Toronto; King Saud Bin Abdulaziz University for Health Sciences;
   University of British Columbia; University of British Columbia;
   University of British Columbia
RP Panagiotopoulos, C (corresponding author), Univ British Columbia, Dept Pediat, Vancouver, BC V6T 1Z4, Canada.
EM dpanagiotopoulos@cw.bc.ca; rebecca.ronsley@gmail.com;
   dubayeem@yahoo.com; rollin@stat.ubc.ca; bkuzel@cw.bc.ca;
   erinrurak@gmail.com; Arlene.Cristall@phsa.ca; glynis.marks@viha.ca;
   PSneddon@cw.bc.ca; mhinchliffe@cw.bc.ca; jchanoine@cw.bc.ca;
   lmasse@cfri.ubc.ca
RI Panagiotopoulos, Constadina/AAO-6827-2020; Chanoine,
   Jean-Pierre/K-5026-2019
OI Kuzeljevic, Boris/0000-0003-4712-9867; Sneddon,
   Penny/0000-0003-1293-1374; Chanoine, Jean-Pierre/0000-0002-5167-2064;
   Panagiotopoulos, Constadina/0000-0002-1379-7472; Masse,
   Louise/0000-0003-2483-8791; Brant, Rollin/0000-0002-8026-2451
FU Child & Family Research Institute (CFRI); Canadian Diabetes Association;
   Panagiotopoulos' CFRI
FX Panagiotopoulos receives salary support from the Child & Family Research
   Institute (CFRI) and Canadian Diabetes Association Clinician Scientist
   Awards. This work was also funded by Panagiotopoulos' CFRI establishment
   award.
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NR 59
TC 20
Z9 22
U1 0
U2 9
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-7827
EI 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD DEC
PY 2011
VL 8
IS 12
BP 4662
EP 4678
DI 10.3390/ijerph8124662
PG 17
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA 866TL
UT WOS:000298406600016
PM 22408595
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Compare, A
   Mommersteeg, PMC
   Faletra, F
   Grossi, E
   Pasotti, E
   Moccetti, T
   Auricchio, A
AF Compare, Angelo
   Mommersteeg, Paula M. C.
   Faletra, Francesco
   Grossi, Enzo
   Pasotti, Elena
   Moccetti, Tiziano
   Auricchio, Angelo
TI Personality traits, cardiac risk factors, and their association with
   presence and severity of coronary artery plaque in people with no
   history of cardiovascular disease
SO JOURNAL OF CARDIOVASCULAR MEDICINE
LA English
DT Article
DE anger; coronary artery disease; hostility; type D personality; coronary
   stenosis
ID HEART-DISEASE; METABOLIC SYNDROME; ANGER; HOSTILITY; ATHEROSCLEROSIS;
   CALCIFICATION; ANXIETY; PREDICT
AB Background
   Coronary artery disease (CAD) is a multifactorial complex disease. The aim of the present study is to verify whether the personality traits in CAD are associated with coronary artery plaque (CAP) presence and severity in people with no history of cardiovascular disease.
   Design
   A cross-sectional monocenter study.
   Methods
   Seventy five individuals with no history of CAD underwent 64-slice computed tomography coronary angiography (CTCA) and were screened for traditional cardiac risk factors and for hostility, anger, and type D personality traits.
   Results
   In total, 48 patients (64%) had evidence of CAP, with mild (31%), moderate (33%), and severe (35%) coronary stenosis. Male sex, hypertension, being overweight, and number of cardiovascular risk factors increased the likelihood of CAP presence. Findings showed a significant difference between CAP presence vs. CAP absence for anger (26 vs. 30%, chi(2) = 6.82) and type D personality (23 vs. 35%; chi(2) = 8.23, P = 0.03), but not hostility (P > 0.05). Anger personality, and the type D subscale social inhibition, but not negative affectivity, were associated with an increased prevalence and severity of CAP. Univariate analysis confirms anger (odds ratio, OR = 1.38, 95% confidence interval, CI = 1.12-2.31), social inhibition (OR = 2.01, 95% CI = 1.81-2.93), 'negative affectivity by social inhibition' (OR = 1.24, 95% CI = 1.12-2.14), and type D personality (OR = 1.9, 95% CI = 1.11-2.03) as predictors of CAP presence. Moreover, multivariate analysis suggests social inhibition as also a unique CAP predictor (OR = 2.14, 95% CI = 1.89-2.96) after adjustment for having cardiac risk factors as a covariate.
   Conclusion
   The present data confirm the core role of traditional risk factors and suggest the primacy of social inhibition and anger personality traits in association with CAP presence and severity.
C1 [Compare, Angelo] Univ Bergamo, Human Factors & Technol Hlth Care Ctr, Bergamo, Italy.
   [Mommersteeg, Paula M. C.] Tilburg Univ, Ctr Res Psychol Somat Dis, NL-5000 LE Tilburg, Netherlands.
   [Faletra, Francesco; Pasotti, Elena; Moccetti, Tiziano; Auricchio, Angelo] Cardioctr Lugano, Div Cardiol, Lugano, Switzerland.
   [Grossi, Enzo] Villa Santa Maria Inst, Tavernerio, Italy.
C3 University of Bergamo; Tilburg University
RP Compare, A (corresponding author), HTH Human Factors & Technol Hlth Care Ctr, Ple S Agostino 2, I-24129 Bergamo, Italy.
EM angelo.compare@unibg.it
RI Grossi, Enzo/AAF-7765-2020; Mommersteeg, Paula/AAB-7801-2019; Compare,
   Prof. Angelo/H-3519-2014
OI Compare, Prof. Angelo/0000-0002-3336-7920; GROSSI,
   ENZO/0000-0003-0346-2684
FU Sorin; Medtronic; Biotronik; EBR Systems; Abbott; Biologic delivery
   systems; Cordis Corporation; JJ company
FX A.A. has the following ongoing financial activities outside the
   submitted work: Sorin, Medtronic, Biotronik, EBR Systems, Abbott,
   Biologic delivery systems, Cordis Corporation and J&J company. For the
   remaining authors, none were declared.
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NR 39
TC 28
Z9 29
U1 0
U2 18
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1558-2027
EI 1558-2035
J9 J CARDIOVASC MED
JI J. Cardiovasc. Med.
PD MAY
PY 2014
VL 15
IS 5
BP 423
EP 430
DI 10.2459/JCM.0b013e328365cd8c
PG 8
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA AF8YO
UT WOS:000335002100012
PM 24572339
OA Green Published
DA 2025-06-11
ER

PT J
AU Bagnato, CB
   Bianco, A
   Bonfiglio, C
   Franco, I
   Verrelli, N
   Carella, N
   Shahini, E
   Zappimbulso, M
   Giannuzzi, V
   Pesole, PL
   Ancona, A
   Giannelli, G
AF Bagnato, Claudia Beatrice
   Bianco, Antonella
   Bonfiglio, Caterina
   Franco, Isabella
   Verrelli, Nicola
   Carella, Nicola
   Shahini, Endrit
   Zappimbulso, Marianna
   Giannuzzi, Vito
   Pesole, Pasqua Letizia
   Ancona, Anna
   Giannelli, Gianluigi
TI Healthy Lifestyle Changes Improve Cortisol Levels and Liver Steatosis in
   MASLD Patients: Results from a Randomized Clinical Trial
SO NUTRIENTS
LA English
DT Article
DE exercise; Mediterranean diet; hepatic steatosis; steatotic liver disease
   associated with metabolic dysfunction
ID PHYSICAL-ACTIVITY; EXERCISE; VALIDITY; RELIABILITY; QUESTIONNAIRE
AB Background: Steatotic liver disease associated with metabolic dysfunction (MASLD) affects up to about 30% of the general adult population and is closely related to obesity and the metabolic syndrome. Cortisol, a stress-related hormone contributing to hepatic fat accumulation and insulin resistance, also promotes progression of the disease. The study aims to investigate the impact of lifestyle modifications on cortisol levels and hepatic steatosis in patients with MASLD. Methods: In a 16-week three-arm randomized trial, 42 patients were randomly assigned to three groups who received dietary advice (CG), dietary advice combined with aerobic exercise (AE + DA), or dietary advice with high-intensity interval training (HIIT + DA). Before the start, after 2 months of intervention, and at the end of the project, medical evaluations, routine biochemical assessments, and psychological questionnaires were analyzed. At baseline and at the end of 4 months, hepatic steatosis was evaluated by Fibroscan (R). Results: In the study population, severe hepatic steatosis (74%) and obesity (98%) were prevalent at the beginning of the study. A statistically significant (p-value = 0.001) reduction in circulating cortisol levels was observed over time in the two groups doing exercise, especially in HIIT + DA (p-value = 0.006). Hepatic steatosis, assessed by Fibroscan (R), disappeared in 10 participants (CAP value < 248, p-value = 0.003). CAP values and waist circumference decreased in all groups, statistically significantly in the AE + DA group (p-value = 0.005; p-value = 0.04, respectively). Conclusions: The study emphasizes the benefits of combining diet and exercise in managing MASLD. HIIT + DA significantly decreased cortisol levels, while AE + DA was the most potent intervention for reducing hepatic steatosis.
C1 [Bagnato, Claudia Beatrice; Bianco, Antonella; Franco, Isabella; Verrelli, Nicola] Natl Inst Gastroenterol IRCCS Saverio Bellis, Lab Movement & Wellness, I-70013 Castellana Grotte, BA, Italy.
   [Bonfiglio, Caterina] Natl Inst Gastroenterol IRCCS Saverio Bellis, Data Sci, I-70013 Castellana Grotte, BA, Italy.
   [Carella, Nicola] Natl Inst Gastroenterol IRCCS Saverio Bellis, Clin Res Unit, I-70013 Castellana Grotte, BA, Italy.
   [Shahini, Endrit; Zappimbulso, Marianna; Giannuzzi, Vito] Natl Inst Gastroenterol IRCCS Saverio Bellis, Gastroenterol Unit, I-70013 Castellana Grotte, BA, Italy.
   [Pesole, Pasqua Letizia; Ancona, Anna] Natl Inst Gastroenterol IRCCS Saverio Bellis, Core Facil Biobank, I-70013 Castellana Grotte, BA, Italy.
   [Giannelli, Gianluigi] Natl Inst Gastroenterol IRCCS Saverio Bellis, Sci Direct, I-70013 Castellana Grotte, BA, Italy.
RP Bianco, A (corresponding author), Natl Inst Gastroenterol IRCCS Saverio Bellis, Lab Movement & Wellness, I-70013 Castellana Grotte, BA, Italy.
EM claudia.bagnato@irccsdebellis.it; antonella.bianco@irccsdebellis.it;
   catia.bonfiglio@irccsdebellis.it; isabella.franco@irccsdebellis.it;
   nicola.verrelli@irccsdebellis.it; nicola.carella@irccsdebellis.it;
   endrit.shahini@irccsdebellis.it; marianna.zappimbulso@irccsdebellis.it;
   vito.giannuzzi@irccsdebellis.it; letizia.pesole@irccsdebellis.it;
   anna.ancona@irccsdebellis.it; gianluigi.giannelli@irccsdebellis.it
RI giannelli, gianluigi/A-8169-2012; Shahini, Endrit/AAX-7646-2021;
   Giannelli, Gianluigi/K-5123-2016
OI Bonfiglio, Caterina/0000-0002-8650-348X; Ancona,
   Anna/0009-0009-7662-1763; Shahini, Endrit/0000-0002-4909-0436; pesole,
   pasqua letizia/0000-0003-4675-2075; Giannelli,
   Gianluigi/0000-0002-5140-8060
FU the Italian Ministry of Health [RC 2024]; Italian Ministry of Health
FX This research was funded by the Italian Ministry of Health RC 2024.
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NR 61
TC 1
Z9 1
U1 0
U2 0
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD DEC
PY 2024
VL 16
IS 23
AR 4225
DI 10.3390/nu16234225
PG 21
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA P3W7N
UT WOS:001377259200001
PM 39683618
OA gold
DA 2025-06-11
ER

PT J
AU Mandelblatt, JS
   Antoni, MH
   Bethea, TN
   Cole, S
   Hudson, B
   Penedo, FJ
   Ramirez, AG
   Rebeck, GW
   Sarkar, S
   Schwartz, AG
   Sloan, EK
   Zheng, YL
   Carroll, JE
   Sedrak, MS
AF Mandelblatt, Jeanne S.
   Antoni, Michael H.
   Bethea, Traci N.
   Cole, Steve
   Hudson, Barry, I
   Penedo, Frank J.
   Ramirez, Amelie G.
   Rebeck, G. William
   Sarkar, Swarnavo
   Schwartz, Ann G.
   Sloan, Erica K.
   Zheng, Yun-Ling
   Carroll, Judith E.
   Sedrak, Mina S.
TI Gerotherapeutics: aging mechanism-based pharmaceutical and behavioral
   interventions to reduce cancer racial and ethnic disparities
SO JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
LA English
DT Review
ID HEALTH-CARE DISPARITIES; RANDOMIZED CONTROLLED-TRIAL; STRESS-MANAGEMENT;
   AFRICAN-AMERICAN; SENESCENT CELLS; UNITED-STATES; METABOLIC SYNDROME;
   STRUCTURAL RACISM; TUMOR SUPPRESSION; OLDER PATIENTS
AB The central premise of this article is that a portion of the established relationships between social determinants of health and racial and ethnic disparities in cancer morbidity and mortality is mediated through differences in rates of biological aging processes. We further posit that using knowledge about aging could enable discovery and testing of new mechanism-based pharmaceutical and behavioral interventions ("gerotherapeutics") to differentially improve the health of cancer survivors from minority populations and reduce cancer disparities. These hypotheses are based on evidence that lifelong differences in adverse social determinants of health contribute to disparities in rates of biological aging ("social determinants of aging"), with individuals from minoritized groups experiencing accelerated aging (ie, a steeper slope or trajectory of biological aging over time relative to chronological age) more often than individuals from nonminoritized groups. Acceleration of biological aging can increase the risk, age of onset, aggressiveness, and stage of many adult cancers. There are also documented negative feedback loops whereby the cellular damage caused by cancer and its therapies act as drivers of additional biological aging. Together, these dynamic intersectional forces can contribute to differences in cancer outcomes between survivors from minoritized vs nonminoritized populations. We highlight key targetable biological aging mechanisms with potential applications to reducing cancer disparities and discuss methodological considerations for preclinical and clinical testing of the impact of gerotherapeutics on cancer outcomes in minoritized populations. Ultimately, the promise of reducing cancer disparities will require broad societal policy changes that address the structural causes of accelerated biological aging and ensure equitable access to all new cancer control paradigms.
C1 [Mandelblatt, Jeanne S.] Georgetown Univ, Georgetown Lombardi Inst Canc & Aging Res, Lombardi Comprehens Canc Ctr, Washington, DC USA.
   [Mandelblatt, Jeanne S.; Bethea, Traci N.; Hudson, Barry, I; Sarkar, Swarnavo; Zheng, Yun-Ling] Georgetown Univ, Med Ctr, Dept Oncol, Washington, DC USA.
   [Antoni, Michael H.; Penedo, Frank J.] Univ Miami, Sylvester Comprehens Canc Ctr, Dept Psychol, Hlth Div, Miami, FL USA.
   [Antoni, Michael H.; Penedo, Frank J.] Univ Miami, Sylvester Comprehens Canc Ctr, Miami, FL USA.
   [Cole, Steve; Carroll, Judith E.] Univ Calif Los Angeles, Semel Inst Neurosci & Human Behav, Dept Psychiat & Biobehav Sci, Los Angeles, CA USA.
   [Cole, Steve; Carroll, Judith E.] Univ Calif Los Angeles, Cousins Ctr Psychoneuroimmunol, Northridge, CA USA.
   [Ramirez, Amelie G.] Univ Texas Hlth Sci Ctr San Antonio, Dept Populat Hlth Sci, San Antonio, TX USA.
   [Rebeck, G. William] Georgetown Univ, Med Ctr, Dept Neurosci, Washington, DC USA.
   [Schwartz, Ann G.] Wayne State Univ, Karmanos Canc Inst, Detroit, MI USA.
   [Sloan, Erica K.] Monash Univ, Monash Inst Pharmaceut Sci, Drug Discovery Biol Theme, Melbourne, Vic, Australia.
   [Carroll, Judith E.; Sedrak, Mina S.] Univ Calif Los Angeles, Canc Prevent & Control Program, Jonsson Comprehens Canc Ctr, Los Angeles, CA USA.
C3 Georgetown University; Georgetown University; University of Miami;
   University of Miami; University of California System; University of
   California Los Angeles; University of California System; University of
   California Los Angeles; University of Texas System; University of Texas
   Health Science Center at San Antonio; Georgetown University; Barbara Ann
   Karmanos Cancer Institute; Wayne State University; Monash University;
   University of California System; University of California Los Angeles;
   UCLA Jonsson Comprehensive Cancer Center
RP Mandelblatt, JS (corresponding author), Georgetown Univ, Canc Prevent & Control Program, 2115 Wisconsin Ave,Third Floor, Washington, DC 20007 USA.; Mandelblatt, JS (corresponding author), Georgetown Univ, Inst Canc & Aging Res, Lombardi Comprehens Canc Ctr, 2115 Wisconsin Ave,Third Floor, Washington, DC 20007 USA.
EM mandelbj@georgetown.edu
RI Carroll, Judith/W-5014-2019; Cole, Steve/KYO-7764-2024; Rebeck,
   George/J-2192-2012
OI Antoni, Michael/0000-0002-3971-0873; Cole, Steve/0000-0002-7168-8039;
   Rebeck, G. William/0000-0001-6276-248X; Bethea,
   Traci/0000-0003-3205-2078; Ramirez, Amelie/0000-0002-5310-1337
FU National Cancer Institute at the National Institutes of Health
   [R35CA283926, R01CA129769, R35CA197289, U01CA253911, K01CA212056,
   R01CA276587, U01CA199240, UG3CA260317, R01CA280088, R21CA277660];
   National Institute on Aging at the National Institutes of Health
   [R56AG068086, R01AG082348, R21AG075008, R33AG075008, U01ES031786,
   K76AG074918, R01AG067258]; National Breast Cancer Foundation
   [IIRS-20-025]; National Health and Medical Research Council [2020851];
   Cancer Council Victoria
FX This work was supported by the National Cancer Institute at the National
   Institutes of Health grant No. R35CA283926 (J.S.M.). This research was
   also supported in part by National Cancer Institute at the National
   Institutes of Health grant No. R01CA129769 and R35CA197289 (J.S.M.),
   U01CA253911 (J.S.M. and S.S.), K01CA212056 (T.N.B.), R01CA276587 (B.H.),
   U01CA199240 (A.G.S.), UG3CA260317 (F.J.P. and A.G.R.), R01CA280088
   (M.S.S.), R21CA277660 (M.S.S.), and U01CA253911 (J.M. and S.S.) and the
   National Institute on Aging at the National Institutes of Health grant
   No. R56AG068086, R01AG082348, R21AG075008, and R33AG075008 (J.E.C. and
   J.S.M.), U01ES031786 (Y.L.Z.), K76AG074918 (M.S.S.), and R01AG067258 (G.
   W.R.). E.K.S. was supported in part by grant funding from the National
   Breast Cancer Foundation (IIRS-20-025), the National Health and Medical
   Research Council (2020851), and Cancer Council Victoria Grants-in-Aid.
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NR 274
TC 1
Z9 1
U1 1
U2 2
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0027-8874
EI 1460-2105
J9 JNCI-J NATL CANCER I
JI JNCI-J. Natl. Cancer Inst.
PD OCT 17
PY 2024
VL 117
IS 3
DI 10.1093/jnci/djae211
EA OCT 2024
PG 18
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA Z3P5Z
UT WOS:001333657000001
PM 39196709
DA 2025-06-11
ER

PT J
AU Mazaheri-Tehrani, S
   Abhari, AP
   Ostadsharif, N
   Shekarian, A
   Vali, M
   Saffari, E
   Anaraki, KT
   Haghighatpanah, MA
   Fakhrolmobasheri, M
   Kieliszek, M
AF Mazaheri-Tehrani, Sadegh
   Abhari, Amir Parsa
   Ostadsharif, Negar
   Shekarian, Arman
   Vali, Mahshad
   Saffari, Elahe
   Anaraki, Kasra Talebi
   Haghighatpanah, Mohammad Ali
   Fakhrolmobasheri, Mohammad
   Kieliszek, Marek
TI Serum Selenium Levels and Lipid Profile: A Systematic Review and
   Meta-analysis of Observational Studies
SO BIOLOGICAL TRACE ELEMENT RESEARCH
LA English
DT Article
DE Lipid profile; Triglycerides; Selenium; Low-density lipoprotein;
   High-density lipoprotein; Total cholesterol
ID GLUTATHIONE-PEROXIDASE CONCENTRATIONS; CARDIOVASCULAR RISK-FACTORS;
   POLYCYSTIC-OVARY-SYNDROME; TYPE-1 DIABETES-MELLITUS; TRACE-ELEMENTS;
   METABOLIC SYNDROME; OXIDATIVE STRESS; PLASMA SELENIUM; HEART-DISEASE;
   ZINC
AB Selenium is a trace element with pivotal roles in metabolic processes. Studies suggested that selenium deficiency could lead to impaired lipid profiles. However, inconsistent results have been reported regarding the association between serum selenium concentrations and lipid profile (triglycerides, LDL, HDL, VLDL, and total cholesterol). Thus, we aimed to review the correlation between them. A systematic literature search was conducted in PubMed, Embase, Web of Science, Scopus, and Google Scholar until 31 December 2023. The relevant correlation coefficients were used as desired effect sizes to assess the correlation between selenium level and lipid profile. Among 8291 records found in the primary search, 47 and 34 articles were included in the systematic review and meta-analysis, respectively. All included studies were observational investigations and had acceptable quality. Our results failed to reach strong evidence supporting the correlation between serum selenium level and lipid profiles, except for HDL, which showed a weak correlation among both adults (r = 0.1 [0.03:0.17]; I2 = 71%) and pediatrics (r = 0.08 [0.03:0.14]; I2 = 38%). Subgroup analyses based on gender did not reveal a significant or strong correlation with selenium levels (except for total cholesterol in males (r = 0.12 [0.01:0.22]; I2 = 52%)). The results did not change after the sensitivity analysis. Although some previous studies have suggested that selenium deficiency could lead to impaired lipid profile, the findings of this study indicate no strong correlation between serum selenium levels and lipid profile.
C1 [Mazaheri-Tehrani, Sadegh; Anaraki, Kasra Talebi] Isfahan Univ Med Sci, Res Inst Primordial Prevent Noncommunicable Dis, Child Growth & Dev Res Ctr, Biostat, Esfahan, Iran.
   [Mazaheri-Tehrani, Sadegh] Isfahan Univ Med Sci, Isfahan Cardiovasc Res Inst, Esfahan, Iran.
   [Mazaheri-Tehrani, Sadegh; Ostadsharif, Negar] Isfahan Univ Med Sci, Student Res Comm, Esfahan, Iran.
   [Abhari, Amir Parsa; Fakhrolmobasheri, Mohammad] Isfahan Univ Med Sci, Isfahan Cardiovasc Res Inst, Heart Failure Res Ctr, Esfahan, Iran.
   [Shekarian, Arman; Saffari, Elahe] Isfahan Univ Med Sci, Isfahan Endocrine & Metab Res Ctr, Esfahan, Iran.
   [Vali, Mahshad] Isfahan Univ Med Sci, Sch Med, Esfahan, Iran.
   [Haghighatpanah, Mohammad Ali] Isfahan Univ Med Sci, Chamran Heart Ctr, Dept Cardiovasc Surg, Esfahan, Iran.
   [Kieliszek, Marek] Warsaw Univ Life Sci SGGW, Inst Food Sci, Dept Food Biotechnol & Microbiol, Nowoursynowska 159C, PL-02776 Warsaw, Poland.
C3 Isfahan University of Medical Sciences; Isfahan University of Medical
   Sciences; Isfahan University of Medical Sciences; Isfahan University of
   Medical Sciences; Isfahan University of Medical Sciences; Isfahan
   University of Medical Sciences; Isfahan University of Medical Sciences;
   Warsaw University of Life Sciences
RP Mazaheri-Tehrani, S (corresponding author), Isfahan Univ Med Sci, Res Inst Primordial Prevent Noncommunicable Dis, Child Growth & Dev Res Ctr, Biostat, Esfahan, Iran.; Mazaheri-Tehrani, S (corresponding author), Isfahan Univ Med Sci, Isfahan Cardiovasc Res Inst, Esfahan, Iran.; Mazaheri-Tehrani, S (corresponding author), Isfahan Univ Med Sci, Student Res Comm, Esfahan, Iran.; Abhari, AP (corresponding author), Isfahan Univ Med Sci, Isfahan Cardiovasc Res Inst, Heart Failure Res Ctr, Esfahan, Iran.; Kieliszek, M (corresponding author), Warsaw Univ Life Sci SGGW, Inst Food Sci, Dept Food Biotechnol & Microbiol, Nowoursynowska 159C, PL-02776 Warsaw, Poland.
EM s.mazaheri@edc.mui.ac.ir; amirparsaabhari@gmail.com;
   marek-kieliszek@wp.pl
RI Tehrani, Sadegh/ABE-4673-2021; Shekarian, Arman/MTD-1892-2025;
   fakhrolmobasheri, mohammad/AAU-7014-2021; Kieliszek, Marek/V-4421-2018
OI Kieliszek, Marek/0000-0002-5836-4865; Shekarian,
   Arman/0009-0001-3616-4766; Mazaheri-Tehrani, Sadegh/0000-0002-7199-5696
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NR 93
TC 1
Z9 1
U1 3
U2 3
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0163-4984
EI 1559-0720
J9 BIOL TRACE ELEM RES
JI Biol. Trace Elem. Res.
PD MAY
PY 2025
VL 203
IS 5
BP 2517
EP 2538
DI 10.1007/s12011-024-04365-4
EA SEP 2024
PG 22
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 3GG8R
UT WOS:001309271600001
PM 39256333
OA hybrid
DA 2025-06-11
ER

PT J
AU Furusho, T
   Uchida, S
   Sohara, E
AF Furusho, Taisuke
   Uchida, Shinichi
   Sohara, Eisei
TI The WNK signaling pathway and salt-sensitive hypertension
SO HYPERTENSION RESEARCH
LA English
DT Review
DE Hypertension; NaCl cotransporter; Salt sensitivity; WNK signaling
ID PSEUDOHYPOALDOSTERONISM TYPE-II; SODIUM-CHLORIDE COTRANSPORTER;
   DISEASE-CAUSING MUTATIONS; NA-CL COTRANSPORTER; KELCH-LIKE 3; FAMILIAL
   HYPERKALEMIC HYPERTENSION; ANGIOTENSIN-II; PROTEIN-KINASE;
   BLOOD-PRESSURE; URINARY SODIUM
AB The distal nephron of the kidney has a central role in sodium and fluid homeostasis, and disruption of this homeostasis due to mutations of with-no-lysine kinase 1 (WNK1), WNK4, Kelch-like 3 (KLHL3), or Cullin 3 (CUL3) causes pseudohypoaldosteronism type II (PHAII), an inherited hypertensive disease. WNK1 and WNK4 activate the NaCl cotransporter (NCC) at the distal convoluted tubule through oxidative stress-responsive gene 1 (OSR1)/Ste20-related proline-alanine-rich kinase (SPAK), constituting the WNK-OSR1/SPAK-NCC phosphorylation cascade. The level of WNK protein is regulated through degradation by the CUL3-KLHL3 E3 ligase complex. In the normal state, the activity of WNK signaling in the kidney is physiologically regulated by sodium intake to maintain sodium homeostasis in the body. In patients with PHAII, however, because of the defective degradation of WNK kinases, NCC is constitutively active and not properly suppressed by a high salt diet, leading to abnormally increased salt reabsorption and salt-sensitive hypertension. Importantly, recent studies have demonstrated that potassium intake, insulin, and TNF alpha are also physiological regulators of WNK signaling, suggesting that they contribute to the salt-sensitive hypertension associated with a low potassium diet, metabolic syndrome, and chronic kidney disease, respectively. Moreover, emerging evidence suggests that WNK signaling also has some unique roles in metabolic, cardiovascular, and immunological organs. Here, we review the recent literature and discuss the molecular mechanisms of the WNK signaling pathway and its potential as a therapeutic target.
C1 [Furusho, Taisuke; Uchida, Shinichi; Sohara, Eisei] Tokyo Med & Dent Univ, Grad Sch Med & Dent Sci, Dept Nephrol, Tokyo, Japan.
C3 Institute of Science Tokyo; Tokyo Medical & Dental University (TMDU)
RP Sohara, E (corresponding author), Tokyo Med & Dent Univ, Grad Sch Med & Dent Sci, Dept Nephrol, Tokyo, Japan.
EM esohara.kid@tmd.ac.jp
RI Furusho, Taisuke/KXR-7433-2024
OI Furusho, Taisuke/0009-0001-5339-140X
FU Japan Society for the Promotion of Science (JSPS) [25221306-00,
   19H01049, 18K19534, 16H05314, 19H03672]; Ministry of Health, Labor, and
   Welfare, AMED [JP18ek0109304]; Yukiko Ishibashi Foundation; Salt Science
   Research Foundation; Grants-in-Aid for Scientific Research [19H01049,
   19H03672, 18K19534] Funding Source: KAKEN
FX This work was supported in part by Grants-in-Aid for Scientific Research
   (KAKENHI) from the Japan Society for the Promotion of Science (JSPS)
   [Grant Numbers: 25221306-00, 19H01049, 18K19534, 16H05314, and
   19H03672], a Health Labor Science Research Grant from the Ministry of
   Health, Labor, and Welfare, AMED under Grant Number JP18ek0109304, and
   grants from the Yukiko Ishibashi Foundation and the Salt Science
   Research Foundation (1925).
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NR 112
TC 35
Z9 35
U1 1
U2 20
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0916-9636
EI 1348-4214
J9 HYPERTENS RES
JI Hypertens. Res.
PD AUG
PY 2020
VL 43
IS 8
BP 733
EP 743
DI 10.1038/s41440-020-0437-x
EA APR 2020
PG 11
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA MK3HG
UT WOS:000526242900001
PM 32286498
DA 2025-06-11
ER

PT J
AU Hoekstra, M
   van der Sluis, RJ
   Hildebrand, RB
   Lammers, B
   Zhao, Y
   Praticò, D
   van Berkel, TJC
   Rensen, PCN
   Kooijman, S
   Jauhiainen, M
   van Eck, M
AF Hoekstra, Menno
   van der Sluis, Ronald J.
   Hildebrand, Reeni B.
   Lammers, Bart
   Zhao, Ying
   Pratico, Domenico
   van Berkel, Theo J. C.
   Rensen, Patrick C. N.
   Kooijman, Sander
   Jauhiainen, Matti
   van Eck, Miranda
TI Disruption of Phospholipid Transfer Protein-Mediated High-Density
   Lipoprotein Maturation Reduces Scavenger Receptor BI Deficiency-Driven
   Atherosclerosis Susceptibility Despite Unexpected Metabolic
   Complications
SO ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
LA English
DT Article
DE atherosclerosis; diet; high fat; hypertriglyceridemia; mice; obesity
ID APOLIPOPROTEIN-E; TARGETED MUTATION; KNOCKOUT MICE; CHOLESTEROL; HDL;
   EXPRESSION; BINDING; LIVER; METAANALYSIS; DELETION
AB Objective:
   We tested the hypothesis that enlarged, dysfunctional HDL (high-density lipoprotein) particles contribute to the augmented atherosclerosis susceptibility associated with SR-BI (scavenger receptor BI) deficiency in mice.
   Approach and Results:
   We eliminated the ability of HDL particles to fully mature by targeting PLTP (phospholipid transfer protein) functionality. Particle size of the HDL population was almost fully normalized in male and female SR-BIxPLTP double knockout mice. In contrast, the plasma unesterified cholesterol to cholesteryl ester ratio remained elevated. The PLTP deficiency-induced reduction in HDL size in SR-BI knockout mice resulted in a normalized aortic tissue oxidative stress status on Western-type diet. Atherosclerosis susceptibility was-however-only partially reversed in double knockout mice, which can likely be attributed to the fact that they developed a metabolic syndrome-like phenotype characterized by obesity, hypertriglyceridemia, and a reduced glucose tolerance. Mechanistic studies in chow diet-fed mice revealed that the diminished glucose tolerance was probably secondary to the exaggerated postprandial triglyceride response. The absence of PLTP did not affect LPL (lipoprotein lipase)-mediated triglyceride lipolysis but rather modified the ability of VLDL (very low-density lipoprotein)/chylomicron remnants to be cleared from the circulation by the liver through receptors other than SR-BI. As a result, livers of double knockout mice only cleared 26% of the fractional dose of [C-14]cholesteryl oleate after intravenous VLDL-like particle injection.
   Conclusions:
   We have shown that disruption of PLTP-mediated HDL maturation reduces SR-BI deficiency-driven atherosclerosis susceptibility in mice despite the induction of proatherogenic metabolic complications in the double knockout mice.
C1 [Hoekstra, Menno; van der Sluis, Ronald J.; Hildebrand, Reeni B.; Lammers, Bart; Zhao, Ying; van Berkel, Theo J. C.; van Eck, Miranda] Leiden Acad Ctr Drug Res, Div BioTherapeut, Leiden, Netherlands.
   [Pratico, Domenico] Alzheimers Ctr Temple, Dept Pharmacol, Philadelphia, PA USA.
   [Rensen, Patrick C. N.; Kooijman, Sander] Leiden Univ, Med Ctr, Dept Med, Div Endocrinol, Leiden, Netherlands.
   [Rensen, Patrick C. N.; Kooijman, Sander] Leiden Univ, Med Ctr, Einthoven Lab Expt Vasc & Regenerat Med, Leiden, Netherlands.
   [Jauhiainen, Matti] Minerva Fdn, Biomedicum, Helsinki, Finland.
C3 Leiden University; Leiden University Medical Center (LUMC); Leiden
   University - Excl LUMC; Leiden University; Leiden University Medical
   Center (LUMC); Leiden University - Excl LUMC; University of Helsinki
RP Hoekstra, M (corresponding author), Leiden Acad Ctr Drug Res, Div BioTherapeut, Gorlaeus Labs, Einsteinweg 55, NL-2333 CC Leiden, Netherlands.
EM hoekstra@lacdr.leidenuniv.nl
RI Van Berkel, Theo/ABD-7677-2021; Pratico, Domenico/ABA-9590-2020; , Menno
   Hoekstra/JZX-5113-2024; van Eck, Miranda/LTC-5020-2024; Zhao,
   Ying/AAS-7970-2021; Rensen, Patrick/D-7176-2018; Kooijman,
   Sander/S-3857-2016
OI Rensen, Patrick/0000-0002-8455-4988; Kooijman,
   Sander/0000-0002-0014-5571; van Eck, Miranda/0000-0003-3936-3194
FU Netherlands Organization for Scientific Research (VICI grant)
   [91813603]; Academy of Finland [257545]; Finnish Foundation for
   Cardiovascular Research; Dutch Heart Foundation [2009T038, 2007T056]
FX This study was supported by the Netherlands Organization for Scientific
   Research (VICI grant 91813603 to M. van Eck), the Academy of Finland
   (grant #257545 to M. Jauhiainen) and the Finnish Foundation for
   Cardiovascular Research (to M. Jauhiainen). P.C.N. Rensen and M. van Eck
   are Established Investigators of the Dutch Heart Foundation (grants
   2009T038 and 2007T056, respectively).
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NR 38
TC 7
Z9 8
U1 0
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1079-5642
EI 1524-4636
J9 ARTERIOSCL THROM VAS
JI Arterioscler. Thromb. Vasc. Biol.
PD MAR
PY 2020
VL 40
IS 3
BP 611
EP 623
DI 10.1161/ATVBAHA.119.313862
PG 13
WC Hematology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Hematology; Cardiovascular System & Cardiology
GA LG3QE
UT WOS:000528018700017
PM 31941380
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Hammoutene, A
   Rautou, PE
AF Hammoutene, Adel
   Rautou, Pierre-Emmanuel
TI Role of liver sinusoidal endothelial cells in non-alcoholic fatty liver
   disease
SO JOURNAL OF HEPATOLOGY
LA English
DT Review
DE Endothelium; Steatosis; Capillarization; Endothelial dysfunction;
   Angiogenesis
ID ACTIVATED PROTEIN-KINASE; LOW-DENSITY-LIPOPROTEIN; NEGATIVE FEEDBACK
   LOOP; ACETYL-COA CARBOXYLASE; GROWTH-FACTOR; HEPATIC MICROCIRCULATION;
   INSULIN-RESISTANCE; NITRIC-OXIDE; RAT-LIVER; V-PYRRO/NO
AB Non-alcoholic fatty liver disease (NAFLD) and its complications are an expanding health problem associated with the metabolic syndrome. Liver sinusoidal endothelial cells (LSECs) are highly specialized endothelial cells localized at the interface between the blood derived from the gut and the adipose tissue on the one side, and other liver cells on the other side. In physiological conditions, LSECs are gatekeepers of liver homeostasis. LSECs display anti-inflammatory and anti-fibrogenic properties by preventing Kupffer cell and hepatic stellate cell activation and regulating intrahepatic vascular resistance and portal pressure. This review focusses on changes occurring in LSECs in NAFLD and on their consequences on NAFLD progression and complications. Capillarization, namely the loss of LSEC fenestrae, and LSEC dysfunction, namely the loss of the ability of LSECs to generate vasodilator agents in response to increased shear stress both occur early in NAFLD. These LSEC changes favour steatosis development and set the stage for NAFLD progression. At the stage of non-alcoholic steatohepatitis, altered LSECs release inflammatory mediators and contribute to the recruitment of inflammatory cells, thus promoting liver injury and inflammation. Altered LSECs also fail to maintain hepatic stellate cell quiescence and release fibrogenic mediators, including Hedgehog signalling molecules, promoting liver fibrosis. Liver angiogenesis is increased in NAFLD and contributes to liver inflammation and fibrosis, but also to hepatocellular carcinoma development. Thus, improving LSEC health appears to be a promising approach to prevent NAFLD progression and complications. (C) 2019 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
C1 [Hammoutene, Adel; Rautou, Pierre-Emmanuel] Paris Cardiovasc Res Ctr, PARCC, INSERM, UMR 970, Paris, France.
   [Hammoutene, Adel] Univ Paris 05, Paris, France.
   [Rautou, Pierre-Emmanuel] INSERM, UMR1149, Ctr Rech Sur Inflammat, Paris, France.
   [Rautou, Pierre-Emmanuel] Univ Paris Diderot, Paris, France.
   [Rautou, Pierre-Emmanuel] Hop Beaujon, AP HP, Pole Malad Appareil Digestif, DHU Unity,Ctr Reference Malad Vasc Foie,Serv Hepa, Clichy, France.
C3 Universite Paris Cite; Institut National de la Sante et de la Recherche
   Medicale (Inserm); Universite Paris Cite; Institut National de la Sante
   et de la Recherche Medicale (Inserm); Universite Paris Cite; Universite
   Paris Cite; Universite Paris Cite; Assistance Publique Hopitaux Paris
   (APHP); Hopital Universitaire Beaujon - APHP
RP Rautou, PE (corresponding author), Hop Beaujon, Serv Hepatol, 100 Blvd Gen Leclerc, F-92100 Clichy, France.
EM pierre-emma-nuel.rautou@inserm.fr
RI HAMMOUTENE, Adel/HKE-2671-2023; Rautou, Pierre-Emmanuel/ISA-6844-2023
OI HAMMOUTENE, Adel/0000-0001-6928-7431; Rautou,
   Pierre-Emmanuel/0000-0001-9567-1859
FU "Institut National de la Sante et de la Recherche Medicale" (ATIP
   AVENIR), Paris Descartes University; Agence Nationale pour la Recherche
   [ANR-14-CE12-0011, ANR-14-CE35-0022, ANR-18-CE14-000601]; "Association
   Francaise pour l'Etude du foie" (AFEF 2014); Ministere de l'Enseignement
   Superieur et de la Recherche; Agence Nationale de la Recherche (ANR)
   [ANR-14-CE12-0011, ANR-14-CE35-0022] Funding Source: Agence Nationale de
   la Recherche (ANR)
FX This work was supported by the "Institut National de la Sante et de la
   Recherche Medicale" (ATIP AVENIR), Paris Descartes University, the
   "Agence Nationale pour la Recherche" (ANR-14-CE12-0011,
   ANR-14-CE35-0022, ANR-18-CE14-000601) and by the "Association Francaise
   pour l'Etude du foie" (AFEF 2014). A.H. was supported by the "Ministere
   de l'Enseignement Superieur et de la Recherche".
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NR 147
TC 246
Z9 257
U1 5
U2 95
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0168-8278
EI 1600-0641
J9 J HEPATOL
JI J. Hepatol.
PD JUN
PY 2019
VL 70
IS 6
BP 1278
EP 1291
DI 10.1016/j.jhep.2019.02.012
PG 14
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA HY2XV
UT WOS:000467987600027
PM 30797053
OA Green Published, Bronze
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Li, B
   Wu, J
   Jiang, PJ
   Li, MG
   Liu, QY
   Cao, Y
   Wang, S
AF Li, Bo
   Wu, Jun
   Jiang, Pengjun
   Li, Maogui
   Liu, Qingyuan
   Cao, Yong
   Wang, Shuo
TI Serum fatty acid binding protein 4 is positively associated with early
   stroke recurrence in nondiabetic ischemic stroke
SO AGING-US
LA English
DT Article
DE adipocyte fatty acid-binding protein; stroke recurrence; ischemic stroke
ID 25-HYDROXYVITAMIN D PREDICTS; FABP4; BIOMARKER; MACROPHAGES; ADIPOCYTES;
   RESPONSES; COPEPTIN; OBESITY; STRESS; LEVEL
AB Adipocyte fatty acid-binding protein (FABP4) played critical roles in metabolic syndrome, inflammatory responses and cardiovascular diseases. It aimed to investigate the associations of serum FABP4 levels with early stroke recurrence. This study included the 206 acute ischemic stroke patients hospitalized in our institution. Stroke recurrence events were assessed at the 3-month follow-up. The median of FABP level was 22.6 (IQR, 17.9-31.6) ng/mL in patients with stroke recurrence (N=36), which was higher than in patients without stroke recurrence [16.9 (IQR, 11.8-21.4) ng/mL] (P<0.001). As a continuous variable, the unadjusted and adjusted risk of stroke recurrence would be increased by 12% (OR=1.12 [95% CI 1.06-1.17], P<0.001) and 8% (1.08 [1.02-1.14], P=0.006) for every 1 ng/ml increment of FABP4. The Area under the curve (AUC) of serum FABP4 and NIH Stroke Scale (NIHSS) score for predicting stroke recurrence was 0.73 (95% CI: 0.64-0.82) and 0.72 (95% CI: 0.64-0.81), presenting no discriminating capacity (P=0.45). In the combining model, the AUC of NIHSS score was further improved to 0.77 by FABP4 (0.77; 95% CI: 0.69-0.85), which was significant (P=0.01). The risk of stroke recurrence can be predicted by elevated FABP4 levels in serum of nondiabetic patients with first-ever ischemic stroke.
C1 [Li, Bo; Wu, Jun; Jiang, Pengjun; Li, Maogui; Liu, Qingyuan; Cao, Yong; Wang, Shuo] Capital Med Univ, Beijing Tiantan Hosp, Dept Neurosurg, Beijing, Peoples R China.
   [Li, Bo; Wu, Jun; Jiang, Pengjun; Li, Maogui; Liu, Qingyuan; Cao, Yong; Wang, Shuo] China Natl Clin Res Ctr Neurol Dis, Beijing, Peoples R China.
   [Li, Bo; Wu, Jun; Jiang, Pengjun; Li, Maogui; Liu, Qingyuan; Cao, Yong; Wang, Shuo] Beijing Inst Brain Disorders, Ctr Stroke, Beijing, Peoples R China.
   [Li, Bo; Wu, Jun; Jiang, Pengjun; Li, Maogui; Liu, Qingyuan; Cao, Yong; Wang, Shuo] Beijing Key Lab Translat Med Cerebrovasc Dis, Beijing, Peoples R China.
C3 Capital Medical University; Capital Medical University
RP Wang, S (corresponding author), Capital Med Univ, Beijing Tiantan Hosp, Dept Neurosurg, Beijing, Peoples R China.; Wang, S (corresponding author), China Natl Clin Res Ctr Neurol Dis, Beijing, Peoples R China.; Wang, S (corresponding author), Beijing Inst Brain Disorders, Ctr Stroke, Beijing, Peoples R China.; Wang, S (corresponding author), Beijing Key Lab Translat Med Cerebrovasc Dis, Beijing, Peoples R China.
EM captian9858@126.com
RI Li, M/AAG-4101-2019; Liu, Qingyuan/AAY-3335-2021
FU National Natural Science Foundation of China [81671129]; National Key
   Research and Development Program of China [2016YFC1301800]
FX This study was supported by the projects of National Natural Science
   Foundation of China (Grant No. 81671129) and the National Key Research
   and Development Program of China (Grant No. 2016YFC1301800).
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NR 57
TC 4
Z9 4
U1 1
U2 9
PU IMPACT JOURNALS LLC
PI ORCHARD PARK
PA 6666 E QUAKER ST, STE 1, ORCHARD PARK, NY 14127 USA
SN 1945-4589
J9 AGING-US
JI Aging-US
PD APR 15
PY 2019
VL 11
IS 7
BP 1977
EP 1989
DI 10.18632/aging.101886
PG 13
WC Cell Biology; Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Geriatrics & Gerontology
GA HV4MF
UT WOS:000465959700008
PM 30969942
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Montalbano, G
   Mania, M
   Abbate, F
   Navarra, M
   Guerrera, MC
   Laura, R
   Vega, JA
   Levanti, M
   Germanà, A
AF Montalbano, G.
   Mania, M.
   Abbate, F.
   Navarra, M.
   Guerrera, M. C.
   Laura, R.
   Vega, J. A.
   Levanti, M.
   Germana, A.
TI Melatonin treatment suppresses appetite genes and improves adipose
   tissue plasticity in diet-induced obese zebrafish
SO ENDOCRINE
LA English
DT Article
DE Melatonin; Diet-induced obesity; Zebrafish; Adipose tissue
ID GOLDFISH CARASSIUS-AURATUS; REDUCES BODY-WEIGHT; METABOLIC SYNDROME;
   DANIO-RERIO; FOOD-INTAKE; GASTROINTESTINAL MELATONIN; MELANOCORTIN
   SYSTEM; CLINICAL-RELEVANCE; OXIDATIVE STRESS; OB/OB MICE
AB PurposeOverweight and obesity are important risk factors for diabetes, cardiovascular diseases, and premature death in modern society. Recently, numerous natural and synthetic compounds have been tested in diet-induced obese animal models, to counteract obesity. Melatonin is a circadian hormone, produced by pineal gland and extra-pineal sources, involved in processes which have in common a rhythmic expression. In teleost, it can control energy balance by activating or inhibiting appetite-related peptides. The study aims at testing effects of melatonin administration to control-fed and overfed zebrafish, in terms of expression levels of orexigenic (Ghrelin, orexin, NPY) and anorexigenic (leptin, POMC) genes expression and morphometry of visceral and subcutaneous fat depots.MethodsAdult male zebrafish (n=56) were divided into four dietary groups: control, overfed, control+melatonin, overfed+melatonin. The treatment lasted 5 weeks and BMI levels of every fish were measured each week. After this period fishes were sacrificed; morphological and morphometric studies have been carried out on histological sections of adipose tissue and adipocytes. Moreover, whole zebrafish brain and intestine were used for qRT-PCR.ResultsOur results demonstrate that melatonin supplementation may have an effect in mobilizing fat stores, in increasing basal metabolism and thus in preventing further excess fat accumulation. Melatonin stimulates the anorexigenic and inhibit the orexigenic signals.ConclusionsIt seems that adequate melatonin treatment exerts anti-obesity protective effects, also in a diet-induced obesity zebrafish model, that might be the result of the restoration of many factors: the final endpoint reached is weight loss and stabilization of weight gain.
C1 [Montalbano, G.; Mania, M.; Abbate, F.; Guerrera, M. C.; Laura, R.; Levanti, M.; Germana, A.] Univ Messina, Dept Vet Sci, Polo Univ SS Annunziata, I-98168 Messina, Italy.
   [Montalbano, G.; Abbate, F.; Guerrera, M. C.; Levanti, M.; Germana, A.] Univ Messina, Zebrafish Neuromorphol Lab, Polo Univ SS Annunziata, I-98168 Messina, Italy.
   [Navarra, M.] Univ Messina, Dept Drug Sci & Prod Hlth, Polo Univ SS Annunziata, I-98168 Messina, Italy.
   [Vega, J. A.] Univ Oviedo, Dept Morfol & Biol Celular, E-33006 Oviedo, Spain.
   [Vega, J. A.] Univ Autonoma Chile, Fac Ciencias Salud, 5 Poniente 1670, Talca, Chile.
C3 University of Messina; University of Messina; University of Messina;
   University of Oviedo; Universidad Autonoma de Chile
RP Montalbano, G (corresponding author), Univ Messina, Dept Vet Sci, Polo Univ SS Annunziata, I-98168 Messina, Italy.; Montalbano, G (corresponding author), Univ Messina, Zebrafish Neuromorphol Lab, Polo Univ SS Annunziata, I-98168 Messina, Italy.
EM gmontalbano@unime.it
RI Germana, Antonino/AAH-2505-2020; Vega, Jose/AAG-3209-2021; Mania,
   Manuela/E-5738-2018
OI MONTALBANO, GIUSEPPE/0000-0002-8195-4986; Navarra,
   Michele/0000-0002-6492-7820; Mania, Manuela/0000-0001-5144-8719;
   Germana, Antonino/0000-0003-0934-3619
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Z9 40
U1 1
U2 41
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1355-008X
EI 1559-0100
J9 ENDOCRINE
JI Endocrine
PD NOV
PY 2018
VL 62
IS 2
BP 381
EP 393
DI 10.1007/s12020-018-1653-x
PG 13
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA GZ3SN
UT WOS:000449306400014
PM 29926348
DA 2025-06-11
ER

PT J
AU Roberts, HM
   Grant, MM
   Hubber, N
   Super, P
   Singhal, R
   Chapple, ILC
AF Roberts, Helen M.
   Grant, Melissa M.
   Hubber, Naomi
   Super, Paul
   Singhal, Rishi
   Chapple, Iain L. C.
TI Impact of Bariatric Surgical Intervention on Peripheral Blood Neutrophil
   (PBN) Function in Obesity
SO OBESITY SURGERY
LA English
DT Article
DE Chemotaxis; Glycated haemoglobin (HbA1c); Neutrophil extracellular traps
   (NETs); Peripheral blood neutrophil (PBN); Reactive oxygen species
   (ROS); Very low-calorie diet (VLCD); Cytokines
ID INCREASED OXIDATIVE STRESS; TUMOR-NECROSIS-FACTOR; LOW-CALORIE DIET;
   WEIGHT-LOSS; EXTRACELLULAR TRAPS; METABOLIC SYNDROME; INFLAMMATION;
   DYSFUNCTION; APOPTOSIS; TISSUE
AB The aim of this study was to investigate the impact of weight loss following gastric band surgery on multiple measures of peripheral blood neutrophil (PBN) function.
   Twenty-three obese patients undergoing gastric band surgery were recruited to a longitudinal intervention study, alongside non-obese, healthy gender- and age-matched controls. Eighteen pairs of patients and controls completed all stages of the study. PBNs were isolated by density centrifugation and a comprehensive analysis of PBN function was undertaken at various stages of the patients' bariatric surgical care pathway.
   Obese patients exhibited exaggerated PBN activity in response to various stimuli, characterised by higher reactive oxygen species (ROS) generation (n = 18, p < 0.001) and release of pro-inflammatory cytokines (n = 10, p < 0.05) and lower PBN extracellular trap (NET) formation (n = 18, p < 0.01). PBN chemotactic accuracy was also impaired prior to surgery (n = 18, p < 0.01). Weight loss was associated with normalised NET production and lower ROS production and cytokine release relative to healthy controls. However, chemotactic accuracy remained impaired in patients.
   Weight loss following gastric band surgery was associated with a decrease in the pro-inflammatory activities of peripheral blood neutrophils (PBNs). A hyper-inflammatory PBN phenotype, involving excess ROS and cytokine release, reduced NET formation and chemotaxis, may lead to a reduced ability to eliminate infection, alongside inflammation-mediated tissue damage in obese individuals.
C1 [Roberts, Helen M.; Grant, Melissa M.; Hubber, Naomi; Chapple, Iain L. C.] Univ Birmingham, Inst Clin Sci, Sch Dent, Periodontal Res Grp, 5 Mill Pool Way, Birmingham B5 7ET, W Midlands, England.
   [Roberts, Helen M.; Grant, Melissa M.; Hubber, Naomi; Chapple, Iain L. C.] Birmingham Community Healthcare Trust, Birmingham Dent Hosp, 5 Mill Pool Way, Birmingham B5 7ET, W Midlands, England.
   [Super, Paul; Singhal, Rishi] Birmingham Heartlands Hosp, Birmingham B9 5SS, W Midlands, England.
C3 University of Birmingham; University of Birmingham; University of
   Birmingham; Heart of England NHS Foundation Trust; Heartlands Hospital
RP Grant, MM (corresponding author), Univ Birmingham, Inst Clin Sci, Sch Dent, Periodontal Res Grp, 5 Mill Pool Way, Birmingham B5 7ET, W Midlands, England.; Grant, MM (corresponding author), Birmingham Community Healthcare Trust, Birmingham Dent Hosp, 5 Mill Pool Way, Birmingham B5 7ET, W Midlands, England.
EM m.m.grant@bham.ac.uk
RI Büyükkasap, Çağrı/AAA-9276-2020; Roberts, Helen/I-1041-2012; Grant,
   Melissa/A-5590-2010; Chapple, Iain/T-2986-2017
OI Grant, Melissa/0000-0003-1154-7266; Chapple, Iain/0000-0003-2697-7082
FU Medical Research Council [MR/J500434/1]
FX This work was supported by the Medical Research Council (Grant Number
   MR/J500434/1).
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   2013, WORLD HLTH REP 2000, P1
NR 61
TC 29
Z9 30
U1 0
U2 2
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0960-8923
EI 1708-0428
J9 OBES SURG
JI Obes. Surg.
PD JUN
PY 2018
VL 28
IS 6
BP 1611
EP 1621
DI 10.1007/s11695-017-3063-1
PG 11
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA GH6HD
UT WOS:000433544000021
PM 29238916
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Conceiçao, EPS
   Kaezer, AR
   Peixoto-Silva, N
   Felzenszwalb, I
   de Oliveira, E
   Moura, EG
   Lisboa, PC
AF Conceicao, E. P. S.
   Kaezer, A. R.
   Peixoto-Silva, N.
   Felzenszwalb, I.
   de Oliveira, E.
   Moura, E. G.
   Lisboa, P. C.
TI Effects of Ilex paraguariensis (yerba mate) on the hypothalamic
   signalling of insulin and leptin and liver dysfunction in adult rats
   overfed during lactation
SO JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE
LA English
DT Article
DE fat liver; Ilex paraguariensis; insulin; leptin; programming
ID POSTNATAL EARLY OVERNUTRITION; METABOLIC SYNDROME; OBESITY; ANTIOXIDANT;
   EXTRACT; CHOLESTEROL; RESISTANCE; CALCIUM; MODEL; YOUNG
AB Ilex paraguariensis (yerba mate) has a beneficial effect in the management of obesity. Here, we studied the effects of yerba mate on hypothalamic changes in leptin and insulin signalling, oxidative stress and liver morphology and metabolism in postnatal early overfeeding (EO) Wistar rats. To induce EO, the litter size was reduced to three pups per dam, and litters with 10 pups per dam were used as a control (10 litters each). On postnatal day (PN) 150, EO offspring were subdivided into EO and EO+mate groups (10 animals each), which were treated with water or mate tea [1 g/kg body weight (BW)/day, by gavage], respectively, for 30 days. The C offspring received water. On PN180, yerba mate treatment prevented BW gain and reduced total body fat, visceral fat and food intake in comparison with the EO group. Leptin and insulin signalling in the hypothalamus measured by Western blotting was reduced only in the EO group. Yerba mate treatment had a greater impact on insulin signalling normalization. In the liver, yerba mate treatment normalized antioxidant enzyme activities and, consequently, decreased lipid peroxidation, determined by malondialdehyde content. In addition, the steatosis level and the liver triglyceride content were also restored. Thus, for the first time, yerba mate was demonstrated to increase antioxidant defences and improve liver metabolism in adult rats that were overfed during lactation, possibly through improvements in the hypothalamic action of insulin. These findings may be important for the treatment of obesity-related disorders.
C1 [Conceicao, E. P. S.; Kaezer, A. R.; Peixoto-Silva, N.; de Oliveira, E.; Moura, E. G.; Lisboa, P. C.] Univ Estado Rio De Janeiro, Roberto Alcantara Gomes Biol Inst, Dept Physiol Sci, Rio De Janeiro, RJ, Brazil.
   [Kaezer, A. R.; Felzenszwalb, I.] Univ Estado Rio De Janeiro, Roberto Alcantara Gomes Biol Inst, Dept Biophys & Biometry, Rio De Janeiro, RJ, Brazil.
C3 Universidade do Estado do Rio de Janeiro; Universidade do Estado do Rio
   de Janeiro
RP Lisboa, PC (corresponding author), Univ Estado Rio de Janeiro, Dept Ciencias Fisiol, Inst Biol, 5 Andar,Av 28 Setembro,87, BR-20551031 Rio De Janeiro, RJ, Brazil.
EM pclisboa@uerj.br
RI Peixoto-Silva, Nayara/P-5072-2015; Felzenszwalb, Israel/AAH-4915-2020;
   Moura, Egberto/H-1270-2012; Lisboa, Patricia/H-8336-2015
OI Moura, Egberto/0000-0002-1159-7549; Conceicao Furber,
   Ellen/0000-0003-0370-1032; Lisboa, Patricia/0000-0002-2477-4364
FU National Council for Scientific and Technological Development (Conselho
   Nacional de Desenvolvimento Cientifico e Tecnologico - CNPq); State of
   Rio de Janeiro Carlos Chagas Filho Research Foundation (Fundacao Carlos
   Chagas Filho de Amparo a Pesquisa do Estado do Rio de Janeiro - FAPERJ)
FX This research was supported by the National Council for Scientific and
   Technological Development (Conselho Nacional de Desenvolvimento
   Cientifico e Tecnologico - CNPq), and the State of Rio de Janeiro Carlos
   Chagas Filho Research Foundation (Fundacao Carlos Chagas Filho de Amparo
   a Pesquisa do Estado do Rio de Janeiro - FAPERJ).
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NR 49
TC 14
Z9 15
U1 0
U2 8
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 2040-1744
EI 2040-1752
J9 J DEV ORIG HLTH DIS
JI J. Dev. Orig. Health Dis.
PD FEB
PY 2017
VL 8
IS 1
BP 123
EP 132
DI 10.1017/S2040174416000519
PG 10
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA EK1HK
UT WOS:000393676200011
PM 27609670
DA 2025-06-11
ER

PT J
AU Gaillard, TR
   Osei, K
AF Gaillard, Trudy R.
   Osei, Kwame
TI Racial Disparities in the Pathogenesis of Type 2 Diabetes and its
   Subtypes in the African Diaspora: A New Paradigm
SO JOURNAL OF RACIAL AND ETHNIC HEALTH DISPARITIES
LA English
DT Article
DE Type 2 diabetes; Ketosis-prone diabetes; Insulin resistance; Insulin
   secretion; African Diaspora
ID IMPAIRED GLUCOSE-TOLERANCE; C-REACTIVE PROTEIN; SERUM ADIPONECTIN
   LEVELS; BETA-CELL DYSFUNCTION; NON-HISPANIC WHITES; INSULIN SENSITIVITY;
   ETHNIC-DIFFERENCES; METABOLIC SYNDROME; ATHEROSCLEROSIS RISK; FASTING
   TRIGLYCERIDE
AB The global epidemic of diabetes has extended to the developing countries including Sub-Sahara Africa. In this context, blacks with type 2 diabetes in the African Diaspora continue to manifest 1.5-2 times higher prevalent rates than in their white counterparts. Previous studies have demonstrated that blacks with and without type 2 diabetes have alterations in hepatic and peripheral insulin sensitivity, beta-cell function, and hepatic insulin clearance as well as hepatic glucose dysregulation when compared to whites. In addition, non-diabetic blacks in the African Diaspora manifest multiple metabolic mediators that predict type 2 diabetes and its subtypes. These pathogenic modifiers include differences in subclinical inflammation, oxidative stress burden, and adipocytokines in blacks in the African Diaspora prior to clinical diagnosis. Consequently, blacks in the African Diaspora manifest subtypes of type 2 diabetes, including ketosis-prone diabetes and J type diabetes. Given the diversity of type 2 diabetes in blacks in the African Diaspora, we hypothesize that blacks manifest multiple early pathogenic defects prior to the diagnosis of type 2 diabetes and its subtypes. These metabolic alterations have strong genetic component, which appears to play pivotal and primary role in the pathogenesis of type 2 diabetes and its subtypes in blacks in the African Diaspora. However, environmental factors must also be considered as major contributors to the higher prevalence of type 2 diabetes and its subtypes in blacks in the African Diaspora. These multiple alterations should be targets for early prevention of type 2 diabetes in blacks in the African Diaspora.
C1 [Gaillard, Trudy R.] Ohio State Univ, Div Endocrinol Diabet & Metab, Wexner Med Ctr, 561 McCampbell Hall South,1581 Dodd Dr, Columbus, OH 43210 USA.
   [Osei, Kwame] Ohio State Univ, Wexner Med Ctr, 561 McCampbell Hall,5th Floor South, Columbus, OH 43210 USA.
C3 University System of Ohio; Ohio State University; University System of
   Ohio; Ohio State University
RP Gaillard, TR (corresponding author), Ohio State Univ, Div Endocrinol Diabet & Metab, Wexner Med Ctr, 561 McCampbell Hall South,1581 Dodd Dr, Columbus, OH 43210 USA.
EM trudy.gaillard@uc.edu; kwame.osei@osumc.edu
FU NCRR NIH HHS [UL1 RR025755] Funding Source: Medline
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NR 76
TC 9
Z9 10
U1 0
U2 4
PU SPRINGER INTERNATIONAL PUBLISHING AG
PI CHAM
PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND
SN 2197-3792
EI 2196-8837
J9 J RACIAL ETHN HEALTH
JI J. Racial Ethn. Health Disparities
PD MAR
PY 2016
VL 3
IS 1
BP 117
EP 128
DI 10.1007/s40615-015-0121-z
PG 12
WC Public, Environmental & Occupational Health
WE Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA DT5FU
UT WOS:000381507800012
PM 26896111
DA 2025-06-11
ER

PT J
AU Yang, JH
   Chou, CH
   Yang, WS
   Ho, HN
   Yang, YS
   Chen, MJ
AF Yang, Jehn-Hsiahn
   Chou, Chia-Hung
   Yang, Wei-Shiung
   Ho, Hong-Nerng
   Yang, Yu-Shih
   Chen, Mei-Jou
TI Iron stores and obesity are negatively associated with ovarian volume
   and anti-Mullerian hormone levels in women with polycystic ovary
   syndrome
SO TAIWANESE JOURNAL OF OBSTETRICS & GYNECOLOGY
LA English
DT Article
DE anti-Mullerian hormone; ferritin; iron stores; obesity; ovarian volume
ID SERUM ANTIMULLERIAN HORMONE; BETA-THALASSEMIA MAJOR; ANTRAL FOLLICLE
   COUNT; FATTY LIVER-DISEASE; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   DIABETES-MELLITUS; GRANULOSA-CELLS; YOUNG-WOMEN; AGE
AB Objective: Obesity and insulin resistance are associated with increased iron stores, but have conflicting effects on ovarian reserve in women with polycystic ovary syndrome (PCOS). Iron-catalyzed oxidative stress might be detrimental to ovarian tissue and granulosa cell function. In this study we determined the association between body iron stores, obesity, and ovarian reserve in women with PCOS.
   Materials and Methods: One hundred and fifty-six women diagnosed with PCOS according to Rotterdam criteria and 30 normoweight healthy control women were enrolled in this cross-sectional study. Ovarian volume, total antral follicle count, and the anti-Mullerian hormone (AMH) level were measured as an indicator of ovarian reserve.
   Results: Ferritin and transferrin-bound iron levels were significantly higher in women with PCOS than normoweight controls. Obese women with PCOS had higher ferritin levels (p = 0.006), but lower AMH levels (p < 0.0001) than nonobese women with PCOS. Using univariate analysis, the AMH level and mean ovarian volume were inversely related to the ferritin level, homeostasis model assessment of insulin resistance, and body mass index in women with PCOS. Body mass index and ferritin level remained significantly correlated with a lower AMH level and reduced ovarian volume, respectively, after considering other confounding variables.
   Conclusion: An elevated ferritin level and obesity were negatively associated with ovarian volume and the AMH level, respectively, in women with PCOS. Copyright (C) 2015, Taiwan Association of Obstetrics & Gynecology. Published by Elsevier Taiwan LLC. All rights reserved.
C1 [Yang, Jehn-Hsiahn; Chou, Chia-Hung; Ho, Hong-Nerng; Yang, Yu-Shih; Chen, Mei-Jou] Natl Taiwan Univ, Dept Obstet, Taipei 10764, Taiwan.
   [Yang, Jehn-Hsiahn; Chou, Chia-Hung; Ho, Hong-Nerng; Yang, Yu-Shih; Chen, Mei-Jou] Natl Taiwan Univ, Dept Gynecol, Taipei 10764, Taiwan.
   [Yang, Wei-Shiung] Natl Taiwan Univ, Natl Taiwan Univ Hosp, Internal Med, Taipei 10764, Taiwan.
   [Yang, Wei-Shiung] Natl Taiwan Univ, Coll Med, Grad Inst Clin Med, Taipei 10764, Taiwan.
C3 National Taiwan University; National Taiwan University; National Taiwan
   University; National Taiwan University Hospital; National Taiwan
   University
RP Chen, MJ (corresponding author), Natl Taiwan Univ Hosp, Dept Obstet, 7 Chung Shan South Rd, Taipei 100, Taiwan.; Chen, MJ (corresponding author), Natl Taiwan Univ Hosp, Dept Gynecol, 7 Chung Shan South Rd, Taipei 100, Taiwan.
EM mjchen04@ntu.edu.tw
RI NTU, Ref07/AAX-7890-2021; Chen, Mei-Jou/AAS-7698-2020
OI CHEN, MEI-JOU/0000-0002-2305-1105; Ho, Hong-Nerng/0000-0002-7207-0089;
   YANG, YU-SHIH/0000-0002-8633-0873; YANG,
   JEHN-HSIAHN/0000-0001-8648-0882; YANG, WEI-SHIUNG/0000-0001-5087-373X
FU National Science Council of Taiwan [NSC 97-2314-8002-079-MY3,
   NSC98-2314-B002-105-MY3, NSC 100-2314-B002-027-MY3]
FX This study was supported by grants NSC 97-2314-8002-079-MY3,
   NSC98-2314-B002-105-MY3, and NSC 100-2314-B002-027-MY3 from the National
   Science Council of Taiwan.
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NR 50
TC 19
Z9 20
U1 0
U2 7
PU ELSEVIER TAIWAN
PI TAIPEI
PA RM N-412, 4F, CHIA HSIN BUILDING 11, NO 96, ZHONG SHAN N ROAD SEC 2,
   TAIPEI, 10449, TAIWAN
SN 1028-4559
J9 TAIWAN J OBSTET GYNE
JI Taiwan. J. Obstet. Gynecol.
PD DEC
PY 2015
VL 54
IS 6
BP 686
EP 692
DI 10.1016/j.tjog.2014.11.025
PG 7
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA DD1JT
UT WOS:000369678700011
PM 26700986
OA gold
DA 2025-06-11
ER

PT J
AU Stenvinkel, P
AF Stenvinkel, Peter
TI Obesity-a disease with many aetiologies disguised in the same oversized
   phenotype: has the overeating theory failed?
SO NEPHROLOGY DIALYSIS TRANSPLANTATION
LA English
DT Review
DE epigenome; gut microbiota; insulin resistance; mitochondria; obesity
ID BODY-MASS INDEX; URIC-ACID; OXIDATIVE STRESS; INSULIN SENSITIVITY;
   METABOLIC SYNDROME; HIGH-FAT; EPIGENETIC REGULATION; ADIPOSE-TISSUE;
   FOOD-INTAKE; FRUCTOSE
AB Evolution has led to metabolic thrift in humans-a genetic heritage that, when exposed to the modern 'obesogenic' milieu with energy-dense food and a sedentary lifestyle, predisposes to obesity. The current paradigm that overeating of easily digestible carbohydrates and the resulting imbalance between energy in and out as the cause of overweight has recently been challenged. Indeed, studies suggest that the host response to various nutrients contributes to overeating and fat accumulation. Alterations in neurotransmitter functions, changes in the epigenome, dysbiosis of gut microbiota and effects of specific nutrients (or lack of such nutrients) on mitochondrial function and signalling pathways may promote fat accumulation independent of calories. Whereas nutrients that stimulate generation of uric acid (such as fructose and purine-rich food) cause insulin resistance and fat accumulation, other nutrients (such as antioxidants, plant food, probiotics, nuts, soy and omega-3) counteract the negative effects of a calorie-rich diet by salutary effects on mitochondrial biogenesis. Thus, the specific metabolic effects of different nutrients may be more important than its total energy content. By studying the impact of nutrients on mitochondrial health, as well as the trans-generational impact of nutrients during fetal life, and how specific bacterial species correlate with fat mass accumulation, new dietary targets for obesity management may emerge. Overeating and overshooting of calories could to a large extent represent a symptom rather than a cause of obesity; therefore, hypocaloric diets should probably not be the main, and certainly not the only, focus for treatment of the obese patient.
C1 Karolinska Inst, Div Renal Med, Dept Clin Sci Intervent & Technol, Stockholm, Sweden.
C3 Karolinska Institutet
RP Stenvinkel, P (corresponding author), Karolinska Inst, Div Renal Med, Dept Clin Sci Intervent & Technol, Stockholm, Sweden.
EM peter.stenvinkel@ki.se
OI Stenvinkel, Peter/0000-0002-8785-4820
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NR 100
TC 26
Z9 34
U1 0
U2 27
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0931-0509
EI 1460-2385
J9 NEPHROL DIAL TRANSPL
JI Nephrol. Dial. Transplant.
PD OCT
PY 2015
VL 30
IS 10
BP 1656
EP 1664
DI 10.1093/ndt/gfu338
PG 10
WC Transplantation; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Transplantation; Urology & Nephrology
GA CT9YG
UT WOS:000363171900009
PM 25361999
DA 2025-06-11
ER

PT J
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   Yubero, S
AF Olea, Elena
   Teresa Agapito, Maria
   Gallego-Martin, Teresa
   Rocher, Asuncion
   Gomez-Nino, Angela
   Obeso, Ana
   Gonzalez, Constancio
   Yubero, Sara
TI Intermittent hypoxia and diet-induced obesity: effects on oxidative
   status, sympathetic tone, plasma glucose and insulin levels, and
   arterial pressure
SO JOURNAL OF APPLIED PHYSIOLOGY
LA English
DT Article
DE intermittent hypoxia; oxidative stress; sympathetic activity; insulin
   resistance; hypertension
ID OBSTRUCTIVE SLEEP-APNEA; CAROTID-BODY; BLOOD-PRESSURE; CARDIOVASCULAR
   CONSEQUENCES; THERAPEUTIC TARGET; METABOLIC SYNDROME; EPISODIC HYPOXIA;
   OXYGEN; RESISTANCE; CHEMORECEPTOR
AB Obstructive sleep apnea (OSA) consists of sleep-related repetitive obstructions of upper airways that generate episodes of recurrent or intermittent hypoxia (IH). OSA commonly generates cardiovascular and metabolic pathologies defining the obstructive sleep apnea syndrome (OSAS). Literature usually links OSA-associated pathologies to IH episodes that would cause an oxidative status and a carotid body-mediated sympathetic hyperactivity. Because cardiovascular and metabolic pathologies in obese patients and those with OSAS are analogous, we used models (24-wk-old Wistar rats) of IH (applied from weeks 22 to 24) and diet-induced obesity (O; animals fed a high-fat diet from weeks 12 to 24) to define the effect of each individual maneuver and their combination on the oxidative status and sympathetic tone of animals, and to quantify cardiovascular and metabolic parameters and their deviation from normality. We found that IH and O cause an oxidative status (increased lipid peroxides and diminished activities of superoxide dismutases), an inflammatory status (augmented C-reactive protein and nuclear factor kappa-B activation), and sympathetic hyperactivity (augmented plasma and renal artery catecholamine levels and synthesis rate); combined treatments worsened those alterations. IH and O augmented liver lipid content and plasma cholesterol, triglycerides, leptin, glycemia, insulin levels, and HOMA index, and caused hypertension; most of these parameters were aggravated when IH and O were combined. IH diminished ventilatory response to hypoxia, and hypercapnia and O created a restrictive ventilatory pattern; a combination of treatments led to restrictive hypoventilation. Data demonstrate that IH and O cause comparable metabolic and cardiovascular pathologies via misregulation of the redox status and sympathetic hyperactivity.
C1 [Gonzalez, Constancio] Univ Valladolid, Sch Med, Dept Biochem & Mol Biol & Physiol, E-47005 Valladolid, Spain.
   Inst Salud Carlos III, CIBERES, CIBER Enfermedades Resp, Inst Mol Biol & Genet, Valladolid, Spain.
C3 Universidad de Valladolid; Consejo Superior de Investigaciones
   Cientificas (CSIC); CSIC-UVA - Instituto de Biologia y Genetica
   Molecular (IBGM); Instituto de Salud Carlos III; Consejo Superior de
   Investigaciones Cientificas (CSIC); CSIC-UVA - Instituto de Biologia y
   Genetica Molecular (IBGM); CIBER - Centro de Investigacion Biomedica en
   Red; CIBERES
RP Gonzalez, C (corresponding author), Univ Valladolid, Sch Med, Dept Biochem & Mol Biol & Physiol, E-47005 Valladolid, Spain.
EM constanc@ibgm.uva.es
RI Benito, Sara/H-9247-2015; Agapito, Teresa/I-1682-2015; Gallego Martin,
   Teresa/JOJ-9983-2023; Olea, Elena/S-4214-2018; ROCHER,
   Asuncion/H-5411-2012; Gomez-Nino, Angela/C-4784-2013; Obeso,
   Ana/H-9282-2015
OI Gallego-Martin, Teresa/0000-0001-9096-4003; Rocher, M.
   Asuncion/0000-0001-9043-0474; Olea, Elena/0000-0002-5128-0036;
   Gomez-Nino, Angela/0000-0002-5240-2410; Obeso, Ana/0000-0003-3197-1697
FU Spanish Ministry of Economy and Competitiveness [BFU2012-37459]; Spanish
   Ministry of Health-Institute Carlos III Grant [CIBER CB06/06/0050]
FX Support for this study was provided by Spanish Ministry of Economy and
   Competitiveness Grant BFU2012-37459 and Spanish Ministry of
   Health-Institute Carlos III Grant CIBER CB06/06/0050 to C.G.
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NR 72
TC 65
Z9 77
U1 0
U2 33
PU AMER PHYSIOLOGICAL SOC
PI Rockville
PA 6120 Executive Blvd, Suite 600, Rockville, MD, UNITED STATES
SN 8750-7587
EI 1522-1601
J9 J APPL PHYSIOL
JI J. Appl. Physiol.
PD OCT 1
PY 2014
VL 117
IS 7
BP 706
EP 719
DI 10.1152/japplphysiol.00454.2014
PG 14
WC Physiology; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology; Sport Sciences
GA AR0DQ
UT WOS:000343237500005
PM 25103975
DA 2025-06-11
ER

PT J
AU Adinolfi, LE
   Restivo, L
   Marrone, A
AF Adinolfi, Luigi E.
   Restivo, Luciano
   Marrone, Aldo
TI The predictive value of steatosis in hepatitis C virus infection
SO EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY
LA English
DT Article
DE atherosclerosis; HCV; hepatocellular carcinoma; insulin resistance;
   liver fibrosis; steatosis
ID TRIGLYCERIDE TRANSFER PROTEIN; HCV GENOTYPE 3; INSULIN-RESISTANCE;
   HEPATOCELLULAR-CARCINOMA; CORE PROTEIN; FIBROSIS PROGRESSION; ANTIVIRAL
   TREATMENT; OXIDATIVE STRESS; LIVER STEATOSIS; LOW-DENSITY
AB Steatosis is a complication of hepatitis C virus (HCV) infection and the mechanisms of its development are complex, involving viral and host factors. Steatosis that is prevalently viral is associated with HCV genotype 3, and steatosis that is prevalently metabolic is associated with non-3 genotypes. Viral steatosis is correlated with the level of HCV replication, whereas metabolic steatosis is related to insulin resistance. The two types of steatosis have a different impact on HCV disease and may have an additive effect. HCV infection is a multifaceted disease with hepatic and extrahepatic manifestations. There is a body of evidence indicating that HCV-related steatosis plays a role in many HCV manifestations and, thus, the presence of steatosis is a predictive factor for the development of such events. The current data show that HCV-related steatosis predicts an advanced liver disease and a more rapid progression of fibrosis, as well as an increased risk of development of hepatocellular carcinoma. Moreover, the presence of steatosis in a HCV patient has a high predictive value that the subject may have or may develop insulin resistance, diabetes and metabolic syndrome. Recently, a strict association between HCV-related steatosis and development of atherosclerosis has been demonstrated. In addition, steatosis negatively impacts response rate to interferon-based treatment, even in HCV genotype-3 infection. Therapeutic strategies to improve steatosis and, consequently, response to standard antiviral therapy and outcome of disease are wanted. The authors summarize current knowledge of impact of steatosis on the above reported clinical conditions associated with HCV infection.
C1 [Adinolfi, Luigi E.; Restivo, Luciano; Marrone, Aldo] Univ Naples 2, Dept Med Surg Neurol Geriatr & Metab Dis, Internal Med Clin Hosp Marcianise, ASL Caserta, Naples, Italy.
C3 Universita della Campania Vanvitelli
RP Adinolfi, LE (corresponding author), Univ Naples 2, Dept Med Surg Neurol Geriatr & Metab Dis, Internal Med Clin Hosp Marcianise, ASL Caserta, Naples, Italy.
EM luigielio.adinolfi@unina2.it
RI Marrone, Aldo/AAH-3614-2020
OI MARRONE, Aldo/0000-0001-7329-4159
FU Regione Campania, Italy
FX The work was supported by a grant from Regione Campania, Italy. The
   authors have no other relevant affiliations or financial involvement
   with any organization or entity with a financial interest in or
   financial conflict with the subject matter or materials discussed in the
   manuscript apart from those disclosed.
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NR 67
TC 22
Z9 23
U1 0
U2 10
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1747-4124
EI 1747-4132
J9 EXPERT REV GASTROENT
JI Expert Rev. Gastroenterol. Hepatol.
PD MAR
PY 2013
VL 7
IS 3
BP 205
EP 213
DI 10.1586/EGH.13.7
PG 9
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 098XW
UT WOS:000315583400009
PM 23445230
DA 2025-06-11
ER

PT J
AU Barg, E
   Szopa, J
   Pesz, KA
   Gasiorowski, K
AF Barg, Ewa
   Szopa, Jan
   Pesz, Karolina A.
   Gasiorowski, Kazimierz
TI Indices of Insulin Resistance and Dyslipidemia Are Correlated with
   Lymphocyte Proneness to Apoptosis in Obese or Overweight Low Birth
   Weight Children
SO HORMONE RESEARCH IN PAEDIATRICS
LA English
DT Article
DE Low birth weight children; Insulin resistance; Apoptosis; Pulsed-field
   gel electrophoresis
ID FOR-GESTATIONAL-AGE; OXIDATIVE STRESS; DIABETES-MELLITUS; P53; GROWTH;
   BORN; DNA; CONSEQUENCES; HYPERTENSION; ACTIVATION
AB Aims: Our aim was to study the relationship between markers of cell proneness to apoptosis and indices of insulin resistance and dyslipidemia in children born with low birth weight (LBW). Methods: The study comprised 177 prepubertal children stratified by birth weight and their nutritional status into LBW (n = 138) and normal birth weight (NBW; n = 39) groups. We analyzed DNA from peripheral blood lymphocytes, separated by pulsed-field gel electrophoresis (PFGE), as well as the serum levels of cholesterol, HDL-cholesterol, triglycerides, fasting insulin and glucose, caspase 3, and BCL2. Results: LBW children with a BMI SDS > 1.55 demonstrated increased content of the large fragments of the lymphocyte DNA [300-500 kb (DNA 300-500 kb)] in electrophoretic slides (a marker of decreased chromatin stability and susceptibility of cells to apoptosis) compared to the NBW group. In these children the level of DNA 300-500 kb exhibited a strong negative correlation with the serum level of antiapoptotic protein of BCL2 (r = -0.901). DNA 300-500 kb significantly correlated with calculated indices of insulin resistance: HOMA-IR and QUICKI as well as with the indices of lipid homeostasis (Castelli and AIP). Conclusions: Increased susceptibility of lymphocytes to apoptosis correlated with a higher risk of insulin resistance and lipid disturbance in overweight or obese LBW children. A comprehensive study of the proneness of cells to apoptosis should be implemented to further investigate the pathomechanism of the metabolic syndrome in these children. Copyright (C) 2013 S. Karger AG, Basel
C1 [Barg, Ewa; Gasiorowski, Kazimierz] Wroclaw Med Univ, Dept Basic Med Sci, PL-50556 Wroclaw, Poland.
   [Pesz, Karolina A.] Wroclaw Med Univ, Dept Genet, PL-50556 Wroclaw, Poland.
   [Szopa, Jan] Univ Wroclaw, Lab Genet Biochem, Fac Biotechnol, PL-50138 Wroclaw, Poland.
C3 Wroclaw Medical University; Wroclaw Medical University; University of
   Wroclaw
RP Barg, E (corresponding author), Wroclaw Med Univ, Dept Basic Med Sci, Ul Borowska 211, PL-50556 Wroclaw, Poland.
EM ebarg@dilnet.wroc.pl
OI Pesz, Karolina/0000-0003-1482-1021
FU Wroclaw Medical University, Poland [KB-483/2003, KB 1024/2005, KB
   618/2008]
FX The authors would like to thank Prof. Beverly M.K. Biller from Harvard
   Medical School, Boston, Mass., USA, and Massachusetts General Hospital,
   and Maria Koltowska-Haggstrom MD, PhD for valuable suggestions. This
   study was supported by grants (Nr: KB-483/2003; KB 1024/2005; KB
   618/2008) from Wroclaw Medical University, Poland.
CR Aldrighi JM, 2004, CONTRACEPTION, V69, P395, DOI 10.1016/j.contraception.2004.01.005
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NR 32
TC 1
Z9 1
U1 0
U2 5
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1663-2818
J9 HORM RES PAEDIAT
JI Horm. Res. Paediatr.
PY 2013
VL 79
IS 5
BP 293
EP 299
DI 10.1159/000351012
PG 7
WC Endocrinology & Metabolism; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Pediatrics
GA 219WH
UT WOS:000324541500005
PM 23689125
DA 2025-06-11
ER

PT J
AU Prudente, S
   Sesti, G
   Pandolfi, A
   Andreozzi, F
   Consoli, A
   Trischitta, V
AF Prudente, Sabrina
   Sesti, Giorgio
   Pandolfi, Assunta
   Andreozzi, Francesco
   Consoli, Agostino
   Trischitta, Vincenzo
TI The Mammalian Tribbles Homolog TRIB3, Glucose Homeostasis, and
   Cardiovascular Diseases
SO ENDOCRINE REVIEWS
LA English
DT Review
ID INSULIN-RECEPTOR SUBSTRATE-1; ENDOPLASMIC-RETICULUM STRESS; SUPPRESSES
   ADIPOCYTE DIFFERENTIATION; FUNCTIONAL Q84R POLYMORPHISM; REDUCED AKT
   PHOSPHORYLATION; CORONARY-HEART-DISEASE; METABOLIC SYNDROME; TRB3
   EXPRESSION; SKELETAL-MUSCLE; NITRIC-OXIDE
AB Insulin signaling plays a physiological role in traditional insulin target tissues controlling glucose homeostasis as well as in pancreatic beta-cells and in the endothelium. Insulin signaling abnormalities may, therefore, be pathogenic for insulin resistance, impaired insulin secretion, endothelial dysfunction, and eventually, type 2 diabetes mellitus (T2DM) and cardiovascular disease. Tribbles homolog 3 (TRIB3) is a 45-kDa pseudokinase binding to and inhibiting Akt, a key mediator of insulin signaling. Akt-mediated effects of TRIB3 in the liver, pancreatic beta-cells, and skeletal muscle result in impaired glucose homeostasis. TRIB3 effects are also modulated by its direct interaction with other signaling molecules. In humans, TRIB3 overactivity, due to TRIB3 overexpression or to Q84R genetic polymorphism, with R84 being a gain-of-function variant, may be involved in shaping the risk of insulin resistance, T2DM, and cardiovascular disease. TRIB3 overexpression has been observed in the liver, adipose tissue, skeletal muscle, and pancreatic beta-cells of individuals with insulin resistance and/or T2DM. The R84 variant has also proved to be associated with insulin resistance, T2DM, and cardiovascular disease. TRIB3 direct effects on the endothelium might also play a role in increasing the risk of atherosclerosis, as indicated by studies on human endothelial cells carrying the R84 variant that are dysfunctional in terms of Akt activation, NO production, and other proatherogenic changes. In conclusion, studies on TRIB3 have un-raveled new molecular mechanisms underlying metabolic and cardiovascular abnormalities. Additional investigations are needed to verify whether such acquired knowledge will be relevant for improving care delivery to patients with metabolic and cardiovascular alterations. (Endocrine Reviews 33: 526-546, 2012)
C1 [Prudente, Sabrina; Trischitta, Vincenzo] Inst Ricovero & Cura Carattere Sci Casa Sollievo, Mendel Lab, I-71013 San Giovanni Rotondo, Italy.
   [Trischitta, Vincenzo] Inst Ricovero & Cura Carattere Sci Casa Sollievo, Res Unit Diabet & Endocrine Dis, I-71013 San Giovanni Rotondo, Italy.
   [Sesti, Giorgio; Andreozzi, Francesco] Magna Graecia Univ Catanzaro, Dept Med & Surg Sci, I-88100 Catanzaro, Italy.
   [Pandolfi, Assunta] Univ G DAnnunzio, Aging Res Ctr, Dept Biomed Sci, Ctr Excellence Aging,G DAnnunzio Univ Fdn, I-66013 Chieti, Italy.
   [Consoli, Agostino] Univ G DAnnunzio, Aging Res Ctr, Dept Med & Aging Sci, Ctr Excellence Aging,G DAnnunzio Univ Fdn, I-66013 Chieti, Italy.
   [Trischitta, Vincenzo] Univ Roma La Sapienza, Dept Expt Med, I-00185 Rome, Italy.
C3 IRCCS Casa Sollievo Della Sofferenza; Istituto CSS Mendel; Magna Graecia
   University of Catanzaro; G d'Annunzio University of Chieti-Pescara; G
   d'Annunzio University of Chieti-Pescara; Sapienza University Rome
RP Trischitta, V (corresponding author), CSS Mendel Inst, Viale Regina Margherita 261, I-00198 Rome, Italy.
EM vincenzo.trischitta@uniroma1.it
RI Sesti, Giorgio/B-1509-2012; Consoli, Agostino/J-8027-2018; TRISCHITTA,
   Vincenzo/K-1487-2016; Prudente, Sabrina/H-2886-2016; Andreozzi,
   Francesco/J-4073-2018; PANDOLFI, Assunta/K-4595-2016
OI TRISCHITTA, Vincenzo/0000-0003-1174-127X; Sesti,
   Giorgio/0000-0002-1618-7688; consoli, agostino/0000-0002-1885-451X;
   Prudente, Sabrina/0000-0001-9220-8981; Andreozzi,
   Francesco/0000-0001-9375-1513; PANDOLFI, Assunta/0000-0003-4135-7631
FU European Foundation for the Study of Diabetes (Sanofi-Aventis Partner
   Program); Italian Ministry of Health (Ricerca Corrente); Italian
   Ministry for the University and Scientific Research; Italian Ministry
   for Agricultural, Nutritional Policies, and Forestry (Special Research
   Grant MiPAAF-CARONUT); European Union [LSHM-CT-2004-512013]
FX The funding for this manuscript is by the European Foundation for the
   Study of Diabetes (Sanofi-Aventis Partner Program 2010 to A.C.).This
   work was partly supported by the Italian Ministry of Health (Ricerca
   Corrente 2011 and 2012 to S. P. and V. T.); by the European Foundation
   for the Study of Diabetes (Sanofi-Aventis Partner Program 2010 to A.
   C.); by the Italian Ministry for the University and Scientific Research
   (PRIN 2008 to A. C.); by the Italian Ministry for Agricultural,
   Nutritional Policies, and Forestry (Special Research Grant
   MiPAAF-CARONUT 2008 to A. P.); and by the European Union (FP6 EUGENE2
   no. LSHM-CT-2004-512013 to G.S.).
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NR 102
TC 91
Z9 107
U1 0
U2 20
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0163-769X
EI 1945-7189
J9 ENDOCR REV
JI Endocr. Rev.
PD AUG
PY 2012
VL 33
IS 4
BP 526
EP 546
DI 10.1210/er.2011-1042
PG 21
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 987IA
UT WOS:000307409200003
PM 22577090
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Ryu, S
   Chang, Y
   Kim, SG
   Cho, J
   Guallar, E
AF Ryu, Seungho
   Chang, Yoosoo
   Kim, Soo-Geun
   Cho, Juhee
   Guallar, Eliseo
TI Serum uric acid levels predict incident nonalcoholic fatty liver disease
   in healthy Korean men
SO METABOLISM-CLINICAL AND EXPERIMENTAL
LA English
DT Article
ID METABOLIC SYNDROME; OXIDATIVE STRESS; INSULIN-RESISTANCE; HYPERURICEMIA;
   PROGRESSION; RISK; ASSOCIATION; HYPOTHESIS; MORTALITY; OBESITY
AB The objective of the study was to assess the prospective association between serum uric acid levels and incident nonalcoholic fatty liver disease in a cohort of healthy Korean men. A cohort study was performed on 5741 Korean men, 30 to 59 years of age, with no evidence of fatty liver disease on liver ultrasound and with no major risk factors for liver disease at baseline. Study participants were followed in annual or biennial health examinations between 2002 and 2008. The presence of fatty liver was determined at each examination by ultrasound. Cox proportional hazards models were used to evaluate the association of baseline and time-dependent levels of serum uric acid with incident fatty liver, adjusted for potential confounders. During 23 995 person-years of follow-up, 1717 participants developed fatty liver on ultrasound examination. After adjustment for age, body mass index, smoking, and alcohol intake, the hazard ratios (95% confidence intervals) for incident fatty liver comparing quartiles 2 to 4 of serum uric acid to quartile 1 were 1.17 (1.01-1.37), 1.28 (1.11-1.48), and 1.51 (1.31-1.73), respectively (P for trend = .001). The adjusted hazard ratio comparing participants with hyperuricemia (serum uric acid >= 7.0 mg/dL) to those with normouricemia (<7.0 mg/dL) was 1.29 (1.14-1.46). A graded and statistically significant association persisted after adjusting for other cardiometabolic factors and also in time-dependent models. Serum uric acid was an independent risk factor of incident fatty liver detected by ultrasonography. Additional research should clarify the mechanisms underlying this association and the role of hyperuricemia in the development of fatty liver. (C) 2011 Elsevier Inc. All rights reserved.
C1 [Ryu, Seungho; Chang, Yoosoo; Kim, Soo-Geun] Sungkyunkwan Univ, Sch Med, Kangbuk Samsung Hosp, Dept Occupat Med, Seoul 110746, South Korea.
   [Ryu, Seungho; Cho, Juhee; Guallar, Eliseo] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA.
   [Chang, Yoosoo] Sungkyunkwan Univ, Sch Med, Kangbuk Samsung Hosp, Hlth Screening Ctr, Seoul 110746, South Korea.
   [Cho, Juhee] Samsung Med Ctr, Samsung Comprehens Canc Ctr, Seoul 135750, South Korea.
   [Cho, Juhee] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Hlth Behav & Soc, Baltimore, MD USA.
   [Guallar, Eliseo] Johns Hopkins Med Inst, Dept Med, Baltimore, MD 21205 USA.
   [Guallar, Eliseo] Johns Hopkins Med Inst, Welch Ctr Prevent Epidemiol & Clin Res, Baltimore, MD 21205 USA.
   [Guallar, Eliseo] Natl Ctr Cardiovasc Res CNIC, Dept Cardiovasc Epidemiol & Populat Genet, Madrid, Spain.
C3 Sungkyunkwan University (SKKU); Samsung Medical Center; Johns Hopkins
   University; Johns Hopkins Bloomberg School of Public Health;
   Sungkyunkwan University (SKKU); Samsung Medical Center; Sungkyunkwan
   University (SKKU); Samsung Medical Center; Johns Hopkins University;
   Johns Hopkins Bloomberg School of Public Health; Johns Hopkins
   University; Johns Hopkins Medicine; Johns Hopkins University; Johns
   Hopkins Medicine; Centro Nacional de Investigaciones Cardiovasculares
   (CNIC)
RP Guallar, E (corresponding author), Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Welch Ctr Prevent Epidemiol & Clin Res, Baltimore, MD 21205 USA.
EM eguallar@jhsph.edu
RI Cho, Juhee/ABD-2280-2021; Guallar, Eliseo/D-3807-2014
OI Ryu, Seungho/0000-0002-3927-8646; Chang, Yoosoo/0000-0002-6945-9050
FU Kangbuk Samsung Hospital, Seoul, Korea
FX We thank Ms Yiyi Zhang for her collaboration in preparation of Fig. 1.
   The study was supported by Kangbuk Samsung Hospital, Seoul, Korea.
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NR 38
TC 72
Z9 80
U1 0
U2 18
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0026-0495
EI 1532-8600
J9 METABOLISM
JI Metab.-Clin. Exp.
PD JUN
PY 2011
VL 60
IS 6
BP 860
EP 866
DI 10.1016/j.metabol.2010.08.005
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 770GX
UT WOS:000291076100017
PM 20863537
DA 2025-06-11
ER

PT J
AU Hueb, W
   Lopes, N
   Soares, PR
   Gersh, BJ
   Lima, EG
   Vieira, RD
   Garzillo, CL
   Garcia, RR
   Pereira, AC
   Strunz, CM
   Meneguetti, C
   Tsutsui, J
   Parga, J
   Lemos, P
   Hueb, A
   Ushida, A
   Maranhao, R
   Chamone, DA
   Ramires, JAF
AF Hueb, Whady
   Lopes, Neuza
   Soares, Paulo R.
   Gersh, Bernard J.
   Lima, Eduardo Gomes
   Vieira, Ricardo D'Oliveira
   Garzillo, Cibele Larrosa
   Garcia, Rosa Rhami
   Pereira, Alexandre Costa
   Strunz, Celia Maria
   Meneguetti, Claudio
   Tsutsui, Jeane
   Parga, Jose
   Lemos, Pedro
   Hueb, Alexandre
   Ushida, Augusto
   Maranhao, Raul
   Chamone, Dalton A.
   Ramires, Jose A. F.
TI Hypotheses, rationale, design, and methods for prognostic evaluation in
   type 2 diabetic patients with angiographically normal coronary arteries.
   The MASS IV-DM Trial
SO BMC CARDIOVASCULAR DISORDERS
LA English
DT Article
ID EMISSION COMPUTED-TOMOGRAPHY; ENDOTHELIAL DYSFUNCTION;
   MYOCARDIAL-INFARCTION; PRIMARY PREVENTION; CALCIUM SCORE; RISK-FACTORS;
   DISEASE; IMPACT; HEART; ATHEROSCLEROSIS
AB Background: The MASS IV-DM Trial is a large project from a single institution, the Heart Institute (InCor), University of Sao Paulo Medical School, Brazil to study ventricular function and coronary arteries in patients with type 2 diabetes mellitus.
   Methods/Design: The study will enroll 600 patients with type 2 diabetes who have angiographically normal ventricular function and coronary arteries. The goal of the MASS IV-DM Trial is to achieve a long-term evaluation of the development of coronary atherosclerosis by using angiograms and coronary-artery calcium scan by electron-beam computed tomography at baseline and after 5 years of follow-up. In addition, the incidence of major cardiovascular events, the dysfunction of various organs involved in this disease, particularly microalbuminuria and renal function, will be analyzed through clinical evaluation. In addition, an effort will be made to investigate in depth the presence of major cardiovascular risk factors, especially the biochemical profile, metabolic syndrome inflammatory activity, oxidative stress, endothelial function, prothrombotic factors, and profibrinolytic and platelet activity. An evaluation will be made of the polymorphism as a determinant of disease and its possible role in the genesis of micro- and macrovascular damage.
   Discussion: The MASS IV-DM trial is designed to include diabetic patients with clinically suspected myocardial ischemia in whom conventional angiography shows angiographically normal coronary arteries. The result of extensive investigation including angiographic follow-up by several methods, vascular reactivity, pro-thrombotic mechanisms, genetic and biochemical studies may facilitate the understanding of so-called micro- and macrovascular disease of DM.
C1 [Hueb, Whady; Lopes, Neuza; Soares, Paulo R.; Lima, Eduardo Gomes; Vieira, Ricardo D'Oliveira; Garzillo, Cibele Larrosa; Garcia, Rosa Rhami; Pereira, Alexandre Costa; Strunz, Celia Maria; Meneguetti, Claudio; Tsutsui, Jeane; Parga, Jose; Lemos, Pedro; Hueb, Alexandre; Ushida, Augusto; Maranhao, Raul; Chamone, Dalton A.; Ramires, Jose A. F.] Univ Sao Paulo, Inst Heart, Sao Paulo, Brazil.
   [Gersh, Bernard J.] Mayo Clin, Rochester, MN USA.
C3 Universidade de Sao Paulo; Mayo Clinic
RP Hueb, W (corresponding author), Univ Sao Paulo, Inst Heart, Sao Paulo, Brazil.
EM whady.hueb@incor.usp.br
RI Hueb, Whady/A-7919-2013; Parga, Juan/H-4503-2015; Garzillo,
   Cibele/C-6309-2014; Hueb, Alexandre/E-6804-2013; Pereira,
   Claudia/AAZ-9123-2021; Lima, Eduardo/D-4944-2014; Ramires,
   Jose/E-9358-2012; Strunz, Celia/G-5562-2011; Lemos, Pedro/G-5758-2013;
   Maranhao, Raul/I-5996-2012; Ramires, Jose Antonio Franchini/C-5191-2008
OI Strunz, Celia/0000-0002-9766-1184; Hueb, Whady/0000-0002-3166-6054;
   Lemos, Pedro/0000-0002-6782-750X; GARZILLO, CIBELE/0000-0001-8701-8972;
   Maranhao, Raul/0000-0003-1520-4914; Ramires, Jose Antonio
   Franchini/0000-0002-6296-605X
FU Zerbini Foundation; Zerbini Foundation, Sao Paulo, Brazil
FX We would like to thank all members of the MASS IV-DM Trial for their
   hard work in putting together all the forces for performing this study.
   This study was funded partially by the Zerbini Foundation. Medical
   writing support was provided by Ann Conti Morcos during the preparation
   of this paper, supported by the Zerbini Foundation. Responsibility for
   opinions, conclusions, and interpretation of data lies with the
   authors.The MASS IV-DM trial is funded in part by the Zerbini
   Foundation, Sao Paulo, Brazil.
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NR 42
TC 1
Z9 2
U1 0
U2 2
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1471-2261
J9 BMC CARDIOVASC DISOR
JI BMC Cardiovasc. Disord.
PD SEP 29
PY 2010
VL 10
AR 47
DI 10.1186/1471-2261-10-47
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 665YG
UT WOS:000283073400001
PM 20920271
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Dhingra, R
   Gona, P
   Wang, TJ
   Fox, CS
   D'Agostino, RB
   Vasan, RS
AF Dhingra, Ravi
   Gona, Philimon
   Wang, Thomas J.
   Fox, Caroline S.
   D'Agostino, Ralph B., Sr.
   Vasan, Ramachandran S.
TI Serum γ-Glutamyl Transferase and Risk of Heart Failure in the Community
SO ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
LA English
DT Article
DE epidemiology; heart failure; risk factors; oxidative stress;
   gamma-glutamyl transferase
ID CORONARY MICROVASCULAR FUNCTION; CARDIOVASCULAR-DISEASE;
   MYOCARDIAL-INFARCTION; METABOLIC SYNDROME; PROGNOSTIC VALUE;
   TRANSPEPTIDASE; MORTALITY; ASSOCIATION; ALCOHOL; MARKER
AB Objective-To examine the association of serum gamma-glutamyltransferase (GGT) with incident heart failure.
   Methods and Results-We related serum GGT to the incidence of heart failure in 3544 (mean age, 44.5 years; 1833 women and 1711 men) Framingham Study participants who were free of heart failure and myocardial infarction. On follow-up (mean, 23.6 years), 188 participants (77 women) developed new-onset heart failure. In multivariable Cox proportional hazards regression models adjusting for standard risk factors and alcohol consumption as time-varying covariates (updated every 4 years), each SD increase in log-GGT was associated with a 1.39-fold risk of heart failure (95% CI, 1.20 to 1.62). The linearity of the association was confirmed by multivariable-adjusted splines, and the relations remained robust on additional adjustment for hepatic aminotransferases and C-reactive protein. Participants with a serum GGT level at the median or greater had a 1.71-fold risk of heart failure (95% CI, 1.21 to 2.41) compared with individuals with GGT concentrations less than the median. GGT marginally increased the model C-statistic from 0.85 to 0.86 but improved the risk reclassification modestly (net reclassification index, 5.7%; P = 0.01).
   Conclusion-In this prospective study of a large community-based sample, higher serum GGT concentrations within the "normal" range were associated with greater risk of heart failure and incrementally improved prediction of heart failure risk. (Arterioscler Thromb Vasc Biol. 2010;30:1855-1860.)
C1 [Dhingra, Ravi; Wang, Thomas J.; Fox, Caroline S.; D'Agostino, Ralph B., Sr.; Vasan, Ramachandran S.] NHLBI, Framingham Heart Study, Framingham, MA 01702 USA.
   [Dhingra, Ravi] Dartmouth Hitchcock Med Ctr, Div Cardiol, Lebanon, NH 03766 USA.
   [Dhingra, Ravi] Harvard Univ, Sch Publ Hlth, Masters Publ Hlth Program, Boston, MA 02115 USA.
   [Gona, Philimon; D'Agostino, Ralph B., Sr.] Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA USA.
   [Wang, Thomas J.] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Div Cardiol, Boston, MA USA.
   [Fox, Caroline S.] NHLBI, Bethesda, MD 20892 USA.
   [Vasan, Ramachandran S.] Boston Univ, Sch Med, Cardiol Sect, Boston, MA 02118 USA.
   [Vasan, Ramachandran S.] Boston Univ, Sch Med, Dept Prevent Med & Epidemiol, Boston, MA 02118 USA.
C3 National Institutes of Health (NIH) - USA; NIH National Heart Lung &
   Blood Institute (NHLBI); Framingham Heart Study; Dartmouth College;
   Harvard University; Harvard T.H. Chan School of Public Health; Boston
   University; Harvard University; Harvard Medical School; Harvard
   University Medical Affiliates; Massachusetts General Hospital; National
   Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood
   Institute (NHLBI); Boston University; Boston University
RP Vasan, RS (corresponding author), NHLBI, Framingham Heart Study, 73 Mt Wayte Ave,Ste 2, Framingham, MA 01702 USA.
EM vasan@bu.edu
RI Ramachandran, Vasan/Y-2527-2019; Dagostino, Ralph/C-4060-2017; Gona,
   Philimon/K-1477-2019; Wang, Jun/A-7261-2013
OI Ramachandran, Vasan/0000-0001-7357-5970; Wang,
   Thomas/0000-0003-4063-6508
FU National Heart, Lung, and Blood Institute [N01-HC-25195, N01HV28178,
   R01HL71039, R01HL67288]
FX This study was supported by contracts N01-HC-25195, N01HV28178 (Dr
   Vasan), R01HL71039 (Dr Vasan), and R01HL67288 (Dr Vasan) from the
   National Heart, Lung, and Blood Institute's Framingham Heart Study.
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NR 40
TC 67
Z9 72
U1 0
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1079-5642
EI 1524-4636
J9 ARTERIOSCL THROM VAS
JI Arterioscler. Thromb. Vasc. Biol.
PD SEP
PY 2010
VL 30
IS 9
BP 1855
EP 1860
DI 10.1161/ATVBAHA.110.207340
PG 6
WC Hematology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Hematology; Cardiovascular System & Cardiology
GA 641NX
UT WOS:000281135900026
PM 20539015
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Turpin, SM
   Ryall, JG
   Southgate, R
   Darby, I
   Hevener, AL
   Febbraio, MA
   Kemp, BE
   Lynch, GS
   Watt, MJ
AF Turpin, S. M.
   Ryall, J. G.
   Southgate, R.
   Darby, I.
   Hevener, A. L.
   Febbraio, M. A.
   Kemp, B. E.
   Lynch, G. S.
   Watt, M. J.
TI Examination of 'lipotoxicity' in skeletal muscle of high-fat fed and
   ob/ob mice
SO JOURNAL OF PHYSIOLOGY-LONDON
LA English
DT Article
ID INDUCED INSULIN-RESISTANCE; ENDOPLASMIC-RETICULUM STRESS;
   PROTEIN-DEGRADATION; FIBER TYPE; APOPTOSIS; AUTOPHAGY; OBESITY; CELLS;
   EXPRESSION; PATHWAYS
AB Excess lipid accumulation resulting from an elevated supply of plasma fatty acids is linked to the pathogenesis of the metabolic syndrome and heart disease. The term 'lipotoxicity' was coined to describe how lipid accumulation leads to cellular dysfunction and death in non-adipose tissues including the heart, pancreas and liver. While lipotoxicity has been shown in cultured skeletal muscle cells, the degree of lipotoxicity in vivo and the functional consequences are unresolved. We studied three models of fatty acid overload in male mice: 5 h Intralipid((R)) and heparin infusion, prolonged high fat feeding (HFF) and genetic obesity induced by leptin deficiency (ob/ob mice). Markers of apoptosis, proteolysis and autophagy were assessed as readouts of lipotoxicity. The Intralipid((R)) infusion increased caspase 3 activity in skeletal muscle, demonstrating that enhancing fatty acid flux activates pro-apoptotic pathways. HFF and genetic obesity increased tissue lipid content but did not influence apoptosis. Gene array analysis revealed that HFF reduced the expression of 31 pro-apoptotic genes. Markers of autophagy (LC3 beta and beclin-1 expression) were unaffected by HFF and were associated with enhanced Bcl(2) protein expression. Proteolytic activity was similarly unaffected by HFF or in ob/ob mice. Thus, contrary to our previous findings in muscle culture in vitro and in other non-adipose tissues in vivo, lipid overload did not induce apoptosis, autophagy or proteolysis in skeletal muscle. A broad transcriptional suppression of pro-apoptotic proteins may explain this resistance to lipid-induced cell death in skeletal muscle.
C1 [Watt, M. J.] Monash Univ, Dept Physiol, Biol Lipid Metab Lab, Clayton, Vic 3800, Australia.
   [Turpin, S. M.; Kemp, B. E.; Watt, M. J.] Univ Melbourne, St Vincents Inst Med Res, Fitzroy, Vic 3065, Australia.
   [Turpin, S. M.; Kemp, B. E.; Watt, M. J.] Univ Melbourne, Dept Med, Fitzroy, Vic 3065, Australia.
   [Ryall, J. G.; Lynch, G. S.] Univ Melbourne, Dept Physiol, Basic & Clin Myol Lab, Melbourne, Vic 3010, Australia.
   [Southgate, R.] Peter MacCallum Canc Inst, Melbourne 3002, Australia.
   [Darby, I.] RMIT Univ, Sch Med Sci, Bundoora, Vic 3083, Australia.
   [Hevener, A. L.] Diabet & Hypertens Univ Calif, Div Endocrinol, David Geffen Sch Med, Los Angeles, CA 90095 USA.
   [Febbraio, M. A.] Baker IDI Heart & Diabet Inst, Cellular & Mol Metab Lab, Melbourne, Vic 3004, Australia.
C3 Monash University; University of Melbourne; St. Vincent's Institute of
   Medical Research; University of Melbourne; University of Melbourne;
   Peter Maccallum Cancer Center; Royal Melbourne Institute of Technology
   (RMIT); University of California System; University of California Los
   Angeles; University of California Los Angeles Medical Center; David
   Geffen School of Medicine at UCLA; Baker Heart and Diabetes Institute
RP Watt, MJ (corresponding author), Monash Univ, Dept Physiol, Biol Lipid Metab Lab, Clayton, Vic 3800, Australia.
EM matthew.watt@med.monash.edu.au
RI Ryall, James/J-9771-2019; Kemp, Bruce/G-9602-2019; Watt,
   Matthew/B-2089-2014; Febbraio, Mark/AAE-9632-2019; Kemp,
   Bruce/L-2633-2014; Lynch, Gordon/G-9553-2015
OI Turpin-Nolan, Sarah/0000-0002-7469-7934; Kemp,
   Bruce/0000-0001-6735-5082; Febbraio, Mark/0000-0002-9296-4418; Ryall,
   James/0000-0003-4702-1143; Lynch, Gordon/0000-0001-9220-9810; Darby,
   Ian/0000-0002-0990-1986
FU Australian Research Council (ARC); National Health and Medical Research
   Council (NHMRC) of Australia; National Institutes of Health [DK073227]
FX We thank Drs Rudolf Zechner and Gunter Haemmerle (University of Graz)
   for providing the ATGL null mice and Ronnie Minnard for expert technical
   advice. These studies were supported by research grants from the
   Australian Research Council (ARC) and the National Health and Medical
   Research Council (NHMRC) of Australia. S.M.T. is supported by a Dora
   Lush Scholarship, J.G.R. by a C. J. Martin Postdoctoral Fellowship,
   M.A.F. by a Principal Research Fellowship and M.J.W. by a R. Douglas
   Wright Career Development Award from the NHMRC. R.S. is supported by an
   Australian Postdoctoral Fellowship and B.E.K. a Federation Fellowship
   from the ARC. A.L.H. is supported by the National Institutes of Health
   (DK073227).
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NR 52
TC 88
Z9 103
U1 0
U2 13
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-3751
EI 1469-7793
J9 J PHYSIOL-LONDON
JI J. Physiol.-London
PD APR 1
PY 2009
VL 587
IS 7
BP 1593
EP 1605
DI 10.1113/jphysiol.2008.166033
PG 13
WC Neurosciences; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Physiology
GA 427ON
UT WOS:000264788700023
PM 19204053
OA Green Published
DA 2025-06-11
ER

PT J
AU Doyon, C
   Samson, P
   Lalonde, J
   Richard, D
AF Doyon, Christian
   Samson, Pierre
   Lalonde, Josee
   Richard, Denis
TI Effects of the CRF1 receptor antagonist SSR125543 on energy
   balance and food deprivation-induced neuronal activation in obese Zucker
   rats
SO JOURNAL OF ENDOCRINOLOGY
LA English
DT Article
ID CORTICOTROPIN-RELEASING-FACTOR; BROWN-ADIPOSE-TISSUE;
   SYMPATHETIC-NERVOUS-SYSTEM; MESSENGER-RIBONUCLEIC-ACID; HYDROCHLORIDE
   SSR125543A; PARAVENTRICULAR NUCLEUS; INSITU HYBRIDIZATION; ENDOCRINE
   RESPONSES; LEPTIN LEVELS; ADRENAL AXIS
AB The corticotropin-releasing factor (CRF) system is involved in numerous physiological and behavioral actions, including the regulation of energy balance. We examined the effects of the CRF1 receptor antagonist, SSR125543, on energy balance and food deprivation-induced neuronal activation in obese rats. Lean (Fa/?) and obese (fa/fa) Zucker rats were treated orally with SSR125543 at a daily dose of 30 mg/kg for 21 days. Rats were killed either fed ad libitum or food deprived for 6 It in order to induce a mild stress response in obese rats. SSR125543 reduced plasma corticosterone levels in lean rats, prevented corticosterone response to fasting in obese rats, and increased CRF mRNA levels in the paraventricular hypothalamic nucleus (PVN) of both lean and obese rats, further confirming that the antagonist partially blocked CRF1 receptors. SSR125543 increased protein gain in obese rats. Whole carcass analyses showed reduced energy and fat gains in lean rats. Consistent with reduced fat gain, circulating triglyceride and leptin levels were reduced in SSR125543-treated lean rats. In obese rats, circulating glucose levels and the homeostasis model assessment of insulin resistance index of insulin resistance were reduced by SSR125543 treatment. CRF1 receptor blockade increased uncoupling protein-1 mRNA levels in interscapular brown adipose tissue of obese rats. The antagonist partly blocked the fasting-induced changes in c-fos mRNA levels in the PVN and. arcuate nucleus of obese rats. Overall, these results suggest that: although SSR125543 had relatively mild effects on energy balance, CRF1 receptor blockade attenuated several metabolic effects of short-term fasting and improved plasma variables related to the metabolic syndrome and diabetes.
C1 Hop Laval, Chaire Rech Merck Frosst IRSC Obes, Ste Foy, PQ G1V 4G5, Canada.
   Hop Laval, Ctr Rech, Ste Foy, PQ G1V 4G5, Canada.
C3 Laval University; Laval University Hospital; Laval University; Laval
   University Hospital
RP Richard, D (corresponding author), Hop Laval, Chaire Rech Merck Frosst IRSC Obes, 2725 Chemin, Ste Foy, PQ G1V 4G5, Canada.
EM denis.richard@crhl.ulaval.ca
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NR 56
TC 9
Z9 10
U1 0
U2 0
PU BIOSCIENTIFICA LTD
PI BRISTOL
PA STARLING HOUSE, 1600 BRISTOL PARKWAY N, BRISTOL, ENGLAND
SN 0022-0795
EI 1479-6805
J9 J ENDOCRINOL
JI J. Endocrinol.
PD APR
PY 2007
VL 193
IS 1
BP 11
EP 19
DI 10.1677/joe.1.07064
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 159WE
UT WOS:000245897500002
PM 17400798
OA Bronze
DA 2025-06-11
ER

PT J
AU Ozkan, G
   Ceyhan, T
   Catalkaya, G
   Rajan, L
   Ullah, H
   Daglia, M
   Capanoglu, E
AF Ozkan, Gulay
   Ceyhan, Tugce
   Catalkaya, Gizem
   Rajan, Logesh
   Ullah, Hammad
   Daglia, Maria
   Capanoglu, Esra
TI Encapsulated phenolic compounds: clinical efficacy of a novel delivery
   method
SO PHYTOCHEMISTRY REVIEWS
LA English
DT Review
DE Polyphenols; Encapsulation; Bioaccessibility; Stability;
   Bioavailability; Clinical efficacy
ID IN-VITRO; CHEMOTHERAPEUTIC EFFICACY; DIETARY PHYTOESTROGEN; ORAL
   BIOAVAILABILITY; ANTICANCER EFFICACY; OXIDATIVE STRESS; GENE-EXPRESSION;
   HEALTHY HUMANS; GALLIC ACID; NARINGENIN
AB Encapsulation is a drug or food ingredient loaded-delivery system that entraps active components, protecting them from decomposition/degradation throughout the processing and storage stages and facilitates their delivery to the target tissue/organ, improving their bioactivities. The application of this technology is expanding gradually from pharmaceuticals to the food industry, since dietary bioactive ingredients, including polyphenols, are susceptible to environmental and/or gastrointestinal conditions. Polyphenols are the largest group of plants' secondary metabolites, with a wide range of biological effects. Literature data have indicated their potential in the prevention of several disorders and pathologies, ranging from simpler allergic conditions to more complex metabolic syndrome and cardiovascular and neurodegenerative diseases. Despite the promising health effects in preclinical studies, the clinical use of dietary polyphenols is still very limited due to their low bioaccessibility and/or bioavailability. Encapsulation can be successfully employed in the development of polyphenol-based functional foods, which may improve their bioaccessibility and/or bioavailability. Moreover, encapsulation can also aid in the targeted delivery of polyphenols and may prevent any possible adverse events. For the encapsulation of bioactive ingredients, several techniques are applied such as emulsion phase separation, emulsification/internal gelation, film formation, spray drying, spray-bed-drying, fluid-bed coating, spray-chilling, spray-cooling, and melt injection. The present review aims to throw light on the existing literature highlighting the possibility and clinical benefits of encapsulated polyphenols in health and disease. However, the clinical data is still very scarce and randomized clinical trials are needed before any conclusion is drawn.
C1 [Ozkan, Gulay; Ceyhan, Tugce; Catalkaya, Gizem; Capanoglu, Esra] Istanbul Tech Univ, Fac Chem & Met Engn, Dept Food Engn, 34469 Maslak, TR-80626 Istanbul, Turkiye.
   [Ceyhan, Tugce] Istanbul Aydin Univ, Fac Engn, Dept Food Engn, TR-34295 Istanbul, Turkiye.
   [Rajan, Logesh] JSS Acad Higher Educ & Res, JSS Coll Pharm, Dept Pharmacognosy, Mysuru 570015, Karnataka, India.
   [Ullah, Hammad; Daglia, Maria] Univ Naples Federico II, Dept Pharm, I-80131 Naples, Italy.
   [Daglia, Maria] Jiangsu Univ, Int Res Ctr Food Nutr & Safety, Zhenjiang 212013, Peoples R China.
C3 Istanbul Technical University; Istanbul Aydin University; JSS Academy of
   Higher Education & Research; JSS College of Pharmacy, Mysuru; University
   of Naples Federico II; Jiangsu University
RP Capanoglu, E (corresponding author), Istanbul Tech Univ, Fac Chem & Met Engn, Dept Food Engn, 34469 Maslak, TR-80626 Istanbul, Turkiye.
EM capanogl@itu.edu.tr
RI Daglia, Maria/AAC-9498-2019; Rajan, Logesh/HPH-7500-2023; Capanoglu,
   Esra/A-4455-2018; Ozkan, Gulay/LLM-3399-2024; Catalkaya,
   Gizem/O-9719-2019; Ullah, Hammad/AAF-1802-2019
OI CEYHAN, Tugce/0000-0002-7189-7439; Capanoglu, Esra/0000-0003-0335-9433
FU Istanbul Technical University
FX No Statement Available
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PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
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JI Phytochem. Rev.
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ER

PT J
AU Neumiller, JJ
   Alicic, RZ
   Tuttle, KR
AF Neumiller, Joshua J.
   Alicic, Radica Z.
   Tuttle, Katherine R.
TI Optimization of guideline-directed medical therapies in patients with
   diabetes and chronic kidney disease
SO CLINICAL KIDNEY JOURNAL
LA English
DT Review
DE finerenone; GLP-1 receptor agonists; pathomechanisms; risk mitigation;
   SGLT2 inhibitors
ID PEPTIDE-1 RECEPTOR AGONISTS; COTRANSPORTER 2 INHIBITION; CARDIOVASCULAR
   OUTCOMES; THERAPEUTIC TARGETS; RENAL INFLAMMATION; SGLT2 INHIBITORS;
   OXIDATIVE STRESS; GLP-1 AGONISTS; DOUBLE-BLIND; EFFICACY
AB Diabetes is the leading cause of chronic kidney disease (CKD) and kidney failure worldwide. CKD frequently coexists with heart failure and atherosclerotic cardiovascular disease in the broader context of cardio-kidney-metabolic syndrome. Diabetes and CKD are associated with increased risk of all-cause and cardiovascular death as well as decreased quality of life. The role of metabolic and hemodynamic abnormalities has long been recognized as an important contributor to the pathogenesis and progression of CKD in diabetes, while a more recent and growing body of evidence supports activation of both systemic and local inflammation as important contributors. Current guidelines recommend therapies targeting pathomechanisms of CKD in addition to management of traditional risk factors such as hyperglycemia and hypertension. Sodium-glucose cotransporter-2 inhibitors are recommended for treatment of patients with CKD and type 2 diabetes (T2D) if eGFR is >= 20 ml/min/173 m2 on a background of renin-angiotensin system inhibition. For patients with T2D, CKD, and atherosclerotic cardiovascular disease, a glucagon-like peptide-1 receptor agonist is recommended as additional risk-based therapy. A non-steroidal mineralocorticoid receptor antagonist is also recommended as additional risk-based therapy for persistent albuminuria in patients with T2D already treated with renin-angiotensin system inhibition. Implementation of guideline-directed medical therapies is challenging in the face of rapidly accumulating knowledge, high cost of medications, and lack of infrastructure for optimal healthcare delivery. Furthermore, studies of new therapies have focused on T2D and CKD. Clinical trials are now planned to inform the role of these therapies in people with type 1 diabetes (T1D) and CKD.
C1 [Neumiller, Joshua J.] Washington State Univ, Coll Pharm & Pharmaceut Sci, Spokane, WA 99202 USA.
   [Neumiller, Joshua J.; Alicic, Radica Z.; Tuttle, Katherine R.] Providence Inland Northwest Hlth, Providence Med Res Ctr, Spokane, WA 99204 USA.
   [Alicic, Radica Z.; Tuttle, Katherine R.] Univ Washington, Dept Med, Seattle, WA USA.
   [Tuttle, Katherine R.] Univ Washington, Kidney Res Inst, Nephrol Div, Seattle, WA USA.
   [Tuttle, Katherine R.] Univ Washington, Inst Translat Hlth Sci, Seattle, WA USA.
C3 Washington State University; University of Washington; University of
   Washington Seattle; University of Washington; University of Washington
   Seattle; University of Washington; University of Washington Seattle
RP Neumiller, JJ (corresponding author), Washington State Univ, Coll Pharm & Pharmaceut Sci, Spokane, WA 99202 USA.; Neumiller, JJ (corresponding author), Providence Inland Northwest Hlth, Providence Med Res Ctr, Spokane, WA 99204 USA.
EM jneumiller@wsu.edu
OI Tuttle, Katherine/0000-0002-2235-0103
CR Administration USDoHaHSFaD, 2008, GUID IND DIAB MELL E
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NR 147
TC 4
Z9 5
U1 0
U2 4
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 2048-8505
EI 2048-8513
J9 CLIN KIDNEY J
JI Clin. Kidney J.
PD JAN 4
PY 2024
VL 17
IS 1
DI 10.1093/ckj/sfad285
EA DEC 2023
PG 16
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA ET3P5
UT WOS:001128492300001
PM 38213492
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Elseweidy, MM
   Ali, A
   Hassanin, SM
   Mahmoud, YK
AF Elseweidy, Mohamed M.
   Ali, Abd El-Monem
   Hassanin, Sara M.
   Mahmoud, Yasmin K.
TI Empagliflozin ameliorates liver fibrosis in NASH rat model via targeting
   hepatic NF-κB/SOX9/OPN signaling and osteocalcin level
SO NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
LA English
DT Article
DE Empagliflozin; Non-alcoholic steatohepatitis; Liver fibrosis; SOX9; OPN;
   Osteocalcin
ID KAPPA-B; INSULIN-RESISTANCE; METABOLIC SYNDROME; SERUM OSTEOCALCIN;
   OXIDATIVE STRESS; STELLATE CELLS; ACTIVATION; DISEASE; PROLIFERATION;
   ASSOCIATION
AB Non-alcoholic steatohepatitis (NASH) may be associated with tissue fibrotic changes and can be treated via different therapeutic tools which may however either initiate weak or long-term side effects that minimize its use. Empagliflozin (EMPA) is an oral anti-diabetic drug which has characteristic effects during hepatic steatosis regarding lipid accumulation and insulin resistance. In this study, we aimed to investigate an additional mechanism through which EMPA can exert and potentiate its anti-inflammatory and anti-fibrotic effects in NASH rat model. Male Wistar albino rats fed on high fat diet (HFD) and 20% fructose in drinking water for 18 weeks and received EMPA (30 mg/kg/day, orally) starting from week 11. Body and liver weights, homeostatic model assessment of insulin resistance (HOMA-IR), lipid profile, liver function tests, other biochemical and histological parameters were determined. HFD joined with fructose intake significantly increased body and liver weights, HOMA-IR value, hepatic inflammatory and fibrotic markers, liver transaminases, hepatic expression of nuclear factor-kappa B (NF-kappa B), sex determining region Y box 9 (SOX 9), and osteopontin (OPN) with significant decrease in hepatic osteocalcin (OCN). Intense hepatic lesions with severe microsteatosis and deposition of collagen fibers were clearly observed. Effectively, EMPA restored the normal liver functions, downregulated hepatic inflammatory cytokines, NF-kappa B, SOX 9, OPN, and increased OCN level. These results highlight another pathway illustrated the anti-fibrotic effects of EMPA against liver fibrosis probably through downregulation of NF-kappa B/SOX 9/OPN signaling along with upregulation of hepatic OCN which may potentiate the valuable anti-inflammatory and anti-fibrotic effects of EMPA.
C1 [Elseweidy, Mohamed M.; Mahmoud, Yasmin K.] Zagazig Univ, Fac Pharm, Biochem Dept, Zagazig 44519, Egypt.
   [Ali, Abd El-Monem] Zagazig Univ, Fac Vet Med, Pathol Dept, Zagazig 44519, Egypt.
   [Hassanin, Sara M.] Zagazig Univ, Zagazig Univ Hosp, Zagazig, Egypt.
C3 Egyptian Knowledge Bank (EKB); Zagazig University; Egyptian Knowledge
   Bank (EKB); Zagazig University; Egyptian Knowledge Bank (EKB); Zagazig
   University
RP Mahmoud, YK (corresponding author), Zagazig Univ, Fac Pharm, Biochem Dept, Zagazig 44519, Egypt.
EM ykhelmy@zu.edu.eg
FU All the authors acknowledge the support provided by the Faculty of
   Pharmacy, Zagazig University for using the animal care unit and research
   laboratories in performing this experiment.; Faculty of Pharmacy,
   Zagazig University
FX All the authors acknowledge the support provided by the Faculty of
   Pharmacy, Zagazig University for using the animal care unit and research
   laboratories in performing this experiment.
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BP 3449
EP 3459
DI 10.1007/s00210-023-02826-6
EA NOV 2023
PG 11
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA PO3O2
UT WOS:001104276300003
PM 37962587
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Triggle, CR
   Marei, I
   Ye, KV
   Ding, H
   Anderson, TJ
   Hollenberg, MD
   Hill, MA
AF Triggle, Chris R. R.
   Marei, Isra
   Ye, Kevin
   Ding, Hong
   Anderson, Todd J. J.
   Hollenberg, Morley D. D.
   Hill, Michael A. A.
TI Repurposing Metformin for Vascular Disease
SO CURRENT MEDICINAL CHEMISTRY
LA English
DT Review
DE Metformin; vascular disease; type 2 diabetes; endothelium; inflammation;
   obesity; SARS-CoV-2; COVID-19
ID ENDOTHELIAL PROGENITOR CELLS; CHRONIC KIDNEY-DISEASE; ACTIVATED
   PROTEIN-KINASE; TYPE-2 DIABETES-MELLITUS; BLOOD-GLUCOSE CONTROL;
   OXIDATIVE STRESS; LIFE-SPAN; CARDIOVASCULAR-DISEASE; INSULIN
   SENSITIVITY; HEART-FAILURE
AB Metformin has been used as an oral anti-hyperglycaemic drug since the late 1950s; however, following the release in 1998 of the findings of the 20-year United Kingdom Prospective Diabetes Study (UKPDS), metformin use rapidly increased and today is the first-choice anti-hyperglycaemic drug for patients with type 2 diabetes (T2D). Metformin is in daily use by an estimated 150 million people worldwide. Historically, the benefits of metformin as an anti-diabetic and cardiovascular-protective drug have been linked to effects in the liver, where it acts to inhibit gluconeogenesis and lipogenesis, as well as reduce insulin resistance and enhance peripheral glucose utilization. However, direct protective effects on the endothelium and effects in the gut prior to metformin absorption are now recognized as important. In the gut, metformin modulates the glucagon-like peptide-1 (GLP-1) - gut-brain axis and impacts the intestinal microbiota. As the apparent number of putative tissue and cellular targets for metformin has increased, so has the interest in re-purposing metformin to treat other diseases that include polycystic ovary syndrome (PCOS), cancer, neurodegenerative diseases, and COVID-19. Metformin is also being investigated as an anti-ageing drug. Of particular interest is whether metformin provides the same level of vascular protection in individuals other than those with T2D, including obese individuals with metabolic syndrome, or in the setting of vascular thromboinflammation caused by SARS-CoV-2. In this review, we critically evaluate the literature to highlight clinical settings in which metformin might be therapeutically repurposed for the prevention and treatment of vascular disease.
C1 [Triggle, Chris R. R.; Marei, Isra; Ding, Hong] Weill Cornell Med Qatar, Dept Pharmacol & Med Educ, POB 24144, Doha, Qatar.
   [Ye, Kevin] Simon Fraser Univ, Dept Biomed Physiol & Kinesiol, Burnaby, BC V5A 1S6, Canada.
   [Anderson, Todd J. J.] Univ Calgary, Cumming Sch Med, Dept Cardiac Sci, Calgary, AB T2N 4N1, Canada.
   [Anderson, Todd J. J.] Univ Calgary, Libin Cardiovasc Inst, Cumming Sch Med, Calgary, AB T2N 4N1, Canada.
   [Hollenberg, Morley D. D.] Univ Calgary, Cumming Sch Med, Dept Physiol & Pharmacol, Calgary, AB T2N 4N1, Canada.
   [Hollenberg, Morley D. D.] Univ Calgary, Cumming Sch Med, Dept Med, Calgary, AB T2N 4N1, Canada.
   [Hill, Michael A. A.] Univ Missouri, Dalton Cardiovasc Res Ctr, Sch Med, Columbia, MO 65211 USA.
   [Hill, Michael A. A.] Univ Missouri, Sch Med, Dept Med Pharmacol & Physiol, Columbia, MO 65211 USA.
C3 Qatar Foundation (QF); Weill Cornell Medical College Qatar; Simon Fraser
   University; University of Calgary; Libin Cardiovascular Institute Of
   Alberta; University of Calgary; University of Calgary; University of
   Calgary; University of Missouri System; University of Missouri Columbia;
   University of Missouri System; University of Missouri Columbia
RP Triggle, CR (corresponding author), Weill Cornell Med Qatar, Dept Pharmacol & Med Educ, POB 24144, Doha, Qatar.
EM cht2011@qatar-med.cornell.edu
RI marei, Isra/GPW-6811-2022
OI Ye, Kevin/0000-0002-5015-4089; Anderson, Todd/0000-0003-3751-6468; Ding,
   Hong/0000-0003-2164-1870; Triggle, Christopher/0000-0001-5307-0537
FU ECRA award Qatar National Research Fund; L'Oreal-UNESCO For Women in
   Science Young Talents Program/Middle East, 2020
FX Dr. Isra Marei was supported by an ECRA award from the Qatar National
   Research Fund (a member of Qatar Foundation) and the L'Oreal-UNESCO For
   Women in Science Young Talents Program/Middle East, 2020. Figs 1, 2 and
   3 were created using BioRender.com under the academic licenses: Fig 1
   YJ23IOMTFM, Fig 2 LWDE65Q5, and Fig 3 PD23KOMNTT.
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NR 162
TC 14
Z9 14
U1 3
U2 9
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 0929-8673
EI 1875-533X
J9 CURR MED CHEM
JI Curr. Med. Chem.
PY 2023
VL 30
IS 35
BP 3955
EP 3978
DI 10.2174/0929867329666220729154615
PG 24
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Pharmacology &
   Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
GA L6AY9
UT WOS:001024084000003
PM 35909294
OA Green Published
DA 2025-06-11
ER

PT J
AU Dong, J
   Hu, LK
   Lu, YK
   Liu, YH
   Chu, X
   Yan, YX
AF Dong, Jing
   Hu, Li-Kun
   Lu, Ya-Ke
   Liu, Yu-Hong
   Chu, Xi
   Yan, Yu-Xiang
TI Association of serum uric acid with the risk of developing hypertension:
   A prospective cohort study with mediation analysis
SO HYPERTENSION RESEARCH
LA English
DT Article
DE Serum uric acid; Hypertension; Mediation analysis
ID NUTRITION EXAMINATION SURVEY; ELEVATED BLOOD-PRESSURE; METABOLIC
   SYNDROME; NATIONAL-HEALTH; DEPRESSIVE SYMPTOMS; OXIDATIVE STRESS; LEVEL;
   POPULATION; ADOLESCENTS; OBESITY
AB Elevated serum uric acid (SUA) is associated with the incidence of hypertension, but whether relevant metabolic factors have mediating effects is not certain. Our study was based on a functional community cohort established in Beijing. In 2015, a total of 7482 individuals without hypertension were recruited and followed up until 2019. Multivariate logistic regression analysis was used to investigate the association between SUA and hypertension. Cross-lagged panel analysis and mediation analysis were used to explore the effects of metabolic factors on the association between SUA and incident hypertension. During the average 4-year follow-up, the cumulative incidence of hypertension was 10.9% (n = 580). SUA was an independent risk factor for hypertension, and the RRs (95% CI) for subjects with baseline SUA levels in quartile 2, quartile 3 and quartile 4 were 1.20 (0.88-1.63), 1.50 (1.10-2.05), and 1.57 (1.11-2.22) compared to those in quartile 1, respectively. The cross-lagged panel analysis showed that the increases in Cr, TG, LDL, ALT, AST and WBC occurred after SUA increased (P < 0.001). Among these factors, TG, WBC and ALT played an intermediary role in both men (TG: 14.76%; WBC: 11.61%; ALT: 15.93%) and women (TG: 14.55%; WBC: 8.55%; ALT: 6.89%). The elevated SUA concentration was an independent risk factor for hypertension in the Chinese population, and TG, WBC and ALT had important mediating effects on the association between SUA and hypertension.
C1 [Dong, Jing; Chu, Xi] Capital Med Univ, Xuanwu Hosp, Hlth Management Ctr, Beijing, Peoples R China.
   [Hu, Li-Kun; Lu, Ya-Ke; Liu, Yu-Hong; Yan, Yu-Xiang] Capital Med Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing, Peoples R China.
   [Yan, Yu-Xiang] Municipal Key Lab Clin Epidemiol, Beijing, Peoples R China.
C3 Capital Medical University; Capital Medical University
RP Chu, X (corresponding author), Capital Med Univ, Xuanwu Hosp, Hlth Management Ctr, Beijing, Peoples R China.; Yan, YX (corresponding author), Capital Med Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing, Peoples R China.; Yan, YX (corresponding author), Municipal Key Lab Clin Epidemiol, Beijing, Peoples R China.
EM cissy9007@163.com; yanyxepi@ccmu.edu.cn
RI Dong, Jing/KDM-6171-2024
OI Lu, Ya-Ke/0000-0002-5845-7033
FU National Natural Science Foundation of China [81773511, 81573214]
FX This work was supported by grants from the National Natural Science
   Foundation of China (81773511, 81573214).
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NR 64
TC 7
Z9 9
U1 4
U2 18
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0916-9636
EI 1348-4214
J9 HYPERTENS RES
JI Hypertens. Res.
PD FEB
PY 2023
VL 46
IS 2
BP 345
EP 356
DI 10.1038/s41440-022-01081-1
EA NOV 2022
PG 12
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 8P5SJ
UT WOS:000881689700002
PM 36357616
DA 2025-06-11
ER

PT J
AU Nesti, L
   Pugliese, NR
   Chiriacò, M
   Trico, D
   Baldi, S
   Natali, A
AF Nesti, Lorenzo
   Pugliese, Nicola Riccardo
   Chiriaco, Martina
   Trico, Domenico
   Baldi, Simona
   Natali, Andrea
TI Epicardial adipose tissue thickness is associated with reduced peak
   oxygen consumption and systolic reserve in patients with type 2 diabetes
   and normal heart function
SO DIABETES OBESITY & METABOLISM
LA English
DT Article
DE cardiopulmonary exercise test; cardiopulmonary fitness; diabetic
   cardiomyopathy; echocardiography; effort intolerance; epicardial adipose
   tissue; heart failure with preserved ejection fraction; type 2 diabetes
ID LEFT-VENTRICULAR DYSFUNCTION; EUROPEAN ASSOCIATION; METABOLIC SYNDROME;
   FAT; ECHOCARDIOGRAPHY; FAILURE; MELLITUS; IMPACT
AB Aim To investigate the impact of epicardial adipose tissue (EAT) thickness on cardiopulmonary performance in patients with type 2 diabetes (T2D) and normal heart function. Materials and methods We analysed EAT thickness in subjects with T2D and normal biventricular systo-diastolic functions undergoing a maximal cardiopulmonary exercise test combined with stress echocardiography, speckle tracking and pulmonary function assessment, as well as serum N-terminal pro B-type natriuretic peptide (NT-proBNP). Results In the 72 subjects enrolled, those with EAT thickness above the median (> 5 mm) showed higher body fat mass, smaller indexed left ventricular dimensions and marginally reduced diastolic function variables at rest. Higher EAT thickness was associated with lower peak oxygen uptake (VO2peak 17.1 +/- 3.6 vs. 21.0 +/- 5.7 ml/min/kg, P = .001), reduced systolic reserve (Delta S ' 4.6 +/- 1.6 vs. 5.8 +/- 2.5 m/s, P = .02) and higher natriuretic peptides (NT-proBNP 64 [29-165] vs. 31 [26-139] pg/ml, P = .04), as well as chronotropic insufficiency and impaired heart rate recovery. Ventilatory variables and peripheral oxygen extraction were not different between groups. EAT was independently associated with VO2peak and linearly and negatively correlated with peak heart rate, heart rate recovery, workload, VO2 at the anaerobic threshold and at peak, and cardiac power output, and was directly correlated with natriuretic peptides. Conclusion Higher EAT thickness in T2D is associated with worse cardiopulmonary performance and multiple traits of subclinical cardiac systolic dysfunction.
C1 [Nesti, Lorenzo; Chiriaco, Martina; Trico, Domenico; Baldi, Simona; Natali, Andrea] Univ Pisa, Dept Clin & Expt Med, Metab Nutr & Atherosclerosis Lab, Pisa, Italy.
   [Nesti, Lorenzo; Pugliese, Nicola Riccardo; Chiriaco, Martina; Natali, Andrea] Univ Pisa, Dept Clin & Expt Med, Cardiopulm Lab, Pisa, Italy.
C3 University of Pisa; University of Pisa
RP Nesti, L (corresponding author), Univ Pisa, Dipartimento Med Clin & Sperimentale, Via Savi 27, I-56100 Pisa, Italy.
EM lorenzo.nesli@phd.unipi.it
RI Natali, Andrea/N-5535-2015; Pugliese, Nicola/J-9295-2019; Chiriaco,
   Martina/AAY-2611-2021; Nesti, Lorenzo/AAB-7426-2022; Trico,
   Domenico/A-9002-2017
OI Chiriaco, Martina/0000-0003-0174-4549; Nesti,
   Lorenzo/0000-0002-0560-6496; Trico, Domenico/0000-0002-7633-1346
FU Universita degli Studi di Pisa within the CRUI-CARE Agreement
FX Open Access Funding provided by Universita degli Studi di Pisa within
   the CRUI-CARE Agreement.
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NR 50
TC 28
Z9 28
U1 1
U2 12
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1462-8902
EI 1463-1326
J9 DIABETES OBES METAB
JI Diabetes Obes. Metab.
PD JAN
PY 2023
VL 25
IS 1
BP 177
EP 188
DI 10.1111/dom.14861
EA SEP 2022
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 9J9WL
UT WOS:000860339500001
PM 36066008
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Sabbieti, MG
   Marchegiani, A
   Sufianov, AA
   Gabai, VL
   Shneider, A
   Agas, D
AF Sabbieti, Maria Giovanna
   Marchegiani, Andrea
   Sufianov, Albert A.
   Gabai, Vladimir L.
   Shneider, Alexander
   Agas, Dimitrios
TI P62/SQSTM1 beyond Autophagy: Physiological Role and Therapeutic
   Applications in Laboratory and Domestic Animals
SO LIFE-BASEL
LA English
DT Review
DE p62; SQSTM1; inflammation; aging; inflammatory diseases; degenerative
   diseases
ID CANINE MAMMARY-TUMORS; POOR-PROGNOSIS; DNA VACCINE; PROTEIN P62;
   DISEASE; DOGS; OSTEOARTHRITIS; DEGENERATION; INFLAMMATION; MUTATION
AB Inflammation is the preceding condition for the development of mild and severe pathological conditions, including various forms of osteopenia, cancer, metabolic syndromes, neurological disorders, atherosclerosis, cardiovascular, lung diseases, etc., in human and animals. The inflammatory status is induced by multifarious intracellular signaling cascades, where cytokines, chemokines, arachidonic acid metabolites, adhesion molecules, immune cells and other components foster a "slow burn" at a local or systemic level. Assuming that countering inflammation limits the development of inflammation-based diseases, a series of new side-effects-free therapies was assessed in experimental and domestic animals. Within the targets of the drug candidates for quenching inflammation, an archetypal autophagic gear, the p62/sqstm1 protein, has currently earned attention from researchers. Intracellular p62 has been recently coined as a multi-task tool associated with autophagy, bone remodeling, bone marrow integrity, cancer progression, and the maintenance of systemic homeostasis. Accordingly, p62 can act as an effective suppressor of inflamm-aging, reducing oxidative stress and proinflammatory signals. Such an operational schedule renders this protein an effective watchdog for degenerative diseases and cancer development in laboratory and pet animals. This review summarizes the current findings concerning p62 activities as a molecular hub for cell and tissues metabolism and in a variety of inflammatory diseases and other pathological conditions. It also specifically addresses the applications of exogenous p62 (DNA plasmid) as an anti-inflammatory and homeostatic regulator in the treatment of osteoporosis, metabolic syndrome, age-related macular degeneration and cancer in animals, and the possible application of p62 plasmid in other inflammation-associated diseases.
C1 [Sabbieti, Maria Giovanna; Marchegiani, Andrea; Agas, Dimitrios] Univ Camerino, Sch Biosci & Vet Med, I-62032 Camerino, Italy.
   [Sufianov, Albert A.] Fed Ctr Neurosurg, Tyumen 625032, Russia.
   [Sufianov, Albert A.] Sechenov First Moscow State Med Univ, Moscow 119991, Russia.
   [Gabai, Vladimir L.; Shneider, Alexander] CureLab Oncol Inc, Dedham, MA 02026 USA.
   [Shneider, Alexander] Ariel Univ, Dept Mol Biol, IL-40700 Ariel, Israel.
   [Shneider, Alexander] Peter Great St Petersburg Polytech Univ, Inst Biomed Syst & Biotechnol, St Petersburg 195251, Russia.
C3 University of Camerino; Sechenov First Moscow State Medical University;
   Ariel University; Peter the Great St. Petersburg Polytechnic University
RP Agas, D (corresponding author), Univ Camerino, Sch Biosci & Vet Med, I-62032 Camerino, Italy.
EM giovanna.sabbieti@unicam.it; andrea.marchegiani@unicam.it;
   sufianov@gmail.com; vgabai@curelab.com; ashneider@curelab.com;
   dimitrios.agas@unicam.it
RI Agas, Dimitrios/AAO-9214-2021; Marchegiani, Andrea/L-3533-2019;
   Sufianov, Albert/C-4799-2017; Gabai, Vladimir/I-1650-2013
OI Agas, Dimitrios/0000-0002-7809-3601; Marchegiani,
   Andrea/0000-0002-3629-0391; Sabbieti, Maria Giovanna/0000-0002-0838-5748
FU UNICAM Noemi Avicolli funds
FX This work was financially supported by the UNICAM Noemi Avicolli funds.
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NR 81
TC 10
Z9 11
U1 0
U2 9
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2075-1729
J9 LIFE-BASEL
JI Life-Basel
PD APR
PY 2022
VL 12
IS 4
AR 539
DI 10.3390/life12040539
PG 12
WC Biology; Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics; Microbiology
GA 0S1NR
UT WOS:000786048900001
PM 35455030
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU De León-Ramírez, YM
   Lara-García, M
   Pacheco, P
   Lara-García, O
   Martínez-Gómez, M
   Cuevas-Romero, E
   Rodríguez-Antolín, J
   Nicolás-Toledo, L
AF De Leon-Ramirez, Yeimy Mar
   Lara-Garcia, Miguel
   Pacheco, Pablo
   Lara-Garcia, Omar
   Martinez-Gomez, Margarita
   Cuevas-Romero, Estela
   Rodriguez-Antolin, Jorge
   Nicolas-Toledo, Leticia
TI Histomorphological testicular changes and decrease in the sperm count in
   pubertal rats induced by a high-sugar diet
SO ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER
LA English
DT Article
DE Lactate dehydrogenase expression; Leptin; Pubertal; Rats; Sperm quality;
   Testosterone; Triacylglycerol
ID HIGH-SUCROSE DIET; LEPTIN RECEPTOR; CHRONIC STRESS; TESTOSTERONE
   PRODUCTION; ENERGY-METABOLISM; FATTY-ACIDS; LACTATE; TESTIS; EXPRESSION;
   OBESITY
AB Background: During childhood and adolescence, excessive food consumption stimulates adipose tissue expansion promoting overweight in humans, and mice. A high-sucrose diet is related to obesity and metabolic syndrome. Infertility is commonly related to these pathologies. We aim to evaluate possible histomorphological testicular changes induced by a high-sucrose diet on sperm count during the post-weaning period.
   Methods: Wistar male rats aged 21 days, weaned, were randomly assigned into two groups: control (fed and hydrated normally) and sugar group (fed normally but hydrated with a solution containing 30% of diluted sucrose during 30 days). At the pubertal age of 51 days, animals were killed and blood samples were taken to measure testosterone and leptin. Testicles were collected and gonadal adipose tissue and semen samples from the epididymis were excised. Testicle samples were used for morphological description using H&E staining, as well as to quantify the triacylglycerol content and the lactate dehydrogenase (LDH) expression. Semen samples were used to assess motility, viability, and sperm count.
   Results: The sugar group presented an increase in the testicular weight, but a reduction in the cross-sectional area of seminiferous tubules. Moreover, disorganization of Sertoli cells and spermatogonia, an increase in the LDH expression within the entire seminiferous tubule, and a reduced sperm count and spermatozoid motility were found. These alterations were accompanied by high serum levels of testosterone and leptin.
   Conclusions: Our results indicate strong damage of testis by sugar consumption during early life that may lead to the onset of infertility in adulthood. (C) 2021 Elsevier GmbH. All rights reserved.
C1 [De Leon-Ramirez, Yeimy Mar] Univ Autonoma Tlaxcala, Ciencias Biol, Santa Maria Acuitlapilco, Mexico.
   [Lara-Garcia, Miguel; Pacheco, Pablo; Martinez-Gomez, Margarita] Univ Veracruzana, Inst Neuroetol, Veracruz, Mexico.
   [Pacheco, Pablo; Martinez-Gomez, Margarita] Univ Nacl Autonoma Mexico, Inst Invest Biomed, Dept Biol Celular & Fisiol, Mexico City, DF, Mexico.
   [Lara-Garcia, Omar; Cuevas-Romero, Estela; Rodriguez-Antolin, Jorge; Nicolas-Toledo, Leticia] Univ Autonoma Tlaxcala, Ctr Tlaxcala Biol Conducta, Tlaxcala 90000, Mexico.
C3 Universidad Veracruzana; Universidad Nacional Autonoma de Mexico
RP Nicolás-Toledo, L (corresponding author), Univ Autonoma Tlaxcala, Ctr Tlaxcala Biol Conducta, Tlaxcala 90000, Mexico.
EM leticia.nicolast@uatx.mx
RI Estela, Cuevas-Romero/H-7856-2019; Martinez, Margarita/KFR-3842-2024;
   Nicolás-Toledo, Leticia/AAA-4587-2022; García, Miguel/X-9535-2019;
   Rodríguez-Antolín, Jorge/HZH-9026-2023; Lara Garcia, Miguel/N-3170-2016;
   Pacheco, Pablo/I-6762-2016
OI Cuevas-Romero, Estela/0000-0003-3960-2351; Rodriguez-Antolin,
   Jorge/0000-0003-3971-437X; Lara-Garcia, Omar/0000-0002-0141-8180; Lara
   Garcia, Miguel/0000-0002-8460-1326; De Leon-Ramirez, Yeimy
   Mar/0000-0001-8887-8317; Pacheco, Pablo/0000-0001-5692-2627
FU Consejo Nacional de Ciencia y Tecnologia (CONACyT) [287762, 631998];
   SEP-PRODEP through the Cuerpo Academico Consolidado Metabolismo y
   Reproduccion Clave [UATLx-CA-237]
FX Authors thank the Consejo Nacional de Ciencia y Tecnologia (CONACyT)for
   supporting this research project (Grant no. 287762 to L. Nicolas-Toledo,
   Proyecto apoyado por el Fondo Sectorial de Investigacion para la
   Educacion) and for providing research fellowships to YM. De Leon-Ramirez
   (Reg. 631998). We also thank to SEP-PRODEP that through the Cuerpo
   Academico Consolidado Metabolismo y Reproduccion Clave UATLx-CA-237 gave
   the postdoctoral fellowship to O, Lara-Garcia.
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NR 48
TC 11
Z9 12
U1 1
U2 23
PU ELSEVIER GMBH
PI MUNICH
PA HACKERBRUCKE 6, 80335 MUNICH, GERMANY
SN 0940-9602
EI 1618-0402
J9 ANN ANAT
JI Ann. Anat.-Anat. Anz.
PD MAY
PY 2021
VL 235
AR 151678
DI 10.1016/j.aanat.2021.151678
EA FEB 2021
PG 8
WC Anatomy & Morphology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Anatomy & Morphology
GA RG6WU
UT WOS:000635677000010
PM 33515690
DA 2025-06-11
ER

PT J
AU Nishigori, T
   Obama, K
   Sakai, Y
AF Nishigori, Tatsuto
   Obama, Kazutaka
   Sakai, Yoshiharu
TI Assessment of body composition and impact of sarcopenia and sarcopenic
   obesity in patients with gastric cancer
SO TRANSLATIONAL GASTROENTEROLOGY AND HEPATOLOGY
LA English
DT Review
DE Body composition; sarcopenia; obesity; gastric cancer (GC); gastrectomy
ID HYDROXY-BETA-METHYLBUTYRATE; DIETARY-PROTEIN INTAKE; ESSENTIAL
   AMINO-ACIDS; LONG-TERM SURVIVAL; SKELETAL-MUSCLE; METABOLIC SYNDROME;
   POSTOPERATIVE COMPLICATIONS; COMPUTED-TOMOGRAPHY; VISCERAL FAT;
   PROGNOSTIC-SIGNIFICANCE
AB Malnutrition is a critical problem in patients with gastric cancer (GC); however, no universally accepted marker that is convenient for clinical use has been defined. Recently, body composition has attracted considerable attention as a means to assess nutrition status in patients with cancer. The clinical role of skeletal muscle mass has also been increasingly recognized. In patients with GC, sarcopenia, which is the loss of skeletal musde mass, was found to be significantly associated with increased post-surgical complications including hospital stay, healthcare costs, and poor survival. In addition, sarcopenic obesity, which combines the health risks of obesity and sarcopenia, is recognized as a strong risk factor for poor short- and long-term outcomes following gastrectomy. The mechanism linking sarcopenia to worse postoperative outcomes remains unclear; however, skeletal muscle has been found to act as an endocrine organ that produces substances affecting the immune system. In addition, sarcopenia was reported to be associated with toxicity and termination of chemotherapy Patients with sarcopenia may be unable to react appropriately to the stress of gastrectomy and perioperative chemotherapy. To improve the short- and long-term outcomes of patients with GC and sarcopenia, adequate energy and protein intake are necessary during resistance training. In the present study, we performed a literature review and presented a method to evaluate body composition, the relationship between skeletal muscle mass and GC, and perioperative nutrition and exercise therapy for patients with sarcopenia.
C1 [Nishigori, Tatsuto; Obama, Kazutaka; Sakai, Yoshiharu] Kyoto Univ, Grad Sch Med, Dept Surg, Kyoto, Japan.
C3 Kyoto University
RP Obama, K (corresponding author), Kyoto Univ, Grad Sch Med, Dept Surg, Sakyo Ku, 54 Kawahara Cho, Kyoto 6068507, Japan.
EM kobama@kuhp.kyoto-u.ac.jp
RI OBAMA, KAZUTAKA/AAW-8263-2021
OI Obama, Kazutaka/0000-0003-2924-6701
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NR 104
TC 25
Z9 27
U1 0
U2 43
PU AME PUBLISHING COMPANY
PI SHATIN
PA FLAT-RM C 16F, KINGS WING PLAZA 1, NO 3 KWAN ST, SHATIN, HONG KONG
   00000, PEOPLES R CHINA
EI 2415-1289
J9 TRANSL GASTROENT HEP
JI Transl. Gastroenterol. Hepatol.
PD APR
PY 2020
VL 5
AR 22
DI 10.21037/tgh.2019.10.13
PG 9
WC Gastroenterology & Hepatology
WE Emerging Sources Citation Index (ESCI)
SC Gastroenterology & Hepatology
GA KB7DB
UT WOS:000506650100010
PM 32258526
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Abu-Elsaad, N
   El-Karef, A
AF Abu-Elsaad, Nashwa
   El-Karef, Amr
TI The Falconoid Luteolin Mitigates the Myocardial Inflammatory Response
   Induced by High-Carbohydrate/High-Fat Diet in Wistar Rats
SO INFLAMMATION
LA English
DT Article
DE luteolin; cardiomyopathy; TNF-alpha; IL-18; high-fat diet
ID DOXORUBICIN-INDUCED TOXICITY; NECROSIS-FACTOR-ALPHA; METABOLIC SYNDROME;
   TNF-ALPHA; CONTRACTILE FUNCTION; ADIPOSE-TISSUE; ANTIOXIDANT;
   FLAVONOIDS; INTERLEUKIN-18; PROTECTS
AB Luteolin is a major component of many medicinal plants and traditional medicines. The current study aims at testing its protective effect against high-carbohydrate/high-fat (HCHF) diet-induced cardiac dysfunction in rats. Male Wistar rats were divided into six groups as follows: control group that received standard rat chow, group received HCHF diet (similar to 30% carbohydrate and 42% fat) daily for 16 weeks, and four groups received HCHF diet concurrently with luteolin (10, 25, 50 or 100 mg/kg; 10% w/v suspension in 0.9% NaCl) daily from the first week by oral gavage. Body weight was measured weekly. At the end of the study, histopathological examinations of stained heart sections were carried out. Lipid profile, oxidative stress, and cardiac function biomarkers were measured. Furthermore, neurohumoral mediators and inflammatory cytokines (TNF-alpha, IL-18) were assigned. Results showed a significant improvement in cardiac function, tissue integrity, and a decrease in the compensatory neurohumoral mediators by luteolin 50 and 100 mg/kg. In addition, a significant (P < 0.05) decrease in collagen deposition, fibrosis percentage, lipid peroxidation, and inflammatory cells (macrophages and lymphocytes) infiltration was observed. Tested doses of luteolin decreased lipid peroxidation and elevated the endogenous antioxidant biomarkers (reduced glutathione and superoxide dismutase) significantly (P < 0.05). Finally, luteolin decreased TNF-alpha and IL-18 (P < 0.001) in a dose-dependent manner. It can be concluded that luteolin has a cardioprotective effect against HCHF diet-induced myocardial inflammation through antioxidant anti-inflammatory mechanisms.
C1 [Abu-Elsaad, Nashwa] Mansoura Univ, Dept Pharmacol & Toxicol, Fac Pharm, Mansoura, Egypt.
   [El-Karef, Amr] Mansoura Univ, Dept Pathol, Fac Med, Mansoura 35516, Egypt.
C3 Egyptian Knowledge Bank (EKB); Mansoura University; Egyptian Knowledge
   Bank (EKB); Mansoura University
RP Abu-Elsaad, N (corresponding author), Mansoura Univ, Dept Pharmacol & Toxicol, Fac Pharm, Mansoura, Egypt.
EM nosha.samaa@gmail.com; aelkaref@gmail.com
RI Abu-Elsaad, Nashwa/MDT-7640-2025
OI Abu Elsaad, Nashwa/0000-0002-7515-0383
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NR 52
TC 24
Z9 26
U1 1
U2 20
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0360-3997
EI 1573-2576
J9 INFLAMMATION
JI Inflammation
PD FEB
PY 2018
VL 41
IS 1
BP 221
EP 231
DI 10.1007/s10753-017-0680-8
PG 11
WC Cell Biology; Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Immunology
GA FS6GP
UT WOS:000419896200023
PM 29047036
DA 2025-06-11
ER

PT J
AU Federico, A
   Dallio, M
   Caprio, GG
   Gravina, AG
   Picascia, D
   Masarone, M
   Persico, M
   Loguercio, C
AF Federico, Alessandro
   Dallio, Marcello
   Caprio, Giuseppe Gerardo
   Gravina, Antonietta Gerarda
   Picascia, Desiree
   Masarone, Mario
   Persico, Marcello
   Loguercio, Carmela
TI Qualitative and Quantitative Evaluation of Dietary Intake in Patients
   with Non-Alcoholic Steatohepatitis
SO NUTRIENTS
LA English
DT Article
DE non-alcoholic steatohepatitis; dietary intake; micronutrients;
   macronutrients
ID FATTY LIVER-DISEASE; VITAMIN-D SUPPLEMENTATION; INSULIN-RESISTANCE;
   CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; OXIDATIVE STRESS; NUTRIENT
   INTAKE; ACIDS; ASSOCIATION; HABITS
AB There are very few reports about the intake of nutrients for the development or progression of non-alcoholic steatohepatitis (NASH). The aim of this study was to identify the dietary habits and the nutrient intake in patients with NASH, in comparison to chronic hepatitis C (HCV)-related patients. We prospectively evaluated the intake of macronutrients and micronutrients in 124 NAFLD and 162 HCV patients, compared to 2326 subjects as a control group. We noticed major differences in macro- and micronutrients intakes in NASH and HCV patients compared to controls. Proteins, carbohydrate (glucose, fructose, sucrose, maltose and amide), saturated fatty acid (SFA), monounsaturated fatty acid (MUFA), folic acid, vitamin A and C (p < 0.0001), and thiamine (p < 0.0003) ingestion was found to be higher in patients with NASH, while total lipids, polyunsaturated fatty acid (PUFA), riboflavin and vitamin B6 daily intake were lower compared to controls (p < 0.0001). Similarly, NASH patients had significantly reduced carbohydrate intake (p < 0.0001) and an increased intake of calcium (p < 0.0001) compared to HCV positive patients. Finally, we showed in NASH males an increase in the intake of SFA, PUFA, soluble carbohydrates (p < 0.0001) and a decrease in the amount of fiber (p < 0.0001) compared to control males. In NASH female population, we showed an increase of daily total calories, SFA, MUFA, soluble carbohydrates, starch and vitamin D ingested (p < 0.0001) with a reduction of fibers and calcium (p < 0.0001) compared to control females. This study showed how NASH patients' diets, in both male and females, is affected by a profound alteration in macroand micronutrients intake.
C1 [Federico, Alessandro; Dallio, Marcello; Caprio, Giuseppe Gerardo; Gravina, Antonietta Gerarda; Picascia, Desiree; Loguercio, Carmela] Univ Campania L Vanvitelli, Dept Clin & Expt Med, Via Pansini 5, I-80131 Naples, Italy.
   [Masarone, Mario; Persico, Marcello] Univ Salerno, Dept Med & Surg, Via Salvador Allende, I-84081 Salerno, Italy.
C3 Universita della Campania Vanvitelli; University of Salerno
RP Federico, A (corresponding author), Univ Campania L Vanvitelli, Dept Clin & Expt Med, Via Pansini 5, I-80131 Naples, Italy.
EM alessandro.federico@unicampania.it; marcello.dallio@gmail.com;
   giuseppegerardo.caprio@hotmail.it; antonietta.gravina@yahoo.it;
   dpicascia90@gmail.com; mmasarone@unisa.it; mpersico@unisa.it;
   carmelina.loguercio@unicampania.it
RI persico, marcello/AAB-3562-2019; Federico, Alessandro/AAB-3893-2019;
   Gravina, Antonietta Gerarda/AAC-1528-2019; Dallio,
   Marcello/ABG-7693-2020; Masarone, Mario/H-8633-2017
OI DALLIO, MARCELLO/0000-0003-4153-815X; Persico,
   Marcello/0000-0002-1399-6498; Masarone, Mario/0000-0003-0550-8201;
   Gravina, Antonietta Gerarda/0000-0001-8049-0115; Federico,
   Alessandro/0000-0002-0885-0793
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NR 78
TC 20
Z9 20
U1 1
U2 11
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD OCT
PY 2017
VL 9
IS 10
AR 1074
DI 10.3390/nu9101074
PG 16
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA FM0DM
UT WOS:000414629900030
PM 28956816
OA Green Submitted, gold, Green Published
DA 2025-06-11
ER

PT J
AU Cobbina, E
   Akhlaghi, F
AF Cobbina, Enoch
   Akhlaghi, Fatemeh
TI Non-alcoholic fatty liver disease (NAFLD) - pathogenesis,
   classification, and effect on drug metabolizing enzymes and transporters
SO DRUG METABOLISM REVIEWS
LA English
DT Review
DE Non-alcoholic fatty liver disease; steatosis; non-alcoholic
   steatohepatitis; diabetes; drug metabolizing enzymes; transporters;
   cytochrome P450
ID CYTOCHROME-P450 2E1 ACTIVITY; PREGNANE-X-RECEPTOR; DIABETES-MELLITUS;
   INSULIN-RESISTANCE; HEPATIC STEATOSIS; IN-VITRO; TRANSCRIPTIONAL
   REGULATION; NATURAL-HISTORY; ACID REGULATION; DOWN-REGULATION
AB Non-alcoholic fatty liver disease (NAFLD) is a spectrum of liver disorders. It is defined by the presence of steatosis in more than 5% of hepatocytes with little or no alcohol consumption. Insulin resistance, the metabolic syndrome or type 2 diabetes and genetic variants of PNPLA3 or TM6SF2 seem to play a role in the pathogenesis of NAFLD. The pathological progression of NAFLD follows tentatively a three-hit process namely steatosis, lipotoxicity and inflammation. The presence of steatosis, oxidative stress and inflammatory mediators like TNF- and IL-6 has been implicated in the alterations of nuclear factors such as CAR, PXR, PPAR- in NAFLD. These factors may result in altered expression and activity of drug metabolizing enzymes (DMEs) or transporters.Existing evidence suggests that the effect of NAFLD on CYP3A4, CYP2E1 and MRP3 is more consistent across rodent and human studies. CYP3A4 activity is down-regulated in NASH whereas the activity of CYP2E1 and the efflux transporter MRP3 is up-regulated. However, it is not clear how the majority of CYPs, UGTs, SULTs and transporters are influenced by NAFLD either in vivo or in vitro. The alterations associated with NAFLD could be a potential source of drug variability in patients and could have serious implications for the safety and efficacy of xenobiotics. In this review, we summarize the effects of NAFLD on the regulation, expression and activity of major DMEs and transporters. We also discuss the potential mechanisms underlying these alterations.
C1 [Cobbina, Enoch; Akhlaghi, Fatemeh] Univ Rhode Isl, Dept Biomed & Pharmaceut Sci, Clin Pharmacokinet Res Lab, Kingston, RI 02881 USA.
C3 University of Rhode Island
RP Akhlaghi, F (corresponding author), Univ Rhode Isl, Clin Pharmacokinet Res Lab, Off 495 A,7 Greenhouse Rd, Kingston, RI 02881 USA.
EM fatemeh@uri.edu
RI Akhlaghi, Fatemeh/U-9574-2019
OI Akhlaghi, Fatemeh/0000-0002-3946-7615
FU National Institutes of Health [R15 GM101599]
FX The authors gratefully acknowledge the support of grant # R15 GM101599
   from the National Institutes of Health.
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PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0360-2532
EI 1097-9883
J9 DRUG METAB REV
JI Drug Metab. Rev.
PY 2017
VL 49
IS 2
BP 197
EP 211
DI 10.1080/03602532.2017.1293683
PG 15
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA EY8NL
UT WOS:000404251600004
PM 28303724
OA Green Accepted
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Hsu, YC
   Chang, CW
   Lee, HL
   Chuang, CC
   Chiu, HC
   Li, WY
   Horng, JT
   Fu, E
AF Hsu, Yung-Chuang
   Chang, Cheng-Wei
   Lee, Hsin-Lin
   Chuang, Chuan-Chung
   Chiu, Hsien-Chung
   Li, Wan-Yun
   Horng, Jorng-Tzong
   Fu, Earl
TI Association between History of Dental Amalgam Fillings and Risk of
   Parkinson's Disease: A Population-Based Retrospective Cohort Study in
   Taiwan
SO PLOS ONE
LA English
DT Article
ID CLINICAL COMORBIDITY INDEX; ALZHEIMERS-DISEASE; METABOLIC SYNDROME;
   NATIONWIDE COHORT; OXIDATIVE STRESS; ROOT-CARIES; MERCURY; HEALTH;
   PREVALENCE; NEURODEGENERATION
AB The impact of dental amalgam on the development of Parkinson's disease (PD) is still uncertain, although a positive association between dental amalgam and PD has been found in a few case-control studies. The patients with amalgam fillings restored between 2000 and 2008 were identified by using the National Health Insurance Research Database (NHIRD) in Taiwan. The same number of patients who had no new amalgam filling restored was matched by sex, age, and treatment date. Both cohorts were followed up from the treatment date until the date of diagnosis of PD, death, or the end of the year 2008. The individuals who received amalgam fillings had a significantly higher risk of PD afterward (adjusted hazard ratio [HR]=1.583, 95% confidence interval [CI]=1.122-2.234, p=0.0089) than those who did not. In the individuals who received amalgam fillings, being diagnosed with diabetes or hyperlipidemia demonstrated a significantly lower HR of PD occurrence than in the patients without diabetes or hyperlipidemia (HR=0.449, 95% CI=0.254-0.794, p=0.0059; HR=0.445, 95% CI=0.260-0.763, p=0.0032) after adjusting for comorbidities and Charlson-Deyo Comorbidity Index (CCI) scores. Meanwhile, hypertension increased the hazard risk of PD (HR=1.645, 95% CI=1.098-2.464, p=0.0159). The patients exposed to dental amalgam fillings were 1.583 times more likely to have PD afterward compared to their non-exposed counterparts after adjusting for comorbidities and CCI scores.
C1 [Hsu, Yung-Chuang; Lee, Hsin-Lin; Chuang, Chuan-Chung; Chiu, Hsien-Chung; Fu, Earl] Tri Serv Gen Hosp, Dept Dent, Taipei, Taiwan.
   [Hsu, Yung-Chuang; Lee, Hsin-Lin; Chuang, Chuan-Chung; Chiu, Hsien-Chung; Fu, Earl] Natl Def Med Ctr, Taipei, Taiwan.
   [Chang, Cheng-Wei] Hsing Wu Univ, Dept Informat Management, New Taipei, Taiwan.
   [Li, Wan-Yun; Horng, Jorng-Tzong] Natl Cent Univ, Dept Comp Sci & Informat Engn, Chungli, Taiwan.
   [Horng, Jorng-Tzong] Asia Univ Taiwan, Dept Biomed Informat, Populat Hlth & Clin Informat Res Grp, Taichung, Taiwan.
C3 Tri-Service General Hospital; National Defense Medical Center; National
   Central University; Asia University Taiwan
RP Fu, E (corresponding author), Tri Serv Gen Hosp, Dept Dent, Taipei, Taiwan.; Fu, E (corresponding author), Natl Def Med Ctr, Taipei, Taiwan.
EM dentalab@tpts5.seed.net.tw
RI li, wanyun/HZH-5867-2023
OI Fu, Earl/0000-0003-0637-0208
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NR 45
TC 31
Z9 32
U1 0
U2 16
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD DEC 1
PY 2016
VL 11
IS 12
AR e0166552
DI 10.1371/journal.pone.0166552
PG 12
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA EE3JC
UT WOS:000389482700029
PM 27906991
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Stefanaki, C
   Peppa, M
   Boschiero, D
   Chrousos, GP
AF Stefanaki, Charikleia
   Peppa, Melpomeni
   Boschiero, Dario
   Chrousos, George P.
TI Healthy overweight/obese youth: early osteosarcopenic obesity features
SO EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
LA English
DT Article
DE bio-impedance; body composition; fat mass; muscle mass; osteopenia;
   osteosarcopenic obesity; sarcopenia; young adults
ID METABOLIC SYNDROME; OLDER INDIVIDUALS; FAT DISTRIBUTION; MUSCLE
   FUNCTION; BODY; INFLAMMATION; BIOIMPEDANCE; ACTIVATION; GUIDELINES;
   SARCOPENIA
AB BackgroundOsteosarcopenic obesity was recently described as a variant phenotype of obesity, mainly observed in old age. This nested case-control study was performed to detect the differences in body composition between young, healthy overweight/obese and healthy lean populations of both genders. Our null hypothesis was that except for the fat mass, there would be absence of body composition differences, namely skeletal muscle and bone masses, between the groups.
   MethodsWe used an advanced bio-impedance device to determine the body composition and measured circulating CRP (hsCRP) and diurnal salivary cortisol concentrations, as indices of inflammation and chronic stress, respectively. Overall, 2551 subjects aged 18-21 years participated in the study.
   ResultsThe healthy lean group included 1072 participants [900 males (84%) and 172 females (16%)], and the healthy overweight/obese group included 1479 participants [74 males (5%) and 1405 females (95%)]. Healthy overweight/obese participants presented with an increased fat mass (P < 0001), as expected, but lower muscle (P < 0001) and bone (P < 0001) masses than lean controls. These findings were accompanied by increased extracellular water compartments, circulating hsCRP levels and evening salivary cortisol concentrations in the healthy overweight/obese group.
   ConclusionsOur study suggests that osteosarcopenic' elements exist even in very young populations. These may represent a precursor' or forme fruste of the osteosarcopenic obesity phenotype in young healthy overweight/obese subjects, who may progressively develop osteosarcopenia in its full form at an older age. Our study highlights the significance of body composition analysis in medical practice, improving prevention and alleviating later health-related economic burden.
C1 [Stefanaki, Charikleia; Chrousos, George P.] Univ Athens, Dept Pediat 1, Athens, Greece.
   [Stefanaki, Charikleia; Chrousos, George P.] Univ Athens, Choreme Res Lab, Athens, Greece.
   [Peppa, Melpomeni] Univ Athens, Endocrine & Metab Bone Disorders Unit, Dept Internal Propaedeut Med 2, Res Inst, Athens, Greece.
   [Peppa, Melpomeni] Univ Athens, Ctr Diabet, Attikon Univ Hosp, Athens Med Sch, Athens, Greece.
   [Boschiero, Dario] BIOTEKNA Co, Venice, Italy.
   [Chrousos, George P.] Acad Athens, Biomed Res Fdn, Athens, Greece.
C3 National & Kapodistrian University of Athens; National & Kapodistrian
   University of Athens; National & Kapodistrian University of Athens;
   University Hospital Attikon; National & Kapodistrian University of
   Athens; Academy of Athens
RP Chrousos, GP (corresponding author), Univ Athens, Dept Pediat 1, Athens, Greece.; Chrousos, GP (corresponding author), Univ Athens, Choreme Res Lab, Athens, Greece.; Chrousos, GP (corresponding author), Acad Athens, Biomed Res Fdn, Athens, Greece.
EM chrousos@gmail.com
RI Chrousos, George/G-8702-2011; Stefanaki, Charikleia/G-6653-2012
OI Stefanaki, Charikleia/0000-0003-1634-701X
FU BIOTEKNA Srl; Operational Programme 'Competitiveness and
   Entrepreneurship' (OPCE II) of the General Secretariat for Research and
   Technology (GSRT)
FX This study was funded by BIOTEKNA Srl and in part by the Operational
   Programme 'Competitiveness and Entrepreneurship' (OPCE II) of the
   General Secretariat for Research and Technology (GSRT), Praxe: 'Creation
   of Innovation Clusters - A Greek Product, a Single Market: The Planet',
   with project title 'Greek Life Sciences Cluster BIONIAN', Subcontract:
   'Determination of Biomedical Factors with Bio-impedance Measurements and
   Implementation of an Integrative Data Collection System'.
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NR 48
TC 51
Z9 53
U1 3
U2 18
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0014-2972
EI 1365-2362
J9 EUR J CLIN INVEST
JI Eur. J. Clin. Invest.
PD SEP
PY 2016
VL 46
IS 9
BP 767
EP 778
DI 10.1111/eci.12659
PG 12
WC Medicine, General & Internal; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Research & Experimental Medicine
GA DW3DA
UT WOS:000383521100002
PM 27434725
DA 2025-06-11
ER

PT J
AU Liang, XY
   Zhang, T
   Shi, LY
   Kang, C
   Wan, J
   Zhou, Y
   Zhu, JD
   Mi, MT
AF Liang, Xinyu
   Zhang, Ting
   Shi, Linying
   Kang, Chao
   Wan, Jing
   Zhou, Yong
   Zhu, Jundong
   Mi, Mantian
TI Ampelopsin protects endothelial cells from hyperglycemia-induced
   oxidative damage by inducing autophagy via the AMPK signaling pathway
SO BIOFACTORS
LA English
DT Article
DE diabetes; ampelopsin; autophagy; endothelial cell; AMPK
ID DIABETIC COMPLICATIONS; METABOLIC SYNDROME; CARDIAC AUTOPHAGY; STRESS;
   APOPTOSIS; DIHYDROMYRICETIN; PREVENTION; DIET
AB Diabetic angiopathy is a major diabetes-specific complication that often begins with endothelial dysfunction induced by hyperglycemia; however, the pathological mechanisms of this progression remain unclear. Ampelopsin is a natural flavonol that has strong antioxidant activity, but little information is available regarding its antidiabetic effect. This study focused on the effect of ampelopsin on hyperglycemia-induced oxidative damage and the underlying mechanism of this effect in human umbilical vein endothelial cells (HUVECs). We found that hyperglycemia impaired autophagy in HUVECs through the inhibition of AMP-activated protein kinase (AMPK), which directly led to endothelial cell damage. Ampelopsin significantly attenuated the detrimental effect of hyperglycemia-induced cell dysfunction in a concentration-dependent manner in HUVECs. Ampelopsin significantly upregulated LC3-II, Beclin1, and Atg5 protein levels but downregulated p62 protein levels in HUVECs. Transmission electron microscopy and confocal microscopy indicated that ampelopsin notably induced autophagosomes and LC3-II dots, respectively. Additionally, the autophagy-specific inhibitor 3-MA, as well as Atg5 and Beclin1 siRNA pretreatment, markedly attenuated ampelopsin-induced autophagy, which subsequently abolished the protective effect of ampelopsin against hyperglycemia in HUVECs. Moreover, ampelopsin also increased AMPK activity and inhibited mTOR (mammalian target of rapamycin) complex activation. Ampelopsin-induced autophagy was attenuated by the AMPK antagonist compound C but strengthened by the AMPK agonist AICAR (5-minoimidazole-4-carboxamide ribonucleotide). Furthermore, AMPK siRNA transfection eliminated ampelopsin's alleviation of cell injury induced by hyperglycemia. The protective effect of ampelopsin against hyperglycemia-induced cell damage, which functions by targeting autophagy via AMPK activation, makes it a promising pharmacological treatment for type-2 diabetes. (c) 2015 BioFactors, 41(6):463-475, 2015
C1 [Liang, Xinyu; Zhang, Ting; Shi, Linying; Kang, Chao; Wan, Jing; Zhou, Yong; Zhu, Jundong; Mi, Mantian] Third Mil Med Univ, Inst Mil Prevent Med, Res Ctr Nutr & Food Safety, Chongqing Key Lab Nutr & Food Safety, Chongqing 400038, Peoples R China.
C3 Army Medical University
RP Zhu, JD (corresponding author), Third Mil Med Univ, Inst Mil Prevent Med, Res Ctr Nutr & Food Safety, 30th Gaotanyan Main St, Chongqing 400038, Peoples R China.
EM zjdnfs@126.com; Mantianmi@Hotmail.Com
RI Zhang, Tingting/HZM-2762-2023; kang, chao/HJI-4257-2023
OI kang, chao/0000-0001-9602-9251
FU National Natural Science Foundation of China [81372975]; special fund of
   Chongqing key laboratory (CSTC) for Nutrition and Food Safety
FX All authors contributed to the final manuscript version. Ting Zhang,
   Xinyu Liang, Jundong Zhu, and Mantian Mi conceived and designed the
   experiments. Xinyu Liang, Ting Zhang, Linying Shi, Chao Kang, and Jing
   Wan performed the experiments. Ting Zhang, Xinyu Liang, and Yong Zhou
   analyzed the data and wrote the article. Jundong Zhu and Mantian Mi had
   the primary responsibility for the final content. This work was
   supported by the research grant from National Natural Science Foundation
   of China (grant number: 81372975) and the special fund of Chongqing key
   laboratory (CSTC) for Nutrition and Food Safety.
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NR 35
TC 36
Z9 42
U1 0
U2 32
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0951-6433
EI 1872-8081
J9 BIOFACTORS
JI Biofactors
PD NOV-DEC
PY 2015
VL 41
IS 6
BP 463
EP 475
DI 10.1002/biof.1248
PG 13
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA DB0JJ
UT WOS:000368194100009
PM 26644014
DA 2025-06-11
ER

PT J
AU Renaud, HJ
   Cui, JLY
   Lu, H
   Klaassen, CD
AF Renaud, Helen J.
   Cui, Julia Y.
   Lu, Hong
   Klaassen, Curtis D.
TI Effect of Diet on Expression of Genes Involved in Lipid Metabolism,
   Oxidative Stress, and Inflammation in Mouse Liver-Insights into
   Mechanisms of Hepatic Steatosis
SO PLOS ONE
LA English
DT Article
ID CALORIE RESTRICTION; ACID; CHOLESTEROL; FAT; DISEASE; MICE; RECEPTOR;
   STEATOHEPATITIS; CARBOHYDRATE; RESISTANCE
AB Nutritional intake is a fundamental determinant of health. Many studies have correlated excess caloric intake, as well as a high ratio of n-6:n-3 fatty acids, with detrimental health outcomes, such as the metabolic syndrome. In contrast, low-calorie diets have beneficial health effects. Despite these associations, our understanding of the causal relationship between diet and health remains largely elusive. The present study examined the molecular changes elicited by nine diets with varying fat, sugar, cholesterol, omega-3 fatty acids, omega-6 fatty acids, and calories in C57BL/6 male mice. Microarray analyses were conducted on liver samples from three mice per diet and detected 20,449 genes of which 3,734 were responsive to changes in dietary components. Principal component analysis showed that diet restriction correlated the least with the other diets and also affected more genes than any other diet. Interestingly, Gene Set Enrichment Analysis (GSEA) identified gene sets involved in glutathione metabolism, immune response, fatty acid metabolism, cholesterol metabolism, ABC transporters, and oxidative phosphorylation as being highly responsive to changes in diet composition. On the gene level, this study reveals novel findings such as the induction of the drug efflux pump Abcb1a (p-glycoprotein) by diet restriction and an atherogenic diet, as well as the suppression of the rate limiting step of bile acid synthesis, Cyp7a1, by a high fructose diet. This study provides considerable insight into the molecular changes incurred by a variety of diets and furthers our understanding of the causal relationships between diet and health.
C1 [Renaud, Helen J.; Cui, Julia Y.; Klaassen, Curtis D.] Univ Kansas, Med Ctr, Dept Internal Med, Kansas City, KS 66103 USA.
   [Lu, Hong] SUNY Syracuse, Dept Pharmacol, Syracuse, NY USA.
C3 University of Kansas; University of Kansas Medical Center; State
   University of New York (SUNY) System
RP Klaassen, CD (corresponding author), Univ Kansas, Med Ctr, Dept Internal Med, Kansas City, KS 66103 USA.
EM cklaasse@kumc.edu
FU NIH [ES009649]; Canadian Institutes of Health Research Fellowship
FX This work was supported by NIH grant ES009649. Helen J Renaud is
   supported by a Canadian Institutes of Health Research Fellowship. The
   funders had no role in study design, data collection and analysis,
   decision to publish, or preparation of the manuscript.
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NR 60
TC 65
Z9 73
U1 0
U2 34
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD FEB 14
PY 2014
VL 9
IS 2
AR e88584
DI 10.1371/journal.pone.0088584
PG 17
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA AA7IR
UT WOS:000331271500049
PM 24551121
OA Green Submitted, gold, Green Published
DA 2025-06-11
ER

PT J
AU Montaigne, D
   Marechal, X
   Lefebvre, P
   Modine, T
   Fayad, G
   Dehondt, H
   Hurt, C
   Coisne, A
   Koussa, M
   Remy-Jouet, I
   Zerimech, F
   Boulanger, E
   Lacroix, D
   Staels, B
   Neviere, R
AF Montaigne, David
   Marechal, Xavier
   Lefebvre, Philippe
   Modine, Thomas
   Fayad, Georges
   Dehondt, Helene
   Hurt, Christopher
   Coisne, Augustin
   Koussa, Mohamed
   Remy-Jouet, Isabelle
   Zerimech, Farid
   Boulanger, Eric
   Lacroix, Dominique
   Staels, Bart
   Neviere, Remi
TI Mitochondrial Dysfunction as an Arrhythmogenic Substrate
SO JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
LA English
DT Article
DE atrial fibrillation; cardiac surgery; diabetes; gene expression;
   mitochondria
ID DIABETIC HUMAN HEART; ATRIAL-FIBRILLATION; CARDIAC-SURGERY; METABOLISM;
   CHANNEL
AB Objectives This study sought to provide bedside evidence of the potential link between cardiac mitochondrial dysfunction and arrhythmia as reported in bench studies.
   Background Atrial fibrillation (AF) is a frequent complication of cardiac surgery. Underlying mechanisms of post-operative atrial fibrillation (POAF) remain largely unknown. Because cardiac mitochondrial dysfunction has been reported in clinical conditions with a high risk of POAF, we investigated whether a causal link exists between POAF onset and pre-operative function of cardiac mitochondria.
   Methods Pre-operative mitochondrial respiration and calcium retention capacity, respiratory complex activity, and myocardial oxidative stress were quantified in right atrial tissue from 104 consecutive patients with metabolic syndrome, in sinus rhythm, and undergoing coronary artery bypass graft surgery.
   Results In this high-risk population, POAF occurred in 44% of patients. Decreased pre-operative mitochondrial respiration and increased sensitivity to calcium-induced mitochondrial permeability transition pore opening were significantly associated with POAF. Adenosine diphosphate-stimulated mitochondrial respiration supported by palmitoyl-L-carnitine was significantly lower in POAF patients and remained independently associated with AF onset after adjustment for age, body mass index, heart rate, beta-blocker use, and statin medication (multivariate logistic regression coefficient per unit = -0.314 +/- 0.144; p = 0.028). Gene expression profile analysis identified a general downregulation of the mitochondria/oxidative phosphorylation gene cluster in pre-operative atrial tissue of patients in whom AF developed.
   Conclusions Our prospective study identifies an association between pre-operative mitochondrial dysfunction of the atrial myocardium and AF occurrence after cardiac surgery in patients with metabolic disease, providing novel insights into the link between mitochondria and arrhythmias in patients. (C) 2013 by the American College of Cardiology Foundation
C1 [Montaigne, David; Marechal, Xavier; Hurt, Christopher; Coisne, Augustin; Neviere, Remi] Univ Lille 2, Dept Physiol, Fac Med, EA 4484, F-59045 Lille, France.
   [Montaigne, David; Coisne, Augustin] Univ Hosp Lille, Serv Explorat Fonct CardioVasc, Lille, France.
   [Lefebvre, Philippe; Dehondt, Helene; Staels, Bart] Univ Lille 2, INSERM, U1011, EGID, F-59045 Lille, France.
   [Fayad, Georges; Koussa, Mohamed] Univ Hosp Lille, Dept Cardiovasc Surg, Lille, France.
   [Remy-Jouet, Isabelle] Univ Rouen, Inst Res & Innovat Biomed, INSERM, U1096, Rouen, France.
   [Zerimech, Farid] Univ Hosp Lille, Pathol & Biol Ctr, Div Biochem, Lille, France.
   [Boulanger, Eric] Lille Nord France Univ, Fac Med Lille, Lille, France.
   [Lacroix, Dominique] Univ Hosp Lille, Dept Cardiol, Lille, France.
C3 Universite de Lille; Universite de Lille; CHU Lille; Institut National
   de la Sante et de la Recherche Medicale (Inserm); Universite de Lille;
   Universite de Lille; CHU Lille; Universite de Rouen Normandie; Institut
   National de la Sante et de la Recherche Medicale (Inserm); Universite de
   Lille; CHU Lille; Universite de Lille; Universite de Lille; CHU Lille
RP Montaigne, D (corresponding author), Univ Lille 2, Dept Physiol, Fac Med, EA 4484, Pl Verdun, F-59045 Lille, France.
EM davidmontaigne@hotmail.com
RI Coisne, Augustin/AAV-6258-2020; Marechal, Xavier/R-5762-2018; modine,
   thomas/AAQ-4164-2021; Lefebvre, Philippe/F-2685-2010; Zerimech,
   Farid/B-5745-2011; montaigne, david/R-6066-2018; Staels,
   Bart/N-9497-2016; Coisne, Augustin/R-6567-2018
OI Zerimech, Farid/0000-0003-2964-1031; montaigne,
   david/0000-0002-2346-863X; Staels, Bart/0000-0002-3784-1503; BOULANGER,
   Eric/0000-0002-5204-2849; Dehondt, Helene/0000-0003-2900-4673; Coisne,
   Augustin/0000-0002-1662-7874; Neviere, Remi/0000-0002-7966-0110
FU Federation Francaise de Cardiologie; Centre Hospitalier Regional et
   Universitaire de Lille
FX Biochemistry Division, Pathology and Biology Center, University Hospital
   of Lille, Lille, France; # Vascular Aging Biology and Cardiovascular
   Repair, Faculty of Medicine Lille, Lille Nord de France University,
   Lille, France; and the **Department of Cardiology, University Hospital
   of Lille, Lille, France. Supported by Programme Projet Emergeant Region
   Nord, Pas de Calais, EA 4484, Universite Lille 2 and U1011 INSERM. Drs.
   Hurt and Coisne were supported by an educational grant from the
   Federation Francaise de Cardiologie and Centre Hospitalier Regional et
   Universitaire de Lille. Dr. Staels is a member of the Institut
   Universitaire de France. All other authors have reported that they have
   no relationships relevant to the contents of this paper to disclose.
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NR 24
TC 117
Z9 126
U1 0
U2 20
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0735-1097
EI 1558-3597
J9 J AM COLL CARDIOL
JI J. Am. Coll. Cardiol.
PD OCT 15
PY 2013
VL 62
IS 16
BP 1466
EP 1473
DI 10.1016/j.jacc.2013.03.061
PG 8
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 231NZ
UT WOS:000325425100013
PM 23644086
OA Bronze
DA 2025-06-11
ER

PT J
AU Guicciardi, ME
   Malhi, H
   Mott, JL
   Gores, GJ
AF Guicciardi, Maria Eugenia
   Malhi, Harmeet
   Mott, Justin L.
   Gores, Gregory J.
TI Apoptosis and Necrosis in the Liver
SO COMPREHENSIVE PHYSIOLOGY
LA English
DT Article
ID MITOCHONDRIAL PERMEABILITY TRANSITION; ENDOPLASMIC-RETICULUM STRESS;
   HEPATIC STELLATE CELL; MEDIATED HEPATOCYTE APOPTOSIS; SINUSOIDAL
   ENDOTHELIAL-CELLS; ISCHEMIA-REPERFUSION INJURY; ACID-INDUCED APOPTOSIS;
   PAN-CASPASE INHIBITOR; NF-KAPPA-B; ACETAMINOPHEN-INDUCED HEPATOTOXICITY
AB Because of its unique function and anatomical location, the liver is exposed to a multitude of toxins and xenobiotics, including medications and alcohol, as well as to infection by hepatotropic viruses, and therefore, is highly susceptible to tissue injury. Cell death in the liver occurs mainly by apoptosis or necrosis, with apoptosis also being the physiologic route to eliminate damaged or infected cells and to maintain tissue homeostasis. Liver cells, especially hepatocytes and cholangiocytes, are particularly susceptible to death receptor-mediated apoptosis, given the ubiquitous expression of the death receptors in the organ. In a quite unique way, death receptor-induced apoptosis in these cells is mediated by both mitochondrial and lysosomal permeabilization. Signaling between the endoplasmic reticulum and the mitochondria promotes hepatocyte apoptosis in response to excessive free fatty acid generation during the metabolic syndrome. These cell death pathways are partially regulated by microRNAs. Necrosis in the liver is generally associated with acute injury (i.e., ischemia/reperfusion injury) and has been long considered an unregulated process. Recently, a new form of "programmed" necrosis (named necroptosis) has been described: the role of necroptosis in the liver has yet to be explored. However, the minimal expression of a key player in this process in the liver suggests this form of cell death may be uncommon in liver diseases. Because apoptosis is a key feature of so many diseases of the liver, therapeutic modulation of liver cell death holds promise. An updated overview of these concepts is given in this article. (C) 2013 American Physiological Society.
C1 [Guicciardi, Maria Eugenia; Malhi, Harmeet; Gores, Gregory J.] Mayo Clin, Coll Med, Div Gastroenterol & Hepatol, Rochester, MN 55905 USA.
   [Mott, Justin L.] Univ Nebraska Med Ctr, Dept Biochem & Mol Biol, Omaha, NE USA.
   [Mott, Justin L.] Univ Nebraska Med Ctr, Eppley Canc Ctr, Omaha, NE USA.
C3 Mayo Clinic; University of Nebraska System; University of Nebraska
   Medical Center; University of Nebraska System; University of Nebraska
   Medical Center
RP Gores, GJ (corresponding author), Mayo Clin, Coll Med, Div Gastroenterol & Hepatol, Rochester, MN 55905 USA.
EM gores.gregory@mayo.edu
RI Mott, Justin/IYI-9175-2023
OI Mott, Justin/0000-0002-2927-6962
FU NIH [R01 DK41876, R01 DK63947, R03 DK092263]; State of Nebraska, Cancer
   and Smoking Disease Research Program [LB595]; Mayo Foundation
FX This work was supported by NIH grants R01 DK41876 and R01 DK63947 (to G.
   J. Gores), R03 DK092263 (to J. L. Mott), State of Nebraska LB595 Cancer
   and Smoking Disease Research Program (to J. L. Mott) and the Mayo
   Foundation. The secretarial assistance of Ms. Courtney Hoover is greatly
   appreciated.
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NR 406
TC 298
Z9 329
U1 0
U2 43
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 2040-4603
J9 COMPR PHYSIOL
JI Compr. Physiol.
PD APR
PY 2013
VL 3
IS 2
BP 977
EP 1010
DI 10.1002/cphy.c120020
PG 34
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA 157NY
UT WOS:000319906100015
PM 23720337
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Wang, YJ
   Tuomilehto, J
   Jousilahti, P
   Salomaa, V
   Li, B
   Antikainen, R
   Mähönen, M
   Katzmarzyk, PT
   Hu, G
AF Wang, Yujie
   Tuomilehto, Jaakko
   Jousilahti, Pekka
   Salomaa, Veikko
   Li, Bin
   Antikainen, Riitta
   Mahonen, Markku
   Katzmarzyk, Peter T.
   Hu, Gang
TI Serum γ-glutamyltransferase and the risk of heart failure in men and
   women in Finland
SO HEART
LA English
DT Article
ID VENTRICULAR SYSTOLIC DYSFUNCTION; CARDIOVASCULAR-DISEASE MORTALITY;
   PERSISTENT ORGANIC POLLUTANTS; NUTRITION EXAMINATION SURVEY; COFFEE
   CONSUMPTION LOWERS; TIME PHYSICAL-ACTIVITY; OXIDATIVE STRESS; METABOLIC
   SYNDROME; AUSTRIAN ADULTS; NATIONAL-HEALTH
AB Objectives To evaluate the association of serum.-glutamyltransferase (GGT) levels with heart failure (HF) risk in the Finnish population.
   Design Prospective population-based cohort study.
   Setting The present study, which is a part of FINRISK study, was carried out in Finland. Subject study cohorts included 18 353 Finnish men and 19 726 women who were 25-74 years of age and free of HF at baseline. Main outcome measures HF (636 men and 445 women) during a mean follow-up of 14.5 years.
   Results Baseline measurement of different levels of serum GGT was used to predict incident HF. The multivariable-adjusted (age, sex, study area, study year, smoking, education, alcohol consumption, physical activity, valvular heart disease, body mass index (BMI), systolic blood pressure, total cholesterol at baseline, myocardial infarction and diabetes at baseline and during follow-up) HRs of HF at five GGT groups (using the 25th, 50th, 75th and 90th percentiles) were 1.00, 1.16 (95% CI: 0.97 to 1.38), 1.20 (1.00 to 1.45), 1.29 (1.04 to 1.60) and 1.82 (1.45 to 2.29) (P-trend< 0.001). Stratification by smoking status, alcohol consumption and BMI gave similar results, while stronger association was observed among subjects aged <60 years (P-trend=0.001) compared with subjects 60+ years of age (P-trend=0.173).
   Conclusions Moderate to high levels of serum GGT (from the 50th to the 90th percentiles) were significantly associated with incident HF in men and women in Finland, and the predictive power was stronger in subjects aged <60 years.
C1 [Hu, Gang] Pennington Biomed Res Ctr, Chron Dis Epidemiol Lab, Baton Rouge, LA 70808 USA.
   [Wang, Yujie] Louisiana State Univ, AgCtr, Human Nutr & Food Div, Sch Human Ecol, Baton Rouge, LA 70803 USA.
   [Wang, Yujie; Li, Bin] Louisiana State Univ, AgCtr, Dept Expt Stat, Baton Rouge, LA 70803 USA.
   [Tuomilehto, Jaakko; Mahonen, Markku] Univ Helsinki, Dept Publ Hlth, Helsinki, Finland.
   [Tuomilehto, Jaakko; Jousilahti, Pekka; Salomaa, Veikko] Natl Inst Hlth & Welf, Dept Hlth Promot & Chron Dis Prevent, Helsinki, Finland.
   [Antikainen, Riitta] Oulu Univ, Oulu, Finland.
   [Antikainen, Riitta] Oulu City Hosp, Unit Gen Practice Geriatr, Oulu, Finland.
   [Antikainen, Riitta] Inst Hlth Sci, Oulu, Finland.
C3 Louisiana State University System; Louisiana State University;
   Pennington Biomedical Research Center; Louisiana State University
   System; Louisiana State University; Louisiana State University System;
   Louisiana State University; University of Helsinki; Finland National
   Institute for Health & Welfare; University of Oulu
RP Hu, G (corresponding author), Pennington Biomed Res Ctr, Chron Dis Epidemiol Lab, 6400 Perkins Rd, Baton Rouge, LA 70808 USA.
EM gang.hu@pbrc.edu
RI tuomilehto, jaakko/E-6504-2011; Wang, Yujie/L-9676-2017; Salomaa,
   Veikko/AEO-8209-2022; Hu, Gang/V-7947-2019; Hu, Gang/N-1971-2017;
   Katzmarzyk, Peter/N-1974-2017
OI Hu, Gang/0000-0002-6172-8017; Katzmarzyk, Peter/0000-0002-9280-6022
FU Finnish Academy [108297, 118065]; Special Research Funds of the Social
   Welfare and Health Board, City of Oulu
FX This work was supported by grants from the Finnish Academy (108297 and
   118065), and Special Research Funds of the Social Welfare and Health
   Board, City of Oulu.
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NR 29
TC 41
Z9 41
U1 0
U2 22
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 1355-6037
J9 HEART
JI Heart
PD FEB
PY 2013
VL 99
IS 3
BP 163
EP 167
DI 10.1136/heartjnl-2012-302972
PG 5
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 063MB
UT WOS:000313002100005
PM 23144292
OA Bronze
DA 2025-06-11
ER

PT J
AU Pal, M
   Wunderlich, CM
   Spohn, G
   Brönneke, HS
   Schmidt-Supprian, M
   Wunderlich, FT
AF Pal, Martin
   Wunderlich, Claudia M.
   Spohn, Gabriele
   Broenneke, Hella S.
   Schmidt-Supprian, Marc
   Wunderlich, F. Thomas
TI Alteration of JNK-1 Signaling in Skeletal Muscle Fails to Affect Glucose
   Homeostasis and Obesity-Associated Insulin Resistance in Mice
SO PLOS ONE
LA English
DT Article
ID NECROSIS-FACTOR-ALPHA; ACTIVATED PROTEIN-KINASES; JUN NH2-TERMINAL
   KINASE; NF-KAPPA-B; METABOLIC SYNDROME; IKK-BETA; RECEPTOR;
   PHOSPHORYLATION; INHIBITION; STRESS
AB Obesity and associated metabolic disturbances, such as increased circulating fatty acids cause prolonged low grade activation of inflammatory signaling pathways in liver, skeletal muscle, adipose tissue and even in the CNS. Activation of inflammatory pathways in turn impairs insulin signaling, ultimately leading to obesity-associated type 2 diabetes mellitus. Conventional JNK-1 knock out mice are protected from high fat diet-induced insulin resistance, characterizing JNK-1-inhibition as a potential approach to improve glucose metabolism in obese patients. However, the cell type-specific role of elevated JNK-1 signaling as present during the course of obesity has not been fully elucidated yet. To investigate the functional contribution of altered JNK-1 activation in skeletal muscle, we have generated a ROSA26 insertion mouse strain allowing for Cre-activatable expression of a JNK-1 constitutive active construct (JNK(C)). To examine the consequence of skeletal muscle-restricted JNK-1 overactivation in the development of insulin resistance and glucose metabolism, JNK(C) mice were crossed to Mck-Cre mice yielding JNK(SM-C) mice. However, despite increased muscle-specific JNK activation, energy homeostasis and glucose metabolism in JNK(SM-C) mice remained largely unaltered compared to controls. In line with these findings, obese mice with skeletal muscle specific disruption of JNK-1, did not affect energy and glucose homeostasis. These experiments indicate that JNK-1 activation in skeletal muscle does not account for the major effects on diet-induced, JNK-1-mediated deterioration of insulin action and points towards a so far underappreciated role of JNK-1 in other tissues than skeletal muscle during the development of obesity-associated insulin resistance.
C1 [Pal, Martin; Wunderlich, Claudia M.; Spohn, Gabriele; Wunderlich, F. Thomas] Univ Cologne, Inst Genet, Max Planck Inst Neurol Res, D-50931 Cologne, Germany.
   [Pal, Martin; Wunderlich, Claudia M.; Spohn, Gabriele; Wunderlich, F. Thomas] CMMC, Cologne, Germany.
   [Broenneke, Hella S.] Cologne Excellence Cluster Cellular Stress Respon, Mouse Phenotyping Core Facil, Cologne, Germany.
   [Schmidt-Supprian, Marc] Max Planck Inst Biochem, Munich, Germany.
C3 Max Planck Society; University of Cologne; University of Cologne;
   University of Cologne; Max Planck Society
RP Wunderlich, FT (corresponding author), Univ Cologne, Inst Genet, Max Planck Inst Neurol Res, D-50931 Cologne, Germany.
EM Thomas.wunderlich@uni-koeln.de
RI Schmidt-Supprian, Marc/F-5893-2011; Pal, Martin/AAL-8685-2020
OI Pal, Martin/0000-0002-1563-5426
FU DFG [SFB 832 A15, Z3, BR 1492/7-1]; Center for Molecular Medicine
   Cologne (CMMC) [D1, B2]; Cluster of Excellence Cellular Stress Responses
   in Aging-Associated Diseases (CECAD); European Union
   [FP7-HEALTH-2009-241592]; Competence Network for Adipositas
   (Neurotarget); Federal Ministry of Education and Research [FKZ01GIO845]
FX This work was supported by the DFG through SFB 832 A15 to FTW and Z3 to
   JCB, the Center for Molecular Medicine Cologne (CMMC) (D1 to JCB, B2 to
   FTW), the Cluster of Excellence Cellular Stress Responses in
   Aging-Associated Diseases (CECAD), the European Union
   (FP7-HEALTH-2009-241592, EurOCHIP, to JCB), the DFG (BR 1492/7-1 to
   JCB), and the Competence Network for Adipositas (Neurotarget) funded by
   the Federal Ministry of Education and Research (FKZ01GIO845 to JCB). The
   funders had no role in study design, data collection and analysis,
   decision to publish, or preparation of the manuscript.
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NR 38
TC 32
Z9 36
U1 0
U2 15
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JAN 17
PY 2013
VL 8
IS 1
AR e54247
DI 10.1371/journal.pone.0054247
PG 13
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 073JI
UT WOS:000313738900057
PM 23349837
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU de Heredia, FP
   Gómez-Martínez, S
   Marcos, A
AF Perez de Heredia, Fatima
   Gomez-Martinez, Sonia
   Marcos, Ascension
TI Obesity, inflammation and the immune system
SO PROCEEDINGS OF THE NUTRITION SOCIETY
LA English
DT Article; Proceedings Paper
CT 5th International Immunonutrition Workshop
CY APR 06-08, 2011
CL Puerto Vallarta, MEXICO
DE Obesity; Inflammation; Immune response; Adipose tissue; Immunonutrition
ID TUMOR-NECROSIS-FACTOR; LOW-GRADE INFLAMMATION; C-REACTIVE PROTEIN;
   ADIPOSE-TISSUE; METABOLIC SYNDROME; ABDOMINAL ADIPOSITY; CARDIOVASCULAR
   RISK; INSULIN-RESISTANCE; PHYSICAL-ACTIVITY; GENE-EXPRESSION
AB Obesity shares with most chronic diseases the presence of an inflammatory component, which accounts for the development of metabolic disease and other associated health alterations. This inflammatory state is reflected in increased circulating levels of pro-inflammatory proteins, and it occurs not only in adults but also in adolescents and children. The chronic inflammatory response has its origin in the links existing between the adipose tissue and the immune system. Obesity, like other states of malnutrition, is known to impair the immune function, altering leucocyte counts as well as cell-mediated immune responses. In addition, evidence has arisen that an altered immune function contributes to the pathogenesis of obesity. This review attempts to briefly comment on the various plausible explanations that have been proposed for the phenomenon: (1) the obesity-associated increase in the production of leptin (pro-inflammatory) and the reduction in adiponectin (anti-inflammatory) seem to affect the activation of immune cells; (2) NEFA can induce inflammation through various mechanisms (such as modulation of adipokine production or activation of Toll-like receptors); (3) nutrient excess and adipocyte expansion trigger endoplasmic reticulum stress; and (4) hypoxia occurring in hypertrophied adipose tissue stimulates the expression of inflammatory genes and activates immune cells. Interestingly, data suggest a greater impact of visceral adipose tissue and central obesity, rather than total body fat, on the inflammatory process. In summary, there is a positive feedback loop between local inflammation in adipose tissue and altered immune response in obesity, both contributing to the development of related metabolic complications.
C1 [Perez de Heredia, Fatima] Inst Food Sci Technol & Nutr, Dept Metab & Nutr, Immunonutr Res Grp, Madrid, Spain.
   Spanish Natl Res Council ICTAN CSIC, Madrid, Spain.
C3 Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Instituto
   de Ciencia y Tecnologia de Alimentos y Nutricion (ICTAN); Consejo
   Superior de Investigaciones Cientificas (CSIC); CSIC - Instituto de
   Ciencia y Tecnologia de Alimentos y Nutricion (ICTAN)
RP de Heredia, FP (corresponding author), Inst Food Sci Technol & Nutr, Dept Metab & Nutr, Immunonutr Res Grp, Madrid, Spain.
EM fatima.perezdeheredia@ictan.csic.es
RI de Heredia, Fatima/L-1241-2019; Sanchez, Ascension/K-4965-2014; Gómez
   Martínez, Sonia/Q-2626-2017
OI Perez de Heredia, Fatima/0000-0002-2537-3327; Gomez_Martinez,
   Sonia/0000-0002-3281-0118
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NR 52
TC 564
Z9 620
U1 0
U2 91
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0029-6651
EI 1475-2719
J9 P NUTR SOC
JI Proc. Nutr. Soc.
PD MAY
PY 2012
VL 71
IS 2
BP 332
EP 338
DI 10.1017/S0029665112000092
PG 7
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Nutrition & Dietetics
GA 939OY
UT WOS:000303823000015
PM 22429824
OA Green Submitted, Bronze
DA 2025-06-11
ER

PT J
AU Tarry-Adkins, JL
   Ozanne, SE
AF Tarry-Adkins, Jane L.
   Ozanne, Susan E.
TI Mechanisms of early life programming: current knowledge and future
   directions
SO AMERICAN JOURNAL OF CLINICAL NUTRITION
LA English
DT Article; Proceedings Paper
CT International Conference on The Power of Programming - Developmental
   Origins of Health and Disease
CY MAY 06-08, 2010
CL Univ Munich Med Ctr, Munich, GERMANY
SP Early Nutr Acad, European Early Nutr Programming Project, Dev Origins Hlth & Dis Soc, Abbott Nutr Hlth Inst/Abbott Nutr, Danone Baby Nutr/Danone Res, Nestle Nutr Inst, Ferrero MSC GmbH & Co KG, S.A. Beneo Orafti, Biovitrum AB, DSM Nutrit Prod Ltd, Fresenius Kabi Deutschland GmbH, Labs Ordesa SL, Life Measurement Inc, Martek Corp
HO Univ Munich Med Ctr
ID INTRAUTERINE GROWTH-RETARDATION; LOW-PROTEIN-DIET; DEPENDENT
   DIABETES-MELLITUS; LOW-BIRTH-WEIGHT; CATCH-UP GROWTH; THRIFTY PHENOTYPE
   HYPOTHESIS; IMPAIRED GLUCOSE-TOLERANCE; MATERNAL IRON RESTRICTION;
   ADOLESCENTS BORN PRETERM; FOR-GESTATIONAL-AGE
AB It has been >20 y since epidemiologic studies showed a relation between patterns of early growth and subsequent risk of diseases, such as type 2 diabetes, cardiovascular disease, and the metabolic syndrome. Studies of identical twins, individuals who were in utero during periods of famine, and animal models have provided strong evidence that the early environment, including early nutrition, plays an important role in mediating these relations. The concept of early life programming is therefore widely accepted. However, the mechanisms by which a phenomenon that occurs in early life can have long-term effects on the function of a cell and therefore on the metabolism of an organism many years later are only starting to emerge. These mechanisms include 1) permanent structural changes in an organ resulting from suboptimal concentrations of an important factor during a critical period of development, eg, the permanent reduction in beta cell mass in the endocrine pancreas; 2) persistent alterations in epigenetic modifications (eg, DNA methylation and histone modifications) that lead to changes in gene expression (eg, several transcription factors are susceptible to programmed changes in gene expression through such mechanisms); and 3) permanent effects on the regulation of cellular aging (eg, increases in oxidative stress that lead to macromolecular damage, including that to DNA and specifically to telomeres, can contribute to such effects). Further understanding of such processes will enable the development of preventive and intervention strategies to combat the burden of common diseases such as type 2 diabetes and cardiovascular disease. Am J Clin Nutr 2011;94(suppl):1765S-71S.
C1 [Ozanne, Susan E.] Univ Cambridge, Addenbrookes Hosp, Inst Metab Sci, Metab Res Labs,Addenbrookes Treatment Ctr, Cambridge CB2 OQQ, England.
C3 University of Cambridge; Cambridge University Hospitals NHS Foundation
   Trust; Addenbrooke's Hospital
RP Ozanne, SE (corresponding author), Univ Cambridge, Addenbrookes Hosp, Inst Metab Sci, Metab Res Labs,Addenbrookes Treatment Ctr, Level 4,Box 289,Hills Rd, Cambridge CB2 OQQ, England.
EM seo10@cam.ac.uk
OI Tarry-Adkins, Jane/0000-0001-9569-6132; Ozanne,
   Susan/0000-0001-8753-5144
FU Biotechnology and Biological Sciences Research Council Funding Source:
   Medline; British Heart Foundation [PG/09/037/27387, FS/09/029/27902]
   Funding Source: Medline; Medical Research Council [G0600717] Funding
   Source: Medline
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NR 89
TC 128
Z9 141
U1 1
U2 20
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0002-9165
EI 1938-3207
J9 AM J CLIN NUTR
JI Am. J. Clin. Nutr.
PD DEC
PY 2011
VL 94
IS 6
BP 1765S
EP 1771S
DI 10.3945/ajcn.110.000620
PG 7
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Nutrition & Dietetics
GA 852PA
UT WOS:000297368700056
PM 21543536
OA Bronze
DA 2025-06-11
ER

PT J
AU Perez-Vizcaino, F
   Duarte, J
   Jimenez, R
   Santos-Buelga, C
   Osuna, A
AF Perez-Vizcaino, Francisco
   Duarte, Juan
   Jimenez, Rosario
   Santos-Buelga, Celestino
   Osuna, Antonio
TI Antihypertensive effects of the flavonoid quercetin
SO PHARMACOLOGICAL REPORTS
LA English
DT Review
DE quercetin; hypertension; flavonoids; nitric oxide; oxidative stress
ID SPONTANEOUSLY HYPERTENSIVE-RATS; CORONARY-HEART-DISEASE; PREVENTS
   ENDOTHELIAL DYSFUNCTION; RANDOMIZED CONTROLLED-TRIAL; VASCULAR
   SMOOTH-MUSCLE; BLOOD-PRESSURE; NITRIC-OXIDE; OXIDATIVE STATUS; RISK;
   ANTIOXIDANT
AB The blood pressure lowering effect of a fruit and vegetable-rich diet is a necessary dietary lifestyle measure now included the guidelines for the management of arterial hypertension. Furthermore, flavonoids represent a major class of plant polyphenolics. The present review addresses the antihypertensive effect of quercetin, one of the most abundant flavonoids present in fruits and vegetables, and probably the best studied flavonoid because of its high biological activity. Quercetin has been shown to induce a progressive, dose-dependent and sustained reduction in blood pressure when given chronically in several rat models of hypertension, including spontaneously hypertensive rats, L-NAME-treated rats, DOCA-salt hypertensive rats, two-kidney one-clip Goldblatt rats, rats with aortic constriction and Dahl salt-sensitive hypertensive rats. Quercetin was also effective in reducing blood pressure in rat models of metabolic syndrome, including the obese Zucker rats as well as rats treated with a high-sucrose, high-fat diet. Quercetin also prevented morphological and functional changes in the heart, vessels and kidney, while increasing production of reactive oxygen species associated with hypertension. A high dose of quercetin also reduced blood pressure in stage I hypertensive patients in a randomized, double-blind, placebo-controlled, crossover study. Since raised blood pressure is the major cause of stroke as well as an important risk factor for ischemic heart disease, we propose that the blood pressure-lowering effect of quercetin could be an important mechanism contributing to the reduced risk of myocardial infarction and stroke observed with fruit and vegetables-rich diets, and possibly with flavonoid-rich diets.
C1 [Perez-Vizcaino, Francisco] Univ Complutense Madrid, Sch Med, Dept Pharmacol, E-28040 Madrid, Spain.
   [Duarte, Juan; Jimenez, Rosario] Univ Granada, Dept Pharmacol, Sch Pharm, E-18071 Granada, Spain.
   [Santos-Buelga, Celestino] Univ Salamanca, Nutr & Food Sci Unit, Sch Pharm, E-37007 Salamanca, Spain.
   [Osuna, Antonio] Hosp Virgen Nieves, Serv Nephrol, Expt Unit, Granada 18012, Spain.
C3 Complutense University of Madrid; University of Granada; University of
   Salamanca; Hospital Universitario Virgen de las Nieves
RP Perez-Vizcaino, F (corresponding author), Univ Complutense Madrid, Sch Med, Dept Pharmacol, E-28040 Madrid, Spain.
EM fperez@med.ucm.es
RI Duarte, Juan/AAH-1574-2020; Osuna, Antonio/H-1896-2015; Perez-Vizcaino,
   Francisco/A-9735-2011; Santos-Buelga, Celestino/A-1071-2008; Duarte,
   Juan/K-6472-2014; JIMENEZ, ROSARIO/K-9701-2014
OI Perez-Vizcaino, Francisco/0000-0001-6309-7418; Santos-Buelga,
   Celestino/0000-0001-6592-5299; Duarte, Juan/0000-0002-9153-5857;
   JIMENEZ, ROSARIO/0000-0003-3872-2669
FU Comision Interministerial de Ciencia y Tecnologia (CICYT)
   [AGL2007-66108]; CICYT [SAF2005-03770, SAF 2008-03948]; Junta de
   Andalucia, Proyecto de Excelencia [P06-CTS-01555]; Ministerio de Ciencia
   a Innovacion, Instituto de Salud Carlos III [RD06/0009]; Junta de
   Castilla y Leon [SA003A07]; Consortium FUN-C-FOOD [CSD2007-00063];
   Consolider-Ingenio 2010 Programme
FX This research is supported by a joint Grant from Comision
   Interministerial de Ciencia y Tecnologia (CICYT) AGL2007-66108.
   Financial support was also obtained by CICYT grants (SAF2005-03770 and
   SAF 2008-03948 to F.P.V), from Junta de Andalucia, Proyecto de
   Excelencia (P06-CTS-01555) and by the Ministerio de Ciencia a
   Innovacion, Instituto de Salud Carlos III (Red HERACLES RD06/0009) to
   J.D., from Junta de Castilla y Leon (SA003A07) and through the
   Consortium FUN-C-FOOD (CSD2007-00063) funded by the Consolider-Ingenio
   2010 Programme to C.S-B.
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NR 48
TC 229
Z9 251
U1 0
U2 66
PU POLISH ACAD SCIENCES INST PHARMACOLOGY
PI KRAKOW
PA SMETNA 12, 31-343 KRAKOW, POLAND
SN 1734-1140
J9 PHARMACOL REP
JI Pharmacol. Rep.
PD JAN-FEB
PY 2009
VL 61
IS 1
BP 67
EP 75
DI 10.1016/S1734-1140(09)70008-8
PG 9
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 440BF
UT WOS:000265672200008
PM 19307694
DA 2025-06-11
ER

PT J
AU Jiménez-Ortega, RF
   Meneses-León, J
   Hernández, S
   Thebar-Moreno, P
   Aparicio-Bautista, DI
   Becerra-Cervera, A
   Aguilar-Salinas, C
   Salmerón, J
   Rivera-Paredez, B
   Velázquez-Cruz, R
AF Jimenez-Ortega, Rogelio F.
   Meneses-Leon, Joacim
   Hernandez, Sonia
   Thebar-Moreno, Priscila
   Aparicio-Bautista, Diana I.
   Becerra-Cervera, Adriana
   Aguilar-Salinas, Carlos
   Salmeron, Jorge
   Rivera-Paredez, Berenice
   Velazquez-Cruz, Rafael
TI High dietary antioxidant index associated with reduced insulin
   resistance in female Mexican children and adolescents
SO NUTRITION RESEARCH
LA English
DT Article
DE Dietary antioxidant index; Insulin resistance; Mexican children; Mexican
   adolescents; Obesity; Cross-sectional analysis; Overweight
ID ACTIVATED SIGNALING PATHWAYS; OXIDATIVE STRESS; VITAMIN-C; SUBCLINICAL
   INFLAMMATION; METABOLIC SYNDROME; DIABETES-MELLITUS; OBESE CHILDREN;
   FREE-RADICALS; PLASMA; RISK
AB Antioxidant intake is inversely associated with different health outcomes; however, its association with insulin resistance (IR) has not been well documented. We hypothesized that the Dietary Antioxidant Index (DAI) is inversely associated with IR in Mexican children and adolescents. A cross-sectional analysis was performed using data from the Health Workers Cohort Study. A total of 830 children and adolescents aged 7 to 18 years were enrolled. The DAI was evaluated in three categories defined by tertiles using a semiquantitative food frequency questionnaire. IR was defined using previously reported cutoff points in the homeostasis model assessment. This association was evaluated using a multiple logistic regression model. Stratified analysis was performed using body mass index and sex. The prevalence of IR based on the DAI categories (low, medium, high) was 23.8%, 24.2%, and 15.3%, respectively. The IR odds ratio (OR) for participants in the highest DAI category was 0.49 (95% confidence interval [CI]: 0.30-0.80). Notably, female Children and Adolescents in the highest DAI category had significantly lower odds of developing IR than those in the lowest DAI category (OR 0.54, 95% CI 0.29-0.98). Participants with overweight/obesity showed a similar association (OR 0.37, 95% CI 0.18-0.76). These results suggest that the DAI is inversely associated with IR, particularly in females, highlighting the potential role of antioxidants in preventing IR. This underscores the need to establish recommendations for antioxidant consumption in female children and adolescents.
C1 [Aparicio-Bautista, Diana I.; Becerra-Cervera, Adriana; Velazquez-Cruz, Rafael] Inst Nacl Med Genom INMEGEN, Lab Genom Metab Oseo, Mexico City, Mexico.
   [Jimenez-Ortega, Rogelio F.] Univ Estatal Valle Ecatepec, Ecatepec De Morelos, Estado de Mexic, Mexico.
   [Meneses-Leon, Joacim; Hernandez, Sonia; Thebar-Moreno, Priscila; Salmeron, Jorge; Rivera-Paredez, Berenice] Univ Nacl Autonoma Mexico, Salud Fac Med, Ctr Invest Polit Poblac, Mexico City, Mexico.
   [Becerra-Cervera, Adriana] Consejo Nacl Human Ciencias & Tecnol CONAHCYT, Mexico City, Mexico.
   [Aguilar-Salinas, Carlos] Tecnol Monterrey, Escuela Med & Ciencias Salud, Mexico City, Mexico.
   [Aguilar-Salinas, Carlos] Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Unidad Invest Enfermedades Metab, Mexico City, Mexico.
C3 Instituto Nacional de Medicina Genomica; Universidad Nacional Autonoma
   de Mexico; Tecnologico de Monterrey; Instituto Nacional de Ciencias
   Medicas y Nutricion Salvador Zubiran - Mexico
RP Velázquez-Cruz, R (corresponding author), Inst Nacl Med Genom INMEGEN, Lab Genom Metab Oseo, Mexico City, Mexico.
RI Jiménez-Ortega, Rogelio/AGF-9270-2022; APARICIO, DIANA/JRW-9922-2023;
   Aguilar Salinas, Carlos A/JFS-8212-2023; Rivera-Paredez,
   Berenice/AAF-5745-2020; Velazquez-Cruz, Rafael/AAC-3710-2021
OI Velazquez-Cruz, Rafael/0000-0003-4515-0777; Becerra-Cervera,
   Adriana/0000-0002-9727-6665
FU Consejo Nacional de Ciencia y Tecnologia [7876, 87783, 262233, 26267M,
   SALUD-2010-01-139796, SALUD-2011-01-161930, CB-2013-01-221628,
   CF-2019-102962]; Consejo Nacional de Ciencia y Tecnologa [CF
   2019-102962]; Consejo Nacional de Humanidades, Ciencia y Tecnologia
   (CONAHCYT) [CVU 508876]; INMEGEN [346-05/2018/I, 399-07/2019/I]; The
   "Financiamiento de Proyectos de Investigacion para la Salud" (FPIS) 2023
   [FPIS2023-INMEGEN-5251]
FX The Health Workers Cohort Study was supported by: Consejo Nacional de
   Ciencia y Tecnologia (Grant numbers: 7876, 87783, 262233, 26267M,
   SALUD-2010-01-139796, SALUD-2011-01-161930, and CB-2013-01-221628,
   CF-2019-102962) . R.F.J.-O. is supported by a Postdoctoral Fellowship
   from the Consejo Nacional de Ciencia y Tecnologia (Grant Ciencia de
   Frontera CF 2019-102962) . A.B.-C. is supported by a Postdoctoral
   Fel-lowship from the Consejo Nacional de Humanidades, Ciencia y
   Tecnologia (CONAHCYT-Estancia Posdoctoral de Incidencia Inicial 2022
   with CVU 508876) . R.V.-C. was partially supported by the
   "Financiamiento de Proyectos de Investigacion para la Salud" (FPIS)
   2023, Proyecto FPIS2023-INMEGEN-5251; and by INMEGEN (346-05/2018/I and
   399-07/2019/I) .
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NR 65
TC 0
Z9 0
U1 1
U2 3
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0271-5317
EI 1879-0739
J9 NUTR RES
JI Nutr. Res.
PD DEC
PY 2024
VL 132
BP 53
EP 66
DI 10.1016/j.nutres.2024.09.016
EA OCT 2024
PG 14
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA K7K4B
UT WOS:001345623600001
PM 39461300
DA 2025-06-11
ER

PT J
AU Ziyaei, K
   Abdi, F
   Mokhtari, M
   Daneshmehr, MA
   Ataie, Z
AF Ziyaei, Kobra
   Abdi, Fatemeh
   Mokhtari, Majid
   Daneshmehr, Mohammad Ali
   Ataie, Zahra
TI Phycocyanin as a nature-inspired antidiabetic agent: A systematic review
SO PHYTOMEDICINE
LA English
DT Review
DE Diabetes; Spirulina; Phycocyanin; Insulin; Molecular mechanism;
   Nutraceutical
ID PANCREATIC BETA-CELLS; SPIRULINA-PLATENSIS; OXIDATIVE STRESS;
   INHIBITORY-ACTIVITIES; DIABETIC-NEPHROPATHY; UP-REGULATION; APOPTOSIS;
   GLUCOSE; ANTIOXIDANT; ACTIVATION
AB Background: Nutraceuticals have been important for more than two decades for their safety, efficacy, and outstanding effects. Diabetes is a major metabolic syndrome, which may be improved using nutritional pharmaceuticals. Some microalgae species, such as spirulina, stand out by providing biomass with exceptional nutritional properties. Spirulina has a wide range of pharmacological effects, mostly related to phycocyanin. Phycocyanin is a protein compound with antidiabetic properties, known as a nutraceutical. Objective: This review delves into phycocyanin applications in diabetes and its complications and ascertains the mechanisms involved. Methods: Scopus, PubMed, Cochrane Library, Web of Science, and ProQuest databases were systematically reviewed (up to April 30, 2023), in which only animal and cellular studies were found. Results: According to animal studies, the administration of phycocyanin affected biochemical parameters (primary outcome) related to diabetes. These results showed an increase in fasting insulin serum and a decrease in fasting blood glucose, glycosylated serum protein, and glycosylated hemoglobin. In cellular studies, though, phycocyanin prevented methylglyoxal and human islet amyloid polypeptide-induced dysfunction in beta-cells and induced apoptosis through different molecular pathways (secondary outcome), including activation of Nrf2, PI3K/Akt, and suppression of JNK and p38. Also, phycocyanin exerted its antidiabetic effect by affecting the pathways regulating hepatic glucose metabolism. Conclusions: Thus, based on the available information and literature, targeting these pathways by phycocyanin may unleash an array of benefits, including positive outcomes of the antidiabetic effects of phycocyanin as a nutraceutical. Other: This systematic review was registered in the International Prospective Register of Systematic Reviews (PROSPERO) at the National Institute of Health. The registration number is CRD42022307522.
C1 [Ziyaei, Kobra] Univ Tehran, Fac Nat Resources, Dept Fisheries, Karaj, Iran.
   [Abdi, Fatemeh] Alborz Univ Med Sci, Noncommunicable Dis Res Ctr, Karaj, Iran.
   [Mokhtari, Majid] Univ Tehran, Dept Mechatron, Kish Int Campus, Kish Isl, Iran.
   [Mokhtari, Majid] Natl Inst Genet Engn & Biotechnol, Dept Bioinformat, Tehran, Iran.
   [Daneshmehr, Mohammad Ali] Iran Univ Med Sci, Sch Pharm, Dept Med Chem, Tehran, Iran.
   [Ataie, Zahra] Alborz Univ Med Sci, Evidence Based Phytotherapy & Complementary Med R, Karaj, Iran.
   [Ataie, Zahra] Alborz Univ Med Sci, Fac Pharm, Dept Pharmaceut, Karaj, Iran.
   [Ataie, Zahra] Alborz Univ Med Sci, Fac Pharm, Pharmaceut, Karaj, Iran.
C3 University of Tehran; Alborz University of Medical Sciences; Iran
   University of Medical Sciences; Alborz University of Medical Sciences;
   Alborz University of Medical Sciences; Alborz University of Medical
   Sciences
RP Ataie, Z (corresponding author), Alborz Univ Med Sci, Fac Pharm, Pharmaceut, Karaj, Iran.
EM zataie@abzums.ac.ir
RI Mokhtari, Majid/KSL-7261-2024; Daneshmehr, Mohammad/AAM-9794-2021; Abdi,
   Fatemeh/KHX-1805-2024; ataie, zahra/AAF-1127-2021; Ataie,
   Zahra/S-4829-2017
OI Ziyaei, Kobra/0009-0008-7171-7646; Mokhtari, Ph.D.,
   Majid/0000-0002-0927-6420; Ataie, Zahra/0000-0002-7579-9457
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NR 78
TC 22
Z9 22
U1 7
U2 35
PU ELSEVIER GMBH
PI MUNICH
PA HACKERBRUCKE 6, 80335 MUNICH, GERMANY
SN 0944-7113
EI 1618-095X
J9 PHYTOMEDICINE
JI Phytomedicine
PD OCT
PY 2023
VL 119
AR 154964
DI 10.1016/j.phymed.2023.154964
EA AUG 2023
PG 11
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA P7PB8
UT WOS:001052545900001
PM 37544212
DA 2025-06-11
ER

PT J
AU Zhao, MD
   Yin, GH
   Xu, J
   Ge, XY
   Li, A
   Mei, YY
   Wu, JT
   Liu, XL
   Wei, LP
   Xu, Q
AF Zhao, Meiduo
   Yin, Guohuan
   Xu, Jing
   Ge, Xiaoyu
   Li, Ang
   Mei, Yayuan
   Wu, Jingtao
   Liu, Xiaolin
   Wei, Lanping
   Xu, Qun
TI Independent, combine and interactive effects of heavy metal exposure on
   dyslipidemia biomarkers: A cross-sectional study in northeastern China
SO ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
LA English
DT Article
DE Heavy metal; Dyslipidemia; Interaction; BKMR; Marginal effect
ID METABOLIC SYNDROME; CADMIUM EXPOSURE; OXIDATIVE STRESS; NATIONAL-HEALTH;
   BLOOD; CHROMIUM; LEAD; URINE; ASSOCIATIONS; IMPAIRMENT
AB Dyslipidemia is a common disease in the older population and represents a considerable disease burden worldwide. Epidemiological and experimental studies have indicated associations between heavy metal exposure and dyslipidemia; few studies have investigated the effects of heavy metal mixture and interactions between metals on dyslipidemia. We recruited 1121 participants living in heavy metal-contaminated and control areas in northeast China from a cross-sectional survey (2017-2019). Urinary metals including chromium (Cr), cadmium (Cd), lead (Pb), and manganese (Mn) and dyslipidemia biomarkers, namely triglycerides (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) levels, were measured. The generalized linear model (GLM) was used to explore the association of a single metal with dyslipidemia biomarkers. Bayesian kernel machine regression (BKMR) and multivariable linear regression were performed to explore the overall effect of metal mixture and the interaction between metals on dyslipidemia. Heavy metal mixture was positively associated with LDL-C, TC, and TG and negatively with HDL-C. In multivariable linear regression, Pb and Cd exhibited a synergistic association with LDL-C in the participants without hyperlipemia. Mn-Cd and Pb-Cr also showed a synergistic association with increasing the level of LDL-C in subjects without hyperlipemia. Cd-Cr showed an antagonistic association with HDL-C, respectively. Cr-Mn exhibited an antagonistic association with decreased HDL-C and TG levels. No significant interaction was noted among the three metals. Our study indicated that exposure to heavy metals is associated with dyslipidemia biomarkers and the presence of potential synergistic or antagonistic interactions between the heavy metals.
C1 [Zhao, Meiduo; Yin, Guohuan; Xu, Jing; Ge, Xiaoyu; Li, Ang; Mei, Yayuan; Wu, Jingtao; Xu, Qun] Chinese Acad Med Sci, Peking Union Med Coll, Dept Epidemiol & Biostat, Inst Basic Med Sci,Sch Basic Med, Beijing 100005, Peoples R China.
   [Zhao, Meiduo; Xu, Jing; Ge, Xiaoyu; Li, Ang; Mei, Yayuan; Wu, Jingtao; Xu, Qun] Chinese Acad Med Sci & Peking Union Med Coll, Ctr Environm & Hlth Sci, Beijing 100005, Peoples R China.
   [Liu, Xiaolin] Jinzhou Med Univ, Dept Epidemiol & Biostat, Jinzhou 121001, Liaoning, Peoples R China.
   [Wei, Lanping] Jinzhou Cent Hosp, Jinzhou 121001, Liaoning, Peoples R China.
C3 Institute of Basic Medical Sciences - CAMS; Chinese Academy of Medical
   Sciences - Peking Union Medical College; Peking Union Medical College;
   Chinese Academy of Medical Sciences - Peking Union Medical College;
   Peking Union Medical College; Jinzhou Medical University
RP Xu, Q (corresponding author), Chinese Acad Med Sci, Peking Union Med Coll, Dept Epidemiol & Biostat, Inst Basic Med Sci,Sch Basic Med, Beijing 100005, Peoples R China.
EM xuqun@ibms.cams.cn
RI yin, guohuan/KMA-6955-2024; Xu, Jing/GXN-0678-2022
OI Li, Ang/0000-0002-4439-7834
FU Non-profit Central Research Institute Fund of Chinese Academy of Medical
   Sciences [2022-JKCS- 11]; Chinese Academy of Medical Sciences (CAMS)
   Innovation Fund for Medical Sciences [2022-I2M-JB-003]
FX Funding This research was supported by the Non-profit Central Research
   Institute Fund of Chinese Academy of Medical Sciences (No. 2022-JKCS-
   11) and Chinese Academy of Medical Sciences (CAMS) Innovation Fund for
   Medical Sciences (No. 2022-I2M-JB-003) . These funding source supported
   the implementation of field surveys and data collection.
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NR 81
TC 25
Z9 28
U1 3
U2 32
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0147-6513
EI 1090-2414
J9 ECOTOX ENVIRON SAFE
JI Ecotox. Environ. Safe.
PD JAN 15
PY 2023
VL 250
AR 114494
DI 10.1016/j.ecoenv.2022.114494
EA JAN 2023
PG 12
WC Environmental Sciences; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Toxicology
GA 8A5WM
UT WOS:000916309300001
PM 36608569
OA gold
DA 2025-06-11
ER

PT J
AU Chua, D
   Low, ZS
   Cheam, GX
   Ng, AS
   Tan, NS
AF Chua, Damien
   Low, Zun Siong
   Cheam, Guo Xiang
   Ng, Aik Seng
   Tan, Nguan Soon
TI Utility of Human Relevant Preclinical Animal Models in Navigating NAFLD
   to MAFLD Paradigm
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE nonalcoholic fatty liver disease (NAFLD); nonalcoholic steatohepatitis
   (NASH); metabolic dysregulation-associated fatty liver disease (MAFLD);
   hepatic fibrosis; hepatocellular carcinoma (HCC); cardiovascular disease
   (CVD); preclinical models; diet-induced obesogenic model; genetic
   models; chemically induced model
ID NONALCOHOLIC FATTY LIVER; ENDOPLASMIC-RETICULUM STRESS;
   CHOLINE-DEFICIENT DIET; INTESTINAL BACTERIAL OVERGROWTH; HEPATIC
   INSULIN-RESISTANCE; UNFOLDED PROTEIN RESPONSE; CHRONIC KIDNEY-DISEASE;
   NECROSIS-FACTOR-ALPHA; RAT MODEL; METABOLIC SYNDROME
AB Fatty liver disease is an emerging contributor to disease burden worldwide. The past decades of work established the heterogeneous nature of non-alcoholic fatty liver disease (NAFLD) etiology and systemic contributions to the pathogenesis of the disease. This called for the proposal of a redefinition in 2020 to that of metabolic dysfunction-associated fatty liver disease (MAFLD) to better reflect the current understanding of the disease. To date, several clinical cohort studies comparing NAFLD and MAFLD hint at the relevancy of the new nomenclature in enriching for patients with more severe hepatic injury and extrahepatic comorbidities. However, the underlying systemic pathogenesis is still not fully understood. Preclinical animal models have been imperative in elucidating key biological mechanisms in various contexts, including intrahepatic disease progression, interorgan crosstalk and systemic dysregulation. Furthermore, they are integral in developing novel therapeutics against MAFLD. However, substantial contextual variabilities exist across different models due to the lack of standardization in several aspects. As such, it is crucial to understand the strengths and weaknesses of existing models to better align them to the human condition. In this review, we consolidate the implications arising from the change in nomenclature and summarize MAFLD pathogenesis. Subsequently, we provide an updated evaluation of existing MAFLD preclinical models in alignment with the new definitions and perspectives to improve their translational relevance.
C1 [Chua, Damien; Low, Zun Siong; Tan, Nguan Soon] Nanyang Technol Univ Singapore, Lee Kong Chian Sch Med, 11 Mandalay Rd, Singapore 308232, Singapore.
   [Cheam, Guo Xiang; Tan, Nguan Soon] Nanyang Technol Univ Singapore, Sch Biol Sci, 60 Nanyang Dr, Singapore 637551, Singapore.
   [Ng, Aik Seng] Univ Oxford, John Radcliffe Hosp, Radcliffe Dept Med, Oxford OX3 9DU, England.
C3 Nanyang Technological University; Nanyang Technological University;
   University of Oxford
RP Chua, D; Tan, NS (corresponding author), Nanyang Technol Univ Singapore, Lee Kong Chian Sch Med, 11 Mandalay Rd, Singapore 308232, Singapore.; Tan, NS (corresponding author), Nanyang Technol Univ Singapore, Sch Biol Sci, 60 Nanyang Dr, Singapore 637551, Singapore.
EM damien001@e.ntu.edu.sg; nstan@ntu.edu.sg
RI ; Tan, Nguan Soon/A-2220-2011
OI Guoxiang, Cheam/0000-0002-1702-6616; Chua, Damien/0000-0003-0007-1688;
   Tan, Nguan Soon/0000-0003-0136-7341; Low, Zun Siong/0000-0001-5335-6826;
   Ng, Aik Seng/0000-0003-1925-4759
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NR 372
TC 11
Z9 12
U1 2
U2 19
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD DEC
PY 2022
VL 23
IS 23
AR 14762
DI 10.3390/ijms232314762
PG 47
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 6X4UW
UT WOS:000896411100001
PM 36499091
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Quirós-Fernández, R
   López-Plaza, B
   Bermejo, LM
   Milla, SP
   Zangara, A
   Candela, CG
AF Quiros-Fernandez, Rebeca
   Lopez-Plaza, Bricia
   Bermejo, Laura M.
   Palma Milla, Samara
   Zangara, Andrea
   Candela, Carmen Gomez
TI Oral Supplement Containing Hydroxytyrosol and Punicalagin Improves
   Dyslipidemia in an Adult Population without Co-Adjuvant Treatment: A
   Randomized, Double-Blind, Controlled and Crossover Trial
SO NUTRIENTS
LA English
DT Article
DE cardiovascular disease; atherosclerosis; hydroxytyrosol; punicalagin;
   dyslipidemia; total cholesterol; low-density lipoprotein cholesterol;
   high-density lipoprotein cholesterol; triglycerides
ID LOW-DENSITY-LIPOPROTEIN; CARDIOVASCULAR RISK-FACTORS; CIRCULATING
   OXIDIZED LDL; ENDOTHELIAL DYSFUNCTION; OLIVE OIL; METABOLIC SYNDROME;
   POMEGRANATE FRUIT; OXIDATIVE STRESS; LIPID-METABOLISM; DISEASE
AB Hydroxytyrosol (HT) and punicalagin (PC) exert cardioprotective and antiatherosclerotic effects. This study evaluated the effect of an oral supplement containing HT and PC (SAx) on dyslipidemia in an adult population. A randomized, double-blind, controlled, crossover trial was conducted over a 20-week period. SAx significantly reduced the plasma levels of triglycerides (TG) in subjects with hypertriglyceridemia (>= 150 mg/dL) (from 200.67 +/- 51.38 to 155.33 +/- 42.44 mg/dL; p < 0.05), while no such effects were observed in these subjects after the placebo. SAx also significantly decreased the plasma levels of low-density lipoprotein cholesterol (LDL-C) in subjects with high plasma levels of LDL-C (>= 160 mg/dL) (from 179.13 +/- 16.18 to 162.93 +/- 27.05 mg/dL; p < 0.01), while no such positive effect was observed with the placebo. In addition, the placebo significantly reduced the plasma levels of high-density lipoprotein cholesterol (HDL-C) in the total population (from 64.49 +/- 12.65 to 62.55 +/- 11.57 mg/dL; p < 0.05), while SAx significantly increased the plasma levels of HDL-C in subjects with low plasma levels of HDL-C (<50 mg/dL) (from 44.25 +/- 3.99 to 48.00 +/- 7.27 mg/dL; p < 0.05). In conclusion, the supplement containing HT and PC exerted antiatherosclerotic and cardio-protective effects by considerably improving dyslipidemia in an adult population, without co-adjuvant treatment or adverse effects.
C1 [Quiros-Fernandez, Rebeca; Lopez-Plaza, Bricia; Bermejo, Laura M.] Hosp La Paz Inst Hlth Res IdiPAZ, Nutr Res Grp, Madrid 28046, Spain.
   [Palma Milla, Samara; Candela, Carmen Gomez] Hosp Univ La Paz, Nutr Dept, Madrid 28046, Spain.
   [Zangara, Andrea] Swinburne Univ, Ctr Human Psychopharmacol, Melbourne, Vic 3122, Australia.
   [Zangara, Andrea] Euromed SA, C Rec Dalt 21-23, Mollet Del Valles 08100, Spain.
C3 Hospital Universitario La Paz; Swinburne University of Technology
RP Quirós-Fernández, R; López-Plaza, B (corresponding author), Hosp La Paz Inst Hlth Res IdiPAZ, Nutr Res Grp, Madrid 28046, Spain.
EM rquirosfernandez@gmail.com; bricia.plaza@idipaz.es; mlbermej@ucm.es;
   samara.palma@salud.madrid.org; azangara@euromed.es;
   cgcandela@salud.madrid.org
RI LOPEZ PLAZA, BRICIA/MBW-0717-2025; Bermejo, Laura M/HKF-3325-2023
OI Palma Milla, Samara/0000-0002-0187-1495; Zangara,
   Andrea/0000-0002-1185-6854; Bermejo, Laura M/0000-0001-6826-0181; LOPEZ
   PLAZA, BRICIA/0000-0001-9310-1545
FU Euromed S.A. group through the HENUFOOD project [CEN-20101016]; CENIT
   program of Economy and Competitiveness Ministry 481 of Spain (MINECO);
   University Hospital La Paz
FX The present clinical trial was supported by the Euromed S.A. group
   through the HENUFOOD project (CEN-20101016) from the CENIT program of
   Economy and Competitiveness Ministry 481 of Spain (MINECO) and the
   University Hospital La Paz.
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NR 101
TC 11
Z9 11
U1 1
U2 13
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD MAY
PY 2022
VL 14
IS 9
AR 1879
DI 10.3390/nu14091879
PG 17
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 1F5XN
UT WOS:000795241900001
PM 35565844
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Han, W
   Bai, XJ
   Han, LL
   Sun, XF
   Chen, XM
AF Han, Wen
   Bai, Xiaojuan
   Han, Lulu
   Sun, Xuefeng
   Chen, Xiangmei
TI Association between higher serum uric acid levels within the normal
   physiological range and changes of lumbar spine bone mineral density in
   healthy Chinese postmenopausal women: a longitudinal follow-up study
SO MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY
LA English
DT Article
DE Bone mineral density; Longitudinal; Postmenopausal women; Serum uric
   acid
ID OXIDATIVE STRESS; ALZHEIMERS-DISEASE; METABOLIC SYNDROME; POPULATION;
   RISK; GOUT
AB Objectives: The aim of this study was to investigate whether higher serum uric acid (SUA) levels within the physiological range were associated with changes in lumbar spine bone mineral density (LBMD) in postmenopausal women without existing lumbar spine osteoporosis after a longitudinal follow-up of 3.09 years, and to further confirm the relationship between SUA and bone mineral density (BMD) in other sites such as femoral neck, total hip, and trochanter at follow-up. Methods: A longitudinal study of 175 healthy postmenopausal women without osteoporosis was conducted in Shenyang, China. BMD of the lumbar spine, femoral neck, total hip, and trochanter were measured using dual-energy x-ray absorptiometry at each visit. Pearson's correlation analysis and regression analyses were performed to determine any associations. Results: There were positive correlations between baseline SUA and BMD of the lumbar spine (P = 0.03), total hip (P = 0.04), and trochanter (P = 0.04). Moreover, higher baseline SUA levels were independently associated with LBMD decline and the odds ratio of the baseline SUA of the third quartile group was 0.12 (95% confidence interval, 0.02-0.70, P < 0.05), with P = 0.23 for the trend in baseline SUA when compared with participants in the lowest, first quartile group after adjustment for many potential confounding variables. Conclusions: Higher SUA levels within the normal physiological range were independently associated with decreased LBMD, and SUA levels were positively related to the BMD of the lumbar spine, total hip, and trochanter in healthy Chinese postmenopausal women.
C1 [Han, Wen; Bai, Xiaojuan; Han, Lulu] China Med Univ, Dept Gerontol & Geriatr, Shengjing Hosp, Shenyang 110004, Liaoning, Peoples R China.
   [Sun, Xuefeng; Chen, Xiangmei] Gen Hosp Chinese Peoples Liberat Army, Dept Kidney, Beijing, Peoples R China.
C3 China Medical University
RP Bai, XJ (corresponding author), China Med Univ, Dept Gerontol & Geriatr, Shengjing Hosp, Shenyang 110004, Liaoning, Peoples R China.
EM xiaojuan.bai@163.com
FU National Basic Research Program of China (973 Program) [2013CB530804];
   345 Talent Project [M0698]
FX This work was supported by the National Basic Research Program of China
   (973 Program #2013CB530804) and 345 Talent Project (#M0698).
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NR 43
TC 3
Z9 4
U1 1
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1072-3714
EI 1530-0374
J9 MENOPAUSE
JI Menopause-J. N. Am. Menopause Soc.
PD OCT
PY 2021
VL 28
IS 10
BP 1157
EP 1165
DI 10.1097/GME.0000000000001821
PG 9
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA UZ5HX
UT WOS:000702237200013
PM 34342286
DA 2025-06-11
ER

PT J
AU Hajizadeh-Sharafabad, F
   Zahabi, ES
   Malekahmadi, M
   Zarrin, R
   Alizadeh, M
AF Hajizadeh-Sharafabad, Fatemeh
   Zahabi, Elham Sharifi
   Malekahmadi, Mahsa
   Zarrin, Rasoul
   Alizadeh, Mohammad
TI Carotenoids supplementation and inflammation: a systematic review and
   meta-analysis of randomized clinical trials
SO CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
LA English
DT Review
DE Carotenoids; inflammatory biomarkers; CRP; IL-6; TNF-&#945
ID C-REACTIVE PROTEIN; CORONARY-HEART-DISEASE; OXIDATIVE STRESS;
   CARDIOVASCULAR-DISEASE; SERUM CAROTENOIDS; RISK-FACTORS; LYCOPENE
   SUPPLEMENTATION; METABOLIC SYNDROME; SAFETY EVALUATION; ASTAXANTHIN
AB The aim of this study was to perform a systematic review and meta-analysis on randomized controlled trials investigating the effects of carotenoids on selected inflammatory parameters. PubMed, SCOPUS, and Web of science were searched from inception until April 2021. The random-effect model was used to analyze data and the overall effect size was computed as weighted mean difference (WMD) and corresponding 95% of confidence interval (CI). A total of 26 trials with 35 effect sizes were included in this meta-analysis. The results indicated significant effects of carotenoids on C-reactive protein (CRP) (WMD: -0.54 mg/L, 95% CI: -0.71, -0.37, P < 0.001), and interleukin-6 (IL-6) (WMD: -0.54 pg/mL, 95% CI: -1.01, -0.06, P = 0.025), however the effect on tumor necrosis factor-alpha (TNF-alpha) was not significant (WMD: -0.97 pg/ml, 95% CI: -1.98, 0.03, P = 0.0.059). For the individual carotenoids, astaxanthin, (WMD: -0.30 mg/L, 95% CI: -0.51, -0.09, P = 0.005), lutein/zeaxanthin (WMD: -0.30 mg/L, 95% CI: -0.45, -0.15, P < 0.001), and beta-cryptoxanthin (WMD: -0.35 mg/L, 95% CI: -0.54, -0.15, P < 0.001) significantly decreased CRP level. Also, only lycopene (WMD: -1.08 pg/ml, 95%CI: -2.03, -0.12, P = 0.027) led to a significant decrease in IL-6. The overall results supported possible protective effects of carotenoids on inflammatory biomarkers.
C1 [Hajizadeh-Sharafabad, Fatemeh] Tabriz Univ Med Sci, Fac Nutr & Food Sci, Student Res Comm, Tabriz, Iran.
   [Hajizadeh-Sharafabad, Fatemeh] Tabriz Univ Med Sci, Fac Nutr & Food Sci, Nutr Res Ctr, Dept Clin Nutr, Tabriz, Iran.
   [Zahabi, Elham Sharifi] Iran Univ Med Sci, Sch Publ Hlth, Dept Nutr, Tehran, Iran.
   [Malekahmadi, Mahsa] Mashhad Univ Med Sci, Fac Med, Nutr Dept, Mashhad, Razavi Khorasan, Iran.
   [Zarrin, Rasoul] Urmia Univ Med Sci, Sch Med, Dept Nutr, Orumiyeh, Iran.
   [Alizadeh, Mohammad] Tabriz Univ Med Sci, Fac Nutr & Food Sci, Nutr Res Ctr, Tabriz, Iran.
C3 Tabriz University of Medical Science; Tabriz University of Medical
   Science; Iran University of Medical Sciences; Mashhad University of
   Medical Sciences; Urmia University of Medical Sciences; Tabriz
   University of Medical Science
RP Zarrin, R (corresponding author), Urmia Univ Med Sci, Sch Med, Dept Nutr, Orumiyeh, Iran.; Alizadeh, M (corresponding author), Tabriz Univ Med Sci, Fac Nutr & Food Sci, Dept Clin Nutr, Tabriz, Iran.
EM rasoul.zarrin@uqconnect.edu.au; mdalizadeh@tbzmed.ac.ir
RI Alizadeh, Mohammad/M-4703-2017; malekahmadi, mahsa/ABD-2352-2020;
   Hajizadeh, Fatemeh/HPC-8746-2023
OI Hajizadeh-Sharafabad, Fatemeh/0000-0003-1959-5705; KIM, Dong
   Joo/0000-0001-6373-5803; Malekahmadi, Mahsa/0000-0002-6707-6929
FU Vice-Chancellor for Research at the Student Research Committee, Tabriz
   University of Medical Sciences, Tabriz, Iran. [67755]
FX This study was funded by Vice-Chancellor for Research at the Student
   Research Committee, Tabriz University of Medical Sciences, Tabriz,
   Iran., Grant agreement no. 67755.
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NR 83
TC 42
Z9 43
U1 5
U2 39
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1040-8398
EI 1549-7852
J9 CRIT REV FOOD SCI
JI Crit. Rev. Food Sci. Nutr.
PD OCT 17
PY 2022
VL 62
IS 29
BP 8161
EP 8177
DI 10.1080/10408398.2021.1925870
EA MAY 2021
PG 17
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA 5D4SN
UT WOS:000651277700001
PM 33998846
DA 2025-06-11
ER

PT J
AU Kraal, T
   Lübbers, J
   van den Bekerom, MPJ
   Alessie, J
   van Kooyk, Y
   Eygendaal, D
   Koorevaar, RCT
AF Kraal, T.
   Lubbers, J.
   van den Bekerom, M. P. J.
   Alessie, J.
   van Kooyk, Y.
   Eygendaal, D.
   Koorevaar, R. C. T.
TI The puzzling pathophysiology of frozen shoulders - a scoping review
SO JOURNAL OF EXPERIMENTAL ORTHOPAEDICS
LA English
DT Review
DE Shoulder; Frozen shoulder; Adhesive capsulitis; Stiffness;
   Pathophysiology; Histology; Etiology
ID GLYCATION END-PRODUCTS; ADHESIVE CAPSULITIS; GROWTH-FACTOR;
   MATRIX-METALLOPROTEINASE; CORACOHUMERAL LIGAMENT; CALCITONIN DEFICIENCY;
   GLENOHUMERAL JOINT; SUPERVISED NEGLECT; METABOLIC SYNDROME;
   PHYSICAL-THERAPY
AB Purpose The pathophysiology of frozen shoulders is a complex and multifactorial process. The purpose of this review is to scope the currently available knowledge of the pathophysiology of frozen shoulders. Methods A systematic search was conducted in Medline, Embase and the Cochrane library. Original articles published between 1994 and October 2020 with a substantial focus on the pathophysiology of frozen shoulders were included. Results Out of 827 records, 48 original articles were included for the qualitative synthesis of this review. Glenohumeral capsular biopsies were reported in 30 studies. Fifteen studies investigated were classified as association studies. Three studies investigated the pathophysiology in an animal studies. A state of low grade inflammation, as is associated with diabetes, cardiovascular disease and thyroid disorders, predisposes for the development of frozen shoulder. An early immune response with elevated levels of alarmins and binding to the receptor of advance glycation end products is present at the start of the cascade. Inflammatory cytokines, of which transforming growth factor-beta 1 has a prominent role, together with mechanical stress stimulates Fibroblast proliferation and differentiation into myofibroblasts. This leads to an imbalance of extracellular matrix turnover resulting in a stiff and thickened glenohumeral capsule with abundance of type III collagen. Conclusion This scoping review outlines the complexity of the pathophysiology of frozen shoulder. A comprehensive overview with background information on pathophysiologic mechanisms is given. Leads are provided to progress with research for clinically important prognostic markers and in search for future interventions.
C1 [Kraal, T.] Spaarne Gasthuis, Dept Orthopaed Surg, Hoofddorp, Netherlands.
   [Lubbers, J.; van Kooyk, Y.] Amsterdam Univ Med Ctr, Dept Mol Cell Biol & Immunol, Amsterdam, Netherlands.
   [van den Bekerom, M. P. J.] OLVG, Dept Orthopaed Surg, Amsterdam, Netherlands.
   [Alessie, J.] Avans Univ Appl Sci, Breda, Netherlands.
   [Eygendaal, D.] Amsterdam Univ Med Ctr, Dept Orthopaed Surg, Amsterdam, Netherlands.
   [Koorevaar, R. C. T.] Deventer Hosp, Dept Orthopaed Surg, Deventer, Netherlands.
C3 Spaarne Hospital; Onze Lieve Vrouwe Gasthuis Hospital; Deventer Hospital
RP Kraal, T (corresponding author), Spaarne Gasthuis, Dept Orthopaed Surg, Hoofddorp, Netherlands.
EM timkraal@hotmail.com
OI Van Kooyk, Yvette/0000-0001-5997-3665; Lubbers,
   Joyce/0000-0001-9265-5108
FU ReumaNederland [2019-1-675111]; Amphia Scientific Institute
FX One of the authors (JL) is financially supported by ReumaNederland
   (grant 2019-1-675111). Costs of open access publication was supported by
   the Amphia Scientific Institute.
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NR 113
TC 42
Z9 42
U1 4
U2 18
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
EI 2197-1153
J9 J EXP ORTHOP
JI J Exp. Orthop.
PD NOV 18
PY 2020
VL 7
IS 1
AR 91
DI 10.1186/s40634-020-00307-w
PG 15
WC Orthopedics; Surgery
WE Emerging Sources Citation Index (ESCI)
SC Orthopedics; Surgery
GA WD1SH
UT WOS:000704728900001
PM 33205235
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Rai, RC
   Bagul, PK
   Banerjee, SK
AF Rai, Ramesh Chandra
   Bagul, Pankaj K.
   Banerjee, Sanjay Kumar
TI NLRP3 inflammasome drives inflammation in high fructose fed diabetic rat
   liver: Effect of resveratrol and metformin
SO LIFE SCIENCES
LA English
DT Article
DE NLRP3 inflammasome; Pro-inflammatory cytokines; Liver inflammation;
   Diabetes; Resveratrol; Metformin
ID HIGH-FAT DIET; OXIDATIVE STRESS; METABOLIC SYNDROME; ACTIVATION;
   CONSUMPTION; EPIDEMIC; DISEASE; PROTEIN; ACID
AB Aims: To unravel the underlying mechanism of hepatic inflammation during type 2 diabetes (T2DM), we established the diabetic rat model by feeding with high fructose diet for twenty weeks and studied the involvement of inflammasome in the liver of these rats.
   Materials and methods: Male SD rats weighing 180-200 g were divided in four groups: 1) Control (Con group) rats were fed with corn starch diet, 2) diabetic (Dia group) rats were fed with 65% of fructose, 3) diabetic along with resveratrol (10 mg/kg/day); p.o. (Dia + Resv group) and 4) diabetic along with metformin (300 mg/kg/day); p.o. (Dia + met group), for twenty weeks. We evaluated the establishment of T2DM in fructose fed rats and the effect of resveratrol and metformin treatment on different diabetic parameters in these rats. Further we investigated the role of NLRP3 inflammasome on T2DM induced liver inflammation and effect of resveratrol and metformin treatment on NLRP3 inflammasome driven inflammatory response.
   Key findings: Rats from Dia group; manifested insulin resistance, hyperinsulinemia, hyperglycemia, elevated uric acid along with hypertriglyceridemia after fructose feeding for twenty weeks. Mostly, above parameters were attenuated in resveratrol and metformin treated groups. Expression of NLRP3 inflammasome components in liver were increased in Dia group rats with elevated transcript levels of pro-inflammatory cytokines. Histopathological examination revealed increase in glycogen content and fibrosis in Dia group rats; which was considerably reduced with resveratrol and metformin treatment.
   Significance: Our study suggests that management of inflammation may be considered as an alternative approach to prevent liver tissue injury during chronic diabetic condition.
C1 [Rai, Ramesh Chandra] Int Ctr Genet Engn & Biotechnol ICGEB, Immunol Grp, Aruna Asaf Ali Marg, New Delhi 110067, India.
   [Bagul, Pankaj K.; Banerjee, Sanjay Kumar] Translat Hlth Sci & Technol Inst THSTI, Faridabad 121001, India.
   [Banerjee, Sanjay Kumar] Natl Inst Pharmaceut Educ & Res NIPER, Dept Biotechnol, Gauhati 781101, India.
   [Banerjee, Sanjay Kumar] CSIR Indian Inst Chem Technol, Div Med Chem & Pharmacol, Hyderabad 500007, India.
C3 Department of Biotechnology (DBT) India; International Center for
   Genetic Engineering & Biotechnology (ICGEB); International Center for
   Genetic Engineering & Biotechnology (ICGEB), New Delhi; Department of
   Biotechnology (DBT) India; Translational Health Science & Technology
   Institute (THSTI); National Institute of Pharmaceutical Education &
   Research, S.A.S. Nagar (Mohali); Council of Scientific & Industrial
   Research (CSIR) - India; CSIR - Indian Institute of Chemical Technology
   (IICT)
RP Banerjee, SK (corresponding author), Translat Hlth Sci & Technol Inst THSTI, Faridabad 121001, India.; Rai, RC (corresponding author), Int Ctr Genet Engn & Biotechnol, Aruna Asaf Ali Marg, New Delhi, India.
EM rairamesh@gmail.com; skbanerjee@thsti.res.in
RI Banerjee, Sanjay/F-2677-2019; Dr. Pankaj K. Bagul, M.S/I-3867-2012
OI Banerjee, Sanjay k/0000-0002-0044-0984; Banerjee,
   Sanjay/0000-0002-0008-0480
FU Translational Health Science and Technology Institute (THSTI),
   Faridabad, India; Department of Biotechnology, Government of Inida
   [0BT/PR6143/FNS/20/637/2012]; CSIR, Government of India; Department of
   Biotechnology, Government of India
FX The research work was supported by intramural grant from Translational
   Health Science and Technology Institute (THSTI), Faridabad, India and
   Department of Biotechnology, Government of Inida
   (0BT/PR6143/FNS/20/637/2012). PKB was supported by CSIR, Government of
   India for his fellowship (SRF). R C Rai was financially supported by
   project grant from Department of Biotechnology, Government of India.
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NR 56
TC 26
Z9 28
U1 1
U2 21
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0024-3205
EI 1879-0631
J9 LIFE SCI
JI Life Sci.
PD JUL 15
PY 2020
VL 253
AR 117727
DI 10.1016/j.lfs.2020.117727
PG 9
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA MM0MF
UT WOS:000549853700008
PM 32371063
DA 2025-06-11
ER

PT J
AU Viedma-Rodríguez, R
   Martínez-Hernández, MG
   Martínez-Torres, DI
   Baiza-Gutman, LA
AF Viedma-Rodriguez, Rubi
   Martinez-Hernandez, Maria Guadalupe
   Martinez-Torres, Dante Israel
   Baiza-Gutman, Luis Arturo
TI Epithelial Mesenchymal Transition and Progression of Breast Cancer
   Promoted by Diabetes Mellitus in Mice Are Associated with Increased
   Expression of Glycolytic and Proteolytic Enzymes
SO HORMONES & CANCER
LA English
DT Article
DE Diabetes; Breast cancer; uPA; uPAR system; Epithelial mesenchymal
   transition
ID HIGH GLUCOSE; CELLS; HYPERGLYCEMIA; INVASIVENESS
AB The development of breast cancer (BC) is influenced by age, overweight, obesity, metabolic syndrome, and diabetes mellitus (DM), which are associated with hyperglycemia, glucose intolerance, insulin resistance, and oxidative stress. High glucose concentration increases a metastatic phenotype in cultured breast cancer cells, promoting cell proliferation, reactive species production (ROS), epithelial mesenchymal transition (EMT), and expression of proteolytic enzymes. Our aim was to determine whether diabetes mellitus favor BC progression in mice and its association with changes in the content of ROS and glycolytic and proteolytic enzymes. Diabetes was induced in 7-week-old Balb/c mice, under 6-h fasting with a unique i. p. dose of streptozotocin 120 mg/kg. Furthermore, 4T1 breast cancer cells were injected beneath the nipple to induce tumors. G6PD, GAPDH, ENO1, uPA, uPAR, PAI-1, beta-catenin, Snail, vimentin, and E-cadherin were measured by western blot and MPP-9 and MMP-2 by gel zymography. TBARS were measured as markers of the lipid peroxidation. Lower survival and increased tumor growth, together with marked EMT, were found in diabetic in comparison with nondiabetic mice. The effects of diabetes were associated with enhanced lipid peroxidation and higher levels of glycolytic (G6PD, GAPDH, and ENO1) and proteolytic (uPA, MMP-9) enzymes. Possibly, hyperglycemia and ROS led to faster progression of breast cancer in diabetic mice, fomenting EMT and the expression of glycolytic and proteolytic enzymes. These enzymes participate in the supply of energy and precursors for macromolecular biosynthesis and extracellular matrix degradation during breast cancer progression.
C1 [Viedma-Rodriguez, Rubi; Martinez-Hernandez, Maria Guadalupe; Martinez-Torres, Dante Israel; Baiza-Gutman, Luis Arturo] Univ Nacl Autonoma Mexico, Fac Estudios Super Iztacala, Unidad Morfol & Func, Ave Barrios 1, Tlalnepantla 54090, Estado De Mexic, Mexico.
C3 Universidad Nacional Autonoma de Mexico
RP Baiza-Gutman, LA (corresponding author), Univ Nacl Autonoma Mexico, Fac Estudios Super Iztacala, Unidad Morfol & Func, Ave Barrios 1, Tlalnepantla 54090, Estado De Mexic, Mexico.
EM labaiza@unam.mx
RI Baiza-Gutman, Luis/H-9160-2019
OI Baiza-Gutman, Luis Arturo/0000-0002-3669-4185
FU Programa de Apoyo a Proyectos de Investigacion e Innovacion Tecnologica
   (PAPIIT); Direccion General de Asuntos del Personal Academico (DGAPA);
   Universidad Nacional Autonoma de Mexico (UNAM) [IN220818, IA206920]
FX This work was supported by the Programa de Apoyo a Proyectos de
   Investigacion e Innovacion Tecnologica (PAPIIT), Direccion General de
   Asuntos del Personal Academico (DGAPA), and Universidad Nacional
   Autonoma de Mexico (UNAM), projects IN220818 and IA206920.
   Viedma-Rodriguez R was postdoctoral fellow of DGAPA, UNAM, during the
   realization of this study.
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NR 45
TC 12
Z9 13
U1 1
U2 6
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1868-8497
EI 1868-8500
J9 HORM CANCER-US
JI Horm. Cancer
PD AUG
PY 2020
VL 11
IS 3-4
BP 170
EP 181
DI 10.1007/s12672-020-00389-z
EA JUN 2020
PG 12
WC Oncology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Endocrinology & Metabolism
GA MF2XX
UT WOS:000540969300001
PM 32557212
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Chen, K
   Chen, X
   Xue, HL
   Zhang, PW
   Fang, WJ
   Chen, XC
   Ling, WH
AF Chen, Ke
   Chen, Xu
   Xue, Hongliang
   Zhang, Peiwen
   Fang, Wanjun
   Chen, Xuechen
   Ling, Wenhua
TI Coenzyme Q10 attenuates high- fat diet- induced non- alcoholic fatty
   liver disease through activation of the AMPK pathway
SO FOOD & FUNCTION
LA English
DT Article
ID HEPATIC STEATOSIS; OXIDATIVE STRESS; DOUBLE-BLIND; NONALCOHOLIC
   STEATOHEPATITIS; INSULIN-RESISTANCE; METABOLIC SYNDROME; PROTEIN-KINASE;
   RISK-FACTORS; SUPPLEMENTATION; PREVALENCE
AB Coenzyme Q10 (CoQ10) is a well-known anti-adipogenic factor that possesses the capability to regulate non-alcoholic fatty liver disease (NAFLD). However, the mechanism by which CoQ10 acts on NAFLD is still unclear. In this study, the role of CoQ10 in the prevention of NAFLD was investigated in vivo and in vitro. C57BL/6J mice were fed a normal diet, high-fat diet (HFD) or HFD supplemented with CoQ10 (1800 mg kg(-1) HFD) for 24 weeks. HepG2 cells were treated with sodium palmitate for investigating the mechanism of action of CoQ10 on NAFLD. The results showed that CoQ10 alleviated HFD-induced weight gain and NAFLD, accompanied by an anti-hyperlipidaemia effect, by reducing the serum triglycerides, total cholesterol, and low-density lipoprotein cholesterol levels. Importantly, CoQ10 could downregulate the expression of sterol regulatory element-binding protein-1c (SREBP-1c), acetyl-CoA carboxylase (ACC), and fatty acid synthase (FAS), which are related to lipid synthesis, and upregulate the expression of peroxisome proliferator-activated receptors (PPAR) and carnitine palmitoyltransferase-1 (CPT-1) associated with fatty acid oxidation. Similar to the results from mice, treatment with CoQ10 alleviated sodium palmitate-induced hepatocyte steatosis via the inhibition of lipogenesis and promotion of fatty acid oxidation. However, Compound C, as an AMPK inhibitor, could significantly block the benefits derived from CoQ10 treatment. In conclusion, CoQ10 could serve as an AMPK activator and regulate the hepatic lipid metabolism to inhibit the abnormal accumulation of hepatic lipids and prevent NAFLD progression.
C1 [Chen, Ke; Chen, Xu; Xue, Hongliang; Zhang, Peiwen; Fang, Wanjun; Chen, Xuechen; Ling, Wenhua] Sun Yat Sen Univ, Sch Publ Hlth, Dept Nutr, Guangzhou, Guangdong, Peoples R China.
   [Ling, Wenhua] Guangdong Prov Key Lab Food Nutr & Hlth, Guangzhou, Guangdong, Peoples R China.
C3 Sun Yat Sen University
RP Ling, WH (corresponding author), Sun Yat Sen Univ, Sch Publ Hlth, Dept Nutr, Guangzhou, Guangdong, Peoples R China.; Ling, WH (corresponding author), Guangdong Prov Key Lab Food Nutr & Hlth, Guangzhou, Guangdong, Peoples R China.
EM lingwh@mail.sysu.edu.cn
RI Chen, Xuechen/MAI-5421-2025; Xue, Hongliang/JVP-3392-2024; Chen,
   Xu/KMX-8502-2024; Chen, Ke/HPC-6767-2023
OI Chen, Xu/0000-0002-0545-3936
FU key Project of the National Natural Science Fund [81730090]
FX K. C. and W. H. L. designed the study; K. C., X. C., W. J. F., H. L. X.
   and X. C. C. performed the experiments; and K. C. analyzed the data and
   wrote the manuscript. All authors read and approved the manuscript to be
   published. This work was supported and funded by the key Project of the
   National Natural Science Fund (grant number: 81730090).
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NR 44
TC 65
Z9 68
U1 1
U2 75
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PD FEB 1
PY 2019
VL 10
IS 2
BP 814
EP 823
DI 10.1039/c8fo01236a
PG 10
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA HP3JM
UT WOS:000461572900026
PM 30675881
DA 2025-06-11
ER

PT J
AU Feng, Y
   Chen, Y
   Yang, BR
   Lan, QP
   Wang, T
   Cui, GZ
   Ren, ZT
   Choi, IC
   Leung, GPH
   Yan, FG
   Chen, DC
   Yu, HH
   Lee, SMY
AF Feng, Yu
   Chen, Yan
   Yang, Binrui
   Lan, Qingping
   Wang, Tao
   Cui, Guozhen
   Ren, Zhitao
   Choi, I. Cheong
   Leung, George Pak-Heng
   Yan, Fenggen
   Chen, Dacan
   Yu, Hon Ho
   Lee, Simon Ming Yuen
TI Hepatoprotective Effect of Jianpi Huoxue Formula on Nonalcoholic Fatty
   Liver Disease Induced by Methionine-Choline-Deficient Diet in Rat
SO BIOMED RESEARCH INTERNATIONAL
LA English
DT Article
ID TRADITIONAL CHINESE MEDICINE; OXIDATIVE STRESS; HEPATIC STEATOSIS;
   ANIMAL-MODELS; STEATOHEPATITIS; PATHOGENESIS; EPIDEMIOLOGY;
   INFLAMMATION; PREVALENCE; GUIDELINE
AB In parallel with the prevalence metabolic syndrome, nonalcoholic fatty liver disease (NAFLD) has become the most common chronic liver disease in most countries. It features a constellation of simple steatosis, nonalcoholic steatohepatitis (NASH), fibrosis, cirrhosis, and even hepatocellular carcinoma. There are no approved drugs for effective management of NAFLD and NASH. Jianpi Huoxue formula (JPHX) mainly consists of Atractylodes macrocephal (Baizhu), Salvia miltiorrhiza (Danshen), Rasux Paeonia Alba (Baishao), Rhizoma Alismatis (Zexie), and Fructus Schisandrae Chinensis (Wuweizi), which may have beneficial effects on NAFLD. The aim of the study was to identify the effect of JPHX on NAFLD. A NAFLD model was induced by methionine-choline-deficient food (MCD) in Wistar rats and orally administered with simultaneous JPHX, once a day for 8 weeks. Hepatocellular injury, lipid profile, inflammation, fibrosis, and apoptosis were evaluated. The results showed that JPHX significantly decreased the abnormal serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels compared with the MCD model (P<0.05). Furthermore, JPHX protected MCD diet-fed rats from accumulation of hepatic triglycerides (TG) and total cholesterol (TC). Histological examination demonstrated that JPHX noticeably normalized the NAFLD activity score (NAS). Moreover, JPHX ameliorated liver inflammation by decreasing TNF-alpha levels and reduced collagen and matrix metalloproteinases in MCD diet-fed rats. In addition, JPHX prevented rats from MCD-induced cellular apoptosis, as suggested by TUNEL staining, and suppressed the activation of caspase 3 and 7 proteins. JPHX also inhibited the phosphorylation of JNK. In conclusion, JPHX exhibited a hepatoprotective effect against NAFLD in an MCD experimental model.
C1 [Feng, Yu; Chen, Yan; Yang, Binrui; Lan, Qingping; Cui, Guozhen; Ren, Zhitao; Lee, Simon Ming Yuen] Univ Macau, State Key Lab Qual Res Chinese Med, Macau, Peoples R China.
   [Feng, Yu; Chen, Yan; Yang, Binrui; Lan, Qingping; Cui, Guozhen; Ren, Zhitao; Lee, Simon Ming Yuen] Univ Macau, Inst Chinese Med Sci, Macau, Peoples R China.
   [Wang, Tao; Cui, Guozhen] Zhuhai Campus Zunyi Med Univ, Dept Bioengn, Zhuhai, Peoples R China.
   [Choi, I. Cheong; Yu, Hon Ho] Kiang Wu Hosp, Dept Gastroenterol, Macau, Peoples R China.
   [Leung, George Pak-Heng] Univ Hong Kong, Dept Pharmacol & Pharm, Hong Kong, Peoples R China.
   [Yan, Fenggen; Chen, Dacan] Guangzhou Univ Chinese Med, Affiliated Hosp 2, Guangdong Prov Hosp Chinese Med, Guangzhou, Guangdong, Peoples R China.
C3 University of Macau; University of Macau; University of Hong Kong;
   Guangzhou University of Chinese Medicine
RP Lee, SMY (corresponding author), Univ Macau, State Key Lab Qual Res Chinese Med, Macau, Peoples R China.; Lee, SMY (corresponding author), Univ Macau, Inst Chinese Med Sci, Macau, Peoples R China.; Yu, HH (corresponding author), Kiang Wu Hosp, Dept Gastroenterol, Macau, Peoples R China.
EM yuhonho@gmail.com; simonlee@umac.mo
RI fenggen, yan/F-6815-2011; Guozhen, cui/C-5784-2009; Fuchs,
   Christiane/AAE-9892-2019; REN, Zhitao/HGB-3367-2022; Leung, George Pak
   Heng/B-4529-2009
OI Cui, Guozhen/0000-0002-7639-2456; lee, Simon Ming
   Yuen/0000-0002-3966-6569; Leung, George Pak Heng/0000-0003-3529-9367;
   YANG, BINRUI/0000-0003-2160-2273
FU Research Committee, University of Macau [MYRG2016-00129-ICMS-QRCM];
   Science and Technology Development Fund (FDCT) of Macao SAR
   [276/2017/A]; Shanghai Sunrise Traditional Chinese Medicine Co., Ltd.
   (Shanghai, China)
FX This work was supported by grants from the Research Committee,
   University of Macau (Ref. no. MYRG2016-00129-ICMS-QRCM), the Science and
   Technology Development Fund (FDCT) of Macao SAR (Grants 276/2017/A), and
   Shanghai Sunrise Traditional Chinese Medicine Co., Ltd. (Shanghai,
   China).
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NR 53
TC 15
Z9 16
U1 1
U2 21
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2314-6133
EI 2314-6141
J9 BIOMED RES INT
JI Biomed Res. Int.
PY 2019
VL 2019
AR 7465272
DI 10.1155/2019/7465272
PG 12
WC Biotechnology & Applied Microbiology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Research & Experimental Medicine
GA IJ0FG
UT WOS:000475575200001
PM 31355279
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Tekin, I
   Edem, E
AF Tekin, Isik
   Edem, Efe
TI Association of Epicardial Fat Tissue with Coronary Artery Disease and
   Left Ventricle Diastolic Function Indicators
SO MEDICAL SCIENCE MONITOR
LA English
DT Article
DE Coronary Artery Disease; Echocardiography; Heart Failure, Diastolic
ID ADIPOSE-TISSUE; CARDIOVASCULAR RISK; METABOLIC SYNDROME; HYPERTENSIVE
   PATIENTS; PERICARDIAL FAT; THICKNESS; EXPRESSION; SEVERITY;
   ECHOCARDIOGRAPHY; DYSFUNCTION
AB Background: Epicardial fat tissue (EAT) acts as brown adipose tissue and protects the heart and coronary arteries against hypothermia. Recent studies demonstrated that EAT is a source of both anti-inflammatory and atherogenic cytokines. In this study, our aim was to investigate the association of vertical, horizontal, and area measurements of EAT thickness and their association with coronary artery disease, diastolic function, and myocardial performance index in patients who underwent coronary angiography.
   Material/Methods: The study population consisted of patients who presented to our outpatient clinic with chest pain and whose non-invasive stress tests were positive between June 2015 and July 2017. Echocardiographic examinations were performed prior to the angiography. Coronary angiograms were performed using Judkins method from the femoral artery.
   Results: Mean vertical thickness of EAT was 0.6 cm in patients with CAD and 0.46 cm in those without CAD (p=0.0001). Mean horizontal length of EAT was 2.91 cm in patients with CAD and was 2.41 cm in the subjects without CAD (p=0.001). ROC analysis showed 81% sensitivity and 53% specificity for a cut-off value of 0.45, and 67% sensitivity and 71% specificity for a cut-off value of 0.55 for EAT vertical (cm). Multivariate analysis showed that EAT is an independent risk factor for coronary artery disease.
   Conclusions: Echocardiography is an inexpensive routine assessment for most patients. EAT thickness determined by echo- cardiography may be a useful indicator of increased CAD risk, but not diastolic dysfunction, of the left ventricle.
C1 [Tekin, Isik] Tarsus State Hosp, Dept Cardiol, Mersin, Turkey.
   [Edem, Efe] Tinaztepe Hosp, Dept Cardiol, Izmir, Turkey.
C3 Tinaztepe Hospital
RP Edem, E (corresponding author), Tinaztepe Hosp, Dept Cardiol, Izmir, Turkey.
EM edemefe@gmail.com
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NR 35
TC 8
Z9 8
U1 0
U2 2
PU INT SCIENTIFIC LITERATURE, INC
PI MELVILLE
PA 150 BROADHOLLOW RD, STE 114, MELVILLE, NY 11747 USA
SN 1643-3750
J9 MED SCI MONITOR
JI Med. Sci. Monitor
PD SEP 11
PY 2018
VL 24
BP 6367
EP 6374
DI 10.12659/MSM.910989
PG 8
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA GT6JG
UT WOS:000444616200004
PM 30205415
OA Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Tassone, EJ
   Cimellaro, A
   Perticone, M
   Hribal, ML
   Sciacqua, A
   Andreozzi, F
   Sesti, G
   Perticone, F
AF Tassone, Eliezer J.
   Cimellaro, Antonio
   Perticone, Maria
   Hribal, Marta L.
   Sciacqua, Angela
   Andreozzi, Francesco
   Sesti, Giorgio
   Perticone, Francesco
TI Uric Acid Impairs Insulin Signaling by Promoting Enpp1 Binding to
   Insulin Receptor in Human Umbilical Vein Endothelial Cells
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Article
DE uric acid; insulin resistance; insulin signaling; ectonucleotide
   pyrophosphatase phosphodiesterase; endothelium; nitric oxide; vascular
   damage
ID C-REACTIVE PROTEIN; OXIDATIVE STRESS; ESSENTIAL-HYPERTENSION; VASCULAR
   ENDOTHELIUM; METABOLIC SYNDROME; DIABETES-MELLITUS; NITRIC-OXIDE;
   RISK-FACTOR; NEW-ONSET; DYSFUNCTION
AB High levels of uric acid (UA) are associated with type-2 diabetes and cardiovascular disease. Recent pieces of evidence attributed to UA a causative role in the appearance of diabetes and vascular damage. However, the molecular mechanisms by which UA induces these alterations have not been completely elucidated so far. Among the mechanisms underlying insulin resistance, it was reported the role of a transmembrane glycoprotein, named either ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) or plasma cell antigen 1, which is able to inhibit the function of insulin receptor (I-R) and it is overexpressed in insulin-resistant subjects. In keeping with this, we stimulated human umbilical vein endothelial cells (HUVECs) with insulin and UA to investigate the effects of UA on insulin signaling pathway, testing the hypothesis that UA can interfere with insulin signaling by the activation of ENPP1. Cultures of HUVECs were stimulated with insulin, UA and the urate transporter SLC22Al2 (URAT1) inhibitor probenecid. Akt and endothelial nitric oxide synthase (eNOS) phosphorylation levels were investigated by immunoblotting. ENPP1 binding to I-R and its tyrosine phosphorylation levels were tested by immunoprecipitation and immunoblotting. UA inhibited insulin-induced Akt/eNOS axis. Moreover, UA induced ENPP1 binding to I-n, that resulted in an impairment of insulin signaling cascade. Probenecid reverted UA effects, suggesting that UA intracellular uptake is required for its action. In endothelial cells, UA directly interferes with insulin signaling pathway at receptor level, through ENPP1 recruitment. This evidence suggests a new molecular model of UA-induced insulin resistance and vascular damage.
C1 [Tassone, Eliezer J.; Cimellaro, Antonio; Hribal, Marta L.; Sciacqua, Angela; Andreozzi, Francesco; Sesti, Giorgio; Perticone, Francesco] Magna Graecia Univ Catanzaro, Dept Med & Surg Sci, Catanzaro, Italy.
   [Perticone, Maria] Magna Graecia Univ Catanzaro, Dept Expt & Clin Med, Catanzaro, Italy.
C3 Magna Graecia University of Catanzaro; Magna Graecia University of
   Catanzaro
RP Perticone, M (corresponding author), Magna Graecia Univ Catanzaro, Dept Expt & Clin Med, Catanzaro, Italy.
EM mariaperticone@hotmail.com
RI Sesti, Giorgio/B-1509-2012; Perticone, Francesco/I-4260-2017; Perticone,
   Maria/J-9965-2016
OI CIMELLARO, Antonio/0000-0002-5223-4402
CR [Anonymous], N ENGL J MED
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NR 47
TC 39
Z9 42
U1 0
U2 5
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD MAR 26
PY 2018
VL 9
AR 98
DI 10.3389/fendo.2018.00098
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA GA3UJ
UT WOS:000428254800001
PM 29619007
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Jing, LP
   Xia, ML
   Dong, HL
   Lin, JS
   Chen, GD
   Ling, WH
   Chen, YM
AF Jing, Lipeng
   Xia, Mianli
   Dong, Hongli
   Lin, Jiesheng
   Chen, Gengdong
   Ling, Wenhua
   Chen, Yuming
TI Serum Carotenoids Are Inversely Associated with RBP4 and Other
   Inflammatory Markers in Middle-Aged and Elderly Adults
SO NUTRIENTS
LA English
DT Article
DE carotenoids; inflammatory marker; antioxidant; retinol binding protein 4
ID RETINOL-BINDING-PROTEIN; ARTERY RISK DEVELOPMENT; C-REACTIVE PROTEIN;
   CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; OXIDATIVE STRESS;
   BETA-CAROTENE; VITAMIN-E; INSULIN; BIOMARKERS
AB (1) Background: Carotenoids may be inversely associated with inflammatory markers (i.e., TNF-alpha, IL-6, IL-1 beta). However, data are scarce on retinol binding protein 4 (RBP4) in humans. We examined the associations among serum carotenoids, RBP4 and several inflammatory markers in a Chinese population. (2) Methods: This community-based cross-sectional study included 3031 participants (68% males) aged 40-75 years in Guangzhou, China. Serum concentrations of carotenoids, RBP4, and inflammatory markers were measured. (3) Results: Generally, serum individual and total carotenoids were significantly and inversely associated with retinol-adjusted RBP4, RBP4, hsCRP, MCP1, and TNF-alpha levels. Age-and gender-adjusted partial correlation coefficients between total carotenoids and the above inflammatory markers were -0.129, -0.097, -0.159, -0.079, and -0.014 (all p < 0.01, except for TNF-alpha with p > 0.05), respectively. The multivariate-adjusted values of partial correlation coefficients for these inflammation-related markers were -0.098, -0.079, -0.114, -0.090, and -0.079 (all p < 0.01), respectively. Among the individual carotenoids, those with the most predominant association were lutein-zeaxanthin and total carotenoids for retinol-adjusted RBP4 and RBP4, alpha-and beta-carotene for hsCRP, and alpha-carotene for MCP1 and TNF-alpha. No significant associations were observed for IL-6 and IL-1beta. (4) Conclusions: Serum carotenoids were inversely associated with RBP4, hsCRP, MCP1 and TNF-alpha among middle-aged and elderly Chinese adults.
C1 [Jing, Lipeng; Xia, Mianli; Dong, Hongli; Lin, Jiesheng; Chen, Gengdong; Chen, Yuming] Sun Yat Sen Univ, Sch Publ Hlth, Dept Med Stat & Epidemiol, Guangzhou 510080, Guangdong, Peoples R China.
   [Ling, Wenhua; Chen, Yuming] Sun Yat Sen Univ, Sch Publ Hlth, Guangdong Prov Key Lab Food Nutr & Hlth, Guangzhou 510080, Guangdong, Peoples R China.
C3 Sun Yat Sen University; Sun Yat Sen University
RP Chen, YM (corresponding author), Sun Yat Sen Univ, Sch Publ Hlth, Dept Med Stat & Epidemiol, Guangzhou 510080, Guangdong, Peoples R China.; Chen, YM (corresponding author), Sun Yat Sen Univ, Sch Publ Hlth, Guangdong Prov Key Lab Food Nutr & Hlth, Guangzhou 510080, Guangdong, Peoples R China.
EM jinglp@mail2.sysu.edu.cn; xiaomli@mail2.sysu.edu.cn; dhljiyi@163.com;
   linjsh6@mail2.sysu.edu.cn; chgengd@163.com; lingwh@mail.sysu.edu.cn;
   chenyum@mail.sysu.edu.cn
RI Xiao, Mianli/KFS-1851-2024
OI Chen, Gengdong/0000-0001-7180-8099; chen, Yu-ming/0000-0003-1658-5528
FU National Natural Science Foundation of China [81472965, 81730090]; 5010
   Program for Clinical Researches by the Sun Yat-sen University,
   Guangzhou, P. R. China [2007032]
FX This study was jointly supported by the National Natural Science
   Foundation of China (Nos. 81472965 and 81730090), the 5010 Program for
   Clinical Researches (No. 2007032) by the Sun Yat-sen University,
   Guangzhou, P. R. China. The funders had no role in study design, data
   collection and analysis, decision to publish, or preparation of the
   manuscript.
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NR 56
TC 10
Z9 12
U1 1
U2 12
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 2072-6643
J9 NUTRIENTS
JI Nutrients
PD MAR
PY 2018
VL 10
IS 3
AR 260
DI 10.3390/nu10030260
PG 14
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA GA5WT
UT WOS:000428405300001
PM 29495330
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Jiménez, IU
   Díaz-Díaz, E
   Castro, JS
   Ramos, JP
   León, MC
   Ríos, JAA
   Bautista, JCA
   Correa-Rotter, R
   Salinas, CAA
   Larrea, F
AF Uribe Jimenez, Itzel
   Diaz-Diaz, Eulises
   Salmeron Castro, Jorge
   Perez Ramos, Julia
   Cardenas Leon, Mario
   Alvarado Rios, Jose Antonio
   Auriostigue Bautista, Juan Carlos
   Correa-Rotter, Ricardo
   Aguilar Salinas, Carlos Alberto
   Larrea, Fernando
TI Circulating Concentrations of Advanced Glycation end Products, its
   Association With the Development of Diabetes Mellitus
SO ARCHIVES OF MEDICAL RESEARCH
LA English
DT Article
DE AGEs; Insulin resistance; Impaired fasting glucose; Glucose intolerance;
   Diabetes Mellitus
ID METABOLIC SYNDROME; OXIDATIVE STRESS; CHRONIC KIDNEY; CROSS-LINKING;
   COMPLICATIONS; DISEASE; NEPHROPATHY; PROTEIN; SERUM; INFLAMMATION
AB Background. Diabetes Mellitus (DM) is characterized by the production and accumulation of advanced glycation end products (AGEs), which are one of the key mechanisms in the development of its chronic complications.
   Aims of the Study. To assess the serum AGEs concentration by a radioimmunoassay (RIA) developed in our laboratory, to establish reference values in healthy population and to evaluate the diagnostic potential of measuring longitudinal changes in circulating AGEs concentrations to predict the development of DM.
   Methods. Clinical and metabolic parameters were obtained from a cohort of 781 Mexican people, initially and then seven years later. AGEs were quantified by a specific RIA. Associations of the changes in circulating levels of AGEs with the appearance of impaired fasting glucose (IFG), and the development of DM were evaluated.
   Results. Diabetic subjects had higher circulating levels of AGEs than normoglycemic subjects or individuals with IFG in both samples studied (471 vs. 246 and 342 mu U/mL, p <0.001; and 912 vs. 428 and 519 mu U/mL, p <0.001; respectively). A multinomial logistic regression analysis showed that subjects who had AGEs concentration 400 mu U/ml, in the baseline sample had a relative risk ratio of 1.98 to develop IFG seven years later (p = 0.003). While the subjects who had AGEs concentration >= 450 mu U/mL in the baseline sample had a relative risk ratio of 10.7 to develop DM seven years later (p <0.001).
   Conclusions. Circulating AGEs concentration is a good early marker to predict risk of developing DM. (C) 2017 IMSS. Published by Elsevier Inc.
C1 [Uribe Jimenez, Itzel] Univ Autonoma Metropolitana Xochimilco Iztapalapa, Ciencias Biol & Salud, Mexico City, DF, Mexico.
   [Uribe Jimenez, Itzel; Diaz-Diaz, Eulises; Cardenas Leon, Mario; Alvarado Rios, Jose Antonio; Auriostigue Bautista, Juan Carlos; Larrea, Fernando] Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Biol Reprod, Vasco Quiroga 15, Mexico City 14080, DF, Mexico.
   [Salmeron Castro, Jorge] Univ Nacl Autonoma Mexico, Fac Med, Ctr Invest Polit Poblac & Salud, Unidad Acad Invest Epidemiol, Mexico City, DF, Mexico.
   [Perez Ramos, Julia] Univ Autonoma Metropolitana, Unidad Xochimilco, Dept Sistemas Biol, Mexico City, DF, Mexico.
   [Alvarado Rios, Jose Antonio] Univ Nacl Autonoma Mexico, Programa Postgrad Ciencias Bioquim, Mexico City, DF, Mexico.
   [Auriostigue Bautista, Juan Carlos] Univ Nacl Autonoma Mexico, Fac Estudios Super Zaragoza, Mexico City, DF, Mexico.
   [Correa-Rotter, Ricardo] Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Nefrol & Metab Mineral, Mexico City, DF, Mexico.
   [Aguilar Salinas, Carlos Alberto] Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Endocrinol, Mexico City, DF, Mexico.
C3 Universidad Autonoma Metropolitana - Mexico; Instituto Nacional de
   Ciencias Medicas y Nutricion Salvador Zubiran - Mexico; Universidad
   Nacional Autonoma de Mexico; Universidad Autonoma Metropolitana -
   Mexico; University Autonoma Metropolitana Xochimilco; Universidad
   Nacional Autonoma de Mexico; Universidad Nacional Autonoma de Mexico;
   Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran -
   Mexico; Instituto Nacional de Ciencias Medicas y Nutricion Salvador
   Zubiran - Mexico
RP Díaz-Díaz, E (corresponding author), Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Biol Reprod, Vasco Quiroga 15, Mexico City 14080, DF, Mexico.
EM eulisesd@yahoo.com
RI Larrea, Fernando/AAC-1900-2021; Aguilar Salinas, Carlos A/JFS-8212-2023
FU National Council of Science and Technology of Mexico; Program of
   Postdegree in Biological Sciences and Health, Autonomous Metropolitan
   University, Xochimilco Unit, Mexico, DF, Mexico; CONACYT
FX The group of authors gratefully acknowledges the financial support
   granted of Sectorial Fund for Health Research and Social Security, from
   National Council of Science and Technology of Mexico.
   SSA/IMSS/ISSSTE-CONACYT, 2011; the support received from the
   Epidemiological Research Unit and Health Services, Mexican Social
   Security Institute, Cuernavaca, Morelos, for the facilities to
   recruitment of study subjects, and Program of Postdegree in Biological
   Sciences and Health, Autonomous Metropolitan University, Xochimilco
   Unit, Mexico, DF, Mexico. Thanks to CONACYT, for the economic support
   given to Master in Science Itzel Uribe Jimenez for the accomplishment of
   her doctoral study.
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NR 36
TC 17
Z9 20
U1 0
U2 3
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0188-4409
EI 1873-5487
J9 ARCH MED RES
JI Arch. Med. Res.
PD MAY
PY 2017
VL 48
IS 4
BP 360
EP 369
DI 10.1016/j.arcmed.2017.07.001
PG 10
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA FO6XK
UT WOS:000417012300007
PM 29157674
DA 2025-06-11
ER

PT J
AU Satapathy, SK
   Vanatta, JM
   Helmick, RA
   Flowers, A
   Kedia, SK
   Jiang, Y
   Ali, B
   Eason, J
   Nair, SP
   Ibebuogu, UN
AF Satapathy, Sanjaya K.
   Vanatta, Jason M.
   Helmick, Ryan A.
   Flowers, Albert
   Kedia, Satish K.
   Jiang, Yu
   Ali, Bilal
   Eason, James
   Nair, Satheesh P.
   Ibebuogu, Uzoma N.
TI Outcome of Liver Transplant Recipients With Revascularized Coronary
   Artery Disease: A Comparative Analysis With and Without Cardiovascular
   Risk Factors
SO TRANSPLANTATION
LA English
DT Article
ID DOBUTAMINE STRESS ECHOCARDIOGRAPHY; CARDIAC-CATHETERIZATION;
   PREOPERATIVE ASSESSMENT; METABOLIC SYNDROME; PREDICTIVE-VALUE; EVENTS;
   CANDIDATES; INTERVENTIONS; ANGIOGRAPHY; PREVALENCE
AB Background. Coronary artery disease (CAD) is a significant problem during evaluation for liver transplantation (LT). We aim to assess survival in LT recipients based on presence, severity, extent of CAD, and cardiac events within 90 days of LT. Methods. Eighty-seven LT recipients with history of pre-LT angiogram (December 2005 to December 2012) were compared with 2 control groups without prior angiogram, 72 LT recipients matched for cardiovascular risk factors (control group I), and 119 consecutive LT recipients without any CV risk factors (control group II). CAD was assessed by (1) vessel score (>= 50% reduction in luminal diameter), and (2) Extent score (Reardon scoring system). Results. Of the 87 LT recipients (study group), 58 (66.7%) had none or less than 50% stenosis, 29 (33.3%) had obstructive CAD (>= 50% stenosis), 7 (8%) with single-vessel disease, and 22 (25.3%) with multivessel disease. In the study group, irrespective of prerevascularization severity of CAD (P = 0.357), number of segments involved (0, 1-2, > 2 segments, P = 0.304) and extent of CAD based on Reardon score (0, 1-9, > 10, P = 0.224), comparable posttransplant survival was noted. Overall, patient survival in the revascularized CAD group was comparable to angiogram group without obstructive CAD, and both control group I and control group II (P = 0.184, Log Rank). Postoperative cardiac events within 90 days of LT predicted poor survival in study group as well as control groups. Conclusions. Severity or extent of CAD does not impact post-LT survival, if appropriately revascularized. Early postoperative cardiac events are associated with inferior survival in LT recipients, irrespective of underlying CAD.
C1 [Satapathy, Sanjaya K.; Vanatta, Jason M.; Helmick, Ryan A.; Ali, Bilal; Eason, James; Nair, Satheesh P.] Univ Tennessee, Ctr Hlth Sci, Transplant Inst, Methodist Univ Hosp, 1211 Union Ave,Suite 340, Memphis, TN 38104 USA.
   [Flowers, Albert] Univ Tennessee, Ctr Hlth Sci, Dept Internal Med, Memphis, TN 38163 USA.
   [Kedia, Satish K.; Jiang, Yu] Univ Memphis, Sch Publ Hlth, Memphis, TN 38152 USA.
   [Ibebuogu, Uzoma N.] Univ Tennessee, Ctr Hlth Sci, Methodist Univ Hosp, Dept Cardiol, Memphis, TN 38163 USA.
C3 University of Tennessee System; University of Tennessee Health Science
   Center; University of Tennessee System; University of Tennessee Health
   Science Center; University of Memphis; University of Tennessee System;
   University of Tennessee Health Science Center
RP Satapathy, SK (corresponding author), Univ Tennessee, Ctr Hlth Sci, Transplant Inst, Methodist Univ Hosp, 1211 Union Ave,Suite 340, Memphis, TN 38104 USA.
EM ssatapat@uthsc.edu
RI Satapathy, Sanjaya/AAG-9830-2019; Ibebuogu, Uzoma/HLQ-0954-2023
OI Helmick, Ryan/0000-0002-8819-9522; Satapathy,
   Sanjaya/0000-0003-0153-2829
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NR 34
TC 50
Z9 51
U1 0
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0041-1337
EI 1534-6080
J9 TRANSPLANTATION
JI Transplantation
PD APR
PY 2017
VL 101
IS 4
BP 793
EP 803
DI 10.1097/TP.0000000000001647
PG 11
WC Immunology; Surgery; Transplantation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Surgery; Transplantation
GA EQ5XU
UT WOS:000398157200034
PM 28099403
OA Green Published
DA 2025-06-11
ER

PT J
AU Mazidi, M
   Kengne, AP
   Banach, M
AF Mazidi, Mohsen
   Kengne, Andre-Pascal
   Banach, Maciej
TI Mineral and vitamin consumption and telomere length among adults in the
   United States
SO POLISH ARCHIVES OF INTERNAL MEDICINE-POLSKIE ARCHIWUM MEDYCYNY
   WEWNETRZNEJ
LA English
DT Article
DE dietary pattern; factor analysis; telomere length
ID US ADULTS; CARDIOVASCULAR-DISEASE; COFFEE CONSUMPTION; METABOLIC
   SYNDROME; OXIDATIVE STRESS; DIETARY PATTERNS; FOOD GROUPS; LIFE-STYLE;
   ASSOCIATION; POPULATION
AB INTRODUCTION Shorter leukocyte telomere length (TL) is associated with several chronic diseases, but only a few studies have assessed the associations of dietary components and dietary patterns with TL in adults in the United States (US).
   OBJECTIVES This study was aimed to determine the relation of dietary components and dietary patterns with TL among adults in the US.
   PATIENTS AND METHODS National Health and Nutrition Examination Survey (NHANES) participants with data on dietary intake and TL measures from 1999 to 2001 were included. Daily intakes of 60 nutrients and bioactive compounds were calculated for each participant. Factor analysis, followed by a varimax rotation, was applied to derive the major nutrient patterns. All statistical analyses accounted for the survey design and sample weights.
   RESULTS Of the 10 568 eligible participants, 48.0% (n = 5020) were men; the mean age was 44.1 years. Mean (adjusted for sex, age, and race) dietary intakes of carbohydrate, dietary fiber, total folate, vitamin B-6, magnesium, iron, copper, polyunsaturated fatty acids 22: 5, and vitamin C monotonically increased across TL quarters (P < 0.05 for all), while total fat and caffeine decreased across TL quarters (P < 0.05 for all). Three food patterns together explaining 56.8% of the variance of the dietary nutrient consumption were identified. We found that the second food pattern, which was a representative of minerals and vitamins, monotonically increased across TL quarters and had a positive association with TL.
   CONCLUSIONS Higher mineral and vitamin consumption is associated with longer telomeres among adults in the US.
C1 [Mazidi, Mohsen] Chinese Acad Sci, Inst Genet & Dev Biol, Key State Lab Mol Dev Biol, Beijing, Peoples R China.
   [Mazidi, Mohsen] Univ Chinese Acad Sci, Inst Genet & Dev Biol, Int Coll, Beijing, Peoples R China.
   [Kengne, Andre-Pascal] South African Med Res Council, Noncommunicable Dis Res Unit, Cape Town, South Africa.
   [Kengne, Andre-Pascal] Univ Cape Town, Cape Town, South Africa.
   [Banach, Maciej] Med Univ Lodz, Dept Hypertens, Chair Nephrol & Hypertens, Lodz, Poland.
   [Banach, Maciej] HARC, Lodz, Poland.
C3 Chinese Academy of Sciences; Institute of Genetics & Developmental
   Biology, CAS; Chinese Academy of Sciences; University of Chinese Academy
   of Sciences, CAS; Institute of Genetics & Developmental Biology, CAS;
   South African Medical Research Council; University of Cape Town; Medical
   University Lodz
RP Mazidi, M (corresponding author), Chinese Acad Sci, Inst Genet & Dev Biol, Key State Lab Mol Dev Biol, Beijing, Peoples R China.
EM moshen@genetics.ac.cn
RI Linn, Shai/N-3079-2019; Kengne, Andre/ABB-3696-2020; Banach,
   Maciej/A-1271-2009
OI Banach, Maciej/0000-0001-6690-6874; Kengne, Andre
   Pascal/0000-0002-5183-131X
FU TWAS studentship of the Chinese Academy of Sciences; Healthy Ageing
   Research Centre project of Medical University of Lodz, Lodz, Poland
   [REGPOT-2012-2013-1]
FX MM was supported by a TWAS studentship of the Chinese Academy of
   Sciences, during the preparation of this manuscript. MB is partially
   supported by the Healthy Ageing Research Centre project of Medical
   University of Lodz, Lodz, Poland (REGPOT-2012-2013-1, 7FP).
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NR 32
TC 52
Z9 54
U1 0
U2 11
PU MEDYCYNA PRAKTYCZNA
PI KRAKOW
PA UL KRAKOWSKA 41, KRAKOW, 31-066, POLAND
SN 0032-3772
EI 1897-9483
J9 POL ARCH INTERN MED
JI Pol. Intern. Med.
PY 2017
VL 127
IS 2
BP 87
EP 90
DI 10.20452/pamw.3927
PG 4
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA EN1CI
UT WOS:000395747600002
PM 28150689
DA 2025-06-11
ER

PT J
AU García-Arévalo, M
   Alonso-Magdalena, P
   Servitja, JM
   Boronat-Belda, T
   Merino, B
   Villar-Pazos, S
   Medina-Gómez, G
   Novials, A
   Quesada, I
   Nadal, A
AF Garcia-Arevalo, Marta
   Alonso-Magdalena, Paloma
   Servitja, Joan-Marc
   Boronat-Belda, Talia
   Merino, Beatriz
   Villar-Pazos, Sabrina
   Medina-Gomez, Gema
   Novials, Anna
   Quesada, Ivan
   Nadal, Angel
TI Maternal Exposure to Bisphenol-A During Pregnancy Increases Pancreatic
   β-Cell Growth During Early Life in Male Mice Offspring
SO ENDOCRINOLOGY
LA English
DT Article
ID HIGH-FAT DIET; ESTROGEN-RECEPTOR-BETA; PROMOTES TUMOR-GROWTH;
   INSULIN-RESISTANCE; GLUCOSE-HOMEOSTASIS; PERINATAL EXPOSURE; OXIDATIVE
   STRESS; IN-VIVO; ENDOCRINE PANCREAS; METABOLIC SYNDROME
AB Alterations during development of metabolic key organs such as the endocrine pancreas affect the phenotype later in life. There is evidence that in utero or perinatal exposure to bisphenol-A (BPA) leads to impaired glucose metabolism during adulthood. However, how BPA exposure during pregnancy affects pancreatic beta-cell growth and function in offspring during early life has not been explored. We exposed pregnant mice to either vehicle (control) or BPA (10 and 100 mu g/kg.d, BPA10 and BPA100) and examined offspring on postnatal days (P) P0, P21, P30, and P120. BPA10 and BPA100 mice presented lower birth weight than control and subsequently gained weight until day 30. At that age, concentration of plasma insulin, C-peptide, and leptin were increased in BPA-exposed animals in the nonfasting state. Insulin secretion and content were diminished in BPA10 and maintained in BPA100 compared with control. A global gene expression analysis indicated that genes related with cell division were increased in islets from BPA-treated animals. This was associated with an increase in pancreatic beta-cell mass at P0, P21, and P30 together with increased beta-cell proliferation and decreased apoptosis. On the contrary, at P120, BPA-treated animals presented either equal or decreased beta-cell mass compared with control and altered fasting glucose levels. These data suggest that in utero exposure to environmentally relevant doses of BPA alters the expression of genes involved in beta-cell growth regulation, incrementing beta-cell mass/area, and beta-cell proliferation during early life. An excess of insulin signaling during early life may contribute to impaired glucose tolerance during adulthood.
C1 [Garcia-Arevalo, Marta; Boronat-Belda, Talia; Merino, Beatriz; Villar-Pazos, Sabrina; Quesada, Ivan; Nadal, Angel] Miguel Hernandez Univ Elche, Inst Bioengn, Ave Univ S-N, Alicante 03202, Spain.
   [Alonso-Magdalena, Paloma] Miguel Hernandez Univ Elche, Dept Appl Biol, Alicante 03202, Spain.
   [Servitja, Joan-Marc; Novials, Anna] Hosp Clin Barcelona, Diabet & Obes Res Lab, Inst Invest Biomed August Pi & Sunyer, E-08036 Barcelona, Spain.
   [Garcia-Arevalo, Marta; Alonso-Magdalena, Paloma; Servitja, Joan-Marc; Boronat-Belda, Talia; Merino, Beatriz; Villar-Pazos, Sabrina; Novials, Anna; Quesada, Ivan; Nadal, Angel] Ctr Invest Biomed Red Diabet & Enfermedades Metab, Madrid, Spain.
   [Medina-Gomez, Gema] Rey Juan Carlos Univ, Dept Basic Sci Hlth, Area Biochem & Mol Biol, Madrid 28922, Spain.
C3 Universidad Miguel Hernandez de Elche; Universidad Miguel Hernandez de
   Elche; University of Barcelona; Hospital Clinic de Barcelona; IDIBAPS;
   CIBER - Centro de Investigacion Biomedica en Red; CIBERDEM; Universidad
   Rey Juan Carlos
RP Nadal, A (corresponding author), Miguel Hernandez Univ Elche, Inst Bioengn, Ave Univ S-N, Alicante 03202, Spain.
EM nadal@umh.es
RI Boronat Belda, Talía/GYD-4123-2022; Alonso-Magdalena,
   Paloma/AAH-2076-2021; García-Arévalo, Marta/C-9440-2014; Medina-Gomez,
   Gema/F-5667-2016; Nadal, Angel/G-6721-2014; Quesada, Ivan/P-6541-2014;
   MERINO, BEATRIZ/V-4121-2017
OI ALONSO MAGDALENA, PALOMA/0000-0003-1065-5388; Medina-Gomez,
   Gema/0000-0001-8169-681X; Novials, Anna/0000-0003-0465-2949; Villar
   Pazos, Sabrina/0009-0005-7287-1846; Garcia-Arevalo Provencio,
   Marta/0000-0001-7238-9498; SERVITJA, JOAN-MARC/0000-0002-1241-8004;
   Nadal, Angel/0000-0003-4178-2152; Quesada, Ivan/0000-0002-9808-514X;
   Boronat-Belda, Talia/0000-0002-6548-5251; MERINO,
   BEATRIZ/0000-0002-4761-3977
FU Generalitat Valenciana Grant [PROMETEOII/2015/016]; Ministerio de
   Economia y Competitividad [SAF2014-58335-P, BFU2013-42789-P]; EFSD/Lilly
   Fellowship Program [94224]; Sociedad Espanola de Diabetes Grant
   [CY1002IL]
FX This work was supported by Generalitat Valenciana Grant
   PROMETEOII/2015/016, Ministerio de Economia y Competitividad (Grants
   SAF2014-58335-P and BFU2013-42789-P), EFSD/Lilly Fellowship Program
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NR 82
TC 57
Z9 61
U1 0
U2 18
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0013-7227
EI 1945-7170
J9 ENDOCRINOLOGY
JI Endocrinology
PD NOV
PY 2016
VL 157
IS 11
BP 4158
EP 4171
DI 10.1210/en.2016-1390
PG 14
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA EA6YF
UT WOS:000386774400008
PM 27623287
OA Green Submitted, Bronze
DA 2025-06-11
ER

PT J
AU Piao, L
   Jung, I
   Huh, JY
   Miyata, T
   Ha, H
AF Piao, Lingjuan
   Jung, Inji
   Huh, Joo Young
   Miyata, Toshio
   Ha, Hunjoo
TI A novel plasminogen activator inhibitor-1 inhibitor, TM5441, protects
   against high-fat diet-induced obesity and adipocyte injury in mice
SO BRITISH JOURNAL OF PHARMACOLOGY
LA English
DT Article
ID INSULIN-RESISTANCE; MITOCHONDRIAL BIOGENESIS; CONCISE GUIDE;
   PHARMACOLOGY; INFLAMMATION; PUBLICATION; SENSITIVITY; DISRUPTION;
   ADIPOSITY; IMPROVES
AB BACKGROUND AND PURPOSE
   Obesity is one of the most prevalent chronic diseases worldwide, and dysregulated adipocyte function plays an important role in obesity-associatedmetabolic disorder. The level of plasma plasminogen activator inhibitor-1 (PAI-1) is increased in obese subjects, and PAI-1 null mice show improved insulin sensitivity when subjected to high-fat and high-sucrose diet-induced metabolic stress, suggesting that a best-in-class PAI-1 inhibitor may become a novel therapeutic agent for obesity-associated metabolic syndrome. TM5441 is a novel orally active PAI-1 inhibitor that does not cause bleeding episodes. Hence, in the present study we examined the preventive effect of TM5441 on high-fat diet (HFD)-induced adipocyte dysfunction.
   EXPERIMENTAL APPROACH
   Ten-week-old C57BL/6J mice were fed a normal diet (18% of total calories from fat) or HFD (60% of total calories from fat) for 10 weeks, and TM5441 (20 mg.kg(-1) oral gavage) was administered daily with the initiation of HFD.
   KEY RESULTS
   TM5441 prevented HFD-induced body weight gain and systemic insulin resistance. TM5441 normalized HFD-induced dysregulated JNK and Akt phosphorylation, suggesting that it prevents the insulin resistance of adipocytes. TM5441 also attenuated the macrophage infiltration and increased expression of pro-inflammatory cytokines, such as inducible nitric oxide synthase, induced by the HFD. In addition, TM5441 prevented the HFD-induced down-regulation of genes involved in mitochondrial biogenesis and function, suggesting that it may prevent adipocyte inflammation and dysregulation by maintaining mitochondrial fitness.
   CONCLUSION AND IMPLICATIONS
   Our data suggest that TM5441 may become a novel therapeutic agent for obesity and obesity-related metabolic disorders.
C1 [Piao, Lingjuan; Jung, Inji; Ha, Hunjoo] Ewha Womans Univ, Coll Pharm, Grad Sch Pharmaceut Sci, 52 Ewhayeodae Gil, Seoul 120750, South Korea.
   [Huh, Joo Young] Chonnam Natl Univ, Coll Pharm, Gwang Ju, South Korea.
   [Miyata, Toshio] Tohoku Univ, Grad Sch Med, United Ctr Adv Res & Translat Med, Sendai, Miyagi, Japan.
C3 Ewha Womans University; Chonnam National University; Tohoku University
RP Ha, H (corresponding author), Ewha Womans Univ, Coll Pharm, Grad Sch Pharmaceut Sci, 52 Ewhayeodae Gil, Seoul 120750, South Korea.
EM hha@ewha.ac.kr
RI Miyata, Toshio/A-4872-2010
OI Ha, Hunjoo/0000-0002-5601-1265; Piao, Lingjuan/0000-0002-3781-875X
FU NLRL through National Research Foundation (NRF) of Korea
   [2012R1A2A1A0300692]
FX This work was financially supported by NLRL through the National
   Research Foundation (NRF) of Korea (no. 2012R1A2A1A0300692). We are
   grateful to Jung Hwa Lee for her excellent technical assistance.
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NR 43
TC 28
Z9 29
U1 0
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0007-1188
EI 1476-5381
J9 BRIT J PHARMACOL
JI Br. J. Pharmacol.
PD SEP
PY 2016
VL 173
IS 17
BP 2622
EP 2632
DI 10.1111/bph.13541
PG 11
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA DV9KD
UT WOS:000383258400005
PM 27339909
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Yu, S
   Chen, Y
   Hou, X
   Xu, DH
   Che, K
   Li, CG
   Yan, SL
   Wang, YG
   Wang, B
AF Yu, Shuai
   Chen, Ying
   Hou, Xu
   Xu, Donghua
   Che, Kui
   Li, Changgui
   Yan, Shengli
   Wang, Yangang
   Wang, Bin
TI Serum Uric Acid Levels and Diabetic Peripheral Neuropathy in Type 2
   Diabetes: a Systematic Review and Meta-analysis
SO MOLECULAR NEUROBIOLOGY
LA English
DT Review
DE Diabetic peripheral neuropathy; Uric acid; Hyperuricemia
ID METABOLIC SYNDROME; HYPERURICEMIA; RISK; COMPLICATIONS; HYPERTENSION;
   ASSOCIATION; POPULATION; STRESS
AB Previous studies suggested a possible association between serum uric acid levels and peripheral neuropathy in patients with type 2 diabetes, but no definite evidence was available. A systematic review and meta-analysis of relevant studies were performed to comprehensively estimate the association. Pubmed, Web of Science, Embase, and China Biology Medicine (CBM) databases were searched for eligible studies. Study-specific data were combined using random-effect or fixed-effect models of meta-analysis according to between-study heterogeneity. Twelve studies were finally included into the meta-analysis, which involved a total of 1388 type 2 diabetic patients with peripheral neuropathy and 4746 patients without peripheral neuropathy. Meta-analysis showed that there were obvious increased serum uric acid levels in diabetic patients with peripheral neuropathy (weighted mean difference [WMD] = 50.03 mu mol/L, 95 % confidence interval [95%CI] 22.14-77.93, P = 0.0004). Hyperuricemia was also significantly associated with increased risk of peripheral neuropathy in patients with type 2 diabetes (risk ratio [RR] = 2.83, 95%CI 2.13-3.76, P < 0.00001). Meta-analysis of two studies with adjusted risk estimates showed that hyperuricemia was independently associated with increased risk of peripheral neuropathy in type 2 diabetic patients (RR = 1.95, 95%CI 1.23-3.11, P = 0.005). Type 2 diabetic patients with peripheral neuropathy have obvious increased serum uric acid levels, and hyperuricemia is associated with increased risk of peripheral neuropathy. Further prospective cohort studies are needed to validate the impact of serum uric acid levels on peripheral neuropathy risk.
C1 [Yu, Shuai; Chen, Ying; Hou, Xu; Che, Kui; Yan, Shengli; Wang, Yangang; Wang, Bin] Qingdao Univ, Affiliated Hosp, Dept Endocrinol, 16 Jiangsu Rd, Qingdao 266003, Peoples R China.
   [Xu, Donghua] Nanjing Med Univ, Affiliated Hosp 1, Dept Rheumatol, Nanjing 210029, Jiangsu, Peoples R China.
   [Wang, Bin] Essencemed Clin, Weifang 261000, Peoples R China.
   [Li, Changgui] Qingdao Univ, Affiliated Hosp, Shandong Prov Key Lab Metab Dis, Qingdao 266003, Peoples R China.
C3 Qingdao University; Nanjing Medical University; Qingdao University
RP Wang, YG; Wang, B (corresponding author), Qingdao Univ, Affiliated Hosp, Dept Endocrinol, 16 Jiangsu Rd, Qingdao 266003, Peoples R China.
EM nlwang@126.com; robin.wangqy@gmail.com
RI Xu, Donghua/LDO-4979-2024; Wang, Bin/N-3491-2015; Hou, Xu/AAY-4921-2021
OI Li, Changgui/0000-0002-4622-3731
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NR 46
TC 52
Z9 61
U1 1
U2 43
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0893-7648
EI 1559-1182
J9 MOL NEUROBIOL
JI Mol. Neurobiol.
PD MAR
PY 2016
VL 53
IS 2
BP 1045
EP 1051
DI 10.1007/s12035-014-9075-0
PG 7
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA DD8OS
UT WOS:000370187100020
PM 25579387
DA 2025-06-11
ER

PT J
AU Yang, SJ
   Lim, Y
AF Yang, Soo Jin
   Lim, Yunsook
TI Resveratrol ameliorates hepatic metaflammation and inhibits NLRP3
   inflammasome activation
SO METABOLISM-CLINICAL AND EXPERIMENTAL
LA English
DT Article
DE Hepatic metaflammation; NLRP3 inflammasome; Non-alcoholic fatty liver
   disease; Resveratrol; Sirtuin
ID FATTY LIVER-DISEASE; INSULIN-RESISTANCE; IN-VITRO; PROTEIN-KINASE;
   OXIDATIVE STRESS; SKELETAL-MUSCLE; DIET; STEATOSIS; CYTOKINES; MODEL
AB Objective. Resveratrol (RSV) regulates NAD bioavailability and sirtuin-related metabolism, which relates to aging, metabolic syndrome and non-alcoholic fatty liver disease. The purpose of this study was to investigate the effects of resveratrol on hepatic metaflammation in a rodent model of high-fat (HF) diet-induced obesity (DIO).
   Materials/Methods. DIO was induced in a subset of mice given an HF diet (45% kcal fat). After 6 weeks of HF diet feeding, RSV was delivered via an osmotic pump for 4 weeks. The experimental groups were as follows: 1) lean control fed with a standard diet, 2) HF diet-induced obese control, and 3) HF_RSV (8 mg/kg/day). After 4 weeks of each treatment, blood and liver tissues were collected and the indices of glucose control, serum and liver triglyceride (TG), sirtuin pathway, inflammation, and NOD-like receptor family, pryin domain containing 3 (NLRP3) inflammasome were analyzed.
   Results. Body weight and food intake were not altered by administering resveratrol. Glucose control was impaired, and serum and liver TG levels were increased by the HF diet. Hepatic inflammation was aggravated in mice fed with the HF diet, as shown by the increased levels of the pro-inflammatory markers interleukin-1 (IL-1), IL-6 and tumor necrosis factor-alpha in the liver. However, resveratrol administration significantly improved glucose control, and serum and liver TG contents. Also, resveratrol treatment reduced the levels of the pro-inflammatory markers. These improvements were accompanied by alterations in sirtuin pathway and NLRP3 inflammasome activation.
   Conclusion. These results demonstrate that resveratrol ameliorates hepatic metaflammation, accompanied by alterations in NLRP3 inflammasome. (C) 2014 Elsevier Inc. All rights reserved.
C1 [Yang, Soo Jin] Chonnam Natl Univ, Dept Food & Nutr, Kwangju 500757, South Korea.
   [Yang, Soo Jin] Chonnam Natl Univ, Human Ecol Res Inst, Kwangju 500757, South Korea.
   [Lim, Yunsook] Kyung Hee Univ, Dept Food & Nutr, Seoul, South Korea.
C3 Chonnam National University; Chonnam National University; Kyung Hee
   University
RP Yang, SJ (corresponding author), Chonnam Natl Univ, Dept Food & Nutr, Kwangju 500757, South Korea.
EM sjyang89@chonnam.ac.kr
RI Lim, Yunsook/AAI-8996-2020
OI Yang, Soo Jin/0000-0001-7892-7648
FU Basic Science Research Program through the National Research Foundation
   of Korea (NRF); Ministry of Education, Science and Technology
   [NRF-2012R1A1A1004861]; Chonnam National University in Korea
FX This research was supported by grants from Basic Science Research
   Program through the National Research Foundation of Korea (NRF) funded
   by the Ministry of Education, Science and Technology
   (NRF-2012R1A1A1004861) and Chonnam National University (2012) in Korea.
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NR 46
TC 114
Z9 124
U1 1
U2 33
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0026-0495
EI 1532-8600
J9 METABOLISM
JI Metab.-Clin. Exp.
PD MAY
PY 2014
VL 63
IS 5
BP 693
EP 701
DI 10.1016/j.metabol.2014.02.003
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA AG1UC
UT WOS:000335200700012
PM 24629563
DA 2025-06-11
ER

PT J
AU Fimognari, FL
   Scarlata, S
   Antonelli-Incalzi, R
AF Fimognari, Filippo Luca
   Scarlata, Simone
   Antonelli-Incalzi, Raffaele
TI Why are People with "Poor Lung Function" At Increased Atherothrombotic
   Risk?A Critical Review with Potential Therapeutic Indications
SO CURRENT VASCULAR PHARMACOLOGY
LA English
DT Article
DE Lung function; atherothrombotic risk; cardiovascular morbidity;
   cardiovascular mortality
ID C-REACTIVE PROTEIN; OBSTRUCTIVE PULMONARY-DISEASE; NUTRITION EXAMINATION
   SURVEY; CORONARY-HEART-DISEASE; BODY-FAT DISTRIBUTION; AIR-FLOW
   OBSTRUCTION; 1ST NATIONAL-HEALTH; SYSTEMIC INFLAMMATION; INHALED
   CORTICOSTEROIDS; INSULIN-RESISTANCE
AB Patients classified as having a "poor lung function" in large populations studies are at increased risk of atherothrombosis, but potential mechanisms are unclear. A large proportion of these people are affected by chronic obstructive pulmonary disease (COPD), a recognized risk factor for vascular events. Systemic inflammation is the main atherothrombotic abnormality in COPD, but hypoxia-related platelet activation, pro-coagulant status and oxidative stress may play a role. Systemic inflammation is presumably a leading mechanism of atherothrombosis also in people who have a "restrictive" spirometric dysfunction, rather than the classic obstructive pattern of COPD. Many persons with "poor lung function" are affected by diabetes and their cardiovascular risk is therefore linked to the diabetic status. Patients affected by diabetes tend to have a " restrictive" dysfunction, rather than COPD. Recent studies show that restriction at spirometry precedes the onset of diabetes, thereby representing a marker of mechanisms involved in the pre-diabetic, insulin-resistant state. This is also proved by the fact that most patients with metabolic syndrome, a pre-diabetic condition, have a restrictive ventilatory pattern at spirometry. A significant proportion of people with " poor lung function" have visceral obesity, a cardiovascular risk factor. By hampering lung expansion, visceral obesity causes a restrictive ventilatory pattern.
   In conclusion, the term " poor lung function" includes various chronic illnesses with different mechanisms of atherothrombosis. Research is needed for better understanding why persons with lung dysfunctions have higher cardiovascular risk, and for identifying adequate preventive strategies.
C1 [Fimognari, Filippo Luca] Leopoldo Parodi Delfino Hosp, Unit Resp Dis, Div Internal Med, ASL Roma G Colleferro, Rome, Italy.
   [Fimognari, Filippo Luca; Scarlata, Simone; Antonelli-Incalzi, Raffaele] Univ Campus Biomed Rome, Hlth Ctr Elderly, Ctr Salute Anziano, Unit Resp Pathophysiol, I-00128 Rome, Italy.
   [Antonelli-Incalzi, Raffaele] S Raffaele Cittadella Carita Fdn, Taranto, Italy.
C3 University Campus Bio-Medico - Rome Italy
RP Fimognari, FL (corresponding author), Univ Campus Biomed Rome, Ctr Salute Anziano CeSA, Via Alvaro Portillo 2, I-00128 Rome, Italy.
EM filippo.fimognari@virgilio.it
RI Fimognari, Filippo/HJA-3439-2022; Scarlata, Simone/G-6490-2010
OI Antonelli Incalzi, Raffaele/0000-0003-2100-2075
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NR 148
TC 12
Z9 12
U1 0
U2 5
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1570-1611
EI 1875-6212
J9 CURR VASC PHARMACOL
JI Current Vascular Pharmacology
PD JUL
PY 2010
VL 8
IS 4
BP 573
EP 586
PG 14
WC Pharmacology & Pharmacy; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Cardiovascular System & Cardiology
GA 628LZ
UT WOS:000280122900012
PM 19485925
DA 2025-06-11
ER

PT J
AU Migneco, A
   Ojetti, V
   Covino, M
   Mettimano, M
   Montebelli, MR
   Leone, A
   Specchia, L
   Gasbarrini, A
   Savi, L
AF Migneco, A.
   Ojetti, V.
   Covino, M.
   Mettimano, M.
   Montebelli, M. R.
   Leone, A.
   Specchia, L.
   Gasbarrini, A.
   Savi, L.
TI Increased blood pressure variability in menopause
SO EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
LA English
DT Article
DE hypertension; blood pressure variability; woman; menopause
ID NOREPINEPHRINE-INDUCED VASOCONSTRICTION; HORMONE-REPLACEMENT THERAPY;
   BODY-FAT DISTRIBUTION; POSTMENOPAUSAL WOMEN; HEART-RATE; MENTAL STRESS;
   ESSENTIAL-HYPERTENSION; TRANSDERMAL ESTROGEN; CARDIOVASCULAR RISK;
   METABOLIC SYNDROME
AB Blood pressure variability represents an independent risk factor for cardiovascular diseases. To detect possible blood pressure variability changes from fertile to menopausal status, we enrolled consecutively 219 women: 104 fertile women (46.6 +/- 3.4 years) and 115 menopausal women (53.9 +/- 3.98 years). We evaluated for each patient the body mass index (BMI), 24 h, daytime, night-time systolic and diastolic mean blood pressure values and blood pressure variability data by means of an Ambulatory Blood Pressure Monitoring device. We found a significant higher mean age, body mass index, systolic and diastolic 24 h, day and night-time blood pressure variability in menopausal women when compared to fertile women. Age and BMI were significantly correlated to most blood pressure variability data with the Spearman Rank test. The multivariate logistic regression with dichotomic variables showed that the menopausal status is independently correlated to 24 h systolic (p < 0.0005) and diastolic (p < 0.05) variability, systolic (p < 0.05) and diastolic (p < 0.05) daytime pressure variability and systolic night-time pressure variability (p < 0.05). Furthermore, we found independent correlations between age 24h systolic (p < 0.05) and night-time diastolic blood pressure variability (p < 0.05), while the BMI was indepententely correlated to BMI 24h diastolic (p < 0.01), daytime systolic (p < 0.01) and diastolic (p < 0.05) blood pressure variability. These data show a significant increase of blood pressure variability in menopausal women when compared to fertile women, even after exclusion of confounding factors, such as aging and BMI. Menopausal status, aging and BMI increase may all, independently, contribute to the enhanced blood pressure variability we found in menopausal women.
C1 [Migneco, A.; Ojetti, V.; Covino, M.; Leone, A.] Catholic Univ, Emergency Dept, Rome, Italy.
   [Mettimano, M.; Montebelli, M. R.; Specchia, L.; Gasbarrini, A.; Savi, L.] Catholic Univ, Dept Internal Med, Rome, Italy.
C3 Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli;
   Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli
RP Ojetti, V (corresponding author), Catholic Univ, Emergency Dept, Rome, Italy.
EM veronica.ojetti@tin.it
RI Ojetti, V./AFS-4851-2022; Gasbarrini, Antonio/AAB-8487-2019; Covino,
   Marcello/AAR-3596-2020
OI Covino, Marcello/0000-0002-6709-2531; Migneco,
   Alessio/0000-0001-8901-932X; Leone, Antonio/0000-0003-3669-6321;
   Gasbarrini, Antonio/0000-0002-6230-1779
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NR 48
TC 10
Z9 15
U1 0
U2 3
PU VERDUCI PUBLISHER
PI ROME
PA VIA GREGORIO VII, ROME, 186-00165, ITALY
SN 1128-3602
J9 EUR REV MED PHARMACO
JI Eur. Rev. Med. Pharmacol. Sci.
PD MAR-APR
PY 2008
VL 12
IS 2
BP 89
EP 95
PG 7
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 298HT
UT WOS:000255677700003
PM 18575158
DA 2025-06-11
ER

PT J
AU Martínez-Cignoni, MR
   González-Vicens, A
   Morán-Costoya, A
   Amengual-Cladera, E
   Gianotti, M
   Valle, A
   Proenza, AM
   Lladó, I
AF Martinez-Cignoni, Melanie Raquel
   Gonzalez-Vicens, Agusti
   Moran-Costoya, Andrea
   Amengual-Cladera, Emilia
   Gianotti, Magdalena
   Valle, Adamo
   Proenza, Ana Maria
   Llado, Isabel
TI Diabesity alters the protective effects of estrogens on endothelial
   function through adipose tissue secretome
SO FREE RADICAL BIOLOGY AND MEDICINE
LA English
DT Article
DE Adiponectin; Adipovascular axis; Inflammation; Ovariectomy
ID MITOCHONDRIAL BIOGENESIS; INSULIN SENSITIVITY; ER-ALPHA; ADIPONECTIN;
   EXPRESSION; 17-BETA-ESTRADIOL; ACTIVATION; PROTEIN-1; MORTALITY;
   ESTRADIOL
AB Estrogens have a well-known protective role in the development of the metabolic syndrome. Nevertheless, recent epidemiological data question the cardioprotective effect of estrogens in obese and diabetic women. In this context, white adipose tissue (WAT) becomes dysfunctional, which has an impact on the cardiovascular system. The aim of the study was to elucidate the role of 17 beta-estradiol (E2) in the interplay between adipose tissue and endothelial function in an animal model of diabesity. We used ZDF ( fa/fa ) female rats subjected to ovariectomy (OVA), OVA + E2 or sham operated, as well as non-obese non-diabetic ZDF (fa/+) rats. Endothelial function and vascular remodeling markers were assessed in the aorta, while mitochondrial function, oxidative stress, and adiponectin production were analyzed in gonadal WAT. Conditioned media from gonadal WAT explants were used to assess the effects of WAT secretome on HUVEC. Additionally, the adiponectin receptor agonist AdipoRON and E2 were utilized to examine potential interactions. Ovariectomy ameliorated the WAT dysfunction associated to the obese and diabetic state and promoted adiponectin secretion, effects that were linked to a reduction of endothelial dysfunction and inflammatory markers in the aorta of OVA rats and in HUVEC treated with OVA- conditioned media. Our findings provide evidence supporting the idea that in the context of obesity and diabetes, ovariectomy improves WAT secretome and positively impacts endothelial function, suggesting a detrimental role for E2. Additionally, our results point to adiponectin as the primary driver of the effects exerted by ovariectomy on the adipovascular axis.
C1 [Martinez-Cignoni, Melanie Raquel; Gonzalez-Vicens, Agusti; Moran-Costoya, Andrea; Amengual-Cladera, Emilia; Gianotti, Magdalena; Valle, Adamo; Proenza, Ana Maria; Llado, Isabel] Univ Illes Baleares, Inst Univ Invest Ciencies Salut IUNICS, Dept Biol Fonamental & Ciencies Salut, Grup Metab Energet & Nutr GMEIN, Ctra Valldemossa Km 7-5, E-07122 Palma De Mallorca, Balearic Island, Spain.
   [Moran-Costoya, Andrea; Amengual-Cladera, Emilia; Valle, Adamo; Proenza, Ana Maria; Llado, Isabel] Hosp Univ Son Espases, Inst Invest Sanitaria Illes Baleares IdISBa, E-07120 Palma De Mallorca, Balearic Island, Spain.
   [Valle, Adamo; Proenza, Ana Maria; Llado, Isabel] Inst Salud Carlos III, Ctr Invest Biomed Red Fisiopatol Obesidad & Nutr C, CB06-03-0043, E-28029 Madrid, Spain.
C3 Universitat de les Illes Balears; IUNICS; Hospital Universitari Son
   Espases; Instituto de Salud Carlos III
RP Proenza, AM (corresponding author), Univ Illes Baleares, Inst Univ Invest Ciencies Salut IUNICS, Dept Biol Fonamental & Ciencies Salut, Grup Metab Energet & Nutr GMEIN, Ctra Valldemossa Km 7-5, E-07122 Palma De Mallorca, Balearic Island, Spain.
EM ana.proenza@uib.es
RI Proenza, Ana/L-3383-2014; Valle, Adamo/H-7042-2017; Morán-Costoya,
   Andrea/HGC-4729-2022; Amengual-Cladera, Emilia/JZS-9806-2024;
   Amengual-Cladera, Emilia/E-8667-2018
OI Amengual-Cladera, Emilia/0000-0003-4795-316X; Moran Costoya,
   Andrea/0000-0003-1219-6832; Martinez-Cignoni, Melanie
   Raquel/0000-0002-3469-7980
FU Ministry of Science, Innovation and Universities [SAF2016-80384 R]; ERDF
   A way of making Europe of the Spanish Government - Balearic Islands
   Government; Balearic Islands Government [FPI/1888/2016, FPI/043/2021];
   European Social Fund; Garantia Juvenil SOIB
FX This work was supported by the Ministry of Science, Innovation and
   Universities (grant number SAF2016-80384 R) and by "ERDF A way of making
   Europe" of the Spanish Government. M.R.M.-C. and A.M.-C were funded by
   the Balearic Islands Government (FPI/1888/2016; FPI/043/2021) , after
   being selected in the framework on an operating program co-financed by
   the European Social Fund. A.G.-V. was funded by a contract from Garantia
   Juvenil SOIB co-financed by European Social Fund.
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NR 61
TC 3
Z9 3
U1 2
U2 3
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0891-5849
EI 1873-4596
J9 FREE RADICAL BIO MED
JI Free Radic. Biol. Med.
PD NOV 1
PY 2024
VL 224
BP 574
EP 587
DI 10.1016/j.freeradbiomed.2024.09.001
EA SEP 2024
PG 14
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA G7M7B
UT WOS:001318438800001
PM 39241985
OA hybrid
DA 2025-06-11
ER

PT J
AU Ceyhan, B
   Nategh, P
   Neghabi, M
   Lamar, JA
   Konjalwar, S
   Rodriguez, P
   Hahn, MK
   Gross, M
   Grumbar, G
   Salleng, KJ
   Blakely, RD
   Ranji, M
AF Ceyhan, Busenur
   Nategh, Parisa
   Neghabi, Mehrnoosh
   Lamar, Jacob A.
   Konjalwar, Shalaka
   Rodriguez, Peter
   Hahn, Maureen K.
   Gross, Matthew
   Grumbar, Gregory
   Salleng, Kenneth J.
   Blakely, Randy D.
   Ranji, Mahsa
TI Optical Imaging Demonstrates Tissue-Specific Metabolic Perturbations in
   Mblac1 Knockout Mice
SO IEEE JOURNAL OF TRANSLATIONAL ENGINEERING IN HEALTH AND MEDICINE
LA English
DT Article
DE MBLAC1; Alzheimer's disease; optical metabolic imaging; redox state;
   metabolic syndrome
ID ALZHEIMERS-DISEASE; CAENORHABDITIS-ELEGANS; MITOCHONDRIAL REDOX;
   FLUORESCENCE; STRESS; BRAIN; NADH; DYSFUNCTION; MECHANISMS; EXPRESSION
AB Objective: Metabolic changes have been extensively documented in neurodegenerative brain disorders, including Parkinson's disease and Alzheimer's disease (AD). Mutations in the C. elegans swip-10 gene result in dopamine (DA) dependent motor dysfunction accompanied by DA neuron degeneration. Recently, the putative human ortholog of swip-10 (MBLAC1) was implicated as a risk factor in AD, a disorder that, like PD, has been associated with mitochondrial dysfunction. Interestingly, the AD risk associated with MBLAC1 arises in subjects with cardiovascular morbidity, suggesting a broader functional insult arising from reduced MBLAC1 protein expression and one possibly linked to metabolic alterations. Methods: Our current studies, utilizing Mblac1 knockout (KO) mice, seek to determine whether mitochondrial respiration is affected in the peripheral tissues of these mice. We quantified the levels of mitochondrial coenzymes, NADH, FAD, and their redox ratio (NADH/FAD, RR) in livers and kidneys of wild-type (WT) mice and their homozygous KO littermates of males and females, using 3D optical cryo-imaging. Results: Compared to WT, the RR of livers from KO mice was significantly reduced, without an apparent sex effect, driven predominantly by significantly lower NADH levels. In contrast, no genotype and sex differences were observed in kidney samples. Serum analyses of WT and KO mice revealed significantly elevated glucose levels in young and aged KO adults and diminished cholesterol levels in the aged KOs, consistent with liver dysfunction. Discussion/Conclusion: As seen with C. elegans swip-10 mutants, loss of MBLAC1 protein results in metabolic changes that are not restricted to neural cells and are consistent with the presence of peripheral comorbidities accompanying neurodegenerative disease in cases where MBLAC1 expression changes impact risk.
C1 [Ceyhan, Busenur; Nategh, Parisa; Neghabi, Mehrnoosh; Konjalwar, Shalaka; Ranji, Mahsa] Florida Atlantic Univ, Coll Engn & Comp Sci, Dept Elect Engn & Comp Sci, Biophoton Lab, Boca Raton, FL 33431 USA.
   [Lamar, Jacob A.; Rodriguez, Peter; Hahn, Maureen K.; Gross, Matthew; Grumbar, Gregory; Blakely, Randy D.] Florida Atlantic Univ, Charles E Schmidt Coll Med, Dept Biomed Sci, Boca Raton, FL 33431 USA.
   [Hahn, Maureen K.; Blakely, Randy D.; Ranji, Mahsa] Florida Atlantic Univ, Tiles Nicholson Brain Inst, Jupiter, FL 33458 USA.
   [Salleng, Kenneth J.] Florida Atlantic Univ, Div Res Comparat Med, Boca Raton, FL 33431 USA.
C3 State University System of Florida; Florida Atlantic University; State
   University System of Florida; Florida Atlantic University; State
   University System of Florida; Florida Atlantic University; State
   University System of Florida; Florida Atlantic University
RP Ranji, M (corresponding author), Florida Atlantic Univ, Coll Engn & Comp Sci, Dept Elect Engn & Comp Sci, Biophoton Lab, Boca Raton, FL 33431 USA.; Blakely, RD (corresponding author), Florida Atlantic Univ, Charles E Schmidt Coll Med, Dept Biomed Sci, Boca Raton, FL 33431 USA.; Blakely, RD; Ranji, M (corresponding author), Florida Atlantic Univ, Tiles Nicholson Brain Inst, Jupiter, FL 33458 USA.
EM rblakely@health.fau.edu; mranji@fau.edu
RI Neghabi, Mehrnoosh/KHY-8125-2024; Nategh, Parisa/HNI-6011-2023
OI Neghabi, Mehrnoosh/0000-0003-1256-4770; Grumbar,
   Gregory/0000-0002-9746-8763; Nategh, Parisa/0009-0009-2974-7742; Ceyhan,
   Busenur/0009-0001-8549-2846; Rodriguez, Peter/0000-0002-4331-8516
FU NIH Award
FX No Statement Available
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NR 64
TC 2
Z9 3
U1 2
U2 6
PU IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
PI PISCATAWAY
PA 445 HOES LANE, PISCATAWAY, NJ 08855-4141 USA
SN 2168-2372
J9 IEEE J TRANSL ENG HE
JI IEEE J. Transl. Eng. Health Med.-JTEHM
PY 2024
VL 12
BP 298
EP 305
DI 10.1109/JTEHM.2024.3355962
PG 8
WC Engineering, Biomedical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering
GA IB8K5
UT WOS:001163952300001
PM 38410184
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Wang, XL
   Wang, YY
   Tang, T
   Zhao, GW
   Dong, W
   Li, QX
   Liang, XL
AF Wang, Xinli
   Wang, Yanyan
   Tang, Tao
   Zhao, Guowei
   Dong, Wei
   Li, Qiuxiang
   Liang, Xinli
TI Curcumin-Loaded RH60/F127 Mixed Micelles: Characterization,
   Biopharmaceutical Characters and Anti-Inflammatory Modulation of Airway
   Inflammation
SO PHARMACEUTICS
LA English
DT Article
DE curcumin; nanomicelles; bioavailability; airway inflammation
ID MACROPHAGE POLARIZATION; OXIDATIVE STRESS; DELIVERY; ASTHMA; DRUG;
   NANOPARTICLES; STRATEGY; EFFICACY; MODEL; RATS
AB Curcumin's ability to impact chronic inflammatory conditions, such as metabolic syndrome and arthritis, has been widely researched; however, its poor bioavailability limits its clinical application. The present study is focused on the development of curcumin-loaded polymeric nanomicelles as a drug delivery system with anti-inflammatory effects. Curcumin was loaded in PEG-60 hydrogenated castor oil and puronic F127 mixed nanomicelles (Cur-RH60/F127-MMs). Cur-RH60/F127-MMs was prepared using the thin film dispersion method. The morphology and releasing characteristics of nanomicelles were evaluated. The uptake and permeability of Cur-RH60/F127-MMs were investigated using RAW264.7 and Caco-2 cells, and their bioavailability and in vivo/vitro anti-inflammatory activity were also evaluated. The results showed that Cur-RH60/F127-MMs have regular sphericity, possess an average diameter smaller than 20 nm, and high encapsulation efficiency for curcumin (89.43%). Cur-RH60/F127-MMs significantly increased the cumulative release of curcumin in vitro and uptake by cells (p < 0.01). The oral bioavailability of Cur-RH60/F127-MMs was much higher than that of curcumin-active pharmaceutical ingredients (Cur-API) (about 9.24-fold). The treatment of cell lines with Cur-RH60/F127-MMs exerted a significantly stronger anti-inflammatory effect compared to Cur-API. In addition, Cur-RH60/F127-MMs significantly reduced OVA-induced airway hyperresponsiveness and inflammation in an in vivo experimental asthma model. In conclusion, this study reveals the possibility of formulating a new drug delivery system for curcumin, in particular nanosized micellar aqueous dispersion, which could be considered a perspective platform for the application of curcumin in inflammatory diseases of the airways.
C1 [Wang, Xinli; Zhao, Guowei; Dong, Wei; Li, Qiuxiang; Liang, Xinli] Jiangxi Univ Chinese Med, Key Lab Modern Preparat TCM, Minist Educ, Nanchang 330004, Peoples R China.
   [Wang, Xinli] Jiangxi Med Device Testing Ctr, Nanchang 330029, Peoples R China.
   [Wang, Yanyan] Jiangxi Univ Chinese Med, Clin Med Sch, Nanchang 330004, Peoples R China.
   [Tang, Tao] Jian Cent Peoples Hosp, Dept Pharm, Jian 343000, Peoples R China.
C3 Jiangxi University of Traditional Chinese Medicine; Ministry of
   Education - China; Jiangxi University of Traditional Chinese Medicine
RP Liang, XL (corresponding author), Jiangxi Univ Chinese Med, Key Lab Modern Preparat TCM, Minist Educ, Nanchang 330004, Peoples R China.
EM sofia13ts@gmail.com; guyuan97@163.com; marryrose1013@163.com;
   weiweihaoyunqi@163.com; sober96@foxmail.com; liqiuxiang76@163.com;
   paln7@163.com
RI Tang, Tao/I-1944-2012; dong, wei/KVA-6898-2024
OI liang, xinli/0000-0001-8644-2886
FU National Natural Science Foundation of China; Key Laboratory of Modern
   Preparation of TCM, Ministry of Education, Jiangxi University of Chinese
   Medicine
FX The authors gratefully acknowledge the support for this research from
   the Key Laboratory of Modern Preparation of TCM, Ministry of Education,
   Jiangxi University of Chinese Medicine.
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NR 63
TC 2
Z9 2
U1 0
U2 7
PU MDPI
PI BASEL
PA Gross-peteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 1999-4923
J9 PHARMACEUTICS
JI Pharmaceutics
PD DEC
PY 2023
VL 15
IS 12
AR 2710
DI 10.3390/pharmaceutics15122710
PG 18
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA DN7Y9
UT WOS:001132806200001
PM 38140051
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Nyakundi, BB
   Yang, JZ
AF Nyakundi, Benard B.
   Yang, Jinzeng
TI Uses of Papaya Leaf and Seaweed Supplementations for Controlling Glucose
   Homeostasis in Diabetes
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE bioactive compound; diabetes; hyperglycemia; seaweed; Carica papaya;
   type 2 diabetes; insulin resistance; herbs; secondary metabolites;
   natural products; glucose uptake
ID ALPHA-AMYLASE INHIBITOR; DE-NOVO LIPOGENESIS; CARICA-PAPAYA; OXIDATIVE
   STRESS; SKELETAL-MUSCLE; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   POSTPRANDIAL HYPERGLYCEMIA; BENZYL ISOTHIOCYANATE; GLUT4 TRANSLOCATION
AB Studies from laboratory animal models and complementary medical practices have implied that nutrients from special plants or herbs contain antidiabetic, antioxidant, anti-obese, anti-hypertensive, and anti-inflammatory properties. Seaweed and tropical papaya, which are widely available in Asian and Pacific countries, have been used as home remedies for centuries. The bioactive extracts from these plants contain vitamins A, C, B and E complexes, as well as polysaccharides, phenolic compounds, essential fatty acids, flavonoids, saponins, fucoidan, and phlorotannin. In this review, the authors examine the pathogenesis of diabetes characterized by hyperglycemia due to the dysregulation of glucose homeostasis, antidiabetic/antihyperglycemic seaweed or/and papaya derived bioactive phytochemicals and their proposed mechanisms of action in the management of Type 2 Diabetes Mellitus (T2DM). The authors also propose combining papaya and seaweed to enhance their antidiabetic effects, leveraging the advantages of herb-to-herb combination. Papaya and seaweed have demonstrated antidiabetic effects through in vitro assays, cellular models, and animal studies despite the limited clinical trials. Nutraceuticals with antidiabetic effects, such as secondary metabolites isolated from seaweed and papaya, could be combined for a synergistic effect on T2DM management. However, the application of these compounds in their purified or mixed forms require further scientific studies to evaluate their efficacy against diabetes-related complications, such as hyperlipidemia, elevated free radicals, pro-inflammatory molecules, insulin insensitivity, and the degeneration of pancreatic beta cells.
C1 [Nyakundi, Benard B.; Yang, Jinzeng] Univ Hawaii Manoa, Dept Human Nutr Food & Anim Sci, Honolulu, HI 96822 USA.
C3 University of Hawaii System; University of Hawaii Manoa
RP Yang, JZ (corresponding author), Univ Hawaii Manoa, Dept Human Nutr Food & Anim Sci, Honolulu, HI 96822 USA.
EM jinzeng@hawaii.edu
OI Yang, Jinzeng/0000-0002-2483-4734; Nyakundi, Benard/0009-0002-4593-2437
FU USDA [W4002]
FX The fundings for this research program are from the USDA multi-state
   project-Nutrient Bioavailability-Phytonutrients and Beyond (W4002),
   administrated by the College of Tropical Agriculture and Human Resources
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NR 114
TC 6
Z9 6
U1 3
U2 16
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD APR
PY 2023
VL 24
IS 7
AR 6846
DI 10.3390/ijms24076846
PG 15
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA D7DB7
UT WOS:000970284600001
PM 37047820
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Asaoka, R
   Obana, A
   Murata, H
   Fujino, Y
   Omoto, T
   Aoki, S
   Muto, S
   Takayanagi, Y
   Inoue, T
   Tanito, M
AF Asaoka, Ryo
   Obana, Akira
   Murata, Hiroshi
   Fujino, Yuri
   Omoto, Takashi
   Aoki, Shuichiro
   Muto, Shigetaka
   Takayanagi, Yuji
   Inoue, Tatsuya
   Tanito, Masaki
TI The Association Between Age and Systemic Variables and the Longitudinal
   Trend of Intraocular Pressure in a Large-Scale Health Examination Cohort
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Article
DE intraocular pressure; health examination cohort
ID TRABECULAR MESHWORK; AQUEOUS-HUMOR; METABOLIC SYNDROME; OXIDATIVE
   STRESS; OPEN-ANGLE; EXTRACELLULAR-MATRIX; INSULIN-RESISTANCE; REFRACTIVE
   ERRORS; RISK-FACTORS; GLAUCOMA
AB PURPOSE. The detailed effects of age and systemic factors on intraocular pressure (IOP) have not been fully understood because of the lack of a large-scale longitudinal investigation. This study aimed to investigate the effect of various systemic factors on the longitudinal change of IOP.
   METHODS. There were a total of 20,909 eyes of 10,471 subjects from a health checkup cohort that were followed up for systemic factors: (i) age at baseline, (ii) sex, (iii) time series body mass index (BMI), (iv) time series smoking habits, (v) time series systolic and diastolic blood pressures (SBP and DBP), and (vi) time series 19 blood examinations (all of the time series data was acquired at each annual visit), along with IOP annually for at least 8 years. Then the longitudinal effect of the systemic factors on the change of IOP was investigated.
   RESULTS. IOP significantly decreased by -0.084 mm Hg/year. BMI, SBP, DBP, smoking habits, total triglyceride, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and glycosylated hemoglobin A1c were not significantly associated with the change of IOP. Higher values of age, aspartate aminotransferase, hemoglobin, platelet, and calcium were suggested to be significantly associated with the decrease of IOP, whereas higher alanine aminotransferase, guanosine triphosphate, white blood cell count, red blood cell count, and female gender were significantly associated with the increase of IOP.
   CONCLUSIONS. Age, aspartate aminotransferase, hemoglobin, platelet, calcium, alanine aminotransferase, guanosine triphosphate, white blood cell count, red blood cell count, and gender were the systemic variables significantly associated with the change of IOP.
C1 [Asaoka, Ryo; Obana, Akira; Fujino, Yuri; Takayanagi, Yuji] Seirei Hamamatsu Gen Hosp, Dept Ophthalmol, Hamamatsu, Shizuoka, Japan.
   [Asaoka, Ryo] Seirei Christopher Univ, Hamamatsu, Shizuoka, Japan.
   [Asaoka, Ryo; Murata, Hiroshi; Omoto, Takashi] Univ Tokyo, Dept Ophthalmol, Tokyo, Japan.
   [Asaoka, Ryo] Shizuoka Univ, Res Inst Elect, Nanovis Res Div, Shizuoka, Japan.
   [Asaoka, Ryo] Grad Sch Creat New Photon Ind, Shizuoka, Japan.
   [Obana, Akira] Hamamatsu Univ Sch Med, Preeminent Med Photon Educ & Res Ctr, Inst Med Photon Res, Hamamatsu BioPhoton Innovat Chair, Shizuoka, Japan.
   [Murata, Hiroshi] Natl Ctr Global Hlth & Med, Dept Ophthalmol, Shinjuku Ku, Tokyo, Japan.
   [Fujino, Yuri; Takayanagi, Yuji; Tanito, Masaki] Shimane Univ, Dept Ophthalmol, Fac Med, Izumo, Shimane, Japan.
   [Aoki, Shuichiro] Sapporo City Gen Hosp, Dept Ophthalmol, Sapporo, Hokkaido, Japan.
   [Muto, Shigetaka] Seirei Ctr Hlth Promot & Prevent Med, Hamamatsu, Shizuoka, Japan.
   [Inoue, Tatsuya] Yokohama City Univ, Dept Ophthalmol & Microtechnol, Yokohama, Kanagawa, Japan.
C3 University of Tokyo; Shizuoka University; Hamamatsu University School of
   Medicine; Japan Institute for Health Security (JIHS); National Center
   for Global Health & Medicine - Japan; Shimane University; Sapporo City
   General Hospital; Yokohama City University
RP Asaoka, R (corresponding author), Seirei Hamamatsu Gen Hosp, Dept Ophthalmol, Naka Ku, 2-12-12 Sumiyoshi, Hamamatsu, Shizuoka, Japan.
EM rasaoka-tky@umin.ac.jp
FU Ministry of Education, Culture, Sports, Science and Technology of Japan
   [19H01114, 18KK0253, 20K09784, 20768254, 80635748]; Japan Agency for
   Medical Research and Development (AMED); AIP acceleration research from
   the Japan Science and Technology Agency; Grants-in-Aid for Scientific
   Research [20K09785] Funding Source: KAKEN
FX Supported by Grants (nos. 19H01114: to R.A., 18KK0253: to R.A.,
   20K09784: to R.A., 20768254: to Y.F., and 80635748: to H.M.) from the
   Ministry of Education, Culture, Sports, Science and Technology of Japan
   (R.A., F.Y., and H.M.), and the Translational Research Program;
   Strategic Promotion for Practical Application of Innovative Medical
   Technology (TR-SPRINT) from the Japan Agency for Medical Research and
   Development (AMED) (to R.A.), and grant AIP acceleration research from
   the Japan Science and Technology Agency (to R.A.).
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NR 77
TC 13
Z9 13
U1 0
U2 4
PU ASSOC RESEARCH VISION OPHTHALMOLOGY INC
PI ROCKVILLE
PA 12300 TWINBROOK PARKWAY, ROCKVILLE, MD 20852-1606 USA
SN 0146-0404
EI 1552-5783
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD OCT
PY 2022
VL 63
IS 11
DI 10.1167/iovs.63.11.22
PG 7
WC Ophthalmology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Ophthalmology
GA 8U1GP
UT WOS:000929699600017
PM 36301531
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Ilyas, A
   Wijayasinghe, YS
   Khan, I
   El Samaloty, NM
   Adnan, M
   Dar, TA
   Poddar, NK
   Singh, LR
   Sharma, H
   Khan, S
AF Ilyas, Ashal
   Wijayasinghe, Yasanandana Supunsiri
   Khan, Ilyas
   El Samaloty, Nourhan M.
   Adnan, Mohd
   Dar, Tanveer Ali
   Poddar, Nitesh Kumar
   Singh, Laishram R.
   Sharma, Hemlata
   Khan, Shahanavaj
TI Implications of trimethylamine N-oxide (TMAO) and Betaine in Human
   Health: Beyond Being Osmoprotective Compounds
SO FRONTIERS IN MOLECULAR BIOSCIENCES
LA English
DT Review
DE osmolytes; chemical chaperones; TMAO; betaine; choline; cardiovascular
   disease; liver disease
ID PLASMA HOMOCYSTEINE CONCENTRATIONS; NONALCOHOLIC FATTY LIVER; NLRP3
   INFLAMMASOME ACTIVATION; ENDOPLASMIC-RETICULUM STRESS; HEPATIC
   INSULIN-RESISTANCE; CONTAINING MONOOXYGENASE 3; ORGANIC OSMOLYTES;
   GLYCINE BETAINE; ELEVATED LEVELS; METHIONINE METABOLISM
AB Osmolytes are naturally occurring small molecular weight organic molecules, which are accumulated in large amounts in all life forms to maintain the stability of cellular proteins and hence preserve their functions during adverse environmental conditions. Trimethylamine N-oxide (TMAO) and N,N,N-trimethylglycine (betaine) are methylamine osmolytes that have been extensively studied for their diverse roles in humans and have demonstrated opposing relations with human health. These osmolytes are obtained from food and synthesized endogenously using dietary constituents like choline and carnitine. Especially, gut microbiota plays a vital role in TMAO synthesis and contributes significantly to plasma TMAO levels. The elevated plasma TMAO has been reported to be correlated with the pathogenesis of numerous human diseases, including cardiovascular disease, heart failure, kidney diseases, metabolic syndrome, etc.; Hence, TMAO has been recognized as a novel biomarker for the detection/prediction of several human diseases. In contrast, betaine acts as a methyl donor in one-carbon metabolism, maintains cellular S-adenosylmethionine levels, and protects the cells from the harmful effects of increased plasma homocysteine. Betaine also demonstrates antioxidant and anti-inflammatory activities and has a promising therapeutic value in several human diseases, including homocystinuria and fatty liver disease. The present review examines the multifarious functions of TMAO and betaine with possible molecular mechanisms towards a better understanding of their emerging and diverging functions with probable implications in the prevention, diagnosis, and treatment of human diseases.
C1 [Ilyas, Ashal] Invertis Univ, Dept Biotechnol, Bareilly, Uttar Pradesh, India.
   [Wijayasinghe, Yasanandana Supunsiri] Univ Kelaniya, Fac Med, Dept Biochem & Clin Chem, Ragama, Sri Lanka.
   [Khan, Ilyas] Majmaah Univ, Coll Sci Al Zulfi, Dept Math, Al Majmaah, Saudi Arabia.
   [El Samaloty, Nourhan M.] Future Univ Egypt, Fac Pharm, Dept Pharmacol Toxicol & Biochem, Cairo, Egypt.
   [Adnan, Mohd] Univ Hail, Coll Sci, Dept Biol, Hail, Saudi Arabia.
   [Dar, Tanveer Ali] Univ Kashmir, Dept Clin Biochem, Srinagar, Jammu And Kashm, India.
   [Poddar, Nitesh Kumar; Sharma, Hemlata] Manipal Univ Jaipur, Dept Biosci, Jaipur, Rajasthan, India.
   [Singh, Laishram R.] Univ Delhi, Dr BR Ambedkar Ctr Biomed Res, Delhi, India.
   [Khan, Shahanavaj] King Saud Univ, Coll Pharm, Dept Pharmaceut, Riyadh, Saudi Arabia.
   [Khan, Shahanavaj] Indian Inst Hlth & Technol IIHT, Dept Med Lab Technol, Saharanpur, Uttar Pradesh, India.
C3 Invertis University; University Kelaniya; Majmaah University; Egyptian
   Knowledge Bank (EKB); Future University in Egypt; University Ha'il;
   University of Kashmir; Manipal University Jaipur; University of Delhi;
   King Saud University
RP Wijayasinghe, YS (corresponding author), Univ Kelaniya, Fac Med, Dept Biochem & Clin Chem, Ragama, Sri Lanka.; Poddar, NK (corresponding author), Manipal Univ Jaipur, Dept Biosci, Jaipur, Rajasthan, India.; Khan, S (corresponding author), King Saud Univ, Coll Pharm, Dept Pharmaceut, Riyadh, Saudi Arabia.; Khan, S (corresponding author), Indian Inst Hlth & Technol IIHT, Dept Med Lab Technol, Saharanpur, Uttar Pradesh, India.
EM supunw@kln.ac.lk; niteshpoddar@gmail.com;
   niteshkumar.poddar@jaipur.manipal.edu
RI Khan, Shahanavaj/F-1032-2019; Dar, Tanveer/F-3738-2019; Wijayasinghe,
   Yasanandana/CAF-8224-2022; poddar, nitesh/AAD-9130-2022; Adnan,
   Mohd/N-9207-2015
OI Wijayasinghe, Yasanandana/0000-0002-1269-6397; Adnan,
   Mohd/0000-0002-7080-6822; Khan, Shahanavaj/0000-0002-4049-2244
FU Research Center, College of Science Al-Zulfi, Majmaah University,
   Al-Majmaah 11952, Saudi Arabia;  [EF/2019-20/QE04-02]
FX The current work is supported by the Research Center, College of Science
   Al-Zulfi, Majmaah University, Al-Majmaah 11952, Saudi Arabia.
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NR 192
TC 34
Z9 35
U1 3
U2 22
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 2296-889X
J9 FRONT MOL BIOSCI
JI Front. Mol. Biosci.
PD AUG 26
PY 2022
VL 9
AR 1014120
DI 10.3389/fmolb.2022.964624
PG 21
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 5U7RI
UT WOS:000876739900001
PM 36310589
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Lee, W
   Jung, J
   Ahn, J
   Kim, HR
AF Lee, Wanhyung
   Jung, Jiyoun
   Ahn, Joonho
   Kim, Hyoung-Ryoul
TI Rate of inappropriate energy and micronutrient intake among the Korean
   working population
SO PUBLIC HEALTH NUTRITION
LA English
DT Article
DE Nutrition; Energy; Workers; Korean National Health and Nutritional
   Examination Survey
ID SHIFT WORK; METABOLIC SYNDROME; NATIONAL-HEALTH; METAANALYSIS;
   NUTRITION; OBESITY; STRESS; OUTCOMES; ADULTS; RISK
AB Objective:
   Adequate energy and nutrient intakes are important for workers who spend at least one-third of their day working. We investigated differences in these intakes among Korean workers because few studies have reported on energy or nutrient intakes, related to working conditions (long working hours, shift work and non-standard work).
   Design:
   Dietary intake was assessed using 1-d 24-h recall. Energy and nutrient intakes were evaluated using age- and sex-specific dietary reference intakes for Korean citizens. Occupational characteristics were obtained from self-reported Korean National Health and Nutritional Examination Survey (KNHANES) data (occupational classification, working hours, shift work and non-standard workers). An age, education and household income-adjusted logistic regression model was applied to investigate differences in inappropriate energy and nutrient intakes, by sex and occupation.
   Setting:
   Cross-sectional study.
   Participants:
   From KNHANES (2007-2016), 11 145 participants (5401 males; 5744 females) were included, finally.
   Results:
   Males with long working hours had higher inappropriate carbohydrate, protein, water, vitamin B2 and phosphate intakes than those who worked <= 60 h/week. Long working hours among females were significantly associated with total energy and nutrient 'under-intake'. Male shift and non-standard workers had higher inappropriate protein, water, mineral and vitamin intakes. Multivariate logistic regression revealed that white- and male pink-collar workers had significantly increased risks of water and vitamins A, C, B-1 and niacin 'under-intake'.
   Conclusions:
   We found different rates of inappropriate energy and micronutrient intakes according to working conditions. Younger workers with long hours and shift work schedules were vulnerable to inappropriate energy and nutrient intakes.
C1 [Lee, Wanhyung] Gachon Univ, Coll Med, Gil Med Ctr, Dept Occupat & Environm Med, Incheon, South Korea.
   [Jung, Jiyoun; Ahn, Joonho; Kim, Hyoung-Ryoul] Catholic Univ Korea, Seoul St Marys Hosp, Coll Med, Dept Occupat & Environm Med, Seoul, South Korea.
C3 Gachon University; Seoul St. Mary's Hospital; Catholic University of
   Korea
RP Kim, HR (corresponding author), Catholic Univ Korea, Seoul St Marys Hosp, Coll Med, Dept Occupat & Environm Med, Seoul, South Korea.
EM cyclor@catholic.ac.kr
RI Lee, Wanhyung/M-8739-2016; Kim, Hyungduk/CAH-5630-2022
OI Ahn, Joonho/0000-0002-5940-9877
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   2014, REG ANESTH PAIN MED, V9
NR 32
TC 4
Z9 4
U1 0
U2 6
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 1368-9800
EI 1475-2727
J9 PUBLIC HEALTH NUTR
JI Public Health Nutr.
PD DEC
PY 2020
VL 23
IS 18
BP 3356
EP 3367
AR PII S1368980019004075
DI 10.1017/S1368980019004075
PG 12
WC Public, Environmental & Occupational Health; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health; Nutrition & Dietetics
GA PE5KX
UT WOS:000598405600013
PM 32183914
OA Green Published
DA 2025-06-11
ER

PT J
AU Gerges, SH
   Wahdan, SA
   Elsherbiny, DA
   El-Demerdash, E
AF Gerges, Samar H.
   Wahdan, Sara A.
   Elsherbiny, Doaa A.
   El-Demerdash, Ebtehal
TI Diosmin ameliorates inflammation, insulin resistance, and fibrosis in an
   experimental model of non-alcoholic steatohepatitis in rats
SO TOXICOLOGY AND APPLIED PHARMACOLOGY
LA English
DT Article
DE Diosmin; Non-alcoholic Steatohepatitis; High-Fat Diet; Streptozotocin;
   Fibrosis; Insulin Resistance
ID FATTY LIVER-DISEASE; NECROSIS-FACTOR-ALPHA; METABOLIC SYNDROME;
   HEPATIC-FIBROSIS; OXIDATIVE STRESS; ADIPONECTIN; NASH; OBESITY; CELLS;
   MICE
AB Non-alcoholic steatohepatitis (NASH) is becoming of increasing significance due to its growing global prevalence and risk of progression to end-stage liver disease. This study was carried out to investigate the potential anti-inflammatory, insulin sensitizing, and antifibrotic effects of diosmin in an experimental model of NASH induced in rats using high-fat diet (HFD) and 30 mg/kg streptozotocin (STZ). Diosmin was administered orally at dose of 100 mg/kg for 8 weeks. Stained tissue sections were examined for histopathological signs of NASH, collagen deposition, and alpha smooth muscle actin (alpha-SMA) expression. In addition, insulin resistance, dyslipidemia, inflammation, and fibrosis markers were assessed. HFD/STZ successfully induced different NASH features such as insulin resistance seen by elevated fasting blood glucose levels and homeostasis model assessment for insulin resistance. Moreover, induced rats demonstrated dyslipidemia, a significant elevation in tumor necrosis factor alpha (TNF-alpha) and interleukin-6 levels, and an imbalance in the oxidative status of the liver. Those events altogether precipitated initiation of liver fibrosis as confirmed by elevated transforming growth factor beta (TGF-beta) levels. Treatment with diosmin demonstrated multiple beneficial effects as it significantly ameliorated histopathological NASH findings, lowered TNF-alpha, interleukin-6, and malondialdehyde levels, improved lipid and glucose metabolism, and lowered hepatic TGF-beta, alpha-SMA, and collagen content compared to untreated rats. The present study represents a drug repositioning scenario as diosmin is widely used for management of blood vessel disorders and is known to be well tolerated. This encourages the extension of our study to the clinical setting to explore diosmin effects in NASH patients.
C1 [Gerges, Samar H.; Wahdan, Sara A.; Elsherbiny, Doaa A.; El-Demerdash, Ebtehal] Ain Shams Univ, Fac Pharm, Dept Pharmacol & Toxicol, Org African Unity St, Cairo 11566, Egypt.
C3 Egyptian Knowledge Bank (EKB); Ain Shams University
RP El-Demerdash, E (corresponding author), Ain Shams Univ, Fac Pharm, Dept Pharmacol & Toxicol, Org African Unity St, Cairo 11566, Egypt.
EM ebtehal_dm@pharma.asu.edu.eg
RI El-Demerdash, Ebtehal/ABE-6729-2020
OI Nesr (Gerges), Samar/0000-0003-0450-0056
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NR 68
TC 29
Z9 29
U1 1
U2 13
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0041-008X
EI 1096-0333
J9 TOXICOL APPL PHARM
JI Toxicol. Appl. Pharmacol.
PD AUG 15
PY 2020
VL 401
AR 115101
DI 10.1016/j.taap.2020.115101
PG 11
WC Pharmacology & Pharmacy; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Toxicology
GA MO4QK
UT WOS:000551512500014
PM 32512072
DA 2025-06-11
ER

PT J
AU Iddrisu, MA
   Senadjki, A
   Spr, CR
   Yong, HNA
   Yew, KT
   Poulsaeman, V
AF Iddrisu, Mohammed Awal
   Senadjki, Abdelhak
   Spr, Charles Ramendran
   Yong, Hui Nee Au
   Yew, King Tak
   Poulsaeman, Veronica
TI Factors of Health Promotion Behaviour (HPB) and Elderly Health Diseases
   in Malaysia
SO JOURNAL OF POPULATION AGEING
LA English
DT Article
DE Health promotion behaviour (HPB); Healthy eating; Elderly health
   diseases; Health responsibility; Exercise
ID PHYSICAL INACTIVITY; METABOLIC SYNDROME; OLDER-ADULTS; RISK-FACTORS;
   PLS-SEM; MANAGEMENT; CARE; POPULATION; EDUCATION; RESPONSIBILITY
AB In Malaysia, the fast decline in fertility and increase in longevity (due to better health care and improved living conditions) have contributed to a rapid aging population growth. The lack of Health promotion behaviours, healthcare knowledge and awareness among the elderly has led to the increase of Non-communicable diseases (NCDs) (such as Diabetes Mellitus, Hypertension, Hypercholesterolemia, Minor Stroke, Kidney Failure and Heart Problem). These illnesses have killed over 1000 elderly people over the years, and the number has significantly increased. Despite several initiatives taken by the government to tackle the issues, a large group of elderly are yet to benefit from the health campaign. Since the aging population is expected to rise in the future, it equally significant for the government to prepare proper measure to tackle the phenomenon in the coming years. This study, therefore, is to investigate the effect of factors of HPB on elderly health disease in Malaysia. The factors of HPB are measured in 6 aspects, namely, healthy eating, exercise, stress management, interpersonal relations, health responsibility and spiritual growth. A set of 520 survey questionnaires was distributed and collected from respondents located in Perak, Malacca, Penang and Selangor. The statistical analysis result is analysed by using SmartPLS Software 3.0. The data analysis implicated that, elderly health disease is significantly affected by the factors of HPB (healthy eating, exercise, Interpersonal relationship and health responsibility). Therefore, findings suggest that adequate policies for HPB programs is necessary to encourage the practices of healthy eating, exercise, good interpersonal relationship and health responsibility, among the elderly.
C1 [Iddrisu, Mohammed Awal; Senadjki, Abdelhak; Spr, Charles Ramendran; Yong, Hui Nee Au; Yew, King Tak; Poulsaeman, Veronica] Univ Tunku Abdul Rahman, Fac Business & Finance, Petaling Jaya, Malaysia.
C3 Universiti Tunku Abdul Rahman (UTAR)
RP Iddrisu, MA (corresponding author), Univ Tunku Abdul Rahman, Fac Business & Finance, Petaling Jaya, Malaysia.
EM awaaal40@gmail.com; abdelhak@utar.edu.my; charlesr@utar.edu.my;
   auyonghn@utar.edu.my; yewkt@utar.edu.my; veronica@utar.edu.my
RI Ramendran, Charles/AAM-8152-2021; poulsaeman, veronica/AAB-8428-2021;
   Abdelhak, Senadjki/A-8476-2013; Au Yong, Hui Nee/S-8351-2017
OI Abdelhak, Senadjki/0000-0002-4302-4091; Iddrisu, Mohammed
   Awal/0000-0001-5049-4254; Au Yong, Hui Nee/0000-0002-3337-213X
FU UTAR grant [IPRS/RMC/UTARRF/2017-C2/AO1]; USM grant: RU Top Down
   Research Grant [1001/PSOSIAL/807001]
FX This research is funded by UTAR grant: IPRS/RMC/UTARRF/2017-C2/AO1 and
   USM grant: RU Top Down Research Grant 1001/PSOSIAL/807001.
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NR 119
TC 4
Z9 4
U1 0
U2 18
PU SPRINGER INT PUBL AG
PI CHAM
PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND
SN 1874-7884
EI 1874-7876
J9 J POPUL AGEING
JI J. Popul. Ageing
PD MAR
PY 2022
VL 15
IS 1
SI SI
BP 141
EP 171
DI 10.1007/s12062-020-09284-5
EA JUN 2020
PG 31
WC Gerontology
WE Emerging Sources Citation Index (ESCI)
SC Geriatrics & Gerontology
GA 0Q5XC
UT WOS:000537631100001
DA 2025-06-11
ER

PT J
AU White, N
   Naldoza-Drake, P
   Black, K
   Scullion, L
   Machado, L
AF White, Naomi
   Naldoza-Drake, Phoebe
   Black, Katherine
   Scullion, Luke
   Machado, Liana
TI Can Improving the Nutritional Content of Bread Enhance Cognition?
   Cognitive Outcomes from a Randomized Controlled Trial
SO JOURNAL OF COGNITIVE ENHANCEMENT
LA English
DT Article
DE Cognitive performance; Dietary intervention; Salt; Beetroot; Nuts
ID DIETARY NITRATE SUPPLEMENTATION; TESTING PERFORMANCE SHIFTS; TEST-RETEST
   RELIABILITY; 24-H URINARY SODIUM; HIGH-SALT DIET; BLOOD-PRESSURE;
   BEETROOT JUICE; OXIDATIVE STRESS; ALPHA-TOCOPHEROL; HYPERTENSION
AB Past research indicates that dietary alterations involving increases in nuts or beetroot, or decreases in salt, may have the potential to enhance cognitive functioning. The current study reports cognitive outcomes from a 12-week randomized controlled parallel intervention trial designed to evaluate the effectiveness of manipulating these ingredients in a dietary staple, bread. Participants were recruited from Dunedin, New Zealand, between February 2015 and March 2017. Initial inclusion criteria required at least one indicator of metabolic syndrome and daily consumption of at least six slices of bread, but these criteria were relaxed 6 months into the study due to recruitment difficulties. In total, 196 participants were randomized (using minimization by age group, sex, and body mass index) to consume one of four breads (hazelnut, beetroot, low salt, or a control white bread). Participants completed a computerized cognitive test battery and physiological testing at four points during the intervention. Analyses focused on 102 participants (aged 18-73 years) who finished the intervention and completed pre- and post-intervention cognitive testing. Participants who consumed the experimental breads showed no evidence of cognitive improvement relative to the control group. Furthermore, the expected physiological changes did not occur, and participants reported poor compliance. Our findings suggest that participants may have changed their eating habits during the intervention period such that they consumed less bread and ingested other counteracting nutrients, rendering the intervention ineffective. Insight from this study can be used to guide the design of future dietary interventions.
C1 [White, Naomi; Naldoza-Drake, Phoebe; Machado, Liana] Univ Otago, Dept Psychol, William James Bldg,275 Leith Walk, Dunedin 9054, New Zealand.
   [White, Naomi; Naldoza-Drake, Phoebe; Machado, Liana] Univ Otago, Brain Hlth Res Ctr, William James Bldg,275 Leith Walk, Dunedin 9054, New Zealand.
   [White, Naomi; Machado, Liana] Brain Res New Zealand, Dunedin, New Zealand.
   [Black, Katherine; Scullion, Luke] Univ Otago, Dept Human Nutr, Dunedin, New Zealand.
C3 University of Otago; University of Otago; University of Otago
RP Machado, L (corresponding author), Univ Otago, Dept Psychol, William James Bldg,275 Leith Walk, Dunedin 9054, New Zealand.; Machado, L (corresponding author), Univ Otago, Brain Hlth Res Ctr, William James Bldg,275 Leith Walk, Dunedin 9054, New Zealand.; Machado, L (corresponding author), Brain Res New Zealand, Dunedin, New Zealand.
EM liana@psy.otago.ac.nz
RI Machado, Liana/M-7311-2019; Machado, Liana/B-8140-2009
OI Machado, Liana/0000-0002-0856-3831
FU Health Research Council of New Zealand Emerging Researcher First Grant
   [14/581]; Neurological Foundation of New Zealand Small Project Grant
   [1537-SPG]
FX This research was supported by a Health Research Council of New Zealand
   Emerging Researcher First Grant awarded to Katherine Black (#14/581),
   and a Neurological Foundation of New Zealand Small Project Grant
   (#1537-SPG) awarded to Liana Machado.
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NR 50
TC 9
Z9 9
U1 1
U2 4
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 2509-3290
EI 2509-3304
J9 J COGN ENHANCE
JI J. Cogn. Enhance.
PD JUN
PY 2020
VL 4
IS 2
BP 167
EP 178
DI 10.1007/s41465-019-00149-0
PG 12
WC Neurosciences
WE Emerging Sources Citation Index (ESCI)
SC Neurosciences & Neurology
GA TC7JZ
UT WOS:000668817400005
DA 2025-06-11
ER

PT J
AU Franconi, F
   Campesi, I
   Romani, A
AF Franconi, Flavia
   Campesi, Ilaria
   Romani, Annalisa
TI Is Extra Virgin Olive Oil an Ally for Women's and Men's Cardiovascular
   Health?
SO CARDIOVASCULAR THERAPEUTICS
LA English
DT Review
ID VASCULAR ENDOTHELIAL-CELLS; SERUM URIC-ACID; ATHEROSCLEROTIC LESION
   DEVELOPMENT; MEDITERRANEAN DIET IMPROVES; INDUCED METABOLIC SYNDROME;
   ACTIVATED HUMAN MONOCYTES; REDUCES OXIDATIVE STRESS; BLOOD
   MONONUCLEAR-CELLS; LOW-DENSITY-LIPOPROTEIN; SEX-RELATED DIFFERENCES
AB Noncommunicable diseases are long-lasting and slowly progressive and are the leading causes of death and disability. They include cardiovascular diseases (CVD) and diabetes mellitus (DM) that are rising worldwide, with CVD being the leading cause of death in developed countries. Thus, there is a need to find new preventive and therapeutic approaches. Polyphenols seem to have cardioprotective properties; among them, polyphenols and/or minor polar compounds of extra virgin olive oil (EVOO) are attracting special interest. In consideration of numerous sex differences present in CVD and DM, in this narrative review, we applied "gender glasses." Globally, it emerges that olive oil and its derivatives exert some anti-inflammatory and antioxidant effects, modulate glucose metabolism, and ameliorate endothelial dysfunction. However, as in prescription drugs, also in this case there is an important gender bias because the majority of the preclinical studies are performed on male animals, and the sex of donors of cells is not often known; thus a sex/gender bias characterizes preclinical research. There are numerous clinical studies that seem to suggest the benefits of EVOO and its derivatives in CVD; however, these studies have numerous limitations, presenting also a considerable heterogeneity across the interventions. Among limitations, one of the most relevant in the era of personalized medicine, is the non-attention versus women that are few and, also when they are enrolled, sex analysis is lacking. Therefore, in our opinion, it is time to perform more long, extensive and lessheterogeneous trials enrolling both women and men.
C1 [Franconi, Flavia; Campesi, Ilaria] Ist Nazl Biostrutture Biosistemi, Lab Nazl Farmacol & Med Genere, I-07100 Sassari, Italy.
   [Campesi, Ilaria] Univ Sassari, Dipartimento Sci Biomed, I-07100 Sassari, Italy.
   [Romani, Annalisa] Univ Firenze, DiSIA, Lab PHYTOLAB Pharmaceut Cosmet Food Supplement Te, I-50019 Florence, Italy.
   [Romani, Annalisa] Univ Firenze, Lab Qual Merci & Affidabilita Prod, I-59100 Florence, Italy.
C3 University of Sassari; University of Florence; University of Florence
RP Campesi, I (corresponding author), Ist Nazl Biostrutture Biosistemi, Lab Nazl Farmacol & Med Genere, I-07100 Sassari, Italy.; Campesi, I (corresponding author), Univ Sassari, Dipartimento Sci Biomed, I-07100 Sassari, Italy.
EM flavia.franconi@gmail.com; icampesi@uniss.it; annalisa.romani@unifi.it
RI Campesi, Ilaria/AFE-4953-2022
OI CAMPESI, ILARIA/0000-0002-1681-6448
FU EXTRANUTRAOILS, MIPAF Project, 2019; BIOSINOILS Project, PEI-AGRI,
   GO2017, Tuscany Region, Italy
FX This work was supported by EXTRANUTRAOILS, MIPAF Project, 2019, and
   BIOSINOILS Project, PEI-AGRI, GO2017, Tuscany Region, Italy.
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NR 398
TC 18
Z9 19
U1 0
U2 13
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1755-5914
EI 1755-5922
J9 CARDIOVASC THER
JI Cardiovasc. Ther.
PD APR 27
PY 2020
VL 2020
AR 6719301
DI 10.1155/2020/6719301
PG 33
WC Cardiac & Cardiovascular Systems; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Pharmacology & Pharmacy
GA LN9RV
UT WOS:000533269200003
PM 32454893
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Santos-Bezerra, DP
   Machado-Lima, A
   Monteiro, MB
   Admoni, SN
   Perez, RV
   Machado, CG
   Shimizu, MH
   Cavaleiro, AM
   Thieme, K
   Queiroz, MS
   Machado, UF
   Giannella-Neto, D
   Passarelli, M
   Corrêa-Giannella, ML
AF Santos-Bezerra, Daniele P.
   Machado-Lima, Adriana
   Monteiro, Maria Beatriz
   Admoni, Sharon N.
   Perez, Ricardo V.
   Machado, Cleide G.
   Shimizu, Maria Heloiza
   Cavaleiro, Ana M.
   Thieme, Karina
   Queiroz, Marcia S.
   Machado, Ubiratan F.
   Giannella-Neto, Daniel
   Passarelli, Marisa
   Correa-Giannella, Maria Lucia
TI Dietary advanced glycated end-products and medicines influence the
   expression of SIRT1 and DDOST in peripheral mononuclear
   cells from long-term type 1 diabetes patients
SO DIABETES & VASCULAR DISEASE RESEARCH
LA English
DT Article
DE Type 1 diabetes; microvascular complications; advanced glycation
   end-products; receptor for advanced glycation end-products; advanced
   glycation end-product receptor 1; Sirtuin 1
ID VASCULAR COMPLICATIONS; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   OXIDATIVE STRESS; AGE RESTRICTION; RAGE EXPRESSION; SERUM-LEVELS;
   RECEPTOR; DISEASE; SYSTEM
AB Quantitative polymerase chain reaction was employed to quantify expression of two genes coding for advanced glycation end-product receptors [RAGE (AGER) and AGER1 (DDOST)] and of the gene coding the deacetylase SIRT1 (SIRT1) in peripheral blood mononuclear cells from type 1 diabetes patients without [Group A, n = 35; 28.5 (24-39) years old; median (interquartile interval)] or with at least one microvascular complication [Group B, n = 117; 34.5 (30-42) years old]; 31 healthy controls were also included. In a subgroup of 48 patients, daily advanced glycation end-products intake before blood collection was assessed. Lower expression of DDOST was found in patients than in controls after adjustment for sex, age, use of statins, angiotensin-converting enzyme inhibitors and angiotensin receptor blockers. Higher expressions of AGER, DDOST and SIRT1 were observed in Group A. Stratifying by complications, AGER and DDOST expressions were higher in those without retinopathy and without diabetic kidney disease, respectively, compared to patients with these complications. Patients using statins or angiotensin receptor blockers presented higher expression of DDOST. Expression of SIRT1 was higher in patients consuming >= 12,872 KU daily of advanced glycation end-products. Although AGER, DDOST and SIRT1 are differently expressed in peripheral blood mononuclear cells from type 1 diabetes patients with and without microvascular complications, they are also influenced by dietary advanced glycation end-products and by statins and angiotensin receptor blockers.
C1 [Santos-Bezerra, Daniele P.; Monteiro, Maria Beatriz; Admoni, Sharon N.; Perez, Ricardo V.; Cavaleiro, Ana M.; Thieme, Karina; Correa-Giannella, Maria Lucia] Univ Sao Paulo FMUSP, Lab Carboidratos & Radioimunoensaios LIM 18, Fac Med, Sao Paulo, Brazil.
   [Machado-Lima, Adriana; Passarelli, Marisa] Univ Sao Paulo FMUSP, Lab Lipides LIM 10, Fac Med, Sao Paulo, Brazil.
   [Machado, Cleide G.] Univ Sao Paulo HCFMUSP, Hosp Clin, Div Oftalmol, Fac Med, Sao Paulo, Brazil.
   [Shimizu, Maria Heloiza] Univ Sao Paulo FMUSP, Lab Pesquisa Basica Doencas Renais LIM 12, Fac Med, Sao Paulo, Brazil.
   [Queiroz, Marcia S.] Univ Sao Paulo HCFMUSP, Hosp Clin, Div Endocrinol, Fac Med, Sao Paulo, Brazil.
   [Machado, Ubiratan F.] Univ Sao Paulo, Inst Ciencias Biomed, Lab Metab & Endocrinol, Sao Paulo, Brazil.
   [Giannella-Neto, Daniel; Correa-Giannella, Maria Lucia] Univ Nove de Julho, Programa Posgrad Med, Sao Paulo, Brazil.
   [Correa-Giannella, Maria Lucia] Univ Sao Paulo, Nucleo Estudos & Terapia Celular & Mol NUCEL NETC, Fac Med, Sao Paulo, Brazil.
C3 Universidade de Sao Paulo; Universidade de Sao Paulo; Universidade de
   Sao Paulo; Universidade de Sao Paulo; Universidade de Sao Paulo;
   Universidade de Sao Paulo; Universidade Nove de Julho; Universidade de
   Sao Paulo
RP Corrêa-Giannella, ML (corresponding author), Ave Dr Arnaldo 455, BR-01246903 Sao Paulo, Brazil.
EM malugia@lim25.fm.usp.br
RI Monteiro, Maria/M-1727-2013; Queiroz, Marcia/HDM-8486-2022; Machado,
   Cleide Guimarães/GSM-6701-2022; Correa-Giannella, Maria
   Lúcia/N-3834-2019; Machado, Ubiratan/F-3096-2017; Passarelli,
   Marisa/C-8129-2012; Shimizu, Maria/B-7887-2013; Machado-Lima,
   Adriana/H-4319-2012; Queiroz, Marcia/L-9097-2015; Thieme,
   Karina/C-8560-2013; Santos-Bezerra, Daniele/K-7579-2015
OI Machado-Lima, Adriana/0000-0002-5741-3418; Queiroz,
   Marcia/0000-0001-5113-6299; Correa-Giannella, Maria
   Lucia/0000-0003-3655-4446; Vessoni Perez, Ricardo/0000-0001-8880-2400;
   Thieme, Karina/0000-0003-2896-4445; Santos-Bezerra,
   Daniele/0000-0003-3464-8166
FU Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
   [12/25490-8, 12/04831-1, 16/15603-0]; Conselho Nacional de
   Desenvolvimento Cientifico e Tecnologico (CNPq) fellowships; Fundacao de
   Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [16/15603-0,
   12/25490-8] Funding Source: FAPESP
FX This work was supported by grants from Fundacao de Amparo a Pesquisa do
   Estado de Sao Paulo (FAPESP) to D.P.S.-B. (12/25490-8) and to M.P.,
   U.F.M. and M.L.C.-G. (12/04831-1 and 16/15603-0). U.F.M. and M.L.C.-G.
   are recipients of Conselho Nacional de Desenvolvimento Cientifico e
   Tecnologico (CNPq) fellowships.
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NR 34
TC 13
Z9 14
U1 0
U2 18
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1479-1641
EI 1752-8984
J9 DIABETES VASC DIS RE
JI Diabetes Vasc. Dis. Res.
PD JAN
PY 2018
VL 15
IS 1
BP 81
EP 89
DI 10.1177/1479164117733918
PG 9
WC Endocrinology & Metabolism; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Cardiovascular System & Cardiology
GA FQ5EB
UT WOS:000418380200010
PM 29027826
DA 2025-06-11
ER

PT J
AU Singh, JA
   Cleveland, JD
AF Singh, Jasvinder A.
   Cleveland, John D.
TI Gout and the Risk of Incident Obstructive Sleep Apnea in Adults 65 Years
   or Older: An Observational Study
SO JOURNAL OF CLINICAL SLEEP MEDICINE
LA English
DT Article
DE gout; obstructive sleep apnea; older adults; OSA; risk
ID C-REACTIVE PROTEIN; URIC-ACID; CARDIOVASCULAR-DISEASE; ENDOTHELIAL
   FUNCTION; ADMINISTRATIVE DATA; METABOLIC SYNDROME; OXIDATIVE STRESS;
   INFLAMMATION; HEALTH; CARE
AB Study Objectives: To assess whether gout is associated with a higher risk of obstructive sleep apnea (OSA) in older adults.
   Methods: We used the 5% United States Medicare beneficiary sample from 2006-2012 to assess whether gout was independently associated with new diagnosis of OSA in adults 65 years or older, adjusting for demographics, medical comorbidity (Charlson-Romano index) and hypertension, hyperlipidemia and coronary artery disease, and the use of medications for cardiovascular diseases or gout (allopurinol, febuxostat).
   Results: Based on 10,448,472 person-years of follow-up in a cohort of 1.74 million adults 65 years or older, the crude incidence rates of OSA were 14.3 per 1,000 person-years in people with gout and 3.9 per 1,000 person-years in people without gout. In multivariable-adjusted analyses, gout was associated with higher risk of a new diagnosis of OSA during the follow-up, hazard ratio was 2.07 (95% confidence interval [CI] 2.00, 2.15). In sensitivity analyses that substituted continuous Charlson-Romano score with a categorical variable or individual Charlson-Romano comorbidities plus hypertension, hyperlipidemia and coronary artery disease, the main finding was confirmed, hazard ratios were 2.11 (95% CI 2.03, 2.18) and 1.79 (95% CI 1.73, 1.85).
   Conclusions: The independent association of gout with a twofold higher risk of OSA in older adults indicates that common mechanisms may be shared by the two conditions. More studies are needed to investigate these mechanisms further.
C1 [Singh, Jasvinder A.] VA Med Ctr, Med Serv, Birmingham, AL USA.
   [Singh, Jasvinder A.; Cleveland, John D.] Univ Alabama Birmingham, Sch Med, Dept Med, Birmingham, AL 35294 USA.
   [Singh, Jasvinder A.] Univ Alabama Birmingham, Sch Publ Hlth, Div Epidemiol, Birmingham, AL 35294 USA.
C3 University of Alabama System; University of Alabama Birmingham;
   University of Alabama System; University of Alabama Birmingham
RP Singh, JA (corresponding author), Univ Alabama Birmingham, Fac Off Tower 805B,510 20th St S, Birmingham, AL 35294 USA.
EM Jasvinder.md@gmail.com
RI Singh, Jasvinder/R-6172-2019
FU Division of Rheumatology at the University of Alabama at Birmingham;
   Horizon pharmaceuticals
FX All authors have seen and approved the manuscript. This material is the
   result of work supported by research funds from the Division of
   Rheumatology at the University of Alabama at Birmingham and the
   resources and use of facilities at the Birmingham VA Medical Center,
   Birmingham, Alabama, United States. The funding body did not play any
   role in design, collection, analysis, and interpretation of data. JAS
   has received research grants from Takeda and Savient pharmaceuticals and
   consultant fees from Savient, Takeda, Regeneron, Merz, Iroko,
   Bioiberica, Crealta/Horizon and Allergan pharmaceuticals, WebMD, UBM
   LLC, Medscape, Fidia pharmaceuticals and the American College of
   Rheumatology. JAS serves as the principal investigator for an
   investigator-initiated study funded by Horizon pharmaceuticals through a
   grant to DINORA, Inc., a 501 (c)(3) entity. JAS is a member of the
   executive of OMERACT, an organization that develops outcome measures in
   rheumatology and receives arms-length funding from 36 companies; a
   member of the American College of Rheumatology's (ACR) Annual Meeting
   Planning Committee (AMPC); Chair of the ACR Meet-the-Professor, Workshop
   and Study Group Subcommittee; and a member of the Veterans Affairs
   Rheumatology Field Advisory Committee. JAS is the editor and the
   Director of the UAB Cochrane Musculoskeletal Group Satellite Center on
   Network Meta-analysis. JDC reports no conflicts of interest.
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NR 44
TC 13
Z9 14
U1 0
U2 6
PU AMER ACAD SLEEP MEDICINE
PI DARIEN
PA 2510 N FRONTAGE RD, DARIEN, IL 60561 USA
SN 1550-9389
EI 1550-9397
J9 J CLIN SLEEP MED
JI J. Clin. Sleep Med.
PY 2018
VL 14
IS 9
BP 1521
EP 1527
DI 10.5664/jcsm.7328
PG 7
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA HP1GP
UT WOS:000461414400010
PM 30176977
OA Green Published
DA 2025-06-11
ER

PT J
AU van Koppen, A
   Verschuren, L
   van den Hoek, AM
   Verheij, J
   Morrison, MC
   Li, K
   Nagabukuro, H
   Costessi, A
   Caspers, MPM
   van den Broek, TJ
   Sagartz, J
   Kluft, C
   Beysen, C
   Emson, C
   van Gool, AJ
   Goldschmeding, R
   Stoop, R
   Bobeldijk-Pastorova, I
   Turner, SM
   Hanauer, G
   Hanemaaijer, R
AF van Koppen, Arianne
   Verschuren, Lars
   van den Hoek, Anita M.
   Verheij, Joanne
   Morrison, Martine C.
   Li, Kelvin
   Nagabukuro, Hiroshi
   Costessi, Adalberto
   Caspers, Martien P. M.
   van den Broek, Tim J.
   Sagartz, John
   Kluft, Cornelis
   Beysen, Carine
   Emson, Claire
   van Gool, Alain J.
   Goldschmeding, Roel
   Stoop, Reinout
   Bobeldijk-Pastorova, Ivana
   Turner, Scott M.
   Hanauer, Guido
   Hanemaaijer, Roeland
TI Uncovering a Predictive Molecular Signature for the Onset of
   NASH-Related Fibrosis in a Translational NASH Mouse Model
SO CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
LA English
DT Article
DE Systems Biology; Metabolic Syndrome; Liver Disease; Diagnosis
ID FATTY LIVER-DISEASE; NONALCOHOLIC STEATOHEPATITIS;
   HEPATOCELLULAR-CARCINOMA; INSULIN-RESISTANCE; PLASMA; TRANSPLANTATION;
   CHROMATOGRAPHY; PATHOGENESIS; INFLAMMATION; OUTCOMES
AB BACKGROUND & AIMS: The incidence of nonalcoholic steatohepatitis (NASH) is increasing. The pathophysiological mechanisms of NASH and the sequence of events leading to hepatic fibrosis are incompletely understood. The aim of this study was to gain insight into the dynamics of key molecular processes involved in NASH and to rank early markers for hepatic fibrosis.
   METHODS: A time-course study in low-density lipoprotein-receptor knockout. Leiden mice on a high-fat diet was performed to identify the temporal dynamics of key processes contributing to NASH and fibrosis. An integrative systems biology approach was used to elucidate candidate markers linked to the active fibrosis process by combining transcriptomics, dynamic proteomics, and histopathology. The translational value of these findings were confirmed using human NASH data sets.
   RESULTS: High-fat-diet feeding resulted in obesity, hyperlipidemia, insulin resistance, and NASH with fibrosis in a time-dependent manner. Temporal dynamics of key molecular processes involved in the development of NASH were identified, including lipid metabolism, inflammation, oxidative stress, and fibrosis. A data-integrative approach enabled identification of the active fibrotic process preceding histopathologic detection using a novel molecular fibrosis signature. Human studies were used to identify overlap of genes and processes and to perform a network biology-based prioritization to rank top candidate markers representing the early manifestation of fibrosis.
   CONCLUSIONS: An early predictive molecular signature was identified that marked the active profibrotic process before histopathologic fibrosis becomes manifest. Early detection of the onset of NASH and fibrosis enables identification of novel blood-based biomarkers to stratify patients at risk, development of new therapeutics, and help shorten (pre) clinical experimental time frames.
C1 [van Koppen, Arianne; van den Hoek, Anita M.; Morrison, Martine C.; Stoop, Reinout; Bobeldijk-Pastorova, Ivana; Hanemaaijer, Roeland] TNO, Dept Metab Hlth Res, Zernikedreef 9, NL-2333 CK Leiden, Netherlands.
   [van Koppen, Arianne; Goldschmeding, Roel] Univ Med Ctr Utrecht, Utrecht, Netherlands.
   [Verschuren, Lars; Caspers, Martien P. M.; van den Broek, Tim J.; van Gool, Alain J.] TNO, Dept Microbiol & Syst Biol, Zeist, Netherlands.
   [Verheij, Joanne] Univ Amsterdam, Med Ctr, Dept Pathol, Amsterdam, Netherlands.
   [Li, Kelvin; Beysen, Carine; Emson, Claire; Turner, Scott M.] Kinemed Inc, Emeryville, CA USA.
   [Nagabukuro, Hiroshi; Hanauer, Guido] Takeda Pharmaceut Co, Fujisawa, Kanagawa, Japan.
   [Costessi, Adalberto] BaseClear BV, Leiden, Netherlands.
   [Sagartz, John] Seventh Wave, Maryland Hts, MO USA.
   [Kluft, Cornelis] Good Biomarker Sci BV, Leiden, Netherlands.
   [van Gool, Alain J.] Radboud Univ Nijmegen, Med Ctr, Nijmegen, Netherlands.
C3 Netherlands Organization Applied Science Research; Utrecht University;
   Utrecht University Medical Center; Netherlands Organization Applied
   Science Research; University of Amsterdam; Kinemed Inc; Takeda
   Pharmaceutical Company Ltd; Radboud University Nijmegen
RP van Koppen, A (corresponding author), TNO, Dept Metab Hlth Res, Zernikedreef 9, NL-2333 CK Leiden, Netherlands.
EM arianne.vankoppen@tno.nl
RI van Gool, Alain/L-4328-2015; Morrison, Martine/C-3168-2014
OI van Gool, Alain/0000-0003-0010-5286; Morrison,
   Martine/0000-0003-4996-943X; Verheij, Joanne/0000-0003-1283-630X
FU ZonMW [114025001]; TNO research program "Predictive Health Technologies"
FX This work was generated by a consortium that was supported by grant
   114025001 from ZonMW, and the TNO research program "Predictive Health
   Technologies."
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NR 42
TC 47
Z9 51
U1 0
U2 8
PU ELSEVIER INC
PI SAN DIEGO
PA 525 B STREET, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 2352-345X
J9 CELL MOL GASTROENTER
JI Cell. Mol. Gastroenterol. Hepatol.
PY 2018
VL 5
IS 1
BP 83
EP +
DI 10.1016/j.jcmgh.2017.10.001
PG 26
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA FV4NX
UT WOS:000424551700009
PM 29276754
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Gozal, D
   Ham, SA
   Mokhlesi, B
AF Gozal, David
   Ham, Sandra A.
   Mokhlesi, Babak
TI Sleep Apnea and Cancer: Analysis of a Nationwide Population Sample
SO SLEEP
LA English
DT Article
DE cancer; sleep apnea; prevalence; melanoma; pancreatic cancer
ID TUMOR-ASSOCIATED MACROPHAGES; RENAL-CELL CARCINOMA; METABOLIC SYNDROME;
   COLORECTAL-CANCER; OXIDATIVE STRESS; MOUSE MODEL; COHORT; PREVALENCE;
   OBESITY; HYPOXIA
AB Study Objectives: Epidemiological evidence from relatively small cohorts suggests that obstructive sleep apnea (OSA) is associated with higher cancer incidence and mortality. Here we aimed to determine whether cancer incidence for major cancer types and risk of metastases or mortality from cancer are increased in the presence of OSA.
   Methods: All OSA diagnoses included in an employee-sponsored health insurance database spanning the years 2003-2012 were identified and 1:1 matched demographically based on age, gender, and state of residence, or alternatively matched by comorbidities. The incidence of 12 types of cancer was assessed. In addition, another cohort of patients with a primary diagnosis of cancer was retrieved, and the risk of metastatic disease or cancer mortality was determined as a function of the presence or absence of OSA. Multivariate Cox proportional hazards regression models were fitted to assess the independent associations between OSA and outcomes of interest.
   Results: Based on a cohort of similar to 5.6 million individuals, the incidence of all cancer diagnoses combined was similar in OSA and retrospectively matched cases. However, the adjusted risk of pancreatic and kidney cancer and melanoma were significantly higher in patients with OSA, while the risk of colorectal, breast, and prostate cancers appeared to be lower. Among individuals with a diagnosis of cancer, the presence of OSA was not associated with an increased risk for metastasis or death.
   Conclusions: In a large nationally representative health insurance database, OSA appears to increase the risk for only a very selective number of cancer types, and does not appear to be associated with an increased risk of metastatic cancer or cancer-related deaths.
C1 [Gozal, David] Univ Chicago, Div Biol Sci, Prizkter Sch Med, Sect Pediat Sleep Med & Pulmonol,Dept Pediat, Chicago, IL 60637 USA.
   [Ham, Sandra A.] Univ Chicago, Ctr Hlth & Social Sci, Chicago, IL 60637 USA.
   [Mokhlesi, Babak] Univ Chicago, Sleep Disorders Ctr, Chicago, IL 60637 USA.
   [Mokhlesi, Babak] Univ Chicago, Dept Med, Sect Pulm & Crit Care Med, Chicago, IL 60637 USA.
C3 University of Chicago; University of Chicago; University of Chicago;
   University of Chicago
RP Gozal, D (corresponding author), Univ Chicago, Knapp Ctr Biomed Discovery, Pritzker Sch Med, Sect Pediat Sleep Med,Dept Pediat, Room 4100,900 E 57th St,Mailbox 4, Chicago, IL 60637 USA.
EM dgozal@uchicago.edu
RI Gozal, David/ABH-3805-2020
OI Ham, Sandra/0000-0002-1966-2413
FU Herbert T. Abelson Chair in Pediatrics
FX This was not an industry supported study. This study was supported in
   part by the Herbert T. Abelson Chair in Pediatrics to Dr. Gozal. The
   other authors have indicated no financial conflicts of interest.
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NR 47
TC 154
Z9 166
U1 0
U2 18
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
EI 1550-9109
J9 SLEEP
JI Sleep
PD AUG 1
PY 2016
VL 39
IS 8
BP 1493
EP 1500
DI 10.5665/sleep.6004
PG 8
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA DT8NF
UT WOS:000381746800003
PM 27166241
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Ren, G
   Eskandari, P
   Wang, SQ
   Smas, CM
AF Ren, Gang
   Eskandari, Parisa
   Wang, Siqian
   Smas, Cynthia M.
TI Expression, regulation and functional assessment of the 80 amino acid
   Small Adipocyte Factor 1 (Smaf1) protein in adipocytes
SO ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
LA English
DT Article
DE Adipocyte; Adipogenesis; PPAR gamma; Differentiation; Lipid metabolism;
   Smaf1; Adipogenin
ID NECROSIS-FACTOR-ALPHA; PPAR-GAMMA AGONISTS; INSULIN-RESISTANCE;
   METABOLIC SYNDROME; ADIPOSE-TISSUE; ENDOPLASMIC-RETICULUM; 3T3-L1
   ADIPOCYTES; GENE-EXPRESSION; LIPID DROPLETS; ER STRESS
AB The gene for Small Adipocyte Factor 1, Smaf1 (also known as adipogenin, ADIG), encodes a similar to 600 base transcript that is highly upregulated during 3T3-L1 in vitro adipogenesis and markedly enriched in adipose tissues. Based on the lack of an obvious open reading frame in the Smaf1 transcript, it is not known if the Smaf1 gene is protein coding or non-coding RNA. Using a peptide from a putative open reading frame of Smaf1 as antigen, we generated antibodies for western analysis. Our studies prove that Smaf1 encodes an adipose-enriched protein which in western blot analysis migrates at similar to 10 kDa. Rapid induction of Smaf1 protein occurs during in vitro adipogenesis and its expression in 3T3-L1 adipocytes is positively regulated by insulin and glucose. Moreover, siRNA studies reveal that expression of Smaf1 in adipocytes is wholly dependent on PPAR gamma. On the other hand, use of siRNA for Smaf1 to nearly abolish its protein expression in adipocytes revealed that Smaf1 does not have a major role in adipocyte triglyceride accumulation, lipolysis or insulin-stimulated pAkt induction. However, immunolocalization studies using HA-tagged Smaf1 reveal enrichment at adipocyte lipid droplets. Together our findings show that Smaf1 is a novel small protein endogenous to adipocytes and that Smaf1 expression is closely tied to PPAR gamma-mediated signals and the adipocyte phenotype. (C) 2015 Elsevier Inc. All rights reserved.
C1 [Ren, Gang; Eskandari, Parisa; Wang, Siqian; Smas, Cynthia M.] Univ Toledo, Coll Med, Dept Biochem & Canc Biol, Toledo, OH 43614 USA.
   [Ren, Gang; Eskandari, Parisa; Wang, Siqian; Smas, Cynthia M.] Univ Toledo, Coll Med, Ctr Diabet & Endocrine Res, Toledo, OH 43614 USA.
   [Wang, Siqian] Shangqiu Med Coll, Dept Nursing, Shangqiu City, Peoples R China.
C3 University System of Ohio; University of Toledo; University System of
   Ohio; University of Toledo
RP Smas, CM (corresponding author), Univ Toledo, Coll Med, Dept Biochem & Canc Biol, Toledo, OH 43614 USA.; Smas, CM (corresponding author), Univ Toledo, Coll Med, Ctr Diabet & Endocrine Res, Toledo, OH 43614 USA.
EM cynthia.smas@utoledo.edu
FU NIH/NIDDK [R21DK066055]
FX The study was funded in part by NIH/NIDDK grant R21DK066055 (Smas,
   P.I.). The brown preadipocyte cell line was provided by Dr. C.R. Kahn.
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NR 37
TC 7
Z9 9
U1 0
U2 4
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0003-9861
EI 1096-0384
J9 ARCH BIOCHEM BIOPHYS
JI Arch. Biochem. Biophys.
PD JAN 15
PY 2016
VL 590
BP 27
EP 36
DI 10.1016/j.abb.2015.09.019
PG 10
WC Biochemistry & Molecular Biology; Biophysics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics
GA DC3NI
UT WOS:000369125600004
PM 26427354
DA 2025-06-11
ER

PT J
AU Huang, SC
   Fang, WH
   Wang, CC
   Chen, WL
   Kao, TW
   Hwang, LL
   Chu, CM
   Chang, YW
AF Huang, Shang-Cheng
   Fang, Wen-Hui
   Wang, Chung-Ching
   Chen, Wei-Liang
   Kao, Tung-Wei
   Hwang, Ling-Ling
   Chu, Chi-Ming
   Chang, Yaw-Wen
TI Alteration of Heart Rate Variability in People With Bowel Preparation
   Before Colonoscopy
SO MEDICINE
LA English
DT Article
ID CHRONIC KIDNEY-DISEASE; ATHEROSCLEROSIS RISK; SHORT-TERM; METABOLIC
   SYNDROME; MORTALITY; ASSOCIATION; STRESS; HYPERTENSION; POTASSIUM;
   FAILURE
AB In current health examination setting, people frequently undergo heart rate variability (HRV) analysis and colonoscopy on the same day. However, it remains unclear whether the bowel preparation before colonoscopy affects HRV. This study aimed to evaluate the association between HRV and bowel preparation.We conducted a cross-sectional observational study of 1755 people from January 2012 to December 2013 in Taipei, Taiwan. The participants, aged 45 to 65 years, received health examinations that included a physical examination, blood tests, and an HRV analysis. Among these people, 1099 additionally received a colonoscopy on the same day and underwent bowel preparation 1 day before the colonoscopy. The association between HRV and bowel preparation was derived by a multivariable linear regression with adjusted confounding factors.Bowel preparation was associated with a lower standard deviation of the normal-to-normal intervals (SDNN), the root mean square of the successive differences (RMSSD), low-frequency power (LF), and high-frequency power (HF) (all P<0.0001). After adjusting confounding factors, bowel preparation remained correlated with lower SDNN, RMSSD, LF, and HF (all P<0.0001). Higher serum phosphorus and lower serum potassium levels were noted in the bowel preparation group (P<0.0001), and an association between lower HRV and higher serum phosphorus and lower serum potassium levels was only noted in the bowel preparation group.Bowel preparation was significantly associated with lower HRV. The underlying mechanism may be related to an electrolyte imbalance. Cautions may be needed when interpreting HRV reports for people receiving bowel preparations before colonoscopy.
C1 [Huang, Shang-Cheng; Fang, Wen-Hui; Wang, Chung-Ching; Chen, Wei-Liang; Kao, Tung-Wei; Chang, Yaw-Wen] Triserv Gen Hosp, Natl Def Med Ctr, Dept Family Med & Community Hlth, 325,Sec 2,Chenggong Rd, Taipei 114, Taiwan.
   [Huang, Shang-Cheng] Taipei Med Univ, Coll Med, Dept Grad Inst Med Sci, Taipei, Taiwan.
   [Hwang, Ling-Ling] Taipei Med Univ, Coll Med, Dept Physiol, Taipei, Taiwan.
   [Chu, Chi-Ming] Natl Def Med Ctr, Sch Publ Hlth, Taipei 114, Taiwan.
C3 National Defense Medical Center; Tri-Service General Hospital; Taipei
   Medical University; Taipei Medical University; National Defense Medical
   Center
RP Chang, YW (corresponding author), Triserv Gen Hosp, Natl Def Med Ctr, Dept Family Med & Community Hlth, 325,Sec 2,Chenggong Rd, Taipei 114, Taiwan.
EM yawwenc@mail.ndmctsgh.edu.tw
RI Hwang, Ling-Ling/I-9711-2018; Chang, Yaw-Wen/AAF-2630-2020; Chu,
   Christopher/HHN-4195-2022
OI Chu, Cordia/0000-0002-3683-5638; Chang, Yaw-Wen/0000-0002-8436-0518
FU Tri-Service General Hospital, Taipei, Taiwan [TSGH-C102-014]
FX This study was financially supported by Tri-Service General Hospital,
   Taipei, Taiwan (TSGH-C102-014).
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NR 38
TC 1
Z9 2
U1 1
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD NOV
PY 2015
VL 94
IS 44
AR e1926
DI 10.1097/MD.0000000000001926
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA DC9IX
UT WOS:000369536100035
PM 26554795
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Choi, SH
   Kang, HY
   Choi, SY
   Kim, MN
   Yang, JI
   Chung, SJ
   Yang, SY
   Kim, YS
   Kim, JS
AF Choi, Seung Ho
   Kang, Hae Yeon
   Choi, Su Yeon
   Kim, Mi Na
   Yang, Jong In
   Chung, Su Jin
   Yang, Sun Young
   Kim, Young Sun
   Kim, Joo Sung
TI Colorectal adenoma is associated with coronary artery calcification in a
   Korean population
SO ATHEROSCLEROSIS
LA English
DT Article
DE Colorectal adenoma; Coronary artery calcification; Screening
ID METABOLIC SYNDROME; OXIDATIVE STRESS; INSULIN-RESISTANCE;
   ADIPOSE-TISSUE; RISK-FACTORS; CANCER; CALCIUM; DISEASE; OBESITY;
   QUANTIFICATION
AB Objective: Colorectal adenoma and coronary atherosclerosis have similar risk factors. The aim of this study was to investigate the association between colorectal adenoma and coronary artery calcification (CAC), which is used as a surrogate marker for coronary atherosclerosis.
   Methods: This is a cross-sectional study of 398 Koreans (290 males, mean age of 56.8 +/- 8.1 years) who underwent CAC scoring by multi-slice computed tomography and colonoscopy on the same day as the screening examination. The CAC scores were divided into the following three categories according to severity: absent (CAC score = 0), mild (0 < CAC score <= 100), and moderate-to-severe CAC (CAC score > 100).
   Results: Colorectal adenoma was detected in 149 (37.4%) subjects and was significantly associated with a CAC score of > 0 (OR = 1.66, 95% CI = 1.05-2.64, P = 0.032), including both mild (OR = 1.80, 95% CI = 1.06-3.03, P = 0.029) and moderate-to-severe CAC (OR = 1.95, 95% CI = 1.05-3.63, P = 0.035), in multivariate analysis after adjusting for age, gender and other risk factors. The proportion of subjects with colorectal adenoma and advanced adenoma progressively increased with increasing CAC score (colorectal adenoma 28.9%-54.1%, P for trend < 0.001; advanced adenoma 7.0%-16.4%, P for trend = 0.026).
   Conclusion: Colorectal adenoma is related to coronary artery calcification independent of traditional risk factors for asymptomatic Koreans. The prevalence of advanced adenoma is more common in individuals with severe coronary atherosclerosis. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
C1 [Choi, Seung Ho; Kang, Hae Yeon; Choi, Su Yeon; Kim, Mi Na; Yang, Jong In; Chung, Su Jin; Yang, Sun Young; Kim, Young Sun; Kim, Joo Sung] Seoul Natl Univ Hosp, Healthcare Syst Gangnam Ctr, Dept Internal Med, Inst Healthcare Res, Seoul 135984, South Korea.
   [Kim, Joo Sung] Seoul Natl Univ, Coll Med, Dept Internal Med, Liver Res Inst, Seoul 151, South Korea.
C3 Seoul National University (SNU); Seoul National University Hospital;
   Seoul National University (SNU)
RP Kang, HY (corresponding author), Seoul Natl Univ Hosp, Healthcare Syst Gangnam Ctr, Dept Internal Med, Gangnam Finance Ctr,Inst Healthcare Res, 39th FL,737 Yeoksam Dong, Seoul 135984, South Korea.
EM joybell77@hanmail.net
RI Yang, Jong-In/C-4300-2013; Kim, You Sun/B-2881-2015; Choi,
   Seung/C-4314-2013; Kim, Joo Sung/ISB-4397-2023; Choi,
   Su-Yeon/C-4312-2013; Chung, Su/G-5382-2019
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NR 39
TC 7
Z9 7
U1 0
U2 1
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0021-9150
EI 1879-1484
J9 ATHEROSCLEROSIS
JI Atherosclerosis
PD OCT
PY 2015
VL 242
IS 2
BP 515
EP 520
DI 10.1016/j.atherosclerosis.2015.08.004
PG 6
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA CR7DV
UT WOS:000361509000020
PM 26298744
DA 2025-06-11
ER

PT J
AU Hwang, JJ
   Lee, DH
   Yoon, H
   Shin, CM
   Park, YS
   Kim, N
AF Hwang, Jae Jin
   Lee, Dong Ho
   Yoon, Hyuk
   Shin, Cheol Min
   Park, Young Soo
   Kim, Nayoung
TI Is Atrial Fibrillation a Risk Factor for Gastroesophageal Reflux Disease
   Occurrence?
SO MEDICINE
LA English
DT Article
ID NEUROCARDIAC FUNCTION; METABOLIC SYNDROME; OXIDATIVE STRESS; PULMONARY
   VEIN; LIFETIME RISK; PATHOGENESIS; ESOPHAGUS; INFLAMMATION; ASSOCIATION;
   ABLATION
AB Recent studies have reported an association between gastroesophageal reflux disease (GERD) and atrial fibrillation (AF). The objective of the present study was to evaluate whether AF is one of the risk factors for GERD occurrence.In this hospital-based, retrospective, case-control study, the patients were classified into 2 groups. The patients diagnosed with new AF were assigned to the AF group (n=1612); those diagnosed without AF and GERD were assigned to the control group (n=1612). The subjects in the control group were selected from outpatients of total healthcare center without a history of AF or GERD, and matched for age and gender. We evaluated the incidence of GERD and risk factors for GERD occurrence between the 2 groups.The number of patients experiencing occurrence of GERD during the follow-up period was significantly higher in the AF group than those in the control group, respectively (129 patients vs 98 subjects, P=0.037). The incidence of GERD was significantly higher in the AF group than in the control group by Kaplan-Meier analysis with log-rank test (P=0.008). The AF group's adjusted hazard ratio of GERD occurrence against that of the control group was 1.37 (95% confidence interval [CI]: 1.16-1.57; P=0.009) according to Cox's proportional hazard model.The presence of AF appears to increase the incidence of GERD and may be considered a risk factor for the development of GERD. Further, large prospective and cohort studies will be required to better establish the correlation of GERD with AF.
C1 [Hwang, Jae Jin; Lee, Dong Ho; Yoon, Hyuk; Shin, Cheol Min; Park, Young Soo; Kim, Nayoung] Seoul Natl Univ, Bundang Hosp, Coll Med, Dept Internal Med, 82,Gumi Ro 173 Beon Gil, Songnam, Gyeonggi Do, South Korea.
C3 Seoul National University (SNU)
RP Lee, DH (corresponding author), Seoul Natl Univ, Bundang Hosp, Coll Med, Dept Internal Med, 82,Gumi Ro 173 Beon Gil, Songnam, Gyeonggi Do, South Korea.
EM dhljohn@yahoo.co.kr
RI Kim, Nayoung/J-5387-2012; Lee, Dong-Ho/J-5576-2012; Yoon,
   Hyuk/AAT-4978-2020
OI Kim, Nayoung/0000-0002-9397-0406; Yoon, Hyuk/0000-0002-2657-0349
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NR 35
TC 7
Z9 8
U1 1
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD OCT
PY 2015
VL 94
IS 43
AR e1921
DI 10.1097/MD.0000000000001921
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA DC9IS
UT WOS:000369535500068
PM 26512618
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Yoon, JH
   Kim, JY
   Park, JK
   Ko, SB
AF Yoon, Jin-Ha
   Kim, Jang-Young
   Park, Jong-Ku
   Ko, Sang-Baek
TI Oxidative Damage Markers Are Significantly Associated with the Carotid
   Artery Intima-Media Thickness after Controlling for Conventional Risk
   Factors of Atherosclerosis in Men
SO PLOS ONE
LA English
DT Article
ID LIPID-PEROXIDATION; ENDOTHELIAL DYSFUNCTION; STRESS; ISOPROSTANES;
   APOPTOSIS; CALCIFICATION; DISEASE; 8-OHDG; DNA
AB Background
   This study aimed to assess the association between oxidative damage markers and carotid artery intima-media thickness (CIMT) after controlling for conventional risk factors of atherosclerosis in multiple logistic regression models.
   Methods and Findings
   Fifty-one case male participants (CIMT >= 0.9 mm) were enrolled during their visits to Korean Genomic Rural Cohort Study of Wonju centers between May 1 and August 31, 2011, along with 51 control participants (CIMT < 0.9 mm) selected using frequency matching by age group. The levels of oxidative damage markers, 8-hydroxy-20-deoxyquuanosine (8-OHdG), malondialdehyde (MDA), and 8-iso-prostaglandin F2 alpha (Isoprostane), were measured. Conditional logistic regression models were used to evaluate relative relationships between the oxidative damage markers and the risk of high CIMT.
   Results
   The markers of oxidative lipid (Isoprostane and MDA) and DNA (8-OHdG) damage were associated with CIMT after controlling for the conventional risk factors, including age, low density lipoprotein, body mass index, smoking history, alcohol consumption, and metabolic syndrome (ORs [95% CI] for Isoprostane: 3rd tertile, 8.47 [2.59-27.67]; for MDA: 3rd tertile, 8.47 [2.59-27.67]; for 8-OHdG: 3rd tertile, 5.58 [1.79-17.33]). When all the oxidative damage markers were incorporated in the same logistic regression model, only Isoprostane was significantly related to CIMT (OR [95% CI]: 4.22 [1.31-13.53] in 2nd tertile and 14.21 [3.34-60.56] in 3rd tertile).
   Conclusions
   In this nested case-control study, the oxidative damage markers of lipid and DNA were associated with CIMT even after controlling for the conventional risk factors of cardiovascular diseases.
C1 [Yoon, Jin-Ha; Park, Jong-Ku; Ko, Sang-Baek] Yonsei Univ, Wonju Coll Med, Dept Prevent Med, Wonju, South Korea.
   [Kim, Jang-Young] Yonsei Univ, Wonju Coll Med, Dept Cardiol, Wonju, South Korea.
   [Yoon, Jin-Ha] Yonsei Univ, Coll Med, Inst Occupat Hlth, Seoul, South Korea.
   [Park, Jong-Ku; Ko, Sang-Baek] Yonsei Univ, Inst Genom Cohort, Wonju, South Korea.
C3 Yonsei University; Yonsei University; Yonsei University; Yonsei
   University Health System; Yonsei University
RP Ko, SB (corresponding author), Yonsei Univ, Wonju Coll Med, Dept Prevent Med, Wonju, South Korea.
EM kohhj@yonsei.ac.kr
RI park, jun yeon/GPX-5293-2022; Kim, Nam Hoon/HNS-5794-2023
OI Yoon, Jin-Ha/0000-0003-4198-2955
CR Ari E., 2011, Hemodialysis Int
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NR 34
TC 20
Z9 20
U1 0
U2 5
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAR 25
PY 2015
VL 10
IS 3
AR e0119731
DI 10.1371/journal.pone.0119731
PG 10
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA CE5MO
UT WOS:000351880000037
PM 25806957
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Parati, G
   Ochoa, JE
   Bilo, G
   Mattaliano, P
   Salvi, P
   Kario, K
   Lombardi, C
AF Parati, Gianfranco
   Ochoa, Juan Eugenio
   Bilo, Grzegorz
   Mattaliano, Paola
   Salvi, Paolo
   Kario, Kazuomi
   Lombardi, Carolina
TI Obstructive sleep apnea syndrome as a cause of resistant hypertension
SO HYPERTENSION RESEARCH
LA English
DT Review
DE antihypertensive treatment; cardiovascular risk; continuous positive
   airway pressure treatment; obstructive sleep apnea; resistant
   hypertension
ID POSITIVE AIRWAY PRESSURE; AMBULATORY BLOOD-PRESSURE; INDEPENDENT
   RISK-FACTOR; C-REACTIVE PROTEIN; PROFESSIONAL-EDUCATION-COMMITTEE;
   FOLLOW-UP; CARDIOVASCULAR RISK; PROGNOSTIC VALUE; ARTERIAL STIFFNESS;
   METABOLIC SYNDROME
AB Evidence has consistently supported the association of obstructive sleep apnea syndrome (OSAS) with an increased prevalence of hypertension. It has also been shown that the severity of OSAS is directly correlated with the degree of blood pressure (BP) elevation and that hypertension occurring in subjects with OSAS is more likely to be severe, resistant to antihypertensive treatment and associated with alterations in day-to-night BP changes. Proposed mechanisms for the pathogenesis of OSAS-related hypertension include the activation of the sympathetic nervous system, alterations in autonomic cardiovascular (CV) modulation, the activation of the renin-angiotensin-aldosterone system, endothelial dysfunction, systemic and vascular inflammation, oxidative stress, metabolic abnormalities, arterial stiffness and alterations in cardiac function and structure. Given the adverse prognostic implications of OSAS-related hypertension for CV morbidity and mortality, the confirmation of resistant hypertension by using ambulatory BP monitoring (ABPM) and the identification of alterations in day-to-night BP changes is of the utmost importance to implement more aggressive strategies for achieving BP control. In turn, the proper identification and implementation of specific treatment strategies for OSAS (that is, continuous positive airway pressure) in subjects with resistant hypertension may promote BP control and optimize CV protection. The present paper will review the evidence supporting the association of OSAS with resistant hypertension and the proposed mechanisms for this association. It will also address the role of ABPM in the confirmation of resistant hypertension in subjects with OSAS and whether the proper identification and management of OSAS in subjects with resistant hypertension will improve BP control.
C1 [Parati, Gianfranco] Univ Milano Bicocca, Dept Hlth Sci, Div Cardiovasc Med, Milan, Italy.
   [Parati, Gianfranco; Ochoa, Juan Eugenio; Bilo, Grzegorz; Mattaliano, Paola; Salvi, Paolo; Lombardi, Carolina] S Luca Hosp, Dept Cardiol, IRCCS Ist Auxol Italiano, I-20149 Milan, Italy.
   [Parati, Gianfranco; Ochoa, Juan Eugenio; Bilo, Grzegorz; Mattaliano, Paola; Salvi, Paolo; Lombardi, Carolina] Univ Milano Bicocca, I-20149 Milan, Italy.
   [Ochoa, Juan Eugenio; Mattaliano, Paola] Univ Milano Bicocca, Dept Hlth Sci, Milan, Italy.
   [Kario, Kazuomi] Jichi Med Univ, Sch Med, Div Cardiovasc Med, Dept Med, Shimotsuke, Tochigi, Japan.
C3 University of Milano-Bicocca; IRCCS Istituto Auxologico Italiano;
   University of Milano-Bicocca; University of Milano-Bicocca; Jichi
   Medical University
RP Parati, G (corresponding author), S Luca Hosp, Dept Cardiol, IRCCS Ist Auxol Italiano, Piazza Brescia 20, I-20149 Milan, Italy.
EM gianfranco.parati@unimib.it
RI Lombardi, Carolina/I-9337-2019; Bilo, Grzegorz/J-8694-2016; Lombardi,
   Carolina/ABR-3176-2022; Parati, Gianfranco/K-7151-2016; Salvi,
   Paolo/JWA-2564-2024
OI Bilo, Grzegorz/0000-0002-5104-9176; Lombardi,
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   Parati, Gianfranco/0000-0001-9402-7439; Salvi, Paolo/0000-0001-8663-5426
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NR 143
TC 67
Z9 72
U1 1
U2 25
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0916-9636
EI 1348-4214
J9 HYPERTENS RES
JI Hypertens. Res.
PD JUL
PY 2014
VL 37
IS 7
BP 601
EP 613
DI 10.1038/hr.2014.80
PG 13
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA AK8UO
UT WOS:000338704300001
PM 24804613
OA Bronze
DA 2025-06-11
ER

PT J
AU De Ciuceis, C
   Rossini, C
   Porteri, E
   La Boria, E
   Corbellini, C
   Mittempergher, F
   Di Betta, E
   Petroboni, B
   Sarkar, A
   Agabiti-Rosei, C
   Casella, C
   Nascimbeni, R
   Rezzani, R
   Rodella, LF
   Bonomini, F
   Agabiti-Rosei, E
   Rizzoni, D
AF De Ciuceis, Carolina
   Rossini, Claudia
   Porteri, Enzo
   La Boria, Elisa
   Corbellini, Claudia
   Mittempergher, Francesco
   Di Betta, Ernesto
   Petroboni, Beatrice
   Sarkar, Annamaria
   Agabiti-Rosei, Claudia
   Casella, Claudio
   Nascimbeni, Riccardo
   Rezzani, Rita
   Rodella, Luigi F.
   Bonomini, Francesca
   Agabiti-Rosei, Enrico
   Rizzoni, Damiano
TI Circulating endothelial progenitor cells, microvascular density and
   fibrosis in obesity before and after bariatric surgery
SO BLOOD PRESSURE
LA English
DT Article
DE Hypertension; microcirculation; obesity; remodeling; small arteries
ID SUBCUTANEOUS SMALL ARTERIES; METABOLIC SYNDROME; RESISTANCE ARTERIES;
   ESSENTIAL-HYPERTENSION; VASCULAR FUNCTION; RECEPTOR BLOCKER; SKIN
   CAPILLARIES; STIFFNESS; RAREFACTION; NUMBER
AB It is not known whether, in obesity, the capillary density or the number of circulating endothelial progenitor cells (EPCs) are reduced, or whether fibrosis of small vessels is also present. In addition, possible effects of weight reduction on these parameters have never been evaluated. Therefore, we investigated EPCs and capillary density in 25 patients with severe obesity, all submitted to bariatric surgery, and in 18 normotensive lean subjects and 12 hypertensive lean patients as controls. All patients underwent a biopsy of subcutaneous fat during bariatric surgery. In five patients, a second biopsy was obtained after consistent weight loss, about 1 year later, during a surgical intervention for abdominoplasty. EPCs and capillary density were reduced in obesity, and EPCs were significantly increased after weight reduction. Vascular collagen content was clearly increased in obese patients. No significant difference in vascular collagen was observed between normotensive obese patients and hypertensive obese patients. After pronounced weight reduction, collagen content was nearly normalized. No difference in stress-strain relation was observed among groups or before and after weight loss. In conclusion, our data suggest that microvascular rarefaction occurs in obesity. EPCs were significantly reduced in obese patients. Pronounced weight loss induced by bariatric surgery seems to induce a significant improvement of EPC number, but not of capillary rarefaction. A pronounced fibrosis of subcutaneous small resistance arteries is present in obese patients, regardless of the presence of increased blood pressure values. Consistent weight loss induced by bariatric surgery may induce an almost complete regression of microvascular fibrosis.
C1 [De Ciuceis, Carolina; Rossini, Claudia; Porteri, Enzo; La Boria, Elisa; Corbellini, Claudia; Petroboni, Beatrice; Sarkar, Annamaria; Agabiti-Rosei, Claudia; Agabiti-Rosei, Enrico; Rizzoni, Damiano] Univ Brescia, Dept Clin & Expt Sci, Med Clin, I-25100 Brescia, Italy.
   [Mittempergher, Francesco; Di Betta, Ernesto] Spedali Civili Brescia, Div Gen Surg 1, Brescia, Italy.
   [Casella, Claudio; Nascimbeni, Riccardo] Univ Brescia, Dept Mol & Translat Med, I-25100 Brescia, Italy.
   [Rezzani, Rita; Rodella, Luigi F.; Bonomini, Francesca] Univ Brescia, Dept Clin & Expt Sci, Sect Human Anat, I-25100 Brescia, Italy.
C3 University of Brescia; Hospital Spedali Civili Brescia; University of
   Brescia; University of Brescia
RP Rizzoni, D (corresponding author), Univ Brescia, Dept Clin & Expt Sci, Med Clin, Med Spedali Civili Brescia 2A, Piazza Spedali Civili 1, I-25100 Brescia, Italy.
EM rizzoni@med.unibs.it
RI Rizzoni, Damiano/E-9967-2010; Francesca, Bonomini/E-9931-2010; CASELLA,
   CLAUDIO/E-7793-2010; Rodella, Luigi/F-1079-2010; De Ciuceis,
   Carolina/AAC-6678-2022
OI Agabiti Rosei, Claudia/0000-0002-9664-2408; Bonomini,
   Francesca/0000-0001-7210-0308; Rodella, Luigi
   Fabrizio/0000-0002-9497-4708
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NR 53
TC 33
Z9 35
U1 0
U2 4
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0803-7051
EI 1651-1999
J9 BLOOD PRESSURE
JI Blood Pressure
PD JUN
PY 2013
VL 22
IS 3
BP 165
EP 172
DI 10.3109/08037051.2012.749584
PG 8
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 142OP
UT WOS:000318807100007
PM 23286244
DA 2025-06-11
ER

PT J
AU Alam, MA
   Sernia, C
   Brown, L
AF Alam, Md Ashraful
   Sernia, Conrad
   Brown, Lindsay
TI Ferulic Acid Improves Cardiovascular and Kidney Structure and Function
   in Hypertensive Rats
SO JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
LA English
DT Article
DE ferulic acid; hypertension; fibrosis; oxidative stress; rats
ID INDUCED METABOLIC SYNDROME; NAME-INDUCED HYPERTENSION; NITRIC-OXIDE;
   BLOOD-PRESSURE; MAST-CELLS; SUPEROXIDE-DISMUTASE; HIGH-CARBOHYDRATE;
   HEME OXYGENASE-1; SODIUM FERULATE; RENAL INJURY
AB Ferulic acid is a simple phenolic acid commonly present in cereals. In this study, changes in heart and kidney structure and function were measured in young N-omega-nitro-L-arginine methyl ester (L-NAME)-treated Wistar rats and 10-month-old spontaneously hypertensive rats (SHR) alone and after chronic treatment with ferulic acid (FA; 50 mg.kg(-1).d(-1); n = 6-10; *P < 0.05). Systolic blood pressures were increased after L-NAME treatment (control 125 +/- 2 mm Hg, L-NAME 205 +/- 6* mm Hg after 8 weeks) and in SHR (250 +/- 2 mm Hg; WKY 149 +/- 4 mm Hg). Hypertensive rats developed left ventricular hypertrophy, increased ventricular diastolic stiffness (kappa; Wistar, 21.4 +/- 1.6; L-NAME, 30.1 +/- 0.9*; WKYs, 24.1 +/- 0.9; SHR 29.5 +/- 0.7) and fibrosis of heart and kidneys. Treatment with ferulic acid reduced systolic blood pressure (L-NAME + FA, 157 +/- 4*; SHR + FA 214 +/- 8* mm Hg), reduced left ventricular diastolic stiffness (L-NAME + FA, 25.2 +/- 0.5*; SHR + FA 26.3 +/- 0.5*) and attenuated inflammatory cell infiltration, ferric iron accumulation, and collagen deposition in left ventricles and kidneys. Ferulic acid improved both endothelium-dependent relaxation in isolated thoracic aortic rings and antioxidant status by increasing superoxide dismutase and catalase activity in the heart and kidneys. FA decreased plasma liver enzyme activities and plasma creatinine concentrations. Thus, FA improved the structure and function of the heart, blood vessels, liver, and kidneys in hypertensive rats.
C1 [Alam, Md Ashraful; Sernia, Conrad] Univ Queensland, Sch Biomed Sci, Brisbane, Qld 4072, Australia.
   [Brown, Lindsay] Univ So Queensland, Dept Biol & Phys Sci, Toowoomba, Qld 4350, Australia.
C3 University of Queensland; University of Southern Queensland
RP Brown, L (corresponding author), Univ So Queensland, Dept Biol & Phys Sci, Toowoomba, Qld 4350, Australia.
EM lindsay.brown@usq.edu.au
RI Alam, Ashraful/G-1964-2014
OI Alam, Md Ashraful/0000-0001-7596-5868
FU Islamic Development Bank Three Years merit PhD Scholarship; UQIRTA;
   Prince Charles Hospital Foundation, Brisbane, Qld, Australia
FX Md. A. Alam is supported by Islamic Development Bank Three Years merit
   PhD Scholarship and UQIRTA.This project was partially funded by The
   Prince Charles Hospital Foundation, Brisbane, Qld, Australia.
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NR 51
TC 126
Z9 141
U1 0
U2 39
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0160-2446
EI 1533-4023
J9 J CARDIOVASC PHARM
JI J. Cardiovasc. Pharmacol.
PD MAR
PY 2013
VL 61
IS 3
BP 240
EP 249
DI 10.1097/FJC.0b013e31827cb600
PG 10
WC Cardiac & Cardiovascular Systems; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Pharmacology & Pharmacy
GA 104JG
UT WOS:000315988200010
PM 23188120
DA 2025-06-11
ER

PT J
AU Cusi, K
AF Cusi, Kenneth
TI Role of Obesity and Lipotoxicity in the Development of Nonalcoholic
   Steatohepatitis: Pathophysiology and Clinical Implications
SO GASTROENTEROLOGY
LA English
DT Review
DE Insulin Resistance; NAFLD; Fatty Liver; Type 2 Diabetes Mellitus
ID FATTY LIVER-DISEASE; INDUCED INSULIN-RESISTANCE; STELLATE CELL
   ACTIVATION; LIFE-STYLE INTERVENTION; RANDOMIZED CONTROLLED-TRIAL;
   PLACEBO-CONTROLLED TRIAL; JUN NH2-TERMINAL KINASE; HEPATIC STEATOSIS;
   ADIPOSE-TISSUE; NATURAL-HISTORY
AB As obesity reaches epidemic proportions, nonalcoholic fatty liver disease (NAFLD) is becoming a frequent cause of patient referral to gastroenterologists. There is a close link between dysfunctional adipose tissue in NAFLD and common conditions such as metabolic syndrome, type 2 diabetes mellitus, and cardiovascular disease. This review focuses on the pathophysiology of interactions between adipose tissue and target organs in obesity and the resulting clinical implications for the management of nonalcoholic steatohepatitis. The release of fatty acids from dysfunctional and insulin-resistant adipocytes results in lipotoxicity, caused by the accumulation of triglyceride-derived toxic metabolites in ectopic tissues (liver, muscle, pancreatic beta cells) and subsequent activation of inflammatory pathways, cellular dysfunction, and lipoapoptosis. The cross talk between dysfunctional adipocytes and the liver involves multiple cell populations, including macrophages and other immune cells, that in concert promote the development of lipotoxic liver disease, a term that more accurately describes the pathophysiology of nonalcoholic steatohepatitis. At the clinical level, adipose tissue insulin resistance contributes to type 2 diabetes mellitus and cardiovascular disease. Treatments that rescue the liver from lipotoxicity by restoring adipose tissue insulin sensitivity (eg, significant weight loss, exercise, thiazolidinediones) or preventing activation of inflammatory pathways and oxidative stress (ie, vitamin E, thiazolidinediones) hold promise in the treatment of NAFLD, although their long-term safety and efficacy remain to be established. Better understanding of pathways that link dysregulated adipose tissue, metabolic dysfunction, and liver lipotoxicity will result in improvements in the clinical management of these challenging patients.
C1 Univ Florida, Div Endocrinol Diabet & Metab, Gainesville, FL 32610 USA.
C3 State University System of Florida; University of Florida
RP Cusi, K (corresponding author), Univ Florida, Div Endocrinol Diabet & Metab, 1600 SW Archer Rd,Room H-2, Gainesville, FL 32610 USA.
EM kenneth.cusi@medicine.ufl.edu
RI Cusi, Kenneth/ADV-2401-2022
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NR 253
TC 686
Z9 741
U1 1
U2 131
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0016-5085
EI 1528-0012
J9 GASTROENTEROLOGY
JI Gastroenterology
PD APR
PY 2012
VL 142
IS 4
BP 711
EP U109
DI 10.1053/j.gastro.2012.02.003
PG 21
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 919BU
UT WOS:000302296400019
PM 22326434
DA 2025-06-11
ER

PT J
AU Kalgaonkar, S
   Nishioka, H
   Gross, HR
   Fujii, H
   Keen, CL
   Hackman, RM
AF Kalgaonkar, Swati
   Nishioka, Hiroshi
   Gross, Heidrun R.
   Fujii, Hajime
   Keen, Carl L.
   Hackman, Robert M.
TI Bioactivity of a Flavanol-rich Lychee Fruit Extract in Adipocytes and
   Its Effects on Oxidant Defense and Indices of Metabolic Syndrome in
   Animal Models
SO PHYTOTHERAPY RESEARCH
LA English
DT Article
DE polyphenol; flavanol; antioxidant; lipids; reactive oxygen species
ID GREEN TEA POLYPHENOL; INHIBITS ADIPOGENESIS; 3T3-L1 CELLS; COCOA;
   DIFFERENTIATION; APOPTOSIS; OLIGONOL; OBESITY
AB Many polyphenolic compounds are poorly digested. and have low bioavailability due to their long chain lengths and chemical composition. A processed. flavanol-rich lychee fruit extract (FRLFE) that is higher in flavanol monomers, dimer and trimers than its unprocessed counterpart, was tested in a variety of models. First. mature visceral adipocytes were treated with 0, 3, 10 or 30 mu g/mL FRLFE (day 6-8). Compared with the controls, the treated cells had lower triglyceride concentrations, less lipid accumulation and a smaller lipid droplet size. Adiponectin release was significantly greater in cells receiving 3 or 10 mu g/mL FRLFE than in the controls. Second, rats given a single dose of 50 or 100 mg/kg FRLFE had significant increases in plasma (-)-epicatechin, 3'-O-methyl-(-)-epicatechin, and (+)-catechin levels, peak values were at approximately 2 h and appreciable concentrations were still detected at 6 h. Rats supplemented daily for 1 week with 50 or 100 mg/kg FRLFE had significantly elevated metabolite concentrations. In response to an oxidative stress, erythrocyte membrane integrity was significantly improved in the 100 mg/kg FRLFE group. Third, 7-month-old mice fed a 200 mg/kg FRLFE diet for 10 months showed a significant decrease in glucose, triglyceride and lipid peroxide levels compared with mice fed a control diet. Collectively, these results support the concept that the flavanols present in FRLFE are well absorbed and bioactive. Copyright (C) 2010 John Wiley & Sons, Ltd.
C1 [Kalgaonkar, Swati; Gross, Heidrun R.; Keen, Carl L.; Hackman, Robert M.] Univ Calif Davis, Dept Nutr, Davis, CA 95616 USA.
   [Nishioka, Hiroshi; Fujii, Hajime] Amino Up Chem Co Ltd, Sapporo, Hokkaido, Japan.
C3 University of California System; University of California Davis
RP Hackman, RM (corresponding author), Univ Calif Davis, Dept Nutr, 1 Shields Ave, Davis, CA 95616 USA.
FU Amino Up Chemical Co, Ltd; UC Davis Center for Health and Nutrition
   Research; State of California Vitamin Price Fixing Settlement Fund
FX We gratefully acknowledge Sonia Shenoy for her editorial advice This
   study was partially funded by an unrestricted gift from Amino Up
   Chemical Co, Ltd, and by the UC Davis Center for Health and Nutrition
   Research. established with funding from the State of California Vitamin
   Price Fixing Settlement Fund
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NR 31
TC 13
Z9 13
U1 0
U2 12
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0951-418X
EI 1099-1573
J9 PHYTOTHER RES
JI Phytother. Res.
PD AUG
PY 2010
VL 24
IS 8
BP 1223
EP 1228
DI 10.1002/ptr.3137
PG 6
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 639WG
UT WOS:000281006500019
PM 20309950
DA 2025-06-11
ER

PT J
AU Ghanim, H
   Abuaysheh, S
   Sia, CL
   Korzeniewski, K
   Chaudhuri, A
   Fernandez-Real, JM
   Dandona, P
AF Ghanim, Husam
   Abuaysheh, Sanaa
   Sia, Ching Ling
   Korzeniewski, Kelly
   Chaudhuri, Ajay
   Fernandez-Real, Jose Manuel
   Dandona, Paresh
TI Increase in Plasma Endotoxin Concentrations and the Expression of
   Toll-like Receptors and Suppressor of Cytokine Signaling-3 in
   Mononuclear Cells After a High-Fat, High-Carbohydrate Meal Implications
   for insulin resistance
SO DIABETES CARE
LA English
DT Article
ID FACTOR-KAPPA-B; PROINFLAMMATORY STATE; METABOLIC SYNDROME;
   ADIPOSE-TISSUE; OBESE SUBJECTS; INFLAMMATION; ACTIVATION; SENSITIVITY;
   MONOCYTES; MICE
AB OBJECTIVE - To compare the effect of a high-fat, high-carbohydrate meal (HFHC) with that of a high-fiber and fruit meal on the concentrations of endotoxin (lipopolysaccharide vertical bar LPS vertical bar), LPS-binding protein (LBP), the expression of toll-like receptors (TLRs), and the Suppressor of cytokine signaling-3 (SOCS-3) in mononuclear cells.
   RESEARCH DESIGN AND METHODS - Healthy lean subjects were given 9 10 calories Of either an HFHC meal (n = 10) or an American Heart Association (AHA)-recommended meal rich in fiber and fruit (n = 10) after an overnight fast. Blood was collected before and at 1, 2, and 3 h after the meal. Cellular indexes of oxidative and inflammatory stress; the expression of SOCS-3, TLR2, and TLR4 in mononuclear cells; and plasma concentrations of LPS and LBP were measured.
   RESULTS - HFHC meal intake induced an increase in plasma LPS concentration and the expression of SOCS-3, TLR2, and TLR4 protein, reactive oxygen species generation, and nuclear factor-kappa B binding activity (P < 0.05 for all). These increases were totally absent after the AHA meal rich in fiber and fruit.
   CONCLUSIONS - The novel changes described after the HFHC meal elucidate further the mechanisms underlying postprandial inflammation and also provide the first evidence explaining the pathogenesis of insulin and leptin resistance mediated by SOCS-3 after such meals. In contrast, an AHA meal does not induce these effects.
C1 [Ghanim, Husam; Abuaysheh, Sanaa; Sia, Ching Ling; Korzeniewski, Kelly; Fernandez-Real, Jose Manuel; Dandona, Paresh] SUNY Buffalo, Div Endocrinol Diabet & Metab, Buffalo, NY 14260 USA.
   [Ghanim, Husam; Abuaysheh, Sanaa; Sia, Ching Ling; Korzeniewski, Kelly; Fernandez-Real, Jose Manuel; Dandona, Paresh] Kaleida Hlth, Buffalo, NY USA.
   [Chaudhuri, Ajay] Minist Sci, CIBERobn Fisiopatol Obesidad & Nutr, Hosp Girona, Biomed Res Inst Girona, Girona, Spain.
C3 State University of New York (SUNY) System; University at Buffalo, SUNY;
   Kaleida Health; CIBER - Centro de Investigacion Biomedica en Red;
   CIBEROBN; Universitat de Girona; Girona University Hospital Dr. Josep
   Trueta; Institut d'Investigacio Biomedica de Girona (IDIBGI)
RP Dandona, P (corresponding author), SUNY Buffalo, Div Endocrinol Diabet & Metab, Buffalo, NY 14260 USA.
EM pdandona@kaleidahealth.org
RI Fernández-Real, Jose Manuel/AGH-3599-2022
OI Fernandez-Real, Jose Manuel/0000-0002-7442-9323
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NR 24
TC 405
Z9 450
U1 1
U2 35
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0149-5992
EI 1935-5548
J9 DIABETES CARE
JI Diabetes Care
PD DEC
PY 2009
VL 32
IS 12
BP 2281
EP 2287
DI 10.2337/dc09-0979
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 532YH
UT WOS:000272786600026
PM 19755625
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Haensel, A
   Mills, PJ
   Nelesen, RA
   Ziegler, MG
   Dimsdale, JE
AF Haensel, Alexander
   Mills, Paul J.
   Nelesen, Richard A.
   Ziegler, Michael G.
   Dimsdale, Joel E.
TI The relationship between heart rate variability and inflammatory markers
   in cardiovascular diseases
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Review
DE Autonomic nervous system; Vagal nerve; Heart rate variability; Coronary
   heart disease; Inflammation
ID C-REACTIVE PROTEIN; NECROSIS-FACTOR-ALPHA; CHIMERIC MONOCLONAL-ANTIBODY;
   MYOCARDIAL-INFARCTION; MENTAL STRESS; VAGUS NERVE; CORONARY;
   INTERLEUKIN-6; ACTIVATION; FIBRINOGEN
AB Introduction: Recent evidence implicates a cholinergic anti-inflammatory pathway. Because vagus nerve activity mediates some heart rate variability (HRV), this qualitative review examines the literature concerning circulating cytokines and HRV in cardiovascular function in humans. This qualitative review examines the literature concerning circulating cytokines and HRV in cardiovascular function in humans.
   Methods: Thirteen studies on HRV, inflammation, and cardiovascular function were located by electronic library search and descriptively reviewed.
   Results: The relationship between HRV and inflammation was studied in healthy controls, patients with acute or stable coronary heart disease (CHD), patients with metabolic syndrome or impaired glucose tolerance and patients with kidney failure. Investigations focused mainly on Interleukin-6 (IL-6) and C-reactive peptide (CRP). The majority of reviewed studies reported that parasympathetic nervous system tone as inferred from heart rate variability is inversely related to inflammatory markers (r values between -0.2 and -0.4). The relationships with inflammatory markers were similar whether derived from ECG signals as short as 5-30 min or from 24-h ECG readings for HRV analyses. While inflammatory markers appear to be related to HRV, it is a mistake to assume that the traditional "vagal measures" of HRV (such as high frequency heart rate variability) are the driving factors. Indeed, tow frequency heart rate variability, a complex measure reflecting both parasympathetic and sympathetic activity, is the more commonly associated measure linked to inflammatory markers.
   Discussion: Heart rate variability is inversely correlated with inflammatory markers in healthy individuals as well as in those with cardiovascular diseases. Published by Elsevier B.V.
C1 [Haensel, Alexander] Univ Hosp Bern, Dept Gen Internal Med, Inselspital, CH-3010 Bern, Switzerland.
   [Haensel, Alexander; Mills, Paul J.; Nelesen, Richard A.; Dimsdale, Joel E.] Univ Calif San Diego, Dept Psychiat, San Diego, CA 92103 USA.
   [Ziegler, Michael G.; Dimsdale, Joel E.] Univ Calif San Diego, Dept Med, San Diego, CA 92103 USA.
C3 University of Bern; University Hospital of Bern; University of
   California System; University of California San Diego; University of
   California System; University of California San Diego
RP Haensel, A (corresponding author), Univ Hosp Bern, Dept Gen Internal Med, Inselspital, CH-3010 Bern, Switzerland.
EM Alexander.haensel@insel.ch
RI Ziegler, Michael/L-4728-2019
FU NIH [HL44915, HL36005, RR00827, CA23100]; Swiss National Foundation
   [PBBSB115117]
FX This work was supported by NIH grants HL44915, HL36005, RR00827, CA23100
   and by the grant PBBSB115117 from the Swiss National Foundation.
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NR 43
TC 210
Z9 234
U1 1
U2 26
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
EI 1873-3360
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD NOV
PY 2008
VL 33
IS 10
BP 1305
EP 1312
DI 10.1016/j.psyneuen.2008.08.007
PG 8
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA 385ZY
UT WOS:000261853300001
PM 18819754
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Medina-Navarro, R
   Guzman-Grenfell, AM
   Diaz-Flores, M
   Duran-Reyes, G
   Ortega-Camarillo, C
   Olivares-Corichi, IM
   Hicks, JJ
AF Medina-Navarro, Rafael
   Guzman-Grenfell, Alberto M.
   Diaz-Flores, Margarita
   Duran-Reyes, Genoveva
   Ortega-Camarillo, Clara
   Olivares-Corichi, Ivonne M.
   Hicks, Juan Jose
TI Formation of an adduct between insulin and the toxic lipoperoxidation
   product acrolein decreases both the hypoglycemic effect of the hormone
   in rat and glucose uptake in 3T3 Adipocytes
SO CHEMICAL RESEARCH IN TOXICOLOGY
LA English
DT Article
ID OXIDATIVE STRESS; METABOLIC SYNDROME; DIABETES-MELLITUS; CROSS-LINKING;
   IN-VITRO; PROTEINS; INVOLVEMENT; MECHANISM; TRANSPORT
AB Lipid peroxidation induced by reactive oxygen species might modify circulating biomolecules because of the formation of alpha,beta-unsaturated or dicarbonylic aldehydes. In order to investigate the interaction between a lipoperoxidation product, acrolein, and a circulating protein, insulin, the acrolein-insulin adduct was obtained. To characterize the adduct, gel filtration chromatography, sodium dodecylsulfate-poly-acrylamide gel electrophoresis and carbonyl determination were performed. Induction of hypoglycemia in the rat and stimulation of glucose uptake by 3T3 adipocytes were used to evaluate the biological efficiency of the adduct compared with that of native insulin (Mackness, B., Quarck, R., Verte, W., Mackness, M., and Holvoet, P. (2006) Arterioscler., Thromb. Vasc. Biol. 26, 1545-1550). Formation of the acrolein-insulin complex in vitro increased the carbonyl group concentration from 2.5 to 22.5 nmol/ mg of protein, and it formed without intermolecular aggregates (Halliwell, B., and Whiteman, M. (2004) Br. J. Pharmacol. 142, 231-255. The hypoglycaemic effect 18 min after administration to the rat is decreased by 25% (Robertson, R. P. (2004) J. Biol. Chem. 279, 42351-42354. An adduct concentration of 94 nM, compared to 10 nM for native insulin, was required to obtain the A(50%) (concentration needed to obtain 50% of maximum transport of glucose uptake by 3T3 adipocytes). In conclusion, formation of the acrolein-insulin adduct modifies the structure of insulin and decreases its hypoglycemic effect in rat and glucose uptake by 3T3 adipocytes. These results help explain how a toxic aldehyde prone to be produced in vivo can structurally modify insulin and change its biological action.
C1 Ctr Invest Biomed Michoacan, Inst Mexicano Seguro Social, Lab Metabolismo Expt, Michoacan, Mexico.
   Inst Nacl Enfermedades Respiratorias Ismael Cosio, Dept Invest Bioquim & Med Ambiental, Mexico City, DF, Mexico.
   Ctr Med Nacl Siglo XXI, Inst Mexicano Seguro Social, Mexico City, DF, Mexico.
   Inst Politecn Nacl, Escuela Med Superior Med, Sect Invest & Postgrado, Mexico City, DF, Mexico.
C3 Instituto Mexicano del Seguro Social; Instituto Mexicano del Seguro
   Social; Instituto Politecnico Nacional - Mexico
RP Hicks, JJ (corresponding author), Ctr Invest Biomed Michoacan, Inst Mexicano Seguro Social, Lab Metabolismo Expt, Michoacan, Mexico.
EM jhicks@iner.gob.mx
RI Ortega, Clara/MSZ-8179-2025
OI ORTEGA CAMARILLO, CLARA/0000-0001-8709-6727; Olivares Corichi, Ivonne
   Maria/0000-0002-5608-048X; DIAZ-FLORES, MARGARITA/0000-0001-9764-2701;
   Medina-Navarro, Rafael/0000-0002-7183-6126
CR [Anonymous], AM J CLIN NUTR
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NR 35
TC 8
Z9 9
U1 0
U2 4
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0893-228X
J9 CHEM RES TOXICOL
JI Chem. Res. Toxicol.
PD OCT
PY 2007
VL 20
IS 10
BP 1477
EP 1481
DI 10.1021/tx7001355
PG 5
WC Chemistry, Medicinal; Chemistry, Multidisciplinary; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Chemistry; Toxicology
GA 221AB
UT WOS:000250197600012
PM 17803267
DA 2025-06-11
ER

PT J
AU Pandey, NR
   Benkirane, K
   Amiri, F
   Schiffrin, EL
AF Pandey, Nihar R.
   Benkirane, Karim
   Amiri, Farhad
   Schiffrin, Ernesto L.
TI Effects of PPAR-γ knock-down and hyperglycemia on insulin signaling in
   vascular smooth muscle cells from hypertensive rats
SO JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
LA English
DT Article
DE hypertension; PPAR-gamma siRNA; GLUT-4; GSK-3 beta; glucose metabolism
ID ACTIVATED RECEPTOR-ALPHA; TYROSINE-PHOSPHATASE 1B; DIABETIC
   COMPLICATIONS; DEPENDENT HYPERTENSION; METABOLIC SYNDROME; OXIDATIVE
   STRESS; SKELETAL-MUSCLE; ADIPOSE-TISSUE; PROTEIN-KINASE; EXPRESSION
AB Peroxisome proliterator-activated receptor (PPAR)-gamma, a target in the treatment of diabetes, improves insulin sensitivity and exerts cardiovascular protective effects by mechanisms that are not completely elucidated. To investigate underlying molecular mechanisms responsible for PPAR-gamma-associated vascular insulin signaling in hypertension, we tested whether PPAR-gamma downregulation in vascular smooth muscle cells (VSMC) from WKY and SHRSP rats would decrease insulin signaling and glucose uptake and whether this response would be worsened by hyperglycemia to a greater extent in VSMC of hypertensive origin. Passaged mesenteric artery VSMC grown in euglycemic (5.5 mmol/L) or hyperglycemic media (25.0 mmol/L) were treated with PPAR-gamma-siRNA (5 nmol/L), PPAR-gamma antagonist (GW-9662, 10 mu mol/L), or PPAR-gamma activator (rosiglitazone, 10 mu mol/L) in the presence or absence of insulin (100 nmol/L). Immunoblotting revealed that hyperglycemia and PPAR-gamma inhibition significantly (P < 0.001) decreased insulin-stimulated insulin receptor (IR)-beta, Akt, and glycogen synthase kinase (GSK)-3 beta phosphorylation, whereas phosphotyrosine phosphatase (PTP)-1B expression was increased in VSMC from both strains. These effects were more pronounced in SHRSP under hyperglycemia. Rosiglitazone tended to increase insulin-mediated IR-beta, Akt, and GSK-3 beta phosphorylation in VSMC from both strains, whereas insulin-induced PTP-1B expression was reduced by hyperglycemia. Insulin-stimulated GLUT-4 expression and glucose transport were attenuated by hyperglycemia in both VSMC. These data suggest that PPAR-gamma inhibition results in decreased insulin signaling, particularly in SHR, in an IR-beta phosphorylation-dependent manner.
C1 Sir Mortimer B Davis Jewish Hosp, Davis Inst Med Res, Hypertens & Vasc Res Unit, Montreal, PQ H3T 1E2, Canada.
C3 Jewish General Hospital - Montreal
RP Schiffrin, EL (corresponding author), Sir Mortimer B Davis Jewish Hosp, Davis Inst Med Res, Hypertens & Vasc Res Unit, 3755 Cote Ste Catherine Rd,B-127, Montreal, PQ H3T 1E2, Canada.
EM ernesto.schiffrin@mcgill.ca
RI Schiffrin, Ernesto/AAB-9061-2019; Amiri, Farhad/LUZ-5182-2024
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NR 38
TC 13
Z9 19
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0160-2446
J9 J CARDIOVASC PHARM
JI J. Cardiovasc. Pharmacol.
PD JUN
PY 2007
VL 49
IS 6
BP 346
EP 354
DI 10.1097/FJC.0b013e31804654d7
PG 9
WC Cardiac & Cardiovascular Systems; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Pharmacology & Pharmacy
GA 185CI
UT WOS:000247688500002
PM 17577098
OA Bronze
DA 2025-06-11
ER

PT J
AU Okumura, K
   Ikejima, K
   Kon, K
   Abe, W
   Yamashina, S
   Enomoto, N
   Takei, Y
   Sato, N
AF Okumura, Kyoko
   Ikejima, Kenichi
   Kon, Kazuyoshi
   Abe, Wataru
   Yamashina, Shunhei
   Enomoto, Nobuyuki
   Takei, Yoshiyuki
   Sato, Nobuhiro
TI Exacerbation of dietary steatohepatitis and fibrosis in obese, diabetic
   KK-A<SUP>y</SUP> mice
SO HEPATOLOGY RESEARCH
LA English
DT Article
DE non-alcoholic steatohepatitis (NASH); methionine- and choline-deficiency
   (MCD); oxidative stress; hepatic fibrogenesis; leptin; adiponectin
ID NONALCOHOLIC FATTY LIVER; HEPATIC STELLATE CELLS; BODY-MASS INDEX;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; MURINE LIVER; RISK-FACTOR; OB/OB
   MICE; LEPTIN; DISEASE
AB In this study, we investigated a dietary model of steatohepatitis caused by methionine- and choline-deficiency (MCD) in obese, diabetic KK-A(y) mice. Male KK-A(y) mice and C57Bl/6 mice were fed an MCD diet for up to 8 weeks, and liver pathology was evaluated. Hepatic steatosis and inflammatory infiltration were more prominent in KK-A(y) mice than in C57Bl/6 mice 4 weeks after feeding with MCD diet. MCD diet-induced increases in tumor necrosis factor (TNF)-alpha mRNA levels, as well as lipid peroxidation, in the liver were also potentiated significantly in KK-A(y) mice. Extended degree of hepatic fibrosis was observed in KK-A(y) mice as compared to C57Bl/6 mice 8 weeks after feeding with MCD diet. Indeed, alpha 1(I) procollagen and transforming growth factor (TGF)-beta 1 mRNA levels were significantly higher in KK-A(y) mice following dietary treatment. Serum adiponectin levels were elevated nearly two-fold when C57Bl/6 mice were given MCD diet for 4 weeks; however, serum adiponectin levels in KK-A(y) mice fed both the control- and MCD diet were the same, reaching the values almost 1/2 of those in C57Bl/6 mice. In conclusion, KK-A(y) mice exhibit increased susceptibility to MCD diet-induced steatohepatitis, where hypoadiponectinemia most likely plays a key role in exacerbation of both inflammatory and profibrogenic responses. c 2006 Elsevier Ireland Ltd. All rights reserved.
C1 Juntendo Univ, Sch Med, Dept Gastroenterol, Bunkyo Ku, Tokyo 113, Japan.
C3 Juntendo University
RP Ikejima, K (corresponding author), Juntendo Univ, Sch Med, Dept Gastroenterol, Bunkyo Ku, 2-1-1 Hongo, Tokyo 113, Japan.
EM ikejima@med.juntendo.ac.jp
RI Sato, Nobuhiro/AAA-3457-2020; Kon, Kazuyoshi/AAV-7832-2020
OI Kon, Kazuyoshi/0000-0002-1127-2218
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NR 44
TC 43
Z9 45
U1 0
U2 2
PU BLACKWELL PUBLISHING
PI OXFORD
PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND
SN 1386-6346
J9 HEPATOL RES
JI Hepatol. Res.
PD NOV
PY 2006
VL 36
IS 3
BP 217
EP 228
DI 10.1016/j.hepres.2006.07.009
PG 12
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 198GV
UT WOS:000248615900011
PM 16920398
DA 2025-06-11
ER

PT J
AU Liu, HM
   Wang, H
   Lin, XY
   Xu, M
   Lan, WY
   Wang, JL
AF Liu, Hongmei
   Wang, Huan
   Lin, Xinyu
   Xu, Min
   Lan, Wenying
   Wang, Jinlian
TI Harnessing natural saponins: Advancements in mitochondrial dysfunction
   and therapeutic applications
SO PHYTOMEDICINE
LA English
DT Article
DE Saponins; Mitochondrial dysfunction; Therapeutic potential;
   Bioavailability; Natural product
ID OXIDATIVE STRESS; TRITERPENOID SAPONIN; CANCER-CELLS; IN-VITRO;
   APOPTOSIS; DIAGNOSIS; DEATH; PHARMACOKINETICS; PATHOPHYSIOLOGY;
   MECHANISMS
AB Background: Mitochondrial dysfunction plays a crucial role in the development of a variety of diseases, notably neurodegenerative disorders, cardiovascular diseases, metabolic syndrome, and cancer. Natural saponins, which are intricate glycosides characterized by steroidal or triterpenoid structures, have attracted interest due to their diverse pharmacological benefits, including anti-inflammatory, antiviral, and anti-aging effects. Purpose: This review synthesizes recent advancements in understanding mitochondrial dysfunction and explores how saponins can modulate mitochondrial function. It focuses on their potential applications in neuroprotection, cardiovascular health, and oncology. Study design: The review incorporates a comprehensive literature analysis, highlighting the interplay between saponins and mitochondrial signaling pathways. Specific attention is given to the effects of saponins like ginsenoside Rg2 and 20(S)-protopanaxatriol on mitophagy and their neuroprotective, anti-aging, and synergistic therapeutic effects when combined. Methods: We conducted a comprehensive review of current research and clinical trials using PubMed, Google Scholar, and SciFinder databases. The search focused on saponins' role in mitochondrial function and their therapeutic effects, including "saponins", "mitochondria" and "mitochondrial function". The analysis primarily focused on articles published between 2011 and 2024. Results: The findings indicate that certain saponins can enhance mitophagy and modulate mitochondrial signaling pathways, showing promise in neuroprotection and anti-aging. Additionally, combinations of saponins have demonstrated synergistic effects in myocardial protection and cancer therapy, potentially improving therapeutic outcomes. Conclusion: Although saponins exhibit significant potential in modulating mitochondrial functions and developing innovative therapeutic strategies, their clinical applications are constrained by low bioavailability. Rigorous clinical trials are essential to translate these findings into effective clinical therapies, ultimately improving patient outcomes through a deeper understanding of saponins' impact on mitochondrial function.
C1 [Liu, Hongmei; Xu, Min] Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Dept Pharm, Chengdu 610000, Sichuan, Peoples R China.
   [Liu, Hongmei; Xu, Min] Southwest Jiaotong Univ, Peoples Hosp Chengdu 3, Affiliated Hosp, Dept Pharm, Chengdu 610000, Sichuan, Peoples R China.
   [Wang, Jinlian] Tradit Chinese Med Hosp Meishan, Meishan 620010, Peoples R China.
   [Wang, Huan; Lin, Xinyu; Lan, Wenying] Chengdu Univ Tradit Chinese Med, Sch Pharm, Chengdu 611137, Peoples R China.
C3 University of Electronic Science & Technology of China; Sichuan
   Provincial People's Hospital; Southwest Jiaotong University; Chengdu
   University of Traditional Chinese Medicine
RP Wang, JL (corresponding author), Tradit Chinese Med Hosp Meishan, Meishan 620010, Peoples R China.
EM 18408203955@163.com
RI Xu, Min/MIK-0060-2025; wang, jinlian/G-4748-2016
FU National Natural Science Foundation of China [8230141573, 82304969];
   Science & Technology Department of Sichuan Province [2024ZYD0105]
FX We are grateful for financial support from National Natural Science
   Foundation of China (8230141573 and 82304969) and Science & Technology
   Department of Sichuan Province (2024ZYD0105) . Some figures were
   partially created with "BioRender.com ".
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NR 170
TC 1
Z9 1
U1 12
U2 12
PU ELSEVIER GMBH
PI MUNICH
PA HACKERBRUCKE 6, 80335 MUNICH, GERMANY
SN 0944-7113
EI 1618-095X
J9 PHYTOMEDICINE
JI Phytomedicine
PD MAR
PY 2025
VL 138
AR 156383
DI 10.1016/j.phymed.2025.156383
EA JAN 2025
PG 21
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA T8N0N
UT WOS:001407494000001
PM 39848019
DA 2025-06-11
ER

PT J
AU Wu, YP
   Zhang, XY
   Sun, L
   Wu, QQ
   Liu, XP
   Deng, YY
   Lu, ZZ
   Li, ZX
   Deng, CM
   He, RK
   Zhang, LY
   Zeng, R
   Zhang, XG
   Chen, LA
   Lin, X
AF Wu, Yanpu
   Zhang, Xinyan
   Sun, Liang
   Wu, Qingqing
   Liu, Xiaoping
   Deng, Yueyi
   Lu, Zhenzhen
   Li, Zhongxia
   Deng, Chaoming
   He, Ruikun
   Zhang, Luyun
   Zeng, Rong
   Zhang, Xuguang
   Chen, Luonan
   Lin, Xu
TI Two-dimensional Health State Map to define metabolic health using
   separated static and dynamic homeostasis features: a proof-of-concept
   study
SO NATIONAL SCIENCE REVIEW
LA English
DT Article
DE metabolic health; two-dimensional; homeostatic resilience
ID PLASMA; PREDICTION
AB Defining metabolic health is critical for the earlier reversing of metabolic dysfunction and disease, and fasting-based diagnosis may not adequately assess an individual's metabolic adaptivity under stress. We constructed a novel Health State Map (HSM) comprising a Health Phenotype Score (HPS) with fasting features alone and a Homeostatic Resilience Score (HRS) with five time-point features only (t = 30, 60, 90, 180, 240 min) following a standardized mixed macronutrient tolerance test (MMTT). Among 111 Chinese adults, when the same set of fasting and post-MMTT data as for the HSM was used, the mixed-score was highly correlated with the HPS. The HRS was significantly associated with metabolic syndrome prevalence, independently of the HPS (OR [95% CI]: 0.41 [0.18, 0.92]) and the mixed-score (0.34 [0.15, 0.69]). Moreover, the HRS could discriminate metabolic characteristics unseparated by the HPS and the mixed-score. Participants with higher HRSs had better metabolic traits than those with lower HRSs. Large interpersonal variations were also evidenced by evaluating postprandial homeostatic resiliencies for glucose, lipids and amino acids when participants had similar overall HRSs. Additionally, the HRS was positively associated with physical activity level and specific gut microbiome structure. Collectively, our HSM model might offer a novel approach to precisely define an individual's metabolic health and nutritional capacity.
   The Health State Map (HSM), which integrates the fasting-based 'Health Phenotype Score (HPS)' and postprandial-based 'Homeostatic Resilience Score (HRS),' offers a superior approach to the 1D mixed-score framework in depicting metabolic health.
C1 [Wu, Yanpu; Sun, Liang; Zhang, Xuguang; Lin, Xu] Chinese Acad Sci, Shanghai Inst Nutr & Hlth, Shanghai 200031, Peoples R China.
   [Wu, Yanpu; Li, Zhongxia; Deng, Chaoming; He, Ruikun; Zhang, Xuguang] Byhealth Inst Nutr & Hlth, Guangzhou 510799, Peoples R China.
   [Zhang, Xinyan; Liu, Xiaoping; Chen, Luonan; Lin, Xu] Univ Chinese Acad Sci, Hangzhou Inst Adv Study, Sch Life Sci, Key Lab Syst Hlth Sci Zhejiang Prov, Hangzhou 310024, Peoples R China.
   [Zhang, Xinyan; Wu, Qingqing; Zeng, Rong; Chen, Luonan] Chinese Acad Sci, Shanghai Inst Biochem & Cell Biol, Ctr Excellence Mol Cell Sci, Key Lab Syst Biol, Shanghai 200031, Peoples R China.
   [Sun, Liang] Fudan Univ, Inst Nutr, Sch Publ Hlth, Dept Nutr & Food Hyg, Shanghai 200032, Peoples R China.
   [Deng, Yueyi; Lu, Zhenzhen; Zhang, Luyun] Shanghai Univ Tradit Chinese Med, Longhua Hosp, Dept Nephrol, Shanghai 200030, Peoples R China.
   [Chen, Luonan] ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China.
C3 Chinese Academy of Sciences; Shanghai Institute of Nutrition & Health,
   CAS; Chinese Academy of Sciences; University of Chinese Academy of
   Sciences, CAS; Chinese Academy of Sciences; Center for Excellence in
   Molecular Cell Science, CAS; Fudan University; Shanghai University of
   Traditional Chinese Medicine; ShanghaiTech University
RP Zhang, XG; Lin, X (corresponding author), Chinese Acad Sci, Shanghai Inst Nutr & Hlth, Shanghai 200031, Peoples R China.; Zhang, XG (corresponding author), Byhealth Inst Nutr & Hlth, Guangzhou 510799, Peoples R China.; Chen, LA; Lin, X (corresponding author), Univ Chinese Acad Sci, Hangzhou Inst Adv Study, Sch Life Sci, Key Lab Syst Hlth Sci Zhejiang Prov, Hangzhou 310024, Peoples R China.; Zeng, R; Chen, LA (corresponding author), Chinese Acad Sci, Shanghai Inst Biochem & Cell Biol, Ctr Excellence Mol Cell Sci, Key Lab Syst Biol, Shanghai 200031, Peoples R China.; Chen, LA (corresponding author), ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China.
EM zr@sibcb.ac.cn; fxgzhang@gmail.com; lnchen@sibcb.ac.cn; xlin@sibs.ac.cn
RI Li, Zhongxia/JNS-8893-2023; , /AAS-8081-2020; liu,
   Xiaoping/F-8791-2013
OI liu, Xiaoping/0000-0002-3246-4227; Wu, Qingqing/0000-0001-8087-2420
FU Chinese Academy of Sciences [XDB38000000]; BYHEALTH Nutrition and Health
   Research Foundation [TY0191114]; Shanghai Municipal Science and
   Technology Major Project [2017SHZDZX01]; Ministry of Science and
   Technology of China [2023YFC2506702, 2023YFC2506704]
FX We thank the graduate students, faculty and staff members in Xu Lin's
   laboratory for conducting the study, as well as the doctors, nurses and
   graduate students in the Department of Nephrology, Longhua Hospital for
   assisting in MMTT and sample collection. We thank Dr. Yan Zheng from
   Fudan University and Dr. Xin Liu from Xi'an Jiaotong University for
   assisting in the gut microbiota analysis. We also want to thank all the
   participants in our study.
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NR 41
TC 0
Z9 0
U1 1
U2 1
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 2095-5138
EI 2053-714X
J9 NATL SCI REV
JI Natl. Sci. Rev.
PD DEC 30
PY 2024
VL 12
IS 1
AR nwae425
DI 10.1093/nsr/nwae425
PG 15
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA R0Y2I
UT WOS:001388807800001
PM 39816947
OA gold
DA 2025-06-11
ER

PT J
AU Li, M
   Cui, M
   Li, GX
   Liu, YQ
   Xu, YS
   Eftekhar, SP
   Ala, M
AF Li, Meng
   Cui, Man
   Li, Guoxia
   Liu, Yueqiu
   Xu, Yunsheng
   Eftekhar, Seyed Parsa
   Ala, Moein
TI The Pathophysiological Associations Between Obesity, NAFLD, and
   Atherosclerotic Cardiovascular Diseases
SO HORMONE AND METABOLIC RESEARCH
LA English
DT Article
DE obesity; cardiovascular diseases; insulin resistance; endothelial
   dysfunction; GLP1 signaling
ID FATTY LIVER-DISEASE; RENIN-ANGIOTENSIN SYSTEM; CONVERTING
   ENZYME-INHIBITORS; GLUCAGON-LIKE PEPTIDE-1; DIET-INDUCED OBESITY;
   DE-NOVO LIPOGENESIS; INSULIN-RESISTANCE; MITOCHONDRIAL DYSFUNCTION;
   ENDOTHELIAL DYSFUNCTION; NONALCOHOLIC STEATOHEPATITIS
AB Obesity, non-alcoholic fatty liver disease (NAFLD), and atherosclerotic cardiovascular diseases are common and growing public health concerns. Previous epidemiological studies unfolded the robust correlation between obesity, NAFLD, and atherosclerotic cardiovascular diseases. Obesity is a well-known risk factor for NAFLD, and both of them can markedly increase the odds of atherosclerotic cardiovascular diseases. On the other hand, significant weight loss achieved by lifestyle modification, bariatric surgery, or medications, such as semaglutide, can concomitantly improve NAFLD and atherosclerotic cardiovascular diseases. Therefore, certain pathophysiological links are involved in the development of NAFLD in obesity, and atherosclerotic cardiovascular diseases in obesity and NAFLD. Moreover, recent studies indicated that simultaneously targeting several mechanisms by tirzepatide and retatrutide leads to greater weight loss and markedly improves the complications of metabolic syndrome. These findings remind the importance of a mechanistic viewpoint for breaking the association between obesity, NAFLD, and atherosclerotic cardiovascular diseases. In this review article, we mainly focus on shared pathophysiological mechanisms, including insulin resistance, dyslipidemia, GLP1 signaling, inflammation, oxidative stress, mitochondrial dysfunction, gut dysbiosis, renin-angiotensin-aldosterone system (RAAS) overactivity, and endothelial dysfunction. Most of these pathophysiological alterations are primarily initiated by obesity. The development of NAFLD further exacerbates these molecular and cellular alterations, leading to atherosclerotic cardiovascular disease development or progression as the final manifestation of molecular perturbation. A better insight into these mechanisms makes it feasible to develop new multi-target approaches to simultaneously unhinge the deleterious chain of events linking obesity and NAFLD to atherosclerotic cardiovascular diseases.
C1 [Li, Meng; Cui, Man; Li, Guoxia; Xu, Yunsheng] Shandong Univ Tradit Chinese Med, Dept Endocrinol, Affiliated Hosp 2, Jinan, Peoples R China.
   [Liu, Yueqiu] Shandong Univ Tradit Chinese Med, Clin Sch Med 1, Clin Specialty Integrated Chinese & Western Med, Jinan, Peoples R China.
   [Eftekhar, Seyed Parsa] Babol Univ Med Sci, Dept Pharmacol, Babol, Iran.
   [Ala, Moein] Univ Tehran Med Sci, Dept Pharmacol, Tehran, Iran.
C3 Shandong University of Traditional Chinese Medicine; Shandong University
   of Traditional Chinese Medicine; Babol University of Medical Sciences;
   Tehran University of Medical Sciences
RP Xu, YS (corresponding author), Shandong Univ Tradit Chinese Med, Affiliated Hosp 2, Dept Endocrinol, Jinan 250001, Peoples R China.
EM xys1965777@163.com
RI Ala, Moein/AAD-5514-2021; Eftekhar, Seyed Parsa/HNO-9443-2023
OI Xu, Yunsheng/0009-0001-3313-0720
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NR 184
TC 9
Z9 9
U1 6
U2 16
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0018-5043
EI 1439-4286
J9 HORM METAB RES
JI Horm. Metab. Res.
PD OCT
PY 2024
VL 56
IS 10
BP 683
EP 696
DI 10.1055/a-2266-1503
EA MAR 2024
PG 14
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA H5Z3O
UT WOS:001183533700002
PM 38471571
DA 2025-06-11
ER

PT J
AU Rostami, S
   Alvar, AA
   Ghaderi, P
   Dargahi, L
   Safari, MS
AF Rostami, Sareh
   Alvar, Amin Asgharzadeh
   Ghaderi, Parviz
   Dargahi, Leila
   Safari, Mir-Shahram
TI Investigating the Serotonergic Modulation of Orientation Tuning of
   Neurons in Primary Visual Cortex of Anesthetized Mice
SO BASIC AND CLINICAL NEUROSCIENCE
LA English
DT Article
DE Serotonergic modulation; Orientation tuning; Primary visual cortex; In
   vivo patchclamp recording; Dorsal raphe nucleus
ID CELLULAR SENESCENCE; ESTROGEN DEFICIENCY; BONE LOSS; METABOLIC SYNDROME;
   OXIDATIVE STRESS; ADIPOSE-TISSUE; CELLS; MECHANISMS; OSTEOPOROSIS;
   DYSFUNCTION
AB Introduction: Sensory processing is profoundly regulated by brain neuromodulatory systems. One of the main neuromodulators is serotonin which influences higher cognitive functions, such as different aspects of perceptual processing. Accordingly, malfunction in the serotonergic system may lead to visual illusion in psychiatric disorders, such as autism and schizophrenia. This study aims to investigate the serotonergic modulation of visual responses of neurons to stimulus orientation in the primary visual cortex.Methods: Eight-week-old naive mice were anesthetized and a craniotomy was done on the region of interest in the primary visual cortex. Spontaneous and visual-evoked activities of neurons were recorded before and during the electrical stimulation of the dorsal raphe nucleus using in vivo whole-cell patch-clamp recording. The square-wave grating of 12 orientations was presented. The data were analyzed and the Wilcoxon signed-rank test was used to compare the data of two conditions that belong to the same neurons, with or without electrical stimulation.Results: The serotonergic system changed the orientation tuning of nearly 60% of recorded neurons by decreasing the mean firing rate in two independent visual response components, namely gain and baseline response. It also increased the mean firing rate in a small number of neurons (about 20%). Additionally, it left the preferred orientation and sensitivity of neurons unchanged.Conclusion: Serotonergic modulation showed a bidirectional effect. It causes predominately divisive and subtractive decreases in the visual responses of the neurons in the primary visual cortex that can modify the balance between internal and external sensory signals and result in disorders.
C1 [Rostami, Sareh; Dargahi, Leila] Shahid Beheshti Univ Med Sci, Neurosci Res Ctr, Tehran, Iran.
   [Alvar, Amin Asgharzadeh] Shahid Beheshti Univ Med Sci, Student Res Comm, Fac Med, Dept Biomed Engn & Med Phys, Tehran, Iran.
   [Ghaderi, Parviz] Ecole Polytech Fed Lausanne EPFL, Brain Mind Inst, Fac Life Sci, Lab Sensory Proc, Lausanne, Switzerland.
   [Safari, Mir-Shahram] Shahid Beheshti Univ Med Sci, Fac Med, Neurosci Res Ctr, Dept Neurosci, Tehran, Iran.
C3 Shahid Beheshti University Medical Sciences; Shahid Beheshti University
   Medical Sciences; Swiss Federal Institutes of Technology Domain; Ecole
   Polytechnique Federale de Lausanne; Shahid Beheshti University Medical
   Sciences
RP Safari, MS (corresponding author), Shahid Beheshti Univ Med Sci, Fac Med, Neurosci Res Ctr, Dept Neurosci, Tehran, Iran.
EM safari@sbmu.ac.ir
RI Safari, Mir-Shahram/R-6557-2019; Dargahi, Leila/K-4693-2017
OI Dargahi, Leila/0000-0001-7777-5435
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NR 87
TC 0
Z9 0
U1 0
U2 1
PU IRAN UNIV MEDICAL SCIENCES
PI TEHRAN
PA COOPERATION IRAN NEUROSCIENCE SOC, NEGAH INST SCIENTIFIC COMMUNICATION,
   SHAHID HEMMAT HIGHWAY, TEHRAN, 1449614535, IRAN
SN 2008-126X
EI 2228-7442
J9 BASIC CLIN NEUROSCI
JI Basic Clin. Neurosci.
PD MAY-JUN
PY 2023
VL 14
IS 3
BP 419
EP 430
DI 10.32598/bcn.2021.3180.1
PG 12
WC Neurosciences
WE Emerging Sources Citation Index (ESCI)
SC Neurosciences & Neurology
GA U3FO3
UT WOS:001083692500011
PM 38077170
OA gold
DA 2025-06-11
ER

PT J
AU Fu, LW
   Wang, YQ
   Hu, YQ
AF Fu, Liwan
   Wang, Yuquan
   Hu, Yue-Qing
TI Association between homocysteine and nonalcoholic fatty liver disease:
   Mendelian randomisation study
SO EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
LA English
DT Article
DE homocysteine; liver enzymes; Mendelian randomisation; nonalcoholic liver
   disease
ID SERUM HOMOCYSTEINE; METABOLIC SYNDROME; ONE-CARBON; NAFLD; RISK;
   HYPERHOMOCYSTEINEMIA; PATHOGENESIS; SEVERITY; OBESITY; STRESS
AB Background Many observational studies explore the relationship between homocysteine (Hcy) and nonalcoholic fatty liver disease (NAFLD), whereas the causality of this association remains uncertain, especially in European populations. We performed a bidirectional Mendelian randomisation study to elucidate the causal association between Hcy and NAFLD. Furthermore, we explored the relationship of Hcy with liver enzymes, including alkaline phosphatase (ALP), alanine aminotransferase (ALT) and aspartate aminotransferase (AST). Methods Two-sample Mendelian randomisation study was conducted. Summary statistics for Hcy were obtained from a genome-wide association studies (GWAS) meta-analysis comprising 44,147 subjects. Summary-level data for NAFLD were acquired from a GWAS meta-analysis of 8434 cases and 770,180 noncases and another GWAS meta-analysis of 1483 cases and 17,781 noncases. Summary-level data for three liver enzymes were available from the UK Biobank. Results Genetic associations of Hcy concentrations with NAFLD and liver enzymes were observed. Genetically predicted higher Hcy concentrations were consistently associated with an increased NAFLD risk in two data sources. The combined odds ratio of NAFLD was 1.25 (95% confidence interval [CI], 1.05-1.45) per SD increase in Hcy concentrations. Genetically predicted higher Hcy concentrations showed significant association with ALP (Beta .69; 95% CI, 0.04-1.34), ALT (Beta 0.56; 95% CI, 0.15-0.97) and AST levels (Beta .57; 95% CI, 0.10-1.04). Genetic liability to NAFLD was not associated with Hcy concentrations. Conclusions This study has clinical implications as it indicates that increased Hcy concentrations increase the relevant liver enzymes and may play a role in NAFLD risk in European populations.
C1 [Fu, Liwan] Capital Med Univ, Beijing Childrens Hosp, Ctr Noncommunicable Dis Management, Natl Ctr Childrens Hlth, Beijing, Peoples R China.
   [Wang, Yuquan; Hu, Yue-Qing] Fudan Univ, Sch Life Sci, Human Phenome Inst, Inst Biostat,State Key Lab Genet Engn, Shanghai, Peoples R China.
   [Hu, Yue-Qing] Fudan Univ, Shanghai Ctr Math Sci, Shanghai, Peoples R China.
C3 Capital Medical University; Fudan University; Fudan University
RP Fu, LW (corresponding author), Beijing Childrens Hosp, Ctr Noncommunicable Dis Management, 56 Nanlishi Rd, Beijing 100045, Peoples R China.; Hu, YQ (corresponding author), Fudan Univ, Sch Life Sci, Inst Biostat, State Key Lab Genet Engn, 2005 Songhu Rd, Shanghai 200438, Peoples R China.
EM liwanfelix@foxmail.com; yuehu@fudan.edu.cn
RI HU, Yue-Qing/AAD-6447-2021; Fu, liwan/HHM-7192-2022
OI HU, Yue-Qing/0000-0002-5730-0317; Fu, Liwan/0000-0002-7851-6379
FU National Natural Science Foundation of China [82204063, 11971117,
   11571082]
FX National Natural Science Foundation of China, Grant/Award Number:
   82204063, 11971117 and 11571082
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NR 69
TC 11
Z9 11
U1 2
U2 24
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0014-2972
EI 1365-2362
J9 EUR J CLIN INVEST
JI Eur. J. Clin. Invest.
PD MAR
PY 2023
VL 53
IS 3
DI 10.1111/eci.13895
EA NOV 2022
PG 11
WC Medicine, General & Internal; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Research & Experimental Medicine
GA 8T8LY
UT WOS:000879811300001
PM 36305497
DA 2025-06-11
ER

PT J
AU Cao, Y
   Wang, WT
   Zhan, XR
   Zhang, YT
AF Cao, Yan
   Wang, Wantao
   Zhan, Xiaorong
   Zhang, Yitong
TI PRDX6: A protein bridging S-palmitoylation and diabetic neuropathy
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Article
DE diabetic neuropathy; DRG; S-palmitoylation; PRDX6; AE3; Cl- influx; pain
ID RAT SENSORY NEURONS; ANION-EXCHANGER 3; PEROXIREDOXIN 6; NADPH OXIDASE;
   CHANNELS; INJURY; CONTRIBUTES; INHIBITION; GENERATION; STRESS
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C1 [Cao, Yan] Sun Yat sen Univ Canc Ctr, Collaborat Innovat Ctr Canc Med, Dept Anesthesiol, State Key Lab Oncol South China, Guangzhou, Peoples R China.
   [Wang, Wantao] Sun Yat Sen Univ, Dept Spine Surg, Affiliated Hosp 1, Guangzhou, Peoples R China.
   [Zhan, Xiaorong] Southern Univ, Sci & Technol Hosp, Dept Endocrinol, Shenzhen, Peoples R China.
   [Zhang, Yitong] Beijing Inst Technol, Sch Life Sci, Beijing, Peoples R China.
C3 Sun Yat Sen University; State Key Lab Oncology South China; Sun Yat Sen
   University; Beijing Institute of Technology
RP Zhang, YT (corresponding author), Beijing Inst Technol, Sch Life Sci, Beijing, Peoples R China.
EM zhangyitong@bit.edu.cn
RI Zhang, Yitong/ABG-3653-2021; Wang, Wantao/LRV-1640-2024
OI Zhang, Yitong/0000-0002-1832-3508
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NR 43
TC 4
Z9 5
U1 0
U2 8
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD SEP 2
PY 2022
VL 13
AR 992875
DI 10.3389/fendo.2022.992875
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 4P2YP
UT WOS:000855264100001
PM 36120430
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Tardelli, LP
   Duchatsch, F
   Herrera, NA
   Ruiz, TFR
   Pagan, LU
   Vicentini, CA
   Okoshi, K
   Amaral, SL
AF Tardelli, Lidieli P. P.
   Duchatsch, Francine
   Herrera, Naiara A. A.
   Ruiz, Thalles Fernando R.
   Pagan, Luana U. U.
   Vicentini, Carlos A. A.
   Okoshi, Katashi
   Amaral, Sandra L. L.
TI Benefits of combined exercise training on arterial stiffness and blood
   pressure in spontaneously hypertensive rats treated or not with
   dexamethasone
SO FRONTIERS IN PHYSIOLOGY
LA English
DT Article
DE pulse wave velocity; aerobic training; resistance training; collagen
   deposition; hypertension; arteries
ID NITRIC-OXIDE; BAROREFLEX SENSITIVITY; RESISTANCE EXERCISE; METABOLIC
   SYNDROME; OXIDATIVE STRESS; ADULT SHEEP; HEART; IMPROVEMENT; ACTIVATION
AB Dexamethasone (DEX)-induced arterial stiffness is an important side-effect, associated with hypertension and future cardiovascular events, which can be counteracted by exercise training. The aim of this study was to evaluate the mechanisms induced by combined training to attenuate arterial stiffness and hypertension in spontaneously hypertensive rats treated or not with dexamethasone. Spontaneously hypertensive rats (SHR) underwent combined training for 74 days and were treated with dexamethasone (50 mu g/kg s. c.) or saline solution during the last 14 days. Wistar rats were used as controls. Echocardiographic parameters, blood pressure (BP) and pulse wave velocity (PWV), as well as histological analyses of the heart and aorta, carotid and femoral arteries were performed. At the beginning, SHR had higher BP and PWV compared with Wistar rats. After 60 days, while BP increased in sedentary SHR, combined exercise training decreased BP and PWV. After 74d, the higher BP and PWV of sedentary SHR was accompanied by autonomic imbalance to the heart, cardiac remodeling, and higher arterial collagen deposition. DEX treatment did not change these parameters. On the other hand, trained SHR had reduced BP and PWV, which was associated with better autonomic balance to the heart, reduced myocardial collagen deposition, as well as lower arterial collagen deposition. The results of this study suggest that combined training, through the reduction of aortic collagen deposition, is an important strategy to reduce arterial stiffness in spontaneously hypertensive rats, and these lower responses were maintained regardless of dexamethasone treatment.
C1 [Tardelli, Lidieli P. P.; Duchatsch, Francine; Herrera, Naiara A. A.; Amaral, Sandra L. L.] Univ Fed Sao Carlos, UNESP, Joint Grad Program Physiol Sci PIPGCF, Sao Carlos, SP, Brazil.
   [Tardelli, Lidieli P. P.; Duchatsch, Francine; Herrera, Naiara A. A.; Amaral, Sandra L. L.] Sao Paulo State Univ UNESP, Sch Sci, Dept Phys Educ, Bauru, SP, Brazil.
   [Ruiz, Thalles Fernando R.] Sao Paulo State Univ UNESP, Joint Grad Program Anim Biol, Sao Jose Do Rio Preto, SP, Brazil.
   [Pagan, Luana U. U.; Okoshi, Katashi] Sao Paulo State Univ UNESP, Botucatu Med Sch, Dept Internal Med, Botucatu, SP, Brazil.
   [Vicentini, Carlos A. A.] Sao Paulo State Univ UNESP, Sch Sci, Dept Biol Sci, Bauru, SP, Brazil.
C3 Universidade Estadual Paulista; Universidade Federal de Sao Carlos;
   Universidade Estadual Paulista; Universidade Estadual Paulista;
   Universidade Estadual Paulista; Universidade Estadual Paulista
RP Amaral, SL (corresponding author), Univ Fed Sao Carlos, UNESP, Joint Grad Program Physiol Sci PIPGCF, Sao Carlos, SP, Brazil.; Amaral, SL (corresponding author), Sao Paulo State Univ UNESP, Sch Sci, Dept Phys Educ, Bauru, SP, Brazil.
EM amaral.cardoso@unesp.br
RI Ruiz, Thalles/ABF-1105-2021; tardelli, lidieli/HKE-8701-2023; Okoshi,
   Katashi/A-3955-2011
OI Duchatsch Ribeiro de Souza, Francine/0000-0001-7061-4495; Ruiz, Thalles
   Fernando Rocha/0000-0003-0544-8325
FU Sao Paulo Research Foundation (FAPESP); Coordination for the Improvement
   of Higher Education Personnel (CAPES) [2017/00509-1, 2018/00567-4]; Sao
   Paulo Research Foundation (FAPESP/CAPES) [88882.426901/2019-01,
   2017/14405-3]; FAPESP [88882.426908/2019-01]; National Council for
   Scientific and Technological Development (CNPq) [2016/12532-5];
   Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior-Brasil
   (CAPES) [312160/2017-8];  [001]
FX This study was supported by Sao Paulo Research Foundation (FAPESP
   #2017/00509-1 grant to SLA and 2018/00567-4 to KO). LPT was recipient of
   scholarship from the Coordination for the Improvement of Higher
   Education Personnel (CAPES #88882.426901/2019-01). FD was recipient of
   scholarship from Sao Paulo Research Foundation (FAPESP/CAPES
   #2017/14405-3) and Coordination for the Improvement of Higher Education
   Personnel (CAPES #88882.426908/2019-01). NAH was recipient of
   scholarship from FAPESP (#2016/12532-5). SLA was a fellow of National
   Council for Scientific and Technological Development (CNPq), grant
   #312160/2017-8. This study was also financed in part by the Coordenacao
   de Aperfeicoamento de Pessoal de Nivel Superior-Brasil (CAPES)-Finance
   Code 001.
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NR 77
TC 4
Z9 4
U1 0
U2 7
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1664-042X
J9 FRONT PHYSIOL
JI Front. Physiol.
PD AUG 15
PY 2022
VL 13
AR 916179
DI 10.3389/fphys.2022.916179
PG 15
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA 4F3MU
UT WOS:000848419100001
PM 36045742
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Wang, RS
   Xue, FB
   Wang, LP
   Shi, GX
   Qian, GQ
   Yang, NB
   Chen, XQ
AF Wang, Rusha
   Xue, Feiben
   Wang, Liping
   Shi, Guangxia
   Qian, Guoqing
   Yang, Naibin
   Chen, Xueqin
TI Serum uric acid to creatinine ratio is associated with higher prevalence
   of NAFLD detected by FibroScan in the United States
SO JOURNAL OF CLINICAL LABORATORY ANALYSIS
LA English
DT Article
DE inflammation; NAFLD; NHANES; serum uric acid to creatinine ratio;
   steatosis
ID FATTY LIVER-DISEASE; METABOLIC SYNDROME; CHOLESTEROL RATIO; HEPATIC
   STEATOSIS; MANAGEMENT; GENERATION; PREDICTOR; STRESS
AB Background The association between the serum uric acid (sUA) to creatinine ratio (sUA/Cr) and non-alcoholic fatty liver disease (NAFLD) has not been sufficiently clarified. In this study, we investigated the relationship between sUA/Cr and NAFLD among participants in the United States. Methods We performed a cross-sectional study based on data from the National Health and Nutrition examination Survey (NHANES) 2017-2018. A measured controlled attenuation parameter (CAP) value of >= 274 dB/m detected by Fibroscan was used to identify hepatic steatosis. SUA/Cr was calculated as sUA divided by serum creatinine. Multivariate logistic regression analysis was used to estimate the association between sUA/Cr and NAFLD. The adjusted odds ratio (OR) of sUA/Cr for NAFLD was estimated, and subgroup analysis stratified by sex was also conducted. The nonlinear relationship between sUA/Cr and NAFLD was further described using smooth curve fittings and threshold-effect analysis. Results We found that sUA/Cr was positively correlated with NAFLD status after fully adjustment for confounding factors. In subgroup analysis stratified by sex, the positive interaction between sUA/Cr and NAFLD status only existed in women but not in men. Moreover, the nonlinear association between sUA/Cr and NAFLD status was an inverted U-shaped curve with an inflection point at 9.7 among men. Conclusions Our study identified that sUA/Cr was positively associated with the risk of NAFLD among individuals in the United States. Moreover, the correlation between sUA/Cr and NAFLD differed according to sex.
C1 [Wang, Rusha; Xue, Feiben; Wang, Liping; Shi, Guangxia; Qian, Guoqing; Yang, Naibin] Ningo Univ, Ningbo Hosp 1, Dept Infect Dis, Ningbo, Peoples R China.
   [Chen, Xueqin] Ningbo Univ, Ningbo Hosp 1, Dept Tradit Chinese Med, Liuting St 59, Ningbo 315010, Zhejiang, Peoples R China.
C3 Ningbo University
RP Chen, XQ (corresponding author), Ningbo Univ, Ningbo Hosp 1, Dept Tradit Chinese Med, Liuting St 59, Ningbo 315010, Zhejiang, Peoples R China.; Qian, GQ; Yang, NB (corresponding author), Ningbo Univ, Ningbo Hosp 1, Dept Infect Dis, 59 Liuting St, Ningbo 315010, Zhejiang, Peoples R China.
EM guoqing.qian@foxmail.com; mafld2021@163.com; cxq2316@163.com
RI Yang, Naibin/AAK-2341-2021; Qian, Guoqing/GRX-0691-2022; SHEN,
   Han-Ming/B-5942-2011
OI , Naibin/0000-0001-7439-723X
FU First Batch of Young Technical Backbone Talents Project of the Ningbo
   Municipal Health Commission; TianQing Liver Diseases Research Fund
   Subject of the Chinese Foundation for Hepatitis Prevention and Control
   [TQGB20180358]; Subject Funding for the Department of Infectious
   Diseases [2020001]; Natural Science Foundation of Zhejiang Province
   [Q17H010001]; Key Program of the Natural Science Foundation of Ningbo
   [202003 N4019]
FX This research was supported by the First Batch of Young Technical
   Backbone Talents Project of the Ningbo Municipal Health Commission (To
   Naibin Yang), TianQing Liver Diseases Research Fund Subject of the
   Chinese Foundation for Hepatitis Prevention and Control (No:
   TQGB20180358), Subject Funding for the Department of Infectious Diseases
   (No: 2020001), the Natural Science Foundation of Zhejiang Province (No:
   Q17H010001), and the Key Program of the Natural Science Foundation of
   Ningbo (No: 202003 N4019).
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NR 42
TC 6
Z9 6
U1 1
U2 15
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 0887-8013
EI 1098-2825
J9 J CLIN LAB ANAL
JI J. Clin. Lab. Anal.
PD AUG
PY 2022
VL 36
IS 8
AR e24590
DI 10.1002/jcla.24590
EA JUL 2022
PG 8
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA 3Y7AR
UT WOS:000825765700001
PM 35808891
OA Green Published
DA 2025-06-11
ER

PT J
AU Ahmadi, A
   Mortazavi, Z
   Mehri, S
   Hosseinzadeh, H
AF Ahmadi, Ali
   Mortazavi, Zoha
   Mehri, Soghra
   Hosseinzadeh, Hossein
TI Scutellaria baicalensis and its constituents baicalin and
   baicalein as antidotes or protective agents against chemical toxicities:
   a comprehensive review
SO NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
LA English
DT Review
DE Scutellaria baicalensis; Baicalin; Baicalein; Protective; Antidote;
   Chemical toxin
ID INDUCED OXIDATIVE STRESS; INDUCED DNA-DAMAGE; NF-KAPPA-B;
   DOXORUBICIN-INDUCED CARDIOTOXICITY; ROTENONE-INDUCED NEUROTOXICITY;
   MITOCHONDRIAL OXIDANT INJURY; INDUCED PULMONARY-FIBROSIS;
   PARKINSONS-DISEASE MODEL; JAPANESE HERBAL MEDICINE; INDUCED LIVER-INJURY
AB Scutellaria baicalensis (SB), also known as the Chinese skullcap, has a long history of being used in Chinese medicine to treat a variety of conditions ranging from microbial infections to metabolic syndrome and malignancies. Numerous studies have reported that treatment with total SB extract or two main flavonoids found in its root and leaves, baicalin (BA) and baicalein (BE), can prevent or alleviate the detrimental toxic effects of exposure to various chemical compounds. It has been shown that BA and BE are generally behind the protective effects of SB against toxicants. This paper aimed to review the protective and therapeutic effects of SB and its main components BA and BE against chemical compounds that can cause intoxication after acute or chronic exposure and seriously affect different vital organs including the brain, heart, liver, and kidneys. In this review paper, we had a look into a total of 221 in vitro and in vivo studies from 1995 to 2021 from the scientific databases PubMed, Scopus, and Web of Science which reported protective or therapeutic effects of BA, BE, or SB against drugs and chemicals that one might be exposed to on a professional or accidental basis and compounds that are primarily used to simulate disease models. In conclusion, the protective effects of SB and its flavonoids can be mainly attributed to increase in antioxidants enzymes, inhibition of lipid peroxidation, reduction of inflammatory cytokines, and suppression of apoptosis pathway.
C1 [Ahmadi, Ali; Mortazavi, Zoha] Mashhad Univ Med Sci, Sch Pharm, Mashhad, Razavi Khorasan, Iran.
   [Mehri, Soghra; Hosseinzadeh, Hossein] Mashhad Univ Med Sci, Inst Pharmaceut Technol, Pharmaceut Res Ctr, Mashhad, Razavi Khorasan, Iran.
   [Mehri, Soghra; Hosseinzadeh, Hossein] Mashhad Univ Med Sci, Sch Pharm, Dept Pharmacodynam & Toxicol, Mashhad, Razavi Khorasan, Iran.
C3 Mashhad University of Medical Sciences; Mashhad University of Medical
   Sciences; Mashhad University of Medical Sciences
RP Hosseinzadeh, H (corresponding author), Mashhad Univ Med Sci, Inst Pharmaceut Technol, Pharmaceut Res Ctr, Mashhad, Razavi Khorasan, Iran.; Hosseinzadeh, H (corresponding author), Mashhad Univ Med Sci, Sch Pharm, Dept Pharmacodynam & Toxicol, Mashhad, Razavi Khorasan, Iran.
EM hosseinzadehh@mums.ac.ir
RI Ahmadi, Ali/AAR-2967-2020; Hosseinzadeh, Hossein/F-3013-2010; mehri,
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NR 259
TC 17
Z9 18
U1 3
U2 64
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0028-1298
EI 1432-1912
J9 N-S ARCH PHARMACOL
JI Naunyn-Schmiedebergs Arch. Pharmacol.
PD NOV
PY 2022
VL 395
IS 11
BP 1297
EP 1329
DI 10.1007/s00210-022-02258-8
EA JUN 2022
PG 33
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 5I4FP
UT WOS:000807962300001
PM 35676380
DA 2025-06-11
ER

PT J
AU Louisa, M
   Patintingan, CGH
   Wardhani, BWK
AF Louisa, Melva
   Patintingan, Cyntia Gracesella Hutami
   Wardhani, Bantari W. K.
TI Moringa Oleifera Lam. in Cardiometabolic Disorders: A Systematic Review
   of Recent Studies and Possible Mechanism of Actions
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Review
DE metabolic syndrome; antioxidant; antiinflammation; flavonoids; lectin;
   Moringa oleifera (Moringaceae)
ID TARGET-ORGAN DAMAGE; LEAF EXTRACT; OXIDATIVE STRESS;
   CARDIOVASCULAR-DISEASE; ETHANOLIC EXTRACT; INDUCED NEPHROTOXICITY;
   ANTIOXIDANT ACTIVITIES; CARDIAC TOXICITY; AQUEOUS EXTRACT; GUT
   MICROBIOTA
AB Cardiometabolic disorders (CMD) have become a global emergency and increasing burden on health and economic problems. Due to the increasing need for new drugs for cardiometabolic diseases, many alternative medicines from plants have been considered and studied. Moringa oleifera Lam. (MO), one of the native plants from several Asian countries, has been used empirically by people for various kinds of illnesses. In the present systematic review, we aimed to investigate the recent studies of MO in CMD and its possible mechanism of action. We systematically searched from three databases and summarized the data. This review includes a total of 108 papers in nonclinical studies and clinical trials of MO in cardiometabolic-related disorders. Moringa oleifera, extracts or isolated compound, exerts its effect on CMD through its antioxidative, anti-inflammatory actions resulting in the modulation in glucose and lipid metabolism and the preservation of target organ damage. Several studies supported the beneficial effect of MO in regulating the gut microbiome, which generates the diversity of gut microbiota and reduces the number of harmful bacteria in the caecum. Molecular actions that have been studied include the suppression of NF-kB translocation, upregulation of the Nrf2/Keap1 pathway, stimulation of total antioxidant capacity by reducing PKC zeta activation, and inhibiting the Nox4 protein expression and several other proposed mechanisms. The present review found substantial evidence supporting the potential benefits of Moringa oleifera in cardiovascular or metabolic disorders.
C1 [Louisa, Melva] Univ Indonesia, Fac Med, Dept Pharmacol & Therapeut, Jakarta, Indonesia.
   [Patintingan, Cyntia Gracesella Hutami] Univ Indonesia, Fac Med, Master Program Biomed Sci, Jakarta, Indonesia.
   [Wardhani, Bantari W. K.] Indonesia Def Univ, Fac Mil Pharm, Dept Pharmacol, Java, Indonesia.
C3 University of Indonesia; University of Indonesia
RP Louisa, M (corresponding author), Univ Indonesia, Fac Med, Dept Pharmacol & Therapeut, Jakarta, Indonesia.
EM melva.louisa@gmail.com
RI Louisa, Melva/HNI-7441-2023
OI Patintingan, Cyntia Gracesella Hutami/0009-0006-0820-0279
FU Universitas Indonesia PUTI [PUTI NKB 1293/UN2.RST/PPM.00.03.01/2020]
FX This work was supported by Universitas Indonesia PUTI grants (PUTI NKB
   1293/UN2.RST/PPM.00.03.01/2020).
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NR 132
TC 14
Z9 14
U1 0
U2 9
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD MAR 30
PY 2022
VL 13
AR 792794
DI 10.3389/fphar.2022.792794
PG 13
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 0Y7ZN
UT WOS:000790605000001
PM 35431967
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Fatel, ECS
   Rosa, FT
   Alfieri, DF
   Flauzino, T
   Scavuzzi, BM
   Lozovoy, MAB
   Iriyoda, TMV
   Simao, ANC
   Dichi, I
AF Fatel, Elis C. S.
   Rosa, Flavia T.
   Alfieri, Daniela F.
   Flauzino, Tamires
   Scavuzzi, Bruna M.
   Lozovoy, Marcell A. B.
   Iriyoda, Tatiana M. V.
   Simao, Andrea N. C.
   Dichi, Isaias
TI Beneficial effects of fish oil and cranberry juice on disease activity
   and inflammatory biomarkers in people with rheumatoid arthritis
SO NUTRITION
LA English
DT Article
DE Rheumatoid arthritis; n-3 fish oil fatty acids; Cranberry; Polyphenols
ID POLYUNSATURATED FATTY-ACIDS; C-REACTIVE PROTEIN; PLASMA ANTIOXIDANT
   CAPACITY; CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; OXIDATIVE STRESS;
   SUPPLEMENTATION; ADIPONECTIN; MECHANISMS; RISK
AB Objectives: We sought to determine whether cranberry juice consumption would ameliorate laboratory and clinical measurements of disease activity in people with rheumatoid arthritis receiving fish oil supplementation.
   Methods: A prospective study was performed with 62 people with rheumatoid arthritis. We analyzed C-reactive protein modification of the Disease Activity Score-28 (DAS28-CRP) and inflammatory markers. The first group was assigned to eat their typical diet, a second group was asked to consume 3 g of fish oil omega-3 fatty acids daily, and a third group received both 3 g of fish oil n-3 fatty acids and 500 mL of reduced-calorie cranberry juice daily.
   Results: Compared with baseline values, the group receiving both fish oil and cranberry juice showed reductions in erythrocyte sedimentation rate (P = 0.033), C-reactive protein (P = 0.002), DAS28-CRP (P = 0.001), adiponectin (P = 0.021), and interleukin-6 levels (P = 0.045), whereas the fish oil group showed decreased DAS28-CRP (P = 0.0261) and adiponectin (P = 0.0239). Differences across treatments showed that the group receiving both fish oil and cranberry experienced reductions (P < 0.05) in erythrocyte sedimentation rate and C-reactive protein compared to the control group and the group treated with fish oil alone, and a reduction in DAS28-CRP was verified when the fish oil and cranberry group was compared to the control group.
   Conclusions: The ingestion of cranberry juice adds beneficial effects to fish oil supplementation, decreasing disease activity and inflammatory biomarkers in people with rheumatoid arthritis. (C) 2021 Elsevier Inc. All rights reserved.
C1 [Fatel, Elis C. S.; Alfieri, Daniela F.; Flauzino, Tamires; Scavuzzi, Bruna M.] Univ Estadual Londrina, Hlth Sci Grad Program, Londrina, Parana, Brazil.
   [Rosa, Flavia T.] Ctr Univ Filadelfia Londrina UNIFIL, Dept Nutr, Londrina, Parana, Brazil.
   [Lozovoy, Marcell A. B.; Simao, Andrea N. C.] Univ Estadual Londrina, Dept Pathol Clin Anal & Toxicol, Londrina, Parana, Brazil.
   [Iriyoda, Tatiana M. V.] Univ Hosp Univ Estadual Londrina, Londrina, Parana, Brazil.
   [Dichi, Isaias] Univ Estadual Londrina, Dept Internal Med, Londrina, Parana, Brazil.
C3 Universidade Estadual de Londrina; Universidade Estadual de Londrina;
   Universidade Estadual de Londrina
RP Dichi, I (corresponding author), Univ Estadual Londrina, Dept Internal Med, Londrina, Parana, Brazil.
EM dichi@sercomtel.com.br
RI Rosa, Flávia/D-5263-2013; Lozovoy, Marcell/AAM-4897-2021; Scavuzzi,
   Bruna/AAK-7916-2020; Alfieri, Daniela/LSI-6403-2024; Simão,
   Andrea/AAM-4892-2021
OI Alfieri, Daniela/0000-0002-0217-9329
FU National Council of Brazilian Research (CNPq)
FX This work was funded by the National Council of Brazilian Research
   (CNPq) . The Juxx Company supplied the cranberry juice, but had no role
   in the design, analysis, or writing of this article.
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NR 49
TC 15
Z9 15
U1 2
U2 7
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0899-9007
EI 1873-1244
J9 NUTRITION
JI Nutrition
PD JUN
PY 2021
VL 86
AR 111183
DI 10.1016/j.nut.2021.111183
EA FEB 2021
PG 6
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA SP0FT
UT WOS:000659348900021
PM 33636418
DA 2025-06-11
ER

PT J
AU Mandala, A
   Janssen, RC
   Palle, S
   Short, KR
   Friedman, JE
AF Mandala, Ashok
   Janssen, Rachel C.
   Palle, Sirish
   Short, Kevin R.
   Friedman, Jacob E.
TI Pediatric Non-Alcoholic Fatty Liver Disease: Nutritional Origins and
   Potential Molecular Mechanisms
SO NUTRIENTS
LA English
DT Review
DE pediatric NAFLD; clinical biomarkers; microRNAs; developmental
   programming; microbial dysbiosis; trained immunity
ID DE-NOVO LIPOGENESIS; INTESTINAL BACTERIAL OVERGROWTH; ETHENO-DNA
   ADDUCTS; INSULIN-RESISTANCE; MITOCHONDRIAL DYSFUNCTION; HEPATIC
   STEATOSIS; DIETARY FRUCTOSE; METABOLIC-SYNDROME; MATERNAL OBESITY;
   OXIDATIVE STRESS
AB Non-alcoholic fatty liver disease (NAFLD) is the number one chronic liver disease worldwide and is estimated to affect nearly 40% of obese youth and up to 10% of the general pediatric population without any obvious signs or symptoms. Although the early stages of NAFLD are reversible with diet and lifestyle modifications, detecting such stages is hindered by a lack of non-invasive methods of risk assessment and diagnosis. This absence of non-invasive means of diagnosis is directly related to the scarcity of long-term prospective studies of pediatric NAFLD in children and adolescents. In the majority of pediatric NAFLD cases, the mechanisms driving the origin and rapid progression of NAFLD remain unknown. The progression from NAFLD to non-alcoholic steatohepatitis (NASH) in youth is associated with unique histological features and possible immune processes and metabolic pathways that may reflect different mechanisms compared with adults. Recent data suggest that circulating microRNAs (miRNAs) are important new biomarkers underlying pathways of liver injury. Several factors may contribute to pediatric NAFLD development, including high-sugar diets, in utero exposures via epigenetic alterations, changes in the neonatal microbiome, and altered immune system development and mitochondrial function. This review focuses on the unique aspects of pediatric NAFLD and how nutritional exposures impact the immune system, mitochondria, and liver/gastrointestinal metabolic health. These factors highlight the need for answers to how NAFLD develops in children and for early stage-specific interventions.
C1 [Mandala, Ashok; Janssen, Rachel C.; Short, Kevin R.; Friedman, Jacob E.] Univ Oklahoma, Harold Hamm Diabet Ctr, Hlth Sci Ctr, Oklahoma City, OK 73104 USA.
   [Palle, Sirish] Univ Oklahoma, Hlth Sci Ctr, Dept Pediat, Sect Gastroenterol Hepatol & Nutr, Oklahoma City, OK 73104 USA.
   [Short, Kevin R.; Friedman, Jacob E.] Univ Oklahoma, Hlth Sci Ctr, Dept Pediat, Sect Diabet & Endocrinol, Oklahoma City, OK 73104 USA.
   [Short, Kevin R.; Friedman, Jacob E.] Univ Oklahoma, Hlth Sci Ctr, Dept Physiol, Oklahoma City, OK 73104 USA.
C3 University of Oklahoma System; University of Oklahoma Health Sciences
   Center; University of Oklahoma System; University of Oklahoma Health
   Sciences Center; University of Oklahoma System; University of Oklahoma
   Health Sciences Center; University of Oklahoma System; University of
   Oklahoma Health Sciences Center
RP Friedman, JE (corresponding author), Univ Oklahoma, Harold Hamm Diabet Ctr, Hlth Sci Ctr, Oklahoma City, OK 73104 USA.; Friedman, JE (corresponding author), Univ Oklahoma, Hlth Sci Ctr, Dept Pediat, Sect Diabet & Endocrinol, Oklahoma City, OK 73104 USA.; Friedman, JE (corresponding author), Univ Oklahoma, Hlth Sci Ctr, Dept Physiol, Oklahoma City, OK 73104 USA.
EM ashok-mandala@ouhsc.edu; rachel-janssen@ouhsc.edu;
   sirish-palle@ouhsc.edu; kevin-short@ouhsc.edu; jed-friedman@ouhsc.edu
RI Mandala, Ashok/J-4734-2019; Short, Kevin/AAC-2553-2020; Palle,
   Sirish/K-4572-2017
OI Friedman, Jacob E (Jed)/0000-0002-6426-1512; Mandala,
   Ashok/0000-0003-3473-2456
FU National Institutes of Health [R24-DK090964, R56-DK114711]
FX Support from the National Institutes of Health grants R24-DK090964 and
   R56-DK114711 to J.E.F.
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NR 201
TC 37
Z9 39
U1 0
U2 9
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD OCT
PY 2020
VL 12
IS 10
AR 3166
DI 10.3390/nu12103166
PG 23
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA OL6EM
UT WOS:000585430700001
PM 33081177
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Dangana, EO
   Omolekulo, TE
   Areola, ED
   Olaniyi, KS
   Soladoye, AO
   Olatunji, LA
AF Dangana, E. O.
   Omolekulo, T. E.
   Areola, E. D.
   Olaniyi, K. S.
   Soladoye, A. O.
   Olatunji, L. A.
TI Sodium acetate protects against nicotine-induced excess hepatic lipid in
   male rats by suppressing xanthine oxidase activity
SO CHEMICO-BIOLOGICAL INTERACTIONS
LA English
DT Article
DE Short-chain fatty acid; Xanthine oxidase; Fatty liver; Nicotine; Acetate
ID INSULIN-RESISTANCE; METABOLIC SYNDROME; OXIDATIVE STRESS;
   ATHEROSCLEROSIS RISK; STEATOSIS; LACTATE; GLUCOSE; OBESITY;
   PATHOGENESIS; ASSOCIATION
AB Fatty liver is the hepatic consequence of chronic insulin resistance (IR) and related syndromes. It is mostly accompanied by inflammatory and oxidative molecules. Increased activity of xanthine oxidase (XO) exerts both inflammatory and oxidative effects and has been implicated in metabolic derangements including non-alcoholic fatty liver disease. Short chain fatty acids (SCFAs) elicit beneficial metabolic alterations in IR and related syndromes. In the present study, we evaluated the preventive effects of a SCFA, acetate, on nicotine-induced dysmetabolism and fatty liver. Twenty-four male Wistar rats (n = 6/group): vehicle-treatment (p.o.), nicotinetreated (1.0 mg/kg; p.o.), sodium acetate-treated (200 mg/kg; p.o.) and nicotine + sodium acetate-treated groups. The treatments lasted for 8 weeks. IR was estimated by oral glucose tolerance test and homeostatic model assessment of IR. Plasma and hepatic free fatty acid, triglyceride (TG), glutathione peroxidase, adenosine deaminase (ADA), XO and uric acid (UA) were measured. Nicotine exposure resulted in reduced body weight, liver weight, visceral adiposity, glycogen content and glycogen synthase activity. Conversely, exposure to nicotine increased fasting plasma glucose, lactate, IR, plasma and hepatic TG, free fatty acid, TG/HDL-cholesterol ratio, lipid peroxidation, liver function enzymes, plasma and hepatic UA, XO and ADA activities. However, plasma and hepatic glucose-6-phosphate dehydrogenase-dependent antioxidant defense was not affected by nicotine. Concomitant treatment with acetate ameliorated nicotine-induced effects. Taken together, these results indicate that nicotine exposure leads to excess deposition of lipid in the liver by enhancing XO activity. The results also imply that acetate confers hepatoprotection and is accompanied by decreased XO activity.
C1 [Dangana, E. O.; Omolekulo, T. E.; Areola, E. D.; Olaniyi, K. S.; Olatunji, L. A.] Univ Ilorin, HOPE Cardiometab Res Team, Ilorin, Nigeria.
   [Dangana, E. O.; Omolekulo, T. E.; Areola, E. D.; Olaniyi, K. S.; Olatunji, L. A.] Univ Ilorin, Coll Hlth Sci, Ilorin, Nigeria.
   [Dangana, E. O.; Omolekulo, T. E.; Areola, E. D.; Olaniyi, K. S.; Soladoye, A. O.; Olatunji, L. A.] Univ Ilorin, Coll Hlth Sci, Dept Physiol, PMB 1515, Ilorin 240003, Nigeria.
C3 University of Ilorin; University of Ilorin; University of Ilorin
RP Olatunji, LA (corresponding author), Univ Ilorin, HOPE Cardiometab Res Team, Ilorin, Nigeria.; Olatunji, LA (corresponding author), Univ Ilorin, Coll Hlth Sci, Ilorin, Nigeria.; Olatunji, LA (corresponding author), Univ Ilorin, Coll Hlth Sci, Dept Physiol, PMB 1515, Ilorin 240003, Nigeria.
EM tunjilaw@unilorin.edu.ng
RI Areola, Emmanuel/JBS-2835-2023; Olaniyi, Kehinde/GPK-5850-2022
OI Olatunji, Lawrence Aderemi/0000-0002-1036-0662; Olaniyi,
   Kehinde/0000-0002-8229-9688
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NR 47
TC 41
Z9 43
U1 1
U2 17
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0009-2797
EI 1872-7786
J9 CHEM-BIOL INTERACT
JI Chem.-Biol. Interact.
PD JAN 25
PY 2020
VL 316
AR 108929
DI 10.1016/j.cbi.2019.108929
PG 10
WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology
GA KN4NM
UT WOS:000514815400018
PM 31857090
DA 2025-06-11
ER

PT J
AU Bosebabu, B
   Cheruku, SP
   Chamallamudi, MR
   Nampoothiri, M
   Shenoy, RR
   Nandakumar, K
   Parihar, VK
   Kumar, N
AF Bosebabu, Bellamkonda
   Cheruku, Sri Pragnya
   Chamallamudi, Mallikarjuna Rao
   Nampoothiri, Madhavan
   Shenoy, Rekha R.
   Nandakumar, Krishnadas
   Parihar, Vipan K.
   Kumar, Nitesh
TI An Appraisal of Current Pharmacological Perspectives of Sesamol: A
   Review
SO MINI-REVIEWS IN MEDICINAL CHEMISTRY
LA English
DT Review
DE Sesamol; pleiotropic sesame seed; antioxidant; anti-inflammatory;
   pharmacological activities; anti-microbial; cancer cells; in vitro; in
   vivo
ID SOLID LIPID NANOPARTICLES; CHLORIDE-INDUCED DEMENTIA; INDUCED OXIDATIVE
   STRESS; COLON-CANCER CELLS; INDUCED DNA-DAMAGE; BIOCHEMICAL-ALTERATIONS;
   ANTIOXIDANT ACTIVITIES; MYOCARDIAL-INFARCTION; INFLAMMATORY RESPONSE;
   COGNITIVE DEFICITS
AB Sesame (Sesamum indicum L.) seeds have been authenticated for its medicinal value in both Chinese and Indian systems of medicine. Its numerous potential nutritional benefits are attributed to its main bioactive constituents, sesamol. As a result of those studies, several molecular mechanisms are emerging describing the pleiotropic biological effects of sesamol. This review summarized the most interesting in vitro and in vivo studies on the biological effects of sesamol. The present work summarises data available from Pubmed and Scopus database. Several molecular mechanisms have been elucidated describing the pleiotropic biological effects of sesamol. Its major therapeutic effects have been elicited in managing oxidative and inflammatory conditions, metabolic syndrome and mood disorders. Further, compelling evidence reflected the ability of sesamol in inhibiting proliferation of the inflammatory cell, prevention of invasion and angiogenesis via affecting multiple molecular targets and downstream mechanisms. Sesamol is a safe, non-toxic chemical that mediates anti-inflammatory effects by down-regulating the transcription of inflammatory markers such as cytokines, redox status, protein kinases, and enzymes that promote inflammation. In addition, sesamol also induces apoptosis in cancer cells via mitochondrial and receptor-mediated pathways, as well as activation of caspase cascades. In the present review, several pharmacological effects of sesamol are summarised namely, antioxidant, anti-cancer, neuroprotective, cardioprotective, anti-inflammatory, hypolipidemic, radioprotective, anti-aging, anti-ulcer, anti-dementia, anti-depressant, antiplatelet, anticonvulsant, anti-anxiolytic, wound healing, cosmetic (skin whitening), anti-microbial, matrix metalloproteinase (MMPs) inhibition, hepatoprotective activity and other biological effects. Here we have summarized the proposed mechanism behind these pharmacological effects.
C1 [Bosebabu, Bellamkonda; Cheruku, Sri Pragnya; Chamallamudi, Mallikarjuna Rao; Nampoothiri, Madhavan; Shenoy, Rekha R.; Nandakumar, Krishnadas; Kumar, Nitesh] Manipal Acad Higher Educ, Manipal Coll Pharmaceut Sci, Dept Pharmacol, Manipal 576104, Karnataka, India.
   [Parihar, Vipan K.] Univ Calif Irvine, Dept Radiat Oncol, Irvine, CA 92697 USA.
C3 Manipal Academy of Higher Education (MAHE); University of California
   System; University of California Irvine
RP Kumar, N (corresponding author), Manipal Acad Higher Educ, Manipal Coll Pharmaceut Sci, Dept Pharmacol, Manipal 576104, Karnataka, India.
EM niteshkumar43@gmail.com
RI Kumar, Nitesh/JGE-0321-2023; Nandakumar, Krishnadas/H-3420-2019;
   Parihar, Vipan Kumar/Z-1195-2018; Kumar, Nitesh/V-4466-2019
OI Nampoothiri g, Madhavan/0000-0003-2218-2004; shenoy,
   rekha/0000-0001-7684-1242; BABU, BOSE/0000-0001-5185-1903; Nandakumar,
   Krishnadas/0000-0001-6653-4660; Parihar, Vipan
   Kumar/0000-0003-4878-7386; Kumar, Nitesh/0000-0002-4929-3954;
   Chamallamudi, Mallikarjuna Rao/0000-0003-3744-8135
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NR 99
TC 40
Z9 42
U1 4
U2 49
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1389-5575
EI 1875-5607
J9 MINI-REV MED CHEM
JI Mini-Rev. Med. Chem.
PY 2020
VL 20
IS 11
BP 988
EP 1000
DI 10.2174/1389557520666200313120419
PG 13
WC Chemistry, Medicinal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA MO7BB
UT WOS:000551675400004
PM 32167426
DA 2025-06-11
ER

PT J
AU Roszkiewicz, M
   Dopytalska, K
   Szymanska, E
   Jakimiuk, A
   Walecka, I
AF Roszkiewicz, Marek
   Dopytalska, Klaudia
   Szymanska, Elzbieta
   Jakimiuk, Artur
   Walecka, Irena
TI Environmental risk factors and epigenetic alternations in psoriasis
SO ANNALS OF AGRICULTURAL AND ENVIRONMENTAL MEDICINE
LA English
DT Review
DE psoriasis; habits; environmental factors; epigenetic alternations
ID BODY-MASS INDEX; SYSTEMIC INFLAMMATION; SUSCEPTIBILITY LOCI; DNA
   METHYLATION; OBESE-PATIENTS; SMOKING; ASSOCIATION; ARTHRITIS; DIET; SKIN
AB Introduction and objective. Psoriasis isa quite common, chronic and immune-mediated skin disorder. The prevalence of psoriasis differs in various countries, but it is said to affect 2% of the world's population in general. Psoriasis has many different clinical features but all lesions have the same characteristic: erythema, thickening and scale, although other clinical features are also connected, such as psoriatic arthritis, obesity and metabolic syndrome. All of these may lead to conditions impairing the quality of life. This review is an attempt to summarize recent data regarding environmental factors, together with epigenetic markers and processes playing an important role in psoriasis.
   State of knowledge. Many different environmental factors play a role in genetically predisposed patients. This is causes epigenetic alternations which may be a linking part in the whole process. Many studies have indicated a connection between psoriasis and various genes and antigens. The presence of HLA-Cw6 is common as well a strong link between its presence and the onset of psoriasis being observed. The main alternations are DNA methylation, histone's modifications and the role of microRNA. Excessive reaction is usually not present without a triggering factor. Environmental factors are mostly rated, such as drugs, life style and habits (smoking, alcohol), diet, physical trauma (skin injury provoking Koebner phenomenon), stress, microorganism and infections.
   Conclusions. The correlation between pathogenesis of psoriasis and environmental risk factors, together with epigenetic alternations still require more investigation. Education about diet habits, nutrition, weight loss and healthy lifestyle seems to be important during the treatment of psoriasis.
C1 [Roszkiewicz, Marek; Dopytalska, Klaudia; Szymanska, Elzbieta; Walecka, Irena] Ctr Postgrad Med Educ, Dermatol Dept, Warsaw, Poland.
   [Jakimiuk, Artur] Ctr Reprod Hlth, Inst Mother & Child, Warsaw, Poland.
   [Jakimiuk, Artur] Dept Obstet & Gynecol CSKMSWiA, Warsaw, Poland.
C3 Centre of Postgraduate Medical Education - Poland
RP Roszkiewicz, M (corresponding author), Ctr Postgrad Med Educ, Dermatol Dept, Warsaw, Poland.
EM marek.roszkiewicz@cskmswia.pl
RI Jakimiuk, Artur/MGA-6902-2025
OI Roszkiewicz, Marek/0000-0002-2764-344X; Walecka,
   Irena/0000-0002-3502-3339; Dopytalska, Klaudia/0000-0002-3692-2635;
   Jakimiuk, Artur/0000-0002-7373-7690
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NR 120
TC 56
Z9 59
U1 2
U2 28
PU Inst Rural Health Lublin, Poland
PI LUBLIN
PA JACZEWSKIEGO 2, PO BOX 185, 20-950 LUBLIN, POLAND
SN 1232-1966
EI 1898-2263
J9 ANN AGR ENV MED
JI Ann. Agr. Env. Med.
PY 2020
VL 27
IS 3
BP 335
EP 342
DI 10.26444/aaem/112107
PG 8
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA NO4MB
UT WOS:000569458100003
PM 32955211
OA gold
DA 2025-06-11
ER

PT J
AU Zhou, JY
   Huang, XL
   Jiang, XH
AF Zhou, Jiayan
   Huang, Xiaolin
   Jiang, Xiaohong
TI Effects of Obstructive Sleep Apnea-Hypopnea Syndrome on Serum
   Carcinoembryonic Antigen Levels in Patients with Type 2 Diabetes
   Mellitus
SO MEDICAL SCIENCE MONITOR
LA English
DT Article
DE Carcinoembryonic Antigen; Diabetes Mellitus; Sleep Apnea, Obstructive
ID OXIDATIVE STRESS; METABOLIC SYNDROME; PREVALENCE; EXPRESSION; HYPOXIA;
   OBESITY; POPULATION; RISK; MEN; CEA
AB Background: Type 2 diabetes mellitus (T2DM) is related to the serum carcinoembryonic antigen (CEA) level, which is used as a marker of colorectal cancer. Obstructive sleep apnea-hypopnea syndrome (OSAS) has been recently reported to have cancer-promoting effects. The aim of our study was to observe the effect of OSAS on serum levels of CEA in patients with T2DM.
   Material/Methods: We enrolled 401 T2DM patients in this study. There were 244 patients with OSAS and 157 patients without OSAS.
   Results: The CEA level in T2DM patients with OSAS was higher than that in those without OSAS (p<0.05). The participants with AHI scores >= 30 had higher CEA levels than those with 5 <= AHI scores <30 (p<0.05). The AHI score and ODI score were independently associated with increased risk of high CEA level in T2DM patients (odds ratio [OR]=1.052, 95% confidence interval [CI]: 1.011 similar to 1.095) and (OR=1.214, 95% CI: 1.070 similar to 1.377). Moreover, among male T2DM patients, the AHI score and ODI score had a linear correlation with the CEA level; this association was also observed in T2DM patients who smoked, had an HbA1c level >= 7%, or had a BMI >= 28 kg/m(2) (all p<0.05).
   Conclusions: The AHI score and ODI score were positively associated with the CEA level in T2DM patients. The relationship was stronger in male T2DM patients and in those who smoked, were obese, or had poor glycemic control. The mechanism may be related to metabolic disorders, and the potential increased risk of colorectal cancer should be investigated in a prospective study.
C1 [Zhou, Jiayan; Huang, Xiaolin; Jiang, Xiaohong] First Peoples Hosp Changzhou, Dept Endocrinol, Changzhou, Jiangsu, Peoples R China.
RP Jiang, XH (corresponding author), First Peoples Hosp Changzhou, Dept Endocrinol, Changzhou, Jiangsu, Peoples R China.
EM 1617141689@qq.com
FU Government of Changzhou
FX Financial support in the form of grants was from the Government of
   Changzhou
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NR 28
TC 4
Z9 4
U1 0
U2 3
PU INT SCIENTIFIC INFORMATION, INC
PI MELVILLE
PA 150 BROADHOLLOW RD, STE 114, MELVILLE, NY 11747 USA
SN 1643-3750
J9 MED SCI MONITOR
JI Med. Sci. Monitor
PD MAY 14
PY 2019
VL 25
BP 3558
EP 3565
DI 10.12659/MSM.913713
PG 8
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA HY3OH
UT WOS:000468035500001
PM 31086125
OA Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Pokimica, B
   García-Conesa, MT
   Zec, M
   Debeljak-Martacic, J
   Rankovic, S
   Vidovic, N
   Petrovic-Oggiano, G
   Konic-Ristic, A
   Glibetic, M
AF Pokimica, Biljana
   Garcia-Conesa, Maria-Teresa
   Zec, Manja
   Debeljak-Martacic, Jasmina
   Rankovic, Slavica
   Vidovic, Nevena
   Petrovic-Oggiano, Gordana
   Konic-Ristic, Aleksandra
   Glibetic, Maria
TI Chokeberry Juice Containing Polyphenols Does Not Affect Cholesterol or
   Blood Pressure but Modifies the Composition of Plasma Phospholipids
   Fatty Acids in Individuals at Cardiovascular Risk
SO NUTRIENTS
LA English
DT Article
DE Aronia; anthocyanins; polyphenols; obesity; hyperlipidemia; blood
   pressure; SFA; n-6 PUFA; palmitic acid; cardiovascular risk factors
ID LOW-DENSITY-LIPOPROTEIN; CORONARY-HEART-DISEASE; 2016 EUROPEAN
   GUIDELINES; ARONIA-MELANOCARPA; LIPID-PEROXIDATION; METABOLIC SYNDROME;
   OXIDATIVE STRESS; CONSUMPTION; PREVENTION; BIOMARKERS
AB Chokeberry polyphenols have been suggested to reduce cholesterol and blood pressure and thus protect against cardiovascular diseases (CVD), but the evidence in humans is limited and inconsistent. This randomized double-blinded three-parallel groups trial investigated the changes in various anthropometric and clinical biomarkers, and in plasma phospholipids fatty acids (PPFA) in volunteers at cardiovascular risk after a four-week intervention with 100 mL/day of (1) chokeberry juice with a high-dose of polyphenols (1177.11 mg gallic acid equivalents, GAE); (2) chokeberry juice with a low-dose of polyphenols (294.28 mg GAE) and; (3) a nutritionally matched polyphenol-free placebo drink. Our results indicate that the intake of chokeberry juice containing either the low or the high dose of polyphenols cannot be linked with a reduction in total- and low-density lipoprotein (LDL)cholesterol or in systolic (SBP) and diastolic (DBP) blood pressure in comparison with the consumption of the placebo drink. However, we found evidence of moderate changes in the PPFA, i.e., increased saturated fatty acids (SFA), mostly palmitic acid, and reduced n-6 polyunsaturated fatty acids (PUFA), principally linoleic acid (LA) with the intake of chokeberry against the placebo. These effects may be associated with the polyphenols but we could not differentiate a clear dose-response effect. Further research is still needed to elucidate the contribution of the polyphenolic fraction to the potential cardiovascular effects of the chokeberry and to build up the evidence of its potential benefit via the modulation of PPFA composition.
C1 [Pokimica, Biljana; Zec, Manja; Debeljak-Martacic, Jasmina; Rankovic, Slavica; Vidovic, Nevena; Petrovic-Oggiano, Gordana; Konic-Ristic, Aleksandra; Glibetic, Maria] Univ Belgrade, Ctr Res Excellence Nutr & Metab, Inst Med Res, Belgrade 11000, Serbia.
   [Garcia-Conesa, Maria-Teresa] CSIC, CEBAS, Res Grp Qual Safety & Bioact Plant Foods, Campus Espinardo,POB 164, Murcia 30100, Spain.
C3 University of Belgrade; Consejo Superior de Investigaciones Cientificas
   (CSIC); CSIC - Centro de Edafologia y Biologia Aplicada del Segura
   (CEBAS)
RP García-Conesa, MT (corresponding author), CSIC, CEBAS, Res Grp Qual Safety & Bioact Plant Foods, Campus Espinardo,POB 164, Murcia 30100, Spain.
EM biljana.pokimica@hotmail.com; mtconesa@cebas.csic.es;
   manjazecimr@gmail.com; minaizdravko@yahoo.com;
   slavica.rankovic.imr@gmail.com; nevenakardum@gmail.com;
   g5petrovic@gmail.com; sandrakonic@gmail.com; mglibetic@gmail.com
RI García-Conesa, María-Teresa/N-4032-2014; Konic Ristic,
   Aleksandra/KDM-9154-2024; Vidovic, Nevena/AFT-1529-2022; Zec,
   Manja/T-5942-2019; Konic Ristic, Aleksandra/D-7634-2014
OI Zec, Manja/0000-0001-5283-9295; Konic Ristic,
   Aleksandra/0000-0002-1218-1190; Debeljak Martacic,
   Jasmina/0000-0002-9605-3793
FU Ministry of Education, Science and Technological Development of the
   Republic of Serbia [III 41030]; EU FP7 project BACCHUS [312090]; COST
   Action "Interindividual variation in response to consumption of plant
   food bioactives and determinants involved" by COST (European Cooperation
   in Science and Technology [FA1403-POSITIVe]
FX This work was supported by the Ministry of Education, Science and
   Technological Development of the Republic of Serbia (Grant III 41030)
   and by the EU FP7 project BACCHUS (Grant agreement no 312090). The
   author(s) would like to acknowledge networking support by the COST
   Action FA1403-POSITIVe "Interindividual variation in response to
   consumption of plant food bioactives and determinants involved"
   supported by COST (European Cooperation in Science and Technology,
   http://www.cost.eu/).
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NR 71
TC 36
Z9 37
U1 0
U2 16
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD APR
PY 2019
VL 11
IS 4
AR 850
DI 10.3390/nu11040850
PG 20
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA HX9SX
UT WOS:000467749800143
PM 30991718
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Bouyanfif, A
   Jayarathne, S
   Koboziev, I
   Moustaid-Moussa, N
AF Bouyanfif, Amal
   Jayarathne, Shasika
   Koboziev, Iurii
   Moustaid-Moussa, Naima
TI The Nematode Caenorhabditis elegans as a Model Organism to Study
   Metabolic Effects of ω-3 Polyunsaturated Fatty Acids in Obesity
SO ADVANCES IN NUTRITION
LA English
DT Review
DE C. elegans; obesity; omega-3 fatty acids; metabolism; inflammation;
   microRNA; gene regulation
ID C. ELEGANS; INSULIN-RESISTANCE; CARDIOVASCULAR-DISEASE; LIFE-SPAN;
   INFLAMMATION; MICRORNAS; EXPRESSION; OMEGA-3-FATTY-ACIDS; PROTECTINS;
   RESOLVINS
AB Obesity is a complex disease that is influenced by several factors, such as diet, physical activity, developmental stage, age, genes, and their interactions with the environment. Obesity develops as a result of expansion of fatmass when the intake of energy, stored as triglycerides, exceeds its expenditure. Approximately 40% of the US population suffers from obesity, which represents a worldwide public health problem associated with chronic low-grade adipose tissue and systemic inflammation (sterile inflammation), in part due to adipose tissue expansion. In patients with obesity, energy homeostasis is further impaired by inflammation, oxidative stress, dyslipidemia, and metabolic syndrome. These pathologic conditions increase the risk of developing other chronic diseases including diabetes, hypertension, coronary artery disease, and certain forms of cancer. It is well documented that several bioactive compounds such as omega-3 polyunsaturated fatty acids (omega-3 PUFAs) are able to reduce adipose and systemic inflammation and blood triglycerides and, in some cases, improve glucose intolerance and insulin resistance in vertebrate animal models of obesity. A promising model organism that is gaining tremendous interest for studies of lipid and energy metabolism is the nematode Caenorhabditis elegans. This roundworm stores fats as droplets within its hypodermal and intestinal cells. The nematode's transparent skin enables fat droplet visualization and quantification with the use of dyes that have affinity to lipids. This article provides a review of major research over the past several years on the use of C. elegans to study the effects of omega-3 PUFAs on lipid metabolism and energy homeostasis relative to metabolic diseases.
C1 [Bouyanfif, Amal; Moustaid-Moussa, Naima] Texas Tech Univ, Dept Plant & Soil Sci, Lubbock, TX 79409 USA.
   [Bouyanfif, Amal; Jayarathne, Shasika; Koboziev, Iurii; Moustaid-Moussa, Naima] Texas Tech Univ, Dept Nutr Sci, Lubbock, TX 79409 USA.
   [Jayarathne, Shasika; Koboziev, Iurii; Moustaid-Moussa, Naima] Texas Tech Univ, Obes Res Cluster, Lubbock, TX 79409 USA.
C3 Texas Tech University System; Texas Tech University; Texas Tech
   University System; Texas Tech University; Texas Tech University System;
   Texas Tech University
RP Moustaid-Moussa, N (corresponding author), Texas Tech Univ, Dept Plant & Soil Sci, Lubbock, TX 79409 USA.; Moustaid-Moussa, N (corresponding author), Texas Tech Univ, Dept Nutr Sci, Lubbock, TX 79409 USA.; Moustaid-Moussa, N (corresponding author), Texas Tech Univ, Obes Res Cluster, Lubbock, TX 79409 USA.
EM naima.moustaid-moussa@ttu.edu
RI Moustaid-Moussa, Naima/B-9067-2014; Bouyanfif, Amal/T-1514-2017
OI Bouyanfif, Amal/0000-0002-4361-0912
FU USDA Agriculture and Food Research Initiative (AFRI) National Institute
   of Food and Agriculture (NIFA) exploratory award [2014-07216]; Texas
   Tech University Obesity Research Cluster
FX Supported in part by the USDA Agriculture and Food Research Initiative
   (AFRI) National Institute of Food and Agriculture (NIFA) exploratory
   award 2014-07216 (to NM-M) and the Texas Tech University Obesity
   Research Cluster (to NM-M).
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NR 112
TC 37
Z9 39
U1 7
U2 42
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 2161-8313
EI 2156-5376
J9 ADV NUTR
JI Adv. Nutr.
PD JAN
PY 2019
VL 10
IS 1
BP 165
EP 178
DI 10.1093/advances/nmy059
PG 14
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA HK9KP
UT WOS:000458310600016
PM 30689684
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Pang, NQ
   Kow, WCA
   Law, JH
   Pan, LTT
   Lim, BLK
   Wong, CCR
   Chang, KYS
   Ganpathi, IS
   Madhavan, K
AF Pang, N. Q.
   Kow, W. C. A.
   Law, J. H.
   Pan, L. T. T.
   Lim, B. L. K.
   Wong, C. C. R.
   Chang, K. Y. S.
   Ganpathi, I. S.
   Madhavan, K.
TI Role of Coronary Angiography in Pre-Liver Transplantation Cardiac
   Evaluation: Experience From an Asian Transplant Institution
SO TRANSPLANTATION PROCEEDINGS
LA English
DT Article
ID DOBUTAMINE STRESS ECHOCARDIOGRAPHY; AMERICAN-HEART-ASSOCIATION;
   ARTERY-DISEASE; CARDIOVASCULAR-DISEASE; PRACTICE GUIDELINES;
   PREDICTIVE-VALUE; RISK-ASSESSMENT; CANDIDATES; PREVALENCE; MANAGEMENT
AB Background. Liver transplant (LT) patients with significant coronary artery disease (CAD) have poorer outcomes. Pre-LT coronary angiography (CA) is associated with significant complications in cirrhotic patients.
   Methods. This study aimed to identify predictors of abnormal CA in pre-LT cardiac assessment and to develop a predictive model to reduce unnecessary CA. From January 2006 to June 2013, 122 patients underwent CA based on the current institutional protocol.
   Results. Forty-one (33.6%) patients had abnormal CA. Univariate analysis showed age >= 65 years (P =.001), cryptogenic cirrhosis (P =.046), cardiac comorbidities (P =.027), ischemic heart disease (IHD; P =.002), left ventricular hypertrophy (LVH; P =.004), hypertension (P =.002), diabetes mellitus (P =.017), dyslipidemia (P <.001), metabolic syndrome (P =.003), >= 2 CAD risk factors (P =.001), and high Framingham risk score (hard CAD risk, P =.018; cardiovascular disease: lipids, P =.002; body mass index, P <.001) to be significant predictors of abnormal CA. A predictive model was developed with the use of multivariable logistic regression and included diabetes, dyslipidemia, IHD, age > 65 years, and LVH, achieving a specificity of 55.1% and sensitivity of 90.0%. This would reduce unnecessary CA by up to one-half in our study population (from 81 to 35) while maintaining a false negative rate of only 8.5%.
   Conclusions. Diabetes, dyslipidemia, IHD, age >= 65 years, and LVH appear to be predictors of abnormal CA in pre-LT patients. Our predictive model may help to better select patients for CA, although further validation is required.
C1 [Pang, N. Q.; Kow, W. C. A.; Chang, K. Y. S.; Ganpathi, I. S.; Madhavan, K.] Natl Univ Hlth Syst, Dept Surg, Singapore, Singapore.
   [Law, J. H.] Natl Univ Singapore, Yong Loo Lin Sch Med, Singapore, Singapore.
   [Pan, L. T. T.] Natl Univ Hlth Syst, Dept Anaesthesiol, Singapore, Singapore.
   [Lim, B. L. K.] Natl Univ Hlth Syst, Dept Gastroenterol & Hepatol, Singapore, Singapore.
   [Wong, C. C. R.] Natl Univ Hlth Syst, Dept Cardiol, Singapore, Singapore.
C3 National University of Singapore; National University of Singapore;
   National University of Singapore; National University of Singapore;
   National University of Singapore
RP Kow, WCA (corresponding author), Natl Univ Singapore Hosp, Div Hepatobiliary & Pancreat Surg & Liver Transpl, Univ Surg Cluster, 1E,Kent Ridge Rd,NUNS Tower Block,Level 8, Singapore 119228, Singapore.
EM alfred_kow@nuhs.edu.sg
RI Madhavan, Krishnakumar/B-4633-2011; Iyer, Shridhar/B-5194-2011; Kow,
   Alfred/K-1691-2017
OI Madhavan, Krishnakumar/0000-0002-6267-9368; Law, Jia
   Hao/0000-0002-2059-3304
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NR 39
TC 1
Z9 1
U1 0
U2 4
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0041-1345
EI 1873-2623
J9 TRANSPL P
JI Transplant. Proc.
PD OCT
PY 2017
VL 49
IS 8
BP 1797
EP 1805
DI 10.1016/j.transproceed.2017.04.021
PG 9
WC Immunology; Surgery; Transplantation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Surgery; Transplantation
GA FI4BI
UT WOS:000411913900020
PM 28923628
DA 2025-06-11
ER

PT J
AU Morrell, A
   Tallino, S
   Yu, L
   Burkhead, JL
AF Morrell, Austin
   Tallino, Savannah
   Yu, Lei
   Burkhead, Jason L.
TI The Role of Insufficient Copper in Lipid Synthesis and Fatty-Liver
   Disease
SO IUBMB LIFE
LA English
DT Review
DE copper deficiency; non-alcoholic fatty-liver disease; fructose;
   oxidative stress; inflammation; fatty acid biosynthesis
ID URIC-ACID; SUPEROXIDE-DISMUTASE; DIETARY COPPER; LYSYL OXIDASE;
   DEFICIENCY; FRUCTOSE; REVEALS; IRON; RAT; INSULIN
AB The essential transition metal copper is important in lipid metabolism, redox balance, iron mobilization, and many other critical processes in eukaryotic organisms. Genetic diseases where copper homeostasis is disrupted, including Menkes disease and Wilson disease, indicate the importance of copper balance to human health. The severe consequences of insufficient copper supply are illustrated by Menkes disease, caused by mutation in the X-linked ATP7A gene encoding a protein that transports copper from intestinal epithelia into the bloodstream and across the blood-brain barrier. Inadequate copper supply to the body due to poor diet quality or malabsorption can disrupt several molecular level pathways and processes. Though much of the copper distribution machinery has been described and consequences of disrupted copper handling have been characterized in human disease as well as animal models, physiological consequences of sub-optimal copper due to poor nutrition or malabsorption have not been extensively studied. Recent work indicates that insufficient copper may be important in a number of common diseases including obesity, ischemic heart disease, and metabolic syndrome. Specifically, marginal copper deficiency (CuD) has been reported as a potential etiologic factor in diseases characterized by disrupted lipid metabolism such as non-alcoholic fatty-liver disease (NAFLD). In this review, we discuss the available data suggesting that a significant portion of the North American population may consume insufficient copper, the potential mechanisms by which CuD may promote lipid biosynthesis, and the interaction between CuD and dietary fructose in the etiology of NAFLD. (C) 2017 IUBMB Life
C1 [Morrell, Austin; Tallino, Savannah; Burkhead, Jason L.] Univ Alaska Anchorage, Dept Biol Sci Anchorage, Anchorage, AK 99508 USA.
   [Yu, Lei] Univ Washington, Sch Med, Dept Med, Div Gastroenterol, Seattle, WA 98195 USA.
C3 University of Alaska System; University of Alaska Anchorage; University
   of Washington; University of Washington Seattle
RP Burkhead, JL (corresponding author), Univ Alaska Anchorage, Dept Biol Sci Anchorage, Anchorage, AK 99508 USA.
EM jlburkhead@alaska.edu
RI Burkhead, Jason/C-9612-2013
OI Burkhead, Jason/0000-0001-5457-311X
FU Institutional Development Award (IDeA) from the National Institute of
   General Medical Sciences of the National Institutes of Health
   [P20GM103395]
FX Research reported in this publication was supported by an Institutional
   Development Award (IDeA) from the National Institute of General Medical
   Sciences of the National Institutes of Health under grant number
   P20GM103395. The content is solely the responsibility of the authors and
   does not necessarily reflect the official views of the NIH. Authors
   thank Sarah Brunjes- Hall for assistance with figure design.
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NR 77
TC 81
Z9 93
U1 0
U2 31
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1521-6543
EI 1521-6551
J9 IUBMB LIFE
JI IUBMB Life
PD APR
PY 2017
VL 69
IS 4
BP 263
EP 270
DI 10.1002/iub.1613
PG 8
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA ER1SW
UT WOS:000398574700007
PM 28271632
OA Bronze, Green Accepted
DA 2025-06-11
ER

PT J
AU Camargos, AC
   Mendonça, VA
   de Andrade, CA
   Oliveira, KSC
   Tossige-Gomes, R
   Rocha-Vieira, E
   Neves, CDC
   Vieira, EL
   Leite, HR
   Oliveira, MX
   Teixeira, AL
   Coimbra, CC
   Lacerda, ACR
AF Resende Camargos, Ana Cristina
   Mendonca, Vanessa Amaral
   de Andrade, Camila Alves
   Caires Oliveira, Katherine Simone
   Tossige-Gomes, Rosalina
   Rocha-Vieira, Etel
   Cunha Neves, Camila Danielle
   Marciano Vieira, Erica Leandro
   Leite, Hercules Ribeiro
   Oliveira, Murilo Xavier
   Teixeira Junior, Antonio Lucio
   Coimbra, Candido Celso
   Lacerda, Ana Cristina Rodrigues
TI Neuroendocrine Inflammatory Responses in Overweight/Obese Infants
SO PLOS ONE
LA English
DT Article
ID CARDIOVASCULAR RISK-FACTORS; ADIPOSE-TISSUE BIOLOGY;
   HIGH-MOLECULAR-WEIGHT; OBESE CHILDREN; OXIDATIVE STRESS; METABOLIC
   SYNDROME; NEUROTROPHIC FACTOR; CHILDHOOD OBESITY; BREAST-MILK;
   ADIPONECTIN
AB Childhood obesity is related to a cascade of neuroendocrine inflammatory changes. However, there remains a gap in the current literature regarding the possible occurrence of these changes in overweight/obese infants. The objective of this study was to evaluate adipokines, cortisol, brain-derived neurotrophic factor (BDNF) and redox status in overweight/obese infants versus normal-weight peers. A cross-sectional study was conducted with 50 infants (25 in the overweight/obese group and 25 in the normal-weight group) between 6 and 24 months. Plasma levels of leptin, adiponectin, resistin, soluble tumor necrosis factor (TNF) receptors, chemokines, BDNF, serum cortisol and redox status were measured. Unpaired Student's t-test was used to analyze the results and a probability of p<0.05 was acceptable for rejection of the null hypothesis. The Pearson correlation was used to verify the association between the biomarkers analyzed in each group. Plasma levels of leptin (p = 0.0001), adiponectin (p = 0.0007) and BDNF (p = 0.003), and serum cortisol (p = 0.048) were significantly higher in overweight/obese infants than normal-weight infants. In contrast, the concentration of thiobarbituric acid reactive substances (TBARS) (p = 0.004), and catalase (p = 0.045) and superoxide dismutase activity (p = 0.02) were lower in overweight/obese infants than normal-weight peers. All the results together indicate neuroendocrine inflammatory response changes in overweight/obese infants between 6 and 24 months. Although there is already an environment that predisposes for a subsequent pro-inflammatory response, neuroendocrine secretion changes that permit the control of the inflammatory process in this age interval can be observed.
C1 [Resende Camargos, Ana Cristina; Mendonca, Vanessa Amaral; de Andrade, Camila Alves; Caires Oliveira, Katherine Simone; Leite, Hercules Ribeiro; Oliveira, Murilo Xavier; Lacerda, Ana Cristina Rodrigues] Univ Fed Vales Jequitinhonha & Mucuri, Dept Fisioterapia, Diamantina, MG, Brazil.
   [Resende Camargos, Ana Cristina; Mendonca, Vanessa Amaral; Tossige-Gomes, Rosalina; Rocha-Vieira, Etel; Cunha Neves, Camila Danielle; Leite, Hercules Ribeiro; Lacerda, Ana Cristina Rodrigues] Soc Brasileira Fisiol, Programa Multicentr Posgrad Ciencias Fisiol, Diamantina, Brazil.
   [Marciano Vieira, Erica Leandro; Teixeira Junior, Antonio Lucio] Univ Fed Minas Gerais, Fac Med, Belo Horizonte, MG, Brazil.
   [Coimbra, Candido Celso] Univ Fed Minas Gerais, Inst Ciencias Biol, Belo Horizonte, MG, Brazil.
C3 Universidade Federal dos Vales do Jequitinhonha e Mucuri (UFVJM);
   Sociedade Brasileira de Fisiologia; Universidade Federal de Minas
   Gerais; Universidade Federal de Minas Gerais
RP Camargos, AC (corresponding author), Univ Fed Vales Jequitinhonha & Mucuri, Dept Fisioterapia, Diamantina, MG, Brazil.; Camargos, AC (corresponding author), Soc Brasileira Fisiol, Programa Multicentr Posgrad Ciencias Fisiol, Diamantina, Brazil.
EM anacristinarcamargos@gmail.com
RI Camargos, Ana/O-5993-2016; Vieira, Erica/A-1976-2013; Teixeira,
   Antonio/N-3315-2014; Neves, Camila/HWQ-6330-2023; Lacerda, Ana
   Cristina/J-2181-2012; Oliveira, Murilo Xavier/I-7346-2013; Ribeiro
   Leite, Hercules/GVT-1268-2022; Mendonca, Vanessa/T-7958-2019;
   Rocha-Vieira, Etel/A-2524-2017
OI Oliveira, Murilo Xavier/0000-0001-6358-4910; Ribeiro Leite,
   Hercules/0000-0001-8977-8131; Lacerda, Ana Cristina/0000-0001-5366-3754;
   Mendonca, Vanessa/0000-0002-1696-6091; Rocha-Vieira,
   Etel/0000-0001-6908-7237; Teixeira, Antonio Lucio/0000-0002-9621-5422
FU CNPq; FAPEMIG; CAPES
FX This work was supported by the Universidade Federal dos Vales do
   Jequitinhonha e Mucuri for institutional support, the CNPq, FAPEMIG, and
   CAPES for financial support and scholarships. The funder had no role in
   study design, data collection and analysis, decision to publish, or
   preparation of the manuscript. We thank the Universidade Federal dos
   Vales do Jequitinhonha e Mucuri for institutional support, the CNPq,
   FAPEMIG, and CAPES for financial support and scholarships. The authors
   are in debt to David Lee Nelson for kindly reading the manuscript.
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NR 60
TC 5
Z9 6
U1 0
U2 5
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD DEC 1
PY 2016
VL 11
IS 12
AR e0167593
DI 10.1371/journal.pone.0167593
PG 15
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA EE3JC
UT WOS:000389482700208
PM 27907172
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Xiang, H
   Wang, GJ
   Qu, JL
   Xia, SL
   Tao, XF
   Qi, B
   Zhang, QK
   Shang, D
AF Xiang, Hong
   Wang, Guijun
   Qu, Jialin
   Xia, Shilin
   Tao, Xufeng
   Qi, Bing
   Zhang, Qingkai
   Shang, Dong
TI Yin-Chen-Hao Tang Attenuates Severe Acute Pancreatitis in Rat: An
   Experimental Verification of In silico Network Target Prediction
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Article
DE Yin-Chen-Hao Tang; severe acute pancreatitis; inflammation; apoptosis;
   network target prediction; PPAR gamma; NF-kappa B
ID ELEVATED SERUM TRIGLYCERIDES; PERSISTENT ORGAN FAILURE; METABOLIC
   SYNDROME; HEPATIC-FIBROSIS; AR42J CELLS; KAPPA-B; PHARMACOLOGY;
   INHIBITION; IDENTIFICATION; APOPTOSIS
AB Yin-Chen-Hao Tang (YCHT) is a classical Chinese medicine compound that has a long history of clinical use in China for the treatment of inflammatory diseases. However, the efficacy and mechanisms of YCHT for the treatment of severe acute pancreatitis (SAP) are not known. The current study investigated the pharmacological properties of YCHT against SAP and its underlying mechanisms. A computational prediction of potential targets of YCHT was initially established based on a network pharmacology simulation. The model suggested that YCHT attenuated SAP progress by apoptosis inducement, anti-inflammation, anti-oxidation and blood lipid regulation. These effects were validated in SAP rats. YCHT administration produced the following results: (1) significantly inhibited the secretion of pancreatic enzymes and protected pancreatic tissue; (2) obviously increased the number of in situ terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL)-positive cells and induced apoptosis; (3) markedly inhibited neutrophil infiltration to the impaired pancreas and reduced the inflammatory reaction; (4) notably enhanced the activities of antioxidant enzymes and decreased the nitric oxide synthase levels; (5) significantly reduced the levels of triglycerides, total cholesterol and low-density lipoprotein and increased high-density lipoprotein; and (6) significantly up regulated peroxisome proliferator-activated receptor-gamma (PPAR gamma) and down regulated nuclear factor-kappa B (NF-kappa B). In summary, these results demonstrated that YCHT attenuated SAP progress by inducing apoptosis, repressing inflammation, alleviating oxidative stress and regulating lipid metabolism partially via regulation of the NEkB/PPARy signal pathway.
C1 [Xiang, Hong; Shang, Dong] Dalian Med Univ, Coll Inst Integrat Med, Dalian, Peoples R China.
   [Wang, Guijun] Jinzhou Med Univ, Dept Gen Surg, Affiliated Hosp 1, Jinzhou, Peoples R China.
   [Qu, Jialin; Xia, Shilin] Dalian Med Univ, Clin Lab Integrat Med, Affiliated Hosp 1, Dalian, Peoples R China.
   [Tao, Xufeng] Dalian Med Univ, Coll Pharm, Dalian, Peoples R China.
   [Qi, Bing; Zhang, Qingkai; Shang, Dong] Dalian Med Univ, Dept Gen Surg, Affiliated Hosp 1, Dalian, Peoples R China.
C3 Dalian Medical University; Jinzhou Medical University; Dalian Medical
   University; Dalian Medical University; Dalian Medical University
RP Shang, D (corresponding author), Dalian Med Univ, Coll Inst Integrat Med, Dalian, Peoples R China.; Shang, D (corresponding author), Dalian Med Univ, Dept Gen Surg, Affiliated Hosp 1, Dalian, Peoples R China.
EM shangdong@dmu.edu.cn
RI 祁, 兵/HGA-1468-2022
OI Xia, Shilin/0000-0003-1187-3192
FU National Natural Science Foundation of China [81373875]; Key Project
   Supported by Clinical Ability Construction of Liaoning Province
   [LNCCC-A03-2015]
FX This work was supported by grants from the National Natural Science
   Foundation of China (No. 81373875) and the Key Project Supported by
   Clinical Ability Construction of Liaoning Province (No. LNCCC-A03-2015).
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NR 46
TC 20
Z9 22
U1 0
U2 25
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA PO BOX 110, EPFL INNOVATION PARK, BUILDING I, LAUSANNE, 1015,
   SWITZERLAND
SN 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD OCT 13
PY 2016
VL 7
AR 378
DI 10.3389/fphar.2016.00378
PG 13
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA DY4HV
UT WOS:000385060500001
PM 27790147
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Khoury, T
   Ben Ya'acov, A
   Shabat, Y
   Zolotarovya, L
   Snir, R
   Ilan, Y
AF Khoury, Tawfik
   Ben Ya'acov, Ami
   Shabat, Yehudit
   Zolotarovya, Lidya
   Snir, Ram
   Ilan, Yaron
TI Altered distribution of regulatory lymphocytes by oral administration of
   soy-extracts exerts a hepatoprotective effect alleviating immune
   mediated liver injury, non-alcoholic steatohepatitis and insulin
   resistance
SO WORLD JOURNAL OF GASTROENTEROLOGY
LA English
DT Article
DE Non-alcoholic steatohepatitis; Fatty liver; Regulatory T cells; Soy;
   Type 2 diabetes; ConA hepatitis
ID IMPROVES ENDOTHELIAL FUNCTION; ENDOPLASMIC-RETICULUM STRESS; TYPE-2
   DIABETIC-PATIENTS; DIET-INDUCED OBESITY; HIGH-FAT DIET; T-CELLS;
   ASYMPTOMATIC PATIENTS; POSTMENOPAUSAL WOMEN; METABOLIC SYNDROME; HEPATIC
   STEATOSIS
AB AIM: To determine the immune-modulatory and the hepatoprotective effects of oral administration of two soy extracts in immune mediated liver injury and nonalcoholic steatohepatitis (NASH).
   METHODS: Two soy extracts, M1 and OS, were orally administered to mice with concanavalin A (ConA) immune-mediated hepatitis, to high-fat diet (HFD) mice and to methionine and choline reduced diet combined with HFD mice. Animals were followed for disease and immune biomarkers.
   RESULTS: Oral administration of OS and M1 had an additive effect in alleviating ConA hepatitis mani-fested by a decrease in alanine aminotransferase and aspartate aminotransferase serum levels. Oral administration of the OS and M1 soy derived fractions, ameliorated liver injury in the high fat diet model of NASH, manifested by a decrease in hepatic triglyceride levels, improvement in liver histology, decreased serum cholesterol and triglycerides and improved insulin resistance. In the methionine and choline reduced diet combined with the high fat diet model, we noted a decrease in hepatic triglycerides and improvement in blood glucose levels and liver histology. The effects were associated with reduced serum tumor necrosis factor alpha and alteration of regulatory T cell distribution.
   CONCLUSION: Oral administration of the combination of OS and M1 soy derived extracts exerted an adjuvant effect in the gut-immune system, altering the distribution of regulatory T cells, and alleviating immune mediated liver injury, hyperlipidemia and insulin resistance.
C1 [Khoury, Tawfik; Ben Ya'acov, Ami; Shabat, Yehudit; Zolotarovya, Lidya; Snir, Ram; Ilan, Yaron] Hadassah Hebrew Univ, Med Ctr, Dept Med, Gastroenterol Unit, IL-91120 Jerusalem, Israel.
   [Khoury, Tawfik; Ben Ya'acov, Ami; Shabat, Yehudit; Zolotarovya, Lidya; Snir, Ram; Ilan, Yaron] Hadassah Hebrew Univ, Med Ctr, Dept Med, Liver Unit, IL-91120 Jerusalem, Israel.
C3 Hebrew University of Jerusalem; Hadassah University Medical Center;
   Hebrew University of Jerusalem; Hadassah University Medical Center
RP Khoury, T (corresponding author), Hadassah Hebrew Univ, Med Ctr, Dept Med, Gastroenterol Unit, POB 12000, IL-91120 Jerusalem, Israel.
EM tawfikkhoury1@hotmail.com
FU Roaman-Epstein Liver Research Foundation
FX Supported by Grants from The Roaman-Epstein Liver Research Foundation
   (partly, to Ilan Y).
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NR 65
TC 21
Z9 22
U1 1
U2 6
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 8226 REGENCY DR, PLEASANTON, CA 94588 USA
SN 1007-9327
EI 2219-2840
J9 WORLD J GASTROENTERO
JI World J. Gastroenterol.
PD JUN 28
PY 2015
VL 21
IS 24
BP 7443
EP 7456
DI 10.3748/wjg.v21.i24.7443
PG 14
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA CL4LS
UT WOS:000356924900011
PM 26139990
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Lu, K
   Chen, J
   Wu, SL
   Chen, J
   Hu, DY
AF Lu, Kai
   Chen, Jia
   Wu, Shouling
   Chen, Ji
   Hu, Dayi
TI Interaction of Sleep Duration and Sleep Quality on Hypertension
   Prevalence in Adult Chinese Males
SO JOURNAL OF EPIDEMIOLOGY
LA English
DT Article
DE sleep duration; sleep quality; hypertension
ID GENDER-SPECIFIC ASSOCIATIONS; BLOOD-PRESSURE; INCIDENT HYPERTENSION;
   METABOLIC SYNDROME; NATIONAL-HEALTH; INSOMNIA; OBESITY; STRESS; RISK;
   DISORDERS
AB Background: Previous studies demonstrated conflicting results about the association of sleep duration and hypertension. Given the potential relationship between sleep quality and hypertension, this study aimed to investigate the interaction of self-reported sleep duration and sleep quality on hypertension prevalence in adult Chinese males.
   Methods: We undertook a cross-sectional analysis of 4144 male subjects. Sleep duration were measured by self-reported average sleep time during the past month. Sleep quality was evaluated using the standard Pittsburgh Sleep Quality Index. Hypertension was defined as blood pressure level >= 140/90 mm Hg or current antihypertensive treatment. The association between hypertension prevalence, sleep duration, and sleep quality was analyzed using logistic regression after adjusting for basic cardiovascular characteristics.
   Results: Sleep duration shorter than 8 hours was found to be associated with increased hypertension, with odds ratios and 95% confidence intervals (CIs) of 1.25 (95% CI, 1.03-1.52) for 7 hours, 1.41 (95% CI, 1.14-1.73) for 6 hours, and 2.38 (95% CI, 1.81-3.11) for <6 hours. Using very good sleep quality as the reference, good, poor, and very poor sleep quality were associated with hypertension, with odds ratios of 1.20 (95% CI, 1.01-1.42), 1.67 (95% CI, 1.32-2.11), and 2.32 (95% CI, 1.67-3.21), respectively. More importantly, further investigation of the association of different combinations of sleep duration and quality in relation to hypertension indicated an additive interaction.
   Conclusions: There is an additive interaction of poor sleep quality and short sleep duration on hypertension prevalence. More comprehensive measurement of sleep should be performed in future studies.
C1 [Lu, Kai; Chen, Jia; Hu, Dayi] Chongqing Med Univ, Affiliated Hosp 1, Dept Cardiol, Chongqing 400016, Peoples R China.
   [Wu, Shouling; Chen, Ji] Hebei United Univ, Kailuan Gen Hosp, Tangshan, Peoples R China.
C3 Chongqing Medical University; North China University of Science &
   Technology
RP Hu, DY (corresponding author), Chongqing Med Univ, Affiliated Hosp 1, Dept Cardiol, 1 Yixueyuan Rd, Chongqing 400016, Peoples R China.
EM dayihu2014@163.com
OI Lu, Kai/0000-0002-4332-0042
FU 12th Five-year Science and Technology Support Program of the Ministry of
   Science and Technology of China [2013BAI06B02]
FX This study was founded by grants from the 12th Five-year Science and
   Technology Support Program of the Ministry of Science and Technology of
   China (Grant No. 2013BAI06B02). We thank the staff of the Kailuan Study
   for their work in data collection.
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NR 52
TC 42
Z9 55
U1 1
U2 20
PU JAPAN EPIDEMIOLOGICAL ASSOC
PI TOKYO
PA HONGO MT BLDG, 4 FL, 7-2-2, HONGO, BUNKYO-KU, TOKYO, JAPAN
SN 0917-5040
J9 J EPIDEMIOL
JI J. Epidemiol.
PD JUN
PY 2015
VL 25
IS 6
BP 415
EP 422
DI 10.2188/jea.JE20140139
PG 8
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA CL4ZG
UT WOS:000356966900003
PM 25912096
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Ward, WO
   Kodavanti, UP
AF Ward, William O.
   Kodavanti, Urmila P.
TI Left ventricular gene expression profile of healthy and cardiovascular
   compromised rat models used in air pollution studies
SO INHALATION TOXICOLOGY
LA English
DT Article
DE Cardiac expression profiling; cardiovascular disease models; metabolic
   syndrome
ID SPONTANEOUSLY HYPERTENSIVE-RATS; INDUCED PULMONARY INJURY; PARTICULATE
   MATTER; DILATED CARDIOMYOPATHY; MYOCARDIAL-INFARCTION;
   CARDIAC-HYPERTROPHY; OXIDATIVE STRESS; WISTAR-KYOTO; INSULIN; DISEASE
AB The link between pollutant exposure and cardiovascular disease (CVD) has prompted mechanistic research with animal models of CVD. We hypothesized that the cardiac gene expression patterns of healthy and genetically compromised, CVD-prone rat models, with or without metabolic impairment, will reveal underlying disease processes that facilitate understanding of the mechanisms of air pollution susceptibility differences. Left ventricular gene expression was examined using Affymetrix rat 230A-gene arrays in male, age-matched (12-14 weeks old) healthy Wistar Kyoto (WKY) and CV-compromised spontaneously hypertensive (SH), stroke-prone SH (SHSP), obese SH heart failure (SHHF) and obese insulin-resistant (JCR) rats. Principle component analysis separated strains in three clusters: (1) WKY, (2) JCR and )3) SH, SHSP and SHHF. Gene expression pattern in JCR differed from all other CVD strains. Both SHHF and JCR strains presented the most differentially expressed genes from WKY, but generally with opposing directional pattern suggesting that the CVD in these strains arise through different mechanisms. Hierarchical clustering of nuclear factor-kappaB target genes indicated varying degrees of, but similar directional changes, in SH, SHSP and SHHF relative to WKY rats, which may relate to the severity of their CVD. The JCR strain had less pronounced expressions of these genes suggesting milder cardiac disease. No unique expression pattern could be identified for genes implicated in stroke and heart failure in SHSP and SHHF rats, respectively. The data show that the CVD pathophysiological mechanisms differ in models with different genetic backgrounds, and therefore, the mechanisms by which air pollutants affect the cardiopulmonary system are likely to vary.
C1 [Ward, William O.] US EPA, Biostat Core, Res Cores Unit, Natl Hlth & Environm Effects Res Lab,Off Res & De, Res Triangle Pk, NC 27709 USA.
   [Kodavanti, Urmila P.] US EPA, Environm Publ Hlth Div, Natl Hlth & Environm Effects Res Lab, Off Res & Dev, Res Triangle Pk, NC 27709 USA.
C3 United States Environmental Protection Agency; United States
   Environmental Protection Agency
RP Kodavanti, UP (corresponding author), US EPA, NHEERL, MD B105-02,109 TW Alexander Dr, Res Triangle Pk, NC 27709 USA.
EM kodavanti.urmila@epa.gov
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NR 61
TC 6
Z9 7
U1 0
U2 5
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0895-8378
EI 1091-7691
J9 INHAL TOXICOL
JI Inhal. Toxicol.
PD MAR 20
PY 2015
VL 27
SU 1
SI SI
BP 63
EP 79
DI 10.3109/08958378.2014.954171
PG 17
WC Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Toxicology
GA CY7PX
UT WOS:000366601900007
PM 26667332
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Zhang, Y
   Zang, J
   Wang, B
   Li, B
   Yao, XM
   Zhao, HY
   Li, W
AF Zhang, Yong
   Zang, Jing
   Wang, Bin
   Li, Bin
   Yao, Xiaomei
   Zhao, Hongyan
   Li, Wei
TI CD36 genotype associated with ischemic stroke in Chinese Han
SO INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
LA English
DT Article
DE Ischemic stroke; CD36; single nucleotide polymorphism; association
ID B SCAVENGER RECEPTOR; ACID TRANSLOCASE; OXIDIZED LDL; GENE; EXPRESSION;
   BRAIN; INJURY; HYPERLIPIDEMIA; ANGIOGENESIS; CONTRIBUTE
AB Objective: CD36 is involved in oxidant stress, hyperlipidemia, and thrombosis in the pathology of stroke. CD 36 single nucleotide polymorphisms (SNPs) were reported to be associated with abnormalities of serum FA, triglyceride level and to increase risk of metabolic syndrome, coronary artery disease and type 2 diabetes. Based on these finding we hypothesized that CD36 is an important candidate gene of stroke; therefore, we set out a case-control study to explore the association of CD36 SNPs with ischemic stroke. Methods: We enrolled 374 patients with atherothrombotic stroke as cases and 1,013 people without stroke as controls. CD36 rs3211842, rs3211870, rs1761667, rs9784998, and rs10499859 loci were detected by PCR-ligase detection reaction. Results: Only rs1761667 (P=0.042) and rs10499859 (P=0.038) polymorphisms were associated with cases of ischemic stroke. Under a dominant genetic model, logistic regression analysis revealed a 1.34-fold increased risk (95% CI 1.05-1.72) of ischemic stroke with rs1761667 A than non-A carriers (P=0.020); the adjusted odds ratio (AOR) was 1.38 (95% CI 1.06-1.78) after adjusting for the covariates age, gender, body mass index (BMI), cigarette smoking, hypertension, and diabetes. For rs10499859, the risk was increased 1.36-fold for G than non-G carriers (P=0.016), and the AOR was 1.39 (95% CI 1.08-1.81) (P=0.012). The 5 SNPs were in strong linkage disequilibrium. CD36 SNPs may have no association with plasma lipid levels and thromboxane B2 (TXB2) expression. Conclusion: CD36 rs1761667 and rs10499859 may indicate genetic susceptibility to ischemic stroke among Chinese Han.
C1 [Zhang, Yong; Yao, Xiaomei] Shandong Univ, Jinan Cent Hosp, Dept Neurol, Jinan 250013, Shandong, Peoples R China.
   [Zang, Jing] Rizhao Peoples Hosp, Dept Neurol, Jinan, Shandong, Peoples R China.
   [Wang, Bin; Li, Bin; Zhao, Hongyan; Li, Wei] Shandong Univ, Jinan Cent Hosp, Dept Geriatr, Jinan 250013, Shandong, Peoples R China.
C3 Shandong First Medical University & Shandong Academy of Medical
   Sciences; Shandong University; Shandong First Medical University &
   Shandong Academy of Medical Sciences; Shandong University
RP Zhang, Y (corresponding author), Shandong Univ, Jinan Cent Hosp, Dept Neurol, 105 Jiefang Rd, Jinan 250013, Shandong, Peoples R China.
EM yongzhang_yz@126.com
RI wang, bin/JEP-7906-2023; Li, Bin/JJG-0783-2023
FU National Natural Science Foundation of China [81070919]; Jinan Youth
   Science and Technology Grant
FX This study was supported by grants from the National Natural Science
   Foundation of China (No. 81070919), and Jinan Youth Science and
   Technology Grant.
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NR 34
TC 15
Z9 17
U1 0
U2 7
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 1940-5901
J9 INT J CLIN EXP MED
JI Int. J. Clin. Exp. Med.
PY 2015
VL 8
IS 9
BP 16149
EP 16157
PG 9
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA CW8TX
UT WOS:000365273300067
PM 26629128
DA 2025-06-11
ER

PT J
AU Hughes-Large, JM
   Pang, DKT
   Robson, DL
   Chan, P
   Toma, J
   Borradaile, NM
AF Hughes-Large, Jennifer M.
   Pang, Dominic K. T.
   Robson, Debra L.
   Chan, Pak
   Toma, Jelena
   Borradaile, Nica M.
TI Niacin receptor activation improves human microvascular endothelial cell
   angiogenic function during lipotoxicity
SO ATHEROSCLEROSIS
LA English
DT Article
DE Fatty acids; Lipids; Vascular disease; Obesity; Metabolic syndrome
ID PALMITATE-INDUCED APOPTOSIS; FREE-FATTY-ACIDS; PROTEIN-KINASE; VASCULAR
   INFLAMMATION; URINE PHARMACOKINETICS; OXIDATIVE STRESS; NICOTINIC-ACID;
   LIFE-SPAN; GPR109A; PHOSPHORIBOSYLTRANSFERASE
AB Objective: Niacin (nicotinic acid) as a monotherapy can reduce vascular disease risk, but its mechanism of action remains controversial, and may not be dependent on systemic lipid modifying effects. Niacin has recently been shown to improve endothelial function and vascular regeneration, independent of correcting dyslipidemia, in rodent models of vascular injury and metabolic disease. As a potential biosynthetic precursor for NAD(+), niacin could elicit these vascular benefits through NAD(+)-dependent, sirtuin (SIRT) mediated responses. Alternatively, niacin may act through its receptor, GPR109A, to promote endothelial function, though endothelial cells are not known to express this receptor. We hypothesized that niacin directly improves endothelial cell function during exposure to lipotoxic conditions and sought to determine the potential mechanism(s) involved. Methods and results: Angiogenic function in excess palmitate was assessed by tube formation following treatment of human microvascular endothelial cells (HMVEC) with either a relatively low concentration of niacin (10 mu M), or nicotinamide mononucleotide (NMN) (1 mu M), a direct NAD(+) precursor. Although both niacin and NMN improved HMVEC tube formation during palmitate overload, only NMN increased cellular NAD(+) and SIRT1 activity. We further observed that HMVEC express GRP109A. Activation of this receptor with either acifran or MK-1903 recapitulated niacin-induced improvements in HMVEC tube formation, while GPR109A siRNA diminished the effect of niacin. Conclusion: Niacin, at a low concentration, improves HMVEC angiogenic function under lipotoxic conditions, likely independent of NAD(+) biosynthesis and SIRT1 activation, but rather through niacin receptor activation. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
C1 [Hughes-Large, Jennifer M.; Pang, Dominic K. T.; Robson, Debra L.; Chan, Pak; Toma, Jelena; Borradaile, Nica M.] Univ Western Ontario, Schulich Sch Med & Dent, Dept Physiol & Pharmacol, London, ON N6A 5C1, Canada.
C3 Western University (University of Western Ontario)
RP Borradaile, NM (corresponding author), Univ Western Ontario, Schulich Sch Med & Dent, Dept Physiol & Pharmacol, London, ON N6A 5C1, Canada.
EM nica.borradaile@schulich.uwo.ca
OI Borradaile, Nica/0000-0001-6677-2175
FU Canadian Diabetes Association [OG-3-11-3339-NB]
FX This work was supported by a grant from the Canadian Diabetes
   Association (OG-3-11-3339-NB) to N.M.B.
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NR 59
TC 29
Z9 33
U1 0
U2 13
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0021-9150
EI 1879-1484
J9 ATHEROSCLEROSIS
JI Atherosclerosis
PD DEC
PY 2014
VL 237
IS 2
BP 696
EP 704
DI 10.1016/j.atherosclerosis.2014.10.090
PG 9
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA AW1RG
UT WOS:000346066600077
PM 25463108
DA 2025-06-11
ER

PT J
AU Guhanarayan, G
   Jablonski, J
   Witkowski, S
AF Guhanarayan, Gayatri
   Jablonski, Julianne
   Witkowski, Sarah
TI Circulating angiogenic cell population responses to 10 days of reduced
   physical activity
SO JOURNAL OF APPLIED PHYSIOLOGY
LA English
DT Article
DE endothelium; vascular repair; nitric oxide; cardiovascular regeneration;
   exercise; sedentary behavior
ID ENDOTHELIAL PROGENITOR CELLS; NITRIC-OXIDE SYNTHASE; CHRONIC ENDURANCE
   EXERCISE; CORONARY-ARTERY-DISEASE; CARDIOVASCULAR RISK; METABOLIC
   SYNDROME; BED REST; CD34(+) CELLS; T-CELLS; INACTIVITY
AB Circulating angiogenic cells (CACs) are a diverse group that have been identified as predictors of cardiovascular health and are inversely proportional to cardiovascular disease (CVD) outcomes. Inactivity is a growing concern in industrialized nations and is an independent risk factor for CVD. There is limited evidence regarding the impact of reduced physical activity (rPA) on different CAC populations. The purpose of this study was to evaluate the effect of objectively monitored rPA with maintained energy balance on two CAC populations (CFU and CD34(+) cells), intracellular nitric oxide (NOi), and genes related to NO production in active, healthy men. Participants (age 25 +/- 2.9 yr) refrained from structured physical activity for 10 days, which was reflected by a significant reduction in time in vigorous + very vigorous intensity activity (P = 0.03). Sedentary time tended to increase (P = 0.06) with rPA. CFU CACs have been characterized as mainly monocytic and lymphocytic cells. We found significant reductions in both the number of CFU CACs (-35.69%, P = 0.01) and CFU CAC NOi (-33.84%, P = 0.03). Neither NOi nor the number of CD34(+) cells, which are hematopoietic and endothelial progenitors, changed with rPA. We found no significant differences in NO-related gene expression or oxidative stress-related gene expression with rPA in either CAC type. Therefore, we conclude that although various CAC populations have been related to vascular health, regular physical activity is necessary to maintain CAC NOi and the vulnerability of CACs to short-term reductions in physical activity is population specific.
C1 [Guhanarayan, Gayatri; Jablonski, Julianne; Witkowski, Sarah] Univ Massachusetts, Dept Kinesiol, Amherst, MA 01003 USA.
C3 University of Massachusetts System; University of Massachusetts Amherst
RP Witkowski, S (corresponding author), Univ Massachusetts, Amherst, MA 01003 USA.
EM switkows@kin.umass.edu
RI Witkowski, Sarah/HNP-6959-2023
FU University of Massachusetts Amherst Faculty Research
FX Support for this study was provided by a University of Massachusetts
   Amherst Faculty Research grant to S. Witkowski.
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NR 61
TC 10
Z9 15
U1 0
U2 5
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 8750-7587
EI 1522-1601
J9 J APPL PHYSIOL
JI J. Appl. Physiol.
PD SEP 1
PY 2014
VL 117
IS 5
BP 500
EP 506
DI 10.1152/japplphysiol.00087.2014
PG 7
WC Physiology; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology; Sport Sciences
GA AO4LY
UT WOS:000341311400010
PM 25012029
DA 2025-06-11
ER

PT J
AU Marciniak, C
   Marechal, X
   Montaigne, D
   Neviere, R
   Lancel, S
AF Marciniak, Camille
   Marechal, Xavier
   Montaigne, David
   Neviere, Remi
   Lancel, Steve
TI Cardiac contractile function and mitochondrial respiration in
   diabetes-related mouse models
SO CARDIOVASCULAR DIABETOLOGY
LA English
DT Article
DE Metabolic syndrome; Diabetes; Heart; Mitochondria; Respiration;
   Streptozotocin; High-fat diet
ID HIGH-FAT DIET; INSULIN-RESISTANCE; OXIDATIVE STRESS; MICE; MELLITUS;
   OBESITY; STREPTOZOTOCIN; CARDIOMYOPATHY; DYSFUNCTION; HEART
AB Background: Pathophysiological processes underlying diabetic-related cardiomyopathies are complex. Mitochondria dysfunction is often described as a cause of cardiac impairment but its extent may depend on the type of experimental diabetes. Here we proposed to compare drug-or diet-induced models of diabetes in terms of metabolic features, cardiac and mitochondrial functions.
   Methods: Mice were fed with regular chow or fat-enriched diet. After three weeks, they received either citrate or streptozotocin injections for five consecutive days. Metabolic parameters, myocardial contractile function and mitochondrial respiration were measured after three more weeks. Fat mass volumes were assessed by magnetic resonance imaging. Oral glucose tolerance test, insulin tolerance test, triglyceride and adipocytokine quantification were evaluated to establish metabolic profiles. Cardiac function was assessed ex vivo onto a Langendorff column. Isolated cardiac mitochondria respiration was obtained using high-resolution oxygraphy.
   Results: Mice fed with the fat-enriched regimen presented abdominal obesity, increased blood glucose, elevated leptin level, glucose intolerance, and insulin resistance. Mice treated with streptozotocin, independently of the regimen, lost their capacity to release insulin in response to glucose ingestion. Mice fed with regular chow diet and injected with streptozotocin developed cardiac dysfunction without mitochondrial respiration defect. However, both groups of high-fat diet fed mice developed cardiac alterations associated with reduction in mitochondrial oxygen consumption, despite an increase in mitochondrial biogenesis signalling.
   Conclusions: We explored three animal models mimicking type 1 and 2 diabetes. While cardiac dysfunction was present in the three groups of mice, mitochondrial respiration impairment was only obvious in models reproducing features of type 2 diabetes.
C1 [Marciniak, Camille; Marechal, Xavier; Montaigne, David; Neviere, Remi; Lancel, Steve] Univ Lille 2, Fac Med, Dept Physiol, EA 4484, F-59045 Lille, France.
C3 Universite de Lille
RP Lancel, S (corresponding author), Univ Lille 2, Fac Med, Dept Physiol, EA 4484, 1 Pl Verdun, F-59045 Lille, France.
EM steve.lancel@univ-lille2.fr
RI LANCEL, Steve/H-9047-2019; Marechal, Xavier/R-5762-2018; montaigne,
   david/R-6066-2018
OI Neviere, Remi/0000-0002-7966-0110; Lancel, Steve/0000-0002-3292-5433;
   montaigne, david/0000-0002-2346-863X
FU Universite Lille2 - Ministere de l'Enseignement Superieur et de la
   Recherche [EA4484]; CPER - FEDER Region Nord Pas-de-Calais [08480265];
   Fondation de France [2009002501]; Fondation Coeur et Arteres [FCA09T6]
FX We thank Florent Auger-IMPRT114 for his technical assistance in 7-tesla
   MRI, Bernadette Lescure-IMPRT65 for adipocytokine determination. This
   work was supported by EA4484 - Universite Lille2 - Ministere de
   l'Enseignement Superieur et de la Recherche; CPER "cardiodiabete 2008" -
   FEDER Region Nord Pas-de-Calais 08480265; Fondation de France 2009002501
   and Fondation Coeur et Arteres FCA09T6.
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NR 50
TC 38
Z9 40
U1 0
U2 4
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1475-2840
J9 CARDIOVASC DIABETOL
JI Cardiovasc. Diabetol.
PD AUG 21
PY 2014
VL 13
AR 118
DI 10.1186/s12933-014-0118-7
PG 11
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism
GA AU1CM
UT WOS:000345358800001
PM 25142225
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Franco-Robles, E
   Campos-Cervantes, A
   Murillo-Ortiz, BO
   Segovia, J
   López-Briones, S
   Vergara, P
   Pérez-Vázquez, V
   Solís-Ortiz, MS
   Ramírez-Emiliano, J
AF Franco-Robles, Elena
   Campos-Cervantes, Alejandra
   Murillo-Ortiz, Blanca O.
   Segovia, Jose
   Lopez-Briones, Sergio
   Vergara, Paula
   Perez-Vazquez, Victoriano
   Solis-Ortiz, Martha S.
   Ramirez-Emiliano, Joel
TI Effects of curcumin on brain-derived neurotrophic factor levels and
   oxidative damage in obesity and diabetes
SO APPLIED PHYSIOLOGY NUTRITION AND METABOLISM-PHYSIOLOGIE APPLIQUEE
   NUTRITION ET METABOLISME
LA English
DT Article
DE curcumin; obesity; diabetes; BDNF; oxidative damage
ID INTIMA-MEDIA THICKNESS; CIRCULATING IMMUNE-COMPLEXES; OXIDIZED LDL;
   INSULIN-RESISTANCE; LIPID-PEROXIDATION; METABOLIC SYNDROME; BDNF
   EXPRESSION; STRESS; MICE; MOUSE
AB We evaluated the effects of curcumin treatment on protein oxidation (PO), lipid peroxidation (LP) and brain-derived neurotrophic factor (BDNF) levels in the hippocampus and frontal cortex (FC) of diabetic db/db mice (DM) and in sera of obese humans. Thus, DM were treated daily with 50 mg/kg of curcumin during an 8-week period. Obese human were treated daily with 500 and 750 mg of curcumin that was administered orally for 12 weeks; BDNF, PO and LP levels in sera were determined at in weeks 0, 2, 6 and 12 of treatment. BDNF levels decreased in hippocampus and FC of DM as compared with untreated wild-type mice. Curcumin improved or restored BDNF levels to normal levels in DM, but curcumin did not have any effect on BDNF levels in sera of obese humans. In hippocampus and FC of DM, hyperglycaemia and curcumin did not have effect on LP levels. Hyperglycaemia increased PO levels in hippocampus and FC, whereas curcumin decreased these levels in hippocampus but not in FC. In sera of obese humans, the 500-mg dose decreased LP levels in weeks 6 and 12 when compared with basal levels, but the 750-mg dose did not have any effect; both doses of curcumin decreased PO levels in weeks 2, 6 and 12 of treatment when compared with basal levels. Present results suggest a therapeutic potential of curcumin to decrease oxidation caused by obesity in humans and also show that curcumin restores BDNF levels in DM.
C1 [Franco-Robles, Elena; Campos-Cervantes, Alejandra; Lopez-Briones, Sergio; Perez-Vazquez, Victoriano; Solis-Ortiz, Martha S.; Ramirez-Emiliano, Joel] Univ Guanajuato, Dept Ciencias Med, Leon, Gto, Mexico.
   [Murillo-Ortiz, Blanca O.] Inst Mexicano Seguro Social, Unidad Med Alta Especialidad Bajio 1, Leon, Gto, Mexico.
   [Segovia, Jose; Vergara, Paula] CINVESTAV, Dept Fisiol Biofis & Neurociencias, Mexico City, DF, Mexico.
C3 Universidad de Guanajuato; Instituto Mexicano del Seguro Social;
   CINVESTAV - Centro de Investigacion y de Estudios Avanzados del
   Instituto Politecnico Nacional
RP Ramírez-Emiliano, J (corresponding author), Univ Guanajuato, Dept Ciencias Med, Leon, Gto, Mexico.
EM joelre@ugto.mx
RI Ortiz, Blanca/ABD-4523-2020; Segovia, Jose/C-9277-2011; FRANCO,
   ELENA/JCD-7806-2023; Briones, Sergio/AAE-5784-2021; Perez-Vazquez,
   Victoriano/B-5030-2010; Ramirez-Emiliano, Joel/A-9022-2019
OI Perez-Vazquez, Victoriano/0000-0001-9241-9084; FRANCO ROBLES,
   ELENA/0000-0003-0345-7578; Ramirez-Emiliano, Joel/0000-0001-9813-9120;
   Lopez-Briones, Sergio/0000-0003-0273-0958
FU CONACYT; PROMEP
FX This work was supported by Mexican grants from CONACYT and the PROMEP;
   ACC and EFR were CONACYT scholars.
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NR 54
TC 57
Z9 63
U1 0
U2 21
PU CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS
PI OTTAWA
PA 65 AURIGA DR, SUITE 203, OTTAWA, ON K2E 7W6, CANADA
SN 1715-5312
EI 1715-5320
J9 APPL PHYSIOL NUTR ME
JI Appl. Physiol. Nutr. Metab.
PD FEB
PY 2014
VL 39
IS 2
BP 211
EP 218
DI 10.1139/apnm-2013-0133
PG 8
WC Nutrition & Dietetics; Physiology; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics; Physiology; Sport Sciences
GA AA6GI
UT WOS:000331196400014
PM 24476477
DA 2025-06-11
ER

PT J
AU Dhar, I
   Dhar, A
   Wu, LY
   Desai, KM
AF Dhar, Indu
   Dhar, Arti
   Wu, Lingyun
   Desai, Kaushik M.
TI Increased Methylglyoxal Formation with Upregulation of Renin Angiotensin
   System in Fructose Fed Sprague Dawley Rats
SO PLOS ONE
LA English
DT Article
ID SMOOTH-MUSCLE-CELLS; OXIDATIVE STRESS; METABOLIC SYNDROME; DIABETIC
   COMPLICATIONS; INSULIN-RESISTANCE; HYPERTENSION DEVELOPMENT;
   CARDIOVASCULAR-DISEASE; MOLECULAR-MECHANISM; ALDOSTERONE SYSTEM;
   URIC-ACID
AB The current epidemic of obesity and type 2 diabetes is attributed to a high carbohydrate diet, containing mainly high fructose corn syrup and sucrose. More than two thirds of diabetic patients have hypertension. Methylglyoxal is a highly reactive dicarbonyl generated during glucose and fructose metabolism, and a major precursor of advanced glycation end products (AGEs). Plasma methylglyoxal levels are increased in hypertensive rats and diabetic patients. Our aim was to examine the levels of methylglyoxal, mediators of the renin angiotensin system and blood pressure in male Sprague-Dawley rats treated with a high fructose diet (60% of total calories) for 4 months. The thoracic aorta and kidney were used for molecular studies, along with cultured vascular smooth muscle cells (VSMCs). HPLC, Western blotting and Q-PCR were used to measure methylglyoxal and reduced glutathione (GSH), proteins and mRNA, respectively. Fructose treated rats developed a significant increase in blood pressure. Methylglyoxal level and protein and mRNA for angiotensin II, AT(1) receptor, adrenergic alpha(1D) receptor and renin were significantly increased, whereas GSH levels were decreased, in the aorta and/or kidney of fructose fed rats. The protein expression of the receptor for AGEs (RAGE) and NF-kappa B were also significantly increased in the aorta of fructose fed rats. MG treated VSMCs showed increased protein for angiotensin II, AT(1) receptor, and alpha(1D) receptor. The effects of methylglyoxal were attenuated by metformin, a methylglyoxal scavenger and AGEs inhibitor. In conclusion, we report a strong association between elevated levels of methylglyoxal, RAGE, NF-kappa B, mediators of the renin angiotensin system and blood pressure in high fructose diet fed rats.
C1 [Dhar, Indu; Dhar, Arti; Desai, Kaushik M.] Univ Saskatchewan, Coll Med, Dept Pharmacol, Saskatoon, SK S7N 0W0, Canada.
   [Wu, Lingyun] Lakehead Univ, Dept Hlth Sci, Thunder Bay, ON P7B 5E1, Canada.
   [Wu, Lingyun] Thunder Bay Reg Res Inst, Thunder Bay, ON, Canada.
C3 University of Saskatchewan; Lakehead University
RP Wu, LY (corresponding author), Lakehead Univ, Dept Hlth Sci, Thunder Bay, ON P7B 5E1, Canada.
EM lwu@lakeheadu.ca; k.desai@usask.ca
RI Wu, Lingyun/HRD-0014-2023
OI Dhar, Arti/0000-0003-1892-6875; DHAR, INDU/0000-0002-3096-8165; Desai,
   Kaushik/0000-0001-9355-4528
FU Heart and Stroke Foundation of Saskatchewan [G-10-DE-4379]; Saskatchewan
   Health Research Foundation
FX This work was supported by a grant-in-aid from the Heart and Stroke
   Foundation of Saskatchewan (G-10-DE-4379) to KD and LW, and by a New
   Investigator grant from the Saskatchewan Health Research Foundation to
   KD. The funders had no role in study design, data collection and
   analysis, decision to publish, or preparation of the manuscript.
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NR 40
TC 45
Z9 50
U1 0
U2 6
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD SEP 10
PY 2013
VL 8
IS 9
AR e74212
DI 10.1371/journal.pone.0074212
PG 7
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 259PK
UT WOS:000327538600076
PM 24040205
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Bombak, AE
   Bruce, SG
AF Bombak, Andrea E.
   Bruce, Sharon G.
TI Self-rated health and ethnicity: focus on indigenous populations
SO INTERNATIONAL JOURNAL OF CIRCUMPOLAR HEALTH
LA English
DT Article
DE self-rated health (SRH); ethnicity; indigenous health; health measures;
   surveys
ID MEXICAN-ORIGIN INDIVIDUALS; RISK-FACTORS; METABOLIC SYNDROME; REPORTED
   HEALTH; CHRONIC STRESS; SOCIOECONOMIC-STATUS; AFRICAN-AMERICAN;
   ALLOSTATIC LOAD; SOCIAL POSITION; WHITEHALL-II
AB Objectives. Self-rated health (SRH) is a commonly used measure in surveys to assess general health status or health-related quality of life. Differences have been detected in how different ethnic groups and nationalities interpret the SRH measure and assess their health. This review summarizes the research conducted on SRH within and between ethnic groups, with a focus on indigenous groups.
   Study design and methods. A search of published academic literature on SRH and ethnicity, including a comprehensive review of all relevant indigenous research, was conducted using PubMed and summarized.
   Results. A wide variety of research on SRH within ethnic groups has been undertaken. SRH typically serves as an outcome measure. Minority respondents generally rated their health worse than the dominant population. Numerous culturally-specific determinants of SRH have been identified. Cross-national and cross-ethnicity comparisons of the associations of SRH have been conducted to assess the validity of SRH. While SRH is a valid measure within a variety of ethnicities, differences in how SRH is assessed by ethnicities have been detected. Research in indigenous groups remains generally under-represented in the SRH literature.
   Conclusions. These results suggest that different ethnic groups and nationalities vary in SRH evaluations, interpretation of the SRH measure, and referents employed in rating health. To effectively assess and redress health disparities and establish culturally-relevant and effective health interventions, a greater understanding of SRH is required, particularly among indigenous groups, in which little research has been conducted.
C1 [Bombak, Andrea E.; Bruce, Sharon G.] Univ Manitoba, Dept Community Hlth Sci, Winnipeg, MB R3E 0W3, Canada.
C3 University of Manitoba
RP Bombak, AE (corresponding author), Univ Manitoba, Dept Community Hlth Sci, S113-750 Bannatyne Ave, Winnipeg, MB R3E 0W3, Canada.
EM umbombak@cc.umanitoba.ca
FU Manitoba Graduate Scholarship (MGS); Social Sciences and Humanities
   Research Council (SSHRC); Manitoba Health Research Council (MHRC);
   Western Regional Training Centre for Health Services Research (WRTC);
   MHRC; Canadian Institutes of Health Research (CIHR)
FX AB has received funding from the Manitoba Graduate Scholarship (MGS),
   Social Sciences and Humanities Research Council (SSHRC), Manitoba Health
   Research Council (MHRC), and Western Regional Training Centre for Health
   Services Research (WRTC). SB has received funding from MHRC and the
   Canadian Institutes of Health Research (CIHR). The authors have no
   conflict of interest to report.
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NR 97
TC 44
Z9 44
U1 0
U2 9
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1239-9736
EI 2242-3982
J9 INT J CIRCUMPOL HEAL
JI Int. J. Circumpolar Health
PY 2012
VL 71
AR 18538
DI 10.3402/ijch.v71i0.18538
PG 10
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA 998JC
UT WOS:000308232900002
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Fain, JN
   Tagele, BM
   Cheema, P
   Madan, AK
   Tichansky, DS
AF Fain, John N.
   Tagele, Balkachew M.
   Cheema, Paramjeet
   Madan, Atul K.
   Tichansky, David S.
TI Release of 12 Adipokines by Adipose Tissue, Nonfat Cells, and Fat Cells
   From Obese Women
SO OBESITY
LA English
DT Article
ID SERUM AMYLOID-A; MONOCYTE CHEMOATTRACTANT PROTEIN-1; METABOLIC SYNDROME;
   OXIDATIVE STRESS; LIPOPROTEIN LIPASE; MESSENGER-RNA; GROWTH-FACTOR;
   IN-VITRO; ADIPOCYTES; INFLAMMATION
AB The relative release in vitro of endothelin-1, zinc-alpha 2-glycoprotein (ZAG), lipocalin-2, CD14, RANTES (regulated on activation, normal T cell expressed and secreted protein), lipoprotein lipase (LPL), osteoprotegerin (OPG), fatty acid-binding protein 4 (FABP-4), visfatin/PBEF/Nampt, glutathione peroxidase-3 (GPX-3), intracellular cell adhesion molecule 1 (ICAM-1), and amyloid A was examined using explants of human adipose tissue as well as the nonfat cell fractions and adipocytes from obese women. Over a 48-h incubation the majority of the release of LPL was by fat cells whereas that of lipocalin-2, RANTES, and ICAM-1 was by the nonfat cells present in human adipose tissue. In contrast appreciable amounts of OPG, amyloid A, ZAG, FABP-4, GPX-3, CD14, and visfatin/PBEF/Nampt were released by both fat cells and nonfat cells. There was an excellent correlation (r = 0.75) between the ratios of adipokine release by fat cells to nonfat cells over 48 h and the ratio of their mRNAs in fat cells to nonfat cells at the start of the incubation. The total release of ZAG, OPG, RANTES, and amyloid A by incubated adipose tissue explants from women with a fat mass of 65 kg was not different from that by women with a fat mass of 29 kg. In contrast that of ICAM-1, FABP-4, GPX-3, visfatin/PBEF/Nampt, CD14, lipocalin-2, LP, and endothelin-1 was significantly greater in tissue from women with a total fat mass of 65 kg.
C1 [Fain, John N.; Cheema, Paramjeet] Univ Tennessee, Ctr Hlth Sci, Dept Mol Sci, Memphis, TN 38163 USA.
   [Tagele, Balkachew M.] Univ Tennessee, Ctr Hlth Sci, Dept Clin Lab Sci, Memphis, TN 38163 USA.
   [Madan, Atul K.; Tichansky, David S.] Univ Tennessee, Ctr Hlth Sci, Dept Surg, Memphis, TN 38163 USA.
C3 University of Tennessee System; University of Tennessee Health Science
   Center; University of Tennessee System; University of Tennessee Health
   Science Center; University of Tennessee System; University of Tennessee
   Health Science Center
RP Fain, JN (corresponding author), Univ Tennessee, Ctr Hlth Sci, Dept Mol Sci, Memphis, TN 38163 USA.
EM jfain@utmem.edu
FU Van Vleet Chair of Excellence; University of Tennessee; Zen-Bio Inc.
FX This research was supported by the Van Vleet Chair of Excellence,
   University of Tennessee and Zen-Bio Inc.
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NR 40
TC 40
Z9 43
U1 0
U2 2
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 1930-7381
J9 OBESITY
JI Obesity
PD MAY
PY 2010
VL 18
IS 5
BP 890
EP 896
DI 10.1038/oby.2009.335
PG 7
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 590OA
UT WOS:000277234800008
PM 19834460
OA Bronze
DA 2025-06-11
ER

PT J
AU Colombo, SL
   Moncada, S
AF Colombo, Sergio L.
   Moncada, Salvador
TI AMPKα1 regulates the antioxidant status of vascular endothelial cells
SO BIOCHEMICAL JOURNAL
LA English
DT Article
DE AMP-activated protein kinase alpha 1 (AMPK alpha 1); antioxidant; human
   umbilical-vein endothelial cell (HUVEC); hypoxia; mitochondrion; nitric
   oxide
ID ACTIVATED PROTEIN-KINASE; FATTY-ACID OXIDATION; NITRIC-OXIDE; BETA;
   CREB; EXPRESSION; PATHWAY; GLUCOSE; MITOCHONDRIA; STIMULATION
AB AMPK (AMP-activated protein kinase) is a key regulator of cellular energy because of its capacity to detect changes in the concentration of AMP. Recent evidence, however, indicates the existence of alternative mechanisms of activation of this protein. Mitochondrial ROS (reactive oxygen species), generated as a result of the interaction between nitric oxide and mitochondrial cytochrome c oxidase, activate AMPK alpha 1 in HUVECs (human umbilical-vein endothelial cells) at a low oxygen concentration (i.e. 3%). This activation is independent of changes in AMP. In the present Study we show, using HUVECs in which AMPK alpha 1 has been silenced, that this protein is responsible for the expression of genes involved in antioxidant defence, such as manganese superoxide dismutase, catalase, gamma-glutamylcysteine synthase and thioredoxin. Furthermore, peroxisome proliferator-activated-coactivator-1, cAMP-response-element-binding protein and Foxo3a (forkhead transcription factor 3a) are involved in this signalling pathway. In addition, we show that silencing AMPK alpha 1 in cells results in a reduced mitochondrial and eNOS (endothelial NO synthase) content, reduced cell proliferation, increased accumulation of ROS and apoptosis. Thus AMPK alpha 1 in HUVECs regulates both their mitochondrial content and their antioxidant defences. Pharmacological activation of AMPK alpha 1 in the vascular endothelium may be beneficial in conditions such as metabolic syndrome, Type 2 diabetes and atherosclerosis, not only because of its bioenergetic effects but also because of its ability to counteract oxidative stress.
C1 [Colombo, Sergio L.; Moncada, Salvador] UCL, Wolfson Inst Biomed Res, London WC1E 6AE, England.
C3 University of London; University College London
RP Moncada, S (corresponding author), UCL, Wolfson Inst Biomed Res, Gower St,Cruciform Bldg, London WC1E 6AE, England.
EM s.moncada@ucl.ac.uk
OI Colombo, Sergio/0000-0001-7360-986X
FU Wellcome Trust [086729]
FX This work was supported by the Wellcome Trust [grant number 086729 (to
   S. L. C. and S. M.)].
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NR 31
TC 158
Z9 168
U1 0
U2 14
PU PORTLAND PRESS LTD
PI LONDON
PA CHARLES DARWIN HOUSE, 12 ROGER STREET, LONDON WC1N 2JU, ENGLAND
SN 0264-6021
EI 1470-8728
J9 BIOCHEM J
JI Biochem. J.
PD JUL 15
PY 2009
VL 421
BP 163
EP 169
DI 10.1042/BJ20090613
PN 2
PG 7
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 471WD
UT WOS:000268088100003
PM 19442239
OA Green Published
DA 2025-06-11
ER

PT J
AU McCormick, KL
   Wang, XD
   Mick, GJ
AF McCormick, Kenneth L.
   Wang, Xudong
   Mick, Gail J.
TI Modification of microsomal 11β-HSD1 activity by cytosolic compounds::
   Glutathione and hexose phosphoesters
SO JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
LA English
DT Article
DE 11 beta-hydroxysteroid dehydrogenase; hexose phosphates; glutathione;
   microsome; redox
ID 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1; RAT-LIVER MICROSOMES;
   HEXOSE-6-PHOSPHATE DEHYDROGENASE; ENDOPLASMIC-RETICULUM; OXIDATIVE
   STRESS; ADIPOSE-TISSUE; GLUCOSE-6-PHOSPHATE TRANSPORT; DIABETIC
   COMPLICATIONS; METABOLIC SYNDROME; GLYCOGEN-SYNTHASE
AB 11 beta-Hydroxysteroid dehydrogenase1 (11 beta-HSD1) can serve either as an oxo-reductase or dehydrogenase determined by the redox state in the endoplasmic reticulum (ER). This bidirectional enzyme governs paracrine glucocorticoid production. Recent in vitro studies have underscored the key role of cytoplasmic glucose-6-phosphate (G6P) in controlling the flux direction of 11 beta HSD-1 by altering the intraluminal ER NADPH/NADP ratio. The hypothesis that other hexose phosphoesters or the plentiful cellular oxidative protector glutathione could also regulate microsomal 11 beta HSD-1 activity was tested. Fructose-6-phosphate increased the activity of 11 beta-HSD1 reductase in isolated rat and porcine liver microsomes but not porcine fat microsomes. Moreover, oxidized glutathione (GSSG) attenuated 11 beta-HSD1 reductase activity by 40% while reduced glutathione (GSH) activated the reductase in liver. Fat microsomes were unaffected because they lack glutathione reductase. Nonetheless, another oxidizing agent, hydrogen peroxide (0.5 mM), inhibited both fat and liver 11 beta-HSD1 reductase. Consistent with the major role of the redox state, 2.5 mM GSSG and hydrogen peroxide augmented the 11 beta-HSD1 dehydrogenase, antithetical to the reductase, by 20-30% in liver microsomes. Given the key role of reactive oxygen species and hexose phosphate accumulation in the pathoetiology of obesity and diabetes, these compounds might also modify 11 beta-HSD1 in these conditions. (C) 2008 Elsevier Ltd. All rights reserved.
C1 [McCormick, Kenneth L.; Wang, Xudong; Mick, Gail J.] Univ Alabama Birmingham, Div Pediat Endocrinol & Diabet, Birmingham, AL 35233 USA.
C3 University of Alabama System; University of Alabama Birmingham
RP McCormick, KL (corresponding author), 1601 4th Ave S,CPP 230, Birmingham, AL 35233 USA.
EM kmccormick@peds.uab.edu
RI Wang, Xu-Dong/Z-1721-2019
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NR 61
TC 10
Z9 10
U1 0
U2 0
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0960-0760
J9 J STEROID BIOCHEM
JI J. Steroid Biochem. Mol. Biol.
PD JUL
PY 2008
VL 111
IS 1-2
BP 18
EP 23
DI 10.1016/j.jsbmb.2008.04.003
PG 6
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 342NM
UT WOS:000258790800004
PM 18550363
DA 2025-06-11
ER

PT J
AU Shankar, A
   Li, JL
AF Shankar, Anoop
   Li, Jialiang
TI Association between serum gamma-glutamyltransferase level and
   prehypertension among US adults
SO CIRCULATION JOURNAL
LA English
DT Article
DE GGT; hypertension; NHANES; prehypertension
ID ARTERY RISK DEVELOPMENT; HIGH BLOOD-PRESSURE; CARDIOVASCULAR-DISEASE;
   METABOLIC SYNDROME; TRANSPEPTIDASE; HYPERTENSION; PREDICTOR; ALCOHOL;
   LIVER
AB Background Higher serum gamma-glutarnyltransferase (GGT) levels, a marker of oxidative stress, are implicated in the development and progression of hypertension; however, data from non-Caucasian ethnicities are limited. Also, currently there is little data available on the association between serum GGT level and clinically relevant blood pressure (BP) categories earlier in the disease continuum, when hypertension prevention efforts may be applicable. The association between serum GGT and prehypertension was examined in a nationally representative sample of US adults.
   Methods and Results Cross-sectional study among 5,827 National Health and Nutrition Examination Survey 1999-2002 participants aged :18 years without cardiovascular disease (CVD) and hypertension. The main outcome-of-interest was the presence of prehypertension (systolic BP 120-139 mmHg or diastolic BP 80-89 mmHg) (n=2,269). Higher serum GGT levels were positively associated with prehypertension, independent of smoking, waist circumference, diabetes, cholesterol levels and other confounders. The multivariable odds ratio (95% confidence intervals) comparing quartile 4 of GGT (> 29 U/L to quartile 1 (< 13 U/L) was 1.84 (1.37-2.46), p < 0.0001. This association persisted in separate analyses among men and women. The results were consistent in subgroup analyses by race-ethnicity, age, smoking, alcohol intake, body mass index, waist circumference and diabetes. In non-parametric models, the positive association between serum GGT and prehypertension appeared to be present across the full range of GGT, without any threshold effect.
   Conclusions Higher serum GGT levels are associated with prehypertension in a nationally representative sample of US adults, free of CVD and hypertension.
C1 Natl Univ Singapore, Dept Community Occupat & Family Med, Yong Loo Lin Sch Med, Singapore 117597, Singapore.
   Natl Univ Singapore, Dept Stat & Appl Probabil, Singapore 117597, Singapore.
C3 National University of Singapore; National University of Singapore
RP Shankar, A (corresponding author), Natl Univ Singapore, Dept Community Occupat & Family Med, Yong Loo Lin Sch Med, Block MD3,16 Med Dr, Singapore 117597, Singapore.
EM ashankar@nus.edu.sg
RI Li, Jialiang/N-8529-2019; Li, Jialiang/B-9132-2014
OI Li, Jialiang/0000-0002-9704-4135
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NR 27
TC 39
Z9 45
U1 0
U2 2
PU JAPANESE CIRCULATION SOC
PI TOYKO
PA 18TH FLOOR IMPERIAL HOTEL TOWER, 1-1-1 UCHISAIWAI-CHO CHIYODA-KU, TOYKO,
   100-0011, JAPAN
SN 1346-9843
EI 1347-4820
J9 CIRC J
JI Circ. J.
PD OCT
PY 2007
VL 71
IS 10
BP 1567
EP 1572
DI 10.1253/circj.71.1567
PG 6
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 215HQ
UT WOS:000249799400014
PM 17895553
OA Bronze
DA 2025-06-11
ER

PT J
AU Erdogan, D
   Gullu, H
   Caliskan, M
   Yildirim, I
   Ulus, T
   Bilgi, M
   Yilmaz, S
   Muderrisoglu, H
AF Erdogan, D
   Gullu, H
   Caliskan, M
   Yildirim, I
   Ulus, T
   Bilgi, M
   Yilmaz, S
   Muderrisoglu, H
TI Coronary flow reserve and coronary microvascular functions are strongly
   related to serum uric acid concentrations in healthy adults
SO CORONARY ARTERY DISEASE
LA English
DT Article
DE coronary artery disease; coronary flow reserve; Doppler
   echocardiography; uric acid
ID CARDIOVASCULAR RISK-FACTORS; C-REACTIVE PROTEIN; NONINVASIVE ASSESSMENT;
   XANTHINE-OXIDASE; HEART-DISEASE; NITRIC-OXIDE; DOPPLER-ECHOCARDIOGRAPHY;
   METABOLIC SYNDROME; VELOCITY RESERVE; ATHEROSCLEROSIS
AB Background Uric acid is a well known antioxidant; however, the relationship between serum uric acid levels and oxidative stress-caused disorders including cardiovascular diseases is not clear yet. Transthoracic Doppler echocardiographic measurement of coronary flow reserve is a useful too[ to investigate coronary flow reserve and coronary microvascular functions. In this study, we investigated the possible association between serum uric acid concentrations and coronary flow reserve in healthy adults.
   Methods One hundred healthy volunteers with normal uric acid levels, between 18 and 55 years of age, were included in this study. The study group was divided into two with regard to the serum uric acid levels. Coronary diastolic peak flow velocities were measured at baseline and after dipyridamole infusion (0.56 mg/kg over 4 min) using echocardiography.
   Results Coronary flow reserve and hyperemic mean peak flow velocity were significantly greater in participants with lower serum uric acid concentrations (<= 234 mu mol/l for women, <= 302 mu mol/l for men) than in those with higher serum uric acid concentrations (> 234 mu mol/l for women, > 302 mu mol/l for men) (2.91 +/- 0.5 vs. 2.47 +/- 0.5, P < 0.001; 66.8 +/- 11.4 vs. 61.1 +/- 16.5, P=0.04). The baseline mean peak flow velocity was significantly greater in participants with higher serum uric acid concentrations than in those with lower serum uric acid concentrations (24.7 +/- 4.1 vs. 23.1 +/- 2.4, P=0.02).
   Conclusion Lower serum uric acid concentrations might be regarded as indicative of coronary microvascular and conductance vessel functionality.
C1 Baskent Univ, Konya Teaching & Med Res Ctr, Dept Cardiol, Konya, Turkey.
   Baskent Univ, Konya Teaching & Med Res Ctr, Dept Nephrol, Konya, Turkey.
   Baskent Univ, Konya Teaching & Med Res Ctr, Dept Rheumatol, Konya, Turkey.
C3 Konya Egitim Training & Research Hospital; Baskent University; Konya
   Egitim Training & Research Hospital; Baskent University; Baskent
   University; Konya Egitim Training & Research Hospital
RP Baskent Univ, Konya Teaching & Med Res Ctr, Dept Cardiol, Konya, Turkey.
EM aydoganer@yahoo.com
RI YILMAZ, SERDAR/AAK-6462-2021; Bilgi, Muhammet/JAX-7104-2023; ERDOĞAN,
   DİLEK/AAL-1299-2020; Caliskan, Mustafa/JYO-9455-2024; YILDIRIM,
   İbrahim/HHC-1225-2022; Gullu, Hakan/IXD-5147-2023; MUDERRISOGLU, IBRAHIM
   HALDUN/AAG-8233-2020
OI Erdogan, Dogan/0009-0009-0675-099X; Gullu, Hakan/0000-0003-2579-9755;
   MUDERRISOGLU, IBRAHIM HALDUN/0000-0002-9635-6313
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NR 38
TC 18
Z9 20
U1 0
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0954-6928
EI 1473-5830
J9 CORONARY ARTERY DIS
JI Coronary Artery Dis.
PD FEB
PY 2006
VL 17
IS 1
BP 7
EP 14
DI 10.1097/00019501-200602000-00002
PG 8
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 998MV
UT WOS:000234323900002
PM 16374135
DA 2025-06-11
ER

PT J
AU Kurina, LM
   Weiss, LA
   Graves, SW
   Parry, R
   Williams, GH
   Abney, M
   Ober, C
AF Kurina, LM
   Weiss, LA
   Graves, SW
   Parry, R
   Williams, GH
   Abney, M
   Ober, C
TI Sex differences in the genetic basis of morning serum cortisol levels:
   Genome-wide screen identifies two novel loci specific to women
SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Article
ID D-MEDIATED TRANSCRIPTION; ADRENAL AXIS HORMONES; FOUNDER POPULATION;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; HEALTHY-SUBJECTS;
   PLASMA-CORTISOL; HERITAGE FAMILY; STRESS; SECRETION
AB Context: Relatively little is known about the influence of specific genes on cortisol levels, particularly morning cortisol levels.
   Objective: The objective of this study was to identify quantitative trait loci associated with morning serum cortisol levels.
   Design: We carried out a genome screen for morning serum cortisol using linkage and association methods tailored for use in large pedigrees. We conducted these analyses both in the whole sample and partitioned by sex.
   Setting: This study was conducted on nine communal Hutterite farms in South Dakota.
   Participants: The Hutterites are a young founder population who practice a communal, farming lifestyle in the western United States and in Canada. Hutterites (n = 504, 53% female) aged 11-89 yr from a single pedigree participated in this study.
   Main Outcome Measures: The main outcome measures were markers significantly linked or associated with variation in morning serum cortisol levels.
   Results: One genome-wide significant association was identified in the whole sample on 11p (D11S1981, P = 0.000092). Results of sex-partitioned analyses indicated that this association was restricted to females (females, P = 0.000084; males, P = 0.20). The 146-bp allele at this locus accounted for 7% of the variance in morning cortisol values in females, and females homozygous for the allele had an 89% increase in morning cortisol levels compared with female noncarriers. A second genome-wide significant association in females was identified on 14q (D14S74, P = 0.000091).
   Conclusions: Our results suggest that the genetic determinants of morning cortisol levels may be different for men and women and that loci on 11p and 14q influence morning cortisol levels in women.
C1 Univ Chicago, Dept Hlth Studies, Chicago, IL 60637 USA.
   Univ Chicago, Dept Human Genet, Chicago, IL 60637 USA.
   Univ Chicago, Dept Obstet & Gynecol, Chicago, IL 60637 USA.
   Brigham Young Univ, Dept Chem & Biochem, Provo, UT 84602 USA.
   Univ S Dakota, Sch Med, Sioux Falls, SD 57105 USA.
   Brigham & Womens Hosp, Cardiovasc Endocrinol Sect, Boston, MA 02115 USA.
   Harvard Univ, Sch Med, Boston, MA 02115 USA.
C3 University of Chicago; University of Chicago; University of Chicago;
   Brigham Young University; University of South Dakota; Harvard
   University; Harvard University Medical Affiliates; Brigham & Women's
   Hospital; Harvard University; Harvard Medical School
RP Univ Chicago, Dept Hlth Studies, 5841 S Maryland Ave,MC2007, Chicago, IL 60637 USA.
EM lkurina@uchicago.edu
OI Kurina, Lianne/0000-0002-2610-126X; Ober, Carole/0000-0003-4626-9809
FU NHGRI NIH HHS [HG02899] Funding Source: Medline; NHLBI NIH HHS [HL66533]
   Funding Source: Medline; NIDDK NIH HHS [DK55889] Funding Source:
   Medline; NIMH NIH HHS [1F32MH069016-1] Funding Source: Medline
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NR 62
TC 25
Z9 29
U1 0
U2 4
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0021-972X
EI 1945-7197
J9 J CLIN ENDOCR METAB
JI J. Clin. Endocrinol. Metab.
PD AUG
PY 2005
VL 90
IS 8
BP 4747
EP 4752
DI 10.1210/jc.2005-0384
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 953HZ
UT WOS:000231068500048
PM 15941864
OA Bronze
DA 2025-06-11
ER

PT J
AU Mravec, B
   Szantova, M
AF Mravec, Boris
   Szantova, Maria
TI The role of the nervous system in liver diseases
SO HEPATOLOGY RESEARCH
LA English
DT Review
DE alcohol-associated liver disease; cholestatic liver diseases; cirrhosis;
   fatty liver disease; hepatitis; hepatocellular carcinoma; inflammation;
   parasympathetic nervous system; sensory nerves; stress; sympathetic
   nervous system; vagus nerve
ID HEPATIC REINNERVATION; METABOLIC SYNDROME; TRANSPLANTATION; INNERVATION;
   ASSOCIATION; DENERVATION; RESPONSES; CIRRHOSIS; CELLS
AB The nervous system significantly participates in maintaining homeostasis, and modulating repair and regeneration processes in the liver. Moreover, the nervous system also plays an important role in the processes associated with the development and progression of liver disease, and can either potentiate or inhibit these processes. The aim of this review is to describe the mechanisms and pathways through which the nervous system influences the development and progression of liver diseases, such as alcohol-associated liver disease, nonalcoholic fatty liver disease, cholestatic liver disease, hepatitis, cirrhosis, and hepatocellular carcinoma. Possible therapeutic implications based on modulation of signals transduction between the nervous system and the liver are also discussed.
   The nervous system maintains the homeostasis of liver tissue based on signals transmitted through the brain-liver axis. Based on these signals, the brain regulates the balance of activities of the components of the autonomic nervous system, whereas in physiological situations, the activity of the parasympathetic nervous system predominates. In the case of liver disease, the nervous system may potentiate the regenerative and reparative processes ongoing in the liver tissue. Through the vagus nerve, the brain can also suppress inflammation in liver tissue. However, in the case of increased sympathetic nerve activity, the nervous system may potentiate the progression of liver disease. The liver disease itself may also contribute to the increased sympathetic nerve activity by altered transmission of signals from the liver. An altered brain-liver axis may therefore represent a new therapeutic target in hepatology. image
C1 [Mravec, Boris] Comenius Univ, Inst Physiol, Fac Med, Sasinkova 2, Bratislava 81372, Slovakia.
   [Mravec, Boris] Slovak Acad Sci, Inst Expt Endocrinol, Biomed Res Ctr, Bratislava, Slovakia.
   [Szantova, Maria] Comenius Univ, Fac Med, Dept Internal Med 3, Bratislava, Slovakia.
C3 Comenius University Bratislava; Slovak Academy of Sciences; Slovak
   Academy of Sciences; Biomedical Research Center, SAS; Institute of
   Experimental Endocrinology, SAS; Comenius University Bratislava
RP Mravec, B (corresponding author), Comenius Univ, Inst Physiol, Fac Med, Sasinkova 2, Bratislava 81372, Slovakia.
EM boris.mravec@fmed.uniba.sk
FU Agentra na Podporu Vskumu a Vvoja [APVV-17-0090]; Research and
   Development Agency
FX This work was supported by the Research and Development Agency
   (APVV-17-0090).
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NR 74
TC 2
Z9 2
U1 4
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1386-6346
EI 1872-034X
J9 HEPATOL RES
JI Hepatol. Res.
PD NOV
PY 2024
VL 54
IS 11
BP 970
EP 980
DI 10.1111/hepr.14125
EA OCT 2024
PG 11
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA L1G8E
UT WOS:001329990100001
PM 39392763
OA Bronze
DA 2025-06-11
ER

PT J
AU Lubel, SY
   Dichtiar, R
   Sinai, T
   Keinan-Boker, L
AF Lubel, Shay Y.
   Dichtiar, Rita
   Sinai, Tali
   Keinan-Boker, Lital
TI Exposure to Holocaust is associated with chronic morbidity in older
   adults-Results from national health and nutrition surveys
SO JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
LA English
DT Article
DE chronic morbidity; Holocaust survivors; Mabat; nutrition; overall
   mortality
ID EUROPEAN-IMMIGRANTS; CANCER INCIDENCE; SURVIVORS; ISRAEL; RISK;
   HYPERTENSION; RESTRICTION; MORTALITY; DISEASES; STRESS
AB BackgroundAlthough studies have suggested that Holocaust survivors are more likely than their non-Holocaust-exposed counterparts to suffer from mental and chronic morbidity, methodology differences and potential confounders often compromise result replicability and external validity. We examined associations between Holocaust exposure and chronic morbidity, as well as overall risk of mortality.MethodsSociodemographic, health-related behavior and nutritional-intake data from two representative National Health and Nutrition Survey Ages 65 and Over-the 2005-2006 MABAT ZAHAV 1 (MZ1) and the 2014-2015 MZ2, including face-to-face interviews and anthropometric measurements-were analyzed. Demographic, health, nutritional and lifestyle characteristics, and exposure to the Holocaust were self-reported. Longitudinal data on overall mortality were obtained by linking the MZ1 population to the population registry dataset. Associations between Holocaust exposure and prevalence of chronic morbidity and risk factors were estimated by multivariable logistic regression analyses, and to risk of overall mortality by Cox regression analysis, both adjusted to significant covariates.ResultsAmong 2096 study participants aged 75.7 +/- 6.1 years, 47.0% male, 518 were Holocaust survivors. In the fully adjusted model, Holocaust exposure was associated with increased prevalence of heart disease (odds ratio [OR] 1.40, 95% confidence interval [CI] 1.07-1.83), metabolic syndrome (OR 2.28, CI 1.23-4.21), and stroke (OR 1.77, CI 1.17-2.69), but not cancer or osteoporosis. Holocaust exposure did not substantially affect the overall risk of mortality (hazard ratio 1.10, CI 0.92-1.32).ConclusionsFurther research is needed to understand the mechanisms governing long-term outcomes of exposure to acute physical or mental trauma.
C1 [Lubel, Shay Y.; Keinan-Boker, Lital] Univ Haifa, Fac Social Welf & Hlth Sci, Sch Publ Hlth, Haifa, Israel.
   [Lubel, Shay Y.; Dichtiar, Rita; Sinai, Tali; Keinan-Boker, Lital] Israel Minist Hlth, Israel Ctr Dis Control, Ramat Gan, Israel.
   [Sinai, Tali] Hebrew Univ Jerusalem, Robert H Smith Fac Agr Food & Environm, Sch Nutr Sci, Rehovot, Israel.
   [Sinai, Tali] Israel Minist Hlth, Nutr Res Dept, Israel Ctr Dis Control, Sheba Med Ctr, Gertner Bldg, IL-5262100 Ramat Gan, Israel.
C3 University of Haifa; Ministry of Health - Israel; Hebrew University of
   Jerusalem; Chaim Sheba Medical Center; Tel Aviv University; Ministry of
   Health - Israel
RP Sinai, T (corresponding author), Israel Minist Hlth, Nutr Res Dept, Israel Ctr Dis Control, Sheba Med Ctr, Gertner Bldg, IL-5262100 Ramat Gan, Israel.
EM tali.sinai@mail.huji.ac.il
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NR 35
TC 1
Z9 1
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0002-8614
EI 1532-5415
J9 J AM GERIATR SOC
JI J. Am. Geriatr. Soc.
PD MAY
PY 2024
VL 72
IS 5
BP 1491
EP 1500
DI 10.1111/jgs.18875
EA MAR 2024
PG 10
WC Geriatrics & Gerontology; Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA QM4I4
UT WOS:001190688600001
PM 38529878
OA hybrid
DA 2025-06-11
ER

PT J
AU Rogalski, J
   Tomczak, T
AF Rogalski, Jakub
   Tomczak, Tomasz
TI Ferroptosis as a potential connection between schizophrenia and
   metabolic dysfunction-associated steatotic liver disease - a narrative
   review
SO POSTEPY PSYCHIATRII I NEUROLOGII
LA English
DT Article
DE schizophrenia; iron; ferroptosis; MASLD.
ID OXIDATIVE STRESS; NUTRITIONAL INTAKE; PRACTICE GUIDANCE; HIGH-FAT;
   ANTIPSYCHOTICS; HALOPERIDOL; MANAGEMENT; ROLES; DIET; INFLAMMATION
AB Purpose: Schizophrenia is a chronic condition that is associated with various comorbidities, including metabolic ones. Particular attention has been paid to the metabolic dysfunction-associated steatotic liver disease (MASLD), the liver equivalent of the metabolic syndrome. It is postulated that ferroptosis, a form of novel cell death connected with iron overload and lipid peroxidation, may be an interplaying factor in both of these conditions. This review aims to show the specific role of ferroptosis in the development and possible progression of MASLD among patients with schizophrenia. It will be accompanied by a consideration of the probable causes of the associations that occur. Views: Scientific reports suggest that there may be a genetic predisposition, in terms of ferroptosis, to the development of both schizophrenia and MASLD. Moreover, the role of poor dietary habits, specifically a high-fat diet and insufficient antioxidant intake, in excessive lipid peroxidation and iron overload is emphasized. Additionally, intestinal permeability, caused by iron overload, may contribute to a state of inflammation within the liver tissue. Finally, we cannot forget about the impact of antipsychotic drugs on the ferroptosis process - some of them may initiate this process through carbohydrate-lipid metabolism dysregulation, or causing hepatocyte iron overload, as well as disturbing cellular redox balance. Conclusions: The process of ferroptosis should be considered as one of the possible pathways which predispose a group of patients with schizophrenia to the development and progression of MASLD. Finding a possible marker of ferroptosis among the mentally ill population may be helpful in the identification of a subgroup of patients particularly vulnerable to steatotic liver disease.
C1 [Rogalski, Jakub] Med Univ Lodz, Mil Teaching & Vet Cent Hosp, 113 Zeromskiego St, PL-90549 Lodz, Poland.
   [Tomczak, Tomasz] Med Univ Lodz, Dept Child & Adolescent Psychiat, Lodz, Poland.
C3 Medical University Lodz; Medical University Lodz
RP Rogalski, J (corresponding author), Med Univ Lodz, Mil Teaching & Vet Cent Hosp, 113 Zeromskiego St, PL-90549 Lodz, Poland.
EM jakub.rogalski1@stud.umed.lodz.pl
RI Rogalski, Jakub/ISB-5966-2023
OI Rogalski, Jakub/0000-0002-7322-4844
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NR 97
TC 0
Z9 0
U1 0
U2 0
PU TERMEDIA PUBLISHING HOUSE LTD
PI POZNAN
PA KLEEBERGA 2, POZNAN, 61-615, POLAND
SN 1230-2813
J9 POSTEP PSYCHIATR NEU
JI POSTEP. PSYCHIATR. NEUROL.
PY 2024
VL 33
IS 3
BP 178
EP 187
DI 10.5114/ppn.2024.142136
PG 10
WC Psychiatry
WE Emerging Sources Citation Index (ESCI)
SC Psychiatry
GA U9Q6A
UT WOS:001415052000007
PM 39678457
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Yang, Z
   Han, XB
   Wang, KY
   Fang, J
   Wang, Z
   Liu, G
AF Yang, Zhao
   Han, Xuebing
   Wang, Keyu
   Fang, Jun
   Wang, Zheng
   Liu, Gang
TI Combined with multiplex and network analysis to reveal the key genes and
   mechanisms of nonalcoholic fatty liver disease
SO INTERNATIONAL IMMUNOPHARMACOLOGY
LA English
DT Article
DE High-fat diet; Diet-induced obesity mouse; Gene; Pathway; Network
ID COMPLEMENT-SYSTEM; HEPATIC STEATOSIS; OXIDATIVE STRESS; EXPRESSION;
   STEATOHEPATITIS; DYSFUNCTION; PROGRESSION; ACTIVATION; FIBROSIS
AB Background and Aims: Non-alcoholic fatty liver disease (NAFLD) has become a significant cause of chronic liver disease in developed countries, as a result of the worldwide trend of obesity and associated metabolic syndrome. Obesity and high-fat diet (HFD) are very common in patients with NAFLD. However, how to screen out key differentially expressed genes (DEGs) is a challenging task. The purpose of this study is to study the screen of key genes and pathways of HFD on the formation process of non-alcoholic fatty liver through network pharmacological analysis.Methods: In this study, 173 genes associated with NAFLD were collected from the Gene Expression Omnibus (GEO) database. To find significant genes and pathways, combine network clustering analysis, topology analysis, and pathway analysis.Results: The results showed that there were four key signaling pathways related to HFD, including complement cascade, Atorvastatin ADME, Asthma and Aflatoxin activation and detoxification. In addition, we identified six representative key genes, including Ccl5, Tlr2, Cd274, Cxcl10, Cxcl9 and Cd74, and screened three intersecting genes in Mus musculus and Homo sapiens sample, including C3, F2 and C7.Conclusions: In conclusion, our study constructed the NAFLD gene regulatory network of C57BL/6J mice for the first time and jointly analyzed the Mus musculus samples and Homo sapiens samples. It provides new insights for identifying potential biomarkers and valuable therapeutic clues, and puts forward a new method for web-based research. These findings may provide potential targets for early diagnosis, effective therapy and prognostic markers of NAFLD.
C1 [Yang, Zhao; Han, Xuebing; Wang, Keyu; Fang, Jun; Wang, Zheng; Liu, Gang] Hunan Agr Univ, Coll Biosci & Biotechnol, Changsha 410128, Hunan, Peoples R China.
   [Fang, Jun] Hunan Agr Univ, Changsha, Peoples R China.
C3 Hunan Agricultural University; Hunan Agricultural University
RP Fang, J (corresponding author), Hunan Agr Univ, Changsha, Peoples R China.
EM yzj991223@stu.hunau; xuebinghan@stu.hunau.edu.cn;
   wangkeyu@stu.hunau.edu.cn; fangjun1973@hunau.edu;
   wangkeyu@stu.hunau.edu.cn; gangle.liu@gmail.com
RI Liu, Gang/AAE-3853-2020; Wang, Zheng/GXA-0956-2022; Han,
   Xuebing/JFJ-4053-2023; Fang, Jian/G-3267-2011
FU Hunan Provincial Science and Technology Department [2021JJ30008,
   2020NK2004, 2019TP2004]; Double first-class construction project of
   Hunan Agricultural University [SYL201802003]; Postgraduate Scientific
   Research Innovation Project of Hunan Province [CX20210654]; Science and
   Technology Inno-vation and Entrepreneurship Project for University
   Students of Hunan Province [2021RC1004]
FX This study was supported by Hunan Provincial Science and Technology
   Department [2021JJ30008, 2020NK2004, 2019TP2004] , Double first-class
   construction project of Hunan Agricultural University [SYL201802003] ,
   Postgraduate Scientific Research Innovation Project of Hunan Province
   [CX20210654] and Science and Technology Innovation and Entrepreneurship
   Project for University Students of Hunan Province [2021RC1004] .
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NR 74
TC 4
Z9 5
U1 0
U2 17
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1567-5769
EI 1878-1705
J9 INT IMMUNOPHARMACOL
JI Int. Immunopharmacol.
PD OCT
PY 2023
VL 123
AR 110708
DI 10.1016/j.intimp.2023.110708
EA JUL 2023
PG 9
WC Immunology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Pharmacology & Pharmacy
GA P4CL8
UT WOS:001050141100001
PM 37523974
DA 2025-06-11
ER

PT J
AU Chaucheyras-Durand, F
   Sacy, A
   Karges, K
   Apper, E
AF Chaucheyras-Durand, Frederique
   Sacy, Audrey
   Karges, Kip
   Apper, Emmanuelle
TI Gastro-Intestinal Microbiota in Equines and Its Role in Health and
   Disease: The Black Box Opens
SO MICROORGANISMS
LA English
DT Review
DE equine; gastrointestinal tract; microbiota; dysbiosis; metabolism;
   Proteobacteria; fibrolytic bacteria
ID YEAST CULTURE SUPPLEMENTATION; HORSE SPECIES SYMPOSIUM; HIGH-FIBER;
   FECAL MICROBIOTA; LARGE-INTESTINE; SACCHAROMYCES-CEREVISIAE; BACTERIAL
   COMMUNITIES; GUT MICROBIOTA; FERMENTATION; DIVERSITY
AB Horses are large non-ruminant herbivores and rely on microbial fermentation for energy, with more than half of their maintenance energy requirement coming from microbial fermentation occurring in their enlarged caecum and colon. To achieve that, the gastro-intestinal tract (GIT) of horses harbors a broad range of various microorganisms, differing in each GIT segment, which are essential for efficient utilization of feed, especially to use nutrients that are not or little degraded by endogenous enzymes. In addition, like in other animal species, the GIT microbiota is in permanent interplay with the host's cells and is involved in a lot of functions among which inflammation, immune homeostasis, and energy metabolism. As for other animals and humans, the horse gut microbiome is sensitive to diet, especially consumption of starch, fiber, and fat. Age, breeds, stress during competitions, transportation, and exercise may also impact the microbiome. Because of its size and its complexity, the equine GIT microbiota is prone to perturbations caused by external or internal stressors that may result in digestive diseases like gastric ulcer, diarrhea, colic, or colitis, and that are thought to be linked with systemic diseases like laminitis, equine metabolic syndrome or obesity. Thus, in this review we aim at understanding the common core microbiome -in terms of structure and function- in each segment of the GIT, as well as identifying potential microbial biomarkers of health or disease which are crucial to anticipate putative perturbations, optimize global practices and develop adapted nutritional strategies and personalized nutrition.
C1 [Chaucheyras-Durand, Frederique; Sacy, Audrey; Apper, Emmanuelle] Lallemand SAS, F-31702 Blagnac, France.
   [Chaucheyras-Durand, Frederique] Univ Clermont Auvergne, UMR MEDIS, INRAE, F-63122 St Genes Champanelle, France.
   [Karges, Kip] Lallemand Special Inc, Milwaukee, WI 53218 USA.
C3 Lallemand - France; Universite Clermont Auvergne (UCA); INRAE
RP Apper, E (corresponding author), Lallemand SAS, F-31702 Blagnac, France.
EM eapper@lallemand.com
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NR 145
TC 28
Z9 29
U1 6
U2 21
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-2607
J9 MICROORGANISMS
JI Microorganisms
PD DEC
PY 2022
VL 10
IS 12
AR 2517
DI 10.3390/microorganisms10122517
PG 33
WC Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Microbiology
GA 7G9CR
UT WOS:000902813100001
PM 36557769
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Simeonova, R
   Shkondrov, A
   Kozuharova, E
   Ionkova, I
   Krasteva, I
AF Simeonova, Rumyana
   Shkondrov, Aleksandar
   Kozuharova, Ekaterina
   Ionkova, Iliana
   Krasteva, Ilina
TI A Study on the Safety and Effects of Amorpha fruticosa Fruit
   Extract on Spontaneously Hypertensive Rats with Induced Type 2 Diabetes
SO CURRENT ISSUES IN MOLECULAR BIOLOGY
LA English
DT Article
DE Amorpha fruticosa; invasive plants management; diabetes; hypertension
ID NATURAL-PRODUCTS; OXIDATIVE STRESS; MEDICINAL-PLANTS; AMORFRUTINS;
   RECEPTOR; TEA
AB Metabolic syndrome is characterized by a variety of diagnostic criteria: obesity, dyslipidemia, type 2 diabetes, and arterial hypertension. They contribute to the elevated risk of cardiovascular morbidity and mortality. The potential for Amorpha fruticosa L. (Fabaceae) to improve diabetes and metabolic disease is promising, based on in vitro tests. This is why a further investigation of the species is needed. Additionally, a toxicity review in relation to safety revealed that to date, there are no published data regarding the toxicity of A. fruticosa towards humans. This species could provide abundant and cheap resources because it is an aggressive invasive plant that grows almost unrestrictedly. The objective of this study was to evaluate the acute toxicity of a purified extract of A. fruticosa (EAF), and to assess its antioxidant, antihypertensive, and antihyperglycemic activity in streptozotocin-induced diabetic spontaneously hypertensive rats (SHRs). The EAF was slightly toxic (LD50 = 2121 mg/kg, b.w.) when administered orally, and moderately toxic (LD50 = 316 mg/kg, b.w.) at intraperitoneal administration, both in mice. The oral administration of EAF (100 mg/kg) for 35 days to SHRs caused significant decreases in the systolic pressure, blood glucose levels, and MDA quantity. It also increased the hepatic level of the endogenous antioxidant GSH, not only in diabetic SHRs, but also in the control group. An additional potential benefit to human health might be conferred through the environmental management of A. fruticosa based on its large-scale use for medicinal purposes, as this aggressive invasive species brings problems to natural habitats in many European countries.
C1 [Simeonova, Rumyana] Med Univ Sofia, Fac Pharm, Dept Pharmacol Pharmacotherapy & Toxicol, Sofia 1000, Bulgaria.
   [Shkondrov, Aleksandar; Kozuharova, Ekaterina; Ionkova, Iliana; Krasteva, Ilina] Med Univ Sofia, Fac Pharm, Dept Pharmacognosy, Sofia 1000, Bulgaria.
C3 Medical University Sofia; Medical University Sofia
RP Krasteva, I (corresponding author), Med Univ Sofia, Fac Pharm, Dept Pharmacognosy, Sofia 1000, Bulgaria.
EM rsimeonova@pharmfac.mu-sofia.bg; shkondrov@pharmfac.mu-sofia.bg;
   ina_kozuharova@yahoo.co.uk; ionkova@pharmfac.nat.bg;
   ikrasteva@pharmfac.mu-sofia.bg
RI Krasteva, Ilina/AFI-7757-2022; Simeonova, Rumyana/G-8002-2019;
   Kozuharova, PhD, DSc, Ekaterina/E-5498-2011; Shkondrov,
   Aleksandar/AER-5726-2022
OI Simeonova, Rumyana/0000-0003-4860-9053; Ionkova,
   Iliana/0000-0003-1411-7982; Krasteva, Ilina/0000-0001-8559-0369;
   Kozuharova, PhD, DSc, Ekaterina/0000-0001-6795-9660; Shkondrov,
   Aleksandar/0000-0001-5091-6058
FU Ministry of Education and Science of the Republic of Bulgaria
   [DO1-217/30.11.2018, DO1-278/03.12.2021]
FX This research was funded by the Ministry of Education and Science of the
   Republic of Bulgaria through the contract number DO1-217/30.11.2018
   (BioActiveMed), agreement number DO1-278/03.12.2021. The APC was funded
   by the same funder.
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NR 40
TC 7
Z9 7
U1 0
U2 6
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1467-3037
EI 1467-3045
J9 CURR ISSUES MOL BIOL
JI Curr. Issues Mol. Biol.
PD JUN
PY 2022
VL 44
IS 6
BP 2583
EP 2592
DI 10.3390/cimb44060176
PG 10
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 2M5HE
UT WOS:000817729300001
PM 35735617
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Hosseini, P
   Afzali, S
   Karimi, M
   Zandi, M
   Zebardast, A
   Latifi, T
   Tabibzadeh, A
   Ramezani, A
   Zakeri, A
   Zakeri, A
   Abedi, B
   Soltani, S
   Farahani, A
AF Hosseini, Parastoo
   Afzali, Shervin
   Karimi, Mohammadreza
   Zandi, Milad
   Zebardast, Arghavan
   Latifi, Tayebe
   Tabibzadeh, Alireza
   Ramezani, Akam
   Zakeri, Armin
   Zakeri, Amirmohammad
   Abedi, Behnam
   Soltani, Saber
   Farahani, Abbas
TI The coronavirus disease 2019 and effect on liver function: a hidden and
   vital interaction beyond the respiratory system
SO REVIEWS AND RESEARCH IN MEDICAL MICROBIOLOGY
LA English
DT Article
DE bilirubin; hepatitis; liver function test; prognosis; severe acute
   respiratory syndrome-related coronavirus 2; severe acute respiratory
   syndrome
ID C-REACTIVE PROTEIN; ANGIOTENSIN-CONVERTING ENZYME; PANDEMIC INFLUENZA-A;
   SERUM BILIRUBIN; BACTERIAL-INFECTION; INSULIN-RESISTANCE; METABOLIC
   SYNDROME; OXIDATIVE STRESS; APOPTOTIC CELLS; IMMUNE-RESPONSE
AB Severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) emerged in December 2019 in Wuhan province, China. SARS-CoV-2 causes coronavirus disease 2019 (COVID-19). Angiotensin-converting enzyme 2 (ACE2) has an essential role as a receptor in the entry of the SARS-CoV-2 into the host cells. It has been declared, ACE2 expresses in the lungs, heart, kidneys, placenta, and liver. This study reviews the liver's markers' characteristics in patients with COVID-19 to achieve novel insights in improving clinical treatment. Liver disease and chronic kidney disease patients are susceptible to COVID-19. There is limited information about the effects of SARS-COV-2 on patients with preexisting liver associated disorders, including chronic hepatitis B virus or hepatitis C virus, primary biliary cirrhosis, nonalcoholic fatty liver disease, and more are yet to be understood. By considering conducted studies in this manner since ACE2 receptors, which are the primary receptors for SRAS-CoV-2, exist on the liver and lungs, heart, kidneys, and placenta, SRAS-CoV-2 can infect liver cells too. Consequently, this infection will have resulted in liver function tests' escalated levels and total bilirubin as biochemical biomarkers. Further investigations need to be done to point out the hepatic manifestations of COVID-19's infected patients with chronic liver disease and improve clinical management and more stringent preventive measures for this type of infected patients. Copyright (C) 2021 Wolters Kluwer Health, Inc. All rights reserved.
C1 [Hosseini, Parastoo; Zandi, Milad; Zebardast, Arghavan; Latifi, Tayebe; Soltani, Saber] Univ Tehran Med Sci, Sch Publ Hlth, Dept Virol, Tehran, Iran.
   [Afzali, Shervin] Shahid Beheshti Univ, Fac Life Sci & Biotechnol, Dept Cellular & Mol Biol, Tehran, Iran.
   [Karimi, Mohammadreza; Ramezani, Akam] Univ Tehran Med Sci, Students Sci Res Ctr, Tehran, Iran.
   [Tabibzadeh, Alireza] Iran Univ Med Sci, Dept Virol, Tehran, Iran.
   [Zakeri, Armin] Tarbiat Modares Univ, Fac Med Sci, Dept Hematol, Tehran, Iran.
   [Zakeri, Amirmohammad] Shahid Beheshti Univ Med Sci, Pediat Surg Res Ctr, Res Inst Childrens Hlth, Tehran, Iran.
   [Abedi, Behnam] Khomein Univ Med Sci, Dept Med Lab, Khomein, Iran.
   [Farahani, Abbas] Hormozgan Univ Med Sci, Infect & Trop Dis Res Ctr, Hormozgan Hlth Inst, Bandar Abbas, Iran.
C3 Tehran University of Medical Sciences; Shahid Beheshti University;
   Tehran University of Medical Sciences; Iran University of Medical
   Sciences; Tarbiat Modares University; Shahid Beheshti University Medical
   Sciences
RP Farahani, A (corresponding author), Hormozgan Univ Med Sci, Infect & Trop Dis Res Ctr, Hormozgan Hlth Inst, Med Microbiol, Bandar Abbas, Iran.
EM abbasfarahani25@yahoo.com
RI Zebardast, Arghavan/AAR-9094-2021; soltani, saber/AAK-1616-2020; Zandi,
   Milad/Q-1167-2018; Tabibzadeh, Alireza/ABD-1787-2020; Farahani,
   Abbas/A-3046-2014
OI soltani, saber/0000-0003-3369-0856; Zandi, Milad/0000-0002-2145-0196;
   Farahani, Abbas/0000-0002-0245-2612; zebardast,
   arghavan/0000-0002-8263-241X; Hosseini, parastoo/0000-0003-2788-5796
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NR 226
TC 14
Z9 15
U1 0
U2 7
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 2770-3150
EI 2770-3169
J9 REV RES MED MICROBIO
JI Rev. Res. Med. Microbiol.
PD JAN
PY 2022
VL 33
IS 1
BP E161
EP E179
DI 10.1097/MRM.0000000000000267
PG 19
WC Microbiology
WE Emerging Sources Citation Index (ESCI)
SC Microbiology
GA XS3ST
UT WOS:000732833800029
OA Bronze
DA 2025-06-11
ER

PT J
AU Nicolson, GL
   de Mattos, GF
   Ash, M
   Settineri, R
   Escriba, PV
AF Nicolson, Garth L.
   Ferreira de Mattos, Gonzalo
   Ash, Michael
   Settineri, Robert
   Escriba, Pablo V.
TI Fundamentals of Membrane Lipid Replacement: A Natural Medicine Approach
   to Repairing Cellular Membranes and Reducing Fatigue, Pain, and Other
   Symptoms While Restoring Function in Chronic Illnesses and Aging
SO MEMBRANES
LA English
DT Article
DE membrane phospholipids; membrane structure; lipid transport; lipid
   oxidation; lipid exchange; mitochondrial function; fatigue; pain;
   chronic diseases
ID CANCER-RELATED FATIGUE; FLUID-MOSAIC MODEL; SOYBEAN-DERIVED
   PHOSPHATIDYLSERINE; HUMAN SKELETAL-MUSCLE; FREE-RADICAL THEORY;
   PROTEIN-KINASE-C; N-3 FATTY-ACIDS; OXIDATIVE STRESS; MITOCHONDRIAL
   DYSFUNCTION; METABOLIC SYNDROME
AB Membrane Lipid Replacement (MLR) uses natural membrane lipid supplements to safely replace damaged, oxidized lipids in membranes in order to restore membrane function, decrease symptoms and improve health. Oral MLR supplements contain mixtures of cell membrane glycerolphospholipids, fatty acids, and other lipids, and can be used to replace and remove damaged cellular and intracellular membrane lipids. Membrane injury, caused mainly by oxidative damage, occurs in essentially all chronic and acute medical conditions, including cancer and degenerative diseases, and in normal processes, such as aging and development. After ingestion, the protected MLR glycerolphospholipids and other lipids are dispersed, absorbed, and internalized in the small intestines, where they can be partitioned into circulating lipoproteins, globules, liposomes, micelles, membranes, and other carriers and transported in the lymphatics and blood circulation to tissues and cellular sites where they are taken in by cells and partitioned into various cellular membranes. Once inside cells, the glycerolphospholipids and other lipids are transferred to various intracellular membranes by lipid carriers, globules, liposomes, chylomicrons, or by direct membrane-membrane interactions. The entire process appears to be driven by 'bulk flow' or mass action principles, where surplus concentrations of replacement lipids can stimulate the natural exchange and removal of damaged membrane lipids while the replacement lipids undergo further enzymatic alterations. Clinical studies have demonstrated the advantages of MLR in restoring membrane and organelle function and reducing fatigue, pain, and other symptoms in chronic illness and aging patients.
C1 [Nicolson, Garth L.] Inst Mol Med, Dept Mol Pathol, Huntington Beach, CA 92647 USA.
   [Ferreira de Mattos, Gonzalo] Univ Republica, Fac Med, Dept Biophys, Lab Ion Channels Biol Membranes & Cell Signaling, Montevideo 11600, Uruguay.
   [Ash, Michael] Clin Educ, Newton Abbot TQ12 4SG, Devon, England.
   [Settineri, Robert] Sierra Prod Res, Mission Viejo, CA 92612 USA.
   [Escriba, Pablo V.] Univ Balear Isl, Lab Mol Cell Biomed, Palma de Mallorca 07122, Spain.
C3 Universidad de la Republica, Uruguay; Universitat de les Illes Balears
RP Nicolson, GL (corresponding author), Inst Mol Med, Dept Mol Pathol, Huntington Beach, CA 92647 USA.
EM gnicolson@immed.org; ferreira@fmed.edu.uy;
   michaelash@clinicaleducation.org; gnicolson3@immed.org;
   pablo.escriba@uib.es
RI Ferreira, Gonzalo/AAF-5749-2019
OI Ferreira, Gonzalo/0000-0002-4518-8698; Escriba,
   Pablo/0000-0001-9795-182X
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NR 328
TC 11
Z9 11
U1 1
U2 13
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2077-0375
J9 MEMBRANES-BASEL
JI Membranes
PD DEC
PY 2021
VL 11
IS 12
AR 944
DI 10.3390/membranes11120944
PG 39
WC Biochemistry & Molecular Biology; Chemistry, Physical; Engineering,
   Chemical; Materials Science, Multidisciplinary; Polymer Science
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry; Engineering; Materials
   Science; Polymer Science
GA XW3IZ
UT WOS:000735518600001
PM 34940446
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Halvorson, BD
   Whitehead, SN
   McGuire, JJ
   Wiseman, RW
   Frisbee, JC
AF Halvorson, Brayden D.
   Whitehead, Shawn N.
   McGuire, John J.
   Wiseman, Robert W.
   Frisbee, Jefferson C.
TI Endothelium-dependent impairments to cerebral vascular reactivity with
   type 2 diabetes mellitus in the Goto-Kakizaki rat
SO AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE
   PHYSIOLOGY
LA English
DT Article
DE cerebral circulation; metabolic disease; rat models of diabetes;
   vascular tone regulation
ID NITRIC-OXIDE; METABOLIC SYNDROME; OXIDATIVE STRESS; HEART-DISEASE;
   STROKE; MECHANISMS; ARTERIES; PATHOPHYSIOLOGY; RESISTANCE; EXPRESSION
AB Type 2 diabetes mellitus (T2DM) is a prevalent pathology associated with elevated cerebrovascular disease risk. We determined wall mechanics and vascular reactivity in ex vivo middle cerebral arteries (MCA) from male Goto-Kakizaki rats (GK; similar to 17 wk old) versus control Wistar Kyoto rats (WKY) to test the hypothesis that the diabetic environment in GK, in the absence of obesity and other comorbidities, leads to endothelial dysfunction and impaired vascular tone regulation. Dilation of MCA following challenge with acetylcholine and hypoxia was blunted in MCA from GK versus WKY, due to lower nitric oxide bioavailability and altered arachidonic acid metabolism, whereas myogenic activation and constrictor responses to serotonin were unchanged. MCA wall distensibility and cross-sectional area were not different between GK and WKY, suggesting that wall mechanics were unchanged at this age, supported by the determination that MCA dilation to sodium nitroprusside was also intact. With the use of ex vivo aortic rings as a bioassay, altered vascular reactivity determined in MCA was paralleled by relaxation responses in artery segments from GK, whereas measurements of vasoactive metabolite production indicated a loss of nitric oxide and prostacyclin bioavailability and an increased thromboxane A(2) production with both methacholine challenge and hypoxia. These results suggest that endothelium-dependent dilator reactivity of MCA in GK is impaired with T2DM, and that this impairment is associated with the genesis of a prooxidant/pro-inflammatory condition with diabetes mellitus. The restriction of vascular impairments to endothelial function only, at this age and development, provide insight into the severity of multimorbid conditions of which T2DM is only one constituent.
C1 [Halvorson, Brayden D.; McGuire, John J.; Frisbee, Jefferson C.] Univ Western Ontario, Schulich Sch Med & Dent, Dept Med Biophys, London, ON, Canada.
   [Whitehead, Shawn N.] Univ Western Ontario, Schulich Sch Med & Dent, Dept Anat & Cell Biol, London, ON, Canada.
   [Wiseman, Robert W.] Michigan State Univ, Dept Physiol, E Lansing, MI 48824 USA.
   [Wiseman, Robert W.] Michigan State Univ, Dept Radiol, E Lansing, MI 48824 USA.
C3 Western University (University of Western Ontario); Western University
   (University of Western Ontario); Michigan State University; Michigan
   State University
RP Frisbee, JC (corresponding author), Western Univ, Schulich Sch Med & Dent, Dept Med Biophys, MSB 407, London, ON N6A 5C1, Canada.
EM jfrisbee@uwo.ca
RI Halvorson, Brayden/IXN-1735-2023; Whitehead, Shawn/E-3772-2016
OI Frisbee, Jefferson/0000-0003-2751-0599; McGuire,
   John/0000-0003-0302-3884; Whitehead, Shawn/0000-0003-4728-8067
FU Canadian Institutes for Health Research [130138, 389769]; Natural
   Sciences and Engineering Research Council of Canada [RGPIN-2017-04536,
   RGPIN-2018-05450]; National Institute of Diabetes and Digestive and
   Kidney Diseases [NIH R01 DK-64668]; American Heart Association [EIA
   0740129N]
FX This work was supported by awards from the Canadian Institutes for
   Health Research (nos. 130138 and 389769), the Natural Sciences and
   Engineering Research Council of Canada (RGPIN-2017-04536 and
   RGPIN-2018-05450), the National Institute of Diabetes and Digestive and
   Kidney Diseases (NIH R01 DK-64668), and the American Heart Association
   (EIA 0740129N).
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NR 59
TC 12
Z9 14
U1 0
U2 5
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0363-6119
EI 1522-1490
J9 AM J PHYSIOL-REG I
JI Am. J. Physiol.-Regul. Integr. Comp. Physiol.
PD JUL
PY 2019
VL 317
IS 1
BP R149
EP R159
DI 10.1152/ajpregu.00088.2019
PG 11
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA IJ2AD
UT WOS:000475699700010
PM 31091154
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Kanter, JE
   Goodspeed, L
   Wang, S
   Kramer, F
   Wietecha, T
   Gomes-Kjerulf, D
   Subramanian, S
   O'Brien, KD
   den Hartigh, LJ
AF Kanter, Jenny E.
   Goodspeed, Leela
   Wang, Shari
   Kramer, Farah
   Wietecha, Tomasz
   Gomes-Kjerulf, Diego
   Subramanian, Savitha
   O'Brien, Kevin D.
   den Hartigh, Laura J.
TI 10,12 Conjugated Linoleic Acid-Driven Weight Loss Is Protective against
   Atherosclerosis in Mice and Is Associated with Alternative Macrophage
   Enrichment in Perivascular Adipose Tissue
SO NUTRIENTS
LA English
DT Article
DE alternatively activated macrophages; perivascular adipose tissue; type 2
   cytokines
ID ENDOTHELIAL-CELLS; OXIDATIVE STRESS; APOLIPOPROTEIN-E; DECREASES
   ATHEROSCLEROSIS; DIETARY-CHOLESTEROL; INTERLEUKIN-4; LIPOPROTEIN;
   APOE(-/-); ISOMERS; PLAQUE
AB The dietary fatty acid 10,12 conjugated linoleic acid (10,12 CLA) promotes weight loss by increasing fat oxidation, but its effects on atherosclerosis are less clear. We recently showed that weight loss induced by 10,12 CLA in an atherosclerosis-susceptible mouse model with characteristics similar to human metabolic syndrome is accompanied by accumulation of alternatively activated macrophages within subcutaneous adipose tissue. The objective of this study was to evaluate whether 10,12 CLA-mediated weight loss was associated with an atheroprotective phenotype. Male low-density lipoprotein receptor deficient (Ldlr(-/-)) mice were made obese with 12 weeks of a high-fat, high-sucrose diet feeding (HFHS: 36% fat, 36% sucrose, 0.15% added cholesterol), then either continued on the HFHS diet with or without caloric restriction (CR), or switched to a diet with 1% of the lard replaced by either 9,11 CLA or 10,12 CLA for 8 weeks. Atherosclerosis and lipid levels were quantified at sacrifice. Weight loss in mice following 10,12 CLA supplementation or CR as a weight-matched control group had improved cholesterol and triglyceride levels, yet only the 10,12 CLA-treated mice had improved en face and aortic sinus atherosclerosis. 10,12 CLA-supplemented mice had increased lesion macrophage content, with enrichment of surrounding perivascular adipose tissue (PVAT) alternative macrophages, which may contribute to the anti-atherosclerotic effect of 10,12 CLA.
C1 [Kanter, Jenny E.; Goodspeed, Leela; Wang, Shari; Kramer, Farah; Wietecha, Tomasz; Gomes-Kjerulf, Diego; Subramanian, Savitha; O'Brien, Kevin D.; den Hartigh, Laura J.] Univ Washington, Dept Med, Div Metab Endocrinol & Nutr, Med Diabet Inst, Box 358062,750 Republican St, Seattle, WA 98109 USA.
   [Wietecha, Tomasz; O'Brien, Kevin D.] Univ Washington, Dept Med, Cardiol, Box 356422,1959 Pacific Ave NE, Seattle, WA 98195 USA.
C3 University of Washington; University of Washington Seattle; University
   of Washington; University of Washington Seattle
RP den Hartigh, LJ (corresponding author), Univ Washington, Dept Med, Div Metab Endocrinol & Nutr, Med Diabet Inst, Box 358062,750 Republican St, Seattle, WA 98109 USA.
EM jenka@u.washington.edu; leelag@u.washington.edu;
   sawang@u.washington.edu; fkramer@u.washington.edu;
   tomaszw@u.washington.edu; gkjerulf@u.washington.edu;
   ssubrama@u.washington.edu; cardiac@u.washington.edu;
   lauradh@u.washington.edu
RI Kjerulf, Diego/C-4037-2014; Kramer, Frank/HGB-6558-2022; O'Brien,
   Kevin/HDO-1461-2022
OI Subramanian, Savitha/0000-0002-4866-2009; O'Brien,
   Kevin/0000-0002-2293-9196; Kanter, Jenny/0000-0003-3212-772X
FU NIH National Center for Complimentary and Integrative Health (NCCIH)
   [K01 AT007177]; NIH National Heart Lung and Blood Institute (NHLBI) [P01
   HL092969]; NIH National Institute for Diabetes and Digestive and Kidney
   Diseases (NIDDK) (University of Washington Nutrition Obesity Research
   Center Pilot and Feasibility Award) [P30 DK035816]; NIH National
   Institute for Diabetes and Digestive and Kidney Diseases (NIDDK)
   (University of Washington Diabetes Research Center Pilot and Feasibility
   Award) [P30 DK017047]; NIH National Institute for Diabetes and Digestive
   and Kidney Diseases (NIDDK) (University of Michigan Pilot and
   Feasibility Award) [U24 DK097153]
FX This work was supported by funding from the NIH National Center for
   Complimentary and Integrative Health (NCCIH, K01 AT007177), the NIH
   National Heart Lung and Blood Institute (NHLBI, P01 HL092969), and the
   NIH National Institute for Diabetes and Digestive and Kidney Diseases
   (NIDDK) (University of Washington Nutrition Obesity Research Center
   Pilot and Feasibility Award: P30 DK035816; University of Washington
   Diabetes Research Center Pilot and Feasibility Award: P30 DK017047; and
   University of Michigan Pilot and Feasibility Award: U24 DK097153).
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NR 57
TC 25
Z9 26
U1 0
U2 17
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD OCT
PY 2018
VL 10
IS 10
AR 1416
DI 10.3390/nu10101416
PG 14
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA GY7UM
UT WOS:000448821300082
PM 30282904
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Underdal, MO
   Stridsklev, S
   Oppen, IH
   Hogetveit, K
   Andersen, MS
   Vanky, E
AF Underdal, Maria Othelie
   Stridsklev, Solhild
   Oppen, Ingrid Hennum
   Hogetveit, Kristin
   Andersen, Marianne Skovsager
   Vanky, Eszter
TI Does Metformin Treatment During Pregnancy Modify the Future Metabolic
   Profile in Women With PCOS?
SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Article
ID POLYCYSTIC-OVARY-SYNDROME; WEIGHT-GAIN; FOLLOW-UP;
   CARDIOVASCULAR-DISEASE; RISK-FACTORS; PREVALENCE; OVERWEIGHT; CRITERIA;
   EXCESS; AGE
AB Context: Worldwide, metformin is prescribed to improve pregnancy outcome in polycystic ovary syndrome (PCOS). Metformin may also benefit future health by modulating increased metabolic stress during pregnancy.
   Objective: To investigate whether metformin during pregnancy modified future metabolic health in women with PCOS.
   Design: Follow-up study of a randomized controlled trial that compared metformin with placebo in women with PCOS. Mean follow-up period was 7.7 years (range, 5 to 11 years).
   Setting: Three university hospitals, seven local hospitals, and one gynecological specialist practice.
   Participants: Women with PCOS according to Rotterdam criteria; all former participants in the Metformin in Pregnant PCOS Women Study.
   Intervention: Metformin 2000 mg daily or placebo from first trimester to delivery in the original study. No intervention in the present follow-up study.
   Main Outcomes and Measures: Main outcome measure was weight gain in the follow-up period. Weight, body mass index (BMI), waist and hip circumferences, and blood pressure (BP) were registered. Body composition was assessed by bioelectrical impedance analysis, and fasting lipids, glucose, and insulin were analyzed.
   Results: Of 239 invited women, 131 (55%) participated in the follow-up. Weight gain was similar in women given metformin (2.1 +/- 10.5 kg) and women given placebo (1.8 +/- 11.2 kg) at 7.7 years' follow-up after pregnancy (P = 0.834). No difference was found in BMI, waist/hip ratio, BP, body composition, lipids, glucose and insulin levels, or prevalence of metabolic syndrome at follow-up between those treated with metformin and those treated with placebo during pregnancy.
   Conclusion: Metformin treatment during pregnancy did not influence the metabolic profile in women with PCOS at 7.7 years of follow-up.
C1 [Underdal, Maria Othelie; Stridsklev, Solhild; Vanky, Eszter] Norwegian Univ Sci & Technol, Dept Clin & Mol Med, Fac Med & Hlth Sci, N-7491 Trondheim, Norway.
   [Underdal, Maria Othelie; Stridsklev, Solhild; Vanky, Eszter] Univ Hosp Trondheim, St Olavs Hosp, Dept Obstet & Gynecol, N-7006 Trondheim, Norway.
   [Oppen, Ingrid Hennum; Hogetveit, Kristin] Norwegian Univ Sci & Technol, Fac Med & Hlth Sci, N-7030 Trondheim, Norway.
   [Andersen, Marianne Skovsager] Odense Univ Hosp, Endokrinol Afdeling M, Dept Internal Med, DK-5000 Odense C, Denmark.
C3 Norwegian University of Science & Technology (NTNU); Norwegian
   University of Science & Technology (NTNU); Norwegian University of
   Science & Technology (NTNU); University of Southern Denmark; Odense
   University Hospital
RP Underdal, MO (corresponding author), Univ Hosp Trondheim, Olav Kyrres Gt 16, N-7006 Trondheim, Norway.
EM maria.o.underdal@ntnu.no
RI Andersen, Marianne/AAE-1751-2019
OI Andersen, Marianne/0000-0002-4603-9504
FU Research Council of Norway; Felles Forskningsutvalg (Norwegian
   University of Science and Technology, Faculty of Medicine and Health
   Sciences/St. Olavs Hospital Trust); Novo Nordisk Foundation Norway
FX The Research Council of Norway and Felles Forskningsutvalg (Norwegian
   University of Science and Technology, Faculty of Medicine and Health
   Sciences/St. Olavs Hospital Trust) funded the present follow-up study
   (to M.O.U.). Novo Nordisk Foundation Norway supported the study (to
   M.O.U.). None of the funders had a role in the collection, analysis, and
   interpretation of data or in the writing of the primary reports from
   these studies or was in any way involved in this follow-up study of the
   women.
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NR 25
TC 15
Z9 16
U1 1
U2 8
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0021-972X
EI 1945-7197
J9 J CLIN ENDOCR METAB
JI J. Clin. Endocrinol. Metab.
PD JUN
PY 2018
VL 103
IS 6
BP 2408
EP 2413
DI 10.1210/jc.2018-00485
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA GI9WT
UT WOS:000434881400040
PM 29659896
OA Bronze, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Zhang, ZL
   Yao, Z
   Chen, YF
   Qian, L
   Jiang, SY
   Zhou, JY
   Shao, JJ
   Chen, AP
   Zhang, F
   Zheng, SZ
AF Zhang, Zili
   Yao, Zhen
   Chen, Yifan
   Qian, Lei
   Jiang, Shuoyi
   Zhou, Jingyi
   Shao, Jiangjuan
   Chen, Anping
   Zhang, Feng
   Zheng, Shizhong
TI Lipophagy and liver disease: New perspectives to better understanding
   and therapy
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Review
DE Lipophagy; Liver disease; Lipid droplets; Lipid metabolism; Therapeutic
   target
ID HEPATIC STELLATE CELL; ALCOHOLIC FATTY LIVER; ENDOPLASMIC-RETICULUM
   STRESS; IMPAIRED AUTOPHAGIC FLUX; HEPATOCELLULAR-CARCINOMA;
   LIPID-METABOLISM; MODULATING LIPOPHAGY; INSULIN-RESISTANCE; UPDATE 2016;
   RAT MODEL
AB Intracellular lipid droplets (LDs) are remarkably dynamic and complex organelles that enact regulated storage and release of lipids to fulfil their fundamental roles in energy metabolism, membrane synthesis and provision of lipid-derived signaling molecules. The recent finding that LDs can be selectively degraded by the lysosomal pathway of autophagy through a process termed lipophagy has opened up a new understanding of how lipid metabolism regulates cellular physiology and pathophysiology. Many new functions for autophagic lipid metabolism have now been defined in various diseases including liver disease. Lipophagy was originally described in hepatocytes, where it is critical for maintaining cellular energy homeostasis in obesity and metabolic syndrome. In vitro and in vivo studies have demonstrated the selective uptake of LDs by autophagosomes, and inhibition of autophagy has been shown to reduce the beta-oxidation of free fatty acids due to the increased accumulation of lipids and LDs. The identification of lipophagy as a new process dedicated to cellular lipid removal has mapped autophagy as an emerging player in cellular lipid metabolism. Pharmacological or genetic modulation of lipophagy might point to possible therapeutic strategies for combating a broad range of liver diseases. This review summarizes recent work focusing on lipophagy and liver disease as well as highlighting challenges and future directions of research. On the other hand, it also offers a glimpse into different strategies that have been used in experimental models to counteract excessive pathological lipophagy in the prevention and treatment of liver disease.
C1 [Zhang, Zili; Yao, Zhen; Chen, Yifan; Qian, Lei; Jiang, Shuoyi; Zhou, Jingyi; Shao, Jiangjuan; Zhang, Feng; Zheng, Shizhong] Nanjing Univ Chinese Med, Sch Pharm, Dept Pharmacol, Nanjing 210023, Jiangsu, Peoples R China.
   [Zhang, Feng; Zheng, Shizhong] Nanjing Univ Chinese Med, Jiangsu Key Lab Pharmacol & Safety Evaluat Chines, Nanjing 210023, Jiangsu, Peoples R China.
   [Zhang, Feng; Zheng, Shizhong] Nanjing Univ Chinese Med, Jiangsu Key Lab Therapeut Mat Chinese Med, Nanjing 210023, Jiangsu, Peoples R China.
   [Chen, Anping] St Louis Univ, Sch Med, Dept Pathol, St Louis, MO 63104 USA.
C3 Nanjing University of Chinese Medicine; Nanjing University of Chinese
   Medicine; Nanjing University of Chinese Medicine; Saint Louis University
RP Zheng, SZ (corresponding author), Nanjing Univ Chinese Med, Coll Pharm, Dept Pharmacol, 138 Xianlin Ave, Nanjing 210023, Jiangsu, Peoples R China.
EM nytws@163.com
RI Jingyi, Zhou/GPK-5338-2022; Chen, An-Ping/I-6455-2013; Chen,
   Yifan/AAA-1970-2020
OI Zheng, Shizhong/0000-0002-7092-7843
FU National Natural Science Foundation of China [81270514, 31571455,
   31401210, 31600653, 81600483]; Natural Science Foundation of Jiangsu
   Province [BK20140955]; Open Project Program of Jiangsu Key Laboratory
   for Pharmacology and Safety Evaluation of Chinese Materia Medica [JKLPSE
   201502]; Priority Academic Program Development of Jiangsu Higher
   Education Institutions (PAPD)
FX This work was supported by the National Natural Science Foundation of
   China (81270514, 31571455, 31401210, 31600653 and 81600483), the Natural
   Science Foundation of Jiangsu Province (BK20140955), the Open Project
   Program of Jiangsu Key Laboratory for Pharmacology and Safety Evaluation
   of Chinese Materia Medica (JKLPSE 201502), and the Project of the
   Priority Academic Program Development of Jiangsu Higher Education
   Institutions (PAPD). Finally, I sincerely thank my wife (Mei Guo) for
   her support and encouragement in a difficult period. Will you marry me
   and let me dearly love you with all my life?
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NR 96
TC 56
Z9 62
U1 3
U2 40
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI PARIS
PA 23 RUE LINOIS, 75724 PARIS, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD JAN
PY 2018
VL 97
BP 339
EP 348
DI 10.1016/j.biopha.2017.07.168
PG 10
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA FR4NC
UT WOS:000419041300044
PM 29091883
DA 2025-06-11
ER

PT J
AU Yiu, A
   Van Hemelrijck, M
   Garmo, H
   Holmberg, L
   Malmström, H
   Lambe, M
   Hammar, N
   Walldius, G
   Jungner, I
   Wulaningsih, W
AF Yiu, Andrew
   Van Hemelrijck, Mieke
   Garmo, Hans
   Holmberg, Lars
   Malmstrom, Hakan
   Lambe, Mats
   Hammar, Niklas
   Walldius, Goran
   Jungner, Ingmar
   Wulaningsih, Wahyu
TI Circulating uric acid levels and subsequent development of cancer in
   493,281 individuals: findings from the AMORIS Study
SO ONCOTARGET
LA English
DT Article
DE uric acid; cancer; prospective study
ID APOLIPOPROTEIN MORTALITY RISK; PROSPECTIVE MALE COHORT; ALL-CAUSE;
   LIPOPROTEIN COMPONENTS; MYOCARDIAL-INFARCTION; ANTIOXIDANT CAPACITY;
   METABOLIC SYNDROME; OXIDATIVE STRESS; SWEDISH AMORIS; A-I
AB Objectives: Serum uric acid has been suggested to be associated with cancer risk. We aimed to study the association between serum uric acid and cancer incidence in a large Swedish cohort.
   Results: A positive association was found between uric acid levels and overall cancer risk, and results were similar with adjustment for glucose, triglycerides and BMI. Hazard ratio (HR) for overall cancer for the 4th quartile of uric acid compared to the 1st was 1.08 (95% CI: 1.05-1.11) in men and 1.12 (1.09 - 1.16) in women. Site-specific analysis showed a positive association between uric acid and risk of colorectal, hepatobiliary, kidney, non-melanoma skin, and other cancers in men and of head and neck and other cancers in women. An inverse association was observed for pulmonary and central nervous system (CNS) cancers in men and breast, lymphatic and haematological, and CNS malignancies in women.
   Materials and Methods: We included 493,281 persons aged 20 years and older who had a measurement of serum uric acid and were cancer-free at baseline in the AMORIS study. Multivariable Cox proportional hazards regression was used to investigate sex-specific quartiles of serum uric acid in relation to cancer risk in men and women. Analysis was further adjusted for serum glucose, triglycerides and, where available, BMI. Site-specific analysis was performed for major cancers.
   Conclusions: Altered uric acid levels were associated with risk of overall and some specific cancers, further indicating the potential role of uric acid metabolism in carcinogenesis.
C1 [Yiu, Andrew; Van Hemelrijck, Mieke; Garmo, Hans; Holmberg, Lars; Wulaningsih, Wahyu] Kings Coll London, Div Canc Studies, Canc Epidemiol Grp, London, England.
   [Garmo, Hans; Holmberg, Lars] Reg Canc Ctr, Uppsala, Sweden.
   [Holmberg, Lars; Lambe, Mats] Uppsala Univ Hosp, Dept Surg Sci, Uppsala, Sweden.
   [Van Hemelrijck, Mieke; Malmstrom, Hakan; Hammar, Niklas] Karolinska Inst, Inst Environm Med, Unit Epidemiol, Stockholm, Sweden.
   [Lambe, Mats] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.
   [Hammar, Niklas] AstraZeneca R&D, Molndal, Sweden.
   [Walldius, Goran] Karolinska Inst, Inst Environm Med, Unit Cardiovasc Epidemiol, Stockholm, Sweden.
   [Jungner, Ingmar] Karolinska Inst, Clin Epidemiol Unit, Dept Med, Stockholm, Sweden.
   [Jungner, Ingmar] CALAB Res, Stockholm, Sweden.
C3 University of London; King's College London; Uppsala University; Uppsala
   University Hospital; Karolinska Institutet; Karolinska Institutet;
   AstraZeneca; Karolinska Institutet; Karolinska Institutet
RP Wulaningsih, W (corresponding author), Kings Coll London, Div Canc Studies, Canc Epidemiol Grp, London, England.
EM wahyu.wulaningsih@kcl.ac.uk
RI Wulaningsih, Wahyu/AAW-4307-2020
OI Van Hemelrijck, Mieke/0000-0002-7317-0858; Yiu,
   Andrew/0000-0002-1144-6927; Lambe, Mats/0000-0002-4624-3767
FU National Institute for Health Research (NIHR) Biomedical Research Centre
   based at Guy's and St Thomas' NHS Foundation Trust and King's College
   London; King's College London
FX The research was funded/supported by the National Institute for Health
   Research (NIHR) Biomedical Research Centre based at Guy's and St Thomas'
   NHS Foundation Trust and King's College London. Open access for this
   article was funded by King's College London.
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NR 43
TC 49
Z9 52
U1 1
U2 12
PU IMPACT JOURNALS LLC
PI ORCHARD PARK
PA 6666 E QUAKER ST, STE 1, ORCHARD PARK, NY 14127 USA
EI 1949-2553
J9 ONCOTARGET
JI Oncotarget
PD JUN 27
PY 2017
VL 8
IS 26
BP 42332
EP 42342
DI 10.18632/oncotarget.16198
PG 11
WC Oncology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Cell Biology
GA FA5OQ
UT WOS:000405493400049
PM 28418841
OA Green Submitted, gold, Green Published
DA 2025-06-11
ER

PT J
AU Sadowska, J
   Gebczynski, AK
   Konarzewski, M
AF Sadowska, Julita
   Gebczynski, Andrzej K.
   Konarzewski, Marek
TI Metabolic risk factors in mice divergently selected for BMR fed high fat
   and high carb diets
SO PLOS ONE
LA English
DT Article
ID SPONTANEOUS PHYSICAL-ACTIVITY; ENERGY-EXPENDITURE; FOOD-CONSUMPTION;
   OXIDATIVE STRESS; HUMAN OBESITY; EXERCISE; MUSCLE; EVOLUTION; RESPONSES;
   ORIGINS
AB Factors affecting contribution of spontaneous physical activity (SPA; activity associated with everyday tasks) to energy balance of humans are not well understood, as it is not clear whether low activity is related to dietary habits, precedes obesity or is a result of thereof. In particular, human studies on SPA and basal metabolic rates (BMR, accounting for > 50% of human energy budget) and their associations with diet composition, metabolic thrift and obesity are equivocal. To clarify these ambiguities we used a unique animal model D mice selected for divergent BMR rates (the H-BMR and L-BMR line type) presenting a 50% between-line type difference in the primary selected trait. Males of each line type were divided into three groups and fed either a high fat, high carb or a control diet. They then spent 4 months in individual cages under conditions emulating human "sedentary lifestyle", with SPA followed every month and measurements of metabolic risk indicators (body fat mass %, blood lipid profile, fasting blood glucose levels and oxidative damage in the livers, kidneys and hearts) taken at the end of study. Mice with genetically determined high BMR assimilated more energy and had higher SPA irrespective of type of diet. H-BMR individuals were characterized by lower dry body fat mass %, better lipid profile and lower fasting blood glucose levels, but higher oxidative damage in the livers and hearts. Genetically determined high BMR may be a protective factor against diet-induced obesity and most of the metabolic syndrome indicators. Elevated spontaneous activity is correlated with high BMR, and constitutes an important factor affecting individual capability to sustain energy balance even under energy dense diets.
C1 [Sadowska, Julita; Gebczynski, Andrzej K.; Konarzewski, Marek] Univ Bialystok, Inst Biol, Bialystok, Poland.
C3 University of Bialystok
RP Sadowska, J (corresponding author), Univ Bialystok, Inst Biol, Bialystok, Poland.
EM julita.sadowska@uwb.edu.pl
RI Konarzewski, Marek/AAR-9952-2020
OI Konarzewski, Marek/0000-0001-7428-6521; Gebczynski,
   Andrzej/0000-0003-1711-2175; Sadowska, Julita/0000-0003-1457-5254
FU National Science Centre of Poland [2011/01/N/NZ8/02009]; Foundation for
   Polish Science (FNP) START stipend
FX This study was funded by the National Science Centre of Poland (grant
   no. 2011/01/N/NZ8/02009) grant awarded to JS.JS is a recipient of the
   Foundation for Polish Science (FNP) START stipend.This study was funded
   by the National Science Centre of Poland (grant no.
   2011/01/N/NZ8/02009). Special thanks to M. Lewoc, S. Plonowski and B.
   Lewonczuk for help with animal maintenance. We are grateful to Max Plank
   Institute for Ornithology in Radolfzell Germany for the calorimetry
   equipment. JS is supported by the Foundation for Polish Science (FNP).
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   [No title captured]
NR 58
TC 20
Z9 20
U1 0
U2 9
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD FEB 24
PY 2017
VL 12
IS 2
AR e0172892
DI 10.1371/journal.pone.0172892
PG 15
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA EL5VB
UT WOS:000394688200163
PM 28235091
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Zhou, YJ
   Wei, FF
   Fan, Y
AF Zhou, Yongjing
   Wei, Feifei
   Fan, Yu
TI High serum uric acid and risk of nonalcoholic fatty liver disease: A
   systematic review and meta-analysis
SO CLINICAL BIOCHEMISTRY
LA English
DT Review
DE Serum uric acid; Nonalcoholic fatty liver disease; Meta-analysis
ID INSULIN-RESISTANCE; METABOLIC SYNDROME; OXIDATIVE STRESS; HEPATIC
   STEATOSIS; HYPERURICEMIA; PROGRESSION; EPIDEMIOLOGY; ASSOCIATION;
   PREDICTOR; HEALTH
AB Objectives: Emerging evidence connects serum uric acid (SUA) levels to nonalcoholic fatty liver disease (NAFLD). The objective of this study was to systematically evaluate the association between SUA levels and risk of NAFLD by conducting a meta-analysis of available observational studies.
   Design and methods: We searched for relevant studies in PubMed, Embase, China National Knowledge Infrastructure, and Wanfang databases until October 2014. All observational studies that evaluated SUA levels and NAFLD risks were included. Pooled adjusted odds ratio (OR) and corresponding 95% confidence intervals (Cl) were calculated comparing the highest to lowest SUA category.
   Results: Four cross-sectional studies, two prospective studies, and three retrospective studies involving 55,573 participants were identified. In overall risk estimates, the pooled OR of NAFLD occurrence was 1.92 (95% Cl: 1.59-2.31) comparing the highest to lowest SUA levels in a random effect model. Subgroup analysis showed that high SUA levels increased the risk of NAFLD in cross-sectional studies (OR: 2.18; 95% Cl: 1.58-3.03), retrospective studies (OR 1.82; 95% Cl: 1A3-2.33), and prospective studies (OR 1.43; 95% Cl: 1.20-1.71). The risk of NAFLD seemed more pronounced among women (OR 1.85; 95% CI: 1.43-2.38) than among men (OR 1.56; 95% CI: 1.30-1.86).
   Conclusion: This meta-analysis suggests that increased SUA level is associated with an exacerbated risk of NAFLD. This increased risk is probably independent of conventional NAFLD risk factors. (C) 2015 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
C1 [Zhou, Yongjing; Wei, Feifei; Fan, Yu] Jiangsu Univ, Affiliated Peoples Hosp, Inst Mol Biol & Translat Med, 8 Dianli Rd, Zhenjiang 212002, Jiangsu, Peoples R China.
C3 Jiangsu University
RP Fan, Y (corresponding author), Jiangsu Univ, Affiliated Peoples Hosp, Inst Mol Biol & Translat Med, 8 Dianli Rd, Zhenjiang 212002, Jiangsu, Peoples R China.
EM jszjfanyu@163.com
RI WEI, FEIFEI/C-7985-2017
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NR 50
TC 64
Z9 67
U1 0
U2 32
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0009-9120
EI 1873-2933
J9 CLIN BIOCHEM
JI Clin. Biochem.
PD MAY
PY 2016
VL 49
IS 7-8
BP 636
EP 642
DI 10.1016/j.clinbiochem.2015.12.010
PG 7
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA DL1TO
UT WOS:000375415500019
PM 26738417
DA 2025-06-11
ER

PT J
AU Merdzo, I
   Rutkai, I
   Tokes, T
   Sure, VNLR
   Katakam, PVG
   Busija, DW
AF Merdzo, Ivan
   Rutkai, Ibolya
   Tokes, Tunde
   Sure, Venkata N. L. R.
   Katakam, Prasad V. G.
   Busija, David W.
TI The mitochondrial function of the cerebral vasculature in
   insulin-resistant Zucker obese rats
SO AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
LA English
DT Article
DE middle cerebral arteries; insulin resistance; mitochondria;
   mitochondrial respiration; reactive oxygen species; cerebral vessels;
   cerebral microvessels
ID NITRIC-OXIDE SYNTHASE; HUMAN SKELETAL-MUSCLE; METABOLIC SYNDROME;
   OXIDATIVE STRESS; SMOOTH-MUSCLE; SARCOPLASMIC-RETICULUM; SUPEROXIDE
   GENERATION; CA2+ SPARKS; ARTERIES; DYSFUNCTION
AB Little is known about mitochondrial functioning in the cerebral vasculature during insulin resistance (IR). We examined mitochondrial respiration in isolated cerebral arteries of male Zucker obese (ZO) rats and phenotypically normal Zucker lean (ZL) rats using the Seahorse XFe24 analyzer. We investigated mitochondrial morphology in cerebral blood vessels as well as mitochondrial and nonmitochondrial protein expression levels in cerebral arteries and microvessels. We also measured reactive oxygen species (ROS) levels in cerebral microvessels. Under basal conditions, the mitochondrial respiration components (nonmitochondrial respiration, basal respiration, ATP production, proton leak, and spare respiratory capacity) showed similar levels among the ZL and ZO groups with the exception of maximal respiration, which was higher in the ZO group. We examined the role of nitric oxide by measuring mitochondrial respiration following inhibition of nitric oxide synthase with N-omega-nitro-L-arginine methyl ester (L-NAME) and mitochondrial activation after administration of diazoxide (DZ). Both ZL and ZO groups showed similar responses to these stimuli with minor variations. L-NAME significantly increased the proton leak, and DZ decreased nonmitochondrial respiration in the ZL group. Other components were not affected. Mitochondrial morphology and distribution within vascular smooth muscle and endothelium as well as mitochondrial protein levels were similar in the arteries and microvessels of both groups. Endothelial nitric oxide synthase (eNOS) and ROS levels were increased in cerebral microvessels of the ZO. Our study suggests that mitochondrial function is not significantly altered in the cerebral vasculature of young ZO rats, but increased ROS production might be due to increased eNOS in the cerebral microcirculation during IR.
C1 [Merdzo, Ivan; Rutkai, Ibolya; Tokes, Tunde; Sure, Venkata N. L. R.; Katakam, Prasad V. G.; Busija, David W.] Tulane Univ, Sch Med, Dept Pharmacol, 1430 Tulane Ave,MC 8683, New Orleans, LA 70112 USA.
C3 Tulane University
RP Merdzo, I (corresponding author), Tulane Univ, Sch Med, Dept Pharmacol, 1430 Tulane Ave,MC 8683, New Orleans, LA 70112 USA.
EM imerdzo@tulane.edu
RI Sure, Venkata/Y-1488-2019; K, P/AAL-6310-2021
OI Sure, Venkata Naga Lakshmi Ramarao/0000-0002-3657-962X; Katakam,
   Prasad/0000-0002-4708-9140
FU National Institutes of Health [HL-077731, HL093554]; Louisiana Board of
   Regents Support Fund-Research Competitiveness Subprogram [LEQSF
   (2014-17)-RD-A-11]; American Heart Association National Center NRCP
   Scientist Development Grant [14SDG20490359]; American Heart Association
   [15POST23040005]; Louisiana Board of Regents Endowed Chairs; American
   Heart Association (AHA) [15POST23040005] Funding Source: American Heart
   Association (AHA)
FX This work was supported by National Institutes of Health grants
   (HL-077731 and HL093554 to D. Busija), Louisiana Board of Regents
   Support Fund-Research Competitiveness Subprogram [LEQSF
   (2014-17)-RD-A-11 to P. Katakam], American Heart Association National
   Center NRCP Scientist Development Grant (14SDG20490359 to P. Katakam),
   and American Heart Association Post-Doctoral Fellowship Grant
   (15POST23040005 to I. Rutkai). This research was supported in whole or
   in part by the Louisiana Board of Regents Endowed Chairs for Eminent
   Scholars program.
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NR 49
TC 17
Z9 19
U1 0
U2 9
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0363-6135
EI 1522-1539
J9 AM J PHYSIOL-HEART C
JI Am. J. Physiol.-Heart Circul. Physiol.
PD APR 1
PY 2016
VL 310
IS 7
BP H830
EP H838
DI 10.1152/ajpheart.00964.2015
PG 9
WC Cardiac & Cardiovascular Systems; Physiology; Peripheral Vascular
   Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Physiology
GA DI1RC
UT WOS:000373272200005
PM 26873973
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Saavedra, P
   Girona, J
   Bosquet, A
   Guaita, S
   Canela, N
   Aragonès, G
   Heras, M
   Masana, L
AF Saavedra, Paula
   Girona, Josefa
   Bosquet, Alba
   Guaita, Sandra
   Canela, Nuria
   Aragones, Gemma
   Heras, Mercedes
   Masana, Lluis
TI New insights into circulating FABP4: Interaction with cytokeratin 1 on
   endothelial cell membranes
SO BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
LA English
DT Article
DE FABP4; Endothelial cell; Cell surface receptor; Cytokeratin 1; FABP4
   inhibition
ID ACID-BINDING PROTEIN; PLASMINOGEN-ACTIVATOR RECEPTOR; METABOLIC
   SYNDROME; PLASMA FATTY-ACID-BINDING-PROTEIN-4; CAROTID ATHEROSCLEROSIS;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; OBESITY; BIOMARKER; MICE
AB Fatty acid-binding protein 4 (FABP4) is an adipose tissue-secreted adipokine that is involved in the regulation of energetic metabolism and inflammation. Increased levels of circulating FABP4 have been detected in individuals with cardiovascular risk factors. Recent studies have demonstrated that FABP4 has a direct effect on peripheral tissues, specifically promoting vascular dysfunction; however, its mechanism of action is unknown. The objective of this work was to assess the specific interactions between exogenous FABP4 and the plasma membranes of endothelial cells. Immunofluorescence assays showed that exogenous FABP4 localized along the plasma membranes of human umbilical vein endothelial cells (HUVECs), interacting specifically with plasma membrane proteins. Anti-FABP4 immunoblotting revealed two covalent protein complexes containing FABP4 and its putative receptor; these complexes were approximately 108 kDa and 77 kDa in size. Proteomics and mass spectrometry experiments revealed that cytokeratin 1 (CK1) was the FABP4-binding protein. An anti-CK1 immunoblot confirmed the presence of CK1. FABP4-CK1 complexes were also detected in HAECs, HCASMCs, HepG2 cells and THP-1 cells. Pharmacological FABP4 inhibition by BMS309403 results in a slight decrease in the formation of these complexes, indicating that fatty acids may play a role in FABP4 functionality. In addition, we demonstrated that exogenous FABP4 crosses the plasma membrane to enter the cytoplasm and nucleus in HUVECs. These findings indicate that exogenous FABP4 interacts with plasma membrane proteins, specifically CK1. These data contribute to our current knowledge regarding the mechanism of action of circulating FABP4. (C) 2015 Published by Elsevier B.V.
C1 [Saavedra, Paula; Girona, Josefa; Bosquet, Alba; Guaita, Sandra; Aragones, Gemma; Heras, Mercedes; Masana, Lluis] Univ Rovira & Virgili, Res Unit Lipids & Atherosclerosis, St Joan Univ Hosp, IISPV,CIBERDEM, E-43201 Reus, Spain.
   [Canela, Nuria] Univ Rovira & Virgili, Ctr Omics Sci, E-43201 Reus, Spain.
C3 Universitat Rovira i Virgili; Institut d'Investigacio Sanitaria Pere
   Virgili (IISPV); CIBER - Centro de Investigacion Biomedica en Red;
   CIBERDEM; Universitat Rovira i Virgili
RP Masana, L (corresponding author), Fac Med & Ciencies Salut Reus, Lipids & Atherosclerosis Res Unit, C St Llorenc 21, Reus 43201, Tarragona, Spain.
EM luis.masana@urv.cat
RI MASANA, LUIS/M-7002-2019; GUAITA-ESTERUELAS, SANDRA/D-7292-2019;
   Aragones, Gemma/A-9693-2013; Canela, Nuria/I-5401-2015; Girona,
   Josefa/U-3489-2018
OI Aragones, Gemma/0000-0002-1924-9231; Masana, Luis/0000-0002-0789-4954;
   Canela, Nuria/0000-0003-0261-2396; Saavedra, Paula/0000-0002-9907-475X;
   Heras, Mercedes/0000-0002-5285-154X; Girona, Josefa/0000-0002-6267-8779
FU ISCIII, Madrid, Spain [PI 11/02216, FI12/00421]; CIBER in Diabetes and
   Associated Metabolic Disorders (ISCIII, Ministerio de Ciencia e
   Innovacion), Spain; Rovira I Virgili University (Marti-Franques Research
   Grant) [2012BPURV-60]
FX This work was supported by grants from the ISCIII, Madrid, Spain (PI
   11/02216) and from the CIBER in Diabetes and Associated Metabolic
   Disorders (ISCIII, Ministerio de Ciencia e Innovacion), Spain. P.S. was
   supported by a doctoral fellowship from the Rovira I Virgili University
   (Marti-Franques Research Grant, 2012BPURV-60) and A.B. was supported by
   a doctoral fellowship from the ISCIII, Madrid, Spain (FI12/00421).
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NR 51
TC 27
Z9 27
U1 0
U2 21
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0167-4889
EI 0006-3002
J9 BBA-MOL CELL RES
JI Biochim. Biophys. Acta-Mol. Cell Res.
PD NOV
PY 2015
VL 1853
IS 11
BP 2966
EP 2974
DI 10.1016/j.bbamcr.2015.09.002
PN A
PG 9
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA CT8LV
UT WOS:000363069000012
PM 26343611
OA Bronze
DA 2025-06-11
ER

PT J
AU Swary, JH
   Stratman, EJ
AF Swary, Jillian H.
   Stratman, Erik J.
TI Identifying Performance Gaps in Comorbidity and Risk Factor Screening,
   Prevention, and Counseling Behaviors of Providers Caring for Children
   with Psoriasis
SO PEDIATRIC DERMATOLOGY
LA English
DT Article
ID PEDIATRIC PSORIASIS; CARDIOVASCULAR RISK; METABOLIC SYNDROME; SEVERITY;
   ASSOCIATION; POPULATION; PREVALENCE; AGE
AB Background/ObjectivesComorbidities and risk factors are associated with pediatric psoriasis. It is unknown whether pediatricians and dermatologists ask about, record, or counsel on pediatric psoriasis risk factors and comorbidities. The aim of our study was to assess the rate at which pediatricians and dermatologists inquire about, counsel on, and document pediatric psoriasis risk factors and comorbidities in a stable population.
   MethodsThis was a retrospective chart review from 2011 to 2013 in a large, rural multidisciplinary clinic, the Marshfield Epidemiologic Study Area. Participants were children ages 18 years and younger with plaque psoriasis. Rates of counseling and screening for pediatric psoriasis risk factors and comorbidities by pediatricians and dermatologists were determined.
   ResultsThirty patients qualified for the study. Data were collected on body mass index (BMI) and tobacco exposure. Caregiver counseling rates on these factors were low; 66.7% and 60% did not receive counseling on BMI reduction or family member smoking cessation, respectively. Counseling on stress as a risk factor was performed at only one patient's dermatology visit (3.3%). Lipid panels were collected for 40% of patients and fasting glucose levels for 33.3% since the date of first psoriasis diagnosis. Blood pressure was collected for all patients. Only 13.3% of patients were counseled on the psoriasis comorbidity hyperlipidemia, 10% on hypertension, and 3.3% on diabetes mellitus.
   ConclusionsDermatologists and pediatricians have a low rate of counseling, documenting, and screening for pediatric psoriasis risk factors and comorbidities, suggesting that psoriasis comorbidity education is an aspect of the patient visit that may need improvement. Pediatric psoriasis counseling and screening guidelines are needed.
C1 [Swary, Jillian H.; Stratman, Erik J.] Marshfield Clin Fdn Med Res & Educ, Dept Dermatol, Marshfield, WI 54449 USA.
C3 Marshfield Clinic
RP Stratman, EJ (corresponding author), Marshfield Clin Fdn Med Res & Educ, Dept Dermatol 4K5, 1000 North Oak Ave, Marshfield, WI 54449 USA.
EM stratman.erik@marshfieldclinic.org
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NR 18
TC 4
Z9 4
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0736-8046
EI 1525-1470
J9 PEDIATR DERMATOL
JI Pediatr. Dermatol.
PD NOV-DEC
PY 2015
VL 32
IS 6
BP 813
EP 818
DI 10.1111/pde.12669
PG 6
WC Dermatology; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Pediatrics
GA CX2KQ
UT WOS:000365526000040
PM 26337861
DA 2025-06-11
ER

PT J
AU Vieira, RAL
   de Freitas, RN
   Volp, ACP
AF Lima Vieira, Renata Adrielle
   de Freitas, Renata Naseimento
   Pinheiro Volp, Ana Carolina
TI Adhesion molecules and chemokines: relation to anthropometric, body
   composition, biochemical and dietary variables
SO NUTRICION HOSPITALARIA
LA English
DT Review
DE Cell adhesion molecules; Inflammation; Body composition; Anthropometry;
   Dietary habits
ID MONOCYTE CHEMOATTRACTANT PROTEIN-1; CARDIOVASCULAR-DISEASE RISK;
   LOW-CARBOHYDRATE DIET; E-SELECTIN; OXIDATIVE STRESS; P-SELECTIN;
   METABOLIC SYNDROME; WEIGHT-LOSS; INFLAMMATORY BIOMARKERS; CIRCULATING
   LEVELS
AB Introduction: Among the inflammatory mediators involved in the pathogenesis of obesity, the cell adhesion molecules P-selectin, E-selectin, VCAM-1, ICAM-1 and the chemokine MCP-1 stand out. They play a crucial role in adherence of cells to endothelial surfaces, in the integrity of the vascular wall and can be modulated by body composition and dietary pattern.
   Objectives: To describe and discuss the relation of these cell adhesion molecules and chemokines to anthropometric, body composition, dietary and biochemical markers.
   Methods: Papers were located using scientific databases by topic searches with no restriction on year of publication.
   Results: All molecules were associated positively with anthropometric markers, but controversial results were found for ICAM-1 and VCAM-1. Not only obesity, but visceral fat is more strongly correlated with E-selectin and MCP-1 levels. Weight loss influences the reduction in the levels of these molecules, except VCAM-1. The distribution of macronutrients, excessive consumption of saturated and trans fat and a Western dietary pattern are associated with increased levels. The opposite could be observed with supplementation of w-3 fatty acid, healthy dietary pattern, high calcium diet and high dairy intake. Regarding the biochemical parameters, they have inverse relation to HDL-C and positive relation to total cholesterol, triglycerides, blood glucose, fasting insulin and insulin resistance.
   Conclusion: Normal anthropometric indicators, body composition, biochemical parameters and eating pattern positively modulate the subclinical inflammation that results from obesity by reducing the cell adhesion molecules and chemokines.
C1 [Lima Vieira, Renata Adrielle; de Freitas, Renata Naseimento; Pinheiro Volp, Ana Carolina] Univ Fed Ouro Preto, Ouro Preto, MG, Brazil.
C3 Universidade Federal de Ouro Preto
RP Volp, ACP (corresponding author), Univ Fed Ouro Preto, Nutr Sch, Dept Clin & Social Nutr, Campus Univ,Morro do Cruzeiro S-N, BR-35400000 Ouro Preto, MG, Brazil.
EM anavolp@gmail.com
FU Federal University of Ouro Preto
FX We thank the Federal University of Ouro Preto by support funding which
   allowed the translation of this article.
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NR 95
TC 23
Z9 24
U1 0
U2 9
PU ARAN EDICIONES, S L
PI MADRID
PA C/ CASTELLO, 128, 1O, MADRID, 28006, SPAIN
SN 0212-1611
EI 1699-5198
J9 NUTR HOSP
JI Nutr. Hosp.
PD AUG
PY 2014
VL 30
IS 2
BP 223
EP 236
DI 10.3305/nh.2014.30.2.7416
PG 14
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA AP7QW
UT WOS:000342272800001
PM 25208773
DA 2025-06-11
ER

PT J
AU Leibowitz, A
   Faltin, Z
   Perl, A
   Eshdat, Y
   Hagay, Y
   Peleg, E
   Grossman, E
AF Leibowitz, A.
   Faltin, Z.
   Perl, A.
   Eshdat, Y.
   Hagay, Y.
   Peleg, E.
   Grossman, E.
TI Red grape berry-cultured cells reduce blood pressure in rats with
   metabolic-like syndrome
SO EUROPEAN JOURNAL OF NUTRITION
LA English
DT Article
DE Rats; Metabolic syndrome; Blood pressure; Red grape-cultured cell;
   Endothelin-1; Endothelial NO synthase
ID NITRIC-OXIDE SYNTHASE; SPONTANEOUSLY HYPERTENSIVE-RATS; FRUCTOSE-FED
   RATS; RESVERATROL PREVENTS; OXIDATIVE STRESS; CARDIOVASCULAR HEALTH;
   DIETARY POLYPHENOLS; INSULIN-RESISTANCE; ADIPONECTIN LEVELS;
   ENDOTHELIAL-CELLS
AB Cumulative evidence suggests that moderate red wine consumption protects the cardiovascular system. The effect of cultured cells derived from red grape berry (RGC) on blood pressure (BP) has not been investigated. We therefore studied the antihypertensive effects of oral consumption of RGC in experimental rat model of metabolic-like syndrome and assessed its effect on human umbilical vein endothelial cells (HUVECs).
   Forty male Sprague-Dawley rats were fed for 5 weeks with either a high fructose diet (HFD) (n = 10) or HFD supplemented, during the last 2 weeks, with different doses (200, 400 and 800 mg/kg/day) of RGC suspended in their food (n = 30). BP, plasma triglycerides, insulin and adiponectin levels were measured at the beginning and after 3 and 5 weeks of diet. RGC effect on vasodilatation was evaluated by its ability to affect endothelin-1 (ET-1) production and endothelial nitric oxide synthase (eNOS) expression in HUVECs.
   BP, plasma triglycerides, insulin and adiponectin increased significantly in rats fed with a HFD. The increase in BP, plasma triglycerides and insulin was attenuated by RGC supplementation. Incubation of HUVECs with RGC demonstrated a concentration-dependent inhibition of ET-1 secretion and increase in the level of eNOS, signaling a positive effect of RGC on vasodilatation.
   In rats with metabolic-like syndrome, RGC decreased BP and improved metabolic parameters. These beneficial effects may be mediated by the cell constituents, highly rich with polyphenols and resveratrol, reside in their natural state.
C1 [Leibowitz, A.; Peleg, E.; Grossman, E.] Chaim Sheba Med Ctr, IL-52621 Tel Hashomer, Israel.
   [Leibowitz, A.; Peleg, E.; Grossman, E.] Chaim Sheba Med Ctr, Hypertens Unit, IL-52621 Tel Hashomer, Israel.
   [Leibowitz, A.; Peleg, E.; Grossman, E.] Tel Aviv Univ, Sackler Fac Med, IL-69978 Tel Aviv, Israel.
   [Faltin, Z.; Perl, A.; Eshdat, Y.] Agr Res Org, Volcani Ctr, Inst Plant Sci, IL-50250 Bet Dagan, Israel.
   [Hagay, Y.] Fruitura Biosci, Rehovot, Israel.
C3 Chaim Sheba Medical Center; Chaim Sheba Medical Center; Tel Aviv
   University; Sackler Faculty of Medicine; VOLCANI INSTITUTE OF
   AGRICULTURAL RESEARCH
RP Leibowitz, A (corresponding author), Chaim Sheba Med Ctr, IL-52621 Tel Hashomer, Israel.
EM Avshalom.Leibowitz@sheba.health.gov.il
OI Grossman, Ehud/0000-0001-8353-0661
FU Fruitura Bioscience Ltd. Rehovot, Israel
FX Dr. Avshhalom Leibowitz, Dr. Edna Peleg and Dr. Ehud Grossman received a
   research grant from Fruitura (formly Hi-Nutra) Bioscience Ltd. Rehovot,
   Israel.
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NR 39
TC 16
Z9 18
U1 0
U2 19
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1436-6207
EI 1436-6215
J9 EUR J NUTR
JI Eur. J. Nutr.
PD APR
PY 2014
VL 53
IS 3
BP 973
EP 980
DI 10.1007/s00394-013-0601-z
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA AE5UI
UT WOS:000334054400027
PM 24158651
DA 2025-06-11
ER

PT J
AU Rahman, ST
   Merchant, N
   Haque, T
   Wahi, J
   Bhaheetharan, S
   Ferdinand, KC
   Khan, BV
AF Rahman, Syed T.
   Merchant, Nadya
   Haque, Tahir
   Wahi, Jessica
   Bhaheetharan, Sujan
   Ferdinand, Keith C.
   Khan, Bobby V.
TI The Impact of Lipoic Acid on Endothelial Function and Proteinuria in
   Quinapril-Treated Diabetic Patients With Stage I Hypertension: Results
   From the QUALITY Study
SO JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS
LA English
DT Article
DE albuminuria; obesity; inflammation; lipoic acid; renin-angiotensin
   system
ID CONVERTING-ENZYME-INHIBITION; METABOLIC SYNDROME; THIOCTIC ACID;
   CARDIOVASCULAR-DISEASE; RECEPTOR ANTAGONIST; INSULIN-RESISTANCE;
   OXIDATIVE STRESS; GLUCOSE-DISPOSAL; ACE-INHIBITORS; RISK-FACTORS
AB Background: We sought to determine whether a combination of angiotensin-converting enzyme inhibitors (ACEIs) and the nutraceutical alpha-lipoic acid (ALA) regulates blood pressure, endothelial function, and proteinuria in diabetic patients with Stage I hypertension. Methods: A total of 40 diabetic patients with Stage I hypertension were treated in a crossover double-blinded manner. Patients were administered quinapril ([QUI] 40 mg/d) for 8 weeks or QUI + ALA (600 mg/d) for 8 weeks. Measurements included blood pressure, 24-hour collection of urinary albumin, and endothelial-dependent flow-mediated dilation (FMD). Results: There was a change of metabolic parameters in both study groups after 8 weeks of therapy. In comparison to baseline, the 24-hour urinary albumin significantly decreased by 30% in the QUI group (P = .018, time comparison) and 53% in QUI + ALA group (P < .005, time and group comparison). Also, when compared with baseline, FMD significantly increased by 58% in QUI group (P < .005, time comparison) and by 116% in QUI + ALA group (P < .005, time and group comparison). Systolic and diastolic blood pressure reduced significantly by 10% with QUI treatment. There was no further blood pressure reduction when patients were administered both QUI and ALA. Conclusions: In diabetic patients with hypertension, QUI reduces blood pressure, proteinuria, and improves endothelial function. Moreover, this effect is strongly potentiated with a combination of QUI and ALA. These results may attenuate the progression of vascular pathophysiology seen in patients with a combination of diabetes and hypertension.
C1 [Haque, Tahir; Bhaheetharan, Sujan; Khan, Bobby V.] Atlanta Vasc Res Fdn, Atlanta, GA 30084 USA.
   [Rahman, Syed T.; Merchant, Nadya; Haque, Tahir; Wahi, Jessica; Bhaheetharan, Sujan; Ferdinand, Keith C.; Khan, Bobby V.] Emory Univ, Sch Med, Div Cardiol, Atlanta, GA 30322 USA.
C3 Emory University
RP Khan, BV (corresponding author), Atlanta Vasc Res Fdn, 3562 Habersham Northlake, Atlanta, GA 30084 USA.
EM bobby.khan@atlresearch.org
OI Wahi, Jessica/0000-0003-2379-1039
FU InVasc Therapeutics
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: InVasc
   Therapeutics sponsored this study.
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NR 49
TC 24
Z9 25
U1 0
U2 0
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1074-2484
J9 J CARDIOVASC PHARM T
JI J. Cardiovasc. Pharmacol. Ther.
PD JUN
PY 2012
VL 17
IS 2
BP 139
EP 145
DI 10.1177/1074248411413282
PG 7
WC Cardiac & Cardiovascular Systems; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Pharmacology & Pharmacy
GA 939SF
UT WOS:000303833800002
PM 21750253
DA 2025-06-11
ER

PT J
AU Hong, Q
   Qi, K
   Feng, Z
   Huang, ZY
   Cui, SY
   Wang, LY
   Fu, B
   Ding, R
   Yang, JR
   Chen, XM
   Wu, D
AF Hong Quan
   Qi Ka
   Feng Zhe
   Huang Zhiyong
   Cui Shaoyuan
   Wang Liyuan
   Fu Bo
   Ding Rui
   Yang Jurong
   Chen Xiangmei
   Wu Di
TI Hyperuricemia induces endothelial dysfunction via mitochondrial
   Na<SUP>+</SUP>/Ca<SUP>2+</SUP> exchanger-mediated mitochondrial calcium
   overload
SO CELL CALCIUM
LA English
DT Article
DE Uric acid; Calcium channels; NCXmito; Oxidative response; Endothelial
   dysfunction
ID SERUM URIC-ACID; TYPE-2 DIABETES-MELLITUS; NITRIC-OXIDE PRODUCTION;
   OXIDATIVE STRESS; IN-VITRO; INTRACELLULAR CALCIUM; HYPERTENSIVE
   PATIENTS; MOLECULAR-MECHANISMS; HEART-MITOCHONDRIA; METABOLIC SYNDROME
AB Background: Uric acid (UA) has proven to be a causal agent in endothelial dysfunction in which ROS production plays an important role. Calcium overload in mitochondria can promote the mitochondrial production of ROS. We hypothesize that calcium transduction in mitochondria contributes to UA-induced endothelial dysfunction.
   Methods and results: We first demonstrated that high concentrations of UA cause endothelial dysfunction, marked by a reduction in eNOS protein expression and NO release in vitro. We further found that a high concentration of UA increased levels of [Ca2+](mito), total intracellular ROS, H2O2, and mitochondrial O-2(center dot-), and Delta psi(mito) but not the [Ca2+](cyt) level. When the mitochondrial calcium channels NCXmito and MCU were blocked by CGP-37157 and Ru360, respectively, the UA-induced increases in the levels of [Ca2+](mito) and total intracellular ROS were significantly reduced. Mitochondrial levels of O-2(center dot-) and Delta psi(mito) were reduced by inhibition of NCXmito but not of MCU. Moreover, inhibition of NCXmito, but not of MCU, blocked the UA-induced reductions in eNOS protein expression and NO release.
   Conclusions: The increased generation of mitochondrial O-2(center dot-) induced by a high concentration of UA is triggered by mitochondrial calcium overload and ultimately leads to endothelial dysfunction. In this process, the activation of NCXmito is the major cause of the influx of calcium into mitochondria. Our results provide a new pathophysiological mechanism for UA-induced endothelial dysfunction and may offer a new therapeutic target for clinicians. (C) 2012 Elsevier Ltd. All rights reserved.
C1 [Hong Quan; Qi Ka; Feng Zhe; Huang Zhiyong; Cui Shaoyuan; Wang Liyuan; Fu Bo; Ding Rui; Yang Jurong; Chen Xiangmei; Wu Di] Chinese Peoples Liberat Army Gen Hosp, Dept Nephrol, State Key Lab Kidney Dis, Beijing 100853, Peoples R China.
   [Qi Ka] 281st Hosp PLA, Dept Nephrol, Beidaihe 066105, Peoples R China.
   [Yang Jurong] Third Mil Med Univ, Inst Surg Res, Daping Hosp, Dept Nephrol, Chongqing 400042, Peoples R China.
C3 Chinese People's Liberation Army General Hospital; Army Medical
   University
RP Wu, D (corresponding author), Chinese Peoples Liberat Army Gen Hosp, Dept Nephrol, State Key Lab Kidney Dis, 2011DAV00088, Beijing 100853, Peoples R China.
EM wudi@301hospital.com.cn
RI Yang, Jurong/AGO-6020-2022; Ding, Rui/AAL-7714-2021
FU Chinese National Natural Sciences Foundation [81102673, 31170810]
FX This work was supported by Chinese National Natural Sciences Foundation
   (Nos. 81102673 and 31170810). We thank Dr. Shujing Zhao (General
   Hospital of Guangzhou Military Command,; Guangzhou, China) gift PEG-SOD,
   and Kristen Choffe (Royal Ontario Museum, Toronto, Ontario, Canada)
   offer English language support.
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NR 61
TC 93
Z9 109
U1 1
U2 28
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0143-4160
J9 CELL CALCIUM
JI Cell Calcium
PD MAY
PY 2012
VL 51
IS 5
BP 402
EP 410
DI 10.1016/j.ceca.2012.01.003
PG 9
WC Cell Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Physiology
GA 932KY
UT WOS:000303291200004
PM 22361139
DA 2025-06-11
ER

PT J
AU Terao, M
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   Murota, Hiroyuki
   Kimura, Akihiro
   Kato, Arisa
   Ishikawa, Akiko
   Igawa, Ken
   Miyoshi, Eiji
   Katayama, Ichiro
TI 11β-Hydroxysteroid Dehydrogenase-1 Is a Novel Regulator of Skin
   Homeostasis and a Candidate Target for Promoting Tissue Repair
SO PLOS ONE
LA English
DT Article
ID SUBCUTANEOUS ADIPOSE-TISSUE; GLUCOCORTICOID-RECEPTOR; METABOLIC
   SYNDROME; TYPE-1; MICE; 11-BETA-HSD1; OBESE; DIFFERENTIATION;
   INHIBITION; STRESS
AB 11 beta-hydroxysteroid dehydrogenase 1 (11 beta-HSD1) catalyzes the interconversion of cortisone and cortisol within the endoplasmic reticulum. 11 beta-HSD1 is expressed widely, most notably in the liver, adipose tissue, and central nervous system. It has been studied intensely over the last 10 years because its activity is reported to be increased in visceral adipose tissue of obese people. Epidermal keratinocytes and dermal fibroblasts also express 11 beta-HSD1. However, the function of the enzymatic activity 11 beta-HSD1 in skin is not known. We found that 11 beta-HSD1 was expressed in human and murine epidermis, and this expression increased as keratinocytes differentiate. The expression of 11 beta-HSD1 by normal human epidermal keratinocytes (NHEKs) was increased by starvation or calcium-induced differentiation in vitro. A selective inhibitor of 11 beta-HSD1 promoted proliferation of NHEKs and normal human dermal fibroblasts, but did not alter the differentiation of NHEKs. Topical application of selective 11 beta-HSD1 inhibitor to the dorsal skin of hairless mice caused proliferation of keratinocytes. Taken together, these data suggest that 11 beta-HSD1 is involved in tissue remodeling of the skin. This hypothesis was further supported by the observation that topical application of the selective 11 beta-HSD1 inhibitor enhanced cutaneous wound healing in C57BL/6 mice and ob/ob mice. Collectively, we conclude that 11 beta-HSD1 is negatively regulating the proliferation of keratinocytes and fibroblasts, and cutaneous wound healing. Hence, 11 beta-HSD1 might maintain skin homeostasis by regulating the proliferation of keratinocytes and dermal fibroblasts. Thus 11 beta-HSD1 is a novel candidate target for the design of skin disease treatments.
C1 [Terao, Mika; Murota, Hiroyuki; Kimura, Akihiro; Kato, Arisa; Ishikawa, Akiko; Igawa, Ken; Katayama, Ichiro] Osaka Univ, Dept Dermatol, Grad Sch Med, Osaka, Japan.
   [Miyoshi, Eiji] Osaka Univ, Dept Mol Biochem & Clin Invest, Osaka, Japan.
C3 The University of Osaka; The University of Osaka
RP Terao, M (corresponding author), Osaka Univ, Dept Dermatol, Grad Sch Med, Osaka, Japan.
EM mterao@derma.med.osaka-u.ac.jp
OI Kimura, Akihiro/0000-0001-5614-8547
FU Japan Society for the Promotion of Science [21591464]; Grants-in-Aid for
   Scientific Research [21591464] Funding Source: KAKEN
FX This work was supported in part by a Grant-in-Aid for Scientific
   Research(C) No. 21591464 from the Japan Society for the Promotion of
   Science. The funders had no role in study design, data collection and
   analysis, decision to publish, or preparation of the manuscript. No
   additional external funding received for this study.
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NR 35
TC 62
Z9 66
U1 0
U2 9
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD SEP 20
PY 2011
VL 6
IS 9
AR e25039
DI 10.1371/journal.pone.0025039
PG 11
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 825GY
UT WOS:000295260400039
PM 21949844
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Salbaum, JM
   Kruger, C
   Zhang, X
   Delahaye, NA
   Pavlinkova, G
   Burk, DH
   Kappen, C
AF Salbaum, J. M.
   Kruger, C.
   Zhang, X.
   Delahaye, N. Arbour
   Pavlinkova, G.
   Burk, D. H.
   Kappen, C.
TI Altered gene expression and spongiotrophoblast differentiation in
   placenta from a mouse model of diabetes in pregnancy
SO DIABETOLOGIA
LA English
DT Article
DE Diabetic placenta; Diabetic pregnancy; Gene expression profiling; Gene
   regulation; Hyperglycaemia; Junctional layer; Maternal diabetes;
   Placental insufficiency; Spongiotrophoblast; Transcription factors
ID FACTOR-KAPPA-B; CONGENITAL-ANOMALIES; TROPHOBLAST LINEAGE; FETAL; MICE;
   EMBRYOPATHY; DEFECTS; PROTEIN; STRESS; OVERT
AB Pregnancies complicated by diabetes have a higher risk of adverse outcomes for mothers and children, including predisposition to disease later in life, e.g. metabolic syndrome and hypertension. We hypothesised that adverse outcomes from diabetic pregnancies may be linked to compromised placental function, and sought to identify cellular and molecular abnormalities in diabetic placenta.
   Using a mouse model of diabetic pregnancy, placental gene expression was assayed at mid-gestation and cellular composition analysed at various stages. Genome-wide expression profiling was validated by quantitative PCR and tissue localisation studies were performed to identify cellular correlates of altered gene expression in diabetic placenta.
   We detected significantly altered gene expression in diabetic placenta for genes expressed in the maternal and those expressed in the embryonic compartments. We also found altered cellular composition of the decidual compartment. In addition, the junctional and labyrinth layers were reduced in diabetic placenta, accompanied by aberrant differentiation of spongiotrophoblast cells.
   Diabetes during pregnancy alters transcriptional profiles in the murine placenta, affecting cells of embryonic and maternal origin, and involving several genes not previously implicated in diabetic pregnancies. The molecular changes and abnormal differentiation of multiple cell types precede impaired growth of junctional zone and labyrinth, and of placenta overall. Regardless of whether these changes represent direct responses to hyperglycaemia or are physiological adaptations, they are likely to play a role in pregnancy complications and outcomes, and to have implications for developmental origins of adult disease.
C1 [Kruger, C.; Zhang, X.; Kappen, C.] Pennington Biomed Res Ctr, Dept Maternal Biol, Baton Rouge, LA 70808 USA.
   [Salbaum, J. M.; Delahaye, N. Arbour] Pennington Biomed Res Ctr, Lab Regulat Gene Express, Baton Rouge, LA 70808 USA.
   [Pavlinkova, G.] Univ Nebraska, Med Ctr, Dept Pediat, Omaha, NE USA.
C3 Louisiana State University System; Louisiana State University;
   Pennington Biomedical Research Center; Louisiana State University
   System; Louisiana State University; Pennington Biomedical Research
   Center; University of Nebraska System; University of Nebraska Medical
   Center
RP Kappen, C (corresponding author), Pennington Biomed Res Ctr, Dept Maternal Biol, 6400 Perkins Rd, Baton Rouge, LA 70808 USA.
EM claudia.kappen@pbrc.edu
RI Burk, David/D-2056-2009; Pavlinkova, Gabriela/G-9304-2014
OI Pavlinkova, Gabriela/0000-0002-5689-6577
FU [RO1-HD34706];  [RO1-HD055528];  [COBRE P20RR021945];  [CNRU
   P30DK072476];  [G20RR024838]
FX We are grateful for expert technical assistance by J. MacGowan, who
   performed the animal work and dissections. This work was funded in part
   through RO1-HD34706 to C. Kappen with a supplement to G. Pavlinkova, and
   through RO1-HD055528 to J. M. Salbaum with a supplement to N. Arbour
   Delahaye, as well as through the Peggy M. Pennington Cole Chair for
   Maternal Biology (C. Kappen). Histological investigations made use of
   the Cell Biology and Bioimaging Core Facility at Pennington, and PCR
   assays were performed in the Genomics Core Facility (both facilities are
   supported through COBRE P20RR021945 and CNRU P30DK072476). The
   Comparative Biology Core Facilities received support through
   G20RR024838.
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NR 48
TC 32
Z9 35
U1 0
U2 7
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0012-186X
EI 1432-0428
J9 DIABETOLOGIA
JI Diabetologia
PD JUL
PY 2011
VL 54
IS 7
BP 1909
EP 1920
DI 10.1007/s00125-011-2132-6
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 774MZ
UT WOS:000291392000038
PM 21491160
OA Bronze, Green Accepted
DA 2025-06-11
ER

PT J
AU Guo, HH
   Ling, WH
   Wang, Q
   Liu, C
   Hu, Y
   Xia, M
AF Guo, Honghui
   Ling, Wenhua
   Wang, Qing
   Liu, Chi
   Hu, Yan
   Xia, Min
TI Cyanidin 3-glucoside protects 3T3-L1 adipocytes against
   H2O2- or TNF-α-induced insulin resistance by
   inhibiting c-Jun NH2-terminal kinase activation
SO BIOCHEMICAL PHARMACOLOGY
LA English
DT Article
DE anthocyanin; cyanidin 3-glucoside; c-Jun NH2-terminal kinase; insulin
   resistance; 3T3-L1 adipocyte
ID SATIVA L. INDICA; OXIDATIVE STRESS; MOLECULAR-MECHANISMS; RECEPTOR
   SUBSTRATE-1; METABOLIC SYNDROME; OBESITY; JNK; ANTHOCYANINS; GLUCOSE;
   ACID
AB Anthocyanins are naturally occurring plant pigments and exhibit an array of pharmacological properties. Our previous study showed that black rice pigment extract rich in anthocyanin prevents and ameliorates high - fructose -induced insulin resistance in rats. In present study, cyanidin 3-glucoside (Cy-3-G), a typical anthocyanin most abundant in black rice was used to examine its protective effect on insulin sensitivity in 3T3-L1 adipocytes exposed to H2O2 (generated by adding glucose oxidase to the medium) or tumor necrosis factor alpha (TNF-alpha). Twelve-hour exposure of 3T3-L1 adipocytes to H2O2 or TNF-alpha resulted in the increase of c-Jun NH2-terminal kinase (JNK) activation and insulin receptor substrate 1 (IRS1) serine 307 phosphorylation, concomitantly with the decrease in insulin-stimulated IRS1 tyrosine phosphorylation and cellular glucose uptake. Blocking JNK expression using RNA interference efficiently prevented the H2O2- or TNF-alpha-induced defects in insulin action. Pretreatment of cells with Cy-3-G reduced the intracellular production of reactive oxygen species, the activation of JNK, and attenuated H2O2- or TNF-alpha-induced insulin resistance in a dose-dependent manner. In parallel, N-acetyl-cysteine, an antioxidant compound, did not exhibit an attenuation of TNF-alpha-induced insulin resistance. Taken together, these results indicated that Cy-3-G exerts a protective role against H2O2- or TNF-alpha-induced insulin resistance in 3T3-L1 adipocytes by inhibiting the JNK signal pathway. (c) 2007 Elsevier Inc. All rights reserved.
C1 [Guo, Honghui; Ling, Wenhua; Wang, Qing; Liu, Chi; Hu, Yan; Xia, Min] Sun Yat Sen Univ, Sch Publ Hlth, Dept Nutr, Guangzhou 510080, Guangdong, Peoples R China.
C3 Sun Yat Sen University
RP Ling, WH (corresponding author), Sun Yat Sen Univ, Sch Publ Hlth, Dept Nutr, No Campus,74 Zhongshan Rd 2, Guangzhou 510080, Guangdong, Peoples R China.
EM lingwh@mail.sysu.edu.cn
RI Guo, Honghui/J-6355-2014
OI Guo, Honghui/0000-0001-7837-0392
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NR 36
TC 99
Z9 109
U1 0
U2 23
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0006-2952
EI 1873-2968
J9 BIOCHEM PHARMACOL
JI Biochem. Pharmacol.
PD MAR 15
PY 2008
VL 75
IS 6
BP 1393
EP 1401
DI 10.1016/j.bcp.2007.11.016
PG 9
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 284EC
UT WOS:000254687800015
PM 18179781
DA 2025-06-11
ER

PT J
AU Puri, P
   Mirshahi, F
   Cheung, O
   Natarajan, R
   Maher, JW
   Kellum, JM
   Sanyal, AJ
AF Puri, Puneet
   Mirshahi, Faridoddin
   Cheung, Onpan
   Natarajan, Ramesh
   Maher, James W.
   Kellum, John M.
   Sanyal, Arun J.
TI Activation and dysregulation of the unfolded protein response in
   nonalcoholic fatty liver disease
SO GASTROENTEROLOGY
LA English
DT Article
ID ENDOPLASMIC-RETICULUM STRESS; JUN NH2-TERMINAL KINASE;
   INSULIN-RESISTANCE; GENE-EXPRESSION; TNF-ALPHA; STEATOHEPATITIS;
   TRANSCRIPTION; INFLAMMATION; PREVALENCE; APOPTOSIS
AB Background & Aims: Nonalcoholic fatty liver (NAFL) and nonalcoholic steatohepatitis (NASH) are associated with known triggers of the unfolded protein response (UPR). The aims were to (1) evaluate the activity of UPR in NAFL and NASH and (2) correlate expression of UPR pathways with liver histology. Methods: Messenger RNA (mRNA) and protein expression were measured by quantitative real-time PCR and Western blot, respectively. Apoptosis was assessed by TUNEL assay. Liver histology was scored using the NASH clinical research network criteria. Results: Compared with subjects with the metabolic syndrome and normal liver histology (n = 17), both NAFL (n = 21) and NASH (n = 21) were associated with increased eukaryotic initiation factor-2 alpha (eIf-2 alpha) phosphorylation. Activating transcription factor 4 (ATF4) mRNA and protein, C/EBP homologous protein (CHOP), and growth arrest, DNA damage-34 (GADD34) mRNA were not increased in NAFL or NASH. Whereas immunoglobulin heavy chain binding protein mRNA was significantly increased in NASH, unspliced X-box protein-1 (XBP-1) protein did not increase. Also, endoplasmic reticulum degradation-enhancing alpha-mannosidase-like protein mRNA levels were inversely related to spliced XBP-1 mRNA in NASH. NASH was specifically associated with low sXBP-1 protein and increased JNK phosphorylation. This correlated with increased TUNEL activity in NASH. The histologic severity correlated with sXBP-1 mRNA and JNK phosphorylation. Conclusions: There is a variable degree of UPR activation in NAFL and NASH. Although both NAFL and NASH are associated with eIF-2 alpha phosphorylation, there is a failure to activate downstream recovery pathways, ie, ATF4-CHOP-GADD34. NASH is specifically associated with (1) failure to generate sXBP-1 protein and (2) activation of JNK.
C1 [Puri, Puneet; Mirshahi, Faridoddin; Cheung, Onpan; Sanyal, Arun J.] Virginia Commonwealth Univ, Med Ctr, Dept Internal Med, Div Gastroenterol Hepatol & Nutr, Richmond, VA USA.
   [Natarajan, Ramesh] Virginia Commonwealth Univ, Med Ctr, Div Gastrointestinal & Minimally Invas Surg, Dept Surg, Richmond, VA USA.
   [Maher, James W.; Kellum, John M.] Virginia Commonwealth Univ, Med Ctr, Dept Internal Med, Div Pulm Med, Richmond, VA USA.
C3 Virginia Commonwealth University; Virginia Commonwealth University;
   Virginia Commonwealth University
RP Sanyal, AJ (corresponding author), MCV Box 980341,11th & Marshall St, Richmond, VA 23298 USA.
EM ajsanyal@hsc.vcu.edu
RI Kellum, John/LQK-0924-2024
OI Natarajan, Ramesh/0000-0002-3431-9971
FU NIDDK NIH HHS [K24 DK 02755-07, T32 DK 007150-32] Funding Source:
   Medline; PHS HHS [R01 56331] Funding Source: Medline
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NR 36
TC 468
Z9 526
U1 1
U2 41
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0016-5085
EI 1528-0012
J9 GASTROENTEROLOGY
JI Gastroenterology
PD FEB
PY 2008
VL 134
IS 2
BP 568
EP 576
DI 10.1053/j.gastro.2007.10.039
PG 9
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 260TI
UT WOS:000253032900026
PM 18082745
OA Bronze
DA 2025-06-11
ER

PT J
AU Schattenberg, JM
   Singh, R
   Wang, YJ
   Lefkowitch, JH
   Rigoli, RM
   Scherer, PE
   Czaja, MJ
AF Schattenberg, JM
   Singh, R
   Wang, YJ
   Lefkowitch, JH
   Rigoli, RM
   Scherer, PE
   Czaja, MJ
TI JNK1 but not JNK2 promotes the development of steatohepatitis in mice
SO HEPATOLOGY
LA English
DT Article
ID NONALCOHOLIC FATTY LIVER; N-TERMINAL KINASE; HEPATIC CYTOCHROME-P450
   2E1; ACTIVATED PROTEIN-KINASE; C-JUN; INSULIN-RESISTANCE; TNF-ALPHA;
   SENSITIZES HEPATOCYTES; SUSTAINED ACTIVATION; CELL-DEATH
AB Nonalcoholic fatty liver disease (NAFLD) is characterized by hepatic steatosis and varying degrees of necroinflammation. Although chronic oxidative stress, inflammatory cytokines, and insulin resistance have been implicated in the pathogenesis of NAFLD, the mechanisms that underlie the initiation and progression of this disease remain unknown. c-Jun N-terminal kinase (JNK) is activated by oxidants and cytokines and regulates hepatocellular injury and insulin resistance, suggesting that this kinase may mediate the development of steatohepatitis. The presence and function of JNK activation were therefore examined in the murine methionine- and choline-deficient (MCD) diet model of steatohepatitis. Activation of hepatic JNK, c-Jun, and AP-1 signaling occurred in parallel with the development of steatohepatitis in MCD diet-fed mice. Investigations in jnk1 and jnk2 knockout mice demonstrated that jnk1, but not jnk2, was critical for MCD diet-induced JNK activation. JNK promoted the development of steatohepatitis as MCD diet-fed jnk1 null mice had significantly reduced levels of hepatic triglyceride accumulation, inflammation, lipid peroxidation, liver injury, and apoptosis compared with wild-type and juk2 -/- mice. Ablation of jnk1 led to an increase in serum adiponectin but had no effect on serum levels of tumor necrosis factor-a. In conclusion, JNK1 is responsible for JNK activation that promotes the development of steatohepatitis in the MCD diet model. These findings also provide additional support for the critical mechanistic involvement of JNK1 overactivation in conditions associated with insulin resistance and the metabolic syndrome. Supplementary material for this article can be found on the HEPATOLOGY website (http://interscience.wiley.com/jpages/0270-9139/suppmat/index.html).
C1 Albert Einstein Coll Med, Marion Bessin Liver Res Ctr, Bronx, NY 10461 USA.
   Albert Einstein Coll Med, Dept Med, Bronx, NY 10461 USA.
   Albert Einstein Coll Med, Dept Cell Biol, Bronx, NY 10461 USA.
   Columbia Univ, Med Ctr, Dept Pathol, New York, NY USA.
C3 Montefiore Medical Center; Albert Einstein College of Medicine; Yeshiva
   University; Montefiore Medical Center; Albert Einstein College of
   Medicine; Yeshiva University; Yeshiva University; Montefiore Medical
   Center; Albert Einstein College of Medicine; Columbia University
RP Albert Einstein Coll Med, Marion Bessin Liver Res Ctr, 1300 Morris Pk Ave, Bronx, NY 10461 USA.
EM czaja@aecom.yu.edu
RI Schattenberg, Jörn/C-1301-2013; Scherer, Philipp/K-7819-2012
OI Schattenberg, Jorn M./0000-0002-4224-4703
FU NIDDK NIH HHS [R01 DK061498, DK61498, DK55758] Funding Source: Medline
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NR 42
TC 326
Z9 362
U1 1
U2 23
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0270-9139
EI 1527-3350
J9 HEPATOLOGY
JI Hepatology
PD JAN
PY 2006
VL 43
IS 1
BP 163
EP 172
DI 10.1002/hep.20999
PG 10
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 000KH
UT WOS:000234460000022
PM 16374858
OA Bronze
DA 2025-06-11
ER

PT J
AU Qi, WY
   Zheng, SH
   Li, SZ
   Wang, W
   Wang, QY
   Liu, QY
   Li, XK
   Zhang, JX
   Gan, DN
   Ye, YA
   Zao, XB
AF Qi, Wen-Ying
   Zheng, Shi-Hao
   Li, Si-Ze
   Wang, Wei
   Wang, Qiu-Yue
   Liu, Qi-Yao
   Li, Xiao-Ke
   Zhang, Jia-Xin
   Gan, Da-Nan
   Ye, Yong-An
   Zao, Xiao-Bin
TI Immune cells in metabolic associated fatty liver disease: Global trends
   and hotspots (2004-2024)
SO WORLD JOURNAL OF HEPATOLOGY
LA English
DT Article
DE Bibliometrics; Global research effort; Immune cells; Metabolic
   associated fatty liver disease; Research trends
ID NONALCOHOLIC STEATOHEPATITIS; KUPFFER CELLS; MACROPHAGES; ACCUMULATION;
   MECHANISMS
AB BACKGROUND The interplay between immune cells and metabolic associated fatty liver disease (MAFLD) is a critical research frontier, bridging immunology and hepatology. The bibliometric findings can guide future research and funding priorities in the field by highlighting key areas of focus and potential therapeutic targets. AIM To analyze the literature on immune cells and MAFLD, identifying research trends and future hotspots. METHODS A systematic search in the Web of Science Core Collection from January 1, 2004 to May 20, 2024, yielded 1936 articles on immune cells and MAFLD. Excluding non-research documents, the data were analyzed using R packages Cluster profiler, enrichplot, ggplot2, VOSviewer and CiteSpace. Visualizations were created for countries, institutions, authors, journals, fields, co-cited references, keywords, genes, and diseases, with gene a disease data from Citexs. RESULTS The field gained momentum in 2006, with the United States of America and China as leading contributors. Key research themes included oxidative stress, metabolic syndrome, liver fibrosis, and the role of Kupffer cells. Bioinformatics identified interleukin-6, tumor necrosis factor and signal transducer and activator of transcription 3 as central proteins in immune responses and inflammation, suggesting potential therapeutic targets for MAFLD. Clinically, these hub genes play pivotal roles in the pathogenesis of MAFLD. For instance, targeting the tumor necrosis factor signaling pathway could reduce inflammation, while modulating interleukin-6 and signal transducer and activator of transcription 3 expression may improve metabolic function, offering new strategies for MAFLD therapy. CONCLUSION This bibliometric analysis reports on the research hotspots and emerging trends in the field of immune cells and MAFLD, highlighting key proteins and potential therapeutic strategies through bioinformatics.
C1 [Qi, Wen-Ying; Zheng, Shi-Hao; Li, Si-Ze; Wang, Wei; Wang, Qiu-Yue; Liu, Qi-Yao; Li, Xiao-Ke; Zhang, Jia-Xin; Gan, Da-Nan; Ye, Yong-An; Zao, Xiao-Bin] Beijing Univ Chinese Med, Dongzhimen Hosp, Dept Spleen & Stomach Dis, 5 Haiyuncang Rd, Beijing 100700, Peoples R China.
   [Liu, Qi-Yao; Li, Xiao-Ke; Zhang, Jia-Xin; Gan, Da-Nan; Ye, Yong-An; Zao, Xiao-Bin] Beijing Univ Chinese Med, Dongzhimen Hosp, Inst Hepatol, Beijing 100700, Peoples R China.
   [Liu, Qi-Yao; Zao, Xiao-Bin] Beijing Univ Chinese Med, Dongzhimen Hosp, Key Lab Chinese Internal Med, Minist Educ, Beijing 100700, Peoples R China.
C3 Beijing University of Chinese Medicine; Beijing University of Chinese
   Medicine; Ministry of Education - China; Beijing University of Chinese
   Medicine
RP Ye, YA; Zao, XB (corresponding author), Beijing Univ Chinese Med, Dongzhimen Hosp, Dept Spleen & Stomach Dis, 5 Haiyuncang Rd, Beijing 100700, Peoples R China.; Ye, YA; Zao, XB (corresponding author), Beijing Univ Chinese Med, Dongzhimen Hosp, Inst Hepatol, Beijing 100700, Peoples R China.; Zao, XB (corresponding author), Beijing Univ Chinese Med, Dongzhimen Hosp, Key Lab Chinese Internal Med, Minist Educ, Beijing 100700, Peoples R China.
EM a3417@bucm.edu.cn
RI zheng, shihao/GWV-1261-2022; Zao, Xiaobin/GQH-6052-2022; Qi,
   Wenying/MCI-9586-2025
FU Horizontal Project of Dongzhimen Hospital [HX-DZM-202343]
FX Supported by Horizontal Project of Dongzhimen Hospital, No.
   HX-DZM-202343.
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NR 42
TC 0
Z9 0
U1 0
U2 0
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 7041 Koll Center Parkway, Suite 160, PLEASANTON, CA, UNITED STATES
SN 1948-5182
J9 WORLD J HEPATOL
JI World J. Hepatol.
PD MAR 27
PY 2025
VL 17
IS 3
AR 103327
DI 10.4254/wjh.v17.i3.103327
PG 18
WC Gastroenterology & Hepatology
WE Emerging Sources Citation Index (ESCI)
SC Gastroenterology & Hepatology
GA 0WA1R
UT WOS:001457355900004
PM 40177204
DA 2025-06-11
ER

PT J
AU Monteiro, J
   Bicho, M
   Valente, A
AF Monteiro, Jessica
   Bicho, Manuel
   Valente, Ana
TI The Contribution of Precision Nutrition Intervention in Subfertile
   Couples
SO NUTRIENTS
LA English
DT Review
DE precision nutrition; nutrigenetics; subfertility; couples; Mediterranean
   pattern; obesity; macronutrients; micronutrients
ID BODY-MASS INDEX; POLYCYSTIC-OVARY-SYNDROME; ASSISTED REPRODUCTIVE
   TECHNOLOGY; OBESE INFERTILE WOMEN; TERM-FOLLOW-UP; SEMEN QUALITY;
   METABOLIC SYNDROME; ERECTILE DYSFUNCTION; INSULIN-RESISTANCE; DIETARY
   PATTERNS
AB Background/Aim: Subfertility is characterized by a decrease in reproductive efficiency, which can result in delayed pregnancy, and affects one in six individuals during their lifetime. The present narrative review aims to evaluate the contribution of precision nutrition to changes in fertility in subfertile couples. Methods: The literature review was carried out through bibliographic research in the PubMed, Scopus, SciELO and Google Scholar databases. The following search criteria were applied: (1) original articles and narrative, systematic or meta-analytic reviews, and (2) the individual or combined use of the following keywords: "genetic variation", "nutrigenetics", "precision nutrition", "couple's subfertility", and "couple's infertility". A preliminary reading of all the articles was carried out, and only those that best fit the themes and subthemes of the narrative review were selected. Results: Scientific evidence suggests that adherence to a healthy diet that follows the Mediterranean pattern is associated with increased fertility in women and improved semen quality in men, better metabolic health and reduced levels of inflammation and oxidative stress, as well as maintaining a healthy body weight. The integration of different tools, such as nutrigenetics, predictive biochemical analyses, intestinal microbiota tests and clinical nutrition software, used in precision nutrition interventions can contribute to providing information on how diet and genetics interact and how they can influence fertility. Conclusions: The adoption of a multidisciplinary and precision approach allows the design of dietary and lifestyle recommendations adapted to the specific characteristics and needs of couples with subfertility, thus optimizing reproductive health outcomes and achieving successful conception.
C1 [Monteiro, Jessica; Valente, Ana] Egas Moniz Sch Hlth & Sci, Egas Moniz Ctr Interdisciplinary Res CiiEM, Nutr Lab, Appl Nutr Res Grp GENA, P-2829511 Caparica, Portugal.
   [Bicho, Manuel; Valente, Ana] Univ Lisbon, ISAMB Inst Environm Hlth, Lisbon Sch Med, Associate Lab TERRA,Ecogenet & Human Hlth Res Grp, P-1649028 Lisbon, Portugal.
   [Bicho, Manuel] Inst Sci Res Bento Rocha Cabral, Calcada Bento Rocha Cabral 14, P-1250012 Lisbon, Portugal.
C3 Universidade de Lisboa
RP Valente, A (corresponding author), Egas Moniz Sch Hlth & Sci, Egas Moniz Ctr Interdisciplinary Res CiiEM, Nutr Lab, Appl Nutr Res Grp GENA, P-2829511 Caparica, Portugal.; Valente, A (corresponding author), Univ Lisbon, ISAMB Inst Environm Hlth, Lisbon Sch Med, Associate Lab TERRA,Ecogenet & Human Hlth Res Grp, P-1649028 Lisbon, Portugal.
EM jessica.valente.monteiro15@gmail.com; manuelbicho@medicina.ulisboa.pt;
   avalente@egasmoniz.edu.pt
RI Valente, Ana/L-8165-2016
OI Valente, Ana/0000-0003-4039-4326; Monteiro, Jessica/0009-0002-9429-3184;
   Bicho, Manuel/0000-0002-5773-5687
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NR 235
TC 1
Z9 1
U1 3
U2 3
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JAN
PY 2025
VL 17
IS 1
AR 103
DI 10.3390/nu17010103
PG 24
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA R8G1N
UT WOS:001393755500001
PM 39796537
OA gold
DA 2025-06-11
ER

PT J
AU Pappe, CL
   Peters, B
   Pivovarova-Ramich, O
   Schremmer, R
   Adam, A
   Vach, K
   Dommisch, H
   Woelber, JP
AF Pappe, Christina L.
   Peters, Beeke
   Pivovarova-Ramich, Olga
   Schremmer, Robert
   Adam, Aysegul
   Vach, Kirstin
   Dommisch, Henrik
   Woelber, Johan P.
TI Effects of a 4-week free-sugar avoidance during periodontal therapy: An
   explorative randomized controlled clinical trial
SO JOURNAL OF PERIODONTOLOGY
LA English
DT Article; Early Access
DE bleeding on probing; nutrition; periodontal inflammation; periodontal
   therapy; sugar; vitamin c; western diet
ID OXIDATIVE STRESS; SYSTEMIC INFLAMMATION; HEALTH IMPLICATIONS; METABOLIC
   SYNDROME; ORAL CONDITIONS; GLYCEMIC INDEX; DIETARY FIBER; GLOBAL BURDEN;
   VITAMIN-C; DISEASE
AB Background: This study investigated the effect of a 4-week free-sugar avoidance on periodontal parameters during periodontal therapy. Methods: Twenty-one patients with untreated periodontitis and daily free-sugar intake were allocated to a sugar avoidance group (SAG) and a control group (CG). The SAG received a 45-min dietary consultation and was instructed to avoid free sugars during the following 4 weeks after subgingival instrumentation, while the CG continued with their regular diet. Bleeding on probing (BOP), plaque control record, body weight (BW), visceral fat (FATv), and a food frequency questionnaire (FFQ) were collected at baseline (T1), 4 weeks (T2), and 8 weeks (T3) after subgingival instrumentation. Results: The main outcome parameter BOP was significantly reduced at T2 by 40.3% +/- 15.54 in the SAG and 34% +/- 12.47 in the CG (intra-p value both <0.001, inter-p value 0.361). A linear regression analysis of changes at patient level adjusted for age and FATv revealed a significant group difference for BOP (regression coefficient = -6.8; p = 0.019). Significant reductions were observed in BW, FATv and mean daily intake of free sugars (-14.4 g/day), and a significant increase of vitamin C derived from fruits (75.89 mg/day) at T2 in the SAG only. Conclusion: This study may indicate additional beneficial effects of a sugar avoidance on periodontal and metabolic parameters, and nutritional intake during periodontal therapy. German Clinical Trials Register (DRKS00026699).
C1 [Pappe, Christina L.; Schremmer, Robert; Adam, Aysegul; Dommisch, Henrik] Charite Univ Med Berlin, Dept Periodontol Oral Med & Oral Surg, D-14197 Berlin, Germany.
   [Peters, Beeke; Pivovarova-Ramich, Olga] German Inst Human Nutr Potsdam Rehbrucke, Res Grp Mol Nutr Med, Nuthetal, Germany.
   [Peters, Beeke; Pivovarova-Ramich, Olga] German Inst Human Nutr Potsdam Rehbrucke, Dept Human Nutr, Nuthetal, Germany.
   [Peters, Beeke; Pivovarova-Ramich, Olga] German Ctr Diabet Res DZD, Munich, Germany.
   [Pivovarova-Ramich, Olga] Free Univ Berlin, Dept Endocrinol & Metab, Berlin, Germany.
   [Pivovarova-Ramich, Olga] Humboldt Univ, Berlin, Germany.
   [Pivovarova-Ramich, Olga] Charite Univ Med Berlin, Berlin, Germany.
   [Vach, Kirstin] Hannover Med Sch, Dept Conservat Dent Periodontol & Prevent Dent, Hannover, Germany.
   [Vach, Kirstin] Univ Freiburg, Fac Med, Dept Operat Dent & Periodontol, Freiburg, Germany.
   [Vach, Kirstin] Univ Freiburg, Med Ctr, Freiburg, Germany.
   [Woelber, Johan P.] Tech Univ Dresden, Med Fac Carl Gustav Carus, Policlin Operat Dent Periodontol & Pediat Dent, Dresden, Germany.
C3 Berlin Institute of Health; Free University of Berlin; Humboldt
   University of Berlin; Charite Universitatsmedizin Berlin; Leibniz
   Association; Deutsches Institut fur Ernahrungsforschung
   Potsdam-Rehbrucke (DIfE); Leibniz Association; Deutsches Institut fur
   Ernahrungsforschung Potsdam-Rehbrucke (DIfE); German Center for Diabetes
   Research (DZD); Free University of Berlin; Humboldt University of
   Berlin; Berlin Institute of Health; Free University of Berlin; Humboldt
   University of Berlin; Charite Universitatsmedizin Berlin; Hannover
   Medical School; University of Freiburg; University of Freiburg;
   Technische Universitat Dresden; Carl Gustav Carus University Hospital
RP Pappe, CL (corresponding author), Charite Univ Med Berlin, Dept Periodontol Oral Med & Oral Surg, D-14197 Berlin, Germany.; Pappe, CL (corresponding author), Free Univ Berlin, D-14197 Berlin, Germany.; Pappe, CL (corresponding author), Humboldt Univ, Dept Periodontol Oral Med & Oral Surg, D-14197 Berlin, Germany.
EM christina-laetitia.pappe@charite.de
RI Woelber, Johan/AFX-4559-2022; Ramich, Olga/AAK-5663-2020; Vach,
   Kirstin/GQH-9050-2022
OI Vach, Kirstin/0000-0001-9278-2203; Woelber, Johan
   Peter/0000-0003-0921-4630; Pappe, Christina Laetitia/0000-0002-0645-704X
FX The authors kindly thank the entire staff of the Department of
   Periodontology, Oral Medicine and Oral Surgery, Charite -
   Universitatsmedizin Berlin for supporting the study during the
   examination process.
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NR 84
TC 0
Z9 0
U1 3
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-3492
EI 1943-3670
J9 J PERIODONTOL
JI J. Periodont.
PD 2024 AUG 26
PY 2024
DI 10.1002/JPER.24-0208
EA AUG 2024
PG 16
WC Dentistry, Oral Surgery & Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dentistry, Oral Surgery & Medicine
GA D7V7F
UT WOS:001298229300001
PM 39185702
OA hybrid
DA 2025-06-11
ER

PT J
AU Vazquez-Moreno, M
   Perales-Herrera, A
   Ramírez-Silva, I
   Martínez-Gómez, LE
   García-Cerón, A
   Paredes-Barrientos, JC
   Hernández-Mendoza, H
   Martinez-Garza, S
   Murillo-Ortiz, B
   Cruz, M
AF Vazquez-Moreno, Miguel
   Perales-Herrera, Araceli
   Ramirez-Silva, Ivonne
   Martinez-Gomez, Laura E.
   Garcia-Ceron, Angelica
   Paredes-Barrientos, Jorge C.
   Hernandez-Mendoza, Hector
   Martinez-Garza, Sandra
   Murillo-Ortiz, Blanca
   Cruz, Miguel
TI Dietary Zinc Intake and the Association of Insulin Level and HOMA-IR
   with Telomere Shortening in Mexican Children
SO BIOLOGICAL TRACE ELEMENT RESEARCH
LA English
DT Article
DE Obesity; Insulin resistance; Telomere length; Dietary zinc intake;
   Mexican children
ID OXIDATIVE DNA-DAMAGE; METABOLIC SYNDROME; LENGTH; RESISTANCE;
   SUPPLEMENTATION; ADOLESCENTS; OBESITY; STRESS
AB PurposeThe relationship between dietary zinc (Zn) intake, metabolic diseases, and telomere length has been little explored in the children population. This observational cross-sectional study assesses the association between obesity (OB), cardiometabolic traits, telomere length, and dietary Zn intake in children with normal weight (NW) and OB from Mexico City.MethodsAnthropometric data, blood pressure, biochemical measurements, the homeostatic model assessment of insulin resistance (HOMA-IR) and leucocyte telomere length (determined by quantitative-PCR) were analyzed in 171 children with NW and 172 with OB. Furthermore, dietary Zn intake was evaluated in 117 children NW and 120 with OB.ResultsTelomere shortening was associated with fasting plasma insulin (FPI) and HOMA-IR in NW (beta coefficient [beta]FPI = -0.022 +/- 0.008, p = 0.009; beta HOMA-IR = -0.096 +/- 0.040, p = 0.020) and OB (beta FPI = -0.007 +/- 0.002, p = 0.003; beta HOMA-IR = -0.034 +/- 0.012, p = 0.005) children. Dietary Zn intake resulted negatively associated with FPI (beta = -2.418 +/- 0.764, p = 0.002) and HOMA-IR (beta = -0.399 +/- 0.014, p = 0.009) in children with OB. Then, in children with OB, the association between FPI, HOMA-IR, and telomere shortening was evaluated separately in groups of low, medium, and high dietary Zn intake (according to tertiles). The association between FPI, HOMA-IR, and telomere shortening was not significant in the high Zn intake group (PFPI = 0.633; PHOMA-IR = 0.567).ConclusionOur results suggest that a high Zn intake may ameliorate the telomere shortening related to high FPI and HOMA-IR.
C1 [Vazquez-Moreno, Miguel; Perales-Herrera, Araceli; Cruz, Miguel] Hosp Especial, Ctr Med Nacl Siglo 21, Unidad Invest Med Bioquim, Inst Mexicano Seguro Social,Hosp Especialidades, Ave Cuauhtemoc 330, Mexico City 06720, Mexico.
   [Perales-Herrera, Araceli] Univ Ctr Mexico, Programa Licenciatura Nutr, SLP, San Luis Potosi 78250, Mexico.
   [Ramirez-Silva, Ivonne] Inst Nacl Salud Publ, Ctr Invest Nutr & Salud, Av Uni 655, Cuernavaca 62100, Morelos, Mexico.
   [Martinez-Gomez, Laura E.] Inst Nacl RehabilLuis Guillermo Ibarra Ibarra, Lab Gerociencias, Secretaria Salud, Mexico City, Mexico.
   [Garcia-Ceron, Angelica] Inst Mexicano Seguro Social, Unidad Med Familiar 23, Mexico City, Mexico.
   [Paredes-Barrientos, Jorge C.] Inst Mexicano Seguro Social, Unidad Med Familiar 02, Mexico City, Mexico.
   [Hernandez-Mendoza, Hector] Univ Autonoma San Luis Potosi, Inst Invest Zonas Desert, SLP, Altair 200, San Luis Potosi 78377, Mexico.
   [Hernandez-Mendoza, Hector] Univ Ctr Mexico, Capitan Caldera 75, San Luis Potosi 78250, Slp, Mexico.
   [Martinez-Garza, Sandra; Murillo-Ortiz, Blanca] Inst Mexicano Seguro Social, Unidad Invest Epidemiol Clin, Unidad Med Alta Especialidad Bajio OOAD Guanajuato, Leon, Guanajuato, Mexico.
C3 Instituto Mexicano del Seguro Social; Instituto Nacional de Salud
   Publica; Instituto Mexicano del Seguro Social; Instituto Mexicano del
   Seguro Social; Universidad Autonoma de San Luis Potosi; Instituto
   Mexicano del Seguro Social
RP Cruz, M (corresponding author), Hosp Especial, Ctr Med Nacl Siglo 21, Unidad Invest Med Bioquim, Inst Mexicano Seguro Social,Hosp Especialidades, Ave Cuauhtemoc 330, Mexico City 06720, Mexico.; Murillo-Ortiz, B (corresponding author), Inst Mexicano Seguro Social, Unidad Invest Epidemiol Clin, Unidad Med Alta Especialidad Bajio OOAD Guanajuato, Leon, Guanajuato, Mexico.
EM bomo907@hotmail.com; mcruzl@yahoo.com
RI Martínez-Gómez, Laura Edith/IWE-4471-2023; Ortiz, Blanca/ABD-4523-2020;
   Vazquez-Moreno, Miguel/AAQ-7077-2021; Cruz Lopez, Miguel/O-5493-2018
OI Martinez-Gomez, Laura Edith/0000-0003-3198-1350; Cruz Lopez,
   Miguel/0000-0001-9985-6172
FU Instituto Mexicano del Seguro Social
FX We thank all participants of this study.
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NR 47
TC 0
Z9 0
U1 0
U2 1
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0163-4984
EI 1559-0720
J9 BIOL TRACE ELEM RES
JI Biol. Trace Elem. Res.
PD APR
PY 2025
VL 203
IS 4
BP 2114
EP 2121
DI 10.1007/s12011-024-04329-8
EA AUG 2024
PG 8
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 0HK4Y
UT WOS:001285467700001
PM 39110381
DA 2025-06-11
ER

PT J
AU Fresa, K
   Catandi, GD
   Whitcomb, L
   Gonzalez-Castro, RA
   Chicco, AJ
   Carnevale, EM
AF Fresa, Kyle
   Catandi, Giovana D.
   Whitcomb, Luke
   Gonzalez-Castro, Raul A.
   Chicco, Adam J.
   Carnevale, Elaine M.
TI Adiposity in mares induces insulin dysregulation and mitochondrial
   dysfunction which can be mitigated by nutritional intervention
SO SCIENTIFIC REPORTS
LA English
DT Article
DE Equine; Muscle; Systemic; Metabolism; Insulin dysregulation; Obesity;
   Mitochondrial dysfunction
ID POLYUNSATURATED FATTY-ACIDS; EQUINE METABOLIC SYNDROME; SKELETAL-MUSCLE;
   L-CARNITINE; OXIDATIVE STRESS; RESISTANCE; SENSITIVITY; OBESITY;
   HYPERINSULINEMIA; ANTIOXIDANT
AB Obesity is a complex disease associated with augmented risk of metabolic disorder development and cellular dysfunction in various species. The goal of the present study was to investigate the impacts of obesity on the metabolic health of old mares as well as test the ability of diet supplementation with either a complex blend of nutrients designed to improve equine metabolism and gastrointestinal health or L-carnitine alone to mitigate negative effects of obesity. Mares (n = 19, 17.9 +/- 3.7 years) were placed into one of three group: normal-weight (NW, n = 6), obese (OB, n = 7) or obese fed a complex diet supplement for 12 weeks (OBD, n = 6). After 12 weeks and completion of sample collections, OB mares received L-carnitine alone for an additional 6 weeks. Obesity in mares was significantly associated with insulin dysregulation, reduced muscle mitochondrial function, and decreased skeletal muscle oxidative capacity with greater ROS production when compared to NW. Obese mares fed the complex diet supplement had better insulin sensivity, greater cell lipid metabolism, and higher muscle oxidative capacity with reduced ROS production than OB. L-carnitine supplementation alone did not significantly alter insulin signaling, but improved lipid metabolism and muscle oxidative capacity with reduced ROS. In conclusion, obesity is associated with insulin dysregulation and altered skeletal muscle metabolism in older mares. However, dietary interventions are an effective strategy to improve metabolic status and skeletal muscle mitochondrial function in older mares.
C1 [Fresa, Kyle; Catandi, Giovana D.; Whitcomb, Luke; Gonzalez-Castro, Raul A.; Chicco, Adam J.; Carnevale, Elaine M.] Colorado State Univ, Dept Biomed Sci, Ft Collins, CO 80523 USA.
C3 Colorado State University System; Colorado State University Fort Collins
RP Carnevale, EM (corresponding author), Colorado State Univ, Dept Biomed Sci, Ft Collins, CO 80523 USA.
EM elaine.carnevale@colostate.edu
RI Gonzalez-Castro, Raul/AIE-5321-2022
OI Whitcomb, Luke/0000-0003-4857-1323
FU Cecil and Irene Hylton Foundation
FX Advanced nutritional supplement formulas were provided by Platinum
   Performance, Inc., Buellton, CA. Dr. Darci Agin assisted with dietary
   supplements, and Jordan Marsh (Veterinary Summer Scholars Program)
   participated in mare procedures.
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NR 75
TC 1
Z9 1
U1 0
U2 0
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD JUN 18
PY 2024
VL 14
IS 1
AR 13992
DI 10.1038/s41598-024-64628-x
PG 17
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA UZ1G4
UT WOS:001251789700008
PM 38886475
OA Green Submitted, gold, Green Published
DA 2025-06-11
ER

PT J
AU Boullard, NG
   Paris, JJ
   Shariat-Madar, Z
   Mahdi, F
AF Boullard, Nicholas Glen
   Paris, Jason J.
   Shariat-Madar, Zia
   Mahdi, Fakhri
TI Increased Prolylcarboxypeptidase Expression Can Serve as a Biomarker of
   Senescence in Culture
SO MOLECULES
LA English
DT Article
DE cardiovascular dysfunction; metabolic syndrome; renin-angiotensin
   system; kallikrein-kinin system; human telomerase reverse transcriptase;
   complex I inhibitor
ID INTRACELLULAR SUPEROXIDE FORMATION; ENDOTHELIAL CELLULAR SENESCENCE;
   NITRIC-OXIDE; RENIN-ANGIOTENSIN; OXIDATIVE STRESS; COMPLEX-I; PLASMA;
   CELLS; INHIBITION; ACTIVATION
AB Prolylcarboxypeptidase (PRCP, PCP, Lysosomal Pro-X-carboxypeptidase, Angiotensinase C) controls angiotensin- and kinin-induced cell signaling. Elevation of PRCP appears to be activated in chronic inflammatory diseases [cardiovascular disease (CVD), diabetes] in proportion to severity. Vascular endothelial cell senescence and mitochondrial dysfunction have consistently been shown in models of CVD in aging. Cellular senescence, a driver of age-related dysfunction, can differentially alter the expression of lysosomal enzymes due to lysosomal membrane permeability. There is a lack of data demonstrating the effect of age-related dysfunction on the expression and function of PRCP. To explore the changes in PRCP, the PRCP-dependent prekallikrein (PK) pathway was characterized in early- and late-passage human pulmonary artery endothelial cells (HPAECs). Detailed kinetic analysis of cells treated with high molecular weight kininogen (HK), a precursor of bradykinin (BK), and PK revealed a mechanism by which senescent HPAECs activate the generation of kallikrein upon the assembly of the HK-PK complex on HPAECs in parallel with an upregulation of PRCP and endothelial nitric oxide (NO) synthase (eNOS) and NO formation. The NO production and expression of both PRCP and eNOS increased in early-passage HPAECs and decreased in late-passage HPAECs. Low activity of PRCP in late-passage HPAECs was associated with rapid decreased telomerase reverse transcriptase mRNA levels. We also found that, with an increase in the passage number of HPAECs, reduced PRCP altered the respiration rate. These results indicated that aging dysregulates PRCP protein expression, and further studies will shed light into the complexity of the PRCP-dependent signaling pathway in aging.
C1 [Boullard, Nicholas Glen] Jackson Hinds Comprehens Hlth Ctr, Jackson, MS 39216 USA.
   [Paris, Jason J.; Shariat-Madar, Zia; Mahdi, Fakhri] Univ Mississippi, Sch Pharm, Div Pharmacol, Oxford, MS 38677 USA.
C3 University of Mississippi
RP Mahdi, F (corresponding author), Univ Mississippi, Sch Pharm, Div Pharmacol, Oxford, MS 38677 USA.
EM msmca.gluckstadt@gmail.com; parisj@olemiss.edu; madar@olemiss.edu;
   fmahdi@olemiss.edu
OI /0000-0002-5628-1134; Mahdi, Fakhri/0000-0003-4891-2992
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NR 90
TC 1
Z9 1
U1 1
U2 4
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1420-3049
J9 MOLECULES
JI Molecules
PD MAY
PY 2024
VL 29
IS 10
AR 2219
DI 10.3390/molecules29102219
PG 19
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA SG4V2
UT WOS:001233299300001
PM 38792081
OA gold
DA 2025-06-11
ER

PT J
AU Ushida, T
   Tano, S
   Imai, K
   Matsuo, S
   Kajiyama, H
   Kotani, T
AF Ushida, Takafumi
   Tano, Sho
   Imai, Kenji
   Matsuo, Seiko
   Kajiyama, Hiroaki
   Kotani, Tomomi
TI Postpartum and interpregnancy care of women with a history of
   hypertensive disorders of pregnancy
SO HYPERTENSION RESEARCH
LA English
DT Review
DE Cardiovascular Disease; Hypertensive disorders of pregnancy;
   Interpregnancy care, Metabolic syndrome, Postpartum care
ID CARDIOVASCULAR-DISEASE RISK; PRETERM PREECLAMPSIA; UNITED-STATES;
   ASPIRIN; HEALTH; PREVENTION; INTERVENTION; INFLAMMATION; FEASIBILITY;
   VALIDATION
AB Hypertensive disorders of pregnancy (HDP) are common complications associated with maternal and neonatal morbidity and mortality worldwide. Insights gained from long-term cohort studies have revealed that women with a history of HDP are predisposed to recurrent HDP in subsequent pregnancies and face heightened risks for cardiovascular and metabolic diseases later in life. Pregnancy is a unique condition that overloads maternal cardiac and metabolic functions, and is recognized as a "maternal stress test" for future cardiovascular and metabolic diseases. Pregnancy and postpartum period provide a valuable opportunity for identifying women with underlying and unrecognized cardiovascular and metabolic risk factors. Establishing an effective postpartum healthcare program for women who have experienced HDP is crucial in reducing the future risk of health complications. Postpartum care consists of supportive care for both mothers and children, including not only the assessment of physical and psychological well-being but also long-term postpartum preventive health management. Interpregnancy care is a continuum from postpartum care and includes supportive care to prepare for future pregnancies. Various initiatives across nations have been initiated to establish follow-up programs for women with a history of HDP; however, sufficient evidence of the impact of such programs is not available. Substantial challenges persist in establishing an efficient postpartum follow-up program, including educational strategies, selection of effective lifestyle interventions, and collaboration among various healthcare providers. This review outlines the postpartum and interpregnancy care of women who have experienced HDP as well as the current status and challenges of related healthcare initiatives in Japan.
C1 [Ushida, Takafumi; Tano, Sho; Imai, Kenji; Matsuo, Seiko; Kajiyama, Hiroaki; Kotani, Tomomi] Nagoya Univ, Dept Obstet & Gynecol, Grad Sch Med, 65 Tsurumai Cho,Showa Ku, Nagoya 4668550, Japan.
   [Ushida, Takafumi; Tano, Sho; Imai, Kenji; Matsuo, Seiko; Kotani, Tomomi] Nagoya Univ Hosp, Ctr Maternal Neonatal Care, Div Reprod & Perinatol, 65 Tsurumai Cho,Showa Ku, Nagoya 4668550, Japan.
C3 Nagoya University; Nagoya University
RP Ushida, T (corresponding author), Nagoya Univ, Dept Obstet & Gynecol, Grad Sch Med, 65 Tsurumai Cho,Showa Ku, Nagoya 4668550, Japan.; Ushida, T (corresponding author), Nagoya Univ Hosp, Ctr Maternal Neonatal Care, Div Reprod & Perinatol, 65 Tsurumai Cho,Showa Ku, Nagoya 4668550, Japan.
EM u-taka23@med.nagoya-u.ac.jp
RI Kotani, Tomomi/JCD-8082-2023; tano, sho/GXN-1133-2022
FU Japan Society for the Promotion of Science (JSPS KAKENHI) [22K16857];
   Yamaguchi Endocrine Research Foundation; Grants-in-Aid for Scientific
   Research [22K09638, 23KK0157, 22K16857] Funding Source: KAKEN
FX This study was supported by grants awarded to TU by the Japan Society
   for the Promotion of Science (JSPS KAKENHI 22K16857) and Yamaguchi
   Endocrine Research Foundation.
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NR 94
TC 6
Z9 6
U1 0
U2 5
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0916-9636
EI 1348-4214
J9 HYPERTENS RES
JI Hypertens. Res.
PD JUN
PY 2024
VL 47
IS 6
BP 1457
EP 1469
DI 10.1038/s41440-024-01641-7
EA MAR 2024
PG 13
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA TD7W7
UT WOS:001180752800008
PM 38467793
DA 2025-06-11
ER

PT J
AU Chandrasekaran, P
   Weiskirchen, R
AF Chandrasekaran, Preethi
   Weiskirchen, Ralf
TI The Role of Obesity in Type 2 Diabetes Mellitus-An Overview
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE obesity; type 2 diabetes; pathophysiology; incidence; prevalence;
   management; therapeutic approach; in vivo studies; clinical trials
ID IMPROVES INSULIN-RESISTANCE; ADIPOSE-TISSUE; OXIDATIVE STRESS; METABOLIC
   SYNDROME; WEIGHT MANAGEMENT; PEPTIDE-1 ANALOG; FAT ACCUMULATION; MOUSE
   MODEL; WHITE; OVERWEIGHT
AB Obesity or excessive weight gain is identified as the most important and significant risk factor in the development and progression of type 2 diabetes mellitus (DM) in all age groups. It has reached pandemic dimensions, making the treatment of obesity crucial in the prevention and management of type 2 DM worldwide. Multiple clinical studies have demonstrated that moderate and sustained weight loss can improve blood glucose levels, insulin action and reduce the need for diabetic medications. A combined approach of diet, exercise and lifestyle modifications can successfully reduce obesity and subsequently ameliorate the ill effects and deadly complications of DM. This approach also helps largely in the prevention, control and remission of DM. Obesity and DM are chronic diseases that are increasing globally, requiring new approaches to manage and prevent diabetes in obese individuals. Therefore, it is essential to understand the mechanistic link between the two and design a comprehensive approach to increase life expectancy and improve the quality of life in patients with type 2 DM and obesity. This literature review provides explicit information on the clinical definitions of obesity and type 2 DM, the incidence and prevalence of type 2 DM in obese individuals, the indispensable role of obesity in the pathophysiology of type 2 DM and their mechanistic link. It also discusses clinical studies and outlines the recent management approaches for the treatment of these associated conditions. Additionally, in vivo studies on obesity and type 2 DM are discussed here as they pave the way for more rigorous development of therapeutic approaches.
C1 [Chandrasekaran, Preethi] UT Southwestern Med Ctr Dallas, 5323 Harry Hines Blvd ND10 504, Dallas, TX 75390 USA.
   [Weiskirchen, Ralf] Univ Hosp Aachen, Rheinisch Westfalische TH RWTH, Inst Mol Pathobiochem Expt Gene Therapy & Clin Che, D-52074 Aachen, Germany.
C3 RWTH Aachen University; RWTH Aachen University Hospital
RP Chandrasekaran, P (corresponding author), UT Southwestern Med Ctr Dallas, 5323 Harry Hines Blvd ND10 504, Dallas, TX 75390 USA.; Weiskirchen, R (corresponding author), Univ Hosp Aachen, Rheinisch Westfalische TH RWTH, Inst Mol Pathobiochem Expt Gene Therapy & Clin Che, D-52074 Aachen, Germany.
EM Preethi.Chandrasekaran@utsouthwestern.edu; rweiskirchen@ukaachen.de
RI Chandrasekaran, Preethi/AAD-6554-2021; Weiskirchen, Ralf/O-1734-2018
OI Chandrasekaran, Preethi/0000-0002-1581-6008; Weiskirchen,
   Ralf/0000-0003-3888-0931
FU German Research Foundation
FX The authors are grateful to Sabine Weiskirchen (IFMPEGKC, RWTH
   University Hospital Aachen, Germany) for helping in drawing Figure 3,
   Figure 4, Figure 5 and Figure 6 for this review.
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NR 127
TC 90
Z9 92
U1 45
U2 109
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD FEB
PY 2024
VL 25
IS 3
AR 1882
DI 10.3390/ijms25031882
PG 21
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA HO0Y0
UT WOS:001160339000001
PM 38339160
OA gold
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Lilly, AC
   Astsaturov, I
   Golemis, EA
AF Lilly, Anna C.
   Astsaturov, Igor
   Golemis, Erica A.
TI Intrapancreatic fat, pancreatitis, and pancreatic cancer
SO CELLULAR AND MOLECULAR LIFE SCIENCES
LA English
DT Review
DE Ductal cells; Cilia; Pancreatic steatosis; PDAC; Lipids
ID PEUTZ-JEGHERS SYNDROME; BETA-CELL FUNCTION; METABOLIC SYNDROME; PRIMARY
   CILIA; ECTOPIC FAT; TRANSCRIPTIONAL CONTROL; INSULIN-RESISTANCE;
   EXOCRINE PANCREAS; ONCOGENIC KRAS; ACINAR-CELLS
AB Pancreatic cancer is typically detected at an advanced stage, and is refractory to most forms of treatment, contributing to poor survival outcomes. The incidence of pancreatic cancer is gradually increasing, linked to an aging population and increasing rates of obesity and pancreatitis, which are risk factors for this cancer. Sources of risk include adipokine signaling from fat cells throughout the body, elevated levels of intrapancreatic intrapancreatic adipocytes (IPAs), inflammatory signals arising from pancreas-infiltrating immune cells and a fibrotic environment induced by recurring cycles of pancreatic obstruction and acinar cell lysis. Once cancers become established, reorganization of pancreatic tissue typically excludes IPAs from the tumor microenvironment, which instead consists of cancer cells embedded in a specialized microenvironment derived from cancer-associated fibroblasts (CAFs). While cancer cell interactions with CAFs and immune cells have been the topic of much investigation, mechanistic studies of the source and function of IPAs in the pre-cancerous niche are much less developed. Intriguingly, an extensive review of studies addressing the accumulation and activity of IPAs in the pancreas reveals that unexpectedly diverse group of factors cause replacement of acinar tissue with IPAs, particularly in the mouse models that are essential tools for research into pancreatic cancer. Genes implicated in regulation of IPA accumulation include KRAS, MYC, TGF-& beta;, periostin, HNF1, and regulators of ductal ciliation and ER stress, among others. These findings emphasize the importance of studying pancreas-damaging factors in the pre-cancerous environment, and have significant implications for the interpretation of data from mouse models for pancreatic cancer.
C1 [Lilly, Anna C.; Astsaturov, Igor; Golemis, Erica A.] Fox Chase Canc Ctr, Program Canc Signaling & Microenvironm, 333 Cottman Ave, Philadelphia, PA 19111 USA.
   [Lilly, Anna C.] Drexel Univ, Coll Med, Mol & Cell Biol & Genet MCBG Program, Philadelphia, PA 19102 USA.
   [Astsaturov, Igor] Fox Chase Canc Ctr, Marvin & Concetta Greenberg Pancreat Canc Inst, Philadelphia, PA 19111 USA.
   [Golemis, Erica A.] Lewis Katz Sch Med, Dept Canc & Cellular Biol, Philadelphia, PA 19140 USA.
C3 Fox Chase Cancer Center; Drexel University; Fox Chase Cancer Center
RP Golemis, EA (corresponding author), Fox Chase Canc Ctr, Program Canc Signaling & Microenvironm, 333 Cottman Ave, Philadelphia, PA 19111 USA.; Golemis, EA (corresponding author), Lewis Katz Sch Med, Dept Canc & Cellular Biol, Philadelphia, PA 19140 USA.
EM Erica.Golemis@fccc.edu
RI ASTSATUROV, Igor/AAG-4099-2021
OI Golemis, Erica/0000-0003-3618-3673; Lilly, Anna/0000-0002-0385-6088
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NR 191
TC 19
Z9 21
U1 2
U2 9
PU SPRINGER BASEL AG
PI BASEL
PA PICASSOPLATZ 4, BASEL, 4052, SWITZERLAND
SN 1420-682X
EI 1420-9071
J9 CELL MOL LIFE SCI
JI Cell. Mol. Life Sci.
PD AUG
PY 2023
VL 80
IS 8
AR 206
DI 10.1007/s00018-023-04855-z
PG 25
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA M6NA4
UT WOS:001031351400003
PM 37452870
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Vafaeipour, Z
   Rahbardar, MG
   Hosseinzadeh, H
AF Vafaeipour, Zeinab
   Rahbardar, Mahboobeh Ghasemzadeh
   Hosseinzadeh, Hossein
TI Effect of saffron, black seed, and their main constituents on
   inflammatory cytokine response (mainly TNF-α) and oxidative stress
   status: an aspect on pharmacological insights
SO NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
LA English
DT Review
DE Crocus; Nigella sativa; Antioxidants; Tumor Necrosis Factors;
   Phytochemicals; Cytokines
ID TUMOR-NECROSIS-FACTOR; ALVEOLAR EPITHELIAL-CELLS; NRF2 SIGNALING
   PATHWAY; INDUCED LIVER-INJURY; CROCUS-SATIVUS L.; NIGELLA-SATIVA;
   DOUBLE-BLIND; RHEUMATOID-ARTHRITIS; METABOLIC SYNDROME; KAPPA-B
AB Tumor necrosis factor-alpha (TNF-alpha), an inflammatory cytokine, is produced by monocytes and macrophages. It is known as a 'double-edged sword' because it is responsible for advantageous and disadvantageous events in the body system. The unfavorable incident includes inflammation, which induces some diseases such as rheumatoid arthritis, obesity, cancer, and diabetes. Many medicinal plants have been found to prevent inflammation, such as saffron (Crocus sativus L.) and black seed (Nigella sativa). Therefore, the purpose of this review was to assess the pharmacological effects of saffron and black seed on TNF-alpha and diseases related to its imbalance. Different databases without time limitations were investigated up to 2022, including PubMed, Scopus, Medline, and Web of Science. All the original articles (in vitro, in vivo, and clinical studies) were collected on the effects of black seed and saffron on TNF-alpha. Black seed and saffron have therapeutic effects against many disorders, such as hepatotoxicity, cancer, ischemia, and non-alcoholic fatty liver, by decreasing TNF-alpha levels based on their anti-inflammatory, anticancer, and antioxidant properties. Saffron and black seed can treat a variety of diseases by suppressing TNF-alpha and exhibiting a variety of activities such as neuroprotective, gastroprotective, immunomodulatory, antimicrobial, analgesic, antitussive, bronchodilator, antidiabetic activity, anticancer, and antioxidant effects. To uncover the beneficial underlying mechanisms of black seed and saffron, more clinical trials and phytochemical research are required. Also, these two plants affect other inflammatory cytokines, hormones, and enzymes, implying that they could be used to treat a variety of diseases.
C1 [Vafaeipour, Zeinab] Mashhad Univ Med Sci, Student Res Comm, Mashhad, Iran.
   [Vafaeipour, Zeinab; Hosseinzadeh, Hossein] Mashhad Univ Med Sci, Sch Pharm, Dept Pharmacodynam & Toxicol, Mashhad, Iran.
   [Rahbardar, Mahboobeh Ghasemzadeh; Hosseinzadeh, Hossein] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Pharmaceut Res Ctr, Mashhad, Iran.
C3 Mashhad University of Medical Sciences; Mashhad University of Medical
   Sciences; Mashhad University of Medical Sciences
RP Hosseinzadeh, H (corresponding author), Mashhad Univ Med Sci, Sch Pharm, Dept Pharmacodynam & Toxicol, Mashhad, Iran.; Hosseinzadeh, H (corresponding author), Mashhad Univ Med Sci, Pharmaceut Technol Inst, Pharmaceut Res Ctr, Mashhad, Iran.
EM VafaeipourZ971@mums.ac.ir; GhasemzadehRM962@mums.ac.ir;
   hosseinzadehh@mums.ac.ir
RI Ghasemzadeh Rahbardar, Mahboobeh/V-4452-2019; Hosseinzadeh,
   Hossein/F-3013-2010
OI Ghasemzadeh Rahbardar, Mahboobeh/0000-0002-5491-572X
FU Mashhad University of Medical Sciences, Mashhad, Iran
FX AcknowledgementsThe authors are thankful to the Vice-Chancellor of
   Research, Mashhad University of Medical Sciences, Mashhad, Iran, for
   their support.
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NR 164
TC 9
Z9 9
U1 2
U2 7
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0028-1298
EI 1432-1912
J9 N-S ARCH PHARMACOL
JI Naunyn-Schmiedebergs Arch. Pharmacol.
PD OCT
PY 2023
VL 396
IS 10
BP 2241
EP 2259
DI 10.1007/s00210-023-02501-w
EA APR 2023
PG 19
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA U5JR7
UT WOS:000978198700001
PM 37103518
DA 2025-06-11
ER

PT J
AU Kataoka, H
   Nitta, K
   Hoshino, J
AF Kataoka, Hiroshi
   Nitta, Kosaku
   Hoshino, Junichi
TI Visceral fat and attribute-based medicine in chronic kidney disease
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Review
DE visceral fat; patient-centered medicine; sex difference; personalized
   medicine; obesity; precision medicine; chronic kidney disease;
   attribute-based medicine
ID RENIN-ANGIOTENSIN SYSTEM; BODY-MASS INDEX; OBESITY-RELATED
   GLOMERULOPATHY; SUBCUTANEOUS ADIPOSE-TISSUE; INCIDENT
   CARDIOVASCULAR-DISEASE; METABOLICALLY HEALTHY OBESITY; STAGE
   RENAL-DISEASE; RISK-FACTORS; REPLACEMENT THERAPY; COMPUTED-TOMOGRAPHY
AB Visceral adipose tissue plays a central role in obesity and metabolic syndrome and is an independent risk factor for both cardiovascular and metabolic disorders. Increased visceral adipose tissue promotes adipokine dysregulation and insulin resistance, leading to several health issues, including systemic inflammation, oxidative stress, and activation of the renin-angiotensin-aldosterone system. Moreover, an increase in adipose tissue directly and indirectly affects the kidneys by increasing renal sodium reabsorption, causing glomerular hyperfiltration and hypertrophy, which leads to increased proteinuria and kidney fibrosis/dysfunction. Although the interest in the adverse effects of obesity on renal diseases has grown exponentially in recent years, the relationship between obesity and renal prognosis remains controversial. This may be attributed to the long clinical course of obesity, numerous obesity-related metabolic complications, and patients' attributes. Multiple individual attributes influencing the pathophysiology of fat accumulation make it difficult to understand obesity. In such cases, it may be effective to elucidate the pathophysiology by conducting research tailored to individual attributes from the perspective of attribute-based medicine/personalized medicine. We consider the appropriate use of clinical indicators necessary, according to attributes such as chronic kidney disease stage, level of visceral adipose tissue accumulation, age, and sex. Selecting treatments and clinical indicators based on individual attributes will allow for advancements in the clinical management of patients with obesity and chronic kidney disease. In the clinical setting of obesity-related nephropathy, it is first necessary to accumulate attribute-based studies resulting from the accurate evaluation of visceral fat accumulation to establish evidence for promoting personalized medicine.
C1 [Kataoka, Hiroshi; Nitta, Kosaku; Hoshino, Junichi] Tokyo Womens Med Univ, Dept Nephrol, Tokyo, Japan.
C3 Tokyo Women's Medical University
RP Kataoka, H (corresponding author), Tokyo Womens Med Univ, Dept Nephrol, Tokyo, Japan.
EM kataoka@twmu.ac.jp
RI Kataoka, Hiroshi/AAL-8850-2021
FU Ministry of Health, Labor and Welfare of Japan
FX This study was partly supported by a Grant-in-Aid for Intractable Renal
   Diseases Research and Research on Rare and Intractable Diseases, as well
   as by Health and Labor Sciences Research Grants from the Ministry of
   Health, Labor and Welfare of Japan.
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NR 213
TC 19
Z9 19
U1 0
U2 6
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD FEB 9
PY 2023
VL 14
AR 1097596
DI 10.3389/fendo.2023.1097596
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 9D4RL
UT WOS:000936087000001
PM 36843595
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Zhang, RT
   Shi, SS
   Chen, WH
   Wang, YN
   Lin, XQ
   Zhao, YK
   Liao, LH
   Guo, Q
   Zhang, XY
   Li, WG
   Zhang, KJ
   Liao, Y
   Fang, Y
AF Zhang, Rongting
   Shi, Shanshan
   Chen, Weihua
   Wang, Yani
   Lin, Xueqin
   Zhao, Yukun
   Liao, Lihua
   Guo, Qian
   Zhang, Xiaoying
   Li, Weiguo
   Zhang, Kaijun
   Liao, Ying
   Fang, Yong
TI Independent effects of the triglyceride-glucose index on all-cause
   mortality in critically ill patients with coronary heart disease:
   analysis of the MIMIC-III database
SO CARDIOVASCULAR DIABETOLOGY
LA English
DT Article
DE Triglyceride-glucose index; Insulin resistance; Coronary heart disease;
   All-cause mortality; MIMIC-III database
ID CARDIOVASCULAR OUTCOMES; MYOCARDIAL-INFARCTION; STRESS HYPERGLYCEMIA;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; TYG INDEX; IMPACT
AB BackgroundThe triglyceride-glucose (TyG) index is a reliable alternative biomarker of insulin resistance (IR). However, whether the TyG index has prognostic value in critically ill patients with coronary heart disease (CHD) remains unclear.MethodsParticipants from the Medical Information Mart for Intensive Care III (MIMIC-III) were grouped into quartiles according to the TyG index. The primary outcome was in-hospital all-cause mortality. Cox proportional hazards models were constructed to examine the association between TyG index and all-cause mortality in critically ill patients with CHD. A restricted cubic splines model was used to examine the associations between the TyG index and outcomes.ResultsA total of 1,618 patients (65.14% men) were included. The hospital mortality and intensive care unit (ICU) mortality rate were 9.64% and 7.60%, respectively. Multivariable Cox proportional hazards analyses indicated that the TyG index was independently associated with an elevated risk of hospital mortality (HR, 1.71 [95% CI 1.25-2.33] P = 0.001) and ICU mortality (HR, 1.50 [95% CI 1.07-2.10] P = 0.019). The restricted cubic splines regression model revealed that the risk of hospital mortality and ICU mortality increased linearly with increasing TyG index (P for non-linearity = 0.467 and P for non-linearity = 0.764).ConclusionsThe TyG index was a strong independent predictor of greater mortality in critically ill patients with CHD. Larger prospective studies are required to confirm these findings.
C1 [Zhang, Rongting; Shi, Shanshan; Chen, Weihua; Wang, Yani; Lin, Xueqin; Zhao, Yukun; Liao, Lihua; Guo, Qian; Zhang, Xiaoying; Li, Weiguo; Liao, Ying; Fang, Yong] Fujian Med Univ, Longyan Affiliated Hosp 1, Dept Cardiol, Longyan 364000, Peoples R China.
   [Zhang, Rongting; Shi, Shanshan; Chen, Weihua; Wang, Yani; Lin, Xueqin; Zhao, Yukun; Liao, Lihua; Guo, Qian; Zhang, Xiaoying] Fujian Med Univ, Grad Sch Clin Med, Fuzhou 350000, Peoples R China.
   [Zhang, Kaijun] Fujian Med Univ, Longyan Affiliated Hosp 1, Dept Pulm & Crit Care Med, Longyan 364000, Peoples R China.
C3 Fujian Medical University; Fujian Medical University; Fujian Medical
   University
RP Liao, Y; Fang, Y (corresponding author), Fujian Med Univ, Longyan Affiliated Hosp 1, Dept Cardiol, Longyan 364000, Peoples R China.; Zhang, KJ (corresponding author), Fujian Med Univ, Longyan Affiliated Hosp 1, Dept Pulm & Crit Care Med, Longyan 364000, Peoples R China.
EM 420780660@qq.com; wingjays@163.com; fjly7008@163.com
RI Li, Weiguo/H-8502-2019; Chen, Weihua/AAC-8587-2022; Liao,
   Lihua/HMV-5908-2023; Zhang, Rongting/AAD-9929-2020; liao,
   ying/O-5321-2016; 张, 晓颖/ABD-9142-2021
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NR 41
TC 79
Z9 82
U1 6
U2 27
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1475-2840
J9 CARDIOVASC DIABETOL
JI Cardiovasc. Diabetol.
PD JAN 13
PY 2023
VL 22
IS 1
AR 10
DI 10.1186/s12933-023-01737-3
PG 12
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism
GA 9W3UK
UT WOS:000949005000001
PM 36639637
OA gold, Green Published
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Yang, BD
   Xin, ML
   Liang, SF
   Xu, XX
   Cai, TQ
   Dong, L
   Wang, C
   Wang, M
   Cui, YT
   Song, XH
   Sun, JY
   Sun, WL
AF Yang, Bendong
   Xin, Meiling
   Liang, Shufei
   Xu, Xiaoxue
   Cai, Tianqi
   Dong, Ling
   Wang, Chao
   Wang, Meng
   Cui, Yuting
   Song, Xinhua
   Sun, Jinyue
   Sun, Wenlong
TI New insight into the management of renal excretion and hyperuricemia:
   Potential therapeutic strategies with natural bioactive compounds
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Review
DE hyperuricemia; urate transporters; natural products; chronic kidney
   disease; renal urate extraction
ID SERUM URIC-ACID; GENOME-WIDE ASSOCIATION; INDUCED ENDOTHELIAL
   DYSFUNCTION; CAPACITY URATE TRANSPORTER; ORGANIC ANION TRANSPORTERS;
   RENIN-ANGIOTENSIN SYSTEM; CHRONIC KIDNEY-DISEASE; 3RD NATIONAL-HEALTH;
   POST-HOC ANALYSIS; MOLECULAR-IDENTIFICATION
AB Hyperuricemia is the result of increased production and/or underexcretion of uric acid. Hyperuricemia has been epidemiologically associated with multiple comorbidities, including metabolic syndrome, gout with long-term systemic inflammation, chronic kidney disease, urolithiasis, cardiovascular disease, hypertension, rheumatoid arthritis, dyslipidemia, diabetes/insulin resistance and increased oxidative stress. Dysregulation of xanthine oxidoreductase (XOD), the enzyme that catalyzes uric acid biosynthesis primarily in the liver, and urate transporters that reabsorb urate in the renal proximal tubules (URAT1, GLUT9, OAT4 and OAT10) and secrete urate (ABCG2, OAT1, OAT3, NPT1, and NPT4) in the renal tubules and intestine, is a major cause of hyperuricemia, along with variations in the genes encoding these proteins. The first-line therapeutic drugs used to lower serum uric acid levels include XOD inhibitors that limit uric acid biosynthesis and uricosurics that decrease urate reabsorption in the renal proximal tubules and increase urate excretion into the urine and intestine via urate transporters. However, long-term use of high doses of these drugs induces acute kidney disease, chronic kidney disease and liver toxicity. Therefore, there is an urgent need for new nephroprotective drugs with improved safety profiles and tolerance. The current systematic review summarizes the characteristics of major urate transporters, the mechanisms underlying the pathogenesis of hyperuricemia, and the regulation of uric acid biosynthesis and transport. Most importantly, this review highlights the potential mechanisms of action of some naturally occurring bioactive compounds with antihyperuricemic and nephroprotective potential isolated from various medicinal plants.
C1 [Yang, Bendong; Xin, Meiling; Liang, Shufei; Xu, Xiaoxue; Cai, Tianqi; Dong, Ling; Wang, Chao; Wang, Meng; Cui, Yuting; Song, Xinhua; Sun, Wenlong] Shandong Univ Technol, Sch Life Sci & Med, Zibo, Peoples R China.
   [Song, Xinhua; Sun, Wenlong] Shandong Qingyujiangxing Biotechnol Co Ltd, Zibo, Peoples R China.
   [Sun, Jinyue] Shandong Acad Agr Sci, Inst Agrofood Sci & Technol, Key Lab Novel Food Resources Proc, Key Lab Agroprod Proc Technol Shandong Prov,Minist, Jinan, Peoples R China.
C3 Shandong University of Technology; Shandong Academy of Agricultural
   Sciences
RP Song, XH; Sun, WL (corresponding author), Shandong Univ Technol, Sch Life Sci & Med, Zibo, Peoples R China.; Song, XH; Sun, WL (corresponding author), Shandong Qingyujiangxing Biotechnol Co Ltd, Zibo, Peoples R China.; Sun, JY (corresponding author), Shandong Acad Agr Sci, Inst Agrofood Sci & Technol, Key Lab Novel Food Resources Proc, Key Lab Agroprod Proc Technol Shandong Prov,Minist, Jinan, Peoples R China.
EM 512649113@qq.com; moon_s731@hotmail.com; 892442572@qq.com
RI sun, wenlong/HCH-0574-2022; Cui, Yuting/LKK-4286-2024; song,
   xinhua/W-4764-2019; SUN, JINYUE/GSM-8554-2022
FU Subproject of Major Science and Technology Innovation Project of
   Shandong Province [2019JZZY020612]; Zhangdian School-City Integrated
   Development Project [2021PT0001]; National Natural Science Foundation of
   China [81903878]; Natural Science Foundation of Shandong Province
   [ZR202112010171, ZR2022MH306]
FX Subproject of Major Science and Technology Innovation Project of
   Shandong Province (2019JZZY020612), Zhangdian School-City Integrated
   Development Project (2021PT0001), National Natural Science Foundation of
   China (81903878), Natural Science Foundation of Shandong Province
   (ZR202112010171, ZR2022MH306).
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NR 172
TC 27
Z9 30
U1 10
U2 84
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD NOV 22
PY 2022
VL 13
AR 1026246
DI 10.3389/fphar.2022.1026246
PG 17
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 6U5FZ
UT WOS:000894393800001
PM 36483739
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Conte, M
   Petraglia, L
   Cabaro, S
   Valerio, V
   Poggio, P
   Pilato, E
   Attena, E
   Russo, V
   Ferro, A
   Formisano, P
   Leosco, D
   Parisi, V
AF Conte, Maddalena
   Petraglia, Laura
   Cabaro, Serena
   Valerio, Vincenza
   Poggio, Paolo
   Pilato, Emanuele
   Attena, Emilio
   Russo, Vincenzo
   Ferro, Adele
   Formisano, Pietro
   Leosco, Dario
   Parisi, Valentina
TI Epicardial Adipose Tissue and Cardiac Arrhythmias: Focus on Atrial
   Fibrillation
SO FRONTIERS IN CARDIOVASCULAR MEDICINE
LA English
DT Review
DE epicardial adipose tissue; visceral fat; inflammation; atrial
   fibrillation; fibrosis; atrial remodeling; arrhythmogenesis
ID C-REACTIVE PROTEIN; NECROSIS-FACTOR-ALPHA; BODY-FAT DISTRIBUTION;
   METABOLIC SYNDROME; PERICARDIAL FAT; WEIGHT-LOSS; INFLAMMATORY PROFILE;
   BARIATRIC SURGERY; TRANSGENIC MICE; STATIN THERAPY
AB Atrial Fibrillation (AF) is the most frequent cardiac arrhythmia and its prevalence increases with age. AF is strongly associated with an increased risk of stroke, heart failure and cardiovascular mortality. Among the risk factors associated with AF onset and severity, obesity and inflammation play a prominent role. Numerous recent evidence suggested a role of epicardial adipose tissue (EAT), the visceral fat depot of the heart, in the development of AF. Several potential arrhythmogenic mechanisms have been attributed to EAT, including myocardial inflammation, fibrosis, oxidative stress, and fat infiltration. EAT is a local source of inflammatory mediators which potentially contribute to atrial collagen deposition and fibrosis, the anatomical substrate for AF. Moreover, the close proximity between EAT and myocardium allows the EAT to penetrate and generate atrial myocardium fat infiltrates that can alter atrial electrophysiological properties. These observations support the hypothesis of a strong implication of EAT in structural and electrical atrial remodeling, which underlies AF onset and burden. The measure of EAT, through different imaging methods, such as echocardiography, computed tomography and cardiac magnetic resonance, has been proposed as a useful prognostic tool to predict the presence, severity and recurrence of AF. Furthermore, EAT is increasingly emerging as a promising potential therapeutic target. This review aims to summarize the recent evidence exploring the potential role of EAT in the pathogenesis of AF, the main mechanisms by which EAT can promote structural and electrical atrial remodeling and the potential therapeutic strategies targeting the cardiac visceral fat.
C1 [Conte, Maddalena; Petraglia, Laura; Cabaro, Serena; Formisano, Pietro; Leosco, Dario; Parisi, Valentina] Univ Naples Federico II, Dept Translat Med Sci, Naples, Italy.
   [Conte, Maddalena] Casa Cura San Michele, Maddaloni, Italy.
   [Valerio, Vincenza; Poggio, Paolo] Ctr Cardiol Monzino, IRCCS, Milan, Italy.
   [Pilato, Emanuele] Univ Naples Federico II, Dept Adv Biomed Sci, Naples, Italy.
   [Attena, Emilio] Monaldi Hosp, Dept Cardiol, Naples, Italy.
   [Russo, Vincenzo] Univ Campania Luigi Vanvitelli Monaldi, Cotugno Hosp, Chair Cardiol, Dept Translat Med Sci, Naples, Italy.
   [Ferro, Adele] CNR, Inst Biostruct & Bioimaging, Naples, Italy.
C3 University of Naples Federico II; IRCCS Centro Cardiologico Monzino;
   University of Naples Federico II; Consiglio Nazionale delle Ricerche
   (CNR); Istituto di Biostrutture e Bioimmagini (IBB-CNR)
RP Parisi, V (corresponding author), Univ Naples Federico II, Dept Translat Med Sci, Naples, Italy.
EM parisi.valentina@tiscali.it
RI Conte, Maddalena/LSI-9003-2024; Cabaro, Serena/K-7697-2016; Pilato,
   Emanuele/AHE-7982-2022; Valerio, Vincenza/AAC-3794-2022; Poggio,
   Paolo/J-7347-2016; Parisi, Valentina/K-7062-2016; Attena,
   Emilio/IAP-5093-2023; Russo, Vincenzo/ABH-1766-2020
OI Russo, Vincenzo/0000-0002-9227-0360; Conte,
   Maddalena/0000-0002-6840-8593
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NR 153
TC 44
Z9 47
U1 1
U2 9
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2297-055X
J9 FRONT CARDIOVASC MED
JI Front. Cardiovasc. Med.
PD JUN 30
PY 2022
VL 9
AR 932262
DI 10.3389/fcvm.2022.932262
PG 14
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 2Z7BR
UT WOS:000826729000001
PM 35845044
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Chansela, P
   Potip, B
   Weerachayaphorn, J
   Kangwanrangsan, N
   Chukijrungroat, N
   Saengsirisuwan, V
AF Chansela, Piyachat
   Potip, Bubphachat
   Weerachayaphorn, Jittima
   Kangwanrangsan, Niwat
   Chukijrungroat, Natsasi
   Saengsirisuwan, Vitoon
TI Morphological alteration of the pancreatic islet in ovariectomized rats
   fed a high-fat high-fructose diet
SO HISTOCHEMISTRY AND CELL BIOLOGY
LA English
DT Article
DE High-fat high-fructose diet; Estrogen; Insulin resistance; Pancreatic
   beta-cells
ID BETA-CELL APOPTOSIS; INSULIN-RESISTANCE; METABOLIC SYNDROME; OXIDATIVE
   STRESS; SEX-DIFFERENCES; ESTROGEN; GLUCAGON; MODULATION; FAILURE;
   OBESITY
AB Diabetes and its complications are major causes of mortality worldwide. Type 2 diabetes coexists with insulin resistance and beta-cell dysfunction, which are aggravated by overconsumption and estrogen-deprived conditions. However, the morphology of pancreatic islets in a combined condition of excessive caloric intake and estrogen deficiency has never been described. Herein, we examined morphological changes in the pancreatic islets of ovariectomized (OVX) rats fed a high-fat high-fructose diet (HFFD) for 12 weeks. The histological changes in the size and number of pancreatic islets were assessed by hematoxylin-eosin and immunohistochemical staining. Enlarged pancreatic islets with fat deposition in OVX rats were accompanied by whole-body insulin resistance and hyperglycemia. The addition of a HFFD to OVX rats (OVX + HFFD) further aggravated insulin resistance, with a substantial increase in the density of enlarged pancreatic islets and fat accumulation. The augmented number of enlarged islets was correlated with elevated plasma glucose and insulin levels. Intriguingly, unlike the HFFD and OVX alone, the OVX + HFFD markedly expanded the area of insulin-producing beta-cells and glucagon-producing alpha-cells. Importantly, enlarged islets, pancreatic fat deposits, and diabetic states developing in OVX + HFFD conditions were resolved by estrogen replacement. Collectively, the morphological characteristics of pancreatic islets were influenced in an insulin-resistant state caused by estrogen deficiency and HFFD consumption and were distinct from each factor alone. A combination of estrogen deficiency with HFFD consumption worsened the integrity of pancreatic islets, ultimately resulting in disease progression. These findings expand our understanding of the causal relationship between pancreatic morphology and diabetes development and suggest therapeutic strategies.
C1 [Chansela, Piyachat] Phramongkutklao Coll Med, Dept Anat, Bangkok 10400, Thailand.
   [Potip, Bubphachat; Weerachayaphorn, Jittima; Chukijrungroat, Natsasi; Saengsirisuwan, Vitoon] Mahidol Univ, Fac Sci, Dept Physiol, Bangkok 10400, Thailand.
   [Kangwanrangsan, Niwat] Mahidol Univ, Fac Sci, Dept Pathobiol, Bangkok 10400, Thailand.
C3 Phramongkutklao College of Medicine; Mahidol University; Mahidol
   University
RP Saengsirisuwan, V (corresponding author), Mahidol Univ, Fac Sci, Dept Physiol, Bangkok 10400, Thailand.
EM vitoon.sae@mahidol.ac.th
FU Mahidol University; Thailand Research Fund [RSA-5780009, RSA-6080072]
FX This study was partly supported by Mahidol University and the Thailand
   Research Fund (RSA-5780009 to VS and RSA-6080072 to JW).
CR Abbas AM, 2011, CAN J PHYSIOL PHARM, V89, P497, DOI 10.1139/Y11-053
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NR 40
TC 3
Z9 4
U1 0
U2 1
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0948-6143
EI 1432-119X
J9 HISTOCHEM CELL BIOL
JI Histochem. Cell Biol.
PD APR
PY 2022
VL 157
IS 4
BP 427
EP 442
DI 10.1007/s00418-021-02062-0
EA JAN 2022
PG 16
WC Cell Biology; Microscopy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Microscopy
GA 0K8CG
UT WOS:000743015300002
PM 35037128
DA 2025-06-11
ER

PT J
AU Chen, Y
   Huang, HB
   He, XW
   Duan, WW
   Mo, XM
AF Chen, Yong
   Huang, Haobin
   He, Xiaowei
   Duan, Weiwei
   Mo, Xuming
TI Sex differences in the link between blood cobalt concentrations and
   insulin resistance in adults without diabetes
SO ENVIRONMENTAL HEALTH AND PREVENTIVE MEDICINE
LA English
DT Article
DE Cobalt; NHANES; Insulin resistance; HOMA-IR
ID HEME OXYGENASE INDUCER; GLUCOSE-HOMEOSTASIS; METABOLIC SYNDROME;
   OXIDATIVE STRESS; IRON; OBESITY; PROTOPORPHYRIN; INFLAMMATION;
   ABSORPTION; MANGANESE
AB Background Little is known about the effects of environmental cobalt exposure on insulin resistance (IR) in the general adult population. We investigated the association between cobalt concentration and IR. Methods A total of 1281 subjects aged more than 20 years with complete blood cobalt data were identified from the National Health and Nutrition Examination Survey (NHANES) 2015-2016 cycle. Blood cobalt levels were analyzed for their association with IR among all populations and subgroups by sex. Regression coefficients and 95% confidence intervals (CIs) of blood cobalt concentrations in association with fasting glucose, insulin and homeostatic model assessment of insulin resistance (HOMA-IR) were estimated using multivariate linear regression after adjusting for age, sex, ethnicity, alcohol consumption, body mass index, education level, and household income. A multivariate generalized linear regression analysis was further carried out to explore the association between cobalt exposure and IR. Results A negative association between blood cobalt concentration (coefficient = - 0.125, 95% CI - 0.234, - 0.015; P = 0.026) and HOMA-IR in female adults in the age- and sex-adjusted model was observed. However, no associations with HOMA-IR, fasting glucose, or insulin were found in the overall population. In the generalized linear models, participants with the lowest cobalt levels had a 2.74% (95% CI 0.04%, 5.50%) increase in HOMA-IR (P for trend = 0.031) compared with subjects with the highest cobalt levels. Restricted cubic spline regression suggested that a non-linear relationship may exist between blood cobalt and HOMA-IR. Conclusions These results provide epidemiological evidence that low levels of blood cobalt are negatively associated with HOMA-IR in female adults.
C1 [Chen, Yong; Mo, Xuming] Nanjing Med Univ, Childrens Hosp, Dept Cardiothorac Surg, 72 Guangzhou Rd, Nanjing 210008, Peoples R China.
   [Huang, Haobin] Nanjing Med Univ, Dept Cardiovasc Surg, Affiliated Hosp 1, Nanjing 210029, Jiangsu, Peoples R China.
   [He, Xiaowei] Nanjing Med Univ, Jiangsu Prov Official Hosp, Jiangsu Prov Geriatr Hosp,Jiangsu Prov Inst Geria, Dept Endocrinol & Metab,Diabet Care & Res Ctr,Aff, Nanjing, Peoples R China.
   [Duan, Weiwei] Nanjing Med Univ, Sch Biomed Engn & Informat, Dept Bioinformat, 101 Longmian Ave, Nanjing 211166, Peoples R China.
C3 Nanjing Medical University; Nanjing Medical University; Nanjing Medical
   University; Nanjing Medical University
RP Mo, XM (corresponding author), Nanjing Med Univ, Childrens Hosp, Dept Cardiothorac Surg, 72 Guangzhou Rd, Nanjing 210008, Peoples R China.; Duan, WW (corresponding author), Nanjing Med Univ, Sch Biomed Engn & Informat, Dept Bioinformat, 101 Longmian Ave, Nanjing 211166, Peoples R China.
EM passion@njmu.edu.cn; mohsuming15@njmu.edu.cn
RI He, XW/JXN-0620-2024
FU National Science Foundation of China [81903409]
FX This work was supported by funding from the National Science Foundation
   of China (81903409).
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NR 43
TC 16
Z9 16
U1 2
U2 16
PU JAPANESE SOC HYGIENE
PI Kyoto-city
PA 146 Nishioji-cho, Shimodachiuri-dori, Kamigyo-ku,, Kyoto-city, Kyoto,
   JAPAN
SN 1342-078X
EI 1347-4715
J9 ENVIRON HEALTH PREV
JI Environ. Health Prev.
PD MAR 27
PY 2021
VL 26
IS 1
AR 42
DI 10.1186/s12199-021-00966-w
PG 10
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA RD8OD
UT WOS:000633729000001
PM 33773581
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Isaacson, RH
   Beier, JI
   Khoo, NKH
   Freeman, BA
   Freyberg, Z
   Arteel, GE
AF Isaacson, Robin H.
   Beier, Juliane, I
   Khoo, Nicholas K. H.
   Freeman, Bruce A.
   Freyberg, Zachary
   Arteel, Gavin E.
TI Olanzapine-induced liver injury in mice: aggravation by high-fat-diet
   and protection with sulforaphane
SO JOURNAL OF NUTRITIONAL BIOCHEMISTRY
LA English
DT Article
DE Olanzapine; Liver; NAFLD; HFD; Oxidative Stress; Sulforaphane
ID GENE-EXPRESSION PROFILES; ISOTHIOCYANATE SULFORAPHANE;
   CARDIOVASCULAR-DISEASE; ANTIPSYCHOTIC-DRUGS; METABOLIC SYNDROME;
   UNITED-STATES; WEIGHT-GAIN; VITAMIN-E; ETHANOL; OBESITY
AB Olanzapine is effective to treat for schizophrenia and other mood disorders, but limited by side effects such as weight gain, dyslipidemia, and liver injury. Obesity in the US is at epidemic levels, and is a significant risk factor for drug-induced liver injury. Obesity incidence in the psychiatric population is even higher than in the US population as a whole. The purpose of this study was to test the hypothesis that obesity worsens olanzapine-induced hepatic injury, and to investigate the potential protective effects of sulforaphane. 8-week old female C57BL/6 mice were fed either a high-fat or low-fat control diet (HFD and LFD). Mice also received either olanzapine (8 mg/kg/d) or vehide by osmotic minipump for 4 weeks. A subset of mice in the HFD + olanzapine group was administered sulforaphane, a prototypical Nrf2 inducer (90 mg/kg/d). Olanzapine alone increased body weight, without a commensurate increase in food consumption. Olanzapine also caused hepatic steatosis and injury. Combining olanzapine and HFD caused further dysregulation of glucose and lipid metabolism. Liver damage from concurrent HFD and olanzapine was worse than liver damage from high-fat diet or olanzapine alone. Sulforaphane alleviated many metabolic side effects of olanzapine and HFD. Taken together, these data show that olanzapine dysregulates glucose and lipid metabolism and exacerbates hepatic changes caused by eating a HFD. Activation of the intrinsic antioxidant defense pathway with sulforaphane can partially prevent these effects of olanzapine and may represent a useful strategy to protect against liver injury. (C) 2020 Elsevier Inc. All rights reserved.
C1 [Isaacson, Robin H.] Emory Univ, Sch Med, Dept Cell Biol, Atlanta, GA USA.
   [Beier, Juliane, I; Arteel, Gavin E.] Univ Pittsburgh, Dept Med, Div Gastroenterol Hepatot & Nutr, Pittsburgh, PA USA.
   [Beier, Juliane, I; Arteel, Gavin E.] Univ Pittsburgh, Pittsburgh Liver Res Ctr, Pittsburgh, PA USA.
   [Khoo, Nicholas K. H.; Freeman, Bruce A.] Univ Pittsburgh, Dept Pharmacol & Chem Biol, Pittsburgh, PA USA.
   [Freeman, Bruce A.] Univ Pittsburgh, Vasc Med Inst, Pittsburgh, PA USA.
   [Freyberg, Zachary] Univ Pittsburgh, Dept Psychiat, Pittsburgh, PA USA.
C3 Emory University; Pennsylvania Commonwealth System of Higher Education
   (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of
   Higher Education (PCSHE); University of Pittsburgh; Pennsylvania
   Commonwealth System of Higher Education (PCSHE); University of
   Pittsburgh; Pennsylvania Commonwealth System of Higher Education
   (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of
   Higher Education (PCSHE); University of Pittsburgh
RP Arteel, GE (corresponding author), Univ Pittsburgh, Sch Med, Dept Med, Div Gastroenterol Hepatol & Nutr, BST1 W1143,200 Lothrop St, Pittsburgh, PA 15213 USA.
EM gearteel@pitt.edu
RI Arteel, Gavin/AAE-2440-2022; Freyberg, Zachary/L-4927-2018
OI Arteel, Gavin/0000-0002-2253-5984; Freyberg, Zachary/0000-0001-6460-0118
FU NIH [R01AA021978, P50AA024337, P30DK120531, R01HL64937, R01HL132550,
   P01HL103455, K01DK096042]; University of Pittsburgh Medical Center
   CompetitiveMedical Research FundAward;  [T32ES011564]
FX This work was supported by NIH grants R01AA021978,P50AA024337 and
   P30DK120531 (GEA), R01HL64937, R01HL132550 and P01HL103455 (BAF),
   K01DK096042 (JIB) and University of Pittsburgh Medical Center
   CompetitiveMedical Research FundAward (N.K.H.K.). RHIwas supported by a
   predoctoral fellowship (T32ES011564).
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NR 59
TC 29
Z9 29
U1 0
U2 30
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0955-2863
EI 1873-4847
J9 J NUTR BIOCHEM
JI J. Nutr. Biochem.
PD JUL
PY 2020
VL 81
AR 108399
DI 10.1016/j.jnutbio.2020.108399
PG 9
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA LT2VF
UT WOS:000536929100012
PM 32388251
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Weaver, SR
   Rendeiro, C
   McGettrick, HM
   Philp, A
   Lucas, SJE
AF Weaver, Samuel R.
   Rendeiro, Catarina
   McGettrick, Helen M.
   Philp, Andrew
   Lucas, Samuel J. E.
TI Fine wine or sour grapes? A systematic review and meta-analysis of the
   impact of red wine polyphenols on vascular health
SO EUROPEAN JOURNAL OF NUTRITION
LA English
DT Review
DE Red wine; Polyphenols; Resveratrol; Vascular health; Blood pressure
ID TRANS-RESVERATROL SUPPLEMENTATION; IMPROVES ENDOTHELIAL FUNCTION;
   AMBULATORY BLOOD-PRESSURE; NITRIC-OXIDE RELEASE; DOUBLE-BLIND; OXIDATIVE
   STRESS; SEED EXTRACT; METABOLIC SYNDROME; GLYCEMIC CONTROL;
   CARDIOVASCULAR PARAMETERS
AB Purpose Red wine polyphenols (RWP) are plant-based molecules that have been extensively studied in relation to their protective effects on vascular health in both animals and humans. The aim of this review was to quantify and compare the efficacy of RWP and pure resveratrol on outcomes measures of vascular health and function in both animals and humans. Methods Comprehensive database searches were carried out through PubMed, Web of Science and OVID for randomised, placebo-controlled studies in both animals and humans. Meta-analyses were carried out on acute and chronic studies of RWP in humans, alongside sub-group analysis where possible. Risk-of-bias assessment was carried out for all included studies based on randomisation, allocation, blinding, outcome data reporting, and other biases. Results 48 animal and 37 human studies were included in data extraction following screening. Significant improvements in measures of blood pressure and vascular function following RWP were seen in 84% and 100% of animal studies, respectively. Human studies indicated significant improvements in systolic blood pressure overall (- 2.6 mmHg, 95% CI: [- 4.8, - 0.4]), with a greater improvement in pure-resveratrol studies alone (- 3.7 mmHg, 95% CI: [- 7.3, - 0.0]). No significant effects of RWP were seen in diastolic blood pressure or flow-mediated dilation (FMD) of the brachial artery. Conclusion RWP have the potential to improve vascular health in at risk human populations, particularly in regard to lowering systolic blood pressure; however, such benefits are not as prevalent as those observed in animal models.
C1 [Weaver, Samuel R.; Rendeiro, Catarina; Philp, Andrew; Lucas, Samuel J. E.] Univ Birmingham, Coll Life & Environm Sci, Sch Sport, Birmingham B15 2TT, W Midlands, England.
   [Rendeiro, Catarina; Lucas, Samuel J. E.] Univ Birmingham, Ctr Human Brain Hlth, Birmingham B15 2TT, W Midlands, England.
   [McGettrick, Helen M.] Univ Birmingham, Coll Med & Dent Sci, Inst Inflammat & Ageing, Birmingham B15 2WB, W Midlands, England.
   [Philp, Andrew] Garvan Inst Med Res, Darlinghurst, NSW 2010, Australia.
   [Philp, Andrew] UNSW Sydney, St Vincents Clin Sch, UNSW Med, Sydney, NSW 2010, Australia.
C3 University of Birmingham; University of Birmingham; University of
   Birmingham; Garvan Institute of Medical Research; University of New
   South Wales Sydney
RP Weaver, SR (corresponding author), Univ Birmingham, Coll Life & Environm Sci, Sch Sport, Birmingham B15 2TT, W Midlands, England.
EM SRW199@bham.ac.uk
RI Weaver, Samuel/AAY-1821-2020; McGettrick, Helen/H-3442-2011; Lucas,
   Samuel/J-4124-2014
OI Philp, Andrew/0000-0003-3860-4136; Lucas, Samuel/0000-0002-8713-2457;
   Weaver, Sam/0000-0002-6585-1995
FU BBSRC MIBTP Studentship; Arthritis Research UK Career Development
   Fellowship [19899]; BBSRC [1943514] Funding Source: UKRI
FX SRW was supported by a BBSRC MIBTP Studentship. HMM was supported by an
   Arthritis Research UK Career Development Fellowship (19899).
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NR 150
TC 30
Z9 30
U1 1
U2 44
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1436-6207
EI 1436-6215
J9 EUR J NUTR
JI Eur. J. Nutr.
PD FEB
PY 2021
VL 60
IS 1
BP 1
EP 28
DI 10.1007/s00394-020-02247-8
EA APR 2020
PG 28
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA QD5RS
UT WOS:000558383900001
PM 32303823
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Bukhari, SA
   Yasmin, A
   Zahoor, MA
   Mustafa, G
   Sarfraz, I
   Rasul, A
AF Bukhari, Shazia Anwer
   Yasmin, Aysha
   Zahoor, Muhammad Asif
   Mustafa, Ghulam
   Sarfraz, Iqra
   Rasul, Azhar
TI Secreted frizzled-related protein 4 and its implication in obesity and
   type-2 diabetes
SO IUBMB LIFE
LA English
DT Review
DE adipokines; obesity; SFRP4; type-2 diabetes; Wnt signaling
ID LOCALIZED PROSTATE-CANCER; WNT SIGNALING PATHWAY; ADIPOGENIC
   DIFFERENTIATION; INSULIN-SECRETION; EXPRESSION; SFRP4; CELL; BETA;
   INHIBITION; METHYLGLYOXAL
AB Secreted frizzled-related protein 4 (SFRP4) is a member of secreted protein family with sequence similarity to frizzled receptors of wingless-related integration site (Wnt) signaling pathways. These proteins control diverse functions from embryonic development to adults in many organisms including humans. Initially, SFRPs were recognized as antagonists of Wnt signaling and supposed to interact with Wnts. Further research demonstrated their interactions to frizzled receptors and a functional diversity was related to these proteins, Wnt signaling potentiation in addition to modulation. SFRP4 is the largest member of SFRP family and is implicated in many diseases including obesity, type 2 diabetes (T2D), and cancer. SFRP4 acts as a biomarker for T2D and was expressed several years before clinical diagnosis of disease. This review mainly focusses on the role of SFRP4 in obesity and how it can lead to beta-cell failure and ultimately to T2D. The role of SFRP4 in adipose tissues causing increased production of adipokines lead to the oxidative stress in pancreas that particularly have low amount of antioxidant enzymes in pancreatic beta-cells leading to failure in exocytosis of insulin containing granules causing T2D. Obesity-induced inflammation is a principal factor in pathogenesis of insulin resistance as well as metabolic syndrome. Pro-inflammatory cytokines have potential to cause insulin resistance in skeletal muscles, adipose tissue, and liver via inhibition of insulin signal transduction. Secretion of SFRP4 is mediated by interleukin 1-beta (IL1-beta). This review highlights the molecular mechanisms by which SFRP4 leads to T2D. Understanding of molecular mechanism and targeting SFRP4 could help to eradicate or reduce chances of developing T2D.
C1 [Bukhari, Shazia Anwer; Yasmin, Aysha; Mustafa, Ghulam] Govt Coll Univ, Dept Biochem, Faisalabad 38000, Pakistan.
   [Zahoor, Muhammad Asif] Govt Coll Univ, Dept Microbiol, Faisalabad, Pakistan.
   [Sarfraz, Iqra; Rasul, Azhar] Govt Coll Univ, Dept Zool, Faisalabad, Pakistan.
C3 Government College University Faisalabad; Government College University
   Faisalabad; Government College University Faisalabad
RP Bukhari, SA (corresponding author), Govt Coll Univ, Dept Biochem, Faisalabad 38000, Pakistan.; Rasul, A (corresponding author), Govt Coll Univ, Dept Zool, Cell & Mol Biol Lab, Faisalabad 38000, Pakistan.
EM bukhari.shazia@yahoo.com; drazharrasul@gmail.com
RI Rasul, Azhar/AAF-5253-2021; Zahoor, Muhammad Asif/Q-8873-2016; Mustafa,
   Dr. Ghulam/A-1657-2017
OI Zahoor, Muhammad Asif/0000-0002-0895-7312; Rasul,
   Azhar/0000-0001-9669-7364; Mustafa, Dr. Ghulam/0000-0001-6510-6496;
   Yasmin, Aysha/0000-0002-9523-5747
FU HEC Pakistan
FX HEC Pakistan
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NR 75
TC 30
Z9 32
U1 0
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1521-6543
EI 1521-6551
J9 IUBMB LIFE
JI IUBMB Life
PD NOV
PY 2019
VL 71
IS 11
BP 1701
EP 1710
DI 10.1002/iub.2123
EA JUL 2019
PG 10
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA JE0LM
UT WOS:000476229700001
PM 31301214
OA Bronze
DA 2025-06-11
ER

PT J
AU Peng, JM
   Jia, Y
   Hu, TY
   Du, J
   Wang, Y
   Cheng, BH
   Li, KK
AF Peng, Jinming
   Jia, Yan
   Hu, Tianyong
   Du, Jing
   Wang, Yue
   Cheng, Baohui
   Li, Kaikai
TI GC-(4→8)-GCG, A Proanthocyanidin Dimer from Camellia ptilophylla,
   Modulates Obesity and Adipose Tissue Inflammation in High-Fat Diet
   Induced Obese Mice
SO MOLECULAR NUTRITION & FOOD RESEARCH
LA English
DT Article
DE adipose tissue inflammation; anti-inflammation; GC-(4 -> 8)-GCG;
   metabolic syndrome; obesity
ID INDUCED INSULIN-RESISTANCE; ALPHA-GLUCOSIDASE; IN-VITRO; TARGETED
   DISRUPTION; COCOA PROCYANIDINS; OXIDATIVE STRESS; GENE-EXPRESSION; TEA
   EXTRACTS; ABSORPTION; AMYLASE
AB Scope Excessive fat accumulation in adipose tissue leads to obesity and related chronic inflammation. This study aims to examine the effects of gallocatechin -(4 -> 8)-gallocatechin-3-O-gallate (GC-(4 -> 8)-GCG), a main proanthocyanidin dimer from Camellia ptilophylla (Cocoa tea), on adipocyte- and adipose-related inflammation in vivo and in vitro. Methods and results C57BL/6 mice are fed a high-fat diet (HFD) and GC-(4 -> 8)-GCG (40 or 80 mg kg(-1) d(-1)) for 8 weeks. The metabolic profiles, adipose tissue hypertrophy, macrophage infiltration, and inflammatory cytokine production are investigated. Additionally, 3T3-L1 preadipocytes are utilized to investigate the effect of GC-(4 -> 8)-GCG on preadipocyte differentiation and the tumor necrosis factor (TNF)-alpha-stimulated inflammatory response in vitro. GC-(4 -> 8)-GCG supplementation decreases HFD-induced epididymal white adipose tissue (eWAT) hypertrophy, suppresses proinflammatory cytokine production and macrophage infiltration in eWAT, and improves insulin sensitivity in HFD-induced obese mice. In vitro, GC-(4 -> 8)-GCG shows a strong anti-adipogenic potential in 3T3-L1 preadipocyte by inhibiting the expression of key adipogenic transcription factors and decreasing the production of proinflammatory cytokines by inhibiting the activation of the nuclear factor (NF)-kappa B, Janus tyrosine kinase/signal transducer and activator of transcription (JAK/STAT3) and mitogen-activated protein kinase (MAPK) signaling pathways. Conclusion GC-(4 -> 8)-GCG can modulate obesity and improve obesity-related insulin resistance by inhibiting preadipocyte differentiation and the related proinflammatory responses.
C1 [Peng, Jinming; Du, Jing; Wang, Yue; Li, Kaikai] Huazhong Agr Univ, Coll Food Sci & Technol, Wuhan 430070, Hubei, Peoples R China.
   [Jia, Yan] Beijing Technol & Business Univ, Sch Sci, Beijing Key Lab Plant Resource Res & Dev, Beijing 100048, Peoples R China.
   [Hu, Tianyong; Cheng, Baohui] Longgang ENT Hosp, Shenzhen Key Lab ENT, Shenzhen 518172, Peoples R China.
   [Hu, Tianyong; Cheng, Baohui] Inst ENT, Shenzhen 518172, Peoples R China.
   [Li, Kaikai] Huazhong Agr Univ, Minist Educ, Key Lab Environm Correlat Food Sci, Wuhan 430070, Hubei, Peoples R China.
C3 Huazhong Agricultural University; Beijing Technology & Business
   University; Longgang ENT Hospital, Shenzhen; Ministry of Education -
   China; Huazhong Agricultural University
RP Li, KK (corresponding author), Huazhong Agr Univ, Coll Food Sci & Technol, Wuhan 430070, Hubei, Peoples R China.; Li, KK (corresponding author), Huazhong Agr Univ, Minist Educ, Key Lab Environm Correlat Food Sci, Wuhan 430070, Hubei, Peoples R China.
EM likaikai@mail.hzau.edu.cn
RI Li, Kaikai/JZE-4530-2024; Hu, TianYong/AAE-5289-2020
OI Hu, Tian-Yong/0000-0002-1269-093X; Hu, TianYong/0000-0002-4416-6948;
   Peng, Jinming/0000-0002-9630-8696
FU Natural Science Foundation of China [31701712]; Hubei Provincial Natural
   Science Foundation of China [2017CFB197]; Fundamental Research Funds for
   the Central Universities [2662016QD035]; Open Research Fund Program of
   Beijing Key Lab of Plant Resource Research and Development, Beijing
   Technology and Business University [PRRD-2017-YB4]; Longgang Science and
   Technology programs [20160607142024828]
FX K.L. and B.C. are responsible for the design of the research; Y.J.
   checked the whole manuscript, J.P., T.H., and J.D. performed the
   experiments; K.L. and Y.W. interpreted the results of the experiments,
   prepared the figures, and drafted the manuscript; K.L. edited and
   revised the manuscript. All authors read and approved the final version
   of the manuscript.This work was supported by the Natural Science
   Foundation of China (31701712), Hubei Provincial Natural Science
   Foundation of China (2017CFB197), the Fundamental Research Funds for the
   Central Universities (2662016QD035), the Open Research Fund Program of
   Beijing Key Lab of Plant Resource Research and Development, Beijing
   Technology and Business University (PRRD-2017-YB4), Longgang Science and
   Technology programs (No. 20160607142024828).
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NR 59
TC 28
Z9 30
U1 1
U2 65
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1613-4125
EI 1613-4133
J9 MOL NUTR FOOD RES
JI Mol. Nutr. Food Res.
PD JUN
PY 2019
VL 63
IS 11
AR 1900082
DI 10.1002/mnfr.201900082
PG 12
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA IC4EE
UT WOS:000470916800005
PM 30893514
DA 2025-06-11
ER

PT J
AU Driescher, N
   Joseph, DE
   Human, VR
   Ojuka, E
   Cour, M
   Hadebe, N
   Bester, D
   Marnewick, JL
   Lecour, S
   Lochner, A
   Essop, MF
AF Driescher, Natasha
   Joseph, Danzil E.
   Human, Veronique R.
   Ojuka, Edward
   Cour, Martin
   Hadebe, Nkanyiso
   Bester, Dirk
   Marnewick, Jeanine L.
   Lecour, Sandrine
   Lochner, Amanda
   Essop, M. Faadiel
TI The impact of sugar-sweetened beverage intake on rat cardiac function
SO HELIYON
LA English
DT Article
DE Nutrition; Physiology; Cardiology; Molecular biology; Biochemistry
ID HIGH-FAT DIET; URIC-ACID; INSULIN-RESISTANCE; ACUTE HYPERGLYCEMIA;
   METABOLIC SYNDROME; OXIDATIVE STRESS; HIGH-FRUCTOSE; BODY-WEIGHT;
   CONSUMPTION; OBESITY
AB Aims: Although there is evidence linking sugar-sweetened beverage (SSB) intake with the development of cardio-metabolic diseases, the underlying mechanisms remain unclear. The current study therefore evaluated the effects of SSB consumption by establishing a unique in-house in vivo experimental model.
   Main methods: Male Wistar rats were divided into two groups: a) one consuming a popular local SSB (SSB-Jive), and b) a control group (Control-water) for a period of three and six months (n = 6 per group), respectively. Rats were gavaged on a daily basis with an experimental dosage amounting to half a glass per day (in human terms) (SSB vs. water). Cardiac function was assessed at baseline (echocardiography) and following ex vivo ischemia-reperfusion of the isolated perfused working rat heart. Oral glucose tolerance tests and mitochondrial respiratory analyses were also performed. In addition, the role of non-oxidative glucose pathways (NOGPs), i.e. the polyol pathway, hexosamine biosynthetic pathway (HBP) and PKC were assessed.
   Key findings: These data show that SSB intake: a) resulted in increased weight gain, but did not elicit major effects in terms of insulin resistance and cardiac function after three and six months, respectively; b) triggered myocardial NOGP activation after three months with a reversion after six months; and c) resulted in some impairment in mitochondrial respiratory capacity in response to fatty acid substrate supply after six months.
   Significance: SSB intake did not result in cardiac dysfunction or insulin resistance. However, early changes at the molecular level may increase risk in the longer term.
C1 [Driescher, Natasha; Joseph, Danzil E.; Human, Veronique R.; Essop, M. Faadiel] Stellenbosch Univ, Dept Physiol Sci, CMRG, ZA-7600 Stellenbosch, South Africa.
   [Ojuka, Edward] Univ Cape Town, Fac Hlth Sci, Dept Human Biol, Cape Town, South Africa.
   [Cour, Martin; Hadebe, Nkanyiso; Lecour, Sandrine] Univ Cape Town, Dept Med, HICRA, Cape Town, South Africa.
   [Bester, Dirk; Marnewick, Jeanine L.] Cape Peninsula Univ Technol, Fac Hlth & Wellness Sci, Oxidat Stress Res Ctr, Bellville, South Africa.
   [Marnewick, Jeanine L.] Cape Peninsula Univ Technol, Inst Biomed & Microbial Biotechnol, Bellville, South Africa.
   [Lochner, Amanda] Stellenbosch Univ, Fac Med & Hlth Sci, Dept Biomed Sci, ZA-7505 Tygerberg, South Africa.
C3 Stellenbosch University; University of Cape Town; University of Cape
   Town; Cape Peninsula University of Technology; Cape Peninsula University
   of Technology; Stellenbosch University
RP Essop, MF (corresponding author), Stellenbosch Univ, Dept Physiol Sci, CMRG, ZA-7600 Stellenbosch, South Africa.
EM mfessop@sun.ac.za
RI Bester, Dirk/ABB-6544-2021; Cour, M/T-2525-2019; TECHNOLOGY, CAPE
   PENINSULA UNIVERSITY/L-3761-2019; Joseph, Danzil/LFT-9605-2024
OI Bester, Dirk/0000-0002-5871-1011; Joseph, Danzil/0000-0002-0227-1221;
   cour, martin/0000-0003-4909-9761
FU South African National Research Foundation [IFR150119112480];
   Stellenbosch University
FX This study was supported by grants from the South African National
   Research Foundation (IFR150119112480) and Stellenbosch University to M.
   F. Essop. Conceived and designed the experiments; Performed the
   experiments; Analyzed and interpreted the data; Contributed reagents,
   materials, analysis tools or data; Wrote the paper.
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NR 55
TC 3
Z9 4
U1 0
U2 11
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
EI 2405-8440
J9 HELIYON
JI Heliyon
PD MAR
PY 2019
VL 5
IS 3
AR e01357
DI 10.1016/j.heliyon.2019.e01357
PG 28
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA HR3UZ
UT WOS:000463067400077
PM 30949605
OA Green Published
DA 2025-06-11
ER

PT J
AU Jiang, J
   Yin, JN
   Liu, X
   Wang, HJ
   Lu, GY
AF Jiang, Jun
   Yin, Jiangning
   Liu, Xiang
   Wang, Huajun
   Lu, Guoyuan
TI Erzhi Formula Extracts Reverse Renal Injury in Diabetic Nephropathy Rats
   by Protecting the Renal Podocytes
SO EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Article
ID DIAPHRAGM PROTEIN NEPH1; METABOLIC SYNDROME; OXIDATIVE STRESS; OLEANOLIC
   ACID; MECHANISMS; IRBESARTAN; PREVENTS; PODOCIN; MODEL
AB Podocytes injury was a crucial factor resulting in diabetic nephropathy (DN). Erzhi formula extract (EZF) was a clinical effective Chinese medicine on DN, but its mechanism was unclear. In this study, the main compounds of EZF and their pharmacokinetics in rat were detected by HPLC-MS/MS. And then, blood glucose, urine protein, renal index, renal microstructural (HE/PAS staining), inflammatory factors (IL-beta, TNF-alpha, IL-6), and protein/mRNA expression related to the function of podocyte (CD2AP and Podocin) in DN rats were investigated after the oral administration of EZF. The concentrations of specnuezhenide and wedelolactone in rat kidney were 7.19 and 0.057 mg/kg, respectively. The T-max of specnuezhenide and wedelolactone were 2.0 and 1.50 h, respectively. Their C-max were, respectively, 30.24 +/- 2.68 and 6.39 +/- 0.05 mu g/L. Their AUC((0-infinity)) were 123.30 +/- 2.68 and 16.56 +/- 0.98 mu g/L*h, respectively. Compared with the model group, the blood glucose and the 24-hour urinary protein were significantly decreased (P < 0.05) after 16 weeks' treatment of EZF. The expressions of Podocin and CD2AP protein/mRNA were increased (P < 0. 05). The deteriorate of glomerular morphology was alleviated under the treatment of EZF. EZF prominently decreased the levels of inflammatory factors (P < 0.05). MDA was significantly decreased (P < 0.05) with the significant increase of SOD activity (P < 0.05) in EZF groups. All the results proved that EZF repaired glomerular mesangial matrix, protected renal tubule, and improved renal function in DN rats by upregulating the expression of Podocin and CD2AP protein/mRNA in podocytes.
C1 [Jiang, Jun; Liu, Xiang] Jiangsu Univ, Sch Pharm, 301 Xuefu Rd, Zhenjiang 212013, Jiangsu, Peoples R China.
   [Yin, Jiangning; Wang, Huajun] Jiangsu Univ, Affiliated Hosp, 438 Jiefang Rd, Zhenjiang 212001, Jiangsu, Peoples R China.
   [Yin, Jiangning; Lu, Guoyuan] Soochow Univ, Affiliated Hosp 1, 188 Shizi Rd, Suzhou 215006, Jiangsu, Peoples R China.
C3 Jiangsu University; Jiangsu University; Soochow University - China
RP Jiang, J (corresponding author), Jiangsu Univ, Sch Pharm, 301 Xuefu Rd, Zhenjiang 212013, Jiangsu, Peoples R China.
EM jiangjuntcm2007@hotmail.com
FU National Natural Science Foundation of China [81703773]; Natural Science
   Foundation of Jiangsu Province [BK20170560]; China Postdoctoral Science
   Foundation [2016M590424, 2018T110461]; Jiangsu Postdoctoral Science
   Foundation [1601184C]
FX This work was supported by the National Natural Science Foundation of
   China (no. 81703773), Natural Science Foundation of Jiangsu Province
   (no. BK20170560), China Postdoctoral Science Foundation (nos.
   2016M590424 and 2018T110461), and Jiangsu Postdoctoral Science
   Foundation (no. 1601184C). The authors gratefully acknowledge the
   dedicated efforts of the study investigators and staff at the clinical
   study centers and recognize the participants for their commitment to
   this trial.
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NR 61
TC 7
Z9 7
U1 1
U2 26
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1741-427X
EI 1741-4288
J9 EVID-BASED COMPL ALT
JI Evid.-based Complement Altern. Med.
PY 2018
VL 2018
AR 1741924
DI 10.1155/2018/1741924
PG 13
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA GS4QW
UT WOS:000443635000001
PM 30210570
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Park, CH
   Kim, JH
   Lee, EB
   Hur, W
   Kwon, OJ
   Park, HJ
   Yoon, SK
AF Park, Chung-Hwa
   Kim, Jung-Hee
   Lee, Eun Byul
   Hur, Wonhee
   Kwon, Oh-Joo
   Park, Hyoung-Jin
   Yoon, Seung Kew
TI Aronia melanocarpa Extract Ameliorates Hepatic Lipid Metabolism
   through PPARγ2 Downregulation
SO PLOS ONE
LA English
DT Article
ID FATTY LIVER-DISEASE; PPAR-GAMMA; NONALCOHOLIC STEATOHEPATITIS;
   DIABETES-MELLITUS; OXIDATIVE STRESS; OBESE MICE; LEPTIN; JUICE;
   ACCUMULATION; LIPOGENESIS
AB Nonalcoholic fatty liver disease (NAFLD) is a hepatic manifestation of metabolic syndrome. Studies have demonstrated that anthocyanin-rich foods may improve hyperlipidemia and ameliorate hepatic steatosis. Here, effects of Aronia melanocarpa (AM), known to be rich of anthocyanins, on hepatic lipid metabolism and adipogenic genes were determined. AM was treated to C57BL/6N mice fed with high fat diet (HFD) or to FL83B cells treated with free fatty acid (FFA). Changes in levels of lipids, enzymes and hormones were observed, and expressions of adipogenic genes involved in hepatic lipid metabolism were detected by PCR, Western blotting and luciferase assay. In mice, AM significantly reduced the body and liver weight, lipid accumulation in the liver, and levels of biochemical markers such as fatty acid synthase, hepatic triglyceride and leptin. Serum transaminases, indicators for hepatocyte injury, were also suppressed, while superoxide dismutase activity and liver antioxidant capacity were significantly increased. In FL83B cells, AM significantly reduced FFA-induced lipid droplet accumulation. Protein synthesis of an adipogenic transcription factor, peroxisome proliferator-activated receptor gamma 2 (PPAR gamma 2) was inhibited in vivo. Furthermore, transcriptional activity of PPAR gamma 2 was down-regulated in vitro, and mRNA expression of PPAR gamma 2 and its downstream target genes, adipocyte protein 2 and lipoprotein lipase were down-regulated by AM both in vitro and in vivo. These results show beneficial effects of AM against hepatic lipid accumulation through the inhibition of PPAR gamma 2 expression along with improvements in body weight, liver functions, lipid profiles and antioxidant capacity suggesting the potential therapeutic efficacy of AM on NAFLD.
C1 [Park, Chung-Hwa; Yoon, Seung Kew] Catholic Univ Korea, Coll Med, Dept Internal Med, Div Gastroenterol & Hepatol, Seoul, South Korea.
   [Park, Chung-Hwa; Kim, Jung-Hee; Lee, Eun Byul; Hur, Wonhee; Yoon, Seung Kew] Catholic Univ Korea, CULRC, Seoul, South Korea.
   [Kim, Jung-Hee; Lee, Eun Byul; Hur, Wonhee; Yoon, Seung Kew] Catholic Univ Korea, WHO Collaborating Ctr Viral Hepatitis, Seoul, South Korea.
   [Kwon, Oh-Joo] Catholic Univ Korea, Coll Med, Dept Med Biochem, Seoul, South Korea.
   [Park, Hyoung-Jin] MushMed Co LTD, Chuncheon Si, Gangwon Do, South Korea.
C3 Catholic University of Korea; Catholic University of Korea; Catholic
   University of Korea; Catholic University of Korea
RP Yoon, SK (corresponding author), Catholic Univ Korea, Coll Med, Dept Internal Med, Div Gastroenterol & Hepatol, Seoul, South Korea.
EM yoonsk@catholic.ac.kr
RI Kim, Jung Hee/GYU-4816-2022
OI Park, Chung-Hwa/0000-0001-5992-6156
FU Basic Science Research Program through the National Research Foundation
   of Korea (NRF) - Ministry of Education, Science and Technology
   [2015R1A2A1A15052783]; MushMed Co., LTD
FX This study was supported by Basic Science Research Program through the
   National Research Foundation of Korea (NRF) funded by the Ministry of
   Education, Science and Technology (2015R1A2A1A15052783). There was no
   additional external funding received for this study. MushMed Co., LTD.
   provided support in the form of salaries for HJP, but did not have any
   additional role in the study design, data collection and analysis,
   decision to publish, or preparation of the manuscript. The specific role
   of this author is articulated in the 'author contributions' section, and
   this does not alter our adherence to PLOS ONE policies on sharing data
   and materials.
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NR 53
TC 38
Z9 41
U1 0
U2 24
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JAN 12
PY 2017
VL 12
IS 1
AR e0169685
DI 10.1371/journal.pone.0169685
PG 22
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA EH7JQ
UT WOS:000391949500064
PM 28081181
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Zhang, Y
   Zhao, YF
   Zhang, TY
   Xu, Q
   He, J
AF Zhang, Yuan
   Zhao, Yanfang
   Zhang, Tianyi
   Xu, Qin
   He, Jia
TI Cross-sectional associations between serum bilirubin and dyslipidemia in
   a population-based sample of Chinese
SO INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
LA English
DT Article
DE Total bilirubin; Chinese; dyslipidemia; oxidative stress
ID CARDIOVASCULAR RISK-FACTORS; ISCHEMIC-HEART-DISEASE; C-REACTIVE PROTEIN;
   METABOLIC SYNDROME; GILBERTS-SYNDROME; NATIONAL-HEALTH; LEVEL; ADULTS
AB The associations between serum bilirubin (TB) and dyslipidemia were observed in some studies. However, these associations were controversial and such studies were few in China. Our study aimed to evaluate the cross-sectional relationships between TB and dyslipidemia in a representative general Chinese population. A total of 2464 participants aged 18-80 years were selected in Shanghai, using a randomized, stratified, multi-stage sampling method, and were asked to provide blood samples to test for TB and other indexes, quantiles were used to evaluate the distribution of TB and odds ratios (ORs) of prevalent dyslipidemia for TB were estimated by logistic model to reveal the association between TB levels and dyslipidemia. Median TB level was 11.3 mu mol/L for all the participants (12.3 mu mol/L for males and 10.6 mu mol/L for females). In males, there were significant inverse associations between TB and both prevalent hypertriglyceridemia and hypo-HDL cholesterolemia in both models (all P<0.05). In females, such association was just observed in the prevalence of hypertriglyceridemia in both models (all P<0.05). The baseline TB levels were significantly correlated with total cholesterol, triglyceride, HDL cholesterol and LDL cholesterol in male. In females, the baseline TB levels were only significantly correlated with triglyceride and HDL cholesterol. The TB level of Chinese population is close to other Asian populations but much higher than the western populations. The increasing TB level was significantly associated with decreasing prevalent hypertriglyceridemia both in males and females, and with decreasing prevalent hypo-HDL cholesterolemia just in males.
C1 [Zhang, Yuan; Zhao, Yanfang; Zhang, Tianyi; Xu, Qin; He, Jia] Second Mil Med Univ, Dept Hlth Stat, 800 Xiangyin Rd, Shanghai 200433, Peoples R China.
C3 Naval Medical University
RP He, J (corresponding author), Second Mil Med Univ, Dept Hlth Stat, 800 Xiangyin Rd, Shanghai 200433, Peoples R China.
EM hejia63@yeah.net
RI Zhang, Tianyi/AAJ-6909-2020; he, jia/LBH-8808-2024
OI He, Jia/0000-0002-2338-9501
FU key discipline for construction of evidence-based public health in
   Shanghai [12GWZX0602]; Fourth Round of Three-year Action Plan on Public
   Health Discipline and Talent Program: Evidence-based Public Health and
   Health Economics [15GWZK0901]; leading talents of science in Shanghai
   [022]; fund for youth in the Second Military Medical University of China
   [2012QN10]
FX This study was sponsored by a grant from the key discipline for
   construction of evidence-based public health in Shanghai (No.
   12GWZX0602), the Fourth Round of Three-year Action Plan on Public Health
   Discipline and Talent Program: Evidence-based Public Health and Health
   Economics (No. 15GWZK0901), the leading talents of science in Shanghai
   2010 (022) and the fund for youth in the Second Military Medical
   University of China (No. 2012QN10). We gratefully acknowledge Shanghai
   CDC, Hongkou CDC and Baoshan CDC for their assistance in designing the
   study, selecting participants and field work. We also thank the
   respondents who gave their time and effort to participate in the study.
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NR 39
TC 0
Z9 0
U1 0
U2 4
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 1940-5901
J9 INT J CLIN EXP MED
JI Int. J. Clin. Exp. Med.
PY 2016
VL 9
IS 2
BP 4291
EP 4299
PG 9
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA DK1EL
UT WOS:000374655200460
DA 2025-06-11
ER

PT J
AU Ahowesso, C
   Black, PN
   Saini, N
   Montefusco, D
   Chekal, J
   Malosh, C
   Lindsley, CW
   Stauffer, SR
   DiRusso, CC
AF Ahowesso, Constance
   Black, Paul N.
   Saini, Nipun
   Montefusco, David
   Chekal, Jessica
   Malosh, Chrysa
   Lindsley, Craig W.
   Stauffer, Shaun R.
   DiRusso, Concetta C.
TI Chemical inhibition of fatty acid absorption and cellular uptake limits
   lipotoxic cell death
SO BIOCHEMICAL PHARMACOLOGY
LA English
DT Article
DE FATP2 inhibitor; Lipotoxicity; Lipid droplet; Fatty acid transport
ID ACYL-COA SYNTHETASE; PROTEIN-1 FATP1 INHIBITORS; DIET-INDUCED OBESITY;
   LONG-TERM EXPOSURE; TRANSPORT PROTEIN; INSULIN-RESISTANCE; HEPATOCYTE
   LIPOAPOPTOSIS; VECTORIAL ACYLATION; METABOLIC SYNDROME;
   PANCREATIC-ISLETS
AB Chronic elevation of plasma free fatty acid (FFA) levels is commonly associated with obesity, type 2 diabetes, cardiovascular disease and some cancers. Experimental evidence indicates FFA and their metabolites contribute to disease development through lipotoxicity. Previously, we identified a specific fatty acid transport inhibitor CB16.2, a.k.a. Lipofermata, using high throughput screening methods. In this study, efficacy of transport inhibition was measured in four cell lines that are models for myocytes (mmC2C12), pancreatic beta-cells (rnINS-1E), intestinal epithelial cells (hsCaco-2), and hepatocytes (hsHepG2), as well as primary human adipocytes. The compound was effective in inhibiting uptake with IC(50)s between 3 and 6 mu M for all cell lines except human adipocytes (39 mu M). Inhibition was specific for long and very long chain fatty acids but had no effect on medium chain fatty acids (C6-C10), which are transported by passive diffusion. Derivatives of Lipofermata were evaluated to understand structural contributions to activity. Lipofermata prevented palmitate-mediated oxidative stress, induction of BiP and CHOP, and cell death in a dose-dependent manner in hsHepG2 and rnINS-1E cells, suggesting it will prevent induction of fatty acid-mediated cell death pathways and lipotoxic disease by channeling excess fatty acids to adipose tissue and away from liver and pancreas. Importantly, mice dosed orally with Lipofermata were not able to absorb C-13-oleate demonstrating utility as an inhibitor of fatty acid absorption from the gut. (C) 2015 Elsevier Inc. All rights reserved.
C1 [Ahowesso, Constance; Black, Paul N.; Saini, Nipun; Montefusco, David; Chekal, Jessica; DiRusso, Concetta C.] Univ Nebraska, Dept Biochem, Lincoln, NE 68588 USA.
   [Malosh, Chrysa; Lindsley, Craig W.; Stauffer, Shaun R.] Vanderbilt Univ, Med Ctr, Dept Pharmacol, Nashville, TN 37232 USA.
   [Malosh, Chrysa; Lindsley, Craig W.; Stauffer, Shaun R.] Vanderbilt Specialized Chem Ctr Probe Dev MLPCN, Nashville, TN 37232 USA.
   [Lindsley, Craig W.; Stauffer, Shaun R.] Vanderbilt Univ, Dept Chem, Nashville, TN 37232 USA.
C3 University of Nebraska System; University of Nebraska Lincoln;
   Vanderbilt University; Vanderbilt University; Vanderbilt University
RP DiRusso, CC (corresponding author), Univ Nebraska, Dept Biochem, N241 Beadle Ctr, Lincoln, NE 68588 USA.
EM cdirusso2@unl.edu
RI Lindsley, Craig/IZD-8302-2023; DiRusso, Concetta/M-1884-2014
OI SAINI, NIPUN/0000-0001-6775-3486; DiRusso, Concetta/0000-0001-7388-9152;
   Black, Paul/0000-0002-6272-6881
FU National Institutes of Health [DK071076, GM056840]; Vanderbilt
   University Specialized Chemistry Center within the Molecular Libraries
   Probe Production Center Network (MLPCN) [U54MH084659]
FX This work was supported by National Institutes of Health grants DK071076
   and GM056840 (CCD and PNB). Probe development was supported by
   U54MH084659 at the Vanderbilt University Specialized Chemistry Center
   within the Molecular Libraries Probe Production Center Network (MLPCN).
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NR 71
TC 45
Z9 52
U1 0
U2 38
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0006-2952
EI 1873-2968
J9 BIOCHEM PHARMACOL
JI Biochem. Pharmacol.
PD NOV 1
PY 2015
VL 98
IS 1
BP 167
EP 181
DI 10.1016/j.bcp.2015.09.004
PG 15
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA CU2LG
UT WOS:000363354400015
PM 26394026
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Tsai, MS
   Chen, HP
   Hung, CM
   Lee, PH
   Lin, CL
   Kao, CH
AF Tsai, Ming-Shian
   Chen, Hsin-Pao
   Hung, Chao-Ming
   Lee, Po-Huang
   Lin, Cheng-Li
   Kao, Chia-Hung
TI Hospitalization for Inflammatory Bowel Disease is Associated with
   Increased Risk of Breast Cancer: A Nationwide Cohort Study of an Asian
   Population
SO ANNALS OF SURGICAL ONCOLOGY
LA English
DT Article
ID NONSTEROIDAL ANTIINFLAMMATORY DRUGS; METABOLIC SYNDROME; OXIDATIVE
   STRESS; IMMUNOSUPPRESSION; EPIDEMIOLOGY; COLITIS; LIFE
AB To learn whether women with inflammatory bowel disease (IBD) exhibit a higher risk of breast cancer.
   We identified 4,856 women with IBD symptoms from 1998 to 2008 and 19,424 control patients without the disorder, frequency matched by age, sex, and admission year. Both cohorts were followed-up until the end of 2010 to estimate the risk of breast cancer.
   Overall, the incidence of breast cancer was similar in the IBD and control cohorts (1.31 vs. 1.25 per 1,000 person-years). The adjusted hazard ratio of breast cancer was 0.95 (95 % confidence interval 0.66-1.36) for the IBD patients. Further analysis revealed that neither Crohn disease nor ulcerative colitis was associated with the risk of developing breast cancer in women. The age-specific analysis indicated that the incidence of breast cancer was highest in the 45- to 65-year-old age group in both cohorts. The incidence of breast cancer was significantly increased in patients who required hospitalization twice or more per year, compared with the control cohort (adjusted hazard ratio 8.45; 95 % confidence interval 4.64-15.4). Moreover, age-specific analysis showed that patients aged less than 65 years old (a parts per thousand currency sign44 or 45-65 years of age) exhibited a strong association between IBD hospitalization and breast cancer risk.
   The risk of breast cancer was positively proportional to the frequency of admission for IBD. Therefore, careful surveillance of breast cancer should be sought for female IBD patients with 2 or more annual hospitalizations.
C1 [Tsai, Ming-Shian; Hung, Chao-Ming; Lee, Po-Huang] E Da Hosp, Dept Gen Surg, Kaohsiung, Taiwan.
   [Tsai, Ming-Shian; Chen, Hsin-Pao; Hung, Chao-Ming; Lee, Po-Huang] I Shou Univ, Kaohsiung, Taiwan.
   [Chen, Hsin-Pao] E Da Hosp, Dept Colorectal Surg, Kaohsiung, Taiwan.
   [Lin, Cheng-Li] China Med Univ Hosp, Management Off Hlth Data, Taichung, Taiwan.
   [Lin, Cheng-Li] China Med Univ, Coll Med, Taichung, Taiwan.
   [Kao, Chia-Hung] China Med Univ, Coll Med, Grad Inst Clin Med Sci, Taichung, Taiwan.
   [Kao, Chia-Hung] China Med Univ, Coll Med, Sch Med, Taichung, Taiwan.
   [Kao, Chia-Hung] China Med Univ Hosp, Dept Nucl Med, Taichung, Taiwan.
   [Kao, Chia-Hung] China Med Univ Hosp, PET Ctr, Taichung, Taiwan.
C3 E-Da Hospital; I Shou University; E-Da Hospital; China Medical
   University Taiwan; China Medical University Hospital - Taiwan; China
   Medical University Taiwan; China Medical University Taiwan; China
   Medical University Taiwan; China Medical University Taiwan; China
   Medical University Hospital - Taiwan; China Medical University Taiwan;
   China Medical University Hospital - Taiwan
RP Kao, CH (corresponding author), China Med Univ, Coll Med, Grad Inst Clin Med Sci, Taichung, Taiwan.
EM d10040@mail.cmuh.org.tw
RI LIN, Changqing/G-7903-2018; Chen, Hsieh-Chih/L-6941-2019; Lin, Justin
   Chun-Te/AAT-7240-2021; LEE, HYUN/ABC-6119-2021
OI LEE, PO-HUANG/0000-0001-5831-035X; Lin, Cheng-Li/0000-0001-9926-3668
FU China Medical University [CMU102-BC-2]; Taiwan Ministry of Health and
   Welfare Clinical Trial and Research Center of Excellence
   [MOHW103-TDU-B-212-113002]; China Medical University Hospital Cancer
   Research Center of Excellence, Taiwan [MOHW103-TD-B-111-03];
   International Research-Intensive Centers of Excellence in Taiwan
   [NSC101-2911-I-002-303]
FX This study was partially supported by study projects of China Medical
   University (CMU102-BC-2); Taiwan Ministry of Health and Welfare Clinical
   Trial and Research Center of Excellence (MOHW103-TDU-B-212-113002),
   Health and welfare surcharge of tobacco products, China Medical
   University Hospital Cancer Research Center of Excellence
   (MOHW103-TD-B-111-03, Taiwan); and the International Research-Intensive
   Centers of Excellence in Taiwan (NSC101-2911-I-002-303). The funders had
   no role in study design, data collection and analysis, decision to
   publish, or preparation of the manuscript.
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NR 45
TC 9
Z9 9
U1 0
U2 2
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1068-9265
EI 1534-4681
J9 ANN SURG ONCOL
JI Ann. Surg. Oncol.
PD JUN
PY 2015
VL 22
IS 6
BP 1996
EP 2002
DI 10.1245/s10434-014-4198-0
PG 7
WC Oncology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Surgery
GA CH7ON
UT WOS:000354226600035
PM 25354573
DA 2025-06-11
ER

PT J
AU Lee, SW
   Youm, Y
   Kim, CO
   Lee, WJ
   Choi, W
   Chu, SH
   Park, YR
   Kim, HC
AF Lee, Seung Won
   Youm, Yoosik
   Kim, Chang Oh
   Lee, Won Joon
   Choi, Wungrak
   Chu, Sang Hui
   Park, Yeong-Ran
   Kim, Hyeon Chang
TI Association between skeletal muscle mass and radial augmentation index
   in an elderly Korean population
SO ARCHIVES OF GERONTOLOGY AND GERIATRICS
LA English
DT Article
DE Sarcopenia; Muscle mass; Arterial stiffness; Augmentation index;
   Elderly; Korea
ID ARTERIAL STIFFNESS; SARCOPENIC-OBESITY; METABOLIC SYNDROME; THIGH
   MUSCLE; INSULIN-RESISTANCE; OXIDATIVE STRESS; WAVE REFLECTIONS; PULSE
   PRESSURE; STRENGTH; HEALTH
AB Increasing evidence supports the importance of maintaining skeletal muscle mass for cardiovascular health. However, there is limited data on the relationship between skeletal muscle mass and arterial stiffness targeting an elderly population. Thus, we investigated the association between skeletal muscle mass and arterial stiffness in an elderly Korean population. This study used data from the Korean Social Life, Health and Aging Project which started in 2011. In this cross-sectional study, 180 men (mean age 71.7) and 247 women (mean age 70.9) were included. Arm and leg muscle masses were measured by bioelectrical impedance analysis. Radial augmentation index, a noninvasive measure of arterial stiffness, was assessed by radial pulse wave analysis. The relationship between skeletal muscle mass and augmentation index was investigated by multiple linear regression analysis. In men, limb muscle mass was significantly and inversely associated with augmentation index (beta = -1.07% per 1 kg muscle mass, p < 0.001) when adjusted for age. This inverse association remained after additional adjustment for body mass index, systolic blood pressure, total cholesterol, high-density lipoprotein-cholesterol, fasting glucose, insulin, smoking and alcohol intake (beta = -0.69%, p = 0.019). In women, the inverse association between limb muscle mass and augmentation index was less prominent (beta = 0.59%, p = 0.030), and the association disappeared when fully adjusted (beta = -0.32%, p = 0.304). However, limb muscle mass was not associated with resting blood pressure either in men or women. Our results suggest that decreased skeletal muscle mass may affect arterial wall elasticity. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
C1 [Lee, Seung Won] Yonsei Univ, Grad Sch, Dept Publ Hlth, Seoul 120752, South Korea.
   [Youm, Yoosik] Yonsei Univ, Coll Social Sci, Dept Sociol, Seoul 120752, South Korea.
   [Kim, Chang Oh] Yonsei Univ, Coll Med, Dept Internal Med, Seoul 120752, South Korea.
   [Lee, Won Joon; Kim, Hyeon Chang] Yonsei Univ, Coll Med, Dept Prevent Med, Seoul 120752, South Korea.
   [Choi, Wungrak] Yonsei Univ Hlth Syst, Severance Hosp, Seoul, South Korea.
   [Chu, Sang Hui] Yonsei Univ, Coll Nursing, Dept Clin Nursing Sci, Seoul 120752, South Korea.
   [Park, Yeong-Ran] Kangnam Univ, Div Silver Ind, Yongin, South Korea.
   [Lee, Seung Won; Kim, Hyeon Chang] Yonsei Univ, Coll Med, Cardiovasc & Metab Dis Etiol Res Ctr, Seoul 120752, South Korea.
C3 Yonsei University; Yonsei University; Yonsei University; Yonsei
   University Health System; Yonsei University; Yonsei University Health
   System; Yonsei University; Yonsei University Health System; Yonsei
   University; Yonsei University Health System; Kangnam University; Yonsei
   University; Yonsei University Health System
RP Kim, HC (corresponding author), Yonsei Univ, Coll Med, Dept Prevent Med, 50 Yonsei Ro, Seoul 120752, South Korea.
EM yoosik@yonsei.ac.kr; hckim@yuhs.ac
RI YOUM, YOOSIK/KBD-0367-2024; Kim, Chang/H-4759-2011; Kim, Hyeon
   Chang/F-8796-2019
OI Kim, Chang Oh/0000-0002-0773-5443; Choi, Wungrak/0000-0002-3015-2502;
   Youm, Yoosik/0000-0003-3822-5777; CHU, Sang Hui/0000-0001-6877-5599;
   Kim, Hyeon Chang/0000-0001-7867-1240
FU National Research Foundation of Korea - Korean Government
   [NRF-2011-330-B00137]
FX The KSHAP was supported by the National Research Foundation of Korea
   Grant funded by the Korean Government (NRF-2011-330-B00137).
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NR 54
TC 19
Z9 23
U1 0
U2 8
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0167-4943
EI 1872-6976
J9 ARCH GERONTOL GERIAT
JI Arch. Gerontol. Geriatr.
PD JUL-AUG
PY 2014
VL 59
IS 1
BP 49
EP 55
DI 10.1016/j.archger.2014.01.008
PG 7
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA AH9HR
UT WOS:000336453200008
PM 24836439
DA 2025-06-11
ER

PT J
AU Pashaj, A
   Yi, XH
   Xia, MN
   Canny, S
   Riethoven, JJM
   Moreau, R
AF Pashaj, Anjeza
   Yi, Xiaohua
   Xia, Mengna
   Canny, Stephanie
   Riethoven, Jean-Jack M.
   Moreau, Regis
TI Characterization of genome-wide transcriptional changes in liver and
   adipose tissues of ZDF (fa/fa) rats fed R-α-lipoic acid by
   next-generation sequencing
SO PHYSIOLOGICAL GENOMICS
LA English
DT Article
DE dyslipidemia; nonalcoholic fatty liver disease; nutritional genomics
ID SYMPTOMATIC DIABETIC POLYNEUROPATHY; CARDIOVASCULAR-DISEASE; INHIBIT
   TRANSCRIPTION; METABOLIC SYNDROME; ORAL TREATMENT; FATTY-ACIDS; GENE;
   PNPLA3; RISK; INFLAMMATION
AB We report on the characterization of lipogenic tissue transcriptional networks that support physiological responses of obese rats to a lipid-lowering bioactive food compound, R-alpha-lipoic acid (LA). Nine-week-old male Zucker diabetic fatty (fa/fa) rats were fed a chow diet supplemented with 3 g LA per kg diet or pair fed for 2 wk. At the end of the trial, high-quality RNA was extracted from the liver and epididymal fat and subjected to transcriptome analysis by RNA-Seq technology. Results showed a substantially higher number of differentially expressed genes [DEG, false discovery rate adjusted P <= 0.05 and absolute log(2) (fold change) >= 1] in the liver (110 genes) vs. epididymal fat (10 genes). Most epididymal fat DEG were also differentially expressed in liver and shared directionality of change. Gene Ontology (GO) analysis of these transcripts revealed significant enrichment of GO categories related to immune response, stress response, lipid metabolism, and carboxylic acid metabolic processes. Of interest, interferon-related genes involved in defense against microorganisms and innate immune response were induced by LA. Lipid metabolism-related transcript changes observed in LA-fed animals included downregulation of lipogenic genes (Pnpla3, Pnpla5, Elovl6, Acly, Gpam, and Aacs) and concomitant upregulation of short-, medium-, and long-chain fatty acid metabolic processes (Acot1, Acot2, Acsf2, and Crat). Transcriptional changes were accompanied by the lowering of abdominal adiposity and blood triacylglycerol levels. We conclude that LA dietary supplementation induces prominent gene expression changes in liver in support of significant improvement of whole-body lipid status.
C1 [Pashaj, Anjeza; Yi, Xiaohua; Xia, Mengna; Moreau, Regis] Univ Nebraska, Dept Nutr & Hlth Sci, Lincoln, NE 68583 USA.
   [Canny, Stephanie; Riethoven, Jean-Jack M.] Univ Nebraska, Beadle Ctr Biotechnol, Lincoln, NE 68583 USA.
C3 University of Nebraska System; University of Nebraska Lincoln;
   University of Nebraska System; University of Nebraska Lincoln
RP Moreau, R (corresponding author), Univ Nebraska, Dept Nutr & Hlth Sci, Lincoln, NE 68583 USA.
EM rmoreau2@unl.edu
RI yi, xiao/JHT-3220-2023
OI Moreau, Regis/0000-0003-0532-9887; Riethoven,
   Jean-Jack/0000-0002-2709-7880
FU University of Nebraska-Lincoln ARD Hatch Act; Nebraska Tobacco
   Settlement Funds; Layman Seed Award; University of Nebraska-Lincoln
   Faculty Seed Grant; Nebraska Research Initiative
FX This study was supported in part by University of Nebraska-Lincoln ARD
   Hatch Act, Nebraska Tobacco Settlement Funds, Layman Seed Award,
   University of Nebraska-Lincoln Faculty Seed Grant, and Nebraska Research
   Initiative.
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NR 52
TC 23
Z9 23
U1 0
U2 19
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 1094-8341
EI 1531-2267
J9 PHYSIOL GENOMICS
JI Physiol. Genomics
PD DEC
PY 2013
VL 45
IS 23
BP 1136
EP 1143
DI 10.1152/physiolgenomics.00138.2013
PG 8
WC Cell Biology; Genetics & Heredity; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Genetics & Heredity; Physiology
GA 267DB
UT WOS:000328075800002
PM 24104204
DA 2025-06-11
ER

PT J
AU Chen, AY
   Ha, JN
   DeLano, FA
   Schmid-Schönbein, GW
AF Chen, Angela Y.
   Ha, Jessica N.
   DeLano, Frank A.
   Schmid-Schoenbein, Geert W.
TI Receptor cleavage and P-select-independent reduction of leukocyte
   adhesion in the spontaneously hypertensive rat
SO JOURNAL OF LEUKOCYTE BIOLOGY
LA English
DT Article
DE glycoprotein ligand 1; matrix metalloproteinase; mesentery;
   extracellular receptor density; leukocyte rolling; MMP inhibitor
ID VON-WILLEBRAND-FACTOR; MATRIX-METALLOPROTEINASE INHIBITOR; FLUID SHEAR
   RESPONSE; PLATELET ACTIVATION; MMI270 CGS27023A; OXIDATIVE STRESS;
   INFLAMMATION; HISTAMINE; RISK; NEUTROPHILS
AB The SHR,a genetic model for hypertension and the metabolic syndrome, has attenuated leukocyte adhesion to the postcapillary endothelium by an unknown mechanism. Based on recent evidence of elevated levels of MMPs in plasma and on microvascular endothelium of the SHR with cleavage of several receptor types, we hypothesize that the reduced leukocyte-endothelial interaction is a result of enhanced proteolytic cleavage of P-selectin on the postcapillary endothelium and PSGL-1 on leukocytes. The attenuated rolling interactions of SHR leukocytes with the endothelium were restored by chronic treatment with a broad-spectrum MMP inhibitor (CGS) for 24 weeks. The SHR MMP levels, in plasma and mesentery, as well as the systolic blood pressure, decreased significantly with treatment. In the SHR mesentery, labeling of P-selectin in the post-capillary venules by immunohistochemistry demonstrated, on average, a 31% lower extracellular P-selectin density compared with the normotensive WKY. A significantly lower extracellular PSGL-1 density on the membranes of SHR neutrophils compared with the WKY also supported our hypothesis. In vivo stimulation of the mesenteric postcapillary venules with histamine demonstrated that the SHR had an attenuated response, as measured by leukocyte rolling velocity on the endothelium. The reduced P-selectin and PSGL-1 density, on SHR postcapillary endothelium and on SHR leukocytes, respectively, was restored significantly by chronic MMP inhibition. The impaired ability of SHR leukocytes to reduce rolling velocity upon inflammatory stimulation led to fewer firmly adhered leukocytes to the endothelium as a contributor to immune suppression. J. Leukoc. Biol. 92: 183-194; 2012.
C1 [Chen, Angela Y.; Ha, Jessica N.; DeLano, Frank A.; Schmid-Schoenbein, Geert W.] Univ Calif San Diego, Dept Bioengn, Inst Engn Med, La Jolla, CA 92093 USA.
C3 University of California System; University of California San Diego
RP Chen, AY (corresponding author), Univ Calif San Diego, Dept Bioengn, Inst Engn Med, 9500 Gilman Dr, La Jolla, CA 92093 USA.
EM ayc015@ucsd.edu
FU U.S. National Heart Lung and Blood Institute [HL-10881]
FX Support for this work was provided by the U.S. National Heart Lung and
   Blood Institute (Grant HL-10881).
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TC 12
Z9 13
U1 0
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0741-5400
EI 1938-3673
J9 J LEUKOCYTE BIOL
JI J. Leukoc. Biol.
PD JUL
PY 2012
VL 92
IS 1
BP 183
EP 194
DI 10.1189/jlb.0112010
PG 12
WC Cell Biology; Hematology; Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Hematology; Immunology
GA 966KS
UT WOS:000305837100020
PM 22566571
OA Green Published
DA 2025-06-11
ER

PT J
AU Kim, MK
   Baek, KH
   Song, KH
   Kang, MI
   Choi, JH
   Bae, JC
   Park, CY
   Lee, WY
   Oh, KW
AF Kim, Mee Kyoung
   Baek, Ki Hyun
   Song, Ki-Ho
   Kang, Moo Il
   Choi, Ji Hoon
   Bae, Ji Cheol
   Park, Cheol Young
   Lee, Won Young
   Oh, Ki Won
TI Increased Serum Ferritin Predicts the Development of Hypertension Among
   Middle-Aged Men
SO AMERICAN JOURNAL OF HYPERTENSION
LA English
DT Article
DE blood pressure; ferritin; hypertension; total iron-binding capacity
ID ERYTHROPOIETIN-INDUCED HYPERTENSION; OXIDATIVE STRESS; METABOLIC
   SYNDROME; INSULIN-RESISTANCE; BLOOD-PRESSURE; IRON; TRANSFERRIN; WOMEN;
   RISK; INFLAMMATION
AB BACKGROUND
   We aimed to examine the relationship between iron status and hypertension as few studies have addressed this.
   METHODS
   We analyzed the association between ferritin/total iron-binding capacity (TIBC) and the subsequent development of hypertension. A total of 8,580 men who visited the Health Promotion Center for a medical checkup in 2005 were followed-up after 4 years.
   RESULTS
   Of the 8,580 men who were not hypertensive at baseline, 818 were found to be hypertensive at the 4-year follow-up. Compared with those who remained normotensive, these hypertensive subjects had higher levels of ferritin and TIBC at baseline, but had no significant difference in iron levels. After adjustment for age and body mass index (BMI), the odds ratios (OR) was substantially higher for new hypertension (OR 1.54,95% confidence intervals (Cis) 1.26-1.88; P for trend < 0.001) in subjects with the highest ferritin quartiles compared with those in the lowest quartiles. The association of serum ferritin levels with the incidence of hypertension was unchanged after adjustment for baseline blood pressure (BP). Adjustment for insulin resistance as measured by the homeostasis model assessment and the presence of a fatty liver reduced the magnitude of the OR for hypertension (first quartile reference, fourth quartiles OR 1.24,95% Cl 1.01-1.53, P for trend = 0.012), but did not affect their statistical significance.
   CONCLUSION
   Serum ferritin, but not iron level, was a significant predictor of hypertension in middle-aged Korean men. Fatty liver disease and insulin resistance may be mediators of this high ferritin hypertension association.
C1 [Choi, Ji Hoon; Bae, Ji Cheol; Park, Cheol Young; Lee, Won Young; Oh, Ki Won] Sungkyunkwan Univ, Sch Med, Dept Internal Med, Kangbuk Samsung Hosp, Seoul, South Korea.
   [Kim, Mee Kyoung; Baek, Ki Hyun; Song, Ki-Ho; Kang, Moo Il] Catholic Univ Korea, Dept Internal Med, Seoul, South Korea.
C3 Sungkyunkwan University (SKKU); Samsung Medical Center; Catholic
   University of Korea
RP Oh, KW (corresponding author), Sungkyunkwan Univ, Sch Med, Dept Internal Med, Kangbuk Samsung Hosp, Seoul, South Korea.
EM okwendo@yahoo.co.kr
RI Hwang, You-Cheol/AAA-4616-2022; Kim, Dae/AAJ-7518-2021; Kim,
   Hyungduk/CAH-5630-2022; Park, Cheol-Young/C-6690-2018; LEE,
   WON-YOUNG/C-7249-2018
OI Park, Cheol-Young/0000-0002-9415-9965; LEE,
   WON-YOUNG/0000-0002-1082-7592
FU Samsung Biomedical Research Institute [SBRI C-B0-226-1, C-80-226-2]
FX This work was supported by the Samsung Biomedical Research Institute
   grant, #SBRI C-B0-226-1, C-80-226-2.
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NR 26
TC 48
Z9 52
U1 0
U2 10
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 0895-7061
J9 AM J HYPERTENS
JI Am. J. Hypertens.
PD APR
PY 2012
VL 25
IS 4
BP 492
EP 497
DI 10.1038/ajh.2011.241
PG 6
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 912OX
UT WOS:000301810600016
PM 22278211
OA Bronze
DA 2025-06-11
ER

PT J
AU Eller, NH
   Kristiansen, J
   Hansen, ÅM
AF Eller, Nanna Hurwitz
   Kristiansen, Jesper
   Hansen, Ase Marie
TI Long-term effects of psychosocial factors of home and work on biomarkers
   of stress
SO INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY
LA English
DT Article
DE HRV; Salivary cortisol; Prospective data; Work; Psychosocial factors;
   Demand control model; Effort Reward Model
ID HEART-RATE-VARIABILITY; AMBULATORY BLOOD-PRESSURE; EFFORT-REWARD
   IMBALANCE; INTIMA MEDIA THICKNESS; JOB STRAIN; CARDIOVASCULAR-DISEASE;
   SALIVARY CORTISOL; MYOCARDIAL-INFARCTION; METABOLIC SYNDROME;
   SEX-DIFFERENCES
AB Introduction: The current study analyzed the relationship between psychosocial factors measured at baseline and heart rate variability (HRV) and salivary cortisol measured at baseline and again, six years later.
   Methods: In 2002 and 2008, measurements of HRV and salivary cortisol at three time points were obtained from 70 healthy participants (48 women and 22 men). The associations between the psychosocial factors measured in 2002 and the dependent variables, HRV and salivary cortisol measured in 2002 and 2008, were examined using a series of repeated measures ANCOVAs. The dependent variables were as follows: the logarithmically transformed levels of total power (LnTP), high frequency power (LnHF), the ratio between low and high frequency power (LnLF/HF) and salivary cortisol (LnCortisol).
   Results: For women, high social status was associated with high LnTP, high LnHF, and low LnLF/HF. In work, lack of control was associated with low LnTP, and lack of support was associated with an increased LnLF/HF ratio. For men, high social status was associated with low LnTP, low LnHF and high LnCortisol. Greater number of hours spent doing housework was associated with both low LnLF/HF and low LnCortisol, whereas a large imbalance between effort and reward was associated with low LnTP and high LnCortisol.
   Conclusion: Despite the small sample size, this study demonstrated that psychosocial factors impact levels of activity in the allostatic systems. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Eller, Nanna Hurwitz] Bispebjerg Hosp, Dept Occupat & Environm Med, DK-2400 Copenhagen NV, Denmark.
   [Kristiansen, Jesper; Hansen, Ase Marie] Natl Res Ctr Working Environm, DK-2100 Copenhagen O, Denmark.
C3 University of Copenhagen; Copenhagen University Hospital; Bispebjerg
   Hospital; National Research Centre for the Working Environment
RP Eller, NH (corresponding author), Bispebjerg Hosp, Dept Occupat & Environm Med, Bispebjerg Bakke 23, DK-2400 Copenhagen NV, Denmark.
EM nell0005@bbh.regionh.dk
RI Hansen, Åse/AAJ-1043-2020; Kristiansen, Jesper/ACU-0794-2022; Eller,
   Nanna/B-3981-2009
OI Hansen, Ase Marie/0000-0002-4075-3918
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NR 63
TC 27
Z9 29
U1 0
U2 13
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0167-8760
EI 1872-7697
J9 INT J PSYCHOPHYSIOL
JI Int. J. Psychophysiol.
PD FEB
PY 2011
VL 79
IS 2
BP 195
EP 202
DI 10.1016/j.ijpsycho.2010.10.009
PG 8
WC Psychology, Biological; Neurosciences; Physiology; Psychology;
   Psychology, Experimental
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Neurosciences & Neurology; Physiology
GA 733WH
UT WOS:000288294700013
PM 21034783
DA 2025-06-11
ER

PT J
AU Ranieri, SC
   Fusco, S
   Panieri, E
   Labate, V
   Mele, M
   Tesori, V
   Ferrara, AM
   Maulucci, G
   De Spirito, M
   Martorana, GE
   Galeotti, T
   Pani, G
AF Ranieri, Sofia Chiatamone
   Fusco, Salvatore
   Panieri, Emiliano
   Labate, Valentina
   Mele, Marina
   Tesori, Valentina
   Ferrara, Anna Maria
   Maulucci, Giuseppe
   De Spirito, Marco
   Martorana, Giuseppe Ettore
   Galeotti, Tommaso
   Pani, Giovambattista
TI Mammalian life-span determinant p66<SUP>shcA</SUP> mediates
   obesity-induced insulin resistance
SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF
   AMERICA
LA English
DT Article
DE diabetes; longevity; mTOR/S6K; p66shc; nutrients
ID OXIDATIVE STRESS; GLUCOSE-INTOLERANCE; LONGEVITY; RECEPTOR; BETA;
   GENETICS; KINASE; CELLS; LINKS
AB Obesity and metabolic syndrome result from excess calorie intake and genetic predisposition and are mechanistically linked to type II diabetes and accelerated body aging; abnormal nutrient and insulin signaling participate in this pathologic process, yet the underlying molecular mechanisms are incompletely understood. Mice lacking the p66 kDa isoform of the Shc adaptor molecule live longer and are leaner than wild-type animals, suggesting that this molecule may have a role in metabolic derangement and premature senescence by overnutrition. We found that p66 deficiency exerts a modest but significant protective effect on fat accumulation and premature death in lep(Ob/Ob) mice, an established genetic model of obesity and insulin resistance; strikingly, however, p66 inactivation improved glucose tolerance in these animals, without affecting (hyper)insulinaemia and independent of body weight. Protection from insulin resistance was cell autonomous, because isolated p66KO preadipocytes were relatively resistant to insulin desensitization by free fatty acids in vitro. Biochemical studies revealed that p66shc promotes the signal-inhibitory phosphorylation of the major insulin transducer IRS-1, by bridging IRS-1 and the mTOR effector p70S6 kinase, a molecule previously linked to obesity-induced insulin resistance. Importantly, IRS-1 was strongly up-regulated in the adipose tissue of p66KO lep(Ob/Ob) mice, confirming that effects of p66 on tissue responsiveness to insulin are largely mediated by this molecule. Taken together, these findings identify p66shc as a major mediator of insulin resistance by excess nutrients, and by extension, as a potential molecular target against the spreading epidemic of obesity and type II diabetes.
C1 [Ranieri, Sofia Chiatamone; Fusco, Salvatore; Panieri, Emiliano; Labate, Valentina; Mele, Marina; Tesori, Valentina; Ferrara, Anna Maria; Galeotti, Tommaso; Pani, Giovambattista] Univ Cattolica Med Sch, Lab Cell Signaling, Inst Gen Pathol, I-00168 Rome, Italy.
   [Maulucci, Giuseppe; De Spirito, Marco] Univ Cattolica Med Sch, Inst Phys, I-00168 Rome, Italy.
   [Martorana, Giuseppe Ettore] Univ Cattolica Med Sch, Inst Biochem & Clin Biochem, I-00168 Rome, Italy.
RP Pani, G (corresponding author), Univ Cattolica Med Sch, Lab Cell Signaling, Inst Gen Pathol, I-00168 Rome, Italy.
EM gpani@rm.unicatt.it
RI De Spirito, Marco/U-3817-2019; Pani, Giovambattista/AAB-1446-2019;
   Panieri, Emiliano/AAB-9028-2021; Ferrara, Anna/AAN-2261-2020; mele,
   marina/C-7619-2014; Fusco, Salvatore/K-7867-2018; Maulucci,
   Giuseppe/C-7400-2009; De Spirito, Marco/C-5386-2008
OI Fusco, Salvatore/0000-0003-3294-0016; Maulucci,
   Giuseppe/0000-0002-2154-319X; De Spirito, Marco/0000-0003-4260-5107;
   Chiatamone Ranieri, Sofia/0000-0003-3151-5894; Panieri,
   Emiliano/0000-0001-7989-7145; Pani, Giovambattista/0000-0001-7133-8728
FU European Association for the Study of Diabetes; European Foundation for
   the Study of Diabetes/Glaxo Smith Kline; Italian Ministry of University
   and Research; Catholic University
FX We thank Prof. P. G. Pelicci and Dr. Marco Giorgio (European Institute
   of Oncology, Milan, Italy) for providing the p66shc KO mouse strain and
   the pBabe-p66shc expression construct, Drs. Fabio Martelli and Valeria
   Di Stefano (Molecular Cardiology Laboratory, Istituto di Ricovero e Cura
   a Carattere Scientifico-Policlinico San Donato, Milan, Italy) for the
   kind gift of the p66shc<SUP>qq</SUP> mutant, Drs. G. Nolan (University
   of Stanford, Palo Alto, CA), and Katherine Siminovitch (Mount Sinai
   Hospital, Toronto) for reagents, members of the laboratory for
   suggestions and experimental contributions, Egidio Stigliano for
   valuable technical support, and Drs. Renata Colavitti and Barbara
   Bedogni (Stanford University, Palo Alto, CA) for critically reading the
   manuscript. This work was supported by the European Association for the
   Study of Diabetes, European Foundation for the Study of Diabetes/Glaxo
   Smith Kline Programme for the Study of Metabolic Toxicity in Diabetes
   (G. P.) and the Italian Ministry of University and Research and Catholic
   University (MIUR ex 60% linea D1 to G.P.).
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NR 32
TC 86
Z9 93
U1 0
U2 22
PU NATL ACAD SCIENCES
PI WASHINGTON
PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA
SN 0027-8424
J9 P NATL ACAD SCI USA
JI Proc. Natl. Acad. Sci. U. S. A.
PD JUL 27
PY 2010
VL 107
IS 30
BP 13420
EP 13425
DI 10.1073/pnas.1008647107
PG 6
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 634RW
UT WOS:000280602800043
PM 20624962
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Hui, XY
   Li, HY
   Zhou, ZG
   Lam, KSL
   Xiao, Y
   Wu, DH
   Ding, K
   Wang, Y
   Vanhoutte, PM
   Xu, AM
AF Hui, Xiaoyan
   Li, Huiying
   Zhou, Zhiguang
   Lam, Karen S. L.
   Xiao, Yang
   Wu, Donghai
   Ding, Ke
   Wang, Yu
   Vanhoutte, Paul M.
   Xu, Aimin
TI Adipocyte Fatty Acid-binding Protein Modulates Inflammatory Responses in
   Macrophages through a Positive Feedback Loop Involving c-Jun
   NH2-terminal Kinases and Activator Protein-1
SO JOURNAL OF BIOLOGICAL CHEMISTRY
LA English
DT Article
ID ENDOPLASMIC-RETICULUM STRESS; HORMONE-SENSITIVE LIPASE; HUMAN THP-1
   MACROPHAGES; FOAM CELL-FORMATION; INSULIN-RESISTANCE;
   SIGNAL-TRANSDUCTION; METABOLIC SYNDROME; MAP KINASES; OBESITY; AP2
AB Adipocyte fatty acid-binding protein (A-FABP) has emerged as an important mediator of inflammation in macrophages. Macrophage-selective ablation of A-FABP alone is sufficient to prevent the development of high cholesterol diet-induced atherosclerosis in apoE-deficient mice. However, the precise mechanisms whereby A-FABP modulates inflammation remain elusive. Here, we report that A-FABP forms a finely tuned positive loop between JNK and activator protein-1 (AP-1) to exacerbate lipopolysaccharide (LPS)-induced inflammatory responses in macrophages. Real time PCR and luciferase reporter analysis showed that LPS induced A-FABP expression through transcriptional activation. This effect was mediated by JNK, which promoted the recruitment of c-Jun to a highly conserved AP-1 consensus binding motif located within the proximal region of the A-FABP promoter. LPS-induced transactivation of the A-FABP gene was diminished by either pharmacological inhibition of JNK or knocking down c-Jun or by mutating the AP-1 recognition site within the proximal region (-122 to -116 bp) of the A-FABP promoter. Conversely, the LPS-evoked phosphorylation of JNK, activation of AP-1, and production of pro-inflammatory cytokines were markedly attenuated by pharmacological or genetic suppression of A-FABP in macrophages. Furthermore, the LPS-induced elevation in A-FABP expression could also be prevented by the selective A-FABP inhibitor BMS309403. These findings support the notion that pharmacological inhibition of A-FABP represents a valid strategy for treating inflammation-related disorders such as atherosclerosis.
C1 [Hui, Xiaoyan; Lam, Karen S. L.; Xu, Aimin] Univ Hong Kong, Dept Med, Hong Kong, Hong Kong, Peoples R China.
   [Li, Huiying; Wang, Yu; Vanhoutte, Paul M.; Xu, Aimin] Univ Hong Kong, Dept Pharmacol & Pharm, Hong Kong, Hong Kong, Peoples R China.
   [Hui, Xiaoyan; Li, Huiying; Lam, Karen S. L.; Wang, Yu; Vanhoutte, Paul M.; Xu, Aimin] Univ Hong Kong, Res Ctr Heart Brain Hormone & Healthy Aging, Hong Kong, Hong Kong, Peoples R China.
   [Zhou, Zhiguang; Xiao, Yang] Cent S Univ, Xiangya Hosp 2, Inst Metab & Endocrinol, Metab Syndrome Res Ctr,Diabet Ctr, Changsha 410011, Peoples R China.
   [Wu, Donghai; Ding, Ke] Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Key Lab Regenerat Biol, Guangzhou 510663, Guangdong, Peoples R China.
C3 University of Hong Kong; University of Hong Kong; University of Hong
   Kong; Central South University; Chinese Academy of Sciences; Guangzhou
   Institute of Biomedicine & Health, CAS
RP Xu, AM (corresponding author), L8-40,New Lab Block,21 Sassoon Rd, Hong Kong, Hong Kong, Peoples R China.
EM amxu@hkucc.hku.hk
RI Wu, Donghai/H-4502-2017; Xu, Aimin/D-3291-2013; li, qing/JEF-9044-2023;
   Wang, Yu/B-4534-2009; Ding, Ke/B-3257-2010; Hui, Hannah
   Xiaoyan/M-5175-2019
OI Hui, Hannah Xiaoyan/0000-0002-7525-5812; ding, ke/0000-0001-8167-0476;
   wang, yu/0000-0001-8697-2940; Ding, Ke/0000-0001-9016-812X; Zhou,
   Zhiguang/0000-0002-0374-1838
FU Research Grants Council of Hong Kong; National Natural Science
   Foundation of China [N_HKU 735/08, 30831160518]; Collaborative Research
   Fund [HKU 2/07C]
FX This work was supported by Research Grants Council of Hong Kong, the
   National Natural Science Foundation of China Joint Research Scheme
   (Projects N_HKU 735/08 and 30831160518), and the Collaborative Research
   Fund (HKU 2/07C) from the Research Grants Council of Hong Kong.
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NR 48
TC 151
Z9 173
U1 3
U2 24
PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3996 USA
EI 1083-351X
J9 J BIOL CHEM
JI J. Biol. Chem.
PD APR 2
PY 2010
VL 285
IS 14
BP 10273
EP 10280
DI 10.1074/jbc.M109.097907
PG 8
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 578AC
UT WOS:000276264600011
PM 20145251
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Noland, RC
   Koves, TR
   Seiler, SE
   Lum, H
   Lust, RM
   Ilkayeva, O
   Stevens, RD
   Hegardt, FG
   Muoio, DM
AF Noland, Robert C.
   Koves, Timothy R.
   Seiler, Sarah E.
   Lum, Helen
   Lust, Robert M.
   Ilkayeva, Olga
   Stevens, Robert D.
   Hegardt, Fausto G.
   Muoio, Deborah M.
TI Carnitine Insufficiency Caused by Aging and Overnutrition Compromises
   Mitochondrial Performance and Metabolic Control
SO JOURNAL OF BIOLOGICAL CHEMISTRY
LA English
DT Article
ID ACETYL-L-CARNITINE; SKELETAL-MUSCLE MITOCHONDRIA; FATTY-ACID OXIDATION;
   INSULIN-RESISTANCE; ARTIFICIAL SELECTION; DIABETES-MELLITUS; GLUCOSE
   DISPOSAL; UP-REGULATION; BIOSYNTHESIS; DEFICIENCY
AB In addition to its essential role in permitting mitochondrial import and oxidation of long chain fatty acids, carnitine also functions as an acyl group acceptor that facilitates mitochondrial export of excess carbons in the form of acylcarnitines. Recent evidence suggests carnitine requirements increase under conditions of sustained metabolic stress. Accordingly, we hypothesized that carnitine insufficiency might contribute to mitochondrial dysfunction and obesity-related impairments in glucose tolerance. Consistent with this prediction whole body carnitine dimunition was identified as a common feature of insulin-resistant states such as advanced age, genetic diabetes, and diet-induced obesity. In rodents fed a lifelong (12 month) high fat diet, compromised carnitine status corresponded with increased skeletal muscle accumulation of acylcarnitine esters and diminished hepatic expression of carnitine biosynthetic genes. Diminished carnitine reserves in muscle of obese rats was accompanied by marked perturbations in mitochondrial fuel metabolism, including low rates of complete fatty acid oxidation, elevated incomplete beta-oxidation, and impaired substrate switching from fatty acid to pyruvate. These mitochondrial abnormalities were reversed by 8 weeks of oral carnitine supplementation, in concert with increased tissue efflux and urinary excretion of acetylcarnitine and improvement of whole body glucose tolerance. Acetylcarnitine is produced by the mitochondrial matrix enzyme, carnitine acetyltransferase (CrAT). A role for this enzyme in combating glucose intolerance was further supported by the finding that CrAT overexpression in primary human skeletal myocytes increased glucose uptake and attenuated lipid-induced suppression of glucose oxidation. These results implicate carnitine insufficiency and reduced CrAT activity as reversible components of the metabolic syndrome.
C1 [Noland, Robert C.; Koves, Timothy R.; Seiler, Sarah E.; Lum, Helen; Ilkayeva, Olga; Stevens, Robert D.; Muoio, Deborah M.] Duke Univ, Sarah W Stedman Nutr & Metab Ctr, Durham, NC 27710 USA.
   [Koves, Timothy R.; Muoio, Deborah M.] Duke Univ, Dept Med, Durham, NC 27710 USA.
   [Muoio, Deborah M.] Duke Univ, Dept Pharmacol & Canc Biol, Durham, NC 27710 USA.
   [Lust, Robert M.] E Carolina Univ, Dept Physiol, Greenville, NC 27834 USA.
   [Hegardt, Fausto G.] Univ Barcelona, Sch Pharm, Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr CB06 03, E-08028 Barcelona, Spain.
C3 Duke University; Duke University; Duke University; University of North
   Carolina; East Carolina University; Instituto de Salud Carlos III; CIBER
   - Centro de Investigacion Biomedica en Red; CIBEROBN; University of
   Barcelona
RP Muoio, DM (corresponding author), 4321 Med Pk Dr, Durham, NC 27704 USA.
EM Muoio@duke.edu
RI Muoio, Debbie/E-1147-2012; Koves, Tim/I-4806-2012; Noland,
   Robert/N-1982-2017
OI Muoio, Deborah/0000-0003-3760-9277; Noland, Robert/0000-0001-5543-3450;
   Koves, Timothy/0000-0001-8763-5866
FU National Institutes of Health [P30-AG028716, R01-AG028930,
   F32-DK080609]; American Diabetes Association; John A. Hartford Duke
   Center for Excellence Award
FX This work was supported, in whole or in part, by National Institutes of
   Health Grants P30-AG028716 and R01-AG028930 (to D. M. M.) and
   F32-DK080609 (to R. N.). This work was also supported by the American
   Diabetes Association (to D. M. M.) and a John A. Hartford Duke Center
   for Excellence Award (to T. R. K).
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NR 63
TC 265
Z9 287
U1 0
U2 28
PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3996 USA
EI 1083-351X
J9 J BIOL CHEM
JI J. Biol. Chem.
PD AUG 21
PY 2009
VL 284
IS 34
BP 22840
EP 22852
DI 10.1074/jbc.M109.032888
PG 13
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 483KG
UT WOS:000268963100038
PM 19553674
OA Green Published, hybrid
DA 2025-06-11
ER

PT S
AU Glimcher, LH
   Lee, AH
AF Glimcher, Laurie H.
   Lee, Ann-Hwee
BA Karsenty, G
BF Karsenty, G
TI From Sugar to Fat How the Transcription Factor XBP1 Regulates Hepatic
   Lipogenesis
SO INTEGRATIVE PHYSIOLOGY
SE Annals of the New York Academy of Sciences
LA English
DT Article; Book Chapter
DE XBP1; liver; lipogenesis; dyslipidemia; transcription; triglycerides;
   cholesterol
ID UNFOLDED PROTEIN RESPONSE; ELEMENT-BINDING-PROTEIN;
   ENDOPLASMIC-RETICULUM STRESS; TRIGLYCERIDE TRANSFER PROTEIN; PLASMA-CELL
   DIFFERENTIATION; NUCLEAR RECEPTOR LXR; MESSENGER-RNA; LIPID-SYNTHESIS;
   INSULIN-RESISTANCE; TRANSGENIC MICE
AB Lipogenesis occurs primarily in the liver, where dietary carbohydrates control the expression of key enzymes in glycolytic and lipogenic pathways. We have recently discovered that the transcription factor XBP1, best known as a key regulator of the unfolded protein response (UPR), is required for de novo fatty acid synthesis in the liver, a function unrelated to its role in the UPR. 1 XBP1 protein expression is induced in the liver by a high carbohydrate diet and directly controls the induction of critical genes involved in fatty acid synthesis. Specific deletion of XBP1 in adult liver using an inducible approach results in profound hypocholesterolemia and hypotriglyceridemia, which could be attributed to diminished production of lipids in the liver. Notably, this phenotype is not associated with fatty liver (hepatic steatosis) or significant compromise in protein secretion. XBP1 joins an already rich field of transcriptional regulatory proteins in the control of hepatic lipogenesis. Its function in lipogenesis appears to be highly significant as evidenced by the phenotype of the genetic mutant strain. A more complete understanding of the mechanisms by which XBP1 accelerates de novo fatty acid synthesis in the liver while preserving normal hepatic lipid composition is highly relevant to the treatment of diseases such as atherosclerosis and metabolic syndrome that are associated with dyslipidemia. Since excess fat accumulation in the liver could result from increased hepatic fatty acid synthesis, compounds that inhibit XBP1 activation may also be useful therapeutics for the treatment of human alcoholic liver disease (ALD) and nonalcoholic fatty liver disease (NAFLD), increasingly common causes of morbidity and mortality in the United States.
C1 [Glimcher, Laurie H.; Lee, Ann-Hwee] Harvard Univ, Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USA.
   [Glimcher, Laurie H.] Harvard Univ, Sch Med, Dept Med, Boston, MA USA.
C3 Harvard University; Harvard T.H. Chan School of Public Health; Harvard
   University; Harvard Medical School
RP Glimcher, LH (corresponding author), Harvard Univ, Sch Publ Hlth, Dept Immunol & Infect Dis, 665 Huntington Ave, Boston, MA 02115 USA.
EM lglimche@hsph.harvard.edu; ahlee@hsph.harvard.edu
FU NIAID NIH HHS [P01 AI056296, P01 AI56296, R01 AI032412, AI32412] Funding
   Source: Medline
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NR 65
TC 67
Z9 75
U1 2
U2 13
PU BLACKWELL SCIENCE PUBL
PI OXFORD
PA OSNEY MEAD, OXFORD OX2 0EL, ENGLAND
SN 0077-8923
J9 ANN NY ACAD SCI
JI Ann.NY Acad.Sci.
PY 2009
VL 1173
IS S1
BP E2
EP E9
DI 10.1111/j.1749-6632.2009.04956.x
PG 8
WC Multidisciplinary Sciences; Physiology
WE Book Citation Index – Science (BKCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics; Physiology
GA BZF77
UT WOS:000301432500002
PM 19751410
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Nettleton, JA
   Diez-Roux, A
   Jenny, NS
   Fitzpatrick, AL
   Jacobs, DR
AF Nettleton, Jennifer A.
   Diez-Roux, Ana
   Jenny, Nancy S.
   Fitzpatrick, Annette L.
   Jacobs, David R., Jr.
TI Dietary patterns, food groups, and telomere length in the Multi-Ethnic
   Study of Atherosclerosis (MESA)
SO AMERICAN JOURNAL OF CLINICAL NUTRITION
LA English
DT Article
ID ALL-CAUSE MORTALITY; IOWA WOMENS HEALTH; CARDIOVASCULAR-DISEASE RISK;
   TRANS-FATTY-ACIDS; ENDOTHELIAL DYSFUNCTION; INSULIN-RESISTANCE;
   OXIDATIVE STRESS; POSTMENOPAUSAL WOMEN; METABOLIC SYNDROME; PLASMA
   BIOMARKERS
AB Background: Telomere length reflects biological aging and may be influenced by environmental factors, including those that affect inflammatory processes.
   Objective: With data from 840 white, black, and Hispanic adults from the Multi-Ethnic Study of Atherosclerosis, we studied cross-sectional associations between telomere length and dietary patterns and foods and beverages that were associated with markers of inflammation.
   Design: Leukocyte telomere length was measured by quantitative polymerase chain reaction. Length was calculated as the amount of telomeric DNA (T) divided by the amount of a single-copy control DNA (S) (T/S ratio). Intake of whole grains, fruit and vegetables, low-fat dairy, nuts or seeds, nonfried fish, coffee, refined grains, fried foods, red meat, processed meat, and sugar-sweetened soda were computed with responses to a 120-item food-frequency questionnaire completed at baseline. Scores on 2 previously defined empirical dietary patterns were also computed for each participant.
   Results: After adjustment for age, other demographics, lifestyle factors, and intakes of other foods or beverages, only processed meat intake was associated with telomere length. For every 1 serving/d greater intake of processed meat, the T/S ratio was 0.07 smaller (beta +/- SE: -0.07 +/- 0.03, P = 0.006). Categorical analysis showed that participants consuming >= 1 serving of processed meat each week had 0.017 smaller T/S ratios than did nonconsumers. Other foods or beverages and the 2 dietary patterns were not associated with telomere length.
   Conclusions: Processed meat intake showed an expected inverse association with telomere length, but other diet features did not show their expected associations. Am J Clin Nutr 2008; 88: 1405-12.
C1 [Nettleton, Jennifer A.] Univ Texas Hlth Sci Ctr Houston, Div Epidemiol & Dis Control, Houston, TX 77005 USA.
   [Diez-Roux, Ana] Univ Michigan, Dept Epidemiol, Ann Arbor, MI 48109 USA.
   [Jenny, Nancy S.] Univ Vermont, Coll Med, Dept Pathol, Burlington, VT 05405 USA.
   [Fitzpatrick, Annette L.] Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA.
   [Jacobs, David R., Jr.] Univ Minnesota, Div Epidemiol & Community Hlth, Duluth, MN 55812 USA.
   [Jacobs, David R., Jr.] Univ Oslo, Dept Nutr, Oslo, Norway.
C3 University of Texas System; University of Texas Health Science Center
   Houston; University of Michigan System; University of Michigan;
   University of Vermont; University of Washington; University of
   Washington Seattle; University of Minnesota System; University of
   Minnesota Duluth; University of Oslo
RP Nettleton, JA (corresponding author), Univ Texas Hlth Sci Ctr Houston, Div Epidemiol & Dis Control, 1200 Herman Pressler,Suite E-641, Houston, TX 77005 USA.
EM jennifer.a.nettleton@uth.tmc.edu
RI Jacobs, David/G-5405-2011; Stefanadis, Christodoulos/ABH-2232-2020
OI Jacobs, David/0000-0002-7232-0543; Stefanadis,
   Christodoulos/0000-0001-5974-6454
FU National Heart, Lung, and Blood Institute [N01-HC-95159, N01-HC-95166,
   N01-HC-95169]; General Clinical Research Center [M01-RR00645]; National
   Center for Research Resources; MacArthur Foundation
FX Supported by the National Heart, Lung, and Blood Institute (contracts
   N01-HC-95159 through N01-HC-95166 and N01-HC-95169) and the General
   Clinical Research Center (grant M01-RR00645) from the National Center
   for Research Resources and by funding from the MacArthur Foundation.
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NR 61
TC 162
Z9 189
U1 1
U2 31
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0002-9165
EI 1938-3207
J9 AM J CLIN NUTR
JI Am. J. Clin. Nutr.
PD NOV 1
PY 2008
VL 88
IS 5
BP 1405
EP 1412
DI 10.3945/ajcn.2008.26429
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 370OD
UT WOS:000260770600030
PM 18996878
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Granata, F
   Vigna, L
   Pierro, ED
   Piontini, A
   Duca, L
   Luca, GD
   Fustinoni, S
   Fracanzani, AL
   Stefano, VD
   Graziadei, G
AF Granata, Francesca
   Vigna, Luisella
   Pierro, Elena Di
   Piontini, Alessandra
   Duca, Lorena
   Luca, Giacomo De
   Fustinoni, Silvia
   Fracanzani, Anna Ludovica
   Stefano, Valeria Di
   Graziadei, Giovanna
TI Nutrition and rare diseases: a case study of patients with acute
   intermittent porphyria (AIP)
SO NUTRITION & METABOLISM
LA English
DT Article
DE Acute intermittent porphyria; Glucose intake; Nutritional assessment;
   Metabolic disease; BIA
ID TREAT
AB Acute intermittent porphyria (AIP) is a rare metabolic disorder characterized by acute attacks often triggered by porphyrinogenic drugs and a low-glucose diet. According to recent findings, chronic symptoms persist in AIP patients. To avoid the symptoms, patients often adopt preventive strategies such as increasing glucose intake, suggesting that nutrition is a crucial aspect of disease management. Given the strong connection between AIP and glucose, we assessed anthropometric data, biochemical data and nutritional evaluation, in 16 AIP females and hypothesized that an increase in glucose consumption may lead to an imbalance in nutrition and metabolism. The results indicated that 14 out of 16 patients consumed high levels of simple sugars and saturated fatty acids (SFA), leading to overweight conditions (BMI > 25) in 50% of patients. The bioelectrical impedance analysis (BIA) showed excess fat mass in 64% of patients aged 30-49 years and 40% of patients aged 51-70 years; these results were more accurate than those obtained using BMI alone. Excessive intake of simple sugars and SFA resulted in elevated blood LDL levels in 36% of younger patients and 80% of older patients. Although the dietary intake of HDL was low, its levels were above normal and positively correlated with age (r = 0.56, p = 0.02). Overhydration, indicated by an elevated ECW/TBW ratio, was positively correlated with cortisol levels (r = 0.67, p = 0.008), suggesting metabolic stress. To summarize, excessive consumption of simple sugars and SFA affects the body composition and biochemical markers of AIP patients, emphasizing the need for nutritional support to prevent metabolic syndrome and manage chronic symptoms.
C1 [Granata, Francesca; Pierro, Elena Di; Duca, Lorena; Fracanzani, Anna Ludovica; Stefano, Valeria Di; Graziadei, Giovanna] Fdn IRCCS CaGranda Osped Maggiore Policlin, Unit Med & Metab Dis, Milan, Italy.
   [Vigna, Luisella; Piontini, Alessandra] Fdn IRCCS CaGranda, Osped Maggiore Policlin, Obes & Work Ctr, Milan, Italy.
   [Luca, Giacomo De] Osped Guglielmo Saliceto, Intermediate Care Unit, Piacenza, Italy.
   [Fustinoni, Silvia] Univ Milan, Dept Clin Sci & Community Hlth, EPIGET Lab, Milan, Italy.
   [Fustinoni, Silvia] Fdn IRCCS CaGranda Osped Maggiore Policlin, Lab Environm & Occupat Toxicol, Milan, Italy.
   [Fracanzani, Anna Ludovica] Univ Milan, Dept Pathophysiol & Transplantat, I-20122 Milan, Italy.
C3 IRCCS Ca Granda Ospedale Maggiore Policlinico; IRCCS Ca Granda Ospedale
   Maggiore Policlinico; Guglielmo da Saliceto Hospital; University of
   Milan; IRCCS Ca Granda Ospedale Maggiore Policlinico; University of
   Milan
RP Granata, F (corresponding author), Fdn IRCCS CaGranda Osped Maggiore Policlin, Unit Med & Metab Dis, Milan, Italy.
EM francesca.granata@policlinico.mi.it; luisella.vigna@policlinico.mi.it;
   elena.dipierro@policlinico.mi.it; alessandra.piontini@policlinico.mi.it;
   lorena.duca@policlinico.mi.it; giacomodeluca29@gmail.com;
   Silvia.fustinoni@unimi.it; Anna.fracanzani@policlinico.mi.it;
   valeria.distefano@policlinico.mi.it; giovanna.grazadei@policlinico.mi.it
RI Granata, Francesca/ABO-3061-2022; Di Pierro, Elena/A-3157-2009;
   Giovanna, Graziadei/AAC-1722-2019; Fracanzani, Anna Ludovica/J-8986-2018
FU Italian Ministry of Health
FX The Italian Ministry of Health (RC-2023/2024) supported this work.
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PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1743-7075
J9 NUTR METAB
JI Nutr. Metab.
PD MAR 11
PY 2025
VL 22
IS 1
AR 20
DI 10.1186/s12986-025-00900-9
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA Z9C4C
UT WOS:001441796300003
PM 40069861
OA gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Maaliah, MS
   Haddadin, M
   Abdalla, S
AF Maaliah, Mai S.
   Haddadin, Malik
   Abdalla, Shtaywy
TI Hypolipidemic and Hypoglycemic Effects of Silybum marianum (L.)
   Gaertn.(Milk Thistle) Ethanol Seed Extract in Streptozotocin-induced
   Diabetes in Rats
SO PHARMACOGNOSY MAGAZINE
LA English
DT Article
DE Antiglycation; anti-hyperlipidemia; Diabetes mellitus; Malondialdehyde;
   Silybum marianum
ID INDUCED OXIDATIVE STRESS; MILK THISTLE; ANTIOXIDANT ACTIVITIES;
   ALPHA-AMYLASE; INHIBITION; BLOOD
AB Background: Metabolic syndrome (MS) is considered a challenging health problem worldwide. However, the search for alternative treatments to alleviate MS is lacking. Purpose: This study defines Silybum marianum (milk thistle) ethanol seed extract (SMESE) in terms of polyphenol and flavonoid content, antiglycation effect, alpha-amylase activity, and hypolipidemic and hypoglycemic effects in streptozotocin (STZ)-induced diabetic rats. Materials and Methods: S. marianum seeds were collected, ground, and extracted with 80% ethanol. The alpha-amylase inhibitory activities of 10, 30, and 100 mu g/mL SMESE were evaluated using spectrophotometric methods. The inhibitory activity of SMESE against advanced glycation end-product formation was evaluated using fluorescence spectrophotometry. In vivo, 48 Wistar male albino rats were used. Eight animals served as the normal control (group 1), and 40 rats were injected with 60 mg/kg STZ to induce diabetes. Diabetic rats were divided into five groups: diabetic control (group 2) and positive control that received the hypoglycemic reference drug metformin at 100 mg/kg (group 3). Groups 4, 5, and 6 were administered the seed extract orally at 30, 100, and 300 mg/kg, respectively. Body weight, serum glucose, lipid profile, and malondialdehyde (MDA) levels were measured weekly for five weeks after SMESE administration. Results: SMESE administration inhibited BSA glycation and alpha-amylase activity. In vivo, SMESE administration increased body weight (BW), decreased serum glucose levels, and reduced triglyceride, total cholesterol, low-density lipoprotein, very low-density lipoprotein, and MDA levels but increased high-density lipoprotein levels. Conclusion: Data indicate the beneficial hypoglycemic and antihyperlipidemic effects of SMESE, suggesting its potential use in controlling lipid metabolism.
C1 [Maaliah, Mai S.; Abdalla, Shtaywy] Univ Jordan, Sch Sci, Dept Biol Sci, Amman, Jordan.
   [Haddadin, Malik] Univ Jordan, Sch Agr, Dept Nutr & Food Sci, Amman, Jordan.
C3 University of Jordan; University of Jordan
RP Abdalla, S (corresponding author), Univ Jordan, Sch Sci, Dept Biol Sci, Amman 11942, Jordan.
EM shtaywy@ju.edu.jo
OI Abdalla, shtaywy/0000-0003-4532-276X
FU Deanship of Research, The University of Jordan [19/2020/882]
FX This research received a grant from the Deanship of Research, The
   University of Jordan (#19/2020/882, dated September 24, 2020)
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PU SAGE PUBLICATIONS INDIA  PVT LTD
PI NEW DELHI
PA B-1-I-1 MOHAN CO-OPERATIVE INDUSTRIAL AREA, MATHURA RD, POST BAG NO 7,
   NEW DELHI 110 044, INDIA
SN 0973-1296
EI 0976-4062
J9 PHARMACOGN MAG
JI Pharmacogn. Mag.
PD SEP
PY 2024
VL 20
IS 3
BP 841
EP 852
DI 10.1177/09731296241231104
EA FEB 2024
PG 12
WC Chemistry, Medicinal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA A5G1B
UT WOS:001176002700001
OA hybrid
DA 2025-06-11
ER

PT J
AU Sung, HK
   Murugathasan, M
   Abdul-Sater, AA
   Sweeney, G
AF Sung, Hye Kyoung
   Murugathasan, Mayoorey
   Abdul-Sater, Ali A.
   Sweeney, Gary
TI Autophagy deficiency exacerbates iron overload induced reactive oxygen
   species production and apoptotic cell death in skeletal muscle cells
SO CELL DEATH & DISEASE
LA English
DT Article
ID OXIDATIVE STRESS; LABILE IRON
AB Iron overload is associated with various pathological changes which contribute to metabolic syndrome, many of which have been proposed to occur via damaging tissue through an excessive amount of reactive oxygen species (ROS) production. In this study, we established a model of iron overload in L6 skeletal muscle cells and observed that iron enhanced cytochrome c release from depolarized mitochondria, assayed by immunofluorescent colocalization of cytochrome c with Tom20 and the use of JC-1, respectively. This subsequently elevated apoptosis, determined via use of a caspase-3/7 activatable fluorescent probe and western blotting for cleaved caspase-3. Using CellROX deep red and mBBr, we observed that iron increased generation of reactive oxygen species (ROS), and that pretreatment with the superoxide dismutase mimetic MnTBAP reduced ROS production and attenuated iron-induced intrinsic apoptosis and cell death. Furthermore, using MitoSox Red we observed that iron enhanced mROS and the mitochondria-targeted anti-oxidant SKQ1 reduced iron-induced ROS generation and cell death. Western blotting for LC3-II and P62 levels as well as immunofluorescent detection of autophagy flux with LC3B and P62 co-localization indicated that iron acutely (2-8 h) activated and later (12-24 h) attenuated autophagic flux. We used autophagy-deficient cell models generated by overexpressing a dominant-negative Atg5 mutant or CRISPR-mediated ATG7 knock out to test the functional significance of autophagy and observed that autophagy-deficiency exacerbated iron-induced ROS production and apoptosis. In conclusion, our study showed that high iron levels promoted ROS production, blunted the self-protective autophagy response and led to cell death in L6 skeletal muscle cells.
C1 [Sung, Hye Kyoung; Sweeney, Gary] York Univ, Dept Biol, Toronto, ON, Canada.
   [Murugathasan, Mayoorey; Abdul-Sater, Ali A.] York Univ, Sch Kinesiol & Hlth Sci, Toronto, ON, Canada.
C3 York University - Canada; York University - Canada
RP Sweeney, G (corresponding author), York Univ, Dept Biol, Toronto, ON, Canada.
EM gsweeney@yorku.ca
OI Abdul-Sater, Ali/0000-0002-0022-0930
FU Canada's International Development Research Centre (IDRC); Canadian
   Institutes of Health Research (CIHR); Canada Foundation for Innovation
   [JELF 2018-0327]; Ontario Research Fund-Research Innovation (ORF-RI);
   CIHR Fellowship; York University
FX This work was funded by funding from Canada's International Development
   Research Centre (IDRC) and Canadian Institutes of Health Research (CIHR)
   to GS. This research was also funded by Startup funds from York
   University and infrastructure grants from Canada Foundation for
   Innovation (JELF 2018-0327) and Ontario Research Fund-Research
   Innovation (ORF-RI) to A.A.A-S". HKS acknowledges support via a CIHR
   Fellowship. We thank Hadee Abdul Lone and Patricia Reboucas for
   technical assistance with flow cytometry and western blotting analysis,
   respectively, and Dr Dana Al Rijjal for proofreading the text.
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NR 42
TC 23
Z9 25
U1 2
U2 17
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 2041-4889
J9 CELL DEATH DIS
JI Cell Death Dis.
PD APR 7
PY 2023
VL 14
IS 4
AR 252
DI 10.1038/s41419-022-05484-3
PG 13
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA C8DS7
UT WOS:000964165800001
PM 37029101
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Liu, P
   Chen, Y
   Xiao, J
   Zhu, WH
   Yan, XM
   Chen, M
AF Liu, Peng
   Chen, Yao
   Xiao, Jing
   Zhu, Wenhui
   Yan, Xiaoming
   Chen, Ming
TI Protective effect of natural products in the metabolic-associated kidney
   diseases via regulating mitochondrial dysfunction
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Review
DE metabolic-associated kidney diseases; mitochondrial dysfunction (MD);
   natural products; diabetic nephropathy; obesity-related nephropathy;
   hypertensive kidney disease; gouty nephropathy
ID NLRP3 INFLAMMASOME ACTIVATION; OXIDATIVE STRESS; DIABETIC-NEPHROPATHY;
   THERAPEUTIC TARGET; MELATONIN; RATS; PODOCYTES; MECHANISM; FISSION;
   INJURY
AB Metabolic syndrome (MS) is a complex group of metabolic disorders syndrome with hypertension, hyperuricemia and disorders of glucose or lipid metabolism. As an important organ involved in metabolism, the kidney is inevitably attacked by various metabolic disorders, leading to abnormalities in kidney structure and function. Recently, an increasing number of studies have shown that mitochondrial dysfunction is actively involved in the development of metabolic-associated kidney diseases. Mitochondrial dysfunction can be used as a potential therapeutic strategy for the treatment of metabolic-associated kidney diseases. Many natural products have been widely used to improve the treatment of metabolic-associated kidney diseases by inhibiting mitochondrial dysfunction. In this paper, by searching several authoritative databases such as PubMed, Web of Science, Wiley Online Library, and Springer Link. We summarize the Natural Products Protect Against Metabolic-Associated Kidney Diseases by Regulating Mitochondrial Dysfunction. In this review, we sought to provide an overview of the mechanisms by which mitochondrial dysfunction impaired metabolic-associated kidney diseases, with particular attention to the role of mitochondrial dysfunction in diabetic nephropathy, gouty nephropathy, hypertensive kidney disease, and obesity-related nephropathy, and then the protective role of natural products in the kidney through inhibition of mitochondrial disorders, thus providing a systematic understanding of the targets of mitochondrial dysfunction in metabolic-associated kidney diseases, and finally a review of promising therapeutic targets and herbal candidates for metabolic-associated kidney diseases through inhibition of mitochondrial dysfunction.
C1 [Liu, Peng] Shunyi Hosp, Beijing Tradit Chinese Med Hosp, Beijing, Peoples R China.
   [Chen, Yao; Xiao, Jing; Zhu, Wenhui; Chen, Ming] Heilongjiang Acad Chinese Med Sci, Dept Med, Renal Div, Harbin, Peoples R China.
   [Yan, Xiaoming] Heilongjiang Acad Chinese Med Sci, Dept Med, Digest Div, Harbin, Peoples R China.
RP Chen, M (corresponding author), Heilongjiang Acad Chinese Med Sci, Dept Med, Renal Div, Harbin, Peoples R China.; Yan, XM (corresponding author), Heilongjiang Acad Chinese Med Sci, Dept Med, Digest Div, Harbin, Peoples R China.
EM yanxiaoming604@126.com; chenming.6410@126.com
RI Xiao, Jing/AAB-1015-2020; LIU, Peng/IUO-1992-2023; Yan,
   Xiaoming/C-1354-2014
FU Research Projects of the National Natural Science Foundation of China
   [81904174, 82274489]
FX Funding This review was supported by the Research Projects of the
   National Natural Science Foundation of China (No. 81904174 and
   82274489).
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NR 102
TC 6
Z9 6
U1 5
U2 30
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD JAN 12
PY 2023
VL 13
AR 1093397
DI 10.3389/fphar.2022.1093397
PG 13
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 8G3JB
UT WOS:000920242000001
PM 36712696
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Beydoun, HA
   Beydoun, MA
   Maldonado, A
   Fanelli-Kuczmarski, MT
   Weiss, J
   Evans, MK
   Zonderman, AB
AF Beydoun, Hind A.
   Beydoun, May A.
   Maldonado, Ana, I
   Fanelli-Kuczmarski, Marie T.
   Weiss, Jordan
   Evans, Michele K.
   Zonderman, Alan B.
TI Allostatic Load and Cognitive Function Among Urban Adults in the Healthy
   Aging in Neighborhoods of Diversity across the Life Span Study
SO JOURNAL OF ALZHEIMERS DISEASE
LA English
DT Article
DE Adults; allostatic load; cognitive function; health disparities;
   longitudinal study
ID METABOLIC SYNDROME; SOCIOECONOMIC-STATUS; SAS PROCEDURE; STRESS;
   ASSOCIATION; ADAPTATION; BRAIN; SAMPLE; RISK; RACE
AB Background: Cross-sectional studies have linked cognition to allostatic load (AL) which reflects multisystem dysregulation from life course exposure to stressors.
   Objective: To examine baseline and changes in AL and their relationships with 11 cognitive function test scores, while exploring health disparities according to sex and race.
   Methods: Longitudinal [Visit 1 (2004-2009) and Visit 2 (2009-2013)] data were analyzed from 2,223 Healthy Aging in Neighborhoods of Diversity across the Life Span participants. We calculated AL total score using cardiovascular, metabolic, and inflammatory risk indicators, and applied group-based trajectory modeling to define AL change.
   Results: Overall and stratum-specific relationships were evaluated using mixed-effects linear regression models that controlled for socio-demographic, lifestyle, and health characteristics. Baseline AL was significantly associated with higher log-transformed Part A Trail Making Test score [Loge (TRAILS A)] (beta = 0.020, p = 0.004) and increasing AL was associated with higher Benton Visual Retention Test score [BVRT] (beta = 0.35, p = 0.002) at baseline, in models that controlled for age, sex, race, poverty status, education, literacy, smoking, drug use, the 2010 healthy eating index and body mass index. Baseline AL and AL change were not related to change in cognitive function between visits. There were no statistically significant interaction effects by sex or race in fully-adjusted models.
   Conclusion: At baseline, ALwas associated withworse attention or executive functioning. IncreasingALwas associated with worse non-verbal memory or visuo-constructional abilities at baseline. AL was not related to change in cognitive function over time, and relationships did not vary by sex or race.
C1 [Beydoun, Hind A.] Ft Belvoir Community Hosp, Dept Res Programs, 9300 DeWitt Loop, Ft Belvoir, VA 22060 USA.
   [Beydoun, May A.; Fanelli-Kuczmarski, Marie T.; Evans, Michele K.; Zonderman, Alan B.] Natl Inst Aging Intramural Res Program, Lab Epidemiol & Populat Sci, Baltimore, MD USA.
   [Maldonado, Ana, I] Univ Maryland Baltimore Cty, Dept Psychol, Baltimore, MD USA.
   [Weiss, Jordan] Stanford Univ, Stanford Ctr Longev, Stanford, CA USA.
C3 National Institutes of Health (NIH) - USA; NIH National Institute on
   Aging (NIA); University System of Maryland; University of Maryland
   Baltimore County; Stanford University
RP Beydoun, HA (corresponding author), Ft Belvoir Community Hosp, Dept Res Programs, 9300 DeWitt Loop, Ft Belvoir, VA 22060 USA.
EM Hind.a.Baydoun.civ@health.mil
RI Evans, Michele/AAE-4776-2019; Maldonado, Ana/KHV-6431-2024; Zonderman,
   Alan/A-5807-2013
OI Maldonado, Ana/0000-0002-7247-3363
FU Intramural Research Program of the National Institute on Aging,
   NIA/NIH/IRP, Baltimore, Maryland
FX The manuscript was supported in part by the Intramural Research Program
   of the National Institute on Aging, NIA/NIH/IRP, Baltimore, Maryland.
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NR 42
TC 6
Z9 6
U1 2
U2 7
PU IOS PRESS
PI AMSTERDAM
PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS
SN 1387-2877
EI 1875-8908
J9 J ALZHEIMERS DIS
JI J. Alzheimers Dis.
PY 2023
VL 92
IS 2
BP 425
EP 443
DI 10.3233/JAD-220888
PG 19
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA A0HL3
UT WOS:000952023800004
PM 36776055
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Pereira, TA
   D'ancona, CAL
   Cândido, EC
   Achermann, APP
   Chaim, EA
AF Pereira, Thairo A.
   D'ancona, Carlos A. L.
   Candido, Elaine C.
   Achermann, Arnold P. P.
   Chaim, Elinton A.
TI Prevalence of LUTS and urodynamics results in obese women
SO NEUROUROLOGY AND URODYNAMICS
LA English
DT Article
DE LUTS (female); obesity; overactive bladder; urinary incontinence;
   urodynamics
ID URINARY-TRACT SYMPTOMS; OVERACTIVE BLADDER; METABOLIC SYNDROME; SEEKING
   BEHAVIOR; WEIGHT-LOSS; INCONTINENCE; PRESSURE; OVERWEIGHT
AB Introduction Obesity is a well-known risk factor for lower urinary tract disorders. Lifestyle plays an essential role in the etiology of the symptoms, negatively affecting self-esteem and quality of social, professional, and sexual life. Objectives To assess the prevalence of lower urinary tract symptoms and urodynamic patterns in obese women and to compare to nonobese volunteers. Methods Overactive bladder (OAB) questionaries (International Consultation on Incontinence Questionnaire [ICIQ]-OAB) and stress urinary incontinence (SUI) (ICIQ-short form) were applied to the participants. They underwent a physical exam and urodynamics except for the control group. Results A total of 109 women completed the protocol and 20 were in the control group. The average age was 43.0 years, and the average body mass index was 45.12 +/- 7.64 kg/m(2) and control was 44.5 years, and 29.95 +/- 5.08 kg/m(2). The OAB symptoms in the obese group were 31.20%, 55.95% higher than the control group (20.0%). The prevalence of SUI in the obese group was 20.20%, an increase of 34.53% compared with the control group (15.00%). The urodynamic study (UDS) showed that the morbidly obese women have a first sensation earlier than the obese or severely obese, as well as the first desire to void. The Valsalva leak point pressure of morbidly obese women was significantly higher than the others. Conclusion Among obese women, either the prevalence of SUI or OAB is significantly higher than the nonobese female population. Regarding UDS, the pattern is similar to the clinic diagnostic. The grade of obesity is directly associated with an impairment of the patient's cystometric capacity.
C1 [Pereira, Thairo A.; D'ancona, Carlos A. L.; Candido, Elaine C.; Achermann, Arnold P. P.; Chaim, Elinton A.] Univ Campinas UNICAMP, Div Urol, Dept Surg, Fac Med Sci, Campinas, Brazil.
C3 Universidade Estadual de Campinas
RP Pereira, TA (corresponding author), Univ Campinas UNICAMP, Div Urol, Dept Surg, Fac Med Sci, Campinas, Brazil.
EM thairopereira@gmail.com
RI Achermann, Arnold/T-2363-2019
OI Chaim, Elinton/0000-0001-9370-9518; D'Ancona, Carlos Arturo
   Levi/0000-0002-5821-0292; Alves Pereira, Thairo/0000-0002-0864-2898
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NR 29
TC 3
Z9 3
U1 1
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0733-2467
EI 1520-6777
J9 NEUROUROL URODYNAM
JI Neurourol. Urodyn.
PD JAN
PY 2022
VL 41
IS 1
BP 468
EP 474
DI 10.1002/nau.24852
EA DEC 2021
PG 7
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA YC1VC
UT WOS:000728520400001
PM 34888922
DA 2025-06-11
ER

PT J
AU Atwater, AQ
   Immergluck, LC
   Davidson, AJ
   Castanon-Cervantes, O
AF Atwater, Aisha Q.
   Immergluck, Lilly Cheng
   Davidson, Alec J.
   Castanon-Cervantes, Oscar
TI Shift Work Predicts Increases in Lipopolysaccharide-Binding Protein,
   Interleukin-10, and Leukocyte Counts in a Cross-Sectional Study of
   Healthy Volunteers Carrying Low-Grade Systemic Inflammation
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Article
DE shift work; low-grade systemic inflammation; leukocyte proliferation;
   lipopolysaccharide-binding protein; systemic endotoxemia
ID C-REACTIVE PROTEIN; CIRCADIAN MISALIGNMENT; METABOLIC SYNDROME;
   BLOOD-PRESSURE; CHRONIC STRESS; RISK; SLEEP; IMMUNE; CYTOKINES; CORTISOL
AB The disruption of inflammatory responses is a potential mechanism behind the harmful effects of shift work and is associated with increased risk of hypertension, stroke, obesity, diabetes, and cancer. These responses are linked to the proliferation of leukocytes in shift workers, suggesting a systemic signal as a potential mediator. The purpose of this study was to assess the relationship between systemic inflammation, leukocyte counts, and systemic endotoxemia in samples from a diverse cohort of day workers and shift workers. Participants (normothermic and normotensive) were healthy volunteers, non-smoking, and drug- and medication-free. The following outcomes were measured: C-reactive protein, TNF-alpha, IL-6, IL-1 beta, IL-10, leukocyte counts (monocytes, lymphocytes, and neutrophils), and lipopolysaccharide-binding protein (LBP). Risk factors that increase systemic inflammation, such as blood pressure, sleep loss, and cortisol, were also assessed. The results indicated that shift workers slept significantly less than day workers and had significantly increased concentrations of all of the cytokines measured as well as plasma cortisol. Regression models found that after controlling for covariates, shift-work exposure predicted the significant increase observed in IL-10, leukocyte counts, and LBP. Our results suggest that acute increases in low-grade systemic endotoxemia are unresolved during chronic shift-work exposure. This ongoing immune challenge may underlie the disrupted inflammatory responses characteristic of shift-work-related pathologies. Systemic endotoxemia may represent a novel target to investigate the early effects of exposure to shift-work schedules.
C1 [Atwater, Aisha Q.; Davidson, Alec J.; Castanon-Cervantes, Oscar] Morehouse Sch Med, Dept Neurobiol, Atlanta, GA 30310 USA.
   [Atwater, Aisha Q.; Davidson, Alec J.; Castanon-Cervantes, Oscar] Morehouse Sch Med, Neurosci Inst, Atlanta, GA 30310 USA.
   [Immergluck, Lilly Cheng] Morehouse Sch Med, Dept Microbiol Biochem & Immunol, Atlanta, GA 30310 USA.
   [Immergluck, Lilly Cheng] Morehouse Sch Med, Pediat Clin & Translat Res Unit, Atlanta, GA 30310 USA.
C3 Morehouse School of Medicine; Morehouse School of Medicine; Morehouse
   School of Medicine; Morehouse School of Medicine
RP Castanon-Cervantes, O (corresponding author), Morehouse Sch Med, Dept Neurobiol, Atlanta, GA 30310 USA.; Castanon-Cervantes, O (corresponding author), Morehouse Sch Med, Neurosci Inst, Atlanta, GA 30310 USA.
EM atwater_aisha@yahoo.com; limmergluck@msm.edu; adavidson@msm.edu;
   ocastanon-cervantes@msm.edu
OI CASTANON-CERVANTES, OSCAR/0000-0001-7238-4726; Davidson,
   Alec/0000-0003-4205-1968
FU National Institute of General Medical Sciences [SC2GM125493]; NIMHD
   [R25MD007589];  [SC1GM112567];  [R35GM136661];  [R21NS108197]
FX This research was funded by the National Institute of General Medical
   Sciences under award number SC2GM125493 to O.C.-C., by the NIMHD
   (R25MD007589) to Alexander Quarshie, and by the SC1GM112567,
   R35GM136661, and R21NS108197 to A.J.D.
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NR 91
TC 12
Z9 14
U1 1
U2 3
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD DEC
PY 2021
VL 18
IS 24
AR 13158
DI 10.3390/ijerph182413158
PG 16
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA 0G1ML
UT WOS:000777816700001
PM 34948768
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Fauste, E
   Panadero, MI
   Donis, C
   Otero, P
   Bocos, C
AF Fauste, Elena
   Panadero, Maria, I
   Donis, Cristina
   Otero, Paola
   Bocos, Carlos
TI Pregnancy Is Enough to Provoke Deleterious Effects in Descendants of
   Fructose-Fed Mothers and Their Fetuses
SO NUTRIENTS
LA English
DT Article
DE fructose; pregnancy; fetal programming; fetus; lipids; insulin; leptin
ID INSULIN-RESISTANCE; INDUCED DYSLIPIDEMIA; OXIDATIVE STRESS; MATERNAL
   OBESITY; GLUCOSE; LEPTIN; MECHANISMS; DISEASE; RATS; SUPPLEMENTATION
AB The role of fructose in the global obesity and metabolic syndrome epidemic is widely recognized. However, its consumption is allowed during pregnancy. We have previously demonstrated that maternal fructose intake in rats induces detrimental effects in fetuses. However, these effects only appeared in adult descendants after a re-exposure to fructose. Pregnancy is a physiological state that leads to profound changes in metabolism and hormone response. Therefore, we wanted to establish if pregnancy in the progeny of fructose-fed mothers was also able to provoke an unhealthy situation. Pregnant rats from fructose-fed mothers (10% w/v) subjected (FF) or not (FC) to a fructose supplementation were studied and compared to pregnant control rats (CC). An OGTT was performed on the 20th day of gestation, and they were sacrificed on the 21st day. Plasma and tissues from mothers and fetuses were analyzed. Although FF mothers showed higher AUC insulin values after OGTT in comparison to FC and CC rats, ISI was lower and leptinemia was higher in FC and FF rats than in the CC group. Accordingly, lipid accretion was observed both in liver and placenta in the FC and FF groups. Interestingly, fetuses from FC and FF mothers also showed the same profile observed in their mothers on lipid accumulation, leptinemia, and ISI. Moreover, hepatic lipid peroxidation was even more augmented in fetuses from FC dams than those of FF mothers. Maternal fructose intake produces in female progeny changes that alter their own pregnancy, leading to deleterious effects in their fetuses.</p>
C1 [Fauste, Elena; Panadero, Maria, I; Donis, Cristina; Otero, Paola; Bocos, Carlos] CEU Univ, Univ San Pablo CEU, Fac Farm, Madrid 28668, Spain.
C3 San Pablo CEU University
RP Bocos, C (corresponding author), CEU Univ, Univ San Pablo CEU, Fac Farm, Madrid 28668, Spain.
EM ele.fauste.ce@ceindo.ceu.es; ipanade@ceu.es; cristinadonis9@gmail.com;
   paotero@ceu.es; carbocos@ceu.es
RI Otero, Paola/H-9150-2015; Fauste, Elena/AAT-8282-2020; Donis,
   Cristina/ABF-9806-2020; Panadero, Maria I./L-4262-2017; BOCOS,
   CARLOS/B-8460-2015
OI Panadero, Maria I./0000-0003-0459-3539; Donis Rodriguez,
   Cristina/0000-0003-2558-9539; Fauste, Elena/0000-0002-5783-3092; BOCOS,
   CARLOS/0000-0003-0364-5958
FU Ministerio de Ciencia, Innovacion y Universidades (MICINN)
   [SAF2017-89537-R, PID2020-118054RB-I00]; European Union FEDER funds; FPU
   fellowship from MICINN
FX This work was supported by grants from the Ministerio de Ciencia,
   Innovacion y Universidades (MICINN) (SAF2017-89537-R and
   PID2020-118054RB-I00) and European Union FEDER funds. Elena Fauste is
   supported with a FPU fellowship from MICINN.
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NR 54
TC 4
Z9 5
U1 0
U2 5
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD OCT
PY 2021
VL 13
IS 10
AR 3667
DI 10.3390/nu13103667
PG 17
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA WS9TW
UT WOS:000715519200001
PM 34684668
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Wang, XK
   Wu, TS
   Ma, HY
   Huang, XL
   Huang, KY
   Ye, CX
   Zhu, SP
AF Wang, Xiaokang
   Wu, Tiesong
   Ma, Hongyan
   Huang, Xiaoling
   Huang, Kaiyuan
   Ye, Chunxiao
   Zhu, Shiping
TI VX-765 ameliorates inflammation and extracellular matrix accumulation by
   inhibiting the NOX1/ROS/NF-κB pathway in diabetic nephropathy
SO JOURNAL OF PHARMACY AND PHARMACOLOGY
LA English
DT Article
DE caspase-1 inhibitor; VX-765; NOX1; diabetic nephropathy; inflammation
ID NADPH OXIDASE; KIDNEY; SUPEROXIDE; APOPTOSIS; INJURY; RATS
AB Objective This study explores the potential role of a highly selective caspase-1 inhibitor, VX-765, on extracellular matrix (ECM) accumulation and inflammation in diabetic nephropathy (DN) and the underlying mechanisms. Methods DN rats, induced via high-fat diet/streptozotocin, were used to assess the effects of VX-765. Parallel experiments were carried out on rat mesangial cell line HBZY-1 exposed to high glucose (HG) to reveal the molecular mechanism of VX-765 in preventing DN. Survival analysis, biochemical parameters and renal oxidative stress of rats were observed, and Western blotting and immunofluorescence were evaluated. In vitro, Nicotinamide adenine dinucleotide phosphate (NADPH) oxidases (NOX)1 silencing by RNA interference and quantitative real-time PCR (qPCR) assays were conducted in HBZY-1 cells exposed to HG levels. Key findings In vivo, VX-765 significantly reduced the increase in urine albumin excretion and ECM accumulation. The phosphorylation of nuclear factor kappa-B (NF-kappa B) and the expression of pro-inflammatory cytokines IL-1 beta, IL-6 and tumor necrosis factor (TNF)-alpha were significantly down-regulated. Furthermore, the generation of reactive oxygen species (ROS), phosphorylation of NF-kappa B and the expression of the NOX1 gene or protein were significantly decreased in HBZY-1 with VX-765 (5 mu M) treatment in vitro. Conclusions Our results demonstrated that VX-765 exerts favourable effects on DN via the simultaneous alleviation of systemic metabolic syndrome and down-regulating the renal NOX1/ROS/NF-kappa B pathway, suggesting that it has therapeutic potential for DN.
C1 [Wang, Xiaokang; Wu, Tiesong; Ma, Hongyan; Huang, Xiaoling; Huang, Kaiyuan] Guangdong Med Univ, Shenzhen Longhua Dist Cent Hosp, Affiliated Cent Hosp Shenzhen Longhua Dist, Dept Pharm, 187 Western Guanlan Ave, Shenzhen 518110, Peoples R China.
   [Ye, Chunxiao] Southern Med Univ, Dept Pharm, Shenzhen Hosp, Shenzhen, Peoples R China.
   [Zhu, Shiping] Jinan Univ, Dept Tradit Chinese Med, Affiliated Hosp 1, Guangzhou, Peoples R China.
C3 Guangdong Medical University; Shenzhen Longhua District Central
   Hospital; Southern Medical University - China; Jinan University
RP Wang, XK (corresponding author), Guangdong Med Univ, Shenzhen Longhua Dist Cent Hosp, Affiliated Cent Hosp Shenzhen Longhua Dist, Dept Pharm, 187 Western Guanlan Ave, Shenzhen 518110, Peoples R China.
EM kangtae.wang@yahoo.com
RI Zhu, Shiping/C-3754-2012; Huang, Kaiyuan/KJM-6330-2024; Wang,
   Xiaokang/GSD-7988-2022
FU Technology Project of Guangdong Province [2015B020211006]; Shenzhen
   Longhua District Science and Technology Innovation Fund Projects
   [2021105, 2020036, 2017032];  [201604020137]
FX Thiswork wassupported by the Technology Project of Guangdong Province
   [grant number 2015B020211006], Guangzhou City [grant number
   201604020137] in China and Shenzhen Longhua District Science and
   Technology Innovation Fund Projects [grant numbers 2021105, 2020036 and
   2017032].
CR Abouzed TK, 2020, J PHARM PHARMACOL, V72, P1615, DOI 10.1111/jphp.13338
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NR 32
TC 13
Z9 13
U1 1
U2 19
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0022-3573
EI 2042-7158
J9 J PHARM PHARMACOL
JI J. Pharm. Pharmacol.
PD MAR 3
PY 2022
VL 74
IS 3
BP 377
EP 386
DI 10.1093/jpp/rgab112
EA AUG 2021
PG 10
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA ZM3LT
UT WOS:000764264100008
PM 34383065
DA 2025-06-11
ER

PT J
AU Ahn, SH
   Lee, JH
   Lee, JW
AF Ahn, Sung-Ho
   Lee, Jun-Hyuk
   Lee, Ji-Won
TI Inverse association between triglyceride glucose index and muscle mass
   in Korean adults: 2008-2011 KNHANES
SO LIPIDS IN HEALTH AND DISEASE
LA English
DT Article
DE Triglyceride and glucose index; Sarcopenia; Low skeletal muscle index;
   Public health; Insulin resistance; Chronic inflammation; Inflammatory
   cytokines; Metabolic syndrome
ID INDUCED INSULIN-RESISTANCE; OXIDATIVE STRESS; FASTING GLUCOSE;
   SKELETAL-MUSCLE; WORKING GROUP; OLDER-ADULTS; TYG INDEX; SARCOPENIA;
   INFLAMMATION; PRODUCT
AB Background Since sarcopenia is an important risk factor for falls or cardiovascular disease, early detection and prevention of sarcopenia are being increasingly emphasized. Emerging evidence has indicated relationships between sarcopenia, insulin resistance, and inflammation. The triglyceride glucose (TyG) index, a novel surrogate marker of insulin resistance and systemic inflammation, has not yet been shown to be associated with sarcopenia. This study aimed to examine the relationship between the TyG index and muscle mass in Korean adults. Methods This study included 15,741 non-diabetic adults over 19 years old using data from the 2008-2011 Korea National Health and Nutrition Examination Survey. Participants were divided into three groups according to tertiles of the TyG index. A low skeletal muscle mass index (LSMI) was defined by the Foundation for the National Institutes of Health Sarcopenia Project criteria. A weighted multivariate logistic regression model was used to analyze relationships between TyG index tertiles and LSMI. Results The ORs (95% CIs) for LSMI in the second and third TyG tertiles, compared to the first tertile, were 1.463 (1.131-1.892) and 1.816 (1.394-2.366), respectively, after adjusting for confounding factors. Higher TyG index values were also associated with increased odds of LSMI in adults under 65 years who did not exercise regularly, who consumed less than 30 g of alcohol per day, who did not currently smoke, and who ate less than 1.5 g of protein/kg/day. Conclusion The TyG index was significantly and positively associated with LSMI in Korean adults.
C1 [Ahn, Sung-Ho; Lee, Jun-Hyuk; Lee, Ji-Won] Yonsei Univ, Dept Family Med, Coll Med, Seoul, South Korea.
   [Ahn, Sung-Ho; Lee, Ji-Won] Yonsei Univ, Coll Med, Gangnam Severance Hosp, Dept Family Med, 211 Eonju Ro, Seoul 06273, South Korea.
   [Lee, Jun-Hyuk] Yonsei Univ, Coll Med, Yongin Severance Hosp, Dept Family Med, 363 Dongbaekjukjeon Daero, Yongin 16995, Gyeonggi Do, South Korea.
C3 Yonsei University; Yonsei University Health System; Yonsei University;
   Yonsei University Health System; Yonsei University; Yonsei University
   Health System
RP Lee, JH; Lee, JW (corresponding author), Yonsei Univ, Dept Family Med, Coll Med, Seoul, South Korea.
EM muzzyljh@yuhs.ac; indi5645@yuhs.ac
RI LEE, Ji/C-2295-2009; Lee, Jun-Hyuk/KOC-2534-2024
OI Ahn, Sung-Ho/0000-0002-8477-1026; LEE, JI WON/0000-0002-2666-4249; Lee,
   Jun-Hyuk/0000-0002-1007-1633
FU Yonsei University College of Medicine [6-2020-0143]; Technology
   Innovation Program - Ministry of Trade, Industry & Energy (MOTIE, Korea)
   [20002781]
FX This work was supported by the 2020 faculty research grant from Yonsei
   University College of Medicine (6-2020-0143) and the Technology
   Innovation Program (20002781, A Platform for Prediction and Management
   of Health Risk Based on Personal Big Data and Lifelogging) funded by the
   Ministry of Trade, Industry & Energy (MOTIE, Korea).
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NR 61
TC 24
Z9 26
U1 0
U2 4
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1476-511X
J9 LIPIDS HEALTH DIS
JI Lipids Health Dis.
PD DEC 22
PY 2020
VL 19
IS 1
AR 243
DI 10.1186/s12944-020-01414-4
PG 9
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA PA4NM
UT WOS:000595614600002
PM 33222694
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Hanthazi, A
   Jespers, P
   Vegh, G
   Degroot, GN
   Springael, JY
   Lybaert, P
   Dewachter, L
   Mc Entee, K
AF Hanthazi, Alienor
   Jespers, Pascale
   Vegh, Gregory
   Degroot, Gaetan-Nagim
   Springael, Jean-Yves
   Lybaert, Pascale
   Dewachter, Laurence
   Mc Entee, Kathleen
TI Chemerin influences endothelin- and serotonin-induced pulmonary artery
   vasoconstriction in rats
SO LIFE SCIENCES
LA English
DT Article
DE Chemerin; Nitric oxide; Pulmonary artery; Thoracic aorta; Vascular
   reactivity
ID METABOLIC SYNDROME; SMOOTH-MUSCLE; CELLS; HYPERTENSION; INFLAMMATION;
   OBESITY; ADIPOKINE; DYSFUNCTION; DEFICIENCY; EXPRESSION
AB Aims: Chemerin has been recently identified as a vasoactive adipokine implicated in blood pressure regulation. In this context, we evaluated whether chemerin could influence pulmonary vasoreactive response.
   Materials and methods: Vascular reactivity to chemerin and to phenylephrine, serotonin and endothelin-1 after chemerin pretreatment was evaluated in rat isolated pulmonary artery versus thoracic aorta with and without endothelium. Vasoreactivity to acetylcholine in presence of nitric oxide (NO)-synthase inhibitor (L-NAME) and to NO donor sodium nitroprusside (SNP) was evaluated in chemerin-pretreated pulmonary artery versus thoracic aorta with endothelium. Pretreatment with ODQ, a soluble guanylate cyclase inhibitor and apocynin, a ROS production inhibitor, were also tested. Arteries and lung tissue were harvested for pathobiological evaluation.
   Key findings: Chemerin contracted endothelium-denuded pulmonary artery, while no response was observed in arteries with endothelium. Chemerin potentiated phenylephrine-, endothelin-1- and serotonin-induced vasoconstriction, which was further enhanced by endothelium removal. Chemerin decreased acetylcholine-induced vasorelaxation in arteries with endothelium, while it did not affect SNP-induced relaxation. In presence of L-NAME, there remained a vasorelaxation in chemerin-pretreated arteries. Chemerin or ODQ alone partly decreased acetylcholine-induced vasorelaxation in pulmonary artery and thoracic aorta, while combined chemerin and ODQ incubation abolished it. Treatment with apocynin partly or totally reversed chemerin effects. In both types of arteries, chemerin reduced acetylcholine-induced NO production, as well as endothelial and inducible NO-synthase expression.
   Significance: Chemerin potentiates vascular responses to vasoconstrictors in pulmonary artery and thoracic aorta and, impairs acetylcholine-induced pulmonary artery vasodilatation, by mechanisms involving at least partly NO signaling and oxidative stress.
C1 [Hanthazi, Alienor; Jespers, Pascale; Vegh, Gregory; Lybaert, Pascale; Dewachter, Laurence; Mc Entee, Kathleen] Univ Libre Bruxelles, Fac Med, Lab Physiol & Pharmacol, CP604 808,Lennik Rd, B-1070 Brussels, Belgium.
   [Degroot, Gaetan-Nagim; Springael, Jean-Yves] Univ Libre Bruxelles, Fac Med, Inst Interdisciplinary Res IRIBHM, Brussels, Belgium.
C3 Universite Libre de Bruxelles; Universite Libre de Bruxelles
RP Hanthazi, A (corresponding author), Univ Libre Bruxelles, Fac Med, Lab Physiol & Pharmacol, CP604 808,Lennik Rd, B-1070 Brussels, Belgium.
EM Alienor.Hanthazi@ulb.ac.be
OI Degroot, Gaetan-Nagim/0009-0005-5270-1161; Hanthazi,
   Alienor/0000-0001-6360-3317
FU "Fonds pour la Chirurgie Cardiaque" (Brussels, Belgium); "Fondation
   BEKALES" (Brussels, Belgium)
FX This work was supported by funds from the "Fonds pour la Chirurgie
   Cardiaque" (Brussels, Belgium) and from the "Fondation BEKALES"
   (Brussels, Belgium).
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NR 52
TC 16
Z9 16
U1 0
U2 6
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0024-3205
EI 1879-0631
J9 LIFE SCI
JI Life Sci.
PD AUG 15
PY 2019
VL 231
AR 116580
DI 10.1016/j.lfs.2019.116580
PG 10
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA IR7KU
UT WOS:000481620400059
PM 31216440
OA Green Published
DA 2025-06-11
ER

PT J
AU Namazi, N
   Larijani, B
   Azadbakht, L
AF Namazi, Nazli
   Larijani, Bagher
   Azadbakht, Leila
TI Alpha-lipoic acid supplement in obesity treatment: A systematic review
   and meta-analysis of clinical trials
SO CLINICAL NUTRITION
LA English
DT Review
DE Alpha-lipoic acid; Obesity; Overweight; Weight-loss
ID OXIDATIVE STRESS; ENDOTHELIAL DYSFUNCTION; INSULIN-RESISTANCE; METABOLIC
   SYNDROME; WEIGHT; ANTIOXIDANT; OVERWEIGHT; GLUCOSE; WOMEN; MAINTENANCE
AB Background & aims: Previous studies have supported positive roles of antioxidant supplements on weight-loss. One antioxidant supplement is Alpha-lipoic acid. However, recommending ALA as an anti-obesity supplement remains controversial. Accordingly, the purpose of the present study was to perform a meta-analysis on the effects of ALA supplement on anthropometric indices among adult subjects.
   Methods: We searched five electronic databases till September 2016. Placebo-controlled clinical trials were included. Weighted Mean Difference (WMD) was pooled using a random-effects model.
   Results: Findings of 12 included trials indicated that ALA supplement reduced body weight (WMD: -0.69 kg; 95% CI: -1.27, -0.10; I-2 = 0%) and BMI (WMD: -0.38 kg/m(2); 95% CI: -0.53, -0.24; I-2 = 0%) significantly compared to the placebo group. However, its effects on Waist Circumference (WC) was not significant (WMD: -0.30 cm; 95% CI: -1.18, -0.58; I-2 = 17.8%). Stratification by health status indicated that ALA decreased WC in unhealthy subjects (WMD: -2.00 cm; 95% CI: -4.19, 0.19; I-2 = 1.3%) more than healthy individuals (0.03 cm; 95% CI: -0.69, 0.75; I-2 = 0%).
   Conclusions: The present study revealed that supplementation with ALA slightly but significantly decreased body weight and BMI. Safe dosage for ALA is up to 1200 mg/day. However, it seems that ALA cannot be cost-effective. Further studies are needed to clarify the effects of ALA on metabolic parameter in unhealthy obese individuals. (C) 2017 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.
C1 [Namazi, Nazli] Univ Tehran Med Sci, Obes & Eating Habits Res Ctr, Endocrinol & Metab Mol Cellular Sci Inst, Tehran, Iran.
   [Larijani, Bagher] Univ Tehran Med Sci, Endocrinol & Metab Clin Sci Inst, Endocrinol & Metab Res Ctr, POB 1411413137, Tehran, Iran.
   [Azadbakht, Leila] Univ Tehran Med Sci, Endocrinol & Metab Clin Sci Inst, Diabet Res Ctr, Tehran, Iran.
   [Azadbakht, Leila] Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Community Nutr, POB 1416643931, Tehran, Iran.
   [Azadbakht, Leila] Isfahan Univ Med Sci, Food Secur Res Ctr, Sch Nutr & Food Sci, Dept Community Nutr, Esfahan, Iran.
C3 Tehran University of Medical Sciences; Tehran University of Medical
   Sciences; Tehran University of Medical Sciences; Tehran University of
   Medical Sciences; Isfahan University of Medical Sciences
RP Larijani, B (corresponding author), Univ Tehran Med Sci, Endocrinol & Metab Clin Sci Inst, Endocrinol & Metab Res Ctr, POB 1411413137, Tehran, Iran.; Azadbakht, L (corresponding author), Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Community Nutr, POB 1416643931, Tehran, Iran.
EM larijanib@tums.ac.ir; azadbakhtleila@gmail.com
RI larijani, Bagher/ABE-3315-2020; Azadbakht, Leila/N-2801-2018
OI Azadbakht, Leila/0000-0002-5955-6818
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NR 54
TC 85
Z9 88
U1 0
U2 16
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0261-5614
EI 1532-1983
J9 CLIN NUTR
JI Clin. Nutr.
PD APR
PY 2018
VL 37
IS 2
BP 419
EP 428
DI 10.1016/j.clnu.2017.06.002
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA GA6ZG
UT WOS:000428483200002
PM 28629898
DA 2025-06-11
ER

PT J
AU Sun, F
   Xiong, SQ
   Zhu, ZM
AF Sun, Fang
   Xiong, Shiqiang
   Zhu, Zhiming
TI Dietary Capsaicin Protects Cardiometabolic Organs from Dysfunction
SO NUTRIENTS
LA English
DT Review
DE chili pepper; capsaicin; TRPV1; metabolic syndrome; obesity;
   hypertension; diabetes
ID HIGH-FAT DIET; POTENTIAL VANILLOID TYPE-1; HEALTHY-HUMAN SUBJECTS;
   INSULIN-SECRETION; SUBSTRATE UTILIZATION; ANALOGS CAPSINOIDS; PROTEOMIC
   ANALYSIS; HYPERTENSIVE-RATS; INDUCED OBESITY; RECEPTOR TRPV1
AB Chili peppers have a long history of use for flavoring, coloring, and preserving food, as well as for medical purposes. The increased use of chili peppers in food is very popular worldwide. Capsaicin is the major pungent bioactivator in chili peppers. The beneficial effects of capsaicin on cardiovascular function and metabolic regulation have been validated in experimental and population studies. The receptor for capsaicin is called the transient receptor potential vanilloid subtype 1 (TRPV1). TRPV1 is ubiquitously distributed in the brain, sensory nerves, dorsal root ganglia, bladder, gut, and blood vessels. Activation of TRPV1 leads to increased intracellular calcium signaling and, subsequently, various physiological effects. TRPV1 is well known for its prominent roles in inflammation, oxidation stress, and pain sensation. Recently, TRPV1 was found to play critical roles in cardiovascular function and metabolic homeostasis. Experimental studies demonstrated that activation of TRPV1 by capsaicin could ameliorate obesity, diabetes, and hypertension. Additionally, TRPV1 activation preserved the function of cardiometabolic organs. Furthermore, population studies also confirmed the beneficial effects of capsaicin on human health. The habitual consumption of spicy foods was inversely associated with both total and certain causes of specific mortality after adjustment for other known or potential risk factors. The enjoyment of spicy flavors in food was associated with a lower prevalence of obesity, type 2 diabetes, and cardiovascular diseases. These results suggest that capsaicin and TRPV1 may be potential targets for the management of cardiometabolic vascular diseases and their related target organs dysfunction.
C1 [Sun, Fang; Xiong, Shiqiang; Zhu, Zhiming] Third Mil Med Univ, Chongqing Inst Hypertens, Daping Hosp, Ctr Hypertens & Metab Dis,Dept Hypertens & Endocr, Chongqing 400042, Peoples R China.
C3 Army Medical University
RP Zhu, ZM (corresponding author), Third Mil Med Univ, Chongqing Inst Hypertens, Daping Hosp, Ctr Hypertens & Metab Dis,Dept Hypertens & Endocr, Chongqing 400042, Peoples R China.
EM sun_fang2007@163.com; xionglliu@163.com; zhuzm@yahoo.com
RI Zhu, Zhiming/AAH-6111-2021; Xiong, Shiqiang/HCH-4644-2022
OI Xiong, Shiqiang/0000-0002-9936-5143
FU National Basic Research Program of China [2012CB517805, 2013CB531205];
   National Natural Science Foundation of China [91339112, 31430042,
   91339000]; PCSIRT
FX This review was supported by the National Basic Research Program of
   China (2012CB517805, and 2013CB531205), The National Natural Science
   Foundation of China (91339112, 31430042, and 91339000), and supported by
   PCSIRT.
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NR 89
TC 81
Z9 90
U1 2
U2 52
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 2072-6643
J9 NUTRIENTS
JI Nutrients
PD MAY
PY 2016
VL 8
IS 5
AR 174
DI 10.3390/nu8050174
PG 13
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA DP8XI
UT WOS:000378780900004
PM 27120617
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Bundalo, MM
   Zivkovic, MD
   Romic, SD
   Tepavcevic, SN
   Koricanac, GB
   Djuric, TM
   Stankovic, AD
AF Bundalo, Maja M.
   Zivkovic, Maja D.
   Romic, Snjezana Dj
   Tepavcevic, Snezana N.
   Koricanac, Goran B.
   Djuric, Tamara M.
   Stankovic, Aleksandra D.
TI Fructose-rich diet induces gender-specific changes in expression of the
   renin-angiotensin system in rat heart and upregulates the ACE/AT1R axis
   in the male rat aorta
SO JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM
LA English
DT Article
DE Angiotensin-converting enzyme; angiotensin receptor; aorta; diet;
   fructose; gender differences; heart; protein expression; rat;
   renin-angiotensin system
ID INSULIN-RESISTANCE; VASCULAR DYSFUNCTION; METABOLIC SYNDROME; GLOMERULAR
   HYPERTENSION; OXIDATIVE STRESS; BLOOD-PRESSURE; FEMALE RATS; RECEPTOR;
   DECREASES; MODEL
AB Introduction: The cardiovascular renin-angiotensin system (RAS) could be affected by gender and dietary regime. We hypothesized that male rats will be more susceptible to activation of RAS in the heart and aorta, as a response to a fructose-rich diet (FRD).
   Materials and methods: Both male and female Wistar rats were given a 10% (w/v) fructose solution for 9 weeks. We measured the biochemical parameters, blood pressure (BP) and heart rate. We used Western blot and real-time polymerase chain reaction (PCR) to quantify protein and gene expression.
   Results: In the male rats, the FRD elevated BP and expression of cardiac angiotensin-converting enzyme (ACE), while the expression of angiotensin-converting enzyme 2 (ACE2) and angiotensin II Type 2 receptor (AT(2)R) were significantly decreased. In female rats, there were no changes in cardiac RAS expression due to FRD. Furthermore, the ACE/AT(1)R axis was overexpressed in the FRD male rats' aortae, while only AT(1)R was upregulated in the FRD female rats' aortae. ACE2 expression remained unchanged in the aortae of both genders receiving the FRD.
   Conclusions: The FRD induced gender-specific changes in the expression of the RAS in the heart and aortae of male rats. Further investigations are required in order to get a comprehensive understanding of the underlying mechanisms of gender-specific fructose-induced cardiovascular pathologies.
C1 [Bundalo, Maja M.; Zivkovic, Maja D.; Djuric, Tamara M.; Stankovic, Aleksandra D.] Univ Belgrade, Vinca Inst Nucl Sci, Lab Radiobiol & Mol Genet, POB 522, Belgrade 11000, Serbia.
   [Romic, Snjezana Dj; Tepavcevic, Snezana N.; Koricanac, Goran B.] Univ Belgrade, Vinca Inst Nucl Sci, Lab Mol Biol & Endocrinol, POB 522, Belgrade 11000, Serbia.
C3 University of Belgrade; University of Belgrade
RP Stankovic, AD (corresponding author), Univ Belgrade, Vinca Inst Nucl Sci, Lab Radiobiol & Mol Genet, POB 522, Belgrade 11000, Serbia.
EM alexas@vinca.rs
RI Korićanac, Goran/ABF-6544-2021; Zivkovic, Maja/T-1038-2018; Stankovic,
   Aleksandra/T-1064-2018
OI Djuric, Tamara/0000-0002-9857-9828; Tepavcevic,
   Snezana/0000-0002-5758-070X; Zivkovic, Maja/0000-0002-0447-6626;
   Koricanac, Goran/0000-0002-9852-3330; Stankovic,
   Aleksandra/0000-0002-1050-5913; Bundalo, Maja/0000-0002-0589-2672;
   Romic, Snjezana/0000-0002-3346-7438
FU Ministry of Education, Science and Technological Development of the
   Republic of Serbia [ON175085, III 41009]
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: This work
   was supported by the Ministry of Education, Science and Technological
   Development of the Republic of Serbia (grant numbers ON175085 and III
   41009).
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NR 44
TC 22
Z9 23
U1 0
U2 1
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1470-3203
EI 1752-8976
J9 J RENIN-ANGIO-ALDO S
JI J. Renin-Angiotensin-Aldosterone Syst.
PD APR-JUN
PY 2016
VL 17
IS 2
AR 1470320316642915
DI 10.1177/1470320316642915
PG 10
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA DP1UB
UT WOS:000378273800003
PM 27121972
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Rodriguez-Ramiro, I
   Vauzour, D
   Minihane, AM
AF Rodriguez-Ramiro, I.
   Vauzour, D.
   Minihane, A. M.
TI Polyphenols and non-alcoholic fatty liver disease: impact and mechanisms
SO PROCEEDINGS OF THE NUTRITION SOCIETY
LA English
DT Article; Proceedings Paper
CT Meeting of the Scottish-Section of the Nutrition-Society / Conference on
   Diet, Gene Regulation and Metabolic Disease / Symposium 2 on
   Micronutrients, Phytochemicals, Gene Expression and Metabolic Disease
CY MAR 25-26, 2015
CL Robert Gordon Univ, Aberdeen, SCOTLAND
SP Nutr Soc, Scottish Sect
HO Robert Gordon Univ
DE Flavonoids; Steatosis; Sterol regulatory element; binding protein 1c;
   PPAR alpha; Insulin resistance; Obesity
ID ACTIVATED PROTEIN-KINASE; INDUCED HEPATIC STEATOSIS; INSULIN-RESISTANCE;
   OXIDATIVE STRESS; HEPG2 CELLS; IN-VITRO; DISEASE/NONALCOHOLIC
   STEATOHEPATITIS; MITOCHONDRIAL DYSFUNCTION; LIPID-ACCUMULATION;
   ADIPOSE-TISSUE
AB Proceedings of the Nutrition Society Non-alcoholic fatty liver disease (NAFLD) is considered to be the hepatic component of the metabolic syndrome and its prevalence is rapidly increasing due to its strong association with insulin resistance and obesity. At present, given that NAFLD is highly prevalent and therapies are limited, much attention is focused on identifying effective dietary strategies for the prevention and treatment of the disease. Polyphenols are a group of plant bioactive compounds whose regular consumption have been associated with a reduction in the risk of a number of metabolic disorders associated with NAFLD. Here we review the emerging and relatively consistent evidence from cell culture and rodent studies showing that select polyphenols positively modulate a variety of contributors to the NAFLD phenotype, through diverse and complementary mechanisms of action. In particular, the reduction of de novo lipogenesis (via sterol regulatory element-binding protein 1c) and increased fatty acid beta-oxidation, presumably involving AMP-activated protein kinase activation, will be discussed. The indirect antioxidant and anti-inflammatory properties of polyphenols which have been reported to contribute to the amelioration of NAFLD will also be addressed. In addition to a direct study of the liver, rodent studies have provided insight into the impact of polyphenols on adipose tissue function and whole body insulin sensitivity, which are likely to in part modulate their impact on NAFLD development. Finally an overview of the limited data from clinical trials will be given along with a discussion of the dose extrapolation from animal studies to human subjects.
C1 [Rodriguez-Ramiro, I.] Univ E Anglia, Norwich Med Sch, Dept Med, Norwich NR4 7TJ, Norfolk, England.
   [Vauzour, D.; Minihane, A. M.] Univ E Anglia, Norwich Med Sch, Dept Nutr, Norwich NR4 7TJ, Norfolk, England.
C3 University of East Anglia; University of East Anglia
RP Rodriguez-Ramiro, I (corresponding author), Univ E Anglia, Norwich Med Sch, Dept Med, Norwich NR4 7TJ, Norfolk, England.
EM i.rodriguez-ramiro@uea.ac.uk
RI Rodriguez-Ramiro, Ildefonso/AHE-4989-2022; VAUZOUR, David/C-2245-2008
OI Rodriguez-Ramiro, Ildefonso/0000-0002-7845-3734; VAUZOUR,
   David/0000-0001-5952-8756
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NR 76
TC 138
Z9 145
U1 7
U2 58
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0029-6651
EI 1475-2719
J9 P NUTR SOC
JI Proc. Nutr. Soc.
PD FEB
PY 2016
VL 75
IS 1
BP 47
EP 60
DI 10.1017/S0029665115004218
PG 14
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Nutrition & Dietetics
GA DC7RU
UT WOS:000369418800006
PM 26592314
OA Bronze, Green Accepted
DA 2025-06-11
ER

PT J
AU Schneider, H
   Schubert, KM
   Blodow, S
   Kreutz, CP
   Erdogmus, S
   Wiedenmann, M
   Qiu, JH
   Fey, T
   Ruth, P
   Lubomirov, LT
   Pfitzer, G
   Schnitzler, MMY
   Hardie, DG
   Gudermann, T
   Pohl, U
AF Schneider, Holger
   Schubert, Kai Michael
   Blodow, Stephanie
   Kreutz, Claus-Peter
   Erdogmus, Serap
   Wiedenmann, Margarethe
   Qiu, Jiehua
   Fey, Theres
   Ruth, Peter
   Lubomirov, Lubomir T.
   Pfitzer, Gabriele
   Mederos y Schnitzler, Michael
   Hardie, D. Grahame
   Gudermann, Thomas
   Pohl, Ulrich
TI AMPK Dilates Resistance Arteries via Activation of SERCA and
   BKCa Channels in Smooth Muscle
SO HYPERTENSION
LA English
DT Article
DE muscle; smooth; vascular; phospholamban; vasodilation
ID ENDOPLASMIC-RETICULUM STRESS; LOWERS BLOOD-PRESSURE; WHOLE-BODY LEVELS;
   PROTEIN-KINASE; ENDOTHELIAL-CELLS; SARCOPLASMIC-RETICULUM;
   HYPERTENSIVE-RATS; CA2+ SENSITIVITY; IN-VIVO; MICE
AB The protective effects of 5-AMP-activated protein kinase (AMPK) on the metabolic syndrome may include direct effects on resistance artery vasomotor function. However, the precise actions of AMPK on microvessels and their potential interaction are largely unknown. Thus, we set to determine the effects of AMPK activation on vascular smooth muscle tone and the underlying mechanisms. Resistance arteries isolated from hamster and mouse exhibited a pronounced endothelium-independent dilation on direct pharmacological AMPK activation by 2 structurally unrelated compounds (PT1 and A769662). The dilation was associated with a decrease of intracellular-free calcium [Ca2+](i) in vascular smooth muscle cell. AMPK stimulation induced activation of BKCa channels as assessed by patch clamp studies in freshly isolated hamster vascular smooth muscle cell and confirmed by direct proof of membrane hyperpolarization in intact arteries. The BKCa channel blocker iberiotoxin abolished the hyperpolarization but only partially reduced the dilation and did not affect the decrease of [Ca2+](i). By contrast, the sarcoplasmic/endoplasmic Ca2+-ATPase (SERCA) inhibitor thapsigargin largely reduced these effects, whereas combined inhibition of SERCA and BKCa channels virtually abolished them. AMPK stimulation significantly increased the phosphorylation of the SERCA modulator phospholamban at the regulatory T17 site. Stimulation of smooth muscle AMPK represents a new, potent vasodilator mechanism in resistance vessels. AMPK directly relaxes vascular smooth muscle cell by a decrease of [Ca2+](i). This is achieved by calcium sequestration via SERCA activation, as well as activation of BKCa channels. There is in part a mutual compensation of both calcium-lowering mechanisms. However, SERCA activation which involves an AMPK-dependent phosphorylation of phospholamban is the predominant mechanism in resistance vessels.
C1 [Schneider, Holger; Schubert, Kai Michael; Blodow, Stephanie; Kreutz, Claus-Peter; Wiedenmann, Margarethe; Qiu, Jiehua; Fey, Theres; Pohl, Ulrich] Univ Munich, Walter Brendel Ctr Expt Med, Munich, Germany.
   [Schneider, Holger; Schubert, Kai Michael; Blodow, Stephanie; Kreutz, Claus-Peter; Wiedenmann, Margarethe; Qiu, Jiehua; Fey, Theres; Pohl, Ulrich] Univ Munich, Biomed Ctr, Munich, Germany.
   [Erdogmus, Serap; Mederos y Schnitzler, Michael; Gudermann, Thomas] Univ Munich, Walther Straub Inst, Pharmacol, Munich, Germany.
   [Schneider, Holger; Schubert, Kai Michael; Blodow, Stephanie; Pohl, Ulrich] Munich Cluster Syst Neurol SyNergy, Munich, Germany.
   [Schneider, Holger; Schubert, Kai Michael; Blodow, Stephanie; Fey, Theres; Mederos y Schnitzler, Michael; Gudermann, Thomas; Pohl, Ulrich] Partner Site Munich Heart Alliance, DZHK German Ctr Cardiovasc Res, Munich, Germany.
   [Hardie, D. Grahame] Univ Dundee, Div Cell Signalling & Immunol, Dundee DD1 4HN, Scotland.
   [Lubomirov, Lubomir T.; Pfitzer, Gabriele] Univ Cologne, Inst Vegetat Physiol, D-50931 Cologne, Germany.
   [Ruth, Peter] Univ Tubingen, Dept Pharm, Pharmacol Toxicol & Clin Pharm, Tubingen, Germany.
C3 University of Munich; University of Munich; University of Munich;
   University of Munich; Munich Heart Alliance; German Centre for
   Cardiovascular Research; University of Dundee; University of Cologne;
   Eberhard Karls University of Tubingen
RP Pohl, U (corresponding author), Walter Brendel Ctr, Marchioninistr 27, D-81377 Munich, Germany.
EM upohl@lmu.de
RI Hardie, David/Z-1979-2019; Lubomirov, Lubomir/GRE-9266-2022
OI Fey, Theres/0000-0002-9947-3275; Schneider, Holger/0000-0003-1556-0951
FU Munich Cluster for Systems Neurology (SyNergy), Munich, Germany;
   EXGENESIS EU [5272]
FX This work was financed through grants from the Munich Cluster for
   Systems Neurology (SyNergy), Munich, Germany, and, in the beginning, the
   EXGENESIS EU project # 5272 (FP6 LIFESCIHEALTH).
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NR 42
TC 58
Z9 63
U1 0
U2 11
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0194-911X
EI 1524-4563
J9 HYPERTENSION
JI Hypertension
PD JUL
PY 2015
VL 66
IS 1
BP 108
EP 116
DI 10.1161/HYPERTENSIONAHA.115.05514
PG 9
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA CL6MD
UT WOS:000357080300018
PM 26034200
DA 2025-06-11
ER

PT J
AU Dellamea, BS
   Leitao, CB
   Friedman, R
   Canani, LH
AF Dellamea, Bruno Schmidt
   Leitao, Cristiane Bauermann
   Friedman, Rogerio
   Canani, Luis Henrique
TI Nitric oxide system and diabetic nephropathy
SO DIABETOLOGY & METABOLIC SYNDROME
LA English
DT Review
DE Diabetes; Diabetic nephropathy; Polymorphism; eNOS; NOS-3; G894T; 4b/a;
   T786C
ID SYNTHASE GENE POLYMORPHISMS; GLU298ASP POLYMORPHISM; INTRON-4
   POLYMORPHISM; METABOLIC SYNDROME; OXIDATIVE STRESS; ENDOTHELIAL
   FUNCTION; RENAL-DISEASE; RISK-FACTORS; ASSOCIATION; PROGRESSION
AB About 30% of patients with type 2 diabetes mellitus develop clinically overt nephropathy. Hyperglycemia is necessary, but not sufficient, to cause the renal damage that leads to kidney failure. Diabetic nephropathy (DN) is a multifactorial disorder that results from interaction between environmental and genetic factors. In the present article we will review the role of the nitric oxide synthase (NOS) in the pathogenesis of DN.
   Nitric oxide (NO) is a short-lived gaseous lipophilic molecule produced in almost all tissues, and it has three distinct genes that encode three NOS isoforms: neuronal (nNOS), inducible (iNOS) and endothelial (eNOS).
   The correct function of the endothelium depends on NO, participating in hemostasis control, vascular tone regulation, proliferation of vascular smooth muscle cells and blood pressure homeostasis, among other features. In the kidney, NO plays many different roles, including control of renal and glomerular hemodynamics. The net effect of NO in the kidney is to promote natriuresis and diuresis, along with renal adaptation to dietary salt intake.
   The eNOS gene has been considered a potential candidate gene for DN susceptibility. Three polymorphisms have been extensively researched: G894T missense mutation (rs1799983), a 27-bp repeat in intron 4, and the T786C single nucleotide polymorphism (SNP) in the promoter (rs2070744). However, the potential link between eNOS gene variants and the induction and progression of DN yielded contradictory results in the literature.
   In conclusion, NOS seems to be involve in the development and progression of DN. Despite the discrepant results of many studies, the eNOS gene is also a good candidate gene for DN.
C1 [Dellamea, Bruno Schmidt; Leitao, Cristiane Bauermann; Friedman, Rogerio; Canani, Luis Henrique] Univ Fed Rio Grande do Sul, Porto Alegre, RS, Brazil.
   [Leitao, Cristiane Bauermann; Friedman, Rogerio; Canani, Luis Henrique] Hosp Clin Porto Alegre, Div Endocrine, Porto Alegre, RS, Brazil.
C3 Universidade Federal do Rio Grande do Sul; Hospital de Clinicas de Porto
   Alegre
RP Dellamea, BS (corresponding author), Univ Fed Rio Grande do Sul, Porto Alegre, RS, Brazil.
EM brunodellamea@gmail.com
RI Leitao, Cristiane/H-4022-2017; Canani, Luis/G-9686-2012; Friedman,
   Rogerio/H-9718-2012
OI Leitao, Cristiane/0000-0002-2106-309X; Friedman,
   Rogerio/0000-0003-2802-4242
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NR 71
TC 88
Z9 97
U1 0
U2 23
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1758-5996
J9 DIABETOL METAB SYNDR
JI Diabetol. Metab. Syndr.
PD FEB 12
PY 2014
VL 6
AR 17
DI 10.1186/1758-5996-6-17
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA AB9HF
UT WOS:000332101400001
PM 24520999
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Sell, H
   Blüher, M
   Klöting, N
   Schlich, R
   Willems, M
   Ruppe, F
   Knoefel, WT
   Dietrich, A
   Fielding, BA
   Arner, P
   Frayn, KN
   Eckel, J
AF Sell, Henrike
   Blueher, Matthias
   Kloeting, Nora
   Schlich, Raphaela
   Willems, Miriam
   Ruppe, Florian
   Knoefel, Wolfram Trudo
   Dietrich, Arne
   Fielding, Barbara A.
   Arner, Peter
   Frayn, Keith N.
   Eckel, Juergen
TI Adipose Dipeptidyl Peptidase-4 and Obesity Correlation with insulin
   resistance and depot-specific release from adipose tissue in vivo and in
   vitro
SO DIABETES CARE
LA English
DT Article
ID GLUCOSE-TOLERANCE; METABOLISM; GENE; INFLAMMATION; SITAGLIPTIN;
   EXPRESSION; SECRETION; STRESS; DPP4; LINK
AB OBJECTIVETo study expression of the recently identified adipokine dipeptidyl peptidase-4 (DPP4) in subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) of patients with various BMIs and insulin sensitivities, as well as to assess circulating DPP4 in relation to obesity and insulin sensitivity.RESEARCH DESIGN AND METHODSDPP4 expression was measured in SAT and VAT from 196 subjects with a wide range of BMIs and insulin sensitivities. DPP4 release was measured ex vivo in paired biopsies from SAT and VAT as well as in vivo from SAT of lean and obese patients. Circulating DPP4 was measured in insulin-sensitive and insulin-resistant BMI-matched obese patients.RESULTSDPP4 expression was positively correlated with BMI in both SAT and VAT, with VAT consistently displaying higher expression than SAT. Ex vivo release of DPP4 from adipose tissue explants was higher in VAT than in SAT in both lean and obese patients, with obese patients displaying higher DPP4 release than lean controls. Net release of DPP4 from adipose tissue was also demonstrated in vivo with greater release in obese subjects than in lean subjects and in women than in men. Insulin-sensitive obese patients had significantly lower circulating DPP4 than did obesity-matched insulin-resistant patients. In this experiment, DPP4 positively correlated with the amount of VAT, adipocyte size, and adipose tissue inflammation.CONCLUSIONSDPP4, a novel adipokine, has a higher release from VAT that is particularly pronounced in obese and insulin-resistant patients. Our data suggest that DPP4 may be a marker for visceral obesity, insulin resistance, and the metabolic syndrome.
C1 [Sell, Henrike; Schlich, Raphaela; Willems, Miriam; Eckel, Juergen] German Diabet Ctr, Paul Langerhans Grp Integrat Physiol, Dusseldorf, Germany.
   [Blueher, Matthias; Kloeting, Nora] Univ Leipzig, Dept Med, D-04109 Leipzig, Germany.
   [Willems, Miriam; Ruppe, Florian; Knoefel, Wolfram Trudo] Univ Dusseldorf, Dept Gen Visceral & Pediat Surg, Dusseldorf, Germany.
   [Willems, Miriam; Ruppe, Florian; Knoefel, Wolfram Trudo] Univ Hosp Dusseldorf, Dusseldorf, Germany.
   [Dietrich, Arne] Univ Leipzig, Dept Surg, D-04109 Leipzig, Germany.
   [Fielding, Barbara A.; Frayn, Keith N.] Churchill Hosp, Oxford Ctr Diabet Endocrinol & Metab, Oxford OX3 7LJ, England.
   [Fielding, Barbara A.] Univ Surrey, Fac Hlth & Med Sci, Guildford GU2 5XH, Surrey, England.
   [Arner, Peter] Karolinska Inst, Karolinska Univ Hosp Huddinge, Dept Med, Stockholm, Sweden.
C3 Leibniz Association; Deutsches Diabetes-Zentrum (DDZ); Leipzig
   University; Heinrich Heine University Dusseldorf; Heinrich Heine
   University Dusseldorf; Heinrich Heine University Dusseldorf Hospital;
   Leipzig University; University of Oxford; University of Surrey;
   Karolinska Institutet; Karolinska University Hospital
RP Sell, H (corresponding author), German Diabet Ctr, Paul Langerhans Grp Integrat Physiol, Dusseldorf, Germany.
EM henrike.sell@ddz.uni-duesseldorf.de
OI Frayn, Keith/0000-0001-7281-1863; Sell, Henrike/0000-0001-6323-6158;
   Eckel, Juergen/0000-0003-3645-5288; Fielding,
   Barbara/0000-0001-7887-809X; Arner, Peter/0000-0002-6208-6220
FU Ministerium fur Wissenschaft und Forschung des Landes
   Nordrhein-Westfalen (Ministry of Science and Research of the State of
   NorthRhine-Westphalia); Bundesministerium fur Gesundheit (Federal
   Ministry of Health); German Research Council [SE 1922/2-1]; Commission
   of the European Communities [HEALTH-F2-2008-201100,
   LSHM-CT-2005-018734]; European Union COST Action [BM0602]; Kompetenznetz
   Adipositas (Competence Network for Obesity); Federal Ministry of
   Education and Research (German Obesity Biomaterial Bank) [FKZ 01GI1128];
   Deutsche Forschungsgemeinschaft the Clinical Research group Atherobesity
   [KFO 152, BL 833/1-1]; Swedish Research Council; EASD/Lilly; Novo
   Nordisk Foundation
FX This work was supported by the Ministerium fur Wissenschaft und
   Forschung des Landes Nordrhein-Westfalen (Ministry of Science and
   Research of the State of NorthRhine-Westphalia), the Bundesministerium
   fur Gesundheit (Federal Ministry of Health), the German Research Council
   (SE 1922/2-1), the Commission of the European Communities (Collaborative
   Project ADAPT, Contract No. HEALTH-F2-2008-201100; Integrated Project
   HEPADIP, Contract LSHM-CT-2005-018734), and European Union COST Action
   BM0602. This work was further supported by the Kompetenznetz Adipositas
   (Competence Network for Obesity) funded by the Federal Ministry of
   Education and Research (German Obesity Biomaterial Bank; FKZ 01GI1128)
   and a grant from Deutsche Forschungsgemeinschaft the Clinical Research
   group Atherobesity KFO 152 (project BL 833/1-1), both to M. B. The study
   was also supported by grants from Swedish Research Council, EASD/Lilly,
   and the Novo Nordisk Foundation (P.A.).
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NR 35
TC 177
Z9 188
U1 0
U2 13
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0149-5992
EI 1935-5548
J9 DIABETES CARE
JI Diabetes Care
PD DEC
PY 2013
VL 36
IS 12
BP 4083
EP 4090
DI 10.2337/dc13-0496
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 255AL
UT WOS:000327211500061
PM 24130353
OA Green Published, hybrid, Green Submitted
DA 2025-06-11
ER

PT J
AU Pirillo, A
   Norata, GD
   Catapano, AL
AF Pirillo, Angela
   Norata, Giuseppe Danilo
   Catapano, Alberico Luigi
TI Treating High Density Lipoprotein Cholesterol (HDL-C): Quantity Versus
   Quality
SO CURRENT PHARMACEUTICAL DESIGN
LA English
DT Article
DE High density lipoprotein (HDL); dysfunctional HDL; HDL function; HDL
   subpopulations; coronary heart disease; residual cardiovascular risk
ID CORONARY-HEART-DISEASE; APOLIPOPROTEIN-A-I; ESTER TRANSFER PROTEIN;
   EXTENDED-RELEASE NIACIN; CYTOKINE-INDUCED EXPRESSION; ELEVATED OXIDATIVE
   STRESS; ARTERIAL-WALL THICKNESS; ANTIINFLAMMATORY PROPERTIES;
   CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME
AB Low density lipoproteins (LDL) and high density lipoproteins (HDL) are independent risk factors for coronary heart disease (CHD); decreasing LDL-cholesterol (LDL-C) levels with statin therapy represents the primary goal in the management of cardiovascular disease. However, despite the efficacy of statins in reducing cardiovascular morbidity and mortality, a significant residual risk has been observed even after reaching the LDL-C target, suggesting that other risk factors beyond LDL-C should be addressed, including low levels of HDL-cholesterol (HDL-C). Several clinical trials have shown an inverse relationship between HDL-C levels and cardiovascular risk, and 1 mg/dl increment in HDL-C is associated in epidemiological studies with a 2-3% decrease in cardiovascular risk, suggesting that raising HDL-C levels might have beneficial effects to reduce cardiovascular disease.
   However, several lines of evidence indicate that the functional properties of HDL may be relevant as well. In patient with CAD and normal HDL-C levels, HDL exhibit significantly reduced protective functions, and rather appear to be pro-atherogenic; on the other hand some genetic mutations causing low levels of HDL-C are not associated with increased atherosclerosis. Furthermore, although niacin significantly increased HDL-C levels, no further clinical benefit was observed from the addition of niacin to statin therapy, suggesting that increasing HDL-C levels is not sufficient and perhaps functional properties of HDL must be considered when choosing a therapeutic strategy to reduce the residual cardiovascular risk.
C1 [Pirillo, Angela] Bassini Hosp, Ctr Study Atherosclerosis, Cinisello Balsamo, Italy.
   [Pirillo, Angela; Catapano, Alberico Luigi] IRCCS Multimed, Milan, Italy.
   [Norata, Giuseppe Danilo; Catapano, Alberico Luigi] Univ Milan, Dept Pharmacol & Biomol Sci, I-20133 Milan, Italy.
   [Norata, Giuseppe Danilo] Queens Mary Univ, Barts & London Sch Med & Dent, Ctr Diabet, Blizard Inst, London, England.
C3 IRCCS Multimedica; University of Milan; University of London; Queen Mary
   University London
RP Pirillo, A (corresponding author), Univ Milan, Dept Pharmacol Sci, Via Balzaretti 9, I-20133 Milan, Italy.
EM angela.pirillo@guest.unimi.it; alberico.catapano@unimi.it
RI Catapano, alberico/AAC-2827-2019; Pirillo, Angela/C-4228-2014
OI Pirillo, Angela/0000-0002-2948-6257; Catapano, Alberico
   Luigi/0000-0002-7593-2094; Norata, Giuseppe Danilo/0000-0002-6081-1257
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NR 212
TC 25
Z9 26
U1 0
U2 15
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1381-6128
EI 1873-4286
J9 CURR PHARM DESIGN
JI Curr. Pharm. Design
PD JUN
PY 2013
VL 19
IS 21
BP 3841
EP 3857
DI 10.2174/13816128113199990298
PG 17
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 140WM
UT WOS:000318687100009
PM 23286430
DA 2025-06-11
ER

PT J
AU Sunto, A
   Mochizuki, K
   Miyauchi, R
   Misaki, Y
   Shimada, M
   Kasezawa, N
   Tohyama, K
   Goda, T
AF Sunto, Akiko
   Mochizuki, Kazuki
   Miyauchi, Rie
   Misaki, Yasumi
   Shimada, Masaya
   Kasezawa, Nobuhiko
   Tohyama, Kazushige
   Goda, Toshinao
TI Serum γ-GTP Activity Is Closely Associated with Serum CRP Levels in
   Non-Overweight and Overweight Middle-Aged Japanese Men
SO JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY
LA English
DT Article
DE gamma-GTP; CRP; Japanese men; non-overweight subjects; overweight
   subjects
ID C-REACTIVE PROTEIN; TYPE-2 DIABETES-MELLITUS; INSULIN-RESISTANCE
   ATHEROSCLEROSIS; ARTERY RISK DEVELOPMENT; CORONARY-HEART-DISEASE;
   YOUNG-ADULTS CARDIA; GLUTAMYL-TRANSFERASE; METABOLIC SYNDROME; OXIDATIVE
   STRESS; CARDIOVASCULAR-DISEASE
AB The relationship between gamma-glutamyltransferase (gamma-GTP) and C-reactive protein (CRP) has not been established, particularly in the lean or non-overweight population. In the present study, we examined the associations between gamma-GTP and CRP in non-overweight and overweight middle-aged Japanese men. We conducted a cross-sectional study of 4,271 apparently healthy men aged 40 to 64 y (mean +/- SD, 50.5 +/- 6.6 y) who participated in health checkups. Associations between serum CRP levels, other clinical parameters, and lifestyle factors were analyzed using Spearman's rank correlation coefficient analysis and multiple linear regression analysis in the non-overweight (body mass index [BMI]<25 kg/ m(2)) and overweight (BMI >= 25 kg/m(2)) men. Associations between serum gamma-GTP activity and serum CRP levels were analyzed using analysis of covariance by comparisons of serum CRP levels of four subgroups according to gamma-GTP status. In non-overweight men, Bla high-density lipoprotein cholesterol, triacylglycerols, fasting blood glucose, aspartate aminotransferase, gamma-GTP, and smoking habit were positively associated with serum CRP levels. In overweight men, BMI, diastolic blood pressure, triacylglycerols, and gamma-GTP were positively associated with serum CRP levels. After adjustment for age, BMI, smoking status, and alcohol intake, dose-response relationships were observed between gamma-GTP and CRP levels in both overweight and non-overweight men. The results of this study indicate that an increase in serum gamma-GTP activity is closely associated with elevated CRP levels in both non-overweight and overweight middle-aged Japanese men.
C1 [Sunto, Akiko; Mochizuki, Kazuki; Miyauchi, Rie; Misaki, Yasumi; Shimada, Masaya; Goda, Toshinao] Univ Shizuoka, Grad Sch Nutr & Environm Sci, Lab Nutrit Physiol, Shizuoka 4228526, Japan.
   [Sunto, Akiko; Mochizuki, Kazuki; Miyauchi, Rie; Misaki, Yasumi; Shimada, Masaya; Goda, Toshinao] Univ Shizuoka, Grad Sch Nutr & Environm Sci, Global COE Program, Shizuoka 4228526, Japan.
   [Kasezawa, Nobuhiko; Tohyama, Kazushige] SBS Shizuoka Hlth Promot Ctr, Shizuoka 4228670, Japan.
C3 University of Shizuoka; University of Shizuoka
RP Goda, T (corresponding author), Univ Shizuoka, Grad Sch Nutr & Environm Sci, Lab Nutrit Physiol, Shizuoka 4228526, Japan.
EM gouda@u-shizuoka-ken.ac.jp
RI Goda, Toshinao/C-8981-2014
FU Ministry of Education, Culture, Sports, Science and Technology (MEXT) of
   Japan and the Global COE program [23300276]; Center of Excellence for
   Innovation in Human Health Sciences, of MEXT; Grants-in-Aid for
   Scientific Research [23300276] Funding Source: KAKEN
FX This study was financially supported by a Grant-inAid for Scientific
   Research (23300276) from the Ministry of Education, Culture, Sports,
   Science and Technology (MEXT) of Japan and the Global COE program, the
   Center of Excellence for Innovation in Human Health Sciences, of MEXT.
   We thank Drs. S. Sasaki and K. Murakami for providing the brief
   self-administered diet history questionnaire and for helpful
   discussions.
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NR 42
TC 6
Z9 6
U1 0
U2 2
PU CENTER ACADEMIC PUBL JAPAN
PI TOKYO
PA 2-4-16 YAYOI, BUNKYO-KU, TOKYO, 113-0032, JAPAN
SN 0301-4800
J9 J NUTR SCI VITAMINOL
JI J. Nutr. Sci. Vitaminol.
PD APR
PY 2013
VL 59
IS 2
BP 108
EP 114
DI 10.3177/jnsv.59.108
PG 7
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 152MO
UT WOS:000319536000005
PM 23727640
OA gold
DA 2025-06-11
ER

PT J
AU Solari, NEF
   Inzaugarat, ME
   Baz, P
   De Matteo, E
   Lezama, C
   Galoppo, M
   Galoppo, C
   Cherñavsky, AC
AF Ferreyra Solari, Nazarena E.
   Eugenia Inzaugarat, Maria
   Baz, Placida
   De Matteo, Elena
   Lezama, Carol
   Galoppo, Marcela
   Galoppo, Cristina
   Chernavsky, Alejandra C.
TI The Role of Innate Cells Is Coupled to a Th1-Polarized Immune Response
   in Pediatric Nonalcoholic Steatohepatitis
SO JOURNAL OF CLINICAL IMMUNOLOGY
LA English
DT Article
DE Memory and naive T cell subsets; polymorphonuclear cells; oxidative
   stress; Th1/Th2 cytokines; pediatric NASH
ID RECEPTOR EXPRESSION; NATURAL-HISTORY; LIVER-DISEASE; LEPTIN;
   LYMPHOCYTES; POPULATIONS; INTERFERON; ACTIVATION; MECHANISMS; FIBROSIS
AB Background Nonalcoholic steatohepatitis (NASH) is a chronic inflammatory liver disease influenced by risk factors for the metabolic syndrome. In adult patients, NASH is associated with an altered phenotype and functionality of peripheral immune cells, the recruitment of leukocytes and intrahepatic activation, and an exacerbated production of reactive oxygen species (ROS) and cytokines. It remains unclear if the previously described differences between pediatric and adult nonalcoholic fatty liver diseases also reflect differences in their pathogenesis.
   Aims We aimed to investigate the phenotype and functionality of circulating immune cells and the potential contribution of liver infiltrating leukocytes to the immunological imbalance in pediatric NASH.
   Results By a real-time PCR-based analysis of cytokines and immunohistochemical staining of liver biopsies, we demonstrated that the hepatic microenvironment is dominated by interferon-gamma (IFN-gamma) but not interleukin-4 and is infiltrated by a higher number of CD8(+) cells in pediatric NASH. The number of infiltrating neutrophils positively correlated with ROS generation by peripheral polymorphonuclear cells. By a flow cytometric analysis of peripheral blood lymphocytes, a distinctive increase in CD8(+) CD45RO and CD8+ CD45RA subpopulations and an increased production of IFN-gamma by CD4(+) and CD8(+) cells were shown. The production of ROS following PMA stimulation was augmented in circulating neutrophils but not in monocytes.
   Conclusion In sum, the distinctive phenotype and functionality of infiltrating and circulating cells suggest that the role of innate cells is coupled to a Th1-polarized immune response in pediatric NASH.
C1 [Ferreyra Solari, Nazarena E.; Eugenia Inzaugarat, Maria; Baz, Placida; Chernavsky, Alejandra C.] Univ Buenos Aires, Lab Inmunogenet, Hosp Clin Jose de San Martin, Buenos Aires, DF, Argentina.
   [De Matteo, Elena] Univ Buenos Aires, Serv Patol, Hosp Ninos Dr R Gutierrez, Buenos Aires, DF, Argentina.
   [Lezama, Carol; Galoppo, Marcela; Galoppo, Cristina] Univ Buenos Aires, Unidad Hepatol, Hosp Ninos Dr Ricardo Gutierrez, Buenos Aires, DF, Argentina.
C3 University of Buenos Aires; University of Buenos Aires Hospital;
   Hospital de Ninos Doctor Ricardo Gutierrez; University of Buenos Aires;
   University of Buenos Aires; University of Buenos Aires Hospital;
   Hospital de Ninos Doctor Ricardo Gutierrez
RP Cherñavsky, AC (corresponding author), Univ Buenos Aires, Lab Inmunogenet, Hosp Clin Jose de San Martin, Av Cordoba 2351,3Er Piso,CP1120, Buenos Aires, DF, Argentina.
EM accher@fibertel.com.ar
OI Inzaugarat, Maria Eugenia/0000-0001-9500-0123
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NR 43
TC 64
Z9 66
U1 0
U2 9
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0271-9142
EI 1573-2592
J9 J CLIN IMMUNOL
JI J. Clin. Immunol.
PD JUN
PY 2012
VL 32
IS 3
BP 611
EP 621
DI 10.1007/s10875-011-9635-2
PG 11
WC Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology
GA 968LE
UT WOS:000305982100024
PM 22228550
DA 2025-06-11
ER

PT J
AU Targher, G
   Kendrick, J
   Smits, G
   Chonchol, M
AF Targher, G.
   Kendrick, J.
   Smits, G.
   Chonchol, M.
TI Relationship between serum gammaglutamyltransferase and chronic kidney
   disease in the United States adult population. Findings from the
   National Health and Nutrition Examination Survey 2001-2006
SO NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
LA English
DT Article
DE Gamma-glutamyltransferase; Liver enzymes; Chronic kidney disease;
   Epidemiology
ID GAMMA-GLUTAMYL-TRANSFERASE; FATTY LIVER-DISEASE; CARDIOVASCULAR-DISEASE;
   OXIDATIVE STRESS; RENAL-INSUFFICIENCY; INSULIN-RESISTANCE; METABOLIC
   SYNDROME; MORTALITY RISK; HEART; PREVALENCE
AB Background and aims: Elevated serum levels of gamma-glutamyltransferase (GGT) are a marker of liver injury, but may also be associated with other diseases and death. Currently, the association of serum GGT concentrations with chronic kidney disease has not been established in the U.S. general population.
   Methods and results: We performed a cross-sectional analysis of data from the National Health and Nutrition Examination Survey 2001 through 2006 and examined the association between serum GGT concentrations and chronic kidney disease in a nationally representative sample of 13,188 adults aged 20 years or older. Glomerular filtration rate (eGFR) was estimated using the Modification of Diet in Renal Disease formula. The prevalence of chronic kidney disease defined as eGFR <60 ml/min/1.73 m(2) or abnormal albuminuria in those with eGFR > 60 ml/min/1.73 m(2) was 13.9% (n = 1842). Serum GGT elevation was associated with an increased odds of chronic kidney disease (odds ratio 2.38, 95% confidence intervals 2.02-2.80, p < 0.0001). After adjustment for demographics, comorbidities, daily alcohol consumption, lipid-lowering medications, viral hepatitis status and laboratory measures, the odds ratio of chronic kidney disease per log serum GGT increase was 1.79 (1.41, 2.27; p< 0.0001).
   Conclusions: These results show a strong, independent, relationship of increased serum GGT concentrations with chronic kidney disease in the US adult population. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Targher, G.] Univ Verona, Osped Civile Maggiore, Endocrinol Sect, Dept Biomed & Surg Sci, I-37126 Verona, Italy.
   [Kendrick, J.; Smits, G.; Chonchol, M.] Univ Colorado Denver & Hlth Sci Ctr, Div Renal Dis & Hypertens, Denver, CO USA.
C3 University of Verona; University of Colorado System; University of
   Colorado Anschutz Medical Campus
RP Targher, G (corresponding author), Univ Verona, Osped Civile Maggiore, Endocrinol Sect, Dept Biomed & Surg Sci, Piazzale Stefani 1, I-37126 Verona, Italy.
EM giovanni.targher@univr.it
RI Targher, Giovanni/AAB-9008-2019
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   National Center for Health Statistics, National Health and Nutrition Examination Survey: questionnaires, datasets, and related documentation
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NR 38
TC 52
Z9 54
U1 0
U2 6
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0939-4753
EI 1590-3729
J9 NUTR METAB CARDIOVAS
JI Nutr. Metab. Carbiovasc. Dis.
PD OCT
PY 2010
VL 20
IS 8
BP 583
EP 590
DI 10.1016/j.numecd.2009.05.012
PG 8
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism; Nutrition
   & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism;
   Nutrition & Dietetics
GA 705LC
UT WOS:000286128900005
PM 19699624
DA 2025-06-11
ER

PT J
AU Zerrad-Saadi, A
   Therond, P
   Chantepie, S
   Couturier, M
   Rye, KA
   Chapman, MJ
   Kontush, A
AF Zerrad-Saadi, Amal
   Therond, Patrice
   Chantepie, Sandrine
   Couturier, Martine
   Rye, Kerry-Anne
   Chapman, M. John
   Kontush, Anatol
TI HDL3-Mediated Inactivation of LDL-Associated Phospholipid Hydroperoxides
   Is Determined by the Redox Status of Apolipoprotein A-I and HDL Particle
   Surface Lipid Rigidity Relevance to Inflammation and Atherogenesis
SO ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
LA English
DT Article
DE small dense HDL; surface rigidity; methionine residues; reduction;
   apolipoprotein AI; lipid hydroperoxides
ID HIGH-DENSITY-LIPOPROTEIN; ACTIVATING-FACTOR ACETYLHYDROLASE; PERFORMANCE
   LIQUID-CHROMATOGRAPHY; ELEVATED OXIDATIVE STRESS; ESTER TRANSFER
   PROTEIN; HUMAN-SERUM; DIFFERENT CONSTITUENTS; ANTIOXIDATIVE ACTIVITY;
   INTERSTITIAL FLUID; METABOLIC SYNDROME
AB Objectives-Small dense HDL3 particles of defined lipidome and proteome potently protect atherogenic LDL against free radical-induced oxidation; the molecular determinants of such antioxidative activity in these atheroprotective, antiinflammatory particles remain indeterminate.
   Methods and Results-Formation of redox-active phosphatidylcholine hydroperoxides (PCOOH) and redox-inactive phosphatidylcholine hydroxides (PCOH) was initiated in LDL by free radical-induced oxidation. Human HDL3 inactivated LDL-derived PCOOH (-62%, P<0.01) and enhanced accumulation of PCOH (2.1-fold, P<0.05); in parallel, HDL3 accumulated minor amounts of PCOOH. Enzyme-deficient reconstituted dense HDL potently inactivated PCOOH (-43%, P<0.01). HDL3-mediated reduction of PCOOH to PCOH occurred concomitantly with oxidation of methionine residues in HDL3-apolipoprotein AI (apoAI). Preoxidation of methionine residues by chloramine T markedly attenuated PCOOH inactivation (-35%); by contrast, inhibition of HDL3-associated enzymes was without effect. PCOOH transfer rates from oxidized LDL to phospholipid liposomes progressively decreased with increment in the rigidity of the phospholipid monolayer.
   Conclusions-The redox status of apoAI and surface lipid rigidity represent major determinants of the potent HDL3-mediated protection of LDL against free radical-induced oxidation. Initial transfer of PCOOH to HDL3 is modulated by the surface rigidity of HDL3 particles with subsequent reduction of PCOOH to PCOH by methionine residues of apoAI. (Arterioscler Thromb Vasc Biol. 2009;29:2169-2175.)
C1 [Zerrad-Saadi, Amal; Chantepie, Sandrine; Couturier, Martine; Chapman, M. John; Kontush, Anatol] Hop Pitie, INSERM, Natl Inst Hlth & Med Res, Dyslipidemia & Atherosclerosis Res Unit,UMRS 939, F-75651 Paris 13, France.
   [Zerrad-Saadi, Amal; Chantepie, Sandrine; Couturier, Martine; Chapman, M. John; Kontush, Anatol] Univ Paris 06, F-75252 Paris 05, France.
   [Zerrad-Saadi, Amal; Therond, Patrice; Couturier, Martine] Univ Paris 05, Dept Biochem, Paris, France.
   [Rye, Kerry-Anne] Heart Res Inst, Sydney, NSW, Australia.
C3 Assistance Publique Hopitaux Paris (APHP); Hopital Universitaire
   Pitie-Salpetriere - APHP; Sorbonne Universite; Institut National de la
   Sante et de la Recherche Medicale (Inserm); Sorbonne Universite;
   Universite Paris Cite; University of Sydney; Heart Research Institute
RP Kontush, A (corresponding author), Hop Pitie, INSERM, U939, Pavillon Benjamin Delessert,83 Blvd Hop, F-75651 Paris 13, France.
EM kontush@chups.jussieu.fr
RI Kontush, Anatol/J-2198-2016; chapman, john/Y-2742-2019
OI Kontush, Anatol/0000-0002-9008-7335; zerrad-saadi zerrad amal,
   Amal/0000-0002-8577-5133; CHANTEPIE-LABORDE,
   Sandrine/0000-0003-1652-432X
FU National Institute for Health and Medical Research (INSERM); Agence
   Nationale de Recherche; Fondation pour la Recherche Medicale; Nouvelle
   Societe Francaise d'Atherosclerose; Schering-Plough (France); Assistance
   Publique - Hopitaux de Paris/INSERM (France)
FX These studies were supported by National Institute for Health and
   Medical Research (INSERM), Agence Nationale de Recherche (France;
   project COD 2005 Lisa) and the Fondation pour la Recherche Medicale. A.
   Z. gratefully acknowledges support from Nouvelle Societe Francaise
   d'Atherosclerose, MSD and Schering-Plough (France). M. J. C. and A. K.
   acknowledge the award of a Contrat d'Interface from Assistance Publique
   - Hopitaux de Paris/INSERM (France).
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NR 52
TC 134
Z9 144
U1 1
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1079-5642
EI 1524-4636
J9 ARTERIOSCL THROM VAS
JI Arterioscler. Thromb. Vasc. Biol.
PD DEC
PY 2009
VL 29
IS 12
BP 2169
EP U420
DI 10.1161/ATVBAHA.109.194555
PG 34
WC Hematology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Hematology; Cardiovascular System & Cardiology
GA 521TO
UT WOS:000271947300030
PM 19762782
OA Bronze
DA 2025-06-11
ER

PT J
AU Peterson, JM
   Bryner, RW
   Frisbee, JC
   Alway, SE
AF Peterson, Jonathan M.
   Bryner, Randall W.
   Frisbee, Jefferson C.
   Alway, Stephen E.
TI Effects of exercise and obesity on UCP3 content in rat hindlimb muscles
SO MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
LA English
DT Article
DE citrate synthase; aerobic training; fatty acids; uncoupling protein 3;
   metabolic syndrome
ID OXIDATIVE STRESS
AB Uncoupling protein 3 (UCP3) is a mitochondrial inner membrane protein, which is hypothesized to shuttle nonmetabolized fatty acids. Particularly when excessive fatty acids are present. Purpose: Obese Zucker rats (OZR) have systematically elevated levels of fatty acids, with decreased fatty acid metabolism. We hypothesized that basal UCP3 protein expression levels would be elevated in the skeletal muscles of the OZR compared with the lean Zucker rats (LZR). In addition, because aerobic exercise training has been shown to elevate the ability of skeletal muscle to metabolize lipids, we also hypothesized that aerobic exercise training would decrease skeletal Muscle UCP3 protein expression and that this would be more pronounced in the skeletal muscles of the OZR. Methods: OZR and LZR were aerobically trained on a motorized treadmill for 55 min.d(-1). 5 d.wk(-1). for 9 wk. UCP3 and oxidative enzymes were measured in plantaris, gastrocnemius, and soleus muscles. Results: Basal UCP3 protein expression was elevated approximately eightfold in the plantaris Muscles and threefold in the gastrocnemius muscles of the OZR compared with the LZR (P < 0.05). However, there was no difference in UCP3 protein expression in the soleus muscles of the OZR compared with the LZR (P 0.34). Furthermore, aerobic exercise training did not significantly after UCP3 protein expression in the soleus, plantaris. or gastrocnemius muscles of the LZR: however, UCP3 protein expression levels decreased in trained OZR soleus and gastrocnemius muscles compared with controls. Conclusions: The decrease in UCP3 with aerobic exercise training was most notable in the soleus of the OZR. These data demonstrate that the exercise-induced adaptations of UCP-33 protein levels are muscle specific in obese animals compared with lean animals.
C1 [Peterson, Jonathan M.; Bryner, Randall W.; Alway, Stephen E.] W Virginia Univ, Robert C Byrd Hlth Sci Ctr, Sch Med, Div Exercise Physiol,Lab Muscle Biol & Sarcopenia, Morgantown, WV 26506 USA.
   [Frisbee, Jefferson C.] W Virginia Univ, Robert C Byrd Hlth Sci Ctr, Sch Med, Ctr Interdisciplinary Res Cardiovasc Sci,Dept Phy, Morgantown, WV 26506 USA.
C3 West Virginia University; West Virginia University
RP Bryner, RW (corresponding author), W Virginia Univ, Robert C Byrd Hlth Sci Ctr, Sch Med, Div Exercise Physiol,Lab Muscle Biol & Sarcopenia, Morgantown, WV 26506 USA.
EM rbryner@hsc.wvu.edu
RI Peterson, Jonathan/H-3122-2019; Alway, Stephen/AAF-8834-2020
OI Frisbee, Jefferson/0000-0003-2751-0599; Alway,
   Stephen/0000-0002-0378-4707; Peterson, Jonathan/0000-0002-9873-3880
FU West Virginia University School of Medicine Research and Development
FX This project was funded in part by a West Virginia University School of
   Medicine Research and Development grant to RWB. The results of the
   present study do not constitute endorsement by the American College of
   Sports Medicine.
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NR 48
TC 10
Z9 10
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0195-9131
EI 1530-0315
J9 MED SCI SPORT EXER
JI Med. Sci. Sports Exerc.
PD SEP
PY 2008
VL 40
IS 9
BP 1616
EP 1622
DI 10.1249/MSS.0b013e31817702a4
PG 7
WC Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Sport Sciences
GA 348MM
UT WOS:000259214600009
PM 18685530
OA Bronze
DA 2025-06-11
ER

PT J
AU Cheyssac, C
   Dina, C
   Leprêtre, F
   Vasseur-Delannoy, V
   Dechaume, A
   Lobbens, S
   Balkau, B
   Ruiz, J
   Charpentier, G
   Pattou, F
   Joly, E
   Prentki, M
   Hansen, T
   Pedersen, O
   Vaxillaire, M
   Frogruel, P
AF Cheyssac, C
   Dina, C
   Leprêtre, F
   Vasseur-Delannoy, V
   Dechaume, A
   Lobbens, S
   Balkau, B
   Ruiz, J
   Charpentier, G
   Pattou, F
   Joly, E
   Prentki, M
   Hansen, T
   Pedersen, O
   Vaxillaire, M
   Frogruel, P
TI EIF4A2 is a positional candidate gene at the 3q27 locus linked to type 2
   diabetes in French families
SO DIABETES
LA English
DT Article
ID SINGLE NUCLEOTIDE POLYMORPHISM; SUSCEPTIBILITY GENES; INSULIN
   SENSITIVITY; ONSET; YOUNG; METABOLISM; RESISTANCE; SEARCH; RISK; ACID
AB One of the most replicated loci influencing type 2 diabetes-related quantitative traits (quantitative trait loci [QTL]) is on chromosome 3q27 and modulates both type 2 diabetes- and metabolic syndrome-associated phenotypes. A QTL for type 2 diabetes age (if onset (logarithm of odds [LOD] score = 3.01 at D3S3686, P = 0.0001) was identified in a set of French families. To assess genetic variation underlying both age-of-onset QTL and our previous type 2 diabetes linkage in a 3.87-Mb interval, we explored 36 single nucleotide polymorphisms (SNPs) in two biologically relevant candidate genes for glucose homeostasis, kininogen (KNG1), and eukaryotic translation initiation factor 4 alpha 2 (EIF4A2). Analysis of 148 families showed significant association of a frequent SNP, rs266714, located 2.47 kb upstream of EIF4A2, with familial type 2 diabetes (family-based association test, P = 0.0008) and early age of onset (P = 0.0008). This SNP also contributes to both age-of-onset QTL (1.13 LOD score decrease P = 0.02) and type 2 diabetes linkage (genotype identical-by-descent sharing test, P = 0.02). However, no association was observed in three independent European diabetic cohorts. EIF4A2 controls specific mRNA translation and protein synthesis rate in pancreatic P-cells, and our data indicates that EIF4A2 is downregulated by high glucose in rat beta-INS832/13 cells. The potential role of EIF4A2 in glucose homeostasis and its putative contribution to type 2 diabetes in the presence of metabolic stress will require further investigation.
C1 Inst Pasteur, UMR 8090, Inst Biol, CNRS, 1 Rue Prof Calmette,BP 245, F-59019 Lille, France.
   INSERM U258, IFR69, Villejuif, France.
   CHUV BH 19, Div Endocrinol Diabetol & Metab, Lausanne, Switzerland.
   Ctr Hosp Sud Francilien, Diabetol Unit, Corbeil Essonnes, France.
   CHU Lille, INSERM, ERITM 0106, F-59037 Lille, France.
   Univ Montreal, Dept Nutr, Mol Nutr Unit, CHUM,Ctr Rech, Montreal, PQ H3C 3J7, Canada.
   Steno Diabet Ctr, DK-2820 Gentofte, Denmark.
   Hagedorn Res Inst, Gentofte, Denmark.
   Imperial Coll, Sect Genom Med, London, England.
C3 Centre National de la Recherche Scientifique (CNRS); Pasteur Network;
   Universite de Lille; Institut Pasteur Lille; Institut National de la
   Sante et de la Recherche Medicale (Inserm); University of Lausanne;
   Centre Hospitalier Universitaire Vaudois (CHUV); Centre Hospitalier Sud
   Francilien; Universite de Lille; CHU Lille; Institut National de la
   Sante et de la Recherche Medicale (Inserm); Universite de Montreal;
   Steno Diabetes Center; Novo Nordisk; Hagedorn Research Institute;
   Imperial College London
RP Inst Pasteur, UMR 8090, Inst Biol, CNRS, 1 Rue Prof Calmette,BP 245, F-59019 Lille, France.
EM vaxillaire@good.ibl.fr
RI Pedersen, Oluf/AAG-8015-2020; Hansen, Torben/J-8065-2012; Prentki,
   Marc/LBI-2401-2024; Dina, Christian/D-3535-2015; Froguel,
   Philippe/O-6799-2017; Pattou, Francois/O-6151-2017
OI lepretre, frederic/0000-0002-5249-3930; Froguel,
   Philippe/0000-0003-2972-0784; Hansen, Torben/0000-0001-8748-3831; Dina,
   Christian/0000-0002-7722-7348; Pattou, Francois/0000-0001-8388-3766;
   Pedersen, Oluf/0000-0002-3321-3972
FU Medical Research Council [G0000477] Funding Source: Medline; MRC
   [G0000477] Funding Source: UKRI
CR Abecasis GR, 2002, NAT GENET, V30, P97, DOI 10.1038/ng786
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NR 25
TC 18
Z9 19
U1 0
U2 0
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0012-1797
EI 1939-327X
J9 DIABETES
JI Diabetes
PD APR
PY 2006
VL 55
IS 4
BP 1171
EP 1176
DI 10.2337/diabetes.55.04.06.db05-1298
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 028MK
UT WOS:000236491400040
PM 16567544
OA Bronze
DA 2025-06-11
ER

PT J
AU Dzien, A
   Dzien-Bischinger, C
   Hoppichler, F
   Lechleitner, M
AF Dzien, A
   Dzien-Bischinger, C
   Hoppichler, F
   Lechleitner, M
TI The metabolic syndrome as a link between smoking and cardiovascular
   disease
SO DIABETES OBESITY & METABOLISM
LA English
DT Article
DE insulin resistance; smoking
ID CORONARY-ARTERY DISEASE; INSULIN-RESISTANCE; CIGARETTE-SMOKING;
   ENDOTHELIAL DYSFUNCTION; OXIDATIVE STRESS; HYPERINSULINEMIA;
   SENSITIVITY; MARKERS; ATHEROSCLEROSIS; INTERVENTION
AB Objective: Smoking is associated with a significant increase in the cardiovascular risk. The possible relationship of smoking with insulin resistance might further enhance the cardiovascular risk of the patients and is therefore of great clinical interest.
   Design, Setting and Subjects: We have retrospectively evaluated data of 3804 non-diabetic men attending a medical outdoor clinic. Clinical [body mass index (BMI), percentage of body fat, waist-to-hip ratio] and laboratory results were compared between smokers (n = 124) and non-smokers (n = 1915) without cardiovascular disease, as well as between smokers (n = 759) and non-smokers (n = 1006) with cardiovascular disease.
   Results: Smokers without clinically manifest cardiovascular disease revealed significantly higher fasting glucose (5.8 +/- 0.6 mmol/l) and triglyceride levels (1.8 +/- 0.9 mmol/l) than non-smokers (fasting glucose: 5.1 +/- 0.7 mmol/l, p < 0.010; triglycerides: 1.5 +/- 0.8 mmol/l, p < 0.030). The adverse metabolic profile of smokers was even more pronounced in patients with cardiovascular disease. An age-matched analysis of smokers could demonstrate that cardiovascular patients revealed higher BMI values (27.3 +/- 2.4 kg/m(2)) and a higher percentage of body fat (25.5 +/- 5.5%) than those without cardiovascular disease (BMI: 25.7 +/- 2.2 kg/m(2), p < 0.010; percentage of body fat: 23.0 +/- 5.5%, p < 0.030).
   Conclusion: In men with and without clinically manifest cardiovasular disease, smoking was associated with a metabolic profile indicating a higher degree of insulin resistance.
C1 Univ Innsbruck Hosp, Dept Internal Med, A-6020 Innsbruck, Austria.
   Med Ctr Hentschelhof, Innsbruck, Austria.
   Hosp Barmherzige Brueder, Salzburg, Austria.
C3 Medical University of Innsbruck; University of Innsbruck Hospital;
   Konventhospital Der Barmherzigen Bruder
RP Univ Innsbruck Hosp, Dept Internal Med, Anichstr 35, A-6020 Innsbruck, Austria.
EM monika.lechleitner@uibk.ac.at
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NR 33
TC 42
Z9 44
U1 0
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1462-8902
EI 1463-1326
J9 DIABETES OBES METAB
JI Diabetes Obes. Metab.
PD MAR
PY 2004
VL 6
IS 2
BP 127
EP 132
DI 10.1111/j.1462-8902.2004.00324.x
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 766YF
UT WOS:000188410800006
PM 14746578
DA 2025-06-11
ER

PT J
AU Jennen, C
   Uhlenbruck, G
AF Jennen, Christiane
   Uhlenbruck, Gerhard
TI Exercise and Life-Satisfactory-Fitness: Complementary Strategies in the
   Prevention and Rehabilitation of Illnesses
SO EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Review
DE exercise; fitness; grandchildren; health-satisfaction; leisure time
   activity; life-contentedness; wellness
AB Moderate training of an endurance nature, but also other exercise activities, not only has a preventive effect on various illnesses and pre-illness states such as the metabolic syndrome and cancer, but is also effective in treating patients in the rehabilitation phase after illness, e. g. cardiovascular or cancer. Our investigation demonstrates that even low level physical activity has a very good preventive effect too, which is enhanced when it is accompanied by mental activity and psychological well-being. In total, we investigated 13 000 people on the basis of socio-economic panel polls with respect to life contentment, health status and leisure-time activities. Life contentment is positively linked to contentment with labor, which seems to be an essential aspect with regard to the increasing number of unemployed people in Europe. The second important factor is health-promoting activities during leisure time. Exercise, especially, has a significant influence on life satisfaction as a feeling of physical fitness feeling is regarded as synonymous with good health. The results underline the psycho-neuroimmunological network, which stabilizes our health and shows that different activities in older adults have a significant effect on the aging process and age-related illnesses. Besides the various activities that are important in this arena, namely muscle and mental mobility ('brawn and brain'), a third component must be taken into consideration: life contentment in the form of a successful retrospective view and a positive outlook, embedded in a psychosocial family environment ('brood') and integrated in a stress-free biotope, where life does make sense. Alternative and complementary strategies should be considered in light of these three aspects when we think about additional anti-inflammatory strategies in preventing diseases or treating them and their relapses.
C1 [Jennen, Christiane; Uhlenbruck, Gerhard] Univ Cologne, Inst Immunobiol, D-50924 Cologne, Germany.
C3 University of Cologne
RP Jennen, C (corresponding author), Univ Cologne, Inst Immunobiol, D-50924 Cologne, Germany.
EM christianejennen@gmx.de
FU Deutsche Forschungsgemeinschaft
FX The project was sponsored by Deutsche Forschungsgemeinschaft and
   supervised by Infratest, Munich. The data were kindly given to us by
   Prof. Dr Gert Wagner, German Institute for Economical Research, Berlin.
   We are greatly indebted to him for this generous help and for his
   friendly advice.
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NR 16
TC 7
Z9 9
U1 0
U2 8
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1741-427X
J9 EVID-BASED COMPL ALT
JI Evid.-based Complement Altern. Med.
PY 2004
VL 1
IS 2
BP 157
EP 165
DI 10.1093/ecam/neh021
PG 9
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA V06FI
UT WOS:000207179100006
PM 15480441
OA Green Published, Green Submitted, hybrid
DA 2025-06-11
ER

PT J
AU Bai, Y
   Fang, XY
   Jiang, YP
   Xu, JH
   Wu, LL
   Li, Q
   Cao, FL
   Zhao, LG
AF Bai, Yun
   Fang, Xianying
   Jiang, Yunpeng
   Xu, Jiahui
   Wu, Lulu
   Li, Qi
   Cao, Fuliang
   Zhao, Linguo
TI Sequential fermentation of Ginkgo biloba seeds by Bacillus
   subtilis natto and Lactobacillus plantarum enhanced
   nutrition, flavor and lipid-lowering activity
SO JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
LA English
DT Article
DE Gingko biloba seeds; solid-state fermentation; toxicity reduction;
   flavor; lipid-lowering
ID 4'-O-METHYLPYRIDOXINE; GROWTH
AB BACKGROUND Ginkgo biloba seeds (GBS) are rich in flavonoids, proteins and reducing sugar, and have been consumed as food and medicinal nuts for thousands of years. However, the presence of ginkgotoxins and their poor palatability limit people's consumption of them. RESULTS This study used solid-state fermentation with Bacillus subtilis natto and Lactobacillus plantarum to enhance the safety and benefits of GBS. Optimized fermentation conditions increased the content of beneficial components like total flavonoids, soluble protein and reducing sugar while eliminating unpleasant odors (isoamyl aldehyde and hexanal) and reducing the toxin 4 '-O-methylpyridoxine by 91.17%. Fermentation of GBS powder can significantly enhance its anti-inflammatory and antioxidant activities in vitro (P < 0.001). Furthermore, it exhibits a dose-dependent effect within a certain concentration range. Mixed fermentation (FBnLp) was evaluated for its effects on obesity and metabolic syndrome in mice fed a high-fat diet. FBnLp significantly reduced body and liver weight gain, prevented dyslipidemia and decreased inflammatory and oxidative stress compared to unfermented GBS. Histological analysis showed that FBnLp improved liver health by reducing fat accumulation and preventing non-alcoholic fatty liver disease. Meanwhile, it was found that feeding FBnLp increased the expression of CPT-1 alpha, which regulates energy expenditure and fat breakdown, and downregulated the expression of SREBP-1c, FAS and ACC, which regulate fat synthesis. CONCLUSION This research provides new insights and technological support for the application and development of FBnLp as a functional product, addressing key issues in its use and industry growth. (c) 2024 Society of Chemical Industry.
C1 [Bai, Yun; Fang, Xianying; Jiang, Yunpeng; Xu, Jiahui; Wu, Lulu; Li, Qi; Zhao, Linguo] Nanjing Forestry Univ, Jiangsu Coinnovat Ctr Efficient Proc & Utilizat Fo, Nanjing, Peoples R China.
   [Bai, Yun; Fang, Xianying; Jiang, Yunpeng; Xu, Jiahui; Wu, Lulu; Li, Qi; Zhao, Linguo] Nanjing Forestry Univ, Coll Chem Engn, Nanjing 210037, Peoples R China.
   [Bai, Yun; Fang, Xianying; Zhao, Linguo] Nanjing Forestry Univ, Jinpu Res Inst, Nanjing, Peoples R China.
   [Cao, Fuliang] Nanjing Forestry Univ, Coinnovat Ctr Sustainable Forestry Southern China, Nanjing 210037, Peoples R China.
C3 Nanjing Forestry University; Nanjing Forestry University; Nanjing
   Forestry University; Nanjing Forestry University
RP Zhao, LG (corresponding author), Nanjing Forestry Univ, Coll Chem Engn, Nanjing 210037, Peoples R China.; Cao, FL (corresponding author), Nanjing Forestry Univ, Coinnovat Ctr Sustainable Forestry Southern China, Nanjing 210037, Peoples R China.
EM fuliangcaonjfu@163.com; njfu2304@163.com
FU Jiangsu 333 Project of Cultivation of Highlevel Talents [LYKJ[2024]01];
   Jiangsu Forestry Science and Technology Innovation and Extension Project
   [BRA2015317]; Jiangsu '333' Project of Cultivation of High-Level Talents
FX This work was supported by the Jiangsu Forestry Science and Technology
   Innovation and Extension Project (LYKJ[2024]01) and the Jiangsu '333'
   Project of Cultivation of High-Level Talents (grant no. BRA2015317).
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   Zou MM, 2021, J SCI FOOD AGR, V101, P1782, DOI 10.1002/jsfa.10792
NR 43
TC 2
Z9 2
U1 13
U2 18
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-5142
EI 1097-0010
J9 J SCI FOOD AGR
JI J. Sci. Food Agric.
PD MAR 15
PY 2025
VL 105
IS 4
BP 2607
EP 2620
DI 10.1002/jsfa.14033
EA NOV 2024
PG 14
WC Agriculture, Multidisciplinary; Chemistry, Applied; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture; Chemistry; Food Science & Technology
GA W9Z2T
UT WOS:001358181000001
PM 39540367
DA 2025-06-11
ER

PT J
AU Wang, SQ
   Xu, SM
   Wang, S
   Fang, WH
   Shi, WR
AF Wang, Shuqin
   Xu, Senmao
   Wang, Sui
   Fang, Wenhao
   Shi, Wanrong
TI Risk factors and lipid metabolism characteristics of early-onset male
   androgenetic alopecia: A pilot study
SO JOURNAL OF COSMETIC DERMATOLOGY
LA English
DT Article
DE androgenetic alopecia; ceramide; lipid; risk factor
ID DERMAL PAPILLA CELLS; OXIDATIVE STRESS; ASSOCIATION
AB Background: Male androgenetic alopecia (MAA) is a multifactorial disease, with patients presenting at a younger age, which is a risk factor for many metabolic diseases. Aims: To explore the risk factors associated with early-onset of MAA and its metabolic characteristics. Methods: Forty patients with MAA and 45 healthy controls were collected. The serum levels of fasting blood glucose (FBG), total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), total testosterone (TT), uric acid (UA), and 25-hydroxyvitamin D (25(OH)D) were measured. Meanwhile, lipid metabolites were detected by ultra-high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS). Results: 37.50% MAA patients had metabolic syndrome, compared to 17.78% in control group (p < 0.05). The levels of HDL-C, UA, and 25(OH)D were decreased in patients with MAA compared to healthy controls (p < 0.05). However, there was no significant difference in the level of TT between the two groups. Additionally, there were no significant differences in the levels of HDL-C, UA, 25(OH)D, and TT among different grades of hair loss (p > 0.05). The lipid profile of early-onset MAA differed significantly from healthy controls. In early-onset MAA, the levels of ceramide (Cer) and sphingomyelin (SM) were significantly lower. Cer(d38:5) and TG(15:0/18:1/18:1) may be the biomarkers. Conclusion: Low HDL-C, UA, and 25(OH)D may be the independent risk factors for early-onset MAA. Abnormal lipid metabolism was observed in early-onset MAA, wherein Cer and SM may serve as protective factors.
C1 [Wang, Shuqin; Wang, Sui] Anhui Med Univ, Dept Dermatol, Affiliated Hosp 1, 100 Huaihai Rd, Hefei 230022, Anhui, Peoples R China.
   [Wang, Shuqin; Wang, Sui] Anhui Publ Hlth Clin Ctr, Dept Dermatol, Hefei 230032, Anhui, Peoples R China.
   [Xu, Senmao] Anhui Med Univ, Dept Pediat, Affiliated Hosp 1, Hefei, Anhui, Peoples R China.
   [Fang, Wenhao] Anhui Med Univ, Dept Clin Lab, Affiliated Hosp 1, Hefei, Anhui, Peoples R China.
   [Shi, Wanrong] Anhui Med Univ, Hlth Management Ctr, Affiliated Hosp 1, Hefei, Anhui, Peoples R China.
C3 Anhui Medical University; Anhui Medical University; Anhui Medical
   University; Anhui Medical University
RP Wang, SQ (corresponding author), Anhui Med Univ, Dept Dermatol, Affiliated Hosp 1, 100 Huaihai Rd, Hefei 230022, Anhui, Peoples R China.
EM dwsq796@sina.com
RI Fang, Wenhao/C-3842-2015
OI Wang, Shuqin/0000-0002-0176-6599
FU Research fund of Anhui medical university [2022xkj202]
FX the research fund of Anhui medical university, Grant/Award Number:
   2022xkj202This study was funded by the research fund of Anhui medical
   university (No. 2022xkj202).
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NR 30
TC 4
Z9 4
U1 1
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1473-2130
EI 1473-2165
J9 J COSMET DERMATOL-US
JI J. Cosmet. Dermatol.
PD SEP
PY 2024
VL 23
IS 9
BP 3038
EP 3044
DI 10.1111/jocd.16371
EA MAY 2024
PG 7
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA E0J3P
UT WOS:001219742000001
PM 38738464
DA 2025-06-11
ER

EF﻿FN Clarivate Analytics Web of Science
VR 1.0
PT J
AU Lee, KY
   Zakaria, N
   Zakaria, N
AF Lee, Kun Yun
   Zakaria, Nursyahda
   Zakaria, Norhaniza
TI Examining the Impact of Burnout on Hospital Nurses Engaged in Shift
   Work: Insights From a Nationwide Cross-Sectional Study in Malaysia
SO SAGE OPEN NURSING
LA English
DT Article
DE burnout; depersonalization; emotional exhaustion; nursing staff;
   hospital
ID HEALTH-CARE; SLEEP QUALITY; SATISFACTION; PERFORMANCE; FATIGUE; BALANCE;
   STRESS; FAMILY
AB Introduction Shift workers follow nonstandard schedules that encompass overnight duty, rotational timetables, or permanent night work which can lead to misaligned core circadian physiology. Shift work has been associated with sleep deprivation, burnout, and metabolic syndrome among healthcare workers.Objective We aimed to examine if shift nurses working in Malaysian public hospitals are more predisposed to burnout and to determine the predictors of burnout in this profession.Method This national-level cross-sectional study was conducted among nurses in public hospitals in Malaysia between July and November 2019 using self-administered questionnaires. Maslach Burnout Inventory-Human Service Survey was used to determine burnout. Multistage stratified sampling was used to recruit nurses from 32 hospitals. A complex sampling analysis was performed.Results Among the 1,491 hospital nurses, more than half (70.8%) of them followed shift work schedules. Shift nurses were mostly below 40 years old (80.9%), diploma holders (87.2%), and of lower professional grades (64.2%). The prevalence of overall burnout, as well as the domains of emotional exhaustion and depersonalization, was higher among shift nurses (27.1%) as compared to their counterparts (22.4%). Nurses who performed more than six night shifts per month were 2.6 times more predisposed to burnout.Conclusion Shift work is integral to ensure round-the-clock nursing care for patients. However, nurses are increasingly faced with more shift duties due to heavy patient loads and staff shortages. Modified work schedules must be implemented to provide sufficient rest time for shift nurses to mitigate burnout. Additionally, proper human resource projection and distribution are imperative to prevent worsening burnout.
C1 [Lee, Kun Yun] Inst Hlth Management, Ctr Leadership & Profess Dev, Shah Alam, Malaysia.
   [Zakaria, Nursyahda] Inst Hlth Management, Shah Alam, Malaysia.
   [Zakaria, Norhaniza] Natl Inst Hlth, Minist Hlth Malaysia, Shah Alam, Malaysia.
   [Lee, Kun Yun] Inst Hlth Management, Blok B1,Kompleks NIH,Jln Setia Murni U13-52,Seksy, Shah Alam 40170, Malaysia.
C3 Kementerian Kesihatan Malaysia
RP Lee, KY (corresponding author), Inst Hlth Management, Blok B1,Kompleks NIH,Jln Setia Murni U13-52,Seksy, Shah Alam 40170, Malaysia.
EM dr.leekunyun@moh.gov.my
RI LEE, KY/MGW-1842-2025
OI LEE, KUN YUN/0000-0002-8606-3541
FU Ministry of Health (MOH) Research Grant
FX We wish to thank the Director General of Health, Malaysia for his
   permission to publish this article. Our gratitude to all the nurses who
   were involved in the study and the data collection team members.
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NR 54
TC 1
Z9 1
U1 8
U2 12
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 2377-9608
J9 SAGE OPEN NURS
JI SAGE Open Nurs.
PY 2024
VL 10
AR 23779608241245212
DI 10.1177/23779608241245212
PG 11
WC Nursing
WE Emerging Sources Citation Index (ESCI)
SC Nursing
GA MZ6Q0
UT WOS:001197499700001
PM 38585337
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Straat, ME
   Martinez-Tellez, B
   Janssen, LGM
   van Veen, S
   van Eenige, R
   Kharagjitsing, AV
   van den Berg, SAA
   de Rijke, YB
   Haks, MC
   Rensen, PCN
   Boon, MR
AF Straat, Maaike E.
   Martinez-Tellez, Borja
   Janssen, Laura G. M.
   van Veen, Suzanne
   van Eenige, Robin
   Kharagjitsing, Aan V.
   van den Berg, Sjoerd A. A.
   de Rijke, Yolanda B.
   Haks, Marielle C.
   Rensen, Patrick C. N.
   Boon, Mariette R.
TI The effect of cold exposure on circulating transcript levels of immune
   genes in Dutch South Asian and Dutch Europid men
SO JOURNAL OF THERMAL BIOLOGY
LA English
DT Article
DE Gene expression; Immune system; Cold stimulus; Ethnicity; Metabolic
   syndrome
ID INTERLEUKIN-1 RECEPTOR ANTAGONIST; NK CELLS; INSULIN-RESISTANCE; STRESS
   HORMONES; T-CELLS; OBESITY; SYSTEM; MOBILIZATION; MODULATION; ACTIVATION
AB Objectives: Although cold exposure is commonly believed to be causally related to acute viral respiratory infections, its effect on the immune system is largely unexplored. In this study, we determined transcript levels of a large panel of immune genes in blood before and after cold exposure. We included both Dutch Europid and Dutch South Asian men to address whether the immune system is differently regulated in the metabolically vulnerable South Asian population.
   Methods: Fasted blood samples were obtained from nonobese Dutch Europid (n = 11; mean age 26 +/- 3 y) and Dutch South Asian (n = 12; mean age 28 +/- 3 y) men before and directly after short-term (similar to 2.5 h) mild cold exposure. Transcript levels of 144 immune genes were measured using a dual-color reverse transcriptase multiplex ligation-dependent probe amplification (dcRT-MLPA) assay.
   Results: Cold exposure acutely upregulated mRNA levels of GNLY (+35%, P < 0.001) and PRF1 (+45%, P < 0.001), which encode cytotoxic proteins, and CCL4 (+8%, P < 0.01) and CCL5 (+5%, P < 0.05), both proinflammatory chemokines. At thermoneutrality, mRNA levels of four markers of the nucleotide-binding oligomerization domain (NOD)-like receptor (NLR)-family, involved in inflammasomes, were lower in Dutch South Asians compared to Dutch Europids, namely NLRP2 (-57%, P < 0.05), NLRP7 (-17%, P < 0.05), NLRP10 (-21%, P < 0.05), and NLRC4 (-23%, P < 0.05).
   Conclusions: Mild cold exposure acutely increases mRNA levels of genes involved in cytotoxicity of immune cells in blood. In addition, Dutch South Asians display lower circulating mRNA levels of inflammasome genes compared to Dutch Europids.
C1 [Straat, Maaike E.; Martinez-Tellez, Borja; Janssen, Laura G. M.; van Eenige, Robin; Kharagjitsing, Aan V.; Rensen, Patrick C. N.; Boon, Mariette R.] Leiden Univ, Med Ctr, Dept Med, Div Endocrinol, Leiden, Netherlands.
   [Straat, Maaike E.; Martinez-Tellez, Borja; Janssen, Laura G. M.; van Eenige, Robin; Rensen, Patrick C. N.; Boon, Mariette R.] Leiden Univ, Einthoven Lab Expt Vasc Med, Med Ctr, Leiden, Netherlands.
   [van Veen, Suzanne; Haks, Marielle C.] Leiden Univ, Dept Infect Dis, Med Ctr, Leiden, Netherlands.
   [Kharagjitsing, Aan V.] Vrije Univ Brussel, Dept Diabet & Endocrinol, Univ Hosp Brussels, Brussels, Belgium.
   [Kharagjitsing, Aan V.] Vrije Univ Brussel, Diabet Res Ctr, Brussels, Belgium.
   [van den Berg, Sjoerd A. A.; de Rijke, Yolanda B.] Erasmus MC, Univ Med Ctr Rotterdam, Dept Clin Chem, Rotterdam, Netherlands.
   [van den Berg, Sjoerd A. A.] Erasmus MC, Univ Med Ctr Rotterdam, Dept Internal Med, Rotterdam, Netherlands.
C3 Leiden University - Excl LUMC; Leiden University; Leiden University
   Medical Center (LUMC); Leiden University; Leiden University Medical
   Center (LUMC); Leiden University - Excl LUMC; Leiden University - Excl
   LUMC; Leiden University; Leiden University Medical Center (LUMC); Vrije
   Universiteit Brussel; University Hospital Brussels; Vrije Universiteit
   Brussel; Erasmus University Rotterdam; Erasmus MC; Erasmus University
   Rotterdam; Erasmus MC
RP Straat, ME (corresponding author), Albinusdreef 2, NL-2334 ZA Leiden, Netherlands.
EM M.E.Straat@lumc.nl
RI de Rijke, Yolanda/HLP-5779-2023; Tellez, Borja/R-5770-2019; Straat,
   Maaike/W-3802-2019; van den Berg, Sjoerd/R-9541-2018; Boon,
   Mariëtte/O-3660-2016; Haks, Marielle/G-1813-2014
OI van den Berg, Sjoerd/0000-0001-5937-7505; Haks,
   Marielle/0000-0002-7538-1800; Straat, Maaike/0000-0002-3148-8358; van
   Eenige, Robin/0000-0003-2637-3801; van Veen, Suzanne/0000-0003-1495-4334
FU AstraZeneca BV, a Dutch Diabetes Research Foundation Fellowship
   [2015.81.1808]; Netherlands Cardio-Vascular Research Initiative: 'the
   Dutch Heart Foundation; Dutch Federation of University Medical Centers;
   Netherlands Organisation for Health Research and Development; Royal
   Netherlands Academy of Sciences' [CVON2017-20 GENIUS-II]; Fundacion
   Alfonso Martin Escudero; Established Investigator of the Netherlands
   Heart Foundation [2009T038]
FX We thank Hetty Sips (Dept. Medicine, Div. Endocrinology, LUMC) for her
   excellent technical assistance. This work was conducted with support
   from AstraZeneca BV, a Dutch Diabetes Research Foundation Fellowship to
   MB (grant 2015.81.1808) and the Netherlands Cardio-Vascular Research
   Initiative: 'the Dutch Heart Foundation, Dutch Federation of University
   Medical Centers, the Netherlands Organisation for Health Research and
   Development and the Royal Netherlands Academy of Sciences' (CVON2017-20
   GENIUS-II) to PR. BM is supported by individual postdoctoral grant from
   the Fundacion Alfonso Martin Escudero. PR is an Established Investigator
   of the Netherlands Heart Foundation (grant 2009T038).
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NR 74
TC 4
Z9 5
U1 1
U2 6
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4565
EI 1879-0992
J9 J THERM BIOL
JI J. Therm. Biol.
PD JUL
PY 2022
VL 107
AR 103259
DI 10.1016/j.jtherbio.2022.103259
PG 9
WC Biology; Zoology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics; Zoology
GA DE7P3
UT WOS:001130422100006
PM 35701026
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Xu, L
   Zou, XY
   Gao, ZQ
   Mao, CF
   Su, H
   Li, CY
   Chen, N
AF Xu, Lei
   Zou, Xiaoyu
   Gao, Zhiqiang
   Mao, Caifeng
   Su, Hang
   Li, Chunyan
   Chen, Ning
TI Improved fatty acid profile reduces body fat and arterial stiffness in
   obese adolescents upon combinatorial intervention with exercise and
   dietary restriction
SO JOURNAL OF EXERCISE SCIENCE & FITNESS
LA English
DT Article
DE Obese adolescents; Exercise intervention; Dietary restriction; Serum
   fatty acid; Arterial stiffness; Weight loss
ID LIFE-STYLE INTERVENTION; GAMMA-LINOLENIC ACID; WEIGHT-LOSS;
   CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; SERUM; OVERWEIGHT; RISK;
   ASSOCIATION; STRESS
AB Objective: In order to examine the effect of 4-week combinatorial intervention with exercise training and dietary restriction on serum fatty acids, and to explore the correlation of intervention-induced improvement of serum fatty acid profile with the reduction of body fat and arterial stiffness.
   Methods: Thirty-three obese adolescents were randomized into the intervention (n = 19) and control (n = 14) groups. The participants from the intervention group were subjected to 4-week combinatorial intervention with exercise training and dietary restriction while the participants from the control group maintained regular activities and diet habits. Anthropometry, serum fatty acids and arterial stiffness were measured before and after 4-week intervention.
   Results: The participants upon combinatorial intervention revealed the improved body compositions and serum fatty acid profile, and reduced arterial stiffness when compared with their basal levels and the control participants (p < 0.05). Moreover, the decrease in myristic acid, stearic acid, arachidic acid, behenic acid, palmitoleic acid, and dihomo-g-linolenic acid, was associated with the reduction in body fat. A positive correlation between arachidonic acid and left brachial ankle pulse velocity was observed, and the increase in docosahexaenoic acid was associated with the reduction of left brachial ankle pulse wave velocity and the enhancement of right ankle brachial index.
   Conclusion: The 4-week combinatorial intervention is a useful strategy to improve serum fatty acid profile along with the reduction of body fat and arterial stiffness in obese adolescents. (C) 2021 The Society of Chinese Scholars on Exercise Physiology and Fitness. Published by Elsevier (Singapore) Pte Ltd.
C1 [Xu, Lei; Zou, Xiaoyu; Gao, Zhiqiang; Mao, Caifeng; Su, Hang] Wuhan Sports Univ, Grad Sch, Wuhan 430079, Peoples R China.
   [Li, Chunyan; Chen, Ning] Wuhan Sports Univ, Coll Hlth Sci, Hubei Key Lab Exercise Training & Monitoring, Tianjiu Res & Dev Ctr Exercise Nutr & Foods, Wuhan 430079, Peoples R China.
C3 Wuhan Sports University; Wuhan Sports University
RP Li, CY; Chen, N (corresponding author), Wuhan Sports Univ, Coll Hlth Sci, Hubei Key Lab Exercise Training & Monitoring, Wuhan 430079, Peoples R China.
EM lichunyan22@126.com; nchen510@gmail.com
RI Chen, Ning/AAM-9513-2021; Li, Chunyan/F-5309-2016; Xu, Lei/HTP-4994-2023
OI Chen, Ning/0000-0002-8191-6744; Xu, Lei/0000-0002-1742-4657
FU Scientific Research Program from Hubei Provincial Department of
   Education [B2017232]; Key Special Project of Disciplinary Development,
   Hubei Superior Discipline Groups of Physical Education and Health
   Promotion; Outstanding Youth Scientific and Technological Innovation
   Team from Hubei Provincial Department of Education [T201624]; Chutian
   Scholar Program and Innovative Start-up Foundation from Wuhan Sports
   University
FX We would like to thank all participants for their involvement in this
   study. This study was financially supported by the Scientific Research
   Program from Hubei Provincial Department of Education (B2017232) to CL,
   and the Key Special Project of Disciplinary Development, Hubei Superior
   Discipline Groups of Physical Education and Health Promotion, the
   Outstanding Youth Scientific and Technological Innovation Team (T201624)
   from Hubei Provincial Department of Education, and Chutian Scholar
   Program and Innovative Start-up Foundation from Wuhan Sports University
   to NC.
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NR 49
TC 5
Z9 6
U1 2
U2 10
PU ELSEVIER SINGAPORE PTE LTD
PI SINGAPORE
PA 3 KILLINEY ROAD 08-01, WINSLAND HOUSE 1, SINGAPORE, 239519, SINGAPORE
SN 1728-869X
J9 J EXERC SCI FIT
JI J. Exerc. Sci. Fit.
PD OCT
PY 2021
VL 19
IS 4
BP 234
EP 240
DI 10.1016/j.jesf.2021.08.003
EA SEP 2021
PG 7
WC Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Sport Sciences
GA UZ1MD
UT WOS:000701975000005
PM 34552635
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Cao, CC
   Duan, P
   Li, WC
   Guo, Y
   Zhang, J
   Gui, YT
   Yuan, SQ
AF Cao, Congcong
   Duan, Peng
   Li, Wencun
   Guo, Yang
   Zhang, Jin
   Gui, Yaoting
   Yuan, Shuiqiao
TI Lack of miR-379/miR-544 Cluster Resists High-Fat Diet-Induced
   Obesity and Prevents Hepatic Triglyceride Accumulation in Mice
SO FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
LA English
DT Article
DE miR-379; miR-544; obesity; liver; mouse; knockout; high-fat diet
ID INSULIN-RESISTANCE; IGF-I; LIVER; DLK1; EXPRESSION; RECEPTORS; GENES;
   ADIPOGENESIS; INACTIVATION; INHIBITION
AB Non-alcoholic fatty liver disease (NAFLD) affects obesity-associated metabolic syndrome, which exhibits hepatic steatosis, insulin insensitivity and glucose intolerance. Emerging evidence suggests that microRNAs (miRNAs) are essential for the metabolic homeostasis of liver tissues. Many hepatic miRNAs located in the miR-379/miR-544 cluster were significantly increased in leptin-receptor-deficient type 2 mice (db/db), a mouse model of diabetes. However, the function of the miR-379/miR-544 cluster in the process of hepatic steatosis remains unclear. Here, we report that the novel function of miR-379/miR-544 cluster in regulating obesity-mediated metabolic dysfunction. Genetical mutation of miR-379/miR-544 cluster in mice displayed resistance to high-fat diet (HFD)-induced obesity with moderate hepatic steatosis and hypertriglyceridemia. In vitro studies revealed that silencing of miR-379 in human hepatocellular carcinoma (HepG2) cells ameliorated palmitic acid-induced elevation of cellular triglycerides, and overexpression of miR-379 had the opposite effect. Moreover, Igf1r (Insulin-like growth factor 1 receptor) and Dlk1 (Delta-like homolog 1) were directly targeted by miR-379 and miR-329, respectively, and elevated in the livers of the miR-379/miR-544 cluster knockout mice fed on HFD. Further transcriptome analyses revealed that the hepatic gene expressions are dysregulated in miR-379/miR-544 knockout mice fed with HFD. Collectively, our findings identify the miR-379/miR-544 cluster as integral components of a regulatory circuit that functions under conditions of metabolic stress to control hepatic steatosis. Thus, this miRNA cluster provides potential targets for pharmacologic intervention in obesity and NAFLD.</p>
C1 [Cao, Congcong; Zhang, Jin; Yuan, Shuiqiao] Huazhong Univ Sci & Technol, Inst Reprod Hlth, Tongji Med Coll, Wuhan, Hubei, Peoples R China.
   [Cao, Congcong; Gui, Yaoting] Hong Kong Univ Sci & Technol, Shenzhen Peking Univ, Peking Univ,Inst Urol,Shenzhen Hosp,Med Ctr, Guangdong & Shenzhen Key Lab Male Reprod Med & Ge, Shenzhen, Guangdong, Peoples R China.
   [Duan, Peng] Hubei Univ Med, Xiangyang Peoples Hosp 1, Dept Obstet & Gynaecol, Xiangyang, Peoples R China.
   [Li, Wencun] Zhejiang Univ, Coll Med, Affiliated Hosp 2, Hangzhou, Zhejiang, Peoples R China.
   [Guo, Yang] Hubei Univ Med, Coll Pharm, Shiyan, Peoples R China.
   [Yuan, Shuiqiao] Shenzhen Huazhong Univ Sci & Technol, Res Inst, Shenzhen, Guangdong, Peoples R China.
C3 Huazhong University of Science & Technology; Peking University; Hong
   Kong University of Science & Technology; Hubei University of Medicine;
   Zhejiang University; Hubei University of Medicine; Huazhong University
   of Science & Technology; Shenzhen Huazhong University of Science &
   Technology Research Institute
RP Yuan, SQ (corresponding author), Huazhong Univ Sci & Technol, Inst Reprod Hlth, Tongji Med Coll, Wuhan, Hubei, Peoples R China.; Yuan, SQ (corresponding author), Shenzhen Huazhong Univ Sci & Technol, Res Inst, Shenzhen, Guangdong, Peoples R China.
EM shuiqiaoyuan@hust.edu.cn
RI Yuan, Shuiqiao/AAX-1467-2021; gui, yaoting/GLT-3684-2022; Cao,
   Congcong/L-3312-2018; Yuan, Shuiqiao/O-2755-2014
OI Yuan, Shuiqiao/0000-0003-1460-7682
FU Science Technology and Innovation Commission of Shenzhen Municipality
   [JCYJ20170244]; Natural Science Foundation of Hubei Provincial
   Department of Education [Q20202105]
FX This work was supported by grants from the Science Technology and
   Innovation Commission of Shenzhen Municipality (JCYJ20170244 to SY) and
   the Natural Science Foundation of Hubei Provincial Department of
   Education (Q20202105 to PD).
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NR 46
TC 10
Z9 10
U1 1
U2 11
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-634X
J9 FRONT CELL DEV BIOL
JI Front. Cell. Dev. Biol.
PD AUG 30
PY 2021
VL 9
AR 720900
DI 10.3389/fcell.2021.720900
PG 14
WC Cell Biology; Developmental Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Developmental Biology
GA UT0SV
UT WOS:000697836300001
PM 34527673
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Santa Cruz, EC
   Zandonadi, FD
   Fontes, W
   Sussulini, A
AF Santa Cruz, Elisa Castaneda
   Zandonadi, Flavia da Silva
   Fontes, Wagner
   Sussulini, Alessandra
TI A pilot study indicating the dysregulation of the complement and
   coagulation cascades in treated schizophrenia and bipolar disorder
   patients
SO BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
LA English
DT Article
DE Bipolar disorder; Schizophrenia; Bioinformatics; Antipsychotic side
   effects; Proteomics
ID THROMBIN-ACTIVATABLE FIBRINOLYSIS; MAJOR DEPRESSIVE DISORDER;
   CORONARY-HEART-DISEASE; BINDING-PROTEIN 4; METABOLIC SYNDROME; OXIDATIVE
   STRESS; NETWORK ANALYSIS; SERUM; PLASMA; PROTEOMICS
AB A better understanding of the proteome profile after bipolar disorder (BD) and schizophrenia (SCZ) treatment, besides monitoring disease progression, may assist on the development of novel therapeutic strategies with the ability to reduce or control possible side effects. In this pilot study, proteomics analysis employing nano liquid chromatography coupled to mass spectrometry (nLC-MS) and bioinformatic tools were applied to identify differentially abundant proteins in serum of treated BD and SCZ patients. In total, 10 BD patients, 10 SCZ patients, and 14 healthy controls (HC) were included in this study. 24 serum proteins were significantly altered (p < 0.05) in BD and SCZ treated patients and, considering log(2)FC > 0.58, 8 proteins presented lower abundance in the BD group, while 7 proteins presented higher abundance and 2 lower abundance in SCZ group when compared against HC. Bioinformatics analysis based on these 24 proteins indicated two main altered pathways previously described in the literature; furthermore, it revealed that opposite abundances of the complement and coagulation cascades were the most significant biological processes involved in these pathologies. Moreover, we describe disease-related proteins and pathways associations suggesting the necessity of clinical follow-up improvement besides treatment, as a precaution or safety measure, along with the disease progression. Further biological validation and investigations are required to define whether there is a correlation between complement and coagulation cascade expression for BD and SCZ and cardiovascular diseases.
C1 [Santa Cruz, Elisa Castaneda; Zandonadi, Flavia da Silva; Sussulini, Alessandra] Univ Campinas UNICAMP, Inst Chem, Dept Analyt Chem, Lab Bioanalyt & Integrated Omics LaBIOmics, BR-13083970 Campinas, SP, Brazil.
   [Fontes, Wagner] Univ Brasilia UnB, Inst Biol, Dept Cell Biol, Lab Prot Chem & Biochem, BR-70910900 Brasilia, DF, Brazil.
   [Sussulini, Alessandra] Univ Campinas UNICAMP, Natl Inst Sci & Technol Bioanalyt INCTBio, Inst Chem, BR-13083970 Campinas, SP, Brazil.
C3 Universidade Estadual de Campinas; Universidade de Brasilia;
   Universidade Estadual de Campinas
RP Sussulini, A (corresponding author), Univ Campinas UNICAMP, Inst Chem, Dept Analyt Chem, Lab Bioanalyt & Integrated Omics LaBIOmics, BR-13083970 Campinas, SP, Brazil.
EM sussulini@unicamp.br
RI Sussulini, Alessandra/B-1700-2009; Santa Cruz, Elisa/ABB-1430-2020;
   Zandonadi, Flavia/JZC-8981-2024; Fontes, Wagner/A-1771-2008
OI Fontes, Wagner/0000-0001-5140-8573; Castaneda Santa Cruz,
   Elisa/0000-0002-1044-6191
FU Sao Paulo Research Foundation (FAPESP) [2018/01525-3]; National Council
   for Scientific and Technological Development (CNPq) [141439/2016-5];
   INCT of Bioanalytics [FAPESP 2014/50867-3, CNPq 465389/2014-7]; Fundacao
   de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [18/01525-3,
   14/50867-3] Funding Source: FAPESP
FX This project has received funding from the Sao Paulo Research Foundation
   (FAPESP, grant number 2018/01525-3), National Council for Scientific and
   Technological Development (CNPq, grant number 141439/2016-5), and INCT
   of Bioanalytics (FAPESP 2014/50867-3 and CNPq 465389/2014-7 grant
   numbers).
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NR 95
TC 13
Z9 13
U1 1
U2 8
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1570-9639
EI 1878-1454
J9 BBA-PROTEINS PROTEOM
JI BBA-Proteins Proteomics
PD AUG
PY 2021
VL 1869
IS 8
AR 140657
DI 10.1016/j.bbapap.2021.140657
EA APR 2021
PG 11
WC Biochemistry & Molecular Biology; Biophysics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Biochemistry & Molecular Biology; Biophysics
GA SK3RM
UT WOS:000656136200008
PM 33839315
DA 2025-06-11
ER

PT J
AU Ma, ZM
   Xu, CN
   Kang, XP
   Zhang, S
   Li, HB
   Tao, LX
   Zheng, DQ
   Guo, XH
   Yang, XH
AF Ma, Zhimin
   Xu, Chaonan
   Kang, Xiaoping
   Zhang, Shan
   Li, Haibin
   Tao, Lixin
   Zheng, Deqiang
   Guo, Xiuhua
   Yang, Xinghua
TI Changing trajectories of serum uric acid and risk of non-alcoholic fatty
   liver disease: a prospective cohort study
SO JOURNAL OF TRANSLATIONAL MEDICINE
LA English
DT Article
DE Non-alcoholic fatty liver disease; Serum uric acid; Changing trajectory;
   Dose-response relationship
ID METABOLIC SYNDROME; ALANINE AMINOTRANSFERASE; INSULIN-RESISTANCE;
   OXIDATIVE STRESS; POPULATION; ASSOCIATION; HYPERURICEMIA; METAANALYSIS;
   PREVALENCE; EPIDEMIOLOGY
AB Background It is unclear the role of longitudinal trajectory of serum uric acid (SUA) on the development of non-alcoholic fatty liver disease (NAFLD). We aimed to determine whether longitudinal SUA trajectories are associated with the risk of new-onset NAFLD. Methods We explored the relationship between SUA trajectories and NAFLD in a cohort including 3822 participants. Individual's SUA trajectories from 2012 to 2014 were defined using group-based trajectory modeling analysis in four distinct patterns: trajectory 1 (n = 991, 25.93%), trajectory 2 (n = 1421, 37.18%), trajectory 3 (n = 1156, 30.22%), and trajectory 4 (n = 254, 6.67%). The logistic regression model was used to evaluate the association between SUA changing trajectories and subsequent NAFLD until 2016. Dose-response relationship between SUA changing trajectories and NAFLD risk was evaluated through the testing of trajectory groups as a continuous variable. Results The 2-year incidence of NAFLD was 13.27%. Compared with trajectory 1, the adjusted odds risk for NAFLD development was in a dose-response relationship as follows: 1.27 (95% CI 0.91-1.78) for trajectory 2, 1.89 (95% CI 1.29-2.75) for trajectory 3, and 2.34 (95% CI 1.43-3.83) for trajectory 4. And this dose-response relationship was not affected by age, sex, and abdominal obesity. Conclusions Higher SUA changing trajectory is a risk factor for NAFLD. This finding highlights the importance of paying attention to SUA changing trajectory on the detection and prevention of NAFLD.
C1 [Ma, Zhimin; Xu, Chaonan; Zhang, Shan; Li, Haibin; Tao, Lixin; Zheng, Deqiang; Guo, Xiuhua; Yang, Xinghua] Capital Med Univ, Sch Publ Hlth, 10 Xitoutiao, Beijing 100069, Peoples R China.
   [Ma, Zhimin; Zhang, Shan; Li, Haibin; Tao, Lixin; Zheng, Deqiang; Guo, Xiuhua; Yang, Xinghua] Beijing Municipal Key Lab Clin Epidmiol, 10 Xitoutiao, Beijing 100069, Peoples R China.
   [Xu, Chaonan] Peking Univ, Med Engn Dept, Hosp 3, 49 HuaYuan BeiLu, Beijing 100191, Peoples R China.
   [Kang, Xiaoping] Beijing Xiaotangshan Hosp, 390 Wenquan St, Beijing 102211, Peoples R China.
C3 Capital Medical University; Peking University
RP Yang, XH (corresponding author), Capital Med Univ, Sch Publ Hlth, 10 Xitoutiao, Beijing 100069, Peoples R China.
EM xinghuayang@ccmu.edu.cn
RI TAO, Li/HIR-4254-2022; Li, Hai-Bin/H-1407-2011
OI Li, Haibin/0000-0002-6932-982X; Ma, Zhimin/0000-0002-1354-1055
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NR 45
TC 30
Z9 36
U1 1
U2 17
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1479-5876
J9 J TRANSL MED
JI J. Transl. Med.
PD MAR 19
PY 2020
VL 18
IS 1
AR 133
DI 10.1186/s12967-020-02296-x
PG 8
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA KX7UT
UT WOS:000522082900001
PM 32192511
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Hidalgo, I
   Nájera, N
   Meaney, E
   Pérez-Durán, J
   Valdespino-Vazquez, Y
   Villarreal, F
   Ceballos, G
AF Hidalgo, Isabel
   Najera, Nayelli
   Meaney, Eduardo
   Perez-Duran, Javier
   Valdespino-Vazquez, Yolotzin
   Villarreal, Francisco
   Ceballos, Guillermo
TI Effects of (-)-epicatechin on the time course of the expression of
   perilipins in a diet-induced model of nonalcoholic steatohepatitis
SO JOURNAL OF NUTRITIONAL BIOCHEMISTRY
LA English
DT Article
ID FATTY-LIVER-DISEASE; INSULIN-RESISTANCE; METABOLIC SYNDROME; HEPATIC
   STEATOSIS; GREEN TEA; LIPID-ACCUMULATION; OXIDATIVE STRESS; PROTEIN;
   ADIPONECTIN; OBESITY
AB The existing treatments for nonalcoholic steatohepatitis (NASH) are not completely effective. The need for new alternatives without adverse effects and low cost, such as the flavonoid (-)-epicatechin (EC), which has beneficial effects on lipid metabolism and cardiovascular diseases, arises. The objective of this work was to analyze EC effects in the NASH induced by a Paigen-type diet (PD). Mice were administered with (1) normal chow and water, (2) PD + fructose 30% and (3) PD + fructose 30% + EC (1 mg/kg) per gavage during 9 weeks. At the end of each treatment, serum was collected for analysis of the biochemical profile and liver enzymes, The liver was collected for microscopic analysis and for the evaluation of the relative expression of Plin2, Plin3, CD36, adiponectin and UCP2. Results showed that EC reduced weight gain and decreased triglyceride (TG), low-density lipoprotein cholesterol, TG/high-density lipoprotein and the activity of liver enzymes (alanine aminotransferase and alkaline phosphatase), suggesting lower liver damage. The microscopic analysis showed less "balloonization" of the hepatocyte, small drops of lipids, less accumulation of collagen and infiltration of inflammatory cells as compared to nontreated group. Finally, a decrease in the expression of Plin 2 was observed. While CD36 decreased, adiponectin and UCP2 increased. In conclusion, EC improves the biochemical profile, the microscopic characteristics and protein expression. Therefore, it may be a possible therapeutic approach for NASH since it prevents the progression of the hepatic and metabolic damage induced by high-fat diets. (C) 2019 Elsevier Inc. All rights reserved.
C1 [Hidalgo, Isabel; Najera, Nayelli; Meaney, Eduardo; Ceballos, Guillermo] Inst Politecn Nacl, Escuela Super Med, Secc Posgrad, Salvador Diaz Miron Esq Plan San Luis S-N, Mexico City 11390, DF, Mexico.
   [Perez-Duran, Javier] Inst Nacl Perinatol, Lab Genet & Genom Humana, Montes Urales 800, Mexico City 11000, DF, Mexico.
   [Valdespino-Vazquez, Yolotzin] Inst Nacl Perinatol, Anat Patol, Montes Urales 800, Mexico City 11000, DF, Mexico.
   [Villarreal, Francisco] Univ Calif San Diego, Sch Med, Dept Med, La Jolla, CA 92093 USA.
C3 Instituto Politecnico Nacional - Mexico; Universidad Nacional Autonoma
   de Mexico; Universidad Nacional Autonoma de Mexico; University of
   California System; University of California San Diego
RP Ceballos, G (corresponding author), Inst Politecn Nacl, Secc Posgrad, Salvador Diaz Miron Esq Plan San Luis S-N, Mexico City 11340, DF, Mexico.
EM gceballosr@ipn.mx
RI Ceballos, Guillermo/A-7507-2013; Najera, Nayelli/P-3146-2016
OI VALDESPINO VAZQUEZ, MARIA YOLOTZIN/0000-0003-4735-4730; Ceballos,
   Guillermo/0000-0003-2155-3934; Hidalgo, Emma Isabel/0000-0003-0276-9414;
   Perez Duran, Javier/0000-0003-3302-7720; Najera,
   Nayelli/0000-0002-6869-8762
FU project CONACYT (National Council of Science and Technology) [253769,
   SIP 20195094]
FX this work was supported by project CONACYT (National Council of Science
   and Technology, grant 253769) and Project SIP 20195094.
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NR 66
TC 11
Z9 12
U1 1
U2 22
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0955-2863
EI 1873-4847
J9 J NUTR BIOCHEM
JI J. Nutr. Biochem.
PD MAR
PY 2020
VL 77
AR 108296
DI 10.1016/j.jnutbio.2019.108296
PG 10
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA KQ4GN
UT WOS:000516883200003
PM 32007822
DA 2025-06-11
ER

PT J
AU Zhao, W
   Zhang, L
   Zhang, GL
   Varkaneh, HK
   Rahmani, J
   Clark, C
   Ryan, PM
   Abdulazeem, HM
   Salehisahlabadi, A
AF Zhao, Wei
   Zhang, Li
   Zhang, Guoliang
   Varkaneh, Hamed Kord
   Rahmani, Jamal
   Clark, Cain
   Ryan, Paul M.
   Abdulazeem, Hebatullah M.
   Salehisahlabadi, Ammar
TI The association of plasma levels of liver enzymes and risk of
   gestational diabetes mellitus: a systematic review and dose-response
   meta-analysis of observational studies
SO ACTA DIABETOLOGICA
LA English
DT Review
DE Gestational diabetes mellitus; Gamma-glutamyl transferase; Liver enzymes
ID GAMMA-GLUTAMYL-TRANSFERASE; SERUM ALANINE AMINOTRANSFERASE;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; OXIDATIVE STRESS; MID-PREGNANCY;
   FOLLOW-UP; TRANSPEPTIDASE; COMPLICATIONS; PREVALENCE
AB Aims Relationship between liver enzymes such as gamma-glutamyl transferase (GGT), alanine aminotransferase (ALT), aspartate transaminase (AST) and alkaline phosphatase and risk of gestational diabetes mellitus (GDM) is a controversial issue. The aim of this systematic review and dose-response meta-analysis was to investigate the association between liver enzymes and risk of GDM in observational studies. Methods A comprehensive systematic literature search was conducted in MEDLINE/PubMed, SCOPUS and Web of Science databases up to September 2019. Combined odds ratios (ORs) with 95% confidence intervals (CIs) were evaluated by DerSimonian and Laird random-effects models. Dose-response analyses of these relationships were also carried out. Results Eight studies with 25,451 participants containing 2549 cases were included in this study. Pooled results showed a significant association between GGT levels and risk of GDM (OR 2.10, 95% CI 1.14-3.86, I-2 84%). In addition, random-effects model indicated a dramatic and direct significant association between GGT and risk of GDM in nonlinear (p < 0.001) and linear (p < 0.001) dose-response analysis. Associations between ALT and AST with risk of GDM were found to be non-significant (OR 1.32, 95% CI 0.91-1.90, I-2 65% and OR 0.76, 95% CI 0.52-1.10, I-2 16%, respectively). Conclusion This systematic review and dose-response meta-analysis highlights GGT as a significant and robust predictor of the incidence of GDM in pregnant women.
C1 [Zhao, Wei; Zhang, Li; Zhang, Guoliang] Inner Mongolia Univ Nationalities, Dept Obstet & Gynecol, Affiliated Hosp, Tongliao 028000, Neimenggu, Peoples R China.
   [Varkaneh, Hamed Kord; Salehisahlabadi, Ammar] Shahid Beheshti Univ Med Sci, Natl Nutr & Food Technol Res Inst, Fac Nutr & Food Technol, Dept Clin Nutr & Dietet, Tehran, Iran.
   [Rahmani, Jamal] Shahid Beheshti Univ Med Sci, Natl Nutr & Food Technol Res Inst, Fac Nutr & Food Technol, Dept Community Nutr,Student Res Comm, Tehran, Iran.
   [Clark, Cain] Coventry Univ, Ctr Sport Exercise & Life Sci, Coventry CV1 5FB, W Midlands, England.
   [Ryan, Paul M.] Univ Coll Cork, Sch Med, Cork, Ireland.
   [Abdulazeem, Hebatullah M.] AICPD, Arab Diploma Family Med, Cairo, Egypt.
C3 Inner Mongolia Minzu University; Shahid Beheshti University Medical
   Sciences; Shahid Beheshti University Medical Sciences; Coventry
   University; University College Cork
RP Zhao, W (corresponding author), Inner Mongolia Univ Nationalities, Dept Obstet & Gynecol, Affiliated Hosp, Tongliao 028000, Neimenggu, Peoples R China.
EM zhaoweia4@sina.com
RI Abdulazeem, Hebatullah/AAF-8131-2020; salehi-sahlabadi,
   ammar/KHD-7718-2024; Clark, Cain/I-4480-2019; Ryan, Paul/ABG-5352-2020
OI Ryan, Paul MacDaragh/0000-0001-7251-6725; Abdulazeem,
   Hebatullah/0000-0002-4529-7114; Clark, Dr. Cain/0000-0002-6610-4617
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NR 56
TC 15
Z9 16
U1 2
U2 16
PU SPRINGER-VERLAG ITALIA SRL
PI MILAN
PA VIA DECEMBRIO, 28, MILAN, 20137, ITALY
SN 0940-5429
EI 1432-5233
J9 ACTA DIABETOL
JI Acta Diabetol.
PD JUN
PY 2020
VL 57
IS 6
BP 635
EP 644
DI 10.1007/s00592-019-01458-8
EA NOV 2019
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA LN1TP
UT WOS:000499232400001
PM 31781958
DA 2025-06-11
ER

PT J
AU Son, M
   Wu, JP
AF Son, Myoungjin
   Wu, Jianping
TI Egg white hydrolysate and peptide reverse insulin resistance associated
   with tumor necrosis factor-α (TNF-α) stimulated mitogen-activated
   protein kinase (MAPK) pathway in skeletal muscle cells
SO EUROPEAN JOURNAL OF NUTRITION
LA English
DT Article
DE Insulin resistance; Skeletal muscle cells; Egg white protein
   hydrolysate; IRW; Insulin signaling
ID GLUCOSE-UPTAKE; INFLAMMATORY RESPONSE; METABOLIC-SYNDROME;
   BLOOD-PRESSURE; EXPRESSION; OBESITY; IRW; HYPERGLYCEMIA; INHIBITION;
   STRESS
AB Purpose Excessive formation of tumor necrosis factor-alpha(TNF-alpha), a pro-inflammatory cytokine, has been implicated in the development of insulin resistance in obesity and type-2 diabetes. In skeletal muscle, chronic exposure to TNF-alpha impairs insulin-stimulated glucose uptake and insulin signaling. The aim of this study is to investigate the effects of enzymatic egg white hydrolysate (EWH) and its responsible peptide, IRW, on TNF-alpha-induced insulin resistance and the underlying molecular mechanisms using rat skeletal muscle cells (L6 cells).
   Methods Insulin resistance was induced by treating L6 cells with 5ng/ml TNF-alpha for 24h. Effects of EWH and IRW on glucose uptake were detected by glucose uptake assay, glucose transporter 4 (GLUT4) translocation by immunofluorescence, and western blot, while insulin-signaling pathway and mitogen-activated protein kinase (MAPK) pathway were investigated using western blot.
   Results Adding both EWH and IRW significantly improved glucose uptake in TNF-alpha-treated cells, increased activation of insulin receptor substrate (IRS-1) tyrosine residue and protein kinase B (Akt), whereas decreased activation of IRS-1 serine residue. In addition, TNF-alpha-induced activation of p38-mitogen-activated protein kinase (p38) and c-Jun N-terminal kinases (JNK) 1/2 were decreased by either EWH or IRW treatment.
   Conclusion EWH and IRW improve impaired insulin sensitivity by down-regulating the activation of p38 and JNK1/2 in TNF-alpha-treated skeletal muscle cells.
C1 [Son, Myoungjin; Wu, Jianping] Univ Alberta, Dept Agr Food & Nutr Sci, Edmonton, AB T6G 2P5, Canada.
   [Wu, Jianping] Univ Alberta, Cardiovasc Res Ctr, Edmonton, AB T6G 2P5, Canada.
C3 University of Alberta; University of Alberta
RP Wu, JP (corresponding author), Univ Alberta, Dept Agr Food & Nutr Sci, Edmonton, AB T6G 2P5, Canada.; Wu, JP (corresponding author), Univ Alberta, Cardiovasc Res Ctr, Edmonton, AB T6G 2P5, Canada.
EM jwu3@ualberta.ca
RI Wu, Jianping/H-9150-2012
FU Alberta Livestock and Meat Agency, (ALMA); Natural Sciences and
   Engineering Research Council of Canada (NSERC); Egg Farmers of Canada
FX This work is supported by research grants from the Alberta Livestock and
   Meat Agency, (ALMA), Egg Farmers of Canada, and the Natural Sciences and
   Engineering Research Council of Canada (NSERC).
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NR 46
TC 36
Z9 41
U1 2
U2 32
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1436-6207
EI 1436-6215
J9 EUR J NUTR
JI Eur. J. Nutr.
PD AUG
PY 2019
VL 58
IS 5
BP 1961
EP 1969
DI 10.1007/s00394-018-1753-7
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA IK3MJ
UT WOS:000476492800018
PM 29955954
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Zhang, L
   Li, HX
   Pan, WS
   Khan, FU
   Qian, C
   Qi-Li, FR
   Xu, XJ
AF Zhang, Li
   Li, Hui-Xia
   Pan, Wu-Si
   Khan, Farhan Ullah
   Qian, Cheng
   Qi-Li, Feng-Rong
   Xu, Xiaojun
TI Novel hepatoprotective role of Leonurine hydrochloride against
   experimental non-alcoholic steatohepatitis mediated via
   AMPK/SREBP1 signaling pathway
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Article
DE Non-alcoholic steatohepatitis; Steatosis; Inflammation; Fibrosis;
   Leonurine; AMPK
ID FATTY-LIVER-DISEASE; ACTIVATED PROTEIN-KINASE; OXIDATIVE STRESS;
   GENE-EXPRESSION; MECHANISMS; AMPK; FIBROSIS; ATHEROSCLEROSIS;
   INFLAMMATION; PROGRESSION
AB Background and aims: Non-alcoholic steatohepatitis (NASH) is the hepatic manifestation of metabolic syndrome and is characterized by steatosis, inflammation, and fibrosis. We aim to characterize the hepatoprotective effects of Leonurine hydrochloride (LH) and the possible pathway in a cell and rodent model of diet-induced steatohepatitis (NASH).
   Methods: For in vitro studies, Palmitic acid (PA) and free fatty acid (FFA) induced HepG2 and HL7702 steatosis cell models were used. For in vivo studies, NASH was induced by feeding mice MCD diet These mice received either placebo or LH at three different doses (50, 100, 200 mg/kg/day) for 6 weeks. Histological staining's, and commercially available kits for ALT and AST and hepatic contents of TG, TC, MDA, SOD, and GSH were used to assess NASH. Furthermore, relative liver protein and gene expression levels were determined by Western Blot and qPCR, respectively.
   Results: After establishing NASH models, LH treatment improved lipid accumulation, hepatic contents of TG, TC, and expression levels of ALT and AST in dose-dependent manner. Also, LH improved MDA, SOD, and GSH expression levels. The results of RT-PCR and Western blotting showed that LH upregulated the expression of AMPK phosphorylation and downregulated SREBP-1 c and its target genes expression level.
   Conclusions: Our data reveal the promising role of Leonurine hydrochloride in the prevention and treatment of NASH, in vitro and in vivo. This effect may be partially mediated by the AMPK/SREBP1 pathway. These findings provide a novel therapeutic target for the clinical treatment of NASH.
C1 [Zhang, Li; Li, Hui-Xia; Pan, Wu-Si; Qi-Li, Feng-Rong; Xu, Xiaojun] China Pharmaceut Univ, State Key Lab Nat Med, Nanjing 210009, Jiangsu, Peoples R China.
   [Khan, Farhan Ullah] Shanghai Jiao Tong Univ, Sch Pharm, 800 Dongchuan Rd, Shanghai 200240, Peoples R China.
   [Qian, Cheng] Nanjing Med Univ, Sir Run Run Hosp, Dept Nephrol, Nanjing 211166, Jiangsu, Peoples R China.
   [Xu, Xiaojun] China Pharmaceut Univ, Jiangsu Key Lab Drug Discovery Metab Dis, Nanjing 210009, Jiangsu, Peoples R China.
C3 China Pharmaceutical University; Shanghai Jiao Tong University; Nanjing
   Medical University; China Pharmaceutical University
RP Xu, XJ (corresponding author), China Pharmaceut Univ, State Key Lab Nat Med, Nanjing 210009, Jiangsu, Peoples R China.
EM xiaojunxu@cpu.edu.cn
RI Khan, Farhan Ullah/CAJ-4327-2022; Qian, Cheng/ACI-6931-2022
OI Xu, Xiaojun/0000-0003-4379-8748; Qian, Cheng/0000-0001-7573-3717
FU Chinese National Science Foundation [81773957]; National Science and
   Technology Major Projects for "Major New Drugs Innovation and
   Development" [2018ZX09201001-001-001]; Priority Academic Program
   Development of Jiangsu Higher Education Institutions (PAPD); 111 Project
   [B16046]; Project Program of State Key Laboratory of Natural Medicines,
   China Pharmaceutical University [SKLNMZZCX201820]
FX This work was supported by the Chinese National Science Foundation
   (81773957), National Science and Technology Major Projects for "Major
   New Drugs Innovation and Development" (2018ZX09201001-001-001), the
   Priority Academic Program Development of Jiangsu Higher Education
   Institutions (PAPD), 111 Project (no. B16046). This study also was
   supported by the Project Program of State Key Laboratory of Natural
   Medicines, China Pharmaceutical University (No. SKLNMZZCX201820).
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Z9 30
U1 5
U2 53
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD FEB
PY 2019
VL 110
BP 571
EP 581
DI 10.1016/j.biopha.2018.12.003
PG 11
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA HG3MW
UT WOS:000454879800061
PM 30537674
OA gold
DA 2025-06-11
ER

PT J
AU Vitale, JA
   Lombardi, G
   Weydahl, A
   Banfi, G
AF Vitale, Jacopo Antonino
   Lombardi, Giovanni
   Weydahl, Andi
   Banfi, Giuseppe
TI Biological rhythms, chronodisruption and chrono-enhancement: The role of
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   rhythm in metabolic dysfunctions and cancer
SO CHRONOBIOLOGY INTERNATIONAL
LA English
DT Article
DE Circadian rhythm; synchronizer; physical activity; inflammation; cancer
ID DIURNAL SALIVARY CORTISOL; HIGH-FAT DIET; DEHYDROEPIANDROSTERONE-SULFATE
   DHEAS; RANDOMIZED CONTROLLED-TRIAL; ACTIGRAPHY-BASED ACROPHASE;
   PITUITARY-ADRENAL AXIS; SKELETAL-MUSCLE CELLS; BREAST-CANCER;
   CARDIOVASCULAR-DISEASE; COLORECTAL-CANCER
AB Rhythms can be observed at all levels of the biologic integration in humans. The observation that a biological or physiological variable shows a circadian rhythm can be explained by several multifactorial systems including external (exogenous), internal (endogenous) and psychobiological (lifestyle) mechanisms. Our body clock can be synchronized with the environment by external factors, called "synchronizers", i.e. the light-dark cycle, but it is also negatively influenced by some pathological conditions or factors, called "chronodisruptors," i.e. aging or low physical activity (PA). The desynchronization of a 24-h rhythm in a chronic manner has been recently defined "chronodisruption" or "circadian disruption." A very large number of hormonal variables, such as adrenal and gonadal stress steroids, are governed by circadian rhythmicity. Such hormones, in normal conditions, show a peak in the first part of the day, while their typical diurnal fluctuations are totally out of sync in subjects affected by cancer or metabolic diseases, such as obesity, diabetes and metabolic syndrome. In general, a flatter slope with altered peaks in cortisol and testosterone circadian rhythms has been observed in pathological individuals. PA, specifically chronic exercise, seems to play a key role as synchronizer for the whole circadian system in such pathologies even if specific data on steroids circadian pattern are still sparse and contradictory. Recently, it has been proposed that low-intensity chronic PA could be an effective intervention to decrease morning cortisol levels in pathological subjects. The standardization of all confounding factors is needed to reach more clear evidence-based results.
C1 [Vitale, Jacopo Antonino] IRCCS Ist Ortoped Galeazzi, Lab Biol Struct Biomech, Milan, Italy.
   [Lombardi, Giovanni; Banfi, Giuseppe] IRCCS Ist Ortoped Galeazzi, Lab Expt Biochem & Mol Biol, Milan, Italy.
   [Weydahl, Andi] UiT Arctic Univ Norway, Alta, Norway.
   [Banfi, Giuseppe] Univ Vita Salute San Raffaele, Milan, Italy.
C3 IRCCS Istituto Ortopedico Galeazzi; IRCCS Istituto Ortopedico Galeazzi;
   UiT The Arctic University of Tromso; Vita-Salute San Raffaele University
RP Vitale, JA (corresponding author), IRCCS IST Ortoped Galeazzi, Via Riccardo Galeazzi 4, I-20161 Milan, Italy.
EM jacopo.vitale@grupposandonato.it
RI Lombardi, Giovanni/I-2414-2012; Vitale, Jacopo Antonino/B-1758-2017;
   Banfi, Giuseppe/K-6585-2015
OI Vitale, Jacopo Antonino/0000-0002-7537-079X; Lombardi,
   Giovanni/0000-0002-8365-985X; Banfi, Giuseppe/0000-0001-9578-5338
FU Italian Ministry of Health
FX This work was supported by the Italian Ministry of Health
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NR 151
TC 33
Z9 34
U1 0
U2 15
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 0742-0528
EI 1525-6073
J9 CHRONOBIOL INT
JI Chronobiol. Int.
PY 2018
VL 35
IS 9
BP 1185
EP 1197
DI 10.1080/07420528.2018.1475395
PG 13
WC Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics; Physiology
GA GY5FJ
UT WOS:000448596700001
PM 29953265
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Wijarnpreecha, K
   Panjawatanan, P
   Lekuthai, N
   Thongprayoon, C
   Cheungpasitporn, W
   Ungprasert, P
AF Wijarnpreecha, Karn
   Panjawatanan, Panadeekarn
   Lekuthai, Natasorn
   Thongprayoon, Charat
   Cheungpasitporn, Wisit
   Ungprasert, Patompong
TI Hyperuricaemia and risk of nonalcoholic fatty liver disease: A
   meta-analysis
SO LIVER INTERNATIONAL
LA English
DT Article
DE hyperuricaemia; meta-analysis; nonalcoholic fatty liver disease;
   nonalcoholic steatohepatitis
ID SERUM URIC-ACID; METABOLIC SYNDROME; UNITED-STATES; ANTIOXIDANT
   CAPACITY; HEPATIC STEATOSIS; OXIDATIVE STRESS; NATIONAL-HEALTH; CHINESE
   ADULTS; PREVALENCE; ASSOCIATION
AB Background: The association between hyperuricaemia and nonalcoholic fatty liver disease (NAFLD), one of the leading causes of cirrhosis worldwide, has been demonstrated in recent epidemiological studies. This meta-analysis was conducted to summarize all available data and to estimate the risk of NAFLD among subjects with hyperuricaemia.
   Methods: Comprehensive literature review was conducted using MEDLINE and EMBASE database through August 2016 to identify studies that compared the risk of NAFLD among subjects with hyperuricaemia vs those with normal uric acid level. Effect estimates from individual study were extracted and combined together using random-effect, generic inverse variance method of DerSimonian and Laird.
   Results: Twenty-five studies met the eligibility criteria and were included in the meta-analysis. The risk of NAFLD in subjects with hyperuricaemia was significantly higher than subjects with normal uric acid level with the pooled odds ratio (OR) of 1.97 (95% confidence interval (CI), 1.69-2.29). The heterogeneity between studies of the overall analysis was high with an I-2 of 87%. Subgroup analysis based on 11 studies that provided data on males subgroup and nine studies that provided data on females subgroup showed that the risk was significantly increased for both sexes with pooled OR of 1.64 (95% CI, 1.40-1.93) among males and pooled OR of 2.21 (95% CI, 1.85-2.64) among females.
   Conclusions: A significantly increased risk of NAFLD among patients with hyperuricaemia was demonstrated in this meta-analysis. Further studies are required to establish the role of uric acid in the pathogenesis of NAFLD.
C1 [Wijarnpreecha, Karn; Thongprayoon, Charat] Bassett Med Ctr, Dept Internal Med, Cooperstown, NY 13326 USA.
   [Panjawatanan, Panadeekarn] Chiang Mai Univ, Fac Med, Dept Biochem, Chiang Mai, Thailand.
   [Lekuthai, Natasorn; Ungprasert, Patompong] Mahidol Univ, Siriraj Hosp, Fac Med, Dept Med, Bangkok, Thailand.
   [Cheungpasitporn, Wisit; Ungprasert, Patompong] Mayo Clin, Dept Med, Rochester, MN USA.
C3 Chiang Mai University; Mahidol University; Mayo Clinic
RP Wijarnpreecha, K (corresponding author), Bassett Med Ctr, Dept Internal Med, Cooperstown, NY 13326 USA.
EM dr.karn.wi@gmail.com
RI Thongprayoon, Charat/J-4184-2019; Panjawatanan,
   Panadeekarn/HRA-8711-2023; Wijarnpreecha, Karn/J-3296-2019;
   Cheungpasitporn, Wisit/H-8194-2019
OI Wijarnpreecha, Karn/0000-0002-6232-6343
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NR 67
TC 42
Z9 44
U1 0
U2 21
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1478-3223
EI 1478-3231
J9 LIVER INT
JI Liver Int.
PD JUN
PY 2017
VL 37
IS 6
BP 906
EP 918
DI 10.1111/liv.13329
PG 13
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA EY4BK
UT WOS:000403921100018
PM 27891768
DA 2025-06-11
ER

PT J
AU Leitner, LM
   Wilson, RJ
   Yan, Z
   Gödecke, A
AF Leitner, Lucia M.
   Wilson, Rebecca J.
   Yan, Zhen
   Goedecke, Axel
TI Reactive Oxygen Species/Nitric Oxide Mediated Inter-Organ Communication
   in Skeletal Muscle Wasting Diseases
SO ANTIOXIDANTS & REDOX SIGNALING
LA English
DT Review
DE angiotensin; autophagy; cachexia; exercise; skeletal muscle; ubiquitin
ID CHRONIC HEART-FAILURE; ANGIOTENSIN-II; NITRIC-OXIDE;
   PROTEIN-DEGRADATION; XANTHINE-OXIDASE; OXIDATIVE STRESS; NAD(P)H
   OXIDASE; FIBER-TYPE; ISCHEMIA/REPERFUSION INJURY; MITOCHONDRIAL
   DYSFUNCTION
AB Significance: Cachexia is defined as a complex metabolic syndrome that is associated with underlying illness and a loss of muscle with or without loss of fat mass. This disease is associated with a high incidence with chronic diseases such as heart failure, cancer, chronic obstructive pulmonary disease (COPD), and acquired immunodeficiency syndrome (AIDS), among others. Since there is currently no effective treatment available, cachectic patients have a poor prognosis. Elucidation of the underlying mechanisms is, therefore, an important medical task.
   Recent Advances: There is accumulating evidence that the diseased organs such as heart, lung, kidney, or cancer tissue secrete soluble factors, including Angiotensin II, myostatin (growth differentiation factor 8 [GDF8]), GDF11, tumor growth factor beta (TGF beta), which act on skeletal muscle. There, they induce a set of genes called atrogenes, which, among others, induce the ubiquitin-proteasome system, leading to protein degradation. Moreover, elevated reactive oxygen species (ROS) levels due to modulation of NADPH oxidases (Nox) and mitochondrial function contribute to disease progression, which is characterized by loss of muscle mass, exercise resistance, and frailty.
   Critical issues: Although substantial progress was achieved to elucidate the pathophysiology of cachexia, effectice therapeutic strategies are urgently needed.
   Future Directions: With the identification of key components of the aberrant inter-organ communication leading to cachexia, studies in mice and men to inhibit ROS formation, induction of anti-oxidative superoxide dismutases, and upregulation of muscular nitric oxide (NO) formation either by pharmacological tools or by exercise are promising approaches to reduce the extent of skeletal muscle wasting.
C1 [Leitner, Lucia M.; Goedecke, Axel] Heinrich Heine Univ Dusseldorf, Inst Herz & Kreislaufphysiol, Univ Klinikum, Postfach 101007, D-40001 Dusseldorf, Germany.
   [Wilson, Rebecca J.; Yan, Zhen] Univ Virginia, Dept Med Cardiovasc Med, Charlottesville, VA USA.
   [Yan, Zhen] Univ Virginia, Ctr Skeletal Muscle Res, Robert Berne Cardiovasc Res Ctr, Charlottesville, VA USA.
C3 Heinrich Heine University Dusseldorf; University of Virginia; University
   of Virginia
RP Gödecke, A (corresponding author), Heinrich Heine Univ Dusseldorf, Inst Herz & Kreislaufphysiol, Univ Klinikum, Postfach 101007, D-40001 Dusseldorf, Germany.
EM axel.goedecke@hhu.de
OI Wilson, Rebecca/0000-0001-5884-0705; Yan, Zhen/0000-0002-4826-9813
FU grant of the Deutsche Forschungsgemeinschaft (DFG) via International
   Research Training Group [IRTG1902]; National Institutes of Health
   [R01GM109473]
FX This work was supported by a grant of the Deutsche
   Forschungsgemeinschaft (DFG) via International Research Training Group
   IRTG1902 to A.G. and partially supported by the National Institutes of
   Health R01GM109473 to Z.Y.
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NR 151
TC 39
Z9 41
U1 1
U2 32
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1523-0864
EI 1557-7716
J9 ANTIOXID REDOX SIGN
JI Antioxid. Redox Signal.
PD MAY 1
PY 2017
VL 26
IS 13
BP 700
EP 717
DI 10.1089/ars.2016.6942
PG 18
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA ET0ME
UT WOS:000399955700002
PM 27835923
OA Green Published
DA 2025-06-11
ER

PT J
AU Kiedrowski, M
   Waugh, S
   Miller, R
   Johnson, C
   Krajnak, K
AF Kiedrowski, Megan
   Waugh, Stacey
   Miller, Roger
   Johnson, Claud
   Krajnak, Kristine
TI The effects of repetitive vibration on sensorineural function:
   biomarkers of sensorineural injury in an animal model of metabolic
   syndrome
SO BRAIN RESEARCH
LA English
DT Article
DE Zucker rat; Metabolic disorder; Hyperalgesia; Neuropathic pain
ID FREQUENCY-DEPENDENT RESPONSES; NERVE-CONDUCTION VELOCITY; PERCEPTION
   THRESHOLD; VASCULAR SYSTEM; GENE-EXPRESSION; STRESS; ALTERS; TESTS; RAT;
   HYPERALGESIA
AB Exposure to hand-transmitted vibration in the work-place can result in the loss of sensation and pain in workers. These effects may be exacerbated by pre-existing conditions such as diabetes or the presence of primary Raynaud's phenomena. The goal of these studies was to use an established model of vibration-induced injury in Zucker rats. Lean Zucker rats have a normal metabolic profile, while obese Zucker rats display symptoms of metabolic disorder or Type II diabetes. This study examined the effects of vibration in obese and lean rats. Zucker rats were exposed to 4 h of vibration for 10 consecutive days at a frequency of 125 Hz and acceleration of 49 m/s(2) for 10 consecutive days. Sensory function was checked using transcutaneous electrical stimulation on days 1, 5 and 9 of the exposure. Once the study was complete the ventral tail nerves, dorsal root ganglia and spinal cord were dissected, and levels of various transcripts involved in sensorineural dysfunction were measured. Sensorineural dysfunction was assessed using transcutaneous electrical stimulation. Obese Zucker rats displayed very few changes in sensorineural function. However they did display significant changes in transcript levels for factors involved in synapse formation, peripheral nerve remodeling, and inflammation. The changes in transcript levels suggested that obese Zucker rats had some level of sensory nerve injury prior to exposure, and that exposure to vibration activated pathways involved in injury and re-innervation. Published by Elsevier B.V.
C1 [Kiedrowski, Megan; Waugh, Stacey; Miller, Roger; Johnson, Claud; Krajnak, Kristine] NIOSH, Morgantown, WV 26505 USA.
   [Kiedrowski, Megan; Waugh, Stacey; Miller, Roger; Johnson, Claud; Krajnak, Kristine] NIOSH, Effects Lab Div, Morgantown, WV 26505 USA.
C3 Centers for Disease Control & Prevention - USA; National Institute for
   Occupational Safety & Health (NIOSH); Centers for Disease Control &
   Prevention - USA; National Institute for Occupational Safety & Health
   (NIOSH)
RP Krajnak, K (corresponding author), NIOSH, 1095 Willowdale Rd, Morgantown, WV 26505 USA.
EM ksk1@cdc.gov
OI Kiedrowski, Megan/0000-0003-4610-182X
FU Health Effects Laboratory Division, National Institute for Occupational
   Safety and Health
FX This research was funded through intramural funding from the Health
   Effects Laboratory Division, National Institute for Occupational Safety
   and Health.
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   Xiang LS, 2008, AM J PHYSIOL-HEART C, V294, pH1658, DOI 10.1152/ajpheart.01206.2007
NR 46
TC 3
Z9 5
U1 0
U2 4
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0006-8993
EI 1872-6240
J9 BRAIN RES
JI Brain Res.
PD NOV 19
PY 2015
VL 1627
BP 216
EP 224
DI 10.1016/j.brainres.2015.09.026
PG 9
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA CY2HC
UT WOS:000366228400020
PM 26433044
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Ryckman, KK
   Spracklen, CN
   Smith, CJ
   Robinson, JG
   Saftlas, AF
AF Ryckman, K. K.
   Spracklen, C. N.
   Smith, C. J.
   Robinson, J. G.
   Saftlas, A. F.
TI Maternal lipid levels during pregnancy and gestational diabetes: a
   systematic review and meta-analysis
SO BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
LA English
DT Review
DE Dyslipidaemia; gestational diabetes mellitus; hypertriglyceridaemia;
   lipid; pregnancy; triglycerides
ID INSULIN-RESISTANCE; ADIPOSE-TISSUE; BIRTH-WEIGHT; SERUM TRIGLYCERIDE;
   LIPOPROTEIN-LIPASE; ANTIOXIDANT STATUS; METABOLIC SYNDROME;
   GLUCOSE-TOLERANCE; OXIDATIVE STRESS; HIGH-RISK
AB BackgroundLipid levels during pregnancy in women with gestational diabetes mellitus (GDM) have been extensively studied; however, it remains unclear whether dyslipidaemia is a potential marker of preexisting insulin resistance.
   ObjectiveTo evaluate the relationship between lipid measures throughout pregnancy and GDM.
   Search strategyWe searched PubMed-MedLine and SCOPUS (inception until January 2014) and reference lists of relevant studies.
   Selection criteriaPublications describing original data with at least one raw lipid (total cholesterol, high-density lipoprotein cholesterol [HDL-C], low-density lipoprotein cholesterol [LDL-C], or triglyceride) measurement during pregnancy in women with GDM and healthy pregnant controls were retained.
   Data collection and analysisData extracted from 60 studies were pooled and weighted mean difference (WMD) in lipid levels was calculated using random effects models. Meta-regression was also performed to identify sources of heterogeneity.
   Main resultsTriglyceride levels were significantly elevated in women with GDM compared with those without GDM (WMD 30.9, 95% confidence interval [95% CI] 25.4-36.4). This finding was consistent in the first, second and third trimesters of pregnancy. HDL-C levels were significantly lower in women with GDM compared with those without GDM in the second (WMD -4.6, 95% CI -6.2 to -3.1) and third (WMD -4.1, 95% CI -6.5 to -1.7) trimesters of pregnancy. There were no differences in aggregate total cholesterol or LDL-C levels between women with GDM and those without insulin resistance.
   Author's conclusionsOur meta-analysis shows that triglycerides are significantly elevated among women with GDM compared with women without insulin resistance and this finding persists across all three trimesters of pregnancy.
C1 [Ryckman, K. K.; Spracklen, C. N.; Smith, C. J.; Robinson, J. G.; Saftlas, A. F.] Univ Iowa, Coll Publ Hlth, Dept Epidemiol, Iowa City, IA 52242 USA.
C3 University of Iowa
RP Ryckman, KK (corresponding author), Univ Iowa, Coll Publ Hlth, Dept Epidemiol, 145 N Riverside Dr,S435 CPHB, Iowa City, IA 52242 USA.
EM kelli-ryckman@uiowa.edu
RI , Jennifer/AAD-8336-2019
OI Ryckman, Kelli/0000-0002-9496-4147
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NR 88
TC 275
Z9 308
U1 1
U2 42
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1470-0328
EI 1471-0528
J9 BJOG-INT J OBSTET GY
JI BJOG
PD APR
PY 2015
VL 122
IS 5
BP 643
EP 651
DI 10.1111/1471-0528.13261
PG 9
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA CE2XZ
UT WOS:000351686700011
PM 25612005
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Cayli, M
   Gür, M
   Kalkan, GY
   Elbasan, Z
   Sahin, DY
   Koyunsever, NY
   Türkoglu, C
   Seker, T
   Kaypakli, O
   Harbalioglu, H
   Uçar, H
AF Cayli, M.
   Gur, M.
   Kalkan, G. Y.
   Elbasan, Z.
   Sahin, D. Y.
   Koyunsever, N. Y.
   Turkoglu, C.
   Seker, T.
   Kaypakli, O.
   Harbalioglu, H.
   Ucar, H.
TI Gamma glutamyl transferase activity Relationship with thoracic aortic
   intima media thickness and inflammation
SO HERZ
LA English
DT Article
DE Aorta; Intima media thickness; Atherosclerosis; Gamma-glutamyl
   transferase; Predictor
ID CORONARY-ARTERY-DISEASE; C-REACTIVE PROTEIN; OXIDATIVE STRESS;
   CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; ATHEROSCLEROSIS;
   ASSOCIATION; RISK; ADULTS; MARKER
AB Objective. Increased serum gamma-glutamyl transferase (GGT) activity is known to be associated with atherosclerotic diseases. Thoracic aortic intima-media thickness (IMT) was reported as a marker of preclinical atherosclerosis. However, there is a lack of research directly examining the relationship between serum GGT activity and thoracic aortic IMT. Therefore, we aimed to investigate the association between serum GGT activity and thoracic aortic IMT.
   Patients and methods. The study population consisted of 329 patients without coronary artery disease, who underwent transesophageal echocardiography (TEE) examination for various indications from January 2011 to April 2013. GGT, high-sensitivity C-reactive protein (hs-CRP) and other biochemical markers were measured in all patients. The patients were classified into tertiles according to their GGT activities (GGT(low) <19 U/l, GGT(mid) >= 19 U/l <29 U/l, and GGT(high) >= 29).
   Results. The highest aortic IMT values were observed in the GGT(high) group compared with the GGT(mid) and GGT(low) groups (p<0.05, for all). Also, aortic IMT values in the GGT(mid) group were higher than in the GGT(low) group (p<0.05). Multivariate regression analysis showed that GGT activity was independently associated with aortic IMT (beta=0.487, p<0.001) hs-CRP (beta=0.282, p<0.001), and triglyceride level (beta=0.161, p=0.007).
   Conclusion. The higher serum GGT concentrations within the "normal" range were associated with a greater IMT of the thoracic aorta. GGT activity may be a predictor of the extent of subclinical aortic atherosclerosis assessed with thoracic aortic IMT.
C1 [Cayli, M.; Gur, M.; Kalkan, G. Y.; Elbasan, Z.; Sahin, D. Y.; Koyunsever, N. Y.; Turkoglu, C.; Seker, T.; Kaypakli, O.; Harbalioglu, H.; Ucar, H.] Adana Numune Training & Res Hosp, Dept Cardiol, Cukurova, Turkey.
C3 Ankara Numune Training & Research Hospital; Adana Numune Training &
   Research Hospital
RP Sahin, DY (corresponding author), Adana Numune Training & Res Hosp, Dept Cardiol, TR-01170 Adana, Turkey.
EM dysahin79@hotmail.com
RI KAYPAKLI, ONUR/AFL-2748-2022; Ucar, Hakan/AEV-3738-2022
CR Aksakal E, 2012, ATHEROSCLEROSIS, V221, P596, DOI 10.1016/j.atherosclerosis.2012.01.044
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NR 32
TC 4
Z9 5
U1 0
U2 2
PU URBAN & VOGEL
PI MUNICH
PA NEUMARKTER STRASSE 43, D-81673 MUNICH, GERMANY
SN 0340-9937
EI 1615-6692
J9 HERZ
JI Herz
PD SEP
PY 2014
VL 39
IS 6
BP 761
EP 766
DI 10.1007/s00059-013-3921-0
PG 6
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA AR5XJ
UT WOS:000343654300022
PM 23934197
DA 2025-06-11
ER

PT J
AU Colpo, E
   Vilanova, CDDA
   Reetz, LGB
   Duarte, MMMF
   Farias, ILG
   Meinerz, DE
   Mariano, DOC
   Vendrusculo, RG
   Boligon, AA
   Corte, CLD
   Wagner, R
   Athayde, ML
   Da Rocha, JBT
AF Colpo, Elisangela
   Vilanova, Carlos Dalton D. A.
   Reetz, Luiz Gustavo B.
   Duarte, Marta M. M. F.
   Farias, Iria Luiza G.
   Meinerz, Daiane E.
   Mariano, Douglas O. C.
   Vendrusculo, Raquel G.
   Boligon, Aline A.
   Corte, Cristiane L. Dalla
   Wagner, Roger
   Athayde, Margareth L.
   da Rocha, Joao Batista T.
TI Brazilian nut consumption by healthy volunteers improves inflammatory
   parameters
SO NUTRITION
LA English
DT Article
DE Human; Interleukin; Unsaturated fatty acids; Selenium; C-reactive
   protein; Nutrition; Oxidative stress
ID CARDIOVASCULAR RISK-FACTORS; MEDITERRANEAN-STYLE DIET; IMMUNE CELL
   FUNCTIONS; ENDOTHELIAL FUNCTION; METABOLIC SYNDROME; RANDOMIZED-TRIAL;
   FATTY-ACIDS; OLIVE OIL; SELENIUM; SUPPLEMENTATION
AB Objective: The aim of this study was to investigate the effect of a single dose of Brazil nuts on the inflammatory markers of healthy individuals.
   Method: A randomized crossover study was conducted with 10 healthy individuals (mean age 24.7 +/- 3.4 y). Each individual was tested four times regarding intake of different portions of Brazil nuts: 0, 5,20 and 50g. At each testing period, peripheral blood was collected before and at 1, 3, 6, 9, 24, and 48 h after intake of nuts, as well as at 5 and 30 d after intake of various Brazil nut portions. Blood samples were tested for high-sensitivity to C-reactive protein, interleukin (IL)-1, IL-6, IL-10, tumor necrosis factor (TNF)-alpha, and interferon (IFN)-gamma, aspartate and alanine aminotransferases, albumin, total protein, alkaline phosphatase, gamma-glutamyltransferase, urea, and creatinine.
   Results: Consumption of nuts did not affect biochemical parameters for liver and kidney function, indicating absence of hepatic and renal toxicity. A single intake of Brazil nuts (20 or 50 g) caused a significant decrease in serum IL-1, IL-6, TNF-alpha, and IFN-gamma levels (P < 0.05), whereas serum levels of IL-10 were significantly increased (P < 0.05).
   Conclusion: The results indicate a long-term decrease in inflammatory markers after a single intake of large portions of Brazil nuts in healthy volunteers. Therefore, the long-term effect of regular Brazil nut consumption on inflammatory markers should be better investigated. (C) 2014 Elsevier Inc. All rights reserved.
C1 [Colpo, Elisangela; Vilanova, Carlos Dalton D. A.; Duarte, Marta M. M. F.; Meinerz, Daiane E.; Mariano, Douglas O. C.; Corte, Cristiane L. Dalla; da Rocha, Joao Batista T.] Univ Fed Santa Maria, Nat & Exact Sci Ctr, Dept Biochem & Mol Biol, BR-97119900 Santa Maria, RS, Brazil.
   [Reetz, Luiz Gustavo B.; Farias, Iria Luiza G.] Univ Fed Santa Maria, Univ Hosp, Clin Lab Anal, BR-97119900 Santa Maria, RS, Brazil.
   [Colpo, Elisangela] Ctr Franciscan Univ, Dept Nutr, Santa Maria, RS, Brazil.
   [Duarte, Marta M. M. F.] Univ Luterana Brasil, Santa Maria, RS, Brazil.
   [Vendrusculo, Raquel G.; Wagner, Roger] Univ Fed Santa Maria, Dept Technol & Food & Sci, BR-97119900 Santa Maria, RS, Brazil.
   [Boligon, Aline A.; Athayde, Margareth L.] Univ Fed Santa Maria, Dept Ind Pharm, BR-97119900 Santa Maria, RS, Brazil.
C3 Universidade Federal de Santa Maria (UFSM); Universidade Federal de
   Santa Maria (UFSM); Universidade Luterana do Brasil; Universidade
   Federal de Santa Maria (UFSM); Universidade Federal de Santa Maria
   (UFSM)
RP Da Rocha, JBT (corresponding author), Univ Fed Santa Maria, Nat & Exact Sci Ctr, Dept Biochem & Mol Biol, BR-97119900 Santa Maria, RS, Brazil.
EM Jbtrocha@pq.cnpq.br
RI Vendruscolo, Raquel/ABG-1961-2021; Mariano, Douglas/F-4277-2014; Rocha,
   Joao Batista Teixeira da/S-6813-2016; Wagner, Roger/I-1538-2014; Colpo,
   Elisangela/Q-1683-2016; Lenz Dalla Corte, Cristiane/J-3050-2012
OI Rocha, Joao Batista Teixeira da/0000-0003-3829-0595; Guidetti
   Vendruscolo, Raquel/0000-0002-3867-7602; Wagner,
   Roger/0000-0002-6176-7913; Colpo, Elisangela/0000-0002-3886-0765;
   Mariano, Douglas/0000-0001-7296-5475; Lenz Dalla Corte,
   Cristiane/0000-0003-3478-626X; de Avila Vilanova, Carlos
   Dalton/0000-0002-5363-7000
FU National Counsel of Technological and Scientific Development (CNPq)
FX This work was financed by grants received from the National Counsel of
   Technological and Scientific Development (CNPq).
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NR 48
TC 52
Z9 60
U1 0
U2 29
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0899-9007
EI 1873-1244
J9 NUTRITION
JI Nutrition
PD APR
PY 2014
VL 30
IS 4
BP 459
EP 465
DI 10.1016/j.nut.2013.10.005
PG 7
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA AD8UZ
UT WOS:000333542500015
PM 24607303
DA 2025-06-11
ER

PT J
AU Tomada, I
   Negrao, R
   Almeida, H
   Neves, D
AF Tomada, I.
   Negrao, R.
   Almeida, H.
   Neves, D.
TI Long-term high-fat consumption leads to downregulation of Akt
   phosphorylation of eNOS at Ser1177 and upregulation of Sirtuin-1
   expression in rat cavernous tissue
SO AGE
LA English
DT Article
DE Aging; Cavernous tissue; Nitric oxide synthase; Energy restriction;
   High-fat diet; Sirtuin-1
ID NITRIC-OXIDE SYNTHASE; ENDOTHELIAL DYSFUNCTION; ERECTILE DYSFUNCTION;
   METABOLIC SYNDROME; CALORIE RESTRICTION; OXIDATIVE STRESS; ENERGY
   RESTRICTION; ARTERY-DISEASE; SIRT1; CORONARY
AB Long-term consumption of high-fat diets negatively interferes with metabolic status and promotes endothelial dysfunction and inflammation. In the cavernous tissue, these outcomes become conspicuous in the elderly and strongly affect penile erection, a vascular process highly dependent on local nitric oxide bioavailability. Although epidemiological data links erectile dysfunction to nutritional patterns, the underlying molecular mechanisms remain unclear. Therefore, we investigated the effects of long-term high-fat diet on endothelial nitric oxide synthase (eNOS)-Sirtuin-1 axis and Akt/eNOS phosphorylation in the cavernous tissue of Sprague-Dawley rats, and compared with energy-restricted animals. We demonstrated that high-fat diet intake led to a noteworthy decrease in eNOS phosphorylation at Ser1177 residue through the Akt pathway, which seems to be compensated by upregulation of phosphorylation at Ser615, but without an increment in nitric oxide production. These results are accompanied by an increase of systemic inflammatory markers and upregulation of the inducible NOS and of the deacetylase Sirtuin-1 in the cavernous tissue to levels apparently detrimental to cells and to metabolic homeostasis. Conversely, in long-term energy-restricted animals, the rate of phosphorylation of eNOS at Ser1177 diminished, but the activation of the enzyme increased through phosphorylation of eNOS at Ser615, resulting in an enhancement in nitric oxide bioavailability. Taken together, our results demonstrate that long-term nutritional conditions override the influence of age on the eNOS expression and activation in rat cavernous tissue.
C1 [Tomada, I.; Almeida, H.; Neves, D.] Univ Porto, Dept Expt Biol, Fac Med, P-4200319 Oporto, Portugal.
   [Tomada, I.; Almeida, H.; Neves, D.] Univ Porto, IBMC, P-4150180 Oporto, Portugal.
   [Negrao, R.] Univ Porto, Fac Med, Dept Biochem FCT U38, P-4200319 Oporto, Portugal.
C3 Universidade do Porto; Universidade do Porto; Universidade do Porto
RP Tomada, I (corresponding author), Univ Porto, Dept Expt Biol, Fac Med, Alameda Prof Hernani Monteiro, P-4200319 Oporto, Portugal.
EM inestomada@gmail.com
RI Almeida, Hugo/H-7076-2017; Negrao, Rita/L-2982-2013
OI Neves, Delminda/0000-0002-3301-8376; Tomada, Ines/0000-0003-4660-0645;
   Negrao, Rita/0000-0002-0733-4412; Almeida, Henrique/0000-0002-3036-3211
FU Fundacao para a Ciencia e Tecnologia, Portugal-Pluriannual; 
   [SFRH/BD/46009/2008]; Fundação para a Ciência e a Tecnologia
   [SFRH/BD/46009/2008] Funding Source: FCT
FX This study was supported by Fundacao para a Ciencia e Tecnologia,
   Portugal-Pluriannual funding and SFRH/BD/46009/2008.
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NR 74
TC 6
Z9 7
U1 0
U2 10
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0161-9152
EI 1574-4647
J9 AGE
JI Age
PD APR
PY 2014
VL 36
IS 2
BP 597
EP 611
DI 10.1007/s11357-013-9591-2
PG 15
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA AD2FG
UT WOS:000333048600009
PM 24105250
OA Green Published
DA 2025-06-11
ER

PT J
AU Mela, V
   Llorente-Berzal, A
   Díaz, F
   Argente, J
   Viveros, MP
   Chowen, JA
AF Mela, Virginia
   Llorente-Berzal, Alvaro
   Diaz, Francisca
   Argente, Jesus
   Viveros, Maria-Paz
   Chowen, Julie A.
TI Maternal Deprivation Exacerbates the Response to a High Fat Diet in a
   Sexually Dimorphic Manner
SO PLOS ONE
LA English
DT Article
ID METABOLIC SYNDROME; GLUCOCORTICOID METABOLISM; INSULIN SENSITIVITY;
   GENE-EXPRESSION; INDUCED OBESITY; LEPTIN SURGE; BODY-WEIGHT; FEMALE
   RATS; FOOD-INTAKE; ADOLESCENT
AB Maternal deprivation (MD) during neonatal life has diverse long-term effects, including affectation of metabolism. Indeed, MD for 24 hours during the neonatal period reduces body weight throughout life when the animals are maintained on a normal diet. However, little information is available regarding how this early stress affects the response to increased metabolic challenges during postnatal life. We hypothesized that MD modifies the response to a high fat diet (HFD) and that this response differs between males and females. To address this question, both male and female Wistar rats were maternally deprived for 24 hours starting on the morning of postnatal day (PND) 9. Upon weaning on PND22 half of each group received a control diet (CD) and the other half HFD. MD rats of both sexes had significantly reduced accumulated food intake and weight gain compared to controls when raised on the CD. In contrast, when maintained on a HFD energy intake and weight gain did not differ between control and MD rats of either sex. However, high fat intake induced hyperleptinemia in MD rats as early as PND35, but not until PND85 in control males and control females did not become hyperleptinemic on the HFD even at PND102. High fat intake stimulated hypothalamic inflammatory markers in both male and female rats that had been exposed to MD, but not in controls. Reduced insulin sensitivity was observed only in MD males on the HFD. These results indicate that MD modifies the metabolic response to HFD intake, with this response being different between males and females. Thus, the development of obesity and secondary complications in response to high fat intake depends on numerous factors.
C1 [Mela, Virginia; Llorente-Berzal, Alvaro; Viveros, Maria-Paz] Univ Complutense, Fac Biol, Dept Physiol Anim Physiol 2, Inst Invest Sanitaria,Hosp Clin San Carlos, E-28040 Madrid, Spain.
   [Diaz, Francisca; Argente, Jesus; Chowen, Julie A.] Hosp Infantil Univ Nino Jesus, Dept Endocrinol, Inst Invest Biomed Princesa, Madrid, Spain.
   [Argente, Jesus] Univ Autonoma Madrid, Dept Pediat, Madrid, Spain.
   [Diaz, Francisca; Argente, Jesus; Chowen, Julie A.] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr, Madrid, Spain.
C3 Complutense University of Madrid; Hospital Clinico San Carlos;
   Autonomous University of Madrid; CIBER - Centro de Investigacion
   Biomedica en Red; CIBEROBN; Instituto de Salud Carlos III
RP Viveros, MP (corresponding author), Univ Complutense, Fac Biol, Dept Physiol Anim Physiol 2, Inst Invest Sanitaria,Hosp Clin San Carlos, E-28040 Madrid, Spain.
EM pazviver@bio.ucm.es; julieann.chowen@madrid.salud.org
RI Argente, Jesús/M-5226-2019; Mela, Virginia/N-4664-2017; Chowen,
   Julie/C-8979-2011; Llorente-Berzal, Alvaro/C-8232-2018; Argente,
   Jesus/L-2928-2013; Viveros, Maria-Paz/S-6855-2016
OI Mela, Virginia/0000-0001-7702-0972; Chowen, Julie/0000-0002-4770-2291;
   Llorente-Berzal, Alvaro/0000-0002-9787-2619; Argente,
   Jesus/0000-0001-5826-0276; Viveros, Maria-Paz/0000-0002-4119-4636;
   Diaz-Gonzalez, Francisca/0000-0003-1364-7586
FU Fondos de Investigacion Sanitaria [PI10 / 00747]; CIBER Fisiopatologia
   de Obesidad y Nutricion Instituto de Salud Carlos III; Ministerio de
   Ciencia e innovacion [BFU2009-10109, BFU2011-27492]; GRUPOS UCM-BSCH
   [GRUPO UCM951579]; Fundacion de Endocrinologia y Nutricion; Red de
   Trastornos Adictivos [RD06 / 0001/1013]
FX This work was funded by grants from Fondos de Investigacion Sanitaria
   (PI10 / 00747), CIBER Fisiopatologia de Obesidad y Nutricion Instituto
   de Salud Carlos III, Ministerio de Ciencia e innovacion: (BFU2009-10109,
   subprograma BFI and BFU2011-27492), GRUPOS UCM-BSCH (GRUPO UCM951579)
   and Fundacion de Endocrinologia y Nutricion. VM is supported by Red de
   Trastornos Adictivos RD06 / 0001/1013. The funders had no role in study
   design, data collection and analysis, decision to publish, or
   preparation of the manuscript.
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NR 53
TC 33
Z9 35
U1 0
U2 9
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD NOV 7
PY 2012
VL 7
IS 11
AR e48915
DI 10.1371/journal.pone.0048915
PG 13
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 048TK
UT WOS:000311935800168
PM 23145019
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Esbah, O
   Gürsoy, G
   Kirnap, NG
   Cetiner, H
   Demirbas, B
   Acar, Y
   Bayram, M
AF Esbah, Onur
   Gursoy, Gul
   Kirnap, Nazli Gulsoy
   Cetiner, Hacer
   Demirbas, Berrin
   Acar, Yasar
   Bayram, Murat
TI Relation of resistin levels with C-reactve protein, homocysteine and
   uric acid in smokers and non-smokers
SO JOURNAL OF RESEARCH IN MEDICAL SCIENCES
LA English
DT Article
DE CRP; Homocysteine; Uric Acid; Resistin; Smoking
ID CORONARY-HEART-DISEASE; TYPE-2 DIABETES-MELLITUS; INSULIN-RESISTANCE;
   CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; CIGARETTE-SMOKING; OXIDATIVE
   STRESS; RISK-FACTORS; OBESITY; MEN
AB BACKGROUND: The association between C-reactive protein, homocysteine, uric acid levels and cardiovascular risk have been debated for decades. Resistin is a newly discovered adipocyte derived cytokine. Smoking besides its effect on atherosclerosis, is shown to alter adipocytokine levels. Bearing in mind, these complex relationship of resistin with smoking, C-reactive protein, homocysteine and uric acid, we planned to investigate the association of resistin and these cardiovascular risk factors in smoker and non-smoker subjects.
   METHODS: We conducted a cross-sectional randomized study including 52 smoking and 33 non-smoking men. After making comparisons of C-reactive protein, homocysteine, uric acid and resistin between the two groups, we classified the subjects according to their insulin resistance and body mass and made again the comparisons..
   RESULTS: Resistin levels were higher in smokers than in non-smokers (p<0.001) and also in insulin resistant than in non-insulin resistant smokers (p<0.05). Resistin levels were indifferent in non-smokers as insulin resistance was concerned and in smoker or non-smokers as body mass index was concerned. As all subjects were grouped based on homeostasis model assesment index and body mass index, neither C-reactive protein nor homocysteine and uric acid levels differred.
   CONCLUSIONS: We found that smoking may have influence on resistin levels and in smokers, insulin resistance is related to resistin levels, but in smoker and non-smokers body mass may not have any association with resistin. Resistin also may not have a role in C-reactive protein, homocysteine and uric acid levels both in smokers and non-smokers.
C1 [Esbah, Onur; Gursoy, Gul; Kirnap, Nazli Gulsoy; Cetiner, Hacer; Acar, Yasar; Bayram, Murat] Ankara Educ & Res Hosp, Minist Hlth, Dept Internal Med, Ankara, Turkey.
   [Demirbas, Berrin] MESA Hosp, Dept Endocrinol, Ankara, Turkey.
C3 Ankara Training & Research Hospital; Ministry of Health - Turkey; Mesa
   Hospital
RP Gürsoy, G (corresponding author), Ankara Educ & Res Hosp, Minist Hlth, Dept Internal Med, Ankara, Turkey.
EM gulgursoyyener@yahoo.com
RI gursoy, gul/IZQ-0817-2023
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NR 51
TC 9
Z9 9
U1 0
U2 4
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, 400059, INDIA
SN 1735-1995
EI 1735-7136
J9 J RES MED SCI
JI J. Res. Med. Sci.
PD OCT
PY 2011
VL 16
IS 10
BP 1273
EP 1279
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 843LD
UT WOS:000296672400003
PM 22973320
DA 2025-06-11
ER

PT J
AU Kawamoto, R
   Tabara, Y
   Kohara, K
   Miki, T
   Abe, M
   Kusunoki, T
   Katoh, T
   Ohtsuka, N
AF Kawamoto, Ryuichi
   Tabara, Yasuharu
   Kohara, Katsuhiko
   Miki, Tetsuro
   Abe, Masanori
   Kusunoki, Tomo
   Katoh, Tateaki
   Ohtsuka, Nobuyuki
TI Serum High Molecular Weight Adiponectin is Associated with Mild Renal
   Dysfunction in Japanese Adults
SO JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
LA English
DT Article
DE Adiponectin; eGFR; Renal dysfunction; Japanese adults
ID GLOMERULAR-FILTRATION-RATE; CHRONIC KIDNEY-DISEASE; TYPE-2
   DIABETIC-PATIENTS; INSULIN-RESISTANCE; METABOLIC SYNDROME; RISK-FACTORS;
   CARDIOVASCULAR EVENTS; OXIDATIVE STRESS; PLASMA; MEN
AB Aims: Renal dysfunction is a major public health problem, but there have been few investigations of the relationship between serum high molecular weight (HMW) adiponectin and renal function in Japanese community-dwelling adults.
   Methods: We randomly recruited a sample of 1,849 adult Japanese (793 men aged 60 +/- 14 (mean +/- standard deviation; range, 20-89) years and 1,056 women aged 62 +/- 12 (range, 21-88) years) during their annual health examination in a single community. Participants with an eGFR of >= 60 mL/min/1.73 m(2) were divided into four groups based on quartiles of serum HMW adiponectin levels, and it was investigated whether serum HMW adiponectin is independently associated with eGFR.
   Results: Mean eGFR was significantly higher in the highest quartile than the lowest quartile of serum HMW adiponectin levels. Stepwise multiple linear regression analysis using eGFR as an objective variable, adjusted for confounding factors as explanatory variables, showed that serum HMW adiponectin (beta = 0.068) as well as age (beta = -0.361), prevalence of antihypertensive medication (beta = -0.115), triglycerides (beta = -0.063), low-density lipoprotein cholesterol (beta = -0.094), and fasting plasma glucose (beta = 0.148) were independently associated with eGFR. The multivariate-adjusted odds ratio for mild renal dysfunction of an eGFR <70 mL/min/1.73 m(2) was 0.62 (95% CI, 0.42-0.91) for the highest quartile compared with participants with the lowest serum adiponectin quartile.
   Conclusions: We conclude that a higher serum HMW adiponectin level is associated with a reduced odds ratio of mild renal dysfunction in Japanese adults.
C1 [Kawamoto, Ryuichi; Abe, Masanori; Kusunoki, Tomo] Ehime Univ, Grad Sch Med, Dept Community Med, Seiyo City, Ehime 7971212, Japan.
   [Kawamoto, Ryuichi; Kusunoki, Tomo; Katoh, Tateaki; Ohtsuka, Nobuyuki] Seiyo Municipal Nomura Hosp, Dept Internal Med, Seiyo, Ehime, Japan.
   [Tabara, Yasuharu; Kohara, Katsuhiko; Miki, Tetsuro] Ehime Univ, Grad Sch Med, Dept Geriatr Med, Seiyo City, Ehime 7971212, Japan.
C3 Ehime University; Ehime University
RP Kawamoto, R (corresponding author), Ehime Univ, Grad Sch Med, Dept Community Med, 9-53 Nomura,Nomura Cho, Seiyo City, Ehime 7971212, Japan.
EM rykawamo@yahoo.co.jp
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NR 39
TC 10
Z9 12
U1 0
U2 2
PU JAPAN ATHEROSCLEROSIS SOC
PI TOKYO
PA NICHINAI-KAIKAN B1, 3-28-8 HONGO BUNKYO-KU, TOKYO, 113-0033, JAPAN
SN 1340-3478
EI 1880-3873
J9 J ATHEROSCLER THROMB
JI J. Atheroscler. Thromb.
PY 2010
VL 17
IS 11
BP 1141
EP 1148
DI 10.5551/jat.5124
PG 8
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 690OS
UT WOS:000285014700004
PM 20724800
OA hybrid
DA 2025-06-11
ER

PT J
AU Zhang, XL
   Wei, LQ
   Fu, HJ
   Pan, SF
   Xie, RR
   Yang, JG
AF Zhang, Xue-Lian
   Wei, Li-Qiang
   Fu, Han-Jing
   Pan, Su-Fang
   Xie, Rong-Rong
   Yang, Jin-Gang
TI The Importance of γ-Glutamyltransferase (GGT) Activity: A Potential
   Marker of Left Ventricular (LV) Diastolic Function in Diabetic Patients
   with Cardiovascular Disease
SO ENDOCRINE RESEARCH
LA English
DT Article
DE gamma-Glutamyltransferase (GGT); Diabetes mellitus; Left ventricular
   mass; index; Left ventricular function
ID BLOOD-PRESSURE; METABOLIC SYNDROME; OXIDATIVE STRESS; ATHEROSCLEROSIS;
   PREDICTS; RISK; ASSOCIATION; POPULATION; MELLITUS; ADULTS
AB Objectives. To examine the relation between left ventricular (LV) diastolic function and gamma-glutamyltransferase (GGT) in diabetic individuals with or without previously diagnosed cardiovascular disease. Design. A cross-sectional population-based study. Setting. A university hospital. Subjects. A total of 205 diabetic patients were included in the study. Patients who had cardiovascular disease constituted the study group (CD group; n = 112) and patients who had no complications constituted the control group (ND group; n = 93). Left ventricular diastolic function was assessed by pulsed Doppler tissue imaging and was determined by ratio E wave/A wave. Main outcome measures. GGT levels were higher in CD Group than ND Group (25.9 +/- 2.1 vs. 20.1 +/- 1.5 units/L, p = 0.023). Significant difference between mean diastolic function parameters, such as E wave/A wave (0.86 +/- 0.27 vs. 1.01 +/- 0.36, p = 0.015), of the diabetic patients with and without cardiovascular disease was present. In this study, E wave/A wave correlated with age, waist-to-hip ratio (WHR), systolic blood pressure, and total cholesterol. Negative correlations were also found between LV diastolic function and GGT (beta = -0.009, p = 0.008). Conclusion. The data showed that in type 2 diabetic patients, with evident cardiac disease, metabolic parameters affect diastolic functions more than systolic functions. Besides known cardiovascular disease risk factors, GGT might be an additional marker of diastolic dysfunction in diabetes patients with cardiovascular disease.</.
C1 [Yang, Jin-Gang] Chinese Acad Med Sci, Dept Cardiol, Cardiovasc Inst, Beijing 100037, Peoples R China.
   [Yang, Jin-Gang] Chinese Acad Med Sci, Fuwai Hosp, Beijing 100037, Peoples R China.
   [Yang, Jin-Gang] Peking Union Med Coll, Beijing 100037, Peoples R China.
   [Zhang, Xue-Lian; Wei, Li-Qiang; Fu, Han-Jing; Pan, Su-Fang; Xie, Rong-Rong] Capital Med Univ, Beijing Tongren Hosp, Beijing, Peoples R China.
C3 Chinese Academy of Medical Sciences - Peking Union Medical College;
   Chinese Academy of Medical Sciences - Peking Union Medical College; Fu
   Wai Hospital - CAMS; Chinese Academy of Medical Sciences - Peking Union
   Medical College; Peking Union Medical College; Capital Medical
   University
RP Yang, JG (corresponding author), Chinese Acad Med Sci, Dept Cardiol, Cardiovasc Inst, Beijing 100037, Peoples R China.
EM zhangxl1@trhos.com
RI Wei, Liqiang/R-2408-2019; Zhang, Xue-lian/GNM-6585-2022
FU Beijing Nova program [2006B52]
FX This study was supported by Beijing Nova program (Grant No. 2006B52)
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NR 31
TC 2
Z9 2
U1 1
U2 5
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 0743-5800
EI 1532-4206
J9 ENDOCR RES
JI Endocr. Res.
PY 2010
VL 35
IS 4
BP 155
EP 164
DI 10.3109/07435800.2010.505217
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 666YI
UT WOS:000283158500002
PM 20868287
DA 2025-06-11
ER

PT J
AU Charmandari, E
   Ichijo, T
   Jubiz, W
   Baid, S
   Zachman, K
   Chrousos, GP
   Kino, T
AF Charmandari, Evangelia
   Ichijo, Takamasa
   Jubiz, William
   Baid, Smita
   Zachman, Keith
   Chrousos, George P.
   Kino, Tomoshige
TI A Novel Point Mutation in the Amino Terminal Domain of the Human
   Glucocorticoid Receptor (hGR) Gene Enhancing hGR-Mediated Gene
   Expression
SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Article
ID LIGAND-BINDING DOMAIN; TRANSCRIPTIONAL ACTIVITY; IN-VIVO; RESISTANCE;
   POLYMORPHISM; ASSOCIATION; STRESS; CARBAMAZEPINE; SENSITIVITY; RESPONSES
AB Context: Interindividual variations in glucocorticoid sensitivity have been associated with manifestations of cortisol excess or deficiency and may be partly explained by polymorphisms in the human glucocorticoid receptor (hGR) gene. We studied a 43-yr-old female, who presented with manifestations consistent with tissue-selective glucocorticoid hypersensitivity. We detected a novel, single, heterozygous nucleotide (G -> C) substitution at position 1201 (exon 2) of the hGR gene, which resulted in aspartic acid to histidine substitution at amino acid position 401 in the amino-terminal domain of the hGR alpha. We investigated the molecular mechanisms of action of the natural mutant receptor hGR alpha D401H.
   Methods-Results: Compared with the wild-type hGR alpha, the mutant receptor hGR alpha D401H demonstrated a 2.4-fold increase in its ability to transactivate the glucocorticoid-inducible mouse mammary tumorvirus promoter in response to dexamethasone but had similar affinity for the ligand (dissociation constant = 6.2 +/- 0.6 vs. 6.1 +/- 0.6 nM) and time to nuclear translocation (14.75 +/- 0.25 vs. 14.25 +/- 1.13 min). The mutant receptor hGR alpha D401H did not exert a dominant positive or negative effect upon the wild-type receptor, it preserved its ability to bind to glucocorticoid response elements, and displayed a normal interaction with the glucocorticoid receptor-interacting protein 1 coactivator.
   Conclusions: The mutant receptor hGR alpha D401H enhances the transcriptional activity of glucocorticoid-responsive genes. The presence of the D401H mutation may predispose subjects to obesity, hypertension, and other manifestations of the metabolic syndrome. (J Clin Endocrinol Metab 93: 4963-4968, 2008)
C1 [Charmandari, Evangelia; Chrousos, George P.] Acad Athens, Biomed Res Fdn, Div Endocrinol & Metab, Athens 11527, Greece.
   [Charmandari, Evangelia; Ichijo, Takamasa; Baid, Smita; Zachman, Keith; Chrousos, George P.; Kino, Tomoshige] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Sect Pediat Endocrinol, Program Reprod & Adult Endocrinol, NIH, Bethesda, MD 20892 USA.
   [Jubiz, William] Ctr Endocrinol, Cali, Colombia.
C3 Academy of Athens; National Institutes of Health (NIH) - USA; NIH Eunice
   Kennedy Shriver National Institute of Child Health & Human Development
   (NICHD)
RP Charmandari, E (corresponding author), Acad Athens, Biomed Res Fdn, Div Endocrinol & Metab, 4 Soranou Tou Efessiou St, Athens 11527, Greece.
EM evangelia.charmandari@googlemail.com
RI Chrousos, George/G-8702-2011; Charmandari, Evangelia/AAF-2038-2019
OI Charmandari, Evangelia/0000-0002-0851-6998
FU Eunice Kennedy Shriver National Institute of Child Health and Human
   Development, National Institutes of Health; European Union-European
   Social Fund; Greek Ministry of Development-General Secretariat of
   Research and Technology, Athens, Greece
FX This work was funded by the Intramural Research Program of the Eunice
   Kennedy Shriver National Institute of Child Health and Human
   Development, National Institutes of Health, the European Union-European
   Social Fund, and the Greek Ministry of Development-General Secretariat
   of Research and Technology, Athens, Greece.
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NR 20
TC 51
Z9 56
U1 0
U2 4
PU ENDOCRINE SOC
PI CHEVY CHASE
PA 8401 CONNECTICUT AVE, SUITE 900, CHEVY CHASE, MD 20815-5817 USA
SN 0021-972X
J9 J CLIN ENDOCR METAB
JI J. Clin. Endocrinol. Metab.
PD DEC
PY 2008
VL 93
IS 12
BP 4963
EP 4968
DI 10.1210/jc.2008-0892
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 379LE
UT WOS:000261396900054
PM 18827003
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Haukeland, JW
   Damås, JK
   Konopski, Z
   Loberg, EM
   Haaland, T
   Goverud, I
   Torjesen, PA
   Birkeland, K
   Bjoro, K
   Aukrust, P
AF Haukeland, John Willy
   Damas, Jan Kristian
   Konopski, Zbigniew
   Loberg, Else Marit
   Haaland, Terese
   Goverud, Ingeborg
   Torjesen, Peter A.
   Birkeland, Kare
   Bjoro, Kristian
   Aukrust, Pal
TI Systemic inflammation in nonalcoholic fatty liver disease is
   characterized by elevated levels of CCL2
SO JOURNAL OF HEPATOLOGY
LA English
DT Article
DE adipocytokines; chemokines; cytokines; fatty liver; hepatitis;
   inflammation; nonalcoholic
ID MONOCYTE-CHEMOATTRACTANT PROTEIN-1; NECROSIS-FACTOR-ALPHA; C-REACTIVE
   PROTEIN; INSULIN-RESISTANCE; GENE-EXPRESSION; ADIPOSE-TISSUE;
   TNF-RECEPTORS; STEATOHEPATITIS; CHEMOKINES; ADIPONECTIN
AB Background/Aims: To elucidate the role of systemic inflammation in nonalcoholic fatty liver disease (NAFLD).
   Methods: Serum samples in 47 patients with histologically verified NAFLD (22 with simple steatosis and 25 with nonalcoholic steatohepatitis [NASH]), and in 30 age-, sex- and ethnicity-matched healthy controls, were assessed for (i) general markers of inflammation (C-reactive protein [CRP], tumor necrosis factor [TNF]-alpha, and interleukin [IL]-6), (ii) chemokines (CC-chemokine ligand [CCL] 2/monocyte chemoattractant protein [MCP]-1, CCL19 and CCL21), (iii) adipocytokines related to insulin resistance and inflammation (adiponectin and leptin) and (iv) a marker of oxidative stress (8-isoprostane-F2 alpha).
   Results: Serum levels of several inflammatory cytokines were increased in NAFLD as compared to controls, and IL-6 (P=0.017), CCL2/MCP-1 (P=0.008) and CCL19 (P=0.001), but not CRP (P=0.199), remained elevated also after correction for sex, body mass index (BMI) and age. Comparing NASH with simple steatosis, levels of TNF-alpha (P = 0.024) and CCL2/MCP-1 (P = 0.012) were elevated and adiponectin (in women) (P=0.001) were decreased also after adjustment for sex, BMI and presence of the metabolic syndrome.
   Conclusions: Our results indicate that patients with NAFLD are characterized by a low-grade systemic inflammation. The high CCL2/MCP-1 levels in NASH might be of importance for the conversion from simple steatosis to NASH. (c) 2006 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
C1 Univ Oslo, Fac Div, Aker Univ Hosp, Oslo, Norway.
   Aker Univ Hosp, Dept Gastroenterol, Oslo, Norway.
   Aker Univ Hosp, Hormone Lab, Oslo, Norway.
   Aker Univ Hosp, Dept Endocrinol, Oslo, Norway.
   Univ Oslo, Ulleval Hosp, Dept Pathol, Oslo, Norway.
   Univ Oslo, Rikshosp, Res Inst Internal Med, N-0027 Oslo, Norway.
   Univ Oslo, Rikshosp, Sect Hepatol & Gastroenterol, N-0027 Oslo, Norway.
   Univ Oslo, Rikshosp, Sect Clin Immunol & Infect Dis, Dept Med, N-0027 Oslo, Norway.
C3 University of Oslo; University of Oslo; University of Oslo; University
   of Oslo; University of Oslo; University of Oslo; National Hospital
   Norway; University of Oslo; National Hospital Norway; University of
   Oslo; National Hospital Norway
RP Haukeland, JW (corresponding author), Univ Oslo, Fac Div, Aker Univ Hosp, Oslo, Norway.
EM j.w.haukeland@medisin.uio.no
RI Birkeland, Kåre/E-9750-2010
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NR 39
TC 486
Z9 536
U1 1
U2 35
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0168-8278
EI 1600-0641
J9 J HEPATOL
JI J. Hepatol.
PD JUN
PY 2006
VL 44
IS 6
BP 1167
EP 1174
DI 10.1016/j.jhep.2006.02.011
PG 8
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 048ZF
UT WOS:000237984400020
PM 16618517
DA 2025-06-11
ER

PT J
AU Halperin, RO
   Sesso, HD
   Ma, J
   Buring, JE
   Stampfer, MJ
   Gaziano, JM
AF Halperin, RO
   Sesso, HD
   Ma, J
   Buring, JE
   Stampfer, MJ
   Gaziano, JM
TI Dyslipidemia and the risk of incident hypertension in men
SO HYPERTENSION
LA English
DT Article
DE cholesterol; lipids; hypertension; blood pressure; men; prospective
   studies
ID AT1-TYPE ANGIOTENSIN RECEPTOR; BLOOD-PRESSURE; CHOLESTEROL LEVELS;
   METABOLIC SYNDROME; OXIDATIVE STRESS; FOLLOW-UP; ATHEROGENESIS;
   PREVENTION; COHORT
AB Evidence suggests that hypertension may share a similar pathophysiology with cardiovascular disease (CVD). Thus, dyslipidemia, a strong predictor of CVD, may also predict incident hypertension. We analyzed 3110 men free of hypertension, CVD, and cancer from the Physicians' Health Study, who provided baseline blood samples from which we measured total cholesterol (TC) and HDL cholesterol (HDL-C), and calculated non-HDL-C and the TC/HDL-C ratio. We categorized each lipid parameter into quintiles and considered National Cholesterol Education Project clinical cut points. Other risk factor information was provided from self-reports on the baseline questionnaire. Incident hypertension was defined as either the initiation of antihypertensive treatment, self-reported systolic blood pressure >= 140 mm Hg, or diastolic blood pressure >= 90 mm Hg. Over a mean follow-up of 14.1 years, 1019 men developed hypertension. In Cox proportional hazards models adjusted for lifestyle and clinical risk factors, men in the highest quintile of TC, non-HDL-C, and TC/HDL-C ratio had increased risks of developing hypertension of 23%, 39%, and 54%, respectively, compared with participants in the lowest quintile. Furthermore, men in the highest quintile of HDL-C had a 32% decreased risk of developing hypertension compared with those in the lowest quintile. Models using National Cholesterol Education Project cut points demonstrated similar associations with hypertension. Models excluding men with diabetes and obesity maintained an independent association between baseline lipids and hypertension. These prospective cohort data suggest that dyslipidemias may lead to the subsequent development of hypertension. Thus, plasma lipids may be useful in the identification of men at risk for hypertension.
C1 Brigham & Womens Hosp, Dept Med, Div Prevent Med, Boston, MA 02215 USA.
   Brigham & Womens Hosp, Dept Med, Div Aging, Boston, MA 02215 USA.
   Brigham & Womens Hosp, Dept Med, Channing Lab, Boston, MA 02215 USA.
   Harvard Univ, Sch Med, Boston, MA USA.
   VA Boston Healthcare Syst, Massachusetts Vet Epidemiol Res & Informat Ctr, Boston, MA USA.
   Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.
C3 Harvard University; Harvard University Medical Affiliates; Brigham &
   Women's Hospital; Harvard University; Harvard University Medical
   Affiliates; Brigham & Women's Hospital; Harvard University; Harvard
   University Medical Affiliates; Brigham & Women's Hospital; Harvard
   University; Harvard Medical School; Harvard University; Harvard
   University Medical Affiliates; US Department of Veterans Affairs;
   Veterans Health Administration (VHA); VA Boston Healthcare System;
   Harvard University; Harvard T.H. Chan School of Public Health
RP Brigham & Womens Hosp, Dept Med, Div Prevent Med, 900 Commonwealth Ave E, Boston, MA 02215 USA.
EM hsesso@hsph.harvard.edu
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NR 28
TC 251
Z9 280
U1 1
U2 22
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0194-911X
EI 1524-4563
J9 HYPERTENSION
JI Hypertension
PD JAN
PY 2006
VL 47
IS 1
BP 45
EP 50
DI 10.1161/01.HYP.0000196306.42418.0e
PG 6
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 996BN
UT WOS:000234149500011
PM 16344375
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Pipkin, FB
   Roberts, JM
AF Pipkin, FB
   Roberts, JM
TI Hypertension in pregnancy
SO JOURNAL OF HUMAN HYPERTENSION
LA English
DT Review
DE pregnancy; hypertension; pre-eclampsia; gestational hypertension
ID TUMOR-NECROSIS-FACTOR; HUMAN-ENDOTHELIAL-CELLS; ANGIOTENSIN-II BINDING;
   FREE FATTY-ACIDS; METHYLENETETRAHYDROFOLATE REDUCTASE POLYMORPHISM;
   EXTRACELLULAR FLUID VOLUMES; PREECLAMPTIC WOMEN INCREASE; PLASMA
   CELLULAR FIBRONECTIN; HEALTHY NULLIPAROUS WOMEN; LIPOPROTEIN-LIPASE GENE
AB Hypertension arising during pregnancy remains one of the two most frequently-cited causes of maternal death in the UK. In some cases, pregnancy is unmasking underlying hypertension, which manifests itself in later life. Pregnant women who develop de novo proteinuric hypertension (pre-eclampsia, PE) can share many risk factors with patients with the metabolic syndrome, such as obesity, dyslipidaemia and insulin resistance. However, more than half the women who develop PE remain normotensive thereafter. There is a genetic component(s) to the disease, but it is most improbable that there is a 'PE gene'. Rather, there are factors such as genetically-determined thrombophilias which are predisposers but not prerequisites. Impaired placentation is a feature, with inadequate invasion of the spiral arteries by syncytiotrophoblast and poor remodelling. However, similiar features are found in association with non-hypertensive fetal growth restriction. Prospective studies have suggested a hyperdynamic circulation in early pregnancy, with cardiac output only falling in established disease. Baroreflex sensitivity is decreased in normal pregnancy, and still further decreased in established PE. Activation of endothelial cell function antedates the clinical diagnosis, and has features in common with atherosclerosis. Dyslipidaemia is common in PE and, via oxidation of susceptible lipids, may contribute to endothelial activation. Oxidative 'stress' is increased in PR, perhaps through a variant of the hypoxia-reperfusion phenomenon in the developing intervillous spaces. Such early changes might then lead to the clinically-evident syndrome in susceptible women. PE is a protean, multisystem, multifactorial disease, the causes of which are only slightly less enigmatic than a decade ago.
C1 Univ Nottingham, Sch Human Dev, Nottingham NG7 2RD, England.
C3 University of Nottingham
RP Univ Nottingham Hosp, Dept Obstet & Gynaecol, Nottingham NG7 2UH, England.
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NR 244
TC 40
Z9 41
U1 1
U2 5
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0950-9240
EI 1476-5527
J9 J HUM HYPERTENS
JI J. Hum. Hypertens.
PD OCT-NOV
PY 2000
VL 14
IS 10-11
BP 705
EP 724
DI 10.1038/sj.jhh.1001018
PG 20
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 369ZB
UT WOS:000165096700010
PM 11095161
DA 2025-06-11
ER

PT J
AU Neto, WDP
   de Lucena, TMC
   da Paixao, GA
   Shinohara, NKS
   Pinheiro, AC
   Vicente, AA
   de Souza, RB
   de Morais, MA Jr
AF Neto, Walter de Paula Pinto
   de Lucena, Thays Maria Costa
   da Paixao, Giselle Alves
   Shinohara, Neide Kazue Sakugawa
   Pinheiro, Ana Cristina
   Vicente, Antonio Augusto
   de Souza, Rafael Barros
   de Morais Junior, Marcos Antonio
TI Symbiotic honey beverages: A matrix which tells a story of survival and
   protection of human health from a gastronomic and industrial perspective
SO INTERNATIONAL JOURNAL OF GASTRONOMY AND FOOD SCIENCE
LA English
DT Article
DE Bees; Food matrix; GIT; MetS
ID LACTIC-ACID BACTERIA; FUNCTIONAL FOODS; PROBIOTIC BACTERIA; ENDOTHELIAL
   DYSFUNCTION; QUALITY CHARACTERISTICS; INSULIN-RESISTANCE; METABOLIC
   SYNDROME; HEPATIC STEATOSIS; OXIDATIVE STRESS; GROWTH
AB This review provides an overview of how probiotic honey beverages have been used by humankind throughout history to promote protection of human health. After a brief historical explanation with the main reports involving the use of these beverages for medicinal and conservation purposes, their symbiotic effects and the main physicochemical and microbiological properties reported as benefiting this synergistic effect and also for the control of metabolic syndromes are presented. To this end, the main studies that correlate these inherent properties of the beverages and associate their symbiotic and systemic effects during product storage and when subjected to gastrointestinal conditions are summarized. There is evidence that the physicochemical characteristics of the raw materials used, and especially the properties of the final composition of the beverages, can have positive effects on the health and protection of the host. This observation was possible mainly from experimental studies on prebiotic oligosaccharides, phenolic compounds and short-chain fatty acids. Temperature is highlighted as a crucial extrinsic factor for ensuring the product's viability during storage. The success of these honey-based nutraceutical drinks is due to the close relationship humanity has with honey and its derivatives in different culinary techniques in sweet and Savory preparations, especially when it is culturally wellestablished for having beneficial properties. Additionally, an analysis is conducted on the future scientific and technological research required to further understand these probiotic beverages, particularly for vulnerable groups such as individuals with metabolic diseases and syndromes regarding immune system modulation.
C1 [Neto, Walter de Paula Pinto; da Paixao, Giselle Alves; de Souza, Rafael Barros] Univ Pernambuco, Inst Biol Sci, Campus Recife, BR-50100130 Recife, Brazil.
   [Neto, Walter de Paula Pinto; de Lucena, Thays Maria Costa; da Paixao, Giselle Alves; de Morais Junior, Marcos Antonio] Univ Fed Pernambuco, Ctr Biosci, Dept Genet, Campus Recife, BR-50670901 Recife, Brazil.
   [Shinohara, Neide Kazue Sakugawa] Univ Fed Rural Pernambuco, Dept Rural Technol, Campus Recife, BR-58050900 Recife, Brazil.
   [Pinheiro, Ana Cristina; Vicente, Antonio Augusto] Univ Minho, Ctr Biol Engn, Campus Gualtar, P-4710057 Braga, Portugal.
   [Pinheiro, Ana Cristina; Vicente, Antonio Augusto] LABBELS Associate Lab, Braga Guimaraes, Portugal.
C3 Universidade de Pernambuco (UPE); Universidade Federal de Pernambuco;
   Universidade Federal Rural de Pernambuco (UFRPE); Universidade do Minho
RP de Morais, MA Jr (corresponding author), Univ Fed Pernambuco, Ctr Biociencias, Dept Genet, Ave Moraes Rego 1235,Cidade Univ, BR-50670901 Recife, PE, Brazil.
EM marcos.moraisjr@ufpe.br
RI Barros de Souza, Rafael/CAG-2125-2022; Pinheiro, Ana/AAD-5537-2020;
   Morais, Marcos/B-3363-2013; de Paula Pinto Neto, Walter/HJG-6648-2022;
   Vicente, Antonio/H-1555-2013
OI de Paula Pinto Neto, Walter/0000-0002-4222-7153; Vicente,
   Antonio/0000-0003-3593-8878
FU Fundacao de Amparo a Pesquisa do Estado de Pernambuco (FACEPE); Program
   Arranjos Produtivos Locais (APL); Program Locus de Inovacao February
   2022 [APQ-0161-9.26/22]; FACEPE; Coordenacao de Aperfeicoamento de
   Pessoal de Nivel Superior (CAPES); Portuguese Foundation for Science and
   Technology (FCT) [UIDB/04469/2020]; LABBELS - Associate Laboratory in
   Biotechnology, Bioengineering and Microelectromechanical Systems
   [LA/P/0029/2020]; FCT [2023.06513.CEECIND];  [APQ-0434-2.12/20]
FX This research was funded by Fundacao de Amparo a Pesquisa do Estado de
   Pernambuco (FACEPE) by the Program Arranjos Produtivos Locais (APL)
   grant number APQ-0434-2.12/20 and by the program Locus de Inovacao
   February 2022 grant number APQ-0161-9.26/22. WPPN received a PhD
   scholarship also from FACEPE and Coordenacao de Aperfeicoamento de
   Pessoal de Nivel Superior (CAPES) . This work was also supported by the
   Portuguese Foundation for Science and Technology (FCT) under the scope
   of the strategic funding of UIDB/04469/2020 unit, and by LABBELS -
   Associate Laboratory in Biotechnology, Bioengineering and
   Microelectromechanical Systems, LA/P/0029/2020. ACP acknowledge FCT for
   her Assistant Research contract obtained under the scope of Scientific
   Stimulus Employment with reference 2023.06513.CEECIND.
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NR 144
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1878-450X
EI 1878-4518
J9 INT J GASTRON FOOD S
JI Int. J. Gastron. Food Sci.
PD JUN
PY 2025
VL 40
AR 101183
DI 10.1016/j.ijgfs.2025.101183
PG 12
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA 1RB7H
UT WOS:001471640500001
DA 2025-06-11
ER

PT J
AU Polhemus, D
   Almodiel, D
   Harb, T
   Ziogos, E
   Amat-Codina, N
   Ranek, M
   Santhanam, L
   Gerstenblith, G
   Leucker, TM
AF Polhemus, David
   Almodiel, Diego
   Harb, Tarek
   Ziogos, Efthymios
   Amat-Codina, Nuria
   Ranek, Mark
   Santhanam, Lakshmi
   Gerstenblith, Gary
   Leucker, Thorsten M.
TI Vericiguat prevents high glucose-mediated impaired vascular smooth
   muscle cGMP production and vasorelaxation
SO SCIENTIFIC REPORTS
LA English
DT Article
DE Nitric oxide; cGMP; Vericiguat; Vascular smooth muscle cell function;
   Protein kinase G activity
ID SOLUBLE GUANYLATE-CYCLASE; NITRIC-OXIDE; OXIDATIVE STRESS; INFLAMMATION;
   DYSFUNCTION; INHIBITION
AB Normal endothelial cell dependent vascular smooth muscle cell function is mediated by nitric oxide (NO), which stimulates soluble guanylyl cyclase (sGC) production of the second messenger cyclic guanosine monophosphate (cGMP) leading to increased protein kinase G (PKG) activity and vascular smooth muscle relaxation. NO bioavailability is impaired in high glucose (HG). We tested the hypothesis that the sGC sensitizer vericiguat reverses HG-mediated decreased sGC activity in two experimental models, human aortic vascular smooth muscle cells (HVSMCs) and isolated mouse aortic rings. HVSMCs were exposed to normal glucose (NG) or to HG with or without 1 mu m vericiguat for 24 h and cGMP and PKG activity were measured. Murine aortic rings were incubated in NG or HG for 24 h. Following incubation, the aortic rings were placed in an organ chamber bath containing the same NG or HG concentration used during the incubation. Dose-response curves to increasing concentrations of acetylcholine (ACh) and sodium nitroprusside were constructed for four groups: control (NG), NG + vericiguat, HG, and HG + vericiguat. As compared with the results in the NG group, cGMP production and PKG activity were significantly impaired in the HG cells incubated without, but not in those incubated with, vericiguat. In isolated aortic rings, ACh-mediated relaxation was impaired following treatment with HG, but not when a HG group was treated with vericiguat. The findings suggest clinical studies are warranted to investigate the potential of sGC sensitization as a therapeutic intervention to improve vascular NO-cGMP signaling endothelium -dependent function that is impaired in HG settings such as diabetes and the metabolic syndrome.
C1 [Polhemus, David; Harb, Tarek; Ziogos, Efthymios; Amat-Codina, Nuria; Ranek, Mark; Gerstenblith, Gary; Leucker, Thorsten M.] Johns Hopkins Univ, Dept Med, Div Cardiol, Baltimore, MD 21218 USA.
   [Almodiel, Diego; Santhanam, Lakshmi] Johns Hopkins Univ, Dept Chem & Biomol Engn, Baltimore, MD USA.
   [Santhanam, Lakshmi] Johns Hopkins Univ, Dept Anesthesiol & Crit Care Med, Baltimore, MD USA.
C3 Johns Hopkins University; Johns Hopkins University; Johns Hopkins
   University
RP Leucker, TM (corresponding author), Johns Hopkins Univ, Dept Med, Div Cardiol, Baltimore, MD 21218 USA.
EM tleucke1@jhmi.edu
RI Ranek, Mark/GYA-1420-2022; Leucker, Thorsten/AAW-5971-2020
FU NHLBI; Merck [R01HL148112 01]; NIH
FX This work was funded by Merck, which had no role in the design of the
   study, the collection, management, interpretation of the data, or the
   statistical analysis. The funder reviewed the first submitted version of
   the article but was not involved in the writing or approval of the
   article or the decision to submit the article for publication. This work
   was also supported by the NIH with R01HL148112 01 to Dr. Lakshmi
   Santhanam.
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NR 32
TC 1
Z9 1
U1 2
U2 2
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD FEB 10
PY 2025
VL 15
IS 1
AR 4939
DI 10.1038/s41598-025-88938-w
PG 6
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA W5B3H
UT WOS:001418722300041
PM 39929946
OA gold
DA 2025-06-11
ER

PT J
AU Li, SL
   Chen, FL
   Li, T
   Cheng, YJ
   Huang, GM
   Hou, DQ
   Liu, WQ
   Xu, T
   Liu, JT
AF Li, Shaoli
   Chen, Feilong
   Li, Tao
   Cheng, Yijing
   Huang, Guimin
   Hou, Dongqing
   Liu, Wenqian
   Xu, Tao
   Liu, Junting
TI Higher serum ferritins are associated with higher blood pressure: A
   cross-sectional study
SO MEDICINE
LA English
DT Article
DE adults; hypertension; NHANES; serum ferritin; United States
ID ACUTE-PHASE PROTEINS; METABOLIC SYNDROME; OXIDATIVE STRESS;
   NATIONAL-HEALTH; IRON STATUS; LIFE-STYLE; HYPERTENSION; ADULTS;
   TRANSFERRIN; MECHANISMS
AB The aim of the study was to investigate the association between serum ferritin and hypertension among American adults from National Health and Nutrition Examination Survey (NHANES) 1999 to 2018. A total of 16,125 participants were included. Weighted logistic regression and subgroup analyses were performed to explore the association. We found that serum ferritin was closely correlated to hypertension. Individuals with high serum ferritin were more likely to have higher systolic or diastolic blood pressure (SBP, DBP) than those with lower serum ferritin. Restricted cubic spline showed a significant non-linear association between serum ferritin and SBP/DBP. Higher level of serum ferritin (Q3 74.1-147 mu g/L and Q4 > 147 mu g/L) was found to have positive association with high SBP [Q3 (OR: 1.246, 95% CI:1.020-1.523), Q4 (OR: 1.354, 95% CI:1.096-1.674)], and hypertension [Q3 (OR: 1.283, 95% CI:1.099-1.499), Q4 (OR: 1.424, 95% CI:1.197-1.63)] in the whole population. In people aged between 20 and 60, subjects with high serum ferritin were significantly associated with a higher risk of hypertension, but in those over 60, the relationship between serum ferritin level and hypertension is negative. A non-linear association between serum ferritin and SBP, as well as DBP, was discovered. There was age difference in association between serum ferritin and hypertension in American adults, and further researches were needed to understand the mechanisms behind the difference.
C1 [Li, Shaoli; Li, Tao; Cheng, Yijing; Huang, Guimin; Hou, Dongqing; Liu, Wenqian; Liu, Junting] Capital Inst Pediat, Child Hlth Big Data Res Ctr, Beijing, Peoples R China.
   [Chen, Feilong; Xu, Tao] Chinese Acad Med Sci, Inst Basic Med Sci, Dept Epidemiol & Stat, Beijing, Peoples R China.
   [Chen, Feilong; Xu, Tao] Peking Union Med Coll, Sch Basic Med, Beijing, Peoples R China.
   [Liu, Junting] Chinese Acad Med Sci, Inst Basic Med Sci, Dept Epidemiol & Stat, 5 Dong Dan San Tiao, Beijing 100005, Peoples R China.
   [Liu, Junting] Peking Union Med Coll, Sch Basic Med, 5 Dong Dan San Tiao, Beijing 100005, Peoples R China.
C3 Capital Institute of Pediatrics (CIP); Institute of Basic Medical
   Sciences - CAMS; Chinese Academy of Medical Sciences - Peking Union
   Medical College; Chinese Academy of Medical Sciences - Peking Union
   Medical College; Peking Union Medical College; Chinese Academy of
   Medical Sciences - Peking Union Medical College; Institute of Basic
   Medical Sciences - CAMS; Chinese Academy of Medical Sciences - Peking
   Union Medical College; Peking Union Medical College
RP Liu, JT (corresponding author), Chinese Acad Med Sci, Inst Basic Med Sci, Dept Epidemiol & Stat, 5 Dong Dan San Tiao, Beijing 100005, Peoples R China.; Liu, JT (corresponding author), Peking Union Med Coll, Sch Basic Med, 5 Dong Dan San Tiao, Beijing 100005, Peoples R China.
EM socott@126.com; feilong_chen@ibms.pumc.edu.cn; xutaosd@126.com;
   yijing_cheng@163.com; Guiminhuang@163.com; dqhou@sina.com;
   junting_liu@163.com; xutaosd@126.com; Junting_liu@163.com
RI Liu, Wenqian/GXH-6534-2022
OI Chen, Feilong/0000-0002-7030-8268
FU National Natural Science Foundation [32070188]; Research Foundation of
   Capital Institute of Pediatrics [ERB-2023-01]; Public service
   development and reform pilot project of Beijing Medical Research
   Institute [BMR2021-3]
FX This study was supported by the National Natural Science Foundation
   (32070188), Research Foundation of Capital Institute of Pediatrics
   (ERB-2023-01), and Public service development and reform pilot project
   of Beijing Medical Research Institute (BMR2021-3). The funders had no
   role in the study design, data collection and interpretation or the
   decision to submit the work for publication.
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NR 54
TC 2
Z9 2
U1 0
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD MAR 22
PY 2024
VL 103
IS 12
AR e37485
DI 10.1097/MD.0000000000037485
PG 10
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA MW6J1
UT WOS:001196708800036
PM 38518010
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Ma, YN
   Jiang, XM
   Tang, W
   Song, PP
AF Ma, Ya-Nan
   Jiang, Xuemei
   Tang, Wei
   Song, Peipei
TI Influence of intermittent fasting on autophagy in the liver
SO BIOSCIENCE TRENDS
LA English
DT Review
DE metabolism; diet; nutrient; NAFLD; HCC; liver disease
ID CHAPERONE-MEDIATED AUTOPHAGY; HEPATIC GLUCOSE-PRODUCTION;
   GROWTH-HORMONE; CONSTITUTIVE AUTOPHAGY; BODY-COMPOSITION; STARVATION;
   METABOLISM; INSULIN; ACTIVATION; WEIGHT
AB Studies have found that intermittent fasting (IF) can prevent diabetes, cancer, heart disease, and neuropathy, while in humans it has helped to alleviate metabolic syndrome, asthma, rheumatoid arthritis, Alzheimer's disease, and many other disorders. IF involves a series of coordinated metabolic and hormonal changes to maintain the organism's metabolic balance and cellular homeostasis. More importantly, IF can activate hepatic autophagy, which is important for maintaining cellular homeostasis and energy balance, quality control, cell and tissue remodeling, and defense against extracellular damage and pathogens. IF affects hepatic autophagy through multiple interacting pathways and molecular mechanisms, including adenosine monophosphate (AMP)-activated protein kinase (AMPK), mammalian target of rapamycin (mTOR), silent mating-type information regulatory 2 homolog-1 (SIRT1), peroxisomal proliferator-activated receptor alpha (PPAR alpha) and farnesoid X receptor (FXR), as well as signaling pathways and molecular mechanisms such as glucagon and fibroblast growth factor 21 (FGF21). These pathways can stimulate the pro-inflammatory cytokines interleukin 6 (IL6) and tumor necrosis factor alpha (TNF-alpha), play a cytoprotective role, downregulate the expression of aging-related molecules, and prevent the development of steatosis-associated liver tumors. By influencing the metabolism of energy and oxygen radicals as well as cellular stress response systems, IF protects hepatocytes from genetic and environmental factors. By activating hepatic autophagy, IF has a potential role in treating a variety of liver diseases, including non-alcoholic fatty liver disease, drug-induced liver injury, viral hepatitis, hepatic fibrosis, and hepatocellular carcinoma. A better understanding of the effects of IF on liver autophagy may lead to new approaches for the prevention and treatment of liver disease.
C1 [Ma, Ya-Nan; Jiang, Xuemei] Hainan Med Univ, Hainan Affiliated Hosp, Hainan Gen Hosp, Dept Gastroenterol, 19 Xiuhua Rd, Haikou 570100, Hainan, Peoples R China.
   [Ma, Ya-Nan; Song, Peipei] Natl Ctr Global Hlth & Med, Ctr Clin Sci, 1-21-1 Toyama,Shinjuku Ku, Tokyo 1628655, Japan.
   [Tang, Wei] Natl Ctr Global Hlth & Med, Int Hlth Care Ctr, Tokyo, Japan.
   [Tang, Wei] Univ Tokyo Hosp, Dept Surg, Hepatobiliary Pancreat Surg Div, Tokyo, Japan.
C3 Hainan Medical University; Japan Institute for Health Security (JIHS);
   National Center for Global Health & Medicine - Japan; Japan Institute
   for Health Security (JIHS); National Center for Global Health & Medicine
   - Japan; University of Tokyo
RP Jiang, XM (corresponding author), Hainan Med Univ, Hainan Affiliated Hosp, Hainan Gen Hosp, Dept Gastroenterol, 19 Xiuhua Rd, Haikou 570100, Hainan, Peoples R China.; Song, PP (corresponding author), Natl Ctr Global Hlth & Med, Ctr Clin Sci, 1-21-1 Toyama,Shinjuku Ku, Tokyo 1628655, Japan.
EM jiangxuemei@hainmc.edu.cn; psong@it.ncgm.go.jp
FU National Natural Science Foundation of China [81960446]; 2023 Foreign
   Experts Program in Hainan Province [SQ2023WGZJ0002]
FX This work was supported by a grant from the National Natural Science
   Foundation of China (No. 81960446) and the 2023 Foreign Experts Program
   in Hainan Province (SQ2023WGZJ0002).
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NR 165
TC 14
Z9 14
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PU IRCA-BSSA
PI TOKYO
PA PEARL CITY KOISHIKAWA 603, 2-4-5 KASUGA, BUNKYO-KU, TOKYO, 112-0003,
   JAPAN
SN 1881-7815
EI 1881-7823
J9 BIOSCI TRENDS
JI BioSci. Trends
PD OCT
PY 2023
VL 17
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EP 355
DI 10.5582/bst.2023.01207
EA SEP 2023
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WC Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics
GA GB6Y7
UT WOS:001061682500001
PM 37661370
OA gold
DA 2025-06-11
ER

PT J
AU Omar, N
   Yeoh, BS
   Chellappan, K
   Chui, SZ
   Salamt, N
   Aminuddin, A
AF Omar, Norsuhana
   Yeoh, Boon Seng
   Chellappan, Kalaivani
   Chui, Sara Zijiun
   Salamt, Norizam
   Aminuddin, Amilia
TI The effects of pedometer-based exercise on central and peripheral
   vascular functions among young sedentary men with CVD risk factors
SO FRONTIERS IN PHYSIOLOGY
LA English
DT Article
DE exercise; finger photoplethysmography; pedometer; cardiovascular; pulse
   wave velocity; augmentation index
ID PULSE-WAVE-VELOCITY; PHOTOPLETHYSMOGRAPHY FITNESS INDEX; CARDIOVASCULAR
   RISK; AEROBIC EXERCISE; ARTERIAL STIFFNESS; METABOLIC SYNDROME;
   DIABETES-MELLITUS; PHYSICAL-ACTIVITY; OXIDATIVE STRESS; WOMEN
AB Introduction: Cardiovascular diseases (CVDs) remain the main cause of morbidity and mortality in Malaysia and worldwide. This is mainly due to an increase in the prevalence of CVD risk factors such as hypertension, dyslipidemia, smoking, and obesity. Increased physical activity has been recommended as a modality to improve CVD risk. Pulse wave velocity (PWVCF), augmentation index (AI), and finger photoplethysmography fitness (PPGF) index have been introduced to assess the vascular functions related to CVD risk factors. The effects of long-term exercise on PPGF index are not established.
   Materials and Methods: A total of 70 young men who were sedentary with two or more cardiovascular risk factors were recruited. Subjects were randomly assigned to a control group (CG) (n = 34; no change in walking) and pedometer group (PG) (n = 36; minimum target: 8,000 steps/day). PWVCF and AI were measured via the Vicorder system. The PPGF index was obtained via the finger photoplethysmography method. All parameters were measured at baseline and after 6 and 12 weeks.
   Results: After intervention, the PG had significant increased step count from 4,996 +/- 805 to 10,128 +/- 511 steps/day (p < 0.001). The PG showed significant improvement in anthropometric variables, lipid, PWVCF, AI, and PPGF index (time and group effect p < 0.001). No changes were observed in CG.
   Conclusion: This signifies that pedometer-based walking program is beneficial in improving markers of vascular functions among young working sedentary men with CVD risk factors. Pedometer-based exercise should be encouraged to improve cardiovascular health.
C1 [Omar, Norsuhana; Yeoh, Boon Seng] Univ Sains Malaysia, Sch Med Sci, Dept Physiol, George Town, Kelantan, Malaysia.
   [Chellappan, Kalaivani] Univ Kebangsaan Malaysia, Fac Engn & Built Environm, Dept Elect Elect & Syst Engn, Bangi, Selangor, Malaysia.
   [Chui, Sara Zijiun; Salamt, Norizam; Aminuddin, Amilia] Univ Kebangsaan Malaysia, Fac Med, Med Ctr, Dept Physiol, Kuala Lumpur, Malaysia.
C3 Universiti Sains Malaysia; Universiti Kebangsaan Malaysia; Universiti
   Kebangsaan Malaysia
RP Aminuddin, A (corresponding author), Univ Kebangsaan Malaysia, Fac Med, Med Ctr, Dept Physiol, Kuala Lumpur, Malaysia.
EM amilia@ppukm.ukm.edu.my
RI Chellappan, Kalaivani/L-1192-2014; Aminuddin, Amilia/AAC-5414-2020
OI Aminuddin, Amilia/0000-0002-1329-0444
FU Ministry of Higher Education under KTP grants (PHUM-2013)
FX The authors would like to thank Siao Suan Cheong for technical support.
   The project was funded by the Ministry of Higher Education under KTP
   grants (PHUM-2013).
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SC Physiology
GA D4XC0
UT WOS:000968769600001
PM 37057183
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Hegde, M
   Girisa, S
   BharathwajChetty, B
   Vishwa, R
   Kunnumakkara, AB
AF Hegde, Mangala
   Girisa, Sosmitha
   BharathwajChetty, Bandari
   Vishwa, Ravichandran
   Kunnumakkara, Ajaikumar B.
TI Curcumin Formulations for Better Bioavailability: What We Learned from
   Clinical Trials Thus Far?
SO ACS OMEGA
LA English
DT Article
ID QUALITY-OF-LIFE; TYPE-2 DIABETES-MELLITUS; FATTY LIVER-DISEASE; CHRONIC
   PULMONARY COMPLICATIONS; RHEUMATOID-ARTHRITIS PATIENTS;
   OXIDANT-ANTIOXIDANT BALANCE; RANDOMIZED CONTROLLED-TRIAL; SYSTEMIC
   OXIDATIVE STRESS; SOLID LIPID CURCUMIN; DOUBLE-BLIND
AB Curcumin has been credited with a wide spectrum of pharmacological properties for the prevention and treatment of several chronic diseases such as arthritis, autoimmune diseases, cancer, cardiovascular diseases, diabetes, hemoglobinopathies, hypertension, infectious diseases, inflammation, metabolic syndrome, neurological diseases, obesity, and skin diseases. However, due to its weak solubility and bioavailability, it has limited potential as an oral medication. Numerous factors including low water solubility, poor intestinal permeability, instability at alkaline pH, and fast metabolism contribute to curcumin's limited oral bioavailability. In order to improve its oral bioavailability, different formulation techniques such as coadministration with piperine, incorporation into micelles, micro/nanoemulsions, nanoparticles, liposomes, solid dispersions, spray drying, and noncovalent complex formation with galactomannosides have been investigated with in vitro cell culture models, in vivo animal models, and humans. In the current study, we extensively reviewed clinical trials on various generations of curcumin formulations and their safety and efficacy in the treatment of many diseases. We also summarized the dose, duration, and mechanism of action of these formulations. We have also critically reviewed the advantages and limitations of each of these formulations compared to various placebo and/or available standard care therapies for these ailments. The highlighted integrative concept embodied in the development of next-generation formulations helps to minimize bioavailability and safety issues with least or no adverse side effects and the provisional new dimensions presented in this direction may add value in the prevention and cure of complex chronic diseases.
C1 [Hegde, Mangala; Girisa, Sosmitha; BharathwajChetty, Bandari; Vishwa, Ravichandran; Kunnumakkara, Ajaikumar B.] Indian Inst Technol Guwahati, Dept Biosci & Bioengn, Gauhati 781039, Assam, India.
C3 Indian Institute of Technology System (IIT System); Indian Institute of
   Technology (IIT) - Guwahati
RP Kunnumakkara, AB (corresponding author), Indian Inst Technol Guwahati, Dept Biosci & Bioengn, Gauhati 781039, Assam, India.
EM kunnumakkara@iitg.ac.in
RI Kunnumakkara, Ajaikumar/AAH-5214-2019; Girisa, Sosmitha/JGD-3270-2023;
   Kunnumakkara, Ajaikumar/H-8566-2012
OI Kunnumakkara, Ajaikumar/0000-0001-9121-6816; BharathwajChetty,
   Bandari/0000-0002-4147-3993; Vishwa, Ravichandran/0000-0001-5532-1387
FU Department of Biotechnology (DBT) , Government of India
   [BT/556/NE/U-Excel/2016]
FX Funding This project was supported by BT/556/NE/U-Excel/2016 grant
   awarded to A.B.K. by Department of Biotechnology (DBT) , Government of
   India.
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NR 314
TC 97
Z9 99
U1 8
U2 55
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 2470-1343
J9 ACS OMEGA
JI ACS Omega
PD MAR 28
PY 2023
VL 8
IS 12
BP 10713
EP 10746
DI 10.1021/acsomega.2c07326
EA MAR 2023
PG 34
WC Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry
GA A5GQ2
UT WOS:000950581800001
PM 37008131
OA Green Published, gold
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Gutiérrez-Lara, EJ
   Sánchez-López, A
   Murbartián, J
   Acosta-Cota, SJ
   Centurión, D
AF Gutierrez-Lara, Erika J.
   Sanchez-Lopez, Araceli
   Murbartian, Janet
   Acosta-Cota, Selene J.
   Centurion, David
TI Effect of chronic administration of 17β-estradiol on the vasopressor
   responses induced by the sympathetic nervous system in insulin
   resistance rats
SO STEROIDS
LA English
DT Article
DE 17?-estradiol; Insulin resistance; Hyperinsulinemia; Hypertension;
   Vasopressor response
ID BLOOD-PRESSURE REGULATION; OXIDATIVE STRESS; FRUCTOSE; ESTROGEN;
   ASSOCIATION; DECREASES; ESTRADIOL
AB Several studies have demonstrated that the underlying mechanism of insulin resistance (IR) is linked with developing diseases like diabetes mellitus, hypertension, metabolic syndrome, and polycystic ovary syndrome. In turn, the dysfunction of female gonadal hormones (especially 17 beta-estradiol) may be related to the development of IR complications since different studies have shown that 17 beta-estradiol has a cardioprotector and vasorelaxant effect. This study aimed was to determine the effect of the 17 beta-estradiol administration in insulin-resistant rats and its effects on cardiovascular responses in pithed rats. Thus, the vasopressor responses are induced by sym-pathetic stimulation or i.v. bolus injections of noradrenaline (alpha 1/2), methoxamine (alpha 1), and UK 14,304 (alpha 2) adrenergic agonist were determined in female pithed rats with fructose-induced insulin resistance or control rats treated with: 1) 17 beta-estradiol or 2) its vehicle (oil) for 5 weeks. Thus, 17 beta-estradiol decreased heart rate, pre-vented the increase of blood pressure induced by ovariectomy, but with the opposite effect on sham-operated rats; and decreased vasopressor responses induced by i.v. bolus injections of noradrenaline on sham-operated (control and fructose group) and ovariectomized (control) rats, and those induced by i.v. bolus injections of methoxamine (alpha 1 adrenergic agonist). Overall, these results suggest 17 beta-estradiol has a cardioprotective effect, and its effect on vasopressor responses could be mediated mainly by the alpha 1 adrenergic receptor. In contrast, IR with ovariectomy 17 beta-estradiol decreases or loses its cardioprotector effect, this could suggest a possible link between the adrenergic receptors and the insulin pathway.
C1 [Gutierrez-Lara, Erika J.; Sanchez-Lopez, Araceli; Murbartian, Janet; Centurion, David] Cinvestav Unidad Coapa, Dept Farmacobiol, Czda Tenorios 235, Mexico City 14330, DF, Mexico.
   [Acosta-Cota, Selene J.] Univ Autonoma Occidente, Dept Ciencias Salud, Blvd Lola Beltran & Blvd Rolando Arjona S-N, Culiacan 80020, Sinaloa, Mexico.
RP Centurión, D (corresponding author), Cinvestav Unidad Coapa, Dept Farmacobiol, Czda Tenorios 235, Mexico City 14330, DF, Mexico.
RI Centurion, David/A-4507-2008
OI Gutierrez-Lara, Erika J/0000-0003-1780-7487; Murbartian,
   Janet/0000-0001-5776-1167; Acosta-Cota, Selene J/0000-0003-4923-6105
FU CONACyT (Mexico);  [252702]
FX Acknowledgments The authors thank CONACyT (Mexico) for their financial
   support (Grant No. 252702) .
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NR 53
TC 4
Z9 4
U1 0
U2 6
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0039-128X
EI 1878-5867
J9 STEROIDS
JI Steroids
PD DEC
PY 2022
VL 188
AR 109132
DI 10.1016/j.steroids.2022.109132
EA NOV 2022
PG 12
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 7B9JW
UT WOS:000899442300002
PM 36273542
DA 2025-06-11
ER

PT J
AU Shinlapawittayatorn, K
   Pongkan, W
   Sivasinprasasn, S
   Chattipakorn, SC
   Chattipakorn, N
AF Shinlapawittayatorn, Krekwit
   Pongkan, Wanpitak
   Sivasinprasasn, Sivaporn
   Chattipakorn, Siriporn C.
   Chattipakorn, Nipon
TI Sexual dimorphism in cardiometabolic and cardiac mitochondrial function
   in obese rats following sex hormone deprivation
SO NUTRITION & DIABETES
LA English
DT Article
ID IMPAIRED GLUCOSE-TOLERANCE; ADIPOSE-SPECIFIC PROTEIN;
   HEART-RATE-VARIABILITY; INSULIN-RESISTANCE; GENDER-DIFFERENCES;
   METABOLIC SYNDROME; OXIDATIVE STRESS; SENSITIVITY; PLASMA; MODEL
AB Objective Our study aims to test the hypothesis that poorer function of cardiac mitochondria in males, under sex hormone-deprived and obese-insulin-resistant conditions, is responsible for a worse cardiometabolic function than females. Methods One hundred and forty-four rats were subjected to receive either 12 weeks of normal diet (ND) or a high-fat diet (HFD) consumption following the induction of sex hormone deprivation. Temporal evaluations of metabolic parameters, cardiac autonomic modulation, left ventricular (LV) contractile, and mitochondrial functions were measured after starting each feeding protocol for 4, 8, and 12 weeks. Results After HFD feeding for 8 weeks, increased plasma insulin and HOMA index were initially observed in male HFD-fed sham-operated rats (M-HFS), male HFD-fed orchiectomized rats (M-HFO), female ND-fed ovariectomized rats (F-OVX), female HFD-fed sham-operated rats (F-HFS), and female HFD-fed ovariectomized rats (F-HFO) groups. In addition, as early as week 4, male ND-fed orchiectomized rats (M-ORX) and M-HFO exhibited impaired cardiac autonomic balance, LV contractile and mitochondrial functions, whereas M-HFS and F-HFO developed these impairments at week 8 and F-OVX and F-HFS exhibited them at week 12. Conclusion We concluded that sex hormone-deprived females are prone to develop metabolic impairments, whereas males are more likely to have cardiac autonomic impairment, LV contractile and mitochondrial dysfunction even in the absence of obese-insulin-resistant condition. However, under estrogen-deprived condition, these impairments were further accelerated and aggravated by obese-insulin resistance.
C1 [Shinlapawittayatorn, Krekwit; Pongkan, Wanpitak; Sivasinprasasn, Sivaporn; Chattipakorn, Siriporn C.; Chattipakorn, Nipon] Chiang Mai Univ, Fac Med, Cardiac Electrophysiol Res & Training Ctr, Chiang Mai 50200, Thailand.
   [Shinlapawittayatorn, Krekwit; Chattipakorn, Nipon] Chiang Mai Univ, Fac Med, Dept Physiol, Cardiac Electrophysiol Unit, Chiang Mai 50200, Thailand.
   [Shinlapawittayatorn, Krekwit; Chattipakorn, Siriporn C.; Chattipakorn, Nipon] Chiang Mai Univ, Ctr Excellence Cardiac Electrophysiol Res, Chiang Mai 50200, Thailand.
   [Pongkan, Wanpitak] Chiang Mai Univ, Fac Vet Med, Dept Vet Biosci & Vet Publ Hlth, Chiang Mai 50200, Thailand.
   [Sivasinprasasn, Sivaporn] Mae Fah Luang Univ, Sch Med, Chiang Rai 57100, Thailand.
   [Chattipakorn, Siriporn C.] Chiang Mai Univ, Fac Dent, Dept Oral Biol & Diagnost Sci, Chiang Mai 50200, Thailand.
C3 Chiang Mai University; Chiang Mai University; Chiang Mai University;
   Chiang Mai University; Mae Fah Luang University; Chiang Mai University
RP Chattipakorn, N (corresponding author), Chiang Mai Univ, Fac Med, Cardiac Electrophysiol Res & Training Ctr, Chiang Mai 50200, Thailand.; Chattipakorn, N (corresponding author), Chiang Mai Univ, Fac Med, Dept Physiol, Cardiac Electrophysiol Unit, Chiang Mai 50200, Thailand.; Chattipakorn, N (corresponding author), Chiang Mai Univ, Ctr Excellence Cardiac Electrophysiol Res, Chiang Mai 50200, Thailand.
EM nchattip@gmail.com
RI Chattipakorn, Nipon/AAJ-4049-2021; Pongkan, Wanpitak/N-8420-2018;
   Shinlapawittayatorn, Krekwit/AAW-2698-2021
OI Chattipakorn, Nipon/0000-0003-3026-718X; Chattipakorn,
   Siriporn/0000-0003-1677-7052
FU National Research Council of Thailand [2563NRCT321511]; Thailand Science
   Research and Innovation-Fundamental Fund-Chiang Mai University; National
   Research Council of Thailand; NSTDA Research Chair grant from the
   National Science and Technology Development Agency Thailand; Chiang Mai
   University Endowment Fund; Chiang Mai University Center of Excellence
   Award
FX This work was supported by the National Research Council of Thailand
   grant 2563NRCT321511 (KS), Thailand Science Research and
   Innovation-Fundamental Fund-Chiang Mai University (KS), Senior Research
   Scholar grant from the National Research Council of Thailand (SCC), the
   NSTDA Research Chair grant from the National Science and Technology
   Development Agency Thailand (NC), Chiang Mai University Endowment Fund
   (KS), and the Chiang Mai University Center of Excellence Award (NC).
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NR 43
TC 10
Z9 10
U1 0
U2 2
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 2044-4052
J9 NUTR DIABETES
JI Nutr. Diabetes
PD MAR 17
PY 2022
VL 12
IS 1
AR 11
DI 10.1038/s41387-022-00189-0
PG 9
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA ZV1QR
UT WOS:000770310300001
PM 35301277
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Santa, K
AF Santa, Kazuki
TI Grape Phytochemicals and Vitamin D in the Alleviation of Lung Disorders
SO ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS
LA English
DT Review
DE Vitamin D; phytochemicals; COVID-19; pneumonia; asthma; sleep apnea
   syndrome (SA); interstitial pneumonia (IP); lung cancer; chronic
   obstructive pulmonary disease (COPD); TNF-alpha
ID INFLAMMATORY-BOWEL-DISEASE; SLEEP-APNEA SYNDROME; OXIDATIVE STRESS;
   PULMONARY-FIBROSIS; SEED EXTRACT; TNF-ALPHA; TGF-BETA; SARS-COV-2
   INFECTION; ACQUIRED PNEUMONIA; PHENOLIC-COMPOUNDS
AB Background: Typical lung diseases are pneumonia, asthma, sleep apnea syndrome (SA), interstitial pneumonia (IP), lung cancer, and chronic obstructive pulmonary disease (COPD). Coronavirus disease 2019 (COVID-19) is a type of viral pneumonia. Many researchers have reported that phytochemicals (chemical compounds produced by plants) and vitamin D are useful in stimulating our immunity. This review discusses the alleviation of lung diseases by grape phytochemicals and vitamin D. Discussion: Pneumonia is an acute inflammation caused by the infection of pathogens; the worst case is a fatal cytokine storm in the lung. In asthma, allergens, tobacco smoke, or air pollution may cause seizures. Lung diseases caused by lung fibrosis may manifest chronic inflammation, progress into alveolar fibrosis, and cause respiratory malfunction. SA is a lifestyle disease related to obesity and metabolic syndrome. To alleviate these symptoms, changing the eating habit is one of the strategies. Improvement in the daily lifestyle reduces the risk of lung cancer. Self-management, including nutritional management and exercise, is very important for COPD patients in addition to pharmacotherapy. Conclusion: The intake of grape phytochemicals and vitamin D prevents the progress of lung diseases. Both phytochemicals and vitamin D prevent the production of proinflammatory cytokine, TNF-alpha, that is responsible for inflammation and lung diseases. Daily intake of grape phytochemicals is important. The optimum vitamin D level in serum is > 30 ng/mL. For the prevention of lung diseases, up-regulating immunity and maintaining good gut microbiota are important because gut microbiota change depending on what we eat.
C1 [Santa, Kazuki] Tokyo Coll Biotechnol, Dept Biotechnol, Ota Ku, Tokyo, Japan.
RP Santa, K (corresponding author), Tokyo Coll Biotechnol, Dept Biotechnol, Ota Ku, Tokyo, Japan.
EM kazuki_santa@hotmail.com
RI Santa, Kazuki/Y-6204-2019
OI Santa, Kazuki/0000-0003-2066-1407
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NR 190
TC 7
Z9 7
U1 2
U2 14
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1871-5303
EI 2212-3873
J9 ENDOCR METAB IMMUNE
JI Endocr. Metab. Immune Disord.-Drug Targets
PY 2022
VL 22
IS 13
BP 1276
EP 1292
DI 10.2174/1871530322666220407002936
PG 17
WC Endocrinology & Metabolism; Immunology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Immunology; Pharmacology & Pharmacy
GA 7A9MU
UT WOS:000898771900006
PM 35388768
DA 2025-06-11
ER

PT J
AU Yue, L
   Jiang, N
   Wu, AG
   Qiu, WQ
   Shen, X
   Qin, DL
   Li, H
   Lin, J
   Liang, SC
   Wu, JM
AF Yue, Liang
   Jiang, Nan
   Wu, Anguo
   Qiu, Wenqiao
   Shen, Xin
   Qin, Dalian
   Li, Hong
   Lin, Jing
   Liang, Sicheng
   Wu, Jianming
TI Plumbagin can potently enhance the activity of xanthine oxidase: in
   vitro, in vivo and in silico studies
SO BMC PHARMACOLOGY & TOXICOLOGY
LA English
DT Article
DE Xanthine oxidase; Plumbagin; Uric acid; Enzymatic reaction kinetics;
   Toxic metabolism
ID OXIDOREDUCTASE; METABOLISM
AB Background Abnormally elevated xanthine oxidase (XO) activity has been verified to cause various pathological processes, such as gout, oxidative stress injury and metabolic syndrome. Thus, XO activators may exhibit above potential toxicological properties. Plumbagin (PLB) is an important active compound in traditional Chinese medicine (TCM), while its obvious toxic effects have been reported, including diarrhea, skin rashes and hepatic toxicity. However, the potential toxicity associated with enhancement of XO activity has not been fully illuminated so far. Methods The present study investigated the effect of PLB on XO activity by culturing mouse liver S9 (MLS9), human liver S9 (HLS9), XO monoenzyme system with PLB and xanthine. Then, the molecular docking and biolayer interferometry analysis were adopted to study the binding properties between PLB and XO. Finally, the in vivo acceleration effect also investigated by injected intraperitoneally PLB to KM mice for 3 days. Results PLB could obviously accelerate xanthine oxidation in the above three incubation systems. Both the V-max values and intrinsic clearance values (CLint, V-max/K-m) of XO in the three incubation systems increased along with elevated PLB concentration. In addition, the molecular docking study and label-free biolayer interferometry assay displayed that PLB was well bound to XO. In addition, the in vivo results showed that PLB (2 and 10 mg/kg) significantly increased serum uric acid levels and enhanced serum XO activity in mice. Conclusion In summary, this study outlines a potential source of toxicity for PLB due to the powerful enhancement of XO activity, which may provide the crucial reminding for the PLB-containing preparation development and clinical application.
C1 [Yue, Liang; Jiang, Nan; Wu, Anguo; Qiu, Wenqiao; Shen, Xin; Qin, Dalian; Li, Hong; Lin, Jing; Liang, Sicheng; Wu, Jianming] Southwest Med Univ, Sch Pharm, Dept Pharmacol, Luzhou 646000, Sichuan, Peoples R China.
   [Wu, Anguo; Qin, Dalian; Wu, Jianming] Inst Cardiovasc Res, Med Key Lab Drug Discovery & Druggabil Evaluat Si, Luzhou Key Lab Act Screening & Druggabil Evaluat, Key Lab Med Electrophysiol,Minist Educ China, Luzhou 646000, Sichuan, Peoples R China.
   [Liang, Sicheng] Southwest Med Univ, Dept Gastroenterol, Affiliated Hosp, Luzhou 646000, Sichuan, Peoples R China.
C3 Southwest Medical University; Ministry of Education - China; Southwest
   Medical University
RP Liang, SC; Wu, JM (corresponding author), Southwest Med Univ, Sch Pharm, Dept Pharmacol, Luzhou 646000, Sichuan, Peoples R China.
EM liangpharm@163.com; jianmingwu@swmu.edu.cn
RI liang, sicheng/LCD-1645-2024; Anguo, Wu/GRF-4136-2022; qiu,
   wenqiao/LEL-9490-2024; Wu, Jianming/B-6839-2018
OI Wu, Jianming/0000-0002-6136-7469; Wu, An-Guo/0000-0002-9850-7576
FU National Key Research and Development Program of China
   [2018ZX09721004-006-004]; National Natural Science Foundation of China
   [81774013, 81804221]; Science and Technology Planning Project of Sichuan
   Province, China [2019JDPT0010, 2018JY0237, 2019LZXNYDJ11, 2019YJ0484,
   2019YJ0473]; Educational Commission of Sichuan Province, China
   [18TD0051, 18ZA0525]; Joint project of Luzhou Municipal People's
   Government and Southwest Medical University, China [2018LZXNYD-ZK31];
   Luzhou Science and Technology Project, China [2017-S-39(3/5)];
   Administration of Traditional Chinese Medicine of Sichuan Province,
   China [2018QN070, 2018JC013, 2018JC038]; Southwest Medical University,
   China [2018-ZRZD-001, 2019ZZD006, 2017-ZRZD-017, 2017ZRQN-081]
FX This research was funded by National Key Research and Development
   Program of China (Grant No. 2018ZX09721004-006-004); National Natural
   Science Foundation of China (Grant Nos. 81774013 and 81804221); Science
   and Technology Planning Project of Sichuan Province, China (Grant Nos.
   2019JDPT0010, 2018JY0237, 2019LZXNYDJ11, 2019YJ0484 and 2019YJ0473);
   Educational Commission of Sichuan Province, China (Grant Nos.18TD0051
   and 18ZA0525); Joint project of Luzhou Municipal People's Government and
   Southwest Medical University, China (Grant No. 2018LZXNYD-ZK31), Luzhou
   Science and Technology Project, China (Grant No. 2017-S-39(3/5));
   Administration of Traditional Chinese Medicine of Sichuan Province,
   China (grant Nos. 2018QN070, 2018JC013 and 2018JC038); Southwest Medical
   University, China (Grant Nos. 2018-ZRZD-001, 2019ZZD006, 2017-ZRZD-017
   and 2017ZRQN-081).
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PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 2050-6511
J9 BMC PHARMACOL TOXICO
JI BMC Pharmacol. Toxicol.
PD JUL 17
PY 2021
VL 22
IS 1
AR 45
DI 10.1186/s40360-021-00511-z
PG 10
WC Pharmacology & Pharmacy; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Toxicology
GA TJ7QK
UT WOS:000673671300001
PM 34274011
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Alsaweed, M
AF Alsaweed, Mohammed
TI Oxidative Modification of Lipoproteins: A Potential Role of Oxidized
   Small dense LDL in Enhanced Atherogenicity
SO JOURNAL OF PHARMACEUTICAL RESEARCH INTERNATIONAL
LA English
DT Review
DE Lipoproteins; oxidative modification; sd-LDL; LDL-R; HMG-CoA Reductase
   inhibitors; atherogenicity
ID COA REDUCTASE INHIBITOR; CORONARY-HEART-DISEASE; NITRIC-OXIDE SYNTHASE;
   NUCLEAR-MAGNETIC-RESONANCE; C-REACTIVE PROTEIN; FICUS-VIRENS AIT;
   CARDIOVASCULAR-DISEASE; ENDOTHELIAL DYSFUNCTION; METABOLIC SYNDROME;
   PARTICLE NUMBER
AB Atherosclerosis (AS) is a multifaceted inflammatory syndrome of the arterial wall to which number of mediators have been implicated in lesion progression. Triglyceride (TG)-rich lipoproteins consist of the large diversity of lipoprotein particles that fluctuate in density, size, and apolipoprotein composition. Two foremost phenotypes, on basis of size, chemical configuration, and density, of low-density-lipoprotein (LDL) have been recognized i.e., pattern A, having LDL diameter greater than 25.5nm (large buoyant LDL or lb-LDL) and pattern B, having LDL diameter less than or equal to 25.5nm (small-dense LDL or sd-LDL). Small-dense low-density-lipoprotein (sd-LDL) particles are produced by potential intravascular hydrolysis of TG-rich VLDL particles via lipoprotein lipases (LPLs), hepatic lipases (HLs) and cholesterol ester transfer protein (CETP). sd-LDL is more atherogenic due to its smaller size, increased penetration into the arterial wall, extended plasma half-life, lesser binding affinity for LDL receptors (LDL-R) as well as lower resistance to oxidative stress when equated with lb-LDL. The higher atherogenic potential of sd-LDL is due to its enhanced susceptibility to oxidation, owing to high polyunsaturated fatty acids (PUFA), low cholesterol and Apoprotein B (ApoB) content. An enhanced understanding of sd-LDL metabolism at the molecular level, transport and clearance may result in the development of sd-LDL as an independent predictive marker for AS events and may be used to maintain cholesterol homeostasis and prevent the succession of AS.
C1 [Alsaweed, Mohammed] Majmaah Univ, Coll Appl Med Sci, Dept Med Lab Sci, Al Majmaah 11952, Saudi Arabia.
C3 Majmaah University
RP Alsaweed, M (corresponding author), Majmaah Univ, Coll Appl Med Sci, Dept Med Lab Sci, Al Majmaah 11952, Saudi Arabia.
EM m.alsaweed@mu.edu.sa
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NR 166
TC 1
Z9 1
U1 0
U2 1
PU SCIENCEDOMAIN INT
PI GURGAON
PA SCIENCEDOMAIN INT, GURGAON, 00000, INDIA
SN 2456-9119
J9 J PHARM RES INT
JI J. Pharm. Res. Int.
PY 2021
VL 33
IS 47A
BP 118
EP 140
DI 10.9734/JPRI/2021/v33i47A3299
PG 23
WC Pharmacology & Pharmacy
WE Emerging Sources Citation Index (ESCI)
SC Pharmacology & Pharmacy
GA WR8JP
UT WOS:000714741700016
DA 2025-06-11
ER

PT J
AU Maseroli, E
   Comeglio, P
   Corno, C
   Cellai, I
   Filippi, S
   Mello, T
   Galli, A
   Rapizzi, E
   Presenti, L
   Truglia, MC
   Lotti, F
   Facchiano, E
   Beltrame, B
   Lucchese, M
   Saad, F
   Rastrelli, G
   Maggi, M
   Vignozzi, L
AF Maseroli, E.
   Comeglio, P.
   Corno, C.
   Cellai, I
   Filippi, S.
   Mello, T.
   Galli, A.
   Rapizzi, E.
   Presenti, L.
   Truglia, M. C.
   Lotti, F.
   Facchiano, E.
   Beltrame, B.
   Lucchese, M.
   Saad, F.
   Rastrelli, G.
   Maggi, M.
   Vignozzi, L.
TI Testosterone treatment is associated with reduced adipose tissue
   dysfunction and nonalcoholic fatty liver disease in obese hypogonadal
   men
SO JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
LA English
DT Article
DE Testosterone; Adipose tissue; Liver; NAFLD; Obesity; Hypogonadism
ID LATE-ONSET HYPOGONADISM; METABOLIC SYNDROME; MITOCHONDRIAL DYSFUNCTION;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; BODY-COMPOSITION; HEPATIC
   STEATOSIS; GENE-EXPRESSION; REPLACEMENT THERAPY; SKELETAL-MUSCLE
AB Purpose In both preclinical and clinical settings, testosterone treatment (TTh) of hypogonadism has shown beneficial effects on insulin sensitivity and visceral and liver fat accumulation. This prospective, observational study was aimed at assessing the change in markers of fat and liver functioning in obese men scheduled for bariatric surgery. Methods Hypogonadal patients with consistent symptoms (n = 15) undergoing 27.63 +/- 3.64 weeks of TTh were compared to untreated eugonadal (n = 17) or asymptomatic hypogonadal (n = 46) men. A cross-sectional analysis among the different groups was also performed, especially for data derived from liver and fat biopsies. Preadipocytes isolated from adipose tissue biopsies were used to evaluate insulin sensitivity, adipogenic potential and mitochondrial function. NAFLD was evaluated by triglyceride assay and by calculating NAFLD activity score in liver biopsies. Results In TTh-hypogonadal men, histopathological NAFLD activity and steatosis scores, as well as liver triglyceride content were lower than in untreated-hypogonadal men and comparable to eugonadal ones. TTh was also associated with a favorable hepatic expression of lipid handling-related genes. In visceral adipose tissue and preadipocytes, TTh was associated with an increased expression of lipid catabolism and mitochondrial bio-functionality markers. Preadipocytes from TTh men also exhibited a healthier morpho-functional phenotype of mitochondria and higher insulin-sensitivity compared to untreated-hypogonadal ones. Conclusions The present data suggest that TTh in severely obese, hypogonadal individuals induces metabolically healthier preadipocytes, improving insulin sensitivity, mitochondrial functioning and lipid handling. A potentially protective role for testosterone on the progression of NAFLD, improving hepatic steatosis and reducing intrahepatic triglyceride content, was also envisaged.
C1 [Maseroli, E.; Comeglio, P.; Corno, C.; Cellai, I; Lotti, F.; Rastrelli, G.; Vignozzi, L.] Univ Florence, Dept Expt Clin & Biomed Sci Mario Serio, Androl Womens Endocrinol & Gender Incongruence Un, Viale Pieraccini 6, I-50134 Florence, Italy.
   [Filippi, S.] Univ Florence, Interdept Lab Funct & Cellular Pharmacol Reprod, Viale Pieraccini 6, I-50134 Florence, Italy.
   [Mello, T.; Galli, A.] Univ Florence, Dept Expt Clin & Biomed Sci Mario Serio, Gastroenterol Unit, Viale Pieraccini 6, I-50134 Florence, Italy.
   [Rapizzi, E.; Maggi, M.] Univ Florence, Dept Expt Clin & Biomed Sci Mario Serio, Endocrinol Unit, Viale Pieraccini 6, I-50134 Florence, Italy.
   [Presenti, L.; Truglia, M. C.; Facchiano, E.; Beltrame, B.; Lucchese, M.] Santa Maria Nuova Hosp, Gen Bariatr & Metab Surg Unit, Piazza Santa Maria Nuova 1, I-50122 Florence, Italy.
   [Saad, F.] Bayer AG, Med Affairs, Kaiser Wilhelm Allee 1, D-51373 Leverkusen, Germany.
   [Maggi, M.; Vignozzi, L.] INBB Ist Nazl Biostrutture & Biosistemi, Viale Medaglie dOro 305, I-00136 Rome, Italy.
C3 University of Florence; University of Florence; University of Florence;
   University of Florence; IRCCS Arcispedale S. Maria Nuova; Bayer AG
RP Vignozzi, L (corresponding author), Univ Florence, Dept Expt Clin & Biomed Sci Mario Serio, Androl Womens Endocrinol & Gender Incongruence Un, Viale Pieraccini 6, I-50134 Florence, Italy.; Vignozzi, L (corresponding author), INBB Ist Nazl Biostrutture & Biosistemi, Viale Medaglie dOro 305, I-00136 Rome, Italy.
EM linda.vignozzi@unifi.it
RI Galli, Andrea/AAC-1623-2019; Maggi, Mario/AAB-8284-2019; Maseroli,
   Elisa/AAA-9745-2020; Mello, Tommaso/I-4715-2012; Saad,
   Farid/AAW-2694-2020
OI Rastrelli, Giulia/0000-0002-6164-4278; Galli,
   Andrea/0000-0001-5416-6290; CORNO, CHIARA/0000-0002-0012-6522; MAGGI,
   Mario/0000-0003-3267-4221
FU Bayer AG
FX The original study on which the present article is based was financially
   supported by Bayer AG.
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NR 106
TC 37
Z9 38
U1 0
U2 5
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0391-4097
EI 1720-8386
J9 J ENDOCRINOL INVEST
JI J. Endocrinol. Invest.
PD APR
PY 2021
VL 44
IS 4
BP 819
EP 842
DI 10.1007/s40618-020-01381-8
EA AUG 2020
PG 24
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA QU6OR
UT WOS:000557317800001
PM 32772323
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Hu, X
   Wang, XJ
   Jia, FP
   Tanaka, N
   Kimura, T
   Nakajima, T
   Sato, Y
   Moriya, K
   Koike, K
   Gonzalez, FJ
   Nakayama, J
   Aoyama, T
AF Hu, Xiao
   Wang, Xiaojing
   Jia, Fangping
   Tanaka, Naoki
   Kimura, Takefumi
   Nakajima, Takero
   Sato, Yoshiko
   Moriya, Kyoji
   Koike, Kazuhiko
   Gonzalez, Frank J.
   Nakayama, Jun
   Aoyama, Toshifumi
TI A trans-fatty acid-rich diet promotes liver tumorigenesis in HCV core
   gene transgenic mice
SO CARCINOGENESIS
LA English
DT Article
ID ACTIVATED-RECEPTOR-ALPHA; KAPPA-B; HEPATOCELLULAR-CARCINOMA; HEPATIC
   STEATOSIS; TARGET GENES; CELL-GROWTH; PROTEIN; PROLIFERATION; MYC;
   DISRUPTION
AB Excess consumption of trans-fatty acid (TFA), an unsaturated fatty acid containing trans double bonds, is a major risk factor for cardiovascular disease and metabolic syndrome. However, little is known about the link between TFA and hepatocellular carcinoma (HCC) despite it being a frequent form of cancer in humans. In this study, the impact of excessive dietary TFA on hepatic tumorigenesis was assessed using hepatitis C virus (HCV) core gene transgenic mice that spontaneously developed HCC. Male transgenic mice were treated for 5 months with either a control diet or an isocaloric TFA-rich diet that replaced the majority of soybean oil with shortening. The prevalence of liver tumors was significantly higher in TFA-rich diet-fed transgenic mice compared with control diet-fed transgenic mice. The TFA-rich diet significantly increased the expression of pro-inflammatory cytokines, as well as oxidative and endoplasmic reticulum stress, and activated nuclear factor-kappa B (NF-kappa B) and nuclear factor erythroid 2-related factor 2 (NRF2), leading to high p62/sequestosome 1 (SQSTM1) expression. Furthermore, the TFA diet activated extracellular signal-regulated kinase (ERK) and stimulated the Wnt/beta-catenin signaling pathway, synergistically upregulating cyclin D1 and c-Myc, driving cell proliferation. Excess TFA intake also promoted fibrogenesis and ductular reaction, presumably contributing to accelerated liver tumorigenesis. In conclusion, these results demonstrate that a TFA-rich diet promotes hepatic tumorigenesis, mainly due to persistent activation of NF-kappa B and NRF2-p62/SQSTM1 signaling, ERK and Wnt/beta-catenin pathways and fibrogenesis. Therefore, HCV-infected patients should avoid a TFA-rich diet to prevent liver tumor development.
C1 [Hu, Xiao; Wang, Xiaojing; Jia, Fangping; Tanaka, Naoki; Nakajima, Takero; Aoyama, Toshifumi] Shinshu Univ, Dept Metab Regulat, Sch Med, Asahi 3-1-1, Matsumoto, Nagano 3908621, Japan.
   [Hu, Xiao] Hebei Med Univ, Dept Pathophysiol, Shijiazhuang, Hebei, Peoples R China.
   [Wang, Xiaojing] Zhejiang Univ, Lishui Hosp, Dept Gastroenterol, Sch Med, Lishui, Zhejiang, Peoples R China.
   [Tanaka, Naoki] Shinshu Univ, Res Ctr Social Syst, Matsumoto, Nagano, Japan.
   [Kimura, Takefumi] Shinshu Univ, Sch Med, Dept Gastroenterol, Matsumoto, Nagano, Japan.
   [Sato, Yoshiko; Nakayama, Jun] Shinshu Univ, Sch Med, Dept Mol Pathol, Matsumoto, Nagano, Japan.
   [Moriya, Kyoji] Univ Tokyo, Dept Infect Control & Prevent, Tokyo, Japan.
   [Koike, Kazuhiko] Univ Tokyo, Dept Gastroenterol, Tokyo, Japan.
   [Gonzalez, Frank J.] NCI, Lab Metab, NIH, Bethesda, MD 20892 USA.
C3 Shinshu University; Hebei Medical University; Zhejiang University;
   Shinshu University; Shinshu University; Shinshu University; University
   of Tokyo; University of Tokyo; National Institutes of Health (NIH) -
   USA; NIH National Cancer Institute (NCI)
RP Tanaka, N (corresponding author), Shinshu Univ, Dept Metab Regulat, Sch Med, Asahi 3-1-1, Matsumoto, Nagano 3908621, Japan.
EM naopi@shinshu-u.ac.jp
RI Gonzalez, Francisco/GWV-3999-2022; Wang, Xiaojing/HNI-4384-2023; Kimura,
   Takefumi/D-3412-2011
OI Kimura, Takefumi/0000-0002-1481-1029; Tanaka, Naoki/0000-0002-3212-3836;
   xiaojing, Wang/0000-0001-6921-3619; Gonzalez, Frank/0000-0002-7990-2140
FU JSPS [16K08616]; Grants-in-Aid for Scientific Research [16K08616]
   Funding Source: KAKEN
FX JSPS Grants-in-Aid for Scientific Research (C) (KAKENHI Grant number
   16K08616).
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NR 47
TC 13
Z9 14
U1 0
U2 11
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0143-3334
EI 1460-2180
J9 CARCINOGENESIS
JI Carcinogenesis
PD FEB
PY 2020
VL 41
IS 2
BP 159
EP 170
DI 10.1093/carcin/bgz132
PG 12
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA LT9DI
UT WOS:000537366000005
PM 31300810
OA Green Published
DA 2025-06-11
ER

PT J
AU Mazur-Bialy, AI
AF Mazur-Bialy, Agnieszka Irena
TI Superiority of the Non-Glycosylated Form over the Glycosylated Form of
   Irisin in the Attenuation of Adipocytic Meta-Inflammation: A Potential
   Factor in the Fight against Insulin Resistance
SO BIOMOLECULES
LA English
DT Article
DE non-glycosylated irisin; glycosylated irisin; meta-inflammation;
   obesity; insulin resistance; metabolic syndrome; adipomyokine; physical
   exercise
ID ADIPOSE-TISSUE; MYOKINE IRISIN; OXIDATIVE STRESS; OBESITY; HMGB1;
   SECRETION; EXERCISE; LEPTIN; FAT; CONTRIBUTES
AB Irisin is an adipomyokine that promotes the browning of white adipose tissue and exhibits protective potential against the development of insulin resistance and type 2 diabetes. In our bodies, it occurs in its glycosylated form (G-IR): its activity is still poorly understood, because the majority of studies have used its non-glycosylated counterpart (nG-IR). Glycosylation can affect protein function: therefore, the present study attempted to compare the actions of both forms of irisin toward inflammatory activation of the main component of adipose tissue. The study was carried out in a coculture of 3T3 adipocytes and RAW 264.7 macrophages maintained in the presence of nG-IR or G-IR. The impact on vitality and the expression and release of key inflammatory mediators important for insulin resistance and diabetes development were assessed. The studies showed that both forms effectively inhibited the expression and release of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1 beta, IL-6, macrophage chemotactic protein (MCP)-1, high-mobility group box (HMGB1), leptin, and adiponectin. However, in the case of TNF-alpha, IL-1 beta, MCP-1, and HMGB1, the inhibition exerted by nG-IR was more prominent than that by G-IR. In addition, only nG-IR significantly inhibited macrophage migration. Here, nG-IR seemed to be the stronger inhibitor of the development of obesity-related inflammation; however, G-IR also had anti-inflammatory potential.
C1 [Mazur-Bialy, Agnieszka Irena] Jagiellonian Univ, Fac Hlth Sci, Inst Physiotherapy, Dept Ergon & Exercise Physiol,Med Coll, Grzegorzecka 20, PL-31531 Krakow, Poland.
C3 Jagiellonian University; Collegium Medicum Jagiellonian University
RP Mazur-Bialy, AI (corresponding author), Jagiellonian Univ, Fac Hlth Sci, Inst Physiotherapy, Dept Ergon & Exercise Physiol,Med Coll, Grzegorzecka 20, PL-31531 Krakow, Poland.
EM agnieszka.mazur@uj.edu.pl
RI Mazur-Bialy, Agnieszka/I-4882-2012
OI Mazur-Bialy, Agnieszka/0000-0003-1056-8276
FU  [K/DSC/002108]
FX This study was financially supported by the research project no.
   K/DSC/002108.
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NR 52
TC 18
Z9 18
U1 0
U2 10
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2218-273X
J9 BIOMOLECULES
JI Biomolecules
PD SEP
PY 2019
VL 9
IS 9
AR 394
DI 10.3390/biom9090394
PG 12
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA JC2JH
UT WOS:000489102800006
PM 31438646
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Pedro, EM
   Santos, LFDF
   Scavuzzi, BM
   Iriyoda, TMV
   Peixe, TS
   Lozovoy, MAB
   Reiche, EMV
   Dichi, I
   Simao, ANC
   Santos, MJ
AF Pedro, Eliel Marcio
   da Rosa Franchi Santos, Lorena Flor
   Scavuzzi, Bruna Miglioranza
   Veiga Iriyoda, Tatiana Mayumi
   Peixe, Tiago Severo
   Batiste Lozovoy, Marcell Alysson
   Vissoci Reiche, Edna Maria
   Dichi, Isaias
   Colado Simao, Andrea Name
   Santos, Maria Josefa
TI Trace Elements Associated with Systemic Lupus Erythematosus and Insulin
   Resistance
SO BIOLOGICAL TRACE ELEMENT RESEARCH
LA English
DT Article
DE SLE disease activity index (SLEDAI); Heavy metals; Trace elements;
   Insulin resistance; Glucose homeostasis
ID C-REACTIVE PROTEIN; OXIDATIVE STRESS; DISEASE-ACTIVITY; METABOLIC
   SYNDROME; CADMIUM EXPOSURE; ZINC-DEFICIENCY; SERUM COPPER; DIETARY;
   HEALTH; EXACERBATION
AB Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease of multifactorial origin. Studies have shown that trace elements such as zinc and copper may help maintain optimum function of the immune system and metabolism, while toxic metals such as lead may increase systemic autoimmunity. The current study aimed to assess the relationship between serum concentration of lithium (Li), vanadium (V), copper (Cu), zinc (Zn), molybdenum (Mo), cadmium (Cd), and lead (Pb) and SLE diagnosis, disease activity measured by SLE disease activity index (SLEDAI) and insulin resistance (IR). This case-control, cross-sectional study included 225 patients, 120 healthy controls, and 105 SLE patients. Serum concentration of Li, V, Cu, Zn, Mo, Cd, and Pb was measured. Serum concentrations of V (p<0.001), Zn (p<0.001), and Pb (p<0.001) were lower and Mo (p<0.001) and Li (p<0.001) were higher in patients with SLE compared to healthy controls. SLE diagnosis was associated with higher serum Li (p<0.001) concentration and lower V (p<0.001), Zn (p=0.003), and Pb (p=0.020). Toxic metals and trace elements were not associated with disease activity. Levels of Cd were higher in patients with IR (p=0.042). There was no significant association between IR and the other metals. The results indicate that SLE patients have different profiles of trace elements and toxic metals compared to healthy controls. While some toxic metals and trace elements were found to be associated with SLE diagnosis, they had no effect on disease activity and IR.
C1 [Pedro, Eliel Marcio] Univ Londrina, Dept Chem, Londrina, Parana, Brazil.
   [da Rosa Franchi Santos, Lorena Flor; Scavuzzi, Bruna Miglioranza] Univ Londrina, Res Lab Appl Immunol, Londrina, Parana, Brazil.
   [Veiga Iriyoda, Tatiana Mayumi; Colado Simao, Andrea Name] PUC, Dept Rheumatol, Londrina, Parana, Brazil.
   [Peixe, Tiago Severo; Batiste Lozovoy, Marcell Alysson; Vissoci Reiche, Edna Maria; Colado Simao, Andrea Name; Santos, Maria Josefa] Univ Londrina, Dept Pathol Clin Anal & Toxicol, Rua Robert Koch 60, Londrina, Parana, Brazil.
   [Dichi, Isaias] Univ Londrina, Dept Internal Med, Londrina, Parana, Brazil.
RP Simao, ANC (corresponding author), PUC, Dept Rheumatol, Londrina, Parana, Brazil.; Simao, ANC (corresponding author), Univ Londrina, Dept Pathol Clin Anal & Toxicol, Rua Robert Koch 60, Londrina, Parana, Brazil.
EM deianame@yahoo.com.br
RI Lozovoy, Marcell/AAM-4897-2021; Reiche, EDNa/AAD-4186-2020; Santos,
   Lorena/KIH-3856-2024; Peixe, Tiago/B-7725-2012; Scavuzzi,
   Bruna/AAK-7916-2020; Simão, Andrea/AAM-4892-2021; Reiche, Edna Maria
   Vissoci/C-4102-2013
OI Miglioranza Scavuzzi, Bruna/0000-0001-9609-001X; Reiche, Edna Maria
   Vissoci/0000-0001-6507-2839; Peixe, Tiago/0000-0002-3188-2339
FU Laboratory of Atomic Emission Spectrometry (LAES) from State University
   of Londrina-Parana State, Brazil
FX This study was supported by Laboratory of Atomic Emission Spectrometry
   (LAES) from State University of Londrina-Parana State, Brazil.
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NR 63
TC 24
Z9 24
U1 0
U2 13
PU HUMANA PRESS INC
PI TOTOWA
PA 999 RIVERVIEW DRIVE SUITE 208, TOTOWA, NJ 07512 USA
SN 0163-4984
EI 1559-0720
J9 BIOL TRACE ELEM RES
JI Biol. Trace Elem. Res.
PD SEP
PY 2019
VL 191
IS 1
BP 34
EP 44
DI 10.1007/s12011-018-1592-7
PG 11
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA IL0YC
UT WOS:000477025100005
PM 30600500
DA 2025-06-11
ER

PT J
AU Budzianowski, J
   Hiczkiewicz, J
   Burchardt, P
   Pieszko, K
   Rzezniczak, J
   Budzianowski, P
   Korybalska, K
AF Budzianowski, Jan
   Hiczkiewicz, Jaroslaw
   Burchardt, Pawel
   Pieszko, Konrad
   Rzezniczak, Janusz
   Budzianowski, Pawel
   Korybalska, Katarzyna
TI Predictors of atrial fibrillation early recurrence following cryoballoon
   ablation of pulmonary veins using statistical assessment and machine
   learning algorithms
SO HEART AND VESSELS
LA English
DT Article
DE Atrial fibrillation; Cryoballoon ablation; Early recurrence; Biomarkers;
   Machine learning
ID RADIOFREQUENCY CATHETER ABLATION; MYOCARDIAL INJURY; TACHYARRHYTHMIAS;
   PREVENTION; BIOMARKERS; AF
AB Inflammation, oxidative stress, myocardial injury biomarkers and clinical parameters (longer AF duration, left atrial enlargement, the metabolic syndrome) are factors commonly related to AF recurrence. This study aims to assess the predictive value of laboratory and clinical parameters responsible for early recurrence of atrial fibrillation (ERAF) following cryoballoon ablation (CBA) using statistical assessment and machine learning algorithms. This study group comprised 118 consecutive patients (mean age, 62.5 +/- 7.8years; women 36%) with paroxysmal (54.1%) and persistent (45.9%) AF who underwent their first pulmonary vein isolation (PVI) performed by CBA (Arctic Front Advance 2nd generation 28mm). The biomarker concentrations were measured at baseline and after CBA in a 24-h follow-up. ERAF was defined as at least a 30-s episode of arrhythmia registered by a 24h-Holter monitor within the 3months following the procedure. 56 clinical, laboratory and procedural variables were collected from each patient. We used two classification algorithms: support vector machines, gradient boosted tree. The synthetic minority over-sampling technique (SMOTE) was used to provide a balanced training data set. Within a period of 3months 21 patients (17.8%) experienced ERAF. The statistical analysis indicated that the lowered levels of post-ablation TnT (p=0.043) and CK-MB (p=0.010) with the TnT elevation (p=0.044) were the predictors of ERAF following CBA. In addition, diabetes and statin treatment were significantly associated with ERAF after CBA (p<0.05). The machine learning algorithms confirmed the results obtained in the univariate analysis.
C1 [Budzianowski, Jan; Hiczkiewicz, Jaroslaw; Pieszko, Konrad] Nowa Sol Multidisciplinary Hosp, Dept Cardiol, Nowa Sol, Poland.
   [Budzianowski, Jan; Hiczkiewicz, Jaroslaw; Pieszko, Konrad] Univ Zielona Gora, Fac Med & Hlth Sci, Zielona Gora, Poland.
   [Burchardt, Pawel] Poznan Univ Med Sci, Dept Biol & Lipid Disorders, Poznan, Poland.
   [Burchardt, Pawel; Rzezniczak, Janusz] J Strus Hosp, Dept Cardiol, Poznan, Poland.
   [Budzianowski, Pawel] Univ Cambridge, Dept Engn, Cambridge, England.
   [Korybalska, Katarzyna] Poznan Univ Med Sci, Dept Pathophysiol, Poznan, Poland.
C3 University of Zielona Gora; Poznan University of Medical Sciences;
   University of Cambridge; Poznan University of Medical Sciences
RP Budzianowski, J (corresponding author), Nowa Sol Multidisciplinary Hosp, Dept Cardiol, Nowa Sol, Poland.; Budzianowski, J (corresponding author), Univ Zielona Gora, Fac Med & Hlth Sci, Zielona Gora, Poland.
EM jan.budzianowski@gmail.com
RI Korybalska, Katarzyna/ABG-1654-2021; Pieszko, Konrad/GYE-2249-2022;
   Burchardt, Pawel/AAC-1861-2022; Budzianowski, Jan/JAN-7610-2023;
   Hiczkiewicz, Jarosław/ABC-5678-2021
OI Pieszko, Konrad/0000-0002-5514-7750; Budzianowski,
   Jan/0000-0001-5660-1268
CR Aksu T, 2015, CARDIOVASC J AFR, V26, P165, DOI 10.5830/CVJA-2015-027
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NR 23
TC 30
Z9 34
U1 0
U2 6
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0910-8327
EI 1615-2573
J9 HEART VESSELS
JI Heart Vessels
PD FEB
PY 2019
VL 34
IS 2
BP 352
EP 359
DI 10.1007/s00380-018-1244-z
PG 8
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA HK0IH
UT WOS:000457581800018
PM 30140958
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Deligiannidou, GE
   Philippou, E
   Vidakovic, M
   Berghe, W
   Heraclides, A
   Grdovic, N
   Mihailovic, M
   Kontogiorgis, C
AF Deligiannidou, Georgia-Eirini
   Philippou, Elena
   Vidakovic, Melita
   Berghe, Wim, V
   Heraclides, Alexandros
   Grdovic, Nevena
   Mihailovic, Mirjana
   Kontogiorgis, Christos
TI Natural Products Derived from the Mediterranean Diet with Antidiabetic
   Activity: From Insulin Mimetic Hypoglycemic to Nutriepigenetic Modulator
   Compounds
SO CURRENT PHARMACEUTICAL DESIGN
LA English
DT Review
DE Mediterranean diet; diabetes; natural products; glycaemic control;
   nutri(epi)genetics; pancreatic beta-cell
ID CARDIOVASCULAR RISK-FACTORS; FOENICULUM-VULGARE MILL.; TYPE-2
   DIABETES-MELLITUS; CORIANDRUM-SATIVUM L.; SALVIA-HISPANICA L.; OXIDATIVE
   STRESS; GLYCEMIC CONTROL; DNA-METHYLATION; METABOLIC SYNDROME; FAT DIET
AB Background: The Mediterranean diet is a healthy eating pattern that protects against the development of Type 2 diabetes mellitus (T2DM), a metabolic disease characterized by elevated blood sugar levels due to pancreatic beta-cell functional impairment and insulin resistance in various tissues. Inspired by the ancient communities, this diet emphasizes eating primarily plant-based foods, including vegetables, legumes, fruits, cereals, and nuts. Importantly, virgin olive oil is used as the principal source of fat. Red meat is consumed in low amounts while wine and fish are consumed moderately.
   Objective: Here, we review the most beneficial components of the Mediterranean Diet and tentative mechanisms of action for prevention and/or management of T2DM, based on research conducted within the last decade.
   Methods: The references over the last five years have been reviewed and they have been selected properly according to inclusion/ exclusion criteria.
   Results: Several bioactive diet components were evaluated to prevent inflammation and cytokine-induced oxidative damage, reduce glucose concentration, carbohydrate absorption and increase insulin sensitivity and related gene expression.
   Conclusion: The adherence to a healthy lifestyle, including diet, exercise and habits remains the best approach for the prevention of diabetes as well as frequent check-ups and education. Though diabetes has a strong genetic component, in recent years many reports strongly point to the critical role of lifestyle specific epigenetic modifications in the development of T2DM. It remains to be established how different components of the Mediterranean Diet interact and influence the epigenetic landscape to prevent or treat the disease.
C1 [Deligiannidou, Georgia-Eirini; Kontogiorgis, Christos] Democritus Univ Thrace, Dept Med, Lab Hyg & Environm Protect, Alexandroupolis 68100, Greece.
   [Philippou, Elena] Univ Nicosia, Dept Life & Hlth Sci, Nicosia, Cyprus.
   [Philippou, Elena] Kings Coll London, Diabet & Nutr Sci Div, London, England.
   [Vidakovic, Melita; Grdovic, Nevena; Mihailovic, Mirjana] Univ Belgrade, Inst Biol Res, Dept Mol Biol, Bulevar Despota Stefana 142, Belgrade 11000, Serbia.
   [Berghe, Wim, V] Univ Antwerp, Dept Biomed Sci, Epigenet Signaling Lab PPES, Antwerp, Belgium.
   [Heraclides, Alexandros] Univ Nicosia, Med Sch, Dept Primary Care & Populat Hlth, Ayiou Nikolaou St, Egkomi, Cyprus.
C3 Democritus University of Thrace; University of Nicosia; University of
   London; King's College London; University of Belgrade; University of
   Antwerp; University of Nicosia
RP Kontogiorgis, C (corresponding author), Democritus Univ Thrace, Dept Med, Lab Hyg & Environm Protect, Alexandroupolis 68100, Greece.
EM ckontogi@med.duth.gr
RI Heraclides, Alexandros/AFN-4638-2022; Deligiannidou, Georgia
   Eirini/AAL-4174-2021; Grdovic, Nevena/AEQ-6209-2022; Philippou,
   Elena/G-7284-2015; Vanden Berghe, Wim/S-6425-2018; Vidakovic,
   Melita/G-6747-2016; Mihailovic, Mirjana/E-6308-2015
OI Grdovic, Nevena/0000-0003-1504-4578; Heraclides,
   Alexandros/0000-0002-1304-3275; Philippou, Elena/0000-0003-0300-9572;
   Deligiannidou, Georgia -Eirini/0000-0003-3976-4473; Vanden Berghe,
   Wim/0000-0003-0161-7355; Vidakovic, Melita/0000-0001-8410-6264;
   Mihailovic, Mirjana/0000-0002-8097-1186
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NR 217
TC 6
Z9 6
U1 0
U2 21
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1381-6128
EI 1873-4286
J9 CURR PHARM DESIGN
JI Curr. Pharm. Design
PY 2019
VL 25
IS 15
BP 1760
EP 1782
DI 10.2174/1381612825666190705191000
PG 23
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA IR7SZ
UT WOS:000481642500009
PM 31298162
DA 2025-06-11
ER

PT J
AU Sadeghabadi, ZA
   Nourbakhsh, M
   Pasalar, P
   Emamgholipour, S
   Golestani, A
   Larijani, B
   Razzaghy-Azar, M
AF Sadeghabadi, Zahra Arab
   Nourbakhsh, Mitra
   Pasalar, Parvin
   Emamgholipour, Solaleh
   Golestani, Abolfazl
   Larijani, Bagher
   Razzaghy-Azar, Maryam
TI Reduced gene expression of sirtuins and active AMPK levels in children
   and adolescents with obesity and insulin resistance
SO OBESITY RESEARCH & CLINICAL PRACTICE
LA English
DT Article
DE Sirtuin 1; Sirtuin 2; AMP-activated protein kinase; Obesity; Children
ID ADIPOSE-TISSUE; METABOLIC SYNDROME; DIABETES-MELLITUS; CHILDHOOD
   OBESITY; OXIDATIVE STRESS; RISK-FACTORS; SIRT1; LONGEVITY; CELLS
AB Background: Sirtuins, including SIRT1 and SIRT2, are longevity-associated deacetylase enzymes that modulate metabolic homeostasis in response to the cellular energy state. Adenosine monophosphate activated protein kinase (AMPK) and SIRT1 are interrelated and share several common target pathways. This study aimed to evaluate the SIRT1 and SIRT2 gene expression in peripheral blood mononuclear cells (PBMCs) as well as plasma levels of AMPK, in obese children and adolescents.
   Materials and methods: Participants included 60 children and adolescents (30 obese and 30 age- and gender-matched control subjects). Real-time polymerase chain reaction (PCR) was used to assess the SIRT1 and SIRT2 gene expression in PBMCs. Serum phospho-AMPK and insulin were measured using enzyme-linked immunosorbent assay (ELISA), and insulin resistance (IR) was calculated by the Homeostasis Model of Assessment of Insulin Resistance (HOMA-IR). Glucose and lipid profile were also measured.
   Results: SIRT1 gene expression and phospho-AMPK plasma levels were significantly diminished in obese subjects compared to the control group, and both SIRT1 and SIRT2 were significantly lower in obese children with IR compared to those without IR. SIRT1 expression revealed significant negative correlations with body mass index and waist circumference as well as insulin and HOMA-IR and a positive correlation with AMPK. SIRT2 negatively correlated with SIRT1 and positively correlated with high density lipoprotein-cholesterol (HDL-C).
   Conclusion: SIRT1 and SIRT2 expression and AMPK levels decrease in children with obesity and IR. Targeting SIRT1 can be valuable in preventing obesity-associated IR in childhood and adolescence. (c) 2017 Asia Oceania Association for the Study of Obesity. Published by Elsevier Ltd. All rights reserved.
C1 [Sadeghabadi, Zahra Arab; Pasalar, Parvin; Emamgholipour, Solaleh; Golestani, Abolfazl] Univ Tehran Med Sci, Fac Med, Dept Biochem, Tehran, Iran.
   [Sadeghabadi, Zahra Arab; Pasalar, Parvin; Razzaghy-Azar, Maryam] Univ Tehran Med Sci, Metab Disorders Res Ctr, Endocrinol & Metab Mol Cellular Sci Inst, Tehran, Iran.
   [Nourbakhsh, Mitra] Iran Univ Med Sci, Fac Med, Dept Biochem, Tehran 1449614535, Iran.
   [Larijani, Bagher] Univ Tehran Med Sci, Endocrinol & Metab Res Ctr, Endocrinol & Metab Res Inst, Tehran, Iran.
   [Razzaghy-Azar, Maryam] Iran Univ Med Sci, H Aliasghar Childrens Hosp, Tehran, Iran.
C3 Tehran University of Medical Sciences; Tehran University of Medical
   Sciences; Iran University of Medical Sciences; Tehran University of
   Medical Sciences; Iran University of Medical Sciences
RP Nourbakhsh, M (corresponding author), Iran Univ Med Sci, Fac Med, Dept Biochem, Tehran 1449614535, Iran.
EM Nourbakhsh.m@iums.ac.ir
RI larijani, Bagher/ABE-3315-2020; Nourbakhsh, Mitra/D-5214-2018;
   Emamgholipour, Solaleh/T-6035-2017; Razzaghy-Azar, Maryam/E-4968-2011
OI arab sadeghabadi, zahra/0000-0002-8627-1754; Emamgholipour,
   Solaleh/0000-0002-9949-5773
FU Endocrinology and Metabolism Research Institute, Tehran University of
   Medical Sciences [1392-02-104-1707]
FX This research was financially supported by Endocrinology and Metabolism
   Research Institute, Tehran University of Medical Sciences; grant number:
   1392-02-104-1707. We would like to thank Dr. Farideh Razi, Dr. Camelia
   Rambod and the staff of Diabetes Clinic 1 laboratory for their help and
   support.
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SN 1871-403X
EI 1878-0318
J9 OBES RES CLIN PRACT
JI Obes. Res. Clin. Pract.
PD MAR-APR
PY 2018
VL 12
IS 2
BP 167
EP 173
DI 10.1016/j.orcp.2017.10.004
PG 7
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA GG1LJ
UT WOS:000432448200005
PM 29150224
DA 2025-06-11
ER

PT J
AU Boyle, KE
   Patinkin, ZW
   Shapiro, ALB
   Bader, C
   Vanderlinden, L
   Kechris, K
   Janssen, RC
   Ford, RJ
   Smith, BK
   Steinberg, GR
   Davidson, EJ
   Yang, IV
   Dabelea, D
   Friedman, JE
AF Boyle, Kristen E.
   Patinkin, Zachary W.
   Shapiro, Allison L. B.
   Bader, Carly
   Vanderlinden, Lauren
   Kechris, Katerina
   Janssen, Rachel C.
   Ford, Rebecca J.
   Smith, Brennan K.
   Steinberg, Gregory R.
   Davidson, Elizabeth J.
   Yang, Ivane V.
   Dabelea, Dana
   Friedman, Jacob E.
TI Maternal obesity alters fatty acid oxidation, AMPK activity, and
   associated DNA methylation in mesenchymal stem cells from human infants
SO MOLECULAR METABOLISM
LA English
DT Article
DE Maternal/fetal; Obesity; AMPK; Lipid metabolism; Mesenchymal stem cells
ID METABOLIC SYNDROME; LIPID OXIDATION; ADIPOSE-TISSUE; BIRTH-WEIGHT;
   INSULIN; DIFFERENTIATION; EXPRESSION; HOMEOSTASIS; EXPOSURE; MYOCYTES
AB Objective: Infants born to mothers with obesity have greater adiposity, ectopic fat storage, and are at increased risk for childhood obesity and metabolic disease compared with infants of normal weight mothers, though the cellular mechanisms mediating these effects are unclear. Methods: We tested the hypothesis that human, umbilical cord-derived mesenchymal stem cells (MSCs) from infants born to obese (Ob-MSC) versus normal weight (NW-MSC) mothers demonstrate altered fatty acid metabolism consistent with adult obesity. In infant MSCs undergoing myogenesis in vitro, we measured cellular lipid metabolism and AMPK activity, AMPK activation in response to cellular nutrient stress, and MSC DNA methylation and mRNA content of genes related to oxidative metabolism. Results: We found that Ob-MSCs exhibit greater lipid accumulation, lower fatty acid oxidation (FAO), and dysregulation of AMPK activity when undergoing myogenesis in vitro. Further experiments revealed a clear phenotype distinction within the Ob-MSC group where more severe MSC metabolic perturbation corresponded to greater neonatal adiposity and umbilical cord blood insulin levels. Targeted analysis of DNA methylation array revealed Ob-MSC hypermethylation in genes regulating FAO (PRKAG2, ACC2, CPT1A, SDHC) and corresponding lower mRNA content of these genes. Moreover, MSC methylation was positively correlated with infant adiposity. Conclusions: These data suggest that greater infant adiposity is associated with suppressed AMPK activity and reduced lipid oxidation in MSCs from infants born to mothers with obesity and may be an important, early marker of underlying obesity risk. (C) 2017 The Authors. Published by Elsevier GmbH.
C1 [Boyle, Kristen E.; Patinkin, Zachary W.; Bader, Carly] Univ Colorado, Sch Med, Dept Pediat, Sect Nutr, Aurora, CO 80045 USA.
   [Shapiro, Allison L. B.] Colorado Sch Publ Hlth, Dept Epidemiol, Aurora, CO USA.
   [Vanderlinden, Lauren; Kechris, Katerina; Dabelea, Dana] Colorado Sch Publ Hlth, Dept Biostat & Bioinformat, Aurora, CO USA.
   [Janssen, Rachel C.; Friedman, Jacob E.] Univ Colorado, Sect Neonatol, Sch Med, Dept Pediat, Aurora, CO 80045 USA.
   [Ford, Rebecca J.; Smith, Brennan K.; Steinberg, Gregory R.] McMaster Univ, Dept Med, Hamilton, ON, Canada.
   [Steinberg, Gregory R.] McMaster Univ, Dept Biochem & Biomed Sci, Hamilton, ON, Canada.
   [Davidson, Elizabeth J.; Yang, Ivane V.] Univ Colorado, Dept Med, Sch Med, Aurora, CO 80045 USA.
   [Dabelea, Dana] Univ Colorado, Sch Med, Dept Pediat, Aurora, CO 80045 USA.
   [Dabelea, Dana] Lifecourse Epidemiol Adipos & Diabet LEAD Ctr, Aurora, CO 80045 USA.
C3 University of Colorado System; University of Colorado Anschutz Medical
   Campus; Colorado School of Public Health; Colorado School of Public
   Health; University of Colorado System; University of Colorado Anschutz
   Medical Campus; McMaster University; McMaster University; University of
   Colorado System; University of Colorado Anschutz Medical Campus;
   University of Colorado System; University of Colorado Anschutz Medical
   Campus
RP Boyle, KE (corresponding author), Univ Colorado, Dept Pediat, Anschutz Med Campus,MS C225,12700 E 19th Ave, Aurora, CO 80045 USA.
EM kristen.boyle@ucdenver.edu
RI Steinberg, Greg/ACI-2304-2022; Yang, Ivana/P-3059-2018; Boyle,
   Kristen/N-7442-2018
OI Kechris, Katerina/0000-0002-3725-5459; Steinberg,
   Gregory/0000-0001-5425-8275; Patinkin, Zachary/0000-0001-5946-6217;
   Boyle, Kristen/0000-0001-9689-3322
FU Obesity Society; University of Colorado Center for Women's Health
   Research; Canadian Institutes of Health Research; Genomics and
   Microarray Shared Resource of Colorado's NIH/NCI Cancer Center
   [P30CA046934]; National Institutes of Health (NIH) [K12HD057022,
   K01DK106347]; American Heart Association [14PRE18230008]; Colorado
   Nutrition and Obesity Research Center (NORC; NIH) [P30DK048520]; NIH
   [R01DK076648]; NIH/NCATS Colorado CTSA [UL1TR001082]; American Heart
   Association (AHA) [14PRE18230008] Funding Source: American Heart
   Association (AHA)
FX This work was supported by grants from The Obesity Society (KEB), the
   University of Colorado Center for Women's Health Research (KEB), the
   Canadian Institutes of Health Research (GRS), and the Genomics and
   Microarray Shared Resource of Colorado's NIH/NCI Cancer Center
   (P30CA046934). KEB was supported by National Institutes of Health (NIH,
   K12HD057022 and K01DK106347). GRS is a Canada Research Chair in
   Metabolism and Obesity and the J. Bruce Duncan Chair in Metabolic
   Diseases. The Healthy Start BabyBUMP Project was supported by grants
   from the American Heart Association (14PRE18230008, ALBS), the Colorado
   Nutrition and Obesity Research Center (NORC; NIH, P30DK048520), and by
   the parent Healthy Start study: (NIH, R01DK076648, DD) and NIH/NCATS
   Colorado CTSA (UL1TR001082). Contents are the authors' sole
   responsibility and do not necessarily represent official views of the
   funding agencies.
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NR 48
TC 59
Z9 67
U1 0
U2 20
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2212-8778
J9 MOL METAB
JI Mol. Metab.
PD NOV
PY 2017
VL 6
IS 11
BP 1503
EP 1516
DI 10.1016/j.molmet.2017.08.012
PG 14
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA FR5CK
UT WOS:000419084000015
PM 29107296
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Marino, JS
   Stechschulte, LA
   Stec, DE
   Nestor-Kalinoski, A
   Coleman, S
   Hinds, TD
AF Marino, Joseph S.
   Stechschulte, Lance A.
   Stec, David E.
   Nestor-Kalinoski, Andrea
   Coleman, Sydni
   Hinds, Terry D., Jr.
TI Glucocorticoid Receptor β Induces Hepatic Steatosis by Augmenting
   Inflammation and Inhibition of the Peroxisome Proliferator-activated
   Receptor (PPAR) α
SO JOURNAL OF BIOLOGICAL CHEMISTRY
LA English
DT Article
ID GROWTH-FACTOR 21; FATTY LIVER-DISEASE; GLYCOGEN-SYNTHASE KINASE-3-BETA;
   DIET-INDUCED OBESITY; INSULIN-RESISTANCE; GENE-EXPRESSION; METABOLIC
   SYNDROME; MICE LACKING; NONALCOHOLIC STEATOHEPATITIS; LIPID-METABOLISM
AB Glucocorticoids (GCs) regulate energy supply in response to stress by increasing hepatic gluconeogenesis during fasting. Long-term GC treatment induces hepatic steatosis and weight gain. GC signaling is coordinated via the GC receptor (GR) GR alpha, as the GR beta isoform lacks a ligand-binding domain. The roles of the GR isoforms in the regulation of lipid accumulation is unknown. The purpose of this study was to determine whether GR beta inhibits the actions of GCs in the liver, or enhances hepatic lipid accumulation. We show that GR beta expression is increased in adipose and liver tissues in obese high-fat fed mice. Adenovirus-mediated delivery of hepatic GR beta overexpression (GR beta-Ad) resulted in suppression of gluconeogenic genes and hyperglycemia in mice on a regular diet. Furthermore, GR beta-Ad mice had increased hepatic lipid accumulation and serum triglyceride levels possibly due to the activation of NF-kappa B signaling and increased tumor necrosis factor alpha (TNF alpha) and inducible nitric-oxide synthase expression, indicative of enhanced M1 macrophages and the development of steatosis. Consequently, GR beta-Ad mice had increased glycogen synthase kinase 3 beta (GSK3 beta) activity and reduced hepatic PPAR alpha and fibroblast growth factor 21 (FGF21) expression and lower serum FGF21 levels, which are two proteins known to increase during fasting to enhance the burning of fat by activating the beta-oxidation pathway. In conclusion, GR beta antagonizes the GC-induced signaling during fasting via GR alpha and the PPAR alpha-FGF21 axis that reduces fat burning. Furthermore, hepatic GR beta increases inflammation, which leads to hepatic lipid accumulation.
C1 [Marino, Joseph S.] Univ N Carolina, Dept Kinesiol, Lab Syst Physiol, Charlotte, NC 28223 USA.
   [Stechschulte, Lance A.] Univ Toledo, Coll Med, Dept Orthoped, Toledo, OH 43614 USA.
   [Nestor-Kalinoski, Andrea] Univ Toledo, Coll Med, Adv Microscopy & Imaging Ctr, Dept Surg, Toledo, OH 43614 USA.
   [Hinds, Terry D., Jr.] Univ Toledo, Coll Med, Ctr Hypertens & Personalized Med, Dept Physiol & Pharmacol, Toledo, OH 43614 USA.
   [Stec, David E.] Univ Mississippi, Med Ctr, Cardiovasc Renal Res Ctr, Dept Physiol & Biophys,Mississippi Ctr Obes Res, Jackson, MS 39216 USA.
   [Coleman, Sydni] Univ Cincinnati, Coll Med, Cincinnati, OH 45220 USA.
C3 University of North Carolina; University of North Carolina Charlotte;
   University System of Ohio; University of Toledo; University System of
   Ohio; University of Toledo; University System of Ohio; University of
   Toledo; University of Mississippi; University of Mississippi Medical
   Center; University System of Ohio; University of Cincinnati
RP Hinds, TD (corresponding author), Univ Toledo, Coll Med, 3000 Arlington Ave,Mail Stop 1008, Toledo, OH 43614 USA.
EM Terry.Hinds@utoledo.edu
RI Marino, Joseph/AGH-6058-2022; Hinds, Terry/B-8495-2015
OI Marino, Joseph/0000-0002-6207-5986; Hinds, Terry/0000-0002-7599-1529;
   Stechschulte, Lance/0000-0001-9783-6194
FU University of Toledo deArce-Memorial Endowment Fund; National Institutes
   of Health [L32MD009154]; NHLBI [K01HL-125445, PO1HL-051971, HL088421];
   NIGMS [P20GM-104357]
FX This work was supported by the University of Toledo deArce-Memorial
   Endowment Fund (to T. D. H), National Institutes of Health Grant
   L32MD009154 (to T. D. H.), NHLBI Grants K01HL-125445 (to T. D. H.),
   PO1HL-051971, and HL088421 (to D. E. S.), and NIGMS Grant P20GM-104357
   (to D. E. S.). The authors declare that they have no conflict of
   interests with the contents of this article. The content is solely the
   responsibility of the authors and does not necessarily represent the
   official views of the National Institutes of Health.
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NR 66
TC 67
Z9 78
U1 0
U2 21
PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3996 USA
EI 1083-351X
J9 J BIOL CHEM
JI J. Biol. Chem.
PD DEC 9
PY 2016
VL 291
IS 50
BP 25776
EP 25788
DI 10.1074/jbc.M116.752311
PG 13
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA EF5BH
UT WOS:000390345200002
PM 27784782
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Bach, E
   Moller, AB
   Jorgensen, JOL
   Vendelbo, MH
   Jessen, N
   Pedersen, SB
   Nielsen, TS
   Moller, N
AF Bach, Ermina
   Moller, Andreas B.
   Jorgensen, Jens O. L.
   Vendelbo, Mikkel H.
   Jessen, Niels
   Pedersen, Steen B.
   Nielsen, Thomas S.
   Moller, Niels
TI Stress hormone release is a key component of the metabolic response to
   lipopolysaccharide: studies in hypopituitary and healthy subjects
SO EUROPEAN JOURNAL OF ENDOCRINOLOGY
LA English
DT Article
ID GENE 2 G0S2; ADIPOSE-TISSUE; INSULIN-RESISTANCE; PROTEIN-METABOLISM;
   GROWTH-HORMONE; GLUCOSE KINETICS; SKELETAL-MUSCLE; MESSENGER-RNA;
   ENDOTOXIN; LIPOLYSIS
AB Objective: Acute and chronic inflammatory and metabolic responses are generated by lipopolysaccharide (LPS) during acute illness and in the pathogenesis of the metabolic syndrome, type 2 diabetes and cardiovascular disease, but whether these responses depend on intact pituitary release of hormones are not clearly identified. We compared the metabolic effects of LPS in hypopituitary patients (HPs) (in the absence of growth hormone (GH) and ACTH responses) and healthy control subjects (CTR) (with normal pituitary hormone responses).
   Design: Single-blind randomized.
   Methods: We compared the effects of LPS on glucose, protein and lipid metabolism in eight HP and eight matched CTR twice during 4-h basal and 2-h hyperinsulinemic-euglycemic clamp conditions with muscle and fat biopsies in each period during infusion with saline or LPS.
   Results: LPS increased cortisol and GH levels in CTR but not in HP. Also, it increased whole-body palmitate fluxes (3-fold) and decreased palmitate-specific activity (SA) 40-50% in CTR, but not in HP. G(0)/G(1) Switch Gene 2 (G0S2 - an inhibitor of lipolysis) adipose tissue (AT) mRNA was decreased in CTR. Although LPS increased phenylalanine fluxes significantly more in CTR, there was no difference in glucose metabolism between groups and intramyocellular insulin signaling was unaltered in both groups.
   Conclusions: LPS increased indices of lipolysis and amino acid/protein fluxes significantly more in CTR compared with HP and decreased adipocyte G0S2 mRNA only in CTR. Thus, in humans intact pituitary function and appropriate cortisol and GH release are crucial components of the metabolic response to LPS.
C1 [Bach, Ermina; Moller, Andreas B.; Jorgensen, Jens O. L.; Vendelbo, Mikkel H.; Jessen, Niels; Pedersen, Steen B.; Nielsen, Thomas S.; Moller, Niels] Dept Clin Med, Med Res Labs, Aarhus N, Denmark.
   [Bach, Ermina; Moller, Andreas B.; Jorgensen, Jens O. L.; Jessen, Niels; Pedersen, Steen B.; Nielsen, Thomas S.; Moller, Niels] Aarhus Univ Hosp, Dept Endocrinol & Internal Med, Aarhus C, Denmark.
   [Vendelbo, Mikkel H.] Aarhus Univ Hosp, Dept Nucl Med, Aarhus C, Denmark.
   [Vendelbo, Mikkel H.] Aarhus Univ Hosp, PET Ctr, Aarhus C, Denmark.
   [Nielsen, Thomas S.] Univ Copenhagen, Fac Hlth & Med Sci, Sect Integrat Physiol, Novo Nordisk Fdn Ctr Basic Metab Res, Copenhagen, Denmark.
C3 Aarhus University; Aarhus University; Aarhus University; University of
   Copenhagen; Novo Nordisk Foundation
RP Bach, E (corresponding author), Dept Clin Med, Med Res Labs, Aarhus N, Denmark.; Bach, E (corresponding author), Aarhus Univ Hosp, Dept Endocrinol & Internal Med, Aarhus C, Denmark.
EM Bach.Ermina@gmail.com
RI Jessen, Niels/E-1731-2011; Pedersen, Steen/AAB-3331-2019; Nielsen,
   Thomas/A-2816-2012; Velentzas, Athanassios/C-1261-2011; Jorgensen,
   Jens/O-8003-2019; Moller, Niels/E-5091-2011
OI Bach, Ermina/0000-0002-7649-5658; Nielsen, Thomas
   Svava/0000-0002-9457-8000; Vendelbo, Mikkel Holm/0000-0003-0431-2522;
   Jessen, Niels/0000-0001-5613-7274; Moller, Niels/0000-0001-5627-7322;
   Pedersen, Steen B./0000-0002-7838-8063
FU Lundbeck Foundation, Denmark
FX This work was supported by the The Lundbeck Foundation, Denmark.
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NR 48
TC 6
Z9 7
U1 0
U2 6
PU BIOSCIENTIFICA LTD
PI BRISTOL
PA STARLING HOUSE, 1600 BRISTOL PARKWAY N, BRISTOL, ENGLAND
SN 0804-4643
EI 1479-683X
J9 EUR J ENDOCRINOL
JI Eur. J. Endocrinol.
PD NOV
PY 2016
VL 175
IS 5
BP 455
EP 465
DI 10.1530/EJE-16-0444
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA EA8UD
UT WOS:000386913600016
PM 27562403
OA Bronze
DA 2025-06-11
ER

PT J
AU Oarada, M
   Takahashi-Nakaguchi, A
   Abe, T
   Nikawa, T
   Miki, T
   Gonoi, T
AF Oarada, Motoko
   Takahashi-Nakaguchi, Azusa
   Abe, Tomoki
   Nikawa, Takeshi
   Miki, Takashi
   Gonoi, Tohru
TI Refeeding with glucose rather than fructose elicits greater hepatic
   inflammatory gene expression in mice
SO NUTRITION
LA English
DT Article
DE Acute starvation; Carbohydrate; Inflammatory gene expression; Glucose;
   Refeeding
ID NF-KAPPA-B; METABOLIC SYNDROME; STEATOSIS; RISK; DIET
AB Objective: We previously reported that refeeding after a 48-h fast, used as a study model of starvation and refeeding, promotes acute liver inflammatory gene expression, which is at least partly mediated by toll-like receptor 2 (TLR2). We also previously demonstrated that dietary carbohydrates play critical roles in this process. The aim of this study was to compare the outcomes of refeeding with different carbohydrate sources.
   Methods: Mice were fasted for 46 h and then refed with 1.5% (w/w) agar gel containing 19% carbohydrate (sources: alpha-cornstarch, glucose, sucrose, or fructose). The liver expression of inflammatory and other specific genes was then sequentially measured for the first 14 h after refeeding initiation.
   Results: Fasting for 46 h up-regulated the liver expression of endogenous ligands for TLRs (HspA5, Hsp90 aal, and Hspd1). Refeeding with agar gel containing alpha-cornstarch or glucose increased the liver expression of Tlr2, proinflammatory genes (Cxcl2, Cxcl10, Cxcl1, Nfkb1, Nfkb2, RelB, Sectm1 alpha, 1110), stress response genes (Atf3, Asns, Gadd45 a, Perk, Inhbe), detoxification genes (Hmox1, Gsta1, Abca8b), genes involved in tissue regeneration (Gdf15, Krt23, Myc, Tnfrsf12a, Mthfd2), and genes involved in tumor suppression (p53, Txnrd1, Btg2). This refeeding also moderately but significantly elevated the serum levels of alanine aminotransferase. These effects were attenuated in mice refed with agar gel containing sucrose or fructose.
   Conclusion: Dietary glucose, rather than fructose, plays a critical role in refeeding-induced acute liver inflammatory gene expression and moderate hepatocyte destruction. Further studies are recommended regarding the role of these effects in liver inflammation and, consequently, liver dysfunction. (C) 2015 Elsevier Inc. All rights reserved.
C1 [Oarada, Motoko; Takahashi-Nakaguchi, Azusa; Gonoi, Tohru] Chiba Univ, Med Mycol Res Ctr, Chiba, Japan.
   [Abe, Tomoki; Nikawa, Takeshi] Univ Tokushima, Sch Med, Dept Nutr, Tokushima 770, Japan.
   [Miki, Takashi] Chiba Univ, Grad Sch Med, Dept Med Physiol, Chiba, Japan.
C3 Chiba University; Tokushima University; Chiba University
RP Oarada, M (corresponding author), Chiba Univ, Med Mycol Res Ctr, Chiba, Japan.
EM Motoko.o@faculty.chiba-u.jp
RI MIKI, Takashi/ABD-3995-2020; Takahashi-Nakaguchi, Azusa/IUN-8301-2023;
   gonoi, tohru/AAC-5181-2021; Abe, Tomoki/AAY-2125-2020
OI gonoi, tohru/0000-0003-3655-7911; Abe, Tomoki/0000-0002-0349-8487
FU Ministry of Education, Culture, Sports, Science and Technology of Japan
   [24580174]; Grants-in-Aid for Scientific Research [25670116, 24580174]
   Funding Source: KAKEN
FX This study was supported in part by a Grant-in Aid for Science Research
   (no. 24580174) from the Ministry of Education, Culture, Sports, Science
   and Technology of Japan. MO performed the experiment and analyses and
   wrote the manuscript. ATN and TA assisted with the experiments. TN and
   TM interpreted the data. TG wrote the manuscript.
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NR 29
TC 9
Z9 10
U1 0
U2 7
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0899-9007
EI 1873-1244
J9 NUTRITION
JI Nutrition
PD MAY
PY 2015
VL 31
IS 5
BP 757
EP 765
DI 10.1016/j.nut.2014.11.014
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA CF4LZ
UT WOS:000352521900021
PM 25837224
DA 2025-06-11
ER

PT J
AU Dullaart, RPF
   Otvos, JD
   James, RW
AF Dullaart, Robin P. F.
   Otvos, James D.
   James, Richard W.
TI Serum paraoxonase-1 activity is more closely related to HDL particle
   concentration and large HDL particles than to HDL cholesterol in Type 2
   diabetic and non-diabetic subjects
SO CLINICAL BIOCHEMISTRY
LA English
DT Article
DE Paraoxonase-1 activity; High density lipoproteins; High density
   lipoprotein subfractions; Type 2 diabetes mellitus
ID HIGH-DENSITY-LIPOPROTEIN; NUCLEAR-MAGNETIC-RESONANCE;
   CORONARY-ARTERY-DISEASE; C-REACTIVE PROTEIN; METABOLIC SYNDROME;
   OXIDATIVE STRESS; THERAPEUTIC TARGET; ENZYME-ACTIVITY; PON1 ACTIVITY; I
   ACTIVITY
AB Objectives: We determined relationships of the anti-oxidative enzyme, paraoxonase-1 (PON-1), with high density lipoprotein (HDL) subfractions, and tested whether these relationships are stronger than those with HDL cholesterol and apolipoprotein A-I (apoA-I) in subjects with and without type 2 diabetes mellitus (T2DM).
   Design and methods: Serum PON-1 (arylesterase activity) and HDL subfractions (nuclear magnetic resonance spectroscopy) were determined in 67 T2DM patients and in 56 non-diabetic subjects.
   Results: PON-1 activity, HDL cholesterol and apoA-Iwere decreased in T2DM (all p < 0.05). The HDL particle concentration was unaltered, but large HDL particles, medium HDL particles and HDL particle size were decreased, whereas small HDL particles were increased in T2DM (all p < 0.05). PON-1 was more closely related to HDL cholesterol than to apoA-I (p = 0.001). In turn, the positive relationship of PON-1 with the HDL particle concentration and with large HDL particles was stronger than that with HDL cholesterol (both p < 0.01). The inverse relationship of PON-1 with T2DM was only modestly attenuated by HDL cholesterol or HDL particle characteristics.
   Conclusions: PON-1 activity is more closely related to the HDL particle concentration or large HDL particles than to HDL cholesterol. Impaired PON-1 activity in T2DM is not to a considerable extent explained by altered HDL subfraction levels. (C) 2014 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
C1 [Dullaart, Robin P. F.] Univ Groningen, Univ Med Ctr Groningen, Dept Endocrinol, NL-9700 RB Groningen, Netherlands.
   [Otvos, James D.] LipoScience Inc, Raleigh, NC USA.
   [James, Richard W.] Univ Hosp Geneva, Div Endocrinol Diabetol Hypertens & Nutr, Geneva, Switzerland.
C3 University of Groningen; LipoScience, Inc; University of Geneva
RP Dullaart, RPF (corresponding author), Univ Groningen, Univ Med Ctr Groningen, Dept Endocrinol, POB 30001, NL-9700 RB Groningen, Netherlands.
EM r.p.f.dullaart@umcg.nl; jotvos@liposcience.com; Richard.James@hcuge.ch
FU Dutch Diabetes Research Foundation [2001.00.012]; Swiss National
   Research Foundation; LipoScience Inc. (Raleigh, North Carolina, USA)
FX Dr. R. P. F. Dullaart, MD, PhD is supported by a grant from the Dutch
   Diabetes Research Foundation (grant 2001.00.012). Dr. R. de Vries, MD,
   PhD is acknowledged for data collection. Dr. R. W. James is supported by
   the Swiss National Research Foundation and is a member of COST Action
   BM0904. The analytical help of Dr. L. D. Dikkeschei, PhD, Laboratory of
   Clinical Chemistry, Isala Clinics, Zwolle, The Netherlands, in plasma
   lipid and apolipoprotein measurement is greatly appreciated. Serum
   paraoxonase-1 activity was measured by Dr. H. A. M. Voorbij, PhD,
   Laboratory of Clinical Chemistry and Hematology, University Medical
   Center, Utrecht, The Netherlands. The NMR lipoprotein measurements are
   funded by LipoScience Inc. (Raleigh, North Carolina, USA).
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NR 47
TC 38
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PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0009-9120
EI 1873-2933
J9 CLIN BIOCHEM
JI Clin. Biochem.
PD AUG
PY 2014
VL 47
IS 12
BP 1022
EP 1027
DI 10.1016/j.clinbiochem.2014.04.013
PG 6
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA AO0JW
UT WOS:000340995900008
PM 24769273
DA 2025-06-11
ER

PT J
AU Joé, JG
   Dósa, A
   Ránky, M
   Pavlik, G
AF Joe, J. G.
   Dosa, A.
   Ranky, M.
   Pavlik, G.
TI Cardiovascular results of an individually controlled complex prevention
SO ACTA PHYSIOLOGICA HUNGARICA
LA English
DT Article
DE prevention; life style modification; physical activity; cardiovascular
   risk factors; blood lipids
ID BLOOD-PRESSURE REDUCTION; ALL-CAUSE MORTALITY; PHYSICAL-ACTIVITY;
   CARDIORESPIRATORY FITNESS; METABOLIC SYNDROME; HEALTHY-MEN; EXERCISE;
   HYPERTENSION; RISK; LIPIDS
AB Lifestyle modifications (increased level of physical activity, favourable nutrition, and stress management) are important factors in the prevention of and the therapy for cardiovascular (CV) diseases. Objectives: The effects of an individualized, half-year long exercise program on CV risk factors were investigated in 50 patients with moderately high CV risk factors. Patients and methods: 75 subjects participated in the study. After the eleventh week of regular training, members of Group A performed 55-65 minutes of exercise at 4-5 times a week, while patients in Group B took part in 45-55 minute training sessions at 2-3 times a week. Activities were monitored using POLAR devices and controlled by a cardiologist and an exercise training expert. Members of the control group (C) were also affected by risk factors, they, however, were not involved in any physical activity. Results: A marked improvement was seen in performance level (62% in Group A, 38% in Group B). There was a decrease in the LDL-cholesterol level (30% and 21%), total cholesterol (16% and 14%), triglyceride (23% in both groups), and an increase in the HDL-cholesterol level (53% and 26%). Body mass (BM) decreased in both groups (8.7% and 5%). In addition, a decrease was also seen in the resting heart rate (HR) (9.6% and 4.5%) and blood pressure (BP: systolic 8.5% and 5.5 %, diastolic 7% and 4.7%). Conclusions: In persons affected by CV risk factors, lifestyle modification with personal, HR controlled complex (cardio and resistance) aerobic training effectively decreased CV risk factors and strongly improved state of health and quality of life.
C1 [Joe, J. G.] Univ Pannonia, Veszprem, Hungary.
   [Dosa, A.] Csolnoky Ferenc Hosp, Diabet & Metab Ctr, Veszprem, Hungary.
   [Ranky, M.] Eotvos Lorand Univ, Fac Educ & Psychol, Inst Hlth Promot & Sport Sci, Budapest, Hungary.
   [Pavlik, G.] Semmelweis Univ, Fac Phys Educ & Sports Sci, H-1085 Budapest, Hungary.
C3 University of Pannonia; Eotvos Lorand University; Semmelweis University
RP Joé, JG (corresponding author), Sorompo U 18, H-8200 Veszprem, Hungary.
EM noejudit@chello.hu
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NR 38
TC 2
Z9 2
U1 0
U2 6
PU AKADEMIAI KIADO ZRT
PI BUDAPEST
PA BUDAFOKI UT 187-189-A-3, H-1117 BUDAPEST, HUNGARY
SN 0231-424X
EI 1588-2683
J9 ACTA PHYSIOL HUNG
JI Acta Physiol. Hung.
PD MAR
PY 2014
VL 101
IS 1
BP 1
EP 12
DI 10.1556/APhysiol.101.2014.1.1
PG 12
WE Science Citation Index Expanded (SCI-EXPANDED)
GA AD0TG
UT WOS:000332946400001
PM 24631792
DA 2025-06-11
ER

PT J
AU de la Maza, MP
   Olivares, D
   Hirsch, S
   Sierralta, W
   Gattas, V
   Barrera, G
   Bunout, D
   Leiva, L
   Fernández, M
AF de la Maza, Maria-Pia
   Olivares, Daniela
   Hirsch, Sandra
   Sierralta, Walter
   Gattas, Vivien
   Barrera, Gladys
   Bunout, Daniel
   Leiva, Laura
   Fernandez, Mireya
TI Weight increase and overweight are associated with DNA oxidative damage
   in skeletal muscle
SO CLINICAL NUTRITION
LA English
DT Article
DE weight maintenance; overweight; body fat; oxidative injury; 80HdG; 4HNE;
   TNF-alpha
ID NECROSIS-FACTOR-ALPHA; CALORIC RESTRICTION; SARCOPENIC OBESITY;
   METABOLIC SYNDROME; MITOCHONDRIAL-DNA; VISCERAL FAT; STRESS; PREVENTION;
   RESISTANCE; PROTEINS
AB Background and aims: Weight maintenance within normal standards is recommended for prevention of conditions associated with oxidative injury. To compare oxidative damage in a post mitotic tissue, between adults differing in long-term energy balance.
   Methods: During hernia surgery, a sample of skeletal muscle was obtained in 17 non-obese adults. Subjects were divided into two groups according to their self-reported weight change: weight maintainers (WM) reported < 4kg increase, and weight gainers (WG) reported > 5 kg increment. Muscle immunohistochemistry for 8-hydroxy-deoxyguanosine (80HdG), 4-Hydroxy-2-nonenal (4HNE), and TNF-alpha, as markers of oxidative injury and inflammation, were performed. As known positive controls for oxidative injury, we included 10 elderly subjects (66-101 yr). Anthropometric measures and blood samples for clinical laboratory and serum cytokines (TNF-alpha and IL-6) were obtained.
   Results: 80HdG was higher in WG compared with WM (149.1 +/- 16.2 versus 117.8 +/- 29.5, P = 0.03), and was associated with anthropometric indicators of fat accumulation. 4HNE was similar in WG compared with WM (10.9 +/- 7.6 versus 9.8 +/- 6.3) but noticeably higher in elderly subjects (21.5 +/- 15.3, P = 0.059). TNF-alpha protein in WG was higher compared with WM (114.0 +/- 41.7 versus 70.1 +/- 23.3, P = 0.025), and was associated with weight increase.
   Conclusions: Moderate self-reported weight increase, and body fat accumulation, suggesting long-term positive energy balance is associated with muscle DNA oxidative injury and inflammation. (c) 2006 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.
C1 Univ Chile, Inst Nutr & Food Technol, INTA, Santiago, Chile.
C3 Universidad de Chile
RP de la Maza, MP (corresponding author), Univ Chile, Inst Nutr & Food Technol, INTA, Macul 5540,POB 138-11, Santiago, Chile.
RI Hirsch, Sandra/R-2431-2016
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NR 43
TC 14
Z9 16
U1 0
U2 7
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0261-5614
EI 1532-1983
J9 CLIN NUTR
JI Clin. Nutr.
PD DEC
PY 2006
VL 25
IS 6
BP 968
EP 976
DI 10.1016/j.clnu.2006.02.008
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 123AJ
UT WOS:000243268400012
PM 16687193
DA 2025-06-11
ER

PT J
AU Magenis, ML
   Damiani, AP
   Monteiro, ID
   Dagostin, LS
   Silva, ND
   Scussel, R
   Nagashima, S
   Langie, SAS
   Pinho, RA
   de Andrade, VM
AF Magenis, Marina Lummertz
   Damiani, Adriani Paganini
   Monteiro, Isadora de Oliveira
   Dagostin, Ligia Salvan
   Silva, Nicollas dos Santos
   Scussel, Rahisa
   Nagashima, Seigo
   Langie, Sabine A. S.
   Pinho, Ricardo Aurino
   de Andrade, Vanessa Moraes
TI Maternal exercise during pregnancy modulates genotoxicity caused by high
   fructose consumption in mice offspring
SO MUTAGENESIS
LA English
DT Article
DE foetal programming; fructose; physical exercise; genotoxicity;
   mutagenicity
ID DEVELOPMENTAL ORIGINS; DNA-DAMAGE; CORN SYRUP; MONOSODIUM GLUTAMATE;
   RESISTANCE EXERCISE; MICRONUCLEUS ASSAY; INSULIN-RESISTANCE; METABOLIC
   SYNDROME; OXIDATIVE STRESS; BODY-COMPOSITION
AB Pregnancy is a period that is characterized by several metabolic and physiological changes and requires special attention, especially with regard to the relationship between feeding and foetal development. Therefore, the objective of this study was to evaluate whether the practice of voluntary physical exercise (VPE) in combination with chronic consumption of fructose (FRU) from the beginning of life and/or until the gestational period causes genotoxic changes in pregnant females and in their offspring. Seventy Swiss female mice received FRU in the hydration bottle and/or practiced VPE for 8 weeks (prepregnancy/pregnancy). After the lactation period, the offspring groups were separated by sex. It was observed that the consumption of FRU affected the food consumption, serum concentration of FRU, and glycemic profile in the mothers and that the VPE decreases these parameters. In addition, FRU was genotoxic in the mothers' peripheral tissues and VPE had a preventive effect on these parameters. The offspring showed changes in food consumption, serum FRU concentration, and body weight, in addition to an increase in the adiposity index in male offspring in the FRU (FRU) group and a decrease in the FRU + VPE group. FRU leads to hepatic steatosis in the offspring and VPE was able to decrease the area of steatosis. In addition, FRU led to genotoxicity in the offspring and VPE was able to modulate this effect, reducing damages. In conclusion, we observed that all interventions with VPE had nutritional, genetic, and biochemical benefits of the mother and her offspring.
C1 [Magenis, Marina Lummertz; Damiani, Adriani Paganini; Monteiro, Isadora de Oliveira; Dagostin, Ligia Salvan; Silva, Nicollas dos Santos; de Andrade, Vanessa Moraes] Univ Southern Santa Catarina UNESC, Grad Program Hlth Sci, Lab Translat Biomed, Criciuma, SC, Brazil.
   [Scussel, Rahisa] Univ Southern Santa Catarina UNESC, Grad Program Hlth Sci, Lab Expt Pathophysiol, Criciuma, SC, Brazil.
   [Nagashima, Seigo] Pontif Catholic Univ Parana PUCPR, Lab Expt Pathol, Parana, SC, Brazil.
   [Langie, Sabine A. S.] Maastricht Univ, Sch Nutr & Translat Res Metab NUTRIM, Dept Pharmacol & Toxicol, Maastricht, Netherlands.
   [Pinho, Ricardo Aurino] Pontif Catholic Univ Parana PUCPR, Lab Biochem Exercise Hlth, Parana, SC, Brazil.
   [de Andrade, Vanessa Moraes] Univ Southern Santa Catarina, Dept Hlth Sci, Grad Program Hlth Sci, Lab Translat Biomed,UNESC, 1105 Univ Rd, BR-88806000 Criciuma, SC, Brazil.
C3 Universidade do Sul de Santa Catarina; Universidade do Sul de Santa
   Catarina; Maastricht University; Universidade do Sul de Santa Catarina
RP de Andrade, VM (corresponding author), Univ Southern Santa Catarina, Dept Hlth Sci, Grad Program Hlth Sci, Lab Translat Biomed,UNESC, 1105 Univ Rd, BR-88806000 Criciuma, SC, Brazil.
EM vmoraesdeandrade@yahoo.com.br
RI Andrade, Vanessa/F-9623-2012; Damiani, Adriani/N-8007-2018; Monteiro,
   Isadora/MVV-9472-2025; A. Pinho, Ricardo/G-2643-2012; Langie,
   Sabine/Q-2917-2017; Scussel, Rahisa/HPD-5322-2023
OI A. Pinho, Ricardo/0000-0003-3116-4553; Langie,
   Sabine/0000-0003-3288-7331; Scussel, Rahisa/0000-0002-0931-604X
FU Graduate Program in Health Sciences; Coordination for the Improvement of
   Higher Education Personnel (CAPES); National Council of Technological
   and Scientific Development [CNPq-304203/2018-1]; Santa Catarina Research
   and Innovation Support Foundation (FAPESC); University of Southern Santa
   Catarina (UNESC)
FX The authors would also like to thank the Graduate Program in Health
   Sciences (PPGCS); Coordination for the Improvement of Higher Education
   Personnel (CAPES); National Council of Technological and Scientific
   Development (CNPq-304203/2018-1); Santa Catarina Research and Innovation
   Support Foundation (FAPESC); and the University of Southern Santa
   Catarina (UNESC).
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TC 3
Z9 3
U1 0
U2 0
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0267-8357
EI 1464-3804
J9 MUTAGENESIS
JI Mutagenesis
PD MAR 12
PY 2024
VL 39
IS 2
BP 119
EP 140
DI 10.1093/mutage/gead035
EA DEC 2023
PG 22
WC Genetics & Heredity; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Genetics & Heredity; Toxicology
GA KU8J1
UT WOS:001125778300001
PM 38019677
DA 2025-06-11
ER

PT J
AU Escalante-Aburto, A
   Mendoza-Córdova, MY
   Mahady, GB
   Luna-Vital, DA
   Gutiérrez-Uribe, JA
   Chuck-Hernández, C
AF Escalante-Aburto, Anayansi
   Mendoza-Cordova, Mayra Yesenia
   Mahady, Gail B.
   Luna-Vital, Diego A.
   Gutierrez-Uribe, Janet A.
   Chuck-Hernandez, Cristina
TI Consumption of dietary anthocyanins and their association with a
   reduction in obesity biomarkers and the prevention of obesity
SO TRENDS IN FOOD SCIENCE & TECHNOLOGY
LA English
DT Article
DE Anthocyanins; Glycosylated anthocyanins; Obesity; Weight gain;
   Inflammation; Transcriptional factors
ID METABOLIC SYNDROME; OXIDATIVE STRESS; KAPPA-B; INFLAMMATION; EXTRACT;
   ADIPOCYTES; EXPRESSION; ONIONS; FRUITS; MCP-1
AB Background: The emergency for treating obesity has increased, triggering severe economic issues worldwide. The consumption of anthocyanins from different dietetic sources or by pharmaceutical prescription has shown strong associations with ameliorating specific physiological biomarkers and genetic factors related to obesity. Scope and approach: This review focuses on examining and contrasting the findings from the past five years regarding the precise effects of anthocyanin compounds on metabolic health. These effects were evaluated primarily in in vivo models, assessed before and after consumption of various anthocyanin compounds from fresh foods, food extracts, and supplemental products. Descriptions of a few elements connected to, among others, adipose tissue, vascular endothelium, systemic pro-inflammatory state, and obesity biomarkers are reviewed. Key finds and conclusions: Clinical trials in subjects with overweight and obesity and essays in murine obesity induced models have reported promising findings concerning anthocyanins consumption, specifically cyanidin-3-O-glucoside ingestion. The main effects in physiological biomarkers and indicators of anthocyanins consumption are a significant reduction of body weight and fat mass (brown adipocytes), triglycerides, cholesterol (LDL and VLDL), insulin resistance (HOMA) and a decrease of inflammation biomarkers such as IL-6, IL-10, and TNF-& alpha;, promoting the AMPK and MAPK pathways and regulating genes related to adipogenesis (PPAR-& gamma;, GPx1, ACAT3, COX2, UCP1, and IL1 & beta;). There is a lack of studies on human subjects with obesity to corroborate the beneficial effects of anthocyanins (by diet or prescribed). It is necessary to discuss the food policies and nutritional advice regulations for incentivizing anthocyanin ingestion as a therapeutic effect against obesity.
C1 [Escalante-Aburto, Anayansi; Mendoza-Cordova, Mayra Yesenia; Luna-Vital, Diego A.; Gutierrez-Uribe, Janet A.; Chuck-Hernandez, Cristina] Tecnol Monterrey, Inst Obes Res, Eugenio Garza Sada 2501, Monterrey 64849, Nuevo Leon, Mexico.
   [Mahady, Gail B.] Univ Illinois, Coll Pharm, Dept Pharm Practice, World Hlth Org Collaborating Ctr Tradit Med, Chicago, IL USA.
C3 Tecnologico de Monterrey; World Health Organization; University of
   Illinois System; University of Illinois Chicago; University of Illinois
   Chicago Hospital
RP Chuck-Hernández, C (corresponding author), Tecnol Monterrey, Inst Obes Res, Eugenio Garza Sada 2501, Monterrey 64849, Nuevo Leon, Mexico.
EM cristina.chuck@tec.mx
RI Gutiérrez-Uribe, Janet/Q-5375-2019; Escalante-Aburto,
   Anayansi/Y-4717-2019; Luna-Vital, Diego/B-9634-2015; Chuck,
   Cristina/AFP-7287-2022
OI Escalante-Aburto, Anayansi/0000-0002-6781-5154
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NR 104
TC 27
Z9 27
U1 6
U2 28
PU ELSEVIER SCIENCE LONDON
PI LONDON
PA 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND
SN 0924-2244
EI 1879-3053
J9 TRENDS FOOD SCI TECH
JI Trends Food Sci. Technol.
PD OCT
PY 2023
VL 140
AR 104140
DI 10.1016/j.tifs.2023.104140
EA AUG 2023
PG 15
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA S2NK3
UT WOS:001069586900001
OA hybrid
DA 2025-06-11
ER

PT J
AU Mahmoodi, MR
   Abbasi, MM
AF Mahmoodi, Mohammad Reza
   Abbasi, Mohammad Mehdi
TI Therapeutic Effectiveness of Sesame Preparations and its Bioactive
   Ingredients in Management of Cardiometabolic Syndrome in Diabetes
   Mellitus: A Systematic Review
SO CURRENT DIABETES REVIEWS
LA English
DT Review
DE Sesame preparations; bioactive ingredients; cardiometabolic syndrome;
   therapeutic effectiveness; diabetic patients; coronary artery disease
ID CORONARY-ARTERY-DISEASE; LIPID-PEROXIDATION; OXIDATIVE STRESS;
   BLOOD-GLUCOSE; CANOLA OILS; INDICUM L.; RATS; SEED; PARAMETERS; MARKERS
AB Aim This systematic review aimed to appraise and recapitulate all research investigations to elucidate the effects of Sesamum indicum preparations on managing the cardiometabolic syndrome of Diabetes mellitus (DM) and metabolic syndrome (MetS). Methods A systematic review was carried out in a Cochrane fashion and in compliance with the PRISMA checklist using the published academic works in PubMed/MEDLINE, WOS, SCOPUS, and EMBASE databases that were searched up to June 2021. Abstracts that met PICO criteria for qualitative studies were duplicate reviewed for data extraction to assess the quality and details of the study. Results Sesamum indicum preparations and its bioactive lignans, such as sesamin, sesamol, and pinoresinol, were found to possess anti-hyperglycemic, anti-hyperlipidemia, anti-inflammatory, antioxidative, anti-hypertensive, cardioprotective, and hepatoprotective effects both in patients with T2DM as well as in experimental animal models with T1DM and MetS. The incorporation of sesame oil as a natural adjuvant can be effective in improving vascular reactivity and aortic permeability, reproductive parameters, and diabetic nephropathy, as well as modification of anthropometry indices. Therefore, sesame oil and bioactive lignans as combination therapy with drugs can exhibit synergistic effects and provide a favorable preference in clinical settings. Conclusion Sesame oil and lignans present in it act in a dose-dependent manner. The best dosage to improve risk biomarkers of patients with T2DM and MetS is 30-35 ml daily of sesame oil or inclusion of sesame oil in daily dietary patterns up to 30% of total energy for 8-12 weeks and/or 200 mg daily of sesamin supplementation for eight weeks.
C1 [Mahmoodi, Mohammad Reza] Kerman Univ Med Sci, Inst Neuropharmacol, Physiol Res Ctr, Dept Nutr, Kerman, Iran.
   [Mahmoodi, Mohammad Reza; Abbasi, Mohammad Mehdi] Kerman Univ Med Sci, Fac Publ Hlth, Dept Nutr, Kerman, Iran.
C3 Kerman University of Medical Sciences; Kerman University of Medical
   Sciences
RP Mahmoodi, MR (corresponding author), Kerman Univ Med Sci, Inst Neuropharmacol, Physiol Res Ctr, Dept Nutr, Kerman, Iran.; Mahmoodi, MR (corresponding author), Kerman Univ Med Sci, Fac Publ Hlth, Dept Nutr, Kerman, Iran.
EM mahmoodimr@yahoo.com
RI Mahmoodi, Mohammad Reza/ITT-0506-2023
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NR 64
TC 2
Z9 2
U1 0
U2 5
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1573-3998
EI 1875-6417
J9 CURR DIABETES REV
JI Curr. Diabetes Reviews
PY 2023
VL 19
IS 3
AR E250522205240
DI 10.2174/1573399818666220525110925
PG 15
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA I8WY0
UT WOS:001005543100001
PM 35619269
DA 2025-06-11
ER

PT J
AU Molina-Molina, E
   Furtado, GE
   Jones, JG
   Portincasa, P
   Vieira-Pedrosa, A
   Teixeira, AM
   Barros, MP
   Bachi, ALL
   Sardao, VA
AF Molina-Molina, Emilio
   Furtado, Guilherme Eustaquio.
   Jones, John G.
   Portincasa, Piero
   Vieira-Pedrosa, Ana
   Teixeira, Ana Maria
   Barros, Marcelo Paes
   Bachi, Andre Luis Lacerda
   Sardao, Vilma A.
TI The advantages of physical exercise as a preventive strategy against
   NAFLD in postmenopausal women
SO EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
LA English
DT Review
DE ageing; menopause; metabolic dysfunction-associated fatty liver disease
   (MAFLD); nonalcoholic fatty liver disease (NAFLD); oestradiol; physical
   activity
ID NONALCOHOLIC FATTY LIVER; HORMONE REPLACEMENT THERAPY; QUALITY-OF-LIFE;
   ADIPOSE-TISSUE; INSULIN-RESISTANCE; NATURAL-HISTORY; AEROBIC EXERCISE;
   SKELETAL-MUSCLE; GENE-EXPRESSION; UNITED-STATES
AB Background The prevalence and severity of nonalcoholic fatty liver disease (NAFLD) increase in women after menopause. This narrative review discusses the causes and consequences of NAFLD in postmenopausal women and describes how physical activity can contribute to its prevention. Methods The authors followed the narrative review method to perform a critical and objective analysis of the current knowledge on the topic. The Medical Subject Heading keywords 'physical exercise', 'menopause', 'hormone replacement therapy', 'estradiol' and 'NAFLD' were used to establish a conceptual framework. The databases used to collect relevant references included Medline and specialized high-impact journals. Results Higher visceral adiposity, higher rate of lipolysis in adipose tissue after oestrogen drop and changes in the expression of housekeeping proteins involved in hepatic lipid management are observed in women after menopause, contributing to NAFLD. Excessive liver steatosis leads to hepatic insulin resistance, oxidative stress and inflammation, accelerating NAFLD progression. Physical activity brings beneficial effects against several postmenopausal-associated complications, including NAFLD progression. Aerobic and resistance exercises partially counteract alterations induced by metabolic syndrome in sedentary postmenopausal women, impacting NAFLD progression and severity. Conclusions With the increased global obesity epidemic in developing countries, NAFLD is becoming a severe problem with increased prevalence in women after menopause. Evidence shows that physical activity may delay NAFLD development and severity in postmenopausal women, although the prescription of age-appropriate physical activity programmes is advisable to assure the health benefits.
C1 [Molina-Molina, Emilio; Portincasa, Piero] Univ Bari Med Sch, Clin Med A Murri, Dept Biomed Sci & Human Oncol, Bari, Italy.
   [Furtado, Guilherme Eustaquio.] Nursing Sch Coimbra ESEnfC, Hlth Sci Res Unit Nursing UICISA E, Coimbra, Portugal.
   [Furtado, Guilherme Eustaquio.; Vieira-Pedrosa, Ana; Teixeira, Ana Maria] Univ Coimbra, Fac Sport Sci & Phys Educ, Res Unit Sport & Phys Act CIDAF, FCDEF UC, Coimbra, Portugal.
   [Jones, John G.; Sardao, Vilma A.] Univ Coimbra, CIBB, CNC Ctr Neurosci & Cell Biol, Coimbra, Portugal.
   [Barros, Marcelo Paes] Univ Cruzeiro Sul, Interdisciplinary Program Hlth Sci, Inst Phys Act Sci & Sports ICAFE, Sao Paulo, Brazil.
   [Bachi, Andre Luis Lacerda] Brazilian Inst Teaching & Res Pulm & Exercise Imm, Sao Paulo, Brazil.
   [Bachi, Andre Luis Lacerda] Fed Univ Sao Paulo UNIFESP, ENT Lab, Dept Otorhinolaryngol, Sao Paulo, Brazil.
   [Bachi, Andre Luis Lacerda] Santo Amaro Univ UNISA, Postgrad Program Hlth Sci, Sao Paulo, Brazil.
   Univ Coimbra, Fac Sport Sci & Phys Educ, Coimbra, Portugal.
C3 Universita degli Studi di Bari Aldo Moro; Nursing School of Coimbra;
   Universidade de Coimbra; Universidade de Coimbra; Universidade Cruzeiro
   do Sul; Universidade Federal de Sao Paulo (UNIFESP); Universidade de
   Santo Amaro (UNISA); Universidade de Coimbra
RP Sardao, VA (corresponding author), Univ Coimbra, CNC Ctr Neurosci & Cell Biol, UC Biotech Bldg,Biocant Pk, P-3060197 Cantanhede, Portugal.
EM vimarisa@cnc.uc.pt
RI portincasa, piero/J-7245-2018; Jones, John/A-8684-2010; Sardao,
   Vilma/A-1546-2012; Luis Lacerda Bachi, Andre/G-2946-2012; Furtado,
   Guilherme Eustaquio/AAR-1200-2020; Teixeira, Ana/O-3427-2018; Paes de
   Barros, Marcelo/K-1410-2013
OI Pedrosa, Ana/0000-0001-5366-858X; Sardao, Vilma/0000-0001-7014-4614;
   Luis Lacerda Bachi, Andre/0000-0001-8266-1416; Jones,
   John/0000-0002-3745-3885; portincasa, piero/0000-0001-5359-1471;
   Furtado, Guilherme Eustaquio/0000-0001-8327-1567; Molina Molina,
   Emilio/0000-0003-4390-5275; Teixeira, Ana/0000-0003-1498-949X; Paes de
   Barros, Marcelo/0000-0003-3565-8331
FU European Union [722619]; Fundacao para a Ciencia e a Tecnologia
   [UIDB/04539/2020, UIDP/04539/2020, UID/PTD/04213/2020]; FCT Investigator
   program [IF/01182/2015]; Brazilian National Council for Scientific and
   Technology Development [305818/2018-0, 307674/2017-7]
FX European Union's Horizon 2020 Research; Innovation programme under the
   Marie Sklodowska-Curie, Grant/Award Number: 722619; Fundacao para a
   Ciencia e a Tecnologia, Grant/Award Number: UIDB/04539/2020,
   UIDP/04539/2020 and UID/PTD/04213/2020; FCT Investigator program,
   Grant/Award Number: IF/01182/2015; Brazilian National Council for
   Scientific and Technology Development, Grant/Award Number: PQ-2
   #305818/2018-0 and PQ-2 #307674/2017-7
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NR 201
TC 11
Z9 11
U1 1
U2 23
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0014-2972
EI 1365-2362
J9 EUR J CLIN INVEST
JI Eur. J. Clin. Invest.
PD MAR
PY 2022
VL 52
IS 3
SI SI
AR e13731
DI 10.1111/eci.13731
EA JAN 2022
PG 20
WC Medicine, General & Internal; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Research & Experimental Medicine
GA YY0CT
UT WOS:000739320500001
PM 34890043
DA 2025-06-11
ER

PT J
AU Szweda-Gandor, N
   Snit, M
   Grzeszczak, W
AF Szweda-Gandor, Nikola
   Snit, Miroslaw
   Grzeszczak, Wladyslaw
TI Association between Selected Polymorphisms rs12086634, rs846910,
   rs4844880, rs3753519 of 11β-Hydroxysteroid Dehydrogenase Type 1
   (HSD11B1) and the Presence of Insulin Resistance in the Polish
   Population of People Living in Upper Silesia
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Article
DE selected polymorphism; HSD11B1; insulin resistance
ID BODY-FAT DISTRIBUTION; METABOLIC SYNDROME; GENE POLYMORPHISMS;
   11-BETA-HSD1; INHIBITION; EXPRESSION; VARIANTS; CORTISOL; OBESITY;
   TRAITS
AB Background: Many factors influence the development of insulin resistance, among other genetic factors. Cortisol is one of the factors that has a significant impact on the development of insulin resistance. The proteins that have a substantial effect on blood cortisol levels include 11 beta-hydroxysteroid dehydrogenase type 1. HSD11B1 is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. Gene encoding HSD11B1 is located on 1q32.2. This study was designed to assess the association between four polymorphic sides in HSD11B1 (rs12086634, rs846910, rs4844880, rs3753519) between subjects with and without insulin resistance in the Polish population of people living in Upper Silesia. Methods: The study included a total of 507 consecutive patients, 374 (73.77%) with and 133 (26.23%) without insulin resistance. Results: The results show that there were no statistically significant differences in the distribution of genotypes and alleles of the examined polymorphisms of the 11 beta-hydroxysteroid dehydrogenase type 1 gene between subjects with and without insulin resistance (determined using the HOMA-IR, insulin resistance index) and that rs846910 and rs1208663 polymorphisms of the 11 beta-hydroxysteroid dehydrogenase type 1 gene in the examined subjects have a significant effect on the magnitude of the HOMA-IR insulin resistance index. Conclusions: The study results suggested that genetic variation of rs846910 and rs1208663 polymorphism of the HSD11B1 gene is related to the susceptibility to insulin resistance. Our results provide a basis to begin basic research on the role of the HSD11B1 gene in the pathogenesis of insulin resistance.
C1 [Szweda-Gandor, Nikola; Snit, Miroslaw; Grzeszczak, Wladyslaw] Med Univ Silesia, Fac Med Sci Zabrze, Dept Internal Med Diabetol & Nephrol, PL-40155 Katowice, Poland.
C3 Medical University of Silesia
RP Grzeszczak, W (corresponding author), Med Univ Silesia, Fac Med Sci Zabrze, Dept Internal Med Diabetol & Nephrol, PL-40155 Katowice, Poland.
EM nszweda@sum.edu.pl; msnit@sum.edu.pl; wgrzeszczak@sum.edu.pl
OI Szweda-Gandor, Nikola/0000-0002-3571-8587
FU Medical University of Silesia [KNW-2-K21/D/7/N]
FX Grant Medical University of Silesia no. KNW-2-K21/D/7/N.
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NR 30
TC 1
Z9 1
U1 0
U2 2
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD OCT
PY 2021
VL 18
IS 19
AR 10168
DI 10.3390/ijerph181910168
PG 9
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA WV9GL
UT WOS:000717537300001
PM 34639470
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Prabhu, YD
   Gopalakrishnan, AV
AF Prabhu, Yogamaya D.
   Gopalakrishnan, Abilash Valsala
TI Can polyunsaturated fatty acids regulate Polycystic Ovary Syndrome via
   TGF-β signalling?
SO LIFE SCIENCES
LA English
DT Review
DE Polycystic Ovary Syndrome; Polyunsaturated fatty acids; Therapeutic;
   Inflammation; Infertility; Transforming Growth Factor-?
ID C-REACTIVE PROTEIN; GROWTH-FACTOR-BETA; NECROSIS-FACTOR-ALPHA;
   GAMMA-LINOLENIC ACID; OXIDATIVE STRESS; METABOLIC SYNDROME;
   ADIPOSE-TISSUE; SYNDROME PCOS; CARDIOVASCULAR-DISEASE;
   INSULIN-RESISTANCE
AB Polycystic Ovary Syndrome (PCOS) is a metabolic condition that affects women in their reproductive age by altering the ovarian hormone levels, leading to infertility. Increased inflammation, insulin resistance, hyperandrogenism, irregular menses, and infertility are the causes of morbidity when PCOS is the disease in question. PCOS is considered a multifactorial disease resulting from the disruption of multiple signalling pathways. Hence, the mono-targeted drugs are hardly adequate and conventional therapeutic strategies provide only palliative care. Studies show that the consumption of polyunsaturated fatty acids (PUFAs) regulates menstrual cycle, decrease testosterone and insulin levels, and improve metabolic health. This could favourably affect diabetes and infertility. In recent years, the fibrillin-3 gene has been linked to PCOS. Fibrillins along with the molecules in the extracellular matrix modulate the Transforming Growth Factor-? (TGF-?) signalling. So, mutations in the fibrillin-3 gene could cause TGF-? dysregulation, which might further contribute to PCOS pathogenesis. Therefore, the current study aimed to understand whether PUFAs could manage PCOS via the TGF-? pathway and function as a therapeutic agent for PCOS and its complications. To understand this, we have focused on the involvement of TGF-? in PCOS pathogenesis, discussed the effect of PUFA on hormones, insulin resistance, inflammation, obesity, adiponectin, and cardiovascular conditions. Using PUFAs to target TGF-? or its receptor molecules to modulate the TGF-? production might function as a treatment option for PCOS. PUFA therapy could be a good alternative, supportive medication for PCOS.
C1 [Prabhu, Yogamaya D.; Gopalakrishnan, Abilash Valsala] Vellore Inst Technol VIT, Sch Bio Sci & Technol, Dept Biomed Sci, Vellore 632014, Tamil Nadu, India.
C3 Vellore Institute of Technology (VIT); VIT Vellore
RP Gopalakrishnan, AV (corresponding author), Vellore Inst Technol VIT, Sch Bio Sci & Technol, Dept Biomed Sci, Vellore 632014, Tamil Nadu, India.
EM abilash.vg@vit.ac.in
RI Valsala Gopalakrishnan, Abilash/C-1482-2019
OI Valsala Gopalakrishnan, Abilash/0000-0003-0780-0492
FU VIT; ICMR National Task Force Project [5/7/482/2010-RBMHCH]
FX The authors thank VIT for providing "VIT SEED GRANT" and ICMR National
   Task Force Project [F.No.5/7/482/2010-RBMH&CH] for carrying out this
   work.
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NR 129
TC 7
Z9 9
U1 3
U2 14
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0024-3205
EI 1879-0631
J9 LIFE SCI
JI Life Sci.
PD JUL 1
PY 2021
VL 276
AR 119416
DI 10.1016/j.lfs.2021.119416
EA APR 2021
PG 9
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA RY1WU
UT WOS:000647710200009
PM 33774033
DA 2025-06-11
ER

PT J
AU Aghili, SMM
   Ebrahimpur, M
   Arjmand, B
   Shadman, Z
   Sani, MP
   Qorbani, M
   Larijani, B
   Payab, M
AF Aghili, Seyed Morsal Mosallami
   Ebrahimpur, Mahbube
   Arjmand, Babak
   Shadman, Zhaleh
   Sani, Mahnaz Pejman
   Qorbani, Mostafa
   Larijani, Bagher
   Payab, Moloud
TI Obesity in COVID-19 era, implications for mechanisms, comorbidities, and
   prognosis: a review and meta-analysis
SO INTERNATIONAL JOURNAL OF OBESITY
LA English
DT Review
ID INFLUENZA A(H1N1) INFECTION; METABOLIC SYNDROME; DISEASE;
   HOSPITALIZATION; INFLAMMATION; MORTALITY; OUTCOMES; DEATH; MICE
AB Background Recent studies have shown that obesity is associated with the severity of coronavirus disease (COVID-19). We reviewed clinical studies to clarify the obesity relationship with COVID-19 severity, comorbidities, and discussing possible mechanisms. Materials and methods The electronic databases, including Web of Science, PubMed, Scopus, and Google Scholar, were searched and all studies conducted on COVID-19 and obesity were reviewed. All studies were independently screened by reviewers based on their titles and abstracts. Results Forty relevant articles were selected, and their full texts were reviewed. Obesity affects the respiratory and immune systems through various mechanisms. Cytokine and adipokine secretion from adipose tissue leads to a pro-inflammatory state in obese patients, predisposing them to thrombosis, incoordination of innate and adaptive immune responses, inadequate antibody response, and cytokine storm. Obese patients had a longer virus shedding. Obesity is associated with other comorbidities such as hypertension, cardiovascular diseases, diabetes mellitus, and vitamin D deficiency. Hospitalization, intensive care unit admission, mechanical ventilation, and even mortality in obese patients were higher than normal-weight patients. Obesity could alter the direction of severe COVID-19 symptoms to younger individuals. Reduced physical activity, unhealthy eating habits and, more stress and fear experienced during the COVID-19 pandemic may result in more weight gain and obesity. Conclusions Obesity should be considered as an independent risk factor for the severity of COVID-19. Paying more attention to preventing weight gain in obese patients with COVID-19 infection in early levels of disease is crucial during this pandemic.
C1 [Aghili, Seyed Morsal Mosallami; Sani, Mahnaz Pejman; Larijani, Bagher] Univ Tehran Med Sci, Endocrinol & Metab Res Ctr, Endocrinol & Metab Clin Sci Inst, Tehran, Iran.
   [Ebrahimpur, Mahbube; Shadman, Zhaleh] Univ Tehran Med Sci, Elderly Hlth Res Ctr, Endocrinol & Metab Populat Sci Inst, Tehran, Iran.
   [Arjmand, Babak] Univ Tehran Med Sci, Cell Therapy & Regenerat Med Res Ctr, Endocrinol & Metab Mol Cellular Sci Inst, Tehran, Iran.
   [Arjmand, Babak; Payab, Moloud] Univ Tehran Med Sci, Metabol & Genom Res Ctr, Endocrinol & Metab Mol Cellular Sci Inst, Tehran, Iran.
   [Qorbani, Mostafa] Alborz Univ Med Sci, Noncommunicable Dis Res Ctr, Karaj, Iran.
C3 Tehran University of Medical Sciences; Tehran University of Medical
   Sciences; Tehran University of Medical Sciences; Tehran University of
   Medical Sciences; Alborz University of Medical Sciences
RP Ebrahimpur, M (corresponding author), Univ Tehran Med Sci, Elderly Hlth Res Ctr, Endocrinol & Metab Populat Sci Inst, Tehran, Iran.; Payab, M (corresponding author), Univ Tehran Med Sci, Metabol & Genom Res Ctr, Endocrinol & Metab Mol Cellular Sci Inst, Tehran, Iran.
EM m-ebrahimpur@tums.ac.ir; moloudpayab@gmail.com
RI larijani, Bagher/ABE-3315-2020; sani, mahnaz/AAS-9271-2020; Arjmand,
   babak/AAS-3830-2020; , Mahbube/AAK-3728-2020; Qorbani,
   Mostafa/M-8171-2017; Mosallami Aghili, Seyed Morsal/KMY-8176-2024
OI Larijani, Bagher/0000-0001-5386-7597; Mosallami Aghili, Seyed
   Morsal/0000-0002-7372-0143
FU Tehran University of Medical Sciences (Endocrinology and Metabolism
   Research Center)
FX Implementation of this study was sponsored by Tehran University of
   Medical Sciences (Endocrinology and Metabolism Research Center).
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NR 132
TC 126
Z9 127
U1 3
U2 25
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0307-0565
EI 1476-5497
J9 INT J OBESITY
JI Int. J. Obes.
PD MAY
PY 2021
VL 45
IS 5
BP 998
EP 1016
DI 10.1038/s41366-021-00776-8
EA FEB 2021
PG 19
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA RU6IL
UT WOS:000622229200007
PM 33637951
OA Green Published
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Emamat, H
   Asadian, S
   Zahedmehr, A
   Ghanavati, M
   Nasrollahzadeh, J
AF Emamat, Hadi
   Asadian, Sanaz
   Zahedmehr, Ali
   Ghanavati, Matin
   Nasrollahzadeh, Javad
TI The effect of barberry (Berberis vulgaris) consumption on
   flow-mediated dilation and inflammatory biomarkers in patients with
   hypertension: A randomized controlled trial
SO PHYTOTHERAPY RESEARCH
LA English
DT Article
DE barberry; Berberis vulgaris; flow&#8208; mediated dilation; FMD;
   hypertension; inflammation
ID C-REACTIVE PROTEIN; ENDOTHELIAL FUNCTION; DOUBLE-BLIND; METABOLIC
   SYNDROME; OXIDATIVE STRESS; BLOOD-PRESSURE; THERAPEUTIC TARGETS;
   ARTERIAL STIFFNESS; ANTIOXIDANT; DYSFUNCTION
AB Hypertension is considered as an important cardiovascular risk factor and evidence suggests that hypertension and endothelial dysfunction reinforce each other. Polyphenol-rich foods, such as barberry can reduce the risk of cardiovascular disease. Our aim was to investigate the effects of barberry consumption on vascular function and inflammatory markers in hypertensive subject. In this randomized controlled parallel trial, 84 hypertensive subjects of both genders (aged 54.06 +/- 10.19 years; body mass index 28.02 +/- 2.18 kg/m(2)) were randomly allocated to consume barberry (10 g/day dried barberry) or placebo for 8 weeks. Before and after the intervention, changes in brachial flow-mediated dilation (FMD) and plasma macrophage/monocyte chemo-attractant protein-1 (MCP-1), vascular cellular adhesion molecule-1, and intracellular adhesion molecule-1 (ICAM-1) were measured. An intention-to-treat analysis was performed. Compared to placebo (n = 42), barberry consumption (n = 42) improved FMD (B [95% CI] was 6.54% [4.39, 8.70]; p < .001) and decreased plasma ICAM-1 (B [95% CI] was -1.61 ng/ml [-2.74, -0.48]; p = .006). MCP-1 was significantly lower in the barberry group compared with the placebo group (B [95% CI] was -37.62 pg/ml [-72.07, -3.17]; p = .033). Our results indicate that barberry consumption improves FMD and has a beneficial effect on plasma ICAM-1 and MCP-1 in hypertensive patients. This trial was registered at the Iranian Registry of Clinical Trial (IRCT) with number IRCT20160702028742N8.
C1 [Emamat, Hadi; Ghanavati, Matin; Nasrollahzadeh, Javad] Shahid Beheshti Univ Med Sci, Fac Nutr Sci & Food Technol, Natl Nutr & Food Technol Res Inst, Dept Clin Nutr & Dietet, PO 19395-4741, Tehran, Iran.
   [Asadian, Sanaz] Shahid Rajaie Cardiovasc Med & Res Ctr, Dept Radiol, Tehran, Iran.
   [Zahedmehr, Ali] Iran Univ Med Sci, Cardiovasc Intervent Res Ctr, Shahid Rajaei Cardiovasc Med & Res Ctr, Tehran, Iran.
C3 Shahid Beheshti University Medical Sciences; Iran University of Medical
   Sciences; Rajaei Cardiovascular Medical & Research Center
RP Nasrollahzadeh, J (corresponding author), Shahid Beheshti Univ Med Sci, Fac Nutr Sci & Food Technol, Natl Nutr & Food Technol Res Inst, Dept Clin Nutr & Dietet, PO 19395-4741, Tehran, Iran.
EM jnasrollahzadeh@gmail.com
RI Nasrollahzadeh, Javad/AIE-5000-2022; Emamat, Hadi/AAJ-7525-2020;
   Asadian, Sanaz/AFA-4552-2022; Ghanavati, Matin/AAD-6617-2022
OI Ghanavati, Matin/0000-0001-7447-3845; Asadian,
   Sanaz/0000-0003-2371-3575; Nasrollahzadeh, Javad/0000-0002-9133-1870;
   Emamat, Hadi/0000-0002-8562-9136; Zahedmehr, Ali/0000-0001-7788-4463
FU National Nutrition and Food Technology Research Institute, Shahid
   Beheshti University of Medical Sciences, Tehran, Iran
FX The study was supported by National Nutrition and Food Technology
   Research Institute, Shahid Beheshti University of Medical Sciences,
   Tehran, Iran. We thank the radiology ward personnel of Shahid Rajaei
   Hospital. We are also grateful to the volunteers who participated in the
   study.
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NR 46
TC 8
Z9 8
U1 2
U2 9
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0951-418X
EI 1099-1573
J9 PHYTOTHER RES
JI Phytother. Res.
PD MAY
PY 2021
VL 35
IS 5
BP 2607
EP 2615
DI 10.1002/ptr.7000
EA DEC 2020
PG 9
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA SG5QV
UT WOS:000600669700001
PM 33350540
DA 2025-06-11
ER

PT J
AU Jin, D
   Zhang, BY
   Li, QL
   Tu, JJ
   Zhou, BH
AF Jin, Dan
   Zhang, Baiyu
   Li, Qiaoling
   Tu, Jingjing
   Zhou, Benhong
TI Effect of punicalagin on multiple targets in streptozotocin/high-fat
   diet-induced diabetic mice
SO FOOD & FUNCTION
LA English
DT Article
ID NF-KAPPA-B; POMEGRANATE JUICE; HEPATIC GLUCONEOGENESIS;
   INSULIN-RESISTANCE; GLYCOGEN-SYNTHESIS; OXIDATIVE STRESS; PI3K/AKT
   PATHWAY; MOUSE MODELS; TYPE-2; METABOLOMICS
AB Type 2 diabetes has a series of metabolic aberrations accompanied by chronic hyperglycemia, along with various comorbidities. In recent reports, punicalagin from pomegranate has been reported to exert hypoglycemic effects against diabetes. The goal of the current research was to investigate the therapeutic effectiveness and elucidate the mechanisms of punicalagin underlying type 2 diabetes. Type 2 diabetes was induced by a high-fat diet (HFD) combined with streptozotocin (STZ) injection in C57BL/6J mice. Punicalagin was administered daily by oral gavage for 4 weeks. The results indicated that high FBG (fasting blood glucose), dyslipidemia and associated islet, liver and kidney injury were observed in the model group mice. Through metabolomics analysis, it was found that the administration of punicalagin could regulate 24 potential biomarkers and their related metabolic pathways. Moreover, the pathological changes in the liver and kidney were mainly mediated by reducing gluconeogenesis and increasing glycogenesis via stimulation of the PI3K/AKT signaling pathway and regulation of the HMGB-1/TLR4/NF-kappa B signaling pathway, which simultaneously interrelated to ten main pathological pathways. In addition, we confirmed the positive role of punicalagin in glucosamine-induced HepG2 cells and HG-induced HK-2 cells through related mechanistic studies in vitro. In conclusion, these findings suggested that the multi-effect and multi-target action mode of punicalagin had a significant hypoglycemic effect and a protective effect on diabetes mellitus. Punicalagin might serve as an alternative functional food or as a clinical supplemental therapy for the diabetic population to ameliorate metabolic syndrome.
C1 [Jin, Dan; Zhang, Baiyu; Zhou, Benhong] Wuhan Univ, Renmin Hosp, Dept Pharm, Wuhan 430060, Hubei, Peoples R China.
   [Li, Qiaoling; Tu, Jingjing; Zhou, Benhong] Wuhan Univ, Sch Pharmaceut Sci, Wuhan 430071, Hubei, Peoples R China.
C3 Wuhan University; Wuhan University
RP Zhou, BH (corresponding author), Wuhan Univ, Renmin Hosp, Dept Pharm, Wuhan 430060, Hubei, Peoples R China.; Zhou, BH (corresponding author), Wuhan Univ, Sch Pharmaceut Sci, Wuhan 430071, Hubei, Peoples R China.
EM benhongzh@whu.edu.cn
RI Jin, Dan/AAJ-2161-2021; zhan, y/ISA-2807-2023; Li,
   Qiaoling/AAQ-2909-2021
OI Zhou, Benhong/0000-0002-6129-0182
FU National Natural Science Foundation of China [31570349]
FX The authors are especially grateful to the skillful technical
   assistance, equipment facilities and experimental sites of the Central
   Laboratory and Animal Room of Renmin Hospital of Wuhan University. This
   work was supported by the National Natural Science Foundation of China
   (no. 31570349).
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PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PD DEC 1
PY 2020
VL 11
IS 12
BP 10617
EP 10634
DI 10.1039/d0fo01275k
PG 18
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA PG8DY
UT WOS:000599960700028
PM 33210684
DA 2025-06-11
ER

PT J
AU Ugalde-Muñiz, P
   Fetter-Pruneda, IA
   Navarro, L
   García, E
   Chavarría, A
AF Ugalde-Muniz, Perla
   Fetter-Pruneda, Ingrid A.
   Navarro, Luz
   Garcia, Esperanza
   Chavarria, Anahi
TI Chronic Systemic Inflammation Exacerbates Neurotoxicity in a Parkinson's
   Disease Model
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Article
ID BLOOD-BRAIN-BARRIER; NITRIC-OXIDE SYNTHASE; NEUROTROPHIC FACTOR;
   OXIDATIVE STRESS; DOPAMINERGIC NEURODEGENERATION; INDUCED
   NEUROINFLAMMATION; MICROGLIAL ACTIVATION; METABOLIC SYNDROME; ALPHA
   KNOCKOUT; PROTEIN-KINASE
AB Systemic inflammation is a crucial factor for microglial activation and neuroinflammation in neurodegeneration. This work is aimed at assessing whether previous exposure to systemic inflammation potentiates neurotoxic damage by the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and how chronic systemic inflammation participates in the physiopathological mechanisms of Parkinson's disease. Two different models of systemic inflammation were employed to explore this hypothesis: a single administration of lipopolysaccharide (sLPS; 5 mg/kg) and chronic exposure to low doses (mLPS; 100 mu g/kg twice a week for three months). After three months, both groups were challenged with MPTP. With the sLPS administration, Iba1 staining increased in the striatum and substantia nigra, and the cell viability lowered in the striatum of these mice. mLPS alone had more impact on the proinflammatory profile of the brain, steadily increasing TNF alpha levels, activating microglia, reducing BDNF, cell viability, and dopamine levels, leading to a damage profile similar to the MPTP model per se. Interestingly, mLPS increased MAO-B activity possibly conferring susceptibility to MPTP damage. mLPS, along with MPTP administration, exacerbated the neurotoxic effect. This effect seemed to be coordinated by microglia since minocycline administration prevented brain TNF alpha increase. Coadministration of sLPS with MPTP only facilitated damage induced by MPTP without significant change in the inflammatory profile. These results indicate that chronic systemic inflammation increased susceptibility to MPTP toxic effect and is an adequate model for studying the impact of systemic inflammation in Parkinson's disease.
C1 [Ugalde-Muniz, Perla; Chavarria, Anahi] Univ Nacl Autonoma Mexico, Fac Med, Unidad Invest Med Expt, Mexico City 06726, DF, Mexico.
   [Fetter-Pruneda, Ingrid A.] Univ Nacl Autonoma Mexico, Ctr Ciencias Complejidad, Mexico City 04510, DF, Mexico.
   [Navarro, Luz] Univ Nacl Autonoma Mexico, Fac Med, Dept Fisiol, Mexico City 04510, DF, Mexico.
   [Garcia, Esperanza] Inst Nacl Neurol & Neurocirugia Manuel Velasco Su, Lab Neuroinmunol, Mexico City 14269, DF, Mexico.
C3 Universidad Nacional Autonoma de Mexico; Universidad Nacional Autonoma
   de Mexico; Universidad Nacional Autonoma de Mexico
RP Chavarría, A (corresponding author), Univ Nacl Autonoma Mexico, Fac Med, Unidad Invest Med Expt, Mexico City 06726, DF, Mexico.
EM anahi.chavarria@gmail.com
RI Fetter, Ingrid/KLZ-9907-2024; Navarro, Luz/JEP-6302-2023; Chavarria,
   Anahi/AAD-6636-2019; Muñiz, Perla Eugenia/AGZ-1396-2022
OI Chavarria, Anahi/0000-0002-6412-0461; Fetter-Pruneda,
   Ingrid/0000-0002-9122-3159; Navarro, Luz/0000-0002-5519-0871
FU CONACYT [CVU508658]; Facultad de Medicina, Universidad Nacional Autonoma
   de Mexico [IN222215, IN223417]; Direccion General de Asuntos del
   Personal Academico, Universidad Nacional Autonoma de Mexico [IN222215,
   IN223417]
FX Perla Ugalde-Muniz is a doctoral student from Programa de Doctorado en
   Ciencias Biologicas, Universidad Nacional Autonoma de Mexico (UNAM), and
   received fellowship CVU508658 from CONACYT. The authors are grateful to
   Alejandra Butanda for her assistance with ELISA experiments. The authors
   wish to acknowledge Rafael Munoz Garcia, Ricardo Vargas Orozco, and
   Daniel Sanchez Almaraz for their technical assistance with animal
   handling and housing. The authors are grateful to Bernardo Pohlenz for
   his artwork assistance. Facultad de Medicina and Direccion General de
   Asuntos del Personal Academico, Universidad Nacional Autonoma de Mexico
   (IN222215 and IN223417), provided funding for this research.
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NR 101
TC 25
Z9 27
U1 2
U2 13
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PD JAN 13
PY 2020
VL 2020
AR 4807179
DI 10.1155/2020/4807179
PG 19
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA KG6DT
UT WOS:000510041700001
PM 32015787
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Chen, XF
   Gao, Y
   Yang, XB
   Zhang, HY
   Mo, ZN
   Tan, AH
AF Chen, Xuefen
   Gao, Yong
   Yang, Xiaobo
   Zhang, Haiying
   Mo, Zengnan
   Tan, Aihua
TI Relationship of FTO gene variations with NAFLD risk in Chinese
   men
SO OPEN LIFE SCIENCES
LA English
DT Article
DE FTO gene; nonalcoholic fatty liver disease; SNPs; obesity
ID NONALCOHOLIC FATTY LIVER; OXIDATIVE STRESS; BODY-FAT; ASSOCIATION;
   OBESITY; DISEASE; VARIANTS; MASS; STEATOHEPATITIS; POLYMORPHISM
AB Background - Fat mass and obesity-associated (FTO) gene is an obesity susceptibility gene and its relationship with the nonalcoholic fatty liver disease (NAFLD) remains unclear. This study aims to investigate the relationships of FTO gene variations with NAFLD risk in a Chinese male population.
   Methods - A 1:2 matched case-control study was performed on 275 cases of NAFLD and 550 controls matched for age. Nine of the FTO gene single nucleotide polymorphisms (SNPs) were genotyped.
   Results - Logistic regression analysis found that FTO rs1477196 was significantly associated with the susceptibility to NAFLD in recessive genetic models [unadjusted odds ratio (OR) = 2.52, 95% confidence interval (CI): 1.22-5.19, P = 0.012] and the relativity weakened after further adjustment for body mass index (BMI), uric acid, metabolic syndrome, smoking, and drinking (adjusted OR = 2.18, 95% CI: 0.96-4.99, P = 0.06). In the obese group, the AA + AG genotypes of rs1121980 and rs9940128 were associated with a decreased risk of NAFLD, when compared with the GG genotype, respectively (rs1121980: adjusted OR = 0.62, 95% CI = 0.39-0.99, P = 0.044; rs9940128: adjusted OR = 0.61, 95% CI = 0.38-0.97, P = 0.038). Furthermore, rs1477196 was associated with the severity of NAFLD (OR = 2.95, 95% CI = 1.09-7.94, P = 0.034).
   Conclusions - Our results demonstrated that the FTO gene was related to the presence and severity of NAFLD in a Chinese male population, and the relationships of the tested SNPs with NAFLD are most probably mediated by BMI.
C1 [Chen, Xuefen; Tan, Aihua] Guangxi Med Univ, Dept Chemotherapy, Affiliated Tumor Hosp, Nanning 530021, Guangxi, Peoples R China.
   [Gao, Yong; Yang, Xiaobo; Zhang, Haiying; Mo, Zengnan] Guangxi Med Univ, Ctr Genom & Personalized Med, Nanning 530021, Guangxi, Peoples R China.
C3 Guangxi Medical University; Guangxi Medical University
RP Tan, AH (corresponding author), Guangxi Med Univ, Dept Chemotherapy, Affiliated Tumor Hosp, Nanning 530021, Guangxi, Peoples R China.
EM tahanna@126.com
RI Yang, Xiaobo/AAD-6333-2019
OI mo, zengnan/0000-0002-3047-3138
FU Foundation for Young and Middle-Aged Teachers' Basic Ability Enhancement
   Project of Guangxi [KY2016YB074]; Guangxi Natural Science Foundation
   [2016GXNSFAA380152]
FX This study was supported by the Foundation for Young and Middle-Aged
   Teachers' Basic Ability Enhancement Project of Guangxi (grant no.
   KY2016YB074) and the Guangxi Natural Science Foundation (grant no.
   2016GXNSFAA380152).
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NR 30
TC 4
Z9 4
U1 0
U2 6
PU DE GRUYTER POLAND SP Z O O
PI WARSAW
PA BOGUMILA ZUGA 32A STR, 01-811 WARSAW, MAZOVIA, POLAND
SN 2391-5412
J9 OPEN LIFE SCI
JI Open Life Sci.
PY 2020
VL 15
IS 1
BP 860
EP 867
DI 10.1515/biol-2020-0081
PG 8
WC Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics
GA PE1FB
UT WOS:000598116000001
PM 33817272
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Ronis, MJ
   Blackburn, ML
   Shankar, K
   Ferguson, M
   Cleves, MA
   Badger, TM
AF Ronis, Martin J.
   Blackburn, Michael L.
   Shankar, Kartik
   Ferguson, Matthew
   Cleves, Mario A.
   Badger, Thomas M.
TI Highlight article: Estradiol and NADPH oxidase crosstalk regulates
   responses to high fat feeding in female mice
SO EXPERIMENTAL BIOLOGY AND MEDICINE
LA English
DT Article
DE Estradiol; NADPH-oxidase; adiposity obesity
ID INSULIN-RESISTANCE; GENE-EXPRESSION; ADIPOSE; INFLAMMATION; DEFICIENCY;
   ESTROGEN; OBESE; ADIPOCYTES; METABOLISM; STRESS
AB We previously demonstrated protection against high fat-induced obesity in female but not male p47(phox-/-) mice lacking NADPH oxidase NOX1/2 activity. To test the role of estradiol (E2)-NOX crosstalk in development of this sexually dimorphic phenotype, we fed diets containing 42% fat/0.5% cholesterol to intact and ovariectomized wild type female C57BL/6 mice and female p47(phox-/-) mice and to ovariectomized mice where the diet was supplemented with an 1 mg/kg 17 beta estradiol (E2) for 12 weeks from PND28. Weight gain, gonadal fat pad weight, serum leptin and adiponectin, and adipose tissue inflammation were greater in intact wild type vs. p47 mice (P < 0.05). Genotype effects on body weight/fat mass were abolished after ovariectomized and restored in OVX + E2 mice (P < 0.05). The mRNA of downstream PPAR gamma targets CD36, lipoprotein lipase, and leptin was higher in intact wild type vs. p47(phox-/-) mice mice (P < 0.05). Likewise, intact high fat-fed wild type mice had higher expression of the cytokine Mcp1; the pyroptosis marker Nirp3 and matrix remodeling and fibrosis markers Mmp2, Col1A1, and Col6a3 mRNAs (P < 0.05). These genotype effects were reversed and restored by ovariectomized and OVX + E2, respectively (P < 0.05). These data suggest that triglyceride accumulation in adipose tissue and development of adipose tissue injury in response to feeding diets high in fat and cholesterol is regulated by the balance between NOX-dependent reactive oxygen species signaling and E2-signaling during development. Loss of estrogens post menopause may increase the risk of obesity and metabolic syndrome as the result disinhibition of reactive oxygen species signaling.
C1 [Ronis, Martin J.; Blackburn, Michael L.; Shankar, Kartik; Ferguson, Matthew; Cleves, Mario A.; Badger, Thomas M.] Univ Arkansas Med Sci, Dept Pediat, Little Rock, AR 72205 USA.
   [Ronis, Martin J.; Blackburn, Michael L.; Shankar, Kartik; Ferguson, Matthew; Cleves, Mario A.; Badger, Thomas M.] Arkansas Childrens Nutr Ctr, Little Rock, AR 72202 USA.
   [Ronis, Martin J.] Louisiana State Univ, Dept Pharmacol & Expt Therapeut, Hlth Sci Ctr, New Orleans, LA 70112 USA.
C3 University of Arkansas System; University of Arkansas Medical Sciences;
   Louisiana State University System; Louisiana State University Health
   Sciences Center New Orleans
RP Ronis, MJ (corresponding author), Univ Arkansas Med Sci, Dept Pediat, Little Rock, AR 72205 USA.; Ronis, MJ (corresponding author), Arkansas Childrens Nutr Ctr, Little Rock, AR 72202 USA.; Ronis, MJ (corresponding author), Louisiana State Univ, Dept Pharmacol & Expt Therapeut, Hlth Sci Ctr, New Orleans, LA 70112 USA.
EM mronis@lsuhsc.edu
OI Shankar, Kartik/0000-0002-7964-9026
FU United States Department of Agriculture, Agricultural Service Project
   [6026-51000-010-05S];  [R37 AA018282]
FX This article was funded in part by United States Department of
   Agriculture, Agricultural Service Project 6026-51000-010-05S and by R37
   AA018282.
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NR 30
TC 7
Z9 7
U1 0
U2 4
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1535-3702
EI 1535-3699
J9 EXP BIOL MED
JI Exp. Biol. Med.
PD JUL
PY 2019
VL 244
IS 10
BP 834
EP 845
DI 10.1177/1535370219853563
PG 12
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA IK3QI
UT WOS:000476503100006
PM 31161785
OA Green Published
DA 2025-06-11
ER

PT J
AU Tournadre, A
   Vial, G
   Capel, F
   Soubrier, M
   Boirie, Y
AF Tournadre, Anne
   Vial, Gaelle
   Capel, Frederic
   Soubrier, Martin
   Boirie, Yves
TI Sarcopenia
SO JOINT BONE SPINE
LA English
DT Review
DE Sarcopenia; Muscle; Fat mass
ID MUSCLE PROTEIN-SYNTHESIS; LOW LEAN MASS; RHEUMATOID-ARTHRITIS;
   BODY-COMPOSITION; SKELETAL-MUSCLE; RECEPTOR ANTIBODY; PHYSICAL FUNCTION;
   DOUBLE-BLIND; ELDERLY-MEN; GAIT SPEED
AB Sarcopenia is defined as a combination of low muscle mass with low muscle function. The term was first used to designate the loss of muscle mass and performance associated with aging. Now, recognized causes of sarcopenia also include chronic disease, a physically inactive lifestyle, loss of mobility, and malnutrition. Sarcopenia should be differentiated from cachexia, which is characterized not only by low muscle mass but also by weight loss and anorexia. Sarcopenia results from complex and interdependent pathophysiological mechanisms that include aging, physical inactivity, neuromuscular compromise, resistance to postprandial anabolism, insulin resistance, lipotoxicity, endocrine factors, oxidative stress, mitochondrial dysfunction, and inflammation. The prevalence of sarcopenia ranges from 3% to 24% depending on the diagnostic criteria used and increases with age. Among patients with rheumatoid arthritis 20% to 30% have sarcopenia, which correlates with disease severity. Sarcopenia exacts a heavy toll of functional impairment, metabolic disorders, morbidity, mortality, and healthcare costs. Thus, the consequences of sarcopenia include disability, quality of life impairments, falls, osteoporosis, dyslipidemia, an increased cardiovascular risk, metabolic syndrome, and immunosuppression. The adverse effects of sarcopenia are particularly great in patients with a high fat mass, a condition known as sarcopenic obesity. The diagnosis of sarcopenia rests on muscle mass measurements and on functional tests that evaluate either muscle strength or physical performance (walking, balance). No specific biomarkers have been identified to date. The management of sarcopenia requires a multimodal approach combining a sufficient intake of high-quality protein and fatty acids, physical exercise, and antiinflammatory medications. Selective androgen receptor modulators and anti-myostatin antibodies are being evaluated as potential stimulators of muscle anabolism. (C) 2018 Societe francaise de rhumatologie. Published by Elsevier Masson SAS. All rights reserved.
C1 [Tournadre, Anne; Vial, Gaelle; Soubrier, Martin] CHU Clermont Ferrand, Serv Rhumatol, 58 Rue Montalembert, F-63003 Clermont Ferrand, France.
   [Boirie, Yves] CHU Clermont Ferrand, Hop G Montpied, Serv Nutr Clin, F-63003 Clermont Ferrand, France.
   [Tournadre, Anne; Vial, Gaelle; Capel, Frederic; Soubrier, Martin; Boirie, Yves] Univ Clermont Auvergne, INRA, UMR1019, Unite Nutr Humaine, F-63000 Clermont Ferrand, France.
C3 Universite Clermont Auvergne (UCA); CHU Clermont Ferrand; Universite
   Clermont Auvergne (UCA); CHU Clermont Ferrand; Universite Clermont
   Auvergne (UCA); INRAE
RP Tournadre, A (corresponding author), CHU Clermont Ferrand, Hop G Montpied, Serv Rhumatol, 58 Rue Montalembert, F-63003 Clermont Ferrand, France.
EM atournadre@chu-clermontferrand.fr
RI Tournadre, Anne/LCE-4407-2024; Boirie, Yves/KQC-2016-2024; Capel,
   Frederic/AAW-8838-2020
OI Boirie, Yves/0000-0002-3999-1599; Capel, Frederic/0000-0002-0133-0277
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NR 65
TC 237
Z9 259
U1 43
U2 484
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 1297-319X
EI 1778-7254
J9 JOINT BONE SPINE
JI Joint Bone Spine
PD MAY
PY 2019
VL 86
IS 3
BP 309
EP 314
DI 10.1016/j.jbspin.2018.08.001
PG 6
WC Rheumatology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Rheumatology
GA HW0MW
UT WOS:000466376100005
PM 30098424
OA Bronze, Green Submitted
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Cao, B
   Jin, M
   Brietzke, E
   McIntyre, RS
   Wang, DF
   Rosenblat, JD
   Ragguett, RM
   Zhang, CB
   Sun, XY
   Rong, C
   Wang, JY
AF Cao, Bing
   Jin, Min
   Brietzke, Elisa
   McIntyre, Roger S.
   Wang, Dongfang
   Rosenblat, Joshua D.
   Ragguett, Renee-Marie
   Zhang, Chuanbo
   Sun, Xiaoyu
   Rong, Carola
   Wang, Jingyu
TI Serum metabolic profiling using small molecular water-soluble
   metabolites in individuals with schizophrenia: A longitudinal study
   using a pre-post-treatment design
SO PSYCHIATRY AND CLINICAL NEUROSCIENCES
LA English
DT Article
DE liquid chromatography-mass spectrometry; metabolic profiling;
   metabolomics; schizophrenia
ID OXIDATIVE STRESS; L-CARNITINE; AMINO-ACID; LC-MS; PLASMA; TRANSPORT;
   GLUTAMATE; DYSFUNCTION; VALIDATION; HYPOTHESIS
AB Aim We sought to compare alterations in serum bioenergetic markers within a well-characterized sample of adults with schizophrenia at baseline and after 8 weeks of pharmacological treatment with the hypothesis that treatment would be associated with significant changes in bioenergetic markers given the role of bioenergetic dysfunction in schizophrenia. Methods We recruited adults with schizophrenia (n = 122) who had not received pharmacological treatment for at least 1 month prior to enrollment, including drug-naive (i.e., first-episode) participants and treatment non-adherent participants. Pre- and post-treatment serum samples were analyzed using liquid chromatography-tandem mass spectrometry. Results Metabolites with the greatest change, when comparing pre- and post-treatment levels, were identified revealing 14 water-soluble metabolites of interest. The composition of these metabolites was: amino acids (n = 6), carnitines (n = 4), polar lipids (n = 3), and organic acid (n = 1). All amino acids and lysophosphatidylcholines (LysoPC) were increased, while the four carnitines - oleoylcarnitine, L-palmitoylcarnitine, linoleyl carnitine, and L-acetylcarnitine - were decreased post-treatment. Of these metabolite biomarkers, six - oleoylcarnitine, linoleyl carnitine, L-acetylcarnitine, LysoPC(15:0), D-glutamic acid, and L-arginine - were identified as having most consistently and predictably changed after 8 weeks of treatment. Conclusion The current study identified several bioenergetic markers that consistently change with pharmacological treatment. These bioenergetic changes may provide further insights into the pathophysiology of schizophrenia along with furthering our understanding of the mechanisms subserving both the effects (e.g., antipsychotic effects) and side-effects (e.g., metabolic syndrome) of antipsychotics.
C1 [Cao, Bing; Wang, Dongfang; Sun, Xiaoyu; Wang, Jingyu] Peking Univ, Sch Publ Hlth, Dept Lab Sci & Technol, Beijing, Peoples R China.
   [Jin, Min] Baotou Med Coll, Sch Publ Hlth, Baotou, Peoples R China.
   [Brietzke, Elisa; McIntyre, Roger S.; Rosenblat, Joshua D.; Ragguett, Renee-Marie; Rong, Carola] Univ Hlth Network, Toronto Western Hosp, Mood Disorders Psychopharmacol Unit, Toronto, ON, Canada.
   [McIntyre, Roger S.] Brain & Cognit Discovery Fdn, Toronto, ON, Canada.
   [Zhang, Chuanbo] Weifang Mental Hlth Ctr, Weifang, Peoples R China.
   [Wang, Jingyu] Beijing Key Lab Toxicol Res & Risk Assessment Foo, Beijing, Peoples R China.
C3 Peking University; Baotou Medical College; University of Toronto;
   University Health Network Toronto
RP Wang, JY (corresponding author), Peking Univ, Sch Publ Hlth, Dept Lab Sci & Technol, Beijing, Peoples R China.
EM wjy@bjmu.edu.cn
RI Brietzke, Elisa/G-9559-2012; Jin, Min/KFT-2653-2024; Rong,
   Carola/GOP-1312-2022; McIntyre, Roger/AAU-1000-2020
OI Rosenblat, Joshua/0000-0002-4773-2191
FU Medicine Interdisciplinary Seed Fund [BMU20140435]; Health Science
   Center, Peking University
FX This work was supported by the Medicine Interdisciplinary Seed Fund
   (BMU20140435) by Health Science Center, Peking University. The funding
   agents had no role in: the design or conduct of the study; the
   collection, management, analysis, or interpretation of the data; or the
   preparation, review, or approval of the manuscript. The authors thank
   Beijing Omics Bio-tech Co., Ltd. for their kind help in data collection
   for this study. The authors alone are responsible for the content and
   writing of the paper. We thank team members for their support and
   contributions to this study.
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NR 61
TC 26
Z9 27
U1 0
U2 21
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1323-1316
EI 1440-1819
J9 PSYCHIAT CLIN NEUROS
JI Psychiatry Clin. Neurosci.
PD MAR
PY 2019
VL 73
IS 3
SI SI
BP 100
EP 108
DI 10.1111/pcn.12779
PG 9
WC Clinical Neurology; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA HN6QQ
UT WOS:000460311200002
PM 30156046
OA Bronze
DA 2025-06-11
ER

PT J
AU Cooper, MA
   McCoin, C
   Pei, D
   Thyfault, JP
   Koestler, D
   Wright, DE
AF Cooper, Michael A.
   McCoin, Colin
   Pei, Dong
   Thyfault, John P.
   Koestler, Devin
   Wright, Douglas E.
TI Reduced mitochondrial reactive oxygen species production in peripheral
   nerves of mice fed a ketogenic diet
SO EXPERIMENTAL PHYSIOLOGY
LA English
DT Article
DE dorsal root ganglion; fat; ketogenic; metabolism; mitochondria; sciatic
   nerve
ID RESPIRATORY-CHAIN DYSFUNCTION; DORSAL-ROOT GANGLIA; DIABETIC-NEUROPATHY;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; LIPID-METABOLISM; SENSORY NEURONS;
   DISEASE; INFLAMMATION; ALLODYNIA
AB Metabolic syndrome and obesity are increasing epidemics that significantly impact the peripheral nervous system and lead to negative changes in sensation and peripheral nerve function. Research to understand the consequences of diet, obesity and fuel usage in sensory neurons has commonly focused on glucose metabolism. Here, we tested whether mouse sensory neurons and nerves have the capacity to metabolize fat-based fuels (palmitoyl-CoA) and whether these effects are altered by feeding of a ketogenic (90%kcal fat) diet compared with a control diet (14%kcal fat). Male C57Bl/6 mice were placed on the diets for 10weeks, and after the mice were killed, the dorsal root ganglion (DRG) and sciatic nerve (SN) were placed in an Oroboros oxygraph-2K to examine diet-induced alterations in metabolism (respiration) of palmitoyl-CoA and H2O2 emission (fluorescence). In addition, RNAseq was performed on the DRG of mice fed a control or a ketogenic diet for 12weeks, and genes associated with mitochondrial respiratory function were analysed. Our results suggest that the sciatic nerves from mice fed a ketogenic diet display reduced O-2 respiration and H2O2 emission when metabolizing palmitoyl-CoA compared with mice fed a control diet. Assessments of changes in mRNA gene expression reveal alterations in genes encoding the NADH dehydrogenase complex and complexIV, which could alter production of reactive oxygen species. These new findings highlight the ability of sensory neurons and axons to oxidize fat-based fuel sources and show that these mechanisms are adaptable to dietary changes.
C1 [Cooper, Michael A.; Wright, Douglas E.] Univ Kansas, Dept Anat & Cell Biol, Med Ctr, Kansas City, KS 66160 USA.
   [McCoin, Colin; Thyfault, John P.] Univ Kansas, Dept Mol & Integrat Physiol, Med Ctr, Kansas City, KS 66160 USA.
   [Pei, Dong; Koestler, Devin] Univ Kansas, Dept Biostat, Med Ctr, Kansas City, KS 66160 USA.
C3 University of Kansas; University of Kansas Medical Center; University of
   Kansas; University of Kansas Medical Center; University of Kansas;
   University of Kansas Medical Center
RP Wright, DE (corresponding author), Univ Kansas, Dept Anat & Cell Biol, Med Ctr, Kansas City, KS 66160 USA.
EM dwright@kumc.edu
RI Thyfault, John/JMB-3070-2023; Koestler, Devin/D-7902-2015
OI Thyfault, John/0000-0001-7920-7466; McCoin, Colin/0000-0002-8557-6441;
   Pei, Dong/0000-0002-8367-729X; Koestler, Devin/0000-0002-0598-0146
FU National Institutes of Health (NIH) [RO1NS43314]; Idea Network of
   Biomedical Research Excellence (INBRE) Program [P20GM103418]; Kansas
   Intellectual and Developmental Disabilities Research Center
   [U54HD090216]; Veterans Affairs Merit Review [1I01Bx002567-01]
FX This work was supported by National Institutes of Health (NIH) grants
   RO1NS43314 (D.E.W.), P20GM103418 from the Idea Network of Biomedical
   Research Excellence (INBRE) Program (D.E.W., C.M. and J.P.T.), the
   Kansas Intellectual and Developmental Disabilities Research Center,
   U54HD090216 (D.E.W.) and Veterans Affairs Merit Review 1I01Bx002567-01
   (J.P.T.).
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NR 26
TC 18
Z9 22
U1 0
U2 16
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0958-0670
EI 1469-445X
J9 EXP PHYSIOL
JI Exp. Physiol.
PD SEP 1
PY 2018
VL 103
IS 9
BP 1206
EP 1212
DI 10.1113/EP087083
PG 7
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA GS0VS
UT WOS:000443227700006
PM 30088302
OA Bronze, Green Accepted
DA 2025-06-11
ER

PT J
AU Chaudhry, SR
   Akram, A
   Aslam, N
   Asif, M
   Wajid, M
   Kinfe, T
   Jabeen, Q
   Muhammad, S
AF Chaudhry, Shafqat Rasul
   Akram, Adnan
   Aslam, Naveed
   Asif, Muhammad
   Wajid, Muhammad
   Kinfe, Thomas
   Jabeen, Qaiser
   Muhammad, Sajjad
TI ANTIDIABETIC AND ANTIDYSLIPIDEMIC EFFECTS OF HELIOTROPIUM
   STRIGOSUM IN RAT MODELS OF TYPE I AND TYPE II DIABETES
SO ACTA POLONIAE PHARMACEUTICA
LA English
DT Article
DE antihyperglycemia; hypoglycemia; alloxan; antihyperlipidcmia;
   hypolipidcmia; fructose-fed diabetes model; insulin resistance;
   metabolic syndrome
ID CORONARY-HEART-DISEASE; INSULIN-RESISTANCE; OXIDATIVE STRESS;
   ANTIOXIDANT ACTIVITIES; TRIGLYCERIDE LEVELS; MEDICINAL-PLANTS; AQUEOUS
   EXTRACT; ALLOXAN; SERUM; PLASMA
AB Heliorropium snigostim WilId. (Boniginacear) is used traditionally as a laxative, diuretic, and as a treatment for snake bites and stings of nettles. Recent investigations have shown anti-inflammatory and antioxidant activity of H. srrigosum. However, antihyperglycemic and antidyslipidemic activity of H. strigosum has not been investigated to date and we aimed to explore these activities of the crude aqueous methanolic extract of the aerial parts of H. snigosion (Hs.Cr). Hs.Cr was administered orally at doses of 100, 300. and 500 mg/kg in alloxan-induced diabetic rats (type I diabetes) and fructose-fed rats (type II diabetes). The fasting blood glucose (FBG) concentration was assessed by glucometer, while serum total cholesterol, triglycerides and HDL were estimated by using standard kits. The FBG concentration significantly (p < 0.05) decreased in dose-dependent pattern in both alloxan-induced diabetic and fructose-fed rats on Hs.Cr administration. The percentage glucose reductions in alloxanized rats with glibenclamide, Hs.Cr 100, 300. and 500 mg/kg were obeserved to be 67, 36.56 and 62%, respectively. In fructose-fed rats, the percentage glucose redutions associated with metformin, Hs.Cr 100, 300, and 500 mg/kg were 23, 5. 11 and 12%, respectively. The extract also corrected the dyslipidemia associated with fructose and alloxan-induced diabetes by significantly (p < 0.001) decreasing the concentration of serum total cholesterol, triglycerides and LDL and by increasing HDL concentration. Our data demonstrate that the H, srrigosunr has antidiabetic and antidyslipidemic effects, thus encouraging further studies.
C1 [Chaudhry, Shafqat Rasul; Akram, Adnan; Aslam, Naveed; Asif, Muhammad; Wajid, Muhammad; Jabeen, Qaiser] Islamia Univ Bahawalpur, Fac Pharm, Bahawalpur 63100, Pakistan.
   [Chaudhry, Shafqat Rasul; Kinfe, Thomas; Muhammad, Sajjad] Univ Bonn, Univ Hosp Bonn, Dept Neurosurg, D-53105 Bonn, Germany.
C3 Islamia University of Bahawalpur; University of Bonn
RP Chaudhry, SR (corresponding author), Sigmund Freud Str 25, D-53105 Bonn, Germany.
EM shafqatrasul@yahoo.com
RI Jabeen, Qaiser/IZE-0630-2023; Aslam, Naveed/AAD-5637-2020; Kinfe,
   Thomas/AAY-7093-2020; Warsi, Muhammad/AAE-3020-2022; Chaudhry, Shafqat
   Rasul/AFM-0299-2022; Sajjad, Muhammad/AEB-9967-2022; Asif,
   Muhammad/IQS-5311-2023
OI Kinfe, Thomas M./0000-0002-4888-543X; Muhammad,
   Sajjad/0000-0002-6734-7979; Aslam, Naveed/0000-0002-6305-3447; Jabeen,
   Qaiser/0000-0002-6346-860X
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NR 73
TC 6
Z9 7
U1 0
U2 6
PU POLSKIE TOWARZYSTWO FARMACEUTYCZNE
PI WARSAW
PA DLUGA 16, 00-238 WARSAW, POLAND
SN 0001-6837
EI 2353-5288
J9 ACTA POL PHARM
JI ACTA POL. PHARM.
PD NOV-DEC
PY 2016
VL 73
IS 6
BP 1575
EP 1586
PG 12
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA EM3RC
UT WOS:000395231300020
PM 29634112
DA 2025-06-11
ER

PT J
AU Kim, J
   Kim, MG
   Kang, S
   Kim, BR
   Baek, MY
   Park, YM
   Shin, MS
AF Kim, JinShil
   Kim, Myeong Gun
   Kang, Sewon
   Kim, Bong Roung
   Baek, Min Young
   Park, Yae Min
   Shin, Mi-Seung
TI Obesity and Hypertension in Association with Diastolic Dysfunction Could
   Reduce Exercise Capacity
SO KOREAN CIRCULATION JOURNAL
LA English
DT Article
DE Obesity; Hypertension; Echocardiography; Diastolic function; Exercise
   capacity
ID METABOLIC SYNDROME; PREVALENCE; PROGRAM; RISK
AB Background and Objectives: Empirical evidence is lacking on the cumulative disease burden of obesity and hypertension and its impact on cardiac function and exercise capacity. The purpose of this study was to determine whether the presence of obesity and hypertension together was associated with cardiac dysfunction and exercise capacity.
   Subjects and Methods: Using a retrospective study design, medical records were reviewed for echocardiographic and treadmill exercise stress test data. Subjects were grouped according to four categories: normal control, obese, hypertensive, or obese and hypertensive.
   Results: Obese, hypertensive persons showed significantly lower Ea and E/A ratio and greater E/Ea ratio, deceleration time, left ventricular (LV) mass, and LV mass index compared to their counter parts (normal control, obese and/or hypertensive) (all p<0.05), after controlling for age and sex. After controlling for age and sex, significant differences in exercise capacity indices were found, with the obese group having shorter exercise time, lower metabolic equivalents, and lower maximal oxygen uptake than the normal control, hypertensive, or both groups (all p<0.05). The hypertensive or obese and hypertensive group had greater maximal blood pressure compared with the normal control group (all p<0.001). Obese and hypertensive persons were approximately three times more likely to have diastolic dysfunction (odd ratio=2.96, p=0.001), when compared to the reference group (normotensive, non-obese, or hypertensive only persons).
   Conclusion: Diastolic dysfunction was associated with obesity and/or hypertension. The cumulative risk of obesity and hypertension and their impact on diastolic dysfunction which could be modifiable could reduce exercise capacity.
C1 [Kim, JinShil] Gachon Univ, Coll Nursing, Inchon, South Korea.
   [Kim, Myeong Gun; Baek, Min Young; Park, Yae Min; Shin, Mi-Seung] Gachon Univ, Gil Med Ctr, Dept Internal Med, Inchon, South Korea.
   [Kang, Sewon] Dongseoi Univ, Coll Nursing, Pusan, South Korea.
   [Kim, Bong Roung] Seoul Med Ctr, Dept Internal Med, Seoul, South Korea.
   [Park, Yae Min; Shin, Mi-Seung] Gachon Univ, Coll Med, Inchon, South Korea.
C3 Gachon University; Gachon University; Seoul Medical Center; Gachon
   University
RP Shin, MS (corresponding author), Gachon Univ, Gil Med Ctr, Dept Internal Med, Div Cardiol, 21 Namdong Daero 774Beon Gil, Inchon 21565, South Korea.
EM msshin@gilhospital.com
FU Korean Society of Cardiology [2011-10]
FX This study was supported by a grant from the Korean Society of
   Cardiology (#2011-10).
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NR 29
TC 13
Z9 14
U1 0
U2 10
PU KOREAN SOC CARDIOLOGY
PI SEOUL
PA 101-1704, LOTTE CASTLE PRESIDENT, 109, MAPO-DAERO, MAPO-GU, SEOUL,
   04146, SOUTH KOREA
SN 1738-5520
EI 1738-5555
J9 KOREAN CIRC J
JI Korean Circ. J.
PD MAY
PY 2016
VL 46
IS 3
BP 394
EP 401
DI 10.4070/kcj.2016.46.3.394
PG 8
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA DN3GJ
UT WOS:000376950100012
PM 27275176
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Bañuls, C
   Rovira-Llopis, S
   López-Doménech, S
   Veses, S
   Victor, VM
   Rocha, M
   Hernández-Mijares, A
AF Banuls, Celia
   Rovira-Llopis, Susana
   Lopez-Domenech, Sandra
   Veses, Silvia
   Victor, Victor M.
   Rocha, Milagros
   Hernandez-Mijares, Antonio
TI Effect of consumption of a carob pod inositolen-riched beverage on
   insulin sensitivity and inflammation in middle-aged prediabetic subjects
SO FOOD & FUNCTION
LA English
DT Article
ID NECROSIS-FACTOR-ALPHA; METABOLIC SYNDROME; ENDOTHELIAL DYSFUNCTION;
   CARDIOVASCULAR RISK; ARABINOXYLAN FIBER; GLUCOSE-METABOLISM;
   DIABETES-MELLITUS; OXIDATIVE STRESS; RESISTANCE; PINITOL
AB This study assessed the effects of an inositol-enriched beverage (IEB) on blood glucose levels and inflammation status in subjects with an impaired fasting glucose (IFG) state according to body mass index (BMI). This was a 12 week, double-blind, randomized, controlled trial employing forty-four IFG subjects (fasting glucose levels 100-125 mg dl(-1)) that were divided into two intervention groups: one receiving a IEB (n = 24) containing mainly pinitol (2.0 g twice a day), and the other a sweetened beverage based on sucrose (SB; n = 20). Anthropometric and biochemical measurements, postprandial and fasting nocturnal glycaemia (continuous glucose monitoring system), and inflammatory parameters (IL-6 and TNF-alpha) were analyzed at baseline and after intervention according to BMI (non-obese: BMI <30 kg m(-2) or obese: BMI >= 30 kg m(-2)). Non-obese subjects who consumed IEB exhibited a significant decrease in insulin (-14.4%), HOMA-IR index (-15.1%) and percentage of glucose change after postprandial and fasting nocturnal periods (-10.0% and -10.3%, respectively) compared with the SB group (-2.35% and 10.2%, respectively) although they did not show any change in inflammatory cytokine levels. By contrast, obese subjects who consumed IEB showed a smaller variation in glucose levels after nocturnal fasting (-4.34%) and a marked decrease in IL-6 and TNF-alpha (p < 0.05). These findings support that consumption of IEB in prediabetic subjects produces a response that is dependent on BMI, with a clear improvement of insulin resistance and postprandial and nocturnal glycemia in non-obese subjects and a marked anti-inflammatory response in obese subjects.
C1 [Banuls, Celia; Rovira-Llopis, Susana; Victor, Victor M.; Rocha, Milagros; Hernandez-Mijares, Antonio] Univ Hosp Dr Peset, Fdn Promot Hlth & Biomed Res Valencian Reg FISABI, Serv Endocrinol, Avda Gaspar Aguilar 90, Valencia 46017, Spain.
   [Banuls, Celia; Rovira-Llopis, Susana; Victor, Victor M.; Rocha, Milagros; Hernandez-Mijares, Antonio] Inst Hlth Res INCLIVA, Av Blasco Ibanez 17, Valencia 46010, Spain.
   [Victor, Victor M.; Rocha, Milagros] Univ Valencia, CIBER Hepat & Digest Dis, CIBER Res Grp CB06 04 0071, Av Blasco Ibanez 13, Valencia 46010, Spain.
   [Victor, Victor M.] Univ Valencia, Fac Med, Dept Physiol, Av Blasco Ibanez 13, Valencia 46010, Spain.
   [Hernandez-Mijares, Antonio] Univ Valencia, Fac Med, Dept Med, Av Blasco Ibanez 13, Valencia 46010, Spain.
C3 CIBER - Centro de Investigacion Biomedica en Red; CIBEREHD; University
   of Valencia; University of Valencia; University of Valencia
RP Bañuls, C; Rocha, M; Hernández-Mijares, A (corresponding author), Univ Hosp Dr Peset, Fdn Promot Hlth & Biomed Res Valencian Reg FISABI, Serv Endocrinol, Avda Gaspar Aguilar 90, Valencia 46017, Spain.; Bañuls, C; Rocha, M; Hernández-Mijares, A (corresponding author), Inst Hlth Res INCLIVA, Av Blasco Ibanez 17, Valencia 46010, Spain.; Rocha, M (corresponding author), Univ Valencia, CIBER Hepat & Digest Dis, CIBER Res Grp CB06 04 0071, Av Blasco Ibanez 13, Valencia 46010, Spain.; Hernández-Mijares, A (corresponding author), Univ Valencia, Fac Med, Dept Med, Av Blasco Ibanez 13, Valencia 46010, Spain.
EM celia.banuls@uv.es; milagros.rocha@uv.es; hernandez_antmij@gva.es
RI Domènech, Sandra/AAA-9732-2020; victor, victor/Q-4843-2019; Rocha,
   Milagros/I-4987-2015; Rovira-Llopis, Susana/AAX-8666-2021; Banuls,
   Celia/H-7359-2017
OI Rocha, Milagros/0000-0003-2923-6546; VICTOR, VICTOR/0000-0002-3027-3945;
   Lopez Domenech, Sandra/0000-0003-2067-9308; Rovira-Llopis,
   Susana/0000-0002-8476-5128; Banuls, Celia/0000-0001-8077-7642
FU University of Valencia; Fund for Health Research (FIS) [PI15/01424,
   PI13/1025, PI13/0073]; European Regional Development Fund of the
   European Union (FEDER, "A way to build Europe"); FISABIO [UGP-15-220,
   UGP-15-193]; Conselleria de Educacion, Investigacion, Cultura y Deporte
   de la Generalitat Valenciana [PROMETEOII2014/035, GV/2016/169];
   Valencian Regional Ministry of Health; Carlos III Health Institute
   [CES10/030]; FIS [C10/00360, CD14/00043]
FX We thank B. Normanly for his editorial assistance, I. Soria-Cuenca for
   her work in the extraction of the biological samples, Rosa Falcon and
   Carmen Ramirez (FISABIO) for their technical assistance and R. Salom and
   R. Garcia-Bou of WILD-Valencia SAU (Spain) for supplying the Fruit Up
   (R) and sucrose-based beverages used in the study. The study has been
   supported by grants HENUFOOD from the University of Valencia and
   PI15/01424, PI13/1025 and PI13/0073 from the Fund for Health Research
   (FIS) and co-funded by the European Regional Development Fund of the
   European Union (FEDER, "A way to build Europe"), UGP-15-220 and
   UGP-15-193 from FISABIO and PROMETEOII2014/035 and GV/2016/169 from the
   Conselleria de Educacion, Investigacion, Cultura y Deporte de la
   Generalitat Valenciana. V. M. Victor is the recipient of a contract from
   the Valencian Regional Ministry of Health and Carlos III Health
   Institute (CES10/030). M. Rocha is the recipient of a Miguel Servet
   contract from FIS (C10/00360). C. Banuls is the recipient of a Sara
   Borrell contract from FIS (CD14/00043).
CR Bañuls C, 2016, CLIN NUTR, V35, P600, DOI 10.1016/j.clnu.2015.05.005
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NR 30
TC 12
Z9 12
U1 0
U2 23
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PY 2016
VL 7
IS 10
BP 4379
EP 4387
DI 10.1039/c6fo01021k
PG 9
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA DZ9XT
UT WOS:000386236000026
PM 27713964
DA 2025-06-11
ER

PT J
AU Chen, YW
   Harris, RA
   Hatahet, Z
   Chou, KM
AF Chen, Yih-Wen
   Harris, Robert A.
   Hatahet, Zafer
   Chou, Kai-ming
TI Ablation of XP-V gene causes adipose tissue senescence and metabolic
   abnormalities
SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF
   AMERICA
LA English
DT Article
DE DNA polymerase eta; obesity; senescence; DNA damage; adipose tissue
ID DNA-POLYMERASE-ETA; OXIDATIVE STRESS; OBESITY; CANCER; SURVIVAL;
   PROTEIN; DAMAGE; P53; SUSCEPTIBILITY; HYPERMUTATION
AB Obesity and the metabolic syndrome have evolved to be major health issues throughout the world. Whether loss of genome integrity contributes to this epidemic is an open question. DNA polymerase eta (pol eta), encoded by the xeroderma pigmentosum (XP-V) gene, plays an essential role in preventing cutaneous cancer caused by UV radiation-induced DNA damage. Herein, we demonstrate that pol. deficiency in mice (pol eta(-/-)) causes obesity with visceral fat accumulation, hepatic steatosis, hyperleptinemia, hyperinsulinemia, and glucose intolerance. In comparison to WT mice, adipose tissue from pol eta(-/-) mice exhibits increased DNA damage and a greater DNA damage response, indicated by upregulation and/or phosphorylation of ataxia telangiectasia mutated (ATM), phosphorylated H(2)AX (gamma H(2)AX), and poly[ADP-ribose] polymerase 1 (PARP-1). Concomitantly, increased cellular senescence in the adipose tissue from pol eta(-/-) mice was observed and measured by up-regulation of senescence markers, including p53, p16(Ink4a), p21, senescence-associated (SA) beta-gal activity, and SA secretion of proinflammatory cytokines interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-alpha) as early as 4 wk of age. Treatment of pol eta(-/-) mice with a p53 inhibitor, pifithrin-alpha, reduced adipocyte senescence and attenuated the metabolic abnormalities. Furthermore, elevation of adipocyte DNA damage with a high-fat diet or sodium arsenite exacerbated adipocyte senescence and metabolic abnormalities in pol eta(-/-) mice. In contrast, reduction of adipose DNA damage with N-acetylcysteine or metformin ameliorated cellular senescence and metabolic abnormalities. These studies indicate that elevated DNA damage is a root cause of adipocyte senescence, which plays a determining role in the development of obesity and insulin resistance.
C1 [Chen, Yih-Wen; Chou, Kai-ming] Indiana Univ Sch Med, Dept Pharmacol & Toxicol, Indianapolis, IN 46202 USA.
   [Harris, Robert A.] Indiana Univ Sch Med, Richard Roudebush Vet Affairs Med Ctr, Indianapolis, IN 46202 USA.
   [Harris, Robert A.] Indiana Univ Sch Med, Dept Biochem & Mol Biol, Indianapolis, IN 46202 USA.
   [Hatahet, Zafer] Northwestern State Univ Louisiana, Dept Biol & Phys Sci, Natchitoches, LA 71497 USA.
C3 Indiana University System; Indiana University Bloomington; Indiana
   University System; Indiana University Bloomington; US Department of
   Veterans Affairs; Veterans Health Administration (VHA); Richard L.
   Roudebush VA Medical Center; Indiana University System; Indiana
   University Bloomington; University of Louisiana System; Northwestern
   State University of Louisiana
RP Chou, KM (corresponding author), Indiana Univ Sch Med, Dept Pharmacol & Toxicol, Indianapolis, IN 46202 USA.
EM kmchou3@gmail.com
FU NIH [R01 CA 112446]; Veterans Affairs Merit Award
FX We thank Dr. Richard Honkanen (University of South Alabama) for
   suggestions and comments during the study. This study was supported, in
   part, by NIH Grant R01 CA 112446 (to K.-m.C.) and a Veterans Affairs
   Merit Award (to R.A.H.).
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NR 57
TC 64
Z9 71
U1 0
U2 19
PU NATL ACAD SCIENCES
PI WASHINGTON
PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA
SN 0027-8424
J9 P NATL ACAD SCI USA
JI Proc. Natl. Acad. Sci. U. S. A.
PD AUG 18
PY 2015
VL 112
IS 33
BP E4556
EP E4564
DI 10.1073/pnas.1506954112
PG 9
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA CP2WL
UT WOS:000359738300008
PM 26240351
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Hamza, N
   Berke, B
   Cheze, C
   Marais, S
   Lorrain, S
   Abdouelfath, A
   Lassalle, R
   Caries, D
   Gin, H
   Moore, N
AF Hamza, Nawel
   Berke, Benedicte
   Cheze, Catherine
   Marais, Sebastien
   Lorrain, Simon
   Abdouelfath, Abdelilah
   Lassalle, Regis
   Caries, Dominique
   Gin, Henri
   Moore, Nicholas
TI Effect of Centaurium erythraea Rafn, Artemisia
   herba-alba Asso and Trigonella foenum-graecum
   L. on liver fat accumulation in C5713L/6J mice with high-fat
   diet-induced type 2 diabetes
SO JOURNAL OF ETHNOPHARMACOLOGY
LA English
DT Article
DE Type 2 diabetes/therapy/prevention; Non-alcoholic liver steatosis;
   Artemisia herba-alba; Centaurium erythraea; Trigonella foenum-graecum;
   High fat diet; Mice
ID NONALCOHOLIC STEATOHEPATITIS; LIPID-ACCUMULATION; FENUGREEK SEEDS;
   ANTIOXIDANT ACTIVITY; INSULIN-RESISTANCE; METABOLIC SYNDROME; OXIDATIVE
   STRESS; CHLOROGENIC ACID; RATS; DISEASE
AB Ethnopharmacological relevance: Centaurium erythraea Rafn (CE), Artemisia herba-alba Asso (AHA) and Trigonella foenum-graecum L. (TFG) are traditionally used to treat type 2 diabetes in Algeria, previous studies have found that extracts of these plants were effective to treat or prevent experimental diabetes induced by high-fat diet (HFD).
   Aim of the study: Describe the additional effects of these extracts on lipid tissue deposition in HFD.
   Materials and methods: Male C57BL/6J mice were fed with HFD to induce type 2 Diabetes. Groups of mice were given plant extracts orally at 2 g/kg/bodyweight daily for 20 weeks during establishment of diabetes, or for 18 weeks after confirmation of diabetes at the 17th week. Liver and other tissue samples were stained with Oil Red O.
   Results: Liver steatosis was confirmed with HFD. CE, AHA and TFG extracts improved liver steatosis by the end of the preventive (20 weeks) and curative periods (35 weeks). This was most marked for CE extract (p < 0.05), less so with TFG and AHA. No steatosis was found in other tissues.
   Conclusion: CE extract had a clear hepatoprotective effect in this mouse model of diet-induced type 2 diabetes. AHA and TFG had a minimal or no significant effect on steatosis. Beyond its effect as an antidiabetic agent, CE may also be promising to prevent or treat non-alcoholic liver steatosis. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
C1 [Hamza, Nawel; Berke, Benedicte; Cheze, Catherine; Lorrain, Simon; Abdouelfath, Abdelilah; Lassalle, Regis; Moore, Nicholas] Univ Bordeaux, Dept Pharmacol, F-33076 Bordeaux, France.
   [Hamza, Nawel] Univ Freres Mentouri, Dept Nutr, INATAA, Constantine, Algeria.
   [Gin, Henri] CHU Bordeaux, Serv Nutr Diabetol & Malad Metabol, Bordeaux, France.
   [Marais, Sebastien] Univ Bordeaux, Bordeaux Imaging Ctr, CNRS, UMS 3420, F-33076 Bordeaux, France.
   [Caries, Dominique] Univ Bordeaux, CHU Bordeaux, Hop Pellegrin, Unite Pathol Foetoplacentaire, F-33076 Bordeaux, France.
C3 Universite de Bordeaux; Universite Constantine; CHU Bordeaux; Universite
   de Bordeaux; Universite de Bordeaux; Centre National de la Recherche
   Scientifique (CNRS); Institut National de la Sante et de la Recherche
   Medicale (Inserm); CNRS - National Institute for Biology (INSB); CHU
   Bordeaux; Universite de Bordeaux
RP Hamza, N (corresponding author), Univ Bordeaux, Dept Pharmacol, INSERM, U657, Bat 1A,Case 36, F-33076 Bordeaux, France.
EM nawelc2001@yahoo.fr; nicholas.moore@u-bordeaux.fr
RI Moore, Nicholas/B-2368-2013
OI MARAIS, Sebastien/0000-0003-1521-1188; Moore,
   Nicholas/0000-0003-1212-2817
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NR 58
TC 16
Z9 18
U1 1
U2 31
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0378-8741
J9 J ETHNOPHARMACOL
JI J. Ethnopharmacol.
PD AUG 2
PY 2015
VL 171
BP 4
EP 11
DI 10.1016/j.jep.2015.05.027
PG 8
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA CN5KK
UT WOS:000358468000002
PM 26023031
DA 2025-06-11
ER

PT J
AU Kim, TN
   Choi, KM
AF Kim, Tae Nyun
   Choi, Kyung Mook
TI The Implications of Sarcopenia and Sarcopenic Obesity on Cardiometabolic
   Disease
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Article
DE SARCOPENIC OBESITY; CARDIOMETABOLIC DISEASE; SARCOPENIA; VISCERAL
   OBESITY
ID CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; SKELETAL-MUSCLE;
   ADIPOSE-TISSUE; VISCERAL FAT; ARTERIAL STIFFNESS; INSULIN-RESISTANCE;
   SATELLITE CELLS; OLDER-ADULTS; BODY-MASS
AB The important changes in body composition associated with aging are a decline in skeletal muscle mass and an increase in body fat. Body fat distribution also changes with age; subcutaneous fat decreases and visceral abdominal fat increase, which contributes to numerous cardiometabolic diseases (CMDs) such as type 2 diabetes, dyslipidemia, and cardiovascular disease (CVD). Sarcopenia often accompanied by an increase in body fat and vice versa, a scenario termed sarcopenic obesity (SO), which might lead to the cumulative risk of both sarcopenia and obesity. However, there is still no consensus regarding the definition and consequences of SO. The lack of a unified definition for SO might contribute to inconsistent findings about the association of SO with CMD. Complex etiologies are associated with development of SO. A vicious cycle between the loss of muscle and the accumulation of ectopic fat might be associated with CMD via an intricate interplay of factors including proinflammatory cytokines, oxidative stress, mitochondrial dysfunction, insulin resistance, dietary energy, physical activity, mitochondrial dysfunction, and other factors that have yet to be identified. Moreover, recent epidemiological studies suggest that SO is related to CVD and mortality. This review focuses on the current literature with regard to the association between sarcopenia, dynapenia, and obesity, as well as their implications for CMD. The ultimate goal of this Prospects is to encourage conduct of well-designed future studies that elucidate the relationship among sarcopenia, SO, and CMD. J. Cell. Biochem. 116: 1171-1178, 2015. (c) 2014 Wiley Periodicals, Inc.
C1 [Kim, Tae Nyun; Choi, Kyung Mook] Korea Univ, Coll Med, Dept Internal Med, Div Endocrinol & Metab, Seoul 136705, South Korea.
   [Kim, Tae Nyun] Inje Univ, Dept Internal Med, Cardiovasc & Metab Dis Ctr, Busan, South Korea.
C3 Korea University; Korea University Medicine (KU Medicine); Inje
   University
RP Choi, KM (corresponding author), Korea Univ, Guro Hosp, Dept Internal Med, Div Endocrinol & Metab, 80 Guro Dong, Seoul 152050, South Korea.
EM medica7@gmail.com
RI Kim, Tae/AAV-5521-2020; Choi, Kyung/C-4195-2018
OI Kim, Tae Nyun/0000-0001-6568-2469; Choi, Kyung Mook/0000-0001-6175-0225
FU Korean Health Technology R&D Project, Ministry of Health & Welfare,
   Republic of Korea [HI14C0133]; Priority Research Centers Program through
   the NRF - Ministry of Education, Science, and Technology, Republic of
   Korea [2010-0020224]
FX Grant sponsor: Korean Health Technology R&D Project, Ministry of Health
   & Welfare, Republic of Korea; Grant number: HI14C0133; Grant sponsor:
   Priority Research Centers Program through the NRF funded by the Ministry
   of Education, Science, and Technology, Republic of Korea; Grant number:
   2010-0020224
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NR 54
TC 165
Z9 176
U1 0
U2 47
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0730-2312
EI 1097-4644
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PD JUL
PY 2015
VL 116
IS 7
BP 1171
EP 1178
DI 10.1002/jcb.25077
PG 8
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA CI0VT
UT WOS:000354457900002
PM 25545054
DA 2025-06-11
ER

PT J
AU Tanguy, S
   Toufektsian, MC
   Grauzam, S
   de Leiris, J
   Ghezzi, C
   Boucher, F
   Sulpice, T
AF Tanguy, Stephane
   Toufektsian, Marie-Claire
   Grauzam, Stephane
   de Leiris, Joel
   Ghezzi, Catherine
   Boucher, Francois
   Sulpice, Thierry
TI Cardiac Dysfunction in Rats with Dietary-Induced Insulin Resistance
   Associated with Pharmacologically-induced Dyslipidemia
SO CURRENT PHARMACEUTICAL DESIGN
LA English
DT Article
DE Dyslipidemia; insulin-resistance; cardiac dysfunction; inflammation
ID METABOLIC SYNDROME; DIABETIC HEART; CARDIOVASCULAR-DISEASE; TNF-ALPHA;
   MODEL; HYPERLIPIDEMIA; COMPLICATIONS; INFARCTION; IMPACT
AB Metabolic disorders such as insulin resistance (IR) and dyslipidemia (DL) might contribute to the induction of diabetic cardiomyopathy (DCM). However, few relevant animal models are currently available for studying the time-course of DCM and evaluating experimental therapeutics. The present study proposes a rodent model of dietary-induced IR combined or not with DL in order to investigate the impact of chronic IR and DL on in vivo myocardial function. Male rats were fed a western-type diet (65% fat; 15% fructose; WD). DL was induced by combining the western diet with i.p. injections of a nonionic surface-active agent (P-407; 0.2 mg/kg, 3 times/wk; P-407). A chow diet was used as control. At 11 and 14 weeks, cardiac function was assessed by echocardiography. Fasting blood glucose increased in WD group while plasma lipids markedly accumulated in P-407 treated rats. Echocardiographic data showed no significant difference in cardiac geometry under basal conditions. Diastolic dysfunction was evidenced at 14 weeks by a significant decrease in E/A ratio in the P-407 group. Moreover, fractional shortening was significantly depressed under dobutamine stress in WD group at 14 weeks whereas systolic dysfunction appeared as early as 11 weeks and worsened at 14 weeks in P-407 animals. Finally, myocardial TNF-alpha tissue content increased in P-407 group. In conclusion, DL exacerbated cardiac lipotoxicity and functional complications associated with IR. This experimental model of combined IR and DL closely mimics the main clinical manifestations of DCM and might therefore constitute a useful tool for the evaluation of pharmacological treatments.
C1 [Tanguy, Stephane; Toufektsian, Marie-Claire; Grauzam, Stephane; de Leiris, Joel; Boucher, Francois] Univ Grenoble 1, CNRS TIMC IMAG UMR5525, Equipe PRETA, F-38041 Grenoble, France.
   [Ghezzi, Catherine] Univ Grenoble 1, INSERM Lab Radiopharmaceut Bioclin, UMR S 1039, F-38041 Grenoble, France.
   [Sulpice, Thierry] Physiogenex SAS, Toulouse, France.
C3 Communaute Universite Grenoble Alpes; Universite Grenoble Alpes (UGA);
   Centre National de la Recherche Scientifique (CNRS); CNRS - Institute
   for Engineering & Systems Sciences (INSIS); Institut National de la
   Sante et de la Recherche Medicale (Inserm); Communaute Universite
   Grenoble Alpes; Universite Grenoble Alpes (UGA)
RP Boucher, F (corresponding author), Univ Grenoble 1, Lab TIMC IMAG, CNRS UMR5525, Batiment Jean Roget Domaine Merci, F-38706 La Tronche, France.
EM Francois.Boucher@ujf-grenoble.fr
RI GHEZZI, Catherine/M-5185-2014; Boucher, François/M-5937-2014; ,
   stephane/LWI-4124-2024
OI , stephane/0000-0002-9532-9145; Catherine, GHEZZI/0000-0001-6840-400X
FU Physiogenex SAS; Universite Joseph Fourier
FX This study was supported by Physiogenex SAS and by Universite Joseph
   Fourier.
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NR 33
TC 4
Z9 4
U1 0
U2 10
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1381-6128
EI 1873-4286
J9 CURR PHARM DESIGN
JI Curr. Pharm. Design
PD DEC
PY 2013
VL 19
IS 39
BP 6906
EP 6911
DI 10.2174/138161281939131127122054
PG 6
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 262JL
UT WOS:000327730800010
PM 23590153
DA 2025-06-11
ER

PT J
AU Salamin, G
   Pelletier, C
   Poirier, P
   Després, JP
   Bertrand, O
   Alméras, N
   Costerousse, O
   Brassard, P
AF Salamin, Guillaume
   Pelletier, Claudine
   Poirier, Paul
   Despres, Jean-Pierre
   Bertrand, Olivier
   Almeras, Natalie
   Costerousse, Olivier
   Brassard, Patrice
TI Impact of Visceral Obesity on Cardiac Parasympathetic Activity in Type 2
   Diabetics after Coronary Artery Bypass Graft Surgery
SO OBESITY
LA English
DT Article
ID AUTONOMIC NERVOUS-SYSTEM; HEART-RATE-VARIABILITY; ABDOMINAL OBESITY;
   WEIGHT-LOSS; ATRIAL-FIBRILLATION; METABOLIC SYNDROME; EPICARDIAL FAT;
   ADIPOSE-TISSUE; RISK; STRESS
AB Objective: The association between adiposity and heart rate variability (HRV) in patients with type 2 diabetes (T2D) after coronary artery bypass graft surgery (CABG) is not well documented. We evaluated the associations between indices of adiposity and HRV in patients with T2D with CABG and quantified the relationships of the volume of visceral (VVAT) and subcutaneous adipose tissue (VSAT) to HRV.
   Design and Methods: One hundred and thirty-five men with T2D who underwent CABG participated in this study. HRV, BMI, waist circumference (WC), VVAT, and VSAT were measured. Correlations between indices of HRV and adiposity were evaluated and predictors of HRV modulation were identified. Patients were then divided into quartiles of VVAT and VSAT to further evaluate the influence of adiposity on HRV.
   Results: Subjects were 65 +/- 7 years old (mean +/- SD) with a BMI of 30 +/- 4 kg/m(2) and a WC of 105 +/- 10 cm. BMI (r = -0.19) and WC (r = -0.25) were inversely correlated with low frequencies. VVAT correlated negatively with SD normal-to normal (SDNN) (r = -0.22, P < 0.01), indices of cardiac parasympathetic activity [rMSSD (r = -0.27), NN50 (r = -0.22), pNN50 (r = -0.26; all P < 0.05], and with low (r = -0.37) and high frequencies (r = -0.20; all P < 0.01). Patients with the lowest VVAT had the highest cardiac parasympathetic activity (P < 0.05). VVAT remained the best predictor of cardiac parasympathetic activity after adjustments for confounding parameters (P < 0.01).
   Conclusion: An increase in visceral adiposity, not BMI, seems to be associated with lower HRV in patients with T2D who had a CABG procedure.
C1 [Salamin, Guillaume; Pelletier, Claudine; Despres, Jean-Pierre; Brassard, Patrice] Univ Laval, Fac Med, Dept Kinesiol, Quebec City, PQ G1K 7P4, Canada.
   [Salamin, Guillaume; Pelletier, Claudine; Poirier, Paul; Despres, Jean-Pierre; Bertrand, Olivier; Almeras, Natalie; Costerousse, Olivier; Brassard, Patrice] Inst Univ Cardiol & Pneumol Quebec, Ctr Rech, Quebec City, PQ, Canada.
   [Poirier, Paul] Univ Laval, Fac Pharm, Quebec City, PQ, Canada.
C3 Laval University; Laval University; Laval University Hospital; Laval
   University
RP Brassard, P (corresponding author), Univ Laval, Fac Med, Dept Kinesiol, Quebec City, PQ G1K 7P4, Canada.
EM patrice.brassard@kin.ulaval.ca
RI Brassard, Patrice/H-6115-2019; Poirier, Paul/KFS-2253-2024
OI Brassard, Patrice/0000-0002-6254-5044
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NR 40
TC 9
Z9 10
U1 0
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1930-7381
EI 1930-739X
J9 OBESITY
JI Obesity
PD AUG
PY 2013
VL 21
IS 8
BP 1578
EP 1585
DI 10.1002/oby.20089
PG 8
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 206LE
UT WOS:000323521500012
PM 23585195
OA Bronze
DA 2025-06-11
ER

PT J
AU Kitada, M
   Kume, S
   Kanasaki, K
   Takeda-Watanabe, A
   Koya, D
AF Kitada, Munehiro
   Kume, Shinji
   Kanasaki, Keizo
   Takeda-Watanabe, Ai
   Koya, Daisuke
TI Sirtuins as Possible Drug Targets in Type 2 Diabetes
SO CURRENT DRUG TARGETS
LA English
DT Article
DE Sirtuins; SIRT1; SIRT3; SIRT6; type 2 diabetes; insulin resistance
ID FATTY-ACID OXIDATION; NF-KAPPA-B; STIMULATED INSULIN-SECRETION;
   SMALL-MOLECULE ACTIVATORS; CALORIE RESTRICTION; GENE-EXPRESSION;
   MITOCHONDRIAL-FUNCTION; SIRT1 DEACETYLATES; METABOLIC SYNDROME;
   ENERGY-METABOLISM
AB The rising incidence of type 2 diabetes mellitus (T2DM) is a major public health problem in industrialized countries, and new therapeutic strategies to prevent T2DM are urgently needed worldwide. It is well known that calorie restriction (CR) can retard the aging process in organisms ranging from yeast to rodents and delay the onset of numerous age-related diseases, including diabetes. Molecules that mimic CR metabolically may therefore represent new therapeutic targets for T2DM. Sirtuin1 (SIRT1), the mammalian homolog of Sir2, was originally identified as a NAD(+)-dependent histone deacetylase, and its activity is closely associated with longevity under CR. Growing evidence suggests that SIRT1 regulates glucose-lipid metabolism through its deacetylase activity for many known substrates and has many roles in the metabolic pathway through its direct or indirect involvement in insulin signaling in insulin-sensitive organs, including adipose tissue, liver and skeletal muscle. In addition, SIRT1 regulates insulin secretion, and adiponectin production, inflammation, gluconeogenesis, circadian rhythms and oxidative stress, which together contribute to the development of insulin resistance. Moreover, the overexpression of SIRT1 and several SIRT1 activators have beneficial effects on glucose homeostasis and insulin sensitivity in diabetic animal models and humans. Therefore, SIRT1 may represent a new therapeutic target for the prevention of diseases related to insulin resistance and T2DM. In addition, SIRT3 and SIRT6 play crucial roles in glucose and lipid metabolism. In this review, we summarize the current understanding of the biological functions of SIRT1, SIRT3 and SIRT6 in metabolism and discuss their potential role as therapeutic targets in T2DM.
C1 [Kitada, Munehiro; Kanasaki, Keizo; Takeda-Watanabe, Ai; Koya, Daisuke] Kanazawa Med Univ, Kanazawa, Ishikawa, Japan.
   [Kume, Shinji] Shiga Univ Med Sci, Shiga, Japan.
C3 Kanazawa Medical University; Shiga University of Medical Science
RP Koya, D (corresponding author), Kanazawa Med Univ, Div Diabetol & Endocrinol, Kahoku, Ishikawa 9200293, Japan.
EM koya0516@kanazawa-med.ac.jp
RI å®—å¼˜, åŒ—ç”°/AAD-8655-2019; Koya, Daisuke/J-3257-2014
FU Novo Nordisk Pharma; Kanazawa Medical University [S2012-4, PR2012-05,
   C2012-1, SR2012-06]; Japanese Society of Anti-Aging Medicine;  [2459
   1218]
FX This work was supported by a Grant from Novo Nordisk Pharma, a
   Grant-in-Aid for Scientific Research (C) (2459 1218), a Grant for
   Promoted Research from Kanazawa Medical University (S2012-4) to M.
   Kitada, a Grant for Precursory Alumni Research (B) from Kanazawa Medical
   University to A. Takeda-Watanabe (PR2012-05), Collaborative Research
   (C2012-1) and Specially Promoted Research from Kanazawa Medical
   University (SR2012-06) and the 4th Annual Research Award Grant of
   Japanese Society of Anti-Aging Medicine to D. Koya.
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NR 107
TC 79
Z9 86
U1 0
U2 50
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1389-4501
EI 1873-5592
J9 CURR DRUG TARGETS
JI Curr. Drug Targets
PD JUN
PY 2013
VL 14
IS 6
BP 622
EP 636
DI 10.2174/1389450111314060002
PG 15
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 140XE
UT WOS:000318689000002
PM 23445543
DA 2025-06-11
ER

PT J
AU Shen, WL
   Tian, C
   Chen, H
   Yang, Y
   Zhu, DL
   Gao, PJ
   Liu, JK
AF Shen, Weili
   Tian, Chuan
   Chen, Hong
   Yang, Ying
   Zhu, Dingliang
   Gao, Pingjin
   Liu, Jiankang
TI Oxidative stress mediates chemerin-induced autophagy in endothelial
   cells
SO FREE RADICAL BIOLOGY AND MEDICINE
LA English
DT Article
DE Reactive oxygen species; Autophagy; Chemerin; Angiogenesis; Free
   radicals
ID ACTIVATED PROTEIN-KINASE; ADIPOSE-TISSUE DEVELOPMENT; DENDRITIC CELLS;
   MODULATES ADIPOGENESIS; INDUCED ANGIOGENESIS; SIGNALING CASCADES;
   GENE-EXPRESSION; PROTECTIVE ROLE; UP-REGULATION; IN-VITRO
AB Chemerin is a novel adipokine associated with obesity and metabolic syndrome. Previous studies indicate that chemerin may also function as a stimulator of angiogenesis. However, the underlying mechanism of its regulatory role in angiogenesis remains largely unknown. In this study, we determined the role of autophagy in chemerin-induced angiogenesis. Treatment of human aorta endothelial cells (HAECs) with chemerin increased the generation of mitochondrial reactive oxygen species (ROS) concurrent with the induced, time-dependent expression of LC3II and upregulation of the autophagy-related genes beclin-1, Atg7, and Atg12-Atg5. Knockdown of chemerin receptor 23 (ChemR23) by shRNA or treatment with the mitochondria-targeted antioxidant Mito-TEMPO decreased the chemerin-associated ROS generation and abolished the upregulation of autophagy-related genes. Furthermore, chemerin treatment of HAECs augmented AMP-activated protein kinase-alpha (AMPK alpha) activity and acetyl-CoA carboxylase phosphorylation and reduced phosphorylation of the mammalian target of rapamycin, ribosomal protein S6 kinase-1, and eukaryotic initiation factor 4E-binding protein 1, which were blocked by coadministration of Mito-TEMPO or shRNA-mediated knockdown of AMPK alpha. Analysis of the HAECs revealed that inhibition of autophagy by Mito-TEMPO or shRNA against ChemR23, AMPK alpha, and beclin-1 impaired chemerin-induced tube formation and cell proliferation. These studies show that mitochondrial ROS are important for autophagy in chemerin-induced angiogenesis and that targeting autophagy may provide an important new tool for treating cardiovascular disease. (c) 2012 Elsevier Inc. All rights reserved.
C1 [Shen, Weili; Zhu, Dingliang; Gao, Pingjin] Shanghai Jiao Tong Univ, Ruijin Hosp, State Key Lab Med Genom, Shanghai Key Lab Vasc Biol,Sch Med, Shanghai 200025, Peoples R China.
   [Shen, Weili; Zhu, Dingliang; Gao, Pingjin] Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp, Dept Hypertens, Shanghai 200025, Peoples R China.
   [Shen, Weili; Tian, Chuan] Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Shanghai, Peoples R China.
   [Chen, Hong] Shanghai Jiao Tong Univ, Sch Med, Dept Pharmacol, Shanghai 200025, Peoples R China.
   [Yang, Ying] Shanghai Jiao Tong Univ, Dept Endocrine & Metab Dis, Shanghai Inst Endocrine & Metab Dis,Ruijin Hosp, Shanghai Clin Ctr Endocrine & Metab Dis,Sch Med, Shanghai 200025, Peoples R China.
   [Liu, Jiankang] Xi An Jiao Tong Univ, Sch Life Sci & Technol, Inst Mitochondrial Biol & Med, Key Lab Biomed Informat Engn,Minist Educ, Xian 710049, Peoples R China.
C3 Chinese Academy of Sciences; Shanghai Jiao Tong University; Shanghai
   Jiao Tong University; Chinese Academy of Sciences; Shanghai Jiao Tong
   University; Shanghai Jiao Tong University; Ministry of Education -
   China; Xi'an Jiaotong University
RP Shen, WL (corresponding author), Shanghai Jiao Tong Univ, Dept Hypertens, Shanghai Inst Hypertens, 197 Ruijin 2nd Rd, Shanghai 200025, Peoples R China.
EM wlshen@sibs.ac.cn; j.liu@mail.xjtu.edu
RI Liu, Jiankang/A-1610-2011
OI Shen, Weili/0000-0002-3088-8245
FU National Natural Science Foundation of China [30871002, 81070325,
   30971154, 31171099]; Shanghai Science and Technology Committee, Shanghai
   [10DZ1976000]; National Basic Research Program of China [2011CB503905,
   2012AA02A516, 2009CB521907]
FX This study was supported by grants from the National Natural Science
   Foundation of China (30871002, 81070325, 30971154, and 31171099), grants
   from the Shanghai Science and Technology Committee, Shanghai
   (10DZ1976000), and the National Basic Research Program of China
   (2011CB503905, 2012AA02A516, and 2009CB521907).
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NR 65
TC 76
Z9 86
U1 0
U2 47
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0891-5849
J9 FREE RADICAL BIO MED
JI Free Radic. Biol. Med.
PD FEB
PY 2013
VL 55
BP 73
EP 82
DI 10.1016/j.freeradbiomed.2012.11.011
PG 10
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 090WB
UT WOS:000315009600009
PM 23195684
DA 2025-06-11
ER

PT J
AU Nagayasu, S
   Suzuki, S
   Yamashita, A
   Taniguchi, A
   Fukushima, M
   Nakai, Y
   Nin, K
   Watanabe, N
   Nagasaka, S
   Yabe, D
   Nishimura, F
AF Nagayasu, Shintaro
   Suzuki, Shigeki
   Yamashita, Akiko
   Taniguchi, Ataru
   Fukushima, Mitsuo
   Nakai, Yoshikatsu
   Nin, Kazuko
   Watanabe, Naoya
   Nagasaka, Shoichiro
   Yabe, Daisuke
   Nishimura, Fusanori
TI Smoking and adipose tissue inflammation suppress leptin expression in
   Japanese obese males: potential mechanism of resistance to weight loss
   among Japanese obese smokers
SO TOBACCO INDUCED DISEASES
LA English
DT Article
DE Leptin; Smoking; Low-grade inflammation; Nicotine; ICAM-1
ID ENDOPLASMIC-RETICULUM STRESS; METABOLIC SYNDROME; CIGARETTE-SMOKING;
   PLAYS
AB Background: The effect of smoking on leptin regulation is controversial. Smoking may induce low-grade inflammation. Recent series of studies indicated the critical role of macrophage migration in the establishment of adipose tissue inflammation. In this study, we aimed to see the effects of smoking and inflammation on leptin regulation both at cellular and epidemiological levels.
   Methods: We compared the concentration of inflammatory markers and serum leptin levels among Japanese male subjects. Additionally, leptin and intercellular adhesion molecule (ICAM) -1 gene expression was assessed in adipocytes co-cultured with or without macrophages in the presence or absence of nicotine and/or lipopolysaccharide (LPS).
   Results: In subjects with BMI below 25 kg/m(2), both WBC counts and soluble-ICAM-1 levels are significantly higher in smokers than in non-smokers. However, leptin concentration did not differ according to smoking status. However, in subjects with BMI over 25 kg/m(2), smokers exhibited significantly lower serum leptin level as well as higher WBC counts and s-ICAM-1 concentration as compared with non-smokers. Leptin gene expression was markedly suppressed in adipocytes co-cultured with macrophages than in adipocyte culture alone. Furthermore, nicotine further suppressed leptin gene expression. ICAM-1 gene expression was markedly up-regulated in adipocytes co-cultured with macrophages when stimulated with LPS.
   Conclusions: Adipose tissue inflammation appears to down-regulate leptin expression in adipose tissues. Nicotine further suppresses leptin expression. Thus, both smoking and inflammation may diminish leptin effect in obese subjects. Therefore, obese, but not normal weight, smokers might be more resistant to weight loss than nonsmokers.
C1 [Nagayasu, Shintaro; Suzuki, Shigeki; Yamashita, Akiko; Nishimura, Fusanori] Hiroshima Univ, Grad Sch Biomed Sci, Dept Dent Sci Hlth Promot, Minami Ku, Hiroshima 7348553, Japan.
   [Taniguchi, Ataru] Kyoto Prevent Med Ctr, Div Diabet & Endocrinol, Nakagyo Ku, Kyoto 6048091, Japan.
   [Fukushima, Mitsuo] Okayama Prefectural Univ, Div Clin Nutr & Internal Med, Soja City, Okayama 7191197, Japan.
   [Nakai, Yoshikatsu] Kyoto Inst Hlth Sci, Nakagyo Ku, Kyoto 6040845, Japan.
   [Nin, Kazuko] Kyoto Univ, Grad Sch Med, Sakyo Ku, Kyoto 6068501, Japan.
   [Watanabe, Naoya] Yodogawa Christians Hosp, Hlth Care & Promot Ctr, Higashiyodogawa Ku, Osaka 5330032, Japan.
   [Nagasaka, Shoichiro] Jichi Med Univ, Dept Med, Div Endocrinol & Metab, Shimotsuke 3290498, Japan.
   [Yabe, Daisuke] Kansai Elect Power Hosp, Div Diabet Clin Nutr & Endocrinol, Fukushima Ku, Osaka 5530003, Japan.
C3 Hiroshima University; Okayama Prefectural University; Kyoto University;
   Jichi Medical University
RP Nishimura, F (corresponding author), Hiroshima Univ, Grad Sch Biomed Sci, Dept Dent Sci Hlth Promot, Minami Ku, 1-2-3 Kasumi, Hiroshima 7348553, Japan.
EM fusanori@hiroshima-u.ac.jp
RI Yabe, Daisuke/J-6682-2014
OI Yabe, Daisuke/0000-0002-5334-7687; Suzuki, Shigeki/0000-0003-0888-4050
FU Japan Society for the Promotion of Science [21390556, 22792086,
   22390401]; Ministry of Education, Culture, Sports, Science and
   Technology; Grants-in-Aid for Scientific Research [22390401, 23792176,
   21390556, 22792086] Funding Source: KAKEN
FX This work was supported, in part, by a Grant-in-Aid (No. 21390556,
   22792086, 22390401) from the Japan Society for the Promotion of Science
   and from the Academic Frontier Project for Private Universities:
   matching fund subsidy from the Ministry of Education, Culture, Sports,
   Science and Technology, 2007-2011.
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NR 23
TC 18
Z9 20
U1 0
U2 2
PU EUROPEAN PUBLISHING
PI HERAKLION
PA SCIENCE & TECHNOLGY PARK CRETE, (STEP-C), N PLASTIRA 100, VASSILIKA
   VOUTWN, HERAKLION, CRETE 00000, GREECE
SN 1617-9625
J9 TOB INDUC DIS
JI Tob. Induc. Dis.
PD FEB 28
PY 2012
VL 10
AR 3
DI 10.1186/1617-9625-10-3
PG 7
WC Substance Abuse; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Substance Abuse; Public, Environmental & Occupational Health
GA 254WA
UT WOS:000327198300002
PM 22373492
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Anatskaya, OV
   Sidorenko, NV
   Vinogradov, AE
   Beyer, TV
AF Anatskaya, Olga V.
   Sidorenko, Nina V.
   Vinogradov, Alexander E.
   Beyer, Tamara V.
TI Impact of neonatal cryptosporidial gastroenteritis on epigenetic
   programming of rat hepatocytes
SO CELL BIOLOGY INTERNATIONAL
LA English
DT Article
DE cryptosporidiosis; diarrhea; polyploidy; protein content; critical
   periods of liver development
ID CELL POLYPLOIDIZATION; GENE-EXPRESSION; LIVER; GROWTH; HEART;
   DIFFERENTIATION; IDENTIFICATION; ADAPTATION; DISEASE; INFANT
AB Inflammation, malnutrition and growth retardation during critical time-windows of development play a powerful role in ontogenetic programming of the life-long risk to many adult diseases (including metabolic syndrome, obesity and diabetes). Cellular mechanisms and the accurate timing and duration of critical periods for the liver remain obscure. To resolve this problem, we developed a postnatal suckling-weanling rat model of mild, moderate, and acute gastroenteritis challenged by a protozoan parasitic spread throughout the whole world, namely Cryptosporidium parvum. The physiological state of the liver was evaluated by hepatocyte ploidy and protein content that were measured by cytophotometry and image analysis on isolated cells. Hepatocyte ploidy is known to irreversibly increase after stress and is associated with the decrease in liver physiological capacity. Hepatocyte hypertrophy reflects cell functional loading. From our results, cryptosporidiosis is able to provoke a burst in premature hepatocyte polyploidization and hypertrophy (in proportion to parasitic load), and thus plays an important role in epigenetic programming of hepatocyte structure and function. We revealed two sensitive periods in liver growth. The first period (the less sensitive) covers the time before the establishment of homoiothermy, i.e. 6-9 days after birth. The second period (the more sensitive) covers the time of weaning when the change of type of nutrition and the peak of hepatocyte polyploidization and differentiation occurs. Thus, our data provide direct evidence that phenomenon of ontogenetic programming is reflected at the cellular level. (c) 2007 International Federation for Cell Biology. Published by Elsevier Ltd. All rights reserved.
C1 Russian Acad Sci, Inst Cytol, Dept Struct & Funct Genom, St Petersburg 194064, Russia.
C3 Russian Academy of Sciences; St. Petersburg Scientific Centre of the
   Russian Academy of Sciences; Institute of Cytology RAS
RP Anatskaya, OV (corresponding author), Russian Acad Sci, Inst Cytol, Dept Struct & Funct Genom, 4 Tikhoretsky Ave, St Petersburg 194064, Russia.
EM anatskaya@mail.cytspb.rssi.ru
RI Vinogradov, Alexander/R-3923-2016; Anatskaya, Olga/R-4042-2016
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NR 36
TC 18
Z9 19
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1065-6995
EI 1095-8355
J9 CELL BIOL INT
JI Cell Biol. Int.
PD APR
PY 2007
VL 31
IS 4
BP 420
EP 427
DI 10.1016/j.cellbi.2007.01.028
PG 8
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA 159TV
UT WOS:000245890800014
PM 17331745
DA 2025-06-11
ER

PT J
AU Idris, I
   Thomson, GA
   Sharma, JC
AF Idris, I
   Thomson, GA
   Sharma, JC
TI Diabetes mellitus and stroke
SO INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
LA English
DT Review
DE diabetes; stroke; stress hyperglycaemia; pathogenesis; prevention;
   carotid endatterectomy
ID CORONARY-HEART-DISEASE; BODY-FAT DISTRIBUTION; LOW-DOSE ASPIRIN;
   RISK-FACTORS; ISCHEMIC-STROKE; BLOOD-PRESSURE; CAROTID-ENDARTERECTOMY;
   MYOCARDIAL-INFARCTION; CARDIOVASCULAR EVENTS; HYPERTENSIVE PATIENTS
AB The aim of this article was to describe (i) the epidemiology and outcomes of stroke relating to diabetes; (ii) the pathophysiology of diabetes as a risk factor for stroke; (iii) the management of acute stroke in patients with diabetes; (iv) the evidence of primary and secondary prevention of stroke in patients with diabetes; and (v) the risk of new-onset diabetes using older ant1hypertensive agents.
   The combination of diabetes and stroke disease is a major cause of morbidity and mortality worldwide. Evidence from large clinical trials performed in patients with diabetes supports the need for aggressive and early intervention to target patients' cardiovascular (CV) risks in order to prevent the onset, recurrence and progression of acute stroke. Identification of at-risk patients with diabetes and metabolic syndrome has also allowed the delivery of early and effective intervention to reduce stroke risks, while active treatment during the acute phase of stroke will reduce long-term neurological and functional deficits. While the ongoing debate on the risk benefits of different anti hypertensive, lipid-lowering and antiplatelet agents should not detract clinicians from pursuing aggressive CV risk reduction, the application of evidence-based medicine specifically in patients with diabetes will facilitate the use of appropriate agents to improve clinical outcomes. The overall management of patients with diabetes and acute stroke or at risk of secondary stroke should also include multifactorial intervention that not only targets patient's CV risk but also includes behavioural, lifestyle and, where appropriate, surgical intervention.
C1 Sherwood Forest Hosp NHS Trust, John Pease Diabet Ctr, Sutton In Ashfield NG17 4JL, Notts, England.
RP Sherwood Forest Hosp NHS Trust, John Pease Diabet Ctr, Mansfield Rd, Sutton In Ashfield NG17 4JL, Notts, England.
EM iidris@aol.com
RI Thomson, George/K-8882-2019
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NR 87
TC 85
Z9 92
U1 0
U2 10
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1368-5031
EI 1742-1241
J9 INT J CLIN PRACT
JI Int. J. Clin. Pract.
PD JAN
PY 2006
VL 60
IS 1
BP 48
EP 56
DI 10.1111/j.1368-5031.2006.00682.x
PG 9
WC Medicine, General & Internal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Pharmacology & Pharmacy
GA 011PB
UT WOS:000235279500012
PM 16409428
DA 2025-06-11
ER

PT J
AU Schreyer, S
   Ledwig, D
   Rakatzi, I
   Klöting, I
   Eckel, J
AF Schreyer, S
   Ledwig, D
   Rakatzi, I
   Klöting, I
   Eckel, J
TI Insulin receptor substrate-4 is expressed in muscle tissue without
   acting as a substrate for the insulin receptor
SO ENDOCRINOLOGY
LA English
DT Article
ID TYROSINE PHOSPHORYLATION; VENTRICULAR CARDIOMYOCYTES; GLUCOSE-TRANSPORT;
   HUMAN NEUTROPHILS; SKELETAL-MUSCLE; PROTEIN; RATS; IRS-1; CELLS; SYSTEM
AB Insulin receptor substrate (IRS) proteins represent key elements of the insulin-signaling cascade. IRS-4 is the most recently characterized member of the IRS family with an undefined in vivo function. In contrast to IRS-1 and IRS-2, IRS-4 exhibits a limited tissue expression, and IRS-4 protein has not been detected in any mouse or primary human tissue so far. The purpose of the present study was to analyze the expression of IRS-4 in rat muscle and human skeletal muscle cells and assess involvement of IRS-4 in initial insulin signaling. Using immunoblotting and immunoprecipitation, the specific expression of IRS-4 protein could be demonstrated in rat soleus and cardiac muscle and human skeletal muscle cells, but it was not significantly detectable in quadriceps and gastrocnemius. A prominent down-regulation of IRS-4 was observed in heart and soleus muscle of WOKW rats, an animal model of the metabolic syndrome. In human skeletal muscle cells, both IRS-1 and IRS-2 are rapidly phosphorylated on tyrosine in response to insulin, whereas essentially no tyrosine phosphorylation of IRS-4 was observed in response to both insulin and IGF-I. Instead, a 2-fold increase in IRS-4 tyrosine phosphorylation was observed in myocytes subjected to osmotic stress. In conclusion, IRS-4 protein is expressed in heart and skeletal muscle in a fiber type specific fashion. Our data suggest that IRS-4 does not function as a substrate of the insulin and the IGF-I receptor in primary muscle cells but may be involved in nonreceptor tyrosine kinase signaling.
C1 German Diabetes Res Inst, Dept Clin Biochem & Pathobiochem, D-40225 Dusseldorf, Germany.
   Univ Greifswald, Inst Pathophysiol, D-17495 Karlsburg, Germany.
C3 Universitat Greifswald
RP Eckel, J (corresponding author), German Diabetes Res Inst, Dept Clin Biochem & Pathobiochem, Aufm Hennekamp 65, D-40225 Dusseldorf, Germany.
OI Eckel, Juergen/0000-0003-3645-5288
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NR 37
TC 23
Z9 24
U1 0
U2 0
PU ENDOCRINE SOC
PI BETHESDA
PA 4350 EAST WEST HIGHWAY SUITE 500, BETHESDA, MD 20814-4110 USA
SN 0013-7227
J9 ENDOCRINOLOGY
JI Endocrinology
PD APR
PY 2003
VL 144
IS 4
BP 1211
EP 1218
DI 10.1210/en.2002-220723
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 666QX
UT WOS:000182188900011
PM 12639902
OA Bronze
DA 2025-06-11
ER

PT J
AU Wong, SK
AF Wong, Sok Kuan
TI Effects of chloroquine and hydroxychloroquine on bone health (Review)
SO MOLECULAR MEDICINE REPORTS
LA English
DT Review
DE BMD; bone microstructure; CQ; fracture; HCQ; osteoporosis
ID ALPHA-INDUCED APOPTOSIS; OSTEOGENIC DIFFERENTIATION;
   RHEUMATOID-ARTHRITIS; MINERAL DENSITY; LYSOSOMAL PH; IN-VITRO;
   AUTOPHAGY; OSTEOCLASTOGENESIS; OSTEOPOROSIS; INHIBITION
AB Chloroquine (CQ) and hydroxychloroquine (HCQ), which were initially used to treat malaria, are now also used to treat autoimmune and inflammatory diseases, which have gained notoriety during the coronavirus-19 pandemic. The emerging uses of CQ and HCQ in cancer therapy, metabolic syndrome and bone disorders highlight their broad clinical potential. Patients with autoimmune and inflammatory conditions have a higher risk of suboptimal bone health because of chronic inflammation, immune dysregulation and medication use. In the present review, the use of CQ and HCQ in bone research was explored, particularly in terms of their effectiveness and mechanism in modulating bone homeostasis. CQ and HCQ inhibit osteoblastic activity by suppressing autophagy, inducing oxidative stress and promoting osteoblast apoptosis. CQ suppresses osteoclastic activity by blocking the receptor activator of nuclear factor kappa-Beta/receptor activator of nuclear factor kappa-Beta ligand interaction, autophagy and inflammation. HCQ inhibits osteoclastogenesis by increasing the expression levels of osteoprotegerin, inducing osteoclast apoptosis and reducing cytokines without affecting autophagy. With regard to the molecular machineries, CQ and HCQ inhibit bone formation and bone resorption. Variations in dose, frequency and duration of CQ and HCQ treatment result in heterogenous outcomes. Further research is necessary to clarify the net effects of CQ and HCQ on bone through studies specifically designed to explore their direct impact as the primary objective. The use of these medications is broadening particularly in patients with autoimmune diseases who are at risk of skeletal disorders. However, their safety profiles, adverse effects and contraindications must be carefully monitored when administered for long-term use and in combination.
C1 [Wong, Sok Kuan] Univ Kebangsaan Malaysia, Fac Med, Dept Pharmacol, Level 17,Preclin Bldg,Jalan Yaacob Latif, Kuala Lumpur 56000, Malaysia.
C3 Universiti Kebangsaan Malaysia
RP Wong, SK (corresponding author), Univ Kebangsaan Malaysia, Fac Med, Dept Pharmacol, Level 17,Preclin Bldg,Jalan Yaacob Latif, Kuala Lumpur 56000, Malaysia.
EM sokkuan@ukm.edu.my
RI Wong, Sok/I-1243-2016
FU Fundamental Grant
FX Not applicable.
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NR 94
TC 0
Z9 0
U1 0
U2 0
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1791-2997
EI 1791-3004
J9 MOL MED REP
JI Mol. Med. Rep.
PD JUN
PY 2025
VL 31
IS 6
AR 168
DI 10.3892/mmr.2025.13533
PG 20
WC Oncology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Research & Experimental Medicine
GA 1SF0F
UT WOS:001472404800001
PM 40243121
DA 2025-06-11
ER

PT J
AU Zhang, B
   Liu, DD
AF Zhang, Bao
   Liu, Deding
TI Integrated bioinformatic analysis of the molecular mechanisms between
   type 2 diabetes mellitus and osteoarthritis
SO MEDICINE
LA English
DT Article
DE advanced glycation end products; bioinformatics; inflammation;
   osteoarthritis; type 2 diabetes mellitus
ID INTERLEUKIN-17; EXPRESSION; CARTILAGE
AB Type 2 diabetes mellitus (T2DM) is a metabolic syndrome that has been identified as an independent risk factor for osteoarthritis (OA) and may even trigger and exacerbate the progression of OA. However, the relationship between T2DM and OA is complex and has not yet been fully clarified by current research. In this study, we analyzed the potential mechanism of action between T2DM and OA by bioinformatics. Transcriptome sequencing data of T2DM (GSE25724) and OA (GSE55235) were downloaded from the gene expression omnibus. Differential expression analysis was performed for different subgroups to obtain differentially expressed genes. The protein-protein interaction network was constructed using overlapping genes and screened for hub targets. Then the enrichment analysis was performed separately for overlapping and hub targets. The GeneMANIA is used to predict functionally similar genes of hub genes. Differential expression analyses revealed that 184 genes are involved in both diseases together. The Kyoto Encyclopedia of Genes and Genomes pathway enrichment results showed that the overlapping genes were mainly involved in the advanced glycation end products-receptor of advanced glycation end products signaling pathway, the NF-kappa B signaling pathway, the mitogen-activated protein kinases signaling pathway, and the interleukin-17 signaling pathway in diabetic complications. The functions of genes similar to the hub genes are focused on cell chemotaxis, positive regulation of cell migration, positive regulation of RNA polymerase II transcription, regulation of leukocyte migration, epithelial cell proliferation, and integrated stress response signaling. The transcription factor Jun and C-X-C motif chemokine 8 may play an important role in the inflammatory response caused by advanced glycation end products. This study improves our understanding of T2DM complicating OA and helps to stimulate more effective treatments.
C1 [Zhang, Bao; Liu, Deding] Zhengzhou Univ, Zhengzhou Cent Hosp, Dept Joint & Sports Injuries, 16 Tongbai North Rd, Zhengzhou 450001, Peoples R China.
C3 Zhengzhou University
RP Liu, DD (corresponding author), Zhengzhou Univ, Zhengzhou Cent Hosp, Dept Joint & Sports Injuries, 16 Tongbai North Rd, Zhengzhou 450001, Peoples R China.
EM 402530124@qq.com; 879446108@qq.com
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NR 24
TC 0
Z9 0
U1 1
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD AUG 30
PY 2024
VL 103
IS 35
AR e39469
DI 10.1097/MD.0000000000039469
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA E6Q1D
UT WOS:001304221900026
PM 39213224
OA gold
DA 2025-06-11
ER

PT J
AU Kumazaki, S
   Hikita, H
   Tahata, Y
   Sung, JH
   Fukumoto, K
   Myojin, Y
   Sakane, S
   Murai, K
   Sasaki, Y
   Shirai, K
   Saito, Y
   Kodama, T
   Kakita, N
   Takahashi, H
   Toyoda, H
   Suda, G
   Morii, E
   Kojima, T
   Ebihara, T
   Shimizu, K
   Sasaki, Y
   Tatsumi, T
   Takehara, T
AF Kumazaki, Shusuke
   Hikita, Hayato
   Tahata, Yuki
   Sung, Ji Hyun
   Fukumoto, Kenji
   Myojin, Yuta
   Sakane, Sadatsugu
   Murai, Kazuhiro
   Sasaki, Yoichi
   Shirai, Kumiko
   Saito, Yoshinobu
   Kodama, Takahiro
   Kakita, Naruyasu
   Takahashi, Hirokazu
   Toyoda, Hidenori
   Suda, Goki
   Morii, Eiichi
   Kojima, Takashi
   Ebihara, Takeshi
   Shimizu, Kentaro
   Sasaki, Yutaka
   Tatsumi, Tomohide
   Takehara, Tetsuo
TI Serum growth differentiation factor 15 is a novel biomarker with high
   predictive capability for liver cancer occurrence in patients with MASLD
   regardless of liver fibrosis
SO ALIMENTARY PHARMACOLOGY & THERAPEUTICS
LA English
DT Article
ID ALCOHOL-USE; DISEASES
AB Background and Aims: Although metabolic dysfunction-associated steatotic liver disease (MASLD) patients with a Fib-4 index >1.3 are recommended for fibrosis evaluation via elastography or biopsy, a more convenient method identifying high-risk populations requiring follow-up is needed. We explored the utility of serum levels of growth differentiation factor-15 (GDF15), a cell stress-responsive cytokine related to metabolic syndrome, for stratifying the risk of clinical events in MASLD patients. Methods: Serum GDF15 levels were measured in 518 biopsy-performed MASLD patients, 216 MASLD patients for validation, and 361 health checkup recipients with MASLD. Results: In the biopsy-MASLD cohort, multivariate analysis indicated that the serum GDF15 level was a risk factor for liver cancer, independent of the fibrosis stage or Fib-4 index. Using a GDF15 cutoff of 1.75 ng/mL based on the Youden index, high-GDF15 patients, regardless of fibrosis status, had a higher liver cancer incidence rate. While patients with a Fib-4 index <1.3 or low-GDF15 rarely developed liver cancer, high-GDF15 patients with a Fib-4 index >1.3 developed liver cancer and decompensated liver events at significantly higher rates and had poorer prognoses. In the validation cohort, high-GDF15 patients had significantly higher incidences of liver cancer and decompensated liver events and poorer prognoses than low-GDF15 patients, whether limited to high-Fib-4 patients. Among health checkup recipients with MASLD, 23.0% had a Fib-4 index >1.3, 2.7% had a Fib-4 index >1.3 and >1.75 ng/mL GDF15. Conclusions: Serum GDF15 is a biomarker for liver cancer with high predictive capability and is useful for identifying MASLD patients requiring regular surveillance.
C1 [Kumazaki, Shusuke; Hikita, Hayato; Tahata, Yuki; Sung, Ji Hyun; Fukumoto, Kenji; Myojin, Yuta; Sakane, Sadatsugu; Murai, Kazuhiro; Sasaki, Yoichi; Shirai, Kumiko; Saito, Yoshinobu; Kodama, Takahiro; Tatsumi, Tomohide; Takehara, Tetsuo] Osaka Univ, Grad Sch Med, Dept Gastroenterol & Hepatol, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan.
   [Kakita, Naruyasu] Kaizuka City Hosp, Dept Gastroenterol & Hepatol, Osaka, Japan.
   [Takahashi, Hirokazu] Saga Univ, Saga Univ Hosp, Fac Med, Liver Ctr, Saga, Japan.
   [Toyoda, Hidenori] Ogaki Municipal Hosp, Dept Gastroenterol & Hepatol, Ogaki, Japan.
   [Suda, Goki] Hokkaido Univ, Grad Sch Med, Dept Gastroenterol & Hepatol, Sapporo, Japan.
   [Morii, Eiichi] Osaka Univ, Grad Sch Med, Dept Pathol, Osaka, Japan.
   [Kojima, Takashi; Ebihara, Takeshi; Shimizu, Kentaro] Osaka Univ, Grad Sch Med, Dept Traumatol & Acute Crit Med, Osaka, Japan.
   [Sasaki, Yutaka] Osaka Cent Hosp, Dept Gastroenterol, Osaka, Japan.
C3 The University of Osaka; Saga University; Ogaki Municipal Hospital;
   Hokkaido University; The University of Osaka; The University of Osaka
RP Takehara, T (corresponding author), Osaka Univ, Grad Sch Med, Dept Gastroenterol & Hepatol, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan.
EM takehara@gh.med.osaka-u.ac.jp
RI kodama, takahiro/AEV-0845-2022; Murai, Kazuhiro/ADY-0970-2022; Saito,
   Yoshinobu/JZC-6301-2024; Ebihara, Takeshi/GYU-7579-2022
OI Murai, Kazuhiro/0000-0001-8634-2922; Saito,
   Yoshinobu/0000-0002-0624-0449
FU Japan Agency for Medical Research and Development
FX We would like to express our deepest gratitude to Dr. Riichiro Nezu, Dr.
   Takeyoshi Yumiba, and Dr. Akira Amemiya (Osaka Central Hospital) for
   supporting the collection of the clinical samples and data and Dr. Rina
   Okada (Department of Gastroenterology and Hepatology, Osaka University
   Graduate School of Medicine) for collecting the clinical data.
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NR 40
TC 2
Z9 2
U1 1
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0269-2813
EI 1365-2036
J9 ALIMENT PHARM THER
JI Aliment. Pharmacol. Ther.
PD AUG
PY 2024
VL 60
IS 3
BP 327
EP 339
DI 10.1111/apt.18063
EA JUN 2024
PG 13
WC Gastroenterology & Hepatology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Pharmacology & Pharmacy
GA YC7G7
UT WOS:001237649700001
PM 38828944
OA Green Published
DA 2025-06-11
ER

PT J
AU Jadhav, D
   Saraswat, N
   Vyawahare, N
   Shirode, D
AF Jadhav, Devika
   Saraswat, Nikita
   Vyawahare, Neeraj
   Shirode, Devendra
TI Targeting the molecular web of Alzheimer's disease: unveiling pathways
   for effective pharmacotherapy
SO EGYPTIAN JOURNAL OF NEUROLOGY PSYCHIATRY AND NEUROSURGERY
LA English
DT Review
DE Aducanumab; Alzheimer's disease; beta-Amyloid; Cholinesterase
   inhibitors; Dementia; Cognitive dysfunction; Early-onset Alzheimer's
   disease; Inflammation; Late-onset Alzheimer's disease;
   N-Methyl-D-aspartate; Neurodegeneration; Neurofibrillary tangles;
   Memory; Neurocognitive disorders; Senile plaques; Tau proteins
ID DEMENTIA; NEUROPATHOLOGY; TRIAL; BETA; AGE
AB Introduction Alzheimer's disease is a neurocognitive disorder that affects elderly people by slowly impaired cognition, dementia, and gets worse with age. It slowly impacts the quality of life. Clinically, it is distinguished by a transition from episodic memory to a gradual reduction in cognitive ability leading to cognitive dysfunction. Neurofibrillary tangles and amyloid plaques are unique structures that are thought to have a role in the pathogenesis of Alzheimer's disease. In this review, we focus our attention on the risk factors, pathophysiology, etiology, epidemiology, stages, diagnosis, treatment, mechanisms, pathways, ongoing clinical trials data and risks potentially associated with the development of Alzheimer's disease.Short summary This review aims to extrapolate the information about Alzheimer's disease. Preliminary research was done by selecting reviews on PubMed, Elsevier, and Google open-access publications using the keywords like "Alzheimer, dementia, neurodegenerative, memory, amyloid beta, mechanism of action, pathways".Conclusion Here we show the discussion and interpretation of several signaling pathways in the pathogenesis of Alzheimer's disease such as amyloid beta plaque cleavage, Metal ion hypothesis, amyloid beta degradation, initiation of amyloidogenic and non-amyloidogenic pathway, oxidative stress hypothesis, Metabolic syndrome, insulin resistance and tau phosphorylation associated apolipoprotein- cholesterol, neurofibrillary tangles accumulation, and insulin resistance which are significant for better understanding of the disease initiation and progression. On studying the ongoing clinical trials, it was found that current drugs being tested are crenezumab, gantenerumab and sodium oligonucleotide.
C1 [Jadhav, Devika; Saraswat, Nikita; Vyawahare, Neeraj; Shirode, Devendra] D D Y Patil Coll Pharm, Pharmacol Dept, DY Patil Educ Complex, Akurdi,Sect Pradhikaran,Nigdi, Pune 411044, Maharashtra, India.
RP Saraswat, N (corresponding author), D D Y Patil Coll Pharm, Pharmacol Dept, DY Patil Educ Complex, Akurdi,Sect Pradhikaran,Nigdi, Pune 411044, Maharashtra, India.
EM nikita.saraswat07@gmail.com
RI Shirode, Devendra/HZM-1438-2023; Saraswat, Dr. Nikita/ADA-3112-2022
OI Shirode, Devendra/0000-0002-9698-6470
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NR 152
TC 6
Z9 6
U1 4
U2 26
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1687-8329
J9 EGYPT J NEUROL PSYCH
JI Egypt. J. Neurol. Psychiatr. Neurosurg.
PD JAN 11
PY 2024
VL 60
IS 1
AR 7
DI 10.1186/s41983-023-00775-8
PG 24
WC Neurosciences
WE Emerging Sources Citation Index (ESCI)
SC Neurosciences & Neurology
GA EU8I4
UT WOS:001141534500002
OA gold
DA 2025-06-11
ER

PT J
AU Munjizun, A
   Gluck, C
   Walston, L
   High, K
   Hunter, R
   Pratt-Phillips, S
AF Munjizun, A.
   Gluck, C.
   Walston, L.
   High, K.
   Hunter, R.
   Pratt-Phillips, S.
TI Effect of weight carriage on work effort in horses
SO COMPARATIVE EXERCISE PHYSIOLOGY
LA English
DT Article
DE equine; workload; exercise
ID BODY CONDITION; FAT; OBESITY; LAMINITIS; RESPONSES
AB Excessive adiposity in horses is associated with equine metabolic syndrome and laminitis, and additional weight due to fat accumulation may cause further stress on the horse. This study aimed to determine the effect of additional weight carriage on work effort in horses, as estimated by changes in heart rate (HR) and body temperature (Temp). Eight mature mixed-breed horses were paired based on body size in a randomised crossover study. Each day tested a pair of horses with one horse carrying additional weight (15% of body weight; to represent approximately 3 body condition scores) and the other horse serving as a control, with treatments reversed the following week. Heart rate was determined before adding the weight, after a 2 h period of stall rest (prior to the exercise bout), and at the end of a 34 min exercise challenge of walking and trotting on an automated exerciser. Temp was recorded prior to exercise and after the horses were removed from the exerciser. Two-way ANOVA was conducted to determine the effect of exercise and weight carriage on HR and Temp, and paired t-tests were used to compare differences in HR and Temp pre- and post-exercise. HR increased with exercise (P < 0.001) and was higher following exercise in horses carrying additional weight (P < 0.0001). Exercise increased Temp (P < 0.001) and the difference in Temp was greater in the weight-carrying group (P = 0.0023). This study documents the effect of weight carriage that could be imposed with body fat, in addition to the known health detriments of adiposity.
C1 [Munjizun, A.; Gluck, C.; High, K.; Hunter, R.; Pratt-Phillips, S.] North Carolina State Univ, Dept Anim Sci, 120 Broughton Dr, Raleigh, NC 27607 USA.
   [Walston, L.] Martin Community Coll, 1161 Kehukee Pk Rd, Williamston, NC 27892 USA.
C3 North Carolina State University
RP Pratt-Phillips, S (corresponding author), North Carolina State Univ, Dept Anim Sci, 120 Broughton Dr, Raleigh, NC 27607 USA.
EM amunjiz@ncsu.edu
OI Gluck-Flynn, Cassandra/0000-0002-7391-6189; Pratt-Phillips,
   Shannon/0000-0003-4130-6957
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NR 36
TC 1
Z9 1
U1 0
U2 1
PU WAGENINGEN ACADEMIC PUBLISHERS
PI WAGENINGEN
PA PO BOX 220, WAGENINGEN, 6700 AE, NETHERLANDS
SN 1755-2540
EI 1755-2559
J9 COMP EXERC PHYSIOL
JI Comp. Exerc. Physiol.
PD DEC
PY 2023
VL 19
IS 5
BP 511
EP 516
DI 10.1163/17552559-20220066
PG 6
WC Veterinary Sciences
WE Emerging Sources Citation Index (ESCI)
SC Veterinary Sciences
GA GN6I4
UT WOS:001153383600012
DA 2025-06-11
ER

PT J
AU Wang, XL
   Yang, YF
   Zhao, D
   Zhang, S
   Chen, Y
   Chen, YL
   Feng, K
   Li, XJ
   Han, JH
   Iwakiri, Y
   Duan, YJ
   Yang, XX
AF Wang, Xiaolin
   Yang, Yanfang
   Zhao, Dan
   Zhang, Shuang
   Chen, Yi
   Chen, Yuanli
   Feng, Ke
   Li, Xiaoju
   Han, Jihong
   Iwakiri, Yasuko
   Duan, Yajun
   Yang, Xiaoxiao
TI Inhibition of high-fat diet-induced obesity via reduction of
   ER-resident protein Nogo occurs through multiple mechanisms
SO JOURNAL OF BIOLOGICAL CHEMISTRY
LA English
DT Article
ID NF-KAPPA-B; BROWN ADIPOSE-TISSUE; SKELETAL-MUSCLE; METABOLIC SYNDROME;
   INFLAMMATION; STRESS; RECEPTOR; MICE; MACROPHAGES; SUPPRESSION
AB Obesity is a risk factor for insulin resistance, type 2 diabetes, and cardiovascular diseases. Reticulon-4 (Nogo) is an endo-plasmic reticulum-resident protein with unclear functions in obesity. Herein, we investigated the effect of Nogo on obesity and associated metabolic disorders. Human serum samples were collected to explore the relationship between circulating Nogo-B and body mass index value. Nogo-deficient and WT littermate control mice were fed normal chow or high-fat diet (HFD) for 14 weeks, and HFD-induced obese C57BL/6J mice were injected scrambled or Nogo siRNA for 2 weeks. We found that in human and mouse serum, Nogo-B was positively correlated to body mass index/bodyweight and lipid profiles. Reduced Nogo (by genetic deletion or siRNA transfection) protected mice against HFD-induced obesity and related metabolic disorders. We demonstrate that Nogo deficiency reversed HFD-induced whitening of brown adipose tissue, thereby increasing thermogenesis. It also ameliorated lipid accumulation in tissues by activating the adiponectin- adiponectin receptor 1-AMP-activated kinase alpha signaling axis. Finally, Nogo deficiency potently reduced HFD-induced serum proinflammatory cytokines and infiltration of macro-phages into metabolic organs, which is related to enhanced NF-kappa B p65 degradation via the lysosome pathway. Collectively, our study suggests that reduced levels of Nogo protect mice against HFD-induced obesity by increasing thermogenesis and energy metabolism while inhibiting NF-kappa B-mediated inflam-mation. Our results indicate that inhibition of Nogo may be a potential strategy for obesity treatment.
C1 [Wang, Xiaolin; Yang, Yanfang; Zhao, Dan; Chen, Yi; Feng, Ke; Li, Xiaoju; Han, Jihong] Nankai Univ, Coll Life Sci, State Key Lab Med Chem Biol, Key Lab Bioact Mat,Minist Educ, Tianjin, Peoples R China.
   [Zhang, Shuang; Chen, Yuanli; Han, Jihong; Duan, Yajun; Yang, Xiaoxiao] Hefei Univ Technol, Coll Food & Biol Engn, Key Lab Metab & Regulat Major Dis Anhui Higher Ed, Hefei, Peoples R China.
   [Iwakiri, Yasuko] Yale Univ, Sect Digest Dis, Sch Med, New Haven, CT USA.
C3 Ministry of Education - China; Nankai University; Hefei University of
   Technology; Yale University
RP Duan, YJ; Yang, XX (corresponding author), Hefei Univ Technol, Coll Food & Biol Engn, Key Lab Metab & Regulat Major Dis Anhui Higher Ed, Hefei, Peoples R China.
EM yduan@hfut.edu.cn; jangxiaoxiao@hfut.edu.cn
RI Duan, Yajun/LJK-9029-2024; Chen, Yuanli/HLW-9619-2023; zhao,
   dan/MGT-6882-2025
OI Yang, Xiaoxiao/0000-0003-0290-2844
FU National Natural Science Foundation of China [81973316, 82173807]; China
   Postdoctoral Science Foundation [2020M681914]; Tianjin Municipal Science
   and Technology Commission of China [20JCZDJC00710]; Fundamental Research
   Funds for the Central Universities (Nankai University) [63211045]
FX This work was supported by the National Natural Science Foundation of
   China grants 81973316 (to J. H.) and 82173807 (to Y. D.); the China
   Postdoctoral Science Foundation grant 2020M681914 (to X. Y.); and
   Tianjin Municipal Science and Technology Commission of China grant
   20JCZDJC00710 and the Fundamental Research Funds for the Central
   Universities (Nankai University) (grant no.: 63211045 to J. H.).
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Z9 13
U1 3
U2 16
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
EI 1083-351X
J9 J BIOL CHEM
JI J. Biol. Chem.
PD FEB
PY 2022
VL 298
IS 2
AR 101561
DI 10.1016/j.jbc.2022.101561
EA FEB 2022
PG 18
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA ZI1NP
UT WOS:000761395300003
PM 34998825
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Garcia, GM
   Roy, JM
   Pitta, IR
   Abdalla, DSP
   Grabe-Guimaraes, A
   Mosqueira, VCF
   Richard, S
AF Garcia, Giani M.
   Roy, Jerome
   Pitta, Ivan R.
   Abdalla, Dulcineia S. P.
   Grabe-Guimaraes, Andrea
   Mosqueira, Vanessa C. F.
   Richard, Sylvain
TI Polylactide Nanocapsules Attenuate Adverse Cardiac Cellular Effects of
   Lyso-7, a Pan-PPAR Agonist/Anti-Inflammatory New Thiazolidinedione
SO PHARMACEUTICS
LA English
DT Article
DE peroxisome proliferator-activated receptor-gamma; cardiotoxicity;
   metabolic syndrome; atherosclerosis; contraction; calcium transient;
   ectopic diastolic Ca2+ events; polymeric nanoparticle
ID TYPE-2 DIABETES-MELLITUS; MYOCARDIAL-INFARCTION; NATRIURETIC PEPTIDE;
   CA2+ SENSITIVITY; HEART-FAILURE; CALCIUM; RISK; ROSIGLITAZONE;
   PIOGLITAZONE; EXCHANGE
AB Lyso-7 is a novel synthetic thiazolidinedione, which is a receptor (pan) agonist of PPAR alpha,beta/delta,gamma with anti-inflammatory activity. We investigated the cardiotoxicity of free Lyso-7 in vitro (4.5-450 nM), and Lyso-7 loaded in polylactic acid nanocapsules (NC) in vivo (Lyso-7-NC, 1.6 mg/kg). In previous work, we characterized Lyso-7-NC. We administered intravenously Lyso-7, Lyso-7-NC, control, and blank-NC once a day for seven days in mice. We assessed cell contraction and intracellular Ca2+ transients on single mice cardiomyocytes enzymatically isolated. Lyso-7 reduced cell contraction and accelerated relaxation while lowering diastolic Ca2+ and reducing Ca2+ transient amplitude. Lyso-7 also promoted abnormal ectopic diastolic Ca2+ events, which isoproterenol dramatically enhanced. Incorporation of Lyso-7 in NC attenuated drug effects on cell contraction and prevented its impact on relaxation, diastolic Ca2+, Ca2+ transient amplitude, Ca2+ transient decay kinetics, and promotion of diastolic Ca2+ events. Acute effects of Lyso-7 on cardiomyocytes in vitro at high concentrations (450 nM) were globally similar to those observed after repeated administration in vivo. In conclusion, we show evidence for off-target effects of Lyso-7, seen during acute exposure of cardiomyocytes to high concentrations and after repeated treatment in mice. Nano-encapsulation of Lyso-7 in polymeric NC attenuated the unwanted effects, particularly ectopic Ca2+ events known to support life-threatening arrhythmias favored by stress or exercise.
C1 [Garcia, Giani M.; Roy, Jerome; Richard, Sylvain] Univ Montpellier, CNRS UMR 9214, Inserm U1046, PhyMedExp, F-34270 Montpellier, France.
   [Garcia, Giani M.; Grabe-Guimaraes, Andrea; Mosqueira, Vanessa C. F.] Univ Fed Ouro Preto, Sch Pharm, Dept Pharm, BR-35400000 Ouro Preto, Brazil.
   [Pitta, Ivan R.] Univ Fed Pernambuco, Ctr Hlth Sci, BR-50670420 Recife, PE, Brazil.
   [Abdalla, Dulcineia S. P.] Univ Sao Paulo, Fac Pharmaceut Sci, Dept Clin & Toxicol Anal, BR-05508000 Sao Paulo, Brazil.
C3 Universite de Montpellier; Centre National de la Recherche Scientifique
   (CNRS); CNRS - National Institute for Biology (INSB); Institut National
   de la Sante et de la Recherche Medicale (Inserm); Universidade Federal
   de Ouro Preto; Universidade Federal de Pernambuco; Universidade de Sao
   Paulo
RP Richard, S (corresponding author), Univ Montpellier, CNRS UMR 9214, Inserm U1046, PhyMedExp, F-34270 Montpellier, France.
EM gianimg@gmail.com; jerome.roy@inra.fr; irpitta@gmail.com;
   dspabdalla@gmail.com; grabe@ufop.edu.br; mosqueira@ufop.edu.br;
   sylvain.richard@inserm.fr
RI Roy, Jerome/AAX-9842-2021; Grabe-Guimarães, Andrea/AAY-5454-2020;
   Richard, Sylvain/C-9695-2016; Mosqueira, Vanessa/G-2670-2010
OI jerome, roy/0000-0002-3007-1585; Mosqueira, Vanessa/0000-0002-0368-6090;
   Richard, Sylvain/0000-0001-9460-6705; Grabe-Guimaraes,
   Andrea/0000-0002-6503-5314
FU CAPES/COFECUB between Brazil and France [768-13]; NANOBIOMG-Network
   (FAPEMIG, Minas Gerais, Brazil) [00007-14, APQ-02864-16]; CAPES/Embrapa
   [133-Ed.15/2014]; CAPES/DS-Brazil scholarship
FX A bilateral research collaborative grant from CAPES/COFECUB between
   Brazil and France (#768-13; V.C.F.M., A.G.-G., and S.R),
   NANOBIOMG-Network (#00007-14, APQ-02864-16); FAPEMIG, Minas Gerais,
   Brazil) supported this work. G.M.G. received a CAPES/DS-Brazil
   scholarship and CAPES/Embrapa 133-Ed.15/2014 postdoctoral fellowship. IR
   Pitta, D.S.P. Abdalla, and V.C.F. Mosqueira are research fellows of
   CNPq, Brazil.
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NR 34
TC 6
Z9 6
U1 0
U2 6
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1999-4923
J9 PHARMACEUTICS
JI Pharmaceutics
PD SEP
PY 2021
VL 13
IS 9
AR 1521
DI 10.3390/pharmaceutics13091521
PG 13
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA UV9ZD
UT WOS:000699826700001
PM 34575597
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Zhang, H
   Qi, RL
   Zeng, YH
   Tsao, R
   Mine, Y
AF Zhang, Hua
   Qi, Ruili
   Zeng, Yuhan
   Tsao, Rong
   Mine, Yoshinori
TI Chinese Sweet Leaf Tea (Rubus suavissimus) Mitigates LPS-Induced
   Low-Grade Chronic Inflammation and Reduces the Risk of Metabolic
   Disorders in a C57BL/6J Mouse Model
SO JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
LA English
DT Article
DE sweet leaf tea; gut inflammation; lipopolysaccharides metabolic
   disorder; gut permeability
ID HIGH-FAT DIET; MUCOSAL BARRIER FUNCTION; NF-KAPPA-B; ADIPOSE-TISSUE;
   GALLIC ACID; INTESTINAL PERMEABILITY; INSULIN-RESISTANCE; OXIDATIVE
   STRESS; GENE-EXPRESSION; GUT MICROBIOTA
AB Chronic exposure to minute doses of endotoxin elicits intestinal inflammation and impairs the gut barrier function, potentially resulting in systemic inflammation with elevated concentrations of biomarkers associated with metabolic syndrome. This study aimed to investigate the preventive effects of the Rubus suavissimus S. Lee leaf extract in a model of low-grade systemic inflammation. The predominant compounds found in the leaf extract are gallic acids, ellagic acid, and rubusoside. Results of the present study showed that IL suavissimus leaf extract supplementation could help preserve intestinal barrier integrity by upregulating the expression of the tight junction proteins [e.g., zonula occluden-1 (ZO-1) and junctional adhesion molecule-1 (JAMA)] and mucin (MUC)-4 and also suppress the release of plasmatic proinflammatory cytokines, including tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, and monocyte chemotactic protein (MCP)-1, while restoring the production of anti-inflammatory adiponectin. We subsequently determined that the leaf extract contributes to restoring glucose metabolic homeostasis through maintaining insulin sensitivity. Furthermore, our mechanistic finding demonstrated that the R. suavissimus leaf extract supplementation prevented systemic inflammation-driven impaired insulin sensitivity in white adipose tissues (WATs) by modulating the expression of peroxisome-proliferator-activated receptor-gamma (PPAR-gamma) and insulin receptor subset-1 (IRS-1). Altogether, our findings suggest that the above supplementation contributes to restoring immune and metabolic homeostasis to enhance the overall health of the host thereby preventing the early onset of metabolic disorders such as obesity and type 2 diabetes.
C1 [Zhang, Hua; Qi, Ruili; Zeng, Yuhan; Mine, Yoshinori] Univ Guelph, Dept Food Sci, Guelph, ON N1G 2W1, Canada.
   [Zhang, Hua; Tsao, Rong] Agr & Agri Food Canada, Guelph Food Res & Dev Ctr, 93 Stone Rd West, Guelph, ON N1G 5C9, Canada.
C3 University of Guelph; Agriculture & Agri Food Canada
RP Mine, Y (corresponding author), Univ Guelph, Dept Food Sci, Guelph, ON N1G 2W1, Canada.
EM ymine@uoguelph.ca
RI Zhang, hua/AAF-9354-2019; ZENG, Yuhan/KWU-3357-2024; Tsao,
   Rong/I-3096-2014
OI Tsao, Rong/0000-0001-6537-1820
FU University of Guelph-OMAFRA partnership program [Health-030079]
FX This work was supported by the University of Guelph-OMAFRA partnership
   program (Food for Health-030079).
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NR 52
TC 27
Z9 33
U1 1
U2 73
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0021-8561
EI 1520-5118
J9 J AGR FOOD CHEM
JI J. Agric. Food Chem.
PD JAN 8
PY 2020
VL 68
IS 1
BP 138
EP 146
DI 10.1021/acs.jafc.9b05975
PG 9
WC Agriculture, Multidisciplinary; Chemistry, Applied; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture; Chemistry; Food Science & Technology
GA KC4JV
UT WOS:000507147100014
PM 31873011
DA 2025-06-11
ER

PT J
AU Mao, ZJ
   Lin, M
   Zhang, X
   Qin, LP
AF Mao, Zhu-Jun
   Lin, Min
   Zhang, Xin
   Qin, Lu-Ping
TI Combined Use of Astragalus Polysaccharide and Berberine Attenuates
   Insulin Resistance in IR-HepG2 Cells via Regulation of the
   Gluconeogenesis Signaling Pathway
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Article
DE astragalus polysaccharide; berberine; insulin resistance; IR-HepG2 cell
   model; intracellular calcium flux; gluconeogenesis signaling pathway
ID HEPATIC GLUCOSE-PRODUCTION; TRANSCRIPTION FACTORS; INTRACELLULAR CA2+;
   LIVER; MITOCHONDRIA; STRESS; HOMEOSTASIS; ACTIVATION; MECHANISM; INJURY
AB Insulin resistance (IR) is likely to induce metabolic syndrome and type 2 diabetes mellitus (T2DM). Gluconeogenesis (GNG) is a complex metabolic process that may result in glucose generation from certain non-carbohydrate substrates. Chinese herbal medicine astragalus polysaccharides and berberine have been documented to ameliorate IR, and combined use of astragalus polysaccharide (AP) and berberine (BBR) are reported to synergistically produce an even better effect. However, what change may occur in the GNG signaling pathway of IR-HepG2 cells in this synergistic effect and whether AP-BBR attenuates IR by regulating the GNG signaling pathway remain unclear. For the first time, we discovered in this study that the optimal time of IR-HepG2 cell model formation was 48 h after insulin intervention. AP-BBR attenuated IR in HepG2 cells and the optimal concentration was 10 mg. AP-BBR reduced the intracellular H2O2 content with no significant effect on apoptosis of IR-HepG2 cells. In addition, a rapid change was observed in intracellular calcium current of the IR-HepG2 cell model, and AP-BBR intervention attenuated this change markedly. The gene sequencing results showed that the GNG signaling pathway was one of the signaling pathways of AP-BBR to attenuate IR in IR-Hepg2 cells. The expression of p-FoxO1(Ser256) and PEPCK protein was increased, and the expression of GLUT2 protein was decreased significantly in the IR-HepG2 cell model, and both of these effects could be reversed by AP-BBR intervention. AP-BBR attenuated IR in IR-HepG2 cells, probably by regulating the GNG signaling Pathway.
C1 [Mao, Zhu-Jun; Zhang, Xin; Qin, Lu-Ping] Zhejiang Chinese Med Univ, Coll Pharmaceut Sci, Hangzhou, Peoples R China.
   [Lin, Min] Zhejiang Chinese Med Univ, Coll Basic Med Sci, Hangzhou, Peoples R China.
C3 Zhejiang Chinese Medical University; Zhejiang Chinese Medical University
RP Mao, ZJ; Qin, LP (corresponding author), Zhejiang Chinese Med Univ, Coll Pharmaceut Sci, Hangzhou, Peoples R China.
EM maozhujun0107@163.com; qinsmmu@126.com
RI min, lin/AAJ-7325-2020
FU National Natural Science Foundation of China [81603351]
FX This study was supported by a grant from the National Natural Science
   Foundation of China (No. 81603351).
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NR 45
TC 35
Z9 40
U1 5
U2 98
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD DEC 23
PY 2019
VL 10
AR 1508
DI 10.3389/fphar.2019.01508
PG 11
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA KA4NB
UT WOS:000505772500001
PM 31920677
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Darby, JRT
   Dollah, MHBM
   Regnault, TRH
   Williams, MT
   Morrison, JL
AF Darby, Jack R. T.
   Dollah, Murni H. B. Mohd
   Regnault, Timothy R. H.
   Williams, Marie T.
   Morrison, Janna L.
TI Systematic review: Impact of resveratrol exposure during pregnancy on
   maternal and fetal outcomes in animal models of human pregnancy
   complications-Are we ready for the clinic?
SO PHARMACOLOGICAL RESEARCH
LA English
DT Review
DE Resveratrol; Pregnancy; DOHaD; Fetus
ID INTRAUTERINE GROWTH RESTRICTION; HIGH-FAT DIET; INDUCED COGNITIVE
   IMPAIRMENT; OXIDATIVE STRESS; IN-UTERO; CARDIOVASCULAR HEALTH; VASCULAR
   DYSFUNCTION; CALORIE RESTRICTION; METABOLIC SYNDROME; PRENATAL HYPOXIA
AB Resveratrol (RSV) has been reported to have potential beneficial effects in the complicated pregnancy. Various pregnancy complications lead to a suboptimal in utero environment that impacts fetal growth during critical windows of development. Detrimental structural changes to key organ systems in utero persist into adult life and predispose offspring to an increased risk of chronic non-communicable metabolic diseases such as cardiovascular disease, diabetes and obesity. The aim of this systematic review was to determine the effect of gestational RSV exposure on both maternal and fetal outcomes. Publicly available databases (n = 8) were searched for original studies reporting maternal and/or fetal outcomes after RSV exposure during pregnancy irrespective of species. Of the 115 studies screened, 31 studies were included in this review. RSV exposure occurred for different durations across a range of species (Rats n = 18, Mice n = 7, Japanese Macaques n = 3 and Sheep n = 3), models of complicated pregnancy (eg. maternal dietary manipulations, gestational diabetes, maternal hypoxia, teratogen exposure, etc.), dosages and administration routes. Maternal and fetal outcomes differed not only based on the model of complicated pregnancy assessed but also as a result of species. Given the heterogenic nature of these studies, further investigation assessing RSV exposure during the complicated pregnancy is warranted. In order to make an informed decision regarding the use of RSV to intervene in pregnancy complications, we suggest a minimum data set for consideration in future studies.
C1 [Darby, Jack R. T.; Dollah, Murni H. B. Mohd; Morrison, Janna L.] Univ South Australia, Sch Pharm & Med Sci, Early Origins Adult Hlth Res Grp, GPO Box 2471, Adelaide, SA 5001, Australia.
   [Regnault, Timothy R. H.] Western Univ, Dept Obstet & Gynaecol, 1151 Richmond St, London, ON N6A 5C1, Canada.
   [Regnault, Timothy R. H.] Western Univ, Dept Physiol & Pharmacol, 1151 Richmond St, London, ON N6A 5C1, Canada.
   [Regnault, Timothy R. H.] Childrens Hlth Res Inst, 800 Commissioners Rd East, London, ON N6C 2V5, Canada.
   [Williams, Marie T.] Univ South Australia, Sch Hlth Sci, Hlth & Alliance Res Exercise Nutr & Act ARENA, Adelaide, SA, Australia.
C3 University of South Australia; Western University (University of Western
   Ontario); Western University (University of Western Ontario); University
   of South Australia
RP Morrison, JL (corresponding author), Univ South Australia, Sch Pharm & Med Sci, Early Origins Adult Hlth Res Grp, GPO Box 2471, Adelaide, SA 5001, Australia.
EM Janna.Morrison@unisa.edu.au
RI Regnault, Timothy/J-8902-2014; Darby, Jack/JVN-4755-2024; Williams,
   Marie/C-8152-2009; Morrison, Janna/B-8308-2009
OI Darby, Jack/0000-0001-7114-3920; Williams, Marie/0000-0002-0473-5157;
   Regnault, Timothy/0000-0003-1930-8358; Morrison,
   Janna/0000-0002-8602-8519
FU NHMRC [APP1066916]; Australian Research Council [FT170100431];
   Australian Government; Australian Research Council [FT170100431] Funding
   Source: Australian Research Council
FX JLM was funded by a NHMRC Career Development Fellowship (APP1066916) and
   an Australian Research Council Future Fellowship (Level 3; FT170100431).
   JRTD was funded by an Australian Government Research Training Program
   (RTP) scholarship.
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NR 107
TC 33
Z9 35
U1 0
U2 7
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 1043-6618
J9 PHARMACOL RES
JI Pharmacol. Res.
PD JUN
PY 2019
VL 144
BP 264
EP 278
DI 10.1016/j.phrs.2019.04.020
PG 15
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA IH2MK
UT WOS:000474328700023
PM 31029765
DA 2025-06-11
ER

PT J
AU Mahboobi, S
   Jafarnejad, S
   Eftekhari, MH
AF Mahboobi, Sepideh
   Jafarnejad, Sadegh
   Eftekhari, Mohammad Hassan
TI Royal jelly does not improve markers of glycemia: A systematic review
   and meta-analysis of Randomized Clinical Trials
SO COMPLEMENTARY THERAPIES IN MEDICINE
LA English
DT Review
DE Royal jelly; Glycemia; Systematic review; Meta-analysis
ID INSULIN-RESISTANCE; METABOLIC SYNDROME; FUNCTIONAL FOODS; OXIDATIVE
   STRESS; SUPPLEMENTATION; MANAGEMENT; GLUCOSE; OBESITY; MODEL; DIET
AB Bee products including propolis, bee wax, pollen and royal jelly (RJ) have been used as medicine from ancient times. A vast number of in-vivo and in-vitro studies as well as clinical trials have been conducted to investigate potential health related properties of RJ. A growing number of clinical trials have been performed to assess effects of LI ingestion on different metabolic markers including glycemia, with diverse results. In the current meataanalysis, we aimed to evaluate effects of RJ ingestion on glycemic markers compared with placebo and set directions for future research. Electronic databases including Scopus, Pubmed, Scholar, Cochrane, Proquest, SID and Magiran were searched and 5 eligible studies were included in the quantitative analysis. Review Manager Software was used for statistical analysis and random effects model was used for pooling data. A total of 205 participants for FPG and 130 participants for HbA1c were included. The overall analysis revealed that RJ consumption reduced FPG by 0.95 mg/dl (95% CI: - 5.83 to 3.87; p = 0.69; 12 = 0%; Tau(2) = 0.00) and HbA1c by 0.32 (95% CI: -0.87 to 0.23; p = 0.25; 12 = 69 %; Tau(2) = 0.16) which were not statistically significant. Funnel plot demonstrated no publication bias. In conclusion, RJ supplementation did not beneficially affect markers of glycemia. However, due to methodology issues and potential confounders like diet as well as diverse populations, we recommend future studies well designed and well controlled for major confounders so we can update these data to more precise results and more accurate conclusion.
C1 [Mahboobi, Sepideh] Shiraz Univ Med Sci, Student Res Comm, Shiraz, Iran.
   [Jafarnejad, Sadegh] Kashan Univ Med Sci, Res Ctr Biochem & Nutr Metab Dis, Kashan, Iran.
   [Eftekhari, Mohammad Hassan] Shiraz Univ Med Sci, Sch Nutr & Food Sci, Dept Clin Nutr, Shiraz, Iran.
C3 Shiraz University of Medical Science; Shiraz University of Medical
   Science
RP Eftekhari, MH (corresponding author), Sch Nutr & Food Sci, Razi Ave,POB 7153675541, Shiraz, Iran.
EM h_eftekhari@yahoo.com
RI Mahboobi, Sepideh/AAJ-2136-2020
OI Jafarnejad, Sadegh/0000-0002-4666-1918
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NR 48
TC 4
Z9 5
U1 0
U2 10
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0965-2299
EI 1873-6963
J9 COMPLEMENT THER MED
JI Complement. Ther. Med.
PD JUN
PY 2019
VL 44
BP 235
EP 241
DI 10.1016/j.ctim.2019.04.017
PG 7
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA IC6LB
UT WOS:000471082500033
PM 31126561
DA 2025-06-11
ER

PT J
AU Lönnberg, L
   Ekblom-Bak, E
   Damberg, M
AF Lonnberg, Lena
   Ekblom-Bak, Elin
   Damberg, Mattias
TI Improved unhealthy lifestyle habits in patients with high cardiovascular
   risk: results from a structured lifestyle programme in primary care
SO UPSALA JOURNAL OF MEDICAL SCIENCES
LA English
DT Article
DE Cardiovascular prevention; general practice; hypertension; lifestyle
   habits; structured lifestyle programme; type 2 diabetes mellitus
ID DISEASE PREVENTION; PHYSICAL-ACTIVITY; DIETARY PATTERNS; INTERVENTION;
   HYPERTENSION; GUIDELINES; EVENTS; PEOPLE; ADULTS
AB Background. Physical activity, healthful dietary habits, and not smoking are associated with reduced cardiovascular morbidity and mortality. However, few studies have examined how counselling to improve poor lifestyle habits might be carried out in clinical practice. In Swedish primary care, structured lifestyle counselling is still not integrated into everyday clinical practice. The aim of the present study was two-fold: (1) to describe a novel lifestyle intervention programme in primary care; and (2) to evaluate change in unhealthy lifestyle habits over 1 year in men and women with high cardiovascular risk who participated in the lifestyle intervention programme. Method. A single-group study with a 1-year follow-up was carried out. A total of 417 people was enrolled, median age 62 years (54% women), with either hypertension (69%), type 2 diabetes mellitus, or impaired glucose tolerance. The 1-year intervention included five counselling sessions that focused on lifestyle habits, delivered by a district nurse with postgraduate credits in diabetes care and the metabolic syndrome. All patients were offered in-depth counselling for one or more lifestyle habits when needed. Lifestyle habits were assessed by a questionnaire at baseline and 1-year follow-up. Total change was assessed using a nine-factor unhealthy lifestyle habit index. Results. Favourable, significant changes were observed for physical activity, dietary habits, smoking, and stress over 1 year. Similar improvements were seen for both sexes and type of diagnosis. Conclusions. The results support the utility of a multifactorial, structured approach to change unhealthy lifestyle habits for cardiovascular risk prevention in a primary care setting.
C1 [Lonnberg, Lena; Damberg, Mattias] Uppsala Univ, Ctr Clin Res, Vasteras, County Of Vastm, Sweden.
   [Lonnberg, Lena; Damberg, Mattias] Uppsala Univ, Dept Publ Hlth & Caring Sci, Family Med & Prevent Med, Uppsala, Sweden.
   [Ekblom-Bak, Elin] Swedish Sch Sports & Hlth Sci, Stockholm, Sweden.
C3 Uppsala University; Uppsala University; Swedish School of Sport & Health
   Sciences
RP Lönnberg, L (corresponding author), Vasteras Hosp, Ctr Klin Forskning, S-72189 Vasteras, Sweden.
EM lena.lonnberg@regionvastmanland.se
RI Ekblom-Bak, Elin/AFR-0681-2022; Damberg, Mattias/HKM-9119-2023
OI Ekblom-Bak, Elin/0000-0002-3901-7833; Lonnberg,
   Lena/0000-0003-4706-6915; Damberg, Mattias/0000-0001-7654-7553
FU Praktikertjanst AB, Stockholm, Sweden
FX Funding was received from Praktikertjanst AB, 103 55 Stockholm, Sweden.
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NR 36
TC 13
Z9 13
U1 0
U2 10
PU UPSALA MED SOC
PI UPPSALA
PA BOX 571, UPPSALA, SWEDEN
SN 0300-9734
EI 2000-1967
J9 UPSALA J MED SCI
JI Ups. J. Med. Sci.
PD APR 3
PY 2019
VL 124
IS 2
BP 94
EP 104
DI 10.1080/03009734.2019.1602088
EA MAY 2019
PG 11
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA IO2KL
UT WOS:000470479000001
PM 31063003
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Carey, AN
   Gildawie, KR
   Rovnak, A
   Thangthaeng, N
   Fisher, DR
   Shukitt-Hale, B
AF Carey, Amanda N.
   Gildawie, Kelsea R.
   Rovnak, Abigail
   Thangthaeng, Nopporn
   Fisher, Derek R.
   Shukitt-Hale, Barbara
TI Blueberry supplementation attenuates microglia activation and increases
   neuroplasticity in mice consuming a high-fat diet
SO NUTRITIONAL NEUROSCIENCE
LA English
DT Article
DE BDNF; Berry; Blueberry; High-fat diet; Hippocampus; Microglia;
   Neurogenesis; Neuroplasticity
ID NEUROTROPHIC FACTOR; OXIDATIVE STRESS; FRUIT POLYPHENOLICS;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; SPATIAL MEMORY; BRAIN;
   INFLAMMATION; BEHAVIOR; MECHANISMS
AB Objectives: Consuming a high-fat diet (HFD) may result in behavioral deficits similar to those observed in aging animals. Blueberries may prevent and even reverse age-related alterations in neurochemistry and behavior. It was previously demonstrated that middle-aged mice fed HFD had impaired memory; however, supplementation of HFD with blueberry reduced these memory deficits. As a follow-up to that study, the brain tissue from HFD-fed mice with and without blueberry supplementation was assessed to determine the neuroprotective mechanism(s) by which blueberry allayed cognitive dysfunction associated with HFD. Methods: Mice were fed HFDs (60% calories from fat) or low-fat diets (LFD) with and without 4% blueberry (freeze-dried, U.S. Highbush Blueberry Council). Microglia activation was assessed ex vivo and in vitro. The hippocampus was assessed for brain-derived neurotrophic factor (BDNF) and neurogenesis by measuring doublecortin (DCX). Results: There was significantly less microglia ionized calcium binding adaptor molecule 1 staining and fewer microglia in the brains of mice fed HFD + blueberry compared to mice fed LFD and HFD. BV-2 microglial cells treated with serum collected from the mice fed the diets supplemented with blueberry produced less nitric oxide compared to cells treated with serum from mice fed HFD. BDNF levels were higher and the number of DCX-positive cells was greater in the hippocampus of mice fed HFD + blueberry compared to mice fed HFD. Discussion: This study demonstrated that supplementation of a HFD with blueberry reduced indices of microglia activation and increased neuroplasticity, and these changes may underlie the protection against memory deficits in HFD-fed mice supplemented with blueberry.
C1 [Carey, Amanda N.; Gildawie, Kelsea R.; Rovnak, Abigail] Simmons Coll, Dept Psychol, 300 Fenway, Boston, MA 02115 USA.
   [Thangthaeng, Nopporn; Fisher, Derek R.; Shukitt-Hale, Barbara] USDA, Human Nutr Res Ctr Aging, Neurosci & Aging Lab, Boston, MA USA.
C3 Simmons University; United States Department of Agriculture (USDA)
RP Carey, AN (corresponding author), Simmons Coll, Dept Psychol, 300 Fenway, Boston, MA 02115 USA.
EM amanda.carey@simmons.edu
RI Gildawie, Kelsea/ABA-4062-2021
OI Shukitt-Hale, Barbara/0000-0002-3810-1910
FU USDA Intramural funds; U.S. Highbush Blueberry Council
FX This work was supported by USDA Intramural funds; U.S. Highbush
   Blueberry Council.
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NR 64
TC 29
Z9 31
U1 2
U2 45
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1028-415X
EI 1476-8305
J9 NUTR NEUROSCI
JI Nutr. Neurosci.
PD APR 3
PY 2019
VL 22
IS 4
BP 253
EP 263
DI 10.1080/1028415X.2017.1376472
PG 11
WC Neurosciences; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Nutrition & Dietetics
GA HM6JU
UT WOS:000459581100004
PM 28931353
DA 2025-06-11
ER

PT J
AU Hsu, PS
   Lin, CM
   Chang, JF
   Wu, CS
   Sia, KC
   Lee, IT
   Huang, KY
   Lin, WN
AF Hsu, Pei-Sung
   Lin, Chia-Mo
   Chang, Jia-Feng
   Wu, Chi-Sheng
   Sia, Kee-Chin
   Lee, I-Ta
   Huang, Kuo-Yang
   Lin, Wei-Ning
TI Participation of NADPH Oxidase-Related Reactive Oxygen Species in
   Leptin-Promoted Pulmonary Inflammation: Regulation of cPLA2 and COX-2
   Expression
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE leptin; cPLA2; COX-2; ROS; c-Jun; inflammation
ID NF-KAPPA-B; ICAM-1 EXPRESSION; ADIPOSE-TISSUE; OBESITY; LUNG;
   ACTIVATION; INJURY; ADIPONECTIN; SECRETION; PM2.5
AB Obesity is a worldwide epidemic problem and correlates to varieties of acute or chronic lung diseases such as acute respiratory distress syndrome, chronic obstructive pulmonary disease, and pulmonary fibrosis. An increase of leptin, a kind of adipokine, in lean mice plasma has been found to impair immune responses and facilitate the infection of Klebsiella pneumoniae, resulting in increased pneumonia severity. Also, a higher leptin level is found in exhaled breath condensates of obese or asthmatic subjects, compared to healthy ones, suggesting that leptin is involved in the occurrence or exacerbation of lung injury. In previous studies, we showed that leptin stimulated cytosolic phospholipase A2- (cPLA2) gene expression in lung alveolar type II cells via mitogen-activated protein kinase (MAPK) and nuclear factor-kappa B (NF-B)-activated coactivator p300. Herein, we show that the in vivo application of leptin in the respiratory system upregulated the expression of inflammatory proteins cPLA2 and cyclooxygenase-2 (COX-2) together with leukocyte infiltration. Treatment with an ROS scavenger (N-acetylcysteine, NAC), an NADPH oxidase inhibitor (apocynin), or an activating protein (AP)-1 inhibitor (tanshinone IIA) attenuated leptin-mediated cPLA2/COX-2 expression and leukocyte recruitment in the lung. Leptin increased intracellular oxidative stress in a leptin receptor (OB-R) and NADPH oxidase-dependent manner, leading to the phosphorylation of the AP-1 subunit c-Jun. In summation, leptin increased lung cPLA2/COX-2 expression and leukocyte recruitment via the NADPH oxidase/ROS/AP-1 pathway. Understanding the inflammatory effects of leptin on the pulmonary system provides opportunities to develop strategies against lung injury related to metabolic syndrome or obesity.
C1 [Hsu, Pei-Sung; Lin, Chia-Mo] Shin Kong Wu Ho Su Mem Hosp, Div Chest Med, Taipei 111, Taiwan.
   [Lin, Chia-Mo] Fu Jen Catholic Univ, Dept Chem, New Taipei 242, Taiwan.
   [Chang, Jia-Feng] En Chu Kong Hosp, Dept Internal Med, New Taipei 237, Taiwan.
   [Lee, I-Ta] Taichung Vet Gen Hosp, Dept Med Res, Taichung 407, Taiwan.
   [Lee, I-Ta] Hungkuang Univ, Dept Nursing, Coll Nursing, Taichung 433, Taiwan.
   [Huang, Kuo-Yang] Natl Def Med Ctr, Grad Inst Pathol & Parasitol, Taipei 114, Taiwan.
   [Lin, Chia-Mo; Wu, Chi-Sheng; Sia, Kee-Chin; Lin, Wei-Ning] Fu Jen Catholic Univ, Grad Inst Biomed & Pharmaceut Sci, New Taipei 242, Taiwan.
C3 Shin Kong Wu Ho Su Memorial Hospital; Fu Jen Catholic University;
   Taichung Veterans General Hospital; Hungkuang University; National
   Defense Medical Center; Fu Jen Catholic University
RP Lin, WN (corresponding author), Fu Jen Catholic Univ, Grad Inst Biomed & Pharmaceut Sci, New Taipei 242, Taiwan.
EM pack14tw@gmail.com; aminus64@gmail.com; cjf6699@gmail.com;
   linweining@ms40.url.com.tw; abangsia3648@gmail.com; itl700128@gmail.com;
   cguhgy6934@gmail.com; 081551@mail.fju.edu.tw
RI Chang, Jia-Feng/AAW-1326-2020
FU Shin KongWu Ho-Su Memorial Hospital, Taiwan [103-SKH-FJU-02]; Fu Jen
   Catholic University Research Foundation, Taiwan [A0106010]
FX This work was supported by grants 103-SKH-FJU-02, from Shin KongWu Ho-Su
   Memorial Hospital, Taiwan; and A0106010, from Fu Jen Catholic University
   Research Foundation, Taiwan.
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NR 51
TC 23
Z9 27
U1 1
U2 17
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD MAR 1
PY 2019
VL 20
IS 5
AR 1078
DI 10.3390/ijms20051078
PG 15
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA HQ6QE
UT WOS:000462542300077
PM 30832310
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Bloksgaard, M
   Thorsted, B
   Brewer, JR
   De Mey, JGR
AF Bloksgaard, Maria
   Thorsted, Bjarne
   Brewer, Jonathan R.
   De Mey, Jo G. R.
TI Assessing Collagen and Elastin Pressure-dependent Microarchitectures in
   Live, Human Resistance Arteries by Label-free Fluorescence Microscopy
SO JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
LA English
DT Article
DE Bioengineering; Issue 134; Two-photon excitation fluorescence
   microscopy; extracellular matrix; image analyses; resistance arteries;
   Ilastik; Fiji; microstructure; mechanics; mathematical modeling
ID EXTRACELLULAR-MATRIX; FIBER ORIENTATIONS; OXIDATIVE STRESS; ABDOMINAL
   AORTAS; WALL MECHANICS; ORGANIZATION; MODEL; IMAGE
AB The pathogenic contribution of resistance artery remodeling is documented in essential hypertension, diabetes and the metabolic syndrome. Investigations and development of microstructurally motivated mathematical models for understanding the mechanical properties of human resistance arteries in health and disease have the potential to aid understanding how disease and medical treatments affect the human microcirculation. To develop these mathematical models, it is essential to decipher the relationship between the mechanical and microarchitectural properties of the microvascular wall. In this work, we describe an ex vivo method for passive mechanical testing and simultaneous label-free three-dimensional imaging of the microarchitecture of elastin and collagen in the arterial wall of isolated human resistance arteries. The imaging protocol can be applied to resistance arteries of any species of interest. Image analyses are described for quantifying i) pressure-induced changes in internal elastic lamina branching angles and adventitial collagen straightness using Fiji and ii) collagen and elastin volume densities determined using Ilastik software. Preferably all mechanical and imaging measurements are performed on live, perfused arteries, however, an alternative approach using standard video-microscopy pressure myography in combination with post-fixation imaging of re-pressurized vessels is discussed. This alternative method provides users with different options for analysis approaches. The inclusion of the mechanical and imaging data in mathematical models of the arterial wall mechanics is discussed, and future development and additions to the protocol are proposed.
C1 [Bloksgaard, Maria; De Mey, Jo G. R.] Univ Southern Denmark, Inst Mol Med, Dept Cardiovasc & Renal Res, Odense, Denmark.
   [Thorsted, Bjarne; Brewer, Jonathan R.] Univ Southern Denmark, Dept Biochem & Mol Biol, Odense, Denmark.
   [De Mey, Jo G. R.] Odense Univ Hosp, Dept Cardiac Thorac & Vasc Surg, Odense, Denmark.
C3 University of Southern Denmark; University of Southern Denmark;
   University of Southern Denmark; Odense University Hospital
RP Bloksgaard, M (corresponding author), Univ Southern Denmark, Inst Mol Med, Dept Cardiovasc & Renal Res, Odense, Denmark.
EM mbloksgaard@health.sdu.dk
RI Bloksgaard, Maria/Q-9761-2016; DeMey, Jo/KIB-5086-2024; Thorsted,
   Bjarne/B-2588-2014; Brewer, Jonathan/C-7079-2012
OI Bloksgaard, Maria/0000-0002-4474-9553; Thorsted,
   Bjarne/0000-0001-9743-1699; Brewer, Jonathan/0000-0002-3444-1715
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NR 52
TC 6
Z9 7
U1 0
U2 10
PU JOURNAL OF VISUALIZED EXPERIMENTS
PI CAMBRIDGE
PA 1 ALEWIFE CENTER, STE 200, CAMBRIDGE, MA 02140 USA
SN 1940-087X
J9 JOVE-J VIS EXP
JI J. Vis. Exp.
PD APR
PY 2018
IS 134
AR e57451
DI 10.3791/57451
PG 12
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA GS9OW
UT WOS:000444051300098
PM 29683445
OA Green Published
DA 2025-06-11
ER

PT J
AU Sanchez-Aguadero, N
   Mora-Simon, S
   Recio-Rodriguez, JI
   Alonso-Dominguez, R
   Gonzalez-Sanchez, J
   Martin-Martin, C
   Gomez-Marcos, MA
   Rodriguez-Sanchez, E
   Garcia-Ortiz, L
AF Sanchez-Aguadero, Natalia
   Mora-Simon, Sara
   Recio-Rodriguez, Jose I.
   Alonso-Dominguez, Rosario
   Gonzalez-Sanchez, Jesus
   Martin-Martin, Cristina
   Gomez-Marcos, Manuel A.
   Rodriguez-Sanchez, Emiliano
   Garcia-Ortiz, Luis
TI Effectiveness of an intensive intervention to improve lifestyles in
   people with intermediate cardiovascular risk (DATE study): Study
   protocol for a randomized controlled trial
SO JOURNAL OF ADVANCED NURSING
LA English
DT Article
DE cardiovascular diseases; cognitive performance; health education;
   lifestyle; nursing; quality of life; risk factors
ID HEALTH-CARE SETTINGS; QUALITY-OF-LIFE; PHYSICAL-ACTIVITY; MEDITERRANEAN
   DIET; METABOLIC SYNDROME; ASSOCIATION; PREVENTION; ADHERENCE;
   VALIDATION; OVERWEIGHT
AB Aim: The aim of this study was to evaluate the effectiveness of an intensive intervention led by primary care nurses for lifestyle modification among people with intermediate cardiovascular risk.
   Background: Cardiovascular diseases may be prevented by adopting healthy lifestyles. Interventions focused on populations at risk are more efficient than those aimed at the general population. More than 50 per cent of cardiovascular events occur in people with intermediate cardiovascular risk, but only a few studies have targeted this population.
   Design: A randomized controlled trial approved in January 2017.
   Methods: We will recruit 208 participants aged 35-74 years who have intermediate cardiovascular risk. They will be selected by consecutive sampling and will be randomized into a control group or intervention group. Individual standardized brief counselling on healthy lifestyles will be provided to both groups. Additionally, individuals from the intervention group will receive four weekly group sessions focusing on cardiovascular risk, healthy diet, moderation in alcohol consumption, daily physical activity, stress management and smoking cessation and two motivational followup calls. The primary outcome will be the lifestyle modification measured by total steps recorded by a pedometer, total score on the Mediterranean Diet Adherence Screener and percentage of current smokers.
   Discussion: This study will allow us to investigate whether an intensive intervention based on a multifactorial group approach is more effective in lifestyle modification than individual standardized brief counseling among adults with intermediate cardiovascular risk. Our results could lead to the establishment of new strategies for cardiovascular risk management.
C1 [Sanchez-Aguadero, Natalia; Alonso-Dominguez, Rosario; Martin-Martin, Cristina; Gomez-Marcos, Manuel A.; Rodriguez-Sanchez, Emiliano; Garcia-Ortiz, Luis] Biomed Res Inst Salamanca IBSAL, Castilla & Leon Hlth Serv SACYL, Alamedilla Hlth Ctr, Primary Care Res Unit, Salamanca, Spain.
   [Mora-Simon, Sara; Recio-Rodriguez, Jose I.; Gonzalez-Sanchez, Jesus] Biomed Res Inst Salamanca IBSAL, Alamedilla Hlth Ctr, Primary Care Res Unit, Salamanca, Spain.
   [Mora-Simon, Sara] Univ Salamanca, Dept Basic Psychol Psychobiol & Behav Sci Methodo, Salamanca, Spain.
   [Recio-Rodriguez, Jose I.] Univ Salamanca, Dept Nursing & Physiotherapy, Salamanca, Spain.
   [Gonzalez-Sanchez, Jesus] Univ Extremadura, Dept Nursing, Plasencia, Caceres, Spain.
   [Gomez-Marcos, Manuel A.; Rodriguez-Sanchez, Emiliano] Univ Salamanca, Dept Med, Salamanca, Spain.
   [Garcia-Ortiz, Luis] Univ Salamanca, Dept Biomed & Diagnost Sci, Salamanca, Spain.
C3 University of Salamanca; University of Salamanca; Universidad de
   Extremadura; University of Salamanca; University of Salamanca
RP Sanchez-Aguadero, N (corresponding author), Biomed Res Inst Salamanca IBSAL, Castilla & Leon Hlth Serv SACYL, Alamedilla Hlth Ctr, Primary Care Res Unit, Salamanca, Spain.
EM natalia.san.ag@gmail.com
RI Gonzalez-Sanchez, Jesus/AAA-8785-2020; Mora Simón, Sara/KCK-7730-2024;
   Sánchez-Aguadero, Natalia/L-3455-2019; Alonso-Domínguez,
   Rosario/AAB-5420-2021; Sanchez-Aguadero, Natalia/O-1811-2015;
   Rodriguez-Sanchez, Emiliano/N-5582-2014; Alonso-Dominguez,
   Rosario/H-2975-2017
OI Mora-Simon, Sara/0000-0003-2772-6971; Recio-Rodriguez, Jose
   I/0000-0002-3772-8746; Sanchez-Aguadero, Natalia/0000-0002-5816-1494;
   Gonzalez-Sanchez, Jesus/0000-0001-5453-2510; Rodriguez-Sanchez,
   Emiliano/0000-0003-3667-7155; Alonso-Dominguez,
   Rosario/0000-0002-5816-4070
FU Biomedical Research Institute of Salamanca [BIO16/00006]; Spanish
   Ministry of Science and Innovation (MICINN); Carlos III Health
   Institute/European Regional Development Fund (ISCIII/FEDER) (Network
   RedIAPP) [RD16/0007]; Autonomous Government of Castilla and Leon
   [BOCYL-D-06022017-1, ORDER SAN/360/2015]
FX The main funding has been granted by the Biomedical Research Institute
   of Salamanca through the 2016 announcement of grants for the performance
   of research projects in biomedicine, health management and social and
   health care (BIO16/00006). The trial has also been supported by grants
   funded by the Spanish Ministry of Science and Innovation (MICINN) and
   Carlos III Health Institute/European Regional Development Fund
   (ISCIII/FEDER) (Network RedIAPP RD16/0007) and Autonomous Government of
   Castilla and Leon through the 2017 intensification programme of nursing
   research activity (BOCYL-D-06022017-1) and the 2015 incentive programme
   of professional nurses completing their residency (ORDER SAN/360/2015).
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NR 53
TC 1
Z9 1
U1 0
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0309-2402
EI 1365-2648
J9 J ADV NURS
JI J. Adv. Nurs.
PD APR
PY 2018
VL 74
IS 4
BP 957
EP 967
DI 10.1111/jan.13503
PG 11
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA FY6ZW
UT WOS:000427012400021
PM 29148088
DA 2025-06-11
ER

PT J
AU de Melo, ISV
   dos Santos, AF
   Bueno, NB
AF Vieira de Melo, Ingrid Sofia
   dos Santos, Aldenir Feitosa
   Bueno, Nassib Bezerra
TI Curcumin or combined curcuminoids are effective in lowering the fasting
   blood glucose concentrations of individuals with dysglycemia: Systematic
   review and meta-analysis of randomized controlled trials
SO PHARMACOLOGICAL RESEARCH
LA English
DT Review
DE Curcuminoids; Curcumin; Turmeric extract; Fasting blood glucose;
   Dysglycemia
ID DOUBLE-BLIND; METABOLIC SYNDROME; OXIDATIVE STRESS; PLACEBO; EFFICACY;
   MARKERS; TETRAHYDROCURCUMIN; INFLAMMATION; THERAPY; EXTRACT
AB Curcuminoids have received considerable attention as therapeutical adjuvants in the treatment of dysglycemia. The purpose of this meta-analysis was to evaluate whether the supplementation of turmeric extract, curcuminoids and/or isolated curcumin is more effective than placebo in decreasing fasting blood glucose (FBG) in adults. MEDLINE, CENTRAL, ScienceDirect and gray literature databases were searched. Randomized controlled trials with the following criteria were included: (1) studied individuals older than 18 years, supplemented with curcumin, curcuminoids and/or turmeric extract (2) had a follow-up >= 4 weeks (3) used a placebo group. Titles and abstracts were screened and potentially eligible articles were retrieved. The primary outcome was FBG. The secondary outcomes were HbA(1c) and HOMA-IR. Eleven studies were included. In the overall analysis, turmeric, curcuminoids and curcumin supplementation led to a decrease in FBG (-8.88, 95% CI: [-5.04 to -2.72] mg/dL, p = 0.005). Supplementation of curcuminoids and/or curcumin decreased the concentrations of HbA1c (-0.54, 95% CI: [-1.09 to -0.002] %, p = 0.049) but were not able to decrease HOMA-IR (-1.26, 95% CI: [-3.71 to -1.19], p = 0.31). Sensitivity analyses revealed that baseline FBG was an important covariate. Heterogeneity was high in the overall analyses and there was evidence of publication bias. Supplementation of isolated curcumin or combined curcuminoids were both effective in lowering the FBG concentrations of individuals with some degree of dysglycemia, but not in non-diabetic individuals. Isolated curcumin lead to significant decreases of the HbA(1c) compared to placebo. (C) 2017 Elsevier Ltd. All rights reserved.
C1 [Vieira de Melo, Ingrid Sofia] Fed Inst Alagoas IFAL, Dept Agroind, BR 104,Km 107, Murici, Alagoas, Brazil.
   [dos Santos, Aldenir Feitosa] Univ Ctr Maceio CESMAC, St Conego Machado,918 Farol, Maceio, Alagoas, Brazil.
   [Bueno, Nassib Bezerra] Fed Univ Alagoas UFAL, Fac Nutr, Ave Lourival Melo Mota, Maceio, Alagoas, Brazil.
C3 Instituto Federal de Alagoas (IFAL); Universidade Federal de Alagoas
RP de Melo, ISV (corresponding author), BR 104,Km 107, BR-57820000 Murici, Alagoas, Brazil.
EM ingridsofia.melo@hotmail.com; aldenirfeitosa@gmail.com;
   nassib.bueno@fanut.ufal.br
RI Bueno, Nassib/P-8057-2018
OI Bueno, Nassib/0000-0002-3286-0297
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NR 42
TC 43
Z9 43
U1 0
U2 18
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 1043-6618
J9 PHARMACOL RES
JI Pharmacol. Res.
PD FEB
PY 2018
VL 128
BP 137
EP 144
DI 10.1016/j.phrs.2017.09.010
PG 8
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA GJ8GE
UT WOS:000435626500015
PM 28928074
DA 2025-06-11
ER

PT J
AU Argente-Arizon, P
   Díaz, F
   Ros, P
   Barrios, V
   Tena-Sempere, M
   García-Segura, LM
   Argente, J
   Chowen, JA
AF Argente-Arizon, Pilar
   Diaz, Francisca
   Ros, Purificacion
   Barrios, Vicente
   Tena-Sempere, Manuel
   Miguel Garcia-Segura, Luis
   Argente, Jesus
   Chowen, Julie A.
TI The Hypothalamic Inflammatory/Gliosis Response to Neonatal Overnutrition
   Is Sex and Age Dependent
SO ENDOCRINOLOGY
LA English
DT Article
ID PLASMA FATTY-ACID; ENDOPLASMIC-RETICULUM STRESS; INSULIN-RESISTANCE;
   FOOD-INTAKE; ESTROGEN-RECEPTOR; ENERGY HOMEOSTASIS; METABOLIC SYNDROME;
   POSTNATAL LEPTIN; ALPHA PRODUCTION; GENE-EXPRESSION
AB Astrocytes participate in both physiological and pathophysiological responses to metabolic and nutrient signals. Although most studies have focused on the astrocytic response to weight gain due to high-fat/high-carbohydrate intake, surplus intake of a balanced diet also induces excess weight gain. We have accessed the effects of neonatal overnutrition, which has both age- and sex-dependent effects on weight gain, on hypothalamic inflammation/gliosis. Although both male and female Wistar rats accumulate excessive fat mass as early as postnatal day (PND) 10 with neonatal overnutrition, no increase in hypothalamic cytokine levels, markers of astrocytes or microglia, or inflammatory signaling pathways were observed. At PND 50, no effect of neonatal overnutriton was found in either sex, whereas at PND 150, males again weighed significantly more than their controls, and this was coincident with an increase in markers of inflammation and astrogliosis in the hypothalamus. Circulating triglycerides and free fatty acids were also elevated in these males, but not in females or in either sex at PND 10. Thus, the effects of fatty acids and estrogens on astrocytes in vitro were analyzed. Our results indicate that changes in circulating fatty acid levels may be involved in the induction of hypothalamic inflammation/gliosis in excess weight gain, even on a normal diet, and that estrogens could participate in the protection of females from these processes. In conclusion, the interaction of developmental influences, dietary composition, age, and sex determines the central inflammatory response and the associated long-term outcomes of excess weight gain.
C1 [Argente-Arizon, Pilar; Diaz, Francisca; Barrios, Vicente; Argente, Jesus; Chowen, Julie A.] Hosp Infantil Univ Nino Jesus, Inst Invest Princesa, Dept Endocrinol, Madrid 28009, Spain.
   [Argente-Arizon, Pilar; Ros, Purificacion; Argente, Jesus] Univ Autonoma Madrid, Fac Med, Dept Pediat, E-28029 Madrid, Spain.
   [Argente-Arizon, Pilar; Diaz, Francisca; Barrios, Vicente; Tena-Sempere, Manuel; Argente, Jesus; Chowen, Julie A.] Inst Carlos III, Ctr Invest Biomed Red Fisiopatol Obesidad & Nutr, Madrid 28029, Spain.
   [Ros, Purificacion] Hosp Univ Puerto Hierro Majadahonda, Madrid 28222, Spain.
   [Tena-Sempere, Manuel] Univ Cordoba, Inst Maimonides Invest Biomed Cordoba, Dept Cell Biol Physiol & Immunol, E-14004 Cordoba, Spain.
   [Miguel Garcia-Segura, Luis] Inst Carlos III, Ctr Invest Biomed Red Fragilidad & Envejecimiento, CSIC, Inst Cajal, Madrid 28008, Spain.
   [Argente, Jesus] Univ Autonoma Madrid, CSIC, Inst Madrileno Estudios, Svanzados Food Inst, Campus Excelencia Int, E-28049 Madrid, Spain.
C3 Autonomous University of Madrid; CIBER - Centro de Investigacion
   Biomedica en Red; CIBEROBN; Universidad de Cordoba; Consejo Superior de
   Investigaciones Cientificas (CSIC); CSIC - Instituto Cajal (IC); CIBER -
   Centro de Investigacion Biomedica en Red; CIBERFES; Consejo Superior de
   Investigaciones Cientificas (CSIC); Autonomous University of Madrid
RP Chowen, JA (corresponding author), Hosp Infantil Univ Nino Jesus, Dept Endocrinol, Ave Menendez Pelayo 65, Madrid 28009, Spain.
EM julieann.chowen@salud.madrid.org
RI Argente, Jesús/M-5226-2019; Ros-Pérez, Purificación/KMY-5915-2024;
   Barrios Sabador, Vicente/N-6982-2016; Tena-Sempere,
   Manuel/AAX-3602-2021; Garcia-Segura, Luis/U-3711-2017; Tena-Sempere,
   Manuel/K-8419-2014; Chowen, Julie/C-8979-2011; Argente Arizon,
   Pilar/K-1153-2014
OI Tena-Sempere, Manuel/0000-0002-4741-5567; Diaz-Gonzalez,
   Francisca/0000-0003-1364-7586; Chowen, Julie/0000-0002-4770-2291; Ros
   Perez, Purificacion/0009-0001-3764-4980; Argente Arizon,
   Pilar/0000-0002-8013-3828
FU Spanish Ministry of Science and Innovation [BFU2014-51836-C2-2,
   BFU2014-51836-C2-1]; Fondo de Investigacion Sanitaria [PI-1302195,
   PI16/00485]; Fondo de Investigacion Sanitaria (Centro de Investigacion
   Biomedica en Red: Fisiopatologia de la Obesidad y Nutricion); Fondo de
   Investigacion Sanitaria (Centro de Investigacion Biomedica en Red de
   Fragilidad y Envejecimiento Saludable); Fondo Europeo de Desarrollo
   Regional
FX This work was supported by grants from the Spanish Ministry of Science
   and Innovation (BFU2014-51836-C2-2 to J.A.C. and BFU2014-51836-C2-1 to
   L.M.G.-S.), Fondo de Investigacion Sanitaria (PI-1302195 and PI16/00485
   to J.A., Centro de Investigacion Biomedica en Red: Fisiopatologia de la
   Obesidad y Nutricion to J.A. and M.T.-S., and Centro de Investigacion
   Biomedica en Red de Fragilidad y Envejecimiento Saludable to L.M.G.-S.),
   and Fondo Europeo de Desarrollo Regional.
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NR 127
TC 37
Z9 37
U1 0
U2 6
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0013-7227
EI 1945-7170
J9 ENDOCRINOLOGY
JI Endocrinology
PD JAN
PY 2018
VL 159
IS 1
BP 368
EP 387
DI 10.1210/en.2017-00539
PG 20
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA FS3QM
UT WOS:000419697300030
PM 29077836
OA Bronze
DA 2025-06-11
ER

PT J
AU Seoung, JY
   Lee, SW
   Kang, YM
   Kim, MJ
   Park, JM
   Moon, HM
   Rhim, CC
AF Seoung, Jung Yeob
   Lee, Suk Woo
   Kang, Young Mo
   Kim, Min Jung
   Park, Jae Min
   Moon, Hye Min
   Rhim, Chae Chun
TI Association between metabolic risks and bone mineral density in
   postmenopausal women
SO CLINICAL AND EXPERIMENTAL OBSTETRICS & GYNECOLOGY
LA English
DT Article
DE Adipokine; Bone mineral density; Metabolic syndrome; Osteocalcin;
   Postmenopause
ID INSULIN-RESISTANCE; OXIDATIVE STRESS; ENERGY-METABOLISM; OSTEOPOROSIS;
   INFLAMMATION; DISEASE; FAT; ADIPONECTIN; MENOPAUSE; SKELETON
AB Background: Menopause is associated with osteoporosis and an increased risk of metabolic disorders, including obesity, abdominal adiposity, hyperlipidemia, hypertension, and insulin resistance, which may increase the risk of cardiovascular disease (CVD). Recent studies have demonstrated a correlation between fat, glucose, and bone metabolism which could contribute to CVD and osteoporosis. This study examined the association between metabolic risk factors and bone mineral density (BMD) in postmenopausal women. Materials and Methods: The authors determined the anthropometric values [waist-hip ratio (WHR), visceral fat area (VFA), body fat mass (BFM), and skeletal muscle mass (SMM)], lipid profile, fasting plasma glucose levels, high-sensitivity C-reactive protein levels, homeostasis model assessment of insulin resistance (HOMA-IR) scores, serum leptin and adiponectin levels, serum osteocalcin level [total osteocalcin (tOC) and undercarboxylated osteocalcin (ucOC)], and BMDs of the lumbar spine and femoral neck in 137 postmenopausal women. Results: There was a positive correlation between BFM, HOMA-IR score, serum leptin level, and BMD of the lumbar spine, and a negative correlation between BFM, total cholesterol, serum adiponectin, and BMD of the lumbar spine after adjusting for age, years since menopause, current alcohol consumption, and current smoking status. In a multiple regression analysis, serum adiponectin level and SMM were the most important predictors of the BMD of the lumbar spine. Conclusion: There were several metabolic risk variables that had a harmful effect on the BMD of the lumbar spine, but not the femoral neck. However, higher serum adiponectin levels were negatively correlated with BMD of the lumbar spine as adiposity decreased.
C1 [Seoung, Jung Yeob; Lee, Suk Woo; Kang, Young Mo; Kim, Min Jung; Park, Jae Min; Rhim, Chae Chun] Hallym Univ, Coll Med, Sacred Heart Hosp, Dept Obstet & Gynecol, 22 Gwanpyeong Ro 170 Beon Gil, Anyang 431796, Gyeonggi Do, South Korea.
   [Moon, Hye Min] Catholic Univ Korea, Coll Med, Dept Obstet & Gynecol, Seoul, South Korea.
C3 Hallym University; Catholic University of Korea
RP Rhim, CC (corresponding author), Hallym Univ, Coll Med, Sacred Heart Hosp, Dept Obstet & Gynecol, 22 Gwanpyeong Ro 170 Beon Gil, Anyang 431796, Gyeonggi Do, South Korea.
EM ccrhim@hallym.or.kr
RI Lee, Suk/U-9987-2019; Li, Shaofu/O-2241-2019
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NR 39
TC 3
Z9 3
U1 0
U2 6
PU I R O G CANADA, INC
PI MONTREAL
PA 4900 COTE ST-LUC, APT#212, MONTREAL, QUEBEC H3W 2H3, CANADA
SN 0390-6663
J9 CLIN EXP OBSTET GYN
JI Clin. Exp. Obstet. Gynecol.
PY 2018
VL 45
IS 5
BP 671
EP 676
DI 10.12891/ceog4341.2018
PG 6
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA GT3FD
UT WOS:000444385100006
OA Bronze
DA 2025-06-11
ER

PT J
AU Chi, GC
   Fitzpatrick, AL
   Sharma, M
   Jenny, NS
   Lopez, OL
   DeKosky, ST
AF Chi, Gloria C.
   Fitzpatrick, Annette L.
   Sharma, Monisha
   Jenny, Nancy S.
   Lopez, Oscar L.
   DeKosky, Steven T.
TI Inflammatory Biomarkers Predict Domain-Specific Cognitive Decline in
   Older Adults
SO JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL
   SCIENCES
LA English
DT Article
DE Inflammation; Cognitive decline; Vascular; Biomarkers; Longitudinal
ID SERUM-AMYLOID-P; C-REACTIVE PROTEIN; CARDIOVASCULAR-DISEASE;
   ALZHEIMERS-DISEASE; PENTRAXIN 3; METABOLIC SYNDROME; DEMENTIA;
   IMPAIRMENT; COMPONENT; HEALTH
AB Background: Vascular risk factors, including inflammation, may contribute to dementia development. We investigated the associations between peripheral inflammatory biomarkers and cognitive decline in five domains (memory, construction, language, psychomotor speed, and executive function).
   Methods: Community-dwelling older adults from the Ginkgo Evaluation of Memory Study (n = 1,159, aged 75 or older) free of dementia at baseline were included and followed for up to 7 years. Ten biomarkers were measured at baseline representing different sources of inflammation: vascular inflammation (pentraxin 3 and serum amyloid P), endothelial function (endothelin-1), metabolic function (adiponectin, resistin, and plasminogen activating inhibitor-1), oxidative stress (receptor for advanced glycation end products), and general inflammation (interleukin-6, interleukin-2, and interleukin-10). A combined z-score was created from these biomarkers to represent total inflammation across these sources. We utilized generalized estimating equations that included an interaction term between z-scores and time to assess effect of inflammation on cognitive decline, adjusting for demographics (such as age, race/ethnicity, and sex), cardiovascular risk factors, and apolipoprotein E e4 carrier status. A Bonferroni-adjusted significance level of.01 was used. We explored associations between individual biomarkers and cognitive decline without adjustment for multiplicity.
   Results: The combined inflammation z-score was significantly associated with memory and psychomotor speed (p <.01). Pentraxin 3, serum amyloid P, endothelin-1, and interleukin-2 were associated with change in at least one cognitive domain (p <.05).
   Conclusion: Our results suggest that total inflammation is associated with memory and psychomotor speed. In particular, systemic inflammation, vascular inflammation, and altered endothelial function may play roles in domain-specific cognitive decline of nondemented individuals.
C1 [Chi, Gloria C.; Fitzpatrick, Annette L.; Sharma, Monisha] Univ Washington, Sch Publ Hlth, Dept Epidemiol, 1959 NE Pacific St,Box 357236, Seattle, WA 98195 USA.
   [Fitzpatrick, Annette L.] Univ Washington, Sch Med, Dept Family Med, Seattle, WA 98195 USA.
   [Fitzpatrick, Annette L.] Univ Washington, Sch Publ Hlth, Dept Global Hlth, Seattle, WA 98195 USA.
   [Jenny, Nancy S.] Univ Vermont, Sch Med, Dept Pathol & Lab Med, Burlington, VT 05405 USA.
   [Lopez, Oscar L.] Univ Pittsburgh, Sch Med, Dept Neurol, Pittsburgh, PA 15260 USA.
   [DeKosky, Steven T.] Univ Florida, Coll Med, McKnight Brain Inst, Gainesville, FL USA.
   [DeKosky, Steven T.] Univ Florida, Coll Med, Dept Neurol, Gainesville, FL 32611 USA.
C3 University of Washington; University of Washington Seattle; University
   of Washington; University of Washington Seattle; University of
   Washington; University of Washington Seattle; University of Vermont;
   Pennsylvania Commonwealth System of Higher Education (PCSHE); University
   of Pittsburgh; State University System of Florida; University of
   Florida; State University System of Florida; University of Florida
RP Chi, GC (corresponding author), Univ Washington, Sch Publ Hlth, Dept Epidemiol, 1959 NE Pacific St,Box 357236, Seattle, WA 98195 USA.
EM glochi@uw.edu
RI Lopez, Oscar/ACC-1861-2022; DeKosky, Steven/AEK-8044-2022
OI DeKosky, Steven/0000-0003-3743-2758
FU National Center for Complementary and Integrative Health (NCCIH) [R01
   AT006668, 5 U01 AT000162]; National Institute of Environmental Health
   Sciences [1F31ES025475-01]; National Institute on Aging, National Heart,
   Lung, and Blood Institute; University of Pittsburgh Alzheimer's Disease
   Research Center [P50AG05133]; University of Florida 1-Florida [ADRC
   P50-AG047266]; Roena Kulynych Center for Memory and Cognition Research;
   National Institute of Neurological Disorders and Stroke; National
   Institute on Aging (NIA) [U24 AG21886]
FX This work was supported by the National Center for Complementary and
   Integrative Health (NCCIH, previously National Center for Complementary
   and Alternative Medicine [NCCAM], grant numbers R01 AT006668 and 5 U01
   AT000162); National Institute of Environmental Health Sciences (grant
   number 1F31ES025475-01); National Institute on Aging, National Heart,
   Lung, and Blood Institute; the University of Pittsburgh Alzheimer's
   Disease Research Center (grant number P50AG05133); the University of
   Florida 1-Florida (ADRC P50-AG047266); the Roena Kulynych Center for
   Memory and Cognition Research; and the National Institute of
   Neurological Disorders and Stroke. Samples from the National Cell
   Repository for Alzheimer's Disease (NCRAD), which receives government
   support under a cooperative agreement grant (U24 AG21886) awarded by the
   National Institute on Aging (NIA), were used in this study. The contents
   are solely the responsibility of the authors and do not necessarily
   represent the official views of the NCCIH, or the National Institutes of
   Health, or any other funder.
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NR 43
TC 45
Z9 54
U1 1
U2 14
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1079-5006
EI 1758-535X
J9 J GERONTOL A-BIOL
JI J. Gerontol. Ser. A-Biol. Sci. Med. Sci.
PD JUN
PY 2017
VL 72
IS 6
BP 796
EP 803
DI 10.1093/gerona/glw155
PG 8
WC Geriatrics & Gerontology; Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA EZ7CM
UT WOS:000404877800010
PM 27522059
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Yamada-Obara, N
   Yamagishi, S
   Taguchi, K
   Kaida, Y
   Yokoro, M
   Nakayama, Y
   Ando, R
   Asanuma, K
   Matsui, T
   Ueda, S
   Okuda, S
   Fukami, K
AF Yamada-Obara, Nana
   Yamagishi, Sho-ichi
   Taguchi, Kensei
   Kaida, Yusuke
   Yokoro, Miyuki
   Nakayama, Yosuke
   Ando, Ryotaro
   Asanuma, Katsuhiko
   Matsui, Takanori
   Ueda, Seiji
   Okuda, Seiya
   Fukami, Kei
TI Maternal exposure to high-fat and high-fructose diet evokes
   hypoadiponectinemia and kidney injury in rat offspring
SO CLINICAL AND EXPERIMENTAL NEPHROLOGY
LA English
DT Article
DE Adiponectin; Maternal diet; Albuminuria; Hypertension; Renal injury
ID SERUM ADIPONECTIN LEVELS; DIABETIC-NEPHROPATHY; METABOLIC SYNDROME;
   KNOCKOUT MICE; BIRTH-WEIGHT; OBESITY; DISEASE; ALBUMINURIA; DYSFUNCTION;
   RISK
AB Maternal exposure to overnutrition during fetal development contributes to metabolic and renal damage in offspring. Adiponectin plays a protective role against obesity-related renal injury. However, role of adiponectin in renal injury of offspring exposed to maternal overnutrition remains unknown. We addressed the issue.
   Female Sprague-Dawley rats were fed either a standard (N) or a high-fat and high-fructose (HFF)-diet for 6 weeks before mating, and kept each diet during the gestation and lactation period. After 4 weeks postpartum, all the offspring were fed N diet, and followed by 12 weeks. Kidney weight, urinary albumin excretion, blood pressure, and blood chemistry, including adiponectin and malondialdehyde, a marker of oxidative stress, were evaluated in the offspring.
   Compared with N-offspring, serum adiponectin levels of 1-day- and 4-week-old HFF-offspring were significantly lower, the latter of which was inversely associated with malondialdehyde. Kidney weight was significantly decreased in 1-day-old HFF-offspring, whereas increased in 4-week-old HFF-offspring. Urinary albumin excretion levels of HFF-offspring at 8, 12, and 16-week old were significantly higher than those of N-offspring at the same age, whose levels at 16-week old were inversely correlated with plasma adiponectin. Compared with N-offspring, HFF-offspring at 16-week old exhibited glomerulosclerosis, hyperglycemia, and high mean blood pressure associated with reduced podocin and increased transforming growth factor-beta 1 expression in the kidneys.
   Our present study suggests that exposure to maternal HFF-diet during fetal and early postnatal development induces hypoadiponectinemia in offspring, which might cause renal injury and metabolic derangements later in life.
C1 [Yamada-Obara, Nana; Taguchi, Kensei; Kaida, Yusuke; Yokoro, Miyuki; Nakayama, Yosuke; Ando, Ryotaro; Ueda, Seiji; Okuda, Seiya; Fukami, Kei] Kurume Univ, Sch Med, Dept Med, Div Nephrol, 67 Asahi Machi, Kurume, Fukuoka 8300011, Japan.
   [Yamagishi, Sho-ichi; Matsui, Takanori] Kurume Univ, Sch Med, Dept Pathophysiol & Therapeut Diabet Vasc Complic, Kurume, Fukuoka, Japan.
   [Asanuma, Katsuhiko] Kyoto Univ, Grad Sch Med, Med Innovat Ctr, TMK Project, Kyoto, Japan.
C3 Kurume University; Kurume University; Kyoto University
RP Fukami, K (corresponding author), Kurume Univ, Sch Med, Dept Med, Div Nephrol, 67 Asahi Machi, Kurume, Fukuoka 8300011, Japan.
EM fukami@med.kurume-u.ac.jp
RI Taguchi, Kensei/AAN-6539-2021
OI Matsui, Takanori/0000-0001-9506-7571; Yokoro-Hisanari,
   Miyuki/0000-0002-9284-0175
FU Ministry of Education, Culture, Sports, Science and Technology of Japan
   [22590904]; MEXT; Grants-in-Aid for Scientific Research [22590904,
   16K19502] Funding Source: KAKEN
FX This work was supported, in part, by Grants-inAid for Welfare and
   Scientific Research (C) (No. 22590904) (K. F) and from the Ministry of
   Education, Culture, Sports, Science and Technology of Japan, and by
   MEXT-Supported Program for the Strategic Research Foundation at Private
   Universities, the Ministry of Education, Culture, Sports, Science and
   Technology (MEXT) (S. Y).
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NR 30
TC 19
Z9 22
U1 0
U2 8
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1342-1751
EI 1437-7799
J9 CLIN EXP NEPHROL
JI Clin. Exp. Nephrol.
PD DEC
PY 2016
VL 20
IS 6
BP 853
EP 861
DI 10.1007/s10157-016-1265-9
PG 9
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA EE2IO
UT WOS:000389407600005
PM 27179663
DA 2025-06-11
ER

PT J
AU Jankiewicz, AKC
   Peredo, SMR
   Saldaña, GC
   Díaz, ED
   Barrera, MET
   Plata, LD
   Zabala, RC
AF Castellanos Jankiewicz, Ashley Kate
   Rodriguez Peredo, Sofia Montserrat
   Cardoso Saldana, Guillermo
   Diaz Diaz, Eulises
   Tejero Barrera, Maria Elizabeth
   del Bosque Plata, Laura
   Carbo Zabala, Roxana
TI Adipose tissue redistribution caused by an early consumption of a high
   sucrose diet in a rat model
SO NUTRICION HOSPITALARIA
LA English
DT Article
DE Nutrition; Adipose tissue; Bioelectrical impedance; Sucrose; Obesity
ID METABOLIC SYNDROME; INSULIN-RESISTANCE; BODY-WEIGHT; GLUCOSE;
   ADIPONECTIN; OBESITY; ACCUMULATION; ASSOCIATION; STRESS; LEPTIN
AB Introduction: obesity is a major public health problem worldwide. The quantity and site of accumulation of adipose tissue is of great importance for the physiopathology of this disease.
   Objectives: the aim of this study was to assess the effect of a high carbohydrate diet on adipose tissue distribution.
   Methods: male Wistar rats, control (CONT) and high sucrose diet (HSD; 30% sucrose in their drinking water), were monitored during 24 weeks and total energy and macronutrient intake were estimated by measuring daily average consumption. A bioelectrical impedance procedure was performed at 22 weeks of treatment to assess body compartments and systolic arterial blood pressure was measured. Serum was obtained and retroperitoneal adipose tissue was collected and weighed.
   Results: HSD ingested less pellets and beverage, consuming less lipids and proteins than CONT, but the same amount of carbohydrates. Retroperitoneal adipose tissue was more abundant in HSD. Both groups were normoglycemic; triglycerides, adiponectin and leptin levels were higher, while total cholesterol and HDL-cholesterol were lower in HSD; insulin, HOMA index and systolic blood pressure had a tendency of being higher in HSD.
   Discussion: this model presents dyslipidemia and a strong tendency for insulin resistance and hypertension. Even though there was no difference in body compartments between groups, retroperitoneal adipose tissue was significantly increased in HSD. This suggests that a rearrangement of adipose tissue distribution towards the abdominal cavity takes place as a result of chronic high sucrose consumption, which contributes to a higher risk of suffering from metabolic and chronic degenerative diseases.
C1 [Castellanos Jankiewicz, Ashley Kate; Rodriguez Peredo, Sofia Montserrat; Tejero Barrera, Maria Elizabeth; del Bosque Plata, Laura] Natl Inst Genom Med, Lab Nutrigen & Nutrigenet, Tlalpan 14610, Mexico.
   [Rodriguez Peredo, Sofia Montserrat] Natl Polytech Inst, Natl Sch Biol Sci, Col Santo Tomas 11340, Miguel Hidalgo, Mexico.
   [Cardoso Saldana, Guillermo] Natl Inst Cardiol Ignacio Chavez, Dept Endocrinol, Tlalpan 14080, Mexico.
   [Diaz Diaz, Eulises] Natl Inst Med Sci & Nutr Salvador Zurbiran, Dept Reprod Biol, Tlalpan 14080, Mexico.
   [Carbo Zabala, Roxana] Inst Nacl Cardiol Ignacio Chavez, Dept Biomed Cardiovasc, Mexico City 14080, DF, Mexico.
C3 Instituto Nacional de Medicina Genomica; Instituto Politecnico Nacional
   - Mexico; National Institute of Cardiology - Mexico; National Institute
   of Cardiology - Mexico
RP Zabala, RC (corresponding author), Inst Nacl Cardiol Ignacio Chavez, Dept Biomed Cardiovasc, Juan Badiano 1,Col Sec 16, Mexico City 14080, DF, Mexico.
EM roxcarbo@gmail.com
OI Castellanos, Ashley/0000-0001-9080-7593; del Bosque-Plata,
   Laura/0000-0003-3224-378X
FU Coordinating Committee of National Institutes of Health and High
   Specialty Hospitals (PROBEI); National Council for Science and
   Technology (CONACYT) [230762]
FX The authors acknowledge financial support to A.K.C.J., who received a
   scholarship from the Coordinating Committee of National Institutes of
   Health and High Specialty Hospitals (PROBEI) and S.M.R.P., who received
   a PhD. scholarship from the National Council for Science and Technology
   (CONACYT # 230762).
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NR 34
TC 12
Z9 15
U1 1
U2 9
PU ARAN EDICIONES, S L
PI MADRID
PA C/ CASTELLO, 128, 1O, MADRID, 28006, SPAIN
SN 0212-1611
EI 1699-5198
J9 NUTR HOSP
JI Nutr. Hosp.
PD JUN
PY 2015
VL 31
IS 6
BP 2546
EP 2553
DI 10.3305/nh.2015.31.6.8935
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA CK0KV
UT WOS:000355895000028
PM 26040364
DA 2025-06-11
ER

PT J
AU Garcez, AD
   Canuto, R
   Paniz, VMV
   Olinto, BA
   Macagnan, J
   Henn, RL
   Pattussi, MP
   Olinto, MTA
AF Garcez, Anderson da Silva
   Canuto, Raquel
   Vieira Paniz, Vera Maria
   Olinto, Beatriz Anselmo
   Macagnan, Jamile
   Henn, Ruth Liane
   Pattussi, Marcos Pascoal
   Anselmo Olinto, Maria Teresa
TI Association between work shift and the practice of physical activity
   among workers of a poultry processing plant in Southern Brazil
SO NUTRICION HOSPITALARIA
LA English
DT Article
DE Physical activity; Shift work
ID METABOLIC SYNDROME; HEALTH; LEISURE; DISEASE; PREVALENCE; EXERCISE;
   STRESS; IMPACT
AB Introduction: The regular practice of physical activity (PA) has been associated with better health. In addition, job characteristics may determine the PA behaviours of employees, including the work shift. However, relatively few studies have examined the PA behaviour among shift workers.
   Objective: This study aimed to investigate the association between work shift and the practice of PA among workers of a poultry processing plant in Southern Brazil.
   Methods: A cross-sectional study was conducted with 1206 workers (786 females), ages 18 to 50, working in shifts on a production line that operates 24 hours/day. Workers who engaged in more than 150 minutes/week of PA were considered active. Multivariate analyses were conducted using Poisson regression and all analyses were stratified by gender.
   Results: Of the total participants studied, 36% (95%CI: 33-39) were considered active and the sociodemographic characteristics associated with PA differed among males and females. Regarding work shift, night shift workers had higher prevalence of PA. However, increased PA was significantly associated with work shift particularly among females. After controlling for potential confounders, women who worked during the night shift were approximately 30% more active than those who worked during the day (PR[prevalence ratio]=1.32;95%CI: 1.07-1.62;p=0.010).
   Conclusions: This study found a low prevalence of PA among the workers and indicated a significantly association between work shift and PA. Working at night was positively associated with regular PA, particularly among females. These results contribute for initiatives that aim to increase PA among the workers, take into account the job characteristics and gender differences.
C1 [Garcez, Anderson da Silva; Vieira Paniz, Vera Maria; Macagnan, Jamile; Henn, Ruth Liane; Pattussi, Marcos Pascoal; Anselmo Olinto, Maria Teresa] Univ Vale do Rio dos Sinos, Postgrad Program Collect Hlth, BR-93022000 Sao Leopoldo, RS, Brazil.
   [Canuto, Raquel] Fed Univ Rio Grande do Sul State, Dept Nutr, Porto Alegre, RS, Brazil.
   [Olinto, Beatriz Anselmo] Univ Estadual Centro Oeste, Postgrad Program Hist, Guarapuava, Parana, Brazil.
   [Anselmo Olinto, Maria Teresa] Fed Univ Hlth Sci Porto Alegre, Dept Nutr, Porto Alegre, RS, Brazil.
C3 Universidade Federal do Rio Grande do Sul; Universidade Estadual do
   Centro Oeste
RP Olinto, MTA (corresponding author), Univ Vale do Rio dos Sinos, Postgrad Program Collect Hlth, Ave Unisinos 950,CP 275, BR-93022000 Sao Leopoldo, RS, Brazil.
EM mtolinto@gmail.com
RI Olinto, Maria/AAH-5897-2021; Paniz, Vera/AAJ-8450-2020; Pattussi,
   Marcos/P-1730-2019; Garcez, Anderson/AAH-5877-2021; Canuto,
   Raquel/AAV-8688-2020
OI Canuto, Raquel/0000-0002-4042-1913
FU National Council of Technological and Scientific Development (CNPq)
   [477069/2009-6]; CNPq [304793/2010-8, 303424/2011-7]; Brazilian Federal
   Agency for Support and Evaluation of Graduated Education - CAPES
FX This work was supported by the National Council of Technological and
   Scientific Development (CNPq; grant 477069/2009-6). The authors received
   research productivity grants from CNPq (grant 304793/2010-8 to M.T.A.O
   and grant 303424/2011-7 to M.P.P.) and scholarships from Brazilian
   Federal Agency for Support and Evaluation of Graduated Education - CAPES
   to A.S.G. and R.C. The funding agencies had no role in the study design,
   data collection and analysis, decision to publish or preparation or
   approval of the manuscript.
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NR 39
TC 13
Z9 13
U1 0
U2 14
PU ARAN EDICIONES, S L
PI MADRID
PA C/ CASTELLO, 128, 1O, MADRID, 28006, SPAIN
SN 0212-1611
EI 1699-5198
J9 NUTR HOSP
JI Nutr. Hosp.
PD MAY
PY 2015
VL 31
IS 5
BP 2174
EP 2181
DI 10.3305/nh.2015.31.5.8628
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA CH7QH
UT WOS:000354231200035
PM 25929390
DA 2025-06-11
ER

PT J
AU De Ciuceis, C
   Flati, V
   Rossini, C
   Rufo, A
   Porteri, E
   Di Gregorio, J
   Petroboni, B
   La Boria, E
   Donini, C
   Pasini, E
   Rosei, EA
   Rizzoni, D
AF De Ciuceis, Carolina
   Flati, Vincenzo
   Rossini, Claudia
   Rufo, Anna
   Porteri, Enzo
   Di Gregorio, Jacopo
   Petroboni, Beatrice
   La Boria, Elisa
   Donini, Carlotta
   Pasini, Evasio
   Rosei, Enrico Agabiti
   Rizzoni, Damiano
TI Effect of antihypertensive treatments on insulin signalling in
   lympho-monocytes of essential hypertensive patients: A pilot study
SO BLOOD PRESSURE
LA English
DT Article
DE Insulin signalling; Telmisartan; nifedipine; lercanidipine; enalapril
   hydrochlorothiazide; mTOR; GLUT-4; insulin lymphocites; monocytes
ID CONVERTING-ENZYME-INHIBITORS; SKELETAL-MUSCLE; HIGH-RISK; THROMBOTIC
   MICROANGIOPATHY; RESISTANCE; PATHWAY; HYPERINSULINEMIA; INFLAMMATION;
   TELMISARTAN; ACTIVATION
AB It was previously demonstrated that metabolic syndrome in humans is associated with an impairment of insulin signalling in circulating mononuclear cells. At least in animal models of hypertension, angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARB) may correct alterations of insulin signalling in the skeletal muscle. In the first study, we investigated the effects of a 3-month treatment with an ARB with additional PPAR. agonist activity, telmisartan, or with a dihydropyridine calcium channel blocker, nifedipine, on insulin signalling in patients with mild-moderate essential hypertension. Insulin signalling was evaluated in mononuclear cells by isolating them through Ficoll-Paque density gradient centrifugation and protein analysis by Western Blot. An increased expression of mTOR and of phosphorylated (active) mTOR (p-mTOR) was observed in patients treated with telmisartan, but not in those treated with nifedipine, while both treatments increased the cellular expression of glucose transporter type 4 (GLUT-4). We also investigated the effects of antihypertensive treatment with two drug combinations on insulin signalling and oxidative stress. Twenty essential hypertensive patients were included in the study and treated for 4 weeks with lercanidipine. Then they were treated for 6 months with lercanidipine + enalapril or lercanidipine + hydrochlorothiazide. An increased expression of insulin receptor, GLUT-4 and an increased activation of p70S6K1 were observed during treatment with lercanidipine + enalapril but not with lercanidipine + hydrochlorothiazide. In conclusion, telmisartan and nifedipine are both effective in improving insulin signalling in human hypertension; however, telmisartan seems to have broader effects. The combination treatment lercanidipine + enalapril seems to be more effective than lercanidipine + hydrochlorothiazide in activating insulin signalling in human lympho-monocytes.
C1 [De Ciuceis, Carolina; Rossini, Claudia; Porteri, Enzo; Petroboni, Beatrice; La Boria, Elisa; Donini, Carlotta; Rosei, Enrico Agabiti; Rizzoni, Damiano] Univ Brescia, Dept Clin & Expt Sci, Med Clin, I-25121 Brescia, Italy.
   [Flati, Vincenzo; Rufo, Anna; Di Gregorio, Jacopo] Univ Aquila, Dept Biotechnol & Appl Clin Sci, I-67100 Laquila, Italy.
   [Pasini, Evasio] Salvatore Maugeri Fdn, IRCCS, Med Ctr Lumezzane, Brescia, Italy.
C3 University of Brescia; University of L'Aquila; IRCCS Fatebenefratelli;
   Istituti Clinici Scientifici Maugeri IRCCS
RP Rizzoni, D (corresponding author), 2A Med Spedali Civili Brescia, Dept Clin & Expt Sci, Piazza Spedali Civili 1, I-25100 Brescia, Italy.
EM rizzoni@med.unibs.it
RI Di Gregorio, Jacopo/HKW-0312-2023; De Ciuceis, Carolina/AAC-6678-2022;
   FLATI, VINCENZO/R-6231-2018; Pasini, Evasio/AAC-1798-2020
OI FLATI, VINCENZO/0000-0003-1014-297X; Di Gregorio,
   Jacopo/0000-0001-8865-2967; Pasini, Evasio/0000-0003-2836-4490
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NR 35
TC 4
Z9 4
U1 0
U2 2
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
EI 1651-1999
J9 BLOOD PRESSURE
JI Blood Pressure
PD DEC
PY 2014
VL 23
IS 6
BP 330
EP 338
DI 10.3109/08037051.2014.901021
PG 9
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA AT2MD
UT WOS:000344768000002
PM 24786779
OA Bronze
DA 2025-06-11
ER

PT J
AU Paolella, G
   Mandato, C
   Pierri, L
   Poeta, M
   Di Stasi, M
   Vajro, P
AF Paolella, Giulia
   Mandato, Claudia
   Pierri, Luca
   Poeta, Marco
   Di Stasi, Martina
   Vajro, Pietro
TI Gut-liver axis and probiotics: Their role in non-alcoholic fatty liver
   disease
SO WORLD JOURNAL OF GASTROENTEROLOGY
LA English
DT Article
DE Probiotics; Gut-liver axis; Intestinal microbiota; Barrier function;
   Small intestinal bacterial overgrowth; Bacterial translocation;
   Non-alcoholic fatty liver disease
ID INCREASED INTESTINAL PERMEABILITY; RANDOMIZED CLINICAL-TRIAL; TIGHT
   JUNCTION; INSULIN-RESISTANCE; MICROBIOTA COMPOSITION; EPITHELIAL
   BARRIER; HEPATIC STEATOSIS; FECAL MICROBIOTA; OBESE CHILDREN;
   DOUBLE-BLIND
AB The incidence of obesity and its related conditions, including non-alcoholic fatty liver disease (NAFLD), has dramatically increased in all age groups worldwide. Given the health consequences of these conditions, and the subsequent economic burden on healthcare systems, their prevention and treatment have become major priorities. Because standard dietary and lifestyle changes and pathogenically-oriented therapies (e.g., antioxidants, oral hypoglycemic agents, and lipid-lowering agents) often fail due to poor compliance and/or lack of efficacy, novel approaches directed toward other pathomechanisms are needed. Here we present several lines of evidence indicating that, by increasing energy extraction in some dysbiosis conditions or small intestinal bacterial overgrowth, specific gut microbiota and/or a "low bacterial richness" may play a role in obesity, metabolic syndrome, and fatty liver. Under conditions involving a damaged intestinal barrier ("leaky gut"), the gut-liver axis may enhance the natural interactions between intestinal bacteria/bacterial products and hepatic receptors (e.g., toll-like receptors), thus promoting the following cascade of events: oxidative stress, insulin-resistance, hepatic inflammation, and fibrosis. We also discuss the possible modulation of gut microbiota by probiotics, as attempted in NAFLD animal model studies and in several pilot pediatric and adult human studies. Globally, this approach appears to be a promising and innovative add-on therapeutic tool for NAFLD in the context of multi-target therapy. (C) 2014 Baishideng Publishing Group Inc. All rights reserved.
C1 [Paolella, Giulia; Pierri, Luca; Poeta, Marco; Di Stasi, Martina; Vajro, Pietro] Univ Salerno, Dept Med & Surg, I-84081 Salerno, Italy.
   [Mandato, Claudia] Pediat AORN Santobono Pausilipon, I-80123 Naples, Italy.
   [Vajro, Pietro] ELFID European Lab Invest Food Induced Dis, I-80138 Naples, Italy.
C3 University of Salerno
RP Vajro, P (corresponding author), Univ Salerno, Dept Med & Surg, Via Allende, I-84081 Salerno, Italy.
EM pvajro@unisa.it
RI Paolella, Giulia/LSJ-9694-2024; Poeta, Marco/AAL-8522-2020; Di Stasi,
   Martina/ABH-3143-2021; Mandato, Claudia/G-6367-2018; PIERRI,
   LUCA/ADO-2215-2022; Vajro, Pietro/H-5179-2019; Mandato,
   Claudia/B-2760-2018
OI Paolella, Giulia/0009-0006-1312-3941; Pierri, Luca/0000-0002-6096-7497;
   Poeta, Marco/0000-0002-7515-1394; Di Stasi, Martina/0000-0002-5406-6780;
   Mandato, Claudia/0000-0003-2425-5449; VAJRO, PIetro/0000-0002-9418-5880
FU University of Salerno grant
FX Supported by (in part) FARB-ex 60% 2012 of the University of Salerno
   grant to Vajro P
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NR 99
TC 150
Z9 171
U1 1
U2 73
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 8226 REGENCY DR, PLEASANTON, CA 94588 USA
SN 1007-9327
EI 2219-2840
J9 WORLD J GASTROENTERO
JI World J. Gastroenterol.
PD NOV 14
PY 2014
VL 20
IS 42
BP 15518
EP 15531
DI 10.3748/wjg.v20.i42.15518
PG 14
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA AT7KO
UT WOS:000345115400005
PM 25400436
OA Green Published, hybrid, Green Submitted
DA 2025-06-11
ER

PT J
AU Asaoka, Y
   Terai, S
   Sakaida, I
   Nishina, H
AF Asaoka, Yoichi
   Terai, Shuji
   Sakaida, Isao
   Nishina, Hiroshi
TI The expanding role of fish models in understanding non-alcoholic fatty
   liver disease
SO DISEASE MODELS & MECHANISMS
LA English
DT Review
ID MEDAKA ORYZIAS-LATIPES; ZEBRAFISH DANIO-RERIO; ENDOPLASMIC-RETICULUM
   STRESS; DIET-INDUCED OBESITY; HEPATIC STEATOSIS; TRANSGENIC ZEBRAFISH;
   INSULIN-RESISTANCE; ACID-METABOLISM; TERM EXPOSURE; STEATOHEPATITIS
AB Non-alcoholic fatty liver disease (NAFLD) is a condition in which excessive fat accumulates in the liver of an individual who has not consumed excessive alcohol. Non-alcoholic steatohepatitis (NASH), a severe form of NAFLD, can progress to hepatic cirrhosis and/or hepatocellular carcinoma (HCC). NAFLD is considered to be a hepatic manifestation of metabolic syndrome, and its incidence has risen worldwide in lockstep with the increased global prevalence of obesity: Over the last decade, rodent studies have yielded an impressive list of molecules associated with NAFLD and NASH pathogenesis. However, the identification Of currently unknown metabolic factor using Mammalian model Organisms is inefficient and expensive compared with studies using fish models such as zebrafish (Danio rerio) and medaka I (Oryzias latipes): Substantial advances in unraveling the molecular pathogenesis of NAFLD have recently been achieved through unbiased forward genetic screens using small fish models. Furthermore, these easily manipulated organisms have been used to great advantage to evaluate the therapeutic effectiveness of various chemical compounds for the treatment of NAFLD. In this Review, we summarize aspects of NAFLD (specifically focusing on NASH) pathogenesis that have been previously revealed by rodent models, and discuss how small fish are increasingly being used to uncover factors that contribute to normal hepatic lipid metabolism. We describe the various types of fish models in use for this purpose, including those generated by Mutation, transgenesis, or dietary or chemical treatment, and contrast them with rodent models. The use of small fish in identifying novel potential therapeutic agents for the treatment of NAFLD and NASH is also addressed.
C1 [Asaoka, Yoichi; Nishina, Hiroshi] Tokyo Med & Dent Univ, Med Res Inst, Dept Dev & Regenerat Biol, Bunkyo Ku, Tokyo 1138510, Japan.
   [Terai, Shuji; Sakaida, Isao] Yamaguchi Univ, Grad Sch Med, Dept Gastroenterol & Hepatol, Ube, Yamaguchi 7558505, Japan.
C3 Institute of Science Tokyo; Tokyo Medical & Dental University (TMDU);
   Yamaguchi University
RP Nishina, H (corresponding author), Tokyo Med & Dent Univ, Med Res Inst, Dept Dev & Regenerat Biol, Bunkyo Ku, 1-5-45 Yushima, Tokyo 1138510, Japan.
EM nishina.dbio@mri.tmd.ac.jp
OI Terai, Shuji/0000-0002-5439-635X
FU Ministry of Education, Culture, Sports, Science, and Technology of
   Japan; Ministry of Health, Labour, and Welfare of Japan; Joint
   Usage/Research Program of Medical Research Institute, Tokyo Medical and
   Dental University; Grants-in-Aid for Scientific Research [24112509,
   25460358] Funding Source: KAKEN
FX This work was supported by a Grant-in-Aid for Scientific Research on
   Innovative Areas from the Ministry of Education, Culture, Sports,
   Science, and Technology of Japan and the Ministry of Health, Labour, and
   Welfare of Japan. This study was also supported by Joint Usage/Research
   Program of Medical Research Institute, Tokyo Medical and Dental
   University.
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NR 80
TC 93
Z9 102
U1 3
U2 69
PU COMPANY BIOLOGISTS LTD
PI CAMBRIDGE
PA BIDDER BUILDING, STATION RD, HISTON, CAMBRIDGE CB24 9LF, ENGLAND
SN 1754-8403
EI 1754-8411
J9 DIS MODEL MECH
JI Dis. Model. Mech.
PD JUL
PY 2013
VL 6
IS 4
BP 905
EP 914
DI 10.1242/dmm.011981
PG 10
WC Cell Biology; Medicine, Research & Experimental; Pathology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Research & Experimental Medicine; Pathology
GA 188QF
UT WOS:000322207900007
PM 23720231
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Kostapanos, MS
   Florentin, M
   Elisaf, MS
AF Kostapanos, Michael S.
   Florentin, Matilda
   Elisaf, Moses S.
TI Fenofibrate and the kidney: an overview
SO EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
LA English
DT Review
DE Albuminuria; estimated glomerular filtration rate; fenofibrate; kidney;
   renal function; serum creatinine
ID GLOMERULAR-FILTRATION-RATE; CORONARY-HEART-DISEASE; PPAR-ALPHA;
   RENAL-FUNCTION; DIABETIC-NEPHROPATHY; METABOLIC SYNDROME; OXIDATIVE
   STRESS; CYCLOOXYGENASE-2 EXPRESSION; PEROXISOME PROLIFERATORS; INCREASES
   CREATININEMIA
AB Background Fenofibrate has been used for the management of atherogenic dyslipidaemia for many years. Reports of fenofibrate-associated increases in serum creatinine (SCr) levels raised concerns regarding deleterious effects on renal function. Design In this narrative review, we discuss available literature on the effect of fenofibrate on the kidney. Results Most clinical studies showed a rapid (within weeks) raising effect of fenofibrate on SCr levels. This was often accompanied by declined estimated glomerular filtration rate. Risk predictors of this adverse effect might include increased age, impaired renal function and high-dose treatment. Also, the concomitant use of medications affecting renal hemodynamics (e.g. angiotensin-converting enzyme-inhibitors (ACEi) and angiotensin receptor blockers) may predispose to fenofibrate-associated increased SCr levels. Interestingly, SCr increases by fenofibrate were transient and reversible even without treatment discontinuation. Furthermore, fenofibrate was associated with a slower progression of renal function impairment and albuminuria in a long-term basis. Also, fenofibrate might be protective against pathological changes in diabetic nephropathy and hypertensive glomerulosclerosis. In this context, it is uncertain whether fenofibrate-associated increase in SCr levels mirrors true renal function deterioration. Several theories have been expressed. The most dominant one involved the inhibition of renal vasodilatory prostaglandins reducing renal plasma flow and glomerular pressure. Increased creatinine secretion or reduced creatinine clearance by fenofibrate was also suggested. These hypotheses should be settled by further studies. Conclusions Fenofibrate may not be a nephrotoxic drug. However, a close monitoring of SCr levels is relevant especially in high-risk patients. Increases in SCr levels 30% can impose treatment discontinuation.
C1 [Kostapanos, Michael S.; Florentin, Matilda; Elisaf, Moses S.] Univ Ioannina, Sch Med, Dept Internal Med, GR-45110 Ioannina, Greece.
C3 University of Ioannina
RP Elisaf, MS (corresponding author), Univ Ioannina, Sch Med, Dept Internal Med, GR-45110 Ioannina, Greece.
RI Kostapanos, Michalis/AAB-2411-2020
OI Kostapanos, Michalis/0000-0002-7513-5319; ELISAF,
   MOSES/0000-0003-0505-078X
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NR 90
TC 46
Z9 49
U1 0
U2 8
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0014-2972
EI 1365-2362
J9 EUR J CLIN INVEST
JI Eur. J. Clin. Invest.
PD MAY
PY 2013
VL 43
IS 5
BP 522
EP 531
DI 10.1111/eci.12068
PG 10
WC Medicine, General & Internal; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Research & Experimental Medicine
GA 131HK
UT WOS:000317983300011
PM 23480615
DA 2025-06-11
ER

PT J
AU Liu, JL
   Chen, JY
   Chen, CT
   Wang, JH
   Lin, CY
   Chen, PF
   Hung, CH
   Kee, KM
   Lee, CM
   Tsai, LS
   Chen, SC
   Lin, SC
   Lu, SN
AF Liu, Ju-Ling
   Chen, Jing-Yi
   Chen, Chao-Tung
   Wang, Jing-Houng
   Lin, Chih-Yun
   Chen, Pao-Fei
   Hung, Chao-Hung
   Kee, Kwong-Ming
   Lee, Chuan-Mo
   Tsai, Lin-San
   Chen, Shu-Chuan
   Lin, Sheng-Che
   Lu, Sheng-Nan
TI Community-based cross-sectional study: The association of lipids with
   hepatitis C seropositivity and diabetes mellitus
SO JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
LA English
DT Article
DE cholesterol; hepatitis C; hyperlipidemia; triglyceride; type 2 diabetes
   mellitus
ID VIRUS-INFECTION; INSULIN-RESISTANCE; HEPATOCELLULAR-CARCINOMA; B-VIRUS;
   METABOLIC SYNDROME; OXIDATIVE STRESS; LIVER-CIRRHOSIS; RISK-FACTORS;
   PREVALENCE; DISEASE
AB Background and Aims: Hepatitis C virus (HCV) infection is reported to be associated with or to cause type 2 diabetes mellitus (T2DM). Our study aimed to elucidate the role of triglyceride (TG) and cholesterol (CHOL) levels in the association between anti-HCV seropositivity and T2DM in an HCV-endemic area.
   Methods: We analyzed a computerized dataset of 56 338 residents from a community-based comprehensive screening program in Tainan County in southern Taiwan. Fasting glucose, anti-HCV status, hepatitis B surface antigen (HBsAg) status, platelet counts, TG levels, CHOL levels, age, gender, and body mass index were included in the analyses. Multivariate logistic analysis was used to identify factors independently associated with T2DM.
   Results: Older age, being overweight, thrombocytopenia, hypertriglyceridemia, hypercholesterolemia, anti-HCV seropositivity, and HBsAg seronegativity were common factors independently associated with diabetes. Among all models of multiple logistic regression analysis used for identifying factors independently associated with T2DM, anti-HCV seropositivity was only identified in the models that included either hypertriglyceridemia or hypercholesterolemia. When subjects were divided into hyperlipidemia (CHOL, > 200 or TG, > 150 mg/dL; n = 33 393) or non-hyperlipidemia subgroups (CHOL, < 200 and TG, < 150 mg/dL; n = 22 945), anti-HCV seropositivity was identified as an independent factor only in the non-hyperlipidemia subgroup. The odds ratio was 1.35, with a 95% confidence interval of 1.171.55.
   Conclusions: This study demonstrates that the lipid level is associated with the relationship between T2DM and anti-HCV seropositivity in non-hyperlipidemic individuals. However, the relationship between HCV and T2DM did not exist when the lipid level was not included in the analysis.
C1 [Wang, Jing-Houng; Lin, Chih-Yun; Chen, Pao-Fei; Hung, Chao-Hung; Kee, Kwong-Ming; Lee, Chuan-Mo; Lu, Sheng-Nan] Kaohsiung Chang Gung Mem Hosp, Dept Internal Med, Div Hepatogastroenterol, Kaohsiung 833, Taiwan.
   [Chen, Chao-Tung; Wang, Jing-Houng; Lin, Chih-Yun; Chen, Pao-Fei; Hung, Chao-Hung; Kee, Kwong-Ming; Lee, Chuan-Mo; Lu, Sheng-Nan] Chang Gung Univ, Coll Med, Kaohsiung, Taiwan.
   [Liu, Ju-Ling] Tajen Univ, Coll Pharm & Hlth Care, Dept Nursing, Yenpu, Pingtung, Taiwan.
   [Chen, Jing-Yi] St Joseph Hosp, Dept Family Med, Kaohsiung, Taiwan.
   [Chen, Chao-Tung] Kaohsiung Chang Gung Mem Hosp, Dept Family Med, Kaohsiung 833, Taiwan.
   [Tsai, Lin-San; Chen, Shu-Chuan; Lin, Sheng-Che] Tainan City Govt, Dept Hlth, Tainan, Taiwan.
C3 Chang Gung Memorial Hospital; Chang Gung University; Chang Gung Memorial
   Hospital
RP Lu, SN (corresponding author), Kaohsiung Chang Gung Mem Hosp, Dept Internal Med, Div Hepatogastroenterol, 123 Ta Pei Rd, Kaohsiung 833, Taiwan.
EM juten@ms17.hinet.net
FU Grant of Bureau of Health Promotion, Department of Health, R.O.C.
   (Taiwan) [DOH99-HP1502]
FX This study was supported by the Grant of Bureau of Health Promotion,
   Department of Health, R.O.C. (Taiwan) (DOH99-HP1502) to Dr Sheng-Nan Lu.
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NR 46
TC 8
Z9 9
U1 0
U2 0
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0815-9319
J9 J GASTROEN HEPATOL
JI J. Gastroenterol. Hepatol.
PD NOV
PY 2012
VL 27
IS 11
BP 1688
EP 1694
DI 10.1111/j.1440-1746.2012.07212.x
PG 7
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 030FC
UT WOS:000310554000009
PM 22742891
DA 2025-06-11
ER

PT J
AU Mastrodonato, M
   Portincasa, P
   Mentino, D
   Rossi, R
   Resta, L
   Ferri, D
   Liquori, GE
AF Mastrodonato, Maria
   Portincasa, Piero
   Mentino, Donatella
   Rossi, Roberta
   Resta, Leonardo
   Ferri, Domenico
   Liquori, Giuseppa Esterina
TI Caveolin-1 and mitochondrial alterations in regenerating rat liver
SO MICROSCOPY RESEARCH AND TECHNIQUE
LA English
DT Article
DE liver steatosis; metabolic syndrome; oxydative stress; caveolin-1;
   mitochondria
ID ULTRASTRUCTURE; HEPATOCYTES; HEPATECTOMY; EXPRESSION; STEATOSIS;
   PROTEINS; GROWTH; CANCER; MODEL; CELL
AB The liver has a remarkable ability to regenerate after partial hepatectomy (PH), although the factors governing such ability are still poorly understood. During the prereplicative phase of the regeneration, ultrastructural alterations of periportal hepatocytes were seen, including mitochondrial swelling, abnormal accumulation of lipids, and myelin figures which could lead to the formation of lipid droplets. As it has been hypothesized that caveolin-1 is involved in lipidogenesis and in mitochondrial homeostasis, we aimed to study the subcellular distribution of caveolin-1 in hepatocytes at an early stage following PH. Liver samples were processed for light and electron microscopy at 0 h, 24 h, and 96 h after PH. The expression and subcellular distribution of caveolin-1 was assessed by immunohistochemical and immunocytochemical techniques. Following PH, at 24 h, membranes of altered mitochondria of periportal hepatocytes exhibited significant decrease of caveolin-1 expression compared with control. Myelin figures showing high expression of caveolin-1 were also seen. At 96 h, hepatocytes became ultrastructurally similar to the control liver, and the expression of caveolin-1 on mitochondria showed a moderate increase compared with 24 h after PH. Decrease of expression of caveolin-1 in the altered liver mitochondrial membranes at 24 h following PH, and the high expression of caveolin-1 observed on myelin figures, suggests involvement of caveolin-1 is in both mitochondrial homeostasis and lipidogenesis. Addressing the role played by caveolin-1 during liver regeneration might disclose additional features of mitochondrial homeostasis and lipidogenesis during frequent metabolic liver diseases. Microsc. Res. Tech. 75:10261032, 2012. (c) 2012 Wiley Periodicals, Inc.
C1 [Mastrodonato, Maria; Mentino, Donatella; Ferri, Domenico; Liquori, Giuseppa Esterina] Aldo Moro Univ, Dept Biol, I-70125 Bari, Italy.
   [Portincasa, Piero] Aldo Moro Univ, Dept Internal Med, I-70125 Bari, Italy.
   [Rossi, Roberta; Resta, Leonardo] Aldo Moro Univ, Dept Pathol Anat, Lab Ultrastruct Pathol, I-70125 Bari, Italy.
C3 Universita degli Studi di Bari Aldo Moro; Universita degli Studi di Bari
   Aldo Moro; Universita degli Studi di Bari Aldo Moro
RP Mastrodonato, M (corresponding author), Aldo Moro Univ, Dept Biol, Via Orabona 4, I-70125 Bari, Italy.
EM m.mastrodonato@biologia.uniba.it
RI portincasa, piero/J-7245-2018; Rossi, Roberta/J-9137-2016; Mastrodonato,
   Maria/P-4513-2016
OI portincasa, piero/0000-0001-5359-1471; ROSSI,
   Roberta/0000-0003-4586-9044; Mentino, Donatella/0000-0002-0680-5251;
   Mastrodonato, Maria/0000-0002-0799-8032; Resta,
   Leonardo/0000-0003-4335-4776
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NR 26
TC 10
Z9 11
U1 0
U2 7
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1059-910X
J9 MICROSC RES TECHNIQ
JI Microsc. Res. Tech.
PD AUG
PY 2012
VL 75
IS 8
BP 1026
EP 1032
DI 10.1002/jemt.22027
PG 7
WC Anatomy & Morphology; Biology; Microscopy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Anatomy & Morphology; Life Sciences & Biomedicine - Other Topics;
   Microscopy
GA 979AH
UT WOS:000306786500004
PM 22431231
DA 2025-06-11
ER

PT J
AU Oliveira, LPM
   de Jesús, RP
   Freire, TO
   Oliveira, CP
   Lyra, AC
   Lyra, LGC
AF Oliveira, L. P. M.
   de Jesus, R. P.
   Freire, T. O.
   Oliveira, C. P.
   Castro Lyra, A.
   Lyra, L. G. C.
TI Possible molecular mechanisms soy-mediated in preventing and treating
   nonalcoholic fatty liver disease
SO NUTRICION HOSPITALARIA
LA English
DT Review
DE Soy; Protein; Dietary supplements; NAFLD; Stealosis
ID CHRONIC HEPATITIS-C; METABOLIC SYNDROME; INSULIN-RESISTANCE;
   MESSENGER-RNA; ADVANCED FIBROSIS; OXIDATIVE STRESS; ACID OXIDATION;
   OBESE-PATIENTS; FOLLOW-UP; PROTEIN
AB The aim of this review is to describe the molecular mechanisms of nonalcoholic fatty liver disease (NAFLD) and to present evidence regarding the mechanisms of soy-mediated therapeutic activity in preventing and treating NAFLD. NAFLD is induced by multiple metabolic pathways, including an increase in the release of fatty acids from the adipose tissue (lipolysis), insulin resistance (IR), and an increase in "de novo" fatty acid synthesis. Furthermore, NAFLD is correlated with a decrease in liver beta-oxidation, an increase in oxygen free radical production, and an increase in pro-inflammatory cytokine production, which leads to an increase in liver fat and, subsequently, to tissue damage.
   The bioactive compounds in soy can prevent and treat NAFLD by modulating lipid metabolism and regulating the expression of related transcription factors. Soy intake decreases the expression of sterol regulatory-element binding protein-1c (SREBP-1) and increases the expression of SREBP-2, which are transcription factors associated with the regulation of hepatic lipogenesis and reduction of cholesterol synthesis and absorption in the liver, respectively. Besides, interactions between soy components, such as standard amino acids, polyunsaturated fat, and the isoflavonoid-enriched fraction, are believed to improve fatty acid oxidation in the liver parenchyma by increasing the expression of peroxisome proliferator-activated receptor alpha (PPAR alpha)-regulated genes, thus decreasing lipid accumulation in the liver. Therefore, including soy-derived foods in the diet as a therapeutic tool for patients with NAFLD might improve their clinical evolution. (Nutr Hosp. 2012;27:991-998) DOI: 10.3305/nh.2012.27.4.5833
C1 [Oliveira, L. P. M.] Univ Fed Bahia, Escola Nutr, Dept Ciencia Nutr, BR-40110150 Salvador, BA, Brazil.
   [Oliveira, C. P.] Univ Sao Paulo, Sch Med, Dept Gastroenterol LIM 07, Sao Paulo, Brazil.
   [Castro Lyra, A.] Univ Fed Bahia, Dept Med, Div Gastroenterol & Hepatol, BR-40110150 Salvador, BA, Brazil.
   [Lyra, L. G. C.] Sao Rafael Hosp, Salvador, BA, Brazil.
C3 Universidade Federal da Bahia; Universidade de Sao Paulo; Universidade
   Federal da Bahia
RP Oliveira, LPM (corresponding author), Univ Fed Bahia, Escola Nutr, Dept Ciencia Nutr, Ave Araujo Pinho,32 Canela, BR-40110150 Salvador, BA, Brazil.
EM lucipmo@ufba.br
RI Oliveira, Claudia/D-1216-2014
OI P Oliveira, Claudia/0000-0002-2848-417X
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NR 57
TC 18
Z9 19
U1 0
U2 19
PU AULA MEDICA EDICIONES
PI MADRID
PA C/ISABEL COLBRAND, 10-12 NAVE 78 S PLANTA CIUDAD INDUSTRIAL
   VENECIA-EDIFICIO ALFA, MADRID, 28050, SPAIN
SN 0212-1611
EI 1699-5198
J9 NUTR HOSP
JI Nutr. Hosp.
PD JUL-AUG
PY 2012
VL 27
IS 4
BP 991
EP 998
DI 10.3305/nh.2012.27.4.5833
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 982KP
UT WOS:000307042300005
PM 23165534
DA 2025-06-11
ER

PT J
AU Miyamoto, T
   Qureshi, AR
   Heimbürger, O
   Bárány, P
   Carrero, K
   Sjöberg, B
   Lindholm, B
   Stenvinkel, P
   Carrero, JJ
AF Miyamoto, Tetsu
   Qureshi, Abdul Rashid
   Heimburger, Olof
   Barany, Peter
   Carrero, Karin
   Sjoberg, Bodil
   Lindholm, Bengt
   Stenvinkel, Peter
   Carrero, Juan Jesus
TI Inverse Relationship between the Inflammatory Marker Pentraxin-3, Fat
   Body Mass, and Abdominal Obesity in End-Stage Renal Disease
SO CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
LA English
DT Article
ID CHRONIC KIDNEY-DISEASE; C-REACTIVE PROTEIN; OXIDATIVE STRESS; INNATE
   IMMUNITY; CARDIOVASCULAR-DISEASE; HEMODIALYSIS-PATIENTS; METABOLIC
   SYNDROME; LONG PENTRAXIN-3; ADIPOSE-TISSUE; RISK-FACTORS
AB Background and objectives Pentraxin-3 (PTX3) belongs to the same pentraxin superfamily of acute-phase reactants as (C-reactive protein (CRP). Abdominal fat accumulation in ESRD is considered a chronic inflammatory state, but the relationship of PTX3 to this phenomenon is unknown. This study assesses plausible associations between PTX3 and surrogates of fat mass deposits in dialysis patients.
   Design, setting, participants, & measurements Circulating levels of PTX3, CRP, and IL-6 were cross-sectionally analyzed in relation to anthropometric and nutritional surrogate markers of fat tissue in two cohorts comprising 156 prevalent hemodialysis (HD) and 216 incident dialysis patients.
   Results In both cohorts, PTX3 was negatively associated with body mass index (BMI) and fat body mass index (FBMI) derived from anthropometrics and leptin, whereas there was a positive association with adiponectin. In prevalent HD patients, those with larger waist circumference (above gender-specific median values) had lower PTX3, higher CRP, and higher IL-6 levels. This was also true in multivariate analyses. In both cohorts, multivariate regression analyses showed that PTX3 was negatively and CRP (or IL-6) was positively associated with FBMI.
   Conclusions Although CRP and IL-6 were directly associated with body fat, PTX3 levels showed negative correlations with surrogates of adipose tissue in two independent cohorts of ESRD patients. Understanding the underlying reasons behind these opposite associations may have clinical relevance given the survival advantage described for obese patients on dialysis. Clin J Am Soc Nephrol 6: 2785-2791, 2011. doi: 10.2215/CJN.02320311
C1 [Carrero, Juan Jesus] Karolinska Inst, Div Renal Med, Karolinska Univ Hosp Huddinge K56, Dept Clin Sci Intervent & Technol, S-14186 Stockholm, Sweden.
   [Miyamoto, Tetsu; Qureshi, Abdul Rashid; Heimburger, Olof; Barany, Peter; Carrero, Karin; Sjoberg, Bodil; Lindholm, Bengt; Stenvinkel, Peter; Carrero, Juan Jesus] Karolinska Inst, Div Baxter Novum, Dept Clin Sci Intervent & Technol, S-14186 Stockholm, Sweden.
   [Carrero, Juan Jesus] Karolinska Inst, Ctr Mol Med, S-14186 Stockholm, Sweden.
   [Carrero, Juan Jesus] Karolinska Inst, Ctr Gender Med, S-14186 Stockholm, Sweden.
   [Miyamoto, Tetsu] Univ Occupat & Environm Hlth, Sch Med, Dept Internal Med 2, Kitakyushu, Fukuoka 807, Japan.
C3 Karolinska Institutet; Karolinska University Hospital; Karolinska
   Institutet; Karolinska Institutet; Karolinska Institutet; University of
   Occupational & Environmental Health - Japan
RP Carrero, JJ (corresponding author), Karolinska Inst, Div Renal Med, Karolinska Univ Hosp Huddinge K56, Dept Clin Sci Intervent & Technol, S-14186 Stockholm, Sweden.
EM juan.jesus.carrero@ki.se
RI Barany, Peter/I-6116-2019; Miyamoto, Tetsu/HJA-9542-2022; Lindholm,
   Bengt/P-1334-2017; Qureshi, Abdul Rashid Tony/G-1358-2010
OI Stenvinkel, Peter/0000-0002-8785-4820; Carrero, Juan
   Jesus/0000-0003-4763-2024; Lindholm, Bengt/0000-0003-4269-4293;
   Heimburger, Olof/0000-0003-0901-4145; Barany, Peter/0000-0001-6501-8293;
   Qureshi, Abdul Rashid Tony/0000-0003-0536-5327
FU Amgen; Osterman and Westman Foundations; Swedish Medical Research
   Council; Baxter Healthcare Corporation
FX We thank the patients and participants in this study. We are indebted to
   our research staff at KBC (Annika Nilsson, Ann-Christin Emmoth, and
   (Ulrika Jensen) and the KFC (Bjorn Anderstam, Monica Eriksson, and
   Ann-Christin Bragfors-Helin). The collection of the prevalent HD patient
   material was supported by an unrestricted grant from Amgen. We further
   acknowledge the support from the Osterman and Westman Foundations as
   well as the Swedish Medical Research Council. Baxter Novum is the result
   of a grant to the Karolinska Institute from Baxter Healthcare
   Corporation.
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NR 38
TC 49
Z9 52
U1 0
U2 3
PU AMER SOC NEPHROLOGY
PI WASHINGTON
PA 1725 I ST, NW STE 510, WASHINGTON, DC 20006 USA
SN 1555-9041
EI 1555-905X
J9 CLIN J AM SOC NEPHRO
JI Clin. J. Am. Soc. Nephrol.
PD DEC
PY 2011
VL 6
IS 12
BP 2785
EP 2791
DI 10.2215/CJN.02320311
PG 7
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 860LD
UT WOS:000297948900010
PM 22157708
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU O'Rourke, RW
   White, AE
   Metcalf, MD
   Olivas, AS
   Mitra, P
   Larison, WG
   Cheang, EC
   Varlamov, O
   Corless, CL
   Roberts, CT
   Marks, DL
AF O'Rourke, R. W.
   White, A. E.
   Metcalf, M. D.
   Olivas, A. S.
   Mitra, P.
   Larison, W. G.
   Cheang, E. C.
   Varlamov, O.
   Corless, C. L.
   Roberts, C. T., Jr.
   Marks, D. L.
TI Hypoxia-induced inflammatory cytokine secretion in human adipose tissue
   stromovascular cells
SO DIABETOLOGIA
LA English
DT Article
DE Adipose tissue; Hypoxia; Inflammation; JNK; acrophage; Obesity; p38; T
   cell
ID NECROSIS-FACTOR-ALPHA; PROTEIN-KINASE PLAYS; INSULIN-RESISTANCE; HUMAN
   ADIPOCYTES; OBESE SUBJECTS; MACROPHAGE INFILTRATION; GENE-EXPRESSION;
   TNF-ALPHA; METABOLIC SYNDROME; ENDOTHELIAL-CELLS
AB Hypoxia has been implicated as a cause of adipose tissue inflammation in obesity, although the inflammatory response of human adipose tissue to hypoxia is not well understood. The goal of this study was to define in vitro inflammatory responses of human adipose tissue to hypoxia and identify molecular mechanisms of hypoxia-induced inflammation.
   The inflammatory milieu and responses of visceral (VAT) and subcutaneous (SAT) adipose tissue explants and purified stromovascular cells (SVFs) from obese and lean humans were studied in an in vitro hypoxic culture system using quantitative real-time PCR, ELISA, western blotting, immunofluorescence microscopy, flow cytometry and immunohistochemistry.
   Human adipose tissue in obesity demonstrates an increased leucocyte infiltrate that is greater in VAT than SAT and involves macrophages, T cells and natural killer (NK) cells. Hypoxic culture regulates inflammatory cytokine secretion and transcription of metabolic stress response genes in human adipose tissue SVF. Adipocyte diameter is increased and adipose tissue capillary density is decreased in obese participants. Inhibition of c-Jun terminal kinase (JNK) or p38 significantly attenuates hypoxia-induced SVF inflammatory responses. Hypoxia induces phosphorylation of p38 in adipose tissue.
   Human adipose tissue in obesity is characterised by a depot-specific inflammatory cell infiltrate that involves not only macrophages, but also T cells and NK cells. Hypoxia induces inflammatory cytokine secretion by human adipose tissue SVF, the primary source of which is adipose tissue macrophages. These data implicate p38 in the regulation of hypoxia-induced inflammation and suggest that alterations in adipocyte diameter and adipose tissue capillary density may be potential underlying causes of adipose tissue hypoxia.
C1 [O'Rourke, R. W.; White, A. E.; Metcalf, M. D.; Olivas, A. S.; Mitra, P.] Oregon Hlth & Sci Univ, Dept Surg, Portland, OR 97201 USA.
   [Mitra, P.; Roberts, C. T., Jr.; Marks, D. L.] Oregon Hlth & Sci Univ, Dept Pediat, Portland, OR 97201 USA.
   [Roberts, C. T., Jr.] Oregon Hlth & Sci Univ, Dept Med, Portland, OR 97201 USA.
   [Corless, C. L.] Oregon Hlth & Sci Univ, Dept Pathol, Portland, OR 97201 USA.
   [Larison, W. G.; Cheang, E. C.] Oregon Hlth & Sci Univ, Sch Med, Portland, OR 97201 USA.
   [Varlamov, O.; Roberts, C. T., Jr.] Natl Primate Res Ctr, Beaverton, OR USA.
C3 Oregon Health & Science University; Oregon Health & Science University;
   Oregon Health & Science University; Oregon Health & Science University;
   Oregon Health & Science University; Oregon Health & Science University;
   Oregon National Primate Research Center
RP O'Rourke, RW (corresponding author), Oregon Hlth & Sci Univ, Dept Surg, 3181 SW Sam Jackson Pk Rd,L223A, Portland, OR 97201 USA.
EM orourkro@ohsu.edu
RI Varlamov, Oleg/AAK-6980-2020; Roberts, Charles/K-6953-2017
OI O'Rourke, Robert/0000-0002-4038-4198; Roberts,
   Charles/0000-0003-1756-5772
FU National Institutes of Health [K08DK074397, R01DK070333, P51R000153];
   American Surgical Association Foundation; Oregon Clinical and
   Translational Research Institute; National Center for Research Resources
   [UL1 RR024140]; NIH
FX This work was supported by National Institutes of Health Grants
   K08DK074397 (R. W. O'Rourke), R01DK070333 (D. L. Marks) and P51R000153
   (C. T. Roberts), an American Surgical Association Foundation Fellowship
   Award (R. W. O'Rourke), an Oregon Clinical and Translational Research
   Institute Summer Research Award, grant number UL1 RR024140 from the
   National Center for Research Resources, and NIH Roadmap for Medical
   Research (E. C. Cheang). We thank C. Gendron and C. Poage for expert
   technical assistance with immunohistochemistry.
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NR 49
TC 121
Z9 146
U1 0
U2 19
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0012-186X
J9 DIABETOLOGIA
JI Diabetologia
PD JUN
PY 2011
VL 54
IS 6
BP 1480
EP 1490
DI 10.1007/s00125-011-2103-y
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 760ML
UT WOS:000290328300026
PM 21400042
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU O'Neill, ED
   Wilding, JPH
   Kahn, CR
   Van Remmen, H
   McArdle, A
   Jackson, MJ
   Close, GL
AF O'Neill, Elaine D.
   Wilding, John P. H.
   Kahn, C. Ronald
   Van Remmen, Holly
   McArdle, Anne
   Jackson, Malcolm J.
   Close, Graeme L.
TI Absence of insulin signalling in skeletal muscle is associated with
   reduced muscle mass and function: evidence for decreased protein
   synthesis and not increased degradation
SO AGE
LA English
DT Article
DE Ageing; ROS; Muscle
ID OXIDATIVE STRESS; METABOLIC SYNDROME; MECHANISMS; RESISTANCE; EXERCISE;
   MICE; AUTOPHAGY; ATROPHY; ADULT
AB Loss of skeletal muscle mass and function is observed in many insulin-resistant disease states such as diabetes, cancer cachexia, renal failure and ageing although the mechanisms for this remain unclear. We hypothesised that impaired insulin signalling results in reduced muscle mass and function and that this decrease in muscle mass and function is due to both increased production of atrogenes and aberrant reactive oxygen species (ROS) generation. Maximum tetanic force of the extensor digitorum longus of muscle insulin receptor knockout (MIRKO) and lox/lox control mice was measured in situ. Muscles were removed for the measurement of mass, histological examination and ROS production. Activation of insulin signalling pathways, markers of muscle atrophy and indices of protein synthesis were determined in a separate group of MIRKO and lox/lox mice 15 min following treatment with insulin. Muscles from MIRKO mice had 36% lower maximum tetanic force generation compared with muscles of lox/lox mice. Muscle fibres of MIRKO mice were significantly smaller than those of lox/lox mice with no apparent structural abnormalities. Muscles from MIRKO mice demonstrated absent phosphorylation of AKT in response to exogenous insulin along with a failure to phosphorylate ribosomal S6 compared with lox/lox mice. Atrogin-1 and MuRF1 relative mRNA expression in muscles from MIRKO mice were decreased compared with muscles from lox/lox mice following insulin treatment. There were no differences in markers of reactive oxygen species damage between muscles from MIRKO mice and lox/lox mice. These data support the hypothesis that the absence of insulin signalling contributes to reduced muscle mass and function though decreased protein synthesis rather than proteasomal atrophic pathways.
C1 [O'Neill, Elaine D.; Wilding, John P. H.; McArdle, Anne; Jackson, Malcolm J.] Univ Liverpool, Sch Clin Sci, Liverpool L69 3GA, Merseyside, England.
   [Kahn, C. Ronald] Harvard Univ, Sch Med, Dept Med, Joslin Diabet Ctr, Boston, MA 02215 USA.
   [Van Remmen, Holly] Univ Texas Hlth Sci Ctr San Antonio, Barshop Inst Longev & Aging Studies, San Antonio, TX 78229 USA.
C3 University of Liverpool; Harvard University; Harvard Medical School;
   Harvard University Medical Affiliates; Joslin Diabetes Center, Inc.;
   University of Texas System; University of Texas Health Science Center at
   San Antonio
RP Close, GL (corresponding author), Liverpool John Moores Univ, Res Inst Sport & Exercise Sci, Liverpool L3 2ET, Merseyside, England.
EM g.l.close@ljmu.ac.uk
RI Kahn, Ronald/AAY-2435-2021; Wilding, John/ABB-6443-2020; Close,
   graeme/I-7287-2012; Wilding, John/A-7106-2008
OI Jackson, Malcolm/0000-0003-3683-8297; Close, Graeme/0000-0002-7210-9553;
   Wilding, John/0000-0003-2839-8404
FU Nathan Shock Center for Excellence in Basic Biology of Aging [AG 13319];
   MRC [G0700919] Funding Source: UKRI
FX The authors would like to thank Dr. Anna Kayani and Dr. Lea Zibrik from
   the Pathophysiology group at The University of Liverpool for their
   assistance with the PCR, Dr. Daniel Cuthbertson for his assistance in
   the preparation of the manuscript, Research into Ageing for their
   continued financial support and the Oxidative Stress Core of the Nathan
   Shock Center for Excellence in Basic Biology of Aging, Grant, AG 13319
   (HVR).
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NR 42
TC 32
Z9 36
U1 0
U2 11
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0161-9152
EI 1574-4647
J9 AGE
JI Age
PD JUN
PY 2010
VL 32
IS 2
BP 209
EP 222
DI 10.1007/s11357-009-9125-0
PG 14
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA 590BL
UT WOS:000277198300008
PM 20431988
OA Green Published
DA 2025-06-11
ER

PT J
AU Xun, PC
   Liu, K
   Morris, JS
   Daviglus, ML
   Stevens, J
   Jacobs, DR
   He, K
AF Xun, Pengcheng
   Liu, Kiang
   Morris, J. Steven
   Daviglus, Martha L.
   Stevens, June
   Jacobs, David R., Jr.
   He, Ka
TI Associations of Toenail Selenium Levels With Inflammatory Biomarkers of
   Fibrinogen, High-Sensitivity C-Reactive Protein, and Interleukin-6
SO AMERICAN JOURNAL OF EPIDEMIOLOGY
LA English
DT Article
DE C-reactive protein; fibrinogen; inflammation; interleukin-6; nails;
   selenium
ID ARTERY RISK DEVELOPMENT; YOUNG-ADULTS CARDIA; PLASMA-FIBRINOGEN;
   METABOLIC SYNDROME; DIABETES-MELLITUS; OXIDANT STRESS; VITAMIN-E;
   CORONARY; ANTIOXIDANTS; MORTALITY
AB The authors examined the associations of toenail selenium levels with blood concentrations of fibrinogen, high-sensitivity C-reactive protein (hs-CRP), and interleukin-6 (IL-6) in an 18-year follow-up study comprising 4,032 Americans aged 20-32 years at baseline (1987) from the Coronary Artery Risk Development in Young Adults (CARDIA) Trace Element Study. Toenail samples were collected in 1987, and selenium concentrations were measured by means of instrumental neutron-activation analysis. Fibrinogen level was analyzed in 1990, 1992, and 2005; hs-CRP was assessed in 1992, 2000, and 2005; and IL-6 was measured in 2005. After adjustment for potential confounders, no statistically significant associations between toenail selenium levels and any of the 3 inflammatory biomarkers were documented. Comparing the highest quintile of toenail selenium level with the lowest, odds ratios for elevated levels of fibrinogen (> 460 mg/mL), hs-CRP (> 3 mu g/mL), and IL-6 (> 3.395 pg/mL, 80th percentile) were 1.03 (95% confidence interval (CI): 0.77, 1.38; P for trend = 0.76), 1.02 (95% CI: 0.83, 1.27; P for trend = 0.92), and 0.98 (95% CI: 0.71, 1.36; P for trend = 0.82), respectively. Gender, race/ethnicity, smoking status, and selenium supplementation did not appreciably modify these results. This study found no associations between toenail selenium and inflammation as measured by fibrinogen, hs-CRP, and IL-6.
C1 [Xun, Pengcheng; Stevens, June; He, Ka] Univ N Carolina, Dept Nutr, Gillings Sch Global Publ Hlth, Chapel Hill, NC 27599 USA.
   [Xun, Pengcheng; Stevens, June; He, Ka] Univ N Carolina, Sch Med, Chapel Hill, NC 27599 USA.
   [Xun, Pengcheng; Stevens, June; He, Ka] Univ N Carolina, Dept Epidemiol, Gillings Sch Global Publ Hlth, Chapel Hill, NC 27599 USA.
   [Liu, Kiang; Daviglus, Martha L.] Northwestern Univ, Dept Prevent Med, Feinberg Sch Med, Chicago, IL 60611 USA.
   [Morris, J. Steven] Univ Missouri, Res Reactor Ctr, Columbia, MO USA.
   [Jacobs, David R., Jr.] Univ Minnesota, Dept Epidemiol, Sch Publ Hlth, Minneapolis, MN USA.
C3 University of North Carolina; University of North Carolina Chapel Hill;
   University of North Carolina; University of North Carolina Chapel Hill;
   University of North Carolina School of Medicine; University of North
   Carolina; University of North Carolina Chapel Hill; Northwestern
   University; Feinberg School of Medicine; University of Missouri System;
   University of Missouri Columbia; University of Minnesota System;
   University of Minnesota Twin Cities
RP He, K (corresponding author), Univ N Carolina, Dept Nutr, Gillings Sch Global Publ Hlth, 2221 McGavran Greenberg Hall,Campus Box 7461, Chapel Hill, NC 27599 USA.
EM kahe@unc.edu
RI pengcheng, xun/D-3411-2013; Jacobs, David/G-5405-2011
OI Jacobs, David/0000-0002-7232-0543; Xun, Pengcheng/0000-0002-6245-4505
FU National Institutes of Health [R01HL081572, N01-HC-48047, N01-HC-48048,
   N01-HC-48049, N01-HC-48050, N01-HC-95095]
FX This study was support by National Institutes of Health grants
   R01HL081572, N01-HC-48047, N01-HC-48048, N01-HC-48049, N01-HC-48050, and
   N01-HC-95095.
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NR 44
TC 20
Z9 22
U1 0
U2 3
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0002-9262
EI 1476-6256
J9 AM J EPIDEMIOL
JI Am. J. Epidemiol.
PD APR 1
PY 2010
VL 171
IS 7
BP 793
EP 800
DI 10.1093/aje/kwq001
PG 8
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA 578IL
UT WOS:000276286800005
PM 20219762
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Chen, FL
   Sarver, DC
   Saqib, M
   Velez, LM
   Aja, S
   Seldin, MM
   Wong, GW
AF Chen, Fangluo
   Sarver, Dylan C.
   Saqib, Muzna
   Velez, Leandro M.
   Aja, Susan
   Seldin, Marcus M.
   Wong, G. William
TI Loss of CTRP10 results in female obesity with preserved metabolic health
SO ELIFE
LA English
DT Article
DE obesity; diabetes; metabolically healthy obese; Metabolism; insulin
   resistance
ID REV-ERB-ALPHA; IMPROVES INSULIN SENSITIVITY; ADIPOSE-TISSUE
   INFLAMMATION; C1Q/TNF-RELATED PROTEIN 6; COUPLED RECEPTOR BAI3; HEPATIC
   STEATOSIS; FOOD-INTAKE; ISCHEMIA-REPERFUSION; MYOCARDIAL INJURY;
   SKELETAL-MUSCLE
AB Obesity is a major risk factor for type 2 diabetes, dyslipidemia, cardiovascular disease, and hypertension. Intriguingly, there is a subset of metabolically healthy obese (MHO) individuals who are seemingly able to maintain a healthy metabolic profile free of metabolic syndrome. The molecular underpinnings of MHO, however, are not well understood. Here, we report that CTRP10/C1QL2-deficient mice represent a unique female model of MHO. CTRP10 modulates weight gain in a striking and sexually dimorphic manner. Female, but not male, mice lacking CTRP10 develop obesity with age on a low-fat diet while maintaining an otherwise healthy metabolic profile. When fed an obesogenic diet, female Ctrp10 knockout (KO) mice show rapid weight gain. Despite pronounced obesity, Ctrp10 KO female mice do not develop steatosis, dyslipidemia, glucose intolerance, insulin resistance, oxidative stress, or low-grade inflammation. Obesity is largely uncoupled from metabolic dysregulation in female KO mice. Multi-tissue transcriptomic analyses highlighted gene expression changes and pathways associated with insulin-sensitive obesity. Transcriptional correlation of the differentially expressed gene (DEG) orthologs in humans also shows sex differences in gene connectivity within and across metabolic tissues, underscoring the conserved sex-dependent function of CTRP10. Collectively, our findings suggest that CTRP10 negatively regulates body weight in females, and that loss of CTRP10 results in benign obesity with largely preserved insulin sensitivity and metabolic health. This female MHO mouse model is valuable for understanding sex-biased mechanisms that uncouple obesity from metabolic dysfunction.
C1 [Chen, Fangluo; Sarver, Dylan C.; Saqib, Muzna; Wong, G. William] Johns Hopkins Univ, Sch Med, Dept Physiol, Baltimore, MD 21218 USA.
   [Chen, Fangluo; Sarver, Dylan C.; Saqib, Muzna; Aja, Susan; Wong, G. William] Johns Hopkins Univ, Ctr Metab & Obes Res, Sch Med, Baltimore, MD 21218 USA.
   [Velez, Leandro M.; Seldin, Marcus M.] Univ Calif Irvine, Ctr Epigenet & Metab, Irvine, CA USA.
   [Velez, Leandro M.; Seldin, Marcus M.] Univ Calif Irvine, Dept Biol Chem, Irvine, CA USA.
   [Aja, Susan] Johns Hopkins Univ, Sch Med, Dept Neurosci, Baltimore, MD USA.
C3 Johns Hopkins University; Johns Hopkins University; University of
   California System; University of California Irvine; University of
   California System; University of California Irvine; Johns Hopkins
   University
RP Wong, GW (corresponding author), Johns Hopkins Univ, Sch Med, Dept Physiol, Baltimore, MD 21218 USA.; Wong, GW (corresponding author), Johns Hopkins Univ, Ctr Metab & Obes Res, Sch Med, Baltimore, MD 21218 USA.
EM gwwong@jhmi.edu
RI Velez, Leandro/V-8791-2019
FU National Institute of Diabetes and Digestive and Kidney Diseases
   [DK084171, HL138193, DK130640]; National Institutes of Health [HL007534,
   1U2CDK135066-01, DK020572]; NIH T32 training grant [DK114356,
   UM1HG006348]; NIH
FX This work was supported by the National Institutes of Health (DK084171
   to GWW, HL138193 and DK130640 to MMS). DCS is supported by an NIH T32
   training grant (HL007534). The fecal bomb calorimetry analysis was
   performed at the University of Michigan Animal Phenotyping Core,
   supported by center grants 1U2CDK135066-01 (Mi-MPMOD) and DK020572
   (MDRC). The FPLC/serum analyses were performed at the Mouse Metabolism
   and Phenotyping Core (MMPC) at the Baylor College of Medicine, supported
   by NIH grants (DK114356 and UM1HG006348).
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NR 142
TC 0
Z9 0
U1 1
U2 1
PU eLIFE SCIENCES PUBL LTD
PI CAMBRIDGE
PA 95 Regent Street, CAMBRIDGE, ENGLAND
SN 2050-084X
J9 ELIFE
JI eLife
PD MAR 24
PY 2025
VL 13
AR RP93373
DI 10.7554/eLife.93373
PG 32
WC Biology
WE Emerging Sources Citation Index (ESCI)
SC Life Sciences & Biomedicine - Other Topics
GA 0MY3F
UT WOS:001451195800001
PM 40126547
OA gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Nova-Baza, D
   Olivares-Caro, L
   Vallejos-Almirall, A
   Mennickent, D
   Sáez-Orellana, F
   Bustamante, L
   Radojkovic, C
   Vergara, C
   Fuentealba, J
   Mardones, C
AF Nova-Baza, Daniela
   Olivares-Caro, Lia
   Vallejos-Almirall, Alejandro
   Mennickent, Daniela
   Saez-Orellana, Francisco
   Bustamante, Luis
   Radojkovic, Claudia
   Vergara, Carola
   Fuentealba, Jorge
   Mardones, Claudia
TI Evaluation of the bioactivity of Berberis microphylla G. Forst
   (Calafate) leaves infusion
SO FOOD BIOSCIENCE
LA English
DT Article
DE Bioactivity; Calafate leaves; Infusion; Metabolic syndrome; Alzheimer's
   disease
ID PERFORMANCE LIQUID-CHROMATOGRAPHY; PANCREATIC LIPASE; ANTIOXIDANT
   CAPACITY; PHENOLIC COMPOSITION; CHLOROGENIC ACIDS; LC-MS/MS;
   POLYPHENOLS; MS; IDENTIFICATION; DERIVATIVES
AB Berberis microphylla G Forst (Calafate) have been used in traditional medicine from prehispanic times in Patagonia. In the last decade the consumption of the fruit has been increased due to their antioxidant capacity, and because several studies demonstrated health benefits associated with the protection against atherosclerosis and other metabolic diseases. Nevertheless, the bioactivity properties of the leaves, a by-product of agronomic management, have been poorly studied. Recently, 108 compounds mainly hydroxycinnamic acids, flavonols, and berberine were identified in a methanolic extract of the leaves, demonstrating great potential for the development of new functional beverages. Based on these, for first time a comprehensive chemical characterization and bioactivity was evaluated for a Calafate leaves infusion prepared in hot water. For this, chemical characterization of the infusion was performed by UHPLC-Q-TOF and TXRF. Bioactivity was assayed by antioxidant capacity, cell cytotoxicity, and cell oxidative stress assays. Inhibition of both A(3 aggregation for Alzheimer's disease and gastrointestinal enzymes for metabolic syndromes were evaluated. The results show that the infusion is rich in hydroxycinnamic acids and other bioactive compounds. The infusion does not contain toxic metals or cytotoxicity activity. The infusion can reduce intracellular reactive oxygen species in HUVEC cells and showed a reduction in the A(3 aggregation being a potential beverage for Alzheimer's prevention. Finally, the infusion had in-vitro hypoglycemic and hypolipidemic effects. These results support the usage of Berberis microphylla G Forst leaves as a new functional beverage.
C1 [Nova-Baza, Daniela; Olivares-Caro, Lia; Mennickent, Daniela; Bustamante, Luis; Vergara, Carola; Mardones, Claudia] Univ Concepcion, Fac Farm, Dept Anal Instrumental, Concepcion, Chile.
   [Nova-Baza, Daniela; Saez-Orellana, Francisco; Fuentealba, Jorge] Univ Concepcion, Fac Ciencias Biol, Dept Fisiol, Concepcion, Chile.
   [Olivares-Caro, Lia; Radojkovic, Claudia] Univ Concepcion, Fac Farm, Dept Bioquim Clin & Inmunol, Concepcion 4070386, Chile.
   [Vallejos-Almirall, Alejandro] Univ Concepcion, Fac Farm, Dept Ciencias & Tecnol Alimentos, Concepcion, Chile.
   [Mardones, Claudia] Univ Concepcion, Unidad Desarrollo Tecnol, Coronel, Chile.
C3 Universidad de Concepcion; Universidad de Concepcion; Universidad de
   Concepcion; Universidad de Concepcion; Universidad de Concepcion
RP Mardones, C (corresponding author), Univ Concepcion, Fac Farm, Dept Anal Instrumental, Concepcion, Chile.; Mardones, C (corresponding author), Univ Concepcion, Unidad Desarrollo Tecnol, Coronel, Chile.
EM cmardone@udec.cl
RI Vergara, Carola/AAB-2317-2020; Mennickent, Daniela/AEL-9050-2022;
   Mardones, Claudia/AAI-2850-2021
OI Mennickent, Daniela/0000-0002-6962-7632; Olivares-Caro,
   Lia/0009-0005-8386-457X; Vallejos-Almirall,
   Alejandro/0000-0002-6631-6871; Bustamante-Salazar,
   Luis/0000-0001-5077-474X
FU Agencia Nacional de Investigacion y Desarrollo (ANID), Chile; The
   (ANID)/FONDECYT [1191276, 1230625, 1209008]; ANID/FONDEQUIP
   [EQM-170023]; ANID/Beca Doctorado Nacional [21171702]
FX This research was supported by Agencia Nacional de Investigacion y
   Desarrollo (ANID), Chile.(ANID)/FONDECYT 1191276, (ANID)/FONDECYT
   1230625, (ANID)/FONDECYT 1209008 ANID/FONDEQUIP EQM-170023, ANID/Beca
   Doctorado Nacional 21171702.
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NR 90
TC 1
Z9 1
U1 3
U2 7
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2212-4292
EI 2212-4306
J9 FOOD BIOSCI
JI Food Biosci.
PD DEC
PY 2024
VL 62
AR 105097
DI 10.1016/j.fbio.2024.105097
EA OCT 2024
PG 14
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA I6M3X
UT WOS:001331377500001
DA 2025-06-11
ER

PT J
AU Chen, DM
   Wirth, KM
   Kizy, S
   Muretta, JM
   Markowski, TW
   Yong, PT
   Sheka, A
   Abdelwahab, H
   Hertzel, AV
   Ikramuddin, S
   Yamamoto, M
   Bernlohr, DA
AF Chen, Dongmei
   Wirth, Keith M.
   Kizy, Scott
   Muretta, Joseph M.
   Markowski, Todd W.
   Yong, Peter
   Sheka, Adam
   Abdelwahab, Hisham
   Hertzel, Ann V.
   Ikramuddin, Sayeed
   Yamamoto, Masato
   Bernlohr, David A.
TI Desmoglein 2 Functions as a Receptor for Fatty Acid Binding Protein 4 in
   Breast Cancer Epithelial Cells
SO MOLECULAR CANCER RESEARCH
LA English
DT Article
ID SIGNALING PATHWAY; METABOLIC SYNDROME; STRUCTURAL BASIS; BETA-CATENIN;
   FABP4; ACTIVATION; EXPRESSION; NRF2; IDENTIFICATION; MACROPHAGES
AB Fatty acid binding protein 4 (FABP4) is a secreted adipokine linked to obesity and progression of a variety of cancers. Obesity increases extracellular FABP4 (eFABP4) levels in animal models and in obese breast cancer patients compared with lean healthy controls. Using MCF-7 and T47D breast cancer epithelial cells, we show herein that eFABP4 stimulates cellular proliferation in a time and concentration dependent manner while the non-fatty acid -binding mutant, R126Q, failed to potentiate growth. When E0771 murine breast cancer cells were injected into mice, FABP4 null animals exhibited delayed tumor growth and enhanced survival compared with injections into control C57Bl/6J animals. eFABP4 treatment of MCF-7 cells resulted in a significant increase in phosphorylation of extracellular signal-regulated kinase 1/2 (pERK), transcriptional activation of nuclear factor E2-related factor 2 (NRF2) and corresponding gene targets ALDH1A1, CYP1A1, HMOX1, SOD1 and decreased oxidative stress, while R126Q treatment did not show any effects. Proximity-labeling employing an APEX2-FABP4 fusion protein revealed several pro-teins functioning in desmosomes as eFABP4 receptor candidates including desmoglein (DSG), desmocollin, junction plankoglobin, desomoplankin, and cytokeratins. AlphaFold modeling predicted an interaction between eFABP4, and the extracellular cadherin repeats of DSG2 and pull-down and immunoprecipitation assays confirmed complex formation that was potentiated by oleic acid. Silencing of DSG2 in MCF-7 cells attenuated eFABP4 effects on cellular proliferation, pERK levels, and ALDH1A1 expression com-pared with controls.Implications: These results suggest desmosomal proteins, and in particular desmoglein 2, may function as receptors of eFABP4 and provide new insight into the development and progression of obesity-associated cancers.
C1 [Chen, Dongmei; Muretta, Joseph M.; Markowski, Todd W.; Yong, Peter; Hertzel, Ann V.; Bernlohr, David A.] Univ Minnesota Twin Cities, Dept Biochem, Minneapolis, MN 55455 USA.
   [Chen, Dongmei; Muretta, Joseph M.; Markowski, Todd W.; Yong, Peter; Hertzel, Ann V.; Bernlohr, David A.] Univ Minnesota Twin Cities, Dept Mol Biol & Biophys, Minneapolis, MN 55455 USA.
   [Wirth, Keith M.; Kizy, Scott; Sheka, Adam; Abdelwahab, Hisham; Ikramuddin, Sayeed; Yamamoto, Masato] Univ Minnesota Twin Cities, Dept Surg, Minneapolis, MN USA.
   [Yamamoto, Masato] Univ Minnesota Twin Cities, Masonic Canc Ctr, Minneapolis, MN USA.
   [Abdelwahab, Hisham] Weil Cornell Med Qatar, Doha, Qatar.
C3 University of Minnesota System; University of Minnesota Twin Cities;
   University of Minnesota System; University of Minnesota Twin Cities;
   University of Minnesota System; University of Minnesota Twin Cities;
   University of Minnesota System; University of Minnesota Twin Cities;
   Qatar Foundation (QF); Weill Cornell Medical College Qatar
RP Bernlohr, DA (corresponding author), Univ Minnesota Twin Cities, Dept Biochem, Minneapolis, MN 55455 USA.; Bernlohr, DA (corresponding author), Univ Minnesota Twin Cities, Dept Mol Biol & Biophys, Minneapolis, MN 55455 USA.
EM Bernl001@umn.edu
RI Chen, Dongmei/IWD-5721-2023
OI Abdelwahab, Hisham/0000-0001-5811-1318; Yong, Peter/0000-0002-4899-3270;
   Markowski, Todd/0000-0001-9157-2036; Chen, Dongmei/0009-0000-5178-9310;
   Hertzel, Ann/0000-0002-9172-7939
FU NIH [DK053189, DK108733, R21 DK122832]; United States Department of
   Agriculture Experiment Station
FX Supported by NIH DK053189 and the United States Department of
   Agriculture Experiment Station to D.A. Bernlohr, by NIH T32 DK108733 to
   K.M. Wirth and NIH R21 DK122832 to S. Ikramuddin. We would like to thank
   the University of Minnesota Center for Mass Spectrometry and Proteomics
   core for protein analysis and the members of the Bernlohr Laboratory for
   discussion and advice. We would also like to thank Drs. Wendy Gordon and
   Robert Evans for assistance with preliminary AlphaFold modeling.
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NR 80
TC 7
Z9 8
U1 4
U2 8
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 1541-7786
EI 1557-3125
J9 MOL CANCER RES
JI Mol. Cancer Res.
PD AUG
PY 2023
VL 21
IS 8
BP 836
EP 848
DI 10.1158/1541-7786.MCR-22-0763
PG 13
WC Oncology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Cell Biology
GA O6ZR4
UT WOS:001045269900001
PM 37115197
OA Green Submitted, Green Accepted
DA 2025-06-11
ER

PT J
AU Radic, J
   Vuckovic, M
   Gelemanovic, A
   Kolak, E
   Nenadic, DB
   Begovic, M
   Radic, M
AF Radic, Josipa
   Vuckovic, Marijana
   Gelemanovic, Andrea
   Kolak, Ela
   Nenadic, Dora Bucan
   Begovic, Mirna
   Radic, Mislav
TI Associations between Advanced Glycation End Products, Body Composition
   and Mediterranean Diet Adherence in Kidney Transplant Recipients
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Article
DE advanced glycation end products; Mediterranean diet; kidney transplant;
   body composition
ID CARDIOVASCULAR-DISEASE; SKIN AUTOFLUORESCENCE; REVERSE EPIDEMIOLOGY;
   METABOLIC SYNDROME; OXIDATIVE STRESS; SERUM; MEAT; ACCUMULATION;
   INFLAMMATION; DYSFUNCTION
AB There is limited evidence on the associations between dietary patterns, body composition, and nonclassical predictors of worse outcomes such as advanced glycation end products (AGE) in kidney transplant recipients (KTRs). The aim of this cross-sectional study was to determine the level of AGE-determined cardiovascular (CV) risk in Dalmatian KTRs and possible associations between AGE, adherence to the Mediterranean diet (MeDi), and nutritional status. Eighty-five (85) KTRs were enrolled in this study. For each study participant, data were collected on the level of AGE, as measured by skin autofluorescence (SAF), Mediterranean Diet Serving Score (MDSS), body mass composition, anthropometric parameters, and clinical and laboratory parameters. Only 11.76% of the participants were adherent to the MeDi. Sixty-nine percent (69%) of KTRs had severe CV risk based on AGE, while 31% of KTRs had mild to moderate CV risk. The results of the LASSO regression analysis showed that age, dialysis type, dialysis vintage, presence of CV and chronic kidney disease, C- reactive protein level, urate level, percentage of muscle mass, and adherence to recommendations for nuts, meat, and sweets were identified as positive predictors of AGE. The negative predictors for AGE were calcium, phosphate, cereal adherence according to the MeDi, and trunk fat mass. These results demonstrate extremely low adherence to the MeDi and high AGE levels related CV risk in Dalmatian KTRs. Lifestyle interventions in terms of CV risk management and adherence to the MeDi of KTRs should be taken into consideration when taking care of this patient population.
C1 [Radic, Josipa; Vuckovic, Marijana] Univ Hosp Split, Dept Nephrol & Dialysis, Spinciceva 1, Split 21000, Croatia.
   [Radic, Josipa; Radic, Mislav] Univ Split, Sch Med, Dept Internal Med, Soltanska 2, Split 21000, Croatia.
   [Gelemanovic, Andrea] Mediterranean Inst Life Sci MedILS, Split 21000, Croatia.
   [Kolak, Ela; Nenadic, Dora Bucan] Univ Hosp Ctr Split, Dept Nutr & Dietet, Split 21000, Croatia.
   [Begovic, Mirna] Univ Split, Sch Med, Soltanska 2, Split 21000, Croatia.
   [Radic, Mislav] Univ Hosp Split, Dept Internal Med, Div Clin Immunol & Rheumatol, Split 21000, Croatia.
C3 University of Split; University of Split; University of Split;
   University of Split; University of Split
RP Radic, J (corresponding author), Univ Hosp Split, Dept Nephrol & Dialysis, Spinciceva 1, Split 21000, Croatia.; Radic, J (corresponding author), Univ Split, Sch Med, Dept Internal Med, Soltanska 2, Split 21000, Croatia.
EM josiparadic1973@gmail.com
RI Gelemanović, Andrea/AAV-7338-2021; Radic, Mislav/H-3306-2017; Radic,
   Josipa/H-3321-2017; Gelemanovic, Andrea/F-7218-2017
OI Bucan Nenadic, Dora/0000-0002-2589-2266; Radic,
   Mislav/0000-0003-0350-6800; Kolak, Ela/0000-0003-2012-9963; Radic,
   Josipa/0000-0003-2645-7597; Gelemanovic, Andrea/0000-0001-9195-646X
FU European Regional Development Fund [KK.01.1.1.04.0115]
FX This research is part of the project "Digitalization and improvement of
   nutritional care for patients with chronic diseases" co-financed by the
   European Regional Development Fund through the Operational Program
   "Competitiveness and Cohesion 2014-2020" KK.01.1.1.04.0115.
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NR 65
TC 4
Z9 4
U1 1
U2 8
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD SEP
PY 2022
VL 19
IS 17
AR 11060
DI 10.3390/ijerph191711060
PG 15
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA 4J2LQ
UT WOS:000851100700001
PM 36078776
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Amin, MN
   Bahoosh, SR
   Eftekhari, M
   Hosseinzadeh, L
AF Amin, Mohammed Namiq
   Bahoosh, Saba Rahimi
   Eftekhari, Mandieh
   Hosseinzadeh, Leila
TI Herbal Sources of Magnesium as a Promising Multifaceted Intervention for
   the Management of COVID-19
SO NATURAL PRODUCT COMMUNICATIONS
LA English
DT Review
DE SARS-CoV-2; COVID-19; magnesium; oxidative stress; inflammation; herbal
   source
ID CHRONIC KIDNEY-DISEASE; METABOLIC SYNDROME; VITAMIN-D; HEALTH;
   MORTALITY; CALCIUM; PREVENTION; VEGETABLES; SEVERITY; BENEFITS
AB The coronavirus-disease 2019 (COVID-19) was announced as a global pandemic by the World Health Organization (WHO), and it affected all human groups. Severe COVID-19 is characterized by cytokine storms, which can lead to multiorgan failure and death, although fever and cough are the most typical symptoms of mild COVID-19. Plant-based diets provide a 73% lower risk of moderate-to-severe COVID-19. Additionally, the association between low levels of some micronutrients and the adverse clinical consequences of COVID-19 has been demonstrated. So, nutritional therapy can become part of patient care for the survival of this life-threatening disease (COVID-19) also short-term recovery. Magnesium as an essential micronutrient due to its anti-inflammatory and beneficial effects can effectively prevent COVID-19 pandemic by playing a role in the treatment of comorbidities such as diabetes and cardiovascular disorders as major risk factors for mortality. Sufficient magnesium to stay healthy is provided by a proper daily diet, and there is usually no need to take magnesium supplements. Considering that almost half of the dietary magnesium comes from fruits, vegetables, nuts, and grains, it seems necessary to pay attention to the consumption of edible plants containing sufficient magnesium as part of the diet to prevent severe COVID-19. In this study, we have described the beneficial effects of sufficient magnesium levels to control COVID-19 and the importance of plant-based magnesium-rich diets. Additionally, we have listed some edible magnesium-rich plants.
C1 [Amin, Mohammed Namiq; Bahoosh, Saba Rahimi] Kermanshah Univ Med Sci, Student Res Comm, Kermanshah, Iran.
   [Eftekhari, Mandieh; Hosseinzadeh, Leila] Kermanshah Univ Med Sci, Pharmaceut Sci Res Ctr, Hlth Inst, Kermanshah, Iran.
   [Eftekhari, Mandieh] Kermanshah Univ Med Sci, Fac Pharm, Dept Pharmacognosy & Pharmaceut Biotechnol, Kermanshah, Iran.
C3 Kermanshah University of Medical Sciences; Kermanshah University of
   Medical Sciences; Kermanshah University of Medical Sciences
RP Eftekhari, M (corresponding author), Kermanshah Univ Med Sci, Pharmaceut Sci Res Ctr, Hlth Inst, Kermanshah, Iran.
EM mandieh.eftekhari@gmail.com
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NR 109
TC 2
Z9 2
U1 0
U2 1
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1934-578X
EI 1555-9475
J9 NAT PROD COMMUN
JI Nat. Prod. Commun.
PD AUG
PY 2022
VL 17
IS 8
AR 1934578X221116235
DI 10.1177/1934578X221116235
PG 11
WC Chemistry, Medicinal; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Food Science & Technology
GA 4D0OG
UT WOS:000846842100001
OA gold
DA 2025-06-11
ER

PT J
AU Bahman, Y
   Maryam, M
   Aisa, B
   Falalyeyeva, T
   Kobyliak, N
   Majid, E
AF Bahman, Yousefi
   Maryam, Mohammadlou
   Aisa, Bahar
   Falalyeyeva, Tetyana
   Kobyliak, Nazarii
   Majid, Eslami
TI Immunomodulatory role of Faecalibacterium prausnitzii in obesity
   and metabolic disorders
SO MINERVA BIOTECHNOLOGY AND BIOMOLECULAR RESEARCH
LA English
DT Review
DE Faecalibacterium prausnitzii; Microbiota; Dysbiosis; Obesity; Metabolic
   syndrome
ID CHAIN FATTY-ACIDS; GUT MICROBIOTA COMPOSITION; COLONIC MICROBIOTA;
   INSULIN-RESISTANCE; DIABETES-MELLITUS; FECAL MICROBIOTA; BARRIER
   FUNCTION; LIVER-DISEASE; BILE-ACIDS; INFLAMMATION
AB The gut microbiota is part of a complex network that interacts with the host metabolism and plays a key role in the immune system and regulation of hormone secretion. Any change in the gut microbiota (dysbiosis) is associated with various diseases such as metabolic syndromes. Dysbiosis can play a determining role in the pathogenesis of obesity-related metabolic disorders such as insulin resistance, diabetes, and cardiovascular disease. Microbiota is effective in the progression of type 1 diabetes (T1D) by affecting the permeability and status of the intestinal immune system. In healthy conditions, the intestinal epithelium prevents the induction of immune system responses, but in T1D it is stimulated by microbial or dietary antigens following an increase in the permeability of the intestinal immune system. The key link between dysbiosis and type 2 diabetes (T2D) is intestinal epithelial cell dysfunction. By increasing epithelial permeability and causing mild inflammation, it leads to dysfunction of the immune system and changes in glucose and lipid metabolism by affecting signaling pathways. Faecalibacterium (F) prausnitzii is the most abundant bacterium in the human gut microbiota that is actively involved in host metabolism. F. prausnitzii can inhibit the activity of NF-kappa B, IL-8, and can modulate the intestinal immune system, oxidative stress, and colon cell metabolism by producing butyrate. F. prausnitzii has anti-inflammatory properties by producing MAM protein and salicylic acid, which is effective in reducing colitis. Decreased levels of bacteria in the gut are also linked to inflammatory bowel disease, celiac disease, obesity, and diabetes.
C1 [Bahman, Yousefi; Maryam, Mohammadlou] Semnan Univ Med Sci, Dept Immunol, Semnan, Iran.
   [Aisa, Bahar] Semnan Univ Med Sci, Dept Biochem, Senman, Iran.
   [Falalyeyeva, Tetyana] Taras Shevchenko Natl Univ Kyiv, Kiev, Ukraine.
   [Kobyliak, Nazarii] Bogomolets Natl Med Univ, Dept Endocrinol, Kiev, Ukraine.
   [Kobyliak, Nazarii] Lab Pathol CSD Hlth Care, Kiev, Ukraine.
   [Majid, Eslami] Senman Univ Med Sci, Canc Res Ctr, Semnan, Iran.
   [Majid, Eslami] Senman Univ Med Sci, Dept Bacteriol & Virol, Semnan, Iran.
C3 Semnan University of Medical Sciences; Semnan University of Medical
   Sciences; Ministry of Education & Science of Ukraine; Taras Shevchenko
   National University of Kyiv; Bogomolets National Medical University;
   Medical Laboratory CSD
RP Majid, E (corresponding author), Senman Univ Med Sci, Dept Bacteriol & Virol, Canc Res Ctr, Semnan, Iran.
EM m.eslami@semums.ac.ir
RI Eslami, Majid/AFD-9924-2022; Kobyliak, Nazarii/R-8703-2016; Falalyeyeva,
   Tetyana/AEY-9788-2022
OI Bahar, Aysa/0000-0003-0822-6728; Kobyliak, Nazarii/0000-0001-9814-689X;
   Mohammadlou, Maryam/0000-0001-5895-5035; Falalyeyeva,
   Tetyana/0000-0002-4415-9676
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NR 108
TC 11
Z9 11
U1 0
U2 26
PU EDIZIONI MINERVA MEDICA
PI TURIN
PA CORSO BRAMANTE 83-85 INT JOURNALS DEPT., 10126 TURIN, ITALY
SN 2724-542X
EI 2724-5934
J9 MINERVA BIOTECHNOL B
JI Minerva Biotechnol. Biomolecular Res.
PD JUN
PY 2021
VL 33
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BP 76
EP 85
DI 10.23736/S2724-542X.21.02759-2
PG 10
WC Biotechnology & Applied Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology
GA TX9WY
UT WOS:000683437400004
DA 2025-06-11
ER

PT J
AU Khattab, A
   Ahmed-Farid, OA
   Nasr, SA
AF Khattab, Abeer
   Ahmed-Farid, O. A.
   Nasr, Sawsan A.
TI Enhanced brain biodistribution of Ginsenoside Rg1 based
   self-nanoemulsifying drug delivery system to ameliorate metabolic
   syndromes and keep homeostatic balance
SO JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
LA English
DT Article
DE Ginsenoside (Rg1); Brain targeted; Lipid profile; Metabolic syndrome
AB The aim of the study was to develop and characterize Ginsenoside Rg1 (GRg1) based self-nanoemulsifying system (SNES) to enhance its solubility, oral bioavailability and brain targeting. The anti-obesity efficacy and safety assessment compared to orlistat were also carried out. Solubility of GRg1 in various vehicles was carried out to recognize the optimum concentration of the component of SNES; pseudo-ternary phase diagrams were constructed to recognize the self-emulsifying area. Thermo stability test was performed to check the stability of the formulations. The stable ones were characterized for particle size, zeta potential, cloudiness, surface morphology, rheological properties, drug dissolution, ex vivo permeation as well as brain distribution. Anti-obesity efficacy of the optimized formula in comparison to orlistat was done using obese induced model in rats. The optimized formulations gave a spontaneous and stable nanoemulsion upon diluting with water, with optimum polydispersity index and negative zeta potential. The results revealed that SNES as a drug vehicle could improve the dissolution and absorption of GRg1. The results demonstrated that the GRg1 based SNES could ameliorate metabolic syndromes and keep homeostatic balances as it could maintain the lipid profile and lipase level. It also could reduce the oxidative stress markers, depress the appetite, and prevent hepatocyte degradation. In conclusion using SNES as carrier to GRg1 could avoid the first pass and increased its viability in blood and consequently targeted it to the brain in higher concentration compared to conventional extract. Moreover, it can be used as a promising antiobesity therapy to prevent metabolic and energy dysfunction of orlistat.
C1 [Khattab, Abeer] Egyptian Drug Author, Pharmaceut Dept, Cairo, Egypt.
   [Ahmed-Farid, O. A.; Nasr, Sawsan A.] Egyptian Drug Author, Physiol Dept, Cairo, Egypt.
RP Khattab, A (corresponding author), Egyptian Drug Author, Pharmaceut Dept, Cairo, Egypt.
EM abeer_khattab75@yahoo.com
RI Ahmed-Farid, Omar/AAE-8278-2022
OI Ahmed-Farid, Omar/0000-0002-1020-5777
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NR 87
TC 6
Z9 6
U1 0
U2 20
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1773-2247
EI 2588-8943
J9 J DRUG DELIV SCI TEC
JI J. Drug Deliv. Sci. Technol.
PD FEB
PY 2021
VL 61
AR 102276
DI 10.1016/j.jddst.2020.102276
PG 13
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA QI7KF
UT WOS:000619160800009
DA 2025-06-11
ER

PT J
AU Xiong, XL
   Li, J
   Li, CY
AF Xiong, Xiaoling
   Li, Jun
   Li, Chunyan
TI EFFECTS OF ATORVASTATIN COMBINED WITH AEROBIC RESISTANCE EXERCISE ON
   LUNG FUNCTION
SO ACTA POLONIAE PHARMACEUTICA
LA English
DT Article
DE aerobic resistance exercise; atorvastatin; Chronic obstructive pulmonary
   disease (COPD)
ID OBSTRUCTIVE PULMONARY-DISEASE; METABOLIC SYNDROME; PHYSICAL-ACTIVITY;
   TAURINE; PREVENTION; SMOKING; STRESS; DAMAGE; COPD; MEN
AB Chronic obstructive pulmonary disease (COPD) is a chronic respiratory disease seriously threatening the quality of life of patients. In the treatment of patients with COPD at a stable stage. aerobic resistance exercise is not only needed to help patients recover their exercise function but also medication is needed to inhibit the production of inflammatory factors. This study discussed the feasibility of combining aerobic resistance exercise with medication to treat COPD. One hundred forty-seven patients with COPD who were hospitalized in the internal medicine department of our hospital from October 2015 to June 2019 were selected, and 120 patients were selected as subjects of this experiment on a voluntary basis. Aerobic resistance exercise therapy, atorvastatin. and combination therapy were performed respectively, and the patients' physical fitness indicators, levels of inflammatory cytokines, and cardiopulmonary function were observed to evaluate treatment plans. After receiving the treatment of aerobic and obstructive exercise combined with atorvastatin, COPD patients showed improvement in the indicators related to physical fitness, including decreased body fat percentage. waist-to-hip ratio, BMI, blood sugar, hba1c content, and blood lipid, decreased levels of inflammatory factors like IL-8, IL-6, TNF-alpha. and some recovery in cardiopulmonary function. A combination of aerobic and obstructive exercise with atorvastatin can better treat COPD and improve the exercise function and cardiopulmonary function of patients. However, the clinical application of this treatment plan needs more cases to verify, and clinical application also needs to adjust the plan appropriately according to individual differences.
C1 [Xiong, Xiaoling; Li, Chunyan] Wuhan Sports Univ, Coll Hlth Sci, Hubei Key Lab Sport Training & Monitoring, Wuhan 430079, Peoples R China.
   [Li, Jun] Wuhan Univ, Dept Obstet, Renmin Hosp, Wuhan 430060, Peoples R China.
C3 Wuhan Sports University; Wuhan University
RP Li, CY (corresponding author), Wuhan Sports Univ, Coll Hlth Sci, Hubei Key Lab Sport Training & Monitoring, Wuhan 430079, Peoples R China.
EM lichunyan452@yandex.com
RI Li, Chunyan/F-5309-2016
FU iphysical education and health promotioni of the dominant academic group
   in Hubei province [81971661, B2017232]
FX This work was supported by iphysical education and health promotioni of
   the dominant academic group in Hubei province (81971661, B2017232).
   Thanks for the support of iphysical education and health promotioni of
   the dominant academic group in Hubei province.
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NR 33
TC 0
Z9 0
U1 1
U2 9
PU POLSKIE TOWARZYSTWO FARMACEUTYCZNE
PI WARSAW
PA DLUGA 16, 00-238 WARSAW, POLAND
SN 0001-6837
EI 2353-5288
J9 ACTA POL PHARM
JI ACTA POL. PHARM.
PD NOV-DEC
PY 2020
VL 77
IS 6
BP 863
EP 870
DI 10.32383/appdr/131241
PG 8
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA PS6EN
UT WOS:000608019200005
OA hybrid
DA 2025-06-11
ER

PT J
AU Fujinaga, Y
   Kawaratani, H
   Kaya, D
   Tsuji, Y
   Ozutsumi, T
   Furukawa, M
   Kitagawa, K
   Sato, S
   Nishimura, N
   Sawada, Y
   Takaya, H
   Kaji, K
   Shimozato, N
   Moriya, K
   Namisaki, T
   Akahane, T
   Mitoro, A
   Yoshiji, H
AF Fujinaga, Yukihisa
   Kawaratani, Hideto
   Kaya, Daisuke
   Tsuji, Yuki
   Ozutsumi, Takahiro
   Furukawa, Masanori
   Kitagawa, Koh
   Sato, Shinya
   Nishimura, Norihisa
   Sawada, Yasuhiko
   Takaya, Hiroaki
   Kaji, Kosuke
   Shimozato, Naotaka
   Moriya, Kei
   Namisaki, Tadashi
   Akahane, Takemi
   Mitoro, Akira
   Yoshiji, Hitoshi
TI Effective Combination Therapy of Angiotensin-II Receptor Blocker and
   Rifaximin for Hepatic Fibrosis in Rat Model of Nonalcoholic
   Steatohepatitis
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE hepatic fibrosis; rifaximin; ARB; metabolic syndrome; NASH
ID PREGNANE X-RECEPTOR; GUT-LIVER AXIS; NF-KAPPA-B; EPITHELIAL
   PERMEABILITY; INTESTINAL PERMEABILITY; STELLATE CELL; SUPPRESSION;
   MICROBIOTA; REGULATOR; INFLAMMATION
AB The progression of nonalcoholic steatohepatitis (NASH) is complicated. The multiple parallel-hits theory is advocated, which includes adipocytokines, insulin resistance, endotoxins, and oxidative stress. Pathways involving the gut-liver axis also mediate the progression of NASH. Angiotensin-II receptor blockers (ARB) suppress hepatic fibrosis via the activation of hepatic stellate cells (HSCs). Rifaximin, a nonabsorbable antibacterial agent, is used for the treatment of hepatic encephalopathy and has been recently reported to improve intestinal permeability. We examined the inhibitory effects on and mechanism of hepatic fibrogenesis by combining ARB and rifaximin administration. Fischer 344 rats were fed a choline-deficient/l-amino acid-defined (CDAA) diet for 8 weeks to generate the NASH model. The therapeutic effect of combining an ARB and rifaximin was evaluated along with hepatic fibrogenesis, the lipopolysaccharide-Toll-like receptor 4 (TLR4) regulatory cascade, and intestinal barrier function. ARBs had a potent inhibitory effect on hepatic fibrogenesis by suppressing HSC activation and hepatic expression of transforming growth factor-beta and TLR4. Rifaximin reduced intestinal permeability by rescuing zonula occludens-1 (ZO-1) disruption induced by the CDAA diet and reduced portal endotoxin. Rifaximin directly affect to ZO-1 expression on intestinal epithelial cells. The combination of an ARB and rifaximin showed a stronger inhibitory effect compared to that conferred by a single agent. ARBs improve hepatic fibrosis by inhibiting HSCs, whereas rifaximin improves hepatic fibrosis by improving intestinal permeability through improving intestinal tight junction proteins (ZO-1). Therefore, the combination of ARBs and rifaximin may be a promising therapy for NASH fibrosis.
C1 [Fujinaga, Yukihisa; Kawaratani, Hideto; Kaya, Daisuke; Tsuji, Yuki; Ozutsumi, Takahiro; Furukawa, Masanori; Kitagawa, Koh; Sato, Shinya; Nishimura, Norihisa; Sawada, Yasuhiko; Takaya, Hiroaki; Kaji, Kosuke; Shimozato, Naotaka; Moriya, Kei; Namisaki, Tadashi; Akahane, Takemi; Mitoro, Akira; Yoshiji, Hitoshi] Nara Med Univ, Dept Gastroenterol, Nara 6348522, Japan.
C3 Nara Medical University
RP Kawaratani, H (corresponding author), Nara Med Univ, Dept Gastroenterol, Nara 6348522, Japan.
EM fujinaga@naramed-u.ac.jp; kawara@naramed-u.ac.jp; kayad@naramed-u.ac.jp;
   tsujih@naramed-u.ac.jp; ozutaka@naramed-u.ac.jp;
   furukawa@naramed-u.ac.jp; kitagawa@naramed-u.ac.jp;
   shinyasato@naramed-u.ac.jp; nishimuran@naramed-u.ac.jp;
   yasuhiko@naramed-u.ac.jp; htky@naramed-u.ac.jp; kajik@naramed-u.ac.jp;
   shimozato@naramed-u.ac.jp; moriyak@naramed-u.ac.jp;
   tadashin@naramed-u.ac.jp; stakemi@naramed-u.ac.jp;
   mitoroak@naramed-u.ac.jp; yoshijih@naramed-u.ac.jp
RI Nishimura, Norihisa/AAC-1300-2021; Akahane, Takemi/O-4509-2018; SATO,
   SHINYA/MXL-4589-2025; Kitagawa, Koh/ITU-7907-2023
OI Fujinaga, Yukihisa/0000-0003-2402-574X; Kitagawa,
   Koh/0000-0001-5794-1512; Kawaratani, Hideto/0000-0002-4361-0592;
   Akahane, Takemi/0000-0002-6675-0475; Yoshiji,
   Hitoshi/0000-0002-5243-8544; Namisaki, Tadashi/0000-0002-3158-5318;
   Mitoro, Akira/0000-0002-6666-5633
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U2 10
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PD AUG
PY 2020
VL 21
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AR 5589
DI 10.3390/ijms21155589
PG 14
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA NL8RE
UT WOS:000567675500001
PM 32759852
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Dapper, C
   Schuster, F
   Stölting, I
   Vogt, F
   Souza, LACE
   Alenina, N
   Bader, M
   Raasch, W
AF Dapper, Carla
   Schuster, Franziska
   Stoelting, Ines
   Vogt, Florian
   Castro e Souza, Lucas Araujo
   Alenina, Natalia
   Bader, Michael
   Raasch, Walter
TI The antiobese effect of AT1 receptor blockade is augmented in mice
   lacking Mas
SO NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
LA English
DT Article
DE Angiotensins; Antiobese; Mas-ko mice
ID RENIN-ANGIOTENSIN SYSTEM; DIET-INDUCED OBESITY; II AT(1) RECEPTORS;
   INSULIN SENSITIVITY; BLOOD-PRESSURE; WEIGHT-GAIN;
   MITOCHONDRIAL-FUNCTION; GLUCOSE-HOMEOSTASIS; METABOLIC SYNDROME;
   OXIDATIVE STRESS
AB We recently showed that the antiobese efficacy of the AT1 receptor blocker telmisartan (TEL) is at least partially related to an Ang(1-7)-dependent mechanism. Ang(1-7) acts via Mas, thus raising the question of whether Mas-deficient (Mas-ko) mice are likewise predisposed to develop diet-induced obesity and, further, whether this can be prevented by TEL treatment. Mas-ko mice and FVB/N wild-type (wt) animals were treated with TEL (8 mg/kg/day) or vehicle while they were fed with high-fat diet (HFD) or chow. Mice were phenotyped regarding body weight, fat mass, insulin sensitivity, and leptin sensitivity. In response to HFD feeding, gain in body weight and impairment of leptin sensitivity were similar between wt and Mas-ko mice. TEL reduced body weight in both strains but effects were stronger in Mas-ko mice. TEL diminished fat mass and restored leptin sensitivity only in Mas-ko mice. Blood glucose was higher in wt than Mas-ko mice fed with HFD while not differing when they were fed with chow. Insulin challenge confirmed that wt mice became insulin resistant when fed with HFD while HFD feeding did not impair insulin sensitivity in Mas-ko mice. TEL had no further effect. Our findings on the influence of TEL on growth and metabolism in Mas-ko mice conflict with our previous findings in rats. We assume that the FVB/N background of the mice may partly explain these inconsistent data. Moreover, it also seems feasible that the MrgD receptor compensates for Mas deficiency.
C1 [Dapper, Carla; Schuster, Franziska; Stoelting, Ines; Raasch, Walter] Univ Lubeck, Inst Expt & Clin Pharmacol & Toxicol, Ratzeburger Allee 160, D-23538 Lubeck, Germany.
   [Dapper, Carla; Schuster, Franziska; Raasch, Walter] CBBM, Lubeck, Germany.
   [Vogt, Florian] Univ Lubek, Dept Radiol & Nucl Med, Lubeck, Germany.
   [Castro e Souza, Lucas Araujo; Alenina, Natalia; Bader, Michael] Max Delbruck Ctr Mol Med MDC, Berlin, Germany.
   [Castro e Souza, Lucas Araujo] Univ Fed Minas Gerais, Inst Biol Sci, Dept Physiol & Biophys, Natl Inst Sci & Technol Nanobiophannaceut, Belo Horizonte, MG, Brazil.
   [Bader, Michael] DZHK German Ctr Cardiovasc Res, Partner Site, Berlin, Germany.
   [Bader, Michael] Univ Lubeck, Ctr Struct & Cell Biol Med, Inst Biol, Lubeck, Germany.
   [Bader, Michael] Charite Univ Med Berlin, Berlin, Germany.
   [Raasch, Walter] DZHK German Ctr Cardiovasc Res, Partner Site, Lubeck, Germany.
C3 University of Lubeck; Helmholtz Association; Max Delbruck Center for
   Molecular Medicine; Universidade Federal de Minas Gerais; German Centre
   for Cardiovascular Research; University of Lubeck; Berlin Institute of
   Health; Free University of Berlin; Humboldt University of Berlin;
   Charite Universitatsmedizin Berlin; German Centre for Cardiovascular
   Research
RP Raasch, W (corresponding author), Univ Lubeck, Inst Expt & Clin Pharmacol & Toxicol, Ratzeburger Allee 160, D-23538 Lubeck, Germany.; Raasch, W (corresponding author), CBBM, Lubeck, Germany.; Raasch, W (corresponding author), DZHK German Ctr Cardiovasc Res, Partner Site, Lubeck, Germany.
EM walter.raasch@phanna.uni-luebeck.de
RI Bader, Michael/K-2124-2013; Souza, Lucas/AGX-5164-2022; Raasch,
   Walter/AAR-1165-2020; Raasch, Walter/D-3694-2018
OI Raasch, Walter/0000-0002-8781-2997; Bader, Michael/0000-0003-4780-4164;
   A.C. Souza, Lucas/0000-0003-1512-3030
FU German Research Foundation [Graduiertenkolleg 1957]; German Centre for
   Cardiovascular Research (DZHK)
FX Carla Dapper and Franziska Schuster were supported by a grant of the
   German Research Foundation to the Graduiertenkolleg 1957
   "Adipocyte-Brain Crosstalk," University of Lubeck. The study was
   supported by a grant of the German Centre for Cardiovascular Research
   (DZHK). Walter Raasch received Telmisartan from Boehringer Ingelheim
   Pharmaceuticals, Inc. (Ingelheim, Germany).
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NR 77
TC 7
Z9 8
U1 0
U2 3
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0028-1298
EI 1432-1912
J9 N-S ARCH PHARMACOL
JI Naunyn-Schmiedebergs Arch. Pharmacol.
PD JUL
PY 2019
VL 392
IS 7
BP 865
EP 877
DI 10.1007/s00210-019-01643-0
PG 13
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA IC0ZM
UT WOS:000470688700010
PM 30868173
DA 2025-06-11
ER

PT J
AU Chen, L
   Shi, GR
   Huang, DD
   Li, Y
   Ma, CC
   Shi, M
   Su, BX
   Shi, GJ
AF Chen, Lei
   Shi, Guang-rui
   Huang, Dan-dan
   Li, Yang
   Ma, Chen-chao
   Shi, Min
   Su, Bin-xiao
   Shi, Guang-jiang
TI Male sexual dysfunction: A review of literature on its pathological
   mechanisms, potential risk factors, and herbal drug intervention
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Review
DE Male sexual dysfunction; Pathological mechanisms; Erectile dysfunction;
   Medicinal herbs; Environmental contaminants; Chronic diseases; Drug
   toxicity
ID LYCIUM-BARBARUM POLYSACCHARIDE; INDUCED TESTICULAR TOXICITY; ERECTILE
   DYSFUNCTION; METABOLIC SYNDROME; DIABETES-MELLITUS; OXIDATIVE STRESS;
   AQUEOUS EXTRACT; MEN; BEHAVIOR; ASSOCIATION
AB Sexual dysfunction (SD) is a disorder of sexual behavior and sexual sensation that appears as an abnormality or absence of sexual psychology and physiological reaction. It is a general term for many different symptoms includes several aspects, erectile dysfunction (ED), failure of sexual intercourse and loss of libido/desire. According to statistics, 52% of 40 similar to 70 year old men suffer from varying degrees of SD. And these diseases caused by a variety of biological and psychological factors. In world about 15% of couples are affected by sexual disharmony among these 40 to 50% are because of male factors. Considering the sensitivity of male reproduction system, it is being easily affected by multiple risk factors, such as chronic diseases, environmental contaminants, drug toxicity and unhealthy lifestyle and so on. In the last few years, significant progress have been made toward understanding the various forms of male SD and the possible potential pathological mechanisms. However, for the time being, the exact cause of SD is not fully understood from the literature. What is also significant about there are quite limited treatments in reproductive medicine being directed against these lesions. The purpose of this review is to summarize the current findings of pathogenic factors of SD in clinical or animal studies, to elaborate the underlying mechanisms of these diseases from studies in vivo and in vitro, to analyses the risk factors, and to describe the management strategies traditionally recommended of male sexual dysfunction. The review findings elucidate a systematic strategies for effectively preventing these diseases.
C1 [Chen, Lei; Shi, Min] Xian Pei Hua Univ, Med Coll, Xian 710125, Shaanxi, Peoples R China.
   [Shi, Guang-rui] Yunnan Minzu Univ, Joint Lab Tradit Nat Med, Kunming 650500, Yunnan, Peoples R China.
   [Huang, Dan-dan] Fujian Med Univ, Affiliated Hosp 2, Dept Pharm, Fuzhou 362000, Fujian, Peoples R China.
   [Li, Yang] Northwest Univ, Coll Life Sci, Xian 710069, Shaanxi, Peoples R China.
   [Ma, Chen-chao] Air Force Med Univ, Xi Jing Hosp, Dept Pharm, Xian 710032, Shaanxi, Peoples R China.
   [Su, Bin-xiao] Air Force Med Univ, Xi Jing Hosp, Dept Anesthesiol, Xian 710032, Shaanxi, Peoples R China.
   [Shi, Guang-jiang] China Pharmaceut Univ, Dept Pharmacol, Nanjing 211198, Jiangsu, Peoples R China.
C3 Yunnan Minzu University; Fujian Medical University; Northwest University
   Xi'an; Air Force Medical University; Air Force Medical University; China
   Pharmaceutical University
RP Su, BX (corresponding author), Air Force Med Univ, Xi Jing Hosp, Dept Anesthesiol, Xian 710032, Shaanxi, Peoples R China.; Shi, GJ (corresponding author), China Pharmaceut Univ, Dept Pharmacol, Nanjing 211198, Jiangsu, Peoples R China.
EM subinxiaodr@163.com; 15769601020@163.com
RI Chen, Lei/AAT-6684-2021; Huang, Dandan/AAI-6968-2021
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NR 143
TC 102
Z9 111
U1 7
U2 30
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD APR
PY 2019
VL 112
AR 108585
DI 10.1016/j.biopha.2019.01.046
PG 13
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA HP1TD
UT WOS:000461449400010
PM 30798136
OA gold
DA 2025-06-11
ER

PT J
AU Dietrich, I
   Braga, GA
   de Melo, FG
   Silva, ACCDS
AF Dietrich, Isa
   Braga, Gustavo Arruda
   de Melo, Fernanda Gomes
   da Costa Silva Silva, Ana Carolina Calmon
TI The Diabetic Foot as a Proxy for Cardiovascular Events and Mortality
   Review
SO CURRENT ATHEROSCLEROSIS REPORTS
LA English
DT Review
DE Diabetic foot syndrome; Diabetes; Neuropathy; Microvascular disease;
   Cardiovascular events; Cardiovascular mortality; Foot ulcer
ID PERIPHERAL NEUROPATHY; CYSTATIN-C; RISK-FACTORS; DYSFUNCTION; PREDICTOR;
   MELLITUS; ISCHEMIA; DISEASE; ULCER
AB Purpose of Review This article reviewed very recent papers (2016) discussing or bringing clinical evidences of the possible common pathways leading to diabetic foot syndrome (DFS) and increased mortality rates.
   Recent Findings Diabetic patients with diabetic foot syndrome have a mortality rate greater than twofold when compared with non-ulcerated diabetics. In addition, the 5-year mortality rate following amputation is estimated at 39-68%, a life expectancy comparable to aggressive types of cancer or advanced congestive heart failure. The majority of patients with diabetic foot ulcer also present insulin resistance, central obesity, dyslipidemia, and hypertension that characterize the metabolic syndrome that, in turn, is associated with an elevated risk of major cardiovascular events. Sensory neuropathy is the primary cause of more the 60% of diabetic foot ulcer. Diabetic peripheral neuropathy is a microvascular complication of diabetes mellitus and in type 2 diabetes, not only hyperglycemia but also other metabolic alterations and persistent inflammatory status due to adiposity play a major role in axon injury. Elevated triglycerides have been showed to be an independent risk factor for lower extremity amputation in diabetic patients. Also, toxic adiposity, oxidative stress, mitochondrial dysfunction, activation of the polyol pathway, accumulation of advanced glycation end products (AGEs), and elevation of inflammatory markers are also implicated in diabetic vascular disease and neuropathy.
   Summary The hypotheses that the association between DFS and increased rates of mortality reflects the progression of micro- and macrovascular complications are reinforced by the additional association of DFU to renal failure and retinopathy.
C1 [Dietrich, Isa] Univ Sao Paulo, Sch Med, Liver Pancreas & Islets Transplantat, Dept Gastroenterol,Surg Div, LIM 37,Av Dr Arnaldo 455 3rd Floor Suite 3208, BR-01246903 Sao Paulo, Brazil.
   [Dietrich, Isa; Braga, Gustavo Arruda; de Melo, Fernanda Gomes; da Costa Silva Silva, Ana Carolina Calmon] Org Oswaldo Cruz German Hosp, Div Obes & Diabet Ctr, R Cincinato Braga,37 5th Floor, BR-01246903 Sao Paulo, Brazil.
C3 Universidade de Sao Paulo
RP Dietrich, I (corresponding author), Univ Sao Paulo, Sch Med, Liver Pancreas & Islets Transplantat, Dept Gastroenterol,Surg Div, LIM 37,Av Dr Arnaldo 455 3rd Floor Suite 3208, BR-01246903 Sao Paulo, Brazil.; Dietrich, I (corresponding author), Org Oswaldo Cruz German Hosp, Div Obes & Diabet Ctr, R Cincinato Braga,37 5th Floor, BR-01246903 Sao Paulo, Brazil.
EM Isa.dietrich@isa.med.br
RI Dietrich, Isa/J-6512-2012
OI Braga, Gustavo/0009-0009-8144-9793
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NR 36
TC 83
Z9 88
U1 0
U2 13
PU CURRENT MEDICINE GROUP
PI PHILADELPHIA
PA 400 MARKET STREET, STE 700, PHILADELPHIA, PA 19106 USA
SN 1523-3804
EI 1534-6242
J9 CURR ATHEROSCLER REP
JI Curr. Atheroscleros. Rep.
PD NOV
PY 2017
VL 19
IS 11
AR 44
DI 10.1007/s11883-017-0680-z
PG 5
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA FL4UW
UT WOS:000414228000003
PM 28971322
DA 2025-06-11
ER

PT J
AU Kim, J
   Lee, H
   Lim, J
   Oh, J
   Shin, SS
   Yoon, M
AF Kim, Jeongjun
   Lee, Haerim
   Lim, Jonghoon
   Oh, Jaeho
   Shin, Soon Shik
   Yoon, Michung
TI The Angiogenesis Inhibitor ALS-L1023 from Lemon-Balm Leaves Attenuates
   High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease through
   Regulating the Visceral Adipose-Tissue Function
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE herbal medicine; Melissa officinalis; visceral adipose inflammation;
   visceral obesity
ID INDUCED HEPATIC STEATOSIS; ENDOTHELIAL GROWTH-FACTOR; OBESE MICE;
   PPAR-ALPHA; ADIPOCYTE HYPERTROPHY; METABOLIC SYNDROME; ABDOMINAL
   OBESITY; OXIDATIVE STRESS; LIPID-METABOLISM; STEATOHEPATITIS
AB Similar to neoplastic tissues, growth and development of adipose tissue are thought to be angiogenesis-dependent. Since visceral adipose tissue (VAT) is associated with development and progression of nonalcoholic fatty liver disease (NAFLD), we hypothesized that angiogenesis inhibition would attenuate obesity-induced NAFLD. We fed C57BL/6J mice a low-fat diet (LFD, chow 10% kcal fat), a high-fat diet (HFD, 45% kcal fat) or HFD supplemented with the lemon-balm extract ALS-L1023 (HFD-ALS) for 15 weeks. ALS-L1023 reduced endothelial cell-tube formation in vitro. HFD increased VAT angiogenesis and induced weight gains including body weight, VAT mass and visceral adipocyte size compared with LFD. However, HFD-ALS led to weight reductions without affecting calorie intake compared with HFD. HFD-ALS also reduced serum ALT and AST levels and improved lipid metabolism. HFD-ALS suppressed steatosis, infiltration of inflammatory cells, and accumulation of collagen in livers. HFD-ALS modulated hepatic expression of genes involved in lipid metabolism, inflammation, fibrosis, antioxidation, and apoptosis. Concomitantly, analysis of VAT function revealed that HFD-ALS led to fewer CD68-positive macrophage numbers and lower expression of inflammatory cytokines compared with HFD. Our findings show that the anti-angiogenic herbal extract ALS-L1023 attenuates NAFLD by targeting VAT during obesity, suggesting that angiogenesis inhibitors could aid in the treatment and prevention of obesity-induced human NAFLD.
C1 [Kim, Jeongjun; Lee, Haerim; Lim, Jonghoon; Oh, Jaeho; Yoon, Michung] Mokwon Univ, Dept Biomed Engn, Daejeon 35349, South Korea.
   [Shin, Soon Shik] Dong Eui Univ, Coll Korean Med, Dept Formula Sci, Busan 47340, South Korea.
C3 Mokwon University; Dong-Eui University
RP Yoon, M (corresponding author), Mokwon Univ, Dept Biomed Engn, Daejeon 35349, South Korea.
EM sdsd2586@naver.com; lhr6515@naver.com; tbvjwhdtlsdl@naver.com;
   kelberoth30@naver.com; ssshin@deu.ac.kr; yoon60@mokwon.ac.kr
FU National Research Foundation of Korea (NRF) - Korea Government (MEST)
   [2015R1A1A3A04001016]; Korea Health Industry Development Institute
   (KHIDI) - Korea Government (MHW) [HI15C0075, HI16C0753]
FX This work was supported by the National Research Foundation of Korea
   (NRF) Grant funded by the Korea Government (MEST) (2015R1A1A3A04001016)
   and the Korea Health Industry Development Institute (KHIDI) Grant funded
   by the Korea Government (MHW) (HI15C0075 and HI16C0753).
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NR 45
TC 34
Z9 35
U1 0
U2 16
PU MDPI AG
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD APR
PY 2017
VL 18
IS 4
AR 846
DI 10.3390/ijms18040846
PG 18
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA EW6SA
UT WOS:000402639400170
PM 28420164
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Chen, CC
   Hsu, LW
   Nakano, T
   Huang, KT
   Chen, KD
   Lai, CY
   Goto, S
   Chen, CL
AF Chen, Chien-Chih
   Hsu, Li-Wen
   Nakano, Toshiaki
   Huang, Kuang-Tzu
   Chen, Kuang-Den
   Lai, Chia-Yun
   Goto, Shigeru
   Chen, Chao-Long
TI DHL-HisZn, a novel antioxidant, enhances adipogenic differentiation and
   antioxidative response in adipose-derived stem cells
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Article
DE DHL-HisZn; Adipogenic differentiation; Antioxidant Insulin resistance;
   PPARg
ID HISTIDINATE ZINC COMPLEX; INSULIN-RESISTANCE; OXIDATIVE STRESS;
   METABOLIC SYNDROME; DOWN-REGULATION; EXPRESSION; RATS; TISSUE;
   ADIPONECTIN; ALPHA
AB Adipose-derived stem cells (ASCs) are multipotent progenitor cells that have the capacity to differentiate into specific mesenchymal cell lineages including adipocytes in response to environmental cues. Dysfunctional adipose tissue, rather than an excess of adipose tissue, has been proposed as a key factor in the pathogenesis of obesity-related diseases. The insulin-sensitizing effects of antidiabetic drugs are mediated by activation of peroxisome proliferator-activated receptor gamma (PPAR gamma). Here, we investigated the effects of sodium zinc histidine dithiooctanamide (DHL-HisZn), a strong antioxidant, on PPARg activation, adipocyte differentiation and insulin sensitivity. Additionally, the effects of DHL-HisZn on cellular antioxidant response and inflammatory cytokine production were also evaluated. In ASCs, DHL-HisZn enhanced adipocyte differentiation and PPAR gamma expression in a dose-dependent manner. DHLHisZn also increased the relative abundance of insulin-responsive glucose transporter 4 (GLUT4) and adiponectin mRNA. Furthermore, DHL-HisZn upregulated PPARg downstream target gene expression. In addition, treatment with DHL-HisZn upregulated mRNA levels of endogenous antioxidants, such as glucose-6-phosphate dehydrogenase (G6PD), superoxide dismutase 2 (SOD2), catalase (CAT) and glutathione reductase (GR). DHL-HisZn treatment enhanced insulin signaling and inhibited NF-kB activation, which subsequently suppressed inflammatory cytokine IL-6 expression. Our results indicate that DHL-HisZn enhances insulin sensitivity in adipocytes by increasing the expression of GLUT4 and IRS1 via the activation of PPAR gamma and improving the antioxidant response during adipogenic differentiation. Therefore, DHL-HisZn may have the capability to reduce insulin resistance. (C) 2016 Elsevier Masson SAS. All rights reserved.
C1 [Chen, Chien-Chih] Kaohsiung Chang Gung Mem Hosp, Dept Psychiat, Kaohsiung 833, Taiwan.
   [Chen, Chien-Chih; Hsu, Li-Wen; Huang, Kuang-Tzu; Chen, Kuang-Den; Lai, Chia-Yun; Goto, Shigeru; Chen, Chao-Long] Chang Gung Univ, Coll Med, 123 Dapi Rd, Kaohsiung 833, Taiwan.
   [Hsu, Li-Wen; Lai, Chia-Yun; Goto, Shigeru; Chen, Chao-Long] Kaohsiung Chang Gung Mem Hosp, Dept Surg, Liver Transplantat Ctr, 123 Dapi Rd, Kaohsiung 833, Taiwan.
   [Huang, Kuang-Tzu; Chen, Kuang-Den] Kaohsiung Chang Gung Mem Hosp, Inst Translat Res Biomed, Kaohsiung 833, Taiwan.
   [Nakano, Toshiaki] Chang Gung Univ, Grad Inst Clin Med Sci, Coll Med, Kaohsiung 833, Taiwan.
   [Goto, Shigeru] Josai Int Univ, Fac Nursing, Chiba 283, Japan.
C3 Chang Gung Memorial Hospital; Chang Gung University; Chang Gung Memorial
   Hospital; Chang Gung Memorial Hospital; Chang Gung University
RP Goto, S (corresponding author), Chang Gung Univ, Coll Med, 123 Dapi Rd, Kaohsiung 833, Taiwan.; Goto, S (corresponding author), Kaohsiung Chang Gung Mem Hosp, Dept Surg, Liver Transplantat Ctr, 123 Dapi Rd, Kaohsiung 833, Taiwan.; Chen, CL (corresponding author), Kaohsiung Chang Gung Mem Hosp, Liver Transplantat Program, Inst Translat Res Biomed, 123 Ta Pei Rd, Kaohsiung 83305, Taiwan.; Chen, CL (corresponding author), Chang Gung Univ, Coll Med, 123 Ta Pai Rd, Kaohsiung 83305, Taiwan.
EM pochigoto0224@gmail.com; clchen@adm.cgmh.org.tw
RI Chen, Chien-Chih/E-8499-2013; Chen, Chao-Long/LMN-0626-2024
OI Nakano, Toshiaki/0000-0003-3701-3449
FU Ministry of Science and Technology [MOST104-2314-B-182A-018, MOST
   105-2314-B-182A-037 -MY2, MOST104-2320-B-182-030, MOST
   105-2320-B-182-037, MOST104-2314-B-182A-031, MOST 105-2314-B-182A-058];
   Chang Gung Memorial Hospital of Taiwan [CMRPG8C0952, CMRPG8D1012,
   CMRPG8D0452, CMRPG8C0562, CMRPG8D1032, CMRPG8D1022]
FX The authors would like to thank Mr. Kazumi Ogata (Oga Research, Inc.,
   Osaka, Japan) for donating DHL-HisZn; and Prof. Seigo Kitano for his
   thoughtful comments. This work was supported in part by grants from the
   Ministry of Science and Technology (MOST104-2314-B-182A-018 and MOST
   105-2314-B-182A-037 -MY2 to CL-C; MOST104-2320-B-182-030 and MOST
   105-2320-B-182-037 to TN; MOST104-2314-B-182A-031 and MOST
   105-2314-B-182A-058 to CC-C) and the Chang Gung Memorial Hospital
   (CMRPG8C0952 and CMRPG8D1012 to CL-C; CMRPG8D0452 to CC-C; CMRPG8C0562
   to TN; CMRPG8D1032 to KT-H; CMRPG8D1022 to KD-C) of Taiwan.
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NR 41
TC 9
Z9 9
U1 0
U2 5
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI PARIS
PA 23 RUE LINOIS, 75724 PARIS, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD DEC
PY 2016
VL 84
BP 1601
EP 1609
DI 10.1016/j.biopha.2016.10.066
PG 9
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA EF6JU
UT WOS:000390438100187
PM 27825800
DA 2025-06-11
ER

PT J
AU Dubois, V
   Laurent, MR
   Jardi, F
   Antonio, L
   Lemaire, K
   Goyvaerts, L
   Deldicque, L
   Carmeliet, G
   Decallonne, B
   Vanderschueren, D
   Claessens, F
AF Dubois, Vanessa
   Laurent, Michael R.
   Jardi, Ferran
   Antonio, Leen
   Lemaire, Katleen
   Goyvaerts, Lotte
   Deldicque, Louise
   Carmeliet, Geert
   Decallonne, Brigitte
   Vanderschueren, Dirk
   Claessens, Frank
TI Androgen Deficiency Exacerbates High-Fat Diet-Induced Metabolic
   Alterations in Male Mice
SO ENDOCRINOLOGY
LA English
DT Article
ID INSULIN-RESISTANCE; DEPRIVATION THERAPY; PLASMA ADIPONECTIN; HEPATIC
   STEATOSIS; ADIPOSE-TISSUE; RAT MODEL; TESTOSTERONE; RECEPTOR; MEN;
   KNOCKOUT
AB Androgen deficiency is associated with obesity, metabolic syndrome, and type 2 diabetes mellitus in men, but the mechanisms behind these associations remain unclear. In this study, we investigated the combined effects of androgen deficiency and high-fat diet (HFD) on body composition and glucose homeostasis in C57BL/6J male mice. Two models of androgen deficiency were used: orchidectomy (ORX) and androgen receptor knockout mice. Both models displayed higher adiposity and serum leptin levels upon HFD, whereas no differences were seen on a regular diet. Fat accumulation in HFD ORX animals was accompanied by increased sedentary behavior and occurred in spite of reduced food intake. HFD ORX mice showed white adipocyte hypertrophy, correlated with decreased mitochondrial content but not function as well as increased lipogenesis and decreased lipolysis suggested by the up-regulation of fatty acid synthase and the down-regulation of hormone-sensitive lipase. Both ORX and androgen receptor knockout exacerbated HFD-induced glucose intolerance by impairing insulin action in liver and skeletal muscle, as evidenced by the increased triglyceride and decreased glycogen content in these tissues. In addition, serum IL-1 beta levels were elevated, and pancreatic insulin secretion was impaired after ORX. Testosterone but not dihydrotestosterone supplementation restored the castration effects on body composition and glucose homeostasis. We conclude that sex steroid deficiency in combination with HFD exacerbates adiposity, insulin resistance, and beta-cell failure in 2 preclinical male mouse models. Our findings stress the importance of a healthy diet in a clinical context of androgen deficiency and may have implications for the prevention of metabolic alterations in hypogonadal men.
C1 [Dubois, Vanessa; Laurent, Michael R.; Antonio, Leen; Claessens, Frank] Katholieke Univ Leuven, Mol Endocrinol Lab, Dept Cellular & Mol Med, Campus Gasthuisberg O&N1 POB 901,Herestr 49, B-3000 Leuven, Belgium.
   [Laurent, Michael R.] Katholieke Univ Leuven, Gerontol & Geriatr, B-3000 Leuven, Belgium.
   [Jardi, Ferran; Antonio, Leen; Carmeliet, Geert; Decallonne, Brigitte; Vanderschueren, Dirk] Katholieke Univ Leuven, Clin & Expt Endocrinol, Dept Clin & Expt Med, B-3000 Leuven, Belgium.
   [Lemaire, Katleen; Goyvaerts, Lotte] Katholieke Univ Leuven, Gene Express Unit, Dept Cellular & Mol Med, B-3000 Leuven, Belgium.
   [Deldicque, Louise] Katholieke Univ Leuven, Exercise Physiol Res Grp, Dept Kinesiol, B-3000 Leuven, Belgium.
   [Deldicque, Louise] Catholic Univ Louvain, Inst Neurosci, B-1348 Louvain, Belgium.
C3 KU Leuven; KU Leuven; KU Leuven; KU Leuven; KU Leuven; Universite
   Catholique Louvain
RP Claessens, F (corresponding author), Katholieke Univ Leuven, Mol Endocrinol Lab, Dept Cellular & Mol Med, Campus Gasthuisberg O&N1 POB 901,Herestr 49, B-3000 Leuven, Belgium.
EM frank.claessens@med.kuleuven.be
RI jardi, ferran/LTE-4251-2024; Goyvaerts, Lotte/AAP-9125-2020; Dubois,
   Vanessa/ABF-9551-2021; Laurent, Michael/D-5748-2011; Antonio,
   Leen/T-1206-2018; Claessens, Frank/M-8565-2016
OI Jardi, Ferran/0000-0003-4468-6123; Laurent, Michael/0000-0001-9681-8330;
   Dubois, Vanessa/0000-0001-8894-2980; Antonio, Leen/0000-0002-1079-2860;
   Decallonne, Brigitte/0000-0003-4153-4757; vanderschueren,
   dirk/0000-0003-1395-0104; Claessens, Frank/0000-0002-8676-7709;
   Deldicque, Louise/0000-0003-3393-5278
FU KU Leuven Grant [GOA/15/017]; Research Foundation Flanders Grant
   [G.0858.11]
FX This work was supported by the KU Leuven Grant GOA/15/017 and the
   Research Foundation Flanders Grant G.0858.11.
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NR 56
TC 88
Z9 99
U1 0
U2 16
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0013-7227
EI 1945-7170
J9 ENDOCRINOLOGY
JI Endocrinology
PD FEB
PY 2016
VL 157
IS 2
BP 648
EP 665
DI 10.1210/en.2015-1713
PG 18
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA DD5LT
UT WOS:000369965900022
PM 26562264
OA Bronze
DA 2025-06-11
ER

PT J
AU Nansseu, JRN
   Noubiap, JJN
   Mengnjo, MK
   Aminde, LN
   Essouma, M
   Jingi, AM
   Bigna, JJR
AF Nansseu, Jobert Richie N.
   Noubiap, Jean Jacques N.
   Mengnjo, Michel K.
   Aminde, Leopold Ndemnge
   Essouma, Mickael
   Jingi, Ahmadou M.
   Bigna, Jean Joel R.
TI The highly neglected burden of resistant hypertension in Africa: a
   systematic review and meta-analysis
SO BMJ OPEN
LA English
DT Review
ID SUB-SAHARAN AFRICA; PREVALENCE; AWARENESS; APPARENT; ADULTS; MIDDLE
AB Objective: The hypertension epidemic in Africa collectively with very low rates of blood pressure control may predict an incremented prevalence of resistant hypertension (RH) across the continent. The aim of this study was to determine the prevalence of RH and associated risk factors in Africa.
   Data sources: We conducted a comprehensive search of electronic databases (PubMed, EMBASE, Africa Wide Information and Africa Index Medicus) completed by manual search of articles, regardless of language or publication date.
   Methods: We included studies which have reported the prevalence and/or risk factors for RH in Africa from inception to 19 May 2016. Forest plots were drawn to visualise the combined prevalence of RH and extent of statistical heterogeneity between studies.
   Results: Out of 259 retrieved studies, only 5 from Cameroon, Nigeria, Burkina Faso, Lesotho and Algeria with a total population of 4 068 patients were finally included in this review. There was no study from the Eastern part of Africa. Though the definition of RH was not similar across studies, its prevalence was respectively 11.7%, 4.9%, 14.6%, 14.3% and 19.0%, with an overall pooled prevalence of 12.1% (95% CI 8.0% to 17.7%). Potential risk factors were: noncompliance to treatment, ageing, male sex, dyslipidaemia, metabolic syndrome, previous cardiovascular events, physical inactivity and stress, but not excessive salt intake, alcohol and coffee ingestions. Moreover, diabetes, smoking, obesity and renal insufficiency yielded discrepant results.
   Conclusions: There is a huge dearth of research on the epidemiology of RH in Africa. Thereby, an extensive study of RH prevalence and risk factors is still largely warranted to curtail the high and continuously increasing burden of hypertension across Africa.
C1 [Nansseu, Jobert Richie N.] Univ Yaounde I, Fac Med & Biomed Sci, Dept Publ Hlth, Yaounde, Cameroon.
   [Nansseu, Jobert Richie N.] Chantal Biya Fdn, Mother & Child Ctr, Sickle Cell Dis Unit, Yaounde, Cameroon.
   [Noubiap, Jean Jacques N.] Groote Schuur Hosp, Dept Med, Cape Town, South Africa.
   [Noubiap, Jean Jacques N.] Univ Cape Town, Cape Town, South Africa.
   [Noubiap, Jean Jacques N.] Med Diagnost Ctr, Yaounde, Cameroon.
   [Mengnjo, Michel K.; Jingi, Ahmadou M.] Univ Yaounde I, Fac Med & Biomed Sci, Dept Internal Med & Specialties, Yaounde, Cameroon.
   [Aminde, Leopold Ndemnge] Univ Queensland, Sch Publ Hlth, Fac Med & Biomed Sci, Brisbane, Qld, Australia.
   [Aminde, Leopold Ndemnge] Noncommunicable Dis Unit, Clin Res Educ Networking & Consultancy, Douala, Cameroon.
   [Essouma, Mickael] Sangmelima Reference Hosp, Div Med, Sangmelima, Cameroon.
   [Bigna, Jean Joel R.] Ctr Pasteur Cameroon, Dept Epidemiol & Publ Hlth, Yaounde, Cameroon.
C3 University of Yaounde I; University of Cape Town; University of Cape
   Town; University of Yaounde I; University of Queensland
RP Nansseu, JRN (corresponding author), Univ Yaounde I, Fac Med & Biomed Sci, Dept Publ Hlth, Yaounde, Cameroon.; Nansseu, JRN (corresponding author), Chantal Biya Fdn, Mother & Child Ctr, Sickle Cell Dis Unit, Yaounde, Cameroon.
EM jobertrichie_nansseu@yahoo.fr
RI Moradi, Ghobad/R-1267-2016; Essouma, Mickael/R-7710-2018; AMINDE,
   Leopold/K-5684-2019; Bigna, Jean Joel/A-1781-2015
OI Essouma, Mickael/0000-0003-2364-5517; Bigna, Jean
   Joel/0000-0001-8018-6279; Noubiap, Jean Jacques/0000-0002-7722-9757;
   MENGNJO, MICHEL KARNGONG/0009-0009-7610-6585
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NR 35
TC 29
Z9 29
U1 0
U2 1
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2044-6055
J9 BMJ OPEN
JI BMJ Open
PY 2016
VL 6
IS 9
AR e011452
DI 10.1136/bmjopen-2016-011452
PG 9
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA EG8JL
UT WOS:000391302900140
PM 27650760
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Zhang, YJ
   Bao, MW
   Dai, MY
   Wang, X
   He, WB
   Tan, TT
   Lin, DD
   Wang, W
   Wen, Y
   Zhang, R
AF Zhang, Yijie
   Bao, Mingwei
   Dai, Mingyan
   Wang, Xin
   He, Wenbo
   Tan, Tuantuan
   Lin, Dandan
   Wang, Wei
   Wen, Ying
   Zhang, Rui
TI Cardiospecific CD36 suppression by lentivirus-mediated RNA interference
   prevents cardiac hypertrophy and systolic dysfunction in high-fat-diet
   induced obese mice
SO CARDIOVASCULAR DIABETOLOGY
LA English
DT Article
DE Obesity; Cardiomyopathy; CD36; RNA interference; Lipotoxicity
ID OXIDATIVE STRESS; METABOLIC SYNDROME; HEART-DISEASE; MITOCHONDRIAL;
   CARDIOMYOPATHY; LIPOTOXICITY; TRANSPORTERS; INCREASES; PRESSURE;
   FIBROSIS
AB Background: Fatty acid (FA) catabolism abnormality has been proved to play an important role in obesity-related cardiomyopathy. We hypothesized that cardiospecific suppression of CD36, the predominant membrane FA transporter, would protect against obesity-related cardiomyopathy.
   Methods: Four-wk-old male C57BL/6 J mice were fed with either high-fat-diet (HFD) or control-normal-diet for 2 wk. Then they were subjected to intramyocardial injection with recombinant lentiviral vectors containing short hairpin RNAs to selectively downregulate the expression of either cardiac CD36 or irrelevant gene by RNA interference. After a 10-wk continuation of the diet, biochemical, functional, morphological, histological, metabolic and molecular profiles were assessed.
   Results: HFD administration elicited obesity, cardiac hypertrophy and systolic dysfunction accompanied with elevated serum levels of blood urea nitrogen (BUN), creatinine, fasting serum glucose (FSG), total cholesterol (TC) and triglyceride. Additionally, HFD consumption promoted lipid accumulation and reactive oxygen species (ROS) generation in the cardiomyocytes. Cardiospecific CD36 inhibition protected against HFD induced cardiac remodeling by decreasing heart/body weight ratio, increasing left ventricular (LV) ejection fraction and fractional shortening as well as normalizing LV diameter, without influencing body weight gain. Inhibition of cardiac CD36 also mitigated obesity induced alteration in BUN, creatinine and triglyceride, but had no effect on FSG or TC. Moreover, cardiospecific CD36 deficiency corrected myocardial lipid overaccumulation and intracellular ROS overproduction that were induced by HFD feeding.
   Conclusions: Cardiospecific CD36 inhibition protects against the aggravation of cardiac functional and morphological changes associated with HFD induced obesity. CD36 represents a potential therapeutic target for obesity cardiomyopathy.
C1 [Zhang, Yijie; Bao, Mingwei; Dai, Mingyan; Wang, Xin; He, Wenbo; Wen, Ying] Wuhan Univ, Renmin Hosp, Dept Cardiol, Wuhan 430060, Peoples R China.
   [Zhang, Yijie; Bao, Mingwei; Dai, Mingyan; Wang, Xin; He, Wenbo; Wen, Ying; Zhang, Rui] Wuhan Univ, Cardiovasc Res Inst, Wuhan 430060, Peoples R China.
   [Zhang, Yijie] Wuhan Univ, Renmin Hosp, Cent Lab, Wuhan 430060, Peoples R China.
   [Tan, Tuantuan] Wuhan Univ, Renmin Hosp, Dept Ultrasonog, Wuhan 430060, Peoples R China.
   [Lin, Dandan] Wuhan Univ, Renmin Hosp, Dept Oncol, Wuhan 430060, Peoples R China.
   [Wang, Wei] Wuhan Univ, Renmin Hosp, Dept Thorac Surg, Wuhan 430060, Peoples R China.
C3 Wuhan University; Wuhan University; Wuhan University; Wuhan University;
   Wuhan University; Wuhan University
RP Bao, MW (corresponding author), Wuhan Univ, Renmin Hosp, Dept Cardiol, 238 Jiefang Rd, Wuhan 430060, Peoples R China.
EM mbao@whu.edu.cn
RI Lin, Dandan/GRJ-2233-2022; Zhang, Rui/ABE-5542-2021; wang, wang
   wei/GRX-6697-2022
FU Natural Science Foundation of Hubei Province, China [2012FFB04332];
   Scientific Research Starting Foundation for Returned Overseas Chinese
   Scholars, Ministry of Education, China [2011508]; Fundamental Research
   Funds for the Central Universities, China [2042014kf0172]
FX This study was supported by the grants from the Natural Science
   Foundation of Hubei Province, China (No. 2012FFB04332); the Scientific
   Research Starting Foundation for Returned Overseas Chinese Scholars,
   Ministry of Education, China (No. 2011508); and the Fundamental Research
   Funds for the Central Universities, China (No. 2042014kf0172).
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NR 48
TC 26
Z9 27
U1 0
U2 16
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1475-2840
J9 CARDIOVASC DIABETOL
JI Cardiovasc. Diabetol.
PD JUN 3
PY 2015
VL 14
AR 69
DI 10.1186/s12933-015-0234-z
PG 12
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism
GA CK0NE
UT WOS:000355901100001
PM 26036798
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Ben Slama, F
   Jridi, N
   Ben Rayana, MC
   Trimeche, A
   Hsairi, M
   Belhadj, O
AF Ben Slama, Fethi
   Jridi, Nahawand
   Ben Rayana, Mohamed Chiheb
   Trimeche, Abdelmagid
   Hsairi, Mohamed
   Belhadj, Omrane
TI Plasma levels of leptin and ghrelin and their correlation with BMI, and
   circulating lipids and glucose in obese Tunisian women
SO ASIAN BIOMEDICINE
LA English
DT Article
DE BMI; ghrelin; leptin; lipids; obesity
ID INSULIN-RESISTANCE; METABOLIC SYNDROME; OXIDATIVE STRESS; BODY-MASS;
   ADIPONECTIN; DENSITY; CHOLESTEROL; GENDER
AB Background: A National Survey on the Effect of Nutrition conducted in 1996-1997 showed a 14% overall prevalence of obesity in Tunisia with a female predominance. Leptin and ghrelin play crucial roles in regulating body weight and energy balance. Leptin, an anorectic hormone, and ghrelin, an orexigenic hormone, appear to interact with glucose and lipid metabolism.
   Objectives: To determine the circulating levels of ghrelin and leptin in obese Tunisian women and to investigate the correlations of these hormones with body mass index (BMI), and circulating lipids and glucose.
   Methods: Forty obese women were recruited from patients in the "C" Unit of the National Institute of Nutrition and Food Technology. Twenty normal women were recruited as controls. Plasma levels of the studied variables were measured in patients from both groups and findings were analyzed.
   Results: Circulating levels of leptin were significantly higher, while high-density lipoprotein (HDL)-cholesterol and ghrelin levels were significantly lower in the obese women. In the obese women, significant positive correlations were found between circulating levels of leptin and low-density lipoprotein (LDL)-cholesterol, BMI, and glucose; and ghrelin and HDL-cholesterol. Significant negative correlations were found between circulating levels of leptin and HDL-cholesterol and ghrelin; and ghrelin and leptin, LDL-cholesterol, BMI, and glucose. Multivariate analysis revealed that ghrelin was significantly associated with HDL-cholesterol, LDL-cholesterol, and blood glucose.
   Conclusions: The significant negative correlation between leptin and ghrelin suggests that these two hormones may be antagonistic. Increased levels of ghrelin are correlated with decreased circulating levels of HDL-cholesterol and increased levels of LDL-cholesterol.
C1 [Ben Slama, Fethi; Hsairi, Mohamed] Natl Inst Publ Hlth INSP, Minist Publ Hlth, Tunis, Tunisia.
   [Jridi, Nahawand] Univ Monastir, Fac Pharm, Monastir, Tunisia.
   [Ben Rayana, Mohamed Chiheb; Trimeche, Abdelmagid] Natl Inst Nutr & Food Technol INNTA, Minist Publ Hlth, Tunis, Tunisia.
   [Belhadj, Omrane] Tunis El Manar Univ, Biochem & Biotechnol Lab, Fac Sci Tunis, Tunis, Tunisia.
C3 Universite de Monastir; Universite de Tunis-El-Manar; Institut National
   de Nutrition Technologie Alimentaire; Universite de Tunis-El-Manar;
   Faculte des Sciences de Tunis (FST)
RP Ben Slama, F (corresponding author), Natl Inst Publ Hlth, Blvd Hedi Saidi, Tunis 1005, Tunisia.
EM fethi.benslama@rns.tn
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NR 40
TC 8
Z9 8
U1 0
U2 9
PU CHULALONGKORN UNIV, FAC MED
PI BANGKOK
PA CHULALONGKORN UNIV, FAC MED, 1873, RAMA 4, BANGKOK, 10330, THAILAND
SN 1905-7415
EI 1875-855X
J9 ASIAN BIOMED
JI Asian Biomed.
PD APR
PY 2015
VL 9
IS 2
BP 161
EP 168
DI 10.5372/1905-7415.0902.382
PG 8
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA CO2UD
UT WOS:000359011200006
OA hybrid
DA 2025-06-11
ER

PT J
AU Ryoo, JH
   Kim, SY
   Oh, CM
   Park, SK
   Kim, E
   Park, SJ
   Yu, JI
   Kim, MG
   Choi, YS
   Ko, TS
AF Ryoo, Jae-Hong
   Kim, Sun Yong
   Oh, Chang-Mo
   Park, Sung Keun
   Kim, Eugene
   Park, Se-Jin
   Yu, Jae In
   Kim, Min-Gi
   Choi, Yong-Sung
   Ko, Taeg Su
TI The incidental relationship between serum ferritin levels and
   hypertension
SO INTERNATIONAL JOURNAL OF CARDIOLOGY
LA English
DT Article
DE Ferritin; Hypertension
ID BLOOD-PRESSURE; METABOLIC SYNDROME; OXIDATIVE STRESS; KOREAN MEN;
   INSULIN; IRON; ASSOCIATION; DISEASE; PREVALENCE; POTASSIUM
AB Background and objective: Although several studies have shown an association between ferritin level and hypertension, only a few studies have investigated the longitudinal relationship between them. Thus, we evaluated the incidental risk for hypertension according to baseline ferritin level.
   Patients and methods: A total of 7104 healthy Korean men matched by a propensity score, who had participated in a medical health check-up program in 2005, were followed up from 2005 to 2010. They were divided into four groups according to baseline serum ferritin level (first quartile-fourth quartile). The incidence of hypertension was compared among the four groups, and the Cox-proportional hazard model was used to assess whether the development of hypertension was associated with higher baseline serum ferritin level.
   Results: A total of 1252 (17.6%) cases had newly developed hypertension during the 26,339.5 person-years of follow-up between 2006 and 2010. The adjusted hazard ratios (HRs) (95% confidence intervals, CIs) for incident hypertension were 1.00 (reference), 1.09 (0.91-1.30), 1.21 (1.01-1.45) and 1.28 (1.07-1.52), respectively (P for trend = 0.003) through the quartiles of serum ferritin levels, respectively, after adjusting for multiple con-founders. For the log-transformed serum ferritin levels as a continuous variable, adjusted HRs and 95% CIs for HTN were 1.15 (1.02-1.29).
   Conclusions: Elevated serum ferritin level was independently associated with the incidental risk for hypertension in Korean men. This finding suggests the value of elevated ferritin level as an early predictor of hypertension. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
C1 [Ryoo, Jae-Hong; Park, Sung Keun] Kyung Hee Univ, Dept Prevent Med, Sch Med, Seoul, South Korea.
   [Kim, Sun Yong; Park, Sung Keun] Sungkyunkwan Univ, Sch Med, Kangbuk Samsung Hosp, Total Healthcare Ctr, Seoul, South Korea.
   [Oh, Chang-Mo] Natl Canc Ctr, Korea Cent Canc Registry, Natl Canc Control Inst, Goyang, South Korea.
   [Kim, Eugene; Park, Se-Jin; Ko, Taeg Su] Sungkyunkwan Univ, Sch Med, Kangbuk Samsung Hosp, Dept Orthopaed Surg, Seoul, South Korea.
   [Yu, Jae In] Gachon Univ, Grad Sch, Dept Med Management, Inchon, South Korea.
   [Kim, Min-Gi] Dongguk Univ, Gyeongju Hosp, Dept Occupat & Environm Med, Gyeongsangbuk Do, South Korea.
   [Choi, Yong-Sung] Kyung Hee Univ, Dept Pediat, Sch Med, Seoul, South Korea.
C3 Kyung Hee University; Sungkyunkwan University (SKKU); Samsung Medical
   Center; National Cancer Center - Korea (NCC); Sungkyunkwan University
   (SKKU); Samsung Medical Center; Gachon University; Dongguk University;
   Kyung Hee University
RP Park, SK (corresponding author), Kangbuk Samsung Hosp, 78 Saemunan Gil, Seoul 110746, South Korea.
EM kkkmin7@hotmail.com
RI Choi, Yong-Sung/ABG-7840-2020; Kim, Sun-Yong/A-2198-2017; Kim,
   Ha-Jung/AGU-3492-2022
OI Ryoo, Jae-Hong/0000-0002-5232-1426; Park, Sung Keun/0000-0003-4703-9917
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NR 39
TC 19
Z9 22
U1 0
U2 2
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0167-5273
EI 1874-1754
J9 INT J CARDIOL
JI Int. J. Cardiol.
PD MAR 15
PY 2015
VL 183
BP 258
EP 262
DI 10.1016/j.ijcard.2014.10.152
PG 5
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA CE6DV
UT WOS:000351927700039
PM 25704911
DA 2025-06-11
ER

PT J
AU Coban, N
   Onat, A
   Yildirim, O
   Can, G
   Erginel-Unaltuna, N
AF Coban, Neslihan
   Onat, Altan
   Yildirim, Ozlem
   Can, Gunay
   Erginel-Unaltuna, Nihan
TI Oxidative stress-mediated (sex-specific) loss of protection against
   type-2 diabetes by macrophage migration inhibitory factor (MIF)-173G/C
   polymorphism
SO CLINICA CHIMICA ACTA
LA English
DT Article
DE MIF gene; Polymorphism; apoB; Glucose; Diabetes mellitus
ID AUGSBURG CASE-COHORT; FACTOR MIF; METABOLIC SYNDROME; ABDOMINAL OBESITY;
   CORONARY-DISEASE; RISK-FACTORS; FOLLOW-UP; GENE; ASSOCIATION; VARIANTS
AB Background: The archetypical yet atypical cytokine macrophage migration inhibitory factor (MIF) fulfills pleiotropic immune functions in inflammatory diseases. Evidence emerging from both expression and functional studies implicates MIF in various aspects of cardiovascular diseases. We aimed to determine the covariates of MIF -173G/C polymorphism and its influence on type-2 diabetes risk in a sample representative of middle-aged Turks.
   Methods: Randomly selected 2250 Turkish adults (mean age; 49.7 +/- 11.9, 48.5% male) were genotyped for -173G/C polymorphism using hybridization probes in Real-Time PCR LC480 device.
   Results: The MIF-173CC genotype prevailed in 3.7% in men and 2.9% in women. C-allele carriage was associated linearly with wider waist girth, independently of fasting glucose, and was further related to higher apolipoprotein B (apoB) (p < 0.05) in men, but not women. Logistic regression analysis showed the C-allele carriage to tend to predict new-onset diabetes (RR 1.51; [95% CI 0.98; 2.32]), additively to age and fasting glucose in men, but not in women. In contrast, risk for established (baseline) diabetes mellitus was lower (OR = 0.49, 95% CI 026-0.93, p = 0.03) in heterozygotes, after adjustment for atherogenic dyslipidemia and other confounders.
   Conclusion: MIF-173GC polymorphism independently contributes to abdominal obesity and is related to apoB concentrations apparently in men alone. Tendency of the - 173C-allele carriage to predict new-onset diabetes independently was also confined to men. These gender-modulated associations suggest novel gene-gender-environmental interactions originating from a proinflammatory state. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Coban, Neslihan; Yildirim, Ozlem; Erginel-Unaltuna, Nihan] Istanbul Univ, Inst Expt Med, Dept Genet, TR-34080 Istanbul, Turkey.
   [Onat, Altan] Istanbul Univ, Cerrahpasa Med Fac, Dept Cardiol, TR-34080 Istanbul, Turkey.
   [Can, Gunay] Istanbul Univ, Dept Publ Hlth, Cerrahpasa Med Fac, TR-34080 Istanbul, Turkey.
C3 Istanbul University; Istanbul University - Cerrahpasa; Istanbul
   University; Istanbul University - Cerrahpasa; Istanbul University
RP Coban, N (corresponding author), Istanbul Univ, Inst Expt Med, Dept Genet, Vakif Gureba Cad, TR-34080 Istanbul, Turkey.
EM neslic@istanbul.edu.tr; alt_onat@yahoo.com.tr;
   ozlm-yildirim@hotmail.com; alpincan@yahoo.fr; nihanerginel@yahoo.com
RI Can, Günay/AAB-1669-2020; Coban, Neslihan/AAB-8766-2020;
   Erginel-Unaltuna, Nihan/A-4885-2018
OI Erginel-Unaltuna, Nihan/0000-0003-0562-0455
FU Research Support Unit of Istanbul University [ACIP-34682]; TARF by the
   Turkish Society of Cardiology
FX This study was supported by The Research Support Unit of Istanbul
   University as the project no. ACIP-34682. We acknowledge the financial
   support of the TARF by the Turkish Society of Cardiology and several
   pharmaceutical companies, Istanbul, and the partial logistic support of
   the Turkish Ministry of Health.
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NR 36
TC 22
Z9 24
U1 0
U2 12
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0009-8981
EI 1873-3492
J9 CLIN CHIM ACTA
JI Clin. Chim. Acta
PD JAN 1
PY 2015
VL 438
BP 1
EP 6
DI 10.1016/j.cca.2014.07.037
PG 6
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA AX0AT
UT WOS:000346616800001
PM 25108206
DA 2025-06-11
ER

PT J
AU Goyal, SN
   Haiderali, S
   Reddy, MN
   Arya, DS
   Patil, CR
AF Goyal, Sameer N.
   Haiderali, Shaikh
   Reddy, Navya M.
   Arya, Dharamvir Singh
   Patil, Chandragouda R.
TI Prediabetes: grounds of pitfall signalling alteration for cardiovascular
   disease
SO RSC ADVANCES
LA English
DT Review
ID MYOCARDIAL ISCHEMIA-REPERFUSION; ENDOTHELIAL DYSFUNCTION; NATRIURETIC
   PEPTIDE; PI3K/AKT PATHWAY; ANGIOTENSIN-II; METABOLIC SYNDROME; OXIDATIVE
   STRESS; INSULIN; VASOCONSTRICTION; MECHANISMS
AB Impaired glucose metabolism either in prediabetes or diabetes mellitus is one of the detrimental root causes of premature mortality throughout the world. Uncontrolled prediabetes coincides with the induction of diabetic mellitus and associated cardiovascular diseases (CVDs). Needless to mention, impaired glucose metabolism, including impaired fasting glucose (IFG) and impaired glucose tolerance (IGT), have been known individually or in combination as the prediabetic stage but by itself it is not diabetes mellitus. Impaired beta-cell function, insulin resistance, increased level of free fatty acids, hyperinsulinemia and down-regulation of GLUT-4 are critical impairments during prediabetes. The vascular endothelium sustains the free flow of blood in vessels by normalizing vascular tone by releasing numerous endothelial-derived factors. However, in recent studies a marked impairment in endothelial-derived factors has been observed in prediabetes. Thus, the impaired endothelial-derived factors could make prediabetic patients more vulnerable to cardiovascular disease pathology. Nobel laureates, Robert Furchgott, Louis Ignarro and Ferid Murad (1998) discovered a novel signalling molecule, nitric oxide (NO), identified as an endothelium-derived relaxing factor. This imperative mediator has potent vasodilatory, anti-platelet, anti-proliferative, and anti-inflammatory actions in vessels. Endothelium-derived NO generation is mediated through the activation of PI3-K-Akt-eNOS-NO signalling pathways. Therefore, conspicuous destruction in PI3-K-Akt-eNOS-NO signalling has been revealed in prediabetes and renders individuals more susceptible to CVDs. Several research reports have defined prediabetes as a platform for diabetes mellitus and associated CVDs. But the molecular alteration during prediabetes is unclear; however, the signalling modulator may be an imperative issue and may open a prerequisite new vista for novel research. In this review, we have critically discussed the possible signalling alteration in prediabetes.
C1 [Goyal, Sameer N.; Haiderali, Shaikh; Reddy, Navya M.; Patil, Chandragouda R.] RC Patel Inst Pharmaceut Educ & Res, Dept Pharmacol, Cardiovasc Pharmacol Div, Dhule, Maharashtra, India.
   [Arya, Dharamvir Singh] All India Inst Med Sci, Dept Pharmacol, New Delhi 110029, India.
C3 All India Institute of Medical Sciences (AIIMS) New Delhi
RP Goyal, SN (corresponding author), RC Patel Inst Pharmaceut Educ & Res, Dept Pharmacol, Cardiovasc Pharmacol Div, Dhule, Maharashtra, India.
EM goyal.aiims@gmail.com
RI Patil, Chandragouda/J-2235-2012
OI Patil, Chandragouda/0000-0001-8401-1978; Goyal,
   sameer/0000-0002-5241-7049
FU Young Scientist Research Scheme of Science and Engineering Research
   Board (SERB), Department of Science and Technology, New Delhi, India
   [SB/YS/LS-114/2013]
FX The authors gratefully acknowledge the financial support received under
   Young Scientist Research Scheme (File no. SB/YS/LS-114/2013) of Science
   and Engineering Research Board (SERB), Department of Science and
   Technology, New Delhi, India.
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NR 79
TC 6
Z9 6
U1 0
U2 16
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2046-2069
J9 RSC ADV
JI RSC Adv.
PY 2014
VL 4
IS 102
BP 58272
EP 58279
DI 10.1039/c4ra10366a
PG 8
WC Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry
GA AU2PQ
UT WOS:000345460800023
DA 2025-06-11
ER

PT J
AU Perticone, F
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   Tassone, JE
   Perticone, M
   Pascale, A
   Sciacqua, A
   Sesti, G
AF Perticone, Francesco
   Maio, Raffaele
   Tassone, Joseph E.
   Perticone, Maria
   Pascale, Alessandra
   Sciacqua, Angela
   Sesti, Giorgio
TI Interaction between uric acid and endothelial dysfunction predicts new
   onset of diabetes in hypertensive patients
SO INTERNATIONAL JOURNAL OF CARDIOLOGY
LA English
DT Article
DE Uric acid; Endothelial dysfunction; Diabetes; Cardiovascular risk
   factors
ID MUSCLE-CELL-PROLIFERATION; C-REACTIVE PROTEIN; CARDIOVASCULAR RISK;
   METABOLIC SYNDROME; OXIDATIVE STRESS; DISEASE; EXPRESSION; GLUCOSE;
   HEART; HYPERURICEMIA
AB Background: Both uric acid and endothelial dysfunction are associated with new occurrence of type-2 diabetes but, at this moment, there is no evidence about a possible interaction between them.
   We tested, in untreated hypertensive patients, without clinical evidence of vascular damage, the hypothesis that serum uric acid and endothelial dysfunction may interact in predicting new diabetes.
   Methods: In 500 uncomplicated hypertensive non diabetic (ADA criteria) patients we evaluated endothelial function, by strain-gauge plethysmography, and uric acid.
   Results: During the follow-up (median 87.1 months), there were 54 new cases of diabetes (1.8%/ year). On univariate analysis, incident diabetes was inversely related with ACh-stimulated FBF (HR= 0.65, 95% CI= 0.52-0.82; Pb<0.001) and directly with serum CRP (HR= 1.22, 95% CI= 1.09-1.37; P<0.001), HOMA-index (HR= 1.20, 95% CI= 1.05-1.37; P= 0.007), fasting insulin (HR= 1.05, 95% CI= 1.01-1.09; P= 0.006) and age (HR= 1.03, 95% CI= 1.00-1.05; P= 0.014). At multiple regression analysis, the interaction between ACh-stimulated FBF and uric acid resulted statistically significant. Similar results were observed for the interaction between FBF and CRP.
   Conclusions: Our data clearly demonstrate that the coexistence of both hyperuricemia and reduced endothelium-dependent vasodilation increases the risk to develop new diabetes in hypertensive patients. In addition, mild-inflammation seems to be the mediator of the interaction between endothelial dysfunction and uric acid. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
C1 [Perticone, Francesco; Maio, Raffaele; Tassone, Joseph E.; Perticone, Maria; Pascale, Alessandra; Sciacqua, Angela; Sesti, Giorgio] Magna Graecia Univ Catanzaro, Dept Expt & Clin Med G Salvatore, Catanzaro, Italy.
C3 Magna Graecia University of Catanzaro
RP Perticone, F (corresponding author), Dept Med Sperimentale & Clin, Campus Univ Germaneto,Vle Europa, I-88100 Catanzaro, Italy.
EM perticone@unicz.it
RI Perticone, Francesco/I-4260-2017; Sesti, Giorgio/B-1509-2012; Maio,
   Raffaele/A-2846-2015; Perticone, Maria/J-9965-2016
OI Maio, Raffaele/0000-0002-7290-9470; Sesti, Giorgio/0000-0002-1618-7688;
   Perticone, Maria/0000-0002-2456-1123
CR Al Suwaidi J, 2000, CIRCULATION, V101, P948, DOI 10.1161/01.CIR.101.9.948
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NR 39
TC 36
Z9 38
U1 0
U2 6
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0167-5273
EI 1874-1754
J9 INT J CARDIOL
JI Int. J. Cardiol.
PD JUL 15
PY 2013
VL 167
IS 1
BP 232
EP 236
DI 10.1016/j.ijcard.2011.12.065
PG 5
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 167AR
UT WOS:000320603100046
PM 22245480
DA 2025-06-11
ER

PT J
AU Leite, MLC
AF Leite, Maria Lea Correa
TI Fibrinogen, Hematocrit, Platelets in Mild Kidney Dysfunction and the
   Role of Uric Acid: An Italian Male Population Study
SO CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS
LA English
DT Article
DE epidemiology; glomerular filtration rate; uric acid; fibrinogen;
   platelets
ID MUSCLE-CELL-PROLIFERATION; MINOR RENAL DYSFUNCTION; C-REACTIVE PROTEIN;
   NITRIC-OXIDE; CARDIOVASCULAR-DISEASE; OXIDATIVE STRESS; ENDOTHELIAL
   DYSFUNCTION; METABOLIC SYNDROME; ALL-CAUSE; RISK
AB Aim: To examine the relationship between some blood parameters and mild kidney dysfunction. Participants and Methods: A total of 719 Italian men aged 42 to 74 years from a population-based survey carried out in the town of Bollate (Milan). General linear models were used to examine the variations in plasma fibrinogen, hematocrit, platelet counts, mean platelet volume, and uric acid across levels of kidney function (estimated on the basis of glomerular filtration rate [GFR]), adjusting for age, education, smoking, alcohol consumption, physical activity (evaluated as TV watching, engaging in sport practice, and walking/cycling), waist circumference, arm muscle area, high-density lipoprotein (HDL)-cholesterol, triglycerides, hypertension, diabetes, cardiovascular disease history, and nonsteroid anti-inflammatory, diuretic, and antihypertensive drug use. Results: Plasma fibrinogen and hematocrit levels increased, and platelet counts and mean platelet volume significantly decreased as GFR fell to < 80 or < 70 mL/min per 1.73 m(2); stratified analysis revealed an association with serum uric acid levels. Alterations compatible with an increased cardiovascular risk were particularly evident among the participants with higher uric acid levels, whereas those indicative of platelet dysfunction were found among participants with lower levels. Conclusions: Parameters affecting hemostasis and blood viscosity are altered when kidney function is only slightly reduced, and the patterns of these relationships seem to be influenced by the levels of serum uric acid, whose easy and inexpensive measurement could have prognostic value.
C1 CNR, Dept Epidemiol & Med Informat, Inst Biomed Technol, I-20090 Segrate, MI, Italy.
C3 Consiglio Nazionale delle Ricerche (CNR); Istituto di Tecnologie
   Biomediche (ITB-CNR)
RP Leite, MLC (corresponding author), CNR, Dept Epidemiol & Med Informat, Inst Biomed Technol, Via Fratelli Cervi 93, I-20090 Segrate, MI, Italy.
EM lea.correa@itb.cnr.it
RI Leite, Maria/F-5498-2013
FU Italian National Research Council
FX The author disclosed receipt of the following financial support for the
   research and/or authorship of this article from the Italian National
   Research Council in the framework of the project Prevention and Control
   of Disease Factors (FATMA).
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NR 79
TC 7
Z9 7
U1 0
U2 1
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1076-0296
EI 1938-2723
J9 CLIN APPL THROMB-HEM
JI Clin. Appl. Thromb.-Hemost.
PD FEB
PY 2011
VL 17
IS 1
BP 58
EP 65
DI 10.1177/1076029609347901
PG 8
WC Hematology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Hematology; Cardiovascular System & Cardiology
GA 704RW
UT WOS:000286071100008
PM 19825920
DA 2025-06-11
ER

PT J
AU Hermsdorff, HHM
   Puchau, B
   Zulet, MA
   Martínez, JA
AF Miranda Hermsdorff, Helen Hermana
   Puchau, Blanca
   Angeles Zulet, Maria
   Alfredo Martinez, Jose
TI Association of Body Fat Distribution with Proinflammatory Gene
   Expression in Peripheral Blood Mononuclear Cells from Young Adult
   Subjects
SO OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY
LA English
DT Article
ID SUBCUTANEOUS ADIPOSE-TISSUE; MESSENGER-RNA EXPRESSION; METABOLIC
   SYNDROME; OXIDATIVE STRESS; INSULIN-RESISTANCE; WEIGHT-LOSS; OBESITY;
   INFLAMMATION; PLASMA; POPULATION
AB Peripheral blood mononuclear cells (PBMC) measurements have proved useful in recent studies to discern peripheral biomarkers for common complex diseases and for understanding host responses to drugs and nutrition in personalized medicine. Despite the initial promising data from PBMC, there is little information, however, on inflammatory and immune gene regulation in the context of body fat distribution and metabolic features in healthy adults. We investigated the putative association of body fat distribution and related-metabolic features with mRNA levels of proinflammatory markers in PBMC. This study enrolled 136 healthy subjects (85 females/51 males; age: 21.5 +/- 2.5 years). Anthropometrical, clinical, metabolic, and proinflammatory variables were assessed with validated tools. Interestingly, in normal-weight subjects with lower truncal fat (TF) values, mRNA levels of ICAM1, IL1R1, IL6, and TNF-alpha in PBMC were lower (p<0.05), compared to normal-weight individuals with higher TF (>58.5/50.2% for men/women, respectively) and overweight/obese subjects [body mass index (BMI) >25 kg/m(2)]. After regression analyses were performed, individuals with the highest tertiles of TF and waist circumference displayed higher mRNA gene expressions as well as circulating proinflammatory (C-reactive protein and IL6) and metabolic (blood pressure, HOMA-IR, and LDL-c:HDL-c ratio) variables values (p<0.05), independent from gender. Our findings collectively suggest that the mRNA expression of certain proinflammatory markers in PBMC is associated with body fat distribution in healthy adult subjects, which in turn, was also related to metabolic features and plasma proinflammatory markers concentrations.
C1 [Miranda Hermsdorff, Helen Hermana; Puchau, Blanca; Angeles Zulet, Maria; Alfredo Martinez, Jose] Univ Navarra, Dept Nutr Food Sci Physiol & Toxicol, Pamplona 31008, Spain.
C3 University of Navarra
RP Martínez, JA (corresponding author), Univ Navarra, Dept Nutr Food Sci Physiol & Toxicol, C Irunlarrea 1, Pamplona 31008, Spain.
EM jalfmtz@unav.es
RI Hermsdorff, Helen Hermana Miranda/H-4525-2015; Zulet, M.
   Angeles/H-1317-2017; Martinez Hernandez, J Alfredo/K-8709-2014
OI Hermsdorff, Helen Hermana Miranda/0000-0002-4441-6572; Zulet, M.
   Angeles/0000-0002-3926-0892; Martinez Hernandez, J
   Alfredo/0000-0001-5218-6941
FU Health Department of the Government of Navarra [(22/2007]; Capes
   Foundation; Ministry of Education of Brazil; University of Navarra
   [375605-0]
FX This work was supported by Health Department of the Government of
   Navarra (22/2007) and by Linea Especial about Nutrition, Obesity and
   Health (University of Navarra LE/97). The Capes Foundation, Ministry of
   Education of Brazil as well as IBERCAJA and ADA fellowships scheme of
   the University of Navarra also provided research grants to H. H. M.
   Hermsdorff (no. 375605-0) and B. Puchau, respectively. We also wish to
   thank our physician Blanca E. Martinez de Morentin, our nurse Salome
   Perez, and our technician Veronica Ciaurriz, for excellent technical
   assistance.
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NR 54
TC 45
Z9 49
U1 1
U2 5
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1536-2310
EI 1557-8100
J9 OMICS
JI OMICS
PD JUN
PY 2010
VL 14
IS 3
BP 297
EP 307
DI 10.1089/omi.2009.0125
PG 11
WC Biotechnology & Applied Microbiology; Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Genetics & Heredity
GA 614HS
UT WOS:000279046800008
PM 20450441
DA 2025-06-11
ER

PT J
AU Smith, JJ
   Kenney, RD
   Gagne, DJ
   Frushour, BP
   Ladd, W
   Galonek, HL
   Israelian, K
   Song, J
   Razvadauskaite, G
   Lynch, AV
   Carney, DP
   Johnson, RJ
   Lavu, S
   Iffland, A
   Elliott, PJ
   Lambert, PD
   Elliston, KO
   Jirousek, MR
   Milne, JC
   Boss, O
AF Smith, Jesse J.
   Kenney, Renee Deehan
   Gagne, David J.
   Frushour, Brian P.
   Ladd, William
   Galonek, Heidi L.
   Israelian, Kristine
   Song, Jeffrey
   Razvadauskaite, Giedre
   Lynch, Amy V.
   Carney, David P.
   Johnson, Robin J.
   Lavu, Siva
   Iffland, Andre
   Elliott, Peter J.
   Lambert, Philip D.
   Elliston, Keith O.
   Jirousek, Michael R.
   Milne, Jill C.
   Boss, Olivier
TI Small molecule activators of SIRT1 replicate signaling pathways
   triggered by calorie restriction in vivo
SO BMC SYSTEMS BIOLOGY
LA English
DT Article
ID NECROSIS-FACTOR-ALPHA; FACTOR-KAPPA-B; METABOLIC SYNDROME; OXIDATIVE
   STRESS; CELL-SURVIVAL; TNF-ALPHA; LIFE-SPAN; INFLAMMATION; RECEPTOR;
   EXPRESSION
AB Background: Calorie restriction (CR) produces a number of health benefits and ameliorates diseases of aging such as type 2 diabetes. The components of the pathways downstream of CR may provide intervention points for developing therapeutics for treating diseases of aging. The NAD(+)-dependent protein deacetylase SIRT1 has been implicated as one of the key downstream regulators of CR in yeast, rodents, and humans. Small molecule activators of SIRT1 have been identified that exhibit efficacy in animal models of diseases typically associated with aging including type 2 diabetes. To identify molecular processes induced in the liver of mice treated with two structurally distinct SIRT1 activators, SIRT501 (formulated resveratrol) and SRT1720, for three days, we utilized a systems biology approach and applied Causal Network Modeling (CNM) on gene expression data to elucidate downstream effects of SIRT1 activation.
   Results: Here we demonstrate that SIRT1 activators recapitulate many of the molecular events downstream of CR in vivo, such as enhancing mitochondrial biogenesis, improving metabolic signaling pathways, and blunting pro-inflammatory pathways in mice fed a high fat, high calorie diet.
   Conclusion: CNM of gene expression data from mice treated with SRT501 or SRT1720 in combination with supporting in vitro and in vivo data demonstrates that SRT501 and SRT1720 produce a signaling profile that mirrors CR, improves glucose and insulin homeostasis, and acts via SIRT1 activation in vivo. Taken together these results are encouraging regarding the use of small molecule activators of SIRT1 for therapeutic intervention into type 2 diabetes, a strategy which is currently being investigated in multiple clinical trials.
C1 [Smith, Jesse J.; Gagne, David J.; Galonek, Heidi L.; Israelian, Kristine; Song, Jeffrey; Razvadauskaite, Giedre; Lynch, Amy V.; Carney, David P.; Lavu, Siva; Iffland, Andre; Elliott, Peter J.; Lambert, Philip D.; Jirousek, Michael R.; Milne, Jill C.; Boss, Olivier] Sirtris, Cambridge, MA 02139 USA.
   [Kenney, Renee Deehan; Frushour, Brian P.; Ladd, William; Johnson, Robin J.; Elliston, Keith O.] Genstruct Inc, Cambridge, MA USA.
RP Boss, O (corresponding author), Sirtris, 200 Technol Sq, Cambridge, MA 02139 USA.
EM jessejersmith@gmail.com; rkenney@genstruct.com;
   dgagne@sirtrispharma.com; bfrushour@genstruct.com; ladd@genstruct.com;
   hgalonek@sirtrispharma.com; kisraelian@sirtrispharma.com;
   jsong@sirtrispharma.com; nelia0505@yahoo.com; alynch@sirtrispharma.com;
   dcarney@sirtrispharma.com; rjohnson@genstruct.com;
   slavu@sirtrispharma.com; aiffland@sirtrispharma.com;
   pelliott@sirtrispharma.com; plambert@sirtrispharma.com;
   kelliston@genstruct.com; mjirousek@msn.com; jillcmilne@yahoo.com;
   oboss@sirtrispharma.com
OI Elliston, Keith/0000-0002-9110-9233
FU GSK company
FX We would like to acknowledge Michelle C. Gordon, Scott A. Ribich and
   Christian Reich for critical reading of the manuscript. We would like to
   thank Jose Saavedra and Mario Gutierrez for laboratory operations
   support. Funding for this research effort was provided entirely by
   Sirtris, a GSK company.
CR [Anonymous], R LANG ENV STAT COMP
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NR 87
TC 185
Z9 217
U1 2
U2 15
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1752-0509
J9 BMC SYST BIOL
JI BMC Syst. Biol.
PD MAR 10
PY 2009
VL 3
AR 31
DI 10.1186/1752-0509-3-31
PG 14
WC Mathematical & Computational Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Mathematical & Computational Biology
GA 431NV
UT WOS:000265069300001
PM 19284563
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Giallauria, F
   Palomba, S
   Manguso, F
   Vitelli, A
   Maresca, L
   Tafuri, D
   Lombardi, G
   Colao, A
   Vigorito, C
   Orio, F
AF Giallauria, Francesco
   Palomba, Stefano
   Manguso, Francesco
   Vitelli, Alessandra
   Maresca, Luigi
   Tafuri, Domenico
   Lombardi, Gaetano
   Colao, Annamaria
   Vigorito, Carlo
   Orio, Francesco
TI Abnormal heart rate recovery after maximal cardiopulmonary exercise
   stress testing in young overweight women with polycystic ovary syndrome
SO CLINICAL ENDOCRINOLOGY
LA English
DT Article
ID CARDIOVASCULAR RISK; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   DIABETES-MELLITUS; MORTALITY; ASSOCIATION; DISEASE; PREDICTOR;
   POPULATION; GLUCOSE
AB Objective Heart rate recovery (HRR) is a measure derived from exercise test, defined as the fall in heart rate during the first minute after maximal exercise. Abnormal HRR is a measure of autonomic dysfunction associated with an increased mortality. This study was performed to evaluate the HRR in polycystic ovary syndrome (PCOS).
   Design Prospective controlled clinical study.
   Patients Seventy-five PCOS women compared to 75 healthy women matched for age (21.7 +/- 2.1 years vs. 21.9 +/- 1.8 years, respectively) 2 2 and body mass index (BMI) (29.0 +/- 2.6 kg/m(2) vs. 29.1 +/- 2.9 kg/m(2), respectively).
   Measurements Subjects were studied for their hormonal and metabolic profile, and underwent cardiopulmonary exercise test (CPX).
   Results PCOS women showed a significantly reduced HRR (12.9 +/- 1.8 vs. 20.4 +/- 3.1 beats/min, P < 0.001) compared to healthy controls, an impairment in maximal oxygen consumption (18.0 +/- 2.3 ml/kg/min vs. 29.3 +/- 3.9 ml/kg/min) and in oxygen consumption at anaerobic threshold (13.6 +/- 2.6 ml/kg/min vs. 24.2 +/- 3.0 ml/kg/min). In PCOS women, abnormal HRR was inversely correlated to BMI (r = -0.582, P < 0.001) and to the area under the curve for insulin (r = -0.596, P < 0.001).
   Conclusions Our data demonstrate an abnormal HRR after maximal CPX in young overweight PCOS patients, and that HRR should be investigated as a further potential marker of increased cardiovascular risk in PCOS.
C1 [Giallauria, Francesco; Vitelli, Alessandra; Maresca, Luigi; Vigorito, Carlo] Univ Naples Federico II, Dept Clin Cardiovasc & Immunol Sci, Cardiac Rehabil Unit, Naples, Italy.
   [Palomba, Stefano] Magna Graceia Univ Catanzaro Catanzaro, Unit Reprod Med & Surg, Catanzaro, Italy.
   [Lombardi, Gaetano; Colao, Annamaria; Orio, Francesco] Univ Naples Federico II, Gastroenterol Unit, Dept Mol & Clin Endorinol & Oncol, Naples, Italy.
   [Manguso, Francesco] Univ Naples Federico II, Gastroenterol Unit, Dept Clin Expt Med, Naples, Italy.
   [Tafuri, Domenico] Univ Parthenope Naples, Fac Exercise Sci, Chair Methods & Teaching Sport Activ, Naples, Italy.
   [Orio, Francesco] Univ Parthenope Naples, Fac Motor Sci, Dept Endocrinol, Naples, Italy.
C3 University of Naples Federico II; Magna Graecia University of Catanzaro;
   University of Naples Federico II; University of Naples Federico II;
   Parthenope University Naples; Parthenope University Naples
RP Orio, F (corresponding author), Univ Naples Pathenope, Fac Exercise Sci, Naples, Italy.
EM francescoorio@virgilio.it
RI Giallauria, Francesco/B-5681-2013; Manguso, Francesco/JXW-9856-2024;
   Colao, Annamaria/A-7671-2011
OI Tafuri, Domenico/0000-0002-5948-1414; Manguso,
   Francesco/0000-0002-9617-7892; Palomba, Stefano/0000-0003-2767-8295
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NR 37
TC 46
Z9 49
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0300-0664
EI 1365-2265
J9 CLIN ENDOCRINOL
JI Clin. Endocrinol.
PD JAN
PY 2008
VL 68
IS 1
BP 88
EP 93
DI 10.1111/j.1365-2265.2007.03004.x
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 253QN
UT WOS:000252532800015
PM 17803701
DA 2025-06-11
ER

PT J
AU Brunetti, K
   Catalani, E
   Del Quondam, S
   Romano, N
   Ceci, M
   Clerici, G
   Gordin, M
   Bianchini, G
   Brandolini, L
   Aramini, A
   Cervia, D
AF Brunetti, Kashi
   Catalani, Elisabetta
   Del Quondam, Simona
   Romano, Nicla
   Ceci, Marcello
   Clerici, Giuditta
   Gordin, Marianna
   Bianchini, Gianluca
   Brandolini, Laura
   Aramini, Andrea
   Cervia, Davide
TI A novel free fatty acid receptor agonist improving metabolic health in
   Drosophila models
SO PHARMACOLOGICAL RESEARCH
LA English
DT Article
DE Free fatty acid receptors; Metabolic dysfunctions; Hyperglycaemia;
   Hyperlipidaemia; Drosophila melanogaster; FFAR orthologues
ID INSULIN-RESISTANCE; DIABETES-MELLITUS; OXIDATIVE STRESS; OBESITY;
   MELANOGASTER; IDENTIFICATION; CONSUMPTION; MANAGEMENT; SECRETION;
   DISEASES
AB The development of synthetic modulators for human free fatty acid receptors (FFARs) has gained attention for addressing diabetes, metabolic syndrome, and dyslipidaemia. A new dual FFAR1 (GPR40) and FFAR4 (GPR120) agonist, DFL23916, was recently identified to improve glucose homeostasis, prompting investigations into its effects on metabolic disorders. This study assessed the selectivity and toxicity of DFL23916 in vitro and evaluated its effects in vivo using Drosophila melanogaster models of high-sugar (HSD) and high-fat diets (HFD). DFL23916 showed no off-target activities with no toxicity/hepatotoxicity in cultured cells. In adult HSD-fed flies with defective mobility, the oral administration of DFL23916 enhanced climbing speed in a concentration-dependent manner and reduced the high content of glucose and triglyceride levels alongside markers of insulin resistance. The compound did not affect viability and food intake of flies exposed to chronic overcaloric conditions but it inhibited the progressive weight gain. Similarly, larvae development remained unaffected by DFL23916, while it counteracted glucose and triglyceride elevation and reduced lipid droplet size caused by HSD and HFD. Finally, in silico analysis highlighted the relevance of evolutionary conserved Drosophila receptors in fatty acid sensing, suggesting putative candidates for DFL23916 binding. Collectively, these findings indicated the safe profile of DFL23916 and its efficacy in ameliorating hyperglycaemic and hyperlipidaemic features in overcaloric fed flies. Our results not only suggest that DFL23916 could be a potential candidate for further investigation in the context of metabolic disorders but also reinforce D. melanogaster as a valuable model for the preclinical evaluation of metabolic interventions, including FFAR-targeting strategies.
C1 [Brunetti, Kashi; Catalani, Elisabetta; Del Quondam, Simona; Cervia, Davide] Univ Tuscia, Dept Innovat Biol Agrofood & Forest Syst DIBAF, largo Univ, I-01100 Viterbo, Italy.
   [Romano, Nicla] Univ Studi Link, Dept Life Sci Hlth & Hlth Profess, Rome, Italy.
   [Ceci, Marcello] Univ Tuscia, Dept Ecol & Biol DEB, Viterbo, Italy.
   [Clerici, Giuditta] Politecn Milan, Dept Elect Informat & Biomed Engn, Milan, Italy.
   [Clerici, Giuditta; Gordin, Marianna] Human Technopole, Milan, Italy.
   [Bianchini, Gianluca; Brandolini, Laura; Aramini, Andrea] Dompe farmaceut SpA, Res & Early Dev, Laquila, Italy.
C3 Tuscia University; Tuscia University; Polytechnic University of Milan;
   Human Technopole; Dompe
RP Cervia, D (corresponding author), Univ Tuscia, Dept Innovat Biol Agrofood & Forest Syst DIBAF, largo Univ, I-01100 Viterbo, Italy.
EM d.cervia@unitus.it
RI catalani, elisabetta/AAH-9247-2020
FU Italian Ministry of Enterprises [1410]
FX This work was supported by the national grant: "Fondo crescita
   sostenibile-no1410" (Italian Ministry of Enterprises DM 02/08/2019 and
   DD 02/10/2019) .
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NR 102
TC 0
Z9 0
U1 0
U2 0
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 1043-6618
EI 1096-1186
J9 PHARMACOL RES
JI Pharmacol. Res.
PD JUN
PY 2025
VL 216
AR 107769
DI 10.1016/j.phrs.2025.107769
PG 18
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 2UL8T
UT WOS:001491596900001
PM 40348099
OA hybrid
DA 2025-06-11
ER

PT J
AU Hu, YX
   Wang, YX
   Hong, HZ
   Chen, YX
   Zhou, QJ
   Zhu, GM
   Tang, JY
   Liu, WJ
   Wang, L
AF Hu, Yuxin
   Wang, Yaoxian
   Hong, Hanzhang
   Chen, Yexin
   Zhou, Qinjie
   Zhu, Gegongming
   Tang, Jingyi
   Liu, Weijing
   Wang, Lin
TI Global trends and prospects related to macrophage in chronic kidney
   disease: a bibliometric analysis
SO RENAL FAILURE
LA English
DT Review
DE Chronic kidney disease; macrophage; bibliometric analysis; metabolic
   syndrome; fibrosis; diabetic nephropathy
ID UNILATERAL URETERAL OBSTRUCTION; RENAL INFLAMMATION; INTERSTITIAL
   FIBROSIS; DENDRITIC CELLS; TGF-BETA; INJURY; MECHANISMS; EXPRESSION;
   CONTRIBUTES; INHIBITORS
AB Background and aimsMacrophages play a variety of widely concerned roles in the process of chronic kidney disease (CKD). To further understand the research hotspots and development trends regarding the relationship between macrophages and CKD, the role of macrophages in the occurrence and progression of CKD was summarized by bibliometrics in this study.Material and MethodsWe collected the studies relevant the role of macrophages in CKD from the Web of Science Core Collection, which included 1332 relevant studies from Jan 1st, 2004 to Jul 6th, 2023 in WoSCC. CiteSpace, biblioshiny in R, VOSviewer and SCImago Graphica Beta were used for bibliometric analysis and visualization.ResultsMonash University from Australia is the most productive institution, while China and the USA are most productive countries. Anders HJ is the most cited author. In terms of the number of co-citations, the top one was "Macrophages: versatile players in renal inflammation and fibrosis" by Patrick Ming-Kuen Tang, published in Nature Reviews Nephrology in 2019. Important keywords of this research topic include inflammation, dendritic cell, oxidative stress, NF-kappa B, tgf-beta, interstitial fibrosis, glomerulonephritis, diabetic nephropathy. Future research hotspots may include molecular mechanism, acute kidney injury, macrophage polarization, kidney fibrosis.ConclusionThis study provides a systematic review of the role of macrophages in CKD and speculates that future research hotspots. Previous studies have focused on the immune function of macrophages and atypia, and metabolic factors (especially iron metabolism within macrophages) have attracted the attention of researchers in recent years and are the forefront of recent research.
C1 [Hu, Yuxin; Wang, Yaoxian; Chen, Yexin; Zhou, Qinjie; Tang, Jingyi; Liu, Weijing; Wang, Lin] Beijing Univ Chinese Med, Dongzhimen Hosp, 5 Haiyangcang, Beijing, Peoples R China.
   [Hu, Yuxin; Hong, Hanzhang; Chen, Yexin; Zhou, Qinjie; Zhu, Gegongming; Tang, Jingyi] Beijing Univ Chinese Med, Beijing, Peoples R China.
   [Hu, Yuxin; Wang, Yaoxian; Tang, Jingyi; Wang, Lin] Beijing Univ Chinese Med, Renal Res Inst, Beijing, Peoples R China.
   [Wang, Yaoxian] Henan Univ Chinese Med, Zhengzhou, Henan, Peoples R China.
   [Liu, Weijing; Wang, Lin] Beijing Univ Chinese Med, Key Lab Chinese Internal Med, Minist Educ & Beijing, Dongzhimen Hosp, Beijing, Peoples R China.
C3 Beijing University of Chinese Medicine; Beijing University of Chinese
   Medicine; Beijing University of Chinese Medicine; Henan University of
   Traditional Chinese Medicine; Beijing University of Chinese Medicine;
   Ministry of Education - China
RP Wang, L (corresponding author), Beijing Univ Chinese Med, Dongzhimen Hosp, 5 Haiyangcang, Beijing, Peoples R China.
EM 20180941098@bucm.edu.cn
RI Tang, Jingyi/ITV-3871-2023
OI Hu, Yuxin/0009-0009-3426-3574
FU Beijing Municipal Natural Science Foundation [72444871]; National
   Natural Science Foundation of China [82071511731, zyyzdxk-2023260]
FX The author(s) declare financial support was received for the research,
   authorship, and/or publication of this article. This work was supported
   by the Beijing Municipal Natural Science Foundation [No.72444871;
   National Natural Science Foundation of China [No.82071511731; NATCM's
   Project of High-level Construction of Key TCM Disciplines-Beijing
   University of Chinese Medicine-Nephrology of traditional Chinese
   medicine [No.zyyzdxk-2023260].
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NR 93
TC 2
Z9 2
U1 10
U2 16
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0886-022X
EI 1525-6049
J9 RENAL FAILURE
JI Ren. Fail.
PD DEC 31
PY 2024
VL 46
IS 2
AR 2423846
DI 10.1080/0886022X.2024.2423846
PG 20
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA M9B1Z
UT WOS:001360404300001
PM 39572163
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Davis, NE
   Prasitlumkum, N
   Tan, NY
AF Davis, Nathaniel E.
   Prasitlumkum, Narut
   Tan, Nicholas Y.
TI Atrial Fibrillation and Cancer-Epidemiology, Mechanisms, and Management
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Review
DE atrial fibrillation; cancer; epidemiology; mechanisms; management
ID HEART RHYTHM ASSOCIATION; ADVERSE EVENTS; BREAST-CANCER; CARDIOVASCULAR
   TOXICITY; PRACTICE GUIDELINES; METABOLIC SYNDROME; CATHETER ABLATION;
   RADIATION-THERAPY; AMERICAN-COLLEGE; EUROPEAN-SOCIETY
AB Atrial fibrillation (AF) and cancer are increasingly recognized as interrelated conditions, with cancer patients showing elevated incidences of AF, and there is evidence that AF may sometimes precede cancer diagnoses. This comprehensive review investigates the epidemiology, pathophysiology, and management challenges associated with AF in cancer patients. Epidemiologically, several cancers are more closely related to increased rates of AF, including lung, colorectal, gastrointestinal, and hematologic malignancies. Mechanistically, both AF and cancer share pathophysiological pathways centered on inflammation, oxidative stress, and common cardiovascular risk factors, such as hypertension, obesity, and diabetes. The inflammatory microenvironment in tumors, marked by increased cytokines and growth factors, promotes atrial remodeling and AF susceptibility. Elevated reactive oxygen species (ROS) levels, driven by the metabolic demands of cancer, further contribute to atrial fibrosis and structural changes. Moreover, many anticancer treatments exacerbate AF risk. Management of AF in cancer patients presents many unique challenges and requires a multidisciplinary approach. Rate and rhythm control strategies are complicated by potential drug-drug interactions and limited data surrounding early implementation of rhythm control strategies in cancer patients. Interventional approaches such as catheter ablation, though effective in maintaining sinus rhythm, carry significant perioperative risk in patients with malignancy. Stroke prevention with anticoagulants is essential but requires cautious administration to avoid heightened bleeding risks, particularly in patients undergoing chemotherapy. Further, the limited applicability of standard risk stratification tools like CHA2DS2-VASc in this population complicate decisions regarding anticoagulation. This review highlights the bidirectional relationship between AF and cancer, the difficulties in management, and the critical need for further research in this field.
C1 [Davis, Nathaniel E.] Mayo Clin, Dept Internal Med, Rochester, MN 55905 USA.
   [Prasitlumkum, Narut; Tan, Nicholas Y.] Mayo Clin, Dept Cardiovasc Med, Rochester, MN 55905 USA.
C3 Mayo Clinic; Mayo Clinic
RP Prasitlumkum, N; Tan, NY (corresponding author), Mayo Clin, Dept Cardiovasc Med, Rochester, MN 55905 USA.
EM davis.nathaniel2@mayo.edu; prasitlumkum.narut@mayo.edu;
   tan.nicholas@mayo.edu
RI Prasitlumkum, Narut/O-4381-2019
OI Prasitlumkum, Narut/0000-0002-7956-0574; Tan,
   Nicholas/0000-0002-0365-9471
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NR 188
TC 0
Z9 0
U1 1
U2 1
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD DEC
PY 2024
VL 13
IS 24
AR 7753
DI 10.3390/jcm13247753
PG 20
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA Q8K9A
UT WOS:001387107400001
PM 39768676
OA gold
DA 2025-06-11
ER

PT J
AU Si, K
   Wei, C
   Xu, L
   Lv, W
   Dong, B
   Wang, Z
   Huang, Y
   Chen, Y
   Wang, Y
AF Si, K.
   Wei, C.
   Xu, L.
   Lv, W.
   Dong, B.
   Wang, Z.
   Huang, Y.
   Chen, Y.
   Wang, Y.
TI Association between serum free fatty acid levels and tophus in patients
   with gout: a cross-sectional study
SO CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
LA English
DT Article
DE free fatty acid; tophus; gout; urine pH
ID INSULIN-RESISTANCE; METABOLIC SYNDROME; PATHWAY; STRESS
AB Objective To explore the relationship between serum free fatty acid (FFA) and tophus in gout patients, and to investigate whether FFA increases the risk of tophus deposition by lowering urine pH.
   Methods A total of 595 patients with gout aged 18 to 80 were enrolled between June 2018 and August 2021. The subjects were divided into four groups according to FFA. Logistic regression was used to analyse the association between serum FFA and tophus. Receiver operating curves (ROC) were plotted to explore the predictive value of FFA on the occurrence of tophus.
   Results Accompanying the increase of FFA levels, the prevalence of tophus in groups Q3 and Q4 was significantly higher than in groups Q1 and Q2 (33.6%, 36.5% vs. 6.3%, 19.6%, p<0.001). According to the Spearman correlation, serum FFA levels were positively correlated with tophus while negatively with urine pH (p<0.001). FFA had a significant interaction with urine pH on tophus risk. Multivariate logistic regression showed that participants in Q2-Q4 had a higher OR of tophus than those in Q1 ( OR were 2.770, 5.878 and 7.958 in Q2-Q4, respectively). ROC showed the best cut-off value of serum FFA level in predicting the onset of tophus was 0.46 mmol/L. Serum FFA had a great discriminant ability to predict tophus.
   Conclusion High FFA levels are independently associated with tophus risk and FFA may promote tophi deposition by lowering urine pH. Serum FFA levels have a great screening value to identify tophus.
C1 [Si, K.; Wei, C.; Xu, L.; Lv, W.; Dong, B.; Wang, Z.; Huang, Y.; Chen, Y.; Wang, Y.] Qingdao Univ, Dept Endocrinol, Affiliated Hosp, Qingdao, Peoples R China.
C3 Qingdao University
RP Wang, Y (corresponding author), Qingdao Univ, Affiliated Hosp, Dept Endocrinol, 16 Jiangsu Rd, Qingdao 266003, Peoples R China.
EM wangyg1966@126.com
RI Si, Ke/HSL-4831-2023; Dong, Bingzi/KCY-0725-2024
OI Dong, Bingzi/0000-0003-2446-0725
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NR 34
TC 5
Z9 6
U1 1
U2 7
PU CLINICAL & EXPER RHEUMATOLOGY
PI PISA
PA VIA SANTA MARIA 31, 56126 PISA, ITALY
SN 0392-856X
EI 1593-098X
J9 CLIN EXP RHEUMATOL
JI Clin. Exp. Rheumatol.
PD MAR
PY 2023
VL 41
IS 3
BP 711
EP 717
DI 10.55563/clinexprheumatol/a3i566
PG 7
WC Rheumatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Rheumatology
GA Z4II1
UT WOS:001111723800021
PM 36305351
DA 2025-06-11
ER

PT J
AU Li, L
   Zhang, YW
   Luo, YD
   Meng, XH
   Pan, GX
   Zhang, H
   Li, YH
   Zhang, BL
AF Li, Lin
   Zhang, Yuwei
   Luo, Yudan
   Meng, Xianghui
   Pan, Guixiang
   Zhang, Han
   Li, Yuhong
   Zhang, Boli
TI The Molecular Basis of the Anti-Inflammatory Property of Astragaloside
   IV for the Treatment of Diabetes and Its Complications
SO DRUG DESIGN DEVELOPMENT AND THERAPY
LA English
DT Review
DE astragaloside IV; anti-inflammatory property; molecular basis; diabetes;
   complications
ID INDUCED PODOCYTE APOPTOSIS; KAPPA-B PATHWAY; HIGH GLUCOSE;
   DOWN-REGULATION; CELL APOPTOSIS; METABOLIC SYNDROME; UP-REGULATION;
   INHIBITION; RATS; INFLAMMATION
AB Astragali Radix is a significant traditional Chinese medication, and has a long history of clinical application in the treatment of diabetes mellitus (DM) and its complications. AS-IV is an active saponin isolated from it. Modern pharmacological study shows that AS-IV has anti-inflammatory, anti-oxidant and immunomodulatory activities. The popular inflammatory etiology of diabetes suggests that DM is a natural immune and low-grade inflammatory disease. Pharmacological intervention of the inflammatory response may provide promising and alternative approaches for the prevention and treatment of DM and its complications. Therefore, this article focuses on the potential of AS-IV in the treatment of DM from the perspective of an anti-inflammatory molecular basis. AS - IV plays a role by regulating a variety of anti-inflammatory pathways in multiple organs, tissues and target cells throughout the body. The blockade of the NF-kappa B inflammatory signaling pathway may be the central link of AS-IV's anti-inflammatory effect, resulting in a reduction in the tissue structure and function damage stimulated by inflammatory factors. In addition, AS-IV can delay the onset of DM and its complications by inhibiting inflammation-related oxidative stress, fibrosis and apoptosis signals. In conclusion, AS-IV has therapeutic prospects from the perspective of reducing the inflammation of DM and its complications. An in-depth study on the anti- inflammatory mechanism of AS-IV is of great significance for the effective use of Chinese herbal medicine and the promotion of its status and influence on the world.
C1 [Li, Lin; Zhang, Yuwei; Luo, Yudan; Meng, Xianghui; Zhang, Han; Li, Yuhong; Zhang, Boli] Tianjin Univ Tradit Chinese Med, Tianjin 301617, Peoples R China.
   [Li, Lin; Zhang, Han; Li, Yuhong] Tianjin Univ Tradit Chinese Med, Key Lab Pharmacol Tradit Chinese Med Formulae, Minist Educ, Tianjin 301617, Peoples R China.
   [Li, Lin; Zhang, Yuwei; Zhang, Han; Li, Yuhong; Zhang, Boli] Tianjin Univ Tradit Chinese Med, State Key Lab Component Based Chinese Med, Tianjin 301617, Peoples R China.
   [Pan, Guixiang] Tianjin Univ Tradit Chinese Med, Affiliated Hosp 2, Tianjin 300250, Peoples R China.
   [Li, Yuhong; Zhang, Boli] Tianjin Univ Tradit Chinese Med, 10 Poyang Lake Rd, Tianjin 301617, Peoples R China.
C3 Tianjin University of Traditional Chinese Medicine; Ministry of
   Education - China; Tianjin University of Traditional Chinese Medicine;
   Tianjin University of Traditional Chinese Medicine; Tianjin University
   of Traditional Chinese Medicine; Tianjin University of Traditional
   Chinese Medicine
RP Li, YH; Zhang, BL (corresponding author), Tianjin Univ Tradit Chinese Med, 10 Poyang Lake Rd, Tianjin 301617, Peoples R China.
EM yhltcm@126.com; zhangbolipr@163.com
RI Liu, Yuan/J-4453-2012; Li, M/AAG-4101-2019; LI, LIN/ABF-3496-2022
FU National Natural Science Foundation of China [81830112]; National Key
   Research and Development Project of China [2020YFA0708004]
FX Funding This study was supported by funds from the National Natural
   Science Foundation of China [81830112] , National Key Research and
   Development Project of China [2020YFA0708004] .
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NR 105
TC 20
Z9 20
U1 4
U2 26
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1177-8881
J9 DRUG DES DEV THER
JI Drug Des. Dev. Ther.
PY 2023
VL 17
BP 771
EP 790
DI 10.2147/DDDT.S399423
PG 20
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 9X1ZO
UT WOS:000949572600001
PM 36925998
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Ammendola, S
   d'Abusco, AS
AF Ammendola, Sergio
   Scotto d'Abusco, Anna
TI Nutraceuticals and the Network of Obesity Modulators
SO NUTRIENTS
LA English
DT Review
DE herbal nutrients; obesity; chronic inflammation; adipogenesis;
   lipogenesis; cell crosstalk
ID INSULIN-RESISTANCE; METABOLIC SYNDROME; OXIDATIVE STRESS;
   ANGELICA-KEISKEI; GUT MICROBIOTA; 3T3-L1; FAT; INFLAMMATION;
   MACROPHAGES; EXTRACT
AB Obesity is considered an increasingly widespread disease in the world population, regardless of age and gender. Genetic but also lifestyle-dependent causes have been identified. Nutrition and physical exercise play an important role, especially in non-genetic obesity. In a three-compartment model, the body is divided into fat mass, fat-free mass and water, and obesity can be considered a condition in which the percentage of total fat mass is in excess. People with a high BMI index or overweight use self-medications, such as food supplements or teas, with the aim to prevent or treat their problem. Unfortunately, there are several obesity modulators that act both on the pathways that promote adipogenesis and those that inhibit lipolysis. Moreover, these pathways involve different tissues and organs, so it is very difficult to identify anti-obesity substances. A network of factors and cells contributes to the accumulation of fat in completely different body districts. The identification of natural anti-obesity agents should consider this network, which we would like to call "obesosome". The nutrigenomic, nutrigenetic and epigenetic contribute to making the identification of active compounds very difficult. This narrative review aims to highlight nutraceuticals that, in vitro or in vivo, showed an anti-obesity activity or were found to be useful in the control of dysfunctions which are secondary to obesity. The results suggest that it is not possible to use a single compound to treat obesity, but that the studies have to be addressed towards the identification of mixtures of nutraceuticals.
C1 [Ammendola, Sergio] Ambiotec Sergio Ammendola, I-04012 Cisterna Latina, LT, Italy.
   [Scotto d'Abusco, Anna] Sapienza Univ Rome, Dept Biochem Sci, I-00185 Rome, Italy.
C3 Sapienza University Rome
RP Ammendola, S (corresponding author), Ambiotec Sergio Ammendola, I-04012 Cisterna Latina, LT, Italy.; d'Abusco, AS (corresponding author), Sapienza Univ Rome, Dept Biochem Sci, I-00185 Rome, Italy.
EM ammendola@ambiotec.it; anna.scottodabusco@uniroma1.it
OI scotto d'abusco, anna/0000-0002-3323-6015
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NR 124
TC 10
Z9 10
U1 4
U2 19
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD DEC
PY 2022
VL 14
IS 23
AR 5099
DI 10.3390/nu14235099
PG 18
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 6X1DP
UT WOS:000896162800001
PM 36501129
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Park, H
   Park, KY
   Kim, M
   Park, HK
   Hwang, HS
AF Park, Huiyul
   Park, Kye-Yeung
   Kim, Minki
   Park, Hoon-Ki
   Hwang, Hwan-Sik
TI Association between serum uric acid level and non-alcoholic fatty liver
   disease in Koreans
SO ASIAN BIOMEDICINE
LA English
DT Article
DE gastroenterology; hepatic fibrosis; hepatic steatosis; non-alcoholic
   fatty liver disease; serum uric acid
ID METABOLIC SYNDROME; RISK-FACTORS; HYPERURICEMIA; PROGRESSION;
   GENERATION; PREVALENCE; DIAGNOSIS; FIBROSIS; STRESS
AB Background The association between serum uric acid (SUA) levels and non-alcoholic fatty liver disease (NAFLD) is controversial. Objectives We compared the association of SUA levels with NAFLD, abnormal alanine transferase (ALT), and the degree of liver fibrosis to clarify the association of SUA levels with NAFLD. Methods We conducted a retrospective cross-sectional study. Adult patients who underwent a health check-up (N = 1,343) were included for analysis. Fatty liver was diagnosed by abdominal ultrasonography. The degree of liver fibrosis was determined using the NAFLD fibrosis score (NFS). Pearson correlation analysis showed a stronger correlation of SUA level with the fatty liver index (r = 0.40, P < 0.001) than the correlation with serum ALT level (r = 0.28, P < 0.001), or NFS (r = 0.018, P = 0.51). SUA levels in patients with NAFLD and an abnormal liver function test (LFT) result were significantly higher than levels in patients without NAFLD and abnormal LFT results. By contrast, there was no significant association of SUA level with NFS grade. When age, male sex, body mass index, the presence of hypertension, diabetic mellitus, and NAFLD, abnormality of ALT level, and SUA level were included in binary logistic regression to evaluate risk factors for elevated NFS grade, hyperuricemia was not significantly associated with NFS grade (OR = 0.94, P = 0.75). Conclusion Pearson correlation and logistic regression together indicated SUA level is more closely associated with hepatic steatosis than abnormal liver function test or hepatic fibrosis.
C1 [Park, Huiyul; Park, Kye-Yeung; Kim, Minki; Park, Hoon-Ki; Hwang, Hwan-Sik] Hanyang Univ, Dept Family Med, Coll Med, 222 Wangsimni Ro, Seoul 133791, South Korea.
C3 Hanyang University
RP Hwang, HS (corresponding author), Hanyang Univ, Dept Family Med, Coll Med, 222 Wangsimni Ro, Seoul 133791, South Korea.
EM fmhwang@hanyang.ac.kr
OI Park, Kye-Yeung/0000-0002-4668-4853; Park, Huiyul/0000-0001-5044-8688;
   Park, Hoon Ki/0000-0002-8242-0943
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NR 30
TC 2
Z9 4
U1 0
U2 8
PU WALTER DE GRUYTER GMBH
PI BERLIN
PA GENTHINER STRASSE 13, D-10785 BERLIN, GERMANY
SN 1905-7415
EI 1875-855X
J9 ASIAN BIOMED
JI Asian Biomed.
PD FEB 1
PY 2022
VL 16
IS 1
BP 15
EP 22
DI 10.2478/abm-2022-0003
PG 8
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA ZS4OC
UT WOS:000768445400003
PM 37551400
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Zai, WJ
   Chen, W
   Liu, HR
   Ju, DW
AF Zai, Wenjing
   Chen, Wei
   Liu, Hongrui
   Ju, Dianwen
TI Therapeutic Opportunities of IL-22 in Non-Alcoholic Fatty Liver Disease:
   From Molecular Mechanisms to Clinical Applications
SO BIOMEDICINES
LA English
DT Article
DE nonalcoholic fatty liver disease; interleukin-22; metabolic syndrome
ID DIET-INDUCED OBESITY; GUT MICROBIOTA; HEPATIC STEATOSIS; CELLS
   CONTRIBUTE; FUSION PROTEIN; HOST-DEFENSE; INTERLEUKIN-22; INFLAMMATION;
   CYTOKINES; IMMUNITY
AB Nonalcoholic fatty liver disease (NAFLD) represents one of the most common liver disorders and can progress into a series of liver diseases, including nonalcoholic steatohepatitis (NASH), fibrosis, cirrhosis, and even liver cancer. Interleukin-22 (IL-22), a member of the IL-10 family of cytokines, is predominantly produced by lymphocytes but acts exclusively on epithelial cells. IL-22 was proven to favor tissue protection and regeneration in multiple diseases. Emerging evidence suggests that IL-22 plays important protective functions against NAFLD by improving insulin sensitivity, modulating lipid metabolism, relieving oxidative and endoplasmic reticulum (ER) stress, and inhibiting apoptosis. By directly interacting with the heterodimeric IL-10R2 and IL-22R1 receptor complex on hepatocytes, IL-22 activates the Janus kinase 1 (JAK1)/ signal transducer and activator of transcription 3 (STAT3), c-Jun N-terminal kinase (JNK) and extracellular-signal regulated kinase (ERK) pathways to regulate the subsequent expression of genes involved in inflammation, metabolism, tissue repair, and regeneration, thus alleviating hepatitis and steatosis. However, due to the wide biodistribution of the IL-22 receptor and its proinflammatory effects, modifications such as targeted delivery of IL-22 expression and recombinant IL-22 fusion proteins to improve its efficacy while reducing systemic side effects should be taken for further clinical application. In this review, we summarized recent progress in understanding the physiological and pathological importance of the IL-22-IL-22R axis in NAFLD and the mechanisms of IL-22 in the protection of NAFLD and discussed the potential strategies to maneuver this specific cytokine for therapeutic applications for NAFLD.
C1 [Zai, Wenjing; Chen, Wei; Ju, Dianwen] Fudan Univ, Dept Biol Med, Sch Pharm, Shanghai 201203, Peoples R China.
   [Zai, Wenjing; Chen, Wei; Ju, Dianwen] Fudan Univ, Shanghai Engn Res Ctr Immunotherapeut, Sch Pharm, Shanghai 201203, Peoples R China.
   [Zai, Wenjing] Fudan Univ, Shanghai Med Coll, Sch Bas Med Sci, Key Lab Med Mol Virol MOE NHC CAMS, Shanghai 200032, Peoples R China.
   [Chen, Wei] Fudan Univ, Multiscale Res Inst Complex Syst, Shanghai 201203, Peoples R China.
   [Liu, Hongrui] Fudan Univ, Sch Pharm, Dept Pharmacol, Shanghai 201203, Peoples R China.
C3 Fudan University; Fudan University; Fudan University; Fudan University;
   Fudan University
RP Ju, DW (corresponding author), Fudan Univ, Dept Biol Med, Sch Pharm, Shanghai 201203, Peoples R China.; Ju, DW (corresponding author), Fudan Univ, Shanghai Engn Res Ctr Immunotherapeut, Sch Pharm, Shanghai 201203, Peoples R China.; Liu, HR (corresponding author), Fudan Univ, Sch Pharm, Dept Pharmacol, Shanghai 201203, Peoples R China.
EM 18111010065@fudan.edu.cn; w_chen16@fudan.edu.cn; liuhr@fudan.edu.cn;
   dianwenju@fudan.edu.cn
RI Liu, Hong-Rui/AAH-5073-2019
OI Liu, Hongrui/0000-0003-3975-8196
FU National Natural Science Foundation of China [81773620, 82073752];
   Shanghai Science and Technology Fund [20JC1411000, 20S11904700]
FX FundingOur work is by grants from the National Natural Science
   Foundation of China (Grant Nos. 81773620, 82073752) and the Shanghai
   Science and Technology Fund (20JC1411000 and 20S11904700).
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NR 102
TC 24
Z9 25
U1 1
U2 18
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2227-9059
J9 BIOMEDICINES
JI Biomedicines
PD DEC
PY 2021
VL 9
IS 12
AR 1912
DI 10.3390/biomedicines9121912
PG 16
WC Biochemistry & Molecular Biology; Medicine, Research & Experimental;
   Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Research & Experimental Medicine;
   Pharmacology & Pharmacy
GA XW9FW
UT WOS:000735916600001
PM 34944732
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Delitala, AP
   Scuteri, A
   Fiorillo, E
   Orrù, V
   Lakatta, EG
   Schlessinger, D
   Cucca, F
AF Delitala, Alessandro P.
   Scuteri, Angelo
   Fiorillo, Edoardo
   Orru, Valeria
   Lakatta, Edward G.
   Schlessinger, David
   Cucca, Francesco
TI Carotid Beta Stiffness Association with Thyroid Function
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Article
DE thyroxine; carotid beta stiffness; aging; carotid strain; thyroid
   hormone; heart rate
ID PULSE-WAVE VELOCITY; INTIMA-MEDIA THICKNESS; RESTING HEART-RATE;
   ARTERIAL STIFFNESS; BLOOD-PRESSURE; SUBCLINICAL HYPOTHYROIDISM;
   METABOLIC SYNDROME; RISK; ATHEROSCLEROSIS; AUTOIMMUNITY
AB Background: Thyroid hormone modulation of cardiovascular function has been associated with cardiovascular disease. Recent evidence suggests that free thyroxine (FT4) levels are associated with an increase in systemic arterial stiffness, but little is known about the effects of FT4 at the local level of the common carotid artery. beta-stiffness index is a local elastic parameter usually determined by carotid ultrasound imaging. Methods: We conducted a cross-sectional analysis in the ProgeNIA cohort, including 4846 subjects across a broad age range. For the purpose of this study, we excluded subjects with increased thyrotropin (TSH) levels and those treated with levothyroxine or thyrostatic. We assessed beta stiffness, strain, wall-lumen ratio, carotid cross-sectional area (CSA), and stress and flow in the right common carotid artery. We tested whether FT4, heart rate, and their interactions were associated with carotid parameters. Results: FT4 was positively and independently associated with beta stiffness index (beta = 0.026, p = 0.041), and had a negative association with strain (beta = -0.025, p = 0.009). After adding heart rate and the interaction between FT4 and heart rate to the model, FT4 was still associated with the beta stiffness index (beta = 0.186, p = 0.06), heart rate was positively associated with the stiffness index (beta = 0.389, p < 0.001) as well as their interaction (beta = 0.271, p = 0.007). Conclusion: This study suggests that higher FT4 levels increase arterial stiffness at the common carotid level, consistent with a detrimental effect on elastic arteries. The effect of FT4 is likely to be primarily attributable to its effect on heart rate.
C1 [Delitala, Alessandro P.; Scuteri, Angelo] Univ Sassari, Dept Med Surg & Expt Sci, I-07100 Sassari, Italy.
   [Delitala, Alessandro P.; Fiorillo, Edoardo; Orru, Valeria; Cucca, Francesco] Univ Monserrato, Ist Ric Genet & Biomed IRGB, Consiglio Nazl Ric, I-09042 Cagliari, Italy.
   [Lakatta, Edward G.] NIA, Lab Cardiovasc Sci, Intramural Res Program, NIH, Baltimore, MD 21224 USA.
   [Schlessinger, David] NIA, NIH, US Dept HHS, Baltimore, MD 21224 USA.
   [Cucca, Francesco] Univ Sassari, Dept Biomed Sci, I-07100 Sassari, Italy.
C3 University of Sassari; Consiglio Nazionale delle Ricerche (CNR);
   Istituto di Ricerca Genetica e Biomedica (IRGB-CNR); National Institutes
   of Health (NIH) - USA; NIH National Institute on Aging (NIA); National
   Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA);
   University of Sassari
RP Delitala, AP (corresponding author), Univ Sassari, Dept Med Surg & Expt Sci, I-07100 Sassari, Italy.; Delitala, AP (corresponding author), Univ Monserrato, Ist Ric Genet & Biomed IRGB, Consiglio Nazl Ric, I-09042 Cagliari, Italy.
EM aledelitala@uniss.it; ascuteri@uniss.it; edoardo.fiorillo@irgb.cnr.it;
   valeria.orru@irgb.cnr.it; lakattae@grc.nia.nih.gov;
   SchlessingerD@grc.nia.nih.gov; fcucca@uniss.it
RI Valeria, Orru/AAY-3805-2020; Lakatta, Edward/AAL-1447-2020; fiorillo,
   edoardo/AAY-3804-2020; Delitala, Alessandro/L-3194-2016
OI SCUTERI, ANGELO/0000-0003-4784-5441
FU NIH, National Institute on Aging [NO1-AG-1-2109]; National Institute on
   Aging [ZIAAG000675] Funding Source: NIH RePORTER
FX This work was supported in part by Contract NO1-AG-1-2109 from the NIH,
   National Institute on Aging.
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NR 46
TC 2
Z9 2
U1 0
U2 3
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD FEB
PY 2021
VL 10
IS 3
AR 420
DI 10.3390/jcm10030420
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA QD2EO
UT WOS:000615338600001
PM 33499200
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Hsu, MC
   Guo, BC
   Chen, CH
   Hu, PA
   Lee, TS
AF Hsu, Man Chen
   Guo, Bei Chia
   Chen, Chia Hui
   Hu, Po-An
   Lee, Tzong-Shyuan
TI Apigenin ameliorates hepatic lipid accumulation by activating the
   autophagy-mitochondria pathway
SO JOURNAL OF FOOD AND DRUG ANALYSIS
LA English
DT Article
DE Apigenin; Autophagy; Hepatic lipid metabolism; Mitochondria
ID FLAVONOID APIGENIN; METABOLIC SYNDROME; OXIDATIVE STRESS; CELL-DEATH;
   IN-VITRO; DYSFUNCTION; LIVER; INDUCTION; APOPTOSIS; DYNAMICS
AB Apigenin, a flavonoid isolated from plants, provides protection against non-alcoholic fatty liver disease. However, the mechanism by which apigenin decreases lipid accumulation in the liver is unclear. In this study, we investigated the molecular mechanism underlying the beneficial effect of apigenin on the hepatic deregulation of lipid metabolism. Oleic acid (OA)-induced lipid accumulation in human hepatoma cells (Huh7 cells) was used as an in vitro model. Western blot analysis was used for evaluating protein expression. Oil red O staining, Nile red staining, and conventional assay kits were used to assess the level of lipids. Immunocytochemistry was performed to observe mitochondrial morphology. Seahorse XF analyzer was used to measure mitochondrial bioenergetics. Treatment with OA induced lipid accumulation in Huh7 cells, which was attenuated by apigenin. Mechanistically, treatment with apigenin increased the expression of autophagy-related proteins including Beclin1, autophagy related gene 5 (ATG5), ATG7, and LC3II, and the formation of autophagolysosomes, leading to an increase in intracellular levels of fatty acids. Inhibition of autophagy by bafilomycin A1 or chloroquine abolished the protection of apigenin in OA-induced lipid accumulation. Apigenin up-regulated the protein expression related to the beta-oxidation pathway including acyl-CoA synthetase long chain family member 1, carnitine palmitoyltransferase 1 alpha, acyl-CoA oxidase 1, peroxisome proliferator activated receptor (PPAR) alpha, and PPAR gamma coactivator 1-alpha. Moreover, apigenin increased the mitochondrial network structure and mitochondrial function by increasing the protein expression related to the process of mitochondria fusion and mitochondrial function. Collectively, our findings suggest that apigenin ameliorates hepatic lipid accumulation by activating the autophagy-mitochondrial pathway.
C1 [Hsu, Man Chen; Guo, Bei Chia; Chen, Chia Hui; Hu, Po-An; Lee, Tzong-Shyuan] Natl Taiwan Univ, Coll Med, Grad Inst, Taipei 10051, Taiwan.
   [Hsu, Man Chen; Guo, Bei Chia; Chen, Chia Hui; Hu, Po-An; Lee, Tzong-Shyuan] Natl Taiwan Univ, Coll Med, Dept Physiol, Taipei 10051, Taiwan.
C3 National Taiwan University; National Taiwan University
RP Lee, TS (corresponding author), Natl Taiwan Univ, Coll Med, Grad Inst, Taipei 10051, Taiwan.; Lee, TS (corresponding author), Natl Taiwan Univ, Coll Med, Dept Physiol, Taipei 10051, Taiwan.
EM ntutslee@ntu.edu.tw
RI Lee, Tzong-Shyuan/AAE-5803-2020; Hu, Po-An/HKW-8872-2023
OI Hu, Po-An/0000-0002-4929-2353; LEE, TZONG-SHYUAN/0000-0002-9593-4062
FU Ministry of Science and Technology, Taiwan [106-2320-B-002-057-MY3,
   106-2320-B-002-056, 1062811-B-002-146, 108-2811-B-002-542, 108-2320-B002
   -032 -MY3]; National Taiwan University - Ministry of Science and
   Technology, Taiwan [108-2926-I-002-002-MY4]
FX This study was supported by grants from the Ministry of Science and
   Technology, Taiwan (106-2320-B-002-057-MY3, 106-2320-B-002-056,
   1062811-B-002-146; 108-2811-B-002-542 and 108-2320-B002 -032 -MY3). This
   article was subsidized for English editing by National Taiwan University
   under the Excellence Improvement Program for Doctoral Student (grant
   number 108-2926-I-002-002-MY4), sponsored by Ministry of Science and
   Technology, Taiwan. We thank the staff of the imaging core at the First
   Core Labs, National Taiwan University College of Medicine, for technical
   assistance.
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NR 52
TC 44
Z9 45
U1 3
U2 43
PU DIGITAL COMMONS BEPRESS
PI BERKELEY
PA 2100 MILVIA ST, STE 300, BERKELEY, CA 94704 USA
SN 1021-9498
J9 J FOOD DRUG ANAL
JI J. Food Drug Anal.
PY 2021
VL 29
IS 2
BP 240
EP 254
DI 10.38212/2224-6614.3269
PG 15
WC Food Science & Technology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Pharmacology & Pharmacy
GA SS4NB
UT WOS:000661729100004
PM 35696209
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Murai, Y
   Sasase, T
   Tadaki, H
   Heitaku, S
   Imagawa, N
   Yamada, T
   Ohta, T
AF Murai, Yasutaka
   Sasase, Tomohiko
   Tadaki, Hironobu
   Heitaku, Shiro
   Imagawa, Naoya
   Yamada, Takahisa
   Ohta, Takeshi
TI Analysis of haemodynamics and angiogenic response to ischaemia in the
   obese type 2 diabetic model Spontaneously Diabetic Torii
   Lepr<SUP>fa</SUP> (SDT fatty) rats
SO CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
LA English
DT Article
DE angiogenesis; coagulation; endothelial function; haemodynamics; hindlimb
   blood flow; ischaemia; peripheral artery disease; SDT fatty rats
ID NITRIC-OXIDE; OXIDATIVE-STRESS; DYSFUNCTION; DISEASE
AB Peripheral artery disease (PAD) is defined as peripheral blood flow impairment, especially in the legs, caused by atherosclerotic stenosis. The disease decreases quality of life because of intermittent claudication or necrosis of the leg. The hindlimb ischaemia model, in which ischaemia is induced by femoral artery ligation, is often utilized as a PAD model. In the hindlimb ischaemia model, nonmetabolic syndrome animals are mainly used. In this study, we investigated the usefulness of Spontaneously Diabetic Torii Lepr(fa) (SDT fatty) rats, a new model for obese type 2 diabetes, as a new PAD animal model. We found that hindlimb blood flow in SDT fatty rats was significantly lower than that in Sprague-Dawley (SD) rats under nonischaemic conditions. Furthermore, SDT fatty rats showed a significantly higher plasma nitrogen oxide level, shorter prothrombin time, and shorter activated partial thromboplastin time than SD rats. In addition, we found that the change in blood flow 7 days after induction of hindlimb ischaemia and the number of Von Willebrand factor-positive vessels in gastrocnemius muscles were significantly lower in SDT fatty rats than in SD rats. These results suggest that excess production of reactive oxygen species and coagulation activation could be involved in lower blood flow in non-ischaemic rats and that decreased angiogenesis could be involved in the poor recovery of blood flow in SDT fatty rats with hindlimb ischaemia. Taken together, our results suggest that SDT fatty rats might be useful as a new model for PAD with metabolic syndrome.
C1 [Murai, Yasutaka; Sasase, Tomohiko; Tadaki, Hironobu; Heitaku, Shiro; Imagawa, Naoya] Japan Tobacco Inc, Cent Pharmaceut Res Inst, 1-1 Murasaki Cho, Takatsuki, Osaka 5691125, Japan.
   [Murai, Yasutaka; Yamada, Takahisa] Niigata Univ, Fac Agr, Dept Agrobiol, Niigata, Japan.
   [Ohta, Takeshi] Kyoto Univ, Grad Sch Agr, Lab Anim Physiol & Funct Anat, Kitashirakawa, Kyoto, Japan.
C3 Japan Tobacco Inc.; Niigata University; Kyoto University
RP Murai, Y (corresponding author), Japan Tobacco Inc, Cent Pharmaceut Res Inst, 1-1 Murasaki Cho, Takatsuki, Osaka 5691125, Japan.; Murai, Y (corresponding author), Niigata Univ, Fac Agr, Dept Agrobiol, Niigata, Japan.
EM yasutaka.murai@jt.com
OI tai tian, yi/0000-0002-9573-3455; Sasase, Tomohiko/0000-0003-3387-6052
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NR 26
TC 2
Z9 2
U1 0
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0305-1870
EI 1440-1681
J9 CLIN EXP PHARMACOL P
JI Clin. Exp. Pharmacol. Physiol.
PD APR
PY 2020
VL 47
IS 4
BP 583
EP 590
DI 10.1111/1440-1681.13239
PG 8
WC Pharmacology & Pharmacy; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Physiology
GA KQ7GB
UT WOS:000517086500006
PM 31868944
DA 2025-06-11
ER

PT J
AU Mayneris-Perxachs, J
   Mousa, A
   Naderpoor, N
   Fernández-Real, JM
   de Courten, B
AF Mayneris-Perxachs, Jordi
   Mousa, Aya
   Naderpoor, Negar
   Fernandez-Real, Jose-Manuel
   de Courten, Barbora
TI Plasma Phospholipids with Long-Chain Polyunsaturated Fatty Acids and
   Dihydroceramides at the Crossroads of Iron Stores and Insulin Resistance
SO MOLECULAR NUTRITION & FOOD RESEARCH
LA English
DT Article
DE diabetes; ferritin; insulin resistance; iron; lipidomics
ID ENDOPLASMIC-RETICULUM STRESS; SERUM FERRITIN LEVELS; METABOLIC SYNDROME;
   PHOSPHATIDYLETHANOLAMINE; PHOSPHATIDYLCHOLINE; ADIPONECTIN;
   LYSOPHOSPHATIDYLINOSITOL; ASSOCIATION; HOMEOSTASIS; MECHANISMS
AB Scope Iron plays an important role in the pathogenesis of insulin resistance (IR) and type 2 diabetes. Recent studies suggest a role of specific lipids in the induction of IR, but the potential relationships between iron and lipid metabolites in relation to IR have not been explored. Therefore, the aim of the study is to evaluate the association among iron, IR, and the lipidome. Methods and results The plasma lipidome, IR, parameters of iron metabolism, and several cytokines and adipokines in 65 overweight/obese participants are measured. Measurements of IR correlate positively with ferritin, a measure of iron storage (r = 0.35, p = 0.005), and negatively with adiponectin (r = -0.30, p = 0.02). The serum ferritin/adiponectin ratio has a stronger association with IR (r = 0.41, p < 0.001). From multivariate analyses adjusted for age, sex, and BMI, several phospholipids containing long chain polyunsaturated fatty acids (PUFA) with 20-22 carbons (phosphatidylcholines, phosphatidylethanolamines, phosphatidylinositols, and a phosphatidylserine), are positively associated with ferritin and the ferritin/adiponectin ratio. Two dihydroceramides (Cer(18:0/22:0), Cer(18:0/24:0)) and several diglycerides and triglycerides, mainly comprised of C14:0, C16:0, C18:0, C18:1, and C18:2, also have positive correlations with ferritin and the ferritin/adiponectin ratio. Conclusions The positive associations between these lipid species and ferritin or the ferritin/adiponectin ratio suggest a potential crosstalk between iron and lipid metabolism in obesity and IR.
C1 [Mayneris-Perxachs, Jordi; Fernandez-Real, Jose-Manuel] Univ Girona, Hosp Girona Dr Josep Trueta, Dept Endocrinol Diabet & Nutr, Madrid, Spain.
   [Mayneris-Perxachs, Jordi; Fernandez-Real, Jose-Manuel] Inst Salud Carlos III, CIBERobn Pathophysiol Obes & Nutr, Madrid, Spain.
   [Mousa, Aya; Naderpoor, Negar; de Courten, Barbora] Monash Univ, Sch Publ Hlth & Prevent Med, Monash Ctr Hlth Res & Implementat, Melbourne, Vic, Australia.
C3 Universitat de Girona; Girona University Hospital Dr. Josep Trueta;
   CIBER - Centro de Investigacion Biomedica en Red; CIBEROBN; Instituto de
   Salud Carlos III; Monash University
RP Fernández-Real, JM (corresponding author), Univ Girona, Hosp Girona Dr Josep Trueta, Dept Endocrinol Diabet & Nutr, Madrid, Spain.; Fernández-Real, JM (corresponding author), Inst Salud Carlos III, CIBERobn Pathophysiol Obes & Nutr, Madrid, Spain.; de Courten, B (corresponding author), Monash Univ, Sch Publ Hlth & Prevent Med, Monash Ctr Hlth Res & Implementat, Melbourne, Vic, Australia.
EM jmfreal@idibgi.org; barbora.decourten@monash.edu
RI de Courten, Barbora/B-3308-2012; Fernández-Real, Jose
   Manuel/AGH-3599-2022; Mousa, Aya/AFU-5166-2022; Naderpoor,
   Negar/IUM-7706-2023; Mayneris-Perxachs, Jordi/AAG-7724-2020;
   MAYNERIS-PERXACHS, JORDI/B-2589-2018
OI Naderpoor, Negar/0000-0002-1738-3189; Mousa, Aya/0000-0002-7356-4523;
   Fernandez-Real, Jose Manuel/0000-0002-7442-9323; MAYNERIS-PERXACHS,
   JORDI/0000-0003-3788-3815
FU National Health and Medical Research Council (NHMRC) of Australia
   [APP1047897]; Instituto de Salud Carlos III (Madrid, Spain) through a
   Miguel Servet programme [CP18/00009]; Peter Doherty Biomedical Research
   Fellowship by NHMRC; National Heart Foundation [100 864]; NHMRC
FX The authors thank study participants as well as Ms. Josphin Johnson, Ms.
   Natalie Mellett, and Prof. Peter Meikle for conducting the laboratory
   lipidomics analyses and characterising the lipid species and classes.
   This work was supported by the National Health and Medical Research
   Council (NHMRC) of Australia (APP1047897). J.M.P. is funded by the
   Instituto de Salud Carlos III (Madrid, Spain) through a Miguel Servet
   programme (CP18/00009). A.M. is supported by a Peter Doherty Biomedical
   Research Fellowship provided by the NHMRC. N.N. is a Monash Partners
   Health Services Research Fellow. B.d.C. is supported by a National Heart
   Foundation Future Leader Fellowship (100 864) and is the recipient of
   theNHMRC grant that funded this study.
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NR 42
TC 5
Z9 5
U1 1
U2 11
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1613-4125
EI 1613-4133
J9 MOL NUTR FOOD RES
JI Mol. Nutr. Food Res.
PD MAR
PY 2020
VL 64
IS 5
AR 1901055
DI 10.1002/mnfr.201901055
EA JAN 2020
PG 11
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA KT5YK
UT WOS:000508911300001
PM 31945260
DA 2025-06-11
ER

PT J
AU Saiki, A
   Ohira, M
   Yamaguchi, T
   Nagayama, D
   Shimizu, N
   Shirai, K
   Tatsuno, I
AF Saiki, Atsuhito
   Ohira, Masahiro
   Yamaguchi, Takashi
   Nagayama, Daiji
   Shimizu, Naomi
   Shirai, Kohji
   Tatsuno, Ichiro
TI New Horizons of Arterial Stiffness Developed Using Cardio-Ankle Vascular
   Index (CAVI)
SO JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
LA English
DT Review
DE Cardio-ankle vascular index; Arterial stiffness; Stiffness parameter
   beta; Cardiovascular disease; Heart failure
ID PULSE-WAVE VELOCITY; CARDIOVASCULAR RISK-FACTORS; CALCIUM-CHANNEL
   BLOCKER; TYPE-2 DIABETIC-PATIENTS; SERUM URIC-ACID; BLOOD-PRESSURE;
   METABOLIC SYNDROME; NONINVASIVE ASSESSMENT; DIASTOLIC DYSFUNCTION;
   RECEPTOR BLOCKER
AB Arterial stiffness is recognized mainly as an indicator of arteriosclerosis and a predictor of cardiovascular events. Cardio-ankle vascular index (CAVI), which reflects arterial stiffness from the origin of the aorta to the ankle, was developed in 2004. An important feature of this index is the independency from blood pressure at the time of measurement. A large volume of clinical evidence obtained using CAVI has been reported. CAVI is high in patients with various atherosclerotic diseases including coronary artery disease and chronic kidney disease. Most coronary risk factors increase CAVI and their improvement reduces CAVI. Many prospective studies have investigated the association between CAVI and future cardiovascular disease (CVD), and proposed CAVI of 9 as the optimal cut-off value for predicting CVD. Research also shows that CAVI reflects afterload and left ventricular diastolic dysfunction in patients with heart failure. Furthermore, relatively acute changes in CAVI are observed under various pathophysiological conditions including mental stress, septic shock and congestive heart failure, and in pharmacological studies. CAVI seems to reflect not only structural stiffness but also functional stiffness involved in acute vascular functions. In 2016, Spronck and colleagues proposed a variant index CAVI(0), and claimed that CAVI(0) was truly independent of blood pressure while CAVI was not. This argument was settled, and the independence of CAVI from blood pressure was reaffirmed. In this review, we summarize the recently accumulated evidence of CAVI, focusing on the proposed cut-off values for CVD events, and suggest the development of new horizons of vascular function index using CAVI.
C1 [Saiki, Atsuhito; Ohira, Masahiro; Yamaguchi, Takashi; Shimizu, Naomi; Tatsuno, Ichiro] Toho Univ, Ctr Diabet Endocrine & Metab, Sakura Med Ctr, 564-1 Shimoshizu, Sakura, Chiba 2858741, Japan.
   [Nagayama, Daiji] Nagayama Clin, Nagayama, Tochigi, Japan.
   [Shirai, Kohji] Mihama Hosp, Dept Internal Med, Chiba, Japan.
C3 Toho University
RP Saiki, A (corresponding author), Toho Univ, Ctr Diabet Endocrine & Metab, Sakura Med Ctr, 564-1 Shimoshizu, Sakura, Chiba 2858741, Japan.
EM atsuhito156@sakura.med.toho-u.ac.jp
RI Nagayama, Daiji/AAS-4216-2020
OI yong shan, da er/0000-0001-6119-8012
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NR 127
TC 81
Z9 81
U1 1
U2 9
PU JAPAN ATHEROSCLEROSIS SOC
PI TOKYO
PA NICHINAI-KAIKAN B1, 3-28-8 HONGO BUNKYO-KU, TOKYO, 113-0033, JAPAN
SN 1340-3478
EI 1880-3873
J9 J ATHEROSCLER THROMB
JI J. Atheroscler. Thromb.
PY 2020
VL 27
IS 8
BP 732
EP 748
DI 10.5551/jat.RV17043
PG 17
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA MY8KI
UT WOS:000558665300002
PM 32595186
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Gerst, F
   Wagner, R
   Oquendo, MB
   Siegel-Axel, D
   Fritsche, A
   Heni, M
   Staiger, H
   Häring, HU
   Ullrich, S
AF Gerst, Felicia
   Wagner, Robert
   Oquendo, Morgana Barroso
   Siegel-Axel, Dorothea
   Fritsche, Andreas
   Heni, Martin
   Staiger, Harald
   Haering, Hans-Ulrich
   Ullrich, Susanne
TI What role do fat cells play in pancreatic tissue?
SO MOLECULAR METABOLISM
LA English
DT Review
DE Fatty pancreas; Adipocytes; Paracrine signalling; Insulin secretion;
   beta-cell mass; Type 2 diabetes mellitus (T2DM)
ID STIMULATED INSULIN-SECRETION; ENDOPLASMIC-RETICULUM STRESS; ACID-INDUCED
   APOPTOSIS; LONG-TERM EXPOSURE; BETA-CELL; ADIPOSE-TISSUE; METABOLIC
   SYNDROME; IN-VIVO; ALPHA-2-ADRENERGIC INHIBITION; INFLAMMATORY CYTOKINES
AB Background: It is now generally accepted that obesity is a major risk factor for type 2 diabetes mellitus (T2DM). Hepatic steatosis in particular, as well as visceral and ectopic fat accumulation within tissues, is associated with the development of the disease. We recently presented the first study on isolated human pancreatic adipocytes and their interaction with islets [Gerst, F., Wagner, R., Kaiser, G., Panse, M., Heni, M., Machann, J., et al., 2017. Metabolic crosstalk between fatty pancreas and fatty liver: effects on local inflammation and insulin secretion. Diabetologia 60(11): 2240-2251.]. The results indicate that the function of adipocytes depends on the overall metabolic status in humans which, in turn, differentially affects islet hormone release.
   Scope of Review: This review summarizes former and recent studies on factors derived from adipocytes and their effects on insulin-secreting beta-cells, with particular emphasis on the human pancreas. The adipocyte secretome is discussed with a special focus on its influence on insulin secretion, beta-cell survival and apoptotic beta-cell death.
   Major Conclusions: Human pancreatic adipocytes store lipids and release adipokines, metabolites, and pro-inflammatory molecules in response to the overall metabolic, humoral, and neuronal status. The differentially regulated adipocyte secretome impacts on endocrine function, i.e., insulin secretion, beta-cell survival and death which interferes with glycemic control. This review attempts to explain why the extent of pancreatic steatosis is associated with reduced insulin secretion in some studies but not in others. (C) 2019 The Authors. Published by Elsevier GmbH.
C1 [Gerst, Felicia; Wagner, Robert; Oquendo, Morgana Barroso; Siegel-Axel, Dorothea; Fritsche, Andreas; Heni, Martin; Staiger, Harald; Haering, Hans-Ulrich; Ullrich, Susanne] German Ctr Diabet Res DZD, Tubingen, Germany.
   [Gerst, Felicia; Wagner, Robert; Heni, Martin; Staiger, Harald; Haering, Hans-Ulrich; Ullrich, Susanne] Eberhard Karls Univ Tubingen, Helmholtz Ctr Munich, Inst Diabet Res & Metab Dis, Tubingen, Germany.
   [Wagner, Robert; Oquendo, Morgana Barroso; Siegel-Axel, Dorothea; Fritsche, Andreas; Heni, Martin; Haering, Hans-Ulrich] Univ Hosp Tubingen, Div Endocrinol Diabetol & Nephrol, Dept Internal Med 4, Tubingen, Germany.
   [Staiger, Harald] Eberhard Karls Univ Tubingen, Dept Pharm & Biochem, Inst Pharmaceut Sci, Tubingen, Germany.
C3 German Center for Diabetes Research (DZD); Eberhard Karls University of
   Tubingen; Helmholtz Association; Helmholtz-Center Munich - German
   Research Center for Environmental Health; Eberhard Karls University of
   Tubingen; Eberhard Karls University Hospital; Eberhard Karls University
   of Tubingen
RP Ullrich, S (corresponding author), Eberhard Karls Univ Tubingen, Helmholtz Ctr Munich, Inst Diabet Res & Metab Dis, Tubingen, Germany.
EM susanne.ullrich@med.uni-tuebingen.de
RI Wagner, Robert/B-3689-2012; Ullrich, Susanne/GWV-5256-2022
OI Heni, Martin/0000-0002-8462-3832; Wagner, Robert/0000-0002-6120-0191;
   Barroso Oquendo, Morgana/0000-0003-4221-5723
FU German Federal Ministry of Education and Research (BMBF) [01GI0925]
FX This study was supported by a grant (01GI0925) from the German Federal
   Ministry of Education and Research (BMBF) to the German Center for
   Diabetes Research (DZD e.V.). We gratefully acknowledge the excellent
   technical skills of Birgit Schreiner and Judith Nono (University
   Hospital Tubingen, Tubingen) for preadipocyte isolation and adipocyte
   differentiation.
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NR 140
TC 57
Z9 60
U1 1
U2 11
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 2212-8778
J9 MOL METAB
JI Mol. Metab.
PD JUL
PY 2019
VL 25
BP 1
EP 10
DI 10.1016/j.molmet.2019.05.001
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA IE2LI
UT WOS:000472215300001
PM 31113756
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU de Pablos, RM
   Espinosa-Oliva, AM
   Hornedo-Ortega, R
   Cano, M
   Arguelles, S
AF de Pablos, Rocio M.
   Maria Espinosa-Oliva, Ana
   Hornedo-Ortega, Ruth
   Cano, Mercedes
   Arguelles, Sandro
TI Hydroxytyrosol protects from aging process via AMPK and autophagy; a
   review of its effects on cancer, metabolic syndrome, osteoporosis,
   immune-mediated and neurodegenerative diseases
SO PHARMACOLOGICAL RESEARCH
LA English
DT Review
DE Aging; Senescence; Hydroxytyrosol; Mediterranean diet; AMPK; Sirtuin;
   Autophagy
ID OIL PHENOLIC-COMPOUNDS; VASCULAR ENDOTHELIAL-CELLS; REDUCES OXIDATIVE
   STRESS; HIGH CARDIOVASCULAR RISK; OLIVE OIL; MEDITERRANEAN DIET;
   DNA-DAMAGE; IN-VITRO; MOLECULAR-MECHANISM; COGNITIVE FUNCTION
AB Aging is a complex process. It is considered a risk factor for several diseases such as cancer, neurodegenerative diseases, cardiovascular diseases, and diabetes, most of which have an oxidative and inflammatory base. Given that life expectancy is increasing, there is a present interest in the search for anti-aging strategies that allow a healthy aging. Interestingly, in Spain, where the Mediterranean Diet (MD) is the reference food pattern, life expectancy will have the highest average by 2040. This diet is characterized, among other items, by virgin olive oil intake, which contains between 50-200 mg/kg of hydroxytyrosol, a major polyphenolic component of olive oil. Hydroxytyrosol is formed by the hydrolysis of oleuropein during the maturing of olives, storage of olive oil, and preparation of table olives. It is a yield of oleuropein by microbiota action in the organism after virgin olive oil consumption. The daily intake in context of the MD is estimated to be around 0.15 and 30 mg/day. In the last few years, hydroxytyrosol has received increasing attention due to its multiple pharmacological activities, such as antioxidant, anti-inflammatory and pro-apoptotic activities. It has also been the focus of extensive research regarding its bioactivity. In this sense, hydroxytyrosol is under consideration for the development of new anti-aging strategies. In this review we will summarize the potential anti-aging effects of hydroxytyrosol and its protective role in several age-related diseases.
C1 [de Pablos, Rocio M.; Maria Espinosa-Oliva, Ana] Univ Seville, Fac Pharm, Dept Biochem & Mol Biol, Seville, Spain.
   [de Pablos, Rocio M.; Maria Espinosa-Oliva, Ana] Hosp Univ Virgen Rocio, CSIC, Inst Biomed Seville IBiS, Seville, Spain.
   [Hornedo-Ortega, Ruth] Univ Bordeaux, INRA, USC 1366, MIB,Unite Rech Enol,ISVV,EA4577, Bordeaux, France.
   [Cano, Mercedes; Arguelles, Sandro] Univ Seville, Fac Pharm, Dept Physiol, Prof Garcia Gonzalez 2, E-41012 Seville, Spain.
C3 University of Sevilla; Virgen del Rocio University Hospital; Consejo
   Superior de Investigaciones Cientificas (CSIC); University of Sevilla;
   CSIC-JA-USE - Instituto de Biomedicina de Sevilla (IBIS); INRAE;
   Universite de Bordeaux; University of Sevilla
RP Arguelles, S (corresponding author), Univ Seville, Fac Pharm, Dept Physiol, Prof Garcia Gonzalez 2, E-41012 Seville, Spain.
EM sarguelles1@us.es
RI Arguelles, Sandro/Y-6343-2019; de Pablos, Rocío/L-1889-2014; Cano,
   Mercedes/L-1129-2014; Hornedo-Ortega, Ruth/F-6822-2016
OI Cano, Mercedes/0000-0002-7710-0072; Arguelles,
   Sandro/0000-0001-8450-3227; Hornedo-Ortega, Ruth/0000-0003-1898-8806
FU V Plan Propio US-Acceso [USE-14793-G]; Fundacion Alfonso Martin
   Escudero; Spanish Ministerio de Economia y Competitividad (MINECO/FEDER,
   EU) [SAF2015-64171-R]
FX S.A was supported by V Plan Propio US-Acceso USE-14793-G. Ruth
   Homedo-Ortega would also like to thank the Fundacion Alfonso Martin
   Escudero for her postdoctoral fellowship. R.M.-P and A.M.E.-O were
   supported by the Spanish Ministerio de Economia y Competitividad
   (SAF2015-64171-R; MINECO/FEDER, EU).
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NR 195
TC 110
Z9 110
U1 4
U2 101
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 1043-6618
J9 PHARMACOL RES
JI Pharmacol. Res.
PD MAY
PY 2019
VL 143
BP 58
EP 72
DI 10.1016/j.phrs.2019.03.005
PG 15
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA HW6VC
UT WOS:000466827800007
PM 30853597
DA 2025-06-11
ER

PT J
AU Hu, C
   Wang, GY
   Yin, WJ
   Zhou, Y
   Hou, J
   Wang, X
   Chen, WH
   Yuan, J
AF Hu, Chen
   Wang, Guiyang
   Yin, Wenjun
   Zhou, Yun
   Hou, Jian
   Wang, Xian
   Chen, Weihong
   Yuan, Jing
TI Central obesity transition increased urinary levels of
   8-hydroxydeoxyguanosine in male adults: A 3-year follow up study
SO METABOLISM-CLINICAL AND EXPERIMENTAL
LA English
DT Article
DE 8-Hydroxydeoxyguanosine; Hip circumference; Central obesity
ID BODY-MASS INDEX; OXIDATIVE DNA-DAMAGE; ABDOMINAL OBESITY; WAIST
   CIRCUMFERENCE; METABOLIC SYNDROME; CHINESE ADULTS; RISK-FACTORS; STRESS;
   ASSOCIATION; ACCUMULATION
AB Objective: Association of oxidative DNA damage with gain in anthropometric indices has not been fully elucidated.
   Methods: In this study, participants (n = 1151) were derived from the baseline visit of Wuhan residents in the Wuhan-Zhuhai Cohort Study. The participants finished the physical examinations at both baseline and 3-year follow up. Urinary levels of 8-hydroxydeoxyguanosine (8-OHdG) were measured by gradient-elution high performance liquid chromatography method and then calibrated by urinary creatinine (Cr) values.
   Results: Generalized linear models showed that after adjusted for confounding factors, baseline central obesity individuals with a >= 2.5% hip circumference (HC) loss or >5% HC gain had a 0.290 mu mol/mol Cr (95% confidence interval (CI): 0.108. 0.472) or 0.553 mu mol/mol Cr (95% CI: 0.273, 0.833) increase in urinary 8-OHdG levels compared with those with a -2.5%-2.5% HC gain (both P< 0.05). Moreover, compared with non-central obesity at both baseline and 3 year follow-up, we observed that central obese men at both baseline and 3-year follow-up had a 0.46 mu mol/mol Cr (95% CI: 0.16, 0.75) increased in urinary 8-OHdG levels.
   Conclusions: HC gain showed dose-dependent associations with urinary 8-OHdG levels. Moreover, male central obesity at both baseline and 3-year follow-up had an increased risk for urinary 8-OHdG levels. (C) 2018 Elsevier Inc. All rights reserved.
C1 [Hu, Chen; Wang, Guiyang; Yin, Wenjun; Zhou, Yun; Hou, Jian; Wang, Xian; Chen, Weihong; Yuan, Jing] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Dept Occupat & Environm Hlth,Minist Educ, Hangkong Rd 13, Wuhan 430030, Hubei, Peoples R China.
   [Hu, Chen; Wang, Guiyang; Yin, Wenjun; Zhou, Yun; Hou, Jian; Wang, Xian; Chen, Weihong; Yuan, Jing] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Minist Environm Protect, Hangkong Rd 13, Wuhan 430030, Hubei, Peoples R China.
   [Hu, Chen; Wang, Guiyang; Yin, Wenjun; Zhou, Yun; Hou, Jian; Wang, Xian; Chen, Weihong; Yuan, Jing] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, State Key Lab Environm Hlth Incubating, Hangkong Rd 13, Wuhan 430030, Hubei, Peoples R China.
   [Hu, Chen; Wang, Guiyang; Yin, Wenjun; Zhou, Yun; Hou, Jian; Wang, Xian; Chen, Weihong; Yuan, Jing] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Key Lab Environm & Hlth,Minist Educ, Hangkong Rd 13, Wuhan 430030, Hubei, Peoples R China.
C3 Huazhong University of Science & Technology; Ministry of Education -
   China; Huazhong University of Science & Technology; Huazhong University
   of Science & Technology; Huazhong University of Science & Technology;
   Ministry of Education - China
RP Yuan, J (corresponding author), Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Dept Occupat & Environm Hlth,Minist Educ, Hangkong Rd 13, Wuhan 430030, Hubei, Peoples R China.; Yuan, J (corresponding author), Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Minist Environm Protect, Hangkong Rd 13, Wuhan 430030, Hubei, Peoples R China.; Yuan, J (corresponding author), Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, State Key Lab Environm Hlth Incubating, Hangkong Rd 13, Wuhan 430030, Hubei, Peoples R China.
EM jyuan@tjh.tjmu.edu.cn
RI Chen, Weihong/D-2177-2011; Yin, Wenjun/AAU-4546-2021; Hou,
   Jian/AAC-1400-2022; Wang, Ying/KBT-7521-2024
OI Hou, Jian/0000-0002-8478-0416; Wang, Guiyang/0000-0001-7380-6783
FU Public Sector Program of National Environmental Protection of the
   People's Republic of China [201409081]; Key Project of the National
   Natural Science Foundation of China [91543207]; National Key Research
   and Development Plan of China [2016YFC1303903]
FX This work was supported by funds fromthe Public Sector Program of
   National Environmental Protection of the People's Republic of China (No.
   201409081), the Key Project of the National Natural Science Foundation
   of China (No. 91543207) and the National Key Research and Development
   Plan of China (No. 2016YFC1303903).
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NR 46
TC 4
Z9 4
U1 0
U2 17
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0026-0495
EI 1532-8600
J9 METABOLISM
JI Metab.-Clin. Exp.
PD FEB
PY 2019
VL 91
BP 53
EP 60
DI 10.1016/j.metabol.2018.11.015
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA IB5HJ
UT WOS:000470301900007
PM 30513280
DA 2025-06-11
ER

PT J
AU Ko, SH
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   Ko, SY
   Shin, SB
   Ko, SH
   Ahn, YB
AF Ko, Sun-Hye
   Baeg, Myong Ki
   Han, Kyung-Do
   Ko, Seung-Yeon
   Shin, Sae-Bom
   Ko, Seung-Hyun
   Ahn, Yu-Bae
TI Association between gamma-glutamyltransferase and albuminuria in
   nondiabetic adults with normal renal function
SO CLINICAL AND EXPERIMENTAL NEPHROLOGY
LA English
DT Article
DE Albuminuria; Gamma-glutamyltransferase; Aspartate aminotransferase;
   Korean National Health and Nutrition Examination Survey
ID CHRONIC KIDNEY-DISEASE; CARDIOVASCULAR RISK-FACTORS; OXIDATIVE STRESS;
   ENDOTHELIAL DYSFUNCTION; METABOLIC SYNDROME; MICROALBUMINURIA;
   HYPERTENSION; DEATH; INDIVIDUALS; PREVALENCE
AB Background Serum gamma-glutamyltransferase (GGT) has been associated with albuminuria in diabetes patients, but it has not been investigated in the general population. We aimed to investigate the association between serum GGT and albuminuria in the nondiabetic Korean population with normal kidney function.
   Methods Study participants (3948; 1549 men and 2399 women) with an estimated glomerular filtration rate >= 60 mL/min/1.73 m(2) were analyzed from the fifth Korean National Health and Nutrition Examination Survey (2011). Albuminuria was defined as an albumin-creatinine ratio > 30 mg/g. Serum GGT was analyzed by dividing into quartiles. Multiple logistic models were used to analyze the associations between GGT and albuminuria.
   Results The prevalence of albuminuria was 5.1% and increased linearly according to increasing GGT quartiles (P for trend = 0.005). A linear regression analysis revealed that GGT was positively related with albuminuria (P = 0.008). After adjusting for confounding factors, the odds ratio for albuminuria was 1.80 (95% CI 1.079-3.010, P for trend = 0.029) for the highest quartile group compared with those observed in the lowest quartile of GGT. In addition, this independent relationship did not change when the cut-off value of GGT (30 IU/L) was applied to this analysis. Compared with GGT value <= 30 IU/L, the adjusted odds ratio of albuminuria in participants with GGT > 30 IU/L was 1.96 (95% CI 1.319-2.906, P < 0.001).
   Conclusion Higher serum GGT levels within the reference range were significantly associated with albuminuria in nondiabetic Koreans with preserved kidney function, independently of traditional cardio-renal risk factors.
C1 [Ko, Sun-Hye; Shin, Sae-Bom; Ko, Seung-Hyun; Ahn, Yu-Bae] Catholic Univ Korea, St Vincents Hosp, Div Endocrinol & Metab, Dept Internal Med,Coll Med, 222 Banpo Daero, Seoul 137701, South Korea.
   [Baeg, Myong Ki] Catholic Univ Korea, Seoul St Marys Hosp, Div Gastroenterol & Hepatol, Dept Internal Med,Coll Med, Seoul, South Korea.
   [Han, Kyung-Do] Catholic Univ Korea, Dept Biostat, Coll Med, Seoul, South Korea.
   [Ko, Seung-Yeon] Catholic Univ Korea, Dept Gen Surg, Coll Med, Seoul, South Korea.
C3 Catholic University of Korea; Seoul St. Mary's Hospital; Catholic
   University of Korea; Catholic University of Korea; Catholic University
   of Korea
RP Ahn, YB (corresponding author), Catholic Univ Korea, St Vincents Hosp, Div Endocrinol & Metab, Dept Internal Med,Coll Med, 222 Banpo Daero, Seoul 137701, South Korea.
EM ybahn@catholic.ac.kr
RI Han, Kyungdo/JKH-7628-2023; Ko, Sun Hye/AGQ-5472-2022; Baeg, Myong
   Ki/O-1531-2017
OI Ko, Sun Hye/0000-0003-3387-3986; Baeg, Myong Ki/0000-0002-4807-2447
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NR 31
TC 4
Z9 5
U1 0
U2 3
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1342-1751
EI 1437-7799
J9 CLIN EXP NEPHROL
JI Clin. Exp. Nephrol.
PD OCT
PY 2017
VL 21
IS 5
BP 835
EP 841
DI 10.1007/s10157-016-1356-7
PG 7
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA FK2LO
UT WOS:000413313900013
PM 27933415
DA 2025-06-11
ER

PT J
AU Wester, VL
   Noppe, G
   Savas, M
   van den Akker, ELT
   de Rijke, YB
   van Rossum, EFC
AF Wester, Vincent L.
   Noppe, Gerard
   Savas, Mesut
   van den Akker, Erica L. T.
   de Rijke, Yolanda B.
   van Rossum, Elisabeth F. C.
TI Hair analysis reveals subtle HPA axis suppression associated with use of
   local corticosteroids: The Lifelines cohort study
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE Hair cortisol; Hair cortisone; Glucocorticoids; Corticosteroids; Life
   events
ID LONG-TERM CORTISOL; SCALP HAIR; CUSHINGS-SYNDROME; STRESS; HEALTH;
   DIAGNOSIS; DISEASE; SAMPLES
AB Background and aims: Scalp hair is increasingly used to measure the long-term exposure to endogenous glucocorticoids hormones. Long-term cortisone (HairE) and cortisol (HairF) have been associated with obesity, metabolic syndrome, cardiovascular disease and psychopathology. However, little is known about the influence of the use of local corticosteroids and major stressful life events on hair glucocorticoids.
   Materials and methods: We determined HairE and HairF using liquid chromatography tandem mass spectrometry in 295 adult participants of the population-based Lifelines cohort study (75% females, median age 42). We collected anthropometry and fasting metabolic laboratory values, questionnaires on hair characteristics, recent use of corticosteroids, and recent major stressful life events.
   Results: After adjustment for covariates, hair glucocorticoids increased with age, male sex, black or brown hair color, and frequency of sweating on the scalp, and decreased with higher hair washing frequency (P < 0.05). HairE was decreased in participants who used systemic corticosteroids (5.4 vs. 8.5 pg/mg hair, P=0.041), and in participants who only used local agents such as inhaled, topical and nasal corticosteroids (6.8 vs. 8.5 pg/mg, P=0.005). Recent life events were positively associated with HairF after adjustment for age and sex (P = 0.026), but this association lost significance after adjustment for hair related characteristics (P > 0.05).
   Conclusions: HairE can be a useful marker to detect mild adrenal suppression due to corticosteroid use in the general population, even when only inhaled, nasal or topical corticosteroids are used, which suggests that these commonly used agents induce systemic effects. (C) 2017 Elsevier Ltd. All rights reserved.
C1 [Wester, Vincent L.; Noppe, Gerard; Savas, Mesut; van Rossum, Elisabeth F. C.] Univ Med Ctr Rotterdam, Erasmus MC, Div Endocrinol, Dept Internal Med, Rotterdam, Netherlands.
   [Wester, Vincent L.; Savas, Mesut; van den Akker, Erica L. T.; van Rossum, Elisabeth F. C.] Univ Med Ctr Rotterdam, Erasmus MC, Obes Ctr CGG, Rotterdam, Netherlands.
   [van den Akker, Erica L. T.] Univ Med Ctr Rotterdam, Erasmus MC, Dept Pediat, Rotterdam, Netherlands.
   [de Rijke, Yolanda B.] Univ Med Ctr Rotterdam, Erasmus MC, Dept Clin Chem, Rotterdam, Netherlands.
   [van Rossum, Elisabeth F. C.] Lifelines Cohort Study & Biobank, Groningen, Netherlands.
C3 Erasmus University Rotterdam; Erasmus MC; Erasmus University Rotterdam;
   Erasmus MC; Erasmus University Rotterdam; Erasmus MC; Erasmus University
   Rotterdam; Erasmus MC
RP van Rossum, EFC (corresponding author), Erasmus MC, Room D428,POB 2040, NL-3000 CA Rotterdam, Netherlands.
EM e.vanrossum@erasmusmc.nl
RI Savas, Mesut/AAE-6955-2021; de Rijke, Yolanda/AAQ-5497-2020; van Rossum,
   Elisabeth/AAP-9388-2020
OI van Rossum, Elisabeth/0000-0003-0120-4913
CR Abell JG, 2016, PSYCHONEUROENDOCRINO, V73, P148, DOI 10.1016/j.psyneuen.2016.07.214
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NR 29
TC 36
Z9 41
U1 1
U2 17
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD JUN
PY 2017
VL 80
BP 1
EP 6
DI 10.1016/j.psyneuen.2017.02.024
PG 6
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA EW2UT
UT WOS:000402352200001
PM 28288364
DA 2025-06-11
ER

PT J
AU Das, N
   Mandala, A
   Naaz, S
   Giri, S
   Jain, M
   Bandyopadhyay, D
   Reiter, RJ
   Roy, SS
AF Das, Nabanita
   Mandala, Ashok
   Naaz, Shamreen
   Giri, Suresh
   Jain, Mukul
   Bandyopadhyay, Debasish
   Reiter, Russel J.
   Roy, Sib Sankar
TI Melatonin protects against lipid-induced mitochondrial dysfunction in
   hepatocytes and inhibits stellate cell activation during hepatic
   fibrosis in mice
SO JOURNAL OF PINEAL RESEARCH
LA English
DT Article
DE fibrogenesis; hepatic steatosis; hepatic stellate cells; hepatocytes;
   melatonin; mitochondria; palmitate
ID NONALCOHOLIC FATTY LIVER; PERMEABILITY TRANSITION PORE; OXIDATIVE
   STRESS; METABOLIC SYNDROME; INSULIN-RESISTANCE; RESPIRATORY-CHAIN;
   SKELETAL-MUSCLE; SIRTUIN 1; STEATOHEPATITIS; FISSION
AB Lipid generates reactive oxygen species (ROS) in consequence to mitochondrial fission followed by inflammation in propagating hepatic fibrosis. The interaction of SIRT1/Mitofusin2 is critical for maintaining mitochondrial integrity and functioning, which is disrupted upon excess lipid infiltration during the progression of steatohepatitis. The complex interplay between hepatic stellate cells and steatotic hepatocytes is critically regulated by extracellular factors including increased circulating free fatty acids during fibrogenesis. Melatonin, a potent antioxidant, protects against lipid-mediated mitochondrial ROS generation. Lipotoxicity induces disruption of SIRT1 and Mitofusin2 interaction leading to mitochondrial morphological disintegration in hepatocytes. Further, fragmented mitochondria leads to mitochondrial permeability transition pore opening, cell cycle arrest and apoptosis and melatonin protects against all these lipotoxicity-mediated dysfunctions. These impaired mitochondrial dynamics also enhances the cellular glycolytic flux and reduces mitochondrial oxygen consumption rate that potentiates ROS production. High glycolytic flux generates metabolically unfavorable milieu in hepatocytes leading to inflammation, which is abrogated by melatonin. The melatonin-mediated protection against mitochondrial dysfunction was also observed in high-fat diet (HFD)-fed mice through restoration of enzymatic activities associated with respiratory chain and TCA cycle. Subsequently, melatonin reduces hepatic fat deposition and inflammation in HFD-fed mice. Thus, melatonin disrupts the interaction between steatotic hepatocyte and stellate cells, leading to the activation of the latter to abrogate collagen deposition. Altogether, the results of the current study document that the pharmacological intervention with low dose of melatonin could abrogate lipotoxicity-mediated hepatic stellate cell activation and prevent the fibrosis progression.
C1 [Das, Nabanita; Mandala, Ashok; Roy, Sib Sankar] Indian Inst Chem Biol, CSIR, Cell Biol & Physiol Div, Kolkata, India.
   [Mandala, Ashok; Roy, Sib Sankar] Indian Inst Chem Biol, CSIR, Acad Sci & Innovat Res, Kolkata, India.
   [Naaz, Shamreen; Bandyopadhyay, Debasish] Univ Calcutta, Univ Coll Sci & Technol, Dept Physiol, Oxidat Stress & Free Rad Biol Lab, Kolkata, India.
   [Giri, Suresh; Jain, Mukul] Cadila Healthcare Ltd, Zydus Res Ctr, Ahmadabad, Gujarat, India.
   [Reiter, Russel J.] Univ Texas Hlth Sci Ctr San Antonio, Dept Cellular & Struct Biol, San Antonio, TX 78229 USA.
C3 Council of Scientific & Industrial Research (CSIR) - India; CSIR -
   Indian Institute of Chemical Biology (IICB); Council of Scientific &
   Industrial Research (CSIR) - India; CSIR - Indian Institute of Chemical
   Biology (IICB); Academy of Scientific & Innovative Research (AcSIR);
   University of Calcutta; Zydus Cadila; University of Texas System;
   University of Texas Health Science Center at San Antonio
RP Roy, SS (corresponding author), Indian Inst Chem Biol, CSIR, Cell Biol & Physiol Div, Council Sci & Ind Res, Kolkata, India.
EM sibsankar@iicb.res.in
RI Bandyopadhyay, Debasish/AFC-7830-2022; Mandala, Ashok/J-4734-2019; Naaz,
   Shamreen/KIJ-7255-2024; Reiter, Russel/D-3221-2009
OI Bandyopadhyay, Debasish/0000-0001-7993-0777; Mandala,
   Ashok/0000-0003-3473-2456
FU Council of Scientific and Industrial Research [BSC0206,
   31/002(0889)/2011-EMR-1, 31/GATE/02(21)/2012-EMR-I]; Department of
   Physiology, University of Calcutta [BI92]
FX Council of Scientific and Industrial Research, Grant/Award Number:
   BSC0206, 31/002(0889)/2011-EMR-1 and 31/GATE/02(21)/2012-EMR-I;
   Department of Physiology, University of Calcutta, Grant/Award Number:
   BI92
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NR 68
TC 137
Z9 147
U1 1
U2 71
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0742-3098
EI 1600-079X
J9 J PINEAL RES
JI J. Pineal Res.
PD MAY
PY 2017
VL 62
IS 4
AR e12404
DI 10.1111/jpi.12404
PG 21
WC Endocrinology & Metabolism; Neurosciences; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Physiology
GA EQ9FV
UT WOS:000398390900008
PM 28247434
DA 2025-06-11
ER

PT J
AU Zhang, LF
   Cai, YQ
   Wei, SJ
   Ling, Y
   Zhu, L
   Li, DF
   Cai, ZW
AF Zhang, Lifan
   Cai, Yueqin
   Wei, Shengjuan
   Ling, Yun
   Zhu, Liang
   Li, Dongfeng
   Cai, Zhaowei
TI Testosterone Deficiency Induces Changes of the Transcriptomes of
   Visceral Adipose Tissue in Miniature Pigs Fed a High-Fat and
   High-Cholesterol Diet
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE testosterone deficiency; visceral adipose tissue; inflammatory response;
   miniature pigs; RNA-Seq
ID HYPOGONADAL MEN; INSULIN-RESISTANCE; METABOLIC SYNDROME; MACROPHAGE
   INFILTRATION; REPLACEMENT THERAPY; APOLIPOPROTEIN A5; LEPTIN PRODUCTION;
   OXIDATIVE STRESS; OBESITY; EXPRESSION
AB Testosterone deficiency causes fat deposition, particularly in visceral fat, and its replacement might reverse fat accumulation, however, the underlying mechanisms of such processes under diet-induced adiposity are largely unknown. To gain insights into the genome-wide role of androgen on visceral adipose tissue (VAT), RNA-Seq was used to investigate testosterone deficiency induced changes of VAT in miniature pigs fed a high-fat and high-cholesterol (HFC) diet among intact male pigs (IM), castrated male pigs (CM), and castrated male pigs with testosterone replacement (CMT) treatments. The results showed that testosterone deficiency significantly increased VAT deposition and serum leptin concentrations. Moreover, a total of 1732 differentially expressed genes (DEGs) were identified between any two groups. Compared with gene expression profiles in IM and CMT pigs, upregulated genes in CM pigs, i.e., LOC100520753 (CD68), LCN2, EMR1, S100A9, NCF1 (p47phox), and LEP, were mainly involved in inflammatory response, oxidation-reduction process, and lipid metabolic process, while downregulated genes in CM pigs, i.e., ABHD5, SPP1, and GAS6, were focused on cell differentiation and cell adhesion. Taken together, our study demonstrates that testosterone deficiency alters the expression of numerous genes involved in key biological processes of VAT accumulation under HFC diet and provides a novel genome-wide view on the role of androgen on VAT deposition under HFC diet, thus improving our understanding of the molecular mechanisms involved in VAT changes induced by testosterone deficiency.
C1 [Zhang, Lifan; Wei, Shengjuan; Li, Dongfeng] Nanjing Agr Univ, Coll Anim Sci & Technol, Nanjing 210095, Jiangsu, Peoples R China.
   [Cai, Yueqin; Ling, Yun; Zhu, Liang; Cai, Zhaowei] Zhejiang Chinese Med Univ, Lab Anim Res Ctr, Hangzhou 310053, Zhejiang, Peoples R China.
C3 Nanjing Agricultural University; Zhejiang Chinese Medical University
RP Zhang, LF (corresponding author), Nanjing Agr Univ, Coll Anim Sci & Technol, Nanjing 210095, Jiangsu, Peoples R China.; Cai, ZW (corresponding author), Zhejiang Chinese Med Univ, Lab Anim Res Ctr, Hangzhou 310053, Zhejiang, Peoples R China.
EM lifanzhang@njau.edu.cn; cyq810@hotmail.com; sjwei@njau.edu.cn;
   lyun1983@163.com; tozhuliang@126.com; lidongfeng@njau.edu.cn;
   zwcai@zcmu.edu.cn
RI Liu, You-Nian/G-2697-2013; Zhang, Lifan/HJI-3945-2023
OI cai, zhaowei/0000-0002-0752-1541; , Lifan/0000-0002-8166-9173
FU Fundamental Research Funds for the Central Universities [KYZ201414];
   National Natural Science Foundation of China [31200921, 31501930];
   Ministry of Science and Technology of China [2015BAD03B01]; Natural
   Science Foundation of Jiangsu Province of China [BK20150656, BK20150669]
FX This work was supported by the Fundamental Research Funds for the
   Central Universities (KYZ201414), the National Natural Science
   Foundation of China (31200921 and 31501930), the National Key Technology
   Research and Development Program of the Ministry of Science and
   Technology of China (2015BAD03B01), and the Natural Science Foundation
   of Jiangsu Province of China (BK20150656 and BK20150669).
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NR 68
TC 5
Z9 9
U1 0
U2 13
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD DEC
PY 2016
VL 17
IS 12
AR 2125
DI 10.3390/ijms17122125
PG 16
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA EI1XR
UT WOS:000392280500169
PM 27999286
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Leboyer, M
   Oliveira, J
   Tamouza, R
   Groc, L
AF Leboyer, Marion
   Oliveira, Jose
   Tamouza, Ryad
   Groc, Laurent
TI Is it time for immunopsychiatry in psychotic disorders?
SO PSYCHOPHARMACOLOGY
LA English
DT Review
DE Schizophrenia; Bipolar disorder; Immunopsychiatry; Immunogenetics;
   Gene-environment interactions; NMDA receptor; HERV-W
ID NMDA RECEPTOR ENCEPHALITIS; CEREBROSPINAL-FLUID INTERLEUKIN-1-BETA;
   RETROVIRUS-W FAMILY; C-REACTIVE PROTEIN; BIPOLAR DISORDER;
   SCHIZOPHRENIC-PATIENTS; CYTOKINE ALTERATIONS; AUTOIMMUNE-DISEASES;
   METABOLIC SYNDROME; TOXOPLASMA-GONDII
AB Introduction: Immune dysregulation is suggested to play an important aetiological role in schizophrenia (SZ) and bipolar disorder (BD) potentially driving neurodevelopmental pathways. Immune dysfunction may precede the onset of psychiatric disorders and parallel the development of multiaxial comorbidity, including suicidal behaviour and metabolic and autoimmune disorders. Depicting the source of the chronic low-grade inflammatory component in SZ and BD is thus a research priority. Strong environmental insults early in life, such as infections, acting on a background of genetic vulnerability, may induce potent and enduring inflammatory responses setting a state of liability to second-hit environmental encounters, namely childhood trauma, drug abuse or additional infectious exposures. The immunogenetic background of susceptibility, suggested to be not only lying within the HLA locus but also implicating inherited deficits of the innate immune system, may amplify the harmful biological effects of infections/psychosocial stress leading to the manifestation of a broad range of psychiatric symptoms.
   Objectives: The present review aims to discuss the following: (i) biological arguments in favour of a chronic low-grade inflammation in SZ and BD and its potential origin in the interaction between the immunogenetic background and environmental infectious insults, and (ii) the consequences of this inflammatory dysfunction by focusing on N-methyl-D-aspartate (NMDA) receptor antibodies and activation of the family of human endogenous retroviruses (HERVs).
   Conclusions: Specific therapeutic approaches targeting immune pathways may lead the way to novel personalized medical interventions, improvement of quality of life and average life expectancy of psychiatric patients, if not even prevent mood episodes and psychotic symptoms.
C1 [Leboyer, Marion; Oliveira, Jose] Univ Paris Est, INSERM U955, Lab Psychiat Translat, F-94000 Creteil, France.
   [Leboyer, Marion; Oliveira, Jose] Hop Univ Henri Mondor, AP HP, DHU Pe PSY, Pole Psychiat & Addictol, F-94000 Creteil, France.
   [Leboyer, Marion; Oliveira, Jose] Fdn FondaMental, F-94000 Creteil, France.
   [Oliveira, Jose; Tamouza, Ryad] Univ Paris Diderot, Sorbonne Paris Cite, Hop St Louis, Lab Jean Dausset,INSERM,U1160, Paris, France.
   [Oliveira, Jose; Tamouza, Ryad] Univ Paris Diderot, Sorbonne Paris Cite, Hop St Louis, LabEx Transplantex, Paris, France.
   [Groc, Laurent] Univ Bordeaux, CNRS, Interdisciplinary Inst Neurosci, UMR 5297, F-33000 Bordeaux, France.
   [Leboyer, Marion] Hop Albert Chenevier, Pole Psychiat, 40 Rue Mesly, F-94000 Creteil, France.
C3 Universite Paris-Est-Creteil-Val-de-Marne (UPEC); Institut National de
   la Sante et de la Recherche Medicale (Inserm); Universite
   Paris-Est-Creteil-Val-de-Marne (UPEC); Assistance Publique Hopitaux
   Paris (APHP); Hopital Universitaire Henri-Mondor - APHP; Institut
   National de la Sante et de la Recherche Medicale (Inserm); Assistance
   Publique Hopitaux Paris (APHP); Universite Paris Cite; Hopital
   Universitaire Saint-Louis - APHP; Assistance Publique Hopitaux Paris
   (APHP); Universite Paris Cite; Hopital Universitaire Saint-Louis - APHP;
   Centre National de la Recherche Scientifique (CNRS); CNRS - National
   Institute for Biology (INSB); Universite de Bordeaux; Assistance
   Publique Hopitaux Paris (APHP); Universite
   Paris-Est-Creteil-Val-de-Marne (UPEC); Hopital Universitaire
   Henri-Mondor - APHP
RP Leboyer, M (corresponding author), Univ Paris Est, INSERM U955, Lab Psychiat Translat, F-94000 Creteil, France.; Leboyer, M (corresponding author), Hop Univ Henri Mondor, AP HP, DHU Pe PSY, Pole Psychiat & Addictol, F-94000 Creteil, France.; Leboyer, M (corresponding author), Fdn FondaMental, F-94000 Creteil, France.; Leboyer, M (corresponding author), Hop Albert Chenevier, Pole Psychiat, 40 Rue Mesly, F-94000 Creteil, France.
EM marion.leboyer@inserm.fr
RI Leboyer, Marion/AAW-3648-2021; Oliveira, José/P-8459-2019; Tamouza,
   Ryad/AGQ-6644-2022
OI LEBOYER, Marion/0000-0001-5473-3697; Oliveira, Jose/0000-0003-3475-4794
CR [Anonymous], MOL PSYCHIAT
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NR 125
TC 79
Z9 86
U1 2
U2 28
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0033-3158
EI 1432-2072
J9 PSYCHOPHARMACOLOGY
JI Psychopharmacology
PD MAY
PY 2016
VL 233
IS 9
BP 1651
EP 1660
DI 10.1007/s00213-016-4266-1
PG 10
WC Neurosciences; Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA DJ4MS
UT WOS:000374180400009
PM 26988846
DA 2025-06-11
ER

PT J
AU Méndez, I
   Vázquez-Martínez, O
   Hernández-Muñoz, R
   Valente-Godínez, H
   Díaz-Muñoz, M
AF Mendez, Isabel
   Vazquez-Martinez, Olivia
   Hernandez-Munoz, Rolando
   Valente-Godinez, Hector
   Diaz-Munoz, Mauricio
TI Redox regulation and pro-oxidant reactions in the physiology of
   circadian systems
SO BIOCHIMIE
LA English
DT Review
DE Circadian; Redox; Molecular clock; ROS; Peroxiredoxin; Melatonin
ID SUPEROXIDE-DISMUTASE ACTIVITY; CLOCK GENE-EXPRESSION; FOOD-RESTRICTED
   RATS; OXIDATIVE STRESS; NITRIC-OXIDE; HYDROPEROXIDE METABOLISM;
   DROSOPHILA-MELANOGASTER; SUPRACHIASMATIC NUCLEUS; PYRIDINE-NUCLEOTIDES;
   LIPID-PEROXIDATION
AB Rhythms of approximately 24 h are pervasive in most organisms and are known as circadian. There is a molecular circadian clock in each cell sustained by a feedback system of interconnected "clock" genes and transcription factors. In mammals, the timing system is formed by a central pacemaker, the suprachiasmatic nucleus, in coordination with a collection of peripheral oscillators. Recently, an extensive interconnection has been recognized between the molecular circadian clock and the set of biochemical pathways that underlie the bioenergetics of the cell. A principle regulator of metabolic networks is the flow of electrons between electron donors and acceptors. The concomitant reduction and oxidation (redox) reactions directly influence the balance between anabolic and catabolic processes. This review summarizes and discusses recent findings concerning the mutual and dynamic interactions between the molecular circadian clock, redox reactions, and redox signaling. The scope includes the regulatory role played by redox coenzymes (NAD(P)+/NAD(P)H, GSH/GSSG), reactive oxygen species (superoxide anion, hydrogen peroxide), antioxidants (melatonin), and physiological events that modulate the redox state (feeding condition, circadian rhythms) in determining the timing capacity of the molecular circadian clock. In addition, we discuss a purely metabolic circadian clock, which is based on the redox enzymes known as peroxiredoxins and is present in mammalian red blood cells and in other biological systems. Both the timing system and the metabolic network are key to a better understanding of widespread pathological conditions such as the metabolic syndrome, obesity, and diabetes. (C) 2015 Elsevier B.V. and Societe Francaise de Biochimie et Biologie Moleculaire (SFBBM). All rights reserved.
C1 [Mendez, Isabel; Vazquez-Martinez, Olivia; Valente-Godinez, Hector; Diaz-Munoz, Mauricio] Inst Neurobiol, Dept Neurobiol Celular & Mol, Campus UNAM Juriquilla, Queretaro 76230, Qro, Mexico.
   [Hernandez-Munoz, Rolando] Univ Nacl Autonoma Mexico, Dept Biol Celular & Desarrollo, Inst Fisiol Celular, Ciudad Univ, Mexico City 04510, DF, Mexico.
C3 Universidad Nacional Autonoma de Mexico; Universidad Nacional Autonoma
   de Mexico
RP Díaz-Muñoz, M (corresponding author), Dept Neurobiol Celular & Mol, Campus UNAM Juriquilla, Queretaro 76230, Qro, Mexico.
EM mdiaz@comunidad.unam.mx
RI ; Mendez, Isabel/I-5719-2013
OI Diaz-Munoz, Mauricio/0000-0002-9019-8246; Mendez,
   Isabel/0000-0002-6731-9468
FU Consejo Nacional de Ciencia y Tecnologia (CONACyT) [129-511]; Direccion
   General de Apoyo al Personal Academic (DGAPA) [IN202412, IA200713]
FX We thank Dr. Dorothy Pless for her assistance in English edition and LN
   Fernando Lopez-Barrera for help in Figures edition. MDM is supported by
   grants from Consejo Nacional de Ciencia y Tecnologia (CONACyT, 129-511)
   and Direccion General de Apoyo al Personal Academic (DGAPA, IN202412),
   and IM is supported by grant from Direccion General de Apoyo al Personal
   Academic (DGAPA, IA200713).
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NR 97
TC 36
Z9 36
U1 0
U2 41
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0300-9084
EI 1638-6183
J9 BIOCHIMIE
JI Biochimie
PD MAY
PY 2016
VL 124
BP 178
EP 186
DI 10.1016/j.biochi.2015.04.014
PG 9
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA DK4UZ
UT WOS:000374917100020
PM 25926044
DA 2025-06-11
ER

PT J
AU Schwartz, SS
   Zangeneh, F
AF Schwartz, Stanley S.
   Zangeneh, Farhad
TI Evidence-based practice use of quick-release bromocriptine across the
   natural history of type 2 diabetes mellitus
SO POSTGRADUATE MEDICINE
LA English
DT Review
DE Bromocriptine; dopamine; diabetes; cardiovascular risk; insulin
   resistance
ID INSULIN-RESISTANCE; METABOLIC SYNDROME; VENTROMEDIAL HYPOTHALAMUS;
   CLINICAL ENDOCRINOLOGISTS; AMERICAN ASSOCIATION; GLUCOSE-INTOLERANCE;
   BIOLOGICAL CLOCK; GLYCEMIC CONTROL; REDUCES OBESITY; PLASMA-GLUCOSE
AB Objectives: To provide an evidence-based practice overview on the clinical use of bromocriptine-quick release (QR) across the natural history of type 2 diabetes mellitus (T2DM).Methods: Articles for inclusion were selected after a comprehensive literature search of English-language PubMed articles and identification of other relevant references through other sources. Inclusion criteria were animal studies examining the mechanism of action and efficacy of bromocriptine, and clinical studies examining the safety and efficacy of bromocriptine-QR in patients with T2DM, without a time limitation.Results: The brain plays a key role in total body metabolism, in particular ensuring that sufficient levels of glucose are available for proper neural functioning. The hypothalamic suprachiasmatic nucleus (SCN), the body's biological clock, plays a key role in the regulation of seasonal and diurnal variations of insulin sensitivity. A daily surge of dopaminergic activity in the SCN upon waking enables insulin sensitivity throughout the day. When this is disrupted (e.g. by a high fat/sugar diet, stress, altered [diminished] exercise, altered sleep/wake cycle, diabetes), insulin resistance persists throughout the day and overnight. Improving the morning surge in dopaminergic activity with the short-acting dopamine D2 receptor agonist bromocriptine-QR can safely and effectively improve glycemic control, while improving cardiovascular disease risk factors and related adverse events, and reducing sympathetic tone, as demonstrated by 5 reports of the Cycloset Safety Trial and 3 additional clinical studies of bromocriptine-QR.Conclusions: In patients with T2DM, the dopamine D2 receptor agonist bromocriptine-QR has been shown to be well tolerated, efficacious, and a logical treatment option.
C1 [Schwartz, Stanley S.] Main Line Hlth Syst, Wynnewood, PA USA.
   [Schwartz, Stanley S.] Univ Penn, Philadelphia, PA 19104 USA.
   [Zangeneh, Farhad] Endocrine Diabet & Osteoporosis Clin, Sterling, VA USA.
C3 University of Pennsylvania
RP Schwartz, SS (corresponding author), 233 E Lancaster Ave,Suite 305, Ardmore, PA 19003 USA.
EM stschwar@gmail.com
RI Schwartz, S/I-9628-2019
FU Salix Pharmaceuticals, Raleigh, NC, USA
FX Technical editorial support for this article was funded by Salix
   Pharmaceuticals, Raleigh, NC, USA.
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NR 94
TC 16
Z9 18
U1 0
U2 7
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0032-5481
EI 1941-9260
J9 POSTGRAD MED
JI Postgrad. Med.
PY 2016
VL 128
IS 8
BP 828
EP 838
DI 10.1080/00325481.2016.1214059
PG 11
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA EC2GT
UT WOS:000387928500015
PM 27458683
DA 2025-06-11
ER

PT J
AU Wang, QY
   Sun, XH
   Li, XB
   Dong, X
   Li, P
   Zhao, L
AF Wang, Qiuyan
   Sun, Xiaohui
   Li, Xiaobin
   Dong, Xiang
   Li, Peng
   Zhao, Li
TI Resveratrol attenuates intermittent hypoxia-induced insulin resistance
   in rats: Involvement of Sirtuin 1 and the
   phosphatidylinositol-4,5-bisphosphate 3-kinase/AKT pathway
SO MOLECULAR MEDICINE REPORTS
LA English
DT Article
DE resveratrol; intermittent hypoxia; insulin resistance; sirtuin 1;
   obstructive sleep apnea
ID OBSTRUCTIVE SLEEP-APNEA; METABOLIC SYNDROME; OXIDATIVE STRESS;
   SKELETAL-MUSCLE; PHOSPHOINOSITIDE 3-KINASE; RISK-FACTOR; LIFE-SPAN;
   MICE; KINASE; TARGET
AB Obstructive sleep apnea can induce chronic intermittent hypoxia (CIH) during sleep and is associated with obesity and diabetes. Resveratrol (RSV), a polyphenolic phytoalexin, can regulate glucose metabolism, thereby reducing insulin resistance. The present study aimed to assess whether RSV attenuates CIH-induced insulin resistance in rats and the underlying mechanisms. A total of 40 rats were randomly assigned into five groups: i) Control; ii) subjected to CIH only; iii) subjected to CIH and treated with 3 mg/kg/day of RSV; iv) subjected to CIH and treated with 30 mg/kg/day of RSV; v) subjected to CIH and treated with 60 mg/kg/day of RSV. All animals were sacrificed following 28 days of treatment. Subsequently, the blood and livers were harvested and blood insulin and glucose levels were measured. Levels of sirtuin (Sirt) 1, insulin receptor (InsR) and glucose transporter 2 (Glut2) in the liver were measured. RSV treatment was demonstrated to suppress weight gain and improve hepatic morphology. RSV treatment also significantly reduced the homeostasis model assessment estimate of insulin resistance of the rats exposed to CIH. This effect occurred in a dose-dependent manner. RSV significantly upregulated liver Sirt1 levels and inhibited InsR and Glut2 expression in the liver. Additionally, RSV activated the phosphorylation of phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K) and AKT. The present study demonstrates that RSV prevents CIH-induced insulin resistance in rats. Upregulation of Sirt1 and activation of PI3K/AKT signaling may be involved in this process.
C1 [Wang, Qiuyan; Li, Peng; Zhao, Li] China Med Univ, Dept Resp Med, Shengjing Hosp, Shenyang 110001, Liaoning, Peoples R China.
   [Sun, Xiaohui; Li, Xiaobin; Dong, Xiang] Dalian Med Univ, Emergency Dept, Affiliated Hosp 1, Dalian 116011, Peoples R China.
C3 China Medical University; Dalian Medical University
RP Zhao, L (corresponding author), China Med Univ, Dept Resp Med, Shengjing Hosp, 36 Sanhao St, Shenyang 110001, Liaoning, Peoples R China.
EM lzhaoli@163.com
RI Zhao, Li/AGN-1808-2022; Dong, Xiang/ABG-9017-2022
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NR 42
TC 26
Z9 31
U1 0
U2 40
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1791-2997
EI 1791-3004
J9 MOL MED REP
JI Mol. Med. Rep.
PD JAN
PY 2015
VL 11
IS 1
BP 151
EP 158
DI 10.3892/mmr.2014.2762
PG 8
WC Oncology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Research & Experimental Medicine
GA AX0OH
UT WOS:000346651100020
PM 25352008
OA hybrid, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Matsuzawa, Y
   Lerman, A
AF Matsuzawa, Yasushi
   Lerman, Amir
TI Endothelial dysfunction and coronary artery disease: assessment,
   prognosis, and treatment
SO CORONARY ARTERY DISEASE
LA English
DT Review
DE atherosclerosis; endothelial function-guided therapy; noninvasive
ID OBSTRUCTIVE SLEEP-APNEA; POSITIVE AIRWAY PRESSURE; FLOW-MEDIATED
   DILATION; INCIDENT CARDIOVASCULAR EVENTS; OXIDATIVE STRESS;
   BRACHIAL-ARTERY; WEIGHT-LOSS; VASCULAR DYSFUNCTION; VASOMOTOR FUNCTION;
   METABOLIC SYNDROME
AB Progress in the modification of conventional coronary risk factors and lifestyle behavior has reduced the incidence of atherosclerotic coronary artery disease; nonetheless, it continues to be the leading cause of mortality in the world. This might be attributed to the defective risk stratifying and prevention strategy for coronary artery disease. In the current clinical setting, atherosclerotic coronary artery disease risk is estimated on the basis of identifying and quantifying only traditional risk factors; it does not take into consideration nontraditional risk factors. In addition, most of the prevailing therapies for atherosclerosis are targeted toward traditional risk factors rather than atherosclerosis itself. It is desirable to develop a method that can directly assess the activity of atherogenesis at every moment. Endothelial function is an integrated index of all atherogenic and atheroprotective factors present in an individual including nontraditional factors and heretofore unknown factors, and it is reported to have additional predictive value for future cardiovascular events to traditional risk factors. Moreover, endothelial function has a pivotal role in all phases of atherosclerosis, from initiation to atherothrombotic complication, and is reversible at every phase, indicating that endothelial function-guided therapies might be effective and feasible in cardiovascular practice. Thus, the introduction of endothelial function testing into clinical practice might enable us to innovate individualized cardiovascular medicine. In this review, we summarize the current knowledge on the contribution of endothelial dysfunction to atherogenesis and review the methods that assess endothelial function. Finally, we focus on the effects of major antiatherosclerotic disease therapies on endothelial function and argue the possibility of noninvasive assessment of endothelial function aiming at individualized cardiovascular medicine.
C1 [Matsuzawa, Yasushi; Lerman, Amir] Mayo Coll Med, Dept Internal Med, Div Cardiovasc Dis, Rochester, MN 55905 USA.
C3 Mayo Clinic
RP Lerman, A (corresponding author), Mayo Coll Med, Dept Internal Med, Div Cardiovasc Dis, 200 First St SW, Rochester, MN 55905 USA.
EM lerman.amir@mayo.edu
FU National Institute of Health (NIH Grants) [HL-92954, AG-31750]; Mayo
   Foundation
FX A.L. is supported by the National Institute of Health (NIH Grants
   HL-92954 and AG-31750) and the Mayo Foundation.
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NR 87
TC 187
Z9 205
U1 0
U2 24
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0954-6928
EI 1473-5830
J9 CORONARY ARTERY DIS
JI Coronary Artery Dis.
PD DEC
PY 2014
VL 25
IS 8
BP 713
EP 724
DI 10.1097/MCA.0000000000000178
PG 12
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA AT4XI
UT WOS:000344945000014
PM 25365643
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Rautiainen, S
   Lindblad, BE
   Morgenstern, R
   Wolk, A
AF Rautiainen, Susanne
   Lindblad, Birgitta Ejdervik
   Morgenstern, Ralf
   Wolk, Alicja
TI Total Antioxidant Capacity of the Diet and Risk of Age-Related Cataract
   A Population-Based Prospective Cohort of Women
SO JAMA OPHTHALMOLOGY
LA English
DT Article
ID METABOLIC SYNDROME; OXIDATIVE STRESS; HUMAN LENSES; COMPONENTS;
   EXTRACTION; PLASMA
AB IMPORTANCE To our knowledge, no previous epidemiologic study has investigated the association between all antioxidants in the diet and age-related cataract. The total antioxidant capacity (TAC) concept aims to measure the capacity from all antioxidants in the diet by also taking synergistic effects into account.
   OBJECTIVE To investigate the association between the TAC of the diet and the incidence of age-related cataract in a population-based prospective cohort of middle-aged and elderly women.
   DESIGN, SETTING, AND PARTICIPANTS Questionnaire-based nutrition survey within the prospective Swedish Mammography Cohort study, which included 30 607 women (aged 49-83 years) who were observed for age-related cataract incidence for a mean of 7.7 years.
   EXPOSURE The TAC of the diet was estimated using a database of foods analyzed with the oxygen radical absorbance capacity assay.
   MAIN OUTCOMES AND MEASURES Information on incident age-related cataract diagnosis and extraction was collected through linkage to registers in the study area.
   RESULTS There were 4309 incident cases of age-related cataracts during the mean 7.7 years of follow-up (234 371 person-years). The multivariable rate ratio in the highest quintile of the TAC of the diet compared with the lowest was 0.87 (95% CI, 0.79-0.96; P for trend = .03). The main contributors to dietary TAC in the study population were fruit and vegetables (44.3%), whole grains (17.0%), and coffee (15.1%).
   CONCLUSIONS AND RELEVANCE Dietary TAC was inversely associated with the risk of age-related cataract. Future studies examining all antioxidants in the diet in relation to age-related cataract are needed to confirm or refute our findings.
C1 [Rautiainen, Susanne; Wolk, Alicja] Karolinska Inst, Inst Environm Med, Div Nutr Epidemiol, S-17177 Stockholm, Sweden.
   [Lindblad, Birgitta Ejdervik] Univ Orebro, Orebro Univ Hosp, Dept Ophthalmol, SE-70182 Orebro, Sweden.
   [Morgenstern, Ralf] Karolinska Inst, Inst Environm Med, Div Biochem Toxicol, S-17177 Stockholm, Sweden.
C3 Karolinska Institutet; Orebro University; Karolinska Institutet
RP Rautiainen, S (corresponding author), Karolinska Inst, Inst Environm Med, Nobels Vag 13, S-17177 Stockholm, Sweden.
EM susanne.rautiainen@ki.se
RI Morgenstern, Ralf/GZH-0158-2022
OI Rautiainen, Susanne/0000-0001-7193-6082
FU Swedish Research Council/Medicine and Swedish Council for Working Life
   and Social Research, Stockholm, Sweden
FX This study was supported by the Swedish Research Council/Medicine and
   Swedish Council for Working Life and Social Research, Stockholm, Sweden.
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NR 28
TC 51
Z9 53
U1 1
U2 10
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 2168-6165
EI 2168-6173
J9 JAMA OPHTHALMOL
JI JAMA Ophthalmol.
PD MAR
PY 2014
VL 132
IS 3
BP 247
EP 252
DI 10.1001/jamaophthalmol.2013.6241
PG 6
WC Ophthalmology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Ophthalmology
GA AC8HL
UT WOS:000332774000002
PM 24370844
DA 2025-06-11
ER

PT J
AU Sun, ZC
   Mukherjee, B
   Brook, RD
   Gatts, GA
   Yang, FM
   Sun, QH
   Brook, JR
   Fan, ZJ
   Rajagopalan, S
AF Sun, Zhichao
   Mukherjee, Bhramar
   Brook, Robert D.
   Gatts, Geoffrey A.
   Yang, Fumo
   Sun, Qinghua
   Brook, Jeffrey R.
   Fan, Zhongjie
   Rajagopalan, Sanjay
TI Air-Pollution and Cardiometabolic Diseases (AIRCMD): A prospective study
   investigating the impact of air pollution exposure and propensity for
   type II diabetes
SO SCIENCE OF THE TOTAL ENVIRONMENT
LA English
DT Article
DE PM2.5; Particulate matter; Cardiometabolic disorder
ID PARTICULATE MATTER; INSULIN-RESISTANCE; BLOOD-PRESSURE; OXIDATIVE
   STRESS; FINE PARTICLES; HEALTH; INFLAMMATION; POLLUTANTS; MELLITUS;
   MODEL
AB There is a paucity of prospective cohort studies investigating the impact of environmental factors on the development of cardiometabolic (CM) disorders like type II diabetes (T2DM). The objective of the Air-Pollution and Cardiometabolic Diseases (AIRCMD) study is to investigate the impact of personal level air pollution measures [personal black carbon (BC)/sulfate measures] and ambient fine particulate matter [(PM2.5)/NO2] levels on propensity to type II diabetes in Beijing, China. Subjects with metabolic syndrome will undergo four repeated study visits within each season over a one year period following an initial screening visit. At each study visit, subjects will be monitored for sub-acute exposure to personal and ambient measures of air-pollution exposure and will undergo a series of functional CM outcomes. The primary endpoints include independent associations between integrated 5-day mean exposure to PM2.5 and BC and homeostasis model assessment of insulin resistance (HOMA-IR) measures, 24-hour mean diastolic and mean arterial pressure and endothelial-dependent vasodilatation. The secondary endpoints will explore the mechanistic explanation for a causal relationship between exposures and propensity for type II diabetes and will include additional functional outcomes such as arterial compliance, heart rate variability and plasma adipokines. The novel aspects of the study include the launch of infrastructure for future translational investigations in highly polluted urbanized environments and the creation of novel methodologies for linking personalized exposure measurements with functional CM outcomes. We believe that AIRCMD will allow for unprecedented new investigations into the association between environmental risk factors and CM disorders. (C) 2012 Elsevier B.V. All rights reserved.
C1 [Sun, Zhichao; Mukherjee, Bhramar] Univ Michigan, Dept Biostat, Ann Arbor, MI 48109 USA.
   [Brook, Robert D.] Univ Michigan, Div Cardiovasc Med, Ann Arbor, MI 48109 USA.
   [Gatts, Geoffrey A.; Sun, Qinghua; Rajagopalan, Sanjay] Ohio State Univ, Coll Med, Davis Heart & Lung Res Inst, Columbus, OH 43210 USA.
   [Yang, Fumo] Chinese Acad Sci, Grad Univ, Coll Earth Sci, Key Lab Computat Geodynam, Beijing, Peoples R China.
   [Brook, Robert D.; Fan, Zhongjie] Peking Union Med Coll Hosp, Dept Cardiol, Beijing, Peoples R China.
   [Brook, Robert D.; Fan, Zhongjie] Chinese Acad Med Sci, Beijing 100730, Peoples R China.
   [Brook, Jeffrey R.] Environm Canada, Air Qual Res Div, Downsview, ON, Canada.
C3 University of Michigan System; University of Michigan; University of
   Michigan System; University of Michigan; University System of Ohio; Ohio
   State University; Chinese Academy of Sciences; University of Chinese
   Academy of Sciences, CAS; Chinese Academy of Medical Sciences - Peking
   Union Medical College; Peking Union Medical College Hospital; Chinese
   Academy of Medical Sciences - Peking Union Medical College; Environment
   & Climate Change Canada
RP Mukherjee, B (corresponding author), Univ Michigan, Dept Biostat, Ann Arbor, MI 48109 USA.
EM zhjfan@hotmail.com; Sanjay.rajagopalan@osumc.edu
RI Sun, Zhichao/I-2537-2019; Sun, Qinghua/E-4167-2011
OI Sun, Zhichao/0000-0003-3246-9746
FU NIEHS [R01ES017290, R01ES015146, R01ES019616]
FX This work was supported by NIEHS grants R01ES017290, R01ES015146 and
   R01ES019616.
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NR 34
TC 35
Z9 38
U1 4
U2 86
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0048-9697
EI 1879-1026
J9 SCI TOTAL ENVIRON
JI Sci. Total Environ.
PD MAR 15
PY 2013
VL 448
SI SI
BP 72
EP 78
DI 10.1016/j.scitotenv.2012.10.087
PG 7
WC Environmental Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology
GA 133IS
UT WOS:000318132700009
PM 23182147
OA Bronze, Green Accepted
DA 2025-06-11
ER

PT J
AU Jin, HY
   Kim, SH
   Yu, HM
   Baek, HS
   Park, TS
AF Jin, Heung Yong
   Kim, Sun Hee
   Yu, Hea Min
   Baek, Hong Sun
   Park, Tae Sun
TI Therapeutic Potential of Dioscorea Extract (DA-9801) in
   Comparison with Alpha Lipoic Acid on the Peripheral Nerves in
   Experimental Diabetes
SO JOURNAL OF DIABETES RESEARCH
LA English
DT Article
ID GROWTH-FACTOR; METABOLIC SYNDROME; NIPPONICA MAKINO; OXIDATIVE STRESS;
   NEUROPATHIC PAIN; PHOSPHORYLATION; POLYNEUROPATHY; COMPLICATIONS
AB DA-9801, a mixture of extracts from Dioscorea japonica Thunb. and Dioscorea nipponica Makino, was reported to have neurotrophic activity. Therefore, we investigated the therapeutic potential of DA-9801, in comparison with alpha lipoic acid (ALA), for peripheral nerves preservation in experimental diabetes. Experimental animals were divided into 4 groups, and each group was designated according to the type of treatment administered as follows: normal, DM, DM+DA-9801, and DM+ALA. After 16 weeks, response thresholds to tactile and thermal stimuli were higher in DM+DA-9801 group than in nontreated DM group. This degree of increase in DM+DA-9801 group indicates more therapeutic potency of DA-9801 than ALA. Western blot analysis showed more significant increase in NGF and decrease in TNF-alpha and IL-6 in DM+DA-9801 group than in DM or DM+ALA groups (P < 0.05). IENF density was reduced less significantly in the DM+DA-9801 group than in other DM groups (7.61 +/- 0.32, 4.2 +/- 0.26, and 6.5 +/- 0.30 in DM+DA-9801, DM, and DM+ALA, resp., P < 0.05). Mean myelinated axonal area in the sciatic nerves was significantly greater in DM+DA-9801 group than in other DM groups (69.2 +/- 5.76, 54.0 +/- 6.32, and 63.1 +/- 5.41 in DM+DA-9801, DM, and DM+ALA, resp., P < 0.05). Results of this study demonstrated potential therapeutic applications of DA-9801 for the treatment of diabetic peripheral neuropathy.
C1 [Jin, Heung Yong; Kim, Sun Hee; Baek, Hong Sun; Park, Tae Sun] Chonbuk Natl Univ, Sch Med, Chonbuk Natl Univ Hosp,Div Endocrinol & Metab, Biomed Res Inst,Res Inst Clin Med,Dept Internal M, Jeonju 561712, South Korea.
   [Yu, Hea Min] Eulji Univ, Eulji Univ Hosp, Res Inst Clin Med, Div Endocrinol & Metab,Dept Internal Med, Taejon, South Korea.
C3 Jeonbuk National University; Jeonbuk National University Hospital; Eulji
   University; Eulji University Hospital
RP Park, TS (corresponding author), Chonbuk Natl Univ, Sch Med, Chonbuk Natl Univ Hosp,Div Endocrinol & Metab, Biomed Res Inst,Res Inst Clin Med,Dept Internal M, 634-18 Keum Am Dong, Jeonju 561712, South Korea.
EM mdjinhy@hanmail.net
RI Kim, Sun-Hee/GXG-3355-2022
OI Yu, Hea Min/0000-0001-9731-955X
FU Global Leading Technology Program of the Office of Strategic R&D
   Planning (OSP); Ministry of Knowledge Economy (MKE), Republic of Korea;
   Research Institute of Clinical Medicine of Chonbuk National
   University-Biomedical Research Institute of Chonbuk National University
   Hospital
FX This research was partly supported by a grant from the Global Leading
   Technology Program of the Office of Strategic R&D Planning (OSP) funded
   by the Ministry of Knowledge Economy (MKE), Republic of Korea. And the
   authors thank the Research Institute of Clinical Medicine of Chonbuk
   National University-Biomedical Research Institute of Chonbuk National
   University Hospital for supporting our researches in a grant partly and
   experimental system.
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NR 32
TC 13
Z9 14
U1 0
U2 14
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2314-6745
EI 2314-6753
J9 J DIABETES RES
JI J. Diabetes Res.
PY 2013
VL 2013
AR 631218
DI 10.1155/2013/631218
PG 10
WC Endocrinology & Metabolism; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Research & Experimental Medicine
GA 140DI
UT WOS:000318634100001
PM 23671883
OA Green Submitted, gold, Green Published
DA 2025-06-11
ER

PT J
AU Vamecq, J
   Dessein, AF
   Fontaine, M
   Briand, G
   Porchet, N
   Latruffe, N
   Andreolotti, P
   Cherkaoui-Malki, M
AF Vamecq, Joseph
   Dessein, Anne-Frederique
   Fontaine, Monique
   Briand, Gilbert
   Porchet, Nicole
   Latruffe, Norbert
   Andreolotti, Pierre
   Cherkaoui-Malki, Mustapha
TI Mitochondrial Dysfunction and Lipid Homeostasis
SO CURRENT DRUG METABOLISM
LA English
DT Review
DE ATP; calcium; ceramides; fatty acids; lipotoxicity; metabolic syndrome;
   mitochondria; reactive oxygen species
ID FATTY-ACID SYNTHASE; BREAST-CANCER CELLS; HYPOTHALAMIC MALONYL-COA;
   LOW-DENSITY-LIPOPROTEIN; OXIDATIVE STRESS; MOLECULAR-MECHANISMS;
   ENDOPLASMIC-RETICULUM; ANTIOXIDANT DEFENSE; INSULIN-RESISTANCE; BINDING
   PROTEIN
AB This review is aimed at illustrating that mitochondrial dysfunction and altered lipid homeostasis may concur in a variety of pathogenesis states, being either contributive or consecutive to primary disease events. Underlying mechanisms for this concurrence are far from being the exhaustive elements taking place in disease development. They may however complicate, contribute or cause the disease. In the first part of the review, physiological roles of mitochondria in coordinating lipid metabolism and in controlling reactive oxygen species (ROS), ATP and calcium levels are briefly presented. In a second part, clues for how mitochondria-driven alterations in lipid metabolism may induce toxicity are discussed. In the third part, it is illustrated how mitochondrial dysfunction and lipid homeostasis disruption may be associated (i) to complicate type 1 diabetes (pancreatic beta-cell mitochondrial dysfunction in ATP yield induces reduced insulin secretion and hence disruption of glucose and lipid metabolism), (ii) to contribute to type 2 diabetes and other insulin resistant states (mitochondrial impairment may induce adipocyte dysfunction with subsequent increase in circulating free fatty acids and their abnormal deposit in non adipose tissues (pancreatic beta-cells, skeletal muscle and liver) which results in lipotoxicity and mitochondrial dysfunction), (iii) to offer new clues in our understanding of how the brain controls feeding supply and energy expenditure, (iv) to promote cancer development notably via fatty acid oxidation/synthesis imbalance (in favor of synthesis) further strengthened in some cancers by a lipogenetic benefit induced by a HER2/fatty acid synthase cross-talk, and (v) to favor cardiovascular disorders by impacting heart function and arterial wall integrity.
C1 [Vamecq, Joseph] CHRU Lille, INSERM, Lab Ext, F-59037 Lille, France.
   [Vamecq, Joseph; Dessein, Anne-Frederique; Fontaine, Monique; Briand, Gilbert; Porchet, Nicole] CHRU Lille, Dept Biochem & Mol Biol, Lab Hormonol Metab Nutr & Oncol HMNO, Ctr Biol & Pathol Pierre Marie Degand CBP, F-59037 Lille, France.
   [Vamecq, Joseph] Univ Mons UMons, Dept Dean, Fac Med & Pharm, Mons, Belgium.
   [Briand, Gilbert] Univ Lille 2, Mass Spectrometry Applicat Lab, F-59045 Lille, France.
   [Latruffe, Norbert; Andreolotti, Pierre; Cherkaoui-Malki, Mustapha] INSERM, UMR 866, F-21000 Dijon, France.
   [Latruffe, Norbert; Andreolotti, Pierre; Cherkaoui-Malki, Mustapha] Univ Bourgogne, Ctr Rech Biochim Metab & Nutr LBMN, CNRS, GDR 2583, F-21000 Dijon, France.
C3 Universite de Lille; CHU Lille; Institut National de la Sante et de la
   Recherche Medicale (Inserm); Universite de Lille; CHU Lille; University
   of Mons; Universite de Lille; Institut Agro; AgroSup Dijon; Universite
   Bourgogne Europe; Institut National de la Sante et de la Recherche
   Medicale (Inserm); Universite Bourgogne Europe; Centre National de la
   Recherche Scientifique (CNRS)
RP Vamecq, J (corresponding author), CHRU Lille, INSERM, Lab Ext, F-59037 Lille, France.
EM joseph.vamecq@inserm.fr
RI Cherkaoui-Malki, Mustapha/B-2412-2012; Andreoletti, Pierre/B-5245-2012;
   Vamecq, Joseph/M-4953-2018
OI Andreoletti, Pierre/0000-0003-2118-7858; Vamecq,
   Joseph/0000-0002-4089-7663; Dessein, Anne-Frederique/0000-0003-1713-0402
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NR 114
TC 50
Z9 57
U1 0
U2 47
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1389-2002
EI 1875-5453
J9 CURR DRUG METAB
JI Curr. Drug Metab.
PD DEC
PY 2012
VL 13
IS 10
BP 1388
EP 1400
DI 10.2174/138920012803762792
PG 13
WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
GA 052NC
UT WOS:000312203600004
PM 22978394
DA 2025-06-11
ER

PT J
AU Hung, CL
   Wu, YJ
   Liu, CC
   Chi, BC
   Chang, SS
   Wang, LY
   Yeh, HI
   Wei, YH
AF Hung, Chung-Lieh
   Wu, Yih-Jer
   Liu, Chun-Chieh
   Chi, Bo-Chin
   Chang, Sheng-Shiung
   Wang, Li-Yu
   Yeh, Hung-I.
   Wei, Yau-Huei
CA MAGNET Study Investigators
TI Rationale and Design of MAGNET (Mitochondria-AGing in North Ern Taiwan)
   Study: A Community-based Cohort Investigating Mitochondria-related Aging
   and Cardiovascular Diseases in Suburban Areas of Northern Taiwan
SO INTERNATIONAL JOURNAL OF GERONTOLOGY
LA English
DT Article
DE aging; cardiovascular diseases; cohort study; endothelial progenitor
   cells; mitochondria
ID ENDOTHELIAL DYSFUNCTION; ARTERIAL STIFFNESS; METABOLIC SYNDROME;
   OXIDATIVE STRESS; AGE; HEART; RISK; ATHEROSCLEROSIS; HYPERTENSION;
   SUPEROXIDE
AB Background: Aging is known to play a key role in the development of cardiovascular diseases (CVDs). Although aging is associated with mitochondria dysfunction, the impact of mitochondria-related aging on CVDs has remained unclear in Taiwan.
   Methods: The Mitochondria-AGing in NorthErn Taiwan (MAGNET) study, a prospective study, was initiated in December 2010 to investigate the prevalence, determinants and the progress of CVDs and related risks in a community-dwelling sample of about 3000 men and women from suburban areas of northern Taiwan. The middle-aged population comprises the majority of the whole cohort in a 3-year collection period. This study also examines a link between baseline characteristics and the development of subclinical atherosclerosis. Data obtained will include information regarding baseline demographics, body surface electrocardiography, blood bio-specimen components, measurement of cardiac and carotid structure and function by ultrasonography, socioeconomic status, life styles, and life quality scoring including short-form SF-36. Additional survey of blood samples, including analysis of endothelial progenitor cells and the mitochondria function, and biomarkers, for a nested case-control study will be performed. All participants will be followed for incidence and characterization of related cardiovascular events.
   Conclusion: This study is expected to clarify the role of mitochondria-related aging in the development of CVDs and functional changes in sub-urban areas of Taiwan. Copyright (c) 2012, Taiwan Society of Geriatric Emergency & Critical Care Medicine. Published by Elsevier Taiwan LLC. All rights reserved.
C1 [Wu, Yih-Jer; Wang, Li-Yu; Yeh, Hung-I.; Wei, Yau-Huei] Mackay Med Coll, Dept Med, San Jhih District 25245, New Taipei, Taiwan.
   [Hung, Chung-Lieh; Wu, Yih-Jer; Liu, Chun-Chieh; Chi, Bo-Chin; Chang, Sheng-Shiung; Yeh, Hung-I.] Mackay Mem Hosp, Dept Internal Med, New Taipei, Taiwan.
C3 Mackay Medical College; Mackay Memorial Hospital
RP Wang, LY (corresponding author), Mackay Med Coll, Dept Med, 46,Sect 3,Jhong Jheng Road, San Jhih District 25245, New Taipei, Taiwan.
EM yannbo@mmc.edu.tw
RI Wei, Yau-Huei/ABA-6841-2021; huang, wenyu/HTQ-5747-2023; Fu,
   Hung-Chun/AAT-3922-2020; Qi, Wang/KEI-7047-2024
OI Wei, Yau-Huei/0000-0002-6429-2546
FU National Science Council; Mackay Medical College; Mackay Memorial
   Hospital
FX Supported by National Science Council, Mackay Medical College, and
   Mackay Memorial Hospital. Study members and Investigators in the
   Mitochondria-AGing in NorthErn Taiwan (MAGNET) study: Mackay Medical
   College: Yau-Huei Wei, Hung-I Yeh, Li-Yu Wang, Yih-Jer Wu, Joyce C.
   Chen, Shwun-De Wang, Shih-Wei Wang, Tzu-Wei Wu. Mackay Memorial Hospital
   (Physicians): Chung-Lieh Hung, Jell-Yuan Kuo, Chun-Chieh Liu, Chi
   Po-Ching, Sheng-Hsiung Chang, Chi-In Lo, Hsiang-Wei Yang, Zhen-Yu Liao,
   Chih-Hsuan Yen, Jui-Pen Tsai, Wei-Wen Lin, Yau-Huei Lai, Yen-Yu Liu,
   Tsung-Yeh Yang. Mackay Memorial Hospital (Technicians): Hsiu-O Wu,
   Hsin-Ying Chen, Shu-Fen Wang, Pai-Yu Pan, Chiu-Ni Lai, Tzu-Ling Huang.
   Ultrasound Reading Center - Department of Cardiology: Mackay Memorial
   Hospital, Chung-Lieh Hung; Instrument Center - Office of Research and
   Development, Mackay Medical College; Project Office - Department of
   Medicine, Mackay Medical College: Mei-Chu Chen, Cheng-Min Kang, Wen-Ting
   Liu, Tsai-Ting Wang, Juei-Yu Yen.
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NR 33
TC 6
Z9 6
U1 0
U2 3
PU ELSEVIER TAIWAN
PI TAIPEI
PA RM N-412, 4F, CHIA HSIN BUILDING 11, NO 96, ZHONG SHAN N ROAD SEC 2,
   TAIPEI, 10449, TAIWAN
SN 1873-9598
EI 1873-958X
J9 INT J GERONTOL
JI Int. J. Gerontol.
PD JUN
PY 2012
VL 6
IS 2
BP 122
EP 126
DI 10.1016/j.ijge.2012.05.014
PG 5
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA 985JU
UT WOS:000307261300012
OA Bronze
DA 2025-06-11
ER

PT J
AU Nadal-Casellas, A
   Proenza, AM
   Lladó, I
   Gianotti, M
AF Nadal-Casellas, Antonia
   Proenza, Ana M.
   Llado, Isabel
   Gianotti, Magdalena
TI Effects of ovariectomy and 17-β estradiol replacement on rat brown
   adipose tissue mitochondrial function
SO STEROIDS
LA English
DT Article
DE Brown adipose tissue; 17-beta estradiol replacement; Mitochondria;
   Ovariectomy; Rat; Sex
ID FACTOR-A TFAM; OXIDATIVE STRESS; TRANSCRIPTION-FACTOR; OVARIAN HORMONES;
   SKELETAL-MUSCLE; STIMULATES TRANSCRIPTION; METABOLIC SYNDROME;
   ENERGY-BALANCE; CYTOCHROME-C; OBESE RATS
AB Taking into account the sexual dimorphism previously reported regarding mitochondrial function and biogenesis in brown adipose tissue, the aim of the present study was to go further into these differences by investigating the effect of ovariectomy and 17-beta estradiol (E2) replacement on brown adipose tissue mitochonclrial function. In this study, fourteen-week-old control female and ovariectomized female Wistar rats were used. Rats were ovariectomized at 5 weeks of age and were treated every 2 days with placebo (OVX group) or E2 (10 mu g/kg)(OVX + E2 group) for 4 weeks before sacrifice. We studied the levels of oxidative capacity, antioxidant defence and oxidative damage markers in brown adipose tissue. Moreover, the levels of key elements of mitochondrial biogenesis as well as UCP1 protein levels, as an index of mitochondrial thermogenic capacity, were also determined. In response to ovariectomy, mitochondrial proliferation increased, resulting in less functional mitochondria, since oxidative capacity and antioxidant defences decreased. Although E2 supplementation was able to restore the serum levels of E2 shown by control rats, the treatment reverted the effects of the ovariectomy only in part, and oxidative and antioxidant capacities in OVX + E2 rats did not reach the levels shown by control females. Taking these results into account, we suggest that ovarian hormones are responsible, at least in part, for the sexual dimorphism in BAT mitochondrial function. However, other signals produced by ovary, rather than E2 would play an important role in the control of mitochondrial function in BAT. (C) 2011 Elsevier Inc. All rights reserved.
C1 [Nadal-Casellas, Antonia; Proenza, Ana M.; Llado, Isabel; Gianotti, Magdalena] Univ Illes Balears, Dept Biol Fonamental & Ciencies Salut, IUNICS, Grp Metabolisme Energet & Nutr, E-07122 Palma de Mallorca, Spain.
   [Nadal-Casellas, Antonia; Proenza, Ana M.; Llado, Isabel; Gianotti, Magdalena] Inst Salud Carlos III, Madrid, Spain.
C3 Universitat de les Illes Balears; IUNICS; Instituto de Salud Carlos III
RP Gianotti, M (corresponding author), Univ Illes Balears, Dept Biol Fonamental & Ciencies Salut, IUNICS, Grp Metabolisme Energet & Nutr, Cra Valldemossa Km 7-5, E-07122 Palma de Mallorca, Spain.
EM antonia.nadal@uib.es; ana.proenza@uib.es; isabel.llado@uib.es;
   magdalena.gianotti@uib.es
RI Gianotti, Magdalena/H-7725-2015; Proenza, Ana Maria/L-3383-2014; Llado,
   Isabel/I-1540-2015
OI Gianotti, Magdalena/0000-0002-5225-9079; Proenza, Ana
   Maria/0000-0001-8153-5442; Llado, Isabel/0000-0003-2023-1191
FU Fondo de Investigaciones Sanitarias of the Spanish Government
   [PI060293]; Conselleria d'Innovacio i Energia of the Comunitat Autonoma
   de les Illes Balears [PROGECIB-1C]; Comunitat Autonoma de les Illes
   Balears
FX We thank Dr. Hidetoshi Inagaki for providing the antiserum against TFAM.
   This work was supported by Fondo de Investigaciones Sanitarias of the
   Spanish Government (PI060293) and by Conselleria d'Innovacio i Energia
   of the Comunitat Autonoma de les Illes Balears (PROGECIB-1C). A.
   Nadal-Casellas was funded by a grant from the Comunitat Autonoma de les
   Illes Balears.
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NR 61
TC 29
Z9 32
U1 0
U2 6
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0039-128X
J9 STEROIDS
JI Steroids
PD SEP-OCT
PY 2011
VL 76
IS 10-11
BP 1051
EP 1056
DI 10.1016/j.steroids.2011.04.009
PG 6
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 809RP
UT WOS:000294074700015
PM 21540046
DA 2025-06-11
ER

PT J
AU Xu, XH
   Yavar, ZB
   Verdin, M
   Ying, ZK
   Mihai, G
   Kampfrath, T
   Wang, AX
   Zhong, MH
   Lippmann, M
   Chen, LC
   Rajagopalan, S
   Sun, QH
AF Xu, Xiaohua
   Yavar, Zubin
   Verdin, Matt
   Ying, Zhekang
   Mihai, Georgeta
   Kampfrath, Thomas
   Wang, Aixia
   Zhong, Mianhua
   Lippmann, Morton
   Chen, Lung-Chi
   Rajagopalan, Sanjay
   Sun, Qinghua
TI Effect of Early Particulate Air Pollution Exposure on Obesity in Mice
   Role of p47<SUP>phox</SUP>
SO ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
LA English
DT Article
DE PM2.5 air pollution; obesity; NADPH oxidase; inflammation; insulin
   resistance
ID AMBIENT PARTICLES CAPS; INDUCED INSULIN-RESISTANCE; OXIDASE SUBUNIT
   P47(PHOX); DIET-INDUCED OBESITY; LONG-TERM EXPOSURE; SUBCHRONIC
   EXPOSURES; NADPH OXIDASE; ADIPOSE-TISSUE; CARDIOVASCULAR RISK;
   METABOLIC-SYNDROME
AB Objective-To evaluate the role of early-life exposure to airborne fine particulate matter (diameter, < 2.5 mu m [PM2.5]) pollution on metabolic parameters, inflammation, and adiposity; and to investigate the involvement of oxidative stress pathways in the development of metabolic abnormalities.
   Methods and Results-PM2.5 inhalation exposure (6 h/d, 5 d/wk) was performed in C57BL/6 mice (wild type) and mice deficient in the cytosolic subunit of the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase p47(phox) (p47(phox-/-)) beginning at the age of 3 weeks for a duration of 10 weeks. Both groups were simultaneously fed a normal diet or a high-fat diet for 10 weeks. PM2.5-exposed C57BL/6 mice fed a normal diet exhibited metabolic abnormalities after exposure to PM2.5 or FA for 10 weeks. Consistent with insulin resistance, these abnormalities included enlarged subcutaneous and visceral fat contents, increased macrophage infiltration in visceral adipose tissue, and vascular dysfunction. Ex vivo-labeled and infused monocytes demonstrated increased adherence in the microcirculation of normal diet-or high-fat diet-fed PM2.5-exposed mice. p47(phox-/-) mice exhibited an improvement in parameters of insulin resistance, vascular function, and visceral inflammation in response to PM2.5.
   Conclusion-Early-life exposure to high levels of PM2.5 is a risk factor for subsequent development of insulin resistance, adiposity, and inflammation. Reactive oxygen species generation by NADPH oxidase appears to mediate this risk. (Arterioscler Thromb Vasc Biol. 2010;30:2518-2527.)
C1 [Xu, Xiaohua; Yavar, Zubin; Verdin, Matt; Sun, Qinghua] Ohio State Univ, Coll Publ Hlth, Div Environm Hlth Sci, Columbus, OH 43210 USA.
   [Yavar, Zubin; Mihai, Georgeta; Kampfrath, Thomas; Wang, Aixia; Rajagopalan, Sanjay] Ohio State Univ, Davis Heart & Lung Res Inst, Columbus, OH 43210 USA.
   [Zhong, Mianhua; Lippmann, Morton; Chen, Lung-Chi] NYU, Sch Med, Dept Environm Med, Tuxedo Pk, NY USA.
   [Rajagopalan, Sanjay; Sun, Qinghua] Ohio State Univ, Coll Med, Div Cardiovasc Med, Columbus, OH 43210 USA.
C3 University System of Ohio; Ohio State University; University System of
   Ohio; Ohio State University; New York University; University System of
   Ohio; Ohio State University
RP Sun, QH (corresponding author), Ohio State Univ, Coll Publ Hlth, Div Environm Hlth Sci, Biomed Res Tower Room 396,460 W 12th Ave, Columbus, OH 43210 USA.
EM sun.224@osu.edu
RI Sun, Qinghua/E-4167-2011
OI Chen, Lung Chi/0000-0003-1154-2107
FU Diabetes Action Research and Education Foundation [268]; National
   Institutes of Health [RO1 ES015146, R21 ES017412, K01 ES016588]
FX This study was supported by the Diabetes Action Research and Education
   Foundation (# 268); and grants RO1 ES015146 (Dr Rajagopalan) and R21
   ES017412 and K01 ES016588 (Dr Sun) from the National Institutes of
   Health.
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NR 55
TC 256
Z9 280
U1 0
U2 56
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1079-5642
J9 ARTERIOSCL THROM VAS
JI Arterioscler. Thromb. Vasc. Biol.
PD DEC
PY 2010
VL 30
IS 12
BP 2518
EP U357
DI 10.1161/ATVBAHA.110.215350
PG 28
WC Hematology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Hematology; Cardiovascular System & Cardiology
GA 681JU
UT WOS:000284309000038
PM 20864666
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Tang, YC
   Chen, AP
AF Tang, Youcai
   Chen, Anping
TI Curcumin Protects Hepatic Stellate Cells against Leptin-Induced
   Activation in Vitro by Accumulating Intracellular Lipids
SO ENDOCRINOLOGY
LA English
DT Article
ID EXTRACELLULAR-MATRIX GENES; TYPE-2 DIABETES-MELLITUS; TISSUE
   GROWTH-FACTOR; PPAR-GAMMA; RECEPTOR-GAMMA; METABOLIC SYNDROME; COLLAGEN
   PRODUCTION; 3T3-L1 ADIPOCYTES; OXIDATIVE STRESS; CANCER-CELLS
AB Obesity and type II diabetes mellitus are often associated with hyperleptinemia and commonly accompanied by nonalcoholic steatohepatitis, which could cause hepatic fibrosis. During hepatic fibrogenesis, the major effectors hepatic stellate cells (HSCs) become active, coupling with depletion of cellular lipid droplets and downexpression of genes relevant to lipid accumulation. Accumulating evidence supports the proposal that recovering the accumulation of lipids would inhibit HSC activation. We recently reported that leptin stimulated HSC activation, which was eliminated by curcumin, a phytochemical from turmeric. The current study was designed to explore the underlying mechanisms, focusing on their effects on the level of intracellular lipids. We hypothesized that one of the mechanisms by which leptin stimulated HSC activation was to stimulate the depletion of intracellular lipids, which could be abrogated by curcumin by inducing expression of genes relevant to lipid accumulation. In this report, we observed that leptin dose dependently reduced levels of intracellular fatty acids and triglycerides in passaged HSCs, which were eliminated by curcumin. The phytochemical abrogated the impact of leptin on inhibiting the activity of AMP-activated protein kinase (AMPK) in HSCs in vitro. The activation of AMPK resulted in inducing expression of genes relevant to lipid accumulation and increasing intracellular lipids in HSCs in vitro. In summary, curcumin eliminated stimulatory effects of leptin on HSC activation and increased AMPK activity, leading to inducing expression of genes relevant to lipid accumulation and elevating the level of intracellular lipids. These results provide novel insights into mechanisms of curcumin in inhibiting leptin-induced HSC activation. (Endocrinology 151: 4168-4177, 2010)
C1 [Chen, Anping] St Louis Univ, Sch Med, Dept Pathol, Edward A Doisy Res Ctr, St Louis, MO 63104 USA.
   [Tang, Youcai] Zhengzhou Univ, Affiliated Hosp 3, Dept Pediat, Zhengzhou 450052, Henan, Peoples R China.
C3 Saint Louis University; Zhengzhou University
RP Chen, AP (corresponding author), St Louis Univ, Sch Med, Dept Pathol, Edward A Doisy Res Ctr, 1100 S Grand Blvd,Room 215, St Louis, MO 63104 USA.
EM achen5@slu.edu
RI Chen, An-Ping/I-6455-2013; Tang, Youcai/C-4480-2012
OI Tang, Youcai/0000-0003-2087-6029
FU National Institutes of Health/National Institute of Diabetes and
   Digestive and Kidney Diseases [RO1 DK 047995]
FX This work was supported by the National Institutes of Health/National
   Institute of Diabetes and Digestive and Kidney Diseases Grant RO1 DK
   047995 (to A.C.).
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NR 54
TC 56
Z9 64
U1 0
U2 7
PU ENDOCRINE SOC
PI CHEVY CHASE
PA 8401 CONNECTICUT AVE, SUITE 900, CHEVY CHASE, MD 20815-5817 USA
SN 0013-7227
J9 ENDOCRINOLOGY
JI Endocrinology
PD SEP
PY 2010
VL 151
IS 9
BP 4168
EP 4177
DI 10.1210/en.2010-0191
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 642WP
UT WOS:000281252000013
PM 20660066
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Grassi, G
   Seravalle, G
   Scopelliti, F
   Dell'Oro, R
   Fattori, L
   Quarti-Trevano, F
   Brambilla, G
   Schiffrin, EL
   Mancia, G
AF Grassi, Guido
   Seravalle, Gino
   Scopelliti, Francesco
   Dell'Oro, Raffaella
   Fattori, Luca
   Quarti-Trevano, Fosca
   Brambilla, Gianmaria
   Schiffrin, Ernesto L.
   Mancia, Giuseppe
TI Structural and Functional Alterations of Subcutaneous Small Resistance
   Arteries in Severe Human Obesity
SO OBESITY
LA English
DT Article
ID ENDOTHELIAL DYSFUNCTION; CARDIOVASCULAR EVENTS; INSULIN SENSITIVITY;
   METABOLIC SYNDROME; RECEPTOR BLOCKER; AMSTERDAM GROWTH; FAT
   DISTRIBUTION; HYPERTENSION; STIFFNESS; ACTIVATION
AB Obese persons are at increased cardiovascular risk and exhibit increased arterial stiffness and impaired endothelial function of large- and medium-size arteries. We hypothesized that normotensive subjects suffering from severe obesity would also present remodeling and endothelial dysfunction of small resistance arteries. A total of 16 lean (age: 49.6 +/- 2.9 years, BMI: 22.9 +/- 0.3 kg/m(2), mean +/- s.e.m.) and 17 age-matched severely obese (BMI: 41.1 +/- 2.3 kg/m(2)) normotensive subjects were investigated. None had glucose or lipid metabolic abnormalities except for insulin resistance. Resistance arteries, dissected from abdominal subcutaneous tissue, were assessed on a pressurized myograph. For superimposable blood pressure, the media thickness, media cross-sectional area (CSA), and media-to-lumen ratio values of resistance arteries were markedly and significantly greater in obese compared to lean subjects (media thickness 26.3 +/- 0.6 vs. 16.2 +/- 0.6 mu m, CSA 22,272 +/- 1,339 vs. 15,183 +/- 1,186 mu m(2), and media-to-lumen ratio 0.113 +/- 0.006 vs. 0.059 +/- 0.001, respectively, P < 0.01). Acetylcholine-induced relaxation was impaired in vessels from obese subjects compared to the lean individuals (-40.4 +/- 1.3%, P < 0.01), whereas endothelium-independent vasorelaxation was similar in all groups. Stiffness of small arteries as assessed by the stress/strain relationship was similar in lean and severely obese subjects. We conclude that severe human obesity is associated with profound alterations in structural and functional characteristics of small arteries, which may be responsible for the presence of elevated cardiovascular risk and increased incidence of coronary, cerebrovascular and renal events reported in obesity.
C1 [Grassi, Guido; Dell'Oro, Raffaella; Quarti-Trevano, Fosca; Mancia, Giuseppe] Univ Milano Bicocca, Med Clin, Dipartimento Med Clin Prevenz & Biotecnol Sanit, Osped San Gerardo, Milan, Italy.
   [Grassi, Guido; Seravalle, Gino; Mancia, Giuseppe] Ist Auxol Italiano, Milan, Italy.
   [Scopelliti, Francesco; Brambilla, Gianmaria] IRCCS, Ist Sci Multimed, Milan, Italy.
   [Fattori, Luca] Univ Milano Bicocca, Osped San Gerardo, Clin Chirurg, Milan, Italy.
   [Schiffrin, Ernesto L.] McGill Univ, Jewish Gen Hosp, SMBD, Dept Med, Montreal, PQ H3T 1E2, Canada.
C3 San Gerardo Hospital; University of Milano-Bicocca; IRCCS Istituto
   Auxologico Italiano; San Gerardo Hospital; University of Milano-Bicocca;
   Jewish General Hospital - Montreal; McGill University
RP Grassi, G (corresponding author), Univ Milano Bicocca, Med Clin, Dipartimento Med Clin Prevenz & Biotecnol Sanit, Osped San Gerardo, Milan, Italy.
EM guido.grassi@unimib.it
RI Santilli, Francesca/ABC-6243-2021; MANCIA, GIUSEPPE/AGF-9410-2022;
   Schiffrin, Ernesto/AAB-9061-2019; seravalle, gino/K-1442-2019
OI seravalle, gino/0000-0003-3638-8011; Schiffrin,
   Ernesto/0000-0002-4502-2823
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NR 40
TC 93
Z9 98
U1 0
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1930-7381
EI 1930-739X
J9 OBESITY
JI Obesity
PD JAN
PY 2010
VL 18
IS 1
BP 92
EP 98
DI 10.1038/oby.2009.195
PG 7
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 538UU
UT WOS:000273210400014
PM 19521345
OA Bronze
DA 2025-06-11
ER

PT S
AU Virmani, A
   Ali, SF
   Binienda, ZK
AF Virmani, Ashraf
   Ali, Syed F.
   Binienda, Zbigniew K.
BE Andrews, RJ
   Slikker, W
   Trembly, B
   Patterson, TA
TI Neuroprotective strategies in drug abuse-evoked encephalopathy
SO NEUROPROTECTIVE AGENTS
SE Annals of the New York Academy of Sciences
LA English
DT Article; Proceedings Paper
CT 9th International Conference on Neuroprotective Agents
CY SEP 07-11, 2008
CL Marine Biol Lab, Woods Hole, MA
HO Marine Biol Lab
DE leucoencephalopathy; nutrition; neurotoxicity; drug-abuse; cocaine;
   methamphetamine; alcohol; amphetamines
ID METHAMPHETAMINE-INDUCED NEUROTOXICITY; INDUCED DOPAMINERGIC
   NEUROTOXICITY; ACETYL-L-CARNITINE; TOXIC LEUKOENCEPHALOPATHY; METABOLIC
   SYNDROME; OXIDATIVE STRESS; NEURONAL APOPTOSIS; COCAINE TOXICITY;
   GENE-EXPRESSION; MOUSE-BRAIN
AB Encephalopathy is evidenced as an altered mental state with various neurological symptoms, such as memory and cognitive problems. The type of a substance-evoked encephalopathy will depend on the drug, substance, or combination being abused. The categories into which we could place the various abused substances could be tentatively divided into stimulants, amphetamines, hallucinogens, narcotics, inhalants, anesthetics, anabolic steroids, and antipsychotics/antidepressants. Other factors that may underlie encephalopathy, such as infectious agents, environmental, and other factors have also to be taken into account. Drugs of abuse can be highly toxic to the CNS following acute, but more so in chronic exposure, and can produce significant damage to other organs, such as the heart, lungs, liver, and kidneys. The damage to these organs may be at least partially reversible when drug abuse is stopped but CNS damage from repeated or prolonged abuse is often irreversible. The major pathways for the organ and CNS toxicity could be related to ischemic events as well as increased cell damage due to metabolic or mitochondrial dysfunction resulting in increased excitotoxicity, reduced energy production, and lowered antioxidant potential. These susceptibilities could be strengthened by the use of antioxidants to combat free radicals (e.g., vitamin E, lipoic acid); trying to improve energy generation by using mitochondriotropic/metabolic compounds (e.g., thiamine, coenzyme Q10, carnitine, riboflavin); by reducing excitotoxicity (e.g., glutamate antagonists) and other possible strategies, such as robust gene response, need to be investigated further. The drug-abuse-evoked encephalopathy still needs to be studied further to enable better preventative and protective strategies.
C1 [Virmani, Ashraf] Sigma Tau Pharmaceut Co, Sci & Med Affairs, I-00040 Pomezia, Italy.
   [Virmani, Ashraf] EMMA, London, England.
   [Virmani, Ashraf] EMMA, Rome, Italy.
   [Ali, Syed F.] US FDA, Natl Ctr Toxicol Res, Neurochem Lab, Jefferson, AR 72079 USA.
   [Binienda, Zbigniew K.] US FDA, Natl Ctr Toxicol Res, Neurophysiol Lab, Jefferson, AR 72079 USA.
C3 Leadiant Biosciences; US Food & Drug Administration (FDA); US Food &
   Drug Administration (FDA)
RP Virmani, A (corresponding author), Sigma Tau Pharmaceut Co, Via Pontina Km 30,400, I-00040 Rome, Italy.
EM ashraf.virmani@sigma-tau.it
RI Virmani, a./J-9790-2019
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NR 113
TC 15
Z9 15
U1 0
U2 16
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN STREET, MALDEN 02148, MA USA
SN 0077-8923
BN 978-1-57331-777-1
J9 ANN NY ACAD SCI
JI Ann.NY Acad.Sci.
PY 2010
VL 1199
BP 52
EP 68
DI 10.1111/j.1749-6632.2009.05171.x
PG 17
WC Multidisciplinary Sciences; Neurosciences
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics; Neurosciences & Neurology
GA BRJ59
UT WOS:000282838900006
PM 20633109
DA 2025-06-11
ER

PT J
AU Fontana, L
AF Fontana, Luigi
TI Neuroendocrine factors in the regulation of inflammation: Excessive
   adiposity and calorie restriction
SO EXPERIMENTAL GERONTOLOGY
LA English
DT Article; Proceedings Paper
CT 9th International Symposium on the Neurobiology and Neuroendocrinology
   of Aging
CY JUL 20-25, 2008
CL Bregenz, AUSTRIA
DE Obesity; Energy intake; Adipocyte; Adipokines; Neuroendocrine; Calorie
   restriction; Adiposity; Inflammation
ID CORONARY-HEART-DISEASE; C-REACTIVE PROTEIN; BLOOD MONONUCLEAR-CELLS;
   GENE-EXPRESSION PROFILE; NF-KAPPA-B; FOOD RESTRICTION; RHESUS-MONKEYS;
   WEIGHT-LOSS; METABOLIC SYNDROME; OXIDATIVE STRESS
AB Acute inflammation is usually a self-limited life preserving response, triggered by pathogens and/or traumatic injuries. This transient response normally leads to removal of harmful agents and to healing of the damaged tissues. In contrast, unchecked or chronic inflammation can lead to persistent tissue and organ damage by activated leukocytes, cytokines, or collagen deposition. Excessive energy intake and adiposity cause systemic inflammation, whereas calorie restriction without malnutrition exerts a potent anti-inflammatory effect. As individuals accumulate fat and their adipocytes enlarge, adipose tissue undergoes molecular and cellular alterations, macrophages accumulate, and inflammation ensues. Overweight/obese subjects have significantly higher plasma concentrations of C-reactive protein and several cytokines, including IL-6, IL-8, IL-18, and TNF-alpha. Experimental animals on a chronic CR regimen, instead, have low levels of circulating inflammatory cytokines, low blood lymphocyte levels, reduced production of inflammatory cytokines by the white blood cells in response to stimulation, and cortisol levels in the high normal range. Recent data demonstrate that CR exerts a powerful anti-inflammatory effect also in non-human primates and humans. Multiple metabolic and neuroendocrine mechanisms are responsible for the CR-mediated anti-inflammatory effects, including reduced adiposity and secretion of pro-inflammatory adipokines, enhanced glucocorticoid production, reduced plasma glucose and advanced glycation end-product concentrations, increased parasympathetic tone, and increased ghrelin production. Measuring tissue specific effects of CR using genomic, proteomic, and metabolomic techniques in humans will foster the understanding of the complex biological processes involved in the anti-inflammatory and anti-aging effects of CR. (c) 2008 Elsevier Inc. All rights reserved.
C1 [Fontana, Luigi] Washington Univ, Sch Med, Div Geriatr & Nutr Sci, Ctr Human Nutr, St Louis, MO 63110 USA.
   [Fontana, Luigi] Ist Super Sanita, Div Food Sci Human Nutr & Hlth, I-00161 Rome, Italy.
C3 Washington University (WUSTL); Istituto Superiore di Sanita (ISS)
RP Fontana, L (corresponding author), Washington Univ, Sch Med, Div Geriatr & Nutr Sci, Ctr Human Nutr, 4566 Scott Ave, St Louis, MO 63110 USA.
EM lfontana@im.wustl.edu
RI Fontana, Luigi/K-4773-2013
OI Fontana, Luigi/0000-0001-8500-5537
FU NCRR NIH HHS [RR00036, M01 RR000036] Funding Source: Medline; NIDDK NIH
   HHS [P30 DK056341, DK56351] Funding Source: Medline
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NR 84
TC 60
Z9 73
U1 0
U2 9
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0531-5565
J9 EXP GERONTOL
JI Exp. Gerontol.
PD JAN-FEB
PY 2009
VL 44
IS 1-2
BP 41
EP 45
DI 10.1016/j.exger.2008.04.005
PG 5
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Geriatrics & Gerontology
GA 396XA
UT WOS:000262623800007
PM 18502597
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Alatalo, PI
   Koivisto, HM
   Hietala, JP
   Puukka, KS
   Bloigu, R
   Niemelä, OJ
AF Alatalo, Paeivikki I.
   Koivisto, Heidi M.
   Hietala, Johanna P.
   Puukka, Katri S.
   Bloigu, Risto
   Niemelae, Onni J.
TI Effect of moderate alcohol consumption on liver enzymes increases with
   increasing body mass index
SO AMERICAN JOURNAL OF CLINICAL NUTRITION
LA English
DT Article
ID GAMMA-GLUTAMYL-TRANSFERASE; PROTEIN-ALDEHYDE ADDUCTS; NONALCOHOLIC
   STEATOHEPATITIS; ALANINE AMINOTRANSFERASE; OXIDATIVE STRESS; FATTY
   LIVER; METABOLIC SYNDROME; UNITED-STATES; DISEASE; SERUM
AB Background: Although both ethanol consumption and overweight alter the activities of hepatic enzymes in circulation, the differentiation of an alcohol or nonalcohol basis for such changes remains problematic. The magnitude of alterations occurring among moderate drinkers has remained obscure.
   Objective: We examined the links between moderate ethanol consumption, body mass index (BMI; in kg/m(2)), and liver enzymes.
   Design: Serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), and gamma-glutamyltransferase (GGT) were recorded from 2164 apparently healthy participants (1028 men, 1136 women) reporting either no alcohol (abstainers) or < 40 g ethanol consumption per day (moderate drinkers). The study population was further classified according to BMI as follows: < 19 (underweight), >= 19 and < 25 (normal weight), >= 25 and >= 30 (overweight), and >= 30 ( obese).
   Results: Serum ALT ( P < 0.05) and GGT ( P < 0.001) but not AST ( P = 0.805) activities in moderate drinkers were higher than those in abstainers. For all enzymes, a significant main effect was observed of increasing BMI, which was more striking in moderate drinkers than in abstainers. Tests of between- subjects effects indicated significant interactions with sex and drinking status, although not with sex and BMI.
   Conclusions: The effect of moderate alcohol consumption on liver enzymes increases with increasing BMI. These findings should be considered in the clinical assessment of overweight alcohol consumers and in the definition of normal ranges for liver enzymes. These results may also help to develop new approaches for examining patients with fatty liver induced by either ethanol or adiposity.
C1 [Alatalo, Paeivikki I.; Koivisto, Heidi M.; Hietala, Johanna P.; Puukka, Katri S.; Niemelae, Onni J.] Seinajoki Cent Hosp, Dept Lab Med, FIN-60220 Seinajoki, Finland.
   [Alatalo, Paeivikki I.; Koivisto, Heidi M.; Hietala, Johanna P.; Puukka, Katri S.; Niemelae, Onni J.] Seinajoki Cent Hosp, Med Res Unit, FIN-60220 Seinajoki, Finland.
   [Alatalo, Paeivikki I.; Koivisto, Heidi M.; Hietala, Johanna P.; Puukka, Katri S.; Niemelae, Onni J.] Univ Tampere, Seinajoki, Finland.
   [Bloigu, Risto] Univ Oulu, Med Informat Grp, Oulu, Finland.
C3 Seinajoki Central Hospital; Seinajoki Central Hospital; Tampere
   University; University of Oulu
RP Niemelä, OJ (corresponding author), Seinajoki Cent Hosp, Dept Lab Med, FIN-60220 Seinajoki, Finland.
EM onni.niemela@epshp.fi
RI Kangastupa, Päivikki/JZZ-0468-2024
OI Kangastupa, Paivikki/0000-0003-0695-6073
FU Finnish Foundation
FX Supported by a grant from the Finnish Foundation for Alcohol Studies (to
   OJN).
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NR 47
TC 102
Z9 110
U1 1
U2 7
PU AMER SOC CLINICAL NUTRITION
PI BETHESDA
PA 9650 ROCKVILLE PIKE, SUBSCRIPTIONS, RM L-3300, BETHESDA, MD 20814-3998
   USA
SN 0002-9165
J9 AM J CLIN NUTR
JI Am. J. Clin. Nutr.
PD OCT 1
PY 2008
VL 88
IS 4
BP 1097
EP 1103
DI 10.1093/ajcn/88.4.1097
PG 7
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 358FX
UT WOS:000259903600031
PM 18842799
OA Bronze
DA 2025-06-11
ER

PT J
AU Perségol, L
   Vergès, B
   Gambert, P
   Duvillard, L
AF Persegol, Laurence
   Verges, Bruno
   Gambert, Philippe
   Duvillard, Laurence
TI Inability of HDL from abdominally obese subjects to counteract the
   inhibitory effect of oxidized LDL on vasorelaxation
SO JOURNAL OF LIPID RESEARCH
LA English
DT Article
DE obesity; high density lipoprotein; oxidized low density lipoprotein;
   triglycerides; apolipoprotein A-I
ID HIGH-DENSITY-LIPOPROTEIN; ELEVATED OXIDATIVE STRESS; APOLIPOPROTEIN-A-I;
   INSULIN-RESISTANCE; ENDOTHELIAL FUNCTION; METABOLIC SYNDROME; ARTERIAL
   RELAXATION; CHOLESTEROL; DYSFUNCTION; ACTIVATION
AB Abdominal obesity is associated with a decreased plasma concentration of HDL cholesterol and with qualitative modifications of HDL, such as triglyceride enrichment. Our aim was to determine, in isolated aorta rings, whether HDL from obese subjects can counteract the inhibitory effect of oxidized low density lipoprotein ( OxLDL) on endothelium-dependent vasodilation as efficiently as HDL from normolipidemic, lean subjects. Plasma triglycerides were 74% higher (P < 0.005) in obese subjects compared with controls, and apolipoprotein A-I (apoA-I) and HDL cholesterol concentrations were 12% and 17% lower (P < 0.05), respectively. HDL from control subjects significantly reduced the inhibitory effect of OxLDL on vasodilation [maximal relaxation (E-max) = 82.1 +/- 8.6% vs. 54.1 +/- 8.1%; P < 0.0001], but HDL from obese subjects had no effect (E-max = 47.2 +/- 12.5% vs. 54.1 +/- 8.1%; NS). In HDL from abdominally obese subjects compared with HDL from controls, the apoA-I content was 12% lower (P < 0.05) and the triglyceride-to-cholesteryl ester ratio was 36% higher (P = 0.08)). E-max(OxLDL + HDL) was correlated with HDL apoA-I content and triglyceride-to-cholesteryl ester ratio (r = 0.36 and r = -0.38, respectively; P < 0.05). We conclude that in abdominally obese subjects, the ability of HDL to counteract the inhibitory effect of OxLDL on vascular relaxation is impaired. This could contribute to the increased cardiovascular risk observed in these subjects.
C1 INSERM, U866, F-21000 Dijon, France.
   Univ Burgundy, Inst Fed Rech 100, F-21000 Dijon, France.
   Ctr Hosp Univ Dijon Bocage Hosp, Dept Endocrinol & Metab Dis, F-21000 Dijon, France.
C3 Institut Agro; AgroSup Dijon; Institut National de la Sante et de la
   Recherche Medicale (Inserm); Universite Bourgogne Europe; Universite
   Bourgogne Europe; Universite Bourgogne Europe; CHU Dijon Bourgogne
RP Duvillard, L (corresponding author), INSERM, U866, F-21000 Dijon, France.
EM laurence.duvillard@chu-dijon.fr
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NR 34
TC 40
Z9 41
U1 0
U2 2
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0022-2275
EI 1539-7262
J9 J LIPID RES
JI J. Lipid Res.
PD JUN
PY 2007
VL 48
IS 6
BP 1396
EP 1401
DI 10.1194/jlr.M600309-JLR200
PG 6
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 170JH
UT WOS:000246659000017
PM 17329618
OA hybrid
DA 2025-06-11
ER

PT J
AU Ortega, E
   Koska, J
   Salbe, AD
   Tataranni, PA
   Bunt, JC
AF Ortega, E
   Koska, J
   Salbe, AD
   Tataranni, PA
   Bunt, JC
TI Serum γ-glutamyl transpeptidase is a determinant of insulin resistance
   independently of adiposity in Pima Indian children
SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Article
ID NONALCOHOLIC FATTY LIVER; ARTERY RISK DEVELOPMENT; YOUNG-ADULTS CARDIA;
   METABOLIC SYNDROME; OXIDATIVE STRESS; TRANSFERASE; DISEASE; SENSITIVITY;
   AMINOTRANSFERASE; ADOLESCENTS
AB Context: Elevated activities of serum enzymes, including alanine aminotransferase (ALT), aspartate aminotransferase (AST), and gamma-glutamyltransferase (GGT), have been associated with obesity and insulin resistance (IR). ALT is an independent predictor of type 2 diabetes mellitus (T2DM) in adult Pima Indians, and GGT predicts T2DM in other adult populations.
   Objective: Our aim was to establish whether independent relationships exist between either adiposity or IR and hepatic enzymes in a group of Pima Indian children.
   Subjects and Methods: In a cross-sectional study, 44 children ( 22 males and 22 females; 7 - 11 yr old) were measured for weight (WT), height, percent body fat, and serum activities of ALT, AST, and GGT. Body mass index ( kilograms per meter squared) was calculated. IR was calculated from fasting plasma concentrations of glucose and insulin using the homeostasis model assessment (HOMA-IR).
   Results: Hepatic enzymes were positively associated with obesity measures, fasting insulin, and HOMA-IR. GGT was additionally associated with serum lipids and white blood cell count. GGT, but not AST or ALT, was a significant determinant of HOMA-IR independently of age, sex, and WT, body mass index, or percent body fat. The model that accounted for the largest portion of the variance in HOMA-IR included WT (beta = 0.004; P = 0.008) and GGT (beta = 0.20; P = 0.004; total R-2 = 0.62; P < 0.0001).
   Conclusion: Significant relationships between adiposity and hepatic enzyme activities exist during childhood in Pima Indians. Whether serum GGT activity predicts the development of T2DM in these children remains to be determined in follow-up studies.
C1 NIDDKD, Obes & Diabet Clin Res Sect, NIH, Phoenix, AZ 85016 USA.
C3 National Institutes of Health (NIH) - USA; NIH National Institute of
   Diabetes & Digestive & Kidney Diseases (NIDDK)
RP NIDDKD, Obes & Diabet Clin Res Sect, NIH, 4212 N 16th St,Room 533, Phoenix, AZ 85016 USA.
EM emilioo@mail.nih.gov
RI Ortega Martínez de V, Emilio/AAB-2072-2022; Koska, Juraj/JYQ-9753-2024
OI Ortega Martinez de Victoria, Emilio/0000-0002-2217-8905
FU Intramural NIH HHS Funding Source: Medline
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NR 29
TC 46
Z9 52
U1 0
U2 6
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0021-972X
EI 1945-7197
J9 J CLIN ENDOCR METAB
JI J. Clin. Endocrinol. Metab.
PD APR
PY 2006
VL 91
IS 4
BP 1419
EP 1422
DI 10.1210/jc.2005-1783
PG 4
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 029YW
UT WOS:000236601300038
PM 16434459
OA Bronze
DA 2025-06-11
ER

PT J
AU Bugianesi, E
   Gastaldelli, A
   Vanni, E
   Gambino, R
   Cassader, M
   Baldi, S
   Ponti, V
   Pagano, G
   Ferrannini, E
   Rizzetto, M
AF Bugianesi, E
   Gastaldelli, A
   Vanni, E
   Gambino, R
   Cassader, M
   Baldi, S
   Ponti, V
   Pagano, G
   Ferrannini, E
   Rizzetto, M
TI Insulin resistance in non-diabetic patients with non-alcoholic fatty
   liver disease: sites and mechanisms
SO DIABETOLOGIA
LA English
DT Article
DE fatty liver; glucose disposal; glucose production; glycerol appearance;
   lipoperoxidation
ID ENDOGENOUS GLUCOSE-PRODUCTION; DEPENDENT DIABETES-MELLITUS;
   ACID-METABOLISM; CRYPTOGENIC CIRRHOSIS; OXIDATIVE STRESS;
   GENE-EXPRESSION; NATURAL-HISTORY; STEATOHEPATITIS; OBESITY; ASSOCIATION
AB Aims/Hypothesis: Non-alcoholic fatty liver disease (NAFLD) has been associated with the metabolic syndrome. However, it is not clear whether insulin resistance is an independent feature of NAFLD, and it remains to be determined which of the in vivo actions of insulin are impaired in this condition. Methods: We performed a twostep (1.5 and 6 pmol min(-1) kg(-1)) euglycaemic insulin clamp coupled with tracer infusion ([6,6-H-2(2)] glucose and [H-2(5)] glycerol) and indirect calorimetry in 12 non-obese, normolipidaemic, normotensive, non-diabetic patients with biopsy-proven NAFLD and six control subjects. Results: In NAFLD patients, endogenous glucose production ( basal and during the clamp) was normal; however, peripheral glucose disposal was markedly decreased ( by 30% and 45% at the low and high insulin doses, respectively, p< 0.0001) at higher plasma insulin levels (p = 0.05), due to impaired glucose oxidation (p = 0.003) and glycogen synthesis ( p< 0.001). Compared with control subjects, glycerol appearance and lipid oxidation were significantly increased in NAFLD patients in the basal state, and were suppressed by insulin to a lesser extent ( p< 0.05 - 0.001). The lag phase of the in vitro copper-catalysed peroxidation of LDL particles was significantly shorter in the patients than in the control subjects ( 48 +/- 12 vs 63 +/- 13 min, p< 0.04). Lipid oxidation was significantly related to endogenous glucose production, glucose disposal, the degree of hepatic steatosis, and LDL oxidisability. Conclusions/interpretation: Insulin resistance appears to be an intrinsic defect in NAFLD, with the metabolic pattern observed indicating that adipose tissue is an important site.
C1 Univ Turin, Azienda Osped San Giovanni Battista, UOADU Gastroepatol, I-10126 Turin, Italy.
   Univ Turin, San Giovanni Battista Hosp, Div Gastrohepatol, Turin, Italy.
   CNR, Inst Clin Physiol, Metab Unit, I-56100 Pisa, Italy.
   Univ Pisa, Dept Internal Med, Pisa, Italy.
   Univ Turin, San Giovanni Battista Hosp, Dept Internal Med, Turin, Italy.
C3 A.O.U. Citta della Salute e della Scienza di Torino; AOU San Giovanni
   Battista-Molinette; University of Turin; University of Turin; A.O.U.
   Citta della Salute e della Scienza di Torino; AOU San Giovanni
   Battista-Molinette; Consiglio Nazionale delle Ricerche (CNR); Istituto
   di Fisiologia Clinica (IFC-CNR); University of Pisa; A.O.U. Citta della
   Salute e della Scienza di Torino; AOU San Giovanni Battista-Molinette;
   University of Turin
RP Univ Turin, Azienda Osped San Giovanni Battista, UOADU Gastroepatol, Corso Bramante 88, I-10126 Turin, Italy.
EM ebugianesi@yahoo.it
RI Ferrannini, Ele/B-8198-2013; GAMBINO, Roberto/AAC-7517-2022;
   Gastaldelli, Amalia/H-3319-2014
OI Gastaldelli, Amalia/0000-0003-2594-1651
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NR 59
TC 588
Z9 662
U1 3
U2 27
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0012-186X
EI 1432-0428
J9 DIABETOLOGIA
JI Diabetologia
PD APR
PY 2005
VL 48
IS 4
BP 634
EP 642
DI 10.1007/s00125-005-1682-x
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 918CI
UT WOS:000228515900007
PM 15747110
OA Bronze
DA 2025-06-11
ER

PT J
AU Amini, MR
   Majd, SS
   Salavatizadeh, M
   Djafari, F
   Askari, G
   Hekmatdoost, A
AF Amini, Mohammad Reza
   Majd, Sara Sadeghi
   Salavatizadeh, Marieh
   Djafari, Farhang
   Askari, Gholamreza
   Hekmatdoost, Azita
TI The effects of policosanol supplementation on creatinine: a systematic
   review and dose-response meta-analysis of randomized controlled trials
SO BMC COMPLEMENTARY MEDICINE AND THERAPIES
LA English
DT Review
DE Policosanol; Creatinine; Randomized controlled trials; Meta-analysis
ID II HYPERCHOLESTEROLEMIA; OXIDATIVE STRESS; RENAL-FUNCTION; DOUBLE-BLIND;
   METABOLIC SYNDROME; CHOLESTEROL LEVELS; SERUM CREATININE;
   ELDERLY-PATIENTS; GENE-EXPRESSION; RISK-FACTOR
AB ObjectivePolicosanol, a compound generated from sugar cane, consists of alcohols such as octacosanol, hexacosanol, and triacontanol, which possess antioxidant properties. Evaluating the impact of this antioxidant on serum creatinine in clinical settings is essential because of the contradictory findings. This comprehensive review and dose-response meta-analysis attempts to evaluate the impact of policosanol supplementation on creatinine levels.MethodsA comprehensive search was performed in bibliographic databases such as Cochrane, PubMed, Google Scholar, Scopus, and Web of Science, covering the period from inception to November 2023. The necessary data was retrieved, and pertinent randomized controlled trials (RCTs) that satisfied the inclusion criteria were included. Weighted mean differences (WMDs) were the reported measure of the pooled effects. To find between-study heterogeneities, the I-squared test was employed.ResultsA total of 2427 participants were involved in the twenty-one RCTs that were included. A meta-analysis showed that policosanol had no significant change in creatinine levels in participants consuming policosanol compared to placebo consumers (WMD = 0.21 mu mol/l; 95% CI = - 0.85 to 1.26; P = 0.70). Policosanol consumption for durations >= 24 weeks significantly decreased creatinine, according to subgroup studies. There was a non-linear correlation between changes in creatinine levels and the dosage of prescription policosanol (P non_linearity = 0.002). However, the treatment time did not have a significant impact on creatinine levels in a non-linear manner (P non_linearity = 0.24).ConclusionPolicosanol supplementation has no significant effect on creatinine levels.
C1 [Amini, Mohammad Reza] Shahid Beheshti Univ Med Sci, Student Res Comm, Fac Nutr & Food Technol, Dept Clin Nutr & Dietet, Tehran, Iran.
   [Amini, Mohammad Reza; Askari, Gholamreza] Isfahan Univ Med Sci, Nutr & Food Secur Res Ctr, Isfahan, South Korea.
   [Amini, Mohammad Reza; Askari, Gholamreza] Isfahan Univ Med Sci, Sch Nutr & Food Sci, Dept Community Nutr, Isfahan, South Korea.
   [Majd, Sara Sadeghi] Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Clin Nutr, Tehran, Iran.
   [Salavatizadeh, Marieh; Hekmatdoost, Azita] Shahid Beheshti Univ Med Sci, Dept Clin Nutr & Dietet, Natl Nutr & Food Technol Res Inst, Tehran, Iran.
   [Djafari, Farhang] Cent Queensland Univ, Sch Hlth Med & Appl Sci, Brisbane, Australia.
   [Hekmatdoost, Azita] Shahid Beheshti Univ Med Sci, Fac Nutr Sci & Food Technol, Dept Clin Nutr, Tehran, Iran.
C3 Shahid Beheshti University Medical Sciences; Tehran University of
   Medical Sciences; Shahid Beheshti University Medical Sciences; Central
   Queensland University; Shahid Beheshti University Medical Sciences
RP Hekmatdoost, A (corresponding author), Shahid Beheshti Univ Med Sci, Dept Clin Nutr & Dietet, Natl Nutr & Food Technol Res Inst, Tehran, Iran.; Hekmatdoost, A (corresponding author), Shahid Beheshti Univ Med Sci, Fac Nutr Sci & Food Technol, Dept Clin Nutr, Tehran, Iran.
EM A_hekmat2000@yahoo.com
RI Amini, Mohammad/ABD-9638-2020
FU Student Research Committee, Shahid Beheshti University of Medical
   Sciences, Tehran, Iran.
FX Not applicable.
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NR 78
TC 0
Z9 0
U1 0
U2 0
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 2662-7671
J9 BMC COMPLEMENT MED
JI BMC Complement. Med. Ther.
PD MAY 17
PY 2025
VL 25
IS 1
AR 182
DI 10.1186/s12906-025-04911-0
PG 16
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA 2SB7I
UT WOS:001489964500002
PM 40382621
DA 2025-06-11
ER

PT J
AU Sepehrinia, M
   Khanmohammadi, S
   Rezaei, N
   Kuchay, MS
AF Sepehrinia, Matin
   Khanmohammadi, Shaghayegh
   Rezaei, Nima
   Kuchay, Mohammad Shafi
TI Dietary inflammatory potential and metabolic (dysfunction)-associated
   steatotic liver disease and its complications: A comprehensive review
SO CLINICAL NUTRITION ESPEN
LA English
DT Review
DE Metabolic (dysfunction)-associated steatotic; liver disease; Dietary
   inflammatory index; Diet; Hepatocellular carcinoma; Non-alcoholic fatty
   liver disease
ID C-REACTIVE PROTEIN; NONINVASIVE DIAGNOSIS; MEDITERRANEAN DIET; INDEX;
   ASSOCIATION; RISK; PATHOGENESIS; PREVALENCE; MECHANISMS; ADHERENCE
AB Metabolic (dysfunction)-associated steatotic liver disease (MASLD) represents a spectrum of liver pathologies linked to metabolic syndrome components. Inflammation emerges as a pivotal player in MASLD pathogenesis, initiating and perpetuating hepatic injury. Diet, a modifiable risk factor, influences inflammation levels and MASLD progression. This review synthesizes existing evidence on the association between pro-inflammatory diets, assessed via the Dietary Inflammatory Index (DII) and Empirical Dietary Inflammatory Potential (EDIP), and MASLD. Evidence suggests a significant association between higher DII/EDIP scores and MASLD risk, with studies revealing a positive correlation between inflammatory diet intake and MASLD occurrence, particularly in males. However, inconsistencies exist regarding the influence of body mass index (BMI) on this association and criticisms regarding adjustment for BMI and reliance on surrogate markers necessitate cautious interpretation. Limited data suggest a potential link between dietary inflammatory potential and advanced liver fibrosis and heightened risk of hepatocellular carcinoma (HCC) with increased DII/EDIP scores, albeit requiring further confirmation through gold-standard assessment methods. Dietary-induced inflammation exacerbates MASLD pathogenesis through multiple pathways, including insulin resistance, adipose tissue dysfunction, gut microbiota alterations, and oxidative stress, culminating in hepatic steatosis, inflammation, and fibrosis. Further research utilizing robust methodologies is imperative to confirm these findings and elucidate underlying mechanisms, thus informing targeted dietary interventions for MASLD management. (c) 2024 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.
C1 [Sepehrinia, Matin] Shahid Beheshti Univ Med Sci, Natl Nutr & Food Technol Res Inst, Fac Nutr Sci & Food Technol, WHO Collaborating Ctr, Tehran, Iran.
   [Sepehrinia, Matin] Fasa Univ Med Sci, Student Res Comm, Fasa, Iran.
   [Khanmohammadi, Shaghayegh] Endocrinol & Metab Populat Sci Inst, Noncommunicable Dis Res Ctr, Tehran, Iran.
   [Khanmohammadi, Shaghayegh] Univ Med Sci, Tehran, Iran.
   [Khanmohammadi, Shaghayegh] Univ Tehran Med Sci, Sch Med, Tehran, Iran.
   [Rezaei, Nima] Univ Tehran Med Sci, Sch Med, Dept Immunol, Tehran, Iran.
   [Kuchay, Mohammad Shafi] Medanta Medicity, Div Endocrinol & Diabet, Gurugram 122001, Haryana, India.
C3 Shahid Beheshti University Medical Sciences; World Health Organization;
   Tehran University of Medical Sciences; Tehran University of Medical
   Sciences; Tehran University of Medical Sciences
RP Kuchay, MS (corresponding author), Medanta Medicity, Div Endocrinol & Diabet, Gurugram 122001, Haryana, India.
EM Matinsepehrinia98@gmail.com; shaghayegh.khanmohammadi@gmail.com;
   rezaei_nima@tums.ac.ir; khanmohammadi@gmail.com
RI Kuchay, M/IZQ-0398-2023; Sepehrinia, Matin/KQU-1834-2024; Kuchay,
   Mohammad Shafi/L-6152-2017; Rezaei, Nima/B-4245-2008; Khanmohammadi,
   Shaghayegh/GLT-9527-2022
OI Sepehrinia, Matin/0009-0006-6063-0030; Kuchay, Mohammad
   Shafi/0000-0003-3933-6137; Rezaei, Nima/0000-0002-3836-1827;
   Khanmohammadi, Shaghayegh/0000-0002-8732-0191
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NR 91
TC 5
Z9 5
U1 5
U2 5
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2405-4577
J9 CLIN NUTR ESPEN
JI Clin. Nutr. ESPEN
PD FEB
PY 2025
VL 65
BP 162
EP 171
DI 10.1016/j.clnesp.2024.11.032
EA DEC 2024
PG 10
WC Nutrition & Dietetics
WE Emerging Sources Citation Index (ESCI)
SC Nutrition & Dietetics
GA P1G8R
UT WOS:001375491100001
PM 39608495
DA 2025-06-11
ER

PT J
AU Bai, MR
   Abirami, K
   Gayathri, R
   Vedantham, S
   Shobana, S
   Nagarajan, LP
   Gunasekaran, G
   Nagamuthu, G
   Malini, HM
   Gokulakrishnan, K
   Sandhya, N
   Jeevan, RG
   Anjana, RM
   Unnikrishnan, R
   Krishnaswamy, K
   Sudha, V
   Mohan, V
AF Bai, Mookambika Ramya
   Abirami, Kuzhandaivelu
   Gayathri, Rajagopal
   Vedantham, Srinivasan
   Shobana, Shanmugam
   Nagarajan, Lakshmi Priya
   Gunasekaran, Geetha
   Nagamuthu, Gayathri
   Malini, Hudgekar Madhav
   Gokulakrishnan, Kuppan
   Sandhya, Narasimhan
   Jeevan, Ramajeevan Ganesh
   Anjana, Ranjit Mohan
   Unnikrishnan, Ranjit
   Krishnaswamy, Kamala
   Sudha, Vasudevan
   Mohan, Viswanathan
TI Effect of low vs high dietary-advanced glycation end products on
   insulin-sensitivity and inflammatory- markers among overweight/obese
   Asian-Indian adults-A randomised controlled trial
SO INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION
LA English
DT Article
DE Low and high dAGE; Indian diets; oral disposition index; serum-AGE;
   obesity; South asians
ID URBAN-RURAL EPIDEMIOLOGY; OXIDATIVE STRESS; METABOLIC SYNDROME;
   ENDOTHELIAL FUNCTION; RISK-FACTORS; RESISTANCE; OBESITY; GLUCOSE;
   METHODOLOGY; ENDPRODUCTS
AB The present study investigated the effect of low vs high-dietary-Advanced Glycation End products-based diets on oral disposition index-(DIo)-a marker of islet beta-cell function and cardiometabolic risks factors in 38-overweight and obese Asian Indian-adults (aged 25-45 years with body-mass-index (BMI) >= 23kg/m(2)) through 12-week isocaloric crossover feeding trial. Biochemical-measures included-glucose tolerance test (GTT), Insulin assay (0,30 and 120 min), lipid-profile, serum-adiponectin, serum-AGE and serum-Thiobarbituric acid reactive substances-(TBARS) assessed both at baseline and end of each intervention. Generalised linear models showed that low-dAGE diet significantly improved in oral disposition index [Least Square Mean (SE), +0.3 (0.1); p = 0.03] compared to high-dAGE diet. The low-dAGE diet also showed a significant reduction in 30-minutes plasmapost-glucose-challenge-value:(-8.1[3.8] (mg/dl) vs 3.8 [3.8] (mg/dl); p = 0.01), serum-AGEs-(-3.2 [0.2] (mu g/ml) vs -0.8 [0.2] (mu g/ml); p = <0.0001) compared to high-dAGE diet. In summary, low-dAGE diets exhibited improvement in the insulin-sensitivity and reduction in the inflammatory levels compared to high-dAGE diets. Hence, study first time in India revealed that low dAGE diets could be a potential strategy to reduce diabetes risk.
C1 [Bai, Mookambika Ramya; Abirami, Kuzhandaivelu; Gayathri, Rajagopal; Shobana, Shanmugam; Nagarajan, Lakshmi Priya; Gunasekaran, Geetha; Nagamuthu, Gayathri; Malini, Hudgekar Madhav; Jeevan, Ramajeevan Ganesh; Krishnaswamy, Kamala; Sudha, Vasudevan] Madras Diabet Res Fdn, Dept Foods Nutr & Dietet Res, Chennai, India.
   [Bai, Mookambika Ramya] Sastra Univ, Dept Biotechnol, Thanjavur, India.
   [Vedantham, Srinivasan] DifGen Pharmaceut LLC, Miramar, FL USA.
   [Shobana, Shanmugam] Madras Diabet Res Fdn, Dept Diabet Food Technol, Chennai, India.
   [Gokulakrishnan, Kuppan; Sandhya, Narasimhan] Natl Inst Mental Hlth & Neuro Sci NIMHANS, Dept Neurochem, Bengaluru, India.
   [Anjana, Ranjit Mohan; Unnikrishnan, Ranjit; Mohan, Viswanathan] Madras Diabet Res Fdn, ICMR Ctr Adv Res Diabet, Dr Mohans Diabet Specialties Ctr, IDF Ctr Excellence Diabet,Dept Diabetol, Chennai, India.
C3 Madras Diabetes Research Foundation; Shanmugha Arts, Science, Technology
   & Research Academy (SASTRA); Madras Diabetes Research Foundation;
   National Institute of Mental Health & Neurosciences - India; Madras
   Diabetes Research Foundation; Indian Council of Medical Research (ICMR)
RP Mohan, V (corresponding author), Madras Diabet Res Fdn, ICMR Ctr Adv Res Diabet, Chennai 600086, India.; Mohan, V (corresponding author), Dr Mohans Diabet Special Ctr, IDF Ctr Excellence Diabet Care, Chennai 600086, India.
EM drmohans@diabetes.ind.in
RI Viswanathan, Mohan/C-2321-2009
FU Department of Biotechnology, Ministry of Science & Technology, New
   Delhi, India
FX The study was funded by the Department of Biotechnology, Ministry of
   Science & Technology, New Delhi, India
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NR 43
TC 0
Z9 0
U1 1
U2 2
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0963-7486
EI 1465-3478
J9 INT J FOOD SCI NUTR
JI Int. J. Food Sci. Nutr.
PD NOV 16
PY 2024
VL 75
IS 8
BP 835
EP 845
DI 10.1080/09637486.2024.2405121
EA OCT 2024
PG 11
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA N2O6E
UT WOS:001328509300001
PM 39360559
DA 2025-06-11
ER

PT J
AU Macasek, J
   Stankova, B
   Zak, A
   Ruzicková, M
   Bruha, R
   Kutová, S
   Vecka, M
   Zeman, M
AF Macasek, Jaroslav
   Stankova, Barbora
   Zak, Ales
   Ruzickova, Marketa
   Bruha, Radan
   Kutova, Simona
   Vecka, Marek
   Zeman, Miroslav
TI Associations of plasma phospholipid cis-vaccenic acid with insulin
   resistance markers in non-diabetic men with hyperlipidemia
SO NUTRITION & DIABETES
LA English
DT Article
ID METABOLIC SYNDROME; FATTY-ACIDS; PALMITOLEIC ACID; DESATURASE ACTIVITY;
   OXIDATIVE STRESS; RISK; ADULTS; LIVER; PATHOGENESIS; SENSITIVITY
AB Background: The role of fatty acids (FA) in the pathogenesis of insulin resistance and hyperlipidemia is a subject of intensive research. Several recent works have suggested cis-vaccenic acid (cVA) in plasma lipid compartments, especially in plasma phospholipids (PL) or erythrocyte membranes, could be associated with markers of insulin sensitivity and cardiovascular health. Nevertheless, not all the results of research work testify to these beneficial effects of cVA. Therefore, we decided to investigate the relations of proportion of cVA in plasma PL to markers of insulin resistance in hyperlipidemic men. Subjects: In 231 men (median age 50) with newly diagnosed hyperlipidemia, we analyzed basic clinical parameters together with FA composition of plasma PL and stratified them according to the content of cVA into upper quartile (Q4) and lower quartile (Q1) groups. We examined also small control group of 50 healthy men. Results: The individuals in Q4 differed from Q1 by lower plasma insulin (p < 0.05), HOMA-IR values (p < 0.01), and apolipoprotein B concentrations (p < 0.001), but by the higher total level of nonesterified FA (p < 0.01). Both groups had similar age, anthropometrical, and other lipid parameters. In plasma PL, the Q4 group had lower content of the sum of n-6 polyunsaturated FA, due to decrease of gamma-linolenic and dihomo-gamma-linolenic acids, whereas the content of monounsaturated FA (mainly oleic and palmitoleic) was in Q4 higher. Conclusions: Our results support hypothesis that plasma PL cVA could be associated with insulin sensitivity in men with hyperlipidemia.
C1 [Macasek, Jaroslav; Stankova, Barbora; Zak, Ales; Ruzickova, Marketa; Bruha, Radan; Kutova, Simona; Vecka, Marek; Zeman, Miroslav] Charles Univ Prague, Fac Med 1, Dept Internal Med 4, U Nemocnice 2, Prague 12808, Czech Republic.
   [Macasek, Jaroslav; Stankova, Barbora; Zak, Ales; Ruzickova, Marketa; Bruha, Radan; Kutova, Simona; Vecka, Marek; Zeman, Miroslav] Gen Univ Hosp Prague, U Nemocnice 2, Prague 12808, Czech Republic.
   [Stankova, Barbora; Vecka, Marek] Charles Univ Prague, Inst Clin Chem & Lab Diagnost, Fac Med 1, Na Bojisti 3, Prague 12108, Czech Republic.
C3 Charles University Prague; General University Hospital Prague; Charles
   University Prague
RP Vecka, M (corresponding author), Charles Univ Prague, Fac Med 1, Dept Internal Med 4, U Nemocnice 2, Prague 12808, Czech Republic.; Vecka, M (corresponding author), Gen Univ Hosp Prague, U Nemocnice 2, Prague 12808, Czech Republic.; Vecka, M (corresponding author), Charles Univ Prague, Inst Clin Chem & Lab Diagnost, Fac Med 1, Na Bojisti 3, Prague 12108, Czech Republic.
EM marek.vecka@lf1.cuni.cz
RI Macasek, Jaroslav/G-8337-2016; Bruha, Radan/A-4432-2008; Vecka,
   Marek/AAB-9358-2022; Zak, Ales/G-8318-2016; Stankova,
   Barbora/L-7933-2016
FU Ministry of Health of the Czech Republic [MH CZ DRO-VFN64165,
   NU23-01-00288]; Ministry of Education, Youth and Sports of the Czech
   Republic; Charles University Research program,
   Cooperatio-Gastroenterology
FX This research was funded by the Ministry of Health of the Czech
   Republic, grants number MH CZ DRO-VFN64165 and NU23-01-00288, and the
   Ministry of Education, Youth and Sports of the Czech Republic, grant the
   Charles University Research program, Cooperatio-Gastroenterology, The
   statistical help of Barbora Pejchalova is greatly acknowledged.
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NR 58
TC 1
Z9 1
U1 6
U2 9
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 2044-4052
J9 NUTR DIABETES
JI Nutr. Diabetes
PD SEP 11
PY 2024
VL 14
IS 1
AR 73
DI 10.1038/s41387-024-00332-z
PG 8
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA F6T7V
UT WOS:001311129300002
PM 39261487
OA gold
DA 2025-06-11
ER

PT J
AU Tao, YY
   Zhao, QL
   Lu, CB
   Yong, WL
   Xu, MY
   Wang, Z
   Leng, XP
AF Tao, Yangyang
   Zhao, Qinglong
   Lu, Chengbo
   Yong, Weilin
   Xu, Mingyuan
   Wang, Zhuo
   Leng, Xiaoping
TI Melatonin suppresses atherosclerosis by ferroptosis inhibition via
   activating NRF2 pathway
SO FASEB JOURNAL
LA English
DT Article
DE antioxidant; atherosclerosis; ferroptosis; lipoprotein-associated
   phospholipase A2 (Lp-PLA2); melatonin (MLT)
ID CARDIOVASCULAR MORTALITY; PHOSPHOLIPASE A(2); METABOLIC SYNDROME;
   RISK-FACTORS; CELL-DEATH; APOPTOSIS; DISEASES; EVENTS
AB Melatonin (MLT), a conserved small indole compound, exhibits anti-inflammatory and antioxidant properties, contributing to its cardioprotective effects. Lipoprotein-associated phospholipase A2 (Lp-PLA2) is associated with atherosclerosis disease risk, and is known as an atherosclerosis risk biomarker. This study aimed to investigate the impact of MLT on Lp-PLA2 expression in the atherosclerotic process and explore the underlying mechanisms involved. In vivo, ApoE(-/-) mice were fed a high-fat diet, with or without MLT administration, after which the plaque area and collagen content were assessed. Macrophages were pretreated with MLT combined with ox-LDL, and the levels of ferroptosis-related proteins, NRF2 activation, mitochondrial function, and oxidative stress were measured. MLT administration significantly attenuated atherosclerotic plaque progression, as evidenced by decreased plaque area and increased collagen. Compared with those in the high-fat diet (HD) group, the levels of glutathione peroxidase 4 (GPX4) and SLC7A11 (xCT, a cystine/glutamate transporter) in atherosclerotic root macrophages were significantly increased in the MLT group. In vitro, MLT activated the nuclear factor-E2-related Factor 2 (NRF2)/SLC7A11/GPX4 signaling pathway, enhancing antioxidant capacity while reducing lipid peroxidation and suppressing Lp-PLA2 expression in macrophages. Moreover, MLT reversed ox-LDL-induced ferroptosis, through the use of ferrostatin-1 (a ferroptosis inhibitor) and/or erastin (a ferroptosis activator). Furthermore, the protective effects of MLT on Lp-PLA2 expression, antioxidant capacity, lipid peroxidation, and ferroptosis were decreased in ML385 (a specific NRF2 inhibitor)-treated macrophages and in AAV-sh-NRF2 treated ApoE(-/-) mice. MLT suppresses Lp-PLA2 expression and atherosclerosis processes by inhibiting macrophage ferroptosis and partially activating the NRF2 pathway.
C1 [Tao, Yangyang; Xu, Mingyuan; Wang, Zhuo; Leng, Xiaoping] Harbin Med Univ, Dept Ultrasound, Affiliated Hosp 2, Xuefu Rd 246, Harbin 150086, Heilongjiang, Peoples R China.
   [Zhao, Qinglong] Harbin Med Univ, Dept Intervent Radiol, Affiliated Hosp 2, Harbin, Peoples R China.
   [Lu, Chengbo] Jiamusi Univ, Dept Cardiol, Affiliated Hosp 1, Jiamusi, Peoples R China.
   [Yong, Weilin] Harbin Med Univ, Dept Med Serv, Affiliated Hosp 2, Harbin, Peoples R China.
C3 Harbin Medical University; Harbin Medical University; Jiamusi
   University; Harbin Medical University
RP Leng, XP (corresponding author), Harbin Med Univ, Dept Ultrasound, Affiliated Hosp 2, Xuefu Rd 246, Harbin 150086, Heilongjiang, Peoples R China.
EM xpleng@ems.hrbmu.edu.cn
RI xu, mingyuan/HLG-5292-2023; Xu, Mingyuan/AAK-7151-2021
OI Tao, Yangyang/0009-0006-0479-3089; Xu, Mingyuan/0000-0002-1399-867X;
   Wang, Zhuo/0009-0004-5320-1217; leng, xiaoping/0000-0001-8883-8884
FU Key Support Program of the Regional Innovation and Development Joint
   Project of the National Natural Science Foundation of China; Experiment
   Center of the Second Affiliated Hospital of Harbin Medical University
FX We thanks to the Experiment Center of the Second Affiliated Hospital of
   Harbin Medical University. We would like to thank Quan Lin and Sainan
   Pang for cartoon illustration and experimental assistance.
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TC 8
Z9 8
U1 6
U2 19
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0892-6638
EI 1530-6860
J9 FASEB J
JI Faseb J.
PD MAY 31
PY 2024
VL 38
IS 10
AR e23678
DI 10.1096/fj.202400427RR
PG 18
WC Biochemistry & Molecular Biology; Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA RT1Y1
UT WOS:001229831600001
PM 38780199
DA 2025-06-11
ER

PT J
AU Pasdar, Y
   Moradi, F
   Cheshmeh, S
   Sedighi, M
   Saber, A
   Moradi, S
   Bonyani, M
   Najafi, F
AF Pasdar, Yahya
   Moradi, Fardin
   Cheshmeh, Sahar
   Sedighi, Mohammad
   Saber, Amir
   Moradi, Shima
   Bonyani, Mitra
   Najafi, Farid
TI Major dietary patterns and dietary inflammatory index in relation to
   dyslipidemia using cross-sectional results from the RaNCD cohort study
SO SCIENTIFIC REPORTS
LA English
DT Article
ID CORONARY-HEART-DISEASE; METABOLIC SYNDROME; LIPID PROFILES; FATTY-ACIDS;
   MEDITERRANEAN DIET; OXIDATIVE STRESS; RISK-FACTOR; DASH DIET;
   ASSOCIATION; CONSUMPTION
AB Dyslipidemia can increase the risk of heart attack and stroke due to the restriction of blood flow through the blood vessels. Dietary modification is an appropriate approach to reducing this phenomenon. This cross-sectional study aimed to evaluate major dietary patterns and the dietary inflammatory index (DII) in relation to dyslipidemia. 5954 participants in the Ravansar non-communicable diseases (RaNCD) cohort study were eligible for this study. Dyslipidemia was diagnosed based on the lipid profile under consideration of the RaNCD physician. Dietary patterns were assessed by principal component analysis. The three identified dietary patterns included (1) plant-based pattern; (2) high protein and sugar pattern; and (3) energy-dense dense pattern. DII was also calculated based on the dietary information from a validated semi-quantitative food frequency questionnaire (FFQ). We found that higher adherence to DII was significantly associated with increased odds of dyslipidemia after adjusting for age, sex, and physical activity (OR: 1.24; CI 95% 1.09-1.42). Additionally, higher adherence to the high protein and sugar diet and an energy-dense diet was significantly associated with higher odds for dyslipidemia (OR: 1.31; CI 95% 1.16-1.49) and (OR: 1.28; CI 95% 1.12-1.46). Nevertheless, according to our results, following plant-based diet had no association with dyslipidemia in both crude and adjusted models. Our findings revealed that greater adherence to DII, a high-protein, high-sugar diet, and an energy-dense diet can have undesirable effects on dyslipidemia.
C1 [Pasdar, Yahya; Saber, Amir] Kermanshah Univ Med Sci, Hlth Inst, Res Ctr Environm Determinants Hlth RCEDH, Dept Nutr Sci, Kermanshah, Iran.
   [Moradi, Fardin; Sedighi, Mohammad; Moradi, Shima] Kermanshah Univ Med Sci, Student Res Comm, Sch Nutr Sci & Food Technol, Kermanshah, Iran.
   [Cheshmeh, Sahar] Univ Potsdam, Mol & Expt Nutr Med Dept, Nuthetal, Germany.
   [Bonyani, Mitra] Kermanshah Univ Med Sci, Med Educ Dev Ctr, Kermanshah, Iran.
   [Najafi, Farid] Kermanshah Univ Med Sci, Res Ctr Environm Determinants Hlth RCEDH, Kermanshah, Iran.
C3 Kermanshah University of Medical Sciences; Kermanshah University of
   Medical Sciences; University of Potsdam; Kermanshah University of
   Medical Sciences; Kermanshah University of Medical Sciences
RP Moradi, S (corresponding author), Kermanshah Univ Med Sci, Student Res Comm, Sch Nutr Sci & Food Technol, Kermanshah, Iran.
EM Shima.moradi@kums.ac.ir
RI Moradi, Shima/Q-7455-2017; Najafi, Farid/JSL-1581-2023; Saber,
   Amir/AAQ-1618-2020; Pasdar, Yahya/J-9064-2017
FU RaNCD is part of the PERSIAN national cohort and we would like to thank
   Professor Reza Malekzadeh, Deputy of Research and Technology at the
   Ministry of Health and Medical Education of Iran and Director of the
   PERSIAN cohort, and also Dr. Hossein Poustchi,; Deputy of Research and
   Technology at the Ministry of Health and Medical Education of Iran
FX RaNCD is part of the PERSIAN national cohort and we would like to thank
   Professor Reza Malekzadeh, Deputy of Research and Technology at the
   Ministry of Health and Medical Education of Iran and Director of the
   PERSIAN cohort, and also Dr. Hossein Poustchi, Executive Director of
   PERSIAN cohort, for all their support during the design and running of
   RaNCD.
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NR 54
TC 2
Z9 3
U1 5
U2 6
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD NOV 4
PY 2023
VL 13
IS 1
AR 19075
DI 10.1038/s41598-023-46447-8
PG 10
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA X6QB2
UT WOS:001099663700060
PM 37925569
OA Green Submitted, gold, Green Published
DA 2025-06-11
ER

PT J
AU Putra, IGNE
   Daly, M
   Sutin, A
   Steptoe, A
   Robinson, E
AF Putra, I. Gusti Ngurah Edi
   Daly, Michael
   Sutin, Angelina
   Steptoe, Andrew
   Robinson, Eric
TI Psychological Pathways Explaining the Prospective Association Between
   Obesity and Physiological Dysregulation
SO HEALTH PSYCHOLOGY
LA English
DT Article
DE obesity; psychological well-being; weight discrimination; physiological
   health; biomarkers
ID PERCEIVED WEIGHT DISCRIMINATION; DEPRESSIVE SYMPTOMS; METABOLIC
   SYNDROME; INSULIN-RESISTANCE; PHYSICAL HEALTH; BLOOD-PRESSURE; STRESS;
   STIGMA; CORTISOL; OVERWEIGHT
AB Objective: Obesity is associated with a range of negative psychological conditions that may also affect physiological health. Across two studies, we tested whether a range of psychological measures explain why obesity is prospectively associated with physiological dysregulation, measured via clinical indicators of cardiovascular, immune system, and metabolic function. Method: We used comparable 4-year follow-up representative longitudinal data of U.K. and U.S. older adults (=50 years) from the English Longitudinal Study of Ageing (2008/2009-2012/2013; Study 1; n = 6,250) and the Health and Retirement Study (2008/2010-2012/2014; Study 2; n = 9,664). A diverse range of psychological measures (e.g., depressive symptoms, life satisfaction, weight stigma, positive affect) were tested as candidate mediators in Studies 1 (n = 14) and 2 (n = 21). Results: Obesity predicted physiological dysregulation at follow-up across both studies. In Study 1, only weight stigma (measured between baseline and follow-up) explained 37% of the association between obesity and physiological dysregulation. In Study 2, only changes in weight stigma from baseline to follow-up (not baseline weight stigma) explained 13% of the effect of obesity on future physiological dysregulation. Mediation by weight stigma in both studies was partially attenuated when changes in body mass index from baseline to follow-up were controlled for. No other psychological measures explained the association between obesity and physiological dysregulation in either study. Conclusions: The prospective association between obesity and physiological dysregulation was largely not explained by psychological factors. However, experiencing weight stigma is associated with increased weight gain and this process may explain obesity-related declines in physiological health.
C1 [Putra, I. Gusti Ngurah Edi; Robinson, Eric] Univ Liverpool, Inst Populat Hlth, Dept Psychol, Liverpool, England.
   [Daly, Michael] Maynooth Univ, Dept Psychol, Maynooth, Ireland.
   [Steptoe, Andrew] Florida State Univ, Dept Behav Sci & Social Med, Coll Med, Tallahassee, FL USA.
   [Steptoe, Andrew] UCL, Inst Epidemiol & Hlth Care, Fac Populat Hlth Sci, Dept Behav Sci & Hlth, London, England.
   [Putra, I. Gusti Ngurah Edi] Univ Liverpool, Inst Populat Hlth, Dept Psychol, Bedford St South, Liverpool L69 7ZA, England.
C3 University of Liverpool; Maynooth University; State University System of
   Florida; Florida State University; University of London; University
   College London; University of Liverpool
RP Putra, IGNE (corresponding author), Univ Liverpool, Inst Populat Hlth, Dept Psychol, Bedford St South, Liverpool L69 7ZA, England.
EM ediputra.ign@gmail.com
RI Daly, Michael/AAD-7703-2019; Steptoe, Andrew/Y-2440-2019; Putra, I Gusti
   Ngurah Edi/AAG-2836-2020
OI Robinson, Eric/0000-0003-3586-5533; Steptoe, Andrew/0000-0001-7808-4943;
   Putra, I Gusti Ngurah Edi/0000-0002-1014-6949
FU Economic and Social Research Council (ESRC), a part of the United
   Kingdom Research and Innovation (UKRI) [ES/V017594/1]; National
   Institute on Aging [R01AG017644, 198/1047]; National Institute of Health
   and Care Research [NIA U01AG009740]; ESRC [ES/V017594/1] Funding Source:
   UKRI
FX This work received funding from the Economic and Social Research Council
   (ESRC), a part of the United Kingdom Research and Innovation (UKRI;
   ES/V017594/1). The English Longitudinal Study of Ageing is funded by the
   National Institute on Aging (R01AG017644) and by a consortium of UK
   Government Departments coordinated by the National Institute of Health
   and Care Research (198/1047). The Health and Retirement Study is
   sponsored by the National Institute on Aging (grant number NIA
   U01AG009740) and is conducted by the University of Michigan. The views
   stated in this work are of the authors only.
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NR 98
TC 5
Z9 5
U1 2
U2 14
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 0278-6133
EI 1930-7810
J9 HEALTH PSYCHOL
JI Health Psychol.
PD JUL
PY 2023
VL 42
IS 7
BP 472
EP 484
DI 10.1037/hea0001284
PG 13
WC Psychology, Clinical; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology
GA J8OK1
UT WOS:001012160800005
PM 37338426
OA Green Submitted, Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Calderón-DuPont, D
   Córdoba, SL
   Tello, JK
   Espinosa, A
   Guerrero, B
   Contreras, AV
   Morán-Ramosh, S
   Díaz-Villaseñor, A
AF Calderon-DuPont, Diana
   Romero-Cordoba, Sandra L.
   Tello, Jessica K.
   Espinosa, Aranza
   Guerrero, Brenda
   Contreras, Alejandra V.
   Moran-Ramosh, Sofia
   Diaz-Villasenor, Andrea
TI Impaired white adipose tissue fatty acid metabolism in mice fed a
   high-fat diet worsened by arsenic exposure, primarily affecting
   retroperitoneal adipose tissue
SO TOXICOLOGY AND APPLIED PHARMACOLOGY
LA English
DT Article
DE Fatty acid metabolism; Lipolysis; Insulin resistance; High-fat diet;
   Arsenic; White adipose tissue
ID INSULIN SENSITIVITY; OXIDATIVE STRESS; LIPOLYSIS; GLUCOSE; OBESITY;
   ADIPOCYTES; EXPRESSION; PROTEIN; GENE; DIFFERENTIATION
AB Fatty acid (FA) metabolism dysfunction of white adipose tissue (WAT) underlies obesity and insulin resistance in response to high calorie intake and/or endocrine-disrupting chemicals (EDCs), among other factors. Arsenic is an EDC that has been associated with metabolic syndrome and diabetes. However, the combined effect of a high-fat diet (HFD) and arsenic exposure on WAT FA metabolism has been little studied. FA metabolism was evaluated in visceral (epididymal and retroperitoneal) and subcutaneous WAT of C57BL/6 male mice fed control or HFD (12 and 40% kcal fat, respectively) for 16 weeks together with an environmentally relevant chronic arsenic exposure through drinking water (100 mu g/L) during the second half of the study. In mice fed HFD, arsenic potentiated the increase of serum markers of selective insulin resistance in WAT and fatty acid re-esterification and the decrease of the lipolysis index. Retroperitoneal was the WAT most affected, where the combination of arsenic and HFD in contrast to HFD, generated higher adipose weight, larger adipo-cytes, increased triglyceride content, and decreased fasting stimulated lipolysis evidenced by lower phosphor-ylation of HSL and perilipin. At the transcriptional level, arsenic in mice fed either diet downregulated genes involved in fatty acid uptake (LPL, CD36), oxidation (PPAR alpha, CPT1), lipolysis (ADRss3) and glycerol transport (AQP7 and AQP9). Additionally, arsenic potentiated hyperinsulinemia induced by HFD, despite a slight increase in weight gain and food efficiency. Thus, the second hit of arsenic in sensitized mice by HFD worsens fatty acid metabolism impairment in WAT, mainly retroperitoneal, along with an exacerbated insulin resistance phenotype.
C1 [Calderon-DuPont, Diana; Romero-Cordoba, Sandra L.; Tello, Jessica K.; Espinosa, Aranza; Guerrero, Brenda; Diaz-Villasenor, Andrea] Univ Nacl Autonoma Mexico, Inst Invest Biomed, Dept Med Genom & Toxicol Ambiental, Mexico City 04510, DF, Mexico.
   [Calderon-DuPont, Diana] Univ Nacl Autonoma Mexico, Doctorado Ciencias Biomed, Mexico City, Mexico.
   [Romero-Cordoba, Sandra L.] Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Bioquim, Mexico City 14000, Mexico.
   [Tello, Jessica K.] Univ Anahuac Campus Norte, Maestria Nutr Clin, Huixquilucan 52786, Estado De Mexic, Mexico.
   [Espinosa, Aranza; Guerrero, Brenda] Univ Nacl Autonoma Mexico, Fac Quim, Mexico City, Mexico.
   [Contreras, Alejandra V.] Inst Nacl Med Genom INMEGEN, Lab Nutrigenet & Nutrigen, Mexico City 14609, Mexico.
   [Contreras, Alejandra V.] Merck & Co Inc, Translat Mol Biomarkers, Rahway, NJ USA.
   [Moran-Ramosh, Sofia] Univ Nacl Autonoma Mexico, Inst Nacl Med Genom INMEGEN, Fac Quim, Unidad Genom Poblac Aplicada Salud, Mexico City 14609, Mexico.
   [Moran-Ramosh, Sofia] Univ Nacl Autonoma Mexico, Fac Quim, Dept Alimentos & Biotecnol, Mexico City, Mexico.
C3 Universidad Nacional Autonoma de Mexico; Universidad Nacional Autonoma
   de Mexico; Instituto Nacional de Ciencias Medicas y Nutricion Salvador
   Zubiran - Mexico; Universidad Nacional Autonoma de Mexico; Instituto
   Nacional de Medicina Genomica; Merck & Company; Merck & Company USA;
   Universidad Nacional Autonoma de Mexico; Instituto Nacional de Medicina
   Genomica; Universidad Nacional Autonoma de Mexico
RP Díaz-Villaseñor, A (corresponding author), Univ Nacl Autonoma Mexico, Inst Invest Biomed, Dept Med Genom & Toxicol Ambiental, Mexico City 04510, DF, Mexico.
EM diaz.villasenor@iibiomedicas.unam.mx
RI Contreras, Alejandra/E-7815-2013; Romero-Cordoba, Sandra/AAY-2625-2020;
   Romero-Cordoba, Sandra/A-2246-2014
OI Romero-Cordoba, Sandra/0000-0002-5591-696X
FU CONACyT [620872, IN216420]; PAPIIT (UNAM) [304038]
FX Diana Calderon-DuPont is a doctoral student from the Programa de
   Doctorado en Ciencias Biomedicas, Universidad Nacional Autonoma de
   Mexico (UNAM) and has received CONACyT PhD fellowship (620872) . This
   study was supported by grants from PAPIIT (UNAM) IN216420 To ADV and
   CONACyT 304038 to ADV and SMR. We greatly acknowledge the technical
   assistance of Dr. Ruth Gutierrez-Aguilar and B.S. Luz Maria Chiu.
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NR 97
TC 5
Z9 5
U1 0
U2 5
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0041-008X
EI 1096-0333
J9 TOXICOL APPL PHARM
JI Toxicol. Appl. Pharmacol.
PD JUN 1
PY 2023
VL 468
AR 116428
DI 10.1016/j.taap.2023.116428
EA MAY 2023
PG 17
WC Pharmacology & Pharmacy; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Toxicology
GA I0OT9
UT WOS:000999862300001
PM 36801214
DA 2025-06-11
ER

PT J
AU Sumara, A
   Stachniuk, A
   Montowska, M
   Kotecka-Majchrzak, K
   Grywalska, E
   Mitura, P
   Martinovic, LS
   Pavelic, SK
   Fornal, E
AF Sumara, Agata
   Stachniuk, Anna
   Montowska, Magdalena
   Kotecka-Majchrzak, Klaudia
   Grywalska, Ewelina
   Mitura, Przemyslaw
   Martinovic, Lara Saftic
   Pavelic, Sandra Kraljevic
   Fornal, Emilia
TI Comprehensive Review of Seven Plant Seed Oils: Chemical Composition,
   Nutritional Properties, and Biomedical Functions
SO FOOD REVIEWS INTERNATIONAL
LA English
DT Review
DE Edible oil; fatty acid; bioactive compound; medicinal plant; medical
   application; oil composition
ID EVENING PRIMROSE OIL; CUCURBITA-PEPO L.; SUPPLEMENTED HEMP-SEED;
   NIGELLA-SATIVA OIL; POLYCYCLIC AROMATIC-HYDROCARBONS;
   FATTY-ACID-COMPOSITION; HOT-NATURE DIET; SESAME OIL; DOUBLE-BLIND;
   OXIDATIVE STRESS
AB A suitable and balanced diet is a major factor determining human health and should comprise unprocessed food enriched with oilseed products containing bioactive components and fatty acids. This paper reviews the chemical compositions and biomedical functions of plant seed oils extracted from black cumin, evening primrose, hemp, milk thistle, sesame, flax, and pumpkin seeds. The review provides a comprehensive overview of current oil extracting techniques and of the composition and content of bioactive components, including fatty acids, phytosterols, tocopherols, phenols, and carotenoids. Moreover, we describe research findings on the medical applications, benefits and limitations of treatment with plant seed oils for diverse diseases such as mastalgia, premenstrual syndrome, menopause, diabetes, metabolic syndrome, cancer, and urinary tract and liver disease, as well as their use in dermatology and chemotherapy. The use of plant seed oils as topical agents and their anti-bacterial properties are reviewed, as well as important precautions in their medical applications. The information provided in this review is intended to serve as a compendium for medical professionals in the field of integrative medicine, nutrition, and dietetics, and to help consumers make the best use of plant seed oils in accordance with their medical and health needs. The review is also addressed to food control laboratories, as it provides detailed tabularised data on the components and their contents in the above-mentioned seven plant seed oils. These data are highly useful for the development of new analytical methods for testing the quality and authenticity of oils.
C1 [Sumara, Agata; Stachniuk, Anna; Fornal, Emilia] Med Univ Lublin, Dept Bioanalyt, Ul Jaczewskiego 8b, PL-20090 Lublin, Poland.
   [Montowska, Magdalena; Kotecka-Majchrzak, Klaudia] Poznan Univ Life Sci, Dept Meat Technol, Poznan, Poland.
   [Grywalska, Ewelina] Med Univ Lublin, Dept Expt Immunol, Lublin, Poland.
   [Mitura, Przemyslaw] Med Univ Lublin, Dept Urol & Urol Oncol, Lublin, Poland.
   [Martinovic, Lara Saftic] Univ Rijeka, Dept Biotechnol, Rijeka, Croatia.
   [Pavelic, Sandra Kraljevic] Univ Rijeka, Fac Hlth Studies, Rijeka, Croatia.
C3 Medical University of Lublin; Poznan University of Life Sciences;
   Medical University of Lublin; Medical University of Lublin; University
   of Rijeka; University of Rijeka
RP Fornal, E (corresponding author), Med Univ Lublin, Dept Bioanalyt, Ul Jaczewskiego 8b, PL-20090 Lublin, Poland.
EM emilia.fornal@umlub.pl
RI Fornal, Emilia/ABE-8988-2020; Montowska, Magdalena/AAL-9695-2020;
   Grywalska, Ewelina/MSX-0772-2025; Stachniuk, Anna/ABC-2418-2020; MITURA,
   PRZEMYSŁAW/GLS-1513-2022; Kraljevic Pavelic, Sandra/J-3864-2012; Saftic
   Martinovic, Lara/AAB-4389-2021
OI Kraljevic Pavelic, Sandra/0000-0003-0491-673X; Mitura,
   Przemyslaw/0000-0002-2021-4490; Fornal, Emilia/0000-0002-0503-0706;
   Saftic Martinovic, Lara/0000-0001-5637-4659; Kotecka,
   Klaudia/0000-0001-5109-6776; Montowska, Magdalena/0000-0002-6331-5726;
   Sumara, Agata/0000-0001-8677-7379; Stachniuk, Anna/0000-0001-6384-1999
FU Polish National Science Centre [2017/25/B/NZ9/02000]; University of
   Rijeka [uniri-biomed-18-133]
FX The study was supported by the Polish National Science Centre, [grant
   no. 2017/25/B/NZ9/02000] awarded to E. F., and the University of Rijeka
   research grant uniri-biomed-18-133 given to S. K. P.
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NR 195
TC 16
Z9 16
U1 9
U2 87
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 8755-9129
EI 1525-6103
J9 FOOD REV INT
JI Food Rev. Int.
PD SEP 8
PY 2023
VL 39
IS 8
BP 5402
EP 5422
DI 10.1080/87559129.2022.2067560
EA MAY 2022
PG 21
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA S9EL1
UT WOS:000793919100001
DA 2025-06-11
ER

PT J
AU Lin, YJ
   Fan, R
   Hao, ZJ
   Li, JT
   Yang, XL
   Zhang, Y
   Xia, YL
AF Lin, Yajuan
   Fan, Rui
   Hao, Zhujing
   Li, Jiatian
   Yang, Xiaolei
   Zhang, Ying
   Xia, Yunlong
TI The Association Between Physical Activity and Insulin Level Under
   Different Levels of Lipid Indices and Serum Uric Acid
SO FRONTIERS IN PHYSIOLOGY
LA English
DT Article
DE physical activity; insulin; NHANES; SUA; lipids
ID DEPENDENT DIABETES-MELLITUS; IMPAIRED FASTING GLUCOSE; METABOLIC
   SYNDROME; OXIDATIVE STRESS; PREDICTING MORTALITY; HEPATIC STEATOSIS;
   VISCERAL FAT; FOLLOW-UP; RESISTANCE; EXERCISE
AB ObjectivesInsulin resistance (IR) has been shown to play important role in the pathogenesis of type 2 diabetes mellitus (T2DM). There is an intricate interplay between IR, dyslipidemia, and serum uric acid (SUA) in people with and without diabetes. Physical activity has a positive impact on insulin sensitivity in insulin-resistant populations. However, the effect of different intensities of physical activity on insulin levels under different lipid indices and SUA levels is unclear. MethodsTo explore the association between physical activity and insulin, we enrolled 12,982 participants aged above 18 years from the National Health and Nutrition Examination Survey (NHANES) conducted between 2009 and 2018. Next, we conducted multivariate logistic regression analyses, generated fitted smoothing curves, and visualized the data using generalized additive models. ResultsIncreased intensities of physical activity can significantly reduce insulin levels. The association between physical activity and insulin persisted even after adjusting for confounding factors, with beta value (95% CI) = -17.10 (-21.64, -12.56) in moderate group, beta value (95% CI) = -28.60 (-33.08, -24.11) in high group, respectively. High-intensity physical activity significantly lowered insulin levels in the lower and higher SUA tertiles, and three tertiles of LDL-c, HDL-c, and TG. Moreover, the link between physical activity and insulin was stronger in male individuals. ConclusionThis study shows that physical activity can significantly lower insulin levels, and high-intensity physical activity still has additional potential benefits for insulin levels, even in the condition of dyslipidemia and hyperuricemia.
C1 [Lin, Yajuan; Fan, Rui; Hao, Zhujing; Li, Jiatian; Yang, Xiaolei; Zhang, Ying; Xia, Yunlong] Dalian Med Univ, Affiliated Hosp 1, Dept Cardiol, Dalian, Peoples R China.
C3 Dalian Medical University
RP Zhang, Y; Xia, YL (corresponding author), Dalian Med Univ, Affiliated Hosp 1, Dept Cardiol, Dalian, Peoples R China.
EM zy114129@sina.com; yunlong_xia@126.com
RI liu, liu/JEO-6900-2023; fan, rui/IQS-7247-2023
FU National Natural Science Foundation of China [81900439, 81970286]; Major
   Program of Science and Technology of Liaoning [2021JH1/10400050];
   Science Foundation of Doctors of Liaoning Province [2020-BS-197]; Chang
   Jiang Scholars Program [T2017124]; Dalian Talents Innovation Supporting
   Project [2018RD09]
FX Funding This research was funded by the National Natural Science
   Foundation of China (grant numbers 81900439 and 81970286), the Major
   Program of Science and Technology of Liaoning (2021JH1/10400050), the
   Science Foundation of Doctors of Liaoning Province (grant number
   2020-BS-197), the Chang Jiang Scholars Program (grant number T2017124),
   and the Dalian Talents Innovation Supporting Project (grant number
   2018RD09).
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NR 71
TC 20
Z9 21
U1 0
U2 14
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1664-042X
J9 FRONT PHYSIOL
JI Front. Physiol.
PD FEB 2
PY 2022
VL 13
AR 809669
DI 10.3389/fphys.2022.809669
PG 12
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA ZF9DF
UT WOS:000759867800001
PM 35185617
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Caceres, BA
   Britton, LE
   Cortes, YI
   Makarem, N
   Suglia, SF
AF Caceres, Billy A.
   Britton, Laura E.
   Cortes, Yamnia, I
   Makarem, Nour
   Suglia, Shakira F.
TI Investigating the associations between childhood trauma and
   cardiovascular health in midlife
SO JOURNAL OF TRAUMATIC STRESS
LA English
DT Article
ID INTIMATE PARTNER VIOLENCE; GENDER-DIFFERENCES; METABOLIC SYNDROME;
   BLOOD-PRESSURE; SLEEP QUALITY; RISK-FACTORS; ABUSE; STRESS; DISEASE;
   WOMEN
AB Growing evidence suggests that childhood trauma is associated with poorer cardiovascular health in adulthood, but few studies have examined potential mediators of these associations. We examined the links between different forms of childhood trauma (i.e., abuse, neglect, cumulative trauma) and cardiovascular health and explored potential mediators. Cross-sectional data from 1,251 participants in the National Survey of Midlife Development in the United States' II Biomarker Project were analyzed. Path analyses were conducted to examine the associations between childhood trauma and cardiovascular health (i.e., American Heart Association's Life's Simple 7 [LS7] score). Depressive symptoms and sleep quality were explored as potential mediators, and exploratory analyses examined whether these associations were moderated by sex. Women reported more severe childhood emotional and sexual abuse and emotional neglect, p p = .018, and higher LS7 scores, p = .027, than men. Path analyses demonstrated the total effects of increasing severity of all forms of childhood trauma with LS7 scores were significant, and cumulative childhood trauma was inversely associated with LS7 score Bs = -0.306- -0.076, p p = .048. The range of total effects of different forms of childhood trauma on LS7 scores mediated by depressive symptoms and sleep quality was 26.8%-57.5%. Sex moderated the associations between all forms of childhood trauma and cardiovascular health. Longitudinal studies are needed that examine mediators of the associations between childhood trauma and cardiovascular health. Findings suggest sex-specific, trauma-informed approaches for cardiovascular disease prevention in adults exposed to childhood trauma may be needed.
C1 [Caceres, Billy A.; Britton, Laura E.] Columbia Univ, Sch Nursing, New York, NY USA.
   [Cortes, Yamnia, I] Univ N Carolina, Sch Nursing, Chapel Hill, NC 27515 USA.
   [Makarem, Nour] Columbia Univ, Mailman Sch Publ Hlth, Dept Epidemiol, Irving Med Ctr, New York, NY USA.
   [Suglia, Shakira F.] Emory Univ, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA.
C3 Columbia University; University of North Carolina; University of North
   Carolina Chapel Hill; Columbia University; NewYork-Presbyterian
   Hospital; Emory University; Rollins School Public Health
RP Caceres, BA (corresponding author), 560 West 168th St,Room 603, New York, NY 10032 USA.
EM bac2134@cumc.columbia.edu
RI Makarem, Nour/JTU-0953-2023
OI Cortes, Yamnia I./0000-0003-1520-2775; Caceres,
   Billy/0000-0001-6865-5546; Britton, Laura/0000-0003-4051-3751
FU National Institute of Nursing Research [T32NR007969, T32NR014205];
   National Institute onAging [P01AG020166]; National Institute
   onMinorityHealth and Health Disparities [K23MD014767]; National Heart,
   Lung, and Blood Institute [K01HL146965, K99HL148511, R00HL148511,
   R25HL10544]; National Heart Lung and Blood Institute [R00HL148511]
   Funding Source: NIH RePORTER; National Institute on Minority Health and
   Health Disparities [K23MD014767] Funding Source: NIH RePORTER
FX National Institute of Nursing Research, Grant/Award Numbers:
   T32NR007969, T32NR014205; National Institute onAging, Grant/Award
   Number: P01AG020166; National Institute onMinorityHealth and Health
   Disparities, Grant/Award Number: K23MD014767; National Heart, Lung, and
   Blood Institute, Grant/Award Numbers: K01HL146965, K99HL148511,
   R00HL148511, R25HL10544
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NR 67
TC 8
Z9 9
U1 1
U2 11
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0894-9867
EI 1573-6598
J9 J TRAUMA STRESS
JI J. Trauma Stress
PD APR
PY 2022
VL 35
IS 2
BP 409
EP 423
DI 10.1002/jts.22752
EA NOV 2021
PG 15
WC Psychology, Clinical; Psychiatry
WE Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA 0O7HR
UT WOS:000720646400001
PM 34800058
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Chang, GRE
   Hsieh, WS
   Chou, LS
   Lin, CS
   Wu, CF
   Lin, JW
   Lin, WL
   Lin, ZC
   Liao, HEY
   Kao, CY
   Lin, CEF
AF Chang, Geng-Ruei
   Hsieh, Wen-Tsong
   Chou, Lan-Szu
   Lin, Chen-Si
   Wu, Ching-Fen
   Lin, Jen-Wei
   Lin, Wei-Li
   Lin, Tzu-Chun
   Liao, Huei-Jyuan
   Kao, Chen-Yung
   Lin, Chuen-Fu
TI Curcumin Improved Glucose Intolerance, Renal Injury, and Nonalcoholic
   Fatty Liver Disease and Decreased Chromium Loss through Urine in Obese
   Mice
SO PROCESSES
LA English
DT Article
DE curcumin; chromium; fatty liver; glucose intolerance; renal injury;
   obesity
ID INSULIN-RESISTANCE; OXIDATIVE STRESS; DOUBLE-BLIND; METABOLIC SYNDROME;
   INFLAMMATION; PROTECTS; BLOOD; ACCUMULATION; MUSCLE; KIDNEY
AB Obesity-associated hyperglycemia underlies insulin resistance, glucose intolerance, and related metabolic disorders including type 2 diabetes, renal damage, and nonalcoholic fatty liver disease. Turmeric root is commonly used in Asia, and curcumin, one of its pharmacological components, can play a role in preventing and treating certain chronic physiological disorders. Accordingly, this study examined how high-fat diet (HFD)-induced hyperglycemia and hyperlipidemia are reduced by curcumin through changes in fatty liver scores, chromium distribution, and renal injury in mice. Relative to the control group, also fed an HFD, the curcumin group weighed less and had smaller adipocytes; it also had lower daily food efficiency, blood urea nitrogen and creatinine levels, serum alanine aminotransferase and aspartate aminotransferase levels, serum and hepatic triglyceride levels, and hepatic lipid regulation marker expression. The curcumin-treated obese group exhibited significantly lower fasting blood glucose, was less glucose intolerant, had higher Akt phosphorylation and glucose transporter 4 (GLUT4) expression, and had greater serum insulin levels. Moreover, the group showed renal damage with lower TNF-alpha expression along with more numerous renal antioxidative enzymes that included superoxide dismutase, glutathione peroxidase, and catalase. The liver histology of the curcumin-treated obese mice showed superior lipid infiltration and fewer FASN and PNPLA3 proteins in comparison with the control mice. Curcumin contributed to creating a positive chromium balance by decreasing the amount of chromium lost through urine, leading to the chromium mobilization needed to mitigate hyperglycemia. Thus, the results suggest that curcumin prevents HFD-induced glucose intolerance, kidney injury, and nonalcoholic fatty liver disease.
C1 [Chang, Geng-Ruei; Wu, Ching-Fen; Lin, Tzu-Chun; Liao, Huei-Jyuan; Kao, Chen-Yung] Natl Chiayi Univ, Dept Vet Med, 580 Xinmin Rd, Chiayi 60054, Taiwan.
   [Hsieh, Wen-Tsong] China Med Univ, Dept Pharmacol, 91 Hsueh Shih Rd, Taichung 404333, Taiwan.
   [Hsieh, Wen-Tsong] China Med Univ, Chinese Med Res Ctr, 91 Hsueh Shih Rd, Taichung 404333, Taiwan.
   [Hsieh, Wen-Tsong] China Med Univ, Drug Dev Ctr, 91 Hsueh Shih Rd, Taichung 404333, Taiwan.
   [Chou, Lan-Szu] Natl Chiayi Univ, Dept BioAgr Sci, 300 Syuefu Rd, Chiayi 60004, Taiwan.
   [Lin, Chen-Si] Natl Taiwan Univ, Sch Vet Med, 4 Sect,1 Roosevelt Rd, Taipei 10617, Taiwan.
   [Lin, Jen-Wei; Lin, Wei-Li] Hungkuang Univ, Bachelor Degree Program Anim Healthcare, 6 Sect,1018 Taiwan Blvd, Taichung 433304, Taiwan.
   [Lin, Wei-Li] Chaoyang Univ Technol, Gen Educ Ctr, 168 Jifeng Eastern Rd, Taichung 413310, Taiwan.
   [Lin, Chuen-Fu] Natl Pingtung Univ Sci & Technol, Coll Vet Med, Dept Vet Med, 1 Shuefu Rd, Pingtung 912301, Taiwan.
C3 China Medical University Taiwan; China Medical University Taiwan; China
   Medical University Taiwan; National Chiayi University; National Taiwan
   University; Hungkuang University; Chaoyang University of Technology;
   National Pingtung University Science & Technology
RP Lin, CEF (corresponding author), Natl Pingtung Univ Sci & Technol, Coll Vet Med, Dept Vet Med, 1 Shuefu Rd, Pingtung 912301, Taiwan.
EM grchang@mail.ncyu.edu.tw; wthsieh@mail.cmu.edu.tw;
   choulb@mail.ncyu.edu.tw; cslin100@ntu.edu.tw; cfwu@mail.ncyu.edu.tw;
   jenweilin@hk.edu.tw; ivorylily99@gmail.com; lin890090@gmail.com;
   pipi324615@gmail.com; wg141319@gmail.com; cflin2283@mail.npust.edu.tw
RI Hsieh, Wen-Tsong/AAY-3089-2020; LIN, CHEN-SI/AAD-3733-2019
OI LIN, CHEN-SI/0000-0003-2254-8344; Hsieh, Wen-Tsong/0000-0002-2330-8898;
   Chang, Geng-Ruei/0000-0003-0577-3339
FU National Chiayi University (Taiwan) [110A3-038]
FX This study was supported in part by Grant 110A3-038 from the National
   Chiayi University (Taiwan).
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NR 66
TC 10
Z9 11
U1 8
U2 30
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2227-9717
J9 PROCESSES
JI Processes
PD JUL
PY 2021
VL 9
IS 7
AR 1132
DI 10.3390/pr9071132
PG 20
WC Engineering, Chemical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering
GA TO5XK
UT WOS:000676983900001
OA gold
DA 2025-06-11
ER

PT J
AU Sun, RB
   Xu, D
   Wei, QL
   Zhang, BL
   Aa, JY
   Wang, GJ
   Xie, Y
AF Sun, Runbin
   Xu, Dan
   Wei, Qingli
   Zhang, Bangling
   Aa, Jiye
   Wang, Guangji
   Xie, Yuan
TI Silybin ameliorates hepatic lipid accumulation and modulates global
   metabolism in an NAFLD mouse model
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Article
DE NAFLD; Silybin; TUDCA; Metabolomics; GC/MS
ID FATTY-LIVER-DISEASE; OXIDATIVE STRESS; NONALCOHOLIC STEATOHEPATITIS;
   BIOMARKER DISCOVERY; MICE; METABOLOMICS; PATHOGENESIS; STEATOSIS;
   SILYMARIN; DIAGNOSIS
AB Silybin shows good effects against obesity and metabolic syndrome, but the systemic modulation effect of silybin has not been fully revealed. This study aims to investigate the metabolic regulation by silybin of nonalcoholic fatty liver disease (NAFLD). C57BL/6 J mice were fed a high-fat/high-cholesterol diet for 8 weeks and treated with silybin (50 or 100 mg/kg/day) and sodium tauroursodeoxycholate (TUDCA, 50 mg/kg/day) by gavage for the last 4 weeks. Blood biochemical indexes and hepatic lipid measurement as well as Oil red O staining of the liver were conducted to evaluate the model and the lipid-lowering effect of silybin and TUDCA. Furthermore, serum and liver samples were detected by a metabolomic platform based on gas chromatography-mass spectrometry (GC/MS). Multivariate/univariate data analysis and pathway analysis were used to investigate differential metabolites and metabolic pathways. The results showed that the mouse NAFLD model was established successfully and that silybin and TUDCA significantly lowered both serum and hepatic lipid accumulation. Metabolomic analysis of serum and liver showed that a high-fat/high-cholesterol diet caused abnormal metabolism of metabolites involved in lipid metabolism, polyol metabolism, amino acid metabolism, the urea cycle and the TCA cycle. Silybin and TUDCA treatment both reversed metabolic disorders caused by HFD feeding. In conclusion, a high-fat/high-cholesterol diet caused metabolic abnormalities in the serum and liver of mice, and silybin treatment improved hepatic lipid accumulation and modulated global metabolic pathways, which provided a possible explanation of its multiple target mechanism.
C1 [Sun, Runbin; Wei, Qingli; Zhang, Bangling; Aa, Jiye; Wang, Guangji; Xie, Yuan] China Pharmaceut Univ, Key Lab Drug Metab & Pharmacokinet, State Key Lab Nat Med, Nanjing 210009, Peoples R China.
   [Xu, Dan] Nanjing Chia Tai Tianqing Pharmaceut Co Ltd, Res & Dev Ctr, Nanjing 210038, Peoples R China.
C3 China Pharmaceutical University
RP Wang, GJ; Xie, Y (corresponding author), China Pharmaceut Univ, Key Lab Drug Metab & Pharmacokinet, State Key Lab Nat Med, Nanjing 210009, Peoples R China.
EM guangjiwang@hotmail.com; yuanxie58@yahoo.com
RI Wang, Jiani/G-8591-2019
OI Wang, Guangji/0000-0002-0777-3896
FU National Natural Science Foundation of China [81673679, 81872932,
   81703601]; China Postdoctoral Science Foundation [2018M632429]; "Double
   First-Class" University [CPU2018GF01]
FX This project was supported by the National Natural Science Foundation of
   China (No. 81673679, 81872932, 81703601), "Double First-Class"
   University project (CPU2018GF01) and the China Postdoctoral Science
   Foundation (2018M632429).
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NR 48
TC 52
Z9 55
U1 0
U2 38
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD MAR
PY 2020
VL 123
AR 109721
DI 10.1016/j.biopha.2019.109721
PG 10
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA KF8HB
UT WOS:000509476800073
PM 31865143
OA gold
DA 2025-06-11
ER

PT J
AU Pai, SA
   Munshi, RP
   Panchal, FH
   Gaur, IS
   Juvekar, AR
AF Pai, Sarayu A.
   Munshi, Renuka P.
   Panchal, Falguni H.
   Gaur, Ila-Shruti
   Juvekar, Archana R.
TI Chrysin ameliorates nonalcoholic fatty liver disease in rats
SO NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
LA English
DT Article
DE Chrysin; Nonalcoholic fatty liver disease; Nonalcoholic steatohepatitis;
   SREBP-1c; PPAR-alpha
ID OXIDATIVE STRESS; INDUCED HEPATOTOXICITY; LIPID-METABOLISM; MESANGIAL
   CELLS; INJURY; PATHOGENESIS; INFLAMMATION; ALLEVIATION; TISSUE; MODEL
AB Nonalcoholic fatty liver disease (NAFLD) is regarded as the hepatic manifestation of the metabolic syndrome. It begins with the accumulation of fat in the liver (simple steatosis), which if untreated can progress to nonalcoholic steatohepatitis, cirrhosis, and hepatocellular carcinoma. Chrysin is a flavonoid present in bee propolis and many other plants. The objective of this study was to determine if chrysin can ameliorate NAFLD induced by feeding a high fructose diet (HFD) in rats. The rats were divided into five groups: normal control, HFD control, chrysin (25, 50, and 100 mg/kg p.o. body weight). Biochemical estimations were carried out in the serum and liver of rats. The gene expressions of SREBP-1c and PPAR alpha were determined in the liver. The histopathology of the liver was also studied. Chrysin caused a significant decrease in the serum fasting glucose and improved the insulin resistance, dyslipidemia, and liver enzymes. It caused a significant decrease in the liver weight and hepatic free fatty acids, triglyceride, and cholesterol content. Chrysin exerted antioxidant effects, reduced carbonyl content, advanced glycation end products, collagen, TNF-alpha, and IL-6 concentrations in the liver. Chrysin significantly reduced the hepatic gene expression of SREBP-1c and increased that of PPAR-alpha. The histopathology of liver of rats treated with chrysin showed significant decrease in the steatosis, ballooning, and lobular inflammation when compared to the HFD control group. Thus, chrysin demonstrated anti-steatotic, antiglycating, antioxidant, anti-inflammatory, and antifibrotic effects and seems to be a promising molecule for the management of NAFLD.
C1 [Pai, Sarayu A.; Juvekar, Archana R.] Inst Chem Technol, Pharmacol Res Lab1, Dept Pharmaceut Sci & Technol, NP Marg, Mumbai 400019, Maharashtra, India.
   [Munshi, Renuka P.; Panchal, Falguni H.; Gaur, Ila-Shruti] TN Med Coll & BYL Nair Ch Hosp, Dept Clin Pharmacol, Dr AL Nair Rd, Mumbai 400008, Maharashtra, India.
   [Munshi, Renuka P.; Panchal, Falguni H.; Gaur, Ila-Shruti] BYL Nair Charitable Hosp, Dr AL Nair Rd, Mumbai 400008, Maharashtra, India.
C3 Institute of Chemical Technology - Mumbai; Topiwala National Medical
   College & B Y L Nair Charitable Hospital; Topiwala National Medical
   College & B Y L Nair Charitable Hospital
RP Juvekar, AR (corresponding author), Inst Chem Technol, Pharmacol Res Lab1, Dept Pharmaceut Sci & Technol, NP Marg, Mumbai 400019, Maharashtra, India.
EM drarchana.juvekar@gmail.com
OI Pai, Sarayu/0000-0001-5861-3975
FU University Grants Commission, New Delhi, India [F.25-1/2014-15 (BSR),
   F.5-63/2007 (BSR)]
FX This work was supported by a grant from the University Grants
   Commission, New Delhi, India (Letter no.F.25-1/2014-15 (BSR)/No.
   F.5-63/2007 (BSR) dated 16 February 2015).
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NR 52
TC 43
Z9 45
U1 1
U2 32
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0028-1298
EI 1432-1912
J9 N-S ARCH PHARMACOL
JI Naunyn-Schmiedebergs Arch. Pharmacol.
PD DEC
PY 2019
VL 392
IS 12
BP 1617
EP 1628
DI 10.1007/s00210-019-01705-3
PG 12
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA JL8UB
UT WOS:000495801700013
PM 31372694
DA 2025-06-11
ER

PT J
AU Onuh, JO
   Aluko, RE
AF Onuh, John O.
   Aluko, Rotimi E.
TI Metabolomics as a tool to study the mechanism of action of bioactive
   protein hydrolysates and peptides: A review of current literature
SO TRENDS IN FOOD SCIENCE & TECHNOLOGY
LA English
DT Review
DE Metabolomics; Biomarkers; Hypertension; Bioactive peptides; Protein
   hydrolysates
ID I-CONVERTING-ENZYME; SPONTANEOUSLY HYPERTENSIVE-RATS; VITRO ANTIOXIDANT
   PROPERTIES; BLOOD-PRESSURE; INHIBITORY PEPTIDE; MASS-SPECTROMETRY;
   IDENTIFICATION; RENIN; L.; RESPONSES
AB Background: Metabolomics deals with the study of low molecular weight compounds and metabolites in biological fluids, tissues and organs. It is a relatively new and evolving field that is useful in the prediction of several biomarkers of food intake, diseases and drug toxicity at the cellular level. It has been applied to study chronic health conditions such as hypertension, cancer, oxidative stress, cardiovascular diseases, metabolic syndrome, obesity and diabetes as well as food composition, nutritional assessment and food quality. However, very limited studies have been reported on the application of metabolomics profiling of the physiological effects of food bioactive peptides and protein hydrolysates.
   Scope and approach: This review discusses the importance of metabolite profiling of the physiological effects of food bioactive peptides and protein hydrolysates and associated regulatory mechanisms. Food bioactive peptides and protein hydrolysates are important because of the numerous vital physiological roles they play in human health and diseases. Metabolite profiling of in vivo changes will provide better understanding of the pathogenesis of disease conditions and the regulatory mechanisms of action of bioactive peptides and protein hydrolysates involved in the attenuation of these conditions.
   Key findings and conclusions: The study provides information on several metabolite changes and potential mechanisms of action associated with the consumption of bioactive peptides and protein hydrolysates. It also offered an understanding of the regulatory pathways involved in the attenuation of several disease conditions by food bioactive peptides and protein hydrolysates as well as assisting in the development of biomarkers.
C1 [Onuh, John O.] Univ Georgia, Ctr Mol & Translat Med, 100 Piedmont Ave SE, Atlanta, GA 30303 USA.
   [Aluko, Rotimi E.] Univ Manitoba, Dept Food & Human Nutr Sci, Winnipeg, MB R3T 2N2, Canada.
C3 University System of Georgia; University of Georgia; University of
   Manitoba
RP Aluko, RE (corresponding author), Univ Manitoba, Dept Food & Human Nutr Sci, Winnipeg, MB R3T 2N2, Canada.
EM jonuh@gsu.edu; rotimi.aluko@umanitoba.ca
RI Aluko, Rotimi/HPG-2631-2023; Onuh, John/JRX-3218-2023
OI Onuh, John/0000-0002-0514-8720
FU Natural Sciences and Engineering Research Council of Canada (NSERC)
   [RGPIN 2018-06019]; Cette recherche a ete financee par le Conseil de
   recherches en sciences naturelles et en genie du Canada (CRSNG) [RGPIN
   2018-06019]
FX We acknowledge support of the Natural Sciences and Engineering Research
   Council of Canada (NSERC), funding reference number RGPIN 2018-06019.
   Cette recherche a ete financee par le Conseil de recherches en sciences
   naturelles et en genie du Canada (CRSNG), numero de reference RGPIN
   2018-06019.
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NR 71
TC 28
Z9 30
U1 7
U2 89
PU ELSEVIER SCIENCE LONDON
PI LONDON
PA 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND
SN 0924-2244
J9 TRENDS FOOD SCI TECH
JI Trends Food Sci. Technol.
PD SEP
PY 2019
VL 91
BP 625
EP 633
DI 10.1016/j.tifs.2019.08.002
PG 9
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA IW3GW
UT WOS:000484869500052
DA 2025-06-11
ER

PT J
AU Chen, CC
   Lee, TY
   Leu, YL
   Wang, SH
AF Chen, Chin-Chuan
   Lee, Ting-Yau
   Leu, Yann-Lii
   Wang, Shu-Huei
TI Pigment epithelium-derived factor inhibits adipogenesis in 3T3-L1
   adipocytes and protects against high-fat diet-induced obesity and
   metabolic disorders in mice
SO TRANSLATIONAL RESEARCH
LA English
   English
DT Article
ID INSULIN-RESISTANCE; FACTOR PEDF; OXIDATIVE STRESS; ADIPOSE-TISSUE;
   SERUM-LEVELS; INFLAMMATION; CANCER; GROWTH; ADIPONECTIN; EXPRESSION
AB Obesity is a major cause of metabolic syndrome and type II diabetes, and it presents with metabolic disorders, such as hyperglycemia, hyperlipidemia, and insulin resistance. Pigment epithelium-derived factor (PEDF), a protein isolated from retinal pigment epithelial cells, has multiple functions, including neuronal protection, antineoplastic effects, and anti-inflammatory activity. The aim of this study is to investigate the antiobesity effects of PEDF. The antiobesity effects of PEDF on fat accumulation, inflammation, energy expenditure, insulin resistance, and obesity-related physiological parameters and protein levels were assessed in high-fat diet (HFD)-induced obese mice in vivo and in 3T3-L1 adipocytes, palmitate (PA)-treated HepG2 cells, and C2C12 myotubes in vitro. In an in vivo assay, PEDF effectively decreased body weight gain, white adipose tissue mass, and inflammation and improved insulin resistance, dyslipidemia, and hyperglycemia in HFD-induced mice. In liver tissue, PEDF decreased lipid accumulation and fibrosis. In an in vitro assay, PEDF diminished the differentiation of 3T3-L1 preadipocytes. We also determined that PEDF promoted lipolysis and prolonged cell cycle progression, through the mTOR-S6K pathway and downstream transcription factors, such as peroxisome proliferator-activated receptor gamma, CCAAT/enhancer-binding protein alpha (CEBP-alpha), and CEBP-beta. In addition, PEDF decreased reactive oxygen species production in PA-induced HepG2 cells and improved glucose uptake ability in PA-induced HepG2 cells and C2C12 myotubes. In the present study, PEDF protected against HFD-induced obesity and metabolic disorders in mice, inhibited adipogenesis, and improved insulin resistance. These results provide a new potential treatment for obesity in the future.
C1 [Chen, Chin-Chuan; Leu, Yann-Lii] Chang Gung Univ, Grad Inst Nat Prod, Taoyuan, Taiwan.
   [Chen, Chin-Chuan] Chang Gung Mem Hosp, Tissue Bank, Taoyuan, Taiwan.
   [Lee, Ting-Yau; Wang, Shu-Huei] Natl Taiwan Univ, Dept Anat & Cell Biol, Coll Med, 1,Sect 1,Ren Ai Rd, Taipei 100, Taiwan.
   [Leu, Yann-Lii] Chang Gung Univ, Hlth Aging Res Ctr, Chinese Herbal Med Res Team, Taoyuan, Taiwan.
   Chang Gung Mem Hosp, Ctr Tradit Chinese Med, Taoyuan, Taiwan.
C3 Chang Gung University; Chang Gung Memorial Hospital; National Taiwan
   University; Chang Gung University; Chang Gung Memorial Hospital
RP Wang, SH (corresponding author), Natl Taiwan Univ, Dept Anat & Cell Biol, Coll Med, 1,Sect 1,Ren Ai Rd, Taipei 100, Taiwan.
EM shwang@ntu.edu.tw
RI Wang, Hui-Min/C-5539-2009; Chen, Chin-Chuan/G-3094-2013
OI WANG, SHU-HUEI/0000-0002-9208-3135; Chen, Chin-Chuan/0000-0002-8938-3209
FU Ministry of Science and Technology, Taiwan [MOST 106-2320-B-002-015]
FX This work was supported by grants from the Ministry of Science and
   Technology, Taiwan (MOST 106-2320-B-002-015).
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NR 60
TC 13
Z9 15
U1 0
U2 30
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1931-5244
EI 1878-1810
J9 TRANSL RES
JI Transl. Res.
PD AUG
PY 2019
VL 210
BP 26
EP 42
DI 10.1016/j.trsl.2019.04.006
PG 17
WC Medical Laboratory Technology; Medicine, General & Internal; Medicine,
   Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology; General & Internal Medicine; Research &
   Experimental Medicine
GA IF3NA
UT WOS:000472986300003
PM 31121128
DA 2025-06-11
ER

PT J
AU Abbaspour, N
   Roberts, T
   Hooshmand, S
   Kern, M
   Hong, MY
AF Abbaspour, Nazanin
   Roberts, Traci
   Hooshmand, Shirin
   Kern, Mark
   Hong, Mee Young
TI Mixed Nut Consumption May Improve Cardiovascular Disease Risk Factors in
   Overweight and Obese Adults
SO NUTRIENTS
LA English
DT Article
DE mixed nuts; cholesterol; glucose; insulin; randomized controlled trial
ID OXIDATIVE STRESS; BODY-COMPOSITION; INFLAMMATORY MARKERS;
   INSULIN-RESISTANCE; ALMOND CONSUMPTION; METABOLIC SYNDROME; LIPID
   PROFILES; PISTACHIO NUTS; SERUM-LIPIDS; DIETARY
AB Emerging research indicates that nuts are a source of health-promoting compounds demonstrating cardioprotective benefits. However, most studies have assessed the effect of single nuts rather than a nut mixture. The objective of this study was, therefore, to examine the effect of mixed-nut consumption on cardiovascular disease (CVD) risk factors in overweight and obese adults. In a randomized, parallel-arm, controlled trial, 48 participants consumed isocaloric (250 kcal) amounts of pretzels or mixed-nuts. Body weight (BW) (p = 0.024), BMI (p = 0.043), and insulin levels (p = 0.032) were significantly lower in the nut group compared to the pretzel group. Mixed-nut consumption also significantly reduced glucose (p = 0.04) and insulin (p = 0.032) levels after 4 and 8 weeks compared to baseline, respectively. Lactate dehydrogenase of the nut group was significantly lower than the pretzel group (p = 0.002). No significant differences were detected between groups for triglycerides, LDL-C, and HDL-C. However, pretzel consumption increased triglycerides (p = 0.048) from 4 weeks to 8 weeks. Moreover, LDL-C increased (p = 0.038) while HDL-C transiently decreased (p = 0.044) from baseline to 4 weeks. No significant lipid changes were detected within the nut group. Our results suggest that supplementing the diet with mixed-nuts could improve CVD risk factors by improving BW and glucose regulation in comparison to a common carbohydrate-rich snack without promoting the negative effects on lipids detected with pretzels.
C1 [Abbaspour, Nazanin; Roberts, Traci; Hooshmand, Shirin; Kern, Mark; Hong, Mee Young] San Diego State Univ, Sch Exercise & Nutr Sci, San Diego, CA 92182 USA.
C3 California State University System; San Diego State University
RP Hong, MY (corresponding author), San Diego State Univ, Sch Exercise & Nutr Sci, San Diego, CA 92182 USA.
EM mhong2@sdsu.edu
FU American Heart Association [16GRNT31360007]; American Heart Association
   (AHA) [16GRNT31360007] Funding Source: American Heart Association (AHA)
FX This study was funded by the American Heart Association, grant number
   16GRNT31360007.
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NR 62
TC 32
Z9 34
U1 1
U2 26
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JUL
PY 2019
VL 11
IS 7
AR 1488
DI 10.3390/nu11071488
PG 13
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA IN7TT
UT WOS:000478885400054
PM 31261928
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Talbot, CPJ
   Dolinsky, VW
AF Talbot, Charlotte Pauline Joelle
   Dolinsky, Vernon Wayne
TI Sex differences in the developmental origins of cardiometabolic disease
   following exposure to maternal obesity and gestational diabetes
SO APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
LA English
DT Review
DE gestational diabetes; maternal obesity; cardiometabolic disease;
   Developmental Origins of Health and Disease; endocrine hormones;
   estrogen; testosterone; insulin resistance; metabolism
ID GENDER-DIFFERENCES; INSULIN-RESISTANCE; FETAL SEX; METABOLIC-SYNDROME;
   FAT DISTRIBUTION; RISK-FACTORS; BODY-FAT; WOMEN; MELLITUS; GLUCOSE
AB Over the past 30 years, the worldwide prevalence of obesity has nearly doubled. In addition, more and more women in their child-bearing years are overweight or obese, which increases the risk of gestational diabetes mellitus (GDM). It is increasingly accepted by the scientific community that early life exposure to environmental stress influences the long-term health of an individual, which has been termed the Developmental Origins of Health and Disease theory. Evidence from human cohorts and epidemiological and animal studies has shown that maternal obesity and GDM condition the offspring for cardiometabolic disease development. These effects are most likely regulated by epigenetic mechanisms; however, biological sex is an important factor in defining the risk of the development of several metabolic health disorders. The aim of this review is to describe the current evidence from human cohort and animal model studies that implicates sex differences in the developmental origins of cardiometabolic disease following exposure to maternal obesity and GDM. In addition, this review addresses the potential mechanisms involved in these sex differences. In many studies, sex is ignored as an important variable in disease development; however, the results presented in this review highlight important differences between sexes in the developmental programming of biological responses to exposures during the fetal stage. This knowledge will ultimately help in the development of effective therapeutic strategies for the treatment of cardiometabolic diseases that exhibit sexual dimorphism.
C1 [Talbot, Charlotte Pauline Joelle; Dolinsky, Vernon Wayne] Univ Manitoba, Dept Pharmacol & Therapeut, Childrens Hosp Res Inst Manitoba, Winnipeg, MB R3E 3P4, Canada.
   [Talbot, Charlotte Pauline Joelle; Dolinsky, Vernon Wayne] Univ Manitoba, Diabet Res Envisioned & Accomplished Manitoba Dre, Childrens Hosp Res Inst Manitoba, Winnipeg, MB R3E 3P4, Canada.
   [Talbot, Charlotte Pauline Joelle; Dolinsky, Vernon Wayne] Univ Manitoba, Manitoba Dev Origins Chron Dis Children Network D, Winnipeg, MB R3E 3P4, Canada.
C3 University of Manitoba; Children's Hospital Research Institute of
   Manitoba; University of Manitoba; Children's Hospital Research Institute
   of Manitoba; University of Manitoba
RP Dolinsky, VW (corresponding author), Univ Manitoba, Dept Pharmacol & Therapeut, Childrens Hosp Res Inst Manitoba, Winnipeg, MB R3E 3P4, Canada.; Dolinsky, VW (corresponding author), Univ Manitoba, Diabet Res Envisioned & Accomplished Manitoba Dre, Childrens Hosp Res Inst Manitoba, Winnipeg, MB R3E 3P4, Canada.; Dolinsky, VW (corresponding author), Univ Manitoba, Manitoba Dev Origins Chron Dis Children Network D, Winnipeg, MB R3E 3P4, Canada.
EM vdolinsky@chrim.ca
FU Environments, Genes and Chronic Disease Canadian Institutes for Health
   Research Team Grant [144626]
FX V.W.D. is the Allen Rouse-Manitoba Medical Services Foundation Basic
   Scientist. This research was supported by Environments, Genes and
   Chronic Disease Canadian Institutes for Health Research Team Grant No.
   144626.
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NR 84
TC 22
Z9 22
U1 0
U2 12
PU CANADIAN SCIENCE PUBLISHING
PI OTTAWA
PA 65 AURIGA DR, SUITE 203, OTTAWA, ON K2E 7W6, CANADA
SN 1715-5312
EI 1715-5320
J9 APPL PHYSIOL NUTR ME
JI Appl. Physiol. Nutr. Metab.
PD JUL
PY 2019
VL 44
IS 7
BP 687
EP 695
DI 10.1139/apnm-2018-0667
PG 9
WC Nutrition & Dietetics; Physiology; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics; Physiology; Sport Sciences
GA IF1TX
UT WOS:000472862000001
PM 30500266
DA 2025-06-11
ER

PT J
AU B'chir, W
   Dufour, CR
   Ouellet, C
   Yan, M
   Tam, IS
   Andrzejewski, S
   Xia, H
   Nabata, K
   St-Pierre, J
   Giguère, V
AF B'chir, Wafa
   Dufour, Catherine R.
   Ouellet, Carlo
   Yan, Ming
   Tam, Ingrid S.
   Andrzejewski, Sylvia
   Xia, Hui
   Nabata, Kylie
   St-Pierre, Julie
   Giguere, Vincent
TI Divergent Role of Estrogen-Related Receptor α in Lipid- and
   Fasting-Induced Hepatic Steatosis in Mice
SO ENDOCRINOLOGY
LA English
DT Article
ID GROWTH-FACTOR 21; PPAR-ALPHA; METABOLIC HOMEOSTASIS; OXIDATIVE STRESS;
   ADIPOSE-TISSUE; FATTY LIVER; ERR-ALPHA; FIBROBLAST-GROWTH-FACTOR-21;
   REGULATOR; PROTEIN
AB Given the increasing prevalence of obesity and the metabolic syndrome, identification of intrinsic molecular programs responsible for ensuring fuel homeostasis and preventing metabolic disease is needed. We investigated whether the orphan nuclear receptor estrogen-related receptor alpha (ERR alpha), a major regulator of energy metabolism, plays a role in lipid homeostasis and the development of nonalcoholic fatty liver disease (NAFLD) in response to chronic high-fat diet (HFD) consumption and long-term fasting. Systemic ablation of ERR alpha in mice demonstrated clear beneficial effects for loss of ERR alpha function in protection from HFD-provoked body weight gain manifested not only from a reduction in white adipose tissue stores but also from an impediment in intrahepatic lipid accumulation. The prevention of HFD-induced NAFLD in ERR alpha-null mice was underscored by transcriptional repression of de novo lipogenesis, which was upregulated in wild-type mice, a known contributing factor to lipid-stimulated hepatic steatosis. Surprisingly, given these findings, ERR alpha deficiency had no significant impact on the degree of fasting-induced NAFLD, involving the mobilization of adipocyte triglyceride (TG) stores into the liver. However, the presence of ERR alpha was essential for acute refeeding-mediated reversal of fasting-induced hepatic TG accretion, underpinned by impaired downregulation of adipose TG lipolysis and reduced hepatic mitochondrial oxidative activity. Taken together, the regulation of lipid handling by ERR alpha depended on the nutritional state, suggesting that negative modulation of ERR alpha activity could be envisaged to prevent lipid-induced NAFLD, whereas inducing its activity would be useful to treat and reverse the instilled disease.
C1 [B'chir, Wafa; Dufour, Catherine R.; Ouellet, Carlo; Yan, Ming; Tam, Ingrid S.; Andrzejewski, Sylvia; Xia, Hui; St-Pierre, Julie; Giguere, Vincent] McGill Univ, Goodman Canc Res Ctr, Montreal, PQ H3A 1A3, Canada.
   [Andrzejewski, Sylvia; Xia, Hui; Nabata, Kylie; St-Pierre, Julie; Giguere, Vincent] McGill Univ, Dept Biochem, Montreal, PQ H3G 1Y6, Canada.
   [Giguere, Vincent] McGill Univ, Dept Med, Montreal, PQ H3G 1Y6, Canada.
   [Giguere, Vincent] McGill Univ, Dept Oncol, Montreal, PQ H3G 1Y6, Canada.
   [St-Pierre, Julie] Univ Ottawa, Fac Med, Dept Biochem Microbiol & Immunol, Ottawa Inst Syst Biol, Ottawa, ON K1H 8M5, Canada.
C3 McGill University; McGill University; McGill University; McGill
   University; University of Ottawa
RP Giguère, V (corresponding author), Goodman Canc Res Ctr, McIntyre Bldg,Suite 710A,1160 Pine Ave West, Montreal, PQ H3A 1A3, Canada.
EM vincent.giguere@mcgill.ca
RI St-Pierre, Julie/AGB-3651-2022; Yan, Ming/A-2355-2010
OI St-Pierre, Julie/0000-0002-2815-7099; Xia, Hui/0000-0002-3603-1920;
   Giguere, Vincent/0000-0001-9567-3694; Dufour, Catherine
   Rosa/0000-0001-7324-3458
FU Canadian Institutes for Health Research [MOP-64275, MOP-125885]; Canada
   Foundation for Innovation [21875]; Dr. John R. and Clara M. Fraser
   Memorial Trust; Terry Fox Foundation Oncometabolism Team Grant
   [TFRI-1048]; McGill Integrated Cancer Research Training Program
FX This study was supported by the Canadian Institutes for Health Research
   (Grants MOP-64275 and MOP-125885 to V.G.). The metabolomics Core
   Facility is supported by the Canada Foundation for Innovation (project
   no. 21875), the Dr. John R. and Clara M. Fraser Memorial Trust, and the
   Terry Fox Foundation Oncometabolism Team Grant (TFRI-1048). W.B. was
   supported in part by the McGill Integrated Cancer Research Training
   Program.
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NR 30
TC 33
Z9 36
U1 0
U2 19
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0013-7227
EI 1945-7170
J9 ENDOCRINOLOGY
JI Endocrinology
PD MAY
PY 2018
VL 159
IS 5
BP 2153
EP 2164
DI 10.1210/en.2018-00115
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA GG4RY
UT WOS:000432685100022
PM 29635284
OA Bronze
DA 2025-06-11
ER

PT J
AU Li, RR
   Ou, JJ
   Li, L
   Yang, Y
   Zhao, JP
   Wu, RR
AF Li, Ranran
   Ou, Jianjun
   Li, Li
   Yang, Ye
   Zhao, Jingping
   Wu, Renrong
TI The Wnt Signaling Pathway Effector TCF7L2 Mediates Olanzapine-Induced
   Weight Gain and Insulin Resistance
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Article
DE olanzapine; Wnt signaling pathway; atypical antipsychotics; TCF7L2;
   weight gain; insulin resistance
ID DRUG-NAIVE PATIENTS; VISCERAL FAT DISTRIBUTION; MIDDLE-AGED MEN;
   ATYPICAL ANTIPSYCHOTICS; METABOLIC SYNDROME; CARDIOVASCULAR-DISEASE;
   GLUCOSE-INTOLERANCE; OXIDATIVE STRESS; TREATED PATIENTS; BODY-WEIGHT
AB Olanzapine is a widely used atypical antipsychotic medication for treatment of schizophrenia and is often associated with serious metabolic abnormalities including weight gain and impaired glucose tolerance. These metabolic side effects are severe clinical problems but the underpinning mechanism remains poorly understood. Recently, growing evidence suggests that Wnt signaling pathway has a critical role in the pathogenesis of schizophrenia and molecular cascades of antipsychotics action, of which Wnt signaling pathway key effector TCF7L2 is strongly associated with glucose homeostasis. In this study, we aim to explore the characteristics of metabolic disturbance induced by olanzapine and to elucidate the role of TCF7L2 in this process. C57BL/6 mice were subject to olanzapine (4 mg/kg/day), or olanzapine plus metformin (150 mg/kg/day), or saline, respectively, for 8 weeks. Metabolic indices and TCF7L2 expression levels in liver, skeletal muscle, adipose, and pancreatic tissues were closely monitored. Olanzapine challenge induced remarkably increased body weight, fasting insulin, homeostasis model assessment-insulin resistance index, and TCF7L2 protein expression in liver, skeletal muscle, and adipose tissues. Notably, these effects could be effectively ameliorated by metformin. In addition, we found that olanzapine-induced body weight gain and insulin resistance actively influence the expression of TCF7L2 in liver and skeletal muscle, and elevated level of insulin determines the increased expression of TCF7L2 in adipose tissue. Our results demonstrate that TCF7L2 participates in olanzapine-induced metabolic disturbance, which presents a novel mechanism for olanzapine-induced metabolic disturbance and a potential therapeutic target to prevent the associated metabolic side effects.
C1 [Li, Ranran; Ou, Jianjun; Li, Li; Yang, Ye; Zhao, Jingping; Wu, Renrong] Cent S Univ, Xiangya Hosp 2, Dept Psychiat, Changsha, Hunan, Peoples R China.
   [Wu, Renrong] Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai, Peoples R China.
C3 Central South University; Chinese Academy of Sciences
RP Wu, RR (corresponding author), Cent S Univ, Xiangya Hosp 2, Dept Psychiat, Changsha, Hunan, Peoples R China.; Wu, RR (corresponding author), Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai, Peoples R China.
EM wurenrong@csu.edu.cn
FU National Key Research and Development Program of China [2016YFC1306900];
   National Natural Science Foundation of China [81371481, 81622018]
FX The research was supported by grant 2016YFC1306900 from the National Key
   Research and Development Program of China and the National Natural
   Science Foundation of China (Grant Nos. 81371481 and 81622018).
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NR 89
TC 21
Z9 25
U1 1
U2 28
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD APR 16
PY 2018
VL 9
AR 379
DI 10.3389/fphar.2018.00379
PG 13
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Pharmacology & Pharmacy
GA GC9DW
UT WOS:000430098700001
PM 29713286
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Capel, F
   Geloen, A
   Vaysse, C
   Pineau, G
   Demaison, L
   Chardigny, JM
   Michalski, MC
   Malpuech-Brugère, C
AF Capel, Frederic
   Geloen, Alain
   Vaysse, Carole
   Pineau, Gaelle
   Demaison, Luc
   Chardigny, Jean-Michel
   Michalski, Marie-Caroline
   Malpuech-Brugere, Corinne
TI Rapeseed oil fortified with micronutrients can reduce glucose
   intolerance during a high fat challenge in rats
SO NUTRITION & METABOLISM
LA English
DT Article
DE Fatty acids; Rapeseed oil; Micronutrients; Metabolic syndrome; Obesity
ID OXIDATIVE STRESS; INSULIN-RESISTANCE; DIETARY-FAT; VITAMIN-E; ACIDS;
   OBESITY; INFLAMMATION; METABOLISM; EXPRESSION; PREVENTION
AB Background: Better choices of dietary lipid sources and substitution of refined by fortified oils could reduce the intake of saturated fatty acids (FA) and increase the intake of omega 3 FA concomitantly to healthy bioactive compounds.
   Methods: The development of obesity and metabolic disturbances was explored in rats fed during 11 weeks with a high fat diet (HFD) in which the amount of saturated and polyunsaturated FA was respectively reduced and increased, using rapeseed oil as lipid source. This oil was used in a refined form (R) or fortified (10 fold increase in concentration) with endogenous micronutrients (coenzyme Q10 + tocopherol only (RF) only and also with canolol (RFC)). The effect of substituting palm by rapeseed oil was analysed using a student t test, oil fortification was analysed using ANOVA statistical test.
   Results: Despite a similar weight gain, diets R, RF and RFC improved glucose tolerance (+ 10%) of the rats compared to a standard HFD with palm and sunflower oils as lipid source. Plasma glucose was lowered in RF and RFC groups (- 15 and 23% respectively), although triacylglycerol level was only reduced in group RFC (-33%) compared to R. The fortification with canolol promoted the activation of Akt and AMP-activated protein kinase (AMPK) in skeletal muscle and subcutaneous adipose tissue respectively. Canolol supplementation also led to reduce p38 MAPK activation in skeletal muscle.
   Conclusions: This study suggests that the presence of endogenous micronutrients in rapeseed oil promotes cellular adaptations to reverse glucose intolerance and improve the metabolism of insulin sensitive tissues.
C1 [Capel, Frederic; Demaison, Luc; Chardigny, Jean-Michel; Malpuech-Brugere, Corinne] Univ Clermont Auvergne, CRNH Auvergne, INRA, UNH, 58 Rue Montalembert,BP 321, F-63000 Clermont Ferrand, France.
   [Geloen, Alain; Pineau, Gaelle; Michalski, Marie-Caroline] Univ Claude Bernard Lyon 1, Univ Lyon, INSERM, INSA Lyon,Lab CarMeN,INRA,UMR1397,U1060,IMBL, F-69621 Villeurbanne, France.
   [Vaysse, Carole] Univ Bordeaux, ITERG ENMS, Rue Leo Saignat, F-33076 Bordeaux, France.
   [Chardigny, Jean-Michel] INRA Bourgogne Franche Comte Batiment Magnen, Ctr Rech, 17 Rue Sully,BP 86510, F-21065 Dijon, France.
C3 INRAE; Universite Clermont Auvergne (UCA); Universite Claude Bernard
   Lyon 1; Institut National de la Sante et de la Recherche Medicale
   (Inserm); INRAE; Institut National des Sciences Appliquees de Lyon -
   INSA Lyon; Universite de Bordeaux; INRAE
RP Capel, F (corresponding author), Univ Clermont Auvergne, CRNH Auvergne, INRA, UNH, 58 Rue Montalembert,BP 321, F-63000 Clermont Ferrand, France.
EM frederic.capel@inra.fr
RI GELOEN, Alain/D-6725-2011; Capel, Frederic/AAW-8838-2020;
   Malpuech-Brugere, Corinne/D-6848-2017; MICHALSKI,
   Marie-Caroline/Q-4613-2017
OI Capel, Frederic/0000-0002-0133-0277; Lab, Carmen/0000-0002-5935-3236;
   Malpuech-Brugere, Corinne/0000-0001-9286-4647; Carmen,
   Team1/0000-0003-4234-1746; MICHALSKI,
   Marie-Caroline/0000-0002-2956-901X; GELOEN, Alain/0000-0001-7921-1254
FU French Government [ANR-001-01]; SAS PIVERT
FX This work was performed, in partnership with the SAS PIVERT, within the
   frame of the French Institute for the Energy Transition (Institut pour
   la Transition Energetique (ITE) P.I.V.E.R.T. (www.institut-pivert.com)
   selected as an Investment for the Future ("Investissements d'Avenir").
   This work was supported, as part of the Investments for the Future, by
   the French Government under the reference ANR-001-01.
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NR 37
TC 9
Z9 9
U1 0
U2 13
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1743-7075
J9 NUTR METAB
JI Nutr. Metab.
PD MAR 20
PY 2018
VL 15
AR 22
DI 10.1186/s12986-018-0259-x
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA FZ8UX
UT WOS:000427887000001
PM 29568317
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Tinkov, AA
   Gatiatulina, ER
   Popova, EV
   Polyakova, VS
   Skalnaya, AA
   Agletdinov, EF
   Nikonorov, AA
   Skalny, AV
AF Tinkov, Alexey A.
   Gatiatulina, Eugenia R.
   Popova, Elizaveta V.
   Polyakova, Valentina S.
   Skalnaya, Anastasia A.
   Agletdinov, Eduard F.
   Nikonorov, Alexandr A.
   Skalny, Anatoly V.
TI Early High-Fat Feeding Induces Alteration of Trace Element Content in
   Tissues of Juvenile Male Wistar Rats
SO BIOLOGICAL TRACE ELEMENT RESEARCH
LA English
DT Article
DE Adiposity; Chromium; Vanadium; Adipose tissue; Obesity
ID INCREASED OXIDATIVE STRESS; INSULIN-RESISTANCE; CHILDHOOD OBESITY;
   METABOLIC SYNDROME; COPPER; ZINC; DIET; IRON; DEFICIENCY; SELENIUM
AB The primary objective of the current study was to assess the influence of early high-fat feeding on tissue trace element content in young male Wistar rats. Twenty weanling male Wistar rats were divided into two groups fed standard (STD) or high-fat diet (HFD) containing 10 and 31.6 % of total calories from fat, respectively, for 1 month. Serum lipid spectrum, apolipoproteins, glucose, insulin, adiponectin, and leptin levels were assessed. The level of trace elements was estimated using inductively coupled plasma mass spectrometry. High-fat feeding significantly increased epidydimal (EDAT) and retroperitoneal adipose tissue (RPAT), as well as total adipose tissue mass by 34, 103, and 59 %, respectively. Serum leptin levels in HFD animals were twofold higher than those in the control rats. No significant difference in serum lipid spectrum, apolipoproteins, glucose, adiponectin, and insulin was detected between the groups. HFD significantly altered tissue trace element content. In particular, HFD-fed animals were characterized by significantly lower levels of Cu, I, Mn, Se, and Zn in the liver; Cr, V, Co, Cu, Fe, and I content of EDAT; Co, Cu, I, Cr, V, Fe, and Zn concentration in RPAT samples. At the same time, only serum Cu was significantly depressed in HFD-fed animals as compared to the control ones. Hair Co, Mn, Si, and V levels were significantly increased in comparison to the control values, whereas Se and I content was decreased. HFD feeding induced excessive adiposity and altered tissue trace element content in rats without insulin resistance, adiponectin deficiency, and proatherogenic state. Hypothetically, trace element disbalance may precede obesity-associated metabolic disturbances.
C1 [Tinkov, Alexey A.; Gatiatulina, Eugenia R.; Popova, Elizaveta V.; Nikonorov, Alexandr A.] Orenburg State Med Univ, Dept Biochem, Sovetskaya St 6, Orenburg 460000, Russia.
   [Tinkov, Alexey A.; Nikonorov, Alexandr A.; Skalny, Anatoly V.] Orenburg State Univ, Inst Bioelementol, Russian Satellite Ctr Trace Element, Inst UNESCO, Pobedy Ave 13, Orenburg 460352, Russia.
   [Tinkov, Alexey A.; Skalny, Anatoly V.] Yaroslavl State Univ, Lab Biotechnol & Appl Bioelementol, Sovetskaya St 14, Yaroslavl 150000, Russia.
   [Polyakova, Valentina S.] Orenburg State Med Univ, Dept Pathol Anat, Sovetskaya St 6, Orenburg 460000, Russia.
   [Skalnaya, Anastasia A.] Lomonosov Moscow State Univ, Fac Fundamental Med, Lomonosovsky Prospekt 31-5, Moscow 117192, Russia.
   [Agletdinov, Eduard F.] Bashkir State Med Univ, Cent Res Lab, Zaki Validi St 64-2, Ufa 450057, Russia.
   [Skalny, Anatoly V.] All Russian Res Inst Med & Aromat Plants VILAR, Grina St 7, Moscow 117216, Russia.
C3 Orenburg State University; Yaroslavl State University; Lomonosov Moscow
   State University; Bashkir State Medical University; All-Russian Research
   Institute of Medicinal & Aromatic Plants
RP Tinkov, AA (corresponding author), Orenburg State Med Univ, Dept Biochem, Sovetskaya St 6, Orenburg 460000, Russia.; Tinkov, AA (corresponding author), Orenburg State Univ, Inst Bioelementol, Russian Satellite Ctr Trace Element, Inst UNESCO, Pobedy Ave 13, Orenburg 460352, Russia.; Tinkov, AA (corresponding author), Yaroslavl State Univ, Lab Biotechnol & Appl Bioelementol, Sovetskaya St 14, Yaroslavl 150000, Russia.
EM tinkov.a.a@gmail.com
RI Skalny, Anatoly/J-3953-2019; Nikonorova, Eugenia/AAQ-5445-2020;
   Polyakova, Valentina/AAE-7314-2019; Tinkov, Alexey/H-5842-2016
OI Tinkov, Alexey/0000-0003-0348-6192; Nikonorova,
   Eugenia/0000-0002-6360-2194; Skalny, Anatoly/0000-0001-7838-1366;
   Polyakova, Valentina/0000-0002-2930-2673; Nikonorov,
   Alexandr/0000-0001-7214-8176; Popova, Elizabeth/0000-0001-6703-4756
CR [Anonymous], THE END OF THE OBESI
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NR 59
TC 17
Z9 17
U1 0
U2 26
PU HUMANA PRESS INC
PI TOTOWA
PA 999 RIVERVIEW DRIVE SUITE 208, TOTOWA, NJ 07512 USA
SN 0163-4984
EI 1559-0720
J9 BIOL TRACE ELEM RES
JI Biol. Trace Elem. Res.
PD FEB
PY 2017
VL 175
IS 2
BP 367
EP 374
DI 10.1007/s12011-016-0777-1
PG 8
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA EI2RS
UT WOS:000392336200016
PM 27311579
DA 2025-06-11
ER

PT J
AU Winkler, M
   Schuchard, J
   Stölting, I
   Vogt, FM
   Barkhausen, J
   Thorns, C
   Bader, M
   Raasch, W
AF Winkler, Martina
   Schuchard, Johanna
   Stoelting, Ines
   Vogt, Florian M.
   Barkhausen, Joerg
   Thorns, Christoph
   Bader, Michael
   Raasch, Walter
TI The brain renin-angiotensin system plays a crucial role in regulating
   body weight in diet-induced obesity in rats
SO BRITISH JOURNAL OF PHARMACOLOGY
LA English
DT Article
ID PITUITARY-ADRENAL AXIS; BLOOD-PRESSURE; TRANSGENIC RATS; ADIPOSE-TISSUE;
   AT(1) RECEPTOR; ZUCKER RATS; STRESS SENSITIVITY; METABOLIC SYNDROME;
   LEPTIN RESISTANCE; PANCREATIC-ISLETS
AB BACKGROUND AND PURPOSE
   Reduced weight gain after treatment with AT(1) receptor antagonists may involve a brain-related mechanism. Here, we investigated the role of the brain renin-angiotensin system on weight regulation and food behaviour, with or without additional treatment with telmisartan.
   METHODS
   Transgenic rats with a brain-specific deficiency in angiotensinogen (TGR(ASrAOGEN)) and the corresponding wild-type, Sprague Dawley (SD) rats were fed (3 months) with a high-calorie cafeteria diet (CD) or standard chow. SD and TGR(ASrAOGEN) rats on the CD diet were also treated with telmisartan (8 mg.kg(-1).d(-1), 3 months).
   RESULTS
   Compared with SD rats, TGR(ASrAOGEN) rats (i) had lower weights during chow feeding, (ii) did not become obese during CD feeding, (iii) had normal baseline leptin plasma concentrations independent of the feeding regimen, whereas plasma leptin of SD rats was increased due to CD, (iv) showed a reduced energy intake, (v) had a higher, strain-dependent energy expenditure, which is additionally enhanced during CD feeding, (vi) had enhanced mRNA levels of pro-opiomelanocortin and (vii) showed improved glucose control. Weight gain and energy intake in rats fed the CD diet were markedly reduced by telmisartan in SD rats but only to a minor extent in TGR(ASrAOGEN) rats.
   CONCLUSIONS
   The brain renin-angiotensin system affects body weight regulation, feeding behaviour and metabolic disorders. When angiotensin II levels are low in brain, rats are protected from developing diet-induced obesity and obesity-related metabolic impairments. We further suggest that telmisartan at least partly lowers body weight via a CNS-driven mechanism.
C1 [Winkler, Martina; Schuchard, Johanna; Stoelting, Ines; Raasch, Walter] Univ Lubeck, Inst Expt & Clin Pharmacol & Toxicol, Ratzeburger Allee 160, D-23538 Lubeck, Germany.
   [Schuchard, Johanna; Raasch, Walter] DZHK German Ctr Cardiovasc Res, Partner Site Hamburg Kiel Lubeck, Lubeck, Germany.
   [Vogt, Florian M.; Barkhausen, Joerg] Univ Lubeck, Dept Radiol & Nucl Med, D-23538 Lubeck, Germany.
   [Thorns, Christoph] Univ Clin Schleswig Holstein, Dept Pathol, Campus Lubeck, Lubeck, Germany.
   [Bader, Michael] Max Delbruck Ctr Mol Med MDC, Berlin, Germany.
   [Bader, Michael] DZHK German Ctr Cardiovasc Res, Partner Site Berlin, Berlin, Germany.
   [Bader, Michael] Univ Lubeck, Inst Biol, Ctr Struct & Cell Biol Med, D-23538 Lubeck, Germany.
   [Bader, Michael] Charite, D-13353 Berlin, Germany.
   [Raasch, Walter] CBBM, Lubeck, Germany.
C3 University of Lubeck; German Centre for Cardiovascular Research;
   University of Lubeck; University of Kiel; Schleswig Holstein University
   Hospital; Helmholtz Association; Max Delbruck Center for Molecular
   Medicine; German Centre for Cardiovascular Research; University of
   Lubeck; Berlin Institute of Health; Free University of Berlin; Humboldt
   University of Berlin; Charite Universitatsmedizin Berlin
RP Raasch, W (corresponding author), Univ Lubeck, Inst Expt & Clin Pharmacol & Toxicol, Ratzeburger Allee 160, D-23538 Lubeck, Germany.
EM walter.raasch@pharma.uni-luebeck.de
RI Bader, Michael/K-2124-2013; Vogt, Florian/C-1705-2012; Raasch,
   Walter/AAR-1165-2020; Barkhausen, Joerg/E-3921-2010
OI Bader, Michael/0000-0003-4780-4164
FU Konrad Adenauer Stiftung (Germany); Boehringer Ingelheim
   Pharmaceuticals, Inc. (Ingelheim, Germany)
FX This study was supported by a grant from the Konrad Adenauer Stiftung
   (Germany). W. R. received telmisartan from Boehringer Ingelheim
   Pharmaceuticals, Inc. (Ingelheim, Germany).
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NR 72
TC 24
Z9 27
U1 0
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0007-1188
EI 1476-5381
J9 BRIT J PHARMACOL
JI Br. J. Pharmacol.
PD MAY
PY 2016
VL 173
IS 10
SI SI
BP 1602
EP 1617
DI 10.1111/bph.13461
PG 16
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA DK5QX
UT WOS:000374976000004
PM 26892671
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Paiva, FM
   Vianna, LC
   Fernandes, IA
   Nóbrega, AC
   Lima, RM
AF Paiva, F. M.
   Vianna, L. C.
   Fernandes, I. A.
   Nobrega, A. C.
   Lima, R. M.
TI Effects of disturbed blood flow during exercise on endothelial function:
   a time course analysis
SO BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
LA English
DT Article
DE Blood flow restriction; Vascular function; Flow-mediated dilation; Shear
   stress
ID CORONARY-ARTERY-DISEASE; MEDIATED DILATION; BRACHIAL-ARTERY; SHEAR RATE;
   PHYSICAL-ACTIVITY; ULTRASOUND ASSESSMENT; METABOLIC SYNDROME; VASCULAR
   FUNCTION; TRAINED MEN; HUMANS
AB This study aimed to examine the time course of endothelial function after a single handgrip exercise session combined with blood flow restriction in healthy young men. Nine participants (28 +/- 5.8 years) completed a single session of bilateral dynamic handgrip exercise (20 min with 60% of the maximum voluntary contraction). To induce blood flow restriction, a cuff was placed 2 cm below the antecubital fossa in the experimental arm. This cuff was inflated to 80 mmHg before initiation of exercise and maintained through the duration of the protocol. The experimental arm and control arm were randomly selected for all subjects. Brachial artery flow-mediated dilation (FMD) and blood flow velocity profiles were assessed using Doppler ultrasonography before initiation of the exercise, and at 15 and 60 min after its cessation. Blood flow velocity profiles were also assessed during exercise. There was a significant increase in FMD 15 min after exercise in the control arm compared with before exercise (64.09%+/- 16.59%, P=0.001), but there was no change in the experimental arm (-12.48%+/- 12.64%, P=0.252). FMD values at 15 min post-exercise were significantly higher for the control arm in comparison to the experimental arm (P=0.004). FMD returned to near baseline values at 60 min after exercise, with no significant difference between arms (P=0.424). A single handgrip exercise bout provoked an acute increase in FMD 15 min after exercise, returning to near baseline values at 60 min. This response was blunted by the addition of an inflated pneumatic cuff to the exercising arm.
C1 [Paiva, F. M.; Vianna, L. C.; Lima, R. M.] Univ Brasilia, Fac Educ Fis, Brasilia, DF, Brazil.
   [Fernandes, I. A.; Nobrega, A. C.] Univ Fed Fluminense, Lab Ciencias Exercicio, Niteroi, RJ, Brazil.
C3 Universidade de Brasilia; Universidade Federal Fluminense
RP Vianna, LC (corresponding author), Univ Brasilia, Fac Educ Fis, Brasilia, DF, Brazil.
EM lcvianna@unb.br
RI da Nobrega, Antonio/O-5107-2019; LIMA, RICARDO/U-6511-2019; Vianna,
   Lauro/A-8188-2008; Fernandes, Igor Alexandre/G-9589-2012
OI Fernandes, Igor Alexandre/0000-0002-0206-6316; Vianna,
   Lauro/0000-0002-5747-0295; LIMA, RICARDO/0000-0001-8603-7514; Fernandes,
   Igor Alexandre/0000-0003-3873-2656
FU Brazilian National Council for Scientific and Technological Development
   (CNPq) [87584/2013-9]
FX This study was financially supported by the Brazilian National Council
   for Scientific and Technological Development (CNPq #87584/2013-9).
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NR 39
TC 16
Z9 17
U1 0
U2 10
PU ASSOC BRAS DIVULG CIENTIFICA
PI SAO PAULO
PA FACULDADE MEDICINA, SALA 21, 14049 RIBEIRAO PRETO, SAO PAULO, 00, BRAZIL
SN 0100-879X
EI 1678-4510
J9 BRAZ J MED BIOL RES
JI Brazilian J. Med. Biol. Res.
PY 2016
VL 49
IS 4
AR e5100
DI 10.1590/1414-431X20155100
PG 9
WC Biology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics; Research & Experimental
   Medicine
GA DG0DQ
UT WOS:000371733500005
PM 26909789
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Lakshman, R
   Shah, R
   Reyes-Gordillo, K
   Varatharajalu, R
AF Lakshman, Raj
   Shah, Ruchi
   Reyes-Gordillo, Karina
   Varatharajalu, Ravi
TI Synergy between NAFLD and AFLD and potential biomarkers
SO CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY
LA English
DT Review
ID FATTY LIVER-DISEASE; TUMOR-NECROSIS-FACTOR; FACTOR-KAPPA-B;
   INSULIN-RESISTANCE; TNF-ALPHA; NONALCOHOLIC STEATOHEPATITIS;
   ENDOPLASMIC-RETICULUM; TRANSCRIPTION FACTOR; MECHANISMS; FIBROSIS
AB Fatty liver (hepatosteatosis) is the earliest abnormality in the pathogenesis of nonalcoholic fatty liver disease (NAFLD) and alcoholic fatty liver disease (AFLD) due either to metabolic risk factors associated with insulin resistance and/or metabolic syndrome in the absence of alcohol consumption or to chronic alcohol abuse. When unchecked, both NAFLD and AFLD lead to steatohepatitis, fibrosis, cirrhosis, hepatocellular carcinoma (HCC) and eventual death. A number of common mechanisms contribute to the above various stages of hepatocyte injury, including lipotoxicity, endotoxin release, oxidative and ER stress leading to increased pro-inflammatory cytokines that stimulate hepatic fibrogenesis and cirrhosis by activating the quiescent hepatic stellate cells (HSC) into myofibroblasts. Significantly, patients with either NAFLD or AFLD respond favorably to early treatment modalities to reduce hepatic fat accumulation and consequent increased inflammatory signalling and activation of hepatic stellate cells. Although the pathogenic pathways associated with NAFLD and AFLD are seemingly similar, differentiation of the molecular mechanism/s of the pathogenesis of these liver diseases is critical in identifying the unique molecular signatures, especially in the early diagnosis of NAFLD and AFLD. Current clinical practice requires the invasive biopsy procedure for the conclusive diagnosis of NAFLD and AFLD. Micro RNAs (miRNAs) are similar to 22 nucleotide non-coding sequences that bind to the 3'-untranslated region of target transcripts and regulate gene expression by degradation of target mRNAs or inhibition of translation. Emerging studies may prove to establish miRNAs as excellent non-invasive tools for the early diagnosis of various stages of liver diseases. Published by Elsevier Masson SAS.
C1 [Lakshman, Raj] VA Med Ctr, Lipid Res Lab, 50 Irving St, Washington, DC 20422 USA.
   George Washington Univ, Dept Biochem & Mol Med, Washington, DC 20422 USA.
C3 George Washington University
RP Lakshman, R (corresponding author), VA Med Ctr, Lipid Res Lab, 50 Irving St, Washington, DC 20422 USA.
EM raj.lakshman@va.gov
RI Shah, Ruchi/I-6386-2019
OI Shah, Ruchi/0000-0002-9533-1747
FU NIH [RO1 AA020720, RO1 AA009231, R21 AA022205]
FX This work is supported by the NIH grants RO1 AA020720 (MRL), RO1
   AA009231 (MRL), and R21 AA022205 (MRL).
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NR 50
TC 24
Z9 25
U1 0
U2 12
PU ELSEVIER MASSON, CORPORATION OFFICE
PI PARIS
PA 65 CAMILLE DESMOULINS CS50083 ISSY-LES-MOULINEAUX, 92442 PARIS, FRANCE
SN 2210-7401
EI 2210-741X
J9 CLIN RES HEPATOL GAS
JI Clin. Res. Hepatol. Gastroenterol.
PD SEP
PY 2015
VL 39
SU 1
BP S29
EP S34
DI 10.1016/j.clinre.2015.05.007
PG 6
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA DI0HJ
UT WOS:000373176000007
PM 26189985
DA 2025-06-11
ER

PT J
AU Filis, P
   Nagrath, N
   Fraser, M
   Hay, DC
   Iredale, JP
   O'Shaughnessy, P
   Fowler, PA
AF Filis, Panagiotis
   Nagrath, Nalin
   Fraser, Margaret
   Hay, David C.
   Iredale, John P.
   O'Shaughnessy, Peter
   Fowler, Paul A.
TI Maternal Smoking Dysregulates Protein Expression in Second Trimester
   Human Fetal Livers in a Sex-Specific Manner
SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Article
ID IN-UTERO EXPOSURE; CIGARETTE-SMOKE; ALPHA-FETOPROTEIN; ENZYME
   EXPRESSION; PREGNANCY; ERP57; PHOSPHORYLATION; ASSOCIATION; HOMEOSTASIS;
   METABOLISM
AB Context: Maternal smoking during pregnancy has adverse effects on the offspring (eg, increased likelihood of metabolic syndrome and infertility), which may involve alterations in fetal liver function.
   Objective: Our aim was to analyze, for the first time, the human fetal liver proteome to identify pathways affected by maternal smoking.
   Design: Fetal liver proteins extracted from elective second trimester pregnancy terminations (12-16 weeks of gestation) were divided in four balanced groups based on sex and maternal smoking.
   Setting and Participants: Livers were collected from 24 morphologically normal fetuses undergoing termination for nonmedical reasons and analyzed at the Universities of Aberdeen and Glasgow.
   Main Outcome Measures: Protein extracts were resolved by 2D-PAGE and analyzed with SameSpots software. Ingenuity pathway analysis was used to investigate likely roles of dysregulated proteins identified by tandem liquid chromatography/ mass spectroscopy.
   Results: Significant expression differences between one or more groups (fetal sex and/or maternal smoking) were found in 22 protein spots. Maternal smoking affected proteins with roles in post-translational protein processing and secretion (ERP29, PDIA3), stress responses and detoxification (HSP90AA1, HSBP1, ALDH7A1, CAT), and homeostasis (FTL1, ECHS1, GLUD1, AFP, SDHA). Although proteins involved in necrosis and cancer development were affected in both sexes, pathways affecting cellular homeostasis, inflammation, proliferation, and apoptosis were affected in males and pathways affecting glucose metabolism were affected in females.
   Conclusions: The fetal liver exhibits marked sex differences at the protein level, and these are disturbed by maternal smoking. The foundations for smoke-induced post-natal diseases are likely to be due to sex-specific effects on diverse pathways.
C1 [Filis, Panagiotis; Nagrath, Nalin; Fraser, Margaret; Fowler, Paul A.] Univ Aberdeen, Div Appl Med, Inst Med Sci, Aberdeen AB25 2ZD, Scotland.
   [O'Shaughnessy, Peter] Univ Glasgow, Coll Med Vet & Life Sci, Inst Biodivers Anim Hlth & Comparat Med, Glasgow G61 1QH, Lanark, Scotland.
   [Hay, David C.] Univ Edinburgh, Ctr Regenerat Med, MRC, Edinburgh EH16 4SB, Midlothian, Scotland.
   [Iredale, John P.] Univ Edinburgh, Queens Med Res Inst, Ctr Inflammat Res, MRC, Edinburgh EH16 4TJ, Midlothian, Scotland.
C3 University of Aberdeen; University of Glasgow; University of Edinburgh;
   University of Edinburgh
RP Filis, P (corresponding author), Univ Aberdeen, Div Appl Med, Inst Med Sci, Aberdeen AB25 2ZD, Scotland.
EM pfilis@abdn.ac.uk
RI Iredale, John/C-7300-2013; Hay, David/JZD-9418-2024; Fowler,
   Paul/A-5644-2008
OI Iredale, John/0000-0003-2174-5127; Filis,
   Panagiotis/0000-0002-4121-9354; Fowler, Paul/0000-0002-4831-9075
FU Chief Scientist Office (Scottish Executive) [CZG/1/109, CZG/4/742];
   National Health Service Grampian Endowments [08/02]; European
   Community's Seventh Framework Programme (FP7) [212885]; Medical Research
   Council, UK [MR/L010011/1]; MRC [MR/J010766/1, MR/L010011/1, G0600033,
   G0901697] Funding Source: UKRI
FX Support for the study was provided by the Chief Scientist Office
   (Scottish Executive, CZG/1/109, & CZG/4/742), National Health Service
   Grampian Endowments (08/02), the European Community's Seventh Framework
   Programme (FP7/2007-2013) under grant agreement no 212885, and the
   Medical Research Council, UK (MR/L010011/1).
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NR 48
TC 25
Z9 26
U1 0
U2 8
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0021-972X
EI 1945-7197
J9 J CLIN ENDOCR METAB
JI J. Clin. Endocrinol. Metab.
PD JUN
PY 2015
VL 100
IS 6
BP E861
EP E870
DI 10.1210/jc.2014-3941
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA CQ8ET
UT WOS:000360840000005
PM 25803269
OA Green Published, hybrid, Green Submitted
DA 2025-06-11
ER

PT J
AU Javed, F
   Tenenbaum, HC
   Nogueira, G
   Nooh, N
   Correa, FO
   Warnakulasuriya, S
   Dasanayake, AP
   Al-Hezaimi, K
AF Javed, Fawad
   Tenenbaum, Howard C.
   Nogueira-Filho, Getulio
   Nooh, Nasser
   Correa, Fernanda O'Bello
   Warnakulasuriya, Saman
   Dasanayake, Ananda P.
   Al-Hezaimi, Khalid
TI Periodontal Inflammatory Conditions Among Gutka Chewers and Non-chewers
   With and Without Prediabetes
SO JOURNAL OF PERIODONTOLOGY
LA English
DT Article
DE Alveolar bone loss; areca; diabetes mellitus; inflammation; pre-diabetic
   state; tobacco; smokeless
ID PERCEIVED ORAL-HEALTH; ARECA-NUT; OXIDATIVE-STRESS;
   SOCIOECONOMIC-STATUS; METABOLIC SYNDROME; RISK-FACTOR; ARECOLINE;
   EXTRACT; ATTACHMENT; MICE
AB Background: It is known that gutka chewing jeopardizes periodontal health; however, severity of periodontal inflammation in gutka chewers with and without prediabetes remains unknown. The aim of this study is to investigate the association of periodontal inflammatory conditions with gutka chewing and prediabetes.
   Methods: In this cross-sectional study, the effect of gutka use on periodontal health is investigated among 44 individuals with prediabetes and 44 without prediabetes. Demographic information regarding age, sex, duration of prediabetes, and gutka-chewing habits was collected using a questionnaire. Periodontal inflammatory conditions (plaque index [PI], bleeding on probing [BOP], probing depth [PD], marginal bone loss [MBL]) and fasting blood glucose levels (FBGLs) were recorded. Group differences in periodontal inflammatory parameters were tested using univariate and multivariable analyses (alpha <= 5%).
   Results: Periodontal inflammatory parameters (PI, BOP, and PD) were significantly higher in individuals with prediabetes irrespective of gutka-chewing habit (P < 0.05). Odds of periodontal inflammation in individuals with prediabetes were nine times higher than in healthy controls (95% confidence interval [CI] = 3.4 to 23.6). Gutka chewing alone, chewing among individuals with prediabetes, and chewing among healthy controls did not significantly increase the odds of periodontal inflammatory conditions. Individuals with prediabetes were significantly more likely to have periodontal inflammation than individuals without prediabetes even after controlling for sex and gutka chewing (odds ratio = 13.2; 95% CI = 4.3 to 40.7).
   Conclusion: In medically healthy individuals, periodontal inflammatory conditions are worse in gutka chewers compared to non-chewers; in patients with prediabetes, the severity of periodontal inflammation is governed by hyperglycemia when compared to habitual gutka usage.
C1 [Javed, Fawad; Al-Hezaimi, Khalid] King Saud Univ, Engineer Abdullah Bugshan Res Chair Growth Factor, Imaging & Biomech Lab 3D, Coll Appl Med Sci, Riyadh 11545, Saudi Arabia.
   [Javed, Fawad; Al-Hezaimi, Khalid] King Saud Univ, Dept Periodont & Community Dent, Riyadh 11545, Saudi Arabia.
   [Tenenbaum, Howard C.] Univ Toronto, Fac Dent, Dept Periodontol, Toronto, ON, Canada.
   [Nogueira-Filho, Getulio] Univ Toronto, Dept Prevent Dent, Fac Dent, Toronto, ON, Canada.
   [Nooh, Nasser] King Saud Univ, Coll Dent, Dept Oral & Maxillofacial Surg, Riyadh 11545, Saudi Arabia.
   [Correa, Fernanda O'Bello] Univ Fed Pelotas, Sch Dent, Dept Semiol & Clin, Pelotas, Brazil.
   [Warnakulasuriya, Saman] Kings Coll London, Dept Oral Med, London, England.
   [Warnakulasuriya, Saman] World Hlth Org Collaborating Ctr Oral Canc & Prec, London, England.
   [Dasanayake, Ananda P.] NYU, Coll Dent, Dept Epidemiol & Hlth Promot, New York, NY USA.
C3 King Saud University; King Saud University; University of Toronto;
   University of Toronto; King Saud University; Universidade Federal de
   Pelotas; University of London; King's College London; World Health
   Organization; New York University
RP Javed, F (corresponding author), King Saud Univ, Engineer Abdullah Bugshan Res Chair Growth Factor, Imaging & Biomech Lab 3D, Coll Appl Med Sci, POB 60169, Riyadh 11545, Saudi Arabia.
EM fawjav@gmail.com
RI Correa, Fernanda/AAY-8949-2021; , WARNAKULASURIYA/ABB-3793-2020; Javed,
   Fawad/A-6608-2012
OI Warnakulasuriya, Saman/0000-0003-2103-0746; Tenenbaum, Howard
   C/0009-0006-5363-544X; Nogueira, Getulio/0000-0002-3847-5090; Javed,
   Fawad/0000-0002-9253-1989; Correa, Fernanda/0000-0001-9569-4743
FU College of Dentistry Research Center at King Saud University, Saudi
   Arabia; Deanship of Scientific Research at King Saud University, Saudi
   Arabia [NF 2374]
FX The authors would like to thank the College of Dentistry Research Center
   and Deanship of Scientific Research at King Saud University, Saudi
   Arabia for funding this research project (Research project #NF 2374).
   The authors report no conflicts of interest related to this study.
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NR 25
TC 45
Z9 46
U1 0
U2 8
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-3492
EI 1943-3670
J9 J PERIODONTOL
JI J. Periodont.
PD AUG
PY 2013
VL 84
IS 8
BP 1158
EP 1164
DI 10.1902/jop.2012.120390
PG 7
WC Dentistry, Oral Surgery & Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dentistry, Oral Surgery & Medicine
GA 275NW
UT WOS:000328685100014
PM 23088525
DA 2025-06-11
ER

PT J
AU Puri, R
   Duong, M
   Uno, K
   Kataoka, Y
   Nicholls, SJ
AF Puri, Rishi
   MyNgan Duong
   Uno, Kiyoko
   Kataoka, Yu
   Nicholls, Stephen J.
TI The emerging role of plasma lipidomics in cardiovascular drug discovery
SO EXPERT OPINION ON DRUG DISCOVERY
LA English
DT Review
DE cardiovascular; drug development; drug discovery; lipidomics
ID IMAGING MASS-SPECTROMETRY; CORONARY-ARTERY-DISEASE; RANDOMIZED
   CONTROLLED-TRIAL; AVERAGE CHOLESTEROL LEVELS; ELECTROSPRAY-IONIZATION;
   HEART-DISEASE; MYOCARDIAL-INFARCTION; METABOLIC SYNDROME; OXIDATIVE
   STRESS; SYSTEMS BIOLOGY
AB Introduction: With the rising global incidence of cardiovascular disease, the challenge for the pharmaceutical industry is to identify novel biomarkers that will allow not only for the development of the next generation of cardiometabolic therapeutics, but also to serve as a sensitive mechanism to monitor and predict drug efficacy and potential toxicity. The advent of an 'omics' (systems biological) approach has vast implications for future disease treatment and prevention. Lipidomics is the latest addition to the 'omics' family and is rapidly gaining attention due to the technological improvements in mass spectrometry, allowing for the characterization of large number of lipids (and their respective subclasses) in a short amount of time with relatively minimal preparation.
   Areas covered: The authors discuss the various techniques involved in plasma lipidomics as well as outline the role that lipidomics will play in phenotyping disease processes and corresponding therapeutic strategies. The article was formed through comprehensive Medline search of relevant publications in this area.
   Expert opinion: Despite the wealth of data that will emerge regarding the various lipid-molecular interactions and the functions of lipids within cells, a major challenge will be the parallel emergence of novel bioinformatics platforms in order to integrate this enormous data set with information generated from the emerging fields of genomics and proteomic analysis. Despite these challenges, lipidomics is likely to result in the reclassification of diseases from a molecular perspective and play a key role the eventuation of personalized medicine.
C1 [Puri, Rishi; Uno, Kiyoko; Kataoka, Yu; Nicholls, Stephen J.] Cleveland Clin, Dept Cardiovasc Med, Inst Heart & Vasc, Cleveland, OH 44106 USA.
   [MyNgan Duong; Nicholls, Stephen J.] Cleveland Clin, Lerner Res Inst, Dept Cell Biol, Cleveland, OH 44106 USA.
C3 Cleveland Clinic Foundation; Cleveland Clinic Foundation
RP Nicholls, SJ (corresponding author), Cleveland Clin, Dept Cardiovasc Med, Inst Heart & Vasc, Mail Code JJ 65,9500 Euclid Ave, Cleveland, OH 44106 USA.
EM nichols1@ccf.org
OI Nicholls, Stephen/0000-0002-9668-4368
FU National Health & Medical Research Council [565579]; National Heart
   Foundation of Australia [PC0804045]; Dawes Scholarships (Hanson
   Institute); AstraZeneca; Novartis; Resver-logix; Eli Lilly Co.; Anthera
FX R Puri is jointly supported by a Postgraduate Medical Research
   Scholarship from the National Health & Medical Research Council
   (565579), National Heart Foundation of Australia (PC0804045) and Dawes
   Scholarships (Hanson Institute). SJ Nicholls receives honoraria from
   AstraZeneca, Merck and Co., Takeda Pharmaceutical Co. and Roche and is a
   consultant to Pfizer, AstraZeneca, Merck and Co., Takeda Pharmaceutical
   Co., Anthera, and NovoNordisk. He also receives research support from
   AstraZeneca, Novartis, Resver-logix, Eli Lilly & Co., and Anthera. All
   other authors declare that they have no conflict of interest and have
   received no payment in the preparation of this manuscript.
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NR 69
TC 19
Z9 21
U1 1
U2 21
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1746-0441
EI 1746-045X
J9 EXPERT OPIN DRUG DIS
JI Expert. Opin. Drug Discov.
PD JAN
PY 2012
VL 7
IS 1
BP 63
EP 72
DI 10.1517/17460441.2012.644041
PG 10
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 870JM
UT WOS:000298665400005
PM 22468894
DA 2025-06-11
ER

PT J
AU Tucci, S
   Flögel, U
   Sturm, M
   Borsch, E
   Spiekerkoetter, U
AF Tucci, Sara
   Floegel, Ulrich
   Sturm, Marga
   Borsch, Elena
   Spiekerkoetter, Ute
TI Disrupted fat distribution and composition due to medium-chain
   triglycerides in mice with a β-oxidation defect
SO AMERICAN JOURNAL OF CLINICAL NUTRITION
LA English
DT Article
ID CATALYTIC ACTIVITY CONCENTRATIONS; NONALCOHOLIC STEATOHEPATITIS;
   INSULIN-RESISTANCE; SKELETAL-MUSCLE; ACIDS; MECHANISMS; ENZYMES;
   37-DEGREES-C; EXPRESSION; STEATOSIS
AB Background: Because of the enhanced recognition of inherited long-chain fatty acid oxidation disorders by worldwide newborn screening programs, an increasing number of asymptomatic patients receive medium-chain triglyceride (MCT) supplements to prevent the development of cardiomyopathy and myopathy.
   Objective: MCT supplementation has been recognized as a safe dietary intervention, but long-term observations into later adulthood are still not available. We investigated the consequences of a prolonged MCT diet on abdominal fat distribution and composition and on liver fat.
   Design: Mice with very-long-chain acyl-coenzyme A dehydrogenase deficiency (VLCAD(-/-)) were supplemented for 1 y with a diet in which MCTs replaced long-chain triglycerides without increasing the total fat content. The dietary effects on abdominal fat accumulation and composition were analyzed by in vivo H-1- and C-13-magnetic resonance spectroscopy (9.4 Tesla).
   Results: After 1 y of MCT supplementation, VLCAD(-/-) mice accumulated massive visceral fat and had a dramatic increase in the concentration of serum free fatty acids. Furthermore, we observed a profound shift in body triglyceride composition, ie, concentrations of physiologically important polyunsaturated fatty acids dramatically decreased. H-1-Magnetic resonance spectroscopy analysis and histologic evaluation of the liver also showed pronounced fat accumulation and marked oxidative stress.
   Conclusion: Although the MCT-supplemented diet has been reported to prevent the development of cardiomyopathy and skeletal myopathy in fatty acid oxidation disorders, our data show that long-term MCT supplementation results in a severe clinical phenotype similar to that of nonalcoholic steatohepatitis and the metabolic syndrome. Am J Clin Nutr 2011;94:439-49.
C1 [Tucci, Sara; Sturm, Marga; Spiekerkoetter, Ute] Univ Childrens Hosp, Dept Gen Pediat, D-40225 Dusseldorf, Germany.
   [Floegel, Ulrich] Univ Dusseldorf, Dept Cardiovasc Physiol, Dusseldorf, Germany.
   [Borsch, Elena] Univ Dusseldorf, Dept Gastroenterol Hepatol & Infectiol, Dusseldorf, Germany.
C3 Heinrich Heine University Dusseldorf; Heinrich Heine University
   Dusseldorf
RP Tucci, S (corresponding author), Univ Childrens Hosp, Dept Gen Pediat, Moorenstr 5, D-40225 Dusseldorf, Germany.
EM sara.tucci@med.uni-duesseldorf.de
RI Flögel, Ulrich/AFO-8602-2022; Scarpa, Maurizio/AAC-1467-2019
OI Spiekerkoetter, Ute/0000-0002-5385-6705
FU Deutsche Forschungsgemeinschaft (DFG) [SP1125/1-1, SFB 575, SFB 612];
   Forschungskommission of the Medical Faculty of Heinrich-Heine-University
   Dusseldorf
FX Supported by grants from the Deutsche Forschungsgemeinschaft (DFG
   SP1125/1-1, SFB 575, and SFB 612) and the Forschungskommission of the
   Medical Faculty of Heinrich-Heine-University Dusseldorf.
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NR 53
TC 29
Z9 32
U1 0
U2 9
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0002-9165
EI 1938-3207
J9 AM J CLIN NUTR
JI Am. J. Clin. Nutr.
PD AUG
PY 2011
VL 94
IS 2
BP 439
EP 449
DI 10.3945/ajcn.111.012948
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 794TT
UT WOS:000292924900012
PM 21697078
DA 2025-06-11
ER

PT J
AU Ozgen, M
   Koca, SS
   Aksoy, K
   Dagli, N
   Ustundag, B
   Isik, A
AF Ozgen, Metin
   Koca, Suleyman Serdar
   Aksoy, Kader
   Dagli, Necati
   Ustundag, Bilal
   Isik, Ahmet
TI Visfatin levels and intima-media thicknesses in rheumatic diseases
SO CLINICAL RHEUMATOLOGY
LA English
DT Article
DE Chronic inflammation; IMT; Insulin resistance; Visfatin
ID COLONY-ENHANCING FACTOR; INSULIN-RESISTANCE; SYSTEMIC-SCLEROSIS;
   METABOLIC SYNDROME; REVISED CRITERIA; OXIDATIVE STRESS; ACTIVITY INDEX;
   INFLAMMATION; ARTHRITIS; ATHEROSCLEROSIS
AB Chronic inflammatory rheumatic diseases lead to increased prevalence of atherosclerosis. However, this early and accelerated atherosclerosis cannot be explained by traditional cardiovascular risk factors alone. The permanent overexpression of cellular adhesion molecules and pro-inflammatory cytokines in chronic inflammatory conditions may participate in accelerated atherosclerosis. Visfatin, a novel adipocytokine, has a potential insulin-like action and pro-inflammatory effects. Therefore, the aim of the study was to determine serum visfatin level and its association with common carotid intima-media thickness (IMT), which is a predictor of atherosclerosis, in patients with rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), systemic sclerosis (SSc), and Beh double dagger et's disease (BD). The study involved 29 RA, 26 SLE, 25 SSc, 30 BD patients, and 29 healthy controls (HC). Serum levels of TNF-alpha, IL-6, and visfatin were analyzed using enzyme-linked immunosorbent assay method and homeostasis model assessment for insulin resistance (HOMA-IR) indexes, and IMTs were determined. Serum visfatin level was higher in the RA group than all the other groups. In addition, visfatin level was higher in the active BD subgroup than the inactive BD subgroup. In the study groups, visfatin levels were not correlated with HOMA-IR indexes and IMTs. Whereas visfatin serum concentration was not associated with insulin resistance and carotid atherosclerosis in selected rheumatic diseases, it was higher in the RA and active BD groups, but not in the SLE and SSc groups. Visfatin levels may be associated with Th1/Th2 balance. Further studies are needed for more precise elucidation of the pro-inflammatory activities of visfatin.
C1 [Ozgen, Metin; Koca, Suleyman Serdar; Isik, Ahmet] Firat Univ, Dept Rheumatol, Fac Med, TR-23169 Elazig, Turkey.
   [Aksoy, Kader] Firat Univ, Dept Endocrinol, Fac Med, TR-23169 Elazig, Turkey.
   [Dagli, Necati] Firat Univ, Dept Cardiol, Fac Med, TR-23169 Elazig, Turkey.
   [Ustundag, Bilal] Firat Univ, Dept Biochem, Fac Med, TR-23169 Elazig, Turkey.
C3 Firat University; Firat University; Firat University; Firat University
RP Koca, SS (corresponding author), Firat Univ, Dept Rheumatol, Fac Med, TR-23169 Elazig, Turkey.
EM kocassk@yahoo.com
RI ÜSTÜNDAĞ, BİLAL/V-9780-2018; Uğur, Kader/W-7053-2018; KOCA, SULEYMAN
   SERDAR/W-6395-2018
OI Koca, Suleyman Serdar/0000-0003-4995-430X; UGUR,
   KADER/0000-0003-4028-2041; Ustundag, Bilal/0000-0001-6621-2450
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NR 46
TC 42
Z9 42
U1 0
U2 4
PU SPRINGER LONDON LTD
PI LONDON
PA 236 GRAYS INN RD, 6TH FLOOR, LONDON WC1X 8HL, ENGLAND
SN 0770-3198
EI 1434-9949
J9 CLIN RHEUMATOL
JI Clin. Rheumatol.
PD JUN
PY 2011
VL 30
IS 6
BP 757
EP 763
DI 10.1007/s10067-010-1649-2
PG 7
WC Rheumatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Rheumatology
GA 768TG
UT WOS:000290960700003
PM 21165753
DA 2025-06-11
ER

PT J
AU Potpara, TS
   Lip, GYH
AF Potpara, T. S.
   Lip, G. Y. H.
TI Lone atrial fibrillation: what is known and what is to come
SO INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
LA English
DT Review
ID OF-FUNCTION MUTATION; C-REACTIVE PROTEIN; NATRIURETIC PEPTIDE LEVELS;
   INDEPENDENT RISK-FACTORS; OBSTRUCTIVE SLEEP-APNEA; 30-YEAR FOLLOW-UP;
   CARDIOVASCULAR EVENTS; ALCOHOL-CONSUMPTION; NATURAL-HISTORY; SPORT
   PRACTICE
AB P>Atrial fibrillation (AF) is the most prevalent sustained cardiac arrhythmia in adults, affecting > 1% of general population. Atrial fibrillation is commonly associated with structural heart disease and is a major cause of significant cardiovascular morbidity and mortality. AF sometimes develops in a subset of young patients (e.g. aged < 60 years), with no evidence of associated cardiopulmonary or other comorbid disease (including hypertension), and has been referred to as 'lone AF'. The latter generally has a favourable prognosis; the prognostic and therapeutic implications of an accurate identification of patients with truly lone AF (that is, truly at low risk of complications), if any, would be of the utmost importance. The true prevalence of lone AF is unknown, varying between 1.6% and 30%, depending on the particular study population. Nonetheless, novel risk factors for AF, including obesity, metabolic syndrome, sleep apnea, alcohol consumption, endurance sports, anger, hostility, subclinical atherosclerosis and others, have been increasingly recognised. Also, various underlying pathophysiological mechanisms predisposing to AF, including increased atrial stretch, structural and electrophysiological alterations, autonomic imbalance, systemic inflammation, oxidative stress and genetic predisposition, have been proposed. The growing evidence of these diverse (and numerous) pathogenic mechanisms and factors related to AF inevitably raises the question of whether 'lone AF' does exist at all. In this review article, we summarise the current knowledge of the epidemiology, pathophysiology, clinical course and treatment of patients with so-called 'lone AF' and outline emerging insights into its pathogenesis and the potential therapeutic implications of a diagnosis of lone AF.
C1 [Lip, G. Y. H.] Univ Birmingham, Ctr Cardiovasc Sci, City Hosp, Birmingham B18 7QH, W Midlands, England.
   [Potpara, T. S.] Clin Ctr Serbia, Univ Cardiol Clin, Belgrade, Serbia.
C3 University of Birmingham; Clinical Centre of Serbia
RP Lip, GYH (corresponding author), Univ Birmingham, Ctr Cardiovasc Sci, City Hosp, Birmingham B18 7QH, W Midlands, England.
EM g.y.h.lip@bham.ac.uk
RI Lip, Gregory/AEO-0575-2022; Potpara, Tatjana/AFC-8820-2022
OI Potpara, Tatjana/0000-0001-6285-6902
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NR 143
TC 49
Z9 53
U1 0
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1368-5031
EI 1742-1241
J9 INT J CLIN PRACT
JI Int. J. Clin. Pract.
PD APR
PY 2011
VL 65
IS 4
BP 446
EP 457
DI 10.1111/j.1742-1241.2010.02618.x
PG 12
WC Medicine, General & Internal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Pharmacology & Pharmacy
GA 735ZC
UT WOS:000288458300014
PM 21219558
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Shati, AA
   Alamri, SA
AF Shati, Ali A.
   Alamri, Saad A.
TI Role of saffron (Crocus sativus L.) and honey syrup on
   aluminum-induced hepatotoxicity
SO SAUDI MEDICAL JOURNAL
LA English
DT Article
ID ALKALINE-PHOSPHATASE ACTIVITIES; HEALTH INTERVIEW SURVEY;
   LIPID-PEROXIDATION; VITAMIN-E; BIOCHEMICAL PARAMETERS; ANTIOXIDANT
   PROPERTIES; SEQUENCE ALIGNMENT; METABOLIC SYNDROME; ENZYME-ACTIVITIES;
   OXIDATIVE STRESS
AB Objectives: To study the biochemical and molecular hepatotoxicity induced by aluminium chloride (AlCl3) and the protective role of saffron and honey against such toxicity.
   Methods: This study was performed in the Department of Biology, College of Science, King Khalid University, Abha, Kingdom of Saudi Arabia between July and August 2009. Two mice strains, BALB/c and C57BL/6 (20 animals from each strain), were used and randomly divided into 4 groups: control group; AlCl3 group; AlCl3+saffron group; and AlCl3+honey group. Changes in liver biochemical markers such as gamma-glutamyl transpeptidase (GGT), alanine transaminase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and total bilirubin and lipid peroxidation levels were estimated. Induced and suppressed mRNA in the liver homogenate was scanned followed by up- and down-regulated genes were isolated, cloned, and sequenced.
   Results: There was a significant increase in the cholesterol levels, triglycerides, GGT, ALT, AST, ALP, lipid peroxidation, and presence of hyperglycemia in the AlCl3 group compared to the control. However, treating those animals exposed to AlCl3 by saffron and honey improved the disrupted liver biochemical markers and alleviated the increase of lipid peroxidation. Seven down-regulated genes (3 BALB/c and 4 C57BL/6) and 5 up-regulated genes (2 BALB/c and 3 C57BL/6) were observed. Aa2-245 gene was observed as being up-regulated in AlCl3+saffron and AlCl3+honey groups in the BALB/c strain.
   Conclusion: The use of saffron and honey minimized the toxic effect of AlCl3 in the liver by alleviating its disruptive effect on the biochemical and molecular levels.
C1 [Shati, Ali A.; Alamri, Saad A.] King Khalid Univ, Dept Biol, Coll Sci, Abha 61321, Saudi Arabia.
C3 King Khalid University
RP Shati, AA (corresponding author), King Khalid Univ, Dept Biol, Coll Sci, POB 10255, Abha 61321, Saudi Arabia.
EM shati100@yahoo.com
RI Shati, Ali/J-8491-2012; Alamri, Saad/AGM-5459-2022
OI Shati, Ali/0000-0003-1800-7238
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NR 61
TC 40
Z9 42
U1 0
U2 7
PU SAUDI MED J
PI RIYADH
PA ARMED FORCES HOSPITAL, PO BOX 7897,, RIYADH 11159, SAUDI ARABIA
SN 0379-5284
J9 SAUDI MED J
JI Saudi Med. J.
PD OCT
PY 2010
VL 31
IS 10
BP 1106
EP 1113
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 709AG
UT WOS:000286406800004
PM 20953525
DA 2025-06-11
ER

PT J
AU Kales, SN
   Tsismenakis, AJ
   Zhang, CB
   Soteriades, ES
AF Kales, Stefanos N.
   Tsismenakis, Antonios J.
   Zhang, Chunbai
   Soteriades, Elpidoforos S.
TI Blood-Pressure in Firefighters, Police Officers, and Other Emergency
   Responders
SO AMERICAN JOURNAL OF HYPERTENSION
LA English
DT Article
ID CORONARY-HEART-DISEASE; BODY-MASS INDEX; MIDDLE-AGED MEN; RISK-FACTORS;
   POSTTRAUMATIC-STRESS; NOISE EXPOSURE; SLEEP-APNEA; OCCUPATIONAL NOISE;
   UNITED-STATES; SHIFT WORK
AB Elevated blood pressure is a major risk factor for cardiovascular morbidity and mortality. Increased risk begins in the prehypertensive range and increases further with higher pressures. The strenuous duties of emergency responders (firefighters, police officers, and emergency medical services (EMS) personnel) can interact with their personal risk profiles, including elevated blood pressure, to precipitate acute cardiovascular events. Approximately three-quarters of emergency responders have prehypertension or hypertension, a proportion which is expected to increase, based on the obesity epidemic. Elevated blood pressure is also inadequately controlled in these professionals and strongly linked to cardiovascular disease morbidity and mortality. Notably, the majority of incident cardiovascular disease events occur in responders who are initially prehypertensive or only mildly hypertensive and whose average premorbid blood pressures are in the range in which many physicians would hesitate to prescribe medications (140-146/88-92). Laws mandating public benefits for emergency responders with cardiovascular disease provide an additional rationale for aggressively controlling their blood pressure. This review provides a background on emergency responders, summarizes occupational risk factors for hypertension and the metabolic syndrome, their prevalence of elevated blood pressure, and evidence linking hypertension with adverse outcomes in these professions. Next, discrepancies between relatively outdated medical standards for emergency responders and current, evidence-based guidelines for blood pressure management in the general public are highlighted. Finally, a workplace-oriented approach for blood pressure control among emergency responders is proposed, based on the seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure.
C1 [Kales, Stefanos N.; Tsismenakis, Antonios J.; Zhang, Chunbai; Soteriades, Elpidoforos S.] Harvard Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA 02115 USA.
   [Kales, Stefanos N.; Tsismenakis, Antonios J.] Harvard Univ, Sch Med, Cambridge Hlth Alliance, Boston, MA 02115 USA.
   [Tsismenakis, Antonios J.] Boston Univ, Sch Med, Boston, MA 02118 USA.
   [Soteriades, Elpidoforos S.] Cyprus Inst Biomed Sci CIBS, Dept Occupat & Environm Med, Nicosia, Cyprus.
C3 Harvard University; Harvard T.H. Chan School of Public Health; Harvard
   University; Harvard University Medical Affiliates; Cambridge Health
   Alliance; Harvard Medical School; Boston University
RP Kales, SN (corresponding author), Harvard Univ, Sch Publ Hlth, Dept Environm Hlth, 665 Huntington Ave, Boston, MA 02115 USA.
EM skales@challiance.org
OI Tsismenakis, Tony/0000-0003-4986-6641
FU US Department of Homeland Security [EMW-2006-FP-01 493]
FX The study was supported in part by grant number EMW-2006-FP-01 493 from
   the US Department of Homeland Security. The funding agency had no
   involvement in study design, data analysis, writing of the paper, and/or
   the decision to submit the paper for publication. The contents are
   solely the responsibility of the authors and do not necessarily reflect
   the views of the US Department of Homeland Security. S.N.K. conceived of
   the idea for the paper. A.J.T. and C.Z. identified the relevant
   literature. All authors reviewed part of the medical literature. S.N.K.
   and A.J.T. wrote the first draft of the manuscript. All authors
   contributed to, read and approved of the final version of the
   manuscript.
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NR 91
TC 140
Z9 182
U1 2
U2 22
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0895-7061
EI 1941-7225
J9 AM J HYPERTENS
JI Am. J. Hypertens.
PD JAN
PY 2009
VL 22
IS 1
BP 11
EP 20
DI 10.1038/ajh.2008.296
PG 10
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 387GM
UT WOS:000261939700007
PM 18927545
OA Bronze
DA 2025-06-11
ER

PT J
AU Ford, ES
   Schulze, MB
   Bergmann, MM
   Thamer, C
   Joost, HG
   Boeing, H
AF Ford, Earl S.
   Schulze, Matthias B.
   Bergmann, Manuela M.
   Thamer, Claus
   Joost, Hans-Georg
   Boeing, Heiner
TI Liver enzymes and incident diabetes - Findings from the European
   Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study
SO DIABETES CARE
LA English
DT Article
ID GAMMA-GLUTAMYL-TRANSFERASE; AGED JAPANESE MEN; METABOLIC SYNDROME;
   ALANINE AMINOTRANSFERASE; INSULIN-RESISTANCE; OXIDATIVE STRESS;
   EPIC-GERMANY; RISK-FACTORS; FOLLOW-UP; DISEASE
AB OBJECTIVE - We sought to examine the association between plasma concentrations of liver enzymes gamma-glutamyltransferase (GGT) and alanine transaminase (ALT) and incident diabetes, prospectively.
   RESEARCH DESIGN AND METHODS - We conducted a case-cohort analysis of data from participants mainly aged 35-65 years in the European Prospective Investigation into Cancer and Nutrition-Potsdam Study. The analytic sample included 787 participants with incident diabetes and 2,224 participants without diabetes.
   RESULTS - Concentrations of GGT and ALT were significantly associated with incident diabetes after extensive adjustment. Compared with participants in the lowest quintile of GGT, the adjusted hazard ratios for increasing quintiles were 1.13 (95% CI 0.66-1.93), 1.67 (1.01-2.77), 2.77 (1.71-4.49), and 2.67 (1.63-4.37), respectively (P for linear trend <0.001). Compared with participants in the lowest quintile of ALT, the adjusted hazard ratios for incident diabetes were 0.93 (0.56-1.53) for quintile 2, 1.28 (0.83-1.96) for quintile 3, 1.35 (0.88-2.07) for quintile 4, and 1.93 (1.27-2.92) for quintile 5 (P for linear trend = 0.002). The magnitude of the associations were higher among men than women for GGT (P = 0.004) but did not differ significantly between men and women for ALT (P = 0.307).
   CONCLUSIONS - Concentrations of GGT and ALT were significant predictors of incident diabetes in this study, even at concentrations still considered to be within the normal range.
C1 [Schulze, Matthias B.; Bergmann, Manuela M.; Boeing, Heiner] German Inst Human Nutr Potsdam Rehbrucke, Dept Epidemiol, D-14558 Nuthetal, Germany.
   [Ford, Earl S.] Ctr Dis Control & Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Div Adult & Community Hlth, Atlanta, GA USA.
   [Thamer, Claus] Univ Tubingen, Dept Internal Med 4, Tubingen, Germany.
   [Joost, Hans-Georg] German Inst Human Nutr Potsdam Rehbrucke, Dept Pharmacol, D-14558 Nuthetal, Germany.
C3 Leibniz Association; Deutsches Institut fur Ernahrungsforschung
   Potsdam-Rehbrucke (DIfE); Centers for Disease Control & Prevention -
   USA; Eberhard Karls University of Tubingen; Leibniz Association;
   Deutsches Institut fur Ernahrungsforschung Potsdam-Rehbrucke (DIfE)
RP Schulze, MB (corresponding author), German Inst Human Nutr Potsdam Rehbrucke, Dept Epidemiol, ArLhur Scheunert Allee 114-115, D-14558 Nuthetal, Germany.
EM mschulze@dife.de
RI Joost, Hans-Georg/J-4462-2013; Schulze, Matthias B./AAH-6906-2021
OI Joost, Hans-Georg/0000-0002-5860-606X; Schulze, Matthias
   B./0000-0002-0830-5277
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NR 26
TC 85
Z9 92
U1 0
U2 12
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0149-5992
J9 DIABETES CARE
JI Diabetes Care
PD JUN
PY 2008
VL 31
IS 6
BP 1138
EP 1143
DI 10.2337/dc07-2159
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 313RZ
UT WOS:000256759000010
PM 18955714
OA Bronze
DA 2025-06-11
ER

PT J
AU Griffin, JL
   Scott, J
   Nicholson, JK
AF Griffin, Julian L.
   Scott, James
   Nicholson, Jeremy K.
TI The influence of pharmacogenetics on fatty liver disease in the Wistar
   and Kyoto rats: A combined transcriptomic and metabonomic study
SO JOURNAL OF PROTEOME RESEARCH
LA English
DT Article
DE metabolomics; metabolic profiling; pattern recognition; nonalcoholic
   steatohepatisis
ID OROTIC ACID; NONALCOHOLIC STEATOHEPATITIS; EXPRESSION; H-1
AB Although fatty liver disease is caused by a number of toxicological insults and the metabolic syndrome, the exact mechanisms by which many of these pathophysiological stimulii induce fatty liver are unknown. The rapid and profound steatosis caused by orotic acid, resulting from an impairment in the production of ApoB, has been investigated in the Wistar strain rat using a combined transcriptomic and metabonomic/metabolomic approach. Analysis of liver tissue from rats exposed to orotic acid for 1, 3, and 14 days was performed by DNA microarrays and high resolution H-1 NMR spectroscopy based metabonomics of both tissue extracts and intact tissue (n = 3). Data were analyzed using a combination of ANOVA and principal components analysis, used as a data reduction tool to visualize the most perturbed transcripts and metabolites. Orotic acid produced a profound 8-fold increase in total lipids, and in particular increases in resonances associated with polyunsaturated fats (CHCH and CH2CHCH groups). This was accompanied by increases in the concentrations of trimethylamine-oxide (TMAO), betaine, choline, and phosphocholine, as well as a relative decrease in glucose and glycogen. At the transcriptional level, perturbations were detected in both oxidative stress and osmoregulation/pH homeostasis. However, this contrasts with a previous transcriptomic/metabolic study of fatty liver disease in a combined data set of Wistar (out-bred) and Kyoto (in-bred) strains of rats, with only 4 transcripts being found to be in common between the two analyses. This emphasizes the need to understand how strain background interacts with a given toxic lesion or genetic modification.
C1 Univ Cambridge, Dept Biochem, Cambridge CB2 1GA, England.
   Univ London Imperial Coll Sci Technol & Med, Fac Med, Genet & Genom Res Inst, London SW7 2AZ, England.
C3 University of Cambridge; Imperial College London
RP Griffin, JL (corresponding author), Univ Cambridge, Dept Biochem, Cambridge CB2 1GA, England.
EM jlg40@mole.bio.cam.ac.uk
RI Nicholson, Jeremy/IXE-0082-2023; Nicholson, Jeremy Kirk/B-3395-2012
OI Nicholson, Jeremy Kirk/0000-0002-8123-8349; Lindon,
   John/0000-0002-0916-6360; Holmes, Elaine/0000-0002-0556-8389
FU Wellcome Trust Funding Source: Medline
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NR 20
TC 35
Z9 38
U1 0
U2 20
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1535-3893
EI 1535-3907
J9 J PROTEOME RES
JI J. Proteome Res.
PD JAN 5
PY 2007
VL 6
IS 1
BP 54
EP 61
DI 10.1021/pr0601640
PG 8
WC Biochemical Research Methods
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 122YD
UT WOS:000243262600004
PM 17203948
DA 2025-06-11
ER

PT J
AU Gharib, A
   Marquez, C
   Meseguer-Beltran, M
   Sanchez-Sarasua, S
   Sanchez-Perez, AM
AF Gharib, Amir
   Marquez, Carlee
   Meseguer-Beltran, Maria
   Sanchez-Sarasua, Sandra
   Sanchez-Perez, Ana M.
TI Abscisic acid, an evolutionary conserved hormone: Biosynthesis,
   therapeutic and diagnostic applications in mammals
SO BIOCHEMICAL PHARMACOLOGY
LA English
DT Review
DE Mammalian hormone; Therapeutic applications; Biomarker tool; Immune
   modulation; Animal model; Neurological disorders
ID CYCLIC ADP-RIBOSE; BITTER TASTE RECEPTORS; PPAR-GAMMA; METABOLIC
   SYNDROME; RETINOIC ACID; PHYTOHORMONE; CELLS; CALCIUM; SENSITIVITY;
   ALZHEIMERS
AB Abscisic acid (ABA), a phytohormone traditionally recognized for its role in plant stress responses, has recently emerged as a significant player in mammalian defense mechanisms. Like plants, various mammalian cell types synthesize ABA in response to specific health challenges, although the precise pathways remain not fully elucidated. ABA is associated with the regulation of inflammation and insulin signaling, prompting extensive research into its potential as a therapeutic agent for various diseases. ABA exerts its effects through its receptors, particularly PPAR-gamma and LANCL-2, which serve as signaling hubs regulating numerous pathways. Through these interactions, ABA profoundly impacts mammalian health, and new ABA targets continue to be identified. Numerous studies in animal models demonstrate ABA's benefit in managing conditions such as neurological and psychiatric disorders, cancer, and malaria infections, all of which involve significant inflammatory dysregulation. In this manuscript we review the studies covering ABA synthesis and release in cell cultures, the signaling pathways regulated by ABA, and how these impact health in preclinical models. Furthermore, we highlight recent research suggesting that measuring ABA levels in human body fluids could serve as a useful biomarker for pathological conditions, providing insights into disease progression and treatment efficacy. This comprehensive review outlines the current understanding of ABA in mammalian pathophysiology, identifying gaps in knowledge, particularly concerning ABA biosynthesis and metabolism in mammals. In addition, this study emphasizes the need for clinical trials to validate the effectiveness of ABA-based therapies and its reliability as a biomarker for various diseases.
C1 [Gharib, Amir; Marquez, Carlee; Meseguer-Beltran, Maria; Sanchez-Sarasua, Sandra; Sanchez-Perez, Ana M.] Univ Jaume 1, Inst Adv Mat INAM, Neurobiotecnol Grp, Avda Vicent Sos Baynat S-N, Castellon de La Plana 12071, Spain.
   [Gharib, Amir] Islamic Azad Univ, Dept Lab Sci, Borujerd Branch, Borujerd, Iran.
   [Sanchez-Sarasua, Sandra] Univ Bordeaux, Inst Malad Neurodegenerat, Ctr Paul Broca Nouvelle Aquitaine, CNRS UMR 5293, Bordeaux, France.
C3 Universitat Jaume I; Islamic Azad University; Centre National de la
   Recherche Scientifique (CNRS); Universite de Bordeaux; CNRS - National
   Institute for Biology (INSB)
RP Sanchez-Sarasua, S; Sanchez-Perez, AM (corresponding author), Univ Jaume 1, Inst Adv Mat INAM, Neurobiotecnol Grp, Avda Vicent Sos Baynat S-N, Castellon de La Plana 12071, Spain.
EM sarasuad@uji.es; sanchean@uji.es
RI Sanchez-Perez, Ana Maria/AAB-4454-2019; Sanchez-Sarasua,
   Sandra/JLL-2630-2023
OI Sanchez-Sarasua, Sandra/0000-0002-9759-1665; Sanchez-Perez, Ana
   Maria/0000-0002-5811-0005
FU Plan Propi UJI [UJI-B2021-21]; Margarita Salas postdoctoral contract -
   NextGenerationEU [MGS/2021/33 (UP2021-021)]; US Fulbright Student
   Program fellowship
FX This research was supported by Plan Propi UJI (UJI-B2021-21) to AMSP.
   SSS was supported by the Margarita Salas postdoctoral contract
   MGS/2021/33 (UP2021-021) financed by the NextGenerationEU. CM was
   supported by the US Fulbright Student Program fellowship, and MMB was
   supported by contract associated to Koplowitz foundation.
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NR 151
TC 7
Z9 7
U1 8
U2 19
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0006-2952
EI 1873-2968
J9 BIOCHEM PHARMACOL
JI Biochem. Pharmacol.
PD NOV
PY 2024
VL 229
AR 116521
DI 10.1016/j.bcp.2024.116521
EA SEP 2024
PG 18
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA G4Y9D
UT WOS:001316721800001
PM 39251140
OA hybrid
DA 2025-06-11
ER

PT J
AU Lko, ABS
   Gostomska-Pampuch, K
   Kuzan, A
   Pietkiewicz, J
   Krzystek-Korpacka, ML
   Gamian, A
AF Lko, Agnieszka Bronowicka-Szyde
   Gostomska-Pampuch, Kinga
   Kuzan, Aleksandra
   Pietkiewicz, Jadwiga
   Krzystek-Korpacka, Ma lgorzata
   Gamian, Andrzej
TI Effect of advanced glycation end-products in a wide range of medical
   problems including COVID-19
SO ADVANCES IN MEDICAL SCIENCES
LA English
DT Review
DE Advanced glycation end-products; Diabetes; Alzheimer's disease;
   Metabolic diseases; COVID-19
ID RETINAL MICROVASCULAR CELLS; ALDOSE REDUCTASE INHIBITION; ENDOTHELIAL
   GROWTH-FACTOR; CROSS-LINK BREAKER; DIABETES-MELLITUS; OXIDATIVE STRESS;
   PROTEIN GLYCATION; N-EPSILON-(CARBOXYMETHYL) LYSINE; ADVANCED
   GLYCOXIDATION; ALZHEIMERS-DISEASE
AB Glycation is a physiological process that determines the aging of the organism, while in states of metabolic disorders it is significantly intensified. High concentrations of compounds such as reducing sugars or reactive aldehydes derived from lipid oxidation, occurring for example in diabetes, atherosclerosis, dyslipidemia, obesity or metabolic syndrome, lead to increased glycation of proteins, lipids and nucleic acids. The level of advanced glycation end -products (AGEs) in the body depends on rapidity of their production and the rate of their removal by the urinary system. AGEs, accumulated in the extracellular matrix of the blood vessels and other organs, cause irreversible changes in the biochemical and biomechanical properties of tissues. As a consequence, micro- and macroangiopathies appear in the system, and may contribute to the organ failure, like kidneys and heart. Elevated levels of AGEs also increase the risk of Alzheimer's disease and various cancers. In this paper, we propose a new classification due to modified amino acid residues: arginyl-AGEs, monolysyl-AGEs and lysyl-arginyl-AGEs and dilysyl-AGEs. Furthermore, we describe in detail the effect of AGEs on the pathogenesis of metabolic and old age diseases, such as diabetic complications, atherosclerosis and neurodegenerative diseases. We summarize the currently available data on the diagnostic value of AGEs and present the AGEs as a therapeutic goal in a wide range of medical problems, including SARS-CoV-2 infection and so-called long COVID.
C1 [Lko, Agnieszka Bronowicka-Szyde; Gostomska-Pampuch, Kinga; Kuzan, Aleksandra; Pietkiewicz, Jadwiga; Krzystek-Korpacka, Ma lgorzata] Wroclaw Med Univ, Dept Med Biochem, Wroclaw, Poland.
   [Gamian, Andrzej] Polish Acad Sci, Hirszfeld Inst Immunol & Expt Therapy, Dept Immunol Infect Dis, Wroclaw, Poland.
C3 Wroclaw Medical University; Polish Academy of Sciences; Hirszfeld
   Institute of Immunology & Experimental Therapy of the Polish Academy of
   Sciences
RP Kuzan, A (corresponding author), Wroclaw Med Univ, Dept Med Biochem, Wroclaw, Poland.
EM aleksandra.kuzan@umw.edu.pl
RI Kuzan, Aleksandra/AAZ-4028-2021; Gostomska-Pampuch, Kinga/AAZ-3984-2021;
   Bronowicka-Szydełko, Agnieszka/AAZ-8994-2021; Krzystek-Korpacka,
   Małgorzata/ABA-4556-2021; Wiśniewski, Jerzy/HKO-2228-2023
OI Bronowicka-Szydelko, Agnieszka/0000-0001-9967-036X; Gostomska-Pampuch,
   Kinga/0000-0002-0771-3893
FU National Science Centre, Poland [2021/43/D/NZ5/02471]
FX The knowledge presented in this publication was acquired during the
   implementation of grant number 2021/43/D/NZ5/02471 funded by National
   Science Centre, Poland.
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NR 232
TC 9
Z9 9
U1 4
U2 9
PU ELSEVIER URBAN & PARTNER SP Z O O
PI WROCLAW
PA UL MIGDALOWA 4, LOK 59, WROCLAW, 02-796, POLAND
SN 1896-1126
EI 1898-4002
J9 ADV MED SCI-POLAND
JI Adv. Med. Sci.
PD MAR
PY 2024
VL 69
IS 1
BP 36
EP 50
DI 10.1016/j.advms.2024.01.003
EA FEB 2024
PG 15
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA KU3L7
UT WOS:001182438300001
PM 38335908
OA hybrid
DA 2025-06-11
ER

PT J
AU Wang, LW
   Chen, Q
   Ma, R
   Zhang, BK
   Yang, P
   Cao, T
   Jiao, SM
   Chen, H
   Lin, CQ
   Cai, HL
AF Wang, Liwei
   Chen, Qian
   Ma, Rui
   Zhang, Bikui
   Yang, Ping
   Cao, Ting
   Jiao, Shimeng
   Chen, Hui
   Lin, Chenquan
   Cai, Hualin
TI Insight into mitochondrial dysfunction mediated by clozapine-induced
   inhibition of PGRMC1 in PC12 cells
SO TOXICOLOGY
LA English
DT Article
DE Clozapine; PGRMC1; Neurotoxicity; Mitochondria function; Oxidative
   stress; Surface plasmon resonance
ID MEMBRANE COMPONENT 1; METABOLIC SYNDROME; ENERGY-METABOLISM; MITOFUSIN
   2; PROGESTERONE; SCHIZOPHRENIA; NEUROTOXICITY; MECHANISMS; RESISTANCE;
   OXIDATION
AB Clozapine is usually considered as the last resort for treatment-resistant schizophrenia (TRS). However, it shows limited efficacy in cognition improvement. Moreover, the metabolic side effects induced by clozapine can aggravate cognitive impairment, which is closely related to its neurotoxicity. Nevertheless, the mechanisms underlying clozapine's neurotoxicity remain largely elusive. In this study, PC12 cells were simultaneously treated with different concentrations (0 mu M, 10 mu M, 20 mu M, 40 mu M and 80 mu M) of clozapine and AG205 which functions as a blocking reagent of progesterone receptor membrane component 1 (PGRMC1). In addition, we examined the effect of PGRMC1 in clozapine-induced neurotoxicity through overexpressing or downregulating PGRMC1. Molecular docking and surface plasmon resonance (SPR) analysis indicated that clozapine and AG205 inhibited the binding of endogenous progesterone to PGRMC1. The results showed that high concentration of clozapine and AG205 induced a significant increase in cytotoxicity, reactive oxygen species (ROS) accumulation and mitochondrial membrane potential (MMP) collapse, all of which were worsened as concentration increases, while overexpression of PGRMC1 reverted the above toxic effect of clozapine on PC12 cells. Furthermore, clozapine and AG205 also downregulated the expression of PGRMC1, glucagon-like peptide-1 receptor (GLP-1R) and mitofusin2 (Mfn2). Interestingly, overexpression of PGRMC1 could revert these effects. Our data suggest that overexpression of PGRMC1 in PC12 cells prevents and restores clozapine-induced oxidative and mitochondrial damage. We propose PGRMC1 activation as a promising therapeutic strategy for clozapine-induced neurotoxicity to facilitate the relief of neuronal damage.
C1 [Wang, Liwei; Chen, Qian; Ma, Rui; Zhang, Bikui; Cao, Ting; Jiao, Shimeng; Chen, Hui; Lin, Chenquan; Cai, Hualin] Cent South Univ, Xiangya Hosp 2, Dept Pharm, Changsha 410011, Hunan, Peoples R China.
   [Wang, Liwei; Chen, Qian; Ma, Rui; Zhang, Bikui; Cao, Ting; Jiao, Shimeng; Chen, Hui; Lin, Chenquan; Cai, Hualin] Cent South Univ, Inst Clin Pharm, Changsha 410011, Hunan, Peoples R China.
   [Yang, Ping] Hunan Brain Hosp, Dept Psychiat, 427 Furong Rd, Changsha 410000, Hunan, Peoples R China.
   [Cai, Hualin] Int Res Ctr Precis Med Transformat Technol & Softw, Changsha, Hunan, Peoples R China.
   [Cai, Hualin] 139 Middle Renmin Rd, Changsha 430022, Hunan, Peoples R China.
C3 Central South University; Central South University
RP Cai, HL (corresponding author), 139 Middle Renmin Rd, Changsha 430022, Hunan, Peoples R China.
EM hualincai@csu.edu.cn
FU Hunan Provincial Natural Science Foundation of China [2021JJ30922];
   Hunan Provincial Health Commission Research Project [202113010595]; Wu
   Jieping Medical Foundation Funded Special Clinical Research Project
   [320.6750.2020-04-2]; Changsha Municipal Natural Science Foundation
   [kq2007045]; Fundamental Research Funds for the Central Universities of
   Central South University [[2021] 94]; New Clinical Medical Technology
   Project of the Second Xiangya Hospital of Central South University
   [CPA-Z05-ZC-2021- 003]; Chinese Pharmaceutical Association Hospital
   Pharmacy Department;  [2021zzts1073]
FX This work was supported in part by the grants from Hunan Provincial
   Natural Science Foundation of China (2021JJ30922) , Hunan Provincial
   Health Commission Research Project (202113010595) , Wu Jieping Medical
   Foundation Funded Special Clinical Research Project (320.6750.2020-04-2)
   , Changsha Municipal Natural Science Founda- tion (kq2007045) , Talent
   Project established by Chinese Pharmaceutical Association Hospital
   Pharmacy Department (No. CPA-Z05-ZC-2021- 003) , the Fundamental
   Research Funds for the Central Universities of Central South University
   (2021zzts1073) , and New Clinical Medical Technology Project of the
   Second Xiangya Hospital of Central South University ( [2021] 94) .
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NR 92
TC 2
Z9 2
U1 2
U2 9
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0300-483X
EI 1879-3185
J9 TOXICOLOGY
JI Toxicology
PD JUN 1
PY 2023
VL 491
AR 153515
DI 10.1016/j.tox.2023.153515
EA APR 2023
PG 12
WC Pharmacology & Pharmacy; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Toxicology
GA G1SM1
UT WOS:000987038500001
PM 37087062
DA 2025-06-11
ER

PT J
AU Liu, H
   Guan, H
   Tan, XT
   Jiang, Y
   Li, F
   Sun-Waterhouse, D
   Li, DP
AF Liu, Hui
   Guan, Hui
   Tan, Xintong
   Jiang, Yang
   Li, Feng
   Sun-Waterhouse, Dongxiao
   Li, Dapeng
TI Enhanced alleviation of insulin resistance via the IRS-1/Akt/FOXO1
   pathway by combining quercetin and EGCG and involving miR-27a-3p and
   miR-96-5p
SO FREE RADICAL BIOLOGY AND MEDICINE
LA English
DT Article
DE Insulin resistance; Flavonoid combination; miRNAs; Synergistic effect;
   FOXO1
ID HIGH-FAT DIET; METABOLIC SYNDROME; OXIDATIVE STRESS; ADIPOSE-TISSUE;
   GLUCOSE-UPTAKE; EXPRESSION; GLUCONEOGENESIS; INFLAMMATION; MICRORNAS;
   HYPERGLYCEMIA
AB Quercetin and EGCG exhibit anti-diabetic and anti-obesity activities, however, their interactive effects in antidiabetic/anti-obesity actions and underlying mechanisms remain unclear. This study aimed to fill these knowledge gaps. Quercetin, EGCG or their combination attenuated insulin resistance and decreased hepatic gluconeogenesis in high-fat-high-fructose diet (HFFD)-fed C57BL/6 mice and in palmitic acid (PA)-treated HepG2 cells. In mice, supplementation with quercetin (0.05%w/w), EGCG (0.05%w/w) and their combination (quercetin 0.05%+EGCG 0.05%w/w) reduced weight gain and fasting blood glucose and improved serum biochemical parameters. Compare with quercetin/EGCG alone, the quercetin-EGCG combination reduced gluconeogenesis to a greater extent via IRS-1/Akt/FOXO1-mediated down-regulation of downstream PEPCK and G-6-pase. In HepG2 cells, the quercetin (5 mu M)-EGCG (5 mu M) co-treatment exerted greater suppression on PAinduced changes in glucose and glycogen contents and hexokinase and G-6-pase activities than quercetin/ EGCG alone (each 10 mu M). The quercetin-EGCG co-treatment reduced glucose production through targeting FOXO1 and inhibiting the transcription of gluconeogenic enzymes. MiR-27a-3p and miR-96-5p regulated directly FOXO1 expression and function, and co-inhibition of miR-27a-3p and miR-96-5p weakened greatly the protective effect of quercetin-EGCG combination. This is the first report on the contributions of miR-27a-3p and miR-96-5p to the synergistic and protective effect of the quercetin-EGCG co-treatment against PA-induced insulin resistance through inhibiting FOXO1 expression.
C1 [Liu, Hui; Guan, Hui; Tan, Xintong; Jiang, Yang; Li, Feng; Sun-Waterhouse, Dongxiao; Li, Dapeng] Shandong Agr Univ, Coll Food Sci & Engn, Key Lab Food Proc Technol & Qual Control, Shandong Higher Educ Inst, Tai An 271018, Shandong, Peoples R China.
   [Sun-Waterhouse, Dongxiao] Univ Auckland, Sch Chem Sci, Auckland, New Zealand.
C3 Shandong Agricultural University; University of Auckland
RP Jiang, Y; Li, DP (corresponding author), Shandong Agr Univ, Coll Food Sci & Engn, Key Lab Food Proc Technol & Qual Control, Shandong Higher Educ Inst, Tai An 271018, Shandong, Peoples R China.
EM jiangyangsdau@163.com; dpli73@sdau.edu.cn
RI li, dapeng/G-4166-2010; LI, feng/HIR-1703-2022
OI Li, Feng/0000-0003-0611-2735; Li, Dapeng/0000-0002-1816-3217
FU National Science Foundation of China [31972070, 31571836]; Shandong
   Agricultural Innovation Team [SDAIT-24-05]; Shandong Taishan Leading
   Talent Project [LJNY2015004]; Major Projects of agricultural application
   technology innovation in Shandong Province; Shandong "Double Tops"
   Program [SYT2017XTTD04]
FX The authors acknowledge the support of the National Science Foundation
   of China (31972070, 31571836), Shandong Agricultural Innovation Team
   (SDAIT-24-05), Shandong Taishan Leading Talent Project (LJNY2015004).
   the Major Projects of agricultural application technology innovation in
   Shandong Province (2018) and Shandong "Double Tops" Program
   (SYT2017XTTD04).
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NR 57
TC 49
Z9 52
U1 7
U2 76
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0891-5849
EI 1873-4596
J9 FREE RADICAL BIO MED
JI Free Radic. Biol. Med.
PD MAR
PY 2022
VL 181
BP 105
EP 117
DI 10.1016/j.freeradbiomed.2022.02.002
EA FEB 2022
PG 13
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA YW7TG
UT WOS:000753616700001
PM 35124182
DA 2025-06-11
ER

PT J
AU Yazdanpanah, MJ
   Vahabi-Amlashi, S
   Nematy, M
   Shaelaei, N
   Tafazzoli, Z
AF Yazdanpanah, Mohammad Javad
   Vahabi-Amlashi, Sadegh
   Nematy, Mohsen
   Shaelaei, Neda
   Tafazzoli, Zahra
TI Association of serum lipid profiles and dietary intakes of vitamin E and
   fiber with psoriasis severity
SO CASPIAN JOURNAL OF INTERNAL MEDICINE
LA English
DT Article
DE Psoriasis; FFQ; Lipid profile; Oxidative stress; BMI; PASI score
ID METABOLIC SYNDROME; FOOD; EPIDEMIOLOGY; PATHOGENESIS; GENDER; RISK; AGE
AB Background: Dyslipidemia has been reportedly associated with an increased risk of atherosclerosis among psoriatic patients. Dietary intake can be a key factor in the pathophysiology of psoriasis. Herein, we assessed serum lipid profile and dietary intake in psoriatic patients, in comparison with healthy subjects.
   Methods: In this case-control study, 45 psoriatic patients and 43 healthy controls were evaluated. We estimated the macm/micronutrient intakes and energy, using a food frequency questionnaire (FFQ). Anthropometric parameters and serum levels of triglyceride (TG), high-density lipoproteins (HDL), low-density lipoproteins (LDL), and very low-density lipoproteins were assessed. The case group was categorized by severity measured by PASI score (mild<10, moderate 10-20, severe >20). Diet plan 6.0 was used to analyze FFQs and data were analyzed in SPSS 16.0, with p<0.05 considered significant.
   Results: The case group had markedly higher body mass index (BMI), LDL, and cholesterol and significantly lower HDL compared with controls (p<0.05). Carbohydrate, energy, fat intakes were significantly higher in cases, while folate, fiber, and vitamin E intakes were significantly lower in the case group, compared with the control group (p<0.05). BMI, cholesterol, and triglyceride values and dietary intakes of fiber and vitamin E were significantly associated with severity of psoriasis (p<0.05).
   Conclusion: Serum lipid profile and dietary intake are substantially important in psoriasis severity. Therefore, close monitoring of lipid profile and BMI during admission and followup and dietary modification can improve the severity of psoriasis.
C1 [Yazdanpanah, Mohammad Javad; Vahabi-Amlashi, Sadegh; Tafazzoli, Zahra] Mashhad Univ Med Sci, Cutaneous Leishmaniasis Res Ctr, Mashhad, Razavi Khorasan, Iran.
   [Nematy, Mohsen] Mashhad Univ Med Sci, Dept Biochem & Nutr, Fac Med, Mashhad, Razavi Khorasan, Iran.
   [Shaelaei, Neda] Mashhad Univ Med Sci, Fac Med, Mashhad, Razavi Khorasan, Iran.
C3 Mashhad University of Medical Sciences; Mashhad University of Medical
   Sciences; Mashhad University of Medical Sciences
RP Tafazzoli, Z (corresponding author), Imam Reza Hosp, Dept Dermatol, Ibn E Sina St, Mashhad, Razavi Khorasan, Iran.
EM tafazzoliz951@gmail.com
RI Vahabi-Amlashi, Sadegh/AAG-2559-2020
FU Mashhad University of Medical Sciences [6958]
FX The authors appreciate the Vice Chancellery for Research for their
   support of this project. This research project was part thesis of Neda
   Shalaei and was supported by the Vice Chancellery for Research, Mashhad
   University of Medical Sciences (thesis number: 6958) .
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NR 28
TC 10
Z9 11
U1 2
U2 4
PU BABOL UNIV MEDICAL SCIENCES
PI BABOL
PA ENGLISH JOURNAL OFFICE, GANJ AFROOZ AVE, BABOL, 00000, IRAN
SN 2008-6164
EI 2008-6172
J9 CASP J INTERN MED
JI Casp. J. Intern. Med.
PY 2021
VL 12
IS 4
BP 606
EP 612
DI 10.22088/cjim.12.4.606
PG 7
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA WG7WR
UT WOS:000707205900014
PM 34820070
DA 2025-06-11
ER

PT J
AU Heshmati, J
   Sepidarkish, M
   Morvaridzadeh, M
   Farsi, F
   Tripathi, N
   Razavi, M
   Rezaeinejad, M
AF Heshmati, Javad
   Sepidarkish, Mahdi
   Morvaridzadeh, Mojgan
   Farsi, Farnaz
   Tripathi, Nishant
   Razavi, Maryam
   Rezaeinejad, Mahroo
TI The effect of cinnamon supplementation on glycemic control in women with
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SO JOURNAL OF FOOD BIOCHEMISTRY
LA English
DT Review
DE cinnamon; glycemic control; insulin resistance; polycystic ovary
   syndrome
ID INSULIN-RESISTANCE; METABOLIC SYNDROME; OXIDATIVE STRESS; BLOOD-GLUCOSE;
   EXTRACT; RECEPTOR; INFLAMMATION; BIOMARKERS; IMPACT
AB Several clinical trials have identified glycemic-lowering effects of cinnamon, while other studies have reported conflicting findings. A comprehensive systematic search on Embase, PubMed, Scopus, Web of Science, and Cochrane Library was conducted using defined keywords in any language through June 2020. Studies that compared the effect of cinnamon with placebo on insulin resistance (IR) indices, as the primary outcome, in women with polycystic ovary syndrome (PCOS) were considered eligible. Standard Mean difference (SMD) (with 95% confidence intervals) for endpoints were calculated using the random-effects model. Finally, five RCTs which met the criteria were included in the meta-analysis. After pooling data, cinnamon supplementation significantly reduced homeostatic model assessment for insulin resistance (HOMA-IR) scores in women with PCOS (SMD: -0.84, 95% CI: -1.52, -0.16, p = .010). Cinnamon supplementation likely improves certain IR markers in patients with PCOS.
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C1 [Heshmati, Javad; Morvaridzadeh, Mojgan] Kermanshah Univ Med Sci, Sch Nutr Sci & Food Technol, Dept Nutr Sci, Kermanshah, Iran.
   [Sepidarkish, Mahdi] Babol Univ Med Sci, Sch Publ Hlth, Dept Biostat & Epidemiol, Babol, Iran.
   [Farsi, Farnaz] Iran Univ Med Sci, Colorectal Res Ctr, Tehran, Iran.
   [Farsi, Farnaz] Iran Univ Med Sci, Sch Publ Hlth, Dept Nutr, Tehran, Iran.
   [Tripathi, Nishant] Univ Kentucky, Dept Med, Lexington, KY 40506 USA.
   [Razavi, Maryam] Zahedan Univ Med Sci, Sch Med, Dept Obstet & Gynecol, Pregnancy Hlth Res Ctr, Zahedan, Iran.
   [Rezaeinejad, Mahroo] Univ Tehran Med Sci, Imam Khomeini Hosp, Dept Obstet & Gynecol, Tehran, Iran.
C3 Kermanshah University of Medical Sciences; Babol University of Medical
   Sciences; Iran University of Medical Sciences; Iran University of
   Medical Sciences; University of Kentucky; Zahedan University of Medical
   Sciences; Tehran University of Medical Sciences
RP Rezaeinejad, M (corresponding author), Univ Tehran Med Sci, Imam Khomeini Hosp, Dept Obstet & Gynecol, Tehran, Iran.
EM mahroo.rezaeinejad1397@gmail.com
RI Tripathi, Nishant/L-8012-2019; Morvaridzadeh, Mojgan/GLU-6418-2022;
   Sepidarkish, Mahdi/N-6176-2019; heshmati, javad/H-6812-2019
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NR 37
TC 22
Z9 22
U1 3
U2 12
PU WILEY-HINDAWI
PI LONDON
PA ADAM HOUSE, 3RD FL, 1 FITZROY SQ, LONDON, WIT 5HE, ENGLAND
SN 0145-8884
EI 1745-4514
J9 J FOOD BIOCHEM
JI J. Food Biochem.
PD JAN
PY 2021
VL 45
IS 1
AR e13543
DI 10.1111/jfbc.13543
EA OCT 2020
PG 8
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA PV2NW
UT WOS:000583959200001
PM 33111340
OA gold
DA 2025-06-11
ER

PT J
AU Morris, AR
   Stanton, DL
   Roman, D
   Liu, AC
AF Morris, Andrew R.
   Stanton, Daniel L.
   Roman, Destino
   Liu, Andrew C.
TI Systems Level Understanding of Circadian Integration with Cell
   Physiology
SO JOURNAL OF MOLECULAR BIOLOGY
LA English
DT Review
DE circadian clock; systems biology; cell homeostasis; mTOR; NF-kappa B
ID NF-KAPPA-B; CLOCK GENE-EXPRESSION; POSTTRANSLATIONAL MODIFICATIONS;
   TRANSCRIPTIONAL ARCHITECTURE; INDIVIDUAL FIBROBLASTS; CORE COMPONENT;
   RHYTHMS; TIME; CRYPTOCHROME; REVEALS
AB The mammalian circadian clock regulates a wide variety of physiological and behavioral processes. In turn, its disruption is associated with sleep deficiency, metabolic syndrome, neurological and psychiatric disorders, and cancer. At the turn of the century, the circadian clock was determined to be regulated by a transcriptional negative feedback mechanism composed of a dozen core clock genes. More recently, large-scale genomic studies have expanded the clock into a complex network composed of thousands of gene outputs and inputs. A major task of circadian research is to utilize systems biological approaches to uncover the governing principles underlying cellular oscillatory behavior and advance understanding of biological functions at the genomic level with spatiotemporal resolution. This review focuses on the genes and pathways that provide inputs to the circadian clock. Several emerging examples include AMP-activated protein kinase AMPK, nutrient/energy sensor mTOR, NAD(+)-dependent deacetylase SIRT1, hypoxia-inducible factor HIF1 alpha, oxidative stress-inducible factor NRF2, and the proinflammatory factor NF-kappa B. Among others that continue to be revealed, these input pathways reflect the extensive interplay between the clock and cell physiology through the regulation of core clock genes and proteins. While the scope of this crosstalk is well-recognized, precise molecular links are scarce, and the underlying regulatory mechanisms are not well understood. Future research must leverage genetic and genomic tools and technologies, network analysis, and computational modeling to characterize additional modifiers and input pathways. This systems-based framework promises to advance understanding of the circadian timekeeping system and may enable the enhancement of circadian functions through related input pathways. (C) 2020 Elsevier Ltd. All rights reserved.
C1 [Morris, Andrew R.; Roman, Destino; Liu, Andrew C.] Univ Florida, Dept Physiol & Funct Genom, Coll Med, Gainesville, FL 32610 USA.
   [Stanton, Daniel L.] Univ Florida, Dept Anim Sci, Inst Food & Agr Sci, Gainesville, FL 32610 USA.
C3 State University System of Florida; University of Florida; State
   University System of Florida; University of Florida
RP Liu, AC (corresponding author), Univ Florida, Dept Physiol & Funct Genom, Coll Med, Gainesville, FL 32610 USA.
EM andrew.liu@ufl.edu
RI Liu, Andrew/B-3548-2009; Stanton, Daniel/HPE-1932-2023; Morris,
   Andrew/ABD-8299-2020
OI Stanton, Daniel/0000-0003-3238-4523; Liu, Andrew
   Chuanyin/0000-0003-1927-0900; Morris, Andrew/0000-0002-4121-1467
FU National Science Foundation (NSF) Division of Integrative Organismal
   Systems (IOS) [1656647]; National Institutes of Health (NIH) National
   Institute of Neurological Disorders and Stroke (NINDS) [R01 NS054794];
   Division Of Integrative Organismal Systems; Direct For Biological
   Sciences [1656647] Funding Source: National Science Foundation
FX A.C.L. acknowledges funding from the National Science Foundation (NSF)
   Division of Integrative Organismal Systems (IOS) Award Number 1656647
   and the National Institutes of Health (NIH) National Institute of
   Neurological Disorders and Stroke (NINDS) R01 NS054794.
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NR 166
TC 24
Z9 25
U1 0
U2 16
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 0022-2836
EI 1089-8638
J9 J MOL BIOL
JI J. Mol. Biol.
PD MAY 29
PY 2020
VL 432
IS 12
BP 3547
EP 3564
DI 10.1016/j.jmb.2020.02.002
PG 18
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA MA5AH
UT WOS:000541925400009
PM 32061938
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Tepp, K
   Puurand, M
   Timohhina, N
   Aid-Vanakova, J
   Reile, I
   Shevchuk, I
   Chekulayev, V
   Eimre, M
   Peet, N
   Kadaja, L
   Paju, K
   Käämbre, T
AF Tepp, Kersti
   Puurand, Marju
   Timohhina, Natalja
   Aid-Vanakova, Jekaterina
   Reile, Indrek
   Shevchuk, Igor
   Chekulayev, Vladimir
   Eimre, Margus
   Peet, Nadada
   Kadaja, Lumme
   Paju, Kalju
   Kaambre, Tuuli
TI Adaptation of striated muscles to Wolframin deficiency in mice:
   Alterations in cellular bioenergetics
SO BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
LA English
DT Article
ID INTRACELLULAR ENERGETIC UNITS; ENDOPLASMIC-RETICULUM STRESS; OPTIC
   ATROPHY; WFS1 GENE; DIABETES-MELLITUS; MITOCHONDRIAL-FUNCTION;
   CREATINE-KINASE; MOLECULAR PARTNER; DIDMOAD SYNDROME; IN-SITU
AB Background: Wolfram syndrome (WS), caused by mutations in WFS1 gene, is a multi-targeting disease affecting multiple organ systems. Wolframin is localized in the membrane of the endoplasmic reticulum (ER), influencing Ca2+ metabolism and ER interaction with mitochondria, but the exact role of the protein remains unclear. In this study we aimed to characterize alterations in energy metabolism in the cardiac and in the oxidative and glycolytic skeletal muscles in Wfs1-deficiency.
   Methods: Alterations in the bioenergetic profiles in the cardiac and skeletal muscles of Wfs1-knock-out (KO) male mice and their wild type male littermates were determined using high resolution respirometry, quantitative RT-PCR, NMR spectroscopy, and immunofluorescence confocal microscopy.
   Results: Oxygen consumption without ATP synthase activation (leak) was significantly higher in the glycolytic muscles of Wfs1 KO mice compared to wild types. ADP-stimulated respiration with glutamate and malate was reduced in the Wfs1-deficient cardiac as well as oxidative and glycolytic skeletal muscles.
   Conclusions: Wfs1-deficiency in both cardiac and skeletal muscles results in functional alterations of energy transport from mitochondria to ATP-ases. There was a substrate-dependent decrease in the maximal Complex I -linked respiratory capacity of the electron transport system in muscles of Wfs1 KO mice. Moreover, in cardiac and gastrocnemius white muscles a decrease in the function of one pathway were balanced by the increase in the activity of the parallel pathway.
   General significance: This work provides new insights to the muscle involvement at early stages of metabolic syndrome like WS as well as developing glucose intolerance.
C1 [Tepp, Kersti; Puurand, Marju; Timohhina, Natalja; Aid-Vanakova, Jekaterina; Shevchuk, Igor; Chekulayev, Vladimir; Kaambre, Tuuli] NICPB, Lab Chem Biol, Akad Tee 23, EE-12618 Tallinn, Estonia.
   [Reile, Indrek] NICPB, Lab Chem Phys, Akad Tee 23, EE-12618 Tallinn, Estonia.
   [Eimre, Margus; Peet, Nadada; Kadaja, Lumme; Paju, Kalju] Univ Tartu, Inst Biomed & Translat Med, Dept Pathophysiol, Ravila 19, EE-50411 Tartu, Estonia.
C3 National Institute of Chemical Physics & Biophysics (NICPB); National
   Institute of Chemical Physics & Biophysics (NICPB); University of Tartu
RP Tepp, K (corresponding author), NICPB, Lab Chem Biol, Akad Tee 23, EE-12618 Tallinn, Estonia.
EM kersti.tepp@kbfi.ee
RI Reile, Indrek/G-6695-2016; Chekulayev, Vladimir/A-8382-2011;
   /G-9260-2019; Kaambre, Tuuli/A-9536-2008; Timohhina,
   Natalja/W-7959-2019; Tepp, Kersti/A-4829-2012; Puurand,
   Marju/E-5750-2016
OI Kaambre, Tuuli/0000-0001-5755-4694; Tepp, Kersti/0000-0001-7367-6632;
   Reile, Indrek/0000-0003-3278-7947; Puurand, Marju/0000-0002-0083-3390
FU Estonian Ministry of Education and Research [IUT23-1, IUT20-46];
   Mobilitas Pluss program of the Estonian Ministry of Education and
   Research [MOBTP51]; Center of Excellence of the Archimedes Foundation
   [TK134]; European Regional Development Fund [TK134]; European Union
   [668989]
FX This work was supported by Institutional Research Funding IUT23-1, and
   IUT20-46 of the Estonian Ministry of Education and Research, by
   Mobilitas Pluss program MOBTP51 of the Estonian Ministry of Education
   and Research; by Center of Excellence of the Archimedes Foundation and
   European Regional Development Fund Project No. TK134 and by the European
   Union's Horizon 2020 research and innovation program TRANSGENO project
   under grant agreement No. 668989.The authors thank Kadi Vaher for the
   proofreading.
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NR 75
TC 2
Z9 2
U1 1
U2 22
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29a, 1043 NX AMSTERDAM, NETHERLANDS
SN 0304-4165
EI 1872-8006
J9 BBA-GEN SUBJECTS
JI Biochim. Biophys. Acta-Gen. Subj.
PD APR
PY 2020
VL 1864
IS 4
AR 129523
DI 10.1016/j.bbagen.2020.129523
PG 12
WC Biochemistry & Molecular Biology; Biophysics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics
GA KT0FI
UT WOS:000518686000010
PM 31935437
OA Green Published
DA 2025-06-11
ER

PT J
AU Kim, JB
   Prunicki, M
   Haddad, F
   Dant, C
   Sampath, V
   Patel, R
   Smith, E
   Akdis, C
   Balmes, J
   Snyder, MP
   Wu, JC
   Nadeau, KC
AF Kim, Juyong Brian
   Prunicki, Mary
   Haddad, Francois
   Dant, Christopher
   Sampath, Vanitha
   Patel, Rushali
   Smith, Eric
   Akdis, Cezmi
   Balmes, John
   Snyder, Michael P.
   Wu, Joseph C.
   Nadeau, Kari C.
TI Cumulative Lifetime Burden of Cardiovascular Disease From Early Exposure
   to Air Pollution
SO JOURNAL OF THE AMERICAN HEART ASSOCIATION
LA English
DT Review
DE air pollutants; environmental; cardiovascular abnormalities;
   cardiovascular disease; epithelial barrier
ID EPITHELIAL BARRIER FUNCTION; LONG-TERM EXPOSURE; POLYCYCLIC
   AROMATIC-HYDROCARBONS; AMBIENT PARTICULATE MATTER; DIESEL EXHAUST
   PARTICLES; SYSTOLIC BLOOD-PRESSURE; INDUCE OXIDATIVE STRESS;
   PROINFLAMMATORY CYTOKINES; METABOLIC SYNDROME; TOBACCO-SMOKE
AB The disease burden associated with air pollution continues to grow. The World Health Organization (WHO) estimates approximate to 7 million people worldwide die yearly from exposure to polluted air, half of which-3.3 million-are attributable to cardiovascular disease (CVD), greater than from major modifiable CVD risks including smoking, hypertension, hyperlipidemia, and diabetes mellitus. This serious and growing health threat is attributed to increasing urbanization of the world's populations with consequent exposure to polluted air. Especially vulnerable are the elderly, patients with pre-existing CVD, and children. The cumulative lifetime burden in children is particularly of concern because their rapidly developing cardiopulmonary systems are more susceptible to damage and they spend more time outdoors and therefore inhale more pollutants. World Health Organization estimates that 93% of the world's children aged <15 years-1.8 billion children-breathe air that puts their health and development at risk. Here, we present growing scientific evidence, including from our own group, that chronic exposure to air pollution early in life is directly linked to development of major CVD risks, including obesity, hypertension, and metabolic disorders. In this review, we surveyed the literature for current knowledge of how pollution exposure early in life adversely impacts cardiovascular phenotypes, and lay the foundation for early intervention and other strategies that can help prevent this damage. We also discuss the need for better guidelines and additional research to validate exposure metrics and interventions that will ultimately help healthcare providers reduce the growing burden of CVD from pollution.
C1 [Kim, Juyong Brian; Haddad, Francois] Stanford Univ, Dept Med, Div Cardiovasc Med, Stanford, CA 94305 USA.
   [Kim, Juyong Brian; Prunicki, Mary; Dant, Christopher; Sampath, Vanitha; Patel, Rushali; Smith, Eric; Nadeau, Kari C.] Stanford Univ, Sean N Parker Ctr Allergy & Asthma Res, Stanford, CA 94305 USA.
   [Kim, Juyong Brian; Haddad, Francois; Wu, Joseph C.] Stanford Univ, Stanford Cardiovasc Inst, Stanford, CA 94305 USA.
   [Snyder, Michael P.] Stanford Univ, Dept Genet, Stanford, CA 94305 USA.
   [Snyder, Michael P.] Stanford Univ, Ctr Genom & Personalized Med, Stanford, CA 94305 USA.
   [Akdis, Cezmi] Univ Zurich, Swiss Inst Allergy & Asthma Res SIAF, Davos, Switzerland.
   [Balmes, John] Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA.
   [Balmes, John] Univ Calif Berkeley, Div Environm Hlth Sci, Sch Publ Hlth, Berkeley, CA 94720 USA.
C3 Stanford University; Stanford University; Stanford University; Stanford
   University; Stanford University; University of Zurich; Swiss Institute
   of Allergy & Asthma Research; University of California System;
   University of California San Francisco; University of California System;
   University of California Berkeley
RP Kim, JB (corresponding author), Falk CVRC, 300 Pasteur Dr, Stanford, CA 94305 USA.
EM kimjb@stanford.edu
RI Akdis, Cezmi/AAV-4844-2020; Balmes, John/L-6281-2019; Maier,
   Andrea/W-7060-2019; Stefanadis, Christodoulos/ABH-2232-2020; Wu,
   Joseph/H-1067-2013
OI Smith, Eric/0000-0002-1262-3112; Kim, Juyong/0000-0002-9675-2607;
   Stefanadis, Christodoulos/0000-0001-5974-6454; Wu,
   Joseph/0000-0002-6068-8041; Snyder, Michael/0000-0003-0784-7987; Akdis,
   Cezmi/0000-0001-8020-019X
FU National Institutes of Health [K08HL133375]; Tobacco-Related Disease
   Research Program [27IR-0012, T30IP0999]; Sean N Parker Center for
   Allergy and Asthma Research at Stanford University; National Institute
   of Environmental Health Sciences [R01ES020926, P01ES022849-05]; NHBLI
   [R01HL118612]
FX We received funding support from National Institutes of Health
   K08HL133375 (Kim), Tobacco-Related Disease Research Program T30IP0999
   (Kim), Tobacco-Related Disease Research Program 27IR-0012 (Wu), Sean N
   Parker Center for Allergy and Asthma Research at Stanford University
   (Nadeau, Dant, Smith, Prunicki, Patel), National Institute of
   Environmental Health Sciences P01ES022849-05 (Nadeau), NHBLI R01HL118612
   (Nadeau), National Institute of Environmental Health Sciences
   R01ES020926 (Nadeau).
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NR 222
TC 78
Z9 82
U1 0
U2 28
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
EI 2047-9980
J9 J AM HEART ASSOC
JI J. Am. Heart Assoc.
PD MAR 17
PY 2020
VL 9
IS 6
AR e014944
DI 10.1161/JAHA.119.014944
PG 20
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA KW7GX
UT WOS:000521353000002
PM 32174249
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Shojaee, A
   Parham, A
   Ejeian, F
   Esfahani, MHN
AF Shojaee, Asiyeh
   Parham, Abbas
   Ejeian, Fatemeh
   Esfahani, Mohammad Hossein Nasr
TI Equine adipose mesenchymal stem cells (eq-ASCs) appear to have higher
   potential for migration and musculoskeletal differentiation
SO RESEARCH IN VETERINARY SCIENCE
LA English
DT Article
DE Mesenchymal stem cells; Horse; Cell migration; Differentiation;
   Transforming growth factor beta 3
ID TGF-BETA; METABOLIC SYNDROME; OXIDATIVE STRESS; STROMAL CELLS; RECEPTOR;
   THERAPY; EXPRESSION; INHIBITOR; AUTOPHAGY
AB Equine adipose-derived mesenchymal stem cells (eq-ASCs) possess excellent regeneration potential especially for treatment of musculoskeletal disorders. Besides their common characteristics, MSCs harvested from different species reveal some species-specific and donor-dependent behaviors. Hence, the molecular analysis of MSCs may shed more light on their future clinical application of these cells. This study aimed to investigate some behavioral aspects of eq-ASCs in vitro which may influence the efficacy of stem cell therapy. For this purpose, MSCs of a donor horse were isolated, characterized and expanded under normal culture conditions. During continuous culture condition, eq-ASCs were started to formed aggregated structures that was accompanied with the up-regulation of migratory related genes including transforming growth factor beta 1 (TGFB1) and its receptor 3 (TGFBR3), and snail family transcriptional repressor 1 (SHA11), E-cadherin (CDH1) and beta-catenin (CTNNBI). Moreover, the expression of a musculoskeletal progenitor marker, scleraxis bHLH transcription factor (SCX), was also increased after 3 days. In order to clarify the impact of TGFB signaling pathway on cultured cells, gain- and loss-of-function treatment by TGFB3 and SB431542 (TGFB inhibitor) were performed, respectively. We found that TGFB3 treatment exaggerated the aggregate formation effects, in some extend via induction of cytoskeletal actin rearrangement, while inhibition of TGFB signaling pathway by SB431542 reversed this phenomenon. Overall, our findings support the fact that eq-ASCs have an inherent capacity for migration, which was enhanced by TGFB3 treatment and, this ability may play crucial role in cell motility and wound healing of transplanted cells.
C1 [Shojaee, Asiyeh; Parham, Abbas] Ferdowsi Univ Mashhad, Fac Vet Med, Dept Basic Sci, Div Physiol, Mashhad, Razavi Khorasan, Iran.
   [Parham, Abbas] Ferdowsi Univ Mashhad, Inst Biotechnol, Stem Cell Biol & Alternat Regenerat Med Grp, Mashhad, Razavi Khorasan, Iran.
   [Ejeian, Fatemeh; Esfahani, Mohammad Hossein Nasr] ACECR, Royan Inst Biotechnol, Dept Cellular Biotechnol, Cell Sci Res Ctr, Esfahan, Iran.
C3 Ferdowsi University Mashhad; Ferdowsi University Mashhad; Academic
   Center for Education, Culture & Research (ACECR)
RP Parham, A (corresponding author), Ferdowsi Univ Mashhad, Fac Vet Med, Dept Basic Sci, Div Physiol, Mashhad, Razavi Khorasan, Iran.; Esfahani, MHN (corresponding author), ACECR, Royan Inst Biotechnol, Dept Cellular Biotechnol, Cell Sci Res Ctr, Esfahan, Iran.
EM parham@um.ac.ir; mh.nasr-esfahani@royaninstitute.org
RI shojaee, asiyeh/AAI-9156-2021; Nasr-Esfahani, Mohammad/AAN-2577-2020;
   Ejeian, Fatemeh/ISU-2590-2023; Parham, Abbas/P-2200-2015
OI Parham, Abbas/0000-0003-4664-2917; Nasr-Esfahani,
   Mohammad-Hossein/0000-0003-1983-3435; shojaee,
   asiyeh/0000-0003-0808-1362; Ejeian, Fatemeh/0000-0002-4408-7588
FU Ferdowsi University of Mashhad; Royan institute, Iran; Iran National
   Science Foundation, Iran
FX The author thanks Dr. Nekokar for preparing horses sample. The author
   also thanks all members of Cell Science Research Center in Royan
   Institute of Biotechnology. This study was financially supported by
   Ferdowsi University of Mashhad, and Royan institute, and Iran National
   Science Foundation, Iran.
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NR 58
TC 6
Z9 7
U1 0
U2 0
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0034-5288
EI 1532-2661
J9 RES VET SCI
JI Res. Vet. Sci.
PD AUG
PY 2019
VL 125
BP 235
EP 243
DI 10.1016/j.rvsc.2019.06.015
PG 9
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA IW0IN
UT WOS:000484645700033
PM 31310927
DA 2025-06-11
ER

PT J
AU Bugatto, F
   Quintero-Prado, R
   Visiedo, FM
   Vilar-Sánchez, JM
   Figueroa-Quiñones, A
   López-Tinoco, C
   Torrejón, R
   Bartha, JL
AF Bugatto, Fernando
   Quintero-Prado, Rocio
   Visiedo, Francisco M.
   Vilar-Sanchez, Jose M.
   Figueroa-Quinones, Alejandro
   Lopez-Tinoco, Cristina
   Torrejon, Rafael
   Bartha, Jose L.
TI The Influence of Lipid and Proinflammatory Status on Maternal Uterine
   Blood Flow in Women With Late Onset Gestational Diabetes
SO REPRODUCTIVE SCIENCES
LA English
DT Article
DE gestational diabetes; cytokines; endothelial dysfunction; inflammation;
   uterine artery Doppler
ID CARDIOVASCULAR RISK; METABOLIC SYNDROME; ENDOTHELIAL DYSFUNCTION;
   OXIDATIVE STRESS; PREGNANCY; INFLAMMATION; DOPPLER
AB Background: Gestational diabetes mellitus (GDM) is associated with increased proinflammatory cytokines and is also associated with adverse cardiovascular disease (CVD) outcomes later in life. We aim to evaluate the relationships between uterine arteries vascularization and endothelial dysfunction markers, proinflammatory cytokines, and glycemic and lipid profile in women with GDM.
   Methods: Fifty pregnant women were recruited at the third trimester of pregnancy for a prospective cohort study. They were classified into 2 groups: control and GDM. Comparisons of maternal plasma concentrations of endothelial dysfunction markers (vascular cell adhesion molecule 1, intercellular adhesion molecule 1, and plasminogen activator inhibitor 1), proinflammatory cytokines and mediators (interleukin 6 [IL-6], tumor necrosis factor , vascular endothelial growth factor, placental growth factor, leptin, leukocyte count, and C-reactive protein), lipid profile, glucose, and glycosylated hemoglobin levels were performed. Mean uterine arteries Doppler pulsatility index (PI) was calculated and the relationships between the variables and PI were also analyzed.
   Results: Women with GDM showed higher proinflammatory cytokines, however, endothelial dysfunction markers were similar in both groups. In the diabetic group, significant correlations were found between the mean uterine arteries PI and maternal IL-6 (r = .56, P = .01), triglycerides (r = .49; P = .03), total cholesterol/high-density lipoprotein cholesterol (HDL-c) ratio (r = .61; P = .006), glucose (r = .62, P = .005), and glycosylated hemoglobin (r = .48; P = .03). A negative significant correlation between mean uterine arteries PI and HDLc (r = -.58; P = .02) was also found.
   Conclusion: The proinflammatory status, hyperlipidemia, and metabolic control correlate with uterine blood flow velocity waveforms in women with gestational diabetes.
C1 [Bugatto, Fernando; Vilar-Sanchez, Jose M.; Figueroa-Quinones, Alejandro; Torrejon, Rafael] Puerta del Mar Univ Hosp, Div Maternal Fetal Med, Dept Obstet & Gynecol, Avda Ana de Viya 21, Cadiz 11009, Spain.
   [Quintero-Prado, Rocio] Clin Ginemed, Seville, Spain.
   [Quintero-Prado, Rocio] Hosp de Jerez Univ Hosp, Dept Obstet & Gynecol, Cadiz, Spain.
   [Visiedo, Francisco M.] Puerta del Mar Univ Hosp, Res Unit, Cadiz, Spain.
   [Lopez-Tinoco, Cristina] Puerta del Mar Univ Hosp, Dept Endocrinol & Nutr, Cadiz, Spain.
   [Bartha, Jose L.] La Paz Univ Hosp, Div Maternal Fetal Med, Dept Obstet, Madrid, Spain.
C3 Universidad de Cadiz; Hospital Universitario Puerta del Mar; Universidad
   de Cadiz; Hospital Universitario Puerta del Mar; Universidad de Cadiz;
   Hospital Universitario Puerta del Mar; Hospital Universitario La Paz
RP Bugatto, F (corresponding author), Puerta del Mar Univ Hosp, Div Maternal Fetal Med, Dept Obstet & Gynecol, Avda Ana de Viya 21, Cadiz 11009, Spain.
EM fgbugatto@yahoo.com
RI Lopez-Tinoco, Cristina/K-5420-2019; Visiedo, Francisco/T-5048-2019;
   Prado, Rocío/AAT-3965-2020; Bartha, Jose/G-5401-2010; Visiedo Garcia,
   Francisco/M-3712-2014; Bugatto, Fernando/AAT-3389-2020
OI Visiedo Garcia, Francisco/0000-0001-7834-0169; QUINTERO PRADO,
   ROCIO/0000-0003-2824-8342; Bugatto, Fernando/0000-0001-9367-6541
FU Carlos III Health Institute (Spanish Ministry of Health) [PI11/00676];
   Consejeria de Salud, Junta de Andalucia [PI-0794-2010]
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: This study
   was supported by a grant from the Carlos III Health Institute (Spanish
   Ministry of Health, FIS grant PI11/00676) and grant from the Consejeria
   de Salud, Junta de Andalucia (PI-0794-2010) to FB.
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NR 25
TC 19
Z9 21
U1 0
U2 15
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1933-7191
EI 1933-7205
J9 REPROD SCI
JI Reprod. Sci.
PD JUN
PY 2018
VL 25
IS 6
BP 837
EP 843
DI 10.1177/1933719117698576
PG 7
WC Obstetrics & Gynecology; Reproductive Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology; Reproductive Biology
GA GL6TP
UT WOS:000437325000005
PM 28301988
DA 2025-06-11
ER

PT J
AU Escudero-López, B
   Ortega, A
   Cerrillo, I
   Rodríguez-Griñolo, MR
   Muñoz-Hernández, R
   Macher, HC
   Martín, F
   Hornero-Méndez, D
   Mena, P
   Del Rio, D
   Fernández-Pachón, MS
AF Escudero-Lopez, Blanca
   Ortega, Angeles
   Cerrillo, Isabel
   Rodriguez-Grinolo, Maria-Rosario
   Munoz-Hernandez, Rocio
   Macher, Hada C.
   Martin, Franz
   Hornero-Mendez, Damaso
   Mena, Pedro
   Del Rio, Daniele
   Fernandez-Pachon, Maria-Soledad
TI Consumption of orange fermented beverage improves antioxidant status and
   reduces peroxidation lipid and inflammatory markers in healthy humans
SO JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
LA English
DT Article
DE orange fermented beverage; bioactive compounds; antioxidant status;
   lipid peroxidation; inflammation status; healthy humans
ID CORONARY-ARTERY-DISEASE; C-REACTIVE PROTEIN; PLASMA VITAMIN-C; JUICE
   CONSUMPTION; METABOLIC SYNDROME; OXIDATIVE STRESS; RISK-FACTORS;
   ENDOTHELIAL MICROPARTICLES; ALCOHOLIC FERMENTATION; CARDIOVASCULAR RISK
AB BACKGROUNDAlcoholic fermentation of fruits has generated novel products with high concentrations of bioactive compounds and moderate alcohol content. The aim of this study was to evaluate the potential effect on cardiovascular risk factors of the regular consumption by healthy humans of a beverage obtained by alcoholic fermentation and pasteurization of orange juice.
   RESULTSThirty healthy volunteers were enrolled in a randomized controlled study. The experimental group (n=15) drank 500mL orange beverage (OB) per day for 2weeks (intervention phase), followed by a 3-week washout phase. Blood samples were collected at baseline (E-T0) and at the end of the intervention (E-T1) and washout (E-T2) phases. Controls (n=15) did not consume OB during a 2-week period. OB intake significantly increased oxygen radical absorbance capacity (43.9%) and reduced uric acid (-8.9%), catalase (CAT) (-23.2%), thiobarbituric acid reactive substances (TBARS) (-30.2%) and C-reactive protein (-2.1%) (E-T1 vs. E-T0). These effects may represent longer-term benefits, given the decreased uric acid (-8.9%), CAT (-34.6%), TBARS (-48.4%) and oxidized low-density lipoprotein (-23.9%) values recorded after the washout phase (E-T2 vs. E-T0).
   CONCLUSIONThe regular consumption of OB improved antioxidant status and decreased inflammation state, lipid peroxidation and uric acid levels. Thus OB may protect the cardiovascular system in healthy humans and be considered a novel functional beverage. (c) 2017 Society of Chemical Industry
C1 [Escudero-Lopez, Blanca; Ortega, Angeles; Cerrillo, Isabel; Martin, Franz; Fernandez-Pachon, Maria-Soledad] Univ Pablo de Olavide, Dept Biol Mol & Ingn Bioquim, Area Nutr & Bromatol, Seville, Spain.
   [Ortega, Angeles; Martin, Franz] Univ Pablo de Olavide, CIBER Diabet & Enfermedades Metab Asociadas CIBER, Seville, Spain.
   [Cerrillo, Isabel; Fernandez-Pachon, Maria-Soledad] Univ Autonoma Chile, Fac Ciencias Salud, Santiago, Chile.
   [Rodriguez-Grinolo, Maria-Rosario] Univ Pablo de Olavide, Dept Econ Metodos Cuantitativos Hist & Econ, Area Estadist & IO, Seville, Spain.
   [Munoz-Hernandez, Rocio] Univ Seville, CSIC, Hosp Univ Virgen del Rocio, Inst Biomed Sevilla IBiS,Lab Hipertens Arterial &, Seville, Spain.
   [Macher, Hada C.] Hosp Virgen del Rocio, Serv Bioquim Clin, Seville, Spain.
   [Hornero-Mendez, Damaso] CSIC, Inst Grasa, Dept Fitoquim Alimentos, Seville, Spain.
   [Mena, Pedro; Del Rio, Daniele] Univ Parma, Dept Food & Drug, Human Nutr Unit, Parma, Italy.
C3 Universidad Pablo de Olavide; CIBER - Centro de Investigacion Biomedica
   en Red; CIBERES; Universidad Pablo de Olavide; Universidad Autonoma de
   Chile; Universidad Pablo de Olavide; Virgen del Rocio University
   Hospital; Consejo Superior de Investigaciones Cientificas (CSIC);
   University of Sevilla; CSIC-JA-USE - Instituto de Biomedicina de Sevilla
   (IBIS); Virgen del Rocio University Hospital; Consejo Superior de
   Investigaciones Cientificas (CSIC); CSIC - Instituto de la Grasa (IG);
   University of Parma
RP Fernández-Pachón, MS (corresponding author), Univ Pablo de Olavide, Dept Biol Mol & Ingn Bioquim, Area Nutr & Bromatol, Seville, Spain.
EM msferpac@upo.es
RI Fernández-Pachón, María-Soledad/GOE-5442-2022; Hornero-Mendez,
   Damaso/H-2507-2012; Ortega, Angeles/ABA-8118-2020; Munoz-Hernandez,
   Rocio/S-5360-2016; Del Rio, Daniele/E-8696-2010; Cerrillo Garcia,
   Isabel/K-1455-2016; Martin, Franz/K-4197-2014; Escudero-Lopez,
   Blanca/ABG-3957-2020; Mena, Pedro/P-6353-2019; Rodriguez-Grinolo,
   Rosario/M-2453-2014
OI Munoz-Hernandez, Rocio/0000-0003-3765-6276; Del Rio,
   Daniele/0000-0001-5394-1259; Cerrillo Garcia,
   Isabel/0000-0001-9068-8176; Martin, Franz/0000-0002-5745-8704; Ortega de
   la Torre, Maria de los Angeles/0000-0002-0503-5793; Fernandez-Pachon,
   Maria-Soledad/0000-0002-9524-298X; Escudero-Lopez,
   Blanca/0000-0002-4964-1306; Mena, Pedro/0000-0003-2150-2977;
   Rodriguez-Grinolo, Rosario/0000-0002-3312-0848; Macher,
   Hada/0000-0002-8622-1175
FU Junta de Andalucia [P09-AGR4814M]; Grupo PAI [BIO311]
FX The authors are grateful for the support of the Junta de Andalucia
   through Projects P09-AGR4814M and Grupo PAI BIO311. They also thank
   Doctor Jose Villar (deceased) for clinical assistance in the laboratory
   of Virgen del Rocio Hospital, Grupo Hesperides Biotech SL for providing
   the orange beverage, and Richard Davies for editorial assistance.
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NR 74
TC 25
Z9 25
U1 2
U2 53
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-5142
EI 1097-0010
J9 J SCI FOOD AGR
JI J. Sci. Food Agric.
PD MAY
PY 2018
VL 98
IS 7
BP 2777
EP 2786
DI 10.1002/jsfa.8774
PG 10
WC Agriculture, Multidisciplinary; Chemistry, Applied; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture; Chemistry; Food Science & Technology
GA GC1TM
UT WOS:000429565000037
PM 29124773
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Dallio, M
   Masarone, M
   Errico, S
   Gravina, AG
   Nicolucci, C
   Di Sarno, R
   Gionti, L
   Tuccillo, C
   Persico, M
   Stiuso, P
   Diano, N
   Loguercio, C
   Federico, A
AF Dallio, M.
   Masarone, M.
   Errico, S.
   Gravina, A. G.
   Nicolucci, C.
   Di Sarno, R.
   Gionti, L.
   Tuccillo, C.
   Persico, M.
   Stiuso, P.
   Diano, N.
   Loguercio, C.
   Federico, A.
TI Role of bisphenol A as environmental factor in the promotion of
   non-alcoholic fatty liver disease: in vitro and clinical study
SO ALIMENTARY PHARMACOLOGY & THERAPEUTICS
LA English
DT Article
ID METABOLIC SYNDROME; HUMAN EXPOSURE; EPIDEMIOLOGY; URINARY;
   QUANTIFICATION; ACCUMULATION; MECHANISMS; STEATOSIS
AB Background: Bisphenol A is an endocrine disrupting chemical associated with type 2 diabetes mellitus (T2DM), cardiovascular disease and liver enzyme abnormalities.
   Aim: To evaluate bisphenol A plasma and urine levels in non-alcoholic fatty liver disease (NAFLD) patients compared to healthy subjects. Furthermore, we evaluated, in human HepG2 cells, the effects of exposure to different concentrations of bisphenol A on both oxidative stress induction and cell proliferation.
   Methods: We enrolled 60 patients with histological diagnosis of NAFLD with or without T2DM and sixty healthy subjects. In vitro, the proliferation of bisphenol A-exposed HepG2 cells at two different concentrations (0.025 and 0.05 mu M) was evaluated, both at high (H-HepG2) and at low (L-HepG2) glucose concentrations for 48h. Lipoperoxidation was assessed by thiobarbituric acid reactive substances (TBARS) assay.
   Results: Bisphenol A levels were significantly higher in 60 NAFLD subjects, both in urine and in plasma (P<0.0001) when compared to controls and, in this group, it appeared to be higher in 30 non-alcoholic steatohepatitis patients compared to 30 simple steatosis subjects (P<0.05), independently from the presence of T2DM. After a bisphenol A-free diet for 1 month, NAFLD patients showed a significant reduction in bisphenol A circulating levels (P<0.05), without a significant reduction in urine levels. H-HepG2 cells treated with bisphenol A (0.05 mu M) increased proliferation compared to controls at 48h (P<0.0001). Bisphenol A increased TBARS levels at 48h versus controls.
   Conclusions: Our study reveals a possible role of bisphenol A as an environmental factor involved in the promotion of NAFLD, particularly in T2DM patients.
C1 [Dallio, M.; Gravina, A. G.; Di Sarno, R.; Gionti, L.; Tuccillo, C.; Loguercio, C.; Federico, A.] Univ Campania Luigi Vanvitelli, Dept Clin & Expt Med, Naples, Italy.
   [Masarone, M.; Persico, M.] Univ Salerno, Dept Med & Surg, Salerno, Italy.
   [Errico, S.; Nicolucci, C.; Diano, N.] Univ Campania Luigi Vanvitelli, Dept Expt Med, Naples, Italy.
   [Stiuso, P.] Univ Campania Luigi Vanvitelli, Dept Biochem Biophys & Gen Pathol, Naples, Italy.
C3 Universita della Campania Vanvitelli; University of Salerno; Universita
   della Campania Vanvitelli; Universita della Campania Vanvitelli
RP Federico, A (corresponding author), Univ Campania Luigi Vanvitelli, Dept Clin & Expt Med, Naples, Italy.
EM alessandro.federico@unicampania.it
RI Federico, Alessandro/AAB-3893-2019; persico, marcello/AAB-3562-2019;
   Dallio, Marcello/ABG-7693-2020; Diano, Nadia/AAS-7358-2021; Gravina,
   Antonietta Gerarda/AAC-1528-2019; Masarone, Mario/H-8633-2017
OI DALLIO, MARCELLO/0000-0003-4153-815X; Gravina, Antonietta
   Gerarda/0000-0001-8049-0115; Diano, Nadia/0000-0003-4433-2667; Masarone,
   Mario/0000-0003-0550-8201; Federico, Alessandro/0000-0002-0885-0793;
   Persico, Marcello/0000-0002-1399-6498
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NR 47
TC 52
Z9 53
U1 5
U2 47
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0269-2813
EI 1365-2036
J9 ALIMENT PHARM THER
JI Aliment. Pharmacol. Ther.
PD MAR
PY 2018
VL 47
IS 6
BP 826
EP 837
DI 10.1111/apt.14499
PG 12
WC Gastroenterology & Hepatology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Pharmacology & Pharmacy
GA FW2EN
UT WOS:000425115500013
PM 29322544
OA Bronze
DA 2025-06-11
ER

PT J
AU Farinha, JB
   Krause, M
   Rodrigues-Krause, J
   Reischak-Oliveira, A
AF Farinha, Juliano Boufleur
   Krause, Mauricio
   Rodrigues-Krause, Josianne
   Reischak-Oliveira, Alvaro
TI Exercise for type 1 diabetes mellitus management: General considerations
   and new directions
SO MEDICAL HYPOTHESES
LA English
DT Article
ID INTERMITTENT HIGH-INTENSITY; RESISTANCE EXERCISE; AEROBIC EXERCISE;
   INSULIN-RESISTANCE; HORMONAL RESPONSES; SKELETAL-MUSCLE; METABOLIC
   SYNDROME; MODERATE EXERCISE; PHYSICAL-ACTIVITY; GLYCEMIC CONTROL
AB Type 1 diabetes mellitus (T1DM) is characterized by the loss of insulin secreting cells due to a directed autoimmune process, which is linked to oxidative stress and inflammation. Exercise training is known to induce several benefits by reducing inflammation and improving antioxidant defenses. In this context, exercise training may be considered as an efficient and relatively inexpensive non-pharmacological tool for diabetes treatment, added to the usual insulin administration. Unfortunately, most people with T1DM do not reach the recommended levels of physical activity due to concerns with hypoglycemic episodes. Recent data have demonstrated that exercise sessions composed by strength exercises or high-intensity interval exercise reduce the risk of hypoglycemia during and after the physical effort, when compared with continuous aerobic exercise in insulin-dependent patients. However, no studies have tested the chronic effects of this combination of protocols on health-related markeis yet. Herein, we suggest a combination of hypertrophic strength exercises (3 sets at 8-RM) with a high-intensity interval protocol (10 x 60-s bouts at similar to 90% HRmax interspersed with 60 s recovery) in the same exercise session, three times per week, for T1DM patients free of micro and macrovascular complications. Our hypothesis is that this training protocol may minimize the exercise-associated rapid drop of glucose levels in Tl DM, due to glucoregulatory hormones and transient reduction of insulin-mediated glucose uptake. This training is also likely to cover long-term glycaemic, bioenergetic, neuromuscular and cardiorespiratory adaptations, implicating in improved health and decreased risk of micro and macro complications. (C) 2017 Elsevier Ltd. All rights reserved.
C1 [Farinha, Juliano Boufleur; Rodrigues-Krause, Josianne; Reischak-Oliveira, Alvaro] Univ Fed Rio Grande do Sul, Sch Phys Educ Physiotherapy & Dance, Felizardo St 750, BR-90690200 Porto Alegre, RS, Brazil.
   [Krause, Mauricio] Univ Fed Rio Grande do Sul, Inst Basic Hlth Sci, Dept Physiol, Porto Alegre, RS, Brazil.
C3 Universidade Federal do Rio Grande do Sul; Universidade Federal do Rio
   Grande do Sul
RP Farinha, JB (corresponding author), Univ Fed Rio Grande do Sul, Sch Phys Educ Physiotherapy & Dance, Felizardo St 750, BR-90690200 Porto Alegre, RS, Brazil.
EM jbfarinha@yahoo.com.br
RI Krause, Mauricio/AAF-1160-2019; Farinha, Juliano/HDN-8796-2022;
   Rodrigues-Krause, Josianne/K-4088-2014; Reischak-Oliveira,
   Alvaro/D-3278-2009
OI Boufleur Farinha, Juliano/0000-0003-4589-256X; Krause,
   Mauricio/0000-0001-9814-742X; Rodrigues-Krause,
   Josianne/0000-0002-9791-9325; Reischak-Oliveira,
   Alvaro/0000-0003-4590-2991
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NR 52
TC 36
Z9 41
U1 0
U2 20
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0306-9877
EI 1532-2777
J9 MED HYPOTHESES
JI Med. Hypotheses
PD JUL
PY 2017
VL 104
BP 147
EP 153
DI 10.1016/j.mehy.2017.05.033
PG 7
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA FB2KZ
UT WOS:000405974000033
PM 28673573
DA 2025-06-11
ER

PT J
AU Santos-López, JA
   Garcimartín, A
   López-Oliva, ME
   Bautista-Avila, M
   González-Muñoz, MJ
   Bastida, S
   Benedí, J
   Sánchez-Muniz, FJ
AF Arturo Santos-Lopez, Jorge
   Garcimartin, Alba
   Elvira Lopez-Oliva, Maria
   Bautista-Avila, Mirandeli
   Jose Gonzalez-Munoz, Maria
   Bastida, Sara
   Benedi, Juana
   Jose Sanchez-Muniz, Francisco
TI Chia Oil- Enriched Restructured Pork Effects on Oxidative and
   Inflammatory Status of Aged Rats Fed High Cholesterol/ High Fat Diets
SO JOURNAL OF MEDICINAL FOOD
LA English
DT Article
DE ageing; antioxidant; cholesterol; inflammation; NASH; restructured pork
ID CARDIOVASCULAR RISK-FACTORS; LINOLENIC ACID ALA; ADIPOSE-TISSUE;
   METABOLIC SYNDROME; LIPID-METABOLISM; LIVER OXIDATION; MEAT-PRODUCTS;
   RICH; HYDROXYTYROSOL; CONSUMPTION
AB Chia oil has the highest recognized a-linolenic acid (ALA) content. ALA is associated with beneficial changes in plasma lipids and the prevention of cardiovascular diseases. Present article aims to analyze the effect of Chia oil-enriched restructured pork (RP) on aged rats in a nonalcoholic steatohepatitis (NASH) model. Groups of six male Wistar rats (1-year old) were fed the experimental diets: control RP diet (C) noncholesterol high saturated; cholesterol-enriched high-saturated fat/high-cholesterol control RP diet (HC) with added cholesterol and cholic acid; and Chia oil-or Hydroxytyrosol RP cholesterol-enriched high-saturated fat/high cholesterol (CHIA and HxT). Total cholesterol, hepatosomatic index, Nrf2, antioxidant, and inflammation markers were determined. CHIA reduced the hypercholesterolemic effect by lowering levels similar to C; also, ameliorated redox index. CHIA, despite high polyunsaturated fatty acids (PUFA) content, reduced thiobarbituric acid reactive substances (TBARS) and induced the lowest SOD protein synthesis but not a reduction on its activity. Chia oil activated the Nrf2 to arrest the pro-oxidative response to cholesterol and aging. Endothelial nitric oxide synthase (eNOS) system was lower in HxT than in CHIA, suggesting its antiatherogenic activity and related protective effect against high PUFA. Increase in tumor necrosis factor alpha (TNFa) was partially blocked by CHIA. Chia oil has the ability to prevent oxidative damage and modify the inflammatory response, suggesting adequate regulation of the antioxidant system. Results stress the importance of incorporating ALA into the diet.
C1 [Arturo Santos-Lopez, Jorge; Benedi, Juana] Univ Complutense Madrid, Pharm Sch, Pharmacol Dept, Madrid, Spain.
   [Garcimartin, Alba; Bastida, Sara; Jose Sanchez-Muniz, Francisco] Univ Complutense Madrid, Pharm Sch, Nutr & Food Sci Dept Nutr 1, Madrid, Spain.
   [Elvira Lopez-Oliva, Maria] Univ Complutense Madrid, Pharm Sch, Dept Sect Physiol, Madrid, Spain.
   [Bautista-Avila, Mirandeli] Autonomous Hidalgo State Univ, Acad Pharm Area, Hidalgo, Mexico.
   [Jose Gonzalez-Munoz, Maria] Alcala Univ, Pharm Sch, Biomed Sci Dept, Toxicol Teaching Unit, Alcala De Henares, Spain.
C3 Complutense University of Madrid; Complutense University of Madrid;
   Complutense University of Madrid; Universidad Autonoma del Estado de
   Hidalgo; Universidad de Alcala
RP Benedí, J (corresponding author), Univ Complutense Madrid, Dept Farmacol, Fac Farm, Plaza Ramon y Cajal S-N, E-28040 Madrid, Spain.; Sánchez-Muniz, FJ (corresponding author), Univ Complutense Madrid, Dept Nutr & Bromatol Nutr 1, Fac Farm, Plaza Ramon y Cajal S-N, E-28040 Madrid, Spain.
EM jbenedi@ucm.es; frasan@ucm.es
RI Bastida, Sara/L-1619-2014; Sanchez-Muniz, Francisco/K-9795-2014;
   López-Oliva, Elvira/L-1660-2014; Bautista, Mirandeli/AAJ-7399-2021;
   Santos-López, Jorge/L-5371-2019; Garcimartin, Alba/L-1223-2014
OI Santos-Lopez, Jorge Arturo/0000-0003-4924-0809; Garcimartin,
   Alba/0000-0002-6987-4203
FU CONACYT-Mexico [AGL 2014-53207-C2-2-R]
FX All authors have significantly contributed to the article and agree with
   the present version of the article. F.J.S.-M. and J.B. contributed to
   the study design, data discussion, and writing of the article. J.A.S.L.
   contributed to data acquisition and analysis and writing of the article.
   A.G. contributed to the data acquisition and analysis. M.B.-A.,
   M.J.G.-M., M.E.L.-O., S.B., and J.B. contributed to the data discussion
   and made a critical review of the article. The present study was
   supported by AGL 2014-53207-C2-2-R. J.A. S.-L. received the foreign PhD
   studies fellowship from CONACYT-Mexico.
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NR 57
TC 16
Z9 19
U1 0
U2 38
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1096-620X
EI 1557-7600
J9 J MED FOOD
JI J. Med. Food
PD MAY
PY 2017
VL 20
IS 5
BP 526
EP 534
DI 10.1089/jmf.2016.0161
PG 9
WC Chemistry, Medicinal; Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Food Science & Technology; Nutrition &
   Dietetics
GA EU7VZ
UT WOS:000401245300012
PM 28294699
DA 2025-06-11
ER

PT J
AU Ribeiro, RS
   Passos, CS
   Novaes, AS
   Maquigussa, E
   Glória, MA
   Visoná, I
   Ykuta, O
   Oyama, LM
   Boim, MA
AF Ribeiro, Rosemara S.
   Passos, Clevia S.
   Novaes, Antonio S.
   Maquigussa, Edgar
   Gloria, Maria A.
   Visona, Iria
   Ykuta, Olinda
   Oyama, Lila M.
   Boim, Mirian A.
TI Precocious obesity predisposes the development of more severe
   cisplatin-induced acute kidney injury in young adult mice
SO PLOS ONE
LA English
DT Article
ID MINERALOCORTICOID RECEPTOR; METABOLIC SYNDROME; DISEASE; ASSOCIATION;
   OVERWEIGHT; CANCER; RATS
AB Obesity and its consequences can damage the kidney over time. However, less is known about the impact of developing overweight/obesity during childhood on the kidney in adulthood and the renal impact of a superimposed acute kidney injury (AKI). This study evaluated the effect of obesity induced by a high-fat diet initiated soon after weaning on the adult life of mice and their response to superimposed nephrotoxic effects of cisplatin. C57BL/6 post weaning mice (3 weeks old) were divided into a control group (CT, n = 12) and a high-fat diet group (HF, n = 12). After 9 weeks, animals were further divided into the following groups: CT, CT treated with a single dose of cisplatin (CTCis, 20 mg/kg, i.p.), HF and HF treated with cisplatin (HFCis). The HF group exhibited higher body weight gain compatible with a moderate obesity. Obese mice presented increased visceral adiposity, hyperkalemia, sodium retention, glomerular hyperfiltration and proteinuria, without any significant changes in blood pressure and glycemia. AKI induced by cisplatin was exacerbated in obese animals with a 92% reduction in the GFR versus a 31% decrease in the CTCis group; this sharp decline resulted in severely elevated serum creatinine and urea levels. Acute tubular necrosis induced by cisplatin was worsened in obese mice. The HFCis group exhibited robust systemic and intrarenal inflammation that was significantly higher than that in the CTCis group; the HFCis group also showed a higher degree of renal oxidative stress. In conclusion, the moderate degree of obesity induced shortly after weaning resulted in mild early renal alterations, however, obese young animals were prone to develop a much more severe AKI induced by cisplatin.
C1 [Ribeiro, Rosemara S.; Passos, Clevia S.; Novaes, Antonio S.; Maquigussa, Edgar; Gloria, Maria A.; Ykuta, Olinda; Boim, Mirian A.] Univ Fed Sao Paulo, Dept Med, Div Renal, Sao Paulo, Brazil.
   [Visona, Iria] Univ Fed Sao Paulo, Dept Pathol, Sao Paulo, Brazil.
   [Oyama, Lila M.] Univ Fed Sao Paulo, Nutr Physiol, Dept Physiol, Sao Paulo, Brazil.
C3 Universidade Federal de Sao Paulo (UNIFESP); Universidade Federal de Sao
   Paulo (UNIFESP); Universidade Federal de Sao Paulo (UNIFESP)
RP Boim, MA (corresponding author), Univ Fed Sao Paulo, Dept Med, Div Renal, Sao Paulo, Brazil.
EM maboim@unifesp.br
RI Boim, Mirian/L-6574-2013; dos Santos Passos, Clevia/B-8463-2014; Oyama,
   Lila/B-7609-2012; Novaes, Antonio/A-5459-2017; Maquigussa,
   Edgar/G-7685-2016
OI Novaes, Antonio/0000-0002-8418-2504; Maquigussa,
   Edgar/0000-0003-1756-1579; A Boim, Mirian/0000-0001-7500-8371
FU Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
   [470662/2013-1]; Fundagao de Amparo a Pesquisa do Estado de Sao Paulo
   (FAPESP) to RSR; Coordenagao de Aperfeigoamento de Pessoal de Nivel
   superior (CAPES); Fundagao Oswaldo Ramos
FX This work was supported by Conselho Nacional de Desenvolvimento
   Cientifico e Tecnologico (CNPq), grant no 470662/2013-1 to MAB, by
   Fundagao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) to RSR, by
   Coordenagao de Aperfeigoamento de Pessoal de Nivel superior (CAPES), and
   by Fundagao Oswaldo Ramos. The funders had no role in study design, data
   collection and analysis, decision to publish, or preparation of the
   manuscript.
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NR 40
TC 11
Z9 11
U1 0
U2 4
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAR 30
PY 2017
VL 12
IS 3
AR e0174721
DI 10.1371/journal.pone.0174721
PG 17
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA ER9VI
UT WOS:000399174800078
PM 28358868
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Ray, I
   Mahata, SK
   De, RK
AF Ray, Indrani
   Mahata, Sushil K.
   De, Rajat K.
TI Obesity: An immunometabolic Perspective
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Review
DE obesity; insulin resistance; macrophages; ER stress; reactive oxygen
   species; type 2 diabetes; non-alcoholic fatty liver diseases
ID NECROSIS-FACTOR-ALPHA; INDUCED INSULIN-RESISTANCE; ADIPOSE-TISSUE
   FIBROSIS; HEPATIC STELLATE CELLS; NATURAL-KILLER-CELLS; FATTY
   LIVER-DISEASE; KUPFFER CELLS; MACROPHAGE INFILTRATION; METABOLIC
   SYNDROME; INNATE IMMUNITY
AB Obesity, characterized by chronic activation of inflammatory pathways, is a critical factor contributing to insulin resistance (IR) and type 2 diabetes (T2D). Free fatty acids (FFAs) are increased in obesity and are implicated as proximate causes of IR and induction of inflammatory signaling in adipose, liver, muscle, and pancreas. Cells of the innate immune system produce cytokines, and other factors that affect insulin signaling and result in the development of IR. In the lean state, adipose tissue is populated by adipose tissue macrophage of the anti-inflammatory M2 type (ATM2) and natural killer (NK) cells; this maintains the insulin-sensitive phenotype because ATM2 cells secrete IL10. In contrast, obesity induces lipolysis and release of pro-inflammatory FFAs and factors, such as chemokine (C-C motif) ligand 2 (CCL2) and tumor necrosis factor alpha (TNF-alpha), which recruit blood monocytes in adipose tissue, where they are converted to macrophages of the highly pro-inflammatory M1-type (ATM1). Activated ATM1 produce large amounts of pro-inflammatory mediators such as TNF-a, interleukin-1 beta, IL-6, leukotriene B4, nitric oxide (NO), and resistin that work in a paracrine fashion and cause IR in adipose tissue. In the liver, both pro-inflammatory Kupffer cells (M1-KCs) and recruited hepatic macrophages (Ly6C(high)) contribute to decreased hepatic insulin sensitivity. The present mini-review will update the bidirectional interaction between the immune system and obesity-induced changes in metabolism in adipose tissue and liver and the metabolic consequences thereof.
C1 [Ray, Indrani; De, Rajat K.] Indian Stat Inst, Machine Intelligence Unit, Kolkata, India.
   [Mahata, Sushil K.] VA San Diego Healthcare Syst, Metab Physiol & Ultrastruct Biol Lab, La Jolla, CA 92161 USA.
   [Mahata, Sushil K.] Univ Calif San Diego, Metab Physiol & Ultrastruct Biol Lab, La Jolla, CA 92093 USA.
C3 Indian Statistical Institute; Indian Statistical Institute Kolkata; US
   Department of Veterans Affairs; Veterans Health Administration (VHA); VA
   San Diego Healthcare System; University of California System; University
   of California San Diego
RP De, RK (corresponding author), Indian Stat Inst, Machine Intelligence Unit, Kolkata, India.; Mahata, SK (corresponding author), VA San Diego Healthcare Syst, Metab Physiol & Ultrastruct Biol Lab, La Jolla, CA 92161 USA.; Mahata, SK (corresponding author), Univ Calif San Diego, Metab Physiol & Ultrastruct Biol Lab, La Jolla, CA 92093 USA.
EM smahata@ucsd.edu; rajat@isical.ac.in
RI Mahata, Sushil/AAF-8781-2021
FU CSIR, India [09/093(0156)/2014-EMR-I]
FX The authors thank Sumana Mahata for editing the review article. Indrani
   Ray gratefully acknowledges CSIR, India, for providing her a Senior
   Research Fellowship (09/093(0156)/2014-EMR-I).
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NR 128
TC 73
Z9 81
U1 2
U2 42
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD DEC 12
PY 2016
VL 7
AR 157
DI 10.3389/fendo.2016.00157
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA EE4VQ
UT WOS:000389604000001
PM 28018292
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Zhou, ZX
   Chen, JK
   Hong, YY
   Zhou, R
   Zhou, DM
   Sun, LY
   Qin, WL
   Wang, TC
AF Zhou, Zhen-Xing
   Chen, Jian-Kui
   Hong, Yan-Ying
   Zhou, Ru
   Zhou, Dong-Mei
   Sun, Li-Yun
   Qin, Wen-Li
   Wang, Tian-Cheng
TI Relationship Between the Serum Total Bilirubin and Inflammation in
   Patients With Psoriasis Vulgaris
SO JOURNAL OF CLINICAL LABORATORY ANALYSIS
LA English
DT Article
DE psoriasis vulgaris; bilirubin; inflammation; CRP; logistic regression
ID C-REACTIVE PROTEIN; TO-SEVERE PSORIASIS; ACUTE MYOCARDIAL-INFARCTION;
   CORONARY-ARTERY-DISEASE; INTIMA MEDIA THICKNESS; CARDIOVASCULAR RISK;
   METABOLIC SYNDROME; OXIDATIVE STRESS; HEME OXYGENASE-1; KOREAN ADULTS
AB Background: Psoriasis is a chronic and recurrent inflammatory skin disease. Previous studies have shown that bilirubin has anti inflammation and antioxidant effects. However, the various roles of bilirubin in psoriasis patients are still unclear. Objective: To investigate the serum total bilirubin (TB) level in the individuals with psoriasis vulgaris and further evaluate the relationship between serum TB concentration and C reactive protein (CRP) to clarify the effect of bilirubin on inflammation. Methods: A total of 214 patients with psoriasis vulgaris and 165 age- and gender-matched healthy control subjects were recruited. The peripheral leukocyte count (white blood cell, WBC) and differential, serum biochemical and immunologic indexes including serum TB, immunoglobulin (Ig) G, IgA, IgM, complement C3 and C4, as well as serum CRP concentrations were measured. Results: Results showed that the serum TB level decreased significantly and peripheral WBC, neutrophil, and serum CRP concentrations increased significantly in patients with psoriasis vulgaris. Meanwhile, the serum CRP was negatively correlated with serum TB levels but positively correlated with peripheral WBC and the Psoriasis Area and Severity Index (PASO. Logistic regression analysis showed that the serum TB was a protective factor for psoriasis vulgaris. Conclusion: The present study suggests that lower serum TB is associated with the enhancement of the inflammatory response in psoriasis vulgaris. Therefore, lower serum TB has a prognostic significance for worsening psoriasis vulgaris. Bilirubin may play a crucial role in inflammation by contributing to the inhibition of the inflammatory response. J. Clin. Lab. Anal. 30:768-775, 2016. (C) 2016 Wiley Periodicals, Inc.
C1 [Zhou, Zhen-Xing; Hong, Yan-Ying] Capital Med Univ, Beijing Tradit Chinese Med Hosp, Dept Clin Lab, Beijing, Peoples R China.
   [Chen, Jian-Kui] Acad Mil Med Sci, Dept Clin Lab, Beijing, Peoples R China.
   [Zhou, Ru] Capital Med Univ, Beijing Ditan Hosp, Dept Clin Lab, Beijing, Peoples R China.
   [Zhou, Dong-Mei; Sun, Li-Yun] Capital Med Univ, Beijing Tradit Chinese Med Hosp, Dept Dermatol, Beijing, Peoples R China.
   [Qin, Wen-Li] Gen Hosp Beijing Mil Reg, Jingxi Hosp, Dept Clin Lab, Beijing, Peoples R China.
   [Wang, Tian-Cheng] Peking Univ, Hosp 3, Dept Clin Lab, 49 North Huayuan Rd, Beijing 100191, Peoples R China.
C3 Capital Medical University; Academy of Military Medical Sciences -
   China; Capital Medical University; Capital Medical University; Seventh
   Medical Center of Chinese PLA General Hospital; Peking University
RP Wang, TC (corresponding author), Peking Univ, Hosp 3, Dept Clin Lab, 49 North Huayuan Rd, Beijing 100191, Peoples R China.
EM tcwang@bjmu.edu.cn
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NR 43
TC 27
Z9 30
U1 0
U2 12
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 0887-8013
EI 1098-2825
J9 J CLIN LAB ANAL
JI J. Clin. Lab. Anal.
PD SEP
PY 2016
VL 30
IS 5
BP 768
EP 775
DI 10.1002/jcla.21936
PG 8
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA EA9AW
UT WOS:000386933600067
PM 27061381
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Rudrappa, SS
   Wilkinson, DJ
   Greenhaff, PL
   Smith, K
   Idris, I
   Atherton, PJ
AF Rudrappa, Supreeth S.
   Wilkinson, Daniel J.
   Greenhaff, Paul L.
   Smith, Kenneth
   Idris, Iskandar
   Atherton, Philip J.
TI Human Skeletal Muscle Disuse Atrophy: Effects on Muscle Protein
   Synthesis, Breakdown, and Insulin Resistance-A Qualitative Review
SO FRONTIERS IN PHYSIOLOGY
LA English
DT Review
DE skeletal muscle; disuse; immobilization; protein metabolism; diabetes
ID HUMAN QUADRICEPS MUSCLE; ESSENTIAL AMINO-ACIDS; SPINAL-CORD-INJURY; BED
   REST; OXIDATIVE STRESS; LEG IMMOBILIZATION; MOLECULAR-MECHANISMS;
   ANABOLIC RESISTANCE; UBIQUITIN LIGASES; GENE-EXPRESSION
AB The ever increasing burden of an aging population and pandemic of metabolic syndrome worldwide demands further understanding of the modifiable risk factors in reducing disability and morbidity associated with these conditions. Disuse skeletal muscle atrophy (sometimes referred to as "simple" atrophy) and insulin resistance are "non-pathological" events resulting from sedentary behavior and periods of enforced immobilization e.g., due to fractures or elective orthopedic surgery. Yet, the processes and drivers regulating disuse atrophy and insulin resistance and the associated molecular events remain unclear especially in humans. The aim of this review is to present current knowledge of relationships between muscle protein turnover, insulin resistance and muscle atrophy during disuse, principally in humans. Immobilization lowers fasted state muscle protein synthesis (MPS) and induces fed-state "anabolic resistance." While a lack of dynamic measurements of muscle protein breakdown (MPB) precludes defining a definitive role for MPB in disuse atrophy, some proteolytic "marker" studies (e.g., MPB genes) suggest a potential early elevation. Immobilization also induces muscle insulin resistance (IR). Moreover, the trajectory of muscle atrophy appears to be accelerated in persistent IR states (e.g., Type II diabetes), suggesting IR may contribute to muscle disuse atrophy under these conditions. Nonetheless, the role of differences in insulin sensitivity across distinct muscle groups and its effects on rates of atrophy remains unclear. Multifaceted time-course studies into the collective role of insulin resistance and muscle protein turnover in the setting of disuse muscle atrophy, in humans, are needed to facilitate the development of appropriate countermeasures and efficacious rehabilitation protocols.
C1 [Rudrappa, Supreeth S.; Wilkinson, Daniel J.; Greenhaff, Paul L.; Smith, Kenneth; Idris, Iskandar; Atherton, Philip J.] Univ Nottingham, Royal Derby Hosp, MRC Arthrit Res UK Ctr Musculoskeletal Ageing Res, Div Med Sci & Grad Entry Med,Sch Med, Derby, England.
C3 University of Nottingham
RP Idris, I; Atherton, PJ (corresponding author), Univ Nottingham, Royal Derby Hosp, MRC Arthrit Res UK Ctr Musculoskeletal Ageing Res, Div Med Sci & Grad Entry Med,Sch Med, Derby, England.
EM iskandar.idris@nottingham.ac.uk; philip.atherton@nottingham.ac.uk
RI Atherton, Paul/GLS-3029-2022; Rudrappa, Supreeth/AGG-8292-2022
OI Smith, Ken/0000-0001-8971-6635; Greenhaff, Paul/0000-0003-4403-0490;
   Shanthaveerappa Rudrappa, Supreeth/0000-0003-0822-5055; Atherton,
   Philip/0000-0002-7286-046X
FU University of Nottingham within the MRC-ARUK Centre for Musculoskeletal
   Ageing Research; Medical Research Council [MR/K00414X/1]; Arthritis
   Research UK [19891]; BBSRC [BB/G011435/1, BB/I020713/1, BB/K019104/1]
   Funding Source: UKRI; MRC [MR/K00414X/1] Funding Source: UKRI
FX The first author is a doctoral research student funded through the
   University of Nottingham within the MRC-ARUK Centre for Musculoskeletal
   Ageing Research. The MRC-ARUK Centre for Musculoskeletal Ageing Research
   was funded through grants from the Medical Research Council [grant
   number MR/K00414X/1] and Arthritis Research UK [grant number 19891]
   awarded to the Universities of Nottingham and Birmingham.
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NR 94
TC 130
Z9 142
U1 0
U2 34
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-042X
J9 FRONT PHYSIOL
JI Front. Physiol.
PD AUG 25
PY 2016
VL 7
AR 361
DI 10.3389/fphys.2016.00361
PG 10
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA DT9WG
UT WOS:000381852400001
PM 27610086
OA Green Published, gold, Green Accepted
DA 2025-06-11
ER

PT J
AU Saheblear, A
   Hernández-Aguilera, A
   Abelló, D
   Sancho, E
   Camps, J
   Joven, J
AF Saheblear, Amirhossein
   Hernandez-Aguilera, Anna
   Abello, David
   Sancho, Elena
   Camps, Jordi
   Joven, Jorge
TI Systematic review and meta-analysis deciphering the impact of fibrates
   on paraoxonase-1 status
SO METABOLISM-CLINICAL AND EXPERIMENTAL
LA English
DT Review
DE Cardiovascular risk; HDL; Hypertriglyceridemia; Lipoprotein metabolism;
   Oxidation
ID CHOLESTERYL ESTER TRANSFER; COMBINATION LIPID THERAPY; EXTENDED-RELEASE
   NIACIN; CORONARY-HEART-DISEASE; RECENT CLINICAL-TRIALS; LIFE-STYLE
   FACTORS; LOW HDL-C; CARDIOVASCULAR OUTCOMES; OXIDATIVE STRESS;
   PUBLICATION BIAS
AB Objective. A significant residual cardiovascular risk is consistently observed in patients treated with statins. A combined treatment with fibrates reduces cardiovascular events in very high-risk patients. Because this is apparently unconnected to an improvement in lipid related outcomes we hypothesized that the cardioprotective effects of fibrates might be associated with an improvement in paraoxonase-1 (PON1) status.
   Method. The search for existing evidence, using the Medline, Scopus and Cochrane databases, was systematic and followed the PRISMA statement without restrictions on publication date. We excluded non-clinical and observational studies and we extracted data on baseline and post-treatment values of serum PON1 activity and other measurements of PON1 status.
   Results. Nine studies (including 12 treatment arms) in patients with hyperlipidemia, diabetes or metabolic syndrome treated with fibrates, alone or in combination with statins, were included to synthesize results. A meta-analysis of the data using a random-effects model revealed a significant increase in serum PON1 activity following fibrate therapy (WMD: 15.64 U/L, 95% CI: 6.94, 24.34, p < 0.001), an effect that was robust and not sensitive to any particular study. Subgroup analysis indicated differences in the effect size among types of fibrates and that PON1 alterations were associated with high-density lipoprotein cholesterol changes following fibrate therapy.
   Conclusions. Results indicate a significant PON1-enhancing effect of fibrates. Whether this effect is associated with a clinical benefit, although likely, remains to be further investigated. (C) 2016 Elsevier Inc. All rights reserved.
C1 [Saheblear, Amirhossein] Mashhad Univ Med Sci, Biotechnol Res Ctr, Mashhad, Iran.
   [Saheblear, Amirhossein] Univ Western Australia, Metab Res Ctr, Sch Med & Pharmacol, Perth, WA 6009, Australia.
   [Hernandez-Aguilera, Anna; Abello, David; Sancho, Elena; Camps, Jordi; Joven, Jorge] Univ Rovira & Virgili, Hosp Univ St Joan, Inst Invest Sanitaria Pere Virgili, Unitat Recerca Biomed, Campus Int Excellence Southern Catalonia, Reus 43201, Spain.
C3 Mashhad University of Medical Sciences; University of Western Australia;
   Universitat Rovira i Virgili; Institut d'Investigacio Sanitaria Pere
   Virgili (IISPV)
RP Joven, J (corresponding author), Univ Rovira & Virgili, Hosp Univ St Joan, Inst Invest Sanitaria Pere Virgili, Unitat Recerca Biomed, Campus Int Excellence Southern Catalonia, Reus 43201, Spain.
EM jorge.joven@urv.cat
RI Camps, Jordi/AAG-3080-2020; Joven, Jorge/B-3360-2016
OI Joven, Jorge/0000-0003-2749-4541; Sancho, Elena/0000-0001-6522-6252;
   Hernandez-Aguilera, Anna/0000-0003-0954-295X
FU Carlos III Health Institute, Madrid, Spain; European Fund for Regional
   Development (FEDER) [PI15/00285]; Generalitat de Catalunya [14SGR1227]
FX Unitat de Recerca Biomedica is supported by a grant from the Carlos III
   Health Institute, Madrid, Spain and the European Fund for Regional
   Development (FEDER), no. PI15/00285 and also from Generalitat de
   Catalunya (14SGR1227).
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NR 105
TC 16
Z9 17
U1 0
U2 11
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0026-0495
EI 1532-8600
J9 METABOLISM
JI Metab.-Clin. Exp.
PD MAY
PY 2016
VL 65
IS 5
BP 609
EP 622
DI 10.1016/j.metabol.2016.01.002
PG 14
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA DK1ZI
UT WOS:000374714000002
PM 27085770
DA 2025-06-11
ER

PT J
AU Correia-Costa, L
   Sousa, T
   Morato, M
   Cosme, D
   Afonso, J
   Moura, C
   Mota, C
   Areias, JC
   Guerra, A
   Schaefer, F
   Afonso, AC
   Barros, H
   Albino-Teixeira, A
   Azevedo, A
AF Correia-Costa, Liane
   Sousa, Teresa
   Morato, Manuela
   Cosme, Dina
   Afonso, Joana
   Moura, Claudia
   Mota, Claudia
   Areias, Jose Carlos
   Guerra, Antonio
   Schaefer, Franz
   Afonso, Alberto Caldas
   Barros, Henrique
   Albino-Teixeira, Antonio
   Azevedo, Ana
TI Association of myeloperoxidase levels with cardiometabolic factors and
   renal function in prepubertal children
SO EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
LA English
DT Article
DE Blood pressure; childhood obesity; glomerular filtration rate;
   myeloperoxidase; pulse wave velocity
ID LOW-DENSITY-LIPOPROTEIN; BLOOD-PRESSURE; OXIDATIVE STRESS; ENDOTHELIAL
   DYSFUNCTION; CARDIOVASCULAR RISK; METABOLIC SYNDROME; OBESE CHILDREN;
   INFLAMMATION; HEALTH; INJURY
AB Introduction Myeloperoxidase (MPO), an enzyme linking obesity and cardiovascular (CV) risk in adults, has rarely been studied in young children and no studies assessed its association with renal function. We sought to explore a possible association between serum MPO levels, obesity, CV risk factors and renal function in prepubertal children.
   Materials/Methods Cross-sectional evaluation of 309 children aged 8-9 years (161 normal weight, 148 overweight/obese), members of the birth cohort Generation XXI (Portugal). Anthropometrics (body mass index (BMI), waist-to-height ratio (WHtR) and % body fat mass (% BFM) by bioelectrical impedance analysis), 24-h ambulatory blood pressure monitoring and pulse wave velocity (PWV) were measured. Insulin resistance was estimated by the HOMA index (considering serum fasting glucose and insulin determinations). Serum MPO levels were assessed by immunoenzymatic assay.
   Results MPO levels were positively associated with obesity indices (BMI z-score, WHtR and % BFM). Higher MPO levels were associated with higher 24-h and night-time mean arterial pressure, with nondipping and with higher values of insulin resistance. In normal weight children, the endothelial function, as evaluated indirectly by PWV, was an independent predictor of MPO levels. In overweight/obese children, estimated glomerular filtration rate increased significantly across tertiles of MPO (P-trend = 0.031) and this association held after adjustment for age, sex, neutrophil and monocyte counts and CV risk factors.
   Conclusions Our results reinforce the role of MPO as a risk marker in obesity and related CV morbidities in young children. MPO levels associate with the dipping pattern and PWV and, among overweight/obese children, an association exists between MPO and renal function.
C1 [Correia-Costa, Liane; Cosme, Dina; Afonso, Alberto Caldas; Barros, Henrique; Azevedo, Ana] Univ Porto, Inst Publ Hlth, EPIUnit, P-4050600 Oporto, Portugal.
   [Correia-Costa, Liane; Afonso, Alberto Caldas] Ctr Hosp Sao Joao, Integrated Pediat Hosp, Div Pediat Nephrol, Oporto, Portugal.
   [Sousa, Teresa; Morato, Manuela; Cosme, Dina; Afonso, Joana; Albino-Teixeira, Antonio] Univ Porto, Fac Med, Dept Pharmacol & Therapeut, P-4050600 Oporto, Portugal.
   [Sousa, Teresa; Morato, Manuela; Albino-Teixeira, Antonio] Univ Porto, MedInUP Ctr Drug Discovery & Innovat Med, P-4050600 Oporto, Portugal.
   [Morato, Manuela] Univ Porto, REQUIMTE, Fac Pharm Porto, Dept Drug Sci,Lab Pharmacol, P-4050600 Oporto, Portugal.
   [Moura, Claudia; Mota, Claudia; Areias, Jose Carlos] Ctr Hosp Sao Joao, Integrated Pediat Hosp, Div Pediat Cardiol, Oporto, Portugal.
   [Guerra, Antonio] Ctr Hosp Sao Joao, Integrated Pediat Hosp, Div Pediat Nutr, Oporto, Portugal.
   [Schaefer, Franz] Heidelberg Univ, Ctr Pediat & Adolescent Med, Div Pediat Nephrol, Heidelberg, Germany.
   [Barros, Henrique; Azevedo, Ana] Univ Porto, Fac Med, Dept Clin Epidemiol Predict Med & Publ Hlth, P-4050600 Oporto, Portugal.
C3 Universidade do Porto; Sao Joao Hospital; Universidade do Porto;
   Universidade do Porto; Universidade do Porto; Sao Joao Hospital; Sao
   Joao Hospital; Ruprecht Karls University Heidelberg; Universidade do
   Porto
RP Correia-Costa, L (corresponding author), Univ Porto, Inst Saude Publ, Rua Taipas 135, P-4050600 Oporto, Portugal.
EM liane@med.up.pt
RI Barros, Henrique/Q-8609-2019; Afonso, Carlos/M-7833-2013; ,
   Teresa/HSF-0698-2023; Azevedo, Ana/AAA-2287-2020; Correia-Costa,
   Liane/JPA-4135-2023; Morato, Manuela/D-7563-2013; Afonso,
   Joana/A-4395-2016; Albino-Teixeira, Antonio/HPI-0713-2023
OI Correia-Costa, Liane/0000-0002-8216-090X; Sousa,
   Teresa/0000-0001-7230-5020; Cosme, Dina/0000-0002-8398-0184; Barros,
   Henrique/0000-0003-4699-6571; Morato, Manuela/0000-0002-9509-0613;
   Azevedo, Ana/0000-0002-7368-9609; Caldas Afonso,
   Alberto/0000-0002-2574-4132; Albino-Teixeira,
   Antonio/0000-0003-0097-2953; Areias, Jose Carlos/0000-0002-9833-2518
FU FEDER funds from Programa Operacional Factores de Competitividade -
   COMPETE; national funds from the Portuguese Foundation for Science and
   Technology, Lisbon, Portugal [PTDC/DTP-PIC/0239/2012]; Portuguese
   Foundation for Science and Technology [SFRH/SINTD/95898/2013]; ERA-EDTA
   Research Programme; KfH Foundation for Preventive Medicine; 
   [FCOMP-01-0124-FEDER-028751]; Fundação para a Ciência e a Tecnologia
   [SFRH/SINTD/95898/2013, PTDC/DTP-PIC/0239/2012] Funding Source: FCT
FX This project was supported by FEDER funds from Programa Operacional
   Factores de Competitividade - COMPETE. FCOMP-01-0124-FEDER-028751 and by
   national funds from the Portuguese Foundation for Science and
   Technology, Lisbon, Portugal (PTDC/DTP-PIC/0239/2012), that granted the
   funds for study design and data collection and analysis. Liane
   Correia-Costa was supported by Portuguese Foundation for Science and
   Technology (grant SFRH/SINTD/95898/2013) and Franz Schaefer was
   supported by the ERA-EDTA Research Programme and the KfH Foundation for
   Preventive Medicine.
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   Urbina E, 2008, HYPERTENSION, V52, P433, DOI 10.1161/HYPERTENSIONAHA.108.190329
   van der Veen BS, 2009, ANTIOXID REDOX SIGN, V11, P2899, DOI [10.1089/ars.2009.2538, 10.1089/ARS.2009.2538]
   Van der Zwan LP, 2010, HYPERTENSION, V55, P1366, DOI 10.1161/HYPERTENSIONAHA.109.147231
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NR 42
TC 19
Z9 21
U1 0
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0014-2972
EI 1365-2362
J9 EUR J CLIN INVEST
JI Eur. J. Clin. Invest.
PD JAN
PY 2016
VL 46
IS 1
BP 50
EP 59
DI 10.1111/eci.12564
PG 10
WC Medicine, General & Internal; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Research & Experimental Medicine
GA DA6QP
UT WOS:000367930500006
PM 26541603
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Hung, WC
   Wu, JS
   Yang, YC
   Sun, ZJ
   Lu, FH
   Chang, CJ
AF Hung, Wei-Chieh
   Wu, Jin-Shang
   Yang, Yi-Ching
   Sun, Zih-Jie
   Lu, Feng-Hwa
   Chang, Chih-Jen
TI Nonalcoholic fatty liver disease vs. obesity on the risk of erosive
   oesophagitis
SO EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
LA English
DT Article
DE Body mass index; erosive oesophagitis; nonalcoholic fatty liver disease;
   obesity; waist circumference
ID GASTROESOPHAGEAL-REFLUX DISEASE; ENDOSCOPIC ASSESSMENT; METABOLIC
   SYNDROME; OXIDATIVE STRESS; ACID; STEATOHEPATITIS; ASSOCIATION;
   PREVALENCE; GUIDELINES; FIBROSIS
AB BackgroundErosive oesophagitis (EE) may be complicated by oesophageal ulcers, peptic stricture, Barrett's oesophagus and oesophageal adenocarcinoma. There have been few studies examining the influence of nonalcoholic fatty liver disease (NAFLD) on EE, and even fewer exploring the simultaneous effects of NAFLD, general and central obesity on EE. We thus aim to clarify the relationship between NAFLD and EE when general and/or central obesity are considered simultaneously.
   Materials and methodsIn this cross-sectional study, we enrolled 12090 subjects who underwent a health check-up at the Health Examination Center of a university hospital between January 2000 and August 2009 for analysis. NAFLD was diagnosed using liver ultrasound and EE was defined according to the Los Angeles classification by oesophagogastroduodenoscopy.
   ResultsSubjects with EE (1922; 159%) had a higher proportion of NAFLD, general and central obesity. With adjustment for age, gender, hypertension, diabetes mellitus, hiatal hernia, hypertriglyceridemia, high-density lipoprotein cholesterol, alcohol consumption, tea drinking, smoking and habitual exercise, the results of the multivariate analyses showed that general obesity, central obesity and NAFLD were all significantly associated with EE in their separate models. When considering general obesity, central obesity and NAFLD simultaneously, NAFLD, but neither general nor central obesity, remained positively correlated to EE. In addition, male gender, hiatal hernia and hypertriglyceridemia were all significantly associated with EE.
   ConclusionIn addition to general and central obesity, NAFLD is independently associated with increased risk of EE, and the detrimental effect of NAFLD on EE might be greater than those of general and central obesity.
C1 [Hung, Wei-Chieh] I Shou Univ, E Da Hosp, Dept Family Med, Kaohsiung, Taiwan.
   [Hung, Wei-Chieh; Wu, Jin-Shang; Yang, Yi-Ching; Lu, Feng-Hwa; Chang, Chih-Jen] Natl Cheng Kung Univ Hosp, Dept Family Med, Tainan 70403, Taiwan.
   [Wu, Jin-Shang; Yang, Yi-Ching; Lu, Feng-Hwa; Chang, Chih-Jen] Natl Cheng Kung Univ, Coll Med, Dept Family Med, Tainan 70101, Taiwan.
   [Sun, Zih-Jie] Natl Cheng Kung Univ, Coll Med & Hosp, Dept Family Med, Dou Liou, Taiwan.
   [Sun, Zih-Jie; Lu, Feng-Hwa] Natl Cheng Kung Univ, Coll Med, Inst Gerontol, Tainan 70101, Taiwan.
C3 I Shou University; E-Da Hospital; National Cheng Kung University;
   National Cheng Kung University Hospital; National Cheng Kung University;
   National Cheng Kung University; National Cheng Kung University
RP Chang, CJ (corresponding author), Natl Cheng Kung Univ Hosp, Dept Family Med, 138 Sheng Li Rd, Tainan 70403, Taiwan.
EM changcj.ncku@gmail.com
RI Chen, Yun-Yu/IXO-3895-2023; Yang, Yi-Ching/C-7033-2014
OI Yang, Yi-Ching/0000-0003-1391-8040; Hung, Wei Chieh/0000-0002-5163-8712
FU Department of Family Medicine, National Cheng-Kung University Hospital,
   Taiwan [NCKUHFM-101-003]
FX This work was supported by the Department of Family Medicine, National
   Cheng-Kung University Hospital, Taiwan [Grant number NCKUHFM-101-003].
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NR 45
TC 15
Z9 15
U1 0
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0014-2972
EI 1365-2362
J9 EUR J CLIN INVEST
JI Eur. J. Clin. Invest.
PD DEC
PY 2014
VL 44
IS 12
BP 1143
EP 1149
DI 10.1111/eci.12348
PG 7
WC Medicine, General & Internal; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Research & Experimental Medicine
GA AU7CW
UT WOS:000345759100001
PM 25293867
DA 2025-06-11
ER

PT J
AU Sridhar, SB
   Xu, F
   Darbinian, J
   Quesenberry, CP
   Ferrara, A
   Hedderson, MM
AF Sridhar, Sneha B.
   Xu, Fei
   Darbinian, Jeanne
   Quesenberry, Charles P.
   Ferrara, Assiamira
   Hedderson, Monique M.
TI Pregravid Liver Enzyme Levels and Risk of Gestational Diabetes Mellitus
   During a Subsequent Pregnancy
SO DIABETES CARE
LA English
DT Article
ID GAMMA-GLUTAMYL-TRANSFERASE; INSULIN-RESISTANCE; ALANINE
   AMINOTRANSFERASE; METABOLIC SYNDROME; OXIDATIVE STRESS; TRANSPEPTIDASE;
   ASSOCIATION; PREDICTOR; DISEASE; PLASMA
AB OBJECTIVE
   Liver enzymes are independent predictors of type 2 diabetes. Although liver fat content correlates with features of insulin resistance, a risk factor for developing gestational diabetes mellitus (GDM), the relationship between liver enzymes and GDM is unclear. The objective of this study was to assess whether pregravid liver enzyme levels are associated with subsequent risk of GDM.
   RESEARCH DESIGN AND METHODS
   A nested case-control study was conducted among women who participated in the Kaiser Permanente Northern California multiphasic health checkup (1984-1996) and had a subsequent pregnancy (1984-2009). Case patients were 256 women who developed GDM. Two control subjects were selected for each case patient and matched for year of blood draw, age at examination, age at pregnancy, and number of intervening pregnancies.
   RESULTS
   Being in the highest quartile versus the lowest quartile of gamma-glutamyl transferase (GGT) levels was associated with a twofold increased risk of subsequent GDM (odds ratio 1.97 [95% CI 1.14-3.42]), after adjusting for race/ethnicity, prepregnancy BMI, family history of diabetes, and alcohol use. This result was attenuated after adjusting for homeostasis model assessment of insulin resistance (HOMA-IR), fasting status, and rate of gestational weight gain. There was significant interaction between GGT and HOMA-IR; the association with GGT was found among women in the highest tertile of HOMA-IR. Aspartate aminotransferase and alanine aminotransferase were not associated with increased GDM risk.
   CONCLUSIONS
   Pregravid GGT level, but not alanine aminotransferase or aspartate aminotransferase level, predicted the subsequent risk of GDM. Markers of liver fat accumulation, such as GGT level, are present years before pregnancy and may help to identify women at increased risk for subsequent GDM.
C1 [Sridhar, Sneha B.; Xu, Fei; Darbinian, Jeanne; Quesenberry, Charles P.; Ferrara, Assiamira; Hedderson, Monique M.] Kaiser Permanente No Calif, Div Res, Oakland, CA 94611 USA.
C3 Kaiser Permanente
RP Sridhar, SB (corresponding author), Kaiser Permanente No Calif, Div Res, Oakland, CA 94611 USA.
EM sneha.x.sridhar@kp.org
OI Ferrara, Assiamira/0000-0002-7505-4826
FU National Institutes of Health [P30-DK-092924]; Eunice Kennedy Shriver
   National Institute of Child Health and Human Development [R01-HD-065904]
FX A.F. was supported by National Institutes of Health grant P30-DK-092924.
   This research was also supported by Eunice Kennedy Shriver National
   Institute of Child Health and Human Development grant R01-HD-065904 to
   M.M.H.
CR Amer Diabet Assoc, 2000, DIABETES CARE, V23, pS77
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NR 34
TC 38
Z9 45
U1 0
U2 13
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0149-5992
EI 1935-5548
J9 DIABETES CARE
JI Diabetes Care
PD JUL
PY 2014
VL 37
IS 7
BP 1878
EP 1884
DI 10.2337/dc13-2229
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA AJ9HX
UT WOS:000338020400021
PM 24795397
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Wattez, JS
   Delahaye, F
   Barella, LF
   Dickes-Coopman, A
   Montel, V
   Breton, C
   Mathias, P
   Foligné, B
   Lesage, J
   Vieau, D
AF Wattez, J. -S.
   Delahaye, F.
   Barella, L. F.
   Dickes-Coopman, A.
   Montel, V.
   Breton, C.
   Mathias, P.
   Foligne, B.
   Lesage, J.
   Vieau, D.
TI Short- and long-term effects of maternal perinatal undernutrition are
   lowered by cross-fostering during lactation in the male rat
SO JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE
LA English
DT Article
DE cross-fostering; DOHaD; lactation; leptin; undernutrition
ID CATCH-UP GROWTH; PITUITARY-ADRENAL AXIS; DIET-INDUCED OBESITY; HIGH-FAT
   DIET; DEVELOPMENTAL ORIGINS; GLUCOSE-INTOLERANCE; METABOLIC SYNDROME;
   HYPOTHALAMIC CART; LEPTIN RESISTANCE; FOOD RESTRICTION
AB Undernutrition exposure during the perinatal period reduces the growth kinetic of the offspring and sensitizes it to the development of chronic adult metabolic diseases both in animals and in humans. Previous studies have demonstrated that a 50% maternal food restriction performed during the last week of gestation and during lactation has both short-and long-term consequences in the male rat offspring. Pups from undernourished mothers present a decreased intrauterine (IUGR) and extrauterine growth restriction. This is associated with a drastic reduction in their leptin plasma levels during lactation, and exhibit programming of their stress neuroendocrine systems (corticotroph axis and sympathoadrenal system) in adulthood. In this study, we report that perinatally undernourished 6-month-old adult animals demonstrated increased leptinemia (at PND200), blood pressure (at PND180), food intake (from PND28 to PND168), locomotor activity (PND187) and altered regulation of glycemia (PND193). Cross-fostering experiments indicate that these alterations were prevented in IUGR offspring nursed by control mothers during lactation. Interestingly, the nutritional status of mothers during lactation (ad libitum feeding v. undernutrition) dictates the leptin plasma levels in pups, consistent with decreased leptin concentration in the milk of mothers subjected to perinatal undernutrition. As it has been reported that postnatal leptin levels in rodent neonates may have long-term metabolic consequences, restoration of plasma leptin levels in pups during lactation may contribute to the beneficial effects of cross-fostering IUGR offspring to control mothers. Collectively, our data suggest that modification of milk components may offer new therapeutic perspectives to prevent the programming of adult diseases in offspring from perinatally undernourished mothers.
C1 [Wattez, J. -S.; Delahaye, F.; Dickes-Coopman, A.; Montel, V.; Breton, C.; Lesage, J.; Vieau, D.] Univ Lille 1, Univ Lille Nord France, Equipe Denutr Maternelles Perinatales, Environm Perinatal & Croissance EA4489,SN4, F-59655 Villeneuve Dascq, France.
   [Delahaye, F.] Albert Einstein Coll Med, Dept Genet, Bronx, NY 10467 USA.
   [Barella, L. F.; Mathias, P.] Univ Estadual Maringa, Dept Cell Biol & Genet, Lab Secret Cell Biol, Maringa, Parana, Brazil.
   [Foligne, B.] Inst Pasteur, Ctr Infect & Immun Lille 1, F-59019 Lille, France.
   [Foligne, B.] Inst Pasteur, Ctr Immunol & Biol Parasitaire, CNRS, UMR 8204, F-59019 Lille, France.
   [Foligne, B.] INSERM, U1019, F-59045 Lille, France.
C3 Universite de Lille; Montefiore Medical Center; Albert Einstein College
   of Medicine; Yeshiva University; Universidade Estadual de Maringa;
   Pasteur Network; Universite de Lille; Institut Pasteur Lille; Pasteur
   Network; Universite de Lille; Institut Pasteur Lille; Centre National de
   la Recherche Scientifique (CNRS); CNRS - National Institute for Biology
   (INSB); Universite de Lille; Institut National de la Sante et de la
   Recherche Medicale (Inserm)
RP Vieau, D (corresponding author), Univ Lille 1, Univ Lille Nord France, Equipe Denutr Maternelles Perinatales, Environm Perinatal & Croissance EA4489,SN4, F-59655 Villeneuve Dascq, France.
EM didier.vieau@univ-lille1.fr
RI DE FREITAS MATHIAS, PAULO/AAQ-9682-2021; lesage, jean/R-5019-2018;
   Foligne, Benoit/B-2754-2014; Barella, Luiz Felipe/C-1181-2014
OI lesage, jean/0000-0002-6329-1613; vieau, didier/0000-0002-3254-3662;
   Montel, Valerie/0000-0002-7286-4209; Wattez,
   Jean-Sebastien/0000-0003-0213-4662; Delahaye,
   Fabien/0000-0002-9921-8653; Foligne, Benoit/0000-0001-9263-9706; de
   Freitas Mathias, Paulo Cezar/0000-0001-6994-4585; Wattez,
   Jean-Sebastien/0000-0001-9482-0621; Barella, Luiz
   Felipe/0000-0003-2211-3842
FU French Ministry of Education; Conseil Regional du Nord-Pas-de Calais
FX This study was supported by grants from the French Ministry of Education
   and grants of the Conseil Regional du Nord-Pas-de Calais.
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NR 62
TC 24
Z9 25
U1 0
U2 8
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 2040-1744
EI 2040-1752
J9 J DEV ORIG HLTH DIS
JI J. Dev. Orig. Health Dis.
PD APR
PY 2014
VL 5
IS 2
BP 109
EP 120
DI 10.1017/S2040174413000548
PG 12
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA AJ5VK
UT WOS:000337757700006
PM 24847697
DA 2025-06-11
ER

PT J
AU Aliev, G
   Shahida, K
   Gan, SH
   Firoz, CK
   Khan, A
   Abuzenadah, AM
   Kamal, W
   Kamal, MA
   Tan, Y
   Qu, XQ
   Reale, M
AF Aliev, Gjumrakch
   Shahida, Khan
   Gan, Siew Hua
   Firoz, C. K.
   Khan, Aziz
   Abuzenadah, Adel M.
   Kamal, Warda
   Kamal, Mohammad A
   Tan, Yi
   Qu, Xianqin
   Reale, Marcella
TI Alzheimer Disease and Type 2 Diabetes Mellitus: The Link to Tyrosine
   Hydroxylase and Probable Nutritional Strategies
SO CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
LA English
DT Article
DE Alzheimer disease; type 2 diabetes mellitus; tyrosine hydroxylase;
   nutritional strategies
ID INSULIN-RESISTANCE; COGNITIVE IMPAIRMENT; GENE-EXPRESSION;
   NERVOUS-SYSTEM; MEDITERRANEAN DIET; METABOLIC SYNDROME; OXIDATIVE
   STRESS; FISH CONSUMPTION; ADIPOSE-TISSUE; OLDER-ADULTS
AB Alzheimer disease (AD) and type 2 diabetes mellitus (T2DM) are chronic health disorders that affect millions of people around the world. According to recent studies, there are molecular similarities in the inflammatory pathways involved in both AD and T2DM, which opens a new avenue for researchers with different perspectives to target the cause of these diseases rather than their obvious symptoms. Several links between inflammation, cardiovascular disease, T2DM and central nervous system disorders such as AD and Parkinson's disease have been elucidated. Mutations in the hippocampal-beta-amyloid precursor protein gene in genetically high-risk individuals have been shown to cause the early onset of AD symptoms. The overexpression of beta-amyloid protein in the hippocampal region and the synaptotoxicity that occurs as a result have been considered a typical feature of AD and leads to neuronal loss and cognitive decline. However, the identity of the cellular components that cause the late onset of the disease seen in the majority of the cases is still unknown. Synaptic insults associated with neuronal dysfunction may involve several cascades and molecules, one of which has been hypothesized to be tyrosine hydroxylase (TH). The axons of the noradrenergic cells that project to the hippocampus appear to be affected by the beta-amyloid protein, which subsequently contributes to TH loss in Alzheimer brain cells. In this review, we attempt to shed light on the important mechanisms involved in AD as well as T2DM such as inflammatory factors, abnormalities in the insulin signaling system and the possible role of the endocrine enzyme TH.
C1 [Aliev, Gjumrakch] GALLY Int Biomed Res Consulting LLC, San Antonio, TX 78229 USA.
   [Aliev, Gjumrakch] Univ Atlanta, Dept Hlth Sci & Healthcare Adm, Atlanta, GA 30097 USA.
   [Shahida, Khan; Firoz, C. K.; Khan, Aziz; Abuzenadah, Adel M.; Kamal, Mohammad A] King Abdulaziz Univ, King Fahd Med Res Ctr, Jeddah 21589, Saudi Arabia.
   [Gan, Siew Hua] Univ Sains Malaysia, Sch Med Sci, Ctr Human Genome, Kubang Kerian, Kelantan, Malaysia.
   [Tan, Yi; Qu, Xianqin] Univ Technol Sydney, Sch Med & Mol Biosci, Sydney, NSW 2007, Australia.
   [Reale, Marcella] Univ G dAnnunzio, Det Expt & Clin Sci, I-66100 Chieti, Italy.
C3 Gally International Biomedical Research & Consulting LLC; King Abdulaziz
   University; Universiti Sains Malaysia; University of Technology Sydney;
   G d'Annunzio University of Chieti-Pescara
RP Kamal, MA (corresponding author), King Abdulaziz Univ, King Fahd Med Res Ctr, Fundamental & Appl Biol Grp, Jeddah 21589, Saudi Arabia.
EM meu.fabg@hotmail.com; mreale@unich.it
RI Khan, Shahida/H-9636-2012; Aliev, Gjumrakch/AAE-7734-2020; Reale,
   Marcella/G-4299-2013; CHELAPRAM KANDY, FIROZ/H-9487-2012; gan, siew
   hua/A-6266-2011; Kamal, Mohammad Amjad/J-2918-2014
OI CHELAPRAM KANDY, FIROZ/0000-0002-8832-9411; gan, siew
   hua/0000-0001-6470-3651; Kamal, Mohammad Amjad/0000-0003-0088-0565;
   Aliev, Gjumrakch/0000-0001-7373-3182; Reale,
   Marcella/0000-0002-4164-8781
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NR 113
TC 17
Z9 19
U1 2
U2 15
PU BENTHAM SCIENCE PUBL
PI BUSUM
PA PO BOX 294, BUSUM, 1400 AG, NETHERLANDS
SN 1871-5273
EI 1996-3181
J9 CNS NEUROL DISORD-DR
JI CNS Neurol. Disord.-Drug Targets
PY 2014
VL 13
IS 3
BP 467
EP 477
DI 10.2174/18715273113126660153
PG 11
WC Neurosciences; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pharmacology & Pharmacy
GA AN8EM
UT WOS:000340836000013
PM 24059309
DA 2025-06-11
ER

PT J
AU Du, GL
   Song, ZY
   Zhang, Q
AF Du, Guangli
   Song, Ziyu
   Zhang, Qin
TI Gamma-glutamyltransferase is associated with cardiovascular and
   all-cause mortality: A meta-analysis of prospective cohort studies
SO PREVENTIVE MEDICINE
LA English
DT Article
DE Gamma-glutamyltransferase; Cardiovascular mortality; All-cause
   mortality; Meta-analysis
ID FATTY LIVER-DISEASE; RISK-FACTORS; METABOLIC SYNDROME; HEPATIC
   STEATOSIS; OXIDATIVE STRESS; HEART-DISEASE; UNITED-STATES; POPULATION;
   PREVALENCE; EVENTS
AB Objective: The purpose of the present study was to investigate whether gamma-glutamyltransferase (GGT) is an independent predictor for future cardiovascular (CV) and all-cause mortality with prospective observational studies by meta-analysis.
   Methods: Electronic literature databases (Cochrane Library, Medline, and Embase) were searched for relevant prospective observational studies on the association between baseline GGT and CV and all-cause mortality published prior to June 2012. Pooled adjust relative risk (RR) and corresponding 95% confidence intervals(CI) were calculated separately for categorical risk estimates(highest vs. lowest GGT quartile) and continuous risk estimates (per unit-log GGT increment).
   Results: Seven studies with 273,141 participants were identified and analyzed. The pooled RR of CV mortality for highest vs. lowest GGT quartile was 1.52 (95% Cl 136-1.70). The pooled RR of CV mortality for per unit-log (GGT) increment was 1.76(95% CI 1.60-1.94). The pooled RR for all-cause mortality for highest vs. low GGT quartile was 1.56(95% CI 134-1.83). Subgroup analyses based on region, gender, follow-up duration, and sample size showed that the positive association between GGT and risk of CV mortality was consistently observed in each subgroup except for the Asia subgroup (RR = 1.59,95% Cl 0.76-330).
   Conclusions: GGT is an independent predictor for future CV mortality and all-cause mortality, and might be independent of alcohol intake. (C) 2013 Elsevier Inc. All rights reserved.
C1 [Du, Guangli] Shanghai Univ Tradit Chinese Med, Sch Pharm, Shanghai 201203, Peoples R China.
   [Song, Ziyu; Zhang, Qin] Shanghai Changning Cent Hosp, Dept Infect, Shanghai 200336, Peoples R China.
C3 Shanghai University of Traditional Chinese Medicine
RP Zhang, Q (corresponding author), Shanghai Changning Cent Hosp, 1111 Xianxia Rd, Shanghai 200336, Peoples R China.
EM zhangqinshh@126.com
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NR 45
TC 58
Z9 59
U1 0
U2 7
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0091-7435
EI 1096-0260
J9 PREV MED
JI Prev. Med.
PD JUL
PY 2013
VL 57
IS 1
BP 31
EP 37
DI 10.1016/j.ypmed.2013.03.011
PG 7
WC Public, Environmental & Occupational Health; Medicine, General &
   Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health; General & Internal Medicine
GA 164SI
UT WOS:000320429400007
PM 23571185
DA 2025-06-11
ER

PT J
AU Westerlund, H
   Gustafsson, PE
   Theorell, T
   Janlert, U
   Hammarström, A
AF Westerlund, Hugo
   Gustafsson, Per E.
   Theorell, Tores
   Janlert, Urban
   Hammarstrom, Anne
TI Parental academic involvement in adolescence, academic achievement over
   the life course and allostatic load in middle age: a prospective
   population-based cohort study
SO JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH
LA English
DT Article
ID SOCIOECONOMIC-STATUS; METABOLIC SYNDROME; ADULTHOOD; HEALTH; WOMEN;
   RISK; MEN
AB Background Parental involvement in their children's studies, particularly in terms of academic socialisation, has been shown to predict academic achievement, and is thus a candidate modifiable factor influencing life course socioeconomic circumstances. Socioeconomic disadvantage is thought to impact on health over the life course partly by allostatic load, that is, cumulative biological risk. We sought to elucidate the role of parental involvement at age 16 on the life course development of allostatic load.
   Methods In a population-based cohort (365 women and 352 men, 67% of the eligible participants), we examined the association between parental involvement in their offspring's studies, measured by teacher and pupil ratings at age 16 and an allostatic load index summarising 12 physiological risk markers at age 43. Mediation through life course academic and occupational achievement was assessed by entering school grades, adult educational achievement and socioeconomic position at age 43 in a linear regression analysis in a stepwise manner and testing for mediation.
   Results Parental interest in their offspring's studies during the last year of compulsory school-rather than the parent's social class or availability of practical academic support-was found to predict adult allostatic load (beta=-0.12, 95% CI -0.20 to -0.05). Further adjustments indicated that academic achievement over the life course mediated a large part of the effect of parental interest on allostatic load.
   Conclusions Parental interest in their offspring's studies may have protective effects by decreasing the likelihood of a chain of risk involving low academic achievement, low socioeconomic position and high accumulated physiological stress.
C1 [Westerlund, Hugo; Theorell, Tores] Stockholm Univ, Stress Res Inst, Div Epidemiol, SE-10691 Stockholm, Sweden.
   [Gustafsson, Per E.; Janlert, Urban; Hammarstrom, Anne] Umea Univ, Dept Publ Hlth & Clin Med, Umea, Sweden.
C3 Stockholm University; Umea University
RP Westerlund, H (corresponding author), Stockholm Univ, Stress Res Inst, SE-10691 Stockholm, Sweden.
EM hugo.westerlund@stress.su.se
RI Gustafsson, Per/AAY-5068-2021; Hammarström, Anne/HNI-3080-2023;
   Westerlund, Hugo/IZP-7925-2023
OI Theorell, Tores/0000-0003-1956-7931; Gustafsson, Per
   E/0000-0002-3972-5362; Hammarstrom, Anne/0000-0002-4095-7961
FU Swedish Research Council (VR) [521-2005-4084]; Swedish Council for
   Working Life and Social Research (FAS) [2006-0950, 2009-1758]; Umea
   University [223-514-09]
FX This work was supported by the Swedish Research Council (VR,
   #521-2005-4084) and by the Swedish Council for Working Life and Social
   Research (FAS, #2006-0950 and #2009-1758). PEG was supported by Umea
   University (Young Researcher Award; #223-514-09). The funding bodies had
   no role in study design; in collection, analysis or interpretation of
   the data or in the writing or submission of the manuscript.
CR [Anonymous], CSDH FIN REP CLOS GA
   [Anonymous], ADULT POPULATIONS ST
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NR 22
TC 24
Z9 27
U1 0
U2 47
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 0143-005X
EI 1470-2738
J9 J EPIDEMIOL COMMUN H
JI J. Epidemiol. Community Health
PD JUN
PY 2013
VL 67
IS 6
BP 508
EP 513
DI 10.1136/jech-2012-202052
PG 6
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA 138ED
UT WOS:000318490600010
PM 23493586
DA 2025-06-11
ER

PT J
AU Panahi, Y
   Ghamarchehreh, ME
   Beiraghdar, F
   Zare, M
   Jalalian, HR
   Sahebkar, A
AF Panahi, Yunes
   Ghamarchehreh, Mohammad Ebrahim
   Beiraghdar, Fatemeh
   Zare, Marjan
   Jalalian, Hamid Reza
   Sahebkar, Amirhossein
TI Investigation of the Effects of Chlorella Vulgaris
   Supplementation in Patients with Non-Alcoholic Fatty Liver Disease: A
   Randomized Clinical Trial
SO HEPATO-GASTROENTEROLOGY
LA English
DT Article
DE Chlorella vulgaris; Non-alcoholic fatty liver disease; Insulin
   resistance; Hepatic injury; Transaminase; Lipid profile
ID SERUM URIC-ACID; PLACEBO-CONTROLLED TRIAL; METABOLIC SYNDROME;
   INSULIN-RESISTANCE; TRIGLYCERIDE LEVELS; DIABETES-MELLITUS; OXIDATIVE
   STRESS; ASSOCIATION; RATS; STEATOHEPATITIS
AB Background/Aims: To investigate the advantage of Chlorella vulgaris supplementation as an adjunctive therapy in patients with non-alcoholic fatty liver disease (NAFLD). Methodology: In a randomized, open-label clinical trial, 76 individuals with NAFLD were randomly assigned to: 1) Chlorella group (n=33), receiving C. vulgaris extract (1200mg/day) + metformin (750mg/day) + vitamin E (200mg/day) for 3 months, or 2) Metformin group (n=43), receiving metformin (1250mg/day) + vitamin E (200mg/day) for 3 months. Weight, body mass index (BMI), homeostasis model assessment of insulin resistance (HOMA-IR) index as well as serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), insulin, total and direct bilirubin, fasting blood sugar (FBS), glycated hemoglobin (HbA(1c)), uric acid, albumin and lipid profile were evaluated at baseline and at the end of trial. Results: Weight and BMI were decreased in both groups. Serum ALT, AST, triglycerides, uric acid, HbA(1c) and HOMA-IR index were reduced only in the Chlorella group whereas significant changes in total cholesterol, LDL, HDL and FBS were only observed in the metformin group. There were also borderline significant reductions in insulin and FBS in the Chlorella group. Conclusions: The findings of the present trial indicated that addition of C. vulgaris extract to the therapeutic regimen of NAFLD including metformin and vitamin E, is associated with favorable effects on serum levels of transaminases, triglycerides as well as insulin sensitivity Therefore, C. vulgaris extract might be a promising hepatoprotective supplement for patients with NAFLD.
C1 [Panahi, Yunes] Baqiyatallah Univ Med Sci, Res Ctr Chem Injuries, Fac Med, Tehran, Iran.
   [Ghamarchehreh, Mohammad Ebrahim] Baqiyatallah Univ Med Sci, Res Ctr Gastroenterol & Liver Dis, Fac Med, Tehran, Iran.
   [Beiraghdar, Fatemeh] Baqiyatallah Univ Med Sci, Nephrol & Urol Res Ctr, Fac Med, Tehran, Iran.
   [Jalalian, Hamid Reza] Baqiyatallah Univ Med Sci, Dept Internal Med, Fac Med, Tehran, Iran.
   [Zare, Marjan] Islamic Azad Univ, Pharmaceut Sci Branch, Tehran, Iran.
   [Sahebkar, Amirhossein] MUMS, Avicenna Res Inst, Cardiovasc Res Ctr, Mashhad, Iran.
   [Sahebkar, Amirhossein] MUMS, Biotechnol Res Ctr, Mashhad, Iran.
   [Sahebkar, Amirhossein] MUMS, Sch Pharm, Mashhad, Iran.
C3 Baqiyatallah University of Medical Sciences (BMSU); Baqiyatallah
   University of Medical Sciences (BMSU); Baqiyatallah University of
   Medical Sciences (BMSU); Baqiyatallah University of Medical Sciences
   (BMSU); Islamic Azad University; Mashhad University of Medical Sciences;
   Mashhad University of Medical Sciences; Mashhad University of Medical
   Sciences
RP Panahi, Y (corresponding author), Baqiyatallah Univ Med Sci, Res Ctr Chem Injuries, Fac Med, Molla Sadra St,POB 19945-581, Tehran, Iran.
EM yunespanahi@yahoo.com
RI Mirahmadizadeh, Alireza/I-9178-2016; Sahebkar, Amirhossein/B-5124-2018
OI ghamar chehreh, Mohammad Ebrahim/0000-0003-1331-0262; Jalalian,
   Hamidreza/0000-0002-7271-485X
FU Baqiyatallah University of Medical Sciences (Tehran, Iran)
FX This work was financially supported by a grant from the Baqiyatallah
   University of Medical Sciences (Tehran, Iran).
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NR 43
TC 41
Z9 44
U1 0
U2 28
PU H G E UPDATE MEDICAL PUBLISHING S A
PI ATHENS
PA PO BOX 17257, ATHENS GR-10024, GREECE
SN 0172-6390
J9 HEPATO-GASTROENTEROL
JI Hepato-Gastroenterol.
PD OCT
PY 2012
VL 59
IS 119
BP 2099
EP 2103
DI 10.5754/hge10860
PG 5
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA 059FG
UT WOS:000312689200016
PM 23234816
DA 2025-06-11
ER

PT J
AU Gómez-Hernández, A
   Otero, YF
   de las Heras, N
   Escribano, O
   Cachofeiro, V
   Lahera, V
   Benito, M
AF Gomez-Hernandez, Almudena
   Otero, Yolanda F.
   de las Heras, Natalia
   Escribano, Oscar
   Cachofeiro, Victoria
   Lahera, Vicente
   Benito, Manuel
TI Brown Fat Lipoatrophy and Increased Visceral Adiposity through a
   Concerted Adipocytokines Overexpression Induces Vascular Insulin
   Resistance and Dysfunction
SO ENDOCRINOLOGY
LA English
DT Article
ID NITRIC-OXIDE SYNTHASE; TUMOR-NECROSIS-FACTOR; FACTOR-KAPPA-B;
   DIET-INDUCED OBESITY; FACTOR-ALPHA; ENDOTHELIAL DYSFUNCTION;
   SKELETAL-MUSCLE; TNF-ALPHA; METABOLIC SYNDROME; MICE
AB In this study, we analyzed the role played by concerted expression of adipocytokines associated with brown fat lipoatrophy and increased visceral adiposity on triggering vascular insulin resistance and dysfunction in brown adipose tissue (BAT) insulin receptor knockout (BATIRKO) mice. In addition, we assessed whether vascular insulin resistance may aggravate vascular damage. The 52-wk-old, but not 33-wk-old, BATIRKO mice had a significant decrease of BAT mass associated with a significant increase of visceral white adipose tissue (WAT) mass, without changes in body weight. Brown fat lipoatrophy and increased visceral adiposity enhanced the concerted expression of adipocytokines (TNF-alpha, leptin, and plasminogen activator inhibitor 1) and nuclear factor-kappa B binding activity in BAT and visceral WAT, mainly in the gonadal depot, and aorta. Although those mice showed insulin sensitivity in the liver and skeletal muscle, insulin signaling in WAT (gonadal depot) and aorta was markedly impaired. Treatment with anti-TNF-alpha antibody impaired the inflammatory activity in visceral adipose tissue, attenuated insulin resistance in WAT and aorta and induced glucose tolerance. Finally, 52-wk-old BATIRKO mice showed vascular dysfunction, macrophage infiltration, oxidative stress, and a significant increase of gene markers of endothelial activation and inflammation, the latter effect being totally reverted by anti-TNF-alpha antibody treatment. Our results suggest that brown fat lipoatrophy and increased visceral adiposity through the concerted overexpression of cytoadipokines induces nuclear factor-kappa B-mediated inflammatory signaling, vascular insulin resistance, and vascular dysfunction. Inhibition of inflammatory activity by anti-TNF-alpha antibody treatment attenuates vascular insulin resistance and impairs gene expression of vascular dysfunction markers. (Endocrinology 153: 1242-1255, 2012)
C1 [Gomez-Hernandez, Almudena; Otero, Yolanda F.; Escribano, Oscar; Benito, Manuel] Univ Complutense Madrid, Sch Pharm, Biochem & Mol Biol Dept, Madrid 28040, Spain.
   [de las Heras, Natalia; Cachofeiro, Victoria; Lahera, Vicente] Univ Complutense Madrid, Sch Med, Dept Physiol, Madrid 28040, Spain.
   [Gomez-Hernandez, Almudena; Otero, Yolanda F.; Escribano, Oscar; Benito, Manuel] Biomed Res Network CIBER Diabet & Related Metab D, Madrid 28040, Spain.
   [de las Heras, Natalia; Cachofeiro, Victoria; Lahera, Vicente] Spanish Network Cardiovasc Res, Madrid 28040, Spain.
C3 Complutense University of Madrid; Complutense University of Madrid
RP Benito, M (corresponding author), Univ Complutense Madrid, Sch Pharm, Biochem & Mol Biol Dept, Madrid 28040, Spain.
EM benito@farm.ucm.es
RI Benito, Melissa/IAP-0513-2023; Benito, Manuel/J-5637-2014; Escribano,
   Oscar/I-6701-2016
OI Cachofeiro, Victoria/0000-0001-6959-6293; Benito,
   Manuel/0000-0002-7218-406X; Escribano, Oscar/0000-0002-8249-1645; DE LAS
   HERAS, NATALIA/0000-0002-2960-6175; Lahera, Vicente/0000-0002-9688-4503
FU Ministerio de Ciencia e Innovacion, Spain [SAF2007/60058,
   SAF2008/00031]; Instituto de Salud Carlos III
FX This work was supported by Grants SAF2007/60058 and SAF2008/00031 from
   Ministerio de Ciencia e Innovacion, Spain. Biomedical research network
   of Diabetes and Associated metabolic diseases (CIBERDEM) is an Instituto
   de Salud Carlos III Project.
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NR 56
TC 28
Z9 34
U1 0
U2 6
PU ENDOCRINE SOC
PI CHEVY CHASE
PA 8401 CONNECTICUT AVE, SUITE 900, CHEVY CHASE, MD 20815-5817 USA
SN 0013-7227
J9 ENDOCRINOLOGY
JI Endocrinology
PD MAR
PY 2012
VL 153
IS 3
BP 1242
EP 1255
DI 10.1210/en.2011-1765
PG 14
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 897JG
UT WOS:000300645600029
PM 22253415
OA Bronze
DA 2025-06-11
ER

PT J
AU Darrow, AL
   Shohet, RV
   Maresh, JG
AF Darrow, April L.
   Shohet, Ralph V.
   Maresh, J. Gregory
TI Transcriptional analysis of the endothelial response to diabetes reveals
   a role for galectin-3
SO PHYSIOLOGICAL GENOMICS
LA English
DT Article
DE gene expression; microarray; vascular biology; endothelial dysfunction;
   metabolic syndrome
ID POTENTIAL THERAPEUTIC TARGET; INSULIN-RESISTANCE; IN-VIVO;
   GENE-EXPRESSION; INFLAMMATION; IDENTIFICATION; RECEPTOR; LIVER;
   ATHEROSCLEROSIS; DYSFUNCTION
AB Darrow AL, Shohet RV, Maresh JG. Transcriptional analysis of the endothelial response to diabetes reveals a role for galectin-3. Physiol Genomics 43: 1144-1152, 2011. First published July 26, 2011; doi:10.1152/physiolgenomics.00035.2011.-To characterize the endothelial dysfunction associated with Type II diabetes, we surveyed transcriptional responses in the vascular endothelia of mice receiving a diabetogenic, high-fat diet. Tie2-GFP mice were fed a diet containing 60% fat calories (HFD); controls were littermates fed normal chow. Following 4, 6, and 8 wk, aortic and leg muscle tissues were enzymatically dispersed, and endothelial cells were obtained by fluorescence-activated cell sorting. Relative mRNA abundance in HFD vs. control endothelia was measured with long-oligo microarrays; highly dysregulated genes were confirmed by real-time PCR and protein quantification. HFD mice were hyperglycemic by 2 wk and displayed vascular insulin resistance and decreased glucose tolerance by 5 and 6 wk, respectively. Endothelial transcripts upregulated by HFD included galectin-3 (Lgals3), 5-lipoxygenase-activating protein, and chemokine ligands 8 and 9. Increased LGALS3 protein was detected in muscle endothelium by immunohistology accompanied by elevated LGALS3 in the serum of HFD mice. Our comprehensive analysis of the endothelial transcriptional response in a model of Type II diabetes reveals novel regulation of transcripts with roles in inflammation, insulin sensitivity, oxidative stress, and atherosclerosis. Increased endothelial expression and elevated humoral levels of LGALS3 supports a role for this molecule in the vascular response to diabetes, and its potential as a direct biomarker for the inflammatory state in diabetes.
C1 [Darrow, April L.; Shohet, Ralph V.; Maresh, J. Gregory] Univ Hawaii, John A Burns Sch Med, Dept Med, Honolulu, HI 96813 USA.
   [Darrow, April L.; Shohet, Ralph V.; Maresh, J. Gregory] Univ Hawaii, John A Burns Sch Med, Cardiovasc Res Ctr, Honolulu, HI 96813 USA.
   [Darrow, April L.] Univ Hawaii, John A Burns Sch Med, Dept Cell & Mol Biol, Honolulu, HI 96813 USA.
C3 University of Hawaii System; University of Hawaii System; University of
   Hawaii System
RP Shohet, RV (corresponding author), Univ Hawaii, John A Burns Sch Med, Dept Med, BSB 311,651 Ilalo St, Honolulu, HI 96813 USA.
EM shohet@hawaii.edu
FU RCMI grant [5 G12 RR003061-25]; COBRE grant [P20RR018727]; National
   Institutes of Health [5P20RR-016453, 5UH1HL-073449]; Hawaii Community
   Foundation [20061485]; American Heart Association [11PRE7720065];
   American Heart Association (AHA) [11PRE7720065] Funding Source: American
   Heart Association (AHA)
FX We thank Yvonne Baumer for generous assistance with Matrigel and
   Dil-AcLDL assays and Svenja Meiler for help with flow cytometry data
   analysis. We also thank Alexandra Gurary of the Molecular and Cellular
   Immunology Core Facility supported by RCMI (5 G12 RR003061-25) and COBRE
   (P20RR018727) grants for help with FACS and Steffen Oeser of the
   Genomics Core for performing real-time PCR and sequencing.This work was
   supported by National Institutes of Health Grants 5P20RR-016453 and
   5UH1HL-073449 (to R. V. Shohet), Hawaii Community Foundation Grant
   20061485 (to J. G. Maresh), and American Heart Association Predoctoral
   Award 11PRE7720065 (to A. L. Darrow).
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NR 46
TC 28
Z9 31
U1 0
U2 8
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 1094-8341
EI 1531-2267
J9 PHYSIOL GENOMICS
JI Physiol. Genomics
PD OCT
PY 2011
VL 43
IS 20
BP 1144
EP 1152
DI 10.1152/physiolgenomics.00035.2011
PG 9
WC Cell Biology; Genetics & Heredity; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Genetics & Heredity; Physiology
GA 841ZJ
UT WOS:000296553500003
PM 21791638
OA Green Published
DA 2025-06-11
ER

PT J
AU Moreno-Navarrete, JM
   Ortega, F
   Castro, A
   Sabater, M
   Ricart, W
   Fernández-Real, JM
AF Maria Moreno-Navarrete, Jose
   Ortega, Francisco
   Castro, Antoni
   Sabater, Monica
   Ricart, Wifredo
   Manuel Fernandez-Real, Jose
TI Circulating Omentin as a Novel Biomarker of Endothelial Dysfunction
SO OBESITY
LA English
DT Article
ID POLYCYSTIC-OVARY-SYNDROME; ADIPOSE-TISSUE; INSULIN-RESISTANCE; VASCULAR
   DYSFUNCTION; METABOLIC SYNDROME; ABDOMINAL OBESITY; OXIDATIVE STRESS;
   PLASMA-LEVELS; INFLAMMATION; RISK
AB Omentin is a novel soluble lectin expressed mainly in the stromal-vascular cells from visceral adipose tissue with vasodilator effect in isolated blood vessels. To gain insight in the relationship between obesity and cardiovascular risk factors, we aimed to explore the interaction among circulating omentin, metabolic parameters, and endothelial function. Circulating omentin (enzyme-linked immunosorbent assay) was studied in 248 white men (148 with normal glucose tolerance (NGT) and 100 with impaired glucose tolerance (IGT)). Insulin sensitivity was measured using the frequently sampled intravenous glucose tolerance test. Vascular reactivity was measured by high-resolution ultrasound of the brachial artery. Circulating omentin concentration was significantly increased in lean compared with overweight and obese subjects (53.7 +/- 16.9 vs. 45.2 +/- 16.8 and vs. 40.1 +/- 15.5 ng/ml, P < 0.0001). Circulating omentin concentration correlated with age, BMI, waist-to-hip ratio (WHR), percentage of fat mass, systolic and diastolic blood pressure, endothelium-dependent and independent vasodilation (EDV and EIV), C-reactive protein, and interleukin-6 (IL-6). In IGT subjects, circulating omentin concentration also correlated with insulin sensitivity, although this association did not remain significant after controlling for BMI. In a multiple linear regression analysis, circulating omentin concentration (P = 0.01), systolic blood pressure (P = 0.04), and BMI (P = 0.04) contributed independently to EDV after controlling for age and C-reactive protein in IGT subjects. In NGT subjects, only circulating omentin concentration (P = 0.01) was significantly associated with EDV. In conclusion, circulating omentin concentration could be a useful marker of endothelial function.
C1 [Maria Moreno-Navarrete, Jose; Ortega, Francisco; Castro, Antoni; Sabater, Monica; Ricart, Wifredo; Manuel Fernandez-Real, Jose] CIBER Fisiopatol Obesidad & Nutr CB06 03 010, Inst Invest Biomed Girona, Dept Diabet Endocrinol & Nutr, Girona, Spain.
C3 CIBER - Centro de Investigacion Biomedica en Red; CIBEROBN; Universitat
   de Girona; Girona University Hospital Dr. Josep Trueta; Institut
   d'Investigacio Biomedica de Girona (IDIBGI)
RP Fernández-Real, JM (corresponding author), CIBER Fisiopatol Obesidad & Nutr CB06 03 010, Inst Invest Biomed Girona, Dept Diabet Endocrinol & Nutr, Girona, Spain.
EM jmfernandezreal.girona.ics@gencat.cat
RI Castro, Antoni/AAI-4431-2021; Fernández-Real, Jose Manuel/AGH-3599-2022;
   Ortega, Francisco Jose/F-3883-2016; Sabater-Masdeu, Monica/G-1168-2016;
   Moreno-Navarrete, Jose Maria/H-9772-2015
OI Ricart, Wifredo/0000-0002-3452-9098; Ortega, Francisco
   Jose/0000-0003-2111-769X; Sabater-Masdeu, Monica/0000-0001-9636-0921;
   Moreno-Navarrete, Jose Maria/0000-0002-2883-511X; Fernandez-Real, Jose
   Manuel/0000-0002-7442-9323
FU Ministerio de Educacion y Ciencia [SAF2008-0273]
FX This work was partially supported by research grants from the Ministerio
   de Educacion y Ciencia (SAF2008-0273).
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NR 28
TC 120
Z9 131
U1 0
U2 8
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 1930-7381
J9 OBESITY
JI Obesity
PD AUG
PY 2011
VL 19
IS 8
BP 1552
EP 1559
DI 10.1038/oby.2010.351
PG 8
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 797XI
UT WOS:000293163000003
PM 21293447
OA Bronze
DA 2025-06-11
ER

PT J
AU Drogan, D
   Weikert, C
   Dierkes, J
   Klipstein-Grobusch, K
   Buijsse, B
   Möhlig, M
   Pfeiffer, AFH
   Pischon, T
   Spranger, J
   Boeing, H
AF Drogan, Dagmar
   Weikert, Cornelia
   Dierkes, Jutta
   Klipstein-Grobusch, Kerstin
   Buijsse, Brian
   Moehlig, Matthias
   Pfeiffer, Andreas F. H.
   Pischon, Tobias
   Spranger, Joachim
   Boeing, Heiner
TI Plasma γ-Glutamyltransferase, Cysteinyl-Glycine, and Oxidized
   Low-Density Lipoprotein A Pathway Associated With Myocardial Infarction
   Risk?
SO ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
LA English
DT Article
DE gamma-glutamyltransferase; cysteinyl-glycine; oxidized LDL; myocardial
   infarction; prospective study
ID CORONARY-HEART-DISEASE; MIDDLE-AGED MEN; CARDIOVASCULAR-DISEASE;
   METABOLIC SYNDROME; ATHEROSCLEROTIC PLAQUES; GENERAL-POPULATION; TOTAL
   HOMOCYSTEINE; APPARENTLY HEALTHY; OXIDATIVE STRESS; AUSTRIAN ADULTS
AB Objective-To investigate the interrelation between plasma gamma-glutamyltransferase (GGT) activity, cysteinyl-glycine (Cys-Gly) (ie, a thiol originating from GGT-mediated cleavage of glutathione), and oxidized low-density lipoprotein (oxLDL) with regard to myocardial infarction (MI) risk in a prospective study.
   Methods and Results-Incident cases of MI were identified among European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam participants without prior MI during 6.0 years of follow-up. Baseline levels of Cys-Gly and oxLDL and GGT activity in plasma were measured in a case-cohort study comprising 837 subjects without incident MI and 116 subjects with incident MI. The relation of GGT, Cys-Gly and oxLDL to MI risk was assessed using Cox proportional hazards regression analysis. After adjustment for established risk factors, hazard ratios associated with a 1-SD unit increase in the log-transformed biomarker were 1.63 (95% CI, 1.30 to 2.05) for GGT, 1.36 (95% CI, 1.07 to 1.72) for Cys-Gly, and 1.37 (95% CI, 1.00 to 1.86) for oxLDL. Cys-Gly and oxLDL accounted for 2.3% of the relation between GGT and MI risk.
   Conclusion-The positive association between GGT activity and MI risk appears to be independent of circulating Cys-Gly and oxLDL levels. With Cys-Gly, we found a potential new predictor of MI risk whose impact needs to be further elucidated. (Arterioscler Thromb Vasc Biol. 2010; 30: 2053-2058.)
C1 [Drogan, Dagmar; Weikert, Cornelia; Klipstein-Grobusch, Kerstin; Buijsse, Brian; Pischon, Tobias; Boeing, Heiner] German Inst Human Nutr Potsdam Rehbrucke, Dept Epidemiol, D-14558 Nuthetal, Germany.
   [Dierkes, Jutta] Otto Von Guericke Univ, Dept Clin Chem & Pathobiochem, Magdeburg, Germany.
   [Dierkes, Jutta] Univ Bergen, Inst Med, Fac Med & Dent, Bergen, Norway.
   [Klipstein-Grobusch, Kerstin] Univ Witwatersrand, Fac Hlth Sci, Sch Publ Hlth, Johannesburg, South Africa.
   [Moehlig, Matthias; Pfeiffer, Andreas F. H.; Spranger, Joachim] German Inst Human Nutr Potsdam Rehbrucke, Dept Clin Nutr, D-14558 Nuthetal, Germany.
   [Moehlig, Matthias; Pfeiffer, Andreas F. H.; Spranger, Joachim] Charite, Dept Endocrinol Diabet & Nutr, D-13353 Berlin, Germany.
C3 Leibniz Association; Deutsches Institut fur Ernahrungsforschung
   Potsdam-Rehbrucke (DIfE); Otto von Guericke University; University of
   Bergen; University of Witwatersrand; Leibniz Association; Deutsches
   Institut fur Ernahrungsforschung Potsdam-Rehbrucke (DIfE); Berlin
   Institute of Health; Free University of Berlin; Humboldt University of
   Berlin; Charite Universitatsmedizin Berlin
RP Drogan, D (corresponding author), German Inst Human Nutr Potsdam Rehbrucke, Dept Epidemiol, Arthur Scheunert Allee 114-116, D-14558 Nuthetal, Germany.
EM drogan@dife.de
RI Pfeiffer, Andreas/AAJ-2311-2020; Pischon, Tobias/HGE-8577-2022; Buijsse,
   Brian/E-5079-2011; Klipstein-Grobusch, Kerstin/F-5555-2016
OI Pischon, Tobias/0000-0003-1568-767X; Klipstein-Grobusch,
   Kerstin/0000-0002-5462-9889; Pfeiffer, Andreas F. H./0000-0002-6887-0016
FU Federal Ministry of Science of Germany [01 EA 9401]; European Union [SOC
   95201408 05F02]; German Cancer Aid [70-2488-Ha I]; European Community
   [SOC 98200769 05F02]; Federal Ministry of Education and Research
   [0312750B]; German Research Foundation [KFO192/1, 218/1, GK1208]; German
   Research Federal Ministry; Heisenberg-Professorship [SP716/1-1]
FX The recruitment phase of the EPIC-Potsdam Study was supported by the
   Federal Ministry of Science of Germany (01 EA 9401) and the European
   Union (SOC 95201408 05F02). The follow-up was supported by German Cancer
   Aid (70-2488-Ha I) and the European Community (SOC 98200769 05F02). The
   present study was supported by the Federal Ministry of Education and
   Research (0312750B), clinical research groups of the German Research
   Foundation (KFO192/1 and 218/1), a graduate school of the German
   Research Foundation (GK1208) (Drs Mohlig, Pfeiffer, and Spranger), the
   German Research Federal Ministry (Drs Pfeiffer and Spranger), and a
   Heisenberg-Professorship (SP716/1-1) (Dr Spranger).
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NR 36
TC 17
Z9 19
U1 0
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1079-5642
J9 ARTERIOSCL THROM VAS
JI Arterioscler. Thromb. Vasc. Biol.
PD OCT
PY 2010
VL 30
IS 10
BP 2053
EP 2058
DI 10.1161/ATVBAHA.110.209346
PG 6
WC Hematology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Hematology; Cardiovascular System & Cardiology
GA 650VV
UT WOS:000281882800027
PM 20671231
OA Bronze
DA 2025-06-11
ER

PT J
AU Kempf, K
   Rathmann, W
   Herder, C
AF Kempf, Kerstin
   Rathmann, Wolfgang
   Herder, Christian
TI Impaired glucose regulation and type 2 diabetes in children and
   adolescents
SO DIABETES-METABOLISM RESEARCH AND REVIEWS
LA English
DT Review
DE diabetes; glucose metabolism; risk factors; epidemiology; children;
   adolescents; paediatric
ID MIGRATION INHIBITORY FACTOR; COOPERATIVE HEALTH RESEARCH; AUGSBURG
   CASE-COHORT; METABOLIC SYNDROME PHENOTYPE; NUTRITION EXAMINATION SURVEY;
   CARDIOVASCULAR RISK-FACTORS; NECROSIS-FACTOR-ALPHA; BRITISH WOMENS
   HEART; BODY-MASS INDEX; AGE-OF-ONSET
AB Diabetes mellitus in paediatric patients used to be almost exclusively type 1, but in recent years, case series as well as hospital-based and population-based studies indicated that the number of children and adolescents with type 2 diabetes (T2DM) has been increasing. This development is alarming since T2DM in youth is usually not an isolated condition, but accompanied by other cardiovascular risk factors such as obesity, dyslipidaemia, hypertension and low-grade inflammation. In adults, numerous studies provided detailed data on prevalence, incidence and risk factors for the development of T2DM, but for children and adolescents clinical and experimental data are still rather limited. This review provides an overview about the epidemiology and pathogenesis of T2DM in youth and about impaired glucose regulation as major risk factor for diabetes development with a special focus on the recent literature on clinical and lifestyle-related risk factors. Differences in incidence and prevalence across different populations indicate that ethnic background and genetic pre-disposition may be important risk determinants. In addition, epigenetic factors and foetal programming appear to confer additional risk before birth. Among the environmental and lifestyle-related risk factors there is evidence that obesity, hypercaloric diet, physical inactivity, socio-economic position (SEP), smoking, low-grade inflammation, psychosocial stress and sleeping patterns contribute to the risk for T2DM. However, the assessment of the relevance of risk factors and of incidence or prevalence estimates in youth is complicated by methodological issues that are also discussed. Copyright (C) 2008 John Wiley & Sons, Ltd.
C1 [Kempf, Kerstin; Herder, Christian] Univ Dusseldorf, Inst Clin Diabet Res, German Diabet Ctr, Leibniz Inst, D-40225 Dusseldorf, Germany.
   [Rathmann, Wolfgang] Univ Dusseldorf, Leibniz Inst, German Diabet Ctr, Inst Biometr & Epidemiol, D-40225 Dusseldorf, Germany.
C3 Heinrich Heine University Dusseldorf; Leibniz Association; Deutsches
   Diabetes-Zentrum (DDZ); Heinrich Heine University Dusseldorf; Leibniz
   Association; Deutsches Diabetes-Zentrum (DDZ)
RP Herder, C (corresponding author), Univ Dusseldorf, Inst Clin Diabet Res, German Diabet Ctr, Leibniz Inst, Aufm Hennekamp 65, D-40225 Dusseldorf, Germany.
EM christian.herder@ddz.uni-duesseldorf.de
RI Qasrawi, Radwan/AAA-6245-2019
FU German Federal Ministry of Health and Social Security; Ministry of
   Science and Research of the State North Rhine-Westphalia
FX This work was supported by the German Federal Ministry of Health and
   Social Security, and the Ministry of Science and Research of the State
   North Rhine-Westphalia. We thank Dr. Hiltrud Merzenich for reading the
   manuscript critically and for helpful discussions.
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NR 135
TC 38
Z9 38
U1 0
U2 12
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1520-7552
EI 1520-7560
J9 DIABETES-METAB RES
JI Diabetes-Metab. Res. Rev.
PD SEP
PY 2008
VL 24
IS 6
BP 427
EP 437
DI 10.1002/dmrr.869
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 364YL
UT WOS:000260371600001
PM 18551709
DA 2025-06-11
ER

PT J
AU Sanal, MG
AF Sanal, Madhusudana Girija
TI The blind men 'see' the elephant-the many faces of fatty liver disease
SO WORLD JOURNAL OF GASTROENTEROLOGY
LA English
DT Review
DE nonalcoholic fatty liver disease; insulin resistance; lipid homeostasis;
   primate evolution; lipid channels; lipoprotein; adipokines; nuclear
   receptors; bile acid metabolism; personalized medicine
ID ACTIVATED-RECEPTOR-ALPHA; TRIGLYCERIDE TRANSFER PROTEIN; STEAROYL-COA
   DESATURASE-1; ELEMENT-BINDING PROTEIN; FARNESOID-X-RECEPTOR; DE-NOVO
   LIPOGENESIS; INSULIN-RESISTANCE; METABOLIC SYNDROME; ADIPOSE-TISSUE;
   HEPATIC STEATOSIS
AB Nonalcoholic fatty liver disease (NAFLD) is a group of diseases with excess fat in liver in the absence of a poorly defined limit of alcohol consumption. Most common variety, a universal public health problem, is associated with insulin resistance caused by a host of genetic and epigenetic defects modulated by life style and environmental factors. In fact the term NAFLD is loose to incorporate so many etiologies except alcoholism and few other etiologies, presenting as fat in liver. However as a sign fatty liver is very important in predicting the risk of diabetes, cardiovascular disease, stroke, cirrhosis and cancer. Abnormal fat accumulation can result from several defects in nuclear receptors associated with lipid sensing, synthesis and oxidation like LXR, FXR, SREBP, ChREBP and PPAR; defects in the lipid influx-efflux channels, insulin signaling, proteins involved in fatty acid catabolism, defects in adipose tissue development and function, inappropriate nutrition and finally defects in neural regulatory mechanisms. The progress of the disease is determined by the basic defects which results in fat accumulation, an individual's immunological response to the accumulated fat and its derivatives and the oxidant stress response. Congregation of unrelated genetic defects under same diagnosis 'NAFLD' can result in inefficient patient management. Further studies are required to understand the molecular basis of fatty liver to enable a personalized management of diseases presenting as fatty liver in the absence of alcohol abuse. (C) 2008 WJG. All rights reserved.
C1 Jawaharlal Nehru Univ, Special Ctr Mol Med, New Delhi 110067, India.
C3 Jawaharlal Nehru University, New Delhi
RP Sanal, MG (corresponding author), Jawaharlal Nehru Univ, Special Ctr Mol Med, New Delhi 110067, India.
EM sanalmg@gmail.com
RI Girija, Sanal/AAV-2072-2020
OI Madhusudana Girija, Sanal/0000-0003-0007-5718
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NR 135
TC 40
Z9 44
U1 0
U2 6
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 7041 Koll Center Parkway, Suite 160, PLEASANTON, CA, UNITED STATES
SN 1007-9327
EI 2219-2840
J9 WORLD J GASTROENTERO
JI World J. Gastroenterol.
PD FEB 14
PY 2008
VL 14
IS 6
BP 831
EP 844
DI 10.3748/wjg.14.831
PG 14
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 264IJ
UT WOS:000253280700003
PM 18240340
OA Green Published
DA 2025-06-11
ER

PT J
AU Towler, MC
   Hardie, DG
AF Towler, Mhairi C.
   Hardie, D. Grahame
TI AMP-activated protein kinase in metabolic control and insulin signaling
SO CIRCULATION RESEARCH
LA English
DT Review
DE calcium signaling; diabetes; insulin; metabolism; signaling pathways
ID ACETYL-COA CARBOXYLASE; FATTY-ACID OXIDATION; STIMULATED
   GLUCOSE-TRANSPORT; CELL-PERMEABLE ACTIVATOR; COENZYME-A CARBOXYLASE;
   PANCREATIC BETA-CELLS; SKELETAL-MUSCLE; RAT-LIVER;
   5-AMINOIMIDAZOLE-4-CARBOXAMIDE RIBONUCLEOSIDE; ENDOTHELIAL-CELLS
AB The AMP-activated protein kinase (AMPK) system acts as a sensor of cellular energy status that is conserved in all eukaryotic cells. It is activated by increases in the cellular AMP: ATP ratio caused by metabolic stresses that either interfere with ATP production (eg, deprivation for glucose or oxygen) or that accelerate ATP consumption ( eg, muscle contraction). Activation in response to increases in AMP involves phosphorylation by an upstream kinase, the tumor suppressor LKB1. In certain cells (eg, neurones, endothelial cells, and lymphocytes), AMPK can also be activated by a Ca2+- dependent and AMP-independent process involving phosphorylation by an alternate upstream kinase, CaMKK beta. Once activated, AMPK switches on catabolic pathways that generate ATP, while switching off ATP-consuming processes such as biosynthesis and cell growth and proliferation. The AMPK complex contains 3 subunits, with the alpha subunit being catalytic, the alpha subunit containing a glycogen-sensing domain, and the gamma subunits containing 2 regulatory sites that bind the activating and inhibitory nucleotides AMP and ATP. Although it may have evolved to respond to metabolic stress at the cellular level, hormones and cytokines such as insulin, leptin, and adiponectin can interact with the system, and it now appears to play a key role in maintaining energy balance at the whole body level. The AMPK system may be partly responsible for the health benefits of exercise and is the target for the antidiabetic drug metformin. It is a key player in the development of new treatments for obesity, type 2 diabetes, and the metabolic syndrome.
C1 Univ Dundee, Sir James Black Ctr, Coll Life Sci, Div Mol Physiol, Dundee DD1 5EH, Scotland.
C3 University of Dundee
RP Hardie, DG (corresponding author), Univ Dundee, Sir James Black Ctr, Coll Life Sci, Div Mol Physiol, Dow St, Dundee DD1 5EH, Scotland.
EM d.g.hardie@dundee.ac.uk
RI Hardie, David/Z-1979-2019
OI Towler, Mhairi/0009-0003-1830-1290; Hardie, Grahame/0000-0002-8373-7379
FU Wellcome Trust Funding Source: Medline
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NR 168
TC 1075
Z9 1231
U1 2
U2 234
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0009-7330
EI 1524-4571
J9 CIRC RES
JI Circ.Res.
PD FEB 16
PY 2007
VL 100
IS 3
BP 328
EP 341
DI 10.1161/01.RES.0000256090.42690.05
PG 14
WC Cardiac & Cardiovascular Systems; Hematology; Peripheral Vascular
   Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Hematology
GA 137DU
UT WOS:000244274000007
PM 17307971
OA Bronze
DA 2025-06-11
ER

PT J
AU Chen, HM
   Liu, ZH
   Zeng, CH
   Li, SJ
   Wang, QW
   Li, LS
AF Chen, Hui-Mei
   Liu, Zhi-Hong
   Zeng, Cai-Hong
   Li, Shi-Jun
   Wang, Qing-Wen
   Li, Lei-Shi
TI Podocyte lesions in patients with obesity-related glomerulopathy
SO AMERICAN JOURNAL OF KIDNEY DISEASES
LA English
DT Article
DE obesity-related glomerulopathy; podocyte; proteinuria
ID DIABETIC-NEPHROPATHY; METABOLIC SYNDROME; MECHANICAL-STRESS;
   RENAL-DISEASE; PREVALENCE; NUMBER; INJURY; ADULTS; GLOMERULOSCLEROSIS;
   ALBUMINURIA
AB Background: Obesity-related glomerulopathy is an important complication of obesity that shares some pathophysiological factors relevant to renal damage with diabetic nephropathy. It was recognized that podocyte lesions lead to proteinuria and glomerulosclerosis in patients with some proteinuric glomerular diseases, especially diabetic nephropathy. However, podocyte changes in patients with obesity-related glomerulopathy and the underlying mechanisms are unclear. Methods: Glomerular volume, podocyte number, and foot-process width were evaluated in 46 patients with biopsy-proven obesity-related glomerulopathy. Renal tissue from 10 kidney donors served as controls. Results: Glomerular volume was enlarged markedly in patients with obesity-related glomerulopathy (P < 0.001), with a corresponding decrease in podocyte density (P < 0.001) compared with controls. Foot-process width on the peripheral glomerular basement membrane was increased significantly, whereas mesangial volume fraction did not differ between patients with obesity-related glomerulopathy and controls. Degree of proteinuria was associated strongly with decreased podocyte density (P = 0.001), increased foot-process width (P = 0.001), and decreased podocyte number (P = 0.002). In addition, the endogenous creatinine clearance rate correlated with decreased podocyte number (P = 0.008). Interestingly, podocyte number and density correlated significantly with abnormalities in fasting glucose (P < 0.001) and insulin levels (P < 0.001) and Homeostasis Model Assessment of Insulin Resistance (P < 0.001). Conclusion: Decreased podocyte density and number were observed in patients with obesity-related glomerulopathy, and changes in podocytes correlated with degree of proteinuria and renal function impairment in these patients. In addition to the enlargement in glomerular volume with consequential mechanical stretch, metabolic disorders also may contribute to the development of podocyte lesions in patients with obesity-related glomerulopathy.
C1 Nanjing Univ, Sch Med, Jinling Hosp, Res Inst Nephrol, Nanjing 210002, Peoples R China.
C3 Nanjing University
RP Liu, ZH (corresponding author), Nanjing Univ, Sch Med, Jinling Hosp, Res Inst Nephrol, Nanjing 210002, Peoples R China.
EM zhihong@21cn.net
RI Li, Huaming/GZG-6983-2022
OI Liu, Zhi-Hong/0000-0001-6093-0726; Chen, Huimei/0000-0001-7788-1334
CR [Anonymous], International Association for the Study of Obesity (IASO)
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NR 33
TC 158
Z9 175
U1 0
U2 18
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0272-6386
J9 AM J KIDNEY DIS
JI Am. J. Kidney Dis.
PD NOV
PY 2006
VL 48
IS 5
BP 772
EP 779
DI 10.1053/j.ajkd.2006.07.025
PG 8
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 197FV
UT WOS:000248540900009
PM 17059996
DA 2025-06-11
ER

PT J
AU Hales, CN
   Ozanne, SE
AF Hales, CN
   Ozanne, SE
TI The dangerous road of catch-up growth
SO JOURNAL OF PHYSIOLOGY-LONDON
LA English
DT Article; Proceedings Paper
CT 49th Annual Meeting of the Society-for-Gynecologic-Investigation
CY MAR 19-23, 2002
CL Los Angeles, CA
SP Soc Gynecol Invest
ID DEPENDENT DIABETES-MELLITUS; LOW-BIRTH-WEIGHT; GLUCOSE-TOLERANCE;
   INSULIN; PROTEIN; FETAL; PREGNANCY; OBESITY; HYPERTENSION; EXPRESSION
AB Many epidemiological studies have now shown a strongly increased risk of developing type 2 diabetes and the metabolic syndrome in adults who as neonates showed signs of poor early (fetal and early postnatal) growth. The thrifty phenotype hypothesis was proposed to provide a conceptual and experimentally testable basis of these relationships. We have used protein restriction of rat dams, as a means to test this hypothesis. In vivo and in vitro studies of the growth-restricted offspring of such pregnancies have provided findings showing remarkable parallels with the human conditions. Permanent changes in the expression of regulatory proteins in liver, muscle and adipose tissue provide at least part of the explanation of the changes observed and offer potential markers for testing in the human context. These studies have also raised the question as to whether 'catch up' growth following early growth retardation may add to the risks posed by this early handicap. Male rats growth-retarded during fetal life and cross-fostered shortly after birth to normal lactating dams reach normal body and organ weights by weaning but have a reduced longevity. This finding raises the possibility that catch up growth, whilst potentially beneficial in the short term, may be detrimental to long-term survival. Human epidemiological studies may point in the same direction. Work by others on other models of early growth restriction have produced similar, although more limited, data. These findings raise the interesting possibility that the response to fetal stress, be it nutritional or other, may evoke a somewhat restricted and uniform pattern of adaptive response.
C1 Univ Cambridge, Dept Clin Biochem, Cambridge, England.
C3 University of Cambridge
RP Univ Cambridge, Dept Clin Biochem, Cambridge, England.
EM cnh1000@cam.ac.uk
OI Ozanne, Susan/0000-0001-8753-5144
CR ARNER P, 1999, P BRIT HYP ASS SCI W
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NR 39
TC 184
Z9 210
U1 1
U2 15
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-3751
EI 1469-7793
J9 J PHYSIOL-LONDON
JI J. Physiol.-London
PD FEB 15
PY 2003
VL 547
IS 1
BP 5
EP 10
DI 10.1113/jphysiol.2002.024406
PG 6
WC Neurosciences; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Neurosciences & Neurology; Physiology
GA 690VD
UT WOS:000183570400004
PM 12562946
OA Green Published
DA 2025-06-11
ER

PT J
AU Ciardullo, S
   Perseghin, G
AF Ciardullo, Stefano
   Perseghin, Gianluca
TI From NAFLD to MAFLD and MASLD: a tale of alcohol, stigma and metabolic
   dysfunction
SO METABOLISM AND TARGET ORGAN DAMAGE
LA English
DT Article
ID FATTY LIVER-DISEASE; HOMEOSTASIS MODEL ASSESSMENT; GLUCOSE CLAMP
   TECHNIQUE; ALL-CAUSE MORTALITY; INSULIN-RESISTANCE; TRANSIENT
   ELASTOGRAPHY; FIBROSIS STAGE; UNITED-STATES; NONALCOHOLIC
   STEATOHEPATITIS; HEPATOCELLULAR-CARCINOMA
AB Liver steatosis is a frequent finding in clinical practice and it is estimated to affect 30% of the general adult population worldwide. It became one of the leading causes of end-stage liver disease and hepatocellular carcinoma. From its first description, a diagnosis of nonalcoholic fatty liver disease (NAFLD) required the exclusion of excessive alcohol consumption and concomitant chronic liver diseases of different origins, making it a diagnosis of exclusion. In recent years, the need to stress the strict association between liver steatosis and metabolic dysfunction (i.e., insulin resistance, overweight/obesity, type 2 diabetes, and metabolic syndrome), as well as the desire to define a condition in a positive rather than negative way, led to new definitions and new diagnostic criteria. Metabolic dysfunction-associated fatty liver disease (MAFLD) was proposed by Eslam et al. in 2020. More recently, a Delphi consensus endorsed by several international hepatologic societies proposed a new terminology [metabolic dysfunction-associated steatotic liver disease (MASLD)] and a new set of diagnostic criteria. The MAFLD and MASLD definitions have a good degree of concordance. They mainly differ in the number of metabolic derangements needed to define "metabolic dysfunction" in normal-weight individuals and in alcohol consumption. Indeed, while MAFLD does not exclude patients with significant alcohol consumption, the recent Delphi consensus included the metabolic dysfunction and alcohol-related liver disease (MetALD) disease entity, a condition in which steatosis, metabolic dysfunction, and moderate alcohol intake coexist. In the present narrative review, we underline the strengths and possible limitations of each definition and summarize available evidence from epidemiologic studies evaluating the clinical usefulness of each set of diagnostic criteria.
C1 [Ciardullo, Stefano; Perseghin, Gianluca] Policlin Monza, Dept Med & Rehabil, Via Modigliani 10, I-20900 Monza, Italy.
   [Ciardullo, Stefano; Perseghin, Gianluca] Univ Milano Bicocca, Sch Med & Surg, I-20900 Milan, Italy.
C3 University of Milano-Bicocca
RP Ciardullo, S (corresponding author), Policlin Monza, Dept Med & Rehabil, Via Modigliani 10, I-20900 Monza, Italy.
EM stefano.ciardullo@unimib.it
RI Ciardullo, Stefano/AAE-4672-2020
OI Ciardullo, Stefano/0000-0003-2422-3041
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NR 115
TC 3
Z9 3
U1 1
U2 3
PU OAE PUBLISHING INC
PI ALHAMBRA
PA 245 E MAIN ST, ST122, ALHAMBRA, CA 91801 USA
EI 2769-6375
J9 METAB TARGET ORGAN D
JI Metab. Target Organ Damage
PD DEC
PY 2024
VL 4
IS 4
AR 30
DI 10.20517/mtod.2024.39
PG 14
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA J3T7X
UT WOS:001336327400004
OA gold
DA 2025-06-11
ER

PT J
AU Mesmar, F
   Muhsen, M
   Mirchandani, R
   Tourigny, JP
   Tennessen, JM
   Bondesson, M
AF Mesmar, Fahmi
   Muhsen, Maram
   Mirchandani, Rachna
   Tourigny, Jason P.
   Tennessen, Jason M.
   Bondesson, Maria
TI The herbicide acetochlor causes lipid peroxidation by inhibition of
   glutathione peroxidase activity
SO TOXICOLOGICAL SCIENCES
LA English
DT Article
DE zebrafish; adipogenesis; ferroptosis; transcriptomics; lipidomics
ID OXIDATIVE STRESS; GENE-EXPRESSION; ZEBRAFISH; CELL; DIFFERENTIATION;
   QUANTIFICATION; IDENTIFICATION; ACCUMULATION; FERROPTOSIS; DISRUPTION
AB Metabolic syndrome is increasing worldwide, particularly in rural communities, where residents have a higher risk of exposure to pesticides. We investigated whether six commonly used agricultural pesticides on corn and soy fields possess adipogenic and metabolic disruption activity. Exposure to two of these pesticides, the herbicides acetochlor and metolachlor, induced adipogenesis in vitro in mouse 3T3-L1 preadipocytes. The most potent compound, acetochlor, was selected for further studies in zebrafish. Acetochlor exposure induced morphological malformations and lethality in zebrafish larvae with an EC50 of 7.8 mu M and LC50 of 12 mu M. Acetochlor exposure at 10 nM resulted in lipid accumulation in zebrafish larvae when simultaneously fed a high-cholesterol diet. To decipher the molecular mechanisms behind acetochlor action, we performed transcriptomic and lipidomic analyses of exposed animals. The combined omics results suggested that acetochlor exposure increased Nrf2 activity in response to reactive oxygen species, as well as induced lipid peroxidation and ferroptosis. We further discovered that acetochlor structurally shares a chloroacetamide group with known inhibitors of glutathione peroxidase 4 (GPX4). Computational docking analysis suggested that acetochlor covalently binds to the active site of GPX4. Consistent with this prediction, Gpx activity was efficiently repressed by acetochlor in zebrafish, whereas lipid peroxidation was increased. We propose that acetochlor disrupts lipid homeostasis by inhibiting GPX activity, resulting in the accumulation of lipid peroxidation, 4-hydroxynonenal, and reactive oxygen species, which in turn activate Nrf2. Because metolachlor, among other acetanilide herbicides, also contains the chloroacetamide group, inhibition of GPX activity may represent a novel, common molecular initiating event of metabolic disruption.
C1 [Mesmar, Fahmi; Muhsen, Maram; Mirchandani, Rachna; Bondesson, Maria] Indiana Univ, Dept Intelligent Syst Engn, Multidisciplinary Engn & Sci Hall,2425 N Milo B Sa, Bloomington, IN 47408 USA.
   [Tourigny, Jason P.; Tennessen, Jason M.] Indiana Univ, Dept Biol, Bloomington, IN 47405 USA.
C3 Indiana University System; Indiana University Bloomington; Indiana
   University System; Indiana University Bloomington
RP Bondesson, M (corresponding author), Indiana Univ, Dept Intelligent Syst Engn, Multidisciplinary Engn & Sci Hall,2425 N Milo B Sa, Bloomington, IN 47408 USA.
EM mbondess@iu.edu
RI Tennessen, Jason/I-1937-2019
OI Tennessen, Jason/0000-0002-3527-5683; Mirchandani,
   Rachna/0000-0002-3873-9746
FU Indiana Clinical and Translational Sciences Institute; National
   Institutes of HealthNational Center for Advancing Translational
   Sciences, Clinical and Translational Sciences Award [TL1TR002531];
   European Union [965406]
FX This work was supported by grants from the Indiana Clinical and
   Translational Sciences Institute, which is funded in part by award
   number TL1TR002531 from the National Institutes of Health, the National
   Center for Advancing Translational Sciences, Clinical and Translational
   Sciences Award, and the European Union's Horizon 2020 Research and
   Innovation Programme under grant agreement no. 965406 (PrecisionTox).
   The work presented in this publication was performed as part of the
   "Animal-free Safety assessment of chemicals: Project cluster for
   Implementation of novel Strategies" (ASPIS). The results and conclusions
   reflect only the authors' views, and the funding agencies cannot be held
   responsible for any use that may be made of the information contained
   herein.
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NR 94
TC 1
Z9 1
U1 6
U2 11
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1096-6080
EI 1096-0929
J9 TOXICOL SCI
JI Toxicol. Sci.
PD SEP 17
PY 2024
VL 202
IS 2
DI 10.1093/toxsci/kfae113
EA SEP 2024
PG 13
WC Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Toxicology
GA N2E7E
UT WOS:001314138000001
PM 39240656
DA 2025-06-11
ER

PT J
AU Navabi, M
   Rahbardar, MG
   Mehri, S
   Hosseinzadeh, H
AF Navabi, Mahboobeh
   Rahbardar, Mahboobeh Ghasemzadeh
   Mehri, Soghra
   Hosseinzadeh, Hossein
TI Attenuation of acrylamide-induced neurotoxicity by supplementation of
   sitagliptin in Wistar rats
SO IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
LA English
DT Article
DE Anti-oxidants; Caspases; Glutathione; Inflammation; Malondialdehyde;
   Neurotoxicity syndromes; Tumor necrosis factors
ID METABOLIC SYNDROME; ACTIVATION; APOPTOSIS; HEPATOTOXICITY
AB Objective(s): Acrylamide (ACR) induces neurotoxicity in humans and animals through different mechanisms. Sitagliptin is a type-2 diabetes medication with neuroprotective properties. The effects of sitagliptin against neurotoxicity stimulated by ACR were examined. Materials and Methods: Male Wistar rats were classified as follows: 1. Control (normal saline, 11 days, IP), 2. ACR (50 mg/kg, 11 days, IP), 3. ACR (11 days, days 11-20 normal saline), 4-7. ACR+sitagliptin (5, 10, 20, and 40 mg/kg, 11 days, IP), 8. ACR+sitagliptin (10 mg/kg, days 6-11), 9. ACR+sitagliptin (10 mg/kg, days 6-20), 10. Sitagliptin (40 mg/kg, 11 days), 11. ACR+vitamin E (200 mg/kg, IP). Finally, the gait score was evaluated. Reduced glutathione (GSH) and malondialdehyde (MDA) levels were measured in cortex tissue. Also, IL-1 beta, TNF-alpha, and caspase-3 levels were assessed in the cortex by western blotting. Results: ACR caused movement disorders, triggered oxidative stress, and raised TNF-alpha, IL-1 beta, and caspase-3 cleaved levels. Supplementation of sitagliptin (10 mg/kg) along with ACR, in 3 protocols, reduced gait disorders compared to the ACR group. Receiving sitagliptin in all doses plus ACR and injection of sitagliptin (10 mg/kg) from days 6 to11 reduced the MDA level of cortex tissue. Sitagliptin (all doses) plus ACR increased the GSH level of the cortex tissue. Sitagliptin (10 mg/kg) with ACR dropped the amounts of TNF-alpha and caspase-3 cleaved proteins in cortex tissue but did not affect the IL-1 beta level. Conclusion: Sitagliptin disclosed preventive and therapeutic effects on ACR neurotoxicity. Sitagliptin possesses antioxidant, anti-inflammatory, and anti-apoptotic properties and inhibits CR neurotoxicity in rats.
C1 [Navabi, Mahboobeh; Mehri, Soghra; Hosseinzadeh, Hossein] Mashhad Univ Med Sci, Sch Pharm, Dept Pharmacodynam & Toxicol, Mashhad, Iran.
   [Rahbardar, Mahboobeh Ghasemzadeh; Mehri, Soghra; Hosseinzadeh, Hossein] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Pharmaceut Res Ctr, Mashhad, Iran.
C3 Mashhad University of Medical Sciences; Mashhad University of Medical
   Sciences
RP Hosseinzadeh, H (corresponding author), Mashhad Univ Med Sci, Sch Pharm, Dept Pharmacodynam & Toxicol, Mashhad, Iran.; Hosseinzadeh, H (corresponding author), Mashhad Univ Med Sci, Pharmaceut Technol Inst, Pharmaceut Res Ctr, Mashhad, Iran.
EM HosseinzadehH@mums.ac.ir
RI mehri, soghra/P-2939-2018; Ghasemzadeh Rahbardar, Mahboobeh/V-4452-2019;
   Hosseinzadeh, Hossein/F-3013-2010
OI Ghasemzadeh Rahbardar, Mahboobeh/0000-0002-5491-572X
FU Mashhad University of Medical Sciences [985001]
FX <STRONG> </STRONG>The results presented in this paper were part of a
   student thesis. The authors are thankful to Mashhad University of
   Medical Sciences for financial support (grant No: 985001) .
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NR 48
TC 2
Z9 2
U1 0
U2 1
PU MASHHAD UNIV MED SCIENCES
PI MASHHAD
PA VICE-CHANCELLOR FOR RES CTR OFF IJBMS, DANESHGAH ST, PO BOX 9138813944 -
   445, MASHHAD, 00000, IRAN
SN 2008-3866
EI 2008-3874
J9 IRAN J BASIC MED SCI
JI Iran. J. Basic Med. Sci.
PD MAR
PY 2024
VL 27
IS 3
BP 311
EP 318
DI 10.22038/IJBMS.2023.73187.15905
PG 8
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA IH2F6
UT WOS:001165364900005
PM 38333747
DA 2025-06-11
ER

PT J
AU Phimarn, W
   Sungthong, B
   Wichiyo, K
AF Phimarn, Wiraphol
   Sungthong, Bunleu
   Wichiyo, Kittisak
TI Effect of Cynara scolymus L. on Cardiometabolic Outcomes: An
   Updated Meta-analysis of Randomized Controlled Trials and
   Meta-regression
SO PHARMACOGNOSY MAGAZINE
LA English
DT Review
DE Blood glucose; lipid profile; blood pressure; anthropometric parameters;
   artichoke; Cynara scolymus
ID ARTICHOKE LEAF EXTRACT; DOUBLE-BLIND; METABOLIC SYNDROME; OXIDATIVE
   STRESS; SUPPLEMENTATION; CHOLESTEROL; TCF7L2-RS7903146; PARAMETERS;
   LIVER
AB Background: Artichoke (Cynara scolymus L.) has the potential to treat diabetes, dyslipidemia, hypertension, and obesity. However, the evidence from previous studies is not consistent.Objectives: This meta-analysis evaluated the efficacy of products derived from artichokes on blood glucose, lipid level, blood pressure, and anthropometric parameters.Methodology: The literature was reviewed via international databases (PubMed, ScienceDirect, and Scopus). A total of 21 RCTs with high quality, assessed by the Cochrane risk-of-bias tool, were included.Results: Artichoke was linked to a significant reduction in fasting blood sugar (FBS) (WMD: -3.76 mg/dL: 95%CI -7.31, -0.22), insulin level (WMD: -1.35 mIU/L: 95%CI -2.29, -0.41), and HOMA-IR (WMD: -1.00: 95%CI -1.95, -0.06). Similar results were observed for LDL-c (WMD: -12.94 mg/dL: 95%CI -18.02, -7.87), total cholesterol (TC) (WMD: -19.64 mg/dL: 95%CI -23.94, -15.35), and triglyceride (TG) (WMD: -13.36 mg/dL: 95%CI -19.06, -7.66). Moreover, participants who administered artichoke experienced a significant reduction in SBP (WMD: -1.59 mmHg: 95%CI -3.02, -0.16), body weight (BW) (WMD: -1.17 kg: 95%CI -1.75, -0.60), and BMI (WMD: -0.30 kg/m2: 95%CI -3.02, -0.16).Conclusion: Artichoke may improve blood glucose, lipid profile, blood pressure, and anthropometric parameters. A large, well-designed RCT and head-to-head comparison using a standardized preparation of artichoke will provide definitive data on specific participants.
C1 [Phimarn, Wiraphol] Mahasarakham Univ, Fac Pharm, Dept Clin Pharm, Kantharawichai, Maha Sarakham, Thailand.
   [Phimarn, Wiraphol] Mahasarakham Univ, Fac Pharm, Social Pharm Res Unit, Kantharawichai, Maha Sarakham, Thailand.
   [Sungthong, Bunleu] Mahasarakham Univ, Fac Pharm, Dept Pharmaceut Sci, Kantharawichai, Maha Sarakham, Thailand.
   [Sungthong, Bunleu] Mahasarakham Univ, Fac Pharm, Integrat Pharmaceut & Innovat Pharmaceut Technol, Kantharawichai, Maha Sarakham, Thailand.
   [Wichiyo, Kittisak] Somdej Hosp, Dept Pharm, Somdej Kalasin, Thailand.
C3 Mahasarakham University; Mahasarakham University; Mahasarakham
   University; Mahasarakham University
RP Phimarn, W (corresponding author), Mahasarakham Univ, Fac Pharm, Dept Clin Pharm, Kantharawichai 44150, Maha Sarakham, Thailand.; Phimarn, W (corresponding author), Mahasarakham Univ, Fac Pharm, Social Pharm Res Unit, Kantharawichai 44150, Maha Sarakham, Thailand.
EM wiraphol.p@msu.ac.th
RI Sungthong, Bunleu/AAB-7907-2019
OI Sungthong, Bunleu/0000-0001-8697-0718; Phimarn,
   Wiraphol/0000-0002-9255-1074
FU Mahasarakham University [2566]
FX This research project was financially supported by Mahasarakham
   University (Grant Number 2566).
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NR 50
TC 2
Z9 2
U1 1
U2 3
PU SAGE PUBLICATIONS INDIA  PVT LTD
PI NEW DELHI
PA B-1-I-1 MOHAN CO-OPERATIVE INDUSTRIAL AREA, MATHURA RD, POST BAG NO 7,
   NEW DELHI 110 044, INDIA
SN 0973-1296
EI 0976-4062
J9 PHARMACOGN MAG
JI Pharmacogn. Mag.
PD JUN
PY 2024
VL 20
IS 2
BP 372
EP 388
DI 10.1177/09731296231217557
EA JAN 2024
PG 17
WC Chemistry, Medicinal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA OA8S7
UT WOS:001142836500001
OA hybrid
DA 2025-06-11
ER

PT J
AU Zhang, Y
   Wang, RN
   Tan, HL
   Wu, KL
   Hu, YJ
   Diao, HT
   Wang, DW
   Tang, XY
   Leng, MY
   Li, X
   Cai, ZL
   Luo, DS
   Shao, XQ
   Yan, ML
   Chen, YY
   Rong, XL
   Guo, J
AF Zhang, Yue
   Wang, Ruonan
   Tan, Huiling
   Wu, Kaili
   Hu, Yaju
   Diao, Hongtao
   Wang, Dongwei
   Tang, Xinyuan
   Leng, Mingyang
   Li, Xu
   Cai, Zhenlu
   Luo, Duosheng
   Shao, Xiaoqi
   Yan, Meiling
   Chen, Yingyu
   Rong, Xianglu
   Guo, Jiao
TI Fufang Zhenzhu Tiaozhi (FTZ) capsule ameliorates diabetes-accelerated
   atherosclerosis via suppressing YTHDF2-mediated m6A modification of
   SIRT3 mRNA
SO JOURNAL OF ETHNOPHARMACOLOGY
LA English
DT Article
DE Fufang Zhenzhu TiaoZhi; Diabetes-accelerated atherosclerosis; m 6 A RNA
   methylation; YTHDF2; SIRT3
ID APOPTOSIS; DISEASE; KEAP1; SERUM; GENE
AB Ethnopharmacological relevance: Fufang Zhenzhu TiaoZhi (FTZ), a Chinese medicinal decoction, has continuously been used to treat metabolic syndrome. Atherosclerosis is the main pathological basis of cardiovascular disease. The N6 methyladenosine (m6A) modification is a highly dynamic and reversible process involving a variety of important biological processes.Aim of the study: Here, we investigated the therapeutic effects and mechanism of FTZ in diabetes-accelerated atherosclerosis.Materials and methods: Doppler ultrasonography was used to examine the carotid intima-media thickness and plaque area in diabetic atherosclerosis patients. HFD mice were injected with streptozotocin to induce diabetes. HE and Oil red O staining were used to assess the effect of FTZ on lipid deposition. HUVECs were induced with HG/ox-LDL as a model of diabetic atherosclerosis. Furthermore, application of m6A methylation level kit, qRTPCR, Western blot, tunel staining, reactive oxygen species staining and mPTP staining were performed to analyze the detailed mechanism. Results: Clinical trials of FTZ have shown obvious effect of lowering blood glucose and blood lipids. These effects were reversed after FTZ intervention. Compared with the control, lipid deposition decreased significantly after FTZ administration. FTZ reduced endothelial cell apoptosis. At the same time, we found that FTZ reversed the increase of methylation reader YTHDF2 caused by ox-LDL treatment. Subsequently, we discovered that YTHDF2 degraded SIRT3 mRNA, leading to endothelial cell apoptosis and oxidative stress.Conclusion: FTZ attenuated diabetes-accelerated atherosclerosis by decreasing blood glucose and serum lipids levels, and increased endothelial cell antioxidant capacity, inhibited endothelial cell apoptosis via inhibiting YTHDF2-mediated m6A modification of SIRT3 mRNA, which reduced mRNA degradation.
C1 [Zhang, Yue; Wang, Ruonan; Tan, Huiling; Wu, Kaili; Hu, Yaju; Diao, Hongtao; Wang, Dongwei; Tang, Xinyuan; Leng, Mingyang; Li, Xu; Cai, Zhenlu; Luo, Duosheng; Shao, Xiaoqi; Yan, Meiling; Chen, Yingyu; Rong, Xianglu; Guo, Jiao] Guangdong Pharmaceut Univ, Guangdong Metab Dis Res Ctr Integrated Chinese & W, Key Lab Glucolipid Metab Disorder, Minist Educ China,Inst Chinese Med,Guangdong TCM K, Guangzhou 510006, Peoples R China.
   [Chen, Yingyu] Guangdong Pharmaceut Univ, Affiliated Hosp, Guangzhou 510080, Peoples R China.
   [Guo, Jiao] Guangdong Pharmaceut Univ, Guangzhou Higher Educ Mega Ctr, 280 Wai Huan Dong Rd, Guangzhou 510006, Peoples R China.
C3 Guangdong Pharmaceutical University; Ministry of Education - China;
   Guangdong Pharmaceutical University; Guangdong Pharmaceutical University
RP Guo, J (corresponding author), Guangdong Pharmaceut Univ, Guangzhou Higher Educ Mega Ctr, 280 Wai Huan Dong Rd, Guangzhou 510006, Peoples R China.
EM zhangyue@gdpu.edu.cn; 1142771845@qq.com; 1258792297@qq.com;
   1521838308@qq.com; 1035558584@qq.com; diaohongtao@gdpu.edu.cn;
   1179399063@qq.com; 2419975731@qq.com; 781523977@qq.com;
   1465630263@qq.com; 1622474908@qq.com; lds0901@163.com;
   shaoxiaoqi@gdpu.edu.cn; yanmeiling0122@gdpu.edu.cn; 17287424@qq.com;
   xl_rong@qq.com; gyguoyz@163.com
RI Diao, Dht/HCG-9725-2022; shao, xiaoqi/AFZ-7753-2022; Bei,
   Weijian/K-5208-2015; zhang, yingzi/KXR-6143-2024; Tan,
   Hui/AAZ-3987-2021; Wang, Dongwei/M-7768-2017
FU Key Project of National Natural Science Foundation of China [81830113];
   National key R amp; D pro-gram of China "Research on modernization of
   traditional Chinese med-icine" [2018YFC1704200]; Major basic applied
   basic research projects of Guangdong Province of China [2019B030302005];
   Youth Innovation Talents Project of Colleges and Universities in
   Guangdong Province [2019KQNCX058]
FX Funding This work was supported by the Key Project of National Natural
   Science Foundation of China (81830113) ; the National key R & D pro-gram
   of China "Research on modernization of traditional Chinese med-icine"
   (2018YFC1704200) and Major basic applied basic research projects of
   Guangdong Province of China (2019B030302005) and the Youth Innovation
   Talents Project of Colleges and Universities in Guangdong Province
   (2019KQNCX058) .
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NR 46
TC 11
Z9 11
U1 3
U2 17
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0378-8741
EI 1872-7573
J9 J ETHNOPHARMACOL
JI J. Ethnopharmacol.
PD DEC 5
PY 2023
VL 317
AR 116766
DI 10.1016/j.jep.2023.116766
EA JUN 2023
PG 12
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA M4QB1
UT WOS:001030060700001
PM 37343655
OA hybrid
DA 2025-06-11
ER

PT J
AU González-Delgado, A
   Fariña-Hernández, A
   Marrero, D
   Franco-Maside, A
   Hernández-Barroso, G
   Perez-Carreño, E
   Acosta-Sorensen, C
   Rodríguez-Rodríguez, AE
   Collantes, T
   Rodríguez-Muñoz, A
   Rodriguez-Alvarez, C
   Rivero, A
   Sosa, AJ
   Macía, M
   García, ET
   Alvarez-Gonzalez, A
   Rinne, AG
   Rodríguez-Hernández, A
   De Bonis-Redondo, E
   Adanero, CR
   Hernández, D
   Ramírez, AT
   Porrini, E
AF Gonzalez-Delgado, Alejandra
   Farina-Hernandez, Arminda
   Marrero, Domingo
   Franco-Maside, Andres
   Hernandez-Barroso, Grimanesa
   Perez-Carreno, Estefania
   Acosta-Sorensen, Cristian
   Rodriguez-Rodriguez, Ana Elena
   Collantes, Tatiana
   Rodriguez-Munoz, Ana, I
   Rodriguez-Alvarez, Carla
   Rivero, Antonio
   Sosa, Alejandro Jimenez
   Macia, Manuel
   Garcia, Elena Teran
   Alvarez-Gonzalez, Alejandra
   Rinne, Ana Gonzalez
   Rodriguez-Hernandez, Aurelio
   De Bonis-Redondo, Eduardo
   Adanero, Concepcion Rodriguez
   Hernandez, Domingo
   Ramirez, Armando Torres
   Porrini, Esteban
TI Inflammation on the waiting list is a risk factor for new-onset
   prediabetes and post-transplant diabetes mellitus: a prospective study.
SO NEPHRON
LA English
DT Article
ID INSULIN-RESISTANCE; TRANSPLANT RECIPIENTS; METABOLIC SYNDROME; OXIDATIVE
   STRESS; TYPE-2; SENSITIVITY; ASSOCIATION; BIOMARKERS; CYTOKINES; MARKERS
AB Introduction: Inflammation is a risk factor for diabetes in the general population. The role of inflammation in prediabetes or post-transplant diabetes (PTDM) is not clear. We evaluated the association between inflammatory markers in patients on the waiting list for renal transplantation and the onset of prediabetes and PTDM 12 months after transplantation.Methods: This is a post-hoc analysis of a prospective study, that included non-diabetic patients on the waiting list for kidney transplantation who underwent an oral glucose tolerance test (OGTT) and were followed up to 12 months after transplantation. At this time, those patients without PTDM underwent another OGTT. At pretransplant five cytokines: TNF alpha, IL6, IL1 beta, CRP, MCP1 were determined. The association between inflammation and prediabetes/PTDM was evaluated using multiple regression models.Results: 110 patients on the waiting list were enroled: 74 had normal glucose metabolism and 36 had prediabetes or occult diabetes. At 12 months, 53 patients had normal glucose metabolism, 25 prediabetes and 32 PTDM. In multiple regression analysis, pre-transplant inflammation was not a risk factor for prediabetes or PTDM. This was attributed to the high interrelation between obesity, prediabetes and inflammation: about 75% of the cases had these conditions. In a sub-analysis we analysed only patients without prediabetes and occult diabetes on the waiting list and found that TNF alpha levels and BMI at pre-transplant were independently associated with the onset of prediabetes or PTDM one year after transplantation.Conclusions: Pre-transplant inflammation and BMI are risk factors for prediabetes and PTDM in patients without glucose metabolism alterations.
C1 [Gonzalez-Delgado, Alejandra] Hosp Univ Canarias HUC, Newborn Screening Unit, Cent Lab, Tenerife, Spain.
   [Farina-Hernandez, Arminda; Marrero, Domingo; Acosta-Sorensen, Cristian; Sosa, Alejandro Jimenez; Garcia, Elena Teran; Alvarez-Gonzalez, Alejandra; Rinne, Ana Gonzalez; Rodriguez-Hernandez, Aurelio; De Bonis-Redondo, Eduardo; Adanero, Concepcion Rodriguez; Ramirez, Armando Torres; Porrini, Esteban] Hosp Univ Canarias, Nephrol Unit, Tenerife, Spain.
   [Franco-Maside, Andres] Hosp Univ Canarias HUC, Immunol Unit, Cent Lab, Tenerife, Spain.
   [Perez-Carreno, Estefania] HUC, Res Unit, Tenerife, Spain.
   [Collantes, Tatiana] Pontificia Univ Catolica Chile, Hosp Clin, Santiago, Spain.
   [Rodriguez-Munoz, Ana, I; Rodriguez-Alvarez, Carla; Rivero, Antonio; Macia, Manuel] Hosp Univ NS La Candelaria, Nephrol Serv, Tenerife, Spain.
   [Hernandez, Domingo] Univ Malaga, Hosp Reg Univ Malaga, Nephrol Serv, IBIMA, Malaga, Spain.
   [Ramirez, Armando Torres; Porrini, Esteban] Univ La Laguna, Inst Tecnol Biomed ITB, Tenerife, Spain.
C3 Universidad de la Laguna; University Hospital of the Canary Islands;
   Universidad de la Laguna; University Hospital of the Canary Islands;
   Instituto de Investigacion Biomedica de Malaga y Plataforma en
   Nanomedicina (IBIMA); Universidad de Malaga; Universidad de la Laguna
RP Porrini, E (corresponding author), Hosp Univ Canarias, Res Unit, Ofra S-N, San Cristobal la Laguna 38320, SC De Tenerife, Spain.
EM estebanporrini72@hotmail.com
RI Jimenez-Abizanda, Ana/L-1676-2014; Hernandez, Domingo/R-4041-2019
OI Farina Hernandez, Arminda/0009-0002-9333-241X; Gonzalez Delgado,
   Alejandra/0000-0002-1561-9231
FU Instituto de Salud Carlos III [FIS PI16-02151, PI19-01187]
FX This study was supported by grants from Instituto de Salud Carlos III
   (FIS PI16-02151, PI19-01187)
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NR 40
TC 2
Z9 2
U1 1
U2 4
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1660-8151
EI 2235-3186
J9 NEPHRON
JI Nephron
PD SEP
PY 2023
VL 147
IS 9
BP 560
EP 571
DI 10.1159/000531334
EA JUN 2023
PG 12
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA Q6SO4
UT WOS:001010223500001
PM 37276852
DA 2025-06-11
ER

PT J
AU Liu, PF
   Anandhan, A
   Chen, JJ
   Shakya, A
   Dodson, M
   Ooi, A
   Chapman, E
   White, E
   Garcia, JGN
   Zhang, DD
AF Liu, Pengfei
   Anandhan, Annadurai
   Chen, Jinjing
   Shakya, Aryatara
   Dodson, Matthew
   Ooi, Aikseng
   Chapman, Eli
   White, Eileen
   Garcia, Joe G. N.
   Zhang, Donna D.
TI Decreased autophagosome biogenesis, reduced NRF2, and enhanced
   ferroptotic cell death are underlying molecular mechanisms of
   non-alcoholic fatty liver disease
SO REDOX BIOLOGY
LA English
DT Article
DE NRF2; KEAP1; High fat diet; Autophagy; Ferroptosis; Liver steatosis;
   NAFLD; ATG7; mTOR; AKT; AMPK; Fatty acids
ID TRANSCRIPTION FACTOR NRF2; OXIDATIVE STRESS; KEAP1; PROTEIN;
   STEATOHEPATITIS; INACTIVATION; DEGRADATION; ACTIVATION; REGULATOR;
   PATHWAY
AB Background and aims: Caloric excess and sedentary lifestyles have led to an epidemic of obesity, metabolic syndrome, and non-alcoholic fatty liver disease (NAFLD). The objective of this study was to investigate the mechanisms underlying high fat diet (HFD)-induced NAFLD, and to explore NRF2 activation as a strategy to alleviate NAFLD.Approach and results: Herein, we demonstrated that high fat diet (HFD) induced lipid peroxidation and ferrop-tosis, both of which could be alleviated by NRF2 upregulation. Mechanistically, HFD suppressed autophagosome biogenesis through AMPK-and AKT-mediated mTOR activation and decreased ATG7, resulting in KEAP1 sta-bilization and decreased NRF2 levels in mouse liver. Furthermore, ATG7 is required for HFD-induced NRF2 downregulation, as ATG7 deletion in Cre-inducible ATG7 knockout mice decreased NRF2 levels and enhanced ferroptosis, which was not further exacerbated by HFD. This finding was recapitulated in mouse hepatocytes, which showed a similar phenotype upon treatment with saturated fatty acids (SFAs) but not monounsaturated fatty acids (MUFAs). Finally, NRF2 activation blocked fatty acid (FA)-mediated NRF2 downregulation, lipid peroxidation, and ferroptosis. Importantly, the HFD-induced alterations were also observed in human fatty liver tissue samples. Conclusions: HFD-mediated autophagy inhibition, NRF2 suppression, and ferroptosis promotion are important molecular mechanisms of obesity-driven metabolic diseases. NRF2 activation counteracts HFD-mediated NRF2 suppression and ferroptotic cell death. In addition, SFA vs. MUFA regulation of NRF2 may underlie their harmful vs. beneficial effects. Our study reveals NRF2 as a key player in the development and progression of fatty liver disease and that NRF2 activation could serve as a potential therapeutic strategy.
C1 [Liu, Pengfei; Anandhan, Annadurai; Chen, Jinjing; Shakya, Aryatara; Dodson, Matthew; Ooi, Aikseng; Chapman, Eli; Zhang, Donna D.] Univ Arizona, Coll Pharm, Dept Pharmacol & Toxicol, Tucson, AZ 85721 USA.
   [Liu, Pengfei] Xi An Jiao Tong Univ, Natl & Local Joint Engn Res Ctr Biodiag & Biothera, Affiliated Hosp 2, Xian, Peoples R China.
   [Liu, Pengfei] Xi An Jiao Tong Univ, Int Joint Res Ctr Cell Stress & Dis Diag & Therapy, Affiliated Hosp 2, Xian, Peoples R China.
   [White, Eileen] Rutgers Canc Inst New Jersey, Dept Mol Biol & Biochem, New Brunswick, NJ USA.
   [Garcia, Joe G. N.] Univ Arizona, Dept Med, Tucson, AZ 85721 USA.
   [Garcia, Joe G. N.] Univ Arizona, Arizona Hlth Sci Ctr, Tucson, AZ 85721 USA.
   [Zhang, Donna D.] Univ Arizona, Univ Arizona Canc Ctr, Tucson, AZ 85721 USA.
   [Zhang, Donna D.] Univ Arizona, Coll Pharm, 1703 E Mabel St, Tucson, AZ 85721 USA.
C3 University of Arizona; Xi'an Jiaotong University; Xi'an Jiaotong
   University; Rutgers University System; Rutgers University New Brunswick;
   Rutgers University Biomedical & Health Sciences; Rutgers Cancer
   Institute of New Jersey; University of Arizona; University of Arizona;
   University of Arizona Health Sciences; University of Arizona; University
   of Arizona
RP Zhang, DD (corresponding author), Univ Arizona, Coll Pharm, 1703 E Mabel St, Tucson, AZ 85721 USA.
EM dzhang@pharmacy.arizona.edu
RI Liu, Pengfei/LTF-3543-2024
OI zhang, donna/0000-0002-8972-697X
FU National Institutes of Health;  [R35ES031575];  [P42ES004940]; 
   [R01ES031463];  [P30 ES006694]
FX Funding Research reported was supported by the following grants from the
   National Institutes of Health: R35ES031575 and P42ES004940 to DDZ, and
   R01ES031463 to EC, Center grant P30 ES006694.
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NR 45
TC 42
Z9 46
U1 2
U2 47
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2213-2317
J9 REDOX BIOL
JI Redox Biol.
PD FEB
PY 2023
VL 59
AR 102570
DI 10.1016/j.redox.2022.102570
EA DEC 2022
PG 14
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 6W4MZ
UT WOS:000895705300002
PM 36495698
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Maekawa, M
   Maekawa, T
   Sasase, T
   Takagi, K
   Takeuchi, S
   Kitamoto, M
   Nakagawa, T
   Toyoda, K
   Konishi, N
   Ohta, T
   Yamada, T
AF Maekawa, Mariko
   Maekawa, Tatsuya
   Sasase, Tomohiko
   Takagi, Kayoko
   Takeuchi, Satomi
   Kitamoto, Mari
   Nakagawa, Tatsuro
   Toyoda, Kaoru
   Konishi, Noriko
   Ohta, Takeshi
   Yamada, Takahisa
TI Pathophysiological Analysis of Uninephrectomized db/db Mice as a Model
   of Severe Diabetic Kidney Disease
SO PHYSIOLOGICAL RESEARCH
LA English
DT Article
DE &nbsp; Diabetic kidney disease; db; db mice; Tubular interstitial
   fibrosis
ID INTERSTITIAL FIBROSIS; METABOLIC SYNDROME; OXIDATIVE STRESS; TYPE-2;
   INFLAMMATION; LOSARTAN
AB Diabetic nephropathy, included in diabetic kidney disease (DKD), is the primary disease leading to end-stage renal disease (ESRD) or dialysis treatment, accounting for more than 40 % of all patients with ESRD or receiving dialysis. Developing new therapeutics to prevent the transition to ESRD or dialysis treatment requires an understanding of the pathophysiology of DKD and an appropriate animal model for drug efficacy studies. In this study, we investigated the pathophysiology of diabetic kidney disease with type 2 diabetes in uninephrectomized db/db mice. In addition, the nephrectomized db/db mice from 10 weeks to 42 weeks were used to assess the efficacy of longterm administration of the angiotensin-II-receptor antagonist losartan. The blood and urinary biochemical parameters and the blood pressure which is a main pharmacological endpoint of the losartan therapy, were periodically measured. And at the end, histopathological analysis was performed. Uninephrectomized db/db mice clearly developed obesity and hyperglycemia from young age. Furthermore, they showed renal pathophysiological changes, such as increased urinary albumin-creatinine ratio (UACR) (the peak value 3104 +/- 986 in 40-week-old mice), glomerular hypertrophy and increased fibrotic areas in the tubulointerstitial tubules. The blood pressure in the losartan group was significantly low compared to the normotensive Vehicle group. However, as expected, Losartan suppressed the increase in UACR (829 +/- 500) indicating the medication was sufficient, but the histopathological abnormalities including tubular interstitial fibrosis did not improve. These results suggest that the uninephrectomized db/db mice are useful as an animal model of the severe DKD indicated by the comparison of the efficacy of losartan in this model with the efficacy of losartan in clinical practice.
C1 [Maekawa, Mariko; Maekawa, Tatsuya; Sasase, Tomohiko; Takagi, Kayoko; Takeuchi, Satomi; Kitamoto, Mari; Nakagawa, Tatsuro; Konishi, Noriko] Japan Tobacco Inc, Cent Pharmaceut Res Inst, Biol Pharmacol Res Labs, Osaka, Japan.
   [Maekawa, Mariko; Yamada, Takahisa] Niigata Univ, Grad Sch Sci & Technol, Niigata, Japan.
   [Toyoda, Kaoru] Japan Tobacco Inc, Cent Pharmaceut Res Inst, Toxicol Res Labs, Kanagawa, Japan.
   [Ohta, Takeshi] Kyoto Univ, Grad Sch Agr, Lab Anim Physiol & Funct Anat, Kyoto, Japan.
C3 Japan Tobacco Inc.; Niigata University; Japan Tobacco Inc.; Kyoto
   University
RP Maekawa, T (corresponding author), Japan Tobacco Inc, Cent Pharmaceut Res Inst, Biol Pharmacol Res Labs, Osaka, Japan.
EM tatsuya.maekawa@jt.com
OI Maekawa, Tatsuya/0000-0001-7871-4503; tai tian, yi/0000-0002-9573-3455
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NR 32
TC 7
Z9 8
U1 0
U2 2
PU ACAD SCIENCES CZECH REPUBLIC, INST PHYSIOLOGY
PI PRAGUE 4
PA VIDENSKA 1083, PRAGUE 4 142 20, CZECH REPUBLIC
SN 0862-8408
EI 1802-9973
J9 PHYSIOL RES
JI Physiol. Res.
PD APR
PY 2022
VL 71
IS 2
BP 209
EP 217
DI 10.33549/physiolres.934784
PG 9
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA 1M9AY
UT WOS:000800258700004
PM 35344670
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Rizzo, MR
   Di Meo, I
   Polito, R
   Auriemma, MC
   Gambardella, A
   di Mauro, G
   Capuano, A
   Paolisso, G
AF Rizzo, Maria Rosaria
   Di Meo, Irene
   Polito, Rita
   Auriemma, Maria Chiara
   Gambardella, Antonio
   di Mauro, Gabriella
   Capuano, Annalisa
   Paolisso, Giuseppe
TI Cognitive impairment and type 2 diabetes mellitus: Focus of SGLT2
   inhibitors treatment
SO PHARMACOLOGICAL RESEARCH
LA English
DT Review
DE Gliflozins; Sodium-glucose co-transporter (SGLT); SGLT2 inhibitors; Type
   2 diabetes mellitus (T2DM); Cognitive impairment; Central Nervous System
   (CNS)
ID GLUCOSE COTRANSPORTER-2 INHIBITORS; GLUCAGON-LIKE PEPTIDE-1;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; BRAIN; DAPAGLIFLOZIN;
   PERFORMANCE; DYSFUNCTION; MECHANISMS; DISEASE
AB Gliflozins are a novel class of oral anti-diabetic drugs, acting as inhibitors of sodium-glucose co-transporters (SGLTs) through the proximal convoluted tubules (PCT) and intestinal epithelium. The sodium-glucose cotransporters 2 (SGLT2) are mainly expressed in S1 and S2 segments of the proximal convoluted tubule in the kidneys. Clinical guidelines recommend their use especially in Type 2 Diabetes mellitus (T2DM) patients with vascular complications and/or heart failure highlighting the importance of sodium-glucose co-transporter 2 inhibitors (SGLT2i) pleiotropic effects. Interestingly, cognitive decline is a widely recognized complication of T2DM and, in addition, to clarify its pathophysiology, there is an urgent need to understand how and if diabetes therapies can control diabetes-related cognitive dysfunction. At the time, although SGLT2 proteins are present in the Central Nervous System (CNS), the SGLT2i effects on cognitive impairments remain partly unknown. In preclinical studies, SGLT2i ameliorates cognitive dysfunction in obese and T2DM mice, reducing oxidative stress, neuroinflammation and improving neuronal plasticity and mitochondrial brain pathway. In addition, SGLT2i could bring back mTOR to a physiological state of activation, stopping neurodegenerative diseases' onset or progression. Instead, clinical studies on T2DM-related cognitive dysfunction treated by SGLT2i are much more limited. For these reasons, further studies are needed to better elucidate if SGLT2i therapy can affect T2DMrelated cognitive decline. In this scenario, this review aims to summarize the state of knowledge on the role of SGLT2i in T2DM-related cognitive dysfunction and stimulate new clinical trials.
C1 [Rizzo, Maria Rosaria; Di Meo, Irene; Polito, Rita; Auriemma, Maria Chiara; Paolisso, Giuseppe] Univ Campania Luigi Vanvitelli, Dept Adv Med & Surg Sci, I-80138 Naples, Italy.
   [Gambardella, Antonio] Univ Campania Luigi Vanvitelli, Dept Precis Med, I-80138 Naples, Italy.
   [di Mauro, Gabriella; Capuano, Annalisa] Univ Campania Luigi Vanvitelli, Dept Expt Med, Sect Pharmacol L Donatelli, I-80138 Naples, Italy.
C3 Universita della Campania Vanvitelli; Universita della Campania
   Vanvitelli; Universita della Campania Vanvitelli
RP Rizzo, MR (corresponding author), Univ Campania Luigi Vanvitelli, Dept Adv Med & Surg Sci, I-80138 Naples, Italy.
EM mariarosaria.rizzo@unicampania.it
RI Gambardella, Antonio/F-5295-2012; Rizzo, Maria/HGD-6576-2022; Di Meo,
   Irene/HDN-2514-2022; Capuano, Annalisa/HTL-3144-2023
OI di Mauro, Gabriella/0000-0001-5096-7277; Di Meo,
   Irene/0000-0002-4616-1454; auriemma, maria chiara/0009-0001-2847-2363
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NR 92
TC 95
Z9 103
U1 14
U2 63
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 1043-6618
EI 1096-1186
J9 PHARMACOL RES
JI Pharmacol. Res.
PD FEB
PY 2022
VL 176
AR 106062
DI 10.1016/j.phrs.2022.106062
EA JAN 2022
PG 7
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 1C5DV
UT WOS:000793140600010
PM 35017046
OA hybrid
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Gouveia, SSV
   Gouveia, GPD
   Souza, LM
   da Costa, BC
   Sousa, GHM
   Pinho, VA
   Vasconcelos, SS
   Souza, ATD
   Lopes, TD
   Pinheiro, LGP
AF Vasconcelos Gouveia, Samara Sousa
   de Morais Gouveia, Guilherme Pertinni
   Souza, Leydnaya Maria
   da Costa, Bruno Cunha
   Melo Sousa, Gustavo Henrique
   Pinho, Vanadia Almeida
   Vasconcelos, Samila Sousa
   Dos Santos Souza, Antonia Tainara
   Lopes, Thamires da Silva
   Porto Pinheiro, Luiz Gonzaga
TI Heart Rate Variability and Respiratory Muscle Strength in Patients With
   Type II Diabetes Practicing Pilates: A Randomized Clinical Trial
SO CURRENT DIABETES REVIEWS
LA English
DT Article
DE Diabetes mellitus; exercise movement techniques; biomarkers; oxidative
   stress; heart rate variability; respiratory muscle strength
ID METABOLIC SYNDROME; REFERENCE VALUES; EXERCISE; PRESSURES; RISK
AB Purpose: This study aimed to analyze the effect of a Pilates protocol on respiratory muscle strength and heart rate variability (HRV) in patients with type 2 diabetes.
   Method: A randomized clinical trial (RBR-2gc2qj) was conducted on a type 2 diabetic target population. Patients practiced the Pilates protocol for 8 weeks, with two visits per week. The variables tested were maximum inspiratory pressure (MIP), maximum expiratory pressure (MEP), and HRV (time and frequency domains). All variables were tested for normal distribution. Using SPSS 21.0, analysis of variance was performed for variables with normal distribution, and the Wilcoxon and Friedman tests were used for variables that did not show a normal distribution, with a 5% significance level.
   Results: Forty-four participants were included in the study (intervention group: 22; control group: 22; mean age: 61.23 +/- 8.49 years), most of whom were female (77.3%), married or in a consensual union (59.1%), had complete literacy (31.8%), and had an average body mass index of 26.96 +/- 4.35 kg/m(2). There were no significant differences in MIP and MEP b efore and after the protocol between the intervention and control groups. Regarding HRV, there were significant differences in autonomic modulation, especially between the moments before and during exercise and between the moments during and after exercise; however, it was not possible to determine which system (sympathetic or parasympathetic) is most involved in these changes.
   Conclusion: The exercise protocol based on the Pilates method did not alter respiratory muscle strength but promoted changes in HRV, especially between the moments before and during exercise and during and after exercise.
C1 [Vasconcelos Gouveia, Samara Sousa; de Morais Gouveia, Guilherme Pertinni; da Costa, Bruno Cunha; Pinho, Vanadia Almeida; Dos Santos Souza, Antonia Tainara; Lopes, Thamires da Silva] Fed Univ Delta Parnaiba, Dept Physiotherapy, Piaui, Brazil.
   [Vasconcelos Gouveia, Samara Sousa; de Morais Gouveia, Guilherme Pertinni; Melo Sousa, Gustavo Henrique; Dos Santos Souza, Antonia Tainara; Lopes, Thamires da Silva] Res Grp Evaluat & Therapeut Physiotherapy GPFAT, Sobral, Ceara, Brazil.
   [de Morais Gouveia, Guilherme Pertinni; Souza, Leydnaya Maria] Postgrad Program Biomed Sci, Sobral, Ceara, Brazil.
   [Vasconcelos, Samila Sousa] UNINTA Univ Ctr, Sobral, Ceara, Brazil.
   [Porto Pinheiro, Luiz Gonzaga] Univ Fed Ceara, Dept Med Surg Sci, Fortaleza, Ceara, Brazil.
C3 Universidade Federal do Ceara
RP Gouveia, GPD (corresponding author), Fed Univ Delta Parnaiba, Dept Physiotherapy, Piaui, Brazil.
EM gpfatufpi@gmail.com
RI de Morais Gouveia, Guilherme/AAP-6239-2021
OI Souza, Leydnaya Maria/0000-0002-5210-7331; GOUVEIA, GUILHERME PERTINNI
   DE MORAIS/0000-0001-6470-2341; Lopes, Thamires/0000-0001-8705-4025;
   Cunha, Bruno/0000-0002-6122-5487; Melo, Gustavo/0000-0002-7039-7520; Dos
   Santos Souza, Antonia Tainara/0000-0002-8826-4291; Sousa Vasconcelos
   Gouveia, Samara/0000-0003-1826-4592
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NR 32
TC 1
Z9 2
U1 2
U2 7
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1573-3998
EI 1875-6417
J9 CURR DIABETES REV
JI Curr. Diabetes Reviews
PY 2022
VL 18
IS 6
AR e280921196866
DI 10.2174/1573399817666210928143752
PG 8
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA 2U7BW
UT WOS:000823312600011
PM 34602038
DA 2025-06-11
ER

PT J
AU Silver, Z
   Abbott-Tate, S
   Hyland, L
   Sherratt, F
   Woodside, B
   Abizaid, A
AF Silver, Zachary
   Abbott-Tate, Sam
   Hyland, Lindsay
   Sherratt, Frances
   Woodside, Barbara
   Abizaid, Alfonso
TI Ghrelin receptor signaling is not required for glucocorticoid-induced
   obesity in female mice
SO JOURNAL OF ENDOCRINOLOGY
LA English
DT Article
DE ghrelin; GHSR; corticosterone; obesity; glucose tolerance; metabolism
ID DEPRESSIVE-LIKE BEHAVIOR; METABOLIC SYNDROME; CHRONIC CORTICOSTERONE;
   NEUROPEPTIDE-Y; GLUCOSE-HOMEOSTASIS; INSULIN-RESISTANCE; ARCUATE
   NUCLEUS; GENE-EXPRESSION; CHRONIC STRESS; ESTROUS-CYCLE
AB Chronic exposure to high circulating glucocorticoid or ghrelin concentrations increases food intake, weight gain and adiposity, suggesting that ghrelin could contribute to the metabolic effects of chronic glucocorticoids. In male mice, however, blocking ghrelin receptor ( GHSR) signaling increased the weight gain and adiposity induced by chronic corticosterone (CORT), rather than attenuating them. In the current study, we investigated the role of GHSR signaling in the metabolic effects of chronic exposure to high circulating CORT in female mice. To do this, female WT and GHSR KO mice were treated with either CORT in a 1% ethanol (EtOH) solution or 1% EtOH alone in their drinking water for 32 days (n = 5-8/group). Body weight, food, and water intake as well as vaginal cyclicity were assessed daily. As expected, CORT treatment-induced significant increases in body weight, food intake, adiposity and also impaired glucose tolerance. In contrast to results observed in male mice, WT and GHSR KO female mice did not differ on any of these parameters. Neither plasma levels of ghrelin, LEAP-2, the endogenous GHSR antagonist produced by the liver, nor their ratio were altered by chronic glucocorticoid exposure. In addition, CORT treatment disrupted vaginal cyclicity, produced a reduction in sucrose consumption and increased locomotor activity regardless of genotype. Chronic CORT also decreased exploration in WT but not GHSR KO mice. Collectively, these data suggest that most metabolic, endocrine, reproductive and behavioral effects of chronic CORT exposure are independent of GHSR signaling in female mice.
C1 [Silver, Zachary; Abbott-Tate, Sam; Hyland, Lindsay; Sherratt, Frances; Woodside, Barbara; Abizaid, Alfonso] Carleton Univ, Dept Neurosci, Ottawa, ON, Canada.
C3 Carleton University
RP Abizaid, A (corresponding author), Carleton Univ, Dept Neurosci, Ottawa, ON, Canada.
EM alfonso_abizaid@carleton.ca
OI Sherratt, Frances/0009-0006-8299-971X; Silver,
   Zachary/0000-0002-3064-6182
FU Canadian Institutes for Health Research (CIHR); NSERC USRA scholarship;
   Carleton University DSRI scholarship; Carleton University I-CUREUS award
FX The current work was supported by funding from the Canadian Institutes
   for Health Research (CIHR) awarded to AA, an NSERC USRA scholarship, a
   Carleton University DSRI scholarship and a Carleton University I-CUREUS
   award to ZS and a Carleton University I-CUREUS award to FS.
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NR 76
TC 6
Z9 6
U1 0
U2 6
PU BIOSCIENTIFICA LTD
PI BRISTOL
PA STARLING HOUSE, 1600 BRISTOL PARKWAY N, BRISTOL, ENGLAND
SN 0022-0795
EI 1479-6805
J9 J ENDOCRINOL
JI J. Endocrinol.
PD AUG
PY 2021
VL 250
IS 2
BP 37
EP 48
DI 10.1530/JOE-20-0579
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA UN1CZ
UT WOS:000693760600002
PM 34060474
OA Bronze
DA 2025-06-11
ER

PT J
AU Haziza, C
   de la Bourdonnaye, G
   Donelli, A
   Skiada, D
   Poux, V
   Weitkunat, R
   Baker, G
   Picavet, P
   Lüdicke, F
AF Haziza, Christelle
   de la Bourdonnaye, Guillaume
   Donelli, Andrea
   Skiada, Dimitra
   Poux, Valerie
   Weitkunat, Rolf
   Baker, Gizelle
   Picavet, Patrick
   Ludicke, Frank
TI Favorable Changes in Biomarkers of Potential Harm to Reduce the Adverse
   Health Effects of Smoking in Smokers Switching to the Menthol Tobacco
   Heating System 2.2 for 3 Months (Part 2)
SO NICOTINE & TOBACCO RESEARCH
LA English
DT Article
ID CLINICAL-EXPOSURE EVALUATION; CONTINUED CIGARETTE-SMOKING; HEATED
   CIGARETTE; SEQUENTIAL CONFINEMENT; CARDIOVASCULAR-DISEASE; BIOLOGICAL
   IMPACT; OPEN-LABEL; RISK; PRODUCT; AEROSOL
AB Introduction: Tobacco Heating System (THS) 2.2, a candidate modified-risk tobacco product, aims at offering an alternative to cigarettes for smokers while substantially reducing the exposure to harmful and potentially harmful constituents found in cigarette smoke.
   Methods: One hundred and sixty healthy adult US smokers participated in this randomized, three-arm parallel group, controlled clinical study. Subjects were randomized in a 2:1:1 ratio to menthol Tobacco Heating System 2.2 (mTHS), menthol cigarette, or smoking abstinence for 5 days in confinement and 86 subsequent ambulatory days. Endpoints included biomarkers of exposure to harmful and potentially harmful constituents (reported in our co-publication, Part 1) and biomarkers of potential harm (BOPH).
   Results: Compliance (protocol and allocated product exposure) was 51% and 18% in the mTHS and smoking abstinence arms, respectively, on day 90. Nonetheless, favorable changes in BOPHs of lipid metabolism (total cholesterol and high- and low-density cholesterol), endothelial dysfunction (soluble intercellular adhesion molecule-1), oxidative stress (8-epi-prostaglandin F-2 alpha), and cardiovascular risk factors (eg, high-sensitivity C-reactive protein) were observed in the mTHS group. Favorable effects in other BOPHs, including ones related to platelet activation (11-dehydrothromboxane B2) and metabolic syndrome (glucose), were more pronounced in normal weight subjects.
   Conclusions: The results suggest that the reduced exposure demonstrated when switching to mTHS is associated with overall improvements in BOPHs, which are indicative of pathomechanistic pathways underlying the development of smoking-related diseases, with some stronger effects in normal weight subjects.
C1 [Haziza, Christelle; de la Bourdonnaye, Guillaume; Donelli, Andrea; Skiada, Dimitra; Poux, Valerie; Weitkunat, Rolf; Baker, Gizelle; Picavet, Patrick; Ludicke, Frank] Philip Morris Prod SA, PMI Res & Dev, Quai Jeanrenaud 5, CH-2000 Neuchatel, Switzerland.
C3 Philip Morris International Inc
RP Haziza, C (corresponding author), Philip Morris Prod SA, PMI Res & Dev, Quai Jeanrenaud 5, CH-2000 Neuchatel, Switzerland.
EM christelle.haziza@pmi.com
RI Weitkunat, Rolf/IAM-8318-2023
OI de La Bourdonnaye, Guillaume/0000-0002-3412-0188
FU Philip Morris International
FX Philip Morris International is the sole source of funding and sponsor of
   this project.
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NR 48
TC 35
Z9 38
U1 0
U2 7
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1462-2203
EI 1469-994X
J9 NICOTINE TOB RES
JI Nicotine Tob. Res.
PD APR
PY 2020
VL 22
IS 4
BP 549
EP 559
DI 10.1093/ntr/ntz084
PG 11
WC Substance Abuse; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Substance Abuse; Public, Environmental & Occupational Health
GA MH8JC
UT WOS:000546967300014
PM 31125079
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Clark, JL
   Taylor, CG
   Zahradka, P
AF Clark, Jaime L.
   Taylor, Carla G.
   Zahradka, Peter
TI Rebelling against the (Insulin) Resistance: A Review of the Proposed
   Insulin-Sensitizing Actions of Soybeans, Chickpeas, and Their Bioactive
   Compounds
SO NUTRIENTS
LA English
DT Review
DE soybeans; pulses; chickpeas; insulin resistance; bioactive compounds;
   GLUT4; PPAR gamma; adipokines; adiponectin; short-chain fatty acids
ID HIGH-FAT-DIET; INHIBIT ADIPOCYTE DIFFERENTIATION; ANTIOXIDANT
   ENZYME-ACTIVITIES; GLYCINE-MAX L.; PPAR-GAMMA; SOY ISOFLAVONES;
   OXIDATIVE STRESS; LIPID-METABOLISM; 3T3-L1 PREADIPOCYTES;
   MOLECULAR-MECHANISMS
AB Insulin resistance is a major risk factor for diseases such as type 2 diabetes and metabolic syndrome. Current methods for management of insulin resistance include pharmacological therapies and lifestyle modifications. Several clinical studies have shown that leguminous plants such as soybeans and pulses (dried beans, dried peas, chickpeas, lentils) are able to reduce insulin resistance and related type 2 diabetes parameters. However, to date, no one has summarized the evidence supporting a mechanism of action for soybeans and pulses that explains their ability to lower insulin resistance. While it is commonly assumed that the biological activities of soybeans and pulses are due to their antioxidant activities, these bioactive compounds may operate independent of their antioxidant properties and, thus, their ability to potentially improve insulin sensitivity via alternative mechanisms needs to be acknowledged. Based on published studies using in vivo and in vitro models representing insulin resistant states, the proposed mechanisms of action for insulin-sensitizing actions of soybeans, chickpeas, and their bioactive compounds include increasing glucose transporter-4 levels, inhibiting adipogenesis by down-regulating peroxisome proliferator-activated receptor-gamma, reducing adiposity, positively affecting adipokines, and increasing short-chain fatty acid-producing bacteria in the gut. Therefore, this review will discuss the current evidence surrounding the proposed mechanisms of action for soybeans and certain pulses, and their bioactive compounds, to effectively reduce insulin resistance.
C1 [Clark, Jaime L.; Taylor, Carla G.; Zahradka, Peter] St Boniface Gen Hosp, Albrechtsen Res Ctr, Canadian Ctr Agrifood Res Hlth & Med, Winnipeg, MB R2H 2A6, Canada.
   [Clark, Jaime L.; Taylor, Carla G.; Zahradka, Peter] Univ Manitoba, Dept Food & Human Nutr Sci, Winnipeg, MB R3T 2N2, Canada.
   [Taylor, Carla G.; Zahradka, Peter] Univ Manitoba, Dept Physiol & Pathophysiol, Winnipeg, MB R3E 0T5, Canada.
C3 University of Manitoba; Children's Hospital Research Institute of
   Manitoba; Saint Boniface Hospital; University of Manitoba; University of
   Manitoba
RP Zahradka, P (corresponding author), St Boniface Gen Hosp, Albrechtsen Res Ctr, Canadian Ctr Agrifood Res Hlth & Med, Winnipeg, MB R2H 2A6, Canada.; Zahradka, P (corresponding author), Univ Manitoba, Dept Food & Human Nutr Sci, Winnipeg, MB R3T 2N2, Canada.; Zahradka, P (corresponding author), Univ Manitoba, Dept Physiol & Pathophysiol, Winnipeg, MB R3E 0T5, Canada.
EM jclark@sbrc.ca; ctaylor@sbrc.ca; pzahradka@sbrc.ca
RI Zahradka, Peter/KDM-4700-2024
OI Zahradka, Peter/0000-0002-7814-0658; Clark, Jaime/0000-0001-8322-5149;
   Taylor, Carla G./0000-0003-3358-6418
FU Manitoba Pulse and Soybean Growers
FX The authors' (C.G.T. and P.Z.) research program has been supported by
   funding from the Manitoba Pulse and Soybean Growers. J.L.C. holds a
   studentship from the Canadian Institutes of Health Research. No external
   funding was received for this work.
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NR 109
TC 30
Z9 31
U1 1
U2 31
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD APR
PY 2018
VL 10
IS 4
AR 434
DI 10.3390/nu10040434
PG 28
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA GJ3HN
UT WOS:000435182900050
PM 29601521
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Cho, DY
   Yeo, JK
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   Jung, JE
   Yang, SJ
   Kong, DH
   Ha, JK
   Kim, JG
   Park, MG
AF Cho, Dae-Yeon
   Yeo, Jeong Kyun
   Cho, Seung Ik
   Jung, Jae Eun
   Yang, Sang Jin
   Kong, Doo Hwan
   Ha, Jeong Ku
   Kim, Jin Goo
   Park, Min Gu
TI Exercise improves the effects of testosterone replacement therapy and
   the durability of response after cessation of treatment: a pilot
   randomized controlled trial
SO ASIAN JOURNAL OF ANDROLOGY
LA English
DT Article
DE erectile dysfunction; exercise; hypogonadism; testosterone
ID HEAVY RESISTANCE; OXIDATIVE STRESS; ERECTILE DYSFUNCTION; SERUM
   TESTOSTERONE; HORMONAL RESPONSES; METABOLIC SYNDROME; BODY-COMPOSITION;
   HYPOGONADAL MEN; PROSTATE-CANCER; BLOOD-PRESSURE
AB The effects of the combination of exercise and TRT on symptoms of late-onset hypogonadism (LOH) and the durability of response after cessation of TRT were investigated. A total of fifty patients with erectile dysfunction (ED) who had a sedentary lifestyle and low serum total testosterone (T) levels were enrolled and followed for 20 weeks. Patients were randomly divided into two groups; all of them received T gel for 12 weeks and it was discontinued for 8 weeks. Patients assigned to Group II were offered a supervised exercise program for 20 weeks. Measurement of serological testing was performed and self-assessment questionnaires and Global Assessment Question (GAQ) were asked. Baseline characteristics and the initial symptom scores showed no significant difference between the two groups. Serum total T levels and the symptom scores were increased at 12 weeks in both groups, and Group II showed better results with statistical significance. There was a decrease in T levels and worsening of symptom scores at week 20 compared to week 12 in both groups, and Group II showed better results with statistical significance. On the GAQ, Group II showed higher ratio of "yes" at week 12 and the same tendency was sustained at week 20 with significant difference between two groups. The combination of exercise and TRT showed significant improvements in serum T levels and LOH symptoms compared to TRT alone. In addition, these improvements were maintained in the combination group with continuous exercise, even after cessation of TRT.
C1 [Cho, Dae-Yeon] Inje Univ, Sanggye Paik Hosp, Dept Urol, Seoul, South Korea.
   [Yeo, Jeong Kyun; Park, Min Gu] Inje Univ, Seoul Paik Hosp, Dept Urol, Seoul, South Korea.
   [Cho, Seung Ik; Yang, Sang Jin; Kim, Jin Goo] KonKuk Univ, Med Ctr, Dept Orthoped, Seoul, South Korea.
   [Jung, Jae Eun; Kong, Doo Hwan; Ha, Jeong Ku] Inje Univ, Seoul Paik Hosp, Dept Orthoped, Ctr Sports Med, Seoul, South Korea.
C3 Inje University; Inje University; Konkuk University; Konkuk University
   Medical Center; Inje University
RP Park, MG (corresponding author), Inje Univ, Seoul Paik Hosp, Dept Urol, Seoul, South Korea.
EM uromgpark@gmail.com
RI Park, Min Gu/E-4486-2015
OI Yeo, Jeongkyun/0000-0001-5027-3451; gong, duhwan/0000-0002-8140-9937
CR Aizawa K, 2011, MED SCI SPORT EXER, V43, P2072, DOI 10.1249/MSS.0b013e31821e9d74
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NR 36
TC 14
Z9 15
U1 0
U2 6
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, 400059, INDIA
SN 1008-682X
EI 1745-7262
J9 ASIAN J ANDROL
JI Asian J. Androl.
PD SEP-OCT
PY 2017
VL 19
IS 5
BP 602
EP 607
DI 10.4103/1008-682X.184269
PG 6
WC Andrology; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Urology & Nephrology
GA FE0JP
UT WOS:000407906900018
PM 27427553
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Zou, TD
   Chen, DW
   Yang, QY
   Wang, B
   Zhu, MJ
   Nathanielsz, PW
   Du, M
AF Zou, Tiande
   Chen, Daiwen
   Yang, Qiyuan
   Wang, Bo
   Zhu, Mei-Jun
   Nathanielsz, Peter W.
   Du, Min
TI Resveratrol supplementation of high-fat diet-fed pregnant mice promotes
   brown and beige adipocyte development and prevents obesity in male
   offspring
SO JOURNAL OF PHYSIOLOGY-LONDON
LA English
DT Article
ID WHITE ADIPOSE-TISSUE; UP-REGULATE AMPK; MATERNAL OBESITY; OXIDATIVE
   STRESS; GENE-EXPRESSION; EARLY-LIFE; MITOCHONDRIAL-FUNCTION; METABOLIC
   DISEASE; BODY-WEIGHT; ADULT MICE
AB Promoting beige/brite adipogenesis and thermogenic activity is considered as a promising therapeutic approach to reduce obesity and metabolic syndrome. Maternal obesity impairs offspring brown adipocyte function and correlates with obesity in offspring. We previously found that dietary resveratrol (RES) induces beige adipocyte formation in adult mice. Here, we evaluated further the effect of resveratrol supplementation of pregnant mice on offspring thermogenesis and energy expenditure. Female C57BL/6 J mice were fed a control diet (CON) or a high-fat diet (HFD) with or without 0.2% (w/w) RES during pregnancy and lactation. Male offspring were weaned onto a HFD and maintained on this diet for 11 weeks. The offspring thermogenesis and related regulatory factors in adipose tissue were evaluated. At weaning, HFD offspring had lower thermogenesis in brown and white adipose tissues compared with CON offspring, which was recovered by maternal RES supplementation, along with the appearance of multilocular brown/beige adipocytes and elevated thermogenic gene expression. Adult offspring of RES-treated mothers showed increased energy expenditure and insulin sensitivity when on an obesogenic diet comparedwithHFDoffspring. The elevated metabolic activity was correlated with enhanced brown adipose function and white adipose tissue browning in HFD+RES compared with HFD offspring. In conclusion, RES supplementation of HFD-fed dams during pregnancy and lactation promoted white adipose browning and thermogenesis in offspring at weaning accompanied by persistent beneficial effects in protecting against HFD-induced obesity and metabolic disorders.
C1 [Zou, Tiande; Chen, Daiwen] Sichuan Agr Univ, Inst Anim Nutr, Chengdu 611130, Sichuan, Peoples R China.
   [Zou, Tiande; Yang, Qiyuan; Wang, Bo; Du, Min] Washington State Univ, Washington Ctr Muscle Biol, Pullman, WA 99164 USA.
   [Zou, Tiande; Yang, Qiyuan; Wang, Bo; Du, Min] Washington State Univ, Dept Anim Sci, Pullman, WA 99164 USA.
   [Zhu, Mei-Jun] Washington State Univ, Sch Food Sci, Pullman, WA 99164 USA.
   [Nathanielsz, Peter W.] Univ Wyoming, Dept Anim Sci, Wyoming Pregnancy & Life Course Hlth Ctr, Laramie, WY 82071 USA.
   [Du, Min] China Agr Univ, Beijing Adv Innovat Ctr Food Nutr & Human Hlth, Coll Food Sci & Nutr Engn, Beijing 100194, Peoples R China.
C3 Sichuan Agricultural University; Washington State University; Washington
   State University; Washington State University; University of Wyoming;
   China Agricultural University
RP Du, M (corresponding author), Washington State Univ, Dept Anim Sci, Washington Ctr Muscle Biol, Pullman, WA 99164 USA.
EM min.du@wsu.edu
RI Du, Min/H-4311-2011; zou, tiande/AAE-6768-2019
OI Wang, Bo/0000-0003-0604-1607; Nathanielsz, Peter/0000-0001-8410-6280;
   Du, Min/0000-0002-7232-072X
FU National Institutes of Health [R01-HD067449, R21-AG049976]; National
   Processed Raspberry Council; National Basic Research Program of China
   [2012CB124701]; China Scholarship Council
FX This work was supported by grants from the National Institutes of Health
   (R01-HD067449 and R21-AG049976) and a grant from the National Processed
   Raspberry Council to M.D., the National Basic Research Program of China
   (2012CB124701) to D.C. and a scholarship from the China Scholarship
   Council to T.Z.
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NR 61
TC 126
Z9 132
U1 0
U2 60
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-3751
EI 1469-7793
J9 J PHYSIOL-LONDON
JI J. Physiol.-London
PD MAR 1
PY 2017
VL 595
IS 5
BP 1547
EP 1562
DI 10.1113/JP273478
PG 16
WC Neurosciences; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Physiology
GA EQ5HB
UT WOS:000398112300020
PM 27891610
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Medeiros, RF
   Gaique, TG
   Bento-Bernardes, T
   Motta, NAV
   Brito, FCF
   Fernandes-Santos, C
   Castro-Pinheiro, C
   Oliveira, KJ
   Nóbrega, ACL
AF Medeiros, Renata F.
   Gaique, Thaiane G.
   Bento-Bernardes, Thais
   Motta, Nadia A. V.
   Brito, Fernanda C. F.
   Fernandes-Santos, Caroline
   Castro-Pinheiro, Camila
   Oliveira, Karen J.
   Nobrega, Antonio C. L.
TI Aerobic training prevents oxidative profile and improves nitric oxide
   and vascular reactivity in rats with cardiometabolic alteration
SO JOURNAL OF APPLIED PHYSIOLOGY
LA English
DT Article
DE fructose; endothelium; cardiovascular disease; training; antioxidant
   enzymes
ID INSULIN-RESISTANCE; CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME;
   POSTEXERCISE HYPOTENSION; SKELETAL-MUSCLE; ENDOTHELIAL DYSFUNCTION;
   RISK-FACTORS; FRUCTOSE; STRESS; DIET
AB Cardiovascular disease is the major cause of death worldwide; therefore it is important to understand the natural history of the pathophysiologic process and develop strategies to halt its progression. Thus this study investigated the protective effect of aerobic training on pathophysiological mechanisms involved in subclinical cardiometabolic alterations in a model with constant exposure to a prejudicial agent. Male Wistar rats were divided into a control group (C), which received drinking water, fructose group (F), which was fed 10% fructose in drinking water for 10 wk, and control training (CT) and fructose training groups (FT), in which moderate aerobic training was added in the last 8 wk of the study. Insulin, triacylglycerol, and isoprostane were higher and superoxide dismutase (SOD) was lower in the F group. There was no difference in thoracic aorta histology, but a decreased vascularization was seen in the F group, avoided by training in left ventricle. Regarding vascular function, the F group exhibited increased vasoconstrictory reactivity to phenylephrine. The F group presented impaired vasodilation to acetylcholine. Regarding endothelial nitric oxide synthase (eNOS), the F group presented a lower expression, and phosphorylated eNOS was higher in the trained groups than in their respective control groups. This same pattern was observed for nitric oxide bioavailability, antioxidant protein expression in aorta, left ventricle, and muscle (catalase, SOD, and glutathione peroxidase), serum SOD activity, and muscle mass. These results suggest that exercise training enhanced the antioxidant pathway and, as a consequence, the eNOS pathway, preventing an impairment in vascular vasodilatory capacity.
C1 [Medeiros, Renata F.; Gaique, Thaiane G.; Bento-Bernardes, Thais; Motta, Nadia A. V.; Brito, Fernanda C. F.; Oliveira, Karen J.; Nobrega, Antonio C. L.] Univ Fed Fluminense, Dept Physiol & Pharmacol, Niteroi, RJ, Brazil.
   [Fernandes-Santos, Caroline; Castro-Pinheiro, Camila] Univ Fed Fluminense, Dept Basic Sci, Nova Friburgo, Brazil.
C3 Universidade Federal Fluminense; Universidade Federal Fluminense
RP Nóbrega, ACL (corresponding author), Univ Fed Fluminense, Rua Prof Hernani Pires de Melo 101-106, BR-24210130 Niteroi, RJ, Brazil.
EM anobrega@id.uff.br
RI Oliveira, Karen/AAV-6843-2020; da Nobrega, Antonio/O-5107-2019;
   Medeiros, Renata/AAP-3429-2021; brito, fernanda/AAL-8474-2021;
   Bento-Bernardes, Thais/AAZ-4284-2021; Fernandes-Santos,
   Caroline/M-1794-2019
OI Castro-Pinheiro, Camila/0000-0001-8282-529X; Fernandes-Santos,
   Caroline/0000-0002-2420-3836; Oliveira, Karen/0000-0003-2320-8683
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NR 64
TC 10
Z9 10
U1 0
U2 3
PU AMER PHYSIOLOGICAL SOC
PI Rockville
PA 6120 Executive Blvd, Suite 600, Rockville, MD, UNITED STATES
SN 8750-7587
EI 1522-1601
J9 J APPL PHYSIOL
JI J. Appl. Physiol.
PD JUL 1
PY 2016
VL 121
IS 1
BP 289
EP 298
DI 10.1152/japplphysiol.00369.2015
PG 10
WC Physiology; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology; Sport Sciences
GA DS4KT
UT WOS:000380750700033
PM 27255525
DA 2025-06-11
ER

PT J
AU Verhulst, S
   Dalgård, C
   Labat, C
   Kark, JD
   Kimura, M
   Christensen, K
   Toupance, S
   Aviv, A
   Kyvik, KO
   Benetos, A
AF Verhulst, Simon
   Dalgard, Christine
   Labat, Carlos
   Kark, Jeremy D.
   Kimura, Masayuki
   Christensen, Kaare
   Toupance, Simon
   Aviv, Abraham
   Kyvik, Kirsten O.
   Benetos, Athanase
TI A short leucocyte telomere length is associated with development of
   insulin resistance
SO DIABETOLOGIA
LA English
DT Article
DE Genetics/epidemiology (all); Human; Insulin sensitivity and resistance
ID STRONG HEART FAMILY; OXIDATIVE STRESS; METABOLIC SYNDROME;
   AMERICAN-INDIANS; OBESITY; INFLAMMATION; GLYCEMIA; GLUCOSE; BIOLOGY;
   ADULTS
AB Aims/hypothesis A number of studies have shown that leucocyte telomere length (LTL) is inversely associated with insulin resistance and type 2 diabetes mellitus. The aim of the present longitudinal cohort study, utilising a twin design, was to assess whether shorter LTL predicts insulin resistance or is a consequence thereof.
   Methods Participants were recruited between 1997 and 2000 through the population-based national Danish Twin Registry to participate in the GEMINAKAR study, a longitudinal evaluation of metabolic disorders and cardiovascular risk factors. Baseline and follow-up measurements of LTL and insulin resistance over an average of 12 years were performed in a subset of the Registry consisting of 338 (184 monozygotic and 154 dizygotic) same-sex twin pairs.
   Results Age at baseline examination was 37.4 +/- 9.6 (mean +/- SD) years. Baseline insulin resistance was not associated with age-dependent changes in LTL (attrition) over the follow-up period, whereas baseline LTL was associated with changes in insulin resistance during this period. The shorter the LTL at baseline, the more pronounced was the increase in insulin resistance over the follow-up period (p < 0.001); this effect was additive to that of BMI. The co-twin with the shorter baseline LTL displayed higher insulin resistance at follow-up than the co-twin with the longer LTL.
   Conclusions/interpretation These findings suggest that individuals with short LTL are more likely to develop insulin resistance later in life. By contrast, presence of insulin resistance does not accelerate LTL attrition.
C1 [Verhulst, Simon] Univ Groningen, Groningen Inst Evolutionary Life Sci, Groningen, Netherlands.
   [Dalgard, Christine] Univ Southern Denmark, Dept Publ Hlth, Environm Med, Odense, Denmark.
   [Labat, Carlos; Toupance, Simon; Benetos, Athanase] INSERM, U1116, Vandoeuvre Les Nancy, France.
   [Labat, Carlos; Toupance, Simon; Benetos, Athanase] Univ Lorraine, Nancy, France.
   [Kark, Jeremy D.] Hebrew Univ Jerusalem, Hadassah Sch Publ Hlth & Community Med, Jerusalem, Israel.
   [Kimura, Masayuki; Aviv, Abraham] Rutgers State Univ, New Jersey Med Sch, Ctr Human Dev & Aging, Newark, NJ 07102 USA.
   [Christensen, Kaare] Univ Southern Denmark, Danish Twin Registry, Odense, Denmark.
   [Christensen, Kaare] Odense Univ Hosp, Dept Clin Genet, DK-5000 Odense, Denmark.
   [Christensen, Kaare] Odense Univ Hosp, Dept Biochem & Clin Pharmacol, DK-5000 Odense, Denmark.
   [Kyvik, Kirsten O.] Univ Southern Denmark, Dept Clin Res, Odense, Denmark.
   [Kyvik, Kirsten O.] Odense Univ Hosp, Odense Patient Data Explorat Network OPEN, DK-5000 Odense, Denmark.
   [Benetos, Athanase] CHU Nancy, Dept Geriatr Med, F-54511 Vandoeuvre Les Nancy, France.
C3 University of Groningen; University of Southern Denmark; Universite de
   Lorraine; Institut National de la Sante et de la Recherche Medicale
   (Inserm); Universite de Lorraine; Hebrew University of Jerusalem;
   Rutgers University System; Rutgers University Newark; Rutgers University
   New Brunswick; Rutgers University Biomedical & Health Sciences;
   University of Southern Denmark; University of Southern Denmark; Odense
   University Hospital; University of Southern Denmark; Odense University
   Hospital; University of Southern Denmark; University of Southern
   Denmark; Odense University Hospital; CHU de Nancy
RP Benetos, A (corresponding author), INSERM, U1116, Vandoeuvre Les Nancy, France.; Benetos, A (corresponding author), Univ Lorraine, Nancy, France.
EM a.benetos@chu-nancy.fr
RI Benetos, Athanase/JJC-4282-2023; Verhulst, Simon/S-3404-2019;
   Christensen, Kaare/C-2360-2009; Kyvik, Kirsten Ohm/K-5680-2016; Labat,
   Carlos/F-7492-2010
OI Christensen, Kaare/0000-0002-5429-5292; Kyvik, Kirsten
   Ohm/0000-0003-2981-0245; Dalgard, Christine/0000-0001-8184-3429; Labat,
   Carlos/0000-0002-5275-3405; Verhulst, Simon/0000-0002-1143-6868;
   Toupance, Simon/0000-0001-7441-567X
FU NIH [AG030678, HD071180]; Danish Council for Independent Research -
   Medical Sciences; INTERREG 4 A - programme Southern
   Denmark-Schleswig-K.E.R.N. - European Regional Development Fund; A.P.
   Moller Foundation for the Advancement of Medical Science; French
   National Research Agency (ANR) [RCB: 2014-A00298-39: 2014-2017]
FX This work was supported by NIH grants AG030678 and HD071180; the Danish
   Council for Independent Research - Medical Sciences; the INTERREG 4 A -
   programme Southern Denmark-Schleswig-K.E.R.N. supported by the European
   Regional Development Fund; and the A.P. Moller Foundation for the
   Advancement of Medical Science. This study has been supported by the
   French National Research Agency (ANR), Translationnelle: NoID RCB:
   2014-A00298-39: 2014-2017.
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NR 44
TC 75
Z9 79
U1 0
U2 7
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0012-186X
EI 1432-0428
J9 DIABETOLOGIA
JI Diabetologia
PD JUN
PY 2016
VL 59
IS 6
BP 1258
EP 1265
DI 10.1007/s00125-016-3915-6
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA DO8QN
UT WOS:000378048500024
PM 27020448
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Cho, Y
   Kim, DH
   Choi, J
   Lee, JK
   Roh, YK
   Nam, HY
   Nam, GE
   Kim, DW
   Lee, SH
   Lee, CW
   Han, K
   Park, YG
AF Cho, Yunji
   Kim, Do Hoon
   Choi, June
   Lee, Joo Kyung
   Roh, Yong-Kyun
   Nam, Hyo-Yun
   Nam, Ga-Eun
   Kim, Dong-Won
   Lee, Seung-Hyun
   Lee, Chung-Woo
   Han, Kyungdo
   Park, Yong-Gyu
TI Glomerular Filtration Rate and Urine Albumin to Creatinine Ratio
   Associated With Hearing Impairment Among Korean Adults With Diabetes
   A Nationwide Population-Based Study
SO MEDICINE
LA English
DT Article
ID NUTRITION EXAMINATION SURVEY; CHRONIC KIDNEY-DISEASE; CARDIOVASCULAR
   RISK-FACTORS; US ADULTS; INNER-EAR; COLLABORATIVE METAANALYSIS;
   RENAL-FAILURE; ALL-CAUSE; HEALTH; MELLITUS
AB The objective of this study was to examine the association of estimated glomerular filtration rate (eGFR) and urine albumin to creatinine ratio (ACR) with hearing impairment among diabetic adults in Korea. The study was based on data from Korea National Health and Nutrition Examination Survey 2011 to 2012. Participants were 1206 diabetic adults, aged over 19 years, who completed audiometric testing supervised by nationally certified clinicians. Hearing impairment was defined in three grades: no hearing impairment (pure-tone average 025 dB), slight hearing impairment (26-40 dB), and disabling hearing impairment (> 40 dB) in the better ear at frequencies 0.5,1, 2, 3, 4 and 6 kHz. Using logistic regression, risk of hearing impairment was assessed after having controlled for confounding factors. Higher levels of ACR and lower levels of eGFR correlated with an increase in percentage of disabling hearing impairment both unilaterally and bilaterally (P<0.001). Controlling for possible confounding covariates, odds ratios for hearing impairment showed tendency to increase in higher ACR groups (P for trend = 0.029). Similar pattern was examined between eGFR and hearing impairment (P for trend = 0.006). Odds ratios were 1.981 (1.146, 3.424) for ACR Q4 and 2.773 (1.286, 5.983) for eGFR < 60 mL/min. Fall in eGFR and rise in ACR correlated with severity of hearing impairment. The association existed independently of age, sex, body mass index (BMI), smoking, drinking, exercise, new onset of diabetes, education, income, mental stress, noise exposure, and metabolic syndrome.
C1 [Cho, Yunji; Lee, Joo Kyung] Korea Univ, Coll Med, Ansan 425707, Gyeonggi Do, South Korea.
   [Cho, Yunji; Kim, Do Hoon; Nam, Hyo-Yun; Nam, Ga-Eun; Kim, Dong-Won; Lee, Seung-Hyun; Lee, Chung-Woo] Korea Univ, Dept Family Med, Ansan 425707, Gyeonggi Do, South Korea.
   [Choi, June] Korea Univ, Dept Otorhinolaryngol Head & Neck Surg, Ansan 425707, Gyeonggi Do, South Korea.
   [Roh, Yong-Kyun] Hallym Univ, Coll Med, Dept Family Med, Chunchon, South Korea.
   [Han, Kyungdo; Park, Yong-Gyu] Catholic Univ, Dept Biostat, Coll Med, Seoul, South Korea.
C3 Korea University; Korea University Medicine (KU Medicine); Korea
   University; Korea University; Hallym University; Catholic University of
   Korea
RP Kim, DH (corresponding author), Korea Univ, Coll Med, Ansan Hosp, Dept Family Med, 123 Jeokgeum Ro, Ansan 425707, Gyeonggi Do, South Korea.; Choi, J (corresponding author), Korea Univ, Coll Med, Ansan Hosp, Dept Otorhinolaryngol Head & Neck Surg, 123 Jeokgeum Ro, Ansan 425707, Gyeonggi Do, South Korea.
EM kmcfm@hanmail.net; mednlaw@korea.ac.kr
RI KIM, DONG WON/AFL-8454-2022; Nam, Ga Eun/AAU-6055-2020; Kim,
   Yeseul/AFP-0108-2022; Choi, June/E-7063-2013
OI Park, Yong Gyu/0000-0002-8721-3230; Nam, Ga Eun/0000-0002-6739-9904;
   Kim, Do Hoon/0000-0001-7421-4501; CHOI, JUNE/0000-0002-6330-279X
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NR 37
TC 14
Z9 14
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD APR
PY 2016
VL 95
IS 17
AR e3423
DI 10.1097/MD.0000000000003423
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA DN2XF
UT WOS:000376925600015
PM 27124027
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Komiyama, M
   Shimada, S
   Wada, H
   Yamakage, H
   Satoh-Asahara, N
   Shimatsu, A
   Akao, M
   Morimoto, T
   Takahashi, Y
   Hasegawa, K
AF Komiyama, Maki
   Shimada, Sayaka
   Wada, Hiromichi
   Yamakage, Hajime
   Satoh-Asahara, Noriko
   Shimatsu, Akira
   Akao, Masaharu
   Morimoto, Tatsuya
   Takahashi, Yuko
   Hasegawa, Koji
TI Time-dependent Changes of Atherosclerotic LDL Complexes after Smoking
   Cessation
SO JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
LA English
DT Article
DE Smoking Cessation; Obesity; Oxidative stress; Atherosclerosis;
   Prevention
ID SERUM-AMYLOID-A; DENSITY-LIPOPROTEIN LEVELS; CARDIOVASCULAR-DISEASE;
   NICOTINE DEPENDENCE; METABOLIC SYNDROME; WEIGHT-GAIN; MARKER;
   ALPHA(1)-ANTITRYPSIN; ALPHA-1-ANTITRYPSIN; ASSOCIATION
AB Aim: The alpha 1-antitrypsin-low-density lipoprotein complex (AT-LDL) and serum amyloid A-LDL complex (SAA-LDL) are oxidatively modified LDL complexes that promote atherosclerosis. The serum levels of AT-LDL and SAA-LDL are suggested to be increased by obesity and smoking. We have previously demonstrated that larger weight gain after smoking cessation (SC) perturbs a decrease in the serum level of AT-LDL at 3 months after SC. However, changes of these atherosclerotic makers > 3 months after SC are unknown. This study investigated post-SC time-dependent changes in two atherogenic lipoproteins, AT-LDL and SAA-LDL, and in the extent of abdominal obesity.
   Methods: In 50 outpatients who had continued SC for 1 year, we measured serum AT-LDL and SAALDL levels by the enzyme-linked immunosorbent assay before SC, and at 3 months and 1 year after SC.
   Results: Both body mass index and waist circumstance significantly increased from pre-SC to 3 months after SC and from 3 months after SC to 1 year after SC. Although the serum levels of ATLDL and SAA-LDL were unchanged from pre-SC to 3 months after SC, these levels decreased significantly from 3 months after SC to 1 year after SC.
   Conclusions: The extent of abdominal obesity and levels of two atherogenic lipoproteins timedependently change after SC. Although abdominal obesity progressively worsened after SC, the beneficial effect of non-smoking overcomes the potential vascular risks by cessation-associated obesity at 1 year after SC.
C1 [Komiyama, Maki; Shimada, Sayaka; Wada, Hiromichi; Yamakage, Hajime; Satoh-Asahara, Noriko; Shimatsu, Akira; Akao, Masaharu; Hasegawa, Koji] Natl Hosp Org, Kyoto Med Ctr, Clin Res Inst, Kyoto, Japan.
   [Morimoto, Tatsuya] Univ Shizuoka, Sch Pharmaceut Sci, Div Mol Med, Shizuoka, Japan.
   [Takahashi, Yuko] Nara Womens Univ, Hlth Care Ctr, Nara, Japan.
C3 University of Shizuoka; Nara Womens University
RP Hasegawa, K (corresponding author), Natl Hosp Org, Kyoto Med Ctr, Clin Res Inst, Div Translat Res,Fushimi Ku, 1-1 Mukaihata Cho, Kyoto 6128555, Japan.
EM koj@kuhp.kyoto-u.ac.jp
RI Shimatsu, Akira/I-3856-2019; TAKAHASHI, Yuko/GYR-2934-2022
OI Komiyama, Maki/0000-0002-8827-3315; Wada, Hiromichi/0000-0002-8980-224X
FU National Hospital Organization
FX We thank Yuko Iida and Sachiko Terashima for technical assistance and
   Noa Nagaoka for secretarial assistance. This work was supported in part
   by a Grant-in-Aid for Clinical Research from the National Hospital
   Organization. The funders played no role in the study design, data
   collection and analysis, decision to publish, or preparation of the
   manuscript.
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NR 25
TC 18
Z9 19
U1 0
U2 3
PU JAPAN ATHEROSCLEROSIS SOC
PI TOKYO
PA NICHINAI-KAIKAN B1, 3-28-8 HONGO BUNKYO-KU, TOKYO, 113-0033, JAPAN
SN 1340-3478
EI 1880-3873
J9 J ATHEROSCLER THROMB
JI J. Atheroscler. Thromb.
PY 2016
VL 23
IS 11
BP 1270
EP 1275
DI 10.5551/jat.34280
PG 6
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA EF3CY
UT WOS:000390203300005
PM 27298048
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Viguiliouk, E
   Stewart, SE
   Jayalath, VH
   Ng, AP
   Mirrahimi, A
   de Souza, RJ
   Hanley, AJ
   Bazinet, RP
   Mejia, SB
   Leiter, LA
   Josse, RG
   Kendall, CWC
   Jenkins, DJA
   Sievenpiper, JL
AF Viguiliouk, Effie
   Stewart, Sarah E.
   Jayalath, Viranda H.
   Ng, Alena Praneet
   Mirrahimi, Arash
   de Souza, Russell J.
   Hanley, Anthony J.
   Bazinet, Richard P.
   Mejia, Sonia Blanco
   Leiter, Lawrence A.
   Josse, Robert G.
   Kendall, Cyril W. C.
   Jenkins, David J. A.
   Sievenpiper, John L.
TI Effect of Replacing Animal Protein with Plant Protein on Glycemic
   Control in Diabetes: A Systematic Review and Meta-Analysis of Randomized
   Controlled Trials
SO NUTRIENTS
LA English
DT Article
DE plant protein; animal protein; diabetes; glycemic control
ID BODY IRON STORES; SOY PROTEIN; INSULIN SENSITIVITY; METABOLIC SYNDROME;
   OXIDATIVE STRESS; VEGETARIAN DIETS; MEAT CONSUMPTION; ADVENTIST HEALTH;
   SERUM FERRITIN; RENAL-FUNCTION
AB Previous research on the effect of replacing sources of animal protein with plant protein on glycemic control has been inconsistent. We therefore conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) to assess the effect of this replacement on glycemic control in individuals with diabetes. We searched MEDLINE, EMBASE, and Cochrane databases through 26 August 2015. We included RCTs 3-weeks comparing the effect of replacing animal with plant protein on HbA(1c), fasting glucose (FG), and fasting insulin (FI). Two independent reviewers extracted relevant data, assessed study quality and risk of bias. Data were pooled by the generic inverse variance method and expressed as mean differences (MD) with 95% confidence intervals (CIs). Heterogeneity was assessed (Cochran Q-statistic) and quantified (I-2-statistic). Thirteen RCTs (n = 280) met the eligibility criteria. Diets emphasizing a replacement of animal with plant protein at a median level of similar to 35% of total protein per day significantly lowered HbA(1c) (MD = -0.15%; 95%-CI: -0.26, -0.05%), FG (MD = -0.53 mmol/L; 95%-CI: -0.92, -0.13 mmol/L) and FI (MD = -10.09 pmol/L; 95%-CI: -17.31, -2.86 pmol/L) compared with control arms. Overall, the results indicate that replacing sources of animal with plant protein leads to modest improvements in glycemic control in individuals with diabetes. Owing to uncertainties in our analyses there is a need for larger, longer, higher quality trials. Trial Registration: ClinicalTrials.gov registration number: NCT02037321.
C1 [Viguiliouk, Effie; Stewart, Sarah E.; Jayalath, Viranda H.; Ng, Alena Praneet; Mirrahimi, Arash; de Souza, Russell J.; Mejia, Sonia Blanco; Leiter, Lawrence A.; Josse, Robert G.; Kendall, Cyril W. C.; Jenkins, David J. A.; Sievenpiper, John L.] St Michaels Hosp, Toronto Knowledge Synth & Clin Trials Unit 3D, Clin Nutr & Risk Factor Modificat Ctr, Toronto, ON M5C 2T2, Canada.
   [Viguiliouk, Effie; Stewart, Sarah E.; de Souza, Russell J.; Hanley, Anthony J.; Bazinet, Richard P.; Mejia, Sonia Blanco; Leiter, Lawrence A.; Josse, Robert G.; Kendall, Cyril W. C.; Jenkins, David J. A.; Sievenpiper, John L.] Univ Toronto, Dept Nutr Sci, Fac Med, Toronto, ON M5S 2E8, Canada.
   [Jayalath, Viranda H.] Univ Hlth Network, Princess Margaret Canc Ctr, Dept Surg Oncol, Toronto, ON M5G 2C4, Canada.
   [Jayalath, Viranda H.] Univ Toronto, Undergrad Med Educ, Toronto, ON M5S 2E8, Canada.
   [Mirrahimi, Arash] Queens Univ, Sch Med, Fac Hlth Sci, Kingston, ON K7L 3N6, Canada.
   [de Souza, Russell J.] McMaster Univ, Fac Hlth Sci, Dept Clin Epidemiol & Biostat, Hamilton, ON L8S 4L8, Canada.
   [Hanley, Anthony J.] Mt Sinai Hosp, Leadership Sinai Ctr Diabet, Toronto, ON M5G 1X5, Canada.
   [Hanley, Anthony J.; Leiter, Lawrence A.; Josse, Robert G.; Jenkins, David J. A.] Univ Toronto, Dept Med, Toronto, ON M5S 2E8, Canada.
   [Hanley, Anthony J.] Univ Toronto, Dalla Lana Sch Publ Hlth, Toronto, ON M5S 2E8, Canada.
   [Leiter, Lawrence A.; Josse, Robert G.; Jenkins, David J. A.; Sievenpiper, John L.] St Michaels Hosp, Div Endocrinol & Metab, Toronto, ON M5C 2T2, Canada.
   [Leiter, Lawrence A.; Josse, Robert G.; Jenkins, David J. A.; Sievenpiper, John L.] St Michaels Hosp, Li Ka Shing Knowledge Inst, Toronto, ON M5C 2T2, Canada.
   [Kendall, Cyril W. C.] Univ Saskatchewan, Coll Pharm & Nutr, Saskatoon, SK S7N 5A2, Canada.
C3 University of Toronto; Saint Michaels Hospital Toronto; University of
   Toronto; University of Toronto; University Health Network Toronto;
   Princess Margaret Cancer Centre; University of Toronto; Queens
   University - Canada; McMaster University; University of Toronto; Sinai
   Health System Toronto; Lunenfeld Tanenbaum Research Institute;
   University of Toronto; University of Toronto; University of Toronto;
   Saint Michaels Hospital Toronto; University of Toronto; Li Ka Shing
   Knowledge Institute; Saint Michaels Hospital Toronto; University of
   Saskatchewan
RP Sievenpiper, JL (corresponding author), St Michaels Hosp, Toronto Knowledge Synth & Clin Trials Unit 3D, Clin Nutr & Risk Factor Modificat Ctr, Toronto, ON M5C 2T2, Canada.
EM effie.viguiliouk@mail.utoronto.ca; sarahe.stewart@mail.utoronto.ca;
   viranda.jayalath@mail.utoronto.ca; alena.ng@mail.utoronto.ca;
   smirrahimi@qmed.ca; rdesouz@mcmaster.ca; anthony.hanley@utoronto.ca;
   richard.bazinet@utoronto.ca; BlancoMejiaS@smh.ca; LeiterL@smh.ca;
   JosseRG@smh.ca; cyril.kendall@utoronto.ca; NutritionProject@smh.ca;
   john.sievenpiper@utoronto.ca
RI Jenkins, David/N-3090-2017; Leiter, Lawrence/AAG-4059-2020; Rao,
   Jagadeesh/GRN-8594-2022; Sievenpiper, John/JVN-7555-2024; de Souza,
   Russell/ABB-7735-2021
OI de Souza, Russell/0000-0001-8945-513X; Jayalath,
   Viranda/0009-0009-0062-8512
FU Canadian Institutes of Health Research through the Canada-wide Human
   Nutrition Trialists' Network (NTN) [129,920]; Canadian Institutes of
   Health Research (CIHR)-Fredrick Banting and Charles Best Canada Graduate
   Scholarship; Banting and Best Diabetes Centre (BBDC)-Yow Kam-Yuen
   Graduate Scholarship in Diabetes Research; Government of Canada through
   the Canada Research Chair Endowment; PSI Foundation Graham Farquharson
   Knowledge Translation Fellowship; Canadian Diabetes Association (CDA)
   Clinician Scientist Award; Canada Foundation for Innovation (CFI);
   Ministry of Research and Innovation's Ontario Research Fund (ORF)
FX We wish to thank Teruko Kishibe of Li Ka Shing's International
   Healthcare Education Centre at St. Michael Hospital for her help in the
   development of the search strategy. This work was supported by the
   Canadian Institutes of Health Research (funding reference number:
   129,920) through the Canada-wide Human Nutrition Trialists' Network
   (NTN). Effie Viguiliouk was funded by a Canadian Institutes of Health
   Research (CIHR)-Fredrick Banting and Charles Best Canada Graduate
   Scholarship and the Banting and Best Diabetes Centre (BBDC)-Yow Kam-Yuen
   Graduate Scholarship in Diabetes Research. Anthony J. Hanley, Richard P.
   Bazinet and David J. A. Jenkins were funded by the Government of Canada
   through the Canada Research Chair Endowment. John L Sievenpiper was
   funded by the PSI Foundation Graham Farquharson Knowledge Translation
   Fellowship and Canadian Diabetes Association (CDA) Clinician Scientist
   Award. The Diet, Digestive tract, and Disease (3-D) Centre, funded
   through the Canada Foundation for Innovation (CFI) and the Ministry of
   Research and Innovation's Ontario Research Fund (ORF) provided the
   infrastructure for the conduct of this project. None of the sponsors had
   a role in any aspect of the present study, including design and conduct
   of the study; collection, management, analysis, and interpretation of
   the data; and preparation, review, and approval of the manuscript or
   decision to publish.
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NR 68
TC 96
Z9 102
U1 3
U2 40
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD DEC
PY 2015
VL 7
IS 12
BP 9804
EP 9824
DI 10.3390/nu7125509
PG 21
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA CZ4DA
UT WOS:000367052200007
PM 26633472
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Ghizoni, H
   Figueiredo, PM
   Moisan, MP
   Ogias, D
   Osaki, LH
   Gama, P
AF Ghizoni, Heloisa
   Figueiredo, Priscila Moreira
   Moisan, Marie-Pierre
   Ogias, Daniela
   Osaki, Luciana Harumi
   Gama, Patricia
TI Regulation of corticosterone function during early weaning and effects
   on gastric cell proliferation
SO NUTRITION
LA English
DT Article
DE Corticosterone; Glucocorticoid receptor; Corticosteroid-binding
   globulin; Cell proliferation; Gastric mucosa
ID BINDING-GLOBULIN; GLUCOCORTICOID-RECEPTOR; ORNITHINE-DECARBOXYLASE;
   METABOLIC SYNDROME; DEVELOPING RATS; SUCKLING RATS; INFANT RAT;
   EPITHELIUM; EXPRESSION; STRESS
AB Objectives: The development of the gastrointestinal tract depends on many elements, including glucocorticoids. In the current study, we evaluated the effects of early weaning on corticosterone function and the growth of rat gastric mucosa.
   Methods: By using Wistar rats submitted to early weaning at 15 d, we analyzed plasma corticosterone, corticosteroid-binding globulin (CBG), and glucocorticoid receptor (GR) distribution in the gastric epithelium.
   Results: With the use of radioimmunoassay, we found that early weaning increased corticosterone concentration at day 16 and 17 in test subjects as compared with controls, whereas it was equivalent between groups at day 18. CBG binding capacity decreased during treatment, and it was significantly lower at day 18. At this age, GR levels and distribution in the gastric mucosa were also reduced as compared with suckling counterparts. To reduce corticosterone activity during early weaning and to explore cell proliferation responses, we administered RU486 to 15-d-old pups. We found that cytoplasmic GR reached a peak after 48 h, whereas nuclear levels remained constant, thereby confirming the inhibition of receptor function. Next, by checking gastric proliferative responses, we observed that RU486 induced higher DNA synthesis and mitotic indices in test subjects as compared with control groups.
   Conclusions: We demonstrated that early weaning changed corticosterone activity by increasing hormone levels, reducing CBG binding capacity, and decreasing GR distribution in the gastric epithelium. These modifications seem to be important to the reorganization of gastric growth after the abrupt interruption of suckling. (C) 2014 Elsevier Inc. All rights reserved.
C1 [Ghizoni, Heloisa; Figueiredo, Priscila Moreira; Ogias, Daniela; Osaki, Luciana Harumi; Gama, Patricia] Univ Sao Paulo, Inst Biomed Sci, Dept Cell & Dev Biol, Sao Paulo, Brazil.
   [Moisan, Marie-Pierre] INRA, UMR 1286, Bordeaux, France.
   [Moisan, Marie-Pierre] Univ Bordeaux, UMR 1286, Bordeaux, France.
C3 Universidade de Sao Paulo; Institute Biomed Science, University Sao
   Paulo; Institut National de la Sante et de la Recherche Medicale
   (Inserm); Universite de Bordeaux; INRAE; Universite de Bordeaux;
   Institut National de la Sante et de la Recherche Medicale (Inserm)
RP Gama, P (corresponding author), Univ Sao Paulo, Inst Biomed Sci, Dept Cell & Dev Biol, Sao Paulo, Brazil.
EM patgama@usp.br
RI Figueiredo, Priscila/JBS-1673-2023; ogias, daniela/D-9256-2012; Osaki,
   Luciana/I-3624-2012; Moisan, Marie-Pierre/AAO-9971-2021; Gama,
   Patricia/D-4756-2012
OI Moisan, Marie-Pierre/0000-0001-7315-5319; Osaki,
   Luciana/0000-0003-0665-7567; Gama, Patricia/0000-0002-1863-893X
FU Sao Paulo Research Foundation (FAPESP) [2009/00272-5, 2011/17415-3,
   2010/03059-8]; Brazil's National Council for Scientific and
   Technological Development (CNPq) [476370/2008-6]; Formas [2009-00272]
   Funding Source: Formas; Fundacao de Amparo a Pesquisa do Estado de Sao
   Paulo (FAPESP) [10/03059-8] Funding Source: FAPESP
FX The authors thank Cruz Alberto Mendoza Rigonati for histologic sections
   and Marlene Santos da Rocha for technical support for the
   radioimmunoassay. This study was supported by grants (2009/00272-5;
   2011/17415-3) and fellowships to H.G. (2010/03059-8) and P.M.F.
   (2008/03301-3) from the Sao Paulo Research Foundation (FAPESP) as well
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NR 51
TC 12
Z9 12
U1 0
U2 7
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0899-9007
EI 1873-1244
J9 NUTRITION
JI Nutrition
PD MAR
PY 2014
VL 30
IS 3
BP 343
EP 349
DI 10.1016/j.nut.2013.09.003
PG 7
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA AB2BN
UT WOS:000331598100016
PM 24484684
DA 2025-06-11
ER

PT J
AU Barrett-Connor, E
AF Barrett-Connor, Elizabeth
TI Gender differences and disparities in all-cause and coronary heart
   disease mortality: Epidemiological aspects
SO BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Article
DE coronary heart disease; diabetes; gender differences; lifestyle; stress;
   testosterone
ID BODY-MASS INDEX; ENDOGENOUS SEX-HORMONES; DIABETES-MELLITUS;
   RISK-FACTOR; COLLABORATIVE METAANALYSIS; CARDIOVASCULAR-DISEASES;
   MYOCARDIAL-INFARCTION; TESTOSTERONE LEVELS; RANCHO-BERNARDO;
   NATIONAL-HEALTH
AB This overview is primarily concerned with large recent prospective cohort studies of adult populations, not patients, because the latter studies are confounded by differences in medical and surgical management for men vs. women. When early papers are uniquely informative they are also included. Because the focus is on epidemiology, details of age, sex, sample size, and source as well as study methods are provided. Usually the primary outcomes were all-cause or coronary heart disease (CHD) mortality using baseline data from midlife or older adults.
   Fifty years ago few prospective cohort studies of all-cause or CHD mortality included women. Most epidemiologic studies that included community-dwelling adults did not include both sexes and still do not report men and women separately. Few studies consider both sex (biology) and gender (behavior and environment) differences. Lifespan studies describing survival after live birth are not considered here. The important effects of prenatal and early childhood biologic and behavioral factors on adult mortality are beyond the scope of this review. Clinical trials are not discussed.
   Overall, presumptive evidence for causality was equivalent for psychosocial and biological exposures, and these attributes were often associated with each other. Inconsistencies or gaps were particularly obvious for studies of sex or gender differences in age and optimal measures of body size for CHD outcomes, and in the striking interface of diabetes and people with the metabolic syndrome, most of whom have unrecognized diabetes. (C) 2013 Elsevier Ltd. All rights reserved.
C1 [Barrett-Connor, Elizabeth] Univ Calif San Diego, Dept Family & Prevent Med, Div Epidemiol, La Jolla, CA 92093 USA.
C3 University of California System; University of California San Diego
RP Barrett-Connor, E (corresponding author), Univ Calif San Diego, Dept Family & Prevent Med, 9500 Gilman Dr, La Jolla, CA 92093 USA.
EM ebarrettconnor@ucsd.edu
FU National Institute on Aging [AG07181, AG028507]; National Institute of
   Diabetes and Digestive and Kidney Diseases [DK31801]
FX Elizabeth Barrett-Connor is Principle Investigator of The Rancho
   Bernardo Study, which was funded by research grants AG07181 and AG028507
   from the National Institute on Aging, and grant DK31801 from the
   National Institute of Diabetes and Digestive and Kidney Diseases.
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NR 57
TC 41
Z9 45
U1 0
U2 14
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1521-690X
J9 BEST PRACT RES CL EN
JI Best Pract. Res. Clin. Endoc. Metab.
PD AUG
PY 2013
VL 27
IS 4
BP 481
EP 500
DI 10.1016/j.beem.2013.05.013
PG 20
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism
GA 231BE
UT WOS:000325387200003
PM 24054926
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Mangge, H
   Summers, K
   Almer, G
   Prassl, R
   Weghuber, D
   Schnedl, W
   Fuchs, D
AF Mangge, H.
   Summers, K.
   Almer, G.
   Prassl, R.
   Weghuber, D.
   Schnedl, W.
   Fuchs, D.
TI Antioxidant Food Supplements and Obesity-Related Inflammation
SO CURRENT MEDICINAL CHEMISTRY
LA English
DT Article
DE Antioxidants; obesity; inflammation; oxidative stress; food supplements;
   leptin; Th1; tryptophan; serotonin; melatonin
ID CHRONIC IMMUNE ACTIVATION; METABOLIC SYNDROME; INTERFERON-GAMMA; LEPTIN
   RECEPTOR; PLASMA LEPTIN; DIETARY-FAT; TRYPTOPHAN DEPLETION;
   SLEEP-DEPRIVATION; SODIUM-SULFITE; MORBID-OBESITY
AB The obesity prevalence is growing worldwide and largely responsible for the increased incidence of cardiovascular disease, the most common cause of death in the western world. Excessive food intake along with insufficient physical exercise is the basic impetus for this development. The obese state is commonly associated with an increase in leptin levels and chronic immune-mediated inflammation. Despite high leptin levels, the leptin response, normally associated with satiety and satiation, seems to be impaired and individuals continue to consume calorie-rich food. Antioxidant food additives such as sodium sulphite, sodium benzoate and curcumin were shown to suppress the leptin release in lipopolysaccharide-treated murine adipocytes. Based on this, we hypothesize that the insufficient leptin release, caused by excessive consumption of food additives, may lead to a reduced exposure of the central nervous system to leptin and ultimately propagate obesity. On the other hand, leptin has been shown to favor Th1-type activity, which ultimately decreases tryptophan levels. Tryptophan derivatives, serotonin and melatonin, induce satiety/satiation through several mechanisms. In this context, the antioxidant suppression of leptin release and Th1-type activity is beneficial to increase serotonin and melatonin levels. The molecules in the mechanism described in this review are highly integrated in the reward system, and have been implicated in the addiction behavior of obesity. Based on these facts, the involvement of antioxidant food supplements in the mechanisms of the reward-deficiency syndrome which perpetuates obesity will be discussed.
C1 [Mangge, H.; Summers, K.; Almer, G.] Med Univ Graz, Clin Inst Med & Chem Lab Diag, A-8036 Graz, Austria.
   [Prassl, R.] Med Univ Graz, Inst Biophys, A-8036 Graz, Austria.
   [Weghuber, D.] Paracelsus Private Med Sch Salzburg, Dept Pediat, Salzburg, Austria.
   [Fuchs, D.] Med Univ Innsbruck, Bioctr, Div Biol Chem, A-6020 Innsbruck, Austria.
C3 Medical University of Graz; Medical University of Graz; Paracelsus
   Private Medical University; Medical University of Innsbruck
RP Mangge, H (corresponding author), Med Univ Graz, Clin Inst Med & Chem Lab Diag, Res Unit Lifestyle & Inflammation Associated Risk, Auenbruggerpl 30, A-8036 Graz, Austria.
EM harald.mangge@klinikum-graz.at
RI Weghuber, Daniel/AAN-1422-2020; Fuchs, Dietmar/AAL-8011-2021; Almer,
   Gunter/G-3253-2013; Prassl, Ruth/AAE-1523-2021
OI Mangge, Harald/0000-0003-4067-247X; Schnedl,
   Wolfgang/0000-0002-5212-5230; Prassl, Ruth/0000-0002-1010-9494
FU Austrian Nano-Initiative; Nano-Health Project [819721]; Austrian
   Research Agency FFG; Austrian Science Fund FWF [SFB F1808-B13, CCHD
   APW01205FW]
FX This work was supported by the Austrian Nano-Initiative, who co-financed
   this work as part of the Nano-Health Project 819721 granted by the
   Austrian Research Agency FFG, and the Austrian Science Fund FWF (SFB
   F1808-B13; CCHD APW01205FW).
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   EMIRATES
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J9 CURR MED CHEM
JI Curr. Med. Chem.
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PY 2013
VL 20
IS 18
BP 2330
EP 2337
DI 10.2174/0929867311320180004
PG 8
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Pharmacology &
   Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
GA 138CO
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DA 2025-06-11
ER

PT J
AU Tindle, H
   Davis, E
   Kuller, L
AF Tindle, Hilary
   Davis, Esa
   Kuller, Lewis
TI Attitudes and cardiovascular disease
SO MATURITAS
LA English
DT Review
DE Attitudes; Optimism; Pessimism; Cynical hostility; Lifecourse;
   Cardiovascular disease (CVD)
ID CORONARY-HEART-DISEASE; PERCEIVED SOCIAL SUPPORT; C-REACTIVE PROTEIN;
   MIDDLE-AGED WOMEN; DISPOSITIONAL OPTIMISM; METABOLIC SYNDROME;
   MYOCARDIAL-INFARCTION; POSTMENOPAUSAL WOMEN; CAROTID ATHEROSCLEROSIS;
   INFLAMMATORY MARKERS
AB Psychological attitudes are prospectively related to cardiovascular disease (CVD), but a causal relationship has not been demonstrated. Trait optimism/pessimism (positive or negative future expectation, respectively), and cynical hostility (mistrust of people), are attitudes with features of personality traits. These attitudes may affect CVD risk in several ways, by influencing an individual's (1) adoption of health behaviors, (2) maladaptive stress responding resulting in direct alteration of physiology (i.e., autonomic dysfunction, thrombosis, arrhythmias), (3) development of traditional CVD risk factors, and (4) lack of adherence to therapy in both primary and secondary prevention. More adaptive attitudes may favorably influence CVD risk at each of these critical junctures. The genetic and environmental (i.e., social, economic, racial/ethnic) determinants of attitudes have not been extensively studied. In addition, it is important to understand how some of these environmental determinants may also moderate the association between attitudes and CVD. Clinical trials to modify attitudes for CVD risk reduction (either by reducing negative attitudes or by increasing positive attitudes) are difficult to conduct, but are necessary to determine whether attitudes can indeed be modified, and if, so, to quantify any CVD-related benefits. To address these questions we present a broad, multidisciplinary research agenda utilizing mixed methods and integrating principles of epidemiology, genetics, psychophysiology, and behavioral medicine over the lifecourse (first figure). This overview focuses on attitudes and CVD, but has broader implications for understanding how psychological factors relate to chronic diseases of adulthood. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
C1 [Tindle, Hilary; Davis, Esa] Univ Pittsburgh, Div Gen Internal Med, Pittsburgh, PA 15213 USA.
   [Kuller, Lewis] Univ Pittsburgh, Dept Epidemiol, Grad Sch Publ Hlth, Pittsburgh, PA 15213 USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE); University
   of Pittsburgh; Pennsylvania Commonwealth System of Higher Education
   (PCSHE); University of Pittsburgh
RP Tindle, H (corresponding author), Univ Pittsburgh, Div Gen Internal Med, 230 McKee Pl,Suite 600, Pittsburgh, PA 15213 USA.
EM tindleha@upmc.edu; davism@upmc.edu; kullerl@edc.pitt.edu
FU National Center for Research Resources (NCRR), National Institutes of
   Health (NIH) [KL2 RR024154]; NIH Roadmap for Medical Research
FX This publication was made possible by Grant Number KL2 RR024154 (Dr.
   Tindle) from the National Center for Research Resources (NCRR), a
   component of the National Institutes of Health (NIH), and NIH Roadmap
   for Medical Research. Its contents are solely the responsibility of the
   authors and do not necessarily represent the official view of NCRR or
   NIH. Information on NCRR is available at http://www.ncrr.nih.gov/.
   Information on Re-engineering the Clinical Research Enterprise can be
   obtained from
   http://nihroadmap.nih.gov/clinicalresearch/overview-translational.asp.
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TC 46
Z9 55
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U2 22
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0378-5122
EI 1873-4111
J9 MATURITAS
JI Maturitas
PD OCT
PY 2010
VL 67
IS 2
BP 108
EP 113
DI 10.1016/j.maturitas.2010.04.020
PG 6
WC Geriatrics & Gerontology; Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Obstetrics & Gynecology
GA 663ZY
UT WOS:000282929900004
PM 20554132
OA Green Accepted, Green Published
DA 2025-06-11
ER

PT S
AU Suliman, ME
   García-López, E
   Anderstam, B
   Lindholm, B
   Stenvinkel, P
AF Suliman, Mohamed E.
   Garcia-Lopez, Elvia
   Anderstam, Bjoern
   Lindholm, Bengt
   Stenvinkel, Peter
BE Makowski, GS
TI VASCULAR CALCIFICATION INHIBITORS IN RELATION TO CARDIOVASCULAR DISEASE
   WITH SPECIAL EMPHASIS ON FETUIN-A IN CHRONIC KIDNEY DISEASE
SO ADVANCES IN CLINICAL CHEMISTRY, VOL 46
SE Advances in Clinical Chemistry
LA English
DT Review; Book Chapter
ID MATRIX-GLA-PROTEIN; CORONARY-ARTERY CALCIFICATION; BONE MORPHOGENETIC
   PROTEIN-7; SERUM OSTEOPROTEGERIN LEVELS; STAGE RENAL-DISEASE;
   SMOOTH-MUSCLE-CELLS; ALPHA(2)-HEREMANS-SCHMID GLYCOPROTEIN/FETUIN-A;
   HUMAN ALPHA-2-HS GLYCOPROTEIN; CARBOXYGLUTAMIC ACID PROTEIN;
   AORTIC-VALVE CALCIFICATION
AB The mortality rate is extremely high in chronic kidney disease (CKD). primarily due to the high prevalence of cardiovascular disease (CVD) in this patient group. Apart from traditional Framingham risk factors, evidences suggest that nontraditional risk factors, such as inflammation, oxidative stress, endothelial dysfunction, and vascular calcification also contribute to this extremely high risk of CVD. Disturbance in the mineral metabolism, especially in the ions of Ca and PO4, are linked to enhanced calcification of blood vessels. Although the mechanism(s) of this enhanced calcification process are not fully understood, current knowledge suggests that a large number (and an imbalance between them) of circulating promoters and inhibitors of the calcification process, that is, fetuin-A (or alpha 2-Heremans-Schmid glycoprotein, AHSG), matrix-Gla protein (MGP), osteoprotegerin (OPG), osteopontin (OPN), bone morphogenetic proteins (BMPs), and inorganic pyrophosphate (PPi), are involved in the deterioration of vascular tissue. Thus, an imbalance in these factors may contribute to the high prevalence of vascular complications in CKD patients. Among these mediators, studies on fetuin-A deserve further attention as clinical studies consistently show that fetuin-A deficiency is associated with vascular calcification, all-cause and cardiovascular mortality in CKD patients. Both chronic inflammation and the uremic milieu per se may contribute to fetuin-A depletion, as well as specific mutations in the AHSG gene. Recent experimental and clinical studies also suggest an intriguing link between fetuin-A, insulin resistance, and the metabolic syndrome.
C1 [Suliman, Mohamed E.] Karolinska Univ, Huddinge Hosp, Dept Clin Sci Intervent & Technol, Div Renal Med, S-14186 Huddinge, Sweden.
   Karolinska Univ, Huddinge Hosp, Div Baxter Novum, Karolinska Inst, S-14186 Huddinge, Sweden.
C3 Karolinska Institutet; Karolinska University Hospital; Karolinska
   Institutet; Karolinska University Hospital
RP Suliman, ME (corresponding author), Karolinska Univ, Huddinge Hosp, Dept Clin Sci Intervent & Technol, Div Renal Med, S-14186 Huddinge, Sweden.
RI Lindholm, Bengt/P-1334-2017
OI Lindholm, Bengt/0000-0003-4269-4293; Stenvinkel,
   Peter/0000-0002-8785-4820
FU Swedish Heart and Lung foundation; Swedish Medical Research Council;
   Martin Rinds Foundation
FX This work was supported by Swedish Heart and Lung foundation (P.S.),
   Swedish Medical Research Council (P.S.), and Martin Rinds Foundation
   (P.S.).
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NR 244
TC 31
Z9 33
U1 1
U2 13
PU ELSEVIER ACADEMIC PRESS INC
PI SAN DIEGO
PA 525 B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0065-2423
BN 978-0-12-374209-4
J9 ADV CLIN CHEM
JI Advan. Clin. Chem.
PY 2008
VL 46
BP 217
EP 262
DI 10.1016/S0065-2423(08)00406-X
PG 46
WC Medical Laboratory Technology
WE Book Citation Index – Science (BKCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA BIM47
UT WOS:000260841700006
PM 19004191
DA 2025-06-11
ER

PT J
AU Craiem, D
   Chironi, G
   Gariepy, J
   Miranda-Lacet, J
   Levenson, J
   Simon, A
AF Craiem, Damian
   Chironi, Gilles
   Gariepy, Jerome
   Miranda-Lacet, Jennifer
   Levenson, Jaime
   Simon, Alain
TI New monitoring software for larger clinical application of brachial
   artery flow-mediated vasodilatation measurements
SO JOURNAL OF HYPERTENSION
LA English
DT Article
DE brachial artery; endothelium; ultrasound; vasodilatation
ID SHEAR-STRESS; DILATATION; DILATION; VARIABILITY; RESPONSES; DIAMETER;
   GENDER
AB Background The reproducibility of brachial artery flow-mediated vasodilatation (FMD) is limited by the operator dependence of most measurement methods.
   Methods A new automated computerized analysis of brachial artery ultrasound scan providing a continuous evolution of the diameter during acute hyperemia, reactive to short hyperemia of the foream and hand, was tested in 10 normal volunteers and 26 asymptomatic patients with cardiovascular risk factors such as hypertension, hypercholesterolemia, heavy smoking, history of premature coronary heart disease and the metabolic syndrome. FMD was the percentage of the maximum hyperemic diastolic diameter from baseline. Within-reading variations in FMD and diameters were assessed by reading one scan from the same subject twice by two observers. The within-subject variability of FMD was assessed by analysing two repeated measurements in the same subject by the same operator 1 h, 1 week or 1 month apart.
   Results Coefficients of variation (CV) of repeated FMD readings were 7.5% in normal volunteers and 6.9% in patients with risk factors. CV of repeated FMD measurements 1 h apart were 7.8% in normal volunteers and 16.5% in patients with risk factors. In normal volunteers, CV of repeated FMD measurements 1 week apart was 9.6%, and in patients with risk factors CV of repeated FMD measurement 1 month apart was 18.1%.
   Conclusion This method overcomes the variability of FMD measurement seen with conventional manual analysis in normal volunteers, and to a lesser extent in patients with major cardiovascular risk factors, thus supporting its clinical applicability to patients with disease conditions.
C1 Univ Favaloro, Fac Ciencias Exactas & Nat, Buenos Aires, DF, Argentina.
   Univ Paris 05, AP HP, Hop Europeen Georges Pompidou, Ctr Med Prevent Cardiovasc,Fac Med, Paris, France.
C3 Assistance Publique Hopitaux Paris (APHP); Universite Paris Cite;
   Hopital Universitaire Europeen Georges-Pompidou - APHP
RP Simon, A (corresponding author), Hop Broussais, Ctr Med Prevent Cardiovasc, 96 Rue Didot, F-75674 Paris, France.
EM alain.simon@brs.ap-hop-paris.fr
RI Craiem, Damian/AAN-1069-2021
OI Craiem, Damian/0000-0003-1065-799X
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NR 21
TC 27
Z9 31
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0263-6352
EI 1473-5598
J9 J HYPERTENS
JI J. Hypertens.
PD JAN
PY 2007
VL 25
IS 1
BP 133
EP 140
DI 10.1097/HJH.0b013e3280109287
PG 8
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 126PB
UT WOS:000243525700020
PM 17143184
DA 2025-06-11
ER

PT J
AU Ahmadi, P
   Doyle, D
   Mojarad, N
   Taherkhani, S
   Janzadeh, A
   Honardoost, M
   Gholami, M
AF Ahmadi, Parisa
   Doyle, David
   Mojarad, Negin
   Taherkhani, Soroush
   Janzadeh, Atousa
   Honardoost, Maryam
   Gholami, Mitra
TI Effects of micro- and nanoplastic exposure on macrophages: a review of
   molecular and cellular mechanisms
SO TOXICOLOGY MECHANISMS AND METHODS
LA English
DT Review; Early Access
DE Macrophage; microplastic; nanoplastic; phagocytosis; inflammation;
   trained immunity; SLE; RA; Autoimmunity; metabolic syndrome
ID NLRP3 INFLAMMASOME; APOPTOTIC CELL; MICROPLASTICS; NANOPARTICLES;
   ACTIVATION; PHAGOCYTOSIS; DEGRADATION; AGGREGATION; METABOLISM;
   POLYESTER
AB Micro- and nanoplastics (MNPs), pervasive environmental pollutants, contaminate water, soil, air, and the food chain and ultimately accumulate in living organisms. Macrophages are the main immune cells that gather around MNPs and engulf them through the process of phagocytosis. This internalization triggers M1 polarization and the secretion of inflammatory cytokines, including IL-1, IL-18, IL-12, TNF-alpha, and IFN-gamma. Furthermore, MNPs damage mitochondria and lysosomes, causing overactivation of iNOS and excessive production of ROS. This results in cellular stress and induce apoptosis, necroptosis, and, in some cases, metosis in macrophages. The internalization of MNPs also increases the expression of receptors, involving CD36, SR-A, LOX-1, and the macrophage receptor with a collagenous structure (MARCO) while decreasing ABCA-1 and ABCG-1. MNPs in adipose tissue macrophages trigger proinflammatory cytokine secretion, causing adipogenesis, lipid accumulation, insulin resistance, and the secretion of inflammatory cytokines in adipocytes. Various factors influence the rate of MNP internalization by macrophages, including size, charge, and concentration, which affect internalization through passive diffusion. Receptor-mediated phagocytosis of MNPs occurs directly via receptors like T-cell immunoglobulin and mucin domain containing 4 (TIM-4) and MARCO. The attachment of biomolecules, including proteins, antibodies, opsonins, or microbes to MNPs (forming corona structures) promotes indirect receptor-mediated endocytosis, as macrophages possess receptors like TLRs and Fc gamma RIII. MNPs also cause gut dysbiosis, a risk factor for proinflammatory microenvironment and M1 polarization. Here, we review the mechanisms and consequences of MNP macrophage exposure, which is linked to autoimmunity, inflammation, and cardiometabolic syndrome manifestations, including atherosclerosis and obesity, highlighting the immunotoxicity of MNPs.
C1 [Ahmadi, Parisa] Mashhad Univ Med Sci, Immunol Res Ctr, Mashhad, Iran.
   [Ahmadi, Parisa; Janzadeh, Atousa] Iran Univ Med Sci, Neuromusculoskeletal Res Ctr, Tehran, Iran.
   [Doyle, David; Mojarad, Negin] Cent Michigan Univ, Program Neurosci, Mt Pleasant, MI USA.
   [Doyle, David] Cent Michigan Univ, Coll Med, Mt Pleasant, MI USA.
   [Taherkhani, Soroush] Iran Univ Med Sci, Sch Med, Dept Physiol, Tehran, Iran.
   [Honardoost, Maryam] Iran Univ Med Sci, Breast Hlth & Canc Res Ctr, Tehran, Iran.
   [Gholami, Mitra] Iran Univ Med Sci, Res Ctr Environm Hlth Technol, Tehran, Iran.
   [Gholami, Mitra] Iran Univ Med Sci, Sch Publ Hlth, Dept Environm Hlth Engn, Tehran, Iran.
C3 Mashhad University of Medical Sciences; Iran University of Medical
   Sciences; Central Michigan University; Central Michigan University; Iran
   University of Medical Sciences; Iran University of Medical Sciences;
   Iran University of Medical Sciences; Iran University of Medical Sciences
RP Janzadeh, A (corresponding author), Iran Univ Med Sci, Neuromusculoskeletal Res Ctr, Tehran, Iran.; Honardoost, M (corresponding author), Iran Univ Med Sci, Breast Hlth & Canc Res Ctr, Tehran, Iran.; Gholami, M (corresponding author), Iran Univ Med Sci, Sch Publ Hlth, Dept Environm Hlth Engn, Tehran, Iran.
EM Janzadeh.at@iums.ac.ir; Honardoost.m@iums.ac.ir; gholamim@iums.ac.ir
RI ahmadi, parisa/LNR-0153-2024; Gholami, Mitra/F-9490-2014
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NR 202
TC 0
Z9 0
U1 4
U2 4
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1537-6516
EI 1537-6524
J9 TOXICOL MECH METHOD
JI Toxicol. Mech. Methods
PD 2025 MAY 20
PY 2025
DI 10.1080/15376516.2025.2500546
EA MAY 2025
PG 24
WC Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Toxicology
GA 2VL6N
UT WOS:001492273600001
PM 40323219
DA 2025-06-11
ER

PT J
AU Arghavani, H
   Bilodeau, JF
   Rudkowska, I
AF Arghavani, Hana
   Bilodeau, Jean-Francois
   Rudkowska, Iwona
TI Association Between Circulating Fatty Acids and Blood Pressure: A Review
SO CURRENT NUTRITION REPORTS
LA English
DT Review
DE Blood pressure; Circulating fatty acids; Cardiovascular disease; Dietary
   recommendations
ID CARDIOVASCULAR RISK-FACTORS; ARTERIAL STIFFNESS; METABOLIC SYNDROME;
   PLASMA-LEVELS; OMEGA-3; HYPERTENSION; VARIABILITY; REFLECTION; OBESITY;
   LEVEL
AB Purpose of ReviewHigh blood pressure (BP) or hypertension (HTN) remains key risk factors for cardiovascular disease (CVD). Circulating fatty acids (FAs) in the blood can affect directly cardiovascular hemodynamics and serves as building blocks for endocrine mediators modifying inflammatory processes and vascular function. This review aims to describe optimal circulating FA profiles for BP to adjust dietary recommendations for HTN prevention.Recent FindingsRecent research highlights the critical role of FAs in regulating inflammation and vascular function. Different FAs have varying effects on oxidative stress, insulin resistance, inflammation, and vascular dysfunction, all contributing to HTN. These findings emphasize the importance of FAs in managing BP and preventing CVD.SummaryUp-to-now, findings suggest that eicosapentaenoic acid (20:5n3), docosahexaenoic acid (22:6n3), arachidic acid (20:0), behenic acid (22:0) and lignoceric acid (24:0) were promising candidates in reducing BP and thus, dietary intake could be recommended. Conversely, dietary intake of myristic acid (14:0), palmitic acid (16:0), and industrial trans FAs (iTFAs) should be restricted due to their association with elevated BP. Further research is warranted for pentadecanoic acid (15:0), heptadecanoic acid (17:0), stearic acid (18:0), alpha-linolenic acid (18:3n3), docosapentaenoic acid (22:5n3), linoleic acid (18:2n6), dihomo-gamma-linolenic acid (20:3n6), arachidonic acid (20:4n6), palmitoleic acid (16:1n7), and ruminant TFAs since their associations with BP present inconsistencies in the literature. Lifestyle factors such as dietary intake, physical activity, alcohol consumption and smoking should be considered when examining the relationship between FAs and BP. Overall, the FAs profile may contribute to BP level management; therefore, dietary recommendations are important.
C1 [Arghavani, Hana; Bilodeau, Jean-Francois; Rudkowska, Iwona] Laval Univ, CHU Quebec, Res Ctr, Endocrinol & Nephrol Axis,CHUL, 2705 Blvd Laurier, Quebec City, PQ G1V 4G2, Canada.
   [Bilodeau, Jean-Francois] Laval Univ, Fac Med, Dept Med, Quebec City, PQ G1V 0A6, Canada.
   [Rudkowska, Iwona] Laval Univ, Fac Med, Dept Kinesiol, Quebec City, PQ G1V 0A6, Canada.
C3 Laval University; Laval University Hospital; Laval University; Laval
   University
RP Rudkowska, I (corresponding author), Laval Univ, CHU Quebec, Res Ctr, Endocrinol & Nephrol Axis,CHUL, 2705 Blvd Laurier, Quebec City, PQ G1V 4G2, Canada.; Rudkowska, I (corresponding author), Laval Univ, Fac Med, Dept Kinesiol, Quebec City, PQ G1V 0A6, Canada.
EM Iwona.rudkowska@crchudequebec.ulaval.ca
RI Bilodeau, Jean-François/B-1712-2013
FU Fonds de recherche du Quebec - Nature et technologies (FRQ-NT)
FX HA received the Fonds de recherche du Quebec - Nature et technologies
   (FRQ-NT).
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NR 105
TC 1
Z9 1
U1 5
U2 5
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
EI 2161-3311
J9 CURR NUTR REP
JI Curr. Nutr. Rep.
PD JAN 8
PY 2025
VL 14
IS 1
AR 15
DI 10.1007/s13668-024-00602-3
PG 17
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA R5V6F
UT WOS:001392126200001
PM 39775363
DA 2025-06-11
ER

PT J
AU Angelini, G
   Russo, S
   Mingrone, G
AF Angelini, Giulia
   Russo, Sara
   Mingrone, Geltrude
TI Intestinal heat shock proteins in metabolic syndrome: Novel mediators of
   obesity and its comorbidities resolution after metabolic surgery
SO CELL STRESS & CHAPERONES
LA English
DT Article
DE Heat shock proteins; GRP78; Obesity; Metabolic surgery
ID Y GASTRIC BYPASS; GAMMA TARGET GENES; INSULIN-RESISTANCE;
   ENDOPLASMIC-RETICULUM; SLEEVE GASTRECTOMY; SINGLE-CENTER; OPEN-LABEL;
   FOLLOW-UP; GRP78; STRESS
AB Over the past 40 years, the prevalence of obesity has risen dramatically, reaching epidemic proportions. Metabolic surgery has proven to be highly effective in treating obesity, leading to significant improvements or complete resolution of obesity -related comorbidities. Research conducted in both animals and humans suggests that the metabolic benefits achieved through metabolic surgery cannot be solely attributed to weight loss. Indeed, there has been an increasing recognition of intestinal inflammation as a novel factor influencing obesity. The gastrointestinal tract is continuously exposed to dietary components, particularly diets rich in saturated fats, which are known to contribute to obesity. It is now widely accepted that heat shock proteins can be released from various cells including intestinal epithelial cells and act as proinflammatory signals. Several studies have shown that circulating levels of glucose -regulated protein 78 (GRP78) are increased in subjects with obesity and correlate with the severity of the disease. Moreover, mice with a partial knockout of GRP78 are protected from diet -induced obesity. In this review, we discuss the role of GRP78 in the development of obesity. Several evidence suggests that GRP78 can influence adipogenesis, lipid droplets stabilization, insulin resistance, and liver steatosis. We also provide an update on GRP78 regulation following metabolic surgery, focusing on the bypass of the small intestine as a key factor for GRP78 secretion. Finally, we discuss the potential role of monoclonal antibodies against GRP78 as a treatment for obesity.
C1 [Angelini, Giulia; Russo, Sara; Mingrone, Geltrude] Univ Cattolica Sacro Cuore, Dept Translat Med & Surg, Rome, Italy.
   [Mingrone, Geltrude] Fdn Policlin Univ A Gemelli IRCCS, Dept Med & Surg Sci, Rome, Italy.
   [Mingrone, Geltrude] Kings Coll Hosp London, Sch Cardiovasc & Metab Med & Sci, Div Diabet & Nutr Sci, London, England.
C3 Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli;
   Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli;
   King's College Hospital NHS Foundation Trust; King's College Hospital
RP Angelini, G (corresponding author), Univ Cattolica Sacro Cuore, Dept Translat Med & Surg, Rome, Italy.
EM giulia.angelini@unicatt.it
RI ANGELINI, GIULIA/AFV-8447-2022; Russo, Sara/KHX-7474-2024
OI ANGELINI, GIULIA/0000-0001-6753-745X
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NR 65
TC 1
Z9 1
U1 1
U2 2
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1355-8145
EI 1466-1268
J9 CELL STRESS CHAPERON
JI Cell Stress Chaperones
PD APR
PY 2024
VL 29
IS 2
BP 217
EP 226
DI 10.1016/j.cstres.2024.02.003
EA MAR 2024
PG 10
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA RC6W3
UT WOS:001225521300001
PM 38412940
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Olas, B
AF Olas, Beata
TI An Overview of the Versatility of the Parts of the Globe Artichoke
   (Cynara scolymus L.), Its By-Products and Dietary Supplements
SO NUTRIENTS
LA English
DT Review
DE artichoke; C. scolymus; Cynara scolymus L.; cynara
ID LEAF EXTRACT SUPPLEMENTATION; INDUCED OXIDATIVE STRESS; DOUBLE-BLIND;
   METABOLIC SYNDROME; PROTECTIVE PROPERTIES; CHOLESTEROL; EFFICACY;
   LEAVES; HEADS; TCF7L2-RS7903146
AB Cynara scolymus, also known as the globe artichoke or artichoke, is grown as a food, mainly in the Mediterranean, Canary Islands, and Egypt, as well as in Asia and South America. It has also been associated with various health benefits and is used in plant-based dietary supplements and herbal infusions. Its edible parts, consisting of the head or capitula, flower, and leaves, have shown various biological activities, including anti-cancer, hepatoprotective and antimicrobial potential. The leaves are mainly used in infusions and extracts for their health-promoting properties, although all their edible parts may also be consumed as fresh, frozen, or canned foods. However, its primary health-promoting activity is associated with its antioxidant potential, which has been linked to its chemical composition, particularly its phenolic compounds (representing 96 mg of gallic acid equivalent per 100 g of raw plant material) and dietary fiber. The main phenolic compounds in the heads and leaves are caffeic acid derivatives, while the flavonoids luteolin and apigenin (both present as glucosides and rutinosides) have also been identified. In addition, heat-treated artichokes (i.e., boiled, steamed or fried), their extracts, and waste from artichoke processing also have antioxidant activity. The present paper reviews the current literature concerning the biological properties of different parts of C. scolymus, its by-products and dietary supplements, as well as their chemical content and toxicity. The literature was obtained by a search of PubMed/Medline, Google Scholar, Web of Knowledge, ScienceDirect, and Scopus, with extra papers being identified by manually reviewing the references.
C1 [Olas, Beata] Univ Lodz, Fac Biol & Environm Protect, Dept Gen Biochem, Pomorska 141 143, PL-90236 Lodz, Poland.
C3 University of Lodz
RP Olas, B (corresponding author), Univ Lodz, Fac Biol & Environm Protect, Dept Gen Biochem, Pomorska 141 143, PL-90236 Lodz, Poland.
EM beata.olas@biol.uni.lodz.pl
OI Olas, Beata/0000-0002-7048-2952
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NR 117
TC 8
Z9 9
U1 8
U2 18
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD MAR
PY 2024
VL 16
IS 5
AR 599
DI 10.3390/nu16050599
PG 18
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA KY0G6
UT WOS:001183403300001
PM 38474726
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Santos, LZAD
   de Menezes-Júnior, LAA
   de Freitas, SN
   Pimenta, FAP
   Machado-Coelho, GLL
   de Oliveira, FLP
   Neto, RMD
   Turbino-Ribeiro, SML
AF Santos, Luisa Zadra Armond de Almeida
   de Menezes-Junior, Luiz Antonio Alves
   de Freitas, Silvia Nascimento
   Pimenta, Fausto Aloisio Pedrosa
   Machado-Coelho, George Luiz Lins
   de Oliveira, Fernando Luiz Pereira
   do Nascimento Neto, Raimundo Marques
   Turbino-Ribeiro, Silvana Mara Luz
TI Vitamin D deficiency and hyperglycemia in male rotating shift workers: A
   disturbed circadian rhythms influence
SO CLINICAL NUTRITION ESPEN
LA English
DT Article
DE Shift work; Hypovitaminosis D; Hyperglycemia; Circadian rhythm;
   Occupational health
ID METABOLIC SYNDROME; SOCIETY; PREVALENCE; RECEPTOR; DISEASE; STRESS
AB Background: Shift work is related to several negative impacts on the health of workers. This study aimed to evaluate the association between vitamin D deficiency (VDD) and hyperglycemia in shift workers.Methodology: This cross-sectional study included male rotating shift workers in an iron ore extraction company. Participants were classified as VDD when 25(OH)D < 20 ng/mL for a healthy population and 25(OH)D < 30 ng/mL for groups at risk for VDD. Hyperglycemia was classified when fasting glucose & GE;100 mg/dL or HbA1c & GE; 5.7%. Data were compared using chi-square analysis with Cramer's V as effect size, and Bonferroni correction. Multivariate logistic regression, from a model of determination, was performed to investigate whether VDD was associated with hyperglycemia. Results: The study evaluated 1411 workers, most workers were aged 30-39 years (53.2%), and 77.5% selfdeclared as black, brown, with up to complete high school (71.4%) and working alternate shifts for more than 5 years (76.1%). Regarding glucose and vitamin D, 32.0% and 29.1% of the workers had hyperglycemia and VDD, respectively. In multivariate analysis, controlled for confounding factors, workers with VDD had a 119% increased chance of hyperglycemia (OR: 2.19; IC95%: 1.56-3.08). Furthermore, vitamin D levels in distribution quintiles showed a dose-response gradient in relation to hyperglycemia, where increased vitamin D values were associated with a reduction in the occurrence of hyperglycemia.Conclusion: Rotating shift workers with vitamin D deficiency are more likely to have hyperglycemia.& COPY; 2023 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights reserved.
C1 [Santos, Luisa Zadra Armond de Almeida; de Menezes-Junior, Luiz Antonio Alves; de Freitas, Silvia Nascimento; Turbino-Ribeiro, Silvana Mara Luz] Univ Fed Ouro Preto, Sch Nutr, Ouro Preto, MG, Brazil.
   [de Menezes-Junior, Luiz Antonio Alves; de Freitas, Silvia Nascimento; Machado-Coelho, George Luiz Lins] Univ Fed Ouro Preto, Nutr Sch, Postgrad Program Hlth & Nutr, Ouro Preto, MG, Brazil.
   [Pimenta, Fausto Aloisio Pedrosa; Machado-Coelho, George Luiz Lins; do Nascimento Neto, Raimundo Marques] Univ Fed Minas Gerais, Med Sch, Ouro Preto, MG, Brazil.
   [de Oliveira, Fernando Luiz Pereira] Univ Fed Ouro Preto, Stat Dept, Ouro Preto, MG, Brazil.
   [de Menezes-Junior, Luiz Antonio Alves] Univ Fed Ouro Preto, R Diogo Vasconcelos 122, Ouro Preto, MG, Brazil.
C3 Universidade Federal de Ouro Preto; Universidade Federal de Ouro Preto;
   Universidade Federal de Minas Gerais; Universidade Federal de Ouro
   Preto; Universidade Federal de Ouro Preto
RP de Menezes-Júnior, LAA (corresponding author), Univ Fed Ouro Preto, R Diogo Vasconcelos 122, Ouro Preto, MG, Brazil.
EM luiz.menezes@ufop.edu.br
RI Menezes Júnior, Luiz/IAN-2636-2023; Machado-Coelho, George
   Luiz/ABA-4312-2021; Pimenta, Fausto/W-3142-2019; Pereira de Oliveira,
   Fernando Luiz/P-6895-2019; Pereira de Oliveira, Fernando
   Luiz/I-5586-2014
OI Nascimento de Freitas, Silvia/0000-0002-4119-0352; Ribeiro, Silvana
   Mara/0000-0002-3645-3699; Menezes-Junior, Luiz/0000-0002-4497-5358;
   Pereira de Oliveira, Fernando Luiz/0000-0001-6513-3339
FU Brazilian Council for Scientific and Technological Development (CNPq,
   Distrito Federal, Brazil); Coordination for the Improvement of Higher
   Education Personnel-Brazil (CAPES) [001]
FX This study was supported by the Brazilian Council for Scientific and
   Technological Development (CNPq, Distrito Federal, Brazil) and
   Coordination for the Improvement of Higher Education Personnel-Brazil
   (CAPES); finance code 001 for Ph.D. student scholarship.
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NR 52
TC 4
Z9 4
U1 0
U2 3
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2405-4577
J9 CLIN NUTR ESPEN
JI Clin. Nutr. ESPEN
PD OCT
PY 2023
VL 57
BP 258
EP 265
DI 10.1016/j.clnesp.2023.06.031
EA JUL 2023
PG 8
WC Nutrition & Dietetics
WE Emerging Sources Citation Index (ESCI)
SC Nutrition & Dietetics
GA O8ZG3
UT WOS:001046640500001
PM 37739666
DA 2025-06-11
ER

PT J
AU Thiele, M
   Suvitaival, T
   Trost, K
   Kim, M
   de Zawadzki, A
   Kjaergaard, M
   Rasmussen, DN
   Lindvig, KP
   Israelsen, M
   Detlefsen, S
   Andersen, P
   Juel, HB
   Nielsen, T
   Georgiou, S
   Filippa, V
   Kuhn, M
   Nishijima, S
   Moitinho-Silva, L
   Rossing, P
   Trebicka, J
   Anastasiadou, E
   Bork, P
   Hansen, T
   Legido-Quigley, C
   Krag, A
AF Thiele, Maja
   Suvitaival, Tommi
   Trost, Kajetan
   Kim, Min
   de Zawadzki, Andressa
   Kjaergaard, Maria
   Rasmussen, Ditlev Nytoft
   Lindvig, Katrine Prier
   Israelsen, Mads
   Detlefsen, Sonke
   Andersen, Peter
   Juel, Helene Baek
   Nielsen, Trine
   Georgiou, Stella
   Filippa, Vicky
   Kuhn, Michael
   Nishijima, Suguru
   Moitinho-Silva, Lucas
   Rossing, Peter
   Trebicka, Jonel
   Anastasiadou, Ema
   Bork, Peer
   Hansen, Torben
   Legido-Quigley, Cristina
   Krag, Aleksander
CA MicrobLiver Consortium
TI Sphingolipids Are Depleted in Alcohol-Related Liver Fibrosis
SO GASTROENTEROLOGY
LA English
DT Article
DE Fatty Liver; Fibrosis; Metabolomics; Alcoholic Liver Disease
ID INSULIN-RESISTANCE; FATTY-ACIDS; LIPIDOMICS; DISEASE; STEATOHEPATITIS;
   METABOLISM; BIOMARKERS; CERAMIDE; STRESS; LIPIDS
AB BACKGROUND & AIMS: Alcohol disturbs hepatic lipid syn-thesis and transport, but the role of lipid dysfunction in alcohol -related liver disease (ALD) is unclear. In this biopsy-controlled, prospective, observational study, we characterized the liver and plasma lipidomes in patients with early ALD. METHODS: We performed mass spectrometry-based lipidomics of paired liver and plasma samples from 315 patients with ALD and of plasma from 51 matched healthy controls. We associated lipid levels with histologic fibrosis, inflammation, and steatosis with correction for multiple testing and adjustment for confounders. We further investigated sphingolipid regulation by means of quantitative real-time polymerase chain reaction sequencing of microRNA, prediction of liver-related events, and tested cau-sality with Mendelian randomization. RESULTS: We detected 198 lipids in the liver and 236 lipids in the circulation from 18 lipid classes. Most sphingolipids (sphingomyelins and ceram-ides) and phosphocholines were co-down-regulated in both liver and plasma, where lower abundance correlated with higher fibrosis stage. Sphingomyelins showed the most pro-nounced negative correlation to fibrosis, mirrored by negative correlations in both liver and plasma with hepatic inflamma-tion. Reduced sphingomyelins predicted future liver-related events. This seemed to be characteristic of "pure ALD," as sphingomyelin levels were higher in patients with concomitant metabolic syndrome and ALD/nonalcoholic fatty liver disease overlap. Mendelian randomization in FinnGen and UK Biobanks indicated ALD as the cause of low sphingomyelins, and alcohol use disorder did not correlate with genetic susceptibility to low sphingomyelin levels. CONCLUSIONS: Alcohol-related liver fibrosis is characterized by selective and progressive lipid depletion in liver and blood, particularly sphingomyelins, which also associates with progression to liver-related events.
C1 [Thiele, Maja; Kjaergaard, Maria; Rasmussen, Ditlev Nytoft; Lindvig, Katrine Prier; Israelsen, Mads; Andersen, Peter; Krag, Aleksander] Odense Univ Hosp, Ctr Liver Res, Dept Gastroenterol & Hepatol, Odense, Denmark.
   [Thiele, Maja; Kjaergaard, Maria; Lindvig, Katrine Prier; Detlefsen, Sonke; Krag, Aleksander] Univ Southern Denmark, Fac Hlth Sci, Dept Clin Res, Odense, Denmark.
   [Suvitaival, Tommi; Trost, Kajetan; Kim, Min; de Zawadzki, Andressa; Rossing, Peter; Legido-Quigley, Cristina] Steno Diabet Ctr Copenhagen, Herlev, Denmark.
   [Trost, Kajetan; Juel, Helene Baek; Nielsen, Trine] Univ Copenhagen, Novo Nord Fdn Ctr Basic Metab Res, Copenhagen, Denmark.
   [Detlefsen, Sonke; Hansen, Torben] Odense Univ Hosp, Dept Pathol, Odense, Denmark.
   [Georgiou, Stella; Filippa, Vicky; Anastasiadou, Ema] Acad Athens, Biomed Res Fdn, Dept Genet, Athens, Greece.
   [Kuhn, Michael; Nishijima, Suguru; Moitinho-Silva, Lucas; Bork, Peer] European Mol Biol Lab, Heidelberg, Germany.
   [Trebicka, Jonel] Munster Univ, Univ Klinikum Munster, Med Klin B, Munster, Germany.
   [Trebicka, Jonel] European Fdn Study Chron Liver Failure, Barcelona, Spain.
   [Legido-Quigley, Cristina] Kings Coll London, Inst Pharmaceut Sci, Sch Life Sci & Med, London, England.
C3 University of Southern Denmark; Odense University Hospital; University
   of Southern Denmark; Steno Diabetes Center; University of Copenhagen;
   University of Southern Denmark; Odense University Hospital; Academy of
   Athens; European Molecular Biology Laboratory (EMBL); University of
   Munster; University of London; King's College London
RP Legido-Quigley, C (corresponding author), Steno Diabet Ctr Copenhagen, Borgmester Ib Juuls Vej 83, DK-2730 Herlev, Denmark.; Krag, A (corresponding author), Odense Univ Hosp, Ctr Liver Res, Dept Gastroenterol & Hepatol, JB Winslows Vej 4, DK-5000 Odense, Denmark.
EM cristina.legido.quigley@regionh.dk; Aleksander.Krag@rsyd.dk
RI Suvitaival, Tommi/AAZ-3518-2020; Juel, Helene/AAD-2843-2020; Krag,
   Aleksander/ABH-9649-2020; Andersen, Paal/H-2087-2015; Hansen,
   Torben/J-8065-2012; Nielsen, Trine/HJZ-4867-2023; de Zawadzki,
   Andressa/AAM-5622-2020; rossing, peter/AAH-7879-2021; Arumugam,
   Manimozhiyan/E-1211-2011; Nishijima, Suguru/M-2933-2018; Thiele,
   Maja/AAD-2353-2019
OI Suvitaival, Tommi/0000-0002-2583-4912; Arumugam,
   Manimozhiyan/0000-0002-0886-9101; Juel, Helene B/0000-0002-5763-8545;
   Legido-Quigley, Cristina/0000-0002-4018-214X; Lindvig, Katrine
   Prier/0000-0001-7891-7706; Andersen, Peter/0009-0001-4278-3731; Krag,
   Aleksander/0000-0002-9598-4932; Trost, Kajetan/0000-0002-3863-5269;
   Nishijima, Suguru/0000-0002-8444-9272; Trebicka,
   Jonel/0000-0002-7028-3881; Kjaergaard, Maria/0000-0001-8452-1820;
   Nielsen, Trine/0000-0002-2066-7895; rossing, peter/0000-0002-1531-4294;
   Thiele, Maja/0000-0003-1854-1924; Kim, Min/0000-0002-8769-4804
FU European Union [668031]; Novo Nordisk Foundation [NNF15OC0016692,
   NNF20OC0059393]
FX This project received funding from the European Union's Horizon 2020
   research and innovation program under grant agreement 668031 to the
   GALAXY Consortium, and from the Challenge grant NNF15OC0016692 from the
   Novo Nordisk Foundation to the MicrobLiver Consortium. Maja Thiele is
   funded by a grant from the Novo Nordisk Foundation (NNF20OC0059393).
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NR 56
TC 22
Z9 22
U1 3
U2 21
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0016-5085
EI 1528-0012
J9 GASTROENTEROLOGY
JI Gastroenterology
PD JUN
PY 2023
VL 164
IS 7
BP 1248
EP 1260
DI 10.1053/j.gastro.2023.02.023
EA MAY 2023
PG 13
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA J9QG8
UT WOS:001012893700001
PM 36849086
OA Green Published
DA 2025-06-11
ER

PT J
AU Menon, NJ
   Halvorson, BD
   Alimorad, GH
   Frisbee, JC
   Lizotte, DJ
   Ward, AD
   Goldman, D
   Chantler, PD
   Frisbee, SJ
AF Menon, Nithin J.
   Halvorson, Brayden D.
   Alimorad, Gabrielle H.
   Frisbee, Jefferson C.
   Lizotte, Daniel J.
   Ward, Aaron D.
   Goldman, Daniel
   Chantler, Paul D.
   Frisbee, Stephanie J.
TI A novel vascular health index: Using data analytics and population
   health to facilitate mechanistic modeling of microvascular status
SO FRONTIERS IN PHYSIOLOGY
LA English
DT Article
DE microcirculation; vascular biology; metabolic disease; novel metrics;
   vascular health and disease
ID SKELETAL-MUSCLE; RESISTANCE ARTERIES; METABOLIC SYNDROME;
   ADIPOSE-TISSUE; HYPERTENSION; RAREFACTION; MICROCIRCULATION; PERFUSION;
   STRESS
AB The study of vascular function across conditions has been an intensive area of investigation for many years. While these efforts have revealed many factors contributing to vascular health, challenges remain for integrating results across research groups, animal models, and experimental conditions to understand integrated vascular function. As such, the insights attained in clinical/population research from linking datasets, have not been fully realized in the basic sciences, thus frustrating advanced analytics and complex modeling. To achieve comparable advances, we must address the conceptual challenge of defining/measuring integrated vascular function and the technical challenge of combining data across conditions, models, and groups. Here, we describe an approach to establish and validate a composite metric of vascular function by comparing parameters of vascular function in metabolic disease (the obese Zucker rat) to the same parameters in age-matched, "healthy " conditions, resulting in a common outcome measure which we term the vascular health index (VHI). VHI allows for the integration of datasets, thus expanding sample size and permitting advanced modeling to gain insight into the development of peripheral and cerebral vascular dysfunction. Markers of vascular reactivity, vascular wall mechanics, and microvascular network density are integrated in the VHI. We provide a detailed presentation of the development of the VHI and provide multiple measures to assess face, content, criterion, and discriminant validity of the metric. Our results demonstrate how the VHI captures multiple indices of dysfunction in the skeletal muscle and cerebral vasculature with metabolic disease and provide context for an integrated understanding of vascular health under challenged conditions.
C1 [Menon, Nithin J.; Halvorson, Brayden D.; Frisbee, Jefferson C.; Ward, Aaron D.; Goldman, Daniel] Univ Western Ontario, Schulich Sch Med & Dent, Dept Med Biophys, London, ON, Canada.
   [Alimorad, Gabrielle H.; Lizotte, Daniel J.; Frisbee, Stephanie J.] Univ Western Ontario, Schulich Sch Med & Dent, Dept Epidemiol & Biostat, London, ON, Canada.
   [Lizotte, Daniel J.] Univ Western Ontario, Fac Sci, Dept Comp Sci, London, ON, Canada.
   [Lizotte, Daniel J.; Ward, Aaron D.; Frisbee, Stephanie J.] Lawson Hlth Res Inst, London, ON, Canada.
   [Chantler, Paul D.] West Virginia Univ, Sch Med, Dept Human Performance Exercise Physiol, Morgantown, WV USA.
   [Frisbee, Stephanie J.] Univ Western Ontario, Schulich Sch Med & Dent, Dept Pathol & Lab Med, London, ON, Canada.
C3 Western University (University of Western Ontario); Western University
   (University of Western Ontario); Western University (University of
   Western Ontario); Western University (University of Western Ontario);
   University Western Ontario Hospital; West Virginia University; Western
   University (University of Western Ontario)
RP Frisbee, SJ (corresponding author), Univ Western Ontario, Schulich Sch Med & Dent, Dept Epidemiol & Biostat, London, ON, Canada.; Frisbee, SJ (corresponding author), Lawson Hlth Res Inst, London, ON, Canada.; Frisbee, SJ (corresponding author), Univ Western Ontario, Schulich Sch Med & Dent, Dept Pathol & Lab Med, London, ON, Canada.
EM sfrisbee@uwo.ca
RI Goldman, Daniel/CAI-2887-2022; Ward, Aaron/B-4950-2015; Lizotte,
   Daniel/AAT-3170-2020; Halvorson, Brayden/IXN-1735-2023
OI Lizotte, Daniel/0000-0002-9258-8619; Goldman,
   Daniel/0000-0002-8707-5536; Ward, Aaron D/0009-0006-5064-9926; Frisbee,
   Stephanie/0000-0003-1526-1839; Frisbee, Jefferson/0000-0003-2751-0599
FU Ontario Graduate Scholarship; CIHR Doctoral Scholarship
FX Author NM is supported by an Ontario Graduate Scholarship and author BH
   is supported by a CIHR Doctoral Scholarship.
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NR 35
TC 1
Z9 2
U1 1
U2 1
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1664-042X
J9 FRONT PHYSIOL
JI Front. Physiol.
PD DEC 6
PY 2022
VL 13
AR 1071813
DI 10.3389/fphys.2022.1071813
PG 16
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA 7E1QO
UT WOS:000900952000001
PM 36561210
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Zhang, W
   Dong, XY
   Huang, R
AF Zhang, Wei
   Dong, Xiao Yu
   Huang, Rui
TI Gut Microbiota in Ischemic Stroke: Role of Gut Bacteria-Derived
   Metabolites
SO TRANSLATIONAL STROKE RESEARCH
LA English
DT Review
DE Ischemic stroke; Trimethylamine N-oxide; Short-chain fatty acids; Bile
   acids; Lipopolysaccharides; Phenylacetylglutamine
ID CHAIN FATTY-ACIDS; PITUITARY-ADRENAL AXIS; BLOOD-BRAIN-BARRIER;
   BILE-ACID; INTESTINAL MICROBIOTA; NEUROTROPHIC FACTOR; NEUROINFLAMMATION
   MODEL; CARDIOVASCULAR-DISEASE; COMMENSAL BACTERIA; NERVOUS-SYSTEM
AB Ischemic stroke (IS) remains a leading cause of death and long-term disability globally. Several mechanisms including glutamate excitotoxicity, calcium overload, neuroinflammation, oxidative stress, mitochondrial damage, and apoptosis are known to be involved in the pathogenesis of IS, but the underlying pathophysiology mechanisms of IS are not fully clarified. During the past decade, gut microbiota were recognized as a key regulator to affect the health of the host either directly or via their metabolites. Recent studies indicate that gut bacterial dysbiosis is closely related to hypertension, diabetes, obesity, dyslipidemia, and metabolic syndrome, which are the main risk factors for cardiovascular diseases. Increasing evidence indicates that IS can lead to perturbation in gut microbiota and increased permeability of the gut mucosa, known as "leaky gut," resulting in endotoxemia and bacterial translocation. In turn, gut dysbiosis and impaired intestinal permeability can alter gut bacterial metabolite signaling profile from the gut to the brain. Microbiota-derived products and metabolites, such as short-chain fatty acids (SCFAs), bile acids (BAs), trimethylamine N-oxide ( TMAO), lipopolysaccharides (LPS), and phenylacetylglutamine (PAGln) can exert beneficial or detrimental effects on various extraintestinal organs, including the brain, liver, and heart. These metabolites have been increasingly acknowledged as biomarkers and mediators of IS. However, the specific role of the gut bacterial metabolites in the context of stroke remains incompletely understood. In-depth studies on these products and metabolites may provide new insight for the development of novel therapeutics for IS.
C1 [Zhang, Wei; Dong, Xiao Yu; Huang, Rui] China Med Univ, Dept Neurol, Shengjing Hosp, Shenyang, Peoples R China.
C3 China Medical University
RP Huang, R (corresponding author), China Med Univ, Dept Neurol, Shengjing Hosp, Shenyang, Peoples R China.
EM huangr_cmu@163.com
OI Huang, Rui/0000-0002-4254-4685; Dong, Xiao Yu/0000-0003-3951-8037
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NR 195
TC 31
Z9 32
U1 2
U2 39
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1868-4483
EI 1868-601X
J9 TRANSL STROKE RES
JI Transl. Stroke Res.
PD DEC
PY 2023
VL 14
IS 6
BP 811
EP 828
DI 10.1007/s12975-022-01096-3
EA OCT 2022
PG 18
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA HC7H8
UT WOS:000871279800001
PM 36279071
DA 2025-06-11
ER

PT J
AU Borriello, M
   Lauria, F
   Sirangelo, I
   Aleksandrova, K
   Hebestreit, A
   Siani, A
   Russo, P
AF Borriello, Margherita
   Lauria, Fabio
   Sirangelo, Ivana
   Aleksandrova, Krasimira
   Hebestreit, Antje
   Siani, Alfonso
   Russo, Paola
TI Association between Urinary Advanced Glycation End Products and
   Subclinical Inflammation in Children and Adolescents: Results from the
   Italian I.Family Cohort
SO NUTRIENTS
LA English
DT Article
DE advanced glycation end products; urinary AGEs; inflammation; CRP;
   biomarkers; children; I; Family project
ID C-REACTIVE PROTEIN; FLUORESCENCE ASSAY; METABOLIC SYNDROME; RECEPTOR;
   RAGE; STRESS; BLOOD; ENDPRODUCTS; OVERWEIGHT; DISEASES
AB Advanced Glycation End Products (AGEs) have been positively correlated with inflammation in adults, while inconsistent evidence is available in children. We evaluated the association between urinary AGEs, measured by fluorescence spectroscopy, and biomarkers of subclinical inflammation in 676 healthy children/adolescents (age 11.8 +/- 1.6 years, M +/- SD) from the Italian cohort of the I.Family project. Urinary fluorescent AGEs were used as independent variable and high-sensitivity C-reactive protein (hs-CRP) was the primary outcome, while other biomarkers of inflammation were investigated as secondary outcomes. Participants with urinary AGEs above the median of the study population showed statistically significantly higher hs-CRP levels as compared to those below the median (hs-CRP 0.44 +/- 1.1 vs. 0.24 +/- 0.6 mg/dL, M +/- SD p = 0.002). We found significant positive correlations between urinary AGEs and hs-CRP (p = 0.0001), IL-15 (p = 0.001), IP-10 (p = 0.006), and IL-1Ra (p = 0.001). At multiple regression analysis, urinary AGEs, age, and BMI Z-score were independent variables predicting hs-CRP levels. We demonstrated for the first time, in a large cohort of children and adolescents, that the measurement of fluorescent urinary AGEs may represent a simple, noninvasive, and rapid technique to evaluate the association between AGEs and biomarkers of inflammation. Our data support a role of AGEs as biomarkers of subclinical inflammation in otherwise healthy children and adolescents.
C1 [Borriello, Margherita; Lauria, Fabio; Sirangelo, Ivana; Siani, Alfonso; Russo, Paola] CNR, Inst Food Sci, Via Roma 64, I-83100 Avellino, Italy.
   [Borriello, Margherita; Sirangelo, Ivana; Siani, Alfonso; Russo, Paola] Univ Campania Luigi Vanvitelli, Dept Precis Med, Sch Med & Surg, S Andrea Delle Dame Via L Crecchio 7, I-80138 Naples, Italy.
   [Aleksandrova, Krasimira; Hebestreit, Antje] Leibniz Inst Prevent Res & Epidemiol BIPS, Achterstr 30, D-28359 Bremen, Germany.
   [Aleksandrova, Krasimira] Univ Bremen, Fac Human & Hlth Sci, Grazerstr 2, D-28359 Bremen, Germany.
C3 Consiglio Nazionale delle Ricerche (CNR); Istituto di Scienze dell'
   Alimentazione (ISA-CNR); Universita della Campania Vanvitelli; Leibniz
   Association; Leibniz Institute for Prevention Research & Epidemiology
   (BIPS); University of Bremen
RP Siani, A (corresponding author), CNR, Inst Food Sci, Via Roma 64, I-83100 Avellino, Italy.; Siani, A (corresponding author), Univ Campania Luigi Vanvitelli, Dept Precis Med, Sch Med & Surg, S Andrea Delle Dame Via L Crecchio 7, I-80138 Naples, Italy.
EM alfonso.siani@isa.cnr.it
RI Borriello, Margherita/AAC-5609-2022; Sirangelo, Ivana/HSG-1357-2023;
   Lauria, Fabio/ABF-6895-2020; Hebestreit, Antje/AAW-7161-2020
OI Lauria, Fabio/0000-0002-1663-1582; RUSSO, PAOLA/0000-0002-3603-0143;
   Hebestreit, Antje/0000-0001-7354-5958; Sirangelo,
   Ivana/0000-0002-6408-4990
FU European Commission [266044]
FX This work was supported by the European Commission within the Seventh
   RTD Framework Program Contract No. 266044.
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NR 49
TC 2
Z9 2
U1 0
U2 9
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD OCT
PY 2022
VL 14
IS 19
AR 4135
DI 10.3390/nu14194135
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 5H8EY
UT WOS:000867907500001
PM 36235787
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Rumora, AE
   Guo, K
   Hinder, LM
   O'Brien, PD
   Hayes, JM
   Hur, J
   Feldman, EL
AF Rumora, Amy E.
   Guo, Kai
   Hinder, Lucy M.
   O'Brien, Phillipe D.
   Hayes, John M.
   Hur, Junguk
   Feldman, Eva L.
TI A High-Fat Diet Disrupts Nerve Lipids and Mitochondrial Function in
   Murine Models of Neuropathy
SO FRONTIERS IN PHYSIOLOGY
LA English
DT Article
DE dyslipidemia; prediabetes; mitochondria; obesity; neuropathy;
   lipidomics; high-fat diet; metabolic syndrome
ID DIABETIC-NEUROPATHY; RISK-FACTORS; BIOENERGETICS; CARDIOLIPIN; PLASMA;
   POLYNEUROPATHY; HOMEOSTASIS; OBESITY; STRESS; PAIN
AB As the prevalence of prediabetes and type 2 diabetes (T2D) continues to increase worldwide, accompanying complications are also on the rise. The most prevalent complication, peripheral neuropathy (PN), is a complex process which remains incompletely understood. Dyslipidemia is an emerging risk factor for PN in both prediabetes and T2D, suggesting that excess lipids damage peripheral nerves; however, the precise lipid changes that contribute to PN are unknown. To identify specific lipid changes associated with PN, we conducted an untargeted lipidomics analysis comparing the effect of high-fat diet (HFD) feeding on lipids in the plasma, liver, and peripheral nerve from three strains of mice (BL6, BTBR, and BKS). HFD feeding triggered distinct strain- and tissue-specific lipid changes, which correlated with PN in BL6 mice versus less robust murine models of metabolic dysfunction and PN (BTBR and BKS mice). The BL6 mice showed significant changes in neutral lipids, phospholipids, lysophospholipids, and plasmalogens within the nerve. Sphingomyelin (SM) and lysophosphatidylethanolamine (LPE) were two lipid species that were unique to HFD BL6 sciatic nerve compared to other strains (BTBR and BKS). Plasma and liver lipids were significantly altered in all murine strains fed a HFD independent of PN status, suggesting that nerve-specific lipid changes contribute to PN pathogenesis. Many of the identified lipids affect mitochondrial function and mitochondrial bioenergetics, which were significantly impaired in ex vivo sural nerve and dorsal root ganglion sensory neurons. Collectively, our data show that consuming a HFD dysregulates the nerve lipidome and mitochondrial function, which may contribute to PN in prediabetes.
C1 [Rumora, Amy E.; Guo, Kai; Hinder, Lucy M.; O'Brien, Phillipe D.; Hayes, John M.; Hur, Junguk; Feldman, Eva L.] Univ Michigan, Dept Neurol, Ann Arbor, MI 48109 USA.
   [Rumora, Amy E.] Columbia Univ, Dept Neurol, New York, NY 10027 USA.
   [Guo, Kai; Hur, Junguk] Univ North Dakota, Dept Biomed Sci, Grand Forks, ND USA.
C3 University of Michigan System; University of Michigan; Columbia
   University; University of North Dakota Grand Forks
RP Rumora, AE (corresponding author), Univ Michigan, Dept Neurol, Ann Arbor, MI 48109 USA.; Rumora, AE (corresponding author), Columbia Univ, Dept Neurol, New York, NY 10027 USA.
EM aer2219@cumc.columbia.edu
RI Guo, Kai/HCH-0903-2022; Hur, Junguk/J-6229-2019; O'Brien,
   Phillipe/W-4268-2019; Guo, Kai/AFA-3878-2022
OI Guo, Kai/0000-0002-4651-781X; Hur, Junguk/0000-0002-0736-2149
FU U.S. National Institutes of Health (NIH) National Institute of Diabetes
   and Digestive and Kidney Diseases (NIDDK); NIDDK DiaComp Award [R24
   DK082841, R01 DK107956, R21 NS102924, K99/R00 DK119366, F32
   1F32DK112642]; Novo Nordisk Foundation [DK076169]; American Diabetes
   Association [NNF14OC0011633]; NeuroNetwork for Emerging Therapies at the
   University of Michigan; A. Alfred Taubman Medical Research Institute
FX This work was provided by U.S. National Institutes of Health (NIH)
   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
   Grants R24 DK082841 (to EF), R01 DK107956 (to EF), R21 NS102924 (to EF),
   K99/R00 DK119366 (to AR) and F32 1F32DK112642 (to AR); the NIDDK DiaComp
   Award DK076169 (to EF); Novo Nordisk Foundation Grant NNF14OC0011633 (to
   EF); the American Diabetes Association, the NeuroNetwork for Emerging
   Therapies at the University of Michigan; and the A. Alfred Taubman
   Medical Research Institute.
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NR 65
TC 16
Z9 18
U1 0
U2 15
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1664-042X
J9 FRONT PHYSIOL
JI Front. Physiol.
PD AUG 22
PY 2022
VL 13
AR 921942
DI 10.3389/fphys.2022.921942
PG 15
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA 5A3HW
UT WOS:000862781800001
PM 36072849
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Mela, V
   Ruiz-Limón, P
   Balongo, M
   Rad, HM
   Subiri-Verdugo, A
   Gonzalez-Jimenez, A
   Soler, R
   Ocaña, L
   el Azzouzi, H
   Tinahones, FJ
   Valdivielso, P
   Murri, M
AF Mela, Virginia
   Ruiz-Limon, Patricia
   Balongo, Manuel
   Motahari Rad, Hanieh
   Subiri-Verdugo, Alba
   Gonzalez-Jimenez, Andres
   Soler, Rocio
   Ocana, Luis
   el Azzouzi, Hamid
   Tinahones, Francisco J.
   Valdivielso, Pedro
   Murri, Mora
TI Mitochondrial Homeostasis in Obesity-related Hypertriglyceridemia
SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Article
DE hypertriglyceridemia; metabolism; mitochondrial fitness; mitophagy;
   obesity
ID VISCERAL ADIPOSE-TISSUE; METABOLIC SYNDROME; OXIDATIVE STRESS;
   GENE-EXPRESSION; DYSFUNCTION; PARKIN; FAT; MITOPHAGY; MECHANISMS;
   GLUCOSE
AB Context The prevalence of obesity and hypertriglyceridemia is an alarming worldwide health issue. Mitochondria play a central role in these disorders as they control cell metabolism. Objective The aim of the present study was to characterize mitochondrial homeostasis in subcutaneous and visceral adipose tissue (SAT and VAT) in grade III obese patients with and without hypertriglyceridemia. Moreover, this study presents the evaluation of mitochondrial fitness as a marker for hypertriglyceridemia improvement. Patients Eight control and 12 hypertriglyceridemic (HTG) grade III obese subjects undergoing bariatric surgery were included. Main Outcome Measures Anthropometric and biochemical data were obtained before and 3 months after surgery. Mitochondrial homeostasis was evaluated by mitochondrial DNA (mtDNA), gene expression and protein abundance in SAT and VAT. Results Mitophagy-related gene expression was increased in HTG SAT and VAT, while mitochondrial marker gene expression and mtDNA were decreased, indicating an altered mitochondrial homeostasis in HTG. Mitophagy protein abundance was increased in VAT of those subjects that did not improve their levels of triglycerides after bariatric surgery, whereas mitochondrial protein was decreased in the same tissue. Indeed, triglyceride levels positively correlated with mitophagy-related genes and negatively with mitochondrial content markers. Moreover, mitochondria content and mitophagy markers seem to be significant predictors of hypertriglyceridemia and hypertriglyceridemia remission. Conclusions Mitochondrial homeostasis of adipose tissue is altered in hypertriglyceridemic patients. At the protein level, mitochondria content and mitophagy are potential markers of hypertriglyceridemia remission in obese patients after bariatric surgery. These results may contribute to the implementation of a clinical approach for personalized medicine.
C1 [Mela, Virginia; Ruiz-Limon, Patricia; Balongo, Manuel; Motahari Rad, Hanieh; Subiri-Verdugo, Alba; Tinahones, Francisco J.; Murri, Mora] Hosp Clin Virgen de la Victoria, Inst Invest Biomed Malaga IBIMA, Unidad Gest Clin Endocrinol & Nutr, Malaga 29010, Spain.
   [Mela, Virginia; Tinahones, Francisco J.; Valdivielso, Pedro] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr CIBEROBN, Malaga 29010, Spain.
   [Mela, Virginia; Tinahones, Francisco J.] Univ Malaga, Fac Med, Dept Med & Dermatol, Malaga 29010, Spain.
   [Motahari Rad, Hanieh] Tarbiat Modares Univ, Fac Biol Sci, Dept Mol Genet, Tehran 14115154, Iran.
   [Gonzalez-Jimenez, Andres] ECAI Bioinformat Inst Biomed Res Malaga IBIMA, Malaga 29010, Spain.
   [Soler, Rocio; Ocana, Luis] Hosp Clin Virgen de la Victoria, Unidad Gest Clin Cirugia Gen & Digest, Malaga 29010, Spain.
   [el Azzouzi, Hamid] Erasmus MC, Dept Mol Genet, NL-3436 HR Rotterdam, Netherlands.
   [Valdivielso, Pedro] Hosp Univ Virgen de la Victoria, Ctr Invest Med Sanitarias, UGC Med Interne, CIMES, Malaga 29010, Spain.
C3 Instituto de Investigacion Biomedica de Malaga y Plataforma en
   Nanomedicina (IBIMA); Universidad de Malaga; Instituto de Salud Carlos
   III; CIBER - Centro de Investigacion Biomedica en Red; CIBEROBN;
   Universidad de Malaga; Tarbiat Modares University; Instituto de
   Investigacion Biomedica de Malaga y Plataforma en Nanomedicina (IBIMA);
   Erasmus University Rotterdam; Erasmus MC; Universidad de Malaga
RP Mela, V; Murri, M (corresponding author), Univ Hosp Malaga Virgen de la Victoria, Endocrine Dis Res Grp, Biomed Res Inst Malaga IBIMA, Campus Teatinos S-N, Malaga 29010, Spain.
EM virginiamelarivas@gmail.com; moramurri@gmail.com
RI Tinahones, Francisco/AAB-2882-2020; Limon, Patricia/AAD-3424-2021;
   Motahari Rad, Hanieh/KYP-8104-2024; Gonzalez-Jimenez,
   Andres/E-5165-2018; Mela, Virginia/N-4664-2017
OI Gonzalez-Jimenez, Andres/0000-0002-7059-1577; Motahari Rad,
   Hanieh/0000-0003-2386-2845; Tinahones, Francisco J/0000-0001-6871-4403;
   Mela, Virginia/0000-0001-7702-0972
FU ISCIII [PI19/00507]; FEDER funds; Malaga University, Junta de Andalucia;
   FEDER funds [CB06/03/0018, PI-0297-2018]; Consejeria de Salud y Familia,
   Junta de Andalucia, Spain; Junta de Andalucia (PAIDI) [CTS-159]; 
   [UMA18-FEDERJA-285]
FX This work was supported by Principal Investigator grants to M.M. by
   PI19/00507 from ISCIII and cofunded by FEDER funds. M.M. is also
   supported by UMA18-FEDERJA-285 cofunded by Malaga University, Junta de
   Andalucia and FEDER funds, CB06/03/0018 and PI-0297-2018 cofunded by
   FEDER funds, and Consejeria de Salud y Familia, Junta de Andalucia,
   Spain. P.V. is supported by Junta de Andalucia (PAIDI, CTS-159).
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NR 44
TC 4
Z9 7
U1 2
U2 4
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0021-972X
EI 1945-7197
J9 J CLIN ENDOCR METAB
JI J. Clin. Endocrinol. Metab.
PD JUL 14
PY 2022
VL 107
IS 8
BP 2203
EP 2215
DI 10.1210/clinem/dgac332
EA MAY 2022
PG 13
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 3A9DE
UT WOS:000811191900001
PM 35608825
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Genitsaridi, SM
   Karampatsou, S
   Papageorgiou, I
   Mantzou, A
   Papathanasiou, C
   Kassari, P
   Paltoglou, G
   Kourkouti, C
   Charmandari, E
AF Genitsaridi, Sofia-Maria
   Karampatsou, Sofia
   Papageorgiou, Ifigeneia
   Mantzou, Aimilia
   Papathanasiou, Chryssanthi
   Kassari, Penio
   Paltoglou, George
   Kourkouti, Christie
   Charmandari, Evangelia
TI Hair Cortisol Concentrations in Overweight and Obese Children and
   Adolescents
SO HORMONE RESEARCH IN PAEDIATRICS
LA English
DT Article
DE Hair cortisol concentrations; Obesity; Overweight; Childhood;
   Adolescence
ID PITUITARY-ADRENAL AXIS; BODY-MASS INDEX; SCALP HAIR; METABOLIC SYNDROME;
   ABDOMINAL OBESITY; WOMEN; MEN; DYSREGULATION; STRESS
AB Introduction: Obesity in childhood and adolescence is associated with complications that resemble those seen in hypercortisolism. Hair cortisol concentration (HCC) in children is a reliable marker of long-term endogenous cortisol concentrations. We determined HCC in overweight and obese children and adolescents, and examined the relation between HCC and other cardiometabolic parameters. Methods: Three hundred children and adolescents aged 4-18 years (mean age +/- standard error of the mean [SEM]: 10.49 +/- 0.15 years; 140 [46.7%] obese, 94 [31.3%] overweight, 66 [22%] of normal BMI; 76 males, 224 females) were studied prospectively. Blood samples for determination of hematological, biochemical, and endocrinologic parameters were obtained. Systolic (SBP) and diastolic blood pressure (DBP) was determined. Scalp hair samples were collected from the posterior vertex, and HCC was measured using an electrochemiluminescence immunoassay. Results: Obese subjects had significantly higher SBP, DBP, waist and hip circumferences, waist-to-hip ratio, waist-to-height ratio, ALT, gamma-GT, triglycerides, apolipoprotein-B, insulin, and HbA(1C) concentrations than overweight and normal-BMI subjects. HCC did not differ significantly among the three groups of subjects (mean +/- SEM: 8.74 +/- 0.43 vs. 8.88 +/- 0.52 vs. 9.33 +/- 0.72, all p > 0.05). No significant association was noted between HCC and cardiometabolic or body composition parameters. HCC was significantly higher in prepubertal girls than prepubertal boys (9.45 +/- 0.38 vs. 7.35 +/- 0.39, p = 0.007). Conclusion: In our study, overweight and obesity was not associated with elevated HCC. Furthermore, no association was found between HCC with cardiometabolic parameters and fat mass. Further studies are required to delineate the association between overweight/obesity and HCC.
C1 [Genitsaridi, Sofia-Maria; Karampatsou, Sofia; Papageorgiou, Ifigeneia; Mantzou, Aimilia; Papathanasiou, Chryssanthi; Kassari, Penio; Paltoglou, George; Kourkouti, Christie; Charmandari, Evangelia] Natl & Kapodistrian Univ Athens, Sch Med, Aghia Sophia Childrens Hosp, Div Endocrinol Metab & Diabet,Dept Pediat 1, Athens, Greece.
   [Charmandari, Evangelia] Acad Athens, Biomed Res Fdn, Ctr Clin Expt Surg & Translat Res, Div Endocrinol & Metab, Athens, Greece.
C3 National & Kapodistrian University of Athens; Athens Medical School; The
   Aghia Sophia Children's Hospital; Academy of Athens
RP Genitsaridi, SM (corresponding author), Natl & Kapodistrian Univ Athens, Aghia Sophia Childrens Hosp, Dept Pediat 1, Sch Med, Thivon & Papadiamantopoulou St, GR-11527 Athens, Greece.
EM sgenitsaridi@gmail.com
RI Charmandari, Evangelia/AAF-2038-2019; Paltoglou, George/B-6944-2019
OI MANTZOU, EMILIA/0000-0001-6606-8647; Charmandari,
   Evangelia/0000-0002-0851-6998; Paltoglou, George/0000-0003-4300-7061
FU national funds through Research Funding of the National and Kapodistrian
   University of Athens (UOA) Medical School, Athens, Greece
FX This work was supported by national funds through Research Funding of
   the National and Kapodistrian University of Athens (UOA) Medical School,
   Athens, Greece.
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NR 35
TC 21
Z9 21
U1 2
U2 6
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1663-2818
EI 1663-2826
J9 HORM RES PAEDIAT
JI Horm. Res. Paediatr.
PD MAR
PY 2020
VL 92
IS 4
BP 229
EP 236
DI 10.1159/000504913
PG 8
WC Endocrinology & Metabolism; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Pediatrics
GA KX8GP
UT WOS:000522113700002
PM 31851969
DA 2025-06-11
ER

PT J
AU Feng, K
   Chen, HF
   Xu, C
AF Feng, Kai
   Chen, Hongfang
   Xu, Chen
TI Chondro-protective effects of celastrol on osteoarthritis through
   autophagy activation and NF-κB signaling pathway inhibition
SO INFLAMMATION RESEARCH
LA English
DT Article
DE Osteoarthritis; Celastrol; Autophagy; Apoptosis; NF-kappa b
ID AUTOIMMUNE ARTHRITIS; METABOLIC SYNDROME; OXIDATIVE STRESS; CARTILAGE
   DAMAGE; APOPTOSIS; CELLS; CHONDROCYTES; SUPPRESSES; INDUCTION; PROTECTS
AB Objective Osteoarthritis (OA) is a degenerative articular cartilage disease accompanied by superfluous apoptosis of chondrocytes in the elderly. Celastrol is a potent bioactive medicine which can exert anti-inflammatory and anti-oxidative effects in various diseases. This study aimed to elucidate the possible role of celastrol in OA as well as the specific mechanism of celastrol in vitro and in vivo. Methods Autophagy-related biomarkers and apoptotic molecules were evaluated by PCR, Western blot and immunofluorescence staining. The level of autophagy was assessed by MDC staining and transmission electron microscopy. To study the downstream signaling pathway, nuclear factor kappa B (NF-kappa B) signaling pathway-related proteins were examined by Western blot. Moreover, an anterior cruciate ligament transection (ACLT) rat model was established to observe the protective effect of celastrol on rat cartilage. Results We found celastrol ameliorated IL-1 beta-induced chondrocyte apoptosis and increased the expression of LC3-II and Beclin-1. In addition, the suppression of celastrol-induced autophagy by 3-methyladenine (3MA) prevented the protective effect of celastrol in chondrocytes. Moreover, celastrol decreased the IL-1 beta-stimulated phosphorylation degree of I kappa B alpha and P65. We also found PDTC (a known NF-kappa B pathway inhibitor) can promote the activation of autophagy and attenuate the apoptosis of chondrocytes. Meanwhile, the results of rat ACLT model revealed the same effect as in vitro experiments. Conclusions In summary, celastrol protected against chondrocyte apoptosis by promoting autophagy and inhibiting NF-kappa B signaling pathway in vitro and in vivo.
C1 [Feng, Kai] Shanghai Jiao Tong Univ, Dept Orthped Surg, Affiliated Peoples Hosp 6, 600 Yishan Rd, Shanghai 200233, Peoples R China.
   [Chen, Hongfang; Xu, Chen] Shanghai Jiao Tong Univ, Peoples Hosp 9, Dept Orthped, Shanghai Key Lab Orthped Implants,Sch Med, Shanghai 200011, Peoples R China.
C3 Shanghai Jiao Tong University; Shanghai Jiao Tong University
RP Feng, K (corresponding author), Shanghai Jiao Tong Univ, Dept Orthped Surg, Affiliated Peoples Hosp 6, 600 Yishan Rd, Shanghai 200233, Peoples R China.; Xu, C (corresponding author), Shanghai Jiao Tong Univ, Peoples Hosp 9, Dept Orthped, Shanghai Key Lab Orthped Implants,Sch Med, Shanghai 200011, Peoples R China.
EM jsycfk@126.com; 116126@sh9hospital.org
RI Feng, Kai/JQI-9878-2023
FU Medical-Engineering Joint Fund of Shanghai Jiaotong University
   [YG2017QN02]
FX This work was supported by the Medical-Engineering Joint Fund of
   Shanghai Jiaotong University (YG2017QN02)
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NR 53
TC 34
Z9 36
U1 4
U2 28
PU SPRINGER BASEL AG
PI BASEL
PA PICASSOPLATZ 4, BASEL, 4052, SWITZERLAND
SN 1023-3830
EI 1420-908X
J9 INFLAMM RES
JI Inflamm. Res.
PD APR
PY 2020
VL 69
IS 4
BP 385
EP 400
DI 10.1007/s00011-020-01327-z
EA FEB 2020
PG 16
WC Cell Biology; Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Immunology
GA KU9AS
UT WOS:000517021800001
PM 32112120
DA 2025-06-11
ER

PT J
AU Xiao, YJ
   Xia, JJ
   Ke, YB
   Cheng, JQ
   Yuan, JH
   Wu, S
   Lv, ZQ
   Huang, SL
   Kim, JH
   Wong, SYS
   Yeoh, EK
   Colditz, GA
   Su, XF
AF Xiao, Yunjun
   Xia, Junjie
   Ke, Yuebin
   Cheng, Jinquan
   Yuan, Jianhui
   Wu, Shuang
   Lv, Ziquan
   Huang, Suli
   Kim, Jean H.
   Wong, Samuel Yeung-shan
   Yeoh, Eng-kiong
   Colditz, Graham A.
   Su, Xuefen
TI Effects of nut consumption on selected inflammatory markers: a
   systematic review and meta-analysis of randomized controlled trials
SO NUTRITION
LA English
DT Review
DE Nut consumption; Inflammatory markers; Intercellular adhesion molecule;
   Randomized controlled trials; Meta-analysis
ID CARDIOVASCULAR RISK-FACTORS; CORONARY-HEART-DISEASE; C-REACTIVE PROTEIN;
   ENDOTHELIAL FUNCTION; INSULIN-RESISTANCE; METABOLIC SYNDROME; WALNUT
   CONSUMPTION; DIABETES-MELLITUS; OXIDATIVE STRESS; BODY-COMPOSITION
AB Objective: Several randomized controlled trials (RCTs) have assessed the effects of nut consumption on inflammatory markers. However, the results have been inconsistent. The aim of this meta-analysis of RCTs was to quantitatively evaluate the effects of nut consumption on selected inflammatory markers.
   Methods: PubMed, Embase, Cochrane Library database, and Google Scholar were searched for published RCTs that reported the effects of nuts on inflammatory markers as primary or secondary outcomes in an adult population (aged >= 18 y). Summary estimates of weighted mean differences (WMDs) and 95% confidence intervals (CIs) were calculated using random-effects meta-analysis.
   Results: Twenty-three RCTs met the inclusion criteria. Overall, nut consumption significantly reduced the levels of intercellular adhesion molecule (ICAM)-1 (WMD, -0.17; 95% CI, -0.32 to -0.03; P = 0.01), but had no significant effect on other inflammatory markers. In the subgroup analyses by nut types, mixed nuts had a significant effect on ICAM-1 reduction. The significant effect of nuts on ICAM-1 reduction was only observed in parallel, but not crossover RCTs. Additionally, nut consumption significantly reduced ICAM-1 and vascular cell adhesion molecule-1 levels in long-term (>= 12 wk), but not short-term (<12 wk) RCTs. No significant heterogeneity or publication bias was observed in the studies included.
   Conclusions: Nut consumption significantly reduced ICAM-1 levels, but had no effect on other inflammatory markers. More studies are needed to assess the effects of nuts on inflammation. (C) 2018 Elsevier Inc. All rights reserved.
C1 [Xiao, Yunjun; Xia, Junjie; Ke, Yuebin; Cheng, Jinquan; Yuan, Jianhui; Wu, Shuang; Lv, Ziquan; Huang, Suli] Shenzhen Ctr Dis Control & Prevent, Shenzhen Key Lab Mol Epidemiol, Shenzhen, Peoples R China.
   [Kim, Jean H.; Wong, Samuel Yeung-shan; Yeoh, Eng-kiong; Su, Xuefen] Chinese Univ Hong Kong, Fac Med, Sch Publ Hlth & Primary Care, Hong Kong, Hong Kong, Peoples R China.
   [Colditz, Graham A.] Washington Univ, Sch Med, Alvin J Siteman Canc Ctr, St Louis, MO 63110 USA.
   [Colditz, Graham A.] Washington Univ, Sch Med, Dept Surg, St Louis, MO 63110 USA.
C3 Shenzhen Center for Disease Control & Prevention (SZCDC); Chinese
   University of Hong Kong; Siteman Cancer Center; Washington University
   (WUSTL); Washington University (WUSTL)
RP Su, XF (corresponding author), Chinese Univ Hong Kong, Fac Med, Sch Publ Hlth & Primary Care, Hong Kong, Hong Kong, Peoples R China.; Colditz, GA (corresponding author), Washington Univ, Sch Med, Alvin J Siteman Canc Ctr, St Louis, MO 63110 USA.; Colditz, GA (corresponding author), Washington Univ, Sch Med, Dept Surg, St Louis, MO 63110 USA.
EM Xuefensu@cuhk.edu.hk
RI Liang, Chen/HNP-5916-2023; xia, junjie/LNQ-1011-2024; yuan,
   jianhui/GQA-4825-2022; Wu, Shuang/KIH-6794-2024; Wong, Samuel
   Yeung-shan/D-7311-2013; Colditz, Graham/A-3963-2009
OI Wong, Samuel Yeung-shan/0000-0003-0934-6385; Colditz,
   Graham/0000-0002-7307-0291
FU National Natural Science Foundation of China [81402672]; Shenzhen
   Science and Technology Planning Project [JCYJ20170306160008504]; Sanming
   Project of Medicine in Shenzhen [SZSM201611068]
FX This work was supported by grants from the National Natural Science
   Foundation of China (81402672), Shenzhen Science and Technology Planning
   Project (JCYJ20170306160008504), and Sanming Project of Medicine in
   Shenzhen (SZSM201611068). YX and XS designed the study and drafted and
   revised the manuscript. YX, JX, YK, SW, ZL, and SH identified relevant
   articles and extracted and analyzed data. JC, JY, JHK, SYW, EK, and GAC
   commented and revised the manuscript. All of the authors read and
   approved the final manuscript. The authors have no conflicts of interest
   to declare.
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NR 63
TC 28
Z9 28
U1 0
U2 13
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0899-9007
EI 1873-1244
J9 NUTRITION
JI Nutrition
PD OCT
PY 2018
VL 54
BP 129
EP 143
DI 10.1016/j.nut.2018.02.017
PG 15
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA GU5JP
UT WOS:000445322100020
PM 29852452
DA 2025-06-11
ER

PT J
AU Zelber-Sagi, S
   Salomone, F
   Mlynarsky, L
AF Zelber-Sagi, Shira
   Salomone, Federico
   Mlynarsky, Liat
TI The Mediterranean dietary pattern as the diet of choice for
   non-alcoholic fatty liver disease: Evidence and plausible mechanisms
SO LIVER INTERNATIONAL
LA English
DT Review
DE fish oil; fruits; Mediterranean diet; non-alcoholic fatty liver disease;
   olive oil; vegetables
ID PROCESSED MEAT CONSUMPTION; WHOLE-GRAIN WHEAT; MODEST
   ALCOHOL-CONSUMPTION; HEPATIC OXIDATIVE STRESS; OLIVE OIL;
   INSULIN-RESISTANCE; RISK-FACTORS; CARDIOVASCULAR-DISEASE; METABOLIC
   SYNDROME; DIABETES-MELLITUS
AB Non-alcoholic fatty liver disease (NAFLD) has become a major global health burden, leading to increased risk for cirrhosis, hepatocellular carcinoma, type-2 diabetes and cardiovascular disease. Lifestyle intervention aiming at weight reduction is the most established treatment. However, changing the dietary composition even without weight loss can also reduce steatosis and improve metabolic alterations as insulin resistance and lipid profile. The Mediterranean diet (MD) pattern has been proposed as appropriate for this goal, and was recommended as the diet of choice for the treatment of NAFLD by the EASL-EASD-EASO Clinical Practice Guidelines. The MD has an established superiority in long term weight reduction over low fat diet, but it improves metabolic status and steatosis even without it. However, the effect on liver inflammation and fibrosis was tested only in few observational studies with positive results. Furthermore, considering the strong association between NAFLD and diabetes and CVD, the MD has a highly established advantage in prevention of these diseases, demonstrated in randomized clinical trials. The individual components of the MD such as olive oil, fish, nuts, whole grains, fruits, and vegetables, have been shown to beneficially effect or negatively correlate with NAFLD, while consumption of components that characterize a Western dietary pattern as soft drinks, fructose, meat and saturated fatty acids have been shown to have detrimental association with NAFLD. In this review we will cover the epidemiological evidence and the plausible molecular mechanisms by which the MD as a whole and each of its components can be of benefit in NAFLD.
C1 [Zelber-Sagi, Shira] Univ Haifa, Sch Publ Hlth, Haifa, Israel.
   [Zelber-Sagi, Shira; Mlynarsky, Liat] Tel Aviv Med Ctr & Sch Med, Liver Unit, Dept Gastroenterol, Tel Aviv, Israel.
   [Salomone, Federico] Azienda Sanit Prov Catania, Osped Acireale, Div Gastroenterol, Catania, Italy.
   [Mlynarsky, Liat] Tel Aviv Univ, Sackler Fac Med, Tel Aviv, Israel.
C3 University of Haifa; Tel Aviv University; Sackler Faculty of Medicine;
   Tel Aviv University; Sackler Faculty of Medicine
RP Zelber-Sagi, S (corresponding author), Tel Aviv Med Ctr & Sch Med, Liver Unit, Dept Gastroenterol, Tel Aviv, Israel.
EM zelbersagi@bezeqint.net
RI Salomone, Federico/R-6598-2016
OI Salomone, Federico/0000-0001-5264-2935
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NR 158
TC 196
Z9 212
U1 0
U2 52
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1478-3223
EI 1478-3231
J9 LIVER INT
JI Liver Int.
PD JUL
PY 2017
VL 37
IS 7
BP 936
EP 949
DI 10.1111/liv.13435
PG 14
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA EY4CB
UT WOS:000403922800001
PM 28371239
DA 2025-06-11
ER

PT J
AU Hu, X
   Tanaka, N
   Guo, R
   Lu, Y
   Nakajima, T
   Gonzalez, FJ
   Aoyama, T
AF Hu, Xiao
   Tanaka, Naoki
   Guo, Ran
   Lu, Yu
   Nakajima, Takero
   Gonzalez, Frank J.
   Aoyama, Toshifumi
TI PPARα protects against trans-fatty-acid-containing diet-induced
   steatohepatitis
SO JOURNAL OF NUTRITIONAL BIOCHEMISTRY
LA English
DT Article
DE trans-Fatty acid; PPAR alpha; Nuclear factor-kappa B; Osteopontin;
   Toll-like receptor; Inflammasome
ID NF-KAPPA-B; LIVER-DISEASE; NONALCOHOLIC STEATOHEPATITIS;
   HEPATOCELLULAR-CARCINOMA; CHOLESTEROL LEVELS; OXIDATIVE STRESS;
   DOWN-REGULATION; OSTEOPONTIN; INFLAMMASOMES; ALTER
AB Consumption of trans-fatty acids (TFA), unsaturated fatty acids (FA) containing trans double bonds, is a risk factor for metabolic syndrome and steatohepatitis. Peroxisome proliferator-activated receptor alpha (PPAR alpha) is a master regulator of hepatic lipid homeostasis. To examine the contribution of PPAR alpha to changes in liver phenotypes induced by TFA, two diets were used: a purified control diet and an isocaloric diet in which most of the soybean oil, a major source of FA in the diet, was replaced with TFA-rich shortening. The diets were fed to wild-type and Ppara-null mice for 2 months. Ppara-null mice fed a TFA-containing diet showed more severe hepatic steatosis and liver damage compared with similarly treated wild-type mice, as revealed by increased hepatic triglyceride (TG) contents and serum alanine aminotransferase activities. While the TFA-rich diet increased the hepatic expression of enzymes involved in de novo FA synthesis and decreased TG-hydrolyzing enzymes in both genotypes, the expression of FA-catabolizing enzymes was decreased in Ppara-null mice, resulting in more severe hepatosteatosis. Additionally, the expression levels of key contributors to inflammation, such as osteopontin, were increased, and nuclear factor-kappa B was activated in TFA-containing diet-fed Ppara-null mice. Enhanced inflammatory signaling in these mice was presumably mediated by toll-like receptor 2, with no accompanying inflammasome activation. Collectively, these results suggest a protective role for PPARa. in the pathological changes in the liver following TFA consumption. PPAR alpha might prevent TFA-containing diet-induced steatohepatitis. (C) 2016 Elsevier Inc. All rights reserved.
C1 [Hu, Xiao; Tanaka, Naoki; Guo, Ran; Lu, Yu; Nakajima, Takero; Aoyama, Toshifumi] Shinshu Univ, Grad Sch Med, Dept Metab Regulat, Matsumoto, Nagano 3908621, Japan.
   [Gonzalez, Frank J.] NCI, Lab Metab, Ctr Canc Res, NIH, Bethesda, MD 20892 USA.
C3 Shinshu University; National Institutes of Health (NIH) - USA; NIH
   National Cancer Institute (NCI)
RP Tanaka, N (corresponding author), Shinshu Univ, Grad Sch Med, Dept Metab Regulat, Matsumoto, Nagano 3908621, Japan.
EM naopi@shinshu-u.ac.jp
RI Gonzalez, Francisco/GWV-3999-2022; Hu, Xiaoyuan/HTM-3321-2023
OI Tanaka, Naoki/0000-0002-3212-3836; Gonzalez, Frank/0000-0002-7990-2140
FU Intramural NIH HHS [Z01 BC005561] Funding Source: Medline
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NR 45
TC 31
Z9 33
U1 3
U2 22
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0955-2863
EI 1873-4847
J9 J NUTR BIOCHEM
JI J. Nutr. Biochem.
PD JAN
PY 2017
VL 39
BP 77
EP 85
DI 10.1016/j.jnutbio.2016.09.015
PG 9
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA EE4IT
UT WOS:000389566200009
PM 27816763
OA Green Submitted, Green Accepted
DA 2025-06-11
ER

PT J
AU Silva, SA
   Gobbo, MG
   Pinto-Fochi, ME
   Rafacho, A
   Taboga, SR
   Almeida, EA
   Góes, RM
   Ribeiro, DL
AF Silva, Silas Amancio
   Gobbo, Marina Guimaraes
   Pinto-Fochi, Maria Etelvina
   Rafacho, Alex
   Taboga, Sebastiao Roberto
   Almeida, Eduardo Alves
   Goes, Rejane Maira
   Ribeiro, Daniele Lisboa
TI Prostate hyperplasia caused by long-term obesity is characterized by
   high deposition of extracellular matrix and increased content of MMP-9
   and VEGF
SO INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY
LA English
DT Article
DE androgen receptor; hyperplasia; MMP-9; obesity; prostate; stromal
   remodelling
ID RAT VENTRAL PROSTATE; ESTROGEN-RECEPTOR; CHONDROITIN SULFATE; METABOLIC
   SYNDROME; OXIDATIVE STRESS; DIABETIC-RATS; DIETARY-FAT; CANCER;
   METALLOPROTEINASES; INFLAMMATION
AB Recent studies have shown a positive association of cancer and obesity, but the morphological and molecular mechanisms involved in this relationship are still unknown. This study analysed the impact of long-term obesity on rat prostate, focusing on stromal changes. Male adult Wistar rats were treated with high-fat diet to induce obesity, while the control group received a balanced diet. After 30weeks of feeding, the ventral prostate was analysed by immunohistochemistry for cell proliferation, smooth muscle -actin, vimentin, chondroitin sulphate and metalloproteinases (MMP-2 and 9). The content of androgen receptor (AR), oestrogen receptors (ERs) and vascular endothelial growth factor (VEGF) was measured by Western blotting, and activity of catalase and Glutathione-S-Transferase (GST) were quantified by enzymatic assay. Long-term obesity decreased testosterone plasma levels by 70% and resulted in stromal prostate hyperplasia, as evidenced by increased collagen fibres. Such stromal hyperplasia was associated with increased number of blood vessels and raised VEGF content, and increased expression of chondroitin sulphate, vimentin, -actin and MMP-9. In spite of the high cell density in prostate, the proliferative activity was lower in the prostates of obese rats, indicating that hyperplasia was established during the early phases in this obesity model. AR levels increased significantly, whereas the ER decreased in this group. Moreover, the levels of catalase and GST were changed considerably. These findings indicate that long-term obesity, besides disturbing the antioxidant control, causes intense stromal remodelling and release of factors that create an environment that can promote proliferative disorders in the gland, culminating with diffuse hyperplasia.
C1 [Silva, Silas Amancio; Ribeiro, Daniele Lisboa] Univ Fed Uberlandia UFU, Inst Biomed Sci, Histol Sect, Uberlandia, MG, Brazil.
   [Gobbo, Marina Guimaraes; Pinto-Fochi, Maria Etelvina; Taboga, Sebastiao Roberto; Goes, Rejane Maira] Univ Estadual Paulista UNESP, Inst Biosci Languages & Exact Sci, Dept Biol, Sao Jose Do Rio Preto, SP, Brazil.
   [Rafacho, Alex] Univ Fed Santa Catarina, Ctr Biol Sci, Dept Physiol Sci, Florianopolis, SC, Brazil.
   [Almeida, Eduardo Alves] Univ Estadual Paulista UNESP, Inst Biosci Languages & Exact Sci, Dept Chem & Environm Sci, Sao Jose Do Rio Preto, SP, Brazil.
C3 Universidade Federal de Uberlandia; Universidade Estadual Paulista;
   Universidade Federal de Santa Catarina (UFSC); Universidade Estadual
   Paulista
RP Ribeiro, DL (corresponding author), Univ Fed Uberlandia, Inst Ciencias Biomed ICBIM, Av Para 1720,Bloco 2E Sala 2E36, BR-38400902 Uberlandia, MG, Brazil.
EM dlribeiro@icbim.ufu.br
RI Gobbo, Marina/E-4674-2015; Góes, Rejane/AAY-5863-2020; Taboga,
   Sebastião/C-4937-2013; Ribeiro, Daniele/C-1176-2013; Rafacho,
   Alex/O-8609-2016; Goes, Rejane Maira/H-7954-2012; Alves de Almeida,
   Eduardo/B-7630-2012; Pinto-Fochi, Maria Etelvina/J-2436-2013
OI Rafacho, Alex/0000-0002-8637-6097; Goes, Rejane
   Maira/0000-0002-3622-460X; Taboga, Sebastiao/0000-0002-0970-4288; Alves
   de Almeida, Eduardo/0000-0002-4604-9104; Pinto-Fochi, Maria
   Etelvina/0000-0002-2205-0864
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NR 49
TC 34
Z9 36
U1 2
U2 15
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0959-9673
EI 1365-2613
J9 INT J EXP PATHOL
JI Int. J. Exp. Pathol.
PD FEB
PY 2015
VL 96
IS 1
BP 21
EP 30
DI 10.1111/iep.12107
PG 10
WC Pathology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pathology
GA CC4VX
UT WOS:000350353800003
PM 25529509
OA Green Published
DA 2025-06-11
ER

PT J
AU Rosenthal, T
AF Rosenthal, Talma
TI The effect of migration on hypertension and other cardiovascular risk
   factors: A review
SO JOURNAL OF THE AMERICAN SOCIETY OF HYPERTENSION
LA English
DT Review
DE Blood pressure; obesity; acculturation; diet; salt
ID CORONARY-HEART-DISEASE; FORMER SOVIET-UNION; SELF-REPORTED HEALTH;
   BLOOD-PRESSURE; JAPANESE-BRAZILIANS; METABOLIC SYNDROME; ETHIOPIAN
   IMMIGRANTS; ASIAN INDIANS; ACCULTURATION STATUS; SERVICE UTILIZATION
AB This comprehensive review summarizes the effects of migration and immigration on the development of hypertension and cardiovascular risk factors the world over Europe, Asia, Africa, North, South and Central America, China, Australia, and the Middle East. The process of acculturation that populations undergo as they move from small, rural, agricultural economies to industrialized towns and cities takes a toll on health and well-being. Surroundings change, a new culture has to be adapted to, a new language learned, lifestyles changed, physical activity often drastically reduced, and major changes made in eating habits as low-sodium low-fat diets are replaced by processed foods and high amounts of salt. Even populations that move from one westernized country to another undergo these traumas. The results: increased stress, hypertension, obesity and diabetes. These changes are more severe in the elderly than young people, who adapt to their new home more quickly. While such reactions to migration are seen worldwide, all populations do not respond the same, the result of constitutional differences and of the different cultures from whence they came. These dramatic changes put the onus on the governments and health services of the host countries to tailor prevention and treatment programs to these different populations proactive programs that are sorely lacking in most countries. The literature documents these phenomena, and can serve as a wake-up call to what is becoming a major worldwide health issue as populations shift and peoples struggle to adapt. (C) 2014 American Society of Hypertension. All rights reserved.
C1 Tel Aviv Univ, Sackler Sch Med, Dept Physiol & Pharmacol, Hypertens Res Unit, IL-69978 Tel Aviv, Israel.
C3 Tel Aviv University; Sackler Faculty of Medicine
RP Rosenthal, T (corresponding author), Tel Aviv Univ, Sackler Sch Med, Dept Physiol & Pharmacol, Hypertens Res Unit, IL-69978 Tel Aviv, Israel.
EM rtalma@post.tau.ac.il
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NR 134
TC 41
Z9 47
U1 0
U2 67
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1933-1711
EI 1878-7436
J9 J AM SOC HYPERTENS
JI J. Am. Soc. Hypertens.
PD MAR
PY 2014
VL 8
IS 3
BP 171
EP 191
DI 10.1016/j.jash.2013.12.007
PG 21
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Cardiovascular System & Cardiology
GA AF8MH
UT WOS:000334969800006
PM 24524887
DA 2025-06-11
ER

PT J
AU van Bilsen, M
   Daniels, A
   Brouwers, O
   Janssen, BJA
   Derks, WJA
   Brouns, AE
   Munts, C
   Schalkwijk, CG
   van der Vusse, GJ
   van Nieuwenhoven, FA
AF van Bilsen, Marc
   Daniels, Anneleen
   Brouwers, Olaf
   Janssen, Ben J. A.
   Derks, Wouter J. A.
   Brouns, Agnieszka E.
   Munts, Chantal
   Schalkwijk, Casper G.
   van der Vusse, Ger J.
   van Nieuwenhoven, Frans A.
TI Hypertension Is a Conditional Factor for the Development of Cardiac
   Hypertrophy in Type 2 Diabetic Mice
SO PLOS ONE
LA English
DT Article
ID GLYCATION END-PRODUCTS; DIASTOLIC DYSFUNCTION; CONTRACTILE DYSFUNCTION;
   CARDIOVASCULAR-DISEASE; MYOCARDIAL FIBROSIS; INSULIN-RESISTANCE;
   METABOLIC SYNDROME; GROWTH-FACTOR; DB/DB MICE; CARDIOMYOPATHY
AB Background: Type 2 diabetes is frequently associated with co-morbidities, including hypertension. Here we investigated if hypertension is a critical factor in myocardial remodeling and the development of cardiac dysfunction in type 2 diabetic db/db mice.
   Methods: Thereto, 14-wks-old male db/db mice and non-diabetic db/+ mice received vehicle or angiotensin II (AngII) for 4 wks to induce mild hypertension (n = 9-10 per group). Left ventricular (LV) function was assessed by serial echocardiography and during a dobutamine stress test. LV tissue was subjected to molecular and (immuno) histochemical analysis to assess effects on hypertrophy, fibrosis and inflammation.
   Results: Vehicle-treated diabetic mice neither displayed marked myocardial structural remodeling nor cardiac dysfunction. AngII-treatment did not affect body weight and fasting glucose levels, and induced a comparable increase in blood pressure in diabetic and control mice. Nonetheless, AngII-induced LV hypertrophy was significantly more pronounced in diabetic than in control mice as assessed by LV mass (increase +51% and +34%, respectively, p<0.01) and cardiomyocyte size (+53% and +31%, p<0.001). This was associated with enhanced LV mRNA expression of markers of hypertrophy and fibrosis and reduced activation of AMP-activated protein kinase (AMPK), while accumulation of Advanced Glycation End products (AGEs) and the expression levels of markers of inflammation were not altered. Moreover, AngII-treatment reduced LV fractional shortening and contractility in diabetic mice, but not in control mice.
   Conclusions: Collectively, the present findings indicate that type 2 diabetes in its early stage is not yet associated with adverse cardiac structural changes, but already renders the heart more susceptible to hypertension-induced hypertrophic remodeling.
C1 [van Bilsen, Marc; Daniels, Anneleen; Munts, Chantal; van der Vusse, Ger J.; van Nieuwenhoven, Frans A.] Maastricht Univ, Cardiovasc Res Inst Maastricht, Dept Physiol, Maastricht, Netherlands.
   [Brouwers, Olaf; Schalkwijk, Casper G.] Maastricht Univ, Cardiovasc Res Inst Maastricht, Dept Internal Med, Maastricht, Netherlands.
   [Janssen, Ben J. A.; Brouns, Agnieszka E.] Maastricht Univ, Cardiovasc Res Inst Maastricht, Dept Pharmacol, Maastricht, Netherlands.
   [Derks, Wouter J. A.] Maastricht Univ, Cardiovasc Res Inst Maastricht, Dept Cardiol, Maastricht, Netherlands.
C3 Maastricht University; Maastricht University; Maastricht University;
   Maastricht University
RP van Bilsen, M (corresponding author), Maastricht Univ, Cardiovasc Res Inst Maastricht, Dept Physiol, Maastricht, Netherlands.
EM m.vanbilsen@maastrichtuniversity.nl
RI Brouwers, Olaf/C-9820-2010; Bilsen, Marc/E-8342-2016
OI Derks, Wouter/0000-0002-6508-0078; Schalkwijk, Casper
   G/0000-0003-0190-2690; van Nieuwenhoven, Frans/0000-0002-5757-0069
FU CARIM; EU-FP6 [LSHM-CT-2005-018833]
FX This work was supported by grants from CARIM and EU-FP6
   (LSHM-CT-2005-018833, EUGeneHeart). The funders had no role in study
   design, data collection and analysis, decision to publish, or
   preparation of the manuscript.
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NR 39
TC 38
Z9 39
U1 0
U2 8
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JAN 9
PY 2014
VL 9
IS 1
AR e85078
DI 10.1371/journal.pone.0085078
PG 10
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 291XP
UT WOS:000329866300049
PM 24416343
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Jia, L
   Xing, J
   Ding, Y
   Shen, YC
   Shi, XH
   Ren, W
   Wan, M
   Guo, JJ
   Zheng, SJ
   Liu, Y
   Liang, XB
   Su, DM
AF Jia, Lu
   Xing, Jing
   Ding, Ying
   Shen, Yachen
   Shi, Xuhui
   Ren, Wei
   Wan, Meng
   Guo, Jianjin
   Zheng, Shujing
   Liu, Yun
   Liang, Xiubin
   Su, Dongming
TI Hyperuricemia Causes Pancreatic β-Cell Death and Dysfunction through
   NF-κB Signaling Pathway
SO PLOS ONE
LA English
DT Article
ID SERUM URIC-ACID; NITRIC-OXIDE PRODUCTION; METABOLIC SYNDROME;
   INSULIN-SECRETION; INDUCED APOPTOSIS; EXPRESSION; ISLETS; RELEASE;
   STRESS; MICE
AB Accumulating clinical evidence suggests that hyperuricemia is associated with an increased risk of type 2 diabetes. However, it is still unclear whether elevated levels of uric acid can cause direct injury of pancreatic beta-cells. In this study, we examined the effects of uric acid on beta-cell viability and function. Uric acid solution or normal saline was administered intraperitoneally to mice daily for 4 weeks. Uric acid-treated mice exhibited significantly impaired glucose tolerance and lower insulin levels in response to glucose challenge than did control mice. However, there were no significant differences in insulin sensitivity between the two groups. In comparison to the islets in control mice, the islets in the uric acid-treated mice were markedly smaller in size and contained less insulin. Treatment of beta-cells in vitro with uric acid activated the NF-kappa B signaling pathway through I kappa B alpha phosphorylation, resulting in upregulated inducible nitric oxide synthase (iNOS) expression and excessive nitric oxide (NO) production. Uric acid treatment also increased apoptosis and downregulated Bcl-2 expression in Min6 cells. In addition, a reduction in insulin secretion under glucose challenge was observed in the uric acid-treated mouse islets. These deleterious effects of uric acid on pancreatic beta-cells were attenuated by benzbromarone, an inhibitor of uric acid transporters, NOS inhibitor L-NMMA, and Bay 11-7082, an NF-kappa B inhibitor. Further investigation indicated that uric acid suppressed levels of MafA protein through enhancing its degradation. Collectively, our data suggested that an elevated level of uric acid causes beta-cell injury via the NF-kappa B-iNOS-NO signaling axis.
C1 [Jia, Lu; Xing, Jing; Ding, Ying; Shen, Yachen; Shi, Xuhui; Zheng, Shujing; Liu, Yun; Liang, Xiubin; Su, Dongming] Nanjing Med Univ, Ctr Metab Dis Res, Nanjing, Jiangsu, Peoples R China.
   [Su, Dongming] Nanjing Med Univ, Ctr Cellular Therapy, Affiliated Hosp 2, Nanjing, Jiangsu, Peoples R China.
   [Ren, Wei; Guo, Jianjin] Shanghai Jiao Tong Univ, Dept Endocrinol & Metab, Affiliated Peoples Hosp 6, Shanghai Diabet Inst, Shanghai 200030, Peoples R China.
   [Ren, Wei; Guo, Jianjin] Shanghai Clin Ctr Diabet, Shanghai, Peoples R China.
   [Wan, Meng] Nanjing Med Univ, Nanjing Hosp 1, Dept Pharm, Nanjing, Jiangsu, Peoples R China.
C3 Nanjing Medical University; Nanjing Medical University; Shanghai Jiao
   Tong University; Nanjing Medical University
RP Su, DM (corresponding author), Nanjing Med Univ, Ctr Metab Dis Res, Nanjing, Jiangsu, Peoples R China.
EM sudongming@njmu.edu.cn
RI Shen, Yachen/HGE-6370-2022; Ren, Wei/F-2777-2012
OI Shen, Yachen/0000-0003-2614-3387
FU National Basic Research Program of China [2011CB504000]; National
   Natural Science Foundation of China [81070656, 81171589]
FX Funding from the National Basic Research Program of China (2011CB504000,
   973 Program) and the National Natural Science Foundation of China
   (81070656, 81171589). The funders had no role in study design, data
   collection and analysis, decision to publish, or preparation of the
   manuscript.
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NR 47
TC 78
Z9 84
U1 0
U2 25
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD OCT 25
PY 2013
VL 8
IS 10
AR e78284
DI 10.1371/journal.pone.0078284
PG 12
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 241GW
UT WOS:000326155400075
PM 24205181
OA gold, Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Silva, MAAE
   Vechetti, IJ Jr
   do Nascimento, AF
   Furtado, KS
   Azevedo, L
   Ribeiro, DA
   Barbisan, LF
AF Aguiar e Silva, Marco Aurelio
   Vechetti-Junior, Ivan Jose
   do Nascimento, Andre Ferreira
   Furtado, Kelly Silva
   Azevedo, Luciana
   Ribeiro, Daniel Araki
   Barbisan, Luis Fernando
TI Effects of swim training on liver carcinogenesis in male Wistar rats fed
   a low-fat or high-fat diet
SO APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
LA English
DT Article
DE swim training; rat liver carcinogenesis; high-fat diet;
   preneoplastic-neoplastic lesions
ID HEPATOCELLULAR-CARCINOMA; OXIDATIVE STRESS; PHYSICAL-ACTIVITY;
   NONALCOHOLIC STEATOHEPATITIS; PRENEOPLASTIC LESIONS; CELL-PROLIFERATION;
   METABOLIC SYNDROME; EXERCISE; CANCER; APOPTOSIS
AB The present study aimed to investigate the beneficial effects of swim training on the promotion-progression stages of rat liver carcinogenesis. Male Wistar rats were submitted to chemically induced liver carcinogenesis and allocated into 4 major groups, according their dietary regimen (16 weeks) and swim training of 5 days per week (8 weeks): 2 groups were fed low-fat diet (LFD, 6% fat) and trained or not trained and 2 groups were fed high-fat diet (HFD, 21% fat) and trained or not trained. At week 20, the animals were killed and liver samples were processed for histological analyses; immunohistochemical detection of persistent or remodeling preneoplastic lesions (pPNL and rPNL) expressing placental glutathione S-transferase (GST-P) enzyme; or proliferating cell nuclear antigen (PCNA), cleaved caspase-3, and bcl-2 protein levels by Western blotting or malonaldehyde (MDA) and total glutathione detection by HPLC. Overall analysis indicated that swim training reduced the body weight and body fat in both LFD and HFD groups, normalized total cholesterol levels in the HFD group while decreased the MDA levels, increased glutathione levels and both number of GST-P-positive pPNL and hepatocellular adenomas in LFD group. Also, a favorable balance in PCNA, cleaved caspase-3, and bcl-2 levels was detected in the liver from the LFD-trained group in relation to LFD-untrained group. The findings of this study indicate that the swim training protocol as a result of exercise postconditioning may attenuate liver carcinogenesis under an adequate dietary regimen with lowered fat intake.
C1 [Barbisan, Luis Fernando] Sao Paulo State Univ, UNESP, Inst Biosci, Dept Morphol, BR-18618970 Botucatu, SP, Brazil.
   [Aguiar e Silva, Marco Aurelio; Vechetti-Junior, Ivan Jose] Sao Paulo State Univ, UNESP, Inst Biosci, Postgrad Program Gen & Appl Biol, BR-18618970 Botucatu, SP, Brazil.
   [do Nascimento, Andre Ferreira] Sao Paulo State Univ, UNESP, Sch Med, Dept Clin Med, BR-18618970 Botucatu, SP, Brazil.
   [Furtado, Kelly Silva] Sao Paulo State Univ, UNESP, Sch Med, Dept Pathol, BR-18618970 Botucatu, SP, Brazil.
   [Azevedo, Luciana] Univ Fed Alfenas, UNIFAL, Fac Nutr, BR-37130000 Alfenas, MG, Brazil.
   [Ribeiro, Daniel Araki] Univ Fed Sao Paulo, UNIFESP, Dept Biosci, BR-11060001 Santos, SP, Brazil.
C3 Universidade Estadual Paulista; Universidade Estadual Paulista;
   Universidade Estadual Paulista; Universidade Estadual Paulista;
   Universidade Federal de Alfenas; Universidade Federal de Sao Paulo
   (UNIFESP)
RP Barbisan, LF (corresponding author), Sao Paulo State Univ, UNESP, Inst Biosci, Dept Morphol, BR-18618970 Botucatu, SP, Brazil.
EM barbisan@ibb.unesp.br
RI Vechetti, Ivan/C-5406-2012; Ribeiro, Daniel/B-4645-2017; dos Santos
   Silva, Marco/D-3468-2017; Azevedo, Luciana/C-9279-2013; Furtado,
   Kelly/I-1050-2013; Barbisan, Luis/AAX-8402-2021; Nascimento,
   Andre/AAN-7191-2020
OI Barbisan, Luis Fernando/0000-0002-2180-1814; Vechetti,
   Ivan/0000-0003-1024-1011; Ribeiro, Daniel Araki/0000-0001-5057-4983;
   Azevedo, Luciana/0000-0002-0502-4090
FU Fundacao para o Desenvolvimento da UNESP [FUNDUNESP DFP- 0028610];
   FAPESP [2010/03056-9]; CNPq [301585/2009-1]; Fundacao de Amparo a
   Pesquisa do Estado de Sao Paulo (FAPESP) [10/03056-9] Funding Source:
   FAPESP
FX The study was supported by Fundacao para o Desenvolvimento da UNESP
   (FUNDUNESP DFP- 0028610). Marco A. Aguiar e Silva and Luis F Barbisan
   were recipients of fellowships from FAPESP (2010/03056-9) and CNPq
   (301585/2009-1), respectively.
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NR 51
TC 11
Z9 14
U1 0
U2 4
PU CANADIAN SCIENCE PUBLISHING
PI OTTAWA
PA 123 Slater Street, Suite 610, OTTAWA, ON K1P 5H2, CANADA
SN 1715-5312
EI 1715-5320
J9 APPL PHYSIOL NUTR ME
JI Appl. Physiol. Nutr. Metab.
PD DEC
PY 2012
VL 37
IS 6
BP 1101
EP 1109
DI 10.1139/H2012-129
PG 9
WC Nutrition & Dietetics; Physiology; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics; Physiology; Sport Sciences
GA 042PR
UT WOS:000311483800010
PM 22957766
DA 2025-06-11
ER

PT J
AU Nakagawa, Y
   Kishida, K
   Funahashi, T
   Yanagi, K
   Shimomura, I
AF Nakagawa, Yasuhiko
   Kishida, Ken
   Funahashi, Tohru
   Yanagi, Koji
   Shimomura, Iichiro
TI Coexistence of Visceral Fat Accumulation and Sleep-Disordered Breathing
   Correlates with Coronary Artery Disease
SO JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
LA English
DT Article
DE Coronary artery disease; Visceral fat accumulation; Sleep-disordered
   breathing; Adiponectin
ID C-REACTIVE PROTEIN; CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME;
   INSULIN-RESISTANCE; ABDOMINAL OBESITY; APNEA-HYPOPNEA; RISK-FACTORS;
   DEFINITION; HYPOXIA; STRESS
AB Aim: Visceral adiposity is linked with sleep-disordered breathing (SDB) (called Syndrome Z), and both correlate with coronary artery disease (CAD). The aim of the present study was to determine the significance of excess visceral fat, SDB and circulating levels of biomarkers in CAD in Japanese men.
   Methods: SDB, visceral fat area (VFA), and circulating levels of biomarkers were assessed in 60 Japanese male patients who underwent coronary angiography and overnight cardiorespiratory monitoring.
   Results: Age-adjusted logistic analysis showed a significant relationship between CAD and diabetes, hypertension, dyslipidemia, SDB (AHI >= 5 events/hour), visceral fat accumulation (VFA >= 100 cm(2)), the combination of visceral fat accumulation and hypertension or dyslipidemia, as well as the combination of visceral fat accumulation and SDB. Patients with VFA >= 100 cm(2) and SDB had significantly lower serum adiponectin levels and higher serum soluble CD40 ligand levels than those with VFA <100 cm(2) and SDB. The prevalence of CAD was significantly higher in patients with VFA >= 100 cm(2) and SDB than in patients with VFA < 100 cm(2) and AHI < 5 events/hour, patients with VFA < 100 cm(2) and AHI >= 5 events/hour or patients with VFA >= 100 cm(2) and AHI < 5 events/hour (93% versus 14%, p < 0.001, 53%, p < 0.01 or 63%, p < 0.01, respectively).
   Conclusions: The present study indicates that patients with both visceral fat accumulation and SDB develop CAD in association with hypoadiponectinemia and inflammatory activity.
C1 [Kishida, Ken; Funahashi, Tohru] Osaka Univ, Dept Metab & Atherosclerosis, Grad Sch Med, Suita, Osaka 5650871, Japan.
   [Nakagawa, Yasuhiko; Kishida, Ken; Funahashi, Tohru; Shimomura, Iichiro] Osaka Univ, Dept Metab Med, Grad Sch Med, Suita, Osaka 5650871, Japan.
   [Yanagi, Koji] Kenporen Osaka Cent Hosp, Dept Cardiol, Osaka, Japan.
C3 The University of Osaka; The University of Osaka
RP Kishida, K (corresponding author), Osaka Univ, Dept Metab & Atherosclerosis, Grad Sch Med, 2-2 B-5 Yamada Oka, Suita, Osaka 5650871, Japan.
EM kkishida@imed2.med.osaka-u.ac.jp
FU Kowa Co. Ltd.;  [21591177];  [22126008]
FX We are grateful to Drs. Munetaka Nishio, Chisa Nakagawa, and Yoshiharu
   Nishida for patient enrollment, and Mr. Masato Tanaka and Mr. Hitoshi
   Ogawa for the excellent technical assistance and sleep-study scoring. We
   also thank the staff of Kenporen Osaka Central Hospital for technical
   assistance. This research was supported in part by a Grant-in-Aid for
   Scientific Research No. (C) 21591177 (to K.K.) and a Grant-in-Aid for
   Scientific Research on Innovative Areas (Research in a proposed research
   area) "Molecular Basis and Disorders of Control of Appetite and Fat
   Accumulation" (# 22126008, to T.F. and K.K.).Ken Kishida and Tohru
   Funahashi are members of the "Department of Metabolism and
   Atherosclerosis," a sponsored course endowed by Kowa Co. Ltd. and a
   company researcher is dispatched to the course. All other authors
   declare no competing interests.
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NR 26
TC 5
Z9 5
U1 0
U2 1
PU JAPAN ATHEROSCLEROSIS SOC
PI TOKYO
PA NICHINAI-KAIKAN B1, 3-28-8 HONGO BUNKYO-KU, TOKYO, 113-0033, JAPAN
SN 1340-3478
EI 1880-3873
J9 J ATHEROSCLER THROMB
JI J. Atheroscler. Thromb.
PY 2012
VL 19
IS 8
BP 728
EP 735
PG 8
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 001CM
UT WOS:000308437400005
PM 22572611
DA 2025-06-11
ER

PT J
AU Jun, DW
   Cho, WK
   Jun, JH
   Kwon, HJ
   Jang, KS
   Kim, HJ
   Jeon, HJ
   Lee, KN
   Lee, HL
   Lee, OY
   Yoon, BC
   Choi, HS
   Hahm, JS
   Lee, MH
AF Jun, Dae Won
   Cho, Won Kyeong
   Jun, Jin Hyun
   Kwon, Hyuk Jin
   Jang, Ki-Seok
   Kim, Hyun-Jeong
   Jeon, Hye Jun
   Lee, Kang Nyeong
   Lee, Hang Lak
   Lee, Oh Young
   Yoon, Byung Chul
   Choi, Ho Soon
   Hahm, Joon Soo
   Lee, Min Ho
TI Prevention of free fatty acid-induced hepatic lipotoxicity by carnitine
   via reversal of mitochondrial dysfunction
SO LIVER INTERNATIONAL
LA English
DT Article
DE carnitine; lipotoxicity; mitochondria
ID INSULIN-RESISTANCE; NONALCOHOLIC STEATOHEPATITIS; METABOLIC SYNDROME;
   BETA-OXIDATION; LIVER-DISEASE; DNA CONTENT; NASH; SUPPLEMENTATION;
   THERAPY; FATIGUE
AB Background: Mitochondria are the main sites for fatty acid oxidation and play a central role in lipotoxicity and nonalcoholic steatohepatitis. Aims: We investigated whether carnitine prevents free fatty acid (FFA)-induced lipotoxicity in vitro and in vivo. Methods: HepG2 cells were incubated with FFA, along with carnitine and carnitine complexes. Mitochondrial beta-oxidation, transmembrane potential, intracellular ATP levels and changes in mitochondrial copy number and morphology were analysed. Otsuka Long-Evans Tokushima Fatty and Long-Evans Tokushima Otsuka rats were segregated into three experimental groups and fed for 8 weeks with (i) normal chow, (ii) a methionine choline-deficient (MCD) diet or (iii) an L-carnitine-supplemented MCD diet. Results: Carnitine prevented FFA-induced apoptosis (16% vs. 3%, P < 0.05). FFA treatment resulted in swollen mitochondria with increased inner matrix density and loss of cristae. However, mitochondria co-treated with carnitine had normal ultrastructure. The mitochondrial DNA copy number was higher in the carnitine treatment group than in the palmitic acid treatment group (375 vs. 221 copies, P < 0.05). The carnitine group showed higher mitochondrial beta-oxidation than did the control and palmitic acid treatment groups (597 vs. 432 and 395 ccpm, P < 0.05). Carnitine treatment increased the mRNA expression of carnitine palmitoyltransferase 1A and peroxisome proliferator-activated receptor-gamma, and carnitine-lipoic acid further augmented the mRNA expression. In the in vivo model, carnitine-treated rats showed lower alanine transaminase levels and lesser lobular inflammation than did the MCD-treated rats. Conclusions: Carnitine and carnitine-lipoic acid prevent lipotoxicity by increasing mitochondrial beta-oxidation and reducing intracellular oxidative stress.
C1 [Jun, Dae Won; Jeon, Hye Jun; Lee, Kang Nyeong; Lee, Hang Lak; Lee, Oh Young; Yoon, Byung Chul; Choi, Ho Soon; Hahm, Joon Soo; Lee, Min Ho] Hanyang Univ, Sch Med, Dept Internal Med, Seoul 133792, South Korea.
   [Cho, Won Kyeong; Kwon, Hyuk Jin] Celltr Pharma, Seoul, South Korea.
   [Jun, Jin Hyun] Eulji Univ, Coll Hlth Sci, Dept Biomed Lab Sci, Songnam, South Korea.
   [Jang, Ki-Seok; Kim, Hyun-Jeong] Hanyang Univ, Sch Med, Dept Pathol, Seoul 133792, South Korea.
C3 Hanyang University; Eulji University; Hanyang University
RP Jun, DW (corresponding author), Hanyang Univ, Sch Med, Dept Internal Med, Seoul 133792, South Korea.
EM noshin@hanyang.ac.kr
RI Jun, Dae Won/O-4529-2017; Lee, Yoojin/AAB-9799-2022; Lee,
   Jee-Yon/GER-4141-2022; Jang, Kiseok/P-2048-2015
OI Lee, Kang Nyeong/0000-0002-3728-8672
FU Bio-Meditech Regional Innovation Center at Eulji University, under the
   Regional Innovation Center Program of the Ministry of Commerce, Industry
   and Energy
FX This work was supported by the Bio-Meditech Regional Innovation Center
   at Eulji University, under the Regional Innovation Center Program of the
   Ministry of Commerce, Industry and Energy.
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NR 28
TC 47
Z9 52
U1 0
U2 22
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1478-3223
EI 1478-3231
J9 LIVER INT
JI Liver Int.
PD OCT
PY 2011
VL 31
IS 9
BP 1315
EP 1324
DI 10.1111/j.1478-3231.2011.02602.x
PG 10
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 819JZ
UT WOS:000294822500009
PM 22093454
OA Bronze
DA 2025-06-11
ER

PT J
AU Sivasankaran, S
AF Sivasankaran, S.
TI The cardio-protective diet
SO INDIAN JOURNAL OF MEDICAL RESEARCH
LA English
DT Review
DE Adiposopathy; beta cell protection; cardiovascular diseases; eating
   behavior; prudent diet; sarcopenic adiposity
ID CORONARY-HEART-DISEASE; ALPHA-LINOLENIC ACID; CARDIOVASCULAR-DISEASE;
   METABOLIC SYNDROME; ABDOMINAL OBESITY; RISK-FACTORS; LIFE-STYLE;
   PREVENTION; HEALTH; FOOD
AB Globalization has made calorie rich, cheap, convenient marketed foods the main menu for the common man. Indians are particularly susceptible to the adverse outcomes of this dietary change because of ethnic, epigenetic reasons and sarcopenic adiposity (less muscle more fat for the same body weight). Children have smaller body frame making them more susceptible to adverse effects of hyperglycaemia leading to stress on beta cells and their damage. This has resulted in escalation of lifestyle diseases by three-fold, that too at our younger age group at lower body mass indices. Preventive measures are necessary in early life to protect the beta cells, to achieve a metabolically healthy society. This will help in sustaining optimal beta cell function throughout a person's life. Modification in dietary habits by educating the society, proper food labelling and legal regulation, restricting calorie, sugar, saturated fat, trans-fat and salt intake has proved its benefits in the developed world. Changes in the quality of food is as important as restricting calorie intake. This includes facilitation of increased consumption of dietary fiber, complex carbohydrates, nuts, fruits and vegetables. Restrictions are needed to reduce trans-fats, saturated fats and cooking habits such as deep frying which oxidizes cholesterol and lipids. Foods with long shelf-life shorten the life line because of their salt, sugar or trans-fat content. Individual meals need to be targeted in the general dietary guidelines, to minimize the post-prandial metabolic insult. In general, we need healthy start to early life particularly the first twenty years of life so that the habits cultured during childhood are sustained for the rest of productive years.
C1 Sree Chitra Tirunal Inst Med Sci & Technol, Dept Cardiol, Thiruvananthapuram 695008, Kerala, India.
C3 Department of Science & Technology (India); Sree Chitra Tirunal
   Institute for Medical Sciences Technology (SCTIMST)
RP Sivasankaran, S (corresponding author), Sree Chitra Tirunal Inst Med Sci & Technol, Dept Cardiol, Thiruvananthapuram 695008, Kerala, India.
EM sivasct@hotmail.com
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NR 110
TC 22
Z9 24
U1 1
U2 30
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, 400059, INDIA
SN 0971-5916
J9 INDIAN J MED RES
JI Indian J. Med. Res.
PD NOV
PY 2010
VL 132
IS 5
BP 608
EP 616
PG 9
WC Immunology; Medicine, General & Internal; Medicine, Research &
   Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; General & Internal Medicine; Research & Experimental
   Medicine
GA 690UE
UT WOS:000285033100021
PM 21150013
DA 2025-06-11
ER

PT J
AU Carbonelli, MG
   Di Renzo, L
   Bigioni, M
   Di Daniele, N
   De Lorenzo, A
   Fusco, MA
AF Carbonelli, M. G.
   Di Renzo, L.
   Bigioni, M.
   Di Daniele, N.
   De Lorenzo, A.
   Fusco, M. A.
TI α-Lipoic Acid Supplementation: A Tool for Obesity Therapy?
SO CURRENT PHARMACEUTICAL DESIGN
LA English
DT Review
DE alpha-lipoic acid; obesity; LA/DHLA; BMI; body composition
ID METABOLIC SYNDROME; INSULIN-RESISTANCE; ENDOTHELIAL DYSFUNCTION; INDUCED
   HYPERTENSION; BLOOD-PRESSURE; PROTEIN; INFLAMMATION; DISEASE;
   SENSITIVITY; PREVENTION
AB Lipid peroxidation is believed to be the major biochemical alteration underling oxidant-induced cell injury in stress including numerous diseases. One of the natural molecules known to prevent or retardate oxidation is alpha-lipoic acid (alpha-LA) thus, the lipoic acid/dihydrolipoic acid (LA/DHLA) redox couple has received considerable attention. Recent studies highlighted the potential of free LA and DHLA as powerful metabolic antioxidants that are able to scavenge the reactive oxygen species and to recycle other antioxidants. Our aim was to investigate the effects of alpha-LA in the treatment of Italian pre-obese and obese patients.
   1612 people were enrolled and 1127 of them (445 men and 682 women, 18-60 age) met criteria and were screened in the study. According to body mass index (BMI), 53% of them were obese, and 43% were pre-obese. They were treated for 4 months with 800 mg/day of alpha-LA. In the pre-obese group, significant reductions (p<0.001) of weight (8%, in both gender), BMI (2 points), blood pressure, and abdominal circumference (female 6 cm, male 7 cm) were observed. In the obese group, significant reductions (p<0.001) of weight (9%, in both gender), BMI (female 3 point, male 4 point), blood pressure and abdominal circumference (female 9 cm, male 11 cm) were highlighted.
   Our study indicated that alpha-LA is an ideal antioxidant candidate for the therapy of obesity related diseases. Further clinical studies should be considered to demonstrate the role and efficacy of alpha-LA treatment.
C1 [Di Renzo, L.; Bigioni, M.; De Lorenzo, A.] Univ Roma Tor Vergata, Dept Neurosci, Div Human Nutr, I-00133 Rome, Italy.
   [Carbonelli, M. G.; Fusco, M. A.] Azienda Osped San Camillo Forlanini, Rome, Italy.
   [Di Daniele, N.] Univ Roma Tor Vergata, Dept Internal Med, I-00133 Rome, Italy.
C3 University of Rome Tor Vergata; Azienda Ospedaliera San
   Camillo-Forlanini; University of Rome Tor Vergata
RP De Lorenzo, A (corresponding author), Univ Roma Tor Vergata, Dept Neurosci, Div Human Nutr, Via Montpellier 1, I-00133 Rome, Italy.
EM delorenzo@uniroma2.it
RI Di Renzo, Laura/ACB-2003-2022
OI di renzo, laura/0000-0001-8875-6723
FU Istituto Nazionale per la Dieta Mediterranea e la Nutrigenomica
   (I.N.DI.M)
FX This study was supported by grant from Istituto Nazionale per la Dieta
   Mediterranea e la Nutrigenomica (I.N.DI.M). The authors thank
   Segix-Italia, (Pomezia, Rome, Italy) for providing the lipoic acid
   (Liponax). The authors have no financial or personal interests in any
   organization sponsoring the research at the time the research was done.
   The authors thank Steve Otuoke, MD, and Alessia Bianchi for critical
   reading of this manuscript.
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NR 45
TC 59
Z9 63
U1 0
U2 13
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1381-6128
EI 1873-4286
J9 CURR PHARM DESIGN
JI Curr. Pharm. Design
PD MAR
PY 2010
VL 16
IS 7
BP 840
EP 846
DI 10.2174/138161210790883589
PG 7
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 556CG
UT WOS:000274564600012
PM 20388095
DA 2025-06-11
ER

PT J
AU Henkel, AS
   Elias, MS
   Green, RM
AF Henkel, Anne S.
   Elias, Marc S.
   Green, Richard M.
TI Homocysteine Supplementation Attenuates the Unfolded Protein Response in
   a Murine Nutritional Model of Steatohepatitis
SO JOURNAL OF BIOLOGICAL CHEMISTRY
LA English
DT Article
ID ENDOPLASMIC-RETICULUM STRESS; CYSTATHIONINE BETA-SYNTHASE; NONALCOHOLIC
   FATTY LIVER; ADENOSYL-L-METHIONINE; S-ADENOSYLMETHIONINE;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; SIGNALING PATHWAY;
   VASCULAR-DISEASE; HEPG2 CELLS
AB Hyperhomocysteinemia has been correlated with hepatic steatosis and activation of the unfolded protein response (UPR), yet a causal relationship has not been established. Although methionine and choline are essential components of homocysteine metabolism, the role of homocysteine in the pathogenesis of a methionine- and choline-deficient (MCD) diet remains unknown. We explored the effects of homocysteine supplementation on hepatic steatosis and the UPR in mice fed a control or MCD diet. Mice fed the MCD diet developed severe hyperhomocysteinemia and activation of the hepatic UPR. Supplementing the MCD diet with homocysteine attenuated the MCD diet-induced hepatic UPR activation and other injurious effects of the MCD diet including hepatic cholesterol accumulation, weight loss, and plasma ALT elevation. Homocysteine supplementation replenished the MCD diet-induced depletion of hepatic S-adenosylmethionine (SAM). Depleting SAM in HepG2 cells using MAT1 alpha siRNA or cycloleucine resulted in enhanced activation of the UPR upon exposure to thapsigargin. Mice fed a control diet supplemented with homocysteine had a 3-fold elevation in plasma homocysteine level by 2 weeks and 6-fold elevation by 6 weeks but demonstrated no other pathophysiologic change. In summary, we found that homocysteine attenuates MCD diet-induced hepatic UPR activation, likely via repletion of hepatic SAM. Furthermore, homocysteine supplementation alone does not cause hepatic steatosis or UPR activation despite inducing hyperhomocysteinemia. These studies indicate that although hyperhomocysteinemia is often associated with hepatic steatosis and UPR activation, these effects may be a secondary response rather than a direct effect of homocysteine.
C1 [Henkel, Anne S.; Elias, Marc S.; Green, Richard M.] Northwestern Univ, Feinberg Sch Med, Dept Med, Div Hepatol, Chicago, IL 60611 USA.
C3 Northwestern University; Feinberg School of Medicine
RP Henkel, AS (corresponding author), 303 E Chicago Ave,Searle 10-541, Chicago, IL 60611 USA.
EM a-henkel2@md.northwestern.edu
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NR 35
TC 32
Z9 36
U1 0
U2 7
PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3996 USA
EI 1083-351X
J9 J BIOL CHEM
JI J. Biol. Chem.
PD NOV 13
PY 2009
VL 284
IS 46
BP 31807
EP 31816
DI 10.1074/jbc.M109.017970
PG 10
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 516VZ
UT WOS:000271572700035
OA Green Published
DA 2025-06-11
ER

PT J
AU Nijhuis, J
   Rensen, SS
   Slaats, Y
   van Dielen, FMH
   Buurman, WA
   Greve, JWA
AF Nijhuis, Jeroen
   Rensen, Sander S.
   Slaats, Yanti
   van Dielen, Francois M. H.
   Buurman, Wim A.
   Greve, Jan Willem A.
TI Neutrophil Activation in Morbid Obesity, Chronic Activation of Acute
   Inflammation
SO OBESITY
LA English
DT Article
ID INDUCED WEIGHT-LOSS; INSULIN-RESISTANCE; CARDIOVASCULAR-DISEASE;
   METABOLIC SYNDROME; OXIDATIVE STRESS; MYELOPEROXIDASE; MICE; IMPAIRMENT;
   PROTEINS; EXERCISE
AB Recent studies show that morbid obesity is associated with activation of the innate immune response. Neutrophil activation is a fundamental process in the innate immune response. Therefore, the activation state of neutrophils in severely obese subjects and the effect of bariatric surgery on neutrophil activation was evaluated. Neutrophil activation was assessed by measuring circulating concentrations of myeloperoxidase (MPO) and calprotectin in 37 severely obese and 9 control subjects (enzyme-linked immunosorbent assay). Moreover, membrane expression of CD66b on circulating neutrophils was measured using flow cytometry in a group of seven severely obese and six control subjects. Immunohistochemical detection of MPO was performed in adipose and muscle tissue. Plasma MPO and calprotectin levels were significantly increased in severely obese subjects as compared to healthy controls, 27.1 +/- 10.8 vs. 17.3 +/- 5.5 ng/ml (P < 0.001) and 115.5 +/- 43.5 vs. 65.1 +/- 23.1 ng/ml (P < 0.001) for MPO and calprotectin, respectively. In line, CD66b expression was significantly increased in severely obese individuals, 177.3 +/- 43.7 vs. 129.7 +/- 9.2 (mean fluorescence intensity) (P < 0.01). Bariatric surgery resulted in decreased calprotectin, but MPO plasma levels remained elevated. Adipose and muscle tissue did not contain increased numbers of MPO expressing cells in severely obese individuals. These results point out that circulating neutrophils are activated to a greater extent in severely obese subjects. Our data support the finding that the innate immune system is activated in severely obese individuals. Moreover, because neutrophils have a short life span, this indicates that the chronic inflammatory condition associated with morbid obesity is characterized by a continuous activation of the innate immune system.
C1 [Nijhuis, Jeroen; Rensen, Sander S.; Slaats, Yanti; van Dielen, Francois M. H.; Buurman, Wim A.; Greve, Jan Willem A.] Maastricht Univ, NUTRIM, Dept Gen Surg, Med Ctr, Maastricht, Netherlands.
C3 Maastricht University
RP Rensen, SS (corresponding author), Maastricht Univ, NUTRIM, Dept Gen Surg, Med Ctr, Maastricht, Netherlands.
RI Greve, Jan Willem/MCJ-5299-2025; Rensen, Sander/J-3224-2019
OI Rensen, Sander/0000-0001-5054-8400
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NR 26
TC 188
Z9 211
U1 0
U2 14
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1930-7381
EI 1930-739X
J9 OBESITY
JI Obesity
PD NOV
PY 2009
VL 17
IS 11
BP 2014
EP 2018
DI 10.1038/oby.2009.113
PG 5
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 512HT
UT WOS:000271237700009
PM 19390527
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Hauser, J
   Knapman, A
   Zürcher, NR
   Pilloud, S
   Maier, C
   Diaz-Heijtz, R
   Forssberg, H
   Dettling, A
   Feldon, J
   Pryce, CR
AF Hauser, Jonas
   Knapman, Alana
   Zuercher, Nicole R.
   Pilloud, Sonia
   Maier, Claudia
   Diaz-Heijtz, Rochellys
   Forssberg, Hans
   Dettling, Andrea
   Feldon, Joram
   Pryce, Christopher R.
TI Effects of Prenatal Dexamethasone Treatment on Physical Growth,
   Pituitary-Adrenal Hormones, and Performance of Motor, Motivational, and
   Cognitive Tasks in Juvenile and Adolescent Common Marmoset Monkeys
SO ENDOCRINOLOGY
LA English
DT Article
ID RESPIRATORY-DISTRESS-SYNDROME; ANTENATAL CORTICOSTEROIDS; EARLY
   DEPRIVATION; BRAIN-DAMAGE; RAT; STRESS; EXPOSURE; ENDOCRINE; RECEPTOR;
   CORTEX
AB Synthetic glucocorticoids such as dexamethasone (DEX) are commonly used to prevent respiratory distress syndrome in preterm infants, but there is emerging evidence of subsequent neurobehavioral abnormalities ( e. g. problems with inattention/ hyperactivity). In the present study, we exposed pregnant common marmosets ( Callithrix jacchus, primates) to daily repeated DEX ( 5 mg/kg by mouth) during either early (d 42-48) or late ( d 90-96) pregnancy ( gestation period of 144 days). Relative to control, and with a longitudinal design, we investigated DEX effects in offspring in terms of physical growth, plasma ACTH and cortisol titers, social and maintenance behaviors, skilled motor reaching, motivation for palatable reward, and learning between infancy and adolescence. Early DEX resulted in reduced sociability in infants and increased motivation for palatable reward in adolescents. Late DEX resulted in a mild transient increase in knee-heel length in infants and enhanced reversal learning of stimulus-reward association in adolescents. There was no effect of either early or late DEX on basal plasma ACTH or cortisol titers. Both treatments resulted in impaired skilled motor reaching in juveniles, which attenuated in early DEX but persisted in late DEX across test sessions. The increased palatable-reward motivation and decreased social motivation observed in early DEX subjects provide experimental support for the clinical reports that prenatal glucocorticoid treatment impairs social development and predisposes to metabolic syndrome. These novel primate findings indicate that fetal glucocorticoid overexposure can lead to abnormal development of motor, affective, and cognitive behaviors. Importantly, the outcome is highly dependent upon the timing of glucocorticoid overexposure. ( Endocrinology 149: 6343-6355, 2008)
C1 [Hauser, Jonas; Knapman, Alana; Zuercher, Nicole R.; Pilloud, Sonia; Maier, Claudia; Dettling, Andrea; Feldon, Joram; Pryce, Christopher R.] Swiss Fed Inst Technol Zurich, Behav Neurobiol Lab, CH-8603 Schwerzenbach, Switzerland.
   [Diaz-Heijtz, Rochellys] Karolinska Inst, Behav Neurosci Lab, S-17177 Stockholm, Sweden.
   [Forssberg, Hans] Astrid Lindgren Childrens Hosp, Karolinska Inst, S-17176 Stockholm, Sweden.
C3 Swiss Federal Institutes of Technology Domain; ETH Zurich; Karolinska
   Institutet; Karolinska Institutet
RP Feldon, J (corresponding author), Swiss Fed Inst Technol Zurich, Behav Neurobiol Lab, Schorenstr 16, CH-8603 Schwerzenbach, Switzerland.
EM feldon@behav.biol.ethz.ch; christopher.pryce@novartis.com
RI Zurcher, Nicole/AGF-1440-2022; Forssberg, Hans/A-2944-2009; Hauser,
   Jonas/C-7183-2008; Pryce, Christopher/ABF-9328-2022
OI Hauser, Jonas/0000-0001-7988-5291; Pryce,
   Christopher/0000-0002-5614-4690; Zurcher, Nicole R/0000-0003-0271-6304;
   Forssberg, Hans/0000-0003-2069-6618
FU European Commission Human Potential; Glucocorticoid Hormone Programming
   in Early Life and Its Impact on Adult Health (EUPEAH)
   [QLRI-CT-2002-02758]
FX This work was supported by the European Commission Human Potential
   Program, 5th Framework, Glucocorticoid Hormone Programming in Early Life
   and Its Impact on Adult Health (EUPEAH) Grant No. QLRI-CT-2002-02758.
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NR 69
TC 45
Z9 52
U1 0
U2 11
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0013-7227
EI 1945-7170
J9 ENDOCRINOLOGY
JI Endocrinology
PD DEC
PY 2008
VL 149
IS 12
BP 6343
EP 6355
DI 10.1210/en.2008-0615
PG 13
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 376AX
UT WOS:000261156300049
PM 18755792
DA 2025-06-11
ER

PT J
AU Dongiovanni, P
   Valenti, L
   Fracanzani, AL
   Gatti, S
   Cairo, G
   Fargion, S
AF Dongiovanni, Paola
   Valenti, Luca
   Fracanzani, Anna Ludovica
   Gatti, Stefano
   Cairo, Gaetano
   Fargion, Silvia
TI Iron depletion by deferoxamine up-regulates glucose uptake and insulin
   signaling in hepatoma cells and in rat liver
SO AMERICAN JOURNAL OF PATHOLOGY
LA English
DT Article
ID CARBOHYDRATE-INTOLERANT PATIENTS; INDUCIBLE FACTOR-I; MESSENGER-RNA;
   HEPG2 CELLS; RESISTANCE SYNDROME; METABOLIC SYNDROME; OXIDATIVE STRESS;
   GENE-EXPRESSION; SERUM FERRITIN; RISK-FACTORS
AB Iron depletion improves insulin resistance in patients with nonalcoholic fatty liver disease and diabetes and also stabilizes the hypoxia-inducible factor (HIF)-1 resulting in increased glucose uptake in vitro. This study investigated the effect of iron depletion by deferoxamine on insulin signaling and glucose uptake in HepG2 hepatocytes and in rat liver. In HepG2 cells, deferoxamine stabilized 11117-1 alpha and induced the constitutive glucose transporter Glut1 and the insulin receptor. Up-regulation of insulin receptor by deferoxamine was mimicked by the intraceffular iron chelator deferasirox and the hypoxia inducer CoCl, and required the HIF-1 obligate partner ARNT/HIF-1 beta. iron depletion increased insulin receptor activity, whereas iron supplementation had the opposite effect. Deferoxamine consistently increased the phosphorylation. status of Akt/PKB and its targets FoxO1 and Gsk3 beta., which mediate the effect of insulin on gluconeogenesis and glycogen synthesis, and up-regulated genes involved in glucose uptake and utilization. iron depletion of Sprague-Dawley rats increased 11117-1 alpha expression, improved glucose clearance, and was associated with up-regulation of insulin receptor and Akt/PKB levels and of glucose transport in hepatic tissue. Conversely, gluconeogenic genes were not affected. in rats with fatty liver because of a high-calorie and high-fat diet, glucose clearance was increased by iron depletion and decreased by iron supplementation. Thus, iron depletion by deferoxamine up-regulates glucose uptake, and increases insulin receptor activity and signaling in hepatocytes; in vitro and in vivo.
C1 [Dongiovanni, Paola; Valenti, Luca; Fracanzani, Anna Ludovica; Fargion, Silvia] Univ Milan, Fdn Policlin Mangiagalli & Regina Elena, IRCCS,Ist Rivovero & Cura Carattere Sci, Dept Internal Med,Osped Maggiore Policlin Mangiag, I-20122 Milan, Italy.
   [Gatti, Stefano] Univ Milan, Osped Maggiore Policlin Mangiag, Ist Rivovero & Cura Carattere Sci, Dept Transplantat & Expt Surg, I-20122 Milan, Italy.
   [Cairo, Gaetano] Univ Milan, Dept Gen Pathol, Milan, Italy.
C3 IRCCS Ca Granda Ospedale Maggiore Policlinico; University of Milan;
   University of Milan; IRCCS Ca Granda Ospedale Maggiore Policlinico;
   University of Milan
RP Fargion, S (corresponding author), Univ Milan, Fdn Policlin Mangiagalli & Regina Elena, IRCCS,Ist Rivovero & Cura Carattere Sci, Dept Internal Med,Osped Maggiore Policlin Mangiag, Via F Sforza 35, I-20122 Milan, Italy.
EM silvia.fargion@unimi.it
RI Dongiovanni, Paola/AAC-9965-2019; Valenti, Luca/B-3695-2009; Gatti,
   Stefano/M-1780-2015; Fracanzani, Anna Ludovica/J-8986-2018; Cairo,
   Gaetano/M-5104-2016
OI Valenti, Luca/0000-0001-8909-0345; Gatti, Stefano/0000-0003-2209-4338;
   Dongiovanni, Paola/0000-0003-4343-7213; Fracanzani, Anna
   Ludovica/0000-0001-5918-0171; Cairo, Gaetano/0000-0002-8147-4720
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NR 47
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Z9 153
U1 0
U2 22
PU AMER SOC INVESTIGATIVE PATHOLOGY, INC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3993 USA
SN 0002-9440
J9 AM J PATHOL
JI Am. J. Pathol.
PD MAR
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VL 172
IS 3
BP 738
EP 747
DI 10.2353/ajpath.2008.070097
PG 10
WC Pathology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pathology
GA 268YM
UT WOS:000253616400018
PM 18245813
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Harada, K
   Karube, Y
   Saruhara, H
   Takeda, K
   Kuwajima, I
AF Harada, Kazumasa
   Karube, Yuya
   Saruhara, Hirokazu
   Takeda, Kazuhiro
   Kuwajima, Iwao
TI Workplace hypertension is associated with obesity and family history of
   hypertension
SO HYPERTENSION RESEARCH
LA English
DT Article
DE obesity; job strain; masked hypertension; family history of
   hypertension; health checkup
ID AMBULATORY BLOOD-PRESSURE; JOB STRAIN; METABOLIC SYNDROME;
   CLINICAL-SIGNIFICANCE; PROGNOSTIC VALUE; PREVALENCE; STRESS; MEN;
   HYPERTROPHY; DISEASE
AB Job strain, which is a risk for hypertension and increased left ventricular mass, is thought to cause masked hypertension during work even if blood pressure (BP) is normal at health examinations. To study the prevalence of and factors related to workplace hypertension, 265 public officials (mean age, 41.4 +/- 10.7 years) measured their own BP at their workplace using semiautomated BP measurement devices. Factors related to workplace hypertension were assessed with multiple regression analysis. Workplace hypertension, defined as a BP no less than 140/90 mmHg, was observed in 23% of subjects (n=61). Compared with subjects without workplace hypertension (n=204), subjects with workplace hypertension were older (48.5 +/- 10.0 vs. 393 +/- 10.0 years), more likely to be men (69% vs. 46%), and had a higher body mass index (BMI) (23.4 +/- 2.7 vs. 21.6 +/- 3.2 kg/m(2)), higher cholesterol levels (214 +/- 33 vs. 194 +/- 36 mg/dl), and a higher Brinkman index (134 +/- 228 vs. 59 +/- 148). Subjects with workplace hypertension had higher BPs at checkup than did those without it (125 +/- 11/79 +/- 9 vs. 110 +/- 11/68 +/- 0 mmHg). The increases in BPs at the workplace were independently and significantly correlated with BMI, and a family history of hypertension. BP no less than 130/ 85 mmHg at health checkup was a good detector of workplace hypertension (sensitivity, 49%; specificity, 91%), suggesting that subjects with high-normal BPs at health checkup might have workplace hypertension. In conclusion, workplace hypertension was found to be associated with age, BMI, a family history of hypertension, and high-normal BPs at health checkup.
C1 Tokyo Metropolitan Geriatr Hosp, Fac Med, Div Cardiol, Itabashi Ku, Tokyo 1730015, Japan.
RP Harada, K (corresponding author), Tokyo Metropolitan Geriatr Hosp, Fac Med, Div Cardiol, Itabashi Ku, 35-2 Sakae Cho, Tokyo 1730015, Japan.
EM kharada@tmgh.metro.tokyo.jp
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NR 32
TC 26
Z9 28
U1 0
U2 2
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0916-9636
EI 1348-4214
J9 HYPERTENS RES
JI Hypertens. Res.
PD DEC
PY 2006
VL 29
IS 12
BP 969
EP 976
DI 10.1291/hypres.29.969
PG 8
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 139IX
UT WOS:000244426600007
PM 17378369
OA Bronze
DA 2025-06-11
ER

PT J
AU Agyemang, C
   van der Linden, EL
   Chilunga, F
   van den Born, BJH
AF Agyemang, Charles
   van der Linden, Eva L.
   Chilunga, Felix
   van den Born, Bert-Jan H.
TI International Migration and Cardiovascular Health: Unraveling the
   Disease Burden Among Migrants to North America and Europe
SO JOURNAL OF THE AMERICAN HEART ASSOCIATION
LA English
DT Review
DE cardiovascular disease; ethnic minority groups; Europe; migration;
   review; USA
ID ACUTE MYOCARDIAL-INFARCTION; CAUSE-SPECIFIC MORTALITY;
   CORONARY-HEART-DISEASE; ETHNIC-MINORITY GROUPS; RISK-FACTORS;
   SOCIOECONOMIC INEQUALITIES; MULTIETHNIC COHORT; METABOLIC SYNDROME;
   PHYSICAL-ACTIVITY; WIDE ASSOCIATION
AB Europe and North America are the 2 largest recipients of international migrants from low-resource regions in the world. Here, large differences in cardiovascular disease (CVD) morbidity and death exist between migrants and the host populations. This review discusses the CVD burden and its most important contributors among the largest migrant groups in Europe and North America as well as the consequences of migration to high-income countries on CVD diagnosis and therapy. The available evidence indicates that migrants in Europe and North America generally have a higher CVD risk compared with the host populations. Cardiometabolic, behavioral, and psychosocial factors are important contributors to their increased CVD risk. However, despite these common denominators, there are important ethnic differences in the propensity to develop CVD that relate to pre- and postmigration factors, such as socioeconomic status, cultural factors, lifestyle, psychosocial stress, access to health care and health care usage. Some of these pre- and postmigration environmental factors may interact with genetic (epigenetics) and microbial factors, which further influence their CVD risk. The limited number of prospective cohorts and clinical trials in migrant populations remains an important culprit for better understanding pathophysiological mechanism driving health differences and for developing ethnic-specific CVD risk prediction and care. Only by improved understanding of the complex interaction among human biology, migration-related factors, and sociocultural determinants of health influencing CVD risk will we be able to mitigate these differences and truly make inclusive personalized treatment possible.
C1 [Agyemang, Charles; van der Linden, Eva L.; Chilunga, Felix; van den Born, Bert-Jan H.] Univ Amsterdam, Amsterdam Publ Hlth Res Inst, Dept Publ & Occupat Hlth, Amsterdam UMC, Amsterdam, Netherlands.
   [Agyemang, Charles] Johns Hopkins Univ, Sch Med, Dept Med, Div Endocrinol Diabet & Metab, Baltimore, MD USA.
   [van der Linden, Eva L.; van den Born, Bert-Jan H.] Univ Amsterdam, Dept Vasc Med, Amsterdam UMC, Amsterdam Cardiovasc Sci, Amsterdam, Netherlands.
   [Agyemang, Charles] Univ Amsterdam, Amsterdam Univ Med Ctr, Amsterdam Publ Hlth Res Inst, Dept Publ & Occupat Hlth,Locat AMC, Meibergdreef 15, NL-1105 AZ Amsterdam, Netherlands.
C3 Vrije Universiteit Amsterdam; University of Amsterdam; Johns Hopkins
   University; University of Amsterdam; University of Amsterdam; Vrije
   Universiteit Amsterdam
RP Agyemang, C (corresponding author), Univ Amsterdam, Amsterdam Univ Med Ctr, Amsterdam Publ Hlth Res Inst, Dept Publ & Occupat Hlth,Locat AMC, Meibergdreef 15, NL-1105 AZ Amsterdam, Netherlands.
EM c.o.agyemang@amsterdamumc.nl
RI van der Linden, Eva/AAA-3241-2021; van den Born, Bert-Jan/IUQ-0970-2023
OI van den Born, Bert-Jan H. (BJH)/0000-0003-0943-4393
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NR 147
TC 9
Z9 9
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
EI 2047-9980
J9 J AM HEART ASSOC
JI J. Am. Heart Assoc.
PD MAY 7
PY 2024
VL 13
IS 9
AR e030228
DI 10.1161/JAHA.123.030228
PG 19
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA PO8Q6
UT WOS:001215115900064
PM 38686900
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Siddiq, MA
   Liu, XQ
   Fedorova, T
   Bracken, K
   Virk, S
   Venkatesha, V
   Farivar, A
   Oo, WM
   Linklater, J
   Hill, DC
   Hunter, DJ
AF Siddiq, Md Abu Bakar
   Liu, Xiaoqian
   Fedorova, Tatyana
   Bracken, Karen
   Virk, Sonika
   Venkatesha, Venkatesha
   Farivar, Abdolhay
   Oo, Win Min
   Linklater, James
   Hill, David Cullis
   Hunter, David J.
TI Efficacy and safety of pentosan polysulfate sodium in people with
   symptomatic knee osteoarthritis and dyslipidaemia: protocol of the
   MaRVeL trial
SO BMJ OPEN
LA English
DT Article
DE Clinical Trial; Knee; Osteoarthritis; PAIN MANAGEMENT; Phase II as Topic
ID NONSTEROIDAL ANTIINFLAMMATORY DRUGS; METABOLIC SYNDROME; INFLAMMATION;
   CHOLESTEROL; PAIN; ASSOCIATION; RELIABILITY; COMPONENTS; HEPARIN; STRESS
AB Introduction Knee osteoarthritis (OA) is the most prevalent arthritis type and a leading cause of chronic mobility disability. While pain medications provide only symptomatic pain relief; growing evidence suggests pentosan polysulfate sodium (PPS) is chondroprotective and could have anti-inflammatory effects in knee OA. This study aims to explore the efficacy and safety of oral PPS in symptomatic knee OA with dyslipidaemia.Methods and analysis MaRVeL is a phase II, single-centre, parallel, superiority trial which will be conducted at Royal North Shore Hospital, Sydney, Australia. 92 participants (46 per arm) aged 40 and over with painful knee OA and mild to moderate structural change on X-ray (Kellgren and Lawrence grade 2 or 3) will be recruited from the community and randomly allocated to receive two cycles of either oral PPS or placebo for 5 weeks starting at baseline and week 11. Primary outcome will be the 16-week change in overall average knee pain severity measured using an 11-point Numeric Rating Scale. Main secondary outcomes include change in knee pain, patient global assessment, physical function, quality of life and other structural changes. A biostatistician blinded to allocation groups will perform the statistical analysis according to the intention-to-treat principle.Ethics and dissemination The protocol has been approved by the NSLHD Human Research Ethics Committee (HREC) (2021/ETH00315). All participants will provide written informed consent online. Study results will be disseminated through conferences, social media and academic publications.Trial registration numbers Australian New Zealand Clinical Trial Registry (ACTRN12621000654853); U1111-1265-3750.
C1 [Siddiq, Md Abu Bakar; Liu, Xiaoqian; Virk, Sonika; Farivar, Abdolhay; Hunter, David J.] Univ Sydney, Royal North Shore Hosp, Northern Clin Sch, Dept Rheumatol,Fac Med & Hlth, Sydney, NSW, Australia.
   [Siddiq, Md Abu Bakar; Liu, Xiaoqian; Bracken, Karen; Virk, Sonika; Farivar, Abdolhay; Hunter, David J.] Univ Sydney, Sydney Musculoskeletal Hlth, Sydney, NSW, Australia.
   [Siddiq, Md Abu Bakar; Liu, Xiaoqian; Bracken, Karen; Virk, Sonika; Farivar, Abdolhay; Hunter, David J.] Kolling Inst Med Res, St Leonards, NSW, Australia.
   [Fedorova, Tatyana] Univ Sydney, Fac Med & Hlth, Sydney, NSW, Australia.
   [Bracken, Karen] Univ Sydney, Kolling Inst, Musculoskeletal Hlth, Arabanoo Precinct,Fac Med & Hlth, Sydney, NSW, Australia.
   [Venkatesha, Venkatesha] Royal North Shore Hosp, Rheumatol Dept, St Leonards, NSW, Australia.
   [Oo, Win Min] Kolling Inst Med Res, Rheumatol, St Leonards, NSW, Australia.
   [Oo, Win Min] Univ Med, Mandalay, Mandalay, Myanmar.
   [Linklater, James] Castlereagh Imaging, St Leonards, NSW, Australia.
   [Hill, David Cullis] Arthropharm Pty Ltd, St Leonards, NSW, Australia.
C3 Royal North Shore Hospital; University of Sydney; University of Sydney;
   University of Sydney; Kolling Institute of Medical Research; University
   of Sydney; University of Sydney; Kolling Institute of Medical Research;
   Royal North Shore Hospital; University of Sydney; Kolling Institute of
   Medical Research
RP Siddiq, MA (corresponding author), Univ Sydney, Royal North Shore Hosp, Northern Clin Sch, Dept Rheumatol,Fac Med & Hlth, Sydney, NSW, Australia.; Siddiq, MA (corresponding author), Univ Sydney, Sydney Musculoskeletal Hlth, Sydney, NSW, Australia.; Siddiq, MA (corresponding author), Kolling Inst Med Res, St Leonards, NSW, Australia.
EM msid8426@uni.sydney.edu.au
RI Oo, Win/D-9508-2015; Hunter, David/A-4622-2010
OI Oo, Win Min/0000-0002-4065-7395
FU NHMRC Practitioner Fellowship
FX DJH is supported by an NHMRC Practitioner Fellowship and provides
   consulting advice for Haleon, Novartis, TLC Bio, Tissuegene, Lilly and
   Pfizer.
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NR 46
TC 0
Z9 0
U1 1
U2 3
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2044-6055
J9 BMJ OPEN
JI BMJ Open
PD MAY
PY 2024
VL 14
IS 5
AR e083046
DI 10.1136/bmjopen-2023-083046
PG 11
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA UV3U7
UT WOS:001250806300017
PM 38777590
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Greyling, CF
   Ganguly, A
   Sardesai, AU
   Churcher, NKM
   Lin, KC
   Muthukumar, S
   Prasad, S
AF Greyling, Cornelia Felicia
   Ganguly, Antra
   Sardesai, Abha Umesh
   Churcher, Nathan Kodjo Mintah
   Lin, Kai-Chun
   Muthukumar, Sriram
   Prasad, Shalini
TI Passive sweat wearable: A new paradigm in the wearable landscape toward
   enabling "detect to treat" opportunities
SO WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
LA English
DT Review
DE biosensor; health monitoring; nanomaterial; sweat; wearable sweat-based
   sensor
ID NEUROPEPTIDE-Y; METABOLIC SYNDROME; NEUROIMMUNE BIOMARKERS;
   PLASMA-CORTISOL; STRESS; SENSOR; ACTH; INFLAMMATION; CYTOKINES; DISORDER
AB Growing interest over recent years in personalized health monitoring coupled with the skyrocketing popularity of wearable smart devices has led to the increased relevance of wearable sweat-based sensors for biomarker detection. From optimizing workouts to risk management of cardiovascular diseases and monitoring prediabetes, the ability of sweat sensors to continuously and noninvasively measure biomarkers in real-time has a wide range of applications. Conventional sweat sensors utilize external stimulation of sweat glands to obtain samples, however; this stimulation influences the expression profile of the biomarkers and reduces the accuracy of the detection method. To address this limitation, our laboratory pioneered the development of the passive sweat sensor subfield, which allowed for our progress in developing a sweat chemistry panel. Passive sweat sensors utilize nanoporous structures to confine and detect biomarkers in ultra-low sweat volumes. The ability of passive sweat sensors to use smaller samples than conventional sensors enable users with sedentary lifestyles who perspire less to benefit from sweat sensor technology not previously afforded to them. Herein, the mechanisms and strategies of current sweat sensors are summarized with an emphasis on the emerging subfield of passive sweat-based diagnostics. Prospects for this technology include discovering new biomarkers expressed in sweat and expanding the list of relevant detectable biomarkers. Moreover, the accuracy of biomarker detection can be enhanced with machine learning using prediction algorithms trained on clinical data. Applying this machine learning in conjunction with multiplex biomarker detection will allow for a more holistic approach to trend predictions.This article is categorized under:Diagnostic Tools > Diagnostic NanodevicesNanotechnology Approaches to Biology > Nanoscale Systems in BiologyDiagnostic Tools > Biosensing
C1 [Greyling, Cornelia Felicia; Ganguly, Antra; Churcher, Nathan Kodjo Mintah; Lin, Kai-Chun; Prasad, Shalini] Univ Texas Dallas, Dept Bioengn, 800 W Campbell Rd, Richardson, TX 75080 USA.
   [Sardesai, Abha Umesh] Univ Texas Dallas, Dept Comp Engn, Richardson, TX USA.
   [Muthukumar, Sriram] EnLiSense LLC, Allen, TX USA.
C3 University of Texas System; University of Texas Dallas; University of
   Texas System; University of Texas Dallas
RP Prasad, S (corresponding author), Univ Texas Dallas, Dept Bioengn, 800 W Campbell Rd, Richardson, TX 75080 USA.
EM shalini.prasad@utdallas.edu
RI Ganguly, Antra/LQK-0237-2024
OI Ganguly, Antra/0000-0002-0776-0008
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NR 93
TC 10
Z9 9
U1 20
U2 115
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1939-5116
EI 1939-0041
J9 WIRES NANOMED NANOBI
JI Wiley Interdiscip. Rev.-Nanomed. Nanobiotechnol.
PD JAN
PY 2024
VL 16
IS 1
DI 10.1002/wnan.1912
EA JUN 2023
PG 19
WC Nanoscience & Nanotechnology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics; Research & Experimental Medicine
GA MU2A1
UT WOS:001012995000001
PM 37356818
DA 2025-06-11
ER

PT J
AU Doulberis, M
   Kountouras, J
   Stadler, T
   Meerwein, C
   Polyzos, SA
   Kulaksiz, H
   Chapman, MH
   Rogler, G
   Riva, D
   Linas, I
   Kavaliotis, J
   Kazakos, E
   Mouratidou, M
   Liatsos, C
   Papaefthymiou, A
AF Doulberis, Michael
   Kountouras, Jannis
   Stadler, Thomas
   Meerwein, Christian
   Polyzos, Stergios A.
   Kulaksiz, Hasan
   Chapman, Michael H.
   Rogler, Gerhard
   Riva, Daniele
   Linas, Ioannis
   Kavaliotis, John
   Kazakos, Evangelos
   Mouratidou, Maria
   Liatsos, Christos
   Papaefthymiou, Apostolis
TI Association between Helicobacter pylori Infection and Nasal
   Polyps: A Systematic Review and Meta-Analysis
SO MICROORGANISMS
LA English
DT Review
DE Helicobacter pylori; nasal polyps; chronic rhinosinusitis;
   meta-analysis; association
ID CHRONIC SPONTANEOUS URTICARIA; CHRONIC RHINOSINUSITIS; METABOLIC
   SYNDROME; OXIDATIVE STRESS; FREE-RADICALS; ERADICATION; PREVALENCE;
   PREVENTION; THERAPY; REFLUX
AB Background: Helicobacter pylori (H. pylori) has definite or possible associations with multiple local and distant manifestations. H. pylori has been isolated from multiple sites throughout the body, including the nose. Clinical non-randomized studies with H. pylori report discrepant data regarding the association between H. pylori infection and nasal polyps. The aim of this first systematic review and meta-analysis was the assessment of the strength of the association between H. pylori infection and incidence of nasal polyps. Methods: We performed an electronic search in the three major medical databases, namely PubMed, EMBASE and Cochrane, to extract and analyze data as per PRISMA guidelines. Results: Out of 57 articles, 12 studies were graded as good quality for analysis. Male-to-female ratio was 2:1, and age ranged between 17-78 years. The cumulative pooled rate of H. pylori infection in the nasal polyp group was 32.3% (controls 17.8%). The comparison between the two groups revealed a more significant incidence of H. pylori infection among the nasal polyp group (OR 4.12), though with high heterogeneity I-2 = 66%. Subgroup analysis demonstrated that in European studies, the prevalence of H. pylori infection among the nasal polyp group was significantly higher than in controls, yielding null heterogeneity. Subgroup analysis based on immunohistochemistry resulted in null heterogeneity with preserving a statistically significant difference in H. pylori infection prevalence between the groups. Conclusion: The present study revealed a positive association between H. pylori infection and nasal polyps.
C1 [Doulberis, Michael; Kulaksiz, Hasan] Gastroklin, Private Gastroenterol Practice, CH-8810 Horgen, Switzerland.
   [Doulberis, Michael; Rogler, Gerhard] Univ Hosp Zurich, Dept Gastroenterol, CH-8091 Zurich, Switzerland.
   [Doulberis, Michael] Med Univ Dept, Kantonsspital Aarau, Div Gastroenterol & Hepatol, CH-5001 Aarau, Switzerland.
   [Doulberis, Michael; Kountouras, Jannis; Kavaliotis, John; Kazakos, Evangelos; Mouratidou, Maria] Aristotle Univ Thessaloniki, Ippokrat Hosp, Dept Internal Med, Med Clin 2, Thessaloniki 54642, Greece.
   [Stadler, Thomas; Meerwein, Christian] Univ Hosp Zurich, Dept Otorhinolaryngol Head & Neck Surg, CH-8091 Zurich, Switzerland.
   [Polyzos, Stergios A.] Aristotle Univ Thessaloniki, Sch Med, Lab Pharmacol 1, Thessaloniki 54124, Greece.
   [Chapman, Michael H.; Papaefthymiou, Apostolis] Univ Coll London Hosp UCLH, Pancreaticobiliary Med Unit, London NW1 2BU, England.
   [Riva, Daniele] Gastrocentro Plus, Private Gastroenterol Practice, CH-6900 Lugano, Switzerland.
   [Linas, Ioannis] Gastroenterol Gruppenpraxis, Private Gastroenterol Practice, CH-3011 Bern, Switzerland.
   [Kazakos, Evangelos] Univ West Macedonia, Sch Healthcare Sci, Midwifery Dept, Macedonia 50100, Greece.
   [Liatsos, Christos] 401 Gen Mil Hosp Athens, Dept Gastroenterol, Athens 11525, Attica, Greece.
C3 University of Zurich; University Zurich Hospital; Kantonsspital Aarau AG
   (KSA); Aristotle University of Thessaloniki; University of Zurich;
   University Zurich Hospital; Aristotle University of Thessaloniki;
   University College London Hospitals NHS Foundation Trust
RP Kountouras, J (corresponding author), Aristotle Univ Thessaloniki, Ippokrat Hosp, Dept Internal Med, Med Clin 2, Thessaloniki 54642, Greece.
EM doulberis@gmail.com; jannis@auth.gr; thomas.stadler@usz.ch;
   christian.meerwein@usz.ch; spolyzos@auth.gr; kulaksiz@gastroklinik.ch;
   michael.chapman1@nhs.net; gerhard.rogler@usz.ch;
   daniele.riva@hinmail.ch; ioannis.linas@hin.ch; kavagrc@gmail.com;
   ekazakos@gmail.com; marysia.mouratidou@gmail.com; cliatsos@yahoo.com;
   appapaef@hotmail.com
RI Polyzos, Stergios/H-2844-2019; Rogler, Gerhard/O-5308-2015;
   Papaefthymiou, Apostolis/HPH-4021-2023; Doulberis, Michael/Y-5118-2018
OI LIATSOS, CHRISTOS/0000-0001-8025-0808; Rogler,
   Gerhard/0000-0002-1733-9188; Kazakos, Evangelos/0000-0002-3045-720X;
   Papaefthymiou, Apostolis/0000-0002-3563-4973; Linas,
   Ioannis/0000-0001-9804-2935; Doulberis, Michael/0000-0002-0396-5081
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NR 90
TC 6
Z9 6
U1 0
U2 1
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-2607
J9 MICROORGANISMS
JI Microorganisms
PD JUN
PY 2023
VL 11
IS 6
AR 1581
DI 10.3390/microorganisms11061581
PG 13
WC Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Microbiology
GA K3HM3
UT WOS:001015381600001
PM 37375083
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Higa, Y
   Hiasa, M
   Tenshin, H
   Nakaue, E
   Tanaka, M
   Kim, S
   Nakagawa, M
   Shimizu, S
   Tanimoto, K
   Teramachi, J
   Harada, T
   Oda, A
   Oura, M
   Sogabe, K
   Hara, T
   Sumitani, R
   Maruhashi, T
   Yamagami, H
   Endo, I
   Matsumoto, T
   Tanaka, E
   Abe, M
AF Higa, Yoshiki
   Hiasa, Masahiro
   Tenshin, Hirofumi
   Nakaue, Emiko
   Tanaka, Mariko
   Kim, Sooha
   Nakagawa, Motosumi
   Shimizu, So
   Tanimoto, Kotaro
   Teramachi, Jumpei
   Harada, Takeshi
   Oda, Asuka
   Oura, Masahiro
   Sogabe, Kimiko
   Hara, Tomoyo
   Sumitani, Ryohei
   Maruhashi, Tomoko
   Yamagami, Hiroki
   Endo, Itsuro
   Matsumoto, Toshio
   Tanaka, Eiji
   Abe, Masahiro
TI The Xanthine Oxidase Inhibitor Febuxostat Suppresses Adipogenesis and
   Activates Nrf2
SO ANTIOXIDANTS
LA English
DT Article
DE obesity; adipocytic differentiation; reactive oxygen species (ROS);
   xanthine oxidoreductase (XOR); febuxostat; Nrf2; Keap1
ID METABOLIC SYNDROME; VISCERAL OBESITY; OXIDATIVE STRESS; KEAP1;
   DIFFERENTIATION; DEGRADATION; AUTOPHAGY; INSULIN; IMPACT; ENZYME
AB Xanthine oxidoreductase (XOR) is a rate-limiting enzyme in purine catabolism that acts as a novel regulator of adipogenesis. In pathological states, xanthine oxidoreductase activity increases to produce excess reactive oxygen species (ROS). The nuclear factor erythroid 2-related factor 2 (Nrf2) is a critical inducer of antioxidants, which is bound and repressed by a kelch-like ECH-associated protein 1 (Keap1) in the cytoplasm. The Keap1-Nrf2 axis appears to be a major mechanism for robust inducible antioxidant defenses. Here, we demonstrate that febuxostat, a xanthine oxidase inhibitor, alleviates the increase in adipose tissue mass in obese mouse models with a high-fat diet or ovariectomy. Febuxostat disrupts in vitro adipocytic differentiation in adipogenic media. Adipocytes appeared at day 7 in absence or presence of febuxostat were 160.8 +/- 21.2 vs. 52.5 +/- 12.7 (p < 0.01) in 3T3-L1 cells, and 126.0 +/- 18.7 vs. 55.3 +/- 13.4 (p < 0.01) in 10T1/2 cells, respectively. Adipocyte differentiation was further enhanced by the addition of hydrogen peroxide, which was also suppressed by febuxostat. Interestingly, febuxostat, but not allopurinol (another xanthine oxidase inhibitor), rapidly induced the nuclear translocation of Nrf2 and facilitated the degradation of Keap1, similar to the electrophilic Nrf2 activator omaveloxolone. These results suggest that febuxostat alleviates adipogenesis under oxidative conditions, at least in part by suppressing ROS production and Nrf2 activation. Regulation of adipocytic differentiation by febuxostat is expected to inhibit obesity due to menopause or overeating.
C1 [Higa, Yoshiki; Hiasa, Masahiro; Tenshin, Hirofumi; Nakaue, Emiko; Tanaka, Mariko; Kim, Sooha; Nakagawa, Motosumi; Shimizu, So; Tanimoto, Kotaro; Tanaka, Eiji] Tokushima Univ, Grad Sch Biomed Sci, Dept Orthodont & Dentofacial Orthoped, 3-18-15 Kuramoto, Tokushima 7708503, Japan.
   [Higa, Yoshiki; Harada, Takeshi; Oda, Asuka; Oura, Masahiro; Sogabe, Kimiko; Hara, Tomoyo; Sumitani, Ryohei; Maruhashi, Tomoko; Yamagami, Hiroki; Abe, Masahiro] Tokushima Univ, Grad Sch Biomed Sci, Dept Hematol Endocrinol & Metab, 3-18-15 Kuramoto, Tokushima 7708503, Japan.
   [Teramachi, Jumpei] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Oral Funct & Anat, 2-5-1 Shikata cho, Kita ku, Okayama 7008530, Japan.
   [Endo, Itsuro] Tokushima Univ, Grad Sch Med Sci, Dept Bioregulatory Sci, 3-18-15 Kuramoto, Tokushima 7708503, Japan.
   [Matsumoto, Toshio] Tokushima Univ, Fujii Mem Inst Med Sci, 3-18-15 Kuramoto, Tokushima 7708503, Japan.
C3 Tokushima University; Tokushima University; Okayama University;
   Tokushima University; Tokushima University
RP Hiasa, M (corresponding author), Tokushima Univ, Grad Sch Biomed Sci, Dept Orthodont & Dentofacial Orthoped, 3-18-15 Kuramoto, Tokushima 7708503, Japan.; Abe, M (corresponding author), Tokushima Univ, Grad Sch Biomed Sci, Dept Hematol Endocrinol & Metab, 3-18-15 Kuramoto, Tokushima 7708503, Japan.
EM mhiasa@tokushima-u.ac.jp; masabe@tokushima-u.ac.jp
RI 日浅, 雅博/S-1537-2019; Tanaka, Eiji/E-7105-2015
OI HIASA, MASAHIRO/0000-0002-4830-6274; Tanaka, Eiji/0000-0002-2707-1613;
   Matsumoto, Toshio/0000-0002-0618-0941
FU JSPS KAKENHI [JP19K22719, JP17H05104, JP22K08455, JP22H03104]; Tokushima
   University [2202003, 1803003]; Grants-in-Aid for Scientific Research
   [23K21485, 23K15975, 23K16151, 23K19694, 22H03104, 22K08455, 22K19626,
   21K21016, 21H03111] Funding Source: KAKEN
FX This work was supported in part by the JSPS KAKENHI Grant Numbers
   JP19K22719, JP17H05104, JP22K08455, JP22H03104 and the Research Clusters
   program of Tokushima University (2202003, 1803003). The funders had no
   role in the study design, data collection and analysis, decision to
   publish, or preparation of the manuscript.
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NR 39
TC 9
Z9 9
U1 1
U2 10
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD JAN
PY 2023
VL 12
IS 1
AR 133
DI 10.3390/antiox12010133
PG 17
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA 8B5FB
UT WOS:000916947400001
PM 36670994
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Rajkovic, M
   Glavinic, U
   Ristanic, M
   Cosic, M
   Dimitrijevic-sreckovic, V
   Ilic, I
   Djelic, N
AF Rajkovic, Milan
   Glavinic, Uros
   Ristanic, Marko
   Cosic, Milivoje
   Dimitrijevic-sreckovic, Vesna
   Ilic, Iva
   Djelic, Ninoslav
TI DOES ORGANIC SPROUTED WHOLE WHEAT GRAIN FLOURLESS BREAD DECREASES DNA
   DAMAGE IN DIABETIC PATIENTS?
SO ACTA VETERINARIA-BEOGRAD
LA English
DT Article
DE diabetes; nutrition; flourless bread; DNA damage; Comet assay
ID MEDITERRANEAN DIET; METABOLIC SYNDROME; OXIDATIVE STRESS; COMET ASSAY;
   HUMAN-LYMPHOCYTES; IN-VITRO; OBESITY; MECHANISMS; RISK; CEREALS
AB Diabetes is one of the main health concerns, especially in developed countries. During the last few decades, the percentage of diabetic persons is constantly increasing. Although the genetic factors have a strong influence in the development of diabetes, environmental influence (physical inactivity, inadequate nutrition leading to obesity) also have an important impact. The main objective of this investigation was to evaluate the possible influence of organic sprouted whole wheat grain flourless bread Tonus (R) (product of Trivit, Becej, Serbia) on DNA damage at various stages of progression through type 2 diabetes mellitus (T2DM). In addition to control (non-diabetic) subjects we analyzed obese, pre-diabetic and diabetic patients, for a total of four experimental groups. All subjects used to eat Mediterranean diet for at least two years before being included in our study. In each of four groups we had five persons practicing the Mediterranean diet but instead of bread they consumed flourless bread Tonus (R). The DNA damage was evaluated on peripheral blood mononuclear cells by alkaline single cell gel electrophoresis (Comet) assay at the very beginning (before starting the Tonus (R) bread diet), and after exactly the three months of consumption of Tonus (R) bread. Statistical analysis revealed that only in patients with type 2 diabetes, Tonus (R) bread intake led to decreased DNA damage compared to the level of DNA damage of these patients before they started Tonus (R) bread diet. We assume that decrease of body weight and hyperinsulinemia caused by Tonus (R) bread in the diet might be one of the main causes of decreased DNA damage.
C1 [Rajkovic, Milan; Glavinic, Uros; Ristanic, Marko; Djelic, Ninoslav] Univ Belgrade, Dept Biol, Fac Vet Med, Bul Oslobodjenja 18, Belgrade, Serbia.
   [Cosic, Milivoje] Univ Bijeljina, Dept Anim Breeding, Fac Agr, Bijeljina, Bosnia & Herceg.
   [Dimitrijevic-sreckovic, Vesna] Univ Blegrade, Clin Ctr Serbia, Sch Med, Clin Endocrinol Diabet & Metab Dis, Doktora Subotica 13, Belgrade, Serbia.
   [Ilic, Iva] Inst Publ Hlth Serbia Dr Milan Jovanov Batut, Belgrade, Serbia.
C3 University of Belgrade; Clinical Centre of Serbia
RP Rajkovic, M (corresponding author), Univ Belgrade, Dept Biol, Fac Vet Med, Bul Oslobodjenja 18, Belgrade, Serbia.
EM mrajkovic@vet.bg.ac.rs
RI Glavinic, Uros/S-5451-2019
OI Rajkovic, Milan/0000-0002-5715-4786; , Milivoje
   Cosic/0000-0002-6999-2963; Glavinic, Uros/0000-0003-2143-1611; Ristanic,
   Marko/0000-0002-6084-7321
FU Ministry of Education, Science and Technological Development of the
   Republic of Serbia [III46002, 451-03-68/2020-14/200143, 248]
FX This study was supported by the Ministry of Education, Science and
   Technological Development of the Republic of Serbia through the Grant
   No. III46002 for a project led by Professor Zoran Stanimirovic, and
   Contract number 451-03-68/2020-14/200143 and Innovative voucher number
   248 (Innovation Fund of the Republic of Serbia, Principal Investigator
   Prof. Ninoslav Djelic).
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NR 38
TC 2
Z9 2
U1 2
U2 10
PU SCIENDO
PI WARSAW
PA BOGUMILA ZUGA 32A, WARSAW, MAZOVIA, POLAND
SN 0567-8315
EI 1820-7448
J9 ACTA VET-BEOGRAD
JI Acta Vet.-Beogr.
PD SEP
PY 2021
VL 71
IS 3
BP 273
EP 284
DI 10.2478/acve-2021-0024
PG 12
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA WB6DR
UT WOS:000703661100003
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Lokken, N
   Khawajazada, T
   Storgaard, JH
   Raaschou-Pedersen, D
   Christensen, ME
   Hornsyld, TM
   Krag, T
   Orngreen, MC
   Vissing, J
AF Lokken, Nicoline
   Khawajazada, Tahmina
   Storgaard, Jesper Helbo
   Raaschou-Pedersen, Daniel
   Christensen, Maja Elling
   Hornsyld, Tessa Munkeboe
   Krag, Thomas
   Orngreen, Mette C.
   Vissing, John
TI No effect of resveratrol in patients with mitochondrial myopathy: A
   cross-over randomized controlled trial
SO JOURNAL OF INHERITED METABOLIC DISEASE
LA English
DT Article
DE exercise capacity; mitochondrial metabolism; mitochondrial myopathy;
   RCT; resveratrol
ID ATTENUATES OXIDATIVE STRESS; CONTROLLED CLINICAL-TRIAL; SKELETAL-MUSCLE;
   HEALTHY-VOLUNTEERS; METABOLIC SYNDROME; ENERGY-METABOLISM;
   SUPPLEMENTATION; EXERCISE; FAT; MEN
AB Mitochondrial myopathies (MM) are caused by mutations that typically affect genes involved in oxidative phosphorylation. Main symptoms are exercise intolerance and fatigue. Currently, there is no specific treatment for MM. Resveratrol (RSV) is a nutritional supplement that in preclinical studies has been shown to stimulate mitochondrial function. We hypothesized that RSV could improve exercise capacity in patients with MM. The study design was randomized, double-blind, cross-over and placebo-controlled. Eleven patients with genetically verified MM were randomized to receive either 1000 mg/day RSV or placebo (P) for 8 weeks followed by a 4-week washout and then the opposite treatment. Primary outcomes were changes in heart rate (HR) during submaximal cycling exercise and peak oxygen utilization (VO(2)max) during maximal exercise. Secondary outcomes included reduction in perceived exertion, changes in lactate concentrations, self-rated function (SF-36) and fatigue scores (FSS), activities of electron transport chain complexes I and IV in mononuclear cells and mitochondrial biomarkers in muscle tissue among others. There were no significant differences in primary and secondary outcomes between treatments. Mean HR changes were -0.3 +/- 4.3 (RSV) vs 1.8 +/- 5.0 bpm (P), P = .241. Mean VO(2)max changes were 0.7 +/- 1.4 (RSV) vs -0.2 +/- 2.3 mL/min/kg (P), P = .203. The study provides evidence that 1000 mg RSV daily is ineffective in improving exercise capacity in adults with MM. These findings indicate that previous in vitro studies suggesting a therapeutic potential for RSV in MM, do not translate into clinically meaningful effects in vivo.
C1 [Lokken, Nicoline; Khawajazada, Tahmina; Storgaard, Jesper Helbo; Raaschou-Pedersen, Daniel; Hornsyld, Tessa Munkeboe; Krag, Thomas; Orngreen, Mette C.; Vissing, John] Univ Hosp, Rigshosp, Copenhagen Neuromuscular Ctr, Copenhagen, Denmark.
   [Christensen, Maja Elling] Univ Copenhagen, Dept Cellular & Mol Med, Ctr Hlth Aging, Copenhagen, Denmark.
C3 Rigshospitalet; University of Copenhagen; Copenhagen University
   Hospital; University of Copenhagen
RP Lokken, N (corresponding author), Rigshosp, Copenhagen Neuromuscular Ctr, Dept 8077,Blegdamsvej 9, DK-2100 Copenhagen, Denmark.
EM nicoline.loekken@regionh.dk
RI Krag, Thomas/AAD-3307-2021; Vissing, John/IUN-4271-2023; Løkken,
   Nicoline/GZL-0909-2022
OI Raaschou-Oddershede, Daniel Emil Tadeusz/0000-0002-0591-3656; Orngreen,
   Mette Cathrine/0000-0002-2991-6309; Storgaard, Jesper
   Helbo/0000-0003-0900-4908
FU Aase og Ejnar Danielsens Fond; Grosserer LF Foghts Fond; Jascha Fonden;
   Novo Nordisk Fonden
FX Aase og Ejnar Danielsens Fond; Grosserer LF Foghts Fond; Jascha Fonden;
   Novo Nordisk Fonden
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NR 50
TC 8
Z9 8
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0141-8955
EI 1573-2665
J9 J INHERIT METAB DIS
JI J. Inherit. Metab. Dis.
PD SEP
PY 2021
VL 44
IS 5
BP 1186
EP 1198
DI 10.1002/jimd.12393
EA MAY 2021
PG 13
WC Endocrinology & Metabolism; Genetics & Heredity; Medicine, Research &
   Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Genetics & Heredity; Research & Experimental
   Medicine
GA UN0EM
UT WOS:000649975900001
PM 33934389
DA 2025-06-11
ER

PT J
AU Ghanavati, M
   Hosseinabadi, SM
   Parsa, SA
   Safi, M
   Emamat, H
   Nasrollahzadeh, J
AF Ghanavati, Matin
   Hosseinabadi, Susan Mohammadi
   Parsa, Saeed Alipour
   Safi, Morteza
   Emamat, Hadi
   Nasrollahzadeh, Javad
TI Effect of a nut-enriched low-calorie diet on body weight and selected
   markers of inflammation in overweight and obese stable coronary artery
   disease patients: a randomized controlled study
SO EUROPEAN JOURNAL OF CLINICAL NUTRITION
LA English
DT Article
ID CARDIOVASCULAR RISK-FACTORS; MEDITERRANEAN DIET; METABOLIC SYNDROME;
   OXIDATIVE STRESS; PISTACHIO NUTS; CONSUMPTION; ALMONDS; HAZELNUTS
AB Background/objectives Weight loss through a low-calorie diet (LCD) could improve low-grade inflammation evident in the obese state. Few studies have evaluated the effect of the mixed nuts consumption in the context of a LCD on inflammatory biomarkers. This study compared the effects of a nut-enriched LCD (NELCD) with a nut-free LCD (NFLCD) on body weight and inflammatory markers in overweight or obese coronary artery disease (CAD) patients.
   Subjects/method In this randomized controlled parallel trial, patients with stable CAD of both genders were randomly allocated to 8-week NELCD or NFLCD. Body weight, plasma C-reactive protein (CRP), interleukin-6 (IL-6), interleukin 10 (IL-10), intercellular adhesion molecule-1 (ICAM-1), and monocyte chemoattractant protein (MCP-1) were assessed at baseline and 8 weeks.
   Results Overall, 67 patients (aged 58.8 +/- 7.4 years; BMI 30.9 +/- 3.9 kg/m(2)) completed the study. Participants in both groups lost weight to a comparable extent. Patients in the NELCD group showed a decrease in ICAM-1 (p = 0.04) and IL-6 (p = 0.02) concentrations compared to NFLCD group. No significant difference in concentrations of MCP-1, IL-10, or CRP was observed between diet groups.
   Conclusions Nuts are healthy energy-dense foods that if included in controlled amounts in a weight management program can still result in weight reduction and may improve some plasma concentration of inflammatory factors, such as ICAM-1 and IL-6.
C1 [Ghanavati, Matin; Hosseinabadi, Susan Mohammadi; Emamat, Hadi; Nasrollahzadeh, Javad] Shahid Beheshti Univ Med Sci, Res Inst, Natl Nutr & Food Technol, Dept Clin Nutr & Dietet,Fac Nutr Sci & Food Techn, Tehran, Iran.
   [Parsa, Saeed Alipour; Safi, Morteza] Shahid Beheshti Univ Med Sci, Cardiovasc Res Ctr, Tehran, Iran.
C3 Shahid Beheshti University Medical Sciences; Shahid Beheshti University
   Medical Sciences
RP Nasrollahzadeh, J (corresponding author), Shahid Beheshti Univ Med Sci, Res Inst, Natl Nutr & Food Technol, Dept Clin Nutr & Dietet,Fac Nutr Sci & Food Techn, Tehran, Iran.
EM jnasrollahzadeh@gmail.com
RI safi, morteza/P-2932-2018; Nasrollahzadeh, Javad/AIE-5000-2022; Parsa,
   Saeed/J-1428-2016; Emamat, Hadi/AAJ-7525-2020; Ghanavati,
   Matin/AAD-6617-2022
OI Nasrollahzadeh, Javad/0000-0002-9133-1870; Emamat,
   Hadi/0000-0002-8562-9136; Ghanavati, Matin/0000-0001-7447-3845
FU National Nutrition and Food Technology Research Institute, Shahid
   Beheshti University of Medical Science, Tehran, Iran
FX This research is funded by the National Nutrition and Food Technology
   Research Institute, Shahid Beheshti University of Medical Science,
   Tehran, Iran.
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NR 52
TC 20
Z9 20
U1 1
U2 17
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0954-3007
EI 1476-5640
J9 EUR J CLIN NUTR
JI Eur. J. Clin. Nutr.
PD JUL
PY 2021
VL 75
IS 7
BP 1099
EP 1108
DI 10.1038/s41430-020-00819-9
EA JAN 2021
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA TG4AQ
UT WOS:000606311700001
PM 33420472
DA 2025-06-11
ER

PT J
AU Basri, NRH
   Mohktar, MS
   Zaman, WSWK
   Rengasamy, S
AF Basri, Nur Rasyidah Hasan
   Mohktar, Mas Sahidayana
   Zaman, Wan Safwani Wan Kamarul
   Rengasamy, Selvam
TI Predicting Blood Glucose Level in Malaysian Women Based on Glutathione
   and Anthropometric Parameters
SO ACTA SCIENTIARUM-TECHNOLOGY
LA English
DT Article
DE Glutathione; blood glucose; prediction
ID METABOLIC SYNDROME; REGRESSION; DISEASE; MODELS
AB Blood glucose is conventionally determined by the level of sugar present in our blood. Lesser known to the public that antioxidants in our body are also said to influence the level of blood glucose. Glutathione (GSH) as the main antioxidant parameter in our body helps in reducing the production of oxidative stress caused by a high blood glucose level. Particularly in women, high antioxidant activities are reported due to the presence of oestrogen hormone. However, in Malaysia limited study was done on the significance of GSH in influencing the blood glucose level. Thus, this study focuses on finding the significance of GSH and some other health predictors in affecting the blood glucose level of women volunteers. This study was carried out on 118 Malaysian women volunteers and blood samples were collected for GSH analysis and blood glucose. All data were trained and tested for the development of prediction models in classifying the blood glucose into normal and abnormal levels. The model construction is using three different classifiers: namely logistic regression, k-nearest neighbour classifier and decision tree. Five predictors that were used are GSH, weight, body mass index (BMI), waist-hip ratio (WHR) and groups (oral supplementation dosage). Results showed all predictors are significantly correlated with the blood glucose level at p < 0.10. The model with a combination of GSH, BMI, WHR, weight and supplementation dosage (groups) as predictors gave the best performance. The k-nearest neighbour classifier model displays the best accuracy (84.7%) in predicting the normal and abnormal level of blood glucose. This finding shows that by altering the amount of GSH via oral supplementation and other significant predictors in women, there are chances to modify the blood glucose level from abnormal to normal.
C1 [Basri, Nur Rasyidah Hasan; Mohktar, Mas Sahidayana; Zaman, Wan Safwani Wan Kamarul] Univ Malaya, Fac Engn, Dept Biomed Engn, Kuala Lumpur 50603, Malaysia.
   [Basri, Nur Rasyidah Hasan; Mohktar, Mas Sahidayana; Zaman, Wan Safwani Wan Kamarul] Univ Malaya, Fac Engn, Ctr Innovat Med Engn, Kuala Lumpur, Malaysia.
   [Rengasamy, Selvam] Chakra We Care Resources Sdn Bhd, A-G-15, Petaling Jaya, Selangor, Malaysia.
C3 Universiti Malaya; Universiti Malaya
RP Mohktar, MS (corresponding author), Univ Malaya, Fac Engn, Dept Biomed Engn, Kuala Lumpur 50603, Malaysia.; Mohktar, MS (corresponding author), Univ Malaya, Fac Engn, Ctr Innovat Med Engn, Kuala Lumpur, Malaysia.
EM mas_dayana@um.edu.my
RI MOKHTAR, MAS SAHIDAYANA/B-5313-2010; Zaman, Wan/L-1321-2015
FU Chakra We Care Resources Sdn. Bhd. [PV004-2017, RK011-2018]
FX This research was supported and funded by Chakra We Care Resources Sdn.
   Bhd. (Project No. RK011-2018, PV004-2017).
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NR 22
TC 0
Z9 0
U1 0
U2 3
PU UNIV ESTADUAL MARINGA, PRO-REITORIA PESQUISA POS-GRADUACAO
PI MARINGA
PA AV. COLOMBO, 5790, DIVISAO DE DIVULGACAO CIENTIFICA, MARINGA, PR
   87020-900, BRAZIL
SN 1806-2563
EI 1807-8664
J9 ACTA SCI-TECHNOL
JI Acta Sci.-Technol.
PD JAN-DEC
PY 2021
VL 43
AR e56373
DI 10.4025/actascitechnol.v43i1.56373
PG 8
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA XI1HA
UT WOS:000725870700034
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Mohamed, HE
   Asker, ME
   Keshawy, MM
   Hasan, RA
   Mahmoud, YK
AF Mohamed, Hoda E.
   Asker, Mervat E.
   Keshawy, Mohammed M.
   Hasan, Rehab A.
   Mahmoud, Yasmin K.
TI Inhibition of tumor necrosis factor-α enhanced the antifibrotic effect
   of empagliflozin in an animal model with renal insulin resistance
SO MOLECULAR AND CELLULAR BIOCHEMISTRY
LA English
DT Article
DE Empagliflozin; Infliximab; Insulin resistance; Renal fibrosis; Sirt 1
ID NF-KAPPA-B; TO-MESENCHYMAL TRANSITION; OXIDATIVE STRESS; METABOLIC
   SYNDROME; KIDNEY-DISEASE; TNF-ALPHA; ANKYLOSING-SPONDYLITIS;
   GLUCOSE-HOMEOSTASIS; CURCUMIN IMPROVES; ADIPOSE-TISSUE
AB Insulin resistance (IR) has emerged as one of the main risk factors for renal fibrosis (RF) that represents a common stage in almost all chronic kidney disease. The present study aims to investigate the inhibitory effect of empagliflozin (EMPA "a sodium-glucose co-transporter 2 inhibitor") and infliximab [IFX "a tumor necrosis factor-alpha (TNF-alpha) antibody"] on RF in rats with induced IR. IR was induced by adding 10% fructose in drinking water for 20 weeks. Thereafter, fructose-induced IR rats were concurrently treated with EMPA (30 mg/kg), IFX (1 dose 5 mg/kg), or EMPA + IFX for 4 weeks, in addition to IR control group (received 10% fructose in water) and normal control (NC) group. Rats with IR displayed hyperglycemia, deterioration in kidney functions, glomerulosclerosis, and collagen fiber deposition in renal tissues as compared to NC. This was associated with downregulation of the renal sirtuin 1 (Sirt 1) expression along with higher renal tissue TNF-alpha and transforming growth factor-beta 1 (TGF-beta 1) levels. Both EMPA and IFX significantly modulated the aforementioned fibrotic cytokines, upregulated the renal Sirt 1 expression, and attenuated RF compared to IR control group. Of note, IFX effect was superior to that of EMPA. However, the combination of EMPA and IFX alleviated RF to a greater extent surpassing the monotherapy. This may be attributed to the further upregulation of renal Sirt 1 in addition to the downregulation of fibrotic cytokines. These findings suggest that the combination of EMPA and IFX offers additional benefits and may represent a promising therapeutic option for RF.
C1 [Mohamed, Hoda E.; Asker, Mervat E.; Mahmoud, Yasmin K.] Zagazig Univ, Fac Pharm, Dept Biochem, Zagazig, Egypt.
   [Keshawy, Mohammed M.] Suez Canal Univ, Fac Med, Dept Internal Med, Nephrol Div, Ismailia, Ismailia, Egypt.
   [Hasan, Rehab A.] Al Azhar Univ, Fac Med Girls, Dept Histol, Cairo, Egypt.
C3 Egyptian Knowledge Bank (EKB); Zagazig University; Egyptian Knowledge
   Bank (EKB); Suez Canal University; Egyptian Knowledge Bank (EKB); Al
   Azhar University
RP Mohamed, HE (corresponding author), Zagazig Univ, Fac Pharm, Dept Biochem, Zagazig, Egypt.
EM hodael_sayed@yahoo.com
OI Keshawy, Mohammed/0000-0001-8080-513X
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NR 85
TC 27
Z9 27
U1 0
U2 2
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0300-8177
EI 1573-4919
J9 MOL CELL BIOCHEM
JI Mol. Cell. Biochem.
PD MAR
PY 2020
VL 466
IS 1-2
BP 45
EP 54
DI 10.1007/s11010-020-03686-x
PG 10
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA KN4IH
UT WOS:000514801900005
PM 31933108
DA 2025-06-11
ER

PT J
AU Bonifacino, E
   Schwartz, EB
   Jun, H
   Wessel, CB
   Corbelli, JA
AF Bonifacino, Eliana
   Schwartz, Eleanor B.
   Jun, Hyejo
   Wessel, Charles B.
   Corbelli, Jennifer A.
TI Effect of Lactation on Maternal Hypertension: A Systematic Review
SO BREASTFEEDING MEDICINE
LA English
DT Review
DE hypertension; maternal health; lactation
ID BLOOD-PRESSURE; METABOLIC SYNDROME; DURATION; RISK; MOTHERS; ADIPOSITY;
   DISEASE; STRESS; WOMEN
AB Introduction: Hypertension is relatively common in pregnancy, and pregnancy may unmask hypertension among women who are predisposed to it. Lactation may be a means through which to mitigate pregnancy-related vascular risk. The impact of lactation on maternal blood pressure, and the duration of any effect, remains unclear. This study aimed at systematically reviewing the literature evaluating the impact of lactation on the development of hypertension. Materials and Methods: We searched PubMed, including EMBASE and MEDLINE, for studies that reported on the association between breastfeeding and maternal risk of hypertension that were published in a peer-reviewed source. The quality of the studies included was assessed by using the Newcastle-Ottawa Scale. Results: Nineteen studies met all inclusion criteria for this review. Of the four studies with short-term follow-up, 50% showed a protective association. The fifteen studies with longer-term follow-up were stratified by outcome assessed. Sixty-seven percent of the studies that evaluated for elevated blood pressure and 100% of the studies evaluating for an outcome of hypertension showed a protective association. The minimum duration of lactation associated with a benefit was 1 month. This association was demonstrated in follow-up periods as long as two to three decades. Studies that showed a protective association had overall higher quality ratings. Discussion: Lactation is associated with a beneficial effect on maternal blood pressure that persists for decades. These results add to the growing body of literature demonstrating the protective association of lactation on maternal cardiovascular risk. Providers may incorporate the decreased risk of hypertension into their counseling on the maternal benefits of lactation.
C1 [Bonifacino, Eliana; Corbelli, Jennifer A.] Dept Med, Div Gen Internal Med, Pittsburgh, PA USA.
   [Schwartz, Eleanor B.] Univ Calif Davis, Med Ctr, Dept Med, Div Gen Internal Med, Sacramento, CA 95817 USA.
   [Jun, Hyejo] Hlth Ctr Women, St Paul, MN USA.
   [Wessel, Charles B.] Univ Pittsburgh, Hlth Sci Lib Syst, Pittsburgh, PA USA.
C3 University of California System; University of California Davis;
   Pennsylvania Commonwealth System of Higher Education (PCSHE); University
   of Pittsburgh
RP Bonifacino, E (corresponding author), Montefiore Hosp, Dept Med, Div Gen Internal Med, 9S,200 Lothrop St, Pittsburgh, PA 15213 USA.
EM bonifacinoe@upmc.edu
RI Wessel, Charles B./B-2318-2013
OI Wessel, Charles B./0000-0002-5018-0156
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NR 55
TC 31
Z9 34
U1 0
U2 3
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1556-8253
EI 1556-8342
J9 BREASTFEED MED
JI Breastfeed. Med.
PD NOV
PY 2018
VL 13
IS 9
BP 578
EP 588
DI 10.1089/bfm.2018.0108
EA OCT 2018
PG 11
WC Obstetrics & Gynecology; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology; Pediatrics
GA HB0EU
UT WOS:000446668400001
PM 30299974
DA 2025-06-11
ER

PT J
AU Cozzani, E
   Rosa, GM
   Burlando, M
   Parodi, A
AF Cozzani, Emanuele
   Rosa, Gian Marco
   Burlando, Martina
   Parodi, Aurora
TI Psoriasis as a cardiovascular risk factor: updates and algorithmic
   approach
SO GIORNALE ITALIANO DI DERMATOLOGIA E VENEREOLOGIA
LA English
DT Review
DE Psoriasis; Risk factors; Cardiovascular diseases
ID MYOCARDIAL-INFARCTION; METABOLIC SYNDROME; ENDOTHELIAL DYSFUNCTION;
   ANTIINFLAMMATORY DRUGS; RHEUMATOID-ARTHRITIS; NATRIURETIC PEPTIDE; GENE
   POLYMORPHISMS; VASCULAR-DISEASES; SERUM YKL-40; KAPPA-B
AB Although psoriasis is predominantly a chronic inflammatory skin disorder, it has been known to be associated with cardiovascular disease. Patients with psoriasis, particularly with moderate to severe forms, present an increased rate of cardiovascular mortality, myocardial infarction and stroke. However the pathophysiology of the relationship between psoriasis and cardiovascular risk and comorbidities has not yet completely known. Chronic inflammation may be considered a solid link between psoriasis and related cardiovascular events. Several cytokines and inflammatory cells play a pivotal role in the development of psoriatic lesions, resulting in angiogenesis and endothelial dysfunction. Furthermore, the imbalance between oxidative stress and antioxidant mechanisms in psoriatic patients may contribute to explain the pathogenesis of increased reactive oxygen species and the formation of atherosclerotic plaque. Other mechanistic pathways which may be involved in this relationship include cardiovascular effects of medications, a common genetic background and a higher prevalence of cardiovascular risk factors, which are often under-diagnosed and under-treated in psoriatic patients. Indeed, the early detection of specific markers of cardiovascular impairment, such as N-terminal pro B-type natriuretic peptide, homocysteine and YKL-40, may enable psoriatic patients at higher cardiovascular risk to be identified as soon as possible. This review examines the increased cardiovascular risk profile and high prevalence of cardiovascular disease associated with psoriasis, focusing on pathogenic links between psoriasis and atherosclerosis, serological markers of cardiovascular involvement and the implications of antipsoriatic therapies on cardiovascular risk and proposes a flow chart, that every dermatologist should follow to screen psoriatic patients.
C1 [Cozzani, Emanuele; Burlando, Martina; Parodi, Aurora] Univ Genoa, Dept Dermatol, San Martino Policlin, Genoa, Italy.
   [Rosa, Gian Marco] Univ Genoa, Dept Cardiol, San Martino Policlin, Genoa, Italy.
C3 University of Genoa; University of Genoa
RP Cozzani, E (corresponding author), Univ Genoa, Dept Dermatol, San Martino Policlin, Genoa, Italy.
EM emanuele.cozzani@unige.it
RI Cozzani, Emanuele/AAC-2597-2019; Burlando, Martina/AAC-2594-2019
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NR 76
TC 5
Z9 5
U1 0
U2 4
PU EDIZIONI MINERVA MEDICA
PI TURIN
PA CORSO BRAMANTE 83-85 INT JOURNALS DEPT., 10126 TURIN, ITALY
SN 0392-0488
EI 1827-1820
J9 GIORN ITAL DERMAT V
JI G. Ital. Dermatol. Venereol.
PD OCT
PY 2018
VL 153
IS 5
BP 659
EP 665
DI 10.23736/S0392-0488.18.06040-6
PG 7
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA HH9KU
UT WOS:000456057900010
PM 29683293
DA 2025-06-11
ER

PT J
AU Horman, T
   Fernandes, MF
   Zhou, Y
   Fuller, B
   Tigert, M
   Leri, F
AF Horman, Thomas
   Fernandes, Maria Fernanda
   Zhou, Yan
   Fuller, Benjamin
   Tigert, Melissa
   Leri, Francesco
TI An exploration of the aversive properties of 2-deoxy-D-glucose in rats
SO PSYCHOPHARMACOLOGY
LA English
DT Article
DE Place avoidance; 2-Deoxy-D-glucose; Corticosterone; Blood glucose;
   Clonidine; Bupropion
ID CONDITIONED PLACE PREFERENCE; ACUTE HYPOGLYCEMIA; METABOLIC SYNDROME;
   DOPAMINE NEURONS; FEEDING RESPONSE; NERVOUS-SYSTEM; LOCUS-CERULEUS;
   CHRONIC STRESS; FOOD-INTAKE; BUPROPION
AB Hypoglycemia can alter arousal and negatively impact mood. This study tests the hypothesis that acute drops in glucose metabolism cause an aversive state mediated by monoamine activity. In experiment 1, male Sprague-Dawley rats were either food deprived (FD) or pre-fed (PF) and tested on conditioned place avoidance (CPA; biased place conditioning design; 3 pairings drug/vehicle, each 30 min-long) induced by the glucose antimetabolite 2-deoxy-d-glucose (2-DG; 0, 300 or 500 mg/kg, SC). Locomotion and blood glucose were also assessed. Experiment 2 examined whether clonidine (noradrenergic alpha 2 agonist, 0, 10 or 40 mu g/kg, SC) or bupropion (monoamine reuptake blocker, 0, 10 or 30 mg/kg, SC) could alter CPA induced by 500 mg/kg 2-DG. In experiment 3, blood corticosterone (CORT) was measured in response to 500 mg/kg 2-DG, alone or in combination with 40 mu g/kg clonidine or 30 mg/kg bupropion. Finally, experiment 4 controlled for possible place conditioning induced by 10 or 40 mu g/kg clonidine, or 10 or 30 mg/kg bupropion injected without 2-DG. It was found that 2-DG increased blood glucose and produced a robust CPA. The feeding status of the animals modulated these effects, including CORT levels. Both clonidine and bupropion attenuated the effects of 2-DG on CPA and CORT, but only bupropion reversed suppression of locomotion. Taken together, these results in rats suggest that impaired glucose metabolism can negatively impact arousal and mood via effects on HPA and monoamine systems.
C1 [Horman, Thomas; Fernandes, Maria Fernanda; Fuller, Benjamin; Tigert, Melissa; Leri, Francesco] Univ Guelph, Dept Psychol & Neurosci, Guelph, ON N1G 2W1, Canada.
   [Zhou, Yan] Rockefeller Univ, Lab Biol Addict Dis, 1230 York Ave, New York, NY 10021 USA.
C3 University of Guelph; Rockefeller University
RP Leri, F (corresponding author), Univ Guelph, Dept Psychol & Neurosci, Guelph, ON N1G 2W1, Canada.
EM fleri@uoguelph.ca
OI Fernandes, Maria Fernanda/0000-0001-5649-3068; Leri,
   Francesco/0000-0003-2700-0812
FU Ontario Brain Institute; Ontario government
FX This study was part of the Canadian Biomarker Integration Network in
   Depression (CAN-BIND) program (www.canbind.ca). CAN-BIND is an
   Integrated Discovery Program carried out in partnership with, and
   financial support from, the Ontario Brain Institute, an independent
   non-profit corporation, funded partially by the Ontario government. The
   opinions, results, and conclusions are those of the authors, and no
   endorsement by the Ontario Brain Institute is intended or should be
   inferred.
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NR 50
TC 9
Z9 11
U1 0
U2 2
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0033-3158
EI 1432-2072
J9 PSYCHOPHARMACOLOGY
JI Psychopharmacology
PD OCT
PY 2018
VL 235
IS 10
BP 3055
EP 3063
DI 10.1007/s00213-018-4998-1
PG 9
WC Neurosciences; Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA GV5KM
UT WOS:000446140500022
PM 30112578
DA 2025-06-11
ER

PT J
AU Tresserra-Rimbau, A
   Lamuela-Raventos, RM
   Moreno, JJ
AF Tresserra-Rimbau, Anna
   Lamuela-Raventos, Rosa M.
   Moreno, Juan J.
TI Polyphenols, food and pharma. Current knowledge and directions for
   future research
SO BIOCHEMICAL PHARMACOLOGY
LA English
DT Article
DE Bioactive compounds; Flavonoids; Antioxidants; Bioavailability;
   Processing/cooking; Pharmacology
ID MAJOR FOOD; PHENOLIC-COMPOUNDS; OXIDATIVE STRESS; NATURAL-PRODUCTS;
   DIETARY-INTAKE; IN-VITRO; BIOLOGICAL-ACTIVITIES; CARDIOVASCULAR RISK;
   METABOLIC SYNDROME; RESVERATROL
AB Polyphenols are a large family of phytochemicals with great chemical diversity, known to be bioactive compounds of foods, species, medicinal plants and nutraceuticals. These compounds are ingested through the diet in significant amounts, around 1 g per day, an amount that be may be increased through supplements. The in vitro action of many representative polyphenols has been reported. However, their beneficial effects and their role in modulating the risk of high-prevalence diseases are difficult to demonstrate due to the wide variability of polyphenol structures and bioactive actions; the complexity of estimating the polyphenol content of food as a result of their variability in foods and cooked dishes; the potential modulation of the effects of polyphenols by food matrices; the addition of polyphenols and their synergistic interactions with each other and with other dietary bioactive components; the modulation of polyphenol bioavailability as a consequence of food composition and culinary techniques; their metabolism by the human body and the polyphenol gut microbiota metabolism in each metabotypes. Computational strategies, including virtual screening, shape-similarity-screening and molecular docking, were recently used to identify potential targets of polyphenols and thus gain a better understanding of the therapeutic effects exerted of polyphenols and modify natural polyphenol structures to potentiate specific activities. Here, we present the most relevant current knowledge and propose directions for future research in these fields, from the culinary world to the clinical setting. We hope this commentary will prompt scientists and clinicians to consider the therapeutic value of bioactive polyphenols and help shed some light on how much scientific truth lies in Hippocrates' famous quote: "Let your food be your medicine".
C1 [Tresserra-Rimbau, Anna] Univ Rovira & Virgili, Pere Virgili Hlth Res Ctr, Univ Hosp St Joan de Reus, Human Nutr Unit,Dept Biochem & Biotechnol,Fac Med, Reus, Spain.
   [Tresserra-Rimbau, Anna; Lamuela-Raventos, Rosa M.; Moreno, Juan J.] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr CIBEROBN, Madrid, Spain.
   [Lamuela-Raventos, Rosa M.; Moreno, Juan J.] Univ Barcelona, Dept Nutr Food Sci & Gastron, Campus Torribera,Avda Prat de la Riba 171, Barcelona 08921, Spain.
   [Lamuela-Raventos, Rosa M.; Moreno, Juan J.] Univ Barcelona, Inst Nutr & Food Safety, Barcelona, Spain.
C3 Universitat Rovira i Virgili; Instituto de Salud Carlos III; CIBER -
   Centro de Investigacion Biomedica en Red; CIBEROBN; University of
   Barcelona; University of Barcelona
RP Moreno, JJ (corresponding author), Univ Barcelona, Dept Nutr Food Sci & Gastron, Campus Torribera,Avda Prat de la Riba 171, Barcelona 08921, Spain.
EM jjmoreno@ub.edu
RI Moreno, Juan/AAA-1312-2019; Raventos, Rosa/F-3986-2016;
   Tresserra-Rimbau, Anna/ABD-1099-2020
OI Tresserra-Rimbau, Anna/0000-0002-7022-9041
FU Spanish Ministry of Education and Science [BFU2004-04960,
   BFU2007-61727]; Spanish Ministry of Economy, Industry and
   Competitiveness [AGL2013-49083-C3-1R, AGL2016-75329R]; Spanish Ministry
   of Health [PI052629, RD06/0045/0012, CIBEROBN]
FX The original studies carried out in our laboratories and described in
   this commentary were supported by the Spanish Ministry of Education and
   Science (BFU2004-04960, BFU2007-61727), by the Spanish Ministry of
   Economy, Industry and Competitiveness (AGL2013-49083-C3-1R,
   AGL2016-75329R) and the Spanish Ministry of Health (PI052629,
   RD06/0045/0012 and CIBEROBN).
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NR 115
TC 186
Z9 188
U1 14
U2 128
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0006-2952
EI 1873-2968
J9 BIOCHEM PHARMACOL
JI Biochem. Pharmacol.
PD OCT
PY 2018
VL 156
BP 186
EP 195
DI 10.1016/j.bcp.2018.07.050
PG 10
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA GY3XX
UT WOS:000448491500019
PM 30086286
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Chen, YP
   Kuo, WW
   Baskaran, R
   Day, CH
   Chen, RJ
   Wen, SY
   Ho, TJ
   Padma, VV
   Kuo, CH
   Huang, CY
AF Chen, Yeh-Peng
   Kuo, Wei-Wen
   Baskaran, Rathinasamy
   Day, Cecilia-Hsuan
   Chen, Ray-Jade
   Wen, Su-Ying
   Ho, Tsung-Jung
   Padma, Viswanadha Vijaya
   Kuo, Chia-Hua
   Huang, Chih-Yang
TI Acute hypoxic preconditioning prevents palmitic acid-induced
   cardiomyocyte apoptosis via switching metabolic GLUT4-glucose pathway
   back to CD36-fatty acid dependent
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Article
DE fatty acid metabolism; glucose metabolism; hypoxia; insulin signaling
   pathway; ischemia; palmitic acid
ID ACTIVATED PROTEIN-KINASE; INTERMITTENT-HYPOXIA; HYPOBARIC HYPOXIA;
   SHORT-TERM; RESVERATROL; GLUCOSE; STRESS; HEARTS; PHOSPHORYLATION;
   TRANSLOCATION
AB Metabolic syndrome is a risk factor for the development of cardiovascular diseases. Myocardial cell damage leads to an imbalance of energy metabolism, and many studies have indicated that short-term hypoxia during myocardial cell injury has a protective effect. In our previous animal studies, we found that short-term hypoxia in the heart has a protective effect, but long-term hypoxia increases myocardial cell injury. Palmitic acid (PA)-treated H9c2 cardiomyoblasts and neonatal rat ventricle cardiomyocytes were used to simulate hyperlipidemia model, which suppress cluster of differentiation 36 (CD36) and activate glucose transporter type 4 (GLUT4). We exposed the cells to short- and long-term hypoxia and investigated the protective effects of hypoxic preconditioning on PA-induced lipotoxicity in H9c2 cardiomyoblasts and neonatal rat cardiomyocytes. Preconditioning with short-term hypoxia enhanced both CD36 and GLUT4 metabolism pathway protein levels. Expression levels of phospho-PI3K, phospho-Akt, phospho-AMPK, SIRT1, PGC1, PPAR, CD36, and CPT1 induced by PA was reversed by short-term hypoxia in a time-dependent manner. PA-induced increased GLUT4 membrane protein level was reduced in the cells exposed to short-term hypoxia and si-PKC. Short-term hypoxia, resveratrol and si-PKC rescue H9c2 cells from apoptosis induced by PA and switch the metabolic pathway from GLUT4 dependent to CD36 dependent. We demonstrate short-term hypoxic preconditioning as a more efficient way as resveratrol in maintaining the energy metabolism of hearts during hyperlipidemia and can be used as a therapeutic strategy.
C1 [Chen, Yeh-Peng] China Med Univ, PhD Program Aging, Taichung, Taiwan.
   [Chen, Yeh-Peng] China Med Univ, Div Cardiol, Dept Internal Med, China Med Univ Hosp, Taichung, Taiwan.
   [Kuo, Wei-Wen] China Med Univ, Dept Biol Sci & Technol, Taichung, Taiwan.
   [Baskaran, Rathinasamy] Natl Hlth Res Inst, Natl Inst Canc Res, Zhunan, Miaoli County, Taiwan.
   [Day, Cecilia-Hsuan] Mei Ho Univ, Dept Nursing, Pingtung, Taiwan.
   [Chen, Ray-Jade] Taipei Med Univ, Dept Surg, Sch Med, Taipei, Taiwan.
   [Wen, Su-Ying] Taipei City Hosp, Dept Dermatol, Renai Branch, Taipei, Taiwan.
   [Ho, Tsung-Jung] China Med Univ, Dept Chinese Med, Beigang Hosp, Taichung, Taiwan.
   [Ho, Tsung-Jung; Huang, Chih-Yang] China Med Univ, Grad Inst Chinese Med Sci, 91 Hsueh Shih Rd, Taichung 404, Taiwan.
   [Padma, Viswanadha Vijaya] Bharathiar Univ, Dept Biotechnol, Coimbatore, Tamil Nadu, India.
   [Kuo, Chia-Hua] Univ Taipei, Dept Sports Sci, Taipei, Taiwan.
   [Huang, Chih-Yang] China Med Univ, Grad Inst Basic Med Sci, Taichung, Taiwan.
   [Huang, Chih-Yang] Asia Univ, Dept Hlth & Nutr Biotechnol, Taichung, Taiwan.
C3 China Medical University Taiwan; China Medical University Taiwan; China
   Medical University Hospital - Taiwan; China Medical University Taiwan;
   National Health Research Institutes - Taiwan; Taipei Medical University;
   Taipei City Hospital; China Medical University Taiwan; China Medical
   University Taiwan; Bharathiar University; University of Taipei; China
   Medical University Taiwan; Asia University Taiwan
RP Huang, CY (corresponding author), China Med Univ, Grad Inst Chinese Med Sci, 91 Hsueh Shih Rd, Taichung 404, Taiwan.
EM cyhuang@mail.cmu.edu.tw
RI Baskaran, Rathinasamy/I-3345-2019; Chen, Ray/GRJ-6736-2022; Kuo,
   Chin-Sung/JCE-4770-2023; Huang, Kevin Chih-Yang/Q-4862-2016
OI Kuo, Chia-Hua/0000-0002-1731-4984; Baskaran,
   Rathinasamy/0000-0002-2676-7379; Huang, Chih-Yang/0000-0003-2347-0411
FU China Medical University; Taiwan Ministry of Health and Welfare Clinical
   Trial and Research Center of Excellence [DMR-104-007,
   MOHW106-TDU-B-212-113004]
FX China Medical University and Taiwan Ministry of Health and Welfare
   Clinical Trial and Research Center of Excellence, Grant numbers:
   DMR-104-007, MOHW106-TDU-B-212-113004
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NR 39
TC 20
Z9 21
U1 1
U2 24
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0730-2312
EI 1097-4644
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PD APR
PY 2018
VL 119
IS 4
BP 3363
EP 3372
DI 10.1002/jcb.26501
PG 10
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA FX6IO
UT WOS:000426187500034
PM 29130531
DA 2025-06-11
ER

PT J
AU Srinivasan, K
AF Srinivasan, Krishnapura
TI Cumin (Cuminum cyminum) and black cumin (Nigella sativa)
   seeds: traditional uses, chemical constituents, and nutraceutical
   effects
SO FOOD QUALITY AND SAFETY
LA English
DT Review
DE Cuminum cyminum; Nigella sativa; digestive stimulant; antidiabetic;
   anti-inflammatory; cancer preventive; immune stimulatory;
   gastroprotective
ID ISCHEMIA-REPERFUSION INJURY; LIPID-PEROXIDATION; ESSENTIAL OIL; CANCER
   CELLS; DIGESTIVE ENZYMES; ACTIVE PRINCIPLES; OXIDATIVE STRESS; DIETARY
   SPICES; VOLATILE OIL; L. SEEDS
AB Although the seeds of cumin (Cuminum cyminum L.) are widely used as a spice for their distinctive aroma, they are also commonly used in traditional medicine to treat a variety of diseases. The literature presents ample evidence for the biomedical activities of cumin, which have generally been ascribed to its bioactive constituents such as terpenes, phenols, and flavonoids. Those health effects of cumin seeds that are experimentally validated are discussed in this review. Black seeds (Nigella sativa), which are totally unrelated to C. cyminum, have nevertheless taken the name 'Black cumin' and used in traditional systems of medicine for many disorders. Numerous preclinical and clinical trials have investigated its efficacy using the seed oil, essential oil, and its main constituent thymoquinone (TQ). These investigations support its use either independently or as an adjunct along with conventional drugs in respiratory problems, allergic rhinitis, dyspepsia, metabolic syndrome, diabetes mellitus, inflammatory diseases, and different types of human cancer. Multiple studies made in the last decades validate its health beneficial effects particularly in diabetes, dyslipidemia, hypertension, respiratory disorders, inflammatory diseases, and cancer. Nigella sativa seeds also possess immune stimulatory, gastroprotective, hepatoprotective, nephroprotective, and neuroprotective activities. TQ is the most abundant constituent of volatile oil of N. sativa seeds, and most of the medicinal properties of N. sativa are attributed mainly to TQ. All the available evidence suggests that TQ should be developed as a novel drug in clinical trials.
C1 [Srinivasan, Krishnapura] Cent Food Technol Res Inst, CSIR, Dept Biochem, Mysore 570020, Karnataka, India.
C3 Council of Scientific & Industrial Research (CSIR) - India; CSIR -
   Central Food Technological Research Institute (CFTRI)
RP Srinivasan, K (corresponding author), Cent Food Technol Res Inst, CSIR, Dept Biochem, Mysore 570020, Karnataka, India.
EM ksri.cftri@gmail.com
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NR 121
TC 138
Z9 146
U1 4
U2 36
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 2399-1399
EI 2399-1402
J9 FOOD QUAL SAF-OXFORD
JI Food Qual. Saf.
PD MAR
PY 2018
VL 2
IS 1
BP 1
EP 16
DI 10.1093/fqsafe/fyx031
PG 16
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA GL5GX
UT WOS:000437193500001
OA gold
DA 2025-06-11
ER

PT J
AU Jarzab, A
   Kukula-Koch, W
AF Jarzab, Agata
   Kukula-Koch, Wirginia
TI Recent Advances in Obesity: The Role of Turmeric Tuber and Its
   Metabolites in the Prophylaxis and Therapeutical Strategies
SO CURRENT MEDICINAL CHEMISTRY
LA English
DT Review
DE Obesity; Curcuma spp.; Zingiberaceae; turmeric tuber; inflammation;
   curcumin
ID NF-KAPPA-B; TUMOR-NECROSIS-FACTOR; DIET-INDUCED OBESITY; ADIPOSE-TISSUE;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; ACTIVATED MACROPHAGES;
   LIPID-ACCUMULATION; 3T3-L1 ADIPOCYTES; HEPATIC STEATOSIS
AB Background: Obesity in the 21st century society became an important health problem, alarming both the scientists and medicine doctors around the world. That is why, the search for new drug candidates capable to reduce the body weight is of high concern.
   Objective: This contribution tends to collect current findings on the biochemistry of obesity and on the application of plants and in particular turmeric tuber - a commonly used spice - as an anti-obesity agent.
   Methods: Following an introduction on the biochemical characteristics of obesity, the description of Curcuma secondary metabolites, their pharmacological applications and a study on the plants' regulatory properties in obesity was summarized. Particular attention was paid to curcumin - the major metabolite present in the extracts of Curcuma spp., which is known to exhibit a variety of pharmacological actions. Also, the characteristics of some semisynthetic analogues of this ferulic acid derivative, characterized by a higher polarity and better bioavailability will be discussed.
   Results: Numerous scientific papers treat on the influence of turmeric on weight loss. Additionally, some of them describe its anti-inflammatory properties.
   Conclusions: This important spice tends to fight the 21st century plague, which is an excessive weight gain, related to the development of metabolic syndrome, to the occurrence of cardiovascular problems and diabetes, and, in consequence, leading to a significant shortening of life span. As herein proven, the extracts of turmeric play an important role in the regulation of inflammatory reactions which are evoked in the overweight patients, helping them reduce the excess body weight.
C1 [Jarzab, Agata] Med Univ Lublin, Dept Biochem & Mol Biol, 1 Chodzki Str, PL-20093 Lublin, Poland.
   [Kukula-Koch, Wirginia] Med Univ Lublin, Dept Pharmacognosy, Med Plants Unit, 1 Chodzki Str, PL-20093 Lublin, Poland.
C3 Medical University of Lublin; Medical University of Lublin
RP Kukula-Koch, W (corresponding author), Med Univ Lublin, Dept Pharmacognosy, Med Plants Unit, 1 Chodzki Str, PL-20093 Lublin, Poland.
EM virginia.kukula@gmail.com
RI Kukula-Koch, Wirginia/I-5468-2019
OI Jarzab, Agata/0000-0001-8670-8613; Kukula-Koch,
   Wirginia/0000-0001-7076-600X
FU Polish National Center of Science [2015/17/D/NZ7/00822]
FX The study was supported by the Polish National Center of Science,
   project No 2015/17/D/NZ7/00822.
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NR 127
TC 7
Z9 7
U1 0
U2 14
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 0929-8673
EI 1875-533X
J9 CURR MED CHEM
JI Curr. Med. Chem.
PY 2018
VL 25
IS 37
BP 4837
EP 4853
DI 10.2174/0929867324666161118095443
PG 17
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Pharmacology &
   Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
GA HH8MT
UT WOS:000455987000003
PM 27855627
DA 2025-06-11
ER

PT J
AU Crispo, A
   Augustin, LSA
   Grimaldi, M
   Nocerino, F
   Giudice, A
   Cavalcanti, E
   Di Bonito, M
   Botti, G
   De Laurentiis, M
   Rinaldo, M
   Esposito, E
   Riccardi, G
   Amore, A
   Libra, M
   Ciliberto, G
   Jenkins, DJA
   Montella, M
AF Crispo, A.
   Augustin, L. S. A.
   Grimaldi, M.
   Nocerino, F.
   Giudice, A.
   Cavalcanti, E.
   Di Bonito, M.
   Botti, G.
   De laurentiis, M.
   Rinaldo, M.
   Esposito, E.
   Riccardi, G.
   Amore, A.
   Libra, M.
   Ciliberto, G.
   Jenkins, D. J. A.
   Montella, M.
TI Risk Differences Between Prediabetes And Diabetes According To Breast
   Cancer Molecular Subtypes
SO JOURNAL OF CELLULAR PHYSIOLOGY
LA English
DT Article
ID GLYCEMIC INDEX; CARDIOVASCULAR RISK; MEDITERRANEAN DIET; METABOLIC
   SYNDROME; OXIDATIVE STRESS; PLASMA-GLUCOSE; INSULIN; METFORMIN;
   RECEPTOR; MELLITUS
AB Hyperglycemia and hyperinsulinemia may play a role in breast carcinogenesis and prediabetes and diabetes have been associated with increased breast cancer (BC) risk. However, whether BC molecular subtypes may modify these associations is less clear. We therefore investigated these associations in all cases and by BC molecular subtypes among women living in Southern Italy. Cases were 557 patients with non-metastatic incident BC and controls were 592 outpatients enrolled during the same period as cases and in the same hospital for skin-related non-malignant conditions. Adjusted multivariate logistic regression models were built to assess the risks of developing BC in the presence of prediabetes or diabetes. The analyses were repeated by strata of BC molecular subtypes: Luminal A, Luminal B, HER2+, and Triple Negative (TN). Prediabetes and diabetes were significantly associated with higher BC incidence after controlling for known risk factors (OR = 1.94, 95% CI 1.32-2.87 and OR = 2.46, 95% CI 1.38-4.37, respectively). Similar results were seen in Luminal A and B while in the TN subtype only prediabetes was associated with BC (OR = 2.43, 95% CI 1.11-5.32). Among HER2+ patients, only diabetes was significantly associated with BC risk (OR = 3.04, 95% CI 1.24-7.47). Furthermore, when postmenopausal HER2+ was split into hormone receptor positive versus negative, the association with diabetes remained significant only in the former (OR = 5.13, 95% CI 1.53-17.22). These results suggest that prediabetes and diabetes are strongly associated with BC incidence and that these metabolic conditions may be more relevant in the presence of breast cancer molecular subtypes with positive hormone receptors. (C) 2016 Wiley Periodicals, Inc.
C1 [Crispo, A.; Augustin, L. S. A.; Grimaldi, M.; Nocerino, F.; Giudice, A.; Montella, M.] G Pascal Fdn, Natl Canc Inst, Epidemiol Unit, Naples, Italy.
   [Augustin, L. S. A.; Jenkins, D. J. A.] St Michaels Hosp, Clin Nutr & Risk Factor Modificat Ctr, Toronto, ON, Canada.
   [Cavalcanti, E.; Di Bonito, M.; Botti, G.] G Pascale Fdn, Natl Canc Ctr, Dept Diagnost Pathol & Lab, Naples, Italy.
   [De laurentiis, M.; Rinaldo, M.; Esposito, E.] G Pascale Fdn, Natl Canc Ctr, Dept Breast Surg, Naples, Italy.
   [Esposito, E.; Riccardi, G.] Univ Naples Federico II, Dept Clin Med & Surg, Naples, Italy.
   [Amore, A.] G Pascale Fdn, Natl Canc Ctr, Dept Surg, Naples, Italy.
   [Ciliberto, G.] Univ Catania, Dept Biomed & Biotechnol Sci, Sect Clin & Gen Pathol & Oncol, Catania, Italy.
   [Jenkins, D. J. A.] G Pascale Fdn, Natl Canc Inst, Sci Direct, Naples, Italy.
C3 IRCCS Fondazione Pascale; University of Toronto; Saint Michaels Hospital
   Toronto; IRCCS Fondazione Pascale; IRCCS Fondazione Pascale; University
   of Naples Federico II; IRCCS Fondazione Pascale; University of Catania;
   IRCCS Fondazione Pascale
RP Crispo, A (corresponding author), G Pascal Fdn, Natl Canc Inst, Via Mariano Semmola 52, I-80131 Naples, Italy.
EM anna.crispo@tin.it
RI Augustin, Livia/AAC-9009-2022; Esposito, Emanuela/AAG-8280-2019; De
   Laurentiis, Michelino/AAC-6321-2022; Jenkins, David/N-3090-2017; Libra,
   Massimo/ABF-6654-2020; Crispo, Anna/ABA-7435-2020; Rinaldo,
   Massimo/AAA-8913-2020; DE LAURENTIIS, Michelino/K-4934-2018; Ciliberto,
   Gennaro/J-4131-2017
OI Rinaldo, Massimo/0000-0001-8609-1182; Augustin, Livia Silvia
   Adriana/0000-0002-6673-8281; Botti, Gerardo/0000-0002-6287-733X; Amore,
   Alfonso/0000-0002-4568-2848; Cantile, Monica/0000-0001-7840-3369; Maria,
   Grimaldi/0000-0002-5332-7969; DE LAURENTIIS,
   Michelino/0000-0001-9009-1572; Ciliberto, Gennaro/0000-0003-2851-8605;
   Crispo, Anna/0000-0002-8455-3328
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NR 54
TC 12
Z9 13
U1 0
U2 39
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0021-9541
EI 1097-4652
J9 J CELL PHYSIOL
JI J. Cell. Physiol.
PD MAY
PY 2017
VL 232
IS 5
BP 1144
EP 1150
DI 10.1002/jcp.25579
PG 7
WC Cell Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Physiology
GA EP0IR
UT WOS:000397071100027
PM 27579809
DA 2025-06-11
ER

PT J
AU Kawamoto, R
   Katoh, T
   Ninomiya, D
   Kumagi, T
   Abe, M
   Kohara, K
AF Kawamoto, Ryuichi
   Katoh, Takeaki
   Ninomiya, Daisuke
   Kumagi, Teru
   Abe, Masanori
   Kohara, Katsuhiko
TI Synergistic association of changes in serum uric acid and triglycerides
   with changes in insulin resistance after walking exercise in
   community-dwelling older women
SO ENDOCRINE RESEARCH
LA English
DT Article
DE Synergism; serum uric acid; triglycerides; insulin resistance; walking
   exercise
ID METABOLIC SYNDROME; PHYSICAL-ACTIVITY; NORDIC WALKING; CARDIOVASCULAR
   RISK; OXIDATIVE STRESS; PRIMARY GOUT; HYPERTRIGLYCERIDEMIA; OBESITY;
   HYPERURICEMIA; HYPERTENSION
AB Introduction: Serum uric acid (SUA) and triglyceride (TG) levels are strongly correlated with insulin resistance; however, the association after a walking exercise program in community-dwelling older women has not been investigated. Methods: The present study included 100 postmenopausal women (mean +/- standard deviation, 68 +/- 7 years) from a rural village in Japan. The Nordic walking program of 120 min per week was performed for 12 weeks. Before and after the intervention, SUA, TG, various relevant factors and homeostasis model assessment of insulin resistance (HOMA-IR) were measured. Results and conclusions: Multivariate linear regression analysis showed that baseline TG and -glutamyltransferase (GGT) were significantly associated with baseline HOMA-IR. After the 12-week training program, changes in TG, SUA and GGT were significantly associated with changes in HOMA-IR. In addition to their direct associations, we observed a synergistic association between changes in TG and SUA and changes in HOMA-IR. Participants were divided into three groups (tertiles) according to changes in TG and SUA. The tertiles of changes in SUA correlated significantly with changes in HOMA-IR in participants in the tertile with the greatest decrease in TG (r = 0.525, p = 0.001), but not in the other two tertiles of change in TG (r = 0.049, p = 0.699). There was a significant interaction between SUA and TG for changes in HOMA-IR ( = 0.281, p = 0.005). These results suggest that changes in TG and SUA are synergistic factors associated with changes in insulin resistance after a 12-week walking exercise program in community-dwelling older women.
C1 [Kawamoto, Ryuichi; Ninomiya, Daisuke; Kumagi, Teru; Abe, Masanori] Ehime Univ, Grad Sch Med, Dept Community Med, 9-53 Nomura,Nomura Cho, Seiyo, Ehime 7971212, Japan.
   [Katoh, Takeaki; Kohara, Katsuhiko] Ehime Univ, Grad Sch Med, Dept Geriatr Med, Seiyo, Ehime 7971212, Japan.
RP Kawamoto, R (corresponding author), Ehime Univ, Grad Sch Med, Dept Community Med, 9-53 Nomura,Nomura Cho, Seiyo, Ehime 7971212, Japan.
EM rykawamo@m.ehime-u.ac.jp
RI Kumagi, Teru/AAS-7427-2021
OI Kumagi, Teru/0000-0002-2292-7750
FU Foundation for Development of Community
FX The authors declare that they have no competing interests. This work was
   supported in part by a grant-in-aid for Scientific Research from the
   Foundation for Development of Community (2014).
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NR 47
TC 11
Z9 11
U1 0
U2 9
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 0743-5800
EI 1532-4206
J9 ENDOCR RES
JI Endocr. Res.
PD MAY
PY 2016
VL 41
IS 2
BP 116
EP 123
DI 10.3109/07435800.2015.1094085
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA DL7XW
UT WOS:000375854700007
PM 26727147
DA 2025-06-11
ER

PT J
AU Wang, X
   Wu, H
   Long, Z
   Sun, QG
   Liu, JZ
   Liu, Y
   Hai, CX
AF Wang, Xin
   Wu, Hao
   Long, Zi
   Sun, Quangui
   Liu, Jiangzheng
   Liu, Ying
   Hai, Chunxu
TI Differential effect of Se on insulin resistance: regulation of
   adipogenesis and lipolysis
SO MOLECULAR AND CELLULAR BIOCHEMISTRY
LA English
DT Article
DE Selenium; Insulin resistance; High-fat diet; Adipocyte differentiation;
   Lipolysis
ID ACTIVATED-RECEPTOR-GAMMA; ADIPOCYTE DIFFERENTIATION; SELENOPROTEIN-P;
   METABOLIC SYNDROME; OXIDATIVE STRESS; SERUM SELENIUM; OBESITY;
   EXPRESSION; REPRESSION; BIOLOGY
AB Insulin resistance is the characteristic of type 2 diabetes mellitus and metabolic disorder. The biological effect of selenium (Se) on insulin sensitivity and metabolic function was contradictory. In this study, we designed two animal protocols to investigate the effect of physiological Se on high-fat (HF) diet-induced insulin resistance in mice and examined the influence of Se on adipocyte differentiation and lipolysis in isolated bone marrow stromal stem cells. The results showed that pre-treatment with Se, mimicking thiazolidinediones, increased adipocyte differentiation and fat deposit in adipose tissue and reduced ectopic lipid content and consequent ROS generation and mitochondrial dysfunction in livers, protecting against HF diet-induced insulin resistance. Post-treatment with Se promoted lipolysis in adipose tissue and ectopic lipid accumulation in livers and aggravated subsequent ROS generation and mitochondrial dysfunction, exacerbating insulin resistance induced by HF diet. Activation of GPx1 and Sepp1 was responsible for Se-exhibited bi-directional significance, which was at the crossroad of the biological effect of Se, leading to differential directions: one way is to accelerate mitotic clonal expansion and increase key regulators of adipocyte differentiation, such as PPAR gamma and C/EBP alpha/beta, leading to enhancement of adipogenic differentiation; the other way is to activate PKA/HSL pathway, reinforcing lipolysis. Further studies are needed to elucidate the mechanism underlying GPx1 and Sepp1-exerted differential effects under different conditions. Anyhow, these findings may partly explain the contradiction of the biological significance of Se and demonstrate a novel understanding of the mechanism of Se-exerted benefit or harmful effects in the context of high consumption of fat.
C1 [Wang, Xin; Wu, Hao; Liu, Jiangzheng; Liu, Ying; Hai, Chunxu] Fourth Mil Med Univ, Minist Educ,Key Lab Hazard Assessment & Control S, Sch Publ Hlth, Dept Toxicol,Shaanxi Key Lab Free Radical Biol &, Changle West Rd 169, Xian 710032, Peoples R China.
   [Long, Zi; Sun, Quangui] Fourth Mil Med Univ, Brigade Student 1, Xian 710032, Shaanxi, Peoples R China.
C3 Air Force Medical University; Ministry of Education - China; Air Force
   Medical University
RP Wang, X; Hai, CX (corresponding author), Fourth Mil Med Univ, Minist Educ,Key Lab Hazard Assessment & Control S, Sch Publ Hlth, Dept Toxicol,Shaanxi Key Lab Free Radical Biol &, Changle West Rd 169, Xian 710032, Peoples R China.
EM xinwang@fmmu.edu.cn; cx-hai@fmmu.edu.cn
RI Wang, Xin/AAJ-6869-2020; LONG, Zihao/MNO-3646-2025; Wang,
   Xin/S-5548-2016
OI Wang, Xin/0000-0002-7296-9406
FU National Natural Science Foundation of China [31400724]; Natural Science
   Foundation of Shaanxi Province [2014JQ4135]
FX This work was supported by National Natural Science Foundation of China
   (No. 31400724) and Natural Science Foundation of Shaanxi Province
   (2014JQ4135).
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NR 46
TC 13
Z9 14
U1 0
U2 24
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0300-8177
EI 1573-4919
J9 MOL CELL BIOCHEM
JI Mol. Cell. Biochem.
PD APR
PY 2016
VL 415
IS 1-2
BP 89
EP 102
DI 10.1007/s11010-016-2679-0
PG 14
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA DI6LI
UT WOS:000373610000008
PM 26961368
DA 2025-06-11
ER

PT J
AU Liu, C
   Zhong, R
   Lou, J
   Pan, A
   Tang, YH
   Chang, J
   Ke, JT
   Li, JY
   Yuan, J
   Wang, YJ
   Chen, WH
   Guo, H
   Wei, S
   Liang, Y
   Zhang, XM
   He, MA
   Hu, FB
   Wu, TC
   Yao, P
   Miao, XP
AF Liu, Cheng
   Zhong, Rong
   Lou, Jiao
   Pan, An
   Tang, Yuhan
   Chang, Jiang
   Ke, Juntao
   Li, Jiaoyuan
   Yuan, Jing
   Wang, Youjie
   Chen, Weihong
   Guo, Huan
   Wei, Sheng
   Liang, Yuan
   Zhang, Xiaomin
   He, Meian
   Hu, Frank B.
   Wu, Tangchun
   Yao, Ping
   Miao, Xiaoping
TI Nighttime sleep duration and risk of nonalcoholic fatty liver disease:
   the Dongfeng-Tongji prospective study
SO ANNALS OF MEDICINE
LA English
DT Article
DE Cohort study; nighttime sleep duration; nonalcoholic fatty liver
   disease; risk factor
ID INSULIN-RESISTANCE; CARDIOVASCULAR OUTCOMES; CONFERS SUSCEPTIBILITY;
   SEDENTARY BEHAVIOR; METABOLIC SYNDROME; OXIDATIVE STRESS; UNITED-STATES;
   LEPTIN LEVELS; METAANALYSIS; ASSOCIATION
AB Background: To examine the association between self-reported nighttime sleep duration and nonalcoholic fatty liver disease (NAFLD) risk by comparing the incidence rates of NAFLD among healthy subjects with different sleep duration during the 5 years follow-up.Methods: 8965 eligible NAFLD-free subjects with a mean age of 61.6 years (males, 43.4%) from Dongfeng-Tongji cohort study at baseline were enrolled in the study. Logistic regression analysis was used to estimate the association between sleep duration and incident NAFLD with potential confounders adjusted. Sleep duration was categorized into five groups:<6h, 6-7h, 7-8h, 8-9h,9h.Result: During the 5-years of follow-up, a total of 2,197 participants were newly diagnosed as NAFLD. Compared with those reported 7-8h per day of nighttime sleep, the multivariable-adjusted odds ratio (95% confidence intervals) were 1.21 (1.07-1.38) for those who sleep 8-9h/day, and 1.31 (1.13-1.52) for those who sleep over 9h/day. However, no significant association was found with short nightly sleep duration (<7h/day).Conclusion: Long nighttime sleep duration was associated with a modestly increased risk of NAFLD in a middle-aged and elderly Chinese population.Key messagesLong nighttime sleep duration was associated with a modestly increased risk of NAFLD in a middle-aged and elderly Chinese population.The effect of long nighttime sleep on the risk of incident NAFLD was attenuated greatly by body mass index (BMI) in men.
C1 [Liu, Cheng; Zhong, Rong; Lou, Jiao; Pan, An; Ke, Juntao; Li, Jiaoyuan; Wei, Sheng; Miao, Xiaoping] Huazhong Univ Sci & Technol, Sch Publ Hlth, Dept Epidemiol & Stat, Tongji Med Coll, Wuhan, Peoples R China.
   [Liu, Cheng; Zhong, Rong; Lou, Jiao; Pan, An; Tang, Yuhan; Chang, Jiang; Ke, Juntao; Li, Jiaoyuan; Yuan, Jing; Wang, Youjie; Chen, Weihong; Guo, Huan; Wei, Sheng; Liang, Yuan; Zhang, Xiaomin; He, Meian; Wu, Tangchun; Yao, Ping; Miao, Xiaoping] Huazhong Univ Sci & Technol, Sch Publ Hlth, Tongji Med Coll, MOE,Key Lab Environm & Hlth, 13 Hangkong Rd, Wuhan 430030, Peoples R China.
   [Tang, Yuhan; Yao, Ping] Huazhong Univ Sci & Technol, Sch Publ Hlth, Tongji Med Coll, Dept Nutr & Food Hyg,Hubei Key Lab Food Nutr & Sa, Wuhan, Peoples R China.
   [Yuan, Jing; Chen, Weihong; Guo, Huan; Zhang, Xiaomin; He, Meian; Wu, Tangchun] Huazhong Univ Sci & Technol, Sch Publ Hlth, Tongji Med Coll, Dept Occupat & Environm Hlth, Wuhan, Peoples R China.
   [Hu, Frank B.] Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA.
   [Hu, Frank B.] Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA.
C3 Huazhong University of Science & Technology; Huazhong University of
   Science & Technology; Huazhong University of Science & Technology;
   Huazhong University of Science & Technology; Harvard University; Harvard
   T.H. Chan School of Public Health; Harvard University; Harvard T.H. Chan
   School of Public Health
RP Yao, P (corresponding author), Huazhong Univ Sci & Technol, Sch Publ Hlth, Tongji Med Coll, MOE,Key Lab Environm & Hlth, 13 Hangkong Rd, Wuhan 430030, Peoples R China.; Miao, XP (corresponding author), Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Dept Epidemiol & Biostat, 13 Hangkong Rd, Wuhan 430030, Peoples R China.
EM yaoping@mails.tjmu.edu.cn; miaoxp@mail.hust.edu.cn
RI Chen, Weihong/D-2177-2011; Liu, Haocheng/HLG-7944-2023; Zhang,
   Xiaomin/F-3206-2018; Hu, Frank/C-1919-2013; li, yan/GXH-7943-2022; wei,
   sheng/E-9746-2012; 李, 娇元/GVS-6952-2022; Zhong, Rong/Q-1813-2019; miao,
   xiaoping/C-4336-2011; Pan, An/C-5572-2011
OI miao, xiaoping/0000-0002-6818-9722; Pan, An/0000-0002-1089-7945; Zhong,
   Rong/0000-0002-5060-895X
FU 111 Project [B12004]; Program for Changjiang Scholars, Innovative
   Research Team in University of Ministry of Education of China [IRT1246]
FX This work was supported by grants from the 111 Project (No. B12004), the
   Program for Changjiang Scholars, Innovative Research Team in University
   of Ministry of Education of China (No. IRT1246) for Tangchun Wu and
   National Program for Support of Top-notch Young Professionals for
   Xiaoping Miao.
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NR 53
TC 25
Z9 31
U1 1
U2 16
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0785-3890
EI 1365-2060
J9 ANN MED
JI Ann. Med.
PY 2016
VL 48
IS 6
BP 468
EP 476
DI 10.1080/07853890.2016.1193787
PG 9
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA DZ2KL
UT WOS:000385670600009
PM 27327959
DA 2025-06-11
ER

PT J
AU Martínez, AC
   Hernández, M
   Novella, S
   Martínez, MP
   Pagán, RM
   Hermenegildo, C
   García-Sacristán, A
   Prieto, D
   Benedito, S
AF Cristina Martinez, Ana
   Hernandez, Medardo
   Novella, Susana
   Pilar Martinez, Maria
   Maria Pagan, Rosa
   Hermenegildo, Carlos
   Garcia-Sacristan, Albino
   Prieto, Dolores
   Benedito, Sara
TI Diminished Neurogenic Femoral Artery Vasoconstrictor Response in a
   Zucker Obese Rat Model: Differential Regulation of NOS and COX
   Derivatives
SO PLOS ONE
LA English
DT Article
ID VASCULAR SMOOTH-MUSCLE; ENDOTHELIAL DYSFUNCTION; OXIDATIVE STRESS;
   PENILE ARTERIES; NORADRENERGIC VASOCONSTRICTION; CARDIOVASCULAR-SYSTEM;
   MESENTERIC-ARTERIES; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   BLOOD-PRESSURE
AB Objective: Peripheral arterial disease is one of the macrovascular complications of type 2 diabetes mellitus. This study addresses femoral artery regulation in a prediabetic model of obese Zucker rats (OZR) by examining cross-talk between endothelial and neural factors.
   Methods and Results: Arterial preparations from lean (LZR) and OZR were subjected to electrical field stimulation (EFS) on basal tone. Nitric oxide synthase (NOS) and cyclooxygenase (COX) isoform expression patterns were determined by immunohistochemical labelling and Western blotting. Results indicate significantly reduced noradrenergic contractions in preparations from OZR compared with those of LZR. Functional inhibition of endothelial NOS (eNOS) indicated a predominant role of this isoform in LZR and its modified activity in OZR. Neural (nNOS) and inducible NOS (iNOS) were activated and their expression was higher in femoral arteries from OZR. Neurotransmission modulated by large-conductance Ca2+-activated (BKCa) or voltage-dependent (K-V) K+ channels did not seem compromised in the obese animals. Endothelial COX-1 and COX-2 were expressed in LZR and an additional adventitial location of COX-2 was also observed in OZR, explaining the higher COX-2 protein levels detected in this group. Prostanoids derived from both isoforms helped maintain vasoconstriction in LZR while in OZR only COX-2 was active. Superoxide anion inhibition reduced contractions in endothelium-intact arteries from OZR.
   Conclusions: Endothelial dysfunction led to reduced neurogenic vasoconstriction in femoral arteries from OZR. In a setting of obesity, NO-dependent nNOS and iNOS dilation activity could be an alternative mechanism to offset COX-2- and reactive oxygen species-mediated vasoconstriction, along with impaired endothelial NO relaxation.
C1 [Cristina Martinez, Ana; Hernandez, Medardo; Maria Pagan, Rosa; Garcia-Sacristan, Albino; Prieto, Dolores; Benedito, Sara] Univ Complutense Madrid, Fac Farm, Dept Fisiol, Madrid, Spain.
   [Novella, Susana; Hermenegildo, Carlos] Univ Valencia, Fac Med, Dept Fisiol, Valencia, Spain.
   [Pilar Martinez, Maria] Univ Complutense Madrid, Fac Vet, Dept Anat & Anat Patol Comparadas, Madrid, Spain.
C3 Complutense University of Madrid; University of Valencia; Complutense
   University of Madrid
RP Benedito, S (corresponding author), Univ Complutense Madrid, Fac Farm, Dept Fisiol, Madrid, Spain.
EM sbenedi@ucm.es
RI Hermenegildo, Carlos/C-5995-2008; Novella, Susana/A-7406-2017; PRIETO,
   DOLORES/S-8172-2018; BENEDITO, SARA/H-9730-2015; Martinez, Ana
   Cristina/H-9795-2015; Martinez, Pilar/E-8591-2016
OI Novella, Susana/0000-0001-8303-7252; PRIETO,
   DOLORES/0000-0001-7049-5991; BENEDITO, SARA/0000-0001-9660-2409;
   Hermenegildo, Carlos/0000-0002-4015-2645; Martinez, Ana
   Cristina/0000-0002-2829-0914; Martinez, Pilar/0000-0001-9063-3191
FU Ministerio de Economia y Competitividad (Spain) [SAF2009-10448, SAF
   2012-31631]
FX This study was supported by grant SAF2009-10448 and SAF 2012-31631 from
   Ministerio de Economia y Competitividad (Spain)
   (http://www.mineco.gob.es/). Authors who received the funding include DP
   (lead researcher), ACM and SB. The funders had no role in study design,
   data collection and analysis, decision to publish, or preparation of the
   manuscript.
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NR 45
TC 9
Z9 10
U1 0
U2 8
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD SEP 12
PY 2014
VL 9
IS 9
AR e106372
DI 10.1371/journal.pone.0106372
PG 17
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA AP0SM
UT WOS:000341774300010
PM 25216050
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Jung, S
   Kim, OY
   Kim, M
   Song, J
   Lee, SH
   Lee, JH
AF Jung, Saem
   Kim, Oh Yoen
   Kim, Minjoo
   Song, Juheui
   Lee, Sang-Hyun
   Lee, Jong Ho
TI Age-Related Increase in Alanine Aminotransferase Correlates with
   Elevated Levels of Plasma Amino Acids, Decanoylcarnitine,
   Lp-PLA2 Activity, Oxidative Stress, and Arterial Stiffness
SO JOURNAL OF PROTEOME RESEARCH
LA English
DT Article
DE Plasma metabolites; alanine aminotransferase; aspartate
   aminotransferase; L-valine; L-leucine; L-phenylalanine;
   decanoylcarnitine; cardiovascular risk factors; Lp-PLA(2); arterial
   stiffness
ID FATTY LIVER-DISEASE; METABOLIC SYNDROME; PHOSPHOLIPASE A(2); RISK;
   ENZYMES; HEART; OBESE; ATHEROSCLEROSIS; ASSOCIATION
AB We investigated plasma metabolite profiles that correlated with age-related serum alanine aminotransferase (ALT) levels. The study included 602 healthy, nondiabetic subjects (aged 30-65 years); 393 individuals had normal ALT levels at baseline. Fifty-three (13.5%) individuals developed elevated ALT levels after 3 years. The remaining 340 subjects with normal ALT were matched to the elevated-ALT group (n = 53) for age, gender, BMI, fasting glucose, and ALT to form the control group (n = 53). At the 3-year follow-up, the elevated-ALT group exhibited greater increases in waist circumference, serum free fatty acid, ALT, aspartate aminotransferase (AST), gamma-glutamyltransferase (GGT), bilirubin, plasma oxidized LDL, Lp-PLA(2) activity, urinary 8-epi-prostaglandin F-2 alpha (8-epi-PGF(2 alpha)), and brachial-ankle pulse-wave velocity (ba-PWV) compared to the control group after baseline adjustment. The elevated-ALT group exhibited greater increases in plasma L-valine (q = 0.036), L-leucine (q = 0.012), L-phenylalanine (q = 0.012), and decanoylcamitine (q = 0.002). Mean ALT levels positively correlated with changes in these four metabolites, which correlated with changes in AST, GGT, Lp-PLA(2) activity, urinary 8-epi-PGF(2 alpha), and ba-PWV. Mean ALT changes did not significantly correlate with HOMA-insulin resistance. These results suggest that increased plasma levels of L-valine, L-leucine, L-phenylalanine, and decanoylcamitine precede insulin resistance during periods of elevated ALT. This metabolic disturbance coincides with enhanced risk factors for cardiovascular disease.
C1 [Jung, Saem; Kim, Minjoo; Song, Juheui; Lee, Jong Ho] Yonsei Univ, Coll Human Ecol, Dept Food & Nutr, Natl Leading Res Lab Clin Nutrigenet Nutrigen, Seoul 120749, South Korea.
   [Jung, Saem; Kim, Minjoo; Song, Juheui; Lee, Jong Ho] Yonsei Univ, Coll Human Ecol, Dept Food & Nutr, Brain Korea PLUS Project 21, Seoul 120749, South Korea.
   [Kim, Oh Yoen] Dong A Univ, Dept Food Sci & Nutr, Pusan 604714, South Korea.
   [Lee, Sang-Hyun] Natl Hlth Insurance Corp Ilsan Hosp, Dept Family Practice, Goyang 410719, South Korea.
C3 Yonsei University; Yonsei University; Dong A University
RP Lee, JH (corresponding author), Yonsei Univ, Coll Human Ecol, Dept Food & Nutr, Natl Leading Res Lab Clin Nutrigenet Nutrigen, Seoul 120749, South Korea.
EM jhleeb@yonsei.ac.kr
RI Kim, Minjoo/AEN-5516-2022; Kim, Oh/AAA-6492-2022; Lee,
   Sang-Hyun/ABR-3363-2022
FU National Research Foundation (NRF) - Ministry of Science, ICT & Future
   Planning, Republic of Korea [NRF-2006-2005306, NRF-2012M3A9C4048762,
   NRF-2010-0015017]
FX The authors thank the research volunteers who participated in the
   studies described in this article. We also thank the technical
   assistants of Yonsei Center for Research Facilities, Yonsei University,
   for assistance with the LC-MS [LTQ-Orbitrap (micro-LC)] analyses. This
   research was supported by the Bio & Medical Technology Development
   Program (NRF-2006-2005306 and NRF-2012M3A9C4048762) and Mid-Career
   Researcher Program (NRF-2010-0015017) of the National Research
   Foundation (NRF) funded by the Ministry of Science, ICT & Future
   Planning, Republic of Korea.
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NR 35
TC 18
Z9 18
U1 0
U2 7
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1535-3893
EI 1535-3907
J9 J PROTEOME RES
JI J. Proteome Res.
PD JUL
PY 2014
VL 13
IS 7
BP 3467
EP 3475
DI 10.1021/pr500422z
PG 9
WC Biochemical Research Methods
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA AK8QP
UT WOS:000338693400030
PM 24874467
DA 2025-06-11
ER

PT J
AU Nguyen, D
   Samson, SL
   Reddy, VT
   Gonzalez, EV
   Sekhar, RV
AF Nguyen, Dan
   Samson, Susan L.
   Reddy, Vasumathi T.
   Gonzalez, Erica V.
   Sekhar, Rajagopal V.
TI Impaired mitochondrial fatty acid oxidation and insulin resistance in
   aging: novel protective role of glutathione
SO AGING CELL
LA English
DT Article
DE aging; fuel oxidation; glutathione; insulin resistance; mitochondria
ID RAT SKELETAL-MUSCLE; GLUCOSE-TOLERANCE; CARBOHYDRATE OXIDATION;
   METABOLIC SYNDROME; SUBUNIT GENE; US ADULTS; OBESITY; STRESS; DEPLETION;
   AGE
AB Aging is associated with impaired fasted oxidation of nonesterified fatty acids (NEFA) suggesting a mitochondrial defect. Aging is also associated with deficiency of glutathione (GSH), an important mitochondrial antioxidant, and with insulin resistance. This study tested whether GSH deficiency in aging contributes to impaired mitochondrial NEFA oxidation and insulin resistance, and whether GSH restoration reverses these defects. Three studies were conducted: (i) in 82-week-old C57BL/6 mice, the effect of naturally occurring GSH deficiency and its restoration on mitochondrial 13C1-palmitate oxidation and glucose metabolism was compared with 22-week-old C57BL/6 mice; (ii) in 20-week C57BL/6 mice, the effect of GSH depletion on mitochondrial oxidation of 13C1-palmitate and glucose metabolism was studied; (iii) the effect of GSH deficiency and its restoration on fasted NEFA oxidation and insulin resistance was studied in GSH-deficient elderly humans, and compared with GSH-replete young humans. Chronic GSH deficiency in old mice and elderly humans was associated with decreased fasted mitochondrial NEFA oxidation and insulin resistance, and these defects were reversed with GSH restoration. Acute depletion of GSH in young mice resulted in lower mitochondrial NEFA oxidation, but did not alter glucose metabolism. These data suggest that GSH is a novel regulator of mitochondrial NEFA oxidation and insulin resistance in aging. Chronic GSH deficiency promotes impaired NEFA oxidation and insulin resistance, and GSH restoration reverses these defects. Supplementing diets of elderly humans with cysteine and glycine to correct GSH deficiency could provide significant metabolic benefits.
C1 [Nguyen, Dan; Sekhar, Rajagopal V.] Baylor Coll Med, Translat Metab Unit, Div Diabet Endocrinol & Metab, Houston, TX 77030 USA.
   [Nguyen, Dan; Samson, Susan L.; Reddy, Vasumathi T.; Gonzalez, Erica V.; Sekhar, Rajagopal V.] Baylor Coll Med, Diabet Res Ctr, Dept Med, Houston, TX 77030 USA.
C3 Baylor College of Medicine; Baylor College of Medicine
RP Sekhar, RV (corresponding author), Baylor Coll Med, Translat Metab Unit, Div Diabet Endocrinol & Metab, BCM 185,Alkek Bldg Biomed Res,1 Baylor Plaza, Houston, TX 77030 USA.
EM rsekhar@bcm.tmc.edu
FU Baylor College of Medicine Faculty Seed Award; Baylor College of
   Medicine Alkek Bridge fund; Baylor College of Medicine General Clinical
   Research Center [NIH RR-0188]; NIH-Diabetes and Endocrinology Research
   Center [NIH-P30DK079638]; American Diabetes Association Junior Faculty
   award; Baylor College of Medicine
FX This study was supported by the Baylor College of Medicine Faculty Seed
   Award and the Baylor College of Medicine Alkek Bridge fund (to RVS), the
   Baylor College of Medicine General Clinical Research Center (NIH
   RR-0188), and the NIH-Diabetes and Endocrinology Research Center
   (NIH-P30DK079638). SS is supported by an American Diabetes Association
   Junior Faculty award and receives funds from the Baylor College of
   Medicine Alkek Bridge fund. We thank the Baylor adult GCRC nursing staff
   for adherence to the protocols in the human study. None of the authors
   have any conflicts of interest to report.
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NR 45
TC 79
Z9 92
U1 1
U2 28
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1474-9726
J9 AGING CELL
JI Aging Cell
PD JUN
PY 2013
VL 12
IS 3
BP 415
EP 425
DI 10.1111/acel.12073
PG 11
WC Cell Biology; Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Geriatrics & Gerontology
GA 142ON
UT WOS:000318806900009
PM 23534396
OA hybrid
DA 2025-06-11
ER

PT J
AU Doyle, L
   MacKay-Lyons, M
AF Doyle, Lindsay
   MacKay-Lyons, Marilyn
TI Utilization of Aerobic Exercise in Adult Neurological Rehabilitation by
   Physical Therapists in Canada
SO JOURNAL OF NEUROLOGIC PHYSICAL THERAPY
LA English
DT Article
DE aerobic exercise; clinical practice; neurological conditions;
   rehabilitation
ID QUALITY-OF-LIFE; SPINAL-CORD-INJURY; MULTIPLE-SCLEROSIS; PRESCRIBING
   EXERCISE; METABOLIC SYNDROME; STROKE; INDIVIDUALS; INTENSITY; CAPACITY;
   FATIGUE
AB Background and Purpose: Although aerobic exercise (AE) has been shown to improve aerobic capacity and reduce morbidity in neurological populations, its application is challenging. The purpose of this study was to survey Canadian physical therapists practicing in adult neurorehabilitation regarding the use of AE in clinical practice.
   Methods: Members of the Neurosciences Division of the Canadian Physiotherapy Association were invited to participate in a Web-based survey.
   Results: Response rate was 36% (N = 155) with every Canadian province represented. The majority of respondents were females in full-time practice for more than 15 years. The majority (88%) agreed/strongly agreed with the following: "AE should be incorporated into treatment programs of patients with neurological conditions." Although 77% prescribed AE, barriers to use included patient concerns (cardiac status, cognitive/perceptual deficits, fatigue) and operations (lack of staff, time, screening tools). The most commonly used screening tools were health records and patient responses to exercise and the least common was exercise stress tests. Over-ground walking and cycle ergometry were the most frequently used AE modes, and general response to exercise and patient feedback were most frequently used for determining exercise intensity and monitoring AE.
   Discussion and Conclusions: Respondents clearly recognized the importance of AE in neurorehabilitation. Barriers to application of AE and limitations in the use of appropriate screening and training procedures need to be addressed to advance clinical utilization of AE in neurological practice. Understanding current patterns of utilization of AE is important for the development of professional education initiatives and clinical guidelines for best practices in AE for neurological populations.
C1 [Doyle, Lindsay] Queen Elizabeth Hosp, Charlottetown, PE, Canada.
   [MacKay-Lyons, Marilyn] Dalhousie Univ, Sch Physiotherapy, Halifax, NS B3H 4R2, Canada.
C3 Dalhousie University
RP MacKay-Lyons, M (corresponding author), Dalhousie Univ, Sch Physiotherapy, Halifax, NS B3H 4R2, Canada.
EM m.mackay-lyons@dal.ca
OI MacKay-Lyons, Marilyn/0000-0002-9917-3117
CR [Anonymous], 2011, PHYS CAN 2010 NAT JU
   [Anonymous], 2010, ACSMS GUIDELINES EXE
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NR 48
TC 53
Z9 56
U1 0
U2 23
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1557-0576
EI 1557-0584
J9 J NEUROL PHYS THER
JI J. Neurol. Phys. Ther.
PD MAR
PY 2013
VL 37
IS 1
BP 20
EP 26
DI 10.1097/NPT.0b013e318282975c
PG 7
WC Clinical Neurology; Rehabilitation
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Rehabilitation
GA 107LA
UT WOS:000316217200005
PM 23389387
OA Bronze
DA 2025-06-11
ER

PT J
AU Shankar, A
   Xiao, J
   Ducatman, A
AF Shankar, Anoop
   Xiao, Jie
   Ducatman, Alan
TI Perfluorooctanoic Acid and Cardiovascular Disease in US Adults
SO ARCHIVES OF INTERNAL MEDICINE
LA English
DT Article
ID CORONARY-HEART-DISEASE; NUTRITION EXAMINATION SURVEY; OXIDATIVE STRESS;
   LIVER-ENZYMES; SERUM-LIPIDS; METABOLIC SYNDROME; NATIONAL-HEALTH; RISK;
   SULFONATE; ASSOCIATION
AB Background: Cardiovascular disease (CVD) is a major public health problem. Identifying novel risk factors for CVD, including widely prevalent environmental exposures, is therefore important. Perfluorooctanoic acid (PFOA) is a manmade chemical used in the manufacture of common household consumer products. Biomonitoring surveys have shown that PFOA is detectable in the blood of more than 98% of the US population. Experimental animal studies suggest that an association between PFOA and CVD is plausible. However, this association in humans has not been previously examined. We therefore examined the independent relationship between serum PFOA levels and CVD outcomes in a representative sample of Americans.
   Methods: We examined 1216 subjects (51.2% women) from the 1999-2003 National Health and Nutritional Examination Survey. Serum PFOA levels were examined in quartiles. The main outcomes of interest were self-reported CVD, including coronary heart disease and stroke, and objectively measured peripheral arterial disease (PAD), defined as an ankle-brachial blood pressure index of less than 0.9.
   Results: We found that increasing serum PFOA levels are positively associated with CVD and PAD, independent of confounders such as age, sex, race/ethnicity, smoking status, body mass index, diabetes mellitus, hypertension, and serum cholesterol level. Compared with quartile 1 (reference) of PFOA level, the multivariable odds ratio (95% CI) among subjects in quartile 4 was 2.01 (1.12-3.60; P = .01 for trend) for CVD and 1.78 (1.03-3.08; P = .04 for trend) for PAD.
   Conclusion: Exposure to PFOA is associated with CVD and PAD, independent of traditional cardiovascular risk factors.
C1 [Shankar, Anoop; Xiao, Jie; Ducatman, Alan] W Virginia Univ, Sch Publ Hlth, Dept Epidemiol, 1 Med Ctr Dr,POB 9190, Morgantown, WV 26506 USA.
C3 West Virginia University
RP Shankar, A (corresponding author), W Virginia Univ, Sch Publ Hlth, Dept Epidemiol, 1 Med Ctr Dr,POB 9190, Morgantown, WV 26506 USA.
EM ashankar@hsc.wvu.edu
RI Ducatman, Alan/J-9813-2019
OI Ducatman, Alan/0000-0002-9446-0459
FU American Heart Association; National Institute of Environmental Health
   Sciences, National Institutes of Health [R01 ES021825-01,
   5R03ES018888-02]
FX This study was supported by a National Clinical Research Program grant
   from the American Heart Association (Dr Shankar) and grants R01
   ES021825-01 and 5R03ES018888-02 from the National Institute of
   Environmental Health Sciences, National Institutes of Health (Dr
   Shankar).
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NR 56
TC 79
Z9 89
U1 3
U2 52
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 0003-9926
EI 1538-3679
J9 ARCH INTERN MED
JI Arch. Intern. Med.
PD OCT 8
PY 2012
VL 172
IS 18
BP 1397
EP 1403
DI 10.1001/archinternmed.2012.3393
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 016ST
UT WOS:000309540500006
PM 22945282
DA 2025-06-11
ER

PT J
AU Su, Y
   Lei, X
   Wu, LY
   Liu, LX
AF Su, Yang
   Lei, Xi
   Wu, Lingyun
   Liu, Lixin
TI The role of endothelial cell adhesion molecules P-selectin, E-selectin
   and intercellular adhesion molecule-1 in leucocyte recruitment induced
   by exogenous methylglyoxal
SO IMMUNOLOGY
LA English
DT Article
DE adhesion molecules; endothelial cells; leucocyte recruitment;
   methylglyoxal; nuclear factor-?B
ID DIABETIC VASCULAR COMPLICATIONS; OXIDATIVE STRESS; CIRCULATING LEVELS;
   CARBONYL-COMPOUNDS; METABOLIC SYNDROME; MAP KINASE; P38 MAPK;
   INFLAMMATION; NEPHROPATHY; ACTIVATION
AB Methylglyoxal (MG) is a reactive dicarbonyl metabolite formed during glucose, protein and fatty acid metabolism. In hyperglycaemic conditions, increased MG level has been linked to the development of diabetes and its vascular complications at the macrovascular and microvascular levels where inflammation plays a role. To study the mechanism of MG-induced inflammation in vivo, we applied MG locally to healthy mice and used intravital microscopy to investigate the role of endothelial cell adhesion molecules in MG-induced leucocyte recruitment in cremasteric microvasculature. Administration of MG (25 and 50 mg/kg) to the tissue dose-dependently induced leucocyte recruitment at 4.0-5.5 hr, with 84-92% recruited cells being neutrophils. Such MG treatment up-regulated the expression of endothelial cell adhesion molecules P-selectin, E-selectin, intercellular adhesion molecule-1, but not vascular cell adhesion molecule-1. Activation of the nuclear factor-kappa B signalling pathway contributed to MG-induced up-regulation of these adhesion molecules and leucocyte recruitment. The role of the up-regulated endothelial cell adhesion molecules in MG-induced leucocyte recruitment was determined by applying specific functional blocking antibodies to MG-treated animals and observing changes in leucocyte recruitment parameters. Our data demonstrate that the up-regulation of P-selectin, E-selectin and intercellular adhesion molecule-1 contributes to the increased leucocyte rolling flux, reduced leucocyte rolling velocity, and increased leucocyte adhesion, respectively. Our results reveal the role of endothelial cell adhesion molecules in MG-induced leucocyte recruitment in microvasculature, an inflammatory condition related to diabetic vascular complications.
C1 [Su, Yang; Lei, Xi; Wu, Lingyun; Liu, Lixin] Univ Saskatchewan, Coll Med, Dept Pharmacol, Saskatoon, SK S7N 5E5, Canada.
C3 University of Saskatchewan
RP Liu, LX (corresponding author), Univ Saskatchewan, Coll Med, Dept Pharmacol, 107 Wiggins Rd, Saskatoon, SK S7N 5E5, Canada.
EM lixin.liu@usask.ca
RI Liu, Lixin/KIK-9732-2024; Wu, Lingyun/HRD-0014-2023
FU Canadian Institutes of Health Research (CIHR); China Scholarship Council
FX The authors thank Arlene Drimmie and Karen Yuen for their expert
   technical help in histology and immunohistochemistry experiments. This
   work is supported by a research grant to L. Liu from the Canadian
   Institutes of Health Research (CIHR). L. Liu is a recipient of a CIHR
   New Investigator Award. Y. Su is supported by a scholarship from the
   China Scholarship Council.
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NR 54
TC 53
Z9 59
U1 0
U2 10
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0019-2805
EI 1365-2567
J9 IMMUNOLOGY
JI Immunology
PD SEP
PY 2012
VL 137
IS 1
BP 65
EP 79
DI 10.1111/j.1365-2567.2012.03608.x
PG 15
WC Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology
GA 982VT
UT WOS:000307074200007
PM 22681228
OA Green Published
DA 2025-06-11
ER

PT J
AU Kim, B
   McLean, LL
   Philip, SS
   Feldman, EL
AF Kim, Bhumsoo
   McLean, Lisa L.
   Philip, Stephen S.
   Feldman, Eva L.
TI Hyperinsulinemia Induces Insulin Resistance in Dorsal Root Ganglion
   Neurons
SO ENDOCRINOLOGY
LA English
DT Article
ID HUMAN SKELETAL-MUSCLE; OXIDATIVE STRESS; PHOSPHATIDYLINOSITOL 3-KINASE;
   DIABETIC-NEUROPATHY; MITOCHONDRIAL DYSFUNCTION; RECEPTOR SUBSTRATE-1;
   SIGNALING PATHWAYS; SENSORY NEURONS; PHOSPHORYLATION; AKT
AB Insulin resistance (IR) is the major feature of metabolic syndrome, including type 2 diabetes. IR studies are mainly focused on peripheral tissues, such as muscle and liver. There is, however, little knowledge about IR in neurons. In this study, we examined whether neurons develop IR in response to hyperinsulinemia. We first examined insulin signaling using adult dorsal root ganglion neurons as a model system. Acute insulin treatment resulted in time- and concentration-dependent activation of the signaling cascade, including phosphorylation of the insulin receptor, Akt, p70S6K, and glycogen synthase kinase-3 beta. To mimic hyperinsulinemia, cells were pretreated with 20 nM insulin for 24 h and then stimulated with 20 nM insulin for 15 min. Chronic insulin treatment resulted in increased basal Akt phosphorylation. More importantly, acute insulin stimulation after chronic insulin treatment resulted in blunted phosphorylation of Akt, p70S6K, and glycogen synthase kinase-3 beta. Interestingly, when the cells were treated with phosphatidylinositol 3-kinase pathway inhibitor, but not MAPK pathway inhibitor, chronic insulin treatment did not block acute insulin treatment-induced Akt phosphorylation. Insulin-induced Akt phosphorylation was lower in dorsal root ganglion neurons from BKS-db/db compared with control BKS-db+ mice. This effect was age dependent. Our results suggest that hyperinsulinemia cause IR by disrupting the Akt-mediated pathway. We also demonstrate that hyperinsulinemia increases the mitochondrial fission protein dynamin-related protein 1. Our results suggest a new theory for the etiology of diabetic neuropathy, i.e. that, similar to insulin dependent tissues, neurons develop IR and, in turn, cannot respond to the neurotrophic properties of insulin, resulting in neuronal injury and the development of neuropathy. (Endocrinology 152: 3638-3647, 2011)
C1 [Kim, Bhumsoo; McLean, Lisa L.; Philip, Stephen S.; Feldman, Eva L.] Univ Michigan, Dept Neurol, Ann Arbor, MI 48109 USA.
C3 University of Michigan System; University of Michigan
RP Kim, B (corresponding author), Univ Michigan, Dept Neurol, 109 Zina Pitcher Pl,5371 BSRB, Ann Arbor, MI 48109 USA.
EM bhumsoo@umich.edu
OI Feldman, Eva/0000-0002-9162-2694; Philip, Stephen/0000-0003-4205-3787
FU National Institutes of Health [UO1 DK076160, R24 DK082840-01]; Program
   for Neurology Research and Discovery
FX This work was supported by National Institutes of Health Grants UO1
   DK076160 and R24 DK082840-01 and by the Program for Neurology Research
   and Discovery.
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NR 59
TC 84
Z9 103
U1 2
U2 11
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0013-7227
EI 1945-7170
J9 ENDOCRINOLOGY
JI Endocrinology
PD OCT
PY 2011
VL 152
IS 10
BP 3638
EP 3647
DI 10.1210/en.2011-0029
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 822WN
UT WOS:000295081200009
PM 21810948
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU de Souza, MO
   Silva, M
   Silva, ME
   Oliveira, RD
   Pedrosa, ML
AF de Souza, Melina Oliveira
   Silva, Maisa
   Silva, Marcelo Eustaquio
   Oliveira, Riva de Paula
   Pedrosa, Maria Lucia
TI Diet supplementation with acai (Euterpe oleracea Mart.) pulp
   improves biomarkers of oxidative stress and the serum lipid profile in
   rats
SO NUTRITION
LA English
DT Article
DE Euterpe oleracea; Acai; Antioxidant status; Hypocholesterolemic effect;
   Rats
ID AMAZONIAN PALM BERRY; IRON OVERLOAD; GREEN TEA; METABOLIC SYNDROME;
   DISEASE; PLASMA; ATHEROSCLEROSIS; CONSUMPTION; LDL; ANTHOCYANINS
AB Objective: We investigated the antioxidant potential and hypocholesterolemic effects of acai (Euterpe oleracea Mart.) pulp ingestion in rats fed a standard or hypercholesterolemic diet.
   Methods: Female Fischer rats were fed a standard AIN-93 M diet (control) or a hypercholesterolemic diet that contained 25% soy oil and 1% cholesterol. The test diet was supplemented with 2% acai pulp (dry wt/wt) for control (group CA) and hypercholesterolemic rats (group HA) for 6 wk. At the end of the experimental period, rats were sacrificed and the blood and livers were collected. To evaluate the effect of acai consumption, levels of protein carbonyl and sulfhydryl groups, superoxide dismutase and paraoxonase activities, and lipid profiles of the sera were measured.
   Results: Animals that were fed the hypercholesterolemic diet presented increased levels of total and non-high-density lipoprotein cholesterol and decreased levels of high-density lipoprotein cholesterol. Supplementing the diet of this group with acai caused a hypocholesterolemic effect by reducing total and non-high-density lipoprotein cholesterol. Serum levels of carbonyl proteins and total, free, and protein sulfhydryl groups were reduced by acai ingestion in animals receiving the standard or hypercholesterolemic diet. Acai supplementation induced a significant reduction in superoxide dismutase activity only in the hypercholesterolemic rats, indicating an association between diet and acai treatment. Also, acai supplementation increased paraoxonase activity in the CA and HA groups.
   Conclusion: These results suggest that the consumption of acai improves antioxidant status and has a hypocholesterolemic effect in an animal model of dietary-induced hypercholesterolemia. (C) 2010 Elsevier Inc. All rights reserved.
C1 [de Souza, Melina Oliveira; Silva, Maisa; Silva, Marcelo Eustaquio; Oliveira, Riva de Paula; Pedrosa, Maria Lucia] Univ Fed Ouro Preto, Nucleo Pesquisas Ciencias Biol, Ouro Preto, MG, Brazil.
   [Silva, Marcelo Eustaquio] Univ Fed Ouro Preto, Dept Alimentos, Ouro Preto, MG, Brazil.
   [Oliveira, Riva de Paula; Pedrosa, Maria Lucia] Univ Fed Ouro Preto, Dept Ciencias Biol, Ouro Preto, MG, Brazil.
C3 Universidade Federal de Ouro Preto; Universidade Federal de Ouro Preto;
   Universidade Federal de Ouro Preto
RP Pedrosa, ML (corresponding author), Univ Fed Ouro Preto, Nucleo Pesquisas Ciencias Biol, Ouro Preto, MG, Brazil.
EM lpedrosa@nupeb.ufop.br
RI Silva, Maria/JXM-0158-2024; Mussury, Rosilda/B-3075-2013; de Paula
   Oliveira, Riva/LFR-6833-2024
OI Oliveira, Riva/0000-0002-4917-7646; Silva, Maisa/0000-0003-3996-159X; de
   Paula Oliveira, Riva/0000-0002-6092-6142
FU Fundacao de Amparo A Pesquisa de Minas Gerais (FAPEMIG, Minas Gerais,
   Brazil); Conselho Nacional de Desenvolvimento Cientifico e Tecnologico
   (CNPq, Brazil) [475823/2007-9]
FX This study was supported by the Fundacao de Amparo A Pesquisa de Minas
   Gerais (FAPEMIG, Minas Gerais, Brazil) and Conselho Nacional de
   Desenvolvimento Cientifico e Tecnologico (CNPq, Brazil; no.
   475823/2007-9).
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NR 52
TC 97
Z9 102
U1 0
U2 33
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0899-9007
EI 1873-1244
J9 NUTRITION
JI Nutrition
PD JUL-AUG
PY 2010
VL 26
IS 7-8
BP 804
EP 810
DI 10.1016/j.nut.2009.09.007
PG 7
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 619UF
UT WOS:000279455100020
PM 20022468
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Han, SS
   Na, KY
   Chae, DW
   Kim, YS
   Kim, S
   Chin, HJ
AF Han, Seung Seok
   Na, Ki Young
   Chae, Dong-Wan
   Kim, Yon Su
   Kim, Suhnggwon
   Chin, Ho Jun
TI High Serum Bilirubin Is Associated with the Reduced Risk of Diabetes
   Mellitus and Diabetic Nephropathy
SO TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE
LA English
DT Article
DE bilirubin; chronic kidney disease; diabetes mellitus; diabetic
   nephropathy; metabolic syndrome
ID NUTRITION EXAMINATION SURVEY; GENOME-WIDE ASSOCIATION; STAGE
   RENAL-DISEASE; NATIONAL-HEALTH; BILIVERDIN REDUCTASE; OXIDATIVE STRESS;
   HEME OXYGENASE-2; SEX-DIFFERENCES; CELL; GENE
AB Several studies have suggested a potential effect of serum bilirubin as an antioxidant and cytoprotectant factor. For the results presented here, we evaluated the correlation between serum bilirubin and diabetes mellitus (DM) or chronic kidney disease originated from DM (DMCKD) in a Korean population. We used a cross-sectional, population-based design to examine 93,909 subjects (aged 18-96 years, 53.0% male). The trend of P values in the odds ratios for being DM and DMCKD was calculated using patients separated into five groups based on individual serum bilirubin concentrations. The prevalence of DM and DMCKD was 6.7% and 0.8%, respectively. Higher serum bilirubin levels were significantly associated with decreased prevalence of DM in both men (P trend < 0.001) and women (P trend = 0.014). The risk of DMCKD also decreased as bilirubin levels increased in women (P trend = 0.011), but not in men (P trend = 0.467). Serum bilirubin level was inversely related to insulin resistance using the homeostasis model assessment (HOMA-IR), serum insulin, and C-reactive protein (CRP) levels in multiple linear regression analyses. The regression coefficients (B) of log-HOMA-IR, log-insulin, and log-CRP were as follows: -0.09, -0.13, and -0.60 in men; -0.07, -0.09, and -0.50 in women, respectively. All the regressions were statistically significant (P < 0.001). These results indicate that serum bilirubin might have some protective function against DM and DMCKD, although the association between high serum bilirubin and decreased prevalence of DMCKD is observed only in women.
C1 [Na, Ki Young; Chae, Dong-Wan; Chin, Ho Jun] Seoul Natl Univ, Bundang Hosp, Dept Internal Med, Songnam 463707, Gyeonggi Do, South Korea.
   [Han, Seung Seok; Na, Ki Young; Chae, Dong-Wan; Kim, Yon Su; Kim, Suhnggwon; Chin, Ho Jun] Seoul Natl Univ, Coll Med, Dept Internal Med, Seoul 151, South Korea.
   [Chae, Dong-Wan; Kim, Yon Su; Kim, Suhnggwon; Chin, Ho Jun] Seoul Natl Univ, Coll Med, Kidney Res Inst, Seoul 151, South Korea.
C3 Seoul National University (SNU); Seoul National University (SNU); Seoul
   National University (SNU)
RP Chin, HJ (corresponding author), Seoul Natl Univ, Bundang Hosp, Dept Internal Med, Gumi Dong 300, Songnam 463707, Gyeonggi Do, South Korea.
EM mednep@snubh.org
RI Kim, Suhnggwon/J-5407-2012; Chin, Ho/J-5678-2012; Na, Ki/J-5456-2012;
   Han, Seung Seok/HGD-2825-2022; Chae, Dong-Wan/J-5681-2012; Kim,
   Yon/J-2743-2012
FU Seoul National University Hospital Research Fund [21-2004-001-0]
FX This study was supported by the grant (No. 21-2004-001-0) from the Seoul
   National University Hospital Research Fund.
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NR 30
TC 93
Z9 101
U1 0
U2 9
PU TOHOKU UNIV MEDICAL PRESS
PI SENDAI
PA 2-1, SEIRYO-MACHI, AOBA-KU, SENDAI, MIYAGI 980-8575, JAPAN
SN 0040-8727
EI 1349-3329
J9 TOHOKU J EXP MED
JI Tohoku J. Exp. Med.
PD JUN
PY 2010
VL 221
IS 2
BP 133
EP 140
DI 10.1620/tjem.221.133
PG 8
WC Medicine, General & Internal; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Research & Experimental Medicine
GA 604OT
UT WOS:000278289100007
PM 20495302
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Bengmark, S
AF Bengmark, Stig
TI Advanced glycation and lipoxidation end products-amplifiers of
   inflammation: The role of food
SO JOURNAL OF PARENTERAL AND ENTERAL NUTRITION
LA English
DT Review
ID COWS MILK CONSUMPTION; STAGE RENAL-DISEASE; OXIDATIVE STRESS; DIETARY
   GLYCOTOXINS; METABOLIC SYNDROME; PROTEIN GLYCATION; DIABETES-MELLITUS;
   MAILLARD REACTION; DOWN-REGULATION; NONENZYMATIC GLYCATION
AB Background: High levels of glycated and lipoxidated proteins and peptides in the body are repeatedly associated with chronic diseases. These molecules are strongly associated with activation of a specific receptor called RAGE and a long-lasting exaggerated level of inflammation in the body. Methods: PubMed reports over 5000 papers plus >13,500 articles about the related HbA(1c), most of them published in, the past 5 years. Most of the available abstracts have been read and approximately 800 full papers have been studied. Results: RAGE, a member of the immunoglobulin superfamily of cell surface molecules and receptor for advanced glycation end, products, known since 1992, functions as a master switch, induces, sustained activation of nuclear factor kappa B (NF kappa B), suppresses a series of endogenous autoregulatory functions, and converts long-lasting proinflammatory signals into sustained cellular dysfunction and disease. Its activation is associated with high levels of dysfunctioning proteins in body fluids and tissues, and is strongly associated with a series of diseases from allergy and Alzheimers to rheumatoid arthritis and urogenital disorders. Heat treatment, irradiation, and ionization of foods increase the content of dysfunctioning molecules. Conclusions: More than half of the studies are performed in diabetes and chronic renal diseases; there are few studies in other diseases. Most of our knowledge is based on animal studies and in vitro studies. These effects are worth further exploration both experimentally and clinically. An avoidance of foods rich in deranged proteins and peptides, and the consumption of antioxidants, especially polyphenols, seem to counteract such a development.
C1 UCL, Sch Med, Inst Hepatol, London W1N 8AA, England.
C3 University of London; University College London; UCL Medical School
RP Bengmark, S (corresponding author), 185 Barrier Point Rd,Royal Docks, London E16 2SE, England.
OI Bengmark, Stig/0000-0003-1809-8889
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NR 162
TC 65
Z9 76
U1 0
U2 29
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0148-6071
EI 1941-2444
J9 JPEN-PARENTER ENTER
JI J. Parenter. Enter. Nutr.
PD SEP-OCT
PY 2007
VL 31
IS 5
BP 430
EP 440
DI 10.1177/0148607107031005430
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 206ID
UT WOS:000249176200023
PM 17712153
DA 2025-06-11
ER

PT J
AU El-Molla, AM
   Fetouh, FA
   Bawazir, S
   Alwahby, YA
   Ali, YA
   Basseet, AA
   Albanna, AH
AF El-Molla, Ashraf M.
   Fetouh, Fawzia Aboul
   Bawazir, Samir
   Alwahby, Yehya A.
   Ali, Yasser A.
   Basseet, Abdullah A.
   Albanna, Ahmed Hassan
TI Epinephrine as a Therapeutic Agent for Hyperferritinemia in Diabetes
   Mellitus and Hypertension
SO AMERICAN JOURNAL OF CASE REPORTS
LA English
DT Article
DE Epinephrine; Ferritins; Diabetes Mellitus
ID INSULIN-RESISTANCE; SERUM FERRITIN; OXIDATIVE STRESS; METABOLIC
   SYNDROME; IRON-METABOLISM; BLOOD-PRESSURE; ACTIVATION; ADRENALINE;
   HYPERINSULINEMIA; ASSOCIATION
AB Objective: Unusual clinical course Background: Diabetes mellitus was the first non-communicable disease to be recognized as a 21st century pandemic. Type 2 diabetes (T2DM) results from increased insulin resistance (IR) or relative insulin deficiency. IR impairs glucose disposal, leading to a compensatory hyper-insulinemic state. Increased iron stores as reflected by high serum ferritin (SF) have been associated with the development T2DM and affect glucose homeostasis by impairing tissue response to insulin. Iron overload (IO) is quite common in essential hypertension (HTN). The first clinical effect of epinephrine on SF was reported in 2024, showing that epinephrine resulted in normalization of SF and recovery from severe COVID-19 infection. Case Report: A patient with T2DM, HTN, and dyslipidemia associated with hyperferritinemia received the conventional treatment of T2DM and HTN, with a poor control of hyperglycemia and HTN. Since the patient had elevated SF, we obtained informed written consent for epinephrine's use to lower SF. Epinephrine 0.6 mcg/kg was injected subcutaneously under hemodynamic monitoring, and the results showed normalization of SF and complete recovery of T2DM and HTN. Conclusions: Epinephrine can normalize elevated SF by its iron chelating effect; therefore, it can relieve IO and alleviate IR associated with T2DM and HTN. Epinephrine has an anti-inflammatory and scavenging properties that can inhibit ferroptosis. As a new clinical indication, extensive studies are required for further assessment and possible therapeutic uses in IO disorders such as hereditary hemochromatosis (HH), Alzheimer disease (AD), Parkinsonian disease (PD), and multiple sclerosis (MS).
C1 [El-Molla, Ashraf M.] Al Kawkab Hosp, Dept Anesthesiol & Intens Care Therapy, Cairo, Egypt.
   [Fetouh, Fawzia Aboul] Misr Univ Sci & Technol, Dept Anesthesiol, Cairo, Egypt.
   [Bawazir, Samir] Prince Sultan Mil Med City, Pediat Div, Dept Otolaryngol Head & Neck Surg, Riyadh, Saudi Arabia.
   [Alwahby, Yehya A.; Basseet, Abdullah A.] King Fahd Med City, Anaesthesia Dept, Riyadh, Saudi Arabia.
   [Alwahby, Yehya A.; Albanna, Ahmed Hassan] Prince Sultan Mil Med City, Dept Anaesthesia, Riyadh, Saudi Arabia.
C3 Egyptian Knowledge Bank (EKB); Misr University for Science & Technology;
   Prince Sultan Military Medical City; King Fahad Medical City; Prince
   Sultan Military Medical City
RP El-Molla, AM (corresponding author), Al Kawkab Hosp, Dept Anesthesiol & Intens Care Therapy, Cairo, Egypt.
EM aosj244@yahoo.com
RI Ali, Yasser/GSJ-1000-2022
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NR 76
TC 0
Z9 0
U1 0
U2 0
PU INT SCIENTIFIC INFORMATION, INC
PI MELVILLE
PA 150 BROADHOLLOW RD, STE 114, MELVILLE, NY 11747 USA
EI 1941-5923
J9 AM J CASE REP
JI Am. J. Case Rep.
PD APR 20
PY 2025
VL 26
AR e947289
DI 10.12659/AJCR.947289
PG 8
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA 1SQ8F
UT WOS:001472711600001
PM 40253583
DA 2025-06-11
ER

PT J
AU Malliaras, P
   Silbernagel, KG
   de Vos, RJ
   Bourke, J
   Sancho, I
   Hanlon, SL
   Agergaard, AS
   Bahr, R
   Bittencourt, NFN
   Bordalo, M
   Brorsson, A
   Brown, VT
   Cardoso, T
   Child, S
   Chimenti, RL
   Cowley, E
   D'Hooghe, P
   Derman, W
   Finnoff, JT
   Fu, SN
   Halstead, J
   Hamilton, B
   Nilsson-Helander, KM
   Hölmich, P
   Houghton, J
   James, AM
   Kulig, K
   Lau, A
   Ling, SM
   Maffulli, N
   Masci, L
   Mayes, S
   Mc Auliffe, S
   McCrum, C
   Morrissey, D
   Munteanu, SE
   Murphy, MC
   Newsham-West, R
   O'Neill, S
   Padhiar, N
   Papadopoulou, T
   Rees, JD
   Rio, EK
   Ruffino, D
   Scott, A
   Speirs, S
   Sun, Y
   Thorborg, K
   Trease, L
   Verhaar, JAN
   Wezenbeek, E
   White, S
   Zellers, JA
   Zhang, S
   Korakakis, V
   Vicenzino, B
AF Malliaras, Peter
   Gravare Silbernagel, Karin
   de Vos, Robert-Jan
   Bourke, Jaryd
   Sancho, Igor
   Hanlon, Shawn L.
   Agergaard, Anne-Sofie
   Bahr, Roald
   Bittencourt, Natalia Franco Netto
   Bordalo, Marcelo
   Brorsson, Annelie
   Tzortziou Brown, Victoria
   Cardoso, Tanusha
   Child, Sally
   Chimenti, Ruth L.
   Cowley, Emma
   D'Hooghe, Pieter
   Derman, Wayne
   Finnoff, Jonathan T.
   Fu, Siu Ngor
   Halstead, Jill
   Hamilton, Bruce
   Nilsson-Helander, Katarina Maria
   Holmich, Per
   Houghton, Jonathan
   James, Alicia M.
   Kulig, Kornelia
   Lau, Amanda
   Ling, Samuel
   Maffulli, Nicola
   Masci, Lorenzo
   Mayes, Sue
   Mc Auliffe, Sean
   Mccrum, Carol
   Morrissey, Dylan
   Munteanu, Shannon E.
   Murphy, Myles Calder
   Newsham-West, Richard
   O'Neill, Seth
   Padhiar, Nat
   Papadopoulou, Theodora
   Rees, Jonathan D.
   Rio, Ebonie Kendra
   Ruffino, Diego
   Scott, Alex
   Speirs, Suzy
   Sun, Yang
   Thorborg, Kristian
   Trease, Larissa
   Verhaar, Jan A. N.
   Wezenbeek, Evi
   White, Sue
   Zellers, Jennifer A.
   Zhang, S.
   Korakakis, Vasileios
   Vicenzino, Bill
TI Diagnostic domains, differential diagnosis and conditions requiring
   further medical attention that are considered important in the
   assessment for Achilles tendinopathy: a Delphi consensus study
SO BRITISH JOURNAL OF SPORTS MEDICINE
LA English
DT Article; Early Access
DE Diagnosis; Achilles Tendon; Tendinopathy; Consensus
ID QUALITATIVE CONTENT-ANALYSIS; PAIN; RISK
AB The absence of agreed methods to diagnose Achilles tendinopathy impedes research and clinical practice. This gap results in heterogeneous and/or poorly described study samples, making it challenging to apply findings in clinical practice. The aim of this Delphi study was to define consensus on (1) diagnostic domains; (2) differential diagnoses; and (3) conditions requiring further medical attention, when assessing for Achilles tendinopathy.
   We conducted a sequential three-stage process which included: (1) identifying diagnostic domains, differential diagnoses and conditions requiring further medical attention based on existing scoping reviews and clinical practice guidelines; (2) developing Delphi survey questions; and (3) administering a five-round Delphi online survey. Consensus was defined as >= 70% agreement.
   52 participants completed the surveys. Four diagnostic domains were deemed essential and reached consensus (pain location (93%); pain during activity (97%); tests that provoke pain (87%); palpation to assess pain (83%)). 15 differential diagnoses reached consensus: 2 for both midportion and insertional (partial tear (80%); posterior ankle impingement (78%)), 6 for midportion (plantaris tendinopathy (84%); tibialis posterior or flexor hallucis longus tendinopathy/tenosynovitis (72%); flexor digitorum longus tendinopathy (77%); accessory soleus muscle (74%); paratendinopathy (86%); sural nerve neuropathy (81%)) and 7 for insertional (superficial (88%) and retrocalcaneal bursitis (86%); Haglund's/calcaneal exostosis (80%), intratendinous calcifications (73%); Sever's disease (78%); calcaneal stress reaction/fracture (80%); subtalar/ankle pain (71%)). Six conditions requiring further medical attention reached consensus: (Achilles tendon rupture (83%); systemic inflammatory joint disease (86%); metabolic syndrome (75%); familial hypercholesterolaemia (77%); endocrine and hormonal disorders (80%); drug reactions (77%)). This consensus identified essential diagnostic domains, differential diagnoses and conditions requiring further medical attention that should be considered when assessing for Achilles tendinopathy.
C1 [Malliaras, Peter; Bourke, Jaryd] Monash Univ, Fac Med Nursing & Hlth Sci, Physiotherapy Dept, Melbourne, Vic, Australia.
   [Gravare Silbernagel, Karin] Univ Delaware, Dept Phys Therapy, Newark, DE USA.
   [de Vos, Robert-Jan] Erasmus MC, Dept Orthopaed & Sports Med, Rotterdam, Netherlands.
   [Sancho, Igor] Univ Deusto, Fac Hlth Sci, Phys Therapy Dept, Deusto Phys TherapIker Grp, Donostia San Sebastian, Spain.
   [Hanlon, Shawn L.] Calif State Univ Fullerton, Dept Kinesiol, Fullerton, CA USA.
   [Agergaard, Anne-Sofie] Copenhagen Univ Hosp Bispebjerg & Frederiksberg, Inst Sports Med Copenhagen, Dept Orthoped Surg, Copenhagen, Denmark.
   [Agergaard, Anne-Sofie] Copenhagen Univ Hosp Bispebjerg & Frederiksberg, Inst Sports Med Copenhagen, Dept Phys & Occupat Therapy, Copenhagen, Denmark.
   [Bahr, Roald] Norwegian Sch Sport Sci, Oslo Sports Trauma Res Ctr, Oslo, Norway.
   [Bittencourt, Natalia Franco Netto] Esporte Clube Bahia, Salvador, Brazil.
   [Bittencourt, Natalia Franco Netto] Univ Fed Minas Gerais, Soccer Sci Ctr, Belo Horizonte, MG, Brazil.
   [Bordalo, Marcelo] Aspetar Orthoped & Sports Med Hosp, Doha, Qatar.
   [Tzortziou Brown, Victoria] Queen Mary Univ London, Wolfson Inst Populat Hlth, London, England.
   [Cardoso, Tanusha] Alphington Sports Med, Northcote, Vic, Australia.
   [Child, Sally] Olymp Pk Sports Med Ctr, Melbourne, Vic, Australia.
   [Chimenti, Ruth L.] Univ Iowa, Dept Phys Therapy & Rehabil Sci, Iowa City, IA USA.
   [Cowley, Emma] Univ Southampton, Sch Hlth Sci, Southampton, England.
   [D'Hooghe, Pieter] Aspetar Orthopaed & Sports Med Hosp, Doha, Ad Dawhah, Qatar.
   [Derman, Wayne] Stellenbosch Univ, Dept Exercise Sport & Lifestyle Med, Inst Sport & Exercise Med ISEM, Fac Med & Hlth Sci, Tygerberg, South Africa.
   [Finnoff, Jonathan T.] United States Olymp & Paralymp Comm, Colorado Springs, CO USA.
   [Finnoff, Jonathan T.] Univ Colorado, Sch Med, Dept Phys Med & Rehabil, Denver, CO USA.
   [Fu, Siu Ngor] Hong Kong Polytech Univ, Dept Rehabil Sci, Hong Kong, Peoples R China.
   [Halstead, Jill] Leeds Community Healthcare NHS Trust, Leeds, England.
   [Halstead, Jill] Univ Leeds, Leeds Inst Rheumat & Musculoskeletal Med, Leeds, W Yorkshire, England.
   [Hamilton, Bruce] Auckland Univ Technol, High Performance Sport New Zealand, Auckland, New Zealand.
   [Nilsson-Helander, Katarina Maria] Sahlgrenska Univ Hosp Molndal, Inst Clin Sci, Sahlgrenska Acad, Dept Orthopaed, Gothenburg, Sweden.
   Copenhagen Univ Hosp, Sports Orthopaed Res Ctr Copenhagen SORC C, Arthroscop Ctr, Dept Orthoped Surg, Amager Hvidovre, Denmark.
   [Holmich, Per] Hvidovre Univ Hosp, Dept Orthopaed Surg, Hvidovre, Denmark.
   [Houghton, Jonathan; Rees, Jonathan D.] Fortius Clin, London, England.
   [James, Alicia M.] Peninsula Hlth, Podiatry, Frankston, Vic, Australia.
   [Kulig, Kornelia] Univ Southern Calif, Div Biokinesiol & Phys Therapy, Los Angeles, CA USA.
   [Lau, Amanda; Masci, Lorenzo] Inst Sport Exercise & Hlth, London, England.
   [Ling, Samuel] Chinese Univ Hong Kong, Dept Orthopaed & Traumatol, Ma Liu Shui, Hong Kong, Peoples R China.
   [Maffulli, Nicola] Univ Roma La Sapienza, Fac Med & Psychol, Dept Trauma & Orthopaed Surg, Rome, Italy.
   [Maffulli, Nicola] Barts & London Queen Marys Sch Med & Dent, Ctr Sports & Exercise Med, London, England.
   [Mayes, Sue; Newsham-West, Richard; Trease, Larissa] La Trobe Univ, La Trobe Sport & Exercise Med Res Ctr, Melbourne, Vic, Australia.
   [Mc Auliffe, Sean] Univ Limerick, Dept Physiotherapy, Limerick, Ireland.
   [Mccrum, Carol] Canberra Hlth Serv, Rheumatol Dept, Canberra, ACT, Australia.
   [Morrissey, Dylan] Queen Mary Univ London, Sport & Exercise Med, London, England.
   [Morrissey, Dylan] Barts Hlth NHS Trust, Physiotherapy Dept, London, England.
   [Munteanu, Shannon E.] La Trobe Univ, Sch Allied Hlth Human Serv & Sport, Discipline Podiatry, Melbourne, Vic, Australia.
   [Murphy, Myles Calder] Edith Cowan Univ, Nutr & Hlth Innovat Res Inst, Joondalup, WA, Australia.
   [O'Neill, Seth] Univ Leicester, Coll Life Sci, Sch Healthcare, Leicester, England.
   [Padhiar, Nat] Barts & London Queen Marys Sch Med & Dent, London, England.
   [Papadopoulou, Theodora] Stanford Hall Def Med Rehabil Ctr, Loughborough, England.
   [Rio, Ebonie Kendra] La Trobe Univ, La Trobe Sport & Exercise Med Res Ctr, Bundoora, Vic, Australia.
   [Ruffino, Diego] Univ Nacl Cordoba, Cordoba, Argentina.
   [Scott, Alex] Univ British Columbia, Phys Therapy, Vancouver Campus, Vancouver, BC, Canada.
   [Speirs, Suzy] One Welbeck Surg Ctr, London, England.
   [Sun, Yang] Fudan Univ, Dept Sports Med, Huashan Hosp, Shanghai, Peoples R China.
   [Thorborg, Kristian] Copenhagen Univ Hosp, Sports Orthopaed Res Ctr Copenhagen SORC C, Arthroscop Ctr, Dept Orthoped Surg, Amager Hvidovre, Denmark.
   [Thorborg, Kristian] Hvidovre Univ Hosp, Hvidovre, Denmark.
   [Verhaar, Jan A. N.] Erasmus MC, Dept Orthoped & Sports Med, Rotterdam, Netherlands.
   [Wezenbeek, Evi] Univ Antwerp, Rehabil Sci & Physiotherapy, Antwerp, Belgium.
   [White, Sue] Victorian Inst Sport, Albert Pk, VIC, Australia.
   [Zellers, Jennifer A.] Washington Univ, Sch Med St Louis, Program Phys Therapy, St Louis, MO USA.
   [Zhang, S.] Fudan Univ, Sports Med, Shanghai, Peoples R China.
   [Korakakis, Vasileios] Univ Nicosia, Dept Hlth Sci, Nicosia, Cyprus.
   [Vicenzino, Bill] Univ Queensland, Physiotherapy, Brisbane, Qld, Australia.
C3 Monash University; University of Delaware; Erasmus University Rotterdam;
   Erasmus MC; University of Deusto; California State University System;
   California State University Fullerton; University of Copenhagen;
   Bispebjerg Hospital; University of Copenhagen; Bispebjerg Hospital;
   Norwegian School of Sport Sciences; Universidade Federal de Minas
   Gerais; Aspetar Orthopaedic & Sports Medicine Hospital; University of
   London; Queen Mary University London; University of Iowa; University of
   Southampton; Aspetar Orthopaedic & Sports Medicine Hospital;
   Stellenbosch University; University of Colorado System; University of
   Colorado Anschutz Medical Campus; University of Colorado Denver; Hong
   Kong Polytechnic University; University of Leeds; Auckland University of
   Technology; Sahlgrenska University Hospital; University of Gothenburg;
   University of Copenhagen; Copenhagen University Hospital; University of
   Copenhagen; Peninsula Health; University of Southern California; Chinese
   University of Hong Kong; Sapienza University Rome; University of London;
   Queen Mary University London; La Trobe University; University of
   Limerick; University of London; Queen Mary University London; Barts
   Health NHS Trust; La Trobe University; Edith Cowan University;
   University of Leicester; University of London; Queen Mary University
   London; La Trobe University; National University of Cordoba; University
   of British Columbia; Fudan University; University of Copenhagen;
   Copenhagen University Hospital; University of Copenhagen; Erasmus
   University Rotterdam; Erasmus MC; University of Antwerp; Washington
   University (WUSTL); Saint Louis University; Fudan University; University
   of Nicosia; University of Queensland
RP Malliaras, P (corresponding author), Monash Univ, Fac Med Nursing & Hlth Sci, Physiotherapy Dept, Melbourne, Vic, Australia.
EM peter.malliaras@monash.edu; kgs@udel.edu; r.devos@erasmusmc.nl;
   jaryd.bourke@monash.edu; physioigorsancho@gmail.com; hanlon@udel.edu;
   Anne-Sofie.Agergaard@regionh.dk; roald@nih.no;
   nataliabittencourt@yahoo.com.br; marcelo.bordalo@aspetar.com;
   annelie.brorsson@orthop.gu.se; v.tzortzioubrown@qmul.ac.uk;
   tanushacardoso@gmail.com; sallychild@bigpond.com;
   ruthchimenti@gmail.com; E.E.Cowley@soton.ac.uk;
   Pieter.DHooghe@aspetar.com; ewderman@iafrica.com;
   jonathan.finnoff@usopc.org; amy.fu@polyu.edu.hk;
   jill.halstead-rastrick@nhs.net; bruce.hamilton@hpsnz.org.nz;
   ina.helander@gmail.com; holmich@webspeed.dk;
   Jonathan.Houghton@fortiusclinic.com; alicia@kingstonfootclinic.com.au;
   kulig@usc.edu; amanda@amandalaupodiatry.com;
   samuel.ling@link.cuhk.edu.hk; n.maffulli@qmul.ac.uk;
   lorenzo@sportdoctorlondon.com; SueM@australianballet.com.au;
   macca@live.ie; Carol.McCrum@act.gov.au; d.morrissey@qmul.ac.uk;
   s.munteanu@latrobe.edu.au; m.murphy@ecu.edu.au;
   richard.newshamwest@gmail.com; seth.oneill@leicester.ac.uk;
   n.padhiar@qmul.ac.uk; thpapadopoulou@hotmail.com;
   jon.rees@fortiusclinic.com; e.rio@latrobe.edu.au;
   licdiegoruffino@hotmail.com; alex.scott@ubc.ca; suzyspeirs@hotmail.com;
   sunyang@fudan.edu.cn; kristianthorborg@hotmail.com;
   dr.larissa.trease@gmail.com; j.verhaar@erasmusmc.nl;
   evi.wezenbeek@ugent.be; susan.white@vis.org.au; jzellers@wustl.edu;
   herpiglet@hotmail.com; vkorakakis@hotmail.com; b.vicenzino@uq.edu.au
RI Vicenzino, Bill/A-8492-2011; Brorsson, Annelie/AAD-5986-2020; Chimenti,
   Ruth/ABG-6616-2020; Derman, Wayne/ABD-6557-2020; Murphy,
   Myles/Q-8313-2017; Morrissey, Dylan/G-2226-2011; Rio,
   Ebonie/S-1962-2019; Trease, Larissa/AAO-2033-2021; Halstead,
   Jill/AFL-9151-2022; Bittencourt, Natalia/E-1949-2019; Hanlon,
   Shawn/HKF-6856-2023; Verhaar, Jan/AAH-1372-2020; Kulig,
   Kornelia/E-4931-2010; Sancho, Igor/LXU-4859-2024; Bordalo-Rodrigues,
   Marcelo/I-2157-2012; Ling, Samuel Ka-Kin/J-4270-2016
OI Hanlon, Shawn/0000-0002-5866-9853; Ling, Samuel
   Ka-Kin/0000-0003-4528-9074; de Vos, Robert-Jan/0000-0003-0372-0188
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NR 29
TC 1
Z9 1
U1 1
U2 1
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 0306-3674
EI 1473-0480
J9 BRIT J SPORT MED
JI Br. J. Sports Med.
PD 2025 APR 16
PY 2025
DI 10.1136/bjsports-2024-109185
EA APR 2025
PG 11
WC Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Sport Sciences
GA 1MX0J
UT WOS:001468810100001
PM 40240126
DA 2025-06-11
ER

PT J
AU Sowton, AP
   Holzner, LMW
   Krause, FN
   Baxter, R
   Mocciaro, G
   Krzyzanska, DK
   Minnion, M
   O'Brien, KA
   Harrop, MC
   Darwin, PM
   Thackray, BD
   Vacca, M
   Feelisch, M
   Griffin, JL
   Murray, AJ
AF Sowton, Alice P.
   Holzner, Lorenz M. W.
   Krause, Fynn N.
   Baxter, Ruby
   Mocciaro, Gabriele
   Krzyzanska, Dominika K.
   Minnion, Magdalena
   O'Brien, Katie A.
   Harrop, Matthew C.
   Darwin, Paula M.
   Thackray, Benjamin D.
   Vacca, Michele
   Feelisch, Martin
   Griffin, Julian L.
   Murray, Andrew J.
TI Chronic inorganic nitrate supplementation does not improve metabolic
   health and worsens disease progression in mice with diet-induced obesity
SO AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
LA English
DT Article
DE inorganic nitrate; metabolic dysfunction-associated steatotic liver
   disease; metabolism; mitochondria; obesity
ID REDUCES BLOOD-PRESSURE; WHITE ADIPOSE-TISSUE; FATTY LIVER-DISEASE;
   NITRIC-OXIDE; INSULIN-RESISTANCE; OXIDATIVE STRESS; RISK-FACTORS;
   MECHANISMS; GLUCOSE; HYPERTENSION
AB Inorganic nitrate (NO3-) has been proposed to be of therapeutic use as a dietary supplement in obesity and related conditions including the metabolic syndrome (MetS), type II diabetes, and metabolic dysfunction-associated steatotic liver disease (MASLD). Administration of NO3- to endothelial nitric oxide synthase-deficient mice reversed aspects of MetS; however, the impact of NO3- supplementation in diet-induced obesity is not well understood. Here we investigated the whole body metabolic phenotype and cardiac and hepatic metabolism in mice fed a high-fat, high-sucrose (HFHS) diet for up to 12 mo of age, supplemented with 1 mM NaNO3 (or NaCl) in their drinking water. HFHS feeding was associated with a progressive obesogenic and diabetogenic phenotype, which was not ameliorated by NO3-. Furthermore, HFHS-fed mice supplemented with NO3- showed elevated levels of cardiac fibrosis and accelerated progression of MASLD including development of hepatocellular carcinoma in comparison with NaCl-supplemented mice. NO3- did not enhance mitochondrial beta-oxidation capacity in any tissue assayed and did not suppress hepatic lipid accumulation, suggesting it does not prevent lipotoxicity. We conclude that NO3- is ineffective in preventing the metabolic consequences of an obesogenic diet and may instead be detrimental to metabolic health against the background of HFHS feeding. This is the first report of an unfavorable effect of long-term nitrate supplementation in the context of the metabolic challenges of overfeeding, warranting urgent further investigation into the mechanism of this interaction.
C1 [Sowton, Alice P.; Holzner, Lorenz M. W.; Baxter, Ruby; Krzyzanska, Dominika K.; O'Brien, Katie A.; Harrop, Matthew C.; Darwin, Paula M.; Thackray, Benjamin D.; Murray, Andrew J.] Univ Cambridge, Dept Physiol Dev & Neurosci, Cambridge, England.
   [Krause, Fynn N.; Mocciaro, Gabriele; Vacca, Michele; Griffin, Julian L.] Univ Cambridge, Dept Biochem, Cambridge, England.
   [Krause, Fynn N.; Mocciaro, Gabriele; Vacca, Michele; Griffin, Julian L.] Univ Cambridge, Syst Biol Ctr, Cambridge, England.
   [Minnion, Magdalena; Feelisch, Martin] Univ Southampton, Fac Med, Clin & Expt Sci, Southampton, England.
   [Vacca, Michele] Addenbrookes Hosp, Wellcome Trust MRC Inst Metab Sci Metab Res Labs, Cambridge, England.
   [Griffin, Julian L.] Univ Aberdeen, Rowett Inst, Aberdeen, Scotland.
C3 University of Cambridge; University of Cambridge; University of
   Cambridge; University of Southampton; University of Cambridge; Cambridge
   University Hospitals NHS Foundation Trust; Addenbrooke's Hospital;
   University of Aberdeen
RP Sowton, AP (corresponding author), Univ Cambridge, Dept Physiol Dev & Neurosci, Cambridge, England.
EM apb72@cam.ac.uk
RI Murray, Andrew/B-3130-2010; Vacca, Michele/B-4736-2013; Feelisch,
   Martin/C-3042-2008
OI Minnion, Magdalena/0000-0001-9239-5764; Feelisch,
   Martin/0000-0003-2320-1158; Griffin, Julian/0000-0003-1336-7744; Baxter,
   Ruby/0009-0009-0926-812X; Darwin, Paula/0000-0002-8408-4680; Sowton,
   Alice/0000-0002-3718-7783
FU Research Councils UK [(MC_UU_00014/5)]
FX We thank Sarah Royle, Matthew Rodgers, and Mithylan Ganeshwaran for help
   on the project and Benjamin Stockell for statistical advice. We also
   thank Hayley Forrest, Alison Robertson, and Ben Jaggs for support with
   animal work and Joe Lewis for support with the metabolic cage setup. We
   thank Kat Millen and Sarah Bray for use of thermocycler equipment
   throughout the study. We thank Hannah Mannering and the Disease Model
   Core (Wellcome-MRC Institute of Metabolic Sciences) for technical
   assistance in DEXA scans, James Warner and the Histopathology Core [MRC
   Metabolic Diseases Unit (MC_UU_00014/5)] for processing and embedding
   liver samples, and Peter Barker, Keith Burling, and the Cambridge
   Biochemical Assay Laboratory (Cambridge University Hospitals NHS
   Foundation Trust) for clinical chemistry analyses.
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NR 132
TC 0
Z9 0
U1 3
U2 3
PU AMER PHYSIOLOGICAL SOC
PI Rockville
PA 6120 Executive Blvd, Suite 600, Rockville, MD, UNITED STATES
SN 0193-1849
EI 1522-1555
J9 AM J PHYSIOL-ENDOC M
JI Am. J. Physiol.-Endocrinol. Metab.
PD JAN 9
PY 2025
VL 328
IS 1
BP E69
EP E91
DI 10.1152/ajpendo.00256.2024
PG 23
WC Endocrinology & Metabolism; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Physiology
GA 2NH3Z
UT WOS:001486714600002
PM 39653040
OA hybrid, Green Submitted
DA 2025-06-11
ER

PT J
AU Carr, AC
   Vlasiuk, E
   Zawari, M
   Lunt, H
AF Carr, Anitra C.
   Vlasiuk, Emma
   Zawari, Masuma
   Lunt, Helen
TI Understanding the additional impact of prediabetes and type 2 diabetes
   mellitus on vitamin C requirements in people living with obesity
SO NUTRITION RESEARCH
LA English
DT Article
DE Vitamin C; Obesity; Prediabetes; Diabetes; Type 2 diabetes; Metabolic
   dysregulation; Metabolic syndrome
ID OXIDATIVE STRESS
AB Obesity and diabetes are known to negatively affect vitamin C status. However, whether the presence of diabetes, in addition to obesity, contributes an additional impact on vitamin C status is currently uncertain. In a cohort of 152 adults living with obesity, we assessed metabolic and nutrient parameters in participants without diabetes ( n = 92), and with prediabetes ( n = 22) and type 2 diabetes mellitus (T2DM; n = 35). Vitamin C concentrations were measured in plasma and leukocytes using HPLC and vitamin C intakes were assessed using 24-hour dietary recall. Metabolic severity scores were derived using gender, ethnicity, height, weight, waist circumference, systolic blood pressure, fasting glucose, HDL, and triglyceride values. In people living with obesity, those with prediabetes and T2DM had increased metabolic dysregulation and decreased vitamin C status relative to those without diabetes ( P < .05). Vitamin C deficiency was observed in a high proportion (23%-32%) of participants with prediabetes and T2DM and >= 50% had hypovitaminosis C. However, there was no difference in vitamin C intake between those without diabetes and those with prediabetes or T2DM ( P > .05). There was a significant inverse correlation between plasma vitamin C status and metabolic severity score ( r = -0.290, P < .001). Linear regression indicated that for every 1-unit increase in metabolic severity score, there was a 6.5 mu mol/L decrease in vitamin C status. Thus, the enhanced metabolic dysregulation observed with prediabetes and T2DM is associated with an increased demand for vitamin C in people living with obesity. (c) 2024 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY license ( http://creativecommons.org/licenses/by/4.0/ )
C1 [Carr, Anitra C.; Vlasiuk, Emma; Zawari, Masuma] Univ Otago, Dept Pathol & Biomed Sci, Nutr Med Res Grp, POB 4345, Christchurch 8140, New Zealand.
   [Lunt, Helen] Hlth New Zealand Waitaha Canterbury, Diabet Outpatients, Christchurch, New Zealand.
   [Lunt, Helen] Univ Otago, Dept Med, Christchurch, New Zealand.
C3 University of Otago; University of Otago
RP Carr, AC (corresponding author), Univ Otago, Dept Pathol & Biomed Sci, Nutr Med Res Grp, POB 4345, Christchurch 8140, New Zealand.
EM anitra.carr@otago.ac.nz
FU Health Research Council of New Zealand [21/640]
FX This work was supported by the Health Research Council of New Zealand
   (grant number 21/640 to ACC) .r This work was supported by the Health
   Research Council of New Zealand (grant number 21/640 to ACC) .
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NR 44
TC 1
Z9 1
U1 3
U2 6
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0271-5317
EI 1879-0739
J9 NUTR RES
JI Nutr. Res.
PD OCT
PY 2024
VL 130
BP 1
EP 10
DI 10.1016/j.nutres.2024.08.001
EA SEP 2024
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA G9L1E
UT WOS:001319758500001
PM 39303359
OA hybrid
DA 2025-06-11
ER

PT J
AU Kityo, A
   Lee, SA
AF Kityo, Anthony
   Lee, Sang-Ah
TI Longitudinal changes in high sensitivity C-reactive protein associated
   with serum uric acid in the Korean Genome and Epidemiology Study
SO SCIENTIFIC REPORTS
LA English
DT Article
ID OXIDATIVE STRESS; CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; CANCER;
   INFLAMMATION
AB Cross-sectional studies support the role of serum uric acid (SUA) in inflammation, but evidence from cohort studies is scarce. Longitudinal associations between SUA and high-sensitivity C-reactive protein (hs-CRP) were examined in the general population. Data for participants from the Health Examinees-Gem cohort (n = 50,028; 40-69 years; 67% women) who were examined between 2004 and 2013 and followed up until 2016 were analyzed. SUA and hs-CRP were measured at baseline and during follow-up. SUA was evaluated as a continuous variable and was also divided into sex-specific quartiles. Mean hs-CRP levels at follow-up were evaluated using multivariable proportional odds regression, with non-linear smoothed baseline hs-CRP levels serving as a covariate. Selected pathological markers were also examined in relation to hs-CRP. Increased levels of SUA at baseline were related to increased levels of hs-CRP at follow-up [regression coefficient per mg/dL increase in baseline SUA (beta) = 0.08, 95% confidence interval (CI), 0.040-0.128]. A dose-response relationship was observed, (P for linear trend = 0.0015). The mean values of hs-CRP were highest among participants with the highest follow-up but lowest baseline SUA levels. Elevated hs-CRP levels at follow up (> 3 mg/L) were positively related to fasting blood glucose levels, triglycerides levels, liver enzymes, and blood pressure, but negatively related to high density lipoprotein cholesterol levels per unit increase in baseline hs-CRP. High SUA levels were associated with high hs-CRP levels, suggesting a potential role of SUA in inflammation. However, additional research is needed to confirm these findings.
C1 [Kityo, Anthony; Lee, Sang-Ah] Kangwon Natl Univ, Sch Med, Dept Prevent Med, Gangwon 24341, South Korea.
   [Lee, Sang-Ah] Kangwon Natl Univ, Interdisciplinary Grad Program Med Bigdata Converg, Gangwon 24341, South Korea.
C3 Kangwon National University; Kangwon National University
RP Lee, SA (corresponding author), Kangwon Natl Univ, Sch Med, Dept Prevent Med, Gangwon 24341, South Korea.; Lee, SA (corresponding author), Kangwon Natl Univ, Interdisciplinary Grad Program Med Bigdata Converg, Gangwon 24341, South Korea.
EM sangahlee@kangwon.ac.kr
RI Kityo, Anthony/GSD-9119-2022
FU Regional Innovation Strategy (RIS) through the National Research
   Foundation of Korea (NRF) - Ministry of Education (MOE) [2022RIS-005]
FX This research was supported by Regional Innovation Strategy (RIS)
   through the National Research Foundation of Korea (NRF) funded by the
   Ministry of Education (MOE) (2022RIS-005).
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NR 33
TC 4
Z9 4
U1 0
U2 0
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD JAN 3
PY 2024
VL 14
IS 1
AR 374
DI 10.1038/s41598-023-50951-2
PG 10
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA FL6P2
UT WOS:001145989400078
PM 38172510
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Romejko, K
   Rymarz, A
   Szamotulska, K
   Bartoszewicz, Z
   Rozmyslowicz, T
   Niemczyk, S
AF Romejko, Katarzyna
   Rymarz, Aleksandra
   Szamotulska, Katarzyna
   Bartoszewicz, Zbigniew
   Rozmyslowicz, Tomasz
   Niemczyk, Stanislaw
TI Resistin Contribution to Cardiovascular Risk in Chronic Kidney Disease
   Male Patients
SO CELLS
LA English
DT Article
DE cardiovascular risk; chronic kidney disease; resistin; plasminogen
   activator inhibitor-1
ID PLASMINOGEN-ACTIVATOR INHIBITOR-1; SERUM RESISTIN; INSULIN-RESISTANCE;
   METABOLIC SYNDROME; MYOCARDIAL-INFARCTION; CIRCULATING RESISTIN;
   FIBRINOLYTIC SYSTEM; ENDOTHELIAL-CELLS; OXIDATIVE STRESS; PLASMA
AB Background: Resistin is a molecule that belongs to the Resistin-Like Molecules family (RELMs), the group of proteins taking part in inflammatory processes. Increased resistin concentrations are observed in cardiovascular complications. Resistin contributes to the onset of atherosclerosis and intensifies the atherosclerotic processes. The aim of this study was to investigate the relationship between resistin and cardiovascular (CV) risk in men with chronic kidney disease (CKD) not treated with dialysis. Materials and Methods: One hundred and forty-two men were included in the study: 99 men with eGFR lower than 60 mL/min/1.73 m(2) and 43 men with eGFR >= 60 mL/min/1.73 m(2). CV risk was assessed. Serum resistin, tumor necrosis factor-alpha (TNF-alpha) and plasminogen activator inhibitor-1 (PAI-1) were measured among other biochemical parameters. Results: We observed that resistin concentrations were significantly higher in patients with CKD compared to individuals with eGFR lower than 60 mL/min/1.73 m(2) (p = 0.003). In CKD, after estimating the general linear model (GLM), we found that resistin is associated with CV risk (p = 0.026) and PAI-1 serum concentrations (0.012). The relationship of PAI-1 with resistin depends on the level of CV risk in CKD (p = 0.048). Conclusions: Resistin concentrations rise with the increase of CV risk in CKD patients and thus resistin may contribute to the progression of cardiovascular risk in this group of patients. The relationship between resistin and CV risk is modified by PAI-1 concentrations.
C1 [Romejko, Katarzyna; Rymarz, Aleksandra; Niemczyk, Stanislaw] Mil Inst Med, Natl Res Inst, Dept Internal Dis Nephrol & Dialysis, PL-04141 Warsaw, Poland.
   [Szamotulska, Katarzyna] Inst Mother & Child Hlth, Dept Epidemiol & Biostat, PL-01211 Warsaw, Poland.
   [Bartoszewicz, Zbigniew] Med Univ Warsaw, Dept Internal Dis & Endocrinol, PL-02097 Warsaw, Poland.
   [Rozmyslowicz, Tomasz] Univ Penn, Perelman Sch Med, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA.
C3 Military Institute of Aviation Medicine; Medical University of Warsaw;
   University of Pennsylvania
RP Romejko, K (corresponding author), Mil Inst Med, Natl Res Inst, Dept Internal Dis Nephrol & Dialysis, PL-04141 Warsaw, Poland.
EM katarzyna.szamotulska@imid.med.pl; zbigniew.bartoszewicz@wum.edu.pl;
   rozmyslo@pennmedicine.upenn.edu
RI Szamotulska, Katarzyna/K-2303-2012; Romejko, Katarzyna/GYU-1212-2022;
   Rymarz, Aleksandra/AAZ-9097-2021
OI Romejko, Katarzyna/0000-0003-1447-2917; Rymarz,
   Aleksandra/0000-0002-1844-9872; Szamotulska,
   Katarzyna/0000-0003-1045-7584
FU Military Institute of Medicine, Warsaw, Poland [120/WIM/2018]
FX This research was funded by an Internal grant of the Military Institute
   of Medicine, Warsaw, Poland, grant number 120/WIM/2018.
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NR 69
TC 2
Z9 2
U1 1
U2 2
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2073-4409
J9 CELLS-BASEL
JI Cells
PD APR
PY 2023
VL 12
IS 7
AR 999
DI 10.3390/cells12070999
PG 13
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA D6HL9
UT WOS:000969720600001
PM 37048072
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Arbizu, S
   Mertens-Talcott, SU
   Talcott, S
   Noratto, GD
AF Arbizu, Shirley
   Mertens-Talcott, Susanne U. U.
   Talcott, Stephen
   Noratto, Giuliana D. D.
TI Dark Sweet Cherry (Prunus avium) Supplementation Reduced Blood
   Pressure and Pro-Inflammatory Interferon Gamma (IFNγ) in Obese Adults
   without Affecting Lipid Profile, Glucose Levels and Liver Enzymes
SO NUTRIENTS
LA English
DT Article
DE dark sweet cherries; obesity; inflammation; metabolic disorders;
   clinical study
ID C-REACTIVE PROTEIN; OXIDATIVE STRESS; CIRCULATING CONCENTRATIONS;
   CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; MARKERS; RISK; ANTHOCYANINS;
   ASSOCIATION; CONSUMPTION
AB Dark sweet cherries (DSC) are rich in fiber and polyphenols that decrease risk factors associated with obesity. This single-blind randomized placebo-controlled study investigated DSC effects on inflammation, cardiometabolic, and liver health biomarkers in obese adults. Participants (>18 years, body mass index (BMI) = 30-40 kg/m(2)) consumed 200 mL of DSC drink (juice supplemented with DSC powder) (n = 19) or a placebo drink (n = 21) twice/day for 30 days. Anthropometric and physiological biomarkers were monitored at baseline (D1), mid-point (D15), and endpoint (D30) visits. Blood inflammatory biomarkers were assessed at D1, D15, and D30, and blood lipids, glucose, and liver enzymes at D1 and D30. DSC consumption lowered systolic blood pressure (SBP) (p = 0.05) and decreased diastolic blood pressure (DBP) compared to placebo (p = 0.04). Stratification of participants by BMI revealed a greater (p = 0.008) SBP reduction in BMI > 35 participants. DSC lowered pro-inflammatory interferon-gamma (IFN gamma) (p = 0.001), which correlated with SBP changes. The interleukin (IL)-1RA and SBP changes were correlated in the placebo group, as well as triglycerides (TG) with DBP. The increased IL-10 levels in the placebo group suggested a compensatory mechanism to counteract elevated IFN gamma levels. No significant between-group differences were detected for blood lipids, glucose, and liver enzymes. In conclusion, DSC helped to decrease blood pressure levels and inflammation in obese adults.
C1 [Arbizu, Shirley; Mertens-Talcott, Susanne U. U.; Talcott, Stephen; Noratto, Giuliana D. D.] Texas A&M Univ, Dept Food Sci & Technol, College Stn, TX 77843 USA.
C3 Texas A&M University System; Texas A&M University College Station
RP Noratto, GD (corresponding author), Texas A&M Univ, Dept Food Sci & Technol, College Stn, TX 77843 USA.
EM g.norattostevens@ag.tamu.edu
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NR 66
TC 16
Z9 17
U1 0
U2 8
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD FEB
PY 2023
VL 15
IS 3
AR 681
DI 10.3390/nu15030681
PG 20
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 8U9ZF
UT WOS:000930300300001
PM 36771387
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Betson, JR
   Kirkcaldie, MTK
   Zosky, GR
   Ross, RM
AF Betson, Jason R.
   Kirkcaldie, Matthew T. K.
   Zosky, Graeme R.
   Ross, Renee M.
TI Transition to shift work: Sleep patterns, activity levels, and
   physiological health of early-career paramedics
SO SLEEP HEALTH
LA English
DT Article
DE Actigraph; Ambulance; Emergency medical technician (EMT); Fatigue
ID BODY-MASS INDEX; METABOLIC SYNDROME; PHYSICAL-ACTIVITY; QUALITY INDEX;
   OBESITY; NURSES
AB The physiological impact of transitioning from full-time study to work in occupations that involve high-stress environments and shift work may plausibly impact sleep patterns and quality. There are limited studies focusing on the transition to shift work in graduate paramedics. This study aimed to assess early metabolic markers of health, activity, and sleep quality during the first 5 months of rostered shift work in a cohort of 28 graduate paramedics. Participants were tested for 4-week blocks before starting shift work (baseline), and during their first and fifth month of shift work. In each block, sleep and activity levels were monitored 24 h/day (workdays and nonworking days) using a wrist-worn actigraph. During shift work, the number of sleep episodes increased by 16.7% (p = .02) and self-reporting of poor sleep quality increased by 35.4% (p = .05); however, overall sleep quantity and sleep efficiency did not differ. Sleep metrics recorded during nonwork days were not different to baseline with exception of reduced sleep duration recorded the night before returning to work (5.99 +/- 1.66 hours Month 1; 5.72 +/- 1.06 hours Month 5). Sedentary behavior increased by 4.8% across the study, attributable to a significant decline in light exercise (p = .05). No changes were recorded in vigorous physical activity, average steps recorded per day, fasting blood glucose levels, systolic and diastolic blood pressure, weight, or waist circumference. These results warrant further large-scale and longitudinal studies to gauge any physiological implications for ongoing paramedic health. (c) 2022 National Sleep Foundation. Published by Elsevier Inc. All rights reserved.
C1 [Betson, Jason R.; Kirkcaldie, Matthew T. K.; Zosky, Graeme R.; Ross, Renee M.] Univ Tasmania, Coll Hlth & Med, Hobart, Tas, Australia.
   [Betson, Jason R.] Australian Catholic Univ, Fac Hlth, Melbourne, Vic, Australia.
   [Betson, Jason R.] Ambulance Victoria, Melbourne, Australia.
   [Betson, Jason R.] Bldg 403,Daniel Mannix Bldg,8 14 Brunswick St, Fitzroy, Vic 3065, Australia.
C3 University of Tasmania; Australian Catholic University; Ambulance
   Victoria
RP Betson, JR (corresponding author), Bldg 403,Daniel Mannix Bldg,8 14 Brunswick St, Fitzroy, Vic 3065, Australia.
EM jason.betson@acu.edu.au
RI Ross, Renee/IVV-0322-2023; Zosky, Graeme/B-2048-2014; Kirkcaldie,
   Matthew/J-4418-2012; Betson, Jason/N-8520-2016
OI Zosky, Graeme/0000-0001-9039-0302; Kirkcaldie,
   Matthew/0000-0003-3285-0168; Ross (Dwyer), Renee M/0000-0001-8361-2712;
   Betson, Jason/0000-0002-9883-8586
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NR 40
TC 13
Z9 13
U1 2
U2 11
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2352-7218
EI 2352-7226
J9 SLEEP HEALTH
JI Sleep Health
PD OCT
PY 2022
VL 8
IS 5
BP 514
EP 520
DI 10.1016/j.sleh.2022.06.001
PG 7
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 6G3YQ
UT WOS:000884691500013
PM 35907709
DA 2025-06-11
ER

PT J
AU Nanavati, K
   Rutherfurd-Markwick, K
   Lee, SJ
   Bishop, NC
   Ali, A
AF Nanavati, K.
   Rutherfurd-Markwick, K.
   Lee, S. J.
   Bishop, N. C.
   Ali, A.
TI Effect of curcumin supplementation on exercise-induced muscle damage: a
   narrative review
SO EUROPEAN JOURNAL OF NUTRITION
LA English
DT Review
DE Curcumin; Pharmacokinetics; Inflammation; Muscle soreness; Oxidative
   stress; Antioxidant
ID ECCENTRIC EXERCISE; SKELETAL-MUSCLE; ANTIINFLAMMATORY DRUGS;
   INFLAMMATORY MEDIATORS; KAPPA-B; SORENESS; BIOAVAILABILITY; ROS;
   PHARMACOKINETICS; INTERLEUKIN-6
AB Curcumin, a natural polyphenol extracted from turmeric, is a potent antioxidant and anti-inflammatory agent. In the past few decades, curcumin's ability to impact chronic inflammatory conditions such as metabolic syndrome, arthritis, and cancer has been widely researched, along with growing interest in understanding its role in exercise-induced muscle damage (EIMD). EIMD impacts individuals differently depending on the type (resistance exercise, high-intensity interval training, and running), intensity, and duration of the exercise. Exercise disrupts the muscles' ultrastructure, raises inflammatory cytokine levels, and can cause swelling in the affected limb, a reduction in range of motion (ROM), and a reduction in muscular force-producing capacity. This review focuses on the metabolism, pharmacokinetics of various brands of curcumin supplements, and the effect of curcumin supplementation on EIMD regarding muscle soreness, activity of creatine kinase (CK), and production of inflammatory markers. Curcumin supplementation in the dose range of 90-5000 mg/day can decrease the subjective perception of muscle pain intensity, increase antioxidant capacity, and reduce CK activity, which reduces muscle damage when consumed close to exercise. Consumption of curcumin also improves muscle performance and has an anti-inflammatory effect, downregulating the production of pro-inflammatory cytokines, including TNF-alpha, IL-6, and IL-8. Curcumin may also improve oxidative capacity without hampering training adaptations in untrained and recreationally active individuals. The optimal curcumin dose to ameliorate EIMD is challenging to assess as its effect depends on the curcumin concentration in the supplement and its bioavailability.
C1 [Nanavati, K.; Ali, A.] Massey Univ, Sch Sport Exercise & Nutr, Auckland, New Zealand.
   [Rutherfurd-Markwick, K.] Massey Univ, Sch Hlth Sci, Auckland, New Zealand.
   [Lee, S. J.] Massey Univ, Sch Food & Adv Technol, Auckland, New Zealand.
   [Bishop, N. C.] Loughborough Univ, Sch Sport Exercise & Hlth Sci, Loughborough, Leics, England.
C3 Massey University; Massey University; Massey University; Loughborough
   University
RP Ali, A (corresponding author), Massey Univ, Sch Sport Exercise & Nutr, Auckland, New Zealand.
EM k.nanavati@massey.ac.nz; k.j.rutherfurd@massey.ac.nz;
   s.j.lee@massey.ac.nz; n.c.bishop@lboro.ac.uk; a.ali@massey.ac.nz
RI Lee, sung/E-8961-2011; Ali, Ajmol/C-2154-2009
OI Rutherfurd-Markwick, Kay/0000-0002-8815-3786; Nanavati,
   Krutika/0000-0001-8638-3185; Lee, Sung Je/0000-0003-0634-1984; Ali,
   Ajmol/0000-0002-6093-1435; Bishop, Nicolette/0000-0001-6221-3907
FU CAUL
FX Open Access funding enabled and organized by CAUL and its Member
   Institutions.
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NR 82
TC 25
Z9 25
U1 4
U2 20
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1436-6207
EI 1436-6215
J9 EUR J NUTR
JI Eur. J. Nutr.
PD DEC
PY 2022
VL 61
IS 8
BP 3835
EP 3855
DI 10.1007/s00394-022-02943-7
EA JUL 2022
PG 21
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 5N9IL
UT WOS:000824298600001
PM 35831667
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Azizian, H
   Khaksari, M
   Asadikaram, G
   Esmailidehaj, M
   Shahrokhi, N
AF Azizian, Hossein
   Khaksari, Mohammad
   Asadikaram, Gholamreza
   Esmailidehaj, Mansour
   Shahrokhi, Nader
TI Progesterone eliminates 17β-estradiol-Mediated cardioprotection against
   diabetic cardiovascular dysfunction in ovariectomized rats
SO BIOMEDICAL JOURNAL
LA English
DT Article
DE Type 2 diabetes; 17 beta-estradiol; Progesterone; Cardiovascular;
   Cytokine; Lipid profile
ID ESTROGEN-RECEPTOR GPER; OXIDATIVE STRESS; INSULIN SENSITIVITY; MODEL;
   ATHEROSCLEROSIS; INHIBITION; ESTRADIOL; GLUCOSE; SYSTEM; ALPHA
AB Background: Type2 Diabetes (T2D) remains one of the most important causes of cardiovascular diseases (CVD). Menopause leads to an increase in CVD and metabolic syndrome, which indicates the role of sex steroids as a protective factor. In the present study, we surveyed the effects of 17 beta-estradiol (E2) alone and in combination with progesterone (P4) on cardiovascular dysfunction in T2D.
   Methods: Female ovariectomized (OVX) diabetic rats were divided into eight groups: ShamControl, Diabetes (Dia), OVX + Dia, OVX + Dia + Vehicle, OVX + Dia + E2, OVX + Dia + P4, OVX + Dia + E2+P4, and OVX + Dia + E2+Vehicle. T2D was induced by a high-fat diet and streptozotocin. E2 and P4 were administrated every four days for four weeks. The heart cytokines and angiotensin II, lipid profile, insulin, water, and food intake and cardiovascular indices were measured.
   Results: Results showed that single treatment with E2 decreased fasting blood glucose, water, and food intake, atherogenic and cardiac risk indices, and blood pressure. Also, P4 led to a decrease in atherogenic and cardiac risk indices. TNF alpha and IL-6 levels were increased and IL-10 was decreased in the Dia group, while E2 alone was able to inhibit these changes. The combined use of E2 and P4 eliminated the beneficial effects of E2 on these indices. Although diabetes results in an increment of cholesterol, LDL and triglyceride, hormone therapy with E2 was associated with improved dyslipidemia.
   Conclusion: The use of E2 alone, and not the individual use of P4, and its combination with E2 improved cardiovascular function in OVX diabetic animals, possibly by reducing the amount of inflammatory cytokines and improving metabolic parameters.
C1 [Azizian, Hossein; Esmailidehaj, Mansour] Shahid Sadoughi Univ Med Sci, Neurobiomed Res Ctr, Sch Med, Yazd, Iran.
   [Azizian, Hossein; Shahrokhi, Nader] Kerman Univ Med Sci, Fac Med, Dept Physiol, Kerman, Iran.
   [Khaksari, Mohammad] Kerman Univ Med Sci, Endocrinol & Metab Res, 64V4 HR2, Kerman, Iran.
   [Khaksari, Mohammad] Kerman Univ Med Sci, Physiol Res Ctr, 64V4 HR2, Kerman, Iran.
   [Asadikaram, Gholamreza] Kerman Univ Med Sci, Dept Biochem, Kerman, Iran.
   [Asadikaram, Gholamreza] Kerman Univ Med Sci, Metab & Endocrinol Res Ctr, Kerman, Iran.
C3 Shahid Sadoughi University of Medical Sciences; Kerman University of
   Medical Sciences; Kerman University of Medical Sciences; Kerman
   University of Medical Sciences; Kerman University of Medical Sciences;
   Kerman University of Medical Sciences
RP Khaksari, M (corresponding author), Kerman Univ Med Sci, Endocrinol & Metab Res, 64V4 HR2, Kerman, Iran.; Khaksari, M (corresponding author), Kerman Univ Med Sci, Physiol Res Ctr, 64V4 HR2, Kerman, Iran.
EM mkhaksari@kmu.ac.ir
RI Haddad, Mohammad/AAB-9025-2019; Asadikaram, Gholamreza/AAG-4437-2021;
   Azizian, Hossein/AGM-5429-2022; Esmailidehaj, Mansour/AAQ-5643-2021
OI Khaksari, Mohammad/0000-0003-0770-4281; Asadikaram,
   Gholamreza/0000-0002-9100-0756
FU  [95/105]
FX This study was a part of the Ph.D. thesis of Hossein Azizian (Grant
   No.95/105) and we thank Mr. Y. Masoumi-Ardakani and Mr. P. Ghotbi for
   their cooperation in this study.
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NR 45
TC 8
Z9 9
U1 0
U2 5
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2319-4170
EI 2320-2890
J9 BIOMED J
JI Biomed. J.
PD AUG
PY 2021
VL 44
IS 4
BP 461
EP 470
DI 10.1016/j.bj.2020.03.002
EA OCT 2021
PG 10
WC Biochemistry & Molecular Biology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Research & Experimental Medicine
GA WG7BY
UT WOS:000707149500004
PM 34507919
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Mohr, AE
   Reiss, RA
   Beaudet, M
   Sena, J
   Naik, JS
   Walker, BR
   Sweazea, KL
AF Mohr, Alex E.
   Reiss, Rebecca A.
   Beaudet, Monique
   Sena, Johnny
   Naik, Jay S.
   Walker, Benjimen R.
   Sweazea, Karen L.
TI Short-term high fat diet alters genes associated with metabolic and
   vascular dysfunction during adolescence in rats: a pilot study
SO PEERJ
LA English
DT Article
DE High fat diet; Aorta; Cardiovascular; Gene; RNA; Metabolic syndrome
ID HEAT-SHOCK-PROTEIN; CIRCADIAN CLOCK; THERAPEUTIC TARGET;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; ADIPOSE-TISSUE; RNA-SEQ;
   EXPRESSION; OBESITY; VASOCONSTRICTION
AB Background: Diet-induced metabolic dysfunction precedes multiple disease states including diabetes, heart disease, and vascular dysfunction. The critical role of the vasculature in disease progression is established, yet the details of how gene expression changes in early cardiovascular disease remain an enigma. The objective of the current pilot project was to evaluate whether a quantitative assessment of gene expression within the aorta of six-week old healthy male Sprague-Dawley rats compared to those exhibiting symptoms of metabolic dysfunction could reveal potential mediators of vascular dysfunction.
   Methods: RNA was extracted from the aorta of eight rats from a larger experiment; four animals fed a high-fat diet (HFD) known to induce symptoms of metabolic dysfunction (hypertension, increased adiposity, fasting hyperglycemia) and four age-matched healthy animals fed a standard chow diet (CHOW). The bioinformatic workflow included Gene Ontology (GO) biological process enrichment and network analyses.
   Results: The resulting network contained genes relevant to physiological processes including fat and protein metabolism, oxygen transport, hormone regulation, vascular regulation, thermoregulation, and circadian rhythm. The majority of differentially regulated genes were downregulated, including several associated with circadian clock function. In contrast, leptin and 3-hydroxy-3-methylglutaryl-CoA synthase 2 (Hmgcs2) were notably upregulated. Leptin is involved in several major energy balance signaling pathways and Hmgcs2 is a mitochondrial enzyme that catalyzes the first reaction of ketogenesis.
   Conclusion: Together, these data describe changes in gene expression within the aortic wall of HFD rats with early metabolic dysfunction and highlight potential pathways and signaling intermediates that may impact the development of early vascular dysfunction.
C1 [Mohr, Alex E.] Arizona State Univ, Coll Hlth Solut, Phoenix, AZ USA.
   [Reiss, Rebecca A.; Beaudet, Monique] New Mexico Inst Min & Technol, Biol Dept, Socorro, NM 87801 USA.
   [Sena, Johnny] Natl Ctr Genome Resources, Santa Fe, NM USA.
   [Naik, Jay S.; Walker, Benjimen R.] Univ New Mexico, Dept Cell Biol & Physiol, Albuquerque, NM 87131 USA.
   [Sweazea, Karen L.] Arizona State Univ, Coll Hlth Solut, Tempe, AZ 85281 USA.
   [Sweazea, Karen L.] Arizona State Univ, Sch Life Sci, Tempe, AZ 85281 USA.
C3 Arizona State University; Arizona State University-Downtown Phoenix; New
   Mexico Institute of Mining Technology; National Center for Genome
   Resources (NCGR); University of New Mexico; Arizona State University;
   Arizona State University-Tempe; Arizona State University; Arizona State
   University-Tempe
RP Sweazea, KL (corresponding author), Arizona State Univ, Coll Hlth Solut, Tempe, AZ 85281 USA.; Sweazea, KL (corresponding author), Arizona State Univ, Sch Life Sci, Tempe, AZ 85281 USA.
EM Karen.Sweazea@asu.edu
RI Naik, Jay/AHD-1227-2022; Sweazea, Karen/AAT-4151-2020
OI Reiss, Rebecca/0000-0002-9884-0440; Sena, Johnny/0000-0003-1846-8739;
   Mohr, Alex/0000-0001-5401-3702; Naik, Vijay/0000-0002-5725-4664;
   Sweazea, Karen/0000-0003-0345-4086
FU National Center for Research Resources [5P20RR016480-12]; National
   Institute of General Medical Sciences [8 P20 GM103451-12]; National
   Institutes of Health
FX This project was supported by grants from the National Center for
   Research Resources (5P20RR016480-12) and the National Institute of
   General Medical Sciences (8 P20 GM103451-12) from the National
   Institutes of Health. There was no additional external funding received
   for this study. The funders had no role in study design, data collection
   and analysis, decision to publish, or preparation of the manuscript.
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NR 91
TC 3
Z9 3
U1 0
U2 2
PU PEERJ INC
PI LONDON
PA 341-345 OLD ST, THIRD FLR, LONDON, EC1V 9LL, ENGLAND
SN 2167-8359
J9 PEERJ
JI PeerJ
PD JUL 9
PY 2021
VL 9
AR e11714
DI 10.7717/peerj.11714
PG 25
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA TG7LV
UT WOS:000671582500002
PM 34285833
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Souza, LL
   de Moura, EG
   Lisboa, PC
AF Souza, Luana Lopes
   de Moura, Egberto Gaspar
   Lisboa, Patricia Cristina
TI Does early weaning shape future endocrine and metabolic disorders?
   Lessons from animal models
SO JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE
LA English
DT Review
DE Breastfeeding; milk; adiposity; hormone; metabolic programming
ID MATERNAL PROLACTIN INHIBITION; BODY-MASS INDEX; HIGHER NEUROPEPTIDE-Y;
   DEVELOPMENTAL ORIGINS; LACTATION PROGRAMS; LEPTIN RESISTANCE; OXIDATIVE
   STRESS; GENE-EXPRESSION; NOVELTY-SEEKING; BLOOD-PRESSURE
AB Obesity and its complications occur at alarming rates worldwide. Epidemiological data have associated perinatal conditions, such as malnutrition, with the development of some disorders, such as obesity, dyslipidemia, diabetes, and cardiovascular diseases, in childhood and adulthood. Exclusive breastfeeding has been associated with protection against long-term chronic diseases. However, in humans, the interruption of breastfeeding before the recommended period of 6 months is a common practice and can increase the risk of several metabolic disturbances. Nutritional and environmental changes within a critical window of development, such as pregnancy and breastfeeding, can induce permanent changes in metabolism through epigenetic mechanisms, leading to diseases later in life via a phenomenon known as programming or developmental plasticity. However, little is known regarding the underlying mechanisms by which precocious weaning can result in adipose tissue dysfunction and endocrine profile alterations. Here, the authors give a comprehensive report of the different animal models of early weaning and programming that can result in the development of metabolic syndrome. In rats, for example, pharmacological and nonpharmacological early weaning models are associated with the development of overweight and visceral fat accumulation, leptin and insulin resistance, and neuroendocrine and hepatic changes in adult progeny. Sex-related differences seem to influence this phenotype. Therefore, precocious weaning seems to be obesogenic for offspring. A better understanding of this condition seems essential to reducing the risk for diseases. Additionally, this knowledge can generate new insights into therapeutic strategies for obesity management, improving health outcomes.
C1 [Souza, Luana Lopes; de Moura, Egberto Gaspar; Lisboa, Patricia Cristina] Univ Estado Rio De Janeiro, Lab Endocrine Physiol, Dept Physiol Sci, Roberto Alcantara Gomes Biol Inst, Rio De Janeiro, RJ, Brazil.
C3 Universidade do Estado do Rio de Janeiro
RP Lisboa, PC (corresponding author), Univ Estado Rio de Janeiro, Inst Biol Roberto Alcantara Gomes, Lab Fisiol Endocrina, Dept Ciencias Fisiol, Ave 28 Setembro,87 Fundos,PAPC 5 Andar, BR-20551030 Rio De Janeiro, RJ, Brazil.
EM pclisboa@uerj.br
RI Moura, Egberto/H-1270-2012; Souza, Luana/AFO-3592-2022; Moura,
   Egberto/ABA-6188-2021; Lisboa, Patricia/H-8336-2015
OI Lisboa, Patricia/0000-0002-2477-4364
FU Conselho Nacional de Desenvolvimento Cientifico e Tecnol'ogico (CNPq);
   Fundacao Carlos Chagas Filho de Amparo a Pesquisa do Estado do Rio de
   Janeiro (FAPERJ); Coordenacao de Aperfeicoamento de Pessoal de Nivel
   Superior (CAPES) [001]
FX LLS, EGM, and PCL are researchers from the State University of Rio de
   Janeiro, which have research projects supported by Conselho Nacional de
   Desenvolvimento Cientifico e Tecnologico (CNPq), Fundacao Carlos Chagas
   Filho de Amparo a Pesquisa do Estado do Rio de Janeiro (FAPERJ), and
   Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES,
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NR 121
TC 12
Z9 13
U1 0
U2 14
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 2040-1744
EI 2040-1752
J9 J DEV ORIG HLTH DIS
JI J. Dev. Orig. Health Dis.
PD OCT
PY 2020
VL 11
IS 5
BP 441
EP 451
AR PII S2040174420000410
DI 10.1017/S2040174420000410
PG 11
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA NO3ET
UT WOS:000569368100002
PM 32487270
DA 2025-06-11
ER

PT J
AU Adeyanju, OA
   Falodun, TO
   Michael, OS
   Soetan, OA
   Oyewole, AL
   Agbana, RD
AF Adeyanju, Oluwaseun A.
   Falodun, Timothy O.
   Michael, Olugbenga S.
   Soetan, Olaniyi A.
   Oyewole, Aboyeji L.
   Agbana, Richard D.
TI Spironolactone reversed hepato-ovarian triglyceride accumulation caused
   by letrozole-induced polycystic ovarian syndrome: tissue uric acid-a
   familiar foe
SO NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
LA English
DT Article
DE Triglyceride accumulation; PCOS; Spironolactone; NAFLD; Uric acid
ID FATTY LIVER-DISEASE; INSULIN-RESISTANCE; OXIDATIVE STRESS; ENDOTHELIAL
   DYSFUNCTION; METABOLIC SYNDROME; XANTHINE-OXIDASE; NONOBESE WOMEN;
   FEMALE MICE; IN-UTERO; RISK
AB Polycystic ovarian syndrome (PCOS) is a complex endocrine disease among women of reproductive age and is one of the main causes of infertility. Non-alcoholic fatty liver disease (NAFLD), the most prominent chronic liver disease in adults, is characterized by excess hepatic triglyceride (TG) accumulation. PCOS women have increased risk of NAFLD and uric acid has been documented to have a positive correlation with subclinical tissue damage and might be the link in the cystic. Spironolactone (SPL) is a mineralocorticoid receptor (MR) blocker that has been in wide clinical use for some decades. In this research, we investigated the effects of SPL on ovarian and hepatic tissue damage in experimental PCOS rats induced by letrozole (LET). A total of eighteen adult female Wistar rats were used for this study and the animals divided into 3 groups are treated with vehicle, LET (1 mg/kg), and LET+SPL (SPL; 0.25 mg/kg), p.o. once daily respectively for 21 uninterrupted days. Results showed that LET treatment induced features of PCOS characterized by increased plasma testosterone (T) and luteinizing hormone (LH) together with increased body weight. Abnormal ovarian and hepatic histomorphological changes were also observed with elevated uric acid (UA) and TG accumulation in both tissues respectively. Treatment with SPL however attenuated the elevated testosterone in the LET-induced PCOS model accompanied with a reversal in the observed ovarian and hepatic UA, TG accumulation, and altered histomorphological changes. Taken together, spironolactone reversed the PCOS-induced ovarian and hepatic tissue damage by suppressing tissue UA and TG accumulation.
C1 [Adeyanju, Oluwaseun A.; Falodun, Timothy O.] Afe Babalola Univ, Coll Med & Hlth Sci, Dept Physiol, Cardiometab Res Unit, PMB 5454, Ado Ekiti 360101, Nigeria.
   [Adeyanju, Oluwaseun A.; Michael, Olugbenga S.; Soetan, Olaniyi A.] Univ Ilorin, HOPE Cardiometab Res Team, Ilorin, Nigeria.
   [Adeyanju, Oluwaseun A.; Michael, Olugbenga S.; Soetan, Olaniyi A.] Univ Ilorin, Dept Physiol, Ilorin, Nigeria.
   [Adeyanju, Oluwaseun A.; Michael, Olugbenga S.; Soetan, Olaniyi A.; Oyewole, Aboyeji L.] Biosci Res Hub, Ilorin, Kwara State, Nigeria.
   [Michael, Olugbenga S.] Bowen Univ, Coll Hlth Sci, Dept Physiol, Cardiometab Res Unit, Iwo, Nigeria.
   [Oyewole, Aboyeji L.] Univ Ilorin, Coll Med & Hlth Sci, Dept Physiol, Ilorin, Nigeria.
   [Agbana, Richard D.] Afe Babalola Univ, Coll Med & Hlth Sci, Dept Community Med, Ado Ekiti, Nigeria.
C3 University of Ilorin; University of Ilorin; University of Ilorin
RP Adeyanju, OA (corresponding author), Afe Babalola Univ, Coll Med & Hlth Sci, Dept Physiol, Cardiometab Res Unit, PMB 5454, Ado Ekiti 360101, Nigeria.; Adeyanju, OA (corresponding author), Univ Ilorin, HOPE Cardiometab Res Team, Ilorin, Nigeria.; Adeyanju, OA (corresponding author), Univ Ilorin, Dept Physiol, Ilorin, Nigeria.; Adeyanju, OA (corresponding author), Biosci Res Hub, Ilorin, Kwara State, Nigeria.
EM adeyanjuoa@abuad.edu.ng
RI Michael, Olugbenga/ABH-4359-2020; Adeyanju, Oluwaseun/HJP-1273-2023;
   Oyewole, Aboyeji/NDT-4226-2025
OI Agbana, Richard Dele/0000-0002-7651-5145; Adeyanju,
   Oluwaseun/0000-0003-4824-6766; Michael, Olugbenga/0000-0001-8119-4043
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NR 76
TC 13
Z9 15
U1 0
U2 12
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0028-1298
EI 1432-1912
J9 N-S ARCH PHARMACOL
JI Naunyn-Schmiedebergs Arch. Pharmacol.
PD JUN
PY 2020
VL 393
IS 6
BP 1055
EP 1066
DI 10.1007/s00210-020-01809-1
PG 12
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA LN6YX
UT WOS:000533081300012
PM 31925474
DA 2025-06-11
ER

PT J
AU Sadie-Van Gijsen, H
AF Sadie-Van Gijsen, Hanel
TI Adipocyte biology: It is time to upgrade to a new model
SO JOURNAL OF CELLULAR PHYSIOLOGY
LA English
DT Review
DE adipocyte cell models; adipose depots; adipose-derived stromal/stem
   cells; obesity
ID MESENCHYMAL STEM-CELLS; HUMAN ADIPOSE-TISSUE; STROMAL-VASCULAR FRACTION;
   ENHANCES ADIPOGENIC DIFFERENTIATION; DEDIFFERENTIATED FAT-CELLS;
   NECROSIS-FACTOR-ALPHA; DIET-INDUCED OBESITY; INFLAMMATION-RELATED
   ADIPOKINES; ENDOPLASMIC-RETICULUM STRESS; METABOLIC SYNDROME
AB Globally, the obesity pandemic is profoundly affecting quality of life and economic productivity, but efforts to address this, especially on a pharmacological level, have generally proven unsuccessful to date, serving as a stark demonstration that our understanding of adipocyte biology and pathophysiology is incomplete. To deliver better insight into adipocyte function and obesity, we need improved adipocyte models with a high degree of fidelity in representing the in vivo state and with a diverse range of experimental applications. Adipocyte cell lines, especially 3T3-L1 cells, have been used extensively over many years, but these are limited in terms of relevance and versatility. In this review, I propose that primary adipose-derived stromal/stem cells (ASCs) present a superior model with which to study adipocyte biology ex vivo. In particular, ASCs afford us the opportunity to study adipocytes from different, functionally distinct, adipose depots and to investigate, by means of in vivo/ex vivo studies, the effects of many different physiological and pathophysiological factors, such as age, body weight, hormonal status, diet and nutraceuticals, as well as disease and pharmacological treatments, on the biology of adipocytes and their precursors. This study will give an overview of the characteristics of ASCs and published studies utilizing ASCs, to highlight the areas where our knowledge is lacking. More comprehensive studies in primary ASCs will contribute to an improved understanding of adipose tissue, in healthy and dysfunctional states, which will enhance our efforts to more successfully manage and treat obesity.
C1 [Sadie-Van Gijsen, Hanel] Stellenbosch Univ, Div Endocrinol, Dept Med, Fac Med & Hlth Sci, Parow, South Africa.
   [Sadie-Van Gijsen, Hanel] Stellenbosch Univ, Div Med Physiol, Dept Biomed Sci, Fac Med & Hlth Sci, Fisan Bldg,Tygerberg Campus,Francie Van Zijl Dr, ZA-7505 Parow, South Africa.
RP Sadie-Van Gijsen, H (corresponding author), Stellenbosch Univ, Div Med Physiol, Dept Biomed Sci, Fac Med & Hlth Sci, Fisan Bldg,Tygerberg Campus,Francie Van Zijl Dr, ZA-7505 Parow, South Africa.
EM hsadie@sun.ac.za
RI Sadie-Van Gijsen, Hanél/AFZ-9395-2022
OI Sadie-Van Gijsen, Hanel/0000-0002-1745-563X
FU South African National Research Foundation; South African Rooibos
   Council
FX South African National Research Foundation; South African Rooibos
   Council
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NR 317
TC 22
Z9 22
U1 0
U2 90
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0021-9541
EI 1097-4652
J9 J CELL PHYSIOL
JI J. Cell. Physiol.
PD MAR
PY 2019
VL 234
IS 3
BP 2399
EP 2425
DI 10.1002/jcp.27266
PG 27
WC Cell Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Physiology
GA HC2FU
UT WOS:000451618500040
PM 30192004
DA 2025-06-11
ER

PT J
AU Wang, AY
   Ma, HP
   Kao, WF
   Tsai, SH
   Chang, CK
AF Wang, An-Yi
   Ma, Hon-Ping
   Kao, Wei-Fong
   Tsai, Shin-Han
   Chang, Cheng-Kuei
TI Red blood cell distribution width is associated with mortality in
   elderly patients with sepsis
SO AMERICAN JOURNAL OF EMERGENCY MEDICINE
LA English
DT Article
DE Aged; Red blood cell distribution width; Sepsis
ID INDEPENDENT PREDICTOR; PROGNOSTIC MARKER; LARGE COHORT; ANEMIA; RISK;
   STRESS; DEATH
AB Introduction: RDW is a prognostic biomarker and associated with mortality in cardiovascular disease, stroke and metabolic syndrome. For elderly patients, malnutrition and multiple comorbidities exist, which could affect the discrimination ability of RDW in sepsis. The main purpose of our study was to evaluate the prognostic value of RDW in sepsis among elderly patients.
   Methods: This was a retrospective cohort study conducted in emergency department intensive care units (ED-ICU) between April 2015 and November 2015. Elderly patients (>= 65 years old) who were admitted to the ED-ICU with a diagnosis of severe sepsis and/or septic shock were included. The demographic data, biochemistry data. qSOFA, and APACHE II score were compared between survivors and nonsurvivors.
   Results: A total of 117 patients was included with mean age 81.5 +/- 83 years old. The mean APACHE II score was 21.9 +/- 7.1. In the multivariate Cox proportional hazards model, RDW level was an independent variable for mortality (hazard ratio: 1.18 [1.03-135] for each 1% increase in RDW, p = 0.019), after adjusting for CCI, any diagnosed malignancy, and eGFR. The AUC of RDW in predicting mortality was 0.63 (95% confidence interval [CI]: 0.52-0.74, p = 0.025). In subgroup analysis, for qSOFA <2, nonsurvivors had higher RDW levels than survivors (17.0 +/- 3.3 vs. 15.3 +/- 1.4%, p = 0.044).
   Conclusions: In our study, RDW was an independent predictor of in-hospital mortality in elderly patients with sepsis. For qSOFA scores <2, higher RDW levels were associated with poor prognosis. RDW could be a potential parameter used alongside the clinical prediction rules. (C) 2017 Elsevier Inc. All rights reserved.
C1 [Wang, An-Yi; Ma, Hon-Ping; Kao, Wei-Fong] Taipei Med Univ, Sch Med, Dept Emergency Med, Coll Med, Taipei, Taiwan.
   [Wang, An-Yi; Ma, Hon-Ping; Tsai, Shin-Han; Chang, Cheng-Kuei] Taipei Med Univ, Grad Inst Injury Prevent & Control, Coll Publ Hlth, Taipei, Taiwan.
   [Wang, An-Yi; Ma, Hon-Ping; Kao, Wei-Fong] Taipei Med Univ Hosp, Dept Emergency Med, Taipei, Taiwan.
   [Tsai, Shin-Han] Shuang Ho Hosp, Dept Emergency Med, New Taipei, Taiwan.
   [Chang, Cheng-Kuei] Shuang Ho Hosp, Dept Neurosurg, New Taipei, Taiwan.
C3 Taipei Medical University; Taipei Medical University; Taipei Medical
   University; Taipei Medical University Hospital; Taipei Medical
   University; Shuang Ho Hospital; Taipei Medical University; Shuang Ho
   Hospital
RP Chang, CK (corresponding author), Taipei Med Univ, Grad Inst Injury Prevent & Control, Coll Publ Hlth, Taipei, Taiwan.
EM 11064@s.tmu.edu.tw
RI Lu, Chi-Cheng/N-7770-2013
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NR 40
TC 60
Z9 63
U1 0
U2 9
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0735-6757
EI 1532-8171
J9 AM J EMERG MED
JI Am. J. Emerg. Med.
PD JUN
PY 2018
VL 36
IS 6
BP 949
EP 953
DI 10.1016/j.ajem.2017.10.056
PG 5
WC Emergency Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Emergency Medicine
GA GI6GV
UT WOS:000434468500008
PM 29133071
DA 2025-06-11
ER

PT J
AU Malakul, W
   Pengnet, S
   Kumchoom, C
   Tunsophon, S
AF Malakul, Wachirawadee
   Pengnet, Sirinat
   Kumchoom, Chanon
   Tunsophon, Sakara
TI Naringin ameliorates endothelial dysfunction in fructose-fed rats
SO EXPERIMENTAL AND THERAPEUTIC MEDICINE
LA English
DT Article
DE naringin; fructose-fed rats; endothelial dysfunction; nitric oxide;
   nitrotyrosine
ID INDUCED OXIDATIVE STRESS; NITRIC-OXIDE; INSULIN-RESISTANCE; METABOLIC
   SYNDROME; HYPERTENSION; DISEASE; HYPERLIPIDEMIA; MECHANISMS; HESPERIDIN;
   ARTERIES
AB High fructose consumption is associated with metabolic disorders including hyperglycemia and dyslipidemia, in addition to endothelial dysfunction. Naringin, a flavonoid present in citrus fruit, has been reported to exhibit lipid lowering, antioxidant, and cardiovascular protective properties. Therefore, the present study investigated the effect of naringin on fructose-induced endothelial dysfunction in rats and its underlying mechanisms. Male Sprague-Dawley rats were given 10% fructose in drinking water for 12 weeks, whereas control rats were fed drinking water alone. Naringin (100 mg/kg) was orally administered to fructose fed rats during the last 4 weeks of the study. Following 12 weeks, blood samples were collected for measurement of blood glucose, serum lipid profile and total nitrate/nitrite (NOx). Vascular function was assessed by isometric tension recording. Aortic expression of endothelial nitric oxide synthase (eNOS), phosphorylated eNOS (p-eNOS), and nitrotyrosine were evaluated by western blot analysis. Fructose feeding induced increased levels of blood glucose, total cholesterol, triglyceride, and low density lipoprotein. In rat aortae, fructose reduced acethycholine-induced vasorelaxation, without affecting sodium nitroprusside-induced vasorelaxation. Treatment of fructose-fed rats with naringin restored fructose-induced metabolic alterations and endothelial dysfunction. Fructose-fed rats also exhibited decreased serum NOx level, reduced eNOS and p-eNOS protein expression, and enhanced nitrotyrosine expression in aortae. These alterations were improved by naringin treatment. The results of the present study suggested that naringin treatment preservesendothelium-dependent relaxation in aortae from fructose fed rats. This effect is primarily mediated through an enhanced NO bioavailability via increased eNOS activity and decreased NO inactivated to peroxynitrite in aortae.
C1 [Malakul, Wachirawadee; Kumchoom, Chanon; Tunsophon, Sakara] Naresuan Univ, Fac Med Sci, Dept Physiol, Phitsanulok 65000, Thailand.
   [Pengnet, Sirinat] Univ Phayao, Sch Med Sci, Div Physiol, Phayao 56000, Thailand.
C3 Naresuan University; University of Phayao
RP Malakul, W (corresponding author), Naresuan Univ, Fac Med Sci, Dept Physiol, 99 Moo 9 Phitsanulok Nakhonsawan Rd, Muang Phitsanulok 65000, Thailand.
EM wachirawadeem@hotmail.com
RI Malakul, Wachirawadee/GQQ-6452-2022
OI Tunsophon, Sakara/0000-0002-5614-1908
FU National Research Council of Thailand
FX This study was supported by grants from the National Research Council of
   Thailand. The authors would like to thank Mr. Roy Morien of the naresuan
   university language centre for his editing assistance and advice on
   english expression in this document. The authors declare no conflict of
   interest.
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NR 44
TC 35
Z9 36
U1 0
U2 18
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1792-0981
EI 1792-1015
J9 EXP THER MED
JI Exp. Ther. Med.
PD MAR
PY 2018
VL 15
IS 3
BP 3140
EP 3146
DI 10.3892/etm.2018.5759
PG 7
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA FZ6XI
UT WOS:000427743500137
PM 29456717
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Prickett, TCR
   Darlow, BA
   Troughton, RW
   Cameron, VA
   Elliott, JM
   Martin, J
   Horwood, LJ
   Espiner, EA
AF Prickett, Timothy C. R.
   Darlow, Brian A.
   Troughton, Richard W.
   Cameron, Vicky A.
   Elliott, John M.
   Martin, Julia
   Horwood, L. John
   Espiner, Eric A.
TI New Insights into Cardiac and Vascular Natriuretic Peptides: Findings
   from Young Adults Born with Very Low Birth Weight
SO CLINICAL CHEMISTRY
LA English
DT Article
ID C-TYPE; CARDIOVASCULAR-DISEASE; BLOOD-PRESSURE; ENDOTHELIAL FUNCTION;
   METABOLIC SYNDROME; PRETERM BIRTH; NT-PROBNP; RISK; PLASMA;
   ATHEROSCLEROSIS
AB BACKGROUND: In community studies, plasma B-type natriuretic peptide (BNP) is positively associated with cardiovascular disorders. Those born with very low birth weight (VLBW) have increased risk of metabolic and vascular disorders in later life, but plasma concentrations of natriuretic peptides have not been studied. The objectives here were to evaluate BNP and C-type natriuretic peptide (CNP)-a putative marker of vascular risk-in young adults born with VLBW.
   METHODS: In all, 220 VLBW cases and 97 matched controls were studied 28 years after birth during a 2-day period at 1 research center. Aminoterminal (NT) products (NTproBNP, NTproCNP) and a range of conventional vascular risk factors including echocardiographic indices were measured along with genetic polymorphisms known to increase plasma NTproBNP.
   RESULTS: VLBW individuals were smaller, had smaller hearts, reduced stroke volume and endothelial function, and higher systolic blood pressure and arterial elastance. Of the many humoral vascular and metabolic risk factors measured, including NTproBNP, only plasma NTproCNP (higher in VLBW individuals) differed significantly. Across all individuals, associations of NTproCNP with each of 7 conventional risk factors, as well as with arterial elastance, were positive, whereas associations of NTproBNP with risk were all inverse. In multivariate analysis, the genetic variant rs198358 was independently associated with NTproBNP.
   CONCLUSIONS: In young adults at increased risk of cardiovascular disease, higher NTproCNP likely reflects a compensatory vascular response to vascular stress, whereas the negative link with NTproBNP likely reflects beneficial genetic mutations. The ratio of NTproBNP to NTproCNP may provide a novel index of ideal cardiovascular health. (c) 2017 American Association for Clinical Chemistry
C1 [Prickett, Timothy C. R.; Troughton, Richard W.; Cameron, Vicky A.; Elliott, John M.; Espiner, Eric A.] Univ Otago, Dept Med, 2 Riccarton Ave,POB 4345, Christchurch 8140, New Zealand.
   [Darlow, Brian A.; Martin, Julia] Univ Otago, Dept Paediat, Christchurch, New Zealand.
   [Horwood, L. John] Univ Otago, Dept Psychol Med, Christchurch, New Zealand.
C3 University of Otago; University of Otago; University of Otago
RP Prickett, TCR (corresponding author), Univ Otago, Dept Med, 2 Riccarton Ave,POB 4345, Christchurch 8140, New Zealand.
EM tim.prickett@otago.ac.nz
RI Cameron, Vicky/L-4046-2019
OI Cameron, Vicky/0000-0003-3147-683X; Troughton,
   Richard/0000-0001-7484-4036
FU New Zealand Lottery Grants Board; Christchurch Heart Institute; New
   Zealand Health Research Council [12-129]; Child Health Research
   Foundation [CHRF 5040, CHRF 5041]
FX Cure Kids. T.C.R. Prickett, the New Zealand Lottery Grants Board, the
   Christchurch Heart Institute; B.A. Darlow, New Zealand Health Research
   Council (project grant 12-129), the Child Health Research Foundation
   (CHRF 5040 and CHRF 5041).
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NR 40
TC 15
Z9 15
U1 0
U2 3
PU AMER ASSOC CLINICAL CHEMISTRY
PI WASHINGTON
PA 2101 L STREET NW, SUITE 202, WASHINGTON, DC 20037-1526 USA
SN 0009-9147
EI 1530-8561
J9 CLIN CHEM
JI Clin. Chem.
PD FEB
PY 2018
VL 64
IS 2
BP 363
EP 373
DI 10.1373/clinchem.2017.280354
PG 11
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA FV2KT
UT WOS:000424396200020
PM 29097512
OA Bronze
DA 2025-06-11
ER

PT J
AU Du, F
   Liu, DS
   He, G
   Chen, DG
AF Du, Fei
   Liu, Daishun
   He, Gang
   Chen, Daigang
TI EFFECT OF SIMVASTATIN ON SERUM GAMMA-GLUTAMYLTRANSFERASE AND C-REACTIVE
   PROTEIN IN PATIENT WITH ACUTE EXACERBATION CHRONIC OBSTRUCTIVE PULMONARY
   DISEASE
SO ACTA MEDICA MEDITERRANEA
LA English
DT Article
DE simvastatin; chronic obstructive pulmonary disease; gamma-glutamyl
   transferase; C-reactive protein
ID STATIN USE; CARDIOVASCULAR-DISEASE; REDUCTASE INHIBITOR; METABOLIC
   SYNDROME; OXIDATIVE STRESS; LUNG-FUNCTION; COPD; RISK; THERAPY; DECLINE
AB Objective: Retrospective studies have shown that statins decrease the rate and severity of exacerbations, the rate of hospitalization, and mortality in chronic obstructive pulmonary disease(COPD). To explore the effect of simvastatin on serum gamma-glutamyl transferase (GGT) and C-reactive protein (CRP) on patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).
   Methods: 60 cases with AECOPD were randomly divided into the treatment group and control group. In addition to routine comprehensive treatment in both groups, additional 20mg Simvastatin was given to the treatment group by per os, once per night for two weeks. We observed the change of GGT activity and serum CRP concentration before and after treated in the two groups. Meanwhile, the pulmonary function measurements were performed.
   Results: There were no significant differences in the pulmonary function: forced expiratory volume in one second(FEV1), forced vital capacity(FVC), forced vital capacity rate of one second(FEV1/FVC), peak expiratory flow(PEF), residual volume(RV) and residual volume to total lung capacity(RV/TLC) and the serum GGT and CRP levels between the two groups before treatment. The control group showed no significant changes in any parameters before and after two-week treatment. The pulmonary function in the treatment group after two week treatment significantly improved compared with those before treatment and the control group, but the serum GGT activity and CRP levels significantly decreased.
   Conclusions: Simvastatin may reduce the decline in pulmonary function and decrease the levels of serum GGT and CRP of patients with AECOPD. Improvement in pulmonary function may be related to it.
C1 [Du, Fei; Liu, Daishun; He, Gang; Chen, Daigang] First Peoples Hosp Zun Yi, Dept Resp Med, Zunyi Gui Zhou 563000, Zhejiang, Peoples R China.
RP Du, F (corresponding author), First Peoples Hosp Zun Yi, Dept Resp Med, Zunyi Gui Zhou 563000, Zhejiang, Peoples R China.
EM fei632@163.com
FU Technology Division of ZunYi [[2013]02]
FX Technology Division of ZunYi NO. [2013]02
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NR 36
TC 2
Z9 2
U1 0
U2 1
PU CARBONE EDITORE
PI PALERMO
PA VIA QUINTINO SELLA, 68, PALERMO, 90139, ITALY
SN 0393-6384
EI 2283-9720
J9 ACTA MEDICA MEDITERR
JI Acta Medica Mediterr.
PY 2018
VL 34
IS 5
BP 1221
EP 1226
DI 10.19193/0393-6384_2018_5_187
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA GL3JV
UT WOS:000437030700009
DA 2025-06-11
ER

PT J
AU Lambertz, J
   Weiskirchen, S
   Landert, S
   Weiskirchen, R
AF Lambertz, Jessica
   Weiskirchen, Sabine
   Landert, Silvano
   Weiskirchen, Ralf
TI Fructose: A Dietary Sugar in Crosstalk with Microbiota Contributing to
   the Development and Progression of Non-Alcoholic Liver Disease
SO FRONTIERS IN IMMUNOLOGY
LA English
DT Review
DE fructose; gut-liver-axis; inulin; insulin resistance; microbiota; SCFA;
   probiotics; prebiotics
ID CHAIN FATTY-ACIDS; INTESTINAL BARRIER FUNCTION; ACTIVATED
   PROTEIN-KINASE; GUT MICROBIOTA; URIC-ACID; AKKERMANSIA-MUCINIPHILA;
   HEPATIC STEATOSIS; OXIDATIVE STRESS; OBESITY; HOST
AB Fructose is one of the key dietary catalysts in the development of non-alcoholic fatty liver disease (NAFLD). NAFLD comprises a complex disease spectrum, including steatosis (fatty liver), non-alcoholic steatohepatitis, hepatocyte injury, inflammation, and fibrosis. It is also the hepatic manifestation of the metabolic syndrome, which covers abdominal obesity, insulin resistance, dyslipidemia, glucose intolerance, or type 2 diabetes mellitus. Commensal bacteria modulate the host immune system, protect against exogenous pathogens, and are gatekeepers in intestinal barrier function and maturation. Dysbalanced intestinal microbiota composition influences a variety of NAFLD-associated clinical conditions. Conversely, nutritional supplementation with probiotics and preobiotics impacting composition of gut microbiota can improve the outcome of NAFLD. In crosstalk with the host immune system, the gut microbiota is able to modulate inflammation, insulin resistance, and intestinal permeability. Moreover, the composition of microbiota of an individual is a kind of fingerprint highly influenced by diet. In addition, not only the microbiota itself but also its metabolites influence the metabolism and host immune system. The gut microbiota can produce vitamins and a variety of nutrients including short-chain fatty acids. Holding a healthy balance of the microbiota is therefore highly important. In the present review, we discuss the impact of long-term intake of fructose on the composition of the intestinal microbiota and its biological consequences in regard to liver homeostasis and disease. In particular, we will refer about fructose-induced alterations of the tight junction proteins affecting the gut permeability, leading to the translocation of bacteria and bacterial endotoxins into the blood circulation.
C1 [Lambertz, Jessica; Weiskirchen, Sabine; Weiskirchen, Ralf] RWTH Univ Hosp Aachen, Inst Mol Pathobiochem Expt Gene Therapy & Clin Ch, Aachen, Germany.
   [Landert, Silvano] Culture Collect Switzerland AG CCOS, Wadenswil, Switzerland.
C3 RWTH Aachen University; RWTH Aachen University Hospital
RP Weiskirchen, R (corresponding author), RWTH Univ Hosp Aachen, Inst Mol Pathobiochem Expt Gene Therapy & Clin Ch, Aachen, Germany.
EM rweiskirchen@ukaachen.de
RI Weiskirchen, Ralf/O-1734-2018
OI Weiskirchen, Ralf/0000-0003-3888-0931; Weiskirchen,
   Sabine/0000-0002-6374-3413
FU German Research Foundation (DFG) [SFB/TRR 57 P13, Q3]; Interdisciplinary
   Centre for Clinical Research (IZKF) within the Faculty of Medicine at
   the RWTH Aachen University [E7-6]; Austrian Science Fund (FWF) [Q3]
   Funding Source: Austrian Science Fund (FWF)
FX RW is supported by grants from the German Research Foundation (DFG,
   SFB/TRR 57 P13 and Q3) and the Interdisciplinary Centre for Clinical
   Research (IZKF) within the Faculty of Medicine at the RWTH Aachen
   University (E7-6). None of the funding sources exerted influence on
   content of this review or decision to submit this article for
   publication.
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NR 103
TC 133
Z9 140
U1 5
U2 67
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-3224
J9 FRONT IMMUNOL
JI Front. Immunol.
PD SEP 19
PY 2017
VL 8
AR 1159
DI 10.3389/fimmu.2017.01159
PG 17
WC Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology
GA FH3PR
UT WOS:000411062200001
PM 28970836
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Hu, ML
   Lin, HX
   Yang, L
   Cheng, YZ
   Zhang, H
AF Hu, Minling
   Lin, Hanxiao
   Yang, Li
   Cheng, Yanzhen
   Zhang, Hua
TI Interleukin-22 restored mitochondrial damage and impaired
   glucose-stimulated insulin secretion through down-regulation of
   uncoupling protein-2 in INS-1 cells
SO JOURNAL OF BIOCHEMISTRY
LA English
DT Article
DE interleukin-22; palmitate; glucose-stimulated insulin secretion;
   mitochondrial membrane potential; uncoupling protein-2
ID FREE FATTY-ACIDS; PANCREATIC-ISLETS; METABOLIC SYNDROME; TH17 CYTOKINE;
   BETA-CELLS; UCP2; MICE; DYSFUNCTION; OBESITY; OVEREXPRESSION
AB Defective glucose-stimulated insulin secretion (GSIS) induced by chronic exposure to fatty acids is a hallmark of type 2 diabetes (T2D). Interleukin-22 (IL-22) has been shown to exert beneficial effects on insulin secretion and to protect pancreatic beta-cells from stress. Moreover, uncoupling protein-2 (UCP-2) plays a central role in the regulation of GSIS and beta-cell dysfunction, whereas the role of UCP-2 in IL-22-enhanced glycemic control under conditions of lipotoxicity remains unclear. In this present study, we investigated the effects of IL-22 on rat insulin-secreting cells (INS-1 cells) and the mechanisms that underlie IL-22 and lipotoxicity-impaired GSIS in vitro. Chronic palmitate (PA) treatment impaired insulin secretion and activated UCP-2 expression in INS-1 cells. Furthermore, in INS-1 cells, both reduced mitochondrial membrane potential (Delta I<spacing diaeresis>(m)) and impaired GSIS induced by PA treatment were effectively reversed by an inhibitor of UCP-2 (genipin). Additionally, compared with the PA-treated group, INS-1 cells treated with IL-22 down-regulated UCP-2 expression, increased mitochondrial membrane potential, and restored GSIS. Together, our findings indicate that chronic exposure to PA could activate UCP-2, resulting in mitochondrial damage and impaired GSIS in INS-1 cells. We also suggest that IL-22 plays a protective role in this process via the down-regulation of UCP-2.
C1 [Hu, Minling] Clin Med Guangdong Pharmaceut Univ, Dept Endocrinol, Affiliated Hosp 1, Guangzhou 510080, Guangdong, Peoples R China.
   [Lin, Hanxiao] Guangzhou Med Univ, Guangzhou Peoples Hosp 1, Dept Nutr, 602 Ren Min Bei Rd, Guangzhou 510180, Guangdong, Peoples R China.
   [Yang, Li; Cheng, Yanzhen; Zhang, Hua] Southern Med Univ, Zhujiang Hosp, Dept Endocrinol, S253 Ind Blvd, Guangzhou 510282, Guangdong, Peoples R China.
C3 Guangzhou Medical University; Southern Medical University - China
RP Zhang, H (corresponding author), Southern Med Univ, Zhujiang Hosp, Dept Endocrinol, S253 Ind Blvd, Guangzhou 510282, Guangdong, Peoples R China.
EM jimzhua123@163.com
FU Guangdong Provincial Department of Science and Technology
   [2015A020212023]; Guangzhou Science Technology and Innovation Commission
   [2014J4100129]
FX This work was supported by Guangdong Provincial Department of Science
   and Technology (No. 2015A020212023), and Guangzhou Science Technology
   and Innovation Commission (No. 2014J4100129).
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NR 41
TC 16
Z9 17
U1 0
U2 16
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0021-924X
EI 1756-2651
J9 J BIOCHEM
JI J. Biochem.
PD MAY
PY 2017
VL 161
IS 5
BP 433
EP 439
DI 10.1093/jb/mvw084
PG 7
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA EY5UV
UT WOS:000404046900005
PM 28069865
DA 2025-06-11
ER

PT J
AU Wang, Z
   Ka, SO
   Lee, Y
   Park, BH
   Bae, EJ
AF Wang, Zheng
   Ka, Sun-O
   Lee, Youngyi
   Park, Byung-Hyun
   Bae, Eun Ju
TI Butein induction of HO-1 by p38 MAPK/Nrf2 pathway in adipocytes
   attenuates high-fat diet induced adipose hypertrophy in mice
SO EUROPEAN JOURNAL OF PHARMACOLOGY
LA English
DT Article
DE Butein; HO-1; Nrf2; P38 MAPK; Adipose hypertrophy; Glucose intolerance
ID IMPROVES INSULIN SENSITIVITY; HEME OXYGENASE-1 GENE; UP-REGULATION;
   NRF2; CELLS; INFLAMMATION; ADIPONECTIN; INHIBITION; EXPRESSION;
   DYSFUNCTION
AB Adipose tissue inflammation and oxidative stress are key components in the development of obesity and insulin resistance. Heme oxygenase (HO)-1 in adipocytes protects against obesity and adipose dysfunction. In this study, we report the identification of butein, a flavonoid chalcone, as a novel inducer of HO-1 expression in adipocytes in vitro and in vivo. Butein upregulated HO-1 mRNA and protein expression in 3T3-L1 adipocytes, accompanied by Kelch-Like ECH-Associated Protein (Keap) 1 degradation and increase in the nuclear level of nuclear factor erythroid 2-related factor 2 (Nrf2). Butein modulation of Keapl and Nrf2 as well as HO-1 upregulation was reversed by pretreatment with p38 MAPK inhibitor SB203580, indicating the involvement of p38 MAPK in butein activation of Nrf2 in adipocytes. In addition, HO-1 activation by butein led to the inhibitions of reactive oxygen species and adipocyte differentiation, as evidenced by the fact that butein repression of reactive oxygen species and adipogenesis was reversed by pretreatment with HO-1 inhibitor SnPP. Induction of HO-1 expression by butein was also demonstrated in the adipose tissue of C57BL/6 mice fed a high-fat diet administered along with butein for three weeks, and correlated with the inhibitions of adiposity and adipose tissue inflammation, which were reversed by co-administration of SnPP. Altogether, our results demonstrate that butein activates the p38 MAPK/Nrf2/H0-1 pathway to act as a potent inhibitor of adipose hypertrophy and inflammation in a diet-induced obesity model and thus has potential for suppressing obesity linked metabolic syndrome.
C1 [Wang, Zheng; Bae, Eun Ju] Woosuk Univ, Coll Pharm, Wonju, South Korea.
   [Ka, Sun-O; Lee, Youngyi; Park, Byung-Hyun] Chonbuk Natl Univ, Sch Med, Jeonju, South Korea.
C3 Woosuk University; Jeonbuk National University
RP Bae, EJ (corresponding author), Woosuk Univ, Coll Pharm, Wonju, South Korea.
EM ejbae@woosuk.ac.kr
OI Bae, Eun Ju/0000-0003-1693-8290; Wang, Zheng/0000-0002-8649-5862
FU National Research Foundation of Korea Grant - Korean Government
   [NRF-2012R1A1A1014527, 2014R1A1A3053867]
FX This research was supported by the National Research Foundation of Korea
   Grant funded by the Korean Government (NRF-2012R1A1A1014527 and
   2014R1A1A3053867).
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NR 46
TC 61
Z9 62
U1 0
U2 40
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0014-2999
EI 1879-0712
J9 EUR J PHARMACOL
JI Eur. J. Pharmacol.
PD MAR 15
PY 2017
VL 799
BP 201
EP 210
DI 10.1016/j.ejphar.2017.02.021
PG 10
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA EO8OQ
UT WOS:000396949500025
PM 28213287
DA 2025-06-11
ER

PT J
AU Mirmiran, P
   Khalili Moghadam, S
   Bahadoran, Z
   Tohidi, M
   Azizi, F
AF Mirmiran, Parvin
   Khalili Moghadam, Sajjad
   Bahadoran, Zahra
   Tohidi, Maryam
   Azizi, Fereidoun
TI Association of dietary carotenoids and the incidence of insulin
   resistance in adults: Tehran lipid and glucose study
SO NUTRITION & DIETETICS
LA English
DT Article
DE carotenoid; insulin; insulin resistance index
ID HOMEOSTASIS MODEL ASSESSMENT; OXIDATIVE STRESS; BETA-CAROTENE;
   CARDIOVASCULAR-DISEASE; PLASMA-CONCENTRATIONS; METABOLIC SYNDROME; SERUM
   CAROTENOIDS; HIGH-RISK; ANTIOXIDANTS; SENSITIVITY
AB Aim: Carotenoids may reduce the risk of insulin resistance (IR) due to their antioxidant properties. The aim of the present study was to investigate the relationship between dietary intake of carotenoids and the risk of IR in Iranian adults.
   Methods: In this longitudinal study, 1106 men and women, aged 19-74 years, were studied within the framework of Tehran Lipid and Glucose Study among Tehran an adults. Fasting serum insulin and glucose were measured at baseline and again after three years of follow up; IR was defined according to optimal cut-off values. The usual dietary intake of carotenoids including alpha-carotene, beta-carotene, lycopene, lutein and beta-cryptoxanthin was measured using a validated 168-item semi-quantitative food frequency questionnaire. Logistic regression models were used to estimate the occurrence of IR across tertiles of carotenoids with adjustment for potential confounding variables.
   Results: Mean age of participants was 40.71 +/- 12.14 years, and mean body mass index was 27.23 +/- 4.9 kg/m(2), at baseline. Mean intake of total carotenoids was 10.1 +/- 7.3 mg/day. Highest compared to the lowest dietary intake of -carotene was significantly associated with a lower risk of IR (OR = 0.42, 95% CI = 0.25-0.72, P for trend = 0.01). Higher intake of beta-cryptoxanthin was also significantly associated with a lower risk of IR (OR = 0.51, 95% CI = 0.30-0.84, P for trend = 0.01).
   Conclusions: Higher consumption of dietary carotenoids such as beta-carotene and beta-cryptoxanthin may be associated with a reduced risk of IR.
C1 [Mirmiran, Parvin; Khalili Moghadam, Sajjad; Bahadoran, Zahra] Shahid Beheshti Univ Med Sci, Nutr & Endocrine Res Ctr, Tehran, Iran.
   [Mirmiran, Parvin; Khalili Moghadam, Sajjad; Bahadoran, Zahra] Shahid Beheshti Univ Med Sci, Obes Res Ctr, Tehran, Iran.
   [Tohidi, Maryam] Shahid Beheshti Univ Med Sci, Prevent Metab Disorders Res Ctr, Tehran, Iran.
   [Azizi, Fereidoun] Shahid Beheshti Univ Med Sci, Res Inst Endocrine Sci, Endocrine Res Ctr, Tehran, Iran.
C3 Shahid Beheshti University Medical Sciences; Shahid Beheshti University
   Medical Sciences; Shahid Beheshti University Medical Sciences; Shahid
   Beheshti University Medical Sciences
RP Bahadoran, Z (corresponding author), Shahid Beheshti Univ Med Sci, Res Inst Endocrine Sci, POB 19395-4763, Tehran, Iran.
EM z.bahadoran@endocrine.ac.ir
RI Tohidi, Maryam/V-2261-2019; Mirmiran, Parvin/V-1433-2019; Bahadoran,
   Zahra/V-2003-2019; Azizi, Fereidoun/ABD-4136-2021
OI Azizi, Fereidoun/0000-0002-6470-2517; khalili moghadam,
   sajad/0000-0002-3722-5153; Mirmiran, Parvin/0000-0003-2391-4924
FU National Research Council of the Islamic Republic of Iran [121];
   Research Institute for Endocrine Sciences of Shahid Beheshti University
   of Medical Sciences
FX The present study was supported by Grant No. 121 from the National
   Research Council of the Islamic Republic of Iran and the Research
   Institute for Endocrine Sciences of Shahid Beheshti University of
   Medical Sciences.
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NR 40
TC 6
Z9 6
U1 0
U2 8
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1446-6368
EI 1747-0080
J9 NUTR DIET
JI Nutr. Diet.
PD APR
PY 2016
VL 73
IS 2
BP 162
EP 168
DI 10.1111/1747-0080.12244
PG 7
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA DK6UT
UT WOS:000375061700007
DA 2025-06-11
ER

PT J
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AF Mai, Jietang
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   Autieri, Michael V.
   Kunapuli, Satya P.
   Iwakura, Yoichiro
   Jiang, Xiaohua
   Wang, Hong
   Yang, Xiao-Feng
TI Interleukin-17A Promotes Aortic Endothelial Cell Activation via
   Transcriptionally and Post-translationally Activating p38
   Mitogen-activated Protein Kinase (MAPK) Pathway
SO JOURNAL OF BIOLOGICAL CHEMISTRY
LA English
DT Article
DE cardiovascular disease; endothelial cell; inflammation; interleukin 17A
   (IL-17 or IL-17A); p38 MAPK; endothelial cell activation; monocyte
   adhesion
ID E-DEFICIENT MICE; APOLIPOPROTEIN-E; SEVERE HYPERCHOLESTEROLEMIA;
   METABOLIC SYNDROME; VASCULAR FUNCTION; ATHEROSCLEROSIS; INFLAMMATION;
   IL-17; HYPERHOMOCYSTEINEMIA; DYSFUNCTION
AB Interleukin-17 (IL-17)-secreting T helper 17 cells were recently identified as a CD4(+) T helper subset and implicated in various inflammatory and autoimmune diseases. The issues of whether and by what mechanism hyperlipidemic stress induces IL-17A to activate aortic endothelial cells (ECs) and enhance monocyte adhesion remained largely unknown. Using biochemical, immunological, microarray, experimental data mining analysis, and pathological approaches focused on primary human and mouse aortic ECs (HAECs and MAECs) and our newly generated apolipoprotein E (ApoE)(-/-)/IL-17A(-/-) mice, we report the following new findings. 1) The hyperlipidemia stimulus oxidized low density lipoprotein up-regulated IL-17 receptor(s) in HAECs and MAECs. 2) IL-17A activated HAECs and increased human monocyte adhesion in vitro. 3) A deficiency of IL-17A reduced leukocyte adhesion to endothelium in vivo. 3) IL-17A activated HAECs and MAECs via up-regulation of proinflammatory cytokines IL-6, granulocyte-macrophage colony-stimulating factor (GM-CSF), chemokine CXC motif ligand 1 (CXCL1), and CXCL2. 4) IL-17A activated ECs specifically via the p38 mitogen-activated protein kinases (MAPK) pathway; the inhibition of p38 MAPK in ECs attenuated IL-17A-mediated activation by ameliorating the expression of the aforementioned proinflammatory cytokines, chemokines, and EC adhesion molecules including intercellular adhesion molecule 1. Taken together, our results demonstrate for the first time that IL-17A activates aortic ECs specifically via p38 MAPK pathway.
C1 [Mai, Jietang; Nanayakkara, Gayani; Lopez-Pastrana, Jahaira; Li, Xinyuan; Li, Ya-Feng; Wang, Xin; Song, Ai; Virtue, Anthony; Shao, Ying; Shan, Huimin; Liu, Fang; Kunapuli, Satya P.; Jiang, Xiaohua; Wang, Hong; Yang, Xiao-Feng] Temple Univ, Lewis Katz Sch Med, Ctr Metab Dis Res, MERB 1059,3500 N Broad St, Philadelphia, PA 19140 USA.
   [Mai, Jietang; Nanayakkara, Gayani; Lopez-Pastrana, Jahaira; Li, Xinyuan; Li, Ya-Feng; Wang, Xin; Song, Ai; Virtue, Anthony; Shao, Ying; Shan, Huimin; Liu, Fang; Kunapuli, Satya P.; Jiang, Xiaohua; Wang, Hong; Yang, Xiao-Feng] Temple Univ, Lewis Katz Sch Med, Ctr Cardiovasc Res, MERB 1059,3500 N Broad St, Philadelphia, PA 19140 USA.
   [Mai, Jietang; Nanayakkara, Gayani; Lopez-Pastrana, Jahaira; Li, Xinyuan; Li, Ya-Feng; Wang, Xin; Song, Ai; Virtue, Anthony; Shao, Ying; Shan, Huimin; Liu, Fang; Kunapuli, Satya P.; Jiang, Xiaohua; Wang, Hong; Yang, Xiao-Feng] Temple Univ, Lewis Katz Sch Med, Ctr Thrombosis Res, Philadelphia, PA 19140 USA.
   [Mai, Jietang; Li, Xinyuan; Virtue, Anthony; Wang, Hong; Yang, Xiao-Feng] Temple Univ, Lewis Katz Sch Med, Dept Pharmacol, Philadelphia, PA 19140 USA.
   [Autieri, Michael V.; Kunapuli, Satya P.] Temple Univ, Lewis Katz Sch Med, Dept Physiol, Philadelphia, PA 19140 USA.
   [Iwakura, Yoichiro] Univ Tokyo, Inst Med Sci, Ctr Expt Med, Tokyo 1088639, Japan.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE); Temple
   University; Pennsylvania Commonwealth System of Higher Education
   (PCSHE); Temple University; Pennsylvania Commonwealth System of Higher
   Education (PCSHE); Temple University; Pennsylvania Commonwealth System
   of Higher Education (PCSHE); Temple University; Pennsylvania
   Commonwealth System of Higher Education (PCSHE); Temple University;
   University of Tokyo
RP Yang, XF (corresponding author), Temple Univ, Lewis Katz Sch Med, Ctr Metab Dis Res, MERB 1059,3500 N Broad St, Philadelphia, PA 19140 USA.; Yang, XF (corresponding author), Temple Univ, Lewis Katz Sch Med, Ctr Cardiovasc Res, MERB 1059,3500 N Broad St, Philadelphia, PA 19140 USA.
EM xfyang@temple.edu
RI Li, Xinyuan/Z-6299-2019; iwakura, yoichiro/E-5457-2011; Li,
   Ya-Feng/J-6247-2013; Li, Xinyuan/B-1139-2015
OI iwakura, yoichiro/0000-0002-9934-5775; Li, Ya-Feng/0000-0002-7500-0959;
   Li, Xinyuan/0000-0002-6746-8367
FU National Institutes of Health Grants [5R01HL108910-05, 5R01HL116917-03,
   1R01DK104116-01A1, 5R01HL077288-11, 5R01HL110764-05, 5R01HL117654-03,
   1R01HL131460-01]; American Heart Association predoctoral/postdoctoral
   fellowships; Grants-in-Aid for Scientific Research [15H05787] Funding
   Source: KAKEN
FX This work was supported by the National Institutes of Health Grants
   5R01HL108910-05, 5R01HL116917-03, 1R01DK104116-01A1, 5R01HL077288-11,
   5R01HL110764-05, 5R01HL117654-03, and 1R01HL131460-01 (to X.-F. Y. and
   H. W.) and American Heart Association predoctoral/postdoctoral
   fellowships (to J. M., A. V., and Y. L.). The authors declare that they
   have no conflicts of interests. The content is solely the responsibility
   of the authors and does not necessarily represent the official views of
   the National Institutes of Health.
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NR 49
TC 65
Z9 70
U1 1
U2 17
PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3996 USA
EI 1083-351X
J9 J BIOL CHEM
JI J. Biol. Chem.
PD MAR 4
PY 2016
VL 291
IS 10
BP 4939
EP 4954
DI 10.1074/jbc.M115.690081
PG 16
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA DF8WF
UT WOS:000371640600010
PM 26733204
OA Green Published
DA 2025-06-11
ER

PT J
AU Razmpoosh, E
   Javadi, M
   Ejtahed, HS
   Mirmiran, P
AF Razmpoosh, Elham
   Javadi, Maryam
   Ejtahed, Hanieh-Sadat
   Mirmiran, Parvin
TI Probiotics as beneficial agents in the management of diabetes mellitus:
   a systematic review
SO DIABETES-METABOLISM RESEARCH AND REVIEWS
LA English
DT Review
DE probiotics; diabetes; hyperglycemia; onset of diabetes; lipid profile
ID LACTIC-ACID BACTERIA; CASEI STRAIN SHIROTA; LACTOBACILLUS-CASEI;
   BLOOD-GLUCOSE; INSULIN-RESISTANCE; OXIDATIVE STRESS; LIPID PROFILE;
   DOUBLE-BLIND; INFLAMMATORY MARKERS; METABOLIC SYNDROME
AB Probiotics have been suggested to play an important role in the management of diabetes. We conducted a systematic review on the role of probiotics in modulating parameters related to diabetes in animal and human experiments. We searched Pubmed, Scopus and Cochrane central until June 2014, concerning the effects of probiotics on hyperglycemia, hyperinsulinemia and their anti-diabetic efficacies by modulating the activities of proinflammatory and antioxidant factors. Our initial search retrieved 1120 reports. After screening titles and abstracts, 72 full-text articles were reviewed for eligibility. Ultimately, 33 articles met our inclusion criteria consisting of five human and twenty eight animal reports. Lactobacillus strains were, in particular, used in all studies with or without other strains. We found that probiotics have beneficial effects on glycemic controls, as all human studies showed significant reductions in at least one of the primary outcome endpoints which were the levels of fasting plasma glucose, postprandial blood glucose, glycated haemoglobin, insulin, insulin resistance and onset of diabetes; similarly, all the animal reports, except for two, documented significant changes in these parameters. Regarding secondary outcome measures, that is, lipid profiles, pro-inflammatory and anti-oxidant factors, only one human and one animal study failed to show any significant changes in any of these parameters. This systematic review generally demonstrated beneficial effects of the probiotic administration, especially Lactobacillus sub-strains, on the management of diabetes-related blood parameters, although, more evidence, especially from human trials, is needed to confirm these effects and also to conduct a meta-analysis. Copyright (c) 2015 John Wiley & Sons, Ltd.
C1 [Razmpoosh, Elham; Javadi, Maryam] Qazvin Univ Med Sci, Children Growth Res Ctr, Qazvin, Iran.
   [Ejtahed, Hanieh-Sadat] Univ Tehran Med Sci, Obes & Eating Habits Res Ctr, Endocrinol & Metab Mol Cellular Sci Inst, Tehran, Iran.
   [Ejtahed, Hanieh-Sadat] Univ Tehran Med Sci, Endocrinol & Metab Res Ctr, Endocrinol & Metab Clin Sci Inst, Tehran, Iran.
   [Mirmiran, Parvin] Shahid Beheshti Univ Med Sci, Nutr & Endocrine Res Ctr, Res Inst Endocrine Sci, Tehran, Iran.
   [Mirmiran, Parvin] Shahid Beheshti Univ Med Sci, Fac Nutr Sci & Food Technol, Natl Nutr & Food Technol Res Inst, Dept Nutr & Clin Dietet, Tehran, Iran.
C3 Qazvin University of Medical Sciences (QUMS); Tehran University of
   Medical Sciences; Tehran University of Medical Sciences; Shahid Beheshti
   University Medical Sciences; Shahid Beheshti University Medical Sciences
RP Mirmiran, P (corresponding author), Shahid Beheshti Univ Med Sci, Nutr & Endocrine Res Ctr, Res Inst Endocrine Sci, Tehran, Iran.; Mirmiran, P (corresponding author), Shahid Beheshti Univ Med Sci, Fac Nutr Sci & Food Technol, Natl Nutr & Food Technol Res Inst, Dept Nutr & Clin Dietet, Tehran, Iran.
EM mirmiran@endocrine.ac.ir
RI Mirmiran, Parvin/V-1433-2019; ejtahed, hanieh/AAH-4921-2021; Javadi,
   Maryam/HPG-6494-2023; Razmpoosh, Elham/S-4133-2016
OI Ejtahed, Hanieh-Sadat/0000-0002-6395-4915; Razmpoosh,
   Elham/0000-0001-5476-2973; Mirmiran, Parvin/0000-0003-2391-4924; Javadi,
   Maryam/0000-0002-7185-8472
FU Research Institute for Endocrine Sciences, Shahid Beheshti University of
   Medical Sciences, Tehran, Iran; Qazvin University of Medical Sciences,
   Qazvin, Iran
FX The financial supports are from the Research Institute for Endocrine
   Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
   and the Qazvin University of Medical Sciences, Qazvin, Iran.
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NR 90
TC 63
Z9 67
U1 0
U2 52
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1520-7552
EI 1520-7560
J9 DIABETES-METAB RES
JI Diabetes-Metab. Res. Rev.
PD FEB
PY 2016
VL 32
IS 2
BP 143
EP 168
DI 10.1002/dmrr.2665
PG 26
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA DE6BC
UT WOS:000370716800003
PM 25963407
DA 2025-06-11
ER

PT J
AU Silva-Costa, A
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   Griep, RH
AF Silva-Costa, Aline
   Rotenberg, Lucia
   Nobre, Aline Araujo
   Schmidt, Maria Ines
   Chor, Dora
   Griep, Rosane Haerter
TI Gender-specific association between night-work exposure and type-2
   diabetes: results from longitudinal study of adult health, ELSA-Brasil
SO SCANDINAVIAN JOURNAL OF WORK ENVIRONMENT & HEALTH
LA English
DT Article
DE Brazil; impaired glucose tolerance; night shift; sex differences; work
   schedule
ID SHIFT WORK; METABOLIC SYNDROME; CARDIOVASCULAR-DISEASE;
   INSULIN-RESISTANCE; RISK; MELLITUS; OBESITY; WOMEN; PREVALENCE; STRESS
AB Objectives Diabetes is a multifactorial disease of increasing prevalence. The literature suggests an impact of night work on metabolic components, though the relationship with diabetes is unclear. Our aim was to investigate gender-specific associations between night work and type-2 diabetes (DM2) or impaired glucose tolerance (IGT) using baseline data of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil).
   Methods The cohort comprised 15 105 civil servants, aged 35-74 years. Baseline assessments (2008-2010) included clinical and laboratory measurements and interviews on sociodemographic, occupational, and health characteristics.
   Results In the baseline sample (N=14 427), 19.6% were classified as having DM2 and 20.5% as having IGT. Mean age was 52.1 (SD 9.1) years. A total of 2041 participants worked at night for 1-20 years and 687 for >20 years. Among women exposed to night work for >20 years compared with no night work after adjustments for potential confounders, including obesity, the odds ratios (OR) derived from multinomial logistic regression for DM2 and IGT were 1.42 [95% confidence interval (95% CI) 1.39-1.45] and 0.96 (95% CI 0.94-0.99), respectively. Among men exposed to night work for >20 years compared with no night work, the OR for DM2 and IGT were 1.06 (95% CI 1.04-1.08) and 0.99 (95% CI 0.98-1.01), respectively.
   Conclusions The association between years of night work and diabetes is stronger among women than men. Longitudinal studies from ELSA-Brasil will be able to corroborate or refute these findings.
C1 [Silva-Costa, Aline] Fiocruz MS, Oswaldo Cruz Fdn ENSP, Natl Sch Publ Hlth, BR-21045900 Rio De Janeiro, RJ, Brazil.
   [Rotenberg, Lucia] Fiocruz MS, Inst Oswaldo Cruz, Lab Hlth & Environm Educ, BR-21045900 Rio De Janeiro, RJ, Brazil.
   [Nobre, Aline Araujo] Fiocruz MS, Oswaldo Cruz Fdn, Comp Sci Program, BR-21045900 Rio De Janeiro, RJ, Brazil.
   [Schmidt, Maria Ines] Univ Fed Rio Grande do Sul, Sch Med, Postgrad Programme Epidemiol, Porto Alegre, RS, Brazil.
   [Chor, Dora] Fiocruz MS, Oswaldo Cruz Fdn, Dept Epidemiol, Natl Sch Publ Hlth, BR-21045900 Rio De Janeiro, RJ, Brazil.
   [Griep, Rosane Haerter] Fiocruz MS, Inst Oswaldo Cruz, Lab Hlth & Environm Educ, BR-21045900 Rio De Janeiro, RJ, Brazil.
C3 Fundacao Oswaldo Cruz; Fundacao Oswaldo Cruz; Fundacao Oswaldo Cruz;
   Universidade Federal do Rio Grande do Sul; Fundacao Oswaldo Cruz;
   Fundacao Oswaldo Cruz
RP Silva-Costa, A (corresponding author), Fiocruz MS, Oswaldo Cruz Fdn ENSP, Natl Sch Publ Hlth, Av Brasil 4365,Pavilhao Lauro Travassos, BR-21045900 Rio De Janeiro, RJ, Brazil.
EM alinecos@ioc.fiocruz.br
RI Rotenberg, Lucia/GVS-2615-2022; Griep, Rosane/ABB-4509-2020; Schmidt,
   Maria/V-3196-2019; Griep, Rosane Harter/E-3763-2013
OI Silva-Costa, Aline/0000-0003-1753-3922; Reis,
   AlessanRSS/0000-0001-8486-7469; Griep, Rosane Harter/0000-0002-6250-2036
FU Brazilian Ministry of Health (Science and Technology Department);
   Brazilian Ministry of Science and Technology (Financiadora de Estudos e
   Projetos) [01 06 0010.00 RS, 0106 0212.00 BA, 01 06 0300.00 ES, 01 06
   0278.00 MG, 01 06 0115.00 SP, 01 06 0071.00 RJ]; Carlos Chagas Filho
   Foundation for Research Support in the State of Rio de Janeiro (FAPERJ)
   [E26/100.448/2014]; Brazilian Ministry of Science and Technology (CNPq
   National Research Council) [01 06 0010.00 RS, 0106 0212.00 BA, 01 06
   0300.00 ES, 01 06 0278.00 MG, 01 06 0115.00 SP, 01 06 0071.00 RJ]
FX The Brazilian Ministry of Health (Science and Technology Department) and
   the Brazilian Ministry of Science and Technology (Financiadora de
   Estudos e Projetos and CNPq National Research Council) supported the
   ELSA-Brasil baseline [grants 01 06 0010.00 RS, 0106 0212.00 BA, 01 06
   0300.00 ES, 01 06 0278.00 MG, 01 06 0115.00 SP, 01 06 0071.00 RJ]. The
   first author is the recipient of scholarships from Carlos Chagas Filho
   Foundation for Research Support in the State of Rio de Janeiro (FAPERJ -
   E26/100.448/2014). The funding source had no influence on study design,
   data collection, analysis and interpretation, writing the paper nor in
   the decision to publish, and the authors declare no conflict of
   interest.
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NR 38
TC 26
Z9 30
U1 0
U2 10
PU SCANDINAVIAN JOURNAL WORK ENVIRONMENT & HEALTH
PI HELSINKI
PA TOPELIUKSENKATU 41A, SF-00250 HELSINKI, FINLAND
SN 0355-3140
EI 1795-990X
J9 SCAND J WORK ENV HEA
JI Scand. J. Work Environ. Health
PD NOV
PY 2015
VL 41
IS 6
BP 569
EP 578
DI 10.5271/sjweh.3520
PG 10
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA CV1EY
UT WOS:000363997700008
PM 26313566
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Kim, KN
   Park, SJ
   Choi, B
   Joo, NS
AF Kim, Kyu-Nam
   Park, Soo-Jung
   Choi, Beomhee
   Joo, Nam-Seok
TI Blood Mercury and Insulin Resistance in Nondiabetic Koreans (KNHANES
   2008-2010)
SO YONSEI MEDICAL JOURNAL
LA English
DT Article
DE Mercury; insulin resistance; environment; inflammation; Korean
ID CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; OXIDATIVE STRESS; FISH;
   INFLAMMATION; HEALTH; RISK; HYPERTENSION; EXPOSURE; DIOXINS
AB Purpose: Blood mercury levels are associated with inflammation, and chronic low-grade inflammation is a cause of insulin resistance. This study aimed to investigate the association between serum mercury and insulin resistance. Materials and Methods: Subjects from the 2008-2010 Korean National Health and Nutrition Examination Survey were selected (n=29235) and the relevant data of 5388 subjects (2643 males and 2745 females) were analyzed cross-sectionally. Homeostasis Model Assessment for Insulin Resistance (HOMA-IR) was compared according to blood mercury quartiles, and the odds ratio (OR) of having the highest quartile of HOMA-IR according to blood mercury quartiles was calculated. Results: Blood mercury levels in men and women were 29.4 nmol/L and 20.5 nmol/L, respectively, and fasting blood sugar (PBS), insulin, and HOMA-IR were significantly correlated with blood mercury levels. The correlation was stronger in men than in women. In men, PBS and HOMA-IR showed step-wise increases as the quartiles of blood mercury increased; only HOMA-IR differed significantly in the third and fourth blood mercury quartiles, compared to the first quartile. In women, however, both FBS and HOMA-IR differed significantly in the third and fourth blood mercury quartiles, compared to the first quartile. Among men, the OR of being in the highest HOMA-IR quartile was greatest for the highest blood mercury quartile (OR=1.720, 95% CI; 1.172-2.526), compared with the lowest quartile. Conclusion: In this large population-based study, blood mercury levels were weakly correlated with HOMA-IR and may be a risk factor for insulin resistance in nondiabetic Koreans.
C1 [Kim, Kyu-Nam; Park, Soo-Jung; Joo, Nam-Seok] Ajou Univ, Sch Med, Dept Family Practice & Community Hlth, Suwon 443380, South Korea.
   [Choi, Beomhee] CHA Univ, CHA Antiaging Inst, Seoul, South Korea.
C3 Ajou University; Pochon Cha University
RP Joo, NS (corresponding author), Ajou Univ, Sch Med, Dept Family Practice & Community Hlth, 164 World Cup Ro, Suwon 443380, South Korea.
EM jchcmc@hanmail.net
FU Cooperative Research Program for Agriculture Science & Technology
   Development, Rural Development Administration, Republic of Korea
   [PJ010059]
FX This work was carried out with support from the Cooperative Research
   Program for Agriculture Science & Technology Development (PJ010059),
   Rural Development Administration, Republic of Korea.
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PI SEOUL
PA 50-1 YONSEI-RO, SEODAEMUN-GU, SEOUL 120-752, SOUTH KOREA
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WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA CL4DM
UT WOS:000356902800009
PM 26069115
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Chao, J
   Chai, TC
AF Chao, Jamie
   Chai, Toby C.
TI The Future of Research in Female Pelvic Medicine
SO CURRENT UROLOGY REPORTS
LA English
DT Article
DE Female pelvic medicine; Female urology; Pelvic organ prolapse; Urinary
   incontinence
ID NERVE GROWTH-FACTOR; STRESS URINARY-INCONTINENCE; EXTERNAL
   ANAL-SPHINCTER; MYOGENIC STEM-CELLS; LEAK POINT PRESSURE; OVERACTIVE
   BLADDER; ANIMAL-MODEL; WEIGHT-LOSS; VAGINAL MICROBIOTA; METABOLIC
   SYNDROME
AB Female pelvic medicine and reconstructive surgery (FPMRS) was recently recognized as a subspecialty by the American Board of Medical Specialties (ABMS). FPMRS treats female pelvic disorders (FPD) including pelvic organ prolapse (POP), urinary incontinence (UI), fecal incontinence (FI), lower urinary tract symptoms (LUTS), lower urinary tract infections (UTI), pelvic pain, and female sexual dysfunction (FSD). These conditions affect large numbers of individuals, resulting in significant patient, societal, medical, and financial burdens. Given that treatments utilize both medical and surgical approaches, areas of research in FPD necessarily cover a gamut of topics, ranging from mechanistically driven basic science research to randomized controlled trials. While basic science research is slow to impact clinical care, transformational changes in a field occur through basic investigations. On the other hand, clinical research yields incremental changes to clinical care. Basic research intends to change understanding whereas clinical research intends to change practice. However, the best approach is to incorporate both basic and clinical research into a translational program which makes new discoveries and effects positive changes to clinical practice. This review examines current research in FPD, with focus on translational potential, and ponders the future of FPD research. With a goal of improving the care and outcomes in patients with FPD, a strategic collaboration of stakeholders (patients, advocacy groups, physicians, researchers, professional medical associations, legislators, governmental biomedical research agencies, pharmaceutical companies, and medical device companies) is an absolute requirement in order to generate funding needed for FPD translational research.
C1 [Chao, Jamie; Chai, Toby C.] Yale Sch Med, Dept Urol, 789 Howard Ave,POB 208085, New Haven, CT 06519 USA.
   [Chao, Jamie; Chai, Toby C.] Yale Sch Med, Dept Obstet Gynecol & Reprod Sci, New Haven, CT 06510 USA.
C3 Yale University; Yale University
RP Chai, TC (corresponding author), Yale Sch Med, Dept Urol, 789 Howard Ave,POB 208085, New Haven, CT 06519 USA.
EM toby.chai@yale.edu
OI Chai, Toby/0000-0002-1119-546X
FU Allergan; Ion Channels Inc.; Taris Pharmaceutical
FX Dr. Toby C. Chai received a grant from Allergan and personal fees from
   Ion Channels Inc., Allergan, and Taris Pharmaceutical.
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NR 82
TC 0
Z9 0
U1 0
U2 2
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1527-2737
EI 1534-6285
J9 CURR UROL REP
JI Curr. Urol. Rep.
PD FEB
PY 2015
VL 16
IS 2
AR 2
DI 10.1007/s11934-014-0474-6
PG 8
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA VB1DC
UT WOS:000413187700002
PM 25604652
DA 2025-06-11
ER

PT J
AU Gerriets, VA
   MacIver, NJ
AF Gerriets, Valerie A.
   MacIver, Nancie J.
TI Role of T cells in malnutrition and obesity
SO FRONTIERS IN IMMUNOLOGY
LA English
DT Review
DE obesity; inflammation; T cells; malnutrition; leptin
ID PROTEIN-ENERGY MALNUTRITION; INDUCED INSULIN-RESISTANCE;
   NECROSIS-FACTOR-ALPHA; ADIPOSE-TISSUE INFLAMMATION; EXPERIMENTAL
   AUTOIMMUNE ENCEPHALOMYELITIS; TYPE-2 DIABETES-MELLITUS; WELL-NOURISHED
   CHILDREN; IMMUNE-RESPONSE; WEIGHT-LOSS; MACROPHAGE RECRUITMENT
AB Nutritional status is critically important for immune cell function. While obesity is characterized by inflammation that promotes metabolic syndrome including cardiovascular disease and insulin resistance, malnutrition can result in immune cell defects and increased risk of mortality from infectious diseases. T cells play an important role in the immune adaptation to both obesity and malnutrition. T cells in obesity have been shown to have an early and critical role in inducing inflammation, accompanying the accumulation of inflammatory macrophages in obese adipose tissue, which are known to promote insulin resistance. Howl cells are recruited to adipose tissue and activated in obesity is a topic of considerable interest. Conversely, T cell number is decreased in malnourished individuals, and T cells in the setting of malnutrition have decreased effector function and proliferative capacity. The adipokine leptin, which is secreted in proportion to adipocyte mass, may have a key role in mediating adipocyte-T cell interactions in both obesity and malnutrition, and has been shown to promote effector T cell function and metabolism while inhibiting regulatory T cell proliferation. Additionally, key molecular signals are involved in T cell metabolic adaptation during nutrient stress; among them, the metabolic regulator AMP kinase and the mammalian target of rapamycin have critical roles in regulating T cell number, function, and metabolism. In summary, understanding howl cell number and function are altered in obesity and malnutrition will lead to better understanding of and treatment for diseases where nutritional status determines clinical outcome.
C1 [Gerriets, Valerie A.; MacIver, Nancie J.] Duke Univ, Med Ctr, Div Pediat Endocrinol & Diabet, Durham, NC 27710 USA.
C3 Duke University
RP MacIver, NJ (corresponding author), Duke Univ, Med Ctr, Div Pediat Endocrinol & Diabet, Box 102820, Durham, NC 27710 USA.
EM nancie.maciver@duke.edu
RI Gerriets, Valerie/AAD-6611-2019
OI MacIver, Nancie/0000-0003-3676-9391; Gerriets,
   Valerie/0000-0002-1553-2590
FU NIH [K08-DK087944]; Children's Miracle Network
FX This work was supported by NIH K08-DK087944 and the Children's Miracle
   Network. The authors would like to thank Alli Gerriets for help with
   graphics and Jeffrey Rathmell for critical review and useful feedback.
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NR 127
TC 111
Z9 121
U1 1
U2 15
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-3224
J9 FRONT IMMUNOL
JI Front. Immunol.
PD AUG 11
PY 2014
VL 5
AR 379
DI 10.3389/fimmu.2014.00379
PG 11
WC Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology
GA CH9ZH
UT WOS:000354394700002
PM 25157251
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Karahashi, M
   Ishii, F
   Yamazaki, T
   Imai, K
   Mitsumoto, A
   Kawashima, Y
   Kudo, N
AF Karahashi, Minako
   Ishii, Fumiko
   Yamazaki, Tohru
   Imai, Koichi
   Mitsumoto, Atsushi
   Kawashima, Yoichi
   Kudo, Naomi
TI Up-Regulation of Stearoyl-CoA Desaturase 1 Increases Liver MUFA Content
   in Obese Zucker but Not Goto-Kakizaki Rats
SO LIPIDS
LA English
DT Article
DE Desaturase; Elongase; Oleic acid; Palmitoleic acid; Goto-Kakizaki rat;
   Obese Zucker (fa/fa) rat
ID ENDOPLASMIC-RETICULUM STRESS; FATTY-ACID ELONGASE; INSULIN-RESISTANCE;
   HEPATIC STEATOSIS; GK RAT; METABOLIC SYNDROME; CHAIN ELONGATION;
   ADIPOSE-TISSUE; SECRETION; GENES
AB The Goto-Kakizaki (GK) rat is an animal model for spontaneous-onset, non-obese type 2 diabetes. Despite abundant evidence about disorders in metabolism, little information is available about fatty acid metabolism in the liver of GK rats. This study aimed to investigate the characteristics of the fatty acid profile, particularly MUFA, and the mechanism underlying the alterations in fatty acid profiles in the liver of GK rats. The activities of enzymes that participate in the biosynthesis of MUFA, expressions of genes encoding these enzymes, and the fatty acid profile in the liver were compared with those of obese Zucker (fa/fa) (ZF) rats, which are obese and non-diabetic. Stearoyl-CoA desaturase (SCD) activity and SCD1 gene expression were considerably up-regulated in GK rats, and these levels were largely comparable to those in ZF rats. However, the proportions and contents of oleic acid and palmitoleic acid were very low considering the highly elevated activity of SCD in the liver of GK rats, when compared with ZF rats. Palmitoyl-CoA chain elongation (PCE) activity and fatty acid elongase (Elovl6) gene expression were markedly up-regulated in ZF rats, whereas PCE activity was up-regulated much less and Elovl6 gene expression was unchanged in GK rats. These results suggest the possibility that up-regulation of gene expression of Elovl6 along with SCD1 is indispensable to elevate the proportions and contents of oleic acid in the liver.
C1 [Karahashi, Minako; Ishii, Fumiko; Yamazaki, Tohru; Kawashima, Yoichi; Kudo, Naomi] Josai Univ, Fac Pharmaceut Sci, Sakado, Saitama 3500295, Japan.
   [Imai, Koichi] Saitama Prefectural Inst Publ Hlth, Sakura Ku, Saitama 3380824, Japan.
   [Mitsumoto, Atsushi] Josai Int Univ, Fac Pharmaceut Sci, Togane, Chiba 2838555, Japan.
C3 Josai University
RP Kudo, N (corresponding author), Josai Univ, Fac Pharmaceut Sci, 1-1 Keyakidai, Sakado, Saitama 3500295, Japan.
EM naokudo@josai.ac.jp
FU Ministry of Education, Culture, Sports, Science and Technology of Japan
FX This work was supported by a Grant-in-Aid for Scientific Research from
   the Ministry of Education, Culture, Sports, Science and Technology of
   Japan.
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NR 58
TC 19
Z9 19
U1 0
U2 10
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0024-4201
EI 1558-9307
J9 LIPIDS
JI Lipids
PD MAY
PY 2013
VL 48
IS 5
BP 457
EP 467
DI 10.1007/s11745-013-3786-2
PG 11
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA 135QV
UT WOS:000318304500004
PM 23539346
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Kim, J
   Hakim, F
   Kheirandish-Gozal, L
   Gozal, D
AF Kim, Jinkwan
   Hakim, Fahed
   Kheirandish-Gozal, Leila
   Gozal, David
TI Inflammatory pathways in children with insufficient or disordered sleep
SO RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
LA English
DT Review
DE Obstructive sleep apnea; Obesity; Insufficient sleep; Inflammation;
   Pediatrics
ID C-REACTIVE PROTEIN; NF-KAPPA-B; EXCESSIVE DAYTIME SLEEPINESS;
   TUMOR-NECROSIS-FACTOR; NUTRITION EXAMINATION SURVEY; AMBULATORY
   BLOOD-PRESSURE; TNF-ALPHA LEVELS; CARDIOVASCULAR-DISEASE; METABOLIC
   SYNDROME; OXIDATIVE STRESS
AB Sleep is not only an essential physiological function, but also serves important roles in promoting growth, maturation, and overall health of children and adolescents. There is increasing interest regarding the impact of sleep and its disorders on the regulation of inflammatory processes and end-organ morbidities, particularly in the context of metabolic and cardiovascular diseases (CVD) and their complications. Obstructive sleep apnea syndrome (OSAS) is an increasingly common health problem in children, and in the last decade, the emergence of increasing obesity rates has further led to remarkable increases in the prevalence of OSAS, along with more prominent neurocognitive, behavioral, cardiovascular and metabolic morbidities. Although the underlying mechanisms leading to OSAS-induced morbidities are likely multi-factorial, and remain to be fully elucidated, activation of inflammatory pathways by OSAS has emerged as an important pathophysiological component of the end-organ injury associated with this disorder. To this effect, it would appear that OSAS could be viewed as a chronic, low-grade inflammatory disorder. Furthermore, the concurrent presence of obesity and OSAS poses a theoretically increased risk of OSAS-related complications. In this review, we will critically review the current state of research regarding the impact of insufficient and disrupted sleep and OSAS on the immune processes and inflammatory pathways that underlie childhood OSAS as a distinctive systemic inflammatory condition in children, and will explore potential interactions between OSAS and obesity. (C) 2011 Elsevier B.V. All rights reserved.
C1 [Kim, Jinkwan; Hakim, Fahed; Kheirandish-Gozal, Leila; Gozal, David] Univ Chicago, Dept Pediat, Comer Childrens Hosp, Chicago, IL 60637 USA.
C3 University of Chicago
RP Gozal, D (corresponding author), Univ Chicago, Dept Pediat, 5721 S Maryland Ave,MC 8000,Suite K-160, Chicago, IL 60637 USA.
EM dgozal@uchicago.edu
RI Kim, Jinyoung/LFS-2554-2024; Gozal, David/ABH-3805-2020
OI Gozal, Leila/0000-0003-3332-1057; Kim, Jinkwan/0000-0002-7123-1354
FU NIH [K12 HL-090003, HL-065270, HL-086662]; American Physician Fellowship
FX LKG is supported by NIH grant K12 HL-090003; DG is supported by National
   Institutes of Health grants HL-065270 and HL-086662; FH is supported by
   American Physician Fellowship.
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NR 204
TC 67
Z9 74
U1 0
U2 16
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1569-9048
EI 1878-1519
J9 RESP PHYSIOL NEUROBI
JI Respir. Physiol. Neuro.
PD SEP 30
PY 2011
VL 178
IS 3
SI SI
BP 465
EP 474
DI 10.1016/j.resp.2011.04.024
PG 10
WC Physiology; Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology; Respiratory System
GA 829GX
UT WOS:000295567700015
PM 21569868
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Ahmadie, R
   Santiago, JJ
   Walker, J
   Fang, TL
   Le, K
   Zhao, ZH
   Azordegan, N
   Bage, S
   Lytwyn, M
   Rattan, S
   Dixon, IMC
   Kardami, E
   Moghadasian, MH
   Jassal, DS
AF Ahmadie, Roien
   Santiago, Jon-Jon
   Walker, Jonathan
   Fang, Tielan
   Le, Khuong
   Zhao, Zhaohui
   Azordegan, Nazila
   Bage, Sheri
   Lytwyn, Matthew
   Rattan, Sunil
   Dixon, Ian M. C.
   Kardami, Elissavet
   Moghadasian, Mohammed H.
   Jassal, Davinder S.
TI A High-Lipid Diet Potentiates Left Ventricular Dysfunction in Nitric
   Oxide Synthase 3-Deficient Mice after Chronic Pressure Overload
SO JOURNAL OF NUTRITION
LA English
DT Article
ID FIBROBLAST GROWTH FACTOR-2; HIGH-MOLECULAR-WEIGHT; HEART-FAILURE;
   SMOOTH-MUSCLE; CARDIAC-HYPERTROPHY; METABOLIC SYNDROME; DEFICIENT MICE;
   KNOCKOUT MICE; RATS; RELAXATION
AB A high-lipid diet (HLD) may lead to adverse left ventricular (LV) remodeling and endothelial dysfunction in conditions of hemodynamic stress. Although congenital absence of nitric oxide synthase 3 (NOS3) leads to adverse LV remodeling after transverse aortic constriction (TAC), the effects of a HLD in this state remains unknown. Wild-type (WT) and NOS3 knockout mice (NOS3(-/-)) were randomized into the following 4 groups: 1) WT + low-lipid diet (LLD) (10% of energy); 2) WT + HLD (60% of energy); 3) NOS3(-/-) + LLD; and 4) NOS3(-/-) + HLD for a total of 12 wk. After 1 wk of randomization, TAC was performed on all groups. Serial echocardiography revealed a decrease in LV ejection fraction (LVEF) in WT and NOS3(-/-) mice fed the HLD compared with those fed the LLD diet at 12 wk post-TAC. Mice fed the NOS3(-/-) + HLD diet had a lower LVEF compared with mice in the other 3 groups (P < 0.05). There was greater myocyte hypertrophy, interstitial fibrosis, and percentage change in plasma cholesterol concentrations in the NOS3(-/-) + HLD group 12 wk post-TAC compared with the other 3 groups. Although high molecular weight fibroblast growth factor-2, a marker of cardiac hypertrophy, was more upregulated in the NOS3(-/-) + HLD group than in the other groups, markers of the renin-angiotensin system did not differ among them. A HLD potentiates LV dysfunction in NOS3(-/-) mice in a chronic pressure overload state. J. Nutr. 140: 1438-1444, 2010.
C1 [Ahmadie, Roien; Santiago, Jon-Jon; Walker, Jonathan; Fang, Tielan; Lytwyn, Matthew; Rattan, Sunil; Dixon, Ian M. C.; Kardami, Elissavet; Jassal, Davinder S.] Univ Manitoba, St Boniface Gen Hosp, Inst Cardiovasc Sci, Winnipeg, MB R2H 2A6, Canada.
   [Le, Khuong; Zhao, Zhaohui; Azordegan, Nazila; Moghadasian, Mohammed H.] Univ Manitoba, St Boniface Gen Hosp, Dept Human Nutr Sci, Winnipeg, MB R2H 2A6, Canada.
   [Le, Khuong; Zhao, Zhaohui; Azordegan, Nazila; Moghadasian, Mohammed H.] Univ Manitoba, St Boniface Gen Hosp, Canadian Ctr Agri Food Res Hlth & Med, St Boniface Res Ctr, Winnipeg, MB R2H 2A6, Canada.
   [Bage, Sheri] Univ Manitoba, St Boniface Gen Hosp, RO Burrell Lab, Winnipeg, MB R2H 2A6, Canada.
   [Jassal, Davinder S.] Univ Manitoba, St Boniface Gen Hosp, Cardiol Sect, Dept Cardiac Sci, Winnipeg, MB R2H 2A6, Canada.
   [Jassal, Davinder S.] Univ Manitoba, St Boniface Gen Hosp, Dept Radiol, Winnipeg, MB R2H 2A6, Canada.
C3 University of Manitoba; Saint Boniface Hospital; Children's Hospital
   Research Institute of Manitoba; University of Manitoba; Children's
   Hospital Research Institute of Manitoba; Saint Boniface Hospital;
   University of Manitoba; Saint Boniface Hospital; Children's Hospital
   Research Institute of Manitoba; University of Manitoba; Children's
   Hospital Research Institute of Manitoba; Saint Boniface Hospital;
   University of Manitoba; Children's Hospital Research Institute of
   Manitoba; Saint Boniface Hospital; University of Manitoba; Saint
   Boniface Hospital; Children's Hospital Research Institute of Manitoba
RP Jassal, DS (corresponding author), Univ Manitoba, St Boniface Gen Hosp, Inst Cardiovasc Sci, Winnipeg, MB R2H 2A6, Canada.
EM djassal@sbgh.mb.ca
RI ; Walker, Jonathan/O-4736-2017
OI Dixon, Ian/0000-0002-3763-5961; Jassal, Davinder S/0000-0002-3639-9047;
   Kardami, Elissavet/0000-0002-3198-8432; Walker,
   Jonathan/0000-0002-2995-0398; Rattan, Sunil/0000-0002-6022-0385
FU Manitoba Heart and Stroke Foundation; St. Boniface General Hospital and
   Research Foundation; Manitoba Health Research Council; Canadian
   Institute for Health Research; Manitoba Health and Research Council;
   NSERC; F.W. Du Val clinical research professorship; Heart and Stroke
   Foundation
FX Supported by grants from the Manitoba Heart and Stroke Foundation, St.
   Boniface General Hospital and Research Foundation, Manitoba Health
   Research Council, and the Canadian Institute for Health Research. R.A.
   and N.A. are recipients of the Manitoba Health and Research Council
   studentship award. J-J. S. is the recipient of a NSERC studentship. Z.Z.
   is the recipient of a postdoctoral fellowship from the Manitoba Health
   and Research Council. D.S.J. is the recipient of the F.W. Du Val
   clinical research professorship and Heart and Stroke Foundation New
   Investigator award.
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NR 35
TC 5
Z9 7
U1 0
U2 0
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0022-3166
EI 1541-6100
J9 J NUTR
JI J. Nutr.
PD AUG
PY 2010
VL 140
IS 8
BP 1438
EP 1444
DI 10.3945/jn.110.123091
PG 7
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 629PE
UT WOS:000280211300009
PM 20554900
OA Bronze
DA 2025-06-11
ER

PT J
AU Hartwich, J
   Leszczynska-Golabek, I
   Kiec-Wilk, B
   Siedlecka, D
   Perez-Martinez, P
   Marin, C
   Lopez-Miranda, J
   Tierney, A
   Mc Monagle, J
   Roche, HM
   Defoort, C
   Wolkow, P
   Dembinska-Kiec, A
AF Hartwich, Jadwiga
   Leszczynska-Golabek, Iwona
   Kiec-Wilk, Beata
   Siedlecka, Dominika
   Perez-Martinez, Pablo
   Marin, Carmen
   Lopez-Miranda, Jose
   Tierney, Audrey
   Mc Monagle, Jolene
   Roche, Helen M.
   Defoort, Catherine
   Wolkow, Pawel
   Dembinska-Kiec, Aldona
TI Lipoprotein profile, plasma Ischemia Modified Albumin and LDL density
   change in the course of postprandial lipemia. Insights from the LIPGENE
   study
SO SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION
LA English
DT Article
ID DIETARY FATTY-ACIDS; MYOCARDIAL-INFARCTION; INSULIN SENSITIVITY;
   OXIDATIVE STRESS; COBALT-BINDING; HEART-DISEASE; HEALTHY; TRIGLYCERIDE;
   MARKER; ASSOCIATION
AB Postprandial lipemia is associated with elevated risk of cardiovascular disease. Very little data exists regarding postprandial response in subjects with metabolic syndrome (MetS). The current study was conducted within the LIPGENE EU Integrated Project. Patients were randomized to one of the four isocaloric fatty meals (Oral Fat Tolerance Tests, OFTT): (A) high-fat, saturated fatty acid (SFA)-rich (HFSA), (B) high-fat, monounsaturated fatty acid (MUFA)-rich (HFMUFA), (C) low-fat, high-complex carbohydrate with 1.24 g high oleic sunflower oil supplement (LFHCC) and (D) low-fat high-complex carbohydrate with 1.24 g long chain n-3 poly-unsaturated fatty acid (LC n-3 PUFA) supplement (LFHCCn-3). The total and incremental areas under the curve (tAUC and iAUC) of plasma lipid and lipoprotein, Ischemia Modified Albumin (IMA) and LDL density were examined in patients with MetS to define effect of OFTT. All types of OFTT transiently increased plasma triglyceride and LDL density (LDLdens). It was paralleled by temporal decrease in total cholesterol (TC), LDL cholesterol (LDL-C), and HDL cholesterol (HDL-C). This last effect was partly alleviated in LFHCCn-3 test. A reversible increase of IMA was statistically significant only in the course of HSFA and HMUFA tests. EPA and DHA supplement in combined high complex-carbohydrate meal may attenuate adverse effect of tested meal on LDL particle profile and plasma ischemia modified albumin. No expected associations between measures of central adiposity (waist, WHR), adipose tissue insulin resistance (Adipo-IR), and postprandial responses of TG, TC, LDL-C, HDL-C, LDLdens and IMA/Alb ratio were found in subgroup analysis.
C1 [Hartwich, Jadwiga; Leszczynska-Golabek, Iwona; Kiec-Wilk, Beata; Siedlecka, Dominika; Dembinska-Kiec, Aldona] Jagiellonian Univ, Sch Med, Dept Clin Biochem, PL-30688 Krakow, Poland.
   [Perez-Martinez, Pablo; Marin, Carmen; Lopez-Miranda, Jose] Univ Cordoba, Sch Med, Reina Sofi Univ Hosp, Cordoba, Spain.
   [Tierney, Audrey; Mc Monagle, Jolene; Roche, Helen M.] Univ Coll Dublin, UCD Conway Inst, Nutrigen Res Grp, Dublin 2, Ireland.
   [Defoort, Catherine] INSERM, U476, F-13258 Marseille, France.
   [Wolkow, Pawel] Jagiellonian Univ, Sch Med, Dept Pharmacol, PL-30688 Krakow, Poland.
C3 Jagiellonian University; Universidad de Cordoba; University College
   Dublin; Institut National de la Sante et de la Recherche Medicale
   (Inserm); Jagiellonian University
RP Hartwich, J (corresponding author), Jagiellonian Univ, Sch Med, Fac Pharm, Dept Med Diagnost, Med 9, PL-30688 Krakow, Poland.
EM mbhartwi@cyf-kr.edu.pl
RI Roche, Helen/AAF-4164-2019; Lopez-Miranda, Jose/Y-8306-2019; Wolkow,
   Pawel/AAI-4222-2021; Tierney, Audrey/AAB-7068-2022; Marin Hinojosa,
   Carmen/AFO-1294-2022; Perez Martinez, Pablo/AEL-6176-2022
OI Roche, Helen/0000-0002-0628-3318; Perez Martinez,
   Pablo/0000-0001-7716-8117; Tierney, Audrey/0000-0001-8562-2877; Wolkow,
   Pawel/0000-0002-9322-5545
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NR 39
TC 13
Z9 14
U1 0
U2 11
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0036-5513
EI 1502-7686
J9 SCAND J CLIN LAB INV
JI Scand. J. Clin. Lab. Invest.
PD APR
PY 2010
VL 70
IS 3
BP 201
EP 208
DI 10.3109/00365511003663630
PG 8
WC Medical Laboratory Technology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology; Research & Experimental Medicine
GA 585HA
UT WOS:000276814500009
PM 20233037
DA 2025-06-11
ER

PT J
AU Cheung, O
   Puri, P
   Eicken, C
   Contos, MJ
   Mirshahi, F
   Maher, JW
   Kellum, JM
   Min, H
   Luketic, VA
   Sanyal, AJ
AF Cheung, Onpan
   Puri, Puneet
   Eicken, Christoph
   Contos, Melissa J.
   Mirshahi, Faridoddin
   Maher, James W.
   Kellum, John M.
   Min, Haeki
   Luketic, Velimir A.
   Sanyal, Arun J.
TI Nonalcoholic Steatohepatitis Is Associated with Altered Hepatic MicroRNA
   Expression
SO HEPATOLOGY
LA English
DT Article
ID FATTY LIVER-DISEASE; LIPID-METABOLISM; IN-VIVO; NORMALIZATION; ACID
AB The expression of microRNA in nonalcoholic steatohepatitis (NASH) and their role in the genesis of NASH are not known. The aims of this study were to: (1) identify differentially expressed microRNAs in human NASH, (2) tabulate their potential targets, and (3) define the effect of a specific differentially expressed microRNA, miR-122, on its targets and compare these effects with the pattern of expression of these targets in human NASH. The expression of 474 human microRNAs was compared in subjects with the metabolic syndrome and NASH versus controls with normal liver histology. Differentially expressed microRNAs were identified by the mu Paraflo microRNA microarray assay and validated using quantitative real-time polymerase chain reaction (PCR). The effects of a specific differentially expressed miRNA (miR-122) on its predicted targets were assessed by silencing and overexpressing miR-122 in vitro. A total of 23 microRNAs were underexpressed or overexpressed. The predicted targets of these microRNAs are known to affect cell proliferation, protein translation, apoptosis, inflammation, oxidative stress, and metabolism. The miR-122 level was significantly decreased in subjects with NASH (63% by real-time PCR, P < 0.00001). Silencing miR-122 led to an initial increase in mRNA levels of these targets (P < 0.05 for all) followed by a decrease by 48 hours. This was accompanied by an increase in protein levels of these targets (P < 0.05 for all). Overexpression of miR-122 led to a significant decrease in protein levels of these targets. Conclusions: NASH is associated with altered hepatic microRNA expression. Underexpression of miR-122 potentially contributes to altered lipid metabolism implicated in the pathogenesis of NASH. (HEPATOLOGY 2008;48: 1810-1820.)
C1 [Cheung, Onpan; Puri, Puneet; Mirshahi, Faridoddin; Min, Haeki; Luketic, Velimir A.; Sanyal, Arun J.] Virginia Commonwealth Univ, Med Ctr, Dept Internal Med, Div Gastroenterol Hepatol & Nutr, Richmond, VA USA.
   [Maher, James W.; Kellum, John M.] Virginia Commonwealth Univ, Med Ctr, Dept Surg, Richmond, VA USA.
   [Contos, Melissa J.] Virginia Commonwealth Univ, Med Ctr, Dept Pathol, Richmond, VA USA.
   [Eicken, Christoph] LC Sci, Houston, TX USA.
C3 Virginia Commonwealth University; Virginia Commonwealth University;
   Virginia Commonwealth University
RP Sanyal, AJ (corresponding author), MCV Box 980341, Richmond, VA 23298 USA.
EM asanyal@mcvh-vcu.edu
RI Kellum, John/LQK-0924-2024
FU National Institutes of Health [K 24 DK 02775-06, T-32 DK 02755-06, T-32
   DK 007150-32]; Virginia Commonwealth University Medical Center GCRC [MOI
   RR 00065-45]
FX Supported in part by two grants from the National Institutes of Health
   to Dr. Sanyal K 24 DK 02775-06 and T-32 DK 02755-06 and T-32 DK
   007150-32 as well as grant to Virginia Commonwealth University Medical
   Center GCRC (MOI RR 00065-45).
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NR 31
TC 552
Z9 607
U1 0
U2 45
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0270-9139
EI 1527-3350
J9 HEPATOLOGY
JI Hepatology
PD DEC
PY 2008
VL 48
IS 6
BP 1810
EP 1820
DI 10.1002/hep.22569
PG 11
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 376YP
UT WOS:000261219200011
PM 19030170
OA Bronze, Green Accepted
DA 2025-06-11
ER

PT J
AU Bozbas, H
   Yildirir, A
   Demir, O
   Cakmak, A
   Karacaglar, E
   Yilmaz, M
   Eroglu, S
   Pirat, B
   Ozin, B
   Muderrisoglu, H
AF Bozbas, Huseyin
   Yildirir, Aylin
   Demir, Ozlem
   Cakmak, Abdulkadir
   Karacaglar, Emir
   Yilmaz, Mustafa
   Eroglu, Serpil
   Pirat, Bahar
   Ozin, Bulent
   Muderrisoglu, Haldun
TI Serum gamma-glutamyltransferase activity is increased in patients with
   calcific aortic valve stenosis
SO JOURNAL OF HEART VALVE DISEASE
LA English
DT Article; Proceedings Paper
CT 29th Congress of the European-Society-of-Cardiology
CY SEP 01-05, 2007
CL Vienna, AUSTRIA
SP European Soc Cardiol
ID C-REACTIVE PROTEIN; METABOLIC SYNDROME; RISK; DISEASE; ASSOCIATION;
   LIPOPROTEIN; PROGRESSION; MORTALITY; ADULTS
AB Background and aim of the study: A growing body of data indicates an independent association between serum gamma-glutamyltransferase (GGT) activity, a marker of increased oxidative stress, and cardiovascular diseases. The process of calcific aortic valve disease has been shown to present characteristics of atherosclerosis. The study aim was to evaluate the possible role of serum GGT in patients with calcific aortic valve disease.
   Methods: The results of patients' echocardiography studies from 2005 for the presence of calcific aortic valve disease in the forms of aortic stenosis (AS) and aortic valve calcification (AVC) without significant valve stenosis, were retrospectively evaluated. Age and gender-matched patients with normal aortic valve morphology were selected at random as a control group. A total of 383 patients was enrolled into the study (126 with AS, 133 with AVC, 124 controls). Serum GGT activity, along with other liver enzyme analyses and laboratory results, were determined and compared among the groups.
   Results: Age, gender and clinical and laboratory results were similar among the three groups. Median serum GGT levels in the AS, AVC and control groups were 23.0 U/l (mean 31.5 +/- 24.9 U/l), 22.0 U/l (mean 27.6 +/- 18.6 U/) and 18.0 U/l (mean 22.4 +/- 16.4 U/l, respectively. Compared to controls, AS patients had significantly higher serum GGT and C-reactive protein levels, while the differences between AVC patients and controls for these parameters were not significant.
   Conclusion: The study results suggest that serum GGT activity is increased in patients with calcific AS. These increases seem to occur in advanced rather than milder forms of calcific aortic valve disease.
C1 [Bozbas, Huseyin; Yildirir, Aylin; Demir, Ozlem; Cakmak, Abdulkadir; Karacaglar, Emir; Yilmaz, Mustafa; Eroglu, Serpil; Pirat, Bahar; Ozin, Bulent; Muderrisoglu, Haldun] Baskent Univ, Fac Med, Dept Cardiol, TR-06490 Ankara, Turkey.
C3 Baskent University
RP Bozbas, H (corresponding author), Baskent Univ, Fac Med, Dept Cardiol, TR-06490 Ankara, Turkey.
EM hbozbas@gmail.com
RI Eroglu, Serpil/ABG-1582-2021; OZIN, Bulent/AAD-9938-2021; Pirat,
   Bahar/AAI-8897-2021; Yilmaz, Mustafa/S-6973-2016; Karacaglar,
   Emir/ABI-6723-2020; MUDERRISOGLU, IBRAHIM HALDUN/AAG-8233-2020;
   YILDIRIR, Aylin/A-4947-2018
OI Pirat, Bahar/0000-0003-4576-8630; Yilmaz, Mustafa/0000-0002-2557-9579;
   Karacaglar, Emir/0000-0002-2538-1642; Eroglu,
   Serpil/0000-0003-3055-7953; MUDERRISOGLU, IBRAHIM
   HALDUN/0000-0002-9635-6313; YILDIRIR, Aylin/0000-0001-8750-5287
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NR 21
TC 8
Z9 9
U1 0
U2 1
PU I C R PUBLISHERS
PI NORTHWOOD
PA CRISPIN HOUSE, 12/A SOUTH APPROACH, MOOR PARK, NORTHWOOD HA6 2ET,
   ENGLAND
SN 0966-8519
J9 J HEART VALVE DIS
JI J. Heart Valve Dis.
PD JUL
PY 2008
VL 17
IS 4
BP 371
EP 375
PG 5
WC Cardiac & Cardiovascular Systems
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 331LX
UT WOS:000258014800004
PM 18751465
DA 2025-06-11
ER

PT J
AU Amar, J
   Burcelin, R
   Ruidavets, JB
   Cani, PD
   Fauvel, J
   Alessi, MC
   Chamontin, B
   Ferriéres, J
AF Amar, Jacques
   Burcelin, Remy
   Ruidavets, Jean Bernard
   Cani, Patrice D.
   Fauvel, Josette
   Alessi, Marie Christine
   Chamontin, Bernard
   Ferrieres, Jean
TI Energy intake is associated with endotoxemia in apparently healthy men
SO AMERICAN JOURNAL OF CLINICAL NUTRITION
LA English
DT Article
ID DIET-INDUCED OBESITY; C-REACTIVE PROTEIN; INSULIN-RESISTANCE; METABOLIC
   SYNDROME; INFLAMMATION; ATHEROSCLEROSIS; PERMEABILITY; RECEPTOR; STRESS;
   ALPHA
AB Background: The bridge between food intake and weight is not fully understood. Recently, the role of gut microbiota and bacterial lipopolysacharides (LPS) in weight has been noted.
   Objective: The objective was to evaluate the relation between plasma LPS concentration and food intake.
   Design: A dietary survey was conducted in 1015 subjects randomly recruited in France. The participants were given oral and written instructions on how to keep a consecutive 3-d food record. Plasma LPS was measured in a subsample of 201 men. To assess, under controlled conditions, the differential impact of various high-energy diets, plasma LPS concentrations were measured in mice fed a high-fat or a high-carbohydrate diet over a 4-wk period.
   Results: In humans, no significant relation was observed between cardiovascular disease risk factors, carbohydrate and protein intakes, and plasma LPS concentration. Conversely, positive correlations were observed with fat and energy intakes. In a multivariate analysis, endotoxemia was independently associated with energy intake. Compared with the control mice, mice fed a high-energy diet showed an increase in plasma LPS. However, in mice fed a high-carbohydrate diet, the increase in plasma LPS was blunted compared with mice fed a high-fat diet.
   Conclusions: In this large sample of healthy men from a population-based sample, we found a link between food intake and plasma LPS. Experimental data suggest that fat was more efficient in transporting bacterial LPS from the gut lumen into the bloodstream. The results of this study add to the knowledge of mechanisms responsible for relations between food intake and metabolic diseases.
C1 [Amar, Jacques; Ruidavets, Jean Bernard; Chamontin, Bernard; Ferrieres, Jean] INSERM 558, Toulouse, France.
   [Burcelin, Remy; Cani, Patrice D.] IFR 31, I2MR, Inst Mol Med, Toulouse, France.
   [Fauvel, Josette] CHU Toulouse, INSERM, U 563, Serv Biochim, Toulouse, France.
   [Alessi, Marie Christine] INSERM, U 626, F-13258 Marseille, France.
C3 Institut National de la Sante et de la Recherche Medicale (Inserm);
   Universite de Toulouse; Universite Toulouse III - Paul Sabatier;
   Institut National de la Sante et de la Recherche Medicale (Inserm); CHU
   de Toulouse; Institut National de la Sante et de la Recherche Medicale
   (Inserm)
RP Amar, J (corresponding author), Hop Rangueil, Serv Med Interne Hypertens Arterielle, Allees Jean Pouilhes Toulouse, Toulouse, France.
EM amar.j@chu-toulouse.fr
RI burcelin, remy/M-6013-2014; Ferrieres, Jean/S-7993-2016; Cani, Patrice
   D./M-8055-2016; ALESSI, Marie-christine/AAK-3582-2020
OI Ferrieres, Jean/0000-0001-6144-1297; Cani, Patrice
   D./0000-0003-2040-2448; ALESSI, Marie-christine/0000-0003-3927-5792
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NR 31
TC 447
Z9 510
U1 0
U2 31
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0002-9165
EI 1938-3207
J9 AM J CLIN NUTR
JI Am. J. Clin. Nutr.
PD MAY
PY 2008
VL 87
IS 5
BP 1219
EP 1223
DI 10.1093/ajcn/87.5.1219
PG 5
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 301EZ
UT WOS:000255880500017
PM 18469242
OA Bronze
DA 2025-06-11
ER

PT J
AU Joshi-Barve, S
   Barve, SS
   Amancherla, K
   Gobejishvili, L
   Hill, D
   Cave, M
   Hote, P
   McClain, CJ
AF joshi-Barve, Swati
   Barve, Shirish S.
   Amancherla, Kiranmayi
   Gobejishvili, Leila
   Hill, Daniell
   Cave, Matthew
   Hote, Prachi
   McClain, Craig J.
TI Palmitic acid induces production of proinflammatory cytokine
   interleukin-8 from hepatocytes
SO HEPATOLOGY
LA English
DT Article
ID NF-KAPPA-B; TNF-ALPHA EXPRESSION; FATTY LIVER-DISEASE; NONALCOHOLIC
   STEATOHEPATITIS; APOPTOSIS; IL-8; TRANSCRIPTION; SIGNAL; CELLS; STYLE
AB Obesity and the metabolic syndrome are closely correlated with hepatic steatosis. Simple hepatic steatosis in nonalcoholic fatty liver disease can progress to nonalcoholic steatohepatitis (NASH), which can be a precursor to more serious liver diseases, such as cirrhosis and hepatocellular carcinoma. The pathogenic mechanisms underlying progression of steatosis to NASH remain unclear; however, inflammation, proinflammatory cytokines, and oxidative stress have been postulated to play key roles. We previously reported that patients with NASH have elevated serum levels of proinflammatory cytokines, such as interleukin-8 (IL-8), which are likely to contribute to hepatic injury. This study specifically examines the effect of hepatic steatosis on IL-8 production. We induced lipid accumulation in hepatocytes (HepG2, rat primary hepatocytes, and human primary hepatocytes) by exposing them to pathophysiologically relevant concentrations of palmitic acid to simulate the excessive influx of fatty acids into hepatocytes. Significant fat accumulation was documented morphologically by Oil Red 0 staining in cells exposed to palmitic acid, and it was accompanied by an increase in intracellular triglyceride levels. Importantly, palmitic acid was found to induce significantly elevated levels of biologically active neutrophil chemoattractant, IL-8, from steatotic hepatocytes. Incubation of the cells with palmitate led to increased IL-8 gene expression and secretion (both mRNA and protein) through mechanisms involving activation of nuclear factor kappaB (NF-kappa B) and c-Jun N-terminal kinase/activator protein-1. Conclusion: These data demonstrate for the first time that lipid accumulation in hepatocytes can stimulate IL-8 production, thereby potentially contributing to hepatic inflammation and consequent liver injury.
C1 Univ Louisville, Med Ctr, Dept Internal Med, Louisville, KY 40292 USA.
   Univ Louisville, Med Ctr, Dept Pharmacol & Toxicol, Louisville, KY 40292 USA.
C3 University of Louisville; University of Louisville
RP McClain, CJ (corresponding author), Univ Louisville, Med Ctr, Dept Internal Med, 550 S Jackson St,ACB 3rd Floor, Louisville, KY 40292 USA.
EM cjmccl01@kwise.louisville.edu
FU NIEHS NIH HHS [K01 ES017105] Funding Source: Medline
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NR 35
TC 323
Z9 362
U1 1
U2 54
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0270-9139
EI 1527-3350
J9 HEPATOLOGY
JI Hepatology
PD SEP
PY 2007
VL 46
IS 3
BP 823
EP 830
DI 10.1002/hep.21752
PG 8
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 206OA
UT WOS:000249191600027
PM 17680645
OA Bronze
DA 2025-06-11
ER

PT J
AU Debussche, X
   Roddier, M
   Fianu, A
   Le Moullec, N
   Papoz, L
   Favier, F
AF Debussche, X
   Roddier, M
   Fianu, A
   Le Moullec, N
   Papoz, L
   Favier, F
CA REDIA Study Grp
TI Health perceptions of diabetic patients in the REDIA study
SO DIABETES & METABOLISM
LA English
DT Article
DE diabetes; health perceptions; chronic diseases; knowledge; REDIA study
ID BEHAVIORAL-SCIENCE RESEARCH; REUNION-ISLAND; LIFE-STYLE; MELLITUS;
   EPIDEMIOLOGY; MANAGEMENT; PREVENTION; PREVALENCE; FRANCE; MODELS
AB Aim: To explore the beliefs and perceptions of type 2 diabetic patients in La Reunion where the disease is highly prevalent (17.5% among 30-69 yr old subjects) with a strong link to the metabolic syndrome and nutritional habits.
   Methods: Two sets of data were analysed. An 80-item questionnaire explored the perceptions of causal factors, knowledge of complications and therapeutic issues in 331 known diabetic patients included in the REDIA study. The data were completed by semi-structured interviews of 40 diabetic patients in a hospital setting.
   Results: Perceived causal factors of diabetes are mainly sugar excess, heredity and stress or life events. Weight excess and lack of physical activity are virtually never mentioned as causes. Diabetes is predominantly perceived as potentially acute, with risk of coma and death. Its chronic and progressive nature is not appreciated, and chronic complications are not well understood, especially in poorly educated people. Only 33% of males and 42% of females are willing to change their nutritional habits and the role of fats is largely underestimated (30.2%) although 90% consider physical activity as an effective course of action. Most patients are tardy in the way that they adopt medical recommendations and treatment in the course of the disease.
   Conclusion: These results highlight the discrepancy between medical knowledge and patients' perceptions, especially concerning etiological issues and complications. Lifestyle and therapeutic recommendations are not well understood. Educational activities need to consider the knowledge issues and understanding by patients early in the course of chronic diseases like diabetes.
C1 Ctr Hosp, Serv Diabetol Endocrinol, Dept Felix Guyon, F-97405 St Denis, Reunion, France.
   Grp Hosp Sud Reunion, URMLR, CHD GHSR, INSERM,CIC EC, St Pierre, Reunion, France.
   Grp Hosp Sud Reunion, Serv Endocrinol, St Pierre, Reunion, France.
   INSERM, REDIA Study Grp Coordinat, Montpellier, France.
   GHSR, St Pierre, Reunion, France.
   CHD, St Denis, Reunion, France.
C3 CHU Reunion; CHU Reunion; Institut National de la Sante et de la
   Recherche Medicale (Inserm); CHU Reunion; Institut National de la Sante
   et de la Recherche Medicale (Inserm); Universite de Montpellier; CHU
   Reunion; CHU Reunion
RP Ctr Hosp, Serv Diabetol Endocrinol, Dept Felix Guyon, F-97405 St Denis, Reunion, France.
EM x.debussche@wanadoo.fr
RI Debussche, Xavier/S-8185-2016; Favier, Francois/JJG-1337-2023
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NR 30
TC 16
Z9 16
U1 0
U2 2
PU MASSON EDITEUR
PI MOULINEAUX CEDEX 9
PA 21 STREET CAMILLE DESMOULINS, ISSY, 92789 MOULINEAUX CEDEX 9, FRANCE
SN 1262-3636
EI 1878-1780
J9 DIABETES METAB
JI Diabetes Metab.
PD FEB
PY 2006
VL 32
IS 1
BP 50
EP 55
DI 10.1016/S1262-3636(07)70246-X
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 018PF
UT WOS:000235776600006
PM 16523186
DA 2025-06-11
ER

PT J
AU Nozu, T
   Miyagishi, S
   Ishioh, M
   Takakusaki, K
   Okumura, T
AF Nozu, Tsukasa
   Miyagishi, Saori
   Ishioh, Masatomo
   Takakusaki, Kaoru
   Okumura, Toshikatsu
TI Irisin prevents visceral hypersensitivity and colonic hyperpermeability
   in a rat model of irritable bowel syndrome
SO PEPTIDES
LA English
DT Article
DE Irisin; Visceral pain; Gut barrier; Irritable bowel syndrome
ID CORTICOTROPIN-RELEASING-FACTOR; COLORECTAL DISTENSION;
   PHYSICAL-ACTIVITY; ACTIVATION; STRESS; EXPRESSION; PAIN
AB Visceral hypersensitivity and impaired gut barrier function, accompanied by minor inflammation, are crucial components of the pathophysiology of irritable bowel syndrome (IBS). Research has demonstrated that corticotropin-releasing factor (CRF) and toll-like receptor 4 (TLR4) signaling mutually activate to produce proinflammatory cytokines, which modulate these gastrointestinal changes. Irisin, a myokine, has been shown to inhibit TLR4-proinflammatory cytokine signaling, thereby improving inflammation driven by obesity and metabolic syndrome. Based on this, we hypothesized that irisin could improve visceral hypersensitivity and impaired gut barrier function induced by lipopolysaccharide (LPS) or CRF (IBS rat models), and tested this hypothesis. The visceral pain threshold, triggered by colonic balloon distention, was assessed by electrophysiologically monitoring abdominal muscle contractions in male Sprague-Dawley rats. Colonic permeability was evaluated by measuring the amount of Evans blue dye absorbed within the colonic tissue. Intraperitoneal irisin prevented LPS-induced visceral hypersensitivity and colonic hyperpermeability in a dose-dependent manner. Irisin also prevented CRF-induced gastrointestinal alterations. The beneficial effects of irisin in the LPS model were reversed by compound C, an AMP-activated protein kinase (AMPK) inhibitor; NG-nitro-L-arginine methyl ester, a nitric oxide (NO) synthesis inhibitor; sulpiride or domperidone, a dopamine D2 receptor antagonist; atropine and intracisternal injection of SB-334867, a selective orexin 1 receptor antagonist. Overall, these findings suggest that irisin improves visceral sensation and colonic barrier function through AMPK, NO and dopamine D2, cholinergic and brain orexin signaling in IBS model. Thus, irisin may be a promising therapeutic agent for treating IBS.
C1 [Nozu, Tsukasa] Asahikawa Med Univ, Dept Reg Med & Educ, 2-1-1-1 Midorigaoka Higashi, Asahikawa, Hokkaido 0788510, Japan.
   [Nozu, Tsukasa] Asahikawa Med Univ, Ctr Med Educ, 2-1-1-1 Midorigaoka Higashi, Asahikawa, Hokkaido 0788510, Japan.
   [Nozu, Tsukasa; Miyagishi, Saori; Ishioh, Masatomo; Okumura, Toshikatsu] Asahikawa Med Univ, Dept Gen Med, 2-1-1-1 Midorigaoka Higashi, Asahikawa, Hokkaido 0788510, Japan.
   [Takakusaki, Kaoru] Asahikawa Med Univ, Dept Physiol, Div Neurosci, 2-1-1-1 Midorigaoka Higashi, Asahikawa, Hokkaido 0788510, Japan.
C3 Asahikawa Medical College; Asahikawa Medical College; Asahikawa Medical
   College; Asahikawa Medical College
RP Nozu, T (corresponding author), Asahikawa Med Univ, Dept Reg Med & Educ, 2-1-1-1 Midorigaoka Higashi, Asahikawa, Hokkaido 0788510, Japan.
EM tnozu@sea.plala.or.jp; miyagishi@asahikawa-med.ac.jp;
   masatomo-ishioh@asahikawa-med.ac.jp; kusaki@asahikawa-med.ac.jp;
   okumurat@asahikawa-med.ac.jp
FU Akiyama Life Science Foundation [26120012]
FX This work was partially supported by the Japan Society for the Promotion
   of Science KAKENHI, Grant-in-Aid for Scientific Research (C) [22K08790
   (Tsukasa Nozu) and 26460955 (Toshikatsu Okumura)] ,Scientific Research
   on Innovative Areas [26120012 (Kaoru Takakusaki)] , and the research
   grant from the Akiyama Life Science Foundation (Tsukasa Nozu) .
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NR 68
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0196-9781
EI 1873-5169
J9 PEPTIDES
JI Peptides
PD JUN
PY 2025
VL 188
AR 171394
DI 10.1016/j.peptides.2025.171394
EA MAR 2025
PG 11
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism;
   Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism;
   Pharmacology & Pharmacy
GA 0XL1B
UT WOS:001458320400001
PM 40154794
DA 2025-06-11
ER

PT J
AU Khan, K
   Quazi, S
   Bankar, NJ
   Wanjari, A
   Gosavi, R
   Joshi, P
   Gupta, S
AF Khan, Khalid
   Quazi, Sabiha
   Bankar, Nandkishor J.
   Wanjari, Anil
   Gosavi, Rajesh
   Joshi, Prashant
   Gupta, Sunil
TI A Cross-Sectional Observational Study to Assess the Efficacy of
   Triglyceride to High-Density Lipoprotein Ratio as a Marker of Insulin
   Resistance in Subjects of Central Rural India
SO CUREUS JOURNAL OF MEDICAL SCIENCE
LA English
DT Article
DE triglyceride to high density lipoprotein ratio; obesity; one health;
   rural health; metabolic obesity; surrogate marker; central india;
   insulin resistance; tg/hdl ratio
ID GENDER-DIFFERENCES; METABOLIC SYNDROME; OBESITY; ASSOCIATIONS; SECRETION
AB Introduction: The rising prevalence of insulin resistance (IR), obesity, and its complications in India is due to lifestyle changes, eating patterns, stress, and genetic factors. Markers for IR are often expensive, invasive, or impractical for use in economically disadvantaged or remote areas. To address this, we evaluated the efficacy of the triglyceride to high -density lipoprotein (TG/HDL) ratio as a simple, reliable, accessible, and affordable surrogate marker of IR in comparison to the homeostatic model assessment for insulin resistance (HOMA-IR). Methods: This cross-sectional observational study was performed at a tertiary care center in central India and included 815 subjects aged 18 to 60 years after excluding those with systemic diseases, drugs affecting weight, or pregnant or lactating women. Descriptive and inferential statistical analysis was done to represent the study findings. Results: Males and obese subjects were more insulin resistant than females and non-obese subjects, respectively. The TG/HDL had a sensitivity of 91.81%, a specificity of 92.88%, a positive predictive value of 94.46%, and a negative predictive value of 89.56%, with a diagnostic accuracy of 92.27% when compared to HOMA-IR. Conclusion: We concluded that TG/HDL serves as a simple, affordable, and accurate marker of IR in a diverse population of central India. There is a definite scope to use the same for large-scale screening, epidemiological research, and routine clinical practice.
C1 [Khan, Khalid; Gosavi, Rajesh] Datta Meghe Inst Higher Educ & Res, Datta Meghe Med Coll, Med, Nagpur, India.
   [Quazi, Sabiha] Datta Meghe Inst Higher Educ & Res, Datta Meghe Med Coll, Dermatol, Nagpur, India.
   [Bankar, Nandkishor J.] Datta Meghe Inst Med Sci, Jawaharlal Nehru Med Coll, Microbiol, Wardha, India.
   [Wanjari, Anil] Datta Meghe Inst Med Sci, Jawaharlal Nehru Med Coll, Med, Wardha, India.
   [Joshi, Prashant] All India Inst Med Sci, Med, Nagpur, India.
   [Gupta, Sunil] Sunils Diabet Care N Res Ctr, Diabetol, Nagpur, India.
C3 Datta Meghe Institute of Higher Education & Research (Deemed to be
   University); Datta Meghe Medical College; Datta Meghe Institute of
   Higher Education & Research (Deemed to be University); Datta Meghe
   Medical College; Datta Meghe Institute of Higher Education & Research
   (Deemed to be University); Jawaharlal Nehru Medical College Wardha;
   Datta Meghe Institute of Higher Education & Research (Deemed to be
   University); Jawaharlal Nehru Medical College Wardha; All India
   Institute of Medical Sciences (AIIMS) Nagpur
RP Khan, K (corresponding author), Datta Meghe Inst Higher Educ & Res, Datta Meghe Med Coll, Med, Nagpur, India.
EM khalid.khan9t@gmail.com
RI Bankar, Nandkishor/ITU-8019-2023; Quazi, Sabiha/KIC-5890-2024; Khan,
   Khalid/ABB-1720-2020
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NR 47
TC 0
Z9 0
U1 0
U2 0
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
EI 2168-8184
J9 CUREUS J MED SCIENCE
JI Cureus J Med Sci
PD APR 19
PY 2024
VL 16
IS 4
AR e58612
DI 10.7759/cureus.58612
PG 14
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA QW1Y7
UT WOS:001223827200027
PM 38770513
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Van Mulders, L
   Locquet, L
   Kaandorp, C
   Janssens, GPJ
AF Van Mulders, Laurens
   Locquet, Laurent
   Kaandorp, Christine
   Janssens, Geert P. J.
TI An overview of nutritional factors in the aetiopathogenesis of
   myocardial fibrosis in great apes
SO NUTRITION RESEARCH REVIEWS
LA English
DT Review
DE carbohydrates; cardiovascular disease; fibre; great apes; hypertension;
   metabolic syndrome; myocardial fibrosis; nutrition; obesity; sodium;
   vitamin D
ID CHIMPANZEES PAN-TROGLODYTES; SYMPATHETIC-NERVOUS-SYSTEM;
   RENIN-ANGIOTENSIN SYSTEM; GORILLA-GORILLA-GORILLA; VITAMIN-D DEFICIENCY;
   GOMBE NATIONAL-PARK; BLOOD-PRESSURE; OXIDATIVE STRESS; HEART-FAILURE;
   CARDIAC-HYPERTROPHY
AB The main cause of mortality in great apes in zoological settings is cardiovascular disease (CVD), affecting all four taxa: chimpanzee (Pan troglodytes), bonobo (Pan paniscus), gorilla (Gorilla spp.) and orangutan (Pongo spp.). Myocardial fibrosis, the most typical histological characterisation of CVD in great apes, is non-specific, making it challenging to understand the aetiopathogenesis. A multifactorial origin of disease is assumed whereby many potential causative factors are directly or indirectly related to the diet, which in wild-living great apes mainly consists of high-fibre, low-carbohydrate and very low-sodium components. Diets of great apes housed in zoological settings are often different compared with the situation in the wild. Moreover, low circulating vitamin D levels have recently been recognised in great apes housed in more northern regions. Evaluation of current supplementation guidelines shows that, despite implementation of different dietary strategies, animals stay vitamin D insufficient. Therefore, recent hypotheses designate vitamin D deficiency as a potential underlying factor in the pathogenesis of myocardial fibrosis. The aim of this literature review is to: (i) examine important differences in nutritional factors between zoological and wild great ape populations; (ii) explain the potential detrimental effects of the highlighted dietary discrepancies on cardiovascular function in great apes; and (iii) elucidate specific nutrition-related pathophysiological mechanisms that may underlie the development of myocardial fibrosis. This information may contribute to understanding the aetiopathogenesis of myocardial fibrosis in great apes and pave the way for future clinical studies and a more preventive approach to great ape CVD management.
C1 [Van Mulders, Laurens; Janssens, Geert P. J.] Univ Ghent, Fac Vet Med, Merelbeke, Belgium.
   [Van Mulders, Laurens] Royal Zool Soc Antwerp KMDA, Antwerp, Belgium.
   [Locquet, Laurent] Univ Notingham, Dept Vet Med & Sci, Nottingham, England.
   [Locquet, Laurent] Dick White Referrals, Six Mile Bottom, Cambs, England.
   [Kaandorp, Christine] Safari Pk Beekse Bergen, Hilvarenbeek, Netherlands.
   [Kaandorp, Christine] Gaia Zoo, Kerkrade, Netherlands.
   [Kaandorp, Christine] Zooparc Overloon, Overloon, Netherlands.
   [Kaandorp, Christine] Dierenrijk, Mierlo, Netherlands.
C3 Ghent University; University of Nottingham
RP Van Mulders, L (corresponding author), Univ Ghent, Fac Vet Med, Merelbeke, Belgium.; Van Mulders, L (corresponding author), Royal Zool Soc Antwerp KMDA, Antwerp, Belgium.
EM laurens.vanmulders@ugent.be
RI Janssens, Geert/C-2264-2008
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NR 150
TC 0
Z9 0
U1 3
U2 9
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0954-4224
EI 1475-2700
J9 NUTR RES REV
JI Nutr. Res. Rev.
PD JUN
PY 2025
VL 38
IS 1
BP 37
EP 52
DI 10.1017/S0954422424000076
EA FEB 2024
PG 16
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 3DA2X
UT WOS:001192287700001
PM 38343129
OA hybrid
DA 2025-06-11
ER

PT J
AU Wu, DY
   Xiong, WY
   Ma, S
   Luo, JX
   Ye, HX
   Huang, SB
   Li, FY
   Xiang, XE
   Chen, QL
   Gao, BH
   Deng, JP
   Yin, YL
   Tan, CQ
AF Wu, Deyuan
   Xiong, Wenyu
   Ma, Shuo
   Luo, Jinxi
   Ye, Hongxuan
   Huang, Shuangbo
   Li, Fuyong
   Xiang, Xi'en
   Chen, Qiling
   Gao, Binghui
   Deng, Jinping
   Yin, Yulong
   Tan, Chengquan
TI Konjac flour-mediated gut microbiota alleviates insulin
   resistance and improves placental angiogenesis of obese sows
SO AMB EXPRESS
LA English
DT Article
DE Konjac flour; Fecal microbiota transplantation; SCFA; Insulin
   resistance; Placental angiogenesis
ID METABOLIC SYNDROME; SENSITIVITY; FAT; INCLUSION; STRESS; SHAPE
AB Our previous study revealed that dietary konjac flour (KF) could remodel gut microbiota and improve reproductive performance of sows, but its underlying mechanisms remain unclear. This experiment aimed to investigate how dietary KF improves reproductive performance of obese sows. Here, 60 sows were assigned into three groups according to their backfat thickness: normal backfat sows fed with control diet (CON-N), high backfat sows fed with control diet (CON-H) and high backfat sows fed with KF inclusion diet (KF-H). The characteristics of sows and piglets were recorded. Next, fecal microbiota transplantation (FMT) was performed on female mice, followed by recording the characteristics of female mice. The results showed that compared with CON-H group, KF-H group showed downtrend in stillbirth rate (P = 0.07), an increase in placental efficiency (P < 0.01) and average piglet weight (P < 0.01); coupled with a decrease in the values of homeostasis model assessment-insulin resistance (P < 0.01); as well as an increase in placental vascular density and protein expression of angiogenesis markers (P < 0.01). As expected, sows fed KF diets had improved abundance and diversity of gut microbiota. More importantly, compared with CON-H(FMT) group, KF-H(FMT) group showed improvement in reproductive performance and insulin sensitivity (P < 0.05), as well as an increase in placental labyrinth zone and protein expression of angiogenesis markers (P < 0.05). Furthermore, we found a content increase (P < 0.05) of SCFAs in both KF-H group sow and KF-H (FMT) group mice. Overall, KF supplementation could alleviate insulin resistance, promote placental angiogenesis, and ultimately improve the reproductive performance of sows via gut microbiota remodeling.
C1 [Wu, Deyuan; Xiong, Wenyu; Ma, Shuo; Luo, Jinxi; Ye, Hongxuan; Huang, Shuangbo; Li, Fuyong; Xiang, Xi'en; Chen, Qiling; Deng, Jinping; Yin, Yulong; Tan, Chengquan] South China Agr Univ, Natl Engn Res Ctr Breeding Swine Ind, Guangdong Prov Key Lab Anim Nutr Control, Inst Subtrop Anim Nutr & Feed,Coll Anim Sci, Guangzhou 510642, Guangdong, Peoples R China.
   [Gao, Binghui] Joinsha Anim Hlth Prod XIAMEN CO LTD, Xiamen 361000, Fujian, Peoples R China.
   [Yin, Yulong] Chinese Acad Sci, Inst Subtrop Agr, Natl Engn Lab Pollut Control & Waste Utilizat Live, Changsha 410125, Hunan, Peoples R China.
C3 South China Agricultural University; Chinese Academy of Sciences;
   Institute of Subtropical Agriculture, CAS
RP Yin, YL; Tan, CQ (corresponding author), South China Agr Univ, Natl Engn Res Ctr Breeding Swine Ind, Guangdong Prov Key Lab Anim Nutr Control, Inst Subtrop Anim Nutr & Feed,Coll Anim Sci, Guangzhou 510642, Guangdong, Peoples R China.; Yin, YL (corresponding author), Chinese Acad Sci, Inst Subtrop Agr, Natl Engn Lab Pollut Control & Waste Utilizat Live, Changsha 410125, Hunan, Peoples R China.
EM yinyulong@isa.ac.cn; tanchengquan@scau.edu.cn
FU Natural science foundation of guangdong province
FX Not applicable.
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NR 47
TC 2
Z9 2
U1 2
U2 14
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 2191-0855
J9 AMB EXPRESS
JI AMB Express
PD DEC 12
PY 2023
VL 13
IS 1
AR 143
DI 10.1186/s13568-023-01646-4
PG 12
WC Biotechnology & Applied Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology
GA CJ7T8
UT WOS:001124957900001
PM 38087159
OA gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Maiya, M
   Adorno, A
   Toulabi, SB
   Tucker, WJ
   Patterson, MA
AF Maiya, Madhura
   Adorno, Andrew
   Toulabi, Sahar B.
   Tucker, Wesley J.
   Patterson, Mindy A.
TI Resistant starch improves cardiometabolic disease outcomes: A narrative
   review of randomized trials
SO NUTRITION RESEARCH
LA English
DT Review
DE Fiber; Diabetes; Cardiovascular disease; Insulin resistance;
   Hypertension; Dyslipidemia; Abdominal obesity; Inflammation
ID INSULIN-RESISTANCE; METABOLIC SYNDROME; PHYSICAL-ACTIVITY; OXIDATIVE
   STRESS; GUT MICROBIOME; DIETARY FIBER; HEALTH; METAANALYSIS; NUTRITION;
   MORTALITY
AB Healthy dietary patterns with adequate fiber improve cardiometabolic (CM) outcomes and attenuate disease progression. Resistant starch (RS) is a fermentable fiber that affects CM outcomes; however, studies are heterogeneous and inconsistent. Thus, the purpose of this narrative review is to assess the impact of RS intake by type and amount on CM out-comes while considering subject characteristics and trial duration. Randomized crossover or parallel studies (n = 31) were selected and compared according to acute (1 day; n = 12), medium ( > 1-30 days; n = 8), or long ( > 30 days; n = 11) duration. Most acute trials in healthy adults showed improvements in postprandial glycemic outcomes irrespective of RS type or amount. However, a more pronounced reduction occurred when test meals did not match for available carbohydrate. Daily RS intake had a minimal effect on CM outcomes in medium duration trials, but insulin resistant adults had better glycemic control at 4 weeks. Several longer duration trials (8-12 weeks) showed favorable CM outcomes with daily RS intake in adults with type 2 diabetes (T2D), but not in those at risk for T2D. Furthermore, some studies reported improved lipids, inflammatory biomarkers, and heart rate. Future studies should consider matching for available carbohydrates between the RS and control groups to un-derstand the gut microbiome ' s role. Furthermore, energy and fiber should be considered. Overall, the acute intake of RS improves glycemic outcomes, and consuming RS at for least 4 and up to 8 to 12 weeks in adults with prediabetes and T2D, respectively, appears to im-prove CM outcomes.
C1 [Maiya, Madhura] Univ Texas Tyler, Dept Hlth & Kinesiol, Tyler, TX USA.
   [Adorno, Andrew; Tucker, Wesley J.; Patterson, Mindy A.] Texas Womans Univ, Inst Hlth Sci, Dept Nutr & Food Sci, Houston, TX USA.
   [Toulabi, Sahar B.] Colorado State Univ, Coll Agr Sci, Ft Collins, CO USA.
   [Tucker, Wesley J.; Patterson, Mindy A.] Texas Womans Univ, Inst Womens Hlth, Houston, TX USA.
   [Patterson, Mindy A.] Texas Womans Univ, Inst Hlth Sci, Dept Nutr & Food Sci, 6700 Fannin St, Houston, TX 77030 USA.
C3 University of Texas System; University of Texas at Tyler; Texas Womans
   University; Colorado State University System; Colorado State University
   Fort Collins; Texas Womans University; Texas Womans University
RP Patterson, MA (corresponding author), Texas Womans Univ, Inst Hlth Sci, Dept Nutr & Food Sci, 6700 Fannin St, Houston, TX 77030 USA.
EM mpatterson14@twu.edu
RI Maiya, Madhura/JQW-4324-2023; Patterson, Mindy/GLR-5656-2022
OI Maiya, Madhura/0000-0002-4620-133X; Patterson, Mindy/0000-0003-1391-4656
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NR 81
TC 5
Z9 5
U1 3
U2 13
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0271-5317
EI 1879-0739
J9 NUTR RES
JI Nutr. Res.
PD JUN
PY 2023
VL 114
BP 20
EP 40
DI 10.1016/j.nutres.2023.04.001
EA MAY 2023
PG 21
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA Q3AN8
UT WOS:001056275500001
PM 37149926
DA 2025-06-11
ER

PT J
AU Peng, J
   Yin, L
   Wang, K
   Zhang, TR
   Liu, HX
   Yang, JX
   Luo, J
AF Peng, Jie
   Yin, Lian
   Wang, Kun
   Zhang, Tingran
   Liu, Hengxu
   Yang, Jinxin
   Luo, Jiong
TI A Study on the Relationship Between Adolescent Health Behavior, BMI, and
   Blood Physical and Chemical Properties
SO FRONTIERS IN PUBLIC HEALTH
LA English
DT Article
DE health behavior; body mass index; blood biochemical indexes; health
   promotion; adolescents; correlation analysis
ID METABOLIC SYNDROME; CHILDHOOD OBESITY; OVERWEIGHT; PREVALENCE; CHILDREN;
   GIRLS; LIFE
AB In this study, the blood test index, demographic data, and health promotion behavior of adolescents were analyzed to provide a reference for early prevention and treatment of physical decline and abnormal biochemical indexes of adolescents. Using a cross-sectional study design, 1,436 valid samples were obtained by stratified random sampling, and the data were processed by SPSS21.0 statistical analysis software. The results showed that the overall health-promoting lifestyle of adolescents was good, and the interpersonal support behavior was the best, and the health responsibility and sports participation behavior were the worst; the interpersonal support and sports participation behavior of adolescents with normal weight were significantly better than those with overweight or light weight, while the overall health-promoting behavior of adolescents with high fasting blood glucose (FBG) before meals was poor, those with high glutamate pyruvate transaminase (GPT) had poor nutritional behavior and health responsibility behavior, while those with high uric acid (UA) had poor interpersonal support and stress coping behavior. The overweight rate and abnormal detection rate of UA and triglyceride (TG) in boys were significantly higher than those in girls, and the higher BMI of teenagers, the higher abnormal detection rate of GPT, UA, and TG, the better nutritional behavior, health responsibility behavior, and sports participation behavior, the lower abnormal detection rate of GPT, UA, and TG; the higher education level of parents, the better teenagers' sports participation and health responsibility behavior, the lower the incidence of overweight, the more time they spend playing online games and drinking sugary drinks on weekdays (or holidays), the higher the incidence of overweight.
C1 [Peng, Jie] Liupanshui Normal Univ, Sch Phys Educ, Liupanshui, Peoples R China.
   [Yin, Lian; Wang, Kun; Zhang, Tingran; Liu, Hengxu; Yang, Jinxin; Luo, Jiong] Southwest Univ, Coll Phys Educ, Res Ctr Exercise Detoxificat, Chongqing, Peoples R China.
C3 Liupanshui Normal University; Southwest University - China
RP Luo, J (corresponding author), Southwest Univ, Coll Phys Educ, Res Ctr Exercise Detoxificat, Chongqing, Peoples R China.
EM 784682301@qq.com
RI luo, jiong/MIN-6306-2025; Kun, Wang/KVA-4884-2024
FU humanities and social sciences of the Ministry of Education
   [20YJA890018]
FX & nbsp;This study was supported by the humanities and social sciences of
   the Ministry of Education (Grant No: 20YJA890018).
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NR 37
TC 2
Z9 3
U1 2
U2 21
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 2296-2565
J9 FRONT PUBLIC HEALTH
JI Front. Public Health
PD MAR 15
PY 2022
VL 10
AR 766101
DI 10.3389/fpubh.2022.766101
PG 8
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA 0H3MM
UT WOS:000778639800001
PM 35372227
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Hanawa, Y
   Higashiyama, M
   Kurihara, C
   Tanemoto, R
   Ito, S
   Mizoguchi, A
   Nishii, S
   Wada, A
   Inaba, K
   Sugihara, N
   Horiuchi, K
   Okada, Y
   Narimatsu, K
   Komoto, S
   Tomita, K
   Hokari, R
AF Hanawa, Yoshinori
   Higashiyama, Masaaki
   Kurihara, Chie
   Tanemoto, Rina
   Ito, Suguru
   Mizoguchi, Akinori
   Nishii, Shin
   Wada, Akinori
   Inaba, Kenichi
   Sugihara, Nao
   Horiuchi, Kazuki
   Okada, Yoshikiyo
   Narimatsu, Kazuyuki
   Komoto, Shunsuke
   Tomita, Kengo
   Hokari, Ryota
TI Acesulfame potassium induces dysbiosis and intestinal injury with
   enhanced lymphocyte migration to intestinal mucosa
SO JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
LA English
DT Article
DE acesulfame potassium; artificial sweetener; dysbiosis; intestinal
   inflammation; migration
ID GLUCAGON-LIKE PEPTIDE-2; ARTIFICIAL SWEETENERS; ENDOTHELIAL RECEPTOR;
   VASCULAR ADDRESSIN; CONSUMPTION; EXPRESSION; GLUCOSE; GLP-1; STRESS
AB Background and Aim The artificial sweetener acesulfame potassium (ACK) is officially approved as safe for intake and has been used in processed foods. However, ACKs have been reported to induce metabolic syndrome, along with alteration of the gut microbiota in mice. In recent years, studies have suggested that this artificial sweetener promotes myeloperoxidase reactivity in Crohn's disease-like ileitis. We aimed to investigate the effect of ACK on the intestinal mucosa and gut microbiota of normal mice. Methods Acesulfame potassium was administered to C57BL/6J mice (8 weeks old) via free drinking. Intestinal damage was evaluated histologically, and messenger RNA (mRNA) levels of TNF-alpha, IFN-gamma, IL1-beta, MAdCAM-1, GLP1R, and GLP2R were determined with quantitative reverse transcription polymerase chain reaction (qRT-PCR). Immunohistochemistry was performed to examine the expression of MAdCAM-1 in the small intestine. The composition of gut microbiota was assessed using high-throughput sequencing. We performed intravital microscopic observation to examine if ACK altered lymphocyte migration to the intestinal microvessels. Results Acesulfame potassium increased the expression of proinflammatory cytokines, decreased the expression of GLP-1R and GLP-2R, and induced small intestinal injury with an increase in intestinal permeability, and ACK treatment induced microbial changes, but the transfer of feces alone from ACK mice did not reproduce intestinal damage in recipient mice. ACK treatment significantly increased the migration of lymphocytes to intestinal microvessels. Conclusion Acesulfame potassium induces dysbiosis and intestinal injury with enhanced lymphocyte migration to intestinal mucosa. Massive use of non-caloric artificial sweeteners may not be as safe as we think.
C1 [Hanawa, Yoshinori; Higashiyama, Masaaki; Kurihara, Chie; Tanemoto, Rina; Ito, Suguru; Mizoguchi, Akinori; Nishii, Shin; Wada, Akinori; Inaba, Kenichi; Sugihara, Nao; Horiuchi, Kazuki; Okada, Yoshikiyo; Narimatsu, Kazuyuki; Komoto, Shunsuke; Tomita, Kengo; Hokari, Ryota] Natl Def Med Coll, Dept Internal Med, 3-2 Namiki, Tokorozawa, Saitama 3598513, Japan.
C3 National Defense Medical College - Japan
RP Hanawa, Y; Hokari, R (corresponding author), Natl Def Med Coll, Dept Internal Med, 3-2 Namiki, Tokorozawa, Saitama 3598513, Japan.
EM yoshio1769@yahoo.co.jp; ryota@ndmc.ac.jp
OI Higashiyama, Masaaki/0000-0002-3206-4055
FU Ministry of Health, Labour and Welfare, Japan
FX This research was supported by a Health and Labour Sciences research
   grant for research on intractable diseases, from the Ministry of Health,
   Labour and Welfare, Japan.
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NR 40
TC 22
Z9 23
U1 4
U2 23
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0815-9319
EI 1440-1746
J9 J GASTROEN HEPATOL
JI J. Gastroenterol. Hepatol.
PD NOV
PY 2021
VL 36
IS 11
BP 3140
EP 3148
DI 10.1111/jgh.15654
EA AUG 2021
PG 9
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA WT5RW
UT WOS:000686954200001
PM 34368996
DA 2025-06-11
ER

PT J
AU Hashemi, MS
   Namiranian, N
   Tavahen, H
   Dehghanpour, A
   Rad, MH
   Jam-Ashkezari, S
   Emtiazy, M
   Hashempur, MH
AF Hashemi, Monire Seyed
   Namiranian, Nasim
   Tavahen, Hemaseh
   Dehghanpour, Abolfazl
   Rad, Mohammad Hadi
   Jam-Ashkezari, Saeedeh
   Emtiazy, Majid
   Hashempur, Mohammad Hashem
TI Efficacy of Pomegranate Seed Powder on Glucose and Lipid Metabolism in
   Patients with Type 2 Diabetes: A Prospective Randomized Double-Blind
   Placebo-Controlled Clinical Trial
SO COMPLEMENTARY MEDICINE RESEARCH
LA English
DT Article
DE Type 2 diabetes mellitus; Pomegranate seed; Punica granatum; Glycemic
   indices; Triglyceride; Cholesterol; Traditional Persian medicine;
   Complementary medicine
ID PUNICA-GRANATUM POMEGRANATE; ANTIOXIDANT ACTIVITY; INSULIN-RESISTANCE;
   OXIDATIVE STRESS; HIGH-FAT; OIL; EXTRACT; INFLAMMATION; CONSUMPTION;
   CHILDREN
AB Introduction: Pomegranate is known as a functional food which has multiple health-promoting activities. It has been assessed for patients with metabolic syndrome. Specifically, an antidiabetic activity of its juice and plausible mechanisms for its action have been shown in multitudinous studies. The aim of this study was assessing the effects of complementary treatment with pomegranate seed powder (PSP) oral supplementation on patients with type 2 diabetes mellitus (T2DM). Methods: Sixty patients were treated for 8 weeks by 5 g PSP or placebo, twice daily. Fasting blood glucose (FBG), glycated hemoglobin (HbA(1c)), total cholesterol, and triglyceride (TG) were recorded as the outcome measures at the beginning and after the intervention. The findings were analyzed using the independent t test and Mann-Whitney U test. Results: After 8 weeks, the mean differences of FBG, HbA(1c), cholesterol, and TG were significantly decreased in the PSP group when compared with the placebo group (p value <0.05). In addition, post-intervention values of FBG and HbA(1c) were significantly lower in patients treated with PSP compared to the placebo group (p values = 0.02 and 0.01, respectively). However, the latter comparison regarding cholesterol and TG showed no significant differences (p values = 0.51 and 0.26, respectively). Conclusion: It seems that complementary treatment with PSP may have beneficial effects on FBG and HbA(1c) of patients with T2DM. However, its effect on TG and cholesterol was equivocal.
C1 [Hashemi, Monire Seyed; Tavahen, Hemaseh; Dehghanpour, Abolfazl; Emtiazy, Majid] Shahid Sadoughi Univ Med Sci, Sch Persian Med, Dept Persian Med, Yazd, Iran.
   [Namiranian, Nasim; Jam-Ashkezari, Saeedeh] Shahid Sadoughi Univ Med Sci, Yazd Diabet Res Ctr, Yazd, Iran.
   [Rad, Mohammad Hadi] Agr Res Educ & Extens Org AREEO, Agr & Nat Resource Res & Educ Ctr, Yazd, Iran.
   [Emtiazy, Majid] Shahid Sadoughi Univ Med Sci, Res Ctr Persian Med, Cent Bldg,Shahid Sadoughi St,POB 8951737915, Yazd, Iran.
   [Hashempur, Mohammad Hashem] Fasa Univ Med Sci, Noncommunicable Dis Res Ctr, Ibn E Sina Sq,POB 71348-14336, Fasa, Iran.
   [Hashempur, Mohammad Hashem] Fasa Univ Med Sci, Dept Persian Med, Fasa, Iran.
C3 Shahid Sadoughi University of Medical Sciences; Shahid Sadoughi
   University of Medical Sciences; Shahid Sadoughi University of Medical
   Sciences
RP Emtiazy, M (corresponding author), Shahid Sadoughi Univ Med Sci, Res Ctr Persian Med, Cent Bldg,Shahid Sadoughi St,POB 8951737915, Yazd, Iran.; Hashempur, MH (corresponding author), Fasa Univ Med Sci, Noncommunicable Dis Res Ctr, Ibn E Sina Sq,POB 71348-14336, Fasa, Iran.
EM research4tcam@gmail.com; hashempur@gmail.com
RI namiranian, nasim/AAR-1074-2021; emtiazy, majid/F-6625-2016; Hashempur,
   Mohammad/M-8736-2017
OI Hashempur, Mohammad Hashem/0000-0002-6700-9304
FU Yazd Shahid Sadoughi University of Medical Sciences
FX This study was financially supported by Yazd Shahid Sadoughi University
   of Medical Sciences. The funding organization had no role in study
   design, data collection and analysis, interpretation of data, and
   manuscript preparation.
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NR 61
TC 40
Z9 41
U1 2
U2 13
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 2504-2092
EI 2504-2106
J9 COMPLEMENT MED RES
JI Complement. Med. Res.
PD JUN
PY 2021
VL 28
IS 3
BP 226
EP 233
DI 10.1159/000510986
EA DEC 2020
PG 8
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA SU2JC
UT WOS:000599679500001
PM 33302270
OA Bronze
DA 2025-06-11
ER

PT J
AU Lugari, S
   Mantovani, A
   Nascimbeni, F
   Lonardo, A
AF Lugari, Simonetta
   Mantovani, Alessandro
   Nascimbeni, Fabio
   Lonardo, Amedeo
TI Hypothyroidism and nonalcoholic fatty liver disease - a chance
   association?
SO HORMONE MOLECULAR BIOLOGY AND CLINICAL INVESTIGATION
LA English
DT Review
DE epidemiology; HCC; NASH; physiopathology; TSH
ID HEPATIC TRIGLYCERIDE CONTENT; FREE THYROXINE LEVELS; SUBCLINICAL
   HYPOTHYROIDISM; THYROID-DYSFUNCTION; METABOLIC SYNDROME; RISK-FACTOR;
   HEPATOCELLULAR-CARCINOMA; OVERT HYPOTHYROIDISM; OXIDATIVE STRESS; OBESE
   CHILDREN
AB Background: Nonalcoholic fatty liver disease (NAFLD) defines the clinical-pathological spectrum of hepatic lipotoxicity, which may progress to hepatic fibrosis and its complications. Thyroid hormone is a master regulator of cell metabolism and body fat distribution. Whether hypothyroidism is associated or not with an increased risk of developing NAFLD and its fibrotic progression is both clinically and physiopathologically relevant. Indeed, answering this research question would carry major pathogenic and therapeutic implications.
   Method: PubMed database was searched using relevant key-words such as hypothyroidism; NAFLD; nonalcoholic steatohepatitis; cirrhosis; hepatocellular carcinoma; epidemiology; pathogenesis; natural history. The epidemiological studies and the meta-analyses published so far were identified as well as those studies addressing the physiopathology underlying this association.
   Results: Many observational studies have investigated the association between either subclinical or overt hypothyroidism and NAFLD. Data are conflicting: some original and meta-analytical studies demonstrated that hypothyroidism, (mainly subclinical hypothyroidism), was common, occurring in approximately 25% of individuals with imaging-defined or biopsy-proven NAFLD; other studies, however, failed to identify a significant association between hypothyroidism and NAFLD. Moreover, such an association is biologically plausible based on the specific physiopathological impact of thyroid hormone and thyroid stimulating hormone (TSH) on metabolism of hepatocytes and accumulation and distribution of body fat.
   Conclusions: The findings from the present review support a significant association between primary hypothyroidism and risk of development and progression of NAFLD. However, further studies evaluating the relative importance of subclinical versus overt hypothyroidism as well as addressing the mechanisms underlying the association of hypothyroidism with NAFLD are eagerly awaited.
C1 [Lugari, Simonetta; Nascimbeni, Fabio] Univ Modena & Reggio Emilia, Dept Biomed Metab & Neural Sci, Modena, Italy.
   [Mantovani, Alessandro] Univ Verona, Dept Med, Sect Endocrinol Diabet & Metab, Verona, Italy.
   [Mantovani, Alessandro] Azienda Osped Univ Integrata Verona, Verona, Italy.
   [Lonardo, Amedeo] Azienda Osped Univ, Osped Civile Baggiovara, Dept Biomed Metab & Neural Sci, Div Internal Med, Modena, Italy.
C3 Universita di Modena e Reggio Emilia; University of Verona; University
   of Verona; Azienda Ospedaliera Universitaria Integrata Verona;
   Universita di Modena e Reggio Emilia; Universita di Modena e Reggio
   Emilia Hospital
RP Lugari, S (corresponding author), Univ Modena & Reggio Emilia, Dept Biomed Metab & Neural Sci, Modena, Italy.
EM simonetta.lugari@libero.it
RI LONARDO, AMEDEO/I-5911-2019; Mantovani, Alessandro/AAB-9015-2019
OI Nascimbeni, Fabio/0000-0002-1051-1272; Mantovani,
   Alessandro/0000-0002-7271-6329
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NR 117
TC 18
Z9 18
U1 0
U2 6
PU WALTER DE GRUYTER GMBH
PI BERLIN
PA GENTHINER STRASSE 13, D-10785 BERLIN, GERMANY
SN 1868-1883
EI 1868-1891
J9 HORM MOL BIOL CLIN I
JI Horm. Mol. Biol. Clin. Investig.
PD MAR
PY 2020
VL 41
IS 1
SI SI
AR 20180047
DI 10.1515/hmbci-2018-0047
PG 14
WC Biochemistry & Molecular Biology
WE Emerging Sources Citation Index (ESCI)
SC Biochemistry & Molecular Biology
GA LG7KQ
UT WOS:000528275500004
PM 30367792
OA Green Published
DA 2025-06-11
ER

PT J
AU Lee, JH
   Baek, SY
   Jang, EJ
   Ku, SK
   Kim, KM
   Ki, SH
   Kim, CE
   Park, KI
   Kim, SC
   Kim, YW
AF Lee, Ju-Hee
   Baek, Su Youn
   Jang, Eun Jeong
   Ku, Sae Kwang
   Kim, Kyu Min
   Ki, Sung Hwan
   Kim, Chang-Eop
   Park, Kwang Il
   Kim, Sang Chan
   Kim, Young Woo
TI Oxyresveratrol ameliorates nonalcoholic fatty liver disease by
   regulating hepatic lipogenesis and fatty acid oxidation through liver
   kinase B1 and AMP-activated protein kinase
SO CHEMICO-BIOLOGICAL INTERACTIONS
LA English
DT Article
DE Oxyresveratrol; Nonalcoholic fatty liver disease; AMPK; SREBP-1c
ID METABOLIC SYNDROME; INSULIN-RESISTANCE; X-RECEPTOR; LIPID-METABOLISM;
   MORUS-ALBA; MICE; RESVERATROL; DIET; CHOLESTEROL; POLYPHENOLS
AB Oxyresveratrol (OXY) is a naturally occurring polyhydroxylated stilbene that is abundant in mulberry wood (Morus alba L.), which has frequently been supplied as a herbal medicine. It has been shown that OXY has regulatory effects on inflammation and oxidative stress, and may have potential in preventing or curing nonalcoholic fatty liver disease (NAFLD). This study examined the effects of OXY on in vitro model of NAFLD in hepatocyte by the liver X receptor alpha (LXR alpha)-mediated induction of lipogenic genes and in vivo model in mice along with its molecular mechanism. OXY inhibited the LXR alpha agonists-mediated sterol regulatory element binding protein-1c (SREBP-1c) induction and expression of the lipogenic genes and upregulated the mRNA of fatty acid beta-oxidation-related genes in hepatocytes, which is more potent than genistein and daidzein. OXY also induced AMP-activated protein kinase (AMPK) activation in a time-dependent manner. Moreover, AMPK activation by the OXY treatment helped inhibit SREBP-1c using compound C as an AMPK antagonist. Oral administration of OXY decreased the Oil Red O stained-positive areas significantly, indicating lipid droplets and hepatic steatosis regions, as well as the serum parameters, such as fasting glucose, total cholesterol, and low density lipoprotein-cholesterol in high fat diet fed-mice, as similar with orally treatment of atorvastatin. Overall, this result suggests that OXY has the potency to inhibit hepatic lipogenesis through the AMPK/SREBP-1c pathway and can be used in the development of pharmaceuticals to prevent a fatty liver.
C1 [Lee, Ju-Hee; Baek, Su Youn; Jang, Eun Jeong; Ku, Sae Kwang; Kim, Sang Chan; Kim, Young Woo] Daegu Haany Univ, Coll Oriental Med, Gyongsan 38610, South Korea.
   [Lee, Ju-Hee] Dongguk Univ, Coll Korean Med, Gyeongju 38066, South Korea.
   [Kim, Kyu Min; Ki, Sung Hwan] Chosun Univ, Coll Pharm, Gwangju 61452, South Korea.
   [Kim, Chang-Eop] Gachon Univ, Coll Oriental Med, Seongnam 13120, Gyeonggido, South Korea.
   [Park, Kwang Il] Korea Inst Oriental Med, Daegeon 34054, South Korea.
C3 Daegu Haany University; Dongguk University; Chosun University; Gachon
   University; Korea Institute of Oriental Medicine (KIOM)
RP Kim, YW (corresponding author), Daegu Haany Univ, Coll Oriental Med, Gyongsan 38610, South Korea.
EM ywkim@dhu.ac.kr
RI kim, kyumin/KDN-4319-2024; Lee, Sang Jin/S-4056-2019; Kim, Sang
   Chan/IUQ-5763-2023
OI Lee, Ju-Hee/0000-0003-4147-9794
FU National Research Foundation of Korea (NRF) grant - Korea Government
   [MSIP] [2015K1A3A1A59069800]; Korea Ministry of Education, Science and
   Technology (MEST) [K18102]
FX This work was supported by the National Research Foundation of Korea
   (NRF) grant funded by the Korea Government [MSIP] (No.
   2015K1A3A1A59069800) and also by the Grant K18102 awarded to Korea
   Institute of Oriental Medicine (KIOM) from Korea Ministry of Education,
   Science and Technology (MEST).
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NR 43
TC 43
Z9 45
U1 2
U2 52
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0009-2797
EI 1872-7786
J9 CHEM-BIOL INTERACT
JI Chem.-Biol. Interact.
PD JUN 1
PY 2018
VL 289
BP 68
EP 74
DI 10.1016/j.cbi.2018.04.023
PG 7
WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology
GA GG3EW
UT WOS:000432576000009
PM 29702089
DA 2025-06-11
ER

PT J
AU Luke, B
AF Luke, Barbara
TI Adverse effects of female obesity and interaction with race on
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SO FERTILITY AND STERILITY
LA English
DT Review
DE Obesity; prenatal growth restriction; abnormal glycemic parameters;
   insulin resistance; metabolic environment
ID BODY-MASS INDEX; IN-VITRO FERTILIZATION; C-REACTIVE PROTEIN; MATERNAL
   OBESITY; BIRTH-WEIGHT; PREPREGNANCY OBESITY; ASSISTED CONCEPTION;
   PREGNANCY OUTCOMES; INSULIN-RESISTANCE; METABOLIC SYNDROME
AB Across the reproductive spectrum, obesity is associated with greater risks for adverse health outcomes, including higher rates of infertility, subfertility, early pregnancy loss, fetal deaths and stillbirths, congenital anomalies, and pregnancy complications. The excess reproductive morbidity associated with obesity may increase with longer duration, making the current trends among children and young adults particularly critical in terms of their future reproductive potential. Obese women have a lower chance of pregnancy following in vitro fertilization (IVF), require higher dosages of gonadotropins, and have reduced rates of implantation, clinical intrauterine gestation, and live birth rates and increased rates of pregnancy loss, as well as greater risks for prematurity and preeclampsia even when stratified by plurality. Racial and ethnic differences by overweight and obesity in IVF outcomes have been reported. Compared with normal-weight women, failure to achieve a clinical intrauterine gestation is significantly more likely among obese women overall, normal-weight and obese Asian women, normal-weight Hispanic women, and overweight and obese Black women. Among women who do conceive, compared with normal-weight women, failure to achieve a live birth is significantly more likely among overweight and obese women overall, and among overweight and obese Asian women, overweight and obese Hispanic women, and normal-weight and obese Black women. Although weight loss should theoretically be the first line of therapy for obese women, other lifestyle factors, such as regular physical exercise, elimination of tobacco use and alcohol consumption, and stress management, may be of more immediate benefit in achieving conception. (C) 2017 by American Society for Reproductive Medicine.
C1 [Luke, Barbara] Michigan State Univ, Coll Human Med, Dept Obstet Gynecol & Reprod Biol, B227 West Fee Hall, E Lansing, MI 48824 USA.
C3 Michigan State University; Michigan State University College of Human
   Medicine
RP Luke, B (corresponding author), Michigan State Univ, Coll Human Med, Dept Obstet Gynecol & Reprod Biol, B227 West Fee Hall, E Lansing, MI 48824 USA.
EM lukeb@msu.edu
FU NICHD NIH HHS [R01 HD084377] Funding Source: Medline
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NR 118
TC 44
Z9 47
U1 0
U2 27
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0015-0282
EI 1556-5653
J9 FERTIL STERIL
JI Fertil. Steril.
PD APR
PY 2017
VL 107
IS 4
DI 10.1016/j.fertnstert.2017.02.114
PG 10
WC Obstetrics & Gynecology; Reproductive Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology; Reproductive Biology
GA ET7FH
UT WOS:000400459100008
PM 28366413
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Fan, L
   Feng, Y
   Chen, GC
   Qin, LQ
   Fu, CL
   Chen, LH
AF Fan, Li
   Feng, Yu
   Chen, Guo-Chong
   Qin, Li-Qiang
   Fu, Chun-ling
   Chen, Li-Hua
TI Effects of coenzyme Q10 supplementation on inflammatory markers: A
   systematic review and meta-analysis of randomized controlled trials
SO PHARMACOLOGICAL RESEARCH
LA English
DT Review
DE Coenzyme Q10; Inflammation; C-reactive protein; lnterleukin-6; Tumor
   necrosis factor-alpha; Meta-analysis
ID C-REACTIVE PROTEIN; CORONARY-ARTERY-DISEASE; PLACEBO-CONTROLLED TRIAL;
   CHRONIC KIDNEY-DISEASE; CYTOKINES TNF-ALPHA; CLINICAL-TRIAL;
   DOUBLE-BLIND; METABOLIC SYNDROME; OXIDATIVE STRESS; HEART-FAILURE
AB The aims of this meta-analysis were to evaluate the effects of coenzyme Q10 (CoQ10) supplementation on inflammatory mediators including C-reactive protein (CRP), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) by analyzing published randomized controlled trials (RCTs). A systematic search in PubMed, Cochrane Library and Clinicaltrials.gov was performed to identify eligible RCTs. Data synthesis was performed using a random- or a fixed-effects model depending on the results of heterogeneity tests, and pooled data were displayed as weighed mean difference (WMD) and 95% confidence interval (CI). Seventeen RCTs were selected for the meta-analysis. CoQ10 supplementation significantly reduced the levels of circulating CRP (WMD: -0.35 mg/L, 95% CI: -0.64 to -0.05, P = 0.022), IL-6 (WMD: -1.61 pg/mL, 95% CI: -2.64 to -0.58, P = 0.002) and TNF-alpha (WMD: -0.49 pg/mL, 95% CI: -0.93 to -0.06, P = 0.027). The results of meta-regression showed that the changes of CRP were independent of baseline CRP, treatment duration, dosage, and patients characteristics. In the meta-regression analyses, a higher baseline IL-6 level was significantly associated with greater effects of CoQ10 on IL-6 levels (P for interaction = 0.006). In conclusion, this meta-analysis of RCTs suggests significant lowering effects of CoQ10 on CRP, IL-6 and TNF-alpha. However, results should be interpreted with caution because of the evidence of heterogeneity and limited number of studies. (C) 2017 Elsevier Ltd. All rights reserved.
C1 [Fan, Li; Feng, Yu; Chen, Guo-Chong; Qin, Li-Qiang; Fu, Chun-ling; Chen, Li-Hua] Soochow Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Jiangsu Key Lab Prevent & Translat Med Geriatr Di, 199 Renai Rd, Suzhou 215123, Peoples R China.
   [Feng, Yu] Soochow Univ, Affiliated Hosp 2, 1055 Sanxiang Rd, Suzhou 215004, Peoples R China.
C3 Soochow University - China; Soochow University - China
RP Chen, LH (corresponding author), Soochow Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Jiangsu Key Lab Prevent & Translat Med Geriatr Di, 199 Renai Rd, Suzhou 215123, Peoples R China.
EM 20155247008@stu.suda.edu.cn; fy1677@yeah.net; lsguorong@126.com;
   qinliqiang@suda.edu.cn; fuchunling@suda.edu.cn; chenlihua@suda.edu.cn
RI Chen, Lihua/AAH-7898-2019; Chen, Guo-Chong/K-4046-2017; Feng,
   Yu/Q-6549-2016
OI Feng, Yu/0000-0003-0034-6397; Chen, Li-Hua/0000-0002-0839-3254
FU Natural Science Foundation of Jiangsu Province [BK20140372]
FX This work was supported by grants from Natural Science Foundation of
   Jiangsu Province (BK20140372).
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EP 136
DI 10.1016/j.phrs.2017.01.032
PG 9
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA EU7FV
UT WOS:000401201600012
PM 28179205
DA 2025-06-11
ER

PT J
AU Huo, WQ
   Xia, W
   Wan, YJ
   Zhang, B
   Zhou, AF
   Zhang, YM
   Huang, K
   Zhu, YS
   Wu, CS
   Peng, Y
   Jiang, MM
   Hu, J
   Chang, HL
   Xu, B
   Li, YY
   Xu, SQ
AF Huo, Wenqian
   Xia, Wei
   Wan, Yanjian
   Zhang, Bin
   Zhou, Aifen
   Zhang, Yiming
   Huang, Kai
   Zhu, Yingshuang
   Wu, Chuansha
   Peng, Yang
   Jiang, Minmin
   Hu, Jie
   Chang, Huailong
   Xu, Bing
   Li, Yuanyuan
   Xu, Shunqing
TI Maternal urinary bisphenol A levels and infant low birth weight: A
   nested case-control study of the Health Baby Cohort in China
SO ENVIRONMENT INTERNATIONAL
LA English
DT Article
DE Low birth weight; Bisphenol A; Case-control; Urine; Pregnancy
ID MEMBRANE ESTROGEN-RECEPTOR; PRENATAL EXPOSURE; PREGNANT-WOMEN;
   DEVELOPMENTAL TOXICITY; METABOLIC SYNDROME; OXIDATIVE STRESS;
   UNITED-STATES; IN-UTERO; GROWTH; PHENOLS
AB Background: Exposure to bisphenol A (BPA), a known endocrine disruptor, has been demonstrated to affect fetal development in animal studies, but findings in human studies have been inconsistent.
   Objectives: We investigated whether maternal exposure to BPA during pregnancy is associated with an increased risk of infant low birth weight (LBW).
   Methods: A total 452 mother-infant pairs (113 LBW cases and 339 matched controls) were selected from the participants enrolled in the prospective Health Baby Cohort (HBC) in Wuhan city, China, during 2012-2014. BPA concentrations were measured in maternal urine samples collected at delivery, and the information of birth outcomes was retrieved from the medical records. A conditional logistic regression was used to evaluate the relationship between urinary BPA levels and LBW.
   Results: Mothers with LBW infants had significantly higher urinary BPA levels (median: 4.70 mu g/L) than the control mothers (median: 2.25 mu g/L) (p < 0.05). Increased risk of LBW was associated with higher maternal urinary levels of BPA [adjusted odds ratio (OR) = 3.13 for the medium tertile, 95% confidence interval (CI): 121,8.08; adjusted OR = 2.49 for the highest tertile, 95% CI: 0.98, 636]. The association was more pronounced among female infants than among male infants, with a statistical evidence of heterogeneity in risk (p = 0.03).
   Conclusions: Prenatal exposure to higher levels of BPA may potentially increase the risk of delivering LBW infants, especially for female infants. This is the first case-control study to examine the association in China. (C) 2015 Elsevier Ltd. All rights reserved.
C1 [Huo, Wenqian; Xia, Wei; Huang, Kai; Zhu, Yingshuang; Wu, Chuansha; Peng, Yang; Jiang, Minmin; Hu, Jie; Chang, Huailong; Xu, Bing; Li, Yuanyuan; Xu, Shunqing] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Key Lab Environm & Hlth,Minist Educ, Wuhan 430030, Hubei, Peoples R China.
   [Huo, Wenqian; Xia, Wei; Huang, Kai; Zhu, Yingshuang; Wu, Chuansha; Peng, Yang; Jiang, Minmin; Hu, Jie; Chang, Huailong; Xu, Bing; Li, Yuanyuan; Xu, Shunqing] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, State Key Lab Environm Hlth,Minist Environm Prote, Wuhan 430030, Hubei, Peoples R China.
   [Wan, Yanjian] Gen Hosp Yangtze River Shipping, CDC Yangtze River Adm & Nav Affairs, Wuhan 430019, Peoples R China.
   [Zhang, Bin; Zhou, Aifen; Zhang, Yiming] Women & Children Med & Healthcare Ctr Wuhan, Wuhan, Hubei, Peoples R China.
C3 Huazhong University of Science & Technology; Ministry of Education -
   China; Huazhong University of Science & Technology
RP Li, YY (corresponding author), Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Wuhan 430030, Peoples R China.
EM liyuanyuan@hust.edu.cn; xust@hust.edu.cn
RI jiang, minmin/JXN-6056-2024; Peng, Yang/AAC-7707-2020; Wan,
   Yanjian/HNQ-3057-2023; huo, wenqian/O-1974-2013; Chang,
   Huailong/P-7888-2019; Ling, Jie/JJF-9995-2023; Li,
   Yuanyuan/GRS-1755-2022
OI Hu, Jie/0000-0001-8282-4895; Xu, Shunqing/0000-0002-7771-3821; Chang,
   Huailong/0000-0003-3994-6234; Li, Yuanyuan/0000-0003-4967-3890; Huo,
   Wenqian/0000-0002-7898-093X
FU National Basic Research Program of China (973 Program) [2012CB722401];
   National Natural Science Foundation of China [21437002, 81372959,
   81402649, 21177046]; R&D Special Fund for Public Welfare Industry
   (Environment) [201309048]; Doctoral Fund of Ministry of Education of
   China [20120142120017]
FX This work was supported by the National Basic Research Program of China
   (973 Program) (2012CB722401), the National Natural Science Foundation of
   China (21437002, 81372959, 81402649, 21177046), the R&D Special Fund for
   Public Welfare Industry (Environment) (201309048), and the Doctoral Fund
   of Ministry of Education of China (20120142120017).
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NR 68
TC 97
Z9 114
U1 4
U2 82
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0160-4120
EI 1873-6750
J9 ENVIRON INT
JI Environ. Int.
PD DEC
PY 2015
VL 85
BP 96
EP 103
DI 10.1016/j.envint.2015.09.005
PG 8
WC Environmental Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology
GA CX0CF
UT WOS:000365363800011
PM 26382648
DA 2025-06-11
ER

PT J
AU Jousse, C
   Muranishi, Y
   Parry, L
   Montaurier, C
   Even, P
   Launay, JM
   Carraro, V
   Maurin, AC
   Averous, J
   Chaveroux, C
   Bruhat, A
   Mallet, J
   Morio, B
   Fafournoux, P
AF Jousse, Celine
   Muranishi, Yuki
   Parry, Laurent
   Montaurier, Christophe
   Even, Patrick
   Launay, Jean-Marie
   Carraro, Valerie
   Maurin, Anne-Catherine
   Averous, Julien
   Chaveroux, Cedric
   Bruhat, Alain
   Mallet, Jacques
   Morio, Beatrice
   Fafournoux, Pierre
TI Perinatal Protein Malnutrition Affects Mitochondrial Function in Adult
   and Results in a Resistance to High Fat Diet-Induced Obesity
SO PLOS ONE
LA English
DT Article
ID CYTOCHROME-C-OXIDASE; IMPAIRED OXIDATIVE-PHOSPHORYLATION;
   LOCAL-ANESTHETIC BUPIVACAINE; GROWTH-RETARDED RATS; UNCOUPLING
   PROTEIN-2; ENERGY-METABOLISM; ADIPOSE-TISSUE; MUSCLE MITOCHONDRIAL;
   INSULIN-RESISTANCE; LIPID-METABOLISM
AB Epidemiological findings indicate that transient environmental influences during perinatal life, especially nutrition, may have deleterious heritable health effects lasting for the entire life. Indeed, the fetal organism develops specific adaptations that permanently change its physiology/metabolism and that persist even in the absence of the stimulus that initiated them. This process is termed "nutritional programming". We previously demonstrated that mothers fed a Low-Protein-Diet (LPD) during gestation and lactation give birth to F1-LPD animals presenting metabolic consequences that are different from those observed when the nutritional stress is applied during gestation only. Compared to control mice, adult F1-LPD animals have a lower body weight and exhibit a higher food intake suggesting that maternal protein under-nutrition during gestation and lactation affects the energy metabolism of F1-LPD offspring. In this study, we investigated the origin of this apparent energy wasting process in F1-LPD and demonstrated that minimal energy expenditure is increased, due to both an increased mitochondrial function in skeletal muscle and an increased mitochondrial density in White Adipose Tissue. Importantly, F1-LPD mice are protected against high-fat-diet-induced obesity. Clearly, different paradigms of exposure to malnutrition may be associated with differences in energy expenditure, food intake, weight and different susceptibilities to various symptoms associated with metabolic syndrome. Taken together these results demonstrate that intra-uterine environment is a major contributor to the future of individuals and disturbance at a critical period of development may compromise their health. Consequently, understanding the molecular mechanisms may give access to useful knowledge regarding the onset of metabolic diseases.
C1 [Jousse, Celine; Muranishi, Yuki; Parry, Laurent; Montaurier, Christophe; Carraro, Valerie; Maurin, Anne-Catherine; Averous, Julien; Chaveroux, Cedric; Bruhat, Alain; Morio, Beatrice; Fafournoux, Pierre] Univ Clermont 1, INRA, Nutr Humaine UMR1019, St Genes Champanelle, France.
   [Even, Patrick] AgroParisTech, INRA, Nutr Physiol & Ingest Behav UMR914, Paris, France.
   [Launay, Jean-Marie] Univ Paris 05, Hop Lariboisiere, AP HP,Fac Pharm, Serv Biochim & Biol Mol,Equipe Associee EA 3621, Paris, France.
   [Mallet, Jacques] Univ Paris 06, CNRS, Hop La Pitie Salpetriere, Lab Genet Mol Neurotransmiss & Proc,UMR7091, Paris, France.
C3 Universite Clermont Auvergne (UCA); INRAE; INRAE; AgroParisTech;
   Universite Paris Saclay; Assistance Publique Hopitaux Paris (APHP);
   Universite Paris Cite; Hopital Universitaire Lariboisiere-Fernand-Widal
   - APHP; Sorbonne Universite; Assistance Publique Hopitaux Paris (APHP);
   Hopital Universitaire Pitie-Salpetriere - APHP; Centre National de la
   Recherche Scientifique (CNRS)
RP Jousse, C (corresponding author), Univ Clermont 1, INRA, Nutr Humaine UMR1019, St Genes Champanelle, France.
EM celine.jousse@clermont.inra.fr; pierre.fafournoux@clermont.inra.fr
RI Morio, Béatrice/JCD-6492-2023; jousse, celine/NDS-0480-2025; MONTAURIER,
   Christophe/AAB-9460-2022; Morio, Beatrice/G-3571-2018
OI Montaurier, Christophe/0000-0001-5487-8757; Chaveroux,
   Cedric/0000-0002-4116-3354; Carmen, Team2/0000-0001-9867-5724;
   MURANISHI, Yuki/0000-0001-8784-2136; Carmen, Team1/0000-0003-4234-1746;
   Lab, Carmen/0000-0002-5935-3236; Even, Patrick/0000-0001-5733-3023;
   Morio, Beatrice/0000-0002-2418-1438
FU ANR (French Agency for Research, Epidiabesity)
FX The study was funded by a grant from ANR (French Agency for Research,
   Epidiabesity). The Centre National pour la Recherche Scientifique (CNRS)
   provided salaries for CJ and PF. The funders had no role in study
   design, data collection and analysis, decision to publish, or
   preparation of the manuscript.
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NR 38
TC 28
Z9 31
U1 0
U2 17
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD AUG 13
PY 2014
VL 9
IS 8
AR e104896
DI 10.1371/journal.pone.0104896
PG 12
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA AN9BM
UT WOS:000340900600102
PM 25118945
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Belo, L
   Nascimento, H
   Kohlova, M
   Bronze-da-Rocha, E
   Fernandes, J
   Costa, E
   Catarino, C
   Aires, L
   Mansilha, HF
   Rocha-Pereira, P
   Quintanilha, A
   Rêgo, C
   Santos-Silva, A
AF Belo, Luis
   Nascimento, Henrique
   Kohlova, Michaela
   Bronze-da-Rocha, Elsa
   Fernandes, Joao
   Costa, Elisio
   Catarino, Cristina
   Aires, Luisa
   Mansilha, Helena Ferreira
   Rocha-Pereira, Petronila
   Quintanilha, Alexandre
   Rego, Carla
   Santos-Silva, Alice
TI Body Fat Percentage Is a Major Determinant of Total Bilirubin
   Independently of UGT1A1*28 Polymorphism in Young Obese
SO PLOS ONE
LA English
DT Article
ID SERUM BILIRUBIN; INSULIN-RESISTANCE; METABOLIC SYNDROME; OXIDATIVE
   STRESS; ENDOTHELIAL FUNCTION; INVERSE RELATIONSHIP; RACIAL VARIABILITY;
   CLINICAL-PRACTICE; MASS INDEX; GENE
AB Objectives: Bilirubin has potential antioxidant and anti-inflammatory properties. The UGT1A1*28 polymorphism (TA repeats in the promoter region) is a major determinant of bilirubin levels and recent evidence suggests that raised adiposity may also be a contributing factor. We aimed to study the interaction between UGT1A1 polymorphism, hematological and anthropometric variables with total bilirubin levels in young individuals.
   Methods: 350 obese (mean age of 11.6 years; 52% females) and 79 controls (mean age of 10.5 years; 59% females) were included. Total bilirubin and C-reactive protein (CRP) plasma levels, hemogram, anthropometric data and UGT1A1 polymorphism were determined. In a subgroup of 74 obese and 40 controls body composition was analyzed by dual-energy X-ray absorptiometry.
   Results: The UGT1A1 genotype frequencies were 49.9%, 42.7% and 7.5% for 6/6, 6/7 and 7/7 genotypes, respectively. Patients with 7/7 genotype presented the highest total bilirubin levels, followed by 6/7 and 6/6 genotypes. Compared to controls, obese patients presented higher erythrocyte count, hematocrit, hemoglobin and CRP levels, but no differences in bilirubin or in UGT1A1 genotype distribution. Body fat percentage was inversely correlated with bilirubin in obese patients but not in controls. This inverse association was observed either in 6/7 or 6/6 genotype obese patients. UGT1A1 polymorphism and body fat percentage were the main factors affecting bilirubin levels within obese patients (linear regression analysis).
   Conclusion: In obese children and adolescents, body fat composition and UGT1A1 polymorphism are independent determinants of total bilirubin levels. Obese individuals with 6/6 UGT1A1 genotype and higher body fat mass may benefit from a closer clinical follow-up.
C1 [Belo, Luis; Nascimento, Henrique; Bronze-da-Rocha, Elsa; Fernandes, Joao; Costa, Elisio; Catarino, Cristina; Santos-Silva, Alice] Univ Porto, Fac Farm, Dept Ciencias Biol, P-4100 Oporto, Portugal.
   [Belo, Luis; Nascimento, Henrique; Bronze-da-Rocha, Elsa; Costa, Elisio; Catarino, Cristina; Quintanilha, Alexandre; Santos-Silva, Alice] Univ Porto, IBMC, P-4100 Oporto, Portugal.
   [Kohlova, Michaela; Fernandes, Joao] Univ Coimbra, Fac Med, Inst Biomed Imaging & Life Sci IBILI, Coimbra, Portugal.
   [Aires, Luisa] Univ Porto, Ctr Invest Actividade Fis Saude & Lazer CIAFEL, Fac Desporto, P-4100 Oporto, Portugal.
   [Aires, Luisa] Inst Univ Maia ISMAI, Maia, Portugal.
   [Mansilha, Helena Ferreira] Ctr Hosp Porto, Dept Infancia & Adolescencia, Serv Pediat, Oporto, Portugal.
   [Rocha-Pereira, Petronila] Univ Beira Interior, Ctr Invest Ciencias Saude, Covilha, Portugal.
   [Quintanilha, Alexandre] Univ Porto, ICBAS, P-4100 Oporto, Portugal.
   [Rego, Carla] Univ Porto, Fac Med, Ctr Hlth Technol & Serv Res CINTESIS, Hosp CUF Porto,Ctr Crianca & Adolescente, P-4100 Oporto, Portugal.
C3 Universidade do Porto; Universidade do Porto; Universidade de Coimbra;
   Universidade do Porto; Instituto Universitario da Maia (ISMAI);
   Universidade da Beira Interior; Universidade do Porto; Universidade do
   Porto
RP Belo, L (corresponding author), Univ Porto, Fac Farm, Dept Ciencias Biol, Rua Campo Alegre 823, P-4100 Oporto, Portugal.
EM luisbelo@ff.up.pt
RI Aires, Luisa/L-7528-2013; Santos-Silva, Alice/AAC-7082-2020; Rego,
   Carla/L-8027-2013; Fernandes, Joao/AAF-2091-2019; Costa,
   Elisio/K-1990-2013; Rocha-Pereira, Petronila/K-3102-2013; Kohlova,
   Michaela/T-3587-2017; Bronze da Rocha, Elsa/K-2723-2013; Santos-Silva,
   Alice/K-2326-2013; Catarino, Cristina/K-5492-2013; Quintanilha,
   Alexandre/L-5371-2013; Fernandes, Joao/K-3126-2013; Belo,
   Luis/K-5878-2013
OI Rego, Carla/0000-0003-1229-8775; Costa, Elisio/0000-0003-1158-1480;
   Rocha-Pereira, Petronila/0000-0002-7985-1494; Kohlova,
   Michaela/0000-0002-9411-3449; Bronze da Rocha, Elsa/0000-0002-3571-2513;
   Santos-Silva, Alice/0000-0002-2565-3169; Nascimento,
   Henrique/0000-0002-9105-018X; Catarino, Cristina/0000-0002-3229-1434;
   Aires, Luisa/0000-0001-9717-4186; Quintanilha,
   Alexandre/0000-0001-8544-0061; Fernandes, Joao/0000-0003-1556-1698;
   Belo, Luis/0000-0002-3941-6850
FU FEDER funds through the Operational Competitiveness Programme - COMPETE;
   National Funds through FCT - Fundacao para a Ciencia e a Tecnologia
   [FCOMP-01-0124-FEDER-028613 (PTDC/DTP-DES/0393/2012)]; FCT
   [SFRH/BD/48060/2008]; Fundação para a Ciência e a Tecnologia
   [PTDC/DTP-DES/0393/2012] Funding Source: FCT
FX This work was funded by FEDER funds through the Operational
   Competitiveness Programme - COMPETE and by National Funds through FCT -
   Fundacao para a Ciencia e a Tecnologia under the project
   FCOMP-01-0124-FEDER-028613 (PTDC/DTP-DES/0393/2012). A PhD grant was
   attributed to H. Nascimento by FCT (SFRH/BD/48060/2008). The funders had
   no role in study design, data collection and analysis, decision to
   publish, or preparation of the manuscript.
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NR 49
TC 24
Z9 26
U1 0
U2 7
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JUN 5
PY 2014
VL 9
IS 6
AR e98467
DI 10.1371/journal.pone.0098467
PG 9
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA AI4NF
UT WOS:000336841400032
PM 24901842
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Chheda, TK
   Shivakumar, P
   Sadasivan, SK
   Chanderasekharan, H
   Moolemath, Y
   Oommen, AM
   Madanahalli, JR
   Marikunte, VV
AF Chheda, Tarak K.
   Shivakumar, Pratibha
   Sadasivan, Satish Kumar
   Chanderasekharan, Harish
   Moolemath, Yogananda
   Oommen, Anup M.
   Madanahalli, Jagannath R.
   Marikunte, Venkataranganna V.
TI Fast food diet with CCl4 micro-dose induced hepatic-fibrosis -a novel
   animal model
SO BMC GASTROENTEROLOGY
LA English
DT Article
ID FATTY LIVER-DISEASE; NONALCOHOLIC STEATOHEPATITIS; CARBON-TETRACHLORIDE;
   FRUCTOSE CONSUMPTION; METABOLIC SYNDROME; GENE-EXPRESSION; MOUSE;
   STEATOSIS; EPIDEMIOLOGY; MECHANISMS
AB Background: Non-alcoholic fatty liver disease (NAFLD) is defined as a spectrum of conditions ranging from hepatocellular steatosis to steatohepatitis and fibrosis, progressing to cirrhosis, which occur in the absence of excessive alcohol use. Several animal models capture aspects of NAFLD but are limited either in their representation of the disease stages or use for development of therapeutics due to the extended periods of time required to develop full histological features.
   Methods: Here, we report the development of a novel rat model for NAFLD that addresses some of these limitations. We used a fast food diet (FFD) and a CCl4 micro dose (0.5 ml/ kg B. wt) for 8 weeks in Wistar rats. Serological analyses, gene expression profiling and liver histology studies were conducted to investigate the development of steatosis, steatohepatitis and fibrosis in the FFD-CCl4 model when compared to the individual effects of a FFD or a micro dose of CCl4 in rats.
   Results: The serum biochemical profile of the FFD-CCl4 model showed an increase in liver injury and fibrosis. This was also accompanied by a significant increase in liver triglycerides (TG), inflammation and oxidative stress. Importantly, we observed extensive fibrosis confirmed by: i) increased gene expression of fibrosis markers and, ii) moderate to severe collagen deposition seen as perisinusoidal and bridging fibrosis using H& E, Trichome and Sirius Red staining.
   Conclusions: In summary, we find that the FFD-CCl4 rat model developed NAFLD histological features including, steatosis, inflammation and fibrosis in 8 weeks showing promise as a model that can be used to develop NAFLD therapeutics and liver anti-fibrotics.
C1 [Chheda, Tarak K.; Shivakumar, Pratibha; Sadasivan, Satish Kumar; Chanderasekharan, Harish; Moolemath, Yogananda; Marikunte, Venkataranganna V.] Connexios Life Sci Pvt Ltd, Preclin Dev, Bangalore, Karnataka, India.
   [Oommen, Anup M.] Connexios Life Sci Pvt Ltd, Syst Biol Grp, Bangalore, Karnataka, India.
   [Madanahalli, Jagannath R.] Connexios Life Sci Pvt Ltd, Drug Discovery Grp, Bangalore, Karnataka, India.
RP Marikunte, VV (corresponding author), Connexios Life Sci Pvt Ltd, Preclin Dev, Bangalore, Karnataka, India.
EM m.v.venkataranganna@connexios.com
RI Moolemath, Yogananda/T-2872-2019
OI Oommen, Anup/0000-0001-7653-5106
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NR 48
TC 22
Z9 22
U1 0
U2 6
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1471-230X
J9 BMC GASTROENTEROL
JI BMC Gastroenterol.
PD MAY 10
PY 2014
VL 14
AR 89
DI 10.1186/1471-230X-14-89
PG 9
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA AI2FC
UT WOS:000336671900001
PM 24884574
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Thilakchand, KR
   Mathai, RT
   Simon, P
   Ravi, RT
   Baliga-Rao, MP
   Baliga, MS
AF Thilakchand, Karadka Ramdas
   Mathai, Rashmi Teresa
   Simon, Paul
   Ravi, Rithin T.
   Baliga-Rao, Manjeshwar Poonam
   Baliga, Manjeshwar Shrinath
TI Hepatoprotective properties of the Indian gooseberry (Emblica
   officinalis Gaertn): a review
SO FOOD & FUNCTION
LA English
DT Review
ID INDUCED OXIDATIVE STRESS; INDUCED LIVER-DAMAGE; PHYLLANTHUS FRUIT
   EXTRACT; TERMINALIA-BELERICA; SCAVENGING ACTIVITY; FIBROGENIC EVENTS;
   PROTECTIVE ROLE; GALLIC ACID; ANTIOXIDANT; QUERCETIN
AB Liver diseases characterized by inflammation or tissue damage affect the optimal functioning and increase the morbidity and mortality of the affected individual. Liver diseases are a largely neglected health issue and recent reports indicate that they affect over 10% of the world population, with the highest burden in low and middle income countries that have minimal medical resources. To complicate matters the currently available pharmacological therapies are not optimal and when used for extended periods of time impart systemic toxicity. Diet can modify pathophysiological processes, including those of hepatotoxins, and studies have shown that some dietary constituents can afford heptoprotection. Emblica officinalis Gaertn or Phyllanthus emblica Linn, commonly known as the Indian gooseberry in English or amla in Hindi, is one of the most important medicinal and dietary plants in the Indian subcontinent. The fruits are of dietary and medicinal use and have wide applications in both traditional and folk systems of medicine. Scientific studies have shown amla to be effective in preventing/ameliorating the toxic effects of hepatotoxic agents like ethanol, paracetamol, carbon tetrachloride, heavy metals, ochratoxins, hexachlorocyclohexane, antitubercular drugs and hepatotoxicity resulting from iron overload. Amla is also reported to impart beneficial effects on liver function and to mitigate hyperlipidemia and metabolic syndrome. Amla possesses protective effects against chemical-induced hepatocarcinogenesis in animal models of study. Additionally, the phytochemicals quercetin, gallic acid, corilagin and ellagic acid are also reported to protect against the cytotoxic effects of paracetamol, microcystins, galactosamine and lipopolysaccharide. The hepatoprotective actions of amla appear to be mediated by its free radical scavenging, antioxidant, anti-inflammatory and modulation of the xenobiotic detoxification process and lipid metabolism.
C1 [Thilakchand, Karadka Ramdas; Simon, Paul; Ravi, Rithin T.; Baliga, Manjeshwar Shrinath] Father Muller Med Coll, Res Ctr, Mangalore 575002, Karnataka, India.
   [Mathai, Rashmi Teresa] Father Muller Med Coll, Dept Gen Med, Mangalore 575002, Karnataka, India.
   [Baliga-Rao, Manjeshwar Poonam] Mangalore Inst Oncol, Dept Pharm, Mangalore 575002, Karnataka, India.
C3 Father Muller Medical College; Father Muller Medical College
RP Thilakchand, KR (corresponding author), Father Muller Med Coll, Res Ctr, Father Muller Hosp Rd, Mangalore 575002, Karnataka, India.
EM msbaliga@gmail.com
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NR 83
TC 34
Z9 39
U1 2
U2 53
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PD OCT
PY 2013
VL 4
IS 10
BP 1431
EP 1441
DI 10.1039/c3fo60237k
PG 11
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA 225SZ
UT WOS:000324984200001
PM 23978895
DA 2025-06-11
ER

PT J
AU Haimeur, A
   Messaouri, H
   Ulmann, L
   Mimouni, V
   Masrar, A
   Chraibi, A
   Tremblin, G
   Meskini, N
AF Haimeur, Adil
   Messaouri, Hafida
   Ulmann, Lionel
   Mimouni, Virginie
   Masrar, Azelarab
   Chraibi, Abdelmjid
   Tremblin, Gerard
   Meskini, Nadia
TI Argan oil prevents prothrombotic complications by lowering lipid levels
   and platelet aggregation, enhancing oxidative status in dyslipidemic
   patients from the area of Rabat (Morocco)
SO LIPIDS IN HEALTH AND DISEASE
LA English
DT Article
DE Platelet aggregation; Argan oil; Dyslipidemia; Oxidative stress
ID DENSITY-LIPOPROTEIN CHOLESTEROL; METABOLIC SYNDROME; SPINOSA L.;
   FATTY-ACIDS; DIETARY-SUPPLEMENT; PHENOLIC-COMPOUNDS; ENZYME-ACTIVITIES;
   LDL OXIDATION; PLASMA; INTERVENTION
AB Background: It is now established that patients with hyperlipidemia have a high risk of atherosclerosis and thrombotic complications, which are two important events responsible for the onset and progression of cardiovascular disease. In the context of managing dyslipidemia by means of dietary advice based on the consumption of argan oil, we wanted to investigate the effect of virgin argan oil on plasma lipids, and for the first time, on the platelet hyperactivation and oxidative status associated with dyslipidemia. This study concerns patients recruited in the area of Rabat in Morocco.
   Methods: 39 dyslipidemic (79% women) patients were recruited for our study in the area of Rabat in Morocco. They were randomly assigned to the two following groups: the argan group, in which the subjects consumed 25 mL/day of argan oil at breakfast for 3 weeks, and the control group in which argan oil was replaced by butter.
   Results: After a 3-week consumption period, blood total cholesterol was significantly lower in the argan oil group, as was LDL cholesterol (23.8% and 25.6% lower, respectively). However, the HDL cholesterol level had increased by 26% at the end of the intervention period compared to baseline. Interestingly, in the argan oil group thrombin-induced platelet aggregation was lower, and oxidative status was enhanced as a result of lower platelet MDA and higher GPx activity, respectively.
   Conclusions: In conclusion, our results, even if it is not representative of the Moroccan population, show that argan oil can prevent the prothrombotic complications associated with dyslipidemia, which are a major risk factor for cardiovascular disease.
C1 [Haimeur, Adil; Ulmann, Lionel; Mimouni, Virginie; Tremblin, Gerard] Univ Maine, IUT Dept Genie Biol, Fac Sci & Tech, PRES LUNAM,EA MMS Mer Mol Sante 2160, Le Mans, Laval, France.
   [Haimeur, Adil; Messaouri, Hafida; Meskini, Nadia] Univ Hassan 2, Equipe Nutr, Lab Virol Microbil Qual Ecotoxicol & Biodivers, Fac Sci & Tech, Mohammadia, Morocco.
   [Masrar, Azelarab] Ctr Hosp Univ Ibn Sina, Serv Endocrinol Diabetol & Nutr, Rabat, Morocco.
   [Chraibi, Abdelmjid] Ctr Hosp Univ Ibn Sina, Hemostase Lab, Fac Med & Pharm, Rabat, Morocco.
C3 Le Mans Universite; Hassan II University of Casablanca; Mohammed V
   University in Rabat; Ibn sina University Hospital Center of Rabat;
   Mohammed V University in Rabat; Ibn sina University Hospital Center of
   Rabat
RP Meskini, N (corresponding author), Univ Hassan 2, Equipe Nutr, Lab Virol Microbil Qual Ecotoxicol & Biodivers, Fac Sci & Tech, Mohammadia, Morocco.
EM nadia_meskini@hotmail.com
RI HAIMEUR, Adil/D-4009-2015; Ulmann, Lionel/AAC-6561-2019
OI Ulmann, Lionel/0000-0002-9009-2791; MESSAOURI,
   Hafida/0000-0002-1496-640X; Mimouni, Virginie/0000-0002-2468-0659
FU French Foreign Affairs Ministry [MA/21/61]; Moroccan Ministry of
   Research and Higher Education
FX The research is supported by an "accord programme PHC-Volubilis n
   degrees MA/21/61 with joint financial support from the French Foreign
   Affairs Ministry and the Moroccan Ministry of Research and Higher
   Education. The authors gratefully thank Zakaria Ouissafane for providing
   the argan oil used in this study. We would also like to thank the
   doctors and the nursing staff at the Endocrinology, Diabetology and
   Nutrition Department of the Ibn Sina University Hospital, Rabat, Morocco
   for their assistance in carrying out physical examinations and
   collecting blood. Our grateful thanks also to the technical staff of the
   Hemostasis Laboratory at the Ibn Sina University Hospital, Rabat,
   Morocco for their warm reception. The authors would also like to thank
   M. Ghosh for reviewing the English text.
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NR 62
TC 16
Z9 16
U1 0
U2 17
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1476-511X
J9 LIPIDS HEALTH DIS
JI Lipids Health Dis.
PD JUL 20
PY 2013
VL 12
DI 10.1186/1476-511X-12-107
PG 9
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA 203OE
UT WOS:000323301700001
PM 23870174
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Noguchi, N
   Konishi, F
   Kumamoto, S
   Maruyama, I
   Ando, Y
   Yanagita, T
AF Noguchi, Naoto
   Konishi, Fumiko
   Kumamoto, Shoichiro
   Maruyama, Isao
   Ando, Yotaro
   Yanagita, Teruyoshi
TI Beneficial effects of Chlorella on glucose and lipid metabolism
   in obese rodents on a high-fat diet
SO OBESITY RESEARCH & CLINICAL PRACTICE
LA English
DT Article
DE Chlorella; Adiponectin; MCP-1; Leptin; Metabolic syndrome
ID INSULIN-RESISTANCE; OXIDATIVE STRESS; ADIPOSE-TISSUE; RECEPTOR-ALPHA;
   RATS; ADIPONECTIN; CHOLESTEROL; VULGARIS; MICE; HYPERTENSION
AB Background: Obesity-induced glucose and lipid metabolism disorders have become risk factors for lifestyle diseases. Powderized Parachlorella beijerinckii (BP) and its hot water extract (BCEx) are believed to be useful for preventing common diseases such as hypertension, arteriosclerosis, and hyperlipidemia. The present study investigated how chlorella components influence common diseases in obese mice and rats on a high-fat diet.
   Methods: We fed C57BL/6J mice a high-fat diet containing 5% BP, and then weighed their organs, tested their glucose tolerance and insulin sensitivity, and analyzed their serum. Further, we fed Sprague-Dawley rats with a high-fat diet containing 1% BCEx, and then weighed their organs and analyzed their serum parameters.
   Results: BP administration had no effect on high-fat diet-induced obesity. However, compared with high-fat diet group, BP group had improved glucose tolerance and insulin sensitivity and inhibited the hypertrophic growth of visceral fat cells. In addition, BP group had improved serum adiponectin, leptin and monocyte chemoattractant protein-1 (MCP-1) levels. The MCP-1 expression level at epididymal fat was decreased at BP group. BCEx administration reduced amount of peritesticular fat and serum triglyceride (TG) levels.
   Conclusions: The results suggest that the antihyperinsulinemic effects of BP are due to the modulation of adipose tissue hypertrophy and adipocytokine secretion. BCEx inhibited the accumulation of visceral fat and serum TG. The study showed that BP and BCEx improve glucose and lipid metabolism disorders caused by a high-fat diet. (C) 2013 Asian Oceanian Association for the Study of Obesity. Published by Elsevier Ltd. All rights reserved.
C1 [Noguchi, Naoto; Konishi, Fumiko; Kumamoto, Shoichiro; Maruyama, Isao; Ando, Yotaro] Chlorella Ind Co Ltd, Dept Res & Dev, Fukuoka 8330056, Japan.
   [Yanagita, Teruyoshi] Saga Univ, Dept Appl Biochem & Food Sci, Saga 8408502, Japan.
   [Yanagita, Teruyoshi] Nishikyushu Univ, Fac Hlth & Social Welf Sci, Dept Hlth & Nutr Sci, Saga 8428585, Japan.
C3 Saga University
RP Noguchi, N (corresponding author), Chlorella Ind Co Ltd, Dept Res & Dev, 1343 Hisatomi, Fukuoka 8330056, Japan.
EM naoto_noguchi@chlorella.co.jp
RI Ando, Yuichi/Q-1418-2015
OI Noguchi, Naoto/0000-0002-2597-6101; Ando, Yukio/0000-0001-7115-9105
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NR 33
TC 26
Z9 26
U1 0
U2 22
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1871-403X
J9 OBES RES CLIN PRACT
JI Obes. Res. Clin. Pract.
PD MAR-APR
PY 2013
VL 7
IS 2
BP E95
EP E105
DI 10.1016/j.orcp.2013.01.002
PG 11
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 114IT
UT WOS:000316735000002
PM 24331771
DA 2025-06-11
ER

PT J
AU O'Bryant, SE
   Xiao, GH
   Edwards, M
   Devous, M
   Gupta, VB
   Martins, R
   Zhang, F
   Barber, R
AF O'Bryant, Sid E.
   Xiao, Guanghua
   Edwards, Melissa
   Devous, Michael
   Gupta, Veer Bala
   Martins, Ralph
   Zhang, Fan
   Barber, Robert
CA Texas Alzheimer's Res Care Consort
TI Biomarkers of Alzheimer's Disease Among Mexican Americans
SO JOURNAL OF ALZHEIMERS DISEASE
LA English
DT Article
DE Alzheimer's disease; biomarkers; Mexican American; neuropsychology
ID SACRAMENTO AREA LATINO; MILD COGNITIVE IMPAIRMENT; TYPE-2
   DIABETES-MELLITUS; C-REACTIVE PROTEIN; RATING-SCALE SUM; METABOLIC
   SYNDROME; SERUM CONCENTRATIONS; OXIDATIVE STRESS; FOLLOW-UP; DEMENTIA
AB Background: Mexican Americans are the fastest aging segment of the U. S. population, yet little scientific literature exists regarding the Alzheimer's disease (AD) among this segment of the population. The extant literature suggests that biomarkers of AD will vary according to race/ethnicity though no prior work has explicitly studied this possibility. The aim of this study was to create a serum-based biomarker profile of AD among Mexican American.
   Methods: Data were analyzed from 363 Mexican American participants (49 AD and 314 normal controls) enrolled in the Texas Alzheimer's Research & Care Consortium (TARCC). Non-fasting serum samples were analyzed using a luminex-based multi-plex platform. A biomarker profile was generated using random forest analyses.
   Results: The biomarker profile of AD among Mexican Americans was different from prior work from non-Hispanic populations with regards to the variable importance plots. In fact, many of the top markers were related to metabolic factors (e. g., FABP, GLP-1, CD40, pancreatic polypeptide, insulin-like-growth factor, and insulin). The biomarker profile was a significant classifier of AD status yielding an area under the receiver operating characteristic curve, sensitivity, and specificity of 0.77, 0.92, and 0.64, respectively. Combining biomarkers with clinical variables yielded a better balance of sensitivity and specificity.
   Conclusion: The biomarker profile for AD among Mexican American cases is significantly different from that previously identified among non-Hispanic cases from many large-scale studies. This is the first study to explicitly examine and provide support for blood-based biomarkers of AD among Mexican Americans. Areas for future research are highlighted.
C1 [O'Bryant, Sid E.; Edwards, Melissa] Univ N Texas, Hlth Sci Ctr, Dept Internal Med, Ft Worth, TX 76107 USA.
   [O'Bryant, Sid E.; Barber, Robert] Univ N Texas, Hlth Sci Ctr, Inst Aging & Alzheimers Dis Res, Ft Worth, TX 76107 USA.
   [Xiao, Guanghua] Univ Texas SW Med Ctr Dallas, Dept Clin Sci, Dallas, TX 75390 USA.
   [Edwards, Melissa] Univ N Texas, Dept Clin Hlth Psychol, Denton, TX 76203 USA.
   [Devous, Michael] Univ Texas SW Med Ctr Dallas, Dept Neurol & Neurotherapeut, Dallas, TX 75390 USA.
   [Gupta, Veer Bala; Martins, Ralph] Edith Cowan Univ, Sch Med Sci, Ctr Excellence Alzheimers Dis Res & Care, Joondalup, WA, Australia.
   [Gupta, Veer Bala; Martins, Ralph] Hollywood Private Hosp, Sir James McCusker Alzheimers Dis Res Unit, Perth, WA, Australia.
   [Zhang, Fan] Univ N Texas, Hlth Sci Ctr, Dept Acad & Inst Resources & Technol, Ft Worth, TX 76107 USA.
   [Barber, Robert] Univ N Texas, Dept Pharmacol, Hlth Sci Ctr, Ft Worth, TX 76107 USA.
C3 University of North Texas System; University of North Texas Health
   Science Center; University of North Texas System; University of North
   Texas Health Science Center; University of Texas System; University of
   Texas Southwestern Medical Center Dallas; University of North Texas
   System; University of North Texas Denton; University of Texas System;
   University of Texas Southwestern Medical Center Dallas; Edith Cowan
   University; University of Western Australia; University of North Texas
   System; University of North Texas Health Science Center; University of
   North Texas System; University of North Texas Health Science Center
RP O'Bryant, SE (corresponding author), Univ N Texas, Hlth Sci Ctr, Dept Internal Med, 3500 Camp Bowie Blvd, Ft Worth, TX 76107 USA.
EM Sid.O'Bryant@unthsc.edu
RI Gupta, Vivek Kumar/AAB-8940-2022
OI O'Bryant, Sid/0000-0003-0582-5266; Gupta, Veer/0000-0003-4989-0764;
   Martins, Ralph/0000-0002-4828-9363
FU state of Texas through the Texas Council on Alzheimer's Disease and
   Related Disorders; National Institute on Aging (NIA) and National
   Institute on Minority Health and Health Disparities (NIMHD) of the
   National Institutes of Health [R01AG039389, P30AG12300, L60MD001849]
FX This study was made possible by the Texas Alzheimer's Research and Care
   Consortium (TARCC) funded by the state of Texas through the Texas
   Council on Alzheimer's Disease and Related Disorders. Research reported
   in this publication was supported by the National Institute on Aging
   (NIA) and National Institute on Minority Health and Health Disparities
   (NIMHD) of the National Institutes of Health under Award Numbers
   R01AG039389, P30AG12300, and L60MD001849. The content is solely the
   responsibility of the authors and does not necessarily represent the
   official views of the National Institutes of Health. We would like to
   thank all of the participants of the TARCC along with the incredible
   support staff that make this study possible.
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NR 70
TC 60
Z9 66
U1 0
U2 28
PU IOS PRESS
PI AMSTERDAM
PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS
SN 1387-2877
EI 1875-8908
J9 J ALZHEIMERS DIS
JI J. Alzheimers Dis.
PY 2013
VL 34
IS 4
BP 841
EP 849
DI 10.3233/JAD-122074
PG 9
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 110SA
UT WOS:000316464700004
PM 23313927
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Jacobson, BH
AF Jacobson, Bert H.
TI ANTHROPOMETRIC CROSS-SECTIONAL COMPARISONS OF COLLEGE FOOTBALL PLAYERS
   AND POTENTIAL HEALTH IMPLICATIONS
SO JOURNAL OF STRENGTH AND CONDITIONING RESEARCH
LA English
DT Article
DE characteristics; body size; morphology; obesity; size; risk
ID METABOLIC SYNDROME; HEAD IMPACTS; PERFORMANCE-CHARACTERISTICS; AMERICAN
   FOOTBALL; LEAGUE LINEMEN; CONCUSSION; ASSOCIATION; OVERWEIGHT; SIZE;
   RISK
AB Jacobson, BH. Anthropometric cross-sectional comparisons of college football players and potential health implications. J Strength Cond Res 26(12): 3358-3364, 2012-Current college football players appear to be larger in stature than those of the past, but few comparisons exist that have quantified such data over the span of over half a century. The purpose of this study was to compare anthropometric changes in college football players over a period of 7 decades and to address the health implications associated with extreme size. Offensive and defensive positions were targeted based on line play (offensive linemen [OLs] and defensive linemen [DLs]) or speed positions (wide receivers [WRs] and cornerbacks [DBs]), and data on height and weight were collected from official rosters provided by the participating National Collegiate Athletic Association Division I universities. The results indicated that OL significantly (p < 0.001) increased 50.8% in body weight (88.5 vs. 133.5 kg) and 5.4% in height, DLs significantly increased 50.9% in weight (87.2 vs. 131.6 kg) and 6.7% in height, WRs increased 7.7% in weight (79.3 vs. 85.5 kg) and 1.9% in height, and cornerbacks increased 10.1% in weight (78 vs. 86.7 kg) and 2.3% in height since 1950. There were no significant differences in weight by offensive line position (center, guard, and tackle) and no significant differences among class status. The extraordinary size of linemen begins in high school and is sustained through college and the pros. Without efforts in detraining, such extreme sizes may warrant concerns regarding injury, heat stress, obesity, and general health status.
C1 Oklahoma State Univ, Harrison Hlth & Human Performance Lab, Sch Appl Hlth & Educ Psychol, Stillwater, OK 74078 USA.
C3 Oklahoma State University System; Oklahoma State University - Stillwater
RP Jacobson, BH (corresponding author), Oklahoma State Univ, Harrison Hlth & Human Performance Lab, Sch Appl Hlth & Educ Psychol, Stillwater, OK 74078 USA.
EM bert.jacobson@okstate.edu
CR [Anonymous], FOOTB RECR TEAM RANK
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NR 35
TC 11
Z9 14
U1 0
U2 13
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1064-8011
J9 J STRENGTH COND RES
JI J. Strength Cond. Res.
PD DEC
PY 2012
VL 26
IS 12
BP 3358
EP 3364
DI 10.1519/JSC.0b013e31824b5e6c
PG 7
WC Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Sport Sciences
GA 048FG
UT WOS:000311895100024
PM 22290523
OA Bronze
DA 2025-06-11
ER

PT J
AU Hoehner, CM
   Barlow, CE
   Allen, P
   Schootman, M
AF Hoehner, Christine M.
   Barlow, Carolyn E.
   Allen, Peg
   Schootman, Mario
TI Commuting Distance, Cardiorespiratory Fitness, and Metabolic Risk
SO AMERICAN JOURNAL OF PREVENTIVE MEDICINE
LA English
DT Article
ID CARDIOVASCULAR-DISEASE MORTALITY; PHYSICAL-ACTIVITY; SEDENTARY
   BEHAVIORS; BUILT ENVIRONMENT; URBAN SPRAWL; ALL-CAUSE; OBESITY; STRESS;
   TIME; OVERWEIGHT
AB Background: Limited evidence exists on the metabolic and cardiovascular risk correlates of commuting by vehicle, a habitual form of sedentary behavior.
   Purpose: To examine the association between commuting distance, physical activity, cardiorespiratory fitness (CRF), and metabolic risk indicators.
   Methods: This cross-sectional study included 4297 adults who had a comprehensive medical examination between 2000 and 2007 and geocoded home and work addresses in 12 Texas metropolitan counties. Commuting distance was measured along the road network. Outcome variables included weekly MET-minutes of self-reported physical activity, CRF, BMI, waist circumference, triglycerides, plasma glucose, high-density lipoprotein cholesterol, systolic and diastolic blood pressure, and continuously measured metabolic syndrome. Outcomes were also dichotomized using established cut-points. Linear and logistic regression models were adjusted for sociodemographic characteristics, smoking, alcohol intake, family history of diabetes, and history of high cholesterol, as well as BMI and weekly MET-minutes of physical activity and CRF (for BMI and metabolic risk models). Analyses were conducted in 2011.
   Results: Commuting distance was negatively associated with physical activity and CRF and positively associated with BMI, waist circumference, systolic and diastolic blood pressure, and continuous metabolic score in fully adjusted linear regression models. Logistic regression analyses yielded similar associations; however, of the models with metabolic risk indicators as outcomes, only the associations with elevated blood pressure remained significant after adjustment for physical activity and CRF.
   Conclusions: Commuting distance was adversely associated with physical activity, CRF, adiposity, and indicators of metabolic risk. (Am J Prev Med 2012; 42(6): 571-578) (C) 2012 American Journal of Preventive Medicine
C1 [Hoehner, Christine M.] Washington Univ, Sch Med, Div Publ Hlth Sci, St Louis, MO 63110 USA.
   [Schootman, Mario] Washington Univ, Div Hlth Behav Res, St Louis, MO 63110 USA.
   [Hoehner, Christine M.; Schootman, Mario] Washington Univ, Alvin J Siteman Canc Ctr, St Louis, MO 63110 USA.
   [Allen, Peg] Washington Univ, Brown Sch Social Work, St Louis, MO 63110 USA.
   [Barlow, Carolyn E.] Cooper Inst, Dallas, TX USA.
C3 Washington University (WUSTL); Washington University (WUSTL); Washington
   University (WUSTL); Siteman Cancer Center; Washington University
   (WUSTL); Cooper Institute
RP Hoehner, CM (corresponding author), Washington Univ, Sch Med, Div Publ Hlth Sci, 660 S Euclid Ave,Campus Box 8100, St Louis, MO 63110 USA.
EM hoehnerc@wudosis.wustl.edu
RI wright, beth/V-7496-2019; Schootman, Mario/AAF-3941-2019
OI Schootman, Mario/0000-0003-1162-8824
FU American Cancer Society [MRSG-07-016-01-CPPB]; CDC [U48DP001903]; NIH
   [AG06945, HL62508]; Communities Foundation of Texas
FX This study was supported in part by an American Cancer Society Mentored
   Research Scholar Grant (MRSG-07-016-01-CPPB); CDC, Prevention Research
   Centers Program (Cooperative Agreement U48DP001903); NIH grants (AG06945
   and HL62508); and the Communities Foundation of Texas on recommendation
   of Nancy Ann and Ray L. Hunt. We thank Dr. Kenneth H. Cooper for
   establishing the Cooper Center Longitudinal Study; the Cooper Clinic
   physicians, nurses, and technicians who collected the clinical data; and
   the data management team at the Cooper Institute. We also thank Drs.
   William Haskell and Ross Brownson for their constructive input on the
   design and analysis and Katelin Bugler for preparing the address data.
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NR 64
TC 126
Z9 153
U1 1
U2 48
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0749-3797
EI 1873-2607
J9 AM J PREV MED
JI Am. J. Prev. Med.
PD JUN
PY 2012
VL 42
IS 6
BP 571
EP 578
DI 10.1016/j.amepre.2012.02.020
PG 8
WC Public, Environmental & Occupational Health; Medicine, General &
   Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; General & Internal Medicine
GA 942ZT
UT WOS:000304090900004
PM 22608372
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Lal, C
   Strange, C
   Bachman, D
AF Lal, Chitra
   Strange, Charlie
   Bachman, David
TI Neurocognitive Impairment in Obstructive Sleep Apnea
SO CHEST
LA English
DT Article
ID MILD COGNITIVE IMPAIRMENT; ARMODAFINIL IMPROVES WAKEFULNESS; POSITIVE
   AIRWAY PRESSURE; MIDLIFE BLOOD-PRESSURE; NEUROPSYCHOLOGICAL DEFICITS;
   AUTOMOBILE ACCIDENTS; ALCOHOL-CONSUMPTION; STRUCTURAL-CHANGES; OXIDATIVE
   STRESS; BRAIN INFARCTION
AB Obstructive sleep apnea syndrome (OSAS) is a common disorder with far-reaching health implications. One of the major consequences of OSAS is an impact on neurocognitive functioning. Several studies have shown that OSAS has an adverse effect on inductive and deductive reasoning, attention, vigilance, learning, and memory. Neurocognitive impairment can be measured objectively with tests such as the Wechsler Adult Intelligence Scale-Revised, the Psychomotor Vigilance Task, the Steer Clear Performance Test, and tests of repetitive finger tapping. In children, OSAS may cause attention-deficit hyperactivity disorder in addition to behavioral problems and learning disabilities. Risk factors for cognitive impairment include increasing age, male sex, apolipoprotein E epsilon 4 allele positivity, current cigarette smoking, obesity, hypertension, diabetes mellitus, metabolic syndrome, Down syndrome, hypothyroidism, significant alcohol consumption, stroke, and the use of psychoactive medications. At a cellular level, OSAS likely causes cognitive impairment through intermittent hypoxia, hormonal imbalance, and/or systemic inflammation, either independently or via the resultant endothelial dysfunction that occurs. Excessive daytime sleepiness should be measured and minimized in all studies of neurocognitive impairment. Recent studies have used functional and structural neuroimaging to delineate the brain areas affected in patients with OSAS with neurocognitive dysfunction. A common finding in several of these studies is decreased hippocampal volume. Other affected brain areas include the frontal and parietal lobes of the brain, which show focal reductions in gray matter. These changes can be reversed at least partially with the use of CPAP, which highlights the importance of early recognition and treatment of OSAS. The currently available data in this field are quite limited, and more research is needed. CHEST 2012; 141(6):1601-1610
C1 [Lal, Chitra; Strange, Charlie] Med Univ S Carolina, Div Pulm Crit Care Allergy & Sleep Med, Charleston, SC 29425 USA.
   [Bachman, David] Med Univ S Carolina, Div Neurol, Dept Neurosci, Charleston, SC 29425 USA.
C3 Medical University of South Carolina; Medical University of South
   Carolina
RP Lal, C (corresponding author), Med Univ S Carolina, Div Pulm Crit Care Allergy & Sleep Med, 96 Jonathan Lucas St,CSB 812,MSC 630, Charleston, SC 29425 USA.
EM chitra_lal@hotmail.com
RI lal, chitra/ABB-5992-2021
OI Strange, Charlie/0000-0002-8109-8067
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NR 81
TC 301
Z9 337
U1 0
U2 108
PU AMER COLL CHEST PHYSICIANS
PI NORTHBROOK
PA 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 USA
SN 0012-3692
J9 CHEST
JI Chest
PD JUN
PY 2012
VL 141
IS 6
BP 1601
EP 1610
DI 10.1378/chest.11-2214
PG 10
WC Critical Care Medicine; Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Respiratory System
GA 955RT
UT WOS:000305039300035
PM 22670023
DA 2025-06-11
ER

PT J
AU Piao, Y
   Kim, HG
   Oh, MS
   Pak, YK
AF Piao, Ying
   Kim, Hyo Geun
   Oh, Myung Sook
   Pak, Youngmi Kim
TI Overexpression of TFAM, NRF-1 and myr-AKT protects the
   MPP<SUP>+</SUP>-induced mitochondrial dysfunctions in neuronal cells
SO BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
LA English
DT Article
DE SH-SY5Y; MPP+; Insulin signaling; Mitochondrial dysfunction; Mouse
ID TRANSCRIPTION FACTOR-A; PARKINSONS-DISEASE; INSULIN-RESISTANCE;
   ALZHEIMERS-DISEASE; OXIDATIVE STRESS; ALPHA-SYNUCLEIN; COMPLEX-I; BRAIN;
   PATHOGENESIS; EXPRESSION
AB Background: Mitochondrial dysfunction is a prominent feature of neurodegenerative diseases including Parkinson's disease (PD), in which insulin signaling pathway may also be implicated because 50-80% of PD patients exhibited metabolic syndrome and insulin resistance. 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MFTP) and its toxic metabolite, 1-methyl-4-phenyl-2,3-dihydropyridinium ion (MPP+), inhibit complex I in mitochondrial respiratory chain and are used widely to construct the PD models. But the precise molecular link between mitochondrial damage and insulin signaling remains unclear.
   Methods and results: Using cell-based mitochondrial activity profiling system, we systemically demonstrated that MPP+ suppressed mitochondrial activity and mitochondrial gene expressions mediated by nuclear respiratory factor-1 (NRF-1) and mitochondrial transcription factor A (TFAM) in SH-SY5Y cells. MPP+ fragmented mitochondrial networks and repressed phosphorylation of AKT. Similarly, the expressions of mitochondrial genes and tyrosine hydroxylase and AKT phosphorylation were reduced in substantia nigra and striatum of MPTP-injected mice. Transient transfection of TFAM. NRF-1, or myr-AKT reversed all aspects of the MPP+-mediated changes.
   Conclusions: Mitochondrial activation by TFAM, NRF-1, and myr-AKT abrogated MPP+-mediated damages on mitochondria and insulin signaling, leading to recovery of nigrostriatal neurodegeneration.
   General significance: We suggest that TFAM, NRF-1, and AKT may be the critical points of therapeutic intervention for PD. This article is part of a Special Issue entitled Biochemistry of Mitochondria. (C) 2011 Elsevier B.V. All rights reserved.
C1 [Piao, Ying; Pak, Youngmi Kim] Kyung Hee Univ, Coll Med, Dept Physiol, Neurodegenerat Control Res Ctr,Dept Neurosci, Seoul 130701, South Korea.
   [Kim, Hyo Geun; Oh, Myung Sook] Kyung Hee Univ, Coll Pharm, Dept Oriental Pharmaceut Sci, Dept Life & Nanopharmaceut Sci, Seoul 130701, South Korea.
C3 Kyung Hee University; Kyung Hee University
RP Pak, YK (corresponding author), Kyung Hee Univ, Coll Med, Dept Physiol, Neurodegenerat Control Res Ctr,Dept Neurosci, Hoegi Dong 1, Seoul 130701, South Korea.
EM ykpak@khu.ac.kr
RI Oh, Myung/AAH-9948-2020; Kim, Young/C-9839-2015
OI Pak, Youngmi/0000-0001-7424-3484
FU NRF [20090084158, 20090063278]; 21C Frontier Functional Proteomics
   Project [FPR08A1-070]; MEST, Korea; Kyung Hee University [KHU-20071406,
   KHU-20080903]
FX This study was supported by the NRF grants (20090084158 and 20090063278)
   and FPR08A1-070 of 21C Frontier Functional Proteomics Project funded by
   MEST, Korea and partly by the Kyung Hee University Research Grants
   (KHU-20071406 and KHU-20080903).
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NR 36
TC 68
Z9 73
U1 0
U2 18
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0304-4165
J9 BBA-GEN SUBJECTS
JI Biochim. Biophys. Acta-Gen. Subj.
PD MAY
PY 2012
VL 1820
IS 5
SI SI
BP 577
EP 585
DI 10.1016/j.bbagen.2011.08.007
PG 9
WC Biochemistry & Molecular Biology; Biophysics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics
GA 930JO
UT WOS:000303135900005
PM 21856379
DA 2025-06-11
ER

PT J
AU Knelangen, JM
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   Schagdarsurengin, U
   Fischer, B
   Santos, AN
AF Knelangen, Julia M.
   Kurz, Randy
   Schagdarsurengin, Undraga
   Fischer, Bernd
   Santos, Anne Navarrete
TI Short-time glucose exposure of embryonic carcinoma cells impairs their
   function as terminally differentiated cardiomyocytes
SO BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
LA English
DT Article
DE P19 embryonic carcinoma cells; Cardiac differentiation; Glucose; CpG
   methylation
ID GESTATIONAL DIABETES-MELLITUS; STEM-CELLS; IN-VITRO; PREIMPLANTATION
   EMBRYOS; DEVELOPMENTAL ORIGINS; METABOLIC SYNDROME; INSULIN-RECEPTOR;
   DNA METHYLATION; FETAL-GROWTH; MOUSE
AB The fetal and postnatal phenotype is influenced by developmental conditions experienced prenatally. Among prenatal development metabolic factors are of particular importance as they are supposed to predispose for pathophysiological alterations later in life and to pioneer functional impairment in senescence (metabolic programming). Till now the mechanisms of metabolic programming are not well understood.
   We have investigated various concentrations of glucose during differentiation of pluripotent P19 embryonic carcinoma cells (ECC) into cardiomyocytes. Undifferentiated P19 cells were exposed to 5 mM (low), 25 mM (control), 40 mM or 100 mM (high) glucose for 48 h during embryoid body (EB) formation, followed by plating and differentiation into cardiomyocytes in vitro with standard glucose supplementation (25 mM) for 10-15 days. The amount of cardiac clusters, the frequency of spontaneous beatings as well as the expression of metabolic and cardiac marker genes and their promoter methylation were measured.
   We observed a metabolic programming effect of glucose during cardiac differentiation. Whereas the number of beating clusters and the expression of the cardiac marker alpha myosin heavy chain (alpha-MHC) were comparable in all groups, the frequencies of beating clusters were significantly higher in the high glucose group compared to low glucose. However, neither the insulin receptor (IR) or insulin like growth factor 1 receptor (IGF1R) nor the metabolic gene glucose transporter 4 (GLUT4) were influenced in RNA expression or in promoter methylation.
   Our data indicate that a short time glucose stress during embryonic cell determination leads to lasting effects in terminally differentiated cell function. (C) 2012 Elsevier Inc. All rights reserved.
C1 [Knelangen, Julia M.] Univ Halle Wittenberg, Fac Med, Dept Anat & Cell Biol, D-06097 Halle, Saale, Germany.
   [Kurz, Randy] Univ Leipzig, Div Mol Biol Biochem Proc Technol, Ctr Biotechnol & Biomed, Leipzig, Germany.
   [Schagdarsurengin, Undraga] Univ Giessen, Dept Urol Pediat Urol & Androl, D-35390 Giessen, Germany.
C3 Martin Luther University Halle Wittenberg; Leipzig University; Justus
   Liebig University Giessen
RP Knelangen, JM (corresponding author), Univ Halle Wittenberg, Fac Med, Dept Anat & Cell Biol, Grosse Steinstr 52, D-06097 Halle, Saale, Germany.
EM julia.knelangen@medizin.uni-halle.de
RI Schagdarsurengin, Undraga/AAH-4346-2020
OI Schagdarsurengin, Undraga/0000-0003-0127-4938
FU German National Academic Foundation; German Research Council [DFG NA418]
FX This work was supported by the German National Academic Foundation and
   the German Research Council Grant DFG NA418.
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NR 40
TC 4
Z9 4
U1 0
U2 4
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0006-291X
J9 BIOCHEM BIOPH RES CO
JI Biochem. Biophys. Res. Commun.
PD APR 6
PY 2012
VL 420
IS 2
BP 230
EP 235
DI 10.1016/j.bbrc.2012.02.105
PG 6
WC Biochemistry & Molecular Biology; Biophysics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics
GA 969FW
UT WOS:000306042100003
PM 22405827
DA 2025-06-11
ER

PT J
AU Whaley-Connell, A
   Kurukulasuriya, LR
   Sowers, JR
AF Whaley-Connell, Adam
   Kurukulasuriya, L. Romayne
   Sowers, James R.
TI Renin-Angiotensin-Aldosterone System Inhibition and Improvement in
   Glucose Tolerance
SO JOURNAL OF CLINICAL HYPERTENSION
LA English
DT Review
ID CHRONIC HEART-FAILURE; CONVERTING-ENZYME INHIBITORS; INSULIN-RESISTANCE;
   METABOLIC SYNDROME; OXIDATIVE STRESS; HYPERTENSION; MODEL; CANDESARTAN;
   PREVENTION; MORBIDITY
AB A linchpin of the cardiometabolic syndrome is insulin resistance, an important cardiovascular and chronic kidney disease risk factor. Activation of the renin-angiotensin-aldosterone system (RAAS) has been shown to impair insulin metabolic signaling and insulin-stimulated glucose uptake as well as pancreatic secretion of insulin. Recent work has highlighted the role of aldosterone as an important component of the RAAS and may play a role in not only altering glucose uptake in skeletal muscle but in normal liver metabolism as well. Like angiotensin II, aldosterone may promote hepatosteatosis and impact pancreatic beta-cells. By blocking the effects of angiotensin II with a RAAS blocker or aldosterone with a mineralocorticoid inhibitor, the effects may be reversed. Therefore, it appears that the RAAS and aldosterone are important in generation of reactive oxygen species in the beta-cell and increased apoptosis. It is clear that preclinical evidence has demonstrated a role for the RAAS and glucose metabolism. While there is sufficient clinical data to support RAAS inhibition with either an angiotensin-converting enzyme inhibitor or an angiotensin receptor blocker, it is important to note none of these studies were powered to address glucose tolerance as a primary end point. Thereby, to complement preclinical studies, more randomized multicenter outcomes evidence is needed to fully elucidate the impact that RAAS inhibition and, specifically, the use of angiotensin receptor blockers have on glucose tolerance. Nonetheless, the weight of evidence suggests that inhibition of the RAAS vs other antihypertensive agents, whether calcium channel blockers, thiazide diuretics, or beta-blockade, improve glucose tolerance.
C1 [Whaley-Connell, Adam] Univ Missouri, Dept Internal Med, Div Nephrol, Columbia, MO 65212 USA.
   [Kurukulasuriya, L. Romayne; Sowers, James R.] Univ Missouri, Dept Internal Med, Div Endocrinol, Columbia, MO 65212 USA.
   [Whaley-Connell, Adam; Sowers, James R.] Harry S Truman VA Med Ctr, Columbia, MO USA.
C3 University of Missouri System; University of Missouri Columbia;
   University of Missouri System; University of Missouri Columbia; US
   Department of Veterans Affairs; Veterans Health Administration (VHA);
   Harry S. Truman Memorial Veterans' Hospital
RP Sowers, JR (corresponding author), Univ Missouri, Dept Internal Med, Div Nephrol, D109 Diabet Ctr HSC,1 Hosp Dr, Columbia, MO 65212 USA.
EM sowersj@health.missouri.edu
OI Whaley-Connell, Adam/0000-0001-8955-5560
FU Novartis and Forest Pharmaceutical; Daiichi Sankyo, Inc.
FX Dr Sowers discloses consulting and receipt of research support from
   Novartis and Forest Pharmaceutical. Dr Whaley-Connell discloses
   Speakers' Bureau for Novartis. Dr. Kurukulasuriya has nothing to
   disclose. The authors acknowledge the assistance of Practicum
   Educational Services in preparing this article and styling the paper for
   journal submission. Editorial support was provided by Robert E. Lamb,
   PharmD, and funded by Daiichi Sankyo, Inc. The authors received an
   honorarium from Daiichi Sankyo, Inc, for time and effort spent preparing
   this article.
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NR 44
TC 0
Z9 0
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1524-6175
EI 1751-7176
J9 J CLIN HYPERTENS
JI J. Clin. Hypertens.
PD DEC
PY 2009
VL 11
IS 12
SU 1
BP S40
EP S47
DI 10.1111/j.1751-7176.2009.00213.x
PG 8
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 522BZ
UT WOS:000271974000008
OA Bronze, Green Accepted
DA 2025-06-11
ER

PT J
AU Liang, J
   Xue, Y
   Zou, CY
   Zhang, T
   Song, HD
   Qi, L
AF Liang, Jun
   Xue, Ying
   Zou, Caiyan
   Zhang, Tong
   Song, Huaidong
   Qi, Lu
TI Serum uric acid and prehypertension among Chinese adults
SO JOURNAL OF HYPERTENSION
LA English
DT Article
DE age; fasting glucose; prehypertension; uric acid
ID CARDIOVASCULAR-DISEASE RISK; MUSCLE-CELL-PROLIFERATION;
   CORONARY-HEART-DISEASE; METABOLIC SYNDROME; ESSENTIAL-HYPERTENSION;
   BLOOD-PRESSURE; INDEPENDENT MECHANISM; INCIDENT HYPERTENSION; OXIDATIVE
   STRESS; US ADULTS
AB Background Raised blood pressure is emerging as an independent risk factor for cardiovascular diseases and diabetes. We examined the relation between serum uric acid and prehypertension and the modification effects of age, obesity, fasting glucose, and lipids in Chinese adults.
   Methods The study samples are from a community-based health examination survey in China. A total of 14451 patients with normal range of blood pressure were included.
   Results The odds ratios [ORs, 95% confidence interval (CI)] of prehypertension across increasing quintiles of serum uric acid were 1.00, 1.04 (0.92-1.18), 1.21 (1.06-1.38), 1.26 (1.09-1.45), and 1.36 (1.17-1.58) (P for trend<0.0001), adjusting for age, sex, body mass index, glucose, and lipids. The regression splines suggested a possible threshold effect for serum uric acid of approximately 200 mu mol/l on prehypertension risk. The associations were significant in both men and women, but was not significant in older individuals aged above 60 years. In addition, fasting glucose significantly interacted with uric acid (P for interaction<0.0001). The associations were more evident in patients with low (P=0.0005) and median glucose levels (P=0.002) than in those with high glucose levels.
   Conclusions Serum uric acid was associated with prehypertension, independent of metabolic risk factors. The associations were not significant in old individuals. Fasting glucose may modify the associations. J Hypertens 27:1761-1765 (C) 2009 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
C1 [Qi, Lu] Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA.
   [Liang, Jun; Xue, Ying; Zou, Caiyan; Zhang, Tong] Southeast Univ, Affiliated Hosp, XuZhou Clin Sch, Xuzhou Med Coll,Cent Hosp Xuzhou,Dept Endocrinol, Xuzhou, Jiangsu, Peoples R China.
   [Song, Huaidong] Shanghai Jiao Tong Univ, Sch Med, Shanghai Inst Endocrinol, Mol Med Ctr,State Key Lab Med Genom,Ruijin Hosp, Shanghai 200030, Peoples R China.
   [Qi, Lu] Harvard Univ, Sch Med, Boston, MA 02115 USA.
   [Qi, Lu] Brigham & Womens Hosp, Dept Med, Channing Lab, Boston, MA USA.
C3 Harvard University; Harvard T.H. Chan School of Public Health; Xuzhou
   Medical University; Southeast University - China; Chinese Academy of
   Sciences; Shanghai Jiao Tong University; Harvard University; Harvard
   Medical School; Harvard University; Harvard University Medical
   Affiliates; Brigham & Women's Hospital
RP Qi, L (corresponding author), Harvard Univ, Sch Publ Hlth, Dept Nutr, 665 Huntington Ave, Boston, MA 02115 USA.
EM nhlqi@channing.harvard.edu
RI Song, Huai-Dong/G-8961-2011
FU NIH [R01 HL071981]; American Heart Association Scientist Development
   Award; Boston Obesity Nutrition Research Center [DK46200]
FX L. Q.' s research is supported by NIH R01 HL071981, the American Heart
   Association Scientist Development Award, and the Boston Obesity
   Nutrition Research Center (DK46200).
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NR 34
TC 37
Z9 42
U1 0
U2 10
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0263-6352
EI 1473-5598
J9 J HYPERTENS
JI J. Hypertens.
PD SEP
PY 2009
VL 27
IS 9
BP 1761
EP 1765
DI 10.1097/HJH.0b013e32832e0b44
PG 5
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 491AP
UT WOS:000269549500007
PM 19512942
DA 2025-06-11
ER

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   LagioU, P
   Trichopouios, D
   Bueno-De-Mesquita, HB
   van Duijnhoven, FJB
   Peeters, PHM
   Slimani, N
   Ferrari, P
   Byrnes, GB
   Riboli, E
   Kaaks, R
AF Rinaldi, Sabina
   Rohrmann, Sabine
   Jenab, Mazda
   Biessy, Carine
   Sieri, Sabina
   Palli, Domenico
   Tumino, Rosario
   Mattiello, Amalla
   Vineis, Paolo
   Nieters, Alexandra
   Linseisen, Jakob
   Pischon, Tobias
   Boeing, Heiner
   Hallmans, Gran
   Palmqvist, Richard
   Manjer, Jonas
   Wirfaelt, Elisabet
   Crowe, Francesca L.
   Khaw, Kay-Tee T.
   Bingham, Sheila
   Tjonneland, Anne
   Olsen, Anja
   Overvad, Kim
   Lund, Eiliv
   Skeie, Guri
   Clavel-Chapelon, Francoise
   Boutron-Ruault, Marie-Christine
   de lauzon-Guillain, Blandine
   Ardanaz, Eva
   Jakszyn, Paula
   Quiros, Jose Ramon
   Chirlaque, Maria-Dolores
   Sanchez, Maria-Jose
   Dorronsoro, Miren
   Trichopoulou, Antonia
   LagioU, Pagona
   Trichopouios, Dimitrious
   Bueno-De-Mesquita, H. Bas
   van Duijnhoven, Franzel J. B.
   Peeters, Petra H. M.
   Slimani, Nadia
   Ferrari, Pietro
   Byrnes, Graham B.
   Riboli, Elio
   Kaaks, Rudolf
TI Glycosylated Hemoglobin and Risk of Colorectal Cancer in Men and Women,
   the European Prospective Investigation into Cancer and Nutrition
SO CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
LA English
DT Article
ID CHRONIC OXIDATIVE STRESS; BETA-CELL FUNCTION; SERUM C-PEPTIDE;
   DIABETES-MELLITUS; INSULIN-RESISTANCE; METABOLIC SYNDROME; GLUCOSE
   TOXICITY; RECTAL CANCERS; COLON-CANCER; FATTY-ACIDS
AB Although large-scale prospective cohort studies have related hyperglycemia to increased risk of cancer overall, studies specifically on colorectal cancer have been generally small. We investigated the association between prediagnostic levels of glycosylated hemoglobin (HbA1c), a marker for average glucose level in blood, and colorectal cancer risk in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition cohort. One thousand and twenty-six incident colorectal cancer cases (561 men and 465 women) and 1,026 matched controls were eligible for the study. Multivariate conditional logistic regression was used to estimate odds ratios (ORS) adjusted for possible confounders. Increasing HbA1c percentages were statistically significantly associated with a mild increase in colorectal cancer risk in the whole population [OR, 1.10; 95% confidence interval (CI), 1.01,1.19 for a 10% increase in HbA1c]. In women, increasing HbA1c percentages were associated with a statistically significant increase in colorectal cancer risk (OR, 1.16; 95% CI, 1.01, 1.32 for a 10% increase in HbA1c) and with a borderline statistically significant increase in rectum cancer (OR, 1.22; 95% CI, 0.99,1.50 for a 10% increase in HbA1c). No significant association with cancer risk was observed in men. The results of the current study suggest a mild implication of hyperglycemia in colorectal cancer, which seems more important in women than in men, and more for cancer of the rectum than of the colon. (Cancer Epidemiol Biomarkers Prev 2008;17(11):3108-15)
C1 [Rinaldi, Sabina; Slimani, Nadia; Ferrari, Pietro; Byrnes, Graham B.] Int Agcy Res Canc, F-69372 Lyon 08, France.
   [Rohrmann, Sabine; Nieters, Alexandra; Linseisen, Jakob; Kaaks, Rudolf] German Canc Res Ctr, Div Canc Epidemiol, D-6900 Heidelberg, Germany.
   [Sieri, Sabina] Natl Canc Inst, Epidemiol Unit, I-20133 Milan, Italy.
   [Palli, Domenico] CSPO Sci Inst Tuscany, Mol & Nutrit Epidemiol Unit, Florence, Italy.
   [Tumino, Rosario] Azienda Ospedal Civile MPArezzo, Canc Registry, Ragusa, Italy.
   [Mattiello, Amalla] Univ Naples Federico II, Dipartimento Med Clin & Sperimentale, Naples, Italy.
   [Riboli, Elio] Univ London Imperial Coll Sci Technol & Med, Publ Hlth & Primary Care Fac Med, Div Epidemiol, London, England.
   [Pischon, Tobias; Boeing, Heiner] German Inst Human Nutr, Dept Epidemiol, Potsdam, Germany.
   [Palmqvist, Richard] Umea Univ Hosp, Dept Med Biosci, S-90185 Umea, Sweden.
   [Manjer, Jonas] Malmo Univ Hosp, Dept Surg, Malmo, Sweden.
   [Wirfaelt, Elisabet] Lund Univ, Dept Clin Sci Malm Nutr Epidemiol, Lund, Sweden.
   [Crowe, Francesca L.] Univ Oxford, Canc Res UK Epidemiol Unit, Oxford, England.
   [Khaw, Kay-Tee T.] Addenbrookes Hosp, Clin Gerontol Unit, Cambridge, England.
   [Bingham, Sheila] MRC Dunn Human Nutr Unit, Cambridge, England.
   [Bingham, Sheila] Univ Cambridge, Dept Publ Hlth & Primary Care, MRC Ctr Nutr Epidemiol Canc Prevent & Survival, Cambridge, England.
   [Tjonneland, Anne; Olsen, Anja] Danish Canc Soc, Inst Canc Epidemiol, Copenhagen, Denmark.
   [Overvad, Kim] Aarhus Univ Hosp, Dept Clin Epidemiol, DK-8000 Aarhus, Denmark.
   [Lund, Eiliv; Skeie, Guri] Univ Tromso, Inst Community Med, Tromso, Norway.
   [Clavel-Chapelon, Francoise; Boutron-Ruault, Marie-Christine; de lauzon-Guillain, Blandine] Univ Paris Sud, INSERM, ERI 20,EA 4045,IFR 69, Inst Gustave Roussy, Villejuif, France.
   [Ardanaz, Eva] Publ Hlth Inst Navarra Pamplona, Pamplona, Spain.
   [Ardanaz, Eva] CIBERESP, Pamplona, Spain.
   [Jakszyn, Paula] Catalan Inst Oncol, Dept Epidemiol, Barcelona, Spain.
   [Quiros, Jose Ramon] Consejeria Salue & Serv Sanit, Asturias, Spain.
   [Chirlaque, Maria-Dolores] CIBERESP, Murcia Hlth Council, Dept Epidemiol, Murcia, Spain.
   [Sanchez, Maria-Jose] Andalusian Sch Publ Hlth, Granada, Spain.
   [Sanchez, Maria-Jose] CIBERESP, Granada, Spain.
   [Trichopoulou, Antonia; LagioU, Pagona; Trichopouios, Dimitrious] Univ Athens, Sch Med, Dept Hyg & Epidemiol, GR-11527 Athens, Greece.
   [Bueno-De-Mesquita, H. Bas; van Duijnhoven, Franzel J. B.] Natl Inst Publ Hlth & Environm, RIVM, NL-3720 BA Bilthoven, Netherlands.
   [Peeters, Petra H. M.] Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands.
C3 World Health Organization; International Agency for Research on Cancer
   (IARC); Helmholtz Association; German Cancer Research Center (DKFZ);
   Fondazione IRCCS Istituto Nazionale Tumori Milan; Civile M.P. Arezzo
   Hospital; University of Naples Federico II; Imperial College London;
   Leibniz Association; Deutsches Institut fur Ernahrungsforschung
   Potsdam-Rehbrucke (DIfE); Umea University; Umea University Hospital;
   Lund University; Skane University Hospital; Lund University; Cancer
   Research UK; University of Oxford; Cambridge University Hospitals NHS
   Foundation Trust; Addenbrooke's Hospital; University of Cambridge; UK
   Research & Innovation (UKRI); Medical Research Council UK (MRC); MRC
   Human Nutrition Research; University of Cambridge; Danish Cancer
   Society; Aarhus University; UiT The Arctic University of Tromso;
   Institut National de la Sante et de la Recherche Medicale (Inserm);
   Universite Paris Saclay; UNICANCER; Gustave Roussy; Public Health
   Institute of Navarra; CIBER - Centro de Investigacion Biomedica en Red;
   CIBERESP; Institut Catala d'Oncologia; Murcia Regional Health Council;
   CIBER - Centro de Investigacion Biomedica en Red; CIBERESP; Escuela
   Andaluza de Salud Publica; CIBER - Centro de Investigacion Biomedica en
   Red; CIBERESP; Athens Medical School; National & Kapodistrian University
   of Athens; Netherlands National Institute for Public Health & the
   Environment; Utrecht University; Utrecht University Medical Center
RP Rinaldi, S (corresponding author), Int Agcy Res Canc, 150 Cours Albert Thomas, F-69372 Lyon 08, France.
EM Rinaldi@iarc.fr
RI TRICHOPOULOU, ANTONIA/ABF-8727-2021; Khaw, Kay-Tee/AAZ-3209-2021;
   Pischon, Tobias/HGE-8577-2022; Chirlaque, Maria-Dolores/KCL-3322-2024;
   Boutron-Ruault, Marie-Christine/H-3936-2014; Sánchez,
   María/HOC-7747-2023; Tjonneland, Anne/AGU-0320-2022; Riboli,
   Elio/A-4357-2009; van Duijnhoven, Fränzel/GWC-0059-2022;
   Clavel-Chapelon, Francoise/G-6733-2014; Jenab, Mehdi/L-2515-2019;
   Rohrmann, Sabine/D-2113-2012; Jakszyn, Paula/K-1458-2016; SANCHEZ-PEREZ,
   MARIA JOSE/D-1087-2011; Mattiello, Amalia/K-5112-2016; Linseisen,
   Jakob/B-5353-2014; Sieri, Sabina/K-4667-2016; de Lauzon-Guillain,
   Blandine/P-4659-2016
OI Crowe, Francesca/0000-0003-4026-1726; Jakszyn,
   Paula/0000-0003-0672-8847; Riboli, Elio/0000-0001-6795-6080; tumino,
   rosario/0000-0003-2666-414X; Tjonneland, Anne/0000-0003-4385-2097;
   PALLI, Domenico/0000-0002-5558-2437; SANCHEZ-PEREZ, MARIA
   JOSE/0000-0003-4817-0757; Overvad, Kim/0000-0001-6429-7921; Byrnes,
   Graham/0000-0003-3893-7539; Mattiello, Amalia/0000-0003-3676-7353;
   Ardanaz, Eva/0000-0001-8434-2013; Skeie, Guri/0000-0003-2476-4251;
   Linseisen, Jakob/0000-0002-9386-382X; Sieri, Sabina/0000-0001-5201-172X;
   Olsen, Anja/0000-0003-4788-503X; Jenab, Mazda/0000-0002-0573-1852;
   Pischon, Tobias/0000-0003-1568-767X; de Lauzon-Guillain,
   Blandine/0000-0001-5887-8842; Lund, Eiliv/0000-0002-8071-8711; Rohrmann,
   Sabine/0000-0002-2215-1200
FU British Heart Foundation Funding Source: Medline; Cancer Research UK
   Funding Source: Medline; Medical Research Council [G0401527] Funding
   Source: Medline; NCI NIH HHS [1R01CA102460] Funding Source: Medline;
   Wellcome Trust Funding Source: Medline; Department of Health Funding
   Source: Medline; Associazione Italiana per la Ricerca sul Cancro Funding
   Source: Custom
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NR 51
TC 64
Z9 68
U1 0
U2 10
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 1055-9965
EI 1538-7755
J9 CANCER EPIDEM BIOMAR
JI Cancer Epidemiol. Biomarkers Prev.
PD NOV
PY 2008
VL 17
IS 11
BP 3108
EP 3115
DI 10.1158/1055-9965.EPI-08-0495
PG 8
WC Oncology; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Public, Environmental & Occupational Health
GA 372IY
UT WOS:000260896500028
PM 18990751
DA 2025-06-11
ER

PT J
AU Otsuka, R
   Tamakoshi, K
   Wada, K
   Matsushita, K
   Ouyang, P
   Hotta, Y
   Takefuji, S
   Mitsuhashi, H
   Toyoshima, H
   Shimokata, H
   Yatsuya, H
AF Otsuka, Rei
   Tamakoshi, Koji
   Wada, Keiko
   Matsushita, Kunihiro
   Ouyang, Pei
   Hotta, Yo
   Takefuji, Seiko
   Mitsuhashi, Hirotsugu
   Toyoshima, Hideaki
   Shimokata, Hiroshi
   Yatsuya, Hiroshi
TI Having more healthy practice was associated with low white blood cell
   counts in middle-aged Japanese male and female workers
SO INDUSTRIAL HEALTH
LA English
DT Article
DE white blood cell; healthy practice; cross-sectional study;
   questionnaire; epidemiology; Japanese
ID CARDIOVASCULAR RISK-FACTORS; CORONARY-HEART-DISEASE; MALE OFFICE
   WORKERS; ALCOHOL-CONSUMPTION; METABOLIC SYNDROME; PHYSICAL-ACTIVITY;
   LEUKOCYTE COUNT; INFLAMMATION; SMOKING; MARKERS
AB White blood cell (WBC) count is well known to be an independent risk marker for cardiovascular disease. The aim of this study is to examine the relationships of WBC counts to seven health practices including obesity, eating habits, smoking, alcohol intake, sleeping, physical activity, and perceived mental stress, and then clustering the relevant healthy practices. The subjects were 1,492 male and 316 female Japanese workers aged 40 yr and over in 2002. Each of seven health practices from a self-administered questionnaire was categorized as a 'healthy' or 'unhealthv' practice, and WBC counts from fasting blood samples were determined by automated particle counters. The means of age and WBC counts were 49.5 yr and 5,375 cells/mu l in men, and 48.6 yr and 4,890 cells/mu l in women, respectively. After multivariate adjustments for all health practices and age, the estimated WBC counts were significantly lower in normal weight subjects and never or former smokers (p<0.01). Age-adjusted WBC counts decreased significantly by 204.9 +/- 23.7 cells/mu l (means +/- SE) and 117.6 +/- 53.2 cells/mu l for each increase in one healthy practice (p<0.05), respectively, suggesting that cultivating healthier practices would lead to lower WBC counts. This study recommends modifying unhealthy practice one by one and maintaining healthy practices as an effective strategy for the prevention of atherosclerotic diseases, in addition, to quit smoking or abstain from heavy smoking especially in men is important to prevent the low-grade inflammation.
C1 [Otsuka, Rei; Tamakoshi, Koji; Wada, Keiko; Matsushita, Kunihiro; Ouyang, Pei; Hotta, Yo; Takefuji, Seiko; Mitsuhashi, Hirotsugu; Toyoshima, Hideaki; Yatsuya, Hiroshi] Nagoya Univ, Grad Sch Med, Dept Publ Hlth Hlth Informat Dynam Field Social L, Showa Ku, Nagoya, Aichi 4668550, Japan.
   [Otsuka, Rei; Shimokata, Hiroshi] Natl Ctr Geriatr & Gerontol, Natl Inst Longev Sci, Dept Epidemiol, Obu, Japan.
   [Matsushita, Kunihiro; Mitsuhashi, Hirotsugu] Nagoya Univ, Grad Sch Med, Dept Cardiol, Nagoya, Aichi 4648601, Japan.
   [Hotta, Yo; Takefuji, Seiko] Nagoya Univ, Grad Sch Med, Dept Metab Dis, Nagoya, Aichi 4648601, Japan.
   [Toyoshima, Hideaki] Anjo Kosei Hosp, Hlth Care Ctr, Aichi, Japan.
C3 Nagoya University; National Center for Geriatrics & Gerontology; Nagoya
   University; Nagoya University
RP Otsuka, R (corresponding author), Nagoya Univ, Grad Sch Med, Dept Publ Hlth Hlth Informat Dynam Field Social L, Showa Ku, 65 Tsurumai, Nagoya, Aichi 4668550, Japan.
RI Yatsuya, Hiroshi/L-4213-2016; Matsushita, Kunihiro/AAJ-5817-2020;
   OUYANG, PEI/JJE-8292-2023
OI Yatsuya, Hiroshi/0000-0002-6220-9251
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NR 21
TC 6
Z9 6
U1 1
U2 2
PU NATL INST OCCUPATIONAL SAFETY & HEALTH, JAPAN
PI KAWASAKI KANAGAWA
PA 21-1 NAGAO 6-CHOME TAMA-KU, KAWASAKI KANAGAWA, 214, JAPAN
SN 0019-8366
J9 IND HEALTH
JI Ind. Health
PD JUL
PY 2008
VL 46
IS 4
BP 341
EP 347
DI 10.2486/indhealth.46.341
PG 7
WC Environmental Sciences; Public, Environmental & Occupational Health;
   Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health; Toxicology
GA 332PU
UT WOS:000258096400006
PM 18716382
OA Bronze
DA 2025-06-11
ER

PT J
AU Groop, PH
   Forsblom, C
   Thomas, MC
AF Groop, PH
   Forsblom, C
   Thomas, MC
TI Mechanisms of disease: pathway-selective insulin resistance and
   microvascular complications of diabetes
SO NATURE CLINICAL PRACTICE ENDOCRINOLOGY & METABOLISM
LA English
DT Review
DE diabetes; endothelial dysfunction; insulin resistance; insulin
   signaling; microvascular complications
ID PROTEIN-KINASE-C; POLYCYSTIC-OVARY-SYNDROME; ENDOTHELIAL GROWTH-FACTOR;
   SMOOTH-MUSCLE-CELLS; NITRIC-OXIDE; PERIPHERAL NEUROPATHY; METABOLIC
   SYNDROME; SKELETAL-MUSCLE; BLOOD-PRESSURE; HIGH GLUCOSE
AB Resistance to the actions of insulin is strongly associated with teh microvascular complications of diabetes. To the extent that insulin resistance leads to hyperglycemia, dyslipidemia and hypertension, this association is not surprising. It is now clear that insulin also has direct actions in the microvasculature that influence the development and progression of microvascular disease. In the healthy state, insulin appears to have only minor effects on vascular function, because of the activation of opposing mediators such as nitric oxide and endothelin-1. Diabetes and obesity, however, are associated with selective insulin resistance in the physophatidylinositol-3-kinase signaling pathway, which leads to reduced synthesis of nitric oxide, impaired metabolic control and compensatory hyperinsulinemia. By contrast, insulin signaling via extracellular signal-regulated kinase dependent pathways is relatively unaffected in diabetes, tipping the balance of insulin's actions so that they favor abnormal vasoreactivity, angiogenesis, and other pathways implicated in microvascular complications and hypertension. In addition, preferential impairment of nonoxidative glucose metabolism leads to increased intracellular formation of advantaged glycation end products, oxidative stress and activation of other pathogenic mediators. Despite a strong temporal association, a causal link between pathway-selective insulin resistance and microvascular damage remains to be established. It is possible that this association reflects a common genotype or phenotype. Nonetheless, insulin resistance remains an important marker of risk a key target for intervention, because those patients who achieve a greater improvement of insulin sensitivity achieve better microvascular outcomes.
C1 Univ Helsinki, Folhalsen Res Ctr, Biomed Helsinki, FIN-00014 Helsinki, Finland.
   Univ Helsinki, Cent Hosp, FIN-00014 Helsinki, Finland.
   Monash Univ, Melbourne, Vic 3004, Australia.
C3 Folkhalsan Research Center; University of Helsinki; University of
   Helsinki; Helsinki University Central Hospital; Monash University
RP Groop, PH (corresponding author), Univ Helsinki, Folhalsen Res Ctr, Biomed Helsinki, POB 63,Haartmaninkatu 8, FIN-00014 Helsinki, Finland.
EM per-henrik.groop@helsinki.fi
RI Thomas, María/D-9065-2016
OI Thomas, Merlin/0000-0003-0694-8743; Groop,
   Per-Henrik/0000-0003-4055-6954
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NR 78
TC 153
Z9 172
U1 1
U2 20
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 1745-8366
J9 NAT CLIN PRACT ENDOC
JI Nat. Clin. Pract. Endocrinol. Metab.
PD DEC
PY 2005
VL 1
IS 2
BP 100
EP 110
DI 10.1038/ncpendmet0046
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 010DB
UT WOS:000235166000006
PM 16929378
DA 2025-06-11
ER

PT J
AU Eromosele, OB
   Shapira-Daniels, A
   Yuan, A
   Lukan, A
   Akinrimisi, O
   Chukwurah, M
   Nayor, M
   Benjamin, EJ
   Lin, HH
AF Eromosele, Oseiwe B.
   Shapira-Daniels, Ayelet
   Yuan, Amy
   Lukan, Abdulkareem
   Akinrimisi, Olumuyiwa
   Chukwurah, Marius
   Nayor, Matthew
   Benjamin, Emelia J.
   Lin, Honghuang
TI The association of exhaled carbon monoxide with atrial fibrillation and
   left atrial size in the Framingham Heart Study
SO AMERICAN HEART JOURNAL PLUS: CARDIOLOGY RESEARCH AND PRACTICE
LA English
DT Article
DE Atrial fibrillation; Exhaled carbon monoxide; Left atrial size
ID LONG-TERM TRENDS; CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; OXIDATIVE
   STRESS; HEME OXYGENASE-1; NITRIC-OXIDE; RISK-FACTORS; EXPOSURE;
   PREDICTION; MORTALITY
AB Background: Exhaled carbon monoxide (eCO) is associated with subclinical and overt cardiovascular disease and stroke. The association between eCO with left atrial size, prevalent, or incident atrial fibrillation (AF) are uncertain. Methods: eCO was measured using an Ecolyzer instrument among Framingham Heart Study Offspring and Omni participants who attended an examination from 1994 to 1998. We analyzed multivariable-adjusted (current smoking, and other covariates including age, race, sex, height, weight, systolic blood pressure, diastolic blood pressure, diabetes, hypertension treatment, prevalent myocardial infarction [MI], and prevalent heart failure [HF]). Cox and logistic regression models assessed the relations between eCO and incident AF (primary model), and prevalent AF and left atrial (LA) size (pre-specified secondary analyses). We also conducted secondary analyses adjusting for biomarkers, and interim MI and interim HF. Results: Our study sample included 3814 participants (mean age 58 +/- 10 years; 54.4 % women, 88.4 % White). During an average of 18.8 +/- 6.5 years follow-up, 683 participants were diagnosed with AF. eCO was associated with incident AF after adjusting for established AF risk factors (HR, 1.31 [95 % CI, 1.09-1.58]). In secondary analyses the association remained significant after additionally adjusting for C-reactive protein and B-type natriuretic peptide, and interim MI and CHF, and in analyses excluding individuals who currently smoked. eCO was not significantly associated with LA size and prevalent AF. Conclusion: In our community-based sample of individuals without AF, higher mean eCO concentrations were associated with incident AF. Further investigation is needed to explore the biological mechanisms linking eCO with AF.
C1 [Eromosele, Oseiwe B.; Shapira-Daniels, Ayelet; Yuan, Amy; Nayor, Matthew; Benjamin, Emelia J.] Boston Univ, Boston Med Ctr, Chobanian & Avedisian Sch Med, Dept Med, Boston, MA 02118 USA.
   [Lukan, Abdulkareem] Advocate Illinois Masonic Med Ctr, Dept Med, Chicago, IL 60657 USA.
   [Akinrimisi, Olumuyiwa] Stanford Univ, Dept Med, Sch Med, Palo Alto, CA 94305 USA.
   [Chukwurah, Marius] Hosp Univ Penn, Dept Med, Div Cardiol, Philadelphia, PA USA.
   [Benjamin, Emelia J.] Boston Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02118 USA.
   [Benjamin, Emelia J.; Lin, Honghuang] Univ Massachusetts, Dept Med, Chan Med Sch, 55 Lake Ave North,S6-755, Worcester, MA 01655 USA.
   [Lin, Honghuang] Boston Univ, Boston, MA USA.
   [Lin, Honghuang] NHLBI, Framingham Heart Study, Framingham, MA USA.
C3 Boston Medical Center; Boston University; Stanford University;
   University of Pennsylvania; Boston University; University of
   Massachusetts System; UMass Chan Medical School; University of
   Massachusetts Worcester; Boston University; National Institutes of
   Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI);
   Framingham Heart Study
RP Lin, HH (corresponding author), Univ Massachusetts, Dept Med, Chan Med Sch, 55 Lake Ave North,S6-755, Worcester, MA 01655 USA.
EM Honghuang.Lin@umassmed.edu
RI Nayor, Matthew/IAQ-0421-2023; Lin, Honghuang/A-3269-2019
FU National Heart, Blood, and Lung Institute [75N92019D00031]; National
   Institutes of Health [R01HL126911, R01HL092577, R01 R01AG066010,
   18SFRN34110082, U54HL120163, U01AG068221]
FX The Framingham Heart Study is supported by a contract from the National
   Heart, Blood, and Lung Institute: 75N92019D00031. The investigators were
   supported by the following National Institutes of Health grants:
   R01HL126911 (EJB) , R01HL092577 (EJB) , R01 R01AG066010 (EJB) ,
   18SFRN34110082 (EJB) , U54HL120163 (EJB) , and U01AG068221 (HL) . The
   funding agencies had no role in study design, data collection and
   analysis, decision to publish, or preparation of the manuscript.
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NR 53
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
EI 2666-6022
J9 AM HEART J PLUS
JI Am. Heart J. Plus-Cardiol. Res. Pract.
PD SEP
PY 2024
VL 45
AR 100439
DI 10.1016/j.ahjo.2024.100439
EA AUG 2024
PG 6
WC Cardiac & Cardiovascular Systems
WE Emerging Sources Citation Index (ESCI)
SC Cardiovascular System & Cardiology
GA D4A1V
UT WOS:001295619200001
PM 39234302
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Hezam, AAM
   Shaghdar, HBM
   Chen, LY
AF Hezam, Ali Ahmed Mohammed
   Shaghdar, Hanan Basheer Mohammed
   Chen, Liying
TI The connection between hypertension and diabetes and their role in heart
   and kidney disease development
SO JOURNAL OF RESEARCH IN MEDICAL SCIENCES
LA English
DT Review
DE Blood pressure; cardiovascular disease; coronary heart disease;
   diabetes; guidelines; hypertension; interaction; stroke
ID CONVERTING ENZYME-INHIBITORS; PERIPHERAL ARTERY-DISEASE; SYSTOLIC
   BLOOD-PRESSURE; STAGE RENAL-DISEASE; CARDIOVASCULAR-DISEASE; ORTHOSTATIC
   HYPOTENSION; METABOLIC SYNDROME; RISK; EPIDEMIOLOGY; PREVALENCE
AB Hypertension and diabetes are two common metabolic disorders that often coexist in the same individual. Their concurrence increases the risk of cardiovascular disease, renal dysfunction, and other complications. Cardiovascular disease is the primary cause of morbidity and mortality in individuals with diabetes, and hypertension further aggravates this condition. Interestingly, hypertension and diabetes share several common pathophysiological mechanisms including insulin resistance, vascular inflammation, endothelial dysfunction, obesity, and oxidative stress suggesting a cross-talk between these two conditions that could potentially contribute to the development of other human diseases. Effective management of diabetes should include a multifaceted approach that addresses not only glycemic control but also blood pressure (BP) and lipid control. Treatment plans should be individualized to each patient's needs and should involve a combination of lifestyle modifications and medications to achieve optimal control. With the availability of newer antidiabetic medications such as SGLT inhibitors and GLP1 receptor agonists, it is crucial to consider their potential to reduce BP, enhance kidney function, and lower the risk of cardiovascular diseases when initiating treatment for glycemic control. A more profound comprehension of the shared underlying mechanisms between these conditions could pave the way for the development of innovative therapeutic approaches to tackle them. Our review offers an in-depth analysis of the literature, providing a holistic view of the mechanisms underlying diabetes-hypertension comorbidity and its implications on heart and kidney diseases. The present article concludes by discussing current approaches for managing hypertensive diabetic patients to create a set of comprehensive individualized recommendations.
C1 [Hezam, Ali Ahmed Mohammed; Chen, Liying] Zhejiang Univ, Sir Run Run Shaw Hosp, Sch Med, Dept Gen Practice, 3 Qingchun East Rd, Hangzhou 310016, Peoples R China.
   [Shaghdar, Hanan Basheer Mohammed; Chen, Liying] Zhejiang Univ, Sch Med, Hangzhou, Zhejiang, Peoples R China.
C3 Zhejiang University; Zhejiang University
RP Chen, LY (corresponding author), Zhejiang Univ, Sir Run Run Shaw Hosp, Sch Med, Dept Gen Practice, 3 Qingchun East Rd, Hangzhou 310016, Peoples R China.
EM 3197020@zju.edu.cn
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NR 115
TC 7
Z9 7
U1 1
U2 2
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, Maharashtra, INDIA
SN 1735-1995
EI 1735-7136
J9 J RES MED SCI
JI J. Res. Med. Sci.
PD APR
PY 2024
VL 29
IS 1
AR 22
DI 10.4103/jrms.jrms_470_23
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA YJ8N4
UT WOS:001268214300001
PM 38855561
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Arslanca, SB
   Caglar, AT
AF Arslanca, Seyma Banu
   Caglar, Ali Turhan
TI Comprehensive analysis of macrosomia: exploring the association between
   first-trimester alanine aminotransferase and uric acid measurements in
   pregnant women
SO JOURNAL OF PERINATAL MEDICINE
LA English
DT Article
DE alanine aminotransferase; macrosomia; non-alcoholic fatty liver disease;
   uric acid
ID FATTY LIVER-DISEASE; GESTATIONAL DIABETES-MELLITUS; OXIDATIVE STRESS;
   RISK; LEVEL
AB Objectives: Investigating the relationship between liver enzymes, uric acid (UA), and macrosomia will benefit physicians in the early detection of complications that may emerge during/after pregnancy. The study analyzed liver enzyme activity and UA levels in first-trimester pregnant for the risk of macrosomia.Methods: This retrospective cross-sectional research analyzed the data of pregnant women who gave birth between Jan 2021-2023. All data were extracted from medical records, and UA and AST-ALT were examined in all the participants.Results: Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels were higher in the macrosomia (p<0.05). Similarly, UA levels were higher in the macrosomia (p<0.001). There was a moderate positive correlation between ALT and birth weight (r=0.168, p<0.01), while we found a strong positive correlation between UA and birth weight (r=0.355, p<0.01). In the ROC (receiver operating characteristic), Area Under the Curve (AUC) for ALT and UA was significant (p<0.0001) but not for AST (p=0.157). UA showed a predictive value for macrosomia with 68.1 % sensitivity and 63.8 % specificity at a 3.15 cut-off (AUC:0.689; p:0.0001; CI:0.644-0.725).Conclusions: These results indicate that ALT and UA may be potentially important in determining the risk of macrosomia. The UA had a more potent marker for macrosomia than ALT. The occurrence of macrosomia might be more closely related to the mother's metabolic syndrome rather than NAFLD.
C1 [Caglar, Ali Turhan] Etlik City Hosp, Dept Perinatol, TR-06170 Ankara, Turkiye.
   [Arslanca, Seyma Banu] Etlik City Hosp, Dept Perinatol, Ankara, Turkiye.
RP Caglar, AT (corresponding author), Etlik City Hosp, Dept Perinatol, TR-06170 Ankara, Turkiye.
EM dr.banubozkurt@hotmail.com; turhan_caglar@yahoo.com
RI Arslanca, S. Banu/HPG-4722-2023
OI Arslanca, S. Banu/0000-0003-2494-3372; caglar, ali
   turhan/0000-0002-7022-3029
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NR 27
TC 1
Z9 1
U1 0
U2 1
PU WALTER DE GRUYTER GMBH
PI BERLIN
PA GENTHINER STRASSE 13, D-10785 BERLIN, GERMANY
SN 0300-5577
EI 1619-3997
J9 J PERINAT MED
JI J. Perinat. Med.
PD OCT 26
PY 2023
VL 51
IS 8
BP 1040
EP 1045
DI 10.1515/jpm-2023-0199
EA JUL 2023
PG 6
WC Obstetrics & Gynecology; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology; Pediatrics
GA S9YN5
UT WOS:001036212600001
PM 37490106
DA 2025-06-11
ER

PT J
AU Hara, T
   Fukuda, D
   Ganbaatar, B
   Pham, PT
   Aini, K
   Rahadian, A
   Suto, K
   Yagi, S
   Kusunose, K
   Yamada, H
   Soeki, T
   Sata, M
AF Hara, Tomoya
   Fukuda, Daiju
   Ganbaatar, Byambasuren
   Pham, Phuong Tran
   Aini, Kunduziayi
   Rahadian, Arief
   Suto, Kumiko
   Yagi, Shusuke
   Kusunose, Kenya
   Yamada, Hirotsugu
   Soeki, Takeshi
   Sata, Masataka
TI Olive mill wastewater and hydroxytyrosol inhibits atherogenesis in
   apolipoprotein E-deficient mice
SO HEART AND VESSELS
LA English
DT Article
DE Atherosclerosis; Inflammation; Macrophage; Olive polyphenol;
   Hydroxytyrosol
ID MEDITERRANEAN-STYLE DIET; CARDIOVASCULAR-DISEASE; ENDOTHELIAL
   DYSFUNCTION; VASCULAR INFLAMMATION; METABOLIC SYNDROME; OIL;
   ATHEROSCLEROSIS; MACROPHAGES; ACTIVATION; EXPRESSION
AB The Mediterranean diet, which is characterized by high consumption of olive oil, prevents cardiovascular disease. Meanwhile, olive mill wastewater (OMWW), which is obtained as a byproduct during olive oil production, contains various promising bioactive components such as water-soluble polyphenols. Hydroxytyrosol (HT), the major polyphenol in OMWW, has anti-oxidative and anti-inflammatory properties; however, the atheroprotective effects of OMWW and HT remain to be fully understood. Here, we investigated the effect of OMWW and HT on atherogenesis. Male 8-week-old apolipoprotein E-deficient mice were fed a western-type diet supplemented with OMWW (0.30%w/w) or HT (0.02%w/w) for 20 weeks. The control group was fed a non-supplemented diet. OMWW and HT attenuated the development of atherosclerosis in the aortic arch as determined by Sudan IV staining (P < 0.01, respectively) without alteration of body weight, plasma lipid levels, and blood pressure. OMWW and HT also decreased the production of oxidative stress (P < 0.01, respectively) and the expression of NADPH oxidase subunits (e.g., NOX2 and p22phox) and inflammatory molecules (e.g. IL-1 & beta; and MCP-1) in the aorta. The results of in vitro experiments demonstrated that HT inhibited the expression of these molecules that were stimulated with LPS in RAW264.7 cells, murine macrophage-like cells. OMWW and HT similarly attenuated atherogenesis. HT is a major component of water-soluble polyphenols in OMWW, and it inhibited inflammatory activation of macrophages. Therefore, our results suggest that the atheroprotective effects of OMWW are at least partially attributable to the anti-inflammatory effects of HT.
C1 [Hara, Tomoya; Fukuda, Daiju; Ganbaatar, Byambasuren; Pham, Phuong Tran; Aini, Kunduziayi; Rahadian, Arief; Suto, Kumiko; Yagi, Shusuke; Kusunose, Kenya; Sata, Masataka] Tokushima Univ, Dept Cardiovasc Med, Grad Sch Biomed Sci, 3-18-15 Kuramoto Cho, Tokushima 7708503, Japan.
   [Fukuda, Daiju] Tokushima Univ, Dept Cardiodiabet Med, Grad Sch Biomed Sci, Tokushima 7708503, Japan.
   [Yamada, Hirotsugu] Tokushima Univ, Dept Community Med Cardiol, Grad Sch Biomed Sci, Tokushima 7708503, Japan.
   [Soeki, Takeshi] Tokushima Univ, Dept Community Med & Med Sci, Grad Sch Biomed Sci, Tokushima 7708503, Japan.
C3 Tokushima University; Tokushima University; Tokushima University;
   Tokushima University
RP Hara, T (corresponding author), Tokushima Univ, Dept Cardiovasc Med, Grad Sch Biomed Sci, 3-18-15 Kuramoto Cho, Tokushima 7708503, Japan.
EM hara.tomoya.2@tokushima-u.ac.jp
RI FUKUDA, Daiju/LXU-5347-2024; Sata, Masataka/IST-9041-2023; Kusunose,
   Kenya/AAC-9978-2021; Rahadian, Arief/MYS-2317-2025
FU Grants-in-Aid for Scientific Research [23K24330] Funding Source: KAKEN
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NR 58
TC 4
Z9 4
U1 1
U2 1
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0910-8327
EI 1615-2573
J9 HEART VESSELS
JI Heart Vessels
PD NOV
PY 2023
VL 38
IS 11
BP 1386
EP 1394
DI 10.1007/s00380-023-02290-5
EA JUL 2023
PG 9
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA S8IE5
UT WOS:001028828400001
PM 37462755
DA 2025-06-11
ER

PT J
AU Lai, JS
   Yuan, WL
   Ong, CN
   Tan, KH
   Yap, F
   Chong, YS
   Gluckman, PD
   Godfrey, KM
   Lee, YS
   Chan, JKY
   Chan, SY
   Chong, MFF
AF Lai, Jun S.
   Yuan, Wen Lun
   Ong, Choon Nam
   Tan, Kok Hian
   Yap, Fabian
   Chong, Yap Seng
   Gluckman, Peter D.
   Godfrey, Keith M.
   Lee, Yung Seng
   Chan, Jerry K. Y.
   Chan, Shiao-Yng
   Chong, Mary F. F.
TI Perinatal plasma carotenoid and vitamin E concentrations with maternal
   blood pressure during and after pregnancy
SO NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
LA English
DT Article
DE Carotenoids; Vitamin E; Blood pressure; Pregnancy; Post -pregnancy
ID OXIDATIVE STRESS; CARDIOVASCULAR RISK; METABOLIC SYNDROME; DIETARY
   PATTERNS; HYPERTENSION; ASSOCIATION; ANTIOXIDANTS; RETINOL; PROTEIN
AB Background and aims: Few studies examined the influence of carotenoids and vitamin E on blood pressure or hypertension during and after pregnancy. We related perinatal plasma concentrations of carotenoids and vitamin E (in individual forms and in combination) to blood pressure and hypertension at late pregnancy and 4 years post-pregnancy.Methods and results: In 684 women of the Growing Up in Singapore Towards Healthy Outcomes cohort, we quantified plasma carotenoids and vitamin E concentrations at delivery. Systolic blood pressure and diastolic blood pressure (SBP and DBP) around 37-39 weeks' gestation were extracted from obstetric records and measured at 4 years post-pregnancy. Principal component analysis derived patterns of carotenoids (CP) and vitamin E. Associations were examined using linear or logistic regressions adjusting for confounders. Two carotenoids (CP1: a-carotene, 0 -carotene, and lutein; CP2: zeaxanthin, lycopene, and 0-cryptoxanthin) and one vitamin E (g-, d-, and a-tocopherols) patterns were derived. CP1 (1SD score increment) was associated with lower SBP and DBP [0(95% CI):-2.36 (-3.47,-1.26) and-1.37 (-2.21,-0.53) mmHg] at late pregnancy> and 4 years post-pregnancy [-1.45 (-2.72,-0.18) and-0.99 (-1.98,-0.01) mmHg]. Higher 0-cryptoxanthin concentrations were associated with lower SBP and DBP [-1.50 (-2.49,-0.51) and-1.20 (-1.95,-0.46) mmHg] at late pregnancy. Individual vitamin E and their pattern were not associated with blood pressure or hypertension.Conclusion: Higher perinatal a-carotene, 0-carotene, and lutein concentrations are associated with lower blood pressure in women at late pregnancy and post-pregnancy. Foods rich in these
C1 [Lai, Jun S.; Yuan, Wen Lun; Chong, Yap Seng; Gluckman, Peter D.; Lee, Yung Seng; Chan, Shiao-Yng; Chong, Mary F. F.] Agcy Sci Technol & Res, Singapore Inst Clin Sci, Singapore, Singapore.
   [Yuan, Wen Lun] Univ Paris, Inserm, INRAE, CRESS, F-75004 Paris, France.
   [Ong, Choon Nam; Chong, Mary F. F.] Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore, Singapore.
   [Ong, Choon Nam; Chong, Yap Seng; Lee, Yung Seng; Chong, Mary F. F.] Natl Univ Hlth Syst, Singapore, Singapore.
   [Tan, Kok Hian] KK Womens & Childrens Hosp, Dept Maternal Fetal Med, Singapore, Singapore.
   [Yap, Fabian] KK Womens & Childrens Hosp, Dept Paediat Endocrinol, Singapore, Singapore.
   [Yap, Fabian; Chan, Jerry K. Y.] Duke NUS Med Sch, Singapore, Singapore.
   [Chong, Yap Seng] Natl Univ Singapore, Yong Loo Lin Sch Med, Singapore, Singapore.
   [Gluckman, Peter D.] Univ Auckland, Liggins Inst, Auckland, New Zealand.
   [Godfrey, Keith M.] Univ Southampton, MRC Lifecourse Epidemiol Unit, Southampton, Hants, England.
   [Godfrey, Keith M.] Univ Southampton, NIHR Southampton Biomed Res Ctr, Southampton, Hants, England.
   [Godfrey, Keith M.] Univ Hosp Southampton NHS Fdn Trust, Southampton, Hants, England.
   [Lee, Yung Seng] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Paediat, Singapore, Singapore.
   [Chan, Jerry K. Y.] KK Womens & Childrens Hosp, Dept Reprod Med, Singapore, Singapore.
   [Chan, Shiao-Yng] Natl Univ Singapore, Natl Univ Hlth Syst, Yong Loo Lin Sch Med, Dept Obstet & Gynaecol, Singapore, Singapore.
C3 Agency for Science Technology & Research (A*STAR); A*STAR - Singapore
   Institute for Clinical Sciences (SICS); Universite Paris Cite; INRAE;
   Institut National de la Sante et de la Recherche Medicale (Inserm);
   National University of Singapore; National University of Singapore; KK
   Women's & Children's Hospital; KK Women's & Children's Hospital;
   National University of Singapore; National University of Singapore;
   University of Auckland; University of Southampton; University of
   Southampton; University of Southampton; University Hospital Southampton
   NHS Foundation Trust; National University of Singapore; KK Women's &
   Children's Hospital; National University of Singapore
RP Lai, JS (corresponding author), Agcy Sci Technol & Res, Singapore Inst Clin Sci, Brenner Ctr Mol Med, 30 Med Dr, Singapore 117609, Singapore.
EM lai_jun_shi@sics.a-star.edu.sg
RI Tan, Kok Hian/AFS-6514-2022; Chan, Shiao/C-8347-2011; Yuan, Wen
   Lun/ABC-4795-2021; Chan, Jerry/ACB-2628-2022; Ong, Choon/E-8638-2010;
   YUAN, Wen Lun/J-1137-2014; Lee, Yung Seng/F-2169-2014
OI Lai, Jun S/0000-0002-9993-8415; Godfrey, Keith/0000-0002-4643-0618;
   YUAN, Wen Lun/0000-0002-7472-5042; Tan, Kok Hian/0000-0003-1945-0266;
   Lee, Yung Seng/0000-0002-1253-0557
FU MRC [MC_UU_12011/4] Funding Source: UKRI
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NR 58
TC 4
Z9 4
U1 0
U2 6
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 0939-4753
EI 1590-3729
J9 NUTR METAB CARDIOVAS
JI Nutr. Metab. Carbiovasc. Dis.
PD DEC
PY 2022
VL 32
IS 12
BP 2811
EP 2821
DI 10.1016/j.numecd.2022.07.019
EA NOV 2022
PG 11
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism; Nutrition
   & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism;
   Nutrition & Dietetics
GA 8I0GL
UT WOS:000921405800015
PM 36184364
OA Green Accepted
DA 2025-06-11
ER

PT J
AU De la Torre, K
   Shin, WK
   Huang, D
   Lee, HW
   Shin, A
   Lee, JK
   Lee, HY
   Kang, D
AF De la Torre, Katherine
   Shin, Woo-Kyoung
   Huang, Dan
   Lee, Hwi-Won
   Shin, Aesun
   Lee, Jong-koo
   Lee, Hae-Young
   Kang, Daehee
TI Mildly elevated diastolic blood pressure increases subsequent risk of
   breast cancer in postmenopausal women in the Health Examinees-Gem study
SO SCIENTIFIC REPORTS
LA English
DT Article
ID METABOLIC SYNDROME; OXIDATIVE STRESS; HYPERTENSION; AGE; MECHANISMS;
   MENOPAUSE; ESTROGEN
AB Epidemiological evidence suggests that hypertension is associated with breast cancer risk. However, previous studies disregard blood pressure components in the healthy population. We aimed to examine the relationship between systolic and diastolic blood pressure and breast cancer risk in a Korean population-based prospective cohort. A total of 73,031 women from the Health Examinees Gem Study were followed from baseline (2004 to 2013) through 2018. Systolic and diastolic blood pressure were measured by trainee physicians at baseline recruitment and then categorized based on the international guidelines for clinical hypertension. Associations between systolic and diastolic blood pressure with overall breast cancer and stratified by premenopausal and postmenopausal status were evaluated using adjusted multivariable Cox proportional hazard regression. A total of 858 breast cancer cases were recorded for a median follow-up period of 9 years. Compared with the normal DBP category (< 85 mmHg), the normal-high category was positively associated with breast cancer risk in postmenopausal women (85-89 mmHg, HR 1.73 95% CI 1.28-2.33), but not in premenopausal women (85-89 mmHg, HR 0.87 95% CI 0.56-1.35). Similar results were found when all cases of self-reported hypertension were excluded. Results for SBP did not show a significant association with breast cancer risk. The association between DBP and breast cancer suggests DBP could be an important factor in cancer prevention, especially for women after menopause. Our study provides a first detailed approach to understanding the importance of diastolic blood pressure for breast cancer prevention and warrants further investigation.
C1 [De la Torre, Katherine; Shin, Woo-Kyoung; Huang, Dan; Lee, Hwi-Won; Shin, Aesun; Kang, Daehee] Seoul Natl Univ, Dept Prevent Med, Coll Med, Seoul 03080, South Korea.
   [De la Torre, Katherine; Lee, Hwi-Won] Seoul Natl Univ, Dept Biomed Sci, Grad Sch, Seoul 03080, South Korea.
   [Shin, Aesun] Seoul Natl Univ, Canc Res Inst, Seoul 03080, South Korea.
   [Lee, Jong-koo] Seoul Natl Univ Hosp, Dept Family Med, Seoul 03080, South Korea.
   [Lee, Hae-Young] Seoul Natl Univ Hosp, Dept Internal Med, Div Cardiol, Seoul 03080, South Korea.
   [Lee, Hae-Young] Seoul Natl Univ, Dept Internal Med, Coll Med, Seoul 03080, South Korea.
   [Shin, Woo-Kyoung; Huang, Dan; Shin, Aesun; Kang, Daehee] Seoul Natl Univ, Integrated Major Innovat Med Sci, Grad Sch, Seoul 03080, South Korea.
C3 Seoul National University (SNU); Seoul National University (SNU); Seoul
   National University (SNU); Seoul National University (SNU); Seoul
   National University Hospital; Seoul National University (SNU); Seoul
   National University Hospital; Seoul National University (SNU); Seoul
   National University (SNU)
RP Kang, D (corresponding author), Seoul Natl Univ, Dept Prevent Med, Coll Med, Seoul 03080, South Korea.; Kang, D (corresponding author), Seoul Natl Univ, Integrated Major Innovat Med Sci, Grad Sch, Seoul 03080, South Korea.
EM dhkang@snu.ac.kr
RI Lee, Youngil/AAX-2787-2021; Lee, Hwi-Won/HLH-1635-2023; De la
   Torre-Cisneros, Katherine/AAT-5100-2020
OI Lee, Jong-koo/0000-0003-4833-1178
FU Korea Centers for Disease Control and Prevention [2004-E71004-00,
   2005-E71011-00, 2005-E71009-00, 2006-E71001-00, 2006-E71004-00,
   2006-E71010-00, 2006E71003-00, 2007-E71004-00, 2007-E71006-00,
   2008-E7100600, 2008-E71008-00, 2009-E71009-00, 2010-E71006-00,
   2011E71006-00, 2012-E71001-00, 2013-E71009-00]
FX This work was supported by the Research Program funded by the Korea
   Centers for Disease Control and Prevention [Grant Number 2004-E71004-00;
   2005-E71011-00; 2005-E71009-00; 2006-E71001-00; 2006-E71004-00;
   2006-E71010-00; 2006E71003-00; 2007-E71004-00; 2007-E71006-00;
   2008-E7100600; 2008-E71008-00; 2009-E71009-00; 2010-E71006-00;
   2011E71006-00; 2012-E71001-00; 2013-E71009-00]. This funding source had
   roles in study design and data collection.
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NR 57
TC 3
Z9 3
U1 0
U2 4
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD SEP 26
PY 2022
VL 12
IS 1
AR 15995
DI 10.1038/s41598-022-19705-4
PG 11
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 4W3VW
UT WOS:000860095400065
PM 36163474
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Yadav, P
   Khurana, A
   Bhatti, JS
   Weiskirchen, R
   Navik, U
AF Yadav, Poonam
   Khurana, Amit
   Bhatti, Jasvinder Singh
   Weiskirchen, Ralf
   Navik, Umashanker
TI Glucagon-like peptide 1 and fibroblast growth factor-21 in non-alcoholic
   steatohepatitis: An experimental to clinical perspective
SO PHARMACOLOGICAL RESEARCH
LA English
DT Article
DE NAFLD; NASH; Inflammation; Fibrosis; GLP-1; FGF-21
ID FATTY LIVER-DISEASE; LONG-ACTING FGF21; REVERSES HEPATIC STEATOSIS;
   GLP-1 RECEPTOR AGONIST; INSULIN SENSITIVITY; OXIDATIVE STRESS;
   BODY-WEIGHT; ANALOG; PATHOGENESIS; LIRAGLUTIDE
AB Non-alcoholic steatohepatitis (NASH) is a progressive form of Non-alcoholic fatty liver disease (NAFLD), which slowly progresses toward cirrhosis and finally leads to the development of hepatocellular carcinoma. Obesity, insulin resistance, type 2 diabetes mellitus and the metabolic syndrome are major risk factors contributing to NAFLD. Targeting these risk factors is a rational option for inhibiting NASH progression. In addition, NASH could be treated with therapies that target the metabolic abnormalities causing disease pathogenesis (such as de novo lipogenesis and insulin resistance) as well with medications targeting downstream processes such as cellular damage, apoptosis, inflammation, and fibrosis. Glucagon-like peptide (GLP-1), is an incretin hormone dysre-gulated in both experimental and clinical NASH, which triggers many signaling pathways including fibroblast growth factor (FGF) that augments NASH pathogenesis. Growing evidence indicates that GLP-1 in concert with FGF-21 plays crucial roles in the conservation of glucose and lipid homeostasis in metabolic disorders. In line, GLP-1 stimulation improves hepatic ballooning, steatosis, and fibrosis in NASH. A recent clinical trial on NASH patients showed that the upregulation of FGF-21 decreases liver fibrosis and hepatic steatosis, thus improving the pathogenesis of NASH. Hence, therapeutic targeting of the GLP-1/FGF axis could be therapeutically beneficial for the remission of NASH. This review outlines the significance of the GLP-1/FGF-21 axis in experimental and clinical NASH and highlights the activity of modulators targeting this axis as potential salutary agents for the treatment of NASH.
C1 [Yadav, Poonam; Navik, Umashanker] Cent Univ Punjab, Dept Pharmacol, Bathinda 151401, Punjab, India.
   [Khurana, Amit; Weiskirchen, Ralf] RWTH Aachen Univ Hosp, Inst Mol Pathobiochem, Expt Gene Therapy & Clin Chem IFMPEGKC, Pauwelsstr 30, D-52074 Aachen, Germany.
   [Bhatti, Jasvinder Singh] Cent Univ Punjab, Dept Human Genet & Mol Med, Bathinda, Punjab, India.
C3 Central University of Punjab; RWTH Aachen University; RWTH Aachen
   University Hospital; Central University of Punjab
RP Navik, U (corresponding author), Cent Univ Punjab, Dept Pharmacol, Bathinda 151401, Punjab, India.; Weiskirchen, R (corresponding author), RWTH Aachen Univ Hosp, Inst Mol Pathobiochem, Expt Gene Therapy & Clin Chem IFMPEGKC, Pauwelsstr 30, D-52074 Aachen, Germany.
EM rweiskirchen@ukaachen.de; uma.shanker@cup.edu.in
RI Bhatti, Jasvinder/AAC-4853-2019; Navik, Umashanker/HDN-1194-2022;
   Khurana, Amit/GLQ-8346-2022; Weiskirchen, Ralf/O-1734-2018
OI Bhatti, Prof. (Dr.) Jasvinder Singh/0000-0001-5480-2584; Weiskirchen,
   Ralf/0000-0003-3888-0931
FU Indian Council of Medical Research (ICMR), Government of India; UGC
FX Authors would like to acknowledge the facility provided by the Central
   University of Punjab, Bathinda (CUPB) . PY thanks the Indian Council of
   Medical Research (ICMR), Government of India for providing a SRF
   fellowship for persuing her PhD work in the Department of Pharmacology
   at the CUPB. UN thanks the UGC for providing the UGC- BSR start-up
   grant.
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NR 117
TC 14
Z9 14
U1 4
U2 33
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 1043-6618
EI 1096-1186
J9 PHARMACOL RES
JI Pharmacol. Res.
PD OCT
PY 2022
VL 184
AR 106426
DI 10.1016/j.phrs.2022.106426
EA SEP 2022
PG 11
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 5A9NX
UT WOS:000863206900004
PM 36075510
DA 2025-06-11
ER

PT J
AU Zhou, YF
   Zhang, HB
   Yao, Y
   Zhang, XY
   Guan, YF
   Zheng, F
AF Zhou, Yunfeng
   Zhang, Haibo
   Yao, Yao
   Zhang, Xiaoyan
   Guan, Youfei
   Zheng, Feng
TI CD4<SUP>+</SUP> T cell activation and inflammation in NASH-related
   fibrosis
SO FRONTIERS IN IMMUNOLOGY
LA English
DT Review
DE Liver fibrosis; NASH; innate immune response; adaptive immunity; CD4(+)
   T cells
ID FATTY LIVER-DISEASE; HEPATIC STELLATE CELLS; ANTIGEN-PRESENTING CELLS;
   TOLL-LIKE RECEPTORS; KUPFFER CELLS; NONALCOHOLIC STEATOHEPATITIS;
   B-CELLS; NATURAL-HISTORY; PPAR-GAMMA; DIET
AB Liver fibrosis is a common pathological feature of end stage liver failure, a severe life-threatening disease worldwide. Nonalcoholic fatty liver disease (NAFLD), especially its more severe form with steatohepatitis (NASH), results from obesity, type 2 diabetes and metabolic syndrome and becomes a leading cause of liver fibrosis. Genetic factor, lipid overload/toxicity, oxidative stress and inflammation have all been implicated in the development and progression of NASH. Both innate immune response and adaptive immunity contribute to NASH-associated inflammation. Innate immunity may cause inflammation and subsequently fibrosis via danger-associated molecular patterns. Increasing evidence indicates that T cell-mediated adaptive immunity also provokes inflammation and fibrosis in NASH via cytotoxicity, cytokines and other proinflammatory and profibrotic mediators. Recently, the single-cell transcriptome profiling has revealed that the populations of CD4(+) T cells, CD8(+) T cells, gamma delta T cells, and TEMs are expanded in the liver with NASH. The activation of T cells requires antigen presentation from professional antigen-presenting cells (APCs), including macrophages, dendritic cells, and B-cells. However, since hepatocytes express MHCII molecules and costimulators, they may also act as an atypical APC to promote T cell activation. Additionally, the phenotypic switch of hepatocytes to proinflammatory cells in NASH contributes to the development of inflammation. In this review, we focus on T cells and in particular CD4(+) T cells and discuss the role of different subsets of CD4(+) T cells including Th1, Th2, Th17, Th22, and Treg in NASH-related liver inflammation and fibrosis.
C1 [Zhou, Yunfeng] Shenzhen Univ, Med Res Ctr, Dept Physiol, Shenzhen, Peoples R China.
   [Zhang, Haibo; Guan, Youfei; Zheng, Feng] Dalian Med Univ, Adv Inst Med Sci, Dalian, Peoples R China.
   [Yao, Yao] Nantong Univ, Affiliated Hosp, Div Nephrol, Nantong, Peoples R China.
   [Zhang, Xiaoyan] East China Normal Univ, Wuhu Hosp, Shanghai, Peoples R China.
   [Zhang, Xiaoyan] East China Normal Univ, Hlth Sci Ctr, Shanghai, Peoples R China.
C3 Shenzhen University; Dalian Medical University; Nantong University; East
   China Normal University; East China Normal University
RP Guan, YF; Zheng, F (corresponding author), Dalian Med Univ, Adv Inst Med Sci, Dalian, Peoples R China.
RI Zhang, Haibo/HLP-9266-2023; ZHOU, yf/IAO-5497-2023; Zhang,
   Xiaoling/D-4589-2015
OI Zhang, Haibo/0000-0003-1755-1813; ZHANG, XIAOYAN/0000-0002-4060-2423
FU National Natural Science Foundation of China; Shenzhen Basic Research
   Project;  [81970606];  [81970595];  [81970636];  [81970642]; 
   [JCYJ20210324095005015]
FX Funding This work was supported by the National Natural Science
   Foundation of China (No. 81970606, 81970595, 81970636 & 81970642); the
   Shenzhen Basic Research Project (No. JCYJ20210324095005015).
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NR 111
TC 58
Z9 63
U1 2
U2 25
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-3224
J9 FRONT IMMUNOL
JI Front. Immunol.
PD AUG 10
PY 2022
VL 13
AR 967410
DI 10.3389/fimmu.2022.967410
PG 10
WC Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology
GA 3Y9BX
UT WOS:000844018300001
PM 36032141
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Di Martino, DD
   Avagliano, L
   Ferrazzi, E
   Fusè, F
   Sterpi, V
   Parasiliti, M
   Stampalija, T
   Zullino, S
   Farina, A
   Bulfamante, GP
   Di Maso, M
   D'Ambrosi, F
AF Di Martino, Daniela Denis
   Avagliano, Laura
   Ferrazzi, Enrico
   Fuse, Federica
   Sterpi, Vittoria
   Parasiliti, Marco
   Stampalija, Tamara
   Zullino, Sara
   Farina, Antonio
   Bulfamante, Gaetano Pietro
   Di Maso, Matteo
   D'Ambrosi, Francesco
TI Hypertensive Disorders of Pregnancy and Fetal Growth Restriction:
   Clinical Characteristics and Placental Lesions and Possible Preventive
   Nutritional Targets
SO NUTRIENTS
LA English
DT Article
DE fetal vascular malperfusion; feto-placental Doppler; maternal vascular
   malperfusion; Mediterranean diet; placenta pathology; preeclampsia;
   sFlt-1; PlGF ratio
ID OXIDATIVE STRESS; INTRAUTERINE GROWTH; DIETARY PATTERNS; BLOOD-FLOW;
   MEDITERRANEAN DIET; EARLY-ONSET; PREECLAMPSIA; BIOMARKERS; TERM;
   CONSEQUENCES
AB Background: The purpose of this study was to describe the placental lesions in pregnancies complicated by hypertensive disorders (HDP) and/or fetal growth restriction (FGR) and in uneventful control pregnancies. Methods: This is a case control study that included singleton pregnancies with HDP and normally grown fetus (HDP-AGA fetus), with HDP and FGR, early FGR, late FGR, and uneventful pregnancies. Feto-placental Doppler velocimetry and sFlt-1/PlGF ratio were performed. Placental histology was evaluated blinded according to the Amsterdam Consensus criteria. Results: Placental lesions with maternal vascular malperfusion (MVM) were significantly more frequent in HDP-FGR and early FGR (92% and 83%). MVM were significantly associated with abnormal feto-placental Doppler parameters, especially in early FGR. Delayed villous maturation (DVM) was associated with late FGR (83%). HDP-AGA fetus cases presented a heterogeneous pattern of placental lesions, including 60% of cases with MVM, but were not associated with abnormal Doppler feto-placental velocimetry. Conclusions: We found a prevalence of placental maternal vascular malperfusion in HDP-FGR and early FGR groups. These lesions were also associated with abnormal, anti-, and angiogenic markers. Conversely HDP-AGA fetus and late FGR presented more heterogeneous placental lesions not severe enough to cause feto-placental Doppler anomalies. These conditions are likely associated with different etiologies, such as maternal pre-pregnancy risk factors for metabolic syndrome. These findings suggest a possible preventive nutritional approach in addition to low-dose aspirin in pregnant women with predisposing factors for HDP-AGA fetuses and late FGR.
C1 [Di Martino, Daniela Denis; Ferrazzi, Enrico; Sterpi, Vittoria; Parasiliti, Marco; D'Ambrosi, Francesco] Fdn IRCCS Ca Granda Osped Maggiore Policlin, Dept Woman Child & Neonate, I-20122 Milan, Italy.
   [Avagliano, Laura; Bulfamante, Gaetano Pietro] San Paolo Hosp, Dept Hlth Sci, ASST St Paolo & Carlo, I-20142 Milan, Italy.
   [Ferrazzi, Enrico] Univ Milan, Dept Clin & Community Hlth Sci, I-20122 Milan, Italy.
   [Fuse, Federica] Buzzi Childrens Hosp, Dept Woman Mother & Neonate, I-20154 Milan, Italy.
   [Stampalija, Tamara] IRCCS Burlo Garofolo, Inst Maternal & Child Hlth, Unit Fetal Med & Prenatal Diag, I-34137 Trieste, Italy.
   [Stampalija, Tamara] Univ Trieste, Dept Med Surg & Hlth Sci, I-34127 Trieste, Italy.
   [Zullino, Sara] Pisan Univ Hosp, Dept Obstet & Gynaecol, I-56124 Pisa, Italy.
   [Farina, Antonio] Univ Bologna, St Orsola Malpighi Hosp, Div Obstet & Prenatal Med, Dept Med & Surg DIMEC, I-40126 Bologna, Italy.
   [Bulfamante, Gaetano Pietro] San Paolo Hosp, ASST Santi Paolo & Carlo, Unit Human Pathol, I-20142 Milan, Italy.
   [Di Maso, Matteo] Univ Milan, Branch Med Stat Biometry & Epidemiol G A Maccacar, Dept Clin Sci & Community Hlth, I-20122 Milan, Italy.
C3 IRCCS Ca Granda Ospedale Maggiore Policlinico; San Paolo-Polo
   Universitaria Hospital; University of Milan; IRCCS Burlo Garofolo;
   University of Trieste; University of Bologna; IRCCS Azienda
   Ospedaliero-Universitaria di Bologna; San Paolo-Polo Universitaria
   Hospital; University of Milan
RP Ferrazzi, E (corresponding author), Fdn IRCCS Ca Granda Osped Maggiore Policlin, Dept Woman Child & Neonate, I-20122 Milan, Italy.; Ferrazzi, E (corresponding author), Univ Milan, Dept Clin & Community Hlth Sci, I-20122 Milan, Italy.
EM enrico.ferrazzi@unimi.it
RI Parasiliti, Marco/KBB-9763-2024; Stampalija, Tamara/K-4900-2014;
   ZULLINO, SARA/AAC-2159-2019; Avagliano, Laura/AAM-3412-2021; di martino,
   daniela/AAB-8907-2019; D'Ambrosi, Francesco/AAA-9136-2020; Di Maso,
   Matteo/AAC-4816-2022
OI AVAGLIANO, LAURA/0000-0002-7808-7578; D'Ambrosi,
   Francesco/0000-0002-5130-2266; Sterpi, Vittoria/0000-0002-4629-3406; Di
   Martino, Daniela Denis/0000-0003-0229-384X; Zullino,
   sara/0000-0002-0289-5659; /0000-0001-5243-0537; Farina,
   Antonio/0000-0002-6862-1810
FU A.S.M., Charity
FX This study was supported by a grant from A.S.M., Charity, and partially
   supported by the CURE-Charity for research in prenatal medicine.
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NR 58
TC 15
Z9 15
U1 1
U2 4
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD AUG
PY 2022
VL 14
IS 16
AR 3276
DI 10.3390/nu14163276
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 4B5LE
UT WOS:000845817900001
PM 36014782
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Witte, K
   Sabat, R
   Witte-Händel, E
   Ghoreschi, K
   Wolk, K
AF Witte, Katrin
   Sabat, Robert
   Witte-Haendel, Ellen
   Ghoreschi, Kamran
   Wolk, Kerstin
TI Phytotherapeuthics Affecting the IL-1/IL-17/G-CSF Axis: A Complementary
   Treatment Option for Hidradenitis Suppurativa?
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE acne inversa; IL-1; IL-17; G-CSF; TNF-alpha; LCN2; neutrophilic
   granulocytes; polyphenol
ID NF-KAPPA-B; ASHWAGANDHA ROOT EXTRACT; WITHANIA-SOMNIFERA; DOUBLE-BLIND;
   NLRP3 INFLAMMASOME; CENTELLA-ASIATICA; T-CELLS;
   EPIGALLOCATECHIN-3-GALLATE; WITHAFERIN; STRESS
AB Hidradenitis suppurativa (HS; also designated as acne inversa) is a chronic inflammatory disease characterized by painful skin lesions that occur in the axillary, inguinal, gluteal and perianal areas of the body. These lesions contain recurring deep-seated, inflamed nodules and pus-discharging abscesses and fistulas. Affecting about 1% of the population, this common disease has gained appropriate clinical attention in the last years. Associated with numerous comorbidities including metabolic syndrome, HS is considered a systemic disease that severely impairs the quality of life and shortens life expectancy. Therapeutic options for HS are limited, comprising long-term antibiotic treatment, the surgical removal of affected skin areas, and neutralization of TNF-alpha, the only approved systemic treatment. Novel treatment options are needed to close the therapeutic gap. HS pathogenesis is increasingly better understood. In fact, neutrophilic granulocytes (neutrophils) seem to be decisive for the development of the purulent destructive skin inflammation in HS. Recent findings suggest a key role of the immune mediators IL-1 beta, IL-17A and G-CSF in the migration into and activation of neutrophils in the skin. Although phytomedical drugs display potent immunoregulatory properties and have been suggested as complementary therapy in several chronic disorders, their application in HS has not been considered so far. In this review, we describe the IL-1/IL-17/G-CSF axis and evaluate it as potential target for an integrated phytomedical treatment of HS.
C1 [Witte, Katrin; Sabat, Robert; Witte-Haendel, Ellen; Wolk, Kerstin] Charite Univ Med Berlin, Psoriasis Res & Treatment Ctr, D-10117 Berlin, Germany.
   [Witte, Katrin; Sabat, Robert; Witte-Haendel, Ellen; Wolk, Kerstin] Charite Univ Med Berlin, Interdisciplinary Grp Mol Immunopathol, Dermatol Med Immunol, D-10117 Berlin, Germany.
   [Witte, Katrin; Wolk, Kerstin] Charite Univ Med Berlin, Inflammat & Regenerat Skin, BIH Ctr Regenerat Therapies, D-13353 Berlin, Germany.
   [Ghoreschi, Kamran] Charite Univ Med Berlin, Dept Dermatol Venereol & Allergol, D-10117 Berlin, Germany.
C3 Berlin Institute of Health; Free University of Berlin; Humboldt
   University of Berlin; Charite Universitatsmedizin Berlin; Berlin
   Institute of Health; Free University of Berlin; Humboldt University of
   Berlin; Charite Universitatsmedizin Berlin; Berlin Institute of Health;
   Free University of Berlin; Humboldt University of Berlin; Charite
   Universitatsmedizin Berlin; Berlin Institute of Health; Free University
   of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin
   Berlin
RP Witte, K; Sabat, R (corresponding author), Charite Univ Med Berlin, Psoriasis Res & Treatment Ctr, D-10117 Berlin, Germany.; Witte, K; Sabat, R (corresponding author), Charite Univ Med Berlin, Interdisciplinary Grp Mol Immunopathol, Dermatol Med Immunol, D-10117 Berlin, Germany.; Witte, K (corresponding author), Charite Univ Med Berlin, Inflammat & Regenerat Skin, BIH Ctr Regenerat Therapies, D-13353 Berlin, Germany.
EM katrin.witte@charite.de; robert.sabat@charite.de
RI Wolk, Kerstin/O-1205-2013
OI Ghoreschi, Kamran/0000-0002-5526-7517; Wolk,
   Kerstin/0000-0002-7689-4130; Sabat, Robert/0000-0002-0198-940X
FU Open Access Publication Fund of Charite-Universitatsmedizin Berlin;
   German Research Foundation (DFG)
FX We acknowledge the financial support from the Open Access Publication
   Fund of Charite-Universitatsmedizin Berlin and the German Research
   Foundation (DFG). We thank Yakov Oskanov, Lubomir Jilek and Thalabhula
   for botanical pictures that were obtained via 123RF.com (accessed on 8
   August 2022).
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NR 120
TC 5
Z9 5
U1 0
U2 3
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD AUG
PY 2022
VL 23
IS 16
AR 9057
DI 10.3390/ijms23169057
PG 16
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 4B1QN
UT WOS:000845561400001
PM 36012322
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Li, M
   Zheng, QD
   Miller, JD
   Zuo, PP
   Yuan, XD
   Feng, JT
   Liu, C
   Bao, S
   Lou, QQ
AF Li, Min
   Zheng, Qidong
   Miller, Joshua D.
   Zuo, Panpan
   Yuan, Xiaodan
   Feng, Jitao
   Liu, Chao
   Bao, Shan
   Lou, Qingqing
TI Aerobic training reduces pancreatic fat content and improves β-cell
   function: A randomized controlled trial using IDEAL-IQ magnetic
   resonance imaging
SO DIABETES-METABOLISM RESEARCH AND REVIEWS
LA English
DT Article
DE beta-cell function; aerobic training; pancreatic fat content; type 2
   diabetes mellitus
ID ADIPOSE-TISSUE; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   DIABETES-MELLITUS; ECTOPIC FAT; TYPE-2; EXERCISE; ASSOCIATION; STRESS;
   ACTIVATION
AB Aims: To explore the effects of six months of moderate-intensity aerobic exercise on pancreatic fat content and its impact on beta-cell function.
   Materials and Methods: A total of 106 patients with type 2 diabetes mellitus were randomized to either a moderate-intensity aerobic training group (three times a week, including 5 min warm-up, 50 min aerobic dancing, and 5 min relaxation, n = 53) or control group (n = 53) with 6-month intervention. The primary endpoint was change in pancreatic fat content. An intention-to-treat analysis was conducted.
   Results: Eighty-six patients completed the study with 43 patients in the aerobic training group. The average age, HbA1c, and pancreatic fat content for all participants (106 patients) were 66.39 +/- 5.59 years, 7.05 +/- 1.24%, and 10.35 +/- 9.20%, respectively. Nearly half (49.06%) of patients were males. Subjects in the aerobic training group saw a significant reduction in pancreatic fat content when compared to controls (p = 0.001). In logistic regression models containing age, diabetes duration, change in BMI, smoking/drinking status, changes in lipid indices, and other abdominal fat content, only reduction in pancreatic fat content (p < 0.05) was an independent protective factor for 13-cell function and HbA1c.
   Conclusions: Six months of moderate-intensity aerobic training significantly reduced the pancreatic fat content. The reduction of pancreatic fat content was an independent protective factor for beta-cell function and HbA1c.
C1 [Li, Min; Lou, Qingqing] Hainan Med Univ, Dept Endocrinol, Affiliated Hosp 1, Haikou 570102, Hainan, Peoples R China.
   [Li, Min] Nanjing Univ Chinese Med, Nursing Coll, Nanjing, Peoples R China.
   [Zheng, Qidong] Yuhuan Second Peoples Hosp, Dept Internal Med, Yuhuan, Peoples R China.
   [Miller, Joshua D.] SUNY Stony Brook, Dept Med, Div Endocrinol & Metab, Renaissance Sch Med, Stony Brook, NY 11794 USA.
   [Zuo, Panpan] Taizhou Polytehn Coll, Sch Nursing, Taizhou, Peoples R China.
   [Yuan, Xiaodan] Nanjing Univ Chinese Med, Affiliated Hosp Integrated Tradit Chinese & Weste, Dept Hlth Educ, Nanjing, Peoples R China.
   [Feng, Jitao] Nanjing Pukou Hosp Tradit Chinese Med, Dept Radiol, Nanjing, Peoples R China.
   [Liu, Chao] Nanjing Univ Chinese Med, Affiliated Hosp Integrated Tradit Chinese & Weste, Res Ctr Endocrine & Metab Dis, Nanjing, Peoples R China.
   [Bao, Shan] Hainan Gen Hosp, Dept Gynaecol & Obstet, 19 Xiuhua Rd, Haikou 570311, Hainan, Peoples R China.
C3 Hainan Medical University; Nanjing University of Chinese Medicine; State
   University of New York (SUNY) System; Stony Brook University; Stony
   Brook University Hospital; Nanjing University of Chinese Medicine;
   Nanjing University of Chinese Medicine; Hainan Medical University
RP Lou, QQ (corresponding author), Hainan Med Univ, Dept Endocrinol, Affiliated Hosp 1, Haikou 570102, Hainan, Peoples R China.; Bao, S (corresponding author), Hainan Gen Hosp, Dept Gynaecol & Obstet, 19 Xiuhua Rd, Haikou 570311, Hainan, Peoples R China.
EM baoshan3@126.com; 2444890144@qq.com
RI Zuo, Panpan/AAB-1794-2019
FU National Natural Scientific Foundation of China; Six Talent Peaks
   Project in Jiangsu Province; Hainan Province Clinical Medical Center
FX National Natural Scientific Foundation of China; Six Talent Peaks
   Project in Jiangsu Province; Hainan Province Clinical Medical Center
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NR 50
TC 5
Z9 6
U1 3
U2 17
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1520-7552
EI 1520-7560
J9 DIABETES-METAB RES
JI Diabetes-Metab. Res. Rev.
PD MAY
PY 2022
VL 38
IS 4
AR e3516
DI 10.1002/dmrr.3516
EA FEB 2022
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 0X3KV
UT WOS:000749532600001
PM 34963031
DA 2025-06-11
ER

PT J
AU Demirci, S
   Gün, C
AF Demirci, Sule
   Gun, Cennet
TI Zinc Supplementation Improved Neuropeptide Y, Nesfatin-1, Leptin,
   C-reactive protein, and HOMA-IR of Diet-Induced Obese Rats
SO BIOLOGICAL TRACE ELEMENT RESEARCH
LA English
DT Article
DE Zinc (Zn); Nesfatin-1; Neuropeptide Y (NPY); Obesity; HOMA-IR;
   C-reactive protein
ID HIGH-FAT DIET; INSULIN-RESISTANCE; METABOLIC SYNDROME; OXIDATIVE STRESS;
   ADIPOSE-TISSUE; TNF-ALPHA; GLUCOSE; INFLAMMATION; ADIPOKINE; NEURONS
AB Obesity is a mild chronic inflammation that causes many metabolic diseases. It was aimed to investigate some parameters affective on the energy metabolism by adding zinc (Zn, ZnSO4) to drinking water of diet-induced obese rats. Five-week aged, male Sprague Dawley rats divided into as control group, consuming standard rat diet, and high-fat diet (HFD) group. After obesity induced by feeding HFD for 8 weeks, the obese rats were divided into Zn-supplemented obese group (HFD + obese + Zn; 150 mg Zn/L (for 6 weeks), 235 mg Zn/L (7th week), 250 mg Zn/L (8th week) in drinking water) and obese group (HFD + obese). Mean body weight, serum concentrations of C-reactive protein, neuropeptide-Y, leptin, insulin fasting blood glucose, and HOMA-IR were statistically decreased by given Zn in HFD + obese + Zn group compared to HFD + obese rats. It was observed that the total cholesterol, LDL, and HDL cholesterol levels of HFD + obese + Zn group became closer to the control group level, and Zn supplementation caused a statistically significant decrease in cholesterol profile than HFD + obese rats. Also, increased mean serum nesfatin-1 level, an effective protein for the formation of satiety, was analyzed in HFD + obese + Zn group when compared to HFD + obese ones. Serum triglyceride concentration tended to decrease with the effect of Zn in obese rats. In conclusion, it can be said that oral use of Zn could improve energy balance and prevent the occurrence of metabolic diseases related to obesity depending on the anti-inflammatory effect of Zn.
C1 [Demirci, Sule] Burdur Mehmet Akif Ersoy Univ, Fac Vet Med, Physiol Dept, Burdur, Turkey.
   [Gun, Cennet] Yalvac State Hosp, Isparta, Turkey.
C3 Mehmet Akif Ersoy University; Isparta Yalvac State Hospital
RP Demirci, S (corresponding author), Burdur Mehmet Akif Ersoy Univ, Fac Vet Med, Physiol Dept, Burdur, Turkey.
EM suledemirci67@hotmail.com; cennetgun989@gmail.com
FU Burdur Mehmet Akif Ersoy University Scientific Research Projects
   Commission [0418-YL-17]
FX This work was financially supported by Burdur Mehmet Akif Ersoy
   University Scientific Research Projects Commission by giving project
   number 0418-YL-17. Suleyman Gun and Hatice Gun also financially
   supported the project.
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NR 81
TC 3
Z9 4
U1 0
U2 8
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0163-4984
EI 1559-0720
J9 BIOL TRACE ELEM RES
JI Biol. Trace Elem. Res.
PD SEP
PY 2022
VL 200
IS 9
BP 3996
EP 4006
DI 10.1007/s12011-021-02987-6
EA OCT 2021
PG 11
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 3T2IX
UT WOS:000712524900001
PM 34708332
DA 2025-06-11
ER

PT J
AU Guzmán, TJ
   Martínez-Ayala, AL
   García-López, PM
   Soto-Luna, IC
   Gurrola-Díaz, CM
AF Guzman, Tereso J.
   Martinez-Ayala, Alma L.
   Garcia-Lopez, Pedro M.
   Soto-Luna, Irma C.
   Gurrola-Diaz, Carmen M.
TI Effect of the acute and chronic administration of Lupinus albus
   β-conglutin on glycaemia, circulating cholesterol, and genes potentially
   involved
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Article
DE Legumes; Nutraceuticals; Postprandial hyperglycemia; Glucose metabolism;
   Anticholesteremic agents; Gene expression profiling
ID INSULIN SENSITIVITY; METABOLIC SYNDROME; BODY-WEIGHT; PROTEIN; GLUCOSE;
   SEED; EXPRESSION; ROSIGLITAZONE; CONSUMPTION; RATS
AB Constituents of lupin seeds, like gamma-conglutin and lupanine, have gained attention as potential complementary treatments for dysglycaemia management. Notwithstanding, the effect of other lupin components on carbohydrate metabolism, including beta-conglutin protein, has received little attention. Here, we investigated the influence of the acute and chronic administration of beta-conglutin on glycaemia modulation in normal and streptozotocin induced-to-diabetes rats. We analysed the liver transcriptome modulation exerted by beta-conglutin in diabetes induced rats using DNA microarrays to scout for potential molecular targets and pathways involved in this biological response. The acute administration of beta-conglutin reduced the incremental area under the curve of glycaemia in normal and diabetes-induced animals. In a seven-day study with diabetic animals, glycaemia increased significantly in non-treated animals but remained unchanged in animals treated with a daily dose of beta-conglutin. Total cholesterol was significantly lower at the end of the experimental period (-21.8 %, p = 0.039). The microarray and gene ontology analyses revealed several targets and pathways potentially modulated by beta-conglutin treatment, including a possible down-regulation of Jun kinase activity. Moreover, our data indicate that targets related to oxidative stress, inflammation, and estrogenic activity might orchestrate these metabolic effects. In conclusion, our findings show that beta-conglutin may help manage postprandial glycaemia and reduce cholesterol levels under the dysglycaemia stage. We identified and proposed new potential molecular targets for further research related to the mechanism of action of beta-conglutin.
C1 [Guzman, Tereso J.; Soto-Luna, Irma C.; Gurrola-Diaz, Carmen M.] Univ Guadalajara, Inst Invest Enfermedades Cron Degenerat, Inst Transdisciplinar Invest & Innovac Salud, Dept Biol Mol & Genom,Ctr Univ Ciencias Salud, Guadalajara, Jalisco, Mexico.
   [Martinez-Ayala, Alma L.] Inst Politecn Nacl, Ctr Desarrollo Prod Biot, Yautepec, Morelos, Mexico.
   [Garcia-Lopez, Pedro M.] Univ Guadalajara, Lab Prod Biot, Dept Bot & Zool, Ctr Univ Ciencias Biol & Agr, Zapopan, Jalisco, Mexico.
C3 Universidad de Guadalajara; Instituto Politecnico Nacional - Mexico;
   Universidad de Guadalajara
RP Gurrola-Díaz, CM (corresponding author), Sierra Mojada 950, Guadalajara 44340, Jalisco, Mexico.
EM goozman57@hotmail.com; almarayala@hotmail.com; macedonio54@gmail.com;
   cathy.sotoluna@yahoo.com.mx; carmenhpv@yahoo.de
RI Guzmán, Tereso/AAA-4056-2021; Martínez-Ayala, Alma/O-4061-2019
OI Guzman, Tereso/0000-0002-1900-5931; Gurrola-Diaz, Carmen
   Magdalena/0000-0002-9851-8961
FU Consejo Nacional de Ciencia y Tecnologia (CONACyT) [60283]; Universidad
   de Guadalajara [REC/198/2017, REC/164/2017, REG/0964/19]; CONACyT
   [598227]
FX The study was funded by Consejo Nacional de Ciencia y Tecnologia
   (CONACyT) through a research grant assigned to C.M.G.-D. (number:
   60283). The Universidad de Guadalajara provided partial financial
   support through grants REC/198/2017, REC/164/2017, and REG/0964/19.
   T.J.G. was the recipient of a graduate scholarship by CONACyT (number:
   598227).
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NR 60
TC 6
Z9 6
U1 0
U2 3
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD JAN
PY 2021
VL 133
AR 110969
DI 10.1016/j.biopha.2020.110969
PG 12
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA PN6UP
UT WOS:000604612200007
PM 33166762
DA 2025-06-11
ER

PT J
AU Chang, YS
   Ho, CH
   Chu, CC
   Wang, JJ
   Tseng, SH
   Jan, RL
AF Chang, Yuh-Shin
   Ho, Chung-Han
   Chu, Chin-Chen
   Wang, Jhi-Joung
   Tseng, Sung-Huei
   Jan, Ren-Long
TI Risk of retinal artery occlusion in patients with diabetes mellitus: A
   retrospective large-scale cohort study
SO PLOS ONE
LA English
DT Article
ID INSULIN-RESISTANCE; ENDOTHELIAL DYSFUNCTION; CARDIOVASCULAR-DISEASE;
   METABOLIC SYNDROME; OXIDATIVE STRESS; VESSEL CALIBER; RETINOPATHY;
   ATHEROSCLEROSIS; COMPLICATIONS; HYPERTENSION
AB There is a globally increasing prevalence and incidence of diabetes mellitus (DM). Prolonged hyperglycaemia could lead to both macrovascular damage, such as carotid artery atherosclerosis, and microvascular damage, such as retinal arteriolar narrowing, and might contribute to retinal artery occlusion (RAO). Accordingly, it is important to determine whether DM is a contrubuting factor of RAO. We conducted a retrospective cohort study that included 241,196 DM patients from the Longitudinal Cohort of Diabetes Patients Database who were recruited between 2003 and 2005. An age- and sex-matched non-DM control group included the same number of patients who were selected from the Taiwan Longitudinal Health Insurance Database of 2000. Relevant data of each patient were collected from the index date until December 2013. The incidence and risk of RAO were calculated and compared between the DM and non-DM groups. The hazard ratio for RAO was calculated using Cox proportional hazards regression analysis after adjusting for confounders. The cumulative incidence rate of RAO was calculated by Kaplan Meier analysis. In total, 317 patients with DM and 144 controls developed RAO during the follow-up period, leading to an incidence rate of RAO in DM patients that was 2.30 times (95% confidence interval [CI] = 1.89-2.80) greater than that in controls. After adjustment for potential confounders, patients with DM were 2.11 times (95% CI, 1.71-2.59) more likely to develop RAO in the total study cohort. In conclusion, DM increases the risk of RAO, which is an interdisciplinary emergency. Close collaboration between endocrinologists and ophthalmologists is important in managing RAO following DM.
C1 [Chang, Yuh-Shin; Tseng, Sung-Huei] Chi Mei Med Ctr, Dept Ophthalmol, Tainan, Taiwan.
   [Chang, Yuh-Shin; Jan, Ren-Long] Chang Jung Christian Univ, Grad Inst Med Sci, Coll Hlth Sci, Tainan, Taiwan.
   [Ho, Chung-Han; Wang, Jhi-Joung] Chi Mei Med Ctr, Dept Med Res, Tainan, Taiwan.
   [Ho, Chung-Han] Chia Nan Univ Pharm & Sci, Dept Hosp & Hlth Care Adm, Tainan, Taiwan.
   [Chu, Chin-Chen; Wang, Jhi-Joung] Chi Mei Med Ctr, Dept Anesthesiol, Tainan, Taiwan.
   [Chu, Chin-Chen] Chia Nan Univ Pharm & Sci, Dept Recreat & Hlth Care Management, Tainan, Taiwan.
   [Tseng, Sung-Huei] Natl Cheng Kung Univ, Natl Cheng Kung Univ Hosp, Dept Ophthalmol, Coll Med, Tainan, Taiwan.
   [Jan, Ren-Long] Chi Mei Med Ctr, Dept Pediat, Tainan, Taiwan.
C3 Chi Mei Hospital; Chang Jung Christian University; Chi Mei Hospital;
   Chia Nan University of Pharmacy & Science; Chi Mei Hospital; Chia Nan
   University of Pharmacy & Science; National Cheng Kung University;
   National Cheng Kung University Hospital; Chi Mei Hospital
RP Jan, RL (corresponding author), Chang Jung Christian Univ, Grad Inst Med Sci, Coll Hlth Sci, Tainan, Taiwan.; Jan, RL (corresponding author), Chi Mei Med Ctr, Dept Pediat, Tainan, Taiwan.
EM renlongjan@gmail.com
RI Chu, Chin-Chen/HPG-9246-2023
OI Jan, Ren-Long/0000-0002-3205-7621; Ho, Chung-Han/0000-0001-5925-8477
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NR 50
TC 23
Z9 23
U1 0
U2 4
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD AUG 9
PY 2018
VL 13
IS 8
AR e0201627
DI 10.1371/journal.pone.0201627
PG 13
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA GP9JF
UT WOS:000441232600040
PM 30091989
OA Green Submitted, gold, Green Published
DA 2025-06-11
ER

PT J
AU Imai, Y
   Fink, BD
   Promes, JA
   Kulkarni, CA
   Kerns, RJ
   Sivitz, WI
AF Imai, Yumi
   Fink, Brian D.
   Promes, Joseph A.
   Kulkarni, Chaitanya A.
   Kerns, Robert J.
   Sivitz, William I.
TI Effect of a mitochondrial-targeted coenzyme Q analog on pancreatic -cell
   function and energetics in high fat fed obese mice
SO PHARMACOLOGY RESEARCH & PERSPECTIVES
LA English
DT Article
DE antioxidants; beta-cells; coenzyme Q; insulin; mitochondria; obesity
ID INSULIN-RESISTANCE; METABOLIC SYNDROME; ANTIOXIDANT; SENESCENCE; ISLETS;
   MODEL
AB We recently reported that mitoquinone (mitoQ, 500mol/L) added to drinking water of C57BL/6J mice attenuated weight gain and reduced oxidative stress when administered to high-fat (HF) fed mice. Here, we examined the effects of mitoQ administered to HF fed mice on pancreatic islet morphology, dynamics of insulin secretion, and islet mitochondrial metabolism. C57BL/6J mice were fed HF for 130days while we administered vehicle (cyclodextrin [CD]) or mitoQ added to the drinking water at up to 500mol/L. MitoQ-treated mice vs vehicle gained significantly less weight, expended significantly more energy as determined by indirect calorimetry, and trended to consume less (nonsignificant) food. As we and others reported before, mitoQ-treated mice drank less water but showed no difference in percent body fluid by nuclear magnetic resonance. Circulating insulin and glucose-stimulated insulin secretion by isolated islets were decreased in mitoQ-treated mice while insulin sensitivity (plasma insulin x glucose) was greater. Islet respiration as basal oxygen consumption (OCR), OCR directed at ATP synthesis, and maximal uncoupled OCR were also reduced in mitoQ-treated mice. Quantitative morphologic studies revealed that islet size was reduced in the mitoQ-treated mice while visual inspection of histochemically stained sections suggested that mitoQ reduced islet lipid peroxides. MitoQ markedly improved liver function as determined by plasma alanine aminotransferase. In summary, mitoQ treatment reduced the demand for insulin and reduced islet size, likely consequent to the action of mitoQ to mitigate weight gain and improve liver function.
C1 [Imai, Yumi; Fink, Brian D.; Promes, Joseph A.; Sivitz, William I.] Univ Iowa, Dept Internal Med, Div Endocrinol & Metab, Iowa City, IA 52242 USA.
   [Imai, Yumi; Fink, Brian D.; Promes, Joseph A.; Sivitz, William I.] Iowa City Vet Affairs Med Ctr, Iowa City, IA USA.
   [Kulkarni, Chaitanya A.; Kerns, Robert J.] Univ Iowa, Dept Pharmaceut Sci & Expt Therapeut, Iowa City, IA USA.
C3 University of Iowa; US Department of Veterans Affairs; Veterans Health
   Administration (VHA); Iowa City VA Health Care System; University of
   Iowa
RP Sivitz, WI (corresponding author), Univ Iowa, Dept Internal Med, Div Endocrinol & Metab, Primary Lab, Iowa City, IA 52242 USA.
EM william-sivitz@uiowa.edu
RI Imai, Yumi/IWE-1907-2023; Kulkarni, Chaitanya/K-5349-2019
OI Fink, Brian/0000-0002-1149-7935; Sivitz, William/0000-0002-7829-0189;
   Imai, Yumi/0000-0001-5046-4223; Kulkarni, Chaitanya/0000-0002-6836-0518
FU Department of Veterans Affairs [5I01BX000285-06]; American Heart
   Association [14EIA18860041]; National Institute of Health [5R01HL073166,
   HL084207]; National Institutes of Health [DK090490]; Iowa Center for
   Biocatalysis and Bioprocessing [T32 GM008365]; Fraternal Order of the
   Eagles; NIH Predoctoral Training Program in Biotechnology [T32
   GM008365]; National Heart Lung and Blood Institute [P01HL084207] Funding
   Source: NIH RePORTER
FX Department of Veterans Affairs, Grant/Award Number: 5I01BX000285-06;
   American Heart Association, Grant/Award Number: 14EIA18860041; National
   Institute of Health, Grant/Award Number: 5R01HL073166, HL084207;
   National Institutes of Health, Grant/Award Number: DK090490; Iowa Center
   for Biocatalysis and Bioprocessing, associated with NIH Predoctoral
   Training Program in Biotechnology, Grant/Award Number: T32 GM008365;
   Fraternal Order of the Eagles
CR Almind K, 2007, P NATL ACAD SCI USA, V104, P2366, DOI 10.1073/pnas.0610416104
   Amer Diabet Assoc, 2018, DIABETES CARE, V41, pS38, DOI 10.2337/dc18-S004
   Apovian CM, 2016, NEW ENGL J MED, V374, P177, DOI 10.1056/NEJMe1514957
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NR 27
TC 23
Z9 26
U1 0
U2 5
PU JOHN WILEY & SONS LTD
PI CHICHESTER
PA THE ATRIUM, SOUTHERN GATE, CHICHESTER PO19 8SQ, W SUSSEX, ENGLAND
SN 2052-1707
J9 PHARMACOL RES PERSPE
JI Pharmacol. Res. Perspect.
PD JUN
PY 2018
VL 6
IS 3
AR e00393
DI 10.1002/prp2.393
PG 11
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA GI2WG
UT WOS:000434232000001
PM 29864244
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Xie, LH
   Su, HM
   Sun, CD
   Zheng, XD
   Chen, W
AF Xie, Lianghua
   Su, Hongming
   Sun, Chongde
   Zheng, Xiaodong
   Chen, Wei
TI Recent advances in understanding the anti-obesity activity of
   anthocyanins and their biosynthesis in microorganisms
SO TRENDS IN FOOD SCIENCE & TECHNOLOGY
LA English
DT Review
DE Anthocyanins; Anti-obesity; Lipid metabolism; Biosynthesis
ID HIGH-FAT-DIET; RECOMBINANT ESCHERICHIA-COLI; GUT MICROBIOTA COMPOSITION;
   COMMON BAYBERRY CULTIVARS; BODY-WEIGHT GAIN; OXIDATIVE STRESS; METABOLIC
   SYNDROME; GENE-EXPRESSION; EFFICIENT PRODUCTION; ANTIOXIDANT ACTIVITY
AB Background: Obesity is a serious health problem and the cause for social and economic burdens. Currently, there is still no cure for obesity, while the investment of time and money for one is huge. Recent years, the possibility of developing natural products from fruits and vegetables with bioactivities into anti-disease agents has become a hot spot in research. Thus, anthocyanins are increasingly causing more attention, as they have been proved to show anti-obesity effects. Furthermore, recent advances in biosynthesis of anthocyanins in microorganisms have illustrated a promising way in producing these valuable compounds in large scales.
   Scope and approach: Anthocyanins have great importance in developing a cure for obesity and biosynthesis in microorganisms has high potential in their massive production. This review therefore highlights the recent advances in the anti-obesity effects of anthocyanins and their biosynthesis in microorganisms. We have comprehensively discussed the molecular mechanisms involved in the anti-obesity effects of anthocyanins, the physicochemical and physiological properties of anthocyanins, the suitability of anthocyanins in anti-obesity therapies as well as the possibility of biosynthesis in microorganisms in future application.
   Key findings and conclusions: Anthocyanins have shown anti-obesity effects through multiple mechanisms, and biosynthesis of anthocyanins in microorganisms could have extensive applications. Inhibiting lipid absorption, regulating lipid metabolism, increasing energy expenditure, suppressing food intake and regulating gut micro biota are major mechanisms involved. Moreover, anthocyanins are promising candidates in developing anti obesity therapies. Further studies are required to explore therapeutic uses of anthocyanins in treating obesity and application of biosynthesis of anthocyanins in microorganisms in industries.
C1 [Xie, Lianghua; Su, Hongming; Zheng, Xiaodong; Chen, Wei] Zhejiang Univ, Natl Engn Lab Intelligent Food Technol & Equipmen, Key Lab Agroprod Postharvest Handling,Fuli Inst F, Dept Food Sci & Nutr,Minist Agr,Zhejiang Key Lab, Hangzhou 310058, Zhejiang, Peoples R China.
   [Sun, Chongde] Zhejiang Univ, Zhejiang Prov Key Lab Hort Plant Integrat Biol, State Agr Minist Lab Hort Plant Growth Dev & Qual, Lab Fruit Qual Biol, Hangzhou 310058, Zhejiang, Peoples R China.
C3 Ministry of Agriculture & Rural Affairs; Zhejiang University; Zhejiang
   University
RP Chen, W (corresponding author), Zhejiang Univ, Dept Food Sci & Nutr, 866 Yuhangtang Rd, Hangzhou 310058, Zhejiang, Peoples R China.
EM zjuchenwei@zju.edu.cn
RI Su, Hongming/M-9431-2013; Chen, Wei/AAR-9817-2020; zheng,
   xiaodong/C-4050-2008
OI Su, Hongming/0000-0002-9847-1825; CHEN, WEI/0000-0002-2373-2437; Xie,
   Lianghua/0009-0004-1669-4593
FU Zhejiang Provincial Natural Science Foundation of China [LR18C200002];
   National Key Technology RAMP;D Program of China [2016YFD0401201];
   Fundamental Research Funds for the Central Universities [2017QNA6006]
FX This work was supported by Grants from Zhejiang Provincial Natural
   Science Foundation of China (LR18C200002), National Key Technology R&D
   Program of China (2016YFD0401201), and Fundamental Research Funds for
   the Central Universities (2017QNA6006).
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NR 105
TC 148
Z9 159
U1 10
U2 348
PU ELSEVIER SCIENCE LONDON
PI LONDON
PA 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND
SN 0924-2244
J9 TRENDS FOOD SCI TECH
JI Trends Food Sci. Technol.
PD FEB
PY 2018
VL 72
BP 13
EP 24
DI 10.1016/j.tifs.2017.12.002
PG 12
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA FW0DR
UT WOS:000424962100002
DA 2025-06-11
ER

PT J
AU Huang, CY
   Kuo, CH
   Lee, CH
AF Huang, Chun-Yung
   Kuo, Chia-Hung
   Lee, Chia-Hsin
TI Antibacterial and Antioxidant Capacities and Attenuation of Lipid
   Accumulation in 3T3-L1 Adipocytes by Low-Molecular-Weight Fucoidans
   Prepared from Compressional-Puffing-Pretreated Sargassum
   Crassifolium
SO MARINE DRUGS
LA English
DT Article
DE 3T3-L1 cells; antibacterial; antioxidant; lipid accumulation;
   low-molecular-weight fucoidan; Sargassum crassifolium
ID CONTAINING SULFATED POLYSACCHARIDES; OXYGEN SPECIES ROS; OXIDATIVE
   STRESS; BUTYLATED HYDROXYANISOLE; EXTRACTION METHODS; METABOLIC
   SYNDROME; PHENOLIC-COMPOUNDS; CELLS; DIFFERENTIATION; DEGRADATION
AB In this study, we extracted fucoidan from compressional-puffing-pretreated Sargassum crassifolium by hot water. The crude extract of fucoidan (SC) was degraded by various degradation reagents and four low-molecular-weight (LMW) fucoidans, namely SCO (degradation by hydrogen peroxide), SCA (degradation by ascorbic acid), SCOA (degradation by hydrogen peroxide + ascorbic acid), and SCH (degradation by hydrogen chloride) were obtained. The degradation reagents studied could effectively degrade fucoidan into LMW fucoidans, as revealed by intrinsic viscosity, agarose gel electrophoresis, and molecular weight analyses. These LMW fucoidans had higher uronic acid content and sulfate content than those of SC. It was found that SCOA exhibited antibacterial activity. All LMW fucoidans showed antioxidant activities as revealed by DPPH (2,2-diphenyl-1-picrylhydrazyl), ABTS (2,2-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt), and FRAP (ferric reducing antioxidant power) methods. Biological experiments showed that SC and SCOA had relatively high activity for the reversal of H2O2-induced cell death in 3T3-L1 adipocytes, and SCOA showed the highest effect on attenuation of lipid accumulation in 3T3-L1 adipocytes. Therefore, for the LMW fucoidans tested, SCOA showed antibacterial activity and had a high fucose content, high sulfate content, high activity for the reversal of H2O2-induced cell death, and a marked effect on attenuation of lipid accumulation. It can thus be recommended as a natural and safe antibacterial and anti-adipogenic agent for food, cosmetic, and nutraceutical applications.
C1 [Huang, Chun-Yung; Kuo, Chia-Hung; Lee, Chia-Hsin] Natl Kaohsiung Marine Univ, Dept Seafood Sci, 142 Haijhuan Rd, Kaohsiung 81157, Taiwan.
C3 National Kaohsiung University of Science & Technology
RP Huang, CY (corresponding author), Natl Kaohsiung Marine Univ, Dept Seafood Sci, 142 Haijhuan Rd, Kaohsiung 81157, Taiwan.
EM cyhuang@webmail.nkmu.edu.tw; chkuo@webmail.nkmu.edu.tw;
   j58675@yahoo.com.tw
RI Chen, Yung-Chung/GRY-3101-2022; Lee, Chang-Chun/M-1436-2016; Kuo,
   Chia-Hung/I-6058-2012
OI Kuo, Chia-Hung/0000-0003-3445-5663; Huang, Chun-Yung/0000-0001-9117-1013
FU Ministry of Science and Technology, Taiwan [MOST 106-2320-B-022-001]
FX This work was supported by a grant provided by the Ministry of Science
   and Technology (Grant No. MOST 106-2320-B-022-001), Taiwan, awarded to
   Chun-Yung Huang.
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NR 54
TC 38
Z9 39
U1 1
U2 35
PU MDPI AG
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1660-3397
J9 MAR DRUGS
JI Mar. Drugs
PD JAN
PY 2018
VL 16
IS 1
AR 24
DI 10.3390/md16010024
PG 18
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA FU8SN
UT WOS:000424125600024
PM 29324642
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Gatiatulina, ER
   Popova, EV
   Polyakova, VS
   Skalnaya, AA
   Agletdinov, EF
   Nikonorov, AA
   Skalny, AV
   Tinkov, AA
AF Gatiatulina, Eugenia R.
   Popova, Elizaveta V.
   Polyakova, Valentina S.
   Skalnaya, Anastasia A.
   Agletdinov, Eduard F.
   Nikonorov, Alexandr A.
   Skalny, Anatoly V.
   Tinkov, Alexey A.
TI Evaluation of tissue metal and trace element content in a rat model of
   non-alcoholic fatty liver disease using ICP-DRC-MS
SO JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
LA English
DT Article
DE Fatty liver; Obesity; Trace elements; Minerals; Insulin resistance
ID INSULIN-RESISTANCE; OXIDATIVE STRESS; COPPER CONCENTRATIONS; METABOLIC
   SYNDROME; HEPATIC IRON; IN-VIVO; OBESITY; NAFLD; DIET; DEFICIENCY
AB The primary objective of the study was to assess the level of metals and trace elements in liver, serum, and hair of rats with diet-induced non-alcoholic fatty liver disease (NAFLD) using inductively coupled plasma dynamic reaction cell mass spectrometer (ICP-DRC-MS). 56 female 3-months-old Wistar rats divided into two equal groups were fed either standard (10% calories from fat) or high-fat high-carbohydrate diet (60% calories from fat in chow and 10% sucrose solution) for 6 weeks. Serum was examined for insulin resistance markers, lipid profile, and alanine aminotransferase (ALT) activity. Liver histology was assessed after hematoxylin and eosin staining. Metal and trace element concentrations were assessed by means of ICP-DRC-MS. Overfed animals were characterized by higher values of morphometric parameters. Liver examination revealed large and small droplet steatosis, hepatocyte ballooning and necrosis, being characteristic for NAFLD. Animals with NAFLD were characterized by insulin resistance, atherogenic changes of lipid profile and increased ALT activity. Significantly decreased hepatic Co, Cu, I, Li, Mn, Se, Zn levels were observed in rats with NAFLD. At the same time, only hepatic Mn and Se levels remained decreased after adjustment for total protein. Overfed animals were characterized by significantly lower I, Li, and Mn levels in blood serum, whereas concentration of Co, Se, V, and Sr exceeded the control values. In general, the results of the study demonstrate that NAFLD significantly affects metal and trace element status in experimental animals. (C) 2016 Elsevier GmbH. All rights reserved.
C1 [Gatiatulina, Eugenia R.; Popova, Elizaveta V.; Nikonorov, Alexandr A.; Tinkov, Alexey A.] Orenburg State Med Univ, Dept Biochem, Sovetskaya St 6, Orenburg 460000, Russia.
   [Polyakova, Valentina S.] Orenburg State Med Univ, Dept Pathol Anat, Sovetskaya St 6, Orenburg 460000, Russia.
   [Skalnaya, Anastasia A.] Lomonosov Moscow State Univ, Fac Fundamental Med, Lomonosovsky Prospekt 31-5, Moscow 117192, Russia.
   [Agletdinov, Eduard F.] Bashkir State Med Univ, Cent Res Lab, Zaki Validi St 64-2, Ufa 450057, Russia.
   [Nikonorov, Alexandr A.; Skalny, Anatoly V.; Tinkov, Alexey A.] Orenburg State Univ, Inst Bioelementol, Russian Satellite Ctr Trace Element, Inst UNESCO, Pobedy Ave 13, Orenburg 460352, Russia.
   [Skalny, Anatoly V.; Tinkov, Alexey A.] Yaroslavl State Univ, Lab Biotechnol & Appl Bioelementol, Sovetskaya St 14, Yaroslavl 150000, Russia.
   [Skalny, Anatoly V.] All Russian Res Inst Med & Aromat Plants VILAR, Grina St 7, Moscow 117216, Russia.
   [Skalny, Anatoly V.; Tinkov, Alexey A.] RUDN Univ, Miklukho Maklai Str 6, Moscow 117198, Russia.
C3 Lomonosov Moscow State University; Bashkir State Medical University;
   Orenburg State University; Yaroslavl State University; All-Russian
   Research Institute of Medicinal & Aromatic Plants; Peoples Friendship
   University of Russia
RP Tinkov, AA (corresponding author), Yaroslavl State Univ, Lab Biotechnol & Appl Bioelementol, Sovetskaya St 14, Yaroslavl 150000, Russia.
EM tinkov.a.a@gmail.com
RI Nikonorova, Eugenia/AAQ-5445-2020; Polyakova, Valentina/AAE-7314-2019;
   Skalny, Anatoly/J-3953-2019; Tinkov, Alexey/H-5842-2016
OI Tinkov, Alexey/0000-0003-0348-6192; Popova,
   Elizabeth/0000-0001-6703-4756; Nikonorova, Eugenia/0000-0002-6360-2194
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NR 66
TC 21
Z9 22
U1 0
U2 36
PU ELSEVIER GMBH
PI MUNICH
PA HACKERBRUCKE 6, 80335 MUNICH, GERMANY
SN 0946-672X
J9 J TRACE ELEM MED BIO
JI J. Trace Elem. Med. Biol.
PY 2017
VL 39
BP 91
EP 99
DI 10.1016/j.jtemb.2016.08.007
PG 9
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA EF7JM
UT WOS:000390505900014
PM 27908430
DA 2025-06-11
ER

PT J
AU Li, JJ
   Wittert, GA
   Vincent, A
   Atlantis, E
   Shi, ZM
   Appleton, SL
   Hill, CL
   Jenkins, AJ
   Januszewski, AS
   Adams, RJ
AF Li, Joule J.
   Wittert, Gary A.
   Vincent, Andrew
   Atlantis, Evan
   Shi, Zumin
   Appleton, Sarah L.
   Hill, Catherine L.
   Jenkins, Alicia J.
   Januszewski, Andrzej S.
   Adams, Robert J.
TI Muscle grip strength predicts incident type 2 diabetes: Population-based
   cohort study
SO METABOLISM-CLINICAL AND EXPERIMENTAL
LA English
DT Article
DE Skeletal muscle; Lean mass; Dual energy X-ray absorptiometry; Muscle
   strength; Grip strength
ID BODY-COMPOSITION; SKELETAL-MUSCLE; INSULIN-RESISTANCE; METABOLIC
   SYNDROME; OLDER-ADULTS; SELF-REPORT; HEALTH; MASS; MEN; RISK
AB Objectives. To determine the longitudinal relationship of muscle mass and strength with incident type 2 diabetes, and previously unstudied mediating effects of testosterone and inflammation.
   Methods. Community-dwelling male participants (aged >= 35 years) of the Men Androgen Inflammation Lifestyle Environment and Stress (MAILES) Study underwent biomedical assessment in 2002-2006 and 2007-2010, including hand grip strength (dynamometer), testosterone and inflammatory markers. Body composition (dual-energy X-ray absorptiometry) was assessed at baseline only. Incident type 2 diabetes was defined as a self-reported doctor diagnosis, diabetes medication use, fasting plasma glucose >= 7.0 mmol/L, or glycated haemoglobin >= 6.5% (48 mmol/mol) at follow-up, that was not present at baseline.
   Results. Of n = 1632 men, incident type 2 diabetes occurred in 146 (8.9%). Muscle mass was not associated with incident type 2 diabetes. Grip strength was inversely associated with incident type 2 diabetes [unadjusted odds ratio (OR) per 5 kg: 0.87, 95% confidence interval (CI): 0.80-0.95; adjusted OR, 95% CI: 0.87, 0.78-0.97]. Arm muscle quality (grip strength divided by arm lean mass) was similarly associated with incident type 2 diabetes. Testosterone, IL-6 and TNF-alpha did not significantly mediate the associations. The population attributable fraction of type 2 diabetes from low grip strength was 27% (13-40%), assuming intervention could increase strength by 25%.
   Conclusions. Reduced muscle strength, but not reduced muscle mass, is a risk factor for incident type 2 diabetes in men. This is not mediated by testosterone or inflammation. Intervention could prevent a substantial proportion of disease. (C) 2016 Elsevier Inc. All rights reserved.
C1 [Li, Joule J.; Appleton, Sarah L.; Hill, Catherine L.; Adams, Robert J.] Univ Adelaide, Sch Med, Hlth Observ, Adelaide, SA 5005, Australia.
   [Li, Joule J.; Wittert, Gary A.; Vincent, Andrew; Appleton, Sarah L.] Univ Adelaide, Sch Med, Freemasons Fdn Ctr Mens Hlth, Adelaide, SA 5005, Australia.
   [Atlantis, Evan] Univ Western Sydney, Sch Nursing & Midwifery, Penrith, NSW 1797, Australia.
   [Shi, Zumin] Univ Adelaide, Sch Med, Populat Res & Outcome Studies, Adelaide, SA 5005, Australia.
   [Jenkins, Alicia J.; Januszewski, Andrzej S.] Univ Sydney, Sydney Med Sch, NHMRC Clin Trials Ctr, Sydney, NSW 2006, Australia.
C3 University of Adelaide; University of Adelaide; Western Sydney
   University; University of Adelaide; University of Sydney
RP Li, JJ (corresponding author), Univ Adelaide, Hlth Observ Basil Hetzel Inst, Discipline Med, Queen Elizabeth Hosp Campus,Woodville Rd, Woodville, SA 5011, Australia.
EM joule.li@adelaide.edu.au
RI wittert, gary/AAE-2398-2019; Li, Joule/D-5645-2014; Hill,
   Catherine/AAE-7152-2019; Appleton, Sarah/Y-5206-2019; Jenkins,
   Alicia/N-2482-2015; Januszewski, Andrzej/R-4299-2019; Atlantis,
   Evan/ABC-8075-2021; Adams, Robert/Z-3197-2019; Shi, Zumin/A-1093-2009;
   Appleton, Sarah/E-9149-2017
OI Li, Joule J/0009-0003-0230-8199; Shi, Zumin/0000-0002-3099-3299;
   Appleton, Sarah/0000-0001-7292-9714; Jenkins,
   Alicia/0000-0003-0583-3717; Wittert, Gary/0000-0001-6818-6065
FU National Health and Medical Research Council of Australia [627227];
   University of Adelaide; South Australian Department of Health; Florey
   Foundation; South Australian Premier's Science and Research Fund
FX The MAILES cohort study has been supported by the National Health and
   Medical Research Council of Australia (grant number 627227), the
   University of Adelaide, the South Australian Department of Health, the
   Florey Foundation, and the South Australian Premier's Science and
   Research Fund. The funders had no role in study design, data collection
   and analysis, decision to publish, or preparation of the manuscript.
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NR 37
TC 83
Z9 84
U1 0
U2 18
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0026-0495
EI 1532-8600
J9 METABOLISM
JI Metab.-Clin. Exp.
PD JUN
PY 2016
VL 65
IS 6
BP 883
EP 892
DI 10.1016/j.metabol.2016.03.011
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA DM1ZJ
UT WOS:000376145100009
PM 27173467
DA 2025-06-11
ER

PT J
AU Schwartz, SS
   Epstein, S
   Corkey, BE
   Grant, SFA
   Gavin, JR
   Aguilar, RB
AF Schwartz, Stanley S.
   Epstein, Solomon
   Corkey, Barbara E.
   Grant, Struan F. A.
   Gavin, James R., III
   Aguilar, Richard B.
TI The Time Is Right for a New Classification System for Diabetes:
   Rationale and Implications of the β-Cell-Centric Classification Schema
SO DIABETES CARE
LA English
DT Article
ID INCRETIN-BASED THERAPY; INSULIN-RESISTANCE; GUT MICROBIOTA;
   CARDIOVASCULAR OUTCOMES; DIPEPTIDYL PEPTIDASE-4; COMBINATION THERAPY;
   METABOLIC SYNDROME; GLYCEMIC CONTROL; OPEN-LABEL; TYPE-2
AB The current classification system presents challenges to the diagnosis and treatment of patients with diabetes mellitus (DM), in part due to its conflicting and confounding definitions of type 1 DM, type 2 DM, and latent autoimmune diabetes of adults (LADA). The current schema also lacks a foundation that readily incorporates advances in our understanding of the disease and its treatment. For appropriate and coherent therapy, we propose an alternate classification system. The beta-cell-centric classification of DM is a new approach that obviates the inherent and unintended confusions of the current system. The beta-cell-centric model presupposes that all DM originates from a final common denominator-the abnormal pancreatic beta-cell. It recognizes that interactions between genetically predisposed beta-cells with a number of factors, including insulin resistance (IR), susceptibility to environmental influences, and immune dysregulation/ inflammation, lead to the range of hyperglycemic phenotypes within the spectrum of DM. Individually or in concert, and often self-perpetuating, these factors contribute to beta-cell stress, dysfunction, or loss through at least 11 distinct pathways. Available, yet underutilized, treatments provide rational choices for personalized therapies that target the individual mediating pathways of hyperglycemia at work in any given patient, without the risk of drug-related hypoglycemia or weight gain or imposing further burden on the beta-cells. This article issues an urgent call for the review of the current DM classification system toward the consensus on a new, more useful system.
C1 [Schwartz, Stanley S.] Main Line Hlth, Wynnewood, PA 19096 USA.
   [Schwartz, Stanley S.] Univ Penn, Philadelphia, PA 19104 USA.
   [Epstein, Solomon] Mt Sinai Hosp, Dept Med, Div Endocrinol Diabet & Bone Dis, New York, NY 10029 USA.
   [Corkey, Barbara E.] Boston Univ, Sch Med, Dept Med, Boston, MA 02215 USA.
   [Grant, Struan F. A.] Univ Penn, Div Human Genet, Philadelphia, PA 19104 USA.
   [Grant, Struan F. A.] Univ Penn, Perelman Sch Med, Ctr Appl Genom, Dept Pediat, Philadelphia, PA 19104 USA.
   [Gavin, James R., III] Emory Univ, Sch Med, Atlanta, GA 30322 USA.
   [Aguilar, Richard B.] Diabet Nat, Sisters, OR USA.
C3 University of Pennsylvania; Icahn School of Medicine at Mount Sinai;
   Boston University; University of Pennsylvania; University of
   Pennsylvania; Emory University
RP Schwartz, SS (corresponding author), Main Line Hlth, Wynnewood, PA 19096 USA.
EM stschwar@gmail.com
RI Zhang, Huabing/ABD-6216-2020; Gavin, James/GWQ-6870-2022; Schwartz,
   S/I-9628-2019
OI Grant, Struan/0000-0003-2025-5302
FU National Institutes of Health (NIH) [R01 DK085212]; NIH [DK99618,
   DK56690, DK74778, DK35914]
FX S.S.S. and S.F.A.G. are partially supported by National Institutes of
   Health (NIH) grant R01 DK085212. S.F.A.G. holds the Daniel B. Burke
   Endowed Chair for Diabetes Research. B.E.C. is partially supported by
   NIH grants DK99618, DK56690, DK74778, and DK35914. No funding was
   received by any of authors for the work in the manuscript.
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NR 88
TC 218
Z9 248
U1 3
U2 52
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0149-5992
EI 1935-5548
J9 DIABETES CARE
JI Diabetes Care
PD FEB
PY 2016
VL 39
IS 2
BP 179
EP 186
DI 10.2337/dc15-1585
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA DB4XF
UT WOS:000368516200008
PM 26798148
OA Green Published
DA 2025-06-11
ER

PT J
AU Na, YK
   Hong, HS
   Lee, WK
   Kim, YH
   Kim, DS
AF Na, Yeon Kyung
   Hong, Hae Sook
   Lee, Won Kee
   Kim, Young Hun
   Kim, Dong Sun
TI Increased Methylation of Interleukin 6 Gene Is Associated with Obesity
   in Korean Women
SO MOLECULES AND CELLS
LA English
DT Article
DE BMI; GLUT4; IL6; Methylation; MSP; TFAM; TNF alpha
ID OBSTRUCTIVE SLEEP-APNEA; WHITE BLOOD-CELLS; DNA METHYLATION;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; PERIPHERAL-BLOOD; RISK-FACTORS;
   PROMOTER; CANCER; INFLAMMATION
AB Obesity is the fifth leading risk for death globally, and a significant challenge to global health. It is a common, complex, non-malignant disease and develops due to interactions between the genes and the environment. DNA methylation can act as a downstream effector of environmental signals; analysis of this process therefore holds substantial promise for identifying mechanisms through which genetic and environmental factors jointly contribute to disease risk. To assess the effects of excessive weight and obesity on gene-specific methylation levels of promoter regions, we determined the methylation status of four genes involved in inflammation and oxidative stress [interleukin 6 (IL6), tumor necrosis factor alpha (TNF alpha), mitochondrial transcription factor A (TFAM), and glucose transport 4 (GLUT4)] in blood cell-derived DNA from healthy women volunteers with a range of body mass indices (BMIs) by methylation-specific PCR. Interestingly, the samples from obese individuals (BMI >= 30 kg/m(2)) showed significantly increased hypermethylation for IL6 gene compared to normal weight (BMI >= 23 kg/m(2)) and overweight samples (23 kg/m(2) <= BMI < 30 kg/m(2)) (P = 0.034 and P = 0.026). However, there was no statistically significant difference in promoter methylation of the other 3 genes between each group. These findings suggest that aberrant DNA methylation of IL6 gene promoter may play an important role in the etiology and pathogenesis of obesity and IL6 methylation could be used as molecular biomarker for obesity risk assessment. Further studies are required to elucidate the potential mechanisms underlying this relationship.
C1 [Na, Yeon Kyung; Hong, Hae Sook] Kyungpook Natl Univ, Coll Nursing, Daegu 702422, South Korea.
   [Lee, Won Kee] Kyungpook Natl Univ, Dept Prevent Med, Daegu 702422, South Korea.
   [Kim, Young Hun; Kim, Dong Sun] Kyungpook Natl Univ, Dept Anat, Daegu 702422, South Korea.
   [Kim, Young Hun; Kim, Dong Sun] Kyungpook Natl Univ, Dept Anat, Sch Med, Plus KNU Biomed Convergence Program BK21, Daegu 702422, South Korea.
C3 Kyungpook National University (KNU); Kyungpook National University
   (KNU); Kyungpook National University (KNU); Kyungpook National
   University (KNU)
RP Kim, DS (corresponding author), Kyungpook Natl Univ, Dept Anat, Daegu 702422, South Korea.
EM doskim@knu.ac.kr
RI Kim, Dae/AAJ-7518-2021
OI Kim, Dong Sun/0000-0003-4943-0901
FU National Research Foundation - Korean Government (MOEHRD, Basic Research
   Promotion Fund) [NRF-2012R1A1A1004307]
FX This work was supported by a National Research Foundation Grant, which
   was funded by the Korean Government (MOEHRD, Basic Research Promotion
   Fund; grant number NRF-2012R1A1A1004307).
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NR 32
TC 30
Z9 35
U1 0
U2 4
PU KOREAN SOC MOLECULAR & CELLULAR  BIOLOGY
PI SEOUL
PA 635-4, YUCKSAM-DONG, GANGNAM-GU, SEOUL 135-703, SOUTH KOREA
SN 1016-8478
EI 0219-1032
J9 MOL CELLS
JI Mol. Cells
PD MAY 31
PY 2015
VL 38
IS 5
BP 452
EP 456
DI 10.14348/molcells.2015.0005
PG 5
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA CJ5VB
UT WOS:000355558800010
PM 25921605
OA hybrid, Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Dogan, BA
   Karakiliç, E
   Tuna, MM
   Arduç, A
   Berker, D
   Güler, S
AF Dogan, Bercem Aycicek
   Karakilic, Ersen
   Tuna, Mazhar Muslum
   Arduc, Ayse
   Berker, Dilek
   Guler, Serdar
TI Effect of androgen replacement therapy on atherosclerotic risk markers
   in young-to-middle-aged men with idiopathic hypogonadotropic
   hypogonadism
SO CLINICAL ENDOCRINOLOGY
LA English
DT Article
ID LOW SERUM TESTOSTERONE; METABOLIC SYNDROME; ENDOTHELIAL FUNCTION;
   CAROTID ATHEROSCLEROSIS; ENDOGENOUS TESTOSTERONE; CARDIOVASCULAR EVENTS;
   DEPRIVATION THERAPY; INSULIN-RESISTANCE; OXIDATIVE STRESS; SEX-HORMONES
AB ObjectiveIdiopathic hypogonadotropic hypogonadism is a rare disorder. This study evaluated the effect of androgen replacement therapy on atherosclerotic risk markers in young-to-middle-aged men with this disorder.
   Design and methodsForty-three male patients aged 30 (range: 24-39years) who were newly diagnosed with idiopathic hypogonadotropic hypogonadism and 20 age-, sex- and weight-matched controls (range: 26-39years) were included in the study. Androgen replacement therapy was given according to the Algorithm of Testosterone Therapy in Adult Men with Androgen Deficiency Syndromes (2010; Journal of Clinical Endocrinology and Metabolism, 95, 2536). The patients were assessed at a pretreatment visit and 3 and 6months after the treatment. Inflammatory markers and lipid parameters were evaluated. Endothelial function was assessed with brachial flow-mediated dilation of a brachial artery and high-resolution ultrasonography of the carotid intima-media thickness.
   ResultsThe carotid intima-media thickness (P<0001) was higher and the brachial flow-mediated diameter (P=0002) was lower in patients with idiopathic hypogonadotropic hypogonadism compared to the control subjects at the pretreatment visit. There was a negative correlation between the total testosterone level and carotid intima-media thickness (r=-0556, P=<0001). The carotid intima-media thickness and per cent flow-mediated diameter were significantly improved in the patient group 6months after the androgen replacement therapy (P=0002 and 0026, respectively).
   ConclusionsThis study indicated that low total testosterone levels can be considered a significant marker of atherosclerosis in patients with idiopathic hypogonadotropic hypogonadism and that androgen replacement therapy significantly reduces atherosclerotic risk markers in these patients after 6months.
C1 [Dogan, Bercem Aycicek] Darica Farabi State Hosp, Dept Endocrinol & Metab Dis, TR-41000 Darica, Kocaeli, Turkey.
   [Karakilic, Ersen; Berker, Dilek] Ankara Numune Training & Res Hosp, Dept Endocrinol & Metab Dis, Ankara, Turkey.
   [Tuna, Mazhar Muslum] Dicle Univ, Dept Endocrinol & Metab Dis, Diyarbakir, Turkey.
   [Arduc, Ayse] NIDDK, Dept Diabet, Endocrine & Obes Branch, NIH, Bethesda, MD 20892 USA.
   [Guler, Serdar] Hitit Univ, Dept Endocrinol & Metab Dis, Corum, Turkey.
C3 Darica Farabi State Hospital; Ankara Numune Training & Research
   Hospital; Dicle University; National Institutes of Health (NIH) - USA;
   NIH National Institute of Diabetes & Digestive & Kidney Diseases
   (NIDDK); Hitit University
RP Dogan, BA (corresponding author), Darica Farabi State Hosp, Dept Endocrinol & Metab, TR-41000 Darica, Kocaeli, Turkey.
EM bercemay@gmail.com
RI tuna, mazhar müslüm/Q-9568-2017; Karakılıç, Ersen/AAB-1936-2021
OI Guler, Serdar/0000-0003-2341-4794; AYCICEK, BERCEM/0000-0001-7085-5846;
   KARAKILIC, ERSEN/0000-0003-3590-2656
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NR 43
TC 15
Z9 16
U1 0
U2 10
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0300-0664
EI 1365-2265
J9 CLIN ENDOCRINOL
JI Clin. Endocrinol.
PD MAR
PY 2015
VL 82
IS 3
BP 422
EP 428
DI 10.1111/cen.12617
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA CC1QE
UT WOS:000350115600014
PM 25280063
DA 2025-06-11
ER

PT J
AU Diwan, V
   Small, D
   Kauter, K
   Gobe, GC
   Brown, L
AF Diwan, Vishal
   Small, David
   Kauter, Kate
   Gobe, Glenda C.
   Brown, Lindsay
TI CALL FOR PAPERS Sex and Gender Differences in Renal Physiology
SO AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
LA English
DT Article
DE chronic kidney disease; cardiovascular disease; inflammation; estrogen
   receptor-alpha; ERK1/2
ID CHRONIC KIDNEY-DISEASE; ESTROGEN-RECEPTOR; CARDIOVASCULAR-DISEASE;
   METABOLIC SYNDROME; ANGIOTENSIN-II; UP-REGULATION; CROSS-TALK; RATS;
   PROGRESSION; ESTRADIOL
AB Gender contributes to differences in incidence and progression of chronic kidney disease (CKD) and associated cardiovascular disease. To induce kidney damage in male and female Wistar rats (n = 12/group), a 0.25% adenine diet for 16 wk was used. Kidney function (blood urea nitrogen, plasma creatinine, proteinuria) and structure (glomerular damage, tubulointerstitial atrophy, fibrosis, inflammation); cardiovascular function (blood pressure, ventricular stiffness, vascular responses, echocardiography) and structure (cardiac fibrosis); plasma testosterone and estrogen concentrations; and protein expression for oxidative stress [heme oxygenase-1, inflammation (TNF-alpha), fibrosis (transforming growth factor-beta), ERK1/2, and estrogen receptor-alpha (ER-alpha)] were compared in males and females. Adenine-fed females had less decline in kidney function than adenine-fed males, although kidney atrophy, inflammation, and fibrosis were similar. Plasma estrogen concentrations increased and plasma testosterone concentrations decreased in adenine-fed males, with smaller changes in females. CKD-associated molecular changes in kidneys were more pronounced in males than females except for expression of ER-alpha in the kidney, which was completely suppressed in adenine-fed males but unchanged in adenine-fed females. Both genders showed increased blood pressure, ventricular stiffness, and cardiac fibrosis with the adenine diet. Cardiovascular changes with adenine were similar in males and females, except males developed concentric, and females eccentric cardiac hypertrophy. In hearts from adenine-fed male and female rats, expression of ER-alpha and activation of the ERK1/2 pathway were increased, in part explaining changes in cardiac hypertrophy. In summary, adenine-induced kidney damage may be increased in males due to the suppression of ER-alpha
C1 [Diwan, Vishal] Univ Queensland, Sch Biomed Sci, Brisbane, Qld, Australia.
   [Diwan, Vishal; Small, David; Gobe, Glenda C.] Univ Queensland, Translat Res Inst, Sch Med, Ctr Kidney Dis Res, Brisbane, Qld, Australia.
   [Kauter, Kate; Brown, Lindsay] Univ So Queensland, Sch Hlth Nursing & Midwifery, Toowoomba, Qld 4350, Australia.
C3 University of Queensland; University of Queensland; University of
   Southern Queensland
RP Brown, L (corresponding author), Univ So Queensland, Sch Hlth Nursing & Midwifery, Toowoomba, Qld 4350, Australia.
EM Lindsay.Brown@usq.edu.au
RI Small, David/S-1969-2019; Gobe, Glenda/G-2315-2010; Small, David
   M/E-6064-2019
OI Small, David M/0000-0003-3034-4747; Kauter, Kate/0000-0003-2470-9172
FU National Health and Medical Research Council of Australia
FX This project was partially funded by National Health and Medical
   Research Council of Australia.
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NR 49
TC 67
Z9 74
U1 0
U2 8
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 1931-857X
EI 1522-1466
J9 AM J PHYSIOL-RENAL
JI Am. J. Physiol.-Renal Physiol.
PD DEC 1
PY 2014
VL 307
IS 11
BP F1169
EP F1178
DI 10.1152/ajprenal.00676.2013
PG 10
WC Physiology; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology; Urology & Nephrology
GA AW0YW
UT WOS:000346018200001
PM 25209863
DA 2025-06-11
ER

PT J
AU Delzenne, NM
   Neyrinck, AM
   Cani, PD
AF Delzenne, Nathalie M.
   Neyrinck, Audrey M.
   Cani, Patrice D.
TI Modulation of the gut microbiota by nutrients with prebiotic properties:
   consequences for host health in the context of obesity and metabolic
   syndrome
SO MICROBIAL CELL FACTORIES
LA English
DT Article; Proceedings Paper
CT 10th Symposium on Lactic Acid Bacterium (LAB)
CY AUG 28-SEP 01, 2011
CL Egmond aan Zee, NETHERLANDS
ID DIET-INDUCED OBESITY; GLUCAGON-LIKE PEPTIDE-1; WEIGHT-LOSS; BACTERIAL
   TRANSLOCATION; INFLAMMATORY RESPONSE; INSULIN SENSITIVITY;
   ENERGY-METABOLISM; ADIPOSE-TISSUE; BIFIDOBACTERIA; MICE
AB The gut microbiota is increasingly considered as a symbiotic partner for the maintenance of health. The homeostasis of the gut microbiota is dependent on host characteristics (age, gender, genetic background ...), environmental conditions (stress, drugs, gastrointestinal surgery, infectious and toxic agents ...). Moreover, it is dependent on the day-to-day dietary changes. Experimental data in animals, but also observational studies in obese patients, suggest that the composition of the gut microbiota is a factor characterizing obese versus lean individuals, diabetic versus non diabetic patients, or patients presenting hepatic diseases such as non alcoholic steatohepatitis. Interestingly, the changes in the gut microbes can be reversed by dieting and related weight loss. The qualitative and quantitative changes in the intake of specific food components (fatty acids, carbohydrates, micronutrients, prebiotics, probiotics), have not only consequences on the gut microbiota composition, but may modulate the expression of genes in host tissues such as the liver, adipose tissue, intestine, muscle. This in turn may drive or lessen the development of fat mass and metabolic disturbances associated with the gut barrier function and the systemic immunity. The relevance of the prebiotic or probiotic approaches in the management of obesity in humans is supported by few intervention studies in humans up to now, but the experimental data obtained with those compounds help to elucidate novel potential molecular targets relating diet with gut microbes. The metagenomic and integrative metabolomic approaches could help elucidate which bacteria, among the trillions in human gut, or more specifically which activities/genes, could participate to the control of host energy metabolism, and could be relevant for future therapeutic developments.
C1 [Delzenne, Nathalie M.; Neyrinck, Audrey M.; Cani, Patrice D.] Catholic Univ Louvain, Louvain Drug Res Inst, Metab & Nutr Res Grp, Brussels, Belgium.
C3 Universite Catholique Louvain
RP Delzenne, NM (corresponding author), Catholic Univ Louvain, Louvain Drug Res Inst, Metab & Nutr Res Grp, Brussels, Belgium.
EM nathalie.delzenne@uclouvain.be
RI Neyrinck, Audrey/AAE-7929-2019; Delzenne, Nathalie/AAC-4628-2019; Cani,
   Patrice D./M-8055-2016
OI Cani, Patrice D./0000-0003-2040-2448; Neyrinck,
   Audrey/0000-0002-9435-3338; Delzenne, Nathalie/0000-0003-2115-6082
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NR 85
TC 169
Z9 192
U1 2
U2 19
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1475-2859
J9 MICROB CELL FACT
JI Microb. Cell. Fact.
PD AUG 30
PY 2011
VL 10
SU 1
AR S10
DI 10.1186/1475-2859-10-S1-S10
PG 11
WC Biotechnology & Applied Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Biotechnology & Applied Microbiology
GA 940SO
UT WOS:000303913600010
PM 21995448
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Colak, Y
   Ozturk, O
   Senates, E
   Tuncer, I
   Yorulmaz, E
   Adali, G
   Doganay, L
   Enc, FY
AF Colak, Yasar
   Ozturk, Oguzhan
   Senates, Ebubekir
   Tuncer, Ilyas
   Yorulmaz, Elif
   Adali, Gupse
   Doganay, Levent
   Enc, Feruze Yilmaz
TI SIRT1 as a potential therapeutic target for treatment of nonalcoholic
   fatty liver disease
SO MEDICAL SCIENCE MONITOR
LA English
DT Article
DE nonalcoholic fatty liver disease; sirtuin1 (SIRT1); treatment
ID SMALL-MOLECULE ACTIVATORS; PANCREATIC BETA-CELLS; TRANSCRIPTION FACTORS;
   INSULIN SENSITIVITY; HEPATIC STEATOSIS; GENE-EXPRESSION; PROTEIN SIR2;
   RESVERATROL; DEACETYLASE; STEATOHEPATITIS
AB Sirtuins are members of the silent information regulator 2 (Sir2) family, a group of Class III histone/protein deacetylases. There are 7 different sirtuins in mammals (SIRT1-7), of which SIRT1 is the best known and most studied. SIRT1 is responsible for the regulation of protein activation by means of deacetylating a variety of proteins that play important roles in the pathophysiology of metabolic diseases. Recently, it has been shown that SIRT1 plays key roles in the regulation of lipid and glucose homeostasis, control of insulin secretion and sensitivity, antiinflammatory effects, control of oxidative stress and the improvements in endothelial function that result due to increased mitochondrial biogenesis and beta-oxidation capacity.
   Nonalcoholic fatty liver disease (NAFLD) is currently the most common liver disease, and it has been accepted as the hepatic component of metabolic syndrome. Recent studies have shown that SIRT expression in the liver is significantly decreased in an NAFLD model of rats fed a high-fat diet, and moderate SIRT1 overexpression protects mice from developing NAFLD. In addition to resveratrol, a natural SIRT1 activator, small-molecule pharmacologic SIRT1 activators have positive effects on metabolic diseases. These effects are particularly promising in the case of diabetes mellitus, for which phase studies are currently being performed. With this information, we hypothesized that the pharmacologic activation of SIRT1, which has been implicated in the pathogenesis of NAFLD, will be a potential therapeutic target for treating NAFLD. In this paper, we review the metabolic effects of SIRT1 and its association with the pathophysiology of NAFLD.
C1 [Colak, Yasar; Ozturk, Oguzhan; Tuncer, Ilyas; Yorulmaz, Elif; Adali, Gupse; Doganay, Levent; Enc, Feruze Yilmaz] SB Goztepe Educ & Res Hosp, Dept Gastroenterol, TR-34730 Istanbul, Turkey.
   [Senates, Ebubekir] SB Haydarpasa Numune Educ & Res Hosp, Dept Gastroenterol, Istanbul, Turkey.
C3 Istanbul Goztepe Training & Research Hospital; Istanbul Haydarpasa
   Numune Training & Research Hospital
RP Colak, Y (corresponding author), SB Goztepe Educ & Res Hosp, Dept Gastroenterol, TR-34730 Istanbul, Turkey.
EM dryasarcolak@yahoo.com
RI Öztürk, Oğuzhan/JVN-9476-2024; enç, feruze/AAH-4205-2020; Tuncer,
   Ilyas/L-3470-2013; Senates, Ebubekir/G-6073-2010; Adali,
   Gupse/C-5726-2017; DOGANAY, HAMDI LEVENT/ABI-1538-2020
OI Adali, Gupse/0000-0003-2157-0304; DOGANAY, HAMDI
   LEVENT/0000-0002-2263-6689
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NR 70
TC 135
Z9 151
U1 0
U2 35
PU INT SCIENTIFIC LITERATURE, INC
PI SMITHTOWN
PA 361 FOREST LANE, SMITHTOWN, NY 11787 USA
SN 1643-3750
J9 MED SCI MONITOR
JI Med. Sci. Monitor
PD MAY
PY 2011
VL 17
IS 5
BP HY5
EP HY9
DI 10.12659/MSM.881749
PG 5
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 770QR
UT WOS:000291104100001
PM 21525818
OA Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Quintero, P
   Milagro, FI
   Campión, J
   Martínez, JA
AF Quintero, P.
   Milagro, F. I.
   Campion, J.
   Martinez, J. A.
TI Impact of oxygen availability on body weight management
SO MEDICAL HYPOTHESES
LA English
DT Article
ID GLUCAGON-LIKE PEPTIDE-1; TUMOR-NECROSIS-FACTOR; CHRONIC INTERMITTENT
   HYPOXIA; ADIPOSE-TISSUE HYPOXIA; HUMAN LEPTIN GENE; HIGH-ALTITUDE;
   NORMOBARIC HYPEROXIA; OXIDATIVE STRESS; TNF-ALPHA; INSULIN-RESISTANCE
AB Obesity is nowadays a major public health problem. The World Health Organization reported that globally 400 million adults are obese, and the situation seems to raise in the future. Furthermore, obesity is a major risk factor for a number of chronic diseases such as type 2 diabetes, cardiovascular diseases and the metabolic syndrome. Interestingly, several studies have reported that appetite suppression and body weight loss are frequently observed at high altitude. This observation has opened some possibilities for losing weight under hypoxia or living in altitude. Nevertheless, the triggering mechanisms for the decrease in energy intake in hypoxic conditions still remain unclear as well as the impact on body mass components. On the other hand, obese subjects often present a chronic inflammatory state on the adipose tissue that might have a strong relationship with onset and development of obesity-related diseases. Thus, it has been consistently reported that adipose tissue of obese subjects is poorly oxygenated and that this hypoxia state is a new potential risk factor for the chronic inflammation in obesity. In this sense, oxygen therapy is a common technique used in current medicine for the treatment of several diseases, while animal studies have demonstrated that treatment with hyperoxia produces some beneficial effects in different diseases related with lack of oxygen in several organs. In this article, we review the role of oxygen availability in body weight homeostasis and hypothesize the possible applicability of hypoxia and hyperoxia for the treatment of obesity and related disorders. (C) 2009 Elsevier Ltd. All rights reserved.
C1 [Quintero, P.; Milagro, F. I.; Campion, J.; Martinez, J. A.] Univ Navarra, Dept Nutr & Food Sci Physiol & Toxicol, Pamplona 31008, Spain.
C3 University of Navarra
RP Martínez, JA (corresponding author), Univ Navarra, Dept Nutr & Food Sci Physiol & Toxicol, C Irunlarrea 1, Pamplona 31008, Spain.
EM jalfmtz@unav.es
RI Milagro, Fermin/F-2315-2015; Martinez Hernandez, J Alfredo/K-8709-2014
OI Campion, Javier/0000-0002-6522-8271; Martinez Hernandez, J
   Alfredo/0000-0001-5218-6941; Milagro, Fermin I./0000-0002-3228-9916
FU Asociacion de Amigos Universidad de Navarra; Linea Especial [LE/97]
FX We are grateful to the Asociacion de Amigos Universidad de Navarra and
   to Linea Especial (LE/97) for financial support.
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NR 105
TC 58
Z9 61
U1 1
U2 20
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0306-9877
EI 1532-2777
J9 MED HYPOTHESES
JI Med. Hypotheses
PD MAY
PY 2010
VL 74
IS 5
BP 901
EP 907
DI 10.1016/j.mehy.2009.10.022
PG 7
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 599BY
UT WOS:000277886400035
PM 19913361
DA 2025-06-11
ER

PT J
AU Adolphe, JL
   Whiting, SJ
   Juurlink, BHJ
   Thorpe, LU
   Alcorn, J
AF Adolphe, Jennifer L.
   Whiting, Susan J.
   Juurlink, Bernhard H. J.
   Thorpe, Lilian U.
   Alcorn, Jane
TI Health effects with consumption of the flax lignan secoisolariciresinol
   diglucoside
SO BRITISH JOURNAL OF NUTRITION
LA English
DT Review
DE Secoisolariciresinol diglucoside; Flax lignans; Health benefits
ID BREAST-CANCER CELLS; SERUM ENTEROLACTONE CONCENTRATION;
   ISCHEMIA-REPERFUSION INJURY; PARTIALLY DEFATTED FLAXSEED; MAMMARY-GLAND
   STRUCTURES; ALPHA-LINOLENIC ACID; PURIFIED LIGNAN; HYPERCHOLESTEROLEMIC
   ATHEROSCLEROSIS; POSTMENOPAUSAL WOMEN; DIETARY FLAXSEED
AB Flaxseed is the richest source of the lignan secoisolariciresinol diglucoside (SDG). After ingestion, SDG is converted to secoisolariciresinol, which is further metabolised to the mammalian lignans enterodiol and enterolactone. A growing body of evidence suggests that SDG metabolites may provide health benefits due to their weak oestrogenic or anti-oestrogenic effects, antioxidant activity, ability to induce phase 2 proteins and/or inhibit the activity of certain enzymes, or by mechanisms yet unidentified. Human and animal studies identify the benefits of SDG consumption. SDG metabolites may protect against CVD and the metabolic syndrome by reducing lipid and glucose concentrations, lowering blood pressure, and decreasing oxidative stress and inflammation. Flax lignans may also reduce cancer risk by preventing pre-cancerous cellular changes and by reducing angiogenesis and metastasis. Thus, dietary SDG has the potential to decrease the incidence of several chronic diseases that result in significant morbidity and mortality in industrialised countries. The available literature, though, makes it difficult to clearly identify SDG health effects because of the wide variability in study methods. However, the current evidence suggests that a dose of at least 500 mg SDG/d for approximately 8 weeks is needed to observe positive effects on cardiovascular risk factors in human patients. Flaxseed and its lignan extracts appear to be safe for most adult populations, though animal studies suggest that pregnant women should limit their exposure. The present review discusses the potential health benefits of SDG in humans, with supporting evidence from animal studies, and offers suggestions for future research.
C1 [Adolphe, Jennifer L.; Whiting, Susan J.; Alcorn, Jane] Univ Saskatchewan, Coll Pharm & Nutr, Saskatoon, SK S7N 5C9, Canada.
   [Juurlink, Bernhard H. J.] Alfaisal Univ, Coll Med, Riyadh 11533, Saudi Arabia.
   [Thorpe, Lilian U.] Univ Saskatchewan, Coll Med, Saskatoon, SK S7N 5E5, Canada.
C3 University of Saskatchewan; Alfaisal University; University of
   Saskatchewan
RP Alcorn, J (corresponding author), Univ Saskatchewan, Coll Pharm & Nutr, 110 Sci Pl, Saskatoon, SK S7N 5C9, Canada.
EM jane.alcorn@usask.ca
FU Saskatchewan Health Research Foundation
FX The present study was supported in part through a Team Grant from the
   Saskatchewan Health Research Foundation.
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NR 87
TC 204
Z9 233
U1 2
U2 80
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1145
EI 1475-2662
J9 BRIT J NUTR
JI Br. J. Nutr.
PD APR 14
PY 2010
VL 103
IS 7
BP 929
EP 938
DI 10.1017/S0007114509992753
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 589QQ
UT WOS:000277168100001
PM 20003621
OA Bronze
DA 2025-06-11
ER

PT J
AU Piestrzeniewicz, K
   Luczak, K
   Goch, JH
AF Piestrzeniewicz, Katarzyna
   Luczak, Katarzyna
   Goch, Jan Henryk
TI Factors associated with C-reactive protein at the early stage of acute
   myocardial infarction in men
SO CARDIOLOGY JOURNAL
LA English
DT Article
DE C-reactive protein; adipokines; myocardial infarction
ID CORONARY-ARTERY-DISEASE; ADIPOSE-TISSUE; METABOLIC SYNDROME;
   PROINFLAMMATORY CYTOKINES; PERCUTANEOUS INTERVENTION; STRESS
   HYPERGLYCEMIA; RESISTIN; ADIPONECTIN; ATHEROSCLEROSIS; INFLAMMATION
AB Background: Elevation of C-reactive protein (CRP) is associated with acute coronary events. CRP is related to cardiovascular risk factors and adipokines. The aim of the study was to reveal the factors associated with elevated CRP levels in patients with ST-segment elevation acute myocardial infarction (STEMI). As there are sex-related differences in plasma levels of CRP and adipokines, our study was designed for males.
   Methods: Seventy men admitted within the initial 6 hours of STEMI were categorized into 4 groups according to the quartile of CRP. Clinical data and laboratory measurements were analyzed.
   Results: Anthropometric measurements, glucose at admission, resistin, and leptin were significantly higher, and adiponectin lower with the increase of CRP quartile. A significant positive correlation between CRP and body mass index, waist circumference, glucose at admission, resistin, and leptin and a negative relation of CRP to HDL-cholesterol and adiponectin were observed. In univariate logistic regression analysis, variables associated with a level of CRP above the fourth quartile were history of angina, obesity, diabetes, glucose at admission, resistin, leptin, and adiponectin, and independent predictors were glucose at admission and resistin. To predict the elevated CRP level the optimal cut-off for glucose at admission was 144 mg/dL (sensitivity 84%, specificity 86%) and for resistin was 21.5 mg/mL (sensitivity 79%, specificity 71%).
   Conclusions: Glucose at admission and resistin are independently associated with elevated levels of CRP in men during the early stage of STEMI. (Cardiol J 2009; 16: 36-42)
C1 [Piestrzeniewicz, Katarzyna; Luczak, Katarzyna; Goch, Jan Henryk] Dept Cardiol & Cardiac Surg, Clin Cardiol 1, PL-91425 Lodz, Poland.
RP Piestrzeniewicz, K (corresponding author), Dept Cardiol & Cardiac Surg, Clin Cardiol 1, 1-3 Sterlinga, PL-91425 Lodz, Poland.
EM kpiestrzeniewicz@tlen.pl
OI Piestrzeniewicz, Katarzyna/0000-0002-5415-2670
FU Medical University of Lodz research [502-11-205]
FX This study was supported by Medical University of Lodz research grant No
   502-11-205.The authors do not report any conflict of interest regarding
   this work.
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NR 37
TC 10
Z9 11
U1 0
U2 0
PU VIA MEDICA
PI GDANSK
PA UL SWIETOKRZYSKA 73, 80-180 GDANSK, POLAND
SN 1897-5593
EI 1898-018X
J9 CARDIOL J
JI Cardiol. J.
PD JAN
PY 2009
VL 16
IS 1
BP 36
EP 42
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 410ET
UT WOS:000263561000006
PM 19130414
DA 2025-06-11
ER

PT J
AU Dehnavi, RA
   de Roos, A
   Rabelink, TJ
   van Pelt, J
   Wensink, MJ
   Romijn, JA
   Tamsma, JT
AF Dehnavi, Reza Alizadeh
   de Roos, Albert
   Rabelink, Ton J.
   van Pelt, Johannes
   Wensink, Maarten J.
   Romijn, Johannes A.
   Tamsma, Jouke T.
TI Elevated CRP levels are associated with increased carotid
   atherosclerosis independent of visceral obesity
SO ATHEROSCLEROSIS
LA English
DT Article
DE CRP; Visceral obesity; Atherosclerosis; Visceral adipose tissue; 3T MRI
ID C-REACTIVE PROTEIN; INSULIN-RESISTANCE; METABOLIC SYNDROME; OXIDATIVE
   STRESS; RISK; INFLAMMATION; HEALTHY; MARKERS; ARTERY; SIZE
AB Background: Visceral obesity (VO) is associated with an increased risk of cardiovascular disease. Elevated C-reactive protein (CRP) levels are associated with VO and cardiovascular disease. After exploring the relation between CRP and VO, we aimed to evaluate the VO independent relation between CRP and carotid atherosclerosis.
   Methods and results: The prevalence of inflammation was evaluated in 439 male subjects with VO without type 2 diabetes and manifest cardiovascular disease. Waist circumference significantly correlated with CRP (r: 0.20, p < 0.001). However, 18.2% of patients in the waist circumference group 94-102 had elevated CRP levels while 9.6% of patients in the waist circumference group > 118 cm had low CRP levels. From the 439 subjects, 40 subjects were prospectively selected for MRI assessment of carotid atherosclerosis and visceral and subcutaneous adipose tissue distribution in a case-control setting matching for age and waist circumference. Twenty male subjects with age >50 years with CRP levels >2.5 mg/L (CRP+) were compared to 20 controls with CRP levels <1.8 rng/L (CRP-). Maximum vessel wall thickness in CRP+ was significantly higher both in the common carotid artery (15%, p<0.01) and the bulb region (18%, p<0.01). The distribution of fat in visceral and subcutaneous deposits was not significantly different between CRP+ and CRP-.
   Conclusion: Elevated CRP levels are associated with significantly increased maximum vessel wall thickness independent of VO and of MRI measured adipose tissue distribution, both in the common carotid artery and the carotid bulb. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
C1 [Dehnavi, Reza Alizadeh; Wensink, Maarten J.; Romijn, Johannes A.; Tamsma, Jouke T.] Leiden Univ, Med Ctr, Dept Gen Internal Med & Endocrinol, NL-2300 RC Leiden, Netherlands.
   [de Roos, Albert] Leiden Univ, Med Ctr, Dept Radiol, Leiden, Netherlands.
   [Rabelink, Ton J.] Leiden Univ, Med Ctr, Dept Nephrol, Leiden, Netherlands.
   [Rabelink, Ton J.] Leiden Univ, Med Ctr, Einthoven Lab, Leiden, Netherlands.
   [van Pelt, Johannes] Leiden Univ, Med Ctr, Dept Clin Chem, Leiden, Netherlands.
C3 Leiden University - Excl LUMC; Leiden University; Leiden University
   Medical Center (LUMC); Leiden University; Leiden University Medical
   Center (LUMC); Leiden University - Excl LUMC; Leiden University; Leiden
   University Medical Center (LUMC); Leiden University - Excl LUMC; Leiden
   University; Leiden University Medical Center (LUMC); Leiden University -
   Excl LUMC; Leiden University - Excl LUMC; Leiden University; Leiden
   University Medical Center (LUMC)
RP Dehnavi, RA (corresponding author), Leiden Univ, Med Ctr, Dept Gen Internal Med & Endocrinol, POB 9600, NL-2300 RC Leiden, Netherlands.
EM R.Alizadehdehnavi@lumc.nl
RI Rabelink, Ton/A-5316-2008
OI Rabelink, Ton/0000-0001-6780-5186
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NR 30
TC 23
Z9 26
U1 0
U2 4
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0021-9150
EI 1879-1484
J9 ATHEROSCLEROSIS
JI Atherosclerosis
PD OCT
PY 2008
VL 200
IS 2
BP 417
EP 423
DI 10.1016/j.atherosclerosis.2007.12.050
PG 7
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 368UJ
UT WOS:000260647700026
PM 18289549
DA 2025-06-11
ER

PT J
AU Michalik, L
   Feige, JN
   Gelman, L
   Pedrazzini, T
   Keller, H
   Desvergne, B
   Wahli, W
AF Michalik, L
   Feige, JN
   Gelman, L
   Pedrazzini, T
   Keller, H
   Desvergne, B
   Wahli, W
TI Selective expression of a dominant-negative form of peroxisome
   proliferator-activated receptor in keratinocytes leads to impaired
   epidermal healing
SO MOLECULAR ENDOCRINOLOGY
LA English
DT Article
ID THYROID-HORMONE RECEPTOR; RETINOIC ACID RECEPTOR; HUMAN INVOLUCRIN
   PROMOTER; NUCLEAR RECEPTORS; TRANSGENIC MICE; LIGAND-BINDING;
   PPAR-GAMMA; TRANSACTIVATION DOMAIN; METABOLIC SYNDROME;
   MOLECULAR-BIOLOGY
AB Many nuclear hormone receptors are involved in the regulation of skin homeostasis. However, their role in the epithelial compartment of the skin in stress situations, such as skin healing, has not been addressed yet. The healing of a skin wound after an injury involves three major cell types: immune cells, which are recruited to the wound bed; dermal fibroblasts; and epidermal and hair follicle keratinocytes. Our previous studies have revealed important but nonredundant roles of PPAR alpha and beta/delta in the reparation of the skin after a mechanical injury in the adult mouse. However, the mesenchymal or epithelial cellular compartment in which PPAR alpha and beta/delta play a role could not be determined in the null mice used, which have a germ line PPAR gene invalidation. In the present work, the role of PPAR alpha was studied in keratinocytes, using transgenic mice that express a PPAR alpha mutant with dominant-negative (dn) activity specifically in keratinocytes. This dn PPAR alpha lacks the last 13 C terminus amino acids, binds to a PPAR alpha agonist, but is unable to release the nuclear receptor corepressor and to recruit the coactivator p300. When selectively expressed in keratinocytes of transgenic mice, dn PPAR alpha Delta 13 causes a delay in the healing of skin wounds, accompanied by an exacerbated inflammation. This phenotype, which is similar to that observed in PPAR alpha null mice, strongly suggests that during skin healing, PPAR alpha is required in keratinocytes rather than in other cell types.
C1 Univ Lausanne, Ctr Integratif Genom, Natl Ctr Competence Res Frontiers Genet, CH-1015 Lausanne, Switzerland.
   Univ Lausanne, Dept Med, CH-1015 Lausanne, Switzerland.
C3 University of Lausanne; University of Lausanne
RP Univ Lausanne, Ctr Integratif Genom, Natl Ctr Competence Res Frontiers Genet, Genopode, CH-1015 Lausanne, Switzerland.
EM liliane.michalik@unil.ch; walter.wahli@unil.ch
RI Wahli, Walter/I-3194-2019; Desvergne, Beatrice/C-8892-2016
OI Michalik, Liliane/0000-0003-2963-2100; Desvergne,
   Beatrice/0000-0001-5483-288X; Gelman, Laurent/0000-0003-3277-3115
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NR 56
TC 27
Z9 30
U1 0
U2 3
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0888-8809
EI 1944-9917
J9 MOL ENDOCRINOL
JI Mol. Endocrinol.
PD SEP
PY 2005
VL 19
IS 9
BP 2335
EP 2348
DI 10.1210/me.2005-0068
PG 14
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 958MY
UT WOS:000231453600011
PM 15890673
OA Bronze
DA 2025-06-11
ER

PT J
AU He, YF
   Xiao, F
   Yi, B
   Lu, J
AF He, Yifei
   Xiao, Feng
   Yi, Bin
   Lu, Jin
TI Prevalence and associated factors of MAFLD in adults with type 2
   diabetes
SO PLOS GLOBAL PUBLIC HEALTH
LA English
DT Article
ID FATTY LIVER-DISEASE; TRANSIENT ELASTOGRAPHY; OXIDATIVE STRESS; FIBROSIS;
   STIFFNESS; SEVERITY
AB To estimate the prevalence and associated factors of hepatic steatosis and fibrosis in adults with type 2 diabetes (T2DM) in the United States.Data were retrieved from the 2017-March 2020 prepandemic cycle of the National Health and Nutritional Examination and Survey (NHANES). The study population included patients with T2DM. The controlled attenuation parameter (CAP) and liver stiffness measurement (LSM) were used to assess hepatic steatosis and fibrosis, respectively. A total of 1,290 T2DM patients were included, 85.2% (1044 patients) of whom presented with hepatic steatosis (CAP>248 dB/m). Among the 1044 T2DM patients with metabolically associated fatty liver disease (MAFLD), 29.5% developed hepatic fibrosis (LSM>8 kPa). Non-Hispanic black individuals (adjusted OR = 0.4008), BMI (adjusted OR = 1.1627), HbA1c (adjusted OR = 1.1450), TG (adjusted OR = 1.2347), HDL (adjusted OR = 0.4981), ALT (adjusted OR = 1.0227), AST (adjusted OR = 0.9396), and albumin (adjusted OR =1.7030) were independently associated with steatosis. Age (adjusted OR = 1.0300), female sex (adjusted OR = 0.6655), BMI (adjusted OR = 1.1324), AST (adjusted OR = 1.0483), and GGT (adjusted OR =1.0101) were independently associated with fibrosis. Heart failure was an independent factor associated with advanced fibrosis (adjusted OR = 1.9129) and cirrhosis (adjusted OR = 2.228). In the United States, hepatic steatosis is highly prevalent among T2DM patients, with 29.5% of these patients developing hepatic fibrosis. Some components of metabolic syndrome are related to hepatic steatosis and fibrosis. Moreover, heart failure is an independent factor associated with advanced fibrosis and cirrhosis.
C1 [He, Yifei; Lu, Jin] Naval Med Univ, Changhai Hosp, Dept Endocrinol, Shanghai, Peoples R China.
   [Xiao, Feng; Yi, Bin] Naval Med Univ, Eastern Hepatobiliary Surg Hosp, Dept Liver Transplantat, Shanghai, Peoples R China.
C3 Naval Medical University; Naval Medical University
RP Lu, J (corresponding author), Naval Med Univ, Changhai Hosp, Dept Endocrinol, Shanghai, Peoples R China.; Yi, B (corresponding author), Naval Med Univ, Eastern Hepatobiliary Surg Hosp, Dept Liver Transplantat, Shanghai, Peoples R China.
EM lujin-sh@139.com; billyyi11@163.com
FU Changhai Hospital (234 Discipline Climbing Plan) [2019YXK021]
FX Funding: This work was funded by a grant from Changhai Hospital (234
   Discipline Climbing Plan) Grant ID: 2019YXK021 to JL. The funders had no
   in study design, data collection and analysis, decision to publish, or
   preparation of the manuscript.
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NR 43
TC 0
Z9 0
U1 0
U2 0
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
EI 2767-3375
J9 PLOS GLOB PUBL HLTH
JI PLOS Glob. Public Health
PD DEC 30
PY 2024
VL 4
IS 12
AR e0003572
DI 10.1371/journal.pgph.0003572
PG 14
WC Public, Environmental & Occupational Health
WE Emerging Sources Citation Index (ESCI)
SC Public, Environmental & Occupational Health
GA W5M7P
UT WOS:001419020500001
PM 39775020
OA gold
DA 2025-06-11
ER

PT J
AU Su, M
   Tang, T
   Tang, WW
   Long, Y
   Wang, L
   Liu, ML
AF Su, Min
   Tang, Ting
   Tang, Weiwei
   Long, Yu
   Wang, Lin
   Liu, Meiling
TI Astragalus improves intestinal barrier function and immunity by acting
   on intestinal microbiota to treat T2DM: a research review
SO FRONTIERS IN IMMUNOLOGY
LA English
DT Review
DE Astragali Radix; active ingredients; type 2 diabetes mellitus;
   intestinal microbiota; immunity; metabolism
ID HIGH-FAT DIET; KAPPA-B PATHWAY; GUT-MICROBIOTA; INSULIN-RESISTANCE;
   METABOLIC SYNDROME; OXIDATIVE STRESS; IN-VITRO; IV; POLYSACCHARIDES;
   INFLAMMATION
AB Diabetes is a significant chronic endocrine/metabolism disorder that can result in a number of life-threatening consequences. According to research, the gut microbiota is strongly linked to the development of diabetes, making it a viable target for diabetes treatment. The intestinal microbiota affects intestinal barrier function, organism immunity, and thus glucose metabolism and lipid metabolism. According to research, a disruption in the intestinal microbiota causes a decrease in short-chain fatty acids (SCFAs), alters the metabolism of bile acids (BAs), branched-chain amino acids (BCAAs), lipopolysaccharide (LPS), and endotoxin secretion, resulting in insulin resistance, chronic inflammation, and the progression to type 2 diabetes mellitus (T2DM). Astragali Radix is a medicinal herb of the same genus as food that has been extensively researched for treating diabetes mellitus with promising results in recent years. Polysaccharides, saponins, flavonoids, and other components are important. Among them, Astragaloside has a role in protecting the cellular integrity of the pancreas and liver, can leading to alleviation of insulin resistance and reducing blood glucose and triglyceride (TC) levels; The primary impact of Astragalus polysaccharides (APS) on diabetes is a decrease in insulin resistance, encouragement of islet cell proliferation, and suppression of islet beta cell death; Astragali Radix flavonoids are known to enhance immunity, anti-inflammatory, regulate glucose metabolism and control the progression of diabetes. This study summarizes recent studies on Astragali Radix and its group formulations in the treatment of type 2 diabetes mellitus by modulating the intestinal microbiota.
C1 [Su, Min; Liu, Meiling] Changsha Med Univ, Hunan Key Lab Res & Dev Novel Pharmaceut Preparat, Changsha, Peoples R China.
   [Su, Min; Tang, Ting; Tang, Weiwei; Long, Yu; Wang, Lin; Liu, Meiling] Changsha Med Univ, Sch Basic Med, Dept Biochem & Mol Biol, Changsha, Peoples R China.
C3 Changsha Medical University; Changsha Medical University
RP Liu, ML (corresponding author), Changsha Med Univ, Hunan Key Lab Res & Dev Novel Pharmaceut Preparat, Changsha, Peoples R China.; Liu, ML (corresponding author), Changsha Med Univ, Sch Basic Med, Dept Biochem & Mol Biol, Changsha, Peoples R China.
EM 42187773@qq.com
RI Tang, Weiwei/AAK-6878-2021
FU This study was supported by Hunan Provincial Education Department
   Scientific Research Project: Hunan Education Bulletin (2019)
   No.353-19C0196.; Hunan Provincial Education Department Scientific
   Research Project: Hunan Education Bulletin
FX This study was supported by Hunan Provincial Education Department
   Scientific Research Project: Hunan Education Bulletin (2019)
   No.353-19C0196.
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NR 96
TC 25
Z9 28
U1 13
U2 57
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-3224
J9 FRONT IMMUNOL
JI Front. Immunol.
PD AUG 10
PY 2023
VL 14
AR 1243834
DI 10.3389/fimmu.2023.1243834
PG 12
WC Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology
GA W7VR2
UT WOS:001093671700001
PM 37638043
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Shulyatnikova, T
   Hayden, MR
AF Shulyatnikova, Tatyana
   Hayden, Melvin R.
TI Why Are Perivascular Spaces Important?
SO MEDICINA-LITHUANIA
LA English
DT Review
DE brain MRI; CADISIL; capillary rarefaction; cerebral small vessel
   disease; enlarged perivascular spaces; glymphatic system; impaired
   cognition; lacunes; neurodegeneration; white matter hyperintensities
ID VIRCHOW-ROBIN SPACES; SMALL VESSEL DISEASE; METABOLIC SYNDROME;
   ENDOTHELIAL DYSFUNCTION; INSULIN-RESISTANCE; COGNITIVE DECLINE; BRAIN;
   MRI; IMPAIRMENT; RAREFACTION
AB Perivascular spaces (PVS) and their enlargement (EPVS) have been gaining interest as EPVS can be visualized non-invasively by magnetic resonance imaging (MRI) when viewing T-2-weighted images. EPVS are most commonly observed in the regions of the basal ganglia and the centrum semiovale; however, they have also been identified in the frontal cortex and hippocampal regions. EPVS are known to be increased in aging and hypertension, and are considered to be a biomarker of cerebral small vessel disease (SVD). Interest in EPVS has been significantly increased because these PVS are now considered to be an essential conduit necessary for the glymphatic pathway to provide the necessary efflux of metabolic waste. Metabolic waste includes misfolded proteins of amyloid beta and tau that are known to accumulate in late-onset Alzheimer's disease (LOAD) within the interstitial fluid that is delivered to the subarachnoid space and eventually the cerebral spinal fluid (CSF). The CSF acts as a sink for accumulating neurotoxicities and allows clinical screening to potentially detect if LOAD may be developing early on in its clinical progression via spinal fluid examination. EPVS are thought to occur by obstruction of the PVS that associates with excessive neuroinflammation, oxidative stress, and vascular stiffening that impairs flow due to a dampening of the arterial and arteriolar pulsatility that aids in the convective flow of the metabolic debris within the glymphatic effluxing system. Additionally, increased EPVS has also been associated with Parkinson's disease and non-age-related multiple sclerosis (MS).
C1 [Shulyatnikova, Tatyana] Zaporizhzhia State Med Univ, Dept Pathol Anat & Forens Med, Mayakovsky Ave 26, UA-69035 Zaporizhzhia, Ukraine.
   [Hayden, Melvin R.] Univ Missouri, Sch Med, Diabet & Cardiovasc Dis Ctr, Dept Internal Med Endocrinol Diabet & Metab, One Hosp Dr, Columbia, MO 65211 USA.
C3 Zaporizhzhia State Medical University; University of Missouri System;
   University of Missouri Columbia
RP Hayden, MR (corresponding author), Univ Missouri, Sch Med, Diabet & Cardiovasc Dis Ctr, Dept Internal Med Endocrinol Diabet & Metab, One Hosp Dr, Columbia, MO 65211 USA.
EM shulyatnikova.tv@gmail.com; mrh29pete@gmail.com
OI Hayden, Melvin/0000-0001-5178-4245; Shulyatnikova,
   Tatyana/0000-0002-0196-9935
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NR 63
TC 18
Z9 19
U1 2
U2 6
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
SN 1010-660X
EI 1648-9144
J9 MEDICINA-LITHUANIA
JI Med. Lith.
PD MAY 10
PY 2023
VL 59
IS 5
AR 917
DI 10.3390/medicina59050917
PG 20
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA H6LO9
UT WOS:000997058200001
PM 37241149
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Onuh, JO
   Dawkins, NL
   Aluko, RE
AF Onuh, John O.
   Dawkins, Norma L.
   Aluko, Rotimi E.
TI Cardiovascular disease protective properties of blueberry polyphenols
   (Vaccinium corymbosum): a concise review
SO FOOD PRODUCTION PROCESSING AND NUTRITION
LA English
DT Review
DE Bioactivity; Antioxidant capacity; Hypertension; Inflammation;
   Atherosclerosis; Oxidative stress; Phytochemicals
ID SERUM ANTIOXIDANT STATUS; KILLER-CELL COUNTS; DOUBLE-BLIND;
   BLOOD-PRESSURE; ENDOTHELIAL FUNCTION; ARTERIAL STIFFNESS; VASCULAR
   FUNCTION; PLATELET-FUNCTION; ANTHOCYANIN SUPPLEMENTATION; STAGE
   1-HYPERTENSION
AB Increasing epidemiological evidence suggests inverse association between consumption of diets rich in fruits and vegetables and the incidence of cardiovascular diseases (CVD), metabolic syndrome disorders, certain types of cancer, neurodegenerative disorders, and other forms of human chronic diseases. This may be due to the contents of some bioactive phytochemicals, especially polyphenols, which are abundant in fruits and vegetables and have antioxidant effects. Berry fruits are reported to have the highest total antioxidant capacity (TAC) among fruits. They may protect against CVD and hypertension either directly or in tandem with other cellular mechanisms. Blueberry anthocyanins have been reported to exhibit cardiovascular protective health effects by preventing cholesterol-induced atherosclerosis, and reduction of oxidative and inflammatory damages to the endothelium through several mechanisms. Such mechanisms may involve suppressing the release of inflammatory mediators, protection against ischemic damage of the heart as well as cardiomyocyte survival, lower systolic and mean arterial pressures and renal nitrite content in addition to multiple other beneficial effects. However, several limitations in existing studies make it difficult to draw conclusions regarding the preventive effects of blueberries and other polyphenols-rich foods, especially as data supporting a causal relationship between direct antioxidant capacity and CVD are insufficient or limited. It is also unclear, which molecules exert this effect since few studies with isolated polyphenols have been conducted in addition to a lack of proper understanding of other mechanisms that may be involved. This review is, therefore aimed at discussing some of the current literature information on the cardiovascular protective effects of blueberries with suggestions for future research directions.
C1 [Onuh, John O.; Dawkins, Norma L.] Tuskegee Univ, Coll Agr Environm & Nutr Sci, Dept Food & Nutr Sci, 1200 W Montgomery Rd, Tuskegee, AL 36088 USA.
   [Aluko, Rotimi E.] Univ Manitoba, Dept Food & Human Nutr Sci, Winnipeg, MB R3T 2N2, Canada.
C3 Tuskegee University; University of Manitoba
RP Onuh, JO (corresponding author), Tuskegee Univ, Coll Agr Environm & Nutr Sci, Dept Food & Nutr Sci, 1200 W Montgomery Rd, Tuskegee, AL 36088 USA.
EM jonuh@tuskegee.edu
RI Aluko, Rotimi/HPG-2631-2023; Onuh, John/JRX-3218-2023
FU George Washington Carver Agricultural Experiment Station, Tuskegee
   University, Tuskegee, Alabama, USA
FX This work was supported by funding from the George Washington Carver
   Agricultural Experiment Station, Tuskegee University, Tuskegee, Alabama,
   USA.
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NR 78
TC 13
Z9 13
U1 1
U2 8
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
EI 2661-8974
J9 FOOD PROD PROCESS NU
JI Food Prod. Process. Nutr.
PD MAR 21
PY 2023
VL 5
IS 1
AR 27
DI 10.1186/s43014-023-00139-y
PG 18
WC Food Science & Technology
WE Emerging Sources Citation Index (ESCI)
SC Food Science & Technology
GA A7NL9
UT WOS:000956948700001
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Buawangpong, N
   Pinyopornpanish, K
   Phrommintikul, A
   Chindapan, N
   Devahastin, S
   Chattipakorn, N
   Chattipakorn, SC
AF Buawangpong, Nida
   Pinyopornpanish, Kanokporn
   Phrommintikul, Arintaya
   Chindapan, Nathamol
   Devahastin, Sakamon
   Chattipakorn, Nipon
   Chattipakorn, Siriporn C.
TI Increased plasma trimethylamine-N-oxide levels are associated
   with mild cognitive impairment in high cardiovascular risk elderly
   population
SO FOOD & FUNCTION
LA English
DT Article
ID MINI-MENTAL-STATE; GUT MICROBIOTA; DEPENDENT METABOLITE;
   ALZHEIMERS-DISEASE; OXIDATIVE STRESS; OLDER-ADULTS; TMAO; PATHWAY;
   CONTRIBUTES; MICE
AB Trimethylamine-N-oxide (TMAO) has been shown to be associated with cardiovascular (CV) disease and cognitive impairment. The association between early stages of cognitive impairment and TMAO in a high CV risk population has not been previously investigated. This study aimed to investigate the association between the plasma TMAO level and cognitive function in a population with a high risk of CV disease. Participants at a high risk of CV were included. The cognition was evaluated using the Montreal Cognitive Assessment. A score lower than 25 out of 30 was used to indicate mild cognitive impairment (MCI). Blood samples of all participants (n = 233) were collected to measure the plasma levels of TMAO and other metabolic parameters, including fasting blood sugar and lipid profiles. Logistic regression was used to evaluate the association between MCI and high plasma TMAO levels, adjusted for confounding factors. Of 233 patients, the mean age of patients in this study was 64 years old (SD 8.4). The median TMAO level was 4.31 mu M (IQR 3.95). The high TMAO level was an independent risk factor of MCI (aOR 2.36, 95% CI 1.02 to 5.47; p 0.046), when adjusted for age, gender, health care service scheme, smoking history, metabolic syndrome, and history of established CV events. The high TMAO level was associated with MCI, after adjustment for potential confounding factors. These findings demonstrate that plasma TMAO levels can serve for target prediction as an independent risk factor for MCI in this population.
C1 [Buawangpong, Nida; Pinyopornpanish, Kanokporn] Chiang Mai Univ, Fac Med, Dept Family Med, Chiang Mai 50200, Thailand.
   [Phrommintikul, Arintaya] Chiang Mai Univ, Fac Med, Dept Internal Med, Div Cardiol, Chiang Mai 50200, Thailand.
   [Chindapan, Nathamol] Siam Univ, Fac Sci, Dept Food Technol, Bangkok 10160, Thailand.
   [Devahastin, Sakamon] King Mongkuts Univ Technol Thonburi, Fac Engn, Dept Food Engn, Adv Food Processsing Rsesearch Lab, Bangkok 10140, Thailand.
   [Devahastin, Sakamon] Royal Soc Thailand, Acad Sci, Bangkok 10300, Thailand.
   [Chattipakorn, Nipon; Chattipakorn, Siriporn C.] Chiang Mai Univ, Fac Med, Cardiac Electrophysiol Res & Training Ctr, Neurophysiol Unit, Chiang Mai 50200, Thailand.
   [Chattipakorn, Nipon] Chiang Mai Univ, Fac Med, Dept Physiol, Cardiac Electrophysiol Unit, Chiang Mai 50200, Thailand.
   [Chattipakorn, Nipon; Chattipakorn, Siriporn C.] Chiang Mai Univ, Ctr Excellence Cardiac Electrophysiol Res, Chiang Mai 50200, Thailand.
   [Chattipakorn, Siriporn C.] Chiang Mai Univ, Fac Dent, Dept Oral Biol & Diagnost Sci, Chiang Mai 50200, Thailand.
C3 Chiang Mai University; Chiang Mai University; Siam University; King
   Mongkuts University of Technology Thonburi; Chiang Mai University;
   Chiang Mai University; Chiang Mai University; Chiang Mai University
RP Chattipakorn, SC (corresponding author), Chiang Mai Univ, Fac Med, Cardiac Electrophysiol Res & Training Ctr, Neurophysiol Unit, Chiang Mai 50200, Thailand.; Chattipakorn, SC (corresponding author), Chiang Mai Univ, Ctr Excellence Cardiac Electrophysiol Res, Chiang Mai 50200, Thailand.; Chattipakorn, SC (corresponding author), Chiang Mai Univ, Fac Dent, Dept Oral Biol & Diagnost Sci, Chiang Mai 50200, Thailand.
EM scchattipakorn@gmail.com; siriporn.c@cmu.ac.th
RI Chattipakorn, Nipon/AAJ-4049-2021; Pinyopornpanish,
   Kanokporn/AAJ-2556-2021; Davahastin, Sakamon/AAV-5374-2020;
   Phrommintikul, Arintaya/X-1881-2019
OI Chattipakorn, Siriporn/0000-0003-1677-7052; Chindapan,
   Nathamol/0000-0002-5490-5310; Devahastin, Sakamon/0000-0001-9582-1554
FU Office of the Permanent Secretary, Ministry of Higher Education,
   Science, Research, and Innovation, Thailand [RGNS 64 -066]; National
   Research Council of Thailand; Senior Research Scholar Grant from the
   Thailand Research Fund [RTA 6180008]; NSTDA Research Chair Grant from
   the National Science and Technology Development Agency Thailand; Chiang
   Mai University Center of Excellence Award, Thailand
FX This study was financially supported by the Office of the Permanent
   Secretary, Ministry of Higher Education, Science, Research, and
   Innovation, Thailand [grant number RGNS 64 -066] (to NB), the Senior
   Research Scholar Award from the National Research Council of Thailand
   (to SCC); the Senior Research Scholar Grant [grant number RTA 6180008]
   from the Thailand Research Fund (to SD); the NSTDA Research Chair Grant
   from the National Science and Technology Development Agency Thailand (to
   NC); and the Chiang Mai University Center of Excellence Award, Thailand
   (to NC).
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NR 94
TC 6
Z9 8
U1 0
U2 13
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PD OCT 3
PY 2022
VL 13
IS 19
BP 10013
EP 10022
DI 10.1039/d2fo02021a
EA SEP 2022
PG 10
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA 5B1HH
UT WOS:000850505800001
PM 36069253
DA 2025-06-11
ER

PT J
AU Riedy, DR
   MacPherson, AR
   Sabet, S
   Dautovich, ND
AF Riedy, Dana R.
   MacPherson, Ashley R.
   Sabet, Sahar
   Dautovich, Natalie D.
TI Examining negative affect, sleep duration, and using food to cope as
   predictors of weight in midlife women
SO JOURNAL OF BEHAVIORAL MEDICINE
LA English
DT Article
DE Weight; Emotions; Eating behavior; Sleep; Midlife women
ID MENOPAUSAL TRANSITION; DEPRESSIVE SYMPTOMS; METABOLIC SYNDROME;
   BODY-COMPOSITION; EATING BEHAVIOR; GAIN; HEALTH; ASSOCIATION;
   DISTURBANCE; VARIABILITY
AB Midlife women are vulnerable to developing obesity. Behavioral and psychosocial factors including sleep duration, stress eating, and negative emotionality are risk factors. However, little is known about the complex daily interplay between sleep, eating, emotion, and weight among midlife women. The current study examined how daily sleep, using food to cope, and negative emotionality are associated with weight using a daily process research design. An archival analysis was performed using the Midlife in the United States-II study (MIDUS II). The sample consisted of 489 midlife women (40-64 years of age). Variables included ecological momentary assessments of daily sleep duration, using food to cope, and negative affect (means and intraindividual variability) and a standardized measurement of BMI. Sleep duration variability was a significant predictor of BMI, albeit the model only accounted for .8% of the variance in BMI (b = .019, p < .05). In the final adjusted model, sleep duration variability, using food to cope, age, and physical activity were all significant predictors of BMI F(5, 559) = 21.503, p < .001, R-2 = .161, circle times R-2 = .024, p = .001. Variability in negative affect, mean sleep duration or negative affect and the interactions between sleep duration (mean, variability) and negative affect (mean, variability) were not significant. Greater variability in sleep duration and greater use of food to cope predicted higher BMI in this sample across age and physical activity levels. Results highlight that daily health and psychosocial factors play an important role in weight.
C1 [Riedy, Dana R.; MacPherson, Ashley R.; Sabet, Sahar; Dautovich, Natalie D.] Virginia Commonwealth Univ, Dept Psychol, 800 West Franklin St,POB 842018, Richmond, VA 23284 USA.
C3 Virginia Commonwealth University
RP Riedy, DR; MacPherson, AR (corresponding author), Virginia Commonwealth Univ, Dept Psychol, 800 West Franklin St,POB 842018, Richmond, VA 23284 USA.
EM schreibedr@vcu.edu; macphersona@vcu.edu
FU John D. and Catherine T. MacArthur Foundation Research Network on
   Successful Midlife Development; National Institute on Aging
   [P01-AG020166]
FX The MIDUS 1 study (Midlife in the U.S.) was supported by the John D. and
   Catherine T. MacArthur Foundation Research Network on Successful Midlife
   Development. The MIDUS 2 research was supported by a grant from the
   National Institute on Aging (P01-AG020166) to conduct a longitudinal
   follow-up of the MIDUS 1 investigation.
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NR 63
TC 0
Z9 0
U1 0
U2 6
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0160-7715
EI 1573-3521
J9 J BEHAV MED
JI J. Behav. Med.
PD DEC
PY 2022
VL 45
IS 6
BP 894
EP 903
DI 10.1007/s10865-022-00338-x
EA AUG 2022
PG 10
WC Psychology, Clinical
WE Social Science Citation Index (SSCI)
SC Psychology
GA 6H2ZE
UT WOS:000836752100002
PM 35933573
DA 2025-06-11
ER

PT J
AU Xin, CH
   Fan, HY
   Xie, J
   Hu, JC
   Sun, X
   Liu, QC
AF Xin, Caihong
   Fan, Huaying
   Xie, Jing
   Hu, Jingcheng
   Sun, Xin
   Liu, Qiuchen
TI Impact of Diabetes Mellitus on Lower Urinary Tract Symptoms in Benign
   Prostatic Hyperplasia Patients: A Meta-Analysis
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Article
DE diabetes mellitus; LUTS; benign prostatic hyperplasia; meta-analysis;
   lower urinary tract symptoms
ID OVERACTIVE BLADDER; METABOLIC SYNDROME; OXIDATIVE STRESS; MARKERS
AB Background: Benign prostatic hyperplasia (BPH) is a disease that causes lower urinary tract symptoms (LUTS), which are the most common urological problem in approximately one-third of the male population aged over 50 years. Some studies have suggested that diabetes may be a risk factor for the development of BPH. However, whether diabetes aggravates the LUTS of BPH patients is still controversial.& nbsp;Aim: To investigate the impact of diabetes mellitus on LUTS in BPH patients.& nbsp;Methods: A literature search was conducted using Web of Science, Embase, PubMed, and China National Knowledge Infrastructure literature databases. This meta-analysis was registered in PROSPERO (registration number: CRD 42020200794). Fixed- or random-effects models were used for analysis according to heterogeneity. The results of the systematic analysis are presented as weighted mean difference (WMD) with the corresponding 95% confidence intervals (CI).& nbsp;Results: In total, 1308 studies were retrieved from databases and 18 articles comprising 1685 cases and 4653 controls were selected for meta-analysis. The results of the meta-analysis showed that the International Prostate Symptom Score (IPSS) value and prostate volume of BPH patients with diabetes was significantly higher than that of BPH patients without diabetes.& nbsp;Conclusions: This systematic review is the first to evaluate the impact of diabetes mellitus on LUTS in BPH patients. The results of our meta-analysis support the hypothesis that LUTS in BPH patients is increased in patients with diabetes mellitus compared with controls, which suggests that physicians should pay more attention to BPH patients with diabetes mellitus.& nbsp;Systematic Review Registration: PROSPERO [https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=200794], identifier CRD 42020200794.
C1 [Xin, Caihong] Fourth Peoples Hosp Shenyang, Dept Endocrinol & Metab, Shenyang, Peoples R China.
   [Fan, Huaying; Xie, Jing; Hu, Jingcheng; Sun, Xin] Soochow Univ, Affiliated Hosp 1, Dept Endocrinol & Metab, Suzhou, Peoples R China.
   [Liu, Qiuchen] Soochow Univ, Affiliated Hosp 1, Dept Urol, Suzhou, Peoples R China.
C3 Soochow University - China; Soochow University - China
RP Sun, X (corresponding author), Soochow Univ, Affiliated Hosp 1, Dept Endocrinol & Metab, Suzhou, Peoples R China.; Liu, QC (corresponding author), Soochow Univ, Affiliated Hosp 1, Dept Urol, Suzhou, Peoples R China.
EM sunxin77@126.com; chosenkeer@163.com
RI Sun, Xin/AAF-4356-2020
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NR 38
TC 17
Z9 18
U1 0
U2 14
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD FEB 1
PY 2022
VL 12
AR 741748
DI 10.3389/fendo.2021.741748
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA ZC5XE
UT WOS:000757591900001
PM 35178024
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Chamulitrat, W
   Jansakun, C
   Li, HL
   Liebisch, G
AF Chamulitrat, Walee
   Jansakun, Chutima
   Li, Huili
   Liebisch, Gerhard
TI Rescue of Hepatic Phospholipid Remodeling Defect in
   iPLA2β-Null Mice Attenuates Obese but Not Non-Obese Fatty
   Liver
SO BIOMOLECULES
LA English
DT Review
DE PLA2G6; fatty liver; phospholipid remodeling; diet-induced obesity;
   morbidly obesity; choline and methionine deficiency
ID HIGH-THROUGHPUT QUANTIFICATION; DIET-INDUCED OBESITY;
   ENDOPLASMIC-RETICULUM STRESS; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   GENETIC PREDISPOSITION; INFLAMMATION MARKERS; CHOLESTERYL ESTER;
   DIABETES-MELLITUS; PREVENTS OBESITY
AB Polymorphisms of group VIA calcium-independent phospholipase A2 (iPLA(2)beta or PLA2G6) are positively associated with adiposity, blood lipids, and Type-2 diabetes. The ubiquitously expressed iPLA(2)beta catalyzes the hydrolysis of phospholipids (PLs) to generate a fatty acid and a lysoPL. We studied the role of iPLA(2)beta on PL metabolism in non-alcoholic fatty liver disease (NAFLD). By using global deletion iPLA(2)beta-null mice, we investigated three NAFLD mouse models; genetic Ob/Ob and long-term high-fat-diet (HFD) feeding (representing obese NAFLD) as well as feeding with methionine- and choline-deficient (MCD) diet (representing non-obese NAFLD). A decrease of hepatic PLs containing monounsaturated- and polyunsaturated fatty acids and a decrease of the ratio between PLs and cholesterol esters were observed in all three NAFLD models. iPLA(2)beta deficiency rescued these decreases in obese, but not in non-obese, NAFLD models. iPLA(2)beta deficiency elicited protection against fatty liver and obesity in the order of Ob/Ob (sic) HFD >> MCD. Liver inflammation was not protected in HFD NAFLD, and that liver fibrosis was even exaggerated in non-obese MCD model. Thus, the rescue of hepatic PL remodeling defect observed in iPLA(2)beta-null mice was critical for the protection against NAFLD and obesity. However, iPLA(2)beta deletion in specific cell types such as macrophages may render liver inflammation and fibrosis, independent of steatosis protection.
C1 [Chamulitrat, Walee; Jansakun, Chutima; Li, Huili] Univ Heidelberg Hosp, Dept Internal Med 4, Neuenheimer Feld 410, D-69120 Heidelberg, Germany.
   [Liebisch, Gerhard] Univ Regensburg, Inst Clin Chem & Lab Med, Franz Josef Strauss Allee 11, D-93053 Regensburg, Germany.
C3 Ruprecht Karls University Heidelberg; University of Regensburg
RP Chamulitrat, W (corresponding author), Univ Heidelberg Hosp, Dept Internal Med 4, Neuenheimer Feld 410, D-69120 Heidelberg, Germany.
EM Walee.Chamulitrat@med.uni-heidelberg.de;
   Chutima.Jansakun@med.uni-heidelberg.de; Huili.Li@med.uni-heidelberg.de;
   gerhard.liebisch@klinik.uni-regensburg.de
RI Liebisch, Gerhard/G-6130-2010; Jansakun, Chutima/IZP-7394-2023
OI Chamulitrat, Walee/0000-0002-5999-7664; Jansakun,
   Chutima/0000-0002-7892-4436
FU Deutsche Forschungsgemeinschaft [CH288/6-1, CH288/6-2]
FX This research was funded by Deutsche Forschungsgemeinschaft (CH288/6-1
   and CH288/6-2).
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NR 146
TC 9
Z9 10
U1 0
U2 11
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2218-273X
J9 BIOMOLECULES
JI Biomolecules
PD SEP
PY 2020
VL 10
IS 9
AR 1332
DI 10.3390/biom10091332
PG 25
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA OF8QF
UT WOS:000581464100001
PM 32957701
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Yu, J
   Liu, HB
   He, SL
   Li, PP
   Ma, CX
   Ma, ML
   Liu, YW
   Lv, L
   Ping, F
   Zhang, HB
   Li, W
   Sun, Q
   Xu, LL
   Li, YX
AF Yu, Jie
   Liu, Haibin
   He, Shuli
   Li, Pingping
   Ma, Chunxiao
   Ma, Minglei
   Liu, Yiwen
   Lv, Lu
   Ping, Fan
   Zhang, Huabing
   Li, Wei
   Sun, Qi
   Xu, Lingling
   Li, Yuxiu
TI Dietary Magnesium Intake and Leukocyte Telomere Attrition in Adults: The
   Regulatory Role of Serum Tumor Necrosis Factor α
SO MEDIATORS OF INFLAMMATION
LA English
DT Article
ID METABOLIC SYNDROME; MUSCLE MASS; POPULATION; CALCIUM
AB Objectives. In this study, we assessed the effects of dietary magnesium on leukocyte telomere length (LTL). Designs. The current cross-sectional analysis was based on data collected within a type 2 diabetes project. Settings. Dietary magnesium intake is associated with peripheral blood leukocyte telomere length (LTL). However, few epidemiological studies have evaluated the effects of magnesium on LTL in the clinical setting. Participants. This cross-sectional analysis included 467 participants (34.8% men). Measurements. Serum blood lipid profile, HbA1c, oxidative stress, and proinflammatory mediator levels were measured. Detailed dietary data were obtained using a 24 h food recall. LTL was assessed using a real-time PCR assay. Regression models and simple regulatory models were used for data analysis. Results. There was an inverse relationship between dietary magnesium and LTL (P<0.001), with a between-extreme-quarter difference of -0.55. Conversely, there was a positive relationship between dietary magnesium and serum tumor necrosis factor (TNF) alpha, with an interquarter difference of 3.79 pmol/mL (P for trend=0.006). Multivariate regression analysis revealed that the odds ratios (ORs) for shorter LTL and higher serum TNF alpha increased with magnesium intake, and the ORs of the differences between extreme quartiles were 2.60 (95% confidence interval (CI): 1.31-5.36; P=0.003) and 1.98 (95% CI: 1.09-3.59; P=0.008). There was a direct negative effect of dietary magnesium intake on LTL (B=-0.002; P=0.001), which appeared to be indirectly influenced by TNF alpha (-0.002 to -0.0005). Conclusions. Dietary magnesium intake may be a critical component of the cellular aging process, and its effect could be partly mediated by TNF alpha.
C1 [Yu, Jie; Ma, Minglei; Liu, Yiwen; Lv, Lu; Ping, Fan; Zhang, Huabing; Li, Wei; Sun, Qi; Xu, Lingling; Li, Yuxiu] Peking Union Med Coll Hosp, Dept Endocrinol, Key Lab Endocrinol, Minist Hlth, Beijing 100730, Peoples R China.
   [Liu, Haibin] Capital Med Univ, Dept Basic Physiol, Hlth Sch, Beijing, Peoples R China.
   [He, Shuli] Peking Union Med Coll Hosp, Dept Nutr, Beijing 100730, Peoples R China.
   [Li, Pingping] Chinese Acad Med Sci & Peking Union Med Coll, Inst Mat Medial, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China.
   [Ma, Chunxiao] State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China.
C3 Chinese Academy of Medical Sciences - Peking Union Medical College;
   Peking Union Medical College Hospital; Capital Medical University;
   Chinese Academy of Medical Sciences - Peking Union Medical College;
   Peking Union Medical College Hospital; Chinese Academy of Medical
   Sciences - Peking Union Medical College; Peking Union Medical College
RP Xu, LL; Li, YX (corresponding author), Peking Union Med Coll Hosp, Dept Endocrinol, Key Lab Endocrinol, Minist Hlth, Beijing 100730, Peoples R China.
EM llxuwsh@163.com; liyuxiu@medmail.com.cn
RI Li, Wei/JDD-4293-2023; Zhang, Huabing/ABD-6216-2020; Li,
   pingping/JPW-9278-2023; Yu, Jie/HHC-4315-2022; Li, Yuxiu/AAE-1202-2022;
   Ma, Minglei/HPG-8975-2023
OI Li, Wei/0000-0002-3332-1287; Ma, Minglei/0000-0003-4906-2352
FU CAMS Innovation Fund for Medical Sciences (CIFMS) [CIFMS2016-I2M-4-001]
FX The authors would like to thank all of the participants in this study.
   We would like to thank AJE (https://www.aje.cn) for English language
   editing. This project was supported by CAMS Innovation Fund for Medical
   Sciences (CIFMS) (CIFMS2016-I2M-4-001).
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NR 22
TC 9
Z9 10
U1 0
U2 1
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 0962-9351
EI 1466-1861
J9 MEDIAT INFLAMM
JI Mediat. Inflamm.
PD MAY 22
PY 2020
VL 2020
AR 7610436
DI 10.1155/2020/7610436
PG 6
WC Cell Biology; Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Immunology
GA LU7SE
UT WOS:000537949800002
PM 32565730
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Sepandar, F
   Daneshpazhooh, M
   Djalali, M
   Mohammadi, H
   Yaghubi, E
   Fakhri, Z
   Tavakoli, H
   Ghaedi, E
   Keshavarz, A
   Zarei, M
   Shahrbaf, MA
   Ghandi, N
   Darand, M
   Javanbakht, MH
AF Sepandar, Farnaz
   Daneshpazhooh, Maryam
   Djalali, Mahmoud
   Mohammadi, Hamed
   Yaghubi, Elham
   Fakhri, Zahra
   Tavakoli, Hajar
   Ghaedi, Ehsan
   Keshavarz, Ali
   Zarei, Mahnaz
   Shahrbaf, Mohammad Amin
   Ghandi, Narges
   Darand, Mina
   Javanbakht, Mohamad Hassan
TI The effect of l-carnitine supplementation on serum levels of omentin-1,
   visfatin and SFRP5 and glycemic indices in patients with pemphigus
   vulgaris: A randomized, double-blind, placebo-controlled clinical trial
SO PHYTOTHERAPY RESEARCH
LA English
DT Article
DE adipokines; carnitine; cytokines; glycemic index; pemphigus vulgaris
ID TYPE-2 DIABETES-MELLITUS; CORONARY-ARTERY-DISEASE; INSULIN-RESISTANCE;
   METABOLIC SYNDROME; OXIDATIVE STRESS; ADIPOSE-TISSUE; TREATMENT OPTIONS;
   MANAGEMENT; INFLAMMATION; ASSOCIATION
AB Pemphigus vulgaris (PV) is a chronic autoimmune disorder with potentially fatal outcomes. The aim of this study was to investigate the effect of l-carnitine (LC) on secreted frizzled-related protein-5 (SFRP5), omentin, visfatin, and glycemic indices in PV patients under corticosteroid treatment. In this randomized, double-blind, placebo-controlled clinical trial, 52 patients with PV were divided randomly into two groups to receive 2 g of LC or a placebo for 8 weeks. Serum levels of SFRP5, omentin, visfatin, and also glycemic indices were evaluated at the baseline and end of the study. LC supplementation significantly decreased the serum level of visfatin (95% CI [-14.718, -0.877], p = .05) and increased the serum levels of SFRP5 (95%CI [1.637, 11.380], p < .006) and omentin (95% CI [9.014, 65.286], p < .01). However, LC supplementation had no significant effects on the serum levels of glycemic factors such as insulin (95% CI [-1.125, 3.056], p = .426), fasting blood sugar (95% CI [-4.743, 3.642], p = .894), homeostatic model assessment of insulin resistance (95% CI [-0.305, 0.528], p = .729), and quantitative insulin-sensitivity check index (95% CI [-0.016, -0.010], p = .81). LC supplementation decreased visfatin serum level and increased omentin-1 and SFRP5 serum levels in patients with PV. However, it has no significant effect on the serum levels of insulin and glycemic indices.
C1 [Sepandar, Farnaz; Djalali, Mahmoud; Yaghubi, Elham; Fakhri, Zahra; Tavakoli, Hajar; Ghaedi, Ehsan; Zarei, Mahnaz; Javanbakht, Mohamad Hassan] Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Cellular & Mol Nutr, Tehran, Iran.
   [Daneshpazhooh, Maryam; Ghandi, Narges] Univ Tehran Med Sci, Dept Dermatol, Autoimmune Bullous Dis Res Ctr, Tehran, Iran.
   [Keshavarz, Ali] Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Clin Nutr, Tehran, Iran.
   [Shahrbaf, Mohammad Amin] Shahid Beheshti Univ Med Sci, Fac Med, Tehran, Iran.
   [Darand, Mina] Shahid Beheshti Univ Med Sci, Fac Nutr Sci & Food Technol, Natl Nutr & Food Technol Res Inst, Student Res Comm, Tehran, Iran.
   [Mohammadi, Hamed] Isfahan Univ Med Sci, Sch Nutr & Food Sci, Dept Clin Nutr, Food Secur Res Ctr, Esfahan, Iran.
C3 Tehran University of Medical Sciences; Tehran University of Medical
   Sciences; Tehran University of Medical Sciences; Shahid Beheshti
   University Medical Sciences; Shahid Beheshti University Medical
   Sciences; Isfahan University of Medical Sciences
RP Javanbakht, MH (corresponding author), Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Cellular & Mol Nutr, Tehran, Iran.
EM mhjavan2001@yahoo.com
RI Mohammadi, Hamed/Q-3166-2019; Daneshpazhooh, Maryam/B-9512-2018; fakhri,
   zahra/HPD-2600-2023; Ghandi, Narges/AAT-3395-2020
OI Ghaedi, Ehsan/0000-0003-4095-1591; fakhri, zahra/0000-0002-8044-2233; ,
   mina/0000-0003-2636-0963
FU Tehran University of Medical Sciences (TUMS) [29534]
FX This work was supported by the foundation (No. 29534) from Tehran
   University of Medical Sciences (TUMS).
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NR 65
TC 7
Z9 7
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0951-418X
EI 1099-1573
J9 PHYTOTHER RES
JI Phytother. Res.
PD APR
PY 2020
VL 34
IS 4
BP 859
EP 866
DI 10.1002/ptr.6568
EA DEC 2019
PG 8
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA LI0PX
UT WOS:000503035400001
PM 31849123
DA 2025-06-11
ER

PT J
AU Ionescu, MI
AF Ionescu, Mihaela Ileana
TI Adenylate Kinase: A Ubiquitous Enzyme Correlated with Medical Conditions
SO PROTEIN JOURNAL
LA English
DT Review
DE Adenylate kinase; Nucleotide metabolism; Phosphotransfer enzymes;
   AMP-activated protein kinase; Adenine nucleotide; Homeostasis
ID MITOCHONDRIAL ENERGY-METABOLISM; ESCHERICHIA-COLI; PROTEIN; AMP;
   IDENTIFICATION; DEFICIENCY; MUSCLE; CELLS; DETERMINANTS; DEREGULATION
AB Adenylate kinase is a small, usually monomeric, enzyme found in every living thing due to its crucial role in energetic metabolism. This paper outlines the most relevant data about adenylate kinases isoforms, and the connection between dysregulation or mutation of human adenylate kinase and medical conditions. The following datadases were consulted: National Centre for Biotechnology Information, Protein Data Bank, and Mouse Genomic Informatics. The SmartBLAST tool, EMBOSS Needle Program, and Clustal Omega Program were used to analyze the best protein match, and to perform pairwise sequence alignment and multiple sequence alignment. Human adenylate kinase genes are located on different chromosomes, six of them being on the chromosomes 1 and 9. The adenylate kinases' intracellular localization and organ distribution explain their dysregulation in many diseases. The cytosolic isoenzyme 1 and the mitochondrial isoenzyme 2 are the main adenylate kinases that are integrated in the vast network of inflammatory modulators. The cytosolic isoenzyme 5 is correlated with limbic encephalitis and Leu673Pro mutation of the isoenzyme 7 leads to primary male infertility due to impairment of the ciliary function. The impairment of the mitochondrial isoenzymes 2 and 4 is demonstrated in neuroblastoma or glioma. The adenylate kinases are disease modifier that can assess the risk of diseases where oxidative stress plays a crucial role in pathogenesis like metabolic syndrome or neurodegenerative diseases. Because adenylate kinases has ATP as substrate, they are integrated in the global network of energetic process of any organism therefore are valid target for new pharmaceutical compounds.
C1 [Ionescu, Mihaela Ileana] Iuliu Hatieganu Univ Med & Pharm, Fac Med, Dept Microbiol, 6 Louis Pasteur, Cluj Napoca 400349, Romania.
   [Ionescu, Mihaela Ileana] Cty Emergency Clin Hosp, Cluj Napoca, Romania.
C3 Iuliu Hatieganu University of Medicine & Pharmacy
RP Ionescu, MI (corresponding author), Iuliu Hatieganu Univ Med & Pharm, Fac Med, Dept Microbiol, 6 Louis Pasteur, Cluj Napoca 400349, Romania.; Ionescu, MI (corresponding author), Cty Emergency Clin Hosp, Cluj Napoca, Romania.
EM mionescu@umfcluj.ro
RI Ionescu, Mihaela/S-9516-2017
OI Ionescu, Mihaela Ileana/0000-0002-8019-118X
FU Ministery of Research and Innovation, CNCS - UEFISCDI, within PNCDI III
   [PN-III-P4-ID-PCCF-2016-0016]
FX This work is dedicated to the memory of Professor Dr. Octavian Barzu, my
   mentor in the study of nucleoside monophosphate kinases. This work was
   supported by a grant of Ministery of Research and Innovation, CNCS -
   UEFISCDI, project number PN-III-P4-ID-PCCF-2016-0016, within PNCDI III.
   The author would like to thank the referees for their generous and
   useful comments that have greatly improved the manuscript.
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NR 87
TC 35
Z9 39
U1 3
U2 53
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1572-3887
EI 1573-4943
J9 PROTEIN J
JI Protein J.
PD APR
PY 2019
VL 38
IS 2
BP 120
EP 133
DI 10.1007/s10930-019-09811-0
PG 14
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA HV8HV
UT WOS:000466223300002
PM 30666486
OA Bronze
DA 2025-06-11
ER

PT J
AU Tan, M
   Mamun, A
   Kitzman, H
   Dodgen, L
AF Tan, Marissa
   Mamun, Abdullah
   Kitzman, Heather
   Dodgen, Leilani
TI LONGITUDINAL CHANGES IN ALLOSTATIC LOAD DURING A RANDOMIZED
   CHURCH-BASED, LIFESTYLE INTERVENTION IN AFRICAN AMERICAN WOMEN
SO ETHNICITY & DISEASE
LA English
DT Article
DE Lifestyle Intervention; Allostatic Load; Health Behaviors; Church-based
   Program
ID PHYSICAL-ACTIVITY; NEIGHBORHOOD POVERTY; SOCIOECONOMIC-STATUS; METABOLIC
   SYNDROME; HEALTH; ADULTS; RISK; REDUCTION; STRENGTH; STRESS
AB Introduction: African American (AA) women have disproportionately higher risk of cardiovascular disease than White women, which may be explained by the uniquely higher allostatic load (AL) found in M women. No studies have tested the effect of lifestyle interventions on AL in M women. Our objectives were to assess the change in allostatic load following a lifestyle intervention and explore the roles of lifestyle behaviors and socioeconomic factors on allostatic load change.
   Methods: Participants were non-diabetic (mean age and SD: 48.8 +/- 11.2 y) M women (n=221) enrolled in a church-based, cluster randomized trial testing a standard diabetes prevention program (DPP) and a faith-enhanced DPP with 4-months of follow-up. We assessed the relationships of changes in diet, physical activity, neighborhood disadvantage, individual socioeconomic factors, and other lifestyle variables to changes in AL at 4-months using a multilevel multinomial logistic regression model.
   Results: Average AL decreased (-.13 +/-.99, P=.02) from baseline to 4-months. After adjusting for other variables, a high school education or less (OR:.1, CI:.02-.49) and alcohol use (OR: .31, Ci: .09-.99) contributed to increased AL. Living in a disadvantaged neighborhood was responsible for increased AL, though it was not statistically significant. There were no statistically significant associations between AL and other health behavior changes.
   Conclusions: Lower education levels may dampen the benefits of lifestyle interventions in reducing AL. Although a significant reduction in AL was found after participation in a lifestyle intervention, more research is needed to determine how lifestyle behaviors and socioeconomic factors influence AL in AA women.
C1 [Tan, Marissa] Bassett Med Ctr, One Atwell Rd, Cooperstown, NY 13326 USA.
   [Mamun, Abdullah; Dodgen, Leilani] Univ North Texas, Hlth Sci Ctr, Ft Worth, TX USA.
   [Mamun, Abdullah; Kitzman, Heather] Baylor Scott & White Hlth, Dallas, TX USA.
C3 University of North Texas System; University of North Texas Denton;
   Baylor Health Care System
RP Tan, M (corresponding author), Bassett Med Ctr, One Atwell Rd, Cooperstown, NY 13326 USA.
EM marissa.luan.tan@gmail.com
RI Mamun, Abdullah/ABB-5833-2020
OI Mamun, Abdullah/0000-0002-6746-6097; Dodgen, Leilani/0000-0003-1786-3454
FU National Institutes of Health (NIH) [R25HL125447]; NIH [P20MD006882-2]
FX We thank all the women, churches, staff, and volunteers involved in
   Better Me Within for their hard work and support in this study. Research
   was supported by a National Institutes of Health (NIH) grant R25HL125447
   (to Dr. J.K. Vishwanatha) and NIH grant P20MD006882-2. The content is
   solely the responsibility of the authors and does not necessarily
   represent the official views of the National Institutes of Health.
CR [Anonymous], SOCIAL PSYCHOL HLTH
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NR 32
TC 13
Z9 15
U1 0
U2 14
PU INT SOC HYPERTENSION BLACKS-ISHIB
PI ATLANTA
PA 100 AUBURN AVE NE STE 401, ATLANTA, GA 30303-2527 USA
SN 1049-510X
EI 1945-0826
J9 ETHNIC DIS
JI Ethn. Dis.
PD SPR
PY 2019
VL 29
IS 2
BP 297
EP 308
DI 10.18865/ed.29.2.297
PG 12
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA HU3UP
UT WOS:000465200600009
PM 31057315
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Pietzner, M
   Budde, K
   Homuth, G
   Kastenmüller, G
   Henning, AK
   Artati, A
   Krumsiek, J
   Völzke, H
   Adamski, J
   Lerch, MM
   Kühn, JP
   Nauck, M
   Friedrich, N
AF Pietzner, Maik
   Budde, Kathrin
   Homuth, Georg
   Kastenmueller, Gabi
   Henning, Ann-Kristin
   Artati, Anna
   Krumsiek, Jan
   Voelzke, Henry
   Adamski, Jerzy
   Lerch, Markus M.
   Kuehn, Jens P.
   Nauck, Matthias
   Friedrich, Nele
TI Hepatic Steatosis Is Associated With Adverse Molecular Signatures in
   Subjects Without Diabetes
SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Article
ID NONALCOHOLIC FATTY LIVER; BRANCHED-CHAIN; AMINO-ACID;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; DISEASE; NAFLD; BIOMARKERS;
   PROFILES; FIBROSIS
AB Background and Aims: Exaggerated hepatic triglyceride accumulation (i.e., hepatic steatosis) represents a strong risk factor for type 2 diabetes mellitus and cardiovascular disease. Despite the clear association of hepatic steatosis with impaired insulin signaling, the precise molecular mechanisms involved are still under debate. We combined data from several metabolomics techniques to gain a comprehensive picture of molecular alterations related to the presence of hepatic steatosis in a diabetes-free sample (N = 769) of the population-based Study of Health in Pomerania.
   Methods: Liver fat content (LFC) was assessed using MRI. Metabolome measurements of plasma and urine samples were done by mass spectrometry and nuclear magnetic resonance spectroscopy. Linear regression analyses were used to detect significant associations with either LFC or markers of hepatic damage. Possible mediations through insulin resistance, hypertriglyceridemia, and inflammation were tested. A predictive molecular signature of hepatic steatosis was established using regularized logistic regression.
   Results: The LFC-associated atherogenic lipid profile, tightly connected to shifts in the phospholipid content, and a prediabetic amino acid cluster were mediated by insulin resistance. Molecular surrogates of oxidative stress and multiple associations with urine metabolites (e.g., indicating altered cortisol metabolism or phase II detoxification products) were unaffected in mediation analyses. Incorporation of urine metabolites slightly improved classification of hepatic steatosis.
   Conclusions: Comprehensive metabolic profiling allowed us to reveal molecular patterns accompanying hepatic steatosis independent of the known hallmarks. Novel biomarkers from urine (e.g., cortisol glucuronide) are worthwhile for follow-up in patients suffering from more severe liver impairment compared with our merely healthy population-based sample.
C1 [Pietzner, Maik; Budde, Kathrin; Henning, Ann-Kristin; Nauck, Matthias; Friedrich, Nele] Univ Med Greifswald, Inst Clin Chem & Lab Med, Ferdinand Sauerbruch Str NK, D-17475 Greifswald, Germany.
   [Pietzner, Maik; Budde, Kathrin; Voelzke, Henry; Nauck, Matthias; Friedrich, Nele] German Ctr Cardiovasc Res DZHK, Partner Site Greifswald, D-17475 Greifswald, Germany.
   [Homuth, Georg] Univ Med Greifswald, Interfac Inst Genet & Funct Genom, D-17475 Greifswald, Germany.
   [Homuth, Georg] Ernst Moritz Arndt Univ Greifswald, Interfac Inst Genet & Funct Genom, D-17475 Greifswald, Germany.
   [Kastenmueller, Gabi] Helmholtz Zentrum Munchen, Inst Bioinformat & Syst Biol, Neuherberg, Germany.
   [Artati, Anna; Adamski, Jerzy] Helmholtz Zentrum Munchen, Genome Anal Ctr, Inst Expt Genet, D-85764 Neuherberg, Germany.
   [Krumsiek, Jan] Helmholtz Zentrum Munchen, Inst Computat Biol, D-85764 Neuherberg, Germany.
   [Voelzke, Henry] Univ Med Greifswald, Inst Community Med, D-17475 Greifswald, Germany.
   [Voelzke, Henry; Adamski, Jerzy] German Ctr Diabet Res DZD, Site Greifswald, D-17475 Greifswald, Germany.
   [Adamski, Jerzy] Tech Univ Munich, Lehrstuhl Expt Genet, D-85350 Freising Weihenstephan, Germany.
   [Lerch, Markus M.] Univ Med Greifswald, Dept Med A, D-17475 Greifswald, Germany.
   [Kuehn, Jens P.] Univ Med Greifswald, Inst Diagnost Radiol & Neuroradiol, D-17475 Greifswald, Germany.
   [Kuehn, Jens P.] Carl Gustav Carus Univ, Univ Med, Inst Diagnost Radiol, D-01307 Dresden, Germany.
C3 Universitat Greifswald; Greifswald Medical School; German Centre for
   Cardiovascular Research; Universitat Greifswald; Greifswald Medical
   School; Universitat Greifswald; Helmholtz Association; Helmholtz-Center
   Munich - German Research Center for Environmental Health; Helmholtz
   Association; Helmholtz-Center Munich - German Research Center for
   Environmental Health; Helmholtz Association; Helmholtz-Center Munich -
   German Research Center for Environmental Health; Universitat Greifswald;
   Greifswald Medical School; German Center for Diabetes Research (DZD);
   Technical University of Munich; Universitat Greifswald; Greifswald
   Medical School; Universitat Greifswald; Greifswald Medical School;
   Technische Universitat Dresden; Carl Gustav Carus University Hospital
RP Pietzner, M (corresponding author), Univ Med Greifswald, Inst Clin Chem & Lab Med, Ferdinand Sauerbruch Str NK, D-17475 Greifswald, Germany.
EM maik.pietzner@uni-greifswald.de
RI Krumsiek, Jan/B-3961-2013; Kastenmüller, Gabi/ABF-5987-2020; Lerch,
   Markus M./E-2206-2016
OI Adamski, Jerzy/0000-0001-9259-0199; Kastenmuller,
   Gabi/0000-0002-2368-7322; Pietzner, Maik/0000-0003-3437-9963; Lerch,
   Markus M./0000-0002-9643-8263
FU German Federal Ministry of Education and Research [01ZZ0403, 01ZZ0103,
   01GI0883, Athero-SysMed 03IS2061B]; Ministry for Education, Research and
   Cultural Affairs; Ministry of Social Affairs of the Federal State of
   Mecklenburg-West Pomerania; Federal Ministry of Education and Research;
   Ministry of Cultural Affairs of the Federal State of Mecklenburg-West
   Pomerania [03IS2061A]; German Center Diabetes Research (DZD e.V.)
FX This work was funded by grants from the German Federal Ministry of
   Education and Research [grants 01ZZ0403, 01ZZ0103, and 01GI0883 (to
   H.V.) and Athero-SysMed 03IS2061B], the Ministry for Education, Research
   and Cultural Affairs, and the Ministry of Social Affairs of the Federal
   State of Mecklenburg-West Pomerania. This work is also part of the
   research project Greifswald Approach to Individualized Medicine
   (GANI_MED). The GANI_MED consortium is funded by the Federal Ministry of
   Education and Research and the Ministry of Cultural Affairs of the
   Federal State of Mecklenburg-West Pomerania (03IS2061A). Part of this
   study was supported by a German Center Diabetes Research (DZD e.V.)
   grant (to J.A.).
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NR 57
TC 25
Z9 26
U1 0
U2 13
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0021-972X
EI 1945-7197
J9 J CLIN ENDOCR METAB
JI J. Clin. Endocrinol. Metab.
PD OCT
PY 2018
VL 103
IS 10
BP 3856
EP 3868
DI 10.1210/jc.2018-00999
PG 13
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA GY1BQ
UT WOS:000448258100032
PM 30060179
OA Bronze
DA 2025-06-11
ER

PT J
AU Nephan, G
   Coskun, ZM
   Bolkent, S
AF Nephan, Gulay
   Coskun, Zeynep Mine
   Bolkent, Sema
TI Dipeptidyl peptidase-4 inhibition prevents cell death via extrinsic and
   intrinsic apoptotic pathways in rat pancreas with insulin resistance
SO CELL BIOCHEMISTRY AND FUNCTION
LA English
DT Article
DE apoptosis; fructose; insulin resistance; lipid profiles; saxagliptin
ID METABOLIC SYNDROME; OXIDATIVE STRESS; LIVER STEATOSIS; NUCLEAR ANTIGEN;
   FRUCTOSE; DIET; MODEL; INFLAMMATION; HOMEOSTASIS; DYSFUNCTION
AB The study aims to evaluate the effect of saxagliptin, a specific inhibitor of dipeptidyl peptidase-4 enzymes, on body weight gain, lipid profiles, and cell death through apoptosis in rats with insulin resistance (IR). Male adult Sprague-Dawley rats (n=32) were divided into 4 groups: control (Ctrl), IR, saxagliptin control, and IR treated with saxagliptin(IR+S). Insulin resistance was induced by 10% fructose in the drinking water for 8weeks. Saxagliptin (10mg/kg/day) was administrated by oral gavage for 2weeks. Biochemical parameters were measured spectrophotometrically. Peptides were determined by the streptavidin-biotin-peroxidase method. Although the amount of food and liquid consumed are inversely proportional, the calories received are almost equal between both Ctrl and IR groups, as well as IR and IR+S groups. Increased homeostasis model assessment for insulin resistance, HOMA-, triglycerides, and very low-density lipoprotein in the IR group were comparatively decreased by saxagliptin administration. The area percentage of caspase-3 and apoptotic peptidase activating factor-1 immunopositive cells in the IR+S group decreased compared with the IR group. Similarly, the percentages of caspase-8 and -9 immunopositive cells in the IR group were higher than the IR+S group. It was observed that the percentage of poly (ADP-ribose) polymerase-1 immunopositive cells was increased in the IR+S group compared with the IR group. Thus, saxagliptin may prevent IR-induced apoptotic cell death and regulate impaired homeostasis model assessment for insulin resistance and serum lipid levels.
C1 [Nephan, Gulay; Bolkent, Sema] Istanbul Univ, Fac Cerrahpasa Med, Dept Med Biol, TR-34098 Istanbul, Turkey.
   [Coskun, Zeynep Mine] Istanbul Bilim Univ, Fac Arts & Sci, Dept Mol Biol & Genet, Istanbul, Turkey.
C3 Istanbul University - Cerrahpasa; Istanbul University; Demiroglu Bilim
   University
RP Bolkent, S (corresponding author), Istanbul Univ, Fac Cerrahpasa Med, Dept Med Biol, TR-34098 Istanbul, Turkey.
EM semabolkent@yahoo.com
RI Bolkent, Sema/C-9539-2019; coskun, zeynep/AAV-1778-2021
OI COSKUN YAZICI, Zeynep Mine/0000-0003-4791-6537; Bolkent,
   Sema/0000-0001-8463-5561
FU Scientific Research Projects Coordination Unit of Istanbul University
   [51189]
FX Scientific Research Projects Coordination Unit of Istanbul University,
   Grant/Award Number: Project No. 51189.
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NR 44
TC 7
Z9 7
U1 0
U2 9
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0263-6484
EI 1099-0844
J9 CELL BIOCHEM FUNCT
JI Cell Biochem. Funct.
PD JUN
PY 2018
VL 36
IS 4
BP 212
EP 220
DI 10.1002/cbf.3333
PG 9
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA GI2QO
UT WOS:000434216700005
PM 29748970
DA 2025-06-11
ER

PT J
AU Larsson, SC
   Burgess, S
   Michaëlsson, K
AF Larsson, Susanna C.
   Burgess, Stephen
   Michaelsson, Karl
TI Serum magnesium levels and risk of coronary artery disease: Mendelian
   randomisation study
SO BMC MEDICINE
LA English
DT Article
DE Coronary artery disease; Magnesium; Mendelian randomisation;
   Single-nucleotide polymorphisms
ID IMPROVES ENDOTHELIAL FUNCTION; CONTROLLED-TRIALS; GENETIC-VARIANTS;
   BLOOD-PRESSURE; DOUBLE-BLIND; CARDIOVASCULAR-DISEASE; SECONDARY
   HYPOCALCEMIA; METABOLIC SYNDROME; OXIDATIVE STRESS; METAANALYSIS
AB Background: Observational studies have shown that serum magnesium levels are inversely associated with risk of cardiovascular disease, but whether this association is causal is unknown. We conducted a Mendelian randomisation study to investigate whether serum magnesium levels may be causally associated with coronary artery disease (CAD).
   Methods: This Mendelian randomisation analysis is based on summary-level data from the CARDIoGRAMplusC4D consortium's 1000 Genomes-based genome-wide association meta-analysis of 48 studies with a total of 60,801 CAD cases and 123,504 non-cases. Six single-nucleotide polymorphisms associated with serum magnesium levels at genome-wide significance were used as instrumental variables.
   Results: A genetic predisposition to higher serum magnesium levels was inversely associated with CAD. In conventional Mendelian randomisation analysis, the odds ratio of CAD was 0.88 (95% confidence interval [CI] 0.78 to 0.99; P = 0.03) per 0.1-mmol/L (about 1 standard deviation) increase in genetically predicted serum magnesium levels. Results were consistent in sensitivity analyses using the weighted median and heterogeneity-penalised model averaging methods, with odds ratios of 0.84 (95% CI 0.72 to 0.98; P = 0.03) and 0.83 (95% CI 0.71 to 0.96; P = 0.02), respectively.
   Conclusions: This study based on genetics provides evidence that serum magnesium levels are inversely associated with risk of CAD. Randomised controlled trials elucidating whether magnesium supplementation lowers the risk of CAD, preferably in a setting at higher risk of hypomagnesaemia, are warranted.
C1 [Larsson, Susanna C.] Karolinska Inst, Inst Environm Med, Unit Nutr Epidemiol, S-17177 Stockholm, Sweden.
   [Burgess, Stephen] Univ Cambridge, MRC Biostat Unit, Cambridge, England.
   [Burgess, Stephen] Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England.
   [Michaelsson, Karl] Uppsala Univ, Dept Surg Sci, Uppsala, Sweden.
C3 Karolinska Institutet; MRC Biostatistics Unit; University of Cambridge;
   University of Cambridge; Uppsala University
RP Larsson, SC (corresponding author), Karolinska Inst, Inst Environm Med, Unit Nutr Epidemiol, S-17177 Stockholm, Sweden.
EM susanna.larsson@ki.se
RI Burgess, Stephen/ADB-8602-2022; Michaelsson, Karl/AAM-9094-2021;
   Larsson, Susanna/F-6065-2015
OI Larsson, Susanna/0000-0003-0118-0341; Burgess,
   Stephen/0000-0001-5365-8760; Michaelsson, Karl/0000-0003-2815-1217
FU MRC [MC_UU_00002/7, MR/L003120/1] Funding Source: UKRI; British Heart
   Foundation [RG/13/13/30194] Funding Source: Medline; Medical Research
   Council [MC_UU_00002/7, MR/L003120/1] Funding Source: Medline; Wellcome
   Trust [204623/Z/16/Z] Funding Source: Medline
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NR 47
TC 39
Z9 40
U1 0
U2 10
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1741-7015
J9 BMC MED
JI BMC Med.
PD MAY 17
PY 2018
VL 16
AR 68
DI 10.1186/s12916-018-1065-z
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA GH2MW
UT WOS:000433237000001
PM 29769070
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Thorwald, M
   Rodriguez, R
   Lee, A
   Martinez, B
   Peti-Peterdi, J
   Nakano, D
   Nishiyama, A
   Ortiz, RM
AF Thorwald, Max
   Rodriguez, Ruben
   Lee, Andrew
   Martinez, Bridget
   Peti-Peterdi, Janos
   Nakano, Daisuke
   Nishiyama, Akira
   Ortiz, Rudy M.
TI Angiotensin receptor blockade improves cardiac mitochondrial activity in
   response to an acute glucose load in obese insulin resistant rats
SO REDOX BIOLOGY
LA English
DT Article
DE Angiotensin II; Mitochondria; Cardiac; Antioxidant enzymes; TCA cycle
ID MEDIATED OXIDATIVE STRESS; REACTIVE OXYGEN; ACTIVATION; PROTEIN; NRF2;
   TRANSLOCATION; HYPERGLYCEMIA; HYPERTENSION; FIBROBLASTS; P47PHOX
AB Hyperglycemia increases the risk of oxidant overproduction in the heart through activation of a multitude of pathways. Oxidation of mitochondrial enzymes may impair their function resulting in accumulation of intermediates and reverse electron transfer, contributing to mitochondrial dysfunction. Furthermore, the renin-angiotensin system (RAS) becomes inappropriately activated during metabolic syndrome, increasing oxidant production. To combat excess oxidant production, the transcription factor, nuclear factor erythriod-2- related factor 2 (Nrf2), induces expression of many antioxidant genes. We hypothesized that angiotensin II receptor type 1 (AT1) blockade improves mitochondrial function in response to an acute glucose load via upregulation of Nrf2. To address this hypothesis, an oral glucose challenge was performed in three groups prior to dissection (n = 5-8 animals/group/time point) of adult male rats: 1) Long Evans Tokushima Otsuka (LETO; lean strain-control), 2) insulin resistant, obese Otsuka Long Evans Tokushima Fatty (OLETF), and 3) OLETF + angiotensin receptor blocker (ARB; 10 mg olmesartan/kg/d x 6 weeks). Hearts were collected at TO, T60, and T120 minutes post glucose infusion. ARB increased Nrf2 binding 32% compared to OLETF at T60. Total superoxide dismutase (SOD) and catalase (CAT) activities were increased 45% and 66% respectively in ARB treated animals compared to OLETF. Mitochondrial enzyme activities of aconitase, complex I, and complex II increased by 135%, 33% and 66%, respectively in ARB compared to OLETF. These data demonstrate the protective effects of AT1 blockade on mitochondrial function during the manifestation of insulin resistance suggesting that the inappropriate activation of AT1 during insulin resistance may impair Nrf2 translocation and subsequent antioxidant activities and mitochondrial function.
C1 [Thorwald, Max; Rodriguez, Ruben; Lee, Andrew; Martinez, Bridget; Ortiz, Rudy M.] Univ Calif Merced, Sch Nat Sci, Merced, CA 95343 USA.
   [Peti-Peterdi, Janos] Univ Southern Calif, Keck Sch Med, Dept Physiol & Biophys, Los Angeles, CA USA.
   [Nakano, Daisuke; Nishiyama, Akira] Kagawa Univ, Med Sch, Dept Pharmacol, Takamatsu, Kagawa, Japan.
C3 University of California System; University of California Merced;
   University of Southern California; Kagawa University
RP Thorwald, M (corresponding author), Univ Calif Merced, Dept Mol & Cellular Biol, 5200 N Lake Rd, Merced, CA 95343 USA.
EM mthorwald@ucmerced.edu
RI NAKANO, DAISUKE/JWP-5663-2024
OI Nishiyama, Akira/0000-0001-5971-820X; Rodriguez,
   Ruben/0009-0006-5222-7145; Rodriguez, Ruben/0000-0001-8174-2556;
   Thorwald, Max/0000-0003-0095-5344
FU NIH [NCMHD9T37MD001480, NHLBIK02HL103787, NHLBIR01HL091767]
FX M. Thorwald, R. Rodriguez, A.Lee, and B. Martinez were supported by NIH
   NCMHD9T37MD001480. R.M. Ortiz was partially supported by NIH
   NHLBIK02HL103787. Research was partially funded by NIH NHLBIR01HL091767.
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NR 36
TC 20
Z9 25
U1 0
U2 17
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 2213-2317
J9 REDOX BIOL
JI Redox Biol.
PD APR
PY 2018
VL 14
BP 371
EP 378
DI 10.1016/j.redox.2017.10.005
PG 8
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA FS5CM
UT WOS:000419811100036
PM 29049981
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Wang, NN
   Dallas, K
   Li, S
   Baker, L
   Eisenberg, ML
AF Wang, N. N.
   Dallas, K.
   Li, S.
   Baker, L.
   Eisenberg, M. L.
TI The association between varicocoeles and vascular disease: an analysis
   of US claims data
SO ANDROLOGY
LA English
DT Article
DE cardiac disease; infertility; metabolic disease; varicocoele;
   varicocele; vascular disease
ID CARDIOVASCULAR-DISEASE; SERUM TESTOSTERONE; ENDOGENOUS TESTOSTERONE;
   VARICOCELE MANAGEMENT; METABOLIC SYNDROME; MALE-INFERTILITY; INCREASED
   RISK; MEN; MORTALITY; PATHOPHYSIOLOGY
AB Studies have suggested an association between varicocele, hypogonadism, and elevated oxidative stress markers, but no other health risks have been associated with varicoceles. We sought to determine the association between varicocele and incident medical comorbidities. Using the Truven Health MarketScan((R)) claims database from 2001 to 2009, we identified 4459 men with varicoceles, and 100,066 controls based on ICD-9 and CPT codes, with an average follow-up of 3.1 person years. Men with varicoceles were classified as symptomatic or asymptomatic based on co-existing diagnoses. Men with medical comorbidities present before or within 1year of index diagnosis were excluded. Metabolic and cardiovascular outcome variables were identified via ICD-9 codes. A Cox regression analysis was used to assess incident risk of metabolic and cardiovascular disease amongst the different groups. Men with varicoceles had a higher incidence of heart disease compared to men who underwent infertility testing (HR 1.22, 95% CI: 1.03-1.45), and men who underwent vasectomy (HR 1.32, 95% CI 1.13-1.54). The varicoceles group also had a higher risk of diabetes (HR 1.73, 95% CI: 1.37-2.18) and hyperlipidemia (HR 1.15, 95% CI: 1.03-1.28) compared to the vasectomy group. Furthermore, men with symptomatic varicoceles (n=3442) had a higher risk of heart disease, diabetes, and hyperlipidemia following diagnosis, while men with asymptomatic varicoceles (n=1017) did not. Given the prevalence of varicoceles, further research is needed to understand the implications of a varicocele to a man's overall health.
C1 [Wang, N. N.; Dallas, K.] Stanford Hosp & Clin, Dept Urol, 300 Pasteur Dr, Stanford, CA 94305 USA.
   [Li, S.] Stanford Univ, Sch Med, Dept Urol, Palo Alto, CA 94304 USA.
   [Baker, L.] Stanford Univ, Sch Med, Dept Hlth Res & Policy, Stanford, CA 94305 USA.
   [Eisenberg, M. L.] Stanford Univ, Sch Med, Dept Urol Obstet & Gynecol, Stanford, CA 94305 USA.
C3 Stanford University; Stanford Medicine; Stanford University; Stanford
   University; Stanford University
RP Eisenberg, ML (corresponding author), Stanford Hosp & Clin, Dept Urol, 300 Pasteur Dr, Stanford, CA 94305 USA.
EM eisenberg@stanford.edu
OI Wang, Nancy/0000-0003-0796-5625
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NR 30
TC 21
Z9 22
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2047-2919
EI 2047-2927
J9 ANDROLOGY-US
JI Andrology
PD JAN
PY 2018
VL 6
IS 1
BP 99
EP 103
DI 10.1111/andr.12437
PG 5
WC Andrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA FR1AK
UT WOS:000418797400014
PM 29195012
OA Bronze
DA 2025-06-11
ER

PT J
AU Sheldon, RD
   Kanosky, KM
   Wells, KD
   Miles, L
   Perfield, JW
   Xanthakos, S
   Inge, TH
   Rector, RS
AF Sheldon, Ryan D.
   Kanosky, Kayla M.
   Wells, Kevin D.
   Miles, Lili
   Perfield, James W., II
   Xanthakos, Stavra
   Inge, Thomas H.
   Rector, R. Scott
TI Transcriptomic differences in intra-abdominal adipose tissue in
   extremely obese adolescents with different stages of NAFLD
SO PHYSIOLOGICAL GENOMICS
LA English
DT Article
DE RNA-Seq; childhood obesity; transcriptome; inflammation; visceral
   adipose tissue; gene expression
ID FATTY LIVER-DISEASE; RNA SEQUENCING ANALYSIS; INSULIN-RESISTANCE;
   NONALCOHOLIC STEATOHEPATITIS; METABOLIC SYNDROME; GENE-EXPRESSION;
   B-CELL; CHILDREN; ASSOCIATION; LYMPHOTOXIN
AB Mechanisms responsible for progression of nonalcoholic fatty liver disease (NAFLD) to steatohepatitis (NASH) remain poorly defined. To examine the potential contribution of adipose tissue to NAFLD progression, we performed a complete transcriptomic analysis using RNA sequencing (RNA-Seq) on intra-abdominal adipose tissue (IAT) from severely obese adolescents [M-age 16.9 +/- 0.4 yr, body mass index (BMI) z-score 2.7 +/- 0.1] undergoing bariatric surgery and liver biopsy categorized into three groups: no steatosis (normal, n = 8), steatosis only (n = 13), or NASH (n = 10) by liver histology. Age, body weight, and BMI did not differ among groups, but subjects with NASH were more insulin resistant (increased homeostatic model assessment/insulin resistance, P < 0.05 vs. other groups). RNA-Seq revealed 175 up-and 492 downregulated mRNA transcripts (>= +/- 1.5-fold, false discovery rate <0.10) in IAT between NASH vs. Normal, with "mitochondrial dysfunction, P = 4.19E-7" being the top regulated canonical pathway identified by Ingenuity Pathway Analysis; only 19 mRNA transcripts were up-and 148 downregulated when comparing Steatosis vs. Normal, with suppression of "EIF2 signaling, P = 1.79E-27" being the top regulated pathway indicating increased cellular stress. A comparison of IAT between NASH vs. Steatosis found 515 up-and 175 downregulated genes, with "antigen presentation, P = 6.03E-18" being the top regulated canonical pathway and "inflammatory response" the top diseases and disorders function. Unique transcriptomic differences exist in IAT from severely obese adolescents with distinct stages of NAFLD, providing an important resource for identifying potential novel therapeutic targets for childhood NASH.
C1 [Sheldon, Ryan D.; Kanosky, Kayla M.; Rector, R. Scott] Harry S Truman Mem Vet Med Ctr, Res Serv, Columbia, MO USA.
   [Kanosky, Kayla M.; Rector, R. Scott] Univ Missouri, Dept Med, Div Gastroenterol & Hepatol, Columbia, MO USA.
   [Sheldon, Ryan D.; Kanosky, Kayla M.; Perfield, James W., II; Rector, R. Scott] Univ Missouri, Dept Nutr & Exercise Physiol, Columbia, MO USA.
   [Wells, Kevin D.] Univ Missouri, Dept Anim Sci, Columbia, MO USA.
   [Perfield, James W., II] Univ Missouri, Dept Food Sci, Columbia, MO USA.
   [Miles, Lili; Xanthakos, Stavra; Inge, Thomas H.] Cincinnati Childrens Hosp Med Ctr, Cincinnati, OH 45229 USA.
C3 US Department of Veterans Affairs; Veterans Health Administration (VHA);
   Harry S. Truman Memorial Veterans' Hospital; University of Missouri
   System; University of Missouri Columbia; University of Missouri System;
   University of Missouri Columbia; University of Missouri System;
   University of Missouri Columbia; University of Missouri System;
   University of Missouri Columbia; Cincinnati Children's Hospital Medical
   Center
RP Rector, RS (corresponding author), Harry S Truman Mem VA Hosp, CE405 Clin Support Educ Bldg, Columbia, MO 65211 USA.; Rector, RS (corresponding author), Univ Missouri, Dept Internal Med, Div Gastroenterol & Hepatol, CE405 Clin Support Educ Bldg, Columbia, MO 65211 USA.
EM rectors@health.missouri.edu
RI Inge, Thomas/AAG-3372-2020
OI Inge, Thomas/0000-0001-7782-1112; Sheldon, Ryan/0000-0002-1573-9719
FU JR Albert Foundation; University of Missouri Life Sciences Pre-doctoral
   Fellowship; Center for Bariatric Research and Innovation at Cincinnati
   Children's Hospital Medical Center; NIH [K23080888]; National Center for
   Advancing Translational Sciences of the NIH [UL1TR000077];  [VA-CDA2-1
   IK2BX001299]
FX Funding was provided by a grant from the JR Albert Foundation (R. S.
   Rector) and VA-CDA2-1 IK2BX001299 (salary support to R. S. Rector), a
   University of Missouri Life Sciences Pre-doctoral Fellowship (R. D.
   Sheldon), and in part by the Center for Bariatric Research and
   Innovation at Cincinnati Children's Hospital Medical Center (T. H. Inge)
   and NIH Grant K23080888 (S. Xanthakos). The Pediatric Obesity Tissue
   Repository at Cincinnati Children's Hospital Medical Center was also
   supported by the National Center for Advancing Translational Sciences of
   the NIH, under Award Number UL1TR000077. This work was partially
   supported with resources and the use of facilities at the Harry S.
   Truman Memorial Veterans Hospital in Columbia, MO.
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NR 40
TC 9
Z9 10
U1 1
U2 8
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 1094-8341
EI 1531-2267
J9 PHYSIOL GENOMICS
JI Physiol. Genomics
PD DEC
PY 2016
VL 48
IS 12
BP 897
EP 911
DI 10.1152/physiolgenomics.00020.2016
PG 15
WC Cell Biology; Genetics & Heredity; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Genetics & Heredity; Physiology
GA EE5IL
UT WOS:000389639700003
PM 27764764
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Masaki, M
   Mano, T
   Eguchi, A
   Fujiwara, S
   Sugahara, M
   Hirotani, S
   Tsujino, T
   Komamura, K
   Koshiba, M
   Masuyama, T
AF Masaki, Mitsuru
   Mano, Toshiaki
   Eguchi, Akiyo
   Fujiwara, Shohei
   Sugahara, Masataka
   Hirotani, Shinichi
   Tsujino, Takeshi
   Komamura, Kazuo
   Koshiba, Masahiro
   Masuyama, Tohru
TI Long-term effects of L- and N-type calcium channel blocker on uric acid
   levels and left atrial volume in hypertensive patients
SO HEART AND VESSELS
LA English
DT Article
DE Hypertension; Uric acid; L- and N-type calcium channel blocking drugs;
   Diastolic dysfunction
ID CONGESTIVE-HEART-FAILURE; DIASTOLIC DYSFUNCTION; CARDIOVASCULAR-DISEASE;
   ENDOTHELIAL DYSFUNCTION; GREATER-THAN-OR-EQUAL-TO-65 YEARS; METABOLIC
   SYNDROME; OXIDATIVE STRESS; ANGIOTENSIN-II; L/N-TYPE; CILNIDIPINE
AB Left ventricular (LV) diastolic dysfunction is associated with hypertension and hyperuricemia. However, it is not clear whether the L- and N-type calcium channel blocker will improve LV diastolic dysfunction through the reduction of uric acid. The aim of this study was to investigate the effects of anti-hypertensive therapy, the L- and N-type calcium channel blocker, cilnidipine or the L-type calcium channel blocker, amlodipine, on left atrial reverse remodeling and uric acid in hypertensive patients. We studied 62 patients with untreated hypertension, randomly assigned to cilnidipine or amlodipine for 48 weeks. LV diastolic function was assessed with the left atrial volume index (LAVI), mitral early diastolic wave (E), tissue Doppler early diastolic velocity (E') and the ratio (E/E'). Serum uric acid levels were measured before and after treatment. After treatment, systolic and diastolic blood pressures equally dropped in both groups. LAVI, E/E', heart rate and uric acid levels decreased at 48 weeks in the cilnidipine group but not in the amlodipine group. The % change from baseline to 48 weeks in LAVI, E wave, E/E' and uric acid levels were significantly lower in the cilnidipine group than in the amlodipine group. Larger %-drop in uric acid levels were associated with larger %-reduction of LAVI (p < 0.01). L- and N-type calcium channel blocker but not L-type calcium channel blocker may improve LV diastolic function in hypertensive patients, at least partially through the decrease in uric acid levels.
C1 [Masaki, Mitsuru; Mano, Toshiaki; Eguchi, Akiyo; Fujiwara, Shohei; Sugahara, Masataka; Hirotani, Shinichi; Komamura, Kazuo; Masuyama, Tohru] Hyogo Coll Med, Dept Internal Med, Cardiovasc Div, I-1 Mukogawa Cho, Nishinomiya, Hyogo 6638501, Japan.
   [Masaki, Mitsuru; Eguchi, Akiyo; Koshiba, Masahiro] Hyogo Coll Med, Div Clin Lab Med, Nishinomiya, Hyogo, Japan.
   [Masaki, Mitsuru; Eguchi, Akiyo; Koshiba, Masahiro] Hyogo Univ Hlth Sci, Sch Pharm, Dept Pharm, Kobe, Hyogo, Japan.
   [Tsujino, Takeshi] Hyogo Univ Hlth Sci, Sch Pharm, Dept Pharm, Kobe, Hyogo, Japan.
   [Komamura, Kazuo] Takeda Pharmaceut Co Ltd, Osaka Clin, Osaka, Japan.
C3 Hyogo Medical University; Hyogo Medical University; Takeda
   Pharmaceutical Company Ltd
RP Mano, T (corresponding author), Hyogo Coll Med, Dept Internal Med, Cardiovasc Div, I-1 Mukogawa Cho, Nishinomiya, Hyogo 6638501, Japan.
EM mano@hyo-med.ac.jp
OI Sugahara, Masataka/0000-0001-7951-4706
FU Hyogo College of Medicine
FX We thank Ms. M. Tanaka, S. Makihara and C. Misumi for their excellent
   technical assistance in the acquisition of echocardiographic tracings.
   This work was supported by a Grant-in-Aid for Researchers, Hyogo College
   of Medicine, 2014.
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NR 52
TC 8
Z9 11
U1 0
U2 7
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0910-8327
EI 1615-2573
J9 HEART VESSELS
JI Heart Vessels
PD NOV
PY 2016
VL 31
IS 11
BP 1826
EP 1833
DI 10.1007/s00380-016-0796-z
PG 8
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA EB3NF
UT WOS:000387271000012
PM 26825736
DA 2025-06-11
ER

PT J
AU Christensen, JS
   Raaschou-Nielsen, O
   Tjonneland, A
   Overvad, K
   Nordsborg, RB
   Ketzel, M
   Sorensen, TIA
   Sorensen, M
AF Christensen, Jeppe Schultz
   Raaschou-Nielsen, Ole
   Tjonneland, Anne
   Overvad, Kim
   Nordsborg, Rikke B.
   Ketzel, Matthias
   Sorensen, Thorkild I. A.
   Sorensen, Mette
TI Road Traffic and Railway Noise Exposures and Adiposity in Adults: A
   Cross-Sectional Analysis of the Danish Diet, Cancer, and Health Cohort
SO ENVIRONMENTAL HEALTH PERSPECTIVES
LA English
DT Article
ID SHORT-SLEEP DURATION; BODY-MASS INDEX; AIR-POLLUTION; METABOLIC
   SYNDROME; LEPTIN LEVELS; OBESITY; CORTISOL; PREDICTION; WATER; FAT
AB BACKGROUND: Traffic noise has been associated with cardiovascular and metabolic disorders. Potential modes of action are through stress and sleep disturbance, which may lead to endocrine dysregulation and overweight.
   OBJECTIVES: We aimed to investigate the relationship between residential traffic and railway noise and adiposity.
   METHODS: In this cross-sectional study of 57,053 middle-aged people, height, weight, waist circumference, and bioelectrical impedance were measured at enrollment (1993-1997). Body mass index (BMI), body fat mass index (BFMI), and lean body mass index (LBMI) were calculated. Residential exposure to road and railway traffic noise exposure was calculated using the Nordic prediction method. Associations between traffic noise and anthropometric measures at enrollment were analyzed using general linear models and logistic regression adjusted for demographic and lifestyle factors.
   RESULTS: Linear regression models adjusted for age, sex, and socioeconomic factors showed that 5-year mean road traffic noise exposure preceding enrollment was associated with a 0.35-cm wider waist circumference (95% CI: 0.21, 0.50) and a 0.18-point higher BMI (95% CI: 0.12, 0.23) per 10 dB. Small, significant increases were also found for BFMI and LBMI. All associations followed linear exposure-response relationships. Exposure to railway noise was not linearly associated with adiposity measures. However, exposure > 60 dB was associated with a 0.71-cm wider waist circumference (95% CI: 0.23, 1.19) and a 0.19-point higher BMI (95% CI: 0.0072, 0.37) compared with unexposed participants (0-20 dB).
   CONCLUSIONS: The present study finds positive associations between residential exposure to road traffic and railway noise and adiposity.
C1 [Christensen, Jeppe Schultz; Raaschou-Nielsen, Ole; Tjonneland, Anne; Nordsborg, Rikke B.; Sorensen, Mette] Danish Canc Soc, Res Ctr, Diet Genes & Environm, Strandblvd 49, DK-2100 Copenhagen O, Denmark.
   [Raaschou-Nielsen, Ole; Ketzel, Matthias] Aarhus Univ, Dept Environm Sci, Roskilde, Denmark.
   [Overvad, Kim] Aarhus Univ, Dept Publ Hlth, Epidemiol Sect, Aarhus, Denmark.
   [Overvad, Kim] Aalborg Univ Hosp, Dept Cardiol, Aalborg, Denmark.
   [Sorensen, Thorkild I. A.] Novo Nordisk Fdn, Ctr Basic Metab Res, Copenhagen, Denmark.
   [Sorensen, Thorkild I. A.] Fac Hlth & Med Sci, Dept Publ Hlth, Copenhagen, Denmark.
   [Sorensen, Thorkild I. A.] Bispebjerg Hosp, Inst Prevent Med, DK-2400 Copenhagen, Denmark.
   [Sorensen, Thorkild I. A.] Frederiksberg Univ Hosp, Inst Prevent Med, Copenhagen, Denmark.
   [Sorensen, Thorkild I. A.] Univ Bristol, MRC, Integrat Epidemiol Unit, Bristol, Avon, England.
C3 Danish Cancer Society; Aarhus University; Aarhus University; Aalborg
   University; Aalborg University Hospital; Novo Nordisk Foundation;
   University of Copenhagen; Bispebjerg Hospital; Copenhagen University
   Hospital; University of Bristol
RP Christensen, JS (corresponding author), Danish Canc Soc, Res Ctr, Diet Genes & Environm, Strandblvd 49, DK-2100 Copenhagen O, Denmark.
EM jeppe0311@gmail.com
RI Raaschou-Nielsen, Ole/GOK-0338-2022; Tjonneland, Anne/AGU-0320-2022;
   KETZEL, Matthias/K-4246-2015
OI Overvad, Kim/0000-0001-6429-7921; Tjonneland, Anne/0000-0003-4385-2097;
   Raaschou-Nielsen, Ole/0000-0002-1223-0909; KETZEL,
   Matthias/0000-0001-9519-1935; Sorensen, Mette/0000-0002-7302-4789
FU European Research Council, EU 7th Research Framework Programme [281760];
   MRC [MC_UU_12013/1] Funding Source: UKRI
FX The European Research Council, EU 7th Research Framework Programme
   funded this study (grant 281760).
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NR 43
TC 61
Z9 66
U1 0
U2 6
PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE
PI RES TRIANGLE PK
PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233,
   RES TRIANGLE PK, NC 27709-2233 USA
SN 0091-6765
EI 1552-9924
J9 ENVIRON HEALTH PERSP
JI Environ. Health Perspect.
PD MAR
PY 2016
VL 124
IS 3
BP 329
EP 335
DI 10.1289/ehp.1409052
PG 7
WC Environmental Sciences; Public, Environmental & Occupational Health;
   Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health; Toxicology
GA DF6CJ
UT WOS:000371442500019
PM 26241990
OA Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Ghanta, M
   Kozicky, M
   Jim, B
AF Ghanta, Mythili
   Kozicky, Mark
   Jim, Belinda
TI Pathophysiologic and Treatment Strategies for Cardiovascular Disease in
   End-Stage Renal Disease and Kidney Transplantations
SO CARDIOLOGY IN REVIEW
LA English
DT Review
DE cardiovascular disease; end-stage renal disease; kidney transplantation;
   pathophysiology
ID CONVERTING-ENZYME-INHIBITORS; LEFT-VENTRICULAR HYPERTROPHY; VASCULAR
   SMOOTH-MUSCLE; CORONARY-HEART-DISEASE; ALL-CAUSE MORTALITY;
   RISK-FACTORS; BLOOD-PRESSURE; LONG-TERM; PARATHYROID-HORMONE;
   CALCIFICATION PROGRESSION
AB The inextricable link between the heart and the kidneys predestines that significant cardiovascular disease ensues in the face of end-stage renal disease (ESRD). As a point of fact, the leading cause of mortality of patients on dialysis is still from cardiovascular etiologies, albeit differing in particular types of disease from the general population. For example, sudden cardiac death outnumbers coronary artery disease in patients with ESRD, which is the reverse for the general population. In this review, we will focus on the pathophysiology and treatment options of important traditional and nontraditional risk factors for cardiovascular disease in ESRD patients such as hypertension, anemia, vascular calcification, hyperparathyroidism, uremia, and oxidative stress. The evidence of erythropoietin-stimulating agents, phosphate binders, calcimimetics, and dialysis modalities will be presented. We will then discuss how these risk factors may be changed and perhaps exacerbated after renal transplantation. This is largely due to the immunosuppressive agents that are both crucial yet potentially detrimental in the posttransplant state. Calcineurin inhibitors, corticosteroids, and mammalian target of rapamycin inhibitors, the mainstay of transplant immunosuppression, are all known to increase the risks of developing new onset diabetes as well as the metabolic syndrome. Thus, we need to carefully negotiate between patients' cardiovascular profile and their risks of rejection. Finally, we end by considering strategies by which we may minimize cardiovascular disease in the transplant population, as this modality still confers the highest chance of survival in patients with ESRD.
C1 [Ghanta, Mythili] Temple Univ, Dept Med, Sch Med, Div Nephrol, Philadelphia, PA 19140 USA.
   [Kozicky, Mark; Jim, Belinda] Albert Einstein Coll Med, Jacobi Med Ctr, Dept Med, Div Nephrol, Bronx, NY 10467 USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE); Temple
   University; Montefiore Medical Center; Albert Einstein College of
   Medicine; Jacobi Medical Center; Yeshiva University
RP Ghanta, M (corresponding author), Temple Univ, Dept Med, Sch Med, 3440 N Broad St,Suite 100, Philadelphia, PA 19140 USA.
EM mythili.ghanta@tuhs.temple.edu
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   Yu M, 2011, CLIN J AM SOC NEPHRO, V6, P30, DOI 10.2215/CJN.05340610
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NR 138
TC 24
Z9 26
U1 0
U2 9
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1061-5377
EI 1538-4683
J9 CARDIOL REV
JI Cardiol. Rev.
PD MAY-JUN
PY 2015
VL 23
IS 3
BP 109
EP 118
DI 10.1097/CRD.0000000000000044
PG 10
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA CF0AK
UT WOS:000352204700001
PM 25420053
DA 2025-06-11
ER

PT J
AU Lee, K
   Han, J
   Kim, SG
AF Lee, Kyoungho
   Han, Joohee
   Kim, Soo-Geun
TI Increasing risk of diabetes mellitus according to liver function
   alterations in electronic workers
SO JOURNAL OF DIABETES INVESTIGATION
LA English
DT Article
DE Diabetes mellitus; Liver function; Workers
ID GAMMA-GLUTAMYL-TRANSFERASE; METABOLIC SYNDROME; ALANINE
   AMINOTRANSFERASE; INSULIN SENSITIVITY; OXIDATIVE STRESS; ENZYMES;
   PREVALENCE; PREDICTS; OBESITY; ADULTS
AB Aims/IntroductionWe sought to determine the association between change in fasting plasma glucose (FPG) and levels of liver enzymes, such as aspartate transaminase, alanine transaminase and gamma-glutamyltransferase, from health examinations.
   Materials and MethodsA total of 9,393 health screen examinees with no evidence of viral hepatitis, liver diseases, abnormal liver function and diabetes in their past disease history were enrolled in the present study. All the participants underwent three health examinations. Group1 and 4 were stationary groups of those with normal liver enzyme levels in the first and second health examinations (G1), and abnormal liver enzyme levels in the first and second health check-up (G4). Groups2 and 3 were altered groups of those with abnormal liver enzyme levels in the first health examination, which became normal in the second health examination (G2), and from a normal liver enzymes level to an abnormal liver enzymes level (G3).
   ResultsFPG levels were elevated in male participants (P<0.01), and were related to old age (P<0.01), drinking (P<0.01), smoking (P<0.01) and so on. There was a strong relationship between FPG levels in the last health examination and altered liver function enzyme levels from the first health examination to the second check-up. In other words, group4 had the highest level of FPG compared with the other groups (G1<G2<G3).
   ConclusionsAn association was observed between FPG levels and abnormal liver function in manufacturing workers. Abnormal liver function can be closely associated with the development of diabetes.
C1 [Lee, Kyoungho; Han, Joohee] Samsung Elect, Samsung Hlth Res Inst, Yongin, South Korea.
   [Kim, Soo-Geun] Sungkyunkwan Univ Sch Med, Kangbuk Samsung Hosp, Dept Occupat Med, Seoul, South Korea.
C3 Samsung; Sungkyunkwan University (SKKU); Samsung Medical Center
RP Kim, SG (corresponding author), Sungkyunkwan Univ Sch Med, Kangbuk Samsung Hosp, Dept Occupat Med, Seoul, South Korea.
EM soogeun.kim@samsung.com
RI Lee, Kyoung/J-5570-2012
OI Lee, Kyoungho/0000-0003-2353-2547
FU Samsung Electronics
FX This study was financially supported by Samsung Electronics. There is no
   conflict of interest.
CR Chang Y, 2007, CLIN CHEM, V53, P686, DOI 10.1373/clinchem.2006.081257
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NR 22
TC 5
Z9 6
U1 0
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2040-1116
EI 2040-1124
J9 J DIABETES INVEST
JI J. Diabetes Investig.
PD NOV
PY 2014
VL 5
IS 6
BP 671
EP 676
DI 10.1111/jdi.12202
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA AS6EZ
UT WOS:000344358600009
PM 25422767
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Alonso, A
   Misialek, JR
   Amiin, MA
   Hoogeveen, RC
   Chen, LY
   Agarwal, SK
   Loehr, LR
   Soliman, EZ
   Selvin, E
AF Alonso, Alvaro
   Misialek, Jeffrey R.
   Amiin, Mohamed A.
   Hoogeveen, Ron C.
   Chen, Lin Y.
   Agarwal, Sunil K.
   Loehr, Laura R.
   Soliman, Elsayed Z.
   Selvin, Elizabeth
TI Circulating levels of liver enzymes and incidence of atrial
   fibrillation: the Atherosclerosis Risk in Communities cohort
SO HEART
LA English
DT Article
ID METABOLIC SYNDROME; OXIDATIVE STRESS; DISEASE; BIOMARKERS; STROKE;
   HEART; EPIDEMIOLOGY; PREVALENCE; KNOWLEDGE; IMPACT
AB Background Elevated levels of circulating liver enzymes have been associated with increased risk of cardiovascular disease. Their possible association with atrial fibrillation (AF) has received little attention.
   Methods We studied 9333 men and women, aged 53-75 years, free of AF, participating in the Atherosclerosis Risk in Communities Study followed-up from 1996 to 2010. Aspartate aminotransferase (AST), alanine aminotransferase (ALT), and. glutamyl transpeptidase (GGT) were measured in stored plasma samples. Incident AF was ascertained from hospitalisations and death certificates. Associations between liver enzymes and AF incidence were assessed using multivariable Cox proportional hazards models.
   Results During a mean follow-up of 12 years, 1021 incident AF events were identified. Levels of AST, and to a lesser extent ALT, showed a U-shaped association with AF risk, with higher AF risk among individuals in the two extremes of the distribution in minimally adjusted models. The associations were weakened after adjustment for potential confounders. By contrast, GGT, modelled as log base 2, was linearly associated with AF risk after multivariable adjustment: a doubling of GGT levels was associated with a 20% increased risk of AF (95% CI 10% to 30%). Additional adjustment for inflammatory markers did not appreciably affect the results. Associations were not different in men and women, in whites and blacks, among never drinkers of alcohol, and among those without prevalent heart failure.
   Conclusions In this community-based prospective study, higher levels of liver enzymes, mainly GGT, were associated with an increased risk of AF. The mechanisms underlying this association deserve further scrutiny.
C1 [Alonso, Alvaro; Misialek, Jeffrey R.; Amiin, Mohamed A.] Univ Minnesota, Div Epidemiol & Community Hlth, Sch Publ Hlth, Minneapolis, MN 55454 USA.
   [Hoogeveen, Ron C.] Baylor Coll Med, Dept Med, Houston, TX 77030 USA.
   [Hoogeveen, Ron C.] Methodist DeBakey Heart & Vasc Ctr, Houston, TX USA.
   [Chen, Lin Y.] Univ Minnesota, Sch Med, Dept Cardiol, Minneapolis, MN 55455 USA.
   [Agarwal, Sunil K.; Selvin, Elizabeth] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA.
   [Agarwal, Sunil K.] Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21205 USA.
   [Loehr, Laura R.] Univ N Carolina, Dept Epidemiol, Gillings Sch Publ Hlth, Chapel Hill, NC USA.
   [Soliman, Elsayed Z.] Wake Forest Sch Med, Epidemiol Cardiol Res Ctr EPICARE, Winston Salem, NC USA.
C3 University of Minnesota System; University of Minnesota Twin Cities;
   Baylor College of Medicine; Houston Methodist; University of Minnesota
   System; University of Minnesota Twin Cities; Johns Hopkins University;
   Johns Hopkins Bloomberg School of Public Health; Johns Hopkins
   University; University of North Carolina; University of North Carolina
   Chapel Hill; Wake Forest University
RP Alonso, A (corresponding author), Univ Minnesota, Div Epidemiol & Community Hlth, Sch Publ Hlth, 1300 S 2nd St,Suite 300, Minneapolis, MN 55454 USA.
EM alonso@umn.edu
RI Soliman, Elsayed/AAD-7135-2020; Lin, Chih-Cheng/IQT-4912-2023; ALONSO
   GOMEZ, ANGEL/HLG-2476-2023; Selvin, Elizabeth/LTE-9727-2024; Alonso,
   Alvaro/A-4917-2010; Soliman, Elsayed/D-8124-2011
OI Selvin, Elizabeth/0000-0001-6923-7151; Loehr, Laura/0000-0002-9054-1825;
   Chen, Lin/0000-0002-0700-814X; Alonso, Alvaro/0000-0002-2225-8323;
   Hoogeveen, Ron/0000-0003-2399-4653; Soliman, Elsayed/0000-0001-5632-8150
FU National Heart, Lung, and Blood Institute [HHSN268201100005C,
   HHSN268201100006C, HHSN268201100007C, HHSN268201100008C,
   HHSN268201100009C, HHSN268201100010C, HHSN268201100011C,
   HHSN268201100012C]; NHLBI [RC1 HL099452]; American Heart Association
   [09SDG2280087]; American Heart Association (AHA) [09SDG2280087] Funding
   Source: American Heart Association (AHA)
FX The Atherosclerosis Risk in Communities Study is carried out as a
   collaborative study supported by National Heart, Lung, and Blood
   Institute contracts (HHSN268201100005C, HHSN268201100006C,
   HHSN268201100007C, HHSN268201100008C, HHSN268201100009C,
   HHSN268201100010C, HHSN268201100011C, and HHSN268201100012C). This study
   was additionally supported by NHLBI grant RC1 HL099452 and American
   Heart Association grant 09SDG2280087.
CR Alonso A, 2013, J AM HEART ASSOC, V2, DOI 10.1161/JAHA.112.000102
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NR 29
TC 82
Z9 83
U1 1
U2 8
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 1355-6037
EI 1468-201X
J9 HEART
JI Heart
PD OCT
PY 2014
VL 100
IS 19
BP 1511
EP 1516
DI 10.1136/heartjnl-2014-305756
PG 6
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA AP2UT
UT WOS:000341931800010
PM 24924619
OA Green Accepted, Green Submitted
DA 2025-06-11
ER

PT J
AU Lehto, SM
   Elomaa, AP
   Niskanen, L
   Herzig, KH
   Tolmunen, T
   Viinamäki, H
   Koivumaa-Honkanen, H
   Huotari, A
   Honkalampi, K
   Valkonen-Korhonen, M
   Sinikallio, S
   Ruotsalainen, H
   Hintikka, J
AF Lehto, Soili M.
   Elomaa, Antti-Pekka
   Niskanen, Leo
   Herzig, Karl-Heinz
   Tolmunen, Tommi
   Viinamaki, Heimo
   Koivumaa-Honkanen, Heli
   Huotari, Anne
   Honkalampi, Kirsi
   Valkonen-Korhonen, Minna
   Sinikallio, Sanna
   Ruotsalainen, Heli
   Hintikka, Jukka
TI Serum adipokine levels in adults with a history of childhood
   maltreatment
SO PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
LA English
DT Review
DE Adiponectin; Inflammation; Maltreatment; Metabolic disturbance; Resistin
ID TORONTO-ALEXITHYMIA-SCALE; METABOLIC SYNDROME; ADIPOSE-TISSUE;
   RISK-FACTORS; INFLAMMATION; ADIPONECTIN; DISEASE; STRESS; PLASMA; ABUSE
AB Individuals with a history of childhood maltreatment present increased rates of metabolic disturbances, but the underlying mechanisms for such phenomena are poorly understood. This study examined whether the secretion of adipokines, adipocyte-derived inflammation markers closely associated with metabolic disorders, is altered in individuals with a history of childhood maltreatment. The serum levels of inflammatory markers adiponectin and resistin were measured from 147 general population participants who had a history of adverse mental symptoms, and who also reported their experiences of childhood maltreatment. Participants with experiences of childhood maltreatment (n = 30) had lowered levels of serum adiponectin (p = 0.007) and resistin (p = 0.028). The differences in adiponectin levels persisted in multivariate modeling with adjustments for age, gender, and body mass index (OR for each 1 standard deviation decrease in the serum adiponectin level 2.65, 95% CI 1.31-5.35, p = 0.007). Additional adjustments for marital status or a diagnosis of major depressive disorder, or the exclusion of individuals using NSAIDs, oral corticosteroids, or antidepressants did not alter the results. The association between resistin levels and childhood maltreatment did not remain independent in the same models. Our findings suggest that in individuals with previously reported adverse mental symptoms, a history of childhood maltreatment is independently associated with lowered levels of the anti-inflammatory marker adiponectin. This may lead to a lowered anti-inflammatory buffer capacity, which can, in turn, increase the susceptibility to physical and psychological states characterized by pronounced pro-inflammation. (C) 2012 Elsevier Inc. All rights reserved.
C1 [Lehto, Soili M.; Elomaa, Antti-Pekka; Tolmunen, Tommi; Viinamaki, Heimo; Honkalampi, Kirsi; Valkonen-Korhonen, Minna; Hintikka, Jukka] Kuopio Univ Hosp, Dept Psychiat, FI-70211 Kuopio, Finland.
   [Lehto, Soili M.; Elomaa, Antti-Pekka; Niskanen, Leo; Tolmunen, Tommi; Viinamaki, Heimo; Huotari, Anne; Honkalampi, Kirsi; Valkonen-Korhonen, Minna; Ruotsalainen, Heli; Hintikka, Jukka] Univ Eastern Finland, Kuopio, Finland.
   [Niskanen, Leo] Cent Hosp Cent Finland, Jyvaskyla, Finland.
   [Herzig, Karl-Heinz] Univ Oulu, Div Physiol, Inst Biomed, Oulu, Finland.
   [Herzig, Karl-Heinz] Univ Oulu, Bioctr Oulu, Oulu, Finland.
   [Koivumaa-Honkanen, Heli] Univ Oulu, Dept Clin Med, Oulu, Finland.
   [Koivumaa-Honkanen, Heli] Lapland Hosp Dist, Dept Psychiat, Rovaniemi, Finland.
   [Honkalampi, Kirsi] Kuopio Psychiat Ctr, Kuopio, Finland.
   [Sinikallio, Sanna] Kuopio Univ Hosp, Dept Rehabil, SF-70210 Kuopio, Finland.
   [Hintikka, Jukka] Paijat Hame Cent Hosp, Dept Psychiat, Lahti, Finland.
   [Hintikka, Jukka] Univ Tampere, FIN-33101 Tampere, Finland.
C3 Kuopio University Hospital; University of Eastern Finland; University of
   Eastern Finland Hospital; University of Eastern Finland; Central Finland
   Central Hospital; University of Oulu; University of Oulu; University of
   Oulu; University of Eastern Finland; University of Eastern Finland
   Hospital; Kuopio University Hospital; Paijat Hame Central Hospital;
   Tampere University
RP Lehto, SM (corresponding author), Kuopio Univ Hosp, Dept Psychiat, POB 1777, FI-70211 Kuopio, Finland.
EM Soili.Lehto@kuh.fi
RI Koivumaa-Honkanen, Heli/L-1274-2015
OI Lehto, Soili/0000-0003-4324-6679; Ruotsalainen, Heli/0000-0003-4923-5196
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NR 38
TC 21
Z9 24
U1 0
U2 16
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0278-5846
EI 1878-4216
J9 PROG NEURO-PSYCHOPH
JI Prog. Neuro-Psychopharmacol. Biol. Psychiatry
PD JUN 1
PY 2012
VL 37
IS 2
BP 217
EP 221
DI 10.1016/j.pnpbp.2012.01.016
PG 5
WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA 941PX
UT WOS:000303976200002
PM 22336057
DA 2025-06-11
ER

PT J
AU Yessoufou, A
   Wahli, W
AF Yessoufou, Akadiri
   Wahli, Walter
TI Multifaceted roles of peroxisome proliferator-activated receptors
   (PPARs) at the cellular and whole organism levels
SO SWISS MEDICAL WEEKLY
LA English
DT Article
DE PPARs; sexual dimorphism; metabolic syndrome; inflammation; skin wound
   healing
AB Chronic disorders, such as obesity, diabetes, inflammation, non-alcoholic fatty liver disease and atherosclerosis, are related to alterations in lipid and glucose metabolism, in which peroxisome proliferator-activated receptors (PPAR)alpha, PPAR beta/delta and PPAR gamma are involved. These receptors form a subgroup of ligand-activated transcription factors that belong to the nuclear hormone receptor family. This review discusses a selection of novel PPAR functions identified during the last few years. The PPARs regulate processes that are essential for the maintenance of pregnancy and embryonic development. Newly found hepatic functions of PPAR alpha are the mediation of female-specific gene repression and the protection of the liver from oestrogen induced toxicity. PPAR alpha also controls lipid catabolism and is the target of hypolipidaemic drugs, whereas PPAR gamma controls adipocyte differentiation and regulates lipid storage; it is the target for the insulin sensitising thiazolidinediones used to treat type 2 diabetes. Activation of PPAR beta/delta increases lipid catabolism in skeletal muscle, the heart and adipose tissue. In addition, PPAR beta/delta ligands prevent weight gain and suppress macrophage derived inflammation. In fact, therapeutic benefits of PPAR ligands have been confirmed in inflammatory and autoimmune diseases, such as encephalomyelitis and inflammatory bowel disease. Furthermore, PPARs promote skin wound repair. PPAR alpha favours skin healing during the inflammatory phase that follows injury, whilst PPAR beta/delta enhances keratinocyte survival and migration. Due to their collective functions in skin, PPARs represent a major research target for our understanding of many skin diseases. Taken altogether, these functions suggest that PPARs serve as physiological sensors in different stress situations and remain valuable targets for innovative therapies.
C1 [Yessoufou, Akadiri; Wahli, Walter] Univ Lausanne, Natl Res Ctr Frontiers Genet, Ctr Integrat Genom, CH-1015 Lausanne, Switzerland.
C3 University of Lausanne
RP Wahli, W (corresponding author), Univ Lausanne, Natl Res Ctr Frontiers Genet, Ctr Integrat Genom, CH-1015 Lausanne, Switzerland.
EM Walter.Wahli@unil.ch
RI Wahli, Walter/I-3194-2019
FU Swiss National Science Foundation; State of Vaud;
   Bonizzi-Theler-Stiftung; Islamic Development Bank; National Centre of
   Competence in Research Program Frontiers in Genetics
FX The work performed in the authors' laboratory was supported by the Swiss
   National Science Foundation (through individual research grants and
   support from the National Centre of Competence in Research Program
   Frontiers in Genetics to WW), the State of Vaud and the
   Bonizzi-Theler-Stiftung (W.W). AY received a scholarship from the
   Islamic Development Bank.
NR 0
TC 92
Z9 99
U1 0
U2 11
PU E M H SWISS MEDICAL PUBLISHERS LTD
PI MUTTENZ
PA FARNSBURGERSTR 8, CH-4132 MUTTENZ, SWITZERLAND
SN 1424-7860
EI 1424-3997
J9 SWISS MED WKLY
JI Swiss Med. Wkly.
PD OCT 16
PY 2010
VL 140
BP 4
EP +
DI 10.4414/smw.2010.13071
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 679AS
UT WOS:000284132400002
OA Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Mabuchi, T
   Yatsuya, H
   Tamakoshi, K
   Otsuka, R
   Nagasawa, N
   Zhang, HM
   Murata, C
   Wada, K
   Ishikawa, M
   Hori, Y
   Kondo, T
   Hashimoto, S
   Toyoshima, H
AF Mabuchi, T
   Yatsuya, H
   Tamakoshi, K
   Otsuka, R
   Nagasawa, N
   Zhang, HM
   Murata, C
   Wada, K
   Ishikawa, M
   Hori, Y
   Kondo, T
   Hashimoto, S
   Toyoshima, H
TI Association between serum leptin concentration and white blood cell
   count in middle-aged Japanese men and women
SO DIABETES-METABOLISM RESEARCH AND REVIEWS
LA English
DT Article
DE epidemiologic study; hematopoiesis; inflammation; leptin; white blood
   cell
ID BODY-MASS INDEX; METABOLIC SYNDROME; ENDOTHELIAL-CELLS; PROLIFERATION;
   HEMATOPOIESIS; INFLAMMATION; OVERWEIGHT; COMPONENTS; APOPTOSIS; STRESS
AB Background Leptin's hematopoietic or proinflammatory role has been experimentally reported. We investigated whether serum leptin concentrations are associated with white blood cell (WBC) counts in humans.
   Methods Serum leptin concentrations of Japanese civil servants aged 40 to 59 years (1082 men and 200 women) were analyzed in relation to their WBC count. Serum leptin concentrations and WBC counts were measured by radioimmunoassay and automated particle counter respectively, using samples obtained at the time of the participants' annual health checkups.
   Results The geometric mean ( geometric standard deviation) leptin concentrations were 3.25 +/- 1.82 ng/mL and 6.25 +/- 3.99 ng/mL, and the geometric mean WBC counts, 5770 +/- 1269/mm(3) and 5107 +/- 1228/mm(3), in men and women respectively. The WBC count adjusted for age, body mass index (BMI), physical activity, and drinking and smoking habits increased together with the increase in leptin concentration. Multiple linear regression against WBC count by the leptin concentration and those covariates revealed a significant and independent association with serum leptin concentration especially in women (standardized beta = 0.31, p < 0.001), and also in men (standardized beta = 0.17, p < 0.001). BMI was not significantly associated with WBC counts in the multivariate model adjusting for leptin levels in both sexes.
   Conclusions Our results are in line with leptin's hematopoietic or proinflammatory functions. The increased WBC counts often observed in obese people would be mediated by the increased leptin concentration. Ltd. Copyright (C) 2005 John Wiley & Sons, Ltd.
C1 Nagoya Univ, Grad Sch Med, Dept Publ Hlth Hlth Informat Dynam, Field Social Life Sci,Showa Ku, Aichi 4668550, Japan.
C3 Nagoya University
RP Nagoya Univ, Grad Sch Med, Dept Publ Hlth Hlth Informat Dynam, Field Social Life Sci,Showa Ku, 65 Tsurumai Cho, Aichi 4668550, Japan.
EM toyosima@med.nagoya-u.ac.jp
RI Yatsuya, Hiroshi/L-4213-2016
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NR 36
TC 20
Z9 21
U1 0
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1520-7552
EI 1520-7560
J9 DIABETES-METAB RES
JI Diabetes-Metab. Res. Rev.
PD SEP-OCT
PY 2005
VL 21
IS 5
BP 441
EP 447
DI 10.1002/dmrr.540
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 968EL
UT WOS:000232144600004
PM 15724240
DA 2025-06-11
ER

PT J
AU Chao, TH
   Lin, TH
   Cheng, C
   Wu, YW
   Ueng, KC
   Wu, YJ
   Lin, WW
   Leu, HB
   Cheng, HM
   Huang, CC
   Wu, CC
   Lin, CF
   Chang, WT
   Pan, WH
   Chen, PR
   Ting, KH
   Su, CH
   Chu, CS
   Chien, KL
   Yen, HW
   Wang, YC
   Su, TC
   Liu, PY
   Chang, HY
   Chen, PW
   Jimmy, JM
   Juang, JMJ
   Lu, YW
   Lin, PL
   Wang, CP
   Ko, YS
   Chiang, CE
   Hou, CJY
   Wang, TD
   Lin, YH
   Huang, PH
   Chen, WJ
AF Chao, Ting-Hsing
   Lin, Tsung-Hsien
   Cheng, Cheng-, I
   Wu, Yen-Wen
   Ueng, Kwo-Chang
   Wu, Yih-Jer
   Lin, Wei-Wen
   Leu, Hsing-Ban
   Cheng, Hao-Min
   Huang, Chin-Chou
   Wu, Chih-Cheng
   Lin, Chao-Feng
   Chang, Wei-Ting
   Pan, Wen-Han
   Chen, Pey-Rong
   Ting, Ke-Hsin
   Su, Chun-Hung
   Chu, Chih-Sheng
   Chien, Kuo-Liong
   Yen, Hsueh-Wei
   Wang, Yu-Chen
   Su, Ta-Chen
   Liu, Pang-Yen
   Chang, Hsien-Yuan
   Chen, Po-Wei
   Jimmy, Jyh-Ming
   Juang, Jyh-Ming Jimmy
   Lu, Ya-Wen
   Lin, Po-Lin
   Wang, Chao-Ping
   Ko, Yu-Shien
   Chiang, Chern-En
   Hou, Charles Jia-Yin
   Wang, Tzung-Dau
   Lin, Yen-Hung
   Huang, Po-Hsun
   Chen, Wen-Jone
TI 2024 Guidelines of the Taiwan Society of Cardiology on the Primary
   Prevention of Atherosclerotic Cardiovascular Disease--- Part I
SO ACTA CARDIOLOGICA SINICA
LA English
DT Article
DE Atherosclerotic cardiovascular disease; Guidelines; Primary prevention
ID CORONARY-HEART-DISEASE; CHRONIC KIDNEY-DISEASE; ALL-CAUSE MORTALITY;
   C-REACTIVE PROTEIN; ACUTE MYOCARDIAL-INFARCTION; OBSTRUCTIVE
   SLEEP-APNEA; PERIPHERAL ARTERY-DISEASE; INTIMA-MEDIA THICKNESS;
   ANKLE-BRACHIAL INDEX; LONG-TERM RISK
AB Atherosclerotic cardiovascular disease (ASCVD) is one of the leading causes of death worldwide and in Taiwan. It is highly prevalent and has a tremendous impact on global health. Therefore, the Taiwan Society of Cardiology developed these best-evidence preventive guidelines for decision-making in clinical practice involving aspects of primordial prevention including national policies, promotion of health education, primary prevention of clinical risk factors, and management and control of clinical risk factors. These guidelines cover the full spectrum of ASCVD, including chronic coronary syndrome, acute coronary syndrome, cerebrovascular disease, peripheral artery disease, and aortic aneurysm. In order to enhance medical education and health promotion not only for physicians but also for the general public, we propose a slogan (2H2L) for the primary prevention of ASCVD on the basis of the essential role of healthy dietary pattern and lifestyles: "Healthy Diet and Healthy Lifestyles to Help Your Life and Save Your Lives". We also propose an acronym of the modifiable risk factors/enhancers and relevant strategies to facilitate memory: "ABC(2)D(2)EFG-I'M-2 ACE": Adiposity, Blood pressure, Cholesterol and Cigarette smoking, Diabetes mellitus and Dietary pattern, Exercise, Frailty, Gout/hyperuricemia, Inflammation/infection, Metabolic syndrome and Metabolic dysfunction-associated fatty liver disease, Atmosphere (environment), Chronic kidney disease, and Easy life (sleep well and no stress). Some imaging studies can be risk enhancers. Some risk factors/clinical conditions are deemed to be preventable, and healthy dietary pattern, physical activity, and body weight control remain the cornerstone of the preventive strategy.
C1 [Chao, Ting-Hsing; Chang, Hsien-Yuan; Chen, Po-Wei] Natl Cheng Kung Univ, Natl Cheng Kung Univ Hosp, Coll Med, Dept Internal Med, Tainan 704302, Taiwan.
   [Chao, Ting-Hsing; Ueng, Kwo-Chang; Su, Chun-Hung] Chung Shan Med Univ Hosp, Dept Internal Med, Div Cardiol, Taichung, Taiwan.
   [Chao, Ting-Hsing; Ueng, Kwo-Chang; Su, Chun-Hung] Chung Shan Med Univ, Sch Med, Taichung, Taiwan.
   [Lin, Tsung-Hsien; Yen, Hsueh-Wei] Kaohsiung Med Univ Hosp, Dept Internal Med, Div Cardiol, Kaohsiung, Taiwan.
   [Lin, Tsung-Hsien] Kaohsiung Med Univ, Grad Inst Med, Coll Med, Fac Med, Kaohsiung, Taiwan.
   [Cheng, Cheng-, I] Kaohsiung Chang Gung Mem Hosp, Dept Internal Med, Div Cardiol, Kaohsiung, Taiwan.
   [Cheng, Cheng-, I] ChangGung Univ, Coll Med, Sch Med, Taoyuan, Taiwan.
   [Wu, Yen-Wen] Far Eastern Mem Hosp, Cardiovasc Med Ctr, Div Cardiol, New Taipei City, Taiwan.
   [Wu, Yen-Wen; Leu, Hsing-Ban] Natl Yang Ming Chiao Tung Univ, Sch Med, Taipei, Taiwan.
   [Wu, Yen-Wen] Yuan Ze Univ, Grad Inst Med, Taoyuan, Taiwan.
   [Wu, Yih-Jer] MacKay Med Coll, Inst Biomed Sci, Dept Med, New Taipei City, Taiwan.
   [Wu, Yih-Jer; Hou, Charles Jia-Yin] MacKay Mem Hosp, Cardiovasc Ctr, Dept Internal Med, Taipei, Taiwan.
   [Lin, Wei-Wen] Taichung Vet Gen Hosp, Cardiovasc Ctr, Taichung, Taiwan.
   [Leu, Hsing-Ban; Huang, Po-Hsun] Natl Yang Ming Chiao Tung Univ, Cardiovasc Res Ctr, Hsinchu, Taiwan.
   [Leu, Hsing-Ban] Healthcare & Management Ctr, Taipei, Taiwan.
   [Leu, Hsing-Ban; Huang, Chin-Chou; Huang, Po-Hsun] Taipei Vet Gen Hosp, Dept Med, Div Cardiol, Taipei, Taiwan.
   [Cheng, Hao-Min] Natl Yang Ming Chiao Tung Univ, Coll Med, PhD Program Interdisciplinary Med PIM, Hsinchu, Taiwan.
   [Cheng, Hao-Min] Taipei Vet Gen Hosp, Div Fac Dev, Ctr Evidence Based Med, Taipei, Taiwan.
   [Cheng, Hao-Min] Inst Publ Hlth, Hsinchu, Taiwan.
   [Cheng, Hao-Min] Natl Yang Ming Chiao Tung Univ, Inst Hlth & Welf Policy, Coll Med, Hsinchu, Taiwan.
   [Huang, Chin-Chou] Natl Yang Ming Chiao Tung Univ, Inst Pharmacol, Taipei, Taiwan.
   [Wu, Chih-Cheng] Natl Taiwan Univ Hosp, Ctr Qual Management, Hsinchu Branch, Hsinchu, Taiwan.
   [Wu, Chih-Cheng] Natl Taiwan Univ, Coll Med, Taipei, Taiwan.
   [Wu, Chih-Cheng] Natl Tsing Hua Univ, Inst Biomed Engn, Hsinchu, Taiwan.
   [Wu, Chih-Cheng] Natl Hlth Res Inst, Inst Cellular & Syst Med, Zhunan, Taiwan.
   [Lin, Chao-Feng] MacKay Med Coll, Dept Med, New Taipei City, Taiwan.
   [Lin, Chao-Feng] MacKay Mem Hosp, Dept Cardiol, Taipei, Taiwan.
   [Chang, Wei-Ting] Natl Sun Yat Sen Univ, Coll Med, Sch Med, Doctoral Program Clin & Expt Med, Kaohsiung, Taiwan.
   [Chang, Wei-Ting] Natl Sun Yat Sen Univ, Ctr Excellence Metab Associated Fatty Liver Dis, Kaohsiung, Taiwan.
   [Chang, Wei-Ting] Chi Mei Med Ctr, Dept Internal Med, Div Cardiol, Tainan, Taiwan.
   [Pan, Wen-Han] Acad Sinica, Inst Biomed Sci, Taipei, Taiwan.
   [Pan, Wen-Han] Natl Hlth Res Inst, Inst Populat Hlth Sci, Miaoli, Taiwan.
   [Pan, Wen-Han] Natl Taiwan Univ, Inst Biochem & Biotechnol, Taipei, Taiwan.
   [Chen, Pey-Rong] Natl Taiwan Univ Hosp, Dept Dietet, Taipei, Taiwan.
   [Ting, Ke-Hsin] Yunlin Christian Hosp, Dept Internal Med, Div Cardiol, Yunlin, Taiwan.
   [Chu, Chih-Sheng] Kaohsiung Med Univ, Kaohsiung Municipal Ta Tung Hosp, Dept Internal Med, Div Cardiol, Kaohsiung, Taiwan.
   [Chien, Kuo-Liong] Natl Taiwan Univ, Inst Epidemiol & Prevent Med, Coll Publ Hlth, Taipei, Taiwan.
   [Chien, Kuo-Liong] Natl Taiwan Univ Hosp, Dept Internal Med, Taipei, Taiwan.
   [Chien, Kuo-Liong] Natl Taiwan Univ, Coll Med, Taipei, Taiwan.
   [Chien, Kuo-Liong] Natl Taiwan Univ, Populat Hlth Res Ctr, Taipei, Taiwan.
   [Wang, Yu-Chen] Asia Univ Hosp, Div Cardiol, Taichung, Taiwan.
   [Wang, Yu-Chen] Asia Univ, Dept Med Lab Sci & Biotechnol, Taichung, Taiwan.
   [Wang, Yu-Chen] China Med Univ, Coll Med & Hosp, Div Cardiol, Taichung, Taiwan.
   [Su, Ta-Chen] Natl Taiwan Univ Hosp, Cardiovasc Ctr, Dept Internal Med, Taipei, Taiwan.
   [Su, Ta-Chen] Natl Taiwan Univ, Coll Med, Dept Environm & Occupat Med, Taipei, Taiwan.
   [Liu, Pang-Yen] Triserv Gen Hosp, Natl Def Med Ctr, Dept Internal Med, Div Cardiol, Taipei, Taiwan.
   [Juang, Jyh-Ming Jimmy] Natl Taiwan Univ, Coll Med, Heart Failure Ctr, Taipei, Taiwan.
   [Juang, Jyh-Ming Jimmy] Natl Taiwan Univ, Coll Med, Dept Internal Med, Div Cardiol, Taipei, Taiwan.
   [Juang, Jyh-Ming Jimmy] Natl Taiwan Univ Hosp, Taipei, Taiwan.
   [Lu, Ya-Wen] Natl Yang Ming Chiao Tung Univ, Inst Clin Med, Taipei, Taiwan.
   [Lin, Po-Lin] Hsinchu MacKay Mem Hosp, Dept Internal Med, Div Cardiol, Hsinchu, Taiwan.
   [Wang, Chao-Ping] E Da Hosp, Div Cardiol, Kaohsiung, Taiwan.
   [Wang, Chao-Ping] I Shou Univ, Coll Med, Sch Med Int Students, Kaohsiung, Taiwan.
   [Ko, Yu-Shien] Chang Gung Mem Hosp, Cardiovasc Div, Taoyuan, Taiwan.
   [Ko, Yu-Shien] Chang Gung Univ, Coll Med, Taoyuan, Taiwan.
   [Chiang, Chern-En] Taipei Vet Gen Hosp, Gen Clin Res Ctr, Taipei, Taiwan.
   [Chiang, Chern-En] Taipei Vet Gen Hosp, Div Cardiol, Taipei, Taiwan.
   [Chiang, Chern-En] Natl Yang Ming Chiao Tung Univ, Taipei, Taiwan.
   [Wang, Tzung-Dau] Natl Taiwan Univ Hosp, Cardiovasc Ctr, Taipei, Taiwan.
   [Wang, Tzung-Dau] Natl Taiwan Univ Hosp, Div Hosp Med, Taipei, Taiwan.
   [Wang, Tzung-Dau] Natl Taiwan Univ Hosp, Dept Internal Med, Div Cardiol, Taipei, Taiwan.
   [Wang, Tzung-Dau] Natl Taiwan Univ, Coll Med, Taipei, Taiwan.
   [Lin, Yen-Hung] Natl Taiwan Univ Hosp, Dept Internal Med, Div Cardiol, Taipei, Taiwan.
   [Lin, Yen-Hung] Natl Taiwan Univ, Coll Med, Taipei, Taiwan.
   [Chen, Wen-Jone] Min Sheng Gen Hosp, Dept Internal Med, Taoyuan, Taiwan.
   [Chen, Wen-Jone] Natl Taiwan Univ, Coll Med, Dept Internal Med, Taipei, Taiwan.
C3 National Cheng Kung University; National Cheng Kung University Hospital;
   Chung Shan Medical University; Chung Shan Medical University Hospital;
   Chung Shan Medical University; Kaohsiung Medical University; Kaohsiung
   Medical University Hospital; Kaohsiung Medical University; Chang Gung
   Memorial Hospital; Far Eastern Memorial Hospital; National Yang Ming
   Chiao Tung University; Yuan Ze University; Mackay Medical College;
   Mackay Memorial Hospital; Taichung Veterans General Hospital; National
   Yang Ming Chiao Tung University; Taipei Veterans General Hospital;
   National Yang Ming Chiao Tung University; Taipei Veterans General
   Hospital; National Yang Ming Chiao Tung University; National Yang Ming
   Chiao Tung University; National Taiwan University; National Taiwan
   University Hospital; National Taiwan University; National Tsing Hua
   University; National Health Research Institutes - Taiwan; Mackay Medical
   College; Mackay Memorial Hospital; National Sun Yat Sen University;
   National Sun Yat Sen University; Chi Mei Hospital; Academia Sinica -
   Taiwan; National Health Research Institutes - Taiwan; National Taiwan
   University; National Taiwan University; National Taiwan University
   Hospital; Kaohsiung Medical University; Kaohsiung Municipal Ta-Tung
   Hospital; National Taiwan University; National Taiwan University;
   National Taiwan University Hospital; National Taiwan University;
   National Taiwan University; Asia University Taiwan; China Medical
   University Taiwan; National Taiwan University; National Taiwan
   University Hospital; National Taiwan University; Tri-Service General
   Hospital; National Defense Medical Center; National Taiwan University;
   National Taiwan University; National Taiwan University; National Taiwan
   University Hospital; National Yang Ming Chiao Tung University; Mackay
   Memorial Hospital; E-Da Hospital; I Shou University; Chang Gung Memorial
   Hospital; Chang Gung University; Taipei Veterans General Hospital;
   Taipei Veterans General Hospital; National Yang Ming Chiao Tung
   University; National Taiwan University; National Taiwan University
   Hospital; National Taiwan University; National Taiwan University
   Hospital; National Taiwan University; National Taiwan University
   Hospital; National Taiwan University; National Taiwan University;
   National Taiwan University Hospital; National Taiwan University;
   National Taiwan University
RP Chao, TH (corresponding author), Natl Cheng Kung Univ, Natl Cheng Kung Univ Hosp, Coll Med, Dept Internal Med, Tainan 704302, Taiwan.; Chao, TH (corresponding author), Chung Shan Med Univ Hosp, Dept Internal Med, Div Cardiol, Taichung, Taiwan.; Chao, TH (corresponding author), Chung Shan Med Univ, Sch Med, Taichung, Taiwan.
EM chaoth@mail.ncku.edu.tw
RI Chu, Pao-Hsien/G-3685-2010; Cheng, Hao-min/L-2576-2018; Huang,
   Po-Hsun/A-2713-2015; Chen, Pei-Lung/A-3520-2010; Lin,
   Tsung-Hsien/D-4514-2009; Chen, Chien-Hung/AFU-7949-2022; Lin,
   Yen-Hung/F-7111-2013; Wang, Tzung-Dau/AFT-4816-2022; Chen,
   Fu-Cheng/ABD-1759-2020; Chang, Chun-Hung/AAT-1641-2021; Lin,
   Po-Lin/AAQ-8144-2020
OI WU, YEN-WEN/0000-0003-1520-1166
FU Na-tional Science and Technology Council [NSC 111-2314-B-006 -019 -MY3]
FX This work is supported by the grant from the Na-tional Science and
   Technology Council under the grant number: NSC 111-2314-B-006 -019 -MY3.
   We thank for the assistance from Dr. Kuan-Ting Chen in preparation of
   this manuscript.
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NR 570
TC 3
Z9 3
U1 4
U2 7
PU TAIWAN SOC CARDIOLOGY
PI TAIPEI
PA 13F-1, NO. 11, MIN-CHUAN WEST ROAD, TAIPEI, 104, TAIWAN
SN 1011-6842
J9 ACTA CARDIOL SIN
JI Acta Cardiol. Sin.
PD SEP
PY 2024
VL 40
IS 5
BP 479
EP 543
DI 10.6515/ACS.202409_40(5).20240724A
PG 65
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA G7Q9C
UT WOS:001318548400002
PM 39308649
DA 2025-06-11
ER

PT J
AU Souza, NMPD
   Rosa, DKAD
   de Moraes, C
   Caeran, M
   Hoffmann, MB
   Aita, EP
   Prochnow, L
   Motta, ALAD
   Corbellini, VA
   Rieger, A
AF Souza, Nikolas Mateus Pereira de
   Rosa, Dhuli Kimberli Abeg da
   de Moraes, Caroline
   Caeran, Mariana
   Hoffmann, Mairim Bordin
   Aita, Eduardo Pozzobon
   Prochnow, Laura
   Motta, Anna Lya Assmann da
   Corbellini, Valeriano Antonio
   Rieger, Alexandre
TI Structural characterization of DNA amplicons by ATR-FTIR spectroscopy as
   a guide for screening metainflammatory disorders in blood plasma
SO SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
LA English
DT Article
DE ATR-FTIR spectroscopy; Metainflammation; Variable selection; Cell -free
   DNA
AB Attenuated total reflectance (ATR) Fourier transform infrared (FTIR) spectroscopy is a promising rapid, reagentfree, and low-cost technique considered for clinical translation. It allows to characterize biofluids proteome, lipidome, and metabolome at once. Metainflammatory disorders share a constellation of chronic systemic inflammation, oxidative stress, aberrant adipogenesis, and hypoxia, that significantly increased cardiovascular and cancer risk. As a result, these patients have elevated concentration of cfDNA in the bloodstream. Considering this, DNA amplicons were analyzed by ATR-FTIR at 3 concentrations with 1:100 dilution: (IU/mL): 718, 7.18, and 0.0718. The generated IR spectrum was used as a guide for variable selection. The main peaks in the biofingerprint (1800-900 cm -1) give important information about the base, base -sugar, phosphate, and sugarphosphate transitions of DNA. To validate our method of selecting variables in blood plasma, 38 control subjects and 12 with metabolic syndrome were used. Using the wavenumbers of the peaks in the biofingerprint of the DNA amplicons, was generated a discriminant analysis model with Mahalanobis distance in blood plasma, and 100 % discrimination accuracy was obtained. In addition, the interval 1475-1188 cm -1 showed the greatest sensitivity to variation in the concentration of DNA amplicons, so curve fitting with Gaussian funcion was performed, obtaining adjusted -R2 of 0.993. PCA with Mahalanobis distance in the interval 1475-1188 cm -1 obtained an accuracy of 96 % and PLS-DA modeling in the interval 1475-1088 cm -1 obtained AUC = 0.991 with sensitivity of 95 % and specificity of 100 %. Therefore, ATR-FTIR spectroscopy with variable selection guided by DNA IR peaks is a promising and efficient method to be applied in metainflammatory disorders.
C1 [Souza, Nikolas Mateus Pereira de; de Moraes, Caroline; Caeran, Mariana; Hoffmann, Mairim Bordin; Aita, Eduardo Pozzobon; Prochnow, Laura; Motta, Anna Lya Assmann da; Rieger, Alexandre] Univ Santa Cruz Do Sul UNISC, Dept Hlth Sci, Postgrad Program Hlth Promot, Santa Cruz Do Sul, RS, Brazil.
   [Rosa, Dhuli Kimberli Abeg da] State Univ Rio Grande do Sul, Bioproc Engn & Biotechnol, Santa Cruz Do Sul, RS, Brazil.
   [Corbellini, Valeriano Antonio] Univ Santa Cruz Do Sul UNISC, Dept Hlth Sci, Postgrad Program Hlth Promot, Santa Cruz Do Sul, RS, Brazil.
   [Corbellini, Valeriano Antonio; Rieger, Alexandre] Univ Santa Cruz Do Sul UNISC, Dept Hlth Sci, Postgrad Program Hlth Promot, Santa Cruz Do Sul, RS, Brazil.
   [Corbellini, Valeriano Antonio; Rieger, Alexandre] Univ Santa Cruz Do Sul UNISC, Dept Hlth Sci, Postgrad Program Hlth Promot, Santa Cruz Do Sul, RS, Brazil.
   [Rieger, Alexandre] Univ Santa Cruz Do Sul UNISC, Dept Life Sci, Lab Entomol, Santa Cruz Do Sul, Brazil.
C3 Universidade de Santa Cruz do Sul; Universidade Estadual do Rio Grande
   do Sul (UERGS); Universidade de Santa Cruz do Sul; Universidade de Santa
   Cruz do Sul; Universidade de Santa Cruz do Sul; Universidade de Santa
   Cruz do Sul
RP Rieger, A (corresponding author), Univ Santa Cruz Do Sul UNISC, Dept Life Sci, Lab Entomol, Santa Cruz Do Sul, Brazil.
EM nikolas1@mx2.unisc.br; dhuli-rosa@uergs.edu.br; cmoraes8989@gmail.com;
   maricaeran@gmail.com; bordinmairim@gmail.com;
   eduardopozzobonaita@gmail.com; lauraprochnow@mx2.unisc.br;
   annalya@mx2.unisc.br; valer@unisc.br; rieger@unisc.br
RI , Nikolas Mateus Pereira de Souza/IXN-5583-2023; Rieger,
   Alexandre/C-1809-2015
OI , Nikolas Mateus Pereira de Souza/0000-0002-4301-5187; , Dhuli Kimberli
   Abeg da Rosa/0009-0009-6228-732X; Caeran, Mariana/0009-0007-2816-0152;
   Rieger, Alexandre/0000-0001-7523-7211; Prochnow,
   Laura/0009-0000-5633-1640
FU Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq,
   modality PIBITI/CNPq)
FX The authors acknowledge the Conselho Nacional de Desenvolvimento
   Cientifico e Tecnologico (CNPq, modality PIBITI/CNPq) for scholarship
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NR 40
TC 3
Z9 3
U1 0
U2 3
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 1386-1425
EI 1873-3557
J9 SPECTROCHIM ACTA A
JI Spectroc. Acta Pt. A-Molec. Biomolec. Spectr.
PD APR 5
PY 2024
VL 310
AR 123897
DI 10.1016/j.saa.2024.123897
EA JAN 2024
PG 10
WC Spectroscopy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Spectroscopy
GA JB8V2
UT WOS:001170795100001
PM 38266599
DA 2025-06-11
ER

PT J
AU Al-Chalabi, S
   Syed, AA
   Kalra, PA
   Sinha, S
AF Al-Chalabi, Saif
   Syed, Akheel A.
   Kalra, Philip A.
   Sinha, Smeeta
TI Mechanistic Links between Central Obesity and Cardiorenal Metabolic
   Diseases
SO CARDIORENAL MEDICINE
LA English
DT Review
DE Obesity; Chronic kidney disease; Metabolic syndrome; Heart failure;
   Cardiorenal syndrome
ID SYMPATHETIC-NERVOUS-SYSTEM; GLP-1 RECEPTOR AGONISTS; INSULIN-RESISTANCE;
   LIFE-STYLE; HYPERTENSION; RISK; IMPACT; MANAGEMENT; MORTALITY; PARADOX
AB Background: There is a marked increase in the global prevalence of obesity over the last decades with an estimated 1.9 billion adults living with overweight or obesity. This is associated with a sharp rise in prevalence of cardiorenal metabolic diseases such as type 2 diabetes mellitus, chronic kidney disease, and heart failure. With recent evidence of the efficacy of sodium glucose cotransporter-2 inhibitors and glucagon-like peptide-1 receptor agonists on cardiorenal protection and weight reduction, it is reasonable to investigate common causative pathways for cardiorenal metabolic diseases. Summary: Central obesity is a common condition with 41.5% prevalence worldwide. It is associated with adverse outcomes even in people with a normal body mass index. Central obesity develops when the personal fat threshold for expansion in the subcutaneous adipose tissue exceeds a certain level. Multiple factors such as age, gender, genetics, and hormones may play a role in determining personal susceptibility to central obesity. Cardiorenal metabolic diseases usually cluster in certain populations - commonly in people with central obesity - and cause a substantial burden on health services and increase the risk of all-cause mortality. In this review, we investigate the pathophysiological pathways between central obesity and cardiorenal metabolic diseases. These pathways include activation of the renin-angiotensin-aldosterone system and the sympathetic nervous system, inflammation and oxidative stress, haemodynamic impairment, insulin resistance, and endothelial dysfunction. Key Message: Central obesity has a pivotal role in the development of cardiorenal metabolic diseases and should be targeted with population-based approaches, such as dietary and lifestyle interventions, as well as the development of pharmacotherapy to reduce the burden of cardiorenal metabolic diseases.
C1 [Al-Chalabi, Saif; Kalra, Philip A.; Sinha, Smeeta] Northern Care Alliance NHS Fdn Trust, Salford Royal Hosp, Dept Renal Med, Salford, England.
   [Al-Chalabi, Saif; Syed, Akheel A.; Kalra, Philip A.; Sinha, Smeeta] Univ Manchester, Fac Biol Med & Hlth, Manchester, England.
   [Syed, Akheel A.] Northern Care Alliance NHS Fdn Trust, Salford Royal Hosp, Dept Diabet Endocrinol & Obes Med, Salford, England.
C3 Salford Royal NHS Foundation Trust; Salford Royal Hospital; University
   of Manchester; Salford Royal NHS Foundation Trust; Salford Royal
   Hospital
RP Sinha, S (corresponding author), Northern Care Alliance NHS Fdn Trust, Salford Royal Hosp, Dept Renal Med, Salford, England.; Sinha, S (corresponding author), Univ Manchester, Fac Biol Med & Hlth, Manchester, England.
EM smeeta.sinha@nca.nhs.uk
RI ; Syed, Akheel/G-3138-2011
OI Al-Chalabi, Saif/0000-0003-1669-8514; Syed, Akheel/0000-0001-8696-7121
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NR 83
TC 9
Z9 10
U1 1
U2 6
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1664-3828
EI 1664-5502
J9 CARDIORENAL MED
JI CardioRenal Med.
PY 2024
VL 14
IS 1
BP 12
EP 22
DI 10.1159/000535772
PG 11
WC Cardiac & Cardiovascular Systems; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Urology & Nephrology
GA NV1X2
UT WOS:001203151000001
PM 38171343
OA gold
DA 2025-06-11
ER

PT J
AU Brown, EB
   Zhang, JW
   Lloyd, E
   Lanzon, E
   Botero, V
   Tomchik, S
   Keene, AC
AF Brown, Elizabeth B.
   Zhang, Jiwei
   Lloyd, Evan
   Lanzon, Elizabeth
   Botero, Valentina
   Tomchik, Seth
   Keene, Alex C.
TI Neurofibromin 1 mediates sleep depth in Drosophila
SO PLOS GENETICS
LA English
DT Article
ID METABOLIC-RATE; DIETARY RESTRICTION; OXIDATIVE STRESS; LIFE-SPAN;
   BARRIER DYSFUNCTION; TYPE-1; DEPRIVATION; PLASTICITY; CHILDREN; MEMORY
AB Neural regulation of sleep and metabolic homeostasis are critical in many aspects of human health. Despite extensive epidemiological evidence linking sleep dysregulation with obesity, diabetes, and metabolic syndrome, little is known about the neural and molecular basis for the integration of sleep and metabolic function. The RAS GTPase-activating gene Neurofibromin (Nf1) has been implicated in the regulation of sleep and metabolic rate, raising the possibility that it serves to integrate these processes, but the effects on sleep consolidation and physiology remain poorly understood. A key hallmark of sleep depth in mammals and flies is a reduction in metabolic rate during sleep. Here, we examine multiple measures of sleep quality to determine the effects of Nf1 on sleep-dependent changes in arousal threshold and metabolic rate. Flies lacking Nf1 fail to suppress metabolic rate during sleep, raising the possibility that loss of Nf1 prevents flies from integrating sleep and metabolic state. Sleep of Nf1 mutant flies is fragmented with a reduced arousal threshold in Nf1 mutants, suggesting Nf1 flies fail to enter deep sleep. The effects of Nf1 on sleep can be localized to a subset of neurons expressing the GABAA receptor Rdl. Sleep loss has been associated with changes in gut homeostasis in flies and mammals. Selective knockdown of Nf1 in Rdl-expressing neurons within the nervous system increases gut permeability and reactive oxygen species (ROS) in the gut, raising the possibility that loss of sleep quality contributes to gut dysregulation. Together, these findings suggest Nf1 acts in GABA-sensitive neurons to modulate sleep depth in Drosophila.
C1 [Brown, Elizabeth B.; Zhang, Jiwei; Lloyd, Evan; Keene, Alex C.] Texas A&M Univ, Dept Biol, College Stn, TX 77843 USA.
   [Brown, Elizabeth B.] Florida State Univ, Dept Biol Sci, Tallahassee, FL USA.
   [Lanzon, Elizabeth] Florida Atlantic Univ, Jupiter Life Sci Initiat, Jupiter, FL USA.
   [Botero, Valentina; Tomchik, Seth] Univ Iowa, Carver Coll Med, Dept Neurosci & Pharmacol, Iowa City, IA USA.
C3 Texas A&M University System; Texas A&M University College Station; State
   University System of Florida; Florida State University; State University
   System of Florida; Florida Atlantic University; University of Iowa
RP Keene, AC (corresponding author), Texas A&M Univ, Dept Biol, College Stn, TX 77843 USA.
EM akeene@bio.tamu.edu
OI Botero, Valentina/0000-0002-9744-3929; Tomchik, Seth/0000-0001-5686-0833
FU National Institutes of Health [R21NS124198, R01DC017390, R01 NS126361,
   R01 NS114403, R01 NS097237, K99AG071833]; National Institute on Aging
   [K99AG071833] Funding Source: NIH RePORTER; National Institute on
   Deafness and Other Communication Disorders [R01DC017390] Funding Source:
   NIH RePORTER
FX This work was supported by the National Institutes of Health grant
   numbers: R21NS124198 to A.C.K and S.T., R01DC017390 to A.C.K., R01
   NS126361 to S.T., R01 NS114403 to S.T., R01 NS097237 to S.T., and
   K99AG071833 to E.B.B. The funders had no role in study design, data
   collection and analysis, decision to publish, or preparation of the
   manuscript. All authored received salary support from the National
   Institute of Health.
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NR 115
TC 4
Z9 4
U1 1
U2 3
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1553-7404
J9 PLOS GENET
JI PLoS Genet.
PD DEC
PY 2023
VL 19
IS 12
AR e1011049
DI 10.1371/journal.pgen.1011049
PG 28
WC Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Genetics & Heredity
GA CK5U6
UT WOS:001125167700003
PM 38091360
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Liang, Y
   Zhang, R
   Biswas, S
   Bu, QF
   Xu, ZB
   Qiao, L
   Zhou, Y
   Tang, JQ
   Zhou, JR
   Zhou, HM
   Lu, L
AF Liang, Yuan
   Zhang, Rui
   Biswas, Siddhartha
   Bu, Qingfa
   Xu, Zibo
   Qiao, Lei
   Zhou, Yan
   Tang, Jiaqi
   Zhou, Jinren
   Zhou, Haoming
   Lu, Ling
TI Integrated single-cell transcriptomics reveals the hypoxia-induced
   inflammation-cancer transformation in NASH-derived hepatocellular
   carcinoma
SO CELL PROLIFERATION
LA English
DT Article
ID FATTY LIVER-DISEASE; GENE-EXPRESSION; LANDSCAPE; HOMEOSTASIS; MOUSE;
   NAFLD
AB Non-alcoholic fatty liver disease (NAFLD) has emerged as the primary risk factor for hepatocellular carcinoma (HCC), owing to improved vaccination rates of Hepatitis B and the increasing prevalence of metabolic syndrome related to obesity. Although the importance of innate and adaptive immune cells has been emphasized, the malignant transformation of hepatocytes and their intricate cellular network with the immune system remain unclear. The study incorporated four single-cell transcriptomic datasets of liver tissues covering healthy and NAFLD-related disease status. To identify the subsets and functions of hepatocytes and macrophages, we employed differential composition analysis, functional enrichment analysis, pseudotime analysis, and scenic analysis. Furthermore, an experimental mouse model for the transformation of nonalcoholic steatohepatitis into hepatocellular carcinoma was established for validation purposes. We defined CYP7A1(+) hepatocytes enriched in precancerous lesions as 'Transitional Cells' in the progression from NAFLD to HCC. CYP7A1(+) hepatocytes upregulated genes associated with stress response, inflammation and cancer-associated pathways and downregulated the normal hepatocyte signature. We observed that hypoxia activation accompanied the entire process of inflammation-cancer transformation. Hepatocyte-derived HIF1A was gradually activated during the progression of NAFLD disease to adapt to the hypoxic microenvironment and hepatocytes under hypoxic environment led to changes in the metabolism, proliferation and angiogenesis, promoting the occurrence of tumours. Meanwhile, hypoxia induced the polarization of RACK1(+) macrophages that enriched in the liver tissues of NASH towards immunosuppressed TREM2(+) macrophages. Moreover, immunosuppressive TREM2(+) macrophages were recruited by tumour cells through the CCL15-CCR1 axis to enhance immunosuppressive microenvironment and promote NAFLD-related HCC progression. The study provides a deep understanding of the development mechanism of NAFLD-related HCC and offers theoretical support and experimental basis for biological targets, drug research, and clinical application.
C1 [Liang, Yuan; Zhang, Rui; Biswas, Siddhartha; Bu, Qingfa; Xu, Zibo; Qiao, Lei; Zhou, Jinren; Zhou, Haoming; Lu, Ling] Nanjing Med Univ, Hepatobiliary Ctr, Res Unit Liver Transplantat & Transplant Immunol, Affiliated Hosp 1,Chinese Acad Med Sci, Nanjing, Jiangsu, Peoples R China.
   [Liang, Yuan] Southeast Univ, Sch Biol Sci & Med Engn, Nanjing, Peoples R China.
   [Qiao, Lei; Tang, Jiaqi] Nanjing Med Univ, Dept Bioinformat, Nanjing, Peoples R China.
   [Zhou, Yan] Nanjing Univ, Nanjing Drum Tower Hosp, Dept Pancreat Surg, Affiliated Hosp ,Med Sch, Nanjing, Peoples R China.
   [Lu, Ling] Xuzhou Med Univ, Affiliated Hosp, Xuzhou, Peoples R China.
C3 Nanjing Medical University; Chinese Academy of Medical Sciences - Peking
   Union Medical College; Southeast University - China; Nanjing Medical
   University; Nanjing University; Xuzhou Medical University
RP Lu, L (corresponding author), Nanjing Med Univ, Hepatobiliary Ctr, Res Unit Liver Transplantat & Transplant Immunol, Affiliated Hosp 1,Chinese Acad Med Sci, Nanjing, Jiangsu, Peoples R China.
EM lvling@njmu.edu.cn
RI Bu, Qingfa/JRZ-1335-2023; zhou, haoming/HMV-1715-2023
OI Zhou, Yan/0000-0002-4973-7543
FU the State Key Laboratory of Reproductive Medicine
FX <STRONG> </STRONG>the National Natural Science Foundation of China,
   Grant/Award Number: 81971495; 2022 Jiangsu Graduate Research and
   Innovation Program, Grant/Award Numbers: KYCX22_1842, SJCX22_0668; the
   CAMS Innovation Fund for Medical Sciences, Grant/Award Number:
   2019-I2M-5-035; the State Key Laboratory of Reproductive Medicine,
   Grant/Award Number: SKLRM-K202001r No Statement Availabler No Statement
   Availabler No Statement Available
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NR 69
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Z9 10
U1 6
U2 13
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0960-7722
EI 1365-2184
J9 CELL PROLIFERAT
JI Cell Prolif.
PD APR
PY 2024
VL 57
IS 4
DI 10.1111/cpr.13576
EA NOV 2023
PG 18
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA MO5E2
UT WOS:001117585800001
PM 37994257
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Mansouri, S
   Salari, AA
   Abedi, A
   Mohammadi, P
   Amani, M
AF Mansouri, Soraya
   Salari, Ali-Akbar
   Abedi, Ali
   Mohammadi, Parham
   Amani, Mohammad
TI Melatonin treatment improves cognitive deficits by altering inflammatory
   and neurotrophic factors in the hippocampus of obese mice
SO PHYSIOLOGY & BEHAVIOR
LA English
DT Article
DE Physical activity; Metabolic syndrome; Memory; Cognition; Hippocampus;
   Mice
ID HIGH-FAT DIET; DEPRESSIVE-LIKE BEHAVIOR; MEMORY IMPAIRMENT; RECOGNITION
   MEMORY; RAT MODEL; STRESS; BDNF; NEUROINFLAMMATION; DYSFUNCTION;
   EXPRESSION
AB Overweight and obesity are associated with an increased risk of developing dementia and cognitive deficits. Neuroinflammation is one of the most important mechanisms behind cognitive impairment in obese patients. In recent years, the neuroendocrine hormone melatonin has been suggested to have therapeutic effects for memory decline in several neuropsychiatric and neurological conditions. However, the effects of melatonin on cognitive function under obesity conditions still need to be clarified. The purpose of this study was to determine whether melatonin treatment can improve cognitive impairment in obese mice. To this end, male C57BL6 mice were treated with a high-fat diet (HFD) for 20 weeks to induce obesity. The animal received melatonin for 8 weeks. Cognitive functions were evaluated using the Y maze, object recognition test, and the Morris water maze. We measured inflammatory cytokines including tumor necrosis factor (TNF)-alpha, interferon (IFN)-gamma, interleukin (IL) -17A, and brain-derived neurotrophic factor (BDNF) in the hippocampus of obese mice. Our results show that HFD-induced obesity significantly impaired working, spatial and recognition memory by increasing IFN-gamma and IL -17A and decreasing BDNF levels in the hippocampus of mice. On the other hand, melatonin treatment effectively improved all cognitive impairments and reduced TNF-alpha, IFN-gamma, and IL-17A and elevated BDNF levels in the hippocampus of obese mice. Taken together, this study suggests that melatonin treatment could have a beneficial role in the treatment of cognitive impairment in obesity.
C1 [Mansouri, Soraya; Abedi, Ali; Mohammadi, Parham; Amani, Mohammad] Ardabil Univ Med Sci, Sch Med, Dept Physiol, Ardebil 5618953141, Iran.
   [Salari, Ali-Akbar] Salari Inst Cognit & Behav Disorders SICBD, Karaj, Alborz, Iran.
   [Salari, Ali-Akbar] Radboud Univ Nijmegen, Donders Inst Brain Cognit & Behav, Dept Cognit Neurosci, Med Ctr, Nijmegen, Netherlands.
C3 Ardabil University of Medical Sciences; Radboud University Nijmegen
RP Amani, M (corresponding author), Ardabil Univ Med Sci, Sch Med, Dept Physiol, Ardebil 5618953141, Iran.
EM m.amani@outlook.com
RI Abedi, Ali/R-7384-2017; Salari, Ali-Akbar/I-7843-2013; Amani,
   Mohammad/R-6957-2017
OI Salari, Ali-Akbar/0000-0002-4970-0337; Amani,
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NR 95
TC 13
Z9 13
U1 0
U2 16
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0031-9384
EI 1873-507X
J9 PHYSIOL BEHAV
JI Physiol. Behav.
PD OCT 1
PY 2022
VL 254
AR 113919
DI 10.1016/j.physbeh.2022.113919
EA JUL 2022
PG 7
WC Psychology, Biological; Behavioral Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Behavioral Sciences
GA 3Y2BQ
UT WOS:000843533900002
PM 35858673
DA 2025-06-11
ER

PT J
AU Reja, D
   Makar, M
   Visaria, A
   Karanfilian, B
   Rustgi, V
AF Reja, Debashis
   Makar, Michael
   Visaria, Aayush
   Karanfilian, Briette
   Rustgi, Vinod
TI Blood lead level is associated with advanced liver fibrosis in patients
   with non-alcoholic fatty liver disease: A nationwide survey (NHANES
   2011-2016)
SO ANNALS OF HEPATOLOGY
LA English
DT Article
DE Nonalcoholic fatty liver disease; Lead; Fibrosis
ID INDUCED OXIDATIVE STRESS; SOCIOECONOMIC-STATUS; ALCOHOL-CONSUMPTION;
   HEPATOTOXICITY; AGE; CHILDHOOD; EXPOSURE; SMOKING
AB Introduction and objectives: Non-Alcoholic Fatty Liver Disease (NAFLD) is linked to obesity and metabolic syndrome, but increasing evidence also implicates environmental toxins. In this study, we aim to show that in elevated blood Lead levels in NAFLD patients result in worsening liver fibrosis.
   Materials and methods: 30,172 patients from NHANES 2011-2016 met inclusion criteria. 2499 patients ages 20-74 were identified with NAFLD as determined by the Fatty Liver Index score, and 425 with advanced liver fibrosis were identified using the NAFLD Fibrosis Score. Simple linear regression, Student's T-test, and Rao-Scott Chi-Square test was used for continuous and categorical variables. Multivariate regression analysis was used to adjust for confounders to determine odds of Advanced Fibrosis.
   Results: Increased serum Lead level was independently associated with increased risk of Advanced Fibrosis (OR 5.93, 95% CI 2.88-12.24) in the highest Lead quartile (Q4). In subgroup analysis stratified by BMI, a significant association between advanced liver fibrosis and blood Lead levels was consistently present, Q4 (OR 5.78, 95% CI 0.97-33.63) and Q4 (OR 6.04, 95% CI 2.92-12.48) in BMI <30 and >30, respectively. Increased Lead exposure was also evident in patients who were older, less educated, male, and drank alcohol and smoked tobacco.
   Conclusions: Our findings show that advanced liver fibrosis is up to six times more likely in NAFLD patients with increased Lead exposure. (C) 2020 Fundacion Clinica Medica Sur, A.C. Published by Elsevier Espana, S.L.U.
C1 [Reja, Debashis; Makar, Michael; Karanfilian, Briette] Rutgers Robert Wood Johnson Med Sch, Dept Internal Med, 1 Robert Wood Johnson Pl, New Brunswick, NJ 08901 USA.
   [Visaria, Aayush] Rutgers New Jersey Med Sch, 185 South Orange Ave, Newark, NJ USA.
   [Rustgi, Vinod] Rutgers Robert Wood Johnson Sch Med, Ctr Liver Dis & Masses, 1 Robert Wood Johnson Pl, New Brunswick, NJ 08901 USA.
C3 Rutgers University System; Rutgers University New Brunswick; Rutgers
   University Biomedical & Health Sciences; Rutgers University System;
   Rutgers University New Brunswick; Rutgers University Biomedical & Health
   Sciences; Rutgers University System; Rutgers University New Brunswick;
   Rutgers University Biomedical & Health Sciences
RP Reja, D (corresponding author), Rutgers Robert Wood Johnson Med Sch, Dept Internal Med, 1 Robert Wood Johnson Pl, New Brunswick, NJ 08901 USA.
EM Dr845@rwjms.rutgers.edu
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NR 26
TC 25
Z9 27
U1 1
U2 16
PU ELSEVIER ESPANA
PI MADRID
PA CALLE DE ZURBANO, 76-4TH FLR LEFT, MADRID, 28010, SPAIN
SN 1665-2681
J9 ANN HEPATOL
JI Ann. Hepatol.
PD JUL-AUG
PY 2020
VL 19
IS 4
BP 404
EP 410
DI 10.1016/j.aohep.2020.03.006
PG 7
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA NJ2CN
UT WOS:000565853200011
PM 32376236
OA gold
DA 2025-06-11
ER

PT J
AU Shipelin, V
   Sidorova, Y
   Mazo, V
   Zorin, S
   Petrov, N
   Kiseleva, T
   Kochetkova, A
AF Shipelin, Vladimir
   Sidorova, Yulia
   Mazo, Vladimir
   Zorin, Sergey
   Petrov, Nikita
   Kiseleva, Tatiana
   Kochetkova, Alla
TI Protective Potential and Antidiabetic Activity of Bilberry Leaves in
   Zucker Rats
SO CURRENT NUTRITION & FOOD SCIENCE
LA English
DT Article
DE Bilberry leaves; diabetes mellitus; functional food products; histology;
   hypoglycemic effect; hypolipidemic effect; pathomorphology; Zucker rats
ID FATTY LIVER-DISEASE; INFLAMMATORY STATUS; METABOLIC SYNDROME; OXIDATIVE
   STRESS; INJURY; STEATOSIS; IMPROVES; MODELS; RISK; DIET
AB Objective: The protective potential of Bilberry Leaves Extract (BLE) was studied in the experiment on male diabetic obese Zucker rats (ZDF) rats (Crl:ZUC-Lepr(fa)) with liver metabolism disorders and hyperglycemia.
   Methods: Animals were fed with or without BLE (2 g/kg b.w.) orally via a gastric tube for 28 days. At the end of the experiment, biochemical and morphological indices were studied.
   Results: Daily intake of BLE in obese ZDF rats produced a marked and sustained decrease in body weight without an increase in food intake in comparison with untreated obese rats. By the end of the study, fasting blood glucose for rats receiving BLE was significantly lower than in control group (P<0.05). The serum levels of aspartate aminotransferase and alkaline phosphatase, biomarkers of liver damage, were significantly (P<0.05) lower in BLE group compared to the obese control animals. There were also reductions (P<0.05) in total cholesterol and high-density lipoproteins levels associated with BLE treatments. BLE administration to obese rats significantly reduced serum urea levels compared to the untreated obese rats. The results also showed a decrease in liver/body weight ratio which is undoubtedly a positive effect together with a general reduction in body weight in BLE treated animals.
   Conclusion: These data suggest that BLE inhibited the development of hyperglycemia, improved lipid metabolism, and influenced positively on some integral indices and a histological picture in the target organs of obese ZDF rats.
C1 [Shipelin, Vladimir; Sidorova, Yulia; Mazo, Vladimir; Zorin, Sergey; Petrov, Nikita; Kiseleva, Tatiana; Kochetkova, Alla] Fed Res Ctr Nutr Biotechnol & Food Safety, Fed State Budgetary Sci Inst, Lab Alimentary Correct Metabolome Disorders, Moscow, Russia.
C3 Federal Research Center of Nutrition, Biotechnology & Food Safety
RP Shipelin, V (corresponding author), Fed Res Ctr Nutr Biotechnol & Food Safety, Fed State Budgetary Sci Inst, Lab Alimentary Correct Metabolome Disorders, Moscow, Russia.
EM v.shipelin@yandex.ru
RI Shipelin, Vladimir/N-4692-2016; Sidorova, Yulia/S-2803-2016; Mazo,
   Vladimir/LMO-6113-2024; Zorin, Sergey/ABF-4744-2021; Kochetkova,
   Alla/I-3900-2017
OI Kochetkova, Alla/0000-0001-9821-192X
FU Russian Scientific Foundation [14-36-00041]; Russian Science Foundation
   [14-36-00041] Funding Source: Russian Science Foundation
FX The study was funded by a grant from the Russian Scientific Foundation
   no. 14-36-00041 "Specialized foods with modified carbohydrate profiles
   for personalized diet therapy of type 2 diabetes".
CR Baynes J, 2009, OXID MED CELL LONGEV, V2, P328, DOI 10.4161/oxim.2.5.9831
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NR 29
TC 0
Z9 1
U1 1
U2 5
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1573-4013
EI 2212-3881
J9 CURR NUTR FOOD SCI
JI Curr. Nutr. Food Sci.
PY 2020
VL 16
IS 2
BP 228
EP 236
DI 10.2174/1573401315666181206123717
PG 9
WC Nutrition & Dietetics
WE Emerging Sources Citation Index (ESCI)
SC Nutrition & Dietetics
GA KN4LI
UT WOS:000514809800014
DA 2025-06-11
ER

PT J
AU Rouhani, MH
   Najafabadi, MM
   Esmaillzadeh, A
   Feizi, A
   Azadbakht, L
AF Rouhani, Mohammad Hossein
   Najafabadi, Mojgan Mortazavi
   Esmaillzadeh, Ahmad
   Feizi, Awat
   Azadbakht, Leila
TI Direct association between high fat dietary pattern and risk of being in
   the higher stages of chronic kidney disease
SO INTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCH
LA English
DT Article
DE Chronic Kidney Disease; Dietary Pattern; Blood Urea Nitrogen; Serum
   Creatinine
ID CORONARY-HEART-DISEASE; SYSTEMIC INFLAMMATION; METABOLIC SYNDROME;
   ENDOTHELIAL DYSFUNCTION; MEDITERRANEAN DIET; INSULIN-RESISTANCE;
   OXIDATIVE STRESS; VEGETABLE-OILS; BLOOD-PRESSURE; OLIVE OIL
AB Background: Although there are some reports on the association of dietary patterns and chronic kidney disease (CKD), no data exists regarding the relation between dietary pattern and CKD from developing countries. Objective: To examine the association between major dietary patterns, renal function and progression of CKD. Methods: Two hundred twenty one subjects with diagnosed CKD were selected for this cross-sectional study. Dietary intake of patients was assessed by a validated food frequency questionnaire. Major dietary patterns were extracted by factor analysis. Renal function was measured by blood urea nitrogen (BUN) and serum creatinine (Cr) level as well as estimated glomerular filtration rate (eGFR). Results: Three major dietary patterns were identified: high fruits and vegetables, high simple carbohydrate and sugar and high fat. Subjects in the second quartile of high fat dietary pattern score had lower Cr and higher eGFR in compared with the first quartile after adjusting for covariates (P = 0.02 for both). After adjusting for confounders (age, physical activity, socioeconomic status, height, weight, systolic and diastolic blood pressure and energy intake), patients in the top quartile of high fat dietary pattern score were found to be at greater risk of being in the higher stages (stage 3 vs. stages 4 and 5) of CKD (odds ratio: 3.09; 95% CI: 1.23, 7.76; P for trend = 0.02). Conclusion: We observed that a high fat dietary pattern was directly associated with progression of CKD.
C1 [Rouhani, Mohammad Hossein; Azadbakht, Leila] Isfahan Univ Med Sci, Food Secur Res Ctr, Sch Nutr & Food Sci, Esfahan, Iran.
   [Rouhani, Mohammad Hossein; Azadbakht, Leila] Isfahan Univ Med Sci, Dept Community Nutr, Sch Nutr & Food Sci, Esfahan, Iran.
   [Najafabadi, Mojgan Mortazavi] Isfahan Kidney Dis Res Ctr, Dept Nephrol, Esfahan, Iran.
   [Esmaillzadeh, Ahmad; Azadbakht, Leila] Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Community Nutr, POB 14155-6117, Tehran, Iran.
   [Feizi, Awat] Isfahan Univ Med Sci, Fac Epidemiol & Biostat, Esfahan, Iran.
   [Azadbakht, Leila] Univ Tehran Med Sci, Diabet Res Ctr, Endocrinol & Metab Clin Sci Inst, Tehran, Iran.
C3 Isfahan University of Medical Sciences; Isfahan University of Medical
   Sciences; Tehran University of Medical Sciences; Isfahan University of
   Medical Sciences; Tehran University of Medical Sciences
RP Azadbakht, L (corresponding author), Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Community Nutr, POB 14155-6117, Tehran, Iran.
EM l-azadbakht@tums.ac.ir
RI Azadbakht, Leila/N-2801-2018; Rouhani, Mohammad/H-6937-2019; MOrtazavi,
   Mojgan/C-6553-2018; Esmaillzadeh, Ahmad/N-5704-2014; Feizi,
   Awat/W-3409-2017
OI Feizi, Awat/0000-0002-1930-0340
FU Research Council of the Food Security Research Center, Isfahan
   University of Medical Sciences, Isfahan, Iran
FX L.A, A.E, A.F and M.M.N designed the study. M.H.R and M.M.N collected
   data. M.H.R, L.A and A.F performed statistical analysis. M.H.R and L.A
   wrote manuscript. The authors appreciate the financial support provided
   by the Research Council of the Food Security Research Center, Isfahan
   University of Medical Sciences, Isfahan, Iran.
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TC 5
Z9 5
U1 2
U2 12
PU VERLAG HANS HUBER
PI BERN 9
PA LANGGASS-STRASSE 76, CH-3000 BERN 9, SWITZERLAND
SN 0300-9831
EI 1664-2821
J9 INT J VITAM NUTR RES
JI Int. J. Vitam. Nutr. Res.
PD NOV
PY 2019
VL 89
IS 5-6
BP 261
EP 270
DI 10.1024/0300-9831/a000260
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA JQ4IQ
UT WOS:000498911300006
PM 30932792
DA 2025-06-11
ER

PT J
AU Barbour, LA
AF Barbour, Linda A.
TI Metabolic Culprits in Obese Pregnancies and Gestational Diabetes
   Mellitus: Big Babies, Big Twists, Big Picture The 2018 Norbert Freinkel
   Award Lecture
SO DIABETES CARE
LA English
DT Article
ID PLACENTAL GROWTH-HORMONE; SEVERE INSULIN-RESISTANCE; FETAL-GROWTH;
   GLUCOSE; WOMEN; FAT; GLYCEMIA; WEIGHT; DIET; HYPERGLYCEMIA
AB Pregnancy has been equated to a "stress test" in which placental hormones and growth factors expose a mother's predisposition toward metabolic disease, unleashing her previously occult insulin resistance (IR), mild beta-cell dysfunction, and glucose and lipid surplus due to the formidable forces of pregnancy-induced IR. Although pregnancy-induced IR is intended to assure adequate nutrition to the fetus and placenta, in mothers with obesity, metabolic syndrome, or those who develop gestational diabetes mellitus, this overnutrition to the fetus carries a lifetime risk for increased metabolic disease. Norbert Freinkel, nearly 40 years ago, coined this excess intrauterine nutrient exposure and subsequent offspring developmental risk "fuel-mediated teratogenesis," not limited to only excess maternal glucose. Our attempts to better elucidate the causes and mechanisms behind this double-edged IR of pregnancy, to metabolically characterize the intrauterine environment that results in changes in newborn body composition and later childhood obesity risk, and to examine potential therapeutic approaches that might target maternal metabolism are the focus of this article. Rapidly advancing technologies in genomics, proteomics, and metabolomics offer us innovative approaches to interrogate these metabolic processes in the mother, her microbiome, the placenta, and her offspring that contribute to a phenotype at risk for future metabolic disease. If we are successful in our efforts, the researcher, endocrinologist, obstetrician, and health care provider fortunate enough to care for pregnant women have the unique opportunity to positively impact health outcomes not only in the short term but in the long run, not just in one life but in two-and possibly, for the next generation.
C1 [Barbour, Linda A.] Univ Colorado, Div Endocrinol, Anschutz Med Campus, Aurora, CO 80045 USA.
   [Barbour, Linda A.] Univ Colorado, Div Metab & Diabet, Anschutz Med Campus, Aurora, CO 80045 USA.
   [Barbour, Linda A.] Univ Colorado, Div Maternal Fetal Med, Anschutz Med Campus, Aurora, CO 80045 USA.
C3 University of Colorado System; University of Colorado Anschutz Medical
   Campus; University of Colorado System; University of Colorado Anschutz
   Medical Campus; University of Colorado System; University of Colorado
   Anschutz Medical Campus
RP Barbour, LA (corresponding author), Univ Colorado, Div Endocrinol, Anschutz Med Campus, Aurora, CO 80045 USA.; Barbour, LA (corresponding author), Univ Colorado, Div Metab & Diabet, Anschutz Med Campus, Aurora, CO 80045 USA.; Barbour, LA (corresponding author), Univ Colorado, Div Maternal Fetal Med, Anschutz Med Campus, Aurora, CO 80045 USA.
EM lynn.barbour@ucdenver.edu
FU NIH [R01DK078645, R01DK101659, R21DK088324]
FX This work was funded by NIH grants R01DK078645, R01DK101659, and
   R21DK088324.
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NR 66
TC 42
Z9 45
U1 0
U2 13
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0149-5992
EI 1935-5548
J9 DIABETES CARE
JI Diabetes Care
PD MAY
PY 2019
VL 42
IS 5
BP 718
EP 726
DI 10.2337/dci18-0048
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA HU4IX
UT WOS:000465238900013
PM 31010942
OA Green Published
DA 2025-06-11
ER

PT J
AU Mohammadi, M
   Ramezani-Jolfaie, N
   Lorzadeh, E
   Khoshbakht, Y
   Salehi-Abargouei, A
AF Mohammadi, Mohammad
   Ramezani-Jolfaie, Nahid
   Lorzadeh, Elnaz
   Khoshbakht, Yadollah
   Salehi-Abargouei, Amin
TI Hesperidin, a major flavonoid in orange juice, might not affect lipid
   profile and blood pressure: A systematic review and meta-analysis of
   randomized controlled clinical trials
SO PHYTOTHERAPY RESEARCH
LA English
DT Review
DE blood pressure; citrus flavonoid; hesperidin; lipid profile;
   meta-analysis; systematic review
ID MESSENGER-RNA LEVELS; CROSS-OVER TRIAL; CITRUS FLAVONOIDS; VEGETABLE
   CONSUMPTION; GLUCOSYL HESPERIDIN; ENDOTHELIAL FUNCTION; CARDIOVASCULAR
   RISK; METABOLIC SYNDROME; OXIDATIVE STRESS; DOUBLE-BLIND
AB Previous studies have led to conflicting results regarding the effect of hesperidin supplementation on cardiometabolic markers. This study aimed to evaluate the efficacy of hesperidin supplementation on lipid profile and blood pressure through a systematic review and meta-analysis of randomized controlled trials (RCTs). PubMed, Web of Science, Scopus, and Google Scholar, as well as the reference lists of the identified relevant RCTs, were searched up to May 2018. Effect sizes were pooled by using the random effects model. Ten RCTs (577 participants) were eligible to be included in the systematic review. The meta-analysis revealed that hesperidin supplementation had no effect on serum total cholesterol (weighted mean difference [WMD] = -1.04 mg/dl; 95% confidence interval [CI]: -5.65, 3.57), low-density lipoprotein cholesterol (WMD = -1.96 mg/dl; 95% CI [-7.56, 3.64]), high-density lipoprotein cholesterol (WMD = 0.16 mg/dl; 95% CI [-1.94, 2.28]), and triglyceride (WMD = 0.69 mg/dl; 95% CI [-5.91, 7.30]), with no significant between-study heterogeneity. Hesperidin supplement also had no effect on systolic (WMD = -0.85 mmHg; 95% CI [-3.07, 1.36]) and diastolic blood pressure (WMD = -0.48 mmHg; 95% CI [-2.39, 1.42]). Hesperidin supplementation might not improve lipid profile and blood pressure. Future well-designed trials are still needed to confirm these results.
C1 [Mohammadi, Mohammad; Ramezani-Jolfaie, Nahid; Lorzadeh, Elnaz; Khoshbakht, Yadollah; Salehi-Abargouei, Amin] Shahid Sadoughi Univ Med Sci, Nutr & Food Secur Res Ctr, Yazd, Iran.
   [Mohammadi, Mohammad; Ramezani-Jolfaie, Nahid; Lorzadeh, Elnaz; Khoshbakht, Yadollah; Salehi-Abargouei, Amin] Shahid Sadoughi Univ Med Sci, Sch Publ Hlth, Dept Nutr, Yazd, Iran.
C3 Shahid Sadoughi University of Medical Sciences; Shahid Sadoughi
   University of Medical Sciences
RP Salehi-Abargouei, A (corresponding author), Shahid Sadoughi Univ Med Sci, Sch Publ Hlth, Dept Nutr, Nutr Sci, Yazd, Iran.
EM abargouei@ssu.ac.ir
RI zarch, mohammad/AAB-2718-2020; Ramezani-Jolfaie, Nahid/AAV-9979-2020;
   Lorzadeh, Elnaz/AAM-1590-2021; Salehi-Abargouei, Amin/C-9039-2011
OI Salehi-Abargouei, Amin/0000-0002-7580-6717
FU Nutrition and Food Security research center, Shahid Sadoughi University
   of Medical Sciences, Yazd, Iran
FX Nutrition and Food Security research center, Shahid Sadoughi University
   of Medical Sciences, Yazd, Iran
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NR 78
TC 41
Z9 42
U1 0
U2 27
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0951-418X
EI 1099-1573
J9 PHYTOTHER RES
JI Phytother. Res.
PD MAR
PY 2019
VL 33
IS 3
BP 534
EP 545
DI 10.1002/ptr.6264
PG 12
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA HO6UH
UT WOS:000461067400005
PM 30632207
DA 2025-06-11
ER

PT J
AU Lin, SP
   Liu, CY
   Yang, CY
AF Lin, Shih-Pi
   Liu, Chieh-Yu
   Yang, Chiu-Yueh
TI Relationship Between Lifestyles That Promote Health and Quality of Life
   in Patients With Chronic Schizophrenia: A Cross-Sectional Study
SO JOURNAL OF NURSING RESEARCH
LA English
DT Article
DE canonical correlation; lifestyles that promote health; quality of life;
   schizophrenia
ID PHYSICAL-ACTIVITY; BIPOLAR DISORDER; METABOLIC SYNDROME; BEHAVIORS;
   COMMUNITY; SYMPTOMS; CHINESE; PROFILE; PEOPLE; IMPACT
AB Background: Over the last few decades, an increasing number of studies have examined quality of life in patients with chronic schizophrenia. However, little research has addressed the relationship between lifestyles that promote health and quality of life issues in these patients.
   Purpose: The aim of this study was to investigate the relationships between lifestyles that promote health and quality of life in patients with chronic schizophrenia.
   Methods: A cross-sectional study design was used. The study was conducted at 10 hospital-based psychiatric rehabilitation units in northern Taiwan. In total, 357 participants completed the World Health Organization Quality of Life-BREF and the Health-Promoting Lifestyle Profile. This study examined the relationships among the six domains of the Health-Promoting Lifestyle Profile and the four domains of the Quality of Life-BREF using canonical correlation analysis. Data collection occurred between April 2013 and April 2014.
   Results: The results of the canonical correlation analysis showed that the Health-Promoting Lifestyle Profile domains of nutrition, health responsibility, self-actualization, interpersonal support, exercise, and stress management were significantly related to the Quality of Life-BREF results, specifically in the physical, psychological, and social relationships and environment domains. Two canonical correlations were identified (the canonical correlation coefficients were .622 and .317), which showed that 38.6% of the variance in lifestyles that promote health and quality of life was shared.
   Conclusions/Implications for Practice: The results of this study may be useful to practitioners who are responsible for lifestyles that promote health and quality of life issues in patients with chronic schizophrenia.
C1 [Lin, Shih-Pi; Yang, Chiu-Yueh] Natl Yang Ming Univ, Dept Nursing, Taipei, Taiwan.
   [Liu, Chieh-Yu] Natl Taipei Univ Nursing & Hlth Sci, Sch Nursing, Taipei, Taiwan.
C3 National Yang Ming Chiao Tung University; National Taipei University of
   Nursing & Health Science (NTUNHS)
RP Yang, CY (corresponding author), 155,Sec 2,Linong St, Taipei 11221, Taiwan.
EM cyyang3@ym.edu.tw
RI Liu, Chieh-Yu/J-3789-2019; Yang, Chiu-Yueh/AEK-3524-2022
OI Lin, Shih-Pi/0000-0003-4070-8567; Yang, Chiu-Yueh/0000-0002-5907-5619
FU National Science Council of Taiwan [NSC 101-2410-H-010-012]
FX We thank all of the subjects who participated in this study and the
   three research assistants (Lee, J. C., Lin, C. Y., and Lin, C. P.) who
   helped with data collection. This study was supported by the National
   Science Council of Taiwan (NSC 101-2410-H-010-012).
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NR 36
TC 4
Z9 4
U1 0
U2 9
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1682-3141
EI 1948-965X
J9 J NURS RES
JI J. Nurs. Res.
PD JUN
PY 2018
VL 26
IS 3
BP 207
EP 215
DI 10.1097/jnr.0000000000000235
PG 9
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA GI8LD
UT WOS:000434775300009
PM 29016469
DA 2025-06-11
ER

PT J
AU Yu, JY
   Song, PG
   Perry, R
   Penfold, C
   Cooper, AR
AF Yu, Jinyue
   Song, Peige
   Perry, Rachel
   Penfold, Chris
   Cooper, Ashley R.
TI The Effectiveness of Green Tea or Green Tea Extract on Insulin
   Resistance and Glycemic Control in Type 2 Diabetes Mellitus: A
   Meta-Analysis
SO DIABETES & METABOLISM JOURNAL
LA English
DT Review
DE Diabetes mellitus; type 2; Glycemic control; Green tea; Insulin
   resistance; Meta-analysis
ID RANDOMIZED CONTROLLED-TRIAL; OXIDATIVE STRESS; GLUCOSE CONTROL;
   DOUBLE-BLIND; BLACK TEA; METABOLIC SYNDROME; CONSUMPTION; RISK;
   POLYPHENOL; SUPPLEMENTATION
AB Green tea or green tea extract (GT/GTE) has been demonstrated to reduce insulin resistance and improve glycemic control. However, evidence for this health beneficial effect is inconsistent. This systematic review evaluated the effect of GT/GTE on insulin resistance and glycemic control in people with pre-diabetes/type 2 diabetes mellitus (T2DM). Ovid MEDLINE, Embase, AMED, Web of Science, and the Cochrane Library were searched up to April 2017 for randomised controlled trials of participants with pre-diabetes or T2DM, where the intervention was GT/GTE. Meta-analysis was performed to assess the standardised mean difference (SMD) in biomarkers of insulin resistance and glycemic control between GT/GTE and placebo groups. Six studies (n=382) were pooled into random-effects meta-analysis. Overall, no differences were found between GT/GTE and the placebo for glycosylated hemoglobin (HbA1c: SMD, -0.32; 95% confidence interval [CI], -0.86 to 0.23), homeostatic model assessment for insulin resistance (HOMA-IR: SMD, 0.10; 95% CI, -0.17 to 0.38), fasting insulin (SMD, -0.25; 95% CI, -0.64 to 0.15), and fasting glucose (SMD, -0.10; 95% CI, -0.50 to 0.30). No evidence support the consumption of GT/GTE could reduce the levels of HbA1c, HOMA-IR, fasting insulin, or fasting glucose in people with pre-diabetes/T2DM. However, the studies included were small and of varying quality.
C1 [Yu, Jinyue] UCL, Sch Life & Med Sci, Div Med, London, England.
   [Song, Peige] Univ Edinburgh, Ctr Populat Hlth Sci, Edinburgh, Midlothian, Scotland.
   [Perry, Rachel; Penfold, Chris; Cooper, Ashley R.] Univ Bristol, NIHR Bristol Biomed Res Ctr, Nutr Theme, Bristol, Avon, England.
   [Cooper, Ashley R.] Univ Bristol, Sch Policy Studies, Ctr Exercise Nutr & Hlth Sci, Bristol, Avon, England.
C3 University of London; University College London; University of
   Edinburgh; University of Bristol; University of Bristol
RP Cooper, AR (corresponding author), Univ Bristol, Sch Policy Studies, Ctr Exercise Nutr & Hlth Sci, Bristol, Avon, England.
EM Ashley.Cooper@bristol.ac.uk
RI Yu, Jinyue/GMW-9904-2022; Song, Peige/AAG-6236-2019; Cooper,
   Ashley/D-9956-2014; Penfold, Chris/J-6147-2013
OI Yu, Jinyue/0000-0001-5182-3232; Cooper, Ashley/0000-0001-8644-3870;
   Penfold, Chris/0000-0001-8654-353X
FU National Institute for Health Research (NIHR) Bristol Nutrition
   Biomedical Research Unit based at University Hospitals Bristol NHS
   Foundation Trust; University of Bristol
FX The work of all Ashley R. Cooper and Rachel Perry was supported by the
   National Institute for Health Research (NIHR) Bristol Nutrition
   Biomedical Research Unit based at University Hospitals Bristol NHS
   Foundation Trust and the University of Bristol. The views expressed are
   those of the author(s) and not necessarily those of the NHS, the NIHR,
   or the Department of Health.
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NR 49
TC 52
Z9 56
U1 1
U2 33
PU KOREAN DIABETES ASSOC
PI SEOUL
PA 101-2104, LOTTE CASTLE PRES, 109 MAPO-DAERO, MAPO-GU, SEOUL, 04146,
   SOUTH KOREA
SN 2233-6079
EI 2233-6087
J9 DIABETES METAB J
JI Diabetes Metab. J.
PD AUG
PY 2017
VL 41
IS 4
BP 251
EP 262
DI 10.4093/dmj.2017.41.4.251
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA FH5OJ
UT WOS:000411216400002
PM 28868822
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Lu, PH
   Song, YL
   Hsu, CH
AF Lu, P. H.
   Song, Y. L.
   Hsu, C. H.
TI Ghrelin level negatively predicts quality of life in obese women
SO PSYCHOLOGY HEALTH & MEDICINE
LA English
DT Article
DE Ghrelin; obesity-related hormone peptide; quality of life; obesity
ID INSULIN-RESISTANCE; METABOLIC SYNDROME; PLASMA GHRELIN; HEALTH; STRESS;
   RELIABILITY; HOMEOSTASIS; OVERWEIGHT; DISORDERS; CHILDREN
AB A cross-sectional cohort study was conducted to investigate whether ghrelin level in obese women predicts the quality of life (QOL). A total of 307 subjects fulfilled the criteria: (1) age between 20 and 65years old, (2) body mass index 27kg/m(2) (3) waist circumference 80cm were enrolled in the study. All subjects were assigned to one of the plasma ghrelin level categories according to the quartiles. The median of age and BMI of the 307 obese women were 45 +/- 18years and 29.9 +/- 4.1kg/m(2), respectively. The main outcome evaluated is the associations of plasma ghrelin level and QOL, which were evaluated using multiple linear regression analysis. Results of linear trend test show significant statistical difference in plasma lipoproteins (triglyceride, cholesterol, HDL-cholestero and LDL-cholesterol = and levels of obesity-related hormone peptides, including leptin, adiponectin, insulin among quartiles of ghrelin. Multiple liner regression analysis of serum obesity-related hormone peptide level and QOL using stepwise method shows ghrelin concentration was the only predictor of QOL, including PCS-12 level (=-0.18, p=0.001), MCS-12 level (=-0.14, p=0.009), WHOQOL-BREF scores: physical (=-0.13, p=0.03), psychological (=-0.16, p=0.007), social (=-0.21, p=<0.001), and environmental (=-0.22, p=<0.001), after adjusting other factors for obese female subjects. This study demonstrated that ghrelin concentration is strongly associated with QOL level among obese women. Hence, ghrelin concentration might be a valuable marker to be monitored in obese women.
C1 [Lu, P. H.; Song, Y. L.; Hsu, C. H.] Natl Yang Ming Univ, Inst Tradit Med, Sch Med, Taipei, Taiwan.
   [Lu, P. H.] Far Eastern Mem Hosp, Dept Dermatol, New Taipei, Taiwan.
   [Hsu, C. H.] Taipei City Hosp, Branch Linsen & Chinese Med, Taipei, Taiwan.
C3 National Yang Ming Chiao Tung University; Far Eastern Memorial Hospital;
   Taipei City Hospital
RP Hsu, CH (corresponding author), Natl Yang Ming Univ, Inst Tradit Med, Sch Med, Taipei, Taiwan.; Hsu, CH (corresponding author), Taipei City Hosp, Branch Linsen & Chinese Med, Taipei, Taiwan.
EM owlherbs@yahoo.com.tw
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NR 37
TC 2
Z9 2
U1 0
U2 9
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 1354-8506
EI 1465-3966
J9 PSYCHOL HEALTH MED
JI Psychol. Health Med.
PY 2017
VL 22
IS 2
BP 162
EP 171
DI 10.1080/13548506.2016.1191654
PG 10
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA EE1PT
UT WOS:000389355200005
PM 27228455
DA 2025-06-11
ER

PT J
AU Reátegui, D
   Tornero, E
   Popescu, D
   Sastre, S
   Carnafort, M
   Gines, G
   Combalía, A
   Lozano, L
AF Reategui, Diego
   Tornero, Eduard
   Popescu, Dragos
   Sastre, Sergi
   Carnafort, Miguel
   Gines, Gracia
   Combalia, Andres
   Lozano, Luis
TI Postoperative hyperglycaemia control reduces postoperative complications
   in patients subject to total knee arthroplasty
SO KNEE
LA English
DT Article
DE Diabetes; Hyperglycaemia; Total knee arthroplasty; Glycated haemoglobin;
   Complications; Primary care physician
ID SURGICAL-SITE INFECTIONS; GLYCEMIC CONTROL; METABOLIC SYNDROME; TOTAL
   HIP; OUTCOMES; SURGERY; ASSOCIATION; REPLACEMENT; IMPACT; RISK
AB Background: The aim of our study was the early detection and treatment of patients with unknown alterations of the hydrocarbon metabolism subject to total knee arthroplasty in order to reduce the incidence of postoperative complications.
   Methods: Patients were classified as non-diabetic patients (group 1), diabetic patients (group 2) and patients with stress hyperglycaemia (group 3). The last two groups were recommended assessment by a primary care physician (PCP). After one year follow-up the groups were compared with respect to incidence of postoperative complications. The groups were also compared regarding the decrease or increase of HbA1c levels with the incidence of complications.
   Results: Of the 228 patients, 116 (50%) were included in group 1, 40 (17.5%) in group 2 and 72 (31.6%) in group 3. Patients that consulted their PCP presented lower medical complication rates than those who did not (9.2% vs. 26.4%, P = 0.020). Not being attended by a PCP was an independent predictive factor of medical complication (odds ratio (OR): 21.3; 95% confidence interval (95% CI): 4.6-98.5), surgical site infection (OR: 4.1; 95% CI: 1.1-15.0) and mechanical complication (OR: 5.0; 95% CI: 1.3-18.8). A decrease of HbAlc value was related to less medical systemic complications (7.3% vs. 24.2%, P = 0.035).
   Conclusions: Patients with hyperglycaemia during the postoperative total knee arthroplasty period, who are controlled by the PCP present lower incidence of complications. Decrease of HbA1c value during postoperative total knee arthroplasty period leads to a lower rate of medical complications. (C) 2016 Elsevier B.V. All rights reserved.
C1 [Reategui, Diego; Tornero, Eduard; Combalia, Andres] Hosp Clin Barcelona, Trauma & Orthopaed Dept, Barcelona, Spain.
   [Popescu, Dragos; Sastre, Sergi; Lozano, Luis] Hosp Clin Barcelona, Trauma & Orthopaed Dept, Knee Unit, Barcelona, Spain.
   [Carnafort, Miguel] Hosp Clin Barcelona, Dermatol & Med Inst, Dept Internal Med, Barcelona, Spain.
   [Gines, Gracia] Hosp Clin Barcelona, Trauma & Orthopaed Dept, Nursery Knee Unit, Barcelona, Spain.
C3 University of Barcelona; Hospital Clinic de Barcelona; University of
   Barcelona; Hospital Clinic de Barcelona; University of Barcelona;
   Hospital Clinic de Barcelona; University of Barcelona; Hospital Clinic
   de Barcelona
RP Reátegui, D (corresponding author), Hosp Clin Barcelona, Trauma & Orthopaed Dept, Barcelona, Spain.
EM diego_reategui@hotmail.com
RI Sastre, Sergi/IST-5980-2023; Camafort-Babkowski, Miguel/H-6310-2014
OI POPESCU, DRAGOS/0000-0002-1720-1883; Camafort-Babkowski,
   Miguel/0000-0002-8669-6410; Sastre, Sergi/0000-0002-4425-0074
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NR 39
TC 7
Z9 8
U1 0
U2 4
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0968-0160
EI 1873-5800
J9 KNEE
JI Knee
PD JAN
PY 2017
VL 24
IS 1
BP 128
EP 136
DI 10.1016/j.knee.2016.09.011
PG 9
WC Orthopedics; Sport Sciences; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Sport Sciences; Surgery
GA EM5OA
UT WOS:000395359800019
PM 27863976
DA 2025-06-11
ER

PT J
AU Eichelmann, F
   Schwingshackl, L
   Fedirko, V
   Aleksandrova, K
AF Eichelmann, F.
   Schwingshackl, L.
   Fedirko, V.
   Aleksandrova, K.
TI Effect of plant-based diets on obesity-related inflammatory profiles: a
   systematic review and meta-analysis of intervention trials
SO OBESITY REVIEWS
LA English
DT Review
DE Adipose-tissue inflammation; chronic disease; metabolic dysfunction;
   plant-based diets; prevention
ID C-REACTIVE PROTEIN; MEDITERRANEAN-STYLE DIET; TUMOR-NECROSIS-FACTOR;
   HEALTHY NORDIC DIET; METABOLIC SYNDROME; LOW-FAT; OXIDATIVE STRESS;
   CARDIOVASCULAR-DISEASE; INSULIN-RESISTANCE; WEIGHT-LOSS
AB Plant-based dietary interventions have been proposed to reduce obesity induced chronic low-grade inflammation and hence prevent chronic disease risk; however, human evidence remains unclear. This systematic review and meta-analysis of intervention trials aimed to assess the effect of plant-based diets on obesity-related inflammatory biomarker profiles. Medline, EMBASE and Cochrane Central Register of Controlled Trials (CENTRAL) were searched for articles published until January 2016 and mean differences in biomarkers of inflammatory status were assessed for: C-reactive protein (CRP), interleukin-6 (IL-6), tumour necrosis factor-alpha (TNF-?), soluble intercellular adhesion molecule 1 (sICAM), leptin, adiponectin and resistin. Of initially identified 2,583 publications, 29 met the meta-analysis inclusion criteria [a total of 2,689 participants]. Consumption of plant-based diets was associated with a reduction in the mean concentrations of the following biomarkers: CRP [effect size, -0.55mg/l, 95% confidence intervals (CI): -0.78; -0.32, I-2=94.4%], IL-6 [effect size, -0.25ng/l, 95% CI: -0.56; 0.06, I-2=74%], and, to some degree, sICAM (-25.07ng/ml [95% CI: -52.32; 2.17, I-2=93.2%]). No substantial effects were revealed for TNF-?, resistin, adiponectin and leptin. Plant-based diets are associated with an improvement in obesity-related inflammatory profiles and could provide means for therapy and prevention of chronic disease risk.
C1 [Eichelmann, F.; Aleksandrova, K.] German Inst Human Nutr Potsdam Rehbrucke, Dept Epidemiol, Nutr Immun & Metab Start Up Lab, Arthur Scheunert Allee 114-116, D-14558 Nuthetal, Germany.
   [Schwingshackl, L.] German Inst Human Nutr Potsdam Rehbrucke, Dept Epidemiol, Nuthetal, Germany.
   [Fedirko, V.] Emory Univ, Dept Epidemiol, Rollins Sch Publ Hlth, Winship Canc Inst, Atlanta, GA 30322 USA.
C3 Leibniz Association; Deutsches Institut fur Ernahrungsforschung
   Potsdam-Rehbrucke (DIfE); Leibniz Association; Deutsches Institut fur
   Ernahrungsforschung Potsdam-Rehbrucke (DIfE); Emory University; Rollins
   School Public Health
RP Aleksandrova, K (corresponding author), German Inst Human Nutr Potsdam Rehbrucke, Dept Epidemiol, Nutr Immun & Metab Start Up Lab, Arthur Scheunert Allee 114-116, D-14558 Nuthetal, Germany.
EM krasimira.aleksandrova@dife.de
RI Eichelmann, Fabian/M-9039-2016; Schwingshackl, Lukas/AAC-4119-2019;
   Schwingshackl, Lukas/B-9220-2013
OI Aleksandrova, Krasimira/0000-0002-1275-1827; Eichelmann,
   Fabian/0000-0002-3975-5596; Schwingshackl, Lukas/0000-0003-3407-7594
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NR 71
TC 148
Z9 160
U1 0
U2 52
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1467-7881
EI 1467-789X
J9 OBES REV
JI Obes. Rev.
PD NOV
PY 2016
VL 17
IS 11
BP 1067
EP 1079
DI 10.1111/obr.12439
PG 13
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA DZ9RV
UT WOS:000386217400005
PM 27405372
DA 2025-06-11
ER

PT J
AU Panahi, Y
   Kianpour, P
   Mohtashami, R
   Jafari, R
   Simental-Mendía, LE
   Sahebkar, A
AF Panahi, Yunes
   Kianpour, Parisa
   Mohtashami, Reza
   Jafari, Ramezan
   Simental-Mendia, Luis E.
   Sahebkar, Amirhossein
TI Curcumin Lowers Serum Lipids and Uric Acid in Subjects With Nonalcoholic
   Fatty Liver Disease: A Randomized Controlled Trial
SO JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
LA English
DT Article
DE curcumin; cholesterol; triglycerides; hyperglycemia; urate
ID PLACEBO-CONTROLLED TRIAL; QUALITY-OF-LIFE; CHRONIC PULMONARY
   COMPLICATIONS; SYSTEMIC OXIDATIVE STRESS; METABOLIC SYNDROME;
   DOUBLE-BLIND; SULFUR MUSTARD; PIPERINE COMBINATION; PHARMACOLOGICAL
   ACTIONS; INDUCED HYPERLIPIDEMIA
AB Background: Nonalcoholic fatty liver disease (NAFLD) is one of the most common hepatic diseases in the general adult population. Dyslipidemia, hyperuricemia, and insulin resistance are common risk factors and accompanying features of NAFLD. Curcumin is a dietary natural product with beneficial metabolic effects relevant to the treatment of NAFLD.
   Aim: To assess the effects of curcumin on metabolic profile in subjects with NAFLD.
   Methods: Patients diagnosed with NAFLD (grades 1-3; according to liver sonography) were randomly assigned to curcumin (1000 mg/d in 2 divided doses) (n = 50) or control (n = 52) group for a period of 8 weeks. All patients received dietary and lifestyle advises before the start of trial. Anthropometric measurements, lipid profile, glucose, insulin, glycated hemoglobin, and uric acid concentrations were measured at baseline and after 8 weeks of follow-up.
   Results: Eighty-seven subjects (n = 44 and 43 in the curcumin and control group, respectively) completed the trial. Supplementation with curcumin was associated with a reduction in serum levels of total cholesterol (P < 0.001), low-density lipoprotein cholesterol (P < 0.001), triglycerides (P < 0.001), non-high-density lipoprotein cholesterol (P < 0.001), and uric acid (P < 0.001), whereas serum levels of high-density lipoprotein cholesterol and glucose control parameters remained unaltered. Curcumin was safe and well tolerated during this study.
   Conclusion: Results of the present trial suggest that curcumin supplementation reduces serum lipids and uric acid concentrations in patients with NAFLD.
C1 [Panahi, Yunes] Baqiyatallah Univ Med Sci, Chem Injuries Res Ctr, Tehran, Iran.
   [Kianpour, Parisa] Islamic Azad Univ, Pharmaceut Sci Branch, POB 19945-581, Tehran, Iran.
   [Mohtashami, Reza] Baqiyatallah Univ Med Sci, Med Quran & Hlth Res Ctr, Tehran, Iran.
   [Jafari, Ramezan] Baqiyatallah Univ Med Sci, Tehran, Iran.
   [Simental-Mendia, Luis E.] Mexican Social Secur Inst, Biomed Res Unit, Durango, CO, Mexico.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Biotechnol Res Ctr, Mashhad, Iran.
   [Sahebkar, Amirhossein] Univ Western Australia, Sch Med & Pharmacol, Royal Perth Hosp, Metab Res Ctr, Perth, WA, Australia.
C3 Baqiyatallah University of Medical Sciences (BMSU); Islamic Azad
   University; Baqiyatallah University of Medical Sciences (BMSU);
   Baqiyatallah University of Medical Sciences (BMSU); Instituto Mexicano
   del Seguro Social; Mashhad University of Medical Sciences; University of
   Western Australia; East Metropolitan Health Service; Royal Perth
   Hospital
RP Kianpour, P (corresponding author), Islamic Azad Univ, Pharmaceut Sci Branch, POB 19945-581, Tehran, Iran.; Sahebkar, A (corresponding author), Mashhad Univ Med Sci, Sch Med, Dept Med Biotechnol, POB 91779-48564, Mashhad, Iran.
EM pk.pioneer1@yahoo.com; sahebkara@mums.ac.ir
RI jafari, ramezan/V-4938-2019; Sahebkar, Amirhossein/B-5124-2018;
   Mohtashami, Reza/A-6561-2019; pourfakhr, pejman/E-4393-2019
OI Panahi, Yunes/0000-0002-2504-8356; Mohtashami, Reza/0000-0002-4087-6061;
   pourfakhr, pejman/0000-0003-4071-5900; Jafari,
   Ramezan/0000-0003-1099-4259
FU Baqiyatallah University of Medical Sciences (Tehran, Iran); Indena SpA
   (Milan, Italy)
FX The authors are grateful for the supports provided by the Baqiyatallah
   University of Medical Sciences (Tehran, Iran) and Indena SpA (Milan,
   Italy).
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NR 53
TC 207
Z9 208
U1 12
U2 107
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0160-2446
EI 1533-4023
J9 J CARDIOVASC PHARM
JI J. Cardiovasc. Pharmacol.
PD SEP
PY 2016
VL 68
IS 3
BP 223
EP 229
DI 10.1097/FJC.0000000000000406
PG 7
WC Cardiac & Cardiovascular Systems; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Pharmacology & Pharmacy
GA DW9QC
UT WOS:000383995700006
PM 27124606
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Carraro, JCC
   Hermsdorff, HHM
   Mansego, ML
   Zulet, MA
   Milagro, FI
   Bressan, J
   Martínez, JA
AF Cardoso Carraro, Julia Cristina
   Miranda Hermsdorff, Helen Hermana
   Luisa Mansego, Maria
   Angeles Zulet, Maria
   Milagro, Fermin I.
   Bressan, Josefina
   Alfredo Martinez, J.
TI Higher Fruit Intake Is Related to TNF-α Hypomethylation and
   Better Glucose Tolerance in Healthy Subjects
SO JOURNAL OF NUTRIGENETICS AND NUTRIGENOMICS
LA English
DT Article
DE Biomarker; Inflammation; Epigenetics; DNA methylation; Diet; Fiber;
   Vitamin C
ID OXIDATIVE STRESS MARKERS; DIETARY FIBER INTAKE; MIDDLE-AGED MEN;
   METABOLIC SYNDROME; DNA METHYLATION; GENE-EXPRESSION; VEGETABLE INTAKE;
   YOUNG-ADULTS; PROMOTER METHYLATION; EPIGENETIC REGULATION
AB Background/Aim: This study hypothesized an association between healthy dietary patterns, hypermethylation of the tumor necrosis factor-alpha (TNF-alpha) promoter and decreased risk of metabolic changes. Methods: Forty normal-weight young women were involved in this cross-sectional study. DNA was isolated from white blood cells, and CpG site methylation in TNF-alpha was analyzed by Sequenom EpiTyper. The quality of the diet was assessed by Healthy Eating Index (HEI-2005). Results: Contradicting our hypothesis, HEI-2005 score was negatively associated with CpG5 (r = -0.460, p = 0.003) and TNF-alpha total methylation (r = -0.355, p = 0.026). A higher intake of fruits was related to lower insulin, HOMA-IR, and TNF-alpha methylation. No other dietary pattern was related to TNF-alpha methylation. TNF-alpha total methylation correlated positively with systolic blood pressure (r = 0.323; p = 0.042) and CpG5 methylation with body mass index (r = 0.333, p = 0.036). Furthermore, fiber intake was negatively associated with the CpG5 (r = -0.324, p = 0.041) and TNF-alpha total methylation (r = -0.434, p = 0.005), whereas vitamin C intake was negatively associated with TNF-alpha total methylation (r = -0.411, p = 0.009). Intakes of apples and citrus fruits were negatively associated with TNF-alpha total methylation. Conclusion: A healthy dietary pattern and higher fruit intake (particularly apples and citrus fruits) were related to better glucose tolerance in healthy subjects, which could be mediated by lower TNF-alpha methylation. (C) 2016 S. Karger AG, Basel
C1 [Cardoso Carraro, Julia Cristina] Univ Fed Ouro Preto, Dept Clin & Social Nutr, Ouro Preto, MG, Brazil.
   [Miranda Hermsdorff, Helen Hermana; Bressan, Josefina] Univ Fed Vicosa, Dept Nutr & Hlth, Vicosa, MG, Brazil.
   [Luisa Mansego, Maria; Angeles Zulet, Maria; Milagro, Fermin I.; Alfredo Martinez, J.] Univ Navarra, Ctr Nutr Res, Dept Nutr Food Sci & Physiol, Pamplona, Spain.
   [Angeles Zulet, Maria; Alfredo Martinez, J.] Navarra Inst Hlth Res, IdiSNA, Pamplona, Spain.
   [Angeles Zulet, Maria; Milagro, Fermin I.; Alfredo Martinez, J.] Carlos III Inst Hlth, CIBERobn, Ctr Invest Biomed Red Fisiopatol Obesidad & Nutr, Madrid, Spain.
C3 Universidade Federal de Ouro Preto; Universidade Federal de Vicosa;
   University of Navarra; University of Navarra; CIBER - Centro de
   Investigacion Biomedica en Red; CIBEROBN; Instituto de Salud Carlos III
RP Martínez, JA (corresponding author), Univ Navarra, C Irunlarrea 1, ES-31008 Pamplona, Spain.
EM jalfmtz@unav.es
RI Milagro, Fermin/F-2315-2015; MANSEGO, MARIA/A-5687-2011; Bressan,
   Josefina/A-2598-2009; Martínez, J./K-8709-2014; Zulet, M.
   Angeles/H-1317-2017; Hermsdorff, Helen Hermana Miranda/H-4525-2015
OI Bressan, Josefina/0000-0002-4993-9436; Milagro, Fermin
   I./0000-0002-3228-9916; Zulet, M. Angeles/0000-0002-3926-0892;
   Hermsdorff, Helen Hermana Miranda/0000-0002-4441-6572
FU Spanish Ministry of Economy and Competitiveness [AGL2013-4554-R]; Carlos
   III Institute of Health (CIBERobn)
FX We wish to thank the physician Blanca E. Martinez de Morentin, the nurse
   Salome Perez, and the technician Veronica Ciaurriz. We also thank Capes
   for a PhD scholarship awarded to J.C.C. Carraro. This work was supported
   by the Spanish Ministry of Economy and Competitiveness (ref.
   AGL2013-4554-R) and Carlos III Institute of Health (CIBERobn).
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NR 77
TC 19
Z9 21
U1 0
U2 12
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1661-6499
EI 1661-6758
J9 J NUTRIGENET NUTRIGE
JI J. Nutrigenet. Nutrigenomics
PY 2016
VL 9
IS 2-4
BP 95
EP 105
DI 10.1159/000448101
PG 11
WC Genetics & Heredity; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Genetics & Heredity; Nutrition & Dietetics
GA EC2SE
UT WOS:000387973400003
PM 27467584
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Carreira, VS
   Fan, YX
   Kurita, H
   Wang, Q
   Ko, CI
   Naticchioni, M
   Jiang, M
   Koch, S
   Zhang, X
   Biesiada, J
   Medvedovic, M
   Xia, Y
   Rubinstein, J
   Puga, A
AF Carreira, Vinicius S.
   Fan, Yunxia
   Kurita, Hisaka
   Wang, Qin
   Ko, Chia-I
   Naticchioni, Midi
   Jiang, Min
   Koch, Sheryl
   Zhang, Xiang
   Biesiada, Jacek
   Medvedovic, Mario
   Xia, Ying
   Rubinstein, Jack
   Puga, Alvaro
TI Disruption of Ah Receptor Signaling during Mouse Development Leads to
   Abnormal Cardiac Structure and Function in the Adult
SO PLOS ONE
LA English
DT Article
ID ARYL-HYDROCARBON RECEPTOR; CONGENITAL HEART-DISEASE; METABOLIC SYNDROME;
   GENE-EXPRESSION; BLOOD-PRESSURE; TCDD; MUTATIONS; FETAL;
   2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN; PHOSPHOLAMBAN
AB The Developmental Origins of Health and Disease (DOHaD) Theory proposes that the environment encountered during fetal life and infancy permanently shapes tissue physiology and homeostasis such that damage resulting from maternal stress, poor nutrition or exposure to environmental agents may be at the heart of adult onset disease. Interference with endogenous developmental functions of the aryl hydrocarbon receptor (AHR), either by gene ablation or by exposure in utero to 2,3,7,8-tetrachlorodibenzo- p-dioxin (TCDD), a potent AHR ligand, causes structural, molecular and functional cardiac abnormalities and altered heart physiology in mouse embryos. To test if embryonic effects progress into an adult phenotype, we investigated whether Ahr ablation or TCDD exposure in utero resulted in cardiac abnormalities in adult mice long after removal of the agent. Ten-months old adult Ahr(-/-) and in utero TCDD-exposed Ahr(+/+) mice showed sexually dimorphic abnormal cardiovascular phenotypes characterized by echocardiographic findings of hypertrophy, ventricular dilation and increased heart weight, resting heart rate and systolic and mean blood pressure, and decreased exercise tolerance. Underlying these effects, genes in signaling networks related to cardiac hypertrophy and mitochondrial function were differentially expressed. Cardiac dysfunction in mouse embryos resulting from AHR signaling disruption seems to progress into abnormal cardiac structure and function that predispose adults to cardiac disease, but while embryonic dysfunction is equally robust in males and females, the adult abnormalities are more prevalent in females, with the highest severity in Ahr(-/-) females. The findings reported here underscore the conclusion that AHR signaling in the developing heart is one potential target of environmental factors associated with cardiovascular disease.
C1 [Carreira, Vinicius S.; Fan, Yunxia; Kurita, Hisaka; Wang, Qin; Ko, Chia-I; Zhang, Xiang; Biesiada, Jacek; Medvedovic, Mario; Xia, Ying; Puga, Alvaro] Univ Cincinnati, Coll Med, Dept Environm Hlth, Cincinnati, OH 45267 USA.
   [Carreira, Vinicius S.; Fan, Yunxia; Kurita, Hisaka; Wang, Qin; Ko, Chia-I; Zhang, Xiang; Biesiada, Jacek; Medvedovic, Mario; Xia, Ying; Puga, Alvaro] Univ Cincinnati, Coll Med, Ctr Environm Genet, Cincinnati, OH 45267 USA.
   [Naticchioni, Midi; Jiang, Min; Koch, Sheryl; Rubinstein, Jack] Univ Cincinnati, Coll Med, Dept Internal Med, Div Cardiovasc Hlth & Dis, Cincinnati, OH 45267 USA.
C3 University System of Ohio; University of Cincinnati; University System
   of Ohio; University of Cincinnati; University System of Ohio; University
   of Cincinnati
RP Puga, A (corresponding author), Univ Cincinnati, Coll Med, Dept Environm Hlth, Cincinnati, OH 45267 USA.
EM Alvaro.Puga@uc.edu
RI Kurita, Hisaka/ABA-3983-2020; Biesiada, Jacek/I-2844-2018
OI Biesiada, Jacek/0000-0003-0435-2225; Carreira,
   Vinicius/0000-0003-4524-0510; Rubinstein, Jack/0000-0002-8811-1551;
   Kurita, Hisaka/0000-0001-6582-3129
FU National Institute of Environmental Health Sciences (NIEHS) [R01
   ES06273, R01 ES024744, R01 ES10807]; NIEHS Center for Environmental
   Genetics [P30 ES06096]; NIEHS Gene Environment Interactions Training
   Grant [T32 ES016646]
FX Funding: This research was supported by National Institute of
   Environmental Health Sciences (NIEHS) grants R01 ES06273, R01 ES024744,
   and R01 ES10807, and by the NIEHS Center for Environmental Genetics
   grant P30 ES06096. V.S.C. was supported by NIEHS Gene Environment
   Interactions Training Grant T32 ES016646. The funders had no role in
   study design, data collection and analysis, decision to publish, or
   preparation of the manuscript.
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NR 71
TC 39
Z9 47
U1 0
U2 18
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD NOV 10
PY 2015
VL 10
IS 11
AR e0142440
DI 10.1371/journal.pone.0142440
PG 21
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA CV7CT
UT WOS:000364430700106
PM 26555816
OA Green Submitted, gold, Green Published
DA 2025-06-11
ER

PT J
AU Pereira, S
   Breen, DM
   Naassan, AE
   Wang, PYT
   Uchino, H
   Fantus, IG
   Carpentier, AC
   Gutierrez-Juarez, R
   Brindley, DN
   Lam, TKT
   Giacca, A
AF Pereira, Sandra
   Breen, Danna M.
   Naassan, Anthony E.
   Wang, Penny Y. T.
   Uchino, Hiroshi
   Fantus, I. George
   Carpentier, Andre C.
   Gutierrez-Juarez, Roger
   Brindley, David N.
   Lam, Tony K. T.
   Giacca, Adria
TI In vivo effects of polyunsaturated, monounsaturated, and saturated fatty
   acids on hepatic and peripheral insulin sensitivity
SO METABOLISM-CLINICAL AND EXPERIMENTAL
LA English
DT Article
DE Fat; Hyperinsulinemic-euglycemic clamp; Liver
ID HIGH-CARBOHYDRATE DIET; PKC-DELTA; METABOLIC SYNDROME; OXIDATIVE STRESS;
   POTENTIAL ROLE; RESISTANCE; HUMANS; WOMEN; LIPOPROTEIN; SECRETION
AB Objective. Free fatty acids (FFAs) cause insulin resistance and are often elevated in obesity. Chronic ingestion of diets rich in saturated fat induces more insulin resistance than diets rich in unsaturated fat, however, it remains unclear whether different FFAs cause distinct levels of insulin resistance in the short-term, which is relevant to the feeding and fasting cycle. Protein kinase C (PKC)-delta is implicated in hepatic insulin resistance. Therefore, we investigated the effects of short-term elevation of fatty acids with different degrees of unsaturation on hepatic insulin action and liver PKC-delta membrane translocation, a marker of activation.
   Materials/Methods. Triglyceride emulsions of Soybean Oil + Heparin (polyunsaturated (POLY)), Olive Oil + Heparin (monounsaturated (MONO)), Lard Oil + Heparin (saturated (SATU)), or saline (SAL) were infused intravenously for 7 h to elevate plasma FFA concentrations similar to 3-4 fold in rats. During the last 2 h of infusion, a hyperinsulinemic-euglycemic clamp with tritiated glucose methodology was performed to examine hepatic and peripheral insulin sensitivity.
   Results. Surprisingly, SATU, MONO, and POLY impaired peripheral insulin sensitivity (glucose utilization divided by insulin) to a similar extent. Furthermore, all lipids induced a similar degree of hepatic insulin resistance compared to SAL. Although there were changes in hepatic content of lipid metabolites, there were no significant differences in liver PKC-delta membrane translocation across fat groups.
   Conclusions. In summary, in the short-term, FFAs with different degrees of unsaturation impair peripheral insulin sensitivity and induce hepatic insulin resistance as well as hepatic PKC-delta translocation to the same extent. (C) 2015 Elsevier Inc. All rights reserved.
C1 [Pereira, Sandra; Breen, Danna M.; Naassan, Anthony E.; Wang, Penny Y. T.; Uchino, Hiroshi; Fantus, I. George; Lam, Tony K. T.; Giacca, Adria] Univ Toronto, Dept Physiol, Toronto, ON M5S 1A8, Canada.
   [Fantus, I. George; Giacca, Adria] Univ Toronto, Dept Med, Toronto, ON M5G 2C4, Canada.
   [Carpentier, Andre C.] Univ Sherbrooke, Dept Med, Div Endocrinol, Sherbrooke, PQ J1H 5N4, Canada.
   [Gutierrez-Juarez, Roger] Albert Einstein Coll Med, Dept Med, Diabet Res Ctr, Bronx, NY 10461 USA.
   [Brindley, David N.] Univ Alberta, Dept Biochem, Signal Transduct Res Grp, Heritage Med Res Ctr 357, Edmonton, AB T6G 2S2, Canada.
   [Giacca, Adria] Univ Toronto, Inst Med Sci, Toronto, ON M5S 1A8, Canada.
C3 University of Toronto; University of Toronto; University of Sherbrooke;
   Montefiore Medical Center; Albert Einstein College of Medicine; Yeshiva
   University; University of Alberta; University of Toronto
RP Giacca, A (corresponding author), Univ Toronto, Dept Physiol, Med Sci Bldg,Room 3336,1 Kings Coll Circle, Toronto, ON M5S 1A8, Canada.
EM sandra.pereira@mail.utoronto.ca; dbreensawatzky@gmail.com;
   anthony.naassan@gmail.com; shyuron@hotmail.com;
   h.uchino@med.toho-u.ac.jp; gfantus@mtsinai.on.ca;
   andre.carpentier@usherbrooke.ca; roger.gutierrez@einstein.yu.edu;
   david.brindley@ualberta.ca; tlam@uhnresearch.ca;
   adria.giacca@utoronto.ca
RI Fantus, Ivan/E-8973-2010; Gutierrez-Juarez, Roger/IST-9343-2023
FU Canadian Institutes of Health Research [MOP-89929]
FX Funding for this work was obtained from a grant from the Canadian
   Institutes of Health Research (MOP-89929, entitled "Mechanism of
   fat-induced hepatic insulin resistance") awarded to A. Giacca.
CR [Anonymous], 2014, FATTY ACID COMPOSITI
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NR 41
TC 21
Z9 23
U1 1
U2 20
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0026-0495
EI 1532-8600
J9 METABOLISM
JI Metab.-Clin. Exp.
PD FEB
PY 2015
VL 64
IS 2
BP 315
EP 322
DI 10.1016/j.metabol.2014.10.019
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA AY5CG
UT WOS:000347590300020
PM 25467844
DA 2025-06-11
ER

PT J
AU Cappelli, AP
   Zoppi, CC
   Barbosa-Sampaio, HC
   Costa, JM
   Protzek, AO
   Morato, PN
   Boschero, AC
   Carneiro, EM
AF Cappelli, Ana P.
   Zoppi, Claudio C.
   Barbosa-Sampaio, Helena C.
   Costa-, Jose M., Jr.
   Protzek, Andre O.
   Morato, Priscila N.
   Boschero, Antonio C.
   Carneiro, Everardo M.
TI Taurine-induced insulin signalling improvement of obese malnourished
   mice is associated with redox balance and protein phosphatases activity
   modulation
SO LIVER INTERNATIONAL
LA English
DT Article
DE PTEN; hydrogen peroxide; antioxidant enzymes; liver; PTP1B
ID OXIDATIVE STRESS; TYROSINE PHOSPHATASES; GROWTH TRAJECTORIES; METABOLIC
   SYNDROME; REACTIVE OXYGEN; GLUCOSE; RATS; PHOSPHORYLATION; RESISTANCE;
   MUSCLE
AB Background & Aims
   Obese protein malnourished mice display liver insulin resistance and taurine (TAU) seems to attenuate this effect. The association between early-life malnutrition and hepatic redox balance in diet-induced insulin resistance is unknown. We investigated TAU supplementation effects upon liver redox state and insulin signalling in obese protein malnourished mice.
   Methods
   Weaned male C57BL-6 mice were fed a control (14% protein - C) or a protein-restricted diet (6% protein - R) for 6weeks. Afterwards, mice received a high-fat diet (34% fat - HFD) for 8weeks (CH - RH). Half of the HFD-mice were supplemented with TAU (5%) throughout the treatment (CHT - RHT). Body and tissues' weight, respiratory quotient (RQ), glucose tolerance and insulin sensitivity, hepatic oxidant and antioxidant markers and insulin cascade proteins were assessed.
   Results
   Protein restriction leads to typical features whereas HFD was able to induce a catch-up growth in RH. HFD-groups showed higher energy intake and adiposity, lower energy expenditure and altered RQ. Glucose tolerance and insulin sensitivity were impaired in HFD-groups and TAU attenuated these effects. H2O2 content was increased in CHT and RHT despite no differences in antioxidant enzymes and GSH concentration. AKT and PTEN phosphorylation were significantly increased in CHT but not in RHT.
   Conclusion
   Our data provide evidence for an association between TAU-induced improved glycaemic control because of PTEN inactivation and higher AKT phosphorylation. These effects seem to be related with altered hepatic redox balance in obese mice, and this effect is impaired by protein malnutrition.
C1 [Cappelli, Ana P.; Zoppi, Claudio C.; Barbosa-Sampaio, Helena C.; Costa-, Jose M., Jr.; Protzek, Andre O.; Morato, Priscila N.; Boschero, Antonio C.; Carneiro, Everardo M.] State Univ Campinas UNICAMP, Inst Biol, Dept Struct & Funct Biol, BR-13083865 Campinas, SP, Brazil.
C3 Universidade Estadual de Campinas
RP Carneiro, EM (corresponding author), State Univ Campinas UNICAMP, Inst Biol, Dept Struct & Funct Biol, POB 6109, BR-13083865 Campinas, SP, Brazil.
EM emc@unicamp.br
RI Carneiro, Everardo/D-4758-2012; Cappelli, Ana/I-1357-2015; Morato,
   Priscila/AAN-6178-2021; costa, jose/L-9753-2016; Boschero,
   Antonio/O-7525-2014; Barbosa-Sampaio, Helena Cristina/B-7083-2015;
   Barbosa, Helena/AAJ-5572-2021
OI Magalhaes Carneiro, Everardo/0000-0003-3212-369X; Barbosa-Sampaio,
   Helena Cristina/0000-0002-5244-889X; Protzek, andre/0000-0002-0040-7068;
   Barbosa, Helena/0000-0002-8151-5959
FU FAPESP; CNPq; National Institute of Obesity and Diabetes (NICTOD); CEPID
FX FAPESP, CNPq, National Institute of Obesity and Diabetes (NICTOD) and
   CEPID grants are acknowledged here.
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NR 42
TC 23
Z9 23
U1 0
U2 8
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1478-3223
EI 1478-3231
J9 LIVER INT
JI Liver Int.
PD MAY
PY 2014
VL 34
IS 5
BP 771
EP 783
DI 10.1111/liv.12291
PG 13
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA AE2UP
UT WOS:000333828900016
PM 23998525
DA 2025-06-11
ER

PT J
AU Tahara, N
   Yamagishi, S
   Mizoguchi, M
   Tahara, A
   Imaizumi, T
AF Tahara, Nobuhiro
   Yamagishi, Sho-ichi
   Mizoguchi, Minori
   Tahara, Atsuko
   Imaizumi, Tsutomu
TI Pioglitazone Decreases Asymmetric Dimethylarginine Levels in Patients
   with Impaired Glucose Tolerance or Type 2 Diabetes
SO REJUVENATION RESEARCH
LA English
DT Article
ID GLYCATION END-PRODUCTS; OXIDE SYNTHASE INHIBITOR; RECEPTOR-GAMMA
   ACTIVATION; C-REACTIVE PROTEIN; NITRIC-OXIDE; SOLUBLE RECEPTOR;
   ENDOTHELIAL DYSFUNCTION; MYOCARDIAL-INFARCTION; METABOLIC SYNDROME;
   OXIDATIVE STRESS
AB Background and Aims: Asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase, is a biomarker and mediator of cardiovascular disease in patients with impaired glucose tolerance (IGT) or diabetes mellitus (DM). Advanced glycation end products (AGEs) and their receptor (RAGE) axis is involved in ADMA generation as well. However, it remains unclear whether pioglitazone could decrease ADMA levels by reducing RAGE expression in humans.
   Design and Methods: Forty-eight IGT or type 2 DM (T2DM) patients were assigned to receive either pioglitazone (n = 29) or glimepiride (n = 19) and evaluated at baseline and 16 weeks of follow-up. We compared the effects of pioglitazone and glimepride on ADMA and soluble form of RAGE (sRAGE) levels and then studied whether the changes in serum ADMA level (Delta ADMA) after treatment with pioglitazone were correlated with Delta sRAGE. We further examined which Delta clinical variables were independently associated with Delta ADMA.
   Results: After 16-week treatments, fasting plasma glucose and glycated hemoglobin (HbA1c) values were comparably reduced in both groups. Compared with glimepiride, pioglitazone treatment significantly decreased ADMA levels and improved insulin sensitivity, while it elevated high-density lipoprotein cholesterol (HDL-C) and sRAGE values and increased body weight and waist circumference. In multiple stepwise regression analysis, log-transformed Delta fibronectin were a sole independent determinant of log-transformed Delta ADMA (r=-0.551, R-2 = 0.303).
   Conclusions: This study demonstrated that pioglitazone decreased serum ADMA levels in a glucose-lowering independent manner. Elevation of fibronectin by pioglitazone may contribute to the reduction of serum levels of ADMA in IGT or T2DM subjects, thus playing a protective role against cardiovascular disease.
C1 [Tahara, Nobuhiro; Mizoguchi, Minori; Tahara, Atsuko; Imaizumi, Tsutomu] Kurume Univ, Sch Med, Dept Med, Div Cardiovasc Med, Kurume, Fukuoka 8300011, Japan.
   [Yamagishi, Sho-ichi] Kurume Univ, Sch Med, Dept Pathophysiol & Therapeut Diabet Vasc Complic, Kurume, Fukuoka 8300011, Japan.
C3 Kurume University; Kurume University
RP Yamagishi, S (corresponding author), Kurume Univ, Sch Med, Dept Pathophysiol & Therapeut Diabet Vasc Complic, Kurume, Fukuoka 8300011, Japan.
EM shoichi@med.kurume-u.ac.jp
FU MEXT-Supported Program for the Strategic Research Foundation at Private
   Universities; Ministry of Education, Culture, Sports, Science and
   Technology (MEXT); Ministry of Education, Culture, Sports, Science, and
   Technology of Japan [22390111]; Grants-in-Aid for Scientific Research
   [23591072, 22390111] Funding Source: KAKEN
FX This work was supported in part by the MEXT-Supported Program for the
   Strategic Research Foundation at Private Universities, the Ministry of
   Education, Culture, Sports, Science and Technology (MEXT) (S.Y.) and by
   Grants-in-Aid for Scientific Research (B) 22390111 (S.Y.) from the
   Ministry of Education, Culture, Sports, Science, and Technology of
   Japan.
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NR 41
TC 11
Z9 11
U1 0
U2 2
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1549-1684
EI 1557-8577
J9 REJUV RES
JI Rejuv. Res.
PD OCT
PY 2013
VL 16
IS 5
BP 344
EP 351
DI 10.1089/rej.2013.1434
PG 8
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA 300JU
UT WOS:000330461000002
PM 23777507
DA 2025-06-11
ER

PT J
AU Zhu, LX
   Baker, SS
   Gill, C
   Liu, WS
   Alkhouri, R
   Baker, RD
   Gill, SR
AF Zhu, Lixin
   Baker, Susan S.
   Gill, Chelsea
   Liu, Wensheng
   Alkhouri, Razan
   Baker, Robert D.
   Gill, Steven R.
TI Characterization of Gut Microbiomes in Nonalcoholic Steatohepatitis
   (NASH) Patients: A Connection Between Endogenous Alcohol and NASH
SO HEPATOLOGY
LA English
DT Article
ID FATTY LIVER-DISEASE; ESCHERICHIA-COLI; INTESTINAL PERMEABILITY;
   UNITED-STATES; ETHANOL; PATHOGENESIS; EXPRESSION; FREQUENCY; OBESITY;
   MICE
AB Nonalcoholic steatohepatitis (NASH) is a serious liver disease associated with obesity. Characterized by metabolic syndrome, hepatic steatosis, and liver inflammation, NASH is believed to be under the influence of the gut microflora. Here, the composition of gut bacterial communities of NASH, obese, and healthy children was determined by 16S ribosomal RNA pyrosequencing. In addition, peripheral blood ethanol was analyzed to monitor endogenous ethanol production of patients and healthy controls. UniFrac-based principle coordinates analysis indicated that most of the microbiome samples clustered by disease status. Each group was associated with a unique pattern of enterotypes. Differences were abundant at phylum, family, and genus levels between healthy subjects and obese patients (with or without NASH), and relatively fewer differences were observed between obese and the NASH microbiomes. Among those taxa with greater than 1% representation in any of the disease groups, Proteobacteria, Enterobacteriaceae, and Escherichia were the only phylum, family and genus types exhibiting significant difference between obese and NASH microbiomes. Similar blood-ethanol concentrations were observed between healthy subjects and obese non-NASH patients, but NASH patients exhibited significantly elevated blood ethanol levels. Conclusions: The increased abundance of alcohol-producing bacteria in NASH microbiomes, elevated blood-ethanol concentration in NASH patients, and the well-established role of alcohol metabolism in oxidative stress and, consequently, liver inflammation suggest a role for alcohol-producing microbiota in the pathogenesis of NASH. We postulate that the distinct composition of the gut microbiome among NASH, obese, and healthy controls could offer a target for intervention or a marker for disease. (HEPATOLOGY 2013;57:601-609)
C1 [Zhu, Lixin; Baker, Susan S.; Liu, Wensheng; Alkhouri, Razan; Baker, Robert D.] SUNY Buffalo, Dept Pediat, Digest Dis & Nutr Ctr, Buffalo, NY 14214 USA.
   [Gill, Chelsea; Gill, Steven R.] Univ Rochester, Dept Microbiol & Immunol, Rochester, NY USA.
C3 State University of New York (SUNY) System; University at Buffalo, SUNY;
   University of Rochester
RP Zhu, LX (corresponding author), SUNY Buffalo, Dept Pediat, Digest Dis & Nutr Ctr, 3435 Main St,422 BRB, Buffalo, NY 14214 USA.
EM lixinzhu@buffalo.edu; sbake@upa.chob.edu
RI Zhu, Lixin/ACE-1496-2022
OI Zhu, Lixin/0000-0001-7904-1769
FU Peter and Tommy Fund, Inc. (Buffalo, NY); SKI4E Fund
FX This work was supported by a grant from the Peter and Tommy Fund, Inc.
   (Buffalo, NY; to S.S.B.), a grant from the SKI4E Fund (to S.S.B.), and a
   departmental start-up fund (to L.Z.).
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NR 49
TC 1312
Z9 1406
U1 8
U2 257
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0270-9139
EI 1527-3350
J9 HEPATOLOGY
JI Hepatology
PD FEB
PY 2013
VL 57
IS 2
BP 601
EP 609
DI 10.1002/hep.26093
PG 9
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 099TA
UT WOS:000315643400020
PM 23055155
OA Bronze
DA 2025-06-11
ER

PT J
AU Kim, JH
   Hong, YC
AF Kim, Jin Hee
   Hong, Yun-Chul
TI GSTM1, GSTT-1, and GSTP1 Polymorphisms and
   Associations between Air Pollutants and Markers of Insulin Resistance in
   Elderly Koreans
SO ENVIRONMENTAL HEALTH PERSPECTIVES
LA English
DT Article
DE air pollution; elderly; genetic polymorphism; insulin resistance
ID HEART-RATE-VARIABILITY; OXIDATIVE STRESS; AIRBORNE PARTICLES; METABOLIC
   SYNDROME; MISSING DATA; POLLUTION; INFLAMMATION; MORTALITY; EXPOSURE;
   OBESITY
AB BACKGROUND: Previous studies have suggested that diabetes mellitus (DM) is an outcome of exposure to air pollution, and metabolic detoxification genes affect air pollution related outcomes.
   OBJECTIVES: We evaluated associations between air pollutants and markers of insulin resistance (IR), an underlying mechanism of type 2 DM, and effect modification by GSTM1, GSTT1, and GSTP1 genotypes among elderly participants in die Korean Elderly Environmental Panel (KEEP) study.
   METHODS: We recruited 560 people >= 60 years of age and obtained blood samples from them up to three times between 2008 and 2010. For air pollution exposure, we used ambient air pollutant [i.e., particulate matter <= 10 mu m in diameter (PM10), sulfur dioxide (SO2), ozone (O-3), and nitrogen dioxide (NO2)] monitoring data. We measured levels of fasting glucose and insulin and derived the homeostatic model assessment (HOMA) index to assess IR. Mixed-effect models were used to estimate associations between air pollutants and IR indices on the same day or lagged up to 10 days prior, and effect modification by GSTM1, GSTT1, and GSTP1 genotypes.
   RESULTS: Interquartile range increases in PM10,O-3, and NO2 were significantly associated with IR indices, depending on the lag period. Associations were stronger among participants with a history of DM and among those with GSTM1-null, GSTT1-null, and GSTP1 AG or GG genotypes.
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C1 [Hong, Yun-Chul] Seoul Natl Univ, Coll Med, Dept Prevent Med, Seoul 110799, South Korea.
   [Kim, Jin Hee; Hong, Yun-Chul] Seoul Natl Univ, Med Res Ctr, Inst Environm Med, Seoul 110799, South Korea.
C3 Seoul National University (SNU); Seoul National University (SNU)
RP Hong, YC (corresponding author), Seoul Natl Univ, Coll Med, Dept Prevent Med, Room 506,103 Daehakro, Seoul 110799, South Korea.
EM ychong1@snu.ac.kr
RI kim, jm/O-5935-2014; Hong, Yun-Chul/J-5725-2012
OI KIM, JIN HEE/0000-0003-1204-7079
FU Ministry of Environment; National Research Foundation of Korea; Ministry
   of Education, Science and Technology, Republic of Korea [2010-0002707]
FX This study was supported by the Susceptible Population Research Program
   (2008-2010) of the Ministry of Environment and the Basic Science
   Research Program through the National Research Foundation of Korea
   funded by the Ministry of Education, Science and Technology
   (2010-0002707), Republic of Korea.
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NR 35
TC 94
Z9 104
U1 0
U2 35
PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE
PI RES TRIANGLE PK
PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233,
   RES TRIANGLE PK, NC 27709-2233 USA
SN 0091-6765
J9 ENVIRON HEALTH PERSP
JI Environ. Health Perspect.
PD OCT
PY 2012
VL 120
IS 10
BP 1378
EP 1384
DI 10.1289/ehp.1104406
PG 7
WC Environmental Sciences; Public, Environmental & Occupational Health;
   Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health; Toxicology
GA 018US
UT WOS:000309692600018
PM 22732554
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Nourieh, Z
   Keshavarz, SA
   Attar, MJH
   Azadbakht, L
AF Nourieh, Zeinab
   Keshavarz, Seyed Ali
   Attar, Mohammad Javad Hosseinzadeh
   Azadbakht, Leila
TI Effects of soy milk consumption on inflammatory markers and lipid
   profiles among non-menopausal overweight and obese female adults
SO JOURNAL OF RESEARCH IN MEDICAL SCIENCES
LA English
DT Article
DE Soy Milk; Inflammation; Obese; Overweight; Females
ID C-REACTIVE PROTEIN; HEALTHY POSTMENOPAUSAL WOMEN; KAPPA-B ACTIVATION;
   METABOLIC SYNDROME; ENDOTHELIAL FUNCTION; SOYMILK SUPPLEMENTATION;
   CARDIOVASCULAR-DISEASE; OXIDATIVE STRESS; TEHRANIAN ADULTS;
   HIGH-ISOFLAVONE
AB BACKGROUND: Few studies have evaluated the effects of soy milk replacement in the diet on inflammatory markers among non-menopausal overweight and obese female adults. We evaluated the effects of soy milk compared to cow's milk on inflammation and lipid profiles among non-menopausal overweight and obese female adults. METHODS: This cross-over randomized clinical trial was conducted on 24 overweight or obese women. There were two 4-week trial periods (soy milk period and cow's milk period). In the soy milk period, only one glass of soy milk (240 cc) was replaced instead of one glass of cow's milk (240 cc). RESULTS: Fat contents in soy milk and cow's milk were 1 g per 100 ml and 1.5 g per 100 ml, respectively. Serum low density lipoprotein (LDL) level reduced significantly following soy milk period (mean percent change in soy milk period vs. cow's milk period: -11.22 +/- 3.85% vs. -1.18 +/- 2.82%; p = 0.01). Inflammatory factors and other lipid profiles did not change significantly after the soy milk period compared to the cow's milk period. In addition, soy milk could not reduce the weight of non-menopausal overweight and obese female adults. CONCLUSION: Soy milk replacement had beneficial effects on LDL levels in a short term trial among overweight and obese women. However, it had no significant effects on inflammatory markers and other lipid profiles among these non-menopausal overweight and obese adults.
C1 [Azadbakht, Leila] Isfahan Univ Med Sci, Sch Nutr & Food Sci, Dept Community Nutr, Food Secur Res Ctr, Esfahan, Iran.
   [Nourieh, Zeinab; Keshavarz, Seyed Ali; Attar, Mohammad Javad Hosseinzadeh] Univ Tehran Med Sci, Sch Publ Hlth, Dept Biochem & Nutr, Tehran, Iran.
C3 Isfahan University of Medical Sciences; Tehran University of Medical
   Sciences
RP Azadbakht, L (corresponding author), Isfahan Univ Med Sci, Sch Nutr & Food Sci, Dept Community Nutr, Food Secur Res Ctr, Esfahan, Iran.
EM azadbakht@hlth.mui.ac.ir
RI keshavarz, Seyed/AAD-3261-2019; Hosseinzadeh-Attar,
   Mohammad/E-9358-2018; Azadbakht, Leila/N-2801-2018
OI Azadbakht, Leila/0000-0002-5955-6818; Keshavarz, Seyyed
   Ali/0000-0002-5173-7665
FU Tehran University of Medical Sciences (Iran); Food Security Research
   Center, Isfahan University of Medical Sciences (Iran) [289249]; Tehran
   University of Medical Sciences and Food Security Research Center
FX This research was approved and supported by Tehran University of Medical
   Sciences and Food Security Research Center, Isfahan University of
   Medical Sciences (both in Iran) (project No. 289249). It was also
   registered in the Iranian Registry of Clinical Trials
   (IRCT201107052839N3). The writers appreciate the cooperation of the
   Cardiovascular Research Center, Isfahan University of Medical Sciences
   for providing facilities to do the biochemical experiments. We also
   thank all participants for their cooperation.
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NR 54
TC 8
Z9 8
U1 0
U2 11
PU ISFAHAN UNIV MED SCIENCES
PI ISFAHAN
PA HEZARJERIB AVE, PO BOX 81745-319, ISFAHAN, 00000, IRAN
SN 1735-1995
J9 J RES MED SCI
JI J. Res. Med. Sci.
PD MAR
PY 2012
VL 17
SI SI
BP S65
EP S72
PN 1
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 997SP
UT WOS:000308186700012
DA 2025-06-11
ER

PT J
AU Gulati, D
   Grewal, AS
   Saini, B
AF Gulati, Diksha
   Grewal, Ajmer Singh
   Saini, Balraj
TI Bioactive Phytochemicals: Unlocking the Promise of Natural Remedies for
   Diabetes Mellitus
SO CURRENT PHARMACEUTICAL BIOTECHNOLOGY
LA English
DT Review; Early Access
DE Diabetes mellitus; anti-diabetic agents; herbal drugs; pancreatic
   beta-cells; insulin; phytoconstituents; natural remedies
ID EUDESMANE-TYPE SESQUITERPENE; INDUCED INSULIN-RESISTANCE; FASTING
   BLOOD-GLUCOSE; ALOE-VERA GEL; MEDICINAL-PLANTS; OXIDATIVE STRESS;
   DOUBLE-BLIND; GLYCEMIC CONTROL; AMELIORATES HYPERGLYCEMIA; POLYHERBAL
   FORMULATION
AB Background Metabolic syndrome encompasses conditions such as diabetes mellitus (DM), which has become increasingly prevalent. Chemically synthesized medications are commonly used to mitigate the effects of DM and its complications; however, these often result in undesirable side effects, including weight gain, digestive issues, and heart failure.Objective This review highlights the therapeutic potential of bioactive compounds and anti-diabetic plants that possess proven anti-diabetic properties. Focusing on phytomedicines also explores their possible mechanisms of action and positions this work relative to current reviews in the field.Methods A comprehensive literature analysis was conducted, emphasizing the therapeutic potential of bioactive compounds in anti-diabetic plants. Databases such as PubMed, Scopus, and Google Scholar were thoroughly searched to identify studies investigating the anti-diabetic properties and mechanisms of action of plant-derived bioactive compounds. Inclusion criteria focused on studies evaluating the pharmacological effects of herbal medicines, plant extracts, and isolated bioactive compounds on diabetes management.Results Therapeutic plants, as sources of anti-diabetic compounds, offer significant advantages. They are affordable, exhibit minimal or no adverse effects, and do not necessitate strict dietary restrictions or intense exercise regimens. The integrated insights underscore the potential of phytomedicines to address limitations in current diabetes management strategies.Conclusion The unique focus on phytomedicines positions this review as a valuable resource for researchers and clinicians. Detailing mechanisms and evidence supporting the efficacy of these compounds, guides the development of innovative strategies for identifying and utilizing bioactive compounds in effective diabetes management.
C1 [Gulati, Diksha; Saini, Balraj] Chitkara Univ, Chitkara Coll Pharm, Rajpura, Punjab, India.
   [Gulati, Diksha; Grewal, Ajmer Singh] Guru Gobind Singh Coll Pharm, Yamunanagar, Haryana, India.
C3 Chitkara University, Punjab
RP Saini, B (corresponding author), Chitkara Univ, Chitkara Coll Pharm, Rajpura, Punjab, India.; Grewal, AS (corresponding author), Guru Gobind Singh Coll Pharm, Yamunanagar, Haryana, India.
EM balraj.saini@chitkara.edu.in; ajmergrewal2007@gmail.com
RI Saini, Dr Balraj/HKE-0652-2023; Grewal, Ajmer/J-1171-2019
OI Grewal, Ajmer Singh/0000-0002-2418-9616
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PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1389-2010
EI 1873-4316
J9 CURR PHARM BIOTECHNO
JI Curr. Pharm. Biotechnol.
PD 2025 APR 3
PY 2025
DI 10.2174/0113892010371753250324150813
EA APR 2025
PG 33
WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
GA 2DR5A
UT WOS:001480185800001
PM 40183261
DA 2025-06-11
ER

PT J
AU Khabiri, R
   Jahangiry, L
   Abbasian, M
   Majidi, F
   Farhangi, MA
   Sadeghi-bazargani, H
   Ponnet, K
AF Khabiri, Roghayeh
   Jahangiry, Leila
   Abbasian, Mehdi
   Majidi, Fatollah
   Farhangi, Mahdieh Abbasalizad
   Sadeghi-bazargani, Homayoun
   Ponnet, Koen
TI Spiritually Based Interventions for High Blood Pressure: A Systematic
   Review and Meta-analysis
SO JOURNAL OF RELIGION & HEALTH
LA English
DT Article
DE Blood pressure; Meditation; Yoga; Spiritually based intervention
ID RANDOMIZED CONTROLLED-TRIAL; TRANSCENDENTAL-MEDITATION; STRESS
   REDUCTION; METABOLIC SYNDROME; HYPERTENSION; PROGRAM; HEALTH; RISK;
   MINDFULNESS; DISEASE
AB This systematic review and meta-analysis aimed to evaluate the effectiveness of spiritually based interventions on blood pressure (BP) among adults. A systematic search was performed using the PubMed, Scopus, and Cochrane databases to identify studies evaluating spiritual interventions, including meditation, transcendental meditation, mindfulness meditation, and yoga, for high BP among adults up to January 1, 2022. The inclusion criteria were (a) randomized controlled trials (RCTs), (b) studies in English or Persian, (c) studies conducted among adults (>= 18 years), and (d) studies reporting systolic or diastolic BP. Given the high heterogeneity of these studies, a random effect model was used to calculate the effect sizes for the RCTs. In total, the systematic review included 24 studies and the meta-analysis included 23 studies. As some of studies reported two or more outcome measurements, separate estimates of each outcome were extracted for that study (24 datasets). Fifteen trials reported the mean (SD) systolic blood pressure (SBP), and 13 trials reported the mean (SD) diastolic blood pressure (DBP). In addition, 13 studies reported means (SDs) and six trials reported mean changes in DBP. A significant decrease was found in systolic BP following intervention ((WMD (weighted mean difference) = - 7.63 [- 9.61 to - 5.65; P < 0.001]). We observed significant heterogeneity among the studies (I-2 = 96.9; P < 0.001). A significant decrease was observed in DBP following the interventions (WMD = - 4.75 [- 6.45 to - 3.05; P < 0.001]). Spiritually based interventions including meditation and yoga had beneficial effects in reducing both SBP and DBP. Reducing BP can be expected to reduce the risk of cardiovascular diseases.
C1 [Khabiri, Roghayeh] Tabriz Univ Med Sci, Tabriz Hlth Serv Management Res Ctr, Tabriz, Iran.
   [Jahangiry, Leila] Tabriz Univ Med Sci, Sch Publ Hlth, Hlth Educ & Hlth Promot Dept, Tabriz, Iran.
   [Jahangiry, Leila; Majidi, Fatollah] Tabriz Univ Med Sci, Hlth Management & Safety Promot Res Inst, Med Educ Res Ctr, Tabriz, Iran.
   [Abbasian, Mehdi] Tabriz Univ Med Sci, Student Res Comm, Tabriz, Iran.
   [Abbasian, Mehdi] Tabriz Univ Med Sci, Fac Hlth Sci, Dept Geriatr Hlth, Tabriz, Iran.
   [Farhangi, Mahdieh Abbasalizad] Tabriz Univ Med Sci, Fac Nutr, Dept Community Nutr, Tabriz, Iran.
   [Sadeghi-bazargani, Homayoun] Tabriz Univ Med Sci, Rd Traff Injury Res Ctr, Tabriz, Iran.
   [Ponnet, Koen] Imec Mict Ghent Univ, Fac Social Sci, Ghent, Belgium.
C3 Tabriz University of Medical Science; Tabriz University of Medical
   Science; Tabriz University of Medical Science; Tabriz University of
   Medical Science; Tabriz University of Medical Science; Tabriz University
   of Medical Science; Tabriz University of Medical Science; Ghent
   University
RP Jahangiry, L (corresponding author), Tabriz Univ Med Sci, Sch Publ Hlth, Hlth Educ & Hlth Promot Dept, Tabriz, Iran.; Jahangiry, L (corresponding author), Tabriz Univ Med Sci, Hlth Management & Safety Promot Res Inst, Med Educ Res Ctr, Tabriz, Iran.
EM jahangiryleila@gmail.com
RI Ponnet, Koen/K-9389-2017; Sadeghi-Bazargani, Homayoun/M-5522-2017;
   Farhangi, Mahdieh/AAC-6758-2019; Abbasian, Mehdi/JZD-5888-2024; Khabiri,
   Roghayeh/H-6287-2018; Jahangiry, Leila/F-9880-2017
OI Jahangiry, Leila/0000-0002-0491-5764; Abbasian,
   Mehdi/0000-0001-6145-2439
FU Tabriz University of Medical Sciences, Tabriz, Iran
FX We acknowledge the contributions of Tabriz University of Medical
   Sciences, Tabriz, Iran, for providing facilities to the study.
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PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0022-4197
EI 1573-6571
J9 J RELIG HEALTH
JI J. Relig. Health
PD OCT
PY 2024
VL 63
IS 5
SI SI
BP 3474
EP 3500
DI 10.1007/s10943-024-02034-3
EA APR 2024
PG 27
WC Public, Environmental & Occupational Health; Religion
WE Social Science Citation Index (SSCI); Arts &amp; Humanities Citation Index (A&amp;HCI)
SC Public, Environmental & Occupational Health; Religion
GA K4I8I
UT WOS:001195676800002
PM 38565834
DA 2025-06-11
ER

PT J
AU Oliveira, VM
   Silveira, LR
   Bunnel, KT
   Domingueti, CP
   Baldoni, AO
   Baldoni, NR
   do Couto, RO
AF Oliveira, Virginia Moura
   Silveira, Leticia Rafaela
   Bunnel, Kitete Tunda
   Domingueti, Caroline Pereira
   Baldoni, Andre Oliveira
   Baldoni, Nayara Ragi
   do Couto, Rene Oliveira
TI Rosemary (Rosmarinus officinalis L.) improves biochemical
   outcomes in diabetes mellitus: a systematic review and meta-analysis of
   animal studies
SO ADVANCES IN TRADITIONAL MEDICINE
LA English
DT Review
DE Diabetes Complications; Hypoglycemic Agents; Insulin; Medicinal Plant;
   Metabolic Syndrome; Nutraceuticals
ID OXIDATIVE STRESS; EXTRACT; MODELS; DIAGNOSIS; TRENDS
AB We report on the systematic review and meta-analysis concerning the efficacy of R. officinalis in treating diabetes mellitus (DM) in animals. This study followed the PRISMA guideline and the protocol was registered in PROSPERO (CRD42021250556). The research was duplicated in the PubMed, Scopus, ScienceDirect, Web of Science, and Virtual Health Library (VHL) databases until December 31st, 2022. No restrictions have been set for language publication. Twenty-three (23) experimental studies of type-1 diabetes mellitus (T1DM) met the eligibility criteria and were included in the qualitative analysis, whereas eighteen (18) underwent a meta-analysis. The R. officinalis derivatives significantly decreased fasting plasma glucose (MD: -120.84 [95% CI; -157.09, -84.59]); increased insulin release (MD; +3.73 [95% CI; +3.17, +4.29]); dwindled blood urea nitrogen (MD: -24.84 [95% CI; -34.78, -14.90]) and creatinine (MD: -0.40 [95% CI; -0.74, -0.06]) levels; and ameliorated liver function or repaired liver damage by decreasing ALT (MD: -36.42; [95% CI; -55.69, -17.14]) and AST (MD: -24.05 [95% CI; -37.84, -10.27]) enzyme levels compared to vehicle control group. Moreover, R. officinalis derivatives improved the lipid profile of diabetic animals by reducing LDL-c levels (MD: -11.74 [95% CI; -21.27, -2.21]). R. officinalis is a nutraceutical that may help in the management of T1DM and its complications. However, some gaps need to be taken into account for this evidence. Greater attention is needed for an analytical standardization of Rosemary extracts besides the demand for high-quality clinical studies dealing with the efficacy of this phytomedicine.
C1 [Oliveira, Virginia Moura; Silveira, Leticia Rafaela; Bunnel, Kitete Tunda; Domingueti, Caroline Pereira; Baldoni, Andre Oliveira; do Couto, Rene Oliveira] Univ Fed Sao Joao Del Rei UFSJ, Campus Ctr Oeste Dona Lindu CCO,R Sebastiao Goncal, BR-35501296 Divinopolis, MG, Brazil.
   [Baldoni, Nayara Ragi] Univ Itauna UIT, Rodovia MG 431 Km 45, s-n, BR-35680142 Itauna, MG, Brazil.
C3 Universidade Federal de Sao Joao del-Rei; Universidade de Itauna
RP do Couto, RO (corresponding author), Univ Fed Sao Joao Del Rei UFSJ, Campus Ctr Oeste Dona Lindu CCO,R Sebastiao Goncal, BR-35501296 Divinopolis, MG, Brazil.
EM rocouto@ufsj.edu.br
RI Domingueti, Caroline/JCE-9314-2023; Baldoni, Nayara/AAR-4372-2021; AO
   BALDONI, AO/B-3219-2016; Couto, Rene/C-1419-2012
OI Couto, Rene/0000-0002-3748-3427; Oliveira Baldoni,
   Andre/0000-0001-6379-0415
FU Fundao de Amparo Pesquisa do Estado de Minas Gerais
FX We appreciate Dr. Zbys Fedorowicz (Veritas Health Sciences Consultancy)
   and Gesner Francisco Xavier Junior (librarian of the Medical School -
   Federal University of Minas Gerais) for their valuable support with the
   review protocol.
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NR 91
TC 1
Z9 1
U1 2
U2 3
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 2662-4052
EI 2662-4060
J9 ADV TRADIT MED
JI Adv. Tradit. Med.
PD MAR
PY 2025
VL 25
IS 1
BP 1
EP 26
DI 10.1007/s13596-024-00742-5
EA FEB 2024
PG 26
WC Pharmacology & Pharmacy
WE Emerging Sources Citation Index (ESCI)
SC Pharmacology & Pharmacy
GA X8H4D
UT WOS:001171642800001
DA 2025-06-11
ER

PT J
AU Finicelli, M
   Di Salle, A
   Galderisi, U
   Peluso, G
AF Finicelli, Mauro
   Di Salle, Anna
   Galderisi, Umberto
   Peluso, Gianfranco
TI The Mediterranean Diet: An Update of the Clinical Trials
SO NUTRIENTS
LA English
DT Review
DE Mediterranean Diet; clinical trials; inflammation; oxidative stress;
   cardiovascular disease; metabolic diseases; cancer; diabetes
ID CORONARY-HEART-DISEASE; METABOLIC SYNDROME; CARDIOVASCULAR-DISEASE; FOOD
   GROUPS; OLIVE OIL; RISK; CANCER; METAANALYSIS; IMPACT; MACROPHAGES
AB The Mediterranean Diet (MedDiet) is a term used to identify a dietary pattern originating from the unique multi-millennial interplay between natural food resources and the eating practices of people living in the Mediterranean basin. Scientific evidence has described the healthy properties of the MedDiet and its beneficial role in several pathological conditions. Nevertheless, current socio-economic trends have moved people away from this healthy lifestyle. Thus, clinical and biological evidence supporting the benefits of the MedDiet is needed to overcome these limitations. Clinical nutrition research examines the effects of dietary interventions on biological or health-related outcomes in a determined study population. The evidence produced by these studies is useful for dietary guidance and public health messaging. We provided an update of the clinical trials registered on the database clinicaltrials.gov evaluating the effects of the MedDiet on health and specific diseases. Our findings revealed an increased number of clinical trials in the last decade and found that most disease-related studies focused on cardiovascular diseases, metabolic diseases, and cancer. The majority of MedDiet's beneficial effects could be primarily related to its anti-inflammatory and anti-oxidant properties as well as the effectiveness of this dietary pattern in controlling waist circumference and obesity. Moreover, strict and long-lasting adherence to the MedDiet as well as the beneficial effects of specific components (e.g., olive oil or its polyphenols) seem to emerge as useful insights for interventional improvements. These findings present further insights into the MedDiet's resources and how it could strengthen overall public health.
C1 [Finicelli, Mauro; Di Salle, Anna; Peluso, Gianfranco] Natl Res Council Italy CNR, Res Inst Terr Ecosyst IRET, Via Pietro Castellino 111, I-80131 Naples, Italy.
   [Galderisi, Umberto] Univ Campania Luigi Vanvitelli, Dept Expt Med, Via Santa Maria di Costantinopoli 16, I-80138 Naples, Italy.
   [Peluso, Gianfranco] St Camillus Int Univ Hlth Sci, Fac Med & Surg, Via St Alessandro 8, I-00131 Rome, Italy.
C3 Consiglio Nazionale delle Ricerche (CNR); Istituto di Ricerca sugli
   Ecosistemi Terrestri (IRET); Universita della Campania Vanvitelli
RP Finicelli, M; Peluso, G (corresponding author), Natl Res Council Italy CNR, Res Inst Terr Ecosyst IRET, Via Pietro Castellino 111, I-80131 Naples, Italy.; Peluso, G (corresponding author), St Camillus Int Univ Hlth Sci, Fac Med & Surg, Via St Alessandro 8, I-00131 Rome, Italy.
EM mauro.finicelli@cnr.it; anna.disalle@cnr.it;
   umberto.galderisi@unicampania.it; gianfranco.peluso@unicamillus.org
RI Finicelli, Mauro/ABC-1392-2020; Di Salle, A/AAF-5416-2019
OI Finicelli, Mauro/0000-0003-2289-0916; Di Salle,
   Anna/0000-0001-6763-3636; GALDERISI, Umberto/0000-0003-0909-7403
FU PON I&C 2014-2020 MiSE, project title: "Micro-nanodispositivi veicolanti
   polifenoli isolati da scarti della filiera olivicola come nuovi
   integratori alimentari-MicroPoli; POR Campania FESR 2014-2020: "Sviluppo
   di nanotecnologie Orientate alla Rigenerazione e Ricostruzione
   tissutale, Implantologia e Sensoristica in Odontoiatria/oculistica
   (SORRISO)"; PSR Campania 2014-2020, project title: "Identificazione
   delle componenti salutistiche della filiera olivicola campana" acronimo
   "OLIVEHEALTH"
FX This study was funded by PON I&C 2014-2020 MiSE, project title:
   "Micro-nanodispositivi veicolanti polifenoli isolati da scarti della
   filiera olivicola come nuovi integratori alimentari-MicroPoli; POR
   Campania FESR 2014-2020: "Sviluppo di nanotecnologie Orientate alla
   Rigenerazione e Ricostruzione tissutale, Implantologia e Sensoristica in
   Odontoiatria/oculistica (SORRISO)"; PSR Campania 2014-2020, project
   title: "Identificazione delle componenti salutistiche della filiera
   olivicola campana" acronimo "OLIVEHEALTH".
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NR 107
TC 92
Z9 94
U1 10
U2 54
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JUL
PY 2022
VL 14
IS 14
AR 2956
DI 10.3390/nu14142956
PG 21
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 3K0EY
UT WOS:000833760800001
PM 35889911
OA Green Published, gold
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Sharma, I
   Liao, YJ
   Zheng, XP
   Kanwar, YS
AF Sharma, Isha
   Liao, Yingjun
   Zheng, Xiaoping
   Kanwar, Yashpal S.
TI New Pandemic: Obesity and Associated Nephropathy
SO FRONTIERS IN MEDICINE
LA English
DT Review
DE obesity; kidney; hyperlipidemia; inflammation; oxidant stress; fibrosis
ID CHRONIC KIDNEY-DISEASE; HIGH-DENSITY-LIPOPROTEIN; X-RECEPTOR-ALPHA;
   BODY-MASS INDEX; ANGIOTENSIN-ALDOSTERONE SYSTEM; SERUM PARAOXONASE
   ACTIVITY; RENAL LIPID-ACCUMULATION; METABOLIC SYNDROME; BARIATRIC
   SURGERY; WEIGHT-LOSS
AB Incidence of obesity related renal disorders have increased 10-folds in recent years. One of the consequences of obesity is an increased glomerular filtration rate (GFR) that leads to the enlargement of the renal glomerulus, i.e., glomerulomegaly. This heightened hyper-filtration in the setting of type 2 diabetes irreparably damages the kidney and leads to progression of end stage renal disease (ESRD). The patients suffering from type 2 diabetes have progressive proteinuria, and eventually one third of them develop chronic kidney disease (CKD) and ESRD. For ameliorating the progression of CKD, inhibitors of renin angiotensin aldosterone system (RAAS) seemed to be effective, but on a short-term basis only. Long term and stable treatment strategies like weight loss via restricted or hypo-caloric diet or bariatric surgery have yielded better promising results in terms of amelioration of proteinuria and maintenance of normal GFR. Body mass index (BMI) is considered as a traditional marker for the onset of obesity, but apparently, it is not a reliable indicator, and thus there is a need for more precise evaluation of regional fat distribution and amount of muscle mass. With respect to the pathogenesis, recent investigations have suggested perturbation in fatty acid and cholesterol metabolism as the critical mediators in ectopic renal lipid accumulation associated with inflammation, increased generation of ROS, RAAS activation and consequential tubulo-interstitial injury. This review summarizes the renewed approaches for the obesity assessment and evaluation of the pathogenesis of CKD, altered renal hemodynamics and potential therapeutic targets.
C1 [Sharma, Isha; Liao, Yingjun; Zheng, Xiaoping; Kanwar, Yashpal S.] Northwestern Univ, Dept Pathol, Chicago, IL 60611 USA.
   [Sharma, Isha; Liao, Yingjun; Zheng, Xiaoping; Kanwar, Yashpal S.] Northwestern Univ, Dept Med, Chicago, IL 60611 USA.
   [Liao, Yingjun] Cent South Univ, Xiangya Hosp 2, Dept Nephrol, Changsha, Peoples R China.
   [Zheng, Xiaoping] Cent South Univ, Xiangya Hosp 3, Dept Urol, Changsha, Peoples R China.
C3 Northwestern University; Northwestern University; Central South
   University; Central South University
RP Sharma, I; Kanwar, YS (corresponding author), Northwestern Univ, Dept Pathol, Chicago, IL 60611 USA.; Sharma, I; Kanwar, YS (corresponding author), Northwestern Univ, Dept Med, Chicago, IL 60611 USA.
EM isha.sharma1@northwestern.edu; y-kanwar@northwestern.edu
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NR 154
TC 31
Z9 35
U1 0
U2 6
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 2296-858X
J9 FRONT MED-LAUSANNE
JI Front. Med.
PD JUN 29
PY 2021
VL 8
AR 673556
DI 10.3389/fmed.2021.673556
PG 15
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA TH8OL
UT WOS:000672342900001
PM 34268323
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Gosal, H
   Kaur, H
   Ngassa, HC
   Elmenawi, KA
   Anil, V
   Mohammed, L
AF Gosal, Harpreet
   Kaur, Harsimran
   Ngassa, Hyginus Chakwop
   Elmenawi, Khaled A.
   Anil, Vishwanath
   Mohammed, Lubna
TI The Significance of the Mediterranean Diet in the Management of
   Non-Alcoholic Fatty Liver Disease: A Systematic Review
SO CUREUS JOURNAL OF MEDICAL SCIENCE
LA English
DT Review
DE nonalcoholic fatty liver disease (nafld); mediterranean diet; nash and
   steatosis; olive oil; plant-based diet
ID PREVENTION; RECOMMENDATIONS; SODIUM; NAFLD; OIL
AB Non-alcoholic fatty liver disease (NAFLD) is the accumulation of intrahepatic fat occurring in the absence of alcohol abuse. The fatty changes in the liver are often the beginning of sequelae of complications, potentially causing steatohepatitis, liver cirrhosis, and hepatocellular carcinoma. The Mediterranean diet is not only a way of eating but is considered a lifestyle and primarily consists of a plant-based diet, with olive oil as the primary lipid. In this study, we reviewed the effectiveness of the Mediterranean diet on NAFLD and its efficacy in disease management. This systematic review follows the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocol (PRISMA-P) 2009 guidelines. The PubMed database was used to gather articles, using the following terms individually and in combination, "Mediterranean diet," "non-alcoholic fatty liver disease," "insulin resistance," "metabolic syndrome," "omega-3-fatty acids." A quality appraisal was completed to include 14 articles in this systematic review. The studies discuss the correlation between the Mediterranean diet and its role in preventing and treating NAFLD. Olive oil is the major monounsaturated fatty acid, whereas nuts, seeds, and fish consist largely of polyunsaturated fatty acids, both of which are essential components of the Mediterranean diet. The plant-based diet, having sufficient amounts of vegetables, legumes, and fruits, provides its anti-oxidant and anti-inflammatory effects, playing a fundamental role in preventing oxidative stress damage. Olive oil polyphenols increase apoptosis and cell cycle arrest. They also decrease proliferation and angiogenesis, all of which prevent neoplasia. Adapting the Mediterranean lifestyle has shown promising effects in NAFLD, reducing overall mortality and morbidity.
C1 [Gosal, Harpreet; Anil, Vishwanath; Mohammed, Lubna] Calif Inst Behav Neurosci & Psychol, Internal Med, Fairfield, CA 94534 USA.
   [Gosal, Harpreet] Govt Med Coll, Internal Med, Amritsar, Punjab, India.
   [Kaur, Harsimran] Calif Inst Behav Neurosci & Psychol, Med, Fairfield, CA USA.
   [Ngassa, Hyginus Chakwop] Univ Brescia, Fac Med & Surg, Gastrointestinal Surg, Brescia, Italy.
   [Ngassa, Hyginus Chakwop] Calif Inst Behav Neurosci & Psychol, Surg, Fairfield, CA USA.
   [Elmenawi, Khaled A.] Cairo Univ, Surg, Cairo, Egypt.
   [Elmenawi, Khaled A.] Calif Inst Behav Neurosci & Psychol, Internal Med Surg, Fairfield, CA USA.
C3 University of Brescia; Egyptian Knowledge Bank (EKB); Cairo University
RP Gosal, H (corresponding author), Calif Inst Behav Neurosci & Psychol, Internal Med, Fairfield, CA 94534 USA.; Gosal, H (corresponding author), Govt Med Coll, Internal Med, Amritsar, Punjab, India.
EM gosalharpreet15@gmail.com
RI Mohammed, Lubna/GWC-6096-2022
OI Elmenawi, Khaled Abdelmoneim/0000-0003-1801-960X; Mohammed,
   Lubna/0000-0002-1803-6867
CR Abenavoli L, 2019, INT J ENV RES PUB HE, V16, DOI 10.3390/ijerph16173011
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NR 25
TC 9
Z9 9
U1 1
U2 13
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
EI 2168-8184
J9 CUREUS J MED SCIENCE
JI Cureus J Med Sci
PD JUN 13
PY 2021
VL 13
IS 6
AR e15618
DI 10.7759/cureus.15618
PG 9
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA SR7EK
UT WOS:000661204300002
PM 34277236
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Irshad, N
   Khan, AU
   Shah, FA
   Nadeem, H
   Ashraf, Z
   Tipu, MK
   Li, SP
AF Irshad, Nadeem
   Khan, Arif-ullah
   Shah, Fawad Ali
   Nadeem, Humaira
   Ashraf, Zaman
   Tipu, Muhammad Khalid
   Li, Shupeng
TI Antihyperlipidemic effect of selected pyrimidine derivatives mediated
   through multiple pathways
SO FUNDAMENTAL & CLINICAL PHARMACOLOGY
LA English
DT Article
DE pyrimidines; computational pharmacology; antihyperlipidemic;
   hepatoprotective; antioxidant; anti&#8208; inflammatory
ID OXIDATIVE STRESS; METABOLIC SYNDROME; LIVER; OBESITY; ACID;
   POLYSACCHARIDES; CHOLESTEROL
AB Hyperlipidemia is worth-mentioning risk factor in quickly expanding atherosclerosis, myocardial infarction, and stroke. This study attempted to determine effectiveness of selected pyrimidine derivatives: 5-(3-Hydroxybenzylidene)-2, 4, 6(1H, 3H, 5H)-pyrimidinetrione (SR-5), 5-(4-Hydroxybenzylidene)-2, 4, 6(1H, 3H, 5H)-pyrimidinetrione (SR-8), 5-(3-Chlorobenzylidene)-2, 4, 6(1H, 3H, 5H)-pyrimidinetrione (SR-9), and 5-(4-Chlorobenzylidene)-2, 4, 6(1H, 3H, 5H)-pyrimidinetrione (SR-10) against hyperlipidemia. In silico results revealed that SR-5, SR-8, SR-9, and SR-10 exhibited high affinity with 3-hydroxy-3-methylglutaryl coenzyme A (HMGCoA) possessing binding energy values of -8.2, -8.4, -8.6, and -9.5 Kcal/mol, respectively, and moderate (<-8 Kcal/mol) against other selected targets. In vivo findings showed that test drugs (25 and 50 mg/Kg) significantly decreased HFD rat total cholesterol, triglycerides, low-density lipoprotein, very-low-density lipoprotein, atherogenic index, coronary risk index, alkaline phosphatase, aspartate transaminase, alanine transaminase, and bilirubin and increased high-density lipoprotein (p < 0.05, p < 0.01, p < 0.001 vs HFD group). In animal liver tissues, SR-5, SR-8, SR-9, and SR-10 inhibited HMGCoA reductase enzyme, enhanced glutathione-s-transferase, reduced glutathione, catalase levels, improved cellular architecture in histopathological examination, and decreased expression of inflammatory markers: cyclo-oxygenase 2, tumor necrosis factor alpha, phosphorylated c-Jun N-terminal kinase, and phosphorylated-nuclear factor kappa B, evidenced in immunohistochemistry and enzyme-linked immunosorbent assay molecular investigations. This study indicates that SR-5, SR-8, SR-9, and SR-10 exhibit antihyperlipidemic action, mediated possibly through HMGCoA inhibition, hepatoprotection, antioxidant, and anti-inflammatory pathways.
C1 [Irshad, Nadeem; Khan, Arif-ullah; Shah, Fawad Ali; Nadeem, Humaira] Riphah Int Univ, Riphah Inst Pharmaceut Sci, Islamabad, Pakistan.
   [Irshad, Nadeem; Tipu, Muhammad Khalid] Quaid I Azam Univ, Fac Biol Sci, Dept Pharm, Islamabad, Pakistan.
   [Ashraf, Zaman] Allama Iqbal Open Univ, Dept Chem, Islamabad, Pakistan.
   [Li, Shupeng] Peking Univ, Sch Chem Biol & Biotechnol, Shenzhen Grad Sch, State Key Lab Oncogen, Shenzhen, Peoples R China.
C3 Quaid I Azam University; Peking University
RP Khan, AU (corresponding author), Riphah Int Univ, Riphah Inst Pharmaceut Sci, Islamabad, Pakistan.; Li, SP (corresponding author), Peking Univ, Sch Chem Biol & Biotechnol, Shenzhen Grad Sch, State Key Lab Oncogen, Shenzhen, Peoples R China.
EM arif.ullah@riphah.edu.pk; lisp@pkusz.edu.cn
RI ashraf, zaman/AAH-2147-2021; Dong, Mingxin/AFX-0535-2022; Tipu,
   Muhammad/P-1039-2019; khan, Arif/HMV-3165-2023; Shah,
   Fawad/ACP-0339-2022; nadeem, humaira/JPL-4272-2023; Shah, Fawad
   Ali/ABZ-1868-2022
OI nadeem, humaira/0000-0002-0169-0811; ashraf, zaman/0000-0002-6620-9080;
   Shah, Fawad Ali/0000-0002-5415-2179
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NR 39
TC 10
Z9 10
U1 0
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0767-3981
EI 1472-8206
J9 FUND CLIN PHARMACOL
JI Fundam. Clin. Pharmacol.
PD DEC
PY 2021
VL 35
IS 6
BP 1119
EP 1132
DI 10.1111/fcp.12682
EA MAY 2021
PG 14
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA WX9HT
UT WOS:000645997600001
PM 33872413
DA 2025-06-11
ER

PT J
AU Whitticar, NB
   Nunemaker, CS
AF Whitticar, Nicholas B.
   Nunemaker, Craig S.
TI Reducing Glucokinase Activity to Enhance Insulin Secretion: A
   Counterintuitive Theory to Preserve Cellular Function and Glucose
   Homeostasis
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Article
DE type 2 diabetes; metabolic syndrome; hyperinsulinemia; beta cell;
   pancreatic islet; insulin; pulsatility; glucokinase
ID PANCREATIC BETA-CELL; PULSATILE INSULIN; OXIDATIVE STRESS;
   GLUCAGON-SECRETION; CATALYTIC-ACTIVITY; CHRONIC EXPOSURE; MOUSE ISLETS;
   RESISTANCE; MECHANISM; HYPERINSULINEMIA
AB Pancreatic beta-cells are the only cells in the body that can synthesize and secrete insulin. Through the process of glucose-stimulated insulin secretion, beta-cells release insulin into circulation, stimulating GLUT4-dependent glucose uptake into peripheral tissue. Insulin is normally secreted in pulses that promote signaling at the liver. Long before type 2 diabetes is diagnosed, beta-cells become oversensitive to glucose, causing impaired pulsatility and overstimulation in fasting levels of glucose. The resulting hypersecretion of insulin can cause poor insulin signaling and clearance at the liver, leading to hyperinsulinemia and insulin resistance. Continued overactivity can eventually lead to beta-cell exhaustion and failure at which point type 2 diabetes begins. To prevent or reverse the negative effects of overstimulation, beta-cell activity can be reduced. Clinical studies have revealed the potential of beta-cell rest to reverse new cases of diabetes, but treatments lack durable benefits. In this perspective, we propose an intervention that reduces overactive glucokinase activity in the beta-cell. Glucokinase is known as the glucose sensor of the beta-cell due to its high control over insulin secretion. Therefore, glycolytic overactivity may be responsible for hyperinsulinemia early in the disease and can be reduced to restore normal stimulus-secretion coupling. We have previously reported that reducing glucokinase activity in prediabetic mouse islets can restore pulsatility and enhance insulin secretion. Building on this counterintuitive finding, we review the importance of pulsatile insulin secretion and highlight how normalizing glucose sensing in the beta cell during prediabetic hyperinsulinemia may restore pulsatility and improve glucose homeostasis.
C1 [Whitticar, Nicholas B.] Ohio Univ, Grad Coll, Translat Biomed Sci Program, Athens, OH 45701 USA.
   [Whitticar, Nicholas B.; Nunemaker, Craig S.] Ohio Univ, Heritage Coll Osteopath Med, Athens, OH 45701 USA.
   [Whitticar, Nicholas B.; Nunemaker, Craig S.] Ohio Univ, Heritage Coll Osteopath Med, Dept Biomed Sci, Athens, OH 45701 USA.
C3 University System of Ohio; Ohio University; University System of Ohio;
   Ohio University; University System of Ohio; Ohio University
RP Nunemaker, CS (corresponding author), Ohio Univ, Heritage Coll Osteopath Med, Athens, OH 45701 USA.; Nunemaker, CS (corresponding author), Ohio Univ, Heritage Coll Osteopath Med, Dept Biomed Sci, Athens, OH 45701 USA.
EM nunemake@ohio.edu
RI Nunemaker, Craig/JVN-6684-2024
OI Whitticar, Nicholas/0009-0004-3542-0272
FU National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
   [R15 DK121247]; Diabetes Institute of Ohio University; Heritage College
   of Osteopathic Medicine
FX This work was funded by R15 DK121247 to CN from the National Institute
   of Diabetes and Digestive and Kidney Diseases (NIDDK), the Diabetes
   Institute of Ohio University, and the Heritage College of Osteopathic
   Medicine.
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NR 130
TC 28
Z9 30
U1 0
U2 8
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD JUN 9
PY 2020
VL 11
AR 378
DI 10.3389/fendo.2020.00378
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA MC6GZ
UT WOS:000543384200001
PM 32582035
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Bergens, O
   Veen, J
   Montiel-Rojas, D
   Edholm, P
   Kadi, F
   Nilsson, A
AF Bergens, Oscar
   Veen, Jort
   Montiel-Rojas, Diego
   Edholm, Peter
   Kadi, Fawzi
   Nilsson, Andreas
TI Impact of healthy diet and physical activity on metabolic health in men
   and women Study Protocol Clinical Trial (SPIRIT Compliant)
SO MEDICINE
LA English
DT Article
DE aging; body composition; exercise; healthy diet; metabolic syndrome;
   systemic inflammation
ID OXIDATIVE STRESS; FRUIT; VEGETABLES; INFLAMMATION; CONSUMPTION; MARKERS;
   PATTERN; RICH
AB Introduction: Healthy dietary patterns and physical activity (PA) represent important lifestyle behaviors with considerable potential to influence on age-related metabolic health. Yet, data on the combined effects of these lifestyle behaviors on metabolic health including low-grade systemic inflammation in aging populations remain scarce. Therefore, this protocol describes a randomized controlled trial aiming to examine the impacts of healthy dietary patterns alone or combined with PA on metabolic health in middle-aged and older men and women. Material and Methods: The ORUDIET study is a 3-arm randomized controlled 16-week trial: Healthy Diet (HD), Healthy diet plus PA (HD-PA), and control (CON). The trial is open label, randomized with allocation concealment, parallel groups with passive controls. Participants without overt disease aged between 55 and 70 years, with BMI below 35, a current intake of a maximum of 1 serving of fruit and vegetable per day, and noncompliance to PA guidelines are eligible for inclusion. Participants in HD are instructed to increase fruit and vegetable intake to 5 servings per day (equivalent to 500 g). Participants in HD-PA receive the same dietary intervention as the HD and are additionally instructed to engage in moderate-to-vigorous physical activities for at least 150 minutes per week. The primary study outcomes are changes in metabolic and inflammatory health biomarkers. Secondary outcomes are changes in body composition and perceived health. Ethics and dissemination: The study protocol has been approved by the ethical review board in Uppsala, Sweden. The results will be published in peer-reviewed journals and disseminated in national and international conferences.
C1 [Bergens, Oscar; Veen, Jort; Montiel-Rojas, Diego; Edholm, Peter; Kadi, Fawzi; Nilsson, Andreas] Orebro Univ, Sch Hlth Sci, S-70182 Orebro, Sweden.
C3 Orebro University
RP Nilsson, A (corresponding author), Orebro Univ, Sch Hlth Sci, S-70182 Orebro, Sweden.
EM andreas.nilsson@oru.se
RI Nilsson, Andreas/LKK-3146-2024; Edholm, Peter/NAZ-5721-2025; MONTIEL
   ROJAS, DIEGO/MFI-7882-2025; Kadi, Fawzi/LDV-8063-2024
OI kadi, fawzi/0000-0002-9831-0896; Edholm, Peter/0000-0002-5401-9255;
   Montiel Rojas, Diego/0000-0003-3268-1544
FU EU HORIZON 2020 Research and Innovation Programme (European Joint
   Programming Initiative "A healthy diet for a healthy life" "JPI HDHL");
   EU HORIZON 2020 Research and Innovation Programme (ERA-NET co-fund
   HDHL-INTIMIC) [727565]; H2020 Societal Challenges Programme [727565]
   Funding Source: H2020 Societal Challenges Programme
FX This research protocol is funded by the EU HORIZON 2020 Research and
   Innovation Programme (European Joint Programming Initiative "A healthy
   diet for a healthy life" "JPI HDHL" and the ERA-NET co-fund
   HDHL-INTIMIC, "GA no. 727565").
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NR 29
TC 1
Z9 3
U1 1
U2 13
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD APR
PY 2020
VL 99
IS 16
AR e19584
DI 10.1097/MD.0000000000019584
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA ME5SF
UT WOS:000544714800010
PM 32311926
OA Green Published
DA 2025-06-11
ER

PT J
AU Otto, L
   Budde, K
   Kastenmüller, G
   Kaul, A
   Völker, U
   Völzke, H
   Adamski, J
   Kühn, JP
   Krumsiek, J
   Artati, A
   Nauck, M
   Friedrich, N
   Pietzner, M
AF Otto, Lerina
   Budde, Kathrin
   Kastenmueller, Gabi
   Kaul, Anne
   Voelker, Uwe
   Voelzke, Henry
   Adamski, Jerzy
   Kuehn, Jens P.
   Krumsiek, Jan
   Artati, Anna
   Nauck, Matthias
   Friedrich, Nele
   Pietzner, Maik
TI Associations between adipose tissue volume and small molecules in plasma
   and urine among asymptomatic subjects from the general population
SO SCIENTIFIC REPORTS
LA English
DT Article
ID VISCERAL FAT; METABOLITE PROFILES; INSULIN-RESISTANCE; BLACK PEPPER;
   AMINO-ACIDS; OBESITY; BLOOD; METABOLOMICS; MORTALITY; PIPERINE
AB Obesity is one of the major risk factor for cardiovascular and metabolic diseases. A disproportional accumulation of fat at visceral (VAT) compared to subcutaneous sites (SAT) has been suspected as a key detrimental event. We used non-targeted metabolomics profiling to reveal metabolic pathways associated with higher VAT or SAT amount among subjects free of metabolic diseases to identify possible contributing metabolic pathways. The study population comprised 491 subjects [mean (standard deviation): age 44.6yrs (13.0), body mass index 25.4kg/m(2) (3.6), 60.1% females] without diabetes, hypertension, dyslipidemia, the metabolic syndrome or impaired renal function. We associated MRI-derived fat amounts with mass spectrometry-derived metabolites in plasma and urine using linear regression models adjusting for major confounders. We tested for sex-specific effects using interactions terms and performed sensitivity analyses for the influence of insulin resistance on the results. VAT and SAT were significantly associated with 155 (101 urine) and 49 (29 urine) metabolites, respectively, of which 45 (27 urine) were common to both. Major metabolic pathways were branched-chain amino acid metabolism (partially independent of insulin resistance), surrogate markers of oxidative stress and gut microbial diversity, and cortisol metabolism. We observed a novel positive association between VAT and plasma levels of the potential pharmacological agent piperine. Sex-specific effects were only a few, e.g. the female-specific association between VAT and O-methylascorbate. In brief, higher VAT was associated with an unfavorable metabolite profile in a sample of healthy, mostly non-obese individuals from the general population and only few sex-specific associations became apparent.
C1 [Otto, Lerina; Budde, Kathrin; Kaul, Anne; Nauck, Matthias; Friedrich, Nele; Pietzner, Maik] Univ Med Greifswald, Inst Clin Chem & Lab Med, Greifswald, Germany.
   [Budde, Kathrin; Voelker, Uwe; Voelzke, Henry; Nauck, Matthias; Friedrich, Nele; Pietzner, Maik] DZHK German Ctr Cardiovasc Res, Partner Site Greifswald, Greifswald, Germany.
   [Kastenmueller, Gabi] Helmholtz Zentrum Munchen, Inst Bioinformat & Syst Biol, Neuherberg, Germany.
   [Voelker, Uwe] Univ Med, Interfac Inst Genet & Funct Genom, Greifswald, Germany.
   [Voelker, Uwe] Ernst Moritz Arndt Univ Greifswald, Greifswald, Germany.
   [Voelzke, Henry] Univ Med Greifswald, Inst Community Med, D-17475 Greifswald, Germany.
   [Voelzke, Henry] DZD German Ctr Diabet Res, Site Greifswald, D-17475 Greifswald, Germany.
   [Adamski, Jerzy; Artati, Anna] Helmholtz Zentrum Munchen, Genome Anal Ctr, Inst Expt Genet, Neuherberg, Germany.
   [Adamski, Jerzy] Tech Univ Munich, Lehrstuhl Expt Genet, Freising Weihenstephan, Germany.
   [Adamski, Jerzy] DZD German Ctr Diabet Res, Munich, Germany.
   [Kuehn, Jens P.] Univ Med Greifswald, Inst Diagnost Radiol & Neuroradiol, Greifswald, Germany.
   [Kuehn, Jens P.] Carl Gustav Carus Univ Dresden, Univ Med, Inst Diagnost Radiol, Dresden, Germany.
   [Krumsiek, Jan] Helmholtz Zentrum Munchen, ICB Inst Computat Biol, D-85764 Neuherberg, Germany.
   [Krumsiek, Jan] Weill Cornell Med, Dept Physiol & Biophys, Englander Inst Precis Med, Inst Computat Biomed, New York, NY USA.
C3 Universitat Greifswald; Greifswald Medical School; German Centre for
   Cardiovascular Research; Helmholtz Association; Helmholtz-Center Munich
   - German Research Center for Environmental Health; Universitat
   Greifswald; Universitat Greifswald; Greifswald Medical School; German
   Center for Diabetes Research (DZD); Helmholtz Association;
   Helmholtz-Center Munich - German Research Center for Environmental
   Health; Technical University of Munich; German Center for Diabetes
   Research (DZD); Universitat Greifswald; Greifswald Medical School;
   Technische Universitat Dresden; Carl Gustav Carus University Hospital;
   Helmholtz Association; Helmholtz-Center Munich - German Research Center
   for Environmental Health; Cornell University; Weill Cornell Medicine
RP Pietzner, M (corresponding author), Univ Med Greifswald, Inst Clin Chem & Lab Med, Greifswald, Germany.; Pietzner, M (corresponding author), DZHK German Ctr Cardiovasc Res, Partner Site Greifswald, Greifswald, Germany.
EM maik.pietzner@med.uni-greifswald.de
RI Kastenmüller, Gabi/ABF-5987-2020; Krumsiek, Jan/B-3961-2013
OI Adamski, Jerzy/0000-0001-9259-0199; Pietzner, Maik/0000-0003-3437-9963;
   Kastenmuller, Gabi/0000-0002-2368-7322
FU German Federal Ministry of Education and Research (BMBF) [01ZZ0403,
   01ZZ0103, 01GI0883, AtheroSysMed 03IS2061B]; Ministry for Education,
   Research and Cultural Affairs; Ministry of Social Affairs of the Federal
   State of Mecklenburg-West Pomerania; Federal Ministry of Education and
   Research; Ministry of Cultural Affairs of the Federal State of
   Mecklenburg-West Pomerania [03IS2061A]; German Center Diabetes Research
   (DZD e.V.) grant
FX This work was funded by grants from the German Federal Ministry of
   Education and Research (BMBF, grants 01ZZ0403, 01ZZ0103, 01GI0883,
   AtheroSysMed 03IS2061B), the Ministry for Education, Research and
   Cultural Affairs, as well as the Ministry of Social Affairs of the
   Federal State of Mecklenburg-West Pomerania. This work is also part of
   the research project Greifswald Approach to Individualized Medicine
   (GANI_MED). The GANI_MED consortium is funded by the Federal Ministry of
   Education and Research and the Ministry of Cultural Affairs of the
   Federal State of Mecklenburg-West Pomerania (03IS2061A). A part of this
   study was supported by the German Center Diabetes Research (DZD e.V.)
   grant to J.A. We would like to thank Bianca Schmick from Genome Analysis
   Center for expert technical assistance.
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NR 67
TC 8
Z9 8
U1 3
U2 6
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD JAN 30
PY 2020
VL 10
IS 1
AR 1487
DI 10.1038/s41598-020-58430-8
PG 11
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA NB3NL
UT WOS:000560422200013
PM 32001750
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Csáky, Z
   Garaiová, M
   Kodedová, M
   Valachovic, M
   Sychrová, H
   Hapala, I
AF Csaky, Zsofia
   Garaiova, Martina
   Kodedova, Marie
   Valachovic, Martin
   Sychrova, Hana
   Hapala, Ivan
TI Squalene lipotoxicity in a lipid droplet-less yeast mutant is linked to
   plasma membrane dysfunction
SO YEAST
LA English
DT Article
DE lipid droplet; lipotoxicity; plasma membrane; squalene; yeast
ID NONBILAYER STRUCTURES; METABOLIC SYNDROME; MODEL SYSTEM; CELL-WALL;
   ERGOSTEROL; ORGANIZATION; MECHANISM; ACCUMULATION; PERMEABILITY;
   CHOLESTEROL
AB Squalene is a naturally occurring triterpene with wide industrial applications. Due to limited natural resources, production of this valuable lipid in yeast is of high commercial relevance. Typically low levels of squalene in yeast can be significantly increased by specific cultivation conditions or genetic modifications. Under normal conditions, excess squalene is stored in lipid droplets (LD), while in a Saccharomyces cerevisiae mutant unable to form LD it is distributed to cellular membranes. We present here the evidence that squalene accumulation in this LD-less mutant treated with squalene monooxygenase inhibitor terbinafine induces growth defects and loss of viability. We show that plasma membrane malfunction is involved in squalene toxicity. We have found that subinhibitory concentrations of terbinafine increased the sensitivity of LD-less mutant to several membrane-active substances. Furthermore, squalene accumulation in terbinafine-treated LD-less cells disturbed the maintenance of membrane potential and increased plasma membrane permeability to rhodamine 6G. LD-less cells treated with terbinafine showed also high sensitivity to osmotic stress. To confirm the causal relationship between squalene accumulation, loss of viability and impaired plasma membrane functions we treated LD-less cells simultaneously with terbinafine and squalene synthase inhibitor zaragozic acid. Reduction of squalene levels by zaragozic acid improved cell growth and viability and decreased plasma membrane permeability to rhodamine 6G in terbinafine-treated LD-less cells. Our results support the hypothesis that plasma membrane malfunction is involved in the mechanisms of squalene lipotoxicity in yeast cells with defective lipid storage.
C1 [Csaky, Zsofia; Garaiova, Martina; Valachovic, Martin; Hapala, Ivan] Slovak Acad Sci, Inst Anim Biochem & Genet, Dept Membrane Biochem, Ctr Biosci, Bratislava, Slovakia.
   [Kodedova, Marie; Sychrova, Hana] Czech Acad Sci, Dept Membrane Transport, Div BIOCEV, Inst Physiol, Prague, Czech Republic.
C3 Slovak Academy of Sciences; Centre of Biosciences, SAS; Institute of
   Animal Biochemistry & Genetics, SAS; Czech Academy of Sciences;
   Institute of Physiology of the Czech Academy of Sciences
RP Hapala, I (corresponding author), Slovak Acad Sci, Inst Anim Biochem & Genet, Ctr Biosci, Dubravska Cesta 9, Bratislava 84005, Slovakia.
EM ivan.hapala@savba.sk
RI Hapala, Ivan/ABB-5807-2021; Valachovic, Martin/O-5962-2017; Sychrova,
   Hana/B-1350-2012; Kodedova, Marie/B-7559-2012
OI Sychrova, Hana/0000-0001-5967-5019; Hapala, Ivan/0000-0002-2305-8112;
   Garaiova, Martina/0000-0003-2486-0059; Kodedova,
   Marie/0000-0003-3423-2363; Valachovic, Martin/0000-0001-7096-9325
FU Czech National Sustainability Program II [CZ.1.05/1.1.00/02.0109]; CAS
   [SAV-16-12]; SAS [SAV-16-12]; Ministry of Education, Youth and Sports of
   CR [LQ1604]; Slovak Research and Development Agency [APVV-15-0654];
   Scientific Grant Agency of the Ministry of Education, Science, Research
   and Sport of the Slovak Republic [VEGA-2-0064-16]; Slovak Academy of
   Sciences [VEGA-2-0064-16]
FX Czech National Sustainability Program II, Grant/Award Number:
   CZ.1.05/1.1.00/02.0109; Bilateral Mobility Project between CAS and SAS,
   Grant/Award Number: SAV-16-12 to M.K. and M.V.; Ministry of Education,
   Youth and Sports of CR, Grant/Award Number: LQ1604; Slovak Research and
   Development Agency, Grant/Award Number: APVV-15-0654 to I.H.; Scientific
   Grant Agency of the Ministry of Education, Science, Research and Sport
   of the Slovak Republic and the Slovak Academy of Sciences, Grant/Award
   Number: VEGA-2-0064-16 to I.H.
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NR 67
TC 22
Z9 24
U1 0
U2 27
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0749-503X
EI 1097-0061
J9 YEAST
JI Yeast
PD JAN
PY 2020
VL 37
IS 1
BP 45
EP 62
DI 10.1002/yea.3454
EA JAN 2020
PG 18
WC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
   Microbiology; Mycology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
   Microbiology; Mycology
GA KC3UH
UT WOS:000505557700001
PM 31826302
DA 2025-06-11
ER

PT J
AU Alsabieh, M
   Alqahtani, M
   Altamimi, A
   Albasha, A
   Alsulaiman, A
   Alkhamshi, A
   Habib, SS
   Bashir, S
AF Alsabieh, Mohammad
   Alqahtani, Mohammad
   Altamimi, Abdulaziz
   Albasha, Abdullah
   Alsulaiman, Alwaleed
   Alkhamshi, Abdullah
   Habib, Syed Shahid
   Bashir, Shahid
TI Fast food consumption and its associations with heart rate, blood
   pressure, cognitive function and quality of life. Pilot study
SO HELIYON
LA English
DT Article
DE Food science; Neuroscience
ID SUGAR-SWEETENED BEVERAGES; TYPE-2 DIABETES-MELLITUS; METABOLIC SYNDROME;
   FRUCTOSE; OBESITY; HEALTH; RISK; PREVALENCE; NUTRITION; IMPACT
AB Background: To investigate the relationship of fast food consumption with cognitive and metabolic function of adults (18-25 years old) in Riyadh, Kingdom of Saudi Arabia. Materials and
   Method: This cross-sectional study was conducted at the College of Medicine at King Khalid University Hospital, Riyadh, Saudi Arabia. The conventionally recruited subjects underwent an evaluation that included demographic data, quality of life (wellness, stress, sleepiness, and physical activity), mini-mental status examination, and the frequency of fast food consumption. To investigate metabolic function, blood was drawn to evaluate serum HDL, LDL, cholesterol, and triglyceride levels. Cognitive function was assessed by the Cambridge neuropsychological test automated battery. The participants were divided into 2 groups based on fast food consumption: those who consumed fast food 3 times per week or less (Group 1) and those who consumed fast food more than 3 times per week (Group 2).
   Results: The mean diastolic blood pressure in Group 1 and Group 2 was 72 mmHg and 77 mmHg, respectively, a significant difference (p = 0.04). There was no significant difference for cognitive function and quality of life between the two groups. There was significant correlation of HDL with AST correct mean latency and the AST correct mean latency congruent (p = 0.02, p = 0.01, respectively) and TC with diastolic blood pressure (p = 0.003).
   Conclusions: We concluded that fast food consumption has an effect on blood pressure but has no direct effect on cognition or quality of life.
C1 [Alsabieh, Mohammad; Alqahtani, Mohammad; Altamimi, Abdulaziz; Albasha, Abdullah; Alsulaiman, Alwaleed; Alkhamshi, Abdullah; Habib, Syed Shahid] King Saud Univ, Coll Med, Riyadh, Saudi Arabia.
   [Bashir, Shahid] King Fahad Specialist Hosp Dammam, Neurosci Ctr, Dammam, Saudi Arabia.
C3 King Saud University
RP Bashir, S (corresponding author), King Fahad Specialist Hosp Dammam, Neurosci Ctr, Dammam, Saudi Arabia.
EM sbashir10@gmail.com
RI Habib, Syed/ABD-2283-2020; Bashir, Shahid/HOA-8856-2023
OI Bashir, Shahid/0000-0001-6286-6895
FU Deanship of Scientific Research [RGP-1438-048]; King Saud University,
   Riyadh, Saudi Arabia
FX This study was supported by a grant from Deanship of Scientific Research
   (Grant Number: RGP-1438-048) King Saud University, Riyadh, Saudi Arabia.
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PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
EI 2405-8440
J9 HELIYON
JI Heliyon
PD MAY
PY 2019
VL 5
IS 5
AR e01566
DI 10.1016/j.heliyon.2019.e01566
PG 6
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA IG1OR
UT WOS:000473561400011
PM 31193345
OA Green Published
DA 2025-06-11
ER

PT J
AU Piao, ZY
   Zhai, BQ
   Jiang, XX
   Dong, M
   Yan, CG
   Lin, J
   Jin, WZ
AF Piao, Zhengyu
   Zhai, Baiqiang
   Jiang, Xiaoxiao
   Dong, Meng
   Yan, Changguo
   Lin, Jun
   Jin, Wanzhu
TI Reduced adiposity by compensatory WAT browning upon iBAT removal in mice
SO BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
LA English
DT Article
DE Beige adipocytes formation; Obesity; iBAT removal
ID NONSHIVERING THERMOGENESIS; ADAPTIVE THERMOGENESIS;
   ADRENERGIC-STIMULATION; WHITE FAT; TISSUE; COLD; ADIPOCYTES; BEIGE;
   PGC-1-ALPHA; HUMANS
AB The strong effects of classic brown adipose tissue (BAT) and recruited beige adipocytes in treatment of obesity and metabolic syndrome have been attracting increasing research interest. Cold treatment is an effective, convenient approach to stimulate BAT activity and induce white adipose tissue (WAT) browning. Here, we utilized prolonged cold exposure (from 2 h to 2 weeks in a 4 degrees cold chamber) to elucidate dynamic changes in BAT and in WAT browning during acute and chronic cold exposure in mice. BAT mass decreased quickly, with reduced lipid droplet sizes within 8 h of cold exposure owing to the utilization of BAT pre-storage triglycerides, and subsequently increased during prolonged cold exposure. These dynamic morphological changes in BAT were confirmed by gene expression changes in ADRB3 and PGC1 alpha, while UCP1 and ELOVL3 expression was continuously up-regulated throughout the entire cold exposure period. Additionally, cold treatment increased BAT secretion of FGF21, which has been reported to activate beige adipocyte formation. Thus, to illustrate potential crosstalk between secreted BAT proteins (so-called BATokines) and beige adipogenesis during cold stress, we performed an interscapular BAT (iBAT) removal experiment in mice. Surprisingly, loss of classic iBAT enhanced WAT browning due to compensatorily increased sympathetic WAT input. Unexpectedly, we observed significantly reduced adiposity in the iBAT removal group compared with the control group. These results further suggest that WAT browning plays an important role in whole-body energy metabolism during cold acclimation, even without iBAT. Furthermore, our data imply that enhanced WAT browning may be an efficient therapeutic tool to combat obesity and related syndromes. (C) 2018 Elsevier Inc. All rights reserved.
C1 [Piao, Zhengyu; Yan, Changguo] Yanbian Univ, Dept Anim Sci, Yanji 133002, Peoples R China.
   [Jiang, Xiaoxiao; Dong, Meng; Lin, Jun; Jin, Wanzhu] Chinese Acad Sci, Inst Zool, Key Lab Anim Ecol & Conservat Biol, Beijing 100101, Peoples R China.
   [Jiang, Xiaoxiao; Dong, Meng; Lin, Jun] Univ Chinese Acad Sci, Coll Life Sci, Beijing 100049, Peoples R China.
   [Zhai, Baiqiang] China Agr Univ, Coll Food Sci & Nutr Engn, Lab Food Safety, Beijing 100083, Peoples R China.
   [Zhai, Baiqiang] China Agr Univ, Coll Food Sci & Nutr Engn, Beijing Adv Innovat Ctr Food Nutr & Human Hlth, Beijing 100083, Peoples R China.
   [Jin, Wanzhu] Univ Chinese Acad Sci, Savaid Med Sch, Beijing 100049, Peoples R China.
C3 Yanbian University; Chinese Academy of Sciences; Institute of Zoology,
   CAS; Chinese Academy of Sciences; University of Chinese Academy of
   Sciences, CAS; China Agricultural University; China Agricultural
   University; Chinese Academy of Sciences; University of Chinese Academy
   of Sciences, CAS
RP Yan, CG (corresponding author), Yanbian Univ, Dept Anim Sci, Yanji 133002, Peoples R China.; Lin, J (corresponding author), Univ Chinese Acad Sci, Coll Life Sci, Beijing 100049, Peoples R China.
EM ycg@ybu.edu.cn; cleverlinjun@126.com
RI Dong, Meng/AAI-6235-2021; Jin, Wanzhu/B-5699-2012
FU Strategic Priority Research Program of CAS [XDB 13030000]; National
   Basic Research Program of China [2015CB943102]
FX This study was supported by the Strategic Priority Research Program of
   CAS (XDB 13030000) and National Basic Research Program of China Grants
   (2015CB943102).
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NR 37
TC 17
Z9 18
U1 1
U2 23
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0006-291X
EI 1090-2104
J9 BIOCHEM BIOPH RES CO
JI Biochem. Biophys. Res. Commun.
PD JUN 27
PY 2018
VL 501
IS 3
BP 807
EP 813
DI 10.1016/j.bbrc.2018.05.089
PG 7
WC Biochemistry & Molecular Biology; Biophysics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics
GA GK3PL
UT WOS:000436057500030
PM 29775611
DA 2025-06-11
ER

EF﻿FN Clarivate Analytics Web of Science
VR 1.0
PT J
AU Willig, AL
   Kramer, PA
   Chacko, BK
   Darley-Usmar, VM
   Heath, SL
   Overton, ET
AF Willig, Amanda L.
   Kramer, Philip A.
   Chacko, Balu K.
   Darley-Usmar, Victor M.
   Heath, Sonya L.
   Overton, E. Turner
TI Monocyte bioenergetic function is associated with body composition in
   virologically suppressed HIV-infected women
SO REDOX BIOLOGY
LA English
DT Article
DE Bioenergetics; Mitochondria; Women; HIV; Obesity; Body composition
ID OXIDATIVE STRESS; MITOCHONDRIAL-DNA; INSULIN-RESISTANCE; METABOLIC
   SYNDROME; PERIPHERAL-BLOOD; ADIPOSE-TISSUE; HEALTH INDEX; OBESITY; RISK;
   PREVALENCE
AB Women living with HIV may present with high levels of body fat that are associated with altered bioenergetic function. Excess body fat may therefore exacerbate the bioenergetic dysfunction observed with HIV infection. To determine if body fat is associated with bioenergetic function in HIV, we conducted a cross-sectional study of 42 women with HIV who were virologically suppressed on antiretroviral therapy. Body composition was determined via dual-energy x-ray absorptiometry. Oxygen consumption rate (OCR) of monocytes was sorted from peripheral blood mononuclear cells obtained from participants in the fasting state. Differences in bioenergetic function, as measured by OCR, was assessed using Kruskal-Wallis tests and Spearman correlations adjusted for age, race, and smoking status. Participants were 86% Black, 45.5 years old, 48% current smokers, and 57% were obese (body mass index >= 30). Nearly all women (93%) had> 30% total fat mass, while 12% had> 50% total fat mass. Elevated levels of total fat mass, trunk fat, and leg fat were inversely correlated with measures of bioenergetic health as evidenced by lower maximal and reserve capacity OCR, and Bioenergetic Health Index. Measures of extracellular acidification (ECAR) in the absence (basal) or maximal (with oligomycin) were positively correlated with measures of bioenergetics, except proton leak, and were negatively correlated with fat mass. Despite virological suppression, women with HIV present with extremely high levels of adiposity that correlate with impaired bioenergetic health. Without effective interventions, this syndemic of HIV infection and obesity will likely have devastating consequences for our patients, potentially mediated through altered mitochondrial and glycolytic function.
C1 [Willig, Amanda L.; Heath, Sonya L.; Overton, E. Turner] Univ Alabama Birmingham, Dept Med, Div Infect Dis, Birmingham, AL 35294 USA.
   [Kramer, Philip A.; Chacko, Balu K.; Darley-Usmar, Victor M.] Univ Alabama Birmingham, Mitochondrial Med Lab, Birmingham, AL 35294 USA.
   [Darley-Usmar, Victor M.] Univ Alabama Birmingham, Dept Pathol, Birmingham, AL 35294 USA.
C3 University of Alabama System; University of Alabama Birmingham;
   University of Alabama System; University of Alabama Birmingham;
   University of Alabama System; University of Alabama Birmingham
RP Willig, AL (corresponding author), Univ Alabama Birmingham, Ctr AIDS Res, 845 19th St S,BBRB 203, Birmingham, AL 35294 USA.
EM mandyrd@uab.edu; pkramer@uw.edu; bchacko@uab.edu;
   vdarleyusmar@uabmc.edu; heaths@uab.edu; toverton@uab.edu
RI Darley-Usmar, Victor/F-7656-2010; Kramer, Philip/GYJ-8215-2022
OI Overton, Edgar/0000-0002-4013-536X; Kramer, Philip/0000-0001-6554-631X;
   Darley-Usmar, Victor/0000-0001-8921-7086
FU Mid-South Transdisciplinary Collaborative Center for Health Disparities
   Research (NIMHD) [U54MD008176]; UAB Center for AIDS Research
   [P30-AI27767]; Mary Fisher CARE Fund; UAB Nutrition Obesity Research
   Center [P30DK56336]; UAB Diabetes Research Center [P60DK079626]; UAB
   Center for Clinical and Translational Science [UL1TR001417]; UAB Blue
   Sky program; NIH [T32HL07918]
FX This study was supported by the Mid-South Transdisciplinary
   Collaborative Center for Health Disparities Research (NIMHD grant
   U54MD008176), the UAB Center for AIDS Research (grant P30-AI27767), the
   Mary Fisher CARE Fund, the UAB Nutrition Obesity Research Center
   (P30DK56336), and the UAB Diabetes Research Center (P60DK079626). A.L.W.
   received financial support from the UAB Center for Clinical and
   Translational Science (UL1TR001417). VDU received support from the UAB
   Blue Sky program. P.A.K. received financial support from NIH training
   grant T32HL07918. No financial disclosures were reported by the authors
   of this paper.
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NR 45
TC 22
Z9 22
U1 0
U2 3
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2213-2317
J9 REDOX BIOL
JI Redox Biol.
PD AUG
PY 2017
VL 12
BP 648
EP 656
DI 10.1016/j.redox.2017.04.005
PG 9
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA EX6CA
UT WOS:000403328700060
PM 28395172
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Zhang, YM
   Ren, J
AF Zhang, Yingmei
   Ren, Jun
TI Epigenetics and obesity cardiomyopathy: From pathophysiology to
   prevention and management
SO PHARMACOLOGY & THERAPEUTICS
LA English
DT Review
DE Obesity; Adipose tissue; Liver; Cardiac; Histone modification;
   Methylation
ID BODY-MASS INDEX; WIDE DNA METHYLATION; HUMAN ADIPOSE-TISSUE; EARLY-LIFE;
   CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; CHILDHOOD OBESITY;
   GENE-EXPRESSION; TRANSGENERATIONAL INHERITANCE; IMPRINTING DISORDERS
AB Uncorrected obesity has been associated with cardiac hypertrophy and contractile dysfunction. Several mechanisms for this cardiomyopathy have been identified, including oxidative stress, autophagy, adrenergic and renin-angiotensin aldosterone overflow. Another process that may regulate effects of obesity is epigenetics, which refers to the heritable alterations in gene expression or cellular phenotype that are not encoded on the DNA sequence. Advances in epigenome profiling have greatly improved the understanding of the epigenome in obesity, where environmental exposures during early life result in an increased health risk later, on in life. Several mechanisms, including histone modification, DNA methylation and non-coding RNAs, have been reported in obesity and can cause transcriptional suppression or activation, depending on the location within the gene, contributing to obesity-induced complications. Through epigenetic modifications, the fetus may be prone to detrimental insults, leading to cardiac sequelae later in life. Important links between epigenetics and obesity include nutrition, exercise, adiposity, inflammation, insulin sensitivity and hepatic steatosis. Genome-wide studies have identified altered DNA methylation patterns in pancreatic islets, skeletal muscle and adipose tissues from obese subjects compared with non-obese controls. In addition, aging and intrauterine environment are associated with differential DNA methylation. Given the intense research on the molecular mechanisms of the etiology of obesity and its complications, this review will provide insights into the current understanding of epigenetics and pharmacological and non-pharmacological (such as exercise) interventions targeting epigenetics as they relate to treatment of obesity and its complications. Particular focus will be on DNA methylation, histone modification and non-coding RNAs. (C) 2016 Elsevier Inc. All rights reserved.
C1 [Zhang, Yingmei; Ren, Jun] Fudan Univ, Zhongshan Hosp, Shanghai Inst Cardiovasc Dis, Shanghai 200032, Peoples R China.
   Univ Wyoming, Coll Hlth Sci, Ctr Cardiovasc Res & Alternat Med, Laramie, WY 82071 USA.
C3 Fudan University; University of Wyoming
RP Zhang, YM; Ren, J (corresponding author), Fudan Univ, Zhongshan Hosp, Shanghai Inst Cardiovasc Dis, Shanghai 200032, Peoples R China.
EM zhangym197951@126.com; ren.jun@zs-hospital.sh.cn
RI Ren, Jun/ACG-5366-2022
OI Ren, Jun/0000-0002-0275-0783
FU NIH [5P20GM103432]; American Diabetes Association [7-13-BS-142-BR]; NSFC
   [1570225, 81522004]
FX Work carried out in the authors' laboratories has been supported in part
   by the NIH (5P20GM103432), American Diabetes Association
   (7-13-BS-142-BR) and NSFC (1570225, 81522004). We wish to express our
   sincere apology to those authors whose important work cannot be included
   due to space limitations,
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NR 187
TC 97
Z9 103
U1 1
U2 27
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0163-7258
EI 1879-016X
J9 PHARMACOL THERAPEUT
JI Pharmacol. Ther.
PD MAY
PY 2016
VL 161
BP 52
EP 66
DI 10.1016/j.pharmthera.2016.03.005
PG 15
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA DL8IV
UT WOS:000375886600005
PM 27013344
DA 2025-06-11
ER

PT J
AU Meza-Miranda, ER
   Rangel-Zúñiga, OA
   Marín, C
   Pérez-Martínez, P
   Delgado-Lista, J
   Haro, C
   Peña-Orihuela, P
   Jiménez-Morales, AI
   Malagón, MM
   Tinahones, FJ
   López-Miranda, J
   Pérez-Jiménez, F
   Camargo, A
AF Meza-Miranda, Eliana R.
   Rangel-Zuniga, Oriol A.
   Marin, Carmen
   Perez-Martinez, Pablo
   Delgado-Lista, Javier
   Haro, Carmen
   Pena-Orihuela, Patricia
   Jimenez-Morales, Ana I.
   Malagon, Maria M.
   Tinahones, Francisco J.
   Lopez-Miranda, Jose
   Perez-Jimenez, Francisco
   Camargo, Antonio
TI Virgin olive oil rich in phenolic compounds modulates the expression of
   atherosclerosis-related genes in vascular endothelium
SO EUROPEAN JOURNAL OF NUTRITION
LA English
DT Article
DE Phenolic compounds; Virgin olive oil; Vascular endothelium; Gene
   expression; HUVEC
ID NAD(P)H OXIDASE ACTIVATION; NF-KAPPA-B; METABOLIC SYNDROME; OXIDATIVE
   STRESS; MEDITERRANEAN DIET; CARDIOVASCULAR-DISEASE; MONONUCLEAR-CELLS;
   ARACHIDONIC-ACID; MINOR COMPONENTS; INFLAMMATION
AB Previous studies have shown the anti-inflammatory and antioxidant properties of phenolic compounds of virgin olive oil (VOO). However, the effect of bioavailable phenolic compounds on the vascular endothelium is unknown. We aimed to evaluate the effect of the consumption of virgin olive oil rich in phenolic compounds on the vascular endothelium.
   We treated HUVEC with human serum obtained in fasting state and after the intake of a breakfast prepared with VOO with a high or low content of phenolic compounds.
   Treatment of HUVEC with serum obtained 2 h after the intake of the high-phenol VOO-based breakfast decreased p65 and MCP-1 gene expression (p < 0.001 and p = 0.002, respectively) and increased MT-CYB, SDHA and SOD1 gene expression (p = 0.004, p = 0.012 and p = 0.001, respectively), as compared with the treatment of HUVEC with the serum obtained 2 h after the intake of the low-phenol VOO-based breakfast. The treatment with serum obtained 4 h after the intake of the high-phenol VOO-based breakfast decreased MCP-1 and CAT gene expression (p < 0.001 and p = 0.003, respectively) and increased MT-CYB gene expression (p < 0.001), as compared to the treatment with serum obtained 4 h after the intake of the low-phenol VOO-based breakfast.
   Our results suggest that the consumption of virgin olive oil rich in phenolic compounds may reduce the risk of atherosclerosis development by decreasing inflammation and improving the antioxidant profile in the vascular endothelium.
C1 [Meza-Miranda, Eliana R.; Rangel-Zuniga, Oriol A.; Marin, Carmen; Perez-Martinez, Pablo; Delgado-Lista, Javier; Haro, Carmen; Pena-Orihuela, Patricia; Jimenez-Morales, Ana I.; Lopez-Miranda, Jose; Perez-Jimenez, Francisco; Camargo, Antonio] Univ Cordoba, Lipids & Atherosclerosis Unit, Reina Sofia Univ Hosp, IMIBIC, Av Menendez Pidal S-N, E-14004 Cordoba, Spain.
   [Meza-Miranda, Eliana R.; Rangel-Zuniga, Oriol A.; Marin, Carmen; Perez-Martinez, Pablo; Delgado-Lista, Javier; Haro, Carmen; Pena-Orihuela, Patricia; Jimenez-Morales, Ana I.; Malagon, Maria M.; Tinahones, Francisco J.; Lopez-Miranda, Jose; Perez-Jimenez, Francisco; Camargo, Antonio] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr CIBEROBN, Madrid, Spain.
   [Malagon, Maria M.] Univ Cordoba, Dept Cell Biol Physiol & Immunol, IMIBIC, Reina Sofia Univ Hosp, E-14004 Cordoba, Spain.
   [Tinahones, Francisco J.] Hosp Virgen Victoria, Endocrinol & Nutr Serv, Malaga, Spain.
C3 Universidad de Cordoba; Instituto de Salud Carlos III; CIBER - Centro de
   Investigacion Biomedica en Red; CIBEROBN; Universidad de Cordoba
RP Camargo, A (corresponding author), Univ Cordoba, Lipids & Atherosclerosis Unit, Reina Sofia Univ Hosp, IMIBIC, Av Menendez Pidal S-N, E-14004 Cordoba, Spain.
EM antonio.camargo@imibic.org
RI Marin Hinojosa, Carmen/AFO-1294-2022; Lopez-Miranda, Jose/Y-8306-2019;
   Delgado-Lista, Javier/KAM-7412-2024; Jimenez, Francisco/AAJ-9559-2021;
   Tinahones, Francisco/AAB-2882-2020; Perez Martinez, Pablo/AEL-6176-2022;
   Camargo Garcia, Antonio/G-9720-2015; MALAGON, MARIA M/L-5386-2014; HARO,
   CARMEN/P-3104-2016
OI Perez Martinez, Pablo/0000-0001-7716-8117; Tinahones, Francisco
   J/0000-0001-6871-4403; Delgado Lista, Francisco
   Javier/0000-0002-2982-2716; Pena Orihuela, Patricia
   J/0009-0009-9970-043X; Camargo Garcia, Antonio/0000-0002-0415-4184;
   Lopez-Miranda, Jose/0000-0002-8844-0718; Rangel-Zuniga, Oriol
   Alberto/0000-0003-3495-5705; MALAGON, MARIA M/0000-0002-2419-2727; HARO,
   CARMEN/0000-0002-1355-8359; Meza Miranda, Eliana
   Romina/0000-0001-9791-8835
FU Spanish Ministry of Science and Innovation [AGL 2006-01979, AGL
   2009-12270, SAF07-62005, PI10/02412]; Consejeria de Economia, Innovacion
   y Ciencia, Proyectos de Investigacion de Excelencia, Junta de Andalucia
   [P06-CTS-01425, CTS5015, AGR922]; Consejeria de Salud, Junta de
   Andalucia [06/128, 07/43, PI0193/09, 06/129, 06/127, PI-0252/09,
   PI-0058/10]; Fondo Europeo de Desarrollo Regional (FEDER)
FX The CIBEROBN is an initiative of the Instituto de Salud Carlos III,
   Madrid, Spain. This study supported in part by research grants from the
   Spanish Ministry of Science and Innovation (AGL 2006-01979, and AGL
   2009-12270 to J. L.-M., SAF07-62005 to F. P.-J., PI10/02412 to F.
   P.-J.); Consejeria de Economia, Innovacion y Ciencia, Proyectos de
   Investigacion de Excelencia, Junta de Andalucia (P06-CTS-01425 to J.
   L.-M., CTS5015 and AGR922 to F. P.-J.); Consejeria de Salud, Junta de
   Andalucia (06/128, 07/43, and PI0193/09 to J. L.-M, 06/129 to F. P.-J.,
   06/127 to C. M.-H., PI-0252/09 to J. D.-L., and PI-0058/10 to P. P.-M.);
   Fondo Europeo de Desarrollo Regional (FEDER). We would also like to
   thank Canoliva (Antonio Cano e Hijos SA, Luque, Cordoba), who generously
   donated the olive oil.
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NR 53
TC 18
Z9 19
U1 0
U2 21
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1436-6207
EI 1436-6215
J9 EUR J NUTR
JI Eur. J. Nutr.
PD MAR
PY 2016
VL 55
IS 2
BP 519
EP 527
DI 10.1007/s00394-015-0868-3
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA DF3RD
UT WOS:000371262400008
PM 25733165
DA 2025-06-11
ER

PT J
AU Abdulla, MH
   Sattar, MA
   Johns, EJ
AF Abdulla, Mohammed H.
   Sattar, Munavvar A.
   Johns, Edward J.
TI Effects of tempol on altered metabolism and renal vascular
   responsiveness in fructose-fed rats
SO APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
LA English
DT Article
DE Sprague-Dawley rats; tempol; hypertension; angiotensin II; fructose
ID ANGIOTENSIN-II; OXIDATIVE STRESS; BLOOD-PRESSURE; NADPH OXIDASE;
   ENDOTHELIAL DYSFUNCTION; ANTIOXIDANT TEMPOL; ARTERIAL-PRESSURE;
   SUPEROXIDE; HYPERTENSION; INSULIN
AB This study investigated the effect of tempol (a superoxide dismutase mimetic) on renal vasoconstrictor responses to angiotensin II (Ang II) and adrenergic agonists in fructose-fed Sprague-Dawley rats (a model of metabolic syndrome). Rats were fed 20% fructose in drinking water (F) for 8 weeks. One fructose-fed group received tempol (FT) at 1 mmol.L-1 in drinking water for 8 weeks or as an infusion (1.5 mg.kg(-1).min(-1)) intrarenally. At the end of the treatment regimen, the renal responses to noradrenaline, phenylephrine, methoxamine, and Ang II were determined. F rats exhibited hyperinsulinemia, hyperuricemia, hypertriglyceridemia, and hypertension. Tempol reduced blood glucose and insulin levels (all p < 0.05) in FT rats compared with their untreated counterparts. The vasoconstriction response to all agonists was lower in F rats than in control rats by about 35%-65% (all p < 0.05). Vasoconstrictor responses to noradrenaline, phenylephrine, and methoxamine but not Ang II were about 41%-75% higher in FT rats compared with F rats (all p < 0.05). Acute tempol infusion blunted responses to noradrenaline, methoxamine, and Ang II in control rats by 32%, 33%, and 62%, while it blunted responses to noradrenaline and Ang II in F rats by 26% and 32%, respectively (all p < 0.05), compared with their untreated counterparts. Superoxide radicals play a crucial role in controlling renal vascular responses to adrenergic agonists in insulin-resistant rats. Chronic but not acute tempol treatment enhances renal vascular responsiveness in fructose-fed rats.
C1 [Abdulla, Mohammed H.; Johns, Edward J.] Natl Univ Ireland Univ Coll Cork, Sch Med, Dept Physiol, Cork, Ireland.
   [Sattar, Munavvar A.] Univ Sains Malaysia, Sch Pharmaceut Sci, Minden 11800, Penang, Malaysia.
C3 University College Cork; Universiti Sains Malaysia
RP Abdulla, MH (corresponding author), Natl Univ Ireland Univ Coll Cork, Sch Med, Dept Physiol, Cork, Ireland.
EM m.abdulla@ucc.ie
RI Abdulla, Mohammed/V-4987-2019
OI Abdulla, Mohammed/0000-0001-5496-5017
FU Universiti Sains Malaysia
FX Mohammed H. Abdulla is a recipient of the Vice Chancellor's award for
   research from Universiti Sains Malaysia.
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NR 57
TC 3
Z9 3
U1 0
U2 2
PU CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS
PI OTTAWA
PA 65 AURIGA DR, SUITE 203, OTTAWA, ON K2E 7W6, CANADA
SN 1715-5312
EI 1715-5320
J9 APPL PHYSIOL NUTR ME
JI Appl. Physiol. Nutr. Metab.
PD FEB
PY 2016
VL 41
IS 2
BP 210
EP 218
DI 10.1139/apnm-2015-0411
PG 9
WC Nutrition & Dietetics; Physiology; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics; Physiology; Sport Sciences
GA DD6LU
UT WOS:000370036500012
PM 26789093
DA 2025-06-11
ER

PT J
AU Wen, YF
   Xia, D
   Wang, YC
   Zhang, HP
   Li, HB
   Ali, G
   Gao, YQ
   Li, J
   Sun, WJ
   Li, LL
AF Wen, Yufeng
   Xia, Dan
   Wang, Yanchun
   Zhang, Huiping
   Li, Haibo
   Ali, Gholam
   Gao, Yongqing
   Li, Jian
   Sun, Wenjie
   Li, Linlin
TI Cystatin C is Associated With Plaque Phenotype and Plaque Burden
SO KIDNEY & BLOOD PRESSURE RESEARCH
LA English
DT Article
DE Cystatin C; Plaque phenotype; Plaque burden; Renal function
ID GLOMERULAR-FILTRATION-RATE; CORONARY-HEART-DISEASE; CHRONIC
   KIDNEY-DISEASE; ACUTE MYOCARDIAL-INFARCTION; METABOLIC SYNDROME;
   SUBCLINICAL ATHEROSCLEROSIS; CARDIOVASCULAR MORBIDITY; SERUM CREATININE;
   BLOOD-PRESSURE; SHEAR-STRESS
AB Background/Aims: The relationship between carotid artery plaque burden, phenotype and serum cystatin C at normal and impaired renal function is still unclear. Methods: Demographic characteristics, carotid ultrasonography and other relevant information of 1,477 patients were collected. The association of carotid artery plaque burden, plaque phenotype with serum cystatin C was evaluated by strategy analysis based on renal function. Results: Serum cystatin C (OR=2.05, 95% CI: 1.83-2.29, P<.01) was a risk factor of stable plaque among patients with normal glomerular filtration rate. However, in the patients with mild impaired renal function, serum cystatin C was not only a risk factor for stable plaque (OR=1.60, 95% CI: 1.43-1.78, P<.001) but also was a risk factor for unstable plaque (OR=1.21, 95% CI: 1.10-1.32, P<.001). The smoothing function curve and a three-piecewise linear regression revealed that a nonlinear relationship was observed between serum cystatin C and plaque burden. When serum cystatin C was in the range of 0.75-1.30 (mg/L), the plaque burden tended to increase. Conclusion: In normal renal function, serum cystatin C may confer stability of plaques. In mildly impaired renal function, serum cystatin C is a risk predictor of plaques. In normal renal function circumstances, serum cystatin C may benefit to the stability of plaques. In mild impaired renal function circumstances, serum cystatin C are a risk predictors of plaques. (C) 2016 The Author(s) Published by S. Karger AG, Basel
C1 [Wen, Yufeng; Xia, Dan; Wang, Yanchun; Li, Haibo] Wannan Med Coll, Sch Publ Hlth, Wuhu, Anhui, Peoples R China.
   [Wang, Yanchun] Zhejiang Univ, Affiliated Hosp 4, Sch Med, Dept Pathol, Yiwu, Zhejiang, Peoples R China.
   [Zhang, Huiping] Maanshan Peoples Hosp, Dept Med Ultrason, Maanshan, Anhui, Peoples R China.
   [Ali, Gholam] Tulane Univ, Sch Med, 1430 Tulane Ave, New Orleans, LA 70112 USA.
   [Gao, Yongqing; Sun, Wenjie] Guangdong Pharmaceut Univ, Sch Food Sci, 9 Chang Ming Shui St, Zhongshan 528458, Peoples R China.
   [Li, Jian; Sun, Wenjie] Sch Publ Hlth & Trop Med, New Orleans, LA USA.
   [Li, Linlin] Calif Dept Publ Hlth, Sacramento, CA USA.
C3 Wannan Medical College; Zhejiang University; Tulane University;
   Guangdong Pharmaceutical University; California Department of Public
   Health
RP Sun, WJ (corresponding author), Guangdong Pharmaceut Univ, Sch Food Sci, 9 Chang Ming Shui St, Zhongshan 528458, Peoples R China.
EM wsun3@tulane.edu
RI Li, Linlin/AAE-6866-2021
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NR 45
TC 6
Z9 7
U1 0
U2 5
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1420-4096
EI 1423-0143
J9 KIDNEY BLOOD PRESS R
JI Kidney Blood Pressure Res.
PY 2016
VL 41
IS 2
BP 197
EP 207
DI 10.1159/000443422
PG 11
WC Physiology; Urology & Nephrology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology; Urology & Nephrology; Cardiovascular System & Cardiology
GA DI3DM
UT WOS:000373378500009
PM 27010456
OA gold
DA 2025-06-11
ER

PT J
AU Liu, SQ
   Hempe, JM
   McCarter, RJ
   Li, SX
   Fonseca, VA
AF Liu, Shuqian
   Hempe, James M.
   McCarter, Robert J.
   Li, Shengxu
   Fonseca, Vivian A.
TI Association between Inflammation and Biological Variation in Hemoglobin
   A1c in US Nondiabetic Adults
SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Article
ID CELL DISTRIBUTION WIDTH; C-REACTIVE PROTEIN; MEAN BLOOD-GLUCOSE;
   GLYCATED HEMOGLOBIN; OXIDATIVE STRESS; GLYCOSYLATED HEMOGLOBIN;
   CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; DIABETES-MELLITUS; FASTING
   INSULIN
AB Context: Inflammation is associated with higher glycated hemoglobin (HbA1c) levels. Whether the relationship is independent of blood glucose concentration remains unclear.
   Objective: The hemoglobin glycation index (HGI) was used to test the hypothesis that interindividual variation in HbA1c is associated with inflammation.
   Participants: This study used nondiabetic adults from the National Health and Nutrition Examination Survey (1999-2008).
   Main Outcome Measures: A subsample of participants was used to estimate the linear regression relationship between HbA1c and fasting plasma glucose (FPG). Predicted HbA1c were calculated for 7323 nondiabetic participants by inserting FPG into the equation, HbA1c = 0.017 x FPG (mg/dL) + 3.7. HGI was calculated as the difference between the observed and predicted HbA1c and the population was divided into low, moderate, and high HGI subgroups. Polymorphonuclear leukocytes (PMNL), monocytes, and C-reactive protein (CRP) were used as biomarkers of inflammation.
   Results: Mean HbA1c, CRP, monocyte, and PMNL levels, but not FPG, progressively increased in the low, moderate, and high HGI subgroups. There were disproportionately more Blacks than whites in the high HGI subgroup. CRP (beta, 0.009; 95% confidence interval [CI], 0.0001-0.017), PMNL (beta, 0.036; 95% CI, 0.010-0.062), and monocyte count (beta, 0.072; 95% CI, 0.041-0.104) were each independent predictors of HGI after adjustment for age, sex, race, triglycerides, hemoglobin level, mean corpuscular volume, red cell distribution width, and obesity status.
   Conclusions: HGI reflects the effects of inflammation on HbA1c in a nondiabetic population of U.S. adults and may be a marker of risk associated with inflammation independent of FPG, race, and obesity.
C1 [Liu, Shuqian; Fonseca, Vivian A.] Tulane Univ, Hlth Sci Ctr, Dept Med, New Orleans, LA 70112 USA.
   Tulane Univ, Dept Global Hlth Syst & Dev, Sch Publ Hlth & Trop Med, New Orleans, LA 70112 USA.
   [Hempe, James M.] Louisiana State Univ, Hlth Sci Ctr, Dept Pediat, New Orleans, LA 70118 USA.
   [Hempe, James M.] Childrens Hosp Res Inst Children, Res Inst Children, New Orleans, LA 70118 USA.
   [McCarter, Robert J.] Childrens Natl Med Ctr, Res Div Biostat & Study Methodol, Washington, DC 20010 USA.
   Tulane Univ, Dept Epidemiol, Sch Publ Hlth & Trop Med, New Orleans, LA 70112 USA.
C3 Tulane University; Tulane University; Louisiana State University System;
   Louisiana State University Health Sciences Center New Orleans;
   Children's Hospital of New Orleans; Children's National Health System;
   Tulane University
RP Fonseca, VA (corresponding author), Tulane Univ, Hlth Sci Ctr, Dept Med, 1430 Tulane Ave,SL 53, New Orleans, LA 70118 USA.
EM vfonseca@tulane.edu
RI Li, Shengxu/D-8915-2012
OI Hempe, James/0000-0001-7038-7499; Li, Shengxu/0000-0001-9210-7283
FU National Heart, Lung, And Blood Institute of the National Institutes of
   Health [R01HL110395]
FX This work was supported by National Heart, Lung, And Blood Institute of
   the National Institutes of Health under Award Number R01HL110395.
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NR 43
TC 74
Z9 78
U1 0
U2 8
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0021-972X
EI 1945-7197
J9 J CLIN ENDOCR METAB
JI J. Clin. Endocrinol. Metab.
PD JUN
PY 2015
VL 100
IS 6
BP 2364
EP 2371
DI 10.1210/jc.2014-4454
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA CQ8ET
UT WOS:000360840000050
PM 25867810
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Schwingshackl, L
   Hoffmann, G
AF Schwingshackl, L.
   Hoffmann, G.
TI Mediterranean dietary pattern, inflammation and endothelial function: A
   systematic review and meta-analysis of intervention trials
SO NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
LA English
DT Review
DE Mediterranean dietary pattern; Inflammation; Endothelial function;
   Meta-analysis
ID MONOUNSATURATED FATTY-ACIDS; FLOW-MEDIATED DILATION;
   CORONARY-HEART-DISEASE; CARDIOVASCULAR RISK-FACTORS; METABOLIC SYNDROME;
   OXIDATIVE STRESS; PLASMA-CONCENTRATIONS; INTERLEUKIN-6 LEVELS;
   GLUCOSE-METABOLISM; NORDIC DIET
AB Background: High adherence to a Mediterranean diet (MD) is associated with reduced all-cause and cardiovascular mortality risk. To our knowledge, there is no systematic review and meta-analysis of randomized controlled trials that has compared the effects of an MD on outcomes of endothelial function and inflammation.
   Methods and results: Literature search was performed using the electronic databases MEDLINE, EMBASE, and the Cochrane Trial Register. Inclusion criteria were: randomized controlled trials, 19 + years of age, and minimum intervention period of 12 weeks. Study specific weighted mean differences (WMD) were pooled using a random effect model. Seventeen trials including 2300 subjects met the objectives. MD regimens resulted in a significantly more pronounced increase in flow mediated dilatation [WMD: 1.86%, 95% CI 0.23 to 3.48, p = 0.02; I-2 = 43%], and adiponectin [WMD: 1.69 mu g/ml, 95% CI 0.27 to 3.11, p = 0.02; I-2 = 78%], while high-sensitive C reactive protein [WMD: -0.98 mg/l, 95% CI -1.48 to -0.49, p < 0.0001; I-2 = 91%], interleukin-6 [WMD: -0.42 pg/ml, 95% CI -0.73 to -0.11, p = 0.008; I-2 = 81%], and intracellular adhesion molecule-1 [WMD: -23.73 ng/ml, 95% CI -41.24 to -6.22 p = 0.008; I-2 = 34%] turned out to be significantly more decreased.
   Conclusion: The results of the present meta-analysis provide evidence that an MD decreases inflammation and improves endothelial function. (C) 2014 Elsevier B. V. All rights reserved.
C1 [Schwingshackl, L.; Hoffmann, G.] Univ Vienna, Fac Life Sci, Dept Nutr Sci, A-1090 Vienna, Austria.
C3 University of Vienna
RP Schwingshackl, L (corresponding author), Univ Vienna, Fac Life Sci, Dept Nutr Sci, Althanstr 14 UZA II, A-1090 Vienna, Austria.
EM lukas.schwingshackl@univie.ac.at
RI Schwingshackl, Lukas/AAC-4119-2019; Hoffmann, Georg/B-9201-2013;
   Schwingshackl, Lukas/B-9220-2013
OI Hoffmann, Georg/0009-0001-9890-9938; Schwingshackl,
   Lukas/0000-0003-3407-7594
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NR 67
TC 383
Z9 402
U1 0
U2 67
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0939-4753
EI 1590-3729
J9 NUTR METAB CARDIOVAS
JI Nutr. Metab. Carbiovasc. Dis.
PD SEP
PY 2014
VL 24
IS 9
BP 929
EP 939
DI 10.1016/j.numecd.2014.03.003
PG 11
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism; Nutrition
   & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism;
   Nutrition & Dietetics
GA AO4NB
UT WOS:000341315500001
PM 24787907
DA 2025-06-11
ER

PT J
AU Schwenger, KJP
   Allard, JP
AF Schwenger, Katherine J. P.
   Allard, Johane P.
TI Clinical approaches to non-alcoholic fatty liver disease
SO WORLD JOURNAL OF GASTROENTEROLOGY
LA English
DT Article
DE Non-alcoholic atty liver disease; Steatohepatitis; Cirrhosis; Steatosis;
   Pathogenesis; Diagnosis; Management; Treatment
ID LIFE-STYLE INTERVENTION; PLACEBO-CONTROLLED TRIAL; HEPATIC STEATOSIS;
   RISK-FACTORS; VITAMIN-E; STIFFNESS MEASUREMENT; FIBROSIS SCORE;
   NONINVASIVE ASSESSMENT; INSULIN-RESISTANCE; BARIATRIC SURGERY
AB Non-alcoholic fatty liver disease (NAFLD) ranges from simple steatosis to nonalcoholic steatohepatitis (NASH), leading to fibrosis and potentially cirrhosis, and it is one of the most common causes of liver disease worldwide. NAFLD is associated with other medical conditions such as metabolic syndrome, obesity, cardiovascular disease and diabetes. NASH can only be diagnosed through liver biopsy, but noninvasive techniques have been developed to identify patients who are most likely to have NASH or fibrosis, reducing the need for liver biopsy and risk to patients. Disease progression varies between individuals and is linked to a number of risk factors. Mechanisms involved in the pathogenesis are associated with diet and lifestyle, influx of free fatty acids to the liver from adipose tissue due to insulin resistance, hepatic oxidative stress, cytokines production, reduced very low-density lipoprotein secretion and intestinal microbiome. Weight loss through improved diet and increased physical activity has been the cornerstone therapy of NAFLD. Recent therapies such as pioglitazone and vitamin E have been shown to be beneficial. Omega 3 polyunsaturated fatty acids and statins may offer additional benefits. Bariatric surgery should be considered in morbidly obese patients. More research is needed to assess the impact of these treatments on a long-term basis. The objective of this article is to briefly review the diagnosis, management and treatment of this disease in order to aid clinicians in managing these patients. (C) 2014 Baishideng Publishing Group Co., Limited. All rights reserved.
C1 [Schwenger, Katherine J. P.] Univ Toronto, Inst Med Sci, Toronto, ON M5S 1A8, Canada.
   [Allard, Johane P.] Univ Hlth Network, Toronto Gen Hosp, Dept Med, Toronto, ON M5G 2C4, Canada.
C3 University of Toronto; University of Toronto; University Health Network
   Toronto; Toronto General Hospital
RP Allard, JP (corresponding author), Univ Hlth Network, Toronto Gen Hosp, Dept Med, 585 Univ Ave,Suite 9-N-973, Toronto, ON M5G 2C4, Canada.
EM johane.allard@uhn.on.ca
OI Schwenger, Katherine/0000-0002-7146-5505
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NR 115
TC 104
Z9 119
U1 0
U2 31
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 8226 REGENCY DR, PLEASANTON, CA 94588 USA
SN 1007-9327
EI 2219-2840
J9 WORLD J GASTROENTERO
JI World J. Gastroenterol.
PD FEB 21
PY 2014
VL 20
IS 7
BP 1712
EP 1723
DI 10.3748/wjg.v20.i7.1712
PG 12
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA AB7JO
UT WOS:000331966100008
PM 24587650
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Veldhorst, MAB
   Noppe, G
   Jongejan, MHTM
   Kok, CBM
   Mekic, S
   Koper, JW
   van Rossum, EFC
   van den Akker, ELT
AF Veldhorst, Margriet A. B.
   Noppe, Gerard
   Jongejan, Mieke H. T. M.
   Kok, Chantine B. M.
   Mekic, Selma
   Koper, Jan Willem
   van Rossum, Elisabeth F. C.
   van den Akker, Erica L. T.
TI Increased Scalp Hair Cortisol Concentrations in Obese Children
SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Article
ID PITUITARY-ADRENAL AXIS; LONG-TERM CORTISOL; METABOLIC SYNDROME; CHRONIC
   STRESS; OVERWEIGHT; CHILDHOOD; MARKER; MASS
AB Context: Pathologically increased cortisol exposure induces obesity, but it is not known whether relatively high cortisol within the physiological range is related to childhood obesity.
   Objective: The aim of the study was to compare hair cortisol concentrations between obese and normal-weight children.
   Design: We performed an observational case-control study.
   Participants: Twenty obese children (body mass index-SD score [BMI-SDS] > 2.3) and 20 age- and sex-matched normal-weight children (BMI-SDS < 1.1) aged 8-12 years were recruited.
   Main Outcome Measures: Scalp hair samples from the posterior vertex were collected, and hair cortisol concentrations were measured using ELISA. Body weight, height, and waist circumference were measured. From the obese children, additional data on blood pressure and blood lipid concentrations were collected.
   Results: In both groups, five boys and 15 girls were included; their mean age was 10.8 +/- 1.3 vs 10.8 +/- 1.2 years (obese vs normal weight; not significant). Body weight, BMI, BMI-SDS, and waist circumference were higher in the obese children compared with the normal-weight children (69.8 +/- 17.2 vs 35.5 +/- 7.2 kg; 29.6 +/- 4.9 vs 16.4 +/- 1.6 kg/m(2); 3.4 +/- 0.5 vs -0.2 +/- 0.8 SDS; 94 +/- 13 vs 62 +/- 6 cm; P < .001 all). Hair cortisol concentration was higher in obese than normal-weight children (median [interquartile range], 25 [17, 32] vs 17 [13, 21] pg/mg; P < .05).
   Conclusions: Hair cortisol concentration, a measure for long-term cortisol exposure, was higher in obese children than normal-weight children. This suggests long-term activation of the hypothalamus-pituitary-adrenal axis in obese children and may provide a novel target for treatment of obesity in children.
C1 [Veldhorst, Margriet A. B.; Noppe, Gerard; Kok, Chantine B. M.; Mekic, Selma; van den Akker, Erica L. T.] Sophia Childrens Univ Hosp, Erasmus MC, Dept Pediat, NL-3000 CB Rotterdam, Netherlands.
   [Veldhorst, Margriet A. B.] Acad Med Ctr Med Res BV, NL-1105 AZ Amsterdam, Netherlands.
   [Noppe, Gerard; Koper, Jan Willem; van Rossum, Elisabeth F. C.] Erasmus MC, Div Endocrinol, Dept Internal Med, NL-3015 CE Rotterdam, Netherlands.
   [Jongejan, Mieke H. T. M.] St Franciscus Gasthuis, Dept Pediat, NL-3045 PM Rotterdam, Netherlands.
   [Veldhorst, Margriet A. B.; Noppe, Gerard; Jongejan, Mieke H. T. M.; Kok, Chantine B. M.; Mekic, Selma; Koper, Jan Willem; van Rossum, Elisabeth F. C.; van den Akker, Erica L. T.] Erasmus MC, Obes Ctr CGG, NL-3015 CE Rotterdam, Netherlands.
   [Veldhorst, Margriet A. B.; Noppe, Gerard; Jongejan, Mieke H. T. M.; Kok, Chantine B. M.; Mekic, Selma; Koper, Jan Willem; van Rossum, Elisabeth F. C.; van den Akker, Erica L. T.] St Franciscus Gasthuis, NL-3015 CE Rotterdam, Netherlands.
C3 Erasmus University Rotterdam; Erasmus MC; Erasmus MC - Sophia Children's
   Hospital; Erasmus University Rotterdam; Erasmus MC; Franciscus Gasthuis;
   Erasmus University Rotterdam; Erasmus MC; Franciscus Gasthuis
RP van den Akker, ELT (corresponding author), Sophia Childrens Univ Hosp, Erasmus MC, Dept Pediat, POB 2060, NL-3000 CB Rotterdam, Netherlands.
EM e.l.t.vandenakker@erasmusmc.nl
RI van Rossum, Elisabeth/AAP-9388-2020; Akker, Erica/I-7624-2012
OI van Rossum, Elisabeth/0000-0003-0120-4913
FU Thrasher Research Fund [TRF11643]
FX This work was supported by a Thrasher Research Fund grant TRF11643.
CR Abraham SB, 2013, OBESITY, V21, pE105, DOI 10.1002/oby.20083
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NR 34
TC 95
Z9 104
U1 0
U2 32
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0021-972X
EI 1945-7197
J9 J CLIN ENDOCR METAB
JI J. Clin. Endocrinol. Metab.
PD JAN
PY 2014
VL 99
IS 1
BP 285
EP 290
DI 10.1210/jc.2013-2924
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA AD6WP
UT WOS:000333402200065
PM 24384019
DA 2025-06-11
ER

PT J
AU Szulinska, M
   Piorunek, T
   Suliburska, J
   Pupek-Musialik, D
   Kupsz, J
   Drzymala-Czyz, S
   Bogdanski, P
AF Szulinska, M.
   Piorunek, T.
   Suliburska, J.
   Pupek-Musialik, D.
   Kupsz, J.
   Drzymala-Czyz, S.
   Bogdanski, P.
TI Evaluation of insulin resistance, tumor necrosis factor alpha, and total
   antioxidant status in obese patients smoking cigarettes
SO EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
LA English
DT Article
DE Obesity; Smoking; Inflammation; Insulin resistance
ID METABOLIC SYNDROME; ADIPOSE-TISSUE; PLASMA-LEVELS; BODY-WEIGHT;
   TNF-ALPHA; RISK; POPULATION; FAT; ATHEROSCLEROSIS; TOLERANCE
AB INTRODUCTION AND BACKGROUND: Obesity and smoking are leading causes of morbidity and mortality worldwide. Cross-sectional studies indicate that heavy smoking may be associated with a greater risk of obesity. While there are important unresolved issues in relation to the effect of smoking on body weight, there is increasing evidence that smoking is conducive to a greater accumulation of visceral fat and greater insulin resistance.
   AIM: of this study was to determine the potential influences of obesity and smoking on tumor necrosis factor alpha (TNF-alpha), total antioxidant status (TAS), and insulin resistance.
   SUBJECTS AND METHODS: 30 obese nonsmokers, 30 obese smokers, 30 normal-weight smokers, and 30 healthy volunteers (the control) were studied. In all subjects, assessments of TNF-alpha, TAS, and insulin were made. Insulin resistance was evaluated according to the homeostasis model assessment-insulin resistance (HOMA-IR) protocol.
   RESULTS: TNF-alpha concentrations, as well as insulin resistance levels, in obese patients significantly exceeded those observed in the control. Compared to the control, obese patients presented significantly lower TAS levels. In the group of obese patients who actively smoked cigarettes, further increases in TNF-alpha and insulin resistance, as well as decreases in TAS level, were noticed. TNF-alpha concentration and insulin resistance levels were significantly higher, while TAS was lower in normal-weight smoking subjects, compared to the control. A positive correlation between TNF-alpha and HOMA-IR was found in the overall population.
   CONCLUSIONS: Obesity may evoke inflammatory processes, oxidative stress, and insulin resistance, all of which are aggravated by cigarette smoking. TNF-alpha should be considered in the complex pathogenesis of insulin resistance in obese patients who actively smoke.
C1 [Szulinska, M.; Pupek-Musialik, D.; Bogdanski, P.] Poznan Univ Med Sci, Dept Internal Med Metab Disorders & Hypertens, Poznan, Poland.
   [Piorunek, T.] Poznan Univ Med Sci, Dept Pulmonol Allergol & Resp Oncol 1, Poznan, Poland.
   [Suliburska, J.] Poznan Univ Life Sci, Dept Human Nutr & Hyg, Poznan, Poland.
   [Kupsz, J.] Poznan Univ Med Sci, Dept Physiol, Poznan, Poland.
   [Drzymala-Czyz, S.] Poznan Univ Med Sci, Dept Pediat Gastroenterol & Metab Dis, Poznan, Poland.
C3 Poznan University of Medical Sciences; Poznan University of Medical
   Sciences; Poznan University of Life Sciences; Poznan University of
   Medical Sciences; Poznan University of Medical Sciences
RP Bogdanski, P (corresponding author), Poznan Univ Med Sci, Dept Internal Med Metab Disorders & Hypertens, Poznan, Poland.
EM pawelbogdanski@wp.pl
RI Bogdański, Paweł/ABB-2938-2020; Szulińska, Monika/ABB-7157-2021
OI Bogdanski, Pawel/0000-0002-0563-1624; Suliburska,
   Joanna/0000-0002-0937-8427; szulinska, monika/0000-0002-1163-0919
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NR 43
TC 25
Z9 27
U1 0
U2 5
PU VERDUCI PUBLISHER
PI ROME
PA VIA GREGORIO VII, ROME, 186-00165, ITALY
SN 1128-3602
J9 EUR REV MED PHARMACO
JI Eur. Rev. Med. Pharmacol. Sci.
PD JUL
PY 2013
VL 17
IS 14
BP 1916
EP 1922
PG 7
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 228RC
UT WOS:000325203900013
PM 23877857
DA 2025-06-11
ER

PT J
AU de Kock, A
   Malan, L
   Hamer, M
   Malan, NT
AF de Kock, A.
   Malan, L.
   Hamer, M.
   Malan, N. T.
TI Defensive coping and subclinical vascular disease risk - Associations
   with autonomic exhaustion in Africans and Caucasians: The SABPA study
SO ATHEROSCLEROSIS
LA English
DT Article
DE Coping; Ethnicity; Norepinephrine metabolite; Subclinical vascular
   disease
ID PITUITARY-ADRENAL AXIS; METABOLIC SYNDROME; PHYSICAL-ACTIVITY; THICKNESS
AB Objective: The defensive active coping response is a recognised cardiovascular risk factor in Africans, especially in men. It is uncertain whether autonomic dysfunction might be the underlying cause. We therefore investigated associations between salivary MHPG (3-methoxy-4-hydroxyphenolglycol), as a marker of sympathetic activity, and subclinical vascular disease risk in defensive coping Africans and Caucasians.
   Methods: The Coping Strategy Indicator questionnaire identified participants who preferably utilise defensive coping. Ambulatory blood pressure was monitored for 24 h and carotid intima-media thickness (CIMT) was determined from ultrasound images, as an indicator of subclinical vascular disease risk. Salivary MHPG was analysed with high performance liquid chromatography.
   Results: Defensive active coping Africans (n = 143) showed overall poorer health than Caucasians (n = 148), with higher self-reported stress, alcohol abuse, hypertension, abdominal obesity, and risk of diabetes (p <= 0.05). African women demonstrated lower levels of MHPG compared with Caucasian women, although no differences in men were found. Furthermore, Africans revealed a trend of increased low grade inflammation and glycated haemoglobin which was associated with increased CIMT. There was an inverse association between MHPG and CIMT [beta = 0.22 ( 0.40, 0.03)], in African men with a high risk of subclinical vascular disease (n = 30).
   Conclusions: Novel findings revealed that defensive active coping Africans are more at risk of subclinical vascular disease, possibly resultant of autonomic exhaustion (decreased MHPG). When defensive coping fails, sympathetic hyperactivity may be followed by autonomic exhaustion and sympatho-adrenal-medullary system desensitisation, resulting in pathology. (c) 2012 Ireland Ltd. All rights reserved.
C1 [de Kock, A.; Malan, L.; Malan, N. T.] North West Univ, HART, Sch Physiol Nutr & Consumer Sci, ZA-2520 Potchefstroom, South Africa.
   [Hamer, M.] UCL, Dept Epidemiol & Publ Hlth, Psychobiol Grp, London WC1E 6BT, England.
C3 North West University - South Africa; University of London; University
   College London
RP Malan, L (corresponding author), North West Univ, HART, Sch Physiol Nutr & Consumer Sci, Potchefstroom Campus,Private Bag X6001, ZA-2520 Potchefstroom, South Africa.
EM 10060871@nwu.ac.za
RI Malan, Leone/Q-8187-2019; Hamer, Mark/C-1602-2008; Malan,
   Leone/D-7203-2014
OI Hamer, Mark/0000-0002-8726-7992; Malan, Leone/0000-0003-3187-2410
FU National Research Foundation; North-West University, Potchefstroom
   campus; Metabolic Syndrome Institute, France
FX The authors acknowledge all SABPA team members who assisted in the data
   sampling, and all the enthusiastic participants. Essential funding
   grants were attained from the National Research Foundation, the
   North-West University, Potchefstroom campus, and the Metabolic Syndrome
   Institute, France.
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NR 35
TC 14
Z9 14
U1 0
U2 4
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0021-9150
EI 1879-1484
J9 ATHEROSCLEROSIS
JI Atherosclerosis
PD DEC
PY 2012
VL 225
IS 2
BP 438
EP 443
DI 10.1016/j.atherosclerosis.2012.08.038
PG 6
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Cardiovascular System & Cardiology
GA 040SV
UT WOS:000311344700051
PM 23044096
DA 2025-06-11
ER

PT J
AU Polotsky, VY
   Patil, SP
   Savransky, V
   Laffan, A
   Fonti, S
   Frame, LA
   Steele, KE
   Schweizter, MA
   Clark, JM
   Torbenson, MS
   Schwartz, AR
AF Polotsky, Vsevolod Y.
   Patil, Susheel P.
   Savransky, Vladimir
   Laffan, Alison
   Fonti, Shannon
   Frame, Leigh A.
   Steele, Kimberly E.
   Schweizter, Michael A.
   Clark, Jeanne M.
   Torbenson, Michael S.
   Schwartz, Alan R.
TI Obstructive Sleep Apnea, Insulin Resistance, and Steatohepatitis in
   Severe Obesity
SO AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
LA English
DT Article
DE hypoxemia; fatty liver disease; metabolic syndrome; sleep-disordered
   breathing; liver injury
ID FATTY LIVER-DISEASE; CHRONIC INTERMITTENT HYPOXIA; C-REACTIVE PROTEIN;
   POSITIVE AIRWAY PRESSURE; SERUM AMINOTRANSFERASE LEVELS; NONALCOHOLIC
   STEATOHEPATITIS; WEIGHT-LOSS; CARDIOVASCULAR-DISEASE; BREATHING
   DISORDERS; BARIATRIC SURGERY
AB Rationale: Obstructive sleep apnea is associated with insulin resistance and liver injury. It is unknown whether apnea contributes to insulin resistance and steatohepatitis in severe obesity.
   Objectives: To examine whether sleep apnea and nocturnal hypoxemia predict the severity of insulin resistance, systemic inflammation, and steatohepatitis in severely obese individuals presenting for bariatric surgery.
   Methods: We performed sleep studies and measured fasting blood glucose, serum insulin, C-reactive protein, and liver enzymes in 90 consecutive severely obese individuals, 75 women and 15 men, without concomitant diabetes mellitus or preexistent diagnosis of sleep apnea or liver disease. Liver biopsies (n = 20) were obtained during bariatric surgery.
   Measurements and Main Results: Obstructive sleep apnea with a respiratory disturbance index greater than 5 events/hour was diagnosed in 81.1% of patients. The median respiratory disturbance index was 15 +/- 29 events/hour and the median oxygen desaturation during apneic events was 4.6 +/- 1.8%. All patients exhibited high serum levels of C-reactive protein, regardless of the severity of apnea, whereas liver enzymes were normal. Oxygen desaturation greater than 4.6% was associated with a 1.5-fold increase in insulin resistance, according to the homeostasis model assessment index. Histopathology data suggested that significant nocturnal desaturation might predispose to hepatic inflammation, hepatocyte ballooning, and liver fibrosis. Fasting blood glucose levels and steatosis scores were not affected by nocturnal hypoxia. There was no relationship between the respiratory disturbance index and insulin resistance or liver histopathology.
   Conclusions: Hypoxic stress of sleep apnea may be implicated in the development of insulin resistance and steatohepatitis in severe obesity.
C1 [Polotsky, Vsevolod Y.; Patil, Susheel P.; Savransky, Vladimir; Laffan, Alison; Fonti, Shannon; Frame, Leigh A.; Schwartz, Alan R.] Johns Hopkins Univ, Dept Med, Div Pulm & Crit Care Med, Baltimore, MD USA.
   [Steele, Kimberly E.; Schweizter, Michael A.] Johns Hopkins Univ, Dept Surg, Baltimore, MD USA.
   [Clark, Jeanne M.] Johns Hopkins Univ, Dept Med, Div Gen Internal Med, Baltimore, MD USA.
   [Clark, Jeanne M.] Johns Hopkins Univ, Dept Epidemiol, Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD USA.
   [Torbenson, Michael S.] Johns Hopkins Univ, Dept Pathol, Baltimore, MD USA.
C3 Johns Hopkins University; Johns Hopkins University; Johns Hopkins
   University; Johns Hopkins University; Johns Hopkins Bloomberg School of
   Public Health; Johns Hopkins University
RP Polotsky, VY (corresponding author), Johns Hopkins Asthma & Allergy Ctr, 5501 Hopkins Bayview Circle, Baltimore, MD 21224 USA.
EM vpolots1@jhmi.edu
RI Patil, Susheel/K-2554-2019; Clark, Jeanne/AGG-8199-2022; Laffan,
   Alison/HJY-7709-2023; Frame, Leigh/L-3104-2016
OI Clark, Jeanne/0000-0003-1194-0092; Patil, Susheel/0000-0001-6501-5957;
   Frame, Leigh/0000-0002-1475-2778
FU NHLBI NIH HHS [R01 HL080105] Funding Source: Medline
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NR 50
TC 149
Z9 158
U1 0
U2 8
PU AMER THORACIC SOC
PI NEW YORK
PA 25 BROADWAY, 18 FL, NEW YORK, NY 10004 USA
SN 1073-449X
EI 1535-4970
J9 AM J RESP CRIT CARE
JI Am. J. Respir. Crit. Care Med.
PD FEB 1
PY 2009
VL 179
IS 3
BP 228
EP 234
DI 10.1164/rccm.200804-608OC
PG 7
WC Critical Care Medicine; Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Respiratory System
GA 398ML
UT WOS:000262736100008
PM 18990675
OA Green Published
DA 2025-06-11
ER

PT J
AU Zaiou, M
   Joubert, O
AF Zaiou, Mohamed
   Joubert, Olivier
TI Racial and Ethnic Disparities in NAFLD: Harnessing Epigenetic and Gut
   Microbiota Pathways for Targeted Therapeutic Approaches
SO BIOMOLECULES
LA English
DT Review
DE NAFLD; health disparities; epigenetics; DNA methylation; MASLD;
   dysbiosis
ID FATTY LIVER-DISEASE; NONALCOHOLIC STEATOHEPATITIS; HEPATIC STEATOSIS;
   INSULIN SENSITIVITY; PREVALENCE; SIRT1; TRANSPLANTATION; EPIDEMIOLOGY;
   RESVERATROL; ASSOCIATION
AB Nonalcoholic fatty liver disease (NAFLD) is a growing global health concern, impacting approximately 32.4% of the worldwide population. As a disease linked to metabolic dysfunction, NAFLD continues to rise alongside global increases in obesity, type 2 diabetes mellitus (T2DM), and metabolic syndrome. There is considerable evidence indicating that NAFLD disproportionately affects racial, ethnic, and minority groups, although the exact reasons for these disparities remain elusive. Contributing factors to this disease may include socioeconomic status, cultural influences, stress, genetic factors, and lifestyle choices. Emerging evidence suggests that these causal factors could influence epigenetic mechanisms, particularly DNA methylation and histone modifications, as well as the composition and diversity of gut microbiota. Nevertheless, there is a scarcity of research that comprehensively examines the interplay between epigenetic changes and gut microbiome variations in relation to NAFLD disparities across different racial and ethnic populations globally. This paper intends to (i) explore the connections between NAFLD, ethnic disparities, gut microbiota composition, and epigenetic alterations, while reviewing pertinent studies that illustrate how these factors contribute to health inequities among various ethnic groups impacted by this disease; (ii) explore potential therapeutic targets and biomarkers to advance the management of NAFLD; and (iii) provide insights to enhance our understanding of the mechanisms associated with this disease, thereby promoting further research in this field. Advancements in this area are anticipated to enhance our understanding of disease susceptibilities in at-risk groups and to provide new therapeutic options for NAFLD and its associated complications.
C1 [Zaiou, Mohamed; Joubert, Olivier] Univ Lorraine, CNRS, IJL, F-54000 Nancy, France.
C3 Centre National de la Recherche Scientifique (CNRS); Universite de
   Lorraine
RP Zaiou, M (corresponding author), Univ Lorraine, CNRS, IJL, F-54000 Nancy, France.
EM mohamed.zaiou@univ-lorraine.fr; olivier.joubert@univ-lorraine.fr
RI joubert, Olivier/A-7713-2015
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NR 157
TC 0
Z9 0
U1 0
U2 0
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2218-273X
J9 BIOMOLECULES
JI Biomolecules
PD MAY 5
PY 2025
VL 15
IS 5
AR 669
DI 10.3390/biom15050669
PG 24
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 3DL1L
UT WOS:001497698900001
PM 40427561
DA 2025-06-11
ER

PT J
AU Kumar, KSP
   Jyothi, MN
   Prashant, A
AF Kumar, K. S. Praveen
   Jyothi, M. N.
   Prashant, Akila
TI Mitochondrial DNA variants in the pathogenesis and metabolic alterations
   of diabetes mellitus
SO MOLECULAR GENETICS AND METABOLISM REPORTS
LA English
DT Article
DE Mitochondrial DNA; ATP production; Genetic variation; Biomarkers;
   Metabolic disorder
ID DYSFUNCTION; MUTATION; INSULIN; CARDIOMYOCYTES; PHYSIOLOGY; DEFECTS;
   GENES
AB Mitochondrial DNA (mtDNA) variants considerably affect diabetes mellitus by disturbing mitochondrial function, energy metabolism, oxidative stress response, and even insulin secretion. The m.3243 A > G variants is associated with maternally inherited diabetes and deafness (MIDD), where early onset diabetes and hearing loss are prominent features. Other types of mtDNA variants involve genes ND4 and tRNA Ala genes that increase susceptibility to type 2 diabetes. Understanding these variants will provide a basis for developing targeted therapy to improve mitochondrial function and metabolic health. This article reviews the impact of mtDNA variants in diabetes, specifically with regards to the m.3243 A > G variant effects on mitochondrial function and insulin secretion and other mtDNA variants that contribute to diabetes susceptibility, particularly ND4 and tRNA Ala gene variants. Data from extant literature were synthesised to obtain an understanding of how mtDNA variants affect diabetes pathogenesis. The main defect for MIDD is the m.3243 A > G variant, which comprises enhanced susceptibility to metabolic syndrome and type 2 diabetes, followed by mitochondrial dysfunction, insulin resistance, and beta-cell dysfunction. Other mtDNA variants have also been reported to enhance diabetes susceptibility through mitochondrial dysfunction and insulin resistance. Increased production of reactive oxygen species (ROS) resulting from mitochondrial malfunction adds to metabolic and tissue damage. This happens in tissues crucial to glucose homeostasis, and it represents an important contribution of mitochondrial dysfunction to metabolic disturbances in diabetes. These mechanisms would underlie the rationale for developing targeted therapies to preserve mitochondrial function and, hence improve the metabolic health of diabetic patients.
C1 [Kumar, K. S. Praveen; Jyothi, M. N.] JSS AHER, JSS Med Coll & Hosp, Dept Med Genet, Mysuru 570015, India.
   [Prashant, Akila] JSS AHER, Dept Biochem, JSS Med Coll & Hosp, Mysuru 570015, India.
   [Kumar, K. S. Praveen; Prashant, Akila] JSS AHER, JSS Med Coll & Hosp, SIG TRRG, Mysuru 570015, India.
C3 JSS Academy of Higher Education & Research; JSS Medical College, Mysuru;
   JSS Academy of Higher Education & Research; JSS Medical College, Mysuru;
   JSS Academy of Higher Education & Research; JSS Medical College, Mysuru
RP Kumar, KSP (corresponding author), JSS AHER, JSS Med Coll & Hosp, Dept Med Genet, Mysuru 570015, India.
RI Prashant, Akila/AAI-4468-2020; Narahari, Jyothi/JEZ-8911-2023; Kumar K.
   S., Praveen/JCD-7945-2023
OI Kumar K S, Praveen/0000-0003-3754-1401
FU JSS Medical College and Hospitals, JSS Academy of Higher Education and
   Research (JSS-AHER), Mysuru
FX We acknowledge JSS Medical College and Hospitals, JSS Academy of Higher
   Education and Research (JSS-AHER), Mysuru for the valuable support.
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NR 134
TC 0
Z9 0
U1 6
U2 6
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
EI 2214-4269
J9 MOL GENET METAB REP
JI Molec. Genet. Metab. Rep.
PD MAR
PY 2025
VL 42
AR 101183
DI 10.1016/j.ymgmr.2024.101183
PG 15
WC Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Genetics & Heredity
GA T3P5K
UT WOS:001404169700001
PM 39835172
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Wang, LF
   Bai, X
   Zhao, LM
   Li, XD
   Mu, FX
   Liu, CY
   Xie, Q
AF Wang, Lifang
   Bai, Xue
   Zhao, Limei
   Li, Xiaodong
   Mu, Fangxiang
   Liu, Chunyan
   Xie, Qiong
TI Association between serum unsaturated fatty acids levels and infertility
   among American women from the National Health and Nutrition Examination
   Survey 2013-2014
SO LIPIDS IN HEALTH AND DISEASE
LA English
DT Article
DE Unsaturated fatty acids; Infertility; Palmitoleic acid; Oleic acid;
   Metabolic syndrome
ID OOCYTE MATURATION; QUALITY; STRESS; DIET
AB Background Some research indicates that unsaturated fatty acids (UFAs) in the diet could enhance reproductive outcomes in infertile women. However, other research holds different views, possibly due to differences in the conversion rates of UFAs from various foods and bioavailability in the body. Therefore, this research examined the link between serum UFAs and infertility issues. Methods This research included reproductive-age women participating in the 2013-2014 American National Health and Nutrition Examination Survey (NHANES). Serum levels of four UFAs, including palmitoleic acid (16:1n-7), vaccenic acid (18:1n-7), oleic acid (18:1n-9), and linoleic acid (18:2n-6) were measured through gas chromatography-mass spectrometry. Infertility data was collected by affirmative responses to targeted questionnaire items. Associations between serum UFA levels and infertility were evaluated utilizing Poisson regression models and smooth curve fitting methods. Sensitivity analysis was also conducted. Results This study included 535 women, aged between 18 and 45. Poisson regression analysis, both adjusted and unadjusted for confounders, revealed no associations between palmitoleic acid, vaccenic acid, oleic acid, or linoleic acid and female infertility (all P > 0.05). However, four UFAs all showed non-linear relationships with infertility in smooth curve fitting analysis. Sensitivity analysis confirmed the stability of the findings. Conclusion This research established non-linear associations between serum UFAs and infertility in American women. Specifically, maintaining appropriate serum levels of these UFAs may lower infertility risk. These findings offer new insights and practical dietary recommendations for improving female fertility.
C1 [Wang, Lifang; Bai, Xue; Zhao, Limei; Li, Xiaodong; Liu, Chunyan; Xie, Qiong] First Peoples Hosp, Dept Gynecol, Chongqing Liang Jiang New Area, 199 Renxing Rd,Renhe St, Chongqing 401121, Peoples R China.
   [Mu, Fangxiang] Lanzhou Univ Second Hosp, Dept Reprod Med, Lanzhou 730030, Peoples R China.
RP Liu, CY; Xie, Q (corresponding author), First Peoples Hosp, Dept Gynecol, Chongqing Liang Jiang New Area, 199 Renxing Rd,Renhe St, Chongqing 401121, Peoples R China.
EM liuchunyan8060@163.com; xieqiong3765@163.com
RI Liu, Chunyan/KGM-3639-2024
FU Clinical study of transvaginal double independent sling reconstruction
   in patients with mid-pelvic organ prolapse
FX We are thankful to the NHANES participants and staff for their
   contributions.
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NR 48
TC 0
Z9 0
U1 4
U2 4
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1476-511X
J9 LIPIDS HEALTH DIS
JI Lipids Health Dis.
PD NOV 15
PY 2024
VL 23
IS 1
AR 377
DI 10.1186/s12944-024-02366-9
PG 9
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA M2I8K
UT WOS:001355834900002
PM 39543680
OA gold, Green Accepted
DA 2025-06-11
ER

PT J
AU Lee, SB
   Jin, MH
   Yoon, JH
AF Lee, Su-bin
   Jin, Mi Hyeon
   Yoon, Jeong-Hyun
TI The contribution of vitamin D insufficiency to the onset of steatotic
   liver disease among individuals with metabolic dysfunction
SO SCIENTIFIC REPORTS
LA English
DT Article
DE Hepatic steatosis; Metabolic syndrome; Metabolic associated fatty liver
   disease; Vitamin D insufficiency
ID OXIDATIVE STRESS; ASSOCIATION; INFLAMMATION; SEVERITY; RECEPTOR; RISK;
   FAT
AB The interplay between fatty liver disease (FLD) and metabolic dysfunction has given rise to the concept of metabolic associated fatty liver disease (MAFLD). With vitamin D insufficiency frequently co-occurring with FLD and linked to metabolic abnormalities, this study investigates the potential role of vitamin D in the development of MAFLD. In this cross-sectional analysis, 22,476 participants with baseline metabolic dysfunction and known serum 25-OH-vitamin D3 levels were examined. The fatty liver index (FLI) was utilized to predict FLD, dividing subjects into MAFLD and non-MAFLD groups. Further stratification by vitamin D levels (sufficient vs. insufficient) and gender provided a detailed assessment through binary logistic regression to determine the association of vitamin D status with MAFLD incidence. Vitamin D insufficiency correlated with a higher MAFLD incidence in metabolically impaired individuals. Post-adjustment, the correlation was stronger (men: aOR = 1.32, 95% CI = 1.22-1.43, P < 0.001; women: aOR = 1.53, 95% CI = 1.18-1.98, P = 0.001). Lower serum 25-OH-vitamin D3 levels were found in MAFLD patients across genders (men: P = 0.003; women: P = 0.014), with a higher prevalence of insufficiency in MAFLD cases (men: P = 0.007; women: P = 0.003). The vitamin D-MAFLD link was stable across subgroups and using varying FLI criteria. Our findings indicate a clear association between vitamin D insufficiency and increased MAFLD incidence, underscoring the potential of vitamin D as an anti-lipogenic and anti-fibrotic agent.
C1 [Lee, Su-bin] Sungkyunkwan Univ, Samsung Changwon Hosp, Sch Med, Dept Pharm, Chang Won, South Korea.
   [Jin, Mi Hyeon] Sungkyunkwan Univ, Samsung Changwon Hosp, Sch Med, Dept Res Support, Chang Won, South Korea.
   [Yoon, Jeong-Hyun] Pusan Natl Univ, Coll Pharm, 2 Busandaehak Ro,63 Beon Gil, Busan 46241, South Korea.
   [Yoon, Jeong-Hyun] Pusan Natl Univ, Res Inst Drug Dev, 2 Busandaehak Ro,63 Beon Gil, Busan 46241, South Korea.
C3 Sungkyunkwan University (SKKU); Samsung Medical Center; Sungkyunkwan
   University (SKKU); Samsung Medical Center; Pusan National University;
   Pusan National University
RP Yoon, JH (corresponding author), Pusan Natl Univ, Coll Pharm, 2 Busandaehak Ro,63 Beon Gil, Busan 46241, South Korea.; Yoon, JH (corresponding author), Pusan Natl Univ, Res Inst Drug Dev, 2 Busandaehak Ro,63 Beon Gil, Busan 46241, South Korea.
EM jyoon@pusan.ac.kr
RI Lee, Subin/ABC-3556-2020
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NR 39
TC 5
Z9 5
U1 2
U2 2
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD MAR 20
PY 2024
VL 14
IS 1
AR 6714
DI 10.1038/s41598-024-57380-9
PG 12
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA MG4I1
UT WOS:001192455600002
PM 38509247
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Dehzad, MJ
   Ghalandari, H
   Nouri, M
   Askarpour, M
AF Dehzad, Mohammad Jafar
   Ghalandari, Hamid
   Nouri, Mehran
   Askarpour, Moein
TI Effects of curcumin/turmeric supplementation on glycemic indices in
   adults: A grade-assessed systematic review and dose-response
   meta-analysis of randomized controlled trials
SO DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS
LA English
DT Review
DE Glycemic profile; Randomized controlled trials (RCTs); Meta-analysis;
   Curcumin/turmeric
ID FATTY LIVER-DISEASE; TYPE-2 DIABETES-MELLITUS; NANO-CURCUMIN
   SUPPLEMENTATION; CHRONIC KIDNEY-DISEASE; INDUCED MUSCLE DAMAGE;
   DOUBLE-BLIND; METABOLIC SYNDROME; TURMERIC SUPPLEMENTATION; OXIDATIVE
   STRESS; LIPID PROFILE
AB Introduction: Glycemic control is of utmost importance both as a preventive measure in individuals at risk of diabetes and in the management of patients with disturbed glycemia. Turmeric/curcumin has been extensively studied in this field. In the present systematic review and meta-analysis, we aimed at investigating the impact of turmeric/curcumin supplementation on glycemic control. Methods: Major online databases (PubMed, Scopus, Web of Science, Cochrane Library and Google Scholar) were systematically searched from inception up to October 2022. Relevant randomized controlled trials (RCTs) meeting our eligible criteria were included. Weighted mean differences (WMDs) with confidence intervals (CIs) were expressed using a random-effect model. Subgroup analyses were conducted to find the sources of hetero-geneities. To detect risk of bias in the included studies, we used the Cochrane risk-of-bias tool. The registration number was CRD42022374874. Results: Out of 4182 articles retrieved from the initial search, 59 RCTs were included. Our findings suggested that turmeric/curcumin supplementation was significantly effective in improving fasting blood sugar (WMD: 4.60 mg/dl; 95% CI: 5.55,-3.66), fasting insulin levels (WMD: 0.87 mu IU/ml; 95% CI: 1.46,-0.27), hemoglobin A1c (HbA1c) (WMD: 0.32%; 95% CI: 0.45,-0.19), and homeostatic model assessment of insulin resistance (HOMA -IR) (WMD: 0.33; 95% CI: 0.43,-0.22). Conclusion: Our results indicate that turmeric/curcumin supplementation can be considered as a complementary method in the management of disturbed glycemia.
C1 [Dehzad, Mohammad Jafar; Askarpour, Moein] Shiraz Univ Med Sci, Sch Nutr Sci & Dietet, Dept Clin Nutr, Shiraz, Iran.
   [Ghalandari, Hamid; Nouri, Mehran] Shiraz Univ Med Sci, Sch Nutr Sci & Dietet, Dept Commun Nutr, Shiraz, Iran.
   [Dehzad, Mohammad Jafar; Ghalandari, Hamid; Nouri, Mehran; Askarpour, Moein] Shiraz Univ Med Sci, Students Res Comm, Sch Nutr & Food Sci, Shiraz, Iran.
   [Askarpour, Moein] Shiraz Univ Med Sci, Sch Nutr Sci & Dietet, Dept Clin Nutr, Shiraz 71536, Iran.
C3 Shiraz University of Medical Science; Shiraz University of Medical
   Science; Shiraz University of Medical Science; Shiraz University of
   Medical Science
RP Askarpour, M (corresponding author), Shiraz Univ Med Sci, Sch Nutr Sci & Dietet, Dept Clin Nutr, Shiraz 71536, Iran.
EM askarpourmoein1994@gmail.com
OI Dehzad, Mohammad Jafar/0000-0002-1596-5791
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NR 154
TC 2
Z9 2
U1 0
U2 1
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 1871-4021
EI 1878-0334
J9 DIAB MET SYND CLIN R
JI DIABET. METAB. SYNDR. CLIN. RES. REV.
PD OCT
PY 2023
VL 17
IS 10
AR 102855
DI 10.1016/j.dsx.2023.102855
EA SEP 2023
PG 17
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA EH4X0
UT WOS:001138028500001
PM 37748368
DA 2025-06-11
ER

PT J
AU Sucato, V
   Coppola, G
   Manno, G
   Vadalà, G
   Novo, G
   Corrado, E
   Galassi, AR
AF Sucato, Vincenzo
   Coppola, Giuseppe
   Manno, Girolamo
   Vadala, Giuseppe
   Novo, Giuseppina
   Corrado, Egle
   Galassi, Alfredo Ruggero
TI Coronary Artery Disease in South Asian Patients: Cardiovascular Risk
   Factors, Pathogenesis and Treatments
SO CURRENT PROBLEMS IN CARDIOLOGY
LA English
DT Review
ID MYOCARDIAL-INFARCTION; METABOLIC SYNDROME; HIGH PREVALENCE;
   HEART-DISEASE; ETHNIC-GROUPS; INDIVIDUALS; TICAGRELOR; INDIANS; IMPACT;
   ASSOCIATION
AB In the last decades a significant increase of the migratory phenomenon from South Asian coun-tries to the Western World has occurred for social, economic and geopolitical reasons. The aim of this review is to describe cardiovascular risk factors, path-ogenesis and treatments of coronary artery disease in South Asian patients. It is well established that South Asian populations have a higher prevalence of coro-nary artery disease and premature onset of myocardial infarction episodes than other populations. This higher predisposition might be caused by genetic factors, common in both South Asian patients residing in their birth country and in those residing abroad, but it may also be due to the new spatial environment in which they live. It will be important to examine the leading cardiovascular risk factors determining increasing incidence of coronary artery disease in the South Asian population. These include: insulin resistance, hyper-tension, dyslipidaemia and abdominal obesity caused by a diet rich in refined carbohydrates and saturated fats. Furthermore, it is important to examine emerging cardiovascular risk factors strictly related to this par-ticular ethnic group. The evidence of higher levels of prothrombotic and proinflammatory factors, for example lipoprotein(a) and proinflammatory adipo-kines, as well as the influence of air pollution and psy-chosocial stress, may have consequences on the risk, treatment and outcomes of the coronary artery disease in this population. Migrants from South Asia deserve to be addressed and framed with particular care in terms of cardiovascular risk and especially in the man-agement of acute coronary events
C1 [Sucato, Vincenzo; Coppola, Giuseppe; Manno, Girolamo; Novo, Giuseppina; Corrado, Egle; Galassi, Alfredo Ruggero] Univ Palermo, Dept Hlth Promot Mother & Child Care Internal Med, Palermo, Italy.
   [Sucato, Vincenzo; Coppola, Giuseppe; Vadala, Giuseppe; Novo, Giuseppina; Corrado, Egle] Univ Hosp Paolo Giaccone, Div Cardiol, Palermo, Italy.
C3 University of Palermo; University of Palermo; Policlinico Paolo Giaccone
RP Sucato, V (corresponding author), Univ Palermo, Dept Hlth Promot Mother & Child Care Internal Med, Palermo, Italy.; Sucato, V (corresponding author), Univ Hosp Paolo Giaccone, Div Cardiol, Palermo, Italy.
RI Galassi, Andrea/AAC-4273-2022; novo, giuseppina/K-6580-2016; Sucato,
   Vincenzo/AAB-7272-2022; Vadalà, Giuseppe/AAB-8157-2022
OI Sucato, Vincenzo/0000-0001-9514-1575; Galassi,
   Alfredo/0000-0002-9366-2251; Vadala, Giuseppe/0000-0003-0869-4855
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NR 45
TC 23
Z9 23
U1 0
U2 7
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0146-2806
EI 1535-6280
J9 CURR PROB CARDIOLOGY
JI Curr. Probl. Cardiol.
PD AUG
PY 2023
VL 48
IS 8
AR 101228
DI 10.1016/j.cpcardiol.2022.101228
EA JUN 2023
PG 17
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA L3SY9
UT WOS:001022503200001
PM 35500733
DA 2025-06-11
ER

PT J
AU Pedersen, K
   Ipsen, DH
   Skat-Rordam, J
   Lykkesfeldt, J
   Tveden-Nyborg, P
AF Pedersen, Kamilla
   Ipsen, David Hojland
   Skat-Rordam, Josephine
   Lykkesfeldt, Jens
   Tveden-Nyborg, Pernille
TI Dietary Long-Chain Fatty Acids Accelerate Metabolic Dysfunction in
   Guinea Pigs with Non-Alcoholic Steatohepatitis
SO NUTRIENTS
LA English
DT Article
DE non-alcoholic fatty liver disease (NAFLD); non-alcoholic steatohepatitis
   (NASH); medium-chain fatty acid; long-chain fatty acid; glucose
   intolerance; uric acid; guinea pigs
ID LIVER-DISEASE; OXIDATIVE STRESS; ENERGY-EXPENDITURE; HEPATIC STEATOSIS;
   DEHYDROASCORBIC ACID; INSULIN-RESISTANCE; SKELETAL-MUSCLE; SCORING
   SYSTEM; VITAMIN-C; TRIGLYCERIDES
AB The composition of dietary fatty acids may be important for the development and progression of metabolic syndrome and non-alcoholic steatohepatitis (NASH). This study investigated the effect of two high-fat diets based on coconut oil, containing predominantly medium-chain fatty acids (MCFA), or cocoa butter, containing mainly long-chain fatty acids (LCFA), on glucose homeostasis and NASH in guinea pigs following 16 and 32 weeks of diet. At week 16, glucose intolerance was increased in the LCFA animals compared to the MCFA animals (p < 0.001), with both groups differing from the controls by week 32 (p < 0.0001), supported by increased hemoglobin A1c (p < 0.05). NASH was present in both high-fat groups from week 16, with advancing fibrosis appearing more progressive in the LCFA animals at week 16. In agreement, gene expression showed overall increased expression of NASH target genes in the LCFA animals compared to the MCFA animals at weeks 16 and 32 (p < 0.05 and p < 0.0001, respectively). The LCFA animals also displayed increased plasma uric acid at both time points (p < 0.05), a phenomenon linked to NASH in humans. In conclusion, this study reports that a diet high in LCFA promotes metabolic imbalance and may accelerate NASH-associated hepatic fibrosis. This highlights the importance of a critical evaluation of fatty acid composition when investigating NASH-associated endpoints.
C1 [Pedersen, Kamilla; Ipsen, David Hojland; Skat-Rordam, Josephine; Lykkesfeldt, Jens; Tveden-Nyborg, Pernille] Univ Copenhagen, Fac Hlth & Med Sci, Dept Vet & Anim Sci, Sect Expt Anim Models, DK-1870 Frederiksberg, Denmark.
   [Ipsen, David Hojland] Novo Nord AS, Obes, Integrated Physiol Res, DK-2760 Malov, Denmark.
   [Ipsen, David Hojland] Novo Nord AS, NASH Pharmacol, DK-2760 Malov, Denmark.
C3 University of Copenhagen; Novo Nordisk; Novo Nordisk
RP Tveden-Nyborg, P (corresponding author), Univ Copenhagen, Fac Hlth & Med Sci, Dept Vet & Anim Sci, Sect Expt Anim Models, DK-1870 Frederiksberg, Denmark.
EM kamilla.pedersen@sund.ku.dk; dvie@novonordisk.com; jsr@sund.ku.dk;
   jopl@sund.ku.dk; ptn@sund.ku.dk
RI ; Lykkesfeldt, Jens/A-1072-2011
OI Ipsen, David/0000-0002-2065-8497; Tveden-Nyborg,
   Pernille/0000-0002-5574-5742; Pedersen, Kamilla/0000-0003-2852-2882;
   Lykkesfeldt, Jens/0000-0002-6514-8407; Skat-Rordam,
   Josephine/0000-0002-8160-9330
FU LifePharm Centre for in vivo pharmacology [1001109652]
FX This research was partly funded by the LifePharm Centre for in vivo
   pharmacology (Grant number #1001109652).
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TC 4
Z9 4
U1 0
U2 9
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD MAY 24
PY 2023
VL 15
IS 11
AR 2445
DI 10.3390/nu15112445
PG 20
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA I6OL6
UT WOS:001003956900001
PM 37299406
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Barber, TM
   Kabisch, S
   Pfeiffer, AFH
   Weickert, MO
AF Barber, Thomas M.
   Kabisch, Stefan
   Pfeiffer, Andreas F. H.
   Weickert, Martin O.
TI The Effects of the Mediterranean Diet on Health and Gut Microbiota
SO NUTRIENTS
LA English
DT Review
DE Mediterranean diet; gut microbiota; dietary fibre; monounsaturated fat
ID LOW-FAT DIETS; CEREAL-FIBER; INSULIN SENSITIVITY; RISK-FACTORS;
   SECONDARY PREVENTION; OXIDATIVE STRESS; PREDIMED TRIAL; OLIVE OIL;
   METAANALYSIS; POLYPHENOLS
AB The Mediterranean Diet (MD) is plant-based and consists of multiple daily portions of vegetables, fruit, cereals, and olive oil. Although there are challenges with isolating the MD from the typical Mediterranean lifestyle and culture (including prolonged 'social' meals and siestas), much evidence supports the health benefits of the MD that include improved longevity, reduced metabolic risk of Diabetes Mellitus, obesity, and Metabolic Syndrome, reduced risk of malignancy and cardiovascular disease, and improved cognitive function. The MD is also associated with characteristic modifications to gut microbiota, mediated through its constituent parts (primarily dietary fibres, extra virgin olive oil, and polyunsaturated fatty acids [including ?-3]). These include enhanced growth of species that produce short-chain fatty acids (butyrate), such as Clostridium leptum and Eubacterium rectale, enhanced growth of Bifidobacteria, Bacteroides, and Faecalibacterium prausnitzii species, and reduced growth of Firmicutes and Blautia species. Such changes in gut microbiota are known to be associated favourably with inflammatory and oxidative status, propensity for malignancy and overall metabolic health. A key challenge for the future is to explore the extent to which the health benefits of the MD are mediated by such changes to gut microbiota. The MD confers both health and environmental benefits. Adoption of the MD should perhaps be encouraged and facilitated more generally and not just restricted to populations from Mediterranean regions. However, there are key challenges to this approach that include limited perennial availability of the constituent parts of the MD in some non-Mediterranean regions, intolerability of a high-fibre diet for some people, and potential cultural disconnects that juxtapose some traditional (including Western) diets with the MD.
C1 [Barber, Thomas M.; Weickert, Martin O.] Univ Hosp Coventry & Warwickshire, Warwickshire Inst Study Diabet Endocrinol & Metab, Clifford Bridge Rd, Coventry CV2 2DX, England.
   [Barber, Thomas M.; Weickert, Martin O.] Univ Warwick, Warwick Med Sch, Div Biomed Sci, Coventry CV2 2DX, England.
   [Barber, Thomas M.; Weickert, Martin O.] Univ Hosp Coventry & Warwickshire, NIHR CRF Human Metab Res Unit, Clifford Bridge Rd, Coventry CV2 2DX, England.
   [Kabisch, Stefan; Pfeiffer, Andreas F. H.] Charite, Dept Endocrinol Diabet & Nutr, Campus Benjamin Franklin,Hindenburgdamm 30, D-12203 Berlin, Germany.
   [Kabisch, Stefan; Pfeiffer, Andreas F. H.] Geschaftsstelle Helmholtz Zentrum Munchen, Deutsch Zentrum Diabetesforsch eV, Ingolstadter Landstr, D-85764 Neuherberg, Germany.
   [Weickert, Martin O.] Coventry Univ, Fac Hlth & Life Sci, Ctr Sport Exercise & Life Sci, Coventry CV2 2DX, England.
C3 University of Warwick; University of Warwick; University of Warwick;
   Berlin Institute of Health; Free University of Berlin; Humboldt
   University of Berlin; Charite Universitatsmedizin Berlin; Coventry
   University
RP Weickert, MO (corresponding author), Univ Hosp Coventry & Warwickshire, Warwickshire Inst Study Diabet Endocrinol & Metab, Clifford Bridge Rd, Coventry CV2 2DX, England.; Weickert, MO (corresponding author), Univ Warwick, Warwick Med Sch, Div Biomed Sci, Coventry CV2 2DX, England.; Weickert, MO (corresponding author), Univ Hosp Coventry & Warwickshire, NIHR CRF Human Metab Res Unit, Clifford Bridge Rd, Coventry CV2 2DX, England.; Weickert, MO (corresponding author), Coventry Univ, Fac Hlth & Life Sci, Ctr Sport Exercise & Life Sci, Coventry CV2 2DX, England.
EM martin.weickert@uhcw.nhs.uk
RI Weickert, Martin/C-2207-2009; Pfeiffer, Andreas/AAJ-2311-2020; Kabisch,
   Stefan/C-5106-2013
OI Barber, Thomas/0000-0003-0689-9195; Pfeiffer, Andreas F.
   H./0000-0002-6887-0016; Kabisch, Stefan/0000-0003-1792-1757; Weickert,
   Martin O/0000-0002-4070-8164
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NR 111
TC 61
Z9 62
U1 15
U2 34
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD APR 29
PY 2023
VL 15
IS 9
AR 2150
DI 10.3390/nu15092150
PG 17
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA G2PC6
UT WOS:000987629500001
PM 37432307
OA Green Published, gold
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Silva, KAS
   Freitas, DF
   Borem, LMA
   Oliveira, LP
   Oliveira, JR
   Paraíso, AF
   Guimaraes, ALS
   de Paula, AMB
   D'Angelis, CEM
   Santos, SHS
AF Souza Silva, Karinne Aparecida
   Freitas, Daniela Fernanda
   Araujo Borem, Luciana Mendes
   Oliveira, Luis Paulo
   Oliveira, Janaina Ribeiro
   Paraiso, Alanna Fernandes
   Sena Guimaraes, Andre Luiz
   Batista de Paula, Alfredo Mauricio
   Mendes D'Angelis, Carlos Eduardo
   Sousa Santos, Sergio Henrique
TI Resveratrol Attenuates Non-alcoholic Fatty Liver Disease in Obese Mice
   Modulating MAF1
SO REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY
LA English
DT Article
DE Metabolic syndrome; Hepatic steatosis; Obesity; Resveratrol; Sirtuins;
   Non-alcoholic fatty liver disease
ID RENIN-ANGIOTENSIN SYSTEM; ADIPOSE-TISSUE; DIET; RNA; LIPOGENESIS;
   INHIBITORS; EXPRESSION; SURVIVAL; MARKERS; SIRT1
AB In the present study, we aimed to evaluate the resveratrol effects on MAF1 liver pathway using a mice model of non-alcoholic fatty liver disease (NAFLD) induced by high-fat diet. Thirty-two male mice were divided into four groups and fed for 60 days with a standard diet, standard diet plus resveratrol (30 mg/kg/day by gavage for 4 weeks), high-fat diet, or high-fat diet plus resveratrol (30 mg/kg/day by gavage for 4 weeks). Metabolic parameters, insulin sensitivity, glucose tolerance, total cholesterol, triacylglycerides, glutamic-oxaloacetic transaminase, and glutamic-pyruvic transaminase levels were assessed. After sacrifice, adipose tissue and liver were weighed to evaluate lipid accumulation (via H&E and Sudan IV staining). The oxidative stress was analyzed by enzyme activity measurement of catalase and superoxide dismutase. mRNA expression of key genes (PTEN, MAF1, NNMT, and RXR alpha) were determined by quantitative real-time PCR (qRT-PCR). The resveratrol was able to significantly reduce the epididymal adipose tissue weight improving glycemic and lipid parameters. Hepatic liver accumulation was reduced also decreasing collagen deposition and improving catalase enzyme activity in the resveratrol-treated group. PTEN, MAF1, and NNMT expressions were improved and RXR alpha expression was decreased by resveratrol, suggesting the lipid profile enhancement in treated animals. In conclusion, the main results showed that a 4-week treatment with resveratrol improves hepatic conditions inducing a significant liver fat reduction in obese mice. The data indicates that the beneficial effects presented might be coordinated by the MAF1.
C1 [Souza Silva, Karinne Aparecida; Freitas, Daniela Fernanda; Araujo Borem, Luciana Mendes; Oliveira, Luis Paulo; Oliveira, Janaina Ribeiro; Sena Guimaraes, Andre Luiz; Batista de Paula, Alfredo Mauricio; Mendes D'Angelis, Carlos Eduardo; Sousa Santos, Sergio Henrique] Univ Estadual Montes Claros, Lab Pesquisa Saude, Programa Posgrad Ciencias Saude, Montes Claros, MG, Brazil.
   [Paraiso, Alanna Fernandes] Univ Fed Juiz de Fora, Programa Posgrad Enfermagem, Juiz De Fora, MG, Brazil.
   [Sousa Santos, Sergio Henrique] Univ Fed Minas Gerais, Fac Engn Alimentos, Inst Ciencias Agr, Ave Univ 1000, BR-39404547 Montes Claros, MG, Brazil.
C3 Universidade Estadual de Montes Claros; Universidade Federal de Juiz de
   Fora; Universidade Federal de Minas Gerais
RP Santos, SHS (corresponding author), Univ Estadual Montes Claros, Lab Pesquisa Saude, Programa Posgrad Ciencias Saude, Montes Claros, MG, Brazil.; Santos, SHS (corresponding author), Univ Fed Minas Gerais, Fac Engn Alimentos, Inst Ciencias Agr, Ave Univ 1000, BR-39404547 Montes Claros, MG, Brazil.
EM sergiosousas@ufing.br
RI Santos, Sérgio/D-8143-2011; De Paula, Alfredo/K-3015-2012; Freitas,
   Daniela/JMQ-2048-2023; Guimaraes, Andre/D-8122-2011
OI Freitas, Daniela/0000-0002-1050-5964; Santos,
   Sergio/0000-0002-7788-5447; Guimaraes, Andre/0000-0002-3162-3206;
   DANGELIS, CARLOS/0000-0003-4792-6962; Souza Silva,
   Karinne/0000-0002-7781-5318; De Paula, Alfredo/0000-0002-8715-0030
FU Fundacao de Amparo a Pesquisa do Estado de Minas Gerais (FAPEMIG,
   Brazil); Conselho Nacional de Desenvolvimento Cientifico e Tecnologico
   (CNPq, Brazil); Coordenacao de Aperfeicoamento de Pessoal de Nivel
   Superior (CAPES, Brazil)
FX The present study was supported in part by grants from Fundacao de
   Amparo a Pesquisa do Estado de Minas Gerais (FAPEMIG, Brazil), Conselho
   Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq, Brazil), and
   Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES,
   Brazil).
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NR 50
TC 3
Z9 3
U1 0
U2 13
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0102-695X
EI 1981-528X
J9 REV BRAS FARMACOGN
JI Rev. Bras. Farmacogn.-Braz. J. Pharmacogn.
PD OCT
PY 2022
VL 32
IS 5
BP 786
EP 795
DI 10.1007/s43450-022-00309-y
EA SEP 2022
PG 10
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 5C2ZQ
UT WOS:000859340300001
DA 2025-06-11
ER

PT J
AU Nazlic, J
   Juric, D
   Mudnic, I
   Boban, Z
   Dzelalija, AM
   Tandara, L
   Supe-Domic, D
   Gugo, K
   Boban, M
AF Nazlic, Jurica
   Juric, Diana
   Mudnic, Ivana
   Boban, Zvonimir
   Dzelalija, Ana Marija
   Tandara, Leida
   Supe-Domic, Daniela
   Gugo, Katarina
   Boban, Mladen
TI Effects of Moderate Consumption of Red Wine on Hepcidin Levels in
   Patients with Type 2 Diabetes Mellitus
SO FOODS
LA English
DT Article
DE type 2 diabetes; red wine; alternative-complementary therapy; iron;
   hepcidin; serum ferritin
ID SERUM HEPCIDIN; IRON-DEFICIENCY; ALCOHOL-CONSUMPTION;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; OXIDATIVE STRESS; FERRITIN;
   ANEMIA; INFLAMMATION; TRANSFERRIN
AB Iron overload is often associated with type 2 diabetes (T2D), indicating that hepcidin, the master regulator of iron homeostasis, might be involved in diabetes pathogenesis. Alcohol consumption may also result in increased body iron stores. However, the moderate consumption of wine with meals might be beneficial in T2D. This effect has been mainly attributed to both the ethanol and the polyphenolic compounds in wine. Therefore, we examined the effects of red wine on hepcidin in T2D patients and non-diabetic controls. The diabetic patients (n = 18) and age- and BMI-matched apparently healthy controls (n = 13) were men, aged 40-65 years, non-smoking, with BMI < 35 kg/m(2). Following a 2-week alcohol-free period, both groups consumed 300 mL of red wine for 3 weeks. The blood samples for the iron status analysis were taken at the end of each period. The red wine intake resulted in a decrease in serum hepcidin in both the diabetic subjects (p = 0.045) and controls (p = 0.001). The levels of serum ferritin also decreased after wine in both groups, reaching statistical significance only in the control subjects (p = 0.017). No significant alterations in serum iron, transferrin saturation, or soluble transferrin receptors were found. The suppression of hepcidin, a crucial iron-regulatory hormone and acute-phase protein, in T2D patients and healthy controls, is a novel biological effect of red wine. This may deepen our understanding of the mechanisms of the cardiometabolic effects of wine in T2D.
C1 [Nazlic, Jurica] Univ Hosp Split, Dept Intens Med & Clin Pharmacol, Soltanska 1, Split 21000, Croatia.
   [Juric, Diana; Mudnic, Ivana; Dzelalija, Ana Marija; Boban, Mladen] Univ Split, Dept Pharmacol, Sch Med, Soltanska 2, Split 21000, Croatia.
   [Boban, Zvonimir] Univ Split, Dept Med Phys & Biophys, Sch Med, Soltanska 2, Split 21000, Croatia.
   [Tandara, Leida; Supe-Domic, Daniela; Gugo, Katarina] Univ Hosp Split, Dept Med Lab Diagnost, Soltanska 1, Split 21000, Croatia.
   [Tandara, Leida] Univ Split, Dept Med Chem & Biochem, Sch Med, Soltanska 2, Split 21000, Croatia.
   [Supe-Domic, Daniela] Univ Split, Univ Dept Hlth Studies, Rudera Boskovica 35, Split 21000, Croatia.
C3 University of Split; University of Split; University of Split;
   University of Split; University of Split; University of Split
RP Juric, D (corresponding author), Univ Split, Dept Pharmacol, Sch Med, Soltanska 2, Split 21000, Croatia.
EM jnazlic@gmail.com; diana.juric@mefst.hr; ivana.mudnic@mefst.hr;
   zvonimir.boban@mefst.hr; ana.marija.dzelalija@mefst.hr;
   leida.tandara@gmail.com; daniela.supe.domic@ozs.unist.hr;
   katarina.gugo@gmail.com; mladen.boban@mefst.hr
RI Šupe-Domić, Daniela/Y-3169-2019; Tandara, Leida/E-1223-2017; Dzelalija,
   Ana Marija/E-6609-2017; Gujinovic, Diana/E-8810-2017; Boban,
   Mladen/E-2777-2017; Mudnic (Music), Ivana/E-4793-2017
OI Tandara, Leida/0000-0003-4175-6632; Dzelalija, Ana
   Marija/0000-0001-7184-1227; Boban, Zvonimir/0000-0003-1766-0120;
   Gujinovic, Diana/0000-0002-1846-2540; Boban, Mladen/0000-0003-1570-9621;
   Supe Domic, Daniela/0000-0002-5584-3182; Mudnic (Music),
   Ivana/0000-0003-4169-2886; Gugo, Katarina/0000-0002-3348-7586
FU Croatian Science Foundation [IP2013-11-8652]
FX This study was funded by the Croatian Science Foundation ("Biological
   effects of wine: the influence of vinification technology,
   dealcoholisation and aging of wine") under project no. IP2013-11-8652,
   with M.B. as the project leader.
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NR 60
TC 10
Z9 10
U1 1
U2 9
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2304-8158
J9 FOODS
JI Foods
PD JUL
PY 2022
VL 11
IS 13
AR 1881
DI 10.3390/foods11131881
PG 11
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA 2Y0SJ
UT WOS:000825604100001
PM 35804697
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Coronado, G
   Chio-Lauri, J
   Dela Cruz, R
   Roman, YM
AF Coronado, Gerald
   Chio-Lauri, Jacqueline
   Dela Cruz, Rosheanne
   Roman, Youssef M.
TI Health Disparities of Cardiometabolic Disorders Among Filipino
   Americans: Implications for Health Equity and Community-Based Genetic
   Research
SO JOURNAL OF RACIAL AND ETHNIC HEALTH DISPARITIES
LA English
DT Article
DE Filipinos; Minorities; Health disparities; Gout; Genetics; Diet;
   Community health; Cardiovascular diseases; Immigration; Acculturation;
   Precision medicine
ID RACIAL/ETHNIC DIFFERENCES; SOCIAL DETERMINANTS; ASIAN-AMERICANS;
   URIC-ACID; HYPERURICEMIA; GOUT; PREVALENCE; STRESS; RISK; DISCRIMINATION
AB Health disparities are well-documented among different racial and ethnic minority groups in the United States. Filipino Americans (FAs) are the third-largest Asian-American group in the USA and are commonly grouped under the Asian categorization. FAs have a higher prevalence of cardiometabolic disorders than non-Hispanic Whites and other Asian subgroups with rates comparable to African Americans. Although no major epidemiological studies have ascertained the prevalence of cardiometabolic diseases in FAs, limited reports suggest that FAs have a higher prevalence of dyslipidemia, hypertension, diabetes, metabolic syndrome, hyperuricemia, and gout than non-FAs. A recent genetic study has shown that FAs could have the highest prevalence of a genetic polymorphism strongly associated with the development of gout and gout-related comorbidities. While developing cardiometabolic disorders is a heterogeneous and multifaceted process, the overall prevalence of certain cardiometabolic disorders parallel the prevalence of population-level risk factors, including genetics, dietary lifestyles, health beliefs, and social determinants of health. Therefore, assessment of the Filipino cuisine, health behaviors among Filipinos, socio-cultural factors, and acculturation to living in the USA are equally critical. Ascertaining the contribution of the biological causes to disease onset and the different psychosocial factors that could modulate disease risk or disease management are needed. Ultimately, a multilevel research approach is critical to assess the role of biological and non-biological risk factors of cardiometabolic disorders in FAs to inform culturally appropriate health promotion, disease prevention strategies, and a personalized approach to health.
C1 [Coronado, Gerald] Virginia Commonwealth Univ, Sch Med, Richmond, VA 23298 USA.
   [Dela Cruz, Rosheanne; Roman, Youssef M.] Virginia Commonwealth Univ, Sch Pharm, Richmond, VA 23298 USA.
C3 Virginia Commonwealth University; Virginia Commonwealth University
RP Roman, YM (corresponding author), Virginia Commonwealth Univ, Sch Pharm, Richmond, VA 23298 USA.
EM coronadogm@vcu.edu; jlauri@myfoodbeginnings.com; delacruzrav@vcu.edu;
   romany2@vcu.edu
RI Roman, Youssef/U-2159-2019
OI Roman, Youssef/0000-0002-0613-5534
FU National Center for Advancing Translational Sciences [UL1TR002649]
   Funding Source: NIH RePORTER
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NR 69
TC 18
Z9 19
U1 0
U2 5
PU SPRINGER INT PUBL AG
PI CHAM
PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND
SN 2197-3792
EI 2196-8837
J9 J RACIAL ETHN HEALTH
JI J. Racial Ethn. Health Disparities
PD DEC
PY 2022
VL 9
IS 6
BP 2560
EP 2567
DI 10.1007/s40615-021-01190-6
EA NOV 2021
PG 8
WC Public, Environmental & Occupational Health
WE Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA 5X6KE
UT WOS:000722798900001
PM 34837163
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Werge, MP
   McCann, A
   Galsgaard, ED
   Holst, D
   Bugge, A
   Albrechtsen, NJW
   Gluud, LL
AF Werge, Mikkel Parsberg
   McCann, Adrian
   Galsgaard, Elisabeth Douglas
   Holst, Dorte
   Bugge, Anne
   Albrechtsen, Nicolai J. Wewer
   Gluud, Lise Lotte
TI The Role of the Transsulfuration Pathway in Non-Alcoholic Fatty Liver
   Disease
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Review
DE cystathionine beta-synthase/cystathionine gamma-lyase (CBS/CSE) system;
   glutathione; H2S production; liver fibrosis; non-alcoholic
   steatohepatitis; sulfur metabolism
ID CYSTATHIONINE BETA-SYNTHASE; SERUM HOMOCYSTEINE LEVELS; HYDROGEN-SULFIDE
   PRODUCTION; FARNESOID X RECEPTOR; NF-KAPPA-B; GAMMA-LYASE; OXIDATIVE
   STRESS; METHIONINE METABOLISM; AMINO-ACID; VITAMIN-B-6 DEFICIENCY
AB The prevalence of non-alcoholic fatty liver disease (NAFLD) is increasing and approximately 25% of the global population may have NAFLD. NAFLD is associated with obesity and metabolic syndrome, but its pathophysiology is complex and only partly understood. The transsulfuration pathway (TSP) is a metabolic pathway regulating homocysteine and cysteine metabolism and is vital in controlling sulfur balance in the organism. Precise control of this pathway is critical for maintenance of optimal cellular function. The TSP is closely linked to other pathways such as the folate and methionine cycles, hydrogen sulfide (H2S) and glutathione (GSH) production. Impaired activity of the TSP will cause an increase in homocysteine and a decrease in cysteine levels. Homocysteine will also be increased due to impairment of the folate and methionine cycles. The key enzymes of the TSP, cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE), are highly expressed in the liver and deficient CBS and CSE expression causes hepatic steatosis, inflammation, and fibrosis in animal models. A causative link between the TSP and NAFLD has not been established. However, dysfunctions in the TSP and related pathways, in terms of enzyme expression and the plasma levels of the metabolites (e.g., homocysteine, cystathionine, and cysteine), have been reported in NAFLD and liver cirrhosis in both animal models and humans. Further investigation of the TSP in relation to NAFLD may reveal mechanisms involved in the development and progression of NAFLD.
C1 [Werge, Mikkel Parsberg; Gluud, Lise Lotte] Copenhagen Univ Hosp Hvidovre, Gastro Unit, DK-2650 Hvidovre, Denmark.
   [McCann, Adrian] Bevital AS, N-5021 Bergen, Norway.
   [Galsgaard, Elisabeth Douglas; Holst, Dorte; Bugge, Anne] Novo Nordisk AS, Global Drug Discovery, Novo Nordisk Pk, DK-2760 Malov, Denmark.
   [Albrechtsen, Nicolai J. Wewer] Univ Copenhagen, NNF Ctr Prot Res, Fac Hlth & Med Sci, Clin Prote Grp, DK-2200 Copenhagen, Denmark.
   [Albrechtsen, Nicolai J. Wewer] Univ Copenhagen, Rigshosp, Dept Clin Biochem, DK-2100 Copenhagen, Denmark.
   [Albrechtsen, Nicolai J. Wewer] Univ Copenhagen, Fac Hlth & Med Sci, Dept Biomed Sci, DK-2200 Copenhagen, Denmark.
C3 University of Copenhagen; Novo Nordisk; University of Copenhagen;
   Rigshospitalet; University of Copenhagen; Copenhagen University
   Hospital; University of Copenhagen
RP Werge, MP (corresponding author), Copenhagen Univ Hosp Hvidovre, Gastro Unit, DK-2650 Hvidovre, Denmark.
EM mikkel.parsberg.werge@regionh.dk; adrian.mccann@bevital.no;
   edg@novonordisk.com; doho@novonordisk.com; azbu@novonordisk.com;
   nicolai.albrechtsen@sund.ku.dk; lise.lotte.gluud.01@regionh.dk
RI Gluud, Lise/AAY-2120-2020; Werge, Mikkel/P-2055-2019
OI Bugge, Anne/0000-0001-5885-4541; Werge, Mikkel/0000-0002-9980-1072;
   Wewer Albrechtsen, Nicolai/0000-0003-4230-5753; Gluud, Lise
   L/0000-0002-9462-4468; McCann, Adrian/0000-0002-5728-5321
FU Novo Nordisk; Novo Nordisk Foundation [NNF19OC0055001]
FX This research received support by Novo Nordisk, N.J.W.A, was supported
   by a grant from the Novo Nordisk Foundation (NNF19OC0055001).
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NR 152
TC 42
Z9 43
U1 3
U2 22
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD MAR
PY 2021
VL 10
IS 5
AR 1081
DI 10.3390/jcm10051081
PG 20
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA QV9EO
UT WOS:000628265700001
PM 33807699
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Beaupere, C
   Liboz, A
   Fève, B
   Blondeau, B
   Guillemain, G
AF Beaupere, Carine
   Liboz, Alexandrine
   Feve, Bruno
   Blondeau, Bertrand
   Guillemain, Ghislaine
TI Molecular Mechanisms of Glucocorticoid-Induced Insulin Resistance
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE insulin resistance; glucocorticoids; signaling pathway; liver; muscle;
   adipose tissue; pancreatic beta cells
ID 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1; PANCREATIC BETA-CELLS;
   ACTIVATED PROTEIN-KINASE; RAT SKELETAL-MUSCLE; ADIPOSE-TISSUE;
   MINERALOCORTICOID RECEPTOR; METABOLIC SYNDROME; GENE-EXPRESSION; MEMORY
   PERFORMANCE; DECLARATIVE MEMORY
AB Glucocorticoids (GCs) are steroids secreted by the adrenal cortex under the hypothalamic-pituitary-adrenal axis control, one of the major neuro-endocrine systems of the organism. These hormones are involved in tissue repair, immune stability, and metabolic processes, such as the regulation of carbohydrate, lipid, and protein metabolism. Globally, GCs are presented as 'flight and fight' hormones and, in that purpose, they are catabolic hormones required to mobilize storage to provide energy for the organism. If acute GC secretion allows fast metabolic adaptations to respond to danger, stress, or metabolic imbalance, long-term GC exposure arising from treatment or Cushing's syndrome, progressively leads to insulin resistance and, in fine, cardiometabolic disorders. In this review, we briefly summarize the pharmacological actions of GC and metabolic dysregulations observed in patients exposed to an excess of GCs. Next, we describe in detail the molecular mechanisms underlying GC-induced insulin resistance in adipose tissue, liver, muscle, and to a lesser extent in gut, bone, and brain, mainly identified by numerous studies performed in animal models. Finally, we present the paradoxical effects of GCs on beta cell mass and insulin secretion by the pancreas with a specific focus on the direct and indirect (through insulin-sensitive organs) effects of GCs. Overall, a better knowledge of the specific action of GCs on several organs and their molecular targets may help foster the understanding of GCs' side effects and design new drugs that possess therapeutic benefits without metabolic adverse effects.
C1 [Beaupere, Carine; Liboz, Alexandrine; Feve, Bruno; Blondeau, Bertrand; Guillemain, Ghislaine] Sorbonne Univ, Hosp Univ Inst, St Antoine Res Ctr, ICAN,INSERM,UMR S938, F-75012 Paris, France.
   [Feve, Bruno] Hop St Antoine, AP HP, Serv Endocrinol, F-75012 Paris, France.
C3 Institut National de la Sante et de la Recherche Medicale (Inserm);
   Assistance Publique Hopitaux Paris (APHP); Sorbonne Universite; Hopital
   Universitaire Saint-Antoine - APHP; Assistance Publique Hopitaux Paris
   (APHP); Sorbonne Universite; Hopital Universitaire Saint-Antoine - APHP
RP Blondeau, B; Guillemain, G (corresponding author), Sorbonne Univ, Hosp Univ Inst, St Antoine Res Ctr, ICAN,INSERM,UMR S938, F-75012 Paris, France.
EM carine.beaupere@inserm.fr; alexandrine.liboz@gmail.com;
   bruno.feve@inserm.fr; bertrand.blondeau@sorbonne-universite.fr;
   ghislaine.guillemain@inserm.fr
RI Guillemain, Ghislaine/P-7740-2017
OI Beaupere, Carine/0000-0002-7220-4892; Guillemain,
   Ghislaine/0000-0002-8256-9545; Blondeau, Bertrand/0000-0002-1106-1509
FU Institut National de la Sante et de la Recherche Medicale (INSERM),
   Sorbonne University; Fondation pour la Recherche Medicale (FRM)
   [EQU201903007868]; Association des Jeunes Diabetiques (AJD); Societe
   Francophone de Diabetologie (SFD); Ministere de l'Enseignement
   Superireur, de la Recherche et de l'Innovation
FX This work was funded by the Institut National de la Sante et de la
   Recherche Medicale (INSERM), Sorbonne University, the Fondation pour la
   Recherche Medicale (FRM grant number EQU201903007868), Association des
   Jeunes Diabetiques (AJD), and of the Societe Francophone de Diabetologie
   (SFD). A.L. is the recipient of a grant of the Ministere de
   l'Enseignement Superireur, de la Recherche et de l'Innovation.
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NR 203
TC 130
Z9 141
U1 2
U2 27
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD JAN
PY 2021
VL 22
IS 2
AR 623
DI 10.3390/ijms22020623
PG 30
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA PX4KS
UT WOS:000611326100001
PM 33435513
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Dewidar, B
   Kahl, S
   Pafili, K
   Roden, M
AF Dewidar, Bedair
   Kahl, Sabine
   Pafili, Kalliopi
   Roden, Michael
TI Metabolic liver disease in diabetes - From mechanisms to clinical trials
SO METABOLISM-CLINICAL AND EXPERIMENTAL
LA English
DT Review
DE Fatty liver; Type 2 diabetes; Insulin resistance; Biomarkers;
   Glucose-lowering drugs; Clinical trials
ID NONALCOHOLIC FATTY LIVER; GLP-1 RECEPTOR AGONIST; NECROSIS-FACTOR-ALPHA;
   INSULIN-RESISTANCE; HEPATIC STEATOSIS; MITOCHONDRIAL-FUNCTION; AMERICAN
   ASSOCIATION; PRACTICE GUIDELINES; BARIATRIC SURGERY; WEIGHT-LOSS
AB Non-alcoholic fatty liver disease (NAFLD) comprises fatty liver (steatosis), non-alcoholic steatohepatitis (NASH) and fibrosis/cirrhosis and may lead to end-stage liver failure or hepatocellular carcinoma. NAFLD is tightly associated with the most frequent metabolic disorders, such as obesity, metabolic syndrome, and type 2 diabetes mellitus (T2DM). Both multisystem diseases share several common mechanisms. Alterations of tissue communications include excessive lipid and later cytokine release by dysfunctional adipose tissue, intestinal dysbiosis and ectopic fat deposition in skeletal muscle. On the hepatocellular level, this leads to insulin resistance due to abnormal lipid handling and mitochondrial function. Over time, cellular oxidative stress and activation of inflammatory pathways, again supported by multiorgan crosstalk, determine NAFLD progression. Recent studies show that particularly the severe insulin resistant diabetes (SIRD) subgroup (cluster) associates with NAFLD and its accelerated progression and increases the risk of diabetes-related cardiovascular and kidney diseases, underpinning the critical role of insulin resistance. Consequently, lifestyle modification and certain drug classes used to treat T2DM have demonstrated effectiveness for treating NAFLD, but also some novel therapeutic concepts may be beneficial for both NAFLD and T2DM. This review addresses the bidirectional relationship between mechanisms underlying T2DM and NAFLD, the relevance of novel biomarkers for improving the diagnostic modalities and the identification of subgroups at specific risk of disease progression. Also, the role of metabolism-related drugs in NAFLD is discussed in light of the recent clinical trials. Finally, this review highlights some challenges to be addressed by future studies on NAFLD in the context of T2DM. (c) 2020 Elsevier Inc. All rights reserved.
C1 [Dewidar, Bedair; Kahl, Sabine; Pafili, Kalliopi; Roden, Michael] German Diabet Ctr, Inst Clin Diabetol, Dusseldorf, Germany.
   [Dewidar, Bedair; Kahl, Sabine] German Ctr Diabet Res, Munich, Germany.
   [Dewidar, Bedair] Tanta Univ, Dept Pharmacol & Toxicol, Fac Pharm, Tanta, Egypt.
   [Roden, Michael] Heinrich Heine Univ, Med Fac, Div Endocrinol & Diabetol, Dusseldorf, Germany.
C3 Leibniz Association; Deutsches Diabetes-Zentrum (DDZ); German Center for
   Diabetes Research (DZD); Egyptian Knowledge Bank (EKB); Tanta
   University; Heinrich Heine University Dusseldorf
RP Roden, M (corresponding author), Heinrich Heine Univ, German Diabet Ctr, Div Endocrinol & Diabetol, Med Fac, Hennekamp 65, D-40225 Dusseldorf, Germany.
EM michael.roden@ddz.de
RI Dewidar, Bedair/JGM-0415-2023; Pafili, Kalliopi/Y-5460-2019; Roden,
   Michael/AAD-3843-2019
OI Dewidar, Bedair/0000-0002-6678-0818; Pafili,
   Kalliopi/0000-0003-4293-3514
FU German Federal Ministry of Health (BMG); Ministry of Culture and Science
   of the State North Rhine-Westphalia (MKW NRW); German Federal Ministry
   of Education and Research (BMBF); European Funds for Regional
   Development [EFRE-0400191]; German Science Foundation (DFG) [CRC/SFB
   1116/2 B12]; Schmutzler Stiftung; German Diabetes Association (DDG);
   DZD; Gilead Sciences, Inc.; EUREKA Eurostars-2 [E! 113230 DIA-PEP]
FX The research of the authors is supported in part by grants from the
   German Federal Ministry of Health (BMG) and the Ministry of Culture and
   Science of the State North Rhine-Westphalia (MKW NRW) to the German
   Diabetes Center (DDZ), the German Federal Ministry of Education and
   Research (BMBF) to German Center for Diabetes Research (DZD e.V.). MR is
   further supported by grants from the European Funds for Regional
   Development (EFRE-0400191), EUREKA Eurostars-2 (E! 113230 DIA-PEP) and
   the German Science Foundation (DFG; CRC/SFB 1116/2 B12) and the
   Schmutzler Stiftung. SK is further supported by grants from the German
   Diabetes Association (DDG) and DZD. This article is published as part of
   a supplement sponsored by Gilead Sciences, Inc.
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NR 177
TC 123
Z9 129
U1 3
U2 27
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0026-0495
EI 1532-8600
J9 METABOLISM
JI Metab.-Clin. Exp.
PD OCT
PY 2020
VL 111
SU S
AR 154299
DI 10.1016/j.metabol.2020.154299
PG 14
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA NZ1FB
UT WOS:000576836200005
PM 32569680
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Bozaci, I
   Özkan, O
   Özkan, AA
   Koldas, M
   Öztürk, S
AF Bozaci, Ilter
   Ozkan, Oktay
   Ozkan, Alev Arat
   Koldas, Macit
   Ozturk, Savas
TI The Relationship Between Serum Vaspin Levels and the Degree of Coronary
   Involvement in Patients with Stable Angina Pectoris
SO HASEKI TIP BULTENI-MEDICAL BULLETIN OF HASEKI
LA English
DT Article
DE Vaspin; angina pectoris; Gensini score
ID METABOLIC SYNDROME; INFLAMMATION; ATHEROSCLEROSIS; ADIPONECTIN; OBESITY
AB Aim: Vaspin is an insulin-sensitive adipokine secreted from visceral fat tissue, and belongs to the serine protease inhibitor family. The relationship between vaspin level and coronary artery disease is not known yet. We aimed to investigate the relationship between serum vaspin levels and degree of vessel involvement in coronary angiography in patients with stable angina pectoris.
   Methods: The patients were chosen from those who had coronary angiography with the diagnosis of stable angina pectoris. Patients with previously diagnosed chronic heart disease, chronic liver disease, renal failure, thyroid dysfunction and any systemic infectious or malignant disease, patients receiving immunosupressive treatment and those who did not give informed consent were excluded from the study. Serum vaspin measurements were performed using an East Biopharm enzyme-linked immunoassay (ELISA) kit using the sandwich ELISA method. For determination of the severity of coronary lesions, the modified Gensini score was used.
   Results: Eighty-eight patients [34 female (38.6%) and 54 male (91.4%)] were included in the study. Vaspin levels were similar in male (1.17 +/- 1.54 ng/L) and female (1.09 +/- 1.23 ng/L) patients (p=0.46). There was no correlation between vaspin levels and the number of vessels involved (p=0.75). Vaspin levels were similar in diabetic and nondiabetic patients.
   Conclusion: Vaspin may not be a sensitive marker of the degree of vascular lesions in patients with stable angina pectoris. The underlying cause is probably lack of significant changes in inflammatory cascade and oxidative stress in the involved group of patients.
C1 [Bozaci, Ilter] Bozyaka Training & Res Hosp, Clin Nephrol, Izmir, Turkey.
   [Ozkan, Oktay; Ozturk, Savas] Univ Hlth Sci Turkey, Haseki Taining & Res Hosp, Clin Nephrol, Istanbul, Turkey.
   [Ozkan, Alev Arat] Istanbul Univ, Dept Cardiol, Inst Cardiol, Istanbul, Turkey.
   [Koldas, Macit] Univ Hlth Sci Turkey, Haseki Training & Res Hosp, Clin Biochem, Istanbul, Turkey.
C3 Izmir Bozyaka Training & Research Hospital; Istanbul University;
   Istanbul Haseki Training & Research Hospital
RP Bozaci, I (corresponding author), Bozyaka Training & Res Hosp, Clin Nephrol, Izmir, Turkey.
EM ilterbozaci@gmail.com
RI Arat-Özkan, Alev/A-8073-2016; , Macit/A-7784-2018
OI , Macit/0000-0001-8967-2708; BOZACI, ILTER/0000-0001-7535-9403
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NR 33
TC 1
Z9 1
U1 0
U2 2
PU GALENOS YAYINCILIK
PI FINDIKZADE
PA MOLLA GURANI MAHALLESI KACAMAK SOKAK NO 21, FINDIKZADE, ISTANBUL 34093,
   TURKEY
SN 1302-0072
EI 2147-2688
J9 HASEKI TIP BUL
JI Haseki Tip Bul.
PD MAR
PY 2020
VL 58
IS 2
BP 176
EP 182
DI 10.4274/haseki.galenos.2020.5864
PG 7
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA KW3WT
UT WOS:000521098000010
OA gold
DA 2025-06-11
ER

PT J
AU Li, WZ
   Chen, ZL
   Ruan, WY
   Yi, GL
   Wang, DM
   Lu, ZX
AF Li, Wenzhen
   Chen, Zhenlong
   Ruan, Wenyu
   Yi, Guilin
   Wang, Dongming
   Lu, Zuxun
TI A meta-analysis of cohort studies including dose-response relationship
   between shift work and the risk of diabetes mellitus
SO EUROPEAN JOURNAL OF EPIDEMIOLOGY
LA English
DT Article
DE Shift work; Diabetes mellitus; Cohort; Meta-analysis; Dose-response
   relationship
ID CAUSE-SPECIFIC MORTALITY; METABOLIC SYNDROME; CHRONIC DISEASE; NIGHT;
   ASSOCIATION; STRESS; IMPACTS; BIAS
AB Previous reviews have suggested that shift work is associated with an increased risk of diabetes mellitus (DM); however, the results should be interpreted with caution due to differences in study designs and non-comprehensive literature searches. In addition, the quantitative dose-response relationship between years of shift work and DM risk is still unknown. We aimed to conduct an updated meta-analysis with cohort studies and to evaluate the relationship between the duration of shift work and the risk of DM in a dose-dependent manner. The PubMed and Web of Science databases were searched through 15 August 2019, and multivariate-adjusted relative risks (RRs) were pooled using random-effects models. Restricted cubic spline analysis with three knots was used to explore the relationship of years of shift work and risk of DM. Twelve cohort studies with 28 independent reports involving 244,266 participants and 15,906 DM cases were included. The summarized adjusted RR for the relationship between shift work and DM risk was 1.14 (95% CI 1.10 to 1.19; I-2 = 38.9%, P = 0.028). The summary RR of a 5-year increase in shift work was 1.07 (95% CI 1.04 to 1.09), without heterogeneity (I-2= 0.0%, P = 0.829) for the female population. Shift work is associated with an increased risk of DM, and a strong and highly significant linear dose-response relationship between the duration of shift work and the risk of DM in women was observed. Further studies are needed to confirm the results, establish causality and elucidate the underlying mechanisms.
C1 [Li, Wenzhen; Lu, Zuxun] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Dept Social Med & Hlth Management, 13 Hangkong Rd, Wuhan 430030, Hubei, Peoples R China.
   [Chen, Zhenlong; Yi, Guilin] Wuhan Prevent & Treatment Ctr Occupat Dis, Wuhan 430015, Hubei, Peoples R China.
   [Ruan, Wenyu] Shangluo Cent Hosp, Shangluo 726000, Shanxi, Peoples R China.
   [Wang, Dongming] Huazhong Univ Sci & Technol, Sch Publ Hlth, Tongji Med Coll, Dept Occupat & Environm Hlth, Wuhan 430030, Hubei, Peoples R China.
   [Wang, Dongming] Huazhong Univ Sci & Technol, Sch Publ Hlth, Tongji Med Coll, Key Lab Environm & Hlth,Minist Educ, Wuhan 430030, Hubei, Peoples R China.
   [Wang, Dongming] Huazhong Univ Sci & Technol, Sch Publ Hlth, Tongji Med Coll, Minist Environm Protect, Wuhan 430030, Hubei, Peoples R China.
   [Wang, Dongming] Huazhong Univ Sci & Technol, Sch Publ Hlth, Tongji Med Coll, State Key Lab Environm Hlth Incubating, Wuhan 430030, Hubei, Peoples R China.
C3 Huazhong University of Science & Technology; Huazhong University of
   Science & Technology; Huazhong University of Science & Technology;
   Ministry of Education - China; Huazhong University of Science &
   Technology; Huazhong University of Science & Technology
RP Lu, ZX (corresponding author), Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Dept Social Med & Hlth Management, 13 Hangkong Rd, Wuhan 430030, Hubei, Peoples R China.; Wang, DM (corresponding author), Huazhong Univ Sci & Technol, Sch Publ Hlth, Tongji Med Coll, Dept Occupat & Environm Hlth, Wuhan 430030, Hubei, Peoples R China.; Wang, DM (corresponding author), Huazhong Univ Sci & Technol, Sch Publ Hlth, Tongji Med Coll, Key Lab Environm & Hlth,Minist Educ, Wuhan 430030, Hubei, Peoples R China.; Wang, DM (corresponding author), Huazhong Univ Sci & Technol, Sch Publ Hlth, Tongji Med Coll, Minist Environm Protect, Wuhan 430030, Hubei, Peoples R China.; Wang, DM (corresponding author), Huazhong Univ Sci & Technol, Sch Publ Hlth, Tongji Med Coll, State Key Lab Environm Hlth Incubating, Wuhan 430030, Hubei, Peoples R China.
EM wangdongming2008@126.com; zuxunlu@yahoo.com
FU Young Scientists Fund of the National Natural Science Foundation of
   China [81903291]; Fundamental Research Funds for the Central
   Universities [2019kfyXJJS032]; China Postdoctoral Science Foundation
   [2019T120666]; Key project of Wuhan Municipal Health Committee [WG16B08]
FX The study was supported by the Young Scientists Fund of the National
   Natural Science Foundation of China (81903291), the Fundamental Research
   Funds for the Central Universities (2019kfyXJJS032), China Postdoctoral
   Science Foundation (2019T120666), and Key project of Wuhan Municipal
   Health Committee (WG16B08). The funding source had no role in the design
   and conduct of the study; collection, management, analysis, and
   interpretation of the data; preparation, review, or approval of the
   manuscript; and decision to submit the manuscript for publication.
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NR 44
TC 43
Z9 48
U1 0
U2 13
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0393-2990
EI 1573-7284
J9 EUR J EPIDEMIOL
JI Eur. J. Epidemiol.
PD NOV
PY 2019
VL 34
IS 11
BP 1013
EP 1024
DI 10.1007/s10654-019-00561-y
PG 12
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA KN5DY
UT WOS:000514858700004
PM 31512118
DA 2025-06-11
ER

PT J
AU Zheng, WL
   Mu, JJ
   Chu, C
   Hu, JW
   Yan, Y
   Ma, Q
   Lv, YB
   Xu, XJ
   Wang, KK
   Wang, Y
   Deng, Y
   Yan, B
   Yang, RH
   Yang, J
   Ren, Y
   Yuan, ZY
AF Zheng, Wenling
   Mu, Jianjun
   Chu, Chao
   Hu, Jiawen
   Yan, Yu
   Ma, Qiong
   Lv, Yongbo
   Xu, Xianjing
   Wang, Keke
   Wang, Yang
   Deng, Ying
   Yan, Bo
   Yang, Ruihai
   Yang, Jun
   Ren, Yong
   Yuan, Zuyi
TI Association of Blood Pressure Trajectories in Early Life with
   Subclinical Renal Damage in Middle Age
SO JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
LA English
DT Article
ID CHRONIC KIDNEY-DISEASE; METABOLIC SYNDROME; YOUNG ADULTHOOD; GEORGIA
   STRESS; RISK-FACTORS; CHILDHOOD; HYPERTENSION; PREVALENCE; VARIABILITY;
   GROWTH
AB Background Although high BP is one of the most important factors affecting renal function, whether longitudinal BP trajectories in early life course are associated with renal function damage in later life is unclear.
   Methods To investigate the correlation between BP trajectories from childhood to adulthood and renal function in middle age, we used group-based trajectory models to identify BP trajectories in 2430 individuals (aged 6-15 years old at baseline) participating in the ongoing Hanzhong Adolescent Hypertension Cohort. We tested the association between these trajectories and subclinical renal damage in middle age, adjusting for several covariates.
   Results We identified four distinct systolic BP trajectories among 2430 subjects: low stable, moderate stable, high stable, and moderate increasing on the basis of systolic BP levels at baseline and during the 30-year follow-up period. The urinary albumin-to-creatinine ratio (uACR) was higher in moderate stable, high stable, and moderate increasing groups compared with the low stable group. A total of 228 individuals had subclinical renal disease by 2017. Compared with the low stable trajectory group, the other groups had increasingly greater odds of experiencing subclinical renal disease in middle age. These associations were not altered after adjustment for other covariates, except for in the moderate stable group. Analyzed results were similar for the mean arterial pressure and diastolic BP trajectory groups.
   Conclusions Higher BP trajectories were correlated with higher of uACR levels and risk of subclinical renal disease in middle age. Identifying long-term BP trajectories from early age may assist in predicting individuals' renal function in later life.
C1 [Zheng, Wenling; Mu, Jianjun; Chu, Chao; Hu, Jiawen; Yan, Yu; Ma, Qiong; Wang, Keke; Wang, Yang; Yuan, Zuyi] Xi An Jiao Tong Univ, Affiliated Hosp 1, Med Coll, Dept Cardiovasc Med, 277 Yanta West Rd, Xian 710061, Shaanxi, Peoples R China.
   [Zheng, Wenling; Mu, Jianjun; Chu, Chao; Hu, Jiawen; Yan, Yu; Ma, Qiong; Wang, Keke; Wang, Yang; Yuan, Zuyi] Minist Educ, Key Lab Environm & Genes Related Dis, Xian, Shaanxi, Peoples R China.
   [Lv, Yongbo] Xi An Jiao Tong Univ, Affiliated Hosp 2, Med Coll, Dept Cardiovasc Med, Xian, Shaanxi, Peoples R China.
   [Xu, Xianjing] Henan Prov Peoples Hosp, Dept Cardiovasc Med, Zhengzhou, Henan, Peoples R China.
   [Deng, Ying] Dept Cardiovasc Med, Hanzhong 405 Hosp, Hanzhong, Peoples R China.
   [Yan, Bo] Hanzhong Cent Hosp, Dept Cardiovasc Med, Hanzhong, Peoples R China.
   [Yang, Ruihai; Yang, Jun; Ren, Yong] Hanzhong Peoples Hosp, Inst Cardiovasc Sci, Hanzhong, Peoples R China.
C3 Xi'an Jiaotong University; Ministry of Education - China; Xi'an Jiaotong
   University; Zhengzhou University
RP Mu, JJ (corresponding author), Xi An Jiao Tong Univ, Affiliated Hosp 1, Med Coll, Dept Cardiovasc Med, 277 Yanta West Rd, Xian 710061, Shaanxi, Peoples R China.
EM mujjun@163.com
RI Yan, Bo/AFQ-7025-2022; Yan, Yu/KAM-4269-2024
OI Yuan, Zuyi/0000-0002-4141-0298; Yan, Yu/0000-0001-5942-5853; Lyu,
   Yongbo/0000-0002-1759-8673
FU Clinical Research Award of the First Affiliated Hospital of Xi'an
   Jiaotong University of China [XJTU1AF-CRF-2015-006]; National Natural
   Science Foundation of China [81370357, 81570381, 81700368, 81600327];
   Major Chronic Non-Communicable Disease Prevention and Control Research
   Key Project of the Ministry of Science and Technology of the People's
   Republic of China [2017YFC1307604]; Key Research Project of Shaanxi
   Province [2017ZDXM-SF-107]
FX This work was supported by Clinical Research Award of the First
   Affiliated Hospital of Xi'an Jiaotong University of China grant
   XJTU1AF-CRF-2015-006; National Natural Science Foundation of China
   grants 81370357, 81570381 (to J.M.), 81700368 (to C.C.), and 81600327
   (to Y.W.); Major Chronic Non-Communicable Disease Prevention and Control
   Research Key Project of the Ministry of Science and Technology of the
   People's Republic of China grant 2017YFC1307604; and Key Research
   Project of Shaanxi Province grant 2017ZDXM-SF-107.
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NR 43
TC 64
Z9 74
U1 0
U2 21
PU AMER SOC NEPHROLOGY
PI WASHINGTON
PA 1725 I ST, NW STE 510, WASHINGTON, DC 20006 USA
SN 1046-6673
EI 1533-3450
J9 J AM SOC NEPHROL
JI J. Am. Soc. Nephrol.
PD DEC
PY 2018
VL 29
IS 12
BP 2835
EP 2846
DI 10.1681/ASN.2018030263
PG 12
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA HC3JL
UT WOS:000451698200009
PM 30420422
OA Green Published
DA 2025-06-11
ER

PT J
AU Namazi, N
   Larijani, B
   Ayati, MH
   Abdollahi, M
AF Namazi, Nazli
   Larijani, Bagher
   Ayati, Mohammad Hossein
   Abdollahi, Mohammad
TI The effects of Nigella sativa L. on obesity: A systematic review
   and meta analysis
SO JOURNAL OF ETHNOPHARMACOLOGY
LA English
DT Review
DE N.sativa; Weight; Abdominal obesity; Complementary therapy
ID DOUBLE-BLIND; INSULIN-RESISTANCE; METABOLIC SYNDROME; LIPID PROFILE;
   PPAR-GAMMA; OIL; EXTRACT; STRESS; SEEDS; SUPPLEMENTATION
AB Ethnopharmacological relevance: Nigella sativa L. (N.sativa) is a traditional herbal medicine that has been used for centuries to treat rheumatoid arthritis, diabetes, asthma, and other metabolic disorders. Recently, anti-obesity characteristics of N.sativa have been indicated.
   Aim of the study: The effects of N. sativa as a complementary therapy in obesity management remains controversial. We aimed to perform a meta-analysis on the effects of supplementation with N. saliva on some anthropometric indices in adult subjects.
   Materials and methods: We searched PubMed/Medline, Cochrane Library, ISI Web of Science, and Scopus databases until June 2017 to identify relevant placebo-controlled clinical trials. Data was reported as weighted mean differences and standard deviations to show the magnitude of effects for N. saliva on body weight, body mass index (BMI) and waist circumference (WC).
   Results: Findings of 11 studies revealed that N. saliva supplement reduced body weight (-2.11 kg, 95% CI: -3.61, -0.61, I-2:72.4%), BMI (-1.16 kg/m(2); 95%CI: -1.81, -0.51; I-2: 40.1%) and WC (-3.52 cm, 95%CI: -4.10, -2.92, I-2 = 0%) significantly compared to placebo groups.
   Conclusion: Supplementation with N. sativa exerts a moderate effect on reduction in body weight, BMI and WC. However, due to the high heterogeneity for body weight and limited high quality studies, the findings should be declared by caution. No serious side effects were also reported following N. saliva supplementation. Further studies are needed to clarify the effects of N. saliva on other anthropometric indices.
C1 [Namazi, Nazli] Univ Tehran Med Sci, Endocrinol & Metab Mol Cellular Sci Inst, Obes & Eating Habits Res Ctr, Tehran, Iran.
   [Larijani, Bagher] Univ Tehran Med Sci, Endocrinol & Metab Clin Sci Inst, Endocrinol & Metab Res Ctr, Tehran, Iran.
   [Ayati, Mohammad Hossein] Univ Tehran Med Sci, Sch Tradit Med, Tehran, Iran.
   [Abdollahi, Mohammad] Univ Tehran Med Sci, Pharmaceut Sci Res Ctr, Fac Pharm, Dept Pharmacol & Toxicol, Tehran, Iran.
C3 Tehran University of Medical Sciences; Tehran University of Medical
   Sciences; Tehran University of Medical Sciences; Tehran University of
   Medical Sciences
RP Larijani, B (corresponding author), Univ Tehran Med Sci, Endocrinol & Metab Clin Sci Inst, Endocrinol & Metab Res Ctr, Tehran, Iran.; Ayati, MH (corresponding author), Univ Tehran Med Sci, Sch Tradit Med, Tehran, Iran.; Abdollahi, M (corresponding author), Univ Tehran Med Sci, Pharmaceut Sci Res Ctr, Fac Pharm, Dept Pharmacol & Toxicol, Tehran, Iran.
EM nazli.namazi@yahoo.com; larijanib@tums.ac.ir; mh-ayati@tums.ac.ir;
   mohammad.abdollahi@utoronto.ca
RI larijani, Bagher/ABE-3315-2020; Ayati, Mohammad/I-1221-2019;
   /B-9232-2008
OI Ayati, Mohammad Hossein/0000-0002-1290-1135; Larijani,
   Bagher/0000-0001-5386-7597; /0000-0003-0123-1209
FU Iran National Science Foundation [95013061]; Endocrine & Metabolism
   Research Institute, Tehran University of Medical Sciences
   [1395-02-105-2070]
FX We would like to express our sincere thanks to Iran National Science
   Foundation (grant number: 95013061) and Endocrine & Metabolism Research
   Institute, Tehran University of Medical Sciences (grant number:
   1395-02-105-2070) for their financial support.
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NR 46
TC 54
Z9 58
U1 1
U2 16
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0378-8741
EI 1872-7573
J9 J ETHNOPHARMACOL
JI J. Ethnopharmacol.
PD JUN 12
PY 2018
VL 219
BP 173
EP 181
DI 10.1016/j.jep.2018.03.001
PG 9
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA GI9YL
UT WOS:000434901400016
PM 29559374
OA Bronze
DA 2025-06-11
ER

PT J
AU Sato, K
   Shirai, R
   Yamaguchi, M
   Yamashita, T
   Shibata, K
   Okano, T
   Mori, Y
   Matsuyama, TA
   Ishibashi-Ueda, H
   Hirano, T
   Watanabe, T
AF Sato, Kengo
   Shirai, Remina
   Yamaguchi, Maho
   Yamashita, Tomoyuki
   Shibata, Koichiro
   Okano, Taisuke
   Mori, Yusaku
   Matsuyama, Taka-aki
   Ishibashi-Ueda, Hatsue
   Hirano, Tsutomu
   Watanabe, Takuya
TI Anti-Atherogenic Effects of Vaspin on Human Aortic Smooth Muscle
   Cell/Macrophage Responses and Hyperlipidemic Mouse Plaque Phenotype
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE vaspin; atherosclerosis; macrophage; vascular smooth muscle cell;
   Apoe(-/-) mice
ID VASCULAR ENDOTHELIAL-CELLS; ACUTE CORONARY SYNDROME; ADIPOSE-TISSUE;
   PLASMA VASPIN; KAPPA-B; INSULIN-RESISTANCE; METABOLIC SYNDROME; INDUCED
   APOPTOSIS; HIGH GLUCOSE; ER STRESS
AB Vaspin (visceral adipose tissue-derived serine protease inhibitor) was recently identified as a novel adipocytokine with insulin-sensitizing effects. Serum vaspin levels are reported either increased or decreased in patients with coronary artery disease. Our translational research was performed to evaluate the expression of vaspin in human coronary atherosclerotic lesions, and its effects on atherogenic responses in human macrophages and human aortic smooth muscle cells (HASMC), as well as aortic atherosclerotic lesion development in spontaneously hyperlipidemic Apoe(-/-) mice, an animal model of atherosclerosis. Vaspin was expressed at high levels in macrophages/vascular smooth muscle cells (VSMCs) within human coronary atheromatous plaques. Vaspin significantly suppressed inflammatory phenotypes with nuclear factor B down-regulation in human macrophages. Vaspin significantly suppressed oxidized low-density lipoprotein-induced foam cell formation with CD36 and acyl-coenzyme A: cholesterol acyltransferase-1 down-regulation and ATP-binding cassette transporters A1 and G1, and scavenger receptor class B type 1 up-regulation in human macrophages. Vaspin significantly suppressed angiotensin II-induced migration and proliferation with ERK1/2 and JNK down-regulation, and increased collagen production with phosphoinositide 3-kinase and Akt up-regulation in HASMCs. Chronic infusion of vaspin into Apoe(-/-) mice significantly suppressed the development of aortic atherosclerotic lesions, with significant reductions of intraplaque inflammation and the macrophage/VSMC ratio, a marker of plaque instability. Our study indicates that vaspin prevents atherosclerotic plaque formation and instability, and may serve as a novel therapeutic target in atherosclerotic cardiovascular diseases.
C1 [Sato, Kengo; Shirai, Remina; Yamaguchi, Maho; Yamashita, Tomoyuki; Shibata, Koichiro; Okano, Taisuke; Watanabe, Takuya] Tokyo Univ Pharm & Life Sci, Lab Cardiovasc Med, Tokyo 1920392, Japan.
   [Mori, Yusaku; Hirano, Tsutomu] Showa Univ, Sch Med, Div Diabet Metab & Endocrinol, Dept Med, Tokyo 1428666, Japan.
   [Matsuyama, Taka-aki] Showa Univ, Sch Med, Dept Legal Med, Tokyo 1428555, Japan.
   [Matsuyama, Taka-aki; Ishibashi-Ueda, Hatsue] Natl Cerebral & Cardiovasc Ctr, Dept Pathol, Osaka 5658565, Japan.
C3 Tokyo University of Pharmacy & Life Sciences; Showa University; Showa
   University; National Cerebral & Cardiovascular Center - Japan
RP Watanabe, T (corresponding author), Tokyo Univ Pharm & Life Sci, Lab Cardiovasc Med, Tokyo 1920392, Japan.
EM ksato@toyaku.ac.jp; s106101@toyaku.ac.jp; s139110@toyaku.ac.jp;
   s126208@toyaku.ac.jp; s149064@toyaku.ac.jp; s149021@toyaku.ac.jp;
   torigoe1234@yahoo.co.jp; taka94242879@gmail.com; hueda@ncvc.go.jp;
   hirano@med.showa-u.ac.jp; watanabe@toyaku.ac.jp
OI Watanabe, Takuya/0000-0001-9996-2063; hirano,
   tsutomu/0000-0003-1859-0005
FU Japan Society for the Promotion of Science (JSPS) [25860418, 16K08943,
   17K08993];  [17J02716]; Grants-in-Aid for Scientific Research [17K08993,
   25860418] Funding Source: KAKEN
FX This work was supported in part by a Grant-in-Aid for Young Scientists
   (B) (25860418 to K.Sato), Grants-in-Aid for Scientific Research (C)
   (16K08943 to K.Sato and 17K08993 to T.W.) from the Japan Society for the
   Promotion of Science (JSPS), and a Grant-in-Aid for JSPS Fellows (DC2,
   17J02716 to R.S.).
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NR 50
TC 21
Z9 23
U1 0
U2 3
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD JUN
PY 2018
VL 19
IS 6
AR 1732
DI 10.3390/ijms19061732
PG 15
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA GK8UZ
UT WOS:000436506600187
PM 29891806
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Fuller, KNZ
   Summers, CM
   Valentine, RJ
AF Fuller, Kelly N. Z.
   Summers, Corey M.
   Valentine, Rudy J.
TI Effect of a single bout of aerobic exercise on high-fat meal-induced
   inflammation
SO METABOLISM-CLINICAL AND EXPERIMENTAL
LA English
DT Article
DE Peripheral blood mononuclear cells; AMP-activated protein kinase;
   Postprandial lipemia; Nuclear factor-kappa B
ID ACTIVATED PROTEIN-KINASE; BLOOD MONONUCLEAR-CELLS; INSULIN-RESISTANCE;
   POSTPRANDIAL LIPEMIA; ENDURANCE EXERCISE; RETICULUM STRESS; AMPK
   ACTIVATION; NORMAL-WEIGHT; METABOLISM; OBESE
AB Background and aims. Chronic low-grade inflammation is involved in the development of metabolic disorders including atherosclerosis, type 2 diabetes (T2D) and metabolic syndrome. Aerobic exercise has been shown to be anti-inflammatory and attenuate postprandial blood lipids, however, the effect of exercise on postprandial inflammation remains unclear. The aim of this study was to determine the protective effect of a single bout of aerobic exercise against postprandial lipemia and peripheral blood mononuclear cell (PBMC) inflammation and to evaluate associations with changes in the energy-sensing enzyme, AMP-activated protein kinase (AMPK).
   Materials and methods. Healthy male subjects (n = 12, age = 23 +/- 2, %Fat = 19 +/- 2) reported to the laboratory following an overnight fast (12-14 h) on two separate occasions for consumption of a high-fat meal (HFM). Participants completed an acute bout of aerobic exercise the afternoon prior to one of the HFM visits.
   Results and conclusion. Results indicate that the single bout of moderate aerobic exercise increased AMPK signaling in PBMCs, as shown by increased phosphorylated acetyl-CoA carboxylase (p-ACC). This may be due to decreases in the AMPK inhibitory kinases PKD and GSK3 beta. Additionally, prior moderate intensity exercise decreased postprandial lipemia (PPL) and some mediators of the inflammatory pathway, such as p-NF-kappa B. These findings that acute aerobic exercise improves AMPK and NF-kappa B signaling in human PBMCs contribute support to the anti-inflammatory roles of exercise. (C) 2017 Elsevier Inc. All rights reserved.
C1 [Fuller, Kelly N. Z.] Iowa State Univ, Interdept Grad Program Nutr Sci, Ames, IA USA.
   [Fuller, Kelly N. Z.; Summers, Corey M.; Valentine, Rudy J.] Iowa State Univ, Dept Kinesiol, Ames, IA USA.
   [Summers, Corey M.] Iowa State Univ, Immunobiol Interdept Grad Program, Ames, IA USA.
C3 Iowa State University; Iowa State University; Iowa State University
RP Valentine, RJ (corresponding author), Dept Kinesiol, Ames, IA 50011 USA.
EM rvalenti@iastate.edu
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NR 49
TC 17
Z9 21
U1 2
U2 18
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0026-0495
EI 1532-8600
J9 METABOLISM
JI Metab.-Clin. Exp.
PD JUN
PY 2017
VL 71
BP 144
EP 152
DI 10.1016/j.metabol.2017.03.001
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA EW5YW
UT WOS:000402583400015
PM 28521867
DA 2025-06-11
ER

PT J
AU Chen, J
   Wang, SD
   Luo, MY
   Zhang, ZG
   Dai, XZ
   Kong, MY
   Cai, L
   Wang, YH
   Shi, BY
   Tan, Y
AF Chen, Jun
   Wang, Shudong
   Luo, Manyu
   Zhang, Zhiguo
   Dai, Xiaozhen
   Kong, Maiying
   Cai, Lu
   Wang, Yuehui
   Shi, Bingyin
   Tan, Yi
TI From the Cover: Zinc Deficiency Worsens and Supplementation Prevents
   High-Fat Diet Induced Vascular Inflammation, Oxidative Stress, and
   Pathological Remodeling
SO TOXICOLOGICAL SCIENCES
LA English
DT Article
DE zinc; high fat diet; antioxidant; vascular disease; inflammation
ID UP-REGULATION; METABOLIC SYNDROME; NRF2 EXPRESSION; CARDIOVASCULAR RISK;
   PHYSICAL-ACTIVITY; DIABETIC MICE; MOUSE MODEL; CELL-DEATH; IN-VIVO;
   OBESITY
AB Obesity has become a common public health problem in the world and raises the risk of various cardiovascular diseases. Zinc is essential for multiple organs in terms of normal structure and function. The present study investigated the effects of high fat diet (HFD) induced obesity on the aorta in mice, and evaluated whether it can be affected by zinc deficiency or supplementation. Four-week-old male C57BL/6J mice were fed HFD with varied amounts of zinc (deficiency, adequate and supplementation) for 3 and 6 months. Results showed that HFD feeding induced a time-dependent aortic remodeling, demonstrated by increased vessel wall thickness, tunica cell proliferation and fibrotic responses, and inflammatory response, reflected by increased expression of inflammatory cytokines (tumor necrosis factor-alpha and vascular cell adhesion molecule 1). HFD feeding also caused aortic oxidative damage, reflected by 3-nitrotyrosine and 4-hydroxy-2-nonenal accumulation, and down-regulated nuclear factor (erythroid-derived 2)-like 2 (Nrf2) expression and function, shown by down-regulation of its downstream antioxidants, catalase, NAD(P)H dehydrogenase (quinone 1), and metallothionein expression. The vascular effects of obesity-induced by HFD was exacerbated by zinc deficiency but significantly improved by zinc supplementation. In addition, down-regulation of Nrf2 function and associated antioxidants expression were also worsened by zinc deficiency but improved by zinc supplementation. These results suggest that HFD induces aortic remodeling, which can be exacerbated by zinc deficiency and improved by zinc supplementation.
C1 [Chen, Jun; Shi, Bingyin] Xi An Jiao Tong Univ, Sch Med, Affiliated Hosp 1, Dept Endocrinol, Xian 710061, Peoples R China.
   [Chen, Jun; Cai, Lu; Tan, Yi] Wenzhou Med Univ, Sch Pharmaceut Sci, Chinese Amer Res Inst Diabet Complicat, Wenzhou 325035, Peoples R China.
   [Chen, Jun; Cai, Lu; Tan, Yi] Wenzhou Med Univ, Sch Nursing, Wenzhou 325035, Peoples R China.
   [Chen, Jun; Wang, Shudong; Luo, Manyu; Dai, Xiaozhen; Cai, Lu; Tan, Yi] Univ Louisville, Kosair Childrens Hosp, Dept Pediat, Res Inst, Louisville, KY 40202 USA.
   [Wang, Shudong; Zhang, Zhiguo] Jilin Univ, Hosp 1, Ctr Cardiovasc Dis, Changchun 130000, Peoples R China.
   [Luo, Manyu] Jilin Univ, Hosp 2, Dept Nephrol, Changchun 130000, Peoples R China.
   [Dai, Xiaozhen] Chengdu Med Coll, Sch Biomed, Chengdu 610500, Peoples R China.
   [Kong, Maiying] Univ Louisville, Dept Bioinformat & Biostat, SPHIS, Louisville, KY 40202 USA.
   [Wang, Yuehui] Jilin Univ, Dept Geriatr Med, Hosp 1, Changchun 130000, Peoples R China.
C3 Xi'an Jiaotong University; Wenzhou Medical University; Wenzhou Medical
   University; University of Louisville; Jilin University; Jilin
   University; Chengdu Medical College; University of Louisville; Jilin
   University
RP Shi, BY (corresponding author), Xi An Jiao Tong Univ, Sch Med, Affiliated Hosp 1, Dept Endocrinol, Xian 710061, Peoples R China.
EM shibingy@126.com
RI Cai, Lu/AAG-9920-2019
FU Jilin Province Science and Technology Development Project
   [20140519012JH]; National Natural Science Foundation of China [81270293,
   81470061, 81200917, 81573435]; Key Science and Technology Development
   Plan from Wenzhou City [Y20100001]; Key New Drug Development Grants
   [2012ZX09103-301-016]
FX This work was supported in part by grants from Jilin Province Science
   and Technology Development Project (20140519012JH) and the National
   Natural Science Foundation of China (81270293, 81470061, 81200917,
   81573435), and a Key Science and Technology Development Plan from
   Wenzhou City (Y20100001) and a Key New Drug Development Grants
   (2012ZX09103-301-016).
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NR 48
TC 17
Z9 17
U1 0
U2 19
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1096-6080
EI 1096-0929
J9 TOXICOL SCI
JI Toxicol. Sci.
PD SEP
PY 2016
VL 153
IS 1
BP 124
EP 136
DI 10.1093/toxsci/kfw110
PG 13
WC Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Toxicology
GA EA3CH
UT WOS:000386475700012
PM 27370414
OA Bronze
DA 2025-06-11
ER

PT J
AU Li, Y
   Zhang, WZ
   Doughtie, A
   Cui, GZ
   Li, XY
   Pandit, H
   Yang, YB
   Li, SP
   Martin, R
AF Li, Yan
   Zhang, Weizhong
   Doughtie, Anne
   Cui, Guozhen
   Li, Xuanyi
   Pandit, Harshul
   Yang, Yingbin
   Li, Suping
   Martin, Robert
TI Up-regulation of fibroblast growth factor 19 and its receptor associates
   with progression from fatty liver to hepatocellular carcinoma
SO ONCOTARGET
LA English
DT Article
DE hepatocellular carcinoma; FGF19; FGFR4; cancer stem cell
ID CLINICAL CHARACTERISTICS; METABOLIC SYNDROME; EXPRESSION; CANCER;
   PROGNOSIS; DISEASE; FGF19; RECURRENCE; FEATURES; STRESS
AB Background: Human fibroblast growth factor 19 (FGF19), its receptor (FGFR4) and EpCAM play an important role in cell proliferation, differentiation, motility, and overexpression have been linked to hepatocellular carcinoma (HCC). The aim of this study was to evaluate the FGF19 signals responsible for the progression of HCC arising from fatty liver.
   Results: FGF19 level was significantly increased in the HCC patients' serum compared to non-HCC controls. The IHC results demonstrated significant increases of protein expressions of FGF19, FGFR4 and EpCAM in specimens with fatty liver, NASH, cirrhosis, and HCC compared to healthy liver tissue. There was a significant positive correlation between the protein expressions (FGF19, FGFR4, and EpCAM) and histopathologic changes from FL to HCC. Furthermore, FGF19 was positively correlated with FGFR4 and with EpCAM.
   Materials and Methods: FGF19 protein levels in serum and tissues were determined by ELISA assay. The FGFR4, and EpCAM expression and tissue distribution were further evaluated by immunohistochemical staining in tissue array samples. FGF19, FGFR4 and EpCAM expressions between the different histologic stages of fatty liver steatohepatitis-cirrhosis-HCC carcinogenesis sequence were compared to healthy hepatic tissue.
   Conclusions: Overexpression of FGF19/FGFR4 significantly correlated with EpCAM as a marker of hepatic cancer stem cells within the fatty liver-steatosis-cirrhosis-HCC sequence. Impact: This is the first study to elucidate FGF19/FGFR4 signaling in favor of HCC cells developing as indicated by increased EpCAM within the carcinogenesis sequence from fatty liver to hepatocellular carcinoma. Our study has the potential to yield novel and cost effective screening strategies for HCC patients.
C1 [Li, Yan; Doughtie, Anne; Li, Xuanyi; Pandit, Harshul; Yang, Yingbin; Li, Suping; Martin, Robert] Univ Louisville, Sch Med, Div Surg Oncol, Dept Surg, Louisville, KY 40202 USA.
   [Zhang, Weizhong] Jilin Univ, China Japan Union Hosp, Dept Hand Surg, Changchun 130022, Jilin, Peoples R China.
   [Cui, Guozhen] Jilin Univ, Dept Hepatol, Ctr Canc, Hosp 1, Changchun 130021, Peoples R China.
C3 University of Louisville; Jilin University; Jilin University
RP Li, Y; Martin, R (corresponding author), Univ Louisville, Sch Med, Div Surg Oncol, Dept Surg, Louisville, KY 40202 USA.
EM Yan.li@louisville.edu; robert.martin@louisville.edu
RI Guozhen, cui/C-5784-2009; Pandit, Harshul/W-7515-2019; Wang,
   Yahui/JCO-6233-2023
OI Cui, Guozhen/0000-0002-7639-2456
FU American Diabetes Association Basic Science Award [1-13-BS-109]
FX This work was supported partly by the American Diabetes Association
   Basic Science Award Grant #1-13-BS-109.
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NR 39
TC 36
Z9 37
U1 0
U2 13
PU IMPACT JOURNALS LLC
PI ORCHARD PARK
PA 6666 E QUAKER ST, STE 1, ORCHARD PARK, NY 14127 USA
EI 1949-2553
J9 ONCOTARGET
JI Oncotarget
PD AUG 9
PY 2016
VL 7
IS 32
BP 52329
EP 52339
DI 10.18632/oncotarget.10750
PG 11
WC Oncology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Cell Biology
GA DY9CC
UT WOS:000385429100122
PM 27447573
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Fann, JCY
   Lai, HM
   Chiu, SYH
   Yen, AMF
   Chen, SLS
   Chen, HH
AF Fann, Jean Ching-Yuan
   Lai, Hongmin
   Chiu, Sherry Yueh-Hsia
   Yen, Amy Ming-Fang
   Chen, Sam Li-Sheng
   Chen, Hsiu-Hsi
TI A population-based study on the association between the intake of soft
   drinks and periodontal disease in Taiwanese adults aged 35-44 years
   (KCIS no. 33)
SO PUBLIC HEALTH NUTRITION
LA English
DT Article
DE Soft drinks; Periodontal disease; Community periodontal index; Loss of
   attachment
ID BONE-MINERAL DENSITY; METABOLIC SYNDROME; OXIDATIVE STRESS; WOMEN;
   CONSUMPTION; HEALTH; LINK; INFLAMMATION; MODEL
AB Objective: To elucidate the association between the intake of soft drinks and periodontal disease (PD) among Taiwanese middle-aged adults.
   Design: The cross-sectional design was employed to assess a dose-response relationship between the intake of soft drinks and PD after controlling for relevant confounding factors, with adjusted odds ratios obtained from a multivariate logistic regression model.
   Setting: Keelung Community-based Integrated Screening (KCIS) programme, Keelung, Taiwan.
   Subjects: Participants (n 10 213) aged 35-44 years who had undergone oral checks for PD between 2005 and 2009.
   Results: A dose-response relationship between the intake of soft drinks and elevated risk for PD defined by community periodontal index <= 3 (the current status of PD) was noted (P= 0.02 by trend test). Compared with infrequent intake of soft drinks (<= 2 times/week), the adjusted OR increased from 1.05 (95 % CI 0.92, 1.20) for the frequency of 3-4 times/week to 1.17 (95 % CI 1.03, 1.34) for the frequency of = 5 times/week. A similar trend (P < 0.01) was also observed for PD defined by loss of attachment <= 1 (representing the long-term cumulative gum damage due to PD).
   Conclusions: A dose-response relationship between the intake frequency of soft drinks and PD was observed in Taiwanese middle-aged adults. Such evidence could be used in health promotion to support reductions in soft drink intake.
C1 [Fann, Jean Ching-Yuan] Kainan Univ, Coll Healthcare Management, Dept Hlth Ind Management, Taoyuan, Taiwan.
   [Lai, Hongmin] QC Dent Clin, Taipei, Taiwan.
   [Lai, Hongmin] Natl Yang Ming Univ, Dept Dent, Taipei, Taiwan.
   [Lai, Hongmin; Yen, Amy Ming-Fang; Chen, Sam Li-Sheng] Taipei Med Univ, Coll Oral Med, Sch Oral Hyg, Taipei, Taiwan.
   [Chiu, Sherry Yueh-Hsia] Chang Gung Univ, Coll Management, Dept Hlth Care Management, Taoyuan, Taiwan.
   [Chen, Hsiu-Hsi] Natl Taiwan Univ, Coll Publ Hlth, Grad Inst Epidemiol & Prevent Med, Div Biostat, Room 533,17 Hsuchow Rd, Taipei 100, Taiwan.
C3 Nan Kai University Technology; National Yang Ming Chiao Tung University;
   Taipei Medical University; Chang Gung University; National Taiwan
   University
RP Chen, HH (corresponding author), Natl Taiwan Univ, Coll Publ Hlth, Grad Inst Epidemiol & Prevent Med, Div Biostat, Room 533,17 Hsuchow Rd, Taipei 100, Taiwan.
EM chenlin@ntu.edu.tw
RI Hsu, Chien-Ning/GLS-4014-2022
OI Chiu, Sherry Yueh-Hsia/0000-0002-7207-7088; Chen, Tony
   Hsiu-Hsi/0000-0002-5799-6705
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NR 33
TC 16
Z9 16
U1 0
U2 1
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 1368-9800
EI 1475-2727
J9 PUBLIC HEALTH NUTR
JI Public Health Nutr.
PD JUN
PY 2016
VL 19
IS 8
BP 1471
EP 1478
DI 10.1017/S1368980015002608
PG 8
WC Public, Environmental & Occupational Health; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health; Nutrition & Dietetics
GA DS6NJ
UT WOS:000380898400015
PM 26349995
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Geng, TY
   Sutter, A
   Harland, MD
   Law, BA
   Ross, JS
   Lewin, D
   Palanisamy, A
   Russo, SB
   Chavin, KD
   Cowart, LA
AF Geng, Tuoyu
   Sutter, Alton
   Harland, Michael D.
   Law, Brittany A.
   Ross, Jessica S.
   Lewin, David
   Palanisamy, Arun
   Russo, Sarah B.
   Chavin, Kenneth D.
   Cowart, L. Ashley
TI SphK1 mediates hepatic inflammation in a mouse model of NASH induced by
   high saturated fat feeding and initiates proinflammatory signaling in
   hepatocytes
SO JOURNAL OF LIPID RESEARCH
LA English
DT Article
DE sphingolipids; liver, diet and dietary lipids; lipid kinases;
   steatohepatitis; sphingosine-1-phosphate; lipotoxicity; sphingosine
   kinase 1; nonalcoholic steatohepatitis; nonalcoholic fatty liver disease
ID SPHINGOSINE KINASE 1; PERFORMANCE LIQUID-CHROMATOGRAPHY;
   INSULIN-RESISTANCE; LIVER-DISEASE; SPHINGOLIPID METABOLISM;
   ENDOTHELIAL-CELLS; RETICULUM STRESS; ACTIVATION; ACIDS; MICE
AB Steatohepatitis occurs in up to 20% of patients with fatty liver disease and leads to its primary disease outcomes, including fibrosis, cirrhosis, and increased risk of hepatocellular carcinoma. Mechanisms that mediate this inflammation are of major interest. We previously showed that overload of saturated fatty acids, such as that which occurs with metabolic syndrome, induced sphingosine kinase 1 (SphK1), an enzyme that generates sphingosine-1-phosphate (S1P). While data suggest beneficial roles for S1P in some contexts, we hypothesized that it may promote hepatic inflammation in the context of obesity. Consistent with this, we observed 2-fold elevation of this enzyme in livers from humans with nonalcoholic fatty liver disease and also in mice with high saturated fat feeding, which recapitulated the human disease. Mice exhibited activation of NF kappa B, elevated cytokine production, and immune cell infiltration. Importantly, SphK1-null mice were protected from these outcomes. Studies in cultured cells demonstrated saturated fatty acid induction of SphK1 message, protein, and activity, and also a requirement of the enzyme for NF kappa B signaling and increased mRNA encoding TNF alpha and MCP1. Moreover, saturated fat-induced NF kappa B signaling and elevation of TNF alpha and MCP1 mRNA in HepG2 cells was blocked by targeted knockdown of S1P receptor 1, supporting a role for this lipid signaling pathway in inflammation in nonalcoholic fatty liver disease.
C1 [Geng, Tuoyu; Harland, Michael D.; Law, Brittany A.; Ross, Jessica S.; Russo, Sarah B.; Cowart, L. Ashley] Med Univ S Carolina, Dept Biochem & Mol Biol, Charleston, SC 29425 USA.
   [Sutter, Alton; Palanisamy, Arun; Chavin, Kenneth D.] Med Univ S Carolina, Dept Surg, Charleston, SC 29425 USA.
   [Lewin, David] Med Univ S Carolina, Dept Pathol & Lab Med, Charleston, SC 29425 USA.
   [Law, Brittany A.; Cowart, L. Ashley] Ralph H Johnson Vet Affairs Med Ctr, Charleston, SC 29403 USA.
C3 Medical University of South Carolina; Medical University of South
   Carolina; Medical University of South Carolina; US Department of
   Veterans Affairs; Veterans Health Administration (VHA); Ralph H Johnson
   VA Medical Center
RP Cowart, LA (corresponding author), Med Univ S Carolina, Dept Biochem & Mol Biol, Charleston, SC 29425 USA.
EM cowartl@musc.edu
RI Cowart, Lauren/KUC-8358-2024; Chavin, Kenneth/JXN-5061-2024; Sutter,
   Alton/GWV-3369-2022; Palanisamy, Arun/I-7712-2019; Cowart,
   Lauren/F-2375-2017
OI Cowart, Lauren/0000-0002-5312-5232; Chavin, Kenneth
   D/0000-0003-0818-4847; Elliott, Brittany/0000-0001-5907-1231
FU Veterans Affairs Merit Award; National Institutes of Health
   [1R01HL117233, 5P30GM103339-03, 1R01DK069369]
FX This work was supported by a Veterans Affairs Merit Award, National
   Institutes of Health Grants 1R01HL117233 and 5P30GM103339-03 (L.A.C.),
   and National Institutes of Health Grant 1R01DK069369 to K.D.C. The
   authors acknowledge that there are no conflicts of interest to disclose.
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NR 41
TC 74
Z9 80
U1 0
U2 18
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0022-2275
EI 1539-7262
J9 J LIPID RES
JI J. Lipid Res.
PD DEC
PY 2015
VL 56
IS 12
BP 2359
EP 2371
DI 10.1194/jlr.M063511
PG 13
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA CX6XA
UT WOS:000365843800012
PM 26482537
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Bleil, ME
   Appelhans, BM
   Latham, MD
   Irving, MA
   Gregorich, SE
   Adler, NE
   Cedars, MI
AF Bleil, Maria E.
   Appelhans, Bradley M.
   Latham, Melissa D.
   Irving, Michelle A.
   Gregorich, Steven E.
   Adler, Nancy E.
   Cedars, Marcelle I.
TI Neighborhood Socioeconomic Status During Childhood Versus Puberty in
   Relation to Endogenous Sex Hormone Levels in Adult Women
SO NURSING RESEARCH
LA English
DT Article
DE cardiovascular disease; early life adversity; life course; puberty; sex
   hormones; socioeconomic status
ID EARLY-LIFE STRESS; CHRONIC DISEASE EPIDEMIOLOGY; INCIDENT METABOLIC
   SYNDROME; CAUSE-SPECIFIC MORTALITY; CORONARY-HEART-DISEASE; AGE-RELATED
   DISEASE; BETA-CELL FUNCTION; BINDING GLOBULIN; CARDIOVASCULAR-DISEASE;
   BLOOD-PRESSURE
AB Background: Socioeconomic adversity in early life is related to cardiovascular risk in adulthood; however, no studies have examined whether such adversity may be related to endogenous sex hormones, which are themselves associated with cardiovascular outcomes, or whether the timing of adversity exposures (childhood vs. puberty) matters.
   Objective: The goal of the current study was to separately examine neighborhood socioeconomic status (SES) during periods of childhood and puberty in relation to adulthood levels of endogenous sex hormones (estradiol [E-2], testosterone), sex hormone binding globulin (SHBG), and a derived index of bioavailable testosterone (free androgen index).
   Methods: In a sample of 143 premenopausal women (mean age = 36.8 [ SD = 5.5]; 51.7% White, 32.2% African American, 5.6% Latina, 7.0% Chinese, and 3.5% Filipina), retrospective reports of residential address information in designated periods of childhood and puberty were used to derive U.S. census-based neighborhood SES composite scores characterizing the socioeconomic environments of women during these periods.
   Results: In covariate-adjusted analyses, higher neighborhood SES in puberty predicted higher levels of SHBG in adulthood, but neighborhood SES during childhood did not (standardized regression coefficient = .24, p = .01 vs. standardized regression coefficient = .04, p = .75, respectively). Neighborhood SES was not predictive of other hormones (E-2, testosterone, and free androgen index).
   Discussion: The current findings suggest that puberty may be a time of particular vulnerability to the effects of neighborhood SES on SHBG levels, which have been linked to cardiovascular risk factor profiles and atherosclerotic disease progression.
C1 [Bleil, Maria E.] Univ Washington, Dept Family & Child Nursing, Seattle, WA 98195 USA.
   [Appelhans, Bradley M.] Rush Univ, Med Ctr, Dept Prevent Med, Chicago, IL 60612 USA.
   [Latham, Melissa D.; Irving, Michelle A.; Adler, Nancy E.] Univ Calif San Francisco, Dept Psychiat, San Francisco, CA USA.
   [Gregorich, Steven E.] Univ Calif San Francisco, Dept Med, San Francisco, CA USA.
   [Cedars, Marcelle I.] Univ Calif San Francisco, Dept Obstet Gynecol & Reprod Sci, San Francisco, CA USA.
C3 University of Washington; University of Washington Seattle; Rush
   University; University of California System; University of California
   San Francisco; University of California System; University of California
   San Francisco; University of California System; University of California
   San Francisco
RP Bleil, ME (corresponding author), Univ Washington, Dept Family & Child Nursing, Box 357262, Seattle, WA 98195 USA.
EM mbleil@uw.edu
RI Adler, Nancy/ABR-3334-2022
OI Irving, Michelle/0000-0002-0664-4523
FU NIH/NICHD; NIH/NIA [R01 HD044876, K08 AG03575]; NIH/UCSF-CTSI [UL1
   RR024131]; Robert Wood Johnson Foundation [045820]
FX The authors acknowledge preparation of this manuscript and the research
   described here were supported by NIH/NICHD and NIH/NIA (R01 HD044876),
   NIH/NIA (K08 AG03575), NIH/UCSF-CTSI (UL1 RR024131), and the Robert Wood
   Johnson Foundation (045820). The funders had no involvement in the
   execution of the study, data analyses, or manuscript preparation.
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NR 57
TC 14
Z9 14
U1 0
U2 18
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0029-6562
EI 1538-9847
J9 NURS RES
JI Nurs. Res.
PD MAY-JUN
PY 2015
VL 64
IS 3
BP 211
EP 220
DI 10.1097/NNR.0000000000000096
PG 10
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA CH1NI
UT WOS:000353788100007
PM 25932699
OA Green Accepted, Green Submitted
DA 2025-06-11
ER

PT J
AU Reyes, M
   Quintanilla, C
   Burrows, R
   Blanco, E
   Cifuentes, M
   Gahagan, S
AF Reyes, Marcela
   Quintanilla, Cristina
   Burrows, Raquel
   Blanco, Estela
   Cifuentes, Mariana
   Gahagan, Sheila
TI Obesity is associated with acute inflammation in a sample of adolescents
SO PEDIATRIC DIABETES
LA English
DT Article
DE acute inflammation; adolescents; leukocytes; neutrophils; obesity
ID BLOOD-CELL COUNT; CORONARY-HEART-DISEASE; SYSTEMIC INFLAMMATION;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; LEPTIN; OVERWEIGHT; NEUTROPHILS;
   ACTIVATION; STRESS
AB BackgroundObesity is associated with a mild chronic inflammatory response, which has been suggested to be pivotal in the development of cardiometabolic alterations of obesity. However, little is known about the involvement of acute inflammation.
   ObjectiveTo evaluate whether circulating neutrophils, markers of acute inflammation, are associated (quantitatively and qualitatively) with adolescent obesity and whether leptin modulates these associations.
   Subjects and methodsWe assessed 528 adolescents (16.8 yr old, 47% females), without chronic/acute illness. We measured anthropometry and dual energy X-ray absorptiometry and calculated fat mass percentage (FM%). Fasting serum glucose, high-density lipoprotein (HDL)-cholesterol, and triglycerides were used with blood pressure and waist circumference to compute a metabolic z-score. Leukocyte and neutrophil counts were obtained, together with levels of serum leptin. In a subsample of 23 males, flow cytometry was used to assess degranulation (CD66b expression) of neutrophils.
   ResultsFemale sex and obesity were positively related to mean neutrophil counts (p < 0.05). When accounting for sex and weight status, leptin was associated with neutrophil counts (p < 0.05), partially explaining the association between obesity and neutrophil counts. Neutrophil counts were related to metabolic risk z-scores, controlling for fat mass. Participants with elevated FM% showed more neutrophil degranulation than controls (p < 0.05).
   ConclusionsParticipants with increased adiposity had higher circulating neutrophil counts, suggesting acute inflammation. Furthermore, the neutrophils showed more degranulation, indicating inflammation. Obesity-induced alteration of the adipose secretory pattern (i.e., changes in leptin levels) could be involved in acute inflammation.
C1 [Reyes, Marcela; Quintanilla, Cristina; Burrows, Raquel; Cifuentes, Mariana] Univ Chile, Inst Nutr & Food Technol INTA, Publ Hlth Unit, Santiago 7830489, Chile.
   [Blanco, Estela; Gahagan, Sheila] Univ Calif San Diego, Dept Pediat, Div Child Dev & Community Hlth, La Jolla, CA 92093 USA.
   [Gahagan, Sheila] Univ Michigan, Ctr Human Growth & Dev, Ann Arbor, MI 48109 USA.
C3 Universidad de Chile; University of California System; University of
   California San Diego; University of Michigan System; University of
   Michigan
RP Reyes, M (corresponding author), Univ Chile, Inst Nutr & Food Technol INTA, Publ Hlth Unit, El Libano 5524, Santiago 7830489, Chile.
EM mreyes@inta.uchile.cl
RI Burrows, Raquel/A-8489-2015; Blanco, Estela/A-2541-2014; Cifuentes,
   Mariana/I-1054-2013; Reyes, Marcela/A-6247-2013
OI Blanco, Estela/0000-0002-6232-9210; Cifuentes,
   Mariana/0000-0001-9485-3490; Reyes, Marcela/0000-0002-4601-7663;
   Gahagan, Sheila/0000-0002-1105-7323
FU National Institutes of Health, Heart, Lung, and Blood Institute
   [HL088530]; Nevin Scrimshaw International Nutrition Foundation
FX We thank all participants and their families for their trust and ongoing
   participation; we also thank the research and health professionals
   involved in the assessments and laboratory analysis. This study was
   supported by grants from the National Institutes of Health, Heart, Lung,
   and Blood Institute (HL088530, PI: Gahagan), and the Nevin Scrimshaw
   International Nutrition Foundation (Re-entry fellowship, PI: Reyes). The
   content is solely the responsibility of the authors and does not
   necessarily represent the official views of the founding Institutions.
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NR 41
TC 21
Z9 22
U1 0
U2 9
PU WILEY-HINDAWI
PI LONDON
PA ADAM HOUSE, 3RD FL, 1 FITZROY SQ, LONDON, WIT 5HE, ENGLAND
SN 1399-543X
EI 1399-5448
J9 PEDIATR DIABETES
JI Pediatr. Diabetes
PD MAR
PY 2015
VL 16
IS 2
BP 109
EP 116
DI 10.1111/pedi.12129
PG 8
WC Endocrinology & Metabolism; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Pediatrics
GA CC1KP
UT WOS:000350099900006
PM 24636574
OA Green Accepted, gold, Green Published
DA 2025-06-11
ER

PT J
AU Orban, E
   Schwab, S
   Thorand, B
   Huth, C
AF Orban, Ester
   Schwab, Sigrid
   Thorand, Barbara
   Huth, Cornelia
TI Association of iron indices and type 2 diabetes: a meta-analysis of
   observational studies
SO DIABETES-METABOLISM RESEARCH AND REVIEWS
LA English
DT Review
DE type 2 diabetes; iron; ferritin; transferrin; soluble transferrin
   receptor
ID SOLUBLE TRANSFERRIN RECEPTOR; SERUM FERRITIN; INSULIN-RESISTANCE;
   OXIDATIVE STRESS; METABOLIC SYNDROME; NATIONAL-HEALTH; STORES; RISK;
   MELLITUS; SATURATION
AB The literature on the role of body iron status in the development of type 2 diabetes (T2D) in humans is inconsistent. We aimed to assess the association between iron indices and T2D by ameta-analysis of previously published studies. A systematic literature search was conducted in PubMed and EMBASE. Observational studies on the association of ferritin (when controlled for age and sex), transferrin saturation, soluble transferrin receptor and transferrin with T2D were included. Pooled association estimates were calculated using a random effects model. Forty-six eligible studies were identified. The pooled multivariable adjusted relative risks of T2D in the highest versus lowest quartile of ferritin levels were significantly elevated in both cross-sectional as well as prospective studies and after restriction to inflammation-adjusted studies [overall: 1.67 (95% CI 1.41-1.99)]. The mean difference indicated 43.54 ng/mL (95% CI 28.14-58.94) higher ferritin levels in type 2 diabetic individuals. The relative risk for a transferrin saturation >= 50% was 1.59 (95% CI 1.28-1.97), the mean difference was -1.92% [95% CI -2.99-(-0.85)]. Study-specific results of soluble transferrin receptor and transferrin levels were extremely heterogeneous. Ferritin and clinically elevated transferrin saturation were strongly associated with an increased risk of T2D, overall and in prospective studies. Ferritin was also significantly associated after multivariable adjustment including inflammation. Thus, the current evidence hints at a causal effect; however, publication bias and unmeasured confounding cannot be excluded. Copyright (C) 2013 John Wiley & Sons, Ltd.
C1 [Orban, Ester; Schwab, Sigrid; Thorand, Barbara; Huth, Cornelia] Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Epidemiol 2, DE-85764 Neuherberg, Germany.
   [Orban, Ester; Thorand, Barbara; Huth, Cornelia] German Ctr Diabet Res DZD, Neuherberg, Germany.
C3 Helmholtz Association; Helmholtz-Center Munich - German Research Center
   for Environmental Health; German Center for Diabetes Research (DZD)
RP Huth, C (corresponding author), Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Epidemiol 2, Ingolstaedter Landstr 1, DE-85764 Neuherberg, Germany.
EM huth@helmholtz-muenchen.de
RI Thorand, Barbara/B-5349-2014; Huth, Cornelia/B-5350-2014
OI Huth, Cornelia/0000-0003-2421-433X; Orban, Ester/0000-0001-5634-277X
FU German Federal Ministry of Education and Research (BMBF)
FX We thank all authors that contributed data or additional information
   about their studies. We also thank Dr Jens Baumert, Helmholtz Zentrum
   Munchen, for his statistical advice. C. H. is supported by a grant from
   the German Federal Ministry of Education and Research (BMBF) to the
   German Center for Diabetes Research e.V. (DZD).
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NR 80
TC 71
Z9 73
U1 1
U2 22
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1520-7552
EI 1520-7560
J9 DIABETES-METAB RES
JI Diabetes-Metab. Res. Rev.
PD JUL
PY 2014
VL 30
IS 5
BP 372
EP 394
DI 10.1002/dmrr.2506
PG 23
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA AL8VD
UT WOS:000339416900005
PM 24327370
DA 2025-06-11
ER

PT J
AU Dagenais, M
   Skeldon, A
   Saleh, M
AF Dagenais, M.
   Skeldon, A.
   Saleh, M.
TI The inflammasome: in memory of Dr. Jurg Tschopp
SO CELL DEATH AND DIFFERENTIATION
LA English
DT Review
DE inflammasome; sterile inflammation; metabolism
ID NF-KAPPA-B; FAMILIAL MEDITERRANEAN FEVER; INNATE IMMUNE-RESPONSES; NALP3
   INFLAMMASOME; NLRP3 INFLAMMASOME; CELL-DEATH; CASPASE-1 ACTIVATION;
   INTERLEUKIN-1-BETA GENERATION; IL-1-BETA SECRETION; INSULIN-RESISTANCE
AB A decade ago, Jurg Tschopp introduced the concept of the inflammasome. This exciting discovery of a macromolecular complex that senses 'danger' and initiates the inflammatory response contributed to a renaissance in the fields of innate immunity and cell death. Jurg led the biochemical characterization of the inflammasome complex and demonstrated that spontaneous hyperactivation of this interleukin (IL)-1 beta processing machinery is the molecular basis of a spectrum of hereditary periodic fever syndromes, caused by mutated forms of the inflammasome scaffolding receptor, NLRP3. The identification of the underlying mechanism in these disorders has led to their now successful therapy, with the use of the IL-1 receptor antagonist in the clinic. Jurg's pioneering work has subsequently defined a number of inflammasome agonists ranging from microbial molecules expressed during infection, to triggers of sterile inflammation, most notably gout-associated uric acid crystals, asbestos, silica and nanoparticles. More recently, Jurg introduced the critical new concept of the metabolic inflammasome, which senses metabolic stress and contributes to the onset of the metabolic syndrome associated with obesity and type 2 diabetes. Jurg was an outstanding and skillful biochemist, an elegant and rigorous researcher often far ahead of his peers. He was a truly amiable person, fair, generous and inspiring, and will be most remembered for his infectious enthusiasm. We write this review article on the inflammasome in his honor and dedicate it to his memory. Cell Death and Differentiation (2012) 19, 5-12; doi:10.1038/cdd.2011.159; published online 11 November 2011
C1 [Dagenais, M.; Skeldon, A.; Saleh, M.] McGill Univ, Dept Biochem, Montreal, PQ, Canada.
   [Saleh, M.] McGill Univ, Dept Med, Montreal, PQ, Canada.
C3 McGill University; McGill University
RP Saleh, M (corresponding author), McGill Life Sci Complex,Room 364,3649 Promenade S, Montreal, PQ H3G 0B1, Canada.
EM maya.saleh@mcgill.ca
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NR 88
TC 75
Z9 84
U1 0
U2 20
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1350-9047
EI 1476-5403
J9 CELL DEATH DIFFER
JI Cell Death Differ.
PD JAN
PY 2012
VL 19
IS 1
BP 5
EP 12
DI 10.1038/cdd.2011.159
PG 8
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA 866GR
UT WOS:000298369000002
PM 22075986
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Williams, ED
   Steptoe, A
   Chambers, JC
   Kooner, JS
AF Williams, Emily D.
   Steptoe, Andrew
   Chambers, John C.
   Kooner, Jaspal S.
TI Ethnic and Gender Differences in the Relationship Between Hostility and
   Metabolic and Autonomic Risk Factors for Coronary Heart Disease
SO PSYCHOSOMATIC MEDICINE
LA English
DT Article
DE hostility; coronary heart disease; risk factors; ethnic differences;
   gender
ID BLOOD-PRESSURE; CARDIOVASCULAR REACTIVITY; PHYSIOLOGICAL-RESPONSES;
   PSYCHOSOCIAL FACTORS; SEX-DIFFERENCES; PREDICT; STRESS; ANGER; MEN;
   ASSOCIATION
AB Objective: To examine the relationship between hostility and biological risk factors for coronary heart disease (CUD) in a population of white European and South Asian men and women living in the United Kingdom. Methods: This cross-sectional study involved a community-based sample of 1,757 healthy white and South Asian men and women aged between 35 years and 75 years from West London. Participants completed the Cook-Medley Hostility Scale, together with measures of standard biological risk factors and heart rate variability. Associations between hostility and CHD risk factors were evaluated, controlling for age, education, smoking, physical activity, body mass index, and waist/hip ratio, using regression models. Results: In white men, hostility was associated positively with fasting glucose, glycosylated hemoglobin, and negatively with high-density lipoprotein cholesterol. High levels of hostility were also related to increased prevalence of diabetes and the metabolic syndrome in white men. Hostility in South Asian men was associated with impaired autonomic function. Hostility was not related to any biological CHD risk factors in South Asian or white women. Conclusions: Our results showed that hostility was independently associated with glucose metabolism and dyslipidemia in white men, and with autonomic dysfunction in South Asian men. Hostility was found not to be relevant for measured CHD risk factors in females. Longitudinal data are required to establish whether the impact of hostility on CHD risk in men is mediated through metabolic and autonomic processes.
C1 [Williams, Emily D.; Steptoe, Andrew] UCL, Dept Epidemiol & Publ Hlth, Psychobiol Grp, London WC1E 6BT, England.
   [Chambers, John C.; Kooner, Jaspal S.] Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, London, England.
C3 University of London; University College London; Imperial College London
RP Williams, ED (corresponding author), UCL, Dept Epidemiol & Publ Hlth, Psychobiol Grp, 1-19 Torrington Pl, London WC1E 6BT, England.
EM emily.williams@ucl.ac.uk
RI Steptoe, Andrew/Y-2440-2019; Chambers, John/KLB-9915-2024
OI Williams, Emily/0000-0002-9399-1960; Steptoe, Andrew/0000-0001-7808-4943
FU British Heart Foundation; Economic and Social Research Council; Medical
   Research Council; MRC [G0700931, G0601966] Funding Source: UKRI
FX This study was supported, in part, by the British Heart Foundation
   (E.W., A.S.), the Economic and Social Research Council (E.W.), and the
   Medical Research Council (E.W.).
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NR 36
TC 21
Z9 21
U1 0
U2 12
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0033-3174
EI 1534-7796
J9 PSYCHOSOM MED
JI Psychosom. Med.
PD JAN
PY 2011
VL 73
IS 1
BP 53
EP 58
DI 10.1097/PSY.0b013e3181fd944c
PG 6
WC Psychiatry; Psychology; Psychology, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry; Psychology
GA 711BZ
UT WOS:000286562000007
PM 20947780
DA 2025-06-11
ER

PT J
AU Sonnett, TE
   Levien, TL
   Gates, BJ
   Robinson, JD
   Campbell, RK
AF Sonnett, Travis E.
   Levien, Terri L.
   Gates, Brian J.
   Robinson, Jennifer D.
   Campbell, R. Keith
TI Diabetes Mellitus, Inflammation, Obesity: Proposed Treatment Pathways
   for Current and Future Therapies
SO ANNALS OF PHARMACOTHERAPY
LA English
DT Article
DE adiponectin; diabetes mellitus; ghrelin; leptin; resveratrol
ID PLASMA ADIPONECTIN LEVELS; GHRELIN RECEPTOR AGONIST; INSULIN-RESISTANCE;
   METABOLIC SYNDROME; PPAR-GAMMA; GASTROINTESTINAL MOTILITY; PROTEIN
   ADIPONECTIN; GLUCOSE-HOMEOSTASIS; OXIDATIVE STRESS; SIRT1 ACTIVATION
AB OBJECTIVE: To review the pathophysiology, pharmacology, and current or future therapies under study for use in treating diabetes mellitus, inflammation associated with diabetes mellitus, and/or obesity related to diabetes mellitus, through 1 of 4 investigational pathways: adiponectin, ghrelin, resveratrol, or leptin.
   DATA SOURCES: A literature search using MEDLINE (1966 December 12, 2009), Pub Med (1950 December 12, 2009), Science Direct (1994 December 12, 2009), and International Pharmaceutical Abstracts (1970 December 12, 2009) was performed using the terms adiponectin, ghrelin, resveratrol, leptin, inflammation, obesity, and diabetes mellitus. English-language, original research, and review articles were examined, and citations from these articles were assessed as well.
   STUDY SELECTION AND DATA EXTRACTION: Clinical studies and in vitro studies were included in addition to any Phase 1, 2, or 3 clinical trials.
   DATA SYNTHESIS: Mechanistic pathways regarding adiponectin, ghrelin, resveratrol, and leptin are of interest as future treatment options for diabetes mellitus. Each of these pathways has produced significant in vitro and in vivo clinical data warranting further research as a possible treatment pathway for diabetes-related inflammation and/or obesity reduction. While research is still underway to determine the exact effects these pathways have on metabolic function, current data suggest that each of these compounds may be of interest for future therapies.
   CONCLUSIONS: While several pathways under investigation may offer additional benefits in the treatment of diabetes mellitus and associated impairments, further investigation is necessary for both investigational and approved therapies to ensure that the impact in new pathways does not increase risks to patient safety and outcomes.
C1 [Sonnett, Travis E.; Robinson, Jennifer D.; Campbell, R. Keith] Washington State Univ, Dept Pharmacotherapy, Coll Pharm, Pullman, WA 99164 USA.
   [Levien, Terri L.; Gates, Brian J.] Washington State Univ, Dept Pharmacotherapy, Coll Pharm, Spokane, WA USA.
C3 Washington State University; Washington State University
RP Sonnett, TE (corresponding author), Washington State Univ, Dept Pharmacotherapy, Coll Pharm, POB 646510, Pullman, WA 99164 USA.
EM tsonnett@wsu.edu
RI Levien, Terri/U-6011-2019
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NR 125
TC 20
Z9 23
U1 0
U2 13
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1060-0280
EI 1542-6270
J9 ANN PHARMACOTHER
JI Ann. Pharmacother.
PD APR
PY 2010
VL 44
IS 4
BP 701
EP 711
DI 10.1345/aph.1M640
PG 11
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 582EH
UT WOS:000276578400010
PM 20233909
DA 2025-06-11
ER

PT J
AU Yamagishi, SI
   Matsui, T
   Nakamura, K
AF Yamagishi, S. -I.
   Matsui, T.
   Nakamura, K.
TI Possible molecular mechanisms by which angiotensin II type 1 receptor
   blockers (ARBs) prevent the development of atrial fibrillation in
   insulin resistant patients
SO HORMONE AND METABOLIC RESEARCH
LA English
DT Review
DE atrial fibrillation; angiotensin II type 1 receptor blockers; insulin
   resistance; oxidative stress; PPAR-gamma
ID CONVERTING-ENZYME-INHIBITORS; HEART-FAILURE; DIABETES-MELLITUS; SINUS
   RHYTHM; TELMISARTAN; SYSTEM; ANTAGONIST; LOSARTAN; HYPERTENSION;
   CANDESARTAN
AB Atrial fibrillation (AF) is the most common disorder of cardiac rhythm and is responsible for Substantial morbidity and mortality in general population. A recent community-based observational study revealed that diabetes and/or hypertension were associated with the development of AF. However, there is no definite evidence to show that patients with type I diabetes have an increased risk for the development of AF. These findings suggest that hyperglycemia per se may not explain the positive association between diabetes and AF. Growing body of evidence supports the presence of insulin resistance as the fundamental pathophysiological disturbance responsible for the metabolic syndrome, a constellation of metabolic disorders such as hypertension, dyslipidemia, and obesity that raise the risk for diabetes mellitus and cardiovascular diseases. Further, several clinical trials have shown that the renin-angiotensin system (RAS) plays an important role in the pathogenesis of insulin resistance. These observations suggest that insulin resistance could account for the increased risk for AF in the patients with diabetes and/or hypertension and that the interruption of the RAS may be a promising therapeutic strategy for preventing the development of AF In the first part of this paper, we review clinical Studies to Support the concept that angiotensin II type I receptor blockers (ARBs) could prevent the development of AF in insulin resistant patients and discuss the possible underlying mechanisms. In the second part, we discuss the potential utility of telmisartan, a unique ARB with peroxisome proliferator-activated receptor-gamma (PPAR-gamma)-modulating activity, for blocking the development of AF in patients with insulin resistance.
C1 [Yamagishi, S. -I.; Matsui, T.; Nakamura, K.] Kurume Univ, Sch Med, Dept Med, Div Cardiovasc Med, Kurume, Fukuoka 8300011, Japan.
C3 Kurume University
RP Yamagishi, SI (corresponding author), Kurume Univ, Sch Med, Dept Med, Div Cardiovasc Med, Kurume, Fukuoka 8300011, Japan.
EM shoichi@med.kurume-u.ac.jp
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NR 58
TC 18
Z9 19
U1 0
U2 1
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0018-5043
EI 1439-4286
J9 HORM METAB RES
JI Horm. Metab. Res.
PD SEP
PY 2008
VL 40
IS 9
SI SI
BP 640
EP 644
DI 10.1055/s-0028-1083811
PG 5
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 358OK
UT WOS:000259927200009
PM 18792876
DA 2025-06-11
ER

PT J
AU Shehab-Eldin, W
   Shoker, A
AF Shehab-Eldin, Walid
   Shoker, Ahmed
TI Predictors of new onset of diabetes after transplantation in stable
   renal recipients
SO NEPHRON CLINICAL PRACTICE
LA English
DT Article
DE insulin resistance; new onset of diabetes after transplantation; renal
   transplant
ID BETA-CELL DYSFUNCTION; KIDNEY-TRANSPLANTATION; ALLOGRAFT RECIPIENTS;
   INSULIN-RESISTANCE; RISK-FACTORS; METABOLIC SYNDROME; GLUCOSE-TOLERANCE;
   CENTER EXPERIENCE; OXIDATIVE STRESS; MELLITUS
AB Background: Several groups identified pre-transplant factors which contribute to the development of new onset of diabetes after transplantation (NODAT). Aim: To identify post-transplant risk factors for NODAT. Methods: 55 stable renal transplant patients were divided into group A of 34 recipients with normoglycemia and group B of 21 recipients with impaired fasting glucose. Markers including insulin, pro-insulin, soluble receptors for advanced glycated end products (sRAGE), adiponectin, malondialdehyde, homeostasis model assessment of insulin resistance (HOMA-IR), and beta-cell function were calculated at the outset and correlated, thereafter, with the later development of NODAT after a follow-up duration of 14.98 +/- 8 3.97 months. Results: 11.8 and 19% of groups A and B respectively developed NODAT. Insulin, sRAGE, HOMA-IR and basal fasting plasma glucose correlated with the development of NODAT in univariate analysis. A baseline insulin level of 54.54 mU/l predicted the development of NODAT with a specificity of 95.45% and was the only significant factor in the multivariate analysis. beta-Cell function was not different among the three groups. Conclusions: A long prodrome of insulin resistance (IR) exists prior to development of NODAT. 50% of patients with NODAT will remit to a normoglycemic state. IR, rather than beta-cell dysfunction, precedes the development of NODAT. Serum insulin in stable non-diabetic renal transplant patients can be used as a confirmatory test to the development of future NODAT. Copyright (C) 2008 S. Karger AG, Basel.
C1 [Shehab-Eldin, Walid; Shoker, Ahmed] Univ Saskatchewan, Dept Med, Div Nephrol, Royal Univ Hosp, Saskatoon, SK S7N 0W8, Canada.
C3 University of Saskatchewan
RP Shoker, A (corresponding author), Univ Saskatchewan, Dept Med, Div Nephrol, Transplant Program, 103 Hosp Dr, Saskatoon, SK S7N 0W8, Canada.
EM shoker@sask.usask.ca
RI Shehabeldin, Walid/AAJ-1875-2021
OI Shehab-Eldin, Walid/0000-0002-4736-9310
CR [Anonymous], 2007, Diabetes care, V30
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NR 34
TC 11
Z9 11
U1 0
U2 5
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1660-2110
J9 NEPHRON CLIN PRACT
JI Nephron. Clin. Pract.
PY 2008
VL 110
IS 1
BP C1
EP C9
DI 10.1159/000148207
PG 9
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 354TC
UT WOS:000259660900001
PM 18654089
DA 2025-06-11
ER

PT J
AU Oh, H
   Cho, AR
   Jeon, JH
   Suh, E
   Moon, J
   Cho, BH
   Lee, YK
AF Oh, Hyoju
   Cho, A-Ra
   Jeon, Joo-Hwan
   Suh, Eunkyung
   Moon, Junhyung
   Cho, Baek Hwan
   Lee, Yun-Kyong
TI Association between resting heart rate and low natural killer cell
   activity: a cross-sectional study
SO FRONTIERS IN IMMUNOLOGY
LA English
DT Article
DE RESTING HEART RATE; cortisol; natural killer cell; natural killer cell
   activity; immunity
ID AUTONOMIC NERVOUS-SYSTEM; METABOLIC SYNDROME; RATE-VARIABILITY;
   BLOOD-PRESSURE; MORTALITY; ADULTS; RISK; METAANALYSIS; THERAPY; DISEASE
AB Resting heart rate (RHR), a simple physiological indicator, has been demonstrated to be associated with inflammation and even metabolic disorders. This study aimed to investigate whether RHR is associated with natural killer cell activity (NKA) in a large population of healthy adults using a novel assay to measure NKA. This cross-sectional study included 7,500 subjects in the final analysis. NKA was estimated by measuring the amount of interferon-gamma (IFN-gamma) released by activated natural killer cells; low NKA was defined as IFN-gamma level <500 pg/mL. Subjects were categorized into four groups according to RHR as follows: C1 (<= 60 bpm), C2 (60-70 bpm), C3 (70-80 bpm), and C4 (>= 80 bpm). Individuals with higher RHR exhibited poorer metabolic and inflammatory profiles, with the prevalence of low NKA being highest in the highest RHR category. Compared with C1 as reference, the fully adjusted odd ratios (ORs) [95% confidence intervals (CIs)] for low NKA were significantly higher in C3 (OR: 1.37, 95% CI: 1.08-1.75) and C4 (OR: 1.55, 95% CI: 1.20-2.00). In addition, RHR was shown to exert indirect effects on NKA upon consideration of the mediation effect of serum cortisol in path analysis. Our findings confirm a significant link between elevated RHR and low NKA, and suggest the usefulness of RHR, a simple indicator reflecting increased sympathetic nervous system activity and stress, in predicting reduced immune function.
C1 [Oh, Hyoju; Jeon, Joo-Hwan; Suh, Eunkyung; Lee, Yun-Kyong] CHA Univ, Chaum Life Ctr, Seoul, South Korea.
   [Cho, A-Ra] Yonsei Univ, Coll Med, Dept Family Med, Seoul, South Korea.
   [Moon, Junhyung; Cho, Baek Hwan] CHA Univ, CHA Univ Sch Med, Dept Biomed Informat, Seongnam, South Korea.
C3 Pochon Cha University; Yonsei University; Yonsei University Health
   System; Pochon Cha University
RP Lee, YK (corresponding author), CHA Univ, Chaum Life Ctr, Seoul, South Korea.; Cho, BH (corresponding author), CHA Univ, CHA Univ Sch Med, Dept Biomed Informat, Seongnam, South Korea.
EM baekhwan.cho@cha.ac.kr; ykleefm@cha.ac.kr
RI Cho, Baek Hwan/ABC-8231-2021
FU Institute of Information & Communications Technology Planning &
   Evaluation (IITP) grant - Korea government(MSIT) [RS-2024-00357879];
   NKMAX Co., Ltd. [2021-09-047]
FX The author(s) declare financial support was received for the research,
   authorship, and/or publication of this article. This research was
   supported by the Institute of Information & Communications Technology
   Planning & Evaluation (IITP) grant funded by the Korea government(MSIT)
   (No. RS-2024-00357879, AI-based Biosignal Fusion and Generation
   Technology for Intelligent Personalized Chronic Disease Management) and
   NKMAX Co., Ltd. (grant number 2021-09-047). The funder was not involved
   in the study design, collection, analysis, interpretation of data, the
   writing of this article or the decision to submit it for publication.
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NR 48
TC 0
Z9 0
U1 1
U2 1
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-3224
J9 FRONT IMMUNOL
JI Front. Immunol.
PD SEP 27
PY 2024
VL 15
AR 1465953
DI 10.3389/fimmu.2024.1465953
PG 8
WC Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology
GA J4F7R
UT WOS:001336645100001
PM 39399484
OA gold
DA 2025-06-11
ER

PT J
AU Du, M
   Deng, K
   Cai, QQ
   Hu, SX
   Chen, YT
   Xu, SL
   Tjakkes, GHE
   Ge, SH
   Ge, MH
   Li, A
AF Du, Mi
   Deng, Ke
   Cai, Qingqing
   Hu, Shixian
   Chen, Yuntao
   Xu, Shulan
   Tjakkes, Geerten-Has E.
   Ge, Shaohua
   Ge, Minghua
   Li, An
TI Mediating role of systemic inflammation in the association between heavy
   metals exposure and periodontitis risk
SO JOURNAL OF PERIODONTOLOGY
LA English
DT Article
DE environmental pollution; epidemiology; inflammation; periodontitis; risk
   factors
ID WHITE BLOOD-CELL; NATIONAL-HEALTH; OXIDATIVE STRESS; METABOLIC SYNDROME;
   UNITED-STATES; NUTRITION; LEAD; POPULATION; DISEASES; CADMIUM
AB BackgroundThis study evaluated the mediating role of systemic inflammation in the association between exposure to heavy metals and periodontitis in a nationwide sample of adults.MethodsPooled cross-sectional data from the National Health and Nutrition Examination Survey (NHANES 2009-2014) were used (n = 8993). Periodontitis was defined by a full-mouth examination and classified as no/mild and moderate/severe (mod/sev) groups. Blood and urinary heavy metal levels were investigated, including cadmium (Cd), lead (Pb), and mercury (Hg). In addition, systemic inflammation was assessed using circulatory leukocyte counts and C-reactive protein (CRP) levels.ResultsMultivariable logistic regression analysis revealed the positive associations of blood and urinary levels of Cd and Pb with mod/sev periodontitis. In contrast,blood Hg levels did not show a significant association. The odds of having periodontitis were 1.233 and 1.311 times higher for each one-unit increment in Ln-transformed blood Cd (95% confidence interval [CI]: 1.109-1.371) and Pb (95% CI: 1.170-1.470), respectively. Mediation analysis suggested a 6.3% to 11.5% contribution of leucocyte counts in the association of blood Cd and Pb levels with periodontitis. Sensitivity analyses for urinary Cd levels yielded consistent mediating effects. However, no significant mediating effect of CRP was detected.ConclusionHigher exposures to Cd and Pb were positively associated with periodontitis risk. These associations might be partially mediated by the elevated levels of leukocytes rather than CRP. Further longitudinal studies are needed to elucidate the discordant results of the systemic inflammatory biomarkers.
C1 [Du, Mi; Ge, Minghua] Hangzhou Med Coll, Zhejiang Prov Peoples Hosp, Otolaryngol & Head & Neck Ctr, Peoples Hosp,Dept Head & Neck Surg, Hangzhou, Peoples R China.
   [Du, Mi; Ge, Minghua] Key Lab Endocrine Gland Dis Zhejiang Prov, Hangzhou, Peoples R China.
   [Du, Mi; Ge, Minghua] Clin Res Ctr Canc Zhejiang Prov, Hangzhou, Peoples R China.
   [Du, Mi; Ge, Shaohua] Shandong Univ, Sch & Hosp Stomatol, Cheeloo Coll Med, Jinan, Peoples R China.
   [Du, Mi; Ge, Shaohua] Shandong Prov Clin Res Ctr Oral Dis, Jinan, Peoples R China.
   [Deng, Ke] Univ Hong Kong, Fac Dent, Div Periodontol & Implant Dent, Hong Kong, Peoples R China.
   [Cai, Qingqing] Southern Med Univ, Guangdong Prov Inst Nephrol, Natl Clin Res Ctr Kidney Dis, Nanfang Hosp,State Key Lab Organ Failure Res, Guangzhou, Peoples R China.
   [Hu, Shixian] Sun Yat Sen Univ, Affiliated Hosp 1, Inst Precis Med, Guangzhou, Peoples R China.
   [Hu, Shixian] Univ Groningen, Univ Med Ctr Groningen UMCG, Dept Gastroenterol & Hepatol, Groningen, Netherlands.
   [Chen, Yuntao] UCL, Dept Epidemiol & Publ Hlth, London, England.
   [Xu, Shulan] Southern Med Univ, Stomatol Hosp, Ctr Oral Implantol, Sch Stomatol, Guangzhou, Peoples R China.
   [Tjakkes, Geerten-Has E.] Univ Groningen, UMCG, Ctr Dent & Oral Hyg, Dept Periodontol, Groningen, Netherlands.
   [Li, An] Southern Med Univ, Stomatol Hosp, Sch Stomatol, Dept Periodontol, Guangzhou, Peoples R China.
C3 Hangzhou Medical College; Zhejiang Provincial People's Hospital;
   Shandong University; University of Hong Kong; Southern Medical
   University - China; Sun Yat Sen University; University of Groningen;
   University of London; University College London; Southern Medical
   University - China; University of Groningen; Southern Medical University
   - China
RP Li, A (corresponding author), Southern Med Univ, Stomatol Hosp, Sch Stomatol, Dept Periodontol, Guangzhou, Peoples R China.
EM ali9714ew@smu.edu.cn
RI Xu, shulan/GZM-8844-2022; Cai, Qingqing/ADM-8498-2022; Du,
   Mi/AFT-2371-2022; Hu, Shixian/CAG-6530-2022; Li, An/AAW-8494-2021
OI Du, Mi/0000-0002-2237-9918; Li, An/0000-0001-5750-526X; Chen,
   Simon/0000-0002-2536-3524
FU The authors acknowledge the support by the Major Innovation Projects in
   Shandong Province (No. 2021SFGC0502) [Jinan, China], the China
   Postdoctoral Science Foundation (No. 2023M733162) [China], the Natural
   Science Foundation of Shandong Province (No. ZR202 [2021SFGC0502]; Major
   Innovation Projects in Shandong Province [2023M733162]; China
   Postdoctoral Science Foundation [ZR2022QH278]; Natural Science
   Foundation of Shandong Province; Jinan, China [SDDX202301]; Open
   Foundation of Shandong Key Laboratory of Oral Tissue Regeneration
   [2022A1515110379]; Guangdong Basic and Applied Basic Research Foundation
FX The authors thank the NHANES staff and investigators. Thanks to people
   involved in the NHANES study for making this research possible through
   their participation.r The authors acknowledge the support by the Major
   Innovation Projects in Shandong Province (No. 2021SFGC0502) [Jinan,
   China], the China Postdoctoral Science Foundation (No. 2023M733162)
   [China], the Natural Science Foundation of Shandong Province (No.
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NR 51
TC 2
Z9 2
U1 3
U2 26
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-3492
EI 1943-3670
J9 J PERIODONTOL
JI J. Periodont.
PD MAY
PY 2024
VL 95
IS 5
BP 502
EP 514
DI 10.1002/JPER.23-0079
EA NOV 2023
PG 13
WC Dentistry, Oral Surgery & Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dentistry, Oral Surgery & Medicine
GA RH0O7
UT WOS:001104868700001
PM 37986691
OA Green Published
DA 2025-06-11
ER

PT J
AU Habibi, J
   Homan, C
   Naz, H
   Chen, DQ
   Lastra, G
   Whaley-Connell, A
   Sowers, JR
   Jia, GH
AF Habibi, Javad
   Homan, Carlton
   Naz, Huma
   Chen, Dongqing
   Lastra, Guido
   Whaley-Connell, Adam
   Sowers, James R.
   Jia, Guanghong
TI Endothelial MRs Mediate Western Diet-Induced Lipid Disorders and
   Skeletal Muscle Insulin Resistance in Females
SO ENDOCRINOLOGY
LA English
DT Article
DE obesity; endothelial cells; skeletal muscle; insulin resistance;
   mineralocorticoid receptor; exosome
ID METABOLIC SYNDROME; CELLS; HEART; ALDOSTERONE; EXPRESSION; MODELS; MICE
AB Consumption of a Western diet (WD) consisting of excess fat and carbohydrates activates the renin-angiotensin-aldosterone system, which has emerged as an important risk factor for systemic and tissue insulin resistance. We recently discovered that activated mineralocorticoid receptors (MRs) in diet-induced obesity induce CD36 expression, increase ectopic lipid accumulation, and result in systemic and tissue insulin resistance. Here, we have further investigated whether endothelial cell (EC)-specific MR (ECMR) activation participates in WD-induced ectopic skeletal muscle lipid accumulation, insulin resistance, and dysfunction. Six-week-old female ECMR knockout (ECMR-/-) and wild-type (ECMR+/+) mice were fed either a WD or a chow diet for 16 weeks. ECMR-/- mice were found to have decreased WD-induced in vivo glucose intolerance and insulin resistance at 16 weeks. Improved insulin sensitivity was accompanied by increased glucose transporter type 4 expression in conjunction with improved soleus insulin metabolic signaling in phosphoinositide 3-kinases/protein kinase B and endothelial nitric oxide synthase activation. Additionally, ECMR-/- also blunted WD-induced increases in CD36 expression and associated elevations in soleus free fatty acid, total intramyocellular lipid content, oxidative stress, and soleus fibrosis. Moreover, in vitro and in vivo activation of ECMR increased EC-derived exosomal CD36 that was further taken up by skeletal muscle cells, leading to increased skeletal muscle CD36 levels. These findings indicate that in the context of an obesogenic WD, enhanced ECMR signaling increases EC-derived exosomal CD36 resulting in increased uptake and elevated concentrations of CD36 in skeletal muscle cells, contributing to increased lipid metabolic disorders and soleus insulin resistance.
C1 [Habibi, Javad; Homan, Carlton; Naz, Huma; Chen, Dongqing; Lastra, Guido; Whaley-Connell, Adam; Sowers, James R.; Jia, Guanghong] Univ Missouri, Dept Med Endocrinol & Metab, Sch Med, Columbia, MO 65212 USA.
   [Habibi, Javad; Naz, Huma; Chen, Dongqing; Lastra, Guido; Whaley-Connell, Adam; Sowers, James R.; Jia, Guanghong] Harry S Truman Mem Vet Hosp, Res Serv, Res Serv, 800 Hosp Dr, Columbia, MO 65201 USA.
   [Whaley-Connell, Adam; Sowers, James R.] Univ Missouri, Dept Med Nephrol & Hypertens, Sch Med, Columbia, MO 65212 USA.
   [Sowers, James R.; Jia, Guanghong] Univ Missouri, Dalton Cardiovasc Res Ctr, Columbia, MO 65212 USA.
   [Sowers, James R.] Univ Missouri, Dept Med Pharmacol & Physiol, Sch Med, Columbia, MO 65212 USA.
   [Jia, Guanghong] Univ Missouri, Sch Med, Dept Med Endocrinol, D109 Diabet Ctr HSC,One Hosp Dr, Columbia, MO 65212 USA.
C3 University of Missouri System; University of Missouri Columbia; US
   Department of Veterans Affairs; Veterans Health Administration (VHA);
   Harry S. Truman Memorial Veterans' Hospital; University of Missouri
   System; University of Missouri Columbia; University of Missouri System;
   University of Missouri Columbia; University of Missouri System;
   University of Missouri Columbia; University of Missouri System;
   University of Missouri Columbia
RP Jia, GH (corresponding author), Univ Missouri, Sch Med, Dept Med Endocrinol, D109 Diabet Ctr HSC,One Hosp Dr, Columbia, MO 65212 USA.
EM Jiag@health.missouri.edu
RI naz, huma/HGA-4519-2022
OI Jia, Guanghong/0000-0003-0018-5925
FU National Institute of Diabetes and Digestive and Kidney Diseases [R01
   DK124329]; American Diabetes Association Innovative Basic Science Award
   [1-17-IBS-201]; NIH [R01 HL73101-01A, R01 HL107910-01]; Veterans Affairs
   Merit System [BX003391, 5101BX001981]
FX This research was supported by the National Institute of Diabetes and
   Digestive and Kidney Diseases (R01 DK124329) and an American Diabetes
   Association Innovative Basic Science Award (1-17-IBS-201) to G. Jia. Dr.
   Sowers received funding from NIH (R01 HL73101-01A and R01 HL107910-01).
   Drs. Whaley-Connell and Lastra received funding from Veterans Affairs
   Merit System Grants BX003391 and 5101BX001981, respectively.
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NR 54
TC 7
Z9 7
U1 0
U2 3
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0013-7227
EI 1945-7170
J9 ENDOCRINOLOGY
JI Endocrinology
PD JUN 6
PY 2023
VL 164
IS 7
AR bqad091
DI 10.1210/endocr/bqad091
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA K4RY4
UT WOS:001016338400002
PM 37289042
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Kwon, JA
   Kim, B
   Kim, E
   Kwon, K
AF Kwon, Jeoung A.
   Kim, Byungmi
   Kim, Eunji
   Kwon, Kisung
TI Interaction between blood cadmium and lead concentration and physical
   activity on hypertension from the Korean national health and nutrition
   examination survey in 2008-2013
SO BMC PUBLIC HEALTH
LA English
DT Article
DE Physical activity; Cadmium; Lead; Blood pressure; Hypertension;
   Interaction
ID ENDOTHELIAL FUNCTION; OXIDATIVE STRESS; INFLAMMATORY MARKERS; METABOLIC
   SYNDROME; NITRIC-OXIDE; ODDS RATIOS; EXERCISE; EXPOSURE; MERCURY;
   ASSOCIATION
AB BackgroundPrevious studies have suggested that blood Cd, Pb exposure, and physical activity levels may influence the development of hypertension. This study aimed to investigate the relationship between blood Cd, Pb levels, and hypertension by the level of physical activity in Korean adults using The Korea National Health and Nutrition Examination Survey (KNHANES).MethodsWe used data from the KNHANES (2008-2013), a nationally representative, cross-sectional, population-based study. We included 8,510 participants who had records of blood Cd, Pb and, blood pressure measurements. Multiple logistic regression was used to examine the association between blood Cd and Pb exposure and the development of hypertension, as well as the modifying effects of physical activity levels. Additive interaction was estimated using relative excess risk due to interaction (RERI), attributable proportion due to interaction (AP) and synergy index (S).ResultsFollowing covariates adjustments, we found significant associations of blood Cd and Pb with higher hypertension prevalence. This association was more apparent in low physical activity while blood Cd and Pb concentrations were not significantly associated with hypertension in participants with more activity. Additionally, there was a significant interaction between blood Cd and physical activity on hypertension risk (RERI = 0.17, 95% CI: -0.36-0.7; AP = 0.12, 95% CI: -0.28-0.52; S = 1.75, 95% CI:1.36-2.14).ConclusionsOur results suggest that low physical activity may substantially amplify the adverse effects of blood Pb and Cd exposure on hypertension risk. However, interactions were only found for Cd. Further studies are needed to confirm these findings.
C1 [Kwon, Jeoung A.] Yonsei Univ, Inst Hlth Serv Res, Seoul, South Korea.
   [Kwon, Jeoung A.; Kim, Byungmi] Natl Canc Ctr, Natl Canc Control Inst, Goyang, South Korea.
   [Kim, Byungmi] Natl Canc Ctr, Grad Sch Canc Sci & Policy, Goyang, South Korea.
   [Kim, Eunji] Ewha Womans Univ, Coll Med, Dept Environm Med, Seoul, South Korea.
   [Kwon, Kisung] Kangwon Natl Univ, Coll Art Cultural & Engn, Dept Sport Sci, Chunchon, South Korea.
C3 Yonsei University; National Cancer Center - Korea (NCC); National Cancer
   Center - Korea (NCC); Ewha Womans University; Kangwon National
   University
RP Kwon, K (corresponding author), Kangwon Natl Univ, Coll Art Cultural & Engn, Dept Sport Sci, Chunchon, South Korea.
EM k.kwon@kangwon.ac.kr
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NR 59
TC 6
Z9 6
U1 1
U2 5
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2458
J9 BMC PUBLIC HEALTH
JI BMC Public Health
PD APR 17
PY 2023
VL 23
IS 1
AR 703
DI 10.1186/s12889-023-15614-x
PG 11
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA D5XP3
UT WOS:000969463200002
PM 37069558
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Mohammadrezaei, A
   Ardekani, AM
   Abbasalizad-Farhangi, M
   Mesgari-Abbasi, M
   Mousavi, R
AF Mohammadrezaei, Ali
   Ardekani, Abnoos Mokhtari
   Abbasalizad-Farhangi, Mahdieh
   Mesgari-Abbasi, Mehran
   Mousavi, Reihaneh
TI Association Between Sex Hormone-Binding Globulin, Atherogenic Indices of
   Plasma Among Young Sedentary Males
SO NUTRITION AND METABOLIC INSIGHTS
LA English
DT Article
DE Sex hormone-binding globulin; SHBG; testosterone; lipid profile;
   cardiovascular risk factors; CVD; atherogenic index; oxidative stress
ID CARDIOVASCULAR RISK-FACTORS; C-REACTIVE PROTEIN; DEPENDENT
   DIABETES-MELLITUS; LOW SERUM TESTOSTERONE; INSULIN SENSITIVITY; LIPID
   PROFILE; METABOLIC SYNDROME; MEN; ANDROGENS; DISEASE
AB Background:Males are more likely than females to suffer from cardiovascular disease (CVD). So, sex hormones may modify these variations and affect the lipid profile. We examined the relationship between sex hormone-binding globulin (SHBG) and CVD risk factors among young males in this study. Methods:Using a cross-sectional design, we measured total testosterone, SHBG, lipids, glucose, insulin, antioxidant parameters, and anthropometric factors in 48 young males in the age range of 18 to 40 years. Atherogenic indices of plasma were calculated. In this study, a partial correlation analysis was carried out to assess the relationship between SHBG and other variables after adjustment for confounders. Results:According to the results of multivariable analyses adjusted for age and energy, SHBG had a negative correlation with total cholesterol (r = -.454, P =.010), low-density lipoprotein cholesterol (r = -.496, P =.005), quantitative insulin-sensitivity check index, and positive correlation with high-density lipoprotein cholesterol (r = .463, P =.009). No significant correlation was observed between SHBG and triglycerides (P >.05). Several atherogenic indices of plasma have a negative correlation with SHBG levels. These include Atherogenic Index of Plasma (r = -.474, P = .006), Castelli Risk Index (CRI)1 (r = -.581, P < .001), CRI2 (r = -.564, P = .001), and Atherogenic Coefficient (r = -.581, P < .001). Conclusion:Among young men, high plasma SHBG was associated with reduced CVD risk factors, modified lipid profile and atherogenic ratios, and better glycemic markers. Therefore, reduced SHBG concentrations could be a prognostic marker of CVD among young sedentary males.
C1 [Mohammadrezaei, Ali] Tabriz Univ Med Sci, Mol Med Res Ctr, Tabriz, Iran.
   [Ardekani, Abnoos Mokhtari] Kerman Univ Med Sci, Inst Basic & Clin Physiol Sci, Endocrinol & Metab Res Ctr, Kerman, Iran.
   [Ardekani, Abnoos Mokhtari] Kerman Univ Med Sci, Physiol Res Ctr, Kerman, Iran.
   [Abbasalizad-Farhangi, Mahdieh] Tabriz Univ Med Sci, Fac Nutr, Dept Commun Nutr, Tabriz, Iran.
   [Mesgari-Abbasi, Mehran] Tabriz Univ Med Sci, Drug Appl Res Ctr, Tabriz, Iran.
   [Mousavi, Reihaneh] Iranian Social Secur Org, Bahman Hosp 29, Tabriz, Iran.
   [Abbasalizad-Farhangi, Mahdieh] Tabriz Univ Med Sci, Attar Neyshabouri St,Bolvar Daneshgah Ave, Tabriz 516615731, Iran.
C3 Tabriz University of Medical Science; Kerman University of Medical
   Sciences; Kerman University of Medical Sciences; Tabriz University of
   Medical Science; Tabriz University of Medical Science; Tabriz University
   of Medical Science
RP Abbasalizad-Farhangi, M (corresponding author), Tabriz Univ Med Sci, Attar Neyshabouri St,Bolvar Daneshgah Ave, Tabriz 516615731, Iran.
EM abbasalizad_m@yahoo.com
RI Abbasi, Mehran/D-3557-2017; Mokhtari, Abnoos/GYV-5829-2022; Farhangi,
   Mahdieh/AAC-6758-2019
FU Tabriz University of Medical Sciences [IR.TBZMED.REC.1399.1015]
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: The
   current work has been granted by Tabriz University of Medical Sciences
   (Code:IR.TBZMED.REC.1399.1015).
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NR 92
TC 2
Z9 2
U1 2
U2 6
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1178-6388
J9 NUTR METAB INSIGHTS
JI Nutr. Metab. Insights
PY 2023
VL 16
AR 11786388231155006
DI 10.1177/11786388231155006
PG 8
WC Nutrition & Dietetics
WE Emerging Sources Citation Index (ESCI)
SC Nutrition & Dietetics
GA 9G1II
UT WOS:000937913400001
PM 36860914
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Ding, XY
   Bian, NN
   Wang, JX
   Chang, XN
   An, Y
   Wang, G
   Liu, J
AF Ding, Xiaoyu
   Bian, Nannan
   Wang, Jiaxuan
   Chang, Xiaona
   An, Yu
   Wang, Guang
   Liu, Jia
TI Serum Ferritin Levels Are Associated with Adipose Tissue
   Dysfunction-Related Indices in Obese Adults
SO BIOLOGICAL TRACE ELEMENT RESEARCH
LA English
DT Article
DE Obesity; Serum ferritin; Iron metabolism; Adipose tissue dysfunction
ID FATTY-ACID-METABOLISM; INSULIN-RESISTANCE; IRON STATUS; GLUCOSE;
   ADIPONECTIN; TRANSFERRIN; MORTALITY; STRESS; GUT
AB Iron overload is associated with type 2 diabetes and metabolic syndrome. However, little is known about the role of iron status on adipose tissue. We aimed to investigate the association of iron metabolism markers with adipose tissue dysfunction-related indices in obese individuals. A total of 226 obese adults with body mass index (BMI) >= 30 kg/m(2) were recruited into the study. Hemoglobin, serum ferritin, iron, soluble transferrin receptor (sTfR), total iron-binding capacity (TIBC), transferrin saturation (TSAT), and other clinical parameters were measured. Adipose tissue dysfunction was assessed by adipose tissue insulin resistance (adipose-IR), visceral adiposity index (VAI), and lipid accumulation product (LAP) index. Serum ferritin levels, adipose-IR, and VAI progressively increased from class I to class III obesity and significantly higher in class III obesity. Correlation analysis suggested that only serum ferritin levels were positively correlated with adipose-IR (r = 0.284, P < 0.001), VAI (r = 0.209, P = 0.002), and LAP (r = 0.324, P < 0.001). Moreover, further logistic regression analysis revealed serum ferritin was significantly associated with elevated adipose-IR, VAI, and LAP. After adjustment for potential confounders, serum ferritin levels remained independently associated with elevated adipose-IR (OR = 1.004, 95% CI 1.000-1.009, P < 0.05) and VAI (OR =1.005, 95% CI 1.001-1.009, P < 0.05). Serum ferritin was associated with elevated adipose-IR, VAI, and LAP, suggesting that ferritin could be an important early indicator for the risk of developing adipose tissue dysfunction in obese individuals.
C1 [Ding, Xiaoyu; Bian, Nannan; Wang, Jiaxuan; Chang, Xiaona; An, Yu; Wang, Guang; Liu, Jia] Capital Med Univ, Beijing Chao Yang Hosp, Dept Endocrinol, 8 Gongti South Rd, Beijing 100020, Peoples R China.
C3 Capital Medical University
RP Wang, G; Liu, J (corresponding author), Capital Med Univ, Beijing Chao Yang Hosp, Dept Endocrinol, 8 Gongti South Rd, Beijing 100020, Peoples R China.
EM drwg6688@126.com; liujia0116@126.com
RI WANG, JIAXUAN/JMP-8599-2023
OI wang, guang/0000-0001-9321-5200
FU Beijing Natural Science Foundation [Z200019]
FX This work was supported by grants from Beijing Natural Science
   Foundation (Z200019) to Jia Liu.
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NR 38
TC 4
Z9 4
U1 0
U2 4
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0163-4984
EI 1559-0720
J9 BIOL TRACE ELEM RES
JI Biol. Trace Elem. Res.
PD FEB
PY 2023
VL 201
IS 2
BP 636
EP 643
DI 10.1007/s12011-022-03198-3
EA MAR 2022
PG 8
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 8H8CN
UT WOS:000769885600001
PM 35297006
DA 2025-06-11
ER

PT J
AU Campani, C
   Nault, JC
AF Campani, Claudia
   Nault, Jean-Charles
TI Molecular mechanisms of liver carcinogenesis related to metabolic
   syndrome
SO HEPATOMA RESEARCH
LA English
DT Review
DE Hepatocellular carcinoma; mouse model; genetic predisposition;
   cirrhosis; non-alcoholic fatty liver disease; immune system
ID GENOME-WIDE ASSOCIATION; FATTY LIVER; HEPATOCELLULAR-CARCINOMA;
   NONALCOHOLIC STEATOHEPATITIS; MURINE MODEL; CONFERS SUSCEPTIBILITY;
   HISTOLOGICAL SEVERITY; INCREASED RISK; ANIMAL-MODEL; PNPLA3
AB Global prevalence of non-alcoholic fatty liver disease (NAFLD) and of NAFLD-hepatocellular carcinoma (HCC) is estimated to grow in the next years. The burden of NAFLD and the evidence that NAFLD-HCC arises also in non-cirrhotic patients, explain the urgent need of a better characterization of the molecular mechanisms involved in NAFLD progression. Obesity and diabetes cause a chronic inflammatory state which favors changes in serum cytokines and adipokines, an increase in oxidative stress, DNA damage, and the activation of multiple signaling pathways involved in cell proliferation. Moreover, a role in promoting NAFLD-HCC has been highlighted in the innate and adaptive immune system, dysbiosis, and alterations in bile acids metabolism. Several dietary, genetic, or combined mouse models have been used to study nonalcoholic steatohepatitis (NASH) development and its progression to HCC, but models that fully recapitulate the biological and prognostic features of human NASH are still lacking. In humans, four single nucleotide polymorphisms (PNPLA3, TM6SF2, GCKR, and MBOAT7) have been linked to the development of both NASH and HCC in cirrhotic and non-cirrhotic patients, whereas HSD17B13 polymorphism has a protective effect. In addition, higher rates of somatic ACVR2A mutations and a novel mutational signature have been recently discovered in NASH-HCC patients. The knowledge of the molecular pathogenesis of NAFLD-HCC will be helpful to personalized screening programs and allow for primary and secondary chemopreventive treatments for NAFLD patients who are more likely to progress to HCC.
C1 [Campani, Claudia; Nault, Jean-Charles] Univ Paris, Sorbonne Univ, Ctr Rech Cordeliers, Team Funct Genom Solid Tumors, F-75006 Paris, France.
   [Campani, Claudia; Nault, Jean-Charles] Equipe Labellisee Ligue Natl Canc, Labex OncoImmunol, F-75006 Paris, France.
   [Campani, Claudia] Univ Florence, Dept Expt & Clin Med, I-50139 Florence, Italy.
   [Nault, Jean-Charles] Hop Univ Paris Seine St Denis, Serv Hepatol, Hop Avicenne, AP HP, 125 Rue Stalingrad, F-93000 Bobigny, France.
   [Nault, Jean-Charles] Univ Paris 13, Unite Format & Rech Sante Med & Biol Humaine, Communaute Univ & Etablissements Sorbonne Paris C, F-93000 Bobigny, France.
C3 Sorbonne Universite; Universite Paris Cite; Institut National de la
   Sante et de la Recherche Medicale (Inserm); University of Florence;
   Assistance Publique Hopitaux Paris (APHP); Hopital Universitaire
   Avicenne - APHP; Universite Paris 13; Universite Paris 13
RP Nault, JC (corresponding author), Hop Univ Paris Seine St Denis, Serv Hepatol, Hop Avicenne, AP HP, 125 Rue Stalingrad, F-93000 Bobigny, France.
EM naultjc@gmail.com
RI Campani, Claudia/AAC-4021-2022
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NR 88
TC 3
Z9 3
U1 0
U2 2
PU OAE PUBLISHING INC
PI ALHAMBRA
PA 245 E MAIN ST, ST122, ALHAMBRA, CA 91801 USA
SN 2394-5079
EI 2454-2520
J9 HEPATOMA RES
JI Hepatoma Res.
PY 2022
VL 8
AR 3
DI 10.20517/2394-5079.2021.126
PG 13
WC Oncology; Gastroenterology & Hepatology
WE Emerging Sources Citation Index (ESCI)
SC Oncology; Gastroenterology & Hepatology
GA R6FE5
UT WOS:001065284600003
OA gold
DA 2025-06-11
ER

PT J
AU Pokorska-Niewiada, K
   Brodowska, A
   Szczuko, M
AF Pokorska-Niewiada, Kamila
   Brodowska, Agnieszka
   Szczuko, Malgorzata
TI The Content of Minerals in the PCOS Group and the Correlation with the
   Parameters of Metabolism
SO NUTRIENTS
LA English
DT Article
DE polycystic ovary syndrome; microelements; erythrocytes; glycemic
   markers; lipids metabolism
ID POLYCYSTIC-OVARY-SYNDROME; TRACE-ELEMENT CONCENTRATIONS; BODY IRON
   STORES; INSULIN-RESISTANCE; ZINC SUPPLEMENTATION; SERUM MAGNESIUM;
   OXIDATIVE STRESS; CALCIUM LEVELS; HORMONE-LEVELS; OBESE WOMEN
AB Polycystic ovary syndrome (PCOS) is a common disease in women of childbearing age. It is characterized by excessive androgen production, ovulation disorders, and developing metabolic syndrome. The aim of the study was to check whether selected minerals were related to the pathophysiological mechanisms of PCOS. The concentrations of minerals were determined using an inductively coupled atomic plasma-emission spectrometer (ICP-AES Jobin Yvon JY-24). Blood samples from PCOS and control women were collected, processed, and digested with a microwave system in women with PCOS with and without insulin resistance and in the control group. It was found: zinc (Zn)-10.14 +/- 2.11, 9.89 +/- 1.44 and 10.30 +/- 1.67; nickel (Ni) 0.001 +/- 0.0009, 0.001 +/- 0.0006 and 0.002 +/- 0.00001; iron (Fe) 868.0 +/- 155.8, 835.3 +/- 156.4 and 833.0 +/- 94.6; manganese (Mn) 0.017 +/- 0.006, 0.017 +/- 0.008 and 0.020 +/- 0.009; copper (Cu) 0.714 +/- 0.129, 0.713 +/- 0.114 and 0.761 +/- 0.146; magnesium (Mg) 48.4 +/- 8.3, 50.0 +/- 8.4 and 45.3 +/- 10.7; sodium (Na) 374.3 +/- 84.3, 396.3 +/- 66.6 and 367.9 +/- 88.9; potassium (K) 2541.8 +/- 330.9, 2409.6 +/- 347.1 and 2336.9 +/- 211.4 (mu g/g). Some micronutrient deficiencies may have a negative effect on the lipid profile in PCOS patients (Ni, Na). Further studies are needed to better understand dependencies.
C1 [Pokorska-Niewiada, Kamila] West Pomeranian Univ Technol Szczecin, Dept Toxicol Dairy Technol & Food Storage, PL-71459 Szczecin, Poland.
   [Brodowska, Agnieszka] Pomeranian Med Univ, Dept Gynecol Endocrinol & Gynecol Oncol, PL-71252 Szczecin, Poland.
   [Szczuko, Malgorzata] Pomeranian Med Univ, Dept Human Nutr & Metabol, PL-71460 Szczecin, Poland.
C3 West Pomeranian University of Technology; Pomeranian Medical University;
   Pomeranian Medical University
RP Pokorska-Niewiada, K (corresponding author), West Pomeranian Univ Technol Szczecin, Dept Toxicol Dairy Technol & Food Storage, PL-71459 Szczecin, Poland.; Szczuko, M (corresponding author), Pomeranian Med Univ, Dept Human Nutr & Metabol, PL-71460 Szczecin, Poland.
EM kamila.pokorska@zut.edu.pl; agnieszka.brodowska@pum.edu.pl;
   malgorzata.szczuko@pum.edu.pl
RI Agnieszka, Brodowska/B-1622-2018; Szczuko, Malgorzata/A-9501-2015
OI POKORSKA-NIEWIADA, KAMILA/0000-0002-4835-8517; Szczuko,
   Malgorzata/0000-0001-9808-0624
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NR 61
TC 22
Z9 22
U1 1
U2 15
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JUL
PY 2021
VL 13
IS 7
AR 2214
DI 10.3390/nu13072214
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA TN5IS
UT WOS:000676268600001
PM 34203167
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Emami, MR
   Jamshidi, S
   Zarezadeh, M
   Khorshidi, M
   Olang, B
   Hezaveh, ZS
   Sohouli, M
   Aryaeian, N
AF Emami, Mohammad Reza
   Jamshidi, Sanaz
   Zarezadeh, Meysam
   Khorshidi, Masoud
   Olang, Beheshteh
   Hezaveh, Zohreh Sajadi
   Sohouli, Mohammadhassan
   Aryaeian, Naheed
TI Can vitamin E supplementation affect obesity indices? A systematic
   review and meta-analysis of twenty-four randomized controlled trials
SO CLINICAL NUTRITION
LA English
DT Review
DE Vitamin E; Tocopherol; Obesity; Weight; Systematic review; Meta-analysis
ID NONALCOHOLIC FATTY LIVER; CONJUGATED LINOLEIC-ACID; OXIDATIVE STRESS;
   INSULIN SENSITIVITY; METABOLIC SYNDROME; GENE-EXPRESSION; IRANIAN
   ADULTS; BLOOD-PRESSURE; ADIPONECTIN; INFLAMMATION
AB Background: Several mechanisms have been proposed for the effect of vitamin E on weight loss. Yet various interventional studies with wide ranges of doses and durations have reported contradictory results.
   Methods: Cochrane Library, PubMed, Scopus, and Embase databases were searched up to December 2020. Meta-analysis was performed using random-effect method. Effect size was presented as weighted mean difference (WMD) and 95% confidence interval (CI). Heterogeneity was evaluated using the I-2 index. In order to identification of potential sources of heterogeneity, predefined subgroup and meta regression analyses was conducted.
   Results: A total of 24 studies with 33 data sets were included. There was no significant effect of vitamin E on weight (WMD: 0.15, 95% CI:-1.35 to 1.65, P = 0.847), body mass index (BMI) (WMD = 0.04, 95% CI:-0.29 to 0.37, P = 0.815), and waist circumference (WC) (WMD = -0.19 kg, 95% CI:-2.06 to 1.68, P = 0.842), respectively. However, subgroup analysis revealed that vitamin E supplementation in studies conducted on participants with normal BMI (18.5-24.9) had increasing impact on BMI (P = 0.047).
   Conclusion: There was no significant effect of vitamin E supplementation on weight, BMI and WC. However, vitamin E supplementation might be associated with increasing BMI in people with normal BMI (18.5-24.9). (C) 2021 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.
C1 [Emami, Mohammad Reza] Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Clin Nutr, Tehran, Iran.
   [Jamshidi, Sanaz; Khorshidi, Masoud; Aryaeian, Naheed] Iran Univ Med Sci, Sch Publ Hlth, Dept Nutr, Tehran 1449614535, Iran.
   [Zarezadeh, Meysam] Tabriz Univ Med Sci, Student Res Comm, Tabriz, Iran.
   [Zarezadeh, Meysam] Tabriz Univ Med Sci, Sch Nutr & Food Sci, Dept Clin Nutr, Nutr Res Ctr, Tabriz, Iran.
   [Khorshidi, Masoud; Olang, Beheshteh] Shahid Beheshti Univ Med Sci, Res Inst Childrens Hlth, Pediat Gastroenterol Hepatol & Nutr Res Ctr, Tehran, Iran.
   [Olang, Beheshteh] Shahid Beheshti Univ Med Sci, Sch Med, Dept Community Med, Tehran, Iran.
   [Hezaveh, Zohreh Sajadi] Shahid Beheshti Univ Med Sci, Canc Res Ctr, Tehran, Iran.
   [Sohouli, Mohammadhassan] Iran Univ Med Sci, Student Res Comm, Tehran, Iran.
C3 Tehran University of Medical Sciences; Iran University of Medical
   Sciences; Tabriz University of Medical Science; Tabriz University of
   Medical Science; Shahid Beheshti University Medical Sciences; Shahid
   Beheshti University Medical Sciences; Shahid Beheshti University Medical
   Sciences; Iran University of Medical Sciences
RP Aryaeian, N (corresponding author), Iran Univ Med Sci, Sch Publ Hlth, Dept Nutr, Tehran 1449614535, Iran.; Khorshidi, M (corresponding author), Iran Univ Med Sci, Sch Publ Hlth, Dept Nutr, Student Res Comm, Tehran, Iran.; Zarezadeh, M (corresponding author), Tabriz Univ Med Sci, Sch Nutr & Food Sci, Nutr Sci, Attar Neishaburi St,Golgasht Alley,Azadi Blvd, Tabriz, Iran.
EM zarezadehm@tbzmed.ac.ir; khorshidi.m@iums.ac.ir; aryaeian.n@iums.ac.ir
RI Olang, Beheshteh/S-8249-2019; Sajadi'Hezaveh, Zohreh/LEM-1778-2024;
   Zarezadeh, Meysam/AFJ-1712-2022; emami, Mohammad/HGU-9687-2022;
   Aryaeian, Naheed/H-3894-2018
OI Aryaeian, Naheed/0000-0001-9662-8561; Sajadi Hezaveh,
   Zohreh/0000-0002-3806-8129; Zarezadeh, Meysam/0000-0002-4268-4178
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NR 65
TC 14
Z9 14
U1 1
U2 5
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0261-5614
EI 1532-1983
J9 CLIN NUTR
JI Clin. Nutr.
PD MAY
PY 2021
VL 40
IS 5
BP 3201
EP 3209
DI 10.1016/j.clnu.2021.02.002
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA SI3DB
UT WOS:000654704700004
PM 33632535
DA 2025-06-11
ER

PT J
AU Bellenger, J
   Bellenger, S
   Bourragat, A
   Escoula, Q
   Weill, P
   Narce, M
AF Bellenger, Jerome
   Bellenger, Sandrine
   Bourragat, Amina
   Escoula, Quentin
   Weill, Pierre
   Narce, Michel
TI Intestinal microbiota mediates the beneficial effects of n-3
   polyunsaturated fatty acids during dietary obesity
SO OCL-OILSEEDS AND FATS CROPS AND LIPIDS
LA English
DT Review
DE Dietary obesity; n-3 polyunsaturated fatty acids; metabolic endotoxemia;
   microbiota; fecal transplantation; fat-1 mice
ID ENDOPLASMIC-RETICULUM STRESS; GUT MICROBIOTA; INSULIN-RESISTANCE;
   INFLAMMATION; LIPOTOXICITY; PERMEABILITY; APOPTOSIS; INVOLVEMENT;
   MECHANISMS; PROTECTS
AB Obesity, now considered as a real worldwide epidemic affecting more than 650 million people, is complex and mainly associated with excessive energy intake and changes in eating habits favoring the consumption of diets rich in saturated fat and sugar. This multifactorial pathology is linked to chronic low grade systemic inflammation. Indeed, a high fat diet (HFD) leads to intestinal microbiota dysbiosis increasing gut permeability (partly attributed to a downregulation of genes encoding tight junction proteins) leading to an increase in bacterial lipopolysaccharides (LPS) levels so-called metabolic endotoxemia. Studies have shown that n-3 polyunsaturated fatty acids (PUFAs) are involved in the prevention of obesity and insulin resistance partly through synthesis of lipid mediators. While studies suggest that n-3 PUFAs are able to modulate the gut microbiota, others show no effect of n-3 treatments on intestinal homeostasis. In the present work, we showed that when fed a hypercaloric and obsogenic diet, compared with wild-type (WT) mice, fat-1 mice (with constitutive production of n-3 PUFAs) resist to dietary obesity and associated metabolic disorders, maintain an effective gut barrier function and exhibit greater phylogenic diversity. Moreover, fecal microbiota transplantation from fat-1 to WT mice reversed body weight gain, normalized glucose tolerance and intestinal permeability in association with prevention of alteration of the colon mucus layer. We can conclude that the n-3 PUFA-mediated alterations of gut microbiota contribute to the prevention of metabolic syndrome in fat-1 mice and may represent a promising strategy to prevent metabolic disease and preserve a lean phenotype.
C1 [Bellenger, Jerome; Bellenger, Sandrine; Bourragat, Amina; Escoula, Quentin; Narce, Michel] Univ Bourgogne Franche Comte, UFR Sci Vie Terre & Environm, Lipides Nutr Canc UMR UMR1231, 6 Blvd Gabriel, F-21000 Dijon, France.
   [Bellenger, Jerome; Bellenger, Sandrine; Bourragat, Amina; Escoula, Quentin; Narce, Michel] INSERM, Lipides Nutr Canc UMR1231, F-21000 Dijon, France.
   [Bellenger, Jerome; Bellenger, Sandrine; Bourragat, Amina; Escoula, Quentin; Narce, Michel] Fdn Cooperat Sci Bourgogne Franche Comte, LipSTIC LabEx, F-21000 Dijon, France.
   [Escoula, Quentin; Weill, Pierre] Valorex, F-35210 La Messayais, Combourtille, France.
C3 Institut Agro; AgroSup Dijon; Universite Bourgogne Europe; Institut
   National de la Sante et de la Recherche Medicale (Inserm); Universite
   Bourgogne Europe; Institut Agro; AgroSup Dijon
RP Bellenger, J (corresponding author), Univ Bourgogne Franche Comte, UFR Sci Vie Terre & Environm, Lipides Nutr Canc UMR UMR1231, 6 Blvd Gabriel, F-21000 Dijon, France.; Bellenger, J (corresponding author), INSERM, Lipides Nutr Canc UMR1231, F-21000 Dijon, France.; Bellenger, J (corresponding author), Fdn Cooperat Sci Bourgogne Franche Comte, LipSTIC LabEx, F-21000 Dijon, France.
EM jerome.bellenger@u-bourgogne.fr
RI BELLENGER, Jerome/AAC-9423-2022
OI Narce, Michel/0000-0002-9986-6247
FU INSERM (National Institute of Health and Medical Research); Regional
   Council of Burgundy; European Regional Development Fund; University of
   Burgundy; Fondation de France; National Research Agency under the
   program "Investissements d'Avenir" [ANR-11-LABX-0021-01]; Valorex
   (Combourtille, France); National Association for Technological Research
   (ANRT); CIFRE
FX This work has been supported by INSERM (National Institute of Health and
   Medical Research), the Regional Council of Burgundy, the European
   Regional Development Fund, the University of Burgundy, the Fondation de
   France, and by the National Research Agency under the program
   "Investissements d'Avenir" with the reference
   ANR-11-LABX-0021-01-LipSTIC LabEx. This project was also supported by
   Valorex (Combourtille, France) and the National Association for
   Technological Research (ANRT) with CIFRE thesis funding.
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NR 43
TC 4
Z9 5
U1 2
U2 15
PU EDP SCIENCES S A
PI LES ULIS CEDEX A
PA 17, AVE DU HOGGAR, PA COURTABOEUF, BP 112, F-91944 LES ULIS CEDEX A,
   FRANCE
SN 2272-6977
EI 2257-6614
J9 OCL OILS FAT CROP LI
JI OCL Oilseed.Fats Crops Lipids
PD MAR 22
PY 2021
VL 28
AR 21
DI 10.1051/ocl/2021006
PG 7
WC Agronomy
WE Emerging Sources Citation Index (ESCI)
SC Agriculture
GA RB3FB
UT WOS:000631998900002
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Kiani, AK
   Paolacci, S
   Calogero, AE
   Cannarella, R
   Di Renzo, GC
   Gerli, S
   Della Morte, C
   Busetto, GM
   De Berardinis, E
   Del Giudice, F
   Stuppia, L
   Facchinetti, F
   Dinicola, S
   Bertelli, M
AF Kiani, A. K.
   Paolacci, S.
   Calogero, A. E.
   Cannarella, R.
   Di Renzo, G. C.
   Gerli, S.
   Della Morte, C.
   Busetto, G. M.
   De Berardinis, E.
   Del Giudice, F.
   Stuppia, L.
   Facchinetti, F.
   Dinicola, S.
   Bertelli, M.
TI From Myo-inositol to D-chiro-inositol molecular pathways
SO EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
LA English
DT Article
DE Myo-inositol; D-chiro-inositol; Epimerase; Polymorphisms; Neural tube
   defects
ID NEURAL-TUBE DEFECTS; CDNA CLONING; 1,3,4-TRISPHOSPHATE 5/6-KINASE;
   GENOMIC ORGANIZATION; COMMON VARIANTS; GENE-EXPRESSION; RECEPTOR;
   MONOPHOSPHATASE; IDENTIFICATION; KIDNEY
AB OBJECTIVE: Inositol is a carbocyclic sugar polyalcohol. By epimerization of its hydroxyl groups, nine possible stereoisomers can be generated, two of major physiological and clinical relevance: myo-inositol and D-chiro-inositol. Myo-inositol and D-chiro-inositol are normally stored in kidney, brain and liver and are necessary for functions, such as signal transduction, metabolic flux, insulin signaling, regulation of ion-channel permeability, stress response and embryo development. In this narrative review, we summarize the mechanisms by which myo-inositol and D-chiro-inositol can be synthesized and absorbed and their possible role in the etiopathogenesis of neural tube defects.
   MATERIALS AND METHODS: We performed an online search in the PubMed database using the following keywords: "inositol", "D-chiro-inositol", "myo-inositol", "neural tube defects and inositol".
   RESULTS: Inositol requirements are partly met by dietary intake, while the rest is synthesized endogenously. Inositol deficiency may be involved in the pathogenesis of diseases, such as metabolic syndrome, spina bifida (a neural tube defect), polycystic ovary syndrome and diabetes. Supplementation of the two inositol ste-reoisomers, D-chiro-inositol and myo-inositol is important to prevent these conditions.
   CONCLUSIONS: Inositol is fundamental for signal transduction in the brain, kidneys, reproductive organs and other tissues in response to neurotransmitters, hormones and growth factors. Various genes are involved in inositol metabolism and associated pathways. Altered inositol concentrations are observed in several diseases. Analysis of the genes involved in inositol metabolism may provide important information for the clinical management of these conditions.
C1 [Kiani, A. K.; Bertelli, M.] MAGI Euregio, Bolzano, Italy.
   [Paolacci, S.; Bertelli, M.] MAGIs Lab, Rovereto, TN, Italy.
   [Calogero, A. E.; Cannarella, R.] Univ Catania, Dept Clin & Expt Med, Catania, Italy.
   [Di Renzo, G. C.] Univ Perugia, Dept Obstet & Gynaecol, Perugia, Italy.
   [Di Renzo, G. C.] Univ Perugia, Ctr Perinatal & Reprod Med, Perugia, Italy.
   [Di Renzo, G. C.] IM Sechenov First State Univ Moscow, Dept Obstet & Gynecol, Moscow, Russia.
   [Gerli, S.; Della Morte, C.] Univ Perugia, Dept Surg & Biomed Sci, S Maria Misericordia Hosp, St Andrea Delle Fratte, PG, Italy.
   [Busetto, G. M.; De Berardinis, E.; Del Giudice, F.] Sapienza Univ Rome, Dept Urol, Rome, Italy.
   [Stuppia, L.] Univ G dAnnunzio, Dept Psychol Hlth & Terr Sci, Sch Med & Hlth Sci, Chieti, Italy.
   [Facchinetti, F.] Univ Modena & Reggio Emilia, Univ Polyclin Modena, Dept Med & Surg Sci Mothers Children & Adults, Modena, Italy.
   [Dinicola, S.] Sapienza Univ Rome, Dept Expt Med, Rome, Italy.
   [Bertelli, M.] EBTNA LAB, Rovereto, TN, Italy.
C3 University of Catania; University of Perugia; University of Perugia;
   University of Perugia; Sapienza University Rome; G d'Annunzio University
   of Chieti-Pescara; Universita di Modena e Reggio Emilia; Sapienza
   University Rome
RP Paolacci, S (corresponding author), MAGIs Lab, Rovereto, TN, Italy.
EM stefano.paolacci@assomagi.org
RI Calogero, Aldo/AAA-9538-2021; Cannarella, Rossella/AAB-6486-2021; GERLI,
   SANDRO/AAJ-1067-2020; Facchinetti, Fabio/K-9929-2014; Busetto, Gian
   Maria/I-5283-2019
OI Busetto, Gian Maria/0000-0002-7291-0316; GERLI, Sandro
   Francesco/0000-0003-1082-3062
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NR 81
TC 40
Z9 45
U1 6
U2 61
PU VERDUCI PUBLISHER
PI ROME
PA VIA GREGORIO VII, ROME, 186-00165, ITALY
SN 1128-3602
J9 EUR REV MED PHARMACO
JI Eur. Rev. Med. Pharmacol. Sci.
PY 2021
VL 25
IS 5
BP 2390
EP 2402
DI 10.26355/eurrev_202103_25279
PG 13
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA QV3WY
UT WOS:000627906600036
PM 33755975
DA 2025-06-11
ER

PT J
AU Rodrigues, JAL
   Philbois, SV
   Facioli, TD
   Gastaldi, AC
   de Souza, HCD
AF Rodrigues, Jhennyfer Aline Lima
   Philbois, Stella Vieira
   de Paula Facioli, Tabata
   Gastaldi, Ada Clarice
   de Souza, Hugo Celso Dutra
TI Should Heartbeats/Training Session Be Considered When Comparing the
   Cardiovascular Benefits of High-Intensity Interval Aerobic and
   Moderate-Intensity Continuous Training? A Critical Appraisal
SO SPORTS MEDICINE-OPEN
LA English
DT Article
DE Cardiovascular disease; Physical training; Heartbeat amplitude; Shear
   stress; Cardiorespiratory fitness
ID HEART-RATE-VARIABILITY; METABOLIC SYNDROME; EXERCISE; FAILURE; DISEASE;
   MEN
AB The prescription of physical training as a therapeutic measure in the treatment and control of chronic degenerative diseases, mainly cardiovascular disease and metabolic disease, is an increasingly used clinical approach, often preceding the pharmacological prescription. Despite the advances in exercise physiology and cardio functional performance in recent decades, the main challenge is to identify the most appropriate modality, intensity, and training volume for each pathophysiological situation. In this case, the superiority of high-intensity interval training (HIIT) over moderate-intensity continuous training (MICT) has been questioned, since many studies have shown similar results in the different physiological parameters evaluated, especially regarding cardiorespiratory fitness, cardiovascular autonomic control, and cardiac morpho functionality. The cause of conflicting results observed by different studies may be related to standardization, application, and comparison of the two protocols. HIIT would have a higher number of heartbeats compared to MICT, when maintaining high heart rate is disregarded. In this since, our hypothesis for the greatest gains in cardiorespiratory fitness and in the autonomic and cardiovascular adaptations promoted by HIIT is based on the higher volume of training performed as a function of the higher number of heartbeats per unit of time, since the intermittence was calculated based on a percentage of maximum heart rate or reserve heart rate. Nevertheless, the intermittency between the established heart rate percentages is not necessarily accompanied by the intermittent heart rate. Therefore, considering and matching the number of heartbeats performed per training session in both models seems to be a more appropriate way to compare the two training protocols.
C1 [Rodrigues, Jhennyfer Aline Lima; Philbois, Stella Vieira; de Paula Facioli, Tabata; Gastaldi, Ada Clarice; de Souza, Hugo Celso Dutra] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Hlth Sci, Exercise Physiol Lab, Ave Bandeirantes 3900, BR-14049900 Ribeirao Preto, SP, Brazil.
C3 Universidade de Sao Paulo
RP de Souza, HCD (corresponding author), Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Hlth Sci, Exercise Physiol Lab, Ave Bandeirantes 3900, BR-14049900 Ribeirao Preto, SP, Brazil.
EM hugocds@fmrp.usp.br
RI Facioli, Tábata/ABD-8825-2020; Gastaldi, Ada/I-4329-2013; Philbois,
   Stella/AAZ-6110-2020; Souza, Hugo/C-5818-2012; Rodrigues,
   Jhennyfer/D-2911-2019
OI Souza, Hugo/0000-0002-0009-0005; Philbois, Stella/0000-0002-8276-1035;
   Rodrigues, Jhennyfer/0000-0002-4728-1925
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NR 22
TC 2
Z9 2
U1 1
U2 8
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 2199-1170
EI 2198-9761
J9 SPORTS MED-OPEN
JI Sports Med.-Open
PD JUL 15
PY 2020
VL 6
IS 1
AR 29
DI 10.1186/s40798-020-00257-8
PG 3
WC Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Sport Sciences
GA MR0DK
UT WOS:000553264200001
PM 32671632
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Shi, TT
   Min, M
   Sun, CY
   Cheng, C
   Zhang, Y
   Liang, MM
   Rizeq, FK
   Sun, YH
AF Shi, Tingting
   Min, Min
   Sun, Chenyu
   Cheng, Ce
   Zhang, Yun
   Liang, Mingming
   Rizeq, Feras Kamel
   Sun, Yehuan
TI A meta-analysis of the association between gout, serum uric acid level,
   and obstructive sleep apnea
SO SLEEP AND BREATHING
LA English
DT Review
DE Obstructive sleep apnea syndrome; OSAS; Serumuric acid level; Gout
ID US GENERAL-POPULATION; METABOLIC SYNDROME; OXIDATIVE STRESS;
   NATIONAL-HEALTH; INCIDENT GOUT; RISK; PREVALENCE; HYPERURICEMIA;
   EPIDEMIOLOGY; MEN
AB Previous epidemiological investigations have evaluated the association between gout, serum uric acid levels, and obstructive sleep apnea syndrome (OSAS), but with inconsistent results. We conducted this meta-analysis aiming at providing clear evidence about whether OSAS patients have higher serum uric acid levels and more susceptible to gout. Relevant studies were identified via electronic databases from inception to December 17, 2018. Study selection was conducted according to predesigned eligibility criteria, and two authors independently extracted data from included studies. The hazard ratio (HR) and weighted mean difference (WMD) and their corresponding 95% confidence interval (CI) were derived using random-effects models. We conducted meta-, heterogeneity, publication bias, sensitivity, and subgroup analyses. Eighteen studies, involving a total of 157,607 individuals (32,395 with OSAS, 125,212 without OSAS) and 12,262 gout cases, were included. Results show that serum uric acid levels are elevated in patients with OSAS (WMD=52.25, 95% CI 36.16-64.33); OSAS did not reach statistical significance as a predictor of gout (but there was a trend, HR = 1.25, 95% CI 0.91-1.70) and that the association between OSAS and serum uric acid was quite robust. OSAS may be a potential risk factor for hyperuricemia and the development of gout and thus, effective OSAS therapy may present as a valuable preventive measure against gout. Still, it is vital to undertake clinical studies with better designing to corroborate these associations and shed new light on it.
C1 [Shi, Tingting; Min, Min; Zhang, Yun; Liang, Mingming; Sun, Yehuan] Anhui Med Univ, Sch Publ Hlth, Dept Epidemiol & Hlth Stat, 81 Meishan Rd, Hefei 230032, Anhui, Peoples R China.
   [Sun, Chenyu] Anhui Med Univ, Affiliated Hosp 1, Hefei 230022, Anhui, Peoples R China.
   [Cheng, Ce] Midwestern Univ, Arizona Coll Osteopath Med, 19555 N 59th Ave, Glendale, AZ 85308 USA.
   [Rizeq, Feras Kamel] Avalon Univ, Sch Med, Santa Rosaweg 122-124, Willemstad, Curacao.
   [Sun, Yehuan] Anhui Med Univ, Ctr Evidence Based Practice, 81 Meishan Rd, Hefei 230032, Anhui, Peoples R China.
C3 Anhui Medical University; Anhui Medical University; Midwestern
   University; Midwestern University - Glendale; Anhui Medical University
RP Sun, YH (corresponding author), Anhui Med Univ, Sch Publ Hlth, Dept Epidemiol & Hlth Stat, 81 Meishan Rd, Hefei 230032, Anhui, Peoples R China.; Sun, YH (corresponding author), Anhui Med Univ, Ctr Evidence Based Practice, 81 Meishan Rd, Hefei 230032, Anhui, Peoples R China.
EM shitingting199205@163.com; 419023179@qq.com; drsunchenyu@yeah.net;
   ccheng19@midwestern.edu; 1476920440@qq.com; 840541969@qq.com;
   ferisvanatari@gmail.com; yhsun_ahmu_edu@yeah.net
RI Sun, Chenyu/M-2322-2019; shi, Tingting/KHV-1989-2024; min,
   min/KEI-3624-2024
OI Sun, Yehuan/0000-0002-8651-8059; Sun, Chenyu/0000-0003-3812-3164
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U1 0
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PU SPRINGER HEIDELBERG
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PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1520-9512
EI 1522-1709
J9 SLEEP BREATH
JI Sleep Breath.
PD DEC
PY 2019
VL 23
IS 4
BP 1047
EP 1057
DI 10.1007/s11325-019-01827-1
PG 11
WC Clinical Neurology; Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Respiratory System
GA KH1JV
UT WOS:000510403600004
PM 30903565
DA 2025-06-11
ER

PT J
AU Kuwabara, M
   Chintaluru, Y
   Kanbay, M
   Niwa, K
   Hisatome, I
   Andres-Hernando, A
   Roncal-Jimenez, C
   Ohno, M
   Johnson, RJ
   Lanaspa, MA
AF Kuwabara, Masanari
   Chintaluru, Yaswanth
   Kanbay, Mehmet
   Niwa, Koichiro
   Hisatome, Ichiro
   Andres-Hernando, Ana
   Roncal-Jimenez, Carlos
   Ohno, Minoru
   Johnson, Richard J.
   Lanaspa, Miguel A.
TI Fasting blood glucose is predictive of hypertension in a generalJapanese
   population
SO JOURNAL OF HYPERTENSION
LA English
DT Article
DE epidemiology; glucose; hypertension; risk factor; uric acid
ID SERUM URIC-ACID; RISK-FACTOR; METABOLIC SYNDROME; DIABETES-MELLITUS;
   OXIDATIVE STRESS; FOLLOW-UP; HYPERURICEMIA; DISEASE; ASSOCIATION;
   PREVALENCE
AB Objective: This study was conducted to identify whether higher fasting blood glucose levels is predictive of hypertension by a large-scale longitudinal design.
   Methods: We conducted a retrospective 5-year cohort study using the data from 13 201 Japanese individuals who underwent annual medical examinations in 2004 and were reevaluated 5 years later. This study included individuals without diabetes or hypertension between ages 30 and 85 years in 2004. The cumulative incidences of hypertension over 5 years in each 10 mg/dl of fasting blood glucose levels were calculated. Moreover, we examined risk factors and calculated odds ratios (ORs) for developing hypertension after adjustments for age, sex, BMI, smoking and drinking habits, dyslipidemia, chronic kidney disease, serum uric acid, and fasting blood glucose levels by logistic regression analyses.
   Results: We analyzed 10 157 participants (age: 48.9 +/- 10.7 years; 43.4% men) without diabetes or hypertension in 2004. After multiple adjustments, higher baseline blood glucose level is an independent risk for hypertension (OR: 1.176; 95% CI 1.086-1.275), as well as aging, women, higher BMI, drinking habits, and higher serum uric acid. After stratifying by sex, higher baseline blood glucose level is an independent risk for hypertension both in women (OR: 1.295; 95% CI 1.135-1.478) and men (OR: 1.108; 95% CI 1.001-1.227). When we conducted the same analysis using glycated hemoglobin instead of blood glucose, glycated hemoglobin was not a risk for hypertension.
   Conclusion: Higher fasting blood glucose is an independent risk for developing hypertension. Further studies are needed to determine if treatment for elevated blood glucose can prevent developing hypertension.
C1 [Kuwabara, Masanari; Ohno, Minoru] Toranomon Gen Hosp, Dept Cardiol, Tokyo, Japan.
   [Kuwabara, Masanari; Chintaluru, Yaswanth; Andres-Hernando, Ana; Roncal-Jimenez, Carlos; Johnson, Richard J.; Lanaspa, Miguel A.] Univ Colorado Denver, Sch Med, Div Renal Dis & Hypertens, Aurora, CO USA.
   [Kuwabara, Masanari; Niwa, Koichiro] St Lukes Int Hosp, Cardiovasc Ctr, Tokyo, Japan.
   [Kanbay, Mehmet] Koc Univ, Sch Med, Dept Internal Med, Div Nephrol, Istanbul, Turkey.
   [Hisatome, Ichiro] Tottori Univ, Grad Sch Med Sci, Div Regenerat Med & Therapeut, Tottori, Japan.
C3 Toranomon Hospital; Children's Hospital Colorado; University of Colorado
   System; University of Colorado Anschutz Medical Campus; St. Luke's
   International Hospital; Koc University; Tottori University
RP Kuwabara, M (corresponding author), Toranomon Gen Hosp, Dept Cardiol, Minato Ku, 2-2-2 Toranomon, Tokyo 1058470, Japan.
EM kuwamasa728@gmail.com
RI 1, 1/IAO-4606-2023; Lanaspa, Miguel/AAO-4971-2020; Kuwabara,
   Masanari/O-9844-2017
OI Andres-Hernando, Ana/0000-0002-0676-0188; Kuwabara,
   Masanari/0000-0002-6601-4347
CR [Anonymous], PAK J PHARM SCI SUPP
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NR 44
TC 44
Z9 49
U1 0
U2 10
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0263-6352
EI 1473-5598
J9 J HYPERTENS
JI J. Hypertens.
PD JAN
PY 2019
VL 37
IS 1
BP 167
EP 174
DI 10.1097/HJH.0000000000001895
PG 8
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA HX4AH
UT WOS:000467336300025
PM 30507865
DA 2025-06-11
ER

PT J
AU Banini, BA
   Sanyal, AJ
AF Banini, Bubu A.
   Sanyal, Arun J.
TI Current and future pharmacologic treatment of nonalcoholic
   steatohepatitis
SO CURRENT OPINION IN GASTROENTEROLOGY
LA English
DT Review
DE chronic liver disease; cirrhosis; fibrosis; nonalcoholic fatty liver
   disease; nonalcoholic steatohepatitis
ID FATTY LIVER-DISEASE; RANDOMIZED CONTROLLED-TRIAL; GLUCAGON-LIKE
   PEPTIDE-1; VITAMIN-E; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   PROSTATE-CANCER; POOLED ANALYSIS; DOUBLE-BLIND; MOUSE MODEL
AB Purpose of review
   Nonalcoholic steatohepatitis (NASH), the aggressive form of nonalcoholic fatty liver disease (NAFLD), can progress to cirrhosis and hepatocellular cancer in 5-15% of patients and is rapidly becoming the leading cause for end-stage liver disease. Dietary caloric restriction and exercise, currently the cornerstone of therapy for NAFLD, can be difficult to achieve and maintain, underscoring the dire need for pharmacotherapy. This review presents the agents currently used in managing NAFLD and their pharmacologic targets. It also provides an overview of NAFLD agents currently under development.
   Recent findings
   Therapies for NASH can be broadly classified into agents that target the metabolic perturbations driving disease pathogenesis (such as insulin resistance and de novo lipogenesis) and agents that target downstream processes including cell stress, apoptosis, inflammation, and fibrosis. Modulation of peroxisome proliferator-activator receptors, farnesoid-X-receptors, and the glucagon-like peptide 1 pathway have been shown to improve liver histology. The intestinal microbiome and metabolic endotoxemia are novel targets that are currently under review. Antioxidants such as vitamin E, and more recently antiinflammatory agents such as apoptosis signal-regulating kinase 1 inhibitors show promise as therapy for NASH. Several antifibrotic agents including cysteine-cysteine motif chemokine receptor type 2 and type 5 antagonists have been shown to inhibit the progression of fibrosis toward cirrhosis.
   Summary
   There are currently several agents in the drug pipeline for NASH. Within the next few years, the availability of therapeutic options for NAFLD will hopefully curb the rising trend of NAFLD-related end stage liver disease.
C1 [Banini, Bubu A.; Sanyal, Arun J.] Virginia Commonwealth Univ, Dept Internal Med, Div Gastroenterol Hepatol & Nutr, Sch Med, Richmond, VA USA.
C3 Virginia Commonwealth University
RP Sanyal, AJ (corresponding author), MCV Box 980341, Richmond, VA 23298 USA.
EM arun.sanyal@vcuhealth.org
OI Banini, Bubu/0000-0002-2972-9263
FU NIDDK [T32 DK 7150-40]; Pfizer; Conatus; Novartis; Lilly; Hemoshear;
   Salix; Merck; Astra Zeneca; Bristol Myers; Shire
FX The work was supported by a training grant T32 DK 7150-40 from NIDDK to
   A.J.S.A. J. S. is the President of Sanyal Bio and has stock options in
   Genfit, NewCo LLC, Akarna, Indalo, and Exhalenz. He has been a paid
   consultant to Pfizer, Conatus, Novartis, Lilly, Hemoshear, and Salix. He
   is an unpaid consultant to Intercept, Tobira, Merck, Bristol Myers
   Squibb, Nitto Denko, Novo Nordisk, Nordic Bio-Science, Syntlogic,
   Canfite, Jannsen, Gilead, and Galectin. His institution has received
   grant support from Merck, Astra Zeneca, Bristol Myers, Novartis, Shire,
   and Conatus.
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NR 60
TC 39
Z9 46
U1 1
U2 12
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0267-1379
EI 1531-7056
J9 CURR OPIN GASTROEN
JI Curr. Opin. Gastroenterol.
PD MAY
PY 2017
VL 33
IS 3
BP 134
EP 141
DI 10.1097/MOG.0000000000000356
PG 8
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA ES3MB
UT WOS:000399432600005
PM 28346237
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Tozuka, Y
   Kumon, M
   Wada, E
   Onodera, M
   Mochizuki, H
   Wada, K
AF Tozuka, Yusuke
   Kumon, Mami
   Wada, Etsuko
   Onodera, Masafumi
   Mochizuki, Hideki
   Wada, Keiji
TI Maternal obesity impairs hippocampal BDNF production and spatial
   learning performance in young mouse offspring
SO NEUROCHEMISTRY INTERNATIONAL
LA English
DT Article
DE Lifestyle; Maternal effect; Development; Neurogenesis; Learning and
   memory
ID HIGH-FAT DIET; NEUROTROPHIC FACTOR EXPRESSION; INCREASED OXIDATIVE
   STRESS; INDUCED INSULIN-RESISTANCE; NEURAL PROGENITOR CELLS; FEMALE MICE
   LEADS; SHORT-TERM-MEMORY; SYNAPTIC PLASTICITY; NEURONAL PLASTICITY;
   COGNITIVE PERFORMANCE
AB Maternal obesity may affect the child's long-term development and health, increasing the risk of diabetes and metabolic syndrome. In addition to the metabolic and endocrine systems, recent reports have indicated that maternal obesity also modulates neural circuit formation in the offspring. However, this not yet been fully investigated. Here, we examined the effect of diet-induced maternal obesity on hippocampal development and function in the mouse offspring. Adult female mice were fed either a normal diet (ND, 4% fat) or a high-fat diet (HFD, 32% fat) before mating and throughout pregnancy and lactation. After weaning, all offspring were fed with a normal diet. We found that HFD offspring showed increased lipid peroxidation in the hippocampus during early postnatal development. HFD offspring had less brain-derived neurotrophic factor (BDNF) in the hippocampus than ND offspring. BDNF has been shown to play crucial roles in neuronal differentiation, plasticity and hippocampus-dependent cognitive functions such as spatial learning and memory. Using retroviral labeling, we demonstrated that dendritic arborization of new hippocampal neurons was impaired in the young HFD offspring. Finally, we evaluated cognitive function in these offspring using hippocampus-dependent behavioral tasks. The Barnes maze test demonstrated that HFD offspring showed impaired acquisition of spatial learning in the young but not adult period. This study, using a mouse model, indicates that diet-induced maternal obesity impairs hippocampal BDNF production and spatial cognitive function in young offspring, possibly due to their metabolic and oxidative changes. (C) 2010 Elsevier Ltd. All rights reserved.
C1 [Tozuka, Yusuke; Kumon, Mami; Wada, Etsuko; Wada, Keiji] Natl Ctr Neurol & Psychiat, Natl Inst Neurosci, Dept Degenerat Neurol Dis, Kodaira, Tokyo 1878502, Japan.
   [Tozuka, Yusuke] Japan Assoc Advancement Med Equipment, Tokyo, Japan.
   [Tozuka, Yusuke; Kumon, Mami; Wada, Etsuko; Wada, Keiji] Japan Sci & Technol Agcy, Saitama, Japan.
   [Onodera, Masafumi] Natl Res Inst Child Hlth & Dev, Dept Genet, Tokyo, Japan.
   [Mochizuki, Hideki] Kitasato Univ, Dept Neurol, Sch Med, Kanagawa, Japan.
C3 National Center for Neurology & Psychiatry - Japan; Japan Science &
   Technology Agency (JST); National Center for Child Health & Development
   - Japan; Kitasato University
RP Wada, K (corresponding author), Natl Ctr Neurol & Psychiat, Natl Inst Neurosci, Dept Degenerat Neurol Dis, 4-1-1 Ogawahigasi, Kodaira, Tokyo 1878502, Japan.
EM wada@ncnp.go.jp
RI Wada, Keiji/AAV-1500-2021
FU Ministry of Health, Labour and Welfare of Japan; National Institute of
   Biomedical Innovation; Japan Science and Technology Agency
FX We thank Masayuki Sekiguchi (NCNP), Heng Li (NCNP), Daisuke Yamada
   (NCNP), Hiromi Fujita (NCNP) and Takashi Namba (Nagoya University) for
   informative discussions and technical assistance. This work was
   supported in part by grants-in-aid for scientific research from the
   Ministry of Health, Labour and Welfare of Japan; the Program for
   Promotion of Fundamental Studies in Health Sciences of the National
   Institute of Biomedical Innovation; and a grant from the Japan Science
   and Technology Agency.
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NR 81
TC 213
Z9 237
U1 2
U2 34
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0197-0186
EI 1872-9754
J9 NEUROCHEM INT
JI Neurochem. Int.
PD OCT
PY 2010
VL 57
IS 3
BP 235
EP 247
DI 10.1016/j.neuint.2010.05.015
PG 13
WC Biochemistry & Molecular Biology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Neurosciences & Neurology
GA 638UW
UT WOS:000280923600007
PM 20538025
DA 2025-06-11
ER

PT J
AU Song, J
   Ren, PP
   Zhang, L
   Wang, XL
   Chen, L
   Shen, YH
AF Song, Jun
   Ren, Pingping
   Zhang, Lin
   Wang, Xing Li
   Chen, Li
   Shen, Ying H.
TI Metformin reduces lipid accumulation in macrophages by inhibiting
   FOXO1-mediated transcription of fatty acid-binding protein 4
SO BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
LA English
DT Article
DE Metformin; FOXO1; Fatty acid-binding protein 4; Lipid accumulation in
   macrophage
ID DEPENDENT DIABETES-MELLITUS; ENDOTHELIAL-CELLS; OXIDATIVE STRESS;
   UP-REGULATION; RISK-FACTORS; P38 MAPK; FOXO1; MICE; ATHEROSCLEROSIS;
   METABOLISM
AB Objective: The accumulation of lipids in macrophages contributes to the development of atherosclerosis. Strategies to reduce lipid accumulation in macrophages may have therapeutic potential for preventing and treating atherosclerosis and cardiovascular complications. The antidiabetic drug metformin has been reported to reduce lipid accumulation in adipocytes. In this study, we examined the effects of metformin on lipid accumulation in macrophages and investigated the mechanisms involved. Methods and results: We observed that metformin significantly reduced palmitic acid (PA)-induced intracellular lipid accumulation in macrophages. Metformin promoted the expression of carnitine palmitoyltransferase I (CPT-1), while reduced the expression of fatty acid-binding protein 4 (FABP4) which was involved in PA-induced lipid accumulation. Quantitative real-time PCR showed that metformin regulates FABP4 expression at the transcriptional level. We identified forkhead transcription factor FOXO1 as a positive regulator of FABP4 expression. Inhibiting FOXO1 expression with FOXO1 siRNA significantly reduced basal and PA-induced FABP4 expression. Overexpression of wild-type FOXO1 and constitutively active FOXO1 significantly increased FABP4 expression, whereas dominant negative FOXO1 dramatically decreased FABP4 expression. Metformin reduced FABP4 expression by promoting FOXOI nuclear exclusion and subsequently inhibiting its activity. Conclusions: Taken together, these results suggest that metformin reduces lipid accumulation in macrophages by repressing FOXO1-mediated FABP4 transcription. Thus, metformin may have a protective effect against lipid accumulation in macrophages and may serve as a therapeutic agent for preventing and treating atherosclerosis in metabolic syndrome. (C) 2010 Elsevier Inc. All rights reserved.
C1 [Song, Jun; Ren, Pingping; Zhang, Lin; Wang, Xing Li; Shen, Ying H.] St Lukes Episcopal Hosp, Texas Heart Inst, Houston, TX 77030 USA.
   [Song, Jun; Wang, Xing Li; Chen, Li] Shandong Univ, Qilu Hosp, Jinan 250100, Shandong, Peoples R China.
   [Song, Jun; Ren, Pingping; Zhang, Lin; Wang, Xing Li; Shen, Ying H.] Baylor Coll Med, Michael E DeBakey Dept Surg, Div Cardiothorac Surg, Houston, TX 77030 USA.
C3 Saint Lukes Episcopal Hospital; Texas Heart Institute; Shandong
   University; Baylor College of Medicine
RP Shen, YH (corresponding author), St Lukes Episcopal Hosp, Texas Heart Inst, C-1095,6770 Bertner Ave, Houston, TX 77030 USA.
EM hyshen@bcm.edu
RI shen, ying/HHS-5635-2022; wang, xingli/MHR-1399-2025
FU  [AHA-TX 0565134Y];  [AHA-0730190N]
FX The authors thank Nicole Stancel, Ph.D., of the Texas Heart Institute at
   St. Luke's Episcopal Hospital for editorial assistance in the
   preparation of this manuscript. This study was supported by grants
   AHA-TX 0565134Y (YHS) and AHA-0730190N (YHS).
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NR 35
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Z9 59
U1 0
U2 25
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0006-291X
EI 1090-2104
J9 BIOCHEM BIOPH RES CO
JI Biochem. Biophys. Res. Commun.
PD FEB 26
PY 2010
VL 393
IS 1
BP 89
EP 94
DI 10.1016/j.bbrc.2010.01.086
PG 6
WC Biochemistry & Molecular Biology; Biophysics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics
GA 566LI
UT WOS:000275371300017
PM 20102700
DA 2025-06-11
ER

PT J
AU Ros, E
AF Ros, Emilio
TI Nuts and novel biomarkers of cardiovascular disease
SO AMERICAN JOURNAL OF CLINICAL NUTRITION
LA English
DT Article; Proceedings Paper
CT 5th International Congress on Vegetarian Nutrition
CY MAR, 2008
CL Loma Linda Univ, Loma Linda, CA
HO Loma Linda Univ
ID ALPHA-LINOLENIC ACID; IMPROVES ENDOTHELIAL FUNCTION; LOW-DENSITY
   LIPOPROTEINS; CORONARY-HEART-DISEASE; C-REACTIVE PROTEIN; RISK-FACTORS;
   METABOLIC SYNDROME; OXIDATIVE STRESS; LIPID PROFILE;
   HYPERCHOLESTEROLEMIC MEN
AB Nuts are energy-dense foods, rich in total fat and unsaturated fatty acids. The favorable fatty acid profile probably contributes to the beneficial effects of nut consumption observed in epidemiologic studies (prevention of coronary heart disease and diabetes) and feeding trials (cholesterol lowering). Besides fat, the complex matrices of nuts contain many bioactive compounds: vegetable protein, fiber, minerals, tocopherols, and phenolic compounds. By virtue of their unique composition, nuts are likely to benefit newer cardiovascular risk biomarkers, such as LDL oxidizability, soluble inflammatory molecules, and endothelial dysfunction. Protection of LDL oxidation by nut intake has been documented in some, but not all, clinical studies. In one study, feeding one daily serving of mixed nuts was associated with lower oxidized LDL concentrations. Regarding inflammation, cross-sectional studies have shown that nut consumption is associated with lower concentrations of circulating inflammatory molecules and higher plasma adiponectin, a potent antiinflammatory adipokine. Clinical studies with nuts have documented reduced inflammatory cytokine concentrations but no consistent changes of C-reactive protein. Only walnuts have been formally tested for effects on endothelial function. After both walnut diets and single walnut meals, favorable vasoreactivity changes have been observed. Walnut consumption also reduced expression of endothelin 1, a potent endothelial activator, in an animal model of accelerated atherosclerosis. Beneficial effects on vascular reactivity may be ascribed to several constituents of walnuts: L-arginine, the precursor of nitric oxide, a-linolenic acid, and phenolic antioxidants. Although more studies are warranted, the emerging picture is that nut consumption beneficially influences cardiovascular risk beyond cholesterol lowering. Am J Clin Nutr 2009; 89(suppl): 1649S-56S.
C1 [Ros, Emilio] Hosp Clin Barcelona, Inst Invest Biomed August Pi Sunyer, Endocrinol & Nutr Serv, Lipid Clin, Barcelona 08036, Spain.
   [Ros, Emilio] Inst Salud Carlos III, CIBEROBN, Barcelona, Spain.
C3 University of Barcelona; Hospital Clinic de Barcelona; IDIBAPS;
   Instituto de Salud Carlos III; CIBER - Centro de Investigacion Biomedica
   en Red; CIBEROBN
RP Ros, E (corresponding author), Hosp Clin Barcelona, Inst Invest Biomed August Pi Sunyer, Endocrinol & Nutr Serv, Lipid Clin, Villarroel 170, Barcelona 08036, Spain.
EM eros@clinic.ub.es
OI Ros, Emilio/0000-0002-2573-1294
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NR 101
TC 203
Z9 217
U1 0
U2 26
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0002-9165
EI 1938-3207
J9 AM J CLIN NUTR
JI Am. J. Clin. Nutr.
PD MAY 1
PY 2009
VL 89
IS 5
BP S1649
EP S1656
DI 10.3945/ajcn.2009.26736R
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Nutrition & Dietetics
GA 436EB
UT WOS:000265394300057
PM 19321561
OA Bronze
DA 2025-06-11
ER

PT J
AU Van Cauter, E
   Splegel, K
   Tasali, E
   Leproult, R
AF Van Cauter, Eve
   Splegel, Karine
   Tasali, Esra
   Leproult, Rachel
TI Metabolic consequences of sleep and sleep loss
SO SLEEP MEDICINE
LA English
DT Article
DE Sleep deprivation; Glucose metabolism; Diabetes; Appetite regulation;
   Leptin; Ghrelin; Obesity
ID BODY-MASS INDEX; SLOW-WAVE SLEEP; LEPTIN LEVELS; RISK-FACTORS;
   ENVIRONMENTAL-FACTORS; INSULIN-RESISTANCE; OLDER-ADULTS; WEIGHT-GAIN;
   OBESITY; DURATION
AB Reduced sleep duration and quality appear to be endemic in modern society. Curtailment of the bedtime period to minimum tolerability is thought to be efficient and harmless by many. It has been known for several decades that sleep is a major modulator of hormonal release, glucose regulation and cardiovascular function. In particular, slow wave sleep (SWS), thought to be the most restorative sleep stage, is associated with decreased heart rate, blood pressure, sympathetic nervous activity and cerebral glucose utilization, compared with wakefulness. During SWS, the anabolic growth hormone is released while the stress hormone cortisol is inhibited. In recent years, laboratory and epidemiologic evidence have converged to indicate that sleep loss may be a novel risk factor for obesity and type 2 diabetes. The increased risk of obesity is possibly linked to the effect of sleep loss on hormones that play a major role in the central control of appetite and energy expenditure, Such as leptin and ghrelin. Reduced leptin and increased ghrelin levels correlate with increases in Subjective hunger when individuals are sleep restricted rather than well rested. Given the evidence, sleep curtailment appears to be ail important, yet modifiable, risk factor for the metabolic syndrome, diabetes and obesity. The marked decrease in average sleep duration in the last 50 years coinciding with the increased prevalence of obesity, together with the observed adverse effects of recurrent partial sleep deprivation oil metabolism and hormonal processes, may have important implications for public health. (C) 2008 Published by Elsevier B.V. All rights reserved.
C1 [Van Cauter, Eve; Tasali, Esra; Leproult, Rachel] Univ Chicago, Dept Med, Chicago, IL 60637 USA.
   [Splegel, Karine] Univ Lyon 1, Fac Med, Dept Expt Med, INSERM,UCBL,U628, F-69373 Lyon, France.
C3 University of Chicago; Institut National de la Sante et de la Recherche
   Medicale (Inserm); Universite Claude Bernard Lyon 1
RP Van Cauter, E (corresponding author), Univ Chicago, Dept Med, MC 1027,5841 S Maryland Ave, Chicago, IL 60637 USA.
EM evcauter@medicine.bsd.uchicago.edu
RI Spiegel, Karine/H-4456-2017
OI Spiegel, Karine/0000-0003-0193-0886
FU NIH [PO1 AG-11412, ROI HL-075079, P60 DK-20595]; US Department of
   Defence [W81XWH-07-2-0071]
FX Work partly Supported by NIH grants PO1 AG-11412, ROI HL-075079 and P60
   DK-20595 and by grant W81XWH-07-2-0071 of the US Department of Defence.
   We thank Matt Weitz, from Wolters Kluwer Health, who provided medical
   writing Support on behalf of sanofi-aventis.
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NR 49
TC 535
Z9 610
U1 3
U2 107
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1389-9457
EI 1878-5506
J9 SLEEP MED
JI Sleep Med.
PD SEP
PY 2008
VL 9
SU 1
BP S23
EP S28
DI 10.1016/S1389-9457(08)70013-3
PG 6
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 371GV
UT WOS:000260820700005
PM 18929315
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Bourebaba, L
   Bourebaba, N
   Galuppo, L
   Marycz, K
AF Bourebaba, Lynda
   Bourebaba, Nabila
   Galuppo, Larry
   Marycz, Krzysztof
TI Artificial mitochondrial transplantation (AMT) reverses aging of
   mesenchymal stromal cells and improves their immunomodulatory properties
   in LPS-induced synoviocytes inflammation
SO BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
LA English
DT Article
DE ASCs; EMS; Aging; Senescence; AMT; Immunomodulation
ID STEM-CELLS; DYSFUNCTION; MODELS; AUTOPHAGY; THERAPY; FISSION; FUSION;
   INJURY; MIRO1
AB Nowadays, regenerative medicine techniques are usually based on the application of mesenchymal stromal cells (MSCs) for the repair or restoration of injured damaged tissues. However, the effectiveness of autologous therapy is limited as therapeutic potential of MSCs declines due to patient's age, health condition and prolonged in vitro cultivation as a result of decreased growth rate. For that reason, there is an urgent need to develop strategies enabling the in vitro rejuvenation of MSCs prior transplantation in order to enhance their in vivo therapeutic efficiency. In presented study, we attempted to mimic the naturally occurring mitochondrial transfer (MT) between neighbouring cells and verify whether artificial MT (AMT) could reverse MSCs aging and improve their biological properties. For that reason, mitochondria were isolated from healthy donor equine adipose-derived stromal cells (ASCs) and transferred into metabolically impaired recipient ASCs derived from equine metabolic syndrome (EMS) affected horses, which were subsequently subjected to various analytical methods in order to verify the cellular and molecular outcomes of the applied AMT. Mitochondria recipient cells were characterized by decreased apoptosis, senescence and endoplasmic reticulum stress while insulin sensitivity was enhanced. Furthermore, we observed increased mitochondrial fragmentation and associated PARKIN protein accumulation, which indicates on the elimination of dysfunctional organelles via mitophagy. AMT further promoted physioxia and regulated autophagy fluxes. Additionally, rejuvenated ASCs displayed an improved anti-inflammatory activity toward LPS-stimulated synoviocytes. The presented findings highlight AMT as a promising alternative and effective method for MSCs rejuvenation, for potential application in autologous therapies in which MSCs properties are being strongly deteriorated due to patients' condition.
C1 [Bourebaba, Lynda; Bourebaba, Nabila; Marycz, Krzysztof] Wroclaw Univ Environm & Life Sci, Dept Expt Biol, Norwida 27B, PL-50375 Wroclaw, Poland.
   [Galuppo, Larry] Univ Calif Davis, Sch Vet Med, Dept Surg & Radiol Sci, Davis, CA 95516 USA.
   [Marycz, Krzysztof] Univ Calif Davis, Vet Inst Regenerat Cures, Sch Vet Med, Dept Vet Med & Epidemiol, Davis, CA 95616 USA.
C3 Wroclaw University of Environmental & Life Sciences; University of
   California System; University of California Davis; University of
   California System; University of California Davis
RP Bourebaba, L; Marycz, K (corresponding author), Univ Environm & Life Sci, Fac Biol & Anim Sci, Dept Expt Biol, Norwida 27B, PL-50375 Wroclaw, Poland.
EM lynda.bourebaba@upwr.edu.pl; krzysztof.marycz@upwr.edu.pl
RI Marycz, Krzysztof/A-2249-2017; Bourebaba, Nabila/JRY-9553-2023;
   Bourebaba, Lynda/AAX-7613-2020
FU National Science Centre in Poland [2021/43/B/NZ7/02963]; Polish National
   Agency for Academic Exchange (NAWA); Wroclaw University of Environmental
   and Life Sciences
FX The work was supported by a grant obtained from the National Science
   Centre in Poland over the course of the realization of the project
   "Mitotherapy as a novel strategy for the modulation of immunometabolic
   phenotype of fibroblast-like synoviocytes (FLS CD34-THY1 +) - a new
   avenue for the treatment of synovitis in horses" (2021/43/B/NZ7/02963) .
   This research was also supported by The Polish National Agency for
   Academic Exchange (NAWA) by sponsoring the Bakker program internship at
   University of California in Davis. The APC was co-financed by Wroclaw
   University of Environmental and Life Sciences.
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NR 89
TC 2
Z9 2
U1 2
U2 9
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0167-4889
EI 1879-2596
J9 BBA-MOL CELL RES
JI Biochim. Biophys. Acta-Mol. Cell Res.
PD OCT
PY 2024
VL 1871
IS 7
AR 119806
DI 10.1016/j.bbamcr.2024.119806
EA AUG 2024
PG 19
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA C6L2W
UT WOS:001290460600001
PM 39098401
OA hybrid
DA 2025-06-11
ER

PT J
AU Antonelli, M
   Donelli, D
   Gurgoglione, FL
   Lazzeroni, D
   Halasz, G
   Niccoli, G
AF Antonelli, Michele
   Donelli, Davide
   Gurgoglione, Filippo Luca
   Lazzeroni, Davide
   Halasz, Geza
   Niccoli, Giampaolo
TI Effects of Static Meditation Practice on Blood Lipid Levels: A
   Systematic Review and Meta-Analysis
SO HEALTHCARE
LA English
DT Review
DE meditation; cholesterol; triglycerides; blood lipids; cardiovascular
   prevention; health promotion; review
ID QIGONG TRAINING-PROGRAM; TRANSCENDENTAL-MEDITATION; METABOLIC SYNDROME;
   CARDIOVASCULAR-DISEASE; STRESS REDUCTION; CONTROLLED-TRIAL; ZEN
   MEDITATION; HEALTH; CHOLESTEROL; PREVENTION
AB This review aims to delineate the potential impact of static meditation practice on cholesterol and triglyceride levels. PubMed, EMBASE, Web of Science, Cochrane Library, and Google Scholar were systematically screened up until December 2023 to identify pertinent studies. After searching the scientific literature, 16 clinical studies (11 trials and 5 observational experiments) met the criteria for inclusion, involving a total of 1147 participants. In general, Ayurvedic-based meditation techniques were predominantly associated with lower total cholesterol levels, mindfulness-based techniques demonstrated benefits in both total cholesterol and triglyceride levels, and Eastern meditation techniques with spiritual origins were primarily linked to improved serum concentrations of HDL cholesterol. Study participants mostly engaged in meditation on a daily basis, often practicing it once or even twice a day, spanning a duration ranging from a few weeks to several months. The meta-analysis shows an association between meditation practice in healthy or sub-healthy adults and reduced cholesterol levels, with an average decrease of approximately -14 mg/dL (MD = -13.91 [-23.35; -4.47] mg/dL; p = 0.02), alongside favorable and even more pronounced impacts on triglyceride levels (MD = -32.56 [-48.44; -16.68] mg/dL; p < 0.01). In summary, regular engagement in static meditation practices can be associated with lower triglyceride and, to a lesser extent, cholesterol levels. Further studies on the topic are recommended to better investigate the relationship between meditation practice and physiological parameters.
C1 [Antonelli, Michele] AUSL IRCCS Reggio Emilia, Dept Publ Hlth, I-42122 Reggio Emilia, Italy.
   [Donelli, Davide; Gurgoglione, Filippo Luca; Niccoli, Giampaolo] Univ Hosp Parma, Cardiol Unit, I-43126 Parma, Italy.
   [Lazzeroni, Davide] IRCCS Fdn Don Gnocchi, Prevent & Rehabil Unit, I-43100 Parma, Italy.
   [Halasz, Geza] AO San Camillo Forlanini, Dept Cardiothorac & Vasc Med & Surg, Div Cardiol, I-00152 Rome, Italy.
C3 University of Parma; University Hospital of Parma; Azienda Ospedaliera
   San Camillo-Forlanini
RP Antonelli, M (corresponding author), AUSL IRCCS Reggio Emilia, Dept Publ Hlth, I-42122 Reggio Emilia, Italy.
EM michele.antonelli@ausl.re.it
RI Lazzeroni, Davide/AAC-1611-2019; Donelli, Davide/AAB-6495-2020
OI Donelli, Davide/0000-0002-7895-2840; Lazzeroni,
   Davide/0000-0001-9171-118X
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NR 78
TC 2
Z9 2
U1 1
U2 12
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2227-9032
J9 HEALTHCARE-BASEL
JI Healthcare
PD MAR
PY 2024
VL 12
IS 6
AR 655
DI 10.3390/healthcare12060655
PG 19
WC Health Care Sciences & Services; Health Policy & Services
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services
GA MK0C9
UT WOS:001193387900001
PM 38540618
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Hamada, R
   Funasaka, Y
   Saeki, H
   Serizawa, N
   Hagino, T
   Yano, Y
   Mitsui, H
   Kanda, N
AF Hamada, Risa
   Funasaka, Yoko
   Saeki, Hidehisa
   Serizawa, Naotaka
   Hagino, Teppei
   Yano, Yumiko
   Mitsui, Hiroshi
   Kanda, Naoko
TI Dietary habits in adult Japanese patients with vitiligo
SO JOURNAL OF DERMATOLOGY
LA English
DT Article
DE age; body mass index; dietary habit; male; vitiligo
ID METABOLIC SYNDROME; OXIDATIVE STRESS; INTERFERON-GAMMA; VITAMIN-D;
   MELANOGENESIS; CELLS; ACTIVATION; MANGANESE; SERUM
AB Vitiligo is an autoimmune skin disease with acquired depigmentation. Dietary habits may modulate the pathogenesis of vitiligo. We evaluated dietary habits in adult Japanese patients with nonsegmental vitiligo, and compared their results with those of age- and sex-matched controls. We also examined the relationship between dietary habits and Vitiligo Area Scoring Index (VASI), or vitiligo on different anatomical sites. The intakes of energy, nutrients, and foods in the participants were analyzed using a brief-type self-administered diet history questionnaire. Patients with vitiligo showed higher body mass index (BMI) and lower intakes of manganese, vitamin D, pulses, and confection, compared with controls. Multivariate logistic regression analysis showed that vitiligo was associated with high BMI. VASI was higher in males than in females, and negatively correlated with age or intakes of potatoes and vegetables other than green/yellow vegetables. Linear multivariate regression analysis showed that high VASI was associated with younger age. Multivariate logistic regression analysis showed that moderate to severe vitiligo (VASI >= 4.25) was associated with male sex and longer disease duration. Multivariate logistic regression analyses showed the following association with vitiligo on respective anatomical sites: high intake of eggs and dairy products and high VASI on the head or neck, high intake of oils and fats and high VASI on the trunk, high intake of cereals and high VASI on the upper limbs, male sex and high VASI on the lower limbs, and high BMI and high VASI on the hands or feet. In conclusion, the control of obesity might have prophylactic or therapeutic effects on vitiligo.
C1 [Hamada, Risa; Funasaka, Yoko; Saeki, Hidehisa] Nippon Med Sch, Dept Dermatol, Tokyo, Japan.
   [Serizawa, Naotaka; Hagino, Teppei; Kanda, Naoko] Nippon Med Sch, Chiba Hokusoh Hosp, Dept Dermatol, Inzai, Japan.
   [Yano, Yumiko; Mitsui, Hiroshi] Tokyo Teishin Hosp, Tokyo, Japan.
   [Kanda, Naoko] Nippon Med Sch, Chiba Hokusoh Hosp, Dept Dermatol, Kamagari 1715, Inzai, Chiba 2701694, Japan.
C3 Nippon Medical School; Nippon Medical School; Nippon Medical School
RP Kanda, N (corresponding author), Nippon Med Sch, Chiba Hokusoh Hosp, Dept Dermatol, Kamagari 1715, Inzai, Chiba 2701694, Japan.
EM n-kanda@nms.ac.jp
RI Hagino, Teppei/ITT-2641-2023; Kanda, Naoko/ISV-0667-2023
OI Hagino, Teppei/0000-0002-4183-9596; Saeki, Hidehisa/0000-0002-1095-0355
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NR 50
TC 4
Z9 4
U1 2
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0385-2407
EI 1346-8138
J9 J DERMATOL
JI J. Dermatol.
PD APR
PY 2024
VL 51
IS 4
BP 491
EP 508
DI 10.1111/1346-8138.17163
EA FEB 2024
PG 18
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA MS2S8
UT WOS:001175424900001
PM 38421796
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Lin, MW
   Yu, XR
   Chen, JY
   Wei, YS
   Chen, HY
   Tsai, YT
   Lin, LH
   Liao, EC
   Kung, HY
   Young, SS
   Chan, HL
   Chou, HC
AF Lin, Meng -Wei
   Yu, Xin-Ru
   Chen, Jai -Yu
   Wei, Yu -Shan
   Chen, Hsin-Yi
   Tsai, Yi-Ting
   Lin, Li-Hsun
   Liao, En -Chi
   Kung, Hsiang-Yu
   Young, Shuh-Sen
   Chan, Hong -Lin
   Chou, Hsiu-Chuan
TI Sediment pollutant exposures caused hepatotoxicity and disturbed
   glycogenesis
SO ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
LA English
DT Article
DE Sediment; Environmental pollution; Liver damage; Glycogenesis; Apoptosis
ID GLUCOSE-METABOLISM; OXIDATIVE STRESS; ACTIVATION; LIVER;
   BIOACCUMULATION; ROS
AB Liver metabolic syndrome, which involves impaired hepatic glycogen synthesis, is persistently increased by exposure to environmental pollutants. Most studies have investigated the pathogenesis of liver damage caused by single metal species or pure organics. However, under normal circumstances, the pollutants that we are exposed to are usually chemical mixtures that accumulate over time. Sediments are long-term repositories for environ-mental pollutants due to their environmental cycles, which make them good samples for evaluating the effect of environmental pollutants on the liver via bioaccumulation. This study aimed to clarify the effects of sediment pollutants on liver damage. Our results indicate that industrial wastewater sediment (downstream) is more cytotoxic than sediments from other zones. Downstream sediment extract (DSE) causes hepatotoxicity, stimulates reactive oxygen species (ROS) generation, triggers mitochondrial dysfunction, induces cell apoptosis, and results in the release of glutamic oxaloacetic transaminase (GOT) and glutamic pyruvic transaminase (GPT) proteins. Additionally, to elucidate the underlying mechanism by which sediment pollutants disturb hepatic glycogen synthesis, we investigated the effects of different sediment samples from different pollution situations on glycogen synthesis in liver cell lines. It was found that DSE induced multiple severe impairments in liver cells, and disturbed glycogen synthesis more than under other conditions. These impairments include decreased he-patic glycogen synthesis via inhibition and insulin receptor substrate 1 (IRS-1) /AKT /glycogen synthase kin-ase38 (GSK38)-mediated glycogen synthase (GYS) inactivation. To our knowledge, this study provides the first detailed evidence of in vitro sediment-accumulated toxicity that interferes with liver glycogen synthesis, leading to hepatic cell damage through apoptosis.
C1 [Lin, Meng -Wei; Wei, Yu -Shan; Chen, Hsin-Yi; Tsai, Yi-Ting; Lin, Li-Hsun; Liao, En -Chi; Chan, Hong -Lin] Natl Tsing Hua Univ, Inst Bioinformat & Struct Biol, Hsinchu, Taiwan.
   [Yu, Xin-Ru; Chen, Jai -Yu; Kung, Hsiang-Yu; Young, Shuh-Sen; Chou, Hsiu-Chuan] Natl Tsing Hua Univ, Inst Analyt & Environm Sci, Hsinchu, Taiwan.
   [Chan, Hong -Lin] Natl Tsing Hua Univ, Inst Bioinformat & Struct Biol, Dept Med Sci, Hsinchu, Taiwan.
C3 National Tsing Hua University; National Tsing Hua University; National
   Tsing Hua University
RP Chan, HL (corresponding author), Natl Tsing Hua Univ, Inst Bioinformat & Struct Biol, Hsinchu, Taiwan.; Chou, HC (corresponding author), Natl Tsing Hua Univ, Inst Analyt & Environm Sci, Hsinchu, Taiwan.
EM hlchan@life.nthu.edu.tw; chouhc@mx.nthu.edu.tw
RI Lin, Meng-Wei/HZH-4299-2023; EnChi, Liao/HGU-1740-2022; YU,
   Xinru/AAP-7599-2021; 周, 建良/HLV-8728-2023
FU National Science and Technology Council (NSTC) [106-2221-E-007-015-MY3]
FX This work was supported by National Science and Technology Council
   (NSTC) grant - 106-2221-E-007-015-MY3, Taiwan.
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NR 39
TC 4
Z9 4
U1 0
U2 10
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0147-6513
EI 1090-2414
J9 ECOTOX ENVIRON SAFE
JI Ecotox. Environ. Safe.
PD FEB
PY 2023
VL 251
AR 114559
DI 10.1016/j.ecoenv.2023.114559
EA JAN 2023
PG 10
WC Environmental Sciences; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Toxicology
GA E4GD8
UT WOS:000975134700001
PM 36669277
OA gold
DA 2025-06-11
ER

PT J
AU D'Archivio, M
   Santangelo, C
   Silenzi, A
   Scazzocchio, B
   Varì, R
   Masella, R
AF D'Archivio, Massimo
   Santangelo, Carmela
   Silenzi, Annalisa
   Scazzocchio, Beatrice
   Vari, Rosaria
   Masella, Roberta
TI Dietary EVOO Polyphenols and Gut Microbiota Interaction: Are There Any
   Sex/Gender Influences?
SO ANTIOXIDANTS
LA English
DT Review
DE extra virgin olive oil; polyphenols; gut microbiota; sex; gender; diet
ID VIRGIN OLIVE OIL; PHENOLIC-COMPOUNDS; LACTOBACILLUS-PLANTARUM; IN-VITRO;
   BIOLOGICAL-ACTIVITY; MEDITERRANEAN DIET; METABOLIC SYNDROME; OXIDATIVE
   STRESS; FECAL MICROBIOTA; HYDROXYTYROSOL
AB Accumulating evidence indicates that regular consumption of extra virgin olive oil (EVOO), the main source of fat in the Mediterranean diet, is associated with beneficial health effects and a reduced risk of developing chronic degenerative disorders. The beneficial effects of EVOO can be attributed to its unique composition in monounsaturated fats and phenolic compounds that provide important antioxidant, anti-inflammatory, and immune-modulating activities. On the other hand, it is well known that the gut microbiota has several important roles in normal human physiology, and its composition can be influenced by a multitude of environmental and lifestyle factors, among which dietary components play a relevant role. In the last few years, the two-way interaction between polyphenols, including those in EVOO, and the gut microbiota, i.e., the modulation of the microbiota by polyphenols and that of polyphenol metabolism and bioavailability by the microbiota, has attracted growing attention, being potentially relevant to explain the final effects of polyphenols, as well as of the microbiota profile. Furthermore, sex and gender can affect dietary habits, polyphenol intake, and nutrient metabolism. Lastly, it has been recently suggested that differences in gut microbiota composition could be involved in the unequal incidence of metabolic diseases observed between women and men, due to sex-dependent effects on shaping gut microbiota profiles according to diet. This review summarizes the most recent studies on the relationship between EVOO polyphenols and the gut microbiota, taking into account possible influences of sex and gender in modulating such an interaction.
C1 [D'Archivio, Massimo; Santangelo, Carmela; Silenzi, Annalisa; Scazzocchio, Beatrice; Vari, Rosaria; Masella, Roberta] Ist Super Sanita, Gender Specif Prevent & Hlth Unit, Ctr Gender Specif Med, I-00161 Rome, Italy.
C3 Istituto Superiore di Sanita (ISS)
RP Santangelo, C (corresponding author), Ist Super Sanita, Gender Specif Prevent & Hlth Unit, Ctr Gender Specif Med, I-00161 Rome, Italy.
EM carmela.santangelo@iss.it
RI VARI', ROSARIA/B-4111-2015; D'ARCHIVIO, MASSIMO/B-4106-2015; Masella,
   Roberta/B-4109-2015; scazzocchio, beatrice/B-4110-2015; SANTANGELO,
   CARMELA/D-5726-2011
OI SANTANGELO, CARMELA/0000-0002-4309-1745; Silenzi,
   Annalisa/0000-0001-9589-7460; Rosaria, Vari/0000-0003-0488-6702;
   Scazzocchio, Beatrice/0000-0002-5123-3897; D'Archivio,
   Massimo/0000-0001-8104-3421; Masella, Roberta/0000-0002-3173-1573
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NR 176
TC 12
Z9 12
U1 3
U2 14
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD SEP
PY 2022
VL 11
IS 9
AR 1744
DI 10.3390/antiox11091744
PG 26
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA 4T4HS
UT WOS:000858081100001
PM 36139818
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Uhunmwangho, EG
   Oniyide, AA
   Areloegbe, SE
   Soetan, OA
   Akintayo, CO
   Aturamu, A
   Olaniyi, KS
AF Uhunmwangho, Efosa G.
   Oniyide, Adesola A.
   Areloegbe, Stephanie E.
   Soetan, Olaniyi A.
   Akintayo, Christopher O.
   Aturamu, Ayodeji
   Olaniyi, Kehinde S.
TI Mineralocorticoid receptor blockade attenuates hyperandrogenic metabolic
   dysregulation in letrozole-induced PCOS rat model
SO JOURNAL OF DIABETES AND METABOLIC DISORDERS
LA English
DT Article
DE Hyperandrogenism; Letrozole; Mineralocorticoid receptor; PCOS
   Spironolactone
ID POLYCYSTIC-OVARY-SYNDROME; LOW-DOSE SPIRONOLACTONE; OXIDATIVE STRESS;
   INSULIN-RESISTANCE; OBESE WOMEN; ATHEROSCLEROSIS; OVERWEIGHT;
   GENERATION; CANCER
AB Purpose Polycystic ovarian syndrome (PCOS) is a metabolic syndrome associated with mineralocorticoid receptor (MR) activation, which causes infertility in women of reproductive age. Spironolactone (SPL) is a MR blocker with inconclusive effect in the treatment of PCOS. Therefore, the present study hypothesized that low dose SPL would ameliorate metabolic dysfunction associated with PCOS.
   Methods Female Wistar rats (8-week-old) were divided into 3 groups namely: Control, SPL, Letrozole (LET)-treated and LET + SPL-treated groups. The control group was given vehicle (distilled water), SPL-treated group received 0.25 mg/kg, LET-treated group received 1 mg/kg of LET and LET + SPL-treated group received a combination of LET and SPL. The administrations were done by oral gavage for 21 days uninterruptedly. Biochemical parameters such as lipid profile, malondialdehyde (MDA), tumor necrosis factor-alpha (TNF-alpha), gamma-glutamyl transferase (GGT), lactate dehydrogenase (LDH), testosterone, 17-beta estradiol and glutathione peroxidase (GPx) were determined with appropriate assay methods.
   Results Letrozole-treated group had a significant increase in ovarian weight, plasma and ovarian triglycerides, MDA/TNF-alpha, GGT/LDH and plasma testosterone while it decreased plasma 17-beta estradiol and plasma/ovarian high-density lipoproteins and GPx when compared with control group. In addition, histomorphological changes were observed in LET-treated group compared with control group. Nevertheless, administration of low dose SPL attenuated these perturbations.
   Conclusion The present study therefore demonstrates that inhibition of mineralocorticoid receptor by low dose SPL ameliorates hyperandrogenic metabolic dysfunction in a rat model of PCOS. Therefore, low dose SPL is hereby suggested as a promising therapeutic agent in the management of PCOS.
C1 [Uhunmwangho, Efosa G.; Oniyide, Adesola A.; Areloegbe, Stephanie E.; Akintayo, Christopher O.; Aturamu, Ayodeji; Olaniyi, Kehinde S.] Afe Babalola Univ, Coll Med & Hlth Sci, Dept Physiol, Cardio Reprometab & Microbiome Res Unit, Ado Ekiti 360101, Nigeria.
   [Soetan, Olaniyi A.] Thomas Adewumi Univ, Coll Hlth Sci, Dept Physiol, Oko, Nigeria.
RP Olaniyi, KS (corresponding author), Afe Babalola Univ, Coll Med & Hlth Sci, Dept Physiol, Cardio Reprometab & Microbiome Res Unit, Ado Ekiti 360101, Nigeria.
EM kennethnitty2010@gmail.com
RI Areloegbe, Stephanie/HSH-5245-2023; Olaniyi, Kehinde/GPK-5850-2022
OI Olaniyi, Kehinde/0000-0002-8229-9688
CR Abbott DH, 2013, FERTIL STERIL, V100, P2, DOI 10.1016/j.fertnstert.2013.05.023
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NR 35
TC 2
Z9 2
U1 0
U2 2
PU SPRINGER INT PUBL AG
PI CHAM
PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND
EI 2251-6581
J9 J DIABETES METAB DIS
JI J. Diabetes Metab. Disord.
PD DEC
PY 2022
VL 21
IS 2
BP 1539
EP 1547
DI 10.1007/s40200-022-01097-x
EA JUL 2022
PG 9
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA 6G9RJ
UT WOS:000825161900001
PM 36404823
OA Green Published
DA 2025-06-11
ER

PT J
AU Ali, AI
   Hassan, WNM
   Alrawi, S
AF Ali, Alaa Ibrahim
   Hassan, Wassan Nori Mohammed
   Alrawi, Sumaya
TI A Copeptin as a Predictor Marker for Insulin Resistance Among Women with
   Polycystic Ovary Syndrome
SO CURRENT WOMENS HEALTH REVIEWS
LA English
DT Article
DE Polycystic ovarian syndrome; plasma copeptin; insulin resistance;
   metabolic syndrome; arginine vasopressin; Copeptin
ID PLASMA COPEPTIN; PATHOPHYSIOLOGY; STRESS; RISK
AB Background: A polycystic ovarian syndrome ( PCOS) is a common endocrine syndrome in which women have a wide range of clinical presentations; insulin resistance was linked to its pathogenesis.
   Objective: We aimed to investigate the copeptin role as a predictive marker of insulin resistance among PCOS women.
   Materials and Methods: In University Hospital, we included 280 women, with 140 of them being healthy controls. 140 out of 280 cases of PCOS subdivided into two groups depending on the insulin resistance; group 1 with homeostasis model assessment for the insulin resistance < 2.5. Group 2 with homeostasis model assessment for the insulin resistance >2.5. The evaluation of body mass index and blood pressure for all besides the blood sampling for estimation of a follicular stimulating hormone, luteinizing hormone, prolactin, estradiol, sex hormone-binding globulin, total testosterone, fasting insulin dehydroepiandrosterone sulfate, C-reactive protein, plasma glucose, free androgen index, and plasma copeptin using the Copeptin-Human EIA Kit besides the transvaginal ultrasound for ovarian assessment.
   Results: When compared to other groups, PCOS women with positive insulin resistance >2.5 had a significantly higher plasma copeptin level. The ROC curve calculated a 1.94 pmol/L; plasma copeptin cutoff value for detecting the insulin resistance in PCOS with 88 % sensitivity value and 36 % specificity, AUC was 0.88.
   Conclusion: The significant positive relationship between serum copeptin and insulin resistance with high sensitivity implies its usefulness as a marker of insulin resistance among PCOS patients with a high prediction of its complication.
C1 [Ali, Alaa Ibrahim; Hassan, Wassan Nori Mohammed] Mustansiriyah Univ, Coll Med, Dept Obstet & Gynecol, Baghdad, Iraq.
   [Alrawi, Sumaya] AL Yarmuk Teaching Hosp, Baghdad, Iraq.
C3 Mustansiriya University
RP Ali, AI (corresponding author), Mustansiriyah Univ, Coll Med, Dept Obstet & Gynecol, Baghdad, Iraq.
EM alaa.ibrabeem@umostansyriah.edu.iq
RI Ali, Alaa/AAZ-7878-2021; Nori, Wassan/AAO-5736-2020
OI Nori, Wassan/0000-0002-8749-2444; Ibrahim, Alaa/0000-0002-5461-306X
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NR 28
TC 4
Z9 4
U1 0
U2 0
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1573-4048
EI 1875-6581
J9 CURR WOMENS HEALTH R
JI Curr. Womens Health Rev.
PY 2022
VL 18
IS 4
AR e081221198670
DI 10.2174/1573404817666211208152049
PG 6
WC Obstetrics & Gynecology
WE Emerging Sources Citation Index (ESCI)
SC Obstetrics & Gynecology
GA 0Q3FG
UT WOS:000784807700007
DA 2025-06-11
ER

PT J
AU Mertens, J
   De Block, C
   Spinhoven, M
   Driessen, A
   Francque, SM
   Kwanten, WJ
AF Mertens, Jonathan
   De Block, Christophe
   Spinhoven, Maarten
   Driessen, Ann
   Francque, Sven M.
   Kwanten, Wilhelmus J.
TI Hepatopathy Associated With Type 1 Diabetes: Distinguishing
   Non-alcoholic Fatty Liver Disease From Glycogenic Hepatopathy
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Review
DE type 1 diabetes mellitus; non-alcoholic fatty liver disease; metabolic
   dysfunction-associated fatty liver disease; non-alcoholic
   steatohepatitis; glycogenic hepatopathy
ID CONTROLLED ATTENUATION PARAMETER; ALL-CAUSE MORTALITY; HEPATIC
   GLUCOSE-METABOLISM; CHRONIC KIDNEY-DISEASE; LONG-ACTING INSULIN;
   CARDIOVASCULAR-DISEASE; OXIDATIVE STRESS; MAURIAC-SYNDROME; WEIGHT-GAIN;
   INCREASED PREVALENCE
AB Autoimmune destruction of pancreatic beta-cells results in the permanent loss of insulin production in type 1 diabetes (T1D). The daily necessity to inject exogenous insulin to treat hyperglycemia leads to a relative portal vein insulin deficiency and potentiates hypoglycemia which can induce weight gain, while daily fluctuations of blood sugar levels affect the hepatic glycogen storage and overall metabolic control. These, among others, fundamental characteristics of T1D are associated with the development of two distinct, but in part clinically similar hepatopathies, namely non-alcoholic fatty liver disease (NAFLD) and glycogen hepatopathy (GlyH). Recent studies suggest that NAFLD may be increasingly common in T1D because more people with T1D present with overweight and/or obesity, linked to the metabolic syndrome. GlyH is a rare but underdiagnosed complication hallmarked by extremely brittle metabolic control in, often young, individuals with T1D. Both hepatopathies share clinical similarities, troubling both diagnosis and differentiation. Since NAFLD is increasingly associated with cardiovascular and chronic kidney disease, whereas GlyH is considered self-limiting, awareness and differentiation between both condition is important in clinical care. The exact pathogenesis of both hepatopathies remains obscure, hence licensed pharmaceutical therapy is lacking and general awareness amongst physicians is low. This article aims to review the factors potentially contributing to fatty liver disease or glycogen storage disruption in T1D. It ends with a proposal for clinicians to approach patients with T1D and potential hepatopathy.
C1 [Mertens, Jonathan; Francque, Sven M.; Kwanten, Wilhelmus J.] Antwerp Univ Hosp, Dept Gastroenterol & Hepatol, Edegem, Belgium.
   [Mertens, Jonathan; De Block, Christophe] Antwerp Univ Hosp, Dept Endocrinol Diabetol & Metab, Edegem, Belgium.
   [Mertens, Jonathan; De Block, Christophe; Francque, Sven M.; Kwanten, Wilhelmus J.] Univ Antwerp, Lab Expt Med & Pediat, Antwerp, Belgium.
   [Spinhoven, Maarten] Antwerp Univ Hosp, Dept Radiol, Edegem, Belgium.
   [Driessen, Ann] Antwerp Univ Hosp, Dept Pathol, Antwerp, Belgium.
   [Driessen, Ann] Univ Antwerp, Fac Med & Hlth Sci, CORE, Antwerp, Belgium.
C3 University of Antwerp; University of Antwerp; University of Antwerp;
   University of Antwerp; University of Antwerp; University of Antwerp
RP Mertens, J (corresponding author), Antwerp Univ Hosp, Dept Gastroenterol & Hepatol, Edegem, Belgium.; Mertens, J (corresponding author), Antwerp Univ Hosp, Dept Endocrinol Diabetol & Metab, Edegem, Belgium.; Mertens, J (corresponding author), Univ Antwerp, Lab Expt Med & Pediat, Antwerp, Belgium.
EM jonathan.mertens@uza.be
RI Mertens, Jonathan/ABQ-8432-2022; Francque, Sven/E-4526-2017; Driessen,
   Ann/HPB-7493-2023; Kwanten, Wilhelmus/GLU-4741-2022; De Block,
   Christophe/JVN-4588-2024
OI Mertens, Jonathan/0000-0002-4822-4113; De Block,
   Christophe/0000-0002-0679-3203
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NR 216
TC 26
Z9 26
U1 2
U2 14
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD OCT 25
PY 2021
VL 12
AR 768576
DI 10.3389/fphar.2021.768576
PG 20
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA WV4YJ
UT WOS:000717243800001
PM 34759828
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Hidalgo-Gutierrez, A
   Barriocanal-Casado, E
   Diaz-Casado, ME
   Gonzalez-Garcia, P
   Chiozzi, RZ
   Acuna-Castroviejo, D
   Lopez, LC
AF Hidalgo-Gutierrez, Agustin
   Barriocanal-Casado, Eliana
   Diaz-Casado, Maria Elena
   Gonzalez-Garcia, Pilar
   Zenezini Chiozzi, Riccardo
   Acuna-Castroviejo, Dario
   Lopez, Luis Carlos
TI β-RA Targets Mitochondrial Metabolism and Adipogenesis, Leading to
   Therapeutic Benefits against CoQ Deficiency and Age-Related Overweight
SO BIOMEDICINES
LA English
DT Article
DE mitochondrial disease; encephalopathy; astrogliosis; spongiosis;
   obesity; white adipose tissue; mitochondrial proteome; mouse model;
   hepatic steatosis
ID COENZYME Q(10); OXIDATIVE STRESS; RESPIRATORY-CHAIN; MECHANISMS;
   HETEROGENEITY; INHIBITION; CORRELATE; SEVERITY
AB Primary mitochondrial diseases are caused by mutations in mitochondrial or nuclear genes, leading to the abnormal function of specific mitochondrial pathways. Mitochondrial dysfunction is also a secondary event in more common pathophysiological conditions, such as obesity and metabolic syndrome. In both cases, the improvement and management of mitochondrial homeostasis remain challenging. Here, we show that beta-resorcylic acid (beta-RA), which is a natural phenolic compound, competed in vivo with 4-hydroxybenzoic acid, which is the natural precursor of coenzyme Q biosynthesis. This led to a decrease in demethoxyubiquinone, which is an intermediate metabolite of CoQ biosynthesis that is abnormally accumulated in Coq9(R239X) mice. As a consequence, beta-RA rescued the phenotype of Coq9(R239X) mice, which is a model of primary mitochondrial encephalopathy. Moreover, we observed that long-term treatment with beta-RA also reduced the size and content of the white adipose tissue (WAT) that is normally accumulated during aging in wild-type mice, leading to the prevention of hepatic steatosis and an increase in survival at the elderly stage of life. The reduction in WAT content was due to a decrease in adipogenesis, an adaptation of the mitochondrial proteome in the kidneys, and stimulation of glycolysis and acetyl-CoA metabolism. Therefore, our results demonstrate that beta-RA acted through different cellular mechanisms, with effects on mitochondrial metabolism; as such, it may be used for the treatment of primary coenzyme Q deficiency, overweight, and hepatic steatosis.</p>
C1 [Hidalgo-Gutierrez, Agustin; Barriocanal-Casado, Eliana; Diaz-Casado, Maria Elena; Gonzalez-Garcia, Pilar; Acuna-Castroviejo, Dario; Lopez, Luis Carlos] Univ Granada, Fac Med, Dept Fisiol, Granada 18016, Spain.
   [Hidalgo-Gutierrez, Agustin; Barriocanal-Casado, Eliana; Diaz-Casado, Maria Elena; Gonzalez-Garcia, Pilar; Acuna-Castroviejo, Dario; Lopez, Luis Carlos] Univ Granada, Inst Biotecnol, Ctr Invest Biomed, Granada 18016, Spain.
   [Zenezini Chiozzi, Riccardo] Univ Utrecht, Biomol Mass Spectrometry & Prote, Bijvoet Ctr Biomol Res, Utrecht Inst Pharmaceut Sci, Padualaan 8, NL-3584 CH Utrecht, Netherlands.
   [Zenezini Chiozzi, Riccardo] Netherlands Prote Ctr, Padualaan 8, NL-3584 CH Utrecht, Netherlands.
   [Lopez, Luis Carlos] Ctr Invest Biomed Red Fragilidad & Envejecimiento, Granada 18016, Spain.
C3 University of Granada; University of Granada; Utrecht University; CIBER
   - Centro de Investigacion Biomedica en Red; CIBERFES
RP Lopez, LC (corresponding author), Univ Granada, Fac Med, Dept Fisiol, Granada 18016, Spain.; Lopez, LC (corresponding author), Univ Granada, Inst Biotecnol, Ctr Invest Biomed, Granada 18016, Spain.; Lopez, LC (corresponding author), Ctr Invest Biomed Red Fragilidad & Envejecimiento, Granada 18016, Spain.
EM ahg@ugr.es; elianabc@ugr.es; elenadiaz@ugr.es; pgonzalez@ugr.es;
   r.zenezinichiozzi@uu.nl; dacuna@ugr.es; luisca@ugr.es
RI García, Pilar/X-6860-2018; Lopez, Luis/AAP-9411-2020; Gutierrez,
   Agustin/X-5891-2018; Casado, Eliana/Y-4121-2019; Lopez, Luis
   Carlos/L-5129-2014; ZENEZINI CHIOZZI, RICCARDO/I-3504-2017;
   Acuna-Castroviejo, Dario/N-7456-2016
OI Hidalgo Gutierrez, Agustin/0000-0001-6414-6859; Gonzalez Garcia,
   Pilar/0000-0002-9560-2957; Lopez, Luis Carlos/0000-0003-3355-0298;
   ZENEZINI CHIOZZI, RICCARDO/0000-0003-3904-5532; Acuna-Castroviejo,
   Dario/0000-0002-9680-1560
FU Ministerio de Ciencia e Innovacion, Spain; ERDF [RTI2018-093503-B-100];
   Muscular Dystrophy Association [MDA602322]; Junta de Andalucia
   [P20_00134]; University of Granada [UCE-PP2017-06]; EPIC-XS - Horizon
   2020 program of the European Union [823839]; Muscular Dystrophy
   Association; Junta de Andalucia; FPU program; University of Granada
FX This work was supported by grants from Ministerio de Ciencia e
   Innovacion, Spain, and the ERDF (grant number RTI2018-093503-B-100);
   from the Muscular Dystrophy Association (MDA602322); from the Junta de
   Andalucia (grant number P20_00134); from the University of Granada
   (grant reference "UNETE," UCE-PP2017-06); and by EPIC-XS, project number
   823839, funded by the Horizon 2020 program of the European Union.
   P.G.-G. is a "FPU fellow" from the Ministerio de Universidades, Spain.
   M.E.D.-C. is supported by the Muscular Dystrophy Association. E.B.-C. is
   supported by the Junta de Andalucia. A.H.-G. was partially supported by
   the "FPU program" and the research program from the University of
   Granada.
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NR 60
TC 13
Z9 13
U1 0
U2 11
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2227-9059
J9 BIOMEDICINES
JI Biomedicines
PD OCT
PY 2021
VL 9
IS 10
AR 1457
DI 10.3390/biomedicines9101457
PG 27
WC Biochemistry & Molecular Biology; Medicine, Research & Experimental;
   Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Research & Experimental Medicine;
   Pharmacology & Pharmacy
GA WR8JN
UT WOS:000714741500001
PM 34680574
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Madeira, SG
   Fernandes, C
   Paiva, T
   Moreira, CS
   Caldeira, D
AF Madeira, Sara Gamboa
   Fernandes, Carina
   Paiva, Teresa
   Moreira, Carlos Santos
   Caldeira, Daniel
TI The Impact of Different Types of Shift Work on Blood Pressure and
   Hypertension: A Systematic Review and Meta-Analysis
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Review
DE cardiovascular disease; blood pressure; occupational health; work
   schedule; permanent shift; rotating shift; night shift; systematic
   review
ID CARDIOVASCULAR RISK-FACTORS; CORONARY-ARTERY DISEASE; BODY-MASS INDEX;
   METABOLIC SYNDROME; OCCUPATIONAL NOISE; PREVALENCE; QUALITY; MARKERS;
   STRESS; HEALTH
AB Shift work (SW) encompasses 20% of the European workforce. Moreover, high blood pressure (BP) remains a leading cause of death globally. This review aimed to synthesize the magnitude of the potential impact of SW on systolic blood pressure (SBP), diastolic blood pressure (DBP) and hypertension (HTN). MEDLINE, EMBASE and CENTRAL databases were searched for epidemiological studies evaluating BP and/or HTN diagnosis among shift workers, compared with day workers. Random-effects meta-analyses were performed and the results were expressed as pooled mean differences or odds ratios and 95% confidence intervals (95% CI). The Newcastle-Ottawa Scale was used to assess the risk of bias. Forty-five studies were included, involving 117,252 workers. We found a significant increase in both SBD and DBP among permanent night workers (2.52 mmHg, 95% CI 0.75-4.29 and 1.76 mmHg, 95% CI 0.41-3.12, respectively). For rotational shift workers, both with and without night work, we found a significant increase but only for SBP (0.65 mmHg, 95% CI 0.07-1.22 and 1.28 mmHg, 95% CI 0.18-2.39, respectively). No differences were found for HTN. Our findings suggest that SW is associated with an increase of BP, mainly for permanent night workers and for SBP. This is of special interest given the large number of susceptible workers exposed over time.
C1 [Madeira, Sara Gamboa] Univ Lisbon, Fac Med, Inst Saude Ambiental ISAMB, P-1649026 Lisbon, Portugal.
   [Madeira, Sara Gamboa] Adm Reg Saude Lisboa & Vale Tejo, Family Hlth Unit Mactama, P-2745862 Lisbon, Portugal.
   [Fernandes, Carina] Univ Nova Lisboa, Escola Nacl Saude Publ, P-1600560 Lisbon, Portugal.
   [Fernandes, Carina] Hosp Forcas Armadas, Neurol Dept, P-1649020 Lisbon, Portugal.
   [Paiva, Teresa] Sleep Med Ctr CENC, P-1070068 Lisbon, Portugal.
   [Paiva, Teresa] Univ Nova Lisboa, Comprehens Hlth Res Ctr CHRC, Nova Med Sch, P-1169056 Lisbon, Portugal.
   [Moreira, Carlos Santos] Univ Lisbon, Fac Med, Med Clin 1, P-1649028 Lisbon, Portugal.
   [Caldeira, Daniel] Santa Maria Univ Hosp, Cardiol Dept, Hosp Santa Maria, Ctr Hosp Univ Lisboa Norte CHULN, P-1649028 Lisbon, Portugal.
   [Caldeira, Daniel] Univ Lisbon, Fac Med, Lab Clin Pharmacol & Therapeut, P-1649028 Lisbon, Portugal.
   [Caldeira, Daniel] Univ Lisbon, Ctr Cardiovasc Univ Lisboa CCUL, Fac Med, CAML, P-1649028 Lisbon, Portugal.
C3 Universidade de Lisboa; Universidade Nova de Lisboa; Universidade Nova
   de Lisboa; Universidade de Lisboa; Universidade de Lisboa; Hospital
   Santa Maria; Universidade de Lisboa; Universidade de Lisboa
RP Madeira, SG (corresponding author), Univ Lisbon, Fac Med, Inst Saude Ambiental ISAMB, P-1649026 Lisbon, Portugal.; Madeira, SG (corresponding author), Adm Reg Saude Lisboa & Vale Tejo, Family Hlth Unit Mactama, P-2745862 Lisbon, Portugal.
EM smadeira@medicina.ulisboa.pt; fernandes.carina@gmail.com;
   teresapaiva0@gmail.com; carlos.moreira@medicina.ulisboa.pt;
   dgcaldeira@hotmail.com
RI Fernandes, Carina/JRY-7239-2023; Caldeira, Daniel/AAJ-7974-2020
OI Gamboa Madeira, Sara/0000-0003-0764-571X; Caldeira,
   Daniel/0000-0002-2520-5673; Fernandes, Carina/0009-0001-6979-0384
FU Fundacao para a Ciencia e Tecnologia (FCT)/Fundo Social Europeu
   [PDE/BDE/127787/2016]; Fundação para a Ciência e a Tecnologia
   [PDE/BDE/127787/2016] Funding Source: FCT
FX This work was supported by the Ph.D. research Grant PDE/BDE/127787/2016
   from Fundacao para a Ciencia e Tecnologia (FCT)/Fundo Social Europeu.
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NR 62
TC 31
Z9 31
U1 0
U2 6
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD JUL
PY 2021
VL 18
IS 13
AR 6738
DI 10.3390/ijerph18136738
PG 19
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA TG2EE
UT WOS:000671221400001
PM 34201492
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Starnino, L
   Dupuis, G
   Busque, L
   Bourgoin, V
   Dubé, MP
   Busseuil, D
   D'Antono, B
AF Starnino, Louisia
   Dupuis, Gilles
   Busque, Lambert
   Bourgoin, Vincent
   Dube, Marie-Pierre
   Busseuil, David
   D'Antono, Bianca
TI The associations of hostility and defensiveness with telomere length are
   influenced by sex and health status
SO BIOLOGY OF SEX DIFFERENCES
LA English
DT Article
DE Telomere length; Hostility; Defensiveness; Cardiovascular disease; Sex
   and age
ID CORONARY-HEART-DISEASE; METABOLIC SYNDROME; CARDIOVASCULAR-DISEASE; AGE;
   RISK; METAANALYSIS; STRESS; WOMEN; SCALE; LIFE
AB Background Shorter telomere length (TL) may indicate premature cellular aging and increased risk for disease. While there is substantial evidence for shorter TL in individuals suffering from psychiatric disorders, data is scarce on maladaptive personality traits related to coronary artery disease (CAD). The purpose of this study was to evaluate the association of TL with hostility and defensiveness in individuals with CAD or other non-cardiovascular illnesses and whether associations were moderated by CAD status and sex. Methods One thousand thirty-six individuals (M-age = 65.40 +/- 6.73 years) with and without CAD completed the Marlowe-Crowne Social Desirability Scale and the Cook-Medley Hostility Scale. Relative TL was measured via quantitative polymerase chain reaction of total genomic DNA samples. Analyses involved hierarchical regressions on TL, performed separately for hostility and defensiveness, controlling for pertinent sociodemographic, behavioural, and medical risk factors. Separate analyses were performed on 25 healthy participants. Results A hostility by sex interaction emerged (beta = - .08, p = .006) in the patient groups, where greater hostility was associated with shorter TL in women only (p < .01). A Defensiveness by CAD status interaction (beta = - .06, p = .049) revealed longer TL in more defensive CAD patients only (p = .06). In healthy men, shorter TL was observed in those with greater defensiveness (beta = .52, p = .006) but lower hostility (beta = - .43, p = .049). Conclusion Hostility and defensiveness are differentially associated with TL as a function of sex and health status. The implication of these results for health remains to be determined, but propose an additional pathway through which the effect of maladaptive personality traits may contribute to CV and other disease.
C1 [Starnino, Louisia; Dube, Marie-Pierre; Busseuil, David; D'Antono, Bianca] Montreal Heart Inst, Res Ctr, 5000 Rue Belanger, Montreal, PQ H1T 1C8, Canada.
   [Starnino, Louisia; Dupuis, Gilles; D'Antono, Bianca] Univ Quebec Montreal, Dept Psychol, Montreal, PQ, Canada.
   [Busque, Lambert; Bourgoin, Vincent] Univ Montreal, Hop Maisonneuve Rosemont, Res Ctr, Hematol Div, Montreal, PQ, Canada.
   [D'Antono, Bianca] Univ Montreal, Dept Psychol, Pavillon Marie Victorin, Montreal, PQ, Canada.
C3 Universite de Montreal; University of Quebec; University of Quebec
   Montreal; Universite de Montreal; Universite de Montreal
RP D'Antono, B (corresponding author), Montreal Heart Inst, Res Ctr, 5000 Rue Belanger, Montreal, PQ H1T 1C8, Canada.; D'Antono, B (corresponding author), Univ Quebec Montreal, Dept Psychol, Montreal, PQ, Canada.; D'Antono, B (corresponding author), Univ Montreal, Dept Psychol, Pavillon Marie Victorin, Montreal, PQ, Canada.
EM bianca.d.antono@umontreal.ca
RI Dube, Marie-Pierre/B-9364-2008
OI Dube, Marie-Pierre/0000-0001-8442-4393
FU Canadian Institutes of Health Research (CIHR - MOP) [111015]; Montreal
   Heart Foundation; Fonds de la recherche en sante du Quebec (FRSQ);
   Academy of Finland (AKA) [111015] Funding Source: Academy of Finland
   (AKA)
FX This study was supported by grants awarded to Dr. D'Antono by the
   Canadian Institutes of Health Research (CIHR - MOP #111015) and the
   Montreal Heart Foundation. Louisia Starnino was supported by the
   Doctoral Training Award issued by the Fonds de la recherche en sante du
   Quebec (FRSQ). The funding sources had no involvement in this study.
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NR 76
TC 9
Z9 9
U1 0
U2 11
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 2042-6410
J9 BIOL SEX DIFFER
JI Biol. Sex Differ.
PD JAN 4
PY 2021
VL 12
IS 1
AR 2
DI 10.1186/s13293-020-00349-w
PG 13
WC Endocrinology & Metabolism; Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Genetics & Heredity
GA PQ9IP
UT WOS:000606855400002
PM 33397445
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Limanaqi, F
   Biagioni, F
   Busceti, CL
   Ryskalin, L
   Polzella, M
   Frati, A
   Fornai, F
AF Limanaqi, Fiona
   Biagioni, Francesca
   Busceti, Carla Letizia
   Ryskalin, Larisa
   Polzella, Maico
   Frati, Alessandro
   Fornai, Francesco
TI Phytochemicals Bridging Autophagy Induction and Alpha-Synuclein
   Degradation in Parkinsonism
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE curcumin; bacosides; ashwagandha; gallic; asiatic acids; resveratrol;
   catechins; synucleinopathy; cell-clearing pathways; metabolic syndrome
ID ROTENONE-INDUCED NEUROTOXICITY; PROTECTS DOPAMINERGIC-NEURONS;
   UBIQUITIN-PROTEASOME SYSTEM; INDUCED OXIDATIVE STRESS; SOMNIFERA ROOT
   EXTRACT; GREEN TEA POLYPHENOL; INDUCED MOUSE MODEL; BACOPA-MONNIERI;
   WITHANIA-SOMNIFERA; CENTELLA-ASIATICA
AB Among nutraceuticals, phytochemical-rich compounds represent a source of naturally-derived bioactive principles, which are extensively studied for potential beneficial effects in a variety of disorders ranging from cardiovascular and metabolic diseases to cancer and neurodegeneration. In the brain, phytochemicals produce a number of biological effects such as modulation of neurotransmitter activity, growth factor induction, antioxidant and anti-inflammatory activity, stem cell modulation/neurogenesis, regulation of mitochondrial homeostasis, and counteracting protein aggregation through modulation of protein-folding chaperones and the cell clearing systems autophagy and proteasome. In particular, the ability of phytochemicals in restoring proteostasis through autophagy induction took center stage in recent research on neurodegenerative disorders such as Parkinson's disease (PD). Indeed, autophagy dysfunctions and alpha-syn aggregation represent two interdependent downstream biochemical events, which concur in the parkinsonian brain, and which are targeted by phytochemicals administration. Therefore, in the present review we discuss evidence about the autophagy-based neuroprotective effects of specific phytochemical-rich plants in experimental parkinsonism, with a special focus on their ability to counteract alpha-synuclein aggregation and toxicity. Although further studies are needed to confirm the autophagy-based effects of some phytochemicals in parkinsonism, the evidence discussed here suggests that rescuing autophagy through natural compounds may play a role in preserving dopamine (DA) neuron integrity by counteracting the aggregation, toxicity, and prion-like spreading of alpha-syn, which remains a hallmark of PD.
C1 [Limanaqi, Fiona; Ryskalin, Larisa; Fornai, Francesco] Univ Pisa, Dept Translat Res & New Technol Med & Surg, Human Anat, Via Roma 55, I-56126 Pisa, PI, Italy.
   [Biagioni, Francesca; Busceti, Carla Letizia; Frati, Alessandro; Fornai, Francesco] IRCCS Neuromed, Via Atinense, I-86077 Pozzilli, Italy.
   [Polzella, Maico] Aliveda Labs, I-56042 Pisa, PI, Italy.
C3 University of Pisa; IRCCS Neuromed
RP Fornai, F (corresponding author), Univ Pisa, Dept Translat Res & New Technol Med & Surg, Human Anat, Via Roma 55, I-56126 Pisa, PI, Italy.; Fornai, F (corresponding author), IRCCS Neuromed, Via Atinense, I-86077 Pozzilli, Italy.
EM francesco.fornai@med.unipi.it
RI Polzella, Maico/ABF-8232-2020; FORNAI, FRANCESCO/AAA-5312-2019;
   Limanaqi, Fiona/AAP-7197-2020; Busceti, Carla/K-6485-2016; Ryskalin,
   Larisa/ISR-9458-2023; Frati, Alessandro/AAC-2204-2020; Biagioni,
   Francesca/G-7979-2011
OI RYSKALIN, LARISA/0000-0003-3150-1863; FRATI,
   ALESSANDRO/0000-0001-8062-614X; Biagioni, Francesca/0000-0003-3566-4889;
   FORNAI, FRANCESCO/0000-0002-3883-5084; Limanaqi,
   Fiona/0000-0003-0185-2099
FU Ministero della Salute (Ricerca Corrente 2019)
FX This work was funded by Ministero della Salute (Ricerca Corrente 2019).
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NR 276
TC 56
Z9 57
U1 1
U2 14
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD JUL 1
PY 2019
VL 20
IS 13
AR 3274
DI 10.3390/ijms20133274
PG 35
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA IL1EG
UT WOS:000477041100161
PM 31277285
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Günes, FE
   Bekiroglu, N
   Imeryuz, N
   Agirbasli, M
AF Gunes, F. Esra
   Bekiroglu, Nural
   Imeryuz, Nese
   Agirbasli, Mehmet
TI Awareness of cardiovascular risk factors among university students in
   Turkey
SO PRIMARY HEALTH CARE RESEARCH AND DEVELOPMENT
LA English
DT Article
DE awareness; cardiovascular diseases; healthy diet; risk factors; Turkey;
   young
ID CORONARY-HEART-DISEASE; METABOLIC SYNDROME; WOMENS AWARENESS; OBESITY;
   HYPERTENSION; PREVALENCE; MORTALITY; HEALTH; ATHEROSCLEROSIS;
   DISPARITIES
AB Aim: To determine the awareness of cardiovascular risk factors among university students in Turkey. Background: Cardiovascular disease (CVD) is the leading cause of death in developed countries. The use of tobacco products and unhealthy diet are prominent habits that increase the risk of CVD. Methods: Healthy university students (n = 2450) aged between 18 and 22 years in Istanbul filled out the questionnaire about the awareness of CVD risk factors and participated in this cross-sectional study. They were asked several questions with regard to the importance of CVD risk factors. Findings: The leading responses for men and women were, respectively, high cholesterol (58.3; 72.3%), stress (58.8; 71.8%), hypertension (50; 64.2%), smoking (53.1; 58.7%), obesity (46.8; 64.3%), diabetes (41.7; 52.7%), inactivity (43.3; 47.8%), and CVD in family history (31.8; 44.4%). Unhealthy diet (9.7; 15.3%), exposure to second-hand cigarette smoking (24.4; 34%), and poor socioeconomic status (22.6; 22.3%) were also considered to be important. The study also revealed that men disregard the risk factors more frequently. Another comparison between body mass index groups revealed that obese subjects gave significantly lower importance to cardiovascular risk factors. Conclusion: Observations indicate that awareness levels of CVD risk factors have to be improved among university students. It is emphasized that primary healthcare workers are very important in the screening of CVD risk factors in an opportunistic and systematic way and in providing consultancy on changing risky behaviors (diet, smoking, etc.). Therefore, it is of utmost importance that primary healthcare workers make interventions to reduce the risk level by determining the CVD risk.
C1 [Gunes, F. Esra; Bekiroglu, Nural] Marmara Univ, Fac Med, Dept Biostat, Istanbul, Turkey.
   [Imeryuz, Nese] Marmara Univ, Fac Med, Dept Gastroenterol, Istanbul, Turkey.
   [Agirbasli, Mehmet] Marmara Univ, Fac Med, Dept Cardiol, Istanbul, Turkey.
C3 Marmara University; Marmara University; Marmara University
RP Günes, FE (corresponding author), Marmara Univ, Saglik Bilimleri Fak, Beslenme & Diyetetik Bolumu, Basibuyuk Saglik Kampusu, TR-34000 Istanbul, Turkey.
EM fegunes@marmara.edu.tr
RI Gunes, Fatma/E-5188-2015; Imeryuz, Nese/MVT-9319-2025; Agirbasli,
   Mehmet/AFP-1794-2022
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NR 48
TC 11
Z9 12
U1 0
U2 4
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 1463-4236
EI 1477-1128
J9 PRIM HEALTH CARE RES
JI Prim. Health Care Res. Dev.
PY 2019
VL 20
AR e127
DI 10.1017/S146342361900063X
PG 10
WC Primary Health Care
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA IV8ME
UT WOS:000484518800001
PM 31477189
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Hatamipour, M
   Ramezani, M
   Tabassi, SAS
   Johnston, TP
   Ramezani, M
   Sahebkar, A
AF Hatamipour, Mahdi
   Ramezani, Mahin
   Tabassi, Sayyed Abolghasem Sajadi
   Johnston, Thomas P.
   Ramezani, Mahnaz
   Sahebkar, Amirhosein
TI Demethoxycurcumin: A naturally occurring curcumin analogue with
   antitumor properties
SO JOURNAL OF CELLULAR PHYSIOLOGY
LA English
DT Review
DE cancer; curcuminoids; demethoxycurcumin; metastasis
ID CANCER-CELL-PROLIFERATION; FATTY LIVER-DISEASE; NF-KAPPA-B; CHRONIC
   PULMONARY COMPLICATIONS; SYSTEMIC OXIDATIVE STRESS; PHOTODYNAMIC
   THERAPY; DOWN-REGULATION; PIPERINE COMBINATION; SIGNALING PATHWAYS;
   METABOLIC SYNDROME
AB The eradication of cancer in a patient remains an elusive challenge despite advances in early detection and diagnosis, chemo- and immunotherapy, pinpoint radiation treatments, and expert surgical intervention. Although significant gains have been made in our understanding of cancer cell biology, a definite cure for most cancers does not exist at present. Thus, it is not surprising that the research and medical communities continue to explore the importance and therapeutic potential of natural products in their multimodality cancer treatment approach. Curcuminoids found in turmeric are one such class of natural products that have been extensively investigated for their potential to halt the progression of cancer cell proliferation and, more important, to stop metastasis from occurring. In this review, we examine one curcuminoid (demethoxycurcumin[DMC]) largely because of its increased stability and better aqueous solubility at physiological pH, unlike the more well-known curcuminoid (curcumin), which is largely unabsorbed after oral ingestion. The present review will focus on the signaling pathways that DMC utilizes to modulate the growth, invasion, and metastasis of cancer cells in an effort to provide enhanced mechanistic insight into DMC's action as it pertains to brain, ovarian, breast, lung, skin, and prostate cancer. Additionally, this review will attempt to provide an overview of DMC's mechanism of action by modulating apoptosis, cell cycle, angiogenesis, metastasis, and chemosensitivity. Lastly, it is hoped that increased understanding will be gained concerning DMC's interactive role with microRNA-551a, 5 adenosine monophosphate-activated protein kinase, nuclear factor-B, Wnt inhibitory factor-1, and heat shock protein 70 to affect the progression of cancer.
C1 [Hatamipour, Mahdi; Ramezani, Mahin] Mashhad Univ Med Sci, Nanotechnol Res Ctr, Mashhad, Iran.
   [Tabassi, Sayyed Abolghasem Sajadi] Mashhad Univ Med Sci, Pharmacol Res Ctr Med Plants, Mashhad, Iran.
   [Johnston, Thomas P.] Univ Missouri, Div Pharmaceut Sci, Kansas City, MO 64110 USA.
   [Ramezani, Mahnaz] Rafsanjan Univ Med Sci, Immunol Infect Dis Res Ctr, Rafsanjan, Iran.
   [Sahebkar, Amirhosein] Mashhad Univ Med Sci, Neurogen Inflammat Res Ctr, Mashhad, Iran.
   [Sahebkar, Amirhosein] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Biotechnol Res Ctr, Mashhad, Iran.
   [Sahebkar, Amirhosein] Mashhad Univ Med Sci, Sch Pharm, Mashhad, Iran.
C3 Mashhad University of Medical Sciences; Mashhad University of Medical
   Sciences; University of Missouri System; University of Missouri Kansas
   City; Mashhad University of Medical Sciences; Mashhad University of
   Medical Sciences; Mashhad University of Medical Sciences
RP Sahebkar, A (corresponding author), Mashhad Univ Med Sci, Sch Med, Dept Med Biotechnol, POB 91779-48564, Mashhad, Iran.
EM sahebkara@mums.ac.ir
RI Sahebkar, Amirhossein/B-5124-2018; ramezani, mahnaz/AAB-7622-2022
OI Ramezani, Mahnaz/0000-0002-4483-1821
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NR 132
TC 32
Z9 37
U1 0
U2 50
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0021-9541
EI 1097-4652
J9 J CELL PHYSIOL
JI J. Cell. Physiol.
PD DEC
PY 2018
VL 233
IS 12
BP 9247
EP 9260
DI 10.1002/jcp.27029
PG 14
WC Cell Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Physiology
GA GW7LE
UT WOS:000447148600019
PM 30076727
DA 2025-06-11
ER

PT J
AU Xin, Y
   Zhang, HY
   Jia, ZT
   Ding, XQ
   Sun, Y
   Wang, Q
   Xu, T
AF Xin, Ying
   Zhang, Haiyan
   Jia, Zhaotong
   Ding, Xiaoqian
   Sun, Yong
   Wang, Qiang
   Xu, Tao
TI Resveratrol improves uric acid-induced pancreatic β-cells injury and
   dysfunction through regulation of miR-126
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Article
DE Resveratrol; Uric acid; microRNA-126; KLF2; PI3K/AKT
ID TYPE-2 DIABETES-MELLITUS; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   OXIDATIVE STRESS; PI3K/AKT; RATS; MICE; ASSOCIATION; ACTIVATION;
   APOPTOSIS
AB Resveratrol (RSV) has been reported to exert anti-inflammatory, anti-oxidant and anti-cancer effects both in vivo and in vitro, and is widely used to treat various diseases. However, the effect of RSV on type 2 diabetes (T2D) is still unclear. The present study aimed to explore the effect of RSV on UA-induced cell injury and dysfunction in pancreatic beta-cells. The mouse insulinoma cell line Min6 was treated with 5 mg/dl UA and different concentrations of RSV. Then, cell viability, apoptosis, apoptosis-associated factors, iNOS expression and insulin secretion were examined by CCK-8, flow cytometry, western blot, qRT-PCR and glucose-stimulated insulin secretion (GSIS), respectively. MiR-126 inhibitor and sh-KLF2 were transfected into Min6 cells to alter the expression levels and to reveal the regulatory relationship with RSV. PI3K/AKT signal pathway was analyzed by western blot to uncover the underling mechanism. UA treatment suppressed cell viability, promoted apoptosis, enhanced iNOS expression and decreased insulin secretion in Min6 cells. RSV significantly alleviated UA-induced injury and dysfunction in Min6 cells. The expression level of miR-126 was up-regulated by RSV, and suppression of miR-126 abolished the protective effect of RSV on UA-injured Min6 cells. Additionally, RSV up-regulated KLF2 expression, the promoting effect of RSV on miR-126 expression was reversed by KLF2 silence. Besides, RSV activated PI3K/AKT signal pathway by up-regulation of miR-126 in UA-injured Min6 cells. These data indicated that RSV could protect Min6 cells against UA-induced injury and dysfunction by regulation of miR-126 and activation of PI3K/AKT signal pathway.
C1 [Xin, Ying; Jia, Zhaotong] Qingdao Univ, Affiliated Hosp, Dept Endocrine & Metab Dis, Qingdao 266003, Peoples R China.
   [Zhang, Haiyan] Qingdao Univ, Affiliated Hosp, Dept Endoscopy Ctr, Qingdao 266003, Peoples R China.
   [Ding, Xiaoqian; Sun, Yong; Wang, Qiang; Xu, Tao] Qingdao Univ, Affiliated Hosp, Dept Resp Med, 16 Jiangsu Rd, Qingdao 266003, Peoples R China.
C3 Qingdao University; Qingdao University; Qingdao University
RP Xu, T (corresponding author), Qingdao Univ, Affiliated Hosp, Dept Resp Med, 16 Jiangsu Rd, Qingdao 266003, Peoples R China.
EM taoxu567@sina.com
RI Zhang, Haiyan/IUN-2627-2023; tao, xu/E-7171-2019
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NR 40
TC 26
Z9 28
U1 0
U2 19
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD JUN
PY 2018
VL 102
BP 1120
EP 1126
DI 10.1016/j.biopha.2018.03.172
PG 7
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA GG3HV
UT WOS:000432583800127
PM 29710530
DA 2025-06-11
ER

PT J
AU Liu, ZJ
   Gan, L
   Luo, D
   Sun, C
AF Liu, Zhenjiang
   Gan, Lu
   Luo, Dan
   Sun, Chao
TI Melatonin promotes circadian rhythm-induced proliferation through
   Clock/histone deacetylase 3/c-Myc interaction in mouse adipose tissue
SO JOURNAL OF PINEAL RESEARCH
LA English
DT Article
DE adipose; circadian clock; c-Myc; melatonin; proliferation
ID MESENCHYMAL STEM-CELLS; OXIDATIVE STRESS; CANCER CELLS; IN-VITRO;
   TRANSCRIPTIONAL ACTIVITY; METABOLIC SYNDROME; GENE-EXPRESSION; CLOCK;
   OBESITY; SIRT1
AB Melatonin is synthesized in the pineal gland and controls circadian rhythm of peripheral adipose tissue, resulting in changes in body weight. Although core regulatory components of clock rhythmicity have been defined, insight into the mechanisms of circadian rhythm-mediated proliferation in adipose tissue is still limited. Here, we showed that melatonin (20 mg/kg/d) promoted circadian and proliferation processes in white adipose tissue. The circadian amplitudes of brain and muscle aryl hydrocarbon receptor nuclear translocator-like 1 (Bmal1, P<.05) and circadian locomotor output cycles kaput (Clock, P<.05), period 2 (Per2, P<.05), cyclin E (P<.05), and c-Myc (P<.05) were directly increased by melatonin in adipose tissue. Melatonin also promoted cell cycle and increased cell numbers (P<.05), which was correlated with the Clock expression (P<.05). Further analysis demonstrated that Clock bound to the E-box elements in the promoter region of c-Myc and then directly stimulated c-Myc transcription. Moreover, Clock physically interacted with histone deacetylase 3 (HDAC3) and formed a complex with c-Myc to promote adipocyte proliferation. Melatonin also attenuated circadian disruption and promoted adipocyte proliferation in chronic jet-lagged mice and obese mice. Thus, our study found that melatonin promoted adipocyte proliferation by forming a Clock/HDAC3/c-Myc complex and subsequently driving the circadian amplitudes of proliferation genes. Our data reveal a novel mechanism that links circadian rhythm to cell proliferation in adipose tissue. These findings also identify a new potential means for melatonin to prevent and treat sleep deprivation-caused obesity.
C1 [Liu, Zhenjiang; Gan, Lu; Luo, Dan; Sun, Chao] Northwest A&F Univ, Coll Anim Sci & Technol, Yangling, Shaanxi, Peoples R China.
C3 Northwest A&F University - China
RP Sun, C (corresponding author), Northwest A&F Univ, Coll Anim Sci & Technol, Yangling, Shaanxi, Peoples R China.
EM sunchao2775@163.com
RI Gan, Lu/JXX-1314-2024; Luo, Dan/HZM-2412-2023; Liu,
   Zhenjiang/AAL-3343-2021
OI Sun, Chao/0000-0001-7222-4028
FU National Natural Science Foundation of China [31572365]; Major National
   Scientific Research Projects [2015CB943102]
FX National Natural Science Foundation of China, Grant/Award Number:
   31572365; Major National Scientific Research Projects, Grant/Award
   Number: 2015CB943102
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NR 68
TC 72
Z9 72
U1 4
U2 58
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0742-3098
EI 1600-079X
J9 J PINEAL RES
JI J. Pineal Res.
PD MAY
PY 2017
VL 62
IS 4
AR e12383
DI 10.1111/jpi.12383
PG 14
WC Endocrinology & Metabolism; Neurosciences; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Physiology
GA EQ9FV
UT WOS:000398390900001
PM 27987529
DA 2025-06-11
ER

PT J
AU Wang, J
   Wu, XF
   Li, YR
   Han, X
   Hu, H
   Wang, F
   Yu, CZ
   Li, XL
   Yang, K
   Yuan, J
   Yao, P
   Miao, XP
   Wei, S
   Wang, YJ
   Chen, WH
   Liang, Y
   Guo, H
   Yang, HD
   Wu, TC
   Zhang, XM
   He, MA
AF Wang, Jing
   Wu, Xiaofen
   Li, Yaru
   Han, Xu
   Hu, Hua
   Wang, Fei
   Yu, Caizheng
   Li, Xiulou
   Yang, Kun
   Yuan, Jing
   Yao, Ping
   Miao, Xiaoping
   Wei, Sheng
   Wang, Youjie
   Chen, Weihong
   Liang, Yuan
   Guo, Huan
   Yang, Handong
   Wu, Tangchun
   Zhang, Xiaomin
   He, Meian
TI Serum bilirubin concentrations and incident coronary heart disease risk
   among patients with type 2 diabetes: the Dongfeng-Tongji cohort
SO ACTA DIABETOLOGICA
LA English
DT Article
DE Bilirubin; Cohort; Type 2 diabetes; Coronary heart disease; Chinese
ID LOW-DENSITY-LIPOPROTEIN; UGT1A1-ASTERISK-28 ALLELE; VASCULAR
   COMPLICATIONS; ALCOHOL-CONSUMPTION; METABOLIC SYNDROME; ASSOCIATION;
   ANTIOXIDANTS; DURATION; STRESS
AB Elevated serum bilirubin levels are associated with decreased coronary heart disease (CHD) risk in cross-sectional studies among diabetic patients, but prospective evidence is limited. We investigated the relationship of serum bilirubin levels with incident CHD risk among type 2 diabetes patients.
   In a prospective study of 2918 type 2 diabetes embedded in the Dongfeng-Tongji cohort, serum total bilirubin (TBil), direct bilirubin (DBil), and indirect bilirubin (IBil) were measured at baseline. Cox proportional hazards models were used to examine the association between serum bilirubin levels and CHD risk.
   A total of 440 CHD cases were identified during 12,017 person-years of follow-up. Compared with extreme quartiles, the adjusted hazard ratio and 95% confidence interval of incident CHD were 0.74 (0.56-0.99) with P trend = 0.08 in IBil, while in TBil and DBil, the bilirubin-CHD associations were not significant. Moreover, serum TBil and IBil levels were interacted with drinking status on the risk of incident CHD (P interaction = 0.021 and 0.037, respectively), and the associations were evident in ever drinkers. In drinkers, when serum TBil or IBil concentrations increased 1 mu mol/L, the CHD risk both decreased 6% (95% CIs 0.89-0.99 and 0.87-1.00, respectively).
   Serum IBil levels were marginally related to decreased incident CHD risk among type 2 diabetes. Drinking could potentially enhance the associations of serum TBil and DBil levels with incident CHD risk.
C1 [Wang, Jing; Li, Yaru; Han, Xu; Hu, Hua; Wang, Fei; Yu, Caizheng; Yuan, Jing; Yao, Ping; Wang, Youjie; Chen, Weihong; Liang, Yuan; Guo, Huan; Wu, Tangchun; Zhang, Xiaomin; He, Meian] Huazhong Univ Sci & Technol, Sch Publ Hlth, Dept Occupat & Environm Hlth, Tongji Med Coll, 13 Hangkong Rd, Wuhan 430030, Hubei, Peoples R China.
   [Wang, Jing; Li, Yaru; Han, Xu; Hu, Hua; Wang, Fei; Yu, Caizheng; Yuan, Jing; Yao, Ping; Wang, Youjie; Chen, Weihong; Liang, Yuan; Guo, Huan; Wu, Tangchun; Zhang, Xiaomin; He, Meian] Huazhong Univ Sci & Technol, Sch Publ Hlth, State Key Lab Environm Hlth Incubating, Tongji Med Coll, 13 Hangkong Rd, Wuhan 430030, Hubei, Peoples R China.
   [Wang, Jing] Hubei Univ Med, Sch Publ Hlth & Management, Dept Prevent Med, Shiyan, Hubei, Peoples R China.
   [Wu, Xiaofen] Huazhong Univ Sci & Technol, Tongji Hosp, Dept Gerontol, Tongji Med Coll, Wuhan, Peoples R China.
   [Li, Xiulou; Yang, Kun; Yang, Handong] Dongfeng Motor Corp, Dongfeng Cent Hosp, Shiyan, Hubei, Peoples R China.
   [Li, Xiulou; Yang, Kun; Yang, Handong] Hubei Univ Med, Shiyan, Hubei, Peoples R China.
   [Miao, Xiaoping; Wei, Sheng] Huazhong Univ Sci & Technol, Sch Publ Hlth, Dept Epidemiol & Biostatist, Tongji Med Coll, Wuhan, Peoples R China.
C3 Huazhong University of Science & Technology; Huazhong University of
   Science & Technology; Hubei University of Medicine; Huazhong University
   of Science & Technology; Dongfeng Motor; Hubei University of Medicine;
   Huazhong University of Science & Technology
RP He, MA (corresponding author), Huazhong Univ Sci & Technol, Sch Publ Hlth, Dept Occupat & Environm Hlth, Tongji Med Coll, 13 Hangkong Rd, Wuhan 430030, Hubei, Peoples R China.; He, MA (corresponding author), Huazhong Univ Sci & Technol, Sch Publ Hlth, State Key Lab Environm Hlth Incubating, Tongji Med Coll, 13 Hangkong Rd, Wuhan 430030, Hubei, Peoples R China.
EM hemeian@hotmail.com
RI j, w/HGD-7409-2022; Zhang, Xiaomin/F-3206-2018; li, yan/GXH-7943-2022;
   Chen, Weihong/D-2177-2011; wei, sheng/E-9746-2012; yu, ye/KVB-7532-2024;
   miao, xiaoping/C-4336-2011
OI Wang, Jing/0000-0003-4869-7719; miao, xiaoping/0000-0002-6818-9722
FU National Natural Science Foundation [NSFC-81473051, 81522040,
   NSFC-81230069, NSFC-71273083]; Program for the New Century Excellent
   Talents in University [NCET-11-0169]; Natural Science Foundation of
   Hubei Provincial Department of Education [D20162105]
FX This work was supported by the grant from the National Natural Science
   Foundation (Grant NSFC-81473051 and 81522040) and the Program for the
   New Century Excellent Talents in University (NCET-11-0169) for Meian He,
   the National Natural Science Foundation (Grant NSFC-81230069) for
   Tangchun Wu, the National Natural Science Foundation (Grant
   NSFC-71273083), and the Natural Science Foundation of Hubei Provincial
   Department of Education (D20162105) for Jing Wang.
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NR 40
TC 13
Z9 15
U1 1
U2 14
PU SPRINGER-VERLAG ITALIA SRL
PI MILAN
PA VIA DECEMBRIO, 28, MILAN, 20137, ITALY
SN 0940-5429
EI 1432-5233
J9 ACTA DIABETOL
JI Acta Diabetol.
PD MAR
PY 2017
VL 54
IS 3
BP 257
EP 264
DI 10.1007/s00592-016-0946-x
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA EM2UA
UT WOS:000395170000005
PM 27933515
DA 2025-06-11
ER

PT J
AU Gasparini, SJ
   Weber, MC
   Henneicke, H
   Kim, S
   Zhou, H
   Seibel, MJ
AF Gasparini, Sylvia J.
   Weber, Marie-Christin
   Henneicke, Holger
   Kim, Sarah
   Zhou, Hong
   Seibel, Markus J.
TI Continuous corticosterone delivery via the drinking water or pellet
   implantation: A comparative study in mice
SO STEROIDS
LA English
DT Article
DE Hypercortisolism; Corticosterone delivery; Glucocorticoid-induced
   dysmetabolism; Insulin-resistance; Sarcopenia; Osteoporosis
ID SKELETAL-MUSCLE; METABOLIC SYNDROME; GLUCOCORTICOIDS; MOUSE; RAT; MODEL
AB In order to investigate the effects of glucocorticoid excess in rodent models, reliable methods of continuous glucocorticoid delivery are essential. The current study compares two methods of corticosterone (CS) delivery in regards to their ability to induce typical adverse outcomes such as fat accrual, insulin resistance, sarcopenia and bone loss.
   Eight-week-old mice received CS for 4 weeks either via the drinking water (25-100 mu tg CS/mL) or through weekly surgical implantation of slow release pellets containing 1.5 mg CS. Both methods induced abnormal fat mass accrual, inhibited lean mass accretion and bone expansion, suppressed serum osteocalcin levels and induced severe insulin resistance. There was a clear dose dependant relationship between the CS concentrations in the drinking water and the severity of the phenotype, with a concentration of 50 mu g CS/mL drinking water most closely matching the metabolic changes induced by weekly pellet implantations. In contrast to pellets, however, delivery of CS via the drinking water resulted in a consistent diurnal exposure pattern, closely mimicking the kinetics of clinical glucocorticoid therapy. In addition, the method is safe, inexpensive, easily adjustable, non-invasive and avoids operative stress to the animals.
   Our data demonstrate that delivery of CS via the drinking water has advantages over weekly implantations of slow-release pellets. A dose of 50 mu g CS/mL drinking water is appropriate for the investigation of chronic glucocorticoid excess in mice. Crown Copyright (C) 2016 Published by Elsevier Inc. All rights reserved.
C1 [Gasparini, Sylvia J.; Weber, Marie-Christin; Henneicke, Holger; Kim, Sarah; Zhou, Hong; Seibel, Markus J.] Univ Sydney, ANZAC Res Inst, Bone Res Program, Sydney, NSW, Australia.
   [Weber, Marie-Christin] Charite, Dept Rheumatol & Clin Immunol, Berlin, Germany.
   [Henneicke, Holger] Tech Univ Dresden, DFG Ctr Regenerat Therapies, Dresden, Germany.
   [Seibel, Markus J.] Univ Sydney, Concord Med Sch, Sydney, NSW, Australia.
C3 University of Sydney; ANZAC Research Institute; Berlin Institute of
   Health; Free University of Berlin; Humboldt University of Berlin;
   Charite Universitatsmedizin Berlin; German Research Foundation (DFG);
   Technische Universitat Dresden; University of Sydney
RP Gasparini, SJ; Seibel, MJ (corresponding author), ANZAC Res Inst, Bone Res Program, Sydney, NSW 2139, Australia.
EM sylvia.gasparini@sydney.edu.au; markus.sei-bel@sydney.edu.au
RI Henneicke, Holger/H-3383-2016
OI Zhou, Hong/0000-0001-5899-9660; Henneicke, Holger/0000-0003-1746-9369;
   Gasparini, Sylvia/0000-0002-3612-6428; Seibel, Markus
   J/0000-0002-2701-378X; Kim, Sarah/0000-0002-9350-5176
FU NHMRC project [APP1086100]; Australian government for Australian
   Postgraduate Award; Humboldt University/Charite University Medicine,
   Berlin
FX This study was supported by NH&MRC project grant APP1086100 to MJS, the
   Australian government for Australian Postgraduate Award (SJG, SK), an
   International Postgraduate Research Scholarship (HH) and a research
   stipend from Humboldt University/Charite University Medicine, Berlin
   (MCW).
CR Bodine SC, 2015, ADV EXP MED BIOL, V872, P145, DOI 10.1007/978-1-4939-2895-8_7
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NR 19
TC 36
Z9 38
U1 0
U2 16
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0039-128X
EI 1878-5867
J9 STEROIDS
JI Steroids
PD DEC
PY 2016
VL 116
BP 76
EP 82
DI 10.1016/j.steroids.2016.10.008
PG 7
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA EF7GH
UT WOS:000390497600011
PM 27815034
DA 2025-06-11
ER

PT J
AU Pongkan, W
   Pintana, H
   Jaiwongkam, T
   Kredphoo, S
   Sivasinprasasn, S
   Chattipakorn, SC
   Chattipakorn, N
AF Pongkan, Wanpitak
   Pintana, Hiranya
   Jaiwongkam, Thidarat
   Kredphoo, Sasiwan
   Sivasinprasasn, Sivaporn
   Chattipakorn, Siriporn C.
   Chattipakorn, Nipon
TI Vildagliptin reduces cardiac ischemic-reperfusion injury in obese
   orchiectomized rats
SO JOURNAL OF ENDOCRINOLOGY
LA English
DT Article
DE obese testosterone deprivation; dipeptidyl peptidase-4 inhibitors;
   ischemia-reperfusion; cardiac mitochondrial function
ID MYOCARDIAL-INFARCTION; OXIDATIVE STRESS; REPLACEMENT THERAPY;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; BODY-COMPOSITION; HYPOGONADAL
   MEN; HEART-FAILURE; TESTOSTERONE; DISEASE
AB Obesity and testosterone deprivation are associated with coronary artery disease. Testosterone and vildagliptin (dipeptidyl peptidase-4 inhibitors) exert cardioprotection during ischemic-reperfusion (I/R) injury. However, the effect of these drugs on I/R heart in a testosterone-deprived, obese, insulin-resistant model is unclear. This study investigated the effects of testosterone and vildagliptin on cardiac function, arrhythmias and the infarct size in I/R heart of testosterone-deprived rats with obese insulin resistance. Orchiectomized (O) or sham operated (S) male Wistar rats were divided into 2 groups to receive normal diet (ND) or high-fat diet (HFD) for 12 weeks. Orchiectomized rats in each diet were divided to receive testosterone (2 mg/kg), vildagliptin (3 mg/kg) or the vehicle daily for 4 weeks. Then, I/R was performed by a 30-min left anterior descending coronary artery ligation, followed by a 120-min reperfusion. LV function, arrhythmia scores, infarct size and cardiac mitochondrial function were determined. HFD groups developed insulin resistance at week 12. At week 16, cardiac function was impaired in NDO, HFO and HFS rats, but was restored in all testosterone-and vildagliptin-treated rats. During I/R injury, arrhythmia scores, infarct size and cardiac mitochondrial dysfunction were prominently increased in NDO, HFO and HFS rats, compared with those in NDS rats. Treatment with either testosterone or vildagliptin similarly attenuated these impairments during I/R injury. These finding suggest that both testosterone replacement and vildagliptin share similar efficacy for cardioprotection during I/R injury by decreasing the infarct size and attenuating cardiac mitochondrial dysfunction caused by I/R injury in testosterone-deprived rats with obese insulin resistance.
C1 [Pongkan, Wanpitak; Pintana, Hiranya; Jaiwongkam, Thidarat; Kredphoo, Sasiwan; Sivasinprasasn, Sivaporn; Chattipakorn, Siriporn C.; Chattipakorn, Nipon] Chiang Mai Univ, Fac Med, Cardiac Electrophysiol Res & Training Ctr, Chiang Mai, Thailand.
   [Pongkan, Wanpitak; Pintana, Hiranya; Jaiwongkam, Thidarat; Kredphoo, Sasiwan; Sivasinprasasn, Sivaporn; Chattipakorn, Siriporn C.; Chattipakorn, Nipon] Chiang Mai Univ, Fac Med, Dept Physiol, Cardiac Electrophysiol Unit, Chiang Mai, Thailand.
   [Pongkan, Wanpitak; Jaiwongkam, Thidarat; Kredphoo, Sasiwan; Sivasinprasasn, Sivaporn; Chattipakorn, Nipon] Chiang Mai Univ, Fac Med, Ctr Excellence Cardiac Electrophysiol Res, Chiang Mai, Thailand.
   [Chattipakorn, Siriporn C.] Chiang Mai Univ, Dept Oral Biol & Diagnost Sci, Fac Dent, Chiang Mai, Thailand.
C3 Chiang Mai University; Chiang Mai University; Chiang Mai University;
   Chiang Mai University
RP Chattipakorn, N (corresponding author), Chiang Mai Univ, Fac Med, Cardiac Electrophysiol Res & Training Ctr, Chiang Mai, Thailand.; Chattipakorn, N (corresponding author), Chiang Mai Univ, Fac Med, Dept Physiol, Cardiac Electrophysiol Unit, Chiang Mai, Thailand.; Chattipakorn, N (corresponding author), Chiang Mai Univ, Fac Med, Ctr Excellence Cardiac Electrophysiol Res, Chiang Mai, Thailand.
EM nchattip@gmail.com
RI Chattipakorn, Nipon/AAJ-4049-2021; Pongkan, Wanpitak/N-8420-2018
OI Chattipakorn, Siriporn/0000-0003-1677-7052; Chattipakorn,
   Nipon/0000-0003-3026-718X; Pongkan, Wanpitak/0000-0001-6788-7740
FU NSTDA Research Chair Grant from the National Science and Technology
   Development Agency Thailand; Thailand Research Fund [BRG5780016]; Royal
   Golden Jubilee PhD Program; National Research Council Thailand; Chiang
   Mai University Center of Excellence Center Award
FX This work was supported by the NSTDA Research Chair Grant from the
   National Science and Technology Development Agency Thailand (N C) and
   grants from the Thailand Research Fund BRG5780016 (S C), the Royal
   Golden Jubilee PhD Program (N C and W P), the National Research Council
   Thailand (N C) and the Chiang Mai University Center of Excellence Center
   Award (N C).
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NR 54
TC 19
Z9 19
U1 0
U2 6
PU BIOSCIENTIFICA LTD
PI BRISTOL
PA EURO HOUSE, 22 APEX COURT WOODLANDS, BRADLEY STOKE, BRISTOL BS32 4JT,
   ENGLAND
SN 0022-0795
EI 1479-6805
J9 J ENDOCRINOL
JI J. Endocrinol.
PD OCT
PY 2016
VL 231
IS 1
BP 81
EP 95
DI 10.1530/JOE-16-0232
PG 15
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA DZ6CY
UT WOS:000385950400010
PM 27543302
OA Bronze
DA 2025-06-11
ER

PT J
AU Rajapakse, NW
   Karim, F
   Straznicky, NE
   Fernandez, S
   Evans, RG
   Head, GA
   Kaye, DM
AF Rajapakse, N. W.
   Karim, F.
   Straznicky, N. E.
   Fernandez, S.
   Evans, R. G.
   Head, G. A.
   Kaye, D. M.
TI Augmented endothelial-specific L-arginine transport prevents
   obesity-induced hypertension
SO ACTA PHYSIOLOGICA
LA English
DT Article
DE hypertension; kidney; L-arginine transport; nitric oxide; obesity
ID NITRIC-OXIDE SYNTHASE; ANGIOTENSIN-CONVERTING ENZYME; BLOOD-PRESSURE;
   OXIDATIVE STRESS; METABOLIC SYNDROME; ARTERIAL-PRESSURE; KIDNEY;
   BIOAVAILABILITY; INHIBITION; RESPONSES
AB AimHypertension is a major clinical complication of obesity. Our previous studies show that abnormal uptake of the nitric oxide precursor L-arginine, via the cationic amino acid transporter-1 (CAT1), contributes to endothelial dysfunction in cardiovascular disease. In this study, we tested the hypothesis that abnormal L-arginine transport may be a key mediator of obesity-induced hypertension.
   MethodsMean arterial pressure (MAP) was monitored by telemetry in conscious wild-type (WT; n=13) mice, and transgenic mice with endothelial-specific overexpression of CAT1 (CAT+; n=14) fed a normal or a high fat diet for 20weeks. Renal angiotensin II (Ang II), CAT1 mRNA and plasma nitrate/nitrite levels were then quantified. In conjunction, plasma nitrate/nitrite levels were assessed in obese normotensive (n=15) and obese hypertensive subjects (n=15).
   ResultsBoth genotypes of mice developed obesity when fed a high fat diet (P0.002). Fat fed WT mice had 13% greater MAP and 78% greater renal Ang II content, 42% lesser renal CAT1 mRNA levels and 42% lesser plasma nitrate/nitrite levels, than WT mice fed a normal fat diet (P0.02). In contrast, none of these variables were significantly altered by high fat feeding in CAT+ mice (P0.36). Plasma nitrate/nitrite levels were 17% less in obese hypertensives compared with obese normotensives (P=0.02).
   ConclusionCollectively, these data indicate that obesity-induced down-regulation of CAT1 expression and subsequent reduced bioavailability of nitric oxide may contribute to the development of obesity-induced hypertension.
C1 [Rajapakse, N. W.; Karim, F.; Straznicky, N. E.; Fernandez, S.; Head, G. A.; Kaye, D. M.] Baker IDI Heart & Diabet Inst, Melbourne, Vic, Australia.
   [Evans, R. G.] Monash Univ, Dept Physiol, Melbourne, Vic 3168, Australia.
C3 Baker Heart and Diabetes Institute; Monash University
RP Rajapakse, NW (corresponding author), Baker IDI Heart & Diabet Inst, Heart Failure Res Grp, 75 Commercial Rd, Melbourne, Vic 3004, Australia.
EM niwanthi.rajapakse@bakeridi.edu.au
RI Fernandez, Sandra/A-8031-2010; Straznicky, Nora/E-7484-2010; Evans,
   Roger/N-8580-2019; Kaye, David/AAF-1202-2021; Head, Geoffrey/B-2177-2010
OI Head, Geoffrey/0000-0002-7623-137X; Kaye, David/0000-0003-4058-0372;
   Rajapakse, Niwanthi/0000-0001-9777-1087; Evans,
   Roger/0000-0002-9241-0757
FU National Health and Medical Research Council, Australia [1036352];
   National Heart Foundation, Australia [PF09M4668]; CASS Medicinal Project
   Grant; Victorian Government
FX We thank Ms. Ouda Khammy for performing PCR and measurements of plasma
   nitrate/nitrite; Ms. Ava Mishra and Prof. James Pitt of Royal Children's
   Hospital, Melbourne, for quantifying plasma L-arginine levels; and Ms.
   Mariee Grima for analysis of diet records. This work was funded by the
   National Health and Medical Research Council, Australia (Program grant
   ID 1036352 to DK), National Heart Foundation, Australia (PF09M4668 to
   NR) and by a CASS Medicinal Project Grant to NR, and also in part by the
   Victorian Government's Operational Infrastructure Support Programme.
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NR 32
TC 28
Z9 30
U1 0
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1748-1708
EI 1748-1716
J9 ACTA PHYSIOL
JI Acta Physiol.
PD SEP
PY 2014
VL 212
IS 1
BP 39
EP 48
DI 10.1111/apha.12344
PG 10
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA AP0QW
UT WOS:000341768700009
PM 25041756
DA 2025-06-11
ER

PT J
AU Chuengsamarn, S
   Rattanamongkolgul, S
   Jirawatnotai, S
AF Chuengsamarn, Somlak
   Rattanamongkolgul, Suthee
   Jirawatnotai, Siwanon
TI Association between serum uric acid level and microalbuminuria to
   chronic vascular complications in Thai patients with type 2 diabetes
SO JOURNAL OF DIABETES AND ITS COMPLICATIONS
LA English
DT Article
DE Uric acid; Microalbuminuria; Chronic vascular complications; Type 2
   diabetes
ID URINARY ALBUMIN EXCRETION; ENDOTHELIAL DYSFUNCTION; METABOLIC SYNDROME;
   CARDIOVASCULAR RISK; INSULIN-RESISTANCE; OXIDATIVE STRESS; INFLAMMATION;
   ATHEROSCLEROSIS; DEFINITION; PREDICTION
AB Aims: To investigate an association between serum uric acid/microalbuminuria and chronic micro/macro-vascular complications in type 2 diabetic patients.
   Methods: This cross-sectional study enrolled 608 patients with type 2 diabetes. All subjects were examined and basic information on health of the subjects was recorded for inclusion criteria. Several chemical parameters (fasting plasma glucose, triglyceride, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, uric acid, and microalbuminuria), and related chronic vascular complications were measured and recorded in data forms.
   Results: Logistic regressions were used to analyse odds ratios between uric acid/microalbuminuria levels and several chronic vascular complications. Prevalence of chronic vascular complications in T2DM patients, namely coronary arterial disease, cerebrovascular disease, diabetic nephropathy, diabetic retinopathy, and diabetic peripheral neuropathy was significantly correlated with increase of uric acid level [2.29 (1.01-5.2), 16.01 (4.74-54.09), 9.99 (4.4-22.8), 4.43 (13-15.1), 4.37 (1.5-12.9)], and of microalbuminuria level [7.0 (3.6-13.8), 3.2 (1.2-8.7), NA, 14.7 (5.1-42.7), 7.2 (2.9-17.7)].
   Conclusion: Both elevated uric acid and microalbuminuria levels were significantly associated with diabetic chronic micro/macro-vascular complications. Monitoring of uric acid and microalbuminuria levels provides a predictive value for a presence of chronic micro/macro-vascular complications in patients with type 2 diabetes. (C) 2014 Elsevier Inc. All rights reserved.
C1 [Chuengsamarn, Somlak] Srinakharinwirot Univ, Fac Med, HRH Princess Maha Chakri Sirindhorn Med Ctr, Div Endocrinol & Metab, Nakornnayok, Thailand.
   [Rattanamongkolgul, Suthee] Srinakharinwirot Univ, Fac Med, HRH Princess Maha Chakri Sirindhorn Med Ctr, Dept Prevent & Social Med, Nakornnayok, Thailand.
   [Jirawatnotai, Siwanon] Mahidol Univ, Siriraj Hosp, Fac Med, Dept Pharmacol, Bangkok 10700, Thailand.
C3 Srinakharinwirot University; Srinakharinwirot University; Mahidol
   University
RP Chuengsamarn, S (corresponding author), Srinakharinwirot Univ, Fac Med, HRH Princess Maha Chakri Sirindhorn Med Ctr, Dept Med,Div Endocrinol & Metab, 63 M 7 Rungsit Nakornnayok Rd, Nakornnayok, Thailand.
EM somlukc@swu.ac.th
RI Jirawatnotai, Siwanon/JGD-6875-2023
OI Rattanamongkolgul, Suthee/0000-0001-6628-207X; Jirawatnotai,
   Siwanon/0000-0002-8252-3782
FU Faculty of Medicine for Medical Science, HRH Princess Maha Chakri
   Sirindhorn Medical Center, Srinakharinwirot University
FX This study was funded by a research grant to S.C. from Faculty of
   Medicine for Medical Science, HRH Princess Maha Chakri Sirindhorn
   Medical Center, Srinakharinwirot University.
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NR 41
TC 37
Z9 42
U1 0
U2 20
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1056-8727
EI 1873-460X
J9 J DIABETES COMPLICAT
JI J. Diabetes Complications
PD MAR-APR
PY 2014
VL 28
IS 2
BP 124
EP 129
DI 10.1016/j.jdiacomp.2013.12.002
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA AD8VD
UT WOS:000333542900005
PM 24412514
DA 2025-06-11
ER

PT J
AU Hu, SH
   Yao, MR
   Peterson, BS
   Xu, DR
   Hu, JB
   Tang, JL
   Fan, B
   Liao, ZL
   Yuan, TY
   Li, YL
   Yue, WQ
   Wei, N
   Zhou, WH
   Huang, ML
   Xu, Y
AF Hu, Shaohua
   Yao, Mingrong
   Peterson, Bradley S.
   Xu, Dongrong
   Hu, Jianbo
   Tang, Jianliang
   Fan, Bing
   Liao, Zhengluan
   Yuan, Tianyi
   Li, Yaling
   Yue, Weiqing
   Wei, Ning
   Zhou, Weihua
   Huang, Manli
   Xu, Yi
TI A randomized, 12-week study of the effects of extended-release
   paliperidone (paliperidone ER) and olanzapine on metabolic profile,
   weight, insulin resistance, and β-cell function in schizophrenic
   patients
SO PSYCHOPHARMACOLOGY
LA English
DT Article
DE Metabolic syndrome; Antipsychotic; Paliperidone; Olanzapine; Insulin
   resistance; beta-Cell function
ID ANTIPSYCHOTIC-DRUGS; DOUBLE-BLIND; ATYPICAL ANTIPSYCHOTICS; HOMEOSTASIS
   MODEL; OXIDATIVE STRESS; RISPERIDONE; GAIN; CLOZAPINE; GLUCOSE; TABLETS
AB To compare matched paliperidone-ER- and olanzapine-treated schizophrenic patients on measures of glucose and lipid metabolism.
   Eighty hospitalized patients with schizophrenia (DSM-IV) were randomly assigned to treatment with paliperidone ER or olanzapine for a period of 12 weeks. At baseline and every 4 weeks, we assessed weight, subcutaneous fat, waist and hip circumferences, fasting glucose, insulin, glycohemoglobin A1, cholesterol, triglycerides, high density lipoprotein (HDL) cholesterol, low density lipoprotein (LDL) cholesterol, and prolactin. We also assessed at every time point body mass index (BMI), homeostasis insulin resistance (HOMA-IR), and homeostasis beta-cell function (HOMA-B).
   Thirty-three patients randomly assigned to paliperidone ER and 23 patients randomly assigned to olanzapine groups completed the entire 12-week treatment. Within-group analyses showed that fasting measures in both groups increased for weight, BMI, waist circumferences, hip circumference, subcutaneous fat, cholesterol, triglycerides, and prolactin. In contrast, fasting glucose, LDL, and HOMA-B increased during treatment only in the olanzapine group. We also detected significantly different serum prolactin levels at all time point between the paliperidone ER- and olanzapine-treated groups, as well as a statistical trend for HOMA-B to increase more in the olanzapine compared to paliperidone-ER group over the 12 weeks of the trial. We did not detect, however, differential drug effects over the 12 weeks of the trial on fasting measures of BMI, glucose, glycohemoglobin A1, insulin, HDL, LDL, cholesterol, triglyceride, or HOMA-IR.
   This study reinforces the necessity of regularly monitoring metabolic parameters in patients with schizophrenia taking atypical antipsychotics, including paliperidone ER.
C1 [Hu, Shaohua; Hu, Jianbo; Wei, Ning; Zhou, Weihua; Huang, Manli; Xu, Yi] Zhejiang Univ, Affiliated Hosp 1, Dept Mental Hlth, Sch Med, Hangzhou 310003, Zhejiang, Peoples R China.
   [Yao, Mingrong; Tang, Jianliang; Yuan, Tianyi; Li, Yaling; Yue, Weiqing] Kangci Hosp Jiaxing, Dept Psychiat, Tongxiang 314500, Peoples R China.
   [Peterson, Bradley S.; Xu, Dongrong] Columbia Univ, Dept Psychiat, New York, NY 10032 USA.
   [Peterson, Bradley S.; Xu, Dongrong; Fan, Bing] New York State Psychiat Inst & Hosp, New York, NY 10032 USA.
   [Fan, Bing] Columbia Univ, Dept Child Epidem Psychiat, New York, NY 10032 USA.
   [Liao, Zhengluan] Zhejiang Prov Peoples Hosp, Dept Psychiat, Hangzhou 310014, Zhejiang, Peoples R China.
C3 Zhejiang University; Columbia University; New York State Psychiatry
   Institute; Columbia University; Hangzhou Medical College; Zhejiang
   Provincial People's Hospital
RP Xu, Y (corresponding author), Zhejiang Univ, Affiliated Hosp 1, Dept Mental Hlth, Sch Med, Hangzhou 310003, Zhejiang, Peoples R China.
EM xuyi61@yahoo.com.cn
RI meng, yan/GSE-2653-2022; Yuan, Tianyi/LZH-4449-2025; Hu,
   Shaohua/I-3336-2019
OI Hu, Shaohua/0000-0003-0570-670X
FU Shanghai Commission of Science and Technology [10440710200]
FX This work is partly supported by a grant from Shanghai Commission of
   Science and Technology (No. 10440710200).
CR [Anonymous], POSTGRAD MED
   [Anonymous], EUR NEUROPSYCHOPH S3
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NR 56
TC 21
Z9 23
U1 0
U2 32
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0033-3158
EI 1432-2072
J9 PSYCHOPHARMACOLOGY
JI Psychopharmacology
PD NOV
PY 2013
VL 230
IS 1
BP 3
EP 13
DI 10.1007/s00213-013-3073-1
PG 11
WC Neurosciences; Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA 235FA
UT WOS:000325700700002
PM 23559220
DA 2025-06-11
ER

PT J
AU Puri, K
   Nobili, V
   Melville, K
   Corte, CD
   Sartorelli, MR
   Lopez, R
   Feldstein, AE
   Alkhouri, N
AF Puri, Kanika
   Nobili, Valerio
   Melville, Katherine
   Corte, Claudia D.
   Sartorelli, Maria R.
   Lopez, Rocio
   Feldstein, Ariel E.
   Alkhouri, Naim
TI Serum Bilirubin Level Is Inversely Associated With Nonalcoholic
   Steatohepatitis in Children
SO JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
LA English
DT Article
DE antioxidant; bilirubin; children; histology; nonalcoholic fatty liver
   disease; nonalcoholic steatohepatitis
ID FATTY LIVER-DISEASE; INSULIN-RESISTANCE; METABOLIC SYNDROME; BILIVERDIN
   REDUCTASE; DIABETES-MELLITUS; OBESITY; ANTIOXIDANT; ADOLESCENTS; RISK;
   SENSITIVITY
AB Objectives:Oxidative stress has been implicated in the development of nonalcoholic fatty liver disease (NAFLD) and progression to the more severe form, nonalcoholic steatohepatitis (NASH), in children. We aimed to study the clinical correlation between bilirubin, a potent endogenous antioxidant with cytoprotective properties, and histopathological findings in pediatric patients with NAFLD.Methods:We included consecutive children with biopsy-proven NAFLD and obtained demographic, clinical, and histopathological data. We performed logistic regression analysis to assess the clinical factors associated with the histological features of NASH or fibrosis.Results:From a total of 302 biopsies, 67% (203) had evidence of NASH, whereas 64.2% had some degree of fibrosis (stage 1 in 51%, stage 2 in 6.3%, and stage 3 in 6.6%). Mean total bilirubin was significantly lower in the NASH group compared with the non-NASH group (0.650.24 vs 0.73 +/- 0.22 mg/dL, P=0.007). Higher total bilirubin levels were negatively correlated with the presence of steatosis and the NAFLD activity score (P<0.05), whereas a trend in that direction was observed for presence of fibrosis and inflammation (P=0.051). On multivariable analysis, higher bilirubin levels were significantly associated with a decreased likelihood of a histological diagnosis of NASH on biopsy (odds ratio 0.29, 95% CI 0.10-0.85, P=0.024).Conclusions:In children with NAFLD, there is an inverse relation between serum bilirubin levels and the presence of NASH on biopsy. This may be secondary to the antioxidant effect of bilirubin.
C1 [Puri, Kanika] SUNY Downstate, Dept Pediat, Brooklyn, NY USA.
   [Melville, Katherine; Alkhouri, Naim] Cleveland Clin, Dept Pediat Gastroenterol, Cleveland, OH 44195 USA.
   [Lopez, Rocio] Cleveland Clin, Cleveland, OH 44195 USA.
   [Nobili, Valerio; Corte, Claudia D.; Sartorelli, Maria R.] Bambino Gesu Childrens Hosp & Res Inst, Liver Unit, Rome, Italy.
   [Feldstein, Ariel E.] Univ Calif San Diego, Dept Pediat Gastroenterol, Rady Childrens Hosp, San Diego, CA 92103 USA.
C3 State University of New York (SUNY) System; SUNY Downstate Health
   Sciences University; Cleveland Clinic Foundation; Cleveland Clinic
   Foundation; IRCCS Bambino Gesu; University of California System;
   University of California San Diego; Rady Childrens Hospital San Diego
RP Alkhouri, N (corresponding author), Cleveland Clin, Dept Pediat Gastroenterol, Inst Digest Dis, A-31,9500 Euclid Ave, Cleveland, OH 44195 USA.
EM alkhoun@ccf.org
RI della corte, claudia/N-4563-2015; Nobili, Valerio/K-8670-2018
OI nobili, valerio/0000-0002-4570-3979; Sartorelli,
   Mariarita/0000-0002-3725-1677; Lopez Moscoso, Ana
   Rocio/0000-0002-4319-420X; Puri, Kanika/0009-0004-5157-1652
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NR 33
TC 50
Z9 54
U1 0
U2 10
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0277-2116
EI 1536-4801
J9 J PEDIATR GASTR NUTR
JI J. Pediatr. Gastroenterol. Nutr.
PD JUL
PY 2013
VL 57
IS 1
BP 114
EP 118
DI 10.1097/MPG.0b013e318291fefe
PG 5
WC Gastroenterology & Hepatology; Nutrition & Dietetics; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Nutrition & Dietetics; Pediatrics
GA 248ZD
UT WOS:000326744500030
PM 23518490
OA Bronze
DA 2025-06-11
ER

PT J
AU Zhou, YB
   Gao, Q
   Li, P
   Han, Y
   Zhang, F
   Qi, YF
   Tang, CS
   Gao, XY
   Zhu, GQ
AF Zhou, Y. -B.
   Gao, Q.
   Li, P.
   Han, Y.
   Zhang, F.
   Qi, Y. -F.
   Tang, C. -S.
   Gao, X. -Y.
   Zhu, G. -Q.
TI Adrenomedullin attenuates vascular calcification in fructose-induced
   insulin resistance rats
SO ACTA PHYSIOLOGICA
LA English
DT Article
DE adrenomedullin; insulin resistance; metabolic syndrome; vascular
   calcification; vascular smooth muscle cells
ID SMOOTH-MUSCLE-CELLS; MEDIAL ARTERY CALCIFICATION; TUMOR-NECROSIS-FACTOR;
   OXIDATIVE STRESS; UP-REGULATION; CARDIOVASCULAR COMPLICATIONS;
   ALKALINE-PHOSPHATASE; PLUS NICOTINE; MESSENGER-RNA; HYPERTENSION
AB Aim To determine the therapeutic effects of adrenomedullin (ADM) on vascular calcification and related molecular mechanism in fructose-induced insulin resistance rats. Methods Rats received ordinary drinking water or 10% fructose in drinking water for 12weeks and subcutaneous injection of normal saline or ADM (3.6g kg1) twice a day for the last 4weeks. Levels of ADM, calcitonin receptor-like receptors (CRLR), receptor activity-modifying proteins (RAMP) as well as calcium content, alkaline phosphatase (ALP) activity, osteoblastic and contractile smooth muscle markers in aortic media were measured. Results The levels of ADM, CRLR, RAMP2 and RAMP3 in aortic media were increased in fructose-fed rats. ADM treatment attenuated the fructose-induced insulin resistance, increased blood pressure, fasting glucose, insulin, triglycerides and cholesterol levels. It improved VSMCs proliferation and disordered arrangement and hyperplasia of elastic fibres in fructose-fed rats. Calcium deposits, calcium content and ALP activity in the aortic media were increased in fructose-fed rats, which were attenuated by ADM treatment. The osteoblastic markers such as osteopontin (OPN), bone morphogenetic protein 2 (BMP2) proteins and core binding factor alpha-1 (Cbf-1) protein and mRNA expressions were increased in fructose-fed rats. ADM treatment increased the OPN protein expression, but reduced the BMP2 protein, Cbf-1 protein and mRNA expression. Contractile smooth muscle markers such as -actin and smooth muscle 22 (SM-22) were downregulated in fructose-fed rats, which were recovered by ADM treatment. Conclusion Administration of ADM attenuates insulin resistance, calcium deposition and osteogenic transdifferentiation in aortic media in fructose-fed rats.
C1 [Zhou, Y. -B.; Gao, Q.; Li, P.; Han, Y.; Zhang, F.; Gao, X. -Y.; Zhu, G. -Q.] Nanjing Med Univ, Dept Physiol, Key Lab Cardiovasc Dis & Mol Intervent, Nanjing 210029, Jiangsu, Peoples R China.
   [Qi, Y. -F.; Tang, C. -S.] Minist Educ, Key Lab Mol Cardiovasc Sci, Beijing, Peoples R China.
C3 Nanjing Medical University; Ministry of Education - China
RP Zhu, GQ (corresponding author), Nanjing Med Univ, Dept Physiol, Key Lab Cardiovasc Dis & Mol Intervent, 140 Hanzhong Rd, Nanjing 210029, Jiangsu, Peoples R China.
EM gqzhucn@njmu.edu.cn
RI li, peng/HKN-2819-2023; Zhang, faming/GRY-2130-2022
OI Zhu, Guo-Qing/0000-0002-3132-9592; Zhou, Yebo/0000-0001-9465-1338; Han,
   Ying/0000-0001-8591-7894; Li, Peng/0000-0003-0365-2103
FU Chinese National Natural Science foundation [81000106, 31171095];
   Natural Science Foundation, Department of education of Jiangsu Province
   [10KJB310004]; Science and Technology Foundation, Nanjing Medical
   University [09NJMUZ04, 09JC013]; Priority Academic Program Development
   of Jiangsu Higher Education Institutions (PAPD)
FX This work was supported by Chinese National Natural Science foundation
   (81000106 & 31171095), Natural Science Foundation from Department of
   education of Jiangsu Province (10KJB310004), Science and Technology
   Foundation from Nanjing Medical University (09NJMUZ04 & 09JC013) and a
   project funded by the Priority Academic Program Development of Jiangsu
   Higher Education Institutions (PAPD).
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NR 53
TC 23
Z9 23
U1 0
U2 14
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1748-1708
EI 1748-1716
J9 ACTA PHYSIOL
JI Acta Physiol.
PD MAR
PY 2013
VL 207
IS 3
BP 437
EP 446
DI 10.1111/apha.12033
PG 10
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA 091YS
UT WOS:000315086300005
PM 23121999
DA 2025-06-11
ER

PT J
AU Botezelli, JD
   Cambri, LT
   Ghezzi, AC
   Dalia, RA
   Voltarelli, FA
   de Mello, MAR
AF Botezelli, Jose Diego
   Cambri, Lucieli Teresa
   Ghezzi, Ana Carolina
   Dalia, Rodrigo Augusto
   Voltarelli, Fabricio Azevedo
   Rostom de Mello, Maria Alice
TI Fructose-rich diet leads to reduced aerobic capacity and to liver injury
   in rats
SO LIPIDS IN HEALTH AND DISEASE
LA English
DT Article
DE Fructose; Liver injury; Oxidative stress; Rats
ID INSULIN-RESISTANCE; METABOLIC SYNDROME; SKELETAL-MUSCLE; FATTY-ACIDS;
   GLUCOSE; ASSOCIATION; BEVERAGES; DISEASE; MARKERS; FLUX
AB The main purpose of this research was to investigate the alterations in the aerobic capacity and appearance of metabolic alterations in Wistar rats fed on fructose-rich diet. We separated twenty-eight rats into two groups according to diet: a control group (C) (balanced diet) and a fructose-rich diet group (F). The animals were fed these diets for 60 d (d 120 to 180). We performed insulin, glucose as well as a minimum lactate test, at d 120 and 180. At the end of the experiment, sixteen animals were euthanized, and the following main variables were analysed: aerobic capacity, the serum aspartate aminotransferase (AST) to alanine aminotransferase (ALT) ratio, serum and liver triglyceride concentrations, serum and liver thiobarbituric acid reactive substance (TBARS) concentrations, serum and liver catalase and superoxide dismutase (SOD) activity and haematoxylin-eosin histology (HE) in hepatocytes. The remaining twelve animals were submitted to an analysis of their hepatic lipogenic rate. The animals fed a fructose-rich diet exhibited a reduction in aerobic capacity, glucose tolerance and insulin sensitivity and increased concentrations of triglycerides and TBARS in the liver. Catalase and SOD activities were reduced in the livers of the fructose-fed animals. In addition, the serum AST/ALT ratio was higher than that of the C group, which indicates hepatic damage, and the damage was confirmed by histology. In conclusion, the fructose-rich diet caused significant liver damage and a reduction in insulin sensitivity in the animals, which could lead to deleterious metabolic effects.
C1 [Botezelli, Jose Diego; Cambri, Lucieli Teresa; Ghezzi, Ana Carolina; Dalia, Rodrigo Augusto; Rostom de Mello, Maria Alice] Sao Paulo State Univ, UNESP, Dept Phys Educ, BR-13506900 Sao Paulo, Brazil.
   [Voltarelli, Fabricio Azevedo] Univ Fed Mato Grosso, Dept Phys Educ, Grosso, MT, Brazil.
C3 Universidade Estadual Paulista; Universidade Federal de Mato Grosso
RP Botezelli, JD (corresponding author), Sao Paulo State Univ, UNESP, Dept Phys Educ, Av 24-A,1515 Bela Vista, BR-13506900 Sao Paulo, Brazil.
EM jdbotezelli@yahoo.com.br
RI Voltarelli, Fabrício/M-6496-2019; Cambri, Lucieli/I-5964-2012
FU Brazilian foundation FAPESP [2009/15336-9]; Brazilian foundation CNPq;
   Brazilian foundation CAPES
FX This work was supported by Brazilian foundations FAPESP [grant number
   2009/15336-9], CNPq and CAPES. The authors also thank to Sibuya CY and
   Silva JRR for the expert technical assistance.
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NR 51
TC 42
Z9 44
U1 0
U2 5
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1476-511X
J9 LIPIDS HEALTH DIS
JI Lipids Health Dis.
PD JUN 19
PY 2012
VL 11
AR 78
DI 10.1186/1476-511X-11-78
PG 9
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA 021GJ
UT WOS:000309873000001
PM 22713601
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Wu, GY
AF Wu, Guoyao
TI Amino acids: metabolism, functions, and nutrition
SO AMINO ACIDS
LA English
DT Review
DE Amino acids; Health; Metabolism; Nutrition
ID DIETARY ARGININE SUPPLEMENTATION; NITRIC-OXIDE SYNTHESIS; STIMULATES
   PROTEIN-SYNTHESIS; SKELETAL-MUSCLE; GENE-EXPRESSION;
   DEVELOPMENTAL-CHANGES; SELECT NUTRIENTS; GLUTAMINE-SYNTHETASE;
   SMALL-INTESTINE; NEONATAL PIGS
AB Recent years have witnessed the discovery that amino acids (AA) are not only cell signaling molecules but are also regulators of gene expression and the protein phosphorylation cascade. Additionally, AA are key precursors for syntheses of hormones and low-molecular weight nitrogenous substances with each having enormous biological importance. Physiological concentrations of AA and their metabolites (e.g., nitric oxide, polyamines, glutathione, taurine, thyroid hormones, and serotonin) are required for the functions. However, elevated levels of AA and their products (e.g., ammonia, homocysteine, and asymmetric dimethylarginine) are pathogenic factors for neurological disorders, oxidative stress, and cardiovascular disease. Thus, an optimal balance among AA in the diet and circulation is crucial for whole body homeostasis. There is growing recognition that besides their role as building blocks of proteins and polypeptides, some AA regulate key metabolic pathways that are necessary for maintenance, growth, reproduction, and immunity. They are called functional AA, which include arginine, cysteine, glutamine, leucine, proline, and tryptophan. Dietary supplementation with one or a mixture of these AA may be beneficial for (1) ameliorating health problems at various stages of the life cycle (e.g., fetal growth restriction, neonatal morbidity and mortality, weaning-associated intestinal dysfunction and wasting syndrome, obesity, diabetes, cardiovascular disease, the metabolic syndrome, and infertility); (2) optimizing efficiency of metabolic transformations to enhance muscle growth, milk production, egg and meat quality and athletic performance, while preventing excess fat deposition and reducing adiposity. Thus, AA have important functions in both nutrition and health.
C1 Texas A&M Univ, Dept Anim Sci, Fac Nutr, College Stn, TX 77843 USA.
C3 Texas A&M University System; Texas A&M University College Station
RP Wu, GY (corresponding author), Texas A&M Univ, Dept Anim Sci, Fac Nutr, College Stn, TX 77843 USA.
EM g-wu@tamu.edu
FU National Institutes of Health [1R21 HD049449]; USDA Cooperative State
   Research, Education, and Extension Service [2008-35206-18764,
   2008-35206-18762, 2008-35203-19120]; American Heart Association
   [0755024Y]; Texas AgriLife Research [H-8200]; American Heart Association
   (AHA) [0755024Y] Funding Source: American Heart Association (AHA)
FX This work was supported, in part, by grants from National Institutes of
   Health (1R21 HD049449), National Research Initiative Competitive Grants
   (2008-35206-18764, 2008-35206-18762, and 2008-35203-19120) from the USDA
   Cooperative State Research, Education, and Extension Service, American
   Heart Association (#0755024Y), and Texas AgriLife Research (H-8200). The
   author thanks graduate students, postdoctoral fellows, technicians, and
   colleagues for their important contributions to the work described in
   this article.
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NR 154
TC 2048
Z9 2364
U1 39
U2 241
PU SPRINGER WIEN
PI WIEN
PA SACHSENPLATZ 4-6, PO BOX 89, A-1201 WIEN, AUSTRIA
SN 0939-4451
EI 1438-2199
J9 AMINO ACIDS
JI Amino Acids
PD MAY
PY 2009
VL 37
IS 1
BP 1
EP 17
DI 10.1007/s00726-009-0269-0
PG 17
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 440FE
UT WOS:000265685400001
PM 19301095
DA 2025-06-11
ER

PT J
AU Nieminen, P
   Mustonen, AM
   Kärjä, V
   Asikainen, J
   Rouvinen-Watt, K
AF Nieminen, Petteri
   Mustonen, Anne-Mari
   Karja, Vesa
   Asikainen, Juha
   Rouvinen-Watt, Kirsti
TI Fatty Acid Composition and Development of Hepatic Lipidosis During Food
   Deprivation-Mustelids as a Potential Animal Model for Liver Steatosis
SO EXPERIMENTAL BIOLOGY AND MEDICINE
LA English
DT Article
DE fatty acids; hepatic lipidosis; Mustela putorius; NAFLD; PUFA
ID GENE-EXPRESSION; ADIPOSE-TISSUES; RECEPTOR-ALPHA; MINK; VISON;
   MOBILIZATION; ADAPTATIONS; FERRETS; DIET; STEATOHEPATITIS
AB Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of the metabolic syndrome characterized by asymptomatic hepatic steatosis. It is present in most cases of human obesity but also caused e.g., by rapid weight loss. The patients have decreased n-3 polyunsaturated fatty acid (PUFA) proportions with decreased percentages of 18:3(n-3), 20:5(n-3) and 22:6(n-3) and an increased n-6/n-3 PUFA ratio in liver and/or white adipose tissue (WAT). The present study examined a new experimental model to study liver steatosis with possible future applications to NAFLD. Ten European polecats (Mustela putorius), the wild form of the domestic ferret, were food-deprived for 5 days with 10 fed animals as controls. The food-deprived animals showed micro- and macrovesicular hepatic steatosis, decreased proportions of 20:5(n-3), 22:6(n-3) and total n-3 PUFA and increased n-6/n-3 PUFA ratios in liver and WAT. At the same time, the product/precursor ratios decreased in liver. The observed effects can be due to selective fatty acid mobilization preferring n-3 PUFA over n-6 PUFA, decreased Delta 5 and Delta 6 desaturase activities, oxidative stress, decreased arginine availability and activation of the endocannabinoid system. Hepatic lipidosis induced by food deprivation was manifested in the fatty acid composition of the polecat with similarities to human NAFLD despite the different principal etiologies. Exp Biol Med 234:278-286, 2009
C1 [Nieminen, Petteri; Mustonen, Anne-Mari; Asikainen, Juha] Univ Jocnsuu, Fac Biosci, POB 111, FI-80101 Joensuu, Finland.
   [Nieminen, Petteri] Univ Oulu, Fac Med, Inst Biomed, Dept Anat & Cell Biol, FI-90014 Oulu, Finland.
   [Karja, Vesa] Kuopio Univ Hosp, Dept Clin Pathol, FI-70211 Kuopio, Finland.
   [Rouvinen-Watt, Kirsti] Nova Scotia Agr Coll, Dept Plant & Anim Sci, Truro, NS B2N 5E3, Canada.
C3 University of Eastern Finland; University of Oulu; University of Eastern
   Finland; University of Eastern Finland Hospital; Kuopio University
   Hospital; Dalhousie University
RP Nieminen, P (corresponding author), Univ Jocnsuu, Fac Biosci, POB 111, FI-80101 Joensuu, Finland.
EM pniemine@cc.joensuu.fi
FU Academy of Finland; Natural Sciences and Engineering Research Council of
   Canada
FX This work was funded by grants from the Academy of Finland (PN and AMM)
   and the Natural Sciences and Engineering Research Council of Canada
   (Discovery Grant to KRW).
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TC 20
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U2 13
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1535-3702
EI 1535-3699
J9 EXP BIOL MED
JI Exp. Biol. Med.
PD MAR
PY 2009
VL 234
IS 3
BP 278
EP 286
DI 10.3181/0806-RM-210
PG 9
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 412ZE
UT WOS:000263761900006
PM 19144866
DA 2025-06-11
ER

PT J
AU Wiering, L
   Tacke, F
AF Wiering, Leke
   Tacke, Frank
TI Treating inflammation to combat non-alcoholic fatty liver disease
SO JOURNAL OF ENDOCRINOLOGY
LA English
DT Review
DE non-alcoholic fatty liver disease; non-alcoholic steatohepatitis; liver;
   metabolic syndrome; inflammation
ID ENDOPLASMIC-RETICULUM STRESS; INSULIN-RESISTANCE; DOUBLE-BLIND;
   MACROPHAGE INFILTRATION; HEPATIC INFLAMMATION; OBETICHOLIC ACID; CELL
   ACTIVATION; KUPFFER CELLS; STEATOHEPATITIS; FIBROSIS
AB Non-alcoholic fatty liver disease (NAFLD) with its more progressive form non-alcoholic steatohepatitis (NASH) has become the most common chronic liver disease, thereby representing a great burden for patients and healthcare systems. Specific pharmacological therapies for NAFLD are still missing. Inflammation is an important driver in the pathogenesis of NASH, and the mechanisms underlying inflammation in NAFLD represent possible therapeutic targets. In NASH, various intra- and extrahepatic triggers involved in the metabolic injury typically lead to the activation of different immune cells. This includes hepatic Kupffer cells, i.e. liver-resident macrophages, which can adopt an inflammatory phenotype and activate other immune cells by releasing inflammatory cytokines. As inflammation progresses, Kupffer cells are increasingly replaced by monocyte-derived macrophages with a distinct lipid-associated and scar-associated phenotype. Many other immune cells, including neutrophils, T lymphocytes - such as auto-aggressive cytotoxic as well as regulatory T cells - and innate lymphoid cells balance the progression and regression of inflammation and subsequent fibrosis. The detailed understanding of inflammatory cell subsets and their activation pathways prompted preclinical and clinical exploration of potential targets in NAFLD/NASH. These approaches to target inflammation in NASH include inhibition of immune cell recruitment via chemokine receptors (e.g. cenicriviroc), neutralization of CD44 or galectin-3 as well as agonism to nuclear factors like peroxisome proliferator-activated receptors and farnesoid X receptor that interfere with the activation of immune cells. As some of these approaches did not demonstrate convincing efficacy as monotherapies, a rational and personalized combination of therapeutic interventions may be needed for the near future.
C1 [Wiering, Leke; Tacke, Frank] Charite Univ Med Berlin, Berlin, Germany.
   [Wiering, Leke; Tacke, Frank] Free Univ Berlin, Berlin, Germany.
   [Wiering, Leke; Tacke, Frank] Humboldt Univ, Dept Hepatol & Gastroenterol, Campus Virchow Klinikum, Berlin, Germany.
   [Wiering, Leke; Tacke, Frank] Campus Charite Mitte, Berlin, Germany.
   [Wiering, Leke] Charite Univ Med Berlin, Berlin Inst Hlth, BIH Biomed Innovat Acad, BIH Charite Jr Clinician Scientist Program, Berlin, Germany.
C3 Berlin Institute of Health; Free University of Berlin; Humboldt
   University of Berlin; Charite Universitatsmedizin Berlin; Free
   University of Berlin; Berlin Institute of Health; Free University of
   Berlin; Humboldt University of Berlin; Charite Universitatsmedizin
   Berlin; Berlin Institute of Health; Free University of Berlin; Humboldt
   University of Berlin; Charite Universitatsmedizin Berlin; Berlin
   Institute of Health; Free University of Berlin; Humboldt University of
   Berlin; Charite Universitatsmedizin Berlin
RP Tacke, F (corresponding author), Charite Univ Med Berlin, Berlin, Germany.; Tacke, F (corresponding author), Free Univ Berlin, Berlin, Germany.; Tacke, F (corresponding author), Humboldt Univ, Dept Hepatol & Gastroenterol, Campus Virchow Klinikum, Berlin, Germany.; Tacke, F (corresponding author), Campus Charite Mitte, Berlin, Germany.
EM frank.tacke@charite.de
RI Tacke, Frank/ABF-2212-2020
OI Wiering, Leke/0000-0003-4144-3652; Tacke, Frank/0000-0001-6206-0226
FU German Research Foundation [DFG SFB/TRR 296, CRC1382]; German Ministry
   of Education and Research (BMBF DEEP-HCC consortium); Gilead; Allergan;
   Bristol-Myers Squibb; Inventiva;  [403224013]
FX This work was funded by the German Research Foundation (DFG SFB/TRR 296
   and CRC1382, Project-ID 403224013) and the German Ministry of Education
   and Research (BMBF DEEP-HCC consortium). FT's lab received research
   grants from Gilead, Allergan, Bristol-Myers Squibb and Inventiva.
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NR 174
TC 36
Z9 36
U1 2
U2 37
PU BIOSCIENTIFICA LTD
PI BRISTOL
PA STARLING HOUSE, 1600 BRISTOL PARKWAY N, BRISTOL, ENGLAND
SN 0022-0795
EI 1479-6805
J9 J ENDOCRINOL
JI J. Endocrinol.
PD JAN 1
PY 2023
VL 256
IS 1
AR e220194
DI 10.1530/JOE-22-0194
PG 20
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA Z0QB4
UT WOS:001109203900001
PM 36259984
OA Bronze
DA 2025-06-11
ER

PT J
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TI Research Trends in Advanced Glycation End Products and Obesity:
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SO NUTRIENTS
LA English
DT Article
DE advanced glycation end products; bibliometric analysis; obesity;
   VOSviewer
ID DIABETES-MELLITUS; METABOLIC SYNDROME; OXIDATIVE STRESS; FOODS; DISEASE;
   INFLAMMATION; ENDPRODUCTS; AGES; N-EPSILON-(CARBOXYMETHYL)LYSINE;
   HEALTHY
AB The aim of this study was to conduct a bibliometric analysis of the scientific articles on advanced glycation end products (AGEs) and obesity. English-language journal articles about AGEs and obesity were retrieved from the Scopus database. The OpenRefine application was used for data cleaning, the VOSviewer software program for analysis of the trends of year of publication, country, institution, journal, authors, references, and keywords. Microsoft Excel and Tableau Public were applied for the visualizing of the publication trends. Data collection was performed on 3 February 2022, from a total of 1170 documents. The Mann-Whitney test and Spearman test with software SPSS ver.28.0.1.1. were used to assess the relation between open access journal statuses, years of publications, and CiteScore. The results of the study showed that there was an increase in studies on processed foods, including AGEs and obesity. The United States was the country with the largest contribution in this field, with the highest number of citations. The Nutrients journal published the largest number of articles on this topic, particularly in the last two years. The present focus of the studies is on ultra-processed foods. The open access journals have younger medians of the year of publication and higher medians for number of citations than do closed access journals (p < 0.001 and p < 0.05, respectively). A strong negative association was seen between CiteScore and the year of publication (r = -0.64 [95% CI: -0.67, -0.60]), p < 0.001. We present this bibliometric analysis to furnish the most recent data on the description, visualization, and analysis of AGEs and obesity.
C1 [Liman, Patricia Budihartanti; Anastasya, Karina Shasri] Univ Trisakti, Fac Med, Dept Nutr, Jakarta 11440, Indonesia.
   [Liman, Patricia Budihartanti] Univ Trisakti, Fac Med, Nutr Study Ctr, Jakarta 11440, Indonesia.
   [Liman, Patricia Budihartanti] Ciputra Hosp Tangerang, Tangerang 15710, Indonesia.
   [Salma, Nabila Maudy] Univ Trisakti, Fac Med, Dept Anat, Jakarta 11440, Indonesia.
   [Yenny, Yenny] Univ Trisakti, Fac Med, Dept Pharmacol & Med Pharm, Jakarta 11440, Indonesia.
   [Faradilla, Meutia Atika] Univ Trisakti, Fac Med, Dept Biochem, Jakarta 11440, Indonesia.
C3 Universitas Trisakti; Universitas Trisakti; Universitas Trisakti;
   Universitas Trisakti; Universitas Trisakti
RP Liman, PB (corresponding author), Univ Trisakti, Fac Med, Dept Nutr, Jakarta 11440, Indonesia.; Liman, PB (corresponding author), Univ Trisakti, Fac Med, Nutr Study Ctr, Jakarta 11440, Indonesia.; Liman, PB (corresponding author), Ciputra Hosp Tangerang, Tangerang 15710, Indonesia.
EM patricialiman@trisakti.ac.id
RI , Yenny/AAL-8702-2020; Liman, Patricia/AAL-7881-2020; Salma,
   Nabila/MFI-8198-2025
OI Liman, Patricia Budihartanti/0000-0002-3077-5566; ,
   Yenny/0000-0001-9390-5527; Faradilla, Meutia Atika/0009-0006-1216-5891
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NR 71
TC 6
Z9 6
U1 4
U2 23
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD DEC
PY 2022
VL 14
IS 24
AR 5255
DI 10.3390/nu14245255
PG 21
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 7H4MP
UT WOS:000903178500001
PM 36558414
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Zhang, R
   Huang, XM
   Li, Y
   Yu, ZY
   Wu, YY
   Zha, BB
   Ding, HY
   Zang, SF
   Liu, J
AF Zhang, Rui
   Huang, Xinmei
   Li, Yue
   Yu, Zhiyan
   Wu, Yueyue
   Zha, Bingbing
   Ding, Heyuan
   Zang, Shufei
   Liu, Jun
TI Serum ferritin as a risk factor for type 2 diabetes mellitus, regulated
   by liver transferrin receptor 2
SO ENDOCRINE CONNECTIONS
LA English
DT Article
DE type 2 diabetes; serum ferritin; transferrin receptor 2
ID INSULIN-RESISTANCE; METABOLIC SYNDROME; OXIDATIVE STRESS;
   IRON-METABOLISM; HEPCIDIN; EXPRESSION
AB Objective: The aim of this study was to evaluate the effect of TFR2 on iron storage in type 2 diabetes.
   Methods: A cross-sectional study was conducted among 1938 participants from the Jiangchuan Community of Shanghai. A total of 784 participants with T2DM and 1154 normal participants (non-T2DM) were enrolled in this study. Serum ferritin, fasting blood glucose, postprandial blood glucose, and HbA1C (glycated hemoglobin A1c) levels were determined. Eighteen Wistar male rats were randomly assigned into three groups (n = 6/group): rats in a high-fat diet streptozotocin (HFD+STZ) group were fed with HFD for 4 weeks and intraperitoneally injected with streptozotocin (STZ); rats in a control group were fed with a standard diet for 4 weeks and intraperitoneally injected with buffer; rats in an STZ group were fed with a standard diet for 4 weeks and intraperitoneally injected with streptozotocin. Glucose tolerance test was performed at the end of the study. Blood samples and liver tissues were assessed for liver TFR2, blood glucose, serum ferritin, and iron levels.
   Results: The mean serum ferritin level of T2DM participants was significantly higher than that of the control group (227 (140-352) vs 203.5 (130.5-312) ng/mL, P < 0.05). Serum ferritin level was an independent risk factor for T2DM (high ferritin group vs low ferritin group, 1.304 (1.03-1.651), P < 0.05). Diabetic rats showed reduced liver TFR2 levels, with increased serum ferritin levels.
   Conclusion: T2DM participants exhibited iron disorder with elevated serum ferritin levels. Elevated serum ferritin levels in diabetic rats were accompanied by reduced liver TFR2 levels.
C1 [Zhang, Rui; Huang, Xinmei; Li, Yue; Yu, Zhiyan; Wu, Yueyue; Zha, Bingbing; Ding, Heyuan; Zang, Shufei; Liu, Jun] Fudan Univ, Shanghai Peoples Hosp 5, Dept Endocrinol, Shanghai, Peoples R China.
C3 Fudan University
RP Zang, SF; Liu, J (corresponding author), Fudan Univ, Shanghai Peoples Hosp 5, Dept Endocrinol, Shanghai, Peoples R China.
EM sophiazsf@fudan.edu.cn; liu_jun@fudan.edu.cn
RI Liu, Jun/AAC-9209-2019; Zhang, Ruibin/HSI-1378-2023; YU,
   ZHIYAN/GXW-2622-2022
FU Shanghai Minhang District Natural Science Foundation [2019MHZ066];
   Medical Key Faculty Foundation of Shanghai [ZK2019B15]; Shanghai Fifth
   People's Hospital Key Project [2018WYZD04]; Shanghai Fifth People's
   Hospital Incubation Project [2018WYFY02]; Health Profession Clinical
   Research Funds of Shanghai Municipal Health Commission [201940295]
FX This study was funded by Shanghai Minhang District Natural Science
   Foundation (grant number: 2019MHZ066), Medical Key Faculty Foundation of
   Shanghai (ZK2019B15), Shanghai Fifth People's Hospital Key Project
   (grant number: 2018WYZD04), and Shanghai Fifth People's Hospital
   Incubation Project (grant number: 2018WYFY02). Health Profession
   Clinical Research Funds of Shanghai Municipal Health Commission (Grant
   number: 201940295).
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NR 26
TC 7
Z9 7
U1 0
U2 7
PU BIOSCIENTIFICA LTD
PI BRISTOL
PA STARLING HOUSE, 1600 BRISTOL PARKWAY N, BRISTOL, ENGLAND
EI 2049-3614
J9 ENDOCR CONNECT
JI Endocr. Connect.
PD DEC 1
PY 2021
VL 10
IS 12
BP 1513
EP 1521
DI 10.1530/EC-21-0316
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA YT3XL
UT WOS:000751296500002
PM 34727090
DA 2025-06-11
ER

PT J
AU Wang, DD
   Zhang, L
   Huang, JS
   Himabindu, K
   Tewari, D
   Horbanczuk, JO
   Xu, SW
   Chen, Z
   Atanasov, AG
AF Wang, Dongdong
   Zhang, Lu
   Huang, Jiansheng
   Himabindu, K.
   Tewari, Devesh
   Horbanczuk, Jaroslaw O.
   Xu, Suowen
   Chen, Zhu
   Atanasov, Atanas G.
TI Cardiovascular protective effect of black pepper (Piper nigrum
   L.) and its major bioactive constituent piperine
SO TRENDS IN FOOD SCIENCE & TECHNOLOGY
LA English
DT Review
DE Atherosclerosis; Hypertension; Thrombosis; Myocardial ischemia; Cardiac
   injury; Cardiovascular diseases
ID HIGH-FAT DIET; VITRO ANTIOXIDANT ACTIVITY; NF-KAPPA-B;
   PLATELET-AGGREGATION; METABOLIC SYNDROME; OXIDATIVE STRESS;
   NATURAL-PRODUCTS; INHIBITION; EXTRACTS; ATHEROSCLEROSIS
AB Background: Cardiovascular diseases (CVDs) are the leading cause of death worldwide. Black pepper, the fruits of Piper nigrum L., is well known as "the king of spices" and used as seasoning and condiments globally. In addition to being an important food additive, black pepper is also used as a traditional medicine to treat vomiting, abdominal pain, and diarrhea, among others. Piperine is a major pungent alkaloid identified in the fruits of P. nigrum (black pepper), whose content is at a range of similar to 5-13%. Black pepper and piperine have shown protective effect on CVDs.
   Scope and approach: Literature search was conducted to systematically review the cardiovascular protective effect of both black pepper and its major bioactive constituent piperine.
   Key findings and conclusions: Black pepper was reported to regulate lipid metabolism, inflammation, and oxidation status in CVDs. Piperine exhibited beneficial effect by targeting many processes associated with atherosclerosis. Piperine is able to prevent lipid peroxidation, oxidized low-density lipoprotein uptake in macrophages, lipid droplet formation, and adhesion of inflammatory cells to endothelial monolayer, promote cholesterol efflux from macrophages, as well as improve lipid profile. Besides, piperine may ameliorate myocardial ischemia, cardiac injury, and cardiac fibrosis, exhibit antihypertensive and antithrombosis effect, as well as prevent arterial stenosis by inhibiting vascular smooth muscle cell proliferation. The summarized information could provide the basis to develop black pepper or piperine as a food additive to prevent or treat CVDs.
C1 [Wang, Dongdong] McMaster Univ, Ctr Metab Obes & Diabet Res, 1280 Main St W, Hamilton, ON L8N 3Z5, Canada.
   [Zhang, Lu] Shandong Univ Tradit Chinese Med, Coll Tradit Chinese Med, Da Xue Rd 4655, Jinan 250355, Peoples R China.
   [Huang, Jiansheng] Vanderbilt Univ, Dept Med, Med Ctr, 318 Preston Res Bldg,2200 Pierce Ave, Nashville, TN 37232 USA.
   [Himabindu, K.; Tewari, Devesh] Lovely Profess Univ, Sch Pharmaceut Sci, Phagwara, Punjab, India.
   [Horbanczuk, Jaroslaw O.; Atanasov, Atanas G.] Polish Acad Sci, Dept Biotechnol & Nutrigen, Inst Genet & Anim Biotechnol, PL-05552 Jastrzebiec, Poland.
   [Xu, Suowen] Univ Sci & Technol China, Div Life Sci & Med, Hefei, Anhui, Peoples R China.
   [Chen, Zhu] Guizhou Univ Tradit Chinese Med, Affiliated Hosp 2, Fei Shan Jie 32, Guiyang 550003, Peoples R China.
   [Atanasov, Atanas G.] Med Univ Vienna, Ludwig Boltzmann Inst Digital Hlth & Patient Safe, Spitalgasse 23, A-1090 Vienna, Austria.
   [Atanasov, Atanas G.] Univ Vienna, Dept Pharmacognosy, Althanstr 14, A-1090 Vienna, Austria.
   [Atanasov, Atanas G.] Bulgarian Acad Sci, Inst Neurobiol, 23 Acad G Bonchev Str, Sofia 1113, Bulgaria.
C3 McMaster University; Shandong University of Traditional Chinese
   Medicine; Vanderbilt University; Lovely Professional University;
   Institute of Genetics & Animal Biotechnology, Polish Academy of
   Sciences; Polish Academy of Sciences; Chinese Academy of Sciences;
   University of Science & Technology of China, CAS; Guizhou University of
   Traditional Chinese Medicine; Medical University of Vienna; University
   of Vienna; Bulgarian Academy of Sciences
RP Wang, DD (corresponding author), McMaster Univ, Ctr Metab Obes & Diabet Res, 1280 Main St W, Hamilton, ON L8N 3Z5, Canada.; Atanasov, AG (corresponding author), Polish Acad Sci, Dept Biotechnol & Nutrigen, Inst Genet & Anim Biotechnol, PL-05552 Jastrzebiec, Poland.
EM wangd123@mcmaster.ca; atanas.atanasov@univie.ac.at
RI Horbanczuk, Jaroslaw/ABD-8389-2021; Xu, Suowen/H-8697-2019; Tewari,
   Devesh/P-9954-2019; Wang, Dongdong/P-7257-2016; Atanasov,
   Atanas/C-5535-2013
OI Wang, Dongdong/0000-0002-6195-4428; Atanasov,
   Atanas/0000-0003-2545-0967; Horbanczuk, Jaroslaw
   Olav/0000-0002-7561-0941; Xu, Suowen/0000-0002-5488-5217
FU Cultivation project for clinical medicine of the integrated traditional
   Chinese and western medicine; Cultivation project for education team of
   internal medicine of the integrated traditional Chinese and western
   medicine; first-class universities in Guizhou province [2017-158]
FX This work was supported by the Cultivation project for clinical medicine
   of the integrated traditional Chinese and western medicine and
   Cultivation project for education team of internal medicine of the
   integrated traditional Chinese and western medicine in the first-term
   subjects with special support in the first-class universities in Guizhou
   province (Qin Jiao Gao Fa No. 2017-158).
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NR 113
TC 40
Z9 41
U1 9
U2 55
PU ELSEVIER SCIENCE LONDON
PI LONDON
PA 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND
SN 0924-2244
EI 1879-3053
J9 TRENDS FOOD SCI TECH
JI Trends Food Sci. Technol.
PD NOV
PY 2021
VL 117
BP 34
EP 45
DI 10.1016/j.tifs.2020.11.024
EA NOV 2021
PG 12
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA YV4WQ
UT WOS:000752730600004
DA 2025-06-11
ER

PT J
AU Jarhahzadeh, M
   Alavinejad, P
   Farsi, F
   Husain, D
   Rezazadeh, A
AF Jarhahzadeh, Maryam
   Alavinejad, Pezhman
   Farsi, Farnaz
   Husain, Durdana
   Rezazadeh, Afshin
TI The effect of turmeric on lipid profile, malondialdehyde, liver
   echogenicity and enzymes among patients with nonalcoholic fatty liver
   disease: a randomized double blind clinical trial
SO DIABETOLOGY & METABOLIC SYNDROME
LA English
DT Article
DE Turmeric; NAFLD; Liver transaminases; Metabolic syndrome; Curcumin
ID FACTOR-KAPPA-B; INSULIN-RESISTANCE; TRANSCRIPTION FACTOR; OXIDATIVE
   STRESS; CURCUMIN; ANTIOXIDANT; SUPPLEMENTATION; PATHOGENESIS;
   ACTIVATION; METAANALYSIS
AB Background Nonalcoholic fatty liver disease (NAFLD) is one of the most common causes of liver transaminases elevation and a global health concern. Purpose This study designed to evaluate the effects of turmeric rhizomes (Curcumalonga Linn.) on liver enzymes, Lipid profiles and Malondialdehyde (MDA) in patients with NAFLD. Study design Randomized double-blind placebo controlled trial. Methods 64 cases of NAFLD randomly assigned to receive either turmeric (2 gr/day) or placebo for 8 weeks. The changes of liver transaminases, lipid profiles and MDA were measured before and after study period and compared between two groups (IRCT 2015092924262N1). Results At the end of the study, the Turmeric group showed a significant reduction in liver enzymes (AST before 26.81 +/- 10.54 after 21.19 +/- 5.67, P = 0.044, ALT before 39.56 +/- 22.41, after 30.51 +/- 12.61, P = 0.043 and GGT before33.81 +/- 17.50, after 25.62 +/- 9.88, P = 0.046) compared with the placebo group. The serum levels of triglycerides, LDL, HDL and MDA had also a significant decrease among turmeric group as compared to baseline while there was no significant change in placebo group (P < 0.05). The serum cholesterol, VLDL level and sonographic grades of NAFLD had not any significant change in both groups. Conclusion In conclusion this study suggests that daily consumption of turmeric (and its active phenolic ingredients as curcumin) supplementation could be effective in management of NAFLD and decreasing serum level of liver transaminases.
C1 [Jarhahzadeh, Maryam] Ahvaz Jundishapur Univ Med Sci, Fac Paramed, Dept Nutr, Ahvaz, Iran.
   [Alavinejad, Pezhman] Ahvaz Jundishapur Univ Med Sci, Alimentary Tract Res Ctr, Azadegan Ave, Ahvaz, Iran.
   [Farsi, Farnaz] Iran Univ Med Sci, Colorectal Res Ctr, Tehran, Iran.
   [Husain, Durdana] Ahvaz Jundishapur Univ Med Sci, Sch Paramed, Dept Nutr, Ahvaz, Iran.
   [Rezazadeh, Afshin] Ahvaz Jundishapur Univ Med Sci, Fac Med, Ahvaz, Iran.
C3 Ahvaz Jundishapur University of Medical Sciences (AJUMS); Ahvaz
   Jundishapur University of Medical Sciences (AJUMS); Iran University of
   Medical Sciences; Ahvaz Jundishapur University of Medical Sciences
   (AJUMS); Ahvaz Jundishapur University of Medical Sciences (AJUMS)
RP Alavinejad, P (corresponding author), Ahvaz Jundishapur Univ Med Sci, Alimentary Tract Res Ctr, Azadegan Ave, Ahvaz, Iran.
EM pezhmanalavinejad@gmail.com
RI Rezazadeh, Afshin/AIC-4284-2022; Alavinejad, Pezhman/AAD-2742-2020
OI Rezazadeh, Afshin/0000-0001-8980-5777; Alavinejad,
   Pezhman/0000-0001-6857-6151
FU Alimentary Tract Research Center of Ahvaz Jundishapur University of
   Medical Sciences
FX This work was supported by Alimentary Tract Research Center of Ahvaz
   Jundishapur University of Medical Sciences without any financial grant.
   This research did not receive any specific grant from funding agencies
   in the public, commercial, or not-for-profit sectors.
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NR 66
TC 31
Z9 32
U1 7
U2 23
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1758-5996
J9 DIABETOL METAB SYNDR
JI Diabetol. Metab. Syndr.
PD OCT 18
PY 2021
VL 13
IS 1
AR 112
DI 10.1186/s13098-021-00731-7
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA WI6KT
UT WOS:000708467600003
PM 34663438
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Zheng, Q
   Li, S
   Li, XJY
   Liu, RP
AF Zheng, Qi
   Li, Shuo
   Li, Xiaojiaoyang
   Liu, Runping
TI Advances in the study of emodin: an update on pharmacological properties
   and mechanistic basis
SO CHINESE MEDICINE
LA English
DT Review
DE Emodin; Pharmacology; Toxicology; Pharmacokinetics; Modification
ID EPITHELIAL-MESENCHYMAL TRANSITION; ENDOPLASMIC-RETICULUM STRESS;
   ENDOTHELIAL GROWTH-FACTOR; SEVERE ACUTE-PANCREATITIS; TUMOR-SUPPRESSOR
   GENES; MAIN COMPONENT EMODIN; CERVICAL-CANCER CELLS; ACUTE LUNG INJURY;
   IN-VITRO; AIRWAY INFLAMMATION
AB Rhei Radix et Rhizoma, also known as rhubarb or Da Huang, has been widely used as a spice and as traditional herbal medicine for centuries, and is currently marketed in China as the principal herbs in various prescriptions, such as Da-Huang-Zhe-Chong pills and Da-Huang-Qing-Wei pills. Emodin, a major bioactive anthraquinone derivative extracted from rhubarb, represents multiple health benefits in the treatment of a host of diseases, such as immune-inflammatory abnormality, tumor progression, bacterial or viral infections, and metabolic syndrome. Emerging evidence has made great strides in clarifying the multi-targeting therapeutic mechanisms underlying the efficacious therapeutic potential of emodin, including anti-inflammatory, immunomodulatory, anti-fibrosis, anti-tumor, anti-viral, anti-bacterial, and anti-diabetic properties. This comprehensive review aims to provide an updated summary of recent developments on these pharmacological efficacies and molecular mechanisms of emodin, with a focus on the underlying molecular targets and signaling networks. We also reviewed recent attempts to improve the pharmacokinetic properties and biological activities of emodin by structural modification and novel material-based targeted delivery. In conclusion, emodin still has great potential to become promising therapeutic options to immune and inflammation abnormality, organ fibrosis, common malignancy, pathogenic bacteria or virus infections, and endocrine disease or disorder. Scientifically addressing concerns regarding the poor bioavailability and vague molecular targets would significantly contribute to the widespread acceptance of rhubarb not only as a dietary supplement in food flavorings and colorings but also as a health-promoting TCM in the coming years.
C1 [Zheng, Qi; Li, Shuo; Liu, Runping] Beijing Univ Chinese Med, Sch Chinese Mat Med, 11 Bei San Huan Dong Lu, Beijing 100029, Peoples R China.
   [Li, Xiaojiaoyang] Beijing Univ Chinese Med, Sch Life Sci, 11 Bei San Huan Dong Lu, Beijing 100029, Peoples R China.
C3 Beijing University of Chinese Medicine; Beijing University of Chinese
   Medicine
RP Liu, RP (corresponding author), Beijing Univ Chinese Med, Sch Chinese Mat Med, 11 Bei San Huan Dong Lu, Beijing 100029, Peoples R China.
EM liurunping@bucm.edu.cn
RI liu, runping/V-2733-2018; qi, zheng/KYP-5955-2024; Li,
   Xiaojiaoyang/CAG-6603-2022
FU National Natural Science Foundation of China [82004029]; Beijing Nova
   Program of Science Technology [Z201100006820025]; Beijing University of
   Chinese Medicine [2020-JYB-ZDGG-038]
FX This work was supported by the National Natural Science Foundation of
   China (Grant Number 82004029); Beijing Nova Program of Science &
   Technology (Grant Number Z201100006820025); and Beijing University of
   Chinese Medicine (Grant Number 2020-JYB-ZDGG-038).
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NR 222
TC 57
Z9 62
U1 7
U2 106
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1749-8546
J9 CHIN MED-UK
JI Chin. Med.
PD OCT 10
PY 2021
VL 16
IS 1
AR 102
DI 10.1186/s13020-021-00509-z
PG 24
WC Integrative & Complementary Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine; Pharmacology & Pharmacy
GA WE1WX
UT WOS:000705418900001
PM 34629100
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Wei, DD
   Hou, J
   Liu, X
   Zhang, LY
   Wang, LL
   Liu, PL
   Fan, KL
   Zhang, L
   Nie, LT
   Xu, QQ
   Wang, J
   Song, Y
   Wang, MA
   Liu, XT
   Huo, WQ
   Yu, SC
   Li, LL
   Jing, T
   Wang, CJ
   Mao, ZX
AF Wei, Dandan
   Hou, Jian
   Liu, Xue
   Zhang, Liying
   Wang, Lulu
   Liu, Pengling
   Fan, Keliang
   Zhang, Li
   Nie, Luting
   Xu, Qingqing
   Wang, Juan
   Song, Yu
   Wang, Mian
   Liu, Xiaotian
   Huo, Wenqian
   Yu, Songcheng
   Li, Linlin
   Jing, Tao
   Wang, Chongjian
   Mao, Zhenxing
TI Interaction between testosterone and obesity on hypertension: A
   population-based cross-sectional study
SO ATHEROSCLEROSIS
LA English
DT Article
DE Testosterone; Hypertension; Obesity; Interactive effect
ID HORMONE-BINDING GLOBULIN; OXIDATIVE STRESS; METABOLIC SYNDROME;
   BLOOD-PRESSURE; SEX-HORMONES; ENDOGENOUS TESTOSTERONE; POSTMENOPAUSAL
   WOMEN; CARDIOVASCULAR RISK; INSULIN-RESISTANCE; MEN
AB Background and aims: We aimed to evaluate the effects of serum testosterone, obesity and their interaction on blood pressure (BP) parameters and hypertension among Chinese rural adults. Methods: A total of 6199 adults were recruited from the Henan Rural Cohort Study. Serum testosterone was measured by liquid chromatography-tandem mass spectrometry. Logistic regression and linear regression were used to evaluate the association between testosterone, hypertension and BP parameters (including systolic blood pressure (SBP), diastolic blood pressure (DBP), pulse pressure (PP), and mean arterial pressure (MAP)). A generalized linear model was performed to identify the interactive effects of testosterone and obesity on hypertension. Results: High levels of serum testosterone were associated with a lower prevalence of hypertension in males (odds ratio (OR): 0.69, 95% confidence interval (CI): 0.53, 0.89). After stratification by obesity, observed associations were only found in non-obese males. Each one-unit increase in ln-testosterone was associated with a 1.23 mmHg decrease in SBP, 0.97 mmHg decrease in DBP, and 1.05 mmHg decrease in MAP among males. Moreover, interactive effects between testosterone and obesity on hypertension and BP parameters were found, indicating that protective effects of serum testosterone on hypertension and BP parameters were counteracted and accompanied by increased values of obesity-related indicators in males, and additional testosterone increased BP parameters and prevalence of hypertension at high levels of waist-to-hip ratio and waist-to-height ratio in females. Conclusions: Elevated levels of serum testosterone were associated with decreased BP parameters and prevalent hypertension in males, and obesity modifying effects of serum testosterone on BP parameters and hypertension.
C1 [Wei, Dandan; Hou, Jian; Liu, Xue; Zhang, Liying; Wang, Lulu; Liu, Pengling; Fan, Keliang; Zhang, Li; Xu, Qingqing; Wang, Juan; Liu, Xiaotian; Li, Linlin; Wang, Chongjian; Mao, Zhenxing] Zhengzhou Univ, Coll Publ Hlth, Dept Epidemiol & Biostat, 100 Kexue Ave, Zhengzhou 450001, Henan, Peoples R China.
   [Nie, Luting; Song, Yu; Wang, Mian; Huo, Wenqian] Zhengzhou Univ, Coll Publ Hlth, Dept Occupat & Environm Hlth Sci, Zhengzhou, Henan, Peoples R China.
   [Yu, Songcheng] Zhengzhou Univ, Coll Publ Hlth, Dept Nutr & Food Hyg, Zhengzhou, Henan, Peoples R China.
   [Zhang, Liying] Zhengzhou Univ, Sch Informat Engn, Zhengzhou, Henan, Peoples R China.
   [Jing, Tao] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Wuhan, Hubei, Peoples R China.
C3 Zhengzhou University; Zhengzhou University; Zhengzhou University;
   Zhengzhou University; Huazhong University of Science & Technology
RP Mao, ZX (corresponding author), Zhengzhou Univ, Coll Publ Hlth, Dept Epidemiol & Biostat, 100 Kexue Ave, Zhengzhou 450001, Henan, Peoples R China.
EM maozhr@gmail.com
RI Jing, Tao/V-8255-2019; zhang, liying/W-5447-2019; Cheng,
   Si/JDW-6131-2023; huo, wenqian/O-1974-2013; Wang, Mian/K-1299-2019
OI Huo, Wenqian/0000-0002-7898-093X; Wang, Chongjian/0000-0001-5091-6621
FU National Key Research and Development Program of China [2019YFC1710002,
   2016YFC0900803]; National Natural Science Foundation of China [21607136,
   21806146]; Postdoctoral Science Foundation of China [2016M602264,
   2020T130604]; Excellent Youth Development Foundation of Zhengzhou
   University [2018ZDGGJS052]; Science and Technique Foundation of Henan
   Province [202102310046]
FX This research was supported by the National Key Research and Development
   Program of China (Grant NO: 2019YFC1710002, 2016YFC0900803) , the
   National Natural Science Foundation of China (Grant NO: 21607136,
   21806146) , the Postdoctoral Science Foundation of China (Grant NO:
   2016M602264, 2020T130604) , the Excellent Youth Development Foundation
   of Zhengzhou University (Grant NO: 2018ZDGGJS052) , and the Science and
   Technique Foundation of Henan Province (Grant NO: 202102310046) . The
   authors declare that they have no known competing financial interests or
   personal relationships that could have appeared to influence the work
   reported in this paper. The authors thank the participants,
   coordinators, and administrators for their supports, and laboratory for
   the facility support at the school of Public Health, Zhengzhou
   University, during the study.
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NR 49
TC 16
Z9 19
U1 1
U2 22
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0021-9150
EI 1879-1484
J9 ATHEROSCLEROSIS
JI Atherosclerosis
PD AUG
PY 2021
VL 330
BP 14
EP 21
DI 10.1016/j.atherosclerosis.2021.06.906
EA JUL 2021
PG 8
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA TS2HP
UT WOS:000679477100003
PM 34218213
DA 2025-06-11
ER

PT J
AU Gorabi, AM
   Razi, B
   Aslani, S
   Abbasifard, M
   Imani, D
   Sathyapalan, T
   Sahebkar, A
AF Gorabi, Armita Mahdavi
   Razi, Bahman
   Aslani, Saeed
   Abbasifard, Mitra
   Imani, Danyal
   Sathyapalan, Thozhukat
   Sahebkar, Amirhossein
TI Effect of curcumin on proinflammatory cytokines: A meta-analysis of
   randomized controlled trials
SO CYTOKINE
LA English
DT Review
DE Curcumin; Inflammation; Randomized controlled trials; Interleukin; TNF
ID KAPPA-B ACTIVATION; OXIDATIVE STRESS; DOUBLE-BLIND; INFLAMMATORY
   CYTOKINES; METABOLIC SYNDROME; PLACEBO; DISEASE; SUPPLEMENTATION;
   INTERLEUKIN-6; OVERWEIGHT
AB It has been suggested that curcumin has the potential for lowering inflammation. In the current meta-analysis, we attempted to clarify the efficacy of curcumin/turmeric supplementation in reducing concentrations of interleukin (IL)-1, IL-6, IL-8, and tumor necrosis factor (TNF)-alpha in patients with an inflammatory background. The main databases were searched to identify eligible trials evaluating the effect of curcumin in reducing IL-1, IL-6, IL-8, and TNF-alpha in serum up to March 2021. The effect sizes for weighted mean difference (WMD) and 95% confidence intervals (CI) were calculated. Overall, 32 randomized controlled trials (RCTs) were included. There was a significant decrease in the serum levels of IL-1 (WMD =-2.33 pg/ml, 95% CI =-3.33 to-1.34, P < 0.001) and TNF-alpha (WMD =-1.61 pg/ml, 95% CI =-2.72,-0.51, P < 0.001) compared to the placebo group following treatment. Nonetheless, curcumin/turmeric supplementation was non-significantly associated with reduced levels of IL-6 (WMD =-0.33 pg/ml, 95% CI = -0.99-0.34, P = 0.33) and increased levels of IL-8 (WMD = 0.52 pg/ml, 95% CI = -1.13-2.17, P = 0.53). The dose-responses analysis indicated that curcumin/turmeric sup-plementation resulted in IL-1 and IL-8 alteration in a non-linear model. Subgroup analysis according to duration and dose of treatment and target population revealed diverse outcomes. Curcumin could have a beneficial effect in reducing the proinflammatory cytokines IL-1 and TNF-alpha, but not IL-6 and IL-8 levels.
C1 [Gorabi, Armita Mahdavi] Univ Tehran Med Sci, Res Ctr Adv Technol Cardiovasc Med, Tehran Heart Ctr, Tehran, Iran.
   [Razi, Bahman] Tarbiat Modares Univ, Sch Med, Dept Hematol & Blood Transfus, Tehran, Iran.
   [Aslani, Saeed] Univ Tehran Med Sci, Sch Med, Dept Immunol, Tehran, Iran.
   [Abbasifard, Mitra] Rafsanjan Univ Med Sci, Mol Med Res Ctr, Res Inst Basic Med Sci, Rafsanjan, Iran.
   [Abbasifard, Mitra] Rafsanjan Univ Med Sci, Ali Ibn Abi Talib Hosp, Sch Med, Dept Internal Med, Rafsanjan, Iran.
   [Imani, Danyal] Univ Tehran Med Sci, Sch Publ Hlth, Dept Immunol, Enghelab Av, Tehran, Iran.
   [Sathyapalan, Thozhukat] Univ Hull, Acad Diabet Endocrinol & Metab, Hull York Med Sch, Kingston Upon Hull, N Humberside, England.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Appl Biomed Res Ctr, Mashhad, Razavi Khorasan, Iran.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Biotechnol Res Ctr, Pharmaceut Technol Inst, Mashhad, Razavi Khorasan, Iran.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Sch Pharm, Mashhad, Razavi Khorasan, Iran.
C3 Tehran University of Medical Sciences; Tarbiat Modares University;
   Tehran University of Medical Sciences; Tehran University of Medical
   Sciences; University of Hull; University of York - UK; Mashhad
   University of Medical Sciences; Mashhad University of Medical Sciences;
   Mashhad University of Medical Sciences
RP Imani, D; Sahebkar, A (corresponding author), Univ Tehran Med Sci, Sch Publ Hlth, Dept Immunol, Enghelab Av, Tehran, Iran.; Imani, D; Sahebkar, A (corresponding author), Mashhad Univ Med Sci, Sch Med, Dept Med Biotechnol, Mashhad, Razavi Khorasan, Iran.
EM sahebkara@mums.ac.ir
RI Abbasifard, mitra/I-1595-2017; Razi, Bahman/HCI-8979-2022; Sathyapalan,
   Thozhukat/J-5212-2012; Sahebkar, Amirhossein/B-5124-2018; Aslani,
   Saeed/AAV-6835-2020
OI Abbasifard, Mitra/0000-0001-8149-8549; Sathyapalan,
   Thozhukat/0000-0003-3544-2231
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NR 57
TC 47
Z9 47
U1 1
U2 13
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 1043-4666
EI 1096-0023
J9 CYTOKINE
JI Cytokine
PD JUL
PY 2021
VL 143
AR 155541
DI 10.1016/j.cyto.2021.155541
EA MAY 2021
PG 13
WC Biochemistry & Molecular Biology; Cell Biology; Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology; Immunology
GA SD2TI
UT WOS:000651224100002
PM 33934954
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Joo, HW
   Song, YS
   Park, IH
   Shen, GY
   Seong, JH
   Shin, NK
   Lee, AH
   Kim, H
   Kim, KS
AF Joo, Hyun-Woo
   Song, Yi-Sun
   Park, In-Hwa
   Shen, Guang-Yin
   Seong, Jin-Hee
   Shin, Na-Kyoung
   Lee, A-Hyeon
   Kim, Hyuck
   Kim, Kyung-Soo
TI Granulocyte Colony Stimulating Factor Ameliorates Hepatic Steatosis
   Associated with Improvement of Autophagy in Diabetic Rats
SO CANADIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
LA English
DT Article
ID FATTY LIVER-DISEASE; METABOLIC SYNDROME; LIPOPHAGY; PREVENTS; STRESS;
   RISK
AB Background. We previously reported that the granulocyte colony stimulating factor (G-CSF) ameliorated hepatic steatosis with the enhancement of beta-oxidation-related gene expression. However, the mechanisms underlying this process remain unclear. This study aimed to determine whether the improvement of hepatic steatosis by G-CSF was associated with autophagy in a rat model of diabetes.Methods. Eight rats were fed a standard diet, and 16 rats were fed high-fat diet (HFD) for 5 weeks. All HFD-fed rats were then injected with streptozotocin (STZ). One week later, HFD rats injected with STZ were randomly treated with either G-CSF (200 mu g/kg/day; diabetes mellitus (DM)/G-CSF) or saline (DM/saline) for 5 consecutive days. Four weeks later, serum biochemical and histology analyses were conducted. The expression of autophagy-associated proteins was determined by Western blotting. The mRNA expression of beta-oxidation-related genes was determined by quantitative real-time polymerase chain reaction. HepG2 cells were cultured under high glucose (HG) conditions with G-CSF treatment, followed by Oil Red O staining for quantification of lipids.Results. Histological analysis showed lower lipid accumulation in the DM/G-CSF group than in the DM/saline-treated rats. Protein levels of LC3 and beclin-1 were higher, and those of p62 were lower in the DM/G-CSF rats than in the DM/saline-treated rats. The mRNA expression of beta-oxidation-related genes was higher in DM/G-CSF rats than in the DM/saline-treated rats. Quantification of lipid levels in HepG2 cells cultured with HG and G-CSF treatment revealed no significant differences.Conclusions. Our data suggested that G-CSF potentially improves hepatic steatosis and autophagy in the liver of diabetic rats.
C1 [Joo, Hyun-Woo; Song, Yi-Sun; Park, In-Hwa; Seong, Jin-Hee; Shin, Na-Kyoung; Lee, A-Hyeon; Kim, Kyung-Soo] Hanyang Univ, Grad Sch Biomed Sci & Engn, Seoul, South Korea.
   [Shen, Guang-Yin; Kim, Kyung-Soo] Hanyang Univ, Dept Internal Med, Coll Med, Seoul, South Korea.
   [Shen, Guang-Yin] Jilin Univ, Dept Cardiol, Jilin Cent Hosp, Jilin, Jilin, Peoples R China.
   [Kim, Hyuck] Hanyang Univ, Dept Thorac & Cardiovasc Surg, Coll Med, Seoul, South Korea.
C3 Hanyang University; Hanyang University; Jilin University; Hanyang
   University
RP Kim, KS (corresponding author), Hanyang Univ, Grad Sch Biomed Sci & Engn, Seoul, South Korea.; Kim, KS (corresponding author), Hanyang Univ, Dept Internal Med, Coll Med, Seoul, South Korea.
EM kskim@hanyang.ac.kr
RI Kim, Yong-Joo/AAK-1840-2021; Shin, Sun/B-7370-2009
OI Lee, A-Hyeon/0000-0002-5422-6107
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NR 36
TC 3
Z9 3
U1 0
U2 1
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2291-2789
EI 2291-2797
J9 CAN J GASTROENTEROL
JI Can. J. Gastroenterol. Hepatol.
PD JUL 25
PY 2020
VL 2020
AR 2156829
DI 10.1155/2020/2156829
PG 9
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA MZ6SR
UT WOS:000559259600001
PM 32775312
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Singh, MK
   Dwivedi, S
   Yadav, SS
   Yadav, RS
   Khattri, S
AF Singh, Manish Kumar
   Dwivedi, Shailendra
   Yadav, Suraj Singh
   Yadav, Rajesh Singh
   Khattri, Sanjay
TI Anti-diabetic Effect of Emblica-officinalis (Amla) Against
   Arsenic Induced Metabolic Disorder in Mice
SO INDIAN JOURNAL OF CLINICAL BIOCHEMISTRY
LA English
DT Article
DE Arsenic; Amla; Hyperglycemic; Inflammation; Mice; Metabolic syndrome
ID DIABETES PREVALENCE; DISEASE PREVENTION; EXPOSURE; GLUCOSE; TOXICITY;
   EFFICACY; HEART
AB Chronic exposure to arsenic through drinking water and occupational exposure has been found to be associated with the diabetic symptoms. Earlier, we reported that arsenic induced enhanced oxidative stress, inflammation, dislipidemia and hepatotoxicity in mice have been protected by treatment with Emblica officinalis (amla). The present study has therefore been focused to investigate the efficacy of amla in mitigation of arsenic induced hyperglycemia in mice. Arsenic exposure (3 mg/kg b.w./day for 30 days) in mice altered glucose homeostasis and significantly decreases hepatic glucose regulatory enzyme, glucokinase (43%), glucose-6 phosphate dehydrogenase (38%), malic enzyme (60%) and significantly increases the level of glucose-6 phosphates (65%), phosphoenolpyruvate carboxykinase (43%), lactate, (59%) Na+ (6.8%) Cl- (10.4%), anion gap (13.9%) and pancreatic (IL-1 beta, TNF-alpha) inflammation markers (52%, 53%) as compared to controls. Arsenic exposure also significantly decreased serum insulin (44%) and c-peptide protein (38%) in mice as compared to controls. Co-administration of arsenic and amla (500 mg/kg b.w./day for 30 days) balanced blood sugar level, hepatic glucose regulatory enzyme (glucokinase, glucose-6 phosphate dehydrogenase, malic enzyme (68%, 37%, 45%) and significantly decreases glucose-6 phosphatase (25%), phosphoenolpyruvate carboxykinase (22%), blood ion concentration and also lactate, Na+, Cl- and anion gap (20%, 4.6%, 6.7%, 5.2%), pancreatic (IL-1 beta, TNF-alpha) inflammation marker (21%, 24%) and significantly increased the serum insulin (57%) and c-peptide protein (31%) as compared to those treated with arsenic alone. Results of the present study suggests that the hypoglycemic and antioxidant property of amla could be responsible for its protective efficacy in arsenic induced hyperglycemia.
C1 [Singh, Manish Kumar] Govt Med Coll Badaun, Dept Biochem, Badaun 243601, UP, India.
   [Dwivedi, Shailendra] All India Inst Med Sci, Dept Biochem, Jodhpur 342005, Rajasthan, India.
   [Yadav, Suraj Singh; Khattri, Sanjay] King Georges Med Univ, Dept Pharmacol & Therapeut, Lucknow 226003, Uttar Pradesh, India.
   [Yadav, Rajesh Singh] Dr Hari Singh Gour Vishwavidyalaya, Dept Criminol & Forens Sci, Sagar 470003, MP, India.
C3 All India Institute of Medical Sciences (AIIMS) Jodhpur; King George's
   Medical University; Dr. Hari Singh Gour University
RP Khattri, S (corresponding author), King Georges Med Univ, Dept Pharmacol & Therapeut, Lucknow 226003, Uttar Pradesh, India.
EM pharmacsmu@gmail.com
RI Dwivedi, Shailendra/H-9335-2019; Yadav, Suraj Singh/AGI-1700-2022
OI Yadav, Suraj Singh/0000-0002-3482-9664; Dwivedi,
   Shailendra/0000-0003-2781-1009; Yadav, Rajesh/0000-0002-1754-6187
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NR 38
TC 17
Z9 18
U1 0
U2 7
PU SPRINGER INDIA
PI NEW DELHI
PA 7TH FLOOR, VIJAYA BUILDING, 17, BARAKHAMBA ROAD, NEW DELHI, 110 001,
   INDIA
SN 0970-1915
EI 0974-0422
J9 INDIAN J CLIN BIOCHE
JI Indian J. Clin. Biochem.
PD APR
PY 2020
VL 35
IS 2
BP 179
EP 187
DI 10.1007/s12291-019-00820-5
PG 9
WC Biochemistry & Molecular Biology
WE Emerging Sources Citation Index (ESCI)
SC Biochemistry & Molecular Biology
GA LC7WO
UT WOS:000525544100006
PM 32226249
OA Green Published
DA 2025-06-11
ER

PT J
AU Martini, L
   Pecoraro, L
   Salvottini, C
   Piacentini, G
   Atkinson, R
   Pietrobelli, A
AF Martini, Lucia
   Pecoraro, Luca
   Salvottini, Chiara
   Piacentini, Giorgio
   Atkinson, Richard
   Pietrobelli, Angelo
TI Appropriate and inappropriate vitamin supplementation in children
SO JOURNAL OF NUTRITIONAL SCIENCE
LA English
DT Review
DE Vitamin A; Vitamin D; Vitamin E; Vitamin B; Folic acid; Vitamin C;
   Children
ID INSULIN-RESISTANCE; ESPGHAN COMMITTEE; C SUPPLEMENTATION; A
   SUPPLEMENTATION; OXIDATIVE STRESS; POSITION PAPER; LIPID PROFILE;
   FOLIC-ACID; DEFICIENCY; PREVENTION
AB The vitamin status of a child depends on many factors and most of the clinical studies do not take into account the different access to adequate nutrition of children coming from different countries and the consequent major differences in micronutrients or vitamin deficits between low-income and high-income countries. Vitamin supplements are included in the general field of dietary supplements. There is a large amount of not always factual material concerning vitamin supplements, and this may sometimes create confusion in clinicians and patients. Inadequate information may lead to the risk of attributing beneficial properties leading to their over-use or misuse in the paediatric field. Vitamin supplementation is indicated in all those conditions in which a vitamin deficiency is found, either because of a reduced intake due to reduced availability of certain foods, restrictive diets or inadequate absorption. The lack of guidelines in these fields may lead paediatricians to an improper use of vitamins, both in terms of excessive use or inadequate use. This is due to the fact that vitamin supplementation is often intended as a therapy of support rather than an essential therapeutic tool able to modify disease prognosis. In fact, various vitamins and their derivatives have therapeutic potential in the prevention and treatment of many diseases, especially in emerging conditions of paediatric age such as type 2 diabetes and the metabolic syndrome. The aim of the present article is to analyse the state of the art and consider new perspectives on the role of vitamin supplements in children.
C1 [Martini, Lucia; Pecoraro, Luca; Salvottini, Chiara; Piacentini, Giorgio; Pietrobelli, Angelo] Univ Verona, Dept Surg Sci Dent Gynecol & Pediat, Pediat Clin, Verona, Italy.
   [Atkinson, Richard] Virginia Commonwealth Univ, Dept Internal Med, Richmond, VA USA.
   [Pietrobelli, Angelo] Pennington Biomed Res Ctr, 6400 Perkins Rd, Baton Rouge, LA 70808 USA.
C3 University of Verona; Virginia Commonwealth University; Louisiana State
   University System; Louisiana State University; Pennington Biomedical
   Research Center
RP Pecoraro, L (corresponding author), Univ Verona, Dept Surg Sci Dent Gynecol & Pediat, Pediat Clin, Verona, Italy.
EM lucapecoraro88@gmail.com
RI Atkinson, Richard/AAK-4953-2021; Pecoraro, Luca/GLS-6559-2022
OI Pecoraro, Luca/0000-0002-9765-8006; PIACENTINI,
   Giorgio/0000-0003-1324-4373
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NR 72
TC 23
Z9 23
U1 0
U2 11
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 2048-6790
J9 J NUTR SCI
JI J. Nutr. Sci.
PY 2020
VL 9
AR e20
DI 10.1017/jns.2020.12
PG 8
WC Nutrition & Dietetics
WE Emerging Sources Citation Index (ESCI)
SC Nutrition & Dietetics
GA LU4VI
UT WOS:000537754600001
PM 32577225
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Le, JM
   Zhang, XY
   Jia, WP
   Zhang, Y
   Luo, JT
   Sun, YN
   Ye, JP
AF Le, Jiamei
   Zhang, Xiaoying
   Jia, Weiping
   Zhang, Yong
   Luo, Juntao
   Sun, Yongning
   Ye, Jianping
TI Regulation of microbiota-GLP1 axis by sennoside A in diet-induced obese
   mice
SO ACTA PHARMACEUTICA SINICA B
LA English
DT Article
DE Sennoside A; Insulin sensitivity; Mitochondria; Gut microbiota; Short
   chain fatty acids; GLP1
ID CHAIN FATTY-ACIDS; GUT MICROBIOTA; INSULIN SENSITIVITY; METABOLIC
   SYNDROME; LARGE-INTESTINE; BODY-WEIGHT; IN-VITRO; MECHANISMS;
   RESISTANCE; PHYSIOLOGY
AB Sennoside A (SA) is a bioactive component of Chinese herbal medicines with an activity of irritant laxative, which is often used in the treatment of constipation and obesity. However, its activity remains unknown in the regulation of insulin sensitivity. In this study, the impact of SA on insulin sensitivity was tested in high fat diet (HFD)-induced obese mice through dietary supplementation. At a dosage of 30 mg/kg/day, SA improved insulin sensitivity in the mice after 8-week treatment as indicated by HOMA-IR (homeostatic model assessment for insulin resistance) and glucose tolerance test (GTT). SA restored plasma level of glucagon-like peptide 1 (GLP1) by 90% and mRNA expression of Glpl by 80% in the large intestine of HFD mice. In the mechanism, SA restored the gut microbiota profile, short chain fatty acids (SCFAs), and mucosal structure in the colon. A mitochondrial stress was observed in the enterocytes of HFD mice with ATP elevation, structural damage, and complex dysfunction. The mitochondrial response was induced in enterocytes by the dietary fat as the same responses were induced by palmitic acid in the cell culture. The mitochondrial response was inhibited in HFD mice by SA treatment. These data suggest that SA may restore the function of microbiota GLP1 axis to improve glucose metabolism in the obese mice. (C) 2019 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.
C1 [Le, Jiamei] Shanghai Univ Med & Hlth Sci, Shanghai Key Lab Mol Imaging, Shanghai 201318, Peoples R China.
   [Le, Jiamei; Sun, Yongning] Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Dept Tradit Chinese Med, Shanghai 200233, Peoples R China.
   [Zhang, Xiaoying; Luo, Juntao; Ye, Jianping] Shanghai Jiao Tong Univ, Affiliated Peoples Hosp East 6, Cent Lab, Shanghai 201306, Peoples R China.
   [Jia, Weiping; Ye, Jianping] Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Diabet Inst, Shanghai 200233, Peoples R China.
   [Zhang, Yong; Ye, Jianping] LSU, Pennington Biomed Res Ctr, Antioxidant & Gene Regulat Lab, Baton Rouge, LA 70808 USA.
   [Sun, Yongning] Shanghai Univ Tradit Chinese Med, Shanghai Municipal Hosp Tradit Chinese Med, Dept Cardiol, Shanghai 200071, Peoples R China.
C3 Shanghai University of Medicine & Health Sciences; Shanghai Jiao Tong
   University; Shanghai Jiao Tong University; Shanghai Jiao Tong
   University; Louisiana State University System; Louisiana State
   University; Pennington Biomedical Research Center; Shanghai University
   of Traditional Chinese Medicine
RP Sun, YN (corresponding author), Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Dept Tradit Chinese Med, Shanghai 200233, Peoples R China.; Ye, JP (corresponding author), Shanghai Jiao Tong Univ, Affiliated Peoples Hosp East 6, Cent Lab, Shanghai 201306, Peoples R China.; Ye, JP (corresponding author), Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Diabet Inst, Shanghai 200233, Peoples R China.; Ye, JP (corresponding author), LSU, Pennington Biomed Res Ctr, Antioxidant & Gene Regulat Lab, Baton Rouge, LA 70808 USA.; Sun, YN (corresponding author), Shanghai Univ Tradit Chinese Med, Shanghai Municipal Hosp Tradit Chinese Med, Dept Cardiol, Shanghai 200071, Peoples R China.
EM ynsun@sjtu.edu.cn; jianping.ye@pbrc.edu
RI Luo, Jun/JPX-3855-2023; Ye, Jianping/N-1998-2017; Jia,
   Weiping/B-7483-2012
OI Le, Jiamei/0000-0002-4776-1347; Ye, Jianping/0000-0003-3875-365X; Jia,
   Weiping/0000-0002-6244-2168
FU National Natural Science Foundation of China [81874377, 81220108006];
   internal fund of the Shanghai Jiaotong University Affiliated Sixth
   People's Hospital East (Shanghai, China)
FX The project was supported by the National Natural Science Foundation of
   China (81874377) to Yongning Sun and the National Natural Science
   Foundation of China (81220108006) to Weiping Jia and Jianping Ye. This
   study was also supported by the internal fund of the Shanghai Jiaotong
   University Affiliated Sixth People's Hospital East (Shanghai, China) to
   Jianping Ye and Yongning Sun.
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NR 44
TC 46
Z9 48
U1 2
U2 50
PU INST MATERIA MEDICA, CHINESE ACAD MEDICAL SCIENCES
PI BEIJING
PA C/O EDITORIAL BOARD OF ACTA PHARMACEUTICA SINICA, 1 XIANNONGTAN ST,
   BEIJING, 100050, PEOPLES R CHINA
SN 2211-3835
EI 2211-3843
J9 ACTA PHARM SIN B
JI Acta Pharm. Sin. B
PD JUL
PY 2019
VL 9
IS 4
BP 758
EP 768
DI 10.1016/j.apsb.2019.01.014
PG 11
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA IK6WT
UT WOS:000476730700009
PM 31384536
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Spallone, V
AF Spallone, Vincenza
TI Update on the Impact, Diagnosis and Management of Cardiovascular
   Autonomic Neuropathy in Diabetes: What Is Defined, What Is New, and What
   Is Unmet
SO DIABETES & METABOLISM JOURNAL
LA English
DT Review
DE Autonomic nervous system; Cardiovascular system; Diabetic neuropathies;
   Diagnosis; Epidemiology; Glucagon-like peptide-1 receptor; Hypotension;
   orthostatic; Prognosis; Sodium-glucose transporter 2 inhibitors;
   Therapeutics
ID HEART-RATE-VARIABILITY; ALPHA-LIPOIC ACID; IMPAIRED GLUCOSE-TOLERANCE;
   SYMPATHETIC-NERVOUS-SYSTEM; GLUCAGON-LIKE PEPTIDE-1; BLOOD-PRESSURE;
   ORTHOSTATIC HYPOTENSION; GLYCEMIC VARIABILITY; HYPERTENSIVE PATIENTS;
   METABOLIC SYNDROME
AB The burden of diabetic cardiovascular autonomic neuropathy (CAN) is expected to increase due to the diabetes epidemic and its early and widespread appearance. CAN has a definite prognostic role for mortality and cardiovascular morbidity. Putative mechanisms for this are tachycardia, QT interval prolongation, orthostatic hypotension, reverse dipping, and impaired heart rate variability, while emerging mechanisms like inflammation support the pervasiveness of autonomic dysfunction. Efforts to overcome CAN under-diagnosis are on the table: by promoting screening for symptoms and signs; by simplifying cardiovascular reflex tests; and by selecting the candidates for screening. CAN assessment allows for treatment of its manifestations, cardiovascular risk stratification, and tailoring therapeutic targets. Risk factors for CAN are mainly glycaemic control in type 1 diabetes mellitus (T1DM) and, in addition, hypertension, dyslipidaemia, and obesity in type 2 diabetes mellitus (T2DM), while preliminary data regard glycaemic variability, vitamin B-12 and D changes, oxidative stress, inflammation, and genetic biomarkers. Glycaemic control prevents CAN in T1DM, whereas multifactorial intervention might be effective in T2DM. Lifestyle intervention improves autonomic function mostly in pre-diabetes. While there is no conclusive evidence for a disease-modifying therapy, treatment of CAN manifestations is available. The modulation of autonomic function by SGLT2i represents a promising research field with possible clinical relevance.
C1 [Spallone, Vincenza] Univ Roma Tor Vergata, Div Endocrinol, Dept Syst Med, Via Montpellier 1, I-00133 Rome, Italy.
C3 University of Rome Tor Vergata
RP Spallone, V (corresponding author), Univ Roma Tor Vergata, Div Endocrinol, Dept Syst Med, Via Montpellier 1, I-00133 Rome, Italy.
EM vispa@mclink.it
RI SPALLONE, VINCENZA/AAF-7477-2019
OI SPALLONE, VINCENZA/0000-0002-8905-216X
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NR 170
TC 188
Z9 213
U1 0
U2 27
PU KOREAN DIABETES ASSOC
PI SEOUL
PA 101-2104, LOTTE CASTLE PRES, 109 MAPO-DAERO, MAPO-GU, SEOUL, 04146,
   SOUTH KOREA
SN 2233-6079
EI 2233-6087
J9 DIABETES METAB J
JI Diabetes Metab. J.
PD FEB
PY 2019
VL 43
IS 1
BP 3
EP 30
DI 10.4093/dmj.2018.0259
PG 28
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA HM3CB
UT WOS:000459349300002
PM 30793549
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Olaniyi, KS
   Olatunji, LA
AF Olaniyi, Kehinde Samuel
   Olatunji, Lawrence Aderemi
TI Oral ethinylestradiol-levonorgestrel attenuates cardiac glycogen and
   triglyceride accumulation in high fructose female rats by suppressing
   pyruvate dehydrogenase kinase-4
SO NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
LA English
DT Article
DE Cardiac dysfunction; Glycogen synthesis; Insulin resistance; Lipid
   accumulation; PDK-4; Metabolic syndrome
ID TYPE-2 DIABETES-MELLITUS; INSULIN-RESISTANCE; OXIDATIVE STRESS; RICH
   DIET; URIC-ACID; METABOLISM; HEART; CARDIOMYOPATHY; HYPERTROPHY;
   ANGIOTENSIN
AB Fructose (FRU) intake has increased dramatically in recent decades with a corresponding increased incidence of insulin resistance (IR), particularly in young adults. The use of oral ethinylestradiol-levonorgestrel (EEL) formulation is also common among young women worldwide. The present study aimed at determining the effect of EEL on high fructose-induced cardiac triglyceride (TG) and glycogen accumulation. The study also investigated the possible involvement of pyruvate dehydrogenase kinase-4 (PDK-4) in EEL and/or high fructose metabolic effects on the heart. Ten-week-old female Wistar rats were allotted into four groups. The control, EEL, FRU, and EEL + FRU rats received distilled water (vehicle, p.o.), 1.0g ethinylestradiol plus 5.0g levonorgestrel (p.o.), 10% fructose (w/v), and 1.0g ethinylestradiol plus 5.0g levonorgestrel and 10% fructose, respectively, daily for 8weeks. Data showed that EEL or high fructose caused IR, impaired glucose tolerance, hyperlipidemia, increased plasma lactate, lactate dehydrogenase, PDK-4, uric acid, xanthine oxidase (XO), adenosine deaminase (ADA), malondialdehyde (MDA), cardiac uric acid, TG, TG/HDL- cholesterol, glycogen synthesis, MDA, and visceral fat content and reduced glutathione. High fructose also resulted in impaired pancreatic -cell function, hyperglycemia, and increased cardiac PDK-4, lactate synthesis, and mass. Nonetheless, these alterations were ameliorated in EEL plus high fructose rats. This study demonstrates that high fructose-induced myocardial TG and glycogen accumulation is attributable to increased PDK-4. Besides, EEL could be a useful pharmacological utility for protection against cardiac dysmetabolism by inhibiting PDK-4.
C1 [Olaniyi, Kehinde Samuel; Olatunji, Lawrence Aderemi] Univ Ilorin, Coll Hlth Sci, HOPE Cardiometab Res Team, PMB 1515, Ilorin, Nigeria.
   [Olaniyi, Kehinde Samuel; Olatunji, Lawrence Aderemi] Univ Ilorin, Coll Hlth Sci, Dept Physiol, PMB 1515, Ilorin, Nigeria.
C3 University of Ilorin; University of Ilorin
RP Olatunji, LA (corresponding author), Univ Ilorin, Coll Hlth Sci, HOPE Cardiometab Res Team, PMB 1515, Ilorin, Nigeria.; Olatunji, LA (corresponding author), Univ Ilorin, Coll Hlth Sci, Dept Physiol, PMB 1515, Ilorin, Nigeria.
EM tunjilaw@unilorin.edu.ng
RI Olaniyi, Kehinde/GPK-5850-2022
OI Olatunji, Lawrence Aderemi/0000-0002-1036-0662; Olaniyi,
   Kehinde/0000-0002-8229-9688
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NR 76
TC 13
Z9 14
U1 0
U2 6
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0028-1298
EI 1432-1912
J9 N-S ARCH PHARMACOL
JI Naunyn-Schmiedebergs Arch. Pharmacol.
PD JAN
PY 2019
VL 392
IS 1
BP 89
EP 101
DI 10.1007/s00210-018-1568-3
PG 13
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA HF9GL
UT WOS:000454550400009
PM 30276420
DA 2025-06-11
ER

PT J
AU Lee, H
   Choi, JM
   Cho, JY
   Kim, TE
   Lee, HJ
   Jung, BH
AF Lee, Hyunbeom
   Choi, Jong Min
   Cho, Joo-Youn
   Kim, Tae-Eun
   Lee, Hwa Jeong
   Jung, Byung Hwa
TI Regulation of endogenic metabolites by rosuvastatin in hyperlipidemia
   patients: An integration of metabolomics and lipidomics
SO CHEMISTRY AND PHYSICS OF LIPIDS
LA English
DT Article
DE Rosuvastatin; Metabolomics; Lipidomics; Hyperlipidemia; Statin-induced
   myopathy
ID MITOCHONDRIAL DYSFUNCTION; PHOSPHOLIPASE A(2); MASS-SPECTROMETRY;
   OXIDATIVE STRESS; IDENTIFICATION; ATORVASTATIN; ASSOCIATION; BIOMARKERS;
   DRUGS
AB Rosuvastatin is a statin used to treat metabolic syndrome conditions, such as hyperlipidemia. It is relatively safe; however, fatal rhabdomyolysis or skeletal myopathy can sometimes occur. Therefore, to investigate the overall effects of rosuvastatin, including lipid lowering and adverse effects, metabolic profiling was performed using metabolomics and lipidomics after rosuvastatin administration. Specifically, the metabolic profiles between healthy subjects and patients with hyperlipidemia were compared and the metabolic changes related to the mechanism of the drug effect were proposed. Healthy volunteers (n = 32) and hyperlipidemic patients (n = 14) were orally administered rosuvastatin (20 mg) once a day for 3-8 weeks, and plasma and urine were collected. Metabolomics and lipidomics were performed using UHPLC-LTQ/Orbitrap/MS/MS for non-targeted analysis and UHPLC-TQ-MS/MS for targeted analysis. Using non-targeted analysis, we successfully profiled and identified 73 and 87 metabolites in healthy subjects and hyperlipidemia subjects, respectively. Through targeted analysis, we have also quantified 188 metabolites, including amino acids, biogenic amines, glycerophospholipids, and sphingolipids. The levels of L-carnitine, diacylglycerol, and acylcarnitines significantly decreased after rosuvastatin administration regardless of the group. The overall levels of fatty acids (FA) and lysophosphatidylcholines (LysoPC) increased, while phosphatidylcholines (PC) decreased only in the patient group. beta-Oxidation decreased overall, while the production of polyunsaturated FA increased only in the hyperlipidemic patients. Using metabolic profiling, we have evaluated the alterations in the biochemical pathways, which may aid in a more detailed understanding of the effect of rosuvastatin. Patient-specific metabolomic and lipidomic profiles may serve as valuable markers for the understanding of the adverse effects associated with statin treatment.
C1 [Lee, Hyunbeom; Choi, Jong Min; Jung, Byung Hwa] Korea Inst Sci & Technol, Mol Recognit Res Ctr, 5 Hwarang Ro 14 Gil, Seoul 02792, South Korea.
   [Cho, Joo-Youn; Kim, Tae-Eun] Seoul Natl Univ, Dept Clin Pharmacol & Therapeut, Coll Med & Hosp, Seoul, South Korea.
   [Choi, Jong Min; Lee, Hwa Jeong] Ewha Womans Univ, Coll Pharm, Seoul, South Korea.
   [Kim, Tae-Eun] Konkuk Univ, Dept Clin Pharmacol, Med Ctr, Seoul, South Korea.
   [Jung, Byung Hwa] Korea Univ Sci & Technol, KIST Sch, Div Biomed Sci & Technol, Seoul 02792, South Korea.
C3 Korea Institute of Science & Technology (KIST); Seoul National
   University (SNU); Ewha Womans University; Konkuk University; Konkuk
   University Medical Center; Korea Institute of Science & Technology
   (KIST)
RP Jung, BH (corresponding author), Korea Inst Sci & Technol, Mol Recognit Res Ctr, 5 Hwarang Ro 14 Gil, Seoul 02792, South Korea.
EM jbhluck@kist.re.kr
RI Cho, Joo-Youn/J-5672-2012
OI Lee, Hyunbeom/0000-0001-6954-7520; Cho, Joo-Youn/0000-0001-9270-8273
FU Creative Fusion Research Program through the Creative Allied Project -
   Korea Research Council of Fundamental Science and Technology
   [CAP-12-1-KIST]; Korea Food & Drug Administration [11182KFDA606];
   Bio-Synergy Research Project of the Ministry of Science, ICT and Future
   Planning through the National Research Foundation [NRF-2013M3A9C4078145]
FX This study was supported by the Creative Fusion Research Program through
   the Creative Allied Project funded by the Korea Research Council of
   Fundamental Science and Technology (CAP-12-1-KIST), by a grant from the
   Korea Food & Drug Administration (11182KFDA606), and by the Bio-Synergy
   Research Project (NRF-2013M3A9C4078145) of the Ministry of Science, ICT
   and Future Planning through the National Research Foundation.
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NR 49
TC 29
Z9 30
U1 0
U2 29
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0009-3084
EI 1873-2941
J9 CHEM PHYS LIPIDS
JI Chem. Phys. Lipids
PD AUG
PY 2018
VL 214
BP 69
EP 83
DI 10.1016/j.chemphyslip.2018.05.005
PG 15
WC Biochemistry & Molecular Biology; Biophysics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics
GA GN8HE
UT WOS:000439399700008
PM 29852124
DA 2025-06-11
ER

PT J
AU Yang, YM
   Zhang, Y
   Li, YH
   Ding, LL
   Sheng, LL
   Xie, ZJ
   Wen, CP
AF Yang, Yimin
   Zhang, Ying
   Li, Yanhua
   Ding, Lili
   Sheng, Lulu
   Xie, Zhijun
   Wen, Chengping
TI U-Shaped Relationship Between Functional Outcome and Serum Uric Acid in
   Ischemic Stroke
SO CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
LA English
DT Article
DE Cerebrovascular Stroke; Serum; Uric acid; Biomarker; Association
ID SHORT-TERM OUTCOMES; C-REACTIVE PROTEIN; OXIDATIVE STRESS;
   CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; LIQUID-CHROMATOGRAPHY;
   ANTIOXIDANT CAPACITY; CEREBRAL INFARCTION; CHINESE PATIENTS; RISK-FACTOR
AB Background/Aims: We sought to assess a consecutive number of patients with first-ever acute ischemic stroke (AIS), the clinical relevance in regard to functional outcome of the serum uric acid (SUA) measured at admission. Methods: In 2 prospective centers for observational study, serum concentrations of SUA were measured on admission in the serum of 710 consecutive patients with AIS. SUA concentrations were determined by high-performance liquid chromatography. SUA, NIH stroke scale (NIHSS), and conventional risk factors were evaluated to determine their value to predict functional outcome within 3 months. Results: During the follow-up, an unfavorable functional outcome (defined as a mRS score > 2) was found in 219 (30.8%) patients. The unfavorable functional outcome distribution across the SUA quartiles ranged between 12.4% (third quartile) and 50.6% (first quartile). After adjusting for all other significant outcome predictors, SUA concentration remained an independent unfavorable outcome predictor with an adjusted OR of 0.996 (95% CI, 0.993-0.998; P< 0.001). Conclusions: The data show that the U-shaped nature of the exposure-risk relationship was more prominent when the data were assessed in deciles (based on the SUA values). This model predicted the lowest relative risk of unfavorable outcome in the 67th percentile (corresponding to 309 mu mol/L). SUA was significantly associated with the risk of poor functional outcomes in Chinese patients with stroke. (C) 2018 The Author(s) Published by S. Karger AG, Basel
C1 [Yang, Yimin; Li, Yanhua; Ding, Lili; Sheng, Lulu] Jilin Univ, Hosp 1, Dept Intens Care Unit, 71 Xinmin St, Changchun 130000, Jilin, Peoples R China.
   [Zhang, Ying] Jilin Univ, Hosp 1, Dept Neurol, Changchun, Jilin, Peoples R China.
   [Zhang, Ying] Jilin Univ, Hosp 1, Neurosci Ctr, Changchun, Jilin, Peoples R China.
   [Xie, Zhijun; Wen, Chengping] Capital Med Univ, Beijing Rehabil Hosp, Dept Neurol, Beijing, Peoples R China.
C3 Jilin University; Jilin University; Jilin University; Capital Medical
   University
RP Sheng, LL (corresponding author), Jilin Univ, Hosp 1, Dept Intens Care Unit, 71 Xinmin St, Changchun 130000, Jilin, Peoples R China.
EM crookerince@163.com
RI Zhijun, Xie/JBJ-2835-2023
OI chengping, Wen/0000-0001-9254-6235
FU National Science Foundation of China [31600820]; Health and Family
   Planning Commission of Jilin Province [2016Q036]
FX This study was supported by the Supported by the grants from the
   National Science Foundation of China (No. 31600820) and The Health and
   Family Planning Commission of Jilin Province (No. 2016Q036). We express
   our gratitude to all the patients who participated in this study, and
   thereby made this work possible. All authors have contributed
   significantly, and that all authors are in agreement with the content of
   the manuscript.
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NR 52
TC 21
Z9 24
U1 0
U2 4
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1015-8987
EI 1421-9778
J9 CELL PHYSIOL BIOCHEM
JI Cell. Physiol. Biochem.
PY 2018
VL 47
IS 6
BP 2369
EP 2379
DI 10.1159/000491609
PG 11
WC Cell Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Physiology
GA GO6KR
UT WOS:000440152000015
PM 29991047
OA gold
DA 2025-06-11
ER

PT J
AU Komishon, AM
   Shishtar, E
   Ha, V
   Sievenpiper, JL
   de Souza, RJ
   Jovanovski, E
   Ho, HVT
   Duvnjak, LS
   Vuksan, V
AF Komishon, A. M.
   Shishtar, E.
   Ha, V.
   Sievenpiper, J. L.
   de Souza, R. J.
   Jovanovski, E.
   Ho, H. V. T.
   Duvnjak, L. S.
   Vuksan, V.
TI The effect of ginseng (genus Panax) on blood pressure: a
   systematic review and meta-analysis of randomized controlled clinical
   trials
SO JOURNAL OF HUMAN HYPERTENSION
LA English
DT Review
ID KOREAN RED GINSENG; ARTERIAL STIFFNESS; AMERICAN GINSENG; DOUBLE-BLIND;
   OXIDATIVE STRESS; GINSENOSIDES; RELAXATION; EFFICACY
AB Pre-clinical evidence indicates the potential for ginseng to reduce cardiovascular disease risk and acutely aid in blood pressure (BP) control. Clinical evidence evaluating repeated ginseng exposure, however, is controversial, triggering consumer and clinician concern. A systematic review and meta-analysis were conducted to assess whether ginseng has an effect on BP. MEDLINE, EMBASE, Cochrane and CINAHL were searched for relevant randomized controlled trials >= 4 weeks that compared the effect of ginseng on systolic (SBP), diastolic (DBP) and/or mean arterial (MAP) BPs to control. Two independent reviewers extracted data and assessed methodological quality and risk of bias. Data were pooled using random-effects models and expressed as mean differences (MD) with 95% confidence intervals (CIs). Heterogeneity was assessed and quantified. Seventeen studies satisfied eligibility criteria (n = 1381). No significant effect of ginseng on SBP, DBP and MAP was found. Stratified analysis, although not significant, appears to favour systolic BP improvement in diabetes, metabolic syndrome and obesity (MD = -2.76 mm Hg (95% CI = -6.40, 0.87); P = 0.14). A priori subgroup analyses revealed significant association between body mass index and treatment differences (beta = -0.95 mm Hg (95% CI = -1.56, -0.34); P = 0.007). Ginseng appears to have neutral vascular affects; therefore, should not be discouraged for concern of increased BP. More high-quality, randomized, controlled trials assessing BP as a primary end point, and use of standardized ginseng root or extracts are warranted to limit evidence of heterogeneity in ginseng research and to better understand its cardiovascular health potential.
C1 [Komishon, A. M.; Shishtar, E.; Ha, V.; Sievenpiper, J. L.; de Souza, R. J.; Jovanovski, E.; Ho, H. V. T.; Vuksan, V.] St Michaels Hosp, Clin Nutr & Risk Factor Modificat Ctr, 193 Yonge St, Toronto, ON M5B 1M8, Canada.
   [Komishon, A. M.; Shishtar, E.; Ha, V.; Jovanovski, E.; Ho, H. V. T.; Vuksan, V.] Univ Toronto, Dept Nutrit Sci, Fac Med, Toronto, ON, Canada.
   [Sievenpiper, J. L.] McMaster Univ, Dept Pathol, Fac Hlth Sci, Hamilton, ON, Canada.
   [Sievenpiper, J. L.] McMaster Univ, Dept Mol Med, Fac Hlth Sci, Hamilton, ON, Canada.
   [de Souza, R. J.] McMaster Univ, Dept Clin Epidemiol & Biostat, Hamilton, ON, Canada.
   [Jovanovski, E.; Vuksan, V.] St Michaels Hosp, Li Ka Shing Knowledge Inst, Toronto, ON, Canada.
   [Duvnjak, L. S.] Univ Zagreb, Sch Med, Univ Clin Diabet Endocrinol & Metab Dis, Zagreb, Croatia.
   [Vuksan, V.] Univ Toronto, Dept Med, Fac Med, Toronto, ON, Canada.
C3 University of Toronto; Saint Michaels Hospital Toronto; University of
   Toronto; McMaster University; McMaster University; McMaster University;
   University of Toronto; Saint Michaels Hospital Toronto; Li Ka Shing
   Knowledge Institute; University of Zagreb; University of Toronto
RP Vuksan, V (corresponding author), St Michaels Hosp, Clin Nutr & Risk Factor Modificat Ctr, 193 Yonge St, Toronto, ON M5B 1M8, Canada.
EM v.vuksan@utoronto.ca
RI Ha, Vanessa/KPB-5212-2024; de Souza, Russell/ABB-7735-2021; Sievenpiper,
   John/JVN-7555-2024; duvnjak, lea/S-8581-2018
OI duvnjak, lea/0000-0001-8173-5348; de Souza, Russell/0000-0001-8945-513X
FU Canadian Diabetes Association (CDA), Canada; National Institute of
   Horticultural and Herbal Science, RDA, Korea; Canadian Institutes of
   Health Research (CIHR); Calorie Control Council; Coca-Cola Company;
   Pulse Canada; International Tree Nut Council Nutrition Research and
   Education Foundation; American Heart Association; American College of
   Physicians; American Society for Nutrition; National Institute of
   Diabetes and Digestive and Kidney Diseases of the National Institutes of
   Health; CDA; Canadian Nutrition Society; Diabetes and Nutrition Study
   Group of the European Association for the Study of Diabetes;
   International Life Sciences Institute North America; International Life
   Sciences Institute, Brazil; Abbott Laboratories; Dr Pepper Snapple
   Group; CIHR; Canadian Foundation for Dietetic Research; Embassy of the
   State of Kuwait, Kuwait University; Ontario Graduate Scholarship (OGS)
FX VV is holder of an American (No. 7,326,404 B2) and Canadian (No.
   2,410,556) patent for use of viscous fibre blend in diabetes, metabolic
   syndrome and cholesterol lowering; currently holds grant support for
   ginseng research from the Canadian Diabetes Association (CDA), Canada
   and the National Institute of Horticultural and Herbal Science, RDA,
   Korea. JLS has received research support from the Canadian Institutes of
   Health Research (CIHR), the Calorie Control Council, Coca-Cola Company
   (investigator initiated, unrestricted grant), Pulse Canada, and the
   International Tree Nut Council Nutrition Research and Education
   Foundation. He has received travel funding, speaker fees and/or
   honoraria from the American Heart Association, the American College of
   Physicians, the American Society for Nutrition, the National Institute
   of Diabetes and Digestive and Kidney Diseases of the National Institutes
   of Health, the CDA, the Canadian Nutrition Society, the Calorie Control
   Council, the Diabetes and Nutrition Study Group of the European
   Association for the Study of Diabetes, the International Life Sciences
   Institute North America, the International Life Sciences Institute,
   Brazil, the Abbott Laboratories, Pulse Canada, Dr Pepper Snapple Group
   and Coca-Cola Company. He is on the Clinical Practice Guidelines Expert
   Committee for Nutrition Therapy of both the CDA and the European
   Association for the study of diabetes, as well as being on the American
   Society for Nutrition writing panel for a scientific statement on the
   metabolic and nutritional effects of fructose, sucrose and high-fructose
   corn syrup. He is an unpaid scientific advisor for the International
   Life Science Institute North America, Food, Nutrition and Safety
   Program. His wife is employed by Unilever Canada. RJdS is funded by a
   CIHR Postdoctoral Fellowship Award and has received research support
   from the CIHR, the Calorie Control Council, the Canadian Foundation for
   Dietetic Research and Coca-Cola Company (investigator initiated,
   unrestricted grant). He has served as an external resource person to the
   WHO's Nutrition Guidelines Advisory Group and received travel support
   from WHO to attend group meetings. He is the lead author of two
   systematic reviews and meta-analyses commissioned by WHO of the relation
   of saturated fatty acids and trans fatty acids with health outcomes. ES
   received funding from the Embassy of the State of Kuwait, Kuwait
   University. VH has received research support from the Ontario Graduate
   Scholarship (OGS) and the CIHR. AK, EJ and SBM have declared no conflict
   of interest.
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NR 36
TC 21
Z9 22
U1 1
U2 29
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0950-9240
EI 1476-5527
J9 J HUM HYPERTENS
JI J. Hum. Hypertens.
PD OCT
PY 2016
VL 30
IS 10
SI SI
BP 619
EP 626
DI 10.1038/jhh.2016.18
PG 8
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA DZ3ZY
UT WOS:000385797000008
PM 27074879
DA 2025-06-11
ER

PT J
AU Milbank, E
   Martinez, MC
   Andriantsitohaina, R
AF Milbank, Edward
   Martinez, M. Carmen
   Andriantsitohaina, Ramaroson
TI Extracellular vesicles: Pharmacological modulators of the peripheral and
   central signals governing obesity
SO PHARMACOLOGY & THERAPEUTICS
LA English
DT Review
DE Obesity; Peripheral/central regulation; Extracellular vesicles;
   Pharmacotherapy; Targets; Tools
ID ACTIVATED PROTEIN-KINASE; CELL-DERIVED EXOSOMES; ENDOPLASMIC-RETICULUM
   STRESS; CONTROLLED-RELEASE PHENTERMINE/TOPIRAMATE; ENDOTHELIAL
   PROGENITOR CELLS; FOOD-INTAKE; WEIGHT-LOSS; HYPERTENSIVE PATIENTS;
   INSULIN-RESISTANCE; TISSUE-FACTOR
AB Obesity and its metabolic resultant dysfunctions such as insulin resistance, hyperglycemia, dyslipidemia and hypertension, grouped as the "metabolic syndrome", are chronic inflammatory disorders that represent one of the most severe epidemic health problems. The imbalance between energy intake and expenditure, leading to an excess of body fat and an increase of cardiovascular and diabetes risks, is regulated by the interaction between central nervous system (CNS) and peripheral signals in order to regulate behavior and finally, the metabolism of peripheral organs. At present, pharmacological treatment of obesity comprises actions in both CNS and peripheral organs. In the last decades, the extracellular vesicles have emerged as participants in many pathophysiological regulation processes. Whether used as biomarkers, targets or even tools, extracellular vesicles provided some promising effects in the treatment of a large variety of diseases. Extracellular vesicles are released by cells from the plasma membrane (microvesicles) or from multivesicular bodies (exosomes) and contain lipids, proteins and nucleic acids, such as DNA, protein coding, and non-coding RNAs. Owing to their composition, extracellular vesicles can (i) activate receptors at the target cell and then, the subsequent intracellular pathway associated to the specific receptor; (ii) transfer molecules to the target cells and thereby change their phenotype and (iii) be used as shuttle of drugs and, thus, to carry specific molecules towards specific cells. Herein, we review the impact of extracellular vesicles in modulating the central and peripheral signals governing obesity. (C) 2015 Elsevier Inc. All rights reserved.
C1 [Milbank, Edward; Martinez, M. Carmen; Andriantsitohaina, Ramaroson] Univ Angers, INSERM, UMR1063, Stress Oxydant & Pathol Metabol, Angers, France.
C3 Universite d'Angers; Institut National de la Sante et de la Recherche
   Medicale (Inserm)
RP Andriantsitohaina, R (corresponding author), Univ Angers, INSERM, UMR1063, Stress Oxydant & Pathol Metabol, Angers, France.
EM ramaroson.andriantsitohaina@univ-angers.fr
RI ANDRIANTSITOHAINA, Ramaroson/H-5286-2018; Martinez, Maria
   Carmen/LSJ-1622-2024; MILBANK, Edward/ABF-5946-2021
OI andriantsitohaina, ramaroson/0000-0002-4770-3585; Martinez, M
   Carmen/0000-0003-3897-7397; MILBANK, Edward/0000-0003-3897-5586
FU Nanofar Erasmus Mundus Program
FX EM is recipient of a doctoral fellowship from Nanofar Erasmus Mundus
   Program.
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SN 0163-7258
EI 1879-016X
J9 PHARMACOL THERAPEUT
JI Pharmacol. Ther.
PD JAN
PY 2016
VL 157
BP 65
EP 83
DI 10.1016/j.pharmthera.2015.11.002
PG 19
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA DC1DN
UT WOS:000368957100005
PM 26617220
DA 2025-06-11
ER

PT J
AU Salomone, F
   Godos, J
   Zelber-Sagi, S
AF Salomone, Federico
   Godos, Justyna
   Zelber-Sagi, Shira
TI Natural antioxidants for non-alcoholic fatty liver disease: molecular
   targets and clinical perspectives
SO LIVER INTERNATIONAL
LA English
DT Review
DE fibrosis; NASH; nutraceuticals; oxidative stress; polyphenols
ID HEPATIC STELLATE CELLS; FACTOR-KAPPA-B; IMPROVES INSULIN-RESISTANCE;
   E-PHOSPHOLIPID COMPLEX; GREEN TEA POLYPHENOL; MESSENGER-RNA LEVELS;
   DIET-INDUCED OBESITY; METABOLIC SYNDROME; EPIGALLOCATECHIN GALLATE;
   COFFEE CONSUMPTION
AB Non-alcoholic steatohepatitis (NASH), the progressive form of non-alcoholic fatty liver disease (NAFLD), is emerging as a main health problem in industrialized countries. Lifestyle modifications are effective in the treatment of NAFLD; however, the long-term compliance is low. Therefore, several pharmacological treatments have been proposed but none has shown significant efficacy or long-term safety. Natural polyphenols are a heterogeneous class of polyphenolic compounds contained in vegetables, which are being proposed for the treatment of different metabolic disorders. Although the beneficial effect of these compounds has traditionally related to their antioxidant properties, they also exert several beneficial effects on hepatic and extra-hepatic glucose and lipid homeostasis. Furthermore, natural polyphenols exert antifibrogenic and antitumoural effects in animal models, which appear relevant from a clinical point of view because of the association of NASH with cirrhosis and hepatocellular carcinoma. Several polyphenols, such anthocyanins, curcumin and resveratrol and those present in coffee, tea, soy are available in the diet and their consumption can be proposed as part of a healthy diet for the treatment of NAFLD. Other phenolic compounds, such as silymarin, are commonly consumed worldwide as nutraceuticals or food supplements. Natural antioxidants are reported to have beneficial effects in preclinical models of NAFLD and in pilot clinical trials, and thus need clinical evaluation. In this review, we summarize the existing evidence regarding the potential role of natural antioxidants in the treatment of NAFLD and examine possible future clinical applications.
C1 [Salomone, Federico] Azienda Sanit Prov Catania, Osped Acireale, Div Gastroenterol, Catania, Italy.
   [Godos, Justyna] Univ Catania, Dept Biomed & Biotechnol Sci, Catania, Italy.
   [Zelber-Sagi, Shira] Tel Aviv Med Ctr & Sch Med, Dept Gastroenterol, Liver Unit, Tel Aviv, Israel.
   [Zelber-Sagi, Shira] Univ Haifa, Sch Publ Hlth, IL-31999 Haifa, Israel.
C3 University of Catania; Tel Aviv University; Sackler Faculty of Medicine;
   University of Haifa
RP Salomone, F (corresponding author), Osped Acireale, UOC Gastroenterol, Via Caronia, I-95024 Acireale, Italy.
EM federicosalomone@rocketmail.com
RI Godos, Justyna/AAC-1302-2019; Salomone, Federico/R-6598-2016
OI Salomone, Federico/0000-0001-5264-2935; Godos,
   Justyna/0000-0002-5809-5706
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NR 114
TC 209
Z9 220
U1 6
U2 131
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1478-3223
EI 1478-3231
J9 LIVER INT
JI Liver Int.
PD JAN
PY 2016
VL 36
IS 1
BP 5
EP 20
DI 10.1111/liv.12975
PG 16
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA DA3UC
UT WOS:000367723500001
PM 26436447
OA Bronze
DA 2025-06-11
ER

PT J
AU Spracklen, CN
   Smith, CJ
   Saftlas, AF
   Robinson, JG
   Ryckman, KK
AF Spracklen, Cassandra N.
   Smith, Caitlin J.
   Saftlas, Audrey F.
   Robinson, Jennifer G.
   Ryckman, Kelli K.
TI Maternal Hyperlipidemia and the Risk of Preeclampsia: A Meta-Analysis
SO AMERICAN JOURNAL OF EPIDEMIOLOGY
LA English
DT Article
DE body mass index; cholesterol; hyperlipidemia; hypertriglyceridemia;
   meta-analysis; preeclampsia; systematic review; triglycerides
ID LOW-DENSITY-LIPOPROTEIN; PLASMA-LIPID CONCENTRATIONS; APOLIPOPROTEIN-E;
   CARDIOVASCULAR RISK; INSULIN-RESISTANCE; OXIDATIVE STRESS;
   EARLY-PREGNANCY; SERUM-LEVELS; PARAOXONASE ACTIVITY; METABOLIC SYNDROME
AB Published reports examining lipid levels during pregnancy and preeclampsia have been inconsistent. The objective of this meta-analysis was to test the association between preeclampsia and maternal total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), non-HDL-C, and triglyceride levels measured during pregnancy. We conducted a systematic search for studies published between the index date until July 2013 reporting maternal lipid levels in women with preeclampsia and normotensive pregnant women. Seventy-four studies met all eligibility criteria and were included in the meta-analysis. Weighted mean differences in lipid levels were calculated using a random-effects model. Statistical heterogeneity was investigated using the I-2 statistic. Meta-regression was used to identify sources of heterogeneity. Preeclampsia was associated with elevated total cholesterol, non-HDL-C, and triglyceride levels, regardless of gestational age at the time of blood sampling, and with lower levels of HDL-C in the third trimester. A marginal association was found with LDL-C levels. Statistical heterogeneity was detected in all analyses. Meta-regression analyses suggested that differences in body mass index (weight (kg)/height (m)(2)) across studies may be partially responsible for the heterogeneity in the triglyceride and LDL-C analyses. This systematic review and meta-analysis demonstrates that women who develop preeclampsia have elevated levels of total cholesterol, non-HDL-C, and triglycerides during all trimesters of pregnancy, as well as lower levels of HDL-C during the third trimester.
C1 [Spracklen, Cassandra N.; Smith, Caitlin J.; Saftlas, Audrey F.; Robinson, Jennifer G.; Ryckman, Kelli K.] Univ Iowa, Coll Publ Hlth, Dept Epidemiol, Iowa City, IA 52242 USA.
C3 University of Iowa
RP Ryckman, KK (corresponding author), Univ Iowa, Coll Publ Hlth, Dept Epidemiol, 145 Riverside Dr,S414 CPHB, Iowa City, IA 52242 USA.
EM kelli-ryckman@uiowa.edu
RI , Jennifer/AAD-8336-2019
OI Ryckman, Kelli/0000-0002-9496-4147
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NR 101
TC 185
Z9 198
U1 3
U2 15
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0002-9262
EI 1476-6256
J9 AM J EPIDEMIOL
JI Am. J. Epidemiol.
PD AUG 15
PY 2014
VL 180
IS 4
BP 346
EP 358
DI 10.1093/aje/kwu145
PG 13
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA AQ7XD
UT WOS:000343032100002
PM 24989239
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Chiang, CC
   Lin, CL
   Peng, CL
   Sung, FC
   Tsai, YY
AF Chiang, Chun Chi
   Lin, Cheng-Li
   Peng, Chiao-Ling
   Sung, Fung-Chang
   Tsai, Yi-Yu
TI Increased risk of cancer in patients with early-onset cataracts: A
   nationwide population-based study
SO CANCER SCIENCE
LA English
DT Article
DE Cancer; cohort study; early-onset cataracts; incidence; retrospective
ID GLUTATHIONE-S-TRANSFERASE; OXIDATIVE STRESS; HEPATOCELLULAR-CARCINOMA;
   ULTRAVIOLET-RADIATION; METABOLIC SYNDROME; BREAST-CANCER; POLYMORPHISMS;
   FIBROBLASTS; EXPOSURE; DISEASE
AB Early-onset cataracts are associated with insufficient antioxidative activity, and, therefore, a potential risk of cancer. This study investigated the risk of cancer after being diagnosed with early-onset cataracts. Retrospective claims data from the Taiwan National Health Insurance Research Database were analyzed. Study subjects were comprised of patients with early-onset cataracts, aged 20-55years (International Classification of Diseases, 9th Revision, Clinical Modification [ICD-9-CM] code 366.00, 366.01, 366.02, 366.03, 366.04, 366.09, 366.17 and 366.18) and newly diagnosed between 1997 and 2010 (n=1281), and a comparison cohort without the disease (n=5124). Both cohorts were followed up until 2010 to estimate the incidences of cancer. We used the Poisson regression model to compare incidence rate ratios and the 95% confidence interval (CI). Cox proportional hazards regression was used to assess the hazard ratio (HR) of cancer associated with early-onset cataracts. The overall incidence rate of all cancers was 2.19-fold higher in the early-onset cataract cohort than in the comparison cohort (8.06 vs 3.68 per 1000person-years) with an adjusted HR of 2.13 (95% CI=1.48, 3.07). The site-specific analysis also showed a strong relationship, with adjusted HR of 3.24 ((95% CI=1.30, 8.10) for head and neck cancer, 3.29 (95% CI 1.16, 9.31) for hepatoma and 3.19 (95% CI 1.34, 7.58) for breast cancer. The present study suggests that patients with early-onset cataracts are at an increased risk of being diagnosed with cancer in subsequent years.
C1 [Chiang, Chun Chi; Tsai, Yi-Yu] Div Ophthalmol, Taichung, Taiwan.
   [Lin, Cheng-Li; Peng, Chiao-Ling; Sung, Fung-Chang] China Med Univ Hosp, Management Off Hlth Data, Taichung 404, Taiwan.
   [Chiang, Chun Chi; Tsai, Yi-Yu] China Med Univ, Sch Med, Coll Med, Taichung, Taiwan.
   [Lin, Cheng-Li; Peng, Chiao-Ling; Sung, Fung-Chang] China Med Univ, Dept Publ Hlth, Coll Publ Hlth, Taichung 404, Taiwan.
C3 China Medical University Taiwan; China Medical University Hospital -
   Taiwan; China Medical University Taiwan; China Medical University Taiwan
RP Tsai, YY (corresponding author), China Med Univ Hosp, Div Ophthalmol, 2 Yuh Der Rd, Taichung 404, Taiwan.
EM fcsung@mail.cmu.edu.tw; elsa10019@yahoo.com.tw
RI Chang, Chun-Hung/AAT-1641-2021; Liao, Yu-Chi/AAT-1357-2021
OI Lin, Cheng-Li/0000-0001-9926-3668
FU National Sciences Council, Executive Yuan [SC99-2621-M-039-001]; China
   Medical University Hospital [1MS1, DMR-103-065, DMR-103-067]; Taiwan
   Department of Health Clinical Trial and Research Center for Excellence
   [DOH101-TD-B-111-004]; Cancer Research Center of Excellence
   [DOH101-TD-C-111-005]
FX Support was provided in part by the National Sciences Council, Executive
   Yuan (grant numbers SC99-2621-M-039-001), China Medical University
   Hospital (grant number 1MS1, DMR-103-065 and DMR-103-067), Taiwan
   Department of Health Clinical Trial and Research Center for Excellence
   (grant number DOH101-TD-B-111-004) and Cancer Research Center of
   Excellence (DOH101-TD-C-111-005).
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NR 32
TC 8
Z9 9
U1 0
U2 5
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1349-7006
J9 CANCER SCI
JI Cancer Sci.
PD APR
PY 2014
VL 105
IS 4
BP 431
EP 436
DI 10.1111/cas.12360
PG 6
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA AE8GW
UT WOS:000334238800009
PM 24450445
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Kamari, Y
   Peleg, E
   Leibowitz, A
   Grossman, E
AF Kamari, Yehuda
   Peleg, Edna
   Leibowitz, Avshalom
   Grossman, Ehud
TI Blunted Blood Pressure Response and Elevated Plasma Adiponectin Levels
   in Female Sprague Dawley Rats
SO AMERICAN JOURNAL OF HYPERTENSION
LA English
DT Article
DE adiponectin; blood pressure; gender difference; hypertension;
   testosterone
ID ADIPOSE-SPECIFIC PROTEIN; GENDER-DIFFERENCES; METABOLIC SYNDROME;
   INSULIN-RESISTANCE; HYPERTENSIVE-RATS; DEFICIENT MICE; HEART-DISEASE;
   SEX-HORMONES; RISK-FACTORS; TESTOSTERONE
AB BACKGROUND
   Premenopausal women have lower blood pressure (BP) levels than men of similar age. Adiponectin has been shown to play a role in the pathogenesis of hypertension. The aim of the present study was to compare the effect of various stress stimuli on BP and plasma adiponectin levels in male and female Sprague Dawley (SD) rats.
   METHODS
   In three experimental models of hypertension, fructose-enriched diet, high salt diet, or L-NAME, were administered for up to 4 weeks. BP, metabolic parameters, and plasma adiponectin were measured at baseline and during the studies. The fructose diet protocol was repeated in female rats for 2 weeks with the addition of testosterone injections or vehicle.
   RESULTS
   Females, in contrast to males, did not develop fructose-induced hypertension. Total plasma triglycerides (TGs) were half in females at baseline (P < 0.001) and a third at 4 weeks (P < 0.05). Plasma insulin levels were 23% lower in females than in males at baseline (P < 0.05) and 42% lower after 4 weeks of fructose-enriched diet (P = 0.001). Plasma adiponectin levels were 65% higher in females than in males at baseline (P = 0.001) and 45% higher after 4 weeks of fructose-enriched diet (P < 0.05). Furthermore, female rats showed blunted BP response and elevated plasma adiponectin in the salt-induced and L-NAME-induced hypertension models. Testosterone injection to female rats reduced plasma adiponectin and reversed the blunted BP response.
   CONCLUSIONS
   Elevated plasma adiponectin levels, perhaps due to lack of suppression by testosterone, are associated with a blunting of BP response in female compared to male SD rats.
C1 [Kamari, Yehuda; Peleg, Edna; Leibowitz, Avshalom; Grossman, Ehud] Chaim Sheba Med Ctr, Hypertens Unit, IL-52621 Tel Hashomer, Israel.
   [Kamari, Yehuda] Chaim Sheba Med Ctr, Bert W Strassburger Lipid Ctr, IL-52621 Tel Hashomer, Israel.
   [Kamari, Yehuda; Leibowitz, Avshalom; Grossman, Ehud] Tel Aviv Univ, Sackler Fac Med, IL-69978 Tel Aviv, Israel.
C3 Chaim Sheba Medical Center; Chaim Sheba Medical Center; Tel Aviv
   University; Sackler Faculty of Medicine
RP Kamari, Y (corresponding author), Chaim Sheba Med Ctr, Hypertens Unit, IL-52621 Tel Hashomer, Israel.
EM yehuda.kamari@sheba.health.gov.il
OI Grossman, Ehud/0000-0001-8353-0661
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NR 42
TC 14
Z9 17
U1 0
U2 4
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 0895-7061
J9 AM J HYPERTENS
JI Am. J. Hypertens.
PD MAY
PY 2012
VL 25
IS 5
BP 612
EP 619
DI 10.1038/ajh.2011.260
PG 8
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 927ZX
UT WOS:000302950400015
PM 22258332
OA Bronze
DA 2025-06-11
ER

PT J
AU González-Rodríguez, A
   Más-Gutierrez, JA
   Mirasierra, M
   Fernandez-Pérez, A
   Lee, YJ
   Ko, HJ
   Kim, JK
   Romanos, E
   Carrascosa, JM
   Ros, M
   Vallejo, M
   Rondinone, CM
   Valverde, AM
AF Gonzalez-Rodriguez, Agueda
   Mas-Gutierrez, Jose A.
   Mirasierra, Mercedes
   Fernandez-Perez, Antonio
   Lee, Yong J.
   Ko, Hwi J.
   Kim, Jason K.
   Romanos, Eduardo
   Carrascosa, Jose M.
   Ros, Manuel
   Vallejo, Mario
   Rondinone, Cristina M.
   Valverde, Angela M.
TI Essential role of protein tyrosine phosphatase 1B in obesity-induced
   inflammation and peripheral insulin resistance during aging
SO AGING CELL
LA English
DT Article
DE insulin resistance; type 2 diabetes; obesity; inflammation; PTP1B
ID ADIPOSE-TISSUE; IN-VIVO; METABOLIC SYNDROME; UP-REGULATION; MICE;
   SENSITIVITY; RECEPTOR; LIVER; HEPATOCYTES; EXPRESSION
AB Protein tyrosine phosphatase 1B (PTP1B) is a negative regulator of insulin signaling and a therapeutic target for type 2 diabetes (T2DM). In this study, we have evaluated the role of PTP1B in the development of aging-associated obesity, inflammation, and peripheral insulin resistance by assessing metabolic parameters at 3 and 16 months in PTP1B-/- mice maintained on mixed genetic background (C57Bl/6J x 129Sv/J). Whereas fat mass and adipocyte size were increased in wild-type control mice at 16 months, these parameters did not change with aging in PTP1B-/- mice. Increased levels of pro-inflammatory cytokines, crown-like structures, and hypoxia-inducible factor (HIF)-1a were observed only in adipose tissue from 16-month-old wild-type mice. Similarly, islet hyperplasia and hyperinsulinemia were observed in wild-type mice with aging-associated obesity, but not in PTP1B-/- animals. Leanness in 16-month-old PTP1B-/- mice was associated with increased energy expenditure. Whole-body insulin sensitivity decreased in 16-month-old control mice; however, studies with the hyperinsulinemiceuglycemic clamp revealed that PTP1B deficiency prevented this obesity-related decreased peripheral insulin sensitivity. At a molecular level, PTP1B expression and enzymatic activity were up-regulated in liver and muscle of 16-month-old wild-type mice as were the activation of stress kinases and the expression of p53. Conversely, insulin receptor-mediated Akt/Foxo1 signaling was attenuated in these aged control mice. Collectively, these data implicate PTP1B in the development of inflammation and insulin resistance associated with obesity during aging and suggest that inhibition of this phosphatase by therapeutic strategies might protect against age-dependent T2DM.
C1 [Gonzalez-Rodriguez, Agueda; Mirasierra, Mercedes; Fernandez-Perez, Antonio; Vallejo, Mario; Valverde, Angela M.] Inst Biomed Alberto Sols CSIC UAM, Madrid 28029, Spain.
   [Gonzalez-Rodriguez, Agueda; Mirasierra, Mercedes; Fernandez-Perez, Antonio; Vallejo, Mario; Valverde, Angela M.] Ctr Invest Biomed Red Diabet & Enfermedades Metab, Madrid, Spain.
   [Mas-Gutierrez, Jose A.; Ros, Manuel] Univ Rey Juan Carlos, Fac Hlth Sci, Madrid 28922, Spain.
   [Lee, Yong J.; Ko, Hwi J.; Kim, Jason K.] Univ Massachusetts, Sch Med, Div Endocrinol Metab & Diabet, Program Mol Med, Worcester, MA 01605 USA.
   [Kim, Jason K.] Univ Massachusetts, Div Endocrinol, Sch Med, Div Endocrinol Metab & Diabet, Worcester, MA 01605 USA.
   [Romanos, Eduardo] IIS Aragon, Phenotyping Unit, Zaragoza, Spain.
   [Carrascosa, Jose M.] Ctr Mol Biol Severo Ochoa CSIC UAM, Madrid 28049, Spain.
   [Rondinone, Cristina M.] Abbott Labs, Global Pharmaceut Res Div, Dept 47R, Abbott Pk, IL 60064 USA.
C3 Consejo Superior de Investigaciones Cientificas (CSIC); CIBER - Centro
   de Investigacion Biomedica en Red; CIBERDEM; Universidad Rey Juan
   Carlos; University of Massachusetts System; University of Massachusetts
   Worcester; University of Massachusetts System; University of
   Massachusetts Worcester; Consejo Superior de Investigaciones Cientificas
   (CSIC); CSIC - Centro de Biologia Molecular Severo Ochoa (CBM); Abbott
   Laboratories
RP Valverde, AM (corresponding author), Inst Biomed Alberto Sols CSIC UAM, C Arturo Duperier 4, Madrid 28029, Spain.
EM avalverde@iib.uam.es
RI Carrascosa, Jose/ABE-3526-2021; Vallejo, Mario/ABG-4610-2020; Kim, Jung
   Kyu/C-3271-2012; Mirasierra, Mercedes/ABG-6999-2020; Gonzalez-Rodriguez,
   Agueda/D-7651-2012; Romanos, Eduardo/T-3794-2017
OI Kim, Jason/0000-0002-7185-042X; Gonzalez-Rodriguez,
   Agueda/0000-0001-6559-0847; Vallejo, Mario/0000-0002-6422-0323;
   Mirasierra, Mercedes/0000-0002-0023-8903; Gonzalez-Rodriguez,
   Agueda/0000-0003-2851-2318; Ros, Manuel/0000-0003-2982-513X; Martinez
   Valverde, Angela/0000-0003-1192-9045; Fernandez-Perez,
   Antonio/0000-0001-6866-5824; Romanos, Eduardo/0000-0002-9918-3374
FU Ministerio de Ciencia e Innovacion (Spain) [SAF2009-08114,
   BFU2008-04901-C03-02, BFU2008-04901-C03-03, BFU2008-01283]; Comunidad de
   Madrid [S2010/BMD-2423]; Centro de Investigacion Biomedica en Red de
   Diabetes y Enfermedades Metabolicas Asociadas (CIBERDEM) (Instituto
   Salud Carlos III); UMass Diabetes and Endocrinology Research Center
   [DK32520]; EFSD/Amylin Programme;  [NIH-R01 DK080756];  [ADA
   7-07-RA-80];  [NIH U24-DK093000]
FX This work was supported by grants from Ministerio de Ciencia e
   Innovacion (Spain) SAF2009-08114 and (to A. M. V.), BFU2008-04901-C03-02
   and 03 (to M. R and J.M.C., respectively), BFU2008-01283 (to M. V),
   Comunidad de Madrid S2010/BMD-2423 and Centro de Investigacion Biomedica
   en Red de Diabetes y Enfermedades Metabolicas Asociadas (CIBERDEM)
   (Instituto Salud Carlos III). CBMSO is recipient of institutional aid
   from Ramon Areces Foundation. We also acknowledge grants NIH-R01
   DK080756, ADA 7-07-RA-80, and NIH U24-DK093000 (to J.K.K.) and UMass
   Mouse Phenotyping Center supported by UMass Diabetes and Endocrinology
   Research Center Grant (DK32520) and EFSD/Amylin Programme 2011 grant (to
   A. M. V.). We would like to thank S. Kinicki and L. Li for assisting in
   the clamp study and D. Burks (CIPF, Spain) for critical reading of the
   manuscript and English editing. A.G.-R., A. F.-P and M. M. hold
   postdoctoral contracts from CIBERDEM. No potential conflicts of interest
   relevant to this article were reported.
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NR 44
TC 76
Z9 83
U1 0
U2 15
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1474-9718
J9 AGING CELL
JI Aging Cell
PD APR
PY 2012
VL 11
IS 2
BP 284
EP 296
DI 10.1111/j.1474-9726.2011.00786.x
PG 13
WC Cell Biology; Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Geriatrics & Gerontology
GA 908WF
UT WOS:000301523000014
PM 22221695
OA Green Submitted, hybrid, Green Published, Green Accepted
DA 2025-06-11
ER

PT J
AU Nishida, Y
   Iyadomi, M
   Higaki, Y
   Tanaka, H
   Hara, M
   Tanaka, K
AF Nishida, Yuichiro
   Iyadomi, Minako
   Higaki, Yasuki
   Tanaka, Hiroaki
   Hara, Megumi
   Tanaka, Keitaro
TI Influence of Physical Activity Intensity and Aerobic Fitness on the
   Anthropometric Index and Serum Uric Acid Concentration in People with
   Obesity
SO INTERNAL MEDICINE
LA English
DT Article
DE lactate threshold; metabolic equivalents; hyperuricemia
ID VISCERAL FAT ACCUMULATION; OXIDATIVE STRESS; GLUCOSE EFFECTIVENESS;
   ENERGY-EXPENDITURE; METABOLIC SYNDROME; ACTIVITY LEVEL; RISK-FACTORS;
   EXERCISE; INSULIN; URATE
AB Background and Objective Physical activity (PA) is considered an important approach to prevent and treat obesity and hyperuricemia. The purpose of the present study was to examine the influence of PA intensity and aerobic fitness on anthropometric indices and serum uric acid in obese individuals.
   Methods PA was examined using a single-axial accelerometer and aerobic fitness was assessed by electric cycle ergometry in obese middle-aged men (n=71, 47.2 +/- 4.4 years). PA was defined as light (<3 metabolic equivalents [METs]), moderate (3.0-6.0 METs) or vigorous (>6.0 METs) intensity from the corresponding METs multiplied by time spent at the corresponding intensity levels. Serum uric acid was measured by the uricase peroxidase method.
   Results The association between aerobic fitness index (lactate threshold) and serum uric acid did not reach statistical significance after adjustment for potential confounding factors (age, body mass index [BMI], and alcohol consumption) (beta=-0.110, p=0.138). Light intensity PA was inversely associated with BMI and waist circumference, even after adjustment for age and alcohol consumption (BMI: beta=-0.543, p=0.023; waist circumference: beta=-1.333, p=0.016). Moderate intensity PA, but not light or vigorous intensity PA, was inversely correlated with the uric acid level and this remained significant after adjustment for age, BMI, and alcohol consumption (beta=-0.222, p=0.036).
   Conclusion Our results suggest that light intensity PA may have an important role in weight control while moderate intensity PA may be associated with the lower uric acid concentrations in obese individuals.
C1 [Nishida, Yuichiro; Hara, Megumi; Tanaka, Keitaro] Saga Univ, Dept Prevent Med, Fac Med, Saga, Japan.
   [Higaki, Yasuki; Tanaka, Hiroaki] Fukuoka Univ, Fac Hlth & Sports Sci, Exercise Physiol Lab, Fukuoka, Japan.
C3 Saga University; Fukuoka University
RP Nishida, Y (corresponding author), Saga Univ, Dept Prevent Med, Fac Med, Saga, Japan.
EM ynishida@cc.saga-u.ac.jp
RI Nishida, Yuichiro/H-8791-2019
OI Nishida, Yuichiro/0000-0003-2320-7234; Hara, Megumi/0000-0002-8708-3237
FU Japanese Ministry of Education, Culture, Sports, Science, and Technology
   [19200049]; Global FU Program; Fukuoka University; Grants-in-Aid for
   Scientific Research [19200049] Funding Source: KAKEN
FX We thank all of the subjects for participating in the study. We also
   thank Dr. Hideaki Kumahara and Hiroyuki Higuchi for workload correction
   of electric cycle ergometry. This work was partially supported by grants
   from the Japanese Ministry of Education, Culture, Sports, Science, and
   Technology (No. 19200049, Strategic Research Infrastructure) and the
   Global FU Program, funded by Fukuoka University.
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NR 49
TC 27
Z9 28
U1 0
U2 16
PU JAPAN SOC INTERNAL MEDICINE
PI TOKYO
PA 34-3 3-CHOME HONGO BUNKYO-KU, TOKYO, 113, JAPAN
SN 0918-2918
EI 1349-7235
J9 INTERNAL MED
JI Intern. Med.
PY 2011
VL 50
IS 19
BP 2121
EP 2128
DI 10.2169/internalmedicine.50.5506
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 835AO
UT WOS:000296005800007
PM 21963729
OA hybrid
DA 2025-06-11
ER

PT J
AU Park, JH
   Ahn, J
   Kim, S
   Kwon, DY
   Ha, TY
AF Park, Jae-Ho
   Ahn, Jiyun
   Kim, Suna
   Kwon, Dae Young
   Ha, Tae Youl
TI Murine hepatic miRNAs expression and regulation of gene expression in
   diet-induced obese mice
SO MOLECULES AND CELLS
LA English
DT Article
DE gene expression; high-fat diet; microRNA; miRNA array; obesity
ID METABOLIC SYNDROME; MICRORNA EXPRESSION; OXIDATIVE STRESS;
   LIPID-METABOLISM; NATIVE JAPANESE; STEATOHEPATITIS; HYPERTENSION;
   CHOLESTEROL; DYSFUNCTION; PREVALENCE
AB MicroRNAs are short, non-coding RNA molecules that regulate gene expression primarily by translational repression or by messenger RNA degradation. MicroRNAs play crucial roles in various biological processes. However, little is known regarding their role in obesity. We investigated differences of microRNA (miRNA) expression in liver tissue from diet-induced obese mice and potential effects of them on gene and protein expression. We used a miRNA microarray and quantitative RT-PCR to determine miRNA expression in murine liver tissue. Gene and protein expression were determined by qRT-PCR and Western blot analysis. Effects of miRNA by knock-down using RNAi or overexpression on putative target genes and/or proteins in a murine hepatic cell line were also investigated. MicroRNA array and qRT-PCR analsysis revealed that > 50 miRNAs were down- or upregulated more than 2-fold in the liver of diet-induced obese mice. While changes in expression of many genes were observed at the mRNA level, some were only altered at the protein level. Overexpression or knock-down of miR-107 in murine hepatic cells revealed that the expression of its putative target, fatty acid synthase, was dramatically decreased or increased, respectively. In conclusion, more than 50 hepatic miRNAs were dysregulated in diet-induced obese mice. Some of them regulate protein expression at translation level and others regulate mRNA expression at transcriptional level. MiR-107 is downregulated while FASN, a putative target of miR-107, was increased in diet-induced obese mice. These findings provide the evidence of the correlation of miRNAs and their targets in diet-induced obese mice.
C1 [Park, Jae-Ho; Ahn, Jiyun; Kim, Suna; Kwon, Dae Young; Ha, Tae Youl] Korea Food Res Inst, Songnam 463746, South Korea.
C3 Korea Food Research Institute (KFRI)
RP Ha, TY (corresponding author), Korea Food Res Inst, Songnam 463746, South Korea.
EM tyhap@kfri.re.kr
RI Kwon, Dae Young/IXD-9511-2023; Lee, Ki/M-4114-2018
FU Korea Food Research Institute
FX This work was supported by grant from the Korea Food Research Institute.
   The authors declare no conflict of interest.
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NR 31
TC 32
Z9 34
U1 1
U2 15
PU KOREAN SOC MOLECULAR & CELLULAR  BIOLOGY
PI SEOUL
PA 635-4, YUCKSAM-DONG, GANGNAM-GU, SEOUL 135-703, SOUTH KOREA
SN 1016-8478
EI 0219-1032
J9 MOL CELLS
JI Mol. Cells
PD JAN
PY 2011
VL 31
IS 1
BP 33
EP 38
DI 10.1007/s10059-011-0009-7
PG 6
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA 741YQ
UT WOS:000288904200005
PM 21120623
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Genest, J
AF Genest, Jacques
TI C-reactive protein: Risk factor, biomarker and/or therapeutic target?
SO CANADIAN JOURNAL OF CARDIOLOGY
LA English
DT Article; Proceedings Paper
CT Symposium on Advances in Vascular Biology
CY AUG 13-16, 2009
CL Vancouver, CANADA
DE C-reactive protein; Cardiovascular risk; Guidelines; Prevention; Statins
ID GLOBAL CARDIOVASCULAR RISK; EARLY ATHEROSCLEROSIS; METABOLIC SYNDROME;
   DISEASE; PREDICTION; INFLAMMATION; CHOLESTEROL; PREVENTION; GUIDELINES;
   EVENTS
AB The inflammatory biomarker high-sensitivity C-react we protein (hsCRP) has been proposed is a novel instrument to assess cardiovascular risk, to determine the need for stain therapy in specific individuals otherwise not deemed to meet current criteria, and to represent a potential target of treatment. CRP is predominantly secreted by the liver and adipose tissue in response to inflammatory stress and is regulated, in great part, by interleukin-6. The issue of CRP MS a causal factor (rather than a biomarker) has been addressed by three types of studies: animal models, in which CRP was injected; transgenic to ice over-expressing human CRP; and Mendelian randomization studies. All indicate that CRP may not have a direct role in Promoting atherosclerosis hut, instead, serves is a marker of vascular inflammation and the presence of atherosclerosis. Several clinical studies have shown that individuals reaching both low-density lipoprotein cholesterol (LDL-C) and is a,RP targets (LDL-C less than 2.0 mmol/L and hsCRP less than 2 mg/L) have the lowest event rate, suggesting that CRP may become a secondary target of treatment after LPL-C. The Justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuviistatin (JUPITER) study showed that apparently healthy men and woolen with elevated hsCRP, but normal LDL-C (less than 3.4 mmol/L), had an overall 44% reduction in the primary end points with rosuvastatin 20 mg/day. The results of this study have now been incorporated in the new Canadian guidelines for the diagnosis and treatment of dyslipidemia and prevention of cardiovascular disease.
C1 [Genest, Jacques] McGill Univ, Montreal, PQ H3A 1A1, Canada.
C3 McGill University
RP Genest, J (corresponding author), McGill Univ, Royal Victoria Hosp, Ctr Hlth, Fac Med,Novartis Chair Med,Div Cardiol, 687 Pine Ave W, Montreal, PQ H3A 1A1, Canada.
EM Jacques.genest@muhc.mcgill.ca
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NR 30
TC 72
Z9 82
U1 0
U2 10
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0828-282X
EI 1916-7075
J9 CAN J CARDIOL
JI Can. J. Cardiol.
PD MAR
PY 2010
VL 26
SU A
BP 41A
EP 44A
DI 10.1016/S0828-282X(10)71061-8
PG 4
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Cardiovascular System & Cardiology
GA 580EX
UT WOS:000276431200010
PM 20386760
DA 2025-06-11
ER

PT J
AU Knoops, AJG
   van der Graaf, Y
   Mali, WPTM
   Geerlings, MI
AF Knoops, Arnoud J. G.
   van der Graaf, Yolanda
   Mali, Willem P. Th. M.
   Geerlings, Mirjam I.
TI Age-related changes in hypothalamic-pituitary-adrenal axis activity in
   patients with manifest arterial disease
SO ENDOCRINE
LA English
DT Article
DE HPA axis; Age; Salivary cortisol; Circadian rhythm; Dexamethasone
   suppression test
ID CORTISOL RESPONSE; CARDIOVASCULAR-DISEASE; FEEDBACK SENSITIVITY;
   METABOLIC SYNDROME; PLASMA-CORTISOL; DEXAMETHASONE; STRESS; HUMANS;
   SYSTEM; PREDICTOR
AB Reports on age-related changes of hypothalamic-pituitary-adrenal (HPA) axis activity are equivocal. In addition, subtle changes in HPA axis activity are associated with cardiovascular risk factors. This study evaluates the effect of age in a large sample of patients with arterial disease on several parts of the circadian rhythm of the HPA axis. Within the Second Manifestations of Arterial Disease-Magnetic Resonance (SMART-MR) study, a prospective cohort study among patients with manifest arterial disease, cross-sectional analyses were performed in 419 patients (age 63 +/- A 9 years). Circadian cortisol rhythm was assessed with six saliva samples, collected at awakening and 30, 45, and 60 min thereafter and at 10 and 11 pm. Furthermore, a low dose of dexamethasone (0.5 mg) was administered at 11 pm, and saliva was sampled the next morning to test the cortisol suppression. Linear regression analyses adjusted for sex, awakening time, workday, smoking, blood pressure, BMI, diabetes mellitus, and dyslipidemia showed that older age was associated with a blunted cortisol awakening response. Per year increase, the rise (beta = -0.15 nmol/l; 95%CI -0.25 to -0.05) and diurnal pattern (beta = -0.14 nmol/l; 95%CI -0.25 to -0.02) decreased. Furthermore, older age was associated with higher evening levels (beta log transformed = 0.01; 95%CI 0.01-0.02) and higher mean cortisol after dexamethasone (beta log transformed = 0.01; 95%CI 0.002-0.02). In patients with arterial disease, HPA axis activity showed reduced variability with older age, independent of cardiovascular risk factors.
C1 [Knoops, Arnoud J. G.; van der Graaf, Yolanda; Geerlings, Mirjam I.] Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, NL-3508 GA Utrecht, Netherlands.
   [Mali, Willem P. Th. M.] Univ Med Ctr Utrecht, Dept Radiol, NL-3508 GA Utrecht, Netherlands.
C3 Utrecht University; Utrecht University Medical Center; Utrecht
   University; Utrecht University Medical Center
RP Geerlings, MI (corresponding author), Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Stratenum 6-131,POB 85500, NL-3508 GA Utrecht, Netherlands.
EM m.geerlings@umcutrecht.nl
RI Mali, Willem/I-1123-2014; Geerlings, Mirjam I./F-4087-2015
OI Geerlings, Mirjam I./0000-0002-4037-036X
FU Netherlands Organization for Scientific Research-Medical Sciences
   (NWO-MW) [904-65-095]; Netherlands Organization for Scientific Research
   (NWO) [917-66-311]; Internationale Stichting Alzheimer Onderzoek
FX Supported by a program grant from the Netherlands Organization for
   Scientific Research-Medical Sciences (NWO-MW: project no. 904-65-095); a
   VIDI grant from the Netherlands Organization for Scientific Research
   (NWO: project no. 917-66-311); and the Internationale Stichting
   Alzheimer Onderzoek. The funding sources had no involvement in the
   writing of this article or in the decision to submit it for publication.
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NR 32
TC 18
Z9 18
U1 0
U2 8
PU HUMANA PRESS INC
PI TOTOWA
PA 999 RIVERVIEW DRIVE SUITE 208, TOTOWA, NJ 07512 USA
SN 1355-008X
EI 1559-0100
J9 ENDOCRINE
JI Endocrine
PD FEB
PY 2010
VL 37
IS 1
BP 231
EP 238
DI 10.1007/s12020-009-9291-y
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 546YP
UT WOS:000273851800030
PM 20963575
DA 2025-06-11
ER

PT J
AU Abdul-Ghani, MA
   Jani, R
   Chavez, A
   Molina-Carrion, M
   Tripathy, D
   DeFronzo, RA
AF Abdul-Ghani, M. A.
   Jani, R.
   Chavez, A.
   Molina-Carrion, M.
   Tripathy, D.
   DeFronzo, R. A.
TI Mitochondrial reactive oxygen species generation in obese non-diabetic
   and type 2 diabetic participants
SO DIABETOLOGIA
LA English
DT Article
DE ATP synthesis; Insulin resistance; Mitochondria; Reactive oxygen
   species; Type 2 diabetes
ID INCREASED OXIDATIVE STRESS; INSULIN-RESISTANCE; SKELETAL-MUSCLE;
   METABOLIC SYNDROME; DYSFUNCTION; PHOSPHORYLATION; SUPEROXIDE; MELLITUS;
   MEN
AB The aim of this study was to measure mitochondrial reactive oxygen species (ROS) production directly from skeletal muscle biopsies obtained from obese insulin-resistant non-diabetic and type 2 diabetic participants.
   Ten lean healthy, ten obese non-diabetic and ten type 2 diabetic participants received a euglycaemic-hyperinsulinaemic clamp to measure whole body insulin sensitivity. Mitochondria were isolated from skeletal muscle biopsies, and mitochondrial ATP synthesis and hydrogen peroxide production were measured ex vivo under conditions that maximally stimulate ATP synthesis and ROS production using chemiluminescent and fluorescent techniques, respectively.
   Compared with lean controls, both obese non-diabetic and type 2 diabetic participants were resistant to insulin, and had a reduced rate of mitochondrial ATP production. Obese insulin-resistant participants had a decreased rate of mitochondrial ROS production, while ROS production rate in participants with type 2 diabetes was similar to that in lean healthy participants. In non-diabetic participants, the rate of ROS production was strongly correlated with the rate of ATP synthesis and the glucose disposal rate measured with the euglycaemic-hyperinsulinaemic clamp. The ROS/ATP ratio in obese insulin-resistant participants was similar to that in lean insulin-sensitive participants, while the ratio was significantly elevated in type 2 diabetes participants.
   Since, in absolute terms, the maximal capacity for mitochondrial ROS production was not increased in either obese insulin-resistant participants or in type 2 diabetic participants, these results do not favour a role for increased mitochondrial ROS production in the pathogenesis of insulin resistance in human skeletal muscle. However, care should be taken in extrapolating these ex vivo observations to the in vivo situation.
C1 [Abdul-Ghani, M. A.; Jani, R.; Chavez, A.; Molina-Carrion, M.; Tripathy, D.; DeFronzo, R. A.] Univ Texas Hlth Sci Ctr San Antonio, Diabet Div, San Antonio, TX 78229 USA.
C3 University of Texas System; University of Texas Health Science Center at
   San Antonio
RP Abdul-Ghani, MA (corresponding author), Univ Texas Hlth Sci Ctr San Antonio, Diabet Div, 7703 Floyd Curl Dr MS 7886, San Antonio, TX 78229 USA.
EM Abdulghani@uthscsa.edu
FU NIH [24092]; VA Merit Award; GCRC [RR01346]
FX We would like to thank our GCRC nurses for their assistance in
   performing these studies and K. Delgado and L. Albarado ( University of
   Texas Health Center at San Antonio) for their help in preparing the
   manuscript. This work was supported by NIH grant 24092, a VA Merit Award
   ( R. A. DeFronzo) and GCRC grant RR01346.
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NR 35
TC 72
Z9 86
U1 0
U2 6
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0012-186X
EI 1432-0428
J9 DIABETOLOGIA
JI Diabetologia
PD APR
PY 2009
VL 52
IS 4
BP 574
EP 582
DI 10.1007/s00125-009-1264-4
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 413IR
UT WOS:000263787300004
PM 19183935
OA Bronze
DA 2025-06-11
ER

PT J
AU Musso, G
   Gambino, R
   Pacini, G
   Pagano, G
   Durazzo, M
   Cassader, M
AF Musso, Giovanni
   Gambino, Roberto
   Pacini, Giovanni
   Pagano, Gianfranco
   Durazzo, Marilena
   Cassader, Maurizio
TI Transcription Factor 7-Like 2 Polymorphism Modulates Glucose and Lipid
   Homeostasis, Adipokine Profile, and Hepatocyte Apoptosis in NASH
SO HEPATOLOGY
LA English
DT Article
ID FATTY LIVER-DISEASE; BETA-CELL FUNCTION; TRANSCRIPTION-FACTOR-7-LIKE-2
   TCF7L2 GENE; SERUM ALANINE AMINOTRANSFERASE; INSULIN SENSITIVITY;
   METABOLIC SYNDROME; OXIDATIVE STRESS; ADIPOSE-TISSUE; RISK;
   STEATOHEPATITIS
AB Genetic factors underlying the association of NAFLD with diabetes and atherosclerosis are unknown. Recent human studies suggest transcription factor 7-like 2 (TCF7L2) polymorphism. predisposes to diabetes through modulation of P-cell function and modulates lipid levels in familial dyslipidemia. Emerging experimental evidence connects TCF7L2 to adipocyte metabolism and lipid homeostasis, as well. We tested if TCF7L2 polymorphism is a risk factor for nonalcoholic fatty liver disease (NAFLD) and if it modulates liver injury, glucose homeostasis, lipoprotein, and adipokine profiles in NASH. TCF7L2 genotype and dietary habits of 78 nondiabetic normolipidemic NAFLD subjects and 156 age-, body mass index-, sex-matched healthy controls were assessed. In 39 biopsy-proven nonalcoholic steatohepatitis (NASH) and matched controls TCF7L2 polymorphism was correlated to liver histology and oral glucose tolerance test-derived parameters of glucose homeostasis. Patients with NASH and controls consumed a high-fat meal and TCF7L2 genotype was correlated to postprandial circulating lipoproteins, adipokines, and cytokeratin-18 fragments. The TCF7L2 CT/TT genotype was more frequent in NAFLD and predicted the presence and severity of liver disease, of P-cell dysfunction, of reduced incretin effect and hepatic insulin resistance in NASH; it also modulated postprandial hepatocyte apoptosis, lipoproteins, and adipokine profiles in both groups. Conclusion TCF7L2 polymorphism predisposes to NAFLD and significantly impacts liver injury, glucose homeostasis, and postprandial lipoprotein and adipokine responses to fat ingestion. This polymorphism also modulates a fat-induced increase in circulating markers of hepatocyte apoptosis in NASH. Targeting postprandial lipemia, at least in at-risk TCF7L2 genotypes, may improve liver disease and glucose dysmetabolism in these patients. (HEPATOLOGY 2009;49:426-435.)
C1 [Musso, Giovanni] Gradenigo Hosp, I-10132 Turin, Italy.
   [Gambino, Roberto; Pagano, Gianfranco; Durazzo, Marilena; Cassader, Maurizio] Univ Turin, Dept Internal Med, I-10124 Turin, Italy.
   [Pacini, Giovanni] CNR, Metab Unit, Inst Biomed Engn, Padua, Italy.
C3 Humanitas Hospital Gradenigo; University of Turin; Consiglio Nazionale
   delle Ricerche (CNR)
RP Musso, G (corresponding author), Gradenigo Hosp, Corso Regina Margherita 8, I-10132 Turin, Italy.
EM giovanni_musso@yahoo.it
RI Musso, Giovanni/AAB-7884-2022; GAMBINO, Roberto/AAC-7517-2022
OI DURAZZO, Marilena/0000-0003-2450-5911
FU Piedmont Region Funds Comitato Interministerial per la Programmazione
   Economica
FX Supported in part by the Piedmont Region Funds Comitato Interministerial
   per la Programmazione Economica 2008.
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NR 42
TC 72
Z9 80
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0270-9139
EI 1527-3350
J9 HEPATOLOGY
JI Hepatology
PD FEB
PY 2009
VL 49
IS 2
BP 426
EP 435
DI 10.1002/hep.22659
PG 10
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 401EW
UT WOS:000262923300014
PM 19105201
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Tomiyama, H
   Okazaki, R
   Inoue, D
   Ochiai, H
   Shiina, K
   Takata, Y
   Hashimoto, H
   Yamashina, A
AF Tomiyama, H.
   Okazaki, R.
   Inoue, D.
   Ochiai, H.
   Shiina, K.
   Takata, Y.
   Hashimoto, H.
   Yamashina, A.
TI Link between obstructive sleep apnea and increased bone resorption in
   men
SO OSTEOPOROSIS INTERNATIONAL
LA English
DT Article
DE bone metabolic markers; hypoxia; osteopenia; sleep apnea
ID POSITIVE AIRWAY PRESSURE; MINERAL DENSITY; CARDIOVASCULAR OUTCOMES;
   METABOLIC SYNDROME; BLOOD-PRESSURE; HYPOXIA; DIFFERENTIATION;
   OSTEOPOROSIS; PATHOGENESIS; PREVALENCE
AB The bone metabolic abnormalities in patients with obstructive sleep apnea (OSA) were examined. Severity-dependent increases in the serum/urinary levels of bone resorption markers and their attenuation following continuous positive airway pressure therapy in subjects with OSA provide the first evidence of a link between OSA and abnormal bone metabolism.
   Introduction Hypoxia, microinflammation and oxidative stress, well-known pathophysiological features of obstructive sleep apnea (OSA), are also known to affect bone metabolism. We examined the bone metabolic abnormalities in patients with OSA and also the effects of continuous positive airway pressure (CPAP) therapy on these abnormalities.
   Methods A cross-sectional and prospective study was conducted in 50 consecutive male subjects visiting a sleep clinic and 15 age-matched control subjects without OSA. Plasma concentrations of IL-1 beta, IL-6, TNF-alfa, 3-nitrotyrosine, osteocalcin, bone-specific alkaline phosphatase (BAP), and urinary concentrations of cross-linked C-terminal telopeptide of type I collagen (CTX) were examined before and after 3 months' CPAP in subjects with OSA.
   Results The plasma levels of the cytokines as well as the urinary CTX levels were higher in subjects with severe OSA than in those with mild OSA or control subjects. Significant decrease of the urinary excretion of CTX (before: 211 +/- 107 vs. after: 128 +/- 59 mu g/mmol/creatinine; p<0.01) as well as of the plasma levels of the cytokines was observed following 3 months' CPAP.
   Conclusions Severity-dependent increases in the serum/urinary levels of bone resorption markers and their reversal following CPAP in subjects with OSA provide the first evidence of a link between OSA and abnormal bone metabolism.
C1 [Tomiyama, H.; Shiina, K.; Takata, Y.; Yamashina, A.] Tokyo Med Univ, Dept Internal Med 2, Shinjuku Ku, Tokyo 1600023, Japan.
   [Okazaki, R.; Inoue, D.; Ochiai, H.] Teikyo Univ, Chiba Med Ctr, Dept Internal Med 3, Tokyo 173, Japan.
   [Hashimoto, H.] Univ Tokyo, Grad Sch Med, Tokyo, Japan.
C3 Tokyo Medical University; Teikyo University; University of Tokyo
RP Yamashina, A (corresponding author), Tokyo Med Univ, Dept Internal Med 2, Shinjuku Ku, 6-7-1 Nishi Shinjuku, Tokyo 1600023, Japan.
EM tomiyama@tokyo-med.ac.jp
OI Shiina, Kazuki/0000-0002-7293-2064; Hashimoto,
   Hideki/0000-0003-3663-6564
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NR 39
TC 72
Z9 79
U1 0
U2 4
PU SPRINGER LONDON LTD
PI LONDON
PA 236 GRAYS INN RD, 6TH FLOOR, LONDON WC1X 8HL, ENGLAND
SN 0937-941X
EI 1433-2965
J9 OSTEOPOROSIS INT
JI Osteoporosis Int.
PD AUG
PY 2008
VL 19
IS 8
BP 1185
EP 1192
DI 10.1007/s00198-007-0556-0
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 322NK
UT WOS:000257382400011
PM 18224268
DA 2025-06-11
ER

PT J
AU Balaban, YH
   Korkusuz, P
   Simsek, H
   Gokcan, H
   Gedikoglu, G
   Pinar, A
   Hascelik, G
   Asan, E
   Hamaloglu, E
   Tatar, G
AF Balaban, Yasemin H.
   Korkusuz, Petek
   Simsek, Halis
   Gokcan, Hale
   Gedikoglu, Gokhan
   Pinar, Ash
   Hascelik, Gulsen
   Asan, Esin
   Hamaloglu, Erhan
   Tatar, Gonca
TI Dipeptidyl peptidase IV (DDP IV) in NASH patients
SO ANNALS OF HEPATOLOGY
LA English
DT Article
DE CD26; dipeptidyl peptidase IV; non-alcoholic steatohepatitis; metabolic
   syndrome
ID NONALCOHOLIC STEATOHEPATITIS; LIVER-DISEASE; EXPRESSION; CD26;
   IDENTIFICATION; PATHOGENESIS; INHIBITORS; RECEPTORS; SERUM; RAT
AB Objective(s): Non-alcoholic steatohepatitis (NASH) is a chronic liver disease with unknown etiology. The insulin resistance, immune mechanisms and oxidative stress are the main factors in its pathogenesis. Dipeptidyl peptidase IV (DPPIV) or CD26 is a protein with endocrine and immune functions. This study aimed to elicudate the changes related to DPPIV in NASH patients. Methods: Serum and urinary DPPIV activities were measured in 31 NASH patients and 17 healthy controls. The liver biopsies of 29 patients were immunolabeled for CD26. Results: The mean age of patients were 46 +/- 11 years and 14 (45%) of them were female. The serum DPPIV activity was higher in patients (57.3 +/- 7.8 U/L) than controls (43.6 +/- 10.6 U/L) (p < 0.0001), and correlated with the histopathological grade (p = 0.038, r = 0.373) and hepatosteatosis (p = 0.018, r = 0.423) but not with stage (p = 0.286), class (p = 0.286) or CD26 staining (p = 0.743). The urinary DPPIV activity was similar in patients (1.52 +/- 0.94 U/mmol creatinine) and controls (1.37 +/- 0.68 U/mmol creatinine) (p = 0.861). Three acinar zones of liver had equal CD26 expression (p = 0.076). The intensity of CD26 immunostaining was correlated with histopathological grade (p = 0.001) and hepatosteatosis (p = 0.003) but no correlation with stage or class could be detected (p = 0.610 and 0.956, respectively). In Conclusions: The serum DPPIV activity and the staining intensity of CD26 in liver are correlated with histopathologic grade of NASH and hepatosteatosis. DPPIV can be proposed as a novel candidate with several potential functions in NASH pathogenesis.
C1 [Balaban, Yasemin H.; Simsek, Halis; Tatar, Gonca] Abant Izzet Baysal Univ, Izzet Baysal Fac Med, Dept Internal Med, Div Gastroenterol, Bolu, Turkey.
   [Korkusuz, Petek; Asan, Esin] Hacettepe Univ, Dept Histol & Embryol, Ankara, Turkey.
   [Gokcan, Hale] Baskent Univ, Div Gastroenterol, Dept Internal Med, TR-06490 Ankara, Turkey.
   [Gedikoglu, Gokhan] Hacettepe Univ, Dept Pathol, Ankara, Turkey.
   [Pinar, Ash] Hacettepe Univ, Childrens Hosp, Clin Chem Lab, Ankara, Turkey.
   [Hascelik, Gulsen] Hacettepe Univ, Dept Microbiol & Clin Microbiol, Ankara, Turkey.
   [Hamaloglu, Erhan] Hacettepe Univ, Dept Gen Surg, Ankara, Turkey.
C3 Abant Izzet Baysal University; Hacettepe University; Baskent University;
   Hacettepe University; Hacettepe University; Hacettepe University;
   Hacettepe University
RP Balaban, YH (corresponding author), Abant Izzet Baysal Univ, Izzet Baysal Fac Med, Dept Internal Med, Div Gastroenterol, Bolu, Turkey.
EM ybalaban@superonline.com
RI Balaban, Yasemin/K-4930-2019; SIMSEK, HALIS/I-9259-2013; KORKUSUZ,
   PETEK/JCD-9195-2023; HASCELIK, AYSE/I-8361-2013; Gökcan,
   Hale/AAR-8893-2020
OI Gokcan, Hale/0000-0001-5663-0683; KORKUSUZ, PETEK/0000-0002-7553-3915;
   balaban, hatice yasemin/0000-0002-0901-9192
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NR 35
TC 115
Z9 145
U1 2
U2 34
PU ELSEVIER ESPANA
PI MADRID
PA CALLE DE ZURBANO, 76-4TH FLR LEFT, MADRID, 28010, SPAIN
SN 1665-2681
J9 ANN HEPATOL
JI Ann. Hepatol.
PD OCT-DEC
PY 2007
VL 6
IS 4
BP 242
EP 250
DI 10.1016/S1665-2681(19)31905-2
PG 9
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 278AZ
UT WOS:000254257100007
PM 18007554
OA hybrid
DA 2025-06-11
ER

PT J
AU Csiha, S
   Hernyák, M
   Molnár, A
   Lorincz, H
   Katkó, M
   Paragh, G
   Bodor, M
   Harangi, M
   Sztanek, F
   Berta, E
AF Csiha, Sara
   Hernyak, Marcell
   Molnar, Agnes
   Lorincz, Hajnalka
   Katko, Monika
   Paragh, Gyorgy
   Bodor, Miklos
   Harangi, Mariann
   Sztanek, Ferenc
   Berta, Eszter
TI Alpha-Lipoic Acid Treatment Reduces the Levels of Advanced End Glycation
   Products in Type 2 Diabetes Patients with Neuropathy
SO BIOMEDICINES
LA English
DT Article
DE advanced glycation end products; AGEs; sRAGE; diabetic neuropathy; alpha
   lipoic acid; atherosclerosis; oxidative stress; ADMA; progranulin
ID PERIPHERAL NEUROPATHY; METABOLIC SYNDROME; SOLUBLE RECEPTOR; THIOCTIC
   ACID; NITRIC-OXIDE; EXPRESSION; CELLS; ENDPRODUCTS; COMPLICATIONS;
   QUESTIONNAIRE
AB Background/Objectives: Type 2 diabetes mellitus (T2DM) and its macro- and microvascular complications are major health concerns with multiple factors, like advanced end glycation products (AGEs), in the background. AGEs induce long-lasting functional modification of the proteins and collagen in the vascular wall and nerve tissue. We investigated the effect of alpha-lipoic acid (ALA) treatment on AGEs, soluble AGE receptor (sRAGE), the AGE/sRAGE ratio, and the parameters of endothelial dysfunction and their correlations. Methods: In our 6-month intervention study, 54 T2DM patients with neuropathy treated according to the actual therapeutic guidelines with unchanged oral antidiabetic drugs were included and treated by daily oral administration of 600 mg ALA. A total of 24 gender and age-matched T2DM patients without neuropathy served as controls. Results: In our work, we first demonstrated the attenuating effect of alpha lipoic acid therapy on AGEs in humans (11.89 (9.44-12.88) to 10.95 (9.81-12.82) AU/mu g (p = 0.017)). sRAGE levels or the AGEs/sRAGE ratio were not affected by ALA treatment or by the presence of neuropathy. We found a correlation between the changes of AGEs and the improvement of current perception threshold and progranulin levels, and an inverse correlation with the change of asymmetric dimethylarginine. Conclusions: According to our results, ALA decreases AGEs, which may contribute to the clinically well-known beneficial effect in diabetic neuropathy and improvement of endothelial function.
C1 [Csiha, Sara; Katko, Monika; Bodor, Miklos] Univ Debrecen, Fac Med, Dept Internal Med, Div Endocrinol, H-4032 Debrecen, Hungary.
   [Csiha, Sara; Bodor, Miklos; Berta, Eszter] Univ Debrecen, Fac Pharm, Dept Clin Basics, H-4032 Debrecen, Hungary.
   [Csiha, Sara; Hernyak, Marcell; Katko, Monika; Harangi, Mariann] Univ Debrecen, Doctoral Sch Hlth Sci, H-4032 Debrecen, Hungary.
   [Hernyak, Marcell; Molnar, Agnes; Lorincz, Hajnalka; Paragh, Gyorgy; Harangi, Mariann; Sztanek, Ferenc; Berta, Eszter] Univ Debrecen, Fac Med, Dept Med, Div Metab, H-4032 Debrecen, Hungary.
C3 University of Debrecen; University of Debrecen; University of Debrecen;
   University of Debrecen
RP Sztanek, F (corresponding author), Univ Debrecen, Fac Med, Dept Med, Div Metab, H-4032 Debrecen, Hungary.
EM sztanek@belklinika.com; berta.eszter@med.unideb.hu
RI Bodor, Miklos/NJS-3545-2025; Harangi, Mariann/ACY-2278-2022
FU National Research, Development and Innovation Office-NKFIH [K142273];
   University Research Scholarship Program of the Ministry for Culture and
   Innovation from the Source of the National Research, Development and
   Innovation Fund [EKOEP-24-3-II-DE-303]
FX This research was funded by the National Research, Development and
   Innovation Office-NKFIH, grant number: K142273 project and supported by
   the EKOEP-24-3-II-DE-303 University Research Scholarship Program of the
   Ministry for Culture and Innovation from the Source of the National
   Research, Development and Innovation Fund.
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NR 65
TC 1
Z9 1
U1 0
U2 0
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2227-9059
J9 BIOMEDICINES
JI Biomedicines
PD FEB
PY 2025
VL 13
IS 2
AR 438
DI 10.3390/biomedicines13020438
PG 16
WC Biochemistry & Molecular Biology; Medicine, Research & Experimental;
   Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Research & Experimental Medicine;
   Pharmacology & Pharmacy
GA Y2O0J
UT WOS:001430570300001
PM 40002851
OA gold
DA 2025-06-11
ER

PT J
AU Sánchez-Terrón, G
   Martinez, R
   Morcuende, D
   Caballero, V
   Estévez, M
AF Sanchez-Terron, Guadalupe
   Martinez, Remigio
   Morcuende, David
   Caballero, Victor
   Estevez, Mario
TI Pomegranate supplementation alleviates dyslipidemia and the onset of
   non-alcoholic fatty liver disease in Wistar rats by shifting microbiota
   and producing urolithin-like microbial metabolites
SO FOOD & FUNCTION
LA English
DT Article
ID DIETARY FRUCTOSE; OXIDATIVE STRESS; ADIPOSE-TISSUE; BODY-WEIGHT; OBESITY
AB Non-alcoholic fatty liver disease (NAFLD), obesity and related chronic diseases are major non-communicable diseases with high mortality rates worldwide. While dietary sugars are known to be responsible for insulin resistance and metabolic syndrome (MetS), the underlying pathophysiological effects of sustained fructose consumption require further elucidation. We hypothesize that certain bioactive compounds (i.e. punicalagin and ellagic acid) from dietary pomegranate could counteract the harmful effects of sustained fructose consumption in terms of obesity and liver damage. The present study aimed to elucidate both the molecular mechanisms involved in the pathophysiology associated with fructose intake and the effect of a punicalagin-rich commercial pomegranate dietary supplement (P) used as a nutritional strategy to alleviate fructose-induced metabolic impairments. Thus, nineteen Wistar rats fed on a basal commercial feed were supplemented with either 30% (w/v) fructose in drinking water (F; n = 7) or 30% (w/v) fructose solution plus 0.2% (w/v) P (F + P; n = 6) for 10 weeks. The results were compared to those from a control group fed on the basal diet and provided with drinking water (C; n = 6). Body weight and energy intake were registered weekly. P supplementation decreased fat depots, counteracted the dyslipidemia caused by F and improved markers of liver injury including steatosis. The study of the microbiota by metagenomics and urine by untargeted MS-based metabolomics revealed microbial metabolites from P that may be responsible for these health benefits.
   Pomegranate supplemetation decreased fat depots, counteracted the dyslipidemia caused by fructose and improved markers of liver injury. Microbial metabolites from pomegranate may be responsible for these health benefits.
C1 [Sanchez-Terron, Guadalupe; Morcuende, David; Caballero, Victor; Estevez, Mario] Univ Extremadura UEXROR ID 0174shg90, Meat & Meat Prod Res Inst IPROCAR, TECAL Res Grp, Caceres 10003, Spain.
   [Martinez, Remigio] Univ Cordoba UCO ROR ID 05yc77b46, Anim Hlth Dept, Anim Hlth & Zoonoses Res Grp GISAZ, UIC Zoonosis & Emergent Dis,ENZOEM Competit Res Un, Cordoba 14014, Spain.
RP Estévez, M (corresponding author), Univ Extremadura UEXROR ID 0174shg90, Meat & Meat Prod Res Inst IPROCAR, TECAL Res Grp, Caceres 10003, Spain.
RI Sánchez-Terrón, Guadalupe/AAE-6455-2019; MORCUENDE, DAVID/D-9959-2012;
   Caballero, Víctor/HPG-9498-2023; Estevez, Mario/D-6889-2011; Martinez
   Perez, Remigio/A-2414-2009
OI Caballero, Victor/0000-0002-8464-6620; Estevez,
   Mario/0000-0002-8509-2789; Martinez Perez, Remigio/0000-0002-5908-9447
FU Junta de Extremadura [IB20103]; Ministry of Science, Innovation and
   Universities (grant: MCIN/AEI) [FPU18/01077]; Ministry of Science,
   Innovation and Universities (Guadalupe Sanchez grant) [UNEX-AE-3394];
   University of Extremadura [POSTDOC_21_00041]; University of Cordoba from
   the Consejeria de Transformacion Economica, Industria, Conocimiento y
   Universidades of the Junta de Andalucia Regional Government (Andalucia,
   Spain) [05yc77b46, 01jem9c82];  [PID2021-126193OB-I00]
FX The study was funded by "Junta de Extremadura" (IB20103), Ministry of
   Science, Innovation and Universities (grant:
   MCIN/AEI/10.13039/501100011033; project: PID2021-126193OB-I00: Guadalupe
   Sanchez grant: FPU18/01077) and the University of Extremadura
   (UNEX-AE-3394). Remigio Martinez was supported by a postdoctoral
   contract (POSTDOC_21_00041) at the University of Cordoba (ROR code
   05yc77b46) from the Consejeria de Transformacion Economica, Industria,
   Conocimiento y Universidades of the Junta de Andalucia (ROR code
   01jem9c82) Regional Government (Andalucia, Spain).
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NR 58
TC 8
Z9 8
U1 5
U2 12
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PD JUL 15
PY 2024
VL 15
IS 14
BP 7348
EP 7363
DI 10.1039/d4fo00688g
EA APR 2024
PG 16
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA YH0A3
UT WOS:001207904300001
PM 38661445
OA hybrid
DA 2025-06-11
ER

PT J
AU Habiba, E
   Ali, S
   Ghanem, Y
   Sharaki, O
   Hewedy, W
AF Habiba, Esraa
   Ali, Samia
   Ghanem, Yehia
   Sharaki, Ola
   Hewedy, Wafaa
TI Effect of oral versus parenteral vitamin D3 supplementation on nuclear
   factor-KB and platelet aggregation in type 2 diabetic patients
SO CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
LA English
DT Article
DE diabetes mellitus; NF-KB; platelet aggregation; platelet hyperactivity;
   vitamin D
ID NF-KAPPA-B; METABOLIC SYNDROME; OXIDATIVE STRESS; INSULIN; SENSITIVITY;
   ACTIVATION; MELLITUS; INFLAMMATION; INHIBITION; DISEASE
AB Platelet hyperactivity is one of the key factors implicated in the development and progression of diabetic vascular com-plications. Activated platelets mediate leukocyte recruitment that further enhances inflammatory responses in vascular wall ultimately resulting in atherosclerotic complications. Since vitamin D insufficiency is highly prevalent in diabetics, we aimed to evaluate the effect of three dosage forms of vitamin D supplementation on lipid profile, NF-KB, platelet aggregation, and platelet calcium content in type 2 diabetic patients. Type 2 diabetic patients were randomized to receive daily (4000 IU/day) or weekly (50 000 IU/week) oral vitamin D3 for 3 months. Another group received a single parenteral dose (300 000 IU) of vitamin D3, whereas the control group received their antidiabetic drug(s) alone. Serum 25(OH)D, total cholesterol, triglycerides, high-and low-density lipoprotein cholesterol, NF-KB, and platelet aggregation were measured at the beginning and 3 months after vitamin D supplementation. Platelet calcium content was evaluated by measuring the fluorescence intensity of Rhod-2-stained platelets by confocal fluorescence microscopy. Results showed that serum 25(OH)D3 levels significantly increased in all vitamin D3-treated groups. However, the mean level for parenteral treated group was significantly lower than oral-treated groups. Oral and parenteral treatment were also able to decrease NF-KB level, platelet aggregation, and platelet calcium content. However, both oral doses of vitamin D3 were superior to the single parenteral dose. In conclusion, restoring normal levels of vitamin D is an important determinant to maintain normal platelet function and reduce inflammation. Nevertheless, further long-term studies are still needed.
C1 [Habiba, Esraa; Ali, Samia; Hewedy, Wafaa] Alexandria Univ, Fac Med, Clin Pharmacol Dept, Alexandria, Egypt.
   [Ghanem, Yehia] Alexandria Univ, Fac Med, Internal Med Dept, Alexandria, Egypt.
   [Sharaki, Ola] Alexandria Univ, Fac Med, Clin Pathol Dept, Alexandria, Egypt.
C3 Egyptian Knowledge Bank (EKB); Alexandria University; Egyptian Knowledge
   Bank (EKB); Alexandria University; Egyptian Knowledge Bank (EKB);
   Alexandria University
RP Hewedy, W (corresponding author), Alexandria Univ, Fac Med, Clin Pharmacol Dept, Alexandria, Egypt.
EM wafaa.hewedy@alexmed.edu.eg
RI Hewedy, Wafaa/S-9562-2019
OI Hewedy, Wafaa/0000-0002-8287-4179
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NR 70
TC 2
Z9 2
U1 1
U2 5
PU CANADIAN SCIENCE PUBLISHING
PI OTTAWA
PA 123 Slater Street, Suite 610, OTTAWA, ON K1P 5H2, CANADA
SN 0008-4212
EI 1205-7541
J9 CAN J PHYSIOL PHARM
JI Can. J. Physiol. Pharmacol.
PD NOV
PY 2023
VL 101
IS 11
BP 610
EP 619
DI 10.1139/cjpp-2022-0359
EA SEP 2023
PG 10
WC Pharmacology & Pharmacy; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Physiology
GA JM1S7
UT WOS:001072081300001
PM 37721213
DA 2025-06-11
ER

PT J
AU Abiri, B
   Amini, S
   Hejazi, M
   Hosseinpanah, F
   Zarghi, A
   Abbaspour, F
   Valizadeh, M
AF Abiri, Behnaz
   Amini, Shirin
   Hejazi, Mahdi
   Hosseinpanah, Farhad
   Zarghi, Afshin
   Abbaspour, Faeze
   Valizadeh, Majid
TI Tea's anti-obesity properties, cardiometabolic health-promoting
   potentials, bioactive compounds, and adverse effects: A review focusing
   on white and green teas
SO FOOD SCIENCE & NUTRITION
LA English
DT Review
DE anti-obesity; cardiometabolic diseases; green tea; healthy effects;
   white tea
ID ORAL EPIGALLOCATECHIN GALLATE; TYPE-2 DIABETES-MELLITUS;
   CAMELLIA-SINENSIS; BLACK TEA; ANTIOXIDANT CAPACITY; (-)-EPIGALLOCATECHIN
   GALLATE; THERAPEUTIC PROPERTIES; MOLECULAR-MECHANISMS; METABOLIC
   SYNDROME; OXIDATIVE STRESS
AB Tea is one of the most commonly consumed beverages in the world. Morocco, Japan, and China have consumed green tea for centuries. White tea, which is a variety of green teas, is very popular in China and is highly revered for its taste. Presently, both teas are consumed in other countries around the world, even as functional ingredients, and novel research is constantly being conducted in these areas. We provide an update on the health benefits of white and green teas in this review, based on recent research done to present. After a general introduction, we focused on tea's anti-obesity and human health-promoting potential, adverse effects, and new approaches to tea and its bioactive compounds. It has been found that the health benefits of tea are due to its bioactive components, mainly phenolic compounds. Of these, catechins are the most abundant. This beverage (or its extracts) has potential anti-inflammatory and antioxidant properties, which could contribute to body weight control and the improvement of several chronic diseases. However, some studies have mentioned the possibility of toxic effects; therefore, reducing tea consumption is a good idea, especially during the last trimester of pregnancy. Additionally, new evidence will provide insight into the possible effects of tea on the human gut microbiota, and even on the viruses responsible for SARS-CoV-2. A beverage such as this may favor beneficial gut microbes, which may have important implications due to the influence of gut microbiota on human health.
C1 [Abiri, Behnaz; Hosseinpanah, Farhad; Abbaspour, Faeze; Valizadeh, Majid] Shahid Beheshti Univ Med Sci, Res Inst Endocrine Sci, Obes Res Ctr, Tehran, Iran.
   [Amini, Shirin] Shoushtar Fac Med Sci, Dept Nutr, Shoushtar, Iran.
   [Hejazi, Mahdi] Iran Univ Med Sci, Sch Publ Hlth, Dept Nutr, Tehran, Iran.
   [Zarghi, Afshin] Shahid Beheshti Univ Med Sci, Sch Pharm, Dept Pharmaceut Chem, Tehran, Iran.
C3 Shahid Beheshti University Medical Sciences; Iran University of Medical
   Sciences; Shahid Beheshti University Medical Sciences
RP Valizadeh, M (corresponding author), Shahid Beheshti Univ Med Sci, Res Inst Endocrine Sci, Obes Res Ctr, Tehran, Iran.
EM valizadeh@sbmu.ac.ir
RI Valizadeh, Majid/AAD-9338-2022; Abiri, Behnaz/AAE-6684-2022; Zarghi,
   Afshin/X-4409-2019; Abbaspour Kaboudan, Faezeh/HWL-1989-2023; Amini,
   Shirin/AAK-9123-2020; hosseinpanah, farhad/AAM-7277-2020
OI Hejazi, Mahdi/0000-0002-4382-9623
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NR 153
TC 15
Z9 15
U1 14
U2 47
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2048-7177
J9 FOOD SCI NUTR
JI Food Sci. Nutr.
PD OCT
PY 2023
VL 11
IS 10
BP 5818
EP 5836
DI 10.1002/fsn3.3595
EA AUG 2023
PG 19
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA W5EY0
UT WOS:001048746900001
PM 37823174
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Wu, TY
   Tien, N
   Lin, CL
   Cheah, YC
   Hsu, CY
   Tsai, FJ
   Fang, YJ
   Lim, YP
AF Wu, Tien-Yuan
   Tien, Ni
   Lin, Cheng-Li
   Cheah, Yu-Cun
   Hsu, Chung Y.
   Tsai, Fuu-Jen
   Fang, Yi-Jen
   Lim, Yun-Ping
TI Influence of antipsychotic medications on hyperlipidemia risk in
   patients with schizophrenia: evidence from a population-based cohort
   study and in vitro hepatic lipid homeostasis gene expression
SO FRONTIERS IN MEDICINE
LA English
DT Article
DE schizophrenia; antipsychotic medications; hyperlipidemia; cohort study;
   lipid homeostasis
ID DRUG-NAIVE PATIENTS; METABOLIC SYNDROME; DENSITY-LIPOPROTEIN; LIPASE;
   PREVALENCE; RECEPTOR; PHARMACOKINETICS; METAANALYSIS; STRESS; PLASMA
AB IntroductionSchizophrenia increases the risk of mortality and cardiovascular disease (CVD) risk. However, the correlation between antipsychotics (APs) and CVD remains controversial. Hyperlipidemia is a significant risk factor for CVD. MethodsWe conducted a nationwide population-based retrospective cohort study to investigate the effects of APs on the risk of hyperlipidemia and lipid homeostasis gene expression. We used data from the Longitudinal Health Insurance Database of Taiwan on new-onset schizophrenia patients and a comparison cohort without schizophrenia. We used a Cox proportional hazards regression model to analyze the differences in hyperlipidemia development between the two cohorts. Furthermore, we examined the effects of APs on the hepatic expression of lipid homeostasis-related genes. ResultsAfter adjusting for potential interrelated confounding factors, the case group (N = 4,533) was found to have a higher hyperlipidemia risk than the control cohort (N = 4,533) [adjusted hazard ratio (aHR), 1.30, p < 0.001]. Patients with schizophrenia without APs had a significantly higher risk of hyperlipidemia (aHR, 2.16; p < 0.001). However, patients receiving APs had a significantly lower risk of hyperlipidemia than patients not receiving APs (all aHR & LE; 0.42, p < 0.001). First-generation antipsychotics (FGAs) induce the expression of hepatic lipid catabolism genes in an in vitro model. DiscussionPatients with schizophrenia had a higher risk of hyperlipidemia than controls; however, compared with non-treated patients, AP users had a lower risk of hyperlipidemia. Early diagnosis and management of hyperlipidemia may help prevent CVD.
C1 [Wu, Tien-Yuan] Tzu Chi Univ, Grad Inst Clin Pharm, Coll Med, Hualien, Taiwan.
   [Wu, Tien-Yuan] Taichung Tzu Chi Hosp, Buddhist Tzu Chi Med Fdn, Dept Pharm, Taichung, Taiwan.
   [Tien, Ni] China Med Univ Hosp, Dept Lab Med, Taichung, Taiwan.
   [Tien, Ni] China Med Univ, Dept Med Lab Sci & Biotechnol, Taichung, Taiwan.
   [Lin, Cheng-Li] China Med Univ Hosp, Management Off Hlth Data, Taichung, Taiwan.
   [Cheah, Yu-Cun; Lim, Yun-Ping] China Med Univ, Coll Pharm, Dept Pharm, Taichung, Taiwan.
   [Hsu, Chung Y.] China Med Univ, Grad Inst Biomed Sci, Taichung, Taiwan.
   [Tsai, Fuu-Jen] China Med Univ, Coll Chinese Med, Sch Chinese Med, Taichung, Taiwan.
   [Tsai, Fuu-Jen; Lim, Yun-Ping] China Med Univ Hosp, Dept Med Res, Taichung, Taiwan.
   [Tsai, Fuu-Jen] China Med Univ, Div Med Genet, Childrens Hosp, Taichung, Taiwan.
   [Tsai, Fuu-Jen] Asia Univ, Dept Biotechnol & Bioinformat, Taichung, Taiwan.
   [Fang, Yi-Jen] Kaohsiung Med Univ, Res Ctr Environm Med, Kaohsiung, Taiwan.
   [Fang, Yi-Jen] Kaohsiung Med Univ, Coll Med, Ph D Program Environm & Occupat Med, Kaohsiung, Taiwan.
   [Fang, Yi-Jen] Natl Hlth Res Inst, Kaohsiung, Taiwan.
   [Fang, Yi-Jen] Kaohsiung Med Univ, Grad Inst Clin Med, Dept Environm Hlth, Kaohsiung, Taiwan.
   [Fang, Yi-Jen] Natl Chung Hsing Univ, Coll Med, Dept Postbaccalaureate Med, Taichung, Taiwan.
   [Fang, Yi-Jen] Show Chwan Mem Hosp, Digest Dis Ctr, Changhua, Taiwan.
   [Lim, Yun-Ping] China Med Univ Hosp, Dept Internal Med, Taichung, Taiwan.
C3 Tzu Chi University; Buddhist Tzu Chi General Hospital; Taichung Tzu Chi
   Hospital; China Medical University Taiwan; China Medical University
   Hospital - Taiwan; China Medical University Taiwan; China Medical
   University Taiwan; China Medical University Hospital - Taiwan; China
   Medical University Taiwan; China Medical University Taiwan; China
   Medical University Taiwan; China Medical University Taiwan; China
   Medical University Hospital - Taiwan; China Medical University Taiwan;
   Asia University Taiwan; Kaohsiung Medical University; Kaohsiung Medical
   University; National Health Research Institutes - Taiwan; Kaohsiung
   Medical University; National Chung Hsing University; Show Chwan Memorial
   Hospital; China Medical University Taiwan; China Medical University
   Hospital - Taiwan
RP Lim, YP (corresponding author), China Med Univ, Coll Pharm, Dept Pharm, Taichung, Taiwan.; Lim, YP (corresponding author), China Med Univ Hosp, Dept Med Res, Taichung, Taiwan.; Fang, YJ (corresponding author), Kaohsiung Med Univ, Res Ctr Environm Med, Kaohsiung, Taiwan.; Fang, YJ (corresponding author), Kaohsiung Med Univ, Coll Med, Ph D Program Environm & Occupat Med, Kaohsiung, Taiwan.; Fang, YJ (corresponding author), Natl Hlth Res Inst, Kaohsiung, Taiwan.; Fang, YJ (corresponding author), Kaohsiung Med Univ, Grad Inst Clin Med, Dept Environm Hlth, Kaohsiung, Taiwan.; Fang, YJ (corresponding author), Natl Chung Hsing Univ, Coll Med, Dept Postbaccalaureate Med, Taichung, Taiwan.; Fang, YJ (corresponding author), Show Chwan Mem Hosp, Digest Dis Ctr, Changhua, Taiwan.; Lim, YP (corresponding author), China Med Univ Hosp, Dept Internal Med, Taichung, Taiwan.
EM fang531109@gmail.com; limyp@mail2000.com.tw
RI Wu, Tien-Yuan/AAV-6964-2020; Chuang, Hung-Yi/C-9143-2009; Liao,
   Yu-Chi/AAT-1357-2021; Tsai, Fuu-Jen/J-4140-2015; Fang,
   Yi-Jen/LMQ-1660-2024
OI Fang, Yi-Jen/0009-0009-3849-7896; Lin, Cheng-Li/0000-0001-9926-3668
FU Taichung Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation
   [TTCRD112-28]; Show Chwan Memorial Hospital, Changhua, Taiwan
   [SRD-111024]; Taiwan Ministry of Health and Welfare Clinical Trial
   Center [MOHW110-TDU-B-212-124004]; China Medical University
   [CMU111-MF-34]; Ministry of Science and Technology, Taiwan, R.O.C.
   [MOST110-2320-B-039-016-MY3]; Health Data Science Center, China Medical
   University Hospital
FX The Taichung Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation
   (TTCRD112-28), Show Chwan Memorial Hospital, Changhua, Taiwan
   (SRD-111024), Taiwan Ministry of Health and Welfare Clinical Trial
   Center (MOHW110-TDU-B-212-124004), China Medical University
   (CMU111-MF-34), and the Ministry of Science and Technology, Taiwan,
   R.O.C. (MOST110-2320-B-039-016-MY3) all provided financial support for
   this study. We are appreciative of the administrative, technical, and
   financial support provided by the Health Data Science Center, China
   Medical University Hospital. The study's design, data collection, and
   analysis, publication choice, and article preparation were all done
   independently from the funders. For this investigation, no extra outside
   funding was provided.
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NR 66
TC 4
Z9 4
U1 1
U2 3
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 2296-858X
J9 FRONT MED-LAUSANNE
JI Front. Med.
PD JUN 22
PY 2023
VL 10
AR 1137977
DI 10.3389/fmed.2023.1137977
PG 14
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA L4IE6
UT WOS:001022903300001
PM 37425327
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Bril, F
   Ezeh, U
   Amiri, M
   Hatoum, S
   Pace, L
   Chen, YH
   Bertrand, F
   Gower, B
   Azziz, R
AF Bril, Fernando
   Ezeh, Uche
   Amiri, Mina
   Hatoum, Sana
   Pace, Lauren
   Chen, Yen-Hao
   Bertrand, Fred
   Gower, Barbara
   Azziz, Ricardo
TI Adipose Tissue Dysfunction in Polycystic Ovary Syndrome
SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Review
DE PCOS; hyperandrogenism; adipose tissue; fat; metabolic dysfunction;
   metabolic syndrome; miRNAs; DNA methylation; inflammation; GLUT-4;
   insulin signaling; adipokines; adiponectin; cytokines; weight loss;
   diet; exercise; thiazolidinediones; metformin; GLP-1R agonists
ID LIFE-STYLE MODIFICATION; GLYCATION END-PRODUCTS; OMENTAL FAT EXPRESSION;
   NORMAL-WEIGHT WOMEN; INSULIN-RESISTANCE; OVERWEIGHT WOMEN;
   SKELETAL-MUSCLE; ABDOMINAL FAT; OBESE WOMEN; DIETARY-COMPOSITION
AB Purpose Polycystic ovary syndrome (PCOS) is a complex genetic trait and the most common endocrine disorder of women, clinically evident in 5% to 15% of reproductive-aged women globally, with associated cardiometabolic dysfunction. Adipose tissue (AT) dysfunction appears to play an important role in the pathophysiology of PCOS even in patients who do not have excess adiposity. Methods We undertook a systematic review concerning AT dysfunction in PCOS, and prioritized studies that assessed AT function directly. We also explored therapies that targeted AT dysfunction for the treatment of PCOS. Results Various mechanisms of AT dysfunction in PCOS were identified including dysregulation in storage capacity, hypoxia, and hyperplasia; impaired adipogenesis; impaired insulin signaling and glucose transport; dysregulated lipolysis and nonesterified free fatty acids (NEFAs) kinetics; adipokine and cytokine dysregulation and subacute inflammation; epigenetic dysregulation; and mitochondrial dysfunction and endoplasmic reticulum and oxidative stress. Decreased glucose transporter-4 expression and content in adipocytes, leading to decreased insulin-mediated glucose transport in AT, was a consistent abnormality despite no alterations in insulin binding or in IRS/PI3K/Akt signaling. Adiponectin secretion in response to cytokines/chemokines is affected in PCOS compared to controls. Interestingly, epigenetic modulation via DNA methylation and microRNA regulation appears to be important mechanisms underlying AT dysfunction in PCOS. Conclusion AT dysfunction, more than AT distribution and excess adiposity, contributes to the metabolic and inflammation abnormalities of PCOS. Nonetheless, many studies provided contradictory, unclear, or limited data, highlighting the urgent need for additional research in this important field.
C1 [Bril, Fernando; Azziz, Ricardo] Univ Alabama Birmingham UAB, Heersink Sch Med, Dept Med, Birmingham, AL 35233 USA.
   [Ezeh, Uche] Calif IVF Fertil Ctr, Sacramento, CA 95833 USA.
   [Ezeh, Uche; Pace, Lauren; Azziz, Ricardo] Heersink Sch Med, Dept Obstet & Gynecol, UAB, Birmingham, AL 35233 USA.
   [Amiri, Mina] Shahid Beheshti Univ Med Sci, Res Inst Endocrine Sci, Reprod Endocrinol Res Ctr, Tehran 1516745811, Iran.
   [Hatoum, Sana] Fdn Res & Educ Excellence, Vestavia, AL 35243 USA.
   [Chen, Yen-Hao] Biomere West, Dept Res, Richmond, CA 94806 USA.
   [Bertrand, Fred] UAB, Sch Hlth Profess, Dept Clin & Diagnost Sci, Birmingham, AL 35294 USA.
   [Gower, Barbara] UAB, Sch Hlth Profess, Dept Nutr Sci, Birmingham, AL 35294 USA.
   [Azziz, Ricardo] UAB, Sch Publ Hlth, Dept Healthcare Org & Policy, Birmingham, AL 35233 USA.
   [Azziz, Ricardo] SUNY Albany, Sch Publ Hlth, Dept Hlth Policy Management & Behav, Rensselaer, NY 12144 USA.
   [Azziz, Ricardo] UAB Women & Infants Ctr, 1700 6th Ave S,Ste 10390, Birmingham, AL 35249 USA.
C3 University of Alabama System; University of Alabama Birmingham;
   University of Alabama System; University of Alabama Birmingham; Shahid
   Beheshti University Medical Sciences; University of Alabama System;
   University of Alabama Birmingham; University of Alabama System;
   University of Alabama Birmingham; University of Alabama System;
   University of Alabama Birmingham; State University of New York (SUNY)
   System; University at Albany, SUNY
RP Azziz, R (corresponding author), UAB Women & Infants Ctr, 1700 6th Ave S,Ste 10390, Birmingham, AL 35249 USA.
EM razziz@uabmc.edu
RI Chen, Yen-Hao/AAT-2339-2021; Azziz, Ricardo/N-7229-2014; Amiri,
   Mina/Y-9353-2019; Bril, Fernando/E-3430-2017; Azziz, Ricardo/B-7730-2008
OI Azziz, Ricardo/0000-0002-3917-0483
FU National Institutes of Health [1-K24-HD01346, R01-DK073632, R01-HD29364]
FX This work was supported by the National Institutes of Health (grant Nos.
   1-K24-HD01346, R01-DK073632, and R01-HD29364), an endowment from the
   Helping Hand of Los Angeles, Inc, and the Foundation for Research and
   Education Excellence, Inc (to Ricardo Azziz).
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NR 151
TC 27
Z9 28
U1 0
U2 12
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0021-972X
EI 1945-7197
J9 J CLIN ENDOCR METAB
JI J. Clin. Endocrinol. Metab.
PD JAN
PY 2024
VL 109
IS 1
BP 10
EP 24
DI 10.1210/clinem/dgad356
EA JUN 2023
PG 15
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA CZ9B7
UT WOS:001017944500001
PM 37329216
OA Bronze
DA 2025-06-11
ER

PT J
AU Whittaker, J
AF Whittaker, Joseph
TI Dietary trends and the decline in male reproductive health
SO HORMONES-INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM
LA English
DT Review
DE Fertility; Diet; Reproductive health; Testosterone; Sperm; Semen
ID SERUM TESTOSTERONE LEVELS; TRANS-FATTY-ACIDS; BODY-MASS INDEX; TYPE-2
   DIABETES-MELLITUS; REGIONAL TWINNING RATES; SPERM DNA FRAGMENTATION;
   ULTRA-PROCESSED FOODS; LEYDIG-CELL FUNCTION; SEMEN-QUALITY; INFERTILE
   MEN
AB Over the twentieth century, male reproductive health has suffered a substantial decline, as evidenced by decreases in sperm counts and testosterone levels and increases in reproductive pathologies. At the same time, the prevalence of chronic diseases such as obesity, diabetes, and metabolic syndrome has risen dramatically. Metabolic and reproductive health are highly interconnected, suggesting that their respective trends are intertwined and, given the timeframe of such trends, environmental and not genetic factors are most likely to be the primary causes. Industrialization, which began in Europe in the mid-eighteenth century, has resulted in profound changes to our diet, lifestyle, and environment, many of which are causal factors in the rise in chronic diseases. Industrialization results in a nutrition transition from an agricultural unprocessed to a modern processed diet, incorporating increases in sugar, vegetable oils, ultra-processed foods, linoleic acid, trans-fats, and total energy. This dietary shift has incurred numerous adverse effects on metabolic and reproductive health, characterized by chronic inflammation, oxidative stress, and insulin resistance. Moreover, these effects appear to multiply across subsequent generations via epigenetic inheritance. Men's fertility is markedly affected by obesity and diabetes, with an increase in total energy via processed food intake arguably being the key factor driving the diabesity pandemic. In contrast, wholefoods rich in micronutrients and phytonutrients support male fertility and a healthy body weight. Therefore, men wanting to maximize their fertility should consider making positive dietary changes, such as replacing processed foods with unprocessed foods that support metabolic and reproductive health.
C1 [Whittaker, Joseph] Univ Worcester, Sch Allied Hlth & Community, Worcester WR2 6AJ, England.
C3 University of Worcester
RP Whittaker, J (corresponding author), Univ Worcester, Sch Allied Hlth & Community, Worcester WR2 6AJ, England.
EM josephwhittaker1991@hotmail.co.uk
RI Whittaker, Joseph/HNS-5426-2023
OI Whittaker, Joseph/0000-0002-4635-888X
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NR 401
TC 11
Z9 12
U1 3
U2 16
PU SPRINGER INT PUBL AG
PI CHAM
PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND
SN 1109-3099
EI 2520-8721
J9 HORM-INT J ENDOCRINO
JI Horm.-Int. J. Endocrinol. Metab.
PD JUN
PY 2023
VL 22
IS 2
BP 165
EP 197
DI 10.1007/s42000-023-00431-z
EA FEB 2023
PG 33
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA H2YZ1
UT WOS:000921708300001
PM 36725796
DA 2025-06-11
ER

PT J
AU Ruamyod, K
   Watanapa, WB
   Kakhai, C
   Nambundit, P
   Treewaree, S
   Wongsanupa, P
AF Ruamyod, Katesirin
   Watanapa, Wattana B.
   Kakhai, Chanrit
   Nambundit, Pimchanok
   Treewaree, Sukrit
   Wongsanupa, Parin
TI Ferulic acid enhances insulin secretion by potentiating L-type Ca2+
   channel activation
SO JOURNAL OF INTEGRATIVE MEDICINE-JIM
LA English
DT Article
DE Calcium channels L-type; Diabetes mellitus type 2; Ferulic acid;
   Insulin; Insulin-secreting cells; Patch-clamp techniques
ID HIGH-FAT DIET; OXIDATIVE STRESS; METABOLIC SYNDROME; CALCIUM-CHANNELS;
   IONIC CHANNELS; IN-VITRO; RELEASE; RESISTANCE; DRUGS
AB Objective: To investigate the effect of ferulic acid, a natural compound, on pancreatic beta cell viability, Ca2+ channels, and insulin secretion.Methods: We studied the effects of ferulic acid on rat insulinoma cell line viability using the 3-(4,5-dime-thylthiazol-2-yl)-2,5-diphenyltetrazolium bromide viability assay. The whole-cell patch-clamp technique and enzyme-linked immunosorbent assay were also used to examine the action of ferulic acid on Ca2+ channels and insulin secretion, respectively.Results: Ferulic acid did not affect cell viability during exposures up to 72 h. The electrophysiological study demonstrated that ferulic acid rapidly and concentration-dependently increased L-type Ca2+ chan-nel current, shifting its activation curve in the hyperpolarizing direction with a decreased slope factor, while the voltage dependence of inactivation was not affected. On the other hand, ferulic acid have no effect on T-type Ca2+ channels. Furthermore, ferulic acid significantly increased insulin secretion, an effect inhibited by nifedipine and Ca2+-free extracellular fluid, confirming that ferulic acid-induced insulin secretion in these cells was mediated by augmenting Ca2+ influx through L-type Ca2+ channel. Our data also suggest that this may be a direct, nongenomic action.Conclusion: This is the first electrophysiological demonstration that acute ferulic acid treatment could increase L-type Ca2+ channel current in pancreatic 0 cells by enhancing its voltage dependence of activa-tion, leading to insulin secretion.CO 2022 Shanghai Yueyang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine. All rights reserved.
C1 [Ruamyod, Katesirin; Watanapa, Wattana B.; Kakhai, Chanrit; Nambundit, Pimchanok; Treewaree, Sukrit; Wongsanupa, Parin] Mahidol Univ, Fac Med, Dept Physiol, Siriraj Hosp, Bangkok 10700, Thailand.
C3 Mahidol University
RP Watanapa, WB (corresponding author), Mahidol Univ, Fac Med, Dept Physiol, Siriraj Hosp, Bangkok 10700, Thailand.
EM wattana.wat@mahidol.ac.th
RI Watanapa, Wattana/R-6432-2019; Treewaree, Sukrit/GLR-2676-2022
OI Ruamyod, Katesirin/0000-0001-7382-6821; Treewaree,
   Sukrit/0000-0002-4248-2066
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TC 3
Z9 4
U1 1
U2 7
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2095-4964
J9 J INTEGR MED-JIM
JI J. Integr. Med.-JIM
PD JAN
PY 2023
VL 21
IS 1
BP 99
EP 105
DI 10.1016/j.joim.2022.11.003
EA JAN 2023
PG 7
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA H5MY5
UT WOS:000996413700001
PM 36481247
DA 2025-06-11
ER

PT J
AU Koser, F
   Hobbach, AJ
   Abdellatif, M
   Herbst, V
   Türk, C
   Reinecke, H
   Krüger, M
   Sedej, S
   Linke, WA
AF Koser, Franziska
   Hobbach, Anastasia J.
   Abdellatif, Mahmoud
   Herbst, Viktoria
   Tuerk, Clara
   Reinecke, Holger
   Krueger, Marcus
   Sedej, Simon
   Linke, Wolfgang A.
TI Acetylation and phosphorylation changes to cardiac proteins in
   experimental HFpEF due to metabolic risk reveal targets for treatment
SO LIFE SCIENCES
LA English
DT Article
DE Diastolic dysfunction; Proteomics; Obesity; Meta -inflammation;
   Myocardial stiffness
ID PRESERVED EJECTION FRACTION; HEART-FAILURE; TITIN; INFLAMMATION;
   STIFFNESS; PARADIGM
AB Aims: Despite the high prevalence of heart failure with preserved ejection fraction (HFpEF), the pathomechan-isms remain elusive and specific therapy is lacking. Disease-causing factors include metabolic risk, notably obesity. However, proteomic changes in HFpEF are poorly understood, hampering therapeutic strategies. We sought to elucidate how metabolic syndrome affects cardiac protein expression, phosphorylation and acetylation in the Zucker diabetic fatty/Spontaneously hypertensive heart failure F1 (ZSF1) rat HFpEF model, and to evaluate changes regarding their potential for treatment.Main methods: ZSF1 obese and lean rats were fed a Purina diet up to the onset of HFpEF in the obese animals. We quantified the proteome, phosphoproteome and acetylome of ZSF1 obese versus lean heart tissues by mass spectrometry and singled out targets for site-specific evaluation.Key findings: The acetylome of ZSF1 obese versus lean hearts was more severely altered (21 % of proteins changed) than the phosphoproteome (9 %) or proteome (3 %). Proteomic alterations, confirmed by immuno-blotting, indicated low-grade systemic inflammation and endothelial remodeling in obese hearts, but low nitric oxide-dependent oxidative/nitrosative stress. Altered acetylation in ZSF1 obese hearts mainly affected pathways important for metabolism, energy production and mechanical function, including hypo-acetylation of mechan-ical proteins but hyper-acetylation of proteins regulating fatty acid metabolism. Hypo-acetylation and hypo-phosphorylation of elastic titin in ZSF1 obese hearts could explain myocardial stiffening.Significance: Cardiometabolic syndrome alters posttranslational modifications, notably acetylation, in experi-mental HFpEF. Pathway changes implicate a HFpEF signature of low-grade inflammation, endothelial dysfunction, metabolic and mechanical impairment, and suggest titin stiffness and mitochondrial metabolism as promising therapeutic targets.
C1 [Koser, Franziska; Linke, Wolfgang A.] Univ Hosp Munster, Inst Physiol 2, Robert Koch Str 27b, D-48149 Munster, Germany.
   [Hobbach, Anastasia J.; Reinecke, Holger] Univ Hosp Munster, Dept Cardiol 1, Coronary Peripheral Vasc Dis & Heart Failure, D-48149 Munster, Germany.
   [Abdellatif, Mahmoud; Herbst, Viktoria; Sedej, Simon] Med Univ Graz, Dept Cardiol, Graz, Austria.
   [Tuerk, Clara; Krueger, Marcus] Inst Genet, Cologne Excellence Cluster Cellular Stress Respon, Cologne, Germany.
   [Tuerk, Clara; Krueger, Marcus] Univ Cologne, Ctr Mol Med CMMC, Cologne, Germany.
   [Sedej, Simon] BioTechMed Graz, Graz, Austria.
   [Sedej, Simon] Univ Maribor, Fac Med, Maribor, Slovenia.
C3 University of Munster; University of Munster; Medical University of
   Graz; University of Cologne; University of Cologne; University of
   Maribor
RP Linke, WA (corresponding author), Univ Hosp Munster, Inst Physiol 2, Robert Koch Str 27b, D-48149 Munster, Germany.
EM wlinke@uni-muenster.de
RI Linke, Wolfgang/IXD-9988-2023; Abdellatif, Mahmoud/AAD-5810-2019;
   Krüger, Marcus/N-8667-2019; Sedej, Simon/L-3066-2015
OI Sedej, Simon/0000-0002-4419-6821; Kruger, Marcus/0000-0002-5846-6941;
   Koser, Franziska/0009-0008-9585-0935
FU European Research Area Network on Cardiovascular Diseases (ERA-CVD)
   consortium MINOTAUR [I3301]; WAL (Bundesministerium fuer Bildung und
   Forschung); Dekanat der Medizinischen Fakultat der WWU Muenster;
   Austrian Science Fund (FWF) [I3301] Funding Source: Austrian Science
   Fund (FWF)
FX This study was supported by the European Research Area Network on
   Cardiovascular Diseases (ERA-CVD) consortium MINOTAUR to SS (The
   Austrian Science Fund-FWF, I3301) and WAL (Bundesministerium fuer
   Bildung und Forschung). AJH thanks the "Dekanat der Medizinischen
   Fakultat der WWU Muenster" for a clinician scientist grant.
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NR 51
TC 18
Z9 19
U1 1
U2 5
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0024-3205
EI 1879-0631
J9 LIFE SCI
JI Life Sci.
PD NOV 15
PY 2022
VL 309
AR 120998
DI 10.1016/j.lfs.2022.120998
EA OCT 2022
PG 11
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA 5M5DX
UT WOS:000871116700002
PM 36179815
OA hybrid
DA 2025-06-11
ER

PT J
AU Kadoglou, NPE
   Panayiotou, C
   Vardas, M
   Balaskas, N
   Kostomitsopoulos, NG
   Tsaroucha, AK
   Valsami, G
AF Kadoglou, Nikolaos P. E.
   Panayiotou, Chrystalla
   Vardas, Michail
   Balaskas, Nikolaos
   Kostomitsopoulos, Nikolaos G.
   Tsaroucha, Alexandra K.
   Valsami, Georgia
TI A Comprehensive Review of the Cardiovascular Protective Properties of
   Silibinin/Silymarin: A New Kid on the Block
SO PHARMACEUTICALS
LA English
DT Review
DE silymarin; silibinin; cardiovascular diseases; diabetes mellitus;
   hypertension; dyslipidemia
ID TYPE-2 DIABETES-MELLITUS; L. GAERTN. SILYMARIN; OXIDATIVE STRESS
   MARKERS; INDUCED CARDIOTOXICITY; METABOLIC SYNDROME; FUNCTIONAL FOODS;
   LIPID PROFILE; DOUBLE-BLIND; LONG-TERM; SILIBININ
AB Silibinin/silymarin has been used in herbal medicine for thousands of years and it is well-known for its hepato-protective properties. The present comprehensive literature review aimed to critically summarize the pharmacological properties of silymarin extract and its main ingredient silibinin in relation to classical cardiovascular risk factors (e.g., diabetes mellitus, etc.). We also assessed their potential protective and/or therapeutic application in cardiovascular diseases (CVDs), based on experimental and clinical studies. Pre-clinical studies including in vitro tests or animal models have predominantly implicated the following effects of silymarin and its constituents: (1) antioxidant, (2) hypolipidemic, (3) hypoglycemic, (4) anti-hypertensive and (5) cardioprotective. On the other hand, a direct amelioration of atherosclerosis and endothelial dysfunction after silymarin administration seems weak based on scarce data. In clinical trials, the most important findings are improved (1) glycemic and (2) lipid profiles in patients with type 2 diabetes mellitus and/or hyperlipidemia, while (3) the anti-hypertensive effects of silibinin/silymarin seem very modest. Finally, the changes in clinical endpoints are not robust enough to draw a firm conclusion. There are significant limitations in clinical trial design, including the great variety in doses and cohorts, the underlying conditions, the small sample sizes, the short duration and the absence of pharmacokinetic/pharmacodynamic tests prior to study commitment. More data from well-designed and high-quality pre-clinical and clinical studies are required to firmly establish the clinical efficacy of silibinin/silymarin and its possible therapeutic application in cardiovascular diseases.
C1 [Kadoglou, Nikolaos P. E.; Panayiotou, Chrystalla; Vardas, Michail; Balaskas, Nikolaos] Univ Cyprus, Med Sch, CY-2109 Nicosia, Cyprus.
   [Kostomitsopoulos, Nikolaos G.] Acad Athens, Biomed Res Fdn, Ctr Clin Expt Surg & Translat Res, Athens 11527, Greece.
   [Tsaroucha, Alexandra K.] Democritus Univ Thrace, Fac Med, Lab Expt Surg & Surg Res, Alexandroupolis 68100, Greece.
   [Tsaroucha, Alexandra K.] Democritus Univ Thrace, Fac Med, Lab Bioeth, Alexandroupolis 68100, Greece.
   [Valsami, Georgia] Natl & Kapodistrian Univ Athens, Sch Hlth Sci, Dept Pharm, Lab Biopharmaceut Pharmacokinet, Athens 15784, Greece.
C3 University of Cyprus; Academy of Athens; Democritus University of
   Thrace; Democritus University of Thrace; National & Kapodistrian
   University of Athens
RP Kadoglou, NPE (corresponding author), Univ Cyprus, Med Sch, CY-2109 Nicosia, Cyprus.
EM kadoglou.nikolaos@ucy.ac.cy; panayiotou.e.chrystalla@ucy.ac.cy;
   vardas.michail@ucy.ac.cy; balaskas.nikolaos@ucy.ac.cy;
   nkostom@bioacademy.gr; atsarouc@med.duth.gr; valsami@pharm.uoa.gr
RI Kadoglou, Nikolaos/AAA-8639-2021; Valsami, Georgia/AAB-4710-2020
OI Vardas, Michail/0000-0002-1306-0817; Valsami,
   Georgia/0000-0002-2395-6844; Kadoglou, Nikolaos/0000-0002-7830-3488;
   Kostomitsopoulos, Nikolaos/0000-0003-4787-5106
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NR 112
TC 24
Z9 24
U1 0
U2 17
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 1424-8247
J9 PHARMACEUTICALS-BASE
JI Pharmaceuticals
PD MAY
PY 2022
VL 15
IS 5
AR 538
DI 10.3390/ph15050538
PG 19
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 1P1IL
UT WOS:000801771300001
PM 35631363
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Kantorowicz, M
   Szymura, J
   Szygula, Z
   Kusmierczyk, J
   Maciejczyk, M
   Wiecek, M
AF Kantorowicz, Malgorzata
   Szymura, Jadwiga
   Szygula, Zbigniew
   Kusmierczyk, Justyna
   Maciejczyk, Marcin
   Wiecek, Magdalena
TI Nordic Walking at Maximal Fat Oxidation Intensity Decreases Circulating
   Asprosin and Visceral Obesity in Women With Metabolic Disorders
SO FRONTIERS IN PHYSIOLOGY
LA English
DT Article
DE asprosin; maximum fat oxidation; aerobic training; metabolic syndrome;
   abdominal obesity; body adiposity index; Nordic walking
ID BODY ADIPOSITY INDEX; INSULIN-RESISTANCE; OVERWEIGHT; INFLAMMATION;
   ADIPOKINES; STRESS
AB Objective Excess visceral adipose tissue is associated with insulin resistance and other metabolic disorders, including deregulation of adipokine secretion, which may be corrected by aerobic exercise training. Asprosin is a novel adipokine responsible for the regulation of appetite and the release of glucose from the liver, and its levels are pathologically elevated in obesity. The aim of the study was to evaluate the effects of 8-week Nordic walking (NW) training at maximal fat oxidation intensity (FAT(max)) on changes in body mass, as well as those in insulin resistance and asprosin levels among young women with visceral obesity and metabolic disorders.
   Materials and Methods The study was completed by 14 women (30.14 +/- 3.63 years) representing low levels of physical activity, visceral obesity (waist circumference 105.50 +/- 14.87 cm, BMI 33.85 +/- 5.48 kg/m(2)) and with metabolic disorders, who for 8 weeks (three times a week, 60 min), participated in NW training at the FAT(max) intensity (61.92 +/- 6.71% HRmax, 42.33 +/- 8.69% VO2max) controlled on the basis of heart rate (114.21 +/- 14.10 bpm).
   Results After 4 and 8 weeks of NW training, a significant decrease in the concentration of asprosin, waist and hip circumference (HC), waist-to-height ratio and body adiposity index (BAI) (p < 0.05, large effect size) were found.
   Conclusion The 8-week NW training at an FAT(max) intensity decreases the concentration of asprosin in the blood as well as visceral obesity in young women with metabolic disorders.
C1 [Kantorowicz, Malgorzata] Univ Sch Phys Educ Krakow, Fac Phys Educ & Sport, PhD Studies, Krakow, Poland.
   [Szymura, Jadwiga] Univ Sch Phys Educ Krakow, Fac Motor Rehabil, Dept Clin Rehabil, Krakow, Poland.
   [Szygula, Zbigniew] Univ Sch Phys Educ Krakow, Inst Biomed Sci, Fac Phys Educ & Sport, Dept Sports Med & Human Nutr, Krakow, Poland.
   [Kusmierczyk, Justyna; Maciejczyk, Marcin; Wiecek, Magdalena] Univ Sch Phys Educ Krakow, Fac Phys Educ & Sport, Dept Physiol & Biochem, Krakow, Poland.
RP Kantorowicz, M (corresponding author), Univ Sch Phys Educ Krakow, Fac Phys Educ & Sport, PhD Studies, Krakow, Poland.; Wiecek, M (corresponding author), Univ Sch Phys Educ Krakow, Fac Phys Educ & Sport, Dept Physiol & Biochem, Krakow, Poland.
EM mk.kantorowicz@gmail.com; magdalena.wiecek@awf.krakow.pl
RI Kusmerczyk, Justyna/IAP-7733-2023; Maciejczyk, Marcin/E-1211-2017;
   Wiecek, Magdalena/P-8276-2018; Szymura, Jadwiga/V-6413-2018
OI Wiecek, Magdalena/0000-0002-5390-3049; Szymura,
   Jadwiga/0000-0003-4594-7954
FU National Science Centre, Poland [2013/09/N/NZ7/01480]
FX Funding. This research was funded by the National Science Centre,
   Poland, grant number 2013/09/N/NZ7/01480. The APC was funded within the
   framework of the programme of the Ministry of Science and Higher
   Education under the name Regional Initiative for Perfection within the
   years 20192022, project No. 022/RID/2018/19 in the total of 11,919,908
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VL 12
AR 726783
DI 10.3389/fphys.2021.726783
PG 12
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA UR4GJ
UT WOS:000696709000001
PM 34539448
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Strauss, M
   Foshag, P
   Brzek, A
   Vollenberg, R
   Jehn, U
   Littwitz, H
   Leischik, R
AF Strauss, Markus
   Foshag, Peter
   Brzek, Anna
   Vollenberg, Richard
   Jehn, Ulrich
   Littwitz, Henning
   Leischik, Roman
TI Cardiorespiratory Fitness Is Associated with a Reduced Cardiovascular
   Risk in Occupational Groups with Different Working Conditions: A
   Cross-Sectional Study among Police Officers and Office Workers
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Article
DE police officer; office worker; cardiovascular prevention;
   cardiorespiratory fitness; risk profile; cardiovascular risk factors;
   cardiovascular risk
ID PHYSICAL-ACTIVITY; METABOLIC SYNDROME; SEDENTARY TIME; DISEASE RISK;
   PROGRAM; PREVALENCE; STRESS; ADULTS
AB Several studies reported a high prevalence of cardiovascular risk factors among police officers and office workers, and adequate cardiorespiratory fitness was reported to have protective effects in reducing cardiovascular risk. Therefore, the present study aimed to evaluate the effects of cardiorespiratory fitness on reducing cardiovascular risk factors in these occupational groups. This cross-sectional study enrolled 101 male participants (55 police officers and 46 office workers). Cardiorespiratory fitness was assessed via spiroergometry. Cardiovascular risk factors were also examined, and the 10-year cardiovascular risk and heart/vascular age were reported using the Framingham risk score. In both groups, higher cardiorespiratory fitness was associated with lower cardiovascular risk factors. Police officers and office workers with higher cardiorespiratory fitness demonstrated significantly lower values in BMI, waist circumference, body fat percentage, diastolic resting blood pressure, heart rate, triglycerides and total cholesterol values, and 10-year cardiovascular risk and heart/vascular age (all factors p < 0.0077, age adjusted). Police officers and office workers mostly presented low levels of cardiorespiratory fitness: 60% of police officers and 58% of office workers were considered "not fit and obese". Despite different working conditions, both occupational groups had a high rate of low cardiorespiratory fitness levels and showed no differences in their cardiovascular risk profiles. In both groups, cardiorespiratory fitness reduced cardiovascular risk factors, but there was no difference in the influence of cardiorespiratory fitness on cardiovascular risk factors.
C1 [Strauss, Markus; Foshag, Peter; Littwitz, Henning; Leischik, Roman] Univ Witten Herdecke, Sch Med, Fac Hlth, Dept Cardiol, D-58095 Hagen, Germany.
   [Strauss, Markus] Univ Hosp Muenster, Dept Cardiol Coronary & Peripheral Vasc Dis 1, Heart Failure Med, D-48149 Munster, Germany.
   [Brzek, Anna] Med Univ Silesia, Sch Hlth Sci, Dept Physiotherapy, PL-40000 Katowice, Poland.
   [Vollenberg, Richard] Univ Hosp Muenster, Dept Med Gastroenterol & Hepatol B, D-48149 Munster, Germany.
   [Jehn, Ulrich] Univ Hosp Muenster, Div Gen Internal Med Nephrol & Rheumatol, Dept Med D, D-48149 Munster, Germany.
C3 Witten Herdecke University; University of Munster; Medical University of
   Silesia; University of Munster; University of Munster
RP Strauss, M; Leischik, R (corresponding author), Univ Witten Herdecke, Sch Med, Fac Hlth, Dept Cardiol, D-58095 Hagen, Germany.; Strauss, M (corresponding author), Univ Hosp Muenster, Dept Cardiol Coronary & Peripheral Vasc Dis 1, Heart Failure Med, D-48149 Munster, Germany.
EM markus.strauss@ukmuenster.de; peter.foshag@uni-wh.de;
   aniabrzek@interia.pl; richard.vollenberg@ukmuenster.de;
   ulrich.jehn@ukmuenster.de; h.littwitz@gmx.de; roman.leischik@uni-wh.de
RI Brzęk, Anna/AEA-8696-2022
OI Brzek, Anna/0000-0002-2321-2888; Vollenberg, Richard/0000-0003-3208-7924
FU Open Access Publication Fund of the University of Muenster
FX We acknowledge support from the Open Access Publication Fund of the
   University of Muenster.
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NR 51
TC 5
Z9 5
U1 1
U2 7
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD MAY
PY 2021
VL 10
IS 9
AR 2025
DI 10.3390/jcm10092025
PG 13
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA SC1CM
UT WOS:000650418600001
PM 34065102
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Moradi, M
   Sohrabi, G
   Golbidi, M
   Yarmohammadi, S
   Hemati, N
   Campbell, MS
   Moradi, S
   Kermani, MAH
   Farzaei, MH
AF Moradi, Mozhgan
   Sohrabi, Ghazale
   Golbidi, Mojgan
   Yarmohammadi, Samira
   Hemati, Niloofar
   Campbell, Marilyn S.
   Moradi, Sajjad
   Kermani, Mohammad Ali Hojjati
   Farzaei, Mohammad Hosein
TI Effects of artichoke on blood pressure: A systematic review and
   meta-analysis
SO COMPLEMENTARY THERAPIES IN MEDICINE
LA English
DT Review
DE Artichoke supplementation; Blood pressure; Systematic review;
   Meta-analysis
ID LEAF EXTRACT SUPPLEMENTATION; DOUBLE-BLIND; BORDERLINE HYPERLIPIDEMIA;
   INSULIN-RESISTANCE; NECK CIRCUMFERENCE; METABOLIC SYNDROME; OXIDATIVE
   STRESS; CYNARA-SCOLYMUS; HYPERTENSION; TCF7L2-RS7903146
AB Purpose: Clinical trials considering the effects of artichoke supplementation on blood pressure have yielded different and contradictory outcomes. Thus, a systematic review and meta-analysis were performed to assess effects of artichoke administration on blood pressure.
   Methods: Related studies were detected by searching the Cochrane Library, PubMed, Embase and Scopus databases up to 15 March 2020. Weighted Mean Differences (WMD) were pooled using a random-effects model. Heterogeneity, sensitivity analyses, and publication bias were evaluated using standard methods.
   Results: Pooled analysis of eight randomized controlled trials revealed that artichoke supplementation did not have an effect on systolic blood pressure (SBP), (WMD: -0.77 mmHg, 95 % CI: -2.76 to 1.22) or diastolic blood pressure (DBP) (WMD: -0.11 mmHg, 95 % CI: -1.72 to 1.50) when compared to the placebo group. However, subgroup analyses based on health status suggested that artichoke administration among hypertensive patients may significantly reduce SBP (WMD: -3.19 mmHg, 95 % CI: -3.32 to -3.06) and DBP (WMD: -2.33 mmHg, 95 % CI: -2.23 to -2.43), but no such reduction was found in NAFLD patients. Furthermore, our results indicated that artichoke supplementation for 12 weeks led to a significantly decreased DBP (WMD: -2.33 mmHg, 95 % CI: -2.43 to -2.23), but 8 weeks of intervention did not (WMD: 0.80 mmHg, 95 % CI: -1.06 to 2.66).
   Conclusion: Artichoke supplementation may potentially lead to SBP and DBP reduction in hypertensive patients. In addition, artichoke supplementation for 12 weeks may significantly improve DBP.
C1 [Moradi, Mozhgan; Yarmohammadi, Samira; Hemati, Niloofar] Kermanshah Univ Med Sci, Sch Med, Internal Med Dept, Kermanshah, Iran.
   [Sohrabi, Ghazale] Isfahan Univ Med Sci, Sch Med, Esfahan, Iran.
   [Golbidi, Mojgan] Isfahan Univ Med Sci, Sch Pharm & Pharmaceut Sci, Dept Pharmacol & Toxicol, Esfahan, Iran.
   [Campbell, Marilyn S.] Univ Kentucky, Dept Kinesiol & Hlth Promot, Lexington, KY USA.
   [Moradi, Sajjad] Kermanshah Univ Med Sci, Sch Nutr Sci & Food Technol, Nutr Sci, Kermanshah, Iran.
   [Kermani, Mohammad Ali Hojjati] Shahid Beheshti Univ Med Sci, Masih Daneshvari Hosp, Clin TB & Epidemiol Res Ctr, Natl Res Inst TB & Lung Dis NRITLD, Tehran, Iran.
   [Farzaei, Mohammad Hosein] Kermanshah Univ Med Sci, Pharmaceut Sci Res Ctr, Hlth Inst, Kermanshah, Iran.
C3 Kermanshah University of Medical Sciences; Isfahan University of Medical
   Sciences; Isfahan University of Medical Sciences; University of
   Kentucky; Kermanshah University of Medical Sciences; Shahid Beheshti
   University Medical Sciences; Kermanshah University of Medical Sciences
RP Farzaei, MH (corresponding author), Kermanshah Univ Med Sci, Pharmaceut Sci Res Ctr, Hlth Inst, Kermanshah, Iran.
EM mh.farzaei@gmail.com
RI Hojjati Kermani, Mohammad ali/ABF-8543-2022; Farzaei,
   Mohammad/M-5779-2017; Moradi, Sajjad/AAX-7317-2020
OI hojjati kermani, mohammad ali/0000-0002-2364-3696; Moradi,
   Sajjad/0000-0003-0108-187X
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NR 50
TC 10
Z9 10
U1 1
U2 16
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0965-2299
EI 1873-6963
J9 COMPLEMENT THER MED
JI Complement. Ther. Med.
PD MAR
PY 2021
VL 57
AR 102668
DI 10.1016/j.ctim.2021.102668
PG 7
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA RN7VZ
UT WOS:000640562200016
PM 33465383
OA gold
DA 2025-06-11
ER

PT J
AU Hong, SW
   Lee, HJ
   Han, K
   Moon, JM
   Park, S
   Soh, H
   Kang, EA
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   Im, JP
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AF Hong, Seung Wook
   Lee, Hyun Jung
   Han, Kyungdo
   Moon, Jung Min
   Park, Seona
   Soh, Hosim
   Kang, Eun Ae
   Chun, Jaeyoung
   Im, Jong Pil
   Kim, Joo Sung
TI Risk of gastrointestinal cancer in patients with an elevated level of
   gamma-glutamyltransferase: A nationwide population-based study
SO PLOS ONE
LA English
DT Article
ID INSULIN-RESISTANCE; DIABETES-MELLITUS; OXIDATIVE STRESS; METABOLIC
   SYNDROME; ASSOCIATION; HYPERINSULINEMIA; COHORT
AB Emerging evidence that an elevated serum gamma-glutamyltransferase (GGT) level is associated with an increased risk of gastrointestinal cancer, but still controversial. The aim of this study to assess the relationship between GGT level and risk of gastrointestinal cancer, and the contribution of the interaction of hyperglycemia with elevated GGT level to the incidence of gastrointestinal cancer by the stratified analysis. A total of 8,120,665 Koreans who received medical checkups in 2009 were included. Subjects were classified according to the quartile of GGT level for women and men. The incidence rates of gastrointestinal cancer for each group were analyzed using Cox proportional hazards models. During follow-up, 129,853 cases of gastrointestinal cancer newly occurred (esophagus, 3,792; stomach, 57,932; and colorectal, 68,789 cases). The highest GGT quartile group showed an increased risk of gastrointestinal cancer (esophagus, hazard ratio = 2.408 [95% confidence interval, 2.184-2.654]; stomach, 1.121 [1.093-1.149]; and colorectal, 1.185 [1.158-1.211]). The risk increased significantly with the rise in GGT quartile level, regardless of the site of cancer. The stratified analysis according to glycemic status showed that the effect of elevated GGT was predominant in the risk of esophageal cancer. The effect of elevated GGT further increased the risk of stomach and colorectal cancers in diabetic patients. An elevated level of GGT was associated with an increased risk of gastrointestinal cancer, regardless of the site of cancer. The effect of the increase in GGT level on the risk of gastrointestinal cancer depended on the type of cancer and glycemic status.
C1 [Hong, Seung Wook; Lee, Hyun Jung; Moon, Jung Min; Park, Seona; Soh, Hosim; Kang, Eun Ae; Im, Jong Pil; Kim, Joo Sung] Seoul Natl Univ, Dept Internal Med, Coll Med, Seoul, South Korea.
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   [Chun, Jaeyoung] Yonsei Univ, Gangnam Severance Hosp, Dept Internal Med, Coll Med, Seoul, South Korea.
   [Hong, Seung Wook] Univ Ulsan, Asan Med Ctr, Dept Gastroenterol, Coll Med, Seoul, South Korea.
C3 Seoul National University (SNU); Catholic University of Korea; Yonsei
   University; Yonsei University Health System; University of Ulsan; Asan
   Medical Center
RP Lee, HJ (corresponding author), Seoul Natl Univ, Dept Internal Med, Coll Med, Seoul, South Korea.
EM guswjd80@gmail.com
RI Kang, Eun Ae/AAC-8417-2022; Kim, Jung/D-3112-2015; Soh,
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NR 41
TC 13
Z9 14
U1 0
U2 7
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD FEB 5
PY 2021
VL 16
IS 2
AR e0245052
DI 10.1371/journal.pone.0245052
PG 12
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA QH0TZ
UT WOS:000617991900020
PM 33544706
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Ousmaal, MEF
   Gaceb, A
   Khene, MA
   Ainouz, L
   Giaimis, J
   Andriantsitohaina, R
   Martínez, MC
   Baz, A
AF Ousmaal, Mohamed E. F.
   Gaceb, Abderahim
   Khene, Mhammed A.
   Ainouz, Lynda
   Giaimis, Jean
   Andriantsitohaina, Ramaroson
   Martinez, M. Carmen
   Baz, Ahsene
TI Circulating microparticles released during dyslipidemia may exert
   deleterious effects on blood vessels and endothelial function
SO JOURNAL OF DIABETES AND ITS COMPLICATIONS
LA English
DT Article
DE Dyslipidemia; High-energy diet; ICAM-1; Microparticles; Psammomys obesus
ID METABOLIC SYNDROME; MICROVESICLES; PLATELETS; DYSFUNCTION; ACTIVATION;
   STRESS; LIPIDS; DAMAGE; OXIDE
AB Aims: To compare the bioactivity of circulating microparticles (MPs) isolated from dyslipidemic Psammomys obesus (P. obesus) fed a high-energy diet (HED) with those released from healthy P. obesus fed a normal diet (ND).
   Methods: Vascular reactivity of aortic rings was evaluated by myography, after 24 h incubation in the absence or in the presence of circulating MPs isolated, by differential centrifugations, from the plasma of animals subjected to HED (MPsHED) or ND (MPsND) for 12 weeks. Human umbilical vein endothelial cells (HUVECs) were treated for 24 h with MPs(HED) or MPs(ND) animals and subjected to immunofluorescence staining of caveolin-1 (cav-1), intercellular adhesion molecule-1 (ICAM-1), endothelial nitric oxide synthase (eNOS), F-actin and reactive oxygen species (ROS) detection.
   Results: The HED exerted a distinctly pronounced hyperlipidemic effect marked by plasmatic increase of total cholesterol, low-density lipoprotein-cholesterol (LDL-C) and triglyceride (TG). Both MPs(ND) and MPs(HED) induced a significant reduction of maximal relaxation induced by acetylcholine (ACh). Interestingly, MPs(HED) significantly decreased eNOS expression up to-25% and increased ROS production up to-75% on in vitro treated HUVECs. Moreover, in HUVECs, MPs(HED) significantly decreased cav-1 expression up to-50% whereas significant increase of ICAM-1 expression by about 2-fold approximately was observed.
   Conclusion: Our experimental study demonstrated the dual role of MPs on vascular function by modulating endothelial cell function. Furthermore, MPs may be considered as vectors of a bioactive information contributing to inflammation and vascular damage. (C) 2020 Elsevier Inc. All rights reserved.
C1 [Ousmaal, Mohamed E. F.] Univ Algiers, Fac Sci, Lab Valorisat & Bioengn Nat Resources, Algiers, Algeria.
   [Ousmaal, Mohamed E. F.; Khene, Mhammed A.; Ainouz, Lynda; Baz, Ahsene] ENS Kouba, Lab Biol & Anim Physiol, Algiers, Algeria.
   [Gaceb, Abderahim] Lund Univ, Wallenberg Neurosci Ctr, Dept Clin Sci, Translat Neurol Grp, Lund, Sweden.
   [Giaimis, Jean] Univ Montpellier I, UMR Qualisud Fac Pharm, Montpellier, France.
   [Andriantsitohaina, Ramaroson; Martinez, M. Carmen] Univ Angers, SOPAM, SFR ICAT, INSERM,U1063, Bat IRIS IBS,Rue Capucins, F-49100 Angers, France.
C3 Ecole Normale Superieure de Kouba; Lund University; Universite de
   Montpellier; Universite d'Angers; Institut National de la Sante et de la
   Recherche Medicale (Inserm)
RP Ousmaal, MEF (corresponding author), Univ Algiers1, Lab Valorisat & Bioengn Nat Resources, Algiers, Algeria.
EM m.ousmall@univ-alger.dz
RI ANDRIANTSITOHAINA, Ramaroson/H-5286-2018; OUSMAAL, MOHAMED EL
   FADEL/AHC-2948-2022; Martinez, Maria Carmen/LSJ-1622-2024
OI andriantsitohaina, ramaroson/0000-0002-4770-3585; OUSMAAL, Mohamed El
   Fadel/0000-0002-6674-2782; Martinez, M Carmen/0000-0003-3897-7397;
   Lynda, AINOUZ/0000-0002-9986-9085
FU Algerian DGRSDT (The General Directorate of Scientific Research and
   Technological Development) [F04920130005]; Ministry of Higher Education
   and Scientific Research of Algeria [C3810501]; Inserm (France);
   University of Angers (France)
FX This study was supported by Algerian DGRSDT (The General Directorate of
   Scientific Research and Technological Development) [grant number
   F04920130005 to Ahsene Baz], the Ministry of Higher Education and
   Scientific Research of Algeria [grant number C3810501 to Ahsene Baz],
   the University of Angers (France) and Inserm (France). The funders had
   no role in the study design, data collection and analysis, in the
   decision to publish, or in the preparation of the manuscript.
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NR 38
TC 4
Z9 5
U1 0
U2 6
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1056-8727
EI 1873-460X
J9 J DIABETES COMPLICAT
JI J. Diabetes Complications
PD OCT
PY 2020
VL 34
IS 10
AR 107683
DI 10.1016/j.jdiacomp.2020.107683
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA NT3FY
UT WOS:000572832300008
PM 32713709
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Gohardehi, F
   Seyedin, H
   Moslehi, S
AF Gohardehi, Farzad
   Seyedin, Hesam
   Moslehi, Shandiz
TI Prevalence Rate of Diabetes and Hypertension in Disaster-Exposed
   Populations: A Systematic Review and Meta-Analysis
SO ETHIOPIAN JOURNAL OF HEALTH SCIENCES
LA English
DT Review
DE Diabetes Mellitus; Hypertension; Disasters; Natural Disasters; Patient
   Care Management
ID POSTTRAUMATIC-STRESS-DISORDER; EAST JAPAN EARTHQUAKE; ISOLATED SYSTOLIC
   HYPERTENSION; ACUTE MYOCARDIAL-INFARCTION; WORLD-TRADE-CENTER; GLOBAL
   BURDEN; METABOLIC SYNDROME; CHRONIC DISEASES; NATIONAL-HEALTH;
   BLOOD-PRESSURE
AB BACKGROUND: Non-communicable diseases (NCD) such as hypertension (HTN) and diabetes mellitus (DM) have been one of the major health problems in the world. The aim of this study was to evaluate the prevalence rate of DM and HTN following natural and man-made disasters that impose significant economic and psychological burdens on human communities.
   METHODS: In this systematic and meta-analysis review, all cross-sectional studies that at least one of their objectives was to measure the prevalence of HTN or DM in individuals affected by natural and man-made disasters were included. Literature review was done in international databases including PubMed, Scopus and Web of Science, from database inception to February 17, 2019. The extracted data included the bibliographic characteristics of the article, the age of the participants, number of participants, gender, sample size, outcome, duration of the follow-up, and prevalence of DM and HTN. Data were analyzed by STATA software (version11) and random effect method and the I2 index were used to investigate heterogeneity between the articles.
   RESULTS: A total of 16 articles met the inclusion criteria. Based on the quality assessment, 11 papers were categorized as moderate and 5 paper were categorized as high quality. The prevalence of HTN and DM in disaster-exposed populations were 47.35 (CI 95%: 38.53-56.17) and 13.56 (CI 95%: 10.12-17.01), respectively.
   CONCLUSION: The results of this study show a high prevalence of HTN and DM in survivors of major disasters, which is higher in comparison to the general population
C1 [Gohardehi, Farzad; Seyedin, Hesam] Iran Univ Med Sci, Sch Hlth Management & Informat Sci, Dept Hlth Disasters & Emergencies, Tehran, Iran.
   [Moslehi, Shandiz] Iran Univ Med Sci, Hlth Management & Econ Res Ctr, Sch Hlth Management & Informat Sci, Dept Hlth Disasters & Emergencies, Tehran, Iran.
C3 Iran University of Medical Sciences; Iran University of Medical Sciences
RP Seyedin, H (corresponding author), Iran Univ Med Sci, Sch Hlth Management & Informat Sci, Dept Hlth Disasters & Emergencies, Tehran, Iran.
EM h.seyedin@iums.ac.ir
RI Seyedin, Hesam/N-1294-2018; gohardehi, farzad/JRY-9225-2023
FU Iran University of Medical Sciences, Tehran, Iran
FX Deputy of Research and Technology, Iran University of Medical Sciences,
   Tehran, Iran
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NR 57
TC 20
Z9 22
U1 0
U2 2
PU JIMMA UNIV, ETHIOPIA
PI JIMMA
PA PO BOX 378, JIMMA, OROMIA 00000, ETHIOPIA
SN 1029-1857
EI 2413-7170
J9 ETHIOP J HEALTH SCI
JI Ethiop. J. Health Sci.
PD MAY
PY 2020
VL 30
IS 3
BP 439
EP 448
DI 10.4314/ejhs.v30i3.15
PG 10
WC Health Care Sciences & Services
WE Emerging Sources Citation Index (ESCI)
SC Health Care Sciences & Services
GA OL2QE
UT WOS:000585185800015
PM 32874087
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Johnson, RJ
   Stenvinkel, P
   Andrews, P
   Sanchez-Lozada, LG
   Nakagawa, T
   Gaucher, E
   Andres-Hernando, A
   Rodriguez-Iturbe, B
   Jimenez, CR
   Garcia, G
   Kang, DH
   Tolan, DR
   Lanaspa, MA
AF Johnson, R. J.
   Stenvinkel, P.
   Andrews, P.
   Sanchez-Lozada, L. G.
   Nakagawa, T.
   Gaucher, E.
   Andres-Hernando, A.
   Rodriguez-Iturbe, B.
   Jimenez, C. R.
   Garcia, G.
   Kang, D. -H.
   Tolan, D. R.
   Lanaspa, M. A.
TI Fructose metabolism as a common evolutionary pathway of survival
   associated with climate change, food shortage and droughts
SO JOURNAL OF INTERNAL MEDICINE
LA English
DT Review
DE fructose; metabolic syndrome; metabolic water; uric acid; vasopressin
ID URIC-ACID; OXIDATIVE STRESS; PROXIMAL TUBULE; IMMUNE-SYSTEM; BODY-WATER;
   VASOPRESSIN; EXPRESSION; CELLS; INFLAMMASOME; GLYCOGEN
AB Mass extinctions occur frequently in natural history. While studies of animals that became extinct can be informative, it is the survivors that provide clues for mechanisms of adaptation when conditions are adverse. Here, we describe a survival pathway used by many species as a means for providing adequate fuel and water, while also providing protection from a decrease in oxygen availability. Fructose, whether supplied in the diet (primarily fruits and honey), or endogenously (via activation of the polyol pathway), preferentially shifts the organism towards the storing of fuel (fat, glycogen) that can be used to provide energy and water at a later date. Fructose causes sodium retention and raises blood pressure and likely helped survival in the setting of dehydration or salt deprivation. By shifting energy production from the mitochondria to glycolysis, fructose reduced oxygen demands to aid survival in situations where oxygen availability is low. The actions of fructose are driven in part by vasopressin and the generation of uric acid. Twice in history, mutations occurred during periods of mass extinction that enhanced the activity of fructose to generate fat, with the first being a mutation in vitamin C metabolism during the Cretaceous-Paleogene extinction (65 million years ago) and the second being a mutation in uricase that occurred during the Middle Miocene disruption (12-14 million years ago). Today, the excessive intake of fructose due to the availability of refined sugar and high-fructose corn syrup is driving 'burden of life style' diseases, including obesity, diabetes and high blood pressure.
C1 [Johnson, R. J.; Andres-Hernando, A.; Jimenez, C. R.; Garcia, G.; Lanaspa, M. A.] Univ Colorado Anschutz Med Campus, Div Renal Dis & Hypertens, 12700 East 19th Ave,Bldg RC2,Room 7012,Mail Stop, Aurora, CO 80045 USA.
   [Stenvinkel, P.] Karolinska Inst, Div Renal Dis, Stockholm, Sweden.
   [Andrews, P.] Museum Nat Hist, London, England.
   [Sanchez-Lozada, L. G.; Rodriguez-Iturbe, B.] INC Ignacio Chavez, Dept Nephrol, Mexico City, DF, Mexico.
   [Nakagawa, T.] Rakuwakai Otowa Hosp, Dept Nephrol, Kyoto, Japan.
   [Gaucher, E.] Georgia State Univ, Dept Biol, Atlanta, GA 30303 USA.
   [Kang, D. -H.] Ewha Womans Univ, Div Renal Dis, Seoul, South Korea.
   [Tolan, D. R.] Boston Univ, Dept Biol, 5 Cummington St, Boston, MA 02215 USA.
C3 University of Colorado System; University of Colorado Anschutz Medical
   Campus; Karolinska Institutet; Natural History Museum London; University
   System of Georgia; Georgia State University; Ewha Womans University;
   Boston University
RP Johnson, RJ (corresponding author), Univ Colorado Anschutz Med Campus, Div Renal Dis & Hypertens, 12700 East 19th Ave,Bldg RC2,Room 7012,Mail Stop, Aurora, CO 80045 USA.
EM Richard.Johnson@ucdenver.edu
RI Sanchez-Lozada, Laura/AAS-2104-2021; Rodriguez-Iturbe,
   Bernardo/KFX-2910-2024; Lanaspa, Miguel/AAO-4971-2020
OI Andres-Hernando, Ana/0000-0002-0676-0188; Johnson,
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NR 95
TC 76
Z9 81
U1 1
U2 35
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0954-6820
EI 1365-2796
J9 J INTERN MED
JI J. Intern. Med.
PD MAR
PY 2020
VL 287
IS 3
BP 252
EP 262
DI 10.1111/joim.12993
PG 11
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA KM7TU
UT WOS:000514343800004
PM 31621967
OA Bronze
DA 2025-06-11
ER

PT J
AU Linecker, M
   Frick, L
   Kron, P
   Limani, P
   Kambakamba, P
   Tschuor, C
   Langiewicz, M
   Kachaylo, E
   Tian, YH
   Schneider, MA
   Ungethüm, U
   Calo, N
   Foti, M
   Dufour, JF
   Graf, R
   Humar, B
   Clavien, PA
AF Linecker, Michael
   Frick, Lukas
   Kron, Philipp
   Limani, Perparim
   Kambakamba, Patryk
   Tschuor, Christoph
   Langiewicz, Magda
   Kachaylo, Ekaterina
   Tian, Yinghua
   Schneider, Marcel A.
   Ungethum, Udo
   Calo, Nicolas
   Foti, Michelangelo
   Dufour, Jean-Francois
   Graf, Rolf
   Humar, Bostjan
   Clavien, Pierre-Alain
TI Exercise Improves Outcomes of Surgery on Fatty Liver in Mice A Novel
   Effect Mediated by the AMPK Pathway
SO ANNALS OF SURGERY
LA English
DT Article
DE AMPK activation; ischemia-reperfusion injury; liver resection;
   nonalcoholic fatty liver disease; physical activity; treadmill running
ID ACTIVATED PROTEIN-KINASE; ISCHEMIA-REPERFUSION INJURY;
   HEPATOCELLULAR-CARCINOMA; MYOCARDIAL-INFARCTION; CALORIC RESTRICTION;
   DIABETES-MELLITUS; HEPATIC STEATOSIS; DISEASE; HEPATECTOMY; ACADESINE
AB Objective: To investigate whether exercise improves outcomes of surgery on fatty liver, and whether pharmacological approaches can substitute exercising programs. Summary of Background Data: Steatosis is the hepatic manifestation of the metabolic syndrome, and decreases the liver's ability to handle inflammatory stress or to regenerate after tissue loss. Exercise activates adenosine monophosphate-activated kinase (AMPK) and mitigates steatosis; however, its impact on ischemia-reperfusion injury and regeneration is unknown. Methods: We used a mouse model of simple, diet-induced steatosis and assessed the impact of exercise on metabolic parameters, ischemia-reperfusion injury and regeneration after hepatectomy. The same parameters were evaluated after treatment of mice with the AMPK activator 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR). Mice on a control diet served as age-matched controls. Results: A 4-week-exercising program reversed steatosis, lowered insulin levels, and improved glucose tolerance. Exercise markedly enhanced the ischemic tolerance and the regenerative capacity of fatty liver. Replacing exercise with AICAR was sufficient to replicate the above benefits. Both exercise and AICAR improved survival after extended hepatectomy in mice challenged with a Western diet, indicating protection from resection-induced liver failure. Conclusions: Exercise efficiently counteracts the metabolic, ischemic, and regenerative deficits of fatty liver. AICAR acts as an exercise mimetic in settings of fatty liver disease, an important finding given the compliance issues associated with exercise. Exercising, or its substitution through AICAR, may provide a feasible strategy to negate the hepatic consequences of energy-rich diet, and has the potential to extend the application of liver surgery if confirmed in humans.
C1 [Linecker, Michael; Frick, Lukas; Kron, Philipp; Limani, Perparim; Kambakamba, Patryk; Tschuor, Christoph; Langiewicz, Magda; Kachaylo, Ekaterina; Tian, Yinghua; Schneider, Marcel A.; Ungethum, Udo; Graf, Rolf; Humar, Bostjan; Clavien, Pierre-Alain] Univ Hosp Zurich, Swiss HPB & Transplant Ctr, Zurich, Switzerland.
   [Calo, Nicolas; Foti, Michelangelo] Univ Geneva, Fac Med, Dept Cellular Physiol & Metab, Geneva, Switzerland.
   [Dufour, Jean-Francois] Univ Hosp Bern, Dept Clin Res, Hepatol Unit, Bern, Switzerland.
C3 University of Zurich; University Zurich Hospital; University of Geneva;
   University of Bern; University Hospital of Bern
RP Clavien, PA (corresponding author), Univ Hosp Zurich, Dept Surg & Transplantat, Ramistr 100, CH-8091 Zurich, Switzerland.
EM clavien@access.uzh.ch
RI Linecker, Michael/W-5965-2019; Dufour, Jean/AAL-9866-2020; Frick,
   Lukas/JCE-2604-2023; Tschuor, Christoph/MSW-4343-2025; Schneider, Marcel
   Andre/AAW-9712-2020
OI Humar, Bostjan/0000-0002-7956-3062; CALO, Nicolas/0000-0002-0897-4091;
   Linecker, MD PhD, Michael/0000-0002-0721-6811; Schneider, Marcel
   Andre/0000-0002-6723-8879; Kron, Philipp/0000-0002-6074-7072; Foti,
   Michelangelo/0000-0001-7199-4135
FU LGID (Liver and Gastrointestinal Disease) Foundation, Zurich,
   Switzerland; Swiss National Science Foundation [CRSII3_141798/1,
   CRSII3_160717/1]; Swiss National Science Foundation (SNF)
   [CRSII3_141798, CRSII3_160717] Funding Source: Swiss National Science
   Foundation (SNF)
FX This study was supported by the LGID (Liver and Gastrointestinal
   Disease) Foundation, Zurich, Switzerland, and through Sinergia Grants
   from the Swiss National Science Foundation (CRSII3_141798/1 and
   CRSII3_160717/1).
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NR 50
TC 10
Z9 12
U1 1
U2 12
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0003-4932
EI 1528-1140
J9 ANN SURG
JI Ann. Surg.
PD FEB
PY 2020
VL 271
IS 2
BP 347
EP 355
DI 10.1097/SLA.0000000000002904
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA NC5ZL
UT WOS:000561296300028
PM 30138163
OA Green Published
DA 2025-06-11
ER

PT J
AU Oszukowska, M
   Korlowska, M
   Kaszuba, A
AF Oszukowska, Magdalena
   Korlowska, Magdalena
   Kaszuba, Andrzej
TI Paraoxonase-1 and other factors related to oxidative stress in psoriasis
SO POSTEPY DERMATOLOGII I ALERGOLOGII
LA English
DT Article
DE psoriasis; paraoxonase-1; alpha-tocopherol; homocysteine; uric acid
ID LIPID-PEROXIDATION; ANTIOXIDANT STATUS; OXIDIZED LDL; URIC-ACID;
   VITAMIN-E; HOMOCYSTEINE; ENZYME; POLYMORPHISM; EXPRESSION; RISK
AB Introduction: Psoriasis is considered as a risk factor for atherosclerosis and contributes to myocardial infarction, ischemic heart disease and brain stroke.
   Aim: To estimate the atherogenic potential of psoriasis by analysing antioxidative and prooxidative factors (paraoxonase-1, alpha-tocopherol, uric acid, homocysteine), compare levels of these parameters between groups of psoriatic patients and healthy individuals as well as to analyse the impact of psoriasis severity and duration on the factors under the study and to define correlation between the marked factors and patients' lifestyles, body mass index (BMI) and abdominal circumference.
   Material and methods: The investigated group consisted of 66 patients with psoriasis vulgaris, while the control group comprised 30 persons. Both groups were comparable as regards their age, sex and BMI as well as abdominal circumference.
   Results: A significantly lower activity of paraoxonase-1 (p < 0.001), level of tocopherol (p < 0.05) and significantly higher concentration of homocysteine (p < 0.01), uric acid (p < 0.05) were found in patients with psoriasis as compared to the reference group. A higher homocysteine level occurs in patients with a negative family history of psoriasis (p < 0.05). In the group of patients with psoriasis and metabolic syndrome, the uric acid level was significantly higher (p < 0.05). Concentration of uric acid correlated negatively with the abdominal circumference value (p < 0.001).
   Conclusions: Psoriasis promotes arteriosclerosis development by decreasing the levels of antiatherogenic and increasing the levels of proatherogenic agents. Adverse changes in psoriatic patients involve activity of paraoxonase-1, levels of alpha-tocopherol, uric acid, homocysteine as compared to healthy individuals selected by their age, BMI and abdominal circumference value.
C1 [Oszukowska, Magdalena; Korlowska, Magdalena; Kaszuba, Andrzej] Med Univ Lodz, Dept Dermatol Pediat & Oncol Dermatol, 1-5 Kniaziewicza St, PL-91347 Lodz, Poland.
C3 Medical University Lodz
RP Kaszuba, A (corresponding author), Med Univ Lodz, Dept Dermatol Pediat & Oncol Dermatol, 1-5 Kniaziewicza St, PL-91347 Lodz, Poland.
EM andrzej.kaszuba@umed.lodz.pl
RI Mężyńska, Magdalena/T-2182-2018
OI Kozlowska, Magdalena/0000-0002-8624-3948
FU Medical University of Lodz [502-03/5-064-01/502-54-171]
FX The study was funded by the Medical University of Lodz, project no.
   502-03/5-064-01/502-54-171.
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NR 31
TC 15
Z9 15
U1 0
U2 8
PU TERMEDIA PUBLISHING HOUSE LTD
PI POZNAN
PA KLEEBERGA ST 2, POZNAN, 61-615, POLAND
SN 1642-395X
J9 POSTEP DERM ALERGOL
JI Postep. Dermatol. Alergol.
PY 2020
VL 37
IS 1
BP 92
EP 96
DI 10.5114/ada.2020.93386
PG 5
WC Allergy; Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Allergy; Dermatology
GA KU3EP
UT WOS:000519592400015
PM 32467691
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Grupper, A
   Ehrenwald, M
   Schwartz, D
   Berliner, S
   Shashar, M
   Baruch, R
   Schwartz, IF
   Rogowski, O
   Zeltser, D
   Shapira, I
   Shenhar-Tsarfaty, S
AF Grupper, Ayelet
   Ehrenwald, Michal
   Schwartz, Doron
   Berliner, Shlomo
   Shashar, Moshe
   Baruch, Roni
   Schwartz, Idit F.
   Rogowski, Ori
   Zeltser, David
   Shapira, Itzhak
   Shenhar-Tsarfaty, Shani
TI Hypertension is associated with increased post-exercise albuminuria,
   which may be attenuated by an active lifestyle
SO JOURNAL OF CLINICAL HYPERTENSION
LA English
DT Article
DE endothelial dysfunction; hypertension; urine albumin excretion; urine
   albumin-to-creatinine ratio
ID EXERCISE-INDUCED ALBUMINURIA; ENDOTHELIAL DYSFUNCTION; RENAL-FUNCTION;
   METABOLIC SYNDROME; PHYSICAL-ACTIVITY; NERVOUS-SYSTEM; MICROALBUMINURIA;
   EXCRETION; DISEASE; PROGRESSION
AB Albuminuria is a known marker for endothelial dysfunction and cardiovascular events, even below the threshold of moderately increased albuminuria (MIA). Post-exercise increased albuminuria may precede the appearance of rest MIA, enabling detection of early injury. Modifying lifestyle for a population at risk for MIA is therefore of interest. Our aim was to evaluate post-exercise albuminuria in hypertensive compared with normotensive individuals and to analyze the effect of an active lifestyle on rest and post-exercise albumin excretion. The study cohort consisted of 3931 adults who participated in a health-screening program. Albuminuria was measured as urine albumin-to-creatinine ratio (ACR). Lifestyle was divided into three groups: non-active, less-active, and active according to regular sport activity, categorized as follows: none, <2.5 and >= 2.5 hours per week. Mean age was 47.7 years, and 31.2% (n = 1228) were diagnosed with hypertension. Both rest and post-exercise ACR were higher in hypertensive compared to normotensive participants. Rest ACR was higher in non-active compared to less-active and active hypertensive participants. Hypertensive participants with an active lifestyle had significantly lower post-exercise and delta ACR compared to less-active and non-active hypertensive participants. Parameters related to delta ACR in hypertensive participants were increased age, BMI, and diabetes, while active lifestyle and fitness (measured as METS achieved by a stress test) were protective. In conclusion, there is an association between hypertension and increased albumin excretion post-exercise, which can be attenuated with an active lifestyle.
C1 [Grupper, Ayelet; Schwartz, Doron; Shashar, Moshe; Baruch, Roni; Schwartz, Idit F.] Tel Aviv Univ, Tel Aviv Sourasky Med Ctr, Nephrol Dept, Tel Aviv, Israel.
   [Grupper, Ayelet; Ehrenwald, Michal; Schwartz, Doron; Berliner, Shlomo; Shashar, Moshe; Baruch, Roni; Schwartz, Idit F.; Rogowski, Ori; Zeltser, David; Shapira, Itzhak; Shenhar-Tsarfaty, Shani] Tel Aviv Univ, Sackler Fac Med, Tel Aviv, Israel.
   [Ehrenwald, Michal; Berliner, Shlomo; Rogowski, Ori; Zeltser, David; Shapira, Itzhak; Shenhar-Tsarfaty, Shani] Tel Aviv Univ, Dept Internal Med C D&E, Tel Aviv Sourasky Med Ctr, Tel Aviv, Israel.
   [Shashar, Moshe] Laniado Hosp, Sanz Med Ctr, Renal Sect, Netanya, Israel.
C3 Tel Aviv University; Sackler Faculty of Medicine; Tel Aviv Sourasky
   Medical Center; Tel Aviv University; Sackler Faculty of Medicine; Tel
   Aviv University; Sackler Faculty of Medicine; Tel Aviv Sourasky Medical
   Center
RP Grupper, A (corresponding author), Tel Aviv Sourasky Med Ctr, 6 Weizman St, IL-6423906 Tel Aviv, Israel.
EM ayeletg@tlvmc.gov.il
RI Zeltser, David/LYO-6304-2024
OI Grupper, Ayelet/0000-0002-5590-9428; shashar, moshe/0000-0002-9744-856X
FU Tel-Aviv Sourasky Medical Center; Israel Hamer, Frida Hamer, and Chaia
   Hamer Foundation; Sackler Faculty of Medicine, Tel-Aviv University
FX This study was supported by an internal research grant, from the
   Tel-Aviv Sourasky Medical Center (to SB and IS), and by a grant from the
   Israel Hamer, Frida Hamer, and Chaia Hamer Foundation, The Sackler
   Faculty of Medicine, Tel-Aviv University (to SST and OR).
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NR 49
TC 6
Z9 6
U1 0
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1524-6175
EI 1751-7176
J9 J CLIN HYPERTENS
JI J. Clin. Hypertens.
PD AUG
PY 2019
VL 21
IS 8
BP 1171
EP 1179
DI 10.1111/jch.13624
EA JUL 2019
PG 9
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA IQ2PR
UT WOS:000474551600001
PM 31282604
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Chen, YN
   Qian, QA
   Yu, JA
AF Chen, Yuning
   Qian, Qian
   Yu, Jian
TI Carbenoxolone ameliorates insulin sensitivity in obese mice induced by
   high fat diet via regulating the IκB-α/NF-κB pathway and NLRP3
   inflammasome
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Article
DE Obesity; Carbenoxolone; I kappa B-alpha/NF-kappa B pathway; NLRP3
   inflammasome; Insulin resistance
ID METABOLIC SYNDROME; ACTIVATION; RESISTANCE; INHIBITION; STRESS;
   IL-1-BETA; RECEPTOR; TISSUE
AB The characteristic feature of obesity and insulin resistance is chronic low-grade inflammation. Nod-Like Receptor Pyrin 3 (NLRP3) inflammasome plays a central role in obesity-induced insulin resistance. However, how does Carbenoxolone (CBX) play its role in ameliorating insulin resistance in peripheral tissues of obese mice induced by high-fat diet (HFD) remains unknown. In our study, we explored the molecular mechanism of CBX in improving insulin resistance in liver and skeletal muscle in mice induced by the HFD. Our results revealed that in the CBX group, a significant decrease in fasting blood glucose, insulin and HOMA-IR score were observed. CBX could attenuate intracellular lipid accumulation and inflammation aggravation in liver and skeletal muscle. Besides, treatment with CBX could significantly reduce expressions of p-I kappa B-alpha, p-NF-kappa B, p-IRS-1, NLRP3 and inflammatory factors, increase expressions of p-PI3K and p-AKT. Therefore, CBX could dramatically improve insulin resistance in liver and skeletal muscle in mice induced by the high-fat diet. In conclusions, we demonstrate that CBX has a significant protective effect on diet-induced obesity in mice. The potential mechanisms include inhibiting I kappa B-alpha/NF-kappa B pathway, restricting the production of NLRP3 inflammasome and other inflammatory factors, reducing the expression of p-IRS-1, increasing the expressions of p-PI3K and p-AKT, thus ameliorating insulin resistance in liver and skeletal muscle of high-fat diet mice. Therefore CBX is an active agent against diet-induced obesity and is given the opportunity for the treatment of obesity related diseases.
C1 [Chen, Yuning; Yu, Jian] Soochow Univ, Affiliated Hosp 3, Dept Geriatr, Changzhou, Jiangsu, Peoples R China.
   [Qian, Qian] Soochow Univ, Affiliated Hosp 3, Dept Gastroenterol, Changzhou, Jiangsu, Peoples R China.
C3 Soochow University - China; Soochow University - China
RP Chen, YN (corresponding author), Soochow Univ, Affiliated Hosp 3, Dept Geriatr, Changzhou, Jiangsu, Peoples R China.
EM czyy85502302@163.com
FU Natural Science Foundation of China [81300687]
FX This study was supported by the Natural Science Foundation of China
   (81300687).
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NR 42
TC 25
Z9 31
U1 1
U2 23
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD JUL
PY 2019
VL 115
AR 108868
DI 10.1016/j.biopha.2019.108868
PG 11
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA IC0QJ
UT WOS:000470664600014
PM 30999127
OA gold
DA 2025-06-11
ER

PT J
AU Robison, LS
   Gannon, OJ
   Salinero, AE
   Zuloaga, KL
AF Robison, Lisa S.
   Gannon, Olivia J.
   Salinero, Abigail E.
   Zuloaga, Kristen L.
TI Contributions of sex to cerebrovascular function and pathology
SO BRAIN RESEARCH
LA English
DT Review
DE Sex differences; Sex hormones; Cerebrovascular disease; Vascular;
   Stroke; Dementia
ID BLOOD-BRAIN-BARRIER; ESTROGEN-RECEPTOR-ALPHA; CEREBRAL-ARTERY OCCLUSION;
   NITRIC-OXIDE SYNTHASE; ISCHEMIA-REPERFUSION INJURY; CYTOKINE-INDUCED
   CYCLOOXYGENASE-2; ANTIOXIDANT ENZYME EXPRESSION; ESTRADIOL-MEDIATED
   PROTECTION; TIGHT JUNCTION DISRUPTION; NON-GENOMIC ACTIONS
AB Sex differences exist in how cerebral blood vessels function under both physiological and pathological conditions, contributing to observed sex differences in risk and outcomes of cerebrovascular diseases (CBVDs), such as vascular contributions to cognitive impairment and dementia (VCID) and stroke. Throughout most of the lifespan, women are protected from CBVDs; however, risk increases following menopause, suggesting sex hormones may play a significant role in this protection. The cerebrovasculature is a target for sex hormones, including estrogens, progestins, and androgens, where they can influence numerous vascular functions and pathologies. While there is a plethora of information on estrogen, the effects of progestins and androgens on the cerebrovasculature are less well-defined. Estrogen decreases cerebral tone and increases cerebral blood flow, while androgens increase tone. Both estrogens and androgens enhance angiogenesis/cerebrovascular remodeling. While both estrogens and androgens attenuate cerebrovascular inflammation, pro-inflammatory effects of androgens under physiological conditions have also been demonstrated. Sex hormones exert additional neuroprotective effects by attenuating oxidative stress and maintaining integrity and function of the blood brain barrier. Most animal studies utilize young, healthy, gonadectomized animals, which do not mimic the clinical conditions of aging individuals likely to get CBVDs. This is also concerning, as sex hormones appear to mediate cerebrovascular function differently based on age and disease state (e.g. metabolic syndrome). Through this review, we hope to inspire others to consider sex as a key biological variable in cerebrovascular research, as greater understanding of sex differences in cerebrovascular function will assist in developing personalized approaches to prevent and treat CBVDs.
C1 [Robison, Lisa S.; Gannon, Olivia J.; Salinero, Abigail E.; Zuloaga, Kristen L.] Albany Med Coll, Dept Neurosci & Expt Therapeut, 47 New Scotland Ave, Albany, NY 12208 USA.
C3 Albany Medical College
RP Zuloaga, KL (corresponding author), Albany Med Coll, 47 New Scotland Ave,MC-136, Albany, NY 12208 USA.
EM robisol@amc.edu; gannono@amc.edu; salinea@amc.edu; zuloagk@amc.edu
OI Robison, Lisa/0000-0002-5110-9183; Zuloaga, Kristen/0000-0002-5395-7362
FU American Heart Association [16SDG27190001]; Albany Medical College
   start-up funds; American Heart Association (AHA) [16SDG27190001] Funding
   Source: American Heart Association (AHA)
FX This work was supported by American Heart Association Scientist
   Development Grant 16SDG27190001 (KLZ) and Albany Medical College
   start-up funds (KLZ).
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NR 326
TC 80
Z9 86
U1 1
U2 31
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0006-8993
EI 1872-6240
J9 BRAIN RES
JI Brain Res.
PD MAY 1
PY 2019
VL 1710
BP 43
EP 60
DI 10.1016/j.brainres.2018.12.030
PG 18
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA HR4PZ
UT WOS:000463129700005
PM 30580011
DA 2025-06-11
ER

PT J
AU Brenner, R
   Kivity, S
   Peker, M
   Reinhorn, D
   Keinan-Boker, L
   Silverman, B
   Liphsitz, I
   Kolitz, T
   Levy, C
   Shlomi, D
   Pillar, G
   Peled, N
AF Brenner, Ronen
   Kivity, Shaye
   Peker, Marina
   Reinhorn, Daniel
   Keinan-Boker, Lital
   Silverman, Barbara
   Liphsitz, Irena
   Kolitz, Tamara
   Levy, Carmit
   Shlomi, Dekel
   Pillar, Giora
   Peled, Nir
TI Increased Risk for Cancer in Young Patients with Severe Obstructive
   Sleep Apnea
SO RESPIRATION
LA English
DT Article
DE OSAS; Cancer; Survival
ID TUMOR-ASSOCIATED MACROPHAGES; HYPOXIA-INDUCIBLE FACTOR; INTERMITTENT
   HYPOXIA; METABOLIC SYNDROME; MOUSE MODEL; CARDIOVASCULAR-DISEASE;
   OXIDATIVE STRESS; BLOOD-PRESSURE; PROGRESSION; MORTALITY
AB Background: Several studies in animal models and human with obstructive sleep apnea syndrome (OSAS) demonstrated an increase in cancer aggressiveness and mortality. However, there is a need for further clinical evidence supporting a correlation between OSAS and cancer incidence. Objectives: To reveal whether OSAS presence and severity is correlated with cancer incidence in a large homogenous patients' cohort. Methods: We analyzed a cohort of over 5,000 concurrently enrolled patients, age >18, with suspected OSAS, from a tertiary medical academic center. Patients underwent whole night polysomnography, the gold standard diagnostic tool for OSAS, and were classified for severity according to the Apnea Hypopnea Index (AHI). Data on cancer incidence were obtained from the Israel National Cancer Registry. A multivariate Cox proportional-hazards analysis, adjusted for age, gender, and BMI, was performed to estimate the hazard-ratio of new cancer incidence. Results: Among 5,243 subjects with a median follow-up of 5.9 years, 265 were diagnosed with cancer. The most prevalent cancers were prostate (14.7%), hematological (12.8%), urothelial (9.4%), colorectal (9%), and breast (8.3%). In subjects who were diagnosed at age below 45 years (n = 1,533), a high AHI (>57/h) was significantly associated with cancer (HR 3.7, CI 1.12-12.45, p = 0.008). Conclusions: Patients younger than 45 with severe OSAS have a significantly higher all-type cancer incidence than the general population. These results should encourage clinicians to detect and diagnose young patients with suspected OSAS and to recommend cancer screening methods in this high-risk population. (C) 2018 S. Karger AG, Basel
C1 [Brenner, Ronen; Kolitz, Tamara] Wolfson Med Ctr, Oncol Inst, Holon, Israel.
   [Kivity, Shaye] Sheba Med Ctr, Dr Pinchas Borenstein Talpiot Med Leadership Prog, Dept Med A, Tel Hashomer, Israel.
   [Kivity, Shaye] Sheba Med Ctr, Dr Pinchas Borenstein Talpiot Med Leadership Prog, Dept Med C, Tel Hashomer, Israel.
   [Peker, Marina; Reinhorn, Daniel] Rabin Med Ctr, Davidoff Canc Ctr, Petah Tiqwa, Israel.
   [Keinan-Boker, Lital; Silverman, Barbara; Liphsitz, Irena] Israel Minist Hlth, Natl Canc Registry, Jerusalem, Israel.
   [Keinan-Boker, Lital] Israel Minist Hlth, Israel Ctr Dis Control, Jerusalem, Israel.
   [Levy, Carmit] Tel Aviv Univ, Sackler Fac Med, Dept Human Genet & Biochem, Tel Aviv, Israel.
   [Shlomi, Dekel] Clalit Hlth Serv, Dan Petah Tiqwa Dist, Israel.
   [Pillar, Giora] Rambam Med Ctr, Haifa, Israel.
   [Brenner, Ronen; Kivity, Shaye] Tel Aviv Univ, Sackler Fac Med, Tel Aviv, Israel.
   [Pillar, Giora] Technion Israel Inst Technol, Rappaport Fac Med, Haifa, Israel.
   [Peled, Nir] Ben Gurion Univ Negev, Beer Sheva, Israel.
   [Peled, Nir] Legacy Heritage Oncol Ctr, Oncol Div, Beer Sheva, Israel.
   [Peled, Nir] Soroka Med Ctr, Dr Larry Norton Inst, Beer Sheva, Israel.
C3 Tel Aviv University; Tel Aviv University; Chaim Sheba Medical Center;
   Chaim Sheba Medical Center; Tel Aviv University; Rabin Medical Center;
   Ministry of Health - Israel; Ministry of Health - Israel; Tel Aviv
   University; Sackler Faculty of Medicine; Clalit Health Services; Rambam
   Health Care Campus; Tel Aviv University; Sackler Faculty of Medicine;
   Technion Israel Institute of Technology; Rappaport Faculty of Medicine;
   Ben-Gurion University of the Negev; Ben-Gurion University of the Negev;
   Soroka Medical Center
RP Peled, N (corresponding author), Ben Gurion Univ Negev, Beer Sheva, Israel.; Peled, N (corresponding author), Legacy Heritage Oncol Ctr, Oncol Div, Beer Sheva, Israel.; Peled, N (corresponding author), Soroka Med Ctr, Dr Larry Norton Inst, Beer Sheva, Israel.
EM peled.nir@gmail.com
RI Shlomi, Dekel/AAX-8270-2021; Peled, Noam/AAV-4407-2020; Pillar,
   Giora/AAF-3015-2020
OI Pillar, Giora/0000-0002-0553-4226; Peled, Nir/0000-0003-3714-4377
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NR 47
TC 56
Z9 58
U1 2
U2 14
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0025-7931
EI 1423-0356
J9 RESPIRATION
JI Respiration
PY 2019
VL 97
IS 1
BP 15
EP 23
DI 10.1159/000486577
PG 9
WC Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Respiratory System
GA HF4CL
UT WOS:000454180700005
PM 30419556
OA Bronze
DA 2025-06-11
ER

PT J
AU Abenavoli, L
   Greco, M
   Milic, N
   Accattato, F
   Foti, D
   Gulletta, E
   Luzza, F
AF Abenavoli, Ludovico
   Greco, Marta
   Milic, Natasa
   Accattato, Francesca
   Foti, Daniela
   Gulletta, Elio
   Luzza, Francesco
TI Effect of Mediterranean Diet and Antioxidant Formulation in
   Non-Alcoholic Fatty Liver Disease: A Randomized Study
SO NUTRIENTS
LA English
DT Article
DE non-alcoholic fatty liver disease; Mediterranean diet; insulin
   resistance; weight; antioxidant
ID E-PHOSPHOLIPID COMPLEX; VITAMIN-E; INSULIN-RESISTANCE;
   LIPID-PEROXIDATION; METABOLIC SYNDROME; STEATOHEPATITIS; INTERVENTION;
   EPIDEMIOLOGY; GLUCOSE; TARGET
AB Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide, characterized by liver fatty acid accumulation and fibrosis, not due to excessive alcohol consumption. Notably, nutritional habits have been reported to be implicated in the onset and severity of the hepatic damage, while the Mediterranean diet has shown beneficial effects on NAFLD. Free radicals and oxidative stress were suggested to be involved in the pathogenesis and progression of NAFLD, and several data highlighted the efficacy of antioxidant supplementation in its treatment. The aim of this study was to compare the effects of the Mediterranean diet, with or without an antioxidant complex supplement, in overweight patients suffering from NAFLD. In this prospective study, fifty Caucasian overweight patients were randomized into three groups (Groups A-C). A personalized moderately hypocaloric Mediterranean diet was prescribed to all patients included in the A and B groups. In addition to the diet, Group B was administered antioxidant supplementation daily and for the period of six months. Group C did not have any type of treatment. The study proved that the Mediterranean diet alone or in association with the antioxidant complex improved anthropometric parameters, lipid profile and reduced hepatic fat accumulation and liver stiffness. However, Group B patients, in which the diet was associated with antioxidant intake, showed not only a significant improvement in insulin sensitivity, but also a more consistent reduction of anthropometric parameters when compared with Group A patients. Taken together, these results support the benefit of antioxidant supplementation in overweight patients with NAFLD.
C1 [Abenavoli, Ludovico; Greco, Marta; Accattato, Francesca; Foti, Daniela; Gulletta, Elio; Luzza, Francesco] Magna Graecia Univ Catanzaro, Dept Hlth Sci, I-88100 Catanzaro, Italy.
   [Milic, Natasa] Univ Novi Sad, Dept Pharm, Novi Sad 21000, Serbia.
C3 Magna Graecia University of Catanzaro; University of Novi Sad
RP Abenavoli, L (corresponding author), Magna Graecia Univ Catanzaro, Dept Hlth Sci, I-88100 Catanzaro, Italy.
EM l.abenavoli@unicz.it; marta.greco@unicz.it; milnat@libero.it;
   francescaaccattato@libero.it; foti@unicz.it; gulletta@unicz.it;
   luzza@unicz.it
RI Foti, Daniela/K-8038-2016; Brunetti, Antonio/K-7756-2016; Abenavoli,
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NR 57
TC 99
Z9 103
U1 2
U2 25
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD AUG
PY 2017
VL 9
IS 8
AR 870
DI 10.3390/nu9080870
PG 13
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA FF1VU
UT WOS:000408688100077
PM 28805669
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Whaley-Connell, A
   Sowers, JR
AF Whaley-Connell, Adam
   Sowers, James R.
TI Obesity and kidney disease: from population to basic science and the
   search for new therapeutic targets
SO KIDNEY INTERNATIONAL
LA English
DT Review
DE chronic kidney disease; mineralocorticoid receptor; obesity;
   tubulointerstitial fibrosis
ID BODY-MASS INDEX; EPITHELIAL-MESENCHYMAL TRANSITION;
   PLASMINOGEN-ACTIVATOR INHIBITOR-1; ANGIOTENSIN-II; INSULIN-RESISTANCE;
   METABOLIC SYNDROME; GENE-EXPRESSION; NITRIC-OXIDE; TGF-BETA;
   DIABETIC-NEPHROPATHY
AB The global burden of kidney disease is increasing strikingly in parallel with increases in obesity and diabetes. Indeed, chronic kidney disease (CKD) and end-stage renal disease (ESRD) coupled with comorbidities such as obesity, diabetes, and hypertension cost the health care system hundreds of billions of dollars in the US alone. The progression to ESRD in patients with obesity and diabetes continues despite widespread use of inhibitors of the reninangiotensin- aldosterone system (RAAS) along with aggressive blood pressure and glycemic control in these high- risk populations. Thereby, it is increasingly important to better understand the underlying mechanisms involved in obesity- related CKD in order to develop new strategies that prevent or interrupt the progression of this costly disease. In this context, a key mechanism that drives development and progression of kidney disease in obesity is endothelial dysfunction and associated tubulointerstitial fibrosis. However, the precise interactive mechanisms in the development of aortic and kidney endothelial dysfunction and tubulointerstitial fibrosis remain unclear. Further, strategies specifically targeting kidney fibrosis have yielded inconclusive benefits in human studies. While clinical data support the benefits derived from inhibition of the RAAS, there is a tremendous amount of residual risk for the progression of kidney disease in individuals with obesity and diabetes. There is promising experimental data to suggest that exercise, targeting inflammation and oxidative stress, lowering uric acid, and targeting the mineralocorticoid receptor signaling and/or sodium channel inhibition could improve tubulointerstitial fibrosis and mitigate progression of kidney disease in persons with obesity and diabetes.
C1 [Whaley-Connell, Adam; Sowers, James R.] Harry S Truman Mem Vet Hosp, 800 Hosp Dr, Columbia, MO 65201 USA.
   [Whaley-Connell, Adam; Sowers, James R.] Univ Missouri Columbia, Sch Med, Diabet & Cardiovasc Ctr, Columbia, MO USA.
   [Whaley-Connell, Adam] Univ Missouri Columbia, Sch Med, Div Nephrol & Hypertens, Columbia, MO USA.
   [Whaley-Connell, Adam; Sowers, James R.] Univ Missouri Columbia, Sch Med, Div Endocrinol & Metab, Columbia, MO USA.
   [Whaley-Connell, Adam; Sowers, James R.] Univ Missouri Columbia, Sch Med, Dept Med, Columbia, MO USA.
   [Sowers, James R.] Univ Missouri Columbia, Sch Med, Dept Med Pharmacol & Physiol, Columbia, MO USA.
C3 US Department of Veterans Affairs; Veterans Health Administration (VHA);
   Harry S. Truman Memorial Veterans' Hospital; University of Missouri
   System; University of Missouri Columbia; University of Missouri System;
   University of Missouri Columbia; University of Missouri System;
   University of Missouri Columbia; University of Missouri System;
   University of Missouri Columbia; University of Missouri System;
   University of Missouri Columbia
RP Whaley-Connell, A (corresponding author), Harry S Truman Mem Vet Hosp, 800 Hosp Dr, Columbia, MO 65201 USA.
EM adam.whaley-connell@va.gov
FU Department of Veterans Affairs through facility resources; National
   Institutes of Health [RO1 HL73101-10A, RO1 HL 107910-01]; Veterans
   Affairs Merit System [0018]
FX The authors thank Brenda Hunter (Department of Medicine, Diabetes and
   Cardiovascular Center, University of Missouri) for her editorial
   assistance. This work was supported through the Department of Veterans
   Affairs through facility resources, and JRS has received funding from
   the National Institutes of Health (RO1 HL73101-10A and RO1 HL 107910-01)
   and the Veterans Affairs Merit System (0018).
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NR 135
TC 102
Z9 107
U1 0
U2 13
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0085-2538
EI 1523-1755
J9 KIDNEY INT
JI Kidney Int.
PD AUG
PY 2017
VL 92
IS 2
DI 10.1016/j.kint.2016.12.034
PG 11
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA FA1KI
UT WOS:000405197800011
PM 28341271
OA Bronze
DA 2025-06-11
ER

PT J
AU Kim, Y
   Keogh, JB
   Clifton, PM
AF Kim, Yoona
   Keogh, Jennifer B.
   Clifton, Peter M.
TI Effects of Two Different Dietary Patterns on Inflammatory Markers,
   Advanced Glycation End Products and Lipids in Subjects without Type 2
   Diabetes: A Randomised Crossover Study
SO NUTRIENTS
LA English
DT Article
DE dietary pattern; plasminogen activator inhibitor type 1; advanced
   glycation products; insulin sensitivity
ID PLASMINOGEN-ACTIVATOR INHIBITOR-1; GLYCEMIC-INDEX DIET; C-REACTIVE
   PROTEIN; INSULIN-RESISTANCE ATHEROSCLEROSIS; RED MEAT INTAKE;
   CARDIOVASCULAR-DISEASE; OXIDATIVE STRESS; VEGETABLE INTAKE; CONSUMPTION;
   SENSITIVITY
AB Epidemiological studies suggest that consumption of red and processed meat and refined grains are associated with type 2 diabetes and metabolic syndrome and increased inflammatory and fibrinolytic markers. We hypothesised that a diet high in red and processed meat and refined grains (HMD) would increase inflammatory markers and advanced glycation end products (AGEs) compared with a diet high in dairy, whole grains, nuts and legumes (HWD). We performed a randomised crossover study of two four-week interventions in 51 participants without type 2 diabetes (15 men and 36 women aged 35.1 +/- 15.6 years; body mass index: 27.7 +/- 6.9 kg/m(2)). No baseline measurements were performed. Plasma fluorescent AGEs, carboxymethyllysine, glucose, insulin, lipids, hs-CRP, interleukin 6 (IL-6) and plasminogen activator inhibitor-1 (PAI-1) were analysed after four weeks on each diet. IL-6, hs-CRP, AGEs and carboxymethyllysine were not different between diets but PAI-1 was higher after the HMD than after HWD ((median and interquartile range) 158, 81 vs. 121, 53 ng/mL p < 0.001). PAI-1 on the HWD diet was inversely correlated with whole grains intake (p = 0.007). PAI-1 was inversely correlated with insulin sensitivity index (r = 0.45; p = 0.001) and positively correlated with serum total cholesterol (r = 0.35; p = 0.012) and serum triglyceride (r = 0.32; p = 0.021) on HMD. This trial was registered with the Australian New Zealand Clinical Trials Registry (ACTRN12614000519651).
C1 [Kim, Yoona; Keogh, Jennifer B.; Clifton, Peter M.] Univ South Australia, Sch Pharm & Med Sci, Adelaide, SA 5001, Australia.
C3 University of South Australia
RP Clifton, PM (corresponding author), Univ South Australia, Sch Pharm & Med Sci, Adelaide, SA 5001, Australia.
EM yoona.kim@mymail.unisa.edu.au; Jennifer.Keogh@unisa.edu.au;
   peter.clifton@unisa.edu.au
RI Kim, Yoona/L-3829-2019; Keogh, Jennifer/B-6922-2011; Clifton,
   Peter/F-4446-2013
OI Keogh, Jennifer/0000-0002-4788-3870; Clifton, Peter/0000-0002-6411-626X
FU Australian Government; National Health and Medical Research Council
FX Yoona Kim is supported by an Australian Government Research Training
   Program Scholarship. Peter M. Clifton is supported by a National Health
   and Medical Research Council Principal Research Fellowship.
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NR 54
TC 25
Z9 26
U1 1
U2 13
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 2072-6643
J9 NUTRIENTS
JI Nutrients
PD APR
PY 2017
VL 9
IS 4
AR 336
DI 10.3390/nu9040336
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA EU9JI
UT WOS:000401355600021
PM 28353655
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Guarini, G
   Kiyooka, T
   Ohanyan, V
   Pung, YF
   Marzilli, M
   Chen, YR
   Chen, CL
   Kang, PT
   Hardwick, JP
   Kolz, CL
   Yin, LY
   Wilson, GL
   Shokolenko, I
   Dobson, JG
   Fenton, R
   Chilian, WM
AF Guarini, Giacinta
   Kiyooka, Takahiko
   Ohanyan, Vahagn
   Pung, Yuh Fen
   Marzilli, Mario
   Chen, Yeong Renn
   Chen, Chwen Lih
   Kang, Patrick T.
   Hardwick, James P.
   Kolz, Christopher L.
   Yin, Liya
   Wilson, Glenn L.
   Shokolenko, Inna
   Dobson, James G., Jr.
   Fenton, Richard
   Chilian, William M.
TI Impaired coronary metabolic dilation in the metabolic syndrome is linked
   to mitochondrial dysfunction and mitochondrial DNA damage
SO BASIC RESEARCH IN CARDIOLOGY
LA English
DT Article
DE Coronary microcirculation; Obesity; Diabetes; Coronary circulation;
   Mitochondria
ID MEDIATES S-GLUTATHIONYLATION; OXIDATIVE STRESS; COLLATERAL GROWTH;
   ZUCKER OBESE; ADENOSINE; CHAIN; RATS; ATP; ECHOCARDIOGRAPHY;
   QUANTIFICATION
AB Mitochondrial dysfunction in obesity and diabetes can be caused by excessive production of free radicals, which can damage mitochondrial DNA. Because mitochondrial DNA plays a key role in the production of ATP necessary for cardiac work, we hypothesized that mitochondrial dysfunction, induced by mitochondrial DNA damage, uncouples coronary blood flow from cardiac work. Myocardial blood flow (contrast echocardiography) was measured in Zucker lean (ZLN) and obese fatty (ZOF) rats during increased cardiac metabolism (product of heart rate and arterial pressure, i.v. norepinephrine). In ZLN increased metabolism augmented coronary blood flow, but in ZOF metabolic hyperemia was attenuated. Mitochondrial respiration was impaired and ROS production was greater in ZOF than ZLN. These were associated with mitochondrial DNA (mtDNA) damage in ZOF. To determine if coronary metabolic dilation, the hyperemic response induced by heightened cardiac metabolism, is linked to mitochondrial function we introduced recombinant proteins (intravenously or intraperitoneally) in ZLN and ZOF to fragment or repair mtDNA, respectively. Repair of mtDNA damage restored mitochondrial function and metabolic dilation, and reduced ROS production in ZOF; whereas induction of mtDNA damage in ZLN reduced mitochondrial function, increased ROS production, and attenuated metabolic dilation. Adequate metabolic dilation was also associated with the extracellular release of ADP, ATP, and H2O2 by cardiac myocytes; whereas myocytes from rats with impaired dilation released only H2O2. In conclusion, our results suggest that mitochondrial function plays a seminal role in connecting myocardial blood flow to metabolism, and integrity of mtDNA is central to this process.
C1 [Guarini, Giacinta; Marzilli, Mario] Univ Pisa, Cardiothorac & Vasc Dept, Pisa, Italy.
   [Kiyooka, Takahiko] Tokai Univ, Div Cardiol, Oiso Hosp, Oiso, Japan.
   [Guarini, Giacinta; Ohanyan, Vahagn; Pung, Yuh Fen; Chen, Yeong Renn; Chen, Chwen Lih; Kang, Patrick T.; Hardwick, James P.; Kolz, Christopher L.; Yin, Liya; Chilian, William M.] Northeast Ohio Med Univ, Dept Integrat Med Sci, 4209 State Route 44, Rootstown, OH 44272 USA.
   [Pung, Yuh Fen] Univ Nottingham, Dept Biomed Sci, Semenyih, Malaysia.
   [Wilson, Glenn L.] Univ S Alabama, Dept Cell Biol & Neurosci, Mobile, AL 36688 USA.
   [Shokolenko, Inna] Univ S Alabama, Dept Biomed Sci, Mobile, AL 36688 USA.
   [Dobson, James G., Jr.; Fenton, Richard] Univ Massachusetts, Dept Microbiol & Physiol Syst, Boston, MA 02125 USA.
C3 University of Pisa; Tokai University; University System of Ohio;
   Northeast Ohio Medical University (NEOMED); University of Nottingham
   Malaysia; University of South Alabama; University of South Alabama;
   University of Massachusetts System; University of Massachusetts Boston
RP Chilian, WM (corresponding author), Northeast Ohio Med Univ, Dept Integrat Med Sci, 4209 State Route 44, Rootstown, OH 44272 USA.
EM wchilian@neomed.edu
RI Guarini, Giacinta/J-7542-2016; Pung, Yuh Fen/E-8959-2016
OI Guarini, Giacinta/0000-0001-6451-6995; Kang,
   Patrick/0000-0002-1806-8367; Pung, Yuh Fen/0000-0001-6195-3970
FU Fibus Family Foundation [HL032788, HL083366, HL115114]; AHA
   [POST4360030, POST2290021];  [R15HL115540];  [HL103227];  [DK095895]; 
   [AHA14BGIA18770028];  [HL083237];  [ES03456]
FX The authors wish to acknowledge the following grant support: HL032788,
   HL083366, HL115114, Fibus Family Foundation (WMC); R15HL115540,
   HL103227, DK095895, AHA14BGIA18770028 (LY); AHA POST4360030 (VO);
   HL083237 (Y-RC); AHA POST2290021 (YFP) and ES03456 (GLW).
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NR 36
TC 26
Z9 28
U1 0
U2 14
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0300-8428
EI 1435-1803
J9 BASIC RES CARDIOL
JI Basic Res. Cardiol.
PD MAR
PY 2016
VL 111
IS 3
AR 29
DI 10.1007/s00395-016-0547-4
PG 13
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA DQ1DY
UT WOS:000378942800001
PM 27040114
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Weikel, KA
   Cacicedo, JM
   Ruderman, NB
   Ido, Y
AF Weikel, Karen A.
   Cacicedo, Jose M.
   Ruderman, Neil B.
   Ido, Yasuo
TI Glucose and palmitate uncouple AMPK from autophagy in human aortic
   endothelial cells
SO AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
LA English
DT Article
DE endothelium; autophagy; palmitate; glucose; AMPK
ID ACTIVATED PROTEIN-KINASE; FREE FATTY-ACID; ENDOPLASMIC-RETICULUM STRESS;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; INDUCED APOPTOSIS; SIRT1;
   DYSFUNCTION; PHOSPHORYLATION; INHIBITION
AB Dysregulated autophagy and decreased AMP-activated protein kinase (AMPK) activity are each associated with atherogenesis. Atherogenesis is preceded by high circulating concentrations of glucose and fatty acids, yet the mechanism by which these nutrients regulate autophagy in human aortic endothelial cells (HAECs) is not known. Furthermore, whereas AMPK is recognized as an activator of autophagy in cells with few nutrients, its effects on autophagy in nutrient-rich HAECs has not been investigated. We maintained and passaged primary HAECs in media containing 25 mM glucose and incubated them subsequently with 0.4 mM palmitate. These conditions impaired basal autophagy and rendered HAECs more susceptible to apoptosis and adhesion of monocytes, outcomes attenuated by the autophagy activator rapamycin. Glucose and palmitate diminished AMPK activity and phosphorylation of the uncoordinated-51-like kinase 1 (ULK1) at Ser555, an autophagy-activating site targeted by AMPK. 5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR)-mediated activation of AMPK phosphorylated acetyl-CoA carboxylase, but treatment with AICAR or other AMPK activators (A769662, phenformin) did not restore ULK1 phosphorylation or autophagosome formation. To determine whether palmitate-induced ceramide accumulation contributed to this finding, we overexpressed a ceramide-metabolizing enzyme, acid ceramidase. The increase in acid ceramidase expression ameliorated the effects of excess nutrients on ULK1 phosphorylation, without altering the effects of the AMPK activators. Thus, unlike low nutrient conditions, AMPK becomes uncoupled from autophagy in HAECs in a nutrient-rich environment, such as that found in patients with increased cardiovascular risk. These findings suggest that combinations of AMPK-independent and AMPK-dependent therapies may be more effective alternatives than either therapy alone for treating nutrient-induced cellular dysfunction.
C1 [Weikel, Karen A.] Boston Univ, Sch Med, Dept Med, Boston, MA 02118 USA.
   [Weikel, Karen A.] Boston Med Ctr, Boston, MA 02118 USA.
C3 Boston University; Boston Medical Center
RP Weikel, KA (corresponding author), Boston Univ, Sch Med, Dept Med, 650 Albany St,Rm 820, Boston, MA 02118 USA.
EM karen.weikel@bmc.org
OI /0000-0001-8417-9754; Weikel, Karen/0000-0003-0317-7891
FU National Heart, Lung, and Blood Institute [PO1 HL-068758]; National
   Institute of Diabetes and Digestive and Kidney Diseases Grant from
   National Institutes of Health [T32 DK-007201]
FX Research support was provided by National Heart, Lung, and Blood
   Institute Grant PO1 HL-068758 and National Institute of Diabetes and
   Digestive and Kidney Diseases Grant T32 DK-007201 from National
   Institutes of Health (to N. B. Ruderman).
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NR 96
TC 45
Z9 49
U1 0
U2 20
PU AMER PHYSIOLOGICAL SOC
PI Rockville
PA 6120 Executive Blvd, Suite 600, Rockville, MD, UNITED STATES
SN 0363-6143
EI 1522-1563
J9 AM J PHYSIOL-CELL PH
JI Am. J. Physiol.-Cell Physiol.
PD FEB 1
PY 2015
VL 308
IS 3
BP C249
EP C263
DI 10.1152/ajpcell.00265.2014
PG 15
WC Cell Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Physiology
GA CB0HR
UT WOS:000349307100008
PM 25354528
OA Green Published
DA 2025-06-11
ER

PT J
AU Huang, HY
   Korivi, M
   Yang, HT
   Huang, CC
   Chaing, YY
   Tsai, YC
AF Huang, Hui-Yu
   Korivi, Mallikarjuna
   Yang, Hui-Ting
   Huang, Chi-Chang
   Chaing, Ying-Ying
   Tsai, Ying-Chieh
TI Effect of Pleurotus tuber-regium Polysaccharides
   Supplementation on the Progression of Diabetes Complications in
   Obese-Diabetic Rats
SO CHINESE JOURNAL OF PHYSIOLOGY
LA English
DT Article
DE dyslipidemia; fatty acid composition; hyperglycemia; mushroom; obesity
ID HIGH-FAT DIET; OXIDATIVE STRESS; FRUITING BODIES; HYPERCHOLESTEROLEMIC
   RATS; GLUCOSE-INTOLERANCE; TREMELLA-FUCIFORMIS; METABOLIC SYNDROME;
   SUBMERGED CULTURE; EDIBLE MUSHROOMS; LIPID-METABOLISM
AB In this study, the effect of mushroom extracellular polysaccharides on fatty acid composition and liver peroxisome proliferator-activated receptor-alpha (PPAR-alpha) expression in obese-diabetic rats was investigated, and distinguished the association among anti-obesity, hypoglycemic and hypolipidemic properties. Extracellular polysaccharides from three different strains of Pleurotus tuber-regium were extracted and labeled as HP (high-percentage), MP (medium-percentage) and LP (low-percentage). Obese-diabetes (OD) was induced by chronic high-fat diet plus streptozotocin (STZ) injections. Simultaneously to the diet, polysaccharides were orally administered to OD groups (20 mg/kg body weight/8-week), and categorized into OD+HP, OD+MP and OD+LP groups (n = 10/group), respectively. High-fat diet plus STZ-induced hyperglycemia was prominently attenuated by polysaccharides. Increased fatty acid component n-6/n-3 ratio in liver and plasma of obese-diabetic rats was attenuated, while, reduced MUFA/PUFA and MUFA/SFA ratios were restored (P < 0.01) with polysaccharides treatment. Furthermore, elevated serum total cholesterol, triglycerides and low-density lipoprotein (LDL) concentrations were controlled, and parallel restoration of decreased high-density lipoprotein (HDL) levels were found with polysaccharides supplementation. This hypolipidemic property might be associated with up-regulated liver PPAR-alpha mRNA expression and protein levels (P < 0.01). These findings concluded that stable fatty acid components and activated PPAR-alpha by polysaccharides may contribute to its hypoglycemic and hypolipidemic properties. Therefore, P. tuber-regium could be considered as nutritional supplement to treat diabetic complications.
C1 [Huang, Hui-Yu] Shih Chien Univ, Dept Food Sci Nutr & Nutraceut Biotechnol, Taipei 10462, Taiwan.
   [Korivi, Mallikarjuna] Chang Gung Univ, Coll Med, Dept Occupat Therapy, Taoyuan 33301, Taiwan.
   [Yang, Hui-Ting] China Med Univ, Dept Nutr, Taichung 40402, Taiwan.
   [Huang, Chi-Chang] Natl Taiwan Sport Univ, Grad Inst Sports Sci, Taoyuan 33301, Taiwan.
   [Chaing, Ying-Ying] Hung Kuang Univ, Dept Biotechnol, Taichung 43302, Taiwan.
   [Tsai, Ying-Chieh] Natl Yang Ming Univ, Inst Biochem & Mol Biol, Taipei 11221, Taiwan.
C3 Shih Chien University; Chang Gung University; China Medical University
   Taiwan; National Taiwan Sport University; Hungkuang University; National
   Yang Ming Chiao Tung University
RP Huang, HY (corresponding author), Shih Chien Univ, Dept Food Sci Nutr & Nutraceut Biotechnol, Taipei 10462, Taiwan.
EM maggieh323@hotmail.com
RI Huang, Chi-Chang/A-3280-2013; Korivi, Mallikarjuna/C-7952-2012
OI Korivi, Mallikarjuna/0000-0002-4038-1368; Huang,
   Chi-Chang/0000-0003-1446-6787
FU National Science Council of Taiwan, ROC [NSC99-2324-13-010-001]
FX This study was supported by the National Science Council of Taiwan, ROC
   (NSC99-2324-13-010-001).
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NR 43
TC 41
Z9 44
U1 0
U2 52
PU CHINESE PHYSIOLOGICAL SOC
PI TAIPEI
PA NATL YANG-MING UNIV, TAIPEI, TAIWAN
SN 0304-4920
J9 CHINESE J PHYSIOL
JI Chin. J. Physiol.
PD AUG 31
PY 2014
VL 57
IS 4
BP 198
EP 208
DI 10.4077/CJP.2014.BAC245
PG 11
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA AO4WN
UT WOS:000341342200004
PM 25246061
DA 2025-06-11
ER

PT J
AU Hong, SP
   Noh, TS
   Moon, SH
   Cho, YS
   Lee, EJ
   Choi, JY
   Kim, BT
   Lee, KH
AF Hong, Sun-pyo
   Noh, Tae Soo
   Moon, Seung-Hwan
   Cho, Young Seok
   Lee, Eun Jeong
   Choi, Joon Young
   Kim, Byung-Tae
   Lee, Kyung-Han
TI Hepatic Glucose Uptake Is Increased in Association with Elevated Serum
   γ-Glutamyl Transpeptidase and Triglyceride
SO DIGESTIVE DISEASES AND SCIENCES
LA English
DT Article
DE Fatty liver disease; Glucose; Triglyceride; gamma-Glutamyl transferase
ID FATTY LIVER-DISEASE; METABOLIC SYNDROME; NONALCOHOLIC STEATOHEPATITIS;
   OXIDATIVE STRESS; FDG-PET/CT; STEATOSIS; HISTORY; OBESITY; COHORT
AB Background Subjects with fatty liver disease (FLD) can show increased hepatic 2-deoxy-2-(F-18)fluoro-d-glucose (FDG) uptake, but the role of hepatic inflammation has not been explored.
   We investigated whether hepatic inflammatory response, as implicated by elevated serum markers, is associated with increased liver FDG uptake in FLD.
   Liver sonography and FDG positron emission tomography was performed in 331 asymptomatic men with nonalcoholic FLD (NAFLD), 122 with alcoholic FLD (AFLD), and 349 controls. Mean standard uptake value (SUV) of liver FDG uptake was compared to cardiac risk factors and serum markers of liver injury.
   Hepatic FDG mean SUV was increased in NAFLD (2.40 +/- A 0.25) and AFLD groups (2.44 +/- A 0.25) compared to controls (2.28 +/- A 0.26; both P < 0.001). Both FLD groups also had higher serum gamma-glutamylranspeptidase (GGT), triglyceride (TG), hepatic transaminases, and LDL. High GGT and TG levels were independent determinants of increased FDG uptake for both FLD groups. Hepatic mean SUV significantly increased with high compared to low GGT for NAFLD (2.48 +/- A 0.28 vs. 2.37 +/- A 0.24), AFLD (2.51 +/- A 0.27 vs. 2.39 +/- A 0.23), and control groups (2.39 +/- A 0.22 vs. 2.26 +/- A 0.26). High TG increased hepatic mean SUV in AFLD and control groups. Furthermore, serum GGT and TG levels significantly correlated to hepatic mean SUV in all three groups.
   Hepatic FDG uptake is closely associated with elevated TG and GGT regardless of the presence of FLD. Thus, inflammation response may play a major role in increased hepatic glucose uptake.
C1 [Hong, Sun-pyo; Noh, Tae Soo; Moon, Seung-Hwan; Cho, Young Seok; Lee, Eun Jeong; Choi, Joon Young; Kim, Byung-Tae; Lee, Kyung-Han] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Nucl Med, Seoul, South Korea.
C3 Sungkyunkwan University (SKKU); Samsung Medical Center
RP Lee, KH (corresponding author), Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Nucl Med, 81 Irwon Ro, Seoul, South Korea.
EM khnm.lee@samsung.com
RI Lee, Eun-Hye/KDN-5679-2024; LEE, KYUNG-HAN/HPD-9299-2023; Choi,
   Joon/D-6140-2017
FU Samsung Biomedical Research Institute [C-A9-225-3]
FX This work was supported by the Samsung Biomedical Research Institute
   Grant No. C-A9-225-3.
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NR 27
TC 11
Z9 12
U1 0
U2 12
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0163-2116
EI 1573-2568
J9 DIGEST DIS SCI
JI Dig. Dis. Sci.
PD MAR
PY 2014
VL 59
IS 3
BP 607
EP 613
DI 10.1007/s10620-013-2957-6
PG 7
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA AB7GK
UT WOS:000331957400016
PM 24326630
DA 2025-06-11
ER

PT J
AU Colón-Ramos, U
   Pérez-Cardona, CM
   Monge-Rojas, R
AF Colon-Ramos, Uriyoan
   Perez-Cardona, Cynthia M.
   Monge-Rojas, Rafael
TI Socio-demographic, behavioral, and health correlates of nutrition
   transition dietary indicators in San Juan, Puerto Rico
SO REVISTA PANAMERICANA DE SALUD PUBLICA-PAN AMERICAN JOURNAL OF PUBLIC
   HEALTH
LA English
DT Article
DE Diet; socioeconomic factors; health transition; nutrition; public
   health; Caribbean region; Latin America; Puerto Rico
ID PERCEIVED ACADEMIC STRESS; FAST-FOOD RESTAURANTS; FRIED FOODS; METABOLIC
   SYNDROME; COLLEGE-STUDENTS; RISK; PATTERNS; DISEASE; OBESITY; ADULTS
AB Objective. To identify socio-demographic, behavioral, and health-related correlates of food preferences in Puerto Rico that will help determine Caribbean-region populations vulnerable to nutrition transition.
   Methods. Data from a cross-sectional study of a representative sample of 858 adults residing in the San Juan Metropolitan Area of Puerto Rico were analyzed. Multivariable ordinal logistic regressions were used to model the frequency of consumption of 1) fruits and vegetables, 2) tubers/starchy root vegetables, 3) fried foods, and 4) Western-style fast foods as a function of socio-demographic, behavioral, and health-related characteristics.
   Results. Higher frequency of consumption of fruits and vegetables was associated with being physically active and older and having a medium to high level of education, whereas intake of tubers was associated with being older, having a low income, not using government insurance, and having elevated levels of triglycerides. Frequency of consumption of fast food was associated with younger age, higher income, 12-15 years of formal education, and a higher body mass index (BMI), whereas frequency of consumption of fried food was associated with being younger and male, not being a smoker, and having elevated levels of fasting blood glucose.
   Conclusions. The results indicate a nutrition transition in Puerto Rico with health consequences for the Caribbean region. The characteristics of this nutrition transition seem to be determined by income, education, and age, but may also be dictated by access to various food groups. These results set the stage for needed investigation of environmental and individual-level factors that could shape patterns in food consumption.
C1 [Colon-Ramos, Uriyoan] George Washington Univ, Dept Global Hlth, Washington, DC 20052 USA.
   [Perez-Cardona, Cynthia M.] Univ Puerto Rico, Grad Sch Publ Hlth, Dept Biostat & Epidemiol, San Juan, PR 00936 USA.
   [Monge-Rojas, Rafael] Minist Hlth, Costa Rican Inst Res & Educ Nutr & Hlth INCIENSA, Tres Rios, Costa Rica.
C3 George Washington University; University of Puerto Rico; University of
   Puerto Rico Medical Sciences Campus
RP Colón-Ramos, U (corresponding author), George Washington Univ, Dept Global Hlth, Washington, DC 20052 USA.
EM uriyoan@gwu.edu
RI ColonRamos, Uriyoan/MSZ-9190-2025
OI Colon-Ramos, Uriyoan/0000-0002-0870-9722
FU NCRR NIH HHS [U54 RR026139] Funding Source: Medline; NIMHD NIH HHS [U54
   MD007587, 8U54MD 007587-03] Funding Source: Medline
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NR 37
TC 20
Z9 23
U1 0
U2 11
PU PAN AMER HEALTH ORGANIZATION
PI WASHINGTON
PA 525 23RD ST NW, WASHINGTON, DC 20037 USA
SN 1020-4989
J9 REV PANAM SALUD PUBL
JI Rev. Panam. Salud Publica
PD NOV
PY 2013
VL 34
IS 5
BP 330
EP 335
PG 6
WC Public, Environmental & Occupational Health
WE Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA AB8JP
UT WOS:000332036500005
PM 24553760
DA 2025-06-11
ER

PT J
AU Pallarès, V
   Cedó, L
   Castell-Auví, A
   Pinent, M
   Ardévol, A
   Arola, L
   Blay, M
AF Pallares, Victor
   Cedo, Lidia
   Castell-Auvi, Anna
   Pinent, Montserrat
   Ardevol, Anna
   Arola, Lluis
   Blay, Mayte
TI Effects of grape seed procyanidin extract over low-grade chronic
   inflammation of obese Zucker fa/fa rats
SO FOOD RESEARCH INTERNATIONAL
LA English
DT Article
DE Genetically-induced obesity; Low-chronic inflammation; Procyanidins;
   Zucker obese rats; Adipose tissue; Grape seed extract
ID CONJUGATED LINOLEIC-ACID; HIGH-FAT DIET; ADIPOSE-TISSUE;
   GENE-EXPRESSION; INSULIN-RESISTANCE; METABOLIC SYNDROME; OXIDATIVE
   STRESS; LIPOPOLYSACCHARIDE; APOPTOSIS; CYTOKINES
AB Obesity is associated with chronic inflammation and is related to the accumulation and release of several cytokines from adipose tissue. It has been reported that a grape seed extract (GSPE) containing large amounts of procyanidins, phenolic compounds widely distributed in food, has anti-inflammatory effects in vivo against chronic inflammation related to obesity induced by the diet. In this study, several Zucker fa/fa rats were used as the obese control group (n = 10) and received vehicle treatments, whereas other Zucker fa/fa rats (n = 10) were treated with a moderate dose of 35 mg/kg (*) day of GSPE for a period of 10 weeks. Importantly, GSPE treatment significantly decreased the average level of C-reactive protein (CRP) at 5 weeks of treatment. However, at the end of the experiment (10 weeks of treatment), GSPE could not decrease any of the pro-inflammatory markers tested such as MCP-1, TNF-alpha or CRP. On the contrary, GSPE showed anti-inflammatory effects on mesenteric adipose tissue, as GSPE treatment down-regulated the expression of iNos and Il-6 and up-regulated the expression of Adiponectin in the adipocytes. In conclusion, a moderate dose of GSPE exerts an anti-inflammatory effect in genetically obese rats, modulating the expression of several genes in the adipose tissue and being the adipocyte a target cell of procyanidins. However, this dose could not counteract the pro-inflammatory state at systemic level. (C) 2013 Elsevier Ltd. All rights reserved.
C1 [Pallares, Victor; Cedo, Lidia; Castell-Auvi, Anna; Pinent, Montserrat; Ardevol, Anna; Arola, Lluis; Blay, Mayte] Univ Rovira & Virgili, Dept Bioquim & Biotecnol, E-43007 Tarragona, Spain.
C3 Universitat Rovira i Virgili
RP Blay, M (corresponding author), Univ Rovira & Virgili, Dept Bioquim & Biotecnol, Marcel Li Domingo S-N, E-43007 Tarragona, Spain.
EM victor.pallares@urv.cat; lidia.cedo@urv.cat; anna.castell@urv.cat;
   montserrat.pinent@urv.cat; anna.ardevol@urv.cat; lluis.arola@urv.cat;
   mteresa.blay@urv.cat
RI Ardévol, Anna/AAO-6194-2021; Arola, Lluis/C-6074-2011; Blay, M.
   Teresa/B-1680-2009; Pinent, Montserrat/C-7109-2011; Cedo Gine,
   Lidia/ABG-1998-2020
OI Arola, Lluis/0000-0003-2767-1974; Blay, M. Teresa/0000-0002-6256-9847;
   Ardevol, Anna/0000-0003-0156-7538; Pallares, Victor/0000-0002-9851-0345;
   Pinent, Montserrat/0000-0003-3550-5378; Cedo Gine,
   Lidia/0000-0003-4354-3411
FU MEYC (Ministerio de Educacion y Ciencia) from Spain [AGL2008-00387];
   Rovira i Virgili University; Spanish Ministry of Science and Innovation
   (MICINN); Generalitat de Catalunya
FX This work was entirely performed at the Universitat Rovira i Virgili and
   was supported by grant from the MEYC (Ministerio de Educacion y Ciencia)
   from Spain (no. AGL2008-00387). V. P. received a grant from the Rovira i
   Virgili University for PhD students, A. C-A. received an FPU fellowship
   from the Spanish Ministry of Science and Innovation (MICINN), and L C.
   received a predoctoral fellowship from the Generalitat de Catalunya.
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NR 32
TC 16
Z9 18
U1 1
U2 36
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0963-9969
J9 FOOD RES INT
JI Food Res. Int.
PD AUG
PY 2013
VL 53
IS 1
BP 319
EP 324
DI 10.1016/j.foodres.2013.05.006
PG 6
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA 202SH
UT WOS:000323239400040
DA 2025-06-11
ER

PT J
AU Seo, DY
   Lee, S
   Figueroa, A
   Kim, HK
   Baek, YH
   Kwak, YS
   Kim, N
   Choi, TH
   Rhee, BD
   Ko, KS
   Park, BJ
   Park, SY
   Han, J
AF Seo, Dae Yun
   Lee, SungRyul
   Figueroa, Arturo
   Kim, Hyoung Kyu
   Baek, Yeong Ho
   Kwak, Yi Sub
   Kim, Nari
   Choi, Tae Hoon
   Rhee, Byoung Doo
   Ko, Kyung Soo
   Park, Byung Joo
   Park, Song Young
   Han, Jin
TI Yoga Training Improves Metabolic Parameters in Obese Boys
SO KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY
LA English
DT Article
DE Yoga (asana); Obesity; Body composition; Lipid profile; HOMA-IR
ID PHYSICAL-ACTIVITY; BODY-COMPOSITION; CARDIOVASCULAR-DISEASE;
   INSULIN-RESISTANCE; EXERCISE INTERVENTION; ABDOMINAL OBESITY; OXIDATIVE
   STRESS; RISK-FACTORS; WEIGHT-LOSS; HEART-RATE
AB Yoga has been known to have stimulatory or inhibitory effects on the metabolic parameters and to be uncomplicated therapy for obesity. The purpose of the present study was to test the effect of an 8-week of yoga-asana training on body composition, lipid profile, and insulin resistance (IR) in obese adolescent boys. Twenty volunteers with body mass index (BMI) greater than the 95th percentile were randomly assigned to yoga (age 14.7 +/- 0.5 years, n=10) and control groups (age 14.6 +/- 1.0 years, n=10). The yoga group performed exercises three times per week at 40 similar to 60% of heart-rate reserve (HRR) for 8 weeks. IR was determined with the homeostasis model assessment of insulin resistance (HOMA-IR). After yoga training, body weight, BMI, fat mass (FM), and body fat % (BF %) were significantly decreased, and fat-free mass and basal metabolic rate were significantly increased than baseline values. FM and BF % were significantly improved in the yoga group compared with the control group (p < 0.05). Total cholesterol (TC) was significantly decreased in the yoga group (p < 0.01). HDL-cholesterol was decreased in both groups (p < 0.05). No significant changes were observed between or within groups/for triglycerides, LDL-cholesterol, glucose, insulin, and HOMA-IR. Our findings show that an 8-week of yoga training improves body composition and TC levels in obese adolescent boys, suggesting that yoga training may be effective in controlling some metabolic syndrome factors in obese adolescent boys.
C1 [Seo, Dae Yun; Lee, SungRyul; Kim, Hyoung Kyu; Kim, Nari; Rhee, Byoung Doo; Ko, Kyung Soo; Han, Jin] Inje Univ, Coll Med, Cardiovasc & Metab Dis Ctr, Dept Physiol,Natl Res Lab Mitochondrial Signaling, Pusan 614735, South Korea.
   [Figueroa, Arturo; Park, Song Young] Florida State Univ, Coll Human Sci, Dept Nutr Food & Exercise Sci, Tallahassee, FL 32306 USA.
   [Baek, Yeong Ho] Pusan Natl Univ, Dept Phys Educ, Pusan 609735, South Korea.
   [Kwak, Yi Sub] Dong Eui Univ, Dept Phys Educ, Pusan 614714, South Korea.
   [Choi, Tae Hoon] Andong Sci Coll, Dept Sport & Leisure Studies, Andong 760709, South Korea.
   [Rhee, Byoung Doo; Ko, Kyung Soo] Inje Univ, Coll Med, Dept Internal Med, Seoul 100032, South Korea.
   [Park, Byung Joo] Dong Seo Univ, Div Leisure & Sports Sci, Pusan 617716, South Korea.
C3 Inje University; State University System of Florida; Florida State
   University; Pusan National University; Dong-Eui University; Inje
   University
RP Han, J (corresponding author), Inje Univ, Coll Med, Cardiovasc & Metab Dis Ctr, Dept Physiol,Natl Res Lab Mitochondrial Signaling, 633-165 Gaegeum Dong, Pusan 614735, South Korea.
EM phyhanj@inje.ac.kr
RI Figueroa, Arturo/ABH-3479-2021; Park, Byung-Joo/E-5438-2011; Kim,
   Jung-Wook/AAI-1668-2020; Kim, Hyung/J-5451-2012
OI Kim, Hyoung Kyu/0000-0002-1791-7865; Figueroa,
   Arturo/0000-0001-9710-038X; Seo, Dae Yun/0000-0002-4377-5792
FU Priority Research Centers Program through the National Research
   Foundation of Korea (NRF); Ministry of Education, Science and Technology
   [2010-0020224]
FX This work was supported by Priority Research Centers Program through the
   National Research Foundation of Korea (NRF) funded by the Ministry of
   Education, Science and Technology (2010-0020224).
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NR 59
TC 55
Z9 60
U1 0
U2 23
PU KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY
PI SEOUL
PA C/O EDITORIAL OFFICE, 448-13 SEOKYO-DONG, SEOUL, SOUTH KOREA
SN 1226-4512
EI 2093-3827
J9 KOREAN J PHYSIOL PHA
JI KOREAN J. PHYSIOL. PHARMACOL.
PD JUN
PY 2012
VL 16
IS 3
BP 175
EP 180
DI 10.4196/kjpp.2012.16.3.175
PG 6
WC Pharmacology & Pharmacy; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Physiology
GA 970TQ
UT WOS:000306155600004
PM 22802698
OA Green Published, hybrid, Green Submitted
DA 2025-06-11
ER

PT J
AU Probst-Hensch, NM
AF Probst-Hensch, Nicole M.
TI Chronic age-related diseases share risk factors: do they share
   pathophysiological mechanisms and why does that matter?
SO SWISS MEDICAL WEEKLY
LA English
DT Review
DE pathway; obesity; air pollution; public health; systemic inflammation;
   insulin; insulin-like growth factor; cell cycle; genomics
ID PARTICULATE AIR-POLLUTION; GENOME-WIDE ASSOCIATION; LONG-TERM EXPOSURE;
   INSULIN-RESISTANCE; GENETIC EPIDEMIOLOGY; POLYMORPHIC VARIANTS;
   METABOLIC SYNDROME; DIABETES-MELLITUS; OXIDATIVE STRESS; PATHWAY
   ANALYSIS
AB The World Health Organization (WHO) assigns high priority to the prevention of non-communicable age-related diseases such as heart disease, cancer, diabetes, stroke and chronic lower respiratory diseases. They are now the leading causes of death, in both industrialised and developing countries, mostly due to increased life expectancy and urbanisation with associated changes in lifestyle and environment. Tobacco smoking, physical inactivity and resulting obesity are established risk factors for many chronic diseases. Yet, the aetiology of age-related diseases is complex and varies between individuals. This often makes it difficult to identify causal risk factors, especially if their relative effects are weak. For example, the associations of both obesity and air pollution with several age-related diseases remain poorly understood with regard to causality and biological mechanisms. Exposure to both, excess body fat and particulate matter, is accompanied by systemic low-grade inflammation as well as alterations in insulin/insulin-like growth factor signalling and cell cycle control. These mechanisms have also been associated in animal and some human studies with longevity and ageing in more general terms. In this paper, it is therefore hypothesised that they may, at least in part, be responsible for the adverse health effects of obesity and air pollution. It is argued that molecular and genetic epidemiology now offer novel instruments to improve the understanding of these pathophysiological pathways and their link to disease aetiology. Understanding the causality of exposure disease associations and differences in susceptibilities to environment and lifestyle is an important aspect for effective prevention.
C1 [Probst-Hensch, Nicole M.] SwissTrop & Publ Hlth, Basel, Switzerland.
   [Probst-Hensch, Nicole M.] Univ Basel, Basel, Switzerland.
C3 Swiss School of Public Health (SSPH+); University of Basel; Swiss
   Tropical & Public Health Institute; University of Basel
RP Probst-Hensch, NM (corresponding author), SwissTrop & Publ Hlth, Basel, Switzerland.
EM Nicole.Probst@unibas.ch
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NR 77
TC 31
Z9 32
U1 0
U2 9
PU SMW supporting association
PI Basel
PA Tragerverein Swiss Medical Weekly, Malzgasse 15, Basel, SWITZERLAND
SN 1424-7860
EI 1424-3997
J9 SWISS MED WKLY
JI Swiss Med. Wkly.
PD AUG 14
PY 2010
VL 140
BP 26
EP 32
DI 10.4414/smw.2010.13072
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 662WG
UT WOS:000282844400004
PM 20809438
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Clark, VR
   Hill, OW
AF Clark, Vernessa R.
   Hill, Oliver W., Jr.
TI BODY MASS AND CARDIOVASCULAR REACTIVITY TO RACISM IN AFRICAN AMERICAN
   COLLEGE STUDENTS
SO ETHNICITY & DISEASE
LA English
DT Article
DE Body Mass; Cardiovascular Reactivity; Racially Noxious Stressor
ID INTERNALIZED RACISM; INSULIN-RESISTANCE; METABOLIC SYNDROME; ABDOMINAL
   OBESITY; STRESS; GENDER; RISK
AB Objective: The purpose of the present study was to examine the effects of body mass on cardiovascular reactivity to racism in African American college students.
   Design and Methods: Cardiac output, stroke volume, heart rate and blood pressure were measured as participants viewed a racially noxious scene on videotape. Body mass was measured using body mass index calculated using height and weight. We hypothesized that obese individuals would have greater cardiovascular reactivity to the scene than overweight individuals or individuals with normal weight. We also hypothesized that obese women would have the greatest cardiovascular reactivity to the scenes compared to overweight and normal weight women, and obese, overweight, and normal weight men. Lastly, we hypothesized that women would have greater cardiovascular reactivity than their male counterparts.
   Results: Multivariate analysis of variance revealed that obese participants had significantly greater stroke volume and cardiac output than participants of normal weight, indicating that obese participants were less emotionally aroused by the stressor. There was also a significant interaction between sex and body mass for heart rate reactivity between the stressor and recovery periods. Obese women had the largest drop in heart rate, while obese men had the smallest drop from the stressor period to the recovery period.
   Conclusions: The findings revealed that obese participants were less aroused by the stressors and recovered from them more quickly than overweight participants and participants of normal weight. The frequent experiences of weight prejudices by the obese group may have desensitized them to other prejudices such as the racial intolerance shown in the stressor. (Ethn Dis. 2009;19:2-6)
C1 [Clark, Vernessa R.; Hill, Oliver W., Jr.] Virginia State Univ, Dept Psychol, Petersburg, VA 23806 USA.
C3 Virginia State University
RP Clark, VR (corresponding author), Virginia State Univ, Dept Psychol, POB 9079, Petersburg, VA 23806 USA.
EM vrclark@vsu.edu
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NR 24
TC 8
Z9 9
U1 0
U2 8
PU INT SOC HYPERTENSION BLACKS-ISHIB
PI ATLANTA
PA 100 AUBURN AVE NE STE 401, ATLANTA, GA 30303-2527 USA
SN 1049-510X
EI 1945-0826
J9 ETHNIC DIS
JI Ethn. Dis.
PD WIN
PY 2009
VL 19
IS 1
BP 2
EP 6
PG 5
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA 423KB
UT WOS:000264494100002
PM 19341155
DA 2025-06-11
ER

PT J
AU Lambert, M
   O'Loughlin, J
   Delvin, EE
   Levy, E
   Chiolero, A
   Paradis, G
AF Lambert, Marie
   O'Loughlin, Jennifer
   Delvin, Edgard E.
   Levy, Emile
   Chiolero, Arnaud
   Paradis, Gilles
TI Association between insulin, leptin, adiponectin and blood pressure in
   youth
SO JOURNAL OF HYPERTENSION
LA English
DT Article
DE adiponectin; adolescent; blood pressure; child; insulin; leptin
ID OBESITY-RELATED HYPERTENSION; HOMEOSTASIS MODEL ASSESSMENT;
   CARDIOVASCULAR RISK-FACTORS; BODY-MASS INDEX; METABOLIC SYNDROME; PLASMA
   ADIPONECTIN; THERAPEUTIC INTERVENTIONS; OXIDATIVE STRESS; CHILDREN;
   ADOLESCENTS
AB Objective To examine whether insulin, leptin and adiponectin are independent correlates of blood pressure (BP) in a large population-based sample of children and adolescents.
   Methods We studied 655 boys and 667 girls aged 9,13 and 16 years who participated in the Quebec Child and Adolescent Health and Social Survey, a province-wide school-based survey conducted in 1999.
   Results Strong, positive univariate associations between l insulin and leptin Z-scores, and both systolic and diastolic BP were found in both sexes. Adiponectin Z-scores were negatively associated with systolic BID in girls only. In multivariate analyses only BMI and insulin Z-scores were significantly associated with systolic BP. In boys, each 1 SD increase in BMI was associated with a 4 mmHg increase in mean systolic BP; each 1 SD increase in insulin was associated with a 1 mmHg increase in mean systolic BP. Only insulin Z-scores were independently associated with diastolic BP in both sexes. For each 1 SD increase in insulin, there was a 1 mmHg increase in mean diastolic BP in boys. Similar to systolic BP, the magnitude of the effect of insulin Z-scores on diastolic BP increased as a function of BMI Z-scores in girls.
   Conclusion Independently of BMI, insulin is a strong correlate of systolic and diastolic BP in youth. Although animal studies support a role for leptin and adiponectin in controlling BP, they are not independently associated with BP in youth. J Hypertens 27:1025-1032 (C) 2009 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
C1 [Lambert, Marie] CHU St Justine, Med Genet Serv, Dept Pediat, Montreal, PQ H3T 1C5, Canada.
   [O'Loughlin, Jennifer] Univ Montreal, Ctr Rech CHUM, Dept Social & Prevent Med, Montreal, PQ, Canada.
   [Delvin, Edgard E.] Univ Montreal, Dept Clin Biochem, CHU St Justine, Montreal, PQ, Canada.
   [Levy, Emile] Univ Montreal, Dept Nutr, CHU St Justine, Montreal, PQ H3C 3J7, Canada.
   [Chiolero, Arnaud; Paradis, Gilles] McGill Univ, Dept Epidemiol Biostat & Occupat Hlth, Montreal, PQ, Canada.
C3 Universite de Montreal; Centre Hospitalier Universitaire Sainte-Justine;
   Universite de Montreal; Universite de Montreal; Centre Hospitalier
   Universitaire Sainte-Justine; Universite de Montreal; Centre Hospitalier
   Universitaire Sainte-Justine; McGill University
RP Lambert, M (corresponding author), CHU St Justine, Med Genet Serv, Dept Pediat, 3175 Cote St Catherine, Montreal, PQ H3T 1C5, Canada.
EM marie.lambert@umontreal.ca
RI Chiolero, Arnaud/A-4322-2010
OI Chiolero, Arnaud/0000-0002-5544-8510
FU Quebec Ministry of Health and Social Services, Health Canada; Canadian
   Institutes of Health Research; Swiss National Science Foundation
FX The survey was funded by the Quebec Ministry of Health and Social
   Services and by Health Canada. The study was funded by the Canadian
   Institutes of Health Research. J.O.L. holds a Canada Research Chair in
   the Childhood Determinants of Adult Chronic Disease. G.P. holds an
   Applied Public Health Chair of the Canadian Institutes of Health
   Research. A.C. holds a fellowship from the Swiss National Science
   Foundation and from the Canadian Institutes of Health Research.
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   Yanai H, 2008, NUTR J, V7, DOI 10.1186/1475-2891-7-10
NR 54
TC 23
Z9 26
U1 1
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0263-6352
EI 1473-5598
J9 J HYPERTENS
JI J. Hypertens.
PD MAY
PY 2009
VL 27
IS 5
BP 1025
EP 1032
DI 10.1097/HJH.0b013e32832935b6
PG 8
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 443VO
UT WOS:000265939100015
PM 19293727
DA 2025-06-11
ER

PT J
AU Heber, MF
   Ferreira, SR
   Vélez, LM
   Motta, AB
AF Heber, Mara F.
   Ferreira, Silvana R.
   Velez, Leandro M.
   Motta, Alicia B.
TI Prenatal hyperandrogenism and lipid profile during different age stages:
   an experimental study
SO FERTILITY AND STERILITY
LA English
DT Article
DE Prenatal hyperandrogenization; lipid profile; peroxisome
   proliferator-activated receptor gamma; ovarian oxidative stress
ID POLYCYSTIC-OVARY-SYNDROME; IMPAIRED GLUCOSE-TOLERANCE;
   ACTIVATED-RECEPTOR-GAMMA; ANTI-MULLERIAN HORMONE; OXIDATIVE STRESS;
   INSULIN SENSITIVITY; DIABETES-MELLITUS; PRECOCIOUS PUBARCHE;
   CARDIOVASCULAR RISK; METABOLIC SYNDROME
AB Objective: The present study investigates the effect of prenatal hyperandrogenization on lipid metabolism and oxidant/antioxidant balance.
   Design: Experimental study.
   Setting: Research institute.
   Animal(s): Pregnant Sprague Dawley rats were subcutaneously injected with 2 mg free T between days 16 and 19 of pregnancy, and controls (C) received vehicle (0.1 mL of sesame oil). Prenatally hyperandrogenized female offspring (T2) had a condition that resembles polycystic ovary (PCO). Animals were weighed and killed at 21 and 60 days of age (N = 15 rats/group).
   Intervention(s): Ovarian tissue and truncal blood were obtained from the C and T2 groups.
   Main Outcome Measure(s): Circulating lipid profile (total cholesterol, high-density lipoprotein [HDL], low-density lipoprotein [LDL] cholesterol, and triglycerides) was quantified by colorimetric-enzymatic methods. Ovarian oxidative stress was evaluated by quantifying lipid peroxidation and glutathione content by spectofotometric assays. Ovarian fat content was evaluated by Red Oil staining and ovarian messenger RNA (mRNA) expression of peroxisome proliferator-activated receptor gamma (PPAR-gamma) by real-time polymerase chain reaction (PCR).
   Result(s): At 60 days of age, 100% of group C rats and 20% of group T2 rats ovulated. At 21 days of age the T2 rats displayed lower body weight than C rats; however, at 60 days of age T2 and C rats showed similar body weights. The lipid profile (total cholesterol, LDL cholesterol, HDL cholesterol, and triglycerides) was altered in the anovulatory and ovulatory phenotype of the T2 group, but the levels were higher in the anovulatory phenotype. Lipid peroxidation of rats at 21 and 60 days of age from T2 was similar to C but the antioxidant glutathione level was decreased in 21-day-old rats compared with C rats. The lipid content of ovarian tissue, determined by Red Oil staining, was higher in the T2 than in the C group. The mRNA expression of ovarian PPAR-gamma, quantified by real time PCR, decreased in anovulatory rats at 60 days of age from T2 compared to C rats.
   Conclusion(s): Our findings reveal the importance of evaluating the complete lipid profile, especially at early stages of life after the prenatal hyperandrogenism condition. In addition, we demonstrated that the antioxidant-reduced glutathione would represent a good marker of oxidative stress as it is altered before lipid peroxidation. Prenatal hyperandrogenization also alters the gene expression of PPAR-gamma in rats. Here we demonstrated for the first time that abnormalities in PPAR-gamma and lipid profile were higher in rats showing an anovulatory phenotype than those displaying an ovulatory phenotype. (Fertil Steril (R) 2013;99: 551-7. (C) 2013 by American Society for Reproductive Medicine.)
C1 [Heber, Mara F.; Ferreira, Silvana R.; Velez, Leandro M.; Motta, Alicia B.] Consejo Nacl Invest Cient & Tecnol CONICET, Ctr Estudios Farmacol & Bot CEFYBO, Lab Fisiopatol Ovar, Buenos Aires, DF, Argentina.
C3 Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET)
RP Motta, AB (corresponding author), Univ Buenos Aires, Fac Med, Paraguay 2155, RA-1121 Buenos Aires, DF, Argentina.
EM aliciabmotta@yahoo.com.ar
RI Velez, Leandro/V-8791-2019; Heber, Maria/AEF-4326-2022
OI Heber, Maria Florencia/0000-0002-2392-3671; Velez, Leandro
   Martin/0000-0001-8371-2633; Motta, Alicia/0000-0002-8478-728X
FU Ministry of Science and Technology; Agencia Nacional de Promocion
   Cientifica y Tecnologica [PICT 71/2010]; Consejo Nacional de
   Investigaciones Cientificas y Tecnicas (CONICET) [PIP 185]
FX M.F.H. reports grants and travel support from the Ministry of Science
   and Technology. S.R.F. reports grants and travel support from the
   Ministry of Science and Technology. L.M.V. reports grants and travel
   support from the Ministry of Science and Technology. A.B.M. reports
   grants and travel support from the Ministry of Science and Technology.
   Supported by Agencia Nacional de Promocion Cientifica y Tecnologica
   (grant PICT 71/2010) and Consejo Nacional de Investigaciones Cientificas
   y Tecnicas (CONICET) PIP 185.
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NR 65
TC 17
Z9 18
U1 0
U2 5
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0015-0282
EI 1556-5653
J9 FERTIL STERIL
JI Fertil. Steril.
PD FEB
PY 2013
VL 99
IS 2
BP 551
EP 557
DI 10.1016/j.fertnstert.2012.10.017
PG 7
WC Obstetrics & Gynecology; Reproductive Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology; Reproductive Biology
GA 086DC
UT WOS:000314662400045
PM 23122950
OA Green Published
DA 2025-06-11
ER

PT J
AU Kaine, J
   Song, X
   Kim, G
   Hur, P
   Palmer, JB
AF Kaine, Jeffrey
   Song, Xue
   Kim, Gilwan
   Hur, Peter
   Palmer, Jacqueline B.
TI Higher Incidence Rates of Comorbidities in Patients with Psoriatic
   Arthritis Compared with the General Population Using US Administrative
   Claims Data
SO JOURNAL OF MANAGED CARE & SPECIALTY PHARMACY
LA English
DT Article
ID METABOLIC SYNDROME; MULTINATIONAL ASSESSMENT; RHEUMATOID-ARTHRITIS;
   DIABETES-MELLITUS; PREVALENCE; DISEASE; EPIDEMIOLOGY; BURDEN; INDEX;
   RISK
AB BACKGROUND: Psoriatic arthritis (PsA) is associated with multiple comorbid conditions, including cardiovascular (CV) comorbidities that impose a considerable burden on patients. Effective management of PsA requires an understanding of comorbidity profiles.
   OBJECTIVE: To compare the frequency and incidence rates of comorbidities and hospitalizations among newly diagnosed PsA patients and a matched general population without PsA, using large national claims databases in the United States.
   METHODS: This retrospective observational study used MarketScan databases from January 1, 2008, to September 30, 2015, to identify adult patients with newly diagnosed PsA (i.e., no PsA diagnosis during the 1 year before the first observed PsA diagnosis). The earliest date of PsA diagnosis was defined as the index date. Patients with no PsA diagnosis any time during the study period (controls) were directly matched to PsA patients with demographic characteristics. All patients had >= 2 years of medical and pharmacy coverage before the index date and >= 1 year of follow-up. Incident rates per 100 person-years for comorbidities of interest were evaluated. The hazard ratios of having various comorbid conditions for PsA patients were estimated by Cox proportional hazards models. All-cause and CV-related hospitalizations during the follow-up period were evaluated.
   RESULTS: A total of 14,898 PsA patients and 35,037 matched controls met the study criteria. Compared with controls, PsA patients had a higher risk of CV disorders (incidence rate = 6.5 vs. 5.8; HR = 1.46; 95% CI = 1.37-1.56) and a higher risk of the majority of the specific CV disorders (hypertension, hyperlipidemia, coronary artery disease, cerebrovascular disease, peripheral vascular disease). PsA patients also had a higher risk for any autoimmune disease (incidence rate = 8.4 vs. 1.6; HR = 18.26; 95% CI = 17.18-19.40) and most autoimmune categories (psoriasis, ankylosing spondylitis, rheumatoid arthritis, multiple sclerosis, and other autoimmune disorders). Rates of other PsA-related comorbidities (diabetes, anxiety, fatigue, smoking, alcohol use, obesity or overweight, depression, osteoporosis, uveitis, eczema, and gout) were also significantly higher for PsA patients. The all-cause hospitalization rate was higher among PsA patients than controls (24.9% vs. 16.2%; P < 0.001). The CV-related hospitalization rate varied depending on whether the CV condition was the primary discharge diagnosis only or was any diagnosis on the inpatient claims. The rates of coronary artery disease hospitalizations were significantly higher in PsA patients than in controls with both methods of analysis (primary diagnosis: 0.8% vs. 0.5%; P < 0.001; nonprimary diagnosis: 3.2% vs. 2.2%; P < 0.001).
   CONCLUSIONS: This retrospective U.S.-based claims study found that PsA patients had a high comorbidity burden. Compared with the non-PsA population, PsA patients were associated with a higher incidence of CV comorbidities, autoimmune diseases, and other PsA-related comorbidities and a higher rate of all-cause and CV-related hospitalizations. Understanding these comorbidity profiles may provide insight on the effect of comorbid conditions on disease management and health care utilization associated with PsA. Copyright (C) 2019, Academy of Managed Care Pharmacy. All rights reserved.
C1 [Kaine, Jeffrey] Sarasota Arthrit Res Ctr, Sarasota, FL USA.
   [Song, Xue; Kim, Gilwan] Truven Hlth Analyt, 5 Binney St, Cambridge, MA 02142 USA.
   [Hur, Peter; Palmer, Jacqueline B.] Novartis, E Hanover, NJ USA.
C3 Novartis; Novartis USA
RP Song, X (corresponding author), Truven Hlth Analyt, 5 Binney St, Cambridge, MA 02142 USA.
EM songx@us.ibm.com
RI palmer, jacqueline/GRR-3935-2022
FU Novartis
FX This study was funded by Novartis. Kaine is a paid consultant for
   Novatis. Hur and Palmer are Novartis employees and stockowners. Song and
   Kim work for Truven Health Analytics, which received funding from
   Novartis to conduct this study.
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NR 37
TC 83
Z9 88
U1 0
U2 5
PU ACAD MANAGED CARE PHARMACY
PI ALEXANDRIA
PA 100 N PITT ST, 400, ALEXANDRIA, VA 22314-3134 USA
SN 2376-0540
EI 2376-1032
J9 J MANAG CARE SPEC PH
JI J. Manag. Care Spec. Pharm.
PD JAN
PY 2019
VL 25
IS 1
BP 122
EP 132
PG 11
WC Health Care Sciences & Services; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Health Care Sciences & Services; Pharmacology & Pharmacy
GA HF7TE
UT WOS:000454442700016
PM 29694270
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Marino, AG
   Gentile, G
   Lenci, L
   De Benedetto, F
   Tremamunno, S
   Cambise, N
   Belmusto, A
   Di Renzo, A
   Tinti, L
   De Vita, A
   Lanza, GA
AF Marino, Angelo Giuseppe
   Gentile, Giuseppe
   Lenci, Ludovica
   De Benedetto, Fabio
   Tremamunno, Saverio
   Cambise, Nello
   Belmusto, Antonietta
   Di Renzo, Antonio
   Tinti, Lorenzo
   De Vita, Antonio
   Lanza, Gaetano Antonio
TI Comparison of Baseline and Post-Nitrate Exercise Testing in Patients
   with Angina but Non-Obstructed Coronary Arteries with Different
   Acetylcholine Test Results
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Article
DE angina syndromes; non-obstructive coronary artery disease; exercise
   stress test; acetylcholine test; nitrates
ID TERM-FOLLOW-UP; MICROVASCULAR DYSFUNCTION; MYOCARDIAL-INFARCTION; STABLE
   ANGINA; SYNDROME-X; DISEASE; PERFUSION; PECTORIS; SAFETY
AB Background: Intracoronary acetylcholine testing may induce epicardial coronary artery spasm (CAS) or coronary microvascular spasm (CMVS) in patients with angina syndromes but non-obstructive coronary artery disease, but their causal role in individual patients is not always clear. In this prospective, observational single-center study, we aimed to assess whether (1) the induction of myocardial ischemia/angina by electrocardiogram (ECG) exercise stress test (EST) differs between patients showing different results in response to acetylcholine testing (i.e., CAS, CMVS, or no spasm); (2) the preventive administration of short-acting nitrates has any different effects on the EST of those patients who showed a positive basal EST. We expected that if exercise-induced angina and/or ischemic ECG changes are related to CAS, they should improve after nitrates administration, whereas they should not significantly improve if they are caused by CMVS. Methods: We enrolled 81 patients with angina syndromes and non-obstructive coronary artery disease, who were divided into three groups according to acetylcholine testing: 40 patients with CAS (CAS-group), 14 with CMVS (CMVS-groups), and 27 with a negative test (NEG-group). All patients underwent a basal EST (B-EST). Patients with a positive B-EST repeated the test 24-48 h later, 5 min after the administration of short-acting nitrates (N-EST). Results: There were no significant differences among the groups in terms of the B-EST results. B-EST was positive in eight (20%) patients in the CAS-group, seven (50%) in the CMVS-group, and six (22%) in the NEG-group (p = 0.076). N-EST, performed in eight, six, and five of these patients, also showed similar results in the three groups. Furthermore, the N-EST results also did not significantly differ compared to B-EST in any group, remaining positive in seven (87.5%), four (66.7%), and four (80%) patients in the CAS-group, CMVS-group, and NEG-group, respectively (p = 0.78). Conclusions: Our data show that patients with angina and non-obstructive coronary artery disease show largely comparable results of the ECG exercise stress test and similar poor effects of short-acting nitrates on abnormal ECG exercise stress test results. On the whole, our findings suggest caution in attributing to the results of Ach testing a definite causal role for the clinical syndrome in individual patients.
C1 [Marino, Angelo Giuseppe; Gentile, Giuseppe; Lenci, Ludovica; De Benedetto, Fabio; Tremamunno, Saverio; Cambise, Nello; Belmusto, Antonietta; Di Renzo, Antonio; Tinti, Lorenzo; Lanza, Gaetano Antonio] Univ Cattolica Sacro Cuore, Dipartimento Sci Cardiovascolari & Torace, I-00168 Rome, Italy.
   [De Vita, Antonio; Lanza, Gaetano Antonio] Fdn Policlin Univ A Gemelli IRCCS, I-00168 Rome, Italy.
C3 Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli;
   Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli
RP Lanza, GA (corresponding author), Univ Cattolica Sacro Cuore, Dipartimento Sci Cardiovascolari & Torace, I-00168 Rome, Italy.; Lanza, GA (corresponding author), Fdn Policlin Univ A Gemelli IRCCS, I-00168 Rome, Italy.
EM antonio.devita90@gmail.com; Gaetanoantonio.lanza@unicatt.it
RI Lanza, Gaetano/AAC-2660-2019; De Vita, Antonio/LRC-4736-2024; Gentile,
   Giuseppe/ABA-3941-2021
OI Lanza, Gaetano Antonio/0000-0003-2187-6653; Tremamunno,
   Saverio/0000-0002-6837-6464; De Vita, Antonio/0000-0001-8725-7447;
   Marino, Angelo Giuseppe/0009-0006-6588-6035
CR [Anonymous], 2010, NICE Guidelines Recent-Onset Chest Pain of Suspected Cardiac Origin: Assessment and Diagnosis
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NR 30
TC 0
Z9 0
U1 0
U2 1
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD APR
PY 2024
VL 13
IS 8
AR 2181
DI 10.3390/jcm13082181
PG 9
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA OV3C9
UT WOS:001210006100001
PM 38673454
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Jia, XJ
   Yu, Y
   Xia, WN
   Masri, S
   Sami, M
   Hu, ZX
   Yu, ZX
   Wu, J
AF Jia, Xianjie
   Yu, Ying
   Xia, Wanning
   Masri, Shahir
   Sami, Mojgan
   Hu, Zhixiong
   Yu, Zhaoxia
   Wu, Jun
TI Cardiovascular diseases in middle aged and older adults in China: the
   joint effects and mediation of different types of physical exercise and
   neighborhood greenness and walkability
SO ENVIRONMENTAL RESEARCH
LA English
DT Article
DE Cardiovascular diseases; Physical exercise; Older adults; Built
   environment; Greenness; Walkability
ID CARDIOMETABOLIC RISK-FACTORS; BUILT ENVIRONMENT; MENTAL-HEALTH;
   NONCOMMUNICABLE DISEASES; COMMUNITY DESIGN; ASSOCIATIONS; GREENSPACE;
   OBESITY; HYPERTENSION; PATHWAYS
AB Background: Both physical exercise and the built environment are associated with cardiovascular diseases (CVDs). Yet, the influence of the multiple dimensions of the built environment and different types of physical exercise on CVDs is not well understood. Further, little is known about the joint effects of physical exercise and the built environment, nor whether one mediates the effect of the other on the risk of CVDs. We aim to investigate the risk of CVDs on middle aged and older Chinese adult populations by analyzing the independent effects, as well as potential interactions and mediation effects of different types of physical exercise and two dimensions of the built environment; namely, greenness and walkability.
   Methods: Data were collected from a community-based cross-sectional study (n = 1944). The study participants, aged 40 years or older, came from 32 communities across urban, suburban, and rural areas in Longzihu district of Bengbu, a typical second-tier city in eastern China. Physical exercise data were obtained from the International Physical Activity Questionnaire (IPAQ) question survey. We used a satellite-based Normalized Difference Vegetation Index (NDVI) score to assess greenness exposure. We used both the Walk Score index and the Neighborhood Environment Walkability Scale (NEWS) to assess walkability. Multilevel logistic regression, also known as mixed-effects logistic regression, was used to estimate the associations between physical exercise and the built environment (greenness and walkability) on CVD outcomes while accounting for within-community and within-subdistrict correlations. We followed Baron and Kenny's framework and used bootstrapping to quantify the mediation of physical exercise between built environment and CVD outcomes. Stratified analysis was conducted by age (middle aged and older adults) and gender.
   Results: Compared to the reference group with little to low physical activities, we found a significantly reduced risk of hypertension (about 20-45% reduction) and coronary heart disease (about 35-55% reduction) among those with moderate to high activities in walking/square dancing or morning exercising/Tai Chi, and a significantly reduced risk of stroke (about 25% reduction) among those with moderate to high activities in walking/square dancing. Compared to the reference group with low NDVI-based greenness exposure, we found a significant reduction in risk of hypertension (about 55-85% reduction), coronary heart disease (about 75% reduction) and stroke (about 45% reduction) among those with moderate to high levels of exposure. Compared to the reference groups with low walkability, we observed about 30-60% lower risk of hypertension and coronary heart disease associated with moderate to high levels of Walk score, and about 20-30% lower risk of hypertension and stroke associated with moderate to high levels of NEWS-based walkability. We found no interactions between physical exercise and the built environment. The associations of greenness and walkability with CVDs were partially explained by physical exercise (up to 55% of the total effect).
   Conclusions: Both physical exercise and built environment factors were associated with the risk of CVDs. Our observed association between CVDs and neighborhood greenness exposure and walkability was explained, in part, by physical exercises. Such a role, if confirmed in future studies, could have important implications for policies and programs aimed at increasing green spaces and improving walkability in both urban and rural settings as strategies to promote physical exercise in middle aged and older population.
C1 [Jia, Xianjie; Xia, Wanning] Bengbu Med Coll, Dept Epidemiol & Biostat, Bengbu, Peoples R China.
   [Yu, Ying] Bengbu Med Coll, Dept Physiol, Bengbu, Peoples R China.
   [Masri, Shahir; Sami, Mojgan; Wu, Jun] Univ Calif Irvine, Susan & Henry Samueli Coll Hlth Sci, Program Publ Hlth, Irvine, CA 92717 USA.
   [Hu, Zhixiong; Yu, Zhaoxia] Univ Calif Irvine, Dept Stat, Irvine, CA USA.
C3 Bengbu Medical University; Bengbu Medical University; University of
   California System; University of California Irvine; University of
   California System; University of California Irvine
RP Wu, J (corresponding author), Univ Calif Irvine, Susan & Henry Samueli Coll Hlth Sci, Program Publ Hlth, Irvine, CA 92717 USA.
EM junwu@uci.edu
RI Hu, Zhixiong/ITU-5508-2023; wanning, Xia/IXD-9842-2023
OI Ying, Yu/0000-0003-0925-0148; Xia, Wanning/0000-0001-5783-459X
FU Natural Science Foundation of Anhui Province [1508085QH150]; Natural
   Science of the Education Department of Anhui Province, China
   [KJ2017A217]
FX This work was supported by the Natural Science Foundation of Anhui
   Province (1508085QH150), and the Natural Science of the Education
   Department of Anhui Province (KJ2017A217), China.
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NR 86
TC 114
Z9 125
U1 11
U2 206
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0013-9351
EI 1096-0953
J9 ENVIRON RES
JI Environ. Res.
PD NOV
PY 2018
VL 167
BP 175
EP 183
DI 10.1016/j.envres.2018.07.003
PG 9
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA GW8RP
UT WOS:000447247500018
PM 30029039
DA 2025-06-11
ER

PT J
AU Babkair, LA
   Safhi, RA
   Balshram, R
   Safhei, R
   Almahamdy, A
   Hakami, FH
   Alsaleh, AM
AF Babkair, Lisa A.
   Safhi, Razan A.
   Balshram, Raghad
   Safhei, Rahaf
   Almahamdy, Atheer
   Hakami, Fatimah Hamad
   Alsaleh, Ali Matouq
TI Nursing Care for Stroke Patients: Current Practice and Future Needs
SO NURSING REPORTS
LA English
DT Article
DE critical care; nursing training; nursing practice; stroke; stroke
   patients; stroke unit
ID ACUTE ISCHEMIC-STROKE; POSTSTROKE; SCALE; REHABILITATION; PROFESSIONALS;
   GUIDELINES; STATEMENT; UPDATE
AB Background: Stroke is the second leading cause of death and the third leading cause of disability worldwide. Stroke nurses play an important role in the care of patients living with stroke by using best practices and adhering to stroke-management guidelines. This study aims at examining the current nursing practice for stroke patients in Saudi Arabia. Method: A cross-sectional descriptive design was used to collect data from nurses working in the stroke unit and intensive care unit between the period of February and June 2022 using electronic self-administered questionnaires. Results: A convenience sample of 131 nurses who provided care for stroke patients was enrolled. Significant differences in nursing practice were found between the stroke units and the intensive care units regarding the activation of the stroke code, X-2 (4, N = 131) = 48.34, p < 0.001; transferring stroke patients to a designated bed, X-2 (4, N = 131) = 48.74, p = 0.002; applying the NIHSS, X-2 (4, N = 131) = 70.11, p < 0.001; using the modified Rankin scale, X-2 (4, N = 131) = 61.24, p < 0.001; providing intervention for neglect syndrome, X-2 (4, N = 131) = 44.72, and hemianopsia, X-2 (4, N = 131) = 39.22; screening for poststroke depression, X-2 (4, N = 131) = 101.59, p < 0.001; assessing for psychosocial needs, X-2 (4, N = 131) = 74.44, p < 0.001, and encouraging patients to express their feelings, X-2 (4, N = 131) = 58.64, p < 0.001; educating patients and families about stroke prevention, X-2 (4, N = 131) = 40.51, p < 0.001. Conclusion: As per the results of the study, there is an urgent need for stroke units run by specialized stroke nurses to provide early stroke management and improve survivors' outcomes. Structured stroke-care programs are needed to improve nursing practice and meet the international standard of stroke care.Background: Stroke is the second leading cause of death and the third leading cause of disability worldwide. Stroke nurses play an important role in the care of patients living with stroke by using best practices and adhering to stroke-management guidelines. This study aims at examining the current nursing practice for stroke patients in Saudi Arabia. Method: A cross-sectional descriptive design was used to collect data from nurses working in the stroke unit and intensive care unit between the period of February and June 2022 using electronic self-administered questionnaires. Results: A convenience sample of 131 nurses who provided care for stroke patients was enrolled. Significant differences in nursing practice were found between the stroke units and the intensive care units regarding the activation of the stroke code, X-2 (4, N = 131) = 48.34, p < 0.001; transferring stroke patients to a designated bed, X-2 (4, N = 131) = 48.74, p = 0.002; applying the NIHSS, X-2 (4, N = 131) = 70.11, p < 0.001; using the modified Rankin scale, X-2 (4, N = 131) = 61.24, p < 0.001; providing intervention for neglect syndrome, X-2 (4, N = 131) = 44.72, and hemianopsia, X-2 (4, N = 131) = 39.22; screening for poststroke depression, X-2 (4, N = 131) = 101.59, p < 0.001; assessing for psychosocial needs, X-2 (4, N = 131) = 74.44, p < 0.001, and encouraging patients to express their feelings, X-2 (4, N = 131) = 58.64, p < 0.001; educating patients and families about stroke prevention, X-2 (4, N = 131) = 40.51, p < 0.001.
   Conclusion: As per the results of the study, there is an urgent need for stroke units run by specialized stroke nurses to provide early stroke management and improve survivors' outcomes. Structured stroke-care programs are needed to improve nursing practice and meet the international standard of stroke care.
C1 [Babkair, Lisa A.; Safhi, Razan A.; Balshram, Raghad; Safhei, Rahaf; Almahamdy, Atheer] King AbdulAziz Univ, Fac Nursing, Jeddah 21589, Saudi Arabia.
   [Hakami, Fatimah Hamad] King Fahad Gen Hosp, Jeddah 23325, Saudi Arabia.
   [Alsaleh, Ali Matouq] King Fahad Med City, Natl Neurosci Inst Nursing Adm, Riyadh 12231, Saudi Arabia.
C3 King Abdulaziz University; King Fahd Hospital Jeddah; King Fahad Medical
   City
RP Babkair, LA (corresponding author), King AbdulAziz Univ, Fac Nursing, Jeddah 21589, Saudi Arabia.
EM lbabkair@kau.edu.sa; rsafhi0002@stu.kau.edu.sa; rblsharm@stu.kau.edu.sa;
   rsafhi0001@stu.kau.edu.sa; aalmahamdy0001@stu.kau.edu.sa;
   fatimahhh@moh.gov.sa; amalsaleh@kfmc.med.sa
RI Babkair, Lisa/ABE-8387-2021
OI Babkair, Lisa/0000-0003-0557-898X; Alsaleh, Ali/0000-0003-3045-3062
FU The authors want to acknowledge the efforts of the research assistant
   who facilitated the data collection.
FX The authors want to acknowledge the efforts of the research assistant
   who facilitated the data collection.
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NR 36
TC 2
Z9 2
U1 8
U2 27
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 2039-439X
EI 2039-4403
J9 NURS REP
JI Nurs. Rep.
PD SEP
PY 2023
VL 13
IS 3
BP 1236
EP 1250
DI 10.3390/nursrep13030106
PG 15
WC Nursing
WE Emerging Sources Citation Index (ESCI)
SC Nursing
GA S8WP1
UT WOS:001073919200001
PM 37755349
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Del Pinto, R
   Viazzi, F
   Pontremoli, R
   Ferri, C
   Carubbi, F
   Russo, E
AF Del Pinto, Rita
   Viazzi, Francesca
   Pontremoli, Roberto
   Ferri, Claudio
   Carubbi, Francesco
   Russo, Elisa
TI The URRAH study
SO PANMINERVA MEDICA
LA English
DT Article
DE Uric acid; Heart disease risk factors; Mortality
ID SERUM URIC-ACID; CARDIOVASCULAR SAFETY; METABOLIC SYNDROME; GOUT;
   HYPERURICEMIA; RISK; HYPERTENSION; ALLOPURINOL; PREVALENCE; FEBUXOSTAT
AB BACKGROUND: Uric acid has long been considered responsible for a single specific disease, namely gout. In recent years, novel knowledge has emerged linking serum uric acid with a variety of conditions and related risk factors, from hypertension, metabolic syndrome, and type 2 diabetes, to fatal/nonfatal cardiovascular diseases and all-cause death, with the underlying mechanisms involving disrupted neurohormonal and metabolic signaling as well as oxidative stress and inflammation. Importantly, the cut-off value of serum uric acid that predicts the risk of incident events is within the range of normality and below the threshold for increased risk of gout. A large contribution to the advancement in knowledge in the cardiovascular implications of uric acid derives from the Italian study URic acid Right for heArt Health (URRAH).
   METHODS: The URRAH study is an Italian nationwide, multicenter retrospective, observational cohort study combining data from outpatients attending hypertension clinics, as well as individuals recruited in prospective observational cohort studies with a follow-up period of at least 20 years up to July 31st, 2017. Data were retrospectively collected from different databases. At the end of the follow-up, the following hard endpoints were evaluated: fatal myocardial infarction; non-fatal acute myocardial infarction; heart failure; fatal stroke; non-fatal stroke; coronary revascularization.
   RESULTS: A total of 22,714 subjects were included in the analysis. During a median follow-up time of 134 months, a total of 3279 deaths were recorded, of which 1571 were due to cardiovascular causes. Multivariate Cox regression analyses identified an independent association between serum uric acid concentrations and both total (HR=1.53, 95% CI 1.21-1.93, P<0.001) and cardiovascular deaths (HR=2.08, 95% CI 1.146-2.97; P<0.001). Of note, the cut-off values of serum uric acid that were identified as those able to predict total mortality were largely within the normal range (4.7 mg/dL, 95% CI 4.3-5.1 mg/dL). Similarly, the cut-off value that better predicted cardiovascular death was within the normal range (5.6 mg/dL, 95% CI 4.99-6.21 mg/dL). The information on serum uric acid levels provided a significant net reclassification improvement of 0.26 and 0.27 over the Heart Score risk chart for total and cardiovascular mortality, respectively (P<0.001). Serum uric acid levels >= 4.7 or <4.7 mg/ dL incrementally predicted all-cause mortality over the Heart Score.
   CONCLUSIONS: The results of studies from the URRAH database further strengthen the role of uric acid in cardiovascular disease, including heart failure, and total mortality. The identified cut-off values support clinicians in investigating serum uric acid levels in their patients and to consider uric acid as an additional cardiovascular risk factor. Taken together, the published papers deriving from the URRAH database emphasize the role of uric acid in favoring cardiovascular events, and strongly suggest the existence of "grey" areas, i.e. close but lower than the "traditional" threshold for hyperuricemia, which deserve further characterization.
C1 [Del Pinto, Rita; Ferri, Claudio; Carubbi, Francesco] Univ Aquila, Dept Clin Med Publ Hlth Life & Environm Sci, I-67100 Laquila, Italy.
   [Viazzi, Francesca; Pontremoli, Roberto; Russo, Elisa] Univ Genoa, Dept Internal Med & Med Specialties, Genoa, Italy.
C3 University of L'Aquila; University of Genoa
RP Ferri, C (corresponding author), Univ Aquila, Dept Clin Med Publ Hlth Life & Environm Sci, I-67100 Laquila, Italy.
EM claudio.ferri@univaq.it
RI Russo, Elisa/AAH-2246-2021; Viazzi, Francesca/AAB-2479-2019
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NR 48
TC 24
Z9 24
U1 0
U2 4
PU EDIZIONI MINERVA MEDICA
PI TURIN
PA CORSO BRAMANTE 83-85 INT JOURNALS DEPT., 10126 TURIN, ITALY
SN 0031-0808
EI 1827-1898
J9 PANMINERVA MED
JI Panminerva Medica
PD DEC
PY 2021
VL 63
IS 4
BP 416
EP 423
DI 10.23736/S0031-0808.21.04357-3
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA YX1DH
UT WOS:000753848300003
PM 33765764
DA 2025-06-11
ER

PT J
AU Calderón-Garcidueñas, L
   Franco-Lira, M
   D'Angiulli, A
   Rodríguez-Díaz, J
   Blaurock-Busch, E
   Busch, Y
   Chao, CK
   Thompson, C
   Mukherjee, PS
   Torres-Jardón, R
   Perry, G
AF Calderon-Garciduenas, Lilian
   Franco-Lira, Maricela
   D'Angiulli, Amedeo
   Rodriguez-Diaz, Joel
   Blaurock-Busch, Eleonore
   Busch, Yvette
   Chao, Chih-kai
   Thompson, Charles
   Mukherjee, Partha S.
   Torres-Jardon, Ricardo
   Perry, George
TI Mexico City normal weight children exposed to high concentrations of
   ambient PM2.5 show high blood leptin and endothelin-1,
   vitamin D deficiency, and food reward hormone dysregulation versus low
   pollution controls. Relevance for obesity and Alzheimer disease
SO ENVIRONMENTAL RESEARCH
LA English
DT Article
DE Alzheimer; Children; Fructose; Leptin; APOE; PM2.5 Air pollution; Mexico
   City; Obesity; Vitamin D
ID CARDIOMETABOLIC RISK-FACTORS; URBAN AIR-POLLUTION; C-PEPTIDE LEVELS;
   SYSTEMIC INFLAMMATION; OXIDATIVE STRESS; GLUCOSE-LEVELS;
   INSULIN-RESISTANCE; COGNITIVE FUNCTION; BODY-WEIGHT; MOUSE MODEL
AB Millions of Mexico, US and across the world children are overweight and obese. Exposure to fossil-fuel combustion sources increases the risk for obesity and diabetes, while long-term exposure to fine particulate matter (PM2.5) and ozone (O-3) above US EPA standards is associated with increased risk of Alzheimer's disease (AD). Mexico City Metropolitan Area children are chronically exposed to PM2.5 and 03 concentrations above the standards and exhibit systemic, brain and intrathecal inflammation, cognitive deficits, and Alzheimer disease neuropathology. We investigated adipokines, food reward hormones, endothelial dysfunction, vitamin D and apolipoprotein E (APOE) relationships in 80 healthy, normal weight 11.1 +/- 3.2 year olds matched by age, gender, BMI and SES, low (n: 26) versus high (n:54) PM2.5 exposures. Mexico City children had higher leptin and endothelin-1 (p < 0.01 and p < 0.000), and decreases in glucagon-like peptide-1 (GLP 1), ghrelin, and glucagon ( < 0.02) versus controls. BMI and leptin relationships were significantly different in low versus high PM2.5 exposed children. Mexico City APOE 4 versus 3 children had higher glucose (p=0.009). Serum 25-hydroxyvitamin D < 30 ng/mL was documented in 87% of Mexico City children. Leptin is strongly positively associated to PM 2,5 cumulative exposures. Residing in a high PM2.5 and O-3 environment is associated with 12 h fasting hyperleptinemia, altered appetite-regulating peptides, vitamin D deficiency, and increases in ET-1 in clinically healthy children. These changes could signal the future trajectory of urban children towards the development of insulin resistance, obesity, type II diabetes, premature cardiovascular disease, addiction-like behavior, cognitive impairment and Alzheimer's disease. Increased efforts should be made to decrease pediatric PM2.5 exposures, to deliver health interventions prior to the development of obesity and to identify and mitigate environmental factors influencing obesity and Alzheimer disease. (C) 2015 Elsevier Inc. All rights reserved.
C1 [Calderon-Garciduenas, Lilian; Chao, Chih-kai; Thompson, Charles] Univ Montana, Ctr Struct & Funct Neurosci, Missoula, MT 59812 USA.
   [Calderon-Garciduenas, Lilian; Franco-Lira, Maricela] Cent Mil Hosp, Mexico City 11649, DF, Mexico.
   [D'Angiulli, Amedeo] Carleton Univ, Dept Neurosci, Ottawa, ON K1S 5B6, Canada.
   [Rodriguez-Diaz, Joel] Univ Valle Mexico, Escuela Ciencias Salud, Saltillo 25204, Coahuila, Mexico.
   [Blaurock-Busch, Eleonore; Busch, Yvette] Clin & Environm Lab Micro Trace Minerals MTM, D-91217 Hersbruck, Germany.
   [Mukherjee, Partha S.] Boise State Univ, Dept Math, Boise, ID 83725 USA.
   [Torres-Jardon, Ricardo] Univ Nacl Autonoma Mexico, Ctr Ciencias Atmosfera, Mexico City 04510, DF, Mexico.
   [Perry, George] Univ Texas San Antonio, Coll Sci, San Antonio, TX USA.
C3 University of Montana System; University of Montana; Carleton
   University; Universidade del Valle de Mexico; Boise State University;
   Universidad Nacional Autonoma de Mexico; University of Texas System;
   University of Texas at San Antonio (UTSA)
RP Calderón-Garcidueñas, L (corresponding author), Univ Montana, Ctr Struct & Funct Neurosci, 32 Campus Dr,Skaggs Bldg 287, Missoula, MT 59812 USA.
EM lilian.calderon-garciduenas@umontana.edu
RI Mukherjee, Partha/AAM-5466-2020; Chao, Chihkai/HGF-0244-2022;
   Torres-Jardon, Ricardo/W-7546-2018; Perry, George/A-8611-2009
OI Mukherjee, Partha Sarathi/0000-0003-1655-3534; Torres-Jardon,
   Ricardo/0000-0003-1874-6057; Perry, George/0000-0002-6547-0172
FU Semmes Foundation; Alzheimer's Association; NIH [G12-MD007591]
FX Support for Dr. George Perry was given by the Semmes Foundation,
   Alzheimer's Association and NIH G12-MD007591.
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NR 181
TC 93
Z9 99
U1 3
U2 109
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0013-9351
EI 1096-0953
J9 ENVIRON RES
JI Environ. Res.
PD JUL
PY 2015
VL 140
BP 579
EP 592
DI 10.1016/j.envres.2015.05.012
PG 14
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA CM7VH
UT WOS:000357904100067
PM 26037109
DA 2025-06-11
ER

PT J
AU Merz, CNB
   Johnson, BJ
   Kelsey, SF
   Reis, SE
   Lewis, JF
   Reichek, N
   Rogers, WJ
   Pepine, CF
   Shaw, LJ
AF Merz, CNB
   Johnson, BJ
   Kelsey, SF
   Reis, SE
   Lewis, JF
   Reichek, N
   Rogers, WJ
   Pepine, CF
   Shaw, LJ
CA WISE Study Grp
TI Diagnostic, prognostic, and cost assessment of coronary artery disease
   in women
SO AMERICAN JOURNAL OF MANAGED CARE
LA English
DT Article
ID TERM FOLLOW-UP; SYNDROME EVALUATION WISE; CHEST PAIN; SYNDROME-X;
   PATHOPHYSIOLOGICAL IMPLICATIONS; CLINICAL PRESENTATION; ANGINA-PECTORIS;
   EXERCISE TEST; FLOW RESERVE; ANGIOGRAMS
AB Women with obstructive coronary disease appear to be more challenging diagnostically and suffer a more adverse prognosis than men. More than one half of women with symptoms of ischemic heart disease have no obstructive coronary artery disease at coronary angiography, yet these women frequently have persistent symptom-related disability and consume large amounts of healthcare resources. Prior evidence has been limited regarding effective diagnostic strategies for the assessment of symptomatic women. The current report synthesizes existing evidence on diagnostic testing in women, including research from the ongoing National Heart, Lung, and Blood Institute-sponsored Women's Ischemia Syndrome Evaluation (WISE) study. In addition to recent published evidence (drawn from much larger cohorts of women) that stress echocardiography and nuclear imaging are similar in their ability to risk-stratify women, the WISE study is exploring new pathophysiological mechanisms of microvascular dysfunction in women. An unfolding body of evidence suggests that as tests become more diagnostically and prognostically accurate, the process will become more cost efficient. The results from a growing number of large observational series and National Institutes of Health-sponsored studies are expected to be the foundation for cost-effective diagnostic and prognostic strategies for the approximately 5 million women who undergo evaluation for coronary disease annually.
C1 Cedars Sinai Med Ctr, Cedars Sinai Res Inst, Dept Med, Div Cardiol, Los Angeles, CA 90048 USA.
   Univ Pittsburgh, Grad Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA 15260 USA.
   Univ Pittsburgh, Med Ctr, Cardiovasc Inst, Pittsburgh, PA 15260 USA.
   Univ Florida, Dept Med, Div Cardiol, Gainesville, FL 32611 USA.
   Allegheny Univ Hlth Sci, Dept Med, Div Cardiol, Pittsburgh, PA USA.
   Univ Alabama Birmingham, Dept Med, Div Cardiol, Birmingham, AL 35294 USA.
   Emory Univ, Rollins Sch Publ Hlth, Dept Hlth Policy & Management, Atlanta, GA 30322 USA.
C3 Cedars Sinai Medical Center; Pennsylvania Commonwealth System of Higher
   Education (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth
   System of Higher Education (PCSHE); University of Pittsburgh; State
   University System of Florida; University of Florida; University of
   Alabama System; University of Alabama Birmingham; Emory University;
   Rollins School Public Health
RP Cedars Sinai Med Ctr, Cedars Sinai Res Inst, Dept Med, Div Cardiol, 444 S San Vincente Blvd,Suite 901, Los Angeles, CA 90048 USA.
EM merz@cshs.org
RI Reis, Steven/J-3957-2014; Shaw, Leslee/ABG-4621-2022
OI Reis, Steven/0000-0001-8023-0102
FU NCRR NIH HHS [MO1-RR00425] Funding Source: Medline; NHLBI NIH HHS
   [N01-HV-68162, N01-HV-68164, N01-HV-68161, N01-HV-68163] Funding Source:
   Medline
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NR 53
TC 38
Z9 42
U1 0
U2 1
PU MANAGED CARE & HEALTHCARE COMMUNICATIONS LLC
PI PLAINSBORO
PA 666 PLAINSBORO RD, STE 300, PLAINSBORO, NJ 08536 USA
SN 1088-0224
J9 AM J MANAG CARE
JI Am. J. Manag. Care
PD OCT
PY 2001
VL 7
IS 10
BP 959
EP 965
PG 7
WC Health Care Sciences & Services; Health Policy & Services; Medicine,
   General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services; General & Internal Medicine
GA 483DC
UT WOS:000171617600002
PM 11669360
DA 2025-06-11
ER

PT J
AU He, Z
   Yang, PX
   Lin, QQ
   Thio, CHL
   Zhang, F
   Wang, RF
   Wang, Y
   Snieder, H
   Zhang, QY
AF He, Zhen
   Yang, Peixuan
   Lin, Qiuqiang
   Thio, Chris H. L.
   Zhang, Fan
   Wang, Ruifeng
   Wang, Yue
   Snieder, Harold
   Zhang, Qingying
TI Blood biomarkers for new-onset hypertension in midlife women: a nested
   case-control study
SO MENOPAUSE-THE JOURNAL OF THE MENOPAUSE SOCIETY
LA English
DT Article
DE Hemoglobin; New-onset hypertension; Platelet; Red blood cell; White
   blood cell
ID CHINESE ADULTS; NITRIC-OXIDE; CARDIOMETABOLIC RISK; OXIDATIVE STRESS;
   HEMOGLOBIN; PRESSURE; ASSOCIATION; PREVALENCE; INFLAMMATION; CELLS
AB ObjectiveMidlife in women is associated with an increase in prevalence of hypertension. Little is known on the risk factors of new-onset hypertension among middle-aged women.MethodsIn this nested case-control study, 1,430 women aged 40 to 60 years with repeated physical examinations between 2009 and 2019 were recruited. Data included age, body mass index, blood pressure (BP), and a series of blood biomarkers. Participants with hypertension were divided into two case-control samples: 388 cases with episodic new-onset hypertension (ie, one normal BP at the first visit and one abnormal BP during follow-up) each with two age-matched controls (n = 776) and 151 cases with regular new-onset hypertension (ie, normal BP at the first two visits and abnormal BP at two or more follow-up visits) each with three age-matched controls (n = 453). Multivariable-adjusted logistic regression was used to analyze the data.ResultsOur data showed very consistent results for episodic and regular new-onset hypertension, respectively, and verified known associations (odds ratio [95% confidence interval], per SD increase) with obesity (body mass index, 1.72 [1.49-1.98] and 1.81 [1.45-2.26]), inflammation (white blood cell count, 1.39 [1.23-1.58] and 1.38 [1.13-1.69]), and metabolic dysregulation (triglycerides, 1.25 [1.09-1.44] and 1.31 [1.08-1.58]; glucose, 1.46 [1.23-1.73] and 1.27 [1.05-1.54]) but, more surprisingly, also revealed positive associations with red blood cell count (1.27 [1.11-1.44] and 1.38 [1.14-1.68]), hemoglobin (1.18 [1.03-1.35] and 1.31 [1.05-1.64]), and platelet count (1.39 [1.20-1.61] and 1.33 [1.09-1.63]).ConclusionsIn addition to obesity and metabolic dysregulation, increased hemoglobin and counts of platelets, and red and white blood cells are associated with hypertension in this period. Future study may verify whether these associations are causal in nature and whether these variables are useful in risk stratification.
C1 [He, Zhen; Zhang, Fan; Wang, Yue; Zhang, Qingying] Shantou Univ, Dept Publ Hlth & Prevent Med, Med Coll, Shantou, Peoples R China.
   [He, Zhen; Thio, Chris H. L.; Zhang, Fan; Snieder, Harold] Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, Groningen, Netherlands.
   [Yang, Peixuan] Shantou Univ, Dept Phys Examinat, Affiliated Hosp 1, Med Coll, Shantou, Peoples R China.
   [Lin, Qiuqiang] Chenghai Peoples Hosp, Dept Internal Med, Shantou, Peoples R China.
   [Wang, Ruifeng] Chenghai Peoples Hosp, Dept Phys Examinat, Shantou, Peoples R China.
   [Zhang, Qingying] 22, Xinling Rd, Shantou 515041, Guangdong, Peoples R China.
   [Snieder, Harold] POB 30-001, NL-9700 RB Groningen, Netherlands.
C3 Shantou University; University of Groningen; Shantou University
RP Zhang, QY (corresponding author), 22, Xinling Rd, Shantou 515041, Guangdong, Peoples R China.; Snieder, H (corresponding author), POB 30-001, NL-9700 RB Groningen, Netherlands.
EM z.he@umcg.nl; doctorypx@126.com; linqiuqiangm@126.com;
   c.h.l.thio@umcg.nl; lemon_fan@163.com; 13502742792@163.com;
   610852383@qq.com; h.snieder@umcg.nl; qyzhang@stu.edu.cn
RI He, Zhen/JTT-4216-2023
OI Thio, Chris/0000-0003-2623-7172; He, Zhen/0000-0001-8901-8167
FU Natural Science Foundation of Guangdong Province [2021A1515011193]
FX This study was supported by the Natural Science Foundation of Guangdong
   Province (2021A1515011193).
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NR 46
TC 2
Z9 2
U1 5
U2 15
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1072-3714
EI 1530-0374
J9 MENOPAUSE
JI Menopause-J. Menopause Soc..
PD FEB
PY 2023
VL 30
IS 2
BP 156
EP 164
DI 10.1097/GME.0000000000002100
PG 9
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA 8J8JY
UT WOS:000922659000008
PM 36696640
DA 2025-06-11
ER

PT J
AU Feihl, F
   Liaudet, L
   Waeber, B
AF Feihl, Francois
   Liaudet, Lucas
   Waeber, Bernard
TI The macrocirculation and microcirculation of hypertension
SO CURRENT HYPERTENSION REPORTS
LA English
DT Article
ID ARTERY WALL MATERIAL; AGE-RELATED-CHANGES; CARDIAC SYNDROME-X; PULSE
   PRESSURE; BLOOD-PRESSURE; CAROTID-ARTERY; INDEPENDENT PREDICTOR; AORTIC
   STIFFNESS; ANTIHYPERTENSIVE TREATMENT; CARDIOVASCULAR EVENTS
AB Changes in vascular structure that accompany hypertension may contribute to hypertensive end-organ damage. Both the macrovascular and microvascular levels should be considered, as interactions between them are believed to be critically important. Regarding the macrocirculation, the article first reviews basic concepts of vascular biomechanics, such as arterial compliance, arterial distensibility, and stress-strain relationships of arterial wall material, and then reviews how hypertension affects the properties of conduit arteries, particularly examining evidence that it accelerates the progressive stiffening that normally occurs with advancing age. High arterial stiffness may increase central systolic and pulse pressure by two different mechanisms: 1) Abnormally high pulse wave velocity may cause pressure waves reflected in the periphery to reach the central aorta in systole, thus augmenting systolic pressure; 2) In the elderly, the interaction of the forward pressure wave with high arterial stiffness is mostly responsible for abnormally high pulse pressure. At the microvascular level, hypertensive disease is characterized by inward eutrophic or hypertrophic arteriolar remodeling and capillary rarefaction. These abnormalities may depend in part on the abnormal transmission of highly pulsatile blood pressure into microvascular networks, especially in highly perfused organs with low vascular resistance, such as the kidney, heart, and brain, where it contributes to hypertensive end-organ damage.
C1 [Waeber, Bernard] CHU Vaudois, Div Physiopathol Clin, CH-1011 Lausanne, Switzerland.
C3 University of Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV)
RP Waeber, B (corresponding author), CHU Vaudois, Div Physiopathol Clin, MP 14-204, CH-1011 Lausanne, Switzerland.
EM Bernard.Waeber@chuv.ch
RI Liaudet, Lucas/E-1322-2017
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NR 68
TC 106
Z9 115
U1 0
U2 11
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1522-6417
EI 1534-3111
J9 CURR HYPERTENS REP
JI Curr. Hypertens. Rep.
PD JUN
PY 2009
VL 11
IS 3
BP 182
EP 189
DI 10.1007/s11906-009-0033-6
PG 8
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 445VN
UT WOS:000266079700006
PM 19442327
DA 2025-06-11
ER

PT J
AU Kautzky-Willer, A
   Leutner, M
   Harreiter, J
AF Kautzky-Willer, Alexandra
   Leutner, Michael
   Harreiter, Jurgen
TI Sex differences in type 2 diabetes
SO DIABETOLOGIA
LA English
DT Review
DE Cardiovascular mortality; Gender; Macrovascular complications;
   Microvascular complications; Review; Risk factors; Sex; Therapy; Type 2
   diabetes
ID GENDER-DIFFERENCES; CARDIOVASCULAR-DISEASE; LIFE-STYLE; GLYCEMIC
   CONTROL; CORONARY ATHEROSCLEROSIS; JAPANESE PATIENTS; FASTING GLUCOSE;
   HEART-FAILURE; RISK-FACTORS; ALL-CAUSE
AB The prevalence of type 2 diabetes mellitus is increasing in both sexes, but men are usually diagnosed at a younger age and lower body fat mass than women. Worldwide, an estimated 17.7 million more men than women have diabetes mellitus. Women appear to bear a greater risk factor burden at the time of their type 2 diabetes diagnosis, especially obesity. Moreover, psychosocial stress might play a more prominent role in diabetes risk in women. Across their lifespan, women experience greater hormone fluctuations and body changes due to reproductive factors than men. Pregnancies can unmask pre-existing metabolic abnormalities, resulting in the diagnosis of gestational diabetes, which appears to be the most prominent risk factor for progression to type 2 diabetes in women. Additionally, menopause increases women's cardiometabolic risk profile. Due to the progressive rise in obesity, there is a global increase in women with pregestational type 2 diabetes, often with inadequate preconceptual care. There are differences between men and women regarding type 2 diabetes and other cardiovascular risk factors with respect to comorbidities, the manifestation of complications and the initiation of and adherence to therapy. Women with type 2 diabetes show greater relative risk of CVD and mortality than men. Moreover, young women with type 2 diabetes are currently less likely than men to receive the treatment and CVD risk reduction recommended by guidelines. Current medical recommendations do not provide information on sex-specific or gender-sensitive prevention strategies and management. Thus, more research on sex differences, including the underlying mechanisms, is necessary to increase the evidence in the future. Nonetheless, intensified efforts to screen for glucose metabolism disorders and other cardiovascular risk factors, as well as the early establishment of prophylactic measures and aggressive risk management strategies, are still required for both men and women at increased risk of type 2 diabetes. In this narrative review we aim to summarise sex-specific clinical features and differences between women and men with type 2 diabetes into risk factors, screening, diagnosis, complications and treatment.
C1 [Kautzky-Willer, Alexandra; Leutner, Michael; Harreiter, Jurgen] Med Univ Vienna, Dept Med 3, Div Endocrinol & Metab, Vienna, Austria.
   [Kautzky-Willer, Alexandra] Gender Inst, Lapura Womens Hlth Resort, Gars Am Kamp, Austria.
C3 Medical University of Vienna
RP Kautzky-Willer, A (corresponding author), Med Univ Vienna, Dept Med 3, Div Endocrinol & Metab, Vienna, Austria.; Kautzky-Willer, A (corresponding author), Gender Inst, Lapura Womens Hlth Resort, Gars Am Kamp, Austria.
EM alexandra.kautzky-willer@meduniwien.ac.at
OI Harreiter, Jurgen/0000-0003-2508-9403; Kautzky-Willer,
   Alexandra/0000-0002-3520-4105
FU Medical University of Vienna; GENDER-NET Plus ERA-NET Initiative
   [GNP-78]; Canadian Institutes of Health Research [GNP-161904]; La Caixa
   Foundation [LCF/PR/DE18/52010001]; Swedish Research Council
   [2018-00932]; Austrian Science Fund [FWF, I 4209]
FX Funding Open access funding provided by Medical University of Vienna.
   GOING-FWD funded by the GENDER-NET Plus ERA-NET Initiative (Project Ref.
   Number: GNP-78), the Canadian Institutes of Health Research
   (GNP-161904), La Caixa Foundation (LCF/PR/DE18/52010001), the Swedish
   Research Council (2018-00932) and the Austrian Science Fund (FWF, I
   4209).
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NR 138
TC 228
Z9 233
U1 23
U2 73
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0012-186X
EI 1432-0428
J9 DIABETOLOGIA
JI Diabetologia
PD JUN
PY 2023
VL 66
IS 6
BP 986
EP 1002
DI 10.1007/s00125-023-05891-x
EA MAR 2023
PG 17
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA I0XS0
UT WOS:000947275800002
PM 36897358
OA hybrid
HC Y
HP Y
DA 2025-06-11
ER

PT J
AU Maasen, K
   Eussen, SJPM
   Dagnelie, PC
   Houben, AJHM
   Webers, CAB
   Schram, MT
   Berendschot, TTJM
   Stehouwer, CDA
   Opperhuizen, A
   van Greevenbroek, MMJ
   Schalkwijk, CG
AF Maasen, Kim
   Eussen, Simone J. P. M.
   Dagnelie, Pieter C.
   Houben, Alfons J. H. M.
   Webers, Carroll A. B.
   Schram, Miranda T.
   Berendschot, Tos T. J. M.
   Stehouwer, Coen D. A.
   Opperhuizen, Antoon
   van Greevenbroek, Marleen M. J.
   Schalkwijk, Casper G.
TI Habitual intake of dietary methylglyoxal is associated with less
   low-grade inflammation: the Maastricht Study
SO AMERICAN JOURNAL OF CLINICAL NUTRITION
LA English
DT Article
DE diet; dicarbonyls; oxoaldehyde; methylglyoxal; glyoxal;
   3-deoxyglucosone; observational cohort; advanced glycation endproducts;
   inflammation; microcirculation
ID ENDOTHELIAL DYSFUNCTION; CARDIOVASCULAR-DISEASE; THERMAL HYPEREMIA;
   DICARBONYL STRESS; HYPERGLYCEMIA; IMPAIRMENT; GLYOXALASE; FOOD
AB Background Dicarbonyls are major reactive precursors of advanced glycation endproducts (AGEs). Dicarbonyls are formed endogenously and also during food processing. Circulating dicarbonyls and AGEs are associated with inflammation and microvascular complications of diabetes, but for dicarbonyls from the diet these associations are currently unknown. Objectives We sought to examine the associations of dietary dicarbonyl intake with low-grade inflammation and microvascular function. Methods In 2792 participants (mean +/- SD age: 60 +/- 8 y; 50% men; 26% type 2 diabetes) of the population-based cohort the Maastricht Study, we estimated the habitual intake of the dicarbonyls methylglyoxal (MGO), glyoxal (GO), and 3-deoxyglucosone (3-DG) by linking FFQ outcome data to our food composition database of the MGO, GO, and 3-DG content of >200 foods. Low-grade inflammation was assessed as six plasma biomarkers, which were compiled in a z score. Microvascular function was assessed as four plasma biomarkers, compiled in a zscore; as diameters and flicker light-induced dilation in retinal microvessels; as heat-induced skin hyperemic response; and as urinary albumin excretion. Cross-sectional associations of dietary dicarbonyls with low-grade inflammation and microvascular function were investigated using linear regression with adjustments for age, sex, potential confounders related to cardiometabolic risk factors, and lifestyle and dietary factors. Results Fully adjusted analyses revealed that higher intake of MGO was associated with a lower z score for inflammation [standardized beta coefficient (STD beta): -0.05; 95% CI: -0.09 to -0.01, with strongest inverse associations for hsCRP and TNF-alpha: both -0.05; -0.10 to -0.01]. In contrast, higher dietary MGO intake was associated with impaired retinal venular dilation after full adjustment (STD beta: -0.07; 95% CI: -0.12 to -0.01), but not with the other features of microvascular function. GO and 3-DG intakes were not consistently associated with any of the outcomes. Conclusion Higher habitual intake of MGO was associated with less low-grade inflammation. This novel, presumably beneficial, association is the first observation of an association between MGO intake and health outcomes in humans and warrants further investigation.
C1 [Maasen, Kim; Houben, Alfons J. H. M.; van Greevenbroek, Marleen M. J.; Schalkwijk, Casper G.] Maastricht Univ Med Ctr, CARIM Sch Cardiovasc Dis, Dept Internal Med, Maastricht, Netherlands.
   [Eussen, Simone J. P. M.; Dagnelie, Pieter C.] Maastricht Univ Med Ctr, CAPHRI Care & Publ Hlth Res Inst, CARIM Sch Cardiovasc Dis, Dept Epidemiol, Maastricht, Netherlands.
   [Webers, Carroll A. B.; Berendschot, Tos T. J. M.] Univ Eye Clin Maastricht, Maastricht Univ Med Ctr, Maastricht, Netherlands.
   [Schram, Miranda T.] Maastricht Univ Med Ctr, Heart & Vasc Ctr, Departmentof Internal Med, Maastricht, Netherlands.
   [Opperhuizen, Antoon] Maastricht Univ Med Ctr, NUTRIM Sch Nutr & Translat Res Metab, Dept Pharmacol & Toxicol, Maastricht, Netherlands.
   [Opperhuizen, Antoon] Netherlands Food & Consumer Prod Safety Author, Off Risk Assessment & Res, Utrecht, Netherlands.
C3 Maastricht University; Maastricht University Medical Centre (MUMC);
   Maastricht University; Maastricht University Medical Centre (MUMC);
   Maastricht University; Maastricht University Medical Centre (MUMC);
   Maastricht University; Maastricht University Medical Centre (MUMC);
   Maastricht University; Maastricht University Medical Centre (MUMC)
RP Schalkwijk, CG (corresponding author), Maastricht Univ Med Ctr, CARIM Sch Cardiovasc Dis, Dept Internal Med, Maastricht, Netherlands.
EM c.schalkwijk@maastrichtuniversity.nl
RI eussen, simone/JAC-5744-2023; Stehouwer, Coen/AAB-3435-2021;
   Berendschot, Tos TJM/M-8509-2016
OI Eussen, Simone/0000-0003-0559-6838; Berendschot, Tos
   TJM/0000-0002-8101-939X; Stehouwer, Coen/0000-0001-8752-3223; van
   Greevenbroek, Marleen/0000-0002-2989-1631; Schalkwijk, Casper
   G/0000-0003-0190-2690
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NR 49
TC 14
Z9 14
U1 0
U2 4
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0002-9165
EI 1938-3207
J9 AM J CLIN NUTR
JI Am. J. Clin. Nutr.
PD DEC 19
PY 2022
VL 116
IS 6
BP 1715
EP 1728
DI 10.1093/ajcn/nqac195
EA SEP 2022
PG 14
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 7Y7UV
UT WOS:000885667400001
PM 36055771
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Peterson, CM
   Beyl, RA
   Marlatt, KL
   Martin, CK
   Aryana, KJ
   Marco, ML
   Martin, RJ
   Keenan, MJ
   Ravussin, E
AF Peterson, Courtney M.
   Beyl, Robbie A.
   Marlatt, Kara L.
   Martin, Corby K.
   Aryana, Kayanush J.
   Marco, Maria L.
   Martin, Roy J.
   Keenan, Michael J.
   Ravussin, Eric
TI Effect of 12 wk of resistant starch supplementation on cardiometabolic
   risk factors in adults with prediabetes: a randomized controlled trial
SO AMERICAN JOURNAL OF CLINICAL NUTRITION
LA English
DT Article
DE prediabetes; resistant starch; glycemic control; intravenous glucose
   tolerance test; respiratory chamber; ectopic fat; energy expenditure;
   fat oxidation
ID NATIVE BANANA STARCH; INSULIN SENSITIVITY; POSTPRANDIAL INSULIN;
   ENERGY-EXPENDITURE; OXIDATIVE STRESS; ADIPOSE-TISSUE; WOMEN; GLUCOSE;
   OBESE; CONSUMPTION
AB Background: Type 2 resistant starch (RS2) has been shown to improve glycemic control and some cardiovascular endpoints in rodent and human studies.
   Objective: The aim of this study was to perform one of the first randomized clinical trials in adults with prediabetes and one of the longest trials to test whether RS2 can improve cardiometabolic health.
   Design: 68 overweight [body mass index (BMI) >= 27 kg/m(2)] adults aged 35-75 y with prediabetes were randomized to consume 45 g/d of high-amylose maize (RS2) or an isocaloric amount of the rapidly digestible starch amylopectin (control) for 12 wk. At baseline and postintervention, ectopic fat depots (visceral adipose tissue, intrahepatic lipids, and intramyocellular lipids) were measured by magnetic resonance imaging/spectroscopy, energy metabolism by respiratory chamber, and carbohydrate metabolism by glycated hemoglobin (HbA1c), an intravenous glucose tolerance test, and a meal tolerance test. Cardiovascular risk factors-serum lipids, blood pressure, heart rate, and inflammatory markers (high-sensitivity C-reactive protein [hs-CRP], interleukin-6, and tumor necrosis factor [TNF]-alpha)-werealso measured. The primary endpoints were insulin sensitivity, insulin secretion, ectopic fat, and markers of inflammation. Data were primarily analyzed as treatment effects via a linear mixed model both with and without the addition of covariates.
   Results: Relative to the control group, RS2 lowered HbA1c by a clinically insignificant 0.1 +/- 0.2% (Delta = -1 +/- 2 mmol/mol; P = 0.05) but did not affect insulin secretion, insulin sensitivity, the disposition index, or glucose or insulin areas under the curve relative to baseline (P >= 0.23). RS2 decreased heart rate by 5 +/- 9 beats/min (P = 0.02) and TNF-alpha concentrations by 2.1 +/- 2.7 pg/mL (P = 0.004), relative to the control group. Ectopic fat, energy expenditure, substrate oxidation, and all other cardiovascular risk factors were unaffected (P >= 0.06).
   Conclusions: 12 wk of supplementationwith resistant starch reduced the inflammatory marker TNF-alpha and heart rate, but it did not significantly improve glycemic control and other cardiovascular disease risk factors, in adults with prediabetes.
C1 [Peterson, Courtney M.; Marlatt, Kara L.; Martin, Corby K.; Martin, Roy J.; Ravussin, Eric] Pennington Biomed Res Ctr, Div Clin Sci, 6400 Perkins Rd, Baton Rouge, LA 70808 USA.
   [Beyl, Robbie A.] Pennington Biomed Res Ctr, Biostat, 6400 Perkins Rd, Baton Rouge, LA 70808 USA.
   [Peterson, Courtney M.] Univ Alabama Birmingham, Dept Nutr Sci, Birmingham, AL 35294 USA.
   [Aryana, Kayanush J.] Louisiana State Univ, Ctr Agr, Sch Anim Sci, Baton Rouge, LA 70803 USA.
   [Marco, Maria L.] Univ Calif Davis, Food Sci & Technol, Davis, CA 95616 USA.
   [Martin, Roy J.; Keenan, Michael J.] Louisiana State Univ, Sch Nutr & Food Sci, Baton Rouge, LA 70803 USA.
C3 Louisiana State University System; Louisiana State University;
   Pennington Biomedical Research Center; Louisiana State University
   System; Louisiana State University; Pennington Biomedical Research
   Center; University of Alabama System; University of Alabama Birmingham;
   Louisiana State University System; Louisiana State University;
   University of California System; University of California Davis;
   Louisiana State University System; Louisiana State University
RP Ravussin, E (corresponding author), Pennington Biomed Res Ctr, Div Clin Sci, 6400 Perkins Rd, Baton Rouge, LA 70808 USA.
EM eric.ravussin@pbrc.edu
RI Beyl, Robbie/N-1951-2017; Ravussin, Eric/N-1985-2017; Marco,
   Maria/H-2322-2014; Martin, Corby/N-1976-2017; Keenan,
   Mickey/LDF-7681-2024
OI Ravussin, Eric/0000-0003-2129-547X
FU National Institute of Diabetes and Digestive and Kidney Diseases
   [R01DK092575]; National Center for Advancing Translational Sciences
   career development grant [KL2TR001419]; Nutrition Obesity Research
   Center (NORC) [P30DK072476]; Louisiana Clinical and Translational
   Science Center (LA CaTS) [U54GM104940]
FX Supported by National Institute of Diabetes and Digestive and Kidney
   Diseases grant R01DK092575 (to ER). This work was also supported by
   National Center for Advancing Translational Sciences career development
   grant KL2TR001419 (to CMP); by Nutrition Obesity Research Center (NORC)
   grant P30DK072476; and by Louisiana Clinical and Translational Science
   Center (LA CaTS) grant U54GM104940.
CR [Anonymous], 2017, National Diabetes Statistics Report
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NR 40
TC 60
Z9 65
U1 2
U2 26
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0002-9165
EI 1938-3207
J9 AM J CLIN NUTR
JI Am. J. Clin. Nutr.
PD SEP
PY 2018
VL 108
IS 3
BP 492
EP 501
DI 10.1093/ajcn/nqy121
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA GT3NN
UT WOS:000444410100010
PM 30010698
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Ross, MD
   Malone, EM
   Simpson, R
   Cranston, I
   Ingram, L
   Wright, GP
   Chambers, G
   Florida-James, G
AF Ross, Mark D.
   Malone, Eva M.
   Simpson, Richard
   Cranston, Islay
   Ingram, Lesley
   Wright, Graham P.
   Chambers, George
   Florida-James, Geraint
TI Lower resting and exercise-induced circulating angiogenic progenitors
   and angiogenic T cells in older men
SO AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
LA English
DT Article
DE age; angiogenesis; exercise; fitness; progenitor cells; T cells
ID CORONARY-ARTERY-DISEASE; CHRONIC HEART-FAILURE; OXIDATIVE STRESS;
   VASCULAR-DISEASE; CROSS-VALIDATION; HEALTHY-MEN; AGE; INCREASES;
   CAPACITY; DYSFUNCTION
AB Aging is associated with a dysfunctional endothelial phenotype as well as reduced angiogenic capabilities. Exercise exerts beneficial effects on the cardiovascular system, possibly by increasing/maintaining the number and/or function of circulating angiogenic cells (CACs), which are known to decline with age. However, the relationship between cardiorespiratory fitness (CRF) and age-related changes in the frequency of CACs, as well as the exercise-induced responsiveness of CACs in older individuals, has not yet been determined. One-hundred seven healthy male volunteers, aged 18-75 yr, participated in study 1. CRF was estimated using a submaximal cycling ergometer test. Circulating endothelial progenitor cells (EPCs), angiogenic T cells (T-ANG), and their chemokine (C-X-C motif) receptor 4 (CXCR4) cell surface receptor expression were enumerated by flow cytometry using peripheral blood samples obtained under resting conditions before the exercise test. In study 2, 17 healthy men (8 young men, 18-25 yr; 9 older men, 60-75 yr) were recruited, and these participants undertook a 30-min cycling exercise bout at 70% maximal O-2 consumption, with CACs enumerated before and immediately after exercise. Age was inversely associated with both CD34(+) progenitor cells (r(2) = -0.140, P = 0.000) and TANG (r(2) = -0.176, P = 0.000) cells as well as CXCR4-expressing CACs (CD34(+) : r(2) = -0.167, P = 0.000; EPCs: r(2) = -0.098, P = 0.001; T-ANG: r(2) = -0.053, P = 0.015). However, after correcting for age, CRF had no relationship with either CAC subset. In addition, older individuals displayed attenuated exercise-induced increases in CD34(+) progenitor cells, T-ANG, CD4(+), T-ANG, and CD8(+)CXCR4(+) T-ANG cells. Older men display lower CAC levels, which may contribute to increased risk of cardiovascular disease, and older adults display an impaired exercise-induced responsiveness of these cells.
   NEW & NOTEWORTHY Older adults display lower circulating progenitor cell and angiogenic T cell counts compared with younger individuals independently of cardiometabolic risk factors and cardiorespiratory fitness. Older adults also display impaired exercise-induced mobilization of these vasculogenic cells.
C1 [Ross, Mark D.; Malone, Eva M.; Cranston, Islay; Ingram, Lesley; Wright, Graham P.; Chambers, George; Florida-James, Geraint] Edinburgh Napier Univ, Sch Appl Sci, Edinburgh EH11 4BN, Midlothian, Scotland.
   [Simpson, Richard] Univ Arizona, Coll Agr & Life Sci, Dept Nutr Sci, Tucson, AZ USA.
   [Simpson, Richard] Univ Arizona, Coll Med, Dept Pediat, Tucson, AZ USA.
C3 Edinburgh Napier University; University of Arizona; University of
   Arizona
RP Ross, MD (corresponding author), Edinburgh Napier Univ, Sch Appl Sci, Edinburgh EH11 4BN, Midlothian, Scotland.
EM M.Ross@napier.ac.uk
RI Simpson, Richard/H-4977-2011; Wright, George/M-1660-2017
OI Simpson, Richard/0000-0002-7064-6881; Florida-James,
   Geraint/0000-0001-7248-3476
FU Early Career Research Grant from Edinburgh Napier University
FX This study was partly funded by an Early Career Research Grant from
   Edinburgh Napier University, 2015-2016.
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NR 47
TC 32
Z9 32
U1 0
U2 6
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0363-6135
EI 1522-1539
J9 AM J PHYSIOL-HEART C
JI Am. J. Physiol.-Heart Circul. Physiol.
PD MAR
PY 2018
VL 314
IS 3
BP H392
EP H402
DI 10.1152/ajpheart.00592.2017
PG 11
WC Cardiac & Cardiovascular Systems; Physiology; Peripheral Vascular
   Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Physiology
GA GB1NX
UT WOS:000428818600002
PM 29167123
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Chen, YH
   Zheng, B
   Cheng, D
   He, YL
   Mo, ZC
AF Chen, Yu-Hua
   Zheng, Biao
   Cheng, Di
   He, Yu-Lin
   Mo, Zhong-Cheng
TI The Effect and Mechanism of Mitophagy on Insulin Resistance
SO PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS
LA English
DT Article
DE insulin resistance; mitophagy; cellular signaling molecules
ID MITOCHONDRIAL; DYSFUNCTION; AUTOPHAGY; INHIBITION; INCREASES; APOPTOSIS;
   RECEPTOR; COMPLEX; STRESS
AB Mitophagy, a highly precise form of autophagy, plays a pivotal role in maintaining cellular homeostasis by selectively targeting and eliminating damaged mitochondria through a process known as mitophagy. Within this tightly regulated mechanism, dysfunctional mitochondria are specifically delivered to lysosomes for degradation. Disruptions in mitophagy have been implicated in a diverse range of pathological conditions, spanning diseases of the nervous system, cardiovascular system, cancer, aging, and metabolic syndrome. The elucidation of mitophagy's impact on cardiovascular disorders, liver diseases, metabolic syndromes, immune dysfunctions, inflammatory conditions, and cancer has significantly advanced our understanding of the complex pathogenesis underlying these conditions. These studies have shed light on the intricate connections between dysfunctional mitophagy and disease progression. Among the disorders associated with mitochondrial dysfunction, insulin resistance (IR) stands out as a prominent condition linked to metabolic disorders. IR is characterized by a diminished response to normal levels of insulin, necessitating higher insulin levels to trigger a typical physiological reaction. Hyperinsulinemia and metabolic disturbances often coexist with IR, primarily due to defects in insulin signal transduction. Oxidative stress, stemming from mitochondrial dysfunction, exerts dual effects in the context of IR. Initially, it disrupts insulin signaling pathways and subtly contributes to the development of IR. Additionally, by inducing mitochondrial damage and autophagy, oxidative stress indirectly impedes insulin signaling pathways. Consequently, mitophagy acts as a protective mechanism, encapsulating damaged or dysfunctional mitochondria through the autophagy-lysosome pathway. This efficient process eliminates excessive oxidative stress reactive. The intricate interplay between mitochondrial function, oxidative stress, mitophagy, and IR represents a captivating field of investigation in the realm of metabolic disorders. By unraveling the underlying complexities and comprehending the intricate relationships between these intertwined processes, researchers strive toward uncovering novel therapeutic strategies. With a particular focus on mitochondrial quality control and the maintenance of redox homeostasis, these interventions hold tremendous potential in mitigating IR and enhancing overall metabolic health. Emerging evidence from a myriad of studies has shed light on the active involvement of mitophagy in the pathogenesis of metabolic disorders. Notably, interventions such as exercise, drug therapies, and natural products have been documented to induce mitophagy, thereby exerting beneficial effects on metabolic health through the activation of diverse signaling pathways. Several pivotal signaling molecules, including AMPK, PINK1/Parkin, BNIP3/Nix, and FUNDC1, have been identified as key regulators of mitophagy and have been implicated in the favorable outcomes observed in metabolic disorders. Of particular interest is the unique role of PINK1/Parkin in mitophagy compared to other proteins involved in this process. PINK1/Parkin exerts influence on mitophagy through the ubiquitination of outer mitochondrial membrane proteins. Conversely, BNIP3/Nix and FUNDC1 modulate mitophagy through their interaction with LC3, while also displaying certain interrelationships with each other.
   In this comprehensive review, our objective is to investigate the intricate interplay between mitophagy and IR, elucidating the relevant signaling pathways and exploring the treatment strategies that have garnered attention in recent years. By assimilating and integrating these findings, we aim to establish a comprehensive understanding of the multifaceted roles and intricate mechanisms by which mitophagy influences IR. This endeavor, in turn, seeks to provide novel insights and serve as a catalyst for further research in the pursuit of innovative treatments targeting IR.
C1 [Chen, Yu-Hua; Zheng, Biao; Cheng, Di; Mo, Zhong-Cheng] Guilin Med Univ, Inst Basic Med Sci, Dept Histol & Embryol, Guangxi Key Lab Diabetic Syst Med, Guilin 541199, Peoples R China.
   [Chen, Yu-Hua; Zheng, Biao; Cheng, Di; Mo, Zhong-Cheng] Guilin Med Univ, Joint Lab Chron Dis Prevent & Res, Guilin 422800, Hunan, Peoples R China.
   [Chen, Yu-Hua; Zheng, Biao; Cheng, Di; Mo, Zhong-Cheng] Hunan Mingshun Pharmaceut Ltd, Shaodong 422800, Peoples R China.
   [He, Yu-Lin] Guilin Med Univ, Basic Med Coll, Microbiol Dept, Guilin, Peoples R China.
C3 Guilin Medical University; Guilin Medical University; Guilin Medical
   University
RP Mo, ZC (corresponding author), Guilin Med Univ, Inst Basic Med Sci, Dept Histol & Embryol, Guangxi Key Lab Diabetic Syst Med, Guilin 541199, Peoples R China.; Mo, ZC (corresponding author), Guilin Med Univ, Joint Lab Chron Dis Prevent & Res, Guilin 422800, Hunan, Peoples R China.; Mo, ZC (corresponding author), Hunan Mingshun Pharmaceut Ltd, Shaodong 422800, Peoples R China.
EM 418497164@qq.com; zhchmo@hotmail.com
RI 莫, 中成/AAY-8561-2020; He, YU/JOZ-1548-2023
FU National Natural Science Foundation of China [82060091]; Horizontal
   Cooperation Project with Hunan Mingshun Pharmaceutical Co., Ltd.
   [2021GLHX01]
FX This work was supported by grants from The National Natural Science
   Foundation of China (82060091) and Horizontal Cooperation Project with
   Hunan Mingshun Pharmaceutical Co., Ltd. (2021GLHX01) .
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NR 106
TC 0
Z9 0
U1 4
U2 14
PU CHINESE ACAD SCIENCES, INST BIOPHYSICS
PI BEIJING
PA 15 DATUN RD, CHAOYAND DISTRICT, BEIJING, 100101, PEOPLES R CHINA
SN 1000-3282
J9 PROG BIOCHEM BIOPHYS
JI Prog. Biochem. Biophys.
PD APR
PY 2024
VL 51
IS 4
BP 772
EP 784
DI 10.16476/j.pibb.2023.0205
PG 13
WC Biochemistry & Molecular Biology; Biophysics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics
GA QP0S9
UT WOS:001221963600001
DA 2025-06-11
ER

PT J
AU Dempsey, PC
   Blankenship, JM
   Larsen, RN
   Sacre, JW
   Sethi, P
   Straznicky, NE
   Cohen, ND
   Cerin, E
   Lambert, GW
   Owen, N
   Kingwell, BA
   Dunstan, DW
AF Dempsey, Paddy C.
   Blankenship, Jennifer M.
   Larsen, Robyn N.
   Sacre, Julian W.
   Sethi, Parneet
   Straznicky, Nora E.
   Cohen, Neale D.
   Cerin, Ester
   Lambert, Gavin W.
   Owen, Neville
   Kingwell, Bronwyn A.
   Dunstan, David W.
TI Interrupting prolonged sitting in type 2 diabetes: nocturnal persistence
   of improved glycaemic control
SO DIABETOLOGIA
LA English
DT Article
DE Cardiometabolic risk; Diabetes; Glycaemic control; Glycaemic
   variability; Nocturnal glycaemia; Physical activity; Resistance
   exercise; Sedentary behaviour; Sitting; Walking
ID SEDENTARY TIME; OXIDATIVE STRESS; GLUCOSE; HYPERGLYCEMIA; EXERCISE;
   ADULTS; RISK; ASSOCIATION; CONTRACTION; VARIABILITY
AB Aims/hypothesis We aimed to examine the effect of interrupting 7 h prolonged sitting with brief bouts of walking or resistance activities on 22 h glucose homeostasis (including nocturnal-to-following morning hyperglycaemia) in adults with type 2 diabetes.
   Methods This study is an extension of a previously published randomised crossover trial, which included 24 inactive overweight/obese adults with type 2 diabetes (14 men; 62 +/- 6 years) who completed three 7 h laboratory conditions, separated by 6-14 day washout periods: SIT: (1) prolonged sitting (control); (2) light-intensity walking (LW): sitting plus 3 min bouts of light-intensity walking at 3.2 km/h every 30 min; (3) simple resistance activities (SRA): sitting plus 3 min bouts of simple resistance activities (alternating half-squats, calf raises, brief gluteal contractions and knee raises) every 30 min. In the present study, continuous glucose monitoring was performed for 22 h, encompassing the 7 h laboratory trial, the evening free-living period after leaving the laboratory and sleeping periods. Meals and meal times were standardised across conditions for all participants.
   Results Compared with SIT, both LW and SRA reduced 22 h glucose [ SIT: 11.6 +/- 0.3 mmol/l, LW: 8.9 +/- 0.3 mmol/l, SRA: 8.7 +/- 0.3 mmol/l; p< 0.001] and nocturnal mean glucose concentrations [ SIT: 10.6 +/- 0.4 mmol/l, LW: 8.1 +/- 0.4 mmol/l, SRA: 8.3 +/- 0.4 mmol/l; p< 0.001]. Furthermore, mean glucose concentrations were sustained nocturnally at a lower level until the morning following the intervention for both LW and SRA (waking glucose both - 2.7 +/- 0.4 mmol/l compared with SIT; p< 0.001).
   Conclusions/interpretation Interrupting 7 h prolonged sitting time with either LW or SRA reduced 22 h hyperglycaemia.The glycaemic improvements persisted after these laboratory conditions and nocturnally, until waking the following morning. These findings may have implications for adults with relatively well-controlled type 2 diabetes who engage in prolonged periods of sitting, for example, highly desk-bound workers.
C1 [Dempsey, Paddy C.; Larsen, Robyn N.; Sacre, Julian W.; Sethi, Parneet; Straznicky, Nora E.; Cohen, Neale D.; Cerin, Ester; Lambert, Gavin W.; Owen, Neville; Kingwell, Bronwyn A.; Dunstan, David W.] Baker IDI Heart & Diabet Inst, Level 4,99 Commercial Rd, Melbourne, Vic 3004, Australia.
   [Dempsey, Paddy C.; Lambert, Gavin W.; Owen, Neville; Kingwell, Bronwyn A.; Dunstan, David W.] Monash Univ, Cent Clin Sch, Fac Med, Nursing & Hlth Sci, Melbourne, Vic, Australia.
   [Blankenship, Jennifer M.] Univ Massachusetts, Dept Kinesiol, Amherst, MA USA.
   [Cerin, Ester] Univ Hong Kong, Sch Publ Hlth, Hong Kong, Hong Kong, Peoples R China.
   [Cerin, Ester] Australian Catholic Univ, Inst Hlth & Ageing, Melbourne, Vic, Australia.
   [Owen, Neville] Swinburne Univ Technol, Hlth Sci, Melbourne, Vic, Australia.
   [Owen, Neville] Univ Melbourne, Melbourne Sch Populat & Global Hlth, Melbourne, Vic, Australia.
   [Dunstan, David W.] Deakin Univ, Inst Phys Act & Nutr Res, Sch Exercise & Nutr Sci, Melbourne, Vic, Australia.
   [Dunstan, David W.] Australian Catholic Univ, Mary MacKillop Inst Hlth Res, Melbourne, Vic, Australia.
   [Dunstan, David W.] Univ Queensland, Sch Publ Hlth, Brisbane, Qld, Australia.
   [Dunstan, David W.] Univ Western Australia, Sch Sport Sci Exercise & Hlth, Perth, WA, Australia.
C3 Baker Heart and Diabetes Institute; Monash University; University of
   Massachusetts System; University of Massachusetts Amherst; University of
   Hong Kong; Australian Catholic University; Swinburne University of
   Technology; University of Melbourne; Deakin University; Australian
   Catholic University; University of Queensland; University of Western
   Australia
RP Dempsey, PC (corresponding author), Baker IDI Heart & Diabet Inst, Level 4,99 Commercial Rd, Melbourne, Vic 3004, Australia.; Dempsey, PC (corresponding author), Monash Univ, Cent Clin Sch, Fac Med, Nursing & Hlth Sci, Melbourne, Vic, Australia.
EM paddy.dempsey@bakeridi.edu.au
RI Dempsey, Paddy/LBH-0178-2024; Kingwell, Bronwyn/B-1183-2009; Owen,
   Neville/IXN-9070-2023; Larsen, Robyn/AAH-4137-2019; Lambert,
   Gavin/E-7384-2010; Sacre, Julian/AAQ-8261-2021; Dunstan,
   David/E-8473-2010; Straznicky, Nora/E-7484-2010; /L-1271-2015; Cohen,
   Neale/B-7595-2015
OI Kingwell, Bronwyn/0000-0002-2162-0458; /0000-0002-7599-165X; Lambert,
   Gavin/0000-0003-0315-645X; Sacre, Julian/0000-0003-1315-3463;
   Blankenship, Jennifer/0000-0002-8052-2516; Cohen,
   Neale/0000-0002-4441-9511; Larsen, Robyn/0000-0002-4985-7211; Dempsey,
   Paddy/0000-0002-1714-6087
FU NHMRC [1081734]; Victorian Government OIS scheme; Australian
   Postgraduate Award; Baker IDI Bright Sparks top up; NHMRC Fellowships
   scheme; ARC Future Fellowship [FT140100085]; MRC [MC_UU_12015/3] Funding
   Source: UKRI; National Health and Medical Research Council of Australia
   [1081734] Funding Source: NHMRC
FX This research was supported by a NHMRC project grant (no. 1081734) and
   the Victorian Government OIS scheme. PCD is supported by an Australian
   Postgraduate Award and a Baker IDI Bright Sparks top up scholarship.
   GWL, NO, BAK, JWS and DWD are supported by the NHMRC Fellowships scheme.
   EC is supported by an ARC Future Fellowship (no. FT140100085).
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NR 37
TC 76
Z9 86
U1 1
U2 19
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0012-186X
EI 1432-0428
J9 DIABETOLOGIA
JI Diabetologia
PD MAR
PY 2017
VL 60
IS 3
BP 499
EP 507
DI 10.1007/s00125-016-4169-z
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA EL2PO
UT WOS:000394462100015
PM 27942799
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Maredziak, M
   Bengs, S
   Portmann, A
   Haider, A
   Wijnen, WJ
   Warnock, G
   Etter, D
   Froehlich, S
   Fiechter, M
   Meisel, A
   Treyer, V
   Fuchs, TA
   Pazhenkottil, AP
   Buechel, RR
   Kaufmann, PA
   Gebhard, C
AF Maredziak, Monika
   Bengs, Susan
   Portmann, Angela
   Haider, Achi
   Wijnen, Winandus J.
   Warnock, Geoffrey, I
   Etter, Dominik
   Froehlich, Sandro
   Fiechter, Michael
   Meisel, Alexander
   Treyer, Valerie
   Fuchs, Tobias A.
   Pazhenkottil, Aju P.
   Buechel, Ronny R.
   Kaufmann, Philipp A.
   Gebhard, Catherine
TI Microvascular dysfunction and sympathetic hyperactivity in women with
   supra-normal left ventricular ejection fraction (snLVEF)
SO EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
LA English
DT Article
DE N-13-Ammonia PET; Supra-normal left ventricular ejection fraction;
   Coronary flow reserve; Sex and gender
ID MYOCARDIAL BLOOD-FLOW; HEART-RATE RESPONSE;
   POSITRON-EMISSION-TOMOGRAPHY; GENDER-DIFFERENCES; SYNDROME-X; ADENOSINE;
   AGE; N-13-AMMONIA; PET; REGADENOSON
AB Background Recently, a new disease phenotype characterized by supra-normal left ventricular ejection fraction (snLVEF) has been suggested, based on large datasets demonstrating an increased all-cause mortality in individuals with an LVEF > 65%. The underlying mechanisms of this association are currently unknown. Methods A total of 1367 patients (352 women, mean age 63.1 +/- 11.6 years) underwent clinically indicated rest/adenosine stress ECG-gated N-13-ammonia positron emission tomography (PET) between 1995 and 2017 at our institution. All patients were categorized according to LVEF. A subcohort of 698 patients (150 women) were followed for major adverse cardiac events (MACEs), a composite of cardiac death, non-fatal myocardial infarction, cardiac-related hospitalization, and revascularization. Results The prevalence of a snLVEF (>= 65%) was higher in women as compared to that in men (31.3% vs 18.8%, p < 0.001). In women, a significant reduction in coronary flow reserve (CFR, p < 0.001 vs normal LVEF) and a blunted heart rate reserve (% HRR, p = 0.004 vs normal LVEF) during pharmacological stress testing-a surrogate marker for autonomic dysregulation-were associated with snLVEF. Accordingly, reduced CFR and HRR were identified as strong and independent predictors for snLVEF in women in a fully adjusted multinomial regression analysis. After a median follow-up time of 5.6 years, women with snLVEF experienced more often a MACE than women with normal (55-65%) LVEF (log rank p < 0.001), while such correlation was absent in men (log rank p = 0.76). Conclusion snLVEF is associated with an increased risk of MACE in women, but not in men. Microvascular dysfunction and an increased sympathetic tone in women may account for this association.
C1 [Maredziak, Monika; Bengs, Susan; Portmann, Angela; Haider, Achi; Wijnen, Winandus J.; Warnock, Geoffrey, I; Etter, Dominik; Froehlich, Sandro; Fiechter, Michael; Meisel, Alexander; Treyer, Valerie; Fuchs, Tobias A.; Pazhenkottil, Aju P.; Buechel, Ronny R.; Kaufmann, Philipp A.; Gebhard, Catherine] Univ Hosp Zurich, Dept Nucl Med, Raemistr 100, CH-8091 Zurich, Switzerland.
   [Maredziak, Monika; Bengs, Susan; Portmann, Angela; Haider, Achi; Wijnen, Winandus J.; Warnock, Geoffrey, I; Etter, Dominik; Froehlich, Sandro; Fiechter, Michael; Gebhard, Catherine] Univ Zurich, Ctr Mol Cardiol, Zurich, Switzerland.
C3 University of Zurich; University Zurich Hospital; University of Zurich
RP Gebhard, C (corresponding author), Univ Zurich, Ctr Mol Cardiol, Zurich, Switzerland.
EM Catherine.gebhard@usz.ch
RI Haider, Ahmed/AAQ-6443-2020; Gebhard, Catherine/AAT-7060-2020; Fuchs,
   Tobias/N-4435-2013; Treyer, Valerie/G-6986-2018; Haider,
   Achi/N-3834-2017
OI Kaufmann, Philipp Antonio/0000-0002-9451-5210; Treyer,
   Valerie/0000-0002-4584-3031; Haider, Achi/0000-0002-5204-4473; Buechel,
   Ronny Ralf/0000-0001-8064-8904; Portmann, Angela/0000-0002-0973-5439;
   Bengs, Susan/0000-0003-2424-3894; Pazhenkottil, Aju/0000-0002-8847-2154
FU Swiss National Science Foundation (SNSF); Olga Mayenfisch Foundation,
   Switzerland; OPO Foundation, Switzerland; Novartis Foundation,
   Switzerland; Swiss Heart Foundation; Helmut Horten Foundation,
   Switzerland; EMDO Foundation, Switzerland; Iten-Kohaut Foundation,
   Switzerland; University Hospital Zurich Foundation; University of Zurich
   (UZH) Foundation
FX CG was supported by grants from the Swiss National Science Foundation
   (SNSF); the Olga Mayenfisch Foundation, Switzerland; the OPO Foundation,
   Switzerland; the Novartis Foundation, Switzerland; the Swiss Heart
   Foundation; the Helmut Horten Foundation, Switzerland; the EMDO
   Foundation, Switzerland; the Iten-Kohaut Foundation, Switzerland; and
   the University Hospital Zurich Foundation. SB was supported by the
   University of Zurich (UZH) Foundation.
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NR 48
TC 32
Z9 35
U1 3
U2 3
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1619-7070
EI 1619-7089
J9 EUR J NUCL MED MOL I
JI Eur. J. Nucl. Med. Mol. Imaging
PD DEC
PY 2020
VL 47
IS 13
BP 3094
EP 3106
DI 10.1007/s00259-020-04892-x
EA JUN 2020
PG 13
WC Radiology, Nuclear Medicine & Medical Imaging
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Radiology, Nuclear Medicine & Medical Imaging
GA PD0UZ
UT WOS:000538380200001
PM 32506162
DA 2025-06-11
ER

PT J
AU Hillier, E
   Covone, J
   Friedrich, MG
AF Hillier, Elizabeth
   Covone, Jason
   Friedrich, Matthias G.
TI Oxygenation-sensitive Cardiac MRI with Vasoactive Breathing Maneuvers
   for the Non-invasive Assessment of Coronary Microvascular Dysfunction
SO JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
LA English
DT Article
ID REGIONAL MYOCARDIAL OXYGENATION; ARTERY-DISEASE INSIGHTS; ENDOTHELIAL
   DYSFUNCTION; MAGNETIC-RESONANCE; SYNDROME-X; HEART; ADENOSINE;
   PERFUSION; STRESS; STATE
AB Oxygenation-sensitive cardiac magnetic resonance imaging (OS-CMR) is a diagnostic technique that uses the inherent paramagnetic properties of deoxyhemoglobin as an endogenous source of tissue contrast. Used in combination with standardized vasoactive breathing maneuvers (hyperventilation and apnea) as a potent nonpharmacologic vasomotor stimulus, OS-CMR can monitor changes in myocardial oxygenation. Quantifying such changes during the cardiac cycle and throughout vasoactive maneuvers can provide markers for coronary macro- and microvascular function and thereby circumvent the need for any extrinsic, intravenous contrast or pharmacologic stress agents.
   OS-CMR uses the well-known sensitivity of T2*-weighted images to blood oxygenation. Oxygenation-sensitive images can be acquired on any cardiac MRI scanner using a modified standard clinical steady-state free precession (SSFP) cine sequence, making this technique vendor-agnostic and easily implemented. As a vasoactive breathing maneuver, we apply a 4 min breathing protocol of 120 s of free breathing, 60 s of paced hyperventilation, followed by an expiratory breath-hold of at least 30 s. The regional and global response of myocardial tissue oxygenation to this maneuver can be assessed by tracking the signal intensity change. The change over the initial 30 s of the post-hyperventilation breath-hold, referred to as the breathinginduced myocardial oxygenation reserve (B-MORE) has been studied in healthy people and various pathologies. A detailed protocol for performing oxygen-sensitive CMR scans with vasoactive maneuvers is provided.
   As demonstrated in patients with microvascular dysfunction in yet incompletely understood conditions, such as inducible ischemia with no obstructive coronary artery stenosis (INOCA), heart failure with preserved ejection fraction (HFpEF), or microvascular dysfunction after heart transplantation, this approach provides unique, clinically important, and complementary information on coronary vascular function.
C1 [Hillier, Elizabeth; Covone, Jason; Friedrich, Matthias G.] McGill Univ, Fac Med & Hlth Sci, Montreal, PQ, Canada.
   [Hillier, Elizabeth] Univ Alberta, Faulty Med & Dent, Edmonton, AB, Canada.
   [Friedrich, Matthias G.] McGill Univ, Dept Med, Montreal, PQ, Canada.
   [Friedrich, Matthias G.] McGill Univ, Dept Diagnost Radiol, Montreal, PQ, Canada.
C3 McGill University; University of Alberta; McGill University; McGill
   University
RP Friedrich, MG (corresponding author), McGill Univ, Fac Med & Hlth Sci, Montreal, PQ, Canada.; Friedrich, MG (corresponding author), McGill Univ, Dept Med, Montreal, PQ, Canada.; Friedrich, MG (corresponding author), McGill Univ, Dept Diagnost Radiol, Montreal, PQ, Canada.
EM matthias.friedrich@mcgill.ca
RI Friedrich, Matthias/H-8474-2015
OI Friedrich, Matthias/0000-0003-1204-5647
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NR 53
TC 7
Z9 7
U1 0
U2 5
PU JOURNAL OF VISUALIZED EXPERIMENTS
PI CAMBRIDGE
PA 1 ALEWIFE CENTER, STE 200, CAMBRIDGE, MA 02140 USA
SN 1940-087X
J9 JOVE-J VIS EXP
JI J. Vis. Exp.
PD AUG
PY 2022
IS 186
DI 10.3791/64149
PG 20
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 8R4OE
UT WOS:000927873000056
PM 36062996
DA 2025-06-11
ER

PT J
AU Yilmaz, A
   Athanasiadis, A
   Mahrholdt, H
   Voehringer, M
   Ong, P
   Hill, S
   Kispert, EM
   Seebo, M
   Sechtem, U
AF Yilmaz, Ali
   Athanasiadis, Anastasios
   Mahrholdt, Heiko
   Voehringer, Matthias
   Ong, Peter
   Hill, Stefan
   Kispert, Eva-Maria
   Seebo, Melanie
   Sechtem, Udo
TI Diagnostic value of perfusion cardiovascular magnetic resonance in
   patients with angina pectoris but normal coronary angiograms assessed by
   intracoronary acetylcholine testing
SO HEART
LA English
DT Article
ID ASSOCIATION TASK-FORCE; CARDIAC SYNDROME-X; ARTERY-DISEASE; CHEST-PAIN;
   HYPERTENSIVE PATIENTS; MYOCARDIAL-ISCHEMIA; AMERICAN-COLLEGE; FLOW
   RESERVE; ECHOCARDIOGRAPHY; DYSFUNCTION
AB Background Perfusion cardiovascular magnetic resonance (CMR) has a high sensitivity for the detection of significant coronary artery disease (CAD). However, the specificity of this method is lower than its sensitivity. The reason for this observation is hitherto unclear and has been either explained by 'false-positive' results or by microvascular dysfunction in patients without CAD.
   Objective To evaluate whether pathological myocardial perfusion-CMR imaging in symptomatic patients without significant CAD is associated with coronary epicardial or microvascular dysfunction.
   Methods In this retrospective study, 42 patients who presented with unstable angina pectoris underwent (a) an adenosine-stress perfusion-CMR study; (b) coronary angiography; (c) intracoronary acetylcholine (ACh) testing following coronary angiography with exclusion of significant CAD. The CMR protocol comprised cine imaging followed by adenosine first-pass perfusion imaging and late gadolinium enhancement-CMR. Diagnostic left ventriculography and multiplane coronary angiography were performed before intracoronary ACh testing.
   Results An adenosine-induced, reversible subendocardial perfusion defect was detected in 22/42 patients (52%) without significant CAD. Coronary epicardial vasospasm was detected in 10/42 patients (24%) while microvascular dysfunction was found in 20/42 patients (48%). Patients with a reversible stress-induced perfusion defect had significantly more often a pathological coronary epicardial or microvascular vasoreaction (20/22; 91%) during intracoronary ACh testing than those without a perfusion defect (10/20; 50%; p<0.01). Univariate correlation analyses revealed a substantial association between a pathological ACh-testing result and a perfusion defect in the antecedent CMR study (r= +0.45; p<0.01).
   Conclusions Reversible perfusion defects depicted by perfusion-CMR in patients without significant CAD are mostly due to coronary epicardial or microvascular dysfunction, and correct interpretation of such perfusion-CMR results may enable targeted treatment.
C1 [Yilmaz, Ali; Athanasiadis, Anastasios; Mahrholdt, Heiko; Voehringer, Matthias; Ong, Peter; Hill, Stefan; Kispert, Eva-Maria; Seebo, Melanie; Sechtem, Udo] Robert Bosch Krankenhaus, Div Cardiol, D-70376 Stuttgart, Germany.
C3 Bosch; Robert Bosch Krankenhaus
RP Yilmaz, A (corresponding author), Robert Bosch Krankenhaus, Div Cardiol, Auerbachstr 110, D-70376 Stuttgart, Germany.
EM ali.yilmaz@rbk.de
RI Sechtem, Udo/ADK-6380-2022; Yılmaz, Ali/KLZ-9798-2024
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NR 37
TC 22
Z9 22
U1 0
U2 0
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 1355-6037
EI 1468-201X
J9 HEART
JI Heart
PD MAR
PY 2010
VL 96
IS 5
BP 372
EP 379
DI 10.1136/hrt.2009.174367
PG 8
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 563KB
UT WOS:000275127000011
PM 19934103
DA 2025-06-11
ER

PT J
AU Fujii, H
   Taktuchi, S
   Kamide, K
   Horio, T
   Niizuma, S
   Tanaka, N
   Hashimoto, S
   Nakatani, S
   Fukagawa, M
   Kawano, Y
AF Fujii, H
   Taktuchi, S
   Kamide, K
   Horio, T
   Niizuma, S
   Tanaka, N
   Hashimoto, S
   Nakatani, S
   Fukagawa, M
   Kawano, Y
TI Clinical implications of assessing coronary flow velocity reserve and
   plasma endothelin-1 in hypertensive patients
SO HYPERTENSION RESEARCH
LA English
DT Article
DE coronary flow velocity reserve; endothelin-1; endothelial function;
   hypertension; coronary artery disease
ID ANGINA-PECTORIS; DOPPLER-ECHOCARDIOGRAPHY; NONINVASIVE ASSESSMENT;
   ARTERY-STENOSIS; CHEST-PAIN; SYNDROME-X; IMPAIRMENT; MECHANISMS;
   RESISTANCE; ISCHEMIA
AB Previous reports have indicated that hypertensive patients who have angina-like chest pain and normal coronary arteriograms have reduced coronary flow velocity reserve (CFVR) levels. In addition, elevated plasma endothelin-1 (ET-1) levels have been reported to be associated with microvascular angina. The purpose of this study was to evaluate the plasma ET-1 levels and CFVR in patients with chest pain but without coronary artery disease (CAD). A total of 66 patients were included in this study. CAD was ruled out by exercise stress test or coronary angiogram. Plasma ET-1 and CFVR measurements were performed in patients with (n=35) and without (n=31) a history of angina-like chest pain. CFVR was measured using adenosine-triphosphate stress transthoracic Doppler echocardiography. The mean ET-1 level was significantly higher and the CFVR was significantly lower in patients in the symptomatic group than in those in the asymptomatic group (ET-1: 3.85 +/- 1.24 pg/ml vs. 2.98 +/- 1.27 pg/ml, CFVR: 2.26 +/- 0.48 vs. 2.77 +/- 0.11, respectively). Plasma ET-1 level and CFVR were significantly correlated with each other (-r=0.265, p=0.033). Age, blood pressure, cardiovascular risk factors, and left ventricular mass index were similar between the two groups. The results of multiple regression analysis indicate that age (p=0.008) and plasma ET-1 concentration (p=0.031) had statistically independent associations with CFVR. Attenuated CFVR in the symptomatic hypertensive patients was associated with endothelial dysfunction, which results in elevated plasma ET-1 levels. The link between these two parameters may play a role in the genesis of chest pain in hypertensive patients without CAD.
C1 Kobe Univ, Grad Sch Med, Dept Clin Mol Med, Div Diabet Digest & Kidney Dis,Chuo Ku, Kobe, Hyogo 6500017, Japan.
   Natl Cardiovasc Ctr, Div Hypertens & Nephrol, Suita, Osaka 565, Japan.
   Natl Cardiovasc Ctr, Testing Div, Lab Clin Physiol, Suita, Osaka 565, Japan.
   Natl Cardiovasc Ctr, Div Cardiol, Suita, Osaka 565, Japan.
C3 Kobe University; National Cerebral & Cardiovascular Center - Japan;
   National Cerebral & Cardiovascular Center - Japan; National Cerebral &
   Cardiovascular Center - Japan
RP Kobe Univ, Grad Sch Med, Dept Clin Mol Med, Div Diabet Digest & Kidney Dis,Chuo Ku, 7-5-2 Kusunoki Cho, Kobe, Hyogo 6500017, Japan.
EM hideki-f@tg7.so-net.ne.jp
RI Kawano, Yuhei/AAM-2251-2020; Fujii, Hideki/AAF-6610-2020
OI Fujii, Hideki/0000-0001-7610-1068; Fukagawa,
   Masafumi/0000-0002-7832-2339
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NR 32
TC 10
Z9 10
U1 0
U2 0
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0916-9636
EI 1348-4214
J9 HYPERTENS RES
JI Hypertens. Res.
PD NOV
PY 2005
VL 28
IS 11
BP 911
EP 916
DI 10.1291/hypres.28.911
PG 6
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 013SG
UT WOS:000235429100008
PM 16555580
OA Bronze
DA 2025-06-11
ER

PT J
AU Hens, W
   Vissers, D
   Annemans, L
   Gielen, J
   Van Gaal, L
   Taeymans, J
   Verhaeghe, N
AF Hens, W.
   Vissers, D.
   Annemans, L.
   Gielen, J.
   Van Gaal, L.
   Taeymans, J.
   Verhaeghe, N.
TI Health-related costs in a sample of premenopausal non-diabetic
   overweight or obese females in Antwerp region: a cost-of-illness
   analysis
SO ARCHIVES OF PUBLIC HEALTH
LA English
DT Article
DE Cost-of-illness analysis; Overweight; Obesity; Public health
ID CARE COSTS; RISK; LIFE; DEPRESSION; BURDEN; DIARY
AB Background: People with overweight or obesity are at increased risk for disease later in life which cause important health costs. The aim of this study was to estimate the health status and the corresponding costs in a sample of females with overweight or obesity which were participating in a Randomized Controlled Trial (RCT) exploring the effect of lifestyle habits changes on ectopic adipose tissue.
   Methods: Sixty-two non-diabetic premenopausal females without major comorbidities of overweight and obesity were recruited among patients visiting endocrinologists at the obesity clinic of the University Hospital of Antwerp and the University of Antwerp. A RCT-embedded cost-of-illness approach with societal perspective, based on self-reported questionnaires and cost diaries (3 months recall) was applied to estimate the prevalence of different comorbidities and the related direct and indirect costs in this sample of overweight or obese females. The European Quality-of-Life-5D questionnaire was used to define the health state and the corresponding utility index of the participants.
   Results: The average direct health costs and health utilities observed in this sample were comparable with the general Flemish female population. This may partially be explained by the strict inclusion criteria of the RCT (i.e. overweight or obesity without diabetes type 2 or cardiovascular diseases). However, 15% of the participants had five or more comorbidities resulting in higher average costs and lower average health utility as compared to the general population, only 3 participants were diagnozed with the metabolic syndrome. In this subsample productivity was low due to high average absenteeism, yielding important total costs for the society.
   Conclusion: Secondary prevention to avoid health deterioration in overweight or obese females without major comorbidies is needed to contain health care costs.
   Trial registration: ClinicalTrials.gov: NCT02831621, approval of the ethics committee of the University Hospital of Antwerp (number: 14/17/205 -ref: 7543075363).
C1 [Hens, W.; Vissers, D.] Univ Antwerp, Fac Med & Hlth Sci, Antwerp, Belgium.
   [Annemans, L.; Verhaeghe, N.] Univ Ghent, Fac Med & Hlth Sci, Ghent, Belgium.
   [Gielen, J.] Antwerp Univ Hosp, Dept Radiol, Antwerp, Belgium.
   [Van Gaal, L.] Antwerp Univ Hosp, Dept Endocrinol, Diabetol & Metab, Antwerp, Belgium.
   [Taeymans, J.] Bern Univ Appl Sci Hlth, Bern, Switzerland.
   [Taeymans, J.] Vrije Univ Brussel, Fac Sport & Rehabil Sci, Brussels, Belgium.
C3 University of Antwerp; Ghent University; University of Antwerp;
   University of Antwerp; Vrije Universiteit Brussel
RP Verhaeghe, N (corresponding author), Univ Ghent, Fac Med & Hlth Sci, Ghent, Belgium.
EM nick.verhaeghe@ugent.be
RI Vissers, Dirk/HKW-6622-2023; hens, wendy/I-9841-2016
OI Vissers, Dirk/0000-0001-5901-6515; hens, wendy/0000-0002-9881-6248
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NR 49
TC 5
Z9 6
U1 0
U2 2
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0778-7367
EI 2049-3258
J9 ARCH PUBLIC HEALTH
JI Arch. PUblic Health
PD JUL 30
PY 2018
VL 76
AR 42
DI 10.1186/s13690-018-0285-1
PG 10
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA GP2PH
UT WOS:000440676800001
PM 30069308
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Periyalil, HA
   Gibson, PG
   Wood, LG
AF Periyalil, Hashim A.
   Gibson, Peter G.
   Wood, Lisa G.
TI Immunometabolism in Obese Asthmatics: Are We There Yet?
SO NUTRIENTS
LA English
DT Review
DE obesity; immunometabolism; macrophages; mast cells; asthma
ID BODY-MASS INDEX; AIRWAY SMOOTH-MUSCLE; DIET-INDUCED OBESITY; C-REACTIVE
   PROTEIN; CILIARY NEUROTROPHIC FACTOR; ADIPOSE-TISSUE MACROPHAGES;
   SCAVENGER RECEPTOR CD163; NECROSIS-FACTOR-ALPHA; EXHALED NITRIC-OXIDE;
   ADULT-ONSET ASTHMA
AB Obesity is now recognised as a worldwide epidemic. The recent International Association for the Study of Obesity/International Obesity Taskforce (IASO/IOTF) analysis estimates that approximately 1.0 billion adults are currently overweight and a further 475 million are obese. Obesity has huge psychosocial impact with obese children and adolescents facing discrimination and stigmatization in many areas of their lives leading to body dissatisfaction, low self-esteem and depression. Indeed, obesity is recognised as an important risk factor for the development of several chronic diseases such as hypertension, cancer, asthma and metabolic syndrome. Chronic low grade systemic inflammation is considered as a hallmark of obesity and may possibly explain the link between obesity and chronic disease, in particular the increased incidence, prevalence and severity of asthma in obese individuals. There is now strong evidence for infiltration of immune and inflammatory cells into adipose tissue that drives systemic inflammation and subsequent end organ damage. In addition to adipocytes, the key adipose tissue resident immune cells are macrophages and mast cells. Immunometabolism, as an emerging field of investigation, explores the pivotal role of these immune cells in translating immunological changes to metabolic effects in obesity. Abundance of free fatty acids, along with other inflammatory cytokines shift the balance of metabolic homeostasis to pro-inflammatory status by influencing the development of inflammatory cell lineage, which, further exhibits distinct functional phenotypes. There is emerging evidence for macrophage activation and functional polarization of an anti-inflammatory M-2 phenotype towards a pro-inflammatory M-1 phenotype of macrophages in obese adipose tissue. Similarly, studies in both obese humans and murine models reveal the pathognomic presence of an increased number of mast cells in visceral adipose tissue. These suggest a possible contribution of mast cells to the unique metabolome of obese asthma. This review examines proposed multilevel interactions between metabolic and immune systems in obese asthmatics that underlie the negative effects of obesity and may offer significant therapeutic promise.
C1 [Periyalil, Hashim A.; Gibson, Peter G.; Wood, Lisa G.] Univ Newcastle, Fac Hlth, Prior Res Ctr Asthma & Resp Dis, Callaghan, NSW 2308, Australia.
   [Gibson, Peter G.] John Hunter Hosp, Hunter Med Res Inst, Dept Resp & Sleep Med, New Lambton, NSW 2305, Australia.
C3 University of Newcastle; University of Newcastle; Hunter Medical
   Research Institute; John Hunter Hospital
RP Gibson, PG (corresponding author), Univ Newcastle, Fac Hlth, Prior Res Ctr Asthma & Resp Dis, Callaghan, NSW 2308, Australia.
EM hashim.A.periyalil@newcastle.edu.au; peter.gibson@newcastle.edu.au;
   lisa.wood@newcastle.edu.au
RI Wood, Lisa/G-7068-2013; Gibson, Peter/G-6194-2014
OI Wood, Lisa/0000-0002-0941-9225; Gibson, Peter/0000-0001-5865-489X
FU Asthma Australia postgraduate scholarship; National Health and Medical
   Research Council
FX H.P. holds an Asthma Australia postgraduate scholarship.P.G. holds a
   National Health and Medical Research Council practitioner fellowship.
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NR 206
TC 20
Z9 23
U1 0
U2 8
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 2072-6643
J9 NUTRIENTS
JI Nutrients
PD SEP
PY 2013
VL 5
IS 9
BP 3506
EP 3530
DI 10.3390/nu5093506
PG 25
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 274SW
UT WOS:000328627500013
PM 24025484
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Parruti, G
   Vadini, F
   Sozio, F
   Mazzott, E
   Ursini, T
   Polill, E
   Di Stefano, P
   Tontodonati, M
   Verrocchio, MC
   Fulcheri, M
   Calella, G
   Santilli, F
   Manzoli, L
AF Parruti, Giustino
   Vadini, Francesco
   Sozio, Federica
   Mazzott, Elena
   Ursini, Tamara
   Polill, Ennio
   Di Stefano, Paola
   Tontodonati, Monica
   Verrocchio, Maria C.
   Fulcheri, Mario
   Calella, Giulio
   Santilli, Francesca
   Manzoli, Lamberto
TI Psychological Factors, Including Alexithymia, in the Prediction of
   Cardiovascular Risk in HIV Infected Patients: Results of a Cohort Study
SO PLOS ONE
LA English
DT Article
ID INTIMA-MEDIA THICKNESS; ACUTE MYOCARDIAL-INFARCTION;
   CORONARY-HEART-DISEASE; ACTIVE ANTIRETROVIRAL THERAPY; D PERSONALITY;
   NEGATIVE AFFECTIVITY; PLATELET ACTIVATION; EMOTION REGULATION; METABOLIC
   SYNDROME; SOCIAL INHIBITION
AB Background: Psychological factors are known predictors of cardiovascular disease in many clinical settings, but data are lacking for HIV infection. We carried out a prospective cohort study to evaluate potential psychological predictors of preclinical and clinical vascular disease in HIV patients.
   Methodology/Principal Findings: HIV patients were consecutively enrolled. Demographics, viral and immune parameters and traditional cardiovascular predictors were considered; Intima-Media Thickness (c-IMT, continuous measure) and Carotid Plaques (CPs, focal thickening >= 1.5 mm) were investigated by B-mode ultrasonography; depressive symptoms by the Beck Depression Inventory (BDI-II), Type D personality (Distressed Personality or Type D) by the DS14, alexithymia by the Toronto Alexithymia Scale (TAS-20). Vascular outcomes included transient ischemic attacks or stroke, acute coronary syndrome, myocardial or other organ infarction. We enrolled 232 HIV subjects, 73.9% males, aged 44.5 +/- 9.9 y, 38.2% with AIDS diagnosis, 18.3% untreated. Mean Nadir CD4 T-cell counts were 237.5 +/- 186.2/mmc. Of them, 224 (96.5%) attended IMT measurements; 201 (86.6%) attended both IMT assessment and psychological profiling. Mean follow-up was 782 +/- 308 days. Fifty-nine patients (29.4%) had CPs at baseline. Nineteen patients (9.5%) had >= 1 vascular event; 12 (6.0%) died due to such events (n = 4) or any cause. At baseline cross-sectional multivariate analysis, increasing age, total cholesterol, current smoking and Alexithymia score >= 50 were significantly associated with both increased cIMT (linear regression) and CPs (logistic regression). At follow-up analysis, log-rank tests and Cox's regression revealed that only older age (p = 0.001), current smoking (p = 0.019) and alexithymia score >= 50 (p = 0.013) were independently associated with vascular events.
   Conclusions/Significance: In HIV-infected subjects, the Alexithymic trait emerges as a strong predictor of increased IMT, presence of CPs and vascular events. Such results are preliminary and require confirmation from studies with larger sample size and longer follow-up.
C1 [Parruti, Giustino; Vadini, Francesco; Sozio, Federica; Mazzott, Elena; Ursini, Tamara; Polill, Ennio; Di Stefano, Paola; Tontodonati, Monica; Calella, Giulio] Pescara Gen Hosp, Infect Dis Unit, Pescara, Italy.
   [Verrocchio, Maria C.; Fulcheri, Mario] Univ G dAnnunzio, Clin Psychol Div, Chieti, Italy.
   [Santilli, Francesca] Univ G dAnnunzio, Dept Med & Aging, Chieti, Italy.
   [Manzoli, Lamberto] Univ G dAnnunzio, Sect Hyg Epidemiol Pharmacol & Legal Med, Chieti, Italy.
C3 G d'Annunzio University of Chieti-Pescara; G d'Annunzio University of
   Chieti-Pescara; G d'Annunzio University of Chieti-Pescara
RP Parruti, G (corresponding author), Pescara Gen Hosp, Infect Dis Unit, Pescara, Italy.
EM parruti@tin.it
RI Santilli, Francesca/ABC-6243-2021; Verrocchio, Maria/S-5080-2019;
   Ursini, Tamara/AAB-3891-2019; Manzoli, Lamberto/K-1895-2018
OI Fulcheri, Mario/0000-0002-2389-9800; Verrocchio, Maria
   Cristina/0000-0003-0326-619X; Ursini, Tamara/0000-0002-6012-0667;
   VERROCCHIO, MARIA/0000-0003-2549-1152; Manzoli,
   Lamberto/0000-0002-8129-9344; Santilli, Francesca/0000-0002-4593-905X
FU "Fondazione onlus Camillo De Lellis Per l'Innovazione e la Ricerca in
   Medicina'', Pescara, Italy
FX This work was partly supported by a grant by the "Fondazione onlus
   Camillo De Lellis Per l'Innovazione e la Ricerca in Medicina'', Pescara,
   Italy. No additional external funding was received for this study. The
   funders had no role in study design, data collection and analysis,
   decision to publish, or preparation of the manuscript.
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NR 73
TC 30
Z9 30
U1 0
U2 17
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JAN 22
PY 2013
VL 8
IS 1
AR e54555
DI 10.1371/journal.pone.0054555
PG 12
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Science & Technology - Other Topics
GA 077HS
UT WOS:000314019100080
PM 23349927
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Alam, N
   Jia, LY
   Cheng, A
   Ren, HH
   Fu, Y
   Ding, XH
   Ul Haq, I
   Liu, EQ
AF Alam, Naqash
   Jia, Linying
   Cheng, Ao
   Ren, Honghao
   Fu, Yu
   Ding, Xinhua
   Ul Haq, Ihtisham
   Liu, Enqi
TI Global research trends on gut microbiota and metabolic
   dysfunction-associated steatohepatitis: Insights from bibliometric and
   scientometric analysis
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Review
DE NASH; gut microbiota; Citespace; VOSviewer; bibliometrix; visualization
ID FATTY LIVER-DISEASE; NONALCOHOLIC STEATOHEPATITIS; INTESTINAL
   MICROBIOTA; OXIDATIVE STRESS; OBETICHOLIC ACID; FIBROSIS STAGE;
   BILE-ACIDS; PROBIOTICS; OBESITY; TRANSPLANTATION
AB Background: Metabolic dysfunction-associated steatohepatitis (MASH) is an inflammatory subtype of metabolic dysfunction-associated steatotic liver disease (MASLD) has recently been proposed as a replacement term for NAFLD, a common, multifactorial and poorly understood liver disease whose incidence is increasing worldwide. In recent years, there has been increasing scientific interest in exploring the relationship between gut microbiota and MASH. To learn more about the gut microbiota in MASH, this study aims to provide a comprehensive analysis of the knowledge structure and research hotspots from a bibliometric perspective. Methods: We searched the Web of Science Core Collection for articles and reviews that covered the connections between gut microbiota and MASH over the last decade. The Online Analysis Platforms, VOSviewer, CiteSpace, the R tool "bibliometrix" were used to analyzed existing publications trends and hotspots. Results: A total of 4,069 documents related to the interaction between gut microbiota and MASH were retrieved from 2014 to 2023. The number of annual publications increased significantly over the last decade, particularly in the United States and China. The University of California-San Diego was the most productive institution, while researcher Rohit Loomba published the most papers in the field. Younossi ZM was ranked as the first co-cited author and largest contributor of highly cited articles in the field. Gastroenterology and hepatology were the most common specialty category. The most cited journal in the last decade was Hepatology. The Keyword Bursts analysis highlighted the importance of studying the association between gut microbiota and MASH, as well as related factors such as metabolic syndrome, insulin resistance, endotoxemia and overgrowth of gut bacteria. Keyword clusters with co-citation were used to illustrate important topics including intestinal permeability, insulin sensitivity and liver immunology. The most common keywords include insulin resistance, obesity, dysbiosis, inflammation and oxidative stress, which are current hotspots. Conclusion: Our analysis highlights key aspects of this field and emphasizes multiorgan crosstalk in MASLD/MASH pathogenesis. In particular, the central role of the gut-liver axis and the significant influence of gut microbiota dysbiosis on disease progression are highlighted. Furthermore, our results highlight the transformative potential of microbiota-specific therapies and cover the way for innovative healthcare and pharmaceutical strategies.
C1 [Alam, Naqash; Jia, Linying; Cheng, Ao; Ren, Honghao; Fu, Yu; Ding, Xinhua; Liu, Enqi] Xi An Jiao Tong Univ, Lab Anim Ctr, Hlth Sci Ctr, Sch Basic Med Sci, Xian, Peoples R China.
   [Ul Haq, Ihtisham] Xi An Jiao Tong Univ, Hlth Sci Ctr, Sch Basic Med Sci, Dept Neurobiol, Xian, Peoples R China.
C3 Xi'an Jiaotong University; Xi'an Jiaotong University
RP Liu, EQ (corresponding author), Xi An Jiao Tong Univ, Lab Anim Ctr, Hlth Sci Ctr, Sch Basic Med Sci, Xian, Peoples R China.
EM liuenqi@mail.xjtu.edu.cn
RI Cheng, Ao/LXA-0402-2024; Ren, Honghao/IXN-3892-2023
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NR 105
TC 6
Z9 6
U1 5
U2 22
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD JUL 11
PY 2024
VL 15
AR 1390483
DI 10.3389/fphar.2024.1390483
PG 22
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA ZN3H3
UT WOS:001275934000001
PM 39070791
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Danasegaran, M
   Pal, GK
   Sahoo, J
   Pal, P
   Nanda, N
   Renugasundari, M
AF Danasegaran, Murugesan
   Pal, Gopal Krushna
   Sahoo, Jayaprakash
   Pal, Pravati
   Nanda, Nivedita
   Renugasundari, Manoharan
TI Effects of 12 Weeks Practice of Yoga on Heart Rate Variability in Males
   with Type 2 Diabetes Receiving Oral Antidiabetic Drugs: A Randomized
   Control Trial
SO JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE
LA English
DT Article
DE type 2 diabetes mellitus; yoga; cardiometabolic risks; sympathovagal
   imbalance; rate pressure product; heart rate variability
ID SYMPATHOVAGAL IMBALANCE; CARDIOVASCULAR RISKS; INSULIN-RESISTANCE;
   OXIDATIVE STRESS; BLOOD-PRESSURE; ASSOCIATION; RELATIVES; BALANCE;
   GLUCOSE
AB Objective: To investigate the effects of 12 weeks practice of a structured yoga module on heart rate variability (HRV) and cardiometabolic risks in patients with type 2 diabetes (T2D) receiving similar kind of oral antidiabetic drugs (OAD) with yoga therapy and without yoga therapy, matched for all the known confounders.</p>
   Design: Parallel design interventional (randomized control trial) study.</p>
   Subjects: Eighty treatment-naive males with T2D were randomized into control group (n = 40) and study group (n = 40).</p>
   Intervention: Study group participants received a structured yoga therapy that included asana and pranayama practice for 12 weeks in addition to OAD, whereas control group participants received OAD alone.</p>
   Outcome measures: Before and after intervention, BP parameters, rate pressure product (RPP) as the marker of myocardial stress, total power (TP) of HRV, low-frequency to high-frequency (LF-HF) ratio of HRV, homeostatic model of insulin resistance (HOMA-IR), lipid profile and lipid risk factors, malondialdehyde (MDA), and high-sensitive C-reactive protein (hsCRP) were measured. TP of HRV was defined as the primary outcome. Association of TP (the marker of HRV) and LF-HF ratio (the marker of sympathovagal balance) with cardiometabolic parameters was assessed by correlation and regression analyses.</p>
   Results: After 12 weeks yoga therapy, there was significant reduction in cardiometabolic risks (TP of HRV, RPP, lipid risks factors, levels of MDA, and hsCRP) in study group subjects compared with control subjects that did not receive yoga therapy. All cardiometabolic risk factors were significantly correlated with TP in study group, having maximum significance with homeostatic model of insulin secretion (r = 0.502, p <= 0.001). Multiple regression analysis demonstrated the independent contribution of decrease in RPP, HOMA-IR, hsCRP, and MDA to increased TP and decreased LF-HF ratio in T2D patients after yoga therapy.</p>
   Conclusion: From the results of this study, the authors conclude that 12 weeks practice of a structured yoga module improves TP of HRV, sympathovagal balance, and metabolic functions, and reduce cardiovascular (CV) risks in patients with diabetes who received routine antidiabetic medicines along with yoga therapy, compared with the patients with diabetes who received antidiabetic medicines alone. The reduction in cardiometabolic risks in these patients is linked to the improvement in TP of HRV. Future studies should also include a control group with rapid walking or a similar exercise program of equal time to the yoga intervention group to discern whether it is in fact yoga that is leading to these results and not simply increased CV activity. Clinical Trial Registry of India (No. CTRI/2021/06/034074).</p>
C1 [Danasegaran, Murugesan; Pal, Gopal Krushna; Pal, Pravati; Renugasundari, Manoharan] JIPMER, Dept Physiol, Pondicherry 605006, India.
   [Sahoo, Jayaprakash] JIPMER, Dept Endocrinol, Pondicherry, India.
   [Nanda, Nivedita] JIPMER, Dept Biochem, Pondicherry, India.
   [Danasegaran, Murugesan] VMMC, Dept Physiol, Karaikal, India.
C3 Jawaharlal Institute of Postgraduate Medical Education & Research;
   Jawaharlal Institute of Postgraduate Medical Education & Research;
   Jawaharlal Institute of Postgraduate Medical Education & Research;
   Vinayaka Mission's Research Foundation; Vinayaka Mission's Medical
   College & Hospital
RP Pal, GK (corresponding author), JIPMER, Dept Physiol, Pondicherry 605006, India.
EM gopal.gk@jipmer.edu.in
RI Nanda, Nivedita/P-6453-2014; Sahoo, Jayaprakash/HHZ-2657-2022; Pal,
   Pravati/IUQ-5179-2023
OI Pal, Pravati/0009-0003-4061-0241
FU JIPMER
FX This study was carried out by JIPMER intramural academic funding.
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NR 47
TC 3
Z9 3
U1 1
U2 23
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1075-5535
EI 1557-7708
J9 J ALTERN COMPLEM MED
JI J. Altern. Complement Med.
PD DEC 1
PY 2021
VL 27
IS 12
BP 1105
EP 1115
DI 10.1089/acm.2020.0489
EA SEP 2021
PG 11
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA XL2VJ
UT WOS:000717328100001
PM 34582701
DA 2025-06-11
ER

PT J
AU Tan, Q
   He, QF
   Peng, Z
   Zeng, X
   Liu, YZ
   Li, D
   Wang, S
   Wang, JW
AF Tan, Qi
   He, Qifeng
   Peng, Ze
   Zeng, Xin
   Liu, Yuzhe
   Li, Dong
   Wang, Shang
   Wang, Jianwei
TI Topical rhubarb charcoal-crosslinked chitosan/silk fibroin sponge
   scaffold for the repair of diabetic ulcers improves hepatic lipid
   deposition in db/db mice via the AMPK signalling pathway
SO LIPIDS IN HEALTH AND DISEASE
LA English
DT Article
DE Rhubarb charcoal; Type 2 diabetes; AMPK signalling pathway; Hepatic
   lipid deposition
ID FATTY LIVER-DISEASE; OXIDATIVE STRESS; METABOLIC HOMEOSTASIS; EMODIN
AB BackgroundType 2 diabetes mellitus (T2DM) is closely linked to metabolic syndrome, characterised by insulin resistance, hyperglycaemia, abnormal lipid metabolism, and chronic inflammation. Diabetic ulcers (DUs) comprise consequential complications that arise as a result of T2DM. To investigate, db/db mice were used for the disease model. The findings demonstrated that a scaffold made from a combination of rhubarb charcoal-crosslinked chitosan and silk fibroin, designated as RCS/SF, was able to improve the healing process of diabetic wounds in db/db mice. However, previous studies have primarily concentrated on investigating the impacts of the RSC/SF scaffold on wound healing only, while its influence on the entire body has not been fully elucidated.Material and methodsThe silk fibroin/chitosan sponge scaffold containing rhubarb charcoal was fabricated in the present study using a freeze-drying approach. Subsequently, an incision with a diameter of 8 mm was made on the dorsal skin of the mice, and the RCS/SF scaffold was applied directly to the wound for 14 days. Subsequently, the impact of RCS/SF scaffold therapy on hepatic lipid metabolism was assessed through analysis of serum and liver biochemistry, histopathology, quantitative real-time PCR (qRT-PCR), immunohistochemistry, and Western blotting.ResultsThe use of the RCS/SF scaffold led to an enhancement in the conditions associated with serum glucolipid metabolism in db/db mice. An assessment of hepatic histopathology further confirmed this enhancement. Additionally, the qRT-PCR analysis revealed that treatment with RCS/SF scaffold resulted in the downregulation of genes associated with fatty acid synthesis, fatty acid uptake, triglyceride (TG) synthesis, gluconeogenesis, and inflammatory factors. Moreover, the beneficial effect of the RCS/SF scaffold on oxidative stress was shown by assessing antioxidant enzymes and lipid peroxidation. Additionally, the network pharmacology analysis verified that the adenosine monophosphate-activated protein kinase (AMPK) signalling pathway had a vital function in mitigating non-alcoholic fatty liver disease (NAFLD) by utilizing R. officinale. The measurement of AMPK, sterol regulatory element binding protein 1 (SREBP1), fatty acid synthase (FASN), and acetyl CoA carboxylase (ACC) gene and protein expression provided support for this discovery. Furthermore, the molecular docking investigations revealed a robust affinity between the active components of rhubarb and the downstream targets of AMPK (SREBP1 and FASN).ConclusionBy regulating the AMPK signalling pathway, the RCS/SF scaffold applied topically effectively mitigated hepatic lipid accumulation, decreased inflammation, and attenuated oxidative stress. The present study, therefore, emphasises the crucial role of the topical RCS/SF scaffold in regulating hepatic lipid metabolism, thereby confirming the concept of "external and internal reshaping".
C1 [Tan, Qi; Peng, Ze; Zeng, Xin; Liu, Yuzhe; Li, Dong; Wang, Shang; Wang, Jianwei] Chongqing Med Univ, Coll Tradit Chinese Med, Chongqing Key Lab Tradit Chinese Med Prevent & Cur, Chongqing 400016, Peoples R China.
   [He, Qifeng] Chongqing Med Univ, Coll Basic Med Sci, Chongqing 400016, Peoples R China.
   [Zeng, Xin; Wang, Jianwei] Chongqing Coll Tradit Chinese Med, Chongqing 402760, Peoples R China.
C3 Chongqing Medical University; Chongqing Medical University; Chongqing
   College of Traditional Chinese Medicine
RP Wang, S; Wang, JW (corresponding author), Chongqing Med Univ, Coll Tradit Chinese Med, Chongqing Key Lab Tradit Chinese Med Prevent & Cur, Chongqing 400016, Peoples R China.; Wang, JW (corresponding author), Chongqing Coll Tradit Chinese Med, Chongqing 402760, Peoples R China.
EM wangshang0227@sina.com; wjwcq68@163.com
RI Wang, Jianwei/GPK-1072-2022; tan, qi/KYR-4604-2024; Wang,
   Xianshuang/ABL-9180-2022
OI WANG, Shang/0000-0001-7477-2861
FU Xinglin Program of Chongqing TCM/TCM-integrated Key Discipline
FX We thank Bullet Edits Limited for the linguistic editing and
   proofreading of the manuscript.
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NR 66
TC 5
Z9 5
U1 4
U2 19
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1476-511X
J9 LIPIDS HEALTH DIS
JI Lipids Health Dis.
PD FEB 20
PY 2024
VL 23
IS 1
AR 52
DI 10.1186/s12944-024-02041-z
PG 17
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA IV5D8
UT WOS:001169116300001
PM 38378566
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Belkacemi, L
   Jelks, A
   Chen, CH
   Ross, MG
   Desai, M
AF Belkacemi, Louiza
   Jelks, Andrea
   Chen, Chun-Hung
   Ross, Michael G.
   Desai, Mina
TI Altered placental development in undernourished rats: role of maternal
   glucocorticoids
SO REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
LA English
DT Article
ID INTRAUTERINE GROWTH RESTRICTION; TYPE-2 11-BETA-HYDROXYSTEROID
   DEHYDROGENASE; GLUCOSE-TRANSPORTER; GENE-EXPRESSION; FETAL-GROWTH;
   EXPOSURE; MECHANISMS; PREGNANCY; PROTEIN; HYPERTENSION
AB Maternal undernutrition (MUN) during pregnancy may lead to fetal intrauterine growth restriction (IUGR), which itself predisposes to adult risk of obesity, hypertension, and diabetes. IUGR may stem from insufficient maternal nutrient supply or reduced placental nutrient transfer. In addition, a critical role for maternal stress-induced glucocorticoids (GCs) has been suggested to contribute to both IUGR and the ensuing risk of adult metabolic syndrome. While GC-induced fetal organ defects have been examined, there have been few studies on placental responses to MUN-induced maternal stress. Therefore, we hypothesize that 50% MUN associates with increased maternal GC levels and decreased placental HSD11B. This in turn leads to decreased placental and fetal growth, hence the need to investigate nutrient transporters. We measured maternal serum levels of corticosterone, and the placental basal and labyrinth zone expression of glucocorticoid receptor (NR3C1), 11-hydroxysteroid dehydrogenase B 1 (HSD11B-1) predominantly activates cortisone to cortisol and 11-dehydrocorticosterone (11-DHC) to corticosterone, although can sometimes drive the opposing (inactivating reaction), and HSD11B-2 (only inactivates and converts corticosterone to 11-DHC in rodents) in control and MUN rats at embryonic day 20 (E20). Moreover, we evaluated the expression of nutrient transporters for glucose (SLC2A1, SLC2A3) and amino acids (SLC38A1, 2, and 4). Our results show that MUN dams displayed significantly increased plasma corticosterone levels compared to control dams. Further, a reduction in fetal and placental weights was observed in both the mid-horn and proximal-horn positions. Notably, the placental labyrinth zone, the site of feto-maternal exchange, showed decreased expression of HSD11B1-2 in both horns, and increased HSD11B-1 in proximal-horn placentas, but no change in NR3C1. The reduced placental GCs catabolic capacity was accompanied by downregulation of SLC2A3, SLC38A1, and SLC38A2 expression, and by increased SLC38A4 expression, in labyrinth zones from the mid- and proximal-horns. In marked contrast to the labyrinth zone, the basal zone, which is the site of hormone production, did not show significant changes in any of these enzymes or transporters. These results suggest that dysregulation of the labyrinth zone GC "barrier", and more importantly decreased nutrient supply resulting from downregulation of some of the amino acid system A transporters, may contribute to suboptimal fetal growth under MUN.
C1 [Belkacemi, Louiza; Jelks, Andrea; Ross, Michael G.; Desai, Mina] Harbor UCLA Med Ctr, Dept Obstet & Gynecol, Los Angeles Biomed Res Inst, Torrance, CA 90502 USA.
   [Belkacemi, Louiza; Jelks, Andrea; Ross, Michael G.; Desai, Mina] Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90095 USA.
   [Chen, Chun-Hung] Chang Gung Mem Hosp, Chia Yi Med Ctr, Dept Obstet & Gynecol, Chiayi, Taiwan.
C3 University of California System; University of California Los Angeles;
   University of California Los Angeles Medical Center; Lundquist
   Institute; University of California System; University of California Los
   Angeles; University of California Los Angeles Medical Center; David
   Geffen School of Medicine at UCLA; Chang Gung Memorial Hospital
RP Belkacemi, L (corresponding author), Harbor UCLA Med Ctr, Dept Obstet & Gynecol, Los Angeles Biomed Res Inst, Torrance, CA 90502 USA.
EM lbelkacemi@obgyn.humc.edu
FU Los Angeles Research Institute
FX This work was supported by a Los Angeles Research Institute Seed Grant
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NR 35
TC 67
Z9 75
U1 0
U2 10
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1477-7827
J9 REPROD BIOL ENDOCRIN
JI Reprod. Biol. Endocrinol.
PD AUG 1
PY 2011
VL 9
AR 105
DI 10.1186/1477-7827-9-105
PG 11
WC Endocrinology & Metabolism; Reproductive Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Reproductive Biology
GA 813EY
UT WOS:000294350800001
PM 21806804
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Davies, M
   Fraser, SA
   Galic, S
   Choy, SW
   Katerelos, M
   Gleich, K
   Kemp, BE
   Mount, PF
   Power, DA
AF Davies, Matthew
   Fraser, Scott A.
   Galic, Sandra
   Choy, Suet-Wan
   Katerelos, Marina
   Gleich, Kurt
   Kemp, Bruce E.
   Mount, Peter F.
   Power, David A.
TI Novel mechanisms of Na<SUP>+</SUP> retention in obesity: phosphorylation
   of NKCC2 and regulation of SPAK/OSR1 by AMPK
SO AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
LA English
DT Article
DE AMP-activated protein kinase; Na+-K+-2Cl(-) cotransporter; oxidative
   stress responsive 1 kinase; STE-20/SPS1-related proline-alanine-rich
   protein kinase
ID ACTIVATED PROTEIN-KINASE; NA-K-2CL COTRANSPORTER NKCC2; HIGH-FAT;
   CL-COTRANSPORTER; BLOOD-PRESSURE; NA+-K+-2CL(-) COTRANSPORTER; INDUCED
   HYPERTENSION; METABOLIC SYNDROME; SPAK; KIDNEY
AB Enhanced tubular reabsorption of salt is important in the pathogenesis of obesity-related hypertension, but the mechanisms remain poorly defined. To identify changes in the regulation of salt transporters in the kidney, C57BL/6 mice were fed a 40% fat diet [high-fat diet (HFD)] or a 12% fat diet (control diet) for 14 wk. Compared with control diet-fed mice, HFD-fed mice had significantly greater elevations in weight, blood pressure, and serum insulin and leptin levels. When we examined Na+ transporter expression, Na+-K+-2Cl(-) cotransporter (NKCC2) was unchanged in whole kidney and reduced in the cortex, Na+-Cl- cotransporter (NCC) and alpha-epithelial Na+ channel (ENaC) and gamma-ENaC were unchanged, and beta-ENaC was reduced. Phosphorylation of NCC was unaltered. Activating phosphorylation of NKCC2 at S126 was increased 2.5-fold. Activation of STE-20/SPS1-related proline-alanine- rich protein kinase (SPAK)/oxidative stress responsive 1 kinase (OSR1) was increased in kidneys from HFD-fed mice, and enhanced phosphorylation of NKCC2 at T96/T101 was evident in the cortex. Increased activity of NKCC2 in vivo was confirmed with diuretic experiments. HFD-fed mice had reduced activating phosphorylation of AMP-activated protein kinase (AMPK) in the renal cortex. In vitro, activation of AMPK led to a reduction in phospho-SPAK/phospho-OSR1 in AMPK(+/+) murine embryonic fibroblasts (MEFs), but no effect was seen in AMPK(-/-) MEFs, indicating an AMPK-mediated effect. Activation of the with no lysine kinase/SPAK/OSR1 pathway with low-NaCl solution invoked a greater elevation in phospho-SPAK/phospho-OSR1 in AMPK(-/-) MEFs than in AMPK(+/+) MEFs, consistent with a negative regulatory effect of AMPK on SPAK/OSR1 phosphorylation. In conclusion, this study identifies increased phosphorylation of NKCC2 on S126 as a hitherto-unrecognized mediator of enhanced Na+ reabsorption in obesity and identifies a new role for AMPK in regulating the activity of SPAK/OSR1.
C1 [Davies, Matthew; Fraser, Scott A.; Choy, Suet-Wan; Katerelos, Marina; Gleich, Kurt; Mount, Peter F.; Power, David A.] Univ Melbourne, Inst Breathing & Sleep, Kidney Lab, Heidelberg, Vic, Australia.
   [Davies, Matthew; Choy, Suet-Wan; Mount, Peter F.; Power, David A.] Univ Melbourne, Dept Nephrol, Heidelberg, Vic, Australia.
   [Davies, Matthew; Choy, Suet-Wan; Mount, Peter F.; Power, David A.] Univ Melbourne, Dept Med, Heidelberg, Vic, Australia.
   [Galic, Sandra; Kemp, Bruce E.] St Vincents Inst, Fitzroy, Vic, Australia.
C3 Institute for Breathing & Sleep (IBAS); University of Melbourne;
   University of Melbourne; University of Melbourne; St. Vincent's
   Institute of Medical Research
RP Power, DA (corresponding author), Austin Hosp, Dept Nephrol, Studley Rd, Heidelberg, Vic 3084, Australia.
EM David.Power@austin.org.au
RI Kemp, Bruce/G-9602-2019; Power, David/L-4387-2019; Galic,
   Sandra/C-6098-2014; Kemp, Bruce/L-2633-2014
OI Mount, Peter/0000-0001-7637-3661; Power, David/0000-0003-3983-0581;
   Galic, Sandra/0000-0002-7611-5619; Davies, Matthew/0000-0001-8780-034X;
   Kemp, Bruce/0000-0001-6735-5082
FU Australian National Health and Medical Research Council; Victorian
   Government's Operational Infrastructure Support Program; Medical
   Postgraduate Scholarship from the Australian National Health and Medical
   Research Council
FX This work was supported by project grants from the Australian National
   Health and Medical Research Council (to B. E. Kemp and D. A. Power) and
   supported in part by the Victorian Government's Operational
   Infrastructure Support Program (to B. E. Kemp). M. R. P. Davies was
   supported by a Medical Postgraduate Scholarship from the Australian
   National Health and Medical Research Council. The funders had no role in
   the study design, data collection and analysis, decision to publish, or
   preparation of the manuscript.
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NR 57
TC 28
Z9 28
U1 0
U2 6
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 1931-857X
EI 1522-1466
J9 AM J PHYSIOL-RENAL
JI Am. J. Physiol.-Renal Physiol.
PD JUL 1
PY 2014
VL 307
IS 1
BP F96
EP F106
DI 10.1152/ajprenal.00524.2013
PG 11
WC Physiology; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology; Urology & Nephrology
GA AL1XR
UT WOS:000338920200012
PM 24808538
DA 2025-06-11
ER

PT J
AU Merhi, Z
AF Merhi, Z.
TI Advanced glycation end products and their relevance in female
   reproduction
SO HUMAN REPRODUCTION
LA English
DT Review
DE advanced glycation end products; polycystic ovary syndrome; infertility;
   obesity; insulin resistance
ID POLYCYSTIC-OVARY-SYNDROME; MULLERIAN-INHIBITING SUBSTANCE; ENDOGENOUS
   SECRETORY RAGE; TYPE-2 DIABETES-MELLITUS; ENDOPLASMIC-RETICULUM STRESS;
   EPIDERMAL GROWTH-FACTOR; DIETARY GLYCOTOXINS; INSULIN-RESISTANCE;
   BARIATRIC SURGERY; OXIDATIVE STRESS
AB Do advanced glycation end products (AGEs) and their receptors play a role in female reproduction?
   AGEs might contribute to the etiology of polycystic ovary syndrome (PCOS) and infertility.
   The endogenous AGEs are produced in the body by chemical reactions. Exogenous sources of AGEs are diet and smoking. AGEs have been proposed to be among the main intermediaries involved in several diseases, such as metabolic syndrome, type 2 diabetes mellitus, cardiovascular disease, ovarian aging, inflammation, neurodegenerative disorders and PCOS.
   A systematic review was performed for all available basic science and clinical peer-reviewed articles published in PubMed from 1987 to date. Abstracts of annual meetings of the Endocrine Society and American Society for Reproductive Medicine were also reviewed.
   A total of 275 publications and scientific abstracts were identified from the initial search. Sixty-two papers and four published scientific abstracts were selected for full review. The main outcomes were the regulatory effects of AGEs on: (i) granulosa cells, adipocyte physiology, obesity and insulin resistance in women with PCOS and in polycystic ovary animal models and (ii) infertility and measures of ovarian reserve.
   There is an intricate relationship between the AGE-RAGE (receptor for AGEs) system and some aspects of PCOS, such as granulosa cell dysfunction, adipocyte pathophysiology, obesity and insulin resistance. Additionally, irregular ovarian AGE signaling might in part explain the abnormal ovarian histology observed in women with PCOS. The ovarian dysfunction due to AGEs in women without PCOS suggests a role for the AGE-RAGE system in the ovarian follicular environment, and might relate to assisted reproduction technology outcome and measures of ovarian reserve.
   The body of literature currently available limits these findings. The results obtained from granulosa cell lines and animal models may not fully extrapolate to humans.
   This review underscores a critical need to unveil the exact mechanistic actions of AGEs in reproductive physiology and more specifically the hypothalamicpituitaryovarian axis. AGE inhibitors might present an emerging therapeutic approach with significant applications in the context of PCOS and infertility.
   American Society for Reproductive Medicine New Investigator Award and University of Vermont College of Medicine Internal Funds. No competing interests.
C1 Univ Vermont, Coll Med, Dept Obstet Gynecol & Reprod Sci, Div Reprod Endocrinol & Infertil, Burlington, VT 05401 USA.
C3 University of Vermont
RP Merhi, Z (corresponding author), Univ Vermont, Coll Med, Dept Obstet Gynecol & Reprod Sci, Div Reprod Endocrinol & Infertil, 111 Colchester Ave, Burlington, VT 05401 USA.
EM zom00@hotmail.com
FU American Society for Reproductive Medicine New Investigator Award;
   University of Vermont College of Medicine Internal Funds
FX American Society for Reproductive Medicine New Investigator Award and
   University of Vermont College of Medicine Internal Funds.
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NR 90
TC 106
Z9 114
U1 1
U2 53
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0268-1161
EI 1460-2350
J9 HUM REPROD
JI Hum. Reprod.
PD JAN
PY 2014
VL 29
IS 1
BP 135
EP 145
DI 10.1093/humrep/det383
PG 11
WC Obstetrics & Gynecology; Reproductive Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology; Reproductive Biology
GA 271UR
UT WOS:000328417600016
PM 24173721
OA Bronze
DA 2025-06-11
ER

PT J
AU Sha, YM
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AF Sha, Yanming
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   Fu, Jingyun
TI Threshold effect of non-high-density lipoprotein to high-density
   lipoprotein cholesterol ratio and hypertension in US adults: NHANES
   2005-2016
SO MEDICINE
LA English
DT Article
DE hypertension; NHANES; NHHR; random forest; XGBoost
ID PPAR-GAMMA AGONIST; ANGIOTENSIN-II; BLOOD-PRESSURE; CARDIOVASCULAR RISK;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; DYSLIPIDEMIA; HDL; ASSOCIATION;
   HEALTH
AB Hypertension is a prevalent chronic non-communicable disease associated with cardiovascular issues, strokes, kidney disorders, and depression. Most hypertensive patients have dyslipidemia and metabolic abnormalities. The non-high-density lipoprotein to high-density lipoprotein cholesterol ratio (NHHR) is a novel index that more accurately assesses the risk of atherosclerotic cardiovascular diseases and metabolic issues like insulin resistance. The association between NHHR and hypertension prevalence is still unclear. The study aims to examine the link between NHHR and hypertension prevalence in American adults. N10,410 adults from the National Health and Nutrition Examination Survey (NHANES) (2005-2016) were included in this cross-sectional analysis. Multivariable logistic regression constructed to analyze the relationship between NHHR and hypertension, with additional analyses including restricted cubic spline regression (RCS), threshold and saturation effect analyses, effect point calculations, subgroup analyses, and sensitivity analyses. Machine learning methods combined with the Boruta algorithm were employed to identify key predictors of hypertension risk. Of the 10,410 participants, 48% were male, with a hypertension prevalence of 37.03%. NHHR was higher in hypertensive patients compared to non-hypertensive individuals (2.74 vs 2.90, P < .001). In models that were completely confounded with factors including general demographic data, BMI, smoking status, alcohol consumption, diabetes, total cholesterol, history of coronary heart disease, LDL, and dietary cholesterol, NHHR showed a significant positive correlation with hypertension prevalence. RCS regression indicated a non-linear relationship, with a saturation effect point at 3.058. Subgroup analyses showed significant interactions by race and education level (P < .05). Machine learning models demonstrated AUCs > 0.8, affirming the importance of NHHR in predicting hypertension. NHHR levels are significantly elevated in hypertensive individuals compared to non-hypertensive adults in the U.S. Furthermore, a non-linear positive correlation exists between NHHR and hypertension risk, suggesting its potential as a predictive biomarker for early hypertension prevention.
C1 [Sha, Yanming; Fu, Jingyun] Kunming Med Univ, Affiliated Hosp 1, Dept Endocrinol, Yunnan 650032, Peoples R China.
   [Cai, Yuzhou; Zeng, Yujian] Kunming Med Univ, Dept Gastrointestinal Surg, Affiliated Hosp 2, Yunnan, Peoples R China.
C3 Kunming Medical University; Kunming Medical University
RP Fu, JY (corresponding author), Kunming Med Univ, Affiliated Hosp 1, Dept Endocrinol, Yunnan 650032, Peoples R China.
EM shayanming@163.com; ryjagocaepushae@outlook.com;
   zhipozhanashae@outlook.com; fujingyun@kmmu.edu.cn
RI SHA, YANMING/MVX-1893-2025
OI SHA, YANMING/0009-0009-5685-8288
FU National Natural Science Foundation of China [D-2018035]; Yunnan
   Province high-level talent training support plan "famous doctor special
   project" [RLMY20200021]; Subproject of the Yunnan Provincial Clinical
   Medical Center Special Fund for Endocrine and Metabolic Diseases
   [YWLCYXZXXYS20221005]
FX This work was funded by National Natural Science Foundation of China
   (no. D-2018035); Yunnan Province high-level talent training support plan
   "famous doctor special project" (no. RLMY20200021); and Subproject of
   the Yunnan Provincial Clinical Medical Center Special Fund for Endocrine
   and Metabolic Diseases (no. YWLCYXZXXYS20221005).
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NR 56
TC 0
Z9 0
U1 4
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD FEB 21
PY 2025
VL 104
IS 8
AR e41585
DI 10.1097/MD.0000000000041585
PG 15
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA Y5B0Z
UT WOS:001432263900024
PM 39993081
OA gold
DA 2025-06-11
ER

PT J
AU Shankar, A
   Deal, CK
   Mccahon, S
   Callegari, K
   Seitz, T
   Yan, L
   Drown, DM
   Williams, CT
AF Shankar, Anusha
   Deal, Cole K.
   Mccahon, Shelby
   Callegari, Kyle
   Seitz, Taylor
   Yan, Lily
   Drown, Devin M.
   Williams, Cory T.
TI SAD rats: Effects of short photoperiod and carbohydrate consumption on
   sleep, liver steatosis, and the gut microbiome in diurnal grass rats
SO CHRONOBIOLOGY INTERNATIONAL
LA English
DT Article
DE Photoperiod; seasonal affective disorder; metabolic dysbiosis;
   non-alcoholic fatty liver disease
ID SEASONAL AFFECTIVE-DISORDER; BRAIN; PREVALENCE; RHYTHMS; MOOD; GENE;
   MELANOPSIN; SEROTONIN; RESPONSES; WINTER
AB Seasonal affective disorder (SAD) is a recurrent depression triggered by exposure to short photoperiods, with a subset of patients reporting hypersomnia, increased appetite, and carbohydrate craving. Dysfunction of the microbiota - gut - brain axis is frequently associated with depressive disorders, but its role in SAD is unknown. Nile grass rats (Arvicanthis niloticus) are potentially useful for exploring the pathophysiology of SAD, as they are diurnal and have been found to exhibit anhedonia and affective-like behavior in response to short photoperiods. Further, given grass rats have been found to spontaneously develop metabolic syndrome, they may be particularly susceptible to environmental triggers of metabolic dysbiosis. We conducted a 2 x 2 factorial design experiment to test the effects of short photoperiod (4 h:20 h Light:Dark (LD) vs. neutral 12:12 LD), access to a high concentration (8%) sucrose solution, and the interaction between the two, on activity, sleep, liver steatosis, and the gut microbiome of grass rats. We found that animals on short photoperiods maintained robust diel rhythms and similar subjective day lengths as controls in neutral photoperiods but showed disrupted activity and sleep patterns (i.e. a return to sleep after an initial bout of activity that occurs similar to 13 h before lights off). We found no evidence that photoperiod influenced sucrose consumption. By the end of the experiment, some grass rats were overweight and exhibited signs of non-alcoholic fatty liver disease (NAFLD) with micro- and macro-steatosis. However, neither photoperiod nor access to sucrose solution significantly affected the degree of liver steatosis. The gut microbiome of grass rats varied substantially among individuals, but most variation was attributable to parental effects and the microbiome was unaffected by photoperiod or access to sucrose. Our study indicates short photoperiod leads to disrupted activity and sleep in grass rats but does not impact sucrose consumption or exacerbate metabolic dysbiosis and NAFLD.
C1 [Shankar, Anusha; Drown, Devin M.] Univ Alaska Fairbanks, Inst Arctic Biol, Fairbanks, AK USA.
   [Shankar, Anusha] Cornell Univ, Lab Ornithol, Ithaca, NY USA.
   [Deal, Cole K.; Williams, Cory T.] Colorado State Univ, Dept Biol, Ft Collins, CO USA.
   [Mccahon, Shelby; Callegari, Kyle; Seitz, Taylor; Drown, Devin M.] Univ Alaska Fairbanks, Dept Biol & Wildlife, Fairbanks, AK USA.
   [Yan, Lily] Michigan State Univ, Dept Psychol, E Lansing, MI USA.
   [Yan, Lily] Michigan State Univ, Neurosci Program, E Lansing, MI USA.
   [Williams, Cory T.] Colorado State Univ, Dept Biol, 1878 Campus Delivery, Ft Collins, CO 80526 USA.
C3 University of Alaska System; University of Alaska Fairbanks; Cornell
   University; Colorado State University System; Colorado State University
   Fort Collins; University of Alaska System; University of Alaska
   Fairbanks; Michigan State University; Michigan State University;
   Colorado State University System; Colorado State University Fort Collins
RP Williams, CT (corresponding author), Colorado State Univ, Dept Biol, 1878 Campus Delivery, Ft Collins, CO 80526 USA.
EM cory.williams@colostate.edu
RI Shankar, Anusha/AAO-3371-2020; Yan, Lily/AAU-2005-2021; Drown,
   Devin/A-1210-2009
OI Shankar, Anusha/0000-0002-3043-6126
FU National Institute of General Medical Sciences; Washington Animal
   Disease Diagnostic Laboratory at Washington State University
FX We would like to thank the Animal Care staff at the University of Alaska
   Fairbanks for their help with animal husbandry. We thank the Washington
   Animal Disease Diagnostic Laboratory at Washington State University for
   the liver stains. We thank Boaz Mohar for all the time he spent with
   liver imaging, and Kyle Dilliplaine of the Institute of Arctic Biology
   Genomics Core Lab for sequencing the microbiome samples.
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NR 67
TC 2
Z9 2
U1 5
U2 9
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 0742-0528
EI 1525-6073
J9 CHRONOBIOL INT
JI Chronobiol. Int.
PD JAN 2
PY 2024
VL 41
IS 1
BP 93
EP 104
AR 2288223
DI 10.1080/07420528.2023.2288223
EA DEC 2023
PG 12
WC Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics; Physiology
GA FC1G6
UT WOS:001113843400001
PM 38047486
OA Green Submitted
DA 2025-06-11
ER

PT J
AU She, R
   Yan, ZR
   Hao, YL
   Zhang, ZJ
   Du, YF
   Liang, YJ
   Vetrano, DL
   Dekker, J
   Bai, B
   Lau, JTF
   Qiu, CX
AF She, Rui
   Yan, Zhongrui
   Hao, Yanlei
   Zhang, Zuoji
   Du, Yifeng
   Liang, Yajun
   Vetrano, Davide L.
   Dekker, Joost
   Bai, Bo
   Lau, Joseph T. F.
   Qiu, Chengxuan
TI Comorbidity in patients with first-ever ischemic stroke: Disease
   patterns and their associations with cognitive and physical function
SO FRONTIERS IN AGING NEUROSCIENCE
LA English
DT Article
DE stroke; comorbidity; functional dependence; cognitive impairment; China
ID GERIATRIC DEPRESSION SCALE; QUALITY-OF-LIFE; METABOLIC SYNDROME;
   RISK-FACTORS; VALIDITY; MULTIMORBIDITY; EPIDEMIOLOGY; IMPAIRMENT;
   MORTALITY; INDEX
AB The present study examined the prevalence and pattern of comorbidity among Chinese patients with first-ever acute ischemic stroke, and assessed the associations of specific comorbidity patterns with physical and cognitive functioning after stroke occurrence. A hospital-based cross-sectional study was conducted among 2,151 patients with first-ever ischemic stroke (age >= 40 years; 64.2% men) who were admitted to two university hospitals in Shandong, China between 2016 and 2017. Data on demographics, lifestyles, chronic health conditions, and use of medications were collected through in-person interviews, clinical examinations, and laboratory tests. Physical functioning was assessed by the Barthel index (BI) and the modified Rankin Scale (mRS) while cognitive functioning was assessed by the Montreal Cognitive Assessment test. The results showed that comorbidity was present in 90.9% of the stroke patients (women vs. men: 95.2 vs. 88.7%, P < 0.001). Exploratory factor analysis identified three patterns of comorbidity, i.e., patterns of degenerative-cardiopulmonary, heart-gastrointestinal-psychiatric, and metabolic-kidney diseases. The number of comorbidities was significantly associated with a higher likelihood of moderate-to-severe physical dependence [odds ratio (95% CI) = 1.15 (1.06-1.25) for BI and 1.12 (1.04-1.21) for mRS, all P < 0.01] and cognitive impairment [odds ratio (95% CI) = 1.11 (1.02-1.20), P = 0.017], after adjusting for multiple covariates. Almost all the three comorbidity patterns were associated with increased likelihoods of physical dependence (range for odds ratios: 1.26-1.33) and cognitive impairment (range for odds ratios: 1.25-1.34). No significant association was found between degenerative-cardiopulmonary pattern and mRS. These findings suggest that comorbidity is associated with poor physical and cognitive functioning during the acute phase of ischemic stroke. Routine assessments of comorbidity and cognitive and physical function among patients with acute ischemic stroke should be considered in stroke research and clinical practice.
C1 [She, Rui] Hong Kong Polytech Univ, Dept Rehabil Sci, Hong Kong, Peoples R China.
   [She, Rui] Chinese Univ Hong Kong, JC Sch Publ Hlth & Primary Care, Hong Kong, Peoples R China.
   [Yan, Zhongrui] Jining 1 Peoples Hosp, Dept Neurol, Jining, Shandong, Peoples R China.
   [Hao, Yanlei] Jining Med Univ, Dept Neurol, Affiliated Hosp, Jining, Shandong, Peoples R China.
   [Zhang, Zuoji; Bai, Bo] Jining Med Univ, Dept Neurol, Jining, Shandong, Peoples R China.
   [Du, Yifeng; Qiu, Chengxuan] Shandong Univ, Dept Neurol, Shandong Prov Hosp, Jinan, Shandong, Peoples R China.
   [Liang, Yajun] Karolinska Inst, Dept Global Publ Hlth, Stockholm, Sweden.
   [Liang, Yajun; Vetrano, Davide L.; Qiu, Chengxuan] Karolinska Inst, Aging Res Ctr, Dept Neurobiol Care Sci & Soc, Stockholm, Sweden.
   [Liang, Yajun; Vetrano, Davide L.; Qiu, Chengxuan] Stockholm Univ, Stockholm, Sweden.
   [Vetrano, Davide L.] Fdn Policlin A Gemelli IRCCS, Ctr Med Invecchiamento, Med Ctr, Rome, Italy.
   [Vetrano, Davide L.] Univ Cattolica Sacro Cuore, Affiliated Wenzhou Kangning Hosp, Zhejiang Prov Clin Res Ctr Mental Disorders, Rome, Italy.
   [Lau, Joseph T. F.] Wenzhou Med Univ, Sch Mental Hlth, Med Ctr, Wenzhou, Peoples R China.
C3 Hong Kong Polytechnic University; Chinese University of Hong Kong;
   Jining Medical University; Jining Medical University; Shandong
   University; Shandong First Medical University & Shandong Academy of
   Medical Sciences; Karolinska Institutet; Karolinska Institutet;
   Stockholm University; Catholic University of the Sacred Heart; IRCCS
   Policlinico Gemelli; Catholic University of the Sacred Heart; IRCCS
   Policlinico Gemelli; Wenzhou Medical University
RP Qiu, CX (corresponding author), Shandong Univ, Dept Neurol, Shandong Prov Hosp, Jinan, Shandong, Peoples R China.; Qiu, CX (corresponding author), Karolinska Inst, Aging Res Ctr, Dept Neurobiol Care Sci & Soc, Stockholm, Sweden.; Qiu, CX (corresponding author), Stockholm Univ, Stockholm, Sweden.; Lau, JTF (corresponding author), Wenzhou Med Univ, Sch Mental Hlth, Med Ctr, Wenzhou, Peoples R China.
EM jlau@cuhk.edu.hk; chengxuan.qiu@ki.se
RI she, Rui/GQQ-5172-2022; hao, yan/HGB-0465-2022; Du, Yifeng/IST-9657-2023
OI Qiu, Chengxuan/0000-0003-1922-4912
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NR 52
TC 16
Z9 16
U1 2
U2 10
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1663-4365
J9 FRONT AGING NEUROSCI
JI Front. Aging Neurosci.
PD SEP 9
PY 2022
VL 14
AR 887032
DI 10.3389/fnagi.2022.887032
PG 12
WC Geriatrics & Gerontology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology; Neurosciences & Neurology
GA 4U0IJ
UT WOS:000858488400001
PM 36158561
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Battaglia, C
   Battaglia, B
   Mancini, F
   Nappi, RE
   Paradisi, R
   Venturoli, S
AF Battaglia, Cesare
   Battaglia, Bruno
   Mancini, Fulvia
   Nappi, Rossella E.
   Paradisi, Roberto
   Venturoli, Stefano
TI Moderate Alcohol Intake, Genital Vascularization, and Sexuality in
   Young, Healthy, Eumenorrheic Women. A Pilot Study
SO JOURNAL OF SEXUAL MEDICINE
LA English
DT Article
DE Alcohol; Genitalia; Sexuality; Ultrasonography; Doppler; Vascular
   Response of Clitoral Arteries
ID METABOLIC SYNDROME; CONSUMPTION; DRINKING; LIPOPROTEINS; CHOLESTEROL;
   POPULATION; BEHAVIOR; DRUGS; RISK
AB Introduction. The relationship between alcohol and sexual function is complex and not completely understood.
   Aim. To evaluate (in the early follicular phase and independently from sexual stimulation) in young, eumenorrheic, healthy, lean women the genital vascular effects of the light and moderate use of alcohol.
   Methods. Eighty-four women undertook, in the early follicular phase of the menstrual cycle (days 3-5), the administration of the two-factor Italian McCoy Female Sexuality (MFSQ) and the Beck Depression Inventory (BDI) questionnaires; ultrasonographic measurement of the carotid intima-media thickness (IMT); and color Doppler evaluation of the carotid, clitoral, and labia minora arteries. Hormonal (estradiol, androstenedione, and testosterone) and biochemical (lipids, glucose, and insulin) parameters were tested.
   Main Outcome Measures. The MFSQ and BDI questionnaires; the carotid IMT; the Pulsatility Index of internal carotid, clitoral, and labia minora arteries; blood pressure measurement; and hormonal and biochemical assays.
   Results. The subjects were divided in: nondrinkers (group I); current (> 1 year) light drinkers-1-10 drinks/month (group II); and current moderate drinkers-11-20 drinks/month (group III). The majority of the studied parameters did not vary among the different groups. The mean BDI was normal in the studied women. However, the lowest values were observed in the moderate drinkers group. The MFSQ did not show any difference among all the studied women. However, the number of intercourses/week and the incidence of vaginal orgasm were significantly higher in group III (moderate drinkers). The relationship between the drinking habits and different parameters showed an inverse relationship with the BDI. Furthermore, the BDI inversely correlated with orgasm frequency and with orgasm intensity.
   Conclusions. Chronic slight/moderate alcohol consumption has no effects on genital vessels and vaginal lubrication. However, a moderate consumption of alcohol, through psychological and social disinhibiting effects, may favor sexual activities. Battaglia C, Battaglia B, Mancini F, Nappi RE, Paradisi R, and Venturoli S. Moderate alcohol intake, genital vascularization, and sexuality in young, healthy, eumenorrheic women. A pilot study. J Sex Med 2011;8:2334-2343.
C1 [Battaglia, Cesare; Battaglia, Bruno; Paradisi, Roberto; Venturoli, Stefano] Univ Bologna, Dept Gynecol & Pathophysiol Human Reprod, I-40138 Bologna, Italy.
   [Mancini, Fulvia] Inst Univ Dexeus, Dept Obstet Gynecol & Reprod Med, Barcelona, Spain.
   [Nappi, Rossella E.] Univ Pavia, Res Ctr Reprod Med, I-27100 Pavia, Italy.
C3 University of Bologna; University of Pavia
RP Battaglia, C (corresponding author), Univ Bologna, Dept Gynecol & Pathophysiol Human Reprod, Via Massarenti 13, I-40138 Bologna, Italy.
EM cesare.battaglia@unibo.it
RI ; Nappi, Rossella/AAC-1793-2022
OI Battaglia, Bruno/0000-0002-5735-5844; Nappi,
   Rossella/0000-0003-1713-6396
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   LINEE DIRETTRICI MOD
NR 41
TC 16
Z9 16
U1 0
U2 6
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1743-6095
EI 1743-6109
J9 J SEX MED
JI J. Sex. Med.
PD AUG
PY 2011
VL 8
IS 8
BP 2334
EP 2343
DI 10.1111/j.1743-6109.2011.02310.x
PG 10
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 798EN
UT WOS:000293185500024
PM 21595833
DA 2025-06-11
ER

PT J
AU Dryer-Beers, ER
   Griffin, J
   Matthews, PM
   Frost, GS
AF Dryer-Beers, Elliot R.
   Griffin, Jennifer
   Matthews, Paul M.
   Frost, Gary S.
TI Higher Dietary Polyphenol Intake Is Associated With Lower Blood
   Inflammatory Markers
SO JOURNAL OF NUTRITION
LA English
DT Article
DE polyphenols; diet; Phenol-Explorer; Airwave; in; CRP
ID MAJOR FOOD SOURCES; NLRP3 INFLAMMASOME; OXIDATIVE STRESS; FLAVONOID
   INTAKE; METABOLIC SYNDROME; RISK; POPULATION; ADULTS; ANTIOXIDANT;
   HEALTH
AB Background: Evidence suggests a link between polyphenol intake and reduced incidence of several chronic diseases. This could arise through associations between polyphenol intake and reduced systemic oxidative stress and subsequent inflammation. fl ammation. However, confirming fi rming this association is difficult, fi cult, as few large cohorts allow for comprehensive assessments of both polyphenol intake and markers of systemic inflammation. fl ammation. Objectives: To address this, polyphenol intake was assessed in the UK-based Airwave cohort using 7-d diet diaries and data from Phenol- Explorer to test for associations between polyphenol intake and blood biomarkers of inflammation. fl ammation. Methods: Participants included 9008 males and females aged 17-74 - 74 y (median age: 42 y) whose data was included in a cross-sectional analysis. Phenol-Explorer was used to estimate individuals' ' polyphenol intake from diet data describing the consumption of 4104 unique food items. C-reactive protein (CRP) and fi brinogen were used as blood biomarkers of inflammation. fl ammation. Results: There were 448 polyphenols found in reported diet items. Median total polyphenol intake was 1536 mg/d (1058-2092 - 2092 mg/d). Phenolic acids and fl avonoids were the main types of polyphenols, and nonalcoholic beverages, vegetables, and fruit were the primary sources. Variation in energy-adjusted polyphenol intake was explained by age, sex, salary, body mass index, education level, smoking, and alcohol consumption. Linear regressions showed inverse associations between total daily intake and both CRP ((3: (3 :- 0.00702; P < 0.001) and fi brinogen ((3: (3 :- 0.00221; P = 0.038). Associations with specific fi c polyphenol compound groups were also found. Logistic regressions using total polyphenol intake quartiles showed stepwise reductions in the odds of elevated CRP with higher intake (6%, 23%, and 24% compared with quartile 1; P = 0.003), alongside 3% and 7% lower odds per unit of polyphenol consumption equivalent to 1 cup of tea or coffee per day. Conclusions: This study describes polyphenol intake in a large, contemporary UK cohort. We observed associations between higher intake and lower CRP and fi brinogen. This contributes to evidence supporting the health benefits fi ts of dietary polyphenols.
C1 [Dryer-Beers, Elliot R.; Griffin, Jennifer; Frost, Gary S.] Imperial Coll London, Nutr & Dietet Res Grp, London, England.
   [Dryer-Beers, Elliot R.; Matthews, Paul M.] Imperial Coll London, UK Dementia Res Inst, London, England.
   [Dryer-Beers, Elliot R.; Matthews, Paul M.] Imperial Coll London, Dept Brain Sci, London, England.
C3 Imperial College London; Imperial College London; Imperial College
   London
RP Frost, GS (corresponding author), Imperial Coll London, Nutr & Dietet Res Grp, London, England.
EM g.frost@imperial.ac.uk
OI Frost, Gary/0000-0003-0529-6325
FU National Institute for Health Research (NIHR) Senior Investigator Award;
   UK Dementia Research Institute; UK DRI Ltd. - UK Medical Research
   Council; Alzheimer's Society; Alz-heimer's Research UK; NIHR Biomedical
   Research Center at Imperial College London; Imperial College Healthcare
   Trust (ICHT) NIHR Biomedical Research Center; MRC [MR/R023484/1] Funding
   Source: UKRI
FX Studentship name: MRC industrial Collaborative Awards in Science and
   Engineering (iCASE) studentships. MRC grant reference: MR/R015732/1. PMM
   acknowledges generous personal and research support from the Edmond J
   Safra Foundation and Lily Safra, a National Institute for Health
   Research (NIHR) Senior Investigator Award, the UK Dementia Research
   Institute, which receives its funding from UK DRI Ltd., funded by the UK
   Medical Research Council, Alzheimer's Society and Alzheimer's Research
   UK, and the NIHR Biomedical Research Center at Imperial College London.
   All of the authors are grateful for support from the Imperial College
   Healthcare Trust (ICHT) NIHR Biomedical Research Center.r personal and
   research support from the Edmond J Safra Foun-dation and Lily Safra, a
   National Institute for Health Research (NIHR) Senior Investigator Award,
   the UK Dementia Research Institute, which receives its funding from UK
   DRI Ltd., funded by the UK Medical Research Council, Alzheimer's Society
   and Alz-heimer's Research UK, and the NIHR Biomedical Research Center at
   Imperial College London. All of the authors are grateful for support
   from the Imperial College Healthcare Trust (ICHT) NIHR Biomedical
   Research Center.
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   Zhou Y, 2016, NUTRIENTS, V8, DOI 10.3390/nu8080515
NR 82
TC 6
Z9 6
U1 5
U2 8
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0022-3166
EI 1541-6100
J9 J NUTR
JI J. Nutr.
PD AUG
PY 2024
VL 154
IS 8
BP 2470
EP 2480
DI 10.1016/j.tjnut.2024.05.005
EA AUG 2024
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA D8Q1E
UT WOS:001298763500001
PM 38740187
DA 2025-06-11
ER

PT J
AU Hu, XM
   Nie, ZQ
   Ou, YQ
   Lin, LZ
   Qian, ZM
   Vaughn, MG
   McMillin, SE
   Zhou, YL
   Wu, YJ
   Dong, GH
   Dong, HJ
AF Hu, Xiangming
   Nie, Zhiqiang
   Ou, Yanqiu
   Lin, Lizi
   Qian, Zhengmin
   Vaughn, Michael G.
   McMillin, Stephen Edward
   Zhou, Yingling
   Wu, Yongjian
   Dong, Guanghui
   Dong, Haojian
TI Long-term exposure to ambient air pollution, circadian syndrome and
   cardiovascular disease: A nationwide study in China
SO SCIENCE OF THE TOTAL ENVIRONMENT
LA English
DT Article
DE Ambient air pollution; Circadian syndrome; Cardiovascular disease; China
   Health and Retirement Longitudinal Study
ID PARTICULATE MATTER; SLEEP DURATION; HEALTH; RISK
AB Objectives: Epidemiological evidence suggests associations between ambient air pollution and cardiovascular disease (CVD), while circadian rhythm dysregulation, presented by circadian syndrome (CircS), is emerging as a new proxy to cardiovascular disorder that could provide a bridge between them. The present study aims to clarify the effect of high levels ambient air pollution exposure on CircS and CVD in China. Methods: From the China Health and Retirement Longitudinal Study, we recruited 9116 Chinese participants in 2011 and followed them to 2015. A spatiotemporal model was applied to estimate exposure to particles with diameters <= 2.5 mu m (PM2.5). The variable CircS was defined based on 7 components, including the 5 components used to define metabolic syndrome as well as other two components, lack of sleep and depression. The associations between PM2.5 exposure and prevalent CircS as well as incident CVD were modeled via logistic regression analysis displaying oddsratios (ORs) and 95 % CIs (confidence intervals). A mediation analysis was undertaken to identify the potential mediating role of CircS between PM2.5 exposure and CVD. Results: The mean age (standard deviation) was 59 (9) and 48.22 % were male. The OR (95 % CI) between the highest (Q4) and the lowest (Q1) quartile of PM2.5 exposure for CircS was 1.13 (1.01-1.28) in 2011 and 1.44 (1.22-1.72) in 2015. The cumulative effect of the components of CircS became more obvious with the increase of the PM2.5 quartile exposure. For the Q4 versus Q1 of PM2.5 increment, the multivariate-adjusted OR (95 % CI) was 1.66 (1.20-2.29) for CVD incidence. CircS partially mediated the association between PM2.5 exposure and CVD. Conclusions: Exposure to PM2.5 is a risk factor for CircS and CVD, and the effect of PM2.5 on CVD may be explained by CircS. Improving air quality would have high value in preventing CircS as well as CVD in public health.
C1 [Hu, Xiangming; Wu, Yongjian] Chinese Acad Med Sci & Peking Union Med Coll, Dept Cardiol, Fuwai Hosp, Natl Ctr Cardiovasc Dis, Beijing 100000, Peoples R China.
   [Nie, Zhiqiang; Ou, Yanqiu] Southern Med Univ, Dept Cardiol, Hypertens Res Lab, Guangdong Cardiovasc Inst,Guangdong Prov Peoples H, Guangzhou 510080, Peoples R China.
   [Lin, Lizi] Sun Yat Sen Univ, Guangdong Prov Engn Technol Res Ctr Environm & Hlt, Dept Occupat & Environm Hlth, Sch Publ Hlth, Guangzhou 510080, Peoples R China.
   [Qian, Zhengmin] St Louis Univ, Coll Publ Hlth & Social Justice, Dept Epidemiol & Biostat, St Louis, MO 63104 USA.
   [Vaughn, Michael G.; McMillin, Stephen Edward] St Louis Univ, Sch Social Work, St Louis, MO 63103 USA.
   [Zhou, Yingling; Dong, Haojian] Southern Med Univ, Dept Cardiol, Guangdong Cardiovasc Inst, Guangdong Prov Peoples Hosp,Guangdong Acad Med Sci, Guangzhou 510080, Peoples R China.
   [Dong, Guanghui] Sun Yat Sen Univ, Guangzhou Key Lab Environm Pollut & Hlth Risk Asse, Guangdong Prov Engn Technol Res Ctr Environm & Hlt, Dept Occupat & Environm Hlth,Sch Publ Hlth, Guangzhou 510080, Peoples R China.
C3 Chinese Academy of Medical Sciences - Peking Union Medical College;
   Peking Union Medical College; Fu Wai Hospital - CAMS; Southern Medical
   University - China; Sun Yat Sen University; Saint Louis University;
   Saint Louis University; Guangdong Academy of Medical Sciences &
   Guangdong General Hospital; Southern Medical University - China; Sun Yat
   Sen University
RP Wu, YJ (corresponding author), Chinese Acad Med Sci & Peking Union Med Coll, Dept Cardiol, Fuwai Hosp, Natl Ctr Cardiovasc Dis, Beijing 100000, Peoples R China.; Dong, HJ (corresponding author), Southern Med Univ, Dept Cardiol, Guangdong Cardiovasc Inst, Guangdong Prov Peoples Hosp,Guangdong Acad Med Sci, Guangzhou 510080, Peoples R China.; Dong, GH (corresponding author), Sun Yat Sen Univ, Guangzhou Key Lab Environm Pollut & Hlth Risk Asse, Guangdong Prov Engn Technol Res Ctr Environm & Hlt, Dept Occupat & Environm Hlth,Sch Publ Hlth, Guangzhou 510080, Peoples R China.
EM wuyongjian@fuwaihospital.org; donggh5@mail.sysu.edu.cn;
   donggh5@mail.sysu.edu.cn
RI Vaughn, Michael/W-2694-2019; 周, 映伶/GWM-7949-2022; Ou,
   Yanqiu/AAJ-6251-2021; Dong, Guanghui/AAN-4630-2020; Lizi,
   Lin/AHB-8865-2022
FU National Key Research and Develop- ment Program of China
   [2016YFC1301202, 2018YFE0106900]; National Natural Science Foundation of
   China [82103823, 82073502, 81872582, 81872583, M-0420]
FX This research was supported by the National Key Research and Develop-
   ment Program of China (No. 2016YFC1301202, No. 2018YFE0106900) , and
   National Natural Science Foundation of China (82103823, 82073502,
   81872582, 81872583, M-0420) .
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NR 47
TC 14
Z9 14
U1 14
U2 67
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0048-9697
EI 1879-1026
J9 SCI TOTAL ENVIRON
JI Sci. Total Environ.
PD APR 10
PY 2023
VL 868
AR 161696
DI 10.1016/j.scitotenv.2023.161696
EA JAN 2023
PG 8
WC Environmental Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology
GA 8M5US
UT WOS:000924530200001
PM 36682545
DA 2025-06-11
ER

PT J
AU Allshouse, AA
   Polotsky, A
   Crawford, S
   Chen, HY
   El Khoudary, SR
   Santoro, N
AF Allshouse, Amanda A.
   Polotsky, Alex
   Crawford, Sybil
   Chen, Hsiang-Yu
   El Khoudary, Samar R.
   Santoro, Nanette
TI Consistent ovulation may not be enough to make women healthy when
   approaching menopause: an update from the Study of Women's Health Across
   the Nation
SO MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY
LA English
DT Article
DE Study of Women's Health Across the Nation; Daily Hormone Study;
   Menopause; High-density lipoprotein; Consistent ovulation
ID CARDIOVASCULAR RISK-FACTORS; HORMONE-BINDING GLOBULIN; PERIMENOPAUSAL
   WOMEN; METABOLIC SYNDROME; MENSTRUAL CYCLES; OVARIAN-FUNCTION; MIDLIFE
   WOMEN; TRANSITION; SWAN; DEPRESSION
AB Objective: This study aims to test the hypothesis that consistently ovulatory premenopausal/perimenopausal women have a more favorable cardiometabolic profile than anovulatory women.
   Methods: The first four collections from the Study of Women's Health Across the Nation Daily Hormone Study (DHS) were used. DHS enrollees annually completed a daily collection of first morning voided urine for an entire menstrual cycle or up to 50 days (whichever comes first). A woman was categorized as consistently ovulatory annually (COA) if four ovulatory cycles or two to three ovulatory cycles followed by the final menstrual period (FMP) were observed. A woman was categorized as not consistently ovulatory annually (nCOA) if at least one anovulatory year was observed. Cross-sectional and longitudinal differences were compared between COA and nCOA women. Data were centered at FMP and adjusted for age and body mass index (BMI).
   Results: Six hundred thirty-six DHS participants (mean [SD] age, 47.3 [2.5] y; mean [SD] BMI, 27.4 [7.1] kg/m(2)) were included. Thirty-six percent of the DHS participants were COA women. On the fourth follow-up collection, COA women had lower high-density lipoprotein than nCOA women (mean [95% CI], 55.7 [54.0-57.4] vs 59.5 [57.9-61.0] mg/dL, P = 0.002, respectively), which persisted after adjustment. Among 460 women with FMP, 39% were COA women. COA women were slightly older (52.9 vs 52.0 y, P = 0.002) and had lower BMI (geometric mean, 26.1 vs 27.5 kg/m(2), P = 0.06) than nCOA women at FMP. Other cardiometabolic factors did not significantly differ by COA status through FMP.
   Conclusions: Consistent ovulation across the menopausal transition does not seem to reflect superior cardiometabolic health.
C1 [Allshouse, Amanda A.] Univ Colorado Denver, Sch Publ Hlth, Dept Biostat & Informat, Aurora, CO 80045 USA.
   [Polotsky, Alex; Santoro, Nanette] Univ Colorado Denver, Dept Obstet & Gynecol, Aurora, CO 80045 USA.
   [Crawford, Sybil] Univ Massachusetts, Sch Med, Dept Epidemiol Prevent & Behav Med, Worcester, MA USA.
   [Chen, Hsiang-Yu; El Khoudary, Samar R.] Univ Pittsburgh, Grad Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA USA.
C3 University of Colorado System; University of Colorado Anschutz Medical
   Campus; Colorado School of Public Health; Children's Hospital Colorado;
   University of Colorado System; University of Colorado Anschutz Medical
   Campus; Children's Hospital Colorado; University of Massachusetts
   System; University of Massachusetts Worcester; Pennsylvania Commonwealth
   System of Higher Education (PCSHE); University of Pittsburgh
RP Allshouse, AA (corresponding author), Univ Colorado Denver, Sch Publ Hlth, Dept Biostat & Informat, Campus Box B119-406,12477 E 19th Ave, Aurora, CO 80045 USA.
EM Amanda.Allshouse@UCdenver.edu
OI El Khoudary, Samar/0000-0003-2913-0821
FU National Institutes of Health (NIH), Department of Health and Human
   Services, through the National Institute on Aging; National Institutes
   of Health (NIH), Department of Health and Human Services, through the
   National Institute of Nursing Research; NIH Office of Research on
   Women's Health [U01NR004061, U01AG012505, U01AG012535, U01AG012531,
   U01AG012539, U01AG012546, U01AG012553, U01AG012554, U01AG012495]
FX The Study of Women's Health Across the Nation received grant support
   from the National Institutes of Health (NIH), Department of Health and
   Human Services, through the National Institute on Aging, National
   Institute of Nursing Research, and NIH Office of Research on Women's
   Health (grants U01NR004061, U01AG012505, U01AG012535, U01AG012531,
   U01AG012539, U01AG012546, U01AG012553, U01AG012554, and U01AG012495).
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NR 28
TC 2
Z9 2
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1072-3714
EI 1530-0374
J9 MENOPAUSE
JI Menopause-J. N. Am. Menopause Soc.
PD MAR
PY 2015
VL 22
IS 3
BP 267
EP 274
DI 10.1097/gme.0000000000000314
PG 8
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA CC8ZW
UT WOS:000350658100006
PM 25714237
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Strohal, R
   Kirby, B
   Puig, L
AF Strohal, R.
   Kirby, B.
   Puig, L.
CA Psoriasis Expert Panel
TI Psoriasis beyond the skin: an expert group consensus on the management
   of psoriatic arthritis and common co-morbidities in patients with
   moderate-to-severe psoriasis
SO JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
LA English
DT Article
ID CARDIOVASCULAR RISK-FACTORS; POPULATION-BASED-COHORT; QUALITY-OF-LIFE;
   RHEUMATOID-ARTHRITIS; METABOLIC SYNDROME; SCREENING QUESTIONNAIRE; JOINT
   COMPLAINTS; DISEASE SEVERITY; HEALTH-CARE; PREVALENCE
AB BackgroundPsoriatic arthritis (PsA) and co-morbidities of psoriasis represent a significant clinical and economic burden for patients with moderate-to-severe psoriasis. Often these co-morbidities may go unrecognized or undertreated. While published data are available on the incidence and impact of some of them, practical guidance for dermatologists on detection and management of these co-morbidities is lacking.
   ObjectiveTo prepare expert recommendations to improve the detection and management of common co-morbidities in patients with moderate-to-severe psoriasis.
   MethodsA systematic literature review was conducted on some common co-morbidities of psoriasis-cardiovascular (CV) diseases (including obesity, hypertension, hyperglycaemia and dyslipidaemia), psychological co-morbidities (including depression, alcohol abuse and smoking) and PsA-to establish the incidence and impact of each. Data gaps were identified and a Delphi survey was carried out to obtain consensus on the detection and management of each co-morbidity. The expert panel members for the Delphi survey comprised 10 dermatologists with substantial clinical expertise in managing moderate-to-severe psoriasis patients, as well as a cardiologist and a psychologist (see appendix) with an interest in dermatology. Agreement was defined using a Likert scale of 1-7. Consensus regarding agreement for each statement was defined as 75% of respondents scoring either 1 (strongly agree) or 2 (agree).
   ResultsThe expert panel members addressed several topics including screening, intervention, monitoring frequency, and the effects of anti-psoriatic treatment on each co-morbidity. Consensus was achieved on 12 statements out of 22 (3 relating to PsA, 4 relating to psychological factors, 5 relating to CV factors). The panel members felt that dermatologists have an important role in screening their psoriasis patients for PsA and in assessing them for psychological and CV co-morbidities. In most cases, however, patients should be referred for specialist management if other co-morbidities are detected.
   ConclusionThis article provides useful and practical guidance for the detection and management of common co-morbidities in patients with moderate-to-severe psoriasis.
C1 [Strohal, R.] Fed Acad Teaching Hosp, Dept Dermatol, Feldkirch, Austria.
   [Kirby, B.] St Vincents Univ Hosp, Dublin 4, Ireland.
   [Puig, L.] Univ Autonoma Barcelona, Dept Dermatol, Hosp Santa Creu & St Pau, E-08193 Barcelona, Spain.
C3 University College Dublin; Saint Vincent's University Hospital;
   Autonomous University of Barcelona; Hospital of Santa Creu i Sant Pau
RP Strohal, R (corresponding author), Fed Acad Teaching Hosp, Dept Dermatol, Feldkirch, Austria.
EM robert.strohal@lkhf.at
FU Pfizer Inc.
FX This study was developed by an unrestricted grant from Pfizer Inc.
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NR 54
TC 35
Z9 36
U1 0
U2 14
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0926-9959
EI 1468-3083
J9 J EUR ACAD DERMATOL
JI J. Eur. Acad. Dermatol. Venereol.
PD DEC
PY 2014
VL 28
IS 12
BP 1661
EP 1669
DI 10.1111/jdv.12350
PG 9
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA AU0YS
UT WOS:000345348800008
PM 24372845
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Markovic, O
   O'Reilly, G
   Fussell, HM
   Turner, SJ
   Calder, PC
   Howell, WM
   Grimble, RF
AF Markovic, O
   O'Reilly, G
   Fussell, HM
   Turner, SJ
   Calder, PC
   Howell, WM
   Grimble, RF
TI Role of single nucleotide polymorphisms of proinflammatory cytokine
   genes in the relationship between serum lipids and inflammatory
   parameters, and the lipid-lowering effect of fish oil in healthy males
SO CLINICAL NUTRITION
LA English
DT Article
DE fish oil; cytokines; gene polymorphisms; TNF-alpha; LT-alpha; IL-1 beta;
   IL-6
ID TUMOR-NECROSIS-FACTOR; C-REACTIVE PROTEIN; POLYUNSATURATED FATTY-ACIDS;
   BLOOD MONONUCLEAR-CELLS; FACTOR-ALPHA; INSULIN-RESISTANCE; DIETARY
   SUPPLEMENTATION; EICOSAPENTAENOIC ACID; METABOLIC SYNDROME; BODY-FAT
AB Background and Aims: Lipid metabolism, obesity and inflammation are intimately related. Plasma trigtycerides increase during the inflammatory response to pathogens and obesity increases inflammatory stress.
   Pro-inflammatory cytokines are secreted by adipocytes in uninfected obese subjects. Polymorphisms (SNPs) in cytokine genes influence the intensity of cytokine production and inflammatory stress. Fish oil has lipid-lowering and anti-inflammatory properties. The influence of cytokine gene polymorphisms on the interaction between adiposity, inflammation and the properties of fish oil is unknown.
   Methods: Fasting plasma triglycerides, acute phase proteins and BMI were studied in 159 healthy men and the effect of 6 g/d fish oil for 12 weeks on the former two parameters studied. Subjects were genotyped for SNPs at positions -511, -174, +252 and -308 in the IL-1beta, IL-6, LT-alpha (TNF-beta) and TNF-alpha genes, respectively. Data were divided into three sub-groups of BMI, 16.7-22.8, 22.9-24.9 and 25.1-33.7 kg/ m(2), respectively.
   Results: Correlations were apparent between CRP and triglycerides in the highest tertile r = 0.324, P<0.05 and between CRP and serum amyloid in all tertiles. Mean concentrations of all three molecules were higher in the middle and highest tertile than in the lowest. Irrespective of BMI, CRP and triglycerides were positively correlated in subjects with a TNF-alpha-308GG, LT-alpha AG, IL-1beta-511TT and IL-6-174GG genotype. The latter three genotypes are associated with enhanced inflammation. Genotype and BMI interacted. Concentrations of triglyceride rose significantly with increasing tertile only in subjects with a LT-alpha AA genotype. CRP concentrations rosein subjects with a LT-alpha AG genotype. Trigtycerides were towered by fish oil. Pre-supplementation concentrations were correlated with the decrease, r = -0.494 P<0.0001. Genotype influenced the effects of fish oil. A fall occurred in triglycerides, across tertiles of BMI, only in individuals possessing a LT-alpha+252 AA genotype. Irrespective of BMI, possession of an A allele of this SNP was necessary for the correlation to occur.
   Conclusions: Possession of genotypes associated with raised inflammatory stress strengthen the association between fasting plasma triglycerides and CRR The ability of fish oil to exert a lipid-lowering, anti-inflammatory influence in healthy men is influenced by BMI and possession of the LT-alpha+252 A allele.
   (C) 2004 Elsevier Ltd. All rights reserved.
C1 Univ Southampton, Inst Human Nutr, Sch Med, Southampton SO16 7PX, Hants, England.
   Southampton Univ Hosp, Mol Pathol Lab, Div Human Genet, NHS Trust, Southampton, Hants, England.
   Univ Southampton, Div Human Genet, Southampton, Hants, England.
C3 University of Southampton; University of Southampton; University of
   Southampton
RP Univ Southampton, Inst Human Nutr, Sch Med, Southampton SO16 7PX, Hants, England.
EM rfg1@soton.ac.uk
RI Turner, Stephen/GXM-4654-2022; Calder, Philip/E-9739-2013
OI Calder, Philip/0000-0002-6038-710X
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NR 69
TC 32
Z9 36
U1 0
U2 6
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0261-5614
EI 1532-1983
J9 CLIN NUTR
JI Clin. Nutr.
PD OCT
PY 2004
VL 23
IS 5
BP 1084
EP 1095
DI 10.1016/j.clnu.2004.02.002
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 860QR
UT WOS:000224358600019
PM 15380900
DA 2025-06-11
ER

PT J
AU Shahrulnizam, NANM
   Goon, MDME
   Ab Rahim, S
   Lew, SW
   Kadir, SHSA
   Ibrahim, E
AF Shahrulnizam, Nur Aliah Natasha Md
   Goon, Mohd Danial Mohd Efendy
   Ab Rahim, Sharaniza
   Lew, Sook Weih
   Kadir, Siti Hamimah Sheikh Abdul
   Ibrahim, Effendi
TI Palm-based tocotrienol-rich fraction (TRF) supplementation modulates
   cardiac sod1 expression, fxr target gene expression, and
   tauro-conjugated bile acid levels in aleptinemic mice fed a high-fat
   diet
SO GENES AND NUTRITION
LA English
DT Article
DE Tocotrienols; Farnesoid X receptor; Animal model; High-fat diet;
   Antioxidant
ID FARNESOID-X-RECEPTOR; MOUSE MODEL; CARDIOVASCULAR-DISEASE;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; HEPATIC STEATOSIS; NUCLEAR
   RECEPTOR; ACTIVATION; OBESITY; IDENTIFICATION
AB Tocotrienol-rich fraction (TRF) has been reported to protect the heart from oxidative stress-induced inflammation. It is, however, unclear whether the protective effects of TRF against oxidative stress involve the activation of farnesoid X receptor (fxr), a bile acid receptor, and the regulation of bile acid metabolites. In the current study, we investigated the effects of TRF supplementation on antioxidant activities, expression of fxr and its target genes in cardiac tissue, and serum untargeted metabolomics of high-fat diet-fed mice. Mice were divided into high-fat diet (HFD) with or without TRF supplementation (control) for 6 weeks. At the end of the intervention, body weight (BW), waist circumference (WC), and random blood glucose were measured. Heart tissues were collected, and the gene expression of sod1, sod2, gpx, and fxr and its target genes shp and stat3 was determined. Serum was subjected to untargeted metabolomic analysis using UHPLC-Orbitrap. In comparison to the control, the WC of the TRF-treated group was higher (p >0.05) than that of the HFD-only group, in addition there was no significant difference in weight or random blood glucose level. Downregulation of sod1, sod2, and gpx expression was observed in TRF-treated mice; however, only sod1 was significant when compared to the HFD only group. The expression of cardiac shp (fxr target gene) was significantly upregulated, but stat3 was significantly downregulated in the TRF-treated group compared to the HFD-only group. Biochemical pathways found to be influenced by TRF supplementation include bile acid secretion, primary bile acid biosynthesis, and biotin and cholesterol metabolism. In conclusion, TRF supplementation in HFD-fed mice affects antioxidant activities, and more interestingly, TRF also acts as a signaling molecule that is possibly involved in several bile acid-related biochemical pathways accompanied by an increase in cardiac fxr shp expression. This study provides new insight into TRF in deregulating bile acid receptors and metabolites in high-fat diet-fed mice.
C1 [Shahrulnizam, Nur Aliah Natasha Md] Univ Teknol MARA UiTM, Inst Med Mol Biotechnol IMMB, Fac Med, Sungai Buloh 47000, Selangor, Malaysia.
   [Goon, Mohd Danial Mohd Efendy; Kadir, Siti Hamimah Sheikh Abdul] Univ Teknol MARA UiTM, Inst Pathol Lab & Forens Med I PPerForM, Cawangan Selangor, Sungai Buloh 47000, Selangor, Malaysia.
   [Goon, Mohd Danial Mohd Efendy; Ab Rahim, Sharaniza; Kadir, Siti Hamimah Sheikh Abdul] Univ Teknol MARA UiTM, Fac Med, Dept Biochem & Mol Med, Cawangan Selangor, Sungai Buloh 47000, Selangor, Malaysia.
   [Ibrahim, Effendi] Univ Teknol MARA UiTM, Fac Med, Dept Pediat, Cawangan Selangor, Sungai Buloh 47000, Selangor, Malaysia.
   [Lew, Sook Weih] Univ Teknol MARA UiTM, Fac Med, Dept Pediat, Cawangan Selangor, Sungai Buloh 47000, Selangor, Malaysia.
RP Kadir, SHSA (corresponding author), Univ Teknol MARA UiTM, Inst Pathol Lab & Forens Med I PPerForM, Cawangan Selangor, Sungai Buloh 47000, Selangor, Malaysia.; Kadir, SHSA (corresponding author), Univ Teknol MARA UiTM, Fac Med, Dept Biochem & Mol Med, Cawangan Selangor, Sungai Buloh 47000, Selangor, Malaysia.; Ibrahim, E (corresponding author), Univ Teknol MARA UiTM, Fac Med, Dept Pediat, Cawangan Selangor, Sungai Buloh 47000, Selangor, Malaysia.
EM sitih587@uitm.edu.my; effendi953@uitm.edu.my
RI Sheikh Abdul Kadir, Siti Hamimah/ABA-7769-2021; Mohd Efendy Goon, Mohd
   Danial/AIE-9937-2022
FU Universiti Teknologi MARA; Research Management Centre team of Universiti
   Teknologi MARA [RACER/1/2019/SKK08/UITM//9]; Ministry of Higher
   Education, Malaysia
FX We thank the Research Management Centre team of Universiti Teknologi
   MARA for their support and aid in completing this project and to the
   Ministry of Higher Education, Malaysia for providing the fund for this
   project; grant code RACER/1/2019/SKK08/UITM//9.
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   World Health Statistics 2023, 2023, Monitoring health for the SDGs, Sustainable Development Goals
NR 44
TC 0
Z9 0
U1 6
U2 13
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1555-8932
EI 1865-3499
J9 GENES NUTR
JI Genes Nutr.
PD DEC
PY 2024
VL 19
IS 1
AR 3
DI 10.1186/s12263-024-00742-9
PG 11
WC Genetics & Heredity; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Genetics & Heredity; Nutrition & Dietetics
GA JY5G8
UT WOS:001176727400001
PM 38413846
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Hua, YQ
   Zeng, Y
   Xu, J
   Xu, XL
AF Hua, Yi Qiao
   Zeng, Yi
   Xu, Jin
   Xu, Xiao Le
TI Naringenin alleviates nonalcoholic steatohepatitis in middle-aged
   Apoe<SUP>-/-</SUP> mice: role of SIRT1
SO PHYTOMEDICINE
LA English
DT Article
DE Nonalcoholic steatohepatitis; Naringenin; SIRT1; Aging; ApoE(-/-) mice;
   AML-12 cells
ID APOLIPOPROTEIN-E; LIVER; INFLAMMATION; PIOGLITAZONE; FIBROSIS; DISEASE;
   ACID
AB Background: Naringenin is naturally isolated from citrus fruits possessing many pharmacological activities. However, little is known about the effect of naringenin on nonalcoholic steatohepatitis (NASH) in the model of metabolic syndrome.
   Purpose: The present study is aimed to investigate the effect of naringenin on NASH in 12-mo-old male ApoE(-/-) mice and its possible underlying mechanism.
   Methods: In vivo, 12-mo-old male ApoE(-/-) mice were administrated with naringenin by intragastric gavage for 12 weeks. At the end of experiment, the blood samples and liver tissues were collected. Metabolic parameters in serum, levels of triglyceride, cholesterol and hydroxyproline, activities of antioxidant enzymes, and content of inflammatory cytokines (TNF-alpha and IL-6) in liver were examined by corresponding assay kits. Pathological changes in liver were observed by hematoxylin-eosin, oil red O, masson's trichrome, picro-sirius red and senescence beta-galactosidase staining. Dihydroethidium was used for detection of reactive oxygen species (ROS). In vitro, AML-12 cells were treated with oleic acid in the presence or absence of naringenin for 24 h. Transfection of SIRT1 siRNA was also conducted in vitro. Lipid accumulation, cellular ROS generation, malondialdehyde content, antioxidant enzyme activities and secretion levels of TNF-alpha and IL-6 were examined. Both in vivo and in vitro, gene expressions were detected by real-time PCR or western blot.
   Results: Naringenin administration improved metabolic parameters, suppressed hepatic steatosis, regulated expression of genes involved in lipid metabolism (FASN, SCDI, PPAR alpha and CPT1 alpha), reduced hepatic fibrosis and cell senescence, inhibited hepatic inflammation as evidenced by the decreased macrophage recruitment and content of TNF-alpha and IL-6, and reduced hepatic oxidative stress by suppressing ROS generation and normalizing activities of antioxidant enzymes. Notably, naringenin administration increased hepatic SIRT1 protein expression and activity along with the increased deacetylation of liver kinase B1 (LKB1), PGC1 alpha and NF-kappa B. In vitro study, the benefits of naringenin on lipid accumulation, oxidative stress and inflammation were diminished by SIRT1 siRNA transfection.
   Conclusions: These results indicate that naringenin administration may be a potential curative therapy for NASH treatment and the activation of hepatic SIRT1-mediated signaling cascades is involved in its beneficial effects.
C1 [Hua, Yi Qiao; Zeng, Yi; Xu, Jin; Xu, Xiao Le] Nantong Univ, Dept Pharmacol, Pharm Coll, Nantong 226001, Peoples R China.
C3 Nantong University
RP Xu, XL (corresponding author), Nantong Univ, Dept Pharmacol, Div Med, Pharm Coll, 19 Qi Xiu Rd, Nantong 226001, Peoples R China.
EM xiaolexu@ntu.edu.cn
FU National Science Foundation of China [81770446]
FX The research was supported by the National Science Foundation of China
   (Grant no. 81770446).
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NR 37
TC 79
Z9 83
U1 4
U2 36
PU ELSEVIER GMBH
PI MUNICH
PA HACKERBRUCKE 6, 80335 MUNICH, GERMANY
SN 0944-7113
EI 1618-095X
J9 PHYTOMEDICINE
JI Phytomedicine
PD JAN
PY 2021
VL 81
AR 153412
DI 10.1016/j.phymed.2020.153412
EA JAN 2021
PG 11
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA PP0SH
UT WOS:000605579700008
PM 33234364
DA 2025-06-11
ER

PT J
AU Zhang, YP
   Hou, YL
   Fang, ZQ
   Wang, XF
   Li, JD
   Wang, HP
   Peng, W
   Johnson, AK
   Xue, BJ
AF Zhang, Yu-Ping
   Hou, Yan-Li
   Fang, Zhi-Qin
   Wang, Xue-Fang
   Li, Jian-Dong
   Wang, Hai-Ping
   Peng, Wei
   Johnson, Alan Kim
   Xue, Baojian
TI Maternal high-fat diet acts on the brain to induce baroreflex
   dysfunction and sensitization of angiotensin II-induced hypertension in
   adult offspring
SO AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
LA English
DT Article
DE blood pressure; cardiac baroreflex function; inflammation; maternal
   high-fat diet; renin-angiotensin system
ID SYMPATHETIC-NERVE ACTIVITY; CIRCUMVENTRICULAR ORGANS; BLOOD-PRESSURE;
   OBESITY; LEPTIN; INFLAMMATION; SYSTEM; HYPOTHALAMUS; SENSITIVITY;
   PREGNANCY
AB Accumulating evidence indicates that maternal high-fat diet (HFD) is associated with metabolic syndrome and cardiovascular disease in adult offspring. The present study tested the hypothesis that maternal HFD modulates the brain renin-angiotensin system (RAS), oxidative stress, and proinflammatory cytokines that alter angiotensin II (ANG II) and TNF-alpha actions and sensitize the ANG II-elicited hypertensive response in adult offspring. All offspring were cross fostered by dams on the same or opposite diet to yield the following four groups: offspring from normal-fat control diet-fed dams suckled by control diet-fed dams (OCC group) or by HFD-fed dams (OCH group) and offspring from HFD-fed dams fed a HFD suckled by control diet-fed dams (OHC group) or by HFD-fed dams (OHH group). RT-PCR analyses of the lamina terminalis and paraventricular nucleus indicated upregulation of mRNA expression of several RAS components, NADPH oxidase, and proinflammatory cytokines in 10-wk-old male offspring of dams fed a HFD during either pregnancy, lactation, or both (OHC, OCH, and OHH groups). These offspring also showed decreased cardiac baroreflex sensitivity and increased pressor responses to intracerebroventricular microinjection of either ANG II or TNF-alpha. Furthermore, chronic systemic infusion of ANG II resulted in enhanced upregulation of mRNA expression of RAS components, NADPH oxidase, and proinflammatory cytokines in the lamina terminalis and paraventricular nucleus and an augmented hypertensive response in the OHC, OCH, and OHH groups compared with the OCC group. The results suggest that maternal HFD blunts cardiac baroreflex function and enhances pressor responses to ANG II or proinflammatory cytokines through upregulation of the brain RAS, oxidative stress, and inflammation.
   NEW & NOTEWORTHY The results of our study indicate that a maternal high-fat diet during either pregnancy or lactation is sufficient for perinatal programming of sensitization for hypertension, which is associated with hyperreactivity of central cardiovascular nuclei that, in all likelihood, involves elevated expression of the renin-angiotensin system, NADPH oxidase. and proinflammatory cytokines. The present study demonstrates, for the first time, the central mechanism underlying maternal high-fat diet sensitization of the hypertensive response in adult offspring.
C1 [Zhang, Yu-Ping; Hou, Yan-Li; Wang, Xue-Fang; Li, Jian-Dong; Wang, Hai-Ping; Peng, Wei] Hebei North Univ, Life Sci Res Ctr, Zhangjiakou City, Hebei, Peoples R China.
   [Fang, Zhi-Qin] Hebei North Univ, Affiliated Hosp 1, Zhangjiakou City, Hebei, Peoples R China.
   [Johnson, Alan Kim; Xue, Baojian] Univ Iowa, Dept Psychol & Brain Sci, Iowa City, IA USA.
C3 Hebei North University; Hebei North University; University of Iowa
RP Peng, W (corresponding author), Hebei North Univ, Life Sci Res Ctr, Zhangjiakou City, Hebei, Peoples R China.
EM sun003@126.com
RI Yuanlei, Zhang/AGW-9772-2022; Peng, Wei/LPQ-0448-2024
FU Funds for Major Program of Hebei North University Grant [ZD201316];
   Natural Fund of Hebei Province Grant [H2015405017]; National Heart,
   Lung, and Blood Institute Grants [HL-14388, HL-98207, HL-84027]
FX This work were supported by Funds for Major Program of Hebei North
   University Grant ZD201316 (to J. D. Li), Natural Fund of Hebei Province
   Grant H2015405017 (to H. P. Wang), and National Heart, Lung, and Blood
   Institute Grants HL-14388 (to F.M. Abboud/A.K. Johnson), HL-98207 (to
   A.K. Johnson) and HL-84027 (to C.D. Sigmund/A.K. Johnson).
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NR 34
TC 28
Z9 28
U1 0
U2 11
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0363-6135
EI 1522-1539
J9 AM J PHYSIOL-HEART C
JI Am. J. Physiol.-Heart Circul. Physiol.
PD MAY
PY 2018
VL 314
IS 5
BP H1061
EP H1069
DI 10.1152/ajpheart.00698.2017
PG 9
WC Cardiac & Cardiovascular Systems; Physiology; Peripheral Vascular
   Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Physiology
GA GP8EQ
UT WOS:000441143200017
PM 29373045
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Kandhare, AD
   Bandyopadhyay, D
   Thakurdesai, PA
AF Kandhare, Amit D.
   Bandyopadhyay, Debasish
   Thakurdesai, Prasad A.
TI Low molecular weight galactomannans-based standardized fenugreek seed
   extract ameliorates high-fat diet-induced obesity in mice via
   modulation of FASn, IL-6, leptin, and TRIP-Br2
SO RSC ADVANCES
LA English
DT Article
ID ALPHA-KETOGLUTARATE DEHYDROGENASE; INSULIN-RESISTANCE; ADIPOSE-TISSUE;
   DIABETES-MELLITUS; OXIDATIVE STRESS; MITOCHONDRIAL FUSION; METABOLIC
   SYNDROME; SKELETAL-MUSCLE; BLOOD-GLUCOSE; RISK-FACTORS
AB Background: Obesity is a complex, chronic metabolic disorder and its prevalence is increasing throughout most of the world. Low molecular weight galactomannans-based standardized fenugreek seed extract (LMWGAL-TF) has previously shown anti-diabetic and anti-hyperlipidemic potential. Aim: To evaluate the efficacy and mechanism of action of LMWGAL-TF in treating high fat diet (HFD)-induced obesity and hyperlipidemia in mice. Materials and methods: Male C57BL/6 mice were fed the HFD for 12 weeks and were co-administered with LMWGAL-TF (10, 30 and 100 mg kg(-1), p.o.). Variables measured were behavioral, biochemical, molecular and histopathological. In a separate in vitro experiment, copper-ascorbate (Cu-As)-induced mitochondrial oxidative damage was evaluated. Results: The HFD-induced increase (p < 0.001) in body weight, fat mass, lean mass, adipose tissue (brown, mesenteric, epididymal and retroperitoneal) and liver weight was significantly attenuated (p < 0.001) by LMWGAL-TF (30 and 100 mg kg(-1)). The HFD-induced elevated levels of serum lipid, interleukins (ILs)-6 and leptin were significantly decreased (p < 0.001) by LMWGAL-TF (30 and 100 mg kg(-1)). Elevated fatty acid synthase (FASn), IL-6, leptin and transcriptional regulator interacting with the PHD-bromodomain 2 (TRIP-Br2) mRNA expression in brown adipose tissue (BAT), liver, and epididymal fat were significantly down-regulated (p < 0.001) by LMWGAL-TF (30 and 100 mg kg(-1)). Additionally, HFD-induced histological alterations in skeletal muscle, liver, white adipose tissue (WAT) and BAT were also reduced by LMWGAL-TF. Furthermore, the Cu-As-induced alteration in mitochondria oxidative stress (lipid peroxidation, protein carbonylation, glutathione, glutathione reductase, glutathione peroxidase, isocitrate dehydrogenase and -ketoglutarate dehydrogenase) in skeletal muscle and BAT was significantly (p < 0.001) ameliorated by LMWGAL-TF (2, 4 and 6 mg mL(-1)) treatment. It also reduced the Cu-As-induced mitochondrial swelling. Conclusion: LMWGAL-TF showed its beneficial effect in reducing HFD-induced obesity via down-regulation of FASn, IL-6, leptin, and TRIP-Br2 in mice.
C1 [Kandhare, Amit D.; Thakurdesai, Prasad A.] Ind Biotech Private Ltd, Dept Sci Affairs, 1 Rahul Residency,Off Salunke Vihar Rd, Pune 411048, Maharashtra, India.
   [Bandyopadhyay, Debasish] Univ Calcutta, Oxidat Stress & Free Radical Biol Lab, Dept Physiol, Univ Coll Sci & Technol, Kolkata 700009, India.
C3 University of Calcutta
RP Kandhare, AD (corresponding author), Ind Biotech Private Ltd, Dept Sci Affairs, 1 Rahul Residency,Off Salunke Vihar Rd, Pune 411048, Maharashtra, India.
EM amit.kandhare@indusbiotech.com
RI Bandyopadhyay, Debasish/AFC-7830-2022; Thakurdesai, Prasad/O-3020-2013;
   Kandhare, Amit/E-2584-2011
OI Bandyopadhyay, Debasish/0000-0001-7993-0777; Kandhare,
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NR 131
TC 20
Z9 21
U1 1
U2 5
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2046-2069
J9 RSC ADV
JI RSC Adv.
PY 2018
VL 8
IS 57
BP 32401
EP 32416
DI 10.1039/c8ra05204b
PG 16
WC Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry
GA GY2DE
UT WOS:000448348200003
PM 35547667
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Cai, ZW
   Jiang, XL
   Pan, YM
   Chen, L
   Zhang, LF
   Zhu, KY
   Cai, YQ
   Ling, Y
   Chen, FM
   Xu, XP
   Chen, ML
AF Cai, Zhaowei
   Jiang, Xiaoling
   Pan, Yongming
   Chen, Liang
   Zhang, Lifan
   Zhu, Keyan
   Cai, Yueqin
   Ling, Yun
   Chen, Fangming
   Xu, Xiaoping
   Chen, Minli
TI Transcriptomic analysis of hepatic responses to testosterone deficiency
   in miniature pigs fed a high-cholesterol diet
SO BMC GENOMICS
LA English
DT Review
DE Testosterone; Nonalcoholic fatty liver disease; Hepatic steatosis;
   Miniature pigs; RNA-Seq
ID NONALCOHOLIC FATTY LIVER; PPAR-DELTA AGONIST; IMPROVES
   INSULIN-RESISTANCE; METABOLIC SYNDROME; GENE-EXPRESSION;
   GLUCOSE-METABOLISM; SERUM TESTOSTERONE; SKELETAL-MUSCLE; ACID OXIDATION;
   STEATOSIS
AB Background: Recent studies have indicated that low serum testosterone levels are associated with increased risk of developing hepatic steatosis; however, the mechanisms mediating this phenomenon have not been fully elucidated. To gain insight into the role of testosterone in modulating hepatic steatosis, we investigated the effects of testosterone on the development of hepatic steatosis in pigs fed a high-fat and high-cholesterol (HFC) diet and profiled hepatic gene expression by RNA-Seq in HFC-fed intact male pigs (IM), castrated male pigs (CM), and castrated male pigs with testosterone replacement (CMT).
   Results: Serum testosterone levels were significantly decreased in CM pigs, and testosterone replacement attenuated castration-induced testosterone deficiency. CM pigs showed increased liver injury accompanied by increased hepatocellular steatosis, inflammation, and elevated serum alanine aminotransferase levels compared with IM pigs. Moreover, serum levels of total cholesterol, low-density lipoprotein cholesterol, and triglycerides were markedly increased in CM pigs. Testosterone replacement decreased serum and hepatic lipid levels and improved liver injury in CM pigs. Compared to IM and CMT pigs, CM pigs had lower serum levels of superoxide dismutase but higher levels of malondialdehyde. Gene expression analysis revealed that upregulated genes in the livers of CM pigs were mainly enriched for genes mediating immune and inflammatory responses, oxidative stress, and apoptosis. Surprisingly, the downregulated genes mainly included those that regulate metabolism-related processes, including fatty acid oxidation, steroid biosynthesis, cholesterol and bile acid metabolism, and glucose metabolism. KEGG analysis showed that metabolic pathways, fatty acid degradation, pyruvate metabolism, the tricarboxylic acid cycle, and the nuclear factor-kappaB signaling pathway were the major pathways altered in CM pigs.
   Conclusions: This study demonstrated that testosterone deficiency aggravated hypercholesterolemia and hepatic steatosis in pigs fed an HFC diet and that these effects could be reversed by testosterone replacement therapy. Impaired metabolic processes, enhanced immune and inflammatory responses, oxidative stress, and apoptosis may contribute to the increased hepatic steatosis induced by testosterone deficiency and an HFC diet. These results deepened our understanding of the molecular mechanisms of testosterone deficiency-induced hepatic steatosis and provided a foundation for future investigations.
C1 [Cai, Zhaowei; Pan, Yongming; Chen, Liang; Zhu, Keyan; Cai, Yueqin; Ling, Yun; Chen, Fangming; Xu, Xiaoping; Chen, Minli] Zhejiang Chinese Med Univ, Lab Anim Res Ctr, Hangzhou 310053, Zhejiang, Peoples R China.
   [Jiang, Xiaoling] Roswell Pk Canc Inst, Dept Canc Genet, Buffalo, NY 14263 USA.
   [Zhang, Lifan] Nanjing Agr Univ, Coll Anim Sci, Nanjing 310058, Jiangsu, Peoples R China.
C3 Zhejiang Chinese Medical University; Roswell Park Comprehensive Cancer
   Center; Nanjing Agricultural University
RP Chen, ML (corresponding author), Zhejiang Chinese Med Univ, Lab Anim Res Ctr, Hangzhou 310053, Zhejiang, Peoples R China.
EM cml-zjtcm@hotmail.com
RI Zhang, Lifan/HJI-3945-2023; Liu, You-Nian/G-2697-2013; Chen,
   Fang-Ming/D-4721-2009
OI Jiang, Xiaoling/0000-0001-6004-0176; , Lifan/0000-0002-8166-9173; cai,
   zhaowei/0000-0002-0752-1541
FU National Natural Science Foundation of China [31200921]; Zhejiang
   Provincial Natural Science Foundation of China [LQ12C04003, LY12C04002];
   Zhejiang Provincial Department of Science and Technology [2014C37010];
   Fundamental Research Funds for the Central Universities [KYZ201414]
FX This work was supported by grants from the National Natural Science
   Foundation of China (No. 31200921), Zhejiang Provincial Natural Science
   Foundation of China (Nos. LQ12C04003 and LY12C04002), Zhejiang
   Provincial Department of Science and Technology (No. 2014C37010), and
   the Fundamental Research Funds for the Central Universities (KYZ201414).
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NR 94
TC 27
Z9 28
U1 0
U2 35
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1471-2164
J9 BMC GENOMICS
JI BMC Genomics
PD FEB 6
PY 2015
VL 16
AR 59
DI 10.1186/s12864-015-1283-0
PG 19
WC Biotechnology & Applied Microbiology; Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Genetics & Heredity
GA CB0VF
UT WOS:000349345000001
PM 25887406
OA gold, Green Published
DA 2025-06-11
ER

PT S
AU Marques, AH
   Silverman, MN
   Sternberg, EM
AF Marques, Andrea H.
   Silverman, Marni N.
   Sternberg, Esther M.
BE Judd, LL
   Sternberg, EM
TI Glucocorticoid Dysregulations and Their Clinical Correlates From
   Receptors to Therapeutics
SO GLUCOCORTICOIDS AND MOOD CLINICAL MANIFESTATIONS, RISK FACTORS, AND
   MOLECULAR MECHANISMS
SE Annals of the New York Academy of Sciences
LA English
DT Article; Proceedings Paper
CT Conference on Glucocorticoids and Mood - Clinical Manifestations, Risk
   Factors and Molecular Mechanisms
CY JUN 20-21, 2008
CL San Diego, CA
DE cortisol; HPA axis; glucocorticoid resistance; depression; psychosis;
   inflammation; cytokines
ID CORTICOTROPIN-RELEASING HORMONE; CORTICOSTEROID-BINDING GLOBULIN; MAJOR
   DEPRESSIVE DISORDER; RESISTANCE P-GLYCOPROTEIN; STEROID DEMENTIA
   SYNDROME; NECROSIS-FACTOR-ALPHA; FUNCTION IN-VITRO; CUSHINGS-SYNDROME;
   MESSENGER-RNA; HPA AXIS
AB Clinicians have long known that a substantial proportion of patients treated with high-dose glucocorticoids experience a variety of serious side effects, including metabolic syndrome, bone loss, and mood shifts, such as depressive symptomatology, manic or hypomanic symptoms, and even suicide. The reason for individual variability in expression or severity of these side effects is not clear. However, recent emerging literature is beginning to shed light on possible mechanisms of these effects. As an introduction to this volume, this chapter will review the basic biology of glucocorticoid release and molecular mechanisms of glucocorticoid receptor function, and will discuss how dysregulation of glucocorticoid action at all levels could contribute to such side effects. At the molecular level, glucocorticoid receptor polymorphisms may be associated either with receptor hypofunction or hyperfunction and could thus contribute to differential individual sensitivity to the effects of glucocorticoid treatment. Numerous factors regulate hypothalamic-pituitary-adrenal (HPA) axis responsiveness, which could also contribute to individual differences in glucocorticoid side effects. One of these is sex hormone status and the influence of estrogen and progesterone on HPA axis function and mood. Another is immune system activity, in which immune molecules, such as interleukins and cytokines, activate the HPA axis and alter brain function, including memory, cognition, and mood. The effects of cytokines in inducing sickness behaviors, which overlap with depressive symptomatology, could also contribute to individual differences in such symptomatology. Taken together, this knowledge will have important relevance for identifying at-risk patients to avoid or minimize such side effects when they are treated with glucocorticoids. A framework for assessment of patients is proposed that incorporates functional, physiological, and molecular biomarkers to identify subgroups of patients at risk for depressive symptomatology associated with glucocorticoid treatment, and for prevention of side effects, which in many cases can be life-threatening.
C1 [Marques, Andrea H.; Silverman, Marni N.; Sternberg, Esther M.] NIMH, Integrat Neural Immune Program, Sect Neuroendocrine Immunol & Behav, NIH, Rockville, MD 20852 USA.
C3 National Institutes of Health (NIH) - USA; NIH National Institute of
   Mental Health (NIMH)
RP Sternberg, EM (corresponding author), NIMH, Integrat Neural Immune Program, Sect Neuroendocrine Immunol & Behav, NIH, 5625 Fishers Lane,MSC 9401, Rockville, MD 20852 USA.
EM sternbee@mail.nih.gov
RI marques, andrea/H-5297-2012
FU Intramural NIH HHS [ZIA MH002585] Funding Source: Medline
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NR 152
TC 117
Z9 144
U1 0
U2 23
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN STREET, MALDEN 02148, MA USA
SN 0077-8923
BN 978-1-57331-748-1
J9 ANN NY ACAD SCI
JI Ann.NY Acad.Sci.
PY 2009
VL 1179
BP 1
EP 18
DI 10.1111/j.1749-6632.2009.04987.x
PG 18
WC Biochemistry & Molecular Biology
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA BMJ24
UT WOS:000272551200001
PM 19906229
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Kedzierska-Kapuza, K
   Szczuko, U
   Stolinska, H
   Bakaloudi, DR
   Wierzba, W
   Szczuko, M
AF Kedzierska-Kapuza, Karolina
   Szczuko, Urszula
   Stolinska, Hanna
   Bakaloudi, Dimitra Rafailia
   Wierzba, Waldemar
   Szczuko, Malgorzata
TI Demand for Water-Soluble Vitamins in a Group of Patients with CKD versus
   Interventions and Supplementation-A Systematic Review
SO NUTRIENTS
LA English
DT Review
DE chronic kidney disease; vitamins B; vitamin C; vitamin supplementation
ID CHRONIC KIDNEY-DISEASE; RESTLESS LEGS SYNDROME; STAGE RENAL-DISEASE;
   C-REACTIVE PROTEIN; HEMODIALYSIS-PATIENTS; FOLIC-ACID; ASCORBIC-ACID;
   INTERNATIONAL SOCIETY; CONSENSUS STATEMENT; OXIDATIVE STRESS
AB Background: Increasingly, chronic kidney disease (CKD) is becoming an inevitable consequence of obesity, metabolic syndrome, and diabetes. As the disease progresses, and through dialysis, the need for and loss of water-soluble vitamins both increase. This review article looks at the benefits and possible risks of supplementing these vitamins with the treatment of CKD. Methods: Data in the PubMed and Embase databases were analyzed. The keywords "chronic kidney disease", in various combinations, are associated with thiamin, riboflavin, pyridoxine, pantothenic acid, folates, niacin, cobalamin, and vitamin C. This review focuses on the possible use of water-soluble vitamin supplementation to improve pharmacological responses and the overall clinical condition of patients. Results: The mechanism of supportive supplementation is based on reducing oxidative stress, covering the increased demand and losses resulting from the treatment method. In the initial period of failure (G2-G3a), it does not require intervention, but later, especially in the case of inadequate nutrition, the inclusion of supplementation with folate and cobalamin may bring benefits. Such supplementation seems to be a necessity in patients with stage G4 or G5 (uremia). Conversely, the inclusion of additional B6 supplementation to reduce CV risk may be considered. At stage 3b and beyond (stages 4-5), the inclusion of niacin at a dose of 400-1000 mg, depending on the patient's tolerance, is required to lower the phosphate level. The inclusion of supplementation with thiamine and other water-soluble vitamins, especially in peritoneal dialysis and hemodialysis patients, is necessary for reducing dialysis losses. Allowing hemodialysis patients to take low doses of oral vitamin C effectively reduces erythropoietin dose requirements and improves anemia in functional iron-deficient patients. However, it should be considered that doses of B vitamins that are several times higher than the recommended dietary allowance of consumption may exacerbate left ventricular diastolic dysfunction in CKD patients. Conclusions: Taking into account the research conducted so far, it seems that the use of vitamin supplementation in CKD patients may have a positive impact on the treatment process and maintaining a disease-free condition.
C1 [Kedzierska-Kapuza, Karolina; Wierzba, Waldemar] State Med Inst Minist Interior & Adm Warsaw, 137 Woloska St, PL-02507 Warsaw, Poland.
   [Kedzierska-Kapuza, Karolina] Ctr Postgrad Med Educ Warsaw, Dept Gastroenterol Surg & Transplantol, 137 Woloska St, PL-02507 Warsaw, Poland.
   [Szczuko, Urszula; Szczuko, Malgorzata] Pomeranian Med Univ, Dept Human Nutr & Metabol, PL-71460 Szczecin, Poland.
   [Stolinska, Hanna] Love Yourself Hanna Stolinska, 112 Sobieskiego St, PL-00764 Warsaw, Poland.
   [Bakaloudi, Dimitra Rafailia] Aristotle Univ Thessaloniki, Gen Hosp Thessaloniki G Papageorgiou, Dept Med Oncol, Saloniki 54623, Greece.
   [Bakaloudi, Dimitra Rafailia] Univ Washington, Dept Med, Div Oncol, Seattle, WA 98109 USA.
C3 Centre of Postgraduate Medical Education - Poland; Pomeranian Medical
   University; Aristotle University of Thessaloniki; University of
   Washington; University of Washington Seattle
RP Kedzierska-Kapuza, K (corresponding author), State Med Inst Minist Interior & Adm Warsaw, 137 Woloska St, PL-02507 Warsaw, Poland.; Kedzierska-Kapuza, K (corresponding author), Ctr Postgrad Med Educ Warsaw, Dept Gastroenterol Surg & Transplantol, 137 Woloska St, PL-02507 Warsaw, Poland.; Szczuko, M (corresponding author), Pomeranian Med Univ, Dept Human Nutr & Metabol, PL-71460 Szczecin, Poland.
EM karolina.kedzierska@gmail.com; malgorzata.szczuko@pum.edu.pl
RI Bakaloudi, Dimitra Rafailia/GLR-6249-2022; Szczuko,
   Malgorzata/A-9501-2015
OI Szczuko, Malgorzata/0000-0001-9808-0624
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NR 101
TC 13
Z9 13
U1 2
U2 5
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD FEB
PY 2023
VL 15
IS 4
AR 860
DI 10.3390/nu15040860
PG 19
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 9K6DS
UT WOS:000940956600001
PM 36839219
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Laflamme, DP
AF Laflamme, D. P.
TI COMPANION ANIMALS SYMPOSIUM: Obesity in dogs and cats: What is wrong
   with being fat?
SO JOURNAL OF ANIMAL SCIENCE
LA English
DT Article; Proceedings Paper
CT Growth and Development Symposium
CY JUL 10-14, 2011
CL New Orleans, LA
DE adipokine; canine; diabetes; feline; insulin resistance; obesity
ID INDUCED OXIDATIVE STRESS; CONDITION SCORE SYSTEM; HIGH-PROTEIN INTAKE;
   INSULIN-RESISTANCE; WEIGHT-LOSS; ADIPOSE-TISSUE; METABOLIC SYNDROME;
   GLUCOSE-TOLERANCE; BODY-COMPOSITION; FOOD-INTAKE
AB Few diseases in modern pets are diet induced. One possible exception to this is obesity, which is ultimately caused by consuming more calories than needed by the dog or cat. Although fat is the most concentrated and efficiently stored source of calories, and protein least so, an excess of calories from any source will contribute to adiposity. Obesity is an excess of body fat sufficient to result in impairment of health or body function. In people, this is generally recognized as 20 to 25% above ideal BW. This degree of excess is important in dogs as well. A lifelong study in dogs showed that even moderately overweight dogs were at greater risk for earlier morbidity; these dogs required medication for chronic health problems sooner than their lean-fed siblings. The average difference in BW between groups was approximately 25%. Obese cats also face increased health risks, including an increased risk of arthritis, diabetes mellitus, hepatic lipidosis, and early mortality. The risk for development of diabetes increases about 2-fold in overweight cats and about 8-fold in obese cats. Altered adipokine secretion appears to be an important mechanism for the link between excess BW and many diseases. Once considered to be physiologically inert, adipose tissue is an active producer of hormones, such as leptin and resistin, and cytokines, including many inflammatory cytokines such as tumor necrosis factor-alpha, IL-1 beta and IL-6, and C-reactive protein. The persistent, low-grade inflammation secondary to obesity is thought to play a causal role in chronic diseases such as osteoarthritis, cardiovascular disease, diabetes mellitus, and others. For example, tumor necrosis factor-alpha alters insulin sensitivity by blocking activation of insulin receptors. In addition, obesity is associated with increased oxidative stress, which also may contribute to obesity-related diseases. Management of obesity involves nutritional modification as well as behavioral modification. Increased protein intake combined with reduced calorie intake facilitates loss of body fat while minimizing loss of lean body mass. Limiting treats to 10% of calorie intake and increasing exercise both aid in successful BW management.
C1 Nestle Purina PetCare Res, St Louis, MO 63164 USA.
RP Laflamme, DP (corresponding author), Nestle Purina PetCare Res, Checkerboard Sq 2S, St Louis, MO 63164 USA.
EM dorothy.laflamme@rd.nestle.com
FU Hill's Science Diet (Topeka, KS); Proctor & Gamble (Cincinnati, OH);
   Purina (St. Louis, MO); American Society of Animal Science
FX Based on a presentation at the Companion Animals Symposium titled
   "Living Beyond 20: Discoveries in Geriatric Companion Animal Biology" at
   the Joint Annual Meeting, July 10 to 14, 2011, New Orleans, Louisiana.
   The symposium was sponsored, in part, by Hill's Science Diet (Topeka,
   KS), Proctor & Gamble (Cincinnati, OH), and Purina (St. Louis, MO) with
   publication sponsored by the Journal of Animal Science and the American
   Society of Animal Science.
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NR 128
TC 93
Z9 99
U1 3
U2 207
PU AMER SOC ANIMAL SCIENCE
PI CHAMPAIGN
PA PO BOX 7410, CHAMPAIGN, IL 61826-7410 USA
SN 0021-8812
EI 1525-3163
J9 J ANIM SCI
JI J. Anim. Sci.
PD MAY
PY 2012
VL 90
IS 5
BP 1653
EP 1662
DI 10.2527/jas.2011-4571
PG 10
WC Agriculture, Dairy & Animal Science
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Agriculture
GA 940HI
UT WOS:000303880200029
PM 21984724
DA 2025-06-11
ER

PT J
AU Fehsel, K
AF Fehsel, Karin
TI Why Is Iron Deficiency/Anemia Linked to Alzheimer's Disease and Its
   Comorbidities, and How Is It Prevented?
SO BIOMEDICINES
LA English
DT Review
DE glucose transporter; insulin resistance; HIF1 alpha; hydrogen sulfide;
   metabolic syndrome; ferritin; gingko biloba; COVID-19
ID AMYLOID PRECURSOR PROTEIN; GLUCOSE-METABOLISM; HEART-FAILURE;
   MOLECULAR-MECHANISMS; POSSIBLE INVOLVEMENT; PARKINSONS-DISEASE;
   TRANSPORT ACTIVITY; APOLIPOPROTEIN-E; DNA METHYLATION; GENE-EXPRESSION
AB Impaired iron metabolism has been increasingly observed in many diseases, but a deeper, mechanistic understanding of the cellular impact of altered iron metabolism is still lacking. In addition, deficits in neuronal energy metabolism due to reduced glucose import were described for Alzheimer's disease (AD) and its comorbidities like obesity, depression, cardiovascular disease, and type 2 diabetes mellitus. The aim of this review is to present the molecular link between both observations. Insufficient cellular glucose uptake triggers increased ferritin expression, leading to depletion of the cellular free iron pool and stabilization of the hypoxia-induced factor (HIF) 1 alpha. This transcription factor induces the expression of the glucose transporters (Glut) 1 and 3 and shifts the cellular metabolism towards glycolysis. If this first line of defense is not adequate for sufficient glucose supply, further reduction of the intracellular iron pool affects the enzymes of the mitochondrial electron transport chain and activates the AMP-activated kinase (AMPK). This enzyme triggers the translocation of Glut4 to the plasma membrane as well as the autophagic recycling of cell components in order to mobilize energy resources. Moreover, AMPK activates the autophagic process of ferritinophagy, which provides free iron urgently needed as a cofactor for the synthesis of heme- and iron-sulfur proteins. Excessive activation of this pathway ends in ferroptosis, a special iron-dependent form of cell death, while hampered AMPK activation steadily reduces the iron pools, leading to hypoferremia with iron sequestration in the spleen and liver. Long-lasting iron depletion affects erythropoiesis and results in anemia of chronic disease, a common condition in patients with AD and its comorbidities. Instead of iron supplementation, drugs, diet, or phytochemicals that improve energy supply and cellular glucose uptake should be administered to counteract hypoferremia and anemia of chronic disease.
C1 [Fehsel, Karin] Heinrich Heine Univ, Med Fac, Dept Psychiat, Neurobiochem Res Unit, D-240629 Dusseldorf, Germany.
C3 Heinrich Heine University Dusseldorf
RP Fehsel, K (corresponding author), Heinrich Heine Univ, Med Fac, Dept Psychiat, Neurobiochem Res Unit, D-240629 Dusseldorf, Germany.
EM fehsel@uni-duesseldorf.de
OI Fehsel, Karin/0000-0003-3165-4464
FU Program of National Beef Cattle and Yak Industrial Technology System
   [CARS-37]; Agricultural Science and Technology Innovation Program in the
   Chinese Academy of Agricultural Sciences [ASTIP-IAS03]; Government
   Purchase Service Project of the Ministry of Agriculture and Rural
   Affairs [19200158]
FX This study was financially supported by the Program of National Beef
   Cattle and Yak Industrial Technology System [CARS-37], Agricultural
   Science and Technology Innovation Program in the Chinese Academy of
   Agricultural Sciences [ASTIP-IAS03] and Government Purchase Service
   Project of the Ministry of Agriculture and Rural Affairs [19200158]
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NR 229
TC 7
Z9 7
U1 4
U2 16
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2227-9059
J9 BIOMEDICINES
JI Biomedicines
PD SEP
PY 2023
VL 11
IS 9
AR 2421
DI 10.3390/biomedicines11092421
PG 24
WC Biochemistry & Molecular Biology; Medicine, Research & Experimental;
   Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Research & Experimental Medicine;
   Pharmacology & Pharmacy
GA T1NV6
UT WOS:001075731800001
PM 37760862
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Yang, QH
   Durmer, JL
   Wheaton, AG
   Jackson, SL
   Zhang, ZF
AF Yang, Quanhe
   Durmer, Julia L.
   Wheaton, Anne G.
   Jackson, Sandra L.
   Zhang, Zefeng
TI Sleep duration and excess heart age among US adults
SO SLEEP HEALTH
LA English
DT Article
DE Sleep duration; Heart age; Cardiovascular disease; Risk factors
ID CARDIOVASCULAR-DISEASE RISK; BODY-MASS INDEX; METABOLIC SYNDROME;
   SOCIOECONOMIC-STATUS; SOCIAL JETLAG; ASSOCIATION; HYPERTENSION;
   MORTALITY; HEALTH; IMPACT
AB Objectives: Insufficient sleep negatively impacts the cardiovascular system. No study has examined the association between sleep duration and heart age (person's predicted vascular age based on cardiovascular disease [CVD] risk profile). This study examines association between sleep duration and excess heart age (EHA; difference between heart age and chronological age) among US adults.
   Design and participants: Cross-sectional 2007-2014 National Health and Nutrition Examination Survey data for respondents aged 30-74 years without CVD or stroke (n= 12,775).
   Measurements: Self-reported sleep duration was classified into 5 categories (<= 5, 6, 7, 8, and >= 9 hours). We used sex-specific Framingham heart age algorithm to calculate heart age and multivariable linear regression to examine association between sleep duration and EHA.
   Results: A total of 13.4% (95% confidence interval 12.5-14.3), 24.2% (23.1-25.2), 31.0% (29.8-32.3), 25.9% (25.0-26.9), and 5.5% (5.0-6.1) reported sleeping <= 5, 6, 7, 8, and >= 9 hours, respectively. We observed a nonlinear relationship between sleep duration and EHA using 7 hours as reference: EHA (adjusted for sociodemographics, body mass index, physical activity, Healthy Eating Index-2010, sleep disorder, and depression status) was 5.1 (4.8-5.8), 4.5 (3.9-5.1), 3.7 (3.3-4.0), 4.5 (4.1-5.0), and 4.1 (3.3-4.9) years for sleep durations of <= 5, 6, 7, 8 and >= 9 hours, respectively (P =.015 for quadratic trend). EHA was significantly higher among participants with lower education, lower income, and obesity.
   Conclusion: Mean adjusted EHA was lowest among adults who reported sleeping 7 hours per night and increased as adults reported sleeping fewer or more hours. Discussing sleep duration in the context of EHA may be helpful for patients and clinicians. (c) 2018 National Sleep Foundation. Published by Elsevier Inc. All rights reserved.
C1 [Yang, Quanhe; Jackson, Sandra L.; Zhang, Zefeng] Ctr Dis Control & Prevent, Div Heart Dis & Stroke Prevent, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA USA.
   [Durmer, Julia L.] Emory Univ, Coll Arts & Sci, Atlanta, GA 30322 USA.
   [Wheaton, Anne G.] Ctr Dis Control & Prevent, Div Populat Hlth, Natl Ctr Chron Dis Prevent & Hlth Promot, Atlanta, GA USA.
C3 Centers for Disease Control & Prevention - USA; Emory University;
   Centers for Disease Control & Prevention - USA
RP Yang, QH (corresponding author), Ctr Dis Control & Prevent, Div Heart Dis & Stroke Prevent, 4770 Buford Hwy,MailStop F-77, Atlanta, GA 30341 USA.
EM qay0@cdc.gov
OI Wheaton, Anne/0000-0002-3181-9612
FU Division for Heart Disease and Stroke Prevention, Centers for Disease
   Control and Prevention
FX We thank Robert Merritt, Division for Heart Disease and Stroke
   Prevention, Centers for Disease Control and Prevention, for his helpful
   comments and support of the project. We thank Dr Jeff Durmer, Fusion
   Health, for his insight and suggestions.
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NR 59
TC 5
Z9 5
U1 1
U2 8
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2352-7218
EI 2352-7226
J9 SLEEP HEALTH
JI Sleep Health
PD OCT
PY 2018
VL 4
IS 5
BP 448
EP 455
DI 10.1016/j.sleh.2018.07.001
PG 8
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA GU0FO
UT WOS:000444924900011
PM 30241660
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Poole-Wright, K
   Patel, A
   Gaughran, F
   Murray, R
   Chalder, T
AF Poole-Wright, Kim
   Patel, Aakash
   Gaughran, Fiona
   Murray, Robin
   Chalder, Trudie
TI Prevalence and associations of fatigue in psychosis: A systematic review
   and meta-analysis
SO SCHIZOPHRENIA RESEARCH
LA English
DT Article
DE Fatigue; Psychosis; Schizophrenia; Systematic review; Meta-analysis
ID QUALITY-OF-LIFE; DOUBLE-BLIND; LONG-TERM; SCHIZOPHRENIA-PATIENTS;
   METABOLIC SYNDROME; PHYSICAL-ACTIVITY; OPEN-LABEL; TOLERABILITY;
   PLACEBO; EFFICACY
AB Background: There is increasing interest in fatigue in people with psychotic illnesses. This systematic review and meta-analysis reviewed the evidence concerning the prevalence of fatigue and associated factors in adults with psychotic illnesses. Methods: Embase, PsycINFO, Medline and CINAHL were systematically searched for articles in English published between January 1946 to 9 October 2023. Inclusion criteria was 'fatigue' in adults (>= 18 years old) with a confirmed ICD11 or DSM5 diagnosis of a psychotic disorder. Risk of bias was assessed with the JBI and the Newcastle-Ottawa Scale. Pooled proportions for fatigue with 95 % CI were calculated using random effects models. Heterogeneity was assessed using Cochran's Q and I2 statistic and Egger's tests were conducted for publication bias. Results: A total of 57 articles met the inclusion criteria and 7 articles (n = 1161 participants) were included for the meta-analysis of fatigue. Fatigue prevalence was 55 % (95 % CI: 37-71 %, I2 = 94 %). A sensitivity analysis of the 6 studies using a valid scale (n = 711 participants) found a fatigue proportion of 59 % (95 % CI: 41-76, I2 = 93 %). Eighteen studies (n = 4569 participants) were included for an analysis exploring the prevalence of antipsychotic-related fatigue, which was 20.5 % (95 % CI: 11-34 %). We found no significant difference in antipsychotic-related fatigue between studies using a valid scale (27 %, 95 % CI: 14-46, k = 7) and studies using a clinical interview (17 %, 95 % CI: 7-35 %, k = 11) p = 0.302. An Egger's test indicated no publication bias. Quality assessments for included studies revealed that 16 % were at low risk of bias, 9 % at high risk and 75 % at moderate risk. Reported associations with fatigue included sex, age, antipsychotics, distress and depression, sleep, and some negative symptoms. Conclusions: Our study revealed that a majority of people with psychosis experience fatigue. Antipsychotics, sex, and functioning may contribute to tiredness symptoms, but further research is needed.
C1 [Poole-Wright, Kim; Chalder, Trudie] Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Psychol Med, 16 De Crespigny Pk, London SE5 8AB, England.
   [Patel, Aakash] Kings Coll London, Inst Psychiat Psychol & Neurosci, 16 De Crespigny Pk, London SE5 8AB, England.
   [Gaughran, Fiona] South London & Maudsley NHS Fdn Trust, Natl Psychosis Unit, 16 De Crespigny Pk, London SE5 8AB, England.
   [Gaughran, Fiona] Kings Coll London, Inst Psychiat Psychol & Neurosci, 16 De Crespigny Pk, London SE5 8AB, England.
   [Murray, Robin] Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Psychosis Studies, 16 De Crespigny Pk, London SE5 8AB, England.
C3 University of London; King's College London; University of London;
   King's College London; South London & Maudsley NHS Trust; University of
   London; King's College London; University of London; King's College
   London
RP Chalder, T (corresponding author), Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Psychol Med, 16 De Crespigny Pk, London SE5 8AB, England.
EM Trudie.chalder@kcl.ac.uk
RI Gaughran, Fiona/AAC-7160-2019; murray, robin/F-8658-2012
OI Chalder, Trudie/0000-0003-0775-1045; murray, robin/0000-0003-0829-0519
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NR 113
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0920-9964
EI 1573-2509
J9 SCHIZOPHR RES
JI Schizophr. Res.
PD MAY
PY 2025
VL 279
BP 59
EP 70
DI 10.1016/j.schres.2025.03.027
EA APR 2025
PG 12
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 1BB7A
UT WOS:001460787600001
PM 40174485
OA hybrid
DA 2025-06-11
ER

PT J
AU Choi, H
   Lim, JY
   Lim, NK
   Ryu, HM
   Kwak, DW
   Chung, JH
   Park, HJ
   Park, HY
AF Choi, Hansol
   Lim, Joong-Yeon
   Lim, Nam-Kyoo
   Ryu, Hyun Mee
   Kwak, Dong Wook
   Chung, Jin Hoon
   Park, Hee Jin
   Park, Hyun-Young
TI Impact of pre-pregnancy body mass index and gestational weight gain on
   the risk of maternal and infant pregnancy complications in Korean women
SO INTERNATIONAL JOURNAL OF OBESITY
LA English
DT Article
ID METABOLIC SYNDROME; SMOKING-CESSATION; OBESE WOMEN; OUTCOMES;
   ASSOCIATION; PREVALENCE; CLASSIFICATION; HYPERGLYCEMIA; DEPRESSION;
   ADIPOSITY
AB Background/Objective Healthy weight maintenance before and during pregnancy has a significant effect on pregnancy outcomes; however, there are no specific guidelines for gestational weight gain in pregnant Korean women. Therefore, we investigated the impact of pre-pregnancy body mass index (BMI) and gestational weight gain on the risk of maternal and infant pregnancy complications in pregnant Korean women. Methods Study participants comprised 3454 singleton pregnant women from the Korean Pregnancy Outcome Study who had baseline examination and pregnancy outcome data. Maternal pre-pregnancy BMI and gestational weight gain were categorized according to the Asia-pacific regional guidelines and the Institute of Medicine recommendations, respectively. The primary outcome was any adverse outcomes, defined as the presence of one or more of the following: hypertensive disorders of pregnancy, gestational diabetes mellitus, peripartum depressive symptom, cesarean delivery, delivery complications, preterm birth, small or large weight infant, neonatal intensive care unit admission, or a congenital anomaly. Multiple logistic regression models were applied to examine the independent and combined impact of pre-pregnancy BMI and gestational weight gain on the risk of maternal and infant outcomes. Results Obesity before pregnancy significantly increased the risk of perinatal adverse outcomes by more than 2.5 times [odds ratio (OR): 2.512, 95% confidence interval (CI): 1.817-3.473]. Compared to that in women with appropriate gestational weight gain, women with excessive weight gain had a 36.4% incremental increase in the risk of any adverse outcomes [OR: 1.364, 95% CI: 1.115-1.670]. Moreover, women who were overweight or obese before pregnancy and had excessive gestational weight gain had a three-fold increase in the risk of adverse outcomes [OR: 3.460, 95% CI: 2.210-5.417]. Conclusion This study highlights the need for appropriate weight recommendations before and during pregnancy to prevent perinatal complications in Korean women of childbearing age.
C1 [Choi, Hansol; Lim, Nam-Kyoo] Korea Natl Inst Hlth, Korea Dis Control & Prevent Agcy, Div Populat Res, Dept Precis Med, Cheongju, South Korea.
   [Lim, Joong-Yeon] Minist Hlth & Welf, Bur Adv Hlth Technol Policy, Div Healthcare Technol Dev, Sejong, South Korea.
   [Ryu, Hyun Mee] CHA Univ Sch Med, Dept Obstet & Gynecol, CHA Bundang Med Ctr, Seongnam, South Korea.
   [Kwak, Dong Wook] Ajou Univ, Sch Med, Dept Obstet & Gyneco, Suwon, South Korea.
   [Chung, Jin Hoon] Univ Ulsan, Sch Med, Asan Med Ctr, Dept Obstet & Gynecol, Seoul, South Korea.
   [Park, Hee Jin] CHA Univ Sch Med, CHA Gangnam Med Ctr, Department Obstet & Gynecol, Seoul, South Korea.
   [Park, Hyun-Young] Korea Natl Inst Hlth, Korea Dis Control & Prevent Agcy, Dept Precis Med, Cheongju, South Korea.
C3 Korea Disease Control & Prevention Agency (KDCA); Korea National
   Institute of Health (KNIH); Pochon Cha University; Ajou University;
   University of Ulsan; Asan Medical Center; Korea Disease Control &
   Prevention Agency (KDCA); Korea National Institute of Health (KNIH)
RP Park, HY (corresponding author), Korea Natl Inst Hlth, Korea Dis Control & Prevent Agcy, Dept Precis Med, Cheongju, South Korea.
EM hypark65@korea.kr
RI Choi, Hansol/KEI-6053-2024
OI Park, Hyun-Young/0000-0002-6698-7368
FU National Institute of Health, Korea Centers for Disease Control and
   Prevention [2018-NG001-00]
FX This research was supported by the National Institute of Health, Korea
   Centers for Disease Control and Prevention (Grant No: 2018-NG001-00).
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NR 53
TC 23
Z9 26
U1 0
U2 12
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0307-0565
EI 1476-5497
J9 INT J OBESITY
JI Int. J. Obes.
PD JAN
PY 2022
VL 46
IS 1
BP 59
EP 67
DI 10.1038/s41366-021-00946-8
EA SEP 2021
PG 9
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA YE3GJ
UT WOS:000692967200001
PM 34489525
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Scarlata, S
   Pedone, C
   Fimognari, FL
   Bellia, V
   Forastiere, F
   Incalzi, RA
AF Scarlata, Simone
   Pedone, Claudio
   Fimognari, Filippo L.
   Bellia, Vincenzo
   Forastiere, Francesco
   Incalzi, Raffaele Antonelli
TI Restrictive pulmonary dysfunction at spirometry and mortality in the
   elderly
SO RESPIRATORY MEDICINE
LA English
DT Article
DE lung restriction; pulmonary function tests; elderly; longitudinal
   studies; mortality
ID NUTRITION EXAMINATION SURVEY; LUNG-FUNCTION DECLINE; 1ST
   NATIONAL-HEALTH; METABOLIC SYNDROME; PREVALENCE; ASSOCIATION; OUTCOMES;
   DISEASE; ASTHMA; STATE
AB Objectives: To evaluate the association between pulmonary restriction and mortality in the elderly, taking into account potential confounders not considered in the past (disability, cognitive dysfunction, diabetes, and visceral obesity).
   Design: Longitudinal study.
   Setting: Community-based.
   Participants: Twelve hundred sixty-five patients (51.9% men) aged 65-97 years old from the Salute Respiratoria nell'Anziano (SaRA) Italian multicentric study. Measurements: Participants were divided in 4 groups: normal spirometry (NS): FEV1/FVC >= 70%, FVC >= 80% of predicted; restrictive ventilatory pattern (RVP): FEV1/FVC >= 70%, FVC < 80%; obstructive ventilatory pattern (OVP): FEV1/FVC >= 70%, FVC >= 80%, and mixed ventilatory pattern (MVP): FEV1/FVC < 70%, FVC >= 80%. We calculated the association between restriction and mortality corrected for potential confounders using a multivariable Cox regression model.
   Results: We found a prevalence of RVP, OVP and MVP of 10.9%, 25.4%, and 17.3%, respectively. Compared to people with normal spirometric pattern, disability (19.6% vs. 10.1%), poor physical performance (35.4% vs. 22.3%), cognitive impairment (21.0% vs. 11.5%), increased waist circumference (62.1% and 26.8%), and kyphoscoliosis (56.8 and 13.5%) were more prevalent in the RVP group. After correction for potential confounders, RVP was associated with increased mortality (HR: 1.89; 95% CI: 1.15-3.11), as well as OVP (HR: 2.33; 95% CI: 1.58-3.11) and MVP (HR: 2.60; 95% CI: 1.74-3.93). Other factors associated with mortality were disability (HR: 1.92; 95% CI: 1.35-2.72), poor physical performance (HR: 1.37; 95% CI: 1.01-1.85), cognitive impairment (HR: 1.55; 95% CI: 1.06-2.27), depression (HR: 1.57; 95% CI: 1.16-2.13) and diagnosis of stroke (HR: 1.90; 95% CI: 1.18-3.05).
   Conclusions: RVP is associated with higher mortality in the elderly and, thus, deserves the same attention paid to an obstructive pattern. However, mechanisms mediating this association need to be clarified. (C) 2008 Elsevier Ltd. All rights reserved.
C1 [Scarlata, Simone; Pedone, Claudio; Fimognari, Filippo L.; Incalzi, Raffaele Antonelli] Univ Campus Biomed, Chair Geriatr, I-00128 Rome, Italy.
   [Fimognari, Filippo L.] Osped Parodi Delfino, Div Internal Med, Unit Resp Physiopathol, Rome, Italy.
   [Bellia, Vincenzo] Univ Palermo, Inst Gen Med & Pneumol, Palermo, Italy.
   [Forastiere, Francesco] Roma E Hlth Author, Dept Epidemiol, Rome, Italy.
   [Incalzi, Raffaele Antonelli] San Raffaele Fdn, Taranto, Italy.
C3 University Campus Bio-Medico - Rome Italy; University of Palermo
RP Pedone, C (corresponding author), Univ Campus Biomed, Chair Geriatr, Via Compositori 130, I-00128 Rome, Italy.
EM s.scarlata@unicampus.it; c.pedone@unicampus.it
RI Pedone, Claudio/F-9488-2010; Scarlata, Simone/G-6490-2010; Fimognari,
   Filippo/HJA-3439-2022; Forastiere, Francesco/J-9067-2016
OI Pedone, Claudio/0000-0003-1847-9032; Antonelli Incalzi,
   Raffaele/0000-0003-2100-2075; Forastiere, Francesco/0000-0002-9162-5684
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NR 24
TC 73
Z9 75
U1 0
U2 7
PU W B SAUNDERS CO LTD
PI LONDON
PA 32 JAMESTOWN RD, LONDON NW1 7BY, ENGLAND
SN 0954-6111
EI 1532-3064
J9 RESP MED
JI Respir. Med.
PD SEP
PY 2008
VL 102
IS 9
BP 1349
EP 1354
DI 10.1016/j.rmed.2008.02.021
PG 6
WC Cardiac & Cardiovascular Systems; Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System
GA 345XO
UT WOS:000259031300018
PM 18599282
DA 2025-06-11
ER

PT J
AU Marcus, R
   Khan, A
   Rollin, L
   Morris, B
   Timko, K
   Carson, W
   Sanchez, R
AF Marcus, Ronald
   Khan, Arif
   Rollin, Linda
   Morris, Beth
   Timko, Karen
   Carson, William
   Sanchez, Raymond
TI Efficacy of aripiprazole adjunctive to lithium or valproate in the
   long-term treatment of patients with bipolar I disorder with an
   inadequate response to lithium or valproate monotherapy: a multicenter,
   double-blind, randomized study
SO BIPOLAR DISORDERS
LA English
DT Article
DE aripiprazole; bipolar disorder; efficacy; safety
ID CONTROLLED 18-MONTH TRIAL; MAINTENANCE TREATMENT; METABOLIC SYNDROME;
   MOOD STABILIZER; PARTIAL AGONIST; RATING-SCALE; UPDATE 2009; PLACEBO;
   MANIA; DIVALPROEX
AB Objectives:
   To evaluate the efficacy and safety of aripiprazole (ARI) adjunctive to lithium (Li) or valproate (Val) (ARI + Li / Val) compared with placebo (PLB) adjunctive to Li or Val (PLB + Li / Val) as maintenance therapy for patients with bipolar I disorder who had an inadequate response to Li or Val monotherapy.
   Methods:
   Patients with a current manic/mixed episode received Li or Val for at least 2 weeks. Those with an inadequate response [Young Mania Rating Scale (YMRS) total score >= 16 and < 35% decrease from baseline at 2 weeks] received adjunctive single-blind ARI plus mood stabilizer. Patients who achieved stability [YMRS and Montgomery-Asberg Depression Rating Scale (MADRS) score < 12] for 12 consecutive weeks were randomized to double-blind ARI (10-30 mg/day) or PLB + Li / Val. Relapse was monitored for 52 weeks. Adverse events (AEs) were also evaluated.
   Results:
   A total of 337 patients were randomized to ARI + Li / Val (n = 168) or PLB + Li / Val (n = 169). The Kaplan-Meier relapse rate at 52 weeks was 17% with ARI + Li / Val and 29% with PLB + Li / Val. ARI + Li / Val significantly delayed time to any relapse compared with PLB + Li / Val; hazard ratio = 0.54 (95% confidence interval: 0.33-0.89; log-rank p = 0.014). The most common AEs >= 5% (ARI + Li / Val versus PLB + Li / Val) were headache (13.2% versus 10.8%), weight increase (9.0% versus 6.6%), tremor (6.0% versus 2.4%), and insomnia (5.4% versus 9.6%).
   Conclusions:
   Continuation of ARI + Li / Val treatment increased the time to relapse to any mood episode compared with Li or Val monotherapy, and was relatively well tolerated during the one-year study. These findings suggest that there is a long-term benefit in continuing ARI adjunctive to a mood stabilizer after sustained remission is achieved.
C1 [Marcus, Ronald; Rollin, Linda; Morris, Beth; Timko, Karen] Bristol Myers Squibb Co, Wallingford, CT 06492 USA.
   [Khan, Arif] NW Clin Res Ctr, Bellevue, WA USA.
   [Khan, Arif] Duke Univ, Dept Psychiat & Behav Sci, Durham, NC USA.
   [Carson, William; Sanchez, Raymond] Otsuka Pharmaceut Dev & Commercializat Inc, Princeton, NJ USA.
C3 Bristol-Myers Squibb; Duke University; Otsuka Pharmaceutical
RP Marcus, R (corresponding author), Bristol Myers Squibb Co, 5 Res Pkwy, Wallingford, CT 06492 USA.
EM ronald.marcus@bms.com
RI khan, Arif/HMV-3165-2023
FU Bristol-Myers Squibb (Princeton, NJ, USA); Otsuka Pharmaceutical Co.,
   Ltd. (Tokyo, Japan); Bristol-Myers Squibb
FX This study was supported by Bristol-Myers Squibb (Princeton, NJ, USA)
   and Otsuka Pharmaceutical Co., Ltd. (Tokyo, Japan). Editorial support
   for the preparation of this manuscript was provided by Ogilvy
   Healthworld Medical Education; funding was provided by Bristol-Myers
   Squibb.
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NR 33
TC 93
Z9 94
U1 0
U2 10
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1398-5647
J9 BIPOLAR DISORD
JI Bipolar Disord.
PD MAR
PY 2011
VL 13
IS 2
BP 133
EP 144
DI 10.1111/j.1399-5618.2011.00898.x
PG 12
WC Clinical Neurology; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Psychiatry
GA 741KV
UT WOS:000288863500002
PM 21443567
DA 2025-06-11
ER

PT J
AU Govindsamy, A
   Ghoor, S
   Cerf, ME
AF Govindsamy, Annelene
   Ghoor, Samira
   Cerf, Marlon E.
TI Programming With Varying Dietary Fat Content Alters Cardiac Insulin
   Receptor, Glut4 and FoxO1 Immunoreactivity in Neonatal Rats, Whereas
   High Fat Programming Alters Cebpa Gene Expression in Neonatal Female
   Rats
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Article
DE diabetes; fetal programming; insulin resistance; insulin signaling;
   metabolic syndrome; nutrition; obesity
ID PROTEIN-KINASE-C; SPONTANEOUSLY HYPERTENSIVE-RATS; ISLET-CELL RESPONSE;
   MATERNAL OBESITY; BLOOD-PRESSURE; GLUCOSE TRANSPORTERS;
   SEXUAL-DIMORPHISM; SUSCEPTIBILITY LOCUS; DIABETIC PREGNANCY; INDUCED
   ACTIVATION
AB Fetal programming refers to an intrauterine stimulus or insult that shapes growth, development and health outcomes. Dependent on the quality and quantity, dietary fats can be beneficial or detrimental for the growth of the fetus and can alter insulin signaling by regulating the expression of key factors. The effects of varying dietary fat content on the expression profiles of factors in the neonatal female and male rat heart were investigated and analyzed in control (10% fat), 20F (20% fat), 30F (30% fat) and 40F (40% fat which was a high fat diet used to induce high fat programming) neonatal rats. The whole neonatal heart was immunostained for insulin receptor, glucose transporter 4 (Glut4) and forkhead box protein 1 (FoxO1), followed by image analysis. The expression of 84 genes, commonly associated with the insulin signaling pathway, were then examined in 40F female and 40F male offspring. Maintenance on diets, varying in fat content during fetal life, altered the expression of cardiac factors, with changes induced from 20% fat in female neonates, but from 30% fat in male neonates. Further, CCAAT/enhancer-binding protein alpha (Cebpa) was upregulated in 40F female neonates. There was, however, differential expression of several insulin signaling genes in 40F (high fat programmed) offspring, with some tending to significance but most differences were in fold changes (>= 1.5 fold). The increased immunoreactivity for insulin receptor, Glut4 and FoxO1 in 20F female and 30F male neonatal rats may reflect a compensatory response to programming to maintain cardiac physiology. Cebpa was upregulated in female offspring maintained on a high fat diet, with fold increases in other insulin signaling genes viz. Aebp1, Cfd (adipsin), Adra1d, Prkcg, Igfbp, Retn (resistin) and Ucp1. In female offspring maintained on a high fat diet, increased Cebpa gene expression (concomitant with fold increases in other insulin signaling genes) may reflect cardiac stress and an adaptative response to cardiac inflammation, stress and/or injury, after high fat programming. Diet and the sex are determinants of cardiac physiology and pathophysiology, reflecting divergent mechanisms that are sex-specific.
C1 [Govindsamy, Annelene] Univ KwaZulu Natal, Discipline Pharmaceut Sci, Durban, South Africa.
   [Ghoor, Samira; Cerf, Marlon E.] South African Med Res Council, Biomed Res & Innovat Platform, Cape Town, South Africa.
   [Cerf, Marlon E.] South African Med Res Council, Grants Innovat & Product Dev, Cape Town, South Africa.
C3 University of Kwazulu Natal; South African Medical Research Council;
   South African Medical Research Council
RP Cerf, ME (corresponding author), South African Med Res Council, Biomed Res & Innovat Platform, Cape Town, South Africa.; Cerf, ME (corresponding author), South African Med Res Council, Grants Innovat & Product Dev, Cape Town, South Africa.
EM marlon.cerf@mrc.ac.za
FU South African Medical Research Council (SAMRC) under the Masters/PhD
   Internship scholarship programme; College of Health Sciences, University
   of KwaZulu-Natal (UKZN); National Research Foundation (South Africa)
FX This study was funded by the South African Medical Research Council
   (SAMRC) under the Masters/PhD Internship scholarship programme, the
   College of Health Sciences, University of KwaZulu-Natal (UKZN) and the
   National Research Foundation (South Africa).
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NR 106
TC 4
Z9 4
U1 0
U2 3
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD JAN 5
PY 2022
VL 12
AR 772095
DI 10.3389/fendo.2021.772095
PG 14
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA YL3FU
UT WOS:000745781200001
PM 35069436
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Scheijen, JLJM
   Hanssen, NMJ
   van Greevenbroek, MM
   van der Kallen, CJ
   Feskens, EJM
   Stehouwer, CDA
   Schalkwijk, CG
AF Scheijen, Jean L. J. M.
   Hanssen, Nordin M. J.
   van Greevenbroek, Marleen M.
   van der Kallen, Carla J.
   Feskens, Edith J. M.
   Stehouwer, Coen D. A.
   Schalkwijk, Casper G.
TI Dietary intake of advanced glycation endproducts is associated with
   higher levels of advanced glycation endproducts in plasma and urine: The
   CODAM study
SO CLINICAL NUTRITION
LA English
DT Article
DE Advanced glycation endproducts; Ultra-performance liquid chromatography;
   tandem mass spectrometry; Food frequency questionnaire; Diet; Maillard
   reaction
ID HEALTHY OVERWEIGHT INDIVIDUALS; END-PRODUCTS INCREASES; ENDOTHELIAL
   FUNCTION; METABOLIC SYNDROME; DIABETES-MELLITUS; OXIDATIVE STRESS; RISK;
   FOOD; AGE; QUANTIFICATION
AB Background & aims: Advanced glycation endproducts (AGEs) are formed by the reaction between reducing sugars and proteins. AGEs in the body have been associated with several age-related diseases. High-heat treated and most processed foods are rich in AGEs. The aim of our study was to investigate whether dietary AGEs, are associated with plasma and urinary AGE levels.
   Methods: In 450 participants of the Cohort on Diabetes and Atherosclerosis Maastricht study (CODAM study) we measured plasma and urine concentrations of the AGEs N epsilon-(carboxymethyl)lysine (CML), N epsilon-(1-carboxyethyl)lysine (CEL) and N delta-(5-hydro-5-methyl-4-imidazolon-2-y1)-ornithine (MG-H1) using UPLC-MS/MS. We also estimated dietary intake of CML, CEL and MG-H1 with the use of a dietary AGE database and a food frequency questionnaire (FFQ). We used linear regression to investigate the association between standardized dietary AGE intake and standardized plasma or urinary AGE levels, after adjustment for age, sex, glucose metabolism status, waist circumference, kidney function, energy- and macro-nutrient intake, smoking status, physical activity, alcohol intake, LDL-cholesterol and markers of oxidative stress.
   Results: We found that higher intake of dietary CML, CEL and MG-H1 was associated with significantly higher levels of free plasma and urinary CML, CEL and MG-H1 (beta CML = 0.253 (95% CI 0.086; 0.415), beta CEL = 0.194 (95% CI 0.040; 0.339), beta MG-H1 = 0.223 (95% CI 0.069; 0.373) for plasma and pan = 0.223 (95% CI 0.049; 0.393), beta CEL = 0.180 (95% CI 0.019; 0.332), beta MG-H1 = 0.196 (95% CI 0.037; 0.349) for urine, respectively). In addition, we observed non-significant associations of dietary AGEs with their corresponding protein bound plasma AGEs.
   Conclusion: We demonstrate that higher intake of dietary AGEs is associated with higher levels of AGEs in plasma and urine. Our findings may have important implications for those who ingest a diet rich in AGEs. (C) 2017 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.
C1 [Scheijen, Jean L. J. M.; Hanssen, Nordin M. J.; van Greevenbroek, Marleen M.; van der Kallen, Carla J.; Stehouwer, Coen D. A.; Schalkwijk, Casper G.] Maastricht Univ, Lab Metab & Vasc Med, Dept Internal Med, Maastricht, Netherlands.
   [Scheijen, Jean L. J. M.; Hanssen, Nordin M. J.; van Greevenbroek, Marleen M.; van der Kallen, Carla J.; Stehouwer, Coen D. A.; Schalkwijk, Casper G.] Cardiovasc Res Inst Maastricht, Maastricht, Netherlands.
   [Feskens, Edith J. M.] Wageningen Univ, Sect Nutr & Epidemiol, Div Human Nutr, Wageningen, Netherlands.
C3 Maastricht University; Maastricht University; Wageningen University &
   Research
RP Schalkwijk, CG (corresponding author), Univ Hosp Maastricht, Lab Metab & Vasc Med, Dept Internal Med, P Debeyelaan 25,POB 5800, NL-6202 AZ Maastricht, Netherlands.
EM j.scheijen@maastrichtuniversity.nl; nmj.hanssen@maastrichtuniversity.nl;
   m.vangreevenbroek@maastrichtuniversity.nl;
   c.vanderkallen@maastrichtuniversity.nl; edith.feskens@wur.nl;
   cda.stehouwer@mumc.nl; c.schalkwijk@maastrichtuniversity.nl
RI Scheijen, Jean/AAY-3799-2020; Feskens, Edith/ABI-1446-2020; Stehouwer,
   Coen/AAB-3435-2021; Hanssen, Nordin/AAC-4277-2020; Smulders,
   YM/AAG-7506-2021
OI Schalkwijk, Casper G/0000-0003-0190-2690; Stehouwer,
   Coen/0000-0001-8752-3223; Scheijen, Jean/0000-0002-1268-2286; van der
   Kallen, Carla/0000-0003-1468-8793; Hanssen, Nordin/0000-0001-9541-7244;
   van Greevenbroek, Marleen/0000-0002-2989-1631
CR Angoorani P, 2016, INT J FOOD SCI NUTR, V67, P170, DOI 10.3109/09637486.2015.1137889
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NR 35
TC 130
Z9 135
U1 0
U2 52
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0261-5614
EI 1532-1983
J9 CLIN NUTR
JI Clin. Nutr.
PD JUN
PY 2018
VL 37
IS 3
BP 919
EP 925
DI 10.1016/j.clnu.2017.03.019
PG 7
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA GG7LN
UT WOS:000432879800021
PM 29381139
OA Green Published
DA 2025-06-11
ER

PT J
AU Zare, Z
   Hosseinzadeh, M
   Sharuni, F
   Rohani, FS
   Hojjat, H
   Rahimpour, S
   Madadizadeh, F
   Reza, JZ
   Wong, A
   Nadjarzadeh, A
AF Zare, Zahra
   Hosseinzadeh, Mahdieh
   Sharuni, Fatemeh
   Rohani, Fatemeh Sadat
   Hojjat, Hashem
   Rahimpour, Shahab
   Madadizadeh, Farzan
   Zavar Reza, Javad
   Wong, Alexei
   Nadjarzadeh, Azadeh
TI The effect of the dietary approaches to stop hypertension diet on total
   antioxidant capacity, superoxide dismutase, catalase, and body
   composition in patients with non-alcoholic fatty liver disease: a
   randomized controlled trial
SO FRONTIERS IN NUTRITION
LA English
DT Article
DE DASH diet; non-alcoholic fatty liver disease; body composition; clinical
   trial DASH diet; clinical trial
ID POLYCYSTIC-OVARY-SYNDROME; HORMONE BINDING GLOBULIN; OXIDATIVE STRESS;
   DASH DIET; BLOOD-PRESSURE; LIFE-STYLE; INSULIN-RESISTANCE; METABOLIC
   SYNDROME; OBESE WOMEN; INTERVENTION
AB AimNon-alcoholic fatty liver disease (NAFLD) is a condition characterized by the accumulation of fat in the liver without excessive alcohol consumption. Lifestyle modifications, such as adopting a healthy diet, represent the standard treatment for NAFLD. However, the impact of the Dietary Approaches to Stop Hypertension (DASH) diet on oxidative stress biomarkers in patients with NAFLD remains unclear. Therefore, this study aimed to determine the effect of the DASH diet on total antioxidant capacity (TAC), catalase (CAT), superoxide dismutase (SOD) levels, and body composition in overweight and obese patients with NAFLD.MethodsA total of 70 overweight and obese patients aged 1870 years were randomly assigned to either the intervention (DASH diet, n = 35) or the control group (control diet, n = 35) for 12 weeks, with both groups following a calorie-restricted diet.ResultsThe mean age of participants was 43.1 +/- 8.1 years in the DASH group and 45.1 +/- 8.6 years in the control group. At the end of the study, a significant difference was observed in the mean TAC and SOD levels between the two groups (p = 0.02). After adjusting for potential confounding factors, such as age, sex, diabetes, smoking, physical activity, and baseline values, the DASH diet maintained its significant effects on TAC and SOD compared to the control diet (p = 0.03). However, there were no significant differences in CAT levels between the two groups. Moreover, a significant reduction in visceral fat (p = 0.01) and a marginally significant decrease in BMI (p = 0.06) were observed in the DASH group compared to the control group after adjusting for potential confounders.ConclusionIn conclusion, our study showed that following the DASH diet for 12 weeks in overweight and obese patients with NAFLD has beneficial effects on TAC, SOD, and visceral fat. These findings support the use of the DASH diet as a potential therapeutic intervention for the improvement of oxidative biomarkers in patients with NAFLD.Clinical trial registrationwww.irct.ir/, identifier IRCT20170117032026N3.
C1 [Zare, Zahra; Hosseinzadeh, Mahdieh; Sharuni, Fatemeh; Rohani, Fatemeh Sadat; Nadjarzadeh, Azadeh] Shahid Sadoughi Univ Med Sci, Sch Publ Hlth, Dept Nutr, Yazd, Iran.
   [Zare, Zahra; Hosseinzadeh, Mahdieh; Sharuni, Fatemeh; Rohani, Fatemeh Sadat; Nadjarzadeh, Azadeh] Shahid Sadoughi Univ Med Sci, Res Ctr Food Hyg & Safety, Sch Publ Hlth, Yazd, Iran.
   [Hojjat, Hashem] Shahid Sadoughi Univ Med Sci, Shahid Sadoughi Hosp, Fac Med, Dept Radiol, Yazd, Iran.
   [Rahimpour, Shahab] Shahid Sadoughi Univ Med Sci, Shahid Sadoughi Hosp, Fac Med, Dept Gastroentrol, Yazd, Iran.
   [Madadizadeh, Farzan] Shahid Sadoughi Univ Med Sci, Ctr Healthcare Data Modeling, Sch Publ Hlth, Dept Biostat, Yazd, Iran.
   [Madadizadeh, Farzan] Shahid Sadoughi Univ Med Sci, Ctr Healthcare Data Modeling, Sch Publ Hlth, Dept Epidemiol, Yazd, Iran.
   [Zavar Reza, Javad] Shahid Sadoughi Univ Med Sci, Fac Med, Dept Clin Biochem, Yazd, Iran.
   [Wong, Alexei] Marymount Univ, Dept Hlth & Human Performance, Arlington, VA USA.
C3 Shahid Sadoughi University of Medical Sciences; Shahid Sadoughi
   University of Medical Sciences; Shahid Sadoughi University of Medical
   Sciences; Shahid Sadoughi University of Medical Sciences; Shahid
   Sadoughi University of Medical Sciences; Shahid Sadoughi University of
   Medical Sciences; Shahid Sadoughi University of Medical Sciences;
   Marymount University
RP Nadjarzadeh, A (corresponding author), Shahid Sadoughi Univ Med Sci, Sch Publ Hlth, Dept Nutr, Yazd, Iran.; Nadjarzadeh, A (corresponding author), Shahid Sadoughi Univ Med Sci, Res Ctr Food Hyg & Safety, Sch Publ Hlth, Yazd, Iran.
EM azadehnajarzadeh@gmail.com
RI Madadizadeh, Farzan/P-6044-2019; Nadjarzadeh, Azadeh/A-8490-2017; Zare,
   Zahra/F-4582-2018
FU This research was financially supported by the Shahid Sadoughi
   University of Medical Sciences, Yazd, Iran.; Shahid Sadoughi University
   of Medical Sciences, Yazd, Iran
FX This research was financially supported by the Shahid Sadoughi
   University of Medical Sciences, Yazd, Iran.
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NR 47
TC 10
Z9 10
U1 3
U2 8
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD OCT 20
PY 2023
VL 10
AR 1163516
DI 10.3389/fnut.2023.1163516
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA W6DR4
UT WOS:001092516200001
PM 37927493
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Porada, D
   Golacki, J
   Matyjaszek-Matuszek, B
AF Porada, Dominik
   Golacki, Jakub
   Matyjaszek-Matuszek, Beata
TI Obesity in perimenopause - current treatment options based on
   pathogenetic factors
SO ENDOKRYNOLOGIA POLSKA
LA English
DT Review
DE menopause; perimenopause; obesity; pharmacotherapy; menopausal hormone
   therapy
ID HORMONE REPLACEMENT THERAPY; STRESS-INDUCED CORTISOL;
   METABOLIC-SYNDROME; BODY-COMPOSITION; GROWTH-HORMONE; MENOPAUSAL
   TRANSITION; POSTMENOPAUSAL WOMEN; LEPTIN RESISTANCE; BINDING GLOBULIN;
   SEX-HORMONES
AB The health of post-menopausal women has become of paramount concern due to the aging of the world's population. Concurrently, the prevalence of obesity among postmenopausal women is expected to increase, presenting a significant public health challenge. Although weight gain during menopause is a well-observed phenomenon, its underlying causes and mechanisms remain incompletely understood. This manuscript reviews the literature to explore potential hormonal factors and pathomechanisms contributing to obesity during perimenopause, aiming to identify pathogenic factors that can guide treatment selection. Menopause-induced hormonal changes, including hypoestrogenaemia, hypergonadotropinaemia, relative hyperandrogenaemia, growth hormone deficiency, leptin resistance, and chronic stress affecting the hypothalamic-pituitary-adrenal axis, have been implicated in the onset of obesity in perimenopausal women. These hormonal fluctuations, alongside lowered daily energy expenditure, lead to metabolic alterations that elevate the risk of developing metabolic disorders and cardiovascular diseases. Weight gain in perimenopausal women is associated with higher total and abdominal adipose tissue and lower lean body mass. Addressing this issue requires individualized behavioural management, supported by effective pharmacological therapy, and, when warranted, complemented by bariatric surgery. Modern obesity treatment therapies have demonstrated safety and efficacy in clinical trials, offering the potential to reduce excess body fat, improve metabolic profiles, lower cardiovascular risk, and enhance the quality and longevity of women's lives. In addition to standard obesity therapies, the article examines different treatment strategies based on obesity's pathogenic factors, which may offer promising options for treating obesity with or without complications in perimenopausal women. One such potential approach is menopausal hormone therapy (MHT), which hypothetically targets visceral obesity by reducing visceral adipose tissue accumulation, preserving metabolically active lean body mass, and improving lipid profiles. However, despite these reported benefits, gynaecological and endocrinological societies currently do not recommend the use of MHT for obesity prevention or treatment, necessitating further research for validation. Emerging evidence suggests that visceral obesity could result from hypoestrogenaemia during perimenopause, potentially justifying the use of MHT as a causal treatment. This highlights the importance of advancing research efforts to unravel the intricate hormonal and metabolic changes that occur during perimenopause and their role in obesity development. (Endokrynol Pol 2023; 74 (6): 565-575)
C1 [Porada, Dominik; Golacki, Jakub; Matyjaszek-Matuszek, Beata] Med Univ Lublin, Chair & Dept Endocrinol Diabetol & Metab Dis, Lublin, Poland.
C3 Medical University of Lublin
RP Golacki, J (corresponding author), Med Univ Lublin, Chair & Dept Endocrinol Diabetol & Metab Dis, Jaczewskiego 8, PL-20954 Lublin, Poland.
EM jakub.golacki@gmail.com
RI Golacki, Jakub/JTS-3973-2023
OI Golacki, Jakub/0000-0001-8502-3030
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NR 85
TC 2
Z9 2
U1 1
U2 7
PU VIA MEDICA
PI GDANSK
PA UL SWIETOKRZYSKA 73, 80-180 GDANSK, POLAND
SN 0423-104X
J9 ENDOKRYNOL POL
JI Endokrynol. Pol.
PY 2023
VL 74
IS 6
BP 565
EP 575
DI 10.5603/ep.96679
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA EE7C7
UT WOS:001137299200001
PM 37994584
OA gold
DA 2025-06-11
ER

PT J
AU Ismaiel, A
   Dumitrascu, DL
AF Ismaiel, Abdulrahman
   Dumitrascu, Dan L.
TI Cardiovascular Risk in Fatty Liver Disease: The Liver-Heart Axis-
   Literature Review
SO FRONTIERS IN MEDICINE
LA English
DT Review
DE cardiovascular disease (CV disease); non-alcoholic fatty liver disease
   (NAFLD); alcoholic liver disease (ALD); cardiac arrhythmias; metabolic
   syndrome (MetS)
ID INTIMA-MEDIA THICKNESS; CORONARY-ARTERY CALCIFICATION; HEPATIC
   STEATOSIS; NONALCOHOLIC STEATOHEPATITIS; SUBCLINICAL ATHEROSCLEROSIS;
   EPICARDIAL FAT; CAROTID ATHEROSCLEROSIS; INSULIN SENSITIVITY; ALANINE
   AMINOTRANSFERASE; GENERAL-POPULATION
AB According to the World Health Organization, cardiovascular disease (CVD) remains the leading cause of death worldwide, accounting for approximately 18 million deaths per year. Nevertheless, the worldwide prevalence of metabolic diseases, such as type 2 diabetes mellitus, obesity, and non-alcoholic fatty liver disease (NAFLD), also known to be common risk factors for CVD, have dramatically increased over the last decades. Chronic alcohol consumption is a major cause of chronic liver diseases (CUD) as well as being a major health care cost expenditure accounting for the spending of tremendous amounts of money annually. NAFLD has become one of the major diseases plaguing the world while standing as the most common cause of liver disease in the Western countries by representing about 75% of all CLD. Currently, the most common cause of death in NAFLD remains to be CVD. Several mechanisms have been suggested to be responsible for associating FLD with CVD through several mechanisms including low-grade systemic inflammation, oxidative stress, adipokines, endoplasmic reticulum stress, lipotoxicity and microbiota dysbiosis which may also be influenced by other factors such as genetic and epigenetic variations. Despite of all this evidence, the exact mechanisms of how FLD can causally contribute to CVD are not fully elucidated and much remains unknown. Moreover, the current literature supports the increasing evidence associating FLD with several cardiovascular (CV) adverse events including coronary artery disease, increased subclinical atherosclerosis risk, structural alterations mainly left ventricular hypertrophy, increased epicardial fat thickness, valvular calcifications including aortic valve sclerosis and mitral annular calcification and functional cardiac modifications mainly diastolic dysfunction in addition to cardiac arrhythmias such as atrial fibrillation and ventricular arrythmias and conduction defects including atrioventricular blocks and bundle branch blocks. Patients with FLD should be evaluated and managed accordingly in order to prevent further complications. Possible management methods include non-pharmacological strategies including life style modifications, pharmacological therapies as well as surgical management. This review aims to summarize the current state of knowledge regarding the pathophysiological mechanisms linking FLD with an increased CV risk, in addition to associated CV adverse events and current management modalities.
C1 [Ismaiel, Abdulrahman; Dumitrascu, Dan L.] Iuliu Hatieganu Univ Med & Pharm, Cluj Napoca, Romania.
   [Ismaiel, Abdulrahman; Dumitrascu, Dan L.] Iuliu Hatieganu Univ Med & Pharm, Internal Med Dept 2, Cluj Napoca, Romania.
C3 Iuliu Hatieganu University of Medicine & Pharmacy; Iuliu Hatieganu
   University of Medicine & Pharmacy
RP Ismaiel, A (corresponding author), Iuliu Hatieganu Univ Med & Pharm, Cluj Napoca, Romania.; Ismaiel, A (corresponding author), Iuliu Hatieganu Univ Med & Pharm, Internal Med Dept 2, Cluj Napoca, Romania.
EM abdulrahman.ismaiel@yahoo.com
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NR 186
TC 118
Z9 126
U1 1
U2 17
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 2296-858X
J9 FRONT MED-LAUSANNE
JI Front. Med.
PD SEP 13
PY 2019
VL 6
AR 202
DI 10.3389/fmed.2019.00202
PG 18
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA IX5OA
UT WOS:000485732300001
PM 31616668
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Salma, W
   Franekova, V
   Lund, T
   Höper, A
   Ludvigsen, S
   Lund, J
   Aasum, E
   Ytrehus, K
   Belke, DD
   Larsen, TS
AF Salma, Wahida
   Franekova, Veronika
   Lund, Trine
   Hoper, Anje
   Ludvigsen, Stian
   Lund, Jim
   Aasum, Ellen
   Ytrehus, Kirsti
   Belke, Darrell D.
   Larsen, Terje S.
TI Dietary Calanus oil antagonizes angiotensin II-induced hypertension and
   tissue wasting in diet-induced obese mice
SO PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
LA English
DT Article
DE Obesity; Hypertension; Marine oil; Protein O-GlcNAcylation; Inflammation
ID POLYUNSATURATED FATTY-ACIDS; PROTEIN O-GLCNACYLATION;
   CARDIOVASCULAR-DISEASE; INSULIN-RESISTANCE; DOCOSAHEXAENOIC ACID;
   SIGNALING PATHWAYS; GLCNAC TRANSFERASE; METABOLIC SYNDROME; OXIDATIVE
   STRESS; ADIPOSE-TISSUE
AB Background: We have recently shown that Calanus oil, which is extracted from the marine copepod Calanus finmarchicus, reduces fat deposition, suppresses adipose tissue inflammation and improves insulin sensitivity in high fat-fed rodents. This study expands upon our previous observations by examining whether dietary supplementation with Calanus oil could antagonize angiotensin II (Ang II) induced hypertension and ventricular remodeling in mice given a high fat diet (HFD).
   Methods: C57BL/6J mice were initially subjected to 8 weeks of HFD with or without 2% (w/w) Calanus oil. Thereafter, animals within each group were randomized for the administration of either Ang II (1 mu g/kg/min) or saline for another two weeks, while still on the same dietary regimen.
   Results: Ang II caused a marked decline in body and organ weights in mice receiving non -supplemented HFD, a response which was clearly attenuated in mice receiving Calanus oil supplementation. Furthermore, Ang II-induced elevation in blood pressure was also attenuated in the Calanus oil-supplemented group. As expected, infusion of Ang II produced hypertrophy and up-regulation of marker genes (mRNA level) of both hypertrophy and fibrosis in cardiac muscle, but this response was unaffected by dietary Calanus oil. Fibrosis and inflammation were up-regulated also in the aorta following Ang 11 infusion. However, the inflammatory response was blocked by Calanus oil supplementation. A final, and unexpected, finding was that dietary intake of Calanus oil caused a robust increase in the level of O-GlcNAcylation in cardiac tissue.
   Conclusion: These results suggest that dietary intake of oil from the marine copepod Calanus finmarchicus could be a beneficial addition to conventional hypertension treatment. The compound attenuates inflammation and the severe metabolic stress caused by Ang II infusion. Although the present study suggests that the anti-hypertensive effect of the oil (or its n-3 PUFAs constituents) is related to its anti-inflammatory action in the vessel wall, other mechanisms such as interaction with intracellular calcium mechanisms or a direct antagonistic effect on Ang II receptors should be examined. (C) 2016 Elsevier Ltd. All rights reserved.
C1 [Salma, Wahida; Franekova, Veronika; Lund, Trine; Hoper, Anje; Ludvigsen, Stian; Lund, Jim; Aasum, Ellen; Ytrehus, Kirsti; Larsen, Terje S.] UiT Arctic Univ Norway, Fac Hlth Sci, Dept Med Biol, Cardiovasc Res Grp, N-9037 Tromso, Norway.
   [Belke, Darrell D.] Univ Calgary, Fac Kinesiol, 3300 Univ Dr NW, Calgary, AB T2N 4N1, Canada.
C3 UiT The Arctic University of Tromso; University of Calgary
RP Larsen, TS (corresponding author), UiT Arctic Univ Norway, Fac Hlth Sci, Dept Med Biol, Cardiovasc Res Grp, N-9037 Tromso, Norway.
EM terje.larsen@uit.no
RI Höper, Anje Christina/KHU-4443-2024
OI Hoper, Anje Christina/0000-0002-8962-5853; Belke,
   Darrell/0009-0002-4418-7201
FU UiT the Arctic University of Norway; Norwegian Heart Foundation; Calanus
   AS, Tromso, Norway
FX This work was supported by UiT the Arctic University of Norway, the
   Norwegian Heart Foundation and Calanus AS, Tromso, Norway.
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NR 48
TC 8
Z9 8
U1 2
U2 12
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0952-3278
EI 1532-2823
J9 PROSTAG LEUKOTR ESS
JI Prostaglandins Leukot. Essent. Fatty Acids
PD MAY
PY 2016
VL 108
BP 13
EP 21
DI 10.1016/j.plefa.2016.03.006
PG 9
WC Biochemistry & Molecular Biology; Cell Biology; Endocrinology &
   Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology; Endocrinology &
   Metabolism
GA DM9VG
UT WOS:000376713200003
PM 27154360
DA 2025-06-11
ER

PT J
AU Dengel, DR
   Jacobs, DR
   Steinberger, J
   Moran, AM
   Sinaiko, AR
AF Dengel, Donald R.
   Jacobs, David R., Jr.
   Steinberger, Julia
   Moran, Antoinette M.
   Sinaiko, Alan R.
TI Gender differences in vascular function and insulin sensitivity in young
   adults
SO CLINICAL SCIENCE
LA English
DT Article
DE adolescent; cardiovascular risk; echocardiography; endothelium-derived
   dilation; gender; insulin sensitivity; young adulthood
ID FLOW-MEDIATED DILATION; ENDOTHELIUM-DEPENDENT VASODILATION;
   CARDIOVASCULAR RISK-FACTORS; COMMON CAROTID-ARTERY; BODY-MASS INDEX;
   BRACHIAL-ARTERY; OXIDATIVE STRESS; OBESE CHILDREN; SHEAR-STRESS;
   DYSFUNCTION
AB To examine influence of insulin resistance and other clinical risk factors for the MetS (metabolic syndrome) on vascular structure and function in young adults. This cross-sectional study was conducted in a cohort of young adults (mean age 22 years) and their siblings participating in a longitudinal study of cardiovascular risk (n = 370). Insulin sensitivity was determined by euglycaemic insulin clamp. EDD (endothelium-dependent dilation) was determined by flow-mediated dilation using high-resolution ultrasound imaging of the brachial artery. EID (endothelium-independent dilation) was determined by NTG (nitroglycerine)-mediated dilation. The diameter and cIMT (intima media thickness) of the carotid artery were also measured. There was no significant difference between males and females for age or body mass index. However, males had significantly higher glucose and triacylglycerol (triglyceride) levels, while the females had significantly higher HDL-C (high-density lipoprotein-cholesterol) and insulin sensitivity (13.00 +/- 0.33 compared with 10.71 +/- 0.31 mg.kg(-1) of lean body mass.min(-1), P < 0.0001). Although peak EDD was significantly lower (6.28 +/- 0.26 compared with 8.50 +/- 0.28%, P < 0.0001) in males than females, this difference was largely explained by adjustment for brachial artery diameter (P = 0.15). Peak EID also was significantly lower in males than females (20.26 +/- 0.44 compared with 28.64 +/- 0.47%, P < 0.0001), a difference that remained significantly lower after adjustment for brachial artery diameter. Males had a significantly greater cIMT compared with females (females 0.420 +/- 0.004 compared with males 0.444 +/- 0.004 mm, P = 0.01), but when adjusted for carotid diameter, there was no significant difference (P = 0.163). Although there were gender differences in vascular function and structure in the young adult population examined in this study, many of the differences were eliminated simply by adjusting for artery diameter. However, the lower EID observed in males could not be explained by artery diameter. Future studies need to continue to examine influence of gender on EID and other measures of vascular function.
C1 [Dengel, Donald R.] Univ Minnesota, Sch Kinesiol, Minneapolis, MN 55455 USA.
   [Dengel, Donald R.] Minneapolis Vet Affairs Med Ctr, Minneapolis, MN 55417 USA.
   [Dengel, Donald R.; Steinberger, Julia; Moran, Antoinette M.; Sinaiko, Alan R.] Univ Minnesota, Dept Pediat, Minneapolis, MN 55455 USA.
   [Jacobs, David R., Jr.] Univ Minnesota, Sch Publ Hlth, Div Epidemiol & Community Hlth, Minneapolis, MN 55455 USA.
C3 University of Minnesota System; University of Minnesota Twin Cities; US
   Department of Veterans Affairs; Veterans Health Administration (VHA);
   Minneapolis VA Health Care System; University of Minnesota System;
   University of Minnesota Twin Cities; University of Minnesota System;
   University of Minnesota Twin Cities
RP Dengel, DR (corresponding author), Univ Minnesota, Sch Kinesiol, Minneapolis, MN 55455 USA.
EM denge001@umn.edu
RI Jacobs, David/G-5405-2011
OI Steinberger, Julia/0000-0002-2892-8594; Jacobs,
   David/0000-0002-7232-0543
FU National Institutes of Health [HL-52851, M01-RR-00400]
FX This work was supported by the National Institutes of Health [grant
   numbers HL-52851 and M01-RR-00400 (to the General Clinical Research
   Centers)].
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NR 48
TC 29
Z9 35
U1 0
U2 4
PU PORTLAND PRESS LTD
PI LONDON
PA CHARLES DARWIN HOUSE, 12 ROGER STREET, LONDON WC1N 2JU, ENGLAND
SN 0143-5221
EI 1470-8736
J9 CLIN SCI
JI Clin. Sci.
PD FEB
PY 2011
VL 120
IS 3-4
BP 153
EP 160
DI 10.1042/CS20100223
PG 8
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 720IO
UT WOS:000287274500006
PM 20815810
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Rehan, ST
   Siddiqui, AH
   Khan, Z
   Imran, L
   Syed, AA
   Tahir, MJ
   Jassani, Z
   Singh, M
   Asghar, MS
   Ahmed, A
AF Rehan, Syeda Tayyaba
   Siddiqui, Abdul Hannan
   Khan, Zayeema
   Imran, Laiba
   Syed, Abdul Ahad
   Tahir, Muhammad Junaid
   Jassani, Zahra
   Singh, Manjeet
   Asghar, Muhammad Sohaib
   Ahmed, Ali
TI Samidorphan/olanzapine combination therapy for schizophrenia: Efficacy,
   tolerance and adverse outcomes of regimen, evidence-based review of
   clinical trials
SO ANNALS OF MEDICINE AND SURGERY
LA English
DT Review
DE Samidorphan; Olanzapine; Schizophrenia; Review; Research; Systematic;
   Psychiatric
ID 2ND-GENERATION ANTIPSYCHOTICS; DOUBLE-BLIND; OLANZAPINE; SAFETY;
   METAANALYSIS; DEPRESSION
AB Introduction: Schizophrenia is a complex medical illness characterized by hallucinations, delusions, and cognitive issues. Olanzapine, a second-generation antipsychotic widely prescribed for schizophrenia has proven to be efficacious, however, its use is associated with major adverse effects such as weight gain, metabolic syndrome and diabetes mellitus. Recently, FDA approved a combination dose of olanzapine and samidorphan (OLZ/SAM) to mitigate the adverse outcomes associated with olanzapine use for the treatment of Schizophrenia.
   Objectives: The approval of olanzapine/samidorphan combination by FDA in treatment of schizophrenia and bipolar I disorder has been a milestone. This article summarizes the clinical trials reporting the clinical efficacy and adverse effects of olanzapine/samidorphan combination along with their bias assessment.
   Methods: Pubmed, science direct, Ovid SP and Google Scholar were comprehensively searched for data collection. Clinical trials reporting the efficacy and adverse outcomes of the OLZ/SAM regimen were included in the review and the Cochrane risk of bias assessment tool (RoB 2.0, version 2019) was used to assess the risk of bias in each study.
   Results: Five trials employed the use of Positive and Negative Syndrome Scales (PANSS) and Clinical Global Impression-Severity (CGI-S) scale to assess the efficacy of OLZ/SAM. Overall, OLZ/SAM showed a significant reduction in PANSS total scores and CGI-S scores and might be a viable option for long-term treatment. The safety of combined therapy is assessed by trials considering the factors of ECG parameters, suicidal events, and movement disorders. Major adverse events included nervous system disorders, changes in blood chemistry, and metabolic or nutritional disorders, with worsening of adverse outcomes observed in a total of nineteen cases in six studies.
   Conclusion: The FDA-approved drug recombination of OLZ/SAM for the treatment of schizophrenia revealed efficacious outcomes and was generally well tolerated by patients partaking in various trials. The potential of samidorphan in mimicking the efficacy of olanzapine while mitigating olanzapine-induced weight gain makes it a promising regimen for improving symptoms and health outcomes in schizophrenic patients.
C1 [Rehan, Syeda Tayyaba; Siddiqui, Abdul Hannan; Khan, Zayeema; Imran, Laiba; Syed, Abdul Ahad] Dow Univ Hlth Sci, Dept Med, Karachi 74200, Sindh, Pakistan.
   [Tahir, Muhammad Junaid] Lahore Gen Hosp, Dept Med, Lahore 54000, Punjab, Pakistan.
   [Jassani, Zahra] Liaquat Natl Hosp & Med Coll, Dept Psychiat, Karachi 74800, Sindh, Pakistan.
   [Singh, Manjeet] Liaquat Natl Hosp & Med Coll, Dept Internal Med, Karachi 74800, Sindh, Pakistan.
   [Asghar, Muhammad Sohaib] Dow Univ Hlth Sci, Dept Med, Ojha Campus,B328,Block 6, Karachi 75300, Sindh, Pakistan.
   [Ahmed, Ali] Monash Univ, Sch Pharm, Jalan Lagoon Selatan, Subang Jaya 47500, Selangor, Malaysia.
C3 Dow University of Health Sciences; Dow University of Health Sciences;
   Monash University; Monash University Malaysia
RP Asghar, MS (corresponding author), Dow Univ Hlth Sci, Dept Med, Ojha Campus,B328,Block 6, Karachi 75300, Sindh, Pakistan.
EM tayyabarehan50@gmail.com; abdul.siddiqui19@dmc.duhs.edu.pk;
   zayeemakhan6@gmail.com; laibaimran2001@gmail.com; ahadshah321@gmail.com;
   junaid262626@gmail.com; zahrajass@hotmail.com;
   manjeet13132020@outlook.com; sohaib_asghar123@yahoo.com;
   ali.ahmed@monash.edu
RI Tahir, Muhammad/AAX-9556-2020; Asghar, Muhammad Sohaib/ABB-7824-2020;
   Ahmed, Ali/P-2122-2015
OI Khan, Zayeema/0000-0002-1835-0514; Asghar, Muhammad
   Sohaib/0000-0001-6705-2030; Ahmed, Ali/0000-0002-8964-1853; Syed, Abdul
   Ahad/0000-0002-9590-682X; Siddiqui, Abdul Hannan/0000-0001-6606-3280;
   Imran, Laiba/0000-0002-9869-0921; Rehan, Syeda
   Tayyaba/0000-0001-6724-2360
CR [Anonymous], 2021, Zyprexa Package Insert
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NR 44
TC 7
Z9 7
U1 0
U2 1
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 2049-0801
J9 ANN MED SURG
JI Ann. Med. Surg.
PD JUL
PY 2022
VL 79
AR 104115
DI 10.1016/j.amsu.2022.104115
EA JUL 2022
PG 10
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA 4Z8KJ
UT WOS:000862450000040
PM 35860157
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Armstrong, AW
   Zhao, Y
   Herrera, V
   Li, YF
   Bancroft, T
   Hull, M
   Altan, A
AF Armstrong, April W.
   Zhao, Yang
   Herrera, Vivian
   Li, Yunfeng
   Bancroft, Tim
   Hull, Michael
   Altan, Aylin
TI Rethinking costs of psoriasis: 10% of patients account for nearly 40% of
   healthcare expenditures among enrollees with psoriasis in a US health
   plan
SO JOURNAL OF DERMATOLOGICAL TREATMENT
LA English
DT Article
DE Psoriasis; healthcare utilization; healthcare costs; biologic
   medications
ID UNITED-STATES; BIOLOGIC THERAPIES; METABOLIC SYNDROME; ECONOMIC BURDEN;
   POPULATION; PREVALENCE; MODERATE
AB Objective: To examine characteristics, healthcare utilization and costs among patients with psoriasis who have high medical costs.Methods: This is a retrospective study of patients with psoriasis with continuous enrollment from 1 January 2011 to 31 December 2013 in a large US health plan. Total paid 2012 healthcare costs excluding biologics (to identify costliest not due to biologic costs) were used to create cohorts representing the top 10% (T10) and bottom 90% (B90) of expenditures. Demographics, comorbidities, prescriptions, all-cause and psoriasis-related healthcare utilization and costs were compared between cohorts. Logistic regression identified demographic and clinical characteristics associated with the 2012 T10 cohort status.Results: 18,653 patients (mean age 48 years; 49% female) were included. Patients in the T10 group accounted for 26% (2011), 39% (2012) and 26% (2013) of all-cause costs including biologics and 13% (2011), 18% (2012) and 11% (2013) of psoriasis-related costs. Mean 2012 total costs were $58,030 for T10 vs. $10,295 for B90 (all-cause) and $10,475 vs. $5301 (psoriasis-related). T10 patients in 2012 filled more prescriptions and were more likely to use corticosteroids (57% vs. 31%); however, biologic use and costs were similar (any use: 23% vs. 24%; prescriptions: 1.5 vs. 1.7, biologic costs: $4959 vs. $5095). Compared with B90 patients, T10 patients were more likely to have hospitalizations (all-cause: 45% vs. 3%; psoriasis-related: 14% vs. 1%) and ER visits (all-cause: 53% vs. 21%; psoriasis-related: 3% vs. 1%), and more likely to have renal disease (odds ratio (OR)=2.05), depression (OR =1.96), cardiovascular disease (OR =1.88), psoriatic arthritis (OR =1.57) and diabetes (OR =1.50) (all p<.05).Conclusions: The T10 patient cohort in 2012 accounted for nearly 40% of overall healthcare expenditures. However, cost differences between the T10 and B90 patients were not attributable to psoriasis-related biologic treatment utilization and costs. The T10 patients had significantly more inpatient and emergency utilization, and comorbid medical conditions.
C1 [Armstrong, April W.] Univ Southern Calif, Los Angeles, CA USA.
   [Zhao, Yang; Herrera, Vivian; Li, Yunfeng] Novartis Pharmaceut, Hlth Econ & Outcomes Res, E Hanover, NJ 07936 USA.
   [Bancroft, Tim; Hull, Michael] Optum, Hlth Econ & Outcomes Res, Eden Prairie, MN USA.
   [Altan, Aylin] Optum Labs, Eden Prairie, MN USA.
C3 University of Southern California; Novartis; Novartis USA; Optum; Optum
RP Zhao, Y (corresponding author), Novartis Pharmaceut, US Hlth Econ & Outcomes Res, One Hlth Plaza, E Hanover, NJ 07936 USA.
EM yang-3.zhao@novartis.com
FU Novartis Pharmaceuticals Corporation (NPC); Optum, Inc.
FX This study was supported by Novartis Pharmaceuticals Corporation (NPC),
   financial support was provided in the form of employment (Zhao, Li,
   Herrera); consultancies (Armstrong); and contract (Optum, Inc.), by
   which authors Bancroft, Hull and Altan, and medical writer C.
   Jennermann, are employed. Dr. Armstrong is employed by the University of
   Southern California, Los Angeles.
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NR 21
TC 0
Z9 0
U1 0
U2 1
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0954-6634
EI 1471-1753
J9 J DERMATOL TREAT
JI J. Dermatol. Treat.
PY 2017
VL 28
IS 7
BP 613
EP 622
DI 10.1080/09546634.2017.1303566
PG 10
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA FN2RX
UT WOS:000415842300008
PM 28320213
DA 2025-06-11
ER

PT J
AU Crump, C
   Sundquist, K
   Winkleby, MA
   Sundquist, J
AF Crump, Casey
   Sundquist, Kristina
   Winkleby, Marilyn A.
   Sundquist, Jan
TI Comorbidities and Mortality in Bipolar Disorder A Swedish National
   Cohort Study
SO JAMA PSYCHIATRY
LA English
DT Article
ID PSYCHIATRIC MEDICATION PRESCRIPTION; METABOLIC SYNDROME;
   SUICIDE-PREVENTION; CIGARETTE-SMOKING; SPECTRUM DISORDER; RISK-FACTORS;
   PREVALENCE; CANCER; SCHIZOPHRENIA; DEPRESSION
AB IMPORTANCE Bipolar disorder is associated with premature mortality, but the specific causes and underlying pathways are unclear.
   OBJECTIVE To examine the physical health effects of bipolar disorder using outpatient and inpatient data for a national population.
   DESIGN, SETTING, AND PARTICIPANTS National cohort study of 6 587 036 Swedish adults, including 6618 with bipolar disorder.
   MAIN OUTCOMES AND MEASURES Physical comorbidities diagnosed in any outpatient or inpatient setting nationwide and mortality (January 1, 2003, through December 31, 2009).
   RESULTS Women and men with bipolar disorder died 9.0 and 8.5 years earlier on average than the rest of the population, respectively. All-cause mortality was increased 2-fold among women (adjusted hazard ratio [aHR], 2.34; 95% CI, 2.16-2.53) and men (aHR, 2.03; 95% CI, 1.85-2.23) with bipolar disorder, compared with the rest of the population. Patients with bipolar disorder had increased mortality from cardiovascular disease, diabetes mellitus, chronic obstructive pulmonary disease (COPD), influenza or pneumonia, unintentional injuries, and suicide for both women and men and cancer for women only. Suicide risk was 10-fold among women (aHR, 10.37; 95% CI, 7.36-14.60) and 8-fold among men (aHR, 8.09; 95% CI, 5.98-10.95) with bipolar disorder, compared with the rest of the population. Substance use disorders contributed only modestly to these findings. The association between bipolar disorder and mortality from chronic diseases (ischemic heart disease, diabetes, COPD, or cancer) was weaker among persons with a prior diagnosis of these conditions (aHR, 1.40; 95% CI, 1.26-1.56) than among those without a prior diagnosis (aHR, 2.38; 95% CI, 1.95-2.90; P-interaction = .01).
   CONCLUSIONS AND RELEVANCE In this large national cohort study, patients with bipolar disorder died prematurely from multiple causes, including cardiovascular disease, diabetes, COPD, influenza or pneumonia, unintentional injuries, and suicide. However, chronic disease mortality among those with more timely medical diagnosis approached that of the general population, suggesting that better provision of primary medical care may effectively reduce premature mortality among persons with bipolar disorder.
C1 [Crump, Casey] Stanford Univ, Dept Med, Div Gen Med Disciplines, Stanford, CA 94305 USA.
   [Sundquist, Kristina; Winkleby, Marilyn A.; Sundquist, Jan] Stanford Univ, Dept Med, Stanford Prevent Res Ctr, Stanford, CA 94305 USA.
   [Sundquist, Kristina; Sundquist, Jan] Lund Univ, Ctr Primary Hlth Care Res, Malmo, Sweden.
C3 Stanford University; Stanford University; Lund University
RP Crump, C (corresponding author), Stanford Univ, Dept Med, 211 Quarry Rd,Ste 405,MC 5985, Palo Alto, CA 94304 USA.
RI Crump, Casey/AAO-8802-2021
FU National Institute of Drug Abuse [R01DA030005]; Avtal om Lakarutbildning
   och Forskning (Agreement on Medical Training and Research) project
   grant, Lund, Sweden
FX This study was supported by grant R01DA030005 from the National
   Institute of Drug Abuse and an Avtal om Lakarutbildning och Forskning
   (Agreement on Medical Training and Research) project grant, Lund,
   Sweden.
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NR 59
TC 516
Z9 539
U1 2
U2 50
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 2168-622X
EI 2168-6238
J9 JAMA PSYCHIAT
JI JAMA Psychiatry
PD SEP
PY 2013
VL 70
IS 9
BP 931
EP 939
DI 10.1001/jamapsychiatry.2013.1394
PG 9
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 228JN
UT WOS:000325182200008
PM 23863861
DA 2025-06-11
ER

PT J
AU Wang, M
   Li, S
   Wang, FBH
   Zou, JH
   Zhang, YF
AF Wang, Mei
   Li, Sen
   Wang, Fubaihui
   Zou, Jinhui
   Zhang, Yanfeng
TI Aerobic exercise regulates blood lipid and insulin resistance via the
   toll-like receptor 4-mediated extracellular signal-regulated
   kinases/AMP-activated protein kinases signaling pathway
SO MOLECULAR MEDICINE REPORTS
LA English
DT Article
DE aerobic exercise; diabetes mellitus; blood lipid; insulin resistance;
   toll-like receptor 4; extracellular signal-regulated kinases;
   AMP-activated protein kinase
ID TYPE-2 DIABETES-MELLITUS; TLR4 GENE POLYMORPHISMS; CHRONIC
   KIDNEY-DISEASE; OXIDATIVE STRESS; INFLAMMATORY CYTOKINES;
   CARDIOVASCULAR-DISEASE; HEART-DISEASE; MICROVASCULAR DYSFUNCTION;
   VASCULAR COMPLICATIONS; GLUCOSE-TOLERANCE
AB Diabetes mellitus is a complicated metabolic disease with symptoms of hyperglycemia, insulin resistance, chronic damage and dysfunction of tissues, and metabolic syndrome for insufficient insulin production. Evidence has indicated that exercise treatments are essential in the progression of type- diabetes mellitus, and affect insulin resistance and activity of islet -cells. In the present study, the efficacy and signaling mechanism of aerobic exercise on blood lipids and insulin resistance were investigated in the progression of type- diabetes mellitus. Body weight, glucose metabolism and insulin serum levels were investigated in mouse models of type- diabetes mellitus following experienced aerobic exercise. Expression levels of inflammatory factors, interleukin (IL)-6, high-sensitivity C-reactive protein, tumor necrosis factor- and leucocyte differentiation antigens, soluble CD40 ligand in the serum were analyzed in the experimental mice. In addition, expression levels of toll-like receptor 4 (TLR-4) were analyzed in the liver cells of experimental mice. Changes of oxidative stress indicators, including reactive oxygen species, superoxide dismutase, glutathione and catalase were examined in the liver cells of experimental mice treated by aerobic exercise. Expression levels and activity of extracellular signal-regulated kinases (ERK) and AMP-activated protein kinase (AMPK) signaling pathways were investigated in the liver cells of mouse models of type- diabetes mellitus after undergoing aerobic exercise. Aerobic exercise decreased the expression levels of inflammatory factors in the serum of mouse models of type- diabetes mellitus. The results indicated that aerobic exercise downregulated oxidative stress indicators in liver cells from mouse models of type- diabetes mellitus. In addition, the ERK and AMPK signaling pathways were inactivated by aerobic exercise in liver cells in mouse models of type- diabetes mellitus. The activity of ERK and AMPK, and the function of islet -cells were observed to be improved in experimental mice treated with aerobic exercise. Furthermore, blood lipid metabolism and insulin resistance were improved by treatment with aerobic exercise. Body weight and glucose concentration of serology was markedly improved in mouse models of type- diabetes mellitus. Furthermore, TLR-4 inhibition markedly promoted ERK and AMPK expression levels and activity. Thus, these results indicate that aerobic exercise may improve blood lipid metabolism, insulin resistance and glucose plasma concentration in mouse models of type- diabetes mellitus. Thus indicating aerobic exercise is beneficial for improvement of blood lipid and insulin resistance via the TLR-4-mediated ERK/AMPK signaling pathway in the progression of type- diabetes mellitus.
C1 [Wang, Mei; Wang, Fubaihui; Zhang, Yanfeng] Mass Sports Res Ctr, State Gen Adm Sports, Sports Sci Inst, 73 Fusurong Rd, Beijing 100061, Peoples R China.
   [Li, Sen] Jiangsu Inst Sports Sci, Nanjing 210033, Jiangsu, Peoples R China.
   [Zou, Jinhui] Guangxi Inst Sports Sci Mass Sports Res, Nanning 210014, Guangxi, Peoples R China.
RP Zhang, YF (corresponding author), Mass Sports Res Ctr, State Gen Adm Sports, Sports Sci Inst, 73 Fusurong Rd, Beijing 100061, Peoples R China.
EM zhangyanfengty@163.com
RI Zhang, Yanfeng/AAW-3915-2020; Wang, Meiling/GSI-6167-2022
FU Science and Technology Infrastructure Plan of Jiangsu Province
   [BM2013068]; Science and Technology Support Program of Jiangsu province
   [BE2014727]
FX The present study was supported by The Science and Technology Support
   Program of Jiangsu province (grant no. BE2014727) and The Science and
   Technology Infrastructure Plan of Jiangsu Province (grant no.
   BM2013068).
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NR 60
TC 11
Z9 15
U1 4
U2 28
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1791-2997
EI 1791-3004
J9 MOL MED REP
JI Mol. Med. Rep.
PD JUN
PY 2018
VL 17
IS 6
BP 8339
EP 8348
DI 10.3892/mmr.2018.8863
PG 10
WC Oncology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Research & Experimental Medicine
GA GJ5AQ
UT WOS:000435394000108
PM 29658605
OA Bronze
DA 2025-06-11
ER

PT J
AU Thonusin, C
   Pantiya, P
   Sumneang, N
   Chunchai, T
   Nawara, W
   Arunsak, B
   Siri-Angkul, N
   Sriwichaiin, S
   Chattipakorn, SC
   Chattipakorn, N
AF Thonusin, Chanisa
   Pantiya, Patcharapong
   Sumneang, Natticha
   Chunchai, Titikorn
   Nawara, Wichwara
   Arunsak, Busarin
   Siri-Angkul, Natthaphat
   Sriwichaiin, Sirawit
   Chattipakorn, Siriporn C.
   Chattipakorn, Nipon
TI Effectiveness of high cardiorespiratory fitness in cardiometabolic
   protection in prediabetic rats
SO MOLECULAR MEDICINE
LA English
DT Article
DE Prediabetes; Lifestyle modification; Weight maintenance;
   Cardiorespiratory fitness; Cardiometabolic protection
ID TERM CALORIC RESTRICTION; CARDIOVASCULAR-DISEASE; SKELETAL-MUSCLE;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; OXIDATIVE STRESS; EXERCISE;
   CAPACITY; OBESITY; MODEL
AB Background Caloric restriction and exercise are lifestyle interventions that effectively attenuate cardiometabolic impairment. However, cardioprotective effects of long-term lifestyle interventions and short-term lifestyle interventions followed by weight maintenance in prediabetes have never been compared. High cardiorespiratory fitness (CRF) has been shown to provide protection against prediabetes and cardiovascular diseases, however, the interactions between CRF, prediabetes, caloric restriction, and exercise on cardiometabolic health has never been investigated. Methods Seven-week-old male Wistar rats were fed with either a normal diet (ND; n = 6) or a high-fat diet (HFD; n = 30) to induce prediabetes for 12 weeks. Baseline CRF and cardiometabolic parameters were determined at this timepoint. The ND-fed rats were fed continuously with a ND for 16 more weeks. The HFD-fed rats were divided into 5 groups (n = 6/group) to receive one of the following: (1) a HFD without any intervention for 16 weeks, (2) 40% caloric restriction for 6 weeks followed by an ad libitum ND for 10 weeks, (3) 40% caloric restriction for 16 weeks, (4) a HFD plus an exercise training program for 6 weeks followed by a ND without exercise for 10 weeks, or (5) a HFD plus an exercise training program for 16 weeks. At the end of the interventions, CRF and cardiometabolic parameters were re-assessed. Then, all rats were euthanized and heart tissues were collected. Results Either short-term caloric restriction or exercise followed by weight maintenance ameliorated cardiometabolic impairment in prediabetes, as indicated by increased insulin sensitivity, improved blood lipid profile, improved mitochondrial function and oxidative phosphorylation, reduced oxidative stress and inflammation, and improved cardiac function. However, these benefits were not as effective as those of either long-term caloric restriction or exercise. Interestingly, high-level baseline CRF was correlated with favorable cardiac and metabolic profiles at follow-up in prediabetic rats, both with and without lifestyle interventions. Conclusions Short-term lifestyle modification followed by weight maintenance improves cardiometabolic health in prediabetes. High CRF exerted protection against cardiometabolic impairment in prediabetes, both with and without lifestyle modification. These findings suggest that targeting the enhancement of CRF may contribute to the more effective treatment of prediabetes-induced cardiometabolic impairment.
C1 [Thonusin, Chanisa; Pantiya, Patcharapong; Sumneang, Natticha; Siri-Angkul, Natthaphat; Sriwichaiin, Sirawit; Chattipakorn, Nipon] Chiang Mai Univ, Fac Med, Dept Physiol, Cardiac Electrophysiol Unit, Chiang Mai, Thailand.
   [Thonusin, Chanisa; Pantiya, Patcharapong; Sumneang, Natticha; Chunchai, Titikorn; Nawara, Wichwara; Arunsak, Busarin; Siri-Angkul, Natthaphat; Sriwichaiin, Sirawit; Chattipakorn, Siriporn C.; Chattipakorn, Nipon] Chiang Mai Univ, Fac Med, Cardiac Electrophysiol Res & Training Ctr, Chiang Mai, Thailand.
   [Thonusin, Chanisa; Pantiya, Patcharapong; Sumneang, Natticha; Chunchai, Titikorn; Nawara, Wichwara; Arunsak, Busarin; Siri-Angkul, Natthaphat; Sriwichaiin, Sirawit; Chattipakorn, Siriporn C.; Chattipakorn, Nipon] Chiang Mai Univ, Ctr Excellence Cardiac Electrophysiol Res, Chiang Mai, Thailand.
   [Chattipakorn, Siriporn C.] Chiang Mai Univ, Fac Dent, Dept Oral Biol & Diagnost Sci, Chiang Mai, Thailand.
C3 Chiang Mai University; Chiang Mai University; Chiang Mai University;
   Chiang Mai University
RP Chattipakorn, N (corresponding author), Chiang Mai Univ, Fac Med, Dept Physiol, Cardiac Electrophysiol Unit, Chiang Mai, Thailand.; Chattipakorn, N (corresponding author), Chiang Mai Univ, Fac Med, Cardiac Electrophysiol Res & Training Ctr, Chiang Mai, Thailand.; Chattipakorn, N (corresponding author), Chiang Mai Univ, Ctr Excellence Cardiac Electrophysiol Res, Chiang Mai, Thailand.
EM nchattip@gmail.com
RI Sumneang, Natticha/IST-7609-2023; Chattipakorn, Nipon/AAJ-4049-2021
OI Chattipakorn, Nipon/0000-0003-3026-718X; Chattipakorn,
   Siriporn/0000-0003-1677-7052; Siri-Angkul,
   Natthaphat/0000-0002-2776-3759; Pantiya,
   Patcharapong/0000-0002-2181-7197
FU Faculty of Medicine Chiang Mai University Endowment Fund [114-2563];
   Research Grant for New Scholars from the National Research Council of
   Thailand [RGNS 64-059]; Teaching Assistant and Research Assistant (TARA)
   Scholarship, Chiang Mai University, Thailand; Royal Golden Jubilee Ph.D.
   program; Research Grant for Talented Young Researchers from the National
   Research Council of Thailand; National Research Council of Thailand;
   National Science and Technology Development Agency Thailand; Chiang Mai
   University Center of Excellence Award
FX This study was supported by Faculty of Medicine Chiang Mai University
   Endowment Fund (114-2563: C.T.); the Research Grant for New Scholars
   from the National Research Council of Thailand (RGNS 64-059: C.T.);
   Teaching Assistant and Research Assistant (TARA) Scholarship, Chiang Mai
   University, Thailand (P.P.); the Royal Golden Jubilee Ph.D. program
   (P.P. & S.C.C.); the Research Grant for Talented Young Researchers from
   the National Research Council of Thailand (T.C.); a Senior Research
   Scholar grant from the National Research Council of Thailand (S.C.C.);
   the NSTDA Research Chair Grant from the National Science and Technology
   Development Agency Thailand (N.C.); and a Chiang Mai University Center
   of Excellence Award (N.C.)
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NR 78
TC 9
Z9 9
U1 0
U2 10
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1076-1551
EI 1528-3658
J9 MOL MED
JI Mol. Med.
PD DEC
PY 2022
VL 28
IS 1
AR 31
DI 10.1186/s10020-022-00458-9
PG 22
WC Biochemistry & Molecular Biology; Cell Biology; Medicine, Research &
   Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology; Research & Experimental
   Medicine
GA ZQ6PF
UT WOS:000767223900001
PM 35272616
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Staffini, A
   Fujita, K
   Svensson, AK
   Chung, UI
   Svensson, T
AF Staffini, Alessio
   Fujita, Kento
   Svensson, Akiko Kishi
   Chung, Ung-Il
   Svensson, Thomas
TI Statistical Methods for Item Reduction in a Representative Lifestyle
   Questionnaire: Pilot Questionnaire Study
SO INTERACTIVE JOURNAL OF MEDICAL RESEARCH
LA English
DT Article
DE item reduction; surveys and lifestyle questionnaires; feedback measures;
   questionnaire design; variance inflation factor; factor analysis; mobile
   phone
ID EXPLORATORY FACTOR-ANALYSIS; PATIENT SATISFACTION; HEALTH; STRESS;
   ALPHA; TESTS
AB Background: Reducing the number of items in a questionnaire while maintaining relevant information is important as it is associated with advantages such as higher respondent engagement and reduced response error. However, in health care, after the original design, an a posteriori check of the included items in a questionnaire is often overlooked or considered to be of minor importance. When conducted, this is often based on a single selected method. We argue that before finalizing any lifestyle questionnaire, a posteriori validation should always be conducted using multiple approaches to ensure the robustness of the results.
   Objective: The objectives of this study are to compare the results of two statistical methods for item reduction (variance inflation factor [VIF] and factor analysis [FA]) in a lifestyle questionnaire constructed by combining items from different sources and analyze the different results obtained from the 2 methods and the conclusions that can be made about the original items.
   Methods: Data were collected from 79 participants (heterogeneous in age and sex) with a high risk of metabolic syndrome working in a financial company based in Tokyo. The lifestyle questionnaire was constructed by combining items (asked with daily, weekly, and monthly frequency) from multiple validated questionnaires and other selected questions. Item reduction was conducted using VIF and exploratory FA. Adequacy tests were used to check the data distribution and sampling adequacy.
   Results: Among the daily and weekly questions, both VIF and FA identified redundancies in sleep-related items. Among the monthly questions, both approaches identified redundancies in stress-related items. However, the number of items suggested for reduction often differed: VIF suggested larger reductions than FA for daily questions but fewer reductions for weekly questions. Adequacy tests always confirmed that the structural detection was adequate for the considered items.
   Conclusions: As expected, our analyses showed that VIF and FA produced both similar and different findings, suggesting that questionnaire designers should consider using multiple methods for item reduction. Our findings using both methods indicate that many questions, especially those related to sleep, are redundant, indicating that the considered lifestyle questionnaire can be shortened.
C1 [Staffini, Alessio; Svensson, Akiko Kishi; Chung, Ung-Il; Svensson, Thomas] Univ Tokyo, Grad Sch Engn, Dept Bioengn, Precis Hlth, Tokyo, Japan.
   [Staffini, Alessio] Catholic Univ Milan, Dept Econ & Finance, Milan, Italy.
   [Staffini, Alessio] Albert Inc, Data Solut Div, Project Promot Dept, Tokyo, Japan.
   [Fujita, Kento] SoftBank Corp, Serv Infrastruct Div, IT OT Innovat Div, Mobile Technol Unit,Data Serv Infrastruct Dev Dep, Tokyo, Japan.
   [Svensson, Akiko Kishi; Svensson, Thomas] Lund Univ, Dept Clin Sci, Malmo, Sweden.
   [Svensson, Akiko Kishi] Univ Tokyo, Dept Diabet & Metab Dis, Tokyo, Japan.
   [Chung, Ung-Il; Svensson, Thomas] Kanagawa Univ Human Serv, Sch Hlth Innovat, Kawasaki, Kanagawa, Japan.
   [Chung, Ung-Il] Univ Tokyo, Ctr Dis Biol & Integrat Med, Grad Sch Med, Clin Biotechnol, Tokyo, Japan.
C3 University of Tokyo; Catholic University of the Sacred Heart; SoftBank
   Corporation; Lund University; University of Tokyo; University of Tokyo
RP Svensson, AK (corresponding author), Univ Tokyo, Grad Sch Engn, Precis Hlth, Dept Bioengn,Bunkyo Ku, 7-3-1 Hongo, Tokyo 1138656, Japan.
EM kishi@bioeng.t.u-tokyo.ac.jp
RI Svensson, Thomas/AAJ-4578-2020
OI Staffini, Alessio/0000-0001-5001-349X; Fujita, Kento/0000-0003-0186-6132
FU Center of Innovation Program of the Japan Science and Technology Agency
   [JPMJCE1304]
FX This research was supported by the Center of Innovation Program of the
   Japan Science and Technology Agency (grant number JPMJCE1304). The
   funders had no role in the design of the study; collection, analysis,
   and interpretation of data; writing of the report; or decision to submit
   the paper for publication. The authors would like to thank all staff
   members at the Center of Innovation, University of Tokyo, for their
   extensive efforts and help in conducting the study. The authors would
   also like to thank all members of Precision Health, The University of
   Tokyo, for their invaluable assistance and, in particular, Dr Masahiro
   Nakamura for his help with the preparation of the data set. The authors
   wish to thank the Nomura Securities Health Insurance Association for
   recruiting participants and collecting data. The authors also wish to
   thank Shinya Uezono (SoftBank Corp), Shunya Arita (SoftBank Corp),
   Toshiki Murata (SoftBank Corp), Saeru Yamamuro (SoftBank Corp), Tomoki
   Kinoue (SoftBank Corp), Tomihisa Ikeura (The University of Tokyo, Center
   of Innovation Program), and Yoshifumi Matsui (Albert Inc) for their
   support in this project. The authors would like to thank Tatsunori Seki
   (SoftBank Corp) and Yoshiya Shigeeda (SoftBank Corp) for their
   insightful comments and suggestions.
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NR 44
TC 14
Z9 16
U1 1
U2 9
PU JMIR PUBLICATIONS, INC
PI TORONTO
PA 130 QUEENS QUAY East, Unit 1100, TORONTO, ON M5A 0P6, CANADA
SN 1929-073X
J9 INTERACT J MED RES
JI Interact. J. Med. Res.
PD JAN-JUN
PY 2022
VL 11
IS 1
AR e28692
DI 10.2196/28692
PG 10
WC Medicine, Research & Experimental
WE Emerging Sources Citation Index (ESCI)
SC Research & Experimental Medicine
GA 1X5MX
UT WOS:000807498800006
PM 35302507
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Abdulnaby, NK
   Sayed, AO
   Shalaby, NM
AF Abdulnaby, Nasser Keshar
   Sayed, Ashraf Othman
   Shalaby, Nehad Mohamed
TI Predictive value of serum uric acid in hospitalized adolescents and
   adults with acute asthma
SO THERAPEUTICS AND CLINICAL RISK MANAGEMENT
LA English
DT Article
DE asthma; uric acid; exacerbation; spirometery
ID OBSTRUCTIVE PULMONARY-DISEASE; OXIDATIVE STRESS; XANTHINE
   OXIDOREDUCTASE; CARDIOVASCULAR RISK; NALP3 INFLAMMASOME; METABOLIC
   SYNDROME; CREATININE RATIO; UNEXPECTED ROLE; CHILDREN; MEDIATOR
AB Background: High serum uric acid (sUA) is an indicator of oxidative stress and is linked to tissue hypoxia in asthma. The objective of this case series was to investigate the prognostic role of sUA in patients with acute asthma exacerbations and the link between sUA and spirometric lung tests.
   Patients and methods: This cross-sectional observational study included 120 patients with acute asthma exacerbations and 120 controls, categorized according to peak expiratory flow rate into moderate, and severe and life-threatening asthma. On admission, a detailed history was obtained and investigations were carried out regarding oxygen saturation (SaO(2)), arterial blood gas, spirometry, sUA, number of asthma exacerbations, smoking status, history of previous hospitalization, intensive care unit admission, and mechanical ventilation.
   Results: The current study revealed higher sUA in asthmatic patients compared with healthy subjects and in severe asthma patients compared with moderate asthma patients (P<0.001). A positive correlation of sUA with asthma severity, number of asthma exacerbations and smoking index (r=0.6, 0.42 and 0.29, respectively, P<0.001) and a negative correlation of sUA with SaO(2), partial pressure of arterial oxygen (PaO2), percent predicted forced vital capacity, percent predicted forced expiratory volume (FEV%) and peak expiratory flow rate percent of predicted (PEFR%; r=-0.48, -0.29, -0.44, -0.44 and -0.66, respectively, P<0.001) were observed. Degree of asthma severity, number of asthma exacerbations, and smoking index were significant predictors of high sUA (R-2=0.43, P<0.001) in multiple linear regression model 1. SaO(2) and PEFR% were significant predictors of high uric acid (R-2=0.50, P<0.001) in model 2. The sensitivity and specificity of sUA in predicting severity of asthma at the cutoff point of 6.3 mg/dL were 80% and 90%, respectively. The odds ratios of sUA, number of asthma exacerbations, and asthma duration were 5.4, 1.95 and 1.3, respectively.
   Conclusion: sUA may be a useful marker of predictive value of severity of asthma exacerbations.
C1 [Abdulnaby, Nasser Keshar] Cairo Univ, Fac Med, Chest Dis & TB Dept, Cairo, Egypt.
   [Sayed, Ashraf Othman] Menia Univ, Children & Womens Univ Hosp, Dept Pediat, El Minya, Egypt.
   [Shalaby, Nehad Mohamed] Mansoura Univ, Childrens Hosp, Fac Med, Dept Pediat, Algomhoriah St, Mansoura 35511, Egypt.
C3 Egyptian Knowledge Bank (EKB); Cairo University; Egyptian Knowledge Bank
   (EKB); Minia University; Egyptian Knowledge Bank (EKB); Mansoura
   University
RP Shalaby, NM (corresponding author), Mansoura Univ, Childrens Hosp, Fac Med, Dept Pediat, Algomhoriah St, Mansoura 35511, Egypt.
EM amahalawy2002@yahoo.com
RI Shalaby, Naglaa/KIC-1100-2024; Keshar, Nasser/HTN-7714-2023
OI Keshar, Nasser/0000-0002-5257-3017
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NR 35
TC 17
Z9 18
U1 1
U2 6
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-203X
J9 THER CLIN RISK MANAG
JI Therap. Clin. Risk Manag.
PY 2016
VL 12
BP 1701
EP 1708
DI 10.2147/TCRM.S116188
PG 8
WC Health Care Sciences & Services
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Health Care Sciences & Services
GA EB7XR
UT WOS:000387604900001
PM 27881923
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU de la Torre, JC
AF de la Torre, Jack C.
TI Pathophysiology of neuronal energy crisis in Alzheimer's disease
SO NEURODEGENERATIVE DISEASES
LA English
DT Article; Proceedings Paper
CT 8th International Conference on Alzheimers and Parkinsons Diseases
CY MAR 14-18, 2007
CL Salzburg, AUSTRIA
DE Alzheimer's disease; brain hypoperfusion; neuronal energy metabolism;
   vascular risk factors; neuroimaging; critically attained threshold of
   cerebral hypoperfusion; aging
ID CEREBRAL-BLOOD-FLOW; NITRIC-OXIDE SYNTHASE; VASCULAR RISK-FACTORS;
   REDUCTASE INHIBITORS; METABOLIC SYNDROME; CACHE COUNTY; DEMENTIA;
   HYPOPERFUSION; STROKE; BRAIN
AB A large body of evidence indicates that sporadic Alzheimer's disease (AD) is a vascular disorder with neurodegenerative consequences and needs to be treated and managed as such. Epidemiologic studies of vascular risk factors, together with preclinical detection tools for AD are proof of concept that cerebral hypoperfusion is one of the earliest pathological signs in the development of cognitive failure. Vascular risk factors involving heart disease and stroke in the elderly individual who already possesses a dwindling cerebrovascular reserve due to advancing age contribute to further decline in cerebral blood flow (CBF) resulting in unrelenting brain hypoperfusion. Brain hypoperfusion, in turn, can reach a critically attained threshold of cerebral hypoperfusion (CATCH) giving rise to a neuronal energy crisis via reduced ATP synthesis. The ensuing metabolic energy crisis initially carves up ischemic-sensitive neurons in the hippocampus and posterior parietal cortex setting up cognitive meltdown and progressive neuroclegenerative and atrophic changes in the brain. Neuronal energy compromise accelerates oxidative stress, excess production of reactive oxygen species, aberrant protein synthesis, ionic membrane pump dysfunction, signal transduction impairment, neurotransmitter failure,abnormal processing of amyloid precursor protein resulting in P-amyloid deposition and axonal microtubule disruption from tau hyperphosphorylation. The high energy metabolic changes leading to oxidative stress and cellular hypometabolism precede clinical expression of AD. Regional CBF measurements using neuroimaging techniques can predict AD preclinically at the mild cognitive impairment stage or even before any clinical manifestation of dementia is expressed. Clinical diagnostic assessment of elderly persons who could develop or already present with memory complaints can prevent, reverse or slow down AD development. Although pathologic aging is the subject of thousands of studies, the question of why the elderly (and not younger people) succumb to AD has not been adequately addressed. The explanation(s) as to why vascular risk factors, for example, can trigger AD or vascular dementia usually in the elderly and not the young should provide vital clues in the search for a strategically effective dementia treatment. This review offers inductive hypothetical darts relative to that critical question. Copyright (c) 2008 S. Karger AG, Basel.
C1 [de la Torre, Jack C.] Case Western Reserve Univ, Sch Med, Inst Pathol, Cleveland, OH 44106 USA.
C3 University System of Ohio; Case Western Reserve University
RP de la Torre, JC (corresponding author), 3416 80th Ave Ct NW,Suite 100, Gig Harbor, WA 98335 USA.
EM jcdelatorre@comcast.net
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NR 39
TC 112
Z9 124
U1 0
U2 12
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1660-2854
EI 1660-2862
J9 NEURODEGENER DIS
JI Neurodegener. Dis.
PY 2008
VL 5
IS 3-4
BP 126
EP 132
DI 10.1159/000113681
PG 7
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Neurosciences & Neurology
GA 275ZA
UT WOS:000254109700005
PM 18322369
DA 2025-06-11
ER

PT J
AU Kumar, AM
   Solano, MP
   Fernandez, JB
   Kumar, M
AF Kumar, AM
   Solano, MP
   Fernandez, JB
   Kumar, M
TI Adrenocortical response to ovine corticotropin-releasing hormone in
   young men: Cortisol measurement in matched samples of saliva and plasma
SO HORMONE RESEARCH
LA English
DT Article
DE saliva; plasma; cortisol; corticotropin-releasing hormone
ID PITUITARY-ADRENAL AXIS; DIRECT RADIOIMMUNOASSAY; METABOLIC SYNDROME;
   STRESS; CORTICOSTEROIDS; DISORDER; OBESITY; RHYTHM; SERUM; FLUID
AB Background: Assessment of hypothalamic-pituitary-adrenal (HPA) axis function in stress-related health problems in humans is frequently carried out as a dynamic test by measuring the profile of increment in adrenocortical hormone (ACTH) and/or cortisol level in plasma in response to corticotropin-releasing hormone (CRH) administration. However, obtaining multiple blood samples for this type of test is not only an invasive procedure but also problematic to use in individuals with constricted or damaged veins which collapse during the blood draw such as the injecting drug users (IDUs) and HIV-1-infected individuals. Salivary cortisol measurement presents a non-invasive alternate approach to evaluate HPA axis activity in different situations. In order to validate the efficacy of salivary cortisol measurement for a dynamic test in IDUs and HIV-1-infected individuals, the present study was carried out to evaluate the cortisol profile in matched samples of plasma and saliva in healthy young men in response to ovine CRH (oCRH) administration. Methods: Cortisol levels were measured in matched samples of plasma and saliva of healthy young men at baseline and over a 90-min period after administration of a single low dose of oCRH (1 mu g/kg). Results: Salivary cortisol levels were found to follow the profile similar to that of plasma, increasing significantly at each time point after oCRH administration from their respective baseline values (all Sign tests, p < 0.05). The peak level of cortisol occurred at 30 min in both fluids. Although salivary cortisol concentration was a fraction of the total plasma cortisol levels at all time points, there was a significant correlation in the values between the two fluids at baseline (r = 0.87, p < 0.02) as well as at 90 min ( r = 0.70, p < 0.03). Conclusion: The findings support the earlier studies and substantiate the efficacy of using salivary free cortisol measurement for assessment of dynamic function of pituitary-adrenal axis in healthy young men and its application in individuals such as IDUs and HIV-infected individuals who may have difficulty in donating multiple blood samples. Copyright (C) 2005 S. Karger AG, Basel.
C1 Univ Miami, Miller Sch Med, Dept Psychiat & Behav Sci, Div Diabet,Res Inst, Miami, FL 33101 USA.
   Univ Miami, Miller Sch Med, Dept Psychol, Div Diabet,Res Inst, Miami, FL 33101 USA.
   Univ Miami, Miller Sch Med, Dept Med, Div Diabet,Res Inst, Miami, FL 33101 USA.
C3 University of Miami; University of Miami; University of Miami
RP Univ Miami, Miller Sch Med, Dept Psychiat & Behav Sci, Div Diabet,Res Inst, POB 016960, Miami, FL 33101 USA.
EM akumar@med.miami.edu
RI SOLANO, PARDINA/T-2986-2019
FU NIDA NIH HHS [R01 DA13550, R01 DA12792] Funding Source: Medline
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NR 41
TC 11
Z9 12
U1 0
U2 3
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0301-0163
EI 1663-2826
J9 HORM RES
JI Horm. Res.
PY 2005
VL 64
IS 2
BP 55
EP 60
DI 10.1159/000087381
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 972YN
UT WOS:000232489800001
PM 16103684
DA 2025-06-11
ER

PT J
AU Zhong, Q
   Ren, L
   Wang, TH
   An, ZM
   Hua, YS
AF Zhong, Qian
   Ren, Li
   Wang, Tianhong
   An, Zhenmei
   Hua, Yusi
TI The association between circadian syndrome and possible sarcopenia in an
   aging population: A 4-year follow-up study
SO PLOS ONE
LA English
DT Article
ID OBSTRUCTIVE SLEEP-APNEA; LOW MUSCLE MASS; METABOLIC SYNDROME;
   SKELETAL-MUSCLE; AEROBIC FITNESS; DURATION; OBESITY; CLOCK; HEALTH;
   ORGANIZATION
AB Introduction Recently, circadian syndrome (CircS) is proposed as a novel risk cluster based on sleep disorder, depression, dyslipidemia, hyperglycemia, hypertension and abdominal obesity. To investigate the association between CircS and possible sarcopenia, this study was performed. Methods Possible sarcopenia is defined according to Asian Working Group for Sarcopenia in 2019, which includes measures of muscle strength and physical performance. In the baseline survey, 7,905 participants aged >= 40 years from the China Health and Retirement Longitudinal Study were included. Multivariate logistic regression was used to evaluate the association between CircS and possible sarcopenia. Subgroup and interactive analyses were adopted to verify the findings in the overall population and identify potential interactive effects. The obese population was excluded and the missing values were interpolated using multivariate imputation by chained equations as sensitivity analyses. In addition, the participants were followed up for four years to explore the longitudinal association between CircS and incident possible sarcopenia. Results As per one increase of CircS components, participants had a 1.11-fold (95% CI = 1.07-1.14, P < 0.001) risk of prevalent possible sarcopenia in the full model. The CircS group was associated with a 1.30-fold (95% CI = 1.17-1.44) risk of prevalent possible sarcopenia (P < 0.001). No significant interactive effects of covariates on the association between CircS and prevalent possible sarcopenia were detected (all P for interaction > 0.05). All the subgroup and sensitivity analyses supported the positive association between CircS and possible sarcopenia. In the longitudinal follow-up, the odd ratio was 1.06 (95% CI = 1.00-1.13, P < 0.05) as per one increase of CircS components in the full model. The CircS group was also found to have an elevated risk of incident possible sarcopenia (odd ratio = 1.24, 95% CI = 1.03-1.50, P < 0.05) after adjusting all the covariates. Conclusions CircS is a risk factor for possible sarcopenia, which may serve as a predictor of possible sarcopenia for early identification and intervention.
C1 [Zhong, Qian; Wang, Tianhong; An, Zhenmei] Sichuan Univ, West China Hosp, Dept Endocrinol, Chengdu, Peoples R China.
   [Ren, Li] Sichuan Univ, West China Hosp, Dept Gen Surg, Div Vasc Surg, Chengdu, Peoples R China.
   [Wang, Tianhong] Sichuan Univ, West China Hosp, Dept Clin Res, Chengdu, Peoples R China.
   [Hua, Yusi] Sichuan Univ, West China Hosp, Dept Anesthesiol, Chengdu, Sichuan, Peoples R China.
C3 Sichuan University; Sichuan University; Sichuan University; Sichuan
   University
RP An, ZM (corresponding author), Sichuan Univ, West China Hosp, Dept Endocrinol, Chengdu, Peoples R China.; Hua, YS (corresponding author), Sichuan Univ, West China Hosp, Dept Anesthesiol, Chengdu, Sichuan, Peoples R China.
EM azmhxnfm@163.com; yusihua@wchscu.cn
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NR 71
TC 0
Z9 0
U1 0
U2 0
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PY 2025
VL 20
IS 5
AR e0323211
DI 10.1371/journal.pone.0323211
PG 16
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 2QG1N
UT WOS:001488721000011
PM 40359225
OA gold
DA 2025-06-11
ER

PT J
AU Ahn, Y
   Lee, Y
   Park, H
   Song, K
AF Ahn, Yoonjin
   Lee, Youngmi
   Park, Haeryun
   Song, Kyunghee
TI Gender and age group differences in nutrition intake and dietary quality
   of Korean adults eating alone: based on Korean National Health and
   Nutrition Examination Survey Data, 2013-2016
SO NUTRITION RESEARCH AND PRACTICE
LA English
DT Article
DE Eating alone; gender; age groups; nutrition intake; dietary quality
ID METABOLIC SYNDROME; ASSOCIATION; POPULATION; DEPRESSION; VALIDITY; RISK
AB BACKGROUND/OBJECTIVES: This study investigated gender and age differences in nutrient intake and dietary quality of people eating alone.
   SUBJECTS/METHODS: From Korean National Health and Nutrition Examination Survey 2013-2016 data, 2,305 adults aged 20 years and older that ate meals alone were included in this study. Their energy and nutrients intakes, as well as their nutrient adequacy ratio (NAR mean adequacy ratio (MAR), and index of nutritional quality (INQ) were analyzed. Food group consumption pattern, dietary variety score (DVS), dietary diversity score (DDS) were also analyzed. All data were compared among gender and age groups.
   RESULTS: Men consumed more energy and nutrients than women, except for vitamin C, and the NAR5 showed similar gender differences. The INQs of 4 nutrients (calcium, vitamin A, vitamin C, and riboflavin) were lower than 1.0 in men, whereas only the calcium INQ was lower than 1.0 in women. Men had a lower DDS (3.6) than women (3.9) (P< 0.001) and had more 'undesirable' food group consumption patterns than women (P< 0.001). The intakes of calcium, vitamin A, and vitamin C were relatively low in the young-aged group (INQs less than 1.0). In the old-aged group, the MAR level was relatively low, and the INQs of calcium, riboflavin, and niacin were below 1.0. The old-aged group consumed more menu items, but their DVS was the lowest.
   CONCLUSIONS: Compared to women, the dietary quality and food diversity among men were poorer. There were poorer quality and diversity patterns in the young-aged group compared to those of the older groups. An overall low intake of nutrients and the low nutrient density of meals were the main dietary problems among the old-aged group who eat alone. Therefore, men, particularly young- and old-aged, need to be prioritized in nutritional policies directed toward those who eat alone.
C1 [Ahn, Yoonjin; Lee, Youngmi; Park, Haeryun; Song, Kyunghee] Myongji Univ, Dept Food & Nutr, 116 Myongji Ro, Yongin 17058, South Korea.
C3 Myongji University
RP Lee, Y (corresponding author), Myongji Univ, Dept Food & Nutr, 116 Myongji Ro, Yongin 17058, South Korea.
EM zeromi@mju.ac.kr
OI AHN, YOONJIN/0000-0002-7977-0715; Song, Kyunghee/0000-0001-9549-0716
CR An HK, 2015, THESIS
   [Anonymous], 2015, Media and Education
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NR 38
TC 11
Z9 11
U1 1
U2 7
PU KOREAN NUTRITION SOC
PI SEOUL
PA 804 KST CTR, 635-4 YEOGSAM-SONG KANGNAM-KU, SEOUL, 135-703, SOUTH KOREA
SN 1976-1457
EI 2005-6168
J9 NUTR RES PRACT
JI Nutr. Res. Pract.
PD FEB
PY 2021
VL 15
IS 1
BP 66
EP 79
DI 10.4162/nrp.2021.15.1.66
PG 14
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA PW0OC
UT WOS:000610375900006
PM 33542793
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Kushwaha, V
   Rai, P
   Varshney, S
   Gupta, S
   Khandelwal, N
   Kumar, D
   Gaikwad, AN
AF Kushwaha, Vinita
   Rai, Prashant
   Varshney, Salil
   Gupta, Sanchita
   Khandelwal, Nilesh
   Kumar, Durgesh
   Gaikwad, Anil Nilkanth
TI Sodium butyrate reduces endoplasmic reticulum stress by modulating CHOP
   and empowers favorable anti-inflammatory adipose tissue
   immune-metabolism in HFD fed mice model of obesity
SO FOOD CHEMISTRY: MOLECULAR SCIENCES
LA English
DT Article
DE SCFA; ER stress; Adipose tissue; Immune cell population; Obesity
ID GUT MICROBIOTA; ER STRESS; ENERGY-EXPENDITURE; T-CELLS; INFLAMMATION;
   MACROPHAGES; INDUCTION; TRANSPORT; PROTEIN; ACID
AB Over the past decade, the gut microbiome has been linked to several diseases including gastrointestinal diseases, cancer, immune disorder and metabolic syndrome. Shifts in the gut bacterial population affect the overall metabolic health status leading towards obesity and Type II diabetes mellitus. Secondary metabolites secreted by the gut microbiome interact with various host-sensing signalling pathways and are responsible for functional modulation of immune resident cells in metabolic tissues (Bluher, 2019). Of these, short- chain fatty acids (SCFAs) i.e., acetate, propionate and butyrate have been significantly correlated with the disposition of diabetes and metabolic disorder. The altered gut microbial population depletes the intestinal barrier causing entry of LPS into circulation and towards metabolic tissues triggering pro-inflammatory responses. As butyrate has been known to maintain intestinal integrity, we aimed to assess the apparent effect of externally given sodium butyrate [NaB] on immuno-metabolic profiling of adipose tissue, and its association with metabolic and inflammatory status of adipose tissue. To assess this, we put groups of C57BL/6 mice i.e., Control fed with a regular chow diet and another group that was fed on a high fat diet (HFD, 60%) for 8 weeks. Following this, the HFD group were further subdivided into two groups one fed with HFD and the other with HFD + NaB (5%w/w) for another 8 weeks. Body composition, weight gain, body adiposity and biochemical parameters were assessed. NaB fed group showed an improved metabolic profile compared to HFD fed group. Administration of NaB also improved glucose tolerance capacity and insulin sensitivity as determined by IPGTT and ITT profiles. Earlier reports have shown gut leakage and increased LPS in circulation is the primary cause of setting up inflammation at the tissue level. Our studies exhibited that, NaB increased the expression of tight junction proteins of intestinal linings and thereby enhanced intestinal barrier integrity. The FITC dextran permeability assay further confirmed this enhanced intestinal barrier integrity. We assessed the quantitative and relative population of different types of resident immune cells from a stromal vascular fraction of adipose tissue. Flow cytometry studies revealed significantly increased M2 (CD206+ ) macrophages and Tregs (CD25+ ) relative to the M1 macrophage population and CD4+ T cells respectively in NaB treated mice, suggesting its potential role in alleviating the inflammatory profile. In a nutshell, taken together better glucose tolerance, better gut health, reduced inflammatory adipose tissue immune cells, suggest potential beneficial role of sodium butyrate in alleviating overall inflammation and metabolic dysfunction associated with obesity.
C1 [Kushwaha, Vinita; Rai, Prashant; Varshney, Salil; Gupta, Sanchita; Khandelwal, Nilesh; Kumar, Durgesh; Gaikwad, Anil Nilkanth] CSIR Cent Drug Res Inst, Div Pharmacol, Lucknow 226031, Uttar Pradesh, India.
   [Kushwaha, Vinita; Varshney, Salil; Gupta, Sanchita; Khandelwal, Nilesh; Kumar, Durgesh; Gaikwad, Anil Nilkanth] CSIR HRDG, Acad Sci & Innovat Res AcSIR Headquarters, Campus Sect 19, Ghaziabad 201002, UP, India.
C3 Council of Scientific & Industrial Research (CSIR) - India; CSIR -
   Central Drug Research Institute (CDRI)
RP Gaikwad, AN (corresponding author), CSIR Cent Drug Res Inst, Div Pharmacol, Lucknow 226031, Uttar Pradesh, India.
EM anil_gaikwad@cdri.res.in
RI Varshney, Salil/JBI-8723-2023; Khandelwal, Nilesh/NIS-6271-2025
OI KHANDELWAL, NILESH/0000-0002-9155-0651; Kumar,
   Durgesh/0009-0001-7413-3987; Rai, Prashant/0009-0009-6866-8596
FU SRF-DBT; CSIR-CDRI project; SRF-CSIR; SRF-ICMR; SRF-UGC
FX This research work is supported by CSIR-CDRI project. KV, NK and DK are
   supported by SRF-CSIR.SG is supported by SRF-DBT. SV is sup-ported by
   SRF-ICMR. PR is supported by SRF-UGC. This manuscript bears CSIR-CDRI
   communication number-10357.
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NR 34
TC 26
Z9 27
U1 1
U2 14
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2666-5662
J9 FOOD CHEM-MOL SCI
JI Food Chem.-Mol. Sci.
PD JUL 30
PY 2022
VL 4
AR 100079
DI 10.1016/j.fochms.2022.100079
EA FEB 2022
PG 11
WC Food Science & Technology
WE Emerging Sources Citation Index (ESCI)
SC Food Science & Technology
GA 0Z3WM
UT WOS:000791011300002
PM 35415672
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Kraemer, WJ
   Ratamess, NA
   Hymer, WC
   Nindl, BC
   Fragala, MS
AF Kraemer, William J.
   Ratamess, Nicholas A.
   Hymer, Wesley C.
   Nindl, Bradley C.
   Fragala, Maren S.
TI Growth Hormone(s), Testosterone, Insulin-Like Growth Factors, and
   Cortisol: Roles and Integration for Cellular Development and Growth With
   Exercise
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Review
DE anabolic; catabolic; protein synthesis; skeletal muscle; endocrine;
   glucocorticoid; androgen; signaling
ID GLUCOCORTICOID-RECEPTOR-BETA; HEAVY-RESISTANCE EXERCISE; HUMAN
   SKELETAL-MUSCLE; MAMMOTROPH SECRETORY GRANULES; MESSENGER-RNA
   EXPRESSION; CAG REPEAT POLYMORPHISM; SEX STEROID-HORMONES; FAT-FREE
   MASS; ANDROGEN RECEPTOR; IGF-I
AB Hormones are largely responsible for the integrated communication of several physiological systems responsible for modulating cellular growth and development. Although the specific hormonal influence must be considered within the context of the entire endocrine system and its relationship with other physiological systems, three key hormones are considered the "anabolic giants" in cellular growth and repair: testosterone, the growth hormone superfamily, and the insulin-like growth factor (IGF) superfamily. In addition to these anabolic hormones, glucocorticoids, mainly cortisol must also be considered because of their profound opposing influence on human skeletal muscle anabolism in many instances. This review presents emerging research on: (1) Testosterone signaling pathways, responses, and adaptations to resistance training; (2) Growth hormone: presents new complexity with exercise stress; (3) Current perspectives on IGF-I and physiological adaptations and complexity these hormones as related to training; and (4) Glucocorticoid roles in integrated communication for anabolic/catabolic signaling. Specifically, the review describes (1) Testosterone as the primary anabolic hormone, with an anabolic influence largely dictated primarily by genomic and possible non-genomic signaling, satellite cell activation, interaction with other anabolic signaling pathways, upregulation or downregulation of the androgen receptor, and potential roles in co-activators and transcriptional activity; (2) Differential influences of growth hormones depending on the "type" of the hormone being assayed and the magnitude of the physiological stress; (3) The exquisite regulation of IGF-1 by a family of binding proteins (IGFBPs 1-6), which can either stimulate or inhibit biological action depending on binding; and (4) Circadian patterning and newly discovered variants of glucocorticoid isoforms largely dictating glucocorticoid sensitivity and catabolic, muscle sparing, or pathological influence. The downstream integrated anabolic and catabolic mechanisms of these hormones not only affect the ability of skeletal muscle to generate force; they also have implications for pharmaceutical treatments, aging, and prevalent chronic conditions such as metabolic syndrome, insulin resistance, and hypertension. Thus, advances in our understanding of hormones that impact anabolic: catabolic processes have relevance for athletes and the general population, alike.
C1 [Kraemer, William J.] Ohio State Univ, Dept Human Sci, Columbus, OH 43210 USA.
   [Ratamess, Nicholas A.] Coll New Jersey, Dept Hlth & Exercise Sci, Ewing, NJ USA.
   [Hymer, Wesley C.] Penn State Univ, Biochem & Mol Biol, University Pk, PA 16802 USA.
   [Nindl, Bradley C.] Univ Pittsburgh, Sch Hlth & Rehabil Sci, Dept Sports Med, Pittsburgh, PA USA.
   [Fragala, Maren S.] Quest Diagnost, Secaucus, NJ USA.
C3 University System of Ohio; Ohio State University; College of New Jersey;
   Pennsylvania Commonwealth System of Higher Education (PCSHE);
   Pennsylvania State University; Pennsylvania State University -
   University Park; Penn State Behrend; Pennsylvania Commonwealth System of
   Higher Education (PCSHE); University of Pittsburgh; Quest Diagnostics
   Inc
RP Kraemer, WJ (corresponding author), Ohio State Univ, Dept Human Sci, Columbus, OH 43210 USA.
EM kraemer.44@osu.edu
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NR 238
TC 170
Z9 185
U1 1
U2 35
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD FEB 25
PY 2020
VL 11
AR 33
DI 10.3389/fendo.2020.00033
PG 25
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA LC3GR
UT WOS:000525213800001
PM 32158429
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Garcia-Jaramillo, M
   Spooner, MH
   Löhr, CV
   Wong, CP
   Zhang, WJ
   Jump, DB
AF Garcia-Jaramillo, Manuel
   Spooner, Melinda H.
   Lohr, Christiane V.
   Wong, Carmen P.
   Zhang, Weijian
   Jump, Donald B.
TI Lipidomic and transcriptomic analysis of western diet-induced
   nonalcoholic steatohepatitis (NASH) in female LdIr<SUP>-/-</SUP>
   mice
SO PLOS ONE
LA English
DT Article
ID FATTY LIVER-DISEASE; MASS-SPECTROMETRIC ANALYSIS; HEPATIC STEATOSIS;
   DOCOSAHEXAENOIC ACID; METABOLIC SYNDROME; AMERICAN ASSOCIATION; PRACTICE
   GUIDELINE; ARACHIDONIC-ACID; NATURAL-HISTORY; SEX-DIFFERENCES
AB Background
   Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide, particularly in obese and type 2 diabetic individuals. NAFLD ranges in severity from benign steatosis to nonalcoholic steatohepatitis (NASH); and NASH can progress to cirrhosis, primary hepatocellular carcinoma (HCC) and liver failure. As such, NAFLD has emerged as a major public health concern. Herein, we used a lipidomic and transcriptomic approach to identify lipid markers associated with western diet (WD) induced NASH in female mice.
   Methods
   Female mice (low-density lipoprotein receptor null (LdIr(-/-)) were fed a reference or WD diet for 38 and 46 weeks. Transcriptomic and lipidomic approaches, coupled with statistical analyses, were used to identify associations between major NASH markers and transcriptomic & lipidomic markers.
   Results
   The WD induced all major hallmarks of NASH in female Ldlr(-/-)r mice, including steatosis (SFA, MUFA, MUFA-containing di- and triacylglycerols), inflammation (TNF alpha), oxidative stress (Ncf2), and fibrosis (Coll A). The WD also increased transcripts associated with membrane remodeling (LpCat), apoptosis & autophagy (Caspl, CtsS), hedgehog (Taz) & notch signaling (Hey1), epithelial-mesenchymal transition (S1004A) and cancer (Gpc3). WD feeding, however, suppressed the expression of the hedgehog inhibitory protein (Hhip), and enzymes involved in triglyceride catabolism (Tgh/Ces3, Ces1 g), as well as the hepatic abundance of C18-22 PUFA-containing phosphoglycerolipids (GpCho, GpEtn, GpSer, Gpins). WD feeding also increased hepatic cyclooxygenase (Cox1 & 2) expression and pro-inflammatory omega 6 PUFA-derived oxylipins (PGE2), as well as lipid markers of oxidative stress 8-iso-PGF2 alpha). The WD suppressed the hepatic abundance of reparative oxylipins (19, 20-DiHDPA) as well as the expression of enzymes involved in fatty epoxide metabolism (Cyp2C, Ephx).
   Conclusion
   WD-induced NASH in female LdIr(-/-) mice was characterized by a massive increase in hepatic neutral and membrane lipids containing SFA and MUFA and a loss of C18-22 PUFA-containing membrane lipids. Moreover, the WD increased hepatic pro-inflammatory oxylipins and suppressed the hepatic abundance of reparative oxylipins. Such global changes in the type and abundance of hepatic lipids likely contributes to tissue remodeling and NASH severity.
C1 [Garcia-Jaramillo, Manuel; Spooner, Melinda H.; Wong, Carmen P.; Jump, Donald B.] Oregon State Univ, Sch Biol & Populat Hlth Sci, Nutr Program, Corvallis, OR 97331 USA.
   [Garcia-Jaramillo, Manuel; Spooner, Melinda H.; Wong, Carmen P.; Zhang, Weijian; Jump, Donald B.] Oregon State Univ, Linus Pauling Inst, Corvallis, OR 97331 USA.
   [Garcia-Jaramillo, Manuel] Oregon State Univ, Dept Chem, Gilbert Hall 153, Corvallis, OR 97331 USA.
   [Lohr, Christiane V.] Oregon State Univ, Carlson Coll Vet Med, Anat Pathol, Corvallis, OR 97331 USA.
C3 Oregon State University; Oregon State University; Oregon State
   University; Oregon State University
RP Jump, DB (corresponding author), Oregon State Univ, Sch Biol & Populat Hlth Sci, Nutr Program, Corvallis, OR 97331 USA.; Jump, DB (corresponding author), Oregon State Univ, Linus Pauling Inst, Corvallis, OR 97331 USA.
EM Donald.Jump@oregonstate.edu
RI Zhang, Xiwen/JDW-3475-2023; Löhr, C./AAU-4902-2020
OI Spooner, Melinda/0000-0002-7099-1837; Lohr,
   Christiane/0000-0003-3787-5583; Garcia-Jaramillo,
   Manuel/0000-0003-2987-2913
FU National Institutes of Health (NIH) [DK094600, DK112360]; Linus Pauling
   Institute (LPI) at Oregon State University; National Institutes of
   Health [NIH 1S10RR022589-01, NIH 1S10RR027878-01]
FX This study was funded by grants from the National Institutes of Health
   (NIH) to DBJ (DK094600 and DK112360). Additionally, WZ was the recipient
   of discretionary funds from the Linus Pauling Institute (LPI) at Oregon
   State University. The Oregon State University Mass Spectrometry Center
   received the following instrumentation grants from the National
   Institutes of Health for instruments used in this study: NIH
   1S10RR022589-01 [Applied Biosystems 4000 Qtrap] and NIH 1S10RR027878-01
   [ABSciex TripleToF 5600]. The funders had no role in the study design,
   data collection and analysis, decision to publish or preparation of the
   manuscript. Competing interests: The authors have declared
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NR 109
TC 44
Z9 44
U1 4
U2 15
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD APR 3
PY 2019
VL 14
IS 4
AR e0214387
DI 10.1371/journal.pone.0214387
PG 37
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA HR5NS
UT WOS:000463194300034
PM 30943218
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Basaranoglu, M
   Basaranoglu, G
   Sabuncu, T
   Sentürk, H
AF Basaranoglu, Metin
   Basaranoglu, Gokcen
   Sabuncu, Tevfik
   Senturk, Hakan
TI Fructose as a key player in the development of fatty liver disease
SO WORLD JOURNAL OF GASTROENTEROLOGY
LA English
DT Article
DE Nonalcoholic; Fatty liver; Diabetes; Insulin resistance; Cytokines;
   Obesity; Fructose
ID DE-NOVO LIPOGENESIS; INSULIN-RESISTANCE; OXIDATIVE STRESS; METABOLIC
   SYNDROME; NONALCOHOLIC STEATOHEPATITIS; CRYPTOGENIC CIRRHOSIS;
   GLUCOSE-METABOLISM; RISK-FACTORS; WEIGHT-GAIN; OBESITY
AB We aimed to investigate whether increased consumption of fructose is linked to the increased prevalence of fatty liver. The prevalence of nonalcoholic steatohepatitis (NASH) is 3% and 20% in nonobese and obese subjects, respectively. Obesity is a low-grade chronic inflammatory condition and obesity-related cytokines such as interleukin-6, adiponectin, leptin, and tumor necrosis factor-a may play important roles in the development of nonalcoholic fatty liver disease (NAFLD). Additionally, the prevalence of NASH associated with both cirrhosis and hepatocellular carcinoma was reported to be high among patients with type 2 diabetes with or without obesity. Our research group previously showed that consumption of fructose is associated with adverse alterations of plasma lipid profiles and metabolic changes in mice, the American Lifestyle-Induced Obesity Syndrome model, which included consumption of a high-fructose corn syrup in amounts relevant to that consumed by some Americans. The observation reinforces the concerns about the role of fructose in the obesity epidemic. Increased availability of fructose (e. g., high-fructose corn syrup) increases not only abnormal glucose flux but also fructose metabolism in the hepatocyte. Thus, the anatomic position of the liver places it in a strategic buffering position for absorbed carbohydrates and amino acids. Fructose was previously accepted as a beneficial dietary component because it does not stimulate insulin secretion. However, since insulin signaling plays an important role in central mechanisms of NAFLD, this property of fructose may be undesirable. Fructose has a selective hepatic metabolism, and provokes a hepatic stress response involving activation of c-Jun N-terminal kinases and subsequent reduced hepatic insulin signaling. As high fat diet alone produces obesity, insulin resistance, and some degree of fatty liver with minimal inflammation and no fibrosis, the fast food diet which includes fructose and fats produces a gene expression signature of increased hepatic fibrosis, inflammation, endoplasmic reticulum stress and lipoapoptosis. Hepatic de novo lipogenesis (fatty acid and triglyceride synthesis) is increased in patients with NAFLD. Stable-isotope studies showed that increased de novo lipogenesis (DNL) in patients with NAFLD contributed to fat accumulation in the liver and the development of NAFLD. Specifically, DNL was responsible for 26% of accumulated hepatic triglycerides and 15%-23% of secreted very low-density lipoprotein triglycerides in patients with NAFLD compared to an estimated less than 5% DNL in healthy subjects and 10% DNL in obese people with hyperinsulinemia. In conclusion, understanding the underlying causes of NAFLD forms the basis for rational preventive and treatment strategies of this major form of chronic liver disease. (C) 2013 Baishideng. All rights reserved.
C1 [Basaranoglu, Metin; Senturk, Hakan] Bezmialem Vakif Univ, Dept Gastroenterol & Hepatol, TR-34400 Istanbul, Turkey.
   [Basaranoglu, Gokcen] Bezmialem Vakif Univ, Dept Anaesthesiol, TR-34400 Istanbul, Turkey.
   [Sabuncu, Tevfik] Harran Univ, Dept Endocrinol, TR-68000 Sanliurfa, Turkey.
C3 Bezmialem Vakif University; Bezmialem Vakif University; Harran
   University
RP Basaranoglu, M (corresponding author), Bezmialem Vakif Univ, Dept Gastroenterol & Hepatol, TR-34400 Istanbul, Turkey.
EM metin_basaranoglu@yahoo.com
RI Basaranoglu, Metin/X-2412-2018; Sabuncu, Tevfik/ABF-5291-2020;
   Başaranoğlu, Gökçen/ACW-4590-2022
OI Basaranoglu, Gokcen/0000-0002-3093-9049
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NR 59
TC 172
Z9 190
U1 0
U2 108
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 8226 REGENCY DR, PLEASANTON, CA 94588 USA
SN 1007-9327
EI 2219-2840
J9 WORLD J GASTROENTERO
JI World J. Gastroenterol.
PD FEB 28
PY 2013
VL 19
IS 8
BP 1166
EP 1172
DI 10.3748/wjg.v19.i8.1166
PG 7
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 098CE
UT WOS:000315521700003
PM 23482247
OA Green Submitted, Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Luciano, M
   Sampogna, G
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   Calcagno, P
   Carmassi, C
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AF Luciano, Mario
   Sampogna, Gaia
   Amore, Mario
   Andriola, Ileana
   Calcagno, Pietro
   Carmassi, Claudia
   Del Vecchio, Valeria
   Dell'Osso, Liliana
   Di Lorenzo, Giorgio
   Gelao, Barbara
   Giallonardo, Vincenzo
   Rossi, Alessandro
   Rossi, Rodolfo
   Siracusano, Alberto
   Fiorillo, Andrea
CA LIFESTYLE Working Grp
TI How to improve the physical health of people with severe mental illness?
   A multicentric randomized controlled trial on the efficacy of a
   lifestyle group intervention
SO EUROPEAN PSYCHIATRY
LA English
DT Article
DE Comorbidity; HOMA-IR index; Framingham risk score; RCT; BMI; waist
   circumference; severe mental disorders; lifestyle
ID BIPOLAR I DISORDER; PSYCHOEDUCATIONAL FAMILY INTERVENTION; CONSENSUS
   COGNITIVE BATTERY; FOLLOW-UP; TRANSDIAGNOSTIC PSYCHIATRY; ANTIPSYCHOTIC
   TREATMENT; CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; RISK-FACTORS;
   WEIGHT-GAIN
AB Background People with severe mental illnesses (SMI) have a mortality rate two times higher compared to the general population, with a decade of years of life lost. In this randomized controlled trial (RCT), we assessed in a sample of people with bipolar disorder, major depressive disorder, and schizophrenia spectrum disorder, the efficacy of an innovative psychosocial group intervention compared to a brief psychoeducational group intervention on patients' body mass index (BMI), body weight, waist circumference, Framingham and HOMA-IR indexes. Methods This is a multicentric RCT with blinded outcome assessments carried out in six Italian university centers. After recruitment patients were randomized to receive a 6-month psychosocial intervention to improve patients' physical health or a brief psychoeducational intervention. All recruited patients were assessed with standardized assessment instruments at baseline and after 6 months. Anthropometric parameters and blood samples have also been collected. Results Four-hundred and two patients with a diagnosis of bipolar disorder (43.3%), schizophrenia or other psychotic disorder (29.9%), or major depression (26.9%) were randomly allocated to the experimental (N = 206) or the control group (N = 195). After 6 months, patients from the experimental group reported a significant reduction in BMI (odds ratio [OR]: 1.93, 95% confidence intervals [CI]: 1.31-2.84; p < 0.001), body weight (OR = 4.78, 95% CI: 0.80-28.27, p < 0.05), and waist circumference (OR = 5.43, 95% CI: 1.45-20.30, p < 0.05). Participants with impaired cognitive and psychosocial functioning had a worse response to the intervention. Conclusions The experimental group intervention was effective in improving the physical health in SMI patients. Further studies are needed to evaluate the feasibility of this intervention in real-world settings.
C1 [Luciano, Mario; Sampogna, Gaia; Del Vecchio, Valeria; Giallonardo, Vincenzo; Fiorillo, Andrea] Univ Campania L Vanvitelli, Dept Psychiat, Naples, Italy.
   [Amore, Mario; Calcagno, Pietro] Univ Genoa, Dept Neurosci Ophthalmol Genet & Infant Maternal, Sect Psychiat, Genoa, Italy.
   [Andriola, Ileana; Gelao, Barbara] Univ Bari Aldo Moro, Dept Basic Med Sci Neurosci & Sense Organs, Bari, Italy.
   [Carmassi, Claudia; Dell'Osso, Liliana] Univ Pisa, Dept Clin & Expt Med, Pisa, Italy.
   [Di Lorenzo, Giorgio; Siracusano, Alberto] Univ Roma Tor Vergata, Dept Syst Med, Rome, Italy.
   [Rossi, Alessandro; Rossi, Rodolfo] Univ LAquila, Dept Biotechnol & Appl Clin Sci, Sect Psychiat, Laquila, Italy.
C3 Universita della Campania Vanvitelli; University of Genoa; Universita
   degli Studi di Bari Aldo Moro; University of Pisa; University of Rome
   Tor Vergata; University of L'Aquila
RP Luciano, M (corresponding author), Univ Campania L Vanvitelli, Dept Psychiat, Naples, Italy.
EM mario.luciano@unicampania.it
RI Rodolico, Alessandro/GQQ-5888-2022; Rossi, Rodolfo/P-9228-2019;
   Sampogna, Gaia/AHH-4608-2022; Di Lorenzo, Giorgio/B-1308-2013; Fiorillo,
   Andrea/AHH-4551-2022
OI Sampogna, Gaia/0000-0002-9547-2793; Di Lorenzo,
   Giorgio/0000-0002-0576-4064; Fiorillo, Andrea/0000-0002-6926-0762; ,
   Vincenzo/0000-0003-3294-1748; Luciano, Mario/0000-0002-4338-1371
FU Italian Ministry of Education, Universities and Research within the
   framework of the "Progetti di Rilevante Interesse Nazionale (PRIN)
   [2015C7374S]
FX This work was supported by the Italian Ministry of Education,
   Universities and Research within the framework of the "Progetti di
   Rilevante Interesse Nazionale (PRIN)-year 2015" (Grant Number:
   2015C7374S).
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NR 94
TC 14
Z9 15
U1 0
U2 16
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0924-9338
EI 1778-3585
J9 EUR PSYCHIAT
JI Eur. Psychiat.
PD NOV 23
PY 2021
VL 64
IS 1
AR e72
DI 10.1192/j.eurpsy.2021.2253
PG 9
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA XK6WY
UT WOS:000727604500001
PM 34812136
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Sacchetti, E
   Galluzzo, A
   Valsecchi, P
   Romeo, F
   Gorini, B
   Warrington, L
AF Sacchetti, Emilio
   Galluzzo, Alessandro
   Valsecchi, Paolo
   Romeo, Fabio
   Gorini, Barbara
   Warrington, Lewis
CA MOZART Study Grp
TI Ziprasidone vs clozapine in schizophrenia patients refractory to
   multiple antipsychotic treatments: The MOZART study
SO SCHIZOPHRENIA RESEARCH
LA English
DT Article
DE Ziprasidone; Clozapine; Treatment resistance; Tolerability
ID TREATMENT-RESISTANT SCHIZOPHRENIA; DRUG-NAIVE PATIENTS; DEPRESSION
   RATING-SCALE; NEGATIVE SYNDROME SCALE; DOUBLE-BLIND; METABOLIC SYNDROME;
   ATYPICAL ANTIPSYCHOTICS; GLUCOSE-TOLERANCE; DIABETES-MELLITUS; PHYSICAL
   HEALTH
AB This 18-week, randomized, flexible-dose, double-blind, double-dummy trial evaluated ziprasidone as an alternative to clozapine in treatment-refractory schizophrenia patients. Patients had a DSM-IV diagnosis of schizophrenia, a history of resistance and/or intolerance to at least three acute cycles with different antipsychotics given at therapeutic doses, PANSS score >= 80, and CGI-S score >= 4. Patients were randomized to ziprasidone (80-160 mg/day, n = 73) or clozapine (250-600 mg/day, n=74). On the primary ITT-LOCF analysis, baseline-to-endpoint decreases in PANSS total scores were similar in the ziprasidone (-25.0 +/- 22.0, 95% CI -30.2 to -19.8) and clozapine (-24.5 +/- 22.5, 95% CI -29.7 to -19.2) groups. A progressive and significant reduction from baseline in PANSS total score was observed from day 11 in both study arms. There were also significant improvements on PANSS subscales, CGI-S, CG-I, COSS, and GAF, without between-drug differences. The two treatment groups had similar rates of early discontinuations due to AEs. AEs were mostly of similar mild-moderate severity in the two groups. There were also no detrimental effects on prolactin, renal and liver function, hematology, and cardiovascular parameters. However, ziprasidone but not clozapine showed a significant reduction of SAS and AIMS scores. Moreover, when compared with clozapine, ziprasidone also had a more favorable metabolic profile, with significant endpoint differences in weight, fasting glucose, total cholesterol. LDL cholesterol, and triglycerides. In conclusion, this trial indicates that both ziprasidone and clozapine, having comparable efficacy coupled with satisfactory general safety and tolerability, may be regarded as valuable options for the short-term treatment of difficult-to-treat schizophrenia patients with a history of multiple resistance and/or intolerance to antipsychotics. The more favorable metabolic profile of ziprasidone may represent an added value that could guide clinicians, at least in the presence of patients at high risk for metabolic disorders. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Sacchetti, Emilio] Univ Brescia, Sch Med, Chair Psychiat, Brescia, Italy.
   [Sacchetti, Emilio; Galluzzo, Alessandro; Valsecchi, Paolo] Brescia Spedali Civili, Dept Mental Hlth, Brescia, Italy.
   [Sacchetti, Emilio] Univ Brescia, Univ Psychiat Unit, Sch Med, Spedali Civili, I-25133 Brescia, Italy.
   [Sacchetti, Emilio] Univ Brescia, Ctr Behav & Neurodegenerat Disorders, Brescia, Italy.
   [Sacchetti, Emilio] EULO, Brescia, Italy.
   [Romeo, Fabio; Gorini, Barbara] Pfizer Italia, Dept Med, Rome, Italy.
   [Warrington, Lewis] Pfizer Inc, New York, NY USA.
C3 University of Brescia; Hospital Spedali Civili Brescia; University of
   Brescia; University of Brescia; Pfizer; Pfizer Italy; Pfizer; Pfizer USA
RP Sacchetti, E (corresponding author), Univ Brescia, Univ Psychiat Unit, Sch Med, Spedali Civili, Ple Spedali Civili 1, I-25133 Brescia, Italy.
EM sacchett@med.unibs.it
RI Galluzzo, Alessandro/B-5257-2012
OI NIOLU, CINZIA/0000-0001-6173-2684
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NR 69
TC 35
Z9 36
U1 0
U2 12
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0920-9964
EI 1573-2509
J9 SCHIZOPHR RES
JI Schizophr. Res.
PD AUG
PY 2009
VL 113
IS 1
BP 112
EP 121
DI 10.1016/j.schres.2009.05.002
PG 10
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 481YW
UT WOS:000268850800018
PM 19606529
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Turghun, C
   Bakri, M
   Abdulla, R
   Ma, QL
   Aisa, HA
AF Turghun, Chimengul
   Bakri, Mahinur
   Abdulla, Rahima
   Ma, Qingling
   Aisa, Haji Akber
TI Comprehensive characterisation of phenolics from Nitraria
   sibirica leaf extracts by UHPLC-quadrupole-orbitrap- MS and
   evaluation of their anti-hypertensive activity
SO JOURNAL OF ETHNOPHARMACOLOGY
LA English
DT Article
DE Nitraria sibirica; UHPLC-Quadrupole-orbitrap-MS; Quantitative analysis;
   Anti-hypertension; Oxidative stress and endothelial dysfunction
ID CHEMICAL-CONSTITUENTS; METABOLIC SYNDROME; CHLOROGENIC ACID;
   BLOOD-PRESSURE; ANTIOXIDANT; HYPERTENSION; QUANTIFICATION; BLUEBERRIES;
   BIOMARKERS; ALKALOIDS
AB Ethnopharmacological relevance: For more than ten scores years, the leaves and fruits of Nitraria sibirica have been used as a natural remedy for indigestion, irregular manes, and hypertension in the Middle East and Central Asia, especially, are recommended for hypertension treatment in the northwest region, China.
   Aim of the study: we aimed to support the traditional usage of N. sibirica leaves as pharmaceuticals or dietary supplements in treatment of hypertension by investigating their chemical constituents and anti-hypertensive activity.
   Methods: We identified the chemical composition of N. sibirica leaves ethanolic purified extract (NSL-EPE) using UHPLC-quadrupole-orbitrap-MS, and quantified the main chemical constituents by an analytical method established and validated. We also evaluated anti-hypertensive activity of NSL-EPE using spontaneously hypertensive rats (SHR): blood pressure was measured weekly by non-invasive blood pressure (NIBP) measurements; hemodynamic parameters, biochemical and clinical chemistry variables in plasma, serum and kidney tissue were measured after 10 weeks of treatment with NSL-EPE as well.
   Results: UHPLC-quadrupole-orbitrap-MS analysis identified 52 compounds, of which 40 compounds were reported for the first time in N. sibirica. 11 phenolic compounds further quantitatively analyzed, among which the most abundant compound was found to be clovin (8.8%). Systolic blood pressure decreased progressively from the second treatment week compared to that in non-treated SHRs. The plasma endothelin, aldosterone, angiotensin II levels were significantly increased, while the level of NOx was significantly decreased; glutathione to oxidized glutathione ratio, superoxide dismutase and total catalase levels in the kidney tissue were markedly accelerated, while malondialdehyde level was significantly reduced in NSL-EPE treated SHRs. Moreover, the serum cholesterol, triglyceride, blood uria nitrogen and creatinine were attenuated in NSL-EPE treated SHRs (P < 0.05), but in sharp contrast to those values in the water-treated SHRs.
   Conclusion: This study screened out leading compounds from N. sibirica and offered a new understanding of the antihypertensive properties of N. sibirica leaves, by which inhibit oxidative stress-induced endothelial dysfunction and improve lipid profiles.
C1 [Turghun, Chimengul; Bakri, Mahinur; Abdulla, Rahima; Ma, Qingling; Aisa, Haji Akber] Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Plant Resources & Chem Arid Zone, Urumqi 830011, Peoples R China.
   [Turghun, Chimengul; Bakri, Mahinur; Abdulla, Rahima; Ma, Qingling; Aisa, Haji Akber] Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, State Key Lab Basis Xinjiang Indigenous Med Plant, Urumqi 830011, Peoples R China.
   [Turghun, Chimengul] Univ Chinese Acad Sci, Beijing 100049, Peoples R China.
C3 Chinese Academy of Sciences; Xinjiang Technical Institute of Physics &
   Chemistry, CAS; Chinese Academy of Sciences; Xinjiang Technical
   Institute of Physics & Chemistry, CAS; Chinese Academy of Sciences;
   University of Chinese Academy of Sciences, CAS
RP Aisa, HA (corresponding author), Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, 40-1 South Beijing Rd, Urumqi 830011, Xinjiang, Peoples R China.
EM haji@ms.xjb.ac.cn
FU China National Funds for Distinguished Young Scientists [30925045]
FX This work was supported by the China National Funds for Distinguished
   Young Scientists [grant number 30925045].
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NR 70
TC 8
Z9 9
U1 2
U2 33
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0378-8741
EI 1872-7573
J9 J ETHNOPHARMACOL
JI J. Ethnopharmacol.
PD OCT 28
PY 2020
VL 261
AR 113019
DI 10.1016/j.jep.2020.113019
PG 10
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA NJ9DF
UT WOS:000566343600001
PM 32540258
DA 2025-06-11
ER

PT J
AU Radu, G
   Bordejevic, AD
   Buda, V
   Tomescu, MC
   Dragan, I
   Dehelean, L
   Cocos, IL
   Cheveresan, A
   Andor, M
AF Radu, Gabriela
   Bordejevic, Aurora Diana
   Buda, Valentina
   Tomescu, Mirela Cleopatra
   Dragan, Ioan
   Dehelean, Liana
   Cocos, Ionut Lucian
   Cheveresan, Adelina
   Andor, Minodora
TI CARDIOVASCULAR RISK FACTORS FOR DIFFERENT TYPES OF PSYCHIATRIC
   PATHOLOGIES. A CORRELATIVE STUDY
SO FARMACIA
LA English
DT Article
DE cardiovascular diseases; psychiatric severe illnesses; cardiovascular
   risk factors
ID CORONARY-HEART-DISEASE; ENDOTHELIAL DYSFUNCTION; HYPERTENSIVE PATIENTS;
   INFLAMMATORY MARKERS; METABOLIC SYNDROME; CIGARETTE-SMOKING; BIPOLAR
   DISORDER; MENTAL-ILLNESS; PLASMA-LEVELS; SCHIZOPHRENIA
AB Cardiovascular diseases (CVD) and psychiatric severe illnesses (PSI) are the leading causes of morbidity and mortality worldwide and the link between CVD and PSI has been studied for decades. The aim of this study was to evaluate the impact of classical cardiovascular risk factors (age, sex, smoking status, alcohol, arterial hypertension, lipid profile) and Framingham Score for the 10-year risk of death from cardiovascular diseases, in different types of severe mental illnesses. On the basis of the premise that patients with psychiatric illness have a life expectancy of 10 - 17.5 years less than the general population, predominantly associated with cardiovascular disease, we conducted a retrospective study of 165 patients admitted in the psychiatric clinic for a period of 1 year. Cardiovascular risk factors as well as other risk factors for cardiovascular disease (presence of associated medication, renal function, alcohol use) were calculated for all 165 patients. The mean systolic blood pressure was 136.7 mmHg (patient group) compared with 130 mmHg (control group); total cholesterol was 244 mg/dL (patient group) compared with 187.2 mg/dL ( control group); and high-density lipoprotein (HDL) cholesterol was 36.7 mg/dL (patient group) compared with 46.4 mg/dL (control group). In addition, the Framingham score was 12.7 in the group of PSI patients compared with 5.47 in the control group. According to our results, the patients with severe mental illness were clearly all at an increased risk of cardiovascular-related death compared with the control group, odds ratio (OR) = 4.030. The highest OR was found in patients with Alzheimer's disease ( OR = 62.171), but also in patients with severe depression (OR = 4.371), and patients with schizophrenia (OR = 3.288). On the basis of these results, clinicians should screen all psychiatric patients for increased body mass index, elevated blood pressure, and cholesterol, and begin medical treatment and non-medical intervention to decrease this cardiovascular risk as soon as possible.
C1 [Radu, Gabriela; Bordejevic, Aurora Diana; Tomescu, Mirela Cleopatra; Andor, Minodora] Victor Babes Univ Med & Pharm, Dept Internal Med 1, Med Semiol 2, Timisoara, Romania.
   [Buda, Valentina] Victor Babes Univ Med & Pharm, Dept Pharmacol & Clin Pharm, Timisoara, Romania.
   [Dragan, Ioan] Victor Babes Univ Med & Pharm, Dept Med Informat & Biostat, Timisoara, Romania.
   [Dehelean, Liana] Victor Babes Univ Med & Pharm, Dept Neurosci Psychiat, Timisoara, Romania.
   [Cocos, Ionut Lucian] Teodor Andrei Hosp City, Dept Psychiat, Lugoj, Romania.
   [Cheveresan, Adelina] Victor Babes Univ Med & Pharm, Dept Pharmacol, Timisoara, Romania.
C3 Victor Babes University of Medicine & Pharmacy, Timisoara; Victor Babes
   University of Medicine & Pharmacy, Timisoara; Victor Babes University of
   Medicine & Pharmacy, Timisoara; Victor Babes University of Medicine &
   Pharmacy, Timisoara; Victor Babes University of Medicine & Pharmacy,
   Timisoara
RP Buda, V (corresponding author), Victor Babes Univ Med & Pharm, Dept Pharmacol & Clin Pharm, Timisoara, Romania.
EM buda.valentina.oana@gmail.com
RI Dehelean, Liana/P-2768-2016; Andor, Minodora/KEH-5890-2024; Tomescu,
   Mirela Cleopatra/M-9101-2014; Buda, Valentina/LWH-8867-2024; Arnautu,
   Diana Aurora/AAI-3289-2020
OI Arnautu, Diana Aurora/0000-0001-9959-5718
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NR 49
TC 4
Z9 4
U1 2
U2 11
PU SOC STIINTE FARMACEUTICE ROMANIA
PI BUCURESTI
PA BUCURESTI, STR TRAIAN VUIA 6, SECT 1, BUCURESTI, 020956, ROMANIA
SN 0014-8237
EI 2065-0019
J9 FARMACIA
JI Farmacia
PD SEP-OCT
PY 2020
VL 68
IS 5
BP 835
EP 842
DI 10.31925/farmacia.2020.5.9
PG 8
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA OI4LJ
UT WOS:000583251900009
OA gold
DA 2025-06-11
ER

PT J
AU John, OD
   Mushunje, AT
   Surugau, N
   Guad, RM
AF John, Oliver Dean
   Mushunje, Annals Tatenda
   Surugau, Noumie
   Guad, Rhanye Mac
TI The metabolic and molecular mechanisms of α-mangostin in cardiometabolic
   disorders (Review)
SO INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
LA English
DT Review
DE alpha-mangostin; Garcinia mangostana; xanthone; metabolic syndrome;
   obesity; metabolism
ID GARCINIA-MANGOSTANA; IN-VITRO; OXIDATIVE STRESS; NITRIC-OXIDE;
   PRENYLATED XANTHONES; TISSUE DISTRIBUTION; SIGNALING PATHWAYS; HEPATIC
   STEATOSIS; PERICARP EXTRACT; ADIPOSE-TISSUE
AB alpha-mangostin is a xanthone predominantly encountered in Garcinia mangostana. Extensive research has been carried out concerning the effects of this compound on various diseases, including obesity, cancer and metabolic disorders. The present review suggests that alpha-mangostin exerts promising anti-obesity, hepatoprotective, antidiabetic, cardioprotective, antioxidant and anti-inflammatory effects on various pathways in cardiometabolic diseases. The anti-obesity effects of alpha-mangostin include the reduction of body weight and adipose tissue size, the increase in fatty acid oxidation, the activation of hepatic AMP-activated protein kinase and Sirtuin-1, and the reduction of peroxisome proliferator-activated receptor gamma expression. Hepatoprotective effects have been revealed, due to reduced fibrosis through transforming growth factor-beta 1 pathways, reduced apoptosis and steatosis through reduced sterol regulatory-element binding proteins expression. The antidiabetic effects include decreased fasting blood glucose levels, improved insulin sensitivity and the increased expression of GLUT transporters in various tissues. Cardioprotection is exhibited through the restoration of cardiac functions and structure, improved mitochondrial functions, the promotion of M2 macrophage populations, reduced endothelial and cardiomyocyte apoptosis and fibrosis, and reduced acid sphingomyelinase activity and ceramide depositions. The antioxidant effects of alpha-mangostin are mainly related to the modulation of antioxidant enzymes, the reduction of oxidative stress markers, the reduction of oxidative damage through a reduction in Sirtuin 3 expression mediated by phosphoinositide 3-kinase/protein kinase B/peroxisome proliferator-activated receptor-gamma coactivator-1 alpha signaling pathways, and to the increase in Nuclear factor-erythroid factor 2-related factor 2 and heme oxygenase-1 expression levels. The anti-inflammatory effects of alpha-mangostin include its modulation of nuclear factor-kappa B related pathways, the suppression of mitogen-activated protein kinase activation, increased macrophage polarization to M2, reduced inflammasome occurrence, increased Sirtuin 1 and 3 expression, the reduced expression of inducible nitric oxide synthase, the production of nitric oxide and prostaglandin E2, the reduced expression of Toll-like receptors and reduced proinflammatory cytokine levels. These effects demonstrate that alpha-mangostin may possess the properties required for a suitable candidate compound for the management of cardiometabolic diseases.
C1 [John, Oliver Dean; Surugau, Noumie] Univ Malaysia Sabah, Fac Sci & Nat Resources, Kota Kinabalu 88400, Sabah, Malaysia.
   [John, Oliver Dean; Mushunje, Annals Tatenda] Asia Pacific Int Univ, Fac Sci, Sara Buri 18180, Thailand.
   [Guad, Rhanye Mac] Univ Malaysia Sabah, Fac Med & Hlth Sci, Kota Kinabalu 88400, Sabah, Malaysia.
   [John, Oliver Dean] Univ Malaysia Sabah, Fac Sci & Nat Resources, UMS Rd, Kota Kinabalu 88400, Sabah, Malaysia.
C3 Universiti Kebangsaan Malaysia; Universiti Malaysia Sabah; Universiti
   Malaysia Sabah; Universiti Kebangsaan Malaysia; Universiti Malaysia
   Sabah
RP John, OD (corresponding author), Univ Malaysia Sabah, Fac Sci & Nat Resources, UMS Rd, Kota Kinabalu 88400, Sabah, Malaysia.
EM oliverdjohn@ums.edu.my
RI Guad, rhanye/AAD-6332-2022; John, Oliver/AAX-5651-2021; Surugau,
   Noumie/I-4899-2016
OI John, Oliver Dean/0000-0001-5035-1878; Surugau,
   Noumie/0000-0003-1271-1486
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NR 165
TC 21
Z9 21
U1 0
U2 18
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1107-3756
EI 1791-244X
J9 INT J MOL MED
JI Int. J. Mol. Med.
PD SEP
PY 2022
VL 50
IS 3
AR 120
DI 10.3892/ijmm.2022.5176
PG 37
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 3R1GE
UT WOS:000838666700001
PM 35904170
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Mancini, A
   Leone, E
   Festa, R
   Grande, G
   Di Donna, V
   De Marinis, L
   Pontecorvi, A
   Tacchino, RM
   Littarru, GP
   Silvestrini, A
   Meucci, E
AF Mancini, Antonio
   Leone, Erika
   Festa, Roberto
   Grande, Giuseppe
   Di Donna, Vincenzo
   De Marinis, Laura
   Pontecorvi, Alfredo
   Tacchino, Roberto Maria
   Littarru, Gian Paolo
   Silvestrini, Andrea
   Meucci, Elisabetta
TI Evaluation of antioxidant systems (coenzyme Q10 and total antioxidant
   capacity) in morbid obesity before and after biliopancreatic diversion
SO METABOLISM-CLINICAL AND EXPERIMENTAL
LA English
DT Article
ID HOMEOSTASIS MODEL ASSESSMENT; INCREASED OXIDATIVE STRESS; INSULIN
   SENSITIVITY; METABOLIC SYNDROME; PLASMA; RISK; RESISTANCE; LEPTIN;
   Q(10); ATHEROSCLEROSIS
AB Biliopancreatic diversion (BPD) is a surgical procedure performed in patients with untreatable obesity and insulin resistance. The demonstrated metabolic and hormonal results of this procedure include the reversal of insulin resistance; an increase in diet-induced thermogenesis; and modifications of gut hormones, such as gastrin, enteroglucagon, neurotensin, and cholecystokinin. On the other hand, obesity is a condition of increased oxidative stress; however, few studies have investigated antioxidant systems in obese persons with BPD. To evaluate the metabolic status and antioxidant systems in such patients, we studied a group of I I morbidly obese patients, aged 28 to 62years, with a mean body mass index (BMI) of 54.71 +/- 2.52 kg/m(2), before and after successful BPD (mean post-BPD BMI, 44.68 +/- 1.51 kg/m(2)). A control group composed of 10 slightly overweight women, with a mean BMI of 28.5 +/- 0.72 kg/m(2). was also studied. Coenzyme Q(10) (CoQ(10)) levels (also normalized for cholesterol levels) and total antioxidant capacity in blood plasma were assessed in these populations. The most striking datum was the extremely low level of CoQ(10) in postoperative period (0.34 +/- 0.16 vs 0.66 +/- 0.09 mu g/mL, P = .04); also, the data corrected for cholesterol levels presented the same pattern, with a more marked significance (152.46 +/- 11.13 vs 186.4 +/- 17.98 nmol/mmol, P = .001). This could be due to lipid malabsorption after surgery. In fact, the pre-BPD data present all the metabolic and hormonal characteristics of severe obesity; and after BPD, there was a net improvement in the metabolic parameters. The first pathophysiologic phenomenon seems to be lipid malabsorption that has been argued to be the cause of insulin resistance reversion. This metabolic interpretation is also confirmed by the absence of significant variations of total antioxidant capacity (57.5 +/- 5.3 vs 66 5.3). The mechanisms of these phenomena remain to be established. These data suggest the importance of correcting postsurgical metabolic complications, in these clinical populations, with CoQ(10) supplementation. (C) 2008 Elsevier Inc. All rights reserved.
C1 [Mancini, Antonio; Leone, Erika; Festa, Roberto; Grande, Giuseppe; Di Donna, Vincenzo; De Marinis, Laura; Pontecorvi, Alfredo] Univ Cattolica Sacro Cuore, Chair Endocrinol, I-00135 Rome, Italy.
   [Tacchino, Roberto Maria] Univ Cattolica Sacro Cuore, Dept Gen Surg, I-00135 Rome, Italy.
   [Littarru, Gian Paolo] Univ Politecn Marche, Inst Biochem, I-60100 Ancona, Italy.
   [Silvestrini, Andrea; Meucci, Elisabetta] Univ Cattolica Sacro Cuore, Inst Biochem & Clin Biochem, I-00135 Rome, Italy.
C3 Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli;
   Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli;
   Marche Polytechnic University; Catholic University of the Sacred Heart;
   IRCCS Policlinico Gemelli
RP Mancini, A (corresponding author), Univ Cattolica Sacro Cuore, Chair Endocrinol, I-00135 Rome, Italy.
EM mancini.giac@mclink.it
RI Pontecorvi, Alfredo/K-5146-2016; Grande, Giuseppe/AAC-2813-2019; Di
   Donna, Vincenzo/AAC-1687-2019; Silvestrini, Andrea/B-3410-2009
OI Grande, Giuseppe/0000-0003-3264-0937; Silvestrini,
   Andrea/0000-0002-2005-3746; PONTECORVI, Alfredo/0000-0003-0570-6865; Di
   Donna, Vincenzo/0000-0002-7934-0619; MEUCCI,
   Elisabetta/0000-0002-8821-8041
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NR 52
TC 27
Z9 27
U1 0
U2 4
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0026-0495
EI 1532-8600
J9 METABOLISM
JI Metab.-Clin. Exp.
PD OCT
PY 2008
VL 57
IS 10
BP 1384
EP 1389
DI 10.1016/j.metabol.2008.05.007
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 363BI
UT WOS:000260240500012
PM 18803943
DA 2025-06-11
ER

PT J
AU Saberi-Karimian, M
   Khorasanchi, Z
   Ghazizadeh, H
   Tayefi, M
   Saffar, S
   Ferns, GA
   Ghayour-Mobarhan, M
AF Saberi-Karimian, Maryam
   Khorasanchi, Zahra
   Ghazizadeh, Hamideh
   Tayefi, Maryam
   Saffar, Sara
   Ferns, Gordon A.
   Ghayour-Mobarhan, Majid
TI Potential value and impact of data mining and machine learning in
   clinical diagnostics
SO CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES
LA English
DT Review
DE Data mining; machine learning; decision tree
ID REFERENCE INTERVALS; LOGISTIC-REGRESSION; PREDICTION MODEL;
   RISK-FACTORS; CLASSIFICATION; BIOMARKERS; MEDICINE; CARE
AB Data mining involves the use of mathematical sciences, statistics, artificial intelligence, and machine learning to determine the relationships between variables from a large sample of data. It has previously been shown that data mining can improve the prediction and diagnostic precision of type 2 diabetes mellitus. A few studies have applied machine learning to assess hypertension and metabolic syndrome-related biomarkers, as well as refine the assessment of cardiovascular disease risk. Machine learning methods have also been applied to assess new biomarkers and survival outcomes in patients with renal diseases to predict the development of chronic kidney disease, disease progression, and renal graft survival. In the latter, random forest methods were found to be the best for the prediction of chronic kidney disease. Some studies have investigated the prognosis of nonalcoholic fatty liver disease and acute liver failure, as well as therapy response prediction in patients with viral disorders, using decision tree models. Machine learning techniques, such as Sparse High-Order Interaction Model with Rejection Option, have been used for diagnosing Alzheimer's disease. Data mining techniques have also been applied to identify the risk factors for serious mental illness, such as depression and dementia, and help to diagnose and predict the quality of life of such patients. In relation to child health, some studies have determined the best algorithms for predicting obesity and malnutrition. Machine learning has determined the important risk factors for preterm birth and low birth weight. Published studies of patients with cancer and bacterial diseases are limited and should perhaps be addressed more comprehensively in future studies. Herein, we provide an in-depth review of studies in which biochemical biomarker data were analyzed using machine learning methods to assess the risk of several common diseases, in order to summarize the potential applications of data mining methods in clinical diagnosis. Data mining techniques have now been increasingly applied to clinical diagnostics, and they have the potential to support this field.
C1 [Saberi-Karimian, Maryam; Ghazizadeh, Hamideh; Saffar, Sara; Ghayour-Mobarhan, Majid] Mashhad Univ Med Sci, Int UNESCO Ctr Hlth Related Basic Sci & Human Nut, Mashhad, Razavi Khorasan, Iran.
   [Saberi-Karimian, Maryam; Ghazizadeh, Hamideh] Mashhad Univ Med Sci, Student Res Comm, Mashhad, Razavi Khorasan, Iran.
   [Khorasanchi, Zahra] Mashhad Univ Med Sci, Fac Med, Dept Nutr, Mashhad, Razavi Khorasan, Iran.
   [Tayefi, Maryam] Univ Hosp North Norway, Norwegian Ctr Hlth Res, Tromso, Norway.
   [Ferns, Gordon A.] Brighton & Sussex Med Sch, Div Med Educ, Falmer, England.
C3 Mashhad University of Medical Sciences; Mashhad University of Medical
   Sciences; Mashhad University of Medical Sciences; UiT The Arctic
   University of Tromso; University Hospital of North Norway; University of
   Brighton; University of Sussex
RP Ghayour-Mobarhan, M (corresponding author), Mashhad Univ Med Sci, Pardis Univ, Int UNESCO Ctr Hlth Related Basic Sci & Human Nut, Mashhad 9919991766, Razavi Khorasan, Iran.
EM ghayourm@mums.ac.ir
RI khorasanchi, zahra/ABD-4405-2021; Ghazizadeh, Hamideh/ABE-8941-2020;
   Soflaei, Sara/AAI-1461-2019; Ghayour-Mobarhan, Majid/AAY-5963-2020
OI Ghayour Mobarhan, Majid/0000-0002-1081-6754; khorasanchi,
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NR 113
TC 65
Z9 68
U1 8
U2 104
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1040-8363
EI 1549-781X
J9 CRIT REV CL LAB SCI
JI Crit. Rev. Clin. Lab. Sci.
PD MAY 19
PY 2021
VL 58
IS 4
BP 275
EP 296
DI 10.1080/10408363.2020.1857681
EA MAR 2021
PG 22
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA SR7IN
UT WOS:000630680000001
PM 33739235
DA 2025-06-11
ER

PT J
AU Dunican, KC
   Desilets, AR
   Montalbano, JK
AF Dunican, Kaelen C.
   Desilets, Alicia R.
   Montalbano, Julie K.
TI Pharmacotherapeutic options for overweight adolescents
SO ANNALS OF PHARMACOTHERAPY
LA English
DT Article
DE adolescents; metformin; obesity; orlistat; sibutramine
ID RANDOMIZED CONTROLLED-TRIAL; CARDIOVASCULAR RISK-FACTORS;
   PLACEBO-CONTROLLED TRIAL; CANNABINOID-1 RECEPTOR BLOCKER; LONG-TERM
   TREATMENT; WEIGHT-LOSS; OBESE ADOLESCENTS; DOUBLE-BLIND; METABOLIC
   SYNDROME; LIPASE INHIBITOR
AB OBJECTIVE: To evaluate the safety and efficacy of current pharmacotherapeutic options for weight loss in overweight adolescents.
   DATA SOURCES: Literature was obtained through MEDLINE Ovid (1996-April 2007) and EMBASE Drugs and Pharmacology (1991-2nd quarter 2007) searches and a bibliographic review of published articles. Key words included adolescents, overweight, obesity, anti-obesity agents, drug therapy, orlistat, sibutramine, and metformin.
   STUDY SELECTION AND DATA EXTRACTION: All studies published in the English language that evaluated the use of pharmacotherapy for the treatment of overweight adolescents were critically analyzed; pertinent articles were selected for this review.
   DATA SYNTHESIS: Orlistat has been approved for use in adolescents between the ages of 12 and 16 years. The most frequently reported adverse effects of orlistat were gastrointestinal; reduced concentrations of fat-soluble vitamins were also observed. Of the 6 clinical trials published, 5 have shown statistically significant reductions in body mass index (BMI) from baseline, ranging from 0.55 to 4.09 kg/m(2); one small trial failed to demonstrate significant weight reduction compared with placebo. Sibutramine has also been evaluated for use in overweight adolescents in 6 trials. Trials demonstrated a statistically significant reduction in BMI up to 5.6 kg/m(2) (from, baseline). Of concern is evidence indicating that sibutramine therapy may be associated with elevated blood pressure, increased pulse rate, depression, and suicidal ideations. Lastly, metformin has recently been evaluated for weight loss in overweight adolescents; small, short-term trials demonstrate modest reductions in weight and BMI.
   CONCLUSIONS: Orlistat has been proven both safe and effective for weight reduction in overweight adolescents. Sibutramine has also been proven effective in reducing weight in this population; however, the potential for severe adverse effects requires further investigation. Metformin has demonstrated promising results in small trials; its role in the treatment of overweight adolescents will remain investigational until further research is conducted.
C1 Massachusetts Coll Pharm & Hlth Sci, Worcester, MA USA.
RP Dunican, KC (corresponding author), 19 Foster St, Worcester, MA 01608 USA.
EM Kaelen.Dunican@mcphs.edu
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   2005, PRODUCT INFORM
   2006, PRODUCT INFORM
NR 66
TC 25
Z9 26
U1 0
U2 1
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1060-0280
EI 1542-6270
J9 ANN PHARMACOTHER
JI Ann. Pharmacother.
PD SEP
PY 2007
VL 41
IS 9
BP 1445
EP 1455
DI 10.1345/aph.1K022
PG 11
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 203DT
UT WOS:000248956000012
PM 17652127
DA 2025-06-11
ER

PT J
AU Zhou, MS
   Schulman, IH
   Raij, L
AF Zhou, Ming-Sheng
   Schulman, Ivonne Hernandez
   Raij, Leopoldo
TI Role of angiotensin II and oxidative stress in vascular insulin
   resistance linked to hypertension
SO AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
LA English
DT Article
DE endothelial function; salt sensitivity
ID KAPPA-B PATHWAY; ENDOTHELIAL FUNCTION; METABOLIC SYNDROME; RECEPTOR
   BLOCKERS; NITRIC-OXIDE; GLUCOSE-METABOLISM; SALT SENSITIVITY;
   BLOOD-PRESSURE; SYSTEM; PHOSPHORYLATION
AB Zhou MS, Schulman IH, Raij L. Role of angiotensin II and oxidative stress in vascular insulin resistance linked to hypertension. Am J Physiol Heart Circ Physiol 296: H833-H839, 2009. First published January 16, 2009; doi:10.1152/ajpheart.01096.2008.-Insulin activation of the phosphatidylinositol 3-kinase (PI3K) pathway stimulates glucose uptake in peripheral tissues and synthesis of nitric oxide (NO) in the endothelium. Insulin resistance (IR) and hypertension frequently coexist, particularly among individuals with salt-sensitive hypertension. The mechanisms underlying this association are poorly understood. We investigated these mechanisms in a model of salt-sensitive hypertension in which we have previously shown that endothelial dysfunction is mediated by superoxide anion (O-2(-)) linked to local ANG II. Dahl salt-sensitive rats were fed, for 6 wk, a normal salt diet (NS; 0.5% NaCl), high-salt diet (HS; 4% NaCl), HS plus the ANG II type 1 receptor (AT(1)R) blocker (ARB) candesartan (10 mg.kg(-1).day(-1)), or HS plus the antioxidant tempol (172 mg/l in drinking water). Hypertensive (mean arterial pressure: 145 +/- 4 vs. 102 +/- 5 mmHg in NS, P < 0.05) rats manifested increased aortic AT1R mRNA (210%) and protein (101%) expression and O-2(-) production (104%) and impaired endothelium-dependent relaxation (EDR) to acetylcholine [maximal response (Emax): 68 +/- 9 vs. 91 +/- 8% in NS, P < 0.05]. ARB or tempol normalized O-2(-) and EDR despite that they did not normalize mean arterial pressure, which was reduced only 25%. Hypertensive rats manifested metabolic IR (36% reduction in the glucose infusion rate by insulin clamp), impaired NO-mediated insulin-induced EDR (Emax: 12 +/- 5 vs. 32 +/- 4% in NS, P < 0.05), and impaired insulin activation of PI3K/endothelial NO synthase. ARB or tempol improved insulin-mediated EDR, PI3K, Akt/ endothelial NO synthase phosphorylation, and metabolic IR (all P < 0.05). This study provides insight into the mechanisms that underlie the association between metabolic and hypertensive cardiovascular diseases and support the notion that O-2(-) overproduction linked to tissue ANG II interferes with shared insulin signaling pathways in metabolic and cardiovascular tissues.
C1 [Zhou, Ming-Sheng] Univ Miami, Nephrol Hypertens Sect, Vet Affairs Med Ctr, Miami, FL 33125 USA.
   Univ Miami, Div Nephrol & Hypertens, Miami, FL 33125 USA.
   [Zhou, Ming-Sheng] Univ Miami, Vasc Biol Inst, Miller Sch Med, Miami, FL 33125 USA.
C3 University of Miami; US Department of Veterans Affairs; Veterans Health
   Administration (VHA); University of Miami; University of Miami
RP Zhou, MS (corresponding author), Univ Miami, Nephrol Hypertens Sect, Vet Affairs Med Ctr, 1201 NW 16th St,Rm A-1009, Miami, FL 33125 USA.
EM mzhou2@med.miami.edu
RI Schulman, Ivonne/K-6436-2019
OI Schulman, Ivonne/0000-0002-2814-2321
FU University of Miami Stanley Glaser Research Foundation; American Heart
   Association National Scientist Development Award; South Florida Veterans
   Affairs Foundation for Research and Education
FX This work was supported by a University of Miami Stanley Glaser Research
   Foundation Grant and American Heart Association National Scientist
   Development Award (to M.-S. Zhou) and by funds from the South Florida
   Veterans Affairs Foundation for Research and Education ( to L. Raij).
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NR 46
TC 54
Z9 64
U1 0
U2 4
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0363-6135
EI 1522-1539
J9 AM J PHYSIOL-HEART C
JI Am. J. Physiol.-Heart Circul. Physiol.
PD MAR
PY 2009
VL 296
IS 3
BP H833
EP H839
DI 10.1152/ajpheart.01096.2008
PG 7
WC Cardiac & Cardiovascular Systems; Physiology; Peripheral Vascular
   Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Physiology
GA 412SY
UT WOS:000263745700033
PM 19151253
DA 2025-06-11
ER

PT J
AU Brasier, AR
AF Brasier, Allan R.
TI The NF-κB regulatory network
SO CARDIOVASCULAR TOXICOLOGY
LA English
DT Review
DE NF-kappa B/Rel A; I kappa B kinase (IKK); nuclear factor-kappa B
   essential modulator (NEMO); IKK gamma; canonical pathway; noncanonical
   pathway; NF-kappa B-inducing-kinase (NIK); gene networks
ID TUMOR-NECROSIS-FACTOR; DEPENDENT GENE-EXPRESSION; INDUCIBLE BCL-3
   EXPRESSION; SEVERE LIVER DEGENERATION; FACTOR-ALPHA; IKK-ALPHA;
   TRANSCRIPTION FACTOR; KINASE-ALPHA; MICE LACKING; SIGNAL-TRANSDUCTION
AB Nuclear factor (NF)-kappa B is a family of seven structurally related transcription factors that play a central role in cardiovascular growth, stress response, and inflammation by controlling gene network expression. Although the NF kappa B subunits are ubiquitously expressed, their actions are regulated in a cell-type and stimulus-specific manner, allowing for a diverse spectrum of effects. For example, NF-kappa B is activated by cytokines, reactive oxygen species, bacterial cell wall products, vasopressors, viral infection, and DNA damage. Recent molecular dissection of its mechanisms for activation has shown that NF-kappa B can be induced by the so-called "canonical" and "noncanonical" pathways, leading to distinct patterns in the individual subunits activated and downstream genetic responses produced. The canonical pathway involves activating the I kappa B kinase (IKK) with subsequent phosphorylation-induced proteolysis of the I kappa B alpha inhibitors and consequent nuclear translocation of the Rel A transcriptional activator. Recent work using high-density oligonucleotide arrays have begun to systematically dissect the scope of the gene network under canonical NF-kappa B control and have yielded important insights into biological pathways controlled by it. This pathway controls expression of noncontiguous, functionally discrete groups of genes (" regulons"), whose temporal expression occurs in waves. Moreover, its mode of activation (oscillatory or monophasic) plays an important role in determining the spectrum of target genes expressed. By contrast, the noncanonical NF-kappa B activation pathway involves activating the NF-kappa B inducing kinase (NIK) to stimulate IKK alpha-induced phosphorylation and proteolytic processing of the 100-kDa cytoplasmic NF-kappa B2 precursor. Activated NF-kappa B2 then forms a complex with Rel B and NIK to translocate into the nucleus thereby activating a distinct set of genes. Although the noncanonical pathway has been most clearly linked to control of adaptive immunity, recent intriguing studies have implicated this pathway in viral induced stress response and in the metabolic syndrome. In this way, a single family of transcription factors can respond to diverse stimuli to regulate cardiovascular homeostasis.
C1 [Brasier, Allan R.] Univ Texas Galveston, Med Branch, Dept Internal Med, Galveston, TX 77555 USA.
   [Brasier, Allan R.] Univ Texas Galveston, Med Branch, Sealy Ctr Mol Sci, Galveston, TX 77555 USA.
C3 University of Texas System; University of Texas Medical Branch
   Galveston; University of Texas System; University of Texas Medical
   Branch Galveston
RP Brasier, AR (corresponding author), Univ Texas Galveston, Med Branch, Div Endocrinol, Sealy Ctr Mol Med, MRB 8-138, Galveston, TX 77555 USA.
EM arbrasie@utmb.edu
RI Brasier, allan/LSI-6520-2024
OI Brasier, Allan/0000-0002-5012-4090
FU NIAID NIH HHS [P01 AI062885, AI40218] Funding Source: Medline; NIEHS NIH
   HHS [P30 ES06676] Funding Source: Medline; FDA HHS [BA-HL-02-04] Funding
   Source: Medline
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NR 116
TC 471
Z9 581
U1 0
U2 35
PU HUMANA PRESS INC
PI TOTOWA
PA 999 RIVERVIEW DRIVE SUITE 208, TOTOWA, NJ 07512 USA
SN 1530-7905
EI 1559-0259
J9 CARDIOVASC TOXICOL
JI Cardiovasc. Toxicol.
PD JUN
PY 2006
VL 6
IS 2
BP 111
EP 130
DI 10.1385/CT:6:2:111
PG 20
WC Cardiac & Cardiovascular Systems; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Toxicology
GA V44NR
UT WOS:000203009900004
PM 17303919
DA 2025-06-11
ER

PT J
AU Gong, HY
   Duan, SQ
   Huang, SQ
AF Gong, Hongyang
   Duan, Shuqin
   Huang, Shaoqun
TI Association between Life's Crucial 9 and overactive bladder: the
   mediating role of weight-adjusted-waist index
SO FRONTIERS IN NUTRITION
LA English
DT Article
DE Life's Crucial 9; overactive bladder; weight-adjusted-waist index;
   NHANES; mediation analysis
ID URINARY-TRACT SYMPTOMS; METABOLIC SYNDROME; VISCERAL FAT; OBESITY; OAB;
   EPIDEMIOLOGY; DEPRESSION; HEALTH; WOMEN; RISK
AB Background: Research suggests a potential connection between cardiovascular health, obesity, and overactive bladder (OAB). However, the mechanisms by which obesity influences the relationship between cardiovascular health and OAB remain unclear. Life's Crucial 9 (LC9) is a recently proposed method for assessing cardiovascular health, while the weight-adjusted waist index (WWI) is a novel and more accurate measure of obesity. This study investigates the relationship between LC9 and OAB and assesses whether WWI moderates this relationship. Methods: Data for this study came from the National Health and Nutrition Examination Survey (NHANES). We used subgroup analyses, restricted cubic spline curves (RCS), and multivariate logistic regression to explore the relationship between LC9 and OAB. Additionally, mediation analysis was conducted to investigate the potential association between WWI levels and the relationship between LC9 and OAB. Results: A total of 25,319 participants were included in this study, among which 5,038 reported incidents of OAB. After adjusting for all variables using multivariable logistic regression, an increase of 10 units in LC9 was associated with a 28% reduction in the incidence of OAB (OR = 0.72, 95% CI: 0.69, 0.76), while an increase of one unit in WWI was associated with a 40% increase in the incidence of OAB (OR = 1.40, 95% CI: 1.29, 1.51). Consistent results were also observed when LC9 and WWI were categorized into quartiles, with a P for trend <0.001. The analysis using restricted cubic splines indicated a linear negative correlation between the incidence of OAB and LC9. Mediation analysis revealed that 13.89% of the relationship between LC9 and OAB was mediated by WWI (p = 0.002). Conclusion: This study found a significant negative correlation between LC9 and OAB, with WWI acting as a partial mediator in this relationship. This study provides new insights for future research into the relationship between LC9 and OAB and the role of WWI as a mediator.
C1 [Gong, Hongyang; Huang, Shaoqun] Fujian Univ Tradit Chinese Med, Dept Oncol Surg, Fuzhou Hosp Tradit Chinese Med Affiliated, Fuzhou, Fujian, Peoples R China.
   [Gong, Hongyang] Chosun Univ, Coll Med, Dept Physiol, Gwangju, South Korea.
   [Duan, Shuqin] Second Hosp Jilin Univ, Dept Obstet & Gynaecol, Changchun, Jilin, Peoples R China.
C3 Fujian University of Traditional Chinese Medicine; Chosun University;
   Jilin University
RP Huang, SQ (corresponding author), Fujian Univ Tradit Chinese Med, Dept Oncol Surg, Fuzhou Hosp Tradit Chinese Med Affiliated, Fuzhou, Fujian, Peoples R China.
EM sqhuang@fjtcm.edu.cn
RI huang, shaoqun/LIG-2455-2024; Gong, Hongyang/LIG-2366-2024
FX The author(s) declare that no financial support was received for the
   research, authorship, and/or publication of this article.
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NR 51
TC 3
Z9 3
U1 1
U2 1
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD JAN 6
PY 2025
VL 11
AR 1508062
DI 10.3389/fnut.2024.1508062
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA S7W5B
UT WOS:001400278300001
PM 39834451
OA gold
DA 2025-06-11
ER

PT J
AU Farhang, S
   Shirzadi, M
   Alikhani, R
   Alizadeh, BZ
   Bruggeman, R
   Veling, W
AF Farhang, Sara
   Shirzadi, Maryam
   Alikhani, Rosa
   Alizadeh, Behrooz Z.
   Bruggeman, Richard
   Veling, Wim
CA Aras investigators
TI ARAS recent onset acute phase psychosis survey, a prospective
   observational cohort of first episode psychosis in Iran-the cohort
   profile
SO SCHIZOPHRENIA
LA English
DT Article
ID QUALITY-OF-LIFE; 1ST-EPISODE PSYCHOSIS; PSYCHOMETRIC PROPERTIES;
   UNTREATED PSYCHOSIS; MENTAL-ILLNESS; SCHIZOPHRENIA; RELIABILITY;
   DISORDERS; PEOPLE; DURATION
AB The Middle East is underrepresented in psychosis research. The ARAS recent onset acute phase psychosis survey (ARAS) is a longitudinal cohort across multiple centers in Iran, established to investigate characteristics, determinants and early course of psychosis in a non-Western, Middle East context. Here, baseline characteristics of the ARAS cohort are reported. The ARAS cohort enrolled patients with recent onset psychosis from September 2018 to September 2021 in East Azerbaijan, Kermanshah and Tehran, including Iranian patients from different sociocultural contexts. The baseline assessment included demographics, socioeconomic status, clinical (positive, negative, depressive symptoms) and psychosocial (religiosity, social support, self-stigma) characteristics, cognitive functioning, metabolic profile, substance use and medication use measured by validated questionnaires. These assessments will be followed up after one and five years. A total of 500 patients with a first episode of psychosis were enrolled from three provinces in Iran. With 74.1% being male, the mean age (SD) of patients was 32.3 (9.7) years. Nearly a quarter of patients was diagnosed with schizophrenia and 36.8% with substance induced psychotic disorder. Amphetamine (24%) and opium (12%) use were common, cannabis use was not (5%). Only 6.1% of patients lived alone while 29% of patients was married and had children. The majority of them had achieved secondary educational level and 34% had a paid job. The most common antipsychotic treatment was risperidone. There was a wide range for scores of PANSS, with 9.4% having dominant negative symptoms. The most common prescribed medication was risperidone. Near to 40% of patients had noticeable signs of depression and prevalence of metabolic syndrome was 13.4%. The majority of patients (57.2%) had moderate and 5.4% reported to have severe disability. More than 30% reported to be highly religious. Patients had the highest satisfaction with people living with, and the lowest for finance and job.
C1 [Farhang, Sara; Bruggeman, Richard] Univ Groningen, Univ Ctr Psychiat, Univ Med Ctr Groningen, Rob Giel Res Ctr, Groningen, Netherlands.
   [Farhang, Sara] Tabriz Univ Med Sci, Res Ctr Psychiat & Behav Sci, Tabriz, Iran.
   [Shirzadi, Maryam] Kermanshah Univ Med Sci, Imam Reza Hosp, Clin Res Dev Ctr, Kermanshah, Iran.
   [Alikhani, Rosa] Univ Social Welf & Rehabil, Psychosis Res Ctr, Dept Psychiat, Tehran, Iran.
   [Alizadeh, Behrooz Z.] Univ Groningen, Univ Med Ctr Groningen, Dept Epidmiol, Groningen, Netherlands.
   [Veling, Wim] Univ Groningen, Univ Med Ctr Groningen, Dept Psychiat, Groningen, Netherlands.
C3 University of Groningen; Tabriz University of Medical Science;
   Kermanshah University of Medical Sciences; University of Groningen;
   University of Groningen
RP Farhang, S (corresponding author), Univ Groningen, Univ Ctr Psychiat, Univ Med Ctr Groningen, Rob Giel Res Ctr, Groningen, Netherlands.; Farhang, S (corresponding author), Tabriz Univ Med Sci, Res Ctr Psychiat & Behav Sci, Tabriz, Iran.
EM s.farhang@umcg.nl
RI alikhani, rosa/M-6070-2017; van Os, Jim/V-8884-2019; Farhang,
   Sara/A-9883-2009; Alizadeh, Behrooz/J-2921-2017; Naghdi Sadeh,
   Reza/I-1231-2018
OI Naghdi Sadeh, Reza/0000-0002-3541-812X; Mohagheghi,
   Arash/0000-0003-0550-3101; Veling, Wim/0000-0002-1364-9779
FU National Institute for Medical Research Development (NIMAD), Iran
FX Authors would like to thank clinical research development units of Razi
   hospital. This study was funded by the National Institute for Medical
   Research Development (NIMAD), Iran.
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NR 43
TC 1
Z9 1
U1 0
U2 2
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
EI 2754-6993
J9 SCHIZOPHRENIA-UK
JI Schizophr.
PD NOV 19
PY 2022
VL 8
IS 1
AR 101
DI 10.1038/s41537-022-00295-z
PG 9
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychiatry
GA 6N4MX
UT WOS:000889533100001
PM 36402780
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Heringa, SM
   van den Berg, E
   Reijmer, YD
   Nijpels, G
   Stehouwer, CDA
   Schalkwijk, CG
   Teerlink, T
   Scheffer, PG
   van den Hurk, K
   Kappelle, LJ
   Dekker, JM
   Biessels, GJ
AF Heringa, S. M.
   van den Berg, E.
   Reijmer, Y. D.
   Nijpels, G.
   Stehouwer, C. D. A.
   Schalkwijk, C. G.
   Teerlink, T.
   Scheffer, P. G.
   van den Hurk, K.
   Kappelle, L. J.
   Dekker, J. M.
   Biessels, G. J.
TI Markers of low-grade inflammation and endothelial dysfunction are
   related to reduced information processing speed and executive
   functioning in an older population - the Hoorn Study
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE Low-grade inflammation; Endothelial dysfunction; Cognitive functioning;
   Vascular risk factors; Cardiovascular disease
ID C-REACTIVE PROTEIN; COGNITIVE DECLINE; GENERAL-POPULATION; METABOLIC
   SYNDROME; VASCULAR DEMENTIA; DIABETES-MELLITUS; ASSOCIATION; DISEASE;
   HEMOSTASIS; DEPRESSION
AB Low-grade inflammation and endothelial dysfunction are related to cognitive decline and dementia, in a complex interplay with vascular factors and aging. We investigated, in an older population, low-grade inflammation and endothelial dysfunction in relation to detailed assessment of cognitive functioning. Furthermore, we explored this association within the context of vascular factors.
   377 participants (73 +/- 6 years) of the population-based Hoorn Study were included. In plasma samples of 2000-2001 (n = 363) and/or 2005-2008 (n = 323), biomarkers were determined of low-grade inflammation (CRP, TNF-alpha, IL-6, IL-8, SAA, MPO, and sICAM-1) and endothelial dysfunction (vWF, sICAM-1, sVCAM-1, sTM, sE-selectin). In 2005-2008, all participants underwent neuropsychological examination. Composite z-scores were computed for low-grade inflammation and endothelial dysfunction at both time points, and for six domains of cognitive functioning (abstract reasoning, memory, information processing speed, attention and executive functioning, visuoconstruction, and language). The association between low-grade inflammation and endothelial dysfunction, and cognitive functioning was evaluated with linear regression analysis. In secondary analyses, we explored the relation with vascular risk factors and cardiovascular disease.
   Low-grade inflammation and endothelial dysfunction were associated with worse performance on information processing speed and attention and executive functioning, in prospective and cross-sectional analyses (standardized betas ranging from -0.20 to -0.10). No significant relation with other cognitive domains was observed. Adjusting for vascular factors slightly attenuated the associations. Low-grade inflammation and endothelial dysfunction accounted for only 2.6% explained variance in cognitive functioning, on top of related vascular risk factors and cardiovascular disease. Bootstrapping analyses show that low-grade inflammation and endothelial dysfunction mediate the relation between vascular risk factors and cognitive functioning.
   This study shows that low-grade inflammation and endothelial dysfunction contribute to reduced information processing speed and executive functioning in an older population. (C) 2013 Elsevier Ltd. All rights reserved.
C1 [Heringa, S. M.; van den Berg, E.; Kappelle, L. J.; Biessels, G. J.] Univ Med Ctr Utrecht, Brain Ctr Rudolf Magnus, Dept Neurol, NL-3508 GA Utrecht, Netherlands.
   [van den Berg, E.] Univ Utrecht, Helmholtz Inst, Dept Expt Psychol, Utrecht, Netherlands.
   [Reijmer, Y. D.] Massachusetts Gen Hosp, J Philip Kistler Stroke Res Ctr, Boston, MA 02114 USA.
   [Nijpels, G.; Dekker, J. M.] Vrije Univ Amsterdam, Med Ctr, Inst Res Extramural Med, EMGO Inst, Amsterdam, Netherlands.
   [Nijpels, G.] Vrije Univ Amsterdam, Med Ctr, Dept Gen Practice, Amsterdam, Netherlands.
   [Stehouwer, C. D. A.; Schalkwijk, C. G.] Maastricht Univ, Med Ctr, Dept Internal Med, Maastricht, Netherlands.
   [Stehouwer, C. D. A.; Schalkwijk, C. G.] Maastricht Univ, Med Ctr, Cardiovasc Res Inst Maastricht CARIM, Maastricht, Netherlands.
   [Teerlink, T.; Scheffer, P. G.] Vrije Univ Amsterdam, Med Ctr, Dept Clin Chem, Amsterdam, Netherlands.
   [van den Hurk, K.] Sanquin Blood Supply, Dept Donor Studies, Amsterdam, Netherlands.
C3 Utrecht University; Utrecht University Medical Center; Utrecht
   University; Harvard University; Harvard University Medical Affiliates;
   Massachusetts General Hospital; Vrije Universiteit Amsterdam; Vrije
   Universiteit Amsterdam; Maastricht University; Maastricht University;
   Vrije Universiteit Amsterdam
RP Heringa, SM (corresponding author), Univ Med Ctr Utrecht, Dept Neurol, G03-232,POB 85500, NL-3508 GA Utrecht, Netherlands.
EM s.m.heringa@umcutrecht.nl
RI Emmer, Bart/AAA-2817-2021; van den Berg, Esther/ABD-8026-2020; van den
   Hurk, Katja/JOK-6159-2023; Stehouwer, Coen/AAB-3435-2021
OI van den Berg, Esther/0000-0002-8120-7366; van den Hurk,
   Katja/0000-0003-3241-6003; Nijpels, Giel/0000-0002-3679-9710; Stehouwer,
   Coen/0000-0001-8752-3223; Schalkwijk, Casper G/0000-0003-0190-2690
FU Dutch Diabetes Research Foundation [2003.01.004]; Netherlands Heart
   Foundation [2010T073]; Internationale Stichting Alzheimer Onderzoek
   (ISAO) [10506]
FX The research of GJB is supported by grant 2003.01.004 of the Dutch
   Diabetes Research Foundation and grant 2010T073 from the Netherlands
   Heart Foundation. SMH is supported by a Internationale Stichting
   Alzheimer Onderzoek (ISAO) grant 10506. The authors have no relevant
   conflict of interest.
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NR 53
TC 89
Z9 99
U1 0
U2 9
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD FEB
PY 2014
VL 40
BP 108
EP 118
DI 10.1016/j.psyneuen.2013.11.011
PG 11
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA AB6TB
UT WOS:000331921300013
PM 24485482
DA 2025-06-11
ER

PT J
AU Hu, YT
   Kong, YZ
   Tian, XL
   Zhang, XY
   Zuo, Y
AF Hu, Yitao
   Kong, Yuzhe
   Tian, Xinling
   Zhang, Xinyi
   Zuo, Yu
TI Association between Heavy metals and triglyceride-glucose-related index:
   a mediation analysis of inflammation indicators
SO LIPIDS IN HEALTH AND DISEASE
LA English
DT Article
DE Heavy metal; Inflammation; Triglyceride; Glucose Index; Glucose Index
   and Waist Circumference; Glucose Index and Waist Height Ratio; Glucose
   Index and Body Mass Index; Mediation analysis; National Health and
   Nutrition Examination Survey
ID METABOLIC SYNDROME; QUALITY-CONTROL; MARKERS; BETA
AB BackgroundIn cardiovascular diseases (CVD) and insulin resistance (IR), elevated blood lipids and glucose are common. These abnormalities accelerate atherosclerosis and may impair insulin signaling via oxidative stress and inflammation. The triglyceride-glucose (TyG) index is a cost-effective marker for assessing IR and CVD risk, reflecting insulin resistance and early atherosclerosis. However, research on factors affecting the TyG index, especially mixed heavy metal exposure, is limited. Heavy metals might alter the TyG index by inducing oxidative stress and inflammation, affecting lipid and glucose metabolism. This study explores the link between heavy metal exposure and TyG index changes, focusing on inflammation's mediating role, aiming to offer new strategies for CVD and IR prevention and management.MethodThis research explores the association between heavy metal concentrations and TyG indicators, drawing on data from the National Health and Nutrition Examination Survey spanning 2011 to 2016. It employs a range of statistical approaches, such as linear and non-linear analyses, multiple linear regression, weighted quantile sum regression, and Bayesian kernel machine regression. Additionally, a mediation analysis investigates the role of inflammation in modifying the effects of heavy metal exposure.ResultThe research analyzed data from a sample of 2,050 individuals, finding notable links between mixed heavy metals and variations in TyG markers. Specifically, the presence of heavy metal mixtures was associated with significant increases in these indicators. Additionally, six inflammatory markers were identified that act as intermediaries in the process leading from heavy metal exposure to alterations in TyG indicators.ConclusionThe study establishes a clear association between heavy metal and adverse changes in TyG markers, influenced in part by inflammation. These insights highlight the urgent need for improved monitoring of environmental health and specific strategies to decrease heavy metal exposure, thus lessening their harmful impact on cardiovascular health. The research enhances understanding of the dynamic interactions between environmental exposures and metabolic health, laying groundwork for public health initiatives aimed at curtailing chronic disease risks linked to heavy metals.
C1 [Hu, Yitao; Kong, Yuzhe; Tian, Xinling] Cent South Univ, Xiangya Sch Med, Changsha, Peoples R China.
   [Zhang, Xinyi] Wenzhou Univ, Coll Educ, Wenzhou, Peoples R China.
   [Zuo, Yu] Cent South Univ, Xiangya Hosp 3, Changsha, Peoples R China.
C3 Central South University; Wenzhou University; Central South University
RP Zuo, Y (corresponding author), Cent South Univ, Xiangya Hosp 3, Changsha, Peoples R China.
EM 86761568@qq.com
RI Zhang, Xinyi/KFS-1704-2024; Kong, Yuzhe/LNR-4769-2024
OI Kong, Yu-zhe/0009-0000-6540-9921
FU School of Computer Science and Engineering, Central South University
FX We thank Lei Wang and Xiaoyan Kui from the School of Computer Science
   and Engineering, Central South University for providing guidance on the
   organization of the clinical data. We thank Shuping Yang from School of
   Mathematics and Statistics, Central South University, and Yang Zhou,
   Guifang Yang from the Second Xiangya Hospital of Central South
   University for providing guidance on data analysis and statistics. We
   thank Yun Xie, Haiying Shi, and Yuan Tang from the School of Foreign
   Languages, Central South University for providing guidance on the
   language of the manuscript. We thank all the researchers and people who
   participated in the construction of the NHANES database.
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NR 54
TC 3
Z9 3
U1 4
U2 4
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1476-511X
J9 LIPIDS HEALTH DIS
JI Lipids Health Dis.
PD FEB 13
PY 2025
VL 24
IS 1
AR 46
DI 10.1186/s12944-025-02441-9
PG 15
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA W7I7K
UT WOS:001420271000002
PM 39948676
OA gold
DA 2025-06-11
ER

PT J
AU Gandhi, GR
   Hillary, VE
   Antony, PJ
   Zhong, LLD
   Yogesh, D
   Krishnakumar, NM
   Ceasar, SA
   Gan, RY
AF Gandhi, Gopalsamy Rajiv
   Hillary, Varghese Edwin
   Antony, Poovathumkal James
   Zhong, Linda L. D.
   Yogesh, Devarajan
   Krishnakumar, Neenthamadathil Mohandas
   Ceasar, Stanislaus Antony
   Gan, Ren-You
TI A systematic review on anti-diabetic plant essential oil compounds:
   Dietary sources, effects, molecular mechanisms, and safety
SO CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
LA English
DT Review
DE Essential oil; insulin resistance; interleukins; dietary plants; type 2
   diabetes mellitus
ID INDUCED INSULIN-RESISTANCE; ACTIVATED PROTEIN-KINASE; HEPATIC KEY
   ENZYMES; OXIDATIVE STRESS; CARBOHYDRATE-METABOLISM; COGNITIVE
   DYSFUNCTION; CHEMICAL-COMPOSITION; GLUCOSE-METABOLISM; LIPID-METABOLISM;
   SKELETAL-MUSCLE
AB Type 2 diabetes mellitus (T2DM) is a multifaceted metabolic syndrome defined through the dysfunction of pancreatic beta-cells driven by a confluence of genetic and environmental elements. Insulin resistance, mediated by interleukins and other inflammatory elements, is one of the key factors contributing to the progression of T2DM. Many essential oils derived from dietary plants are beneficial against various chronic diseases. We reviewed the anti-diabetic properties of dietary plant-derived essential oil compounds, with a focus on their molecular mechanisms by modulating specific signaling pathways and other critical inflammatory mediators involved in insulin resistance. High-quality literature published in the last 12years, from 2010 to 2022, was collected from the Scopus, Web of Science, PubMed, and Embase databases using the search terms "dietary plants, " "essential oils, " "anti-diabetic, " "insulin resistance, " "antihyperglycemic, " "T2DM, " "anti-diabetic essential oils, " and anti-diabetic mechanism. " According to the results, the essential oil compounds, including cinnamaldehyde, carvacrol, zingerone, sclareol, zerumbone, myrtenol, thujone, geraniol, citral, eugenol, thymoquinone, thymol, citronellol, a-terpineol, and linalool have been demonstrated to contain strong anti-diabetic effects via modulating various signal transduction pathways linked to glucose metabolism. Additionally, in diabetes-related animal models, they can also considerably reduce the expression of TNF-a, IL-1 beta, IL-4, IL-6, iNOS, and COX-2. The main signaling molecules regulated by these compounds include AMPK, GLUT4, Caspase-3, PPAR gamma, PPARa, NF-KB, p-IKBa, MyD88, MCP-1, SREBP-1c, AGEs, RAGE, VEGF, Nrf2/HO-1, and SIRT-1. They can also significantly inhibit the generation of TBARS and MDA, reduce oxidative stress, increase insulin levels, adiponectin, and glycoprotein enzymes, boost antioxidant enzymes like SOD, CAT, and GPx, as well as reduce glutathione and vital glycolytic enzymes. Besides, they can significantly lower the levels of liver enzymes and lipid profile markers. Moreover, most essential oil compounds are generally safe based on animal studies. In conclusion, dietary plant-derived essential oil compounds have potential anti-diabetic effects by influencing different signaling pathways and molecular targets linked to glucose metabolism, and should be safe and beneficial against diabetes and related complications.{GRAPHICAL ABTSRACT}
C1 [Gandhi, Gopalsamy Rajiv; Hillary, Varghese Edwin; Krishnakumar, Neenthamadathil Mohandas] Rajagiri Coll Social Sci Autonomous, Dept Biosci, Div Phytochem & Drug Design, Kochi, India.
   [Antony, Poovathumkal James] Nepal Jesuit Soc, Human Resource Dev & Res Ctr, Kathmandu, Nepal.
   [Zhong, Linda L. D.] Nanyang Technol Univ, Sch Biol Sci, Biomed Sci & Chinese Med, Singapore, Singapore.
   [Yogesh, Devarajan] Univ Madras, Dept Biochem, Chennai, India.
   [Ceasar, Stanislaus Antony] Rajagiri Coll Social Sci, Dept Biosci, Div Plant Mol Biol & Biotechnol, Kochi, India.
   [Gan, Ren-You] ASTAR, Singapore Inst Food & Biotechnol Innovat SIFBI, Singapore, Singapore.
C3 Rajagiri College of Social Sciences; Nanyang Technological University;
   University of Madras; Rajagiri College of Social Sciences; Agency for
   Science Technology & Research (A*STAR); A*STAR - Singapore Institute of
   Food & Biotechnology Innovation (SIFBI)
RP Antony, PJ (corresponding author), Nepal Jesuit Soc, Human Resource Dev & Res Ctr, Kathmandu, Nepal.; Gan, RY (corresponding author), ASTAR, Singapore Inst Food & Biotechnol Innovat SIFBI, Singapore, Singapore.
EM jamesantonysj@gmail.com; ganry@sifbi.a-star.edu.sg
RI Zhong, Linda/HJA-9771-2022; Hillary, Edwin/AGZ-4998-2022; Gopalsamy,
   Rajiv/GLR-2711-2022; Gan, Renyou/C-9868-2009; N. M.,
   Krishnakumar/HGE-8752-2022; Stanislaus, Antony Ceasar/P-2479-2017
OI Stanislaus, Antony Ceasar/0000-0003-4106-1531; Zhong,
   Linda/0000-0002-3877-1914
FU Rajagiri College of Social Sciences
FX The authors thank Rajagiri College of Social Sciences (Autonomous),
   Kalamaserry, Kochi, for providing total research assistance. Rajagiri
   College of Social Sciences (Autonomous) offered financial support for
   this project in the category of seed money for faculty Minor Research
   Projects (MRP).
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NR 144
TC 26
Z9 26
U1 1
U2 48
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1040-8398
EI 1549-7852
J9 CRIT REV FOOD SCI
JI Crit. Rev. Food Sci. Nutr.
PD JUL 25
PY 2024
VL 64
IS 19
BP 6526
EP 6545
DI 10.1080/10408398.2023.2170320
EA JAN 2023
PG 20
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA XE2V4
UT WOS:000920671700001
PM 36708221
DA 2025-06-11
ER

PT J
AU Potz, BA
   Sabe, AA
   Elmadhun, NY
   Feng, J
   Liu, YH
   Mitchell, H
   Quesenberry, P
   Abid, MR
   Sellke, FW
AF Potz, Brittany A.
   Sabe, Ashraf A.
   Elmadhun, Nassrene Y.
   Feng, Jun
   Liu, Yuhong
   Mitchell, Hunter
   Quesenberry, Peter
   Abid, M. Ruhul
   Sellke, Frank W.
TI Calpain inhibition decreases myocardial apoptosis in a swine model of
   chronic myocardial ischemia
SO SURGERY
LA English
DT Article
ID ENDOTHELIAL DYSFUNCTION; CORONARY-ARTERY; HYPERCHOLESTEROLEMIA;
   INTRACORONARY; RESVERATROL; PERFUSION; DISEASE
AB Introduction. Calpain is a family of cysteine proteases that has an important role in the initiation, regulation, and execution of cell death. Our recent studies using a hypercholesterolemic swine model demonstrated that in the setting of the metabolic syndrome, calpain inhibition (CI) improved collateral-dependent perfusion and increased expression of proteins implicated in angiogenesis and vasodilation. In this study, we hypothesized that CI (by MLD28170) would decrease myocardial apoptosis in the same model.
   Methods. Yorkshire swine, all fed a high-cholesterol diet for 4 weeks underwent placement of an ameroid constrictor on the left circumflex coronary artery. Three weeks later, animals received either no drug, termed the high-cholesterol control group (HCC; n = 8); low-dose CI (0.12 mg/kg; LCI, n = 9); or high-dose CI (0.25 mg/kg; HCI, n = 8). The high-cholesterol diet and the CI were continued for 5 weeks, after which the pig was humanely killed and the left ventricular myocardium was harvested and analyzed via terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) staining, oxyblot analysis, and Western blots. Data were analyzed using the Kruskal Wallis test.
   Results. The percentage of apoptotic cells to total cells in ischemic myocardial territory was decreased in the LCI and HCI groups compared with the HCC group as shown by TUNEL staining (P = .018). There was a decrease in proapoptotic proteins, including cleaved caspase 3, caspase 9, cleaved caspase 9, Bax, BAD, p-BAD, and Erk 1/2 (P <= .049 each), but no decrease in caspase 3 (P = .737). There was also an increase in antiapoptotic proteins, including BCL-2 and p-BCL2 (P <= .025 each). In the ischemic myocardium, several proangiogenic proteins were increased in the LCI and HCI groups compared with the HCC group, including p-AKT, p-eNOS, and eNOS (P <= .006 each) but there was no increase in AKT (P = .311). CI decreased tissue oxidative stress in both the LCI and HCI groups compared to the HCC group as shown by oxyblot analysis (P = .021).
   Conclusion. In the setting of hypercholesterolemia, CI decreases apoptosis and the expression of proteins in proapoptotic signaling pathways. CI also increased expression of proteins implicated in anti apoptotic pathways and improves oxidative stress in ischemic myocardial tissue.
C1 [Potz, Brittany A.; Sabe, Ashraf A.; Elmadhun, Nassrene Y.; Feng, Jun; Liu, Yuhong; Mitchell, Hunter; Quesenberry, Peter; Abid, M. Ruhul; Sellke, Frank W.] Brown Univ, Rhode Isl Hosp, Dept Surg, Div Cardiothorac Surg,Alpert Med Sch,Cardiovasc R, Providence, RI 02903 USA.
C3 Lifespan Health Rhode Island; Rhode Island Hospital; Brown University
RP Sellke, FW (corresponding author), Div Cardiothorac Surg, 2 Dudley St,MOC 360, Providence, RI 02905 USA.
EM fsellke@lifespan.org
OI Feng, Jun/0000-0003-4762-7532
FU National Institute of Health [HL-46716]; NIGMS/NIH [1P20GM103652 01A1];
   American Heart Association [14GRNT20460291]; Rhode Island Foundation
   [RIF-20123834, NIH-5P20 GM1P20GM103652]; NIH Training grant
   [5T32-HL094300-03]; National Heart, Lung and Blood Institute, National
   Institutes of Health [5R25HL088992-06]; American Heart Association (AHA)
   [14GRNT20460291] Funding Source: American Heart Association (AHA)
FX This research project was supported in part by the National Institute of
   Health R01 grants-HL-46716 (F.W.S); NIGMS/NIH grant 1P20GM103652 01A1
   (Project# 3) and American Heart Association Grant-in-Aid 14GRNT20460291
   (M.R.A.); Rhode Island Foundation-RIF-20123834 and NIH-5P20
   GM1P20GM103652 (J.F.), NIH Training grant 5T32-HL094300-03 (Drs N.Y.E.
   and A.F.S.). National Heart, Lung and Blood Institute, National
   Institutes of Health- 5R25HL088992-06 (H.M.).
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NR 21
TC 21
Z9 22
U1 0
U2 23
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0039-6060
J9 SURGERY
JI Surgery
PD AUG
PY 2015
VL 158
IS 2
BP 445
EP 452
DI 10.1016/j.surg.2015.03.034
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA CN0MU
UT WOS:000358108500018
PM 25991048
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Campbell, MS
   An, OY
   Krishnakumar, IM
   Charnigo, RJ
   Westgate, PM
   Fleenor, BS
AF Campbell, Marilyn S.
   An, Ouyang
   Krishnakumar, I. M.
   Charnigo, Richard J.
   Westgate, Philip M.
   Fleenor, Bradley S.
TI Influence of enhanced bioavailable curcumin on obesity-associated
   cardiovascular disease risk factors and arterial function: A
   double-blinded, randomized, controlled trial
SO NUTRITION
LA English
DT Article
DE Turmeric; adiposity; vascular function; vasodilation; arteriosclerosis;
   intervention
ID HIGH-DENSITY-LIPOPROTEIN; PLASMA HOMOCYSTEINE CONCENTRATIONS;
   ENDOTHELIAL FUNCTION; METABOLIC SYNDROME; OXIDATIVE STRESS;
   HEART-DISEASE; TONOMETRY; INFLAMMATION; CHOLESTEROL; MORTALITY
AB Objectives: This study aimed to determine whether an enhanced bioavailable curcumin formulation, CurQfen (R), would improve circulating cardiovascular disease related blood biomarkers and arterial function in young (age 18-35 y), obese (body mass index >= 30.0 kg/m(2)) men.
   Methods: This double-blinded, placebo-controlled trial evaluated 22 men. The participants were matched based on body mass index and randomized to the intervention (curcumin formulated with fenugreek soluble fiber, for enhanced absorption) or control (fenugreek soluble fiber) group for 12 wk at 500 mg/d without dietary modification or exercise. Blood samples and endothelial function measures were acquired at 0 and 12 wk, and blood samples were analyzed for cardiovascular disease related blood biomarkers. Furthermore, central (aortic) blood pressure and augmentation index were monitored at 0, 4, 8, and 12 wk.
   Results: After 12 wk of intervention, homocysteine levels were lower (curcumin before: 12.22 2.29 p.g/mL, after: 8.62 +/- 1.02 mu g/mL versus placebo before: 9.45 +/- 0.84 mu g/mL, after: 11.84 +/- 1.63 mu g/mL; P= 0.04) and high-density lipoprotein levels were higher (curcumin before: 40.77 +/- 5.37 mg/dL, after: 54.56 +/- 11.72 mg/dL versus placebo before: 61.20 +/- 5.76 mg/dL, after: 48.82 +/- 5.49 mg/dL; P= 0.04) in the curcumin group relative to the placebo group. However, there was no significant difference in changes between the circulating concentrations of glucose, insulin, leptin, adiponectin, or oxidative stress biomarkers in the curcumin group compared with the placebo group (P > 0.05). No changes were found with endothelial function, augmentation index, or central blood pressure in the curcumin group compared with the placebo group (P > 0.05).
   Conclusions: Our data provide evidence for an enhanced bioavailable curcumin to improve homocysteine and high-density lipoprotein concentrations, which may promote favorable cardiovascular health in young, obese men. Improvements in endothelial function or blood pressure were not observed with curcumin supplementation, thus further investigation is warranted. (C) 2019 Elsevier Inc. All rights reserved.
C1 [Campbell, Marilyn S.; An, Ouyang] Univ Kentucky, Dept Kinesiol & Hlth Promot, Lexington, KY 40506 USA.
   [Krishnakumar, I. M.] Akay Flavours & Aromat Pvt Ltd, R&D Ctr, Malayidamthuruthu PO, Cochin 683561, Kerala, India.
   [Charnigo, Richard J.; Westgate, Philip M.] Univ Kentucky, Dept Biostat, Lexington, KY 40536 USA.
   [Fleenor, Bradley S.] Ball State Univ, Human Performance Lab, Muncie, IN 47306 USA.
C3 University of Kentucky; University of Kentucky; Ball State University
RP Fleenor, BS (corresponding author), Ball State Univ, Human Performance Lab, Muncie, IN 47306 USA.
EM Bsfleenor@bsu.edu
OI Campbell, Marilyn/0000-0002-9313-0028; Illathu Madhavamenon,
   Krishnakumar/0000-0003-0594-7650
FU Akay Flavours & Aromatics Pvt. Ltd.; Arvle and Ellen Turner Thacker
   Research Fund; National Center for Advancing Translational Sciences,
   National Institutes of Health [UL1 TR000117]
FX This study was funded by Akay Flavours & Aromatics Pvt. Ltd. and the
   Arvle and Ellen Turner Thacker Research Fund and supported by the
   National Center for Advancing Translational Sciences, National
   Institutes of Health (grant number UL1 TR000117). Akay Flavours &
   Aromatics Pvt. Ltd. provided CurQfen (R) and the placebo supplements.
   The content is solely the responsibility of the authors and does not
   necessarily represent the official views of the National Institutes of
   Health.
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NR 42
TC 48
Z9 49
U1 0
U2 9
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0899-9007
EI 1873-1244
J9 NUTRITION
JI Nutrition
PD JUN
PY 2019
VL 62
BP 135
EP 139
DI 10.1016/j.nut.2019.01.002
PG 5
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA HW6TY
UT WOS:000466824700020
PM 30889454
DA 2025-06-11
ER

PT J
AU Raj, P
   Louis, XL
   Yu, LP
   Siow, YL
   Suh, MY
   Aukema, HM
   Netticadan, T
AF Raj, Pema
   Louis, Xavier L.
   Yu, Liping
   Siow, Yaw L.
   Suh, Miyoung
   Aukema, Harold M.
   Netticadan, Thomas
TI Saskatoon berry supplementation prevents cardiac remodeling without
   improving renal disease in an animal model of reno-cardiac syndrome
SO JOURNAL OF FOOD BIOCHEMISTRY
LA English
DT Article
DE Antioxidants; Reno-cardiac syndrome; Saskatoon berry
ID POLYCYSTIC KIDNEY-DISEASE; AMELANCHIER-ALNIFOLIA-NUTT.; LEFT-VENTRICULAR
   HYPERTROPHY; DIETARY SOY PROTEIN; ANGIOTENSIN-ALDOSTERONE SYSTEM;
   INDUCED METABOLIC SYNDROME; CY RAT MODEL; OXIDATIVE STRESS; ANTIOXIDANT
   ACTIVITY; ANTHOCYANINS
AB Saskatoon berry (SKB) may have the potential to counter reno-cardiac syndrome owing to its antioxidant capacity. Here, we investigated the renal and cardiovascular effects of SKB-enriched diet in a rat model of reno-cardiac disease. Two groups of wild-type rats (+/+) and two groups of Hannover Sprague-Dawley (Han:SPRD-Cy/+) rats were given either regular diet or SKB diet (10% w/w total diet) for 8 weeks. Body weight, kidney weight, kidney water content, and left ventricle (LV) weight were measured. Blood pressure (BP) was measured by the tail-cuff method. Echocardiography was performed to assess cardiac structure and function. Serum creatinine and malondialdehyde (MDA) were also measured. Han:SPRD-Cy/+ rats had significantly higher kidney weight, kidney water content, LV weight, BP, and creatinine compared with wild-type rats (+/+). The SKB diet supplementation did not reduce kidney weight, kidney water content, BP, and LV weight in Han:SPRD-Cy/+ rats. The SKB diet also resulted in higher systolic BP in Han:SPRD-Cy/+rats. Han:SPRD-Cy/+rats showed cardiac structural remodeling (higher LV wall thickness) without any cardiac functional abnormalities. Han:SPRD-Cy/+ rats also had significantly higher creatinine whereas the concentration of MDA was not different. The SKB diet supplementation reduced cardiac remodeling and the concentration of MDA without altering the concentration of creatinine in Han:SPRD-Cy/+ rats. In conclusion, Han:SPRD-Cy/+ rats developed significant renal disease, high BP, and cardiac remodeling by 8 weeks without cardiac functional impairment. The SKB diet may be useful in preventing cardiac remodeling and oxidative stress in Han:SPRD-Cy/+rats. Practical applications Saskatoon berry (SKB) is widely consumed as fresh fruit or processed fruit items and has significant commercial value. It may offer health benefits due to the presence of bioactives such as anthocyanins. SKB has very good culinary flavors, and it is an economically viable fruit crop in many parts of the world. The disease-modifying benefits of SKB are mainly ascribed to the antioxidant nature of its bioactive content. Polycystic kidney disease is a serious condition that can lead to renal and cardiac abnormalities. Here, we showed that SKB supplementation was able to mitigate cardiac remodeling and lower the level of a marker of oxidative stress in an animal model of reno-cardiac syndrome. Our study suggests that SKB possesses beneficial cardioprotective properties. Further evidence from human studies may help in increasing the consumption of SKB as a functional food.
C1 [Raj, Pema; Yu, Liping; Siow, Yaw L.; Suh, Miyoung; Aukema, Harold M.; Netticadan, Thomas] Canadian Ctr Agrifood Res Hlth & Med, Winnipeg, MB, Canada.
   [Raj, Pema; Siow, Yaw L.; Netticadan, Thomas] Univ Manitoba, Dept Physiol & Pathophysiol, Winnipeg, MB, Canada.
   [Raj, Pema; Yu, Liping; Siow, Yaw L.; Netticadan, Thomas] Agr & Agri Food Canada, Winnipeg, MB, Canada.
   [Louis, Xavier L.; Suh, Miyoung; Aukema, Harold M.] Univ Manitoba, Dept Food & Human Nutr Sci, Winnipeg, MB, Canada.
   [Louis, Xavier L.; Suh, Miyoung; Aukema, Harold M.] Richardson Ctr Funct Food & Nutraceut, Winnipeg, MB, Canada.
C3 University of Manitoba; Agriculture & Agri Food Canada; University of
   Manitoba
RP Aukema, HM; Netticadan, T (corresponding author), Canadian Ctr Agrifood Res Hlth & Med, Winnipeg, MB, Canada.
EM aukema@umanitoba.ca; tnetticadan@sbrc.ca
RI Siow, Yaw/AGE-1903-2022
OI Siow, Yaw/0000-0001-6623-2881; Aukema, Harold/0000-0002-6982-7239;
   netticadan, thomas/0000-0002-6403-8142
FU Manitoba Agriculture, Food and Rural Initiatives
FX Manitoba Agriculture, Food and Rural Initiatives.
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NR 68
TC 0
Z9 0
U1 2
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0145-8884
EI 1745-4514
J9 J FOOD BIOCHEM
JI J. Food Biochem.
PD OCT
PY 2021
VL 45
IS 10
AR e13893
DI 10.1111/jfbc.13893
EA AUG 2021
PG 11
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA WB9UC
UT WOS:000690829000001
PM 34459008
OA gold
DA 2025-06-11
ER

PT J
AU Jaimes, R
   Rocco, AG
AF Jaimes, Rafael, III
   Rocco, Angelo G.
TI Multiple epidural steroid injections and body mass index linked with
   occurrence of epidural lipomatosis: a case series
SO BMC ANESTHESIOLOGY
LA English
DT Article
DE Epidural lipomatosis; Epidural steroid injection; Obesity; Cortisol;
   Sciatica
ID PITUITARY-ADRENAL AXIS; METABOLIC SYNDROME; CUSHINGS-SYNDROME;
   WEIGHT-REDUCTION; OBESE PATIENTS; COMPRESSION; ALCOHOL; STRESS; DIET;
   FAT
AB Background: Epidural lipomatosis (EL) is an increase of adipose tissue, normally occurring in the epidural space, sufficient to distort the thecal sac and compress neural elements. There is a lack of knowledge of risk factors, impact on patient's symptoms, and its possible association with epidural steroid injections.
   Methods: History, physical examination, patient chart, and MRI were analyzed from 856 outpatients referred for epidural steroid injections. Seventy patients with signs of EL on MRI comprised the study group. Thirty-four randomly selected patients comprised the control group. The severity of EL was determined by the MRI assessment. The impact of EL was determined by the patient's history and physical examination. Logistic regression was used to correlate the probability of developing EL with BMI and epidural steroid injections.
   Results: EL was centered at L5 and S1 segments. The average BMI for patients with EL was significantly greater than that of control group (36.0 +/- 0.9 vs. 29.2 +/- 0.9, p < 0.01). The probability of developing EL with increasing BMI was linear up to the BMI of 35 after which it plateaued. Triglycerides were significantly higher for the EL group as compared to controls (250 +/- 30 vs. 186 +/- 21 mg/dL p < 0.01). The odds of having EL were 60% after two epidural steroid injections, 90% after three epidural steroid injections and approached 100% with further injections, independent of BMI. Other risk factors considered included alcohol abuse, use of protease inhibitors, levels of stress, hypothyroidism and genetic predisposition. However there were insufficient quantities to determine statistical significance with a degree of confidence. The impact of EL on patient's symptoms correlated with EL severity with Spearman correlation coefficient of 0.73 at p < 0.01 significance level.
   Conclusions: The BMI and triglycerides levels were found to be significantly elevated for the EL group, pointing to an increased risk of EL occurrence in progressively more obese US population. The data also revealed a strong correlation between the number of subsequent epidural steroid injections and EL occurrence calling for caution with the use of corticosteroids.
C1 [Jaimes, Rafael, III] George Washington Univ, Washington, DC 20037 USA.
   [Rocco, Angelo G.] Harvard Vanguard Med Assoc, Dept Orthoped, Boston, MA 02215 USA.
C3 George Washington University; Harvard Vanguard Medical Associates
RP Jaimes, R (corresponding author), George Washington Univ, 2300 1st NW Ross Hall Room 456, Washington, DC 20037 USA.
EM rafjaimes@gmail.com
OI Jaimes, Rafael/0000-0002-5493-0399
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NR 43
TC 22
Z9 22
U1 0
U2 3
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-2253
J9 BMC ANESTHESIOL
JI BMC Anesthesiol.
PD AUG 15
PY 2014
VL 14
AR 70
DI 10.1186/1471-2253-14-70
PG 9
WC Anesthesiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Anesthesiology
GA AN9EH
UT WOS:000340908300002
PM 25183952
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Arcan, C
   Hou, W
   Hoffman, K
   Reichardt, A
   Yang, XH
   Clouston, SAP
   Bromet, EJ
   Luft, B
AF Arcan, Chrisa
   Hou, Wei
   Hoffman, Kathryn
   Reichardt, Amanda
   Yang, Xiaohua
   Clouston, Sean A. P.
   Bromet, Evelyn J.
   Luft, Benjamin
TI Mediterranean diet intervention among World Trade Center responders with
   post-traumatic stress disorder: Feasibility and outcomes of a pilot
   randomized controlled trial
SO OBESITY SCIENCE & PRACTICE
LA English
DT Article
DE body mass index; Mediterranean diet; post traumatic stress disorder;
   systemic inflammation; waist circumference; WTC responders
ID METABOLIC SYNDROME; PTSD; OBESITY; HEALTH; RISK; HABITS; FIREFIGHTERS;
   ASSOCIATIONS; INFLAMMATION; PREVALENCE
AB Objective: Responders of the World Trade Center (WTC) disaster suffer from co-morbidities. A Mediterranean Diet (MedDiet) nutrition intervention with physical activity was implemented among WTC responders with overweight/obesity and post-traumatic stress disorder (PTSD).Methods: WTC Health Program members (N = 62), 45-65 years, males 87%, body mass index (BMI) 27-45 kg/m2 randomized to MedDiet (n = 31) or usual nutrition counseling (n = 31). The 10-week intervention included online nutrition education, text messages, and group experiential cooking; both groups had three in-person individual nutrition counseling. Anthropometrics, serum biomarkers, psychosocial factors, MedDiet score, and PTSD symptoms were assessed at baseline, post-intervention, and 3-months (follow-up). The primary outcome was intervention feasibility and secondary outcomes were within- and between-group changes of all measures at post-intervention and follow-up. Nonparametric Wilcoxon rank sum tests for between-group comparisons and Wilcoxon signed rank tests for pre-post within-group comparisons.Results: A total of 58(94%) and 46(74%) participants completed the post-intervention and follow-up measurements, respectively. Both groups experienced significant improvements in anthropometrics, MedDiet score, oxidized low-density lipoprotein, and PTSD symptoms. Baseline median (range) were weight 100.42 (73.66-135.17) kg, BMI 33.20 (27.50-41.75) kg/m2, and Waist circumference (WC) 109.22 (90.17-150.62) cm. Median % weight loss at post-intervention was MedDiet: -3% (-11%-7%), p = 0.0002; Control: -1% (-13%-4%), p = 0.008 and at follow-up MedDiet: -2% (-14%-12%), p = 0.07; Control: -2% (-20%-3%), p = 0.006. The overall BMI was reduced by -0.68 kg/m2 (-4.61-2.09) kg/m2 p < 0.0001 at post-intervention and by -0.60 kg/m2 (-6.91-3.39) kg/m2, p < 0.0009 at follow-up. Overall, median WC was reduced (p < 0.0001); post-intervention -3.81 cm (-33.00-3.30)cm and follow-up -4.45(-38.10-4.57)cm. There were group differences in HbA1c (p = 0.019) and serum omega 6/omega 3 (p = 0.029) at post-intervention.Conclusion: Online intervention with personal counseling was feasible in this population. Improvements in anthropometrics, MedDiet score, selected serum biomarkers and PTSD symptoms were found in both groups; group differences in HbA1c and serum omega 6/omega 3. A larger study with a delayed control is needed to better assess intervention effects.
C1 [Arcan, Chrisa] Virginia Commonwealth Univ, Sch Populat Hlth, Dept Epidemiol, Capitol Sq Bldg 830 E Main St,8th Floor, Richmond, VA 23219 USA.
   [Arcan, Chrisa; Hou, Wei; Clouston, Sean A. P.] SUNY Stony Brook, Dept Family Populat & Prevent Med, Renaissance Sch Med, Stony Brook, NY USA.
   [Hou, Wei] Vertex Pharmaceut Inc, Boston, MA USA.
   [Hoffman, Kathryn; Reichardt, Amanda; Yang, Xiaohua; Luft, Benjamin] SUNY Stony Brook, Stony Brook World Trade Ctr, Hlth Plan & Wellness Program, Renaissance Sch Med, Commack, NY USA.
   [Bromet, Evelyn J.] SUNY Stony Brook, Neurosci Inst, Renaissance Sch Med, Stony Brook, NY USA.
C3 Virginia Commonwealth University; State University of New York (SUNY)
   System; Stony Brook University; Stony Brook University Hospital; Vertex
   Pharmaceuticals; State University of New York (SUNY) System; Stony Brook
   University; Stony Brook University Hospital; State University of New
   York (SUNY) System; Stony Brook University; Stony Brook University
   Hospital
RP Arcan, C (corresponding author), Virginia Commonwealth Univ, Sch Populat Hlth, Dept Epidemiol, Capitol Sq Bldg 830 E Main St,8th Floor, Richmond, VA 23219 USA.
EM arcanh@vcu.edu
RI Andrade, Laura Helena/F-3023-2010; Clouston, Sean/L-4653-2013
OI Arcan, Chrisa/0000-0003-4122-779X; Clouston, Sean/0000-0002-6124-0329
FU National Institute for Occupational Safety and Health; CDC/NIOSH
   [U01OH012057]
FX The authors would like to thank all the study participants. They would
   also like to acknowledge the help of the Clinic employees who assisted
   with participant recruitment, blood collection and other measurements,
   information technology services, and study coordination. Data for this
   study are available upon request. CDC/NIOSH U01OH012057 (Principal
   Investigator: Chrisa Arcan) National Institute for Occupational Safety
   and Health.
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NR 67
TC 2
Z9 2
U1 2
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2055-2238
J9 OBES SCI PRACT
JI OBES. SCI. PRACT.
PD FEB
PY 2024
VL 10
IS 1
DI 10.1002/osp4.725
EA DEC 2023
PG 14
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA KZ9G2
UT WOS:001128839700001
PM 38263989
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Durak, A
   Turan, B
AF Durak, Aysegul
   Turan, Belma
TI Liraglutide provides cardioprotection through the recovery of
   mitochondrial dysfunction and oxidative stress in aging hearts
SO JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
LA English
DT Article
DE Mitochondria; Intracellular Na+; glucose-co-transporter; Aging heart
ID INSULIN-RESISTANCE; GLP-1 RECEPTOR; METABOLIC-SYNDROME; SGLT2 INHIBITOR;
   HOMEOSTASIS; AGONIST; GLUCOSE; ANALOG; OUTCOMES; MODEL
AB Glucagon-like peptide-1 receptor (GLP-1R) agonists improve cardiovascular dysfunction via the pleiotropic effects behind their receptor action. However, it is unknown whether they have a cardioprotective action in the hearts of the elderly. Therefore, we examined the effects of GLP-1R agonist liraglutide treatment (LG, 4 weeks) on the systemic parameters of aged rats (24-month-old) compared to those of adult rats (6-month-old) such as electrocardiograms (ECGs) and systolic and diastolic blood pressure (SBP and DBP). At the cellular level, the action potential (AP) parameters, ionic currents, and Ca2+ regulation were examined in freshly isolated ventricular cardiomyocytes. The LG treatment of aged rats significantly ameliorated the prolongation of QRS duration and increased both SBP and DBP together with recovery in plasma oxidant and antioxidant statuses. The prolonged AP durations and depolarized membrane potentials of the isolated cardiomyocytes from the aged rats were normalized via recoveries in K+ channel currents with LG treatment. The alterations in Ca2+ regulation including leaky-ryanodine receptors (RyR2) could be also ameliorated via recoveries in Na+/Ca2+ exchanger currents with this treatment. A direct LG treatment of isolated aged rat cardiomyocytes could recover the depolarized mitochondrial membrane potential, the increase in both reactive oxygen and nitrogen species (ROS and RNS), and the cytosolic Na+ level, although the Na+ channel currents were not affected by aging. Interestingly, LG treatment of aged rat cardiomyocytes provided a significant inhibition of activated sodium-glucose co-transporter-2 (SGLT2) and recoveries in the depressed insulin receptor substrate 1 (IRS1) and increased protein kinase G (PKG). The recovery in the ratio of phospho-endothelial nitric oxide (pNOS3) level to NOS3 protein level in LG-treated cardiomyocytes implies the involvement of LG-associated inhibition of oxidative stress-induced injury via IRS1-eNOS-PKG pathway in the aging heart. Overall, our data, for the first time, provide important information on the direct cardioprotective effects of GLP-1R agonism with LG in the hearts of aged rats through an examination of recoveries in mitochondrial dysfunction, and both levels of ROS and RNS in left ventricular cardiomyocytes.
C1 [Durak, Aysegul] Ankara Univ Fac Med, Dept Biophys, Ankara, Turkey.
   [Turan, Belma] Lokman Hekim Univ Fac Med, Dept Biophys, Ankara, Turkey.
C3 Ankara University
RP Turan, B (corresponding author), Lokman Hekim Univ Fac Med, Dept Biophys, Ankara, Turkey.
EM belma.turan@medicine.ankara.edu.tr
RI TURAN, Belma/AAG-8084-2020; durak, aysegul/AAA-7647-2022
OI TURAN, Belma/0000-0003-2583-9294
FU Scientific and Technological Research Council of Turkey;  [SBAG119S661]
FX This work was supported by Grants to B.T. (No. SBAG119S661) from The
   Scientific and Technological Research Council of Turkey
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NR 36
TC 16
Z9 17
U1 0
U2 6
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1138-7548
EI 1877-8755
J9 J PHYSIOL BIOCHEM
JI J. Physiol. Biochem.
PD MAY
PY 2023
VL 79
IS 2
BP 297
EP 311
DI 10.1007/s13105-022-00939-9
EA DEC 2022
PG 15
WC Biochemistry & Molecular Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Physiology
GA K7QO2
UT WOS:000901501900001
PM 36515811
DA 2025-06-11
ER

PT J
AU Cassidy, A
   Rogers, G
   Peterson, JJ
   Dwyer, JT
   Lin, HH
   Jacques, PF
AF Cassidy, Aedin
   Rogers, Gail
   Peterson, Julia J.
   Dwyer, Johanna T.
   Lin, Honghuang
   Jacques, Paul F.
TI Higher dietary anthocyanin and flavonol intakes are associated with
   anti-inflammatory effects in a population of US adults
SO AMERICAN JOURNAL OF CLINICAL NUTRITION
LA English
DT Article
DE anthocyanins; dietary intake; flavonoids; flavonols inflammation
ID METABOLIC SYNDROME; PROTOCATECHUIC ACID; LIPID-PEROXIDATION; RISK;
   INFLAMMATION; WOMEN; BIOMARKERS; INHIBIT; CANCER; MICE
AB Background: Although growing evidence from trials and population-based studies has supported a protective role for flavonoids in relation to risk of certain chronic diseases, the underlying mechanisms remain unclear. Several previous studies focused on individual inflammatory biomarkers, but because of the limited specificity of any individual marker, an assessment of a combination of biomarkers may be more informative.
   Objective: We used an inflammation score (IS) that integrated 12 individual inflammatory biomarkers for the examination of associations with intakes of different flavonoid classes.
   Design: The study was a cross-sectional analysis of 2375 Framingham Heart Study Offspring Cohort participants. Intakes of total flavonoids and their classes (anthocyanins, flavonols, flavanones, flavan-3-ols, polymers, and flavones) were calculated from validated food-frequency questionnaires. Individual inflammatory biomarkers were ranked, standardized, and summed to derive an overall IS and subgroup scores of functionally related biomarkers.
   Results: In multivariate analyses, an inverse association between higher anthocyanin and flavonol intakes and IS was observed with a mean SE difference between quintile categories 5 and 1 of -1.48 +/- 0.32 (P-trend <= 0.001) and -0.72 +/- 0.33 (P-trend = 0.01), respectively. Results remained significant after additional adjustment for physical activity and vitamin C and fruit and vegetable intakes. Higher anthocyanin intake was inversely associated with all biomarker subgroups, whereas higher flavonol intake was associated only with lower cytokine and oxidative stress biomarker concentrations. In food-based analyses, higher intakes of apples and pears, red wine, and strawberries were associated with a lower IS with differences between quintiles 5 and 1 of -1.02 +/- 0.43 (P = 0.006), -1.73 +/- 0.39 (P < 0.001), and -0.44 +/- 0.88 (P = 0.02), respectively. Although intakes of other classes were not associated with a reduction in overall IS, higher intakes of flavan-3-ols and their polymers were associated with a significant reduction in oxidative stress biomarkers.
   Conclusion: These findings provide evidence to suggest that an anti-inflammatory effect may be a key component underlying the reduction in risk of certain chronic diseases associated with higher intakes of anthocyanins and flavonols.
C1 [Cassidy, Aedin] Univ E Anglia, Norwich Med Sch, Dept Nutr, Norwich NR4 7TJ, Norfolk, England.
   [Rogers, Gail; Dwyer, Johanna T.] Tufts Univ, Jean Mayer USDA Human Nutr Res Ctr Aging, Boston, MA 02111 USA.
   [Peterson, Julia J.; Dwyer, Johanna T.; Jacques, Paul F.] Tufts Univ, Friedman Sch Nutr Sci & Policy, Boston, MA 02111 USA.
   [Dwyer, Johanna T.] Tufts Univ, Sch Med, Boston, MA 02111 USA.
   [Dwyer, Johanna T.] Tufts Med Ctr, Frances Stern Nutr Ctr, Boston, MA USA.
   [Lin, Honghuang] Boston Univ, Sch Med, Dept Med, Sect Computat Biomed, Boston, MA 02118 USA.
C3 University of East Anglia; Tufts University; United States Department of
   Agriculture (USDA); Tufts University; Tufts University; Tufts Medical
   Center; Boston University
RP Jacques, PF (corresponding author), Tufts Univ, Jean Mayer USDA Human Nutr Res Ctr Aging, Boston, MA 02111 USA.
EM paul.jacques@tufts.edu
RI Dwyer, Johanna/AAI-5027-2020; Lin, Honghuang/A-3269-2019
OI Lin, Honghuang/0000-0003-3043-3942; Jacques, Paul/0000-0001-5567-3147;
   Dwyer, Johanna/0000-0002-0783-1769
FU International Life Sciences Institute North America; National Heart,
   Lung, and Blood Institute [N01-HC-25195, R01 HL064753, R01 HL076784, R21
   HL87217]; National Institute for Aging [R01 AG028321]; Biotechnology and
   Biological Sciences Research Council, United Kingdom [BB/J004545/1];
   USDA Agricultural Research Service [58-1950-0-014]; Royal Society
FX Supported by grants from the International Life Sciences Institute North
   America; the National Heart, Lung, and Blood Institute (contracts
   N01-HC-25195, R01 HL064753, R01 HL076784, and R21 HL87217); the National
   Institute for Aging (R01 AG028321); the Biotechnology and Biological
   Sciences Research Council, United Kingdom (reference BB/J004545/1); and
   the USDA Agricultural Research Service (agreement 58-1950-0-014). AC is
   a Royal Society Wolfson Research Merit Award Holder. This is a free
   access article, distributed under terms
   (http://www.nutrition.org/publications/guidelines-and-policies/license/)
   that permit unrestricted non-commercial use, distribution, and
   reproduction in any medium, provided the original work is properly
   cited.
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NR 47
TC 143
Z9 166
U1 2
U2 53
PU AMER SOC NUTRITION-ASN
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0002-9165
EI 1938-3207
J9 AM J CLIN NUTR
JI Am. J. Clin. Nutr.
PD JUL
PY 2015
VL 102
IS 1
BP 172
EP 181
DI 10.3945/ajcn.115.108555
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA CM1FD
UT WOS:000357425500024
PM 26016863
OA Green Published, Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Naqvi, AA
   Hassali, MA
   Aftab, MT
AF Naqvi, Atta Abbas
   Hassali, Mohamed Azmi
   Aftab, Mohammad Tariq
TI Epidemiology of rheumatoid arthritis, clinical aspects and
   socio-economic determinants in Pakistani patients: A systematic review
   and meta-analysis
SO JOURNAL OF THE PAKISTAN MEDICAL ASSOCIATION
LA English
DT Review
DE Rheumatoid arthritis; Epidemiology; Prevalence; Socio-economic;
   Patients; Pakistan
ID RESTLESS LEGS SYNDROME; 2010 AMERICAN-COLLEGE; COST-OF-ILLNESS;
   RHEUMATOLOGY/EUROPEAN LEAGUE; CLASSIFICATION CRITERIA; METABOLIC
   SYNDROME; DIABETES-MELLITUS; CARE; PREVALENCE; DISEASE
AB Objectives: The study aimed to evaluate literature on rheumatoid arthritis disease in Pakistani patients, to have an understanding about its epidemiology, clinical aspects and socio-economic determinants.
   Methods: The review study was conducted from December 2017, to May 2018. An online search was conducted in international and local health databases using appropriate search keywords as well as scanning reference lists of related articles. Literature published after year 2000 that reported epidemiological, demographic, clinical and socioeconomic data of Pakistani rheumatoid arthritis patients was included. Meta-analysis was performed where possible. This systematic review was registered on the international prospective register of systematic reviews PROSPERO (CRD42018090582).
   Results: Of the 334 research articles found, 29 (8.7%) were selected. Patients were mostly females, but no study explored impact of disease on household and family role functioning of rheumatoid arthritis-affected women in Pakistan. Most patients were uneducated (55%) and unemployed; had low disease knowledge (N = 149, 74.5%) and poor adherence to disease-modifying anti-rheumatic drugs (N = 23, 23%). Point prevalence of rheumatoid arthritis reported from Karachi was high at 26.9%. Moderate disease activity, i.e., 4.5 +/- 0.7 and mild functional disability (N = 66, 51.6%) were seen in RA patients. Almost half (N = 799, 46.9%) had comorbidities. Almost a fifth proportion of RA patients had dyslipidaemia as a comorbidity (N = 134, 16.77%) and higher cardiovascular risk score as modifiable risk factor. Undiagnosed depression (N = 134, 58.3%) and low bone mineral density (N = 93, 40.6%) were reported in RA patients. Direct monthly treatment cost of disease was significantly high considering patients' socio-economic status, i.e., USD 16.47 - 100.68. Most commonly used drug was methotrexate.
   Conclusion: There is a paucity of data on Pakistani rheumatoid arthritis patients' demographic and socio-economic parameters, especially the gender element.
C1 [Naqvi, Atta Abbas; Hassali, Mohamed Azmi] USM, Discipline Social & Adm Pharm, Sch Pharmaceut Sci, George Town, Malaysia.
   [Aftab, Mohammad Tariq] Imam Abdul Rahman Bin Faisal Univ, Dept Pharmacol & Toxicol, Coll Med, Dammam, Saudi Arabia.
C3 Universiti Sains Malaysia; Imam Abdulrahman Bin Faisal University
RP Naqvi, AA (corresponding author), USM, Discipline Social & Adm Pharm, Sch Pharmaceut Sci, George Town, Malaysia.
EM naqviattaabbas@gmail.com
RI Hassali, Mohamed/A-6895-2011; Naqvi, Atta/G-1556-2019
CR Abbas A, 2013, MED J, V1, P82
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NR 73
TC 23
Z9 23
U1 0
U2 6
PU PAKISTAN MEDICAL ASSOC
PI KARACHI
PA PMA HOUSE, AGA KHAN III RD, KARACHI, 00000, PAKISTAN
SN 0030-9982
J9 J PAK MED ASSOC
JI J. Pak. Med. Assoc.
PD MAR
PY 2019
VL 69
IS 3
BP 389
EP 398
PG 10
WC Medicine, General & Internal; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Research & Experimental Medicine
GA HQ9XE
UT WOS:000462780600015
PM 30890833
DA 2025-06-11
ER

PT J
AU Xu, D
   Luo, HWW
   Hu, W
   Hu, SWW
   Yuan, C
   Wang, GHH
   Zhang, L
   Yu, H
   Magdalou, J
   Chen, LBB
   Wang, H
AF Xu, Dan
   Luo, Hanwen W.
   Hu, Wen
   Hu, Shuwei W.
   Yuan, Chao
   Wang, Guihua H.
   Zhang, Li
   Yu, Hong
   Magdalou, Jacques
   Chen, Liaobin B.
   Wang, Hui
TI Intrauterine programming mechanism for hypercholesterolemia in prenatal
   caffeine-exposed female adult rat offspring
SO FASEB JOURNAL
LA English
DT Article
DE glucocorticoids; cholesterol; epigenetic; HMGCR; C/EBP alpha
ID DENSITY-LIPOPROTEIN CHOLESTEROL; THRIFTY PHENOTYPE HYPOTHESIS;
   CARDIOVASCULAR RISK-FACTORS; METABOLIC SYNDROME; GROWTH RESTRICTION; DNA
   METHYLATION; EPIGENETIC MODIFICATION; PROTEIN RESTRICTION;
   GENE-EXPRESSION; FETAL
AB Clinical and animal studies have indicated that hypercholesterolemia and its associated diseases have intrauterine developmental origins. Our previous studies showed that prenatal caffeine exposure (PCE) led to fetal overexposure to maternal glucocorticoids (GCs) and increased serum total cholesterol levels in adult rat offspring. This study further confirms the intrauterine programming of PCE-induced hypercholesterolemia in female adult rat offspring. Pregnant Wistar rats were intragastrically administered caffeine (30, 60, and 120 mg/kg/d) from gestational day (GD)9 to 20. Female rat offspring were euthanized at GD20 and postnatal wk 12; several adult rat offspring were additionally subjected to ice-water swimming stimulation to induce chronic stress prior to death. The effects of GCs on cholesterol metabolism and epigenetic regulation were verified using the L02 cell line. The results showed that PCE induced hypercholesterolemia in adult offspring, which manifested as significantly higher levels of serum total cholesterol and LDL cholesterol (LDL-C) as well as higher ratios of LDL-C/HDL cholesterol. We further found that the cholesterol levels were increased in fetal livers but were decreased in fetal blood, accompanied by increased maternal blood cholesterol levels and reduced placental cholesterol transport. Furthermore, analysis of PCE offspring in the uterus and in a postnatal basal/chronic stress state and the results of in vitro experiments showed that hepatic cholesterol metabolism underwent GC-dependent changes and was associated with cholesterol synthase via abnormalities in 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) histone acetylation. We concluded that, to compensate for intrauterine placentally derived decreases in fetal blood cholesterol levels, high intrauterine GC levels activated fetal hepatic CCAAT enhancer binding protein signaling and down-regulated Sirtuin1 expression, which mediated the high levels of histone acetylation (via H3K9ac and H3K14ac) and expression of HMGCR. This GC-dependent cholesterol metabolism programming effect was sustained through adulthood, leading to the occurrence of hypercholesterolemia.Xu, D., Luo, H. W., Hu, W., Hu, S. W., Yuan, C., Wang, G. H., Zhang, L., Yu, H., Magdalou, J., Chen, L. B., Wang, H. Intrauterine programming mechanism for hypercholesterolemia in prenatal caffeine-exposed female adult rat offspring.
C1 [Xu, Dan; Luo, Hanwen W.; Hu, Wen; Hu, Shuwei W.; Yuan, Chao; Wang, Guihua H.; Zhang, Li; Wang, Hui] Wuhan Univ, Zhongnan Hosp, Basic Med Sch, Dept Pharmacol, Wuhan, Hubei, Peoples R China.
   [Xu, Dan; Yu, Hong; Chen, Liaobin B.; Wang, Hui] Wuhan Univ, Zhongnan Hosp, Dept Orthoped Surg, Wuhan, Hubei, Peoples R China.
   [Luo, Hanwen W.; Chen, Liaobin B.] Hubei Prov Key Lab Developmentally Originated Dis, Wuhan, Hubei, Peoples R China.
   [Magdalou, Jacques] Univ Lorraine, UMR 7365, CNRS, Fac Med, Vandoeuvre Les Nancy, France.
C3 Wuhan University; Wuhan University; Centre National de la Recherche
   Scientifique (CNRS); CNRS - Institute for Engineering & Systems Sciences
   (INSIS); Universite de Lorraine
RP Chen, LBB (corresponding author), Wuhan Univ, Zhongnan Hosp, Dept Orthopaed Surg, Wuhan 430071, Hubei, Peoples R China.; Wang, H (corresponding author), Wuhan Univ, Basic Med Sch, Dept Pharmacol, 185 East Lake Rd, Wuhan 430071, Hubei, Peoples R China.
EM lbchen@whu.edu.cn; wanghui19@whu.edu.cn
FU National Key Research and Development Program of China [2017YFC1001300];
   National Natural Science Foundation of China [81430089, 81673524,
   81671472]; Hubei Province Health and Family Planning Scientific Research
   Project [WJ2017C0003]
FX This work was supported by National Key Research and Development Program
   of China Grant 2017YFC1001300; National Natural Science Foundation of
   China Grants 81430089, 81673524, and 81671472; and Hubei Province Health
   and Family Planning Scientific Research Project Grant WJ2017C0003. The
   authors declare no conflicts of interest.
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NR 62
TC 22
Z9 23
U1 1
U2 21
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
EI 1530-6860
J9 FASEB J
JI Faseb J.
PD OCT
PY 2018
VL 32
IS 10
BP 5563
EP 5576
DI 10.1096/fj.201701557R
PG 14
WC Biochemistry & Molecular Biology; Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA GX7RI
UT WOS:000447972500030
PM 29718709
DA 2025-06-11
ER

PT J
AU Natarajan, V
   Master, V
   Ogan, K
AF Natarajan, Vivek
   Master, Viraj
   Ogan, Kenneth
TI Effects of Obesity and Weight Loss in Patients With Nononcological
   Urological Disease
SO JOURNAL OF UROLOGY
LA English
DT Review
DE urolithiasis; bariatric surgery; sexual dysfunction; physiological;
   prostatic hyperplasia; urinary incontinence
ID LIFE-STYLE CHANGES; RISK-FACTORS; INTRAABDOMINAL PRESSURE; ERECTILE
   DYSFUNCTION; METABOLIC SYNDROME; IMPACT; NEPHROLITHIASIS; SURGERY;
   WOMEN; SIZE
AB Purpose: We reviewed the effects of obesity and long-term weight loss on non-oncological urological disease, particularly urinary stone formation, erectile dysfunction, female sexual dysfunction, voiding dysfunction and urinary incontinence.
   Materials and Methods: A literature search was conducted using Ovid's MEDLINE (R), accessed through Emory University's Health Sciences Library web site. The subject headings obesity, weight loss surgery, urolithiasis, sexual dysfunction, erectile dysfunction, benign prostatic hyperplasia and urinary incontinence were used as indices for the search. Articles published earlier than 10 years before the literature review (performed in summer of 2007) were not used.
   Results: There is ample evidence to support an increased risk of urolithiasis in obese patients. However, the effects of long-term weight loss on urinary stone formation have not been studied as extensively in the literature. It is unclear whether the decreased food intake after surgical weight loss procedures may negate the associated risk of malabsorption and decrease the risk of urolithiasis in the long term.
   The incidence and severity of erectile dysfunction in men increase with obesity. Female sexual dysfunction also appears to be positively correlated with obesity, although the literature is less clear as to the extent to which this is true. Despite a scarcity of relevant data, preliminary evidence indicates that weight loss improves sexual function in men and women.
   Obesity is associated with an increased incidence of benign prostatic hyperplasia and subsequent lower urinary tract symptoms in men, as well as an increased incidence of stress urinary incontinence in women. Despite a lack of relevant data, there is preliminary evidence that stress urinary incontinence and benign prostatic hyperplasia may be reversible after weight loss.
   Conclusions: Despite the abundant evidence that indicates a correlation between obesity and several urological diseases, there is a paucity of data regarding the effects of long-term weight loss on these conditions. However, the preliminary data indicate that the detrimental effects of obesity are reversible, and that long-term weight loss may decrease the incidence and severity of urological disease. Therefore, further research is needed to elucidate the impact of long-term surgical and medical weight loss on urolithiasis, lower urinary tract symptoms and incontinence, and sexual dysfunction.
C1 [Natarajan, Vivek] Emory Univ, Sch Med, Dept Urol, Emory Clin, Atlanta, GA 30322 USA.
C3 Emory University
RP Natarajan, V (corresponding author), Emory Univ, Sch Med, Dept Urol, Emory Clin, 1365 Clifton Rd,Suite B, Atlanta, GA 30322 USA.
EM vnatar2@emory.edu
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NR 40
TC 12
Z9 14
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0022-5347
EI 1527-3792
J9 J UROLOGY
JI J. Urol.
PD JUN
PY 2009
VL 181
IS 6
BP 2424
EP 2429
DI 10.1016/j.juro.2009.01.107
PG 6
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 444ZX
UT WOS:000266020500007
PM 19371912
DA 2025-06-11
ER

PT J
AU Pedersen, NH
   Tarp, J
   Andersen, LB
   Gejl, AK
   Huang, T
   Peijs, L
   Bugge, A
AF Pedersen, Natascha Holbaek
   Tarp, Jakob
   Andersen, Lars Bo
   Gejl, Anne Kaer
   Huang, Tao
   Peijs, Lone
   Bugge, Anna
TI The association between serum brain-derived neurotrophic factor and a
   cluster of cardiovascular risk factors in adolescents: The CHAMPS-study
   DK
SO PLOS ONE
LA English
DT Article
ID TYPE-2 DIABETES-MELLITUS; INSULIN SENSITIVITY; METABOLIC SYNDROME; HUMAN
   PLATELETS; CHILDREN; BDNF; PLASMA; DEPRESSION; DISEASE
AB Background and objective
   Cardiovascular disease and type 2 diabetes pose a global health burden. Therefore, clarifying the pathology of these risk factors is essential. Previous studies have found positive and negative associations between one or more cardiovascular risk factors and brain-derived neurotrophic factor (BDNF) probably due to diverse methodological approaches when analysing peripheral BDNF levels. Moreover, only a few studies have been performed in youth populations. Consequently, the main objective of this study was to examine the association between serum BDNF and a composite z-score consisting of six cardiovascular risk factors. A secondary aim was to examine the associations between serum BDNF and each of the six risk factors.
   Methods
   Four hundred and forty-seven apparently healthy adolescents between 11-17 years of age participated in this cross-sectional study. Cardiorespiratory fitness (CRF), anthropometrics, pubertal status, blood pressure (BP), serum BDNF, high-density lipoprotein cholesterol (HDL-C), triglyceride (TG), blood glucose and insulin were measured. Information about alcohol consumption and socio-economic status was collected via questionnaires. Associations were modelled using linear regression analysis.
   Results
   Serum BDNF was positively associated with the composite z-score in the total study sample (standardized beta coefficient (std.beta) = 0.10, P = 0.037). In males, serum BDNF was positively associated with the composite z-score (Std. beta = 0.14, P = 0.034) and HOMA-IR (Std. beta = 0.19, P = 0.004), and negatively associated with CRF (Std. beta = - 0.15, P = 0.026). In females, BDNF was positively associated with TG (Std. beta = 0.14, P = 0.030) and negatively associated with waist circumference (WC) (Std. beta = - 0.16, P = 0.012).
   Conclusion
   Serum BDNF was positively associated with a composite z-score of cardiovascular risk factors. This association seems to be mainly driven by the association between TG, HOMA-IR and serum BDNF, and particularly for males. Further longitudinal research is warranted to determine the temporal relationship between BDNF and cardiovascular risk factors.
C1 [Pedersen, Natascha Holbaek; Tarp, Jakob; Gejl, Anne Kaer; Bugge, Anna] Univ Southern Denmark, Dept Sports Sci & Clin Biomech, Ctr Res Childhood Hlth, Odense, Denmark.
   [Andersen, Lars Bo] Western Norway Univ Appl Sci, Dept Teacher Educ & Sport, Campus Sogndal, Bergen, Norway.
   [Andersen, Lars Bo] Norwegian Sch Sport Sci, Dept Sports Med, Oslo, Norway.
   [Huang, Tao] Shanghai Jiao Tong Univ, Dept Phys Educ, Shanghai, Peoples R China.
   [Peijs, Lone] Univ Copenhagen, Dept Infect Dis, Ctr Phys Act Res, Rigshosp, Copenhagen, Denmark.
C3 University of Southern Denmark; Western Norway University of Applied
   Sciences; Norwegian School of Sport Sciences; Shanghai Jiao Tong
   University; University of Copenhagen; Copenhagen University Hospital;
   Rigshospitalet
RP Pedersen, NH (corresponding author), Univ Southern Denmark, Dept Sports Sci & Clin Biomech, Ctr Res Childhood Hlth, Odense, Denmark.
EM nhpedersen@health.sdu.dk
RI ; Bugge, Anna/P-5100-2016; Peijs, Lone/P-7161-2018
OI Kaer Gejl, Anne/0000-0001-6781-2263; Pedersen, Natascha
   Holbaek/0000-0003-4260-3240; Tarp, Jakob/0000-0002-9186-7077; Bugge,
   Anna/0000-0002-8345-1434; Peijs, Lone/0000-0002-7953-1976
FU TrygFonden [104982]; TrygFonden
FX CHAMPS Ill was supported by the TrygFonden (104982), www.trygfonden.dk.
   The funding source had no involvement in the article. During the study
   period, the Centre for Physical Activity Research (CFAS) was supported
   by a grant from TrygFonden, www.trygfonden.dk.
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NR 41
TC 14
Z9 15
U1 0
U2 3
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD OCT 13
PY 2017
VL 12
IS 10
AR e0186384
DI 10.1371/journal.pone.0186384
PG 12
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA FJ7ZQ
UT WOS:000412980300032
PM 29028824
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Arver, S
   Luong, B
   Fraschke, A
   Ghatnekar, O
   Stanisic, S
   Gultyev, D
   Müller, E
AF Arver, Stefan
   Luong, Ba
   Fraschke, Anina
   Ghatnekar, Ola
   Stanisic, Sanja
   Gultyev, Dmitry
   Mueller, Elvira
TI Is Testosterone Replacement Therapy in Males with Hypogonadism
   Cost-Effective? An Analysis in Sweden
SO JOURNAL OF SEXUAL MEDICINE
LA English
DT Article
DE Testosterone Replacement Therapy; Cost-Effectiveness; Hypogonadism;
   Sweden; Long-Term Implications
ID QUALITY-OF-LIFE; LATE-ONSET HYPOGONADISM; CORONARY-HEART-DISEASE;
   HORMONE-BINDING GLOBULIN; METABOLIC SYNDROME; ANDROGEN DEFICIENCY;
   DEPRESSIVE-ILLNESS; DIABETES-MELLITUS; SEXUAL FUNCTION; MEN
AB Introduction
   Testosterone replacement therapy (TRT) has been recommended for the treatment of primary and secondary hypogonadism. However, long-term implications of TRT have not been investigated extensively.
   Aim
   The aim of this analysis was to evaluate health outcomes and costs associated with life-long TRT in patients suffering from Klinefelter syndrome and late-onset hypogonadism (LOH).
   Methods
   A Markov model was developed to assess cost-effectiveness of testosterone undecanoate (TU) depot injection treatment compared with no treatment. Health outcomes and associated costs were modeled in monthly cycles per patient individually along a lifetime horizon. Modeled health outcomes included development of type 2 diabetes, depression, cardiovascular and cerebrovascular complications, and fractures. Analysis was performed for the Swedish health-care setting from health-care payer's and societal perspective. One-way sensitivity analyses evaluated the robustness of results.
   Main Outcome Measures
   The main outcome measures were quality-adjusted life-years (QALYs) and total cost in TU depot injection treatment and no treatment cohorts. In addition, outcomes were also expressed as incremental cost per QALY gained for TU depot injection therapy compared with no treatment (incremental cost-effectiveness ratio [ICER]).
   Results
   TU depot injection compared to no-treatment yielded a gain of 1.67 QALYs at an incremental cost of 28,176 EUR (37,192 USD) in the Klinefelter population. The ICER was 16,884 EUR (22,287 USD) per QALY gained. Outcomes in LOH population estimated benefits of TRT at 19,719 EUR (26,029 USD) per QALY gained. Results showed to be considerably robust when tested in sensitivity analyses. Variation of relative risk to develop type 2 diabetes had the highest impact on long-term outcomes in both patient groups.
   Conclusion
   This analysis suggests that lifelong TU depot injection therapy of patients with hypogonadism is a cost-effective treatment in Sweden. Hence, it can support clinicians in decision making when considering appropriate treatment strategies for patients with testosterone deficiency.
C1 [Arver, Stefan] Karolinska Univ Hosp Huddinge, Ctr Androl & Sexual Med, Stockholm, Sweden.
   [Arver, Stefan] Karolinska Inst, Dept Med, Stockholm, Sweden.
   [Luong, Ba] Bayer Pharma AG, D-13353 Berlin, Germany.
   [Fraschke, Anina] Bayer AB, Solna, Sweden.
   [Ghatnekar, Ola] Swedish Inst Hlth Econ, Lund, Sweden.
   [Stanisic, Sanja; Gultyev, Dmitry; Mueller, Elvira] Analyt LA SER Int Inc, Lorrach, Germany.
C3 Karolinska Institutet; Karolinska University Hospital; Karolinska
   Institutet; Bayer AG; Bayer Healthcare Pharmaceuticals; Bayer AG
RP Luong, B (corresponding author), Bayer Pharma AG, Mullerstr 178, D-13353 Berlin, Germany.
EM ba.luong@bayer.com
OI Arver, Stefan/0000-0002-2925-355X
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   [No title captured]
NR 60
TC 17
Z9 18
U1 0
U2 6
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1743-6095
EI 1743-6109
J9 J SEX MED
JI J. Sex. Med.
PD JAN
PY 2014
VL 11
IS 1
BP 262
EP 272
DI 10.1111/jsm.12277
PG 11
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA AE9ML
UT WOS:000334331800030
PM 23937088
DA 2025-06-11
ER

PT J
AU Heaton, RK
   Ellis, RJ
   Tang, B
   Marra, CM
   Rubin, LH
   Clifford, DB
   McCutchan, JA
   Gelman, BB
   Morgello, S
   Franklin, DR
   Letendre, SL
AF Heaton, Robert K.
   Ellis, Ronald J.
   Tang, Bin
   Marra, Christina M.
   Rubin, Leah H.
   Clifford, David B.
   McCutchan, J. Allen
   Gelman, Benjamin B.
   Morgello, Susan
   Franklin, Donald R.
   Letendre, Scott L.
TI Twelve-year neurocognitive decline in HIV is associated with
   comorbidities, not age: a CHARTER study
SO BRAIN
LA English
DT Article
DE HIV; neurologic complications; cognition; brain
ID HUMAN-IMMUNODEFICIENCY-VIRUS; ACTIVE ANTIRETROVIRAL THERAPY;
   RISK-FACTORS; METABOLIC SYNDROME; DEFICIT SCORES; OLDER AGE; IMPAIRMENT;
   INFECTION; INDIVIDUALS; INFLAMMATION
AB In a longitudinal study following more than 400 people with HIV (people with HIV) over 12 years, Heaton et al. find that cognitive decline is not associated with chronological age, but with comorbidities. This is inconsistent with premature cognitive ageing due to HIV, and suggests that comorbidity management may prevent cognitive decline in people with HIV.
   Modern antiretroviral therapy (ART) has increased longevity of people with HIV and shifted the age distribution of the HIV pandemic upward toward that of the general population. This positive development has also led to concerns about premature and/or accelerated neurocognitive and physical ageing due to the combined effects of chronic HIV, accumulating comorbidities, adverse effects or possible toxicities of ART and biological ageing. Here we present results of comprehensive assessments over 12 years of 402 people with HIV in the CNS HIV ART Effects Research (CHARTER) programme, who at follow-up were composed of younger (<60 years) and older (>= 60 years) subgroups. Over the 12 years, ART use and viral suppression increased in both subgroups as did systemic and psychiatric comorbidities; participants in both subgroups also evidenced neurocognitive decline beyond what is expected in typical ageing. Contrary to expectations, all these adverse effects were comparable in the younger and older CHARTER subgroups, and unrelated to chronological age. Neurocognitive decline was unrelated to HIV disease or treatment characteristics but was significantly predicted by the presence of comorbid conditions, specifically diabetes, hypertension, chronic pulmonary disease, frailty, neuropathic pain, depression and lifetime history of cannabis use disorder. These results are not consistent with premature or accelerated neurocognitive ageing due to HIV itself but suggest important indirect effects of multiple, potentially treatable comorbidities that are more common among people with HIV than in the general population. Good medical management of HIV disease did not prevent these adverse outcomes, and increased attention to a range of comorbid conditions in people with HIV may be warranted in their care.
C1 [Heaton, Robert K.; Ellis, Ronald J.; Tang, Bin; Franklin, Donald R.; Letendre, Scott L.] Univ Calif San Diego, Dept Psychiat, San Diego, CA 92093 USA.
   [Ellis, Ronald J.] Univ Calif San Diego, Dept Neurosci, San Diego, CA 92093 USA.
   [Marra, Christina M.] Univ Washington, Dept Neurol, Seattle, WA 98104 USA.
   [Rubin, Leah H.] Johns Hopkins Univ, Dept Neurol, Baltimore, MD 21218 USA.
   [Clifford, David B.] Washington Univ St Louis, Dept Neurol, St Louis, MO 63110 USA.
   [McCutchan, J. Allen; Letendre, Scott L.] Univ Calif San Diego, Dept Med, San Diego, CA 92093 USA.
   [Gelman, Benjamin B.] Univ Texas Med Branch, Dept Pathol, Galveston, TX 77555 USA.
   [Gelman, Benjamin B.] Univ Texas Med Branch, Dept Neurosci & Cell Biol, Galveston, TX 77555 USA.
   [Morgello, Susan] Icahn Sch Med Mt Sinai, Dept Neurol, New York, NY 10029 USA.
   [Letendre, Scott L.] Univ Calif San Diego, 220 Dickinson St Suite A, San Diego, CA 92103 USA.
C3 University of California System; University of California San Diego;
   University of California System; University of California San Diego;
   University of Washington; University of Washington Seattle; Johns
   Hopkins University; Washington University (WUSTL); University of
   California System; University of California San Diego; University of
   Texas System; University of Texas Medical Branch Galveston; University
   of Texas System; University of Texas Medical Branch Galveston; Icahn
   School of Medicine at Mount Sinai; University of California System;
   University of California San Diego
RP Letendre, SL (corresponding author), Univ Calif San Diego, 220 Dickinson St Suite A, San Diego, CA 92103 USA.
EM sletendre@ucsd.edu
RI S, M/JTT-7083-2023; Letendre, Scott/GLU-6874-2022; Ellis,
   Ronald/K-3543-2015
OI Ellis, Ronald/0000-0003-4931-752X
FU National Institute of Mental Health [R01 MH107345, P30 MH062512]
FX The authors gratefully acknowledge funding from the National Institute
   of Mental Health (R01 MH107345, P30 MH062512).
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NR 59
TC 30
Z9 33
U1 1
U2 5
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0006-8950
EI 1460-2156
J9 BRAIN
JI Brain
PD MAR 1
PY 2023
VL 146
IS 3
BP 1121
EP 1131
DI 10.1093/brain/awac465
EA JAN 2023
PG 11
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 9M9DV
UT WOS:000919006800001
PM 36477867
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Sacchetti, E
   Galluzzo, A
   Valsecchi, P
   Romeo, F
   Gorini, B
   Warrington, L
AF Sacchetti, Emilio
   Galluzzo, Alessandro
   Valsecchi, Paolo
   Romeo, Fabio
   Gorini, Barbara
   Warrington, Lewis
CA INITIATE Study Grp
TI Ziprasidone vs clozapine in schizophrenia patients refractory to
   multiple antipsychotic treatments: The MOZART study
SO SCHIZOPHRENIA RESEARCH
LA English
DT Article
DE Ziprasidone; Clozapine; Treatment resistance; Tolerability
ID TREATMENT-RESISTANT SCHIZOPHRENIA; DRUG-NAIVE PATIENTS; DEPRESSION
   RATING-SCALE; NEGATIVE SYNDROME SCALE; DOUBLE-BLIND; METABOLIC SYNDROME;
   ATYPICAL ANTIPSYCHOTICS; GLUCOSE-TOLERANCE; DIABETES-MELLITUS; PHYSICAL
   HEALTH
AB This 18-week, randomized, flexible-dose, double-blind, double-dummy trial evaluated ziprasidone as an alternative to clozapine in treatment-refractory schizophrenia patients. Patients had a DSM-IV diagnosis of schizophrenia, a history of resistance and/or intolerance to at least three acute cycles with different antipsychotics given at therapeutic doses, PANSS score >= 80, and CGI-S score >= 4. Patients were randomized to ziprasidone (80-160 mg/day, n=73) or clozapine (250-600 mg/day, n=74). On the primary ITT-LOCF analysis, baseline-to-endpoint decreases in PANSS total scores were similar in the ziprasidone (-25.0 +/- 22.0, 95% CI -30.2 to -19.8) and clozapine (-24.5 +/- 22.5, 95% CI -29.7 to -19.2) groups. A progressive and significant reduction from baseline in PANSS total score was observed from day 11 in both study arms. There were also significant improvements on PANSS subscales, CGI-S, CG-I, CDSS, and GAF, without between-drug differences. The two treatment groups had similar rates of early discontinuations due to AEs. AEs were mostly of similar mild-moderate severity in the two groups. There were also no detrimental effects on prolactin, renal and liver function, hematology, and cardiovascular parameters. However, ziprasidone but not clozapine showed a significant reduction of SAS and AIMS scores. Moreover, when compared with clozapine, ziprasidone also had a more favorable metabolic profile, with significant endpoint differences in weight, fasting glucose, total cholesterol, LDL cholesterol, and triglycerides. In conclusion, this trial indicates that both ziprasidone and clozapine, having comparable efficacy coupled with satisfactory general safety and tolerability, may be regarded as valuable options for the short-term treatment of difficult-to-treat schizophrenia patients with a history of multiple resistance and/or intolerance to antipsychotics. The more favorable metabolic profile of ziprasidone may represent an added value that could guide clinicians, at least in the presence of patients at high risk for metabolic disorders. (c) 2009 Elsevier B.V. All rights reserved.
C1 [Sacchetti, Emilio; Galluzzo, Alessandro; Valsecchi, Paolo] Univ Brescia, Sch Med, Univ Psychiat Unit, I-25133 Brescia, Italy.
   [Sacchetti, Emilio] Univ Brescia, Sch Med, Chair Psychiat, I-25133 Brescia, Italy.
   [Sacchetti, Emilio; Galluzzo, Alessandro; Valsecchi, Paolo] Brescia Spedali Civili, Dept Mental Hlth, Brescia, Italy.
   [Sacchetti, Emilio] Univ Brescia, Ctr Behav & Neurodegenerat Disorders, I-25133 Brescia, Italy.
   [Sacchetti, Emilio] EULO, Brescia, Italy.
   [Gorini, Barbara] Pfizer Italia, Dept Med, Rome, Italy.
   [Warrington, Lewis] Pfizer Inc, New York, NY USA.
C3 University of Brescia; University of Brescia; Hospital Spedali Civili
   Brescia; University of Brescia; Pfizer; Pfizer Italy; Pfizer; Pfizer USA
RP Sacchetti, E (corresponding author), Univ Brescia, Sch Med, Univ Psychiat Unit, Ple Speclali Civili 1, I-25133 Brescia, Italy.
EM sacchett@med.unibs.it
RI Galluzzo, Alessandro/B-5257-2012
OI NIOLU, CINZIA/0000-0001-6173-2684
FU Pfizer, Italy
FX This study was funded by Pfizer, Italy and carried out with the support
   of Pfizer, Inc. Prof. Sacchetti, Drs. Galluzzo and Valsecchi, and the
   Investigator of the MOZART Study Group have all worked as consultants
   for Pfizer, Italy. Drs. Romeo, Gorini and Warrington are or were full
   time employees of Pfizer, Italy or Pfizer Inc at the time of the study
   and development of this manuscript.
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NR 70
TC 24
Z9 25
U1 0
U2 5
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0920-9964
EI 1573-2509
J9 SCHIZOPHR RES
JI Schizophr. Res.
PD MAY
PY 2009
VL 110
IS 1-3
BP 80
EP 89
DI 10.1016/j.schres.2009.02.017
PG 10
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 463MZ
UT WOS:000267437600010
PM 19269791
OA Green Published
DA 2025-06-11
ER

PT J
AU Ghaemi, A
   Taleban, FA
   Hekmatdoost, A
   Rafiei, A
   Hosseini, V
   Amiri, Z
   Homayounfar, R
   Fakheri, H
AF Ghaemi, Alireza
   Taleban, Fourugh Azam
   Hekmatdoost, Azita
   Rafiei, Alireza
   Hosseini, Vahid
   Amiri, Zohreh
   Homayounfar, Reza
   Fakheri, Hafez
TI How Much Weight Loss is Effective on Nonalcoholic Fatty Liver Disease?
SO HEPATITIS MONTHLY
LA English
DT Article
DE Nonalcoholic Fatty Liver Disease; Diet; Weight Loss
ID BODY-MASS INDEX; OXIDATIVE STRESS; ALANINE AMINOTRANSFERASE; INSULIN
   SENSITIVITY; METABOLIC SYNDROME; PHYSICAL-ACTIVITY; STEATOHEPATITIS;
   POPULATION; SERUM; PATHOGENESIS
AB Background: Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide with no specific treatment. Weight loss is the most effective therapeutic strategy in its management; however, there is no consensus on its specifics. Thus, this study was conducted to evaluate the effects of weight loss on liver enzymes, markers of inflammation, oxidative stress and CK18-M30 (cytokeratin 18) as a biomarker of hepatocellular apoptosis.
   Objectives: To study the effect of weight reduction diet as an exclusive treatment for NAFLD.
   Patients and Methods: Forty four patients with NAFLD received a diet including a 500 to 1000 kcal per day intake reduction as30% fat, 15% protein, and 55% carbohydrate for six months. Anthropometric parameters, alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma glutamyl transferase (GGT), lipid profile, malondialdehyde (MDA), TNF-alpha, IL-6, CK18-M30 were measured at baseline and at the end of the study. At the end of follow up, patients were classified as adherent or nonadherent to treatment according to a weight loss of >= 5%, or <5% of initial body weight, respectively.
   Results: Twenty five patients were classified as adherent group and nineteen as nonadherent group (9.7% vs. 1.9% total body weight loss after 6 months, respectively). After 6 months, changes in adherent and nonadherent groups were as follows: reduction in body weight from 93.7 +/- 15.8 kg to 84.2 +/- 13.4 kg vs. 94 +/- 16.6 kg to 92.2 +/- 16.2 kg (P < 0.05), BMI from 32.7 +/- 3.9 to 29.5 +/- 3.2 vs. 31.8 +/- 5.4 to 31.1 +/- 5.3 (P < 0.001), and waist circumference from 105.1 +/- 12.6 cm to 97.4 +/- 9.8 cm vs. 106.8 +/- 14.2 cm to 103.7 +/- 14 cm (P < 0.001), respectively. Diastolic blood pressure was significantly decreased in adherent group (from 80.2 +/- 5.1 mmHg to 76.9 +/- 5 mmHg; P < 0.001). Also, total cholesterol, LDL, triglyceride, ALT, AST, GGT and CK18-M30 levels were significantly decreased in the adherent group compared to nonadherent group (P < 0.05).
   Conclusions: This intervention offers a practical approach for treatment of patients with NAFLD with diet therapy.
C1 [Ghaemi, Alireza; Taleban, Fourugh Azam; Hekmatdoost, Azita] Shahid Beheshti Univ Med Sci, Fac Nutr Sci & Food Technol, Natl Nutr & Food Technol Res Inst, Dept Clin Nutr & Dietet, Tehran, Iran.
   [Rafiei, Alireza] Mazandaran Univ Med Sci, Fac Med, Mol & Cell Biol Ctr, Sari, Iran.
   [Hosseini, Vahid; Fakheri, Hafez] Mazandaran Univ Med Sci, Inflammatory Dis Upper Gastrointestinal Tract Res, Sari, Iran.
   [Amiri, Zohreh; Homayounfar, Reza] Shahid Beheshti Univ Med Sci, Fac Nutr Sci & Food Technol, Natl Nutr & Food Technol Res Inst, Dept Basic Sci, Tehran, Iran.
C3 Shahid Beheshti University Medical Sciences; Mazandaran University of
   Medical Sciences; Mazandaran University of Medical Sciences; Shahid
   Beheshti University Medical Sciences
RP Fakheri, H (corresponding author), Mazandaran Univ Med Sci, Inflammatory Dis Upper Gastrointestinal Tract Res, Sari, Iran.
EM fakher42@yahoo.com
RI Fakheri, Hafez/G-7638-2017; Rafiei, Alireza/A-2314-2009; Hosseini,
   Vahid/C-3468-2008; Hekmatdoost, Azita/AGM-6497-2022; Homayounfar,
   Reza/L-8813-2017; Ghaemi, Alireza/J-9577-2016
OI Hekmatdoost, Azita/0000-0002-1944-0052; Homayounfar,
   Reza/0000-0001-5398-9519; Ghaemi, Alireza/0000-0001-6132-1068
FU National Nutrition and Food Technology Research Institute, Faculty of
   Nutrition Sciences and Food Technology, Shahid Beheshti University of
   Medical Sciences, Tehran, IR Iran; Mazandaran University of Medical
   Sciences, Sari, IR Iran
FX This study was financially supported by National Nutrition and Food
   Technology Research Institute, Faculty of Nutrition Sciences and Food
   Technology, Shahid Beheshti University of Medical Sciences, Tehran, IR
   Iran and Mazandaran University of Medical Sciences, Sari, IR Iran.
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NR 44
TC 59
Z9 62
U1 0
U2 11
PU KOWSAR PUBL
PI HOENSBROEK
PA PATERSWEG 22,, HOENSBROEK, LIMBURG 6431 GC, NETHERLANDS
SN 1735-143X
EI 1735-3408
J9 HEPAT MON
JI Hepat. Mon.
PD DEC
PY 2013
VL 13
IS 12
AR e15227
DI 10.5812/hepatmon.15227
PG 9
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 273LO
UT WOS:000328536500008
PM 24358045
OA Green Submitted, Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Mattsson, C
   Reynolds, RM
   Simonyte, K
   Olsson, T
   Walker, BR
AF Mattsson, Cecilia
   Reynolds, Rebecca M.
   Simonyte, Kotryna
   Olsson, Tommy
   Walker, Brian R.
TI Combined Receptor Antagonist Stimulation of the
   Hypothalamic-Pituitary-Adrenal Axis Test Identifies Impaired Negative
   Feedback Sensitivity to Cortisol in Obese Men
SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Article
ID BODY-FAT DISTRIBUTION; MINERALOCORTICOID RECEPTOR;
   GLUCOCORTICOID-RECEPTOR; BASAL ACTIVITY; DOSE-RESPONSE; PLASMA ACTH;
   SECRETION; HUMANS; RU-486; DEXAMETHASONE
AB Context: Hypothalamic-pituitary-adrenal (HPA) axis dysregulation may underlie disorders including obesity, depression, cognitive decline, and the metabolic syndrome. Conventional tests of HPA axis negative feedback rely on glucocorticoid receptor (GR) agonists such as dexamethasone but do not test feedback by endogenous cortisol, potentially mediated by both GR and mineralocorticoid receptors (MR).
   Objective: The objective of the study was to use a combination of GR (RU38486, mifepristone) and MR (spironolactone) antagonists to explore the poorly understood activation of the HPA axis that occurs in obesity.
   Design: This was a double-blind, placebo-controlled, randomized, crossover study.
   Setting: The study was conducted at a clinical research facility.
   Participants: Participants included 15 lean (body mass index 22.0 +/- 1.6 kg/m(2)) and 16 overweight/obese (body mass index 30.1 +/- 3.5 kg/m2) men.
   Intervention: Subjects attended on four occasions for blood and saliva sampling every 30 min between 1800 and 2200 h. At 1100 and 1600 h before visits, subjects took 200 mg spironolactone, 400 mg RU38486, 200 mg spironolactone + 400 mg RU38486, or placebo orally.
   Main Outcome Measures: Serum cortisol levels after drug or placebo were measured.
   Results: Cortisol levels did not differ between lean and obese after placebo. Spironolactone and RU38486 alone had modest effects, increasing cortisol by less than 50% in both groups. However, combined spironolactone plus RU38486 elevated cortisol concentrations substantially, more so in lean than obese men [2.9- (0.3) vs. 2.2 (0.3)-fold elevation, P = 0.002].
   Conclusions: Combined receptor antagonist stimulation of the HPA axis reveals redundancy of MR and GR in negative feedback in humans. Obese men have impaired responses to combined receptor antagonist stimulation, suggesting impaired negative feedback by endogenous cortisol. Such an approach may be useful to dissect abnormal HPA axis control in neuropsychiatric and other disorders. (J Clin Endocrinol Metab 94: 1347-1352, 2009)
C1 [Reynolds, Rebecca M.; Walker, Brian R.] Univ Edinburgh, Endocrinol Unit, Ctr Cardiovasc Sci, Queens Med Res Inst, Edinburgh EH16 4TJ, Midlothian, Scotland.
   [Mattsson, Cecilia; Simonyte, Kotryna; Olsson, Tommy] Umea Univ Hosp, Dept Publ Hlth & Clin Med, S-90185 Umea, Sweden.
C3 University of Edinburgh; Umea University; Umea University Hospital
RP Reynolds, RM (corresponding author), Univ Edinburgh, Endocrinol Unit, Ctr Cardiovasc Sci, Queens Med Res Inst, 47 Little France Crescent, Edinburgh EH16 4TJ, Midlothian, Scotland.
EM r.reynolds@ed.ac.uk
RI Olsson, Tommy/KCZ-0891-2024; Simonyté Sjödin, Kotryna/CAI-1642-2022;
   Reynolds, Rebecca M/C-3044-2008
OI Reynolds, Rebecca M/0000-0001-6226-8270; Olsson,
   Tommy/0000-0001-7768-1076
FU Medical Faculty of Umea University; British Heart Foundation
FX This work was supported by grants from the Medical Faculty of Umea
   University and the British Heart Foundation.
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NR 33
TC 42
Z9 46
U1 0
U2 3
PU ENDOCRINE SOC
PI CHEVY CHASE
PA 8401 CONNECTICUT AVE, SUITE 900, CHEVY CHASE, MD 20815-5817 USA
SN 0021-972X
EI 1945-7197
J9 J CLIN ENDOCR METAB
JI J. Clin. Endocrinol. Metab.
PD APR
PY 2009
VL 94
IS 4
BP 1347
EP 1352
DI 10.1210/jc.2008-2054
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 432PB
UT WOS:000265145100047
PM 19141586
OA Bronze
DA 2025-06-11
ER

PT J
AU Liang, X
   Wang, Q
   Jiang, ZQ
   Li, ZQ
   Zhang, MX
   Yang, PY
   Wang, X
   Wang, YQ
   Qin, YH
   Li, TX
   Zhang, TY
   Wang, Y
   Sun, JX
   Li, YS
   Luo, H
   Li, LR
AF Liang Xue
   Wang Qi
   Jiang Zeqiang
   Li Zhuqing
   Zhang Mengxing
   Yang Peiying
   Wang Xin
   Wang Yanqiu
   Qin Yuehua
   Li Tianxing
   Zhang Tianyi
   Wang Yi
   Sun Jianxiang
   Li Yusi
   Luo Hui
   Li Lingru
TI Clinical research linking Traditional Chinese Medicine constitution
   types with diseases: a literature review of 1639 observational studies
SO JOURNAL OF TRADITIONAL CHINESE MEDICINE
LA English
DT Review
DE Body constitution; Medicine; Chinese traditional; Clinical study; Review
ID HEALTH
AB OBJECTIVE: To analyze clinical studies on correlations between Traditional Chinese Medicine (TCM) body constitution types and diseases published in the past 10 years, and to provide an evidence base to support the use of such correlations for health maintenance and disease prevention.
   METHODS: We searched five databases for the period April 2009 to December 2019: China National Knowledge Infrastructure Database, Wanfang Database, China Science and Technology Journal Database, PubMed and Embase. Three types of observational studies on correlation between constitution types and diseases were included: cross-sectional, case-control and cohort studies. Descriptive statistical methods were employed for data analysis.
   RESULTS: A total of 1639 clinical studies were identified: 1452 (88.59%) cross-sectional studies, 115 (7.02%) case-control studies and 72 (4.39%) cohort studies covering 30 regions of China and five other countries (Malaysia, South Korea, Singapore, Thailand and France). The collection of studies comprised 19 disease categories and 333 different diseases. The 10 most commonly studied diseases were hypertension, diabetes, stroke, coronary atherosclerotic heart disease (CAHD), sleep disorders, neoplasm of the breast, dysmenorrhea, fatty liver disease, chronic viral hepatitis B and dyslipidemia. We found high distributions for each biased constitution type in different patient populations as follows: Qi-deficiency constitution in stroke, diabetes, chronic obstructive pulmonary disease, acquired immunodeficiency syndrome and hypertension; Yang-deficiency constitution in female infertility, osteoporosis, irritable bowel syndrome, gonarthrosis and dysmenorrhea; Yin-deficiency constitution in hypertension, diabetes, constipation, female climacteric states and osteoporosis; phlegm- dampness constitution in hypertension, stroke, fatty liver disease, diabetes and metabolic syndrome; damp-heat constitution in acne, chronic gastritis, chronic viral hepatitis B, human papillomavirus infection and hyperuricemia; blood-stasis constitution in CAHD, endometriosis and stroke; Qi-stagnation constitution in hyperplasia and neoplasms of the breast, insomnia, depression and thyroid nodules; and inherited-special constitution in asthma and allergic rhinitis.
   CONCLUSION: Eight biased TCM constitutions were closely related to specific diseases, and could be used to guide individualized prevention and treatment. More rigorously designed studies are recommended to further verify the constitution-disease relationship. (C) 2020 JTCM. All rights reserved.
C1 [Liang Xue; Wang Qi; Jiang Zeqiang; Li Zhuqing; Zhang Mengxing; Yang Peiying; Wang Xin; Wang Yanqiu; Qin Yuehua; Li Tianxing; Zhang Tianyi; Wang Yi; Sun Jianxiang; Li Yusi; Li Lingru] Beijing Univ Chinese Med, Ctr Studies Constitut Res & Reprod Sci Tradit Chi, Beijing 100029, Peoples R China.
   [Luo Hui] China Tibetol Res Ctr, Inst Tibetan Med, Beijing 100101, Peoples R China.
C3 Beijing University of Chinese Medicine
RP Li, LR (corresponding author), Beijing Univ Chinese Med, Ctr Studies Constitut Res & Reprod Sci Tradit Chi, Beijing 100029, Peoples R China.; Luo, H (corresponding author), China Tibetol Res Ctr, Beijing 100101, Peoples R China.
EM luohui09@hotmail.com; lilingru912@163.com
RI Ling, Li/JYO-7043-2024; Zhang, Tianyi/AAG-6220-2021; Li,
   Lingru/ABF-3023-2020; Zhang, Mengxing/LMN-6106-2024; Li,
   Tianxing/AAL-7163-2020
FU Key Program of the National Natural Science Foundation of China
   [81730112]; Innovation Team Project of Beijing University of Chinese
   Medicine [2019-JYB-TD010]
FX Supported by the Key Program of the National Natural Science Foundation
   of China (the Biological Basis of Phlegm-dampness Constitution
   Susceptible to Metabolic Disease and Mechanism of Preventive Treatment
   of Disease by Adjusting Constitution; No. 81730112); Innovation Team
   Project of Beijing University of Chinese Medicine (Basic Research on
   Prevention and Treatment of Diseases by Regulating TCM Constitution; No.
   2019-JYB-TD010)
CR [Anonymous], 2018, CHIN PUB ADM REV-US
   [Anonymous], 2017, MED LONG TERM PLAN P
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NR 36
TC 76
Z9 86
U1 16
U2 113
PU JOURNAL TRADITIONAL CHINESE MED
PI BEIJING
PA 16 NANXIAOJIE, DONGZHIMEN NEI, BEIJING, 100700, PEOPLES R CHINA
SN 0255-2922
EI 1577-7014
J9 J TRADIT CHIN MED
JI J. Tradit. Chin. Med.
PD AUG
PY 2020
VL 40
IS 4
BP 690
EP 702
PG 13
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA MP5RM
UT WOS:000552261500019
PM 32744037
DA 2025-06-11
ER

PT J
AU Fond, G
   Tinland, A
   Boucekine, M
   Girard, V
   Loubière, S
   Boyer, L
   Auquier, P
AF Fond, G.
   Tinland, A.
   Boucekine, M.
   Girard, V
   Loubiere, S.
   Boyer, L.
   Auquier, P.
CA French Housing First Study Grp
TI The need to improve detection and treatment of physical pain of homeless
   people with schizophrenia and bipolar disorders. Results from the French
   Housing First Study
SO PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
LA English
DT Article
DE Schizophrenia; Bipolar disorders; Homelessness; Physical pain; EQ5D
ID MAJOR DEPRESSIVE DISORDER; METABOLIC SYNDROME; BACK-PAIN; METAANALYSIS;
   HEALTH; FIBROMYALGIA; SENSITIVITY; PREVALENCE; VALIDATION; MEDICATION
AB Objective: The aim of this study was to investigate the prevalence and associated factors of physical pain in a large multicenter sample of Homeless Schizophrenia and Bipolar (HSB) patients.
   Methods: This multicenter study was conducted in 4 French cities: Lille, Marseille, Paris and Toulouse. Pain was measured by EQ5D-3 L questionnaire with no specified period or location. In addition, sociodemographic information, duration of homelessness, illness severity using the Modified Colorado Symptom Index (MCSI) and drug information were collected.
   Results: Overall, 655 HSB patients, mean age 38.8 years and 82.6% men were included, 448 (68.9%) were diagnosed with schizophrenia and 202 (31.1%) with bipolar disorder. More than half patients (N = 337, 51.5%) reported moderate to extreme physical pain while only 2.7% were administered analgesic drugs. In the multivariate analysis, self-reported moderate to extreme physical pain was associated with antidepressant consumption (adjusted odd ratio aOR = 2.56[1.25;5.26], p = .01), female gender (aOR = 1.72[1.03;2.86], p = .04), bipolar disorders (vs. schizophrenia) (aOR = 1.81[1.19;2.77], p = .006), older age (aOR = 1.03 [1.01;1.05], p = .01), with higher MCSI psychotic score (aOR = 1.04[1.01;1.06], p = .002), independently of the number of days in the street during the last 180 days, MCSI depression score, alcohol and substance use disorders, psychotropic drugs and analgesic treatments. No association with education level, antipsychotics, mood stabilizers, anxiolytic, hypnotic or medication adherence was found (all p > .05).
   Conclusion: Physical pain was highly reported in homeless patients with severe mental illness with insufficient care. Physical pain should be systematically explored and treated in this population. Bipolar disorders, antidepressant consumption and female gender may be targeted in priority. Age and psychotic symptomatology were found to influence self-reported pain in a marginal way.
C1 [Fond, G.; Tinland, A.; Boucekine, M.; Girard, V; Loubiere, S.; Boyer, L.; Auquier, P.] Aix Marseille Univ, Sch Med, EA 3279, CEReSS Hlth Serv Res & Qual Life Ctr, La Timone Med Campus, Marseille, France.
   [Tinland, A.; Girard, V] St Marguerite Univ Hosp, Dept Psychiat, Marseille, France.
   [Boucekine, M.; Loubiere, S.] AP HM, Serv Epidemiol & Econ Sante, Marseille, France.
C3 Aix-Marseille Universite; Aix-Marseille Universite; Assistance
   Publique-Hopitaux de Marseille; Aix-Marseille Universite; Assistance
   Publique-Hopitaux de Marseille
RP Fond, G (corresponding author), Aix Marseille Univ, EA 3279, Publ Hlth Chron Dis & Qual Life, Res Unit, F-13284 Marseille, France.
EM guillaume.fond@ap-hm.fr
RI Boyer, Laurent/E-5728-2016; Fond, Guillaume/D-7646-2011
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NR 43
TC 9
Z9 12
U1 0
U2 79
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0278-5846
EI 1878-4216
J9 PROG NEURO-PSYCHOPH
JI Prog. Neuro-Psychopharmacol. Biol. Psychiatry
PD JAN 10
PY 2019
VL 88
BP 175
EP 180
DI 10.1016/j.pnpbp.2018.07.021
PG 6
WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA GU8ZY
UT WOS:000445634300019
PM 30053572
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Fortin, CN
   Saed, GM
   Diamond, MP
AF Fortin, Chelsea N.
   Saed, Ghassan M.
   Diamond, Michael P.
TI Predisposing factors to post-operative adhesion development
SO HUMAN REPRODUCTION UPDATE
LA English
DT Article
DE post-operative adhesions; predisposing factors; hemostasis; fibrosis;
   hypoxia
ID PLASMINOGEN-ACTIVATOR INHIBITOR-1; ENCAPSULATING PERITONEAL SCLEROSIS;
   BETA-FIBRINOGEN GENE; MODERATE ALCOHOL-CONSUMPTION; MALIGNANT COLORECTAL
   DISEASE; CARDIOVASCULAR RISK-FACTOR; SMALL-BOWEL OBSTRUCTION;
   CORONARY-HEART-DISEASE; WOUND-HEALING PROBLEMS; VON-WILLEBRAND-FACTOR
AB Adhesion development is the most common sequelae of intra-abdominal and pelvic surgery and represents a significant, yet poorly understood, cause of morbidity among post-operative patients. It remains unclear, for example, exactly why adhesions form more frequently in certain tissues and/or patients, or at specific locations within them, as opposed to others. This review contributes to the growing knowledge pool by elucidating factors that potentially predispose to the development of adhesions. Given the strong correlation between a hypofibrinolytic state and adhesion formation, this review article will examine not only those factors that have been shown to directly predispose to adhesion development, but also those that are likely do so indirectly by means of altering the coagulation/fibrinolytic profile.
   A literature search was performed using the PubMed database for all relevant English language articles up to February 2014. All of the identified articles were reviewed with particular attention to predisposing factors to post-operative adhesion development. In addition, the reference lists of each article were reviewed to identify additional relevant articles.
   Various factors have been shown to directly increase the risk of post-operative adhesion development; namely, certain genetic polymorphisms in the interleukin-1 receptor antagonist, increased estrogen exposure, and endometriosis. In addition, numerous factors are known to increase the risk of fibrosis, therefore likely increasing the risk of adhesion development indirectly. These factors include genetic polymorphisms in plasminogen activator inhibitor-1 and thrombin-activatable fibrinolysis inhibitor, diabetes mellitus, metabolic syndrome, hyperglycemia, obesity, depression, binge alcohol consumption, anti-Parkinsonian medications, oral hormone therapy, pregnancy, and cancer.
   The literature reviewed in this paper will help to direct future research aimed at understanding the mechanisms that underlie the association of certain factors with adhesion development. This information will be crucial in the creation of adequate preventative and treatment strategies.
C1 [Fortin, Chelsea N.] Wayne State Univ, Sch Med, Detroit, MI 48201 USA.
   [Saed, Ghassan M.] Wayne State Univ, Sch Med, CS Mott Ctr Human Growth & Dev, Dept Obstet & Gynecol, Detroit, MI 48201 USA.
   [Diamond, Michael P.] Georgia Regents Univ, Dept Obstet & Gynecol, Med Coll Georgia, Augusta, GA 30912 USA.
C3 Wayne State University; Wayne State University; University System of
   Georgia; Augusta University
RP Fortin, CN (corresponding author), Wayne State Univ, Sch Med, Detroit, MI 48201 USA.
EM cfortin@med.wayne.edu
OI Diamond, Michael/0000-0001-6353-4489; Saed, Ghassan/0000-0003-1098-7147
FU EMD Serono; AbbVie
FX M.P.D. serves on the Board of Directors for Advanced Reproductive Care
   and is a stockholder in the company. He is also a consultant for
   Actamax, Auxogyn, Teijin Pharmaceutical, and ZSX Medical, and has
   received grant support from EMD Serono and AbbVie. C.N.F. and G.M.S have
   nothing to declare.
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NR 236
TC 81
Z9 87
U1 4
U2 32
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1355-4786
EI 1460-2369
J9 HUM REPROD UPDATE
JI Hum. Reprod. Update
PD JUL-AUG
PY 2015
VL 21
IS 4
BP 536
EP 551
DI 10.1093/humupd/dmv021
PG 16
WC Obstetrics & Gynecology; Reproductive Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology; Reproductive Biology
GA CM2QE
UT WOS:000357525700007
PM 25935859
OA Bronze
DA 2025-06-11
ER

PT J
AU Zheng, ZH
   Yu, ZJ
   Xu, BY
   Zhou, Y
   Xing, YB
   Li, QS
   Tang, WL
   Peng, F
AF Zheng, Zhaohai
   Yu, Zhangjie
   Xu, Buyun
   Zhou, Yan
   Xing, Yangbo
   Li, Qingsong
   Tang, Weiliang
   Peng, Fang
TI Pretreatment with Shenmai Injection Protects against Coronary
   Microvascular Dysfunction
SO EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Article
ID CARDIAC SYNDROME-X; ENDOTHELIAL DYSFUNCTION; PATHWAY
AB Background. The clinical treatment of coronary microvascular dysfunction (CMD) is mainly based on conventional medicine, but the mechanism of the medicine is single and the efficacy is different. Shenmai injection (SMI) has a variety of ingredients, but the effect of SMI on CMD has not been studied. This study investigated the effect of SMI on CMD and its possible mechanism. Methods. The protective effect of SMI on CMD was evaluated in Sprague-Dawley (SD) rats and human umbilical vein endothelial cells (HUVECs). In vivo, forty-five male SD rats were randomly divided into control group (sham group), CMD group (model group), and SMI group (treatment group). Two weeks after SMI intervention, laurate was injected into the left ventricle of rats to construct a CMD model. Blood samples were collected to detect myocardial enzymes, oxidative stress, and inflammatory factors, and the hearts of rats were extracted for histopathological staining and western blot detection. In vitro, a hydrogen peroxide-induced endothelial injury model was established in HUVECs. After pretreatment with SMI, cell viability, oxidative stress, vasodilative factors, and apoptosis were detected. Results. In vivo, pretreatment with SMI could effectively reduce the concentrations of lactate dehydrogenase (LDH), creatine kinase-MB (CK-MB), cardiac troponin I (cTnI), endothelin-1 (ET-1), tumor necrosis factor alpha (TNF-alpha), interleukin 6 (IL-6), and malondialdehyde (MDA) in the serum of rats. Meanwhile, the expression of bcl-2-associated X (Bax) and caspase-3 protein in the myocardium of rats was decreased in the SMI group. The levels of nitric oxide (NO) and superoxide dismutase (SOD) and the expression of B-cell lymphoma-2 (Bcl-2) were higher in the SMI group than in the CMD group. Pathological staining results showed that SMI could effectively reduce inflammatory infiltration and the formation of collagen fibers and microthrombus in the rat myocardium. In vitro, intervention with SMI could improve endothelial function in a dose-dependent manner as evidenced by increasing the activity of endothelial cells and the expression of NO, SOD, endothelial nitric oxide synthase (eNOS), and Bcl-2, while decreasing cell apoptosis and the levels of ET-1, MDA, Bax, and caspase-3. Conclusions. Pretreatment with SMI could improve CMD by alleviating oxidative stress, inflammatory response, and apoptosis and then improving vascular endothelial function and microvascular structure.
C1 [Zheng, Zhaohai; Yu, Zhangjie; Xu, Buyun; Zhou, Yan; Xing, Yangbo; Tang, Weiliang; Peng, Fang] Zhejiang Univ, Shaoxing Peoples Hosp, Shaoxing Hosp, Dept Cardiol,Sch Med, Shaoxing 312000, Zhejiang, Peoples R China.
   [Zheng, Zhaohai] Zhejiang Univ, Sch Med, Hangzhou 310000, Zhejiang, Peoples R China.
   [Yu, Zhangjie] Shaoxing Univ, Sch Med, Shaoxing 312000, Zhejiang, Peoples R China.
   [Li, Qingsong] Awati Cty Peoples Hosp, Dept Cardiol, 1 North Jiefang Rd, Xiangyang 843000, Xinjiang, Peoples R China.
C3 Zhejiang University; Zhejiang University; Shaoxing University
RP Tang, WL; Peng, F (corresponding author), Zhejiang Univ, Shaoxing Peoples Hosp, Shaoxing Hosp, Dept Cardiol,Sch Med, Shaoxing 312000, Zhejiang, Peoples R China.
EM 21918231@zju.edu.cn; yzj451@foxmail.com; xbyzju@126.com;
   zhouzhou331301@sina.com; xyb1845@163.com; 269188058@qq.com;
   twl-sxyz@163.com; sxrmyypf@126.com
RI LI, QS/IED-7767-2023
OI Tang, Weiliang/0000-0002-6809-5056; Peng, Fang/0000-0002-3826-5632
FU Zhejiang Province Traditional Chinese Medicine Scientific Research Fund
   Project [2021ZB308]; Shaoxing Science and Technology Plan (medical and
   health) Project [2018C30067]; Hospital Youth Fund Project of Shaoxing
   People's Hospital [2018YB03]
FX THis study was supported by funds from the Zhejiang Province Traditional
   Chinese Medicine Scientific Research Fund Project (grant no. 2021ZB308),
   Shaoxing Science and Technology Plan (medical and health) Project (grant
   no. 2018C30067), and the Hospital Youth Fund Project of Shaoxing
   People's Hospital (grant no. 2018YB03).
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NR 32
TC 3
Z9 3
U1 0
U2 14
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1741-427X
EI 1741-4288
J9 EVID-BASED COMPL ALT
JI Evid.-based Complement Altern. Med.
PD JUN 9
PY 2022
VL 2022
AR 8630480
DI 10.1155/2022/8630480
PG 10
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA 2G9XI
UT WOS:000813953700001
PM 35722150
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Kalantar, MH
   Bayat, PD
   Khaligh, SG
   Soleimani, H
AF Kalantar, Mohammad Hassan
   Bayat, Parvin-Dokht
   Khaligh, Sahar Ghaffari
   Soleimani, Homa
TI The role of curcumin during pregnancy on the exposed fetuses' tissues of
   Wistar rats to electromagnetic field
SO ELECTROMAGNETIC BIOLOGY AND MEDICINE
LA English
DT Article
DE Curcumin; electromagnetic field; histopathological damage; pregnancy
   period
ID OXIDATIVE STRESS; KIDNEY; INFLAMMATION; METABOLISM; APOPTOSIS; PATHWAY;
   INJURY; DAMAGE
AB To investigate curcumin (CUR) as the protector against the harmful effects of low-frequency electromagnetic field(LF- EMF, 50 Hz) during pregnancy period, 5 males and 15 females of Wistar rat mated and vaginal plaques were observed. Then, the pregnant rats were divided into six groups. During pregnancy(21 days), the EMF group was exposed to EMF for 30 min/day, the CUR group received a single dose of 50 mg/kg/daily CUR intraperitoneal, the EMF+CUR group was injected CUR and exposed to EMF daily. The DMSO(dimethyl sulfoxide) group was injected solvent of CUR (DMSO) intraperitoneal with the same volume of CUR solvent, the sham group was placed through the solenoid in the same conditions as the first group without exposure and the control group was kept in their cage in normal condition. After four weeks, babies born were divided according to the mother groups and sacrificed. Then, the three tissues injuries were investigated. EMF exposure led to an increase in outstanding necrotic areas in hippocampal tissue, an increase in the amount of hyperemia(p = 0.017) and necrotic(p = 0.005) in kidneys, and degeneration in liver tissue(p = 0.007) in the EMF group compared with EMF+CUR groups. A single dose of CUR daily during pregnancy can protect these tissues from injuries caused by LF-EMF exposure in rat fetuses.
   Electromagnetic fields (EMFs) are able to penetrate and be absorbed by the body. The researchers showed that these radiations might be harmful and lead to cancers, cardiovascular diseases, mental disorders, and fetal abnormalities. Curcumin as an active component in turmeric has anti-inflammatory, antioxidant and anti-hyperlipidemia properties. It can protect the body against diseases such as arthritis, anxiety, and metabolic syndrome. This study examined the effects of curcumin as the protector against the harmful effects of EMF (50Hz) during pregnancy period. So the pregnant rats were divided into six groups. During pregnancy, a group was exposed to EMF for 30 min/day, the second group was injected a dose of curcumin 50mg/kg/daily, the third group was injected curcumin and exposed to EMF daily. The fourth group was injected a curcumin solvent dose, the sham group was placed through the field generator in the same conditions as the first group without exposure and the control group was kept in their cage in normal condition. After four weeks, babies born were divided according to the mother groups and sacrificed. Then, the liver, kidney, and hippocampal tissues were investigated. EMF exposure led to an outstanding increase in necrotic areas in hippocampal tissue, a notable increase in the amount of hyperemia and necrosis in kidneys, and degeneration in liver tissue(p=0.007) in the EMF group compared with the third group that was exposed to EMF and received curcumin. A single dose of curcumin daily during pregnancy can protect these tissues from injuries caused by EMF(50Hz) exposure in rat fetuses.
C1 [Kalantar, Mohammad Hassan] Arak Univ Med Sci, Student Res Comm, Sch Med, Arak, Iran.
   [Bayat, Parvin-Dokht] Arak Univ Med Sci, Sch Med, Dept Anat, Arak, Iran.
   [Khaligh, Sahar Ghaffari] Semnan Univ, Fac Vet Med, Dept Pathobiol, Semnan, Iran.
   [Soleimani, Homa] Arak Univ Med Sci, Fac Para Med, Dept Med Phys, Arak, Iran.
   [Soleimani, Homa] Arak Univ Med Sci, Sch Med, Dept Med Phys & Physiol, Arak, Iran.
   [Soleimani, Homa] Arak Univ Med Sci, Fac Para Med, Dept Med Phys, Basij Ave Sardasht, Arak 848176941, Markazi, Iran.
C3 Semnan University
RP Soleimani, H (corresponding author), Arak Univ Med Sci, Fac Para Med, Dept Med Phys, Basij Ave Sardasht, Arak 848176941, Markazi, Iran.
EM dr.hsoleimani@arakmu.ac.ir
RI Ghaffari Khaligh, Sahar/AAY-3663-2021
OI kalantar Neyestanaki, Mohammad Hassan/0000-0001-9273-7584; Ghaffari
   Khaligh, Sahar/0000-0002-1622-1903; Soleimani, Homa/0000-0001-6944-2462
FU specific grant; Research Council of Arak University of Medical Sciences
FX The authors are grateful to the financial support of the Research
   Council of Arak University of Medical Sciences and Dr. Farideh Jalali
   Mashayekhi the member of the Biochemistry Department of Arak University
   of Medical Sciences who have sincerely cooperated in all stages of this
   study.
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NR 44
TC 0
Z9 0
U1 8
U2 11
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1536-8378
EI 1536-8386
J9 ELECTROMAGN BIOL MED
JI Electromagn. Biol. Med.
PD APR 2
PY 2024
VL 43
IS 1-2
BP 71
EP 80
DI 10.1080/15368378.2024.2315214
EA FEB 2024
PG 10
WC Biology; Biophysics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics; Biophysics
GA OQ1P8
UT WOS:001164000800001
PM 38366892
DA 2025-06-11
ER

PT J
AU Nagata, C
   Tamura, T
   Wada, K
   Konishi, K
   Goto, Y
   Nagao, Y
   Ishihara, K
   Yamamoto, S
AF Nagata, Chisato
   Tamura, Takashi
   Wada, Keiko
   Konishi, Kie
   Goto, Yuko
   Nagao, Yasuko
   Ishihara, Kazuhiro
   Yamamoto, Satoru
TI Sleep duration, nightshift work, and the timing of meals and urinary
   levels of 8-isoprostane and 6-sulfatoxymelatonin in Japanese women
SO CHRONOBIOLOGY INTERNATIONAL
LA English
DT Article
DE 6-sulfatoxymelatonin; 8-isoprostane; circadian; meal timing; nightshift;
   sleep
ID INSULIN SENSITIVITY; OXIDATIVE STRESS; METABOLIC SYNDROME;
   CIRCADIAN-RHYTHMS; EATING SYNDROME; LIPID PROFILES; ENERGY-INTAKE;
   NEUROENDOCRINE; FREQUENCY; MELATONIN
AB It has been hypothesized that disruption of circadian rhythms affects human health. Shift work and sleep deprivation are thought to disrupt the normal light-dark cycle, although the disruption due to shiftwork may be dependent on sleep deprivation. Both conditions have been suggested to be associated with an increased risk of cardiometabolic disorders. Non-photic environmental factors, such as the timing of eating, are also thought to regulate circadian rhythm and thus, may have effects on health, but the evidence from human studies is scarce. Oxidative stress is a risk factor of cardiometabolic disorders. Some laboratory studies suggest an involvement of circadian clock genes in the regulation of the redox system. The present study aimed to examine the association of sleeping habits, nightshift work, and the timing of meals with urinary levels of 8-isoprostane, a marker of oxidative stress, and 6-sulfatoxymelatonin, the principal metabolite of melatonin. Study subjects were 542 women who had previously attended a breast cancer mass screening in a community in Japan. Information on bedtimes and wake-up times, history of nightshift work, and the timing of meals was obtained by a self-administered questionnaire. The 8-isoprostane and 6-sulfatoxymelatonin were measured using the first morning void of urine and expressed per mg of creatinine. The geometric mean of 8-isoprostane levels was 12.1% higher in women with <= 6 hours of sleep than that in those with > 8 hours of sleep on weekdays, and longer sleep duration on weekdays was significantly associated with lower urinary levels of 8-isoprostane after controlling for covariates (p for trend = 0.04). Women who were currently working the nightshift had a 33.3% higher geometric mean of 8-isoprostane levels than those who were not working nightshift (p = 0.03). Urinary 6-sulfatoxymelatonin levels were unrelated to sleep habits or nightshift work. Women who ate breakfast at irregular times had a 19.8% higher geometric mean of 8-isoprostane levels than those who ate breakfast at a regular time or who did not eat (p = 0.02). Women who ate nighttime snacks at irregular times had a 16.2% higher geometric mean of 8-isoprostane levels than those who did not eat nighttime snacks or who ate nighttime snacks at a regular time (p = 0.003). Among women who ate dinner at a regular time, earlier times for dinner were associated with higher 8-isoprostane and 6-sulfatoxymelatonin levels (p values for trends were 0.01 and 0.02, respectively). However, the times of dinner and nighttime snack are overlapping, and the time of last meal of the day was not associated with 8-isoprostane and 6-sulfatoxymelatonin levels. The time of breakfast or lunch was not associated with these biomarkers among women who ate the meal at regular times. Disturbing the rhythmicity of daily life may be associated with oxidative stress.
C1 [Nagata, Chisato; Tamura, Takashi; Wada, Keiko; Konishi, Kie; Goto, Yuko] Gifu Univ, Grad Sch Med, Dept Epidemiol & Prevent Med, Gifu, Japan.
   [Nagao, Yasuko; Ishihara, Kazuhiro; Yamamoto, Satoru] Gihoku Kousei Hosp, Gifu, Japan.
C3 Gifu University
RP Nagata, C (corresponding author), Gifu Univ, Grad Sch Med, Dept Epidemiol & Prevent Med, Gifu, Japan.
EM chisato@gifu-u.ac.jp
FU Ministry of Education, Science, Sports, Culture and Technology of Japan
FX This study was supported by Grants-in-Aid for Scientific Research from
   the Ministry of Education, Science, Sports, Culture and Technology of
   Japan.
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NR 43
TC 31
Z9 33
U1 0
U2 13
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 0742-0528
EI 1525-6073
J9 CHRONOBIOL INT
JI Chronobiol. Int.
PY 2017
VL 34
IS 9
BP 1187
EP 1196
DI 10.1080/07420528.2017.1355313
PG 10
WC Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics; Physiology
GA FQ4XG
UT WOS:000418361300004
PM 28933565
DA 2025-06-11
ER

PT S
AU Klinge, CM
   Clark, BJ
   Prough, RA
AF Klinge, Carolyn M.
   Clark, Barbara J.
   Prough, Russell A.
BE Litwack, G
TI Dehydroepiandrosterone Research: Past, Current, and Future
SO DEHYDROEPIANDROSTERONE
SE Vitamins and Hormones
LA English
DT Review; Book Chapter
ID DIMINISHED OVARIAN RESERVE; SEX STEROIDS; PEROXISOMAL ENZYMES; ANDROGEN
   RECEPTOR; BREAST-CANCER; DHEA SULFATE; IN-VIVO; WOMEN; SUPPLEMENTATION;
   MEN
AB The discovery of "oestrus-producing" hormones was a major research breakthrough in biochemistry and pharmacology during the early part of the 20th century. The elucidation of the molecular weight and chemical structure of major oxidative metabolites of dehydroepiandrosterone (DHEA) led to the award of the Nobel Prize in 1939 to Adolf Frederick Johann Butenandt and Leopold Ruzicka. Considered a bulk androgen in the circulation, DHEA and its sulfated metabolite DHEA-S can be taken up by most tissues where the sterols are metabolized to active androgenic and estrogenic compounds needed for growth and development. Butenandt's interactions with the German pharmaceutical company Schering led to production of gram quantities of these steroids and other chemically modified compounds of this class. Sharing chemical expertise allowed Butenandt's laboratory at the Kaiser Wilhelm Institute to isolate and synthesize many steroid compounds in the elucidation of the pathway leading from cholesterol to testosterone and estrogen derivatives. As a major pharmaceutical company worldwide, Schering AG sought these new biological sterols as pharmacological agents for endocrine-related diseases, and the European medical community tested these compounds in women for conditions such as postmenopausal depression, and in men for increasing muscle mass. Since it was noted that circulating DHEA-S levels decline as a function of age, experimental pathology experiments in animals were performed to determine how DHEA may protect against cancer, diabetes, aging, obesity, immune function, bone density, depression, adrenal insufficiency, inflammatory bowel disease, diminished sexual function/libido, AIDS/HIV, chronic obstructive pulmonary disease, coronary artery disease, chronic fatigue syndrome, and metabolic syndrome. While the mechanisms by which DHEA ameliorates these conditions in animal models have been elusive to define, even less is known about its role in human disease, other than as a precursor to other sterols, e.g., testosterone and estradiol. Our groups have shown that DHEA and many of its oxidative metabolites serve as a low-affinity ligands for hepatic nuclear receptors, such as the pregnane X receptor, the constitutive androstane receptor, and estrogen receptors alpha/beta (ER alpha/ER beta) as well as G protein-coupled ER (GPER1). This chapter highlights the founding research on DHEA from a historical perspective, provides an overview of DHEA biosynthesis and metabolism, briefly summarizes the early work on the beneficial effects attributed to DHEA in animals, and summarizes the human trials addressing the action of DHEA as a therapeutic agent. In general, most human studies involve weak correlations of circulating levels of DHEA and disease outcomes. Some support for DHEA as a therapeutic compound has been demonstrated for postmenopausal women, in vitro fertilization, and several autoimmune disorders, and adverse health effects, such as, acne, embryo virilization during pregnancy, and possible endocrine-dependent cancers.
C1 [Klinge, Carolyn M.; Clark, Barbara J.; Prough, Russell A.] Univ Louisville, Sch Med, Dept Biochem & Mol Genet, Ctr Genet & Mol Med, Louisville, KY 40292 USA.
C3 University of Louisville
RP Prough, RA (corresponding author), Univ Louisville, Sch Med, Dept Biochem & Mol Genet, Ctr Genet & Mol Med, Louisville, KY 40292 USA.
EM russ.prough@louisville.edu
RI Russell A, Prough/AAH-5907-2020
OI Prough, Russell/0000-0001-8901-8490; Clark, Barbara/0000-0003-1558-1904
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NR 101
TC 70
Z9 75
U1 2
U2 23
PU ELSEVIER ACADEMIC PRESS INC
PI SAN DIEGO
PA 525 B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0083-6729
BN 978-0-12-814361-2
J9 VITAM HORM
JI Vitam. Horm.
PY 2018
VL 108
BP 1
EP 28
DI 10.1016/bs.vh.2018.02.002
PG 28
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Book Citation Index – Science (BKCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA BL5NS
UT WOS:000452381500002
PM 30029723
DA 2025-06-11
ER

PT J
AU Almeida, GPL
   Trombetta, IC
   Cepeda, FX
   Hatanaka, E
   Curi, R
   Mostarda, C
   Irigoyen, MC
   Barreto, JAS
   Krieger, EM
   Consolim-Colombo, FM
AF Almeida, Germana P. L.
   Trombetta, Ivani C.
   Cepeda, Felipe X.
   Hatanaka, Elaine
   Curi, Rui
   Mostarda, Cristiano
   Irigoyen, Maria C.
   Barreto-Filho, Jose A. S.
   Krieger, Eduardo M.
   Consolim-Colombo, Fernanda M.
TI The Role of Acute Intermittent Hypoxia in Neutrophil-Generated
   Superoxide, Sympathovagal Balance, and Vascular Functionin Healthy
   Subjects
SO FRONTIERS IN PHYSIOLOGY
LA English
DT Article
DE oxidative stress; sympathovagal balance; chemoreflex; O-2 saturation;
   peripheral vascular resistance; blood pressure
ID OBSTRUCTIVE SLEEP-APNEA; POSITIVE AIRWAY PRESSURE; OXIDATIVE STRESS;
   BLOOD-PRESSURE; METABOLIC SYNDROME; RAT; ATHEROSCLEROSIS; ELEVATION;
   HUMANS; HYPERTENSION
AB Introduction: Recurrent hypoxia (HPX), a hallmark of the obstructive sleep apnea (OSA), impairs autonomic balance, and increases arterial blood pressure (BP). Oxidative stress is one of the mechanisms involved in these alterations. The cumulative effect of acute intermittent HPX and the chronicity may determine whether the response crosses the threshold from having protective value to pathology. However, the impact of acute intermittent HPXreoxygenation on markers of oxidative stress in healthy individuals remains to be fully understood.
   Objective: To analyze the effects of the acute intermittent HPX on the generation of neutrophil-derived superoxide, sympathovagal balance, and vascular function in healthy subjects.
   Methods: We applied six cycles of intermittent HPX (10% O-2 and 90% N2) for 5 min followed by 2 min of room-air in 15 healthy volunteers (34 +/- 2 years; 22.3 +/- 0.46 kg/m(2)), without OSA (polysomnography), during wakefulness. During the experimental protocol, we recorded O-2 saturation, end-tidal CO2, heart rate (HR), systolic, and diastolic BP, cardiac output (CO) and peripheral resistance (PR). Cardiac sympathovagal balance was determined by HR variability analysis (low frequency and high frequency bands, LF/HF). Superoxide generation in polymorphonuclear neutrophil cells were established using relative luminescence units (PMNs RLU) at baseline (pre-HPX) and immediately after hypoxia induction (post-HPX6). we recorded O-2 saturation, end-tidal CO2, heart rate (HR), systolic, and diastolic BP, cardiac output (CO) and peripheral resistance (PR). Cardiac sympathovagal balance was determined by HR variability analysis (low frequency and high frequency bands, LF/HF). Superoxide generation in polymorphonuclear neutrophil cells were established using relative luminescence units (PMNs RLU) at baseline (pre-HPX) and immediately after hypoxia induction (post-HPX6).
   Results: The studied subjects had normal levels of BP, plasma glucose, lipid profile, and inflammatory marker (C-reactive protein). Acute intermittent HPX increased HR, systolic BP, CO, and decreased PR. Additionally, acute intermittent HPX increased PMNs RLU, measured post-HPX6 (470 +/- 50 vs. 741 +/- 135, P < 0.05). We found a similar increase in LF/HF post-HPX6 (0.91 +/- 0.11 vs. 2.85 +/- 0.40, P < 0.05). PR was diminished from pre-HPX to post-HPX6 (1.0 +/- 0.03 vs. 0.85 +/- 0.06, P < 0.05). Further analysis showed significant association between O-2 saturation and PMNs RLU (R = -0.62, P = 0.02), and with LF/HF (R = -0.79, P = 0.02) post-HPX6. In addition, an association was found between PMNs RLU and PR post-HPX6 (R = 0.58, P = 0.04).
   Conclusion: Acute exposure to intermittent HPX not only increased superoxide generation in neutrophils, but also impaired cardiac sympathovagal balance in healthy subjects. These data reinforce the role of intermittent HPX in superoxide generation on neutrophils, which may lead to an impairment in peripheral vascular resistance.
C1 [Almeida, Germana P. L.; Cepeda, Felipe X.; Irigoyen, Maria C.; Krieger, Eduardo M.; Consolim-Colombo, Fernanda M.] Univ Sao Paulo, Hosp Clin, Fac Med, Heart Inst, Sao Paulo, Brazil.
   [Almeida, Germana P. L.] Univ Fed Ceara, Dept Clin Med, Ceara, Brazil.
   [Trombetta, Ivani C.; Consolim-Colombo, Fernanda M.] Univ Nove Julho, Uninove, Grad Program Med, Sao Paulo, Brazil.
   [Hatanaka, Elaine] Univ Cruzeiro Sul, Inst Ciencias Atividade Fis & Esportes, Sao Paulo, Brazil.
   [Curi, Rui] Univ Sao Paulo, Inst Biomed Sci, Dept Physiol & Biophys, Sao Paulo, Brazil.
   [Mostarda, Cristiano] Univ Fed Maranhao, Program Posgrad Saude Adulto & Crianca, Maranhao, Brazil.
   [Barreto-Filho, Jose A. S.] Univ Fed Sergipe, Div Cardiol, Sergipe, Brazil.
C3 Universidade de Sao Paulo; Universidade Federal do Ceara; Universidade
   Nove de Julho; Universidade Cruzeiro do Sul; Universidade de Sao Paulo;
   Institute Biomed Science, University Sao Paulo; Universidade Federal do
   Maranhao; Universidade Federal de Sergipe
RP Consolim-Colombo, FM (corresponding author), Univ Sao Paulo, Hosp Clin, Fac Med, Heart Inst, Sao Paulo, Brazil.; Consolim-Colombo, FM (corresponding author), Univ Nove Julho, Uninove, Grad Program Med, Sao Paulo, Brazil.
EM hipfernanda@incor.usp.br
RI Curi, Rui/AAT-7970-2021; Krieger, Jose/C-3117-2011; Hatanaka,
   Elaine/D-6337-2012; Colombo, Fernanda/C-6911-2018; Trombetta,
   Ivani/G-5839-2012; Mostarda, Cristiano/AAG-4087-2019; Xerez Cepeda,
   Felipe/G-3340-2013; Irigoyen, maria Claudia/N-6880-2014
OI Hatanaka Dermargos, Elaine/0000-0002-9716-1163; CURI,
   RUI/0000-0001-5095-9154; Colombo, Fernanda/0000-0003-3220-019X; Xerez
   Cepeda, Felipe/0000-0003-1544-3499; Mostarda, Cristiano
   Teixeira/0000-0002-1305-1697; Irigoyen, maria
   Claudia/0000-0003-2097-3662
FU Fundacao Zerbini; Fundacao de Amparo a Pesquisa do Estado de Sao Paulo
   (FAPESP) [04/0222]; FAPESP [2015/17533-6, 2016/16831-7, 2010/02963-2];
   CNPq [303853/2015-3, 442374/2014-3]; Guggenheim Foundation; FAPEMA
   [UNIVERSAL-00358/15]
FX This was not an industry-supported study. The work was performed at the
   Heart Institute (InCor), University of Sao Paulo Medical School, Sao
   Paulo, Brazil and was supported by Fundacao Zerbini. This study was
   supported by Fundacao de Amparo a Pesquisa do Estado de Sao Paulo
   (FAPESP # 04/0222), FXC (FAPESP#2015/17533-6 and #2016/16831-7), RC
   (FAPESP 2010/02963-2, CNPq 303853/2015-3 and Guggenheim Foundation), CM
   (CNPq 442374/2014-3 and FAPEMA UNIVERSAL-00358/15 - Edital 40/2014).
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NR 39
TC 5
Z9 5
U1 1
U2 11
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA PO BOX 110, EPFL INNOVATION PARK, BUILDING I, LAUSANNE, 1015,
   SWITZERLAND
SN 1664-042X
J9 FRONT PHYSIOL
JI Front. Physiol.
PD JAN 23
PY 2017
VL 8
AR 4
DI 10.3389/fphys.2017.00004
PG 8
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA EI3MV
UT WOS:000392396000001
PM 28167915
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Waziry, R
   Jawad, M
   Ballout, RA
   Al Akel, M
   Akl, EA
AF Waziry, Reem
   Jawad, Mohammed
   Ballout, Rami A.
   Al Akel, Mohammad
   Akl, Elie A.
TI The effects of waterpipe tobacco smoking on health outcomes: an updated
   systematic review and meta-analysis
SO INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
LA English
DT Article
DE Waterpipe tobacco smoking; health effects; systematic review
ID SQUAMOUS-CELL CARCINOMA; CIGARETTE-SMOKING; PIPE SMOKING; RISK-FACTORS;
   LUNG-CANCER; CARDIOVASCULAR-DISEASE; PROSTATE-CANCER; BLADDER-CANCER;
   HOOKAH SMOKING; ORAL-CANCER
AB Background and aims: A systematic review conducted in 2008 found significant associations between waterpipe tobacco smoking and lung cancer, respiratory disease, periodontal disease and low birthweight. Since then, a number of relevant studies have been published. The objective of this study was to update the systematic review on the effects of waterpipe tobacco smoking on health outcomes.
   Methods: In May 2015 we electronically searched the following databases with no date restrictions: MEDLINE, EMBASE and the ISI Web of Science using a detailed search strategy with no language restrictions. We also screened the references' lists of the included studies. We included cohort, case-control and cross-sectional studies, and excluded case reports, conference abstracts, editorials and reviews. We excluded studies not conducted in humans, assessing physiological outcomes, not distinguishing waterpipe tobacco smoking from other forms of smoking or not reporting association measures. We assessed risk of bias for each included study and conducted meta-analyses for each of the outcomes of interest.
   Results: We identified 50 eligible studies. We found that waterpipe tobacco smoking was significantly associated with: respiratory diseases [COPD; odds ratio (OR) = 3.18, 95% confidence interval CI = 1.25, 8.08; bronchitis OR = 2.37, 95% CI = 1.49, 3.77; passive waterpipe smoking and wheeze OR) = 1.97, 95% CI = 1.28, 3.04]; oral cancer OR = 4.17, 95% CI = 2.53, 6.89; lung cancer OR = 2.12, 95% CI = 1.32, 3.42; low birthweight (OR = 2.39, 95% CI = 1.32, 4.32); metabolic syndrome (OR 1.63-1.95, 95% CI = 1.25, 2.45); cardiovascular disease (OR = 1.67, 95% CI = 1.25, 2.24); and mental health (OR 1.30-2.4, 95% CI = 1.20, 2.80). Waterpipe tobacco smoking was not significantly associated with: oesophageal cancer (OR = 4.14, 95% CI = 0.93, 18.46); worse quality of life scores [ standardized mean difference (SMD) = = 0.16, 95% CI = = 0.66, 0.34]; gastric carcinoma (OR = 2.16, 95% CI = 0.72, 6.47); bladder cancer (OR = 1.25, 95% CI = 0.99, 1.57); prostate cancer (OR = 7.00, 95% CI = 0.90, 56.90); hepatitis C infection (OR = 0.98, 95% 0.80, 1.21); periodontal disease (OR = 3.00, 5.00); gastro-oesophageal reflux disease (OR = 1.25, 95% CI = 1.01, 1.56); nasopharyngeal carcinoma (OR = 0.49, 95% CI = 0.20, 1.23); bladder cancer (OR = 1.25, 95% CI = 0.99, 1.57); infertility (OR = 2.50, 95% CI = 1.00, 6.30); and mortality (OR = 1.15, 95% CI = 0.93, 1.43).
   Conclusions: There is accumulating evidence about the association of waterpipe tobacco smoking with a growing number of health outcomes.
C1 [Waziry, Reem; Al Akel, Mohammad] Amer Univ Beirut, Fac Hlth Sci, Beirut, Lebanon.
   [Waziry, Reem] Univ New South Wales, Kirby Inst, Sydney, NSW, Australia.
   [Jawad, Mohammed] Imperial Coll London, Dept Primary Care & Publ Hlth, London, England.
   [Jawad, Mohammed] Univ Southampton, Acad Dept Primary Care & Populat Sci, Southampton, Hants, England.
   [Ballout, Rami A.] Amer Univ Beirut, Fac Med, Beirut, Lebanon.
   [Akl, Elie A.] Amer Univ Beirut, Dept Internal Med, Beirut, Lebanon.
   [Akl, Elie A.] McMaster Univ, Dept Clin Epidemiol & Biostat, Hamilton, ON, Canada.
C3 American University of Beirut; University of New South Wales Sydney;
   Kirby Institute; Imperial College London; University of Southampton;
   American University of Beirut; American University of Beirut; McMaster
   University
RP Akl, EA (corresponding author), Amer Univ Beirut, Med Ctr, Dept Internal Med, POB 11-0236, Beirut 11072020, Lebanon.
EM ea32@aub.edu.lb
RI Jawad, Mohammed/I-6919-2019; Akl, Elie/K-5269-2019
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NR 86
TC 234
Z9 242
U1 3
U2 91
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0300-5771
EI 1464-3685
J9 INT J EPIDEMIOL
JI Int. J. Epidemiol.
PD FEB
PY 2017
VL 46
IS 1
BP 32
EP 43
DI 10.1093/ije/dyw021
PG 12
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA EW7VB
UT WOS:000402724100014
PM 27075769
OA Bronze, Green Submitted
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Undén, AL
   Elofsson, S
   Brismar, K
AF Undén, AL
   Elofsson, S
   Brismar, K
TI Gender differences in the relation of insulin-like growth factor binding
   protein-1 to cardiovascular risk factors:: a population-based study
SO CLINICAL ENDOCRINOLOGY
LA English
DT Article
ID DEPENDENT DIABETES-MELLITUS; MIDDLE-AGED MEN; TOTAL IGF-I;
   SERUM-INSULIN; HORMONE-SECRETION; MYOCARDIAL-INFARCTION; PREMATURE
   MORTALITY; ELDERLY POPULATION; CIRCULATING LEVELS; GLUCOSE-TOLERANCE
AB Objective A possible involvement of insulin-like growth factor-I (IGF-I) and its binding protein IGFBP-1 in the pathogenesis of cardiovascular disorder has been suggested. However, few publications have addressed the gender differences in cardiovascular risk factors in relation to the IGF/IGFBP system. The aim of the present study was to study gender differences in the relationship between fasting serum levels of IGFBP-1 and cardiovascular risk factors in a normal population of men and women.
   Design Cross-sectional study.
   Patients A normal population of 273 men and women aged 20-74 years.
   Measurements A medical examination was performed and blood drawn in the morning after subjects had been fasting overnight. Before the examination, they were asked to fill out a questionnaire concerning lifestyle and psychosocial factors.
   Results Fasting IGFBP-1 was lower in men than in women and was positively correlated to age in men but not in women. The men had in general a more disadvantageous cardiovascular risk profile than women, with several indicators of the metabolic syndrome: higher blood pressure and higher serum levels of total cholesterol, triglycerides, low density lipoprotein cholesterol (LDL-C), plasma-glucose and insulin, as well as lower IGFBP-1. Women had lower physical activity, lower consumption of alcohol, and lower values on indicators of psychosocial and mental health but had a healthier diet. Our findings indicate that low circulating levels of IGFBP-1 are associated with the well-known risk factors of cardiovascular disease; however, the association showed a different pattern for men and women. In men we found a negative association with body mass index (BMI), insulin resistance and diastolic blood pressure, and a positive association with SHBG, cortisol and testosterone. For women low IGFBP-1 appears in negative associations with BMI, waist-hip ratio (WHR), insulin resistance and testosterone, and in positive associations with SHBG and cortisol. Significant gender differences in the correlation with IGFBP-1 are seen for testosterone, cortisol, SHBG, WHR and oestradiol. For HDL-C and diastolic blood pressure the gender difference in correlation was at the limit of significance (P < 0.10).
   Conclusion Low circulating levels of IGFBP-1 are associated with the well-known risk factors of cardiovascular disease; however, the association showed a different pattern for men and women. The most marked gender differences in the correlation with IGFBP-1 are seen for testosterone, cortisol, SHBG, WHR, oestradiol, HDL-C and diastolic blood pressure. Our study emphasizes the importance of separate analyses for men and women. The results presented are a step towards gaining a better understanding of the gender differences in cardiovascular disease and in the regulation of IGFBP-1, though further prospective studies are needed.
C1 Ctr Family Med Stockholm, SE-14183 Huddinge, Sweden.
   Univ Stockholm, Dept Social Work, S-10691 Stockholm, Sweden.
   Karolinska Inst, Dept Mol Med, Endocrine & Diabet Unit, Stockholm, Sweden.
C3 Stockholm University; Karolinska Institutet
RP Undén, AL (corresponding author), Ctr Family Med Stockholm, Alfred Nobels Alle 12, SE-14183 Huddinge, Sweden.
EM anna-lena.unden@klinvet.ki.se
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NR 72
TC 47
Z9 54
U1 0
U2 2
PU BLACKWELL PUBLISHING
PI OXFORD
PA 9600 GARSINGTON RD, OXFORD OX4 2DG, OXON, ENGLAND
SN 0300-0664
J9 CLIN ENDOCRINOL
JI Clin. Endocrinol.
PD JUL
PY 2005
VL 63
IS 1
BP 94
EP 102
DI 10.1111/j.1365-2265.2005.02306.x
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 937GO
UT WOS:000229912800015
PM 15963068
DA 2025-06-11
ER

PT J
AU Chan, JCN
   Sui, Y
   Oldenburg, B
   Zhang, YY
   Chung, HHY
   Goggins, W
   Au, SM
   Brown, N
   Ozaki, R
   Wong, RYM
   Ko, GTC
   Fisher, E
AF Chan, Juliana C. N.
   Sui, Yi
   Oldenburg, Brian
   Zhang, Yuying
   Chung, Harriet H. Y.
   Goggins, William
   Au, Shimen
   Brown, Nicola
   Ozaki, Risa
   Wong, Rebecca Y. M.
   Ko, Gary T. C.
   Fisher, Ed
CA JADE & PEARL Project Team
TI Effects of Telephone-Based Peer Support in Patients With Type 2 Diabetes
   Mellitus Receiving Integrated Care A Randomized Clinical Trial
SO JAMA INTERNAL MEDICINE
LA English
DT Article
ID EVALUATION JADE PROGRAM; DISEASE RISK SCORE; SELF-MANAGEMENT; GLYCEMIC
   CONTROL; HEALTH; VALIDATION; HOSPITALIZATION; INTERVENTION; IMPROVEMENT;
   DEPRESSION
AB IMPORTANCE In type 2 diabetes mellitus (T2DM), team management using protocols with regular feedback improves clinical outcomes, although suboptimal self-management and psychological distress remain significant challenges.
   OBJECTIVE To investigate if frequent contacts through a telephone-based peer support program (Peer Support, Empowerment, and Remote Communication Linked by Information Technology [PEARL]) would improve cardiometabolic risk and health outcomes by enhancing psychological well-being and self-care in patients receiving integrated care implemented through a web-based multicomponent quality improvement program (JADE [Joint Asia Diabetes Evaluation]).
   DESIGN, SETTING, AND PARTICIPANTS Between 2009 and 2010, 628 of 2766 Hong Kong Chinese patients with T2DM from 3 publicly funded hospital-based diabetes centers were randomized to the JADE + PEARL (n = 312) or JADE (n = 316) groups, with comprehensive assessment at 0 and 12 months.
   INTERVENTIONS Thirty-three motivated patients with well-controlled T2DM received 32 hours of training (four 8-hour workshops) to become peer supporters, with 10 patients assigned to each. Peer supporters called their peers at least 12 times, guided by a checklist.
   MAIN OUTCOMES AND MEASURES Changes in hemoglobin A(1c) (HbA(1c)) level (primary), proportions of patients with attained treatment targets (HbA(1c) <7%; blood pressure <130/80 mm Hg; low-density lipoprotein cholesterol <2.6 mmol/L [to convert to milligrams per deciliter, divide by 0.0256]) (secondary), and other health outcomes at month 12.
   RESULTS Both groups had similar baseline characteristics (mean [SD] age, 54.7 [9.3] years; 57% men; disease duration, 9.4 [7.7] years; HbA(1c) level, 8.2%[1.6%]; systolic blood pressure, 136 [19] mmHg; low-density lipoprotein cholesterol level, 2.89 [0.82] mmol/L; 17.4% cardiovascular-renal complications; and 34.9% insulin treated). After a mean (SD) follow-up period of 414 (55) days, 5 patients had died, 144 had at least 1 hospitalization, and 586 had repeated comprehensive assessments. On intention-to-treat analysis, both groups had similar reductions in HbA(1c) (JADE + PEARL, 0.30% [95% CI, 0.12%-0.47%], vs JADE, 0.29% [95% CI, 0.12%-0.47%] [P = .97]) and improvements in treatment targets and psychological-behavioral measures. In the JADE + PEARL group, 90% of patients maintained contacts with their peer supporters, with a median of 20 calls per patient. Most of the discussion items were related to self-management.
   CONCLUSIONS AND RELEVANCE In patients with T2DM receiving integrated care, peer support did not improve cardiometabolic risks or psychological well-being.
C1 [Chan, Juliana C. N.; Zhang, Yuying; Ozaki, Risa; Wong, Rebecca Y. M.; Ko, Gary T. C.] Chinese Univ Hong Kong, Prince Wales Hosp, Dept Med & Therapeut, Shatin, Hong Kong, Peoples R China.
   [Chan, Juliana C. N.; Chung, Harriet H. Y.; Ozaki, Risa] Chinese Univ Hong Kong, Prince Wales Hosp, Hong Kong Inst Diabet & Obes, Shatin, Hong Kong, Peoples R China.
   [Chan, Juliana C. N.; Sui, Yi; Brown, Nicola] Asia Diabet Fdn, Prince Wales Hosp, Shatin, Hong Kong, Peoples R China.
   [Oldenburg, Brian] Monash Univ, Melbourne, Vic 3004, Australia.
   [Goggins, William] Chinese Univ Hong Kong, Prince Wales Hosp, Jockey Club Sch Publ Hlth, Shatin, Hong Kong, Peoples R China.
   [Au, Shimen] Ruttonjee Hosp, Hong Kong, Hong Kong, Peoples R China.
   [Fisher, Ed] Univ N Carolina, Chapel Hill, NC 27514 USA.
C3 Chinese University of Hong Kong; Prince of Wales Hospital; Chinese
   University of Hong Kong; Prince of Wales Hospital; Chinese University of
   Hong Kong; Prince of Wales Hospital; Monash University; Chinese
   University of Hong Kong; Prince of Wales Hospital; University of North
   Carolina; University of North Carolina Chapel Hill
RP Chan, JCN (corresponding author), Chinese Univ Hong Kong, Prince Wales Hosp, Dept Med & Therapeut, Ninth Floor,Lui Che Woo Clin Sci Bldg, Shatin, Hong Kong, Peoples R China.
EM jchan@cuhk.edu.hk
RI Fisher, Edwin/M-5094-2019; Zhang, Yuying/JXL-5388-2024; Ma,
   Ronald/C-2788-2009; Chan, Juliana/B-7918-2016
OI Oldenburg, Brian/0000-0002-7712-5413; Fisher, Edwin/0000-0003-0234-7465;
   Ma, Ronald/0000-0002-1227-803X; Chan, Juliana/0000-0003-1325-1194
FU Asia Diabetes Foundation; Merck; American Academy of Family Physicians
   Foundation Peers for Progress Program; Eli Lilly and Company Foundation
FX This study was supported by the Asia Diabetes Foundation, partially
   funded by an educational grant by Merck, and the American Academy of
   Family Physicians Foundation Peers for Progress Program, funded by the
   Eli Lilly and Company Foundation.
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NR 39
TC 111
Z9 123
U1 0
U2 40
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 2168-6106
EI 2168-6114
J9 JAMA INTERN MED
JI JAMA Intern. Med.
PD JUN
PY 2014
VL 174
IS 6
BP 972
EP 981
DI 10.1001/jamainternmed.2014.655
PG 10
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA AI4OA
UT WOS:000336843500035
PM 24781960
DA 2025-06-11
ER

PT J
AU Holm, NJ
   Moller, T
   Adamsen, L
   Dalsgaard, LT
   Biering-Sorensen, F
   Schou, LH
AF Holm, Nicolaj Jersild
   Moller, Tom
   Adamsen, Lis
   Dalsgaard, Line Trine
   Biering-Sorensen, Fin
   Schou, Lone Helle
TI Health promotion and cardiovascular risk reduction in people with spinal
   cord injury: physical activity, healthy diet and maintenance after
   discharge-protocol for a prospective national cohort study and a
   preintervention-postintervention study
SO BMJ OPEN
LA English
DT Article
ID QUALITY-OF-LIFE; STEPPER EXERCISE TEST; INDEPENDENCE MEASURE;
   NEUROLOGICAL CLASSIFICATION; LONGITUDINAL RELATIONSHIP; CARDIOMETABOLIC
   SYNDROME; BEHAVIORAL INTERVENTION; INTERNATIONAL STANDARDS; PATIENT
   EDUCATION; BODY-COMPOSITION
AB Introduction Spinal cord injury (SCI) predisposes those who suffer from it to physical inactivity and weight gain; consequently, death due to cardiovascular diseases is more frequent among people with SCI than in the general population. The literature documents a consensus about an interdisciplinary multimodal approach for the prevention and treatment of cardiovascular risk factors including overweight and obesity in people with SCI, focusing on diet, physical activity (PA) and behavioural interventions. This study will investigate implementation of recommendations from a recent clinical practice guideline for identification and management of cardiometabolic risk after SCI through multimodal patient education in a subacute clinical setting.
   Methods and analysis All patients who are aged 18 years or older with an SCI within the previous 12 months and admitted to highly specialised rehabilitation are included, regardless of SCI aetiology or neurological level. A primary study designed as a controlled, pragmatic, preintervention- postintervention study with 6-month follow-up evaluates the effect of the clinical intervention; a prospective national cohort study on body mass index (BMI) serves as a historical control. The intervention consists of a standardised approach to patient education about cardiovascular risk factors, PA and a healthy diet that begins at the outset of primary SCI rehabilitation and is integrated into existing settings and workflows. Outcome measures are collected at admission, discharge and 6 months after discharge and include peak oxygen uptake (VO2peak) (primary outcome), BMI, body composition, metabolic profile, neurological status, level of functioning, depression, quality of life, objective PA (accelerometry), self-reported PA, self-assessed PA ability, shared decision making, and dietary habits. Test-retest reliability of four VO2peak test protocols are investigated, as is test-retest reliability of a multisensor accelerometer in a rehabilitation setting.
   Ethics and dissemination The project is approved by the Committees on Health Research Ethics in the Capital Region of Denmark on 10 July 2018 (Journal-nr.: H-18018325). The principal investigator obtains informed consent from all participants. The interventions in the project are closely related to existing rehabilitation care, and the risk of pain and discomfort is considered modest. Any unintended events related to the elements of the intervention are reported, according to existing regional procedures. Data are stored in a secure web-based database (Redcap). The primary study and prospective cohort study are registered at Clinicaltrials.gov. Positive and negative results will be submitted to relevant scientific journals related to SCI for publication. Important protocol modifications are reported to the Committees on Health Research Ethics in the Capital Region of Denmark.
C1 [Holm, Nicolaj Jersild; Dalsgaard, Line Trine; Biering-Sorensen, Fin] Rigshosp, Clin Spinal Cord Injuries, Ctr Neurosci, Hornbaek, Denmark.
   [Moller, Tom; Adamsen, Lis] Rigshosp, Dept 9701, Univ Hosp Ctr Hlth Res, UCSF Copenhagen Univ Hosp, Copenhagen, Denmark.
   [Schou, Lone Helle] Univ Coll Copenhagen, Dept Nursing & Nutr, Copenhagen, Denmark.
C3 Rigshospitalet; University of Copenhagen; Copenhagen University
   Hospital; Rigshospitalet; University College Copenhagen
RP Holm, NJ (corresponding author), Rigshosp, Clin Spinal Cord Injuries, Ctr Neurosci, Hornbaek, Denmark.
EM nicolaj.jersild.holm@regionh.dk
RI Schou, Lone/AAE-5184-2021
OI Moller, Tom/0000-0003-1908-258X; Schou, Lone Helle/0000-0002-5465-6246
FU research programme, 'Centre for Integrated Rehabilitation of Cancer
   Patients (CIRE)-Neuro/Psychology'
FX This work was supported by a research programme, 'Centre for Integrated
   Rehabilitation of Cancer Patients (CIRE)-Neuro/Psychology,' conducted
   collaboratively by the University Hospitals Centre for Health
   CareHealthcare Research, University Hospital Copenhagen, Rigshospitalet,
   University College Copenhagen, Department of Nursing and Nutrition, and
   the NeuroScience Centre, Rigshospitalet.
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   Zanca JM, 2013, ARCH PHYS MED REHAB, V94, pS137, DOI 10.1016/j.apmr.2012.10.035
NR 73
TC 10
Z9 11
U1 1
U2 9
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2044-6055
J9 BMJ OPEN
JI BMJ Open
PD DEC
PY 2019
VL 9
IS 12
AR e030310
DI 10.1136/bmjopen-2019-030310
PG 12
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA KK5HS
UT WOS:000512773400057
PM 31892644
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Jamshed, H
   Steger, FL
   Bryan, DR
   Richman, JS
   Warriner, AH
   Hanick, CJ
   Martin, CK
   Salvy, SJ
   Peterson, CM
AF Jamshed, Humaira
   Steger, Felicia L.
   Bryan, David R.
   Richman, Joshua S.
   Warriner, Amy H.
   Hanick, Cody J.
   Martin, Corby K.
   Salvy, Sarah-Jeanne
   Peterson, Courtney M.
TI Effectiveness of Early Time-Restricted Eating for Weight Loss, Fat Loss,
   and Cardiometabolic Health in Adults With Obesity A Randomized Clinical
   Trial
SO JAMA INTERNAL MEDICINE
LA English
DT Article
ID REDUCED MEAL FREQUENCY; CALORIE RESTRICTION; INTERMITTENT ENERGY;
   BLOOD-PRESSURE; 8 WK; DIET; MEN; MARKERS; RISK; RESISTANCE
AB IMPORTANCE It is unclear how effective intermittent fasting is for losing weight and body fat, and the effects may depend on the timing of the eating window. This randomized trial compared time-restricted eating (TRE) with eating over a period of 12 or more hours while matching weight-loss counseling across groups.
   OBJECTIVE To determine whether practicing TRE by eating early in the day (eTRE) is more effective for weight loss, fat loss, and cardiometabolic health than eating over a period of 12 or more hours.
   DESIGN, SETTING. AND PARTICIPANTS The study was a 14-week, parallel-arm, randomized clinical trial conducted between August 2018 and April 2020. Participants were adults aged 25 to 75 years with obesity and who received weight-loss treatment through the Weight Loss Medicine Clinic at the University of Alabama at Birmingham Hospital.
   INTERVENTIONS All participants received weight-loss treatment (energy restriction [ER]) and were randomized to eTRE plus ER (8-hour eating window from 7:00 to 15:00) or control eating (CON) plus ER (>= 12-hour window).
   MAIN OUTCOMES AND MEASURES The co-primary outcomes were weight loss and fat loss. Secondary outcomes included blood pressure, heart rate, glucose levels, insulin levels, and plasma lipid levels.
   RESULTS Ninety participants were enrolled (mean [SD] body mass index, 39.6 [6.7]; age, 43 [11] years; 72 [80%) female). The eTRE+ER group adhered 6.0 (0.8) days per week. The eTRE+ER intervention was more effective for losing weight (-2.3 kg; 95% CI, -3.7 to -0.9 kg; P = .002) but did not affect body fat (-1.4 kg; 95% CI, -2.9 to 0.2 kg; P = .09) or the ratio of fat loss to weight loss (-4.2%; 95% CI, -14.9 to 6.5%; P = .43). The effects of eTRE+ER were equivalent to reducing calorie intake by an additional 214 kcal/d. The eTRE+ER intervention also improved diastolic blood pressure (-4 mm Hg; 95% CI, -8 to 0 mm Hg; P = .04) and mood disturbances, including fatigue-inertia, vigor-activity, and depression-dejection. All other cardiometabolic risk factors, food intake, physical activity, and sleep outcomes were similar between groups. In a secondary analysis of 59 completers, eTRE+ER was also more effective for losing body fat and trunk fat than CON+ER.
   CONCLUSIONS AND RELEVANCE In this randomized clinical trial, eTRE was more effective for losing weight and improving diastolic blood pressure and mood than eating over a window of 12 or more hours at 14 weeks.
C1 [Jamshed, Humaira; Steger, Felicia L.; Bryan, David R.; Hanick, Cody J.; Peterson, Courtney M.] Univ Alabama Birmingham, Dept Nutr Sci, Birmingham, AL 35233 USA.
   [Jamshed, Humaira] Habib Univ, Dept Integrated Sci & Math, Karachi, Sindh, Pakistan.
   [Steger, Felicia L.] Univ Kansas, Med Ctr, Dept Endocrinol Genet & Metab, Kansas City, KS 66103 USA.
   [Richman, Joshua S.] Univ Alabama Birmingham, Dept Surg, Birmingham, AL 35233 USA.
   [Warriner, Amy H.] Univ Alabama Birmingham, Dept Med, Birmingham, AL 35233 USA.
   [Martin, Corby K.] Pennington Biomed Res Ctr, Baton Rouge Louisiana, 6400 Perkins Rd, Baton Rouge, LA 70808 USA.
   [Salvy, Sarah-Jeanne] Cedars Sinai Med Ctr, Los Angeles, CA 90048 USA.
C3 University of Alabama System; University of Alabama Birmingham;
   University of Kansas; University of Kansas Medical Center; University of
   Alabama System; University of Alabama Birmingham; University of Alabama
   System; University of Alabama Birmingham; Louisiana State University
   System; Louisiana State University; Pennington Biomedical Research
   Center; Cedars Sinai Medical Center
RP Peterson, CM (corresponding author), Univ Alabama Birmingham, 1675 Univ Blvd,Webb 644, Birmingham, AL 35233 USA.
EM cpeterso@uab.edu
RI Jamshed, Humaira/I-4739-2019; Steger, Felicia/GPF-8493-2022; Martin,
   Corby/N-1976-2017
OI Salvy, Sarah-Jeanne/0000-0002-8202-182X; Steger,
   Felicia/0000-0002-8117-4082; Jamshed, Humaira/0000-0002-3386-3748
FU National Center for Advancing Translational Sciences of the NIH [UL1
   TR001419]; National Institute of Diabetes and Digestive and Kidney
   Diseases [P30 DK056336]; Nutrition Obesity Research Center (NORC) [P30
   DK056336, P30 DK072476]; Diabetes Research Center (DRC) [P30 DK079626];
   NIH Predoctoral T32 Obesity Fellowship [T32 HL105349]; Louisiana
   Clinical and Translational Science Center (LA CaTS) [U54 GM104940]
FX This study was supported by grants UL1 TR001419 from the National Center
   for Advancing Translational Sciences of the NIH and P30 DK056336 from
   the National Institute of Diabetes and Digestive and Kidney Diseases.
   Resources and support were also provided by 2 Nutrition Obesity Research
   Center (NORC) grants (P30 DK056336; P30 DK072476), a Diabetes Research
   Center (DRC) grant (P30 DK079626), an NIH Predoctoral T32 Obesity
   Fellowship to Mr Hanick (T32 HL105349), and the Louisiana Clinical and
   Translational Science Center (LA CaTS; U54 GM104940).
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NR 74
TC 144
Z9 152
U1 15
U2 169
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 2168-6106
EI 2168-6114
J9 JAMA INTERN MED
JI JAMA Intern. Med.
PD SEP
PY 2022
VL 182
IS 9
BP 953
EP 962
DI 10.1001/jamainternmed.2022.3050
EA AUG 2022
PG 10
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 4J9JN
UT WOS:000839635700002
PM 35939311
OA Green Published
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Goluchowska, A
   Rebowska, E
   Drygas, W
   Jegier, A
AF Goluchowska, Agnieszka
   Rebowska, Ewa
   Drygas, Wojciech
   Jegier, Anna
TI Metabolic risk in men with ischaemic heart disease and their
   participation in ambulatory comprehensive cardiac rehabilitation
SO KARDIOLOGIA POLSKA
LA English
DT Article
DE metabolic risk; metabolic syndrome; ischaemic heart disease;
   comprehensive cardiac rehabilitation
ID EXERCISE; ASSOCIATION; PREVENTION; STATEMENT
AB Background: With a growing population of patients with ischaemic heart disease (IHD), the number of interventional cardiology and cardiac surgery procedures is also increasing. This is particularly the case for patients with multivessel coronary disease who are treated with percutaneous coronary interventions (PCI) and coronary artery bypass grafting (CABG). A considerable part of the IHD population are subjects with metabolic syndrome (MetS) who participate in comprehensive cardiac rehabilitation (CCR) programs as a part of secondary prevention of cardiovascular disease.
   Aim: To evaluate prospectively conventional risk factors within MetS, including uric acid (UA) level, in men with IHD after PCI or CABG who participated in ambulatory CCR.
   Methods: The study included 90 adult men (mean age 59.1 +/- 7.31 years) with IHD after PCI (n = 63, 70%) or CABG (n = 27, 30%) referred for ambulatory CCR on average 30-60 days after an acute coronary syndrome. All subjects were examined twice 2 months apart - at the referral for CCR and after completion of CCR. MetS was diagnosed based on the measurement of systolic and diastolic blood pressure, waist circumference (WC), and high-density lipoprotein cholesterol, triglyceride (TG), and fasting blood glucose levels. In all subjects, UA level was also measured and the waist-to-hip ratio (WHR) and body mass index (BMI) were calculated. Following clinical evaluation and exercise test, each patient underwent 24 interval training sessions on a cycle ergometer. The patients received drug therapy including beta-blockers, angiotensin-converting enzyme inhibitors, statins, and acetylsalicylic acid. As a part of CCR, the patients also received education regarding healthy lifestyle changes including physical activity, healthy diet, stress coping techniques, effects of nicotine and alcohol, and effective methods to eliminate these habits.
   Results: In most subjects, WC, BMI and WHR did not change significantly after the period of 2 months of CCR, and WC and BMI increased in the CABG subgroup (p = 0.00003 and p = 0.0178, respectively). Irrespective of the type of cardiac intervention, significant increases in exercise capacity and physical effort tolerance were observed after 2 months of CCR (p < 0.00001). TG level increased in all participants (p = 0.0514) and in the PCI subgroup (p = 0.0489). Systolic blood pressure decreased in all participants (p = 0.0216) and in the PCI subgroup (p = 0.0043). Mean UA level also decreased in all patients regardless of the type of cardiac intervention. Overall, the proportion of patients with the diagnosis of MetS did not change significantly after 2 months of CCR (36% vs. 31%, p > 0.05). However, the rate of MetS decreased in the PCI subgroup (from 46% to 29%, p = 0.043) and increased in the CABG subgroup (from 11% do 37%, p = 0.0562).
   Conclusions: The effect of participation in CCR on the metabolic risk in men with IHD varies depending on the type of earlier cardiac intervention. The metabolic risk decreased in patients treated with PCI, while it increased in those treated with CABG. In order to reduce the metabolic risk, particularly in CABG patients, a CCR program requires intensification of the patient support including educational activities regarding diet and weight reduction as well as individually prescribed physical activity.
C1 [Goluchowska, Agnieszka; Jegier, Anna] Med Univ Lodz, Dept Sports Med, PL-92213 Lodz, Poland.
   [Rebowska, Ewa; Drygas, Wojciech] Med Univ Lodz, Dept Prevent Med, PL-92213 Lodz, Poland.
C3 Medical University Lodz; Medical University Lodz
RP Goluchowska, A (corresponding author), Med Univ Lodz, Dept Sports Med, Ul Pomorska 251, PL-92213 Lodz, Poland.
EM agnieszka.goluchowska@umed.lodz.pl
RI Drygas, Wojciech/GLR-9863-2022
OI Drygas, Wojciech/0000-0002-4351-6459; Rebowska, Ewa/0000-0002-3620-588X;
   Goluchowska, Agnieszka/0000-0001-8418-7930; Jegier,
   Anna/0000-0003-4737-2226
FU Medical University of Lodz [502-03/6-029-05/502-64-014]
FX The study was supported by the Medical University of Lodz, research
   project No. 502-03/6-029-05/502-64-014.
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   World Health Report, 2008, WORLD HLTH REP
NR 25
TC 3
Z9 3
U1 0
U2 12
PU POLISH CARDIAC SOC
PI WARSZAWA
PA UL STAWKI 3 A LOK 1-2, WARSZAWA, POLAND
SN 0022-9032
EI 1897-4279
J9 KARDIOL POL
JI Kardiol. Pol.
PY 2015
VL 73
IS 8
BP 656
EP 663
DI 10.5603/KP.a2015.0052
PG 8
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA CP8GV
UT WOS:000360131800011
PM 25761789
OA hybrid
DA 2025-06-11
ER

PT J
AU Tsai, HH
   Tantoh, DM
   Lu, WY
   Chen, CY
   Liaw, YP
AF Tsai, Hao-Hung
   Tantoh, Disline Manli
   Lu, Wen Yu
   Chen, Chih-Yi
   Liaw, Yung-Po
TI Cigarette smoking and PM2.5 might jointly exacerbate the risk
   of metabolic syndrome
SO FRONTIERS IN PUBLIC HEALTH
LA English
DT Article
DE cigarette smoking; PM2.5; interaction; adults; Taiwan
ID LONG-TERM EXPOSURE; PARTICULATE AIR-POLLUTION; HOSPITAL ADMISSIONS;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; ASSOCIATION; MORTALITY; MATTER;
   DISEASE; NATIONWIDE
AB Background: Cigarette smoking and particulate matter (PM) with aerodynamic diameter < 2.5 mu m (PM2.5) are major preventable cardiovascular mortality and morbidity promoters. Their joint role in metabolic syndrome (MS) pathogenesis is unknown. We determined the risk of MS based on PM2.5 and cigarette smoking in Taiwanese adults. Methods: The study included 126,366 Taiwanese between 30 and 70 years old with no personal history of cancer. The Taiwan Biobank (TWB) contained information on MS, cigarette smoking, and covariates, while the Environmental Protection Administration (EPA), Taiwan, contained the PM2.5 information. Individuals were categorized as current, former, and nonsmokers. PM2.5 levels were categorized into quartiles: PM2.5 <= Q1, Q1 < PM2.5 <= Q2, Q2 < PM2.5 <= Q3, and PM2.5 > Q3, corresponding to PM2.5 <= 27.137, 27.137 < PM2.5 <= 32.589, 32.589 < PM2.5 <= 38.205, and PM2.5 > 38.205 mu g/m(3). Results: The prevalence of MS was significantly different according to PM2.5 exposure (p-value = 0.0280) and cigarette smoking (p-value < 0.0001). Higher PM2.5 levels were significantly associated with a higher risk of MS: odds ratio (OR); 95% confidence interval (CI) = 1.058; 1.014-1.104, 1.185; 1.134-1.238, and 1.149; 1.101-1.200 for 27.137 < PM2.5 <= 32.589, 32.589 < PM2.5 <= 38.205, and PM2.5 > 38.205 mu g/m(3), respectively. The risk of MS was significantly higher among former and current smokers with OR; 95% CI = 1.062; 1.008-1.118 and 1.531; 1.450-1.616, respectively, and a dose-dependent p-value < 0.0001. The interaction between both exposures regarding MS was significant (p-value = 0.0157). Stratification by cigarette smoking revealed a significant risk of MS due to PM2.5 exposure among nonsmokers: OR (95% CI) = 1.074 (1.022-1.128), 1.226 (1.166-1.290), and 1.187 (1.129-1.247) for 27.137 < PM2.5 <= 32.589, 32.589 < PM2.5 <= 38.205, and PM2.5 > 38.205 mu g/m(3), respectively. According to PM2.5 quartiles, current smokers had a higher risk of MS, regardless of PM2.5 levels (OR); 95% CI = 1.605; 1.444-1.785, 1.561; 1.409-1.728, 1.359; 1.211-1.524, and 1.585; 1.418-1.772 for PM2.5 <= 27.137, 27.137 < PM2.5 <= 32.589, 32.589 < PM2.5 <= 38.205, and PM2.5 > 38.205 mu g/m(3), respectively. After combining both exposures, the group, current smokers; PM2.5 > 38.205 mu g/m(3) had the highest odds (1.801; 95% CI =1.625-1.995). Conclusion: PM2.5 and cigarette smoking were independently and jointly associated with a higher risk of MS. Stratified analyses revealed that cigarette smoking might have a much higher effect on MS than PM2.5. Nonetheless, exposure to both PM2.5 and cigarette smoking could compound the risk of MS.
C1 [Tsai, Hao-Hung; Chen, Chih-Yi] Chung Shan Med Univ, Inst Med, Taichung, Taiwan.
   [Tsai, Hao-Hung] Chung Shan Med Univ, Inst Med, Taichung, Taiwan.
   [Tsai, Hao-Hung; Tantoh, Disline Manli; Liaw, Yung-Po] Chung Shan Med Univ Hosp, Dept Med Imaging, Taichung, Taiwan.
   [Tsai, Hao-Hung] Chung Shan Med Univ Hosp, Dept Med Imaging, Sch Med, Taichung, Taiwan.
   [Tsai, Hao-Hung] Chung Shan Med Univ, Dept Med Imaging & Radiol Sci, Taichung, Taiwan.
   [Tantoh, Disline Manli; Lu, Wen Yu; Liaw, Yung-Po] Chung Shan Med Univ, Dept Publ Hlth, Taichung, Taiwan.
   [Tantoh, Disline Manli; Lu, Wen Yu; Liaw, Yung-Po] Chung Shan Med Univ, Inst Publ Hlth, Taichung, Taiwan.
   [Chen, Chih-Yi] Chung Shan Med Univ Hosp, Dept Surg, Div Thorac Surg, Taichung, Taiwan.
C3 Chung Shan Medical University; Chung Shan Medical University; Chung Shan
   Medical University; Chung Shan Medical University Hospital; Chung Shan
   Medical University; Chung Shan Medical University Hospital; Chung Shan
   Medical University; Chung Shan Medical University; Chung Shan Medical
   University; Chung Shan Medical University; Chung Shan Medical University
   Hospital
RP Chen, CY (corresponding author), Chung Shan Med Univ, Inst Med, Taichung, Taiwan.; Liaw, YP (corresponding author), Chung Shan Med Univ Hosp, Dept Med Imaging, Taichung, Taiwan.; Liaw, YP (corresponding author), Chung Shan Med Univ, Dept Publ Hlth, Taichung, Taiwan.; Liaw, YP (corresponding author), Chung Shan Med Univ, Inst Publ Hlth, Taichung, Taiwan.; Chen, CY (corresponding author), Chung Shan Med Univ Hosp, Dept Surg, Div Thorac Surg, Taichung, Taiwan.
EM Cshy1566@csh.org.tw; Liawyp@csmu.edu.tw
RI Tantoh, Disline/IAQ-3602-2023; Yi-Wen, Chen/G-7275-2016; Liaw,
   Yung/AAV-6746-2021
OI Liaw, Yung-Po/0000-0003-2046-4964
FU Ministry of Science and Technology (MOST), Taiwan [MOST
   111-2121-M-040-002]
FX The Ministry of Science and Technology (MOST), Taiwan, funded this study
   (MOST 111-2121-M-040-002).
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NR 83
TC 3
Z9 3
U1 16
U2 35
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 2296-2565
J9 FRONT PUBLIC HEALTH
JI Front. Public Health
PD JAN 15
PY 2024
VL 11
AR 1234799
DI 10.3389/fpubh.2023.1234799
PG 13
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA GI6S1
UT WOS:001152083900001
PM 38288423
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Mougeot, JLC
   Noll, BD
   Mougeot, FKB
AF Mougeot, J-L C.
   Noll, B. D.
   Mougeot, F. K. Bahrani
TI Sjogren's syndrome X-chromosome dose effect: An epigenetic perspective
SO ORAL DISEASES
LA English
DT Review
DE autoimmune; epigenetic; methylation; polycomb; Sjogren's syndrome;
   X-chromosome inactivation
ID SYSTEMIC-LUPUS-ERYTHEMATOSUS; RHEUMATISM CLASSIFICATION CRITERIA; 2016
   AMERICAN-COLLEGE; SYNDROME DRY EYE; DNA METHYLATION; SALIVARY-GLAND;
   TRANSCRIPTION-FACTOR; RHEUMATOLOGY/EUROPEAN LEAGUE; MULTIFACETED
   FUNCTIONS; OXIDATIVE STRESS
AB Sjogren's syndrome (SS) is a chronic autoimmune disease affecting exocrine glands leading to mouth and eyes dryness. The extent to which epigenetic DNA methylation changes are responsible for an X-chromosome dose effect has yet to be determined. Our objectives were to (i) describe how epigenetic DNA methylation changes could explain an X-chromosome dose effect in SS for women with normal 46,XX genotype and (ii) determine the relevant relationships to this dose effect, between X-linked genes, genes controlling X-chromosome inactivation (XCI) and genes encoding associated transcription factors, all of which are differentially expressed and/or differentially methylated in the salivary glands of patients with SS. We identified 58 upregulated X-chromosome genes, including 22 genes previously shown to escape XCI, based on the analysis of SS patient salivary gland GEO2R gene expression datasets. Moreover, we found XIST and its cis regulators RLIM, FTX, and CHIC1, and polycomb repressor genes of the PRC1/2 complexes to be upregulated. Many of the X-chromosome genes implicated in SS pathogenesis can be regulated by transcription factors which we found to be overexpressed and/or differentially methylated in patients with SS. Determination of the mechanisms underlying methylation-dependent gene expression and impaired XCI is needed to further elucidate the etiopathogenesis of SS.
C1 [Mougeot, J-L C.; Noll, B. D.; Mougeot, F. K. Bahrani] Carolinas HealthCare Syst, Cannon Res Ctr, Dept Oral Med, Charlotte, NC USA.
   [Mougeot, J-L C.; Noll, B. D.; Mougeot, F. K. Bahrani] Univ North Carolina Charlotte, Dept Biol Sci, Charlotte, NC USA.
C3 Carolinas HealthCare System; University of North Carolina; University of
   North Carolina Charlotte
RP Mougeot, JLC (corresponding author), Carolinas HealthCare Syst, Dept Oral Med, Charlotte, NC 28203 USA.
EM jean-luc.mougeot@carolinashealthcare.org
FU Carolinas HealthCare System Research Fund
FX Carolinas HealthCare System Research Fund
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NR 88
TC 33
Z9 34
U1 0
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1354-523X
EI 1601-0825
J9 ORAL DIS
JI Oral Dis.
PD MAR
PY 2019
VL 25
IS 2
BP 372
EP 384
DI 10.1111/odi.12825
PG 13
WC Dentistry, Oral Surgery & Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dentistry, Oral Surgery & Medicine
GA HL7DT
UT WOS:000458899300004
PM 29316023
DA 2025-06-11
ER

PT J
AU Szczepanska-Sadowska, E
AF Szczepanska-Sadowska, Ewa
TI Neuromodulation of Cardiac Ischemic Pain: Role of the Autonomic Nervous
   System and Vasopressin
SO JOURNAL OF INTEGRATIVE NEUROSCIENCE
LA English
DT Review
DE pain; cardiac hypoxia; brain; spinal cord; myocardial infarction;
   autacoids; angiotensin; endothelin; vaptans
ID SPINAL-CORD STIMULATION; PLASMA ARGININE-VASOPRESSIN; SPINOTHALAMIC
   TRACT NEURONS; HEART-RATE-VARIABILITY; SENSING ION-CHANNEL;
   MYOCARDIAL-ISCHEMIA; MESSENGER-RNA; CHEST-PAIN; SYMPATHETIC AFFERENTS;
   CIRCADIAN VARIATION
AB Cardiac pain is an index of cardiac ischemia that helps the detection of cardiac hypoxia and adjustment of activity in the sufferer. Drivers and thresholds of cardiac pain markedly differ in different subjects and can oscillate in the same individual, showing a distinct circadian rhythmicity and clinical picture. In patients with syndrome X or silent ischemia, cardiac pain intensity may cause neurogenic stress that potentiates the cardiac work and intensifies the cardiac hypoxia and discomfort of the patient. The reasons for individual differences in cardiac pain sensation are not fully understood. Thus far, most attention has been focused on inappropriate regulation of the heart by the autonomic nervous system, autacoids, and cardiovascular hormones. Herein, we summarize evidence showing that the autonomic nervous system regulates cardiac pain sensation in cooperation with vasopressin (AVP). AVP is an essential analgesic compound and it exerts its antinociceptive function through actions in the brain (the periaqueductal gray, caudate nucleus, nucleus raphe magnus), spinal cord, and heart and coronary vessels. Vasopressin acts directly by means of V1 and V2 receptors as well as through multiple interactions with the autonomic nervous system and cardiovascular hormones, in particular, angiotensin II and endothelin. The pain regulatory effects of the autonomic nervous system and vasopressin are significantly impaired in cardiovascular diseases.
C1 [Szczepanska-Sadowska, Ewa] Med Univ Warsaw, Lab Ctr Preclin Res, Dept Expt & Clin Physiol, PL-02097 Warsaw, Poland.
C3 Medical University of Warsaw
RP Szczepanska-Sadowska, E (corresponding author), Med Univ Warsaw, Lab Ctr Preclin Res, Dept Expt & Clin Physiol, PL-02097 Warsaw, Poland.
EM eszczepanska@wum.edu.pl
RI Szczepanska-Sadowska, Ewa/AGQ-9776-2022
OI Szczepanska-Sadowska, Ewa/0000-0002-3761-508X
FU Medical University of Warsaw Scientific Projects [1MA/N/2022]
FX This work was supported by the Medical University of Warsaw Scientific
   Projects (1MA/N/2022). The work did not receive any specific grant from
   funding agencies in the public, commercial, or not-for-profit sectors.
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NR 148
TC 4
Z9 4
U1 1
U2 1
PU IMR PRESS
PI ROBINSON
PA 112 ROBINSON RD, ROBINSON, SINGAPORE
SN 0219-6352
EI 1757-448X
J9 J INTEGR NEUROSCI
JI J. Integr. Neurosci.
PD MAR
PY 2024
VL 23
IS 3
AR 49
DI 10.31083/j.jin2303049
PG 11
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA MT1O5
UT WOS:001195796800019
PM 38538221
OA gold
DA 2025-06-11
ER

PT J
AU Michallek, F
   Nakamura, S
   Ota, H
   Ogawa, R
   Shizuka, T
   Nakashima, H
   Wang, YN
   Ito, T
   Sakuma, H
   Dewey, M
   Kitagawa, K
AF Michallek, Florian
   Nakamura, Satoshi
   Ota, Hideki
   Ogawa, Ryo
   Shizuka, Takehito
   Nakashima, Hitoshi
   Wang, Yi-Ning
   Ito, Tatsuro
   Sakuma, Hajime
   Dewey, Marc
   Kitagawa, Kakuya
TI Fractal analysis of 4D dynamic myocardial stress-CT perfusion imaging
   differentiates micro- and macrovascular ischemia in a multi-center
   proof-of-concept study
SO SCIENTIFIC REPORTS
LA English
DT Article
ID CORONARY MICROVASCULAR DYSFUNCTION; POSITRON-EMISSION-TOMOGRAPHY; STABLE
   ANGINA-PECTORIS; BLOOD-FLOW; HEART-DISEASE; ARTERY-DISEASE; SYNDROME-X;
   ATHEROSCLEROSIS; QUANTIFICATION; MECHANISMS
AB Fractal analysis of dynamic, four-dimensional computed tomography myocardial perfusion (4D-CTP) imaging might have potential for noninvasive differentiation of microvascular ischemia and macrovascular coronary artery disease (CAD) using fractal dimension (FD) as quantitative parameter for perfusion complexity. This multi-center proof-of-concept study included 30 rigorously characterized patients from the AMPLIFiED trial with nonoverlapping and confirmed microvascular ischemia (n(micro) = 10), macrovascular CAD (n(macro) = 10), or normal myocardial perfusion (n(normal) = 10) with invasive coronary angiography and fractional flow reserve (FFR) measurements as reference standard. Perfusion complexity was comparatively high in normal perfusion (FDnormal = 4.49, interquartile range [IQR]:4.46-4.53), moderately reduced in microvascular ischemia (FDmicro = 4.37, IQR:4.36-4.37), and strongly reduced in macrovascular CAD (FDmacro = 4.26, IQR:4.24-4.27), which allowed to differentiate both ischemia types, p < 0.001. Fractal analysis agreed excellently with perfusion state (kappa = 0.96, AUC = 0.98), whereas myocardial blood flow (MBF) showed moderate agreement (kappa = 0.77, AUC = 0.78). For detecting CAD patients, fractal analysis outperformed MBF estimation with sensitivity and specificity of 100% and 85% versus 100% and 25%, p = 0.02. In conclusion, fractal analysis of 4D-CTP allows to differentiate microvascular from macrovascular ischemia and improves detection of hemodynamically significant CAD in comparison to MBF estimation.
C1 [Michallek, Florian; Dewey, Marc] Charite Univ Med Berlin, Dept Radiol, Charitepl 1, D-10117 Berlin, Germany.
   [Michallek, Florian; Dewey, Marc] Free Univ Berlin, Charitepl 1, D-10117 Berlin, Germany.
   [Michallek, Florian; Dewey, Marc] Humboldt Univ, Charitepl 1, D-10117 Berlin, Germany.
   [Michallek, Florian; Dewey, Marc] Berlin Inst Hlth, Charitepl 1, D-10117 Berlin, Germany.
   [Nakamura, Satoshi; Sakuma, Hajime] Mie Univ, Dept Radiol, Grad Sch Med, Tsu, Mie, Japan.
   [Ota, Hideki] Tohoku Univ, Dept Adv MRI Collaborat Res, Grad Sch Med, Sendai, Miyagi, Japan.
   [Ogawa, Ryo] Saiseikai Matsuyama Hosp, Matsuyama, Ehime, Japan.
   [Shizuka, Takehito] Takasaki Gen Med Ctr, Takasaki, Gumma, Japan.
   [Nakashima, Hitoshi] Natl Hosp Org, Kagoshima Med Ctr, Kagoshima, Japan.
   [Wang, Yi-Ning] Peking Union Med Coll Hosp, Beijing, Peoples R China.
   [Ito, Tatsuro] Kobe Univ, Grad Sch Med, Kobe, Hyogo, Japan.
   [Dewey, Marc] DZHK German Ctr Cardiovasc Res, Partner Site Berlin, Berlin, Germany.
   [Kitagawa, Kakuya] Mie Univ, Dept Adv Diagnost Imaging, Grad Sch Med, Tsu, Mie, Japan.
C3 Berlin Institute of Health; Free University of Berlin; Humboldt
   University of Berlin; Charite Universitatsmedizin Berlin; Berlin
   Institute of Health; Free University of Berlin; Humboldt University of
   Berlin; Charite Universitatsmedizin Berlin; Berlin Institute of Health;
   Free University of Berlin; Humboldt University of Berlin; Charite
   Universitatsmedizin Berlin; Berlin Institute of Health; Free University
   of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin
   Berlin; Mie University; Tohoku University; Chinese Academy of Medical
   Sciences - Peking Union Medical College; Peking Union Medical College
   Hospital; Kobe University; German Centre for Cardiovascular Research;
   Mie University
RP Michallek, F; Dewey, M (corresponding author), Charite Univ Med Berlin, Dept Radiol, Charitepl 1, D-10117 Berlin, Germany.; Michallek, F; Dewey, M (corresponding author), Free Univ Berlin, Charitepl 1, D-10117 Berlin, Germany.; Michallek, F; Dewey, M (corresponding author), Humboldt Univ, Charitepl 1, D-10117 Berlin, Germany.; Michallek, F; Dewey, M (corresponding author), Berlin Inst Hlth, Charitepl 1, D-10117 Berlin, Germany.; Dewey, M (corresponding author), DZHK German Ctr Cardiovasc Res, Partner Site Berlin, Berlin, Germany.
EM florian.michallek@charite.de; marc.dewey@charite.de
RI Ota, Hideki/A-3717-2012; Michallek, Florian/GXV-4955-2022; Wang,
   Yining/IQU-9800-2023
OI Michallek, Florian/0000-0002-5475-0873; Nakamura,
   Satoshi/0000-0002-9634-9332; Wang, Yining/0000-0001-5671-7957; Dewey,
   Marc/0000-0002-4402-2733
FU German Research Foundation [392304398, Ml 2272/1-1, DE 1361/18-1]
FX We thank Bettina Herwig for assistance with language editing and all
   AMPLIFiED trial personnel for the support in patient recruitment and
   data handling. FM and MD are grateful for the funding received from the
   German Research Foundation for this project (DFG, project number
   392304398, grants Ml 2272/1-1 and DE 1361/18-1).
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NR 53
TC 9
Z9 10
U1 0
U2 2
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD MAR 24
PY 2022
VL 12
IS 1
AR 5085
DI 10.1038/s41598-022-09144-6
PG 13
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA ZZ1AW
UT WOS:000773009200053
PM 35332236
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Akashi, YJ
   Nakazawa, K
   Sakakibara, M
   Miyake, F
   Koike, H
   Sasaka, K
AF Akashi, YJ
   Nakazawa, K
   Sakakibara, M
   Miyake, F
   Koike, H
   Sasaka, K
TI The clinical features of takotsubo cardiomyopathy
SO QJM-AN INTERNATIONAL JOURNAL OF MEDICINE
LA English
DT Article
ID LEFT-VENTRICULAR DYSFUNCTION; ST-SEGMENT ELEVATION; BRAIN NATRIURETIC
   PEPTIDE; CATECHOLAMINE-INDUCED CARDIOMYOPATHY; SYNDROME-X; SUBARACHNOID
   HEMORRHAGE; AMPULLA CARDIOMYOPATHY; MYOCARDIAL-INFARCTION; CARDIAC
   DYSFUNCTION; HEART-FAILURE
AB Background: Cardiologists have recently recognized a reversible form of heart failure of unknown origin characterized by a takotsubo-shaped hypokinesis of the left ventricle on left ventriculography.
   Aim: To clarify the clinical features of this cardiomyopathy.
   Design: Observational study.
   Methods: Seven patients with reversible ventricular dysfunction were followed for 4.5 years. Clinical course, routine examinations, and cardiac catheterizations in each patient were documented.
   Results: The cardiomyopathy developed in six elderly female and one male patients (mean age 75.3 years), all of whom had been exposed to stress. Cardiac enzymes did not significantly increase, but serum norepinephrine increased remarkably (1.19 ng/ml). Coronary angiography revealed normal coronary arteries. However, left ventriculography showed akinesis in the apical segments, together with hyperkinesis in the basal segments (a takotsubo shape). The abnormal kinesis normalized within 17.4 hospital days without any treatment in five patients, and with haemodynamic support for 3 days in the other two. Endocardial biopsies did not suggest any specific pathology. The cardiac events did not recur over a 1-4 year follow-up.
   Discussion: Coronary vasospasm, myocarditis and other substantial diseases previously described were ruled out as the cause of takotsubo cardiomyopathy in our subjects. Prognosis was good without any form of treatment, provided that the patients survived the severe heart failure state. Catecholaminergic or adrenoceptor-hyperactive cardiomyopathy may be the cause of this cardiomyopathy.
C1 St Marianna Univ, Div Cardiol, Dept Internal Med, Sch Med,Miyamae Ku, Kawasaki, Kanagawa 2168511, Japan.
   St Marianna Univ, Dept Pathol, Sch Med, Miyamae Ku, Kawasaki, Kanagawa 2168511, Japan.
   St Marianna Univ, Dept Radiol, Sch Med, Miyamae Ku, Kawasaki, Kanagawa 2168511, Japan.
C3 Saint Marianna University; Saint Marianna University; Saint Marianna
   University
RP St Marianna Univ, Div Cardiol, Dept Internal Med, Sch Med,Miyamae Ku, 2-16-1 Sugao, Kawasaki, Kanagawa 2168511, Japan.
EM johnny@marianna-u.ac.jp
RI Akashi, Yoshihiro/J-8312-2019; Akashi, Yoshihiro/E-5227-2011
OI Akashi, Yoshihiro/0000-0001-7670-7326
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NR 41
TC 240
Z9 257
U1 0
U2 12
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1460-2725
EI 1460-2393
J9 QJM-INT J MED
JI QJM-An Int. J. Med.
PD AUG
PY 2003
VL 96
IS 8
BP 563
EP 573
DI 10.1093/qjmed/hcg096
PG 11
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 710MA
UT WOS:000184682900003
PM 12897341
DA 2025-06-11
ER

PT J
AU Talas, A
   Cerit, C
   Aslan, EA
AF Talas, Anil
   Cerit, Cem
   Aslan, Esma Akpinar
TI Comparison of the effects of sertraline and agomelatine on sleep
   quality, sexual functioning and metabolic parameters in patients with
   major depressive disorder
SO PSYCHIATRY AND CLINICAL PSYCHOPHARMACOLOGY
LA English
DT Article
DE Agomelatine; sertraline; sleep; sexuality; metabolic parameters
ID HEAD-TO-HEAD; ANTIDEPRESSANT EFFICACY; POOLED ANALYSIS; ESCITALOPRAM;
   ANXIETY; TOLERABILITY; RELIABILITY; EXPERIENCES; FLUOXETINE; SYMPTOMS
AB OBJECTIVE: This research aims to compare the effects of sertraline and agomelatine on outpatients diagnosed with a "major depressive episode" in terms of sleep quality, sexual functioning, and metabolic parameters related to metabolic syndrome. METHODS: This observational, open-labelled, 12-week follow-up study was carried out in the outpatient psychiatry clinic of a state research hospital. Included in the study were 60 outpatients admitted to the adult psychiatry clinic diagnosed with a "major depressive episode" who were subsequently prescribed agomelatine (25 mg/day) or sertraline (50 mg/day). Arizona Sexual Experience Scale (ASEX) and Pittsburgh Sleep Quality Index (PSQI) were performed during the 1st, 2nd, 4th, 8th and 12th weeks of treatment. The metabolic parameters; Body Mass Index, waist circumference, systolic and diastolic blood pressure, fasting blood glucose, liver enzymes (Alanine transaminase (ALT), Aspartate transaminase (AST) and lipid profiles - total cholesterol and total triglycerides, low density lipoprotein (LDL), high density lipoprotein and very low density lipoprotein - were assessed after the first interview (pre-treatment) and in the 12th week of treatment (post-treatment). RESULTS: The PSQI scores of both the sertraline and agomelatine groups had declined significantly by the end of the follow-up, with the decline in PSQI scores in the agomelatine group being higher than the decline in the sertraline group. The decline in the ASEX scores of the sertraline group was not significant, while the score was significant in the agomelatine group at the end of the follow-up. However, the difference in the changes in the ASEX scores between the study groups was not significant. The unfavourable changes noted in metabolic parameters were: elevation of the mean LDL level in patients using sertraline, and an elevation in liver enzymes (AST and ALT) in the patients using agomelatine. CONCLUSION: The favourable effects of agomelatine on sleep quality and the rapid onset of this effect may be beneficial in particular cases. Agomelatine may be an alternative drug for patients who complain of sexual side effects. Clinicians should evaluate the lipid profile of patients using sertraline, while liver function should be monitored in patients using agomelatine. Neither treatment led to unfavourable outcomes on most of the metabolic parameters.
C1 [Talas, Anil] Tuzla State Hosp, Psychiat Clin, Istanbul, Turkey.
   [Cerit, Cem] Kocaeli Univ, Sch Med, Dept Psychiat, TR-41000 Kocaeli, Umuttepe, Turkey.
   [Aslan, Esma Akpinar] Gaziosmanpasa Univ, Sch Med, Dept Psychiat, Tokat, Turkey.
C3 University of Tuzla; Tuzla State Hospital; Kocaeli University; Tokat
   Gaziosmanpasa University
RP Cerit, C (corresponding author), Kocaeli Univ, Sch Med, Dept Psychiat, TR-41000 Kocaeli, Umuttepe, Turkey.
EM cemcerit@yahoo.com
RI cerit, cem/G-6949-2018
OI AKPINAR ASLAN, ESMA/0000-0003-4714-6894
CR Akpinar E, 2016, CLIN PSYCHOPHARM NEU, V14, P351, DOI 10.9758/cpn.2016.14.4.351
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NR 32
TC 4
Z9 4
U1 0
U2 6
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 2475-0573
EI 2475-0581
J9 PSYCHIAT CLIN PSYCH
JI Psychiatry Clin. Psychopharmacol.
PD JUL 3
PY 2019
VL 29
IS 3
BP 257
EP 263
DI 10.1080/24750573.2018.1490096
PG 7
WC Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Psychiatry
GA IS0IK
UT WOS:000481832500004
OA gold
DA 2025-06-11
ER

PT J
AU Klinge, I
AF Klinge, Ineke
TI Gender perspectives in European research
SO PHARMACOLOGICAL RESEARCH
LA English
DT Review
DE Sex differences; Gender effects; Basic and clinical research; Research
   methodology; EU gender equality policy; Gender sensitive research;
   Practical tools
ID SEX-DIFFERENCES; LIFE SCIENCES
AB Background: Attention to sex and gender aspects in biomedical and health-related research has been a major initiative of the EU gender equality policy for research. The EU funded GenderBasic project (2005-2008), conceived to stimulate this attention to sex and gender and to provide practical tools to researchers, resulted in the publication of 10 reviews by high-level scientists in a Supplement to Gender Medicine in December 2007: "Bringing Gender Expertise to Biomedical and Health-Related Research".
   Methods: Four commissioned reviews covered methodological aspects of addressing sex and gender in biomedical research - ranging from basic, molecular to public health research - next to six reviews that addressed sex and gender aspects relevant to selected health areas: anxiety disorders, asthma, metabolic syndrome, nutrigenomics, osteoporosis and work-related health.
   Results: The review articles, that were discussed at an expert meeting, attended - upon invitation - by a mixed audience of basic and clinical researchers, epidemiologists, social scientists and gender researchers, came up with excellent state of the art data, solutions to methodological and conceptual problems, practical tools and interesting questions for further research.
   Conclusion: The expert meeting created great enthusiasm among the participants and a real exchange took place among researchers from various backgrounds. Most life sciences researchers were familiar with the concept of sex differences but confessed that the effects of socially constructed gender until now, had received too little attention.
   The GenderBasic project yielded three major achievements for European research: (1) it stimulated and promoted research into sex differences; (2) it stimulated research into the workings of gender, illustrated by useful examples in particular in understanding masculinity and its effects on the health of individual men; (3) it highlighted sex-gender interaction and granted gender a prominent place on the research agenda that resulted from GenderBasic. A final conclusion of the project was that it is not differences per se that are interesting but rather how, as a result of the interaction between sex and gender, differences develop.
   The European Commission selected the GenderBasic project itself as an excellent example of the positive impacts EU research can achieve and the project will be featured in a catalogue of 6th Framework Success Stories. (c) 2008 Elsevier Ltd. All rights reserved.
C1 [Klinge, Ineke] Maastricht Univ, Fac Hlth Med & Life Sci, Sch Publ Hlth & Primary Care Caphri, FHML HES, NL-6200 MD Maastricht, Netherlands.
   [Klinge, Ineke] Maastricht Univ, Ctr Gender & Divers, FHML HES, NL-6200 MD Maastricht, Netherlands.
C3 Maastricht University; Maastricht University
RP Klinge, I (corresponding author), Univ Med Gottingen, Abt Eth & Geschichte Med, Humboldtallee 36, D-37073 Gottingen, Germany.
EM i.klinge@hes.unimaas.nl
CR [Anonymous], 2000, HLTH CAN GEND BAS AN
   [Anonymous], J WOMENS HLTH GENDER
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NR 39
TC 33
Z9 34
U1 2
U2 18
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 1043-6618
J9 PHARMACOL RES
JI Pharmacol. Res.
PD SEP-OCT
PY 2008
VL 58
IS 3-4
BP 183
EP 189
DI 10.1016/j.phrs.2008.07.011
PG 7
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 375RT
UT WOS:000261131700002
PM 18761409
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Yang, M
   Chen, XY
   Shen, QH
   Xiong, Z
   Liu, TJ
   Leng, Y
   Jiao, Y
AF Yang, Ming
   Chen, Xingyu
   Shen, Qiaohui
   Xiong, Zhuang
   Liu, Tiejun
   Leng, Yan
   Jiao, Yue
TI Development and validation of a predictive nomogram for the risk of
   MAFLD in postmenopausal women
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Article
DE MAFLD; postmenopausal women; nomogram; predictive model; risk factors
ID FATTY LIVER-DISEASE; METABOLIC SYNDROME; HEPATOCELLULAR-CARCINOMA;
   ASSOCIATION; HEALTH; PREVALENCE; DIAGNOSIS; MEAT
AB Background and aim Metabolic-associated fatty liver disease (MAFLD) has gradually become one of the main health concerns regarding liver diseases. Postmenopausal women represent a high-risk group for MAFLD; therefore, it is of great importance to identify and intervene with patients at risk at an early stage. This study established a predictive nomogram model of MAFLD in postmenopausal women and to enhance the clinical utility of the new model, the researchers limited variables to simple clinical and laboratory indicators that are readily obtainable.Methods Data of 942 postmenopausal women from January 2023 to October 2023 were retrospectively collected and divided into two groups according to the collection time: the training group (676 cases) and the validation group (226 cases). Significant indicators independently related to MAFLD were identified through univariate logistic regression and stepwise regression, and the MAFLD prediction nomogram was established. The C-index and calibration curve were used to quantify the nomogram performance, and the model was evaluated by measuring the area under the receiver operating characteristic curve (AUC), calibration curve, and decision curve analysis (DCA).Results Of 37 variables, 11 predictors were identified, including occupation (worker), body mass index, waist-to-hip ratio, number of abortions, anxiety, hypertension, hyperlipidemia, diabetes, hyperuricemia, and diet (meat and processed meat). The C-index of the training group predicting the related risk factors was 0.827 (95% confidence interval [CI] 0.794-0.860). The C-index of the validation group was 0.787 (95% CI 0.728-0.846). Calibration curves 1 and 2 (BS1000 times) were close to the diagonal, showing a good agreement between the predicted probability and the actual incidence in the two groups. The AUC of the training group was 0.827, the sensitivity was 0.784, and the specificity was 0.735. The AUC of the validation group was 0.787, the sensitivity was 0.674, and the specificity was 0.772. The DCA curve showed that the nomogram had a good net benefit in predicting MAFLD in postmenopausal women.Conclusions A predictive nomogram for MAFLD in postmenopausal women was established and verified, which can assist clinicians in evaluating the risk of MAFLD at an early stage.
C1 [Yang, Ming; Shen, Qiaohui; Liu, Tiejun; Leng, Yan] Changchun Univ Chinese Med, Coll Tradit Chinese Med, Changchun, Peoples R China.
   [Yang, Ming; Chen, Xingyu; Xiong, Zhuang; Liu, Tiejun; Leng, Yan] Changchun Univ Chinese Med, Affiliated Hosp 1, Dept Liver Spleen & Gastroenterol, Changchun, Peoples R China.
   [Jiao, Yue] Changchun Tongyuan Hosp, Dept Intens Care Unit, Changchun, Peoples R China.
C3 Changchun University of Chinese Medicine; Changchun University of
   Chinese Medicine
RP Leng, Y (corresponding author), Changchun Univ Chinese Med, Coll Tradit Chinese Med, Changchun, Peoples R China.; Leng, Y (corresponding author), Changchun Univ Chinese Med, Affiliated Hosp 1, Dept Liver Spleen & Gastroenterol, Changchun, Peoples R China.; Jiao, Y (corresponding author), Changchun Tongyuan Hosp, Dept Intens Care Unit, Changchun, Peoples R China.
EM lengyan229@163.com; jiaoyue0916@163.com
RI Yang, Ying/K-7218-2017; 陈, 星宇/ISR-9471-2023
FU Natural Science Foundation of Jilin Province [YDZJ202201ZYTS263];
   Science and Technology capability enhancement Project of Jilin
   Provincial Health Commission [2023LC034]
FX Authors thank the investigators from Changchun University of Chinese
   Medicine.
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NR 36
TC 0
Z9 0
U1 1
U2 4
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD AUG 6
PY 2024
VL 15
AR 1334924
DI 10.3389/fendo.2024.1334924
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA D1H2X
UT WOS:001293760100001
PM 39165508
OA gold
DA 2025-06-11
ER

PT J
AU Monterrosa, A
   Blumel, JE
   Chedraui, P
AF Monterrosa, Alvaro
   Blumel, Juan E.
   Chedraui, Peter
TI Increased menopausal symptoms among Afro-Colombian women as assessed
   with the Menopause Rating Scale
SO MATURITAS
LA English
DT Article
DE menopause; black race; Colombia; menopausal symptoms; Menopause Rating
   Scale
ID QUALITY-OF-LIFE; LATE REPRODUCTIVE YEARS; CLIMACTERIC SYMPTOMS; HOT
   FLASHES; METABOLIC SYNDROME; RISK-FACTORS; RACIAL-DIFFERENCES;
   AFRICAN-AMERICAN; HORMONE LEVELS; MIDLIFE WOMEN
AB Background: Increased frequency and severity of menopausal symptoms have been associated to black race. However, this situation has not been described in any Latin American population.
   Objective: Compare frequency and severity of menopausal symptoms among Afro and non-Afro Hispanic Colombian climacteric women.
   Methods: In this cross-sectional study, healthy Afro and non-Afro-Colombian women aged 40-59 years were asked to fill out the Menopause Rating Scale (MRS) questionnaire in order to compare symptom frequency and intensity.
   Results: A total of 578 women were surveyed (201 Afro-Colombian and 377 non-Afro-Colombian). Mean age of the whole sample was 47.9 +/- 5.9 years (median 47), with no differences among studied groups in terms of age, parity, and hormone therapy (HT) use. Intensity of menopausal symptoms, assessed with the total MRS score, was found to be significantly higher among Afro-Colombian women (10.6 +/- 6.7 vs. 7.5 +/- 5.7, p = 0.0001), which was due to higher somatic and psychological subscale scores. In this group, the frequency of somatic symptoms, heart discomfort and muscle and joint problems, was found to be higher than in non-Afro-Colombian women (38.8% vs. 26.8% and 77.1% vs. 43.5%, respectively, p < 0.05); equally, all items of the psychological subscale (depressive mood, irritability, anxiety and physical exhaustion) were also found to be higher among black women. On the other hand, compared to black women non-Afro-Colombian ones presented more bladder problems (24.9% vs. 14.9%, p=0.005). After adjusting for confounding factors, logistic regression analysis determined that black race increased the risk for presenting higher total MRS scorings (OR: 2.31; CI 95%: 1.55-3.45, P=0.0001).
   Conclusion: Despite the limitations of this study, as determined with the MRS Afro-Colombian women exhibited more impaired quality of life (QoL) when compared to non-Afro-Colombian ones, due to a higher rate and severity of menopausal somatic and psychological symptoms. (c) 2007 Elsevier Ireland Ltd. All rights reserved.
C1 [Chedraui, Peter] Univ Catolica Santiago Guayaquil, Inst Biomed, Fac Ciencias Med, Guayaquil, Ecuador.
   [Monterrosa, Alvaro] Univ Cartagena, Fac Med, Dept Gynecol & Obstet, Cartagena, Colombia.
   [Blumel, Juan E.] Univ Chile, Dept Med Sur, Fac Med, Hosp Barros Luco Trudeau, Santiago, Chile.
C3 Universidad de Cartagena; Universidad de Chile
RP Chedraui, P (corresponding author), Univ Catolica Santiago Guayaquil, Inst Biomed, Fac Ciencias Med, Av CJ Arosemena Km 1-5,POB 09-01-4671, Guayaquil, Ecuador.
EM peterchedraui@yahoo.com
RI Blümel, Juan Enrique/JUV-6950-2023
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NR 42
TC 35
Z9 45
U1 0
U2 3
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0378-5122
J9 MATURITAS
JI Maturitas
PD FEB
PY 2008
VL 59
IS 2
BP 182
EP 190
DI 10.1016/j.maturitas.2007.12.002
PG 9
WC Geriatrics & Gerontology; Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology; Obstetrics & Gynecology
GA 287TI
UT WOS:000254939000009
PM 18234460
DA 2025-06-11
ER

PT J
AU Pacher, P
   Bátkai, S
   Kunos, G
AF Pacher, Pal
   Batkai, Sandor
   Kunos, George
TI The endocannabinoid system as an emerging target of pharmacotherapy
SO PHARMACOLOGICAL REVIEWS
LA English
DT Review
ID CANNABINOID CB1 RECEPTOR; ACID AMIDE HYDROLASE; MESSENGER-RNA LEVELS;
   CLOSED-HEAD INJURY; NECROSIS-FACTOR-ALPHA; EXPERIMENTAL AUTOIMMUNE
   ENCEPHALOMYELITIS; CONDITIONED PLACE PREFERENCE; LEVODOPA-INDUCED
   DYSKINESIA; TRAUMATIC BRAIN-INJURY; AGONIST WIN 55,212-2
AB The recent identification of cannabinoid receptors and their endogenous lipid ligands has triggered an exponential growth of studies exploring the endocannabinoid system and its regulatory functions in health and disease. Such studies have been greatly facilitated by the introduction of selective cannabinoid receptor antagonists and inhibitors of endocannabinoid metabolism and transport, as well as mice deficient in cannabinoid receptors or the endocannabinoid-degrading enzyme fatty acid amidohydrolase. In the past decade, the endocannabinoid system has been implicated in a growing number of physiological functions, both in the central and peripheral nervous systems and in peripheral organs. More importantly, modulating the activity of the endocannabinoid system turned out to hold therapeutic promise in a wide range of disparate diseases and pathological conditions, ranging from mood and anxiety disorders, movement disorders such as Parkinson's and Huntington's disease, neuropathic pain, multiple sclerosis and spinal cord injury, to cancer, atherosclerosis, myocardial infarction, stroke, hypertension, glaucoma, obesity/metabolic syndrome, and osteoporosis, to name just a few. An impediment to the development of cannabinoid medications has been the socially unacceptable psychoactive properties of plant-derived or synthetic agonists, mediated by CB1 receptors. However, this problem does not arise when the therapeutic aim is achieved by treatment with a CB1 receptor antagonist, such as in obesity, and may also be absent when the action of endocannabinoids is enhanced indirectly through blocking their metabolism or transport. The use of selective CB2 receptor agonists, which lack psychoactive properties, could represent another promising avenue for certain conditions. The abuse potential of plant-derived cannabinoids may also be limited through the use of preparations with controlled composition and the careful selection of dose and route of administration. The growing number of preclinical studies and clinical trials with compounds that modulate the endocannabinoid system will probably result in novel therapeutic approaches in a number of diseases for which current treatments do not fully address the patients' need. Here, we provide a comprehensive overview on the current state of knowledge of the endocannabinoid system as a target of pharmacotherapy.
C1 NIAAA, NIH, Lab Physiol Studies, Bethesda, MD 20892 USA.
C3 National Institutes of Health (NIH) - USA; NIH National Institute on
   Alcohol Abuse & Alcoholism (NIAAA)
RP Kunos, G (corresponding author), NIAAA, NIH, Lab Physiol Studies, 5625 Fishers Lane,Room 2S-24, Bethesda, MD 20892 USA.
EM gkunos@mail.nih.gov
RI Bátkai, Sándor/H-7983-2014; Pacher, Pal/B-6378-2008
OI Pacher, Pal/0000-0001-7036-8108
FU Intramural NIH HHS [Z01 AA000375] Funding Source: Medline
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NR 1332
TC 1617
Z9 1858
U1 12
U2 399
PU AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3995 USA
SN 0031-6997
EI 1521-0081
J9 PHARMACOL REV
JI Pharmacol. Rev.
PD SEP
PY 2006
VL 58
IS 3
BP 389
EP 462
DI 10.1124/pr.58.3.2
PG 74
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 083NW
UT WOS:000240465500004
PM 16968947
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Llorca, PM
   Lançon, C
   Hartry, A
   Brown, TM
   DiBenedetti, DB
   Kamat, SA
   François, C
AF Llorca, Pierre-Michel
   Lancon, Christophe
   Hartry, Ann
   Brown, T. Michelle
   DiBenedetti, Dana B.
   Kamat, Siddhesh A.
   Francois, Clement
TI Assessing the burden of treatment-emergent adverse events associated
   with atypical antipsychotic medications
SO BMC PSYCHIATRY
LA English
DT Article
DE Schizophrenia; Major depressive disorder; Atypical antipsychotics;
   Treatment-emergent adverse events
ID EVIDENCE-BASED GUIDELINES; 2ND-GENERATION ANTIPSYCHOTICS; BRITISH
   ASSOCIATION; SCHIZOPHRENIA; TOLERABILITY; EFFICACY; DISORDERS; ATTITUDE;
   DRUGS
AB Background: Treatment of schizophrenia and major depressive disorder (MDD) with atypical antipsychotics (AAPs) show improved efficacy and reduced side effect burden compared with older antipsychotic medications. However, a risk of treatment-emergent adverse events (TEAEs) remains. TEAEs are hard to quantify and perspectives on the importance of TEAEs differ across patients and between patients and physicians. The current study is a qualitative assessment that investigates TEAEs of AAPs from both patient and physician perspectives to provide better understanding of the occurrence and burden of TEAEs associated with these medications.
   Methods: Focus groups comprised of patients with MDD and interviews with patients with schizophrenia were conducted at two qualitative research facilities, along with a physician focus group at one of the facilities. Information collected from patients included an exhaustive list of TEAEs experienced, and the frequency and level of bother of each TEAE; from psychiatrists, information included an exhaustive list of TEAEs based on personal observations and patient report, frequency of TEAEs, clinically important TEAEs, and levels of patient-perceived bother. Standard qualitative analysis methods were used to identify, quantify, characterize, and summarize patterns found in the data collected.
   Results: A total of 42 patients (25 with MDD and 17 with schizophrenia) and 4 psychiatrists participated in the study. TEAEs reported as bothersome across both patients groups included cognitive issues, weight gain and/or increased appetite, low energy, extrapyramidal symptoms (EPS), and need to sleep/excessive sleep/excessive sleepiness. TEAEs considered more bothersome by patients with schizophrenia were weight gain, low energy, EPS, mental anxiety, and increased positive symptoms; those considered more bothersome by patients with MDD were cognitive issues, somnolence/sedation, and flat/restricted affect. TEAEs considered most clinically important by psychiatrists included metabolic syndrome, weight gain, neutropenia, hyperglycemia, and QT prolongation; those TEAEs considered most bothersome to patients from physicians' perspectives included weight gain, reduced sexual desire or performance, EPS, akathisia, and hormonal issues.
   Conclusions: The wide range of TEAEs that are both frequent and bothersome and the variation in perceived burden according to diagnosis highlight the need for a tailored TEAE-awareness approach when choosing an AAP.
C1 [Llorca, Pierre-Michel] Univ Clermont Auvergne, CMP B CHU Clermont Ferrand, Clermont Ferrand 1, France.
   [Lancon, Christophe] Univ Mediterranee, Lab Sante Publ Evaluat Syst Soins & Sante Percue, Marseille 5, France.
   [Hartry, Ann; Francois, Clement] Lundbeck, Deerfield, IL 60015 USA.
   [Brown, T. Michelle; DiBenedetti, Dana B.] RTI Hlth Solut, Charlotte, NC USA.
   [Kamat, Siddhesh A.] Otsuka Pharmaceut Dev Corp, Princeton, NJ USA.
C3 Universite Clermont Auvergne (UCA); CHU Clermont Ferrand; Aix-Marseille
   Universite; Research Triangle Institute
RP Hartry, A (corresponding author), Lundbeck, Deerfield, IL 60015 USA.
EM AHRY@lundbeck.com
RI Fond, Guillaume/D-7646-2011; François, Clément/AAR-3163-2021
OI Brown, T. Michelle/0000-0002-4580-805X; DiBenedetti,
   Dana/0000-0003-2294-9519; Francois, Clement/0000-0003-2278-3352
FU Otsuka America Pharmaceutical, Inc., Princeton, NJ, USA; Otsuka
   Pharmaceutical Development and Commercialization, Inc., Princeton, NJ,
   USA; Lundbeck LLC, Copenhagen, Denmark
FX This study was sponsored by Otsuka America Pharmaceutical, Inc.,
   Princeton, NJ, USA, Otsuka Pharmaceutical Development and
   Commercialization, Inc., Princeton, NJ, USA, and Lundbeck LLC,
   Copenhagen, Denmark.
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NR 28
TC 21
Z9 21
U1 1
U2 10
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1471-244X
J9 BMC PSYCHIATRY
JI BMC Psychiatry
PD FEB 13
PY 2017
VL 17
AR 67
DI 10.1186/s12888-017-1213-6
PG 11
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychiatry
GA EL7SK
UT WOS:000394820700001
PM 28193195
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Balestra, F
   De Luca, M
   Panzetta, G
   Palieri, R
   Shahini, E
   Giannelli, G
   De Pergola, G
   Scavo, MP
AF Balestra, Francesco
   De Luca, Maria
   Panzetta, Giorgia
   Palieri, Rita
   Shahini, Endrit
   Giannelli, Gianluigi
   De Pergola, Giovanni
   Scavo, Maria Principia
TI Advancing Obesity Management: the Very Low-Energy Ketogenic therapy
   (VLEKT) as an Evolution of the "Traditional" Ketogenic Diet
SO CURRENT OBESITY REPORTS
LA English
DT Review
DE Ketogenic diet (KD); Very low calorie ketogenic diet (VLCKD); Very
   low-energy ketogenic therapy (VLEKT); Obesity metabolism; MASLD; Obesity
ID ADIPOSE-TISSUE; WEIGHT-LOSS; DISORDERS; INSIGHTS; HISTORY; STRESS;
   HEALTH; ADULTS
AB Purpose of Review This narrative review comprehensively analyzes VLEKT as an advanced nutritional strategy for obesity management. The focus is on the beneficial effects on key disease organs, such as adipose tissue and liver, as well as the modulation of intestinal permeability and its fundamental role in influencing the gut microbiota and inflammatory pathways. Recent Findings The impact of VLEKT on obesity-related comorbidities, including metabolic syndrome, cardiovascular disease, endocrine disorders, metabolic dysfunction-associated steatotic liver disease (MASLD), neurological disorders, and kidney alterations, is also investigated. Moreover, to assess its wider application in obesity treatment, the combination of ketogenic regimes with additional strategies such as physical activity, bariatric surgery, and digital health technologies is examined. Despite promising clinical results, adherence to VLEKT and potential nutritional deficiencies require careful follow-up and individualized programming monitored by specialists. Future research should focus on elucidating the molecular mechanisms underlying the effects on physiological systems, and long-term safety. Nevertheless, VLEKT is an innovative approach to obesity treatment, offering a target-oriented and highly effective strategy for people fighting against overweight and its associated medical complications. Summary Obesity is a multifactorial and chronic disease associated with numerous comorbidities; given its increasing prevalence, effective and personalized intervention strategies are crucial to inhibit the "obesity pandemic" according to a "food re-educational" protocol. Among dietary interventions, the ketogenic diet (KD) has attracted attention for its effectiveness in weight management and metabolic benefits. A variant, the very low-calorie ketogenic diet (VLCKD), more recently defined as very low-energy ketogenic diet (VLEKD), combines the metabolic benefits of ketosis with substantial calorie restriction, improving overall health.
C1 [Balestra, Francesco; De Luca, Maria; Panzetta, Giorgia; Palieri, Rita; Scavo, Maria Principia] Natl Inst Gastroenterol IRCCS S Bellis, Lab Mol Med, Via Turi 27, I-70013 Castellana Grotte, Bari, Italy.
   [Shahini, Endrit] Natl Inst Gastroenterol IRCCS S Bellis, Gastroenterol Unit, Via Turi 27, I-70013 Castellana Grotte, Bari, Italy.
   [Giannelli, Gianluigi] Natl Inst Gastroenterol IRCCS De Bellis, Sci Direct, Via Turi 27, I-70013 Castellana Grotte, BA, Italy.
   [De Pergola, Giovanni] Natl Inst Gastroenterol IRCCS Saverio Bellis, Ctr Nutr Res & Care Obes & Metab Dis, Via Turi 27, I-70013 Castellana Grotte, Bari, Italy.
RP Scavo, MP (corresponding author), Natl Inst Gastroenterol IRCCS S Bellis, Lab Mol Med, Via Turi 27, I-70013 Castellana Grotte, Bari, Italy.
EM francesco.balestra@irccsdebellis.it; maria.deluca@irccsdebellis.it;
   giorgia.panzetta@irccsdebellis.it; rita.palieri@irccsdebellis.it;
   endrit.shahini@irccsdebellis.it; gianluigi.giannelli@irccsdebellis.it;
   giovanni.depergola@irccsdebellis.it; maria.scavo@irccsdebellis.it
RI Balestra, Francesco/MBW-1608-2025; Scavo, Maria/AAR-6713-2020; Palieri,
   Rita/MCX-9447-2025; Panzetta, Giorgia/MCI-7248-2025
FU Italian Ministry of Heath [RC2025]
FX This study was funded by Italian Ministry of Heath, grant number: RC2025
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NR 179
TC 0
Z9 0
U1 4
U2 4
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 2162-4968
J9 CURR OBES REP
JI Curr. Obes. Rep.
PD APR 3
PY 2025
VL 14
IS 1
AR 30
DI 10.1007/s13679-025-00622-2
PG 20
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 0XI0D
UT WOS:001458239800001
PM 40175850
OA hybrid, Green Accepted
DA 2025-06-11
ER

PT J
AU Miura, K
   Hasumura, M
   Kitahara, Y
   Nishitani, S
   Yamada, Y
AF Miura, Kyoko
   Hasumura, Mai
   Kitahara, Yoshiro
   Nishitani, Shinobu
   Yamada, Yoji
TI A novel amino acid mixture containing isoleucine, glycine, and cystine
   improves insulin sensitivity with restoring mitochondrial oxygen
   consumption in C2C12 myotubes
SO FUNCTIONAL FOODS IN HEALTH AND DISEASE
LA English
DT Article
DE Insulin sensitivity; Mitochondrial function; Amino acid mixtures;
   Isoleucine; Glycine; Cystine
ID SKELETAL-MUSCLE; GLUCOSE-UPTAKE; PALMITATE; METABOLISM; RESISTANCE;
   PHOSPHORYLATION; EXERCISE; LEUCINE; STRESS
AB Background: Saturated fatty acids facilitate insulin insensitivity within peripheral tissues, which have been linked to the development of metabolic syndrome. Although some amino acids are involved in regulating lipid metabolism, their effect on insulin sensitivity remains unclear. This study investigated the effect of amino acids on restoring FFA-induced insulin insensitivity using C2C12 skeletal muscle cells. Methods: C2C12 myotubes were treated with 0.5 mM palmitate overnight. Then, 1 mM of each amino acid was added, and the cells were incubated for an additional 18 hours. Akt phosphorylation was assessed with a western blot after stimulation with 100 nM insulin. Under the same conditions, glucose uptake was measured using a glucose uptake assay kit. Mitochondrial function was measured using an extracellular flux analyzer. Results: Palmitate treatment reduced Akt phosphorylation to 40% of the control levels. However, among 17 amino acids evaluated, isoleucine (I), glycine (G), and cystine (C) restored Akt phosphorylation successfully. Under the same conditions, glucose uptake was reduced by palmitate. A mixture of I, G, and C (IGC) was found to restore glucose uptake. In addition, palmitate decreased oxygen consumption and ATP production in C2C12 mitochondria, as determined by the Seahorse system, which is an extracellular flux analyzer. IGC was also found to restore mitochondrial function. Conclusions: The data collected in this study suggest that an appropriate amino acid mixture consisting of I, G and C may restore insulin signaling and glucose utilization suppressed by FFA. This was also found to restore mitochondrial oxygen consumption. Novelty: This study uniquely demonstrates that a novel amino acid mixture-comprising isoleucine, glycine, and cystine (IGC)-effectively restores insulin sensitivity and mitochondrial oxygen consumption in palmitate-induced insulin-resistant C2C12 myotubes. This conclusion could be used to identify a potential therapeutic strategy for metabolic dysfunction.
C1 [Miura, Kyoko; Hasumura, Mai; Kitahara, Yoshiro; Nishitani, Shinobu; Yamada, Yoji] Ajinomoto Co INC, Inst Food Sci & technol, Food Prod Div, Wellness Solut Dev Ctr, 1-1 Suzuki Cho,Kawasaki Ku, Kawasaki, Kanagawa 2108681, Japan.
C3 Ajinomoto Co Inc
RP Miura, K (corresponding author), Ajinomoto Co INC, Inst Food Sci & technol, Food Prod Div, Wellness Solut Dev Ctr, 1-1 Suzuki Cho,Kawasaki Ku, Kawasaki, Kanagawa 2108681, Japan.
CR Abdul-Ghani MA, 2010, J BIOMED BIOTECHNOL, DOI 10.1155/2010/476279
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NR 49
TC 0
Z9 0
U1 0
U2 0
PU FUNCTIONAL FOOD CENTER INC
PI DALLAS
PA 5050 QUORUM DR, STE 700,  NO 338, DALLAS, TX 75254 USA
SN 2160-3855
J9 FUNCT FOODS HEALTH D
JI Funct. Foods Health Dis.
PD APR
PY 2025
VL 15
IS 4
BP 205
EP 216
DI 10.31989/ffhd.v15i4.1582
PG 12
WC Food Science & Technology
WE Emerging Sources Citation Index (ESCI)
SC Food Science & Technology
GA 1OC5R
UT WOS:001469631100001
OA gold
DA 2025-06-11
ER

PT J
AU Maeda, K
   Yamada, H
   Munetsuna, E
   Fujii, R
   Yamazaki, M
   Ando, Y
   Mizuno, G
   Tsuboi, Y
   Ishikawa, H
   Ohashi, K
   Hashimoto, S
   Hamajima, N
   Suzuki, K
AF Maeda, Keisuke
   Yamada, Hiroya
   Munetsuna, Eiji
   Fujii, Ryosuke
   Yamazaki, Mirai
   Ando, Yoshitaka
   Mizuno, Genki
   Tsuboi, Yoshiki
   Ishikawa, Hiroaki
   Ohashi, Koji
   Hashimoto, Shuji
   Hamajima, Nobuyuki
   Suzuki, Koji
TI Serum carotenoid levels are positively associated with DNA methylation
   of thioredoxin-interacting protein
SO INTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCH
LA English
DT Article
DE DNA methylation; Thioredoxin-interacting protein; carotenoid; Yakumo
   study
ID EPIGENOME-WIDE ASSOCIATION; BETA-CAROTENE; PLASMA CAROTENOIDS; METABOLIC
   SYNDROME; DIABETES-MELLITUS; OXIDATIVE STRESS; RISK; DISEASE; CANCER;
   FRUIT
AB Background: Carotenoids have been reported to exert protective effects against age-related diseases via changes in DNA methylation. Although lower thioredoxin-interacting protein (TXNIP) DNA methylation is associated with age-related diseases, only a few studies have investigated the factors influencing TXNIP DNA methylation. Carotenoids may be a factor linking TXNIP to specific pathophysiological functions. The aim of this study was to examine whether serum carotenoid levels are associated with TXNIP DNA methylation levels. Methods: We conducted a cross-sectional study using 376 health examination participants (169 men). DNA methylation levels were determined using a pyrosequencing assay. Serum carotenoid levels were determined by high-performance liquid chromatography. Multivariable regression analyses were performed to examine the associations between TXNIP DNA methylation levels and serum carotenoid levels with adjustment for age, BMI, HbA1c, CRP, smoking habits, alcohol consumption, exercise habits, and percentage of neutrophils. Results: Multiple linear regression analyses showed that TXNIP DNA methylation levels were positively associated with serum levels of zeaxanthin/lutein (beta [95%CI]: 1.935 [0.184, 3.685]), beta-cryptoxanthin (1.447 [0.324, 2.570]), alpha-carotene (1.061 [0.044, 2.077]), beta-carotene (1.272 [0.319, 2.226]), total carotenes (1.255 [0.040, 2.469]), total xanthophylls (2.133 [0.315, 3.951]), provitamin A (1.460 [0.402, 2.519]), and total carotenoids (1.972 [0.261, 3.683]) in men (all p<0.05). Of these, provitamin A showed the stronger association (standardized beta=0.216). No significant association of TXNIP DNA methylation and serum carotenoid was observed in women. Conclusions: The findings of this study suggest that carotenoid intake may protect against age-related diseases by altering TXNIP DNA methylation status in men.
C1 [Maeda, Keisuke] Fujita Hlth Univ, Dept Clin Physiol, Sch Med Sci, Toyoake, Japan.
   [Yamada, Hiroya; Hashimoto, Shuji] Fujita Hlth Univ, Dept Hyg, Sch Med, Toyoake, Japan.
   [Munetsuna, Eiji] Fujita Hlth Univ, Dept Biochem, Sch Med, Toyoake, Japan.
   [Fujii, Ryosuke; Tsuboi, Yoshiki; Suzuki, Koji] Fujita Hlth Univ, Dept Prevent Med Sci, Sch Med Sci, Toyoake, Japan.
   [Fujii, Ryosuke] Univ Lubeck, Inst Biomed, Eurac Res, Bolzano, Italy.
   [Yamazaki, Mirai] Kagawa Prefectural Univ Hlth Sci, Dept Med Technol, Takamatsu, Japan.
   [Ando, Yoshitaka; Ishikawa, Hiroaki; Ohashi, Koji] Fujita Hlth Univ, Dept Informat Clin Med, Sch Med Sci, Toyoake, Japan.
   [Mizuno, Genki] Tokyo Univ Technol, Sch Hlth Sci, Dept Med Technol, Tokyo, Japan.
   [Hamajima, Nobuyuki] Nagoya Univ, Dept Healthcare Adm, Grad Sch Med, Nagoya, Japan.
   [Suzuki, Koji] Fujita Hlth Univ, Dept Prevent Med Sci, Sch Med Sci, 1-98 Dengakugakubo,Kutsukake Cho, Toyoake 4701192, Japan.
C3 Fujita Health University; Fujita Health University; Fujita Health
   University; Fujita Health University; European Academy of Bozen-Bolzano;
   Fujita Health University; Tokyo University of Technology; Nagoya
   University; Fujita Health University
RP Suzuki, K (corresponding author), Fujita Hlth Univ, Dept Prevent Med Sci, Sch Med Sci, 1-98 Dengakugakubo,Kutsukake Cho, Toyoake 4701192, Japan.
EM ksuzuki@fujita-hu.ac.jp
RI Ando, Yasuhiro/D-6371-2012; Maeda, Keisuke/KCY-9229-2024
OI Maeda, Keisuke/0000-0001-8916-2687; Fujii, Ryosuke/0000-0003-1730-2059;
   Ando, Yoshitaka/0000-0002-1213-8096; Tsuboi, Yoshiki/0000-0001-8145-3949
FU We are grateful to the municipal officers and volunteer staff of the
   Health Examination Program for Residents of Yakumo, Hokkaido, Japan.;
   Health Examination Program for Residents of Yakumo, Hokkaido, Japan
FX We are grateful to the municipal officers and volunteer staff of the
   Health Examination Program for Residents of Yakumo, Hokkaido, Japan.
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NR 55
TC 2
Z9 2
U1 1
U2 2
PU IMR PRESS
PI ROBINSON
PA 112 ROBINSON RD, ROBINSON, SINGAPORE
SN 0300-9831
EI 1664-2821
J9 INT J VITAM NUTR RES
JI Int. J. Vitam. Nutr. Res.
PD JUN
PY 2024
VL 94
IS 3-4
BP 210
EP 220
DI 10.1024/0300-9831/a000791
EA SEP 2023
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA UA0Q6
UT WOS:001069564200001
PM 37735933
DA 2025-06-11
ER

PT J
AU Khodarahmi, M
   Foroumandi, E
   Jafarabadi, MA
AF Khodarahmi, Mahdieh
   Foroumandi, Elaheh
   Jafarabadi, Mohammad Asghari
TI Effects of soy intake on circulating levels of TNF-α and interleukin-6:
   a systematic review and meta-analysis of randomized controlled trials
SO EUROPEAN JOURNAL OF NUTRITION
LA English
DT Review
DE Soy; Inflammation; Interleukin-6; TNF-&#945; Isoflavone; Meta-analysis
ID C-REACTIVE PROTEIN; EQUOL PRODUCER PHENOTYPE; HIGH-DOSE ISOFLAVONES;
   POSTMENOPAUSAL WOMEN; METABOLIC SYNDROME; INFLAMMATORY MARKERS;
   ENDOTHELIAL FUNCTION; SOYBEAN ISOFLAVONES; ADHESION MOLECULES; OXIDATIVE
   STRESS
AB Purpose Pro-inflammatory mediators, including serum tumor necrosis factor alpha (TNF-alpha) and interleukin-6 (IL-6), can be used as biomarkers to indicate or monitor disease. This study was designed to ascertain the effects of soy products on TNF-alpha and IL-6 levels. Methods PubMed, EMBASE, Science Direct, Web of Science, Google Scholar and the Cochrane Central Register of Controlled Trials were searched to November 2019 for RCTs around the effects of soy-based products on TNF-alpha and IL-6. A random effects model was used to calculate overall effect size. Results In total, 29 eligible publications were considered in the present systematic review, of which 25 were included in this meta-analysis. The overall effect of soy products on TNF-alpha and IL-6 levels failed to reach statistical significance (MD = - 0.07; 95% CI - 0.22-0.09; I-2 50.9; MD = 0.03; 95% CI - 0.07-0.14; I-2 42.1, respectively). According to a subgroup analysis, natural soy products led to a reduction in TNF-alpha concentration compared with processed soy products (MD = - 0.32; 95% CI - 0.45 to - 0.19; I-2 0.0). Moreover, IL-6 reduction was stronger in participants who were affected by different diseases (MD = - 0.04; 95% CI - 0.07 to - 0.02; I-2 0.0). Conclusions A review of RCTs published to November 2019 found that natural soy products are effective in lowering TNF-alpha levels. While the beneficial effects on reduction of IL-6 appeared stronger in individuals affected by different diseases, this finding cannot be generalized to all individuals affected by different diseases.
C1 [Khodarahmi, Mahdieh; Foroumandi, Elaheh] Tabriz Univ Med Sci, Fac Nutr & Food Sci, Nutr Res Ctr, Tabriz, Iran.
   [Khodarahmi, Mahdieh; Foroumandi, Elaheh] Tabriz Univ Med Sci, Student Res Comm, Tabriz, Iran.
   [Jafarabadi, Mohammad Asghari] Tabriz Univ Med Sci, Rd Traff Injury Res Ctr, Tabriz, Iran.
   [Jafarabadi, Mohammad Asghari] Tabriz Univ Med Sci, Fac Hlth, Dept Epidemiol & Biostat, Tabriz, Iran.
C3 Tabriz University of Medical Science; Tabriz University of Medical
   Science; Tabriz University of Medical Science; Tabriz University of
   Medical Science
RP Khodarahmi, M (corresponding author), Tabriz Univ Med Sci, Fac Nutr & Food Sci, Nutr Res Ctr, Tabriz, Iran.; Khodarahmi, M (corresponding author), Tabriz Univ Med Sci, Student Res Comm, Tabriz, Iran.
EM Mahdieh_Khodarahmi@yahoo.com
RI khodarahmi, mahdieh/AAJ-9853-2020; Foroumandi, Elaheh/AAC-6700-2021;
   Asghari Jafarabadi, Mohammmad/A-7478-2017
OI Asghari Jafarabadi, Mohammmad/0000-0003-3284-9749
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NR 89
TC 8
Z9 8
U1 0
U2 3
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1436-6207
EI 1436-6215
J9 EUR J NUTR
JI Eur. J. Nutr.
PD MAR
PY 2021
VL 60
IS 2
BP 581
EP 601
DI 10.1007/s00394-020-02458-z
EA JAN 2021
PG 21
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA QK8PU
UT WOS:000605136100006
PM 33399974
DA 2025-06-11
ER

PT J
AU Krivanek, TJ
   Gale, SA
   McFeeley, BM
   Nicastri, CM
   Daffner, KR
AF Krivanek, Taylor J.
   Gale, Seth A.
   McFeeley, Brittany M.
   Nicastri, Casey M.
   Daffner, Kirk R.
TI Promoting Successful Cognitive Aging: A Ten-Year Update
SO JOURNAL OF ALZHEIMERS DISEASE
LA English
DT Review
DE Cognitive aging; cognitive decline; cognitive reserve; dementia; healthy
   aging; healthy lifestyle; mild cognitive impairment; preventive
   medicine; risk reduction
ID TRAUMATIC BRAIN-INJURY; OBSTRUCTIVE SLEEP-APNEA; POLYUNSATURATED
   FATTY-ACIDS; QUALITY-OF-LIFE; RANDOMIZED CONTROLLED-TRIAL;
   MEDITERRANEAN-STYLE DIET; INCREASED DEMENTIA RISK; INTENTIONAL
   WEIGHT-LOSS; HEALTH-CARE UTILIZATION; AIR-POLLUTION EXPOSURE
AB A decade has passed since we published a comprehensive review in this journal addressing the topic of promoting successful cognitive aging, making this a good time to take stock of the field. Because there have been limited large-scale, randomized controlled trials, especially following individuals from middle age to late life, some experts have questioned whether recommendations can be legitimately offered about reducing the risk of cognitive decline and dementia. Despite uncertainties, clinicians often need to at least make provisional recommendations to patients based on the highest quality data available. Converging lines of evidence from epidemiological/cohort studies, animal/basic science studies, human proof-of-concept studies, and human intervention studies can provide guidance, highlighting strategies for enhancing cognitive reserve and preventing loss of cognitive capacity. Many of the suggestions made in 2010 have been supported by additional research. Importantly, there is a growing consensus among major health organizations about recommendations to mitigate cognitive decline and promote healthy cognitive aging. Regular physical activity and treatment of cardiovascular risk factors have been supported by all of these organizations. Most organizations have also embraced cognitively stimulating activities, a heart-healthy diet, smoking cessation, and countering metabolic syndrome. Other behaviors like regular social engagement, limiting alcohol use, stress management, getting adequate sleep, avoiding anticholinergic medications, addressing sensory deficits, and protecting the brain against physical and toxic damage also have been endorsed, although less consistently. In this update, we review the evidence for each of these recommendations and offer practical advice about behavior-change techniques to help patients adopt brain-healthy behaviors.
C1 [Krivanek, Taylor J.; Gale, Seth A.; McFeeley, Brittany M.; Nicastri, Casey M.; Daffner, Kirk R.] Harvard Med Sch, Brigham & Womens Hosp, Ctr Brain Mind Med, Dept Neurol, Hale Bldg Transformat Med, Boston, MA 02115 USA.
C3 Harvard University; Harvard University Medical Affiliates; Brigham &
   Women's Hospital; Harvard Medical School
RP Daffner, KR (corresponding author), Brigham & Womens Hosp, 60 Fenwood Rd, Boston, MA 02115 USA.
EM kdaffner@bwh.harvard.edu
RI McFeeley, Brittany/LOS-9552-2024
OI Krivanek, Taylor/0000-0003-2003-6484; Nicastri,
   Casey/0000-0002-1964-2877; McFeeley, Brittany/0000-0002-4823-6747
FU Wimberly Family Clinical Care Research Fund; Gaudet Family Research
   Fund; Alzheimer Innovation Fund, Brigham and Women's Hospital; Muss
   family; Mortimer/Grubman family; Herman F. Woerner Trust; Patti Piper
   Memorial Fund
FX Funding for this work came from the Wimberly Family Clinical Care
   Research Fund, the Gaudet Family Research Fund, and the Alzheimer
   Innovation Fund, Brigham and Women's Hospital. In addition, the
   Laboratory of Healthy Cognitive Aging at Brigham and Women's Hospital
   has been strongly supported by the Muss family, the Mortimer/Grubman
   family, and the Herman F. Woerner Trust. The Patti Piper Memorial Fund
   has also supported this work and related research endeavors. The authors
   would like to acknowledge Hope Schwartz for her work on several prior
   brain health research efforts, including the ongoing Brain Health
   Champion Study.
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U2 47
PU IOS PRESS
PI AMSTERDAM
PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS
SN 1387-2877
EI 1875-8908
J9 J ALZHEIMERS DIS
JI J. Alzheimers Dis.
PY 2021
VL 81
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DI 10.3233/JAD-201462
PG 50
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology
GA SN6KB
UT WOS:000658395500002
PM 33935078
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Rodriguez-Lopez, S
   Palkowski, S
   Gerdung, C
   Keto-Lambert, D
   Sebastianski, M
   Castro-Codesal, ML
AF Rodriguez-Lopez, Sara
   Palkowski, Stefan
   Gerdung, Christopher
   Keto-Lambert, Diana
   Sebastianski, Meghan
   Castro-Codesal, Maria Luisa
TI Does obstructive sleep apnoea contribute to obesity, hypertension and
   kidney dysfunction in children? A systematic review protocol
SO BMJ OPEN
LA English
DT Review
DE paediatric thoracic medicine; paediatric nephrology; sleep medicine
ID POSITIVE AIRWAY PRESSURE; INSULIN-RESISTANCE; BLOOD-PRESSURE;
   RISK-FACTORS; METABOLIC SYNDROME; OXIDATIVE STRESS; ADOLESCENTS;
   ADENOTONSILLECTOMY; INFLAMMATION; PARAMETERS
AB Introduction Childhood obstructive sleep apnoea (OSA) is a highly prevalent disorder that may directly contribute to the development of obesity, hypertension and renal injury. Although those associations seem to be clearer in adults, studies in children have revealed conflicting results and updated synthesis of the evidence is lacking. The aim of this systematic review is to summarise the available evidence on the effect of OSA on obesity, systemic blood pressure and kidney function, to help to elucidate whether respiratory interventions to correct OSA would have the potential to improve those outcomes.
   Methods and analysis A systematic literature review search was created by a medical librarian and peer-reviewed by a second librarian prior to running. Ovid Medline, Ovid Embase, CINAHL via EbscoHOST, Wiley Cochrane Library and ProQuest Dissertations and Theses Global were searched on 25 February 2020. Titles and abstracts will be screened by two independent reviewers for inclusion, followed by full-text screening of relevant articles. Studies in children will be included if they report data on OSA and weight, systemic blood pressure or kidney parameters. The extracted data will be combined for analysis and the information subcategorised in groups based on outcome. Risk of bias will be determined using tools specific to study methodology and certainty of the evidence using the Grading of Recommendations, Assessment, Development and Evaluations approach.
   Ethics and dissemination This study will provide essential information for healthcare professionals to better understand the relationship between childhood OSA and changes in body mass index, systemic blood pressure and kidney function indicators. Our findings will be disseminated through conferences and publications. The results of this review may guide the initiation of new strategies and the development of future research studies. This research did not involve human subjects and therefore did not undergo research ethical review. PROSPERO registration number CRD42020171186.
C1 [Rodriguez-Lopez, Sara] Stollery Childrens Hosp, Nephrol, Edmonton, AB, Canada.
   [Rodriguez-Lopez, Sara; Palkowski, Stefan; Gerdung, Christopher; Keto-Lambert, Diana; Sebastianski, Meghan; Castro-Codesal, Maria Luisa] Univ Alberta, Fac Med & Dent, Pediat, Edmonton, AB, Canada.
   [Palkowski, Stefan] Stollery Childrens Hosp, Pediat, Edmonton, AB, Canada.
   [Gerdung, Christopher; Castro-Codesal, Maria Luisa] Stollery Childrens Hosp, Resp Med, Edmonton, AB, Canada.
   [Keto-Lambert, Diana; Sebastianski, Meghan] Univ Alberta, Alberta Strategy Patient Oriented Res SPOR Knowle, Edmonton, AB, Canada.
C3 Stollery Children's Hospital; University of Alberta; Stollery Children's
   Hospital; Stollery Children's Hospital; University of Alberta
RP Castro-Codesal, ML (corresponding author), Univ Alberta, Fac Med & Dent, Pediat, Edmonton, AB, Canada.; Castro-Codesal, ML (corresponding author), Stollery Childrens Hosp, Resp Med, Edmonton, AB, Canada.
EM castroco@ualberta.ca
RI Castro-Codesal, Maria/D-2327-2015
OI Castro-Codesal, Maria/0000-0002-1079-2502; Rodriguez-Lopez,
   Sara/0000-0003-0543-4855; Sebastianski, Meghan/0000-0002-5206-8731;
   Keto-Lambert, Diana/0000-0002-2317-7269
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NR 70
TC 5
Z9 6
U1 0
U2 2
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2044-6055
J9 BMJ OPEN
JI BMJ Open
PY 2020
VL 10
IS 8
AR e039342
DI 10.1136/bmjopen-2020-039342
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA NQ7MH
UT WOS:000571053200001
PM 32868367
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Wilmanns, JC
   Pandey, R
   Hon, O
   Chandran, A
   Schilling, JM
   Forte, E
   Wu, Q
   Cagnone, G
   Bais, P
   Philip, V
   Coleman, D
   Kocalis, H
   Archer, SK
   Pearson, JT
   Ramialison, M
   Heineke, J
   Patel, HH
   Rosenthal, NA
   Furtado, MB
   Costa, MW
AF Wilmanns, Julia C.
   Pandey, Raghav
   Hon, Olivia
   Chandran, Anjana
   Schilling, Jan M.
   Forte, Elvira
   Wu, Qizhu
   Cagnone, Gael
   Bais, Preeti
   Philip, Vivek
   Coleman, David
   Kocalis, Heidi
   Archer, Stuart K.
   Pearson, James T.
   Ramialison, Mirana
   Heineke, Joerg
   Patel, Hemal H.
   Rosenthal, Nadia A.
   Furtado, Milena B.
   Costa, Mauro W.
TI Metformin intervention prevents cardiac dysfunction in a murine model of
   adult congenital heart disease
SO MOLECULAR METABOLISM
LA English
DT Article
DE Adult congenital heart disease; Metabolism; Obesity; Metformin
ID MYOCARDIAL-INFARCTION; ENERGY-METABOLISM; UNITED-STATES; MOUSE MODEL;
   NKX2-5; FAILURE; MUTATION; CARDIOMYOPATHY; HYPERTROPHY; FLEXIBILITY
AB Objective: Congenital heart disease (CHD) is the most frequent birth defect worldwide. The number of adult patients with CHD, now referred to as ACHD, is increasing with improved surgical and treatment interventions. However the mechanisms whereby ACHD predisposes patients to heart dysfunction are still unclear. ACHD is strongly associated with metabolic syndrome, but how ACHD interacts with poor modern lifestyle choices and other comorbidities, such as hypertension, obesity, and diabetes, is mostly unknown.
   Methods: We used a newly characterized mouse genetic model of ACHD to investigate the consequences and the mechanisms associated with combined obesity and ACHD predisposition. Metformin intervention was used to further evaluate potential therapeutic amelioration of cardiac dysfunction in this model.
   Results: ACHD mice placed under metabolic stress (high fat diet) displayed decreased left ventricular ejection fraction. Comprehensive physiological, biochemical, and molecular analysis showed that ACHD hearts exhibited early changes in energy metabolism with increased glucose dependence as main cardiac energy source. These changes preceded cardiac dysfunction mediated by exposure to high fat diet and were associated with increased disease severity. Restoration of metabolic balance by metformin administration prevented the development of heart dysfunction in ACHD predisposed mice.
   Conclusions: This study reveals that early metabolic impairment reinforces heart dysfunction in ACHD predisposed individuals and diet or pharmacological interventions can be used to modulate heart function and attenuate heart failure. Our study suggests that interactions between genetic and metabolic disturbances ultimately lead to the clinical presentation of heart failure in patients with ACHD. Early manipulation of energy metabolism may be an important avenue for intervention in ACHD patients to prevent or delay onset of heart failure and secondary comorbidities. These interactions raise the prospect for a translational reassessment of ACHD presentation in the clinic. (C) 2018 The Authors. Published by Elsevier GmbH.
C1 [Pandey, Raghav; Hon, Olivia; Forte, Elvira; Bais, Preeti; Philip, Vivek; Coleman, David; Kocalis, Heidi; Rosenthal, Nadia A.; Furtado, Milena B.; Costa, Mauro W.] Jackson Lab, 600 Main St, Bar Harbor, ME 04609 USA.
   [Wilmanns, Julia C.; Chandran, Anjana; Ramialison, Mirana; Rosenthal, Nadia A.; Furtado, Milena B.; Costa, Mauro W.] Monash Univ, Australian Regenerat Med Inst, Clayton, Vic, Australia.
   [Heineke, Joerg] Hannover Med Sch, Expt Cardiol, Dept Cardiol & Angiol, Hannover, Germany.
   [Schilling, Jan M.; Patel, Hemal H.] VA San Diego Healthcare Syst, San Diego, CA USA.
   [Schilling, Jan M.; Patel, Hemal H.] Univ Calif San Diego, Dept Anesthesiol, La Jolla, CA 92093 USA.
   [Wu, Qizhu; Pearson, James T.] Monash Univ, Monash Biomed Imaging, Clayton, Vic, Australia.
   [Cagnone, Gael] CHU St Justine, Res Ctr, Dept Pharmacol, Montreal, PQ, Canada.
   [Archer, Stuart K.] Monash Univ, Monash Bioinformat Platform, Clayton, Vic, Australia.
   [Archer, Stuart K.] Monash Univ, Fac Med Nursing & Hlth Sci, Biomed Discovery Inst, Clayton, Vic, Australia.
   [Pearson, James T.] Monash Univ, Dept Physiol, Clayton, Vic, Australia.
   [Pearson, James T.] Natl Cerebral & Cardiovasc Ctr, Suita, Osaka 5658565, Japan.
   [Ramialison, Mirana] Syst Biol Inst, Clayton, Vic, Australia.
   [Rosenthal, Nadia A.] Imperial Coll London, Natl Heart & Lung Inst, London W12 0NN, England.
C3 Jackson Laboratory; Australian Regenerative Medicine Institute; Monash
   University; Hannover Medical School; US Department of Veterans Affairs;
   Veterans Health Administration (VHA); VA San Diego Healthcare System;
   University of California System; University of California San Diego;
   Monash University; Universite de Montreal; Centre Hospitalier
   Universitaire Sainte-Justine; Monash University; Monash University;
   Monash University; National Cerebral & Cardiovascular Center - Japan;
   Imperial College London
RP Costa, MW (corresponding author), Jackson Lab, 600 Main St, Bar Harbor, ME 04609 USA.
EM mauro.costa@jax.org
RI Ramialison, Mirana/AEG-6305-2022; Rosenthal, Nadia/H-4012-2013; Forte,
   Elvira/AAO-4000-2020; Heineke, Joerg/LXB-0676-2024; Costa,
   Mauro/S-9219-2018; Pearson, James/B-4631-2012
OI Bais, Preeti/0009-0004-1582-8430; Philip, Vivek/0000-0001-5126-707X;
   Forte, Elvira/0000-0002-5555-9122; Rosenthal, Nadia/0000-0002-7599-7365;
   Cagnone, Gael/0000-0001-9664-3518; Costa, Mauro/0000-0003-3579-8625;
   Archer, Stuart/0000-0003-0450-1243; Ramialison,
   Mirana/0000-0001-6315-4777; Pearson, James/0000-0002-3318-5406
FU State Government of Victoria; Australian Government;
   Konrad-Adenauer-Stiftung e.V.; National Cerebral & Cardiovascular Center
   [27-2-2]; NHMRC Project [1069710]; NHMRC-Australia Fellowship; ARC Stem
   Cells Australia; Saving Tiny Hearts Society grant; NHMRC/NHF [1049980
   CDF]; National Health and Medical Research Council of Australia
   [1069710] Funding Source: NHMRC
FX The Australian Regenerative Medicine Institute is supported by grants
   from the State Government of Victoria and the Australian Government. JCW
   was supported by Konrad-Adenauer-Stiftung e.V. JTP was supported by an
   intramural grant of National Cerebral & Cardiovascular Center (27-2-2).
   This work was funded by NHMRC Project grant 1069710 to MWC, MR and NAR;
   NHMRC-Australia Fellowship to NAR, NHMRC/NHF 1049980 CDF to MR, and ARC
   Stem Cells Australia to NAR and Saving Tiny Hearts Society grant to MWC.
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NR 70
TC 13
Z9 15
U1 1
U2 13
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2212-8778
J9 MOL METAB
JI Mol. Metab.
PD FEB
PY 2019
VL 20
BP 102
EP 114
DI 10.1016/j.molmet.2018.11.002
PG 13
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA HJ0AM
UT WOS:000456819100009
PM 30482476
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Gamede, M
   Mabuza, L
   Ngubane, P
   Khathi, A
AF Gamede, Mlindeli
   Mabuza, Lindokuhle
   Ngubane, Phikelelani
   Khathi, Andile
TI Plant-Derived Oleanolic Acid (OA) Ameliorates Risk Factors of
   Cardiovascular Diseases in a Diet-Induced Pre-Diabetic Rat Model:
   Effects on Selected Cardiovascular Risk Factors
SO MOLECULES
LA English
DT Article
DE pre-diabetes; dyslipidemia; cardiovascular disease; arterial pressure
   and inflammation
ID TRIGLYCERIDE-RICH LIPOPROTEINS; INSULIN-RESISTANCE; ADIPOSE-TISSUE;
   METABOLIC SYNDROME; DIABETES-MELLITUS; FAT ACCUMULATION; ECTOPIC FAT;
   PATHOGENESIS; OBESITY; EPIDEMIOLOGY
AB The pathogenesis of prediabetes is associated with risk factors such as chronic consumption of an unhealthy diet. Recent studies have reported that diet-induced pre-diabetes is also associated with risk factors of cardiovascular complications, hence this study was aimed at evaluating the effects of oleanolic acid (OA) on pre-diabetes rats. Pre-diabetes was induced by chronic exposure of Sprague Dawley rats (SD) to high-fat high-carbohydrate diet (20 weeks), whereas the non-pre-diabetes control (NC) was given standard rat chow. Pre-diabetes animals were grouped into five groups namely prediabetes control (PC), metformin treated (Met), metformin with diet intervention (Met + DI), oleanolic acid treated (OA), and oleanolic acid with diet intervention (OA + DI) then treated for 12 weeks. At the end of treatment, all animals were sacrificed where organs and tissues were harvested for biochemical analysis and histological studies. The results showed that PC had a significantly higher triglycerides (TGs), low density lipoprotein cholesterol (LDL-C, interleukin-6(IL-6), tumor necrosis factor alpha (TNF), C-reactive protein (CRP), mean arterial pressure (MAP) and hearts weights in comparison to NC (p < 0.05). However, the administration of OA, in both the presence and absence of dietary intervention showed a significant decrease in TGs, LDL-C, IL-6, TNF, CRP, MAP, hearts weights (p < 0.05). In conclusion, the administration of OA was able to lower the risks of developing CVDs in pre-diabetes rat model through ameliorating dyslipidaemia, oxidative stress, hypertension, and low-grade inflammation. Therefore OA has the potential to be used as an alternative treatment to prevent the onset of CVDs during pre-diabetes stage even in the absence of dietary and lifestyle intervention.
C1 [Gamede, Mlindeli; Mabuza, Lindokuhle; Ngubane, Phikelelani; Khathi, Andile] Univ KwaZulu Natal, Dept Human Physiol, Sch Lab Med & Med Sci, Coll Hlth Sci, X54001, Durban, South Africa.
C3 University of Kwazulu Natal
RP Khathi, A (corresponding author), Univ KwaZulu Natal, Dept Human Physiol, Sch Lab Med & Med Sci, Coll Hlth Sci, X54001, Durban, South Africa.
EM 213571877@stu.ukzn.ac.za; 211509843@stu.ukzn.ac.za;
   Ngubanep1@ukzn.ac.za; khathia@ukzn.ac.za
RI Khathi, Andile/S-9664-2019
OI Gamede, Mlindeli/0000-0001-5512-1545; Mabuza, Lindokuhle
   Patience/0000-0003-2272-8505
FU National Research Foundation (South Africa) [106041]
FX This research was funded by the National Research Foundation (South
   Africa) grant number [106041].
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NR 56
TC 32
Z9 35
U1 0
U2 10
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1420-3049
J9 MOLECULES
JI Molecules
PD JAN 2
PY 2019
VL 24
IS 2
AR 340
DI 10.3390/molecules24020340
PG 13
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA HJ4IH
UT WOS:000457137200126
PM 30669379
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Azuma, M
   Le, TD
   Yoshimoto, Y
   Hiraki, N
   Yamanaka, M
   Omura, F
   Inoue, YH
AF Azuma, M.
   Le, T. Dat
   Yoshimoto, Y.
   Hiraki, N.
   Yamanaka, M.
   Omura, F.
   Inoue, Y. H.
TI RNA-seq analysis of diet-driven obesity and anti-obesity effects of
   quercetin glucoside or epigallocatechin gallate in Drosophila
   adults
SO EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
LA English
DT Article
DE RNA sequence; Drosophila; High-fat diet; Fat accumulation; Catechin;
   Quercetin
ID HIGH-FAT-DIET; GREEN TEA POLYPHENOL; METABOLIC SYNDROME; ADIPOSE-TISSUE;
   POTENTIAL ROLE; (-)-EPIGALLOCATECHIN-3-GALLATE; INFLAMMATION;
   MECHANISMS; CATECHINS; MODEL
AB OBJECTIVE: High-fat diet (HFD) feeding stimulates fat accumulation in mammals and Drosophila. In the present study, we examined whether simultaneous feeding of familiar anti-obesity drugs, quercetin glycosides (QG) and epigallocatechin gallate (EGCG), to Drosophila has the same suppressive effect on fat accumulation as previously reported in rats and mice. To understand the underlying molecular mechanisms of HFD diet-induced obesity and the suppression effect of the drugs, we performed transcriptome analyses.
   MATERIALS AND METHODS: We induced extra fat accumulation by feeding Drosophila fly food containing 20% coconut oil and quantified the triglyceride accumulated in flies. The effects of anti-obesity drugs were also evaluated. We isolated total RNA from each sample and performed RNA-seq analyses and quantitive Real Time-Polymerase Chain Reaction (qRT-PCR) to investigate altered gene expression.
   RESULTS: The mRNA levels of several genes involved in lipid metabolism. glycolysis/gluconeogenesis. and anti-oxidative stress changed in HFD-fed adults. Moreover, the levels altered in those fed an HFD with QG or EGCG. The qRT-PCR further confirmed the RNA-seq data. suggesting that the expression of five essential genes for lipid metabolism changed in HFD-fed flies and altered in the flies treated with anti-obesity drugs. The most remarkable alteration was observed in the dHSL gene encoding a lipase involved in lipid-storage after HFD feeding and HFD with QG or EGCG. These alterations are consistent with HFD-induced fat accumulation as well as the anti-obesity effects of the drugs in mammals. suggesting that the genes play an important role in anti-obesity effects.
   CONCLUSIONS: These are the first reports to date of entire profiles of altered gene expression under the conditions of diet-induced obesity and its suppression by anti-obesity drugs in Drosophila.
C1 [Azuma, M.; Le, T. Dat; Inoue, Y. H.] Kyoto Inst Technol, Insect Biomed Res Ctr, Sakyo Ku, Kyoto, Japan.
   [Yoshimoto, Y.; Hiraki, N.; Yamanaka, M.; Omura, F.] Suntory Global Innovat Ctr Ltd, Kyoto, Japan.
C3 Kyoto Institute of Technology; Suntory Holdings Ltd
RP Inoue, YH (corresponding author), Kyoto Inst Technol, Insect Biomed Res Ctr, Sakyo Ku, Kyoto, Japan.
EM yhinoue@kit.ac.jp
FU Joint Research Fund from Suntory Global Innovation Ltd; Joint Research
   Program of Advanced Insect Research Promotion Centre in Kyoto Institute
   of Technology [2017008]
FX This study was partly supported by the Joint Research Fund from Suntory
   Global Innovation Ltd and Joint Research Program of Advanced Insect
   Research Promotion Centre in Kyoto Institute of Technology (2017008).
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NR 66
TC 11
Z9 12
U1 2
U2 22
PU VERDUCI PUBLISHER
PI ROME
PA VIA GREGORIO VII, ROME, 186-00165, ITALY
SN 1128-3602
J9 EUR REV MED PHARMACO
JI Eur. Rev. Med. Pharmacol. Sci.
PD JAN
PY 2019
VL 23
IS 2
BP 857
EP 876
PG 20
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA HK1UU
UT WOS:000457693100050
PM 30720195
DA 2025-06-11
ER

PT J
AU Bento, C
   Matos, AC
   Cordeiro, A
   Ramalho, A
AF Bento, Claudia
   Matos, Andrea C.
   Cordeiro, Adryana
   Ramalho, Andrea
TI Vitamin A deficiency is associated with body mass index and body
   adiposity in women with recommended intake of vitamin A
SO NUTRICION HOSPITALARIA
LA English
DT Article
DE Overweight; Obesity; Retinol; beta-carotene; Night blindness; Body
   adiposity
ID RETINOL-BINDING-PROTEIN; INSULIN SENSITIVITY; METABOLIC SYNDROME;
   OXIDATIVE STRESS; SERUM-LEVELS; OBESITY; SUPPLEMENTATION; BIOMARKERS;
   CAROTENE; RISK
AB Introduction: evidence indicates that vitamin A is involved in regulating fat mass. A low consumption of vitamin A has been reported in individuals with obesity, as have lower concentrations of this vitamin, than in eutrophic individuals when their dietary intake of vitamin A is not significantly different.
   Objective: to investigate vitamin A nutritional status and its association with body mass index (BMI) and body fat in women who have the recommended dietary intake of vitamin A.
   Methods: cross-sectional study with 200 women, paired by age and by the dietary intake of vitamin A recommended. Participants were divided into four groups, according to BMI. Anthropometric data were evaluated (weight, BMI and waist circumference [WC]), as well as the diagnosis of night blindness (NB). Lipid and glycemic profiles were measured. The cut-off points for deficiency of serum concentrations of retinol and beta-carotene were < 1.05 mu mol/l and 40 mu g/dl, respectively. The recommended dietary intake of vitamin A was 700 mu g/day.
   Results: there was a significant drop in retinol concentrations according to BMI (p < 0.001) and WC (p < 0.001). We found beta-carotene to behave similarly (p = 0.005; p < 0.001). We found NB in 7.5% of overweight (OW) cases and 20.0% of obesity class II (OII), and no functional alteration was found in the eutrophic group (EU). Inadequate levels of retinol and beta-carotene increased the odds ratio for the occurrence of OW, obesity class I (OI) and OII, as well as inadequate WC.
   Conclusion: even with recommended intake of vitamin A, we found a biochemical and functional inadequacy of vitamin A nutritional status, associated with overweight, obesity and body adiposity.
C1 [Bento, Claudia] Univ Fed Rio de Janeiro, Human Nutr, Rio de Janeiro, Brazil.
   [Matos, Andrea C.] Univ Fed Rio de Janeiro, Med Clin, Rio de Janeiro, Brazil.
   [Matos, Andrea C.] Univ Fed Fluminense, Dept Nutr & Dietet, Rio De Janeiro, Brazil.
   [Matos, Andrea C.; Ramalho, Andrea] INJC, Micronutrients Res Ctr NPqM, Rio De Janeiro, Brazil.
   [Cordeiro, Adryana] Univ Fed Rio de Janeiro, Fac Med, Rio de Janeiro, Brazil.
   [Cordeiro, Adryana] Univ Fed Rio de Janeiro, Micronutrients Res Ctr NPqM, Rio De Janeiro, Brazil.
   [Ramalho, Andrea] Fundacao Oswaldo Cruz FIOCRUZ, Publ Hlth, Rio De Janeiro, Brazil.
   [Ramalho, Andrea] Univ Fed Rio de Janeiro, Social Appl Nutr Dept, Rio de Janeiro, Brazil.
C3 Universidade Federal do Rio de Janeiro; Universidade Federal do Rio de
   Janeiro; Universidade Federal Fluminense; Universidade Federal do Rio de
   Janeiro; Universidade Federal do Rio de Janeiro; Fundacao Oswaldo Cruz;
   Universidade Federal do Rio de Janeiro
RP Cordeiro, A (corresponding author), Univ Fed Rio de Janeiro, Dept Social Appl Nutr, Micronutrients Res Ctr NPqM, Ilha Fundao, Ave Brigadeiro Trompovwsky S-N Subsolo,Bloco J, BR-21941590 Rio De Janeiro, Brazil.
EM adrynutri@yahoo.com.br
RI Matos, Andrea/X-6321-2019
FU National Council of Technological
FX We thank the National Council of Technological for their research
   support to this study.
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NR 39
TC 22
Z9 23
U1 0
U2 2
PU ARAN EDICIONES, S L
PI MADRID
PA C/ CASTELLO, 128, 1O, MADRID, 28006, SPAIN
SN 0212-1611
EI 1699-5198
J9 NUTR HOSP
JI Nutr. Hosp.
PD SEP-OCT
PY 2018
VL 35
IS 5
BP 1072
EP 1078
DI 10.20960/nh.1630
PG 7
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA HG6II
UT WOS:000455084200012
PM 30307289
OA gold
DA 2025-06-11
ER

PT J
AU Matsukuma, Y
   Masutani, K
   Tanaka, S
   Tsuchimoto, A
   Fujisaki, K
   Torisu, K
   Katafuchi, R
   Hirakata, H
   Tsuruya, K
   Kitazono, T
AF Matsukuma, Yuta
   Masutani, Kosuke
   Tanaka, Shigeru
   Tsuchimoto, Akihiro
   Fujisaki, Kiichiro
   Torisu, Kumiko
   Katafuchi, Ritsuko
   Hirakata, Hideki
   Tsuruya, Kazuhiko
   Kitazono, Takanari
TI A J-shaped association between serum uric acid levels and poor renal
   survival in female patients with IgA nephropathy
SO HYPERTENSION RESEARCH
LA English
DT Article
DE end-stage renal disease (ESRD); hypouricemia; Oxford classification;
   oxidative stress; risk prediction
ID GLOMERULAR-FILTRATION-RATE; ACUTE KIDNEY INJURY; OXFORD CLASSIFICATION;
   CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; URATE TRANSPORTER; PLASMA
   CREATININE; FOLLOW-UP; ALL-CAUSE; RISK
AB Recently, low serum uric acid (SUA) levels and high SUA levels, have emerged as risk factors for cardiovascular disease, as well as for the incidence of acute kidney injury and chronic kidney disease (CKD). However, the effect of low SUA on the progression of CKD remains unclear. To evaluate the association between SUA and renal prognosis in patients with immunoglobulin A nephropathy (IgAN), one of the most common causes of CKD, we retrospectively followed 1218 patients who were diagnosed with primary IgAN by kidney biopsy between October 1979 and December 2010. Patients were divided into three groups on the basis of SUA level tertiles: low (L group), middle (M group) and high (H group)tertiles(<6.1, 6.1-7.0, and >7.0 mg dl(-1), respectively, for men and <4.4, 4.4-5.3, and 45.3 mg dl(-1), respectively, for women). The risk factors for developing end-stage renal disease (ESRD) were estimated using a Cox proportional hazards model. After a median follow-up of 5.1 years, 142 patients (11.7%) developed ESRD. The hazard ratio (95% confidence interval) showed a J-shaped trend with the tertiles in both men (1.18 (0.55-2.54), 1.00 (reference), and 1.80 (1.01-3.10) in L, M and H groups, respectively) and women (2.73 (1.10-6.76), 1.00 (reference) and 2.49 (1.16-5.34) in L, M and H groups, respectively). Notably, low SUA was significantly associated with incident ESRD in women. This finding suggests that SUA has a J-shaped association with ESRD in patients with IgAN, especially women.
C1 [Matsukuma, Yuta; Masutani, Kosuke; Tanaka, Shigeru; Tsuchimoto, Akihiro; Fujisaki, Kiichiro; Torisu, Kumiko; Tsuruya, Kazuhiko; Kitazono, Takanari] Kyushu Univ, Grad Sch Med Sci, Dept Med & Clin Sci, Fukuoka, Japan.
   [Katafuchi, Ritsuko] Natl Fukuoka Higashi Med Ctr, Kidney Unit, Koga, Japan.
   [Hirakata, Hideki] Japanese Red Cross Fukuoka Hosp, Nephrol & Dialysis Ctr, Fukuoka, Japan.
   [Tsuruya, Kazuhiko] Kyushu Univ, Grad Sch Med Sci, Dept Integrated Therapy Chron Kidney Dis, Fukuoka, Japan.
C3 Kyushu University; Kyushu University
RP Tsuruya, K (corresponding author), Kyushu Univ, Grad Sch Med Sci, Dept Integrated Therapy Chron Kidney Dis, Higashi Ku, 3-1-1 Maidashi, Fukuoka 8128582, Japan.
EM tsuruya@intmed2.med.kyushu-u.ac.jp
RI Tanaka, Shigeru/HZI-6869-2023; Torisu, Kumiko/ABE-7626-2021
FU Grants-in-Aid for Scientific Research [16K11066] Funding Source: KAKEN
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NR 38
TC 21
Z9 24
U1 0
U2 9
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0916-9636
EI 1348-4214
J9 HYPERTENS RES
JI Hypertens. Res.
PD MAR
PY 2017
VL 40
IS 3
BP 291
EP 297
DI 10.1038/hr.2016.134
PG 7
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA EN1ZW
UT WOS:000395810100012
PM 27733763
DA 2025-06-11
ER

PT J
AU Scoditti, E
   Massaro, M
   Carluccio, MA
   Pellegrino, M
   Wabitsch, M
   Calabriso, N
   Storelli, C
   De Caterina, R
AF Scoditti, Egeria
   Massaro, Marika
   Carluccio, Maria Annunziata
   Pellegrino, Mariangela
   Wabitsch, Martin
   Calabriso, Nadia
   Storelli, Carlo
   De Caterina, Raffaele
TI Additive Regulation of Adiponectin Expression by the Mediterranean Diet
   Olive Oil Components Oleic Acid and Hydroxytyrosol in Human Adipocytes
SO PLOS ONE
LA English
DT Article
ID NECROSIS-FACTOR-ALPHA; N-TERMINAL KINASE; FREE FATTY-ACIDS;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; ADIPOSE-TISSUE; OBESITY; LEPTIN;
   DIFFERENTIATION; CELLS
AB Adiponectin, an adipocyte-derived insulin-sensitizing and anti-inflammatory hormone, is suppressed in obesity through mechanisms involving chronic inflammation and oxidative stress. Olive oil consumption is associated with beneficial cardiometabolic actions, with possible contributions from the antioxidant phenol hydroxytyrosol (HT) and the monounsaturated fatty acid oleic acid (OA, 18:1n-9 cis), both possessing anti-inflammatory and vasculo-protective properties. We determined the effects of HT and OA, alone and in combination, on adiponectin expression in human and murine adipocytes under pro-inflammatory conditions induced by the cytokine tumor necrosis factor(TNF)-alpha. We used human Simpson-Golabi-Behmel syndrome (SGBS) adipocytes and murine 3T3-L1 adipocytes as cell model systems, and pretreated them with 1-100 mu mol/L OA, 0.1-20 mu mol/L HT or OA plus HT combination before stimulation with 10 ng/mL TNF-alpha. OA or HT significantly (P<0.05) prevented TNF-alpha-induced suppression of total adiponectin secretion (by 42% compared with TNF-alpha alone) as well as mRNA levels (by 30% compared with TNF-alpha alone). HT and OA also prevented-by 35%-TNF-alpha-induced downregulation of peroxisome proliferator-activated receptor PPAR gamma. Co-treatment with HT and OA restored adiponectin and PPAR gamma expression in an additive manner compared with single treatments. Exploring the activation of JNK, which is crucial for both adiponectin and PPAR gamma suppression by TNF-alpha, we found that HT and OA additively attenuated TNF-alpha-stimulated JNK phosphorylation (up to 55% inhibition). In conclusion, the virgin olive oil components OA and HT, at nutritionally relevant concentrations, have additive effects in preventing adiponectin downregulation in inflamed adipocytes through an attenuation of JNK-mediated PPAR gamma suppression.
C1 [Scoditti, Egeria; Massaro, Marika; Carluccio, Maria Annunziata; Calabriso, Nadia] Natl Res Council CNR, Inst Clin Physiol, Lecce, Italy.
   [Pellegrino, Mariangela; Storelli, Carlo] Univ Salento, Dept Biol & Environm Sci & Technol DISTEBA, Lecce, Italy.
   [Wabitsch, Martin] Univ Ulm, Dept Pediat & Adolescent Med, Div Pediat Endocrinol Diabet & Obes, D-89069 Ulm, Germany.
   [De Caterina, Raffaele] Univ G DAnnunzio, Chieti, Italy.
   [De Caterina, Raffaele] Ctr Excellence Aging, Chieti, Italy.
   [De Caterina, Raffaele] G Monasterio Fdn Clin Res, Pisa, Italy.
C3 Consiglio Nazionale delle Ricerche (CNR); Istituto di Fisiologia Clinica
   (IFC-CNR); University of Salento; Ulm University; G d'Annunzio
   University of Chieti-Pescara
RP De Caterina, R (corresponding author), Univ G DAnnunzio, Chieti, Italy.
EM rdecater@unich.it
RI De Caterina, Raffaele/K-3857-2016; massaro, marika/AAQ-1204-2020;
   Carluccio, Maria/AAO-1683-2020; SCODITTI, EGERIA/J-8609-2016
OI Massaro, Marika/0000-0001-6124-5077; Calabriso,
   Nadia/0000-0003-0726-2081; CARLUCCIO, MARIA
   ANNUNZIATA/0000-0002-8307-1829; SCODITTI, EGERIA/0000-0003-2753-8487
FU CNR Institute of Clinical Physiology, Pisa, Italy; Apulian Region POR
   Strategic Projects [CIP PS_101, CIP PS_008]; National Operational
   Program for Research and Competitiveness [PON01_01958]
FX This work was supported by grants from the CNR Institute of Clinical
   Physiology, Pisa, Italy (Junior Grant 2009 to E. Scoditti), the Apulian
   Region POR Strategic Projects (CIP PS_101, CIP PS_008), and the National
   Operational Program for Research and Competitiveness 2007-2013
   (PON01_01958, PIVOLIO project). The funders had no role in study design,
   data collection and analysis, decision to publish, or preparation of the
   manuscript.
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NR 58
TC 59
Z9 62
U1 0
U2 17
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JUN 1
PY 2015
VL 10
IS 6
AR e0128218
DI 10.1371/journal.pone.0128218
PG 23
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA CL0KF
UT WOS:000356630900129
PM 26030149
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Kuznetsova, LA
   Plesneva, SA
   Sharova, TS
   Pertseva, MN
   Shpakov, AO
AF Kuznetsova, L. A.
   Plesneva, S. A.
   Sharova, T. S.
   Pertseva, M. N.
   Shpakov, A. O.
TI Attenuation of inhibitory influence of hormones on adenylyl cyclase
   systems in the myocardium and brain of obese and type 2 diabetic rats as
   affected by the intranasal insulin treatment
SO JOURNAL OF EVOLUTIONARY BIOCHEMISTRY AND PHYSIOLOGY
LA English
DT Review
DE adenylyl cyclase; somatostatine; 5-nonyloxytryptamine; obesity; type 2
   diabetes mellitus; insulin
ID G-PROTEIN EXPRESSION; OXIDATIVE STRESS; RECEPTOR; MODEL; SENSITIVITY;
   GENERATION; SEROTONIN; 5-HT1B
AB The functional state of adenylyl cyclase signaling system (ACSS) and its regulation by the hormones and the inhibitor of adenylyl cyclase (AC), somatostatine (SST), in the brain and myocardium and by 5-nonyloxytryptamine (5-NOT) in the brain of rats of different ages (2- and 7-month-old) with experimental obesity and combination of obesity and type 2 diabetes mellitus (DM2), as well as the effect of the long-term treatment with intranasally administered insulin (II) on ACSS were studied. It was shown that the basal AC activity in obese and DM2 rats increases in the myocardium and, to a lesser extent, in the brain and decreases under the II treatment. The AC stimulating effect of forskolin decreases in the myocardium, but not in the brain of obese and DM2 rats. The II treatment recovers the AC stimulating effect of forskolin in 7-month-old animals, but has little effect in 5-month-old rats. In obesity as well as under the II treatment, the basal AC activity and its stimulation by forskolin change insignificantly. The AC inhibitory effects of 5-NOT and, particularly, SST are strongly attenuated in the investigated pathology, supposedly due to a reduction in the functional activity of G(i)-proteins. The treatment of obesity and its combination with DM2 recovers, completely or partially, the AC inhibitory effects of hormones, most of all in the brain. Since the ACSS dysfunctions are causal to metabolic syndrome and DM2, their elimination by the II treatment promises an effective approach to combat these pathologies and their CNS and cardiovascular complications.
C1 [Kuznetsova, L. A.; Plesneva, S. A.; Sharova, T. S.; Pertseva, M. N.; Shpakov, A. O.] Russian Acad Sci, Sechenov Inst Evolutionary Physiol & Biochem, St Petersburg 196140, Russia.
C3 Russian Academy of Sciences; Sechenov Institute of Evolutionary
   Physiology & Biochemistry
RP Kuznetsova, LA (corresponding author), Russian Acad Sci, Sechenov Inst Evolutionary Physiol & Biochem, St Petersburg 196140, Russia.
EM alex_shpakov@list.ru
RI Sharova, Tatyana/AAD-6500-2022; Kuznetsova, Ludmila A./AAD-6596-2022;
   Shpakov, Alexander/R-6581-2016
OI Kuznecova, Ludmila/0000-0001-9215-6018; Shpakov,
   Alexander/0000-0002-4293-3162
FU Russian Foundation for Basic research [14-15-00413]
FX This work was supported by the Russian Foundation for Basic research
   (grant no. 14-15-00413).
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NR 38
TC 1
Z9 1
U1 0
U2 4
PU PLEIADES PUBLISHING INC
PI MOSCOW
PA PLEIADES PUBLISHING INC, MOSCOW, 00000, RUSSIA
SN 0022-0930
EI 1608-3202
J9 J EVOL BIOCHEM PHYS+
JI J. Evol. Biochem. Physiol.
PD SEP
PY 2014
VL 50
IS 5
BP 399
EP 408
DI 10.1134/S0022093014050044
PG 10
WC Biochemistry & Molecular Biology; Evolutionary Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Evolutionary Biology; Physiology
GA AW0FN
UT WOS:000345966600004
DA 2025-06-11
ER

PT J
AU Huang, JH
   Tsai, LC
   Chang, YC
   Cheng, FC
AF Huang, Jui-Hua
   Tsai, Leih-Ching
   Chang, Yu-Chen
   Cheng, Fu-Chou
TI High or low calcium intake increases cardiovascular disease risks in
   older patients with type 2 diabetes
SO CARDIOVASCULAR DIABETOLOGY
LA English
DT Article
DE Calcium; Magnesium; Inflammation; Cardiovascular disease risk; Older
   patients with diabetes
ID C-REACTIVE PROTEIN; ENDOTHELIAL DYSFUNCTION; INFLAMMATORY STRESS;
   METABOLIC SYNDROME; DIETARY MAGNESIUM; GLYCEMIC CONTROL; VITAMIN-D;
   PEOPLE; HEART; COMPLICATIONS
AB Background: We investigated the effects of dietary calcium (Ca) and magnesium (Mg) intakes on cardiovascular disease risks in older patients with diabetes.
   Methods: In this cross-sectional study, 197 patients with type 2 diabetes aged 65 years and above were recruited. The 24-h dietary recalls and 1-week self-reported typical dietary intake patterns were collected. The Ca and Mg intakes of <67% of the recommended dietary allowance (RDA), 67%-100% of RDA, and >100% of RDA were defined as low, moderate, and high Ca and Mg intakes, respectively. Anthropometric measurements were determined and biochemical analysis of blood and urine was performed.
   Results: Our data indicated that 60.9% and 87.3% of our patients were Ca and Mg intakes below RDA, respectively. Patients whose Ca intake was high or low (81.2%) had significantly higher C-reactive protein (CRP) than those whose Ca intake was moderate (p = 0.043). Furthermore, patients whose Mg intake was low (87.3%) had significantly higher CRP than that of those who took adequate Mg (p = 0.025). The dietary Ca: Mg intake ratios were highly correlated with CRP, platelet counts, and red blood cell distribution (p < 0.05). A dietary Ca: Mg intake ratio of 2.0-2.5 was significantly correlated to lower CRP levels (p = 0.013).
   Conclusions: High or low calcium intake increases cardiovascular disease risks. We suggest that "moderate" intake of 402-600 mg Ca/day (approximately 67%-100% of Taiwan RDA for Ca) and adequate Mg intake (or meeting RDA for Mg) with Ca: Mg intake ratio of 2.0-2.5 are important for reducing cardiovascular disease risks in older patients with diabetes.
C1 [Huang, Jui-Hua; Chang, Yu-Chen] Chia Yi Christian Hosp, Dept Community Hlth, Chiayi, Taiwan.
   [Tsai, Leih-Ching] Changhua Christian Hosp, Dept Internal Med, Div Endocrine & Metab, Erlin Branch, Changhua, Taiwan.
   [Chang, Yu-Chen] Chia Yi Christian Hosp, Dept Geriatr Med, Chiayi, Taiwan.
   [Cheng, Fu-Chou] Taichung Vet Gen Hosp, Stem Cell Ctr, Dept Med Res, Taichung, Taiwan.
C3 Changhua Christian Hospital; Taichung Veterans General Hospital
RP Cheng, FC (corresponding author), Taichung Vet Gen Hosp, Stem Cell Ctr, Dept Med Res, Taichung, Taiwan.
EM vc1035@gmail.com
RI Cheng, Chien-shan/I-4065-2019
FU Changhua Christian Hospital, Taiwan
FX This study was supported by the grant from Changhua Christian Hospital,
   Taiwan. The authors have no conflicts of interest. The authors thank all
   the patients, clinic medical staff, and Dr. Jia-zhen Lu in Changhua
   Christian Hospital for their enthusiastic support.
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NR 51
TC 7
Z9 9
U1 0
U2 7
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1475-2840
J9 CARDIOVASC DIABETOL
JI Cardiovasc. Diabetol.
PD AUG 1
PY 2014
VL 13
AR 120
DI 10.1186/s12933-014-0120-0
PG 10
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism
GA AU1CO
UT WOS:000345359000001
PM 25078288
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Dunietz, GL
   Chervin, RD
   O'Brien, LM
AF Dunietz, Galit Levi
   Chervin, Ronald David
   O'Brien, Louise Margaret
TI Sleep-Disordered Breathing During Pregnancy: Future Implications for
   Cardiovascular Health
SO OBSTETRICAL & GYNECOLOGICAL SURVEY
LA English
DT Article
ID POSITIVE AIRWAY PRESSURE; ISCHEMIC-HEART-DISEASE; LONG-TERM MORTALITY;
   RISK-FACTORS; BLOOD-PRESSURE; HYPERTENSIVE PREGNANCY; GESTATIONAL
   HYPERTENSION; GROWTH RESTRICTION; METABOLIC SYNDROME; APNEA SYNDROME
AB Importance Cardiovascular disease (CVD) is a common condition in postreproductive females. Key risk factors for later-life CVD include gestational hypertension (GHTN) and preeclampsia (PE). Although several risk factors of hypertension in pregnancy are well recognized, a novel risk factor that has emerged recently is sleep-disordered breathing (SDB), a condition characterized by repeated closure of the upper airway during sleep with disrupted ventilation and sleep fragmentation. In the nonpregnant population, SDB is now known to play a causal role in future CVD.
   Objective The aim of this study was to propose the hypothesis that occult SDB during pregnancy may play a role in long-term CVD in women who had hypertensive disorders of pregnancy.
   Evidence Acquisition This study is a review and synthesis of empirical evidence that links SDB to GHTN/PE and GHTN/PE to future CVD.
   Results An increasing body of evidence supports the relationship between SDB and hypertensive disorders of pregnancy via mechanisms of inflammation, oxidative stress, and endothelial dysfunction. It is well established that hypertensive disorders of pregnancy are associated with long-term risk for CVD via similar mechanisms. However, no studies have addressed the potential role of SDB in long-term outcomes of women with GHTN/PE during pregnancy.
   Conclusions Given the suggested mechanisms that explain these associations, it is plausible that SDB during pregnancy may increase long-term cardiovascular morbidity and mortality.
   Relevance Pregnancy may offer a window of opportunity for identification and treatment of SDB, which could provide substantial health benefit for many years to come.
   Target Audience Obstetricians and gynecologists, family physicians
   Learning Objectives After completing this CME activity, physicians should be better able to evaluate the current evidence regarding the frequency of SDB in pregnancy, its risk factors, subsequent outcomes, and treatment.
C1 [Dunietz, Galit Levi] Michigan State Univ, Coll Human Med, Dept Epidemiol & Biostat, E Lansing, MI 48824 USA.
   [Chervin, Ronald David] Univ Michigan, Ann Arbor, MI 48109 USA.
   [O'Brien, Louise Margaret] Univ Michigan, Dept Neurol, Sleep Disorders Ctr, Ann Arbor, MI USA.
   [O'Brien, Louise Margaret] Univ Michigan, Dept Obstet & Gynecol, Ann Arbor, MI 48109 USA.
   [O'Brien, Louise Margaret] Univ Michigan, Dept Oral & Maxillofacial Surg, Ann Arbor, MI 48109 USA.
C3 Michigan State University; Michigan State University College of Human
   Medicine; University of Michigan System; University of Michigan;
   University of Michigan System; University of Michigan; University of
   Michigan System; University of Michigan; University of Michigan System;
   University of Michigan
RP O'Brien, LM (corresponding author), Michael Aldrich Sleep Disorders Lab, C728 Med Inn,Box 5845,1500 East Med Ctr Dr, Ann Arbor, MI 48109 USA.
EM louiseo@med.umich.edu
OI Dunietz, Galit Levi/0000-0002-7240-4923
FU Gene and Tubie Gilmore Fund for Sleep Research; National Heart, Lung,
   and Blood Institute [K23 HL095739]
FX Dr O'Brien was supported in part by the Gene and Tubie Gilmore Fund for
   Sleep Research and the National Heart, Lung, and Blood Institute K23
   HL095739.
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NR 100
TC 20
Z9 24
U1 0
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0029-7828
EI 1533-9866
J9 OBSTET GYNECOL SURV
JI Obstet. Gynecol. Surv.
PD MAR
PY 2014
VL 69
IS 3
BP 164
EP 176
DI 10.1097/OGX.0000000000000052
PG 13
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA AD4WG
UT WOS:000333251400017
PM 25102348
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Iba, T
   Aihara, K
   Yamada, A
   Nagayama, M
   Tabe, Y
   Ohsaka, A
AF Iba, Toshiaki
   Aihara, Koichiro
   Yamada, Atushi
   Nagayama, Masataka
   Tabe, Yoko
   Ohsaka, Akimichi
TI Rivaroxaban attenuates leukocyte adhesion in the microvasculature and
   thrombus formation in an experimental mouse model of type 2 diabetes
   mellitus
SO THROMBOSIS RESEARCH
LA English
DT Article
DE rivaroxaban; Factor Xa inhibitor; type 2 diabetes mellitus;
   leukocyte-endothelial interaction; venous thrombosis
ID FACTOR XA-INHIBITOR; GLYCATION END-PRODUCTS; VENOUS THROMBOEMBOLISM;
   METABOLIC SYNDROME; ENDOTOXEMIC RATS; ENDOTHELIAL DAMAGE; OXIDATIVE
   STRESS; ENOXAPARIN; RAGE; ARTHROPLASTY
AB Introduction: Thrombosis is a major complication in diabetes mellitus. Since Factor Xa inhibitors are not only inhibit the coagulation system but also attenuate the leukocyte-endothelial interaction in acute inflammation models, the purpose of this study is to confirm the similar effects of rivaroxaban in a mouse model of type 2 diabetes mellitus.
   Materials and Methods: In the treatment groups, either 5 or 10 mg/kg of rivaroxaban dissolved in DMSO was orally given to KK-A(y) mice for 7 weeks (n - 6 in each group). KK-A(y) mice fed by chow containing DMSO without rivaroxaban for 7 weeks were served for the control group (n = 6). Following clamping of the mesenteric vein for 20 minutes, intravital microscopic observation of the intestinal microcirculation and the measurement of bleeding time after the needle puncture were carried-out. In another series, the calculation for blood cell counts and the measurement of blood fluidity using micro channel array flow analyzer (MC-FAN) were performed.
   Results: The initial event in the microvasculature is the leukocyte adhesion on endothelium. Then, the leukocytes make clusters and the platelets are involved in. These leukocyte-platelet conjugates aggregate and form thrombus. The leukocyte adherence and the microthrombus formation was significantly suppressed with the treatment of 10 mg/kg of rivaroxaban compared to the control group (P < 0.05). While, the bleeding time was significantly extended with the treatment with 10 mg/kg of rivaroxaban (P < 0.01). The blood fluidity was maintained best with the treatment of 10 mg/kg rivaroxaban.
   Conclusions: Rivaroxaban attenuates the leukocyte-platelet-endothelial interaction, which leads to the attenuation of microthrombus formation in a mouse model of diabetes mellitus. (C) 2013 Elsevier Ltd. All rights reserved.
C1 [Iba, Toshiaki; Aihara, Koichiro; Yamada, Atushi; Nagayama, Masataka] Juntendo Univ, Grad Sch Med, Dept Emergency & Disaster Med, Tokyo, Japan.
   [Tabe, Yoko] Juntendo Univ, Grad Sch Med, Dept Clin Lab Med, Tokyo, Japan.
   [Ohsaka, Akimichi] Juntendo Univ, Grad Sch Med, Dept Transfus Med & Stem Cell Regulat, Tokyo, Japan.
C3 Juntendo University; Juntendo University; Juntendo University
RP Iba, T (corresponding author), 2-1-1 Hongo,Bunkyo Ku, Tokyo 1138421, Japan.
EM toshiiba@cf6.so-net.ne.jp
RI Iba, Toshiaki/H-5314-2013
FU Bayer Health Care
FX This work was financially supported by Bayer Health Care. The authors
   state that they have no other conflict of interest.
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NR 33
TC 22
Z9 25
U1 0
U2 15
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0049-3848
J9 THROMB RES
JI Thromb. Res.
PD FEB
PY 2014
VL 133
IS 2
BP 276
EP 280
DI 10.1016/j.thromres.2013.11.013
PG 5
WC Hematology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Hematology; Cardiovascular System & Cardiology
GA 287WI
UT WOS:000329572600026
PM 24351208
DA 2025-06-11
ER

PT J
AU Rönn, M
   Lind, PM
   Karlsson, H
   Cvek, K
   Berglund, J
   Malmberg, F
   Örberg, J
   Lind, L
   Ortiz-Nieto, F
   Kullberg, J
AF Ronn, Monika
   Lind, P. Monica
   Karlsson, Helen
   Cvek, Katarina
   Berglund, Johan
   Malmberg, Filip
   Orberg, Jan
   Lind, Lars
   Ortiz-Nieto, Francisco
   Kullberg, Joel
TI Quantification of Total and Visceral Adipose Tissue in Fructose-Fed Rats
   Using Water-Fat Separated Single Echo MRI
SO OBESITY
LA English
DT Article
ID PERSISTENT ORGANIC POLLUTANTS; BODY-COMPOSITION ANALYSIS; ENVIRONMENTAL
   OBESOGENS; METABOLIC SYNDROME; ENERGY-BALANCE; OBESE MICE; SEGMENTATION;
   PARTICIPANTS; STRESS; MOUSE
AB Objective: The aim of this study was to setup a rodent model for modest weight gain and an MRI-based quantification of body composition on a clinical 1.5 T MRI system for studies of obesity and environmental factors and their possible association.
   Design and Methods: Twenty-four 4-week-old female Fischer rats were divided into two groups: one exposed group (n=12) and one control group (n 12). The exposed group was given drinking water containing fructose (5% for 7 weeks, then 20% for 3 weeks). The control group was given tap water. Before sacrifice, whole body MRI was performed to determine volumes of total and visceral adipose tissue and lean tissue. MRI was performed using a clinical 1.5 T system and a chemical shift based technique for separation of water and fat signal from a rapid single echo acquisition. Fat signal fraction was used to separate adipose and lean tissue. Visceral adipose tissue volume was quantified using semiautomated segmentation. After sacrifice, a perirenal fat pad and the liver were dissected and weighed. Plasma proteins were analyzed by Western blot.
   Results: The weight gain was 5.2% greater in rats exposed to fructose than in controls (P=0.042). Total and visceral adipose tissue volumes were 5.2 cm(3) (P=0.017) and 3.1 cm(3) (P=0.019) greater, respectively, while lean tissue volumes did not differ. The level of triglycerides and apolipoprotein A-I was higher (P=0.034, P=0.005, respectively) in fructose-exposed rats.
   Conclusions: The setup induced and assessed a modest visceral obesity and hypertriglyceridemia, making it suitable for further studies of a possible association between environmental factors and obesity.
C1 [Ronn, Monika; Lind, P. Monica] Uppsala Univ, Uppsala, Sweden.
   [Karlsson, Helen] Linkoping Univ, Cty Council Ostergotland, Linkoping, Sweden.
   [Cvek, Katarina] Swedish Univ Agr Sci, Dept Clin Sci, Uppsala, Sweden.
   [Berglund, Johan; Ortiz-Nieto, Francisco; Kullberg, Joel] Uppsala Univ, Dept Radiol Oncol & Radiat Sci, Uppsala, Sweden.
   [Malmberg, Filip] Uppsala Univ, Ctr Image Anal, Uppsala, Sweden.
   [Orberg, Jan] Uppsala Univ, Dept Organismal Biol, Uppsala, Sweden.
   [Lind, Lars] Uppsala Univ, Dept Med Sci, Uppsala, Sweden.
C3 Uppsala University; Linkoping University; City Council Ostergotland;
   Swedish University of Agricultural Sciences; Uppsala University; Uppsala
   University; Uppsala University; Uppsala University
RP Kullberg, J (corresponding author), Uppsala Univ, Dept Radiol Oncol & Radiat Sci, Uppsala, Sweden.
EM Joel.Kullberg@radiol.uu.se
RI Kullberg, Joel/ABE-3997-2021; Lind, Lars/KAM-1968-2024; Lind,
   Monica/B-6677-2017; Berglund, Johan/AAW-8679-2020
OI Karlsson, Helen/0000-0002-1620-6180; Berglund, Johan/0000-0002-0853-9305
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NR 35
TC 15
Z9 17
U1 0
U2 23
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1930-7381
EI 1930-739X
J9 OBESITY
JI Obesity
PD SEP
PY 2013
VL 21
IS 9
BP E388
EP E395
DI 10.1002/oby.20229
PG 8
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 231ON
UT WOS:000325426600007
PM 23696386
OA Bronze
DA 2025-06-11
ER

PT J
AU Kumar, H
   Mishra, M
   Bajpai, S
   Pokhria, D
   Arya, AK
   Singh, RK
   Tripathi, K
AF Kumar, Hemant
   Mishra, Manish
   Bajpai, Surabhi
   Pokhria, Deepa
   Arya, Awadhesh Kumar
   Singh, Rakesh Kumar
   Tripathi, Kamlakar
TI Correlation of insulin resistance, beta cell function and insulin
   sensitivity with serum sFas and sFasL in newly diagnosed type 2 diabetes
SO ACTA DIABETOLOGICA
LA English
DT Article
DE sFas; sFas-L; HOMA-IR; HOMA-%S; HOMA-%B
ID NECROSIS-FACTOR-ALPHA; TISSUE LIPOPROTEIN-LIPASE; RECEPTOR SUBSTRATE-1;
   METABOLIC SYNDROME; MUSCLE-CELLS; PHOSPHORYLATION; FAS; ACTIVATION;
   APOPTOSIS; DISEASE
AB Pancreatic beta cell dysfunction and reduced insulin sensitivity are fundamental factors associated with glucotoxicity, lipotoxicity and oxidative stress in type 2 diabetic patients (T2DM). Diabetic milieu can induce apoptosis in several types of cells. The aim of present study was to compare circulating soluble apoptotic markers (sFas and sFas-L) with HOMA-IR, HOMA-%S, HOMA-%B in the serum of newly diagnosed T2DM and healthy subjects. For this study, 94 T2DM and 60 healthy subjects were enroled and evaluated for various parameters. Biochemical quantifications were performed with Syncron CX5 auto-analyzer. The levels of serum sFas-L, TNF-alpha and IL-6 were estimated by flowcytometry. The fasting serum insulin and sFas quantified by ELISA. HOMA-IR, HOMA-%S and HOMA-%B were calculated with HOMA calculator v2.2.2. The levels of TC, TG, LDL-C, VLDL-C were augmented and HDL declined significantly (P < 0.001) in diabetics. The levels of serum insulin, TNF-alpha, IL-6, sFas, HOMA-IR were raised (P < 0.001) and sFas-L, HOMA-%S and HOMA-%B were decreased significantly (P < 0.001) in T2DM subjects than healthy. In diabetics, serum sFas was positively correlated with HOMA-IR (r = 0.720, P < 0.001) and negatively with HOMA-%B (r = -0.642, P < 0.001) significantly while serum sFasL was negatively correlated with HOMA-IR (r = -0.483, P < 0.001) and positively with HOMA-%B (r = 0.466, P < 0.001) significantly. Further, the multivariate stepwise regression analysis shows that HOMA-IR contributes significantly to the variance of sFas and sFasL. Our findings suggest that the pancreatic beta cell dysfunction along with increased insulin resistance appears to be associated with apoptotic markers.
C1 [Kumar, Hemant; Mishra, Manish; Pokhria, Deepa; Arya, Awadhesh Kumar; Tripathi, Kamlakar] Banaras Hindu Univ, Inst Med Sci, Dept Med, Varanasi 221005, Uttar Pradesh, India.
   [Mishra, Manish; Bajpai, Surabhi; Singh, Rakesh Kumar] Banaras Hindu Univ, Fac Sci, Dept Biochem, Varanasi 221005, Uttar Pradesh, India.
C3 Banaras Hindu University (BHU); Banaras Hindu University (BHU)
RP Tripathi, K (corresponding author), Banaras Hindu Univ, Inst Med Sci, Dept Med, Varanasi 221005, Uttar Pradesh, India.
EM kamlakar_tripathi@yahoo.co.in
RI Kumar, Hemant/F-3331-2013; Arya, Awadhesh/L-1867-2019; Singh,
   Rakesh/AAX-9528-2021; Mishra, Manish/AEP-3037-2022; Mishra,
   Manish/ABO-6147-2022
OI Bajpai, Surabhi/0000-0002-2093-7437; Arya, Awadhesh
   Kumar/0000-0002-2142-4924; Mishra, Manish/0000-0003-1620-6022
FU University Grant Commission (UGC), New Delhi under UGC-SRF; University
   Grant Commission (UGC), New Delhi under UGC-DS Kothari Postdoctoral
   scheme; CSIR; ICMR, New Delhi, India
FX Authors HK & MM are thankful to University Grant Commission (UGC), New
   Delhi for providing financial assistance under UGC-SRF and UGC-DS
   Kothari Postdoctoral scheme. Authors SB, AK & DP are grateful to CSIR &
   ICMR, New Delhi, India for fellowship.
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NR 43
TC 19
Z9 22
U1 0
U2 4
PU SPRINGER-VERLAG ITALIA SRL
PI MILAN
PA VIA DECEMBRIO, 28, MILAN, 20137, ITALY
SN 0940-5429
EI 1432-5233
J9 ACTA DIABETOL
JI Acta Diabetol.
PD AUG
PY 2013
VL 50
IS 4
BP 511
EP 518
DI 10.1007/s00592-011-0307-8
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 217AW
UT WOS:000324329900006
PM 21695404
DA 2025-06-11
ER

PT J
AU Popescu, LA
   Vîrgolici, B
   Pacurar, D
   Timnea, O
   Ranetti, AE
   Oraseanu, D
   Zagrean, L
AF Popescu, Laura Anca
   Virgolici, Bogdana
   Pacurar, Daniela
   Timnea, Olivia
   Ranetti, Aurelian Emil
   Oraseanu, Dumitru
   Zagrean, Leon
TI BENEFICIAL EFFECTS OF OMEGA-3 FATTY ACIDS IN NONALCOHOLIC FATTY LIVER
   DISEASE, IN CHILDHOOD OBESITY
SO FARMACIA
LA English
DT Article
DE non-alcoholic fatty liver disease (NAFLD); childhood obesity; Omega-3
   fatty acids; treatment
ID OXIDATIVE STRESS; METABOLIC SYNDROME; CHILDREN; MARKERS; STEATOHEPATITIS
AB Nonalcoholic fatty liver disease (NAFLD) is increasing and is strongly associated with abdominal obesity, dyslipidemia and insulin resistance. To date, there are no proven effective therapies that halt NAFLD progression or improve prognosis in children.
   The aim of this study was to determine the effects of Omega-3 fatty acids (enriched in vitamins) treatment in NAFLD, in obese children.
   Thirty obese children (10-16 years old) and thirty lean children (10-16 years old) were involved. Each day, for three months, obese children took Omega-3 fatty acids (docosahexaenoic acid, DHA 130 mg and eicosapentaenoic acid, EPA 25 mg) and vitamins (A 200 mu g, D 1.25 mu g, E 2.5 mg and C 30 mg). The antropometric markers, lipid profile, inflammatory markers (CRP, ESR, fibrinogen, leptin, ceruloplasmin, albumin/globulin ratio), insulin resistance marker (HOMA-IR), plasminogen activator inhibitor 1 (PAI-1) and liver tests (albumin, bilirubin, protrombin time, ALT, AST) were measured before and after treatment. Ultrasounds were used for NAFLD diagnosis.
   In obese children versus lean subjects all the measured parameters were modified. In obese children, after treatment, lower levels for waist circumference (p<0.05), total colesterol (p<0.02), triglycerides (p<0.01), PAI-1 (p<0.05), ALT and AST activities (p<0.02), HOMA-IR (p<0.005), bilirulin (p<0.02) were measured. After treatment, all the above inflammatory markers (p<0.05) were reduced, while albumin (p<0.05) and calcium (p<0.05) were increased.
   In conclusion, in obese children, treatment with Omega-3 fatty acids, associated with low doses of lipid soluble vitamins and 30 mg of vitamin C, has strong beneficial effects in nonalcoholic fatty liver disease.
C1 [Popescu, Laura Anca; Virgolici, Bogdana; Pacurar, Daniela; Oraseanu, Dumitru; Zagrean, Leon] Carol Davila Univ Med & Pharm, Bucharest, Romania.
   [Pacurar, Daniela; Oraseanu, Dumitru] Clin Pediat Emergency Hosp Grigore Alexandrescu, Bucharest, Romania.
   [Timnea, Olivia] Ecol Univ Bucharest, Fac Phys Educ & Sports, Bucharest, Romania.
   [Ranetti, Aurelian Emil] Cent Mil Hosp Emergency Univ, Dept Endocrinol, Bucharest, Romania.
C3 Carol Davila University of Medicine & Pharmacy; Ecological University of
   Bucharest
RP Ranetti, AE (corresponding author), Cent Mil Hosp Emergency Univ, Dept Endocrinol, Bucharest, Romania.
EM ranetti@gmail.com
RI Timnea, Olivia Carmen/S-2790-2019; Virgolici, Bogdana/MTF-9331-2025;
   Pacurar, Daniela/IYS-1131-2023; Ranetti, Aurelian-Emil/JQV-7664-2023
OI Timnea, Olivia Carmen/0000-0002-7308-5709; Ranetti,
   Aurelian-Emil/0009-0006-1028-0618
FU European Social Fund [POSDRU/89/1.5/S/60746]; Romanian Government
   [POSDRU/107/1.5/S/82839]
FX Popescu Laura Anca, the corresponding author
   (laura_popescuro@yahoo.com), acknowledges the Sectorial Operational
   Programme Human Resources Development (SOP HRD) 2007-2013, financed from
   the European Social Fund and by the Romanian Government under the
   contract number POSDRU/107/1.5/S/82839 Virgolici Bogdana acknowledges
   the postdoctoral program POSDRU/89/1.5/S/60746, from European Social
   Fund.
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NR 26
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U1 0
U2 21
PU SOC STIINTE FARMACEUTICE ROMANIA
PI BUCURESTI
PA BUCURESTI, STR TRAIAN VUIA 6, SECT 1, BUCURESTI, 020956, ROMANIA
SN 0014-8237
EI 2065-0019
J9 FARMACIA
JI Farmacia
PD MAY-JUN
PY 2013
VL 61
IS 3
BP 598
EP 608
PG 11
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 167KM
UT WOS:000320630900018
DA 2025-06-11
ER

PT J
AU Scazzocchio, B
   Varì, R
   D'Archivio, M
   Santangelo, C
   Filesi, C
   Giovannini, C
   Masella, R
AF Scazzocchio, Beatrice
   Vari, Rosaria
   D'Archivio, Massimo
   Santangelo, Carmela
   Filesi, Carmelina
   Giovannini, Claudio
   Masella, Roberta
TI Oxidized LDL impair adipocyte response to insulin by activating
   serine/threonine kinases
SO JOURNAL OF LIPID RESEARCH
LA English
DT Review
DE insulin resistance; GLUT4; IRS-1; IKK beta; NF-kappa B
ID LOW-DENSITY-LIPOPROTEIN; KAPPA-B KINASE; ACUTE CORONARY SYNDROMES; HUMAN
   SKELETAL-MUSCLE; RAT ADIPOSE-CELLS; RECEPTOR SUBSTRATE-1; OXIDATIVE
   STRESS; GLUT4 TRANSLOCATION; 3T3-L1 ADIPOCYTES; TNF-ALPHA
AB Oxidized LDL (oxLDL) increase in patients affected by type-2 diabetes, obesity, and metabolic syndrome. Likewise, insulin resistance, an impaired responsiveness of target tissues to insulin, is associated with those pathological conditions. To investigate a possible causal relationship between oxLDL and the onset of insulin resistance, we evaluated the response to insulin of 3T3-L1 adipocytes treated with oxLDL. We observed that oxLDL inhibited glucose uptake (-40%) through reduced glucose transporter 4 (GLUT4) recruitment to the plasma membrane (-70%), without affecting GLUT4 gene expression. These findings were associated to the impairment of insulin signaling. Specifically, in oxLDL-treated cells insulin receptor (IR) substrate-1 (IRS-1) was highly degraded likely because of the enhanced Ser(307)phosphorylation. This process was largely mediated by the activation of the inhibitor of kappa B-kinase beta (IKK beta) and the c-Jun NH2-terminal kinase (JNK). Moreover, the activation of IKK beta positively regulated the nuclear content of nuclear factor kappa B (NF-kappa B), by inactivating the inhibitor of NF-kappa B (I kappa B alpha). The activated NF-kappa B further impaired per se GLUT4 functionality. Specific inhibitors of IKK beta, JNK, and NF-kappa B restored insulin sensitivity in adipocytes treated with oxLDL. These data provide the first evidence that oxLDL, by activating serine/threonine kinases, impaired adipocyte response to insulin affecting pathways involved in the recruitment of GLUT4 to plasma membranes (PM). jlr This suggests that oxLDL might participate in the development of insulin resistance.-Scazzocchio, B., R. Vari, M. D'Archivio, C. Santangelo, C. Filesi, C. Giovannini, and R. Masella. Oxidized LDL impair adipocyte response to insulin by activating lserine/threonine kinases. J. Lipid Res. 2009. 50: 832-845.
C1 [Scazzocchio, Beatrice; Vari, Rosaria; D'Archivio, Massimo; Santangelo, Carmela; Filesi, Carmelina; Giovannini, Claudio; Masella, Roberta] Ist Super Sanita, Dept Vet Publ Hlth & Food Safety, I-00161 Rome, Italy.
C3 Istituto Superiore di Sanita (ISS)
RP Masella, R (corresponding author), Ist Super Sanita, Dept Vet Publ Hlth & Food Safety, Viale Regina Elena 299, I-00161 Rome, Italy.
EM masellar@iss.it
RI FILESI, CARMELINA/B-4108-2015; scazzocchio, beatrice/B-4110-2015; VARI',
   ROSARIA/B-4111-2015; Masella, Roberta/B-4109-2015; D'Archivio,
   massimo/Z-4633-2019; Giovannini, Claudio/A-9168-2013; SANTANGELO,
   CARMELA/D-5726-2011
OI D'Archivio, Massimo/0000-0001-8104-3421; Masella,
   Roberta/0000-0002-3173-1573; Scazzocchio, Beatrice/0000-0002-5123-3897;
   Giovannini, Claudio/0000-0002-4228-1264; Rosaria,
   Vari/0000-0003-0488-6702; SANTANGELO, CARMELA/0000-0002-4309-1745
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NR 102
TC 39
Z9 44
U1 0
U2 6
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0022-2275
EI 1539-7262
J9 J LIPID RES
JI J. Lipid Res.
PD MAY
PY 2009
VL 50
IS 5
BP 832
EP 845
DI 10.1194/jlr.M800402-JLR200
PG 14
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 430DP
UT WOS:000264969300007
PM 19136667
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Sandu, O
   Song, KY
   Cai, WJ
   Zheng, F
   Uribarri, J
   Vlassara, H
AF Sandu, O
   Song, KY
   Cai, WJ
   Zheng, F
   Uribarri, J
   Vlassara, H
TI Insulin resistance and type 2 diabetes in high-fat-fed mice are linked
   to high glycotoxin intake
SO DIABETES
LA English
DT Article
ID GLYCATION END-PRODUCTS; DIETARY GLYCOTOXINS; METABOLIC SYNDROME;
   OXIDATIVE STRESS; ADVANCED GLYCOSYLATION; RISK-FACTOR; GLYCOXIDATION;
   RECEPTOR; OBESITY; FAILURE
AB Dietary advanced glycosylation end products (AGES) have been linked to insulin resistance in db/db((++)) mice. To test whether dietary AGES play a role in the progression of insulin resistance in normal mice fed high-fat diets, normal C57/BL6 mice were randomly assigned to high-fat diets (35% g fat), either high (HAGE-HF group; 995.4 units/mg AGE) or low (by 2.4-fold LAGE-HF group; 329.6 units/mg AGE) in AGE content for 6 months. Age-matched C57BL6 and db/db((++)) mice fed regular diet (5% g fat, 117.4 units/mg AGE) served as controls. After 6 months, 75% of HAGE-HF mice were diabetic and exhibited higher body weight (P < 0.001), fasting glucose (P < 0.001), insulin (P < 0.001), and serum AGES (P < 0.01) than control mice, while none of the LAGE-HF mice were diabetic despite a similar rise in body weight and plasma lipids. The HAGE-HF group displayed markedly impaired glucose and insulin responses during glucose tolerance tests and euglycemic and hyperglycemic clamps and altered pancreatic islet structure and function compared with those of LAGE-HF mice, in which findings resembled those of control mice. The HAGE-HF group had more visceral fat (by two- and fourfold) and more AGE-modified fat (by two- and fivefold) than LAGE-HF and control mice, respectively. In the HAGE-HF group, plasma 8-isoprostane was higher (P < 0.01) and adiponectin lower (P < 0.001) than control mice, while in the LAGE-HF group, these were more modestly affected (P < 0.05). These results demonstrate that the development of insulin resistance and type 2 diabetes during prolonged high-fat feeding are linked to the excess AGEs/advanced lipoxidation end products inherent in fatty diets.
C1 CUNY Mt Sinai Sch Med, Div Expt Diabet & Aging, Brookdale Dept Geriatr, New York, NY 10029 USA.
   CUNY Mt Sinai Sch Med, Dept Med, Div Nephrol, New York, NY 10029 USA.
C3 Icahn School of Medicine at Mount Sinai; City University of New York
   (CUNY) System; City University of New York (CUNY) System; Icahn School
   of Medicine at Mount Sinai
RP CUNY Mt Sinai Sch Med, Div Expt Diabet & Aging, Brookdale Dept Geriatr, 1 Gustave Levy Pl,Box 1640, New York, NY 10029 USA.
EM helen.vlassara@mssm.edu
RI Uribarri, Jaime/ADX-7655-2022; Sandu, Oana/AAH-4771-2019
OI Sandu, Oana/0000-0002-4198-7249; uribarri, jaime/0000-0001-9826-1134
FU NIA NIH HHS [AG 09453] Funding Source: Medline
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NR 42
TC 164
Z9 180
U1 2
U2 25
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0012-1797
EI 1939-327X
J9 DIABETES
JI Diabetes
PD AUG
PY 2005
VL 54
IS 8
BP 2314
EP 2319
DI 10.2337/diabetes.54.8.2314
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 950PN
UT WOS:000230869500006
PM 16046296
OA Bronze
DA 2025-06-11
ER

PT J
AU Kral, JG
AF Kral, JG
TI Preventing and treating obesity in girls and young women to curb the
   epidemic
SO OBESITY RESEARCH
LA English
DT Article
DE gestational diabetes; catch-up growth; early life stress; imprinting;
   metabolic syndrome
ID IMPAIRED GLUCOSE-TOLERANCE; CHILDHOOD OBESITY; DIABETES-MELLITUS;
   PHYSICAL-ACTIVITY; SUBSEQUENT RISK; GASTRIC BYPASS; FETAL ORIGINS;
   BIRTH-WEIGHT; OVERWEIGHT; PREGNANCY
AB KRAL, JOHN G. Preventing and treating obesity in girls and young women to curb the epidemic. Obes Res. 2004; 12: 1539-1546.
   Obesity and its serious comorbidities, type 2 diabetes, coronary heart disease, hypertension, and dyslipidemia, have reached epidemic proportions in adults and children. Female obesity is more prevalent and, thus, has greater epidemiological importance: Mothers transmit the disease epigenetically and genetically. Maternal obesity affects maternal health, ne, and fetal, neonatal, pregnancy outcome childhood, and ultimately adult morbidity and mortality. Obesity is easy to diagnose, as are most of its risk factors, yet very little progress has been made in preventing the disease.
   During a brief period of rapid early growth, there is imprinting of antecedents of adult obesity and obesity-related disease. Because of the rapidity of this early growth and the relative brevity of the critical period, early recognition and prompt intervention are necessary and possibly sufficient to prevent the development of obesity. Identification of inappropriate rapid weight gain through frequent weighing should trigger immediate adjustment of energy intake, a simple intervention in bottle-fed infants, the ones at greatest risk for becoming, obese.
   This review presents a step-care strategy with fail-safe action levels starting with maternal education and diet, exercise, and behavior modification for mother and child and progressing to drug treatment and. in selected cases, laparoscopic surgery for young women of childbearing age in whom other measures have failed. This approach is predicated on the assumption that careful monitoring and C, responsive supplementation of potential deficiencies is easier to achieve, more cost-effective, and safer than effectively treating manifest obesity and its comorbidities in adults.
C1 Suny Downstate Med Ctr, Dept Surg, Brooklyn, NY 11203 USA.
C3 State University of New York (SUNY) System; SUNY Downstate Health
   Sciences University
RP Suny Downstate Med Ctr, Dept Surg, Box 40,450 Clarkson Ave, Brooklyn, NY 11203 USA.
EM jkral@downstate.edu
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NR 89
TC 51
Z9 55
U1 0
U2 11
PU NORTH AMER ASSOC STUDY OBESITY
PI SILVER SPRING
PA 8630 FENTON ST, SUITE 918, SILVER SPRING, MD 20910 USA
SN 1071-7323
J9 OBES RES
JI Obes. Res.
PD OCT
PY 2004
VL 12
IS 10
BP 1539
EP 1546
DI 10.1038/oby.2004.193
PG 8
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 870XD
UT WOS:000225091200003
PM 15536217
DA 2025-06-11
ER

PT J
AU Sofer, Y
   Osher, E
   Abu Ahmad, W
   Greenman, Y
   Moshe, Y
   Shaklai, S
   Yaron, M
   Serebro, M
   Tordjman, K
   Stern, N
AF Sofer, Yael
   Osher, Esther
   Abu Ahmad, Wiessam
   Greenman, Yona
   Moshe, Yaffa
   Shaklai, Sigal
   Yaron, Marianna
   Serebro, Merav
   Tordjman, Karen
   Stern, Naftali
TI Cortisol Secretion in Obesity Revisited: Lower Basal Serum and Salivary
   Cortisol with Diminished Cortisol Response to the Low Dose ACTH
   Challenge
SO OBESITY FACTS
LA English
DT Article
DE Cortisol; Serum free cortisol; Obesity; Low dose ACTH test
ID PITUITARY-ADRENAL AXIS; 1 MU-G; ABDOMINAL OBESITY; INSULIN-RESISTANCE;
   METABOLIC SYNDROME; FAT DISTRIBUTION; WOMEN; STIMULATION; STRESS; MEN
AB Introduction:Some clinical resemblance may exist betweenobesity, particularly abdominal obesity, and Cushing's syn-drome. This has stimulated ongoing interest in the role ofcortisol's secretion pattern, control, and metabolism inobesity.Goals:The aim of the study was to investigatewhether basal and stimulated levels of cortisol differ be-tween healthy people with obesity and individuals withnormal weight.Methods:Total, free, and salivary cortisolwas tested at baseline state and after 1 mu g ACTH stimulationin 60 healthy subjects with obesity and 54 healthy leancontrols.Results:Baseline total cortisol was lower in subjectswith obesity compared to lean controls (347 [265-452]nmol/L vs. 422 [328-493] nmol/L, respectively;p<0.05).Similarly, basal salivary cortisol was significantly lower insubjects with obesity (7.5 [5.2-9.7] nmol/L vs. 10.7 [7.5-17.6]nmol/L;p<0.05). Upon challenge with ACTH, total peakserum and salivary peak cortisol responses were significantlylower in people with obesity than in lean subjects (665.16 +/- 151.8 vs. 728.64 +/- 124.2 nmol/L;p<0.05 and 31.66[19-38.64] vs. 40.05 [31.46-46.64] nmol/L;p<0.05, re-spectively). Additionally, baseline total cortisol and salivarycortisol were inversely related to BMI (r=-0.24,r=-0.27;p<0.05 for both) and waist circumference (r=-0.27,r=-0.34;p<0.05 for both).Conclusion:Baseline as well as peakstimulated total serum and salivary cortisol were signifi-cantly lower in subjects with obesity. It thus appears thatobesity is not associated with enhanced basal or ACTH-stimulated cortisol.(c) 2025 The Author(s).Published by S. Karger AG, Basel
C1 [Sofer, Yael; Osher, Esther; Greenman, Yona; Moshe, Yaffa; Shaklai, Sigal; Yaron, Marianna; Serebro, Merav; Tordjman, Karen; Stern, Naftali] Sourasky Med Ctr, Inst Endocrinol Metab & Hypertens, Tel Aviv, Israel.
   [Sofer, Yael; Osher, Esther; Greenman, Yona; Shaklai, Sigal; Serebro, Merav; Tordjman, Karen; Stern, Naftali] Tel Aviv Univ, Fac Med, Tel Aviv, Israel.
   [Abu Ahmad, Wiessam] Hebrew Univ Jerusalem Hadassah Hosp & Med Sch, Braun Sch Publ Hlth & Community Med, Jerusalem, Israel.
C3 Tel Aviv University; Sackler Faculty of Medicine; Tel Aviv Sourasky
   Medical Center; Tel Aviv University; Hebrew University of Jerusalem;
   Hadassah University Medical Center; Hadassah University Hospital
RP Sofer, Y (corresponding author), Sourasky Med Ctr, Inst Endocrinol Metab & Hypertens, Tel Aviv, Israel.; Sofer, Y (corresponding author), Tel Aviv Univ, Fac Med, Tel Aviv, Israel.
EM yaelso@tlvmc.gov.il
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NR 44
TC 0
Z9 0
U1 3
U2 3
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1662-4025
EI 1662-4033
J9 OBESITY FACTS
JI Obes. Facts
PD APR
PY 2025
VL 18
IS 2
BP 178
EP 186
DI 10.1159/000543449
EA JAN 2025
PG 9
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 1TR5U
UT WOS:001421197800001
PM 39778537
OA gold
DA 2025-06-11
ER

PT J
AU Zhou, H
   Xu, MM
   Pan, Y
   Wang, SR
   Xu, ZA
   Liu, L
   Liu, XQ
AF Zhou, Hang
   Xu, Mingming
   Pan, Yang
   Wang, Shangren
   Xu, Zhunan
   Liu, Li
   Liu, Xiaoqiang
TI The association between several serum micronutrients and benign
   prostatic hyperplasia: Results from NHANES 2003-2006
SO PROSTATE
LA English
DT Article
DE benign prostatic hyperplasia; micronutrients; NHANES; vitamin
ID URINARY-TRACT SYMPTOMS; ANTIOXIDANT CONCENTRATIONS; METABOLIC SYNDROME;
   OXIDATIVE STRESS; VITAMIN-A; LYCOPENE; CANCER; CAROTENOIDS; PREVENTION;
   EFFICACY
AB BackgroundBenign prostatic hyperplasia (BPH) is a common condition that affects the quality of life of older men. Specific micronutrients, including retinol, retinyl esters, carotenoids, vitamin E, and vitamin C, have antioxidant and anti-inflammatory properties. However, the correlation between serum concentrations of these micronutrients and BPH is unclear.MethodsWe used data from the National Health and Nutrition Examination Survey (NHANES), which included 2067 representative US men. BPH was assessed using the self-reported questionnaire. This association was explored by adjusting for confounders using multivariate logistic regression.ResultsAfter fully adjusting for confounders, for every 0.01 mu mol/L increase in serum retinyl esters, the risk of BPH increased by 2% (OR = 1.02; 95% CI: 1.01-1.03; p = 0.006). Based on the Bonferroni-corrected p-value, we found this correlation to be significant. One mu mol/L increase in total carotenoids was associated with a 22% increase in BPH risk (OR = 1.22; 95% CI: 1.03-1.46; p = 0.025). By analyzing the correlation between different types of carotenoids and BPH, we also found that beta-carotenoids (OR = 1.43; 95% CI: 1.03-1.99; p = 0.036) was also positively correlated with BPH. The subgroup analysis revealed a positive correlation between serum vitamin E (OR = 1.02; 95% CI: 1.00-1.04; p = 0.018) and BPH in men under 60 years of age. Serum retinyl ester (OR = 1.02; 95% CI: 1.01-1.04; p = 0.008) and carotenoid (OR = 1.52; 95% CI: 1.22-1.87; p < 0.001) concentrations were positively correlated with BPH in men over 60 years of age.ConclusionOur study suggests that excessive serum retinyl esters, total carotenoids, and especially beta-carotenoids are potential risk factors for BPH, and this association should be further investigated.
C1 [Zhou, Hang; Xu, Mingming; Pan, Yang; Wang, Shangren; Xu, Zhunan; Liu, Li; Liu, Xiaoqiang] Tianjin Med Univ, Gen Hosp, Dept Urol, 154 Anshan Rd, Tianjin 300052, Peoples R China.
C3 Tianjin Medical University
RP Liu, L; Liu, XQ (corresponding author), Tianjin Med Univ, Gen Hosp, Dept Urol, 154 Anshan Rd, Tianjin 300052, Peoples R China.
EM 18622208373@163.com; xiaoqiangliu1@163.com
RI Zhang, Zhen/GXH-3666-2022
OI Liu, Xiaoqiang/0000-0003-3524-6783
FU This work was supported by the National Natural Science Foundation of
   China (82171594). [82171594]; National Natural Science Foundation of
   China
FX This work was supported by the National Natural Science Foundation of
   China (82171594).
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NR 30
TC 5
Z9 5
U1 0
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0270-4137
EI 1097-0045
J9 PROSTATE
JI Prostate
PD FEB
PY 2024
VL 84
IS 2
BP 212
EP 220
DI 10.1002/pros.24641
EA OCT 2023
PG 9
WC Endocrinology & Metabolism; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Urology & Nephrology
GA GC6T9
UT WOS:001092345500001
PM 37899678
DA 2025-06-11
ER

PT J
AU Gioxari, A
   Amerikanou, C
   Valsamidou, E
   Kleftaki, SA
   Tzavara, C
   Kalaitzopoulou, A
   Stergiou, I
   Smyrnioudis, I
   Kaliora, AC
AF Gioxari, Aristea
   Amerikanou, Charalampia
   Valsamidou, Evdokia
   Kleftaki, Stamatia- Angeliki
   Tzavara, Chara
   Kalaitzopoulou, Aikaterini
   Stergiou, Ioannis
   Smyrnioudis, Ilias
   Kaliora, Adriana C.
TI Chios mastiha essential oil exhibits antihypertensive, hypolipidemic and
   anti-obesity effects in metabolically unhealthy adults - a randomized
   controlled trial
SO PHARMACOLOGICAL RESEARCH
LA English
DT Article
DE Chios Mastiha Essential Oil; Monoterpenes; Obesity; Blood lipids; Blood
   pressure; Inflammation/oxidative stress
ID TYPE-2 DIABETIC-PATIENTS; LEAF EXTRACT; OBESITY; RATS; PROFILE
AB The essential oil of the resinous exudate from Pistacia lentiscus of Chios namely Chios Mastiha Essential Oil (CMEO), is a natural volatile oil rich in monoterpenes alpha-pinene, beta-myrcene, beta-pinene. In the present randomized controlled trial, we investigated the effects of CMEO on individuals with abdominal obesity and metabolic abnormalities i.e., dyslipidemia, hypertension, insulin resistance. Eligible patients (N = 94) were randomly assigned to either the intervention group, receiving capsules containing 200 mg of CMEO daily for 3 months adjunct to current treatment for metabolic disorder(s), or the control group. Anthropometric measurements, blood markers, and quality of life (QoL) were assessed. Statistical analysis was performed on an intention-to-treat basis. A significant improvement in blood lipid profile, namely triglycerides (p = 0.026) and low-density lipoprotein (p = 0.05) of the CMEO group versus controls was observed. Systolic blood pressure (p = 0.05) and alanine aminotransferase (p = 0.022) significantly decreased only after CMEO intake. Alike, weight decreased only in CMEO (p = 0.02), while mean changes in % body fat (p = 0.005) and visceral fat (p = 0.045) were significantly different between groups post-intervention. Lower oxidized LDL (p = 0.044) and higher adiponectin (p = 0.007) were recorded in CMEO with significant different mean changes between groups post-intervention. QoL, as assessed by Short Form-12 questionnaire was improved in the CMEO compared to control (p = 0.041 for Physical Composite Score, p = 0.035 for Mental Composite Score). No adverse effects were reported. An anti-obesity effect of CMEO, probably attributed to modulation of inflammatory and antioxidant processes, is suggested. Conclusively, CMEO can be safe and effective in regulating metabolic abnormalities, adjunct to treatment. (ClinicalTrials.gov. The effect of Mastiha oil in Metabolic Syndrome, ID Number: NCT04785573)
C1 [Gioxari, Aristea] Univ Peloponnese, Sch Hlth Sci, Dept Nutr Sci & Dietet, Kalamata 24100, Messinia, Greece.
   [Amerikanou, Charalampia; Valsamidou, Evdokia; Kleftaki, Stamatia- Angeliki; Tzavara, Chara; Kaliora, Adriana C.] Harokopio Univ, Sch Hlth Sci & Educ, Dept Nutr & Dietet, 70 El Venizelou Ave, Athens 17676, Greece.
   [Kalaitzopoulou, Aikaterini; Stergiou, Ioannis] Gen Hosp G Gennimatas, Diabet Outpatient Dept, Thessaloniki, Greece.
   [Smyrnioudis, Ilias] Mastiha Res Ctr, Chios 82131, Greece.
C3 University of Peloponnese; Harokopio University Athens
RP Kaliora, AC (corresponding author), Harokopio Univ, Sch Hlth Sci & Educ, Dept Nutr & Dietet, 70 El Venizelou Ave, Athens 17676, Greece.
EM akaliora@hua.gr
RI Gioxari, Aristea/AAA-1163-2021; Amerikanou, Charalampia/ABE-1634-2022;
   Kaliora, Andriana/AAM-2912-2021
OI AMERIKANOU, CHARALAMPIA/0000-0002-2014-5392; Kleftaki,
   Matina/0000-0003-2741-2761; Valsamidou, Evdokia/0000-0002-1275-3494;
   Gioxari, Aristea/0000-0002-4869-6815
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NR 70
TC 10
Z9 10
U1 2
U2 8
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 1043-6618
EI 1096-1186
J9 PHARMACOL RES
JI Pharmacol. Res.
PD AUG
PY 2023
VL 194
AR 106821
DI 10.1016/j.phrs.2023.106821
EA JUN 2023
PG 11
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA L8HR0
UT WOS:001025621200001
PM 37329633
OA hybrid
DA 2025-06-11
ER

PT J
AU Tessema, B
   Sack, U
   Koenig, B
   Serebrovska, Z
   Egorov, E
AF Tessema, Belay
   Sack, Ulrich
   Koenig, Brigitte
   Serebrovska, Zoya
   Egorov, Egor
TI Effects of Intermittent Hypoxia in Training Regimes and in Obstructive
   Sleep Apnea on Aging Biomarkers and Age-Related Diseases: A Systematic
   Review
SO FRONTIERS IN AGING NEUROSCIENCE
LA English
DT Review
DE IHNT; IHHT; OSA; aging biomarkers; age-related diseases
ID LEUKOCYTE TELOMERE LENGTH; OXIDATIVE STRESS; OLDER-ADULTS; RESISTANCE;
   ASSOCIATION; QUALITY; LIFE; RISK; ADAPTATIONS; ANTIOXIDANT
AB Several studies have assessed the effects of intermittent hypoxia-normoxia training (IHNT), intermittent hypoxia-hyperoxia training (IHHT), and obstructive sleep apnea (OSA) on aging and age-related diseases in humans; however, the results remain contradictory. Therefore, this review aims to systematically summarize the available studies on the effects of IHNT, IHHT, and OSA on aging and age-related diseases. Relevant studies were searched from PubMed, Google Scholar, Cochrane Library databases, and through manual searching from reference lists of eligible studies. A total of 38 eligible studies were included in this systematic review. IHHT and IHNT provide positive effects on several age-related parameters including quality of life, cognitive and physical functions, plasma level of glucose and cholesterol/LDL, systolic blood pressure, red blood cells, and inflammation. Moreover, moderate intermittent hypoxia induces telomerase reverse transcriptase (TERT) activity and telomere stabilization, delays induction of senescence-associated markers expression and senescence-associated beta-galactosidase, upregulates pluripotent marker (Oct4), activates a metabolic shift, and raises resistance to pro-apoptotic stimuli. On the contrary, intermittent hypoxia in OSA causes hypertension, metabolic syndrome, vascular function impairment, quality of life and cognitive scores reduction, advanced brain aging, increase in insulin resistance, plasma hydrogen peroxide, GSH, IL-6, hsCRP, leptin, and leukocyte telomere shortening. Thus, it can be speculated that the main factor that determines the direction of the intermittent hypoxia action is the intensity and duration of exposure. There is no direct study to prove that IHNT/IHHT actually increases life expectancy in humans. Therefore, further study is needed to investigate the actual effect of IHNT/IHHT on aging in humans.Systematic Review Registration, identifier CRD42022298499.
C1 [Tessema, Belay; Sack, Ulrich] Univ Leipzig, Inst Clin Immunol, Fac Med, Leipzig, Germany.
   [Tessema, Belay; Koenig, Brigitte] Univ Leipzig, Inst Med Microbiol & Epidemiol Infect Dis, Fac Med, Leipzig, Germany.
   [Tessema, Belay] Univ Gondar, Coll Med & Hlth Sci, Dept Med Microbiol, Gondar, Ethiopia.
   [Serebrovska, Zoya] Natl Acad Sci Ukraine, Bogomoletz Inst Physiol, Dept Gen & Mol Pathophysiol, Kiev, Ukraine.
   [Egorov, Egor] IPAM Inst Prevent & Antiaging Med, Berlin, Germany.
C3 Leipzig University; Leipzig University; University of Gondar; National
   Academy of Sciences Ukraine; A.A. Bogomoletz Institute of Physiology
RP Tessema, B (corresponding author), Univ Leipzig, Inst Clin Immunol, Fac Med, Leipzig, Germany.; Tessema, B (corresponding author), Univ Leipzig, Inst Med Microbiol & Epidemiol Infect Dis, Fac Med, Leipzig, Germany.; Tessema, B (corresponding author), Univ Gondar, Coll Med & Hlth Sci, Dept Med Microbiol, Gondar, Ethiopia.
EM bt1488@yahaoo.com
RI Serebrovska, Zoya/AAQ-1549-2021; Sack, Ulrich/J-6301-2015; Tes,
   Bel/L-3858-2019
OI Tessema, Belay/0000-0003-1475-7357
FU InterHypox e.V., Germany; CellAir Construction GmbH
FX The article processing charge was funded by InterHypox e.V., Germany.
   This study received funding from CellAir Construction GmbH. The funder
   was not involved in the study design, collection, analysis,
   interpretation of data, the writing of this article or the decision to
   submit it for publication.
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NR 96
TC 13
Z9 13
U1 1
U2 10
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1663-4365
J9 FRONT AGING NEUROSCI
JI Front. Aging Neurosci.
PD MAY 23
PY 2022
VL 14
AR 878278
DI 10.3389/fnagi.2022.878278
PG 26
WC Geriatrics & Gerontology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology; Neurosciences & Neurology
GA 1X1UU
UT WOS:000807247800001
PM 35677200
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Neve, VV
   Undale, V
   Bhalchim, V
   Shinde, A
   Patil, G
   Kutal, P
AF Neve, Vrushali V.
   Undale, Vaishali
   Bhalchim, Vrushali
   Shinde, Ankita
   Patil, Gauri
   Kutal, Pritam
TI Combine Impact of Shatavari and Shatpushpi on Polycyclic ovarian
   syndrome (PCOS)
SO JOURNAL OF PHARMACEUTICAL NEGATIVE RESULTS
LA English
DT Article
DE Polycystic ovary syndrome; Shatavari; Shatpushpi; Hyperandrogenism;
   Anovulation; hormonal imbalance; Cortisol; Oocyte; Ovary
ID MEDICINAL-PLANTS
AB Background: Polycystic ovary syndrome (PCOS) is one of the common disorder in female. Polycystic ovary syndrome causes irregular menstrual cycles, excessive body or facial hair and polycystic ovaries as its main symptoms. Polycystic means "many cysts," and PCOS often causes clusters of small, pearl-sized cysts in the ovaries. The cysts are fluid-filled and contain immature eggs. Women with PCOS produce higher amounts of androgens a male hormones, which leads to some of the symptoms of PCOS. PCOS is an emerging lot of health problem during adolescence therefore promotion of healthy lifestyles and early interventions are required to prevent future morbidities. Stress is one of the factor that deeply rooted in the society and women are most frequently exposed to psychological, physical and physiological stressors. PCOS cannot be prevented, but early diagnosis and treatment helps to prevent long-term complications, such as infertility, diabetes , obesity, metabolic syndrome and some heart disease. In India , prevalence rate of PCOS is higher and most of the cases reported in Maharashtra (22% upto year 2020) as compared to other state of India. Main body:Shatavari and Shatpushpi both are used as tonic for female reproductive system. Effectiveness of combination of Shatavari and Shatpushi is utilize in treatment of PCOS.Overactive pituitary gland start to secreat high amount of luitenizing hormone in bloodstream which disrupt normal menstrual cycle due to which follicle does not mature and ovulation does not takes place. As because of irregular ovulation hormonal imbalance occur and that leads to increase secrestion of testosterone. High level of testosterone leads to infertility Conclusion: This review describe that easily available beneficial herbs, Shatavari and Shatpushi along with lifestyle management is much effective in prevention of PCOS than allopathic treatment which have large side effects.
C1 [Neve, Vrushali V.; Undale, Vaishali; Bhalchim, Vrushali; Shinde, Ankita; Patil, Gauri; Kutal, Pritam] Dr DY Patil Inst Pharmaceut Sci & Res, Pune 411018, Maharshtra, India.
RP Neve, VV (corresponding author), Dr DY Patil Inst Pharmaceut Sci & Res, Pune 411018, Maharshtra, India.
EM vrushalivneve@gmail.com
RI Patil, Gauri/KLC-3716-2024
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NR 20
TC 0
Z9 0
U1 0
U2 2
PU RESEARCHTRENTZ ACAD PUBL EDUCATION SERVICES
PI Somerville
PA 240 Elm Street, 2nd & 3rd Floors, Somerville, MA, UNITED STATES
SN 0976-9234
EI 2229-7723
J9 J PHARM NEGAT RESULT
JI J. Pharm. Negat. Results
PY 2022
VL 13
SI SI
BP 431
EP 437
DI 10.47750/pnr.2022.13.S06.060
PG 7
WC Pharmacology & Pharmacy
WE Emerging Sources Citation Index (ESCI)
SC Pharmacology & Pharmacy
GA 5T8GS
UT WOS:000876098200007
DA 2025-06-11
ER

PT J
AU Sheikhhossein, F
   Amini, MR
   Shahinfar, H
   Djafari, F
   Safabakhsh, M
   Shab-Bidar, S
AF Sheikhhossein, Fatemeh
   Amini, Mohammad Reza
   Shahinfar, Hossein
   Djafari, Farhang
   Safabakhsh, Maryam
   Shab-Bidar, Sakineh
TI Effects of chromium supplementation on inflammatory biomarkers: A
   systematic review and dose-response meta-analysis of randomized
   controlled trials
SO EUROPEAN JOURNAL OF INTEGRATIVE MEDICINE
LA English
DT Review
DE Chromium; Supplementation; Inflammation; Meta-analysis; Systematic
   review; Inflammatory biomarkers; C- reactive protein
ID TYPE-2 DIABETIC SUBJECTS; C-REACTIVE PROTEIN; OXIDATIVE STRESS;
   DOUBLE-BLIND; DINICOCYSTEINATE SUPPLEMENTATION; CARDIOVASCULAR-DISEASE;
   LIPID-PEROXIDATION; INSULIN-RESISTANCE; METABOLIC SYNDROME; TNF-ALPHA
AB Introduction: Accumulating evidence suggests that chromium (Cr) supplementation may prevent inflammation, however, the results have been inconsistent. To derive a more precise estimation of the efficacy of Cr supplementation on inflammatory mediators such as tumor necrosis factor-alpha (TNF-alpha), high-sensitivity C-reactive protein (hs-CRP), and interleukin-6 (IL-6), this systematic review and meta-analysis was performed.
   Methods: An advanced search of PubMed and Scopus was conducted from inception to 14 April 2020 to find randomized controlled trials that assessed the effect of Cr supplementation on inflammation among the adult population.
   Results: The search resulted in identifying 10 articles which met the inclusion criteria for the systematic review. Our results indicated that Cr supplementation significantly decreased serum levels of hs-CRP (weighted mean differences (WMD): -0.95 mg/l; 95 % CI, -1.54 to -0.36, P = 0.002). Greater effects on hs-CRP were detected in trials using Cr picolinate and Cr chloride, dosage < 300 mu g with duration <= 12 weeks. Also, 12 weeks supplementation with Cr dinicocysteinate led to a significant reduction in the level of TNF-alpha but Cr picolinate did not show significant changes in serum levels of TNF-alpha. Moreover, both Cr picolinate and Cr dinicocysteinate had no significant differences in the level of serum IL-6 and IL-8. Although, a significant non-linear association was found between serum hs-CRP changes and study duration (Pnon-linearity = 0.03), we did not find any significant association between serum hs-CRP changes and dosage (Pnon-linearity = 0.86) with Cr picolinate supplementation.
   Conclusion: Supplementation with Cr picolinate and Cr chloride at dose < 300 mu g for <= 12 weeks could significantly decrease serum hs-CRP levels.
C1 [Sheikhhossein, Fatemeh] Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Clin Nutr, Tehran, Iran.
   [Sheikhhossein, Fatemeh] Univ Tehran Med Sci, Students Sci Res Ctr SSRC, Tehran, Iran.
   [Amini, Mohammad Reza; Shahinfar, Hossein; Djafari, Farhang; Safabakhsh, Maryam; Shab-Bidar, Sakineh] Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Community Nutr, 44 Hojjat Dost Alley,Naderi St,Keshavarz Blvd, Tehran, Iran.
C3 Tehran University of Medical Sciences; Tehran University of Medical
   Sciences; Tehran University of Medical Sciences
RP Shab-Bidar, S (corresponding author), Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Community Nutr, 44 Hojjat Dost Alley,Naderi St,Keshavarz Blvd, Tehran, Iran.
EM s_shabbidar@tums.ac.ir
RI Amini, Mohammad/ABD-9638-2020; Shab-Bidar, Sakineh/H-9525-2017;
   Shahinfar, Hossein/ABF-9212-2020
OI Amini, Mohammad Reza/0000-0003-0640-2142; Shahinfar,
   Hossein/0000-0002-4499-4102
CR [Anonymous], 2018, LOCAL POLYNOMIAL MOD
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NR 36
TC 9
Z9 9
U1 0
U2 4
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1876-3820
EI 1876-3839
J9 EUR J INTEGR MED
JI Eur. J. Integr. Med.
PD AUG
PY 2020
VL 37
AR 101147
DI 10.1016/j.eujim.2020.101147
PG 7
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA NN3VU
UT WOS:000568719700013
DA 2025-06-11
ER

PT J
AU Zhang, XZ
   Tu, WJ
   Wang, H
   Zhao, Q
   Liu, Q
   Sun, L
   Yu, L
AF Zhang, Xian-Zhao
   Tu, Wen-Jun
   Wang, Hong
   Zhao, Qi
   Liu, Qiang
   Sun, Lei
   Yu, Lei
TI Circulating Serum Fatty Acid-Binding Protein 4 Levels Predict the
   Development of Diabetic Retinopathy in Type 2 Diabetic Patients
SO AMERICAN JOURNAL OF OPHTHALMOLOGY
LA English
DT Article
ID ENDOPLASMIC-RETICULUM STRESS; INSULIN-RESISTANCE; CHINESE PATIENTS;
   CAROTID ATHEROSCLEROSIS; METABOLIC SYNDROME; PATHOGENESIS; PROGRESSION;
   BIOMARKER; MELLITUS; LIPOPROTEIN(A)
AB PURPOSE: Fatty acid-binding protein 4 (FABP4) has been implicated in the pathology of diabetes and macro vascular diseases. Serum FABP4 levels were determined in type 2 diabetic patients without diabetic retinopathy (DR) at admission in order to investigate a possible contribution of FABP4 to the increased risk of 5-year incidence of DR.
   DESIGN: Cohort study.
   METHODS: A total of 738 patients with type 2 diabetes without DR were consecutively enrolled and followed up prospectively. Retinopathy evaluation was annually performed by ophthalmologists in the following 5 years. Multivariate analyses were performed using logistic regression models.
   RESULTS: During the follow-up period, 152 (20.60% [95% CI: 17.68%-23.51%]) patients developed DR and 60 (8.13% [95% CI: 6.16%-10.10%]) patients developed vision-threatening DR (VTDR). Nonparametric Spearman rank correlation revealed a statistically significant positive correlation between serum FABP 4 level and international Clinical Diabetic Retinopathy Severity Scales (r = 0.348; P <.001). After adjustment for other established risk factors, in multivariate models comparing the third and fourth quartiles against the first quartile of the FABP4, levels of FABP4 were associated with DR and the adjusted risk of DR increased by 124% (OR = 2.24 [95% CI 1.65-3.68], P =.006) and 227% (3.27 [2.04-5.56], P <.001), respectively. Similarly, the adjusted risk of VTDR increased by 140% (OR = 2.40 [95% CI 1.32-3.82], P =.001) and 278% (3.78 [2.17-6.59], P <.001), respectively.
   CONCLUSION: FABP4 shows potential as a novel biomarker for DR prediction in Chinese patients with T2DM, and strict glycemic control and more frequent retinal examination should be highlighted for T2DM patients with the highest quartile range of FABP4. (C) 2017 Elsevier Inc. All rights reserved.
C1 [Zhang, Xian-Zhao] Linyi Peoples Hosp, Dept Cardiol, Linyi, Peoples R China.
   [Tu, Wen-Jun; Wang, Hong; Liu, Qiang] China Acad Med Sci, Inst Radiat Med, Tianjin, Peoples R China.
   [Tu, Wen-Jun; Wang, Hong; Liu, Qiang] Peking Union Med Coll, Tianjin, Peoples R China.
   [Tu, Wen-Jun] Capital Med Univ, Dept Lab, Beijing Rehabil Hosp, Beijing, Peoples R China.
   [Zhao, Qi] Dalian Med Univ, Dept Endocrinol, Hosp 2, Dalian, Peoples R China.
   [Sun, Lei; Yu, Lei] Harbin Med Univ, Dept Ophthalmol, Affiliated Hosp 4, Harbin, Heilongjiang, Peoples R China.
C3 Chinese Academy of Medical Sciences - Peking Union Medical College;
   Institute of Radiation Medicine - CAMS; Chinese Academy of Medical
   Sciences - Peking Union Medical College; Peking Union Medical College;
   Capital Medical University; Dalian Medical University; Harbin Medical
   University
RP Liu, Q (corresponding author), 238 Baiti Rd, Tianjin 300192, Peoples R China.; Sun, L (corresponding author), 37 Yiyuan St, Harbin 150001, Heilongjiang, Peoples R China.
EM liuqiang_cams@163.com; sunharmu@163.com
RI Tu, Wen-Jun/AAC-5696-2019; Wang, Hong/HIK-3347-2022; Liu,
   Qiang/AFK-6590-2022
OI YU, LEI/0000-0002-8837-2022; Wang, Hong/0000-0002-1300-9595; Liu,
   Qiang/0000-0002-7668-6868
FU NATIONAL NATURAL SCIENCE FOUNDATION OF HEILONGJIANG (Harbin)
   [2010HLJ10A006]; CAMS Innovation Fund for Medical Science (Beijing)
   [2017-I2M-1-016]
FX THIS STUDY WAS SUPPORTED BY THE NATIONAL NATURAL SCIENCE FOUNDATION OF
   HEILONGJIANG (Harbin; 2010HLJ10A006) and CAMS Innovation Fund for
   Medical Science (Beijing; No. 2017-I2M-1-016).
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NR 44
TC 16
Z9 17
U1 0
U2 9
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0002-9394
EI 1879-1891
J9 AM J OPHTHALMOL
JI Am. J. Ophthalmol.
PD MAR
PY 2018
VL 187
BP 71
EP 79
DI 10.1016/j.ajo.2017.12.022
PG 9
WC Ophthalmology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Ophthalmology
GA FZ1IP
UT WOS:000427330400013
PM 29305311
DA 2025-06-11
ER

PT J
AU Guimaraes, KSL
   de Araújo, EV
   Aquino, JS
   Gadelha, DA
   Balarini, CM
   Costa-Silva, JH
   Magnani, M
   Vidal, H
   Braga, VA
   Alves, JLD
AF Guimaraes, Keyth Sulamitta L.
   de Araujo, Emmanuel Verissimo
   Aquino, Jailane Souza
   Gadelha, Danilo Assis
   Balarini, Camille Moura
   Costa-Silva, Joao Henrique
   Magnani, Marciane
   Vidal, Hubert
   Braga, Valdir Andrade
   de Brito Alves, Jose Luiz
TI Effect of maternal dyslipidaemia on the cardiorespiratory physiology and
   biochemical parameters in male rat offspring
SO BRITISH JOURNAL OF NUTRITION
LA English
DT Article
DE Maternal dyslipidaemia; Biochemical parameters; Hypertension;
   Chemosensitivity
ID HIGH-FAT DIET; CHRONIC INTERMITTENT HYPOXIA; SYMPATHETIC-NERVOUS-SYSTEM;
   LOW-PROTEIN DIET; OXIDATIVE STRESS; BAROREFLEX SENSITIVITY; LACTATION
   PROMOTES; METABOLIC SYNDROME; HYPERTENSIVE-RATS; PERINATAL-PERIOD
AB The present study evaluated the effects of maternal dyslipidaemia on blood pressure (BP), cardiorespiratory physiology and biochemical parameters in male offspring. Wistar rat dams were fed either a control (CTL) or a dyslipidaemic (DLP) diet during pregnancy and lactation. After weaning, both CTL and DLP offspring received standard diet. On the 30th and 90th day of life, blood samples were collected for metabolic analyses. Direct measurements of BP, respiratory frequency (R-F), tidal volume (V-T) and ventilation (V-E) under baseline condition, as well as during hypercapnia (7 % CO2) and hypoxia (KCN, 0.04 %), were recorded from awake 90-d-old male offspring. DLP dams exhibited raised serum levels of total cholesterol (TC) (4.0-fold), TAG (2.0-fold), VLDL+LDL (7.7-fold) and reduced HDL-cholesterol (2.4-fold), insulin resistance and hepatic steatosis at the end of lactation. At 30 d of age, the DLP offspring showed an increase in the serum levels of TC (P < 0.05) and VLDL+LDL (P < 0.05) in comparison with CTL offspring. At 90 d of age, DLP offspring exhibited higher mean arterial pressure (MAP, approximately 34 %). In the spectral analysis, the DLP group showed augmented low-frequency (LF) power and LF:high-frequency (HF) ratio when compared with CTL offspring. In addition, the DLP animals showed a larger delta variation in arterial pressure after administration of the ganglionic blocker (P = 0.0003). We also found that cardiorespiratory response to hypercapnia and hypoxia was augmented in DLP offspring. In conclusion, the present data show that maternal dyslipidaemia alters cardiorespiratory physiology and may be a predisposing factor for hypertension at adulthood.
C1 [Guimaraes, Keyth Sulamitta L.; de Araujo, Emmanuel Verissimo; Aquino, Jailane Souza; de Brito Alves, Jose Luiz] Univ Fed Paraiba, Hlth Sci Ctr, Dept Nutr, BR-58051900 Joao Pessoa, Paraiba, Brazil.
   [Gadelha, Danilo Assis; Balarini, Camille Moura; Braga, Valdir Andrade] Univ Fed Paraiba, Biotechnol Ctr, BR-58051900 Joao Pessoa, Paraiba, Brazil.
   [Balarini, Camille Moura] Univ Fed Paraiba, Hlth Sci Ctr, Dept Physiol & Pathol, BR-58051900 Joao Pessoa, Paraiba, Brazil.
   [Costa-Silva, Joao Henrique] Univ Fed Paraiba, Dept Phys Educ & Sport Sci, BR-55608680 Vitoria De Santo Antao, PE, Brazil.
   [Magnani, Marciane] Univ Fed Paraiba, Technol Ctr, Dept Food Engn, BR-58051900 Joao Pessoa, Paraiba, Brazil.
   [Vidal, Hubert; de Brito Alves, Jose Luiz] Univ Lyon, Univ Claude Bernard Lyon 1, INSERM U1060,INSA Lyon, CarMeN Cardio Metab Diabet & Nutr Lab,INRA,U1397, F-69600 Oullins, France.
C3 Universidade Federal da Paraiba; Universidade Federal da Paraiba;
   Universidade Federal da Paraiba; Universidade Federal da Paraiba;
   Universidade Federal da Paraiba; Institut National des Sciences
   Appliquees de Lyon - INSA Lyon; Universite Claude Bernard Lyon 1; INRAE;
   Institut National de la Sante et de la Recherche Medicale (Inserm)
RP Alves, JLD (corresponding author), Univ Fed Paraiba, Hlth Sci Ctr, Dept Nutr, BR-58051900 Joao Pessoa, Paraiba, Brazil.; Alves, JLD (corresponding author), Univ Lyon, Univ Claude Bernard Lyon 1, INSERM U1060,INSA Lyon, CarMeN Cardio Metab Diabet & Nutr Lab,INRA,U1397, F-69600 Oullins, France.
EM jose_luiz_61@hotmail.com
RI Costa-Silva, João Henrique/D-1372-2014; Araujo, Emmanuel/MGU-7602-2025;
   Braga, Valdir/K-7899-2012; De Brito Alves, José/R-7175-2017; Magnani,
   Marciane/P-4265-2016; VIDAL, Hubert/M-6674-2017
OI Verissimo de Araujo, Emmanuel/0000-0002-1388-2722; de Brito Alves, Jose
   Luiz/0000-0003-4696-3809; Costa-Silva, Joao
   Henrique/0000-0002-9794-1418; de Souza Aquino,
   Jailane/0000-0002-7221-9867; Lab, Carmen/0000-0002-5935-3236; Carmen,
   Team1/0000-0003-4234-1746; de Andrade Braga, Valdir/0000-0002-6484-6203;
   Magnani, Marciane/0000-0002-7771-0479; VIDAL, Hubert/0000-0002-9467-0317
FU CNPq Fellowship
FX V. A. B. and M. M. are recipients of the CNPq Fellowship.
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NR 51
TC 16
Z9 17
U1 0
U2 10
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1145
EI 1475-2662
J9 BRIT J NUTR
JI Br. J. Nutr.
PD DEC 14
PY 2017
VL 118
IS 11
BP 930
EP 941
DI 10.1017/S0007114517003014
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA FP3PI
UT WOS:000417529700007
PM 29173205
OA Bronze
DA 2025-06-11
ER

PT J
AU Barbeau, PA
   Holloway, TM
   Whitfield, J
   Baechler, BL
   Quadrilatero, J
   van Loon, LJC
   Chabowski, A
   Holloway, GP
AF Barbeau, Pierre-Andre
   Holloway, Tanya M.
   Whitfield, Jamie
   Baechler, Brittany L.
   Quadrilatero, Joe
   van Loon, Luc J. C.
   Chabowski, Adrian
   Holloway, Graham P.
TI α-Linolenic acid and exercise training independently, and additively,
   decrease blood pressure and prevent diastolic dysfunction in obese
   Zucker rats
SO JOURNAL OF PHYSIOLOGY-LONDON
LA English
DT Article
DE angiogenesis; diabetic cardiomyopathy; exercise physiology; heart; PUFA
ID CORONARY-HEART-DISEASE; N-3 FATTY-ACIDS; DIABETIC CARDIOMYOPATHY;
   METABOLIC SYNDROME; LIPID PROFILE; FISH-OIL; MITOCHONDRIAL BIOGENESIS;
   INSULIN-RESISTANCE; SERUM-CHOLESTEROL; PHYSICAL-EXERCISE
AB Although alpha-linolenic acid (ALA) and endurance exercise training independently attenuate hyperlipidaemia-related cardiovascular derangements, there is a paucity of information pertaining to their mechanisms of action and efficacy when combined as a preventative therapeutic approach. Therefore, we used obese Zucker rats to investigate the independent and combined effects of these interventions on cardiovascular disease. Specifically, animals were randomly assigned to one of the following groups: control diet-sedentary, ALA supplemented-sedentary, control diet-exercise trained or ALA supplemented-exercise trained. Following a 4week intervention, although the independent and combined effects of ALA and exercise reduced (P<0.05) the serum free/esterified cholesterol ratio, only the ALA supplemented-exercise trained animals displayed a reduction in the content of both serum free and esterified cholesterol. Moreover, although ALA and endurance training individually increased cardiac output, stroke volume and end-diastolic volume, as well as reduced left ventricle fibrosis, mean blood pressure and total peripheral resistance, these responses were all greater following the combined intervention (ALA supplemented-exercise trained). These effects occurred independent of changes in oxidative phosphorylation proteins, markers of oxidative stress or endogenous anti-oxidant capacity. We propose that the beneficial effects of a combined intervention occur as a result of divergent mechanisms of action elicited by ALA and endurance exercise because only exercise training increased the capillary content in the left ventricle and skeletal muscle, and tended to decrease protein carbonylation in the left ventricle (P=0.06). Taken together, our data indicate that combining ALA and endurance exercise provides additional improvements in cardiovascular disease risk reduction compared to singular interventions in the obese Zucker rat.
C1 [Barbeau, Pierre-Andre; Holloway, Tanya M.; Whitfield, Jamie; Holloway, Graham P.] Univ Guelph, Human Hlth & Nutr Sci, Guelph, ON, Canada.
   [Holloway, Tanya M.; van Loon, Luc J. C.] Maastricht Univ, NUTRIM Sch Nutr & Translat Res Metab, Med Ctr, Maastricht, Netherlands.
   [Baechler, Brittany L.; Quadrilatero, Joe] Univ Waterloo, Dept Kinesiol, Waterloo, ON, Canada.
   [Chabowski, Adrian] Med Univ Bialystok, Dept Physiol, Bialystok, Poland.
C3 University of Guelph; Maastricht University; Maastricht University
   Medical Centre (MUMC); University of Waterloo; Medical University of
   Bialystok
RP Holloway, GP (corresponding author), Univ Guelph, Dept Human Hlth & Nutr Sci, Guelph, ON N1L 0A5, Canada.
EM ghollowa@uoguelph.ca
RI Whitfield, Jamie/J-1570-2018; van Loon, Luc J.C./G-5920-2010; Chabowski,
   Adrian/T-2225-2018
OI Whitfield, Jamie/0000-0002-8961-8872; van Loon, Luc
   J.C./0000-0002-6768-9231; Chabowski, Adrian/0000-0002-7407-8156
FU Natural Sciences and Engineering Research Council of Canada (NSERC)
FX This research was funded by the Natural Sciences and Engineering
   Research Council of Canada (NSERC).
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NR 57
TC 16
Z9 16
U1 0
U2 24
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-3751
EI 1469-7793
J9 J PHYSIOL-LONDON
JI J. Physiol.-London
PD JUL 1
PY 2017
VL 595
IS 13
BP 4351
EP 4364
DI 10.1113/JP274036
PG 14
WC Neurosciences; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Physiology
GA EZ4BH
UT WOS:000404655400025
PM 28345766
OA Green Published
DA 2025-06-11
ER

PT J
AU Ma, SB
   Zhang, R
   Miao, S
   Gao, B
   Lu, Y
   Hui, S
   Li, L
   Shi, XP
   Wen, AD
AF Ma, Shan-Bo
   Zhang, Rui
   Miao, Shan
   Gao, Bin
   Lu, Yang
   Hui, Sen
   Li, Long
   Shi, Xiao-Peng
   Wen, Ai-Dong
TI Epigallocatechin-3-gallate ameliorates insulin resistance in hepatocytes
SO MOLECULAR MEDICINE REPORTS
LA English
DT Article
DE epigallocatechin-3-gallate; reactive oxygen species; c-JUN N-terminal
   kinase/insulin receptor substrate 1/protein kinase B/glycogen synthase
   kinase signaling pathway; insulin resistance
ID GREEN TEA CATECHINS; METABOLIC SYNDROME; OXIDATIVE STRESS;
   DIABETES-MELLITUS; MICE; EGCG; POLYPHENOLS; ADIPOCYTES; PREVENTION;
   PATHWAYS
AB Hyperglycemia is a typical pathogenic factor in a series of complications among patients with type II diabetes. Epigallocatechin-3-gallate (EGCG) is the major polyphenol extracted from green tea and is reported to be an antioxidant. The aim of the present study was to examine the effect of EGCG on insulin resistance in human HepG2 cells pretreated with high concentrations of glucose. The protein kinase B (AKT)/glycogen synthase kinase (GSK) pathways were analyzed using western blot analysis in HepG2 cells and primary mouse hepatocytes treated with high glucose and/or EGCG. Cellular glycogen content was determined using a glycogen assay kit. Reactive oxygen species (ROS) production was determined using dihydroethidium staining and flow cytometry. c-JUN N-terminal kinase (JNK)/insulin receptor substrate 1 (IRS1)/AKT/GSK signaling was explored using western blot analysis in HepG2 cells treated with high glucose and/or EGCG or N-acetyl-cysteine. High glucose significantly decreased the levels of phosphorylated AKT and GSK in HepG2 cells and mouse primary hepatocytes. Pretreatment with EGCG significantly restored the activation of AKT and GSK in HepG2 cells and primary hepatocytes exposed to high glucose. In HepG2 cells and primary hepatocytes, glycogen synthesis was improved by EGCG treatment in a dose-dependent manner. High glucose significantly stimulated the production of ROS while EGCG protected high glucose-induced ROS production. ROS is known to serve a major role in high glucose induced-insulin resistance by increasing JNK and IRS1 serine phosphorylation. In the present study, EGCG was observed to enhance the insulin-signaling pathway. EGCG ameliorated high glucose-induced insulin resistance in the hepatocytes by potentially decreasing ROS-induced JNK/IRS1/AKT/GSK signaling.
C1 [Ma, Shan-Bo; Lu, Yang; Hui, Sen; Li, Long; Shi, Xiao-Peng; Wen, Ai-Dong] Fourth Mil Med Univ, Xijing Hosp, Dept Pharm, 127 Chang Le West Rd, Xian 710032, Shaanxi, Peoples R China.
   [Zhang, Rui] Fourth Mil Med Univ, Dept Otolaryngol Head & Neck Surg, Xijing Hosp, Xian 710032, Shaanxi, Peoples R China.
   [Miao, Shan] Fourth Mil Med Univ, Inst Med Mat, Xian 710032, Shaanxi, Peoples R China.
   [Gao, Bin] Fourth Mil Med Univ, Xijing Hosp, Dept Endocrinol, Xian 710032, Shaanxi, Peoples R China.
C3 Air Force Medical University; Air Force Medical University; Air Force
   Medical University; Air Force Medical University
RP Shi, XP; Wen, AD (corresponding author), Fourth Mil Med Univ, Xijing Hosp, Dept Pharm, 127 Chang Le West Rd, Xian 710032, Shaanxi, Peoples R China.
EM shixiaop@fmmu.edu.cn; adwen-2004@hotmail.com
RI Wen, Aidong/P-2654-2019; gao, bin/JYW-5418-2024; Wen, Aidong/I-5009-2017
OI Wen, Aidong/0000-0002-4535-0501
CR Basu A, 2010, J AM COLL NUTR, V29, P31, DOI 10.1080/07315724.2010.10719814
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NR 35
TC 16
Z9 18
U1 2
U2 22
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1791-2997
EI 1791-3004
J9 MOL MED REP
JI Mol. Med. Rep.
PD JUN
PY 2017
VL 15
IS 6
BP 3803
EP 3809
DI 10.3892/mmr.2017.6450
PG 7
WC Oncology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Research & Experimental Medicine
GA EU5LA
UT WOS:000401071600049
PM 28393248
OA Bronze
DA 2025-06-11
ER

PT J
AU Aloud, BM
   Raj, P
   O'Hara, K
   Shao, ZJ
   Yu, LP
   Anderson, HD
   Netticadan, T
AF Aloud, Basma Milad
   Raj, Pema
   O'Hara, Kimberley
   Shao, Zongjun
   Yu, Liping
   Anderson, Hope D.
   Netticadan, Thomas
TI Conjugated linoleic acid prevents high glucose-induced hypertrophy and
   contractile dysfunction in adult rat cardiomyocytes
SO NUTRITION RESEARCH
LA English
DT Article
DE Conjugated linoleic acid; Diabetic cardiomyopathy; Cardiomyocytes;
   Hyperglycemia; Contractile dysfunction; Cardiomyocyte hypertrophy; Rats
ID VENTRICULAR DIASTOLIC DYSFUNCTION; CARDIAC MYOCYTE HYPERTROPHY;
   ACTIVATED-RECEPTOR-ALPHA; WHITE ADIPOSE-TISSUE; OXIDATIVE STRESS;
   DIACYLGLYCEROL KINASE; METABOLIC SYNDROME; DIABETIC-RATS; IN-VITRO;
   GAMMA
AB Diabetes mellitus is associated with increased risk and incidence of cardiovascular morbidity and mortality, independently of other risk factors typically associated with diabetes such as coronary artery disease and hypertension. This promotes the development of a distinct condition of the heart muscle known as diabetic cardiomyopathy. We have previously shown that conjugated linoleic acid (CLA) prevents endothelin-1-induced cardiomyocyte hypertrophy. However, the effects of CLA in preventing alterations in cardiomyocyte structure and function due to high glucose are unknown. We therefore hypothesized that CLA will have protective effects in an in vitro model of diabetic cardiomyopathy using adult rat cardiomyocytes exposed to high glucose. Our results demonstrate that subjecting adult rat cardiomyocytes to high glucose (25 mmol/L) for 24 hours significantly impaired the contractile function as evidenced by decreases in maximal velocity of shortening, peak shortening, and maximal velocity of relengthening. High glucose induced contractile dysfunction was inhibited by pretreatment with CIA (30 mu mol/L; 1 hour). In addition to contractile aberrations, exposing adult rat cardiomyocytes to high glucose for 48 hours induced cardiomyocyte hypertrophy. High glucose-induced cardiomyocyte hypertrophy was likewise prevented by CLA. The antihypertrophic effects of CIA were abolished when cardiomyocytes were pretreated with the pharmacologic inhibitor of peroxisome proliferator-activated receptor gamma, GW9662 (1 mu mol/L). In conclusion, our findings show that exposing cardiomyocytes to high glucose results in cardiomyocyte functional and structural abnormalities, and these abnormalities are prevented by pretreatment with CIA and mediated, in part, by peroxisome proliferator-activated receptor gamma activation. Crown Copyright (C) 2016 Published by Elsevier Inc. All rights reserved.
C1 [Aloud, Basma Milad; Raj, Pema; Netticadan, Thomas] Univ Manitoba, Dept Physiol & Pathophysiol, Winnipeg, MB R3E 0J9, Canada.
   [Aloud, Basma Milad; Raj, Pema; O'Hara, Kimberley; Shao, Zongjun; Yu, Liping; Anderson, Hope D.; Netticadan, Thomas] Canadian Ctr Agri Food Res Hlth & Med, Winnipeg, MB R2H 2A6, Canada.
   [Anderson, Hope D.] Univ Manitoba, Coll Pharm, Winnipeg, MB R3E 0T5, Canada.
C3 University of Manitoba; University of Manitoba
RP Anderson, HD; Netticadan, T (corresponding author), Canadian Ctr Agri Food Res Hlth & Med, Winnipeg, MB R2H 2A6, Canada.; Anderson, HD (corresponding author), Univ Manitoba, Coll Pharm, Winnipeg, MB R3E 0T5, Canada.
EM handerson@sbrc.ca; tnetticadan@sbrc.ca
RI BAJWA, PROF.(DR.) DES RAJ/AAA-1007-2020
OI BAJWA, PROF.(DR.) DES RAJ/0000-0002-4050-4778; Anderson,
   Hope/0000-0001-6570-6678
FU Manitoba Health Research Council; St Boniface Hospital and Research
   Foundation; Agriculture and Agri-Food Canada; Libyan-North American
   Scholarship Program
FX This study was supported by grants from Manitoba Health Research Council
   and St Boniface Hospital and Research Foundation to H.D.A., and
   Agriculture and Agri-Food Canada to T.N. B.A. was supported by a
   scholarship from the Libyan-North American Scholarship Program.
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NR 52
TC 9
Z9 9
U1 0
U2 8
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0271-5317
J9 NUTR RES
JI Nutr. Res.
PD FEB
PY 2016
VL 36
IS 2
BP 134
EP 142
DI 10.1016/j.nutres.2015.11.012
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA DD2UD
UT WOS:000369776800004
PM 26826429
DA 2025-06-11
ER

PT J
AU Joris, PJ
   Zeegers, MP
   Mensink, RP
AF Joris, Peter J.
   Zeegers, Maurice P.
   Mensink, Ronald P.
TI Weight loss improves fasting flow-mediated vasodilation in adults: A
   meta-analysis of intervention studies
SO ATHEROSCLEROSIS
LA English
DT Article
DE Flow-mediated vasodilation; Endothelial function; Weight loss;
   Intervention studies; Meta-analysis
ID LOW-CARBOHYDRATE DIET; VASCULAR ENDOTHELIAL FUNCTION;
   VERY-LOW-CARBOHYDRATE; LOW-FAT DIETS; OXIDATIVE-STRESS; METABOLIC
   SYNDROME; ADIPOSE-TISSUE; OBESE SUBJECTS; MEDITERRANEAN DIET; BARIATRIC
   SURGERY
AB Background: Obesity is associated with vascular endothelial dysfunction. Effects of weight loss on endothelial function are however not clear. Therefore, we performed a meta-analysis to quantify effects of weight loss on flow-mediated vasodilation (FMD) of the brachial artery, a measurement of endothelial function.
   Methods: Studies with experimental (RCTs) and quasi-experimental designs published before June 2014 were identified by a systematic search. Changes in FMD were defined as the difference between measurements before and after the study. For RCTs, changes were corrected for those in the no-weight loss control group. Summary estimates of weighted mean differences (WMDs) in FMD and 95% confidence intervals (CIs) were calculated using random-effect meta-analyses. The impact of subject characteristics, type of weight-loss treatment, and dietary composition on changes in FMD was also investigated.
   Results: Four RCTs involving 265 subjects were included. Weight loss increased FMD vs. control by 3.29% (95% CI: 0.98-5.59%; P = 0.005; mean weight loss: 8.6 kg). A total of 1517 subjects participated in 33 studies with 49 relevant study arms. It was estimated that each 10 kg decrease in body weight increased fasting FMD by 1.11% (95% CI: 0.47-1.76%; P = 0.001). Effects were more pronounced when participants had coexisting obesity-related morbidities. Also, effects may be larger when subjects received low-fat diets or weight-reduction regimens including exercise therapy or weight-loss medication.
   Conclusion: Weight loss significantly improves fasting FMD in adults, which is a risk marker for cardiovascular disease. Effects may depend on subject characteristics, type of weight-loss treatment, and dietary composition. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
C1 [Joris, Peter J.; Mensink, Ronald P.] Maastricht Univ, Med Ctr, NUTRIM Sch Nutr Toxicol & Metab, Dept Human Biol, NL-6200 MD Maastricht, Netherlands.
   [Joris, Peter J.; Mensink, Ronald P.] TIFN, Wageningen, Netherlands.
   [Zeegers, Maurice P.] Maastricht Univ, Med Ctr, NUTRIM Sch Nutr Toxicol & Metab, Dept Complex Genet, NL-6200 MD Maastricht, Netherlands.
C3 Maastricht University; Maastricht University Medical Centre (MUMC); Top
   Institute Food & Nutrition; Maastricht University; Maastricht University
   Medical Centre (MUMC)
RP Joris, PJ (corresponding author), Maastricht Univ, Med Ctr, NUTRIM Sch Nutr Toxicol & Metab, Dept Human Biol, POB 616, NL-6200 MD Maastricht, Netherlands.
EM p.joris@maastrichtuniversity.nl; m.zeegers@maastrichtuniversity.nl;
   r.mensink@maastichtuniversity.nl
RI Joris, Peter/AAT-8570-2021
OI Joris, Peter J/0000-0001-6852-5776
FU TI Food and Nutrition [CH001]
FX The present study is funded by research grant CH001 from the TI Food and
   Nutrition, a public-private partnership on precompetitive research in
   food and nutrition. The public partners are responsible for the study
   design, data collection and analysis, decision to publish, and
   preparation of the manuscript. The private partners have contributed to
   the project through regular discussion.
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NR 76
TC 52
Z9 55
U1 0
U2 10
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0021-9150
EI 1879-1484
J9 ATHEROSCLEROSIS
JI Atherosclerosis
PD MAR
PY 2015
VL 239
IS 1
BP 21
EP 30
DI 10.1016/j.atherosclerosis.2014.12.056
PG 10
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA CB6RH
UT WOS:000349753800004
PM 25568949
DA 2025-06-11
ER

PT J
AU Yan, SL
   Yang, HT
   Lee, YJ
   Lin, CC
   Chang, MH
   Yin, MC
AF Yan, Sheng-Lei
   Yang, Hui-Ting
   Lee, Yi-Ju
   Lin, Chun-Che
   Chang, Ming-Hui
   Yin, Mei-Chin
TI Asiatic Acid Ameliorates Hepatic Lipid Accumulation and Insulin
   Resistance in Mice Consuming a High-Fat Diet
SO JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
LA English
DT Article
DE asiatic acid; high-fat diet; hepatic steatosis; insulin resistance
ID STEAROYL-COA DESATURASE; OXIDATIVE STRESS; METABOLIC SYNDROME; OBESE
   MICE; EXPRESSION; LIVER; SUPPRESSION; STEATOSIS; RATS; STEATOHEPATITIS
AB Effects of asiatic acid (AA) at 10 or 20 mg/kg/day upon hepatic steatosis in mice consuming a high-fat diet (HFD) were examined. AA intake decreased body weight, water intake, feed intake, epididymal fat, and plasma and hepatic triglyceride levels in HFD-treated mice (P < 0.05). HFD enhanced 2.85-fold acetyl coenzyme A carboxylase (ACC1), 3.34-fold fatty acid synthase (FAS), 3.71-fold stearoyl CoA desaturase (SCD)-1, 3.62-fold 3-hydroxy-3-methylglutaryl coenzyme A reductase, 2.91-fold sterol regulatory element-binding protein (SREBP)-1c, and 2.75-fold SREBP-2 expression in liver (P < 0.05). Compared with HFD groups, AA intake at two doses reduced 18.9-45.7% ACC1, 25.1-49.8% FAS, 24.7-57.1% SCD-1, and 21.8-53.3% SREBP-1c protein expression (P < 0.05). Histological results indicated AA intake at two doses reduced hepatic lipid accumulation and inflammatory infiltrate. HFD increased hepatic production of reactive oxygen species, interleukin (IL)-1 beta, IL-6, and tumor necrosis factor-a, as well as decreased hepatic glutathione content and glutathione peroxidase and catalase activities (P < 0.05). AA intake at two doses reversed these alterations (P < 0.05). AA intake suppressed 32.4-58.8% nuclear factor kappa (NF-kappa)B p65 and 24.2-56.7% p-p38 expression (P < 0.05) and at high dose down-regulated 29.1% NF-kappa B p50 and 40.7% p-JNK expression in livers from HFD-treated mice. AA intake at two doses lowered plasma insulin secretion and HOMR-IR (P < 0.05). These results suggest that AA is a potent hepatic protective agent against HFD-induced hepatic injury.
C1 [Yan, Sheng-Lei] Chang Bing Show Chwan Mem Hosp, Dept Internal Med, Div Gastroenterol, Lugang Township, Changhua County, Taiwan.
   [Yang, Hui-Ting; Yin, Mei-Chin] China Med Univ, Dept Nutr, Taichung, Taiwan.
   [Lee, Yi-Ju] Chung Shan Med Univ Hosp, Dept Pathol, Taichung, Taiwan.
   [Lin, Chun-Che; Chang, Ming-Hui] Chung Shan Med Univ Hosp, Dept Internal Med, Div Gastroenterol & Hepatol, Taichung, Taiwan.
   [Yin, Mei-Chin] Asia Univ, Dept Hlth & Nutr Biotechnol, Taichung, Taiwan.
C3 Chang Bing Show Chwan Memorial Hospital; China Medical University
   Taiwan; Chung Shan Medical University; Chung Shan Medical University
   Hospital; Chung Shan Medical University; Chung Shan Medical University
   Hospital; Asia University Taiwan
RP Yin, MC (corresponding author), China Med Univ, Dept Nutr, 91 Hsueh Shih Rd, Taichung, Taiwan.
EM mcyin@mail.cmu.edu.tw
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NR 31
TC 36
Z9 41
U1 1
U2 27
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0021-8561
EI 1520-5118
J9 J AGR FOOD CHEM
JI J. Agric. Food Chem.
PD MAY 21
PY 2014
VL 62
IS 20
BP 4625
EP 4631
DI 10.1021/jf501165z
PG 7
WC Agriculture, Multidisciplinary; Chemistry, Applied; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture; Chemistry; Food Science & Technology
GA AH8VV
UT WOS:000336417200018
PM 24779966
DA 2025-06-11
ER

PT J
AU Lam, VKL
   Ma, RCW
   Lee, HM
   Hu, C
   Park, KS
   Furuta, H
   Wang, Y
   Tam, CHT
   Sim, XL
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   Liu, JJ
   Wong, TY
   Tai, ES
   Morris, AP
   Tang, NLS
   Woo, J
   Leung, PC
   Kong, APS
   Ozaki, R
   Jia, WP
   Lee, HK
   Nanjo, K
   Xu, G
   Ng, MCY
   So, WY
   Chan, JCN
AF Lam, Vincent Kwok Lim
   Ma, Ronald Ching Wan
   Lee, Heung Man
   Hu, Cheng
   Park, Kyong Soo
   Furuta, Hiroto
   Wang, Ying
   Tam, Claudia Ha Ting
   Sim, Xueling
   Ng, Daniel Peng-Keat
   Liu, Jianjun
   Wong, Tien-Yin
   Tai, E. Shyong
   Morris, Andrew P.
   Tang, Nelson Leung Sang
   Woo, Jean
   Leung, Ping Chung
   Kong, Alice Pik Shan
   Ozaki, Risa
   Jia, Wei Ping
   Lee, Hong Kyu
   Nanjo, Kishio
   Xu, Gang
   Ng, Maggie Chor Yin
   So, Wing-Yee
   Chan, Juliana Chung Ngor
CA DIAGRAM Consortium
TI Genetic Associations of Type 2 Diabetes with Islet Amyloid Polypeptide
   Processing and Degrading Pathways in Asian Populations
SO PLOS ONE
LA English
DT Article
ID HUMAN PANCREATIC-ISLETS; ENDOPLASMIC-RETICULUM STRESS; TRANSCRIPTION
   FACTOR; SUSCEPTIBILITY LOCI; METABOLIC SYNDROME; INSULIN; MELLITUS;
   OBESITY; HHEX; RISK
AB Type 2 diabetes (T2D) is a complex disease characterized by beta cell dysfunctions. Islet amyloid polypeptide (IAPP) is highly conserved and co-secreted with insulin with over 40% of autopsy cases of T2D showing islet amyloid formation due to IAPP aggregation. Dysregulation in IAPP processing, stabilization and degradation can cause excessive oligomerization with beta cell toxicity. Previous studies examining genetic associations of pathways implicated in IAPP metabolism have yielded conflicting results due to small sample size, insufficient interrogation of gene structure and gene-gene interactions. In this multi-staged study, we screened 89 tag single nucleotide polymorphisms (SNPs) in 6 candidate genes implicated in IAPP metabolism and tested for independent and joint associations with T2D and beta cell dysfunctions. Positive signals in the stage-1 were confirmed by de novo and in silico analysis in a multi-centre unrelated case-control cohort. We examined the association of significant SNPs with quantitative traits in a subset of controls and performed bioinformatics and relevant functional analyses. Amongst the tag SNPs, rs1583645 in carboxypeptidase E (CPE) and rs6583813 in insulin degrading enzyme (IDE) were associated with 1.09 to 1.28 fold increased risk of T2D (P-Meta = 9.4x10(-3) and 0.02 respectively) in a meta-analysis of East Asians. Using genetic risk scores (GRS) with each risk variant scoring 1, subjects with GRS >= 3 (8.2% of the cohort) had 56% higher risk of T2D than those with GRS = 0 (P = 0.01). In a subcohort of control subjects, plasma IAPP increased and beta cell function index declined with GRS (P = 0.008 and 0.03 respectively). Bioinformatics and functional analyses of CPE rs1583645 predicted regulatory elements for chromatin modification and transcription factors, suggesting differential DNA-protein interactions and gene expression. Taken together, these results support the importance of dysregulation of IAPP metabolism in T2D in East Asians.
C1 [Lam, Vincent Kwok Lim; Ma, Ronald Ching Wan; Lee, Heung Man; Wang, Ying; Tam, Claudia Ha Ting; Woo, Jean; Kong, Alice Pik Shan; Ozaki, Risa; Xu, Gang; Ng, Maggie Chor Yin; So, Wing-Yee; Chan, Juliana Chung Ngor] Chinese Univ Hong Kong, Prince Wales Hosp, Dept Med & Therapeut, Shatin, Hong Kong, Peoples R China.
   [Tang, Nelson Leung Sang] Chinese Univ Hong Kong, Prince Wales Hosp, Dept Chem Pathol, Shatin, Hong Kong, Peoples R China.
   [Leung, Ping Chung] Chinese Univ Hong Kong, Prince Wales Hosp, Dept Orthopaed & Traumatol, Shatin, Hong Kong, Peoples R China.
   [Hu, Cheng; Jia, Wei Ping] Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Shanghai Clin Ctr Diabet,Shanghai Key Clin Ctr Me, Dept Endocrinol & Metab,Shanghai Diabet Inst, Shanghai 200030, Peoples R China.
   [Park, Kyong Soo; Lee, Hong Kyu] Seoul Natl Univ, Coll Med, Dept Internal Med, Dept Mol Med & Biopharmaceut Sci,Grad Sch Converg, Seoul 151, South Korea.
   [Furuta, Hiroto; Nanjo, Kishio] Wakayama Med Univ, Dept Med 1, Wakayama, Japan.
   [Ma, Ronald Ching Wan; Xu, Gang; Chan, Juliana Chung Ngor] Chinese Univ Hong Kong, Hong Kong Inst Diabet & Obes, Hong Kong, Hong Kong, Peoples R China.
   [Ma, Ronald Ching Wan; Xu, Gang; Chan, Juliana Chung Ngor] Chinese Univ Hong Kong, Prince Wales Hosp, Li Ka Shing Inst Hlth, Shatin, Hong Kong, Peoples R China.
   [Sim, Xueling] Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Ctr Mol Epidemiol, Singapore 117548, Singapore.
   [Ng, Daniel Peng-Keat; Liu, Jianjun; Tai, E. Shyong] Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore 117548, Singapore.
   [Liu, Jianjun] Agcy Sci Technol & Res, Genome Inst Singapore, Singapore, Singapore.
   [Wong, Tien-Yin] Singapore Natl Eye Ctr, Singapore Eye Res Inst, Singapore, Singapore.
   [Wong, Tien-Yin] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Ophthalmol, Singapore 117595, Singapore.
   [Tai, E. Shyong] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Med, Singapore 117595, Singapore.
   [Tai, E. Shyong] Duke Natl Univ Singapore, Grad Sch Med, Singapore, Singapore.
   [Morris, Andrew P.] Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.
C3 Chinese University of Hong Kong; Prince of Wales Hospital; Chinese
   University of Hong Kong; Prince of Wales Hospital; Chinese University of
   Hong Kong; Prince of Wales Hospital; Shanghai Jiao Tong University;
   Seoul National University (SNU); Wakayama Medical University; Chinese
   University of Hong Kong; Chinese University of Hong Kong; Prince of
   Wales Hospital; National University of Singapore; National University of
   Singapore; Agency for Science Technology & Research (A*STAR); A*STAR -
   Genome Institute of Singapore (GIS); Singapore National Eye Center;
   National University of Singapore; National University of Singapore;
   National University of Singapore; National University of Singapore;
   University of Oxford; Wellcome Centre for Human Genetics
RP Chan, JCN (corresponding author), Chinese Univ Hong Kong, Prince Wales Hosp, Dept Med & Therapeut, Shatin, Hong Kong, Peoples R China.
EM jchan@cuhk.edu.hk
RI Wong, Tien/AAC-9724-2020; Kong, Alice/P-3703-2015; Sim,
   Xueling/AAZ-6652-2020; Liu, Jianjun/AAK-4989-2020; Ng,
   Maggie/LPP-8829-2024; Tang, Nelson/P-5018-2017; Jia,
   Weiping/B-7483-2012; Hu, Cheng/C-3346-2008; Park, Kyong Soo/C-2265-2008;
   Ma, Ronald/C-2788-2009; Woo, Jean/K-2625-2014; Chan, Juliana/B-7918-2016
OI Jia, Weiping/0000-0002-6244-2168; Hu, Cheng/0000-0003-4314-2386; Tai, E
   Shyong/0000-0003-2929-8966; Wijmenga, Cisca/0000-0002-5635-1614; Liu,
   Jianjun/0000-0002-3255-3019; Tang, Nelson/0000-0002-3607-5819; Park,
   Kyong Soo/0000-0003-3597-342X; Ma, Ronald/0000-0002-1227-803X; Woo,
   Jean/0000-0001-7593-3081; Sim, Xueling/0000-0002-1233-7642; Chan,
   Juliana/0000-0003-1325-1194; Kong, Alice/0000-0001-8927-6764
FU Chinese University of Hong Kong (CUHK) [2041565]; Research Grants
   Council (RGC) Central Allocation Scheme [CUHK 1/04C]; earmarked grant
   [CUHK4462/06M]; National Institutes of Health (NIH) [6903078]; Hong Kong
   Foundation for Research and Development in Diabetes; Liao Wun Yuk
   Diabetes Research Memorial Fund; National Natural Scientific Foundation
   of China [30630061]; Shanghai Key Laboratory of Diabetes Mellitus
   [08DZ2230200]; National Project for Personalized Genomic Medicine,
   Ministry for Health & Welfare, Republic of Korea [A111218-GM09];
   Ministry of Education, Culture, Sports, Science and Technology of Japan
   [17019047]; Biomedical Research Council of Singapore
   [BMRC05/1/36/19/413, 03/1/27/18/216]; National Medical Research Council
   of Singapore [NMRC/1174/2008]; National Medical Research Council
   [NMRC0796/2003, NMRC/STaR/0003/2008]; Biomedical Research Council
   [BMRC09/1/35/19/616]; National Medical Research Council; Grants-in-Aid
   for Scientific Research [17019047, 23591319] Funding Source: KAKEN
FX This work was supported by the Chinese University of Hong Kong (CUHK) -
   Direct Grant (2041565), the Research Grants Council (RGC) Central
   Allocation Scheme (CUHK 1/04C), earmarked grant (CUHK4462/06M) and
   National Institutes of Health (NIH) grant (Project code: 6903078) as
   well as the Hong Kong Foundation for Research and Development in
   Diabetes and Liao Wun Yuk Diabetes Research Memorial Fund established
   under the Chinese University of Hong Kong. The research in Shanghai,
   China was supported by grants from the National Natural Scientific
   Foundation of China (30630061) and Shanghai Key Laboratory of Diabetes
   Mellitus (08DZ2230200). This study was supported by a grant of the
   National Project for Personalized Genomic Medicine, Ministry for Health
   & Welfare, Republic of Korea (A111218-GM09). The work in Japan was
   supported by Grant-in-Aid for Scientific Research on Priority Areas
   "Applied Genomics" (17019047) from the Ministry of Education, Culture,
   Sports, Science and Technology of Japan. The Singapore Prospective Study
   Program (SP2) was funded through grants from the Biomedical Research
   Council of Singapore (BMRC05/1/36/19/413 and 03/1/27/18/216) and the
   National Medical Research Council of Singapore (NMRC/1174/2008). The
   Singapore Malay Eye Study (SiMES) was funded by the National Medical
   Research Council (NMRC0796/2003 and NMRC/STaR/0003/2008) and Biomedical
   Research Council (BMRC09/1/35/19/616). EST also received additional
   support from the National Medical Research Council through a clinician
   scientist award. The Singapore BioBank and the Genome Institute of
   Singapore, Agency for Science, Technology and Research, Singapore
   provided services for tissue archival and genotyping, respectively. The
   funders had no role in study design, data collection and analysis,
   decision to publish, or preparation of the manuscript.
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NR 55
TC 8
Z9 9
U1 1
U2 21
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JUN 11
PY 2013
VL 8
IS 6
AR e62378
DI 10.1371/journal.pone.0062378
PG 12
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 169CU
UT WOS:000320755400002
PM 23776430
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Nakamura, K
   Sakurai, M
   Miura, K
   Morikawa, Y
   Nagasawa, S
   Ishizaki, M
   Kido, T
   Naruse, Y
   Suwazono, Y
   Nakagawa, H
AF Nakamura, K.
   Sakurai, M.
   Miura, K.
   Morikawa, Y.
   Nagasawa, S.
   Ishizaki, M.
   Kido, T.
   Naruse, Y.
   Suwazono, Y.
   Nakagawa, H.
TI Serum Gamma-Glutamyltransferase and the Risk of Hyperuricemia: A 6-Year
   Prospective Study in Japanese Men
SO HORMONE AND METABOLIC RESEARCH
LA English
DT Article
DE gamma-glutamyltransferase; aspartate aminotransferase; alanine
   aminotransferase; hyperuricemia; epidemiology
ID 3RD NATIONAL-HEALTH; URIC-ACID LEVEL; INSULIN SENSITIVITY; METABOLIC
   SYNDROME; FOLLOW-UP; OXIDATIVE STRESS; LIVER-DISEASE; UNITED-STATES;
   ASSOCIATION; RESISTANCE
AB We conducted a longitudinal study to investigate whether increased serum gamma-glutamyltransferase independently predicts subsequent development of hyperuricemia. The study participants included 3 310 Japanese men without hyperuricemia, aged 20-54 years. The participants had annual heath examinations for 6 years to assess incident hyperuricemia (defined as serum uric acid >416.4 mu mol/l and/or taking medication for hyperuricemia). The risk of incident hyperuricemia was compared in participants grouped according to their baseline serum gamma-glutamyltransferase level. During follow-up, there were 529 incident cases of hyperuricemia. A positive, dose-response relationship was observed between serum gamma-glutamyltransferase and the risk of incident hyperuricemia. The hazard ratios (95 % confidence intervals) for hyperuricemia, compared with a serum gamma-glutamyltransferase level <= 19 U/l, were 1.32 (1.05-1.67) for 20-39 U/l, 1.28 (0.90-1.83) for 40-59 U/l, 1.56 (0.98-2.47) for 60-79 U/l, and 1.57 (1.02-2.41) for >= 80 U/l after adjustment for baseline serum uric acid, creatinine, total cholesterol, and glycated hemoglobin levels, ln(serum alanine aminotransferase), age, systolic blood pressure, medications for hypertension, hypercholesterolemia, and diabetes, body mass index, and smoking and exercise habits. A similar positive relationship was observed regardless of the presence or absence of alcohol drinking, obesity, metabolic disorders (any combination of hypertension, hypercholesterolemia and/or diabetes), or clinically high serum aminotransferases, without evidence of a significant interaction between increased serum gamma-glutamyltransferase and risk factors for incident hyperuricemia. These findings indicate that increased serum gamma-glutamyltransferase is an independent predictor of subsequent development of hyperuricemia.
C1 [Nakamura, K.; Sakurai, M.; Morikawa, Y.; Nagasawa, S.; Nakagawa, H.] Kanazawa Med Univ, Dept Epidemiol & Publ Hlth, Uchinada, Ishikawa 9200293, Japan.
   [Miura, K.] Shiga Univ Med Sci, Dept Hlth Sci, Otsu, Shiga 52021, Japan.
   [Ishizaki, M.] Kanazawa Med Univ, Dept Social & Environm Med, Uchinada, Ishikawa 9200293, Japan.
   [Kido, T.] Kanazawa Univ, Coll Med Pharmaceut & Hlth Sci, Sch Hlth Sci, Kanazawa, Ishikawa, Japan.
   [Naruse, Y.] Toyama Univ, Sch Nursing, Dept Human Sci & Fundamental Nursing, Toyama 930, Japan.
   [Suwazono, Y.] Chiba Univ, Grad Sch Med, Dept Occupat & Environm Med, Chiba, Japan.
C3 Kanazawa Medical University; Shiga University of Medical Science;
   Kanazawa Medical University; Kanazawa University; University of Toyama;
   Chiba University
RP Nakamura, K (corresponding author), Kanazawa Med Univ, Dept Epidemiol & Publ Hlth, 1-1 Daigaku, Uchinada, Ishikawa 9200293, Japan.
EM knaka@kanazawa-med.ac.jp
RI Sakurai, Masaru/AAC-6551-2021
OI Miura, Katsuyuki/0000-0002-2646-9582
FU Ministry of Health, Labour and Welfare, Health and Labour Sciences,
   Japan [H17-Kenkou-007, H18-Junkankitou [Seishuu]-Ippan-012,
   H19-Junkankitou [Seishuu]-Ippan-021, H20-Junkankitou
   [Seishuu]-Ippan-013, H22-Junkankitou [Seishuu]-Ippan-005,
   H23-Junkankitou [Seishuu]-Ippan-005]; Japan Arteriosclerosis Prevention
   Fund
FX The present study was supported by a Grant-in-Aid from the Ministry of
   Health, Labour and Welfare, Health and Labour Sciences Research Grants,
   Japan (H17-Kenkou-007, H18-Junkankitou [Seishuu]-Ippan-012,
   H19-Junkankitou [Seishuu]-Ippan-021, H20-Junkankitou
   [Seishuu]-Ippan-013, H22-Junkankitou [Seishuu]-Ippan-005,
   H23-Junkankitou [Seishuu]-Ippan-005) and by the Japan Arteriosclerosis
   Prevention Fund.
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NR 46
TC 7
Z9 10
U1 0
U2 11
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0018-5043
EI 1439-4286
J9 HORM METAB RES
JI Horm. Metab. Res.
PD DEC
PY 2012
VL 44
IS 13
BP 966
EP 974
DI 10.1055/s-0032-1321788
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 056OZ
UT WOS:000312501800007
PM 22821008
DA 2025-06-11
ER

PT J
AU Zaman, MQ
   Leray, V
   Le Bloc'h, J
   Thorin, C
   Ouguerram, K
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AF Zaman, Muhammad-Quaid
   Leray, Veronique
   Le Bloc'h, Jerome
   Thorin, Chantal
   Ouguerram, Khadija
   Nguyen, Patrick
TI Lipid profile and insulin sensitivity in rats fed with high-fat or
   high-fructose diets
SO BRITISH JOURNAL OF NUTRITION
LA English
DT Article
DE insulin resistance; obesity; dyslipidemia; high-fat diet; high-fructose
   diet; rat
ID METABOLIC SYNDROME; RESISTANCE; LIVER; CARBOHYDRATE; PHOSPHORYLATION;
   ADAPTATION; BALANCE; OBESITY; STRESS
AB The occurrence and severity of obesity-and insulin resistance-related disorders vary according to the diet. The aim of the present longitudinal study was to examine the effects of a high-fat or a high-fructose diet on body weight (BW), body fat mass, insulin sensitivity (IS) and lipid profiles in a rat model of dietary-induced obesity and low IS. A total of eighteen, 12-week-old male Wistar rats were divided into three groups, and were fed with a control, a high-fat (65% lipid energy) or a high-fructose diet (65% fructose energy) for 10 weeks. BW, body fat mass ((H2O)-H-2 dilution method), IS (euglycaemic-hyperinsulinaemic clamp technique), plasma glucose, insulin, NEFA, TAG and total cholesterol were assessed before and at the end of 10-week period. Cholesterol was measured in plasma lipoproteins separated from pooled samples of each group and each time period by using fast-protein liquid chromatography. All rats had similar BW at the end of the 10-week period. Body fat mass was higher in the high-fat group compared to the control group. There was no change in basal glycaemia and insulinaemia. The IS was lower in the high-fat group and was unchanged in the high-fructose group, compared to the control group. Plasma TAG concentration and cholesterol distribution in lipoproteins did not change over time in any group. Plasma NEFA concentration decreased, whereas plasma TAG concentration increased over time, regardless of the diet in both cases. The 10-week high-fat diet led to obesity and low IS, whereas rats fed with the high-fructose diet exhibited no change in IS and lipidaemia. The high-fat diet had more deleterious response than high-fructose diet to induce obesity and low IS in rats.
C1 [Zaman, Muhammad-Quaid; Leray, Veronique; Le Bloc'h, Jerome; Nguyen, Patrick] LUNAM Univ, Natl Coll Vet Med Food Sci & Engn, Endocrinol & Nutr Unit, Oniris, F-44307 Nantes 3, France.
   [Zaman, Muhammad-Quaid; Leray, Veronique; Le Bloc'h, Jerome; Ouguerram, Khadija; Nguyen, Patrick] CHU Nantes, Human Nutr Res Ctr Nantes, CRNH, F-44093 Nantes, France.
   [Le Bloc'h, Jerome; Ouguerram, Khadija] Inst Thorax, INSERM, UMR 915, F-44000 Nantes, France.
   [Thorin, Chantal] LUNAM Univ, Natl Coll Vet Med Food Sci & Engn, Stat Unit, Oniris, F-44307 Nantes 3, France.
C3 Ecole Nationale Veterinaire, Agroalimentaire et de l'Alimentation
   Nantes-Atlantique; Nantes Universite; CHU de Nantes; Institut National
   de la Sante et de la Recherche Medicale (Inserm); Nantes Universite; CHU
   de Nantes; Ecole Nationale Veterinaire, Agroalimentaire et de
   l'Alimentation Nantes-Atlantique
RP Nguyen, P (corresponding author), LUNAM Univ, Natl Coll Vet Med Food Sci & Engn, Endocrinol & Nutr Unit, Oniris, POB 40706, F-44307 Nantes 3, France.
EM patrick.nguyen@oniris-nantes.fr
FU Higher Education Commission, Pakistan
FX The financial support in the form of doctoral fellowship to M.-Q. Z.
   from the Higher Education Commission, Pakistan, is greatly acknowledged.
   The authors are grateful to Philippe Bleis and Samuel Ninet for their
   technical assistance and for taking care of the animals. The present
   study was designed by P. N., V. L., K. O. and M.-Q. Z. and supervised by
   P. N. and V. L; M.-Q. Z. performed the experiments; C. T. and M.-Q. Z.
   conducted the statistical analysis; M.-Q. Z. and J. L. B. wrote the
   manuscript; and P. N., V. L., K. O. and J. L. B. critically reviewed the
   manuscript. The authors declare no conflicts of interest.
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NR 26
TC 25
Z9 28
U1 1
U2 14
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1145
EI 1475-2662
J9 BRIT J NUTR
JI Br. J. Nutr.
PD OCT
PY 2011
VL 106
SU 1
BP S206
EP S210
DI 10.1017/S0007114511004454
PG 5
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 842OS
UT WOS:000296609400045
PM 22005430
OA Bronze
DA 2025-06-11
ER

PT J
AU Jung, CH
   Yu, JH
   Bae, SJ
   Koh, EH
   Kim, MS
   Park, JY
   Kim, HK
   Lee, WJ
AF Jung, Chang Hee
   Yu, Ji Hee
   Bae, Sung Jin
   Koh, Eun Hee
   Kim, Min-Seon
   Park, Joong-Yeol
   Kim, Hong-Kyu
   Lee, Woo Je
TI Serum gamma-glutamyltransferase is associated with arterial stiffness in
   healthy individuals
SO CLINICAL ENDOCRINOLOGY
LA English
DT Article
ID PULSE-WAVE VELOCITY; CARDIOVASCULAR-DISEASE; AORTIC STIFFNESS; ALANINE
   AMINOTRANSFERASE; TRANSPEPTIDASE ACTIVITY; INDEPENDENT PREDICTOR;
   HYPERTENSIVE PATIENTS; METABOLIC SYNDROME; OXIDATIVE STRESS; H2O2
   PRODUCTION
AB Objective Gamma-glutamyltransferase (GGT) has been reported to be useful in predicting cardiovascular disease. Arterial stiffness measured by brachial-ankle pulse wave velocity (baPWV) is not only a marker of vascular damage but a significant predictor of cardiovascular events. Gender difference has been reported in the association between GGT and baPWV. We assessed, therefore, the association between GGT and baPWV in a large population and determined whether there was gender difference.
   Design This cross-sectional study was conducted at the Asan Medical Centre, Seoul, Republic of Korea.
   Subjects and measurements Serum GGT, baPWV and conventional risk factors were measured in 10.988 apparently healthy subjects (7248 men, 3740 women) who participated in a routine health screening examination.
   Results In both men and women, we observed positive linearity between GGT quartiles and body mass index, waist circumference, systolic blood pressure, diastolic blood pressure, fasting plasma glucose, total cholesterol, LDL cholesterol, triglycerides, uric acid, high-sensitive C-reactive protein (hsCRP) and homeostatic model assessment of insulin resistance (HOMA-IR) score (P for trends < 0.001). The proportion of individuals with diabetes, hypertension increased as the GGT quartile increased (P for trends < 0.001). Age-adjusted mean baPWV increased gradually in both males and females according to GGT quartiles (P for trends < 0.001 in both genders). The odds for higher baPWV (i.e. >75th percentile in each sex) were significantly higher in the highest compared with the lowest GGT quartiles, after adjustment for confounding variables, in both men [odds ratio (OR) = 1.63, 95% CI = 1.21-2.20] and women (OR = 1.56, 95% CI = 1.08-2.27).
   Conclusions These results suggest that GGT is independently associated with the increased level of arterial stiffness both in men and in women and the association between them appears to be stronger in men compared to women.
C1 [Jung, Chang Hee; Yu, Ji Hee; Koh, Eun Hee; Kim, Min-Seon; Park, Joong-Yeol; Lee, Woo Je] Univ Ulsan, Coll Med, Dept Internal Med, Seoul 138736, South Korea.
   [Bae, Sung Jin; Kim, Hong-Kyu] Univ Ulsan, Coll Med, Dept Hlth Screening & Promot Ctr, Asan Med Ctr, Seoul 138736, South Korea.
C3 University of Ulsan; University of Ulsan; Asan Medical Center
RP Lee, WJ (corresponding author), Univ Ulsan, Coll Med, Dept Internal Med, 388-1 Poongnap Dong, Seoul 138736, South Korea.
EM hkkim0801@amc.seoul.kr; lwjatlas@naver.com
RI Park, Kyoung Un/J-5473-2012; Park, Jun/HPH-3570-2023; Jung,
   Chang/AAU-7897-2020; Kim, Seunghyun/AAA-3402-2022
OI Yu, Ji Hee/0000-0003-1907-2859; Jung, Chang Hee/0000-0003-4043-2396
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NR 35
TC 33
Z9 35
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0300-0664
EI 1365-2265
J9 CLIN ENDOCRINOL
JI Clin. Endocrinol.
PD SEP
PY 2011
VL 75
IS 3
BP 328
EP 334
DI 10.1111/j.1365-2265.2011.04060.x
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 811ZC
UT WOS:000294256500010
PM 21521327
OA Bronze
DA 2025-06-11
ER

PT J
AU Lauressergues, E
   Martin, F
   Helleboid, A
   Bouchaert, E
   Cussac, D
   Bordet, R
   Hum, D
   Luc, G
   Majd, Z
   Staels, B
   Duriez, P
AF Lauressergues, Emilie
   Martin, Francoise
   Helleboid, Audrey
   Bouchaert, Emmanuel
   Cussac, Didier
   Bordet, Regis
   Hum, Dean
   Luc, Gerald
   Majd, Zouher
   Staels, Bart
   Duriez, Patrick
TI Overweight induced by chronic risperidone exposure is correlated with
   overexpression of the SREBP-1c and FAS genes in mouse liver
SO NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
LA English
DT Article
DE Atypical antipsychotics; Risperidone; Weight; Liver; SREBP-1c; FAS
ID ATYPICAL ANTIPSYCHOTIC-DRUGS; ACTIVATED RECEPTOR-ALPHA; ELEMENT-BINDING
   PROTEIN; RETICULUM STRESS CAUSES; INDUCED WEIGHT-GAIN; HEPATIC
   STEATOSIS; TRANSGENIC MICE; FATTY-ACID; ANTIDEPRESSANT-DRUGS; METABOLIC
   SYNDROME
AB Weight gain and metabolic disturbances, such as dyslipidemia and hyperglycaemia, are common side effects of most antipsychotic drugs, including risperidone. The aim of this study was to investigate the effects of chronic treatment with risperidone on body weight, fat accumulation, liver weight, and hepatic expression of key genes involved in lipid metabolism in female mice. We also addressed the mechanism of risperidone induction of metabolic side effects by exploring its effect on lipid and cholesterol metabolism in primary cultures of rat hepatocytes. Eleven weeks of treatment with long-acting risperidone (12.5 mpk/week) resulted in a significant weight gain associated with an increase of liver and adipose tissue weight. These effects were positively correlated with hepatic mRNA induction of two key genes involved in lipogenesis: sterol regulatory element binding protein-1c (SREBP-1c) and fatty acid synthase (FAS). Furthermore, in line with these in vivo results, risperidone elicited significant inductions of SREBP-1 maturation and FAS mRNA expression in primary cultures of rat hepatocytes associated with an increase of free fatty acid, triacylglycerol, and phospholipid synthesis as assessed by acetate incorporation. The current investigations underscore the usefulness of a mouse model to study the weight gain observed with risperidone treatment in humans. This study shows that risperidone induces similar effects in the liver (in vivo) and in hepatocyte cell cultures (in vitro) on the expression of key genes and/or proteins that control lipid metabolism. This suggests that risperidone could alter lipid metabolism in the liver and induce weight gain in a way that is partly independent of its action on the central nervous system.
C1 [Lauressergues, Emilie; Cussac, Didier] Ctr Rech Pierre Fabre, Dept Cellular & Mol Biol, F-81106 Castres, France.
   [Martin, Francoise; Helleboid, Audrey; Bordet, Regis; Luc, Gerald; Staels, Bart; Duriez, Patrick] Univ Lille Nord France, Lille, France.
   [Martin, Francoise; Helleboid, Audrey; Bouchaert, Emmanuel; Luc, Gerald; Staels, Bart] INSERM, UMR 1011, F-59045 Lille, France.
   [Martin, Francoise; Helleboid, Audrey; Luc, Gerald; Staels, Bart] Inst Pasteur, F-59019 Lille, France.
   [Martin, Francoise; Helleboid, Audrey; Luc, Gerald; Staels, Bart; Duriez, Patrick] Inst Predict Med & Therapeut Res, Fac Pharm, Lille, France.
   [Bordet, Regis; Duriez, Patrick] Inst Predict Med & Therapeut Res, Dept Med Pharmacol, Fac Med, EA 1046, Lille, France.
   [Hum, Dean; Majd, Zouher] Genfit SA, Loos, France.
C3 Universite de Lille; Universite de Lille; Institut National de la Sante
   et de la Recherche Medicale (Inserm); Pasteur Network; Universite de
   Lille; Institut Pasteur Lille; Universite de Lille; Universite de Lille
RP Lauressergues, E (corresponding author), Ctr Rech Pierre Fabre, Dept Cellular & Mol Biol, 17 Ave Jean Moulin, F-81106 Castres, France.
EM emilie.lauressergues@pierre-fabre.com
RI BOUCHAERT, Emmanuel/AFU-7112-2022; Helleboid, Audrey/NFR-8605-2025;
   Staels, Bart/N-9497-2016
OI Staels, Bart/0000-0002-3784-1503; BOUCHAERT,
   Emmanuel/0000-0003-2558-9862
FU Region Nord Pas de Calais France et le Fonds de Developpement Europeen
   Regional
FX This work was supported by Region Nord Pas de Calais France et le Fonds
   de Developpement Europeen Regional. We would thank Luc De Vries for
   critically reading the manuscript
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NR 57
TC 30
Z9 34
U1 1
U2 13
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0028-1298
EI 1432-1912
J9 N-S ARCH PHARMACOL
JI Naunyn-Schmiedebergs Arch. Pharmacol.
PD APR
PY 2011
VL 383
IS 4
BP 423
EP 436
DI 10.1007/s00210-010-0597-3
PG 14
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 737MM
UT WOS:000288572900009
PM 21336545
DA 2025-06-11
ER

PT J
AU Kabagambe, EK
   Ordovas, JM
   Tsai, MY
   Borecki, IB
   Hopkins, PN
   Glasser, SP
   Arnett, DK
AF Kabagambe, Edmond K.
   Ordovas, Jose M.
   Tsai, Michael Y.
   Borecki, Ingrid B.
   Hopkins, Paul N.
   Glasser, Stephen P.
   Arnett, Donna K.
TI Smoking, inflammatory patterns and postprandial hypertriglyceridemia
SO ATHEROSCLEROSIS
LA English
DT Article
DE Smoking; Triglycerides; Lipids; Inflammation; Insulin resistance
ID OXIDATIVE STRESS; INSULIN-RESISTANCE; METABOLIC SYNDROME; RISK;
   ATHEROSCLEROSIS; TRIGLYCERIDES; LIPOPROTEINS; DISEASE; LIPEMIA; MARKERS
AB Background: Smoking is associated with increased postprandial hypertriglyceridemia (PPT). Inflammation and insulin resistance are potential "drivers" for this phenomenon. We tested whether inflammatory patterns and/or insulin resistance explain the effect of smoking on PPT.
   Methods and results: Men and women in the NHLBI Genetics of Lipid-Lowering Drugs and Diet Network (GOLDN) Study (n = 1036, age 49 +/- 16 y) were included. Each participant was asked to suspend use of lipid-lowering drugs for 3 weeks and was given a high-fat milkshake (83% fat and 700 kcal/m(2)). Triglyceride concentrations at 0, 3.5 and 6h after the fat load were measured. Inflammatory markets were measured at baseline. Principal component analysis was used to derive inflammatory patterns from individual inflammatory markers (hsCRP, IL2 soluble receptor-alpha, IL6, TNF-alpha and MCP1). Insulin resistance (IR) was estimated using the HOMA equation. Repeated measures-ANOVA was used for analyses. Two inflammatory patterns, namely CRP-IL6 pattern and MCP1-TNF-alpha. pattern, were derived. We found significant main (smoking and time) and interaction (smoking x time) effects (P < 0.01) for triglycerides. The multivariate-adjusted triglyceride (mg/dL) concentrations (mean +/- S.E.M.) for never, past and current smokers were 127.38 +/- 1.04, 119.82 +/- 1.05 and 134.92 +/- 1.08 at 0 h; 229.42 +/- 104, 238.39 +/- 1.05 and 293.94 +/- 1.08 at 3.5 h; and 194.63 +/- 1.04, 208.38 +/- 1.05 and 248.27 +/- 1.08 at 6 h after the fat load, respectively. Smoking remained significant after adjusting for HOMA-IR and/or inflammatory patterns which showed independent associations with PPT (P < 0.05).
   Conclusions:These data confirm impaired metabolism of fat among smokers and suggest that mechanisms other than inflammation or insulin resistance may explain the observed hypertriglyceridemia among smokers. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
C1 [Kabagambe, Edmond K.; Arnett, Donna K.] Univ Alabama, Sch Publ Hlth, Dept Epidemiol, Birmingham, AL 35294 USA.
   [Ordovas, Jose M.] Tufts Univ, JM, USDA, HNRCA, Boston, MA 02111 USA.
   [Tsai, Michael Y.] Univ Minnesota, Dept Lab Med & Pathol, Minneapolis, MN 55455 USA.
   [Borecki, Ingrid B.] Washington Univ, Sch Med, Dept Genet, Div Stat Genom, St Louis, MO 63108 USA.
   [Hopkins, Paul N.] Univ Utah, Dept Internal Med, Salt Lake City, UT 84108 USA.
   [Glasser, Stephen P.] Univ Alabama, Dept Med, Div Prevent Med, Birmingham, AL 35294 USA.
C3 University of Alabama System; University of Alabama Birmingham; United
   States Department of Agriculture (USDA); Tufts University; University of
   Minnesota System; University of Minnesota Twin Cities; Washington
   University (WUSTL); Utah System of Higher Education; University of Utah;
   University of Alabama System; University of Alabama Birmingham
RP Kabagambe, EK (corresponding author), Univ Alabama, Sch Publ Hlth, Dept Epidemiol, Birmingham, AL 35294 USA.
EM edmondk@uab.edu
RI Glasser, Stephen/S-5996-2019; Kabagambe, Edmond/A-3147-2008; Ordovas,
   Jose/B-8727-2013
OI Ordovas, Jose/0000-0002-7581-5680; Kabagambe,
   Edmond/0000-0002-8993-3186; Glasser, Stephen/0000-0001-9620-6406;
   Arnett, Donna/0000-0003-2219-657X; Tsai, Michael/0000-0001-7553-3408
FU NHLBI [U01HL072524-04]
FX Grant/funding support: This study was funded by NHLBI grant number
   U01HL072524-04.
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NR 25
TC 32
Z9 38
U1 0
U2 2
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0021-9150
J9 ATHEROSCLEROSIS
JI Atherosclerosis
PD APR
PY 2009
VL 203
IS 2
BP 633
EP 639
DI 10.1016/j.atherosclerosis.2008.08.005
PG 7
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 437CW
UT WOS:000265464800049
PM 18804210
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Akheratdoost, V
   Panahi, N
   Safi, S
   Mojab, F
   Akbari, G
AF Akheratdoost, Vahid
   Panahi, Negar
   Safi, Shahabeddin
   Mojab, Faraz
   Akbari, Ghasem
TI Protective effects of silymarin-loaded chitosan nanoparticles in the
   diet-induced hyperlipidemia rat model
SO IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
LA English
DT Article
DE Antiobesity; Body mass index; Chitosan; Dyslipidemia; High cholesterol
   diet; HOMA-IR; Silymarin
ID NEUROPEPTIDE-Y; QUERCETIN; SILIBININ; RECEPTOR; EXTRACT; OBESITY; STRESS
AB Objective(s): Obesity is a metabolic syndrome that leads to many chronic diseases worldwide. In this study, we investigate the antihyperlipidemic activities of chitosan nanoparticles (CH NPs) on silymarin (SIL) as a carrier in the drug delivery system that can improve some biochemical parameters and hormones in the model of hyperlipidemic rats receiving a high-fat diet (HFD). Materials and Methods: Physicochemical characterization of silymarin-loaded chitosannanoparticles (CH-SIL NPs) was done by Fourier-transform infrared (FTIR) spectroscopy, dynamic light scattering (DLS), and drug loading efficiency (LE). Diet-induced hyperlipidemic rats were treated with SIL (15 mg/kg/day) and CH-SIL NPs(15 mg/kg/day) for twelve weeks orally daily. The body weight loss (BW), food consumption, serum total cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDL), levels of fasting blood glucose (FBG) in serum, serum insulin, cortisol, testosterone, and brain neuropeptide Y (NPY), Y1 and Y5 receptor mRNA expression were analyzed. Results: A significant reduction in BW and food consumption from 417 +/- 16 g and 33 +/- 1.03 in group HFD to 338 +/- 10 g and 17.33 +/- 1.02 in group CHS+HFD was observed, respectively. This data revealed that CH-SIL NPs improved hyperlipidemia, hyperinsulinemia, and hyperglycemia, reduced serum cortisol, and down-regulated NPY and Y1R with a significant increase in HDL and testosterone hormones compared to the control group. Conclusion: The developed Sil-loaded CH NPs were good agents for improving efficacy. It is the first report of the proposed weight loss mechanism of SIL CH NPs, thereby providing information about the anti-hyperlipidemic and antihyperglycemic effects of silymarin-loaded chitosan nanoparticles, a natural food with proper effects against metabolic disorders in case of hyperlipidemia that may lead to obesity and up-regulation of brain NPY.
C1 [Akheratdoost, Vahid; Panahi, Negar] Islamic Azad Univ, Dept Vet Basic Sci, Sci & Res Branch, Tehran, Iran.
   [Safi, Shahabeddin] Islamic Azad Univ, Dept Vet Pathobiol, Sci & Res Branch, Tehran, Iran.
   [Mojab, Faraz] Shahid Beheshti Univ Med Sci, Sch Pharm, Dept Pharmacognosy, Tehran, Iran.
   [Akbari, Ghasem] Islamic Azad Univ, Dept Vet Clin Sci, Sci & Res Branch, Tehran, Iran.
C3 Islamic Azad University; Islamic Azad University; Shahid Beheshti
   University Medical Sciences; Islamic Azad University
RP Panahi, N (corresponding author), Islamic Azad Univ, Dept Vet Basic Sci, Sci & Res Branch, Tehran, Iran.
EM n.panahi@srbiau.ac.ir
RI Panahi, Negar/J-1807-2019
FU Science and Research Branch kindly, Islamic Azad University, Tehran,
   Iran
FX The Science and Research Branch kindly, Islamic Azad University, Tehran,
   Iran, supported this work. The results presented in this paper were part
   of a student thesis.
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NR 41
TC 1
Z9 1
U1 2
U2 4
PU MASHHAD UNIV MED SCIENCES
PI MASHHAD
PA VICE-CHANCELLOR FOR RES CTR OFF IJBMS, DANESHGAH ST, PO BOX 9138813944 -
   445, MASHHAD, 00000, IRAN
SN 2008-3866
EI 2008-3874
J9 IRAN J BASIC MED SCI
JI Iran. J. Basic Med. Sci.
PD JUN
PY 2024
VL 27
IS 6
BP 725
EP 732
DI 10.22038/IJBMS.2024.74490.16179
PG 8
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA LN1H6
UT WOS:001187385400009
PM 38645495
DA 2025-06-11
ER

PT J
AU Du, XE
   Cui, ZJ
   Zhang, R
   Zhao, KL
   Wang, LM
   Yao, JH
   Liu, SM
   Cai, CJ
   Cao, YC
AF Du, Xue'er
   Cui, Zhijie
   Zhang, Rui
   Zhao, Keliang
   Wang, Lamei
   Yao, Junhu
   Liu, Shimin
   Cai, Chuanjiang
   Cao, Yangchun
TI The Effects of Rumen-Protected Choline and Rumen-Protected Nicotinamide
   on Liver Transcriptomics in Periparturient Dairy Cows
SO METABOLITES
LA English
DT Article
DE perinatal cows; rumen-protected choline; rumen-protected nicotinamide;
   transcriptomics; metabolic syndrome
ID TRANSITION PERIOD; MILK-PRODUCTION; RETINOIC ACID; SUPPLEMENTATION;
   DISEASE; PERFORMANCE; METABOLISM; EXPRESSION; FIBROSIS; LACTATION
AB To investigate the effects of rumen-protected choline (RPC) and rumen-protected nicotinamide (RPM) on liver metabolic function based on transcriptome in periparturient dairy cows, 10 healthy Holstein dairy cows with similar parity were allocated to RPC and RPM groups (n = 5). The cows were fed experimental diets between 14 days before and 21 days after parturition. The RPC diet contained 60 g RPC per day, and the RPM diet contained 18.7 g RPM per day. Liver biopsies were taken 21 days after calving for the transcriptome analysis. A model of fat deposition hepatocytes was constructed using the LO2 cell line with the addition of NEFA (1.6 mmol/L), and the expression level of genes closely related to liver metabolism was validated and divided into a CHO group (75 mu mol/L) and a NAM group (2 mmol/L). The results showed that the expression of a total of 11,023 genes was detected and clustered obviously between the RPC and RPM groups. These genes were assigned to 852 Gene Ontology terms, the majority of which were associated with biological process and molecular function. A total of 1123 differentially expressed genes (DEGs), 640 up-regulated and 483 down-regulated, were identified between the RPC and RPM groups. These DEGs were mainly correlated with fat metabolism, oxidative stress and some inflammatory pathways. In addition, compared with the NAM group, the gene expression level of FGF21, CYP26A1, SLC13A5, SLCO1B3, FBP2, MARS1 and CDH11 in the CHO group increased significantly (p < 0.05). We proposed that that RPC could play a prominent role in the liver metabolism of periparturient dairy cows by regulating metabolic processes such as fatty acid synthesis and metabolism and glucose metabolism; yet, RPM was more involved in biological processes such as the TCA cycle, ATP generation and inflammatory signaling.
C1 [Du, Xue'er; Cui, Zhijie; Zhang, Rui; Zhao, Keliang; Wang, Lamei; Yao, Junhu; Cai, Chuanjiang; Cao, Yangchun] Northwest A&F Univ, Coll Anim Sci & Technol, Xianyang 712100, Peoples R China.
   [Liu, Shimin] Univ Western Australia, UWA Inst Agr, Crawley, WA 6009, Australia.
C3 Northwest A&F University - China; University of Western Australia
RP Cai, CJ; Cao, YC (corresponding author), Northwest A&F Univ, Coll Anim Sci & Technol, Xianyang 712100, Peoples R China.
EM shimin.liu@uwa.edu.au; caichj@nwafu.edu.cn; caoyangchun@126.com
RI wang, lamei/NKP-8827-2025
OI Cao, Yangchun/0000-0003-1033-2909
FU National Natural Science Foundation of China [31972592]; National Key
   Research and Development Program [2021YFD1300301]; Science and
   Technological Project of Shaanxi Province [2021NY-019]
FX This research was funded by the National Natural Science Foundation of
   China (31972592), the National Key Research and Development Program
   (2021YFD1300301) and the Science and Technological Project of Shaanxi
   Province (2021NY-019).
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NR 75
TC 7
Z9 8
U1 0
U2 13
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2218-1989
J9 METABOLITES
JI Metabolites
PD APR 26
PY 2023
VL 13
IS 5
AR 594
DI 10.3390/metabo13050594
PG 16
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA H6MC0
UT WOS:000997071300001
PM 37233635
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Tang, JY
   Liu, KY
   Eshak, ES
   Cui, RZ
   Sakaniwa, R
   Imano, H
   Dong, JY
   Iso, H
AF Tang, Jingyun
   Liu, Keyang
   Eshak, Ehab S.
   Cui, Renzhe
   Sakaniwa, Ryoto
   Imano, Hironori
   Dong, Jia-Yi
   Iso, Hiroyasu
TI Association between Serum Uric Acid and Impaired Endothelial Function:
   The Circulatory Risk in Communities Study
SO JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
LA English
DT Article
DE &nbsp; Uric acid; Endothelial dysfunction; Flow -mediated dilation;
   Japanese; Cross-sectional study
ID FLOW-MEDIATED VASODILATION; CARDIOVASCULAR RISK; METABOLIC SYNDROME;
   OXIDATIVE STRESS; BRACHIAL-ARTERY; BLOOD-PRESSURE; HYPERURICEMIA;
   DYSFUNCTION; ATHEROSCLEROSIS; PROLIFERATION
AB Aims: Higher serum uric acid (UA) may impair endothelial function. However, population-based evidence examining the association between serum UA levels and endothelial function remains to be limited. Thus, in this study, we aimed to investigate this in the general population. Methods: In this cross-sectional study, 1000 participants (496 males and 504 females), aged 30-79 years, free from a history of gout, have undergone both serum UA and brachial artery flow-mediated dilation (FMD) measurements. Participants were divided into four groups based on serum UA quartiles. Logistic regression models were used to calculate odds ratios (ORs) for low FMD according to the serum UA levels. Results: In total, 203 participants (138 males and 65 females) with %FMD <= 5.0% were identified to have endothelial dysfunction. The multivariable OR of low FMD for highest quartiles vs. lowest quartiles was 2.39 (95% confidence interval [CI]: 1.32-4.34), while OR per 1-standard deviation (SD) increment was 1.28 (95% CI: 1.04-1.56). The positive association was noted to be more evident in females (OR per 1-SD increment: 1.46; 95% CI: 1.08-1.96) than in males and confined to individuals not using antihypertensive medications. The ORs per 1-SD increment were 1.01 (95% CI: 0.68-1.50) among individuals using antihypertensive medications and 1.43 (95% CI: 1.12-1.81) among individuals not using antihypertensive medications. Conclusion: Higher serum UA was positively associated with the prevalence of endothelial dysfunction in samples of the general Japanese population and that positive association was confined to individuals not using antihypertensive medications.
C1 [Tang, Jingyun; Liu, Keyang; Eshak, Ehab S.; Sakaniwa, Ryoto; Imano, Hironori; Dong, Jia-Yi; Iso, Hiroyasu] Osaka Univ, Grad Sch Med, Dept Social Med, Publ Hlth, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan.
   [Eshak, Ehab S.] Minia Univ, Fac Med, Dept Publ Hlth & Prevent Med, Al Minya, Egypt.
   [Cui, Renzhe] Okanami Gen Hosp, Dept Internal Med, Iga, Mie, Japan.
C3 The University of Osaka; Egyptian Knowledge Bank (EKB); Minia University
RP Iso, H (corresponding author), Osaka Univ, Grad Sch Med, Dept Social Med, Publ Hlth, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan.
EM iso@pbhel.med.osaka-u.ac.jp
RI Dong, Jia-Yi/ABF-5541-2021; Tang, Jingyun/KCZ-0453-2024; Dong,
   Jia-Yi/ABG-7113-2021
OI Dong, Jia-Yi/0000-0002-8667-6946
FU Ministry of Health, Education, Culture, Sports, Science and Technology,
   Japan;  [24590790]; Grants-in-Aid for Scientific Research [21KK0168]
   Funding Source: KAKEN
FX The study was supported by a Grant-in-Aid for Scientific Research C (No.
   24590790 in 2012-2014) from the Ministry of Health, Education, Culture,
   Sports, Science and Technology, Japan.
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NR 46
TC 5
Z9 7
U1 0
U2 5
PU JAPAN ATHEROSCLEROSIS SOC
PI TOKYO
PA NICHINAI-KAIKAN B1, 3-28-8 HONGO BUNKYO-KU, TOKYO, 113-0033, JAPAN
SN 1340-3478
EI 1880-3873
J9 J ATHEROSCLER THROMB
JI J. Atheroscler. Thromb.
PY 2022
VL 29
IS 10
BP 1534
EP 1546
DI 10.5551/jat.63199
PG 13
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 5H2HA
UT WOS:000867503400001
PM 34853212
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Czókolyová, M
   Pusztai, A
   Végh, E
   Horváth, A
   Szentpéteri, A
   Hamar, A
   Szamosi, S
   Hodosi, K
   Domján, A
   Szántó, S
   Kerekes, G
   Seres, I
   Harangi, M
   Paragh, G
   Szekanecz, É
   Szekanecz, Z
   Szucs, G
AF Czokolyova, Monika
   Pusztai, Anita
   Vegh, Edit
   Horvath, Agnes
   Szentpeteri, Anita
   Hamar, Attila
   Szamosi, Szilvia
   Hodosi, Katalin
   Domjan, Andrea
   Szanto, Sandor
   Kerekes, Gyorgy
   Seres, Ildiko
   Harangi, Mariann
   Paragh, Gyorgy
   Szekanecz, Eva
   Szekanecz, Zoltan
   Szucs, Gabriella
TI Changes of Metabolic Biomarker Levels upon One-Year Anti-TNF-α Therapy
   in Rheumatoid Arthritis and Ankylosing Spondylitis: Associations with
   Vascular Pathophysiology
SO BIOMOLECULES
LA English
DT Article
DE rheumatoid arthritis; ankylosing spondylitis; biologic therapy;
   metabolic biomarkers; lipids; adipokines
ID INTIMA-MEDIA THICKNESS; CARDIOVASCULAR-DISEASE; PARAOXONASE ACTIVITY;
   OXIDATIVE STRESS; SUBCLINICAL ATHEROSCLEROSIS; OVERWEIGHT PATIENTS;
   PLASMA-LEVELS; MYELOPEROXIDASE; INFLAMMATION; ADIPONECTIN
AB Background: Cardiovascular (CV) morbidity, mortality, and metabolic syndrome are associated with rheumatoid arthritis (RA) and ankylosing spondylitis (AS). Here, lipids and other metabolic markers in relation to vascular function and clinical markers were evaluated in RA and AS patients undergoing one-year anti-TNF therapy. Patients and methods: Fifty-three patients including 36 RA patients treated with either etanercept (ETN) or certolizumab pegol (CZP) and 17 AS patients treated with ETN were included in a 12-month follow-up study. Various lipids, paraoxonase (PON) and arylesterase (ARE) activities, myeloperoxidase (MPO) and adipokine levels were determined overtime. Ultrasonography was performed to determine flow-mediated vasodilation (FMD), common carotid intima-media thickness (ccIMT), and arterial pulse-wave velocity (PWV) in all patients. All assessments were performed at baseline and 6 and 12 months after treatment initiation. Results: Anti-TNF therapy decreased ARE activity, MPO, adiponectin, and chemerin levels after 12 months (p < 0.05). Lipids, PON activity, and leptin remained unchanged. Regression analyses suggested variable associations of IMT, PWV, and FMD with ARE, MPO, leptin, and lipids (p < 0.05). On the other hand, these metabolic parameters were significantly associated with disease duration, CV history, CRP, obesity, PWV, and IMT (p < 0.05). One-year anti-TNF treatment together with baseline leptin (p = 0.039) or CRP (p = 0.016) levels determined 12 months of lipid changes overtime. TNF inhibition together with baseline disease activity determined ARE activity changes (p = 0.046). Anti-TNF therapy and baseline chemerin levels determined IMT changes overtime (p = 0.003). Conclusions: Assessment of various metabolic parameters together with disease activity, CRP, and ultrasound-based techniques may exert additional value in determining CV burden and in monitoring the effects of biologics on preclinical vascular pathophysiology.</p>
C1 [Czokolyova, Monika; Pusztai, Anita; Vegh, Edit; Horvath, Agnes; Hamar, Attila; Szamosi, Szilvia; Hodosi, Katalin; Domjan, Andrea; Szanto, Sandor; Szekanecz, Zoltan; Szucs, Gabriella] Univ Debrecen, Fac Med, Div Rheumatol, H-4031 Debrecen, Hungary.
   [Szentpeteri, Anita; Seres, Ildiko; Harangi, Mariann; Paragh, Gyorgy] Univ Debrecen, Fac Med, Dept Med, Div Metab Dis, H-4031 Debrecen, Hungary.
   [Szanto, Sandor] Univ Debrecen, Fac Med, Dept Sports Med, H-4031 Debrecen, Hungary.
   [Kerekes, Gyorgy] Univ Debrecen, Fac Med, Dept Med, Intens Care Unit, H-4031 Debrecen, Hungary.
   [Szekanecz, Eva] Univ Debrecen, Fac Med, Dept Oncol, H-4031 Debrecen, Hungary.
C3 University of Debrecen; University of Debrecen; University of Debrecen;
   University of Debrecen; University of Debrecen
RP Szekanecz, Z (corresponding author), Univ Debrecen, Fac Med, Div Rheumatol, H-4031 Debrecen, Hungary.
EM monika.czokolyova@gmail.com; anita.pusztai01@gmail.com;
   veghe22@gmail.com; kis.horvathagi@gmail.com;
   szentpeteri.anita@gmail.com; attilahamar.2010@gmail.com;
   szamosi.szilvi@gmail.com; khodosi@gmail.com; domjan.andrea@gmail.com;
   szanto.sandor@med.unideb.hu; gkerekesg@gmail.com;
   seres@internal.med.unideb.hu; harangi@belklinika.com;
   paragh.gyorgy@med.unideb.hu; szevadr17@gmail.com;
   szekanecz.zoltan@med.unideb.hu; szucs.gabriella@med.unideb.hu
RI Szekanecz, Zoltán/GXN-0235-2022; Harangi, Mariann/ACY-2278-2022; Hamar,
   Attila/HRA-4166-2023
OI Hamar, Attila/0000-0002-3399-4801
FU European Union; State of Hungary; European Social Fund
   [TAMOP-4.2.4.A/2-11/1-2012-0001]; European Union
   [GINOP-2.3.2-15-2016-00050, GINOP-2.3.2-15-2016-00005]; Pfizer
   [WS1695414]
FX This research was supported by the European Union and the State of
   Hungary and co-financed by the European Social Fund in the framework of
   TAMOP-4.2.4.A/2-11/1-2012-0001 `National Excellence Program' (Z.S.); by
   the European Union grants GINOP-2.3.2-15-2016-00050 (Z.S.) and
   GINOP-2.3.2-15-2016-00005 (G.P.); and by the Pfizer Investigator
   Initiated Research Grant No. WS1695414 (Z.S.).
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NR 60
TC 11
Z9 12
U1 1
U2 4
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2218-273X
J9 BIOMOLECULES
JI Biomolecules
PD OCT
PY 2021
VL 11
IS 10
AR 1535
DI 10.3390/biom11101535
PG 15
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA WS3RI
UT WOS:000715101900001
PM 34680168
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Hepsen, S
   Sencar, E
   Sakiz, D
   Akhanli, P
   Ucan, B
   Unsal, I
   Ozbek, M
   Cakal, E
AF Hepsen, Sema
   Sencar, Erkam
   Sakiz, Davut
   Akhanli, Pinar
   Ucan, Bekir
   Unsal, Ilknur
   Ozbek, Mustafa
   Cakal, Erman
TI Serum cortisol level after low dose dexamethasone suppression test may
   be predictive for diabetes mellitus and hypertension presence in obese
   patients: A retrospective study
SO DIABETES RESEARCH AND CLINICAL PRACTICE
LA English
DT Article
DE Cortisol; Dexamethasone suppression test; Diabetes mellitus;
   Hypertension; Obesity
ID BODY-MASS INDEX; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   GLUCOCORTICOIDS; DYSREGULATION; FREQUENCY; SOCIETY; STRESS; HAIR
AB Aims: Obesity, a remarkably increased healthcare problem, accompanies with morbidities including type 2 diabetes mellitus (DM), hypertension, and cardiovascular diseases. Hypothalamic-pituitary-adrenal (HPA) axis alteration is thought to be effective on the background of obesity, even concomitant with DM and hypertension. We aimed to evaluate the negative feedback mechanism of the HPA axis via overnight 1 mg dexamethasone suppression test (DST) and the association of post-1 mg DST cortisol level with DM and hypertension presence in obesity.
   Methods: This study consisted of 402 obese patients who provide suppression after DST. Post-1 mg DST cortisol level and its association with other variables including anthropometric measurements, laboratory test results, hypertension, prediabetes, and DM presence were evaluated. Predictivity of post-1 mg DST for hypertension and DM was investigated.
   Results: We established a significant difference in post-1 mg DST cortisol level when compared patients with and without DM, patients without DM and with prediabetes, patients with prediabetes and DM (p < 0.001 vs. p = 0.003 vs. p = 0.022 respectively). Post-1 mg DST cortisol level was significantly higher in hypertensive patients (p < 0.001). Post-1 mg DST cortisol level had positive correlation with age (r = 0.319, p < 0.001), fasting plasma glucose (r = 0.168, p = 0.001), and HbA1c (r = 0.278, p < 0.001) levels. Logistic regression analyses demonstrated that post-1 mg DST cortisol level is an independent predictor of DM and hypertension presence.
   Conclusion: Cortisol negative feedback mechanism may be altered in obese patients who are complicated with hypertension and DM. Therefore, post-1 mg DST cortisol level can be predictive for hypertension and DM presence in obesity. (C) 2020 Elsevier B.V. All rights reserved.
C1 [Hepsen, Sema; Sencar, Erkam; Akhanli, Pinar; Ucan, Bekir; Unsal, Ilknur; Ozbek, Mustafa; Cakal, Erman] Univ Hlth Sci, Diskapi Yildirim Beyazit Training & Res Hosp, Dept Endocrinol & Metab, Ankara, Turkey.
   [Sakiz, Davut] Mardin State Hosp, Dept Endocrinol & Metab, Mardin, Turkey.
C3 University of Health Sciences Turkey; Diskapi Yildirim Beyazit Training
   & Research Hospital; Mardin State Hospital
RP Hepsen, S (corresponding author), Univ Hlth Sci, Diskapi Yildirim Beyazit Training & Res Hosp, Dept Endocrinol & Metab, Ankara, Turkey.
EM semahepsen@gmail.com
RI Sencar, Muhammed/AAN-8807-2021; Hepsen, Sema/GPK-5321-2022; Ünsal,
   İlknur/AAO-7474-2021; Ustun, Yaprak/KFQ-9767-2024; özbek,
   mustafa/IYS-6564-2023; Sakız, Davut/ADF-0562-2022; akhanli,
   pinar/JKI-3197-2023
OI Sencar, Muhammed Erkam/0000-0001-5581-4886; cakal,
   erman/0000-0003-4455-7276; akhanli, pinar/0000-0002-1662-3363; HEPSEN,
   SEMA/0000-0002-8375-7409
CR Abraham SB, 2013, OBESITY, V21, pE105, DOI 10.1002/oby.20083
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NR 36
TC 13
Z9 14
U1 0
U2 5
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0168-8227
EI 1872-8227
J9 DIABETES RES CLIN PR
JI Diabetes Res. Clin. Pract.
PD MAR
PY 2020
VL 161
SI SI
AR 108081
DI 10.1016/j.diabres.2020.108081
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA KW0GQ
UT WOS:000520852000027
PM 32068098
DA 2025-06-11
ER

PT J
AU SaeidiFard, N
   Djafarian, K
   Shab-Bidar, S
AF SaeidiFard, Nasim
   Djafarian, Kurosh
   Shab-Bidar, Sakineh
TI Fermented foods and inflammation: A systematic review and meta-analysis
   of randomized controlled trials
SO CLINICAL NUTRITION ESPEN
LA English
DT Review
DE Supplementation; Fermented foods; C-reactive protein (CRP); Interleukin
   (IL)-6; Tumor necrosis factor (TNF)-alpha; Meta-analysis
ID C-REACTIVE PROTEIN; TYPE-2 DIABETES-MELLITUS; DOUBLE-BLIND; OXIDATIVE
   STRESS; RED WINE; PROBIOTIC SUPPLEMENTATION; ALCOHOL-CONSUMPTION; YOGURT
   CONSUMPTION; METABOLIC SYNDROME; BIOMARKERS
AB Objective: The effect of fermented foods consumption on inflammation has been investigated in several studies, but findings are inconsistent. Therefore we conducted a meta-analysis to examine the effect of fermented foods on inflammatory biomarkers including C-reactive protein (CRP), interleukin (IL)-6 and tumor necrosis factor (TNF)-alpha in the general adult population.
   Design: systematic review and meta-analysis.
   Methods: In this systematic review and meta-analysis, randomized controlled trials in the general adult population comparing fermented foods with a control product were searched from two literature databases (PubMed and Scopus) up to June 4, 2019. Trials with mean difference (MD) of 95% confidence interval (CI) were pooled using random effect model. Heterogeneity was assessed using Cochran's Q and I-2 tests. Subgroup analysis was applied to define possible sources of heterogeneity.
   Results: The search strategy identified 3293 documents. Overall, 26 publications with 1461 people met the inclusion criteria. Our results indicated that intake of fermented foods could reduce serum TNF-alpha levels ((WMD = -8.26, 95% CI: -14.61, -1.91, p = 0.01; I-2 = 99.9%, p < 0.001)). However, no change was observed in serum levels of CRP ((WMD = -0.21, 95% CI: -0.47, 0.05, p = 0.11), I-2 = 93.8%, p < 0.001) and IL-6 ((WMD = 0.31, 95% CI:-3.79, 4.43, p = 0.88), I-2 = 99.3%, p < 0.001).
   Conclusion: Our findings showed that intake of fermented foods did not improve serum CRP and IL-6. We observed a reduction in pooled effect of TNF-alpha following intake of fermented foods. (c) 2019 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights reserved.
C1 [SaeidiFard, Nasim; Shab-Bidar, Sakineh] Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Community Nutr, 44 Hojjat Dost Alley,Naderi St,Keshavarz Blvd, Tehran, Iran.
   [Djafarian, Kurosh] Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Clin Nutr, Tehran, Iran.
C3 Tehran University of Medical Sciences; Tehran University of Medical
   Sciences
RP Shab-Bidar, S (corresponding author), Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Community Nutr, 44 Hojjat Dost Alley,Naderi St,Keshavarz Blvd, Tehran, Iran.
EM nasim.saeidifard@gmail.com; kdjafarian@tums.ac.ir;
   s_shabbidar@tums.ac.ir
RI djafarian, kurosh/D-5563-2018; Shab-Bidar, Sakineh/H-9525-2017
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NR 78
TC 15
Z9 16
U1 0
U2 14
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2405-4577
J9 CLIN NUTR ESPEN
JI Clin. Nutr. ESPEN
PD FEB
PY 2020
VL 35
BP 30
EP 39
DI 10.1016/j.clnesp.2019.10.010
PG 10
WC Nutrition & Dietetics
WE Emerging Sources Citation Index (ESCI)
SC Nutrition & Dietetics
GA KG1ZC
UT WOS:000509739500004
PM 31987119
DA 2025-06-11
ER

PT J
AU Jiang, L
   Wang, K
   Lo, K
   Zhong, YY
   Yang, AM
   Fang, XX
   Akezhuoli, H
   Song, ZJ
   Chen, LY
   An, P
   Xu, MQ
   Min, JX
   Wang, FD
AF Jiang, Li
   Wang, Kai
   Lo, Kenneth
   Zhong, Yueyang
   Yang, Aimin
   Fang, Xuexian
   Akezhuoli, Hailati
   Song, Zijun
   Chen, Liyun
   An, Peng
   Xu, Mingqing
   Min, Junxia
   Wang, Fudi
TI Sex-Specific Association of Circulating Ferritin Level and Risk of Type
   2 Diabetes: A Dose-Response Meta-Analysis of Prospective Studies
SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Article
ID BODY IRON STORES; SOLUBLE TRANSFERRIN RECEPTOR; SERUM FERRITIN;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; OXIDATIVE STRESS; PLASMA
   FERRITIN; PUBLICATION BIAS; DEFENSE STATUS; FOLLOW-UP
AB Context: Although the role of iron in the development of type 2 diabetes (T2D) has long been a concern, prospective studies directly linking body iron stores to T2D risk in a sex-dependent context have been inconsistent.
   Objective: A systematic meta-analysis was conducted to explore the sex-specific association of circulating ferritin with T2D risk.
   Data Sources: We searched PubMed, Web of Science, and EMBASE databases to identify available prospective studies through 1 August 2018.
   Results: Fifteen prospective studies comprising 77,352 participants and 18,404 patients with T2D, aged 20 to 80 years, and with similar to 3 to 17 years of follow-up were identified. For each 100-mu g/L increment in ferritin levels of overall participants, T2D risk increased by 22% (RR, 1.22; 95% CI, 1.14 to 1.31). Of note, major heterogeneities by sex were identified, with increased ferritin level having an apparently greater effect on T2D risk in women (RR, 1.53; 95% CI, 1.29 to 1.82) than in men (RR, 1.21; 95% CI, 1.15 to 1.27) after exclusion of a study with high heterogeneity (41,512 men and 6974 women for sex-specific analyses; P = 0.020 for sex difference). Further nonlinear analysis between circulating ferritin and T2D risk also showed sex-dimorphic association in that the T2D risk of women was twice as strong in magnitude as that of men at the same ferritin level.
   Conclusions: Greater circulating ferritin levels were independently associated with increased T2D risk, which appeared stronger among women than men. Our findings provide prospective evidence for further testing of the utility of ferritin levels in predicting T2D risk in a sex-specific manner.
C1 [Jiang, Li; Wang, Kai; Zhong, Yueyang; Fang, Xuexian; Akezhuoli, Hailati; Song, Zijun; Chen, Liyun; Min, Junxia; Wang, Fudi] Zhejiang Univ, Affiliated Hosp 1, Sch Publ Hlth, Inst Translat Med,Sch Med, Hangzhou 310058, Zhejiang, Peoples R China.
   [Jiang, Li; An, Peng; Wang, Fudi] China Agr Univ, Beijing Adv Innovat Ctr Food Nutr & Human Hlth, Beijing 100193, Peoples R China.
   [Jiang, Li; Wang, Fudi] Zhengzhou Univ, Affiliated Hosp 1, Sch Publ Hlth, Zhengzhou 450000, Henan, Peoples R China.
   [Lo, Kenneth] Guangdong Prov Peoples Hosp, Guangdong Acad Med Sci, Dept Cardiol, Guangzhou 510080, Guangdong, Peoples R China.
   [Lo, Kenneth] Guangdong Prov Peoples Hosp, Guangdong Acad Med Sci, Dept Endocrinol, Guangzhou 510080, Guangdong, Peoples R China.
   [Lo, Kenneth] Brown Univ, Ctr Global Cardiometab Hlth, Dept Epidemiol, Providence, RI 02912 USA.
   [Yang, Aimin] Chinese Univ Hong Kong, Hong Kong Inst Diabet & Obes, Kong Kong 999077, Peoples R China.
   [Xu, Mingqing] Shanghai Jiao Tong Univ, Bio X Inst, Key Lab Genet Dev & Neuropsychiat Disorders, Minist Educ, Shanghai 200030, Peoples R China.
C3 Zhejiang University; China Agricultural University; Zhengzhou
   University; Guangdong Academy of Medical Sciences & Guangdong General
   Hospital; Southern Medical University - China; Guangdong Academy of
   Medical Sciences & Guangdong General Hospital; Southern Medical
   University - China; Brown University; Chinese University of Hong Kong;
   Ministry of Education - China; Shanghai Jiao Tong University
RP Xu, MQ (corresponding author), Shanghai Jiao Tong Univ, Bio X Inst, Key Lab Genet Dev & Neuropsychiat Disorders, Minist Educ, Shanghai 200030, Peoples R China.; Min, JX; Wang, FD (corresponding author), Zhejiang Univ, Affiliated Hosp 1, Sch Publ Hlth, Sch Med, 866 Yuhangtang Rd, Hangzhou 310058, Zhejiang, Peoples R China.
EM mingqingxu@sjtu.edu.cn; Junxiamin@zju.edu.cn; fwang@zju.edu.cn
RI Fang, Xuexian/Z-4786-2019; Zhong, Yueyang/GQI-2317-2022; Yang,
   Aimin/D-8344-2015; An, Peng/GWZ-9176-2022; Lo, Kenneth/ABB-6248-2020; ,
   Kenneth/C-6537-2014; Wang, Fudi/L-7888-2018
OI Jiang, Li/0000-0002-5628-2727; An, Peng/0000-0002-0421-0035; ,
   Kenneth/0000-0003-4624-2737; Wang, Fudi/0000-0001-8730-0003
FU National Natural Science Foundation of China [31530034, 31570791,
   91542205]; National Key Research and Development Program
   [2018YFA0507802, 2018YFA0507801]
FX This study was supported by research grants from the National Natural
   Science Foundation of China (31530034 to F.W.; 31570791 and 91542205 to
   J.M.) and the National Key Research and Development Program
   (2018YFA0507802 to F.W.; 2018YFA0507801 to J. M.).
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NR 80
TC 66
Z9 66
U1 0
U2 12
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0021-972X
EI 1945-7197
J9 J CLIN ENDOCR METAB
JI J. Clin. Endocrinol. Metab.
PD OCT
PY 2019
VL 104
IS 10
BP 4539
EP 4551
DI 10.1210/jc.2019-00495
PG 13
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA JD1CH
UT WOS:000489712300033
PM 31074789
OA Bronze
DA 2025-06-11
ER

PT J
AU Kim, EJ
   Jeong, MH
   Kim, JH
   Ahn, TH
   Seung, KB
   Oh, DJ
   Kim, HS
   Gwon, HC
   Seong, IW
   Hwang, KK
   Chae, SC
   Kim, KB
   Kim, YJ
   Cha, KS
   Oh, SK
   Chae, JK
AF Kim, Eun Jung
   Jeong, Myung Ho
   Kim, Ju Han
   Ahn, Tae Hoon
   Seung, Ki Bae
   Oh, Dong Joo
   Kim, Hyo-Soo
   Gwon, Hyeon Cheol
   Seong, In Whan
   Hwang, Kyung Kuk
   Chae, Shung Chull
   Kim, Kwon-Bae
   Kim, Young Jo
   Cha, Kwang Soo
   Oh, Seok Kyu
   Chae, Jei Keon
CA KAMIR-NIH Registry Investigators
TI Clinical impact of admission hyperglycemia on in-hospital mortality in
   acute myocardial infarction patients
SO INTERNATIONAL JOURNAL OF CARDIOLOGY
LA English
DT Article
DE Myocardial infarction; Hyperglycemia; Diabetes mellitus
ID BLOOD-GLUCOSE VALUES; STRESS HYPERGLYCEMIA; METABOLIC SYNDROME;
   DIABETES-MELLITUS; FATTY-ACIDS; ASSOCIATION; REPERFUSION; DIAGNOSIS;
   ISCHEMIA; HUMANS
AB Background: Acute hyperglycemia on admission is common in acute myocardial infarction (AMI) patients regardless of diabetic status, and is known as one of prognostic factors. However, the effect of hyperglycemia on non-diabetic patients is still on debate.
   Methods: A total of 12,625 AMI patients (64.0 +/- 12.6 years, 26.1% female) who were enrolled in Korea Acute Myocardial Infarction Registry-National Institute of Health between November 2011 and December 2015, were classified into 4367 diabetes (65.4 +/- 11.6 years, 30.4% female) and 8228 non-diabetes (63.3 +/- 13 years, 23.9% female). Patients were analyzed for in-hospital clinical outcome according to admission hyperglycemic status.
   Results: In diabetic patients, independent predictors of in-hospital mortality were old age, high HbA(1)C, pre-Thrombolysis In Myocardial Infarction (TIMI) flow 0, left ventricle ejection fraction < 40%, cardiogenic shock and ventricular tachycardia. In non-diabetic patients, independent predictors of in-hospital mortality were old age, high admission glucose (>= 200 mg/dL), pre TIMI flow 0, failed percutaneous coronary intervention, low left ventricle ejection fraction < 40%, cardiogenic shock, stent thrombosis and decreased Hb >= 5 g/dL. In hospital mortality was significantly higher in diabetic patients compared to non-diabetic patients (5.0% vs. 3.4%, p < 0.001). However, non-diabetic patients with hyperglycemia have significantly higher mortality compared to diabetic patients (17.4% vs. 7.2%, p < 0.001). Comorbidity including cardiogenic shock (p < 0.001), cerebral hemorrhage (p = 0.012), decreased Hb = 5 g/dL (p = 0.013), atrioventricular block (p < 0.001) and ventricular tachycardia (p = 0.007) was higher in non-diabetic with hyperglycemia than in diabetic patients.
   Conclusions: These findings underscore clinical significance of admission hyperglycemia on in-hospital mortality in non-diabetic AMI patients. (C) 2017 Elsevier B.V. All rights reserved.
C1 [Kim, Eun Jung; Jeong, Myung Ho; Kim, Ju Han] Chonnam Natl Univ Hosp, Gwangju, South Korea.
   [Ahn, Tae Hoon] Gachon Univ, Gil Med Ctr, Incheon, South Korea.
   [Seung, Ki Bae] Catholic Univ Korea, Seoul St Marys Hosp, Seoul, South Korea.
   [Oh, Dong Joo] Korea Univ, Guro Hosp, Seoul, South Korea.
   [Kim, Hyo-Soo] Seoul Natl Univ Hosp, Seoul, South Korea.
   [Gwon, Hyeon Cheol] Sungkyunkwan Univ, Samsung Med Ctr, Seoul, South Korea.
   [Seong, In Whan] Chungnam Natl Univ Hosp, Daejeon, South Korea.
   [Hwang, Kyung Kuk] Chungbuk Natl Univ Hosp, Cheongju, South Korea.
   [Chae, Shung Chull] Kyungpook Natl Univ Hosp, Daegu, South Korea.
   [Kim, Kwon-Bae] Keimyung Univ, Dongsan Med Ctr, Daegu, South Korea.
   [Kim, Young Jo] Yeungnam Univ Hosp, Daegu, South Korea.
   [Cha, Kwang Soo] Pusan Natl Univ Hosp, Busan, South Korea.
   [Oh, Seok Kyu] Wonkwang Univ Hosp, Iksan, South Korea.
   [Chae, Jei Keon] Chonbuk Natl Univ Hosp, Jeonju, South Korea.
C3 Chonnam National University; Chonnam National University Hospital;
   Gachon University; Catholic University of Korea; Seoul St. Mary's
   Hospital; Korea University; Korea University Medicine (KU Medicine);
   Seoul National University (SNU); Seoul National University Hospital;
   Sungkyunkwan University (SKKU); Samsung Medical Center; Chungnam
   National University; Chungnam National University Hospital; Chungbuk
   National University; Chungbuk National University Hospital; Kyungpook
   National University (KNU); Kyungpook National University Hospital
   (KNUH); Keimyung University; Yeungnam University; Yeungnam University
   Hospital; Pusan National University; Pusan National University Hospital;
   Wonkwang University; Jeonbuk National University; Jeonbuk National
   University Hospital
RP Jeong, MH (corresponding author), Chonnam Natl Univ Hosp, Korea Acute Myocardial Infarct Registry, 42 Jaebongro, Gwangju 501757, South Korea.; Jeong, MH (corresponding author), Chonnam Natl Univ Hosp, Heart Res Ctr, Korea Minist Hlth & Welf, 42 Jaebongro, Gwangju 501757, South Korea.
EM myungho@chollian.net
RI Kim, Yong/L-8653-2019; Kim, Gou/AAI-1109-2020; 안, 태훈/GON-9067-2022; Kim,
   Hyo/J-2753-2012
OI Seong, In-Whan/0000-0003-4628-0258; Hwang,
   Kyung-Kuk/0000-0003-3464-3023; Jeong, Jin-Ok/0000-0003-0763-4754
FU Research of Korea Centers for Disease Control and Prevention
   [2016-ER6304-00]
FX This research was supported by a fund (2016-ER6304-00) by Research of
   Korea Centers for Disease Control and Prevention.
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NR 39
TC 60
Z9 65
U1 0
U2 6
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0167-5273
EI 1874-1754
J9 INT J CARDIOL
JI Int. J. Cardiol.
PD JUN 1
PY 2017
VL 236
BP 9
EP 15
DI 10.1016/j.ijcard.2017.01.095
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA EW4MV
UT WOS:000402476500003
PM 28126258
DA 2025-06-11
ER

PT J
AU Wang, YJ
   Gao, EH
   Lau, WB
   Wang, Y
   Liu, GZ
   Li, JJ
   Wang, XL
   Yuan, YX
   Koch, WJ
   Ma, XL
AF Wang, Yajing
   Gao, Erhe
   Lau, Wayne Bond
   Wang, Yang
   Liu, Gaizheng
   Li, Jing-Jing
   Wang, Xiaoliang
   Yuan, Yuexing
   Koch, Walter J.
   Ma, Xin-Liang
TI G-Protein-Coupled Receptor Kinase 2-Mediated Desensitization of
   Adiponectin Receptor 1 in Failing Heart
SO CIRCULATION
LA English
DT Article
DE adipokines; heart failure; phosphorylation; receptors, adiponectin
ID INSULIN-RESISTANCE; MYOCARDIAL-INFARCTION; SKELETAL-MUSCLE;
   OXIDATIVE/NITRATIVE STRESS; PLASMA ADIPONECTIN; METABOLIC SYNDROME;
   FAILURE; MECHANISMS; DYSFUNCTION; REPERFUSION
AB Background-Phosphorylative desensitization of G-protein-coupled receptors contributes significantly to post-myocardial infarction (MI) remodeling and heart failure (HF). Here, we determined whether adiponectin receptors (AdipoRs) 1 and 2 (the 7-transmembrane domain-containing receptors mediating adiponectin functions) are phosphorylatively modified and functionally impaired after MI.
   Methods and Results-Post-MI HF was induced by coronary artery occlusion. Receptor phosphorylation, kinase expression, and adiponectin function were determined via in vivo, ex vivo, and in vitro models. AdipoR1 and AdipoR2 are not phosphorylated in the normal heart. However, AdipoR1 was significantly phosphorylated after MI, peaking at 7 days and remaining significantly phosphorylated thereafter. The extent of post-MI AdipoR1 phosphorylation positively correlated with the expression level of GPCR kinase (GRK) 2, the predominant GRK isoform upregulated in the failing heart. Cardiac-specific GRK2 knockout virtually abolished post-MI AdipoR1 phosphorylation, whereas virus-mediated GRK2 overexpression significantly phosphorylated AdipoR1 and blocked adiponectin metabolic-regulatory/anti-inflammatory signaling. Mass spectrometry identified serine-7, threonine-24, and threonine-53 (residues located in the n-terminal intracellular AdipoR1 region) as the GRK2 phosphorylation sites. Ex vivo experiments demonstrated that adenosine monophosphate-activated protein kinase activation and the anti-tumor necrosis factor-alpha effect of adiponectin were significantly inhibited in cardiomyocytes isolated from nonischemic area 7 days after MI. In vivo experiments demonstrated that acute adiponectin administration-induced cardiac GLUT4 translocation and endothelial nitric oxide synthase phosphorylation were blunted 7 days after MI. Continuous adiponectin administration beginning 7 days after MI failed to protect the heart from adverse remodeling and HF progression. Finally, cardiac-specific GRK2 knockdown restored the cardioprotective effect of adiponectin.
   Conclusion-AdipoR1 is phosphorylatively modified and desensitized by GRK2 in failing cardiomyocytes, contributing to post-MI remodeling and HF progression.
C1 [Wang, Yajing; Lau, Wayne Bond; Wang, Yang; Liu, Gaizheng; Li, Jing-Jing; Wang, Xiaoliang; Yuan, Yuexing; Ma, Xin-Liang] Thomas Jefferson Univ, Dept Emergency Med, Philadelphia, PA 19107 USA.
   [Ma, Xin-Liang] Thomas Jefferson Univ, Dept Med, Ctr Translat Med, Philadelphia, PA 19107 USA.
   [Gao, Erhe; Koch, Walter J.] Temple Univ, Ctr Translat Med, Philadelphia, PA 19122 USA.
C3 Thomas Jefferson University; Thomas Jefferson University; Pennsylvania
   Commonwealth System of Higher Education (PCSHE); Temple University
RP Ma, XL (corresponding author), Thomas Jefferson Univ, Dept Med, 1025 Walnut St,Coll Bldg 808, Philadelphia, PA 19107 USA.
EM yajing.wang@jefferson.edu; xin.ma@jefferson.edu
RI Koch, Walter/LKK-1594-2024; li, jingjing/KCY-6826-2024
OI Lau, Wayne Bond/0000-0002-8064-8290
FU National Institutes of Health [HL-096686, HL-123404]; American Diabetes
   Association [1-15-BS-122, 1-14-BS-228]
FX This research was supported by National Institutes of Health grants
   HL-096686 and HL-123404, American Diabetes Association grant 1-15-BS-122
   (Dr Ma), and American Diabetes Association grant 1-14-BS-228 (Dr Yajing
   Wang).
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NR 47
TC 37
Z9 40
U1 0
U2 17
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0009-7322
EI 1524-4539
J9 CIRCULATION
JI Circulation
PD APR 21
PY 2015
VL 131
IS 16
BP 1392
EP 1404
DI 10.1161/CIRCULATIONAHA.114.015248
PG 13
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA CG4FT
UT WOS:000353240800010
PM 25696921
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Chen, SH
   Zhao, XL
   Ran, L
   Wan, J
   Wang, XF
   Qin, Y
   Shu, FR
   Gao, YX
   Yuan, LJ
   Zhang, QY
   Mi, MT
AF Chen, Shihui
   Zhao, Xiaolan
   Ran, Li
   Wan, Jing
   Wang, Xiaofang
   Qin, Yu
   Shu, Furong
   Gao, Yanxiang
   Yuan, Lijia
   Zhang, Qianyong
   Mi, Mantian
TI Resveratrol improves insulin resistance, glucose and lipid metabolism in
   patients with non-alcoholic fatty liver disease: A randomized controlled
   trial
SO DIGESTIVE AND LIVER DISEASE
LA English
DT Article
DE Insulin sensitivity; Metabolic syndrome; Nutrition
ID GROWTH-FACTOR 21; OXIDATIVE STRESS; NAFLD; STEATOSIS; SUPPLEMENTATION;
   POPULATION; METAANALYSIS; MECHANISMS; EXPRESSION; ADIPOKINES
AB Background: Non-alcoholic fatty liver disease is a major health problem worldwide. Resveratrol is a natural polyphenol found in edible plants that has a variety of biochemical and physiological effects. Aims: To evaluate the effect of resveratrol on insulin resistance, glucose and lipid metabolism in nonalcoholic fatty liver disease.
   Methods: Double-blind, randomized, placebo-controlled trial: 60 subjects with non-alcoholic fatty liver disease were given 2 placebo capsules (placebo group) or 2 150 mg resveratrol capsules (resveratrol group) twice daily for three months. Liver ultrasound imaging, anthropometric profile, serum liver enzymes, insulin, glucose, C-peptide, lipid profile, and inflammation-related cytokines were compared pre and post-treatment.
   Results: Compared with the placebo group, resveratrol significantly decreased aspartate aminotransferase, glucose and low-density lipoprotein cholesterol [-6.00 (-9.00, -3.00) IU/L, -0.64 +/- 0.31 mmol/L, and -0.41 +/- 0.35 mmol/L, respectively, P <= 0.001] alanine aminotransferase, total cholesterol [7.00 (-11.0, -2.50) IU/L and -0.67 +/- 0.50 mmol/L, respectively, P=0.002], and homeostasis model assessment insulin resistance index (-0.60 +/- 1.15, P=0.016). In the resveratrol group significant reductions of the levels of tumour necrosis factor-alpha, cytokeratin 18 fragment, and fibroblast growth factor 21 [0.53 +/- 1.30 pg/mL, 26.9 (70.3, 5.12) IU/L and 23.3 (43.0, 0.31) pg/mL, respectively, P < 0.05] and elevation of adiponectin level [1.22 (-0.37, 1.60) ng/mL, P=0.025] were observed.
   Conclusion: Resveratrol supplementation may benefit patients with non-alcoholic fatty liver disease. (C) 2014 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.
C1 [Chen, Shihui; Ran, Li; Wan, Jing; Qin, Yu; Shu, Furong; Gao, Yanxiang; Yuan, Lijia; Zhang, Qianyong; Mi, Mantian] Third Mil Med Univ, Chongqing Key Lab Nutr & Food Safety, Res Ctr Nutr & Food Safety, 30 Gaotanyan St, Chongqing 400038, Peoples R China.
   [Zhao, Xiaolan; Wang, Xiaofang] Third Mil Med Univ, Southwest Hosp, Hlth Care Ctr, Affiliated Hosp 1, Chongqing 400038, Peoples R China.
C3 Army Medical University; Army Medical University
RP Zhang, QY (corresponding author), Third Mil Med Univ, Chongqing Key Lab Nutr & Food Safety, Res Ctr Nutr & Food Safety, 30 Gaotanyan St, Chongqing 400038, Peoples R China.
EM zqianyong@sina.com; mimantian@hotmail.com
FU National Natural Science Foundation of China [30972469, 81273059];
   Science and Technology Key Project Foundation of Chongqing [CSTC,
   2011AB5040]; National Science-technology Support Plan Projects
   Foundation of China [2012BAI35B02]
FX This study was supported by the National Natural Science Foundation of
   China (No. 30972469; No. 81273059), the Science and Technology Key
   Project Foundation of Chongqing (No. CSTC, 2011AB5040), and the National
   Science-technology Support Plan Projects Foundation of China (No.
   2012BAI35B02).
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NR 41
TC 262
Z9 275
U1 4
U2 84
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1590-8658
EI 1878-3562
J9 DIGEST LIVER DIS
JI Dig. Liver Dis.
PD MAR
PY 2015
VL 47
IS 3
BP 226
EP 232
DI 10.1016/j.dld.2014.11.015
PG 7
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA CB9SL
UT WOS:000349972600009
PM 25577300
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Luo, Y
   Rana, P
   Will, Y
AF Luo, Yi
   Rana, Payal
   Will, Yvonne
TI Cyclosporine A and palmitic acid treatment synergistically induce
   cytotoxicity in HepG2 cells
SO TOXICOLOGY AND APPLIED PHARMACOLOGY
LA English
DT Article
DE Cyclosporine A; Organ transplantation; Immunosuppression; Free fatty
   acids; Metabolic syndrome; c-Jun N-terminal kinases
ID FREE FATTY-ACIDS; INDUCED LIVER-INJURY; N-TERMINAL KINASE; INDUCED
   HEPATOTOXICITY; RAT HEPATOCYTES; IN-VITRO; HEART-TRANSPLANTATION;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; HEPATITIS-C
AB Immunosuppressant cyclosporine A (CsA) treatment can cause severe side effects. Patients taking immunosuppressant after organ transplantation often display hyperlipidemia and obesity. Elevated levels of free fatty acids have been linked to the etiology of metabolic syndromes, nonalcoholic fatty liver and steatohepatitis. The contribution of free fatty acids to CsA-induced toxicity is not known. In this study we explored the effect of palmitic acid on CsA-induced toxicity in HepG2 cells. CsA by itself at therapeutic exposure levels did not induce detectible cytotoxicity in HepG2 cells. Co-treatment of palmitic acid and CsA resulted in a dose dependent increase in cytotoxicity, suggesting that fatty acid could sensitize cells to CsA-induced cytotoxicity at the therapeutic doses of CsA. A synergized induction of caspase-3/7 activity was also observed, indicating that apoptosis may contribute to the cytotoxicity. We demonstrated that CsA reduced cellular oxygen consumption which was further exacerbated by palmitic acid, implicating that impaired mitochondrial respiration might be an underlying mechanism for the enhanced toxicity. Inhibition of c-Jun N-terminal kinase (JNK) attenuated palmitic acid and CsA induced toxicity, suggesting that JNK activation plays an important role in mediating the enhanced palmitic acid/CsA-induced toxicity. Our data suggest that elevated FFA levels, especially saturated FFA such as palmitic acid, may be predisposing factors for CsA toxicity, and patients with underlying diseases that would elevate free fatty acids may be susceptible to CsA-induced toxicity. Furthermore, hyperlipidemia/obesity resulting from immunosuppressive therapy may aggravate CsA-induced toxicity and worsen the outcome in transplant patients. (C) 2012 Elsevier Inc. All rights reserved.
C1 [Luo, Yi] Pfizer Inc, Pfizer Global Res & Dev, Groton New London Labs, Compound Safety Predict Grp, Groton, CT 06340 USA.
C3 Pfizer; Pfizer USA
RP Luo, Y (corresponding author), Pfizer Inc, Pfizer Global Res & Dev, Groton New London Labs, Compound Safety Predict Grp, MS118W-118, Groton, CT 06340 USA.
EM yi.luo@pfizer.com
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NR 49
TC 15
Z9 17
U1 1
U2 43
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0041-008X
EI 1096-0333
J9 TOXICOL APPL PHARM
JI Toxicol. Appl. Pharmacol.
PD JUN 1
PY 2012
VL 261
IS 2
BP 172
EP 180
DI 10.1016/j.taap.2012.03.022
PG 9
WC Pharmacology & Pharmacy; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Toxicology
GA 951TY
UT WOS:000304744100006
PM 22521608
DA 2025-06-11
ER

PT J
AU Pérez-Pérez, R
   López, JA
   García-Santos, E
   Camafeita, E
   Gómez-Serrano, M
   Ortega-Delgado, FJ
   Ricart, W
   Fernández-Real, JM
   Peral, B
AF Perez-Perez, Rafael
   Lopez, Juan A.
   Garcia-Santos, Eva
   Camafeita, Emilio
   Gomez-Serrano, Maria
   Ortega-Delgado, Francisco J.
   Ricart, Wifredo
   Fernandez-Real, Jose M.
   Peral, Belen
TI Uncovering Suitable Reference Proteins for Expression Studies in Human
   Adipose Tissue with Relevance to Obesity
SO PLOS ONE
LA English
DT Article
ID ENDOPLASMIC-RETICULUM STRESS; TYPE-2 DIABETES-MELLITUS; GENE-EXPRESSION;
   HEPATOCELLULAR-CARCINOMA; INSULIN SENSITIVITY; METABOLIC SYNDROME; DJ-1;
   PROTEOMICS; DISEASE; MARKERS
AB Background: Protein expression studies based on the two major intra-abdominal human fat depots, the subcutaneous and the omental fat, can shed light into the mechanisms involved in obesity and its co-morbidities. Here we address, for the first time, the identification and validation of reference proteins for data standardization, which are essential for accurate comparison of protein levels in expression studies based on fat from obese and non-obese individuals.
   Methodology and Findings: To uncover adipose tissue proteins equally expressed either in omental and subcutaneous fat depots (study 1) or in omental fat from non-obese and obese individuals (study 2), we have reanalyzed our previously published data based on two-dimensional fluorescence difference gel electrophoresis. Twenty-four proteins (12 in study 1 and 12 in study 2) with similar expression levels in all conditions tested were selected and identified by mass spectrometry. Immunoblotting analysis was used to confirm in adipose tissue the expression pattern of the potential reference proteins and three proteins were validated: PARK7, ENOA and FAA. Western Blot analysis was also used to test customary loading control proteins. ENOA, PARK7 and the customary loading control protein Beta-actin showed steady expression profiles in fat from non-obese and obese individuals, whilst FAA maintained steady expression levels across paired omental and subcutaneous fat samples.
   Conclusions: ENOA, PARK7 and Beta-actin are proper reference standards in obesity studies based on omental fat, whilst FAA is the best loading control for the comparative analysis of omental and subcutaneous adipose tissues either in obese and non-obese subjects. Neither customary loading control proteins GAPDH and TBB5 nor CALX are adequate standards in differential expression studies on adipose tissue. The use of the proposed reference proteins will facilitate the adequate analysis of proteins differentially expressed in the context of obesity, an aim difficult to achieve before this study.
C1 [Perez-Perez, Rafael; Garcia-Santos, Eva; Gomez-Serrano, Maria; Peral, Belen] CSIC, Inst Invest Biomed, Madrid, Spain.
   [Perez-Perez, Rafael; Garcia-Santos, Eva; Gomez-Serrano, Maria; Peral, Belen] Univ Autonoma Madrid, Madrid, Spain.
   [Perez-Perez, Rafael; Garcia-Santos, Eva; Gomez-Serrano, Maria; Ortega-Delgado, Francisco J.; Ricart, Wifredo; Fernandez-Real, Jose M.; Peral, Belen] ISCIII, CIBER Fisiopatol Obesidad & Nutr CIBERob, Madrid, Spain.
   [Lopez, Juan A.; Camafeita, Emilio] CNIC, Unidad Prote, Madrid, Spain.
   [Ortega-Delgado, Francisco J.; Ricart, Wifredo; Fernandez-Real, Jose M.] Hosp Dr Josep Trueta, Dept Diabet Endocrinol & Nutr, Girona, Spain.
C3 Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Instituto
   de Investigaciones Biomedicas Alberto Sols (IIBM); Autonomous University
   of Madrid; Instituto de Salud Carlos III; CIBER - Centro de
   Investigacion Biomedica en Red; CIBEROBN; Centro Nacional de
   Investigaciones Cardiovasculares (CNIC); Universitat de Girona; Girona
   University Hospital Dr. Josep Trueta
RP Pérez-Pérez, R (corresponding author), CSIC, Inst Invest Biomed, Madrid, Spain.
EM bperal@iib.uam.es
RI Fernández-Real, Jose Manuel/AGH-3599-2022; Gómez-Serrano,
   María/AAZ-3953-2021; Lopez, Juan/JCD-9404-2023; Ortega, Francisco
   Jose/F-3883-2016; Lopez, Juan Antonio/G-7750-2015; PERAL,
   BELEN/F-4562-2015
OI Fernandez-Real, Jose Manuel/0000-0002-7442-9323; Ortega, Francisco
   Jose/0000-0003-2111-769X; Ricart, Wifredo/0000-0002-3452-9098; Lopez,
   Juan Antonio/0000-0002-9097-6060; Gomez-Serrano,
   Maria/0000-0002-9669-091X; PERAL, BELEN/0000-0003-4984-4020;
   Perez-Perez, Rafael/0000-0001-7726-5873
FU MICINN [SAF-2009-10461, SAF-2008-02073]; Fundacion Mutua Madrilena,
   Spain; Pro CNIC Foundation
FX This work was supported by Grants SAF-2009-10461 and SAF-2008-02073 from
   the MICINN, and from the Fundacion Mutua Madrilena, Spain (BP). The CNIC
   is supported by MICINN and Pro CNIC Foundation. CIBERobn is an
   initiative from the Instituto de Salud Carlos III. The funders had no
   role in study design, data collection nor analysis, decision to publish,
   or preparation of the manuscript.
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NR 38
TC 21
Z9 23
U1 0
U2 7
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JAN 17
PY 2012
VL 7
IS 1
AR e30326
DI 10.1371/journal.pone.0030326
PG 9
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 907XU
UT WOS:000301454400114
PM 22272336
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Lipinski, B
   Pretorius, E
AF Lipinski, Boguslaw
   Pretorius, Etheresia
TI Novel pathway of iron-induced blood coagulation: implications for
   diabetes mellitus and its complications
SO POLSKIE ARCHIWUM MEDYCYNY WEWNETRZNEJ-POLISH ARCHIVES OF INTERNAL
   MEDICINE
LA English
DT Review
DE diabetes; fibrinogen; hydroxyl radicals; iron; polyphenols
ID OXIDATIVE STRESS; ERYTHROCYTE SEDIMENTATION; GLYCEMIC CONTROL; LABILE
   IRON; LIPOIC ACID; IN-VITRO; FIBRIN; DISEASE; INSULIN; HEME
AB Fibrinogen (FBG) is a high-molecular-weight protein and precursor to the enzymatically formed fibrin. It has been recently discovered that FBG can be converted into an insoluble, fibrin-like polymer by a nonenzymatic action of hydroxyl radicals (HRs). These free radicals are generated due to the reaction between hydroxyl groups of water and trivalent ferric ions without the participation of any redox agent. The inter-action between HRs and FBG occurs in a purified system, as well as in human plasma and in whole blood. Scanning electron microscopy (SEM) of thrombin-induced fibers and those generated with ferric chloride has shown substantial differences in their morphology and susceptibility to enzymatic degradation. Fibrin strands caused by thrombin are thick and easily digested with chymotrypsin. By contrast, the dense matted deposits formed from FBG in the presence of ferric ions are remarkably resistant to proteolytic and chemical degradations due to the presence of inter-molecular hydrophobic bonds. Thus, we postulate that this iron-catalyzed reaction represents a novel blood coagulation pathway operating in degenerative diseases. By means of SEM, we showed the presence of dense fibrin-like deposits in the blood of diabetic patients. Therefore, the prothrombotic state and cardiovascular complications observed in diabetes can be explained in terms of the persistent in vivo action of free iron. This phenomenon may explain hemorheologic disturbances in patients with metabolic syndrome and other diseases caused by iron overload. Of note, HRs can be effectively scavenged by phenolic substances; therefore, certain natural polyphenolic substances, which also scavenge HRs, may be considered to have a potential antidiabetic effect. Moreover, natural or synthetic iron-binding substances may also be considered as a new class of antidiabetic drugs.
C1 [Lipinski, Boguslaw] Harvard Univ, Sch Med, Joslin Diabet Ctr, Boston, MA 02215 USA.
   [Pretorius, Etheresia] Univ Pretoria, Fac Hlth Sci, Dept Physiol, Arcadia, South Africa.
C3 Harvard University; Harvard University Medical Affiliates; Joslin
   Diabetes Center, Inc.; Harvard Medical School; University of Pretoria
RP Lipinski, B (corresponding author), Harvard Univ, Sch Med, Joslin Diabet Ctr, 1 Joslin Pl, Boston, MA 02215 USA.
EM b.lipinski2006@rcn.com
RI Pretorius, Etheresia/P-2978-2016
OI Pretorius, Etheresia/0000-0002-9108-2384
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NR 69
TC 75
Z9 80
U1 0
U2 13
PU MEDYCYNA PRAKTYCZNA SP K SP ZOO
PI KRAKOW
PA REJTANA 2, KRAKOW, 30-510    AP, POLAND
SN 0032-3772
J9 POL ARCH MED WEWN
JI Pol. Arch. Med. Wewn.
PY 2012
VL 122
IS 3
BP 115
EP 122
DI 10.20452/pamw.1201
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 922HG
UT WOS:000302537400006
PM 22460041
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Schmid, J
   Ludwig, B
   Schally, AV
   Steffen, A
   Ziegler, CG
   Block, NL
   Koutmani, Y
   Brendel, MD
   Karalis, KP
   Simeonovic, CJ
   Licinio, J
   Ehrhart-Bornstein, M
   Bornstein, SR
AF Schmid, Janine
   Ludwig, Barbara
   Schally, Andrew V.
   Steffen, Anja
   Ziegler, Christian G.
   Block, Norman L.
   Koutmani, Yassemi
   Brendel, Mathias D.
   Karalis, Katia P.
   Simeonovic, Charmaine J.
   Licinio, Julio
   Ehrhart-Bornstein, Monika
   Bornstein, Stefan R.
TI Modulation of pancreatic islets-stress axis by hypothalamic releasing
   hormones and 11β-hydroxysteroid dehydrogenase
SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF
   AMERICA
LA English
DT Article
DE islet proliferation; regenerative therapy; metabolic syndrome
ID BETA-CELLS; DIABETES-MELLITUS; INSULIN-RELEASE; CA2+ INFLUX; RECEPTOR;
   TYPE-1; RAT; IDENTIFICATION; PROLIFERATION; INHIBITION
AB Corticotropin-releasing hormone (CRH) and growth hormone-releasing hormone (GHRH), primarily characterized as neuroregulators of the hypothalamic-pituitary-adrenal axis, directly influence tissue-specific receptor-systems for CRH and GHRH in the endocrine pancreas. Here, we demonstrate the expression of mRNA for CRH and CRH-receptor type 1 (CRHR1) and of protein for CRHR1 in rat and human pancreatic islets and rat insulinoma cells. Activation of CRHR1 and GHRH-receptor significantly increased cell proliferation and reduced cell apoptosis. CRH stimulated both cellular content and release of insulin in rat islet and insulinoma cells. At the ultrastructural level, CRHR1 stimulation revealed a more active metabolic state with enlarged mitochondria. Moreover, glucocorticoids that promote glucose production are balanced by both 11b-hydroxysteroid dehydrogenase (11 beta-HSD) isoforms; 11 beta-HSD-type-1 and 11 beta-HSD-type-2. We demonstrated expression of mRNA for 11 beta-HSD-1 and 11 beta-HSD-2 and protein for 11 beta-HSD-1 in rat and human pancreatic islets and insulinoma cells. Quantitative real-time PCR revealed that stimulation of CRHR1 and GHRH-receptor affects the metabolism of insulinoma cells by down-regulating 11 beta-HSD-1 and up-regulating 11 beta-HSD-2. The 11 beta-HSD enzyme activity was analyzed by measuring the production of cortisol from cortisone. Similarly, activation of CRHR1 resulted in reduced cortisol levels, indicating either decreased 11 beta-HSD-1 enzyme activity or increased 11 beta-HSD-2 enzyme activity; thus, activation of CRHR1 alters the glucocorticoid balance toward the inactive form. These data indicate that functional receptor systems for hypothalamic-releasing hormone agonists exist within the endocrine pancreas and influence synthesis of insulin and the pancreatic glucocorticoid shuttle. Agonists of CRHR1 and GHRH-receptor, therefore, may play an important role as novel therapeutic tools in the treatment of diabetes mellitus.
C1 [Schally, Andrew V.; Block, Norman L.] Univ Miami, Miller Sch Med, Dept Pathol, Div Endocrinol, Miami, FL 33136 USA.
   [Schally, Andrew V.; Block, Norman L.] Univ Miami, Miller Sch Med, Dept Pathol, Div Hematol Oncol, Miami, FL 33136 USA.
   [Schally, Andrew V.; Block, Norman L.] Univ Miami, Miller Sch Med, Dept Med, Div Endocrinol, Miami, FL 33136 USA.
   [Schally, Andrew V.; Block, Norman L.] Univ Miami, Miller Sch Med, Dept Med, Div Hematol Oncol, Miami, FL 33136 USA.
   [Schmid, Janine; Ludwig, Barbara; Steffen, Anja; Ziegler, Christian G.; Brendel, Mathias D.; Ehrhart-Bornstein, Monika; Bornstein, Stefan R.] Univ Hosp Carl Gustav Carus, Dept Med 3, D-01307 Dresden, Germany.
   [Ludwig, Barbara; Brendel, Mathias D.] Paul Langerhans Inst, D-01307 Dresden, Germany.
   [Ludwig, Barbara; Ehrhart-Bornstein, Monika; Bornstein, Stefan R.] Tech Univ Dresden, Ctr Regenerat Therapies Dresden, D-01307 Dresden, Germany.
   [Schally, Andrew V.; Block, Norman L.] Vet Adm Med Ctr, Miami, FL 33125 USA.
   [Koutmani, Yassemi; Karalis, Katia P.] Acad Athens, Biomed Res Fdn, Ctr Basic Res, Dev Biol Sect, Athens 11527, Greece.
   [Karalis, Katia P.] Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Div Endocrinol,Childrens Hosp, Boston, MA 02115 USA.
   [Simeonovic, Charmaine J.; Licinio, Julio] Australian Natl Univ, John Curtin Sch Med Res, Dept Immunol, Canberra, ACT 2601, Australia.
C3 University of Miami; University of Miami; University of Miami;
   University of Miami; Technische Universitat Dresden; Carl Gustav Carus
   University Hospital; Technische Universitat Dresden; Technische
   Universitat Dresden; US Department of Veterans Affairs; Veterans Health
   Administration (VHA); Academy of Athens; Harvard University; Harvard
   Medical School; Harvard University Medical Affiliates; Beth Israel
   Deaconess Medical Center; Boston Children's Hospital; Australian
   National University; John Curtin School of Medical Research
RP Schally, AV (corresponding author), Univ Miami, Miller Sch Med, Dept Pathol, Div Endocrinol, Miami, FL 33136 USA.
EM andrew.schally@va.gov; Stefan.Bornstein@uniklinikum-dresden.de
RI Koutmani, Yassemi/AAD-1475-2021; Simeonovic, Charmaine/AAG-9945-2020;
   Olagunju, Temitayo/MXL-1626-2025; Licinio, Julio/L-4244-2013
OI Licinio, Julio/0000-0001-6905-5884; Simeonovic,
   Charmaine/0000-0002-7161-5825; Schally, Andrew/0000-0003-1273-6747
FU Deutsche Forschungsgemeinschaft [KFO 252/1, BR1179/4-1]; German Federal
   Ministry of Education and Research [AUS 10/802]; Deutsche
   Forschungsgemeinschaft Center for Regenerative Therapies Dresden Cluster
   of Excellence
FX We thank Linda Gebauer for her technical help, Silke Zeugner for her
   assistance with immunohistochemistry, Doreen Streichert for help with
   electron microscopy, and Martina Haberland for help in preparation of
   the manuscript. This work was supported by Grants KFO 252/1 and
   BR1179/4-1 of the Deutsche Forschungsgemeinschaft (to M.D.B., S.R.B.,
   and B.L.); by a grant of the German Federal Ministry of Education and
   Research to the German Center for Diabetes Research (to S.R.B.and B.L.);
   by the Deutsche Forschungsgemeinschaft Center for Regenerative Therapies
   Dresden Cluster of Excellence (S.R.B., B.L., and M.D.B.); and by a grant
   of the German Federal Ministry of Education and Research AUS 10/802 (to
   S.R.B.).
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NR 32
TC 38
Z9 42
U1 0
U2 10
PU NATL ACAD SCIENCES
PI WASHINGTON
PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA
SN 0027-8424
J9 P NATL ACAD SCI USA
JI Proc. Natl. Acad. Sci. U. S. A.
PD AUG 16
PY 2011
VL 108
IS 33
BP 13722
EP 13727
DI 10.1073/pnas.1110965108
PG 6
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 807KC
UT WOS:000293895100072
PM 21825133
OA Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Bidwell, AJ
   Holmstrup, ME
   Doyle, RP
   Fairchild, TJ
AF Bidwell, A. J.
   Holmstrup, M. E.
   Doyle, R. P.
   Fairchild, T. J.
TI Assessment of endothelial function and blood metabolite status following
   acute ingestion of a fructose-containing beverage
SO ACTA PHYSIOLOGICA
LA English
DT Article
DE endothelial function; fructose; nitric oxide; reactive hyperaemia; uric
   acid
ID URIC-ACID; DIETARY FRUCTOSE; CORN SYRUP; CONSUMPTION; HYPERURICEMIA;
   HOMEOSTASIS; HYPOTHESIS; RESISTANCE; EPIDEMIC; STRESS
AB Aim:
   Fructose intake has increased concurrent with sugar intake and this increase has been implicated in contributing to the development of metabolic syndrome risk factors. Recent evidence suggests a role for uric acid (UA) as a potential mediator via suppression of nitric oxide (NO) bioavailability. The aim of this study was to explore this hypothesis by measuring changes in UA concentration and systemic NO bioavailability as well as endothelial function in response to acute ingestion of a glucose-fructose beverage.
   Methods:
   Ten young (26.80 +/- 4.80 years), non-obese (body mass index: 25.1 +/- 2.55 kg m-2; percent body fat: 13.5 +/- 6.9%) male subjects ingested either a glucose (100 g dextrose in 300 mL) or isocaloric glucose-fructose (glucose : fructose; 45 : 55 g in 300 mL) beverage. Blood was sampled pre- and every 15-min post-ingestion per 90 min and assayed for glucose, lactate, fructose, total nitrate/nitrate, UA and blood lipids. Forearm blood flow and pulse-wave velocity were recorded prior to and at 30 and 45 min time intervals post-ingestion, respectively, while heart rate, systolic and diastolic blood pressure were recorded every 15 min.
   Results:
   The glucose-fructose ingestion was associated with a significant (P < 0.05) increase in plasma lactate concentration and altered free fatty acid levels when compared with glucose-only ingestion. However, UA was not significantly different (P = 0.08) between conditions (AUC: -1018 +/- 1675 vs. 2171 +/- 1270 mu mol L-1 per 90 min for glucose and glucose-fructose conditions respectively). Consequently, no significant (P < 0.05) difference in endothelial function or systemic NO bioavailability was observed.
   Conclusion:
   Acute consumption of a fructose-containing beverage was not associated with significantly altered UA concentration, endothelial function or systemic NO bioavailability.
C1 [Fairchild, T. J.] Murdoch Univ, Integrated Hlth Inst, Murdoch, WA 6150, Australia.
   [Bidwell, A. J.; Holmstrup, M. E.; Fairchild, T. J.] Syracuse Univ, Dept Exercise Sci, Syracuse, NY USA.
   [Doyle, R. P.] Syracuse Univ, Dept Chem, Syracuse, NY 13244 USA.
C3 Murdoch University; Syracuse University; Syracuse University
RP Fairchild, TJ (corresponding author), Murdoch Univ, Integrated Hlth Inst, Rm 1-015,90 S St, Murdoch, WA 6150, Australia.
EM t.fairchild@murdoch.edu.au
RI Fairchild, Timothy/A-1999-2012; Doyle, Robert/W-1921-2018
OI Fairchild, Timothy/0000-0002-3975-2213
FU Syracuse University Gerontology Center; Gatorade
FX This research was supported through funding by the Syracuse University
   Gerontology Center and Gatorade.
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NR 35
TC 9
Z9 13
U1 0
U2 11
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1748-1708
EI 1748-1716
J9 ACTA PHYSIOL
JI Acta Physiol.
PD SEP
PY 2010
VL 200
IS 1
BP 35
EP 43
DI 10.1111/j.1748-1716.2010.02106.x
PG 9
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA 635AS
UT WOS:000280628600005
PM 20331537
DA 2025-06-11
ER

PT J
AU Ghorbani, Z
   Shoaibinobarian, N
   Noormohammadi, M
   Taylor, K
   Kazemi, A
   Bonyad, A
   Khoshdooz, S
   Löber, U
   Forslund-Startceva, SK
AF Ghorbani, Zeinab
   Shoaibinobarian, Nargeskhatoon
   Noormohammadi, Morvarid
   Taylor, Kate
   Kazemi, Asma
   Bonyad, Ali
   Khoshdooz, Sara
   Loeber, Ulrike
   Forslund-Startceva, Sofia K.
TI Reinforcing gut integrity: A systematic review and meta-analysis of
   clinical trials assessing probiotics, synbiotics, and prebiotics on
   intestinal permeability markers
SO PHARMACOLOGICAL RESEARCH
LA English
DT Review
DE Gut barrier integrity; Probiotic bacteria; Synbiotic; Prebiotic
ID INSULIN-RESISTANCE; INULIN SUPPLEMENTATION; ANTIOXIDANT STATUS;
   METABOLIC SYNDROME; OXIDATIVE STRESS; DOUBLE-BLIND; WOMEN; INFLAMMATION;
   MICROBIOTA; DIET
AB Background: Given the magnitude and variety of chronic metabolic disease linked to increased intestinal permeability, appropriate strategies to reinforce gut barrier function are urgently needed. Methods: This systematic review and meta-analysis explores the effects of pro- and synbiotic, or prebiotic administration, on various intestinal permeability markers. Systematic searches across the Medline and Scopus databases were performed from 1961 to January 2023. The review included data from 46 published studies on pro- and synbiotics, and 22 studies on prebiotics. 46 The meta-analysis calculated standardized mean differences (SMD) along with 95 % confidence intervals (95 %CIs) using a random-effects model to evaluate the average effect sizes (ES). To analyze heterogeneity, we employed Galbraith plots and performed the Cochrane Chi-squared test. Results: The analysis on 24 trials (28 ES, n = 1603) revealed a significant reduction in lipopolysaccharide levels following pro- and synbiotics consumption with high heterogeneity and very low certainty of evidence (SMD (95 %CI) = -0.54 (-1.01, -0.07); I-2 (%) = 94.4). Synthesis of 13 trials showed zonulin levels were significantly lowered after pro- and synbiotics consumption with high heterogeneity and moderate certainty of evidence (15 ES, n=778) (SMD (95 %CI) = -0.49 (-0.79, -0.18); I-2 (%) = 74.9). Following prebiotics supplementation, a significant reduction in lipopolysaccharide levels was observed, with high heterogeneity identified from data including 16 RCTs (n = 792; SMD (95 %CI) = -0.88 (-1.28, -0.47); P < 0.001; high certainty of evidence; I-2 (%) = 85.7; P-heterogeneity< 0.001). Conclusion: This meta-analysis revealed promising findings regarding the efficacy of pro- and synbiotic and prebiotic supplements in alleviating "leaky gut".
C1 [Ghorbani, Zeinab; Noormohammadi, Morvarid; Bonyad, Ali; Khoshdooz, Sara] Guilan Univ Med Sci, Heshmat Hosp, Cardiovasc Dis Res Ctr, Sch Med,Dept Cardiol, 15 Khordad St,Dist 2, Rasht, Iran.
   [Ghorbani, Zeinab; Shoaibinobarian, Nargeskhatoon] Guilan Univ Med Sci, Sch Med, Dept Clin Nutr, Rasht, Iran.
   [Shoaibinobarian, Nargeskhatoon] Islamic Azad Univ, Sch Med Sci & Technol, Dept Nutr, Sci & Res Branch, Tehran, Iran.
   [Noormohammadi, Morvarid] Iran Univ Med Sci, Sch Publ Hlth, Dept Nutr, Tehran, Iran.
   [Taylor, Kate] Univ Exeter, Fac Hlth & Life Sci, Exeter, England.
   [Kazemi, Asma] Shiraz Univ Med Sci, Nutr Res Ctr, Sch Nutr & Food Sci, Shiraz, Iran.
   [Loeber, Ulrike; Forslund-Startceva, Sofia K.] Max Delbruck Ctr Mol Med Helmholtz Assoc, D-13125 Berlin, Germany.
   [Loeber, Ulrike; Forslund-Startceva, Sofia K.] Charite Univ Med Berlin, Expt & Clin Res Ctr, Lindenberger Weg 80, D-13125 Berlin, Germany.
   [Loeber, Ulrike; Forslund-Startceva, Sofia K.] Max Delbruck Ctr Mol Med, Lindenberger Weg 80, D-13125 Berlin, Germany.
   [Loeber, Ulrike; Forslund-Startceva, Sofia K.] Charite Univ Med Berlin, D-10117 Berlin, Germany.
   [Loeber, Ulrike; Forslund-Startceva, Sofia K.] Free Univ Berlin, D-10117 Berlin, Germany.
   [Loeber, Ulrike; Forslund-Startceva, Sofia K.] Humboldt Univ, D-10117 Berlin, Germany.
   [Loeber, Ulrike; Forslund-Startceva, Sofia K.] Berlin Inst Hlth, D-10117 Berlin, Germany.
   [Loeber, Ulrike; Forslund-Startceva, Sofia K.] DZHK German Ctr Cardiovasc Res, Partner Site, Berlin, Germany.
   [Forslund-Startceva, Sofia K.] Struct & Computat Biol Unit, Struct & Computat Biol Unit, European Mol Biol Lab, D-69117 Heidelberg, Germany.
C3 Guilan University of Medical Sciences; Guilan University of Medical
   Sciences; Islamic Azad University; Iran University of Medical Sciences;
   University of Exeter; Shiraz University of Medical Science; Helmholtz
   Association; Max Delbruck Center for Molecular Medicine; Berlin
   Institute of Health; Free University of Berlin; Humboldt University of
   Berlin; Charite Universitatsmedizin Berlin; Helmholtz Association; Max
   Delbruck Center for Molecular Medicine; Berlin Institute of Health; Free
   University of Berlin; Humboldt University of Berlin; Charite
   Universitatsmedizin Berlin; Free University of Berlin; Humboldt
   University of Berlin; Berlin Institute of Health; German Centre for
   Cardiovascular Research; European Molecular Biology Laboratory (EMBL)
RP Ghorbani, Z (corresponding author), Guilan Univ Med Sci, Heshmat Hosp, Cardiovasc Dis Res Ctr, Sch Med,Dept Cardiol, 15 Khordad St,Dist 2, Rasht, Iran.; Forslund-Startceva, SK (corresponding author), Max Delbruck Centrum Mol Med Helmholtz Gemeinschaf, MDC Berlin Buch, Robert Rossle Str 10, D-13125 Berlin, Germany.
EM z.ghorbani.h@gmail.com; Sofia.Forslund@mdc-berlin.de
RI Löber, Ulrike/AEB-2349-2022; ghorbani, zeinab/AAF-5343-2021; Kazemi,
   Asma/AAV-4769-2021; Forslund, Sofia/Y-2393-2019
FU EU [101095540]; BMBF [01EK2103A, SFB1449 ("HYDROGEL"), SFB1470]
FX SKF received funding from EU Horizon grant 101095540 ("IMME-DIATE") ,
   BMBF project 01EK2103A ("PROSPER") , DFG networks SFB1449 ("HYDROGEL")
   and SFB1470 ("HFpEF") .
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NR 111
TC 0
Z9 0
U1 1
U2 1
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 1043-6618
EI 1096-1186
J9 PHARMACOL RES
JI Pharmacol. Res.
PD JUN
PY 2025
VL 216
AR 107780
DI 10.1016/j.phrs.2025.107780
PG 26
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 3FI0C
UT WOS:001498981500002
PM 40378939
OA hybrid
DA 2025-06-11
ER

PT J
AU Kim, MH
   Lee, YJ
   Linton, JA
   Song, YHY
   Lee, JW
AF Kim, Min-Hyo
   Lee, Yaeji
   Linton, John Alderman
   Song, Youhyun
   Lee, Ji-Won
TI Comparison of Metabolic Risk Factors Based on the Type of Physical
   Activity in Korean Adolescents: Results from a Nationwide
   Population-Based Survey
SO KOREAN JOURNAL OF FAMILY MEDICINE
LA English
DT Article
DE Adolescent; Aerobic Exercise; Resistance Exercise; Exercise;
   Cardiovascular Risk Factors
ID CARDIORESPIRATORY FITNESS; RESISTANCE EXERCISE; OXIDATIVE STRESS;
   AEROBIC EXERCISE; PREVALENCE; CHILDREN; OVERWEIGHT; HEALTH
AB Background: Physical activity (PA) is associated with a favorable metabolic risk profile in adults. However, its role in adolescents remains unclear. In this study, using data (2019-2021) from the 8th Korea National Health and Nutrition Examination Survey, we investigated the optimal exercise type for preventing metabolic complications in adolescents. Methods: A total of 1,222 eligible adolescent participants (12-18 -year -old) were divided into four groups as follows: aerobic exercise (AE), resistance exercise (RE), combined aerobic and resistance exercise (CE), and no exercise (NE). Daily PA was assessed using the international PA questionnaire. Blood samples were collected to measure lipid, glucose, and insulin levels. Additionally, the homeostasis model assessment for insulin resistance (HOMA-IR) and triglyceride-glucose (TyG) indices were measured. Multivariate regression analysis was used to compare the metabolic risk factors across the PA groups before and after propensity score matching (PSM) adjustment for confounding variables. Results: The CE group exhibited improved fasting glucose levels, lower TyG index, reduced white blood cell count, and higher high -density lipoprotein (HDL) cholesterol levels than the NE group. The RE group exhibited lower mean blood pressure, triglyceride, fasting insulin, HOMA-IR, TyG index and a reduced risk of metabolic syndrome than the NE group. The AE group had higher total and HDL cholesterol levels. In detailed comparison of the AE and RE groups, the RE group consistently exhibited favorable metabolic parameters, including lower blood pressure and total and low -density cholesterol levels, which persisted after PSM. Conclusion: These findings highlight the positive effects of PA on cardiovascular risk factors in adolescents. Thus, RE may have a more favorable metabolic effect than AE. Further studies are needed to validate the benefits of exercise according to the exercise type.
C1 [Kim, Min-Hyo; Linton, John Alderman; Lee, Ji-Won] Yonsei Univ, Coll Med, Severance Hosp, Dept Family Med, Seoul, South Korea.
   [Lee, Yaeji] Yonsei Univ, Dept Biostat & Comp, Seoul, South Korea.
   [Linton, John Alderman] Yonsei Univ Hlth Syst, Severance Hosp, Int Hlth Care Ctr, Seoul, South Korea.
   [Song, Youhyun] Yonsei Univ, Gangnam Severance Hosp, Coll Med, Healthcare Res Team,Hlth Promot Ctr, Seoul, South Korea.
   [Lee, Ji-Won] Yonsei Univ, Inst Innovat Digital Healthcare, Seoul, South Korea.
C3 Yonsei University; Yonsei University Health System; Yonsei University;
   Yonsei University; Yonsei University Health System; Yonsei University;
   Yonsei University Health System; Yonsei University
RP Lee, JW (corresponding author), Yonsei Univ, Coll Med, Severance Hosp, Dept Family Med, Seoul, South Korea.; Song, YHY (corresponding author), Yonsei Univ, Gangnam Severance Hosp, Coll Med, Healthcare Res Team,Hlth Promot Ctr, Seoul, South Korea.; Lee, JW (corresponding author), Yonsei Univ, Inst Innovat Digital Healthcare, Seoul, South Korea.
EM WLGMEO_O@yuhs.ac; indi5645@yuhs.ac
RI LEE, Ji/C-2295-2009; Song, Youhyun/AAF-9491-2019
OI Lee, Yaeji/0000-0002-1411-1938; Song, Youhyun/0000-0001-5621-2107; LEE,
   JI WON/0000-0002-2666-4249; Linton, John/0000-0001-8000-3049
FU dustrial Technology (KEIT) - Korean government's Ministry of Trade,
   Industry, and Energy (MOTIE) [20018384]
FX This study received support from a Korea Evaluation Institute of
   Industrial Technology (KEIT) grant funded by the Korean government's
   Ministry of Trade, Industry, and Energy (MOTIE) (grant no., 20018384)
   awarded to the author (J.W.L.). It's important to emphasize that the
   funding source not been involved in shaping the study design, data
   collection, analysis, decisions regarding publication, or preparation of
   the manuscript.r dustrial Technology (KEIT) grant funded by the Korean
   government's Ministry of Trade, Industry, and Energy (MOTIE) (grant no.,
   20018384) awarded to the author (J.W.L.) . It's important to emphasize
   that the <B>FUNDING</B> source not been involved in shaping the study
   design, data collection, analysis, decisions regarding publication, or
   preparation of the manuscript.
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NR 28
TC 1
Z9 1
U1 0
U2 0
PU KOREAN ACAD FAMILY MEDICINE
PI SEOUL
PA GWANGHWAMUN OFFICIA 2003, SINMUNNO 1-GA, JONGNO-GU, SEOUL, 110-999,
   SOUTH KOREA
SN 2092-6715
J9 KOREAN J FAM MED
JI Korean J. Fam. Med.
PD MAY
PY 2024
VL 45
IS 3
BP 164
EP 175
DI 10.4082/kjfm.23.0164
PG 12
WC Primary Health Care
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA TN6P4
UT WOS:001241984600007
PM 38263901
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Apaza, CJ
   Días, M
   Tejedor, AG
   Boscá, L
   Llopis, JML
AF Apaza, Cesar Jeri
   Dias, Marisol
   Tejedor, Aurora Garcia
   Bosca, Lisardo
   Llopis, Jose Moises Laparra
TI Contribution of Nucleotide-Binding Oligomerization Domain-like (NOD)
   Receptors to the Immune and Metabolic Health
SO BIOMEDICINES
LA English
DT Review
DE NOD1/2; Toll-like receptors; immunonutrition; innate immunity; cancer
ID ENDOPLASMIC-RETICULUM STRESS; TOLL-LIKE RECEPTORS; INNATE IMMUNITY;
   LYSOPHOSPHATIDYLCHOLINE INDUCE; EICOSAPENTAENOIC ACID; OXIDIZED LIPIDS;
   GUT MICROBIOTA; ADIPOSE-TISSUE; FATTY-ACIDS; CELLS
AB Nucleotide-binding oligomerization domain-like (NOD) receptors rely on the interface between immunity and metabolism. Dietary factors constitute critical players in the activation of innate immunity and modulation of the gut microbiota. The latter have been involved in worsening or improving the control and promotion of diseases such as obesity, type 2 diabetes, metabolic syndrome, diseases known as non-communicable metabolic diseases (NCDs), and the risk of developing cancer. Intracellular NODs play key coordinated actions with innate immune 'Toll-like' receptors leading to a diverse array of gene expressions that initiate inflammatory and immune responses. There has been an improvement in the understanding of the molecular and genetic implications of these receptors in, among others, such aspects as resting energy expenditure, insulin resistance, and cell proliferation. Genetic factors and polymorphisms of the receptors are determinants of the risk and severity of NCDs and cancer, and it is conceivable that dietary factors may have significant differential consequences depending on them. Host factors are difficult to influence, while environmental factors are predominant and approachable with a preventive and/or therapeutic intention in obesity, T2D, and cancer. However, beyond the recognition of the activation of NODs by peptidoglycan as its prototypical agonist, the underlying molecular response(s) and its consequences on these diseases remain ill-defined. Metabolic (re)programming is a hallmark of NCDs and cancer in which nutritional strategies might play a key role in preventing the unprecedented expansion of these diseases. A better understanding of the participation and effects of immunonutritional dietary ingredients can boost integrative knowledge fostering interdisciplinary science between nutritional precision and personalized medicine against cancer. This review summarizes the current evidence concerning the relationship(s) and consequences of NODs on immune and metabolic health.
C1 [Apaza, Cesar Jeri; Llopis, Jose Moises Laparra] Madrid Inst Adv Studies Food IMDEA Food, Mol Immunonutrit Grp, Ctra Cantoblanco 8, Madrid 28049, Spain.
   [Dias, Marisol] Univ Minho, Ctr Biol Enginneering CEB, Iberian Nantotechnol Lab INL, P-4715330 Braga, Portugal.
   [Tejedor, Aurora Garcia] Univ Int Valencia VIU, Fac Hlth Sci, Bioact & Nutr Immunol Grp BIOINUT, Pintor Sorolla 21, Valencia 46002, Spain.
   [Bosca, Lisardo] Inst Invest Biomed Alberto Sols CSIC UAM, Arturo Duperier 4, Madrid 28029, Spain.
   [Bosca, Lisardo] Ctr Invest Biomed Red Enfermedades Cardiovasc CIBE, Melchor Fernandez Almagro 6, Madrid 28029, Spain.
C3 IMDEA Food Institute; Universidade do Minho; Universidad Internacional
   de Valencia VIU; Consejo Superior de Investigaciones Cientificas (CSIC);
   CSIC - Instituto de Investigaciones Biomedicas Alberto Sols (IIBM);
   CIBER - Centro de Investigacion Biomedica en Red; CIBERCV
RP Llopis, JML (corresponding author), Madrid Inst Adv Studies Food IMDEA Food, Mol Immunonutrit Grp, Ctra Cantoblanco 8, Madrid 28049, Spain.
EM immuno.cesar@imdea.org; marisol.dias@inl.int;
   agarciate@universidadviu.com; lbosca@iib.uam.es;
   moises.laparra@imdea.org
RI Tejedor, Aurora/AAB-6121-2019; Bosca, Lisardo/A-2059-2008; Laparra
   Llopis, Jose Moises/M-2882-2015
OI Garcia Tejedor, Aurora/0000-0002-9790-0659; Bosca,
   Lisardo/0000-0002-0253-5469; Laparra Llopis, Jose
   Moises/0000-0002-9378-2552; Gouveia Dias, Marisol/0000-0002-1758-1441
FU Food4ImNut
FX No Statement Available
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NR 94
TC 0
Z9 0
U1 0
U2 4
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2227-9059
J9 BIOMEDICINES
JI Biomedicines
PD FEB
PY 2024
VL 12
IS 2
AR 341
DI 10.3390/biomedicines12020341
PG 13
WC Biochemistry & Molecular Biology; Medicine, Research & Experimental;
   Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Research & Experimental Medicine;
   Pharmacology & Pharmacy
GA JD4X0
UT WOS:001171219400001
PM 38397943
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Abbas, NAT
   Fayed, FA
   El Sebaey, RS
   Hassan, HA
AF Abbas, Noha A. T.
   Fayed, Fawkia A.
   El Sebaey, Rabab Saber
   Hassan, Heba A.
TI Telmisartan and candesartan promote browning of white adipose tissue and
   reverse fatty liver changes in high fat diet fed male albino rats
SO NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
LA English
DT Article
DE HFD-induced NAFLD; Obesity; Telmisartan; Candesartan
ID ACTIVATED PROTEIN-KINASE; METABOLIC SYNDROME; SERUM TRIGLYCERIDES;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; ANGIOTENSIN; OBESITY; ENZYME;
   EXPRESSION; BDNF
AB Obesity is a key risk factor for many diseases, as cardiovascular disorders, diabetes, infertility, osteoarthritis, sleep apnea, non-alcoholic fatty liver disease (NAFLD) as well as increased risk for many cancers. Telmisartan and Candesartan cilexetil are angiotensin II receptor blockers which had proven to involve in pathogenesis of obesity and NAFLD. Aims: This work is designed to explore the possible mitigated effects of Telmisartan and Candesartan cilexetil on weight gain and fatty liver in high fat diet (HFD) fed rats. Main methods: The HFD rat model was achieved with induction of NAFLD. For Seven weeks either telmisartan or candesartan were orally administered at doses of 5 and 10 mg/kg respectively once daily. The effects of both drugs were evaluated by measurements of rat's body weight, food intakes, length, body mass index (BMI), liver weight, inguinal and interscapular fat weights. In addition, we assayed lipid profile, liver functions tests, serum inflammatory cytokines, adipokine and leptin. Lastly, liver and adipose tissue histopathological structures were evaluated. Key findings: at end of experiment, telmisartan and candesartan were highly effective in decreasing rat's body weight from (213.1 +/- 2.68 to 191.2 +/- 2.54 and 203.5 +/- 5.89 gm , respectively), BMI, liver weight, fat weights in addition reduced serum levels of lipid and liver enzymes. Also, inflammatory cytokines were reduced with repaired histopathological insults in liver by significantly damped NAFLD score from (6.5 +/- 0.17 to 1 +/- 0 and 4 +/- 0, respectively) and decreased areas of adipocytes from (21239.12 to 5355.7 and 11607.1 um2 , respectively).Significance: Telmisartan and candesartan have therapeutic potential against obesity and NAFLD induced by HFD in rats. All the previous indices showed more improvement in telmisartan than candesartan group.
C1 [Abbas, Noha A. T.; Fayed, Fawkia A.; El Sebaey, Rabab Saber; Hassan, Heba A.] Zagazig Univ, Fac Med, Clin Pharmacol Dept, Zagazig 44519, Egypt.
   [Hassan, Heba A.] Mutah Univ, Fac Med, Dept Pharmacol, POB 7, Al Karak 61710, Jordan.
C3 Egyptian Knowledge Bank (EKB); Zagazig University; Mutah University
RP Hassan, HA (corresponding author), Zagazig Univ, Fac Med, Clin Pharmacol Dept, Zagazig 44519, Egypt.; Hassan, HA (corresponding author), Mutah Univ, Fac Med, Dept Pharmacol, POB 7, Al Karak 61710, Jordan.
EM HAHanafi@medicine.zu.edu.eg
RI Hassan, Heba/C-2314-2014
OI Hassan, Heba/0000-0003-2822-7947
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NR 69
TC 1
Z9 1
U1 0
U2 5
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0028-1298
EI 1432-1912
J9 N-S ARCH PHARMACOL
JI Naunyn-Schmiedebergs Arch. Pharmacol.
PD APR
PY 2024
VL 397
IS 4
BP 2359
EP 2378
DI 10.1007/s00210-023-02771-4
EA OCT 2023
PG 20
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA LG4P0
UT WOS:001084814300004
PM 37831115
DA 2025-06-11
ER

PT J
AU Johnson, H
   Yates, T
   Leedom, G
   Ramanathan, C
   Puppa, M
   van der Merwe, M
   Tipirneni-Sajja, A
AF Johnson, Hayden
   Yates, Thomas
   Leedom, Gary
   Ramanathan, Chidambaram
   Puppa, Melissa
   van der Merwe, Marie
   Tipirneni-Sajja, Aaryani
TI Multi-Tissue Time-Domain NMR Metabolomics Investigation of
   Time-Restricted Feeding in Male and Female Nile Grass Rats
SO METABOLITES
LA English
DT Article
DE NMR; dietary metabolomics; high-fat diet; time-restricted feeding;
   metabolic syndrome; Nile grass rats; time-domain NMR
ID HIGH-FAT DIET; NUCLEAR-MAGNETIC-RESONANCE; INSULIN-RESISTANCE;
   ADIPOSE-TISSUE; METABOLISM; MODEL; EXPRESSION; DISEASE; OBESITY; WEIGHT
AB Metabolic disease resulting from overnutrition is prevalent and rapidly increasing in incidence in modern society. Time restricted feeding (TRF) dietary regimens have recently shown promise in attenuating some of the negative metabolic effects associated with chronic nutrient stress. The purpose of this study is to utilize a multi-tissue metabolomics approach using nuclear magnetic resonance (NMR) spectroscopy to investigate TRF and sex-specific effects of high-fat diet in a diurnal Nile grass rat model. Animals followed a six-week dietary protocol on one of four diets: chow ad libitum, high-fat ad libitum (HF-AD), high-fat early TRF (HF-AM), or high-fat late TRF (HF-PM), and their liver, heart, and white adipose tissues were harvested at the end of the study and were analyzed by NMR. Time-domain complete reduction to amplitude-frequency table (CRAFT) was used to semi-automate and systematically quantify metabolites in liver, heart, and adipose tissues while minimizing operator bias. Metabolite profiling and statistical analysis revealed lipid remodeling in all three tissues and ectopic accumulation of cardiac and hepatic lipids for HF-AD feeding compared to a standard chow diet. Animals on TRF high-fat diet had lower lipid levels in the heart and liver compared to the ad libitum group; however, no significant differences were noted for adipose tissue. Regardless of diet, females exhibited greater amounts of hepatic lipids compared to males, while no consistent differences were shown in adipose and heart. In conclusion, this study demonstrates the feasibility of performing systematic and time-efficient multi-tissue NMR metabolomics to elucidate metabolites involved in the crosstalk between different metabolic tissues and provides a more holistic approach to better understand the etiology of metabolic disease and the effects of TRF on metabolic profiles.
C1 [Johnson, Hayden; Yates, Thomas; Leedom, Gary; Tipirneni-Sajja, Aaryani] Univ Memphis, Dept Biomed Engn, Memphis, TN 38152 USA.
   [Ramanathan, Chidambaram; Puppa, Melissa; van der Merwe, Marie] Univ Memphis, Coll Hlth Sci, Memphis, TN 38152 USA.
C3 University of Memphis; University of Memphis
RP Tipirneni-Sajja, A (corresponding author), Univ Memphis, Dept Biomed Engn, Memphis, TN 38152 USA.
EM hlihnson@memphis.edu; tcyates1@memphis.edu; galeedom@memphis.edu;
   rchdmbrm@memphis.edu; mpuppa@memphis.edu; myndrmrw@memphis.edu;
   aaryani.sajja@memphis.edu
RI Sajja, Aaryani/AAG-9657-2019; Johnson, Hayden/AAB-6056-2021
OI Johnson, Hayden/0000-0001-9945-195X; Ramanathan,
   Chidambaram/0000-0002-8840-0943; Tipirneni-Sajja,
   Aaryani/0000-0002-3246-8711; van der Merwe, Marie/0000-0001-5683-4790;
   Yates, Thomas/0000-0001-8366-6171
FU University of Memphis; NSF [1531466]; Division Of Chemistry; Direct For
   Mathematical & Physical Scien [1531466] Funding Source: National Science
   Foundation
FX This research was supported by the University of Memphis. This work was
   supported by NSF (#1531466) for use of the JEOL spectrometer in the
   Department of Chemistry at the University of Memphis.
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Z9 4
U1 1
U2 14
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2218-1989
J9 METABOLITES
JI Metabolites
PD JUL
PY 2022
VL 12
IS 7
AR 657
DI 10.3390/metabo12070657
PG 21
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 3H7WT
UT WOS:000832243600001
PM 35888782
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Kaluba, L
   Goma, F
   Guure, C
   Munsaka, S
   Mutale, W
   Heimburger, DC
   Chikopela, T
   Koethe, JR
AF Kaluba, Longa
   Goma, Fastone
   Guure, Chris
   Munsaka, Sody
   Mutale, Wilbroad
   Heimburger, Douglas C.
   Chikopela, Theresa
   Koethe, John R.
TI Immune activation and arterial stiffness in lean adults with HIV on
   antiretroviral therapy
SO SOUTHERN AFRICAN JOURNAL OF HIV MEDICINE
LA English
DT Article
DE endothelial dysfunction; immune activation; lean adults; antiretroviral
   therapy; arterial stiffness
ID T-CELL-ACTIVATION; HUMAN-IMMUNODEFICIENCY-VIRUS; OXIDATIVE STRESS;
   CARDIOVASCULAR-DISEASE; NITRIC-OXIDE; METABOLIC SYNDROME; INFLAMMATION;
   SENESCENCE; MARKERS; EVENTS
AB Background: Greater T-cell activation was associated with reduced vascular compliance amongst persons living with HIV (PLWH) especially among overweight and obese individuals. There is a paucity of data regarding immune activation and arterial stiffness amongst PLWH in sub-Saharan Africa (SSA).
   Objective: To determine the association between immune activation and arterial stiffness in lean PLWH in SSA.
   Method: Forty-eight human immunodeficiency virus positive (HIV+) adults on antiretroviral therapy (ART) >5 years and 26 HIV-negative adults, all with BMI < 25 kg/m2 and no history of CVD, were enrolled. The relationship of vascular compliance with circulating CD4+ and CD8+ naive, memory, activated and senescent T cells, and serum 8-isoprostane was assessed by HIV status.
   Results: Increased immune activation was observed in the CD4+ and CD8+ T cells of PLWH, 16.7% vs. 8.9% and 22.0% vs. 12.4% respectively; p < 0.001 (both). Furthermore, a higher proportion of senescent CD4+ T cells were associated with a lower carotid-femoral pulse wave velocity (cfPWV; p = 0.01), whilst a higher proportion of activated CD8+ T cells were associated with a lower carotid-radial pulse wave velocity (crPWV; p = 0.04), after adjustment for BMI and age. However, PLWH also had a higher median carotid-femoral augmentation index (cfAiX) (21.1% vs. 6.0%; p < 0.05) in comparison to their HIV controls.
   Conclusion: Our population of lean PLWH had increased immune activation and higher cfAiX, a marker of arterial stiffness, compared to HIV-negative persons. The negative association between immune activation and arterial stiffness as measured by crPWV in PLHW on long-term treatment needs further elucidation.
C1 [Kaluba, Longa] Cavendish Univ Zambia, Sch Med, Lusaka, Zambia.
   [Goma, Fastone] Eden Univ, Lusaka, Zambia.
   [Goma, Fastone] Univ Zambia, Sch Med, Dept Physiol Sci, Lusaka, Zambia.
   [Guure, Chris] Univ Ghana, Sch Publ Hlth, Dept Biostat, Legon, Ghana.
   [Munsaka, Sody] Univ Zambia, Sch Hlth Sci, Dept Biomed Sci, Lusaka, Zambia.
   [Mutale, Wilbroad] Univ Zambia, Sch Publ Hlth, Dept Hlth Policy & Management, Lusaka, Zambia.
   [Heimburger, Douglas C.; Koethe, John R.] Vanderbilt Univ, Med Ctr, Vanderbilt Inst Global Hlth, Nashville, TN USA.
   [Heimburger, Douglas C.; Koethe, John R.] Vanderbilt Univ, Med Ctr, Dept Med, Nashville, TN USA.
   [Chikopela, Theresa] Lusaka Apex Univ, Dept Human Physiol, Fac Med, Lusaka, Zambia.
C3 University of Zambia; University of Ghana; University of Zambia;
   University of Zambia; Vanderbilt University; Vanderbilt University
RP Kaluba, L (corresponding author), Cavendish Univ Zambia, Sch Med, Lusaka, Zambia.
EM kalubalonga@gmail.com
RI Koethe, John/LVA-2588-2024; Guure, Chris/H-8071-2019; Munsaka,
   Sody/AAD-9186-2022; Chikopela, Theresa/HTS-2404-2023; Heimburger,
   Douglas/KMA-5000-2024
OI Koethe, John/0000-0001-6490-6942; Banda, Longa/0000-0001-6976-0970;
   Mutale, Wilbroad/0000-0002-4891-6750; Guure, Chris/0000-0001-6595-9587;
   Chikopela, Theresa/0000-0003-4176-2135; Goma,
   Fastone/0000-0002-9159-1621; Munsaka, Sody/0000-0002-6917-3888;
   Heimburger, Douglas/0000-0003-3551-9710
FU Fogarty International Centre of the U.S. National Institutes of Health
   [D43 TW009744]; NIH from NCRR/NIH [UL1 RR024975]; NIH [P30 AI110527];
   National Institutes of Health [K01HL130497]
FX This work was supported by the Fogarty International Centre of the U.S.
   National Institutes of Health under the Award Number D43 TW009744, the
   NIH-funded Vanderbilt Clinical and Translational Science Award from
   NCRR/NIH Grant UL1 RR024975, the NIH-funded Tennessee Centre for AIDS
   Research Grant P30 AI110527, and National Institutes of Health grant
   K01HL130497. The content is solely the responsibility of the authors and
   does not necessarily represent the official views of the National
   Institutes of Health.
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NR 45
TC 4
Z9 4
U1 0
U2 1
PU AOSIS
PI Durbanville
PA Postnet Suite 110, Private Bag x 19, Durbanville, SOUTH AFRICA
SN 1608-9693
EI 2078-6751
J9 S AFR J HIV MED
JI South. Afr. J. HIV Med.
PD MAR 19
PY 2021
VL 22
IS 1
AR a1190
DI 10.4102/sajhivmed.v22i1.1190
PG 9
WC Infectious Diseases; Virology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases; Virology
GA RF9BZ
UT WOS:000635134200001
PM 33824734
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Tannkulu-Küçük, S
   Basaran-Küçükgergin, C
   Sögüt, I
   Tunçdemir, M
   Dogru-Abbasoglu, S
   Seyithanoglu, M
   Koçak, H
   Öner-Iyidogan, Y
AF Tannkulu-Kucuk, Sevda
   Basaran-Kucukgergin, Canan
   Sogut, Ibrahim
   Tuncdemir, Matem
   Dogru-Abbasoglu, Semra
   Seyithanoglu, Muhammed
   Kocak, Hikmet
   Oner-Iyidogan, Yidiz
TI Dietary curcumin and capsaicin: Relationship with hepatic oxidative
   stress and apoptosis in rats fed a high fat diet
SO ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE
LA English
DT Article
DE apoptosis; curcumin; high-fat diet; fatty liver; capsaicin
ID MITOCHONDRIAL DYSFUNCTION; METABOLIC SYNDROME; LIVER; OBESITY;
   ACTIVATION; EXPRESSION; PROTECTION; PREVENTS; ACIDS
AB Background. Apoptosis plays a major role in fatty liver disease. High-fat diets are related to the onset of fatty liver disease and hepatic oxidant-antioxidant imbalance. Curcumin and capsaicin are somewhat beneficial in reducing hepatic triglycerides; this is most likely because they are known to downregulate reactive oxygen species (ROS) and apoptosis.
   Objectives. The aim of this study was to investigate the effects of curcumin and capsaicin on apoptosis through the oxidative effect in an animal model of fatty liver disease.
   Material and methods. Male Sprague-Dawley rats were fed a normal control diet, a high-fat diet (HFD; 60% of total calories from fat), a HFD+curcumin (1.5 g curcumin/kg HFD), a HFD+capsaicin (0.15 g capsaicin/kg HFD), or a HFD+curcumin+capsaicin (1.5 g curcumin and 0.15 g capsaicin/kg HFD). Liver lysate levels of BAX, Bcl-2 and caspase-3 were determined via immunoblotting. Caspase-3 activity was measured with a colorimetric caspase-3 measurement kit. Total antioxidant status (TAS) and total oxidant status (TOS) were assayed using commercial kits. The generation of hepatic ROS was measured with fluorimetry. Fragmentation of DNA was detected using the TUNEL method.
   Results. High-fat diet caused increased expression of BAX and caspase-3, as well as increased TOS and caspase-3 activity, but decreased expression of Bcl-2. HFD+curcumin+capsaicin caused decreased BAX, caspase-3, TOS, and ROS levels as compared to HFD, but increased TAS and Bcl-2. A HFD +curcumin+capsaicin also decreased the number of TUNEL-positive cells.
   Conclusions. These results suggest that supplementation with curcumin and capsaicin balances the hepatic oxidant-antioxidant status and may have a protective role in the apoptotic process in an HFD-induced fatty liver model.
C1 [Tannkulu-Kucuk, Sevda; Kocak, Hikmet] Istanbul Bilim Univ, Fac Med, Dept Biochem, Istanbul, Turkey.
   [Basaran-Kucukgergin, Canan; Dogru-Abbasoglu, Semra; Oner-Iyidogan, Yidiz] Istanbul Univ, Istanbul Fac Med, Dept Biochem, Istanbul, Turkey.
   [Sogut, Ibrahim] Istanbul Bilim Univ, Vocat Sch Hlth Serv, Istanbul, Turkey.
   [Tuncdemir, Matem] Istanbul Univ, Cerrahpasa Med Fac, Dept Med Biol, Istanbul, Turkey.
   [Seyithanoglu, Muhammed] Kahramanmaras Sutcu Imam Univ, Fac Med, Dept Biochem, Kahramanmaras, Turkey.
C3 Demiroglu Bilim University; Istanbul University; Demiroglu Bilim
   University; Istanbul University - Cerrahpasa; Istanbul University;
   Kahramanmaras Sutcu Imam University
RP Tannkulu-Küçük, S (corresponding author), Istanbul Bilim Univ, Fac Med, Dept Biochem, Istanbul, Turkey.
EM sevda.kucuk@istanbulbillm.edu.tr
RI Öner-İyidoğan, Yıldız/AAD-9034-2020; Tunçdemir, Matem/P-3054-2018;
   Sogut, İbrahim/AAU-9306-2021; Seyithanoglu, Muhammed/LUZ-2475-2024;
   Abbasoglu, Semra/AAD-9014-2020; KOCAK, Hikmet/C-2969-2016
OI Oner-Iyidogan, Yildiz/0000-0001-6956-8794; seyithanoglu,
   muhammed/0000-0002-8027-7549; KOCAK, Hikmet/0000-0003-1720-9102
FU Research Fund of Istanbul University, Turkey [55331, BEK-2017-24926]
FX This work was supported by the Research Fund of Istanbul University,
   Turkey, project No. 55331 and BEK-2017-24926.
CR [Anonymous], [No title captured]
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NR 40
TC 12
Z9 12
U1 1
U2 21
PU WROCLAW MEDICAL UNIV
PI WROCLAW
PA UL K MARCINKOWSKIEGO 2-6, WROCLAW, 50-368, POLAND
SN 1899-5276
EI 2451-2680
J9 ADV CLIN EXP MED
JI Adv. Clin. Exp. Med.
PD AUG
PY 2019
VL 28
IS 8
BP 1013
EP 1020
DI 10.17219/acem/94145
PG 8
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA IV1PK
UT WOS:000484049900002
PM 30993920
OA Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Cichero, E
   Fresia, C
   Guida, L
   Booz, V
   Millo, E
   Scotti, C
   Iamele, L
   de Jonge, H
   Galante, D
   De Flora, A
   Sturla, L
   Vigliarolo, T
   Zocchi, E
   Fossa, P
AF Cichero, Elena
   Fresia, Chiara
   Guida, Lucrezia
   Booz, Valeria
   Millo, Enrico
   Scotti, Claudia
   Iamele, Luisa
   de Jonge, Hugo
   Galante, Denise
   De Flora, Antonio
   Sturla, Laura
   Vigliarolo, Tiziana
   Zocchi, Elena
   Fossa, Paola
TI Identification of a high affinity binding site for abscisic acid on
   human lanthionine synthetase component C-like protein 2
SO INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
LA English
DT Article
DE Human lanthionine synthetase component C-like protein 2 (LANCL2);
   Abscisic acid (ABA); Binding affinity; Computational studies;
   Site-directed mutagenesis
ID CYCLIC ADP-RIBOSE; TISSUE-SPECIFIC EXPRESSION; HYDE SCORING FUNCTION;
   HUMAN LANCL2; DOCKING; 2ND-MESSENGER; RECEPTOR; INHIBITORS; DESIGN
AB Lanthionine synthetase component C-like protein 2 (LANCL2) has been identified as the mammalian receptor mediating the functional effects of the universal stress hormone abscisic acid (ABA) in mammals. ABA stimulates insulin independent glucose uptake in myocytes and adipocytes via LANCL2 binding in vitro, improves glucose tolerance in vivo and induces brown fat activity in vitro and in vivo. The emerging role of the ABA/LANCL2 system in glucose and lipid metabolism makes it an attractive target for pharmacological interventions in diabetes mellitus and the metabolic syndrome. The aim of this study was to investigate the presence of ABA binding site (s) on LANCL2 and identify the amino acid residues involved in ABA binding. Equilibrium binding assays ([H-3) ABA saturation binding and surface plasmon resonance analysis) suggested multiple ABA-binding sites, prompting us to perform a computational study that indicated one putative high-affinity and two low-affinity binding sites. Site-directed mutagenesis (single mutant R118I, triple mutants R118I/R221/K3621 and R118I/S41A/E46I) and equilibrium binding experiments on the mutated LANCL2 proteins identified a high-affinity ABA-binding site involving R118, with a K-D of 2.6 nM +/- 1.2 nM, as determined by surface plasmon resonance. Scatchard plot analysis of binding curves from both types of equilibrium binding assays revealed a Hill coefficient > 1, suggesting cooperativity of ABA binding to LANCL2. Identification of the high-affinity ABA-binding site is expected to allow the design of ABA agonists/antagonists, which will help to understand the role of the ABA/LANCL2 system in human physiology and disease.
C1 [Cichero, Elena; Fossa, Paola] Univ Genoa, Sch Med & Pharmaceut Sci, Dept Pharm, Sect Med Chem, Viale Benedetto 15 3, I-16132 Genoa, Italy.
   [Fresia, Chiara; Guida, Lucrezia; Booz, Valeria; Millo, Enrico; De Flora, Antonio; Sturla, Laura; Vigliarolo, Tiziana; Zocchi, Elena] Univ Genoa, Sch Med & Pharmaceut Sci, Dept Expt Med, Sect Biochem, Viale Benedetto 15 1, I-16132 Genoa, Italy.
   [Millo, Enrico; Sturla, Laura; Zocchi, Elena] Univ Genoa, CEBR, Via GB Mariano 10, I-16132 Genoa, Italy.
   [Scotti, Claudia; Iamele, Luisa; de Jonge, Hugo] Univ Pavia, Dept Mol Med, Immunol & Gen Pathol Unit, Via Ferrate 9, I-27100 Pavia, Italy.
   [Scotti, Claudia; Iamele, Luisa; de Jonge, Hugo] Ardis Srl, Via Taramelli 24, I-27100 Pavia, Italy.
   [Galante, Denise] CNR, Inst Macromol Studies, Genoa, Italy.
C3 University of Genoa; University of Genoa; University of Genoa;
   University of Pavia; Consiglio Nazionale delle Ricerche (CNR); Istituto
   per lo Studio delle Macromolecole (ISMAC-CNR)
RP Fossa, P (corresponding author), Univ Genoa, Sch Med & Pharmaceut Sci, Dept Pharm, Sect Med Chem, Viale Benedetto 15 3, I-16132 Genoa, Italy.; Sturla, L; Vigliarolo, T (corresponding author), Univ Genoa, Sch Med & Pharmaceut Sci, Dept Expt Med, Sect Biochem, Viale Benedetto 15 1, I-16132 Genoa, Italy.; Sturla, L (corresponding author), Univ Genoa, CEBR, Via GB Mariano 10, I-16132 Genoa, Italy.
EM laurasturla@unige.it; tiziana.vigliarolo@edu.unige.it;
   fossa@difar.unige.it
RI de Jonge, Hugo/AAI-1861-2019; Scotti, Claudia/A-7126-2012; de Jonge,
   Hugo/D-4036-2018; Galante, Denise/K-3178-2018; Millo, Enrico/K-3218-2018
OI Cichero, Elena/0000-0001-6781-9289; de Jonge, Hugo/0000-0003-2777-4084;
   Galante, Denise/0000-0002-6326-5888; Fossa, Paola/0000-0001-9386-0445;
   Millo, Enrico/0000-0002-4019-0051; FRESIA, CHIARA
   MARTA/0000-0002-9177-4655
FU University of Genova; MIUR [RBFR1299K0_002, 2010MCLBCZ_004]
FX This work was financially supported by the University of Genova and by
   MIUR (grant #RBFR1299K0_002 to CF; grant #2010MCLBCZ_004 to EZ).
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NR 38
TC 19
Z9 19
U1 0
U2 23
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 1357-2725
EI 1878-5875
J9 INT J BIOCHEM CELL B
JI Int. J. Biochem. Cell Biol.
PD APR
PY 2018
VL 97
BP 52
EP 61
DI 10.1016/j.biocel.2018.02.003
PG 10
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA GD8JG
UT WOS:000430758100006
PM 29421190
DA 2025-06-11
ER

PT J
AU Kent, LM
   Morton, DP
   Rankin, PM
   Gobble, JE
   Diehl, HA
AF Kent, Lillian M.
   Morton, Darren P.
   Rankin, Paul M.
   Gobble, John E.
   Diehl, Hans A.
TI Gender Differences in Effectiveness of the Complete Health Improvement
   Program (CHIP)
SO JOURNAL OF NUTRITION EDUCATION AND BEHAVIOR
LA English
DT Article
DE chronic disease; health behavior; risk factors; men; women
ID LIFE-STYLE INTERVENTION; CORONARY RISK REDUCTION; WEIGHT-LOSS; METABOLIC
   SYNDROME; HEART-DISEASE; OBESITY; DIET; FAT; CHOLESTEROL; MAINTENANCE
AB Objective: To determine the differential effect of gender on outcomes of the Complete Health Improvement Program, a chronic disease lifestyle intervention program.
   Design: Thirty-day cohort study.
   Setting: One hundred thirty-six venues around North America, 2006 to 2009.
   Participants: A total of 5,046 participants (33.5% men, aged 57.9 +/- 13.0 years; 66.5% women, aged 57.0 +/- 12.9 years).
   Intervention: Diet, exercise, and stress management. Main Outcome Measures: Body mass index, diastolic blood pressure, systolic blood pressure, lipids, and fasting plasma glucose (FPG).
   Analysis: The researchers used t test and McNemar chi-square test of proportions, at P < .05.
   Results: Reductions were significantly greater for women for high-density lipoprotein (9.1% vs 7.6%) but greater for men for low-density lipoprotein cholesterol (16.3% vs 11.5%), total cholesterol (TC) (13.2% vs 10.1%), triglycerides (11.4% vs 5.6%), FPG (8.2% vs 5.3%), body mass index (3.5% vs 3%), diastolic blood pressure (5.5% vs 5.1%), and TC/high-density lipoprotein (6.3% vs 1.4%) but not different for systolic blood pressure (6% vs 5%). The greatest reductions were in participants with the highest baseline TC, low-density lipoprotein, triglycerides, and FPG classifications.
   Conclusions and Implications: The Complete Health Improvement Program effectively reduced chronic disease risk factors among both genders, but particularly men, with the largest reductions occurring in individuals at greatest risk. Physiological or behavioral factor explanations, including differences in adiposity and hormones, dietary intake, commitment and social support, are explored. Researchers should consider addressing gender differences in food preferences and eliciting commitment and differential support modes in the development of lifestyle interventions such as the Complete Health Improvement Program.
C1 [Kent, Lillian M.; Morton, Darren P.; Rankin, Paul M.] Avondale Coll Higher Educ, Lifestyle Res Ctr, Cooranbong, NSW 2265, Australia.
   [Gobble, John E.] Med Nutr Therapy Northwest, Clackamas, OR USA.
   [Diehl, Hans A.] Lifestyle Med Inst, Loma Linda, CA USA.
C3 Avondale University
RP Kent, LM (corresponding author), Avondale Coll Higher Educ, Lifestyle Res Ctr, 582 Freemans Dr,POB 19, Cooranbong, NSW 2265, Australia.
EM lillian.kent@avondale.edu.au
RI Morton, David/K-2388-2014
OI Kent, Lillian/0000-0001-9518-7303; Morton, Darren/0000-0002-2836-7838;
   Gobble, John/0000-0003-0566-9347
CR ABC, 2014, ABC NEWS
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NR 50
TC 5
Z9 7
U1 0
U2 21
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1499-4046
EI 1878-2620
J9 J NUTR EDUC BEHAV
JI J. Nutr. Educ. Behav.
PD JAN-FEB
PY 2015
VL 47
IS 1
BP 44
EP 52
DI 10.1016/j.jneb.2014.08.016
PG 9
WC Education, Scientific Disciplines; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Education & Educational Research; Nutrition & Dietetics
GA AW9GC
UT WOS:000346564400008
PM 25312267
OA hybrid
DA 2025-06-11
ER

PT J
AU Oda, E
AF Oda, Eiji
TI A decrease in total bilirubin predicted hyper-LDL cholesterolemia in a
   health screening population
SO ATHEROSCLEROSIS
LA English
DT Article
DE Bilirubin; LDL cholesterol; Antioxidant; Cardiovascular disease
ID SERUM TOTAL BILIRUBIN; CORONARY-ARTERY-DISEASE; ISCHEMIC-HEART-DISEASE;
   METABOLIC SYNDROME; GILBERT-SYNDROME; OXIDATIVE STRESS; RISK;
   ASSOCIATION; ANTIOXIDANT; MEN
AB Objective: To investigate cross-sectional and longitudinal associations between serum total bilirubin (TB) and LDL cholesterol.
   Methods: It is a retrospective observational study. Cross-sectional and longitudinal associations between TB and hyper-LDL cholesterolemia were investigated in a health screening population. Odds ratios (ORs) of coexisting hyper-LDL cholesterolemia for TB were calculated in 3,866 subjects, Spearman's correlation coefficients between baseline TB and LDL cholesterol at baseline and after 4 years were calculated in 1,735 subjects who did not use antihyperlipidemic drugs and hazard ratios (HRs) of incident hyper-LDL cholesterolemia for TB were calculated in 1,992 followed subjects.
   Results: The ORs (p values) of coexisting hyper-LDL cholesterolemia for each 1 SD increase in TB was 1.04 (0.998) adjusted for sex, age, smoking, LDL cholesterol and other confounders. Spearman's correlation coefficients (p values) between baseline TB and LDL cholesterol at baseline and after 4 years and changes in LDL cholesterol were 0.026 (0.271), 0.078 (0.001) and 0.062 (0.010), respectively. Among 1,992 followed subjects, 481 developed hyper-LDL cholesterolemia during 4 years (60.4 per 1,000 person-years). The HRs (95% confidence intervals; p values) of incident hyper-LDL cholesterolemia for each 1 SD increase in TB was 0.86 (0.77-0.96; 0.006) adjusted for sex, age, smoking, LDL cholesterol, body mass index, triglycerides, HDL cholesterol, fasting glucose and other confounders. The quintiles of TB were significantly associated with the incident hyper-LDL cholesterolemia adjusted for the above covariates (p for trend = 0.008).
   Conclusion: A decrease in TB predicted incident hyper-LDL cholesterolemia in a health screening population. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
C1 Tachikawa Med Ctr, Med Check Up Ctr, Nagaoka, Niigata 9400053, Japan.
RP Oda, E (corresponding author), Tachikawa Med Ctr, Med Check Up Ctr, Nagachou 2-2-16, Nagaoka, Niigata 9400053, Japan.
EM ijie@venus.sannet.ne.jp
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NR 34
TC 16
Z9 17
U1 0
U2 6
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0021-9150
EI 1879-1484
J9 ATHEROSCLEROSIS
JI Atherosclerosis
PD AUG
PY 2014
VL 235
IS 2
BP 334
EP 338
DI 10.1016/j.atherosclerosis.2014.05.927
PG 5
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA AP9PF
UT WOS:000342411000912
PM 24911637
DA 2025-06-11
ER

PT J
AU Gray, B
   Muhlhausler, BS
   Davies, PSW
   Vitetta, L
AF Gray, Belinda
   Muhlhausler, Beverly Sara
   Davies, Peter Stephen Wynford
   Vitetta, Luis
TI Liver enzymes but not free fatty acid levels predict markers of insulin
   sensitivity in overweight and obese, nondiabetic adults
SO NUTRITION RESEARCH
LA English
DT Article
DE Human; Obesity; Insulin; Liver; n-3 Fatty acids; n-6 Fatty acids
ID GAMMA-GLUTAMYL-TRANSFERASE; ADIPOSE-SPECIFIC PROTEIN; METABOLIC
   SYNDROME; PHYSICAL-ACTIVITY; CARDIOVASCULAR RISK; DIABETES-MELLITUS;
   OXIDATIVE STRESS; ENERGY DENSITY; N-6/N-3 RATIO; RESISTANCE
AB Although obesity is a key predisposing risk factor in the development of insulin resistance (IR) and type 2 diabetes mellitus, not all obese individuals develop IR. This study aimed to identify key anthropometric and biochemical parameters that predict insulin sensitivity in overweight and obese adults. Based On previous literature, we hypothesized that markers of insulin sensitivity would be negatively correlated with plasma concentrations of free fatty acids and liver enzymes. Forty nondiabetic adult participants (body mass index >= 25.0kg/m(2)) were recruited. Data collection included anthropometric measurements and fasting plasma samples for the quantification of liver enzymes (alanine transaminase, aspartate transaminase, gamma-glutamyl transpeptidase), blood lipid profile, and markers of insulin sensitivity. Questionnaires relating to dietary intake, physical activity, and fatigue were also completed. Insulin and Homeostasis Model of Assessment (HOMA) scores were significantly correlated with indirect measures of central obesity (P < .05). Glycosylated hemoglobin, insulin, and HOMA scores for IR were all positively correlated with selected liver function markers (P < .05). Scores of HOMA-IR were significantly positively correlated with plasma phospholipid levels of n-3 fatty acids (P = .04) and ratio of n-3/n-6 fatty acids (P < .05) and negatively correlated with n-6 fatty acids (P = .03). No significant correlations were found between markers of insulin sensitivity and cholesterol levels, physical activity, or self-reported fatigue. These results have reinforced the integral role of liver function in the development of IR. Despite previous data linking elevations in free fatty acid to the development of IR, we found no relationship between these variables in this study. (C) 2013 Elsevier Inc. All rights reserved.
C1 [Gray, Belinda; Davies, Peter Stephen Wynford] Univ Queensland, Royal Childrens Hosp, Childrens Nutr Res Ctr, Queensland Childrens Med Res Inst, Herston, Qld 4029, Australia.
   [Gray, Belinda; Vitetta, Luis] Univ Queensland, Princess Alexandra Hosp, Sch Med, Ctr Integrat Clin & Mol Med, Woolloongabba, Qld, Australia.
   [Gray, Belinda; Davies, Peter Stephen Wynford; Vitetta, Luis] Univ Queensland, Sch Med, Adelaide, SA, Australia.
   [Muhlhausler, Beverly Sara] Univ Adelaide, Sch Agr Food & Wine, FOODplus Res Ctr, Adelaide, SA, Australia.
C3 University of Queensland; Royal Children's Hospital Brisbane; Princess
   Alexandra Hospital; University of Queensland; University of Queensland;
   University of Adelaide
RP Davies, PSW (corresponding author), Univ Queensland, Royal Childrens Hosp, Childrens Nutr Res Ctr, Cnr 4th Ave & Back Rd, Herston, Qld 4029, Australia.
EM ps.davies@uq.edu.au
RI Vitetta, Luis/F-4206-2010; Davies, Peter/KLZ-9236-2024
OI Vitetta, Luis/0000-0002-7490-9298
FU Centre for Integrative Clinical and Molecular Medicine, The University
   of Queensland; FIT Bioceuticals
FX This research did not receive any specific grant from any funding agency
   in public, commercial, or not-for-profit sector. This project was funded
   by the Centre for Integrative Clinical and Molecular Medicine, The
   University of Queensland. L. Vitetta acknowledges receipt of scholarship
   funds for B. Gray from FIT Bioceuticals.
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NR 50
TC 15
Z9 17
U1 0
U2 12
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0271-5317
J9 NUTR RES
JI Nutr. Res.
PD OCT
PY 2013
VL 33
IS 10
BP 781
EP 788
DI 10.1016/j.nutres.2013.07.019
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 231WL
UT WOS:000325449000001
PM 24074735
OA Green Published
DA 2025-06-11
ER

PT J
AU Valenzuela, R
   Espinosa, A
   González-Mañán, D
   D'Espessailles, A
   Fernández, V
   Videla, LA
   Tapia, G
AF Valenzuela, Rodrigo
   Espinosa, Alejandra
   Gonzalez-Manan, Daniel
   D'Espessailles, Amanda
   Fernandez, Virginia
   Videla, Luis A.
   Tapia, Gladys
TI N-3 Long-Chain Polyunsaturated Fatty Acid Supplementation Significantly
   Reduces Liver Oxidative Stress in High Fat Induced Steatosis
SO PLOS ONE
LA English
DT Article
ID INSULIN-RESISTANCE; EICOSAPENTAENOIC ACID; DESATURASE ACTIVITY;
   METABOLIC SYNDROME; HEPATIC STEATOSIS; ADIPOSE-TISSUE; DISEASE;
   OMEGA-3-FATTY-ACIDS; RATIO; INFLAMMATION
AB Omega-3 (n-3) long-chain polyunsaturated fatty acids (n-3 LCPUFA) are associated with several physiological functions, suggesting that their administration may prevent non transmissible chronic diseases. Therefore, we investigate whether dietary n-3 LCPUFA supplementation triggers an antioxidant response preventing liver steatosis in mice fed a high fat diet (HFD) in relation to n-3 LCPUFA levels. Male C57BL/6J mice received (a) control diet (10% fat, 20% protein, 70% carbohydrate), (b) control diet plus n-3 LCPUFA (108 mg/kg/day eicosapentaenoic acid plus 92 mg/kg/day docosahexaenoic acid), (c) HFD (60% fat, 20% protein, 20% carbohydrate), or (d) HFD plus n-3 LCPUFA for 12 weeks. Parameters of liver steatosis, glutathione status, protein carbonylation, and fatty acid analysis were determined, concomitantly with insulin resistance and serum tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1 beta, and IL-6 levels. HFD significantly increased total fat and triacylglyceride contents with macrovesicular steatosis, concomitantly with higher fasting serum glucose and insulin levels, HOMA, and serum TNF-alpha, IL-1 beta, and IL-6. Reduced and total liver glutathione contents were diminished by HFD, with higher GSSG/GSH ratio and protein carbonylation, n-3 LCPUFA depletion and elevated n-6/n-3 ratio over control values. These changes were either reduced or normalized to control values in animals subjected to HFD and n-3 LCPUFA, with significant increased hepatic total n-3 LCPUFA content and reduced n-6/n-3 ratio being observed after n-3 LCPUFA supplementation alone. So, repletion of liver n-3 LCPUFA levels by n-3 LCPUFA dietary supplementation in HFD obese mice reduces hepatic lipid content, with concomitant antioxidant and anti-inflammatory responses favouring insulin sensitivity.
C1 [Gonzalez-Manan, Daniel; D'Espessailles, Amanda; Fernandez, Virginia; Videla, Luis A.; Tapia, Gladys] Univ Chile, Fac Med, Mol & Clin Pharmacol Program, Inst Biomed Sci, Santiago 7, Chile.
   [Valenzuela, Rodrigo] Univ Chile, Fac Med, Sch Nutr & Dietet, Santiago 7, Chile.
   [Espinosa, Alejandra] Univ Chile, Fac Med, Sch Med Technol, Santiago 7, Chile.
C3 Universidad de Chile; Universidad de Chile; Universidad de Chile
RP Tapia, G (corresponding author), Univ Chile, Fac Med, Mol & Clin Pharmacol Program, Inst Biomed Sci, Santiago 7, Chile.
EM gtapia@med.uchile.cl
RI Espinosa, Alejandra/ISB-7050-2023
FU FONDECYT (National Fund for Scientific and Technological Development)
   [1110043]
FX This work was supported by grant 1110043 from FONDECYT (National Fund
   for Scientific and Technological Development) to G. T., Chile. The
   funders had no role in study design, data collection and analysis,
   decision to publish, or preparation of the manuscript.
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NR 44
TC 99
Z9 103
U1 1
U2 19
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD OCT 17
PY 2012
VL 7
IS 10
AR e46400
DI 10.1371/journal.pone.0046400
PG 8
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 038AF
UT WOS:000311146900015
PM 23082120
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Liu, YX
   Wang, D
   Zhang, D
   Lv, YC
   Wei, Y
   Wu, W
   Zhou, F
   Tang, MM
   Mao, T
   Li, MM
   Ji, BP
AF Liu, Yixiang
   Wang, Dan
   Zhang, Di
   Lv, Yechun
   Wei, Ying
   Wu, Wei
   Zhou, Feng
   Tang, Miaomiao
   Mao, Ting
   Li, Mengmeng
   Ji, Baoping
TI Inhibitory Effect of Blueberry Polyphenolic Compounds on Oleic
   Acid-Induced Hepatic Steatosis in Vitro
SO JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
LA English
DT Article
DE Blueberries; polyphenols; nonalcoholic fatty liver; triglyceride; oleic
   acid; phenolic acid
ID FATTY LIVER-DISEASE; PHENOLIC-ACIDS; LIPID-ACCUMULATION; OXIDATIVE
   STRESS; CHLOROGENIC ACID; ANTHOCYANINS; COFFEE; STEATOHEPATITIS;
   IDENTIFICATION; AMELIORATION
AB Nonalcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases worldwide and is closely associated with metabolic syndromes, such as obesity, diabetes, and insulin resistance. Nonalcoholic fatty liver (NAFL), also called simple steatosis, is the initial phase of NAFLD, which is accompanied the characteristic pathological overaccumulation of lipids without inflammation. To prevent NAFLD from reaching the NAFL stage through dietary therapy, in the present work, wild Chinese blueberries (Vacciniun spp.) were selected for their well-known benefits in inhibiting metabolic syndrome. After being purified from wild Chinese blueberries, polyphenol-rich extracts were subsequently separated into three fractions, namely, anthocyanin-rich fraction, phenolic acid-rich fraction, and ethyl acetate extract. The inhibition of oleic acid (OA)-induced triglyceride (TG) deposition in HepG 2 cells was referred to as the potential activity of preventing NAFL. Biochemical indicators, such as cytotoxicity, TG level, levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST), and intracellular reactive oxygen species, were used to evaluate the analogous pathological stage of NAFLD. The results show that OA <= 1.0 mM exhibits a dose-dependent induction of TG accumulation, and no inflammation was observed based on the changes in ALT and AST levels. Therefore, 1.0 mM OA was used to simulate an in vitro fatty liver. Blueberry polyphenol-rich extract efficiently inhibited OA-induced TG accumulation in HepG2 cells, and the phenolic acid-rich fraction performed efficiently. Seven phenolic acids were subsequently identified using a high-performance liquid chromatography assay, and the main types were caffeic, chlorogenic, ferulic, p-coumaric, and cinnamic acids. These phenolic acid standards also displayed good efficiency in inhibiting TG accumulation in HepG2 cells. These results imply that wild Chinese blueberries have a potential preventive effect on NAFLD in its early stage, and phenolic acids are the most efficient component.
C1 [Liu, Yixiang; Wang, Dan; Zhang, Di; Lv, Yechun; Wei, Ying; Zhou, Feng; Tang, Miaomiao; Mao, Ting; Li, Mengmeng; Ji, Baoping] China Agr Univ, Coll Food Sci & Nutr Engn, Funct Food Res Lab, Beijing 100083, Peoples R China.
   [Wu, Wei] China Agr Univ, Coll Engn, Beijing 100083, Peoples R China.
C3 China Agricultural University; China Agricultural University
RP Ji, BP (corresponding author), China Agr Univ, Coll Food Sci & Nutr Engn, Funct Food Res Lab, Tsinghua E Rd 17, Beijing 100083, Peoples R China.
EM lyxcau@163.com
RI Li, Mengmeng/G-6932-2013
FU National Key Technology R&D Program, The People's Republic of China
   [2011BAD08B03-01]
FX This work was supported by the National Key Technology R&D Program for
   the 12th five-year plan, The People's Republic of China (Project No.
   2011BAD08B03-01).
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NR 47
TC 68
Z9 76
U1 1
U2 103
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0021-8561
EI 1520-5118
J9 J AGR FOOD CHEM
JI J. Agric. Food Chem.
PD NOV 23
PY 2011
VL 59
IS 22
BP 12254
EP 12263
DI 10.1021/jf203136j
PG 10
WC Agriculture, Multidisciplinary; Chemistry, Applied; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture; Chemistry; Food Science & Technology
GA 847SM
UT WOS:000296992800045
PM 21999238
DA 2025-06-11
ER

PT J
AU Vecoli, C
   Cao, J
   Neglia, D
   Inoue, K
   Sodhi, K
   Vanella, L
   Gabrielson, KK
   Bedja, D
   Paolocci, N
   L'Abbate, A
   Abraham, NG
AF Vecoli, C.
   Cao, J.
   Neglia, D.
   Inoue, K.
   Sodhi, K.
   Vanella, L.
   Gabrielson, K. K.
   Bedja, D.
   Paolocci, N.
   L'Abbate, A.
   Abraham, N. G.
TI Apolipoprotein A-I Mimetic Peptide L-4F Prevents Myocardial and Coronary
   Dysfunction in Diabetic Mice
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Article
DE DIABETES; INFLAMMATION; OXIDATIVE STRESS; INSULIN SENSITIVITY;
   ADIPONECTIN; HEME OXYGENASE
ID IMPROVES INSULIN SENSITIVITY; HEME OXYGENASE-1; ENDOTHELIAL DYSFUNCTION;
   ISCHEMIA-REPERFUSION; METABOLIC SYNDROME; PERFUSED HEART;
   ADIPOSE-TISSUE; ADIPONECTIN; APOPTOSIS; MECHANISMS
AB Diabetes is a major health problem associated with adverse cardiovascular outcomes. The apolipoprotein A-I mimetic peptide L-4F is a putative anti-diabetic drug, has antioxidant and anti-inflammatory proprieties and improves endothelial function. In obese mice L-4F increases adiponectin levels, improving insulin sensitivity, and reducing visceral adiposity. We hypothesized that the pleiotropic actions of L-4F can prevent heart and coronary dysfunction in a mouse model of genetically induced Type II diabetes. We treated db/db mice with either L-4F or vehicle for 8 weeks. Trans-thoracic echocardiography was performed; thereafter, isolated hearts were subjected to ischemia/reperfusion (IR). Glucose, insulin, adiponectin, and pro-inflammatory cytokines (IL-1 beta, TNF-alpha, MCP-1) were measured in plasma and HO-1, pAMPK, peNOS, iNOS, adiponectin, and superoxide in cardiac tissue. In db/db mice L-4F decreased accumulation of subcutaneous and total fat, and increased insulin sensitivity and adiponectin levels while lowering inflammatory cytokines (P < 0.05). L-4F normalized in vivo left ventricular (LV) function of db/db mice, increasing (P < 0.05) fractional shortening and decreasing (P < 0.05) LV dimensions. In I/R experiments, L-4F prevented coronary microvascular resistance from increasing and LV function from deteriorating in the db/db mice. These changes were associated with increased cardiac expression of HO-1, pAMPK, peNOS, and adiponectin and decreased levels of superoxide and iNOS (P < 0.01). In the present study we showed that L-4F prevented myocardial and coronary functional abnormalities in db/db mice. These effects were associated with stimulation of HO-1 resulting in increased levels of anti-inflammatory, anti-oxidative, and vasodilatatory action through a mechanism involving increased levels of adiponectin, pAMPK, and peNOS. J. Cell. Biochem. 112: 2616-2626, 2011. (C) 2011 Wiley-Liss, Inc.
C1 [Neglia, D.] CNR Inst Clin Physiol, I-56124 Pisa, Italy.
   [Vecoli, C.; L'Abbate, A.] Scuola Super Sant Anna, Pisa, Italy.
   [Vecoli, C.; Gabrielson, K. K.; Bedja, D.; Paolocci, N.] Johns Hopkins Univ, Dept Cardiol, Baltimore, MD USA.
   [Cao, J.] Chinese Peoples Liberat Army Gen Hosp, Dept Geriatr Cardiol, Beijing, Peoples R China.
   [Neglia, D.] Fdn Toscana G Monasterio, Pisa, Italy.
   [Inoue, K.; Sodhi, K.] New York Med Coll, Dept Pharmacol, Valhalla, NY USA.
   [Vanella, L.] Univ Toledo, Coll Med, Dept Physiol & Pharmacol, Toledo, OH 43606 USA.
   [Paolocci, N.] Univ Perugia, Dept Clin & Expt Med, Gen Pathol & Immunol Sect, I-06100 Perugia, Italy.
   [Abraham, N. G.] Univ Toledo, Dept Physiol & Pharmacol, Toledo, OH 43606 USA.
C3 Consiglio Nazionale delle Ricerche (CNR); Istituto di Fisiologia Clinica
   (IFC-CNR); Scuola Superiore Sant'Anna; Johns Hopkins University; Chinese
   People's Liberation Army General Hospital; New York Medical College;
   University System of Ohio; University of Toledo; University of Perugia;
   University System of Ohio; University of Toledo
RP Neglia, D (corresponding author), CNR Inst Clin Physiol, Via G Moruzzi 1, I-56124 Pisa, Italy.
EM dneglia@ifc.cnr.it
RI Neglia, Danilo/AAR-6384-2020; paolocci, nazareno/A-7124-2009; Vecoli,
   Cecilia/K-8613-2016; Vanella, Luca/J-7354-2016
OI Vecoli, Cecilia/0000-0002-5921-3604; Vanella, Luca/0000-0002-6314-6029;
   Paolocci, Nazareno/0000-0001-7011-997X; Neglia,
   Danilo/0000-0003-0016-9538
FU Scuola Superiore Sant'Anna; IFC-CNR; American Heart Association;
   National Institutes of Health [HL55601, DK068134, HL34300, HL075265,
   R01HL091923]
FX Grant sponsor: Scuola Superiore Sant'Anna; Grant sponsor: IFC-CNR; Grant
   sponsor: American Heart Association; Grant sponsor: National Institutes
   of Health; Grant numbers: HL55601, DK068134, HL34300, HL075265,
   R01HL091923.
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NR 52
TC 30
Z9 34
U1 0
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0730-2312
EI 1097-4644
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PD SEP
PY 2011
VL 112
IS 9
BP 2616
EP 2626
DI 10.1002/jcb.23188
PG 11
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA 818QN
UT WOS:000294769500045
PM 21598304
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Agil, A
   Navarro-Alarcón, M
   Ruiz, R
   Abuhamadah, S
   El-Mir, MY
   Vázquez, GF
AF Agil, Ahmad
   Navarro-Alarcon, Miguel
   Ruiz, Rosario
   Abuhamadah, Sawsan
   El-Mir, Mohamad-Yehia
   Fernandez Vazquez, Gumersindo
TI Beneficial effects of melatonin on obesity and lipid profile in young
   Zucker diabetic fatty rats
SO JOURNAL OF PINEAL RESEARCH
LA English
DT Article
DE dyslipidemia; melatonin; obesity; young male ZDF rats
ID REDUCES BLOOD-PRESSURE; BODY-WEIGHT; SERUM-CHOLESTEROL; PLASMA LEPTIN;
   INSULIN; DIET; INHIBITION; ADIPOSITY; STRESS; LIVER
AB The study objective was to investigate the effects of melatonin on obesity and obesity-associated systolic hypertension and dyslipidemia in young male Zucker diabetic fatty (ZDF) rats, an experimental model of the metabolic syndrome. ZDF rats (n = 30) and lean littermates (ZL) (n = 30) were used. At 6 wk of age, both lean and fatty animals were subdivided into three groups (n = 10): naive (N), vehicle-treated (V), and melatonin-treated (M) (10 mg/kg/day) for 6 wk. Vehicle and melatonin were added to the drinking water. Melatonin reduced mean weight gain (51 +/- 2/100 g BW) versus N-ZDF group (58 +/- 3, P < 0.05) without food intake differences. M-ZDF rats showed an apparent reduction in systolic hypertension that proved not to be statistically significant, and a significant improvement in dyslipidemia, with a reduction in hypertriglyceridemia from 580 +/- 40 to 420.6 +/- 40.9 mg/dL (P < 0.01). Melatonin raised high-density-lipoprotein (HDL) cholesterol in ZDF (from 81.6 +/- 4.9 to 103.1 +/- 4.5 mg/dL, P < 0.01) and ZL rats (from 62.8 +/- 4.8 to 73.5 +/- 4.8 mg/dL, P < 0.05) and significantly reduced low-density-lipoprotein (LDL) cholesterol in ZDF rats from 5.20 +/- 0.4 to 4.14 +/- 0.3 mg/dL (P < 0.05) but had no effect on total cholesterol levels. To our knowledge, this is the first evidence of a positive effect of melatonin on overweight and lipid pattern of obese Zucker diabetic rats, supporting the proposition that melatonin administration may ameliorate overweight and lipid metabolism in humans. Because these benefits occurred in youth, before advanced metabolic and vascular complications, melatonin might help to prevent cardiovascular disease associated with obesity and dyslipidemia.
C1 [Agil, Ahmad] Univ Granada, Sch Med, Dept Pharmacol, E-18012 Granada, Spain.
   [Agil, Ahmad] Univ Granada, Sch Med, Inst Neurosci, E-18012 Granada, Spain.
   [Navarro-Alarcon, Miguel] Univ Granada, Sch Pharm, Dept Nutr & Food Sci, E-18012 Granada, Spain.
   [Ruiz, Rosario] SC Univ Clin Hosp, SAS, Biochem Lab, Granada, Spain.
   [Abuhamadah, Sawsan] Univ Jordan, Sch Pharm, Dept Pharmacol, Amman, Jordan.
   [El-Mir, Mohamad-Yehia] Univ Salamanca, Sch Pharm, Dept Physiol & Pharmacol, E-37008 Salamanca, Spain.
   [Fernandez Vazquez, Gumersindo] Carlos III Hosp, Serv Endocrinol, Madrid, Spain.
C3 University of Granada; University of Granada; University of Granada;
   University of Jordan; University of Salamanca; Hospital Carlos III
RP Agil, A (corresponding author), Univ Granada, Sch Med, Dept Pharmacol, E-18012 Granada, Spain.
EM aagil@ugr.es
RI Vázquez, Gumersindo/AAB-3317-2019; Navarro-Alarcon, Miguel/Q-4368-2019;
   Agil, Ahmad/D-9620-2014; Abuhamdah, Dr.Sawsan/F-8952-2015;
   Navarro-Alarcon, Miguel/K-6646-2014
OI Abuhamdah, Dr.Sawsan/0000-0001-5886-5742; Agil,
   Ahmad/0000-0003-0164-9648; Navarro-Alarcon, Miguel/0000-0002-3189-3310
FU CTS-109 group from the Junta de Andalucia (Spain); University of Granada
   [2010/11]; European Commission
FX This work was partially supported by CTS-109 group from the Junta de
   Andalucia (Spain) and Plan Propio Grant 2010/11 from the University of
   Granada. The authors thank Dr. Juan Moreno-Ayuso, Aureliano, and Juan
   Leiva for their technical assistance and Richard Davies for improving
   the English of the manuscript. Sawsan Abuhamadah was supported by
   Erasmus Mundus External Cooperation grant (European Commission). The
   experiment was approved by the Ethical Committee of the University of
   Granada (Granada, Spain) according to European Union guidelines.
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NR 52
TC 133
Z9 136
U1 1
U2 21
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0742-3098
EI 1600-079X
J9 J PINEAL RES
JI J. Pineal Res.
PD MAR
PY 2011
VL 50
IS 2
BP 207
EP 212
DI 10.1111/j.1600-079X.2010.00830.x
PG 6
WC Endocrinology & Metabolism; Neurosciences; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Physiology
GA 719YH
UT WOS:000287246900012
PM 21087312
DA 2025-06-11
ER

PT J
AU Hermsdorff, HHM
   Zulet, MA
   Puchau, B
   Bressan, J
   Martínez, JA
AF Miranda Hermsdorff, Helen Hermana
   Angeles Zulet, M.
   Puchau, Blanca
   Bressan, Josefina
   Alfredo Martinez, J.
TI Association of retinol-binding protein-4 with dietary selenium intake
   and other lifestyle features in young healthy women
SO NUTRITION
LA English
DT Article
DE Retinol-binding protein-4; Diet; Selenium; Lifestyle; Inflammation;
   Humans
ID DENSITY-LIPOPROTEIN CHOLESTEROL; C-REACTIVE PROTEIN; INSULIN-RESISTANCE;
   INFLAMMATORY MARKERS; METABOLIC SYNDROME; SERUM
   RETINOL-BINDING-PROTEIN-4; ENDOTHELIAL ACTIVATION; SYSTEMIC
   INFLAMMATION; PHYSICAL-ACTIVITY; ADIPOSE-TISSUE
AB Objective: This study specifically assessed plasma retinol-binding protein-4 (RBP4), an inflammatory marker, in young healthy women, with emphasis on its potential relations to dietary intake and lifestyle features.
   Methods: Seventy-four women with a mean age of 20.5 +/- 2.5 y and body mass index of 21.3 +/- 2.3 kg/m(2) were enrolled. Anthropometric, blood pressure, glucose, lipid profile, RBP4, and insulin concentrations were determined. Nutritional intakes were estimated by a validated semiquantitative food-frequency questionnaire. Physical activity and smoking status were evaluated with appropriate tools.
   Results: Regarding anthropometric and biochemical variables, only triacylglycerol concentration had a, positive and significant association with plasma RBP4 concentrations (P < 0.001). Trans fatty acid intake, vitamin A intake, and smoking time showed positive and significant correlations with RBP4 concentrations (P < 0.05). Furthermore, individuals with a higher selenium intake (P = 0.027), non-smoking participants (P = 0.032), and subjects who self-declared to practice some physical activity (P = 0.030) presented significantly lower RBP4 concentrations. Interestingly, selenium intake was inversely and significantly associated with RBP4 concentration (P = 0.018) when adjusted for smoking status, energy intake, and vitamin C, vitamin E, and zinc intakes. Plasma RBP4 concentrations were also associated with smoking status (P = 0.035), adjusted for potential confounding factors.
   Conclusion: This translational research revealed that dietary intake of a nutrient with an impact on oxidative stress such as selenium and lifestyle features such as smoking habit can modulate RBP4 concentrations. Our results suggest that plasma RBP4 values could be a valuable tool to screen potential nutrient and inflammation interactions. (C) 2009 Published by Elsevier Inc.
C1 [Miranda Hermsdorff, Helen Hermana; Angeles Zulet, M.; Puchau, Blanca; Alfredo Martinez, J.] Univ Navarra, Dept Nutr & Food Sci Physiol & Toxicol, E-31080 Pamplona, Spain.
   [Bressan, Josefina] Univ Fed Vicosa, Dept Nutr & Hlth, Vicosa, MG, Brazil.
C3 University of Navarra; Universidade Federal de Vicosa
RP Martínez, JA (corresponding author), Univ Navarra, Dept Nutr & Food Sci Physiol & Toxicol, E-31080 Pamplona, Spain.
EM jalfmtz@unav.es
RI Bressan, Josefina/A-2598-2009; Martinez Hernandez, J
   Alfredo/K-8709-2014; Zulet, M. Angeles/H-1317-2017; Hermsdorff, Helen
   Hermana Miranda/H-4525-2015
OI Bressan, Josefina/0000-0002-4993-9436; Martinez Hernandez, J
   Alfredo/0000-0001-5218-6941; Zulet, M. Angeles/0000-0002-3926-0892;
   Hermsdorff, Helen Hermana Miranda/0000-0002-4441-6572
FU Health Department of the Government of Navarra [22/2007]; Linea Especial
   about Nutrition, Obesity and Health (University of Navarra LE/97); The
   Capes Foundation; Ministry of Education of Brazil [375605-0]; IBERCAJA;
   ADA fellowships scheme of the University of Navarra
FX This work was supported by the Health Department of the Government of
   Navarra (22/2007) and by Linea Especial about Nutrition, Obesity and
   Health (University of Navarra LE/97). The Capes Foundation, Ministry of
   Education of Brazil (grant 375605-0), IBERCAJA, and ADA fellowships
   scheme of the University of Navarra also provided research grants.
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NR 63
TC 47
Z9 51
U1 0
U2 6
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0899-9007
EI 1873-1244
J9 NUTRITION
JI Nutrition
PD APR
PY 2009
VL 25
IS 4
BP 392
EP 399
DI 10.1016/j.nut.2008.09.015
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 420HV
UT WOS:000264280800004
PM 19056238
DA 2025-06-11
ER

PT J
AU James, RW
   Kalix, B
   Bioletto, S
   Brulhart-Meynet, MC
AF James, RW
   Kalix, B
   Bioletto, S
   Brulhart-Meynet, MC
TI Paraoxonase-1 promoter polymorphism C-107T and serum apolipoprotein AI
   interact to modulate serum paraoxonase-1 status
SO PHARMACOGENETICS AND GENOMICS
LA English
DT Article
DE oxidative stress; lipoprotein; atherosclerosis; polymorphism;
   organophosphate
ID HIGH-DENSITY-LIPOPROTEINS; ANTIOXIDANT ENZYME; STATUS REQUIRES; PON1
   GENE; SMOKING; ATHEROGENESIS; PHENOTYPE; DISEASE; MEN
AB Objectives The objective was to examine the hypothesis that modifications to paraoxonase-1 specific activity (SP, activity per unit mass peptide) could contribute to serum paraoxonase-1 status, a determinant of the clinical efficacy of the enzyme.
   Methods Enzyme activities and concentrations were determined in a large population (n = 912) of patients and controls. SP were subsequently examined as a function of paraoxonase-1 gene polymorphisms, plasma lipids and lipoproteins, and physiological and pathophysiological parameters.
   Results Pathophysiological parameters (diabetes, metabolic syndrome, smoking, aging) did not promote variations in paraoxonase-1 SP, whilst coronary disease lowered SP (P < 0.003). No serum lipid, apolipoprotein or lipoprotein component had an impact on specific activity, with the exception of apolipoprotein Al (P < 0.005, both substrates). The paraoxonase-1 promoter C - 107T and Q192R polymorphisms influenced SP and, together with apolipoprotein Al, were highly significant, independent determinants in regression models. There was an interaction between apolipoprotein Al and the C - 107T polymorphism, which significantly modulated SP and serum paraoxonase-1 status.
   Conclusions Enzyme inactivation giving rise to modulated activity per unit mass of peptide is not a major contributor to pathological effects of disease on serum paraoxonase-1 status. The C - 107T polymorphism and serum apolipoprotein Al have major impacts individually on SP and also provide an example of gene-environment interaction to modulate such activities. These effects accentuate the differences between - 107C and - 107T allele carriers in terms of serum paraoxonase-1 status. The data underline the complexity of the factors that determine serum paraoxonase-1 status and suggest that the latter would benefit from therapeutic modulation of serum high density lipoproteins. (c) 2005 Lippincott Williams & Wilkins.
C1 Univ Hosp, Clin Diabet Unit, Div Endocrinol Diabet & Nutr, CH-1211 Geneva, Switzerland.
C3 University of Geneva
RP Univ Hosp, Clin Diabet Unit, Div Endocrinol Diabet & Nutr, CH-1211 Geneva, Switzerland.
EM Richard.James@hcuge.ch
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NR 45
TC 5
Z9 6
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1744-6872
EI 1744-6880
J9 PHARMACOGENET GENOM
JI Pharmacogenet. Genomics
PD JUN
PY 2005
VL 15
IS 6
BP 441
EP 446
DI 10.1097/01213011-200506000-00011
PG 6
WC Biotechnology & Applied Microbiology; Genetics & Heredity; Pharmacology
   & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Genetics & Heredity; Pharmacology
   & Pharmacy
GA 939WE
UT WOS:000230102500011
PM 15900219
DA 2025-06-11
ER

PT J
AU Zhang, SY
   Lin, TT
   Bao, YC
   She, JS
   Liu, XQ
   Hu, JX
   Peng, AB
   Liu, XM
   Huang, HF
AF Zhang, Shuyu
   Lin, Tingting
   Bao, Yucheng
   She, Junsen
   Liu, Xuanqi
   Hu, Jiaxue
   Peng, Aibing
   Liu, Xinmei
   Huang, Hefeng
TI Integrated Multiomics Analyses Reveal Molecular Insights into How
   Intermittent Fasting Ameliorates Obesity and Increases Fertility in Male
   Mice
SO NUTRIENTS
LA English
DT Article
DE obesity; intermittent fasting; metabolic syndrome; male infertility;
   metabolomics; transcriptomics
ID CHAIN AMINO-ACIDS; OXIDATIVE STRESS; HEALTH; REPRODUCTION; METABOLISM;
   BENEFITS; LEPTIN; GENES
AB Background: Intermittent fasting (IF) has been increasingly recognized for its potential to mitigate obesity and diabetes. However, it remains unclear whether IF can alleviate metabolic disorder-induced male infertility. The aim of this study was to investigate the potential of IF to improve fertility outcomes in obese mice. Methods: Eight-week-old C57BL/6J mice were fed a high-fat diet (HFD) for 24 weeks to induce obesity, followed by alternate-day fasting for 6 weeks. We assessed obesity-related metabolic changes and fertility issues postintervention. Comprehensive metabolomic and transcriptomic analyses of serum and testicular samples were used to identify significant metabolic pathway modifications attributable to IF. Results: IF effectively alleviated obesity-induced male infertility, demonstrating significant attenuation of body weight gain and restoration of testicular morphology. IF normalized hypogonadism-associated testosterone depletion and improved sperm parameters. Testis multi-omics integration revealed IF-mediated reprogramming of testicular purine metabolism, coupled with coordinated regulation of glycolipid metabolism and inflammatory-immune homeostasis. Reproductive competence was enhanced as evidenced by statistically elevated successful mating rates and embryonic developmental progression. Serum metabolomics further identified metabolites involved in amino acid metabolism, glycolipid metabolism, and inflammation (e.g., methionine, BCAA, glutathione, and spermidine) may serve as potential targets for treating obesity-related metabolic disorders. Additionally, multidimensional analysis highlighted the crucial role of allantoin in alleviating obesity and related reproductive dysfunction. Conclusions: IF not only resolves obesity-induced metabolic issues but also alleviates male infertility by regulating bioactive metabolites and gene expression linked to glycolipid metabolism, energy homeostasis, and immune responses in the testis. Our study provides a theoretical basis for IF as a clinical treatment for obesity-induced male infertility.
C1 [Zhang, Shuyu; Huang, Hefeng] Shanghai Jiao Tong Univ, Int Peace Matern & Child Hlth Hosp, Shanghai Key Lab Embryo Original Dis, Sch Med, Shanghai 200030, Peoples R China.
   [Zhang, Shuyu; Liu, Xinmei; Huang, Hefeng] Shanghai Key Lab Reprod & Dev, Shanghai 200030, Peoples R China.
   [Lin, Tingting; Liu, Xuanqi; Huang, Hefeng] Zhejiang Univ, Womens Hosp, Dept Reprod Endocrinol, Key Lab Reprod Genet,Sch Med, Hangzhou 310058, Peoples R China.
   [Bao, Yucheng] Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp, Shanghai 200003, Peoples R China.
   [She, Junsen; Huang, Hefeng] Zhejiang Univ, Affiliated Hosp 4, Int Inst Med, Sch Med, Yiwu 322000, Peoples R China.
   [Hu, Jiaxue; Peng, Aibing] Zhejiang Univ, Affiliated Hosp 2, Dept Neurobiol, Sch Med, Hangzhou 310058, Peoples R China.
   [Hu, Jiaxue; Peng, Aibing] Zhejiang Univ, Affiliated Hosp 2, Dept Psychiat, Sch Med, Hangzhou 310058, Peoples R China.
   [Liu, Xinmei; Huang, Hefeng] Fudan Univ, Obstet & Gynecol Hosp, Inst Reprod & Dev, Shanghai 200030, Peoples R China.
   [Liu, Xinmei; Huang, Hefeng] Chinese Acad Med Sci, Res Units Embryo Original Dis, Shanghai 200030, Peoples R China.
C3 Shanghai Jiao Tong University; Zhejiang University; Shanghai Jiao Tong
   University; Zhejiang University; Zhejiang University; Zhejiang
   University; Fudan University; Chinese Academy of Medical Sciences -
   Peking Union Medical College
RP Huang, HF (corresponding author), Shanghai Jiao Tong Univ, Int Peace Matern & Child Hlth Hosp, Shanghai Key Lab Embryo Original Dis, Sch Med, Shanghai 200030, Peoples R China.; Liu, XM; Huang, HF (corresponding author), Shanghai Key Lab Reprod & Dev, Shanghai 200030, Peoples R China.; Huang, HF (corresponding author), Zhejiang Univ, Womens Hosp, Dept Reprod Endocrinol, Key Lab Reprod Genet,Sch Med, Hangzhou 310058, Peoples R China.; Huang, HF (corresponding author), Zhejiang Univ, Affiliated Hosp 4, Int Inst Med, Sch Med, Yiwu 322000, Peoples R China.; Liu, XM; Huang, HF (corresponding author), Fudan Univ, Obstet & Gynecol Hosp, Inst Reprod & Dev, Shanghai 200030, Peoples R China.; Liu, XM; Huang, HF (corresponding author), Chinese Acad Med Sci, Res Units Embryo Original Dis, Shanghai 200030, Peoples R China.
EM liuxinmei@fudan.edu.cn; huanghefg@sjtu.edu.cn
FU National Natural Science Foundation of China; CAMS Innovation Fund for
   Medical Sciences [2019-I2M-5-064]; Collaborative Innovation Program of
   Shanghai Municipal Health Commission [2020CXJQ01]; Key Discipline
   Construction Project [2023-2025]; Three-Year Initiative Plan for
   Strengthening Public Health System Construction in Shanghai
   [GWVI-11.1-35, SHDC2020CR1008A]; Shanghai Clinical Research Center for
   Gynecological Diseases [22MC1940200, 2022ZZ01012]; Shanghai Frontiers
   Science Research Center of Reproduction and Development;  [82088102]; 
   [82171687];  [82192873]
FX This work is supported by the National Natural Science Foundation of
   China (82088102, 82171687, 82192873), CAMS Innovation Fund for Medical
   Sciences (2019-I2M-5-064), Collaborative Innovation Program of Shanghai
   Municipal Health Commission (2020CXJQ01), Key Discipline Construction
   Project (2023-2025) of Three-Year Initiative Plan for Strengthening
   Public Health System Construction in Shanghai (GWVI-11.1-35), Clinical
   Research Plan of SHDC (SHDC2020CR1008A), Shanghai Clinical Research
   Center for Gynecological Diseases (22MC1940200), Shanghai Urogenital
   System Diseases Research Center (2022ZZ01012) and Shanghai Frontiers
   Science Research Center of Reproduction and Development.
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NR 78
TC 0
Z9 0
U1 4
U2 4
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD MAR 14
PY 2025
VL 17
IS 6
AR 1029
DI 10.3390/nu17061029
PG 25
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 0OT0V
UT WOS:001452415000001
PM 40292466
OA gold
DA 2025-06-11
ER

PT J
AU Hwang, S
   Ha, AW
AF Hwang, Sinwoo
   Ha, Ae Wha
TI Intakes of Dairy and Soy Products and 10-Year Coronary Heart Disease
   Risk in Korean Adults
SO NUTRIENTS
LA English
DT Article
DE coronary heart disease; cow's milk; dairy; soymilk; soy products; adult
ID FATTY LIVER-DISEASE; METABOLIC SYNDROME; BLOOD-PRESSURE;
   CARDIOVASCULAR-DISEASE; OXIDATIVE STRESS; MILK CONSUMPTION;
   METAANALYSIS; HEALTH; ASSOCIATION; SUPPLEMENTATION
AB Dairy and soy products are healthy food. However, studies have reported conflicting results associating their intake with coronary heart disease (CHD). Thus, this study determined the association between intake of dairy or soy products and 10-year CHD risk. Participants aged 40 similar to 69 years were grouped into those who consumed dairy products (more or less than twice a week) and those who consumed soy products (more or less than twice a week). Ten-year CHD risk (%), atherogenic index (AI), and atherogenic index of plasma (AIP) were calculated. The CHD risk, according to the level of dairy and soy product intake, was expressed as an odds ratio (OR) and a confidence interval (CI). Significant differences were observed in sex, age, education, income, and living area according to dairy intake frequencies, whereas only age showed significant differences according to soy products' intake frequencies. Relative effects of Framingham Risk Score (FRS) factors on 10-year CHD risk in Korean adults were found to be significant in the order of age, high-density lipoprotein cholesterol (HDL-C), smoking, blood total cholesterol (TC), systolic blood pressure (SBP), diabetes, and sex. Overall, participants who consumed dairy products >= 2/week had a significantly lower OR of 10-year CHD risk compared to those who consumed dairy products <2/week after adjusting for confounding factors (OR: 0.742, 95% CI: 0.619 to 0.890). Otherwise, intake of soy products >= 2/week tended to decrease the OR of 10-year CHD risk, although the decrease was not statistically significant. In conclusion, Korean adults who consumed dairy products >= 2/week had higher HDL-C and lower 10-year CHD risk than those who consumed dairy products <2/week. However, these results did not appear when consuming soy products.
C1 [Hwang, Sinwoo] Univ Calif San Diego, Shiley Eye Inst, Hamilton Glaucoma Ctr, Viterbi Family Dept Ophthalmol, La Jolla, CA 92093 USA.
   [Ha, Ae Wha] Dankook Univ, Coll Sci & Technol, Dept Food Sci & Nutr, Cheonan 31116, South Korea.
C3 University of California System; University of California San Diego;
   Dankook University
RP Ha, AW (corresponding author), Dankook Univ, Coll Sci & Technol, Dept Food Sci & Nutr, Cheonan 31116, South Korea.
EM sinwoohwang@health.ucsd.edu; aewhaha@dankook.ac.kr
RI Hwang, Sinwoo/LBI-1371-2024
OI Hwang, Sinwoo/0000-0003-0953-1097
FU DanKook University
FX This research was funded by a 2022 grant from DanKook University.
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NR 46
TC 1
Z9 1
U1 0
U2 1
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD SEP
PY 2024
VL 16
IS 17
AR 2959
DI 10.3390/nu16172959
PG 14
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA F9I4N
UT WOS:001312867300001
PM 39275274
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Kim, B
   Taniguchi, K
   Isobe, T
   Oh, S
AF Kim, Bokun
   Taniguchi, Keisuke
   Isobe, Tomonori
   Oh, Sechang
TI Triglyceride-glucose index is capable of identifying metabolically
   obese, normal-weight older individuals
SO JOURNAL OF PHYSIOLOGICAL ANTHROPOLOGY
LA English
DT Article
DE Chronic disease; Geriatric population; Metabolically obese but normal
   weight; Obesity; Triglyceride-glucose index
ID INCREASED OXIDATIVE STRESS; FATTY LIVER-DISEASE; INSULIN-RESISTANCE;
   ECONOMIC BURDEN; HEALTHY; RISK
AB Background The concept of metabolically obese, normal weight (MONW) has emerged to describe individuals with a normal body mass index (BMI) who are at a relatively high risk of chronic diseases. However, BMI itself is a suboptimal index for the assessment of the health risks associated with visceral fat. The triglyceride-glucose (TyG) index is considered to be a reliable and cost-effective marker of insulin resistance. Therefore, in the present study, we aimed to determine the TyG index cut-off values that could be used to define MONW in older people and to determine the usefulness of these values for the prediction of chronic diseases.
   Methods A total of 4,721 participants in the Korea National Health and Nutritional Examination Survey who were >= 60 years of age and did not have underweight or obesity were included. MONW was defined using the criteria for metabolic syndrome (MS), and the TyG index was calculated on the basis of the fasting plasma triglyceride and glucose concentrations. Chronic diseases, including T2DM, hypertension, and non-alcoholic fatty liver disease (NAFLD), were diagnosed.
   Results The prevalence of MS increased from the lowest to the highest TyG index tertile. The cut-off values of the TyG index for MONW were calculated as 8.88 and 8.80 for males and females, respectively. MONW, defined using these cut-off values, was associated with high odds ratios for NAFLD, T2DM, and hypertension in both males and females.
   Conclusions The TyG index cut-off values calculated in the present study can be used to discriminate individuals with MONW from other older individuals without obesity and to predict the risk of chronic diseases. These findings show that the TyG index is an effective and cost-efficient method of assessing the risk of chronic diseases in people with MONW.
C1 [Kim, Bokun] Changwon Natl Univ, Future Convergence Res Inst, Chang Won, South Korea.
   [Kim, Bokun; Taniguchi, Keisuke; Oh, Sechang] R Profess Univ Rehabil, Human Community Renovat Res Ctr, Tsuchiura, Ibaraki, Japan.
   [Taniguchi, Keisuke; Oh, Sechang] R Profess Univ Rehabil, Fac Rehabil, 2-10-35 Kohoku, Tsuchiura, Ibaraki 3000032, Japan.
   [Isobe, Tomonori; Oh, Sechang] Univ Tsukuba, Fac Med, 1-1-1 Tennodai, Tsukuba, Ibaraki 3058575, Japan.
C3 Changwon National University; University of Tsukuba
RP Oh, S (corresponding author), R Profess Univ Rehabil, Human Community Renovat Res Ctr, Tsuchiura, Ibaraki, Japan.; Oh, S (corresponding author), R Profess Univ Rehabil, Fac Rehabil, 2-10-35 Kohoku, Tsuchiura, Ibaraki 3000032, Japan.; Isobe, T; Oh, S (corresponding author), Univ Tsukuba, Fac Med, 1-1-1 Tennodai, Tsukuba, Ibaraki 3058575, Japan.
EM tiso@md.tsukuba.ac.jp; o-sechan@u.a-ru.ac.jp
OI kim, bokun/0000-0001-9553-3368
FU Ministry of Education
FX In the present study, data provided by the Korean National Health and
   Nutrition Examination Survey 2014-2018, conducted by the Korea Centers
   for Disease Control and Prevention, were analyzed. We thank Mark
   Cleasby, PhD for editing a draft of this manuscript.
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NR 31
TC 6
Z9 6
U1 2
U2 4
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1880-6805
J9 J PHYSIOL ANTHROPOL
JI J. Physiol. Anthropol.
PD FEB 3
PY 2024
VL 43
IS 1
AR 8
DI 10.1186/s40101-024-00355-6
PG 9
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA GX2J0
UT WOS:001155902800001
PM 38310267
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Lin, ZY
   Wu, SY
   Chen, Z
   Luo, WJ
   Lin, ZH
   Su, HH
   Guo, DM
AF Lin, Zeyin
   Wu, Shaoyan
   Chen, Zhe
   Luo, Weijian
   Lin, Zhihui
   Su, Honghui
   Guo, Dongming
TI Poor serum uric acid control increases risk for developing hypertension:
   a retrospective cohort study in China
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Article
DE uric acid; hypertension; blood pressure; risk factors; epidemiology
ID BLOOD-PRESSURE; INCIDENT HYPERTENSION; METABOLIC SYNDROME; OXIDATIVE
   STRESS; BASE-LINE; ADULTS; HYPERURICEMIA; ALLOPURINOL; ASSOCIATION
AB Background: Serum uric acid (SUA) has been suggested as a contributor of hypertension. However, reports on the relationship between changes in SUA and hypertension are limited. Hence, we aimed to investigate the potential impact of SUA, especially its change over time, on hypertension incidence. Methods: This dynamic cohort included 6052 participants without hypertension at baseline. Participants were categorized into six grades based on whether baseline SUA was high and whether changes in SUA progressed to hyperuricemia or decreased to normal levels. Grades 1 to 6 represented the participants' SUA control from best to worst. Logistic regression and restricted cubic spline (RCS) models were used to explore the association of the grades of SUA control and hypertension incidence. Results: During a median follow-up of 6 years, 2550 (42.1%) participants developed hypertension. After adjusting confounding factors, compared to grade 1 with the best control of SUA, the odds ratios for grades 2 to 6 with worse control were 1.347 (1.109-1.636), 1.138 (0.764-1.693), 1.552 (1.245-1.934), 1.765 (1.170-2.663), and 2.165 (1.566-2.993), respectively. RCS indicated a linear correlation between the risk of hypertension and changes in SUA, and an elevated risk in participants with baseline hyperuricemia. Subgroup analyses showed that grades of SUA control had an interaction with systolic (P = 0.003) and diastolic blood pressure (P < 0.001). Sensitivity analyses further determined the robustness of the result that participants with poor SUA control have a higher risk of developing hypertension. Conclusion: Poor SUA control, an increase in SUA over time, rises the risk of developing hypertension regardless of whether the initial SUA is normal or not. Initial hyperuricemia will exacerbate this risk. Effective SUA control should be an important measure for primary prevention of hypertension.
C1 [Lin, Zeyin] Shantou Univ, Affiliated Hosp 1, Dept Ultrasound, Med Coll, Shantou, Peoples R China.
   [Wu, Shaoyan; Chen, Zhe; Luo, Weijian; Lin, Zhihui; Su, Honghui; Guo, Dongming] Shantou Univ, Affiliated Hosp 2, Dept Intervent Ultrasound, Med Coll, Shantou, Peoples R China.
C3 Shantou University; Shantou University
RP Guo, DM (corresponding author), Shantou Univ, Affiliated Hosp 2, Dept Intervent Ultrasound, Med Coll, Shantou, Peoples R China.
EM kogoming@163.com
RI lin, zhihui/GOH-2451-2022
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NR 34
TC 3
Z9 3
U1 2
U2 4
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD JAN 31
PY 2024
VL 15
AR 1343998
DI 10.3389/fendo.2024.1343998
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA HQ9S3
UT WOS:001161095700001
PM 38356958
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Pantiya, P
   Thonusin, C
   Sumneang, N
   Ongnok, B
   Chunchai, T
   Kerdphoo, S
   Jaiwongkam, T
   Arunsak, B
   Siri-Angkul, N
   Sriwichaiin, S
   Chattipakorn, N
   Chattipakorn, SC
AF Pantiya, Patcharapong
   Thonusin, Chanisa
   Sumneang, Natticha
   Ongnok, Benjamin
   Chunchai, Titikorn
   Kerdphoo, Sasiwan
   Jaiwongkam, Thidarat
   Arunsak, Busarin
   Siri-Angkul, Natthaphat
   Sriwichaiin, Sirawit
   Chattipakorn, Nipon
   Chattipakorn, Siriporn C.
TI High Cardiorespiratory Fitness Protects against Molecular Impairments of
   Metabolism, Heart, and Brain with Higher Efficacy in Obesity-Induced
   Premature Aging
SO ENDOCRINOLOGY AND METABOLISM
LA English
DT Article
DE Cardiorespiratory fitness; Metabolic syndrome; Cardiovascular diseases;
   Neurodegenerative diseases; Obesity; Aging; premature
ID INTRINSIC AEROBIC CAPACITY; SKELETAL-MUSCLE; IMPACTS SUSCEPTIBILITY;
   ARTIFICIAL SELECTION; RUNNING CAPACITY; CARDIAC-FUNCTION; MORTALITY;
   EXERCISE; PREDICTOR; ENDURANCE
AB Background: High cardiorespiratory fitness (CRF) protects against age-related diseases. However, the mechanisms mediating the protective effect of high intrinsic CRF against metabolic, cardiac, and brain impairments in non-obese versus obese conditions remain incompletely understood. We aimed to identify the mechanisms through which high intrinsic CRF protects against metabolic, cardiac, and brain impairments in non-obese versus obese untrained rats. Methods: Seven-week-old male Wistar rats were divided into two groups (n=8 per group) to receive either a normal diet or a high -fat diet (HFD). At weeks 12 and 28, CRF, carbohydrate and fatty acid oxidation, cardiac function, and metabolic parameters were evaluated. At week 28, behavior tests were performed. At the end of week 28, rats were euthanized to collect heart and brain samples for molecular studies. Results: The obese rats exhibited higher values for aging-related parameters than the non-obese rats, indicating that they experienced obesity-induced premature aging. High baseline CRF levels were positively correlated with several favorable metabolic, cardiac, and brain parameters at follow-up. Specifically, the protective effects of high CRF against metabolic, cardiac, and brain impairments were mediated by the modulation of body weight and composition, the lipid profile, substrate oxidation, mitochondrial function, insulin signaling, autophagy, apoptosis, inflammation, oxidative stress, cardiac function, neurogenesis, blood-brain barrier, synaptic function, accumulation of Alzheimer's disease-related proteins, and cognition. Interestingly, this effect was more obvious in HFD-fed rats. Conclusion: The protective effect of high CRF is mediated by the modulation of several mechanisms. These effects exhibit greater efficacy under conditions of obesity-induced premature aging.
C1 [Pantiya, Patcharapong; Thonusin, Chanisa; Sumneang, Natticha; Ongnok, Benjamin; Chunchai, Titikorn; Kerdphoo, Sasiwan; Jaiwongkam, Thidarat; Arunsak, Busarin; Siri-Angkul, Natthaphat; Sriwichaiin, Sirawit; Chattipakorn, Nipon; Chattipakorn, Siriporn C.] Chiang Mai Univ, Fac Med, Cardiac Electrophysiol Res & Training Ctr, Neurophysiol Unit, Chiang Mai, Thailand.
   [Pantiya, Patcharapong; Thonusin, Chanisa; Sumneang, Natticha; Ongnok, Benjamin; Siri-Angkul, Natthaphat; Sriwichaiin, Sirawit; Chattipakorn, Nipon; Chattipakorn, Siriporn C.] Chiang Mai Univ, Fac Med, Dept Physiol, Cardiac Electrophysiol Unit, Chiang Mai, Thailand.
   [Pantiya, Patcharapong; Thonusin, Chanisa; Sumneang, Natticha; Ongnok, Benjamin; Chunchai, Titikorn; Kerdphoo, Sasiwan; Jaiwongkam, Thidarat; Arunsak, Busarin; Siri-Angkul, Natthaphat; Sriwichaiin, Sirawit; Chattipakorn, Nipon] Chiang Mai Univ, Ctr Excellence Cardiac Electrophysiol Res, Chiang Mai, Thailand.
   [Chattipakorn, Siriporn C.] Chiang Mai Univ, Fac Dent, Dept Oral Biol & Diagnost Sci, Chiang Mai, Thailand.
   [Chattipakorn, Siriporn C.] Chiang Mai Univ, Fac Med, Neurophysiol Unit, Cardiac Electrophysiol Res & Training Ctr, 110 Intawaroros Rd, Chiang Mai 50200, Thailand.
C3 Chiang Mai University; Chiang Mai University; Chiang Mai University;
   Chiang Mai University; Chiang Mai University
RP Chattipakorn, SC (corresponding author), Chiang Mai Univ, Fac Med, Neurophysiol Unit, Cardiac Electrophysiol Res & Training Ctr, 110 Intawaroros Rd, Chiang Mai 50200, Thailand.
EM siriporn.c@cmu.ac.th
RI Sumneang, Natticha/IST-7609-2023; Chattipakorn, Nipon/AAJ-4049-2021
OI Chattipakorn, Siriporn/0000-0003-1677-7052; Siri-Angkul,
   Natthaphat/0000-0002-2776-3759
FU Faculty of Medicine Chiang Mai University [060-2564]; Senior Research
   Scholar Grant from the National Research Council of Thailand; Chiang Mai
   University, Thailand; Royal Golden Jubilee Ph.D. program from the
   National Research Council of Thailand [N41A650088]; Research Grant for
   New Scholar from the National Research Council of Thailand [RGNS
   64-059]; Royal Golden Jubilee Ph.D. program [PHD/0106/2561]; NSTDA
   Research Chair Grant from the National Science and Technology
   Development Agency Thailand; Chiang Mai University Center of Excellence
   Award; Thailand Science Research and Innovation grant [DBG6280006]
FX This study was supported by the Faculty of Medicine Chiang Mai
   University Endowment Fund: 060-2564 (Chanisa Thonusin); a Senior
   Research Scholar Grant from the National Research Council of Thailand
   (Siriporn C. Chattipakorn); a Teaching Assistant and Research Assistant
   (TARA) Scholarship, Chiang Mai University, Thailand (Patcharapong
   Pantiya); the Royal Golden Jubilee Ph.D. program from the National
   Research Council of Thailand (N41A650088: Patcharapong Pantiya &
   Siriporn C. Chattipakorn); the Research Grant for New Scholar from the
   National Research Council of Thailand (RGNS 64-059 Chanisa Thonusin);
   the Royal Golden Jubilee Ph.D. program (PHD/0106/2561 Benjamin Ongnok &
   Siriporn C. Chattipakorn); the NSTDA Research Chair Grant from the
   National Science and Technology Development Agency Thailand (Nipon
   Chattipakorn); a Chiang Mai University Center of Excellence Award (Nipon
   Chattipakorn); and the Thailand Science Research and Innovation grant
   DBG6280006 (Nipon Chattipakorn).
CR Bonomini F, 2015, AGING DIS, V6, P109, DOI 10.14336/AD.2014.0305
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NR 31
TC 3
Z9 3
U1 0
U2 4
PU KOREAN ENDOCRINE SOC
PI SEOUL
PA 101-2503, 109 MAPO-DAERO, MAPO-GU, SEOUL, 04146, SOUTH KOREA
SN 2093-596X
EI 2093-5978
J9 ENDOCRINOL METAB
JI Endocrinol. Metab.
PD AUG
PY 2022
VL 37
IS 4
BP 630
EP 640
DI 10.3803/EnM.2022.1430
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 5S3QE
UT WOS:000875108100008
PM 35927067
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Zhang, Q
   Li, XM
   Qiao, S
   Liu, SF
   Zhou, YJ
   Shen, ZY
AF Zhang, Quan
   Li, Xiaoming
   Qiao, Shan
   Liu, Shuaifeng
   Zhou, Yuejiao
   Shen, Zhiyong
TI The relationship of hair glucocorticoid levels to immunological and
   virological outcomes in a large cohort of combination antiretroviral
   therapy treated people living with HIV
SO BMC INFECTIOUS DISEASES
LA English
DT Article
DE Hair cortisol; Hair cortisone; CD4 count; HIV viral load; People living
   with HIV
ID CORTISOL-LEVELS; DISEASE PROGRESSION; METABOLIC SYNDROME;
   HOMOSEXUAL-MEN; SERUM CORTISOL; INFECTION; STRESS; SOCIETY; ENDOCRINE;
   SYMPTOMS
AB Background Existing literature mostly investigated the relationship of acute or short-term glucocorticoid exposure to HIV disease progression using cortisol levels in serum, saliva, or urine. Data are limited on the relationship of long-term glucocorticoid exposure to HIV disease progression. This study examined whether hair glucocorticoid levels, novel retrospective indicators of long-term glucocorticoid exposure, are associated with two common indicators of HIV disease progression (CD4 count and HIV viral load) among a large cohort of combination antiretroviral therapy treated Chinese people living with HIV (PLHIV). Methods A total of 1198 treated PLHIV provided hair samples for glucocorticoid (cortisol and cortisone) assay and completed a survey assessing sociodemographic, lifestyle, and HIV-related characteristics. Meanwhile, CD4 count and HIV viral load were retrieved from their medical records. Spearman correlation was used to examine the associations of hair cortisol and cortisone levels to continuous CD4 count and HIV viral load. Multivariate logistic regression was used to predict CD4 count < 500 cells/mm(3). Results Both hair cortisol and cortisone levels were negatively associated with CD4 count but not with HIV viral load. The odds ratio for CD4 count < 500 cells/mm(3) was 1.41 [95% CI 0.99-2.00] and 2.15 [95% CI 1.51-3.05] for those with hair cortisol and cortisone levels in the highest quartile compared to the lowest when controlling for sociodemographic, lifestyle, HIV-related covariates, and HIV viral load. Conclusion Hair glucocorticoid levels were associated with CD4 count but not viral load in treated Chinese PLHIV. Our data furtherly supported the hypothesis that elevated glucocorticoid levels are associated with the lower CD4 count.
C1 [Zhang, Quan; Li, Xiaoming; Qiao, Shan] Univ South Carolina, Arnold Sch Publ Hlth, South Carolina SmartState Ctr Healthcare Qual CHQ, Columbia, SC 29208 USA.
   [Zhang, Quan] Univ Tennessee, Hlth Sci Ctr, Coll Hlth Profess, Integrat Muscle Biol Lab,Div Rehabil Sci, Canc Res Bldg,Room 335,195 Manassas St, Memphis, TN 38103 USA.
   [Liu, Shuaifeng; Zhou, Yuejiao; Shen, Zhiyong] Guangxi Zhuang Autonomous Reg Ctr Dis Control & P, 18 Jinzhou Rd, Nanning 530028, Guangxi, Peoples R China.
C3 University of South Carolina System; University of South Carolina
   Columbia; University of Tennessee System; University of Tennessee Health
   Science Center
RP Zhang, Q (corresponding author), Univ South Carolina, Arnold Sch Publ Hlth, South Carolina SmartState Ctr Healthcare Qual CHQ, Columbia, SC 29208 USA.; Zhang, Q (corresponding author), Univ Tennessee, Hlth Sci Ctr, Coll Hlth Profess, Integrat Muscle Biol Lab,Div Rehabil Sci, Canc Res Bldg,Room 335,195 Manassas St, Memphis, TN 38103 USA.; Shen, ZY (corresponding author), Guangxi Zhuang Autonomous Reg Ctr Dis Control & P, 18 Jinzhou Rd, Nanning 530028, Guangxi, Peoples R China.
EM qzhang49@uthsc.edu; shenzhiyong99999@sina.com
RI Li, Huihuang/GNM-7727-2022; Zhang, Quan/ABF-9541-2020
OI Zhang, Quan/0000-0001-6028-6977
FU National Institutes of Health [R01MH0112376]; National Nature Science
   Foundation of China [81761128004]; National Institute of Mental Health
   [R01MH112376] Funding Source: NIH RePORTER
FX This study was supported by the National Institutes of Health (Grant
   number R01MH0112376) and the National Nature Science Foundation of China
   (Grant number 81761128004). The funding body had no role in the data
   collection, analysis, interpretation of the data, and writing of the
   manuscript.
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NR 57
TC 2
Z9 2
U1 0
U2 8
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2334
J9 BMC INFECT DIS
JI BMC Infect. Dis.
PD MAR 20
PY 2022
VL 22
IS 1
AR 268
DI 10.1186/s12879-022-07257-x
PG 8
WC Infectious Diseases
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Infectious Diseases
GA ZX1AJ
UT WOS:000771632500003
PM 35307019
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Tognocchi, M
   Conte, M
   Testai, L
   Martucci, M
   Serra, A
   Salvioli, S
   Calderone, V
   Mele, M
   Conte, G
AF Tognocchi, Monica
   Conte, Maria
   Testai, Lara
   Martucci, Morena
   Serra, Andrea
   Salvioli, Stefano
   Calderone, Vincenzo
   Mele, Marcello
   Conte, Giuseppe
TI Supplementation of Enriched Polyunsaturated Fatty Acids and CLA Cheese
   on High Fat Diet: Effects on Lipid Metabolism and Fat Profile
SO FOODS
LA English
DT Article
DE cheese; high-fat diet; lipid metabolism; CLA; PUFA omega-3;
   inflammation; obesity; metabolic syndrome
ID GENE-EXPRESSION; TRIGLYCERIDE SYNTHESIS; INSULIN-RESISTANCE; OXIDATIVE
   STRESS; ADIPOSE-TISSUE; MICE; INFLAMMATION; GLUCOSE; OVEREXPRESSION;
   ACCUMULATION
AB Epidemiological studies have demonstrated a positive relationship between dietary fat intake and the onset of several metabolic diseases. This association is particularly evident in a diet rich in saturated fatty acids, typical of animal foods, such as dairy products. However, these foods are the main source of fatty acids with a proven nutraceutical effect, such as the omega-3 fatty acid alpha-linolenic acid (ALA) and the conjugated linoleic acid (CLA), which have demonstrated important roles in the prevention of various diseases. In the present study, the effect of a supplementation with cheese enriched with omega-3 fatty acids and CLA on the metabolism and lipid profiles of C57bl/6 mice was evaluated. In particular, the analyses were conducted on different tissues, such as liver, muscle, adipose tissue and brain, known for their susceptibility to the effects of dietary fats. Supplementing cheese enriched in CLA and omega-3 fats reduced the level of saturated fat and increased the content of CLA and ALA in all tissues considered, except for the brain. Furthermore, the consumption of this cheese resulted in a tissue-specific response in the expression levels of genes involved in lipid and mitochondrial metabolism. As regards genes involved in the inflammatory response, the consumption of enriched cheese resulted in a reduction in the expression of inflammatory genes in all tissues analyzed. Considering the effects that chronic inflammation associated with a high-calorie and high-fat diet (meta-inflammation) or aging (inflammaging) has on the onset of chronic degenerative diseases, these data could be of great interest as they indicate the feasibility of modulating inflammation (thus avoiding/delaying these pathologies) with a nutritional and non-pharmacological intervention.
C1 [Tognocchi, Monica; Serra, Andrea; Mele, Marcello; Conte, Giuseppe] Univ Pisa, Dept Agr Food & Environm, Via Borghetto 80, I-56124 Pisa, Italy.
   [Conte, Maria; Martucci, Morena; Salvioli, Stefano] Univ Bologna, Dipartimento Med Specialist Diagnost & Sperimenta, I-40126 Bologna, Italy.
   [Testai, Lara; Calderone, Vincenzo] Univ Pisa, Dipartimento Farm, I-56126 Pisa, Italy.
   [Testai, Lara; Serra, Andrea; Calderone, Vincenzo; Mele, Marcello; Conte, Giuseppe] Univ Pisa, Res Ctr Nutraceut & Food Hlth, Via Borghetto 80, I-56124 Pisa, Italy.
C3 University of Pisa; University of Bologna; University of Pisa;
   University of Pisa
RP Conte, G (corresponding author), Univ Pisa, Dept Agr Food & Environm, Via Borghetto 80, I-56124 Pisa, Italy.; Conte, G (corresponding author), Univ Pisa, Res Ctr Nutraceut & Food Hlth, Via Borghetto 80, I-56124 Pisa, Italy.
EM moni.tognocchi@gmail.com; andrea.serra@unipi.it; lara.testai@unipi.it;
   marcello.mele@unipi.it; andrea.serra@unipi.it;
   stefano.salvioli@unibo.it; vincenzo.calderone@unipi.it;
   marcello.mele@unipi.it; giuseppe.conte@unipi.it
RI Conte, Maria/LYO-3374-2024; Mele, Marcello/AAR-8847-2020; Serra,
   Andrea/AFO-7144-2022; Mele, Marcello/I-5071-2014; CALDERONE,
   VINCENZO/L-9288-2015
OI Tognocchi, Monica/0009-0004-2288-4334; Conte,
   Giuseppe/0000-0002-7257-4762; Serra, Andrea/0000-0001-7728-3430; Conte,
   Maria/0000-0002-4621-9898; testai, lara/0000-0003-2431-6248; Mele,
   Marcello/0000-0002-7896-012X; CALDERONE, VINCENZO/0000-0002-1441-5421
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NR 77
TC 4
Z9 5
U1 0
U2 22
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2304-8158
J9 FOODS
JI Foods
PD FEB
PY 2022
VL 11
IS 3
AR 398
DI 10.3390/foods11030398
PG 21
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA ZH3XP
UT WOS:000760875400001
PM 35159548
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Ordonez-Diaz, MD
   Gil-Campos, M
   Flores-Rojas, K
   Munoz-Villanueva, MC
   Mesa, MD
   de la Torre-aguilar, MJ
   Gil, A
   Perez-Navero, JL
AF Ordonez-Diaz, Maria Dolores
   Gil-Campos, Mercedes
   Flores-Rojas, Katherine
   Munoz-Villanueva, Maria Carmen
   Mesa, Maria Dolores
   de la Torre-aguilar, Maria Jose
   Gil, Angel
   Perez-Navero, Juan Luis
TI Impaired Antioxidant Defence Status Is Associated With
   Metabolic-Inflammatory Risk Factors in Preterm Children With
   Extrauterine Growth Restriction: The BIORICA Cohort Study
SO FRONTIERS IN NUTRITION
LA English
DT Article
DE prematurity; extrauterine growth restriction (EUGR); antioxidants;
   catalase (CAT); glutathione peroxidase (GPx); glutathione reductase
   (GR); superoxide dismutase (SOD); children
ID FOR-GESTATIONAL-AGE; OXIDATIVE STRESS MARKERS; SUPEROXIDE DISMUTASE;
   PARENTERAL-NUTRITION; BORN SMALL; SYSTEM; TERM; NEWBORNS; OBESITY; BIRTH
AB Introduction: An impaired antioxidant status has been described during foetal growth restriction (FGR). Similarly, the antioxidant defence system can be compromised in preterm children with extrauterine growth restriction (EUGR). The aim of this prospective study was to evaluate the antioxidant status in prepubertal children with a history of prematurity without FGR, with and without EUGR, compared to a healthy group.Methods: In total, 211 children were recruited and classified into three groups: 38 with a history of prematurity and EUGR; 50 with a history of prematurity and adequate extrauterine growth (AEUG); and 123 control children born at term. Catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx) and glutathione reductase (GR) activities were assessed in lysed erythrocytes with spectrophotometric methods. Plasma levels of the antioxidants alpha-tocopherol, retinol and beta-carotene were determined through solvent extraction and ultra-high-pressure liquid chromatography coupled to mass spectrometry.Results: Children with the antecedent of EUGR and prematurity had lower CAT activity than the other two groups and lower GPx activity than the control children. Lower SOD, GPx and GR activities were observed in the AEUG group compared to the controls. However, higher concentrations of alpha-tocopherol and beta-carotene were found in the EUGR group compared to the other groups; retinol levels were also higher in EUGR than in AEUG children. In EUGR and AEUG children, enzymatic antioxidant activities and plasma antioxidants were associated with metabolic syndrome components and pro-inflammatory biomarkers.Conclusions: This study reveals, for the first time, that the EUGR condition and prematurity appear to be linked to an impairment of the antioxidant defence status, which might condition an increased risk of adverse metabolic outcomes later in life.
C1 [Ordonez-Diaz, Maria Dolores] Univ Cordoba, Maimonides Biomed Res Inst Cordoba, Reina Sofia Hosp, Unit Neonatol,Dept Paediat, Cordoba, Spain.
   [Gil-Campos, Mercedes; Flores-Rojas, Katherine; de la Torre-aguilar, Maria Jose; Perez-Navero, Juan Luis] Univ Cordoba, Reina Sofia Univ Hosp, Maimonides Biomed Res Inst Cordoba, Unit Metab & Paediat Res, Cordoba, Spain.
   [Gil-Campos, Mercedes; Flores-Rojas, Katherine; Gil, Angel] Carlos III Hlth Inst, Biomed Res Ctr, Pathophysiol Obes & Nutr, Madrid, Spain.
   [Munoz-Villanueva, Maria Carmen] Maimonides Biomed Res Inst Cordoba, Unit Methodol Invest, Cordoba, Spain.
   [Mesa, Maria Dolores; Gil, Angel] Univ Granada, Inst Nutr & Food Technol, Ctr Biomed Res, Dept Biochem & Mol Biol 2, Granada, Spain.
   [Mesa, Maria Dolores; Gil, Angel] Granada Biosanitary Res Inst Ibs Granada, Granada, Spain.
   [Perez-Navero, Juan Luis] Carlos III Hlth Inst, Biomed Res Ctr Rare Dis CIBERER, Madrid, Spain.
C3 Universidad de Cordoba; Universidad de Cordoba; University of Granada;
   CIBER - Centro de Investigacion Biomedica en Red; CIBERER
RP Gil-Campos, M (corresponding author), Univ Cordoba, Reina Sofia Univ Hosp, Maimonides Biomed Res Inst Cordoba, Unit Metab & Paediat Res, Cordoba, Spain.; Gil-Campos, M (corresponding author), Carlos III Hlth Inst, Biomed Res Ctr, Pathophysiol Obes & Nutr, Madrid, Spain.
EM mercedes_gil_campos@yahoo.es
RI ; Mesa, Maria/M-3523-2014; Gil, Angel/L-2275-2014
OI Gil-Campos, Mercedes/0000-0002-9007-0242; Mesa,
   Maria/0000-0003-4079-6464; Gil, Angel/0000-0001-7663-0939
FU Plan Nacional de Investigacion Cientifica, Desarrollo e Innovacion
   Tecnologica; Instituto de Salud Carlos III-Fondo de Investigacion
   Sanitaria Project Spanish Ministry of Health and Consumer Affairs
   [PI13/01245]; Consejeria de Innovacion y Ciencia, Junta de Andalucia
   [PI-0480-2012]; Research Plan of the ViceRectorate of Research and
   Transfer of the University of Granada, Spain; Biomedicine Program at the
   University of Cordoba, Spain; Maternal-Infant and Developmental Health
   Network (SAMID); RETICS Carlos III Health Institute (ISCIII), Madrid,
   Spain [Red SAMID RD12/0026/0015]
FX This study was funded by the Plan Nacional de Investigacion Cientifica,
   Desarrollo e Innovacion Tecnologica (Ithorn DthornI), Instituto de Salud
   Carlos III-Fondo de Investigacion Sanitaria Project No. PI13/01245 from
   the Spanish Ministry of Health and Consumer Affairs and co-financed by
   the Consejeria de Innovacion y Ciencia, Junta de Andalucia,
   PI-0480-2012, Spain. AG was funded by the Research Plan of the
   ViceRectorate of Research and Transfer of the University of Granada,
   Spain. This paper will be included in MO-D's doctorate under the
   Biomedicine Program at the University of Cordoba, Spain. The funding
   bodies did not partake in the design, collection, analyses, or
   interpretation of the data or in writing the manuscript. Maternal-Infant
   and Developmental Health Network (SAMID), RETICS Carlos III Health
   Institute (ISCIII), Madrid, Spain (Red SAMID RD12/0026/0015).
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NR 64
TC 4
Z9 4
U1 0
U2 7
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD DEC 21
PY 2021
VL 8
AR 793862
DI 10.3389/fnut.2021.793862
PG 13
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA YB5VW
UT WOS:000739080700001
PM 34993223
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Portero, V
   Nicol, T
   Podliesna, S
   Marchal, GA
   Baartscheer, A
   Casini, S
   Tadros, R
   Treur, JL
   Tanck, MWT
   Cox, IJ
   Probert, F
   Hough, TA
   Falcone, S
   Beekman, L
   Müller-Nurasyid, M
   Kastenmüller, G
   Gieger, C
   Peters, A
   Kääb, S
   Sinner, MF
   Blease, A
   Verkerk, AO
   Bezzina, CR
   Potter, PK
   Remme, CA
AF Portero, Vincent
   Nicol, Thomas
   Podliesna, Svitlana
   Marchal, Gerard A.
   Baartscheer, Antonius
   Casini, Simona
   Tadros, Rafik
   Treur, Jorien L.
   Tanck, Michael W. T.
   Cox, I. Jane
   Probert, Fay
   Hough, Tertius A.
   Falcone, Sara
   Beekman, Leander
   Muller-Nurasyid, Martina
   Kastenmuller, Gabi
   Gieger, Christian
   Peters, Annette
   Kaab, Stefan
   Sinner, Moritz F.
   Blease, Andrew
   Verkerk, Arie O.
   Bezzina, Connie R.
   Potter, Paul K.
   Remme, Carol Ann
TI Chronically elevated branched chain amino acid levels are pro-arrhythmic
SO CARDIOVASCULAR RESEARCH
LA English
DT Article
DE Arrhythmia; Electrophysiology; Sudden death; Metabolism; BCAA
ID CELL-DERIVED CARDIOMYOCYTES; SUDDEN CARDIAC DEATH; LATE SODIUM CURRENT;
   ATRIAL-FIBRILLATION; OXIDATIVE STRESS; ENU MUTAGENESIS; SEX-DIFFERENCES;
   CALCIUM; AMINOTRANSFERASE; MECHANISMS
AB Aims Cardiac arrhythmias comprise a major health and economic burden and are associated with significant morbidity and mortality, including cardiac failure, stroke, and sudden cardiac death (SCD). Development of efficient preventive and therapeutic strategies is hampered by incomplete knowledge of disease mechanisms and pathways. Our aim is to identify novel mechanisms underlying cardiac arrhythmia and SCD using an unbiased approach. Methods and results We employed a phenotype-driven N-ethyl-N-nitrosourea mutagenesis screen and identified a mouse line with a high incidence of sudden death at young age (6-9 weeks) in the absence of prior symptoms. Affected mice were found to be homozygous for the nonsense mutation Bcat2(p.Q300*/p.Q300*) in the Bcat2 gene encoding branched chain amino acid transaminase 2. At the age of 4-5 weeks, Bcat2(p.Q300*/p.Q300*) mice displayed drastic increase of plasma levels of branch chain amino acids (BCAAs-leucine, isoleucine, valine) due to the incomplete catabolism of BCAAs, in addition to inducible arrhythmias ex vivo as well as cardiac conduction and repolarization disturbances. In line with these findings, plasma BCAA levels were positively correlated to electrocardiogram indices of conduction and repolarization in the German community-based KORA F4 Study. Isolated cardiomyocytes from Bcat2(p.Q300*/p.Q300*) mice revealed action potential (AP) prolongation, pro-arrhythmic events (early and late afterdepolarizations, triggered APs), and dysregulated calcium homeostasis. Incubation of human pluripotent stem cell-derived cardiomyocytes with elevated concentration of BCAAs induced similar calcium dysregulation and pro-arrhythmic events which were prevented by rapamycin, demonstrating the crucial involvement of mTOR pathway activation. Conclusions Our findings identify for the first time a causative link between elevated BCAAs and arrhythmia, which has implications for arrhythmogenesis in conditions associated with BCAA metabolism dysregulation such as diabetes, metabolic syndrome, and heart failure.
C1 [Portero, Vincent; Podliesna, Svitlana; Marchal, Gerard A.; Baartscheer, Antonius; Casini, Simona; Beekman, Leander; Verkerk, Arie O.; Bezzina, Connie R.; Remme, Carol Ann] Amsterdam UMC, Dept Clin & Expt Cardiol, Locat AMC, Heart Ctr, Room K2-104-2,Meibergdreef 9,POB 22700, NL-1100 DE Amsterdam, Netherlands.
   [Nicol, Thomas; Hough, Tertius A.; Falcone, Sara; Blease, Andrew] MRC Harwell Inst, Mammalian Genet Unit, Harwell, Oxon, England.
   [Tadros, Rafik] Univ Montreal, Montreal Heart Inst, Cardiovasc Genet Ctr, Montreal, PQ, Canada.
   [Tadros, Rafik] Univ Montreal, Fac Med, Montreal, PQ, Canada.
   [Treur, Jorien L.] Amsterdam UMC, Locat AMC, Dept Psychiat, Amsterdam, Netherlands.
   [Tanck, Michael W. T.] Univ Amsterdam, Amsterdam UMC, Dept Epidemiol & Data Sci, Amsterdam Publ Hlth APH, Amsterdam, Netherlands.
   [Cox, I. Jane] Fdn Liver Res, Inst Hepatol London, London, England.
   [Cox, I. Jane] Kings Coll London, Fac Life Sci & Med, London, England.
   [Probert, Fay] Univ Oxford, Dept Chem, Oxford, England.
   [Muller-Nurasyid, Martina; Gieger, Christian] German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Res Unit Mol Epidemiol, Neuherberg, Germany.
   [Muller-Nurasyid, Martina] Ludwig Maximilians Univ LMU Munich, Fac Med, IBE, Munich, Germany.
   [Muller-Nurasyid, Martina] Johannes Gutenberg Univ Mainz, Univ Med Ctr, Inst Med Biostat Epidemiol & Informat IMBEI, Mainz, Germany.
   [Kastenmuller, Gabi] German Res Ctr Environm Hlth, Inst Bioinformat & Syst Biol, Helmholtz Zentrum Munchen, Neuherberg, Germany.
   [Kastenmuller, Gabi; Gieger, Christian] German Ctr Diabet Res DZD, Neuherberg, Germany.
   [Gieger, Christian] German Res Ctr Environm Hlth, Inst Human Genet, Helmholtz Zentrum Munchen, Neuherberg, Germany.
   [Gieger, Christian; Peters, Annette] German Res Ctr Environm Hlth, Inst Epidemiol 2, Helmholtz Zentrum Munchen, Neuherberg, Germany.
   [Gieger, Christian; Peters, Annette; Kaab, Stefan; Sinner, Moritz F.] German Ctr Cardiovasc Res DZHK, Partner Site Munich Heart Alliance, Munich, Germany.
   [Kaab, Stefan; Sinner, Moritz F.] Ludwig Maximilians Univ Munchen, Univ Hosp, Dept Med Cardiol 1, Munich, Germany.
   [Potter, Paul K.] Oxford Brookes Univ, Fac Hlth & Life Sci, Dept Biol & Med Sci, Oxford, England.
C3 University of Amsterdam; MRC Harwell; Universite de Montreal; Universite
   de Montreal; Vrije Universiteit Amsterdam; University of Amsterdam;
   University of Amsterdam; University of London; University College
   London; University of London; King's College London; University of
   Oxford; Helmholtz Association; Helmholtz-Center Munich - German Research
   Center for Environmental Health; University of Munich; Johannes
   Gutenberg University of Mainz; Helmholtz Association; Helmholtz-Center
   Munich - German Research Center for Environmental Health; German Center
   for Diabetes Research (DZD); Helmholtz Association; Helmholtz-Center
   Munich - German Research Center for Environmental Health; Helmholtz
   Association; Helmholtz-Center Munich - German Research Center for
   Environmental Health; German Centre for Cardiovascular Research; Munich
   Heart Alliance; University of Munich; Oxford Brookes University
RP Portero, V; Remme, CA (corresponding author), Amsterdam UMC, Dept Clin & Expt Cardiol, Locat AMC, Heart Ctr, Room K2-104-2,Meibergdreef 9,POB 22700, NL-1100 DE Amsterdam, Netherlands.
EM vincent.portero@hotmail.fr; c.a.remme@amsterdamumc.nl
RI Tanck, Michael/AFY-1138-2022; Marchal, Gerard A/HNS-1995-2023; Sinner,
   Moritz/AAW-5043-2020; Kastenmüller, Gabi/ABF-5987-2020; Potter,
   Paul/GWU-6398-2022; Verkerk, Arie/HQZ-9694-2023; Gieger,
   Christian/A-3083-2013; Muller-Nurasyid, Martina/I-8735-2018; Peters,
   Annette/A-6117-2011
OI Cox, Isobel Jane/0000-0002-9828-7235; Muller-Nurasyid,
   Martina/0000-0003-3793-5910; Verkerk, Arie/0000-0003-2140-834X; Portero,
   Vincent/0000-0002-7221-859X; Tadros, Rafik/0000-0002-1472-0258; Peters,
   Annette/0000-0001-6645-0985; Potter, Paul/0000-0003-2689-2361; Treur,
   Jorien/0000-0003-4370-3390; Marchal, Gerard A/0000-0002-7353-0235;
   Blease, Andrew/0000-0001-5784-7016; Tanck, Michael/0000-0001-9828-4459;
   Casini, Simona/0000-0002-2672-2779; Nicol, Thomas/0000-0002-9636-9026;
   Probert, Fay/0000-0002-8580-2023; Remme, Carol Ann/0000-0003-0095-0084
FU Dutch Heart Foundation (CVON-PREDICT2); Dutch Heart Foundation
   (CVON-eDETECT); Netherlands Organization for Scientific Research
   [451001031, 016.150.610, 91714371]; Philippa and Marvin Carsley Chair in
   cardiology; Fondation Leducq Transatlantic Network of Excellence;
   Medical Research Council, UK [MCU142684172, MC_PC_13045]; Brain &
   Behavior Research Foundation; MRC [MC_PC_13045] Funding Source: UKRI
FX This work was supported by grants from the Dutch Heart Foundation
   (CVON-PREDICT2 and CVON-eDETECT; to C.R.B. and C.A.R.), the Netherlands
   Organization for Scientific Research (Off Road fellowship, 451001031, to
   V.P.; VICI fellowship, 016.150.610, to C.R.B.; VIDI fellowship,
   91714371, to C.A.R.), the Philippa and Marvin Carsley Chair in
   cardiology (R.T.), a Fondation Leducq Transatlantic Network of
   Excellence (C.R.B. and C.A.R.) and by the Medical Research Council, UK
   (MCU142684172 and MC_PC_13045, P.K.P.). R.T. is a clinical research
   scholar of Fonds de recherche du Que ' bec-Sante '. J.L.T. is supported
   by a 2019NARSAD Young Investigator Grant from the Brain & Behavior
   Research Foundation.
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NR 52
TC 34
Z9 36
U1 0
U2 15
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0008-6363
EI 1755-3245
J9 CARDIOVASC RES
JI Cardiovasc. Res.
PD JUN 22
PY 2022
VL 118
IS 7
BP 1742
EP 1757
DI 10.1093/cvr/cvab207
EA JUL 2021
PG 16
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 2H5LI
UT WOS:000755903300001
PM 34142125
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Couch, SC
   Saelens, BE
   Khoury, PR
   Dart, KB
   Hinn, K
   Mitsnefes, MM
   Daniels, SR
   Urbina, EM
AF Couch, Sarah C.
   Saelens, Brian E.
   Khoury, Philip R.
   Dart, Katherine B.
   Hinn, Kelli
   Mitsnefes, Mark M.
   Daniels, Stephen R.
   Urbina, Elaine M.
TI Dietary Approaches to Stop Hypertension Dietary Intervention Improves
   Blood Pressure and Vascular Health in Youth With Elevated Blood Pressure
SO HYPERTENSION
LA English
DT Article
DE adolescents; blood pressure; counseling; diet; hypertension
ID CHILDHOOD METABOLIC SYNDROME; DASH DIET; ENDOTHELIAL DYSFUNCTION;
   PHYSICAL-ACTIVITY; OXIDATIVE STRESS; CHILDREN; INFLAMMATION;
   ADOLESCENTS; ARTERY; RISK
AB This randomized control trial assessed the post-intervention and 18-month follow-up effects of a 6-month dietary approaches to stop hypertension (DASH)-focused behavioral nutrition intervention, initiated in clinic with subsequent telephone and mail contact, on blood pressure (BP) and endothelial function in adolescents with elevated BP. Adolescents (n=159) 11 to 18 years of age with newly diagnosed elevated BP or stage 1 hypertension treated at a hospital-based clinic were randomized. DASH participants received a take-home manual plus 2 face-to-face counseling sessions at baseline and 3 months with a dietitian regarding the DASH diet, 6 monthly mailings, and 8 weekly and then 7 biweekly telephone calls focused on behavioral strategies to promote DASH adherence. Routine care participants received nutrition counseling with a dietitian consistent with pediatric guidelines established by the National High Blood Pressure Education Program. Outcomes, measured pre- and post-intervention and at 18-months follow-up, included change in BP, change in brachial artery flow-mediated dilation, and change in DASH score based on 3-day diet recalls. Adolescents in DASH versus routine care had a greater improvement in systolic BP (-2.7 mm Hg, P= 0.03, -0.3 z-score, P=0.03), flow-mediated dilation (2.5%, P=0.05), and DASH score (13.3 points, P<0.0001) from baseline to post-treatment and a greater improvement in flow-mediated dilation (3.1%, P=0.03) and DASH score (7.4 points, P=0.01) to 18 months. The DASH intervention proved more effective than routine care in initial systolic BP improvement and longer term improvement in endothelial function and diet quality in adolescents with elevated BP and hypertension.
C1 [Couch, Sarah C.] Univ Cincinnati, Dept Rehabil Exercise & Nutr Sci, 3202 Eden Ave, Cincinnati, OH 45267 USA.
   [Saelens, Brian E.] Univ Washington, Dept Pediat, Seattle Childrens Res Inst, Seattle, WA 98195 USA.
   [Khoury, Philip R.; Mitsnefes, Mark M.; Urbina, Elaine M.] Cincinnati Childrens Hosp Med Ctr, Dept Pediat, Cincinnati, OH 45229 USA.
   [Dart, Katherine B.] Northside Hosp, Dept Nutr, Atlanta, GA USA.
   [Hinn, Kelli] VA Med Ctr, Dept Nutr, Richmond, VA USA.
   [Daniels, Stephen R.] Univ Colorado, Sch Med, Dept Pediat, Denver, CO USA.
C3 University System of Ohio; University of Cincinnati; University of
   Washington; University of Washington Seattle; Seattle Children's
   Hospital; Cincinnati Children's Hospital Medical Center; Hunter Holmes
   McGuire Veterinary Affairs Medical Center; University of Colorado
   System; University of Colorado Denver; University of Colorado Anschutz
   Medical Campus
RP Couch, SC (corresponding author), Univ Cincinnati, Dept Rehabil Exercise & Nutr Sci, 3202 Eden Ave, Cincinnati, OH 45267 USA.
EM sarah.couch@uc.edu
RI Daniels, Stephen/AEZ-9355-2022
OI Saelens, Brian/0000-0001-6998-6339; Urbina, Elaine/0000-0002-5640-6777;
   Khoury, Philip/0000-0003-2611-8835; Couch, Sarah/0000-0003-1042-0490
FU National Institutes of Health [R01HL088567-01A1]; National Heart Lung
   and Blood Institute
FX This study was supported by grant R01HL088567-01A1 from the National
   Institutes of Health and the National Heart Lung and Blood Institute.
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NR 46
TC 52
Z9 58
U1 1
U2 25
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0194-911X
EI 1524-4563
J9 HYPERTENSION
JI Hypertension
PD JAN
PY 2021
VL 77
IS 1
BP 241
EP 251
DI 10.1161/HYPERTENSIONAHA.120.16156
PG 11
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA PD0UQ
UT WOS:000597410500025
PM 33190559
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Zhang, M
   Hu, ML
   Huang, JJ
   Xia, SS
   Yang, Y
   Dong, K
AF Zhang, Min
   Hu, Man-Li
   Huang, Jiao-Jiao
   Xia, San-Shan
   Yang, Yan
   Dong, Kun
TI Association of leukocyte telomere length with non-alcoholic fatty liver
   disease in patients with type 2 diabetes
SO CHINESE MEDICAL JOURNAL
LA English
DT Article
DE Non-alcoholic fatty liver disease; Telomere; Type 2 diabetes mellitus
ID INSULIN-RESISTANCE; UNITED-STATES; DIAGNOSTIC-ACCURACY; METABOLIC
   SYNDROME; OXIDATIVE STRESS; NATIONAL-HEALTH; PREVALENCE; MARKERS;
   POPULATION; ULTRASOUND
AB Background: Leukocyte telomere has been shown to be related to insulin resistance-related diseases, such as type 2 diabetes mellitus (T2DM) and non-alcoholic fatty liver disease (NAFLD). This cross-sectional study investigated the association of leukocyte telomere length (LTL) with NAFLD in T2DM patients. Methods: Clinical features were collected and LTL was measured by Southern blot-based terminal restriction fragment length analysis in 120 T2DM patients without NAFLD and 120 age-matched T2DM patients with NAFLD. NAFLD was clinically defined by manifestations of ultrasonography. The correlation between LTL and clinical and biochemical parameters were analyzed by Pearson correlation or Spearman correlation analysis. Factors for NAFLD in T2DM patients were identified using multiple logistic regressions. Results: LTL in T2DM patients with NAFLD were significantly longer than those without NAFLD (6400.2 +/- 71.8 base pairs [bp] vs. 6023.7 +/- 49.5 bp, P < 0.001), especially when diabetes duration was less than 2 years. Meanwhile, the trend of shorter LTL was associated with the increased diabetes duration in T2DM patient with NAFLD, but not in T2DM patients without NAFLD. Finally, LTL (odds ratio [OR]: 1.001, 95% confidence interval [CI]: 1.000-1.002, P = 0.001), as well as body mass index (OR: 1.314, 95% CI: 1.169-1.477, P < 0.001) and triglycerides (OR: 1.984, 95% CI: 1.432-2.747, P < 0.001), had a significant association with NAFLD status in T2DM patients. Conclusions: T2DM patients with NAFLD had a significantly longer LTL than those without NAFLD. The longer LTL was especially evident in the early stage of T2DM, indicating that longer LTL may be used as a biomarker for NAFLD in T2DM patients.
C1 [Zhang, Min] Hubei Med Evaluat & Continuing Educ Off, Wuhan 430000, Hubei, Peoples R China.
   [Zhang, Min; Hu, Man-Li; Huang, Jiao-Jiao; Xia, San-Shan; Yang, Yan; Dong, Kun] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Endocrinol, 1095 Jiefang Ave, Wuhan 430000, Hubei, Peoples R China.
   [Hu, Man-Li] Huazhong Univ Sci & Technol, Wuhan Hosp 4, Tongji Med Coll, Dept Endocrinol, Wuhan 430000, Hubei, Peoples R China.
C3 Huazhong University of Science & Technology; Huazhong University of
   Science & Technology
RP Dong, K (corresponding author), Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Endocrinol, 1095 Jiefang Ave, Wuhan 430000, Hubei, Peoples R China.
EM kundong2019@hotmail.com
RI Hu, man/HPG-9675-2023; Zhang, Min/AAE-5153-2021
FU National Natural Science Foundation of China [81670754, 81600661]
FX This work was supported by grants from the National Natural Science
   Foundation of China (Nos. 81670754 and 81600661).
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NR 49
TC 9
Z9 9
U1 2
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0366-6999
EI 2542-5641
J9 CHINESE MED J-PEKING
JI Chin. Med. J.
PD DEC 20
PY 2019
VL 132
IS 24
BP 2927
EP 2933
DI 10.1097/CM9.0000000000000559
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA JY9HZ
UT WOS:000504718500005
PM 31809318
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Sato, S
   Norikura, T
   Mukai, Y
AF Sato, Shin
   Norikura, Toshio
   Mukai, Yuuka
TI Maternal quercetin intake during lactation attenuates renal inflammation
   and modulates autophagy flux in high-fructose-diet-fed female rat
   offspring exposed to maternal malnutrition
SO FOOD & FUNCTION
LA English
DT Article
ID OXIDATIVE STRESS; KIDNEY; GROWTH; RESTRICTION; ACTIVATION; INJURY;
   INFILTRATION; APOPTOSIS; PATHWAY; ADIPOSE
AB Maternal restriction of dietary proteins during pregnancy and lactation is known to induce renal disease in later life. High fructose intake causes metabolic syndrome, which results in an increased risk of chronic kidney disease development. We investigated whether quercetin intake during lactation affects high-fructose-diet-induced inflammation and autophagy flux in the kidneys of high-fructose-diet-fed adult female offspring exposed to maternal normal-protein (NP) or low-protein (LP) diets. Pregnant Wistar rats received diets containing 20% (NP) or 8% (LP) casein, and 0 or 0.2% quercetin containing NP diets (NP/NP or NP/NPQ) in experiment (Expt.) 1 and 0 or 0.2% quercetin containing LP diets (LP/LP or LP/LPQ) in Expt. 2 during lactation. At weaning, pups that received a diet of distilled water (Wa) or 10% fructose solution (Fr) were divided into six groups: NP/NP/Wa, NP/NP/Fr, NP/NPQ/Fr in Expt. 1, and LP/LP/Wa, LP/LP/Fr, LP/LPQ/Fr in Expt. 2. At week 12, macrophage infiltration, mRNA levels of TNF-alpha and IL-6, and markers of autophagy flux in the kidneys of male offspring were examined. We found that macrophage number and, TNF-alpha and IL-6 mRNA levels increased in the kidneys of the NP/NP/Fr or LP/LP/Fr, respectively. Conversely, macrophage number and IL-6 levels in the NP/NPQ/Fr or LP/LPQ/Fr decreased. LC3B-II levels were downregulated in the NP/NP/Fr or LP/LP/Fr rats. In contrast, LC3B-II levels were upregulated, while p62 levels were downregulated in the NP/NPQ/Fr and LP/LPQ/Fr rats. In conclusion, maternal quercetin intake during lactation may cause long-term alterations in inflammation and autophagy flux in the kidneys of high-fructose-diet-fed adult female offspring.
C1 [Sato, Shin; Norikura, Toshio] Aomori Univ Hlth & Welf, Dept Nutr, Aomori 0308505, Japan.
   [Mukai, Yuuka] Kanagawa Univ Human Serv, Fac Hlth & Social Work, Sch Nutr & Dietet, Yokohama, Kanagawa 2388522, Japan.
C3 Aomori University of Health & Welfare
RP Sato, S (corresponding author), Aomori Univ Hlth & Welf, Dept Nutr, Aomori 0308505, Japan.
EM s_sato3@auhw.ac.jp
FU JSPS KAKENHI Grant [17K00922]; Grants-in-Aid for Scientific Research
   [17K00922] Funding Source: KAKEN
FX The authors thank Keiko Tamakuma for her technical assistance. This work
   was supported by JSPS KAKENHI Grant (No. 17K00922).
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NR 48
TC 16
Z9 16
U1 0
U2 10
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PD AUG 1
PY 2019
VL 10
IS 8
BP 5018
EP 5031
DI 10.1039/c9fo01134j
PG 14
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA IR5NV
UT WOS:000481481700047
PM 31355385
DA 2025-06-11
ER

PT J
AU Craddock, JC
   Neale, EP
   Peoples, GE
   Probst, YC
AF Craddock, Joel C.
   Neale, Elizabeth P.
   Peoples, Gregory E.
   Probst, Yasmine C.
TI Vegetarian-Based Dietary Patterns and their Relation with Inflammatory
   and Immune Biomarkers: A Systematic Review and Meta-Analysis
SO ADVANCES IN NUTRITION
LA English
DT Review
DE inflammation; immune function; vegetarian; vegan; diet; dietary
   patterns; CRP; IL-6; meta-analysis; systematic review
ID C-REACTIVE PROTEIN; CARDIOVASCULAR RISK-FACTORS; BLOOD-CELL COUNT; VEGAN
   DIET; RHEUMATOID-ARTHRITIS; METABOLIC SYNDROME; OXIDATIVE STRESS;
   ALL-CAUSE; DISEASE; MARKERS
AB Dietary patterns with substantial proportions of energy from plant sources have been associated with favorable biomarkers of low-grade inflammation. Less is known of the relation between vegetarian-based dietary patterns and markers of inflammation and immune status. This systematic review and meta-analysis aimed to determine the relation between vegetarian-based dietary patterns and inflammatory and immune markers (C-reactive protein, tumour necrosis factor alpha, fibrinogen, natural killer cells, leukocytes, lymphocytes, thrombocytes, interleukins, and immunoglobulins). PubMed, Medline, and Cochrane scientific databases were searched to identify relevant studies. Random effects meta-analyses were conducted to assess the weighted mean differences (WMDs) for each outcome variable between vegetarian and non-vegetarian groups. Thirty observational and 10 intervention studies were included in the review. Pooled effects of vegetarian-based dietary patterns were associated with significantly lower concentrations of CRP (WMD: -0.61 mg/L; 95% CI: -0.91, -0.32 mg/L; P = 0.0001), fibrinogen (WMD: -0.22 g/L; 95% CI: -0.41, -0.04 mg/L; P = 0.02), and total leukocyte (WMD: -0.62x10(3)/mu L; 95% CI -1.13x10(3),-0.10x10(3)/mu L; P = 0.02) compared with those following non-vegetarian dietary patterns in observational studies. Insufficient data were identified for a meta-analysis of intervention studies. This study provides evidence that vegetarian-based dietary patterns are associated with lowered serum C-reactive protein, fibrinogen, and total leukocyte concentrations. Future research should focus on large-scale intervention trials, contrasting differences in inflammation and immune status and function between vegetarian and non-vegetarian-based populations.
C1 [Craddock, Joel C.; Neale, Elizabeth P.; Peoples, Gregory E.; Probst, Yasmine C.] Univ Wollongong, Sch Med, Fac Sci Med & Hlth, Wollongong, NSW, Australia.
   [Craddock, Joel C.; Probst, Yasmine C.] Illawarra Hlth & Med Res Inst, Wollongong, NSW, Australia.
C3 University of Wollongong; Illawarra Health & Medical Research Institute;
   University of Wollongong
RP Craddock, JC (corresponding author), Univ Wollongong, Sch Med, Fac Sci Med & Hlth, Wollongong, NSW, Australia.; Craddock, JC (corresponding author), Illawarra Hlth & Med Res Inst, Wollongong, NSW, Australia.
EM jcc256@uowmail.edu.au
RI Craddock, Joel/IAN-7994-2023; Neale, Elizabeth/H-8514-2019; Probst,
   Yasmine/A-1342-2008
OI Probst, Yasmine/0000-0002-1971-173X; Peoples,
   Gregory/0000-0002-8279-1787; Craddock, Joel/0000-0002-5290-3952; Neale,
   Elizabeth/0000-0002-6373-8622
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NR 108
TC 115
Z9 119
U1 1
U2 47
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 2161-8313
EI 2156-5376
J9 ADV NUTR
JI Adv. Nutr.
PD MAY
PY 2019
VL 10
IS 3
BP 433
EP 451
DI 10.1093/advances/nmy103
PG 19
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA IA4DS
UT WOS:000469514700007
PM 30947338
OA Green Published, Bronze, Green Submitted
DA 2025-06-11
ER

PT J
AU Ramos-Lopez, O
   Samblas, M
   Milagro, FI
   Zulet, MA
   Mansego, ML
   Riezu-Boj, JI
   Martinez, JA
AF Ramos-Lopez, Omar
   Samblas, Mirian
   Milagro, Fermin I.
   Zulet, M. Angeles
   Mansego, Maria L.
   Riezu-Boj, Jose I.
   Alfredo Martinez, J.
TI Association of low dietary folate intake with lower CAMKK2 gene
   methylation, adiposity, and insulin resistance in obese subjects
SO NUTRITION RESEARCH
LA English
DT Article
DE Folate; CAMKK2; Obesity; Adiposity; Insulin resistance
ID DNA METHYLATION; METABOLIC SYNDROME; WEIGHT-LOSS;
   CARDIOVASCULAR-DISEASE; ENDOTHELIAL FUNCTION; SERUM HOMOCYSTEINE;
   GLUCOSE-TOLERANCE; BARIATRIC SURGERY; OXIDATIVE STRESS; PROTEIN
AB Folate deficiency has been putatively implicated in the onset of diverse metabolic abnormalities, including insulin resistance, by altering epigenetic processes on key regulatory genes. The calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2) is involved in the regulation of critical metabolic processes such as adiposity and glucose homeostasis. This study hypothesized associations between low folate intakes and lower methylation levels of the CAMKK2 gene, with the presence of metabolic alterations in subjects with obesity. A cross-sectional ancillary study was conducted in obese subjects (n = 47) from the RESMENA study (Spain). Fat mass was measured by dual-energy x-ray absorptiometry. Dietary intake and metabolic profile were assessed by validated methods. DNA methylation and gene expression in peripheral white blood cells were analyzed by microarray approaches. A total of 51 cytosine-phosphate-guanine sites were associated with folate intake (false discovery rate values < 0.0001), including one located in the 5' untranslated region of the CAMKK2 gene (Illumina ID, cg16942632), which was selected and separately analyzed. Subjects with total folate intake lower than 300 mu g/d showed more fat mass (especially trunk fat), as well as statistically higher levels of glucose, insulin, homeostatic model assessment insulin resistance (HOMA-IR) index, cortisol, and plasminogen activator inhibitor-1 than those consuming at least or more than 300 mu g/d. Of note, folate deficiency was related to lower CAMKK2 methylation. Interestingly, CAMKK2 methylation negatively correlated with the HOMA-IR index. Furthermore, CAMKK2 expression directly correlated with HOMA-IR values. In summary, this study suggests associations between low folate intakes, lower CAMKK2 gene methylation, and insulin resistance in obese individuals. (C) 2017 Elsevier Inc. All rights reserved.
C1 [Ramos-Lopez, Omar; Samblas, Mirian; Milagro, Fermin I.; Zulet, M. Angeles; Mansego, Maria L.; Riezu-Boj, Jose I.; Alfredo Martinez, J.] Univ Navarra, Dept Nutr Food Sci & Physiol, Irunlarrea 1, Pamplona 31008, Spain.
   [Ramos-Lopez, Omar; Samblas, Mirian; Milagro, Fermin I.; Zulet, M. Angeles; Mansego, Maria L.; Riezu-Boj, Jose I.; Alfredo Martinez, J.] Univ Navarra, Ctr Nutr Res, Irunlarrea 1, Pamplona 31008, Spain.
   [Milagro, Fermin I.; Zulet, M. Angeles; Alfredo Martinez, J.] ISCIII, Biomed Res Ctr Network Physiopathol Obes & Nutr C, Madrid, Spain.
   [Zulet, M. Angeles; Riezu-Boj, Jose I.; Alfredo Martinez, J.] Navarra Inst Hlth Res IdiSNA, Pamplona, Spain.
   [Alfredo Martinez, J.] Madrid Inst Adv Studies IMDEA Food, Madrid, Spain.
C3 University of Navarra; University of Navarra; Instituto de Salud Carlos
   III; University of Navarra; IMDEA Food Institute
RP Martínez, JA (corresponding author), Univ Navarra, Dept Nutr Food Sci & Physiol, Irunlarrea 1, Pamplona 31008, Spain.; Martínez, JA (corresponding author), Univ Navarra, Ctr Nutr Res, Irunlarrea 1, Pamplona 31008, Spain.
EM jalfmtz@unav.es
RI Martínez, J./K-8709-2014; LÓPEZ, OSCAR/ABH-6978-2020; Zulet,
   M./H-1317-2017; Milagro, Fermin/F-2315-2015; Riezu-Boj,
   Jose-Ignacio/M-3748-2014; MANSEGO, MARIA/A-5687-2011
OI Riezu-Boj, Jose-Ignacio/0000-0002-1885-8457; Milagro, Fermin
   I./0000-0002-3228-9916; Ramos Lopez, Omar/0000-0002-2505-1555;
   Samblas-Garcia, Mirian/0000-0003-0866-2300; MANSEGO,
   MARIA/0000-0001-8914-7890
FU Health Department of the Government of Navarra [48/2009]; MINECO
   [AGL2013-45554-R]; CIBERobn; RETICS; Spanish Ministry of Education,
   Culture, and Sport; National Council of Science and Technology from
   Mexico (CONACYT) [CVU. 414175]; Doctoral Program in Sciences in
   Molecular Biology in Medicine (CONACyT) [PNPC 000091]; University of
   Navarra [LE/97]
FX We thank Blanca E Martinez de Morentin (physician), Salome Perez
   (nurse), Rocio de la Iglesia, Patricia Lopez-Legarrea, and Aurora
   Perez-Cornago (dietitians); Ana Lorente and Veronica Ciaurriz
   (technicians) for the excellent technical assistance; and Paul William
   Miller for English editing. This research was supported by grants from
   the Health Department of the Government of Navarra (48/2009), MINECO
   (AGL2013-45554-R), CIBERobn, and RETICS. The Spanish Ministry of
   Education, Culture, and Sport provided an FPI grant to MS, and ORL was
   supported by a postdoctoral grant from The National Council of Science
   and Technology from Mexico (CONACYT, no. CVU. 414175) in collaboration
   with the Doctoral Program in Sciences in Molecular Biology in Medicine
   (CONACyT, PNPC 000091) and the University of Navarra (LE/97). The
   authors declare not conflict of interest concerning this research.
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NR 70
TC 25
Z9 26
U1 0
U2 6
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0271-5317
J9 NUTR RES
JI Nutr. Res.
PD FEB
PY 2018
VL 50
BP 53
EP 62
DI 10.1016/j.nutres.2017.11.007
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA GB3FZ
UT WOS:000428942800006
PM 29540272
DA 2025-06-11
ER

PT J
AU Scuteri, A
   Morrell, CH
   Orru, M
   AlGhatrif, M
   Saba, PS
   Terracciano, A
   Ferreli, LAP
   Loi, F
   Marongiu, M
   Pilia, MG
   Delitala, A
   Tarasov, KV
   Schlessinger, D
   Ganau, A
   Cucca, F
   Lakatta, EG
AF Scuteri, Angelo
   Morrell, Christopher H.
   Orru, Marco
   AlGhatrif, Majid
   Saba, Pier Sergio
   Terracciano, Antonio
   Ferreli, Liana Anna Pina
   Loi, Francesco
   Marongiu, Michele
   Pilia, Maria Grazia
   Delitala, Alessandro
   Tarasov, Kirill V.
   Schlessinger, David
   Ganau, Antonello
   Cucca, Francesco
   Lakatta, Edward G.
TI Gender specific profiles of white coat and masked hypertension impacts
   on arterial structure and function in the SardiNIA study
SO INTERNATIONAL JOURNAL OF CARDIOLOGY
LA English
DT Article
DE Arterial stiffness; Pulse wave velocity; Carotid thickness; Arterial
   aging; Masked hypertension; White coat hypertension; 24 hour blood
   pressure monitoring
ID PULSE-WAVE VELOCITY; BLOOD-PRESSURE; COGNITIVE IMPAIRMENT; METABOLIC
   SYNDROME; ORGAN DAMAGE; STIFFNESS; STROKE; RISK; TERM
AB Background: There is no definite consensus on the CV burden associated to Masked hypertension (MH) or White Coat Hypertension (WCH) - conditions that can be detected by out-of-office blood pressure measurements (24 hour Ambulatory Blood Pressure Monitoring, 24 h ABPM).
   Methods: We investigated the association of WCH and MH with arterial aging, indexed by a range of parameters of large artery structure and function in 2962 subjects, taking no antihypertensive medications, who are participating in a large community-based population of both men and women over a broad age range (14-102 years).
   Results: The overall prevalence of WCH was 9.5% and was 5.0% for MH, with 54.9% of subjects classified as true normotensive and 30.6% as true hypertensive. Both WCH and MH were associated with a stiffer aorta, a less distensible and thicker common carotid artery, and greater central BP than true normotensive subjects. Notably, the profile of arterial alterations in WCH and MH did not significantly differ from what was observed in true hypertensive subjects. The arterial changes accompanying WCH and MH differed in men and women, with women showing a greater tendency towards concentric remodeling, greater parietal wall stress, and PWV than men.
   Conclusion: Both WCH, and MH are associated with early arterial aging, and therefore, neither can be regarded as innocent conditions. Future studies are required to establish whether measurement of arterial aging parameters in subjects with WCH or MH will identify subjects at higher risk of CV events and cognitive impairment, who may require more clinical attention and pharmacological intervention. (C) 2016 Published by Elsevier Ireland Ltd.
C1 [Morrell, Christopher H.; AlGhatrif, Majid; Tarasov, Kirill V.; Schlessinger, David; Lakatta, Edward G.] NIA, NIH, Baltimore, MD 21224 USA.
   [Orru, Marco; Ferreli, Liana Anna Pina; Loi, Francesco; Marongiu, Michele; Pilia, Maria Grazia; Delitala, Alessandro; Cucca, Francesco] Cittadella Univ Monserrato, Ist Ric Genet & Biomed, CNR, Cagliari, Italy.
   [Saba, Pier Sergio; Ganau, Antonello] Univ Sassari, I-07100 Sassari, Italy.
   [Terracciano, Antonio] Florida State Univ, Coll Med, Tallahassee, FL 32306 USA.
   [Morrell, Christopher H.] Loyola Univ Maryland, Baltimore, MD USA.
   [Orru, Marco] Presidio Osped A Businco, Unita Operat Complessa Cardiol, Cagliari, Italy.
C3 National Institutes of Health (NIH) - USA; NIH National Institute on
   Aging (NIA); University of Cagliari; Consiglio Nazionale delle Ricerche
   (CNR); Istituto di Ricerca Genetica e Biomedica (IRGB-CNR); University
   of Sassari; State University System of Florida; Florida State
   University; Loyola University Maryland
RP Scuteri, A (corresponding author), Policlin Tor Vergata, Hypertens Ctr, Hypertens & Nephrol Unit, Rome, Italy.
EM angeloelefante@interfree.it
RI Morrell, Christopher/AAN-3267-2021; Lakatta, Edward/AAL-1447-2020;
   Delitala, Alessandro/AAH-2697-2020; Terracciano, Antonio/H-7403-2019;
   Ganau, Antonello/D-6899-2012; Saba, Pier/AAH-3180-2019
OI Tarasov, Kirill/0000-0001-7799-4670; SCUTERI,
   ANGELO/0000-0003-4784-5441; Saba, Pier Sergio/0000-0001-8196-8491;
   CUCCA, Francesco/0000-0002-7414-1995; Lakatta,
   Edward/0000-0002-4772-0035; Marongiu, Michele/0000-0002-7289-9815;
   Terracciano, Antonio/0000-0001-5799-8885
FU NIA [NO1-AG-1-2109]; Intramural Research Program of the NIH, U.S.
   National Institute on Aging
FX The SardiNIA team was supported by Contract NO1-AG-1-2109 from the NIA.
   This research was supported in part by the Intramural Research Program
   of the NIH, U.S. National Institute on Aging.
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   Trachsel LD, 2015, J HYPERTENS, V33, P1276, DOI 10.1097/HJH.0000000000000558
   Verdecchia P, 2005, HYPERTENSION, V45, P203, DOI 10.1161/01.HYP.0000151623.49780.89
NR 31
TC 50
Z9 53
U1 0
U2 5
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0167-5273
EI 1874-1754
J9 INT J CARDIOL
JI Int. J. Cardiol.
PD AUG 15
PY 2016
VL 217
BP 92
EP 98
DI 10.1016/j.ijcard.2016.04.172
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA DO5OO
UT WOS:000377832700014
PM 27179214
OA Green Published, Green Accepted
DA 2025-06-11
ER

PT J
AU Tada, Y
   Yagi, K
   Uno, M
   Matsushita, N
   Kanematsu, Y
   Kuwayama, K
   Shimada, K
   Nishi, K
   Hirasawa, M
   Satomi, J
   Kitazato, KT
   Kageji, T
   Matsuura, E
   Nagahiro, S
AF Tada, Yoshiteru
   Yagi, Kenji
   Uno, Masaaki
   Matsushita, Nobuhisa
   Kanematsu, Yasuhisa
   Kuwayama, Kazuyuki
   Shimada, Kenji
   Nishi, Kyoko
   Hirasawa, Motohiro
   Satomi, Junichiro
   Kitazato, Keiko T.
   Kageji, Teruyoshi
   Matsuura, Eiji
   Nagahiro, Shinji
TI Improvement of Plasma Biomarkers after Switching Stroke Patients from
   Other Angiotensin II Type I Receptor Blockers to Olmesartan
SO JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
LA English
DT Article
DE Adiponectin; angiotensin-(1-7); hypertension; LDL/beta-2-glycoprotein I
   complex; olmesartan; peroxiredoxin
ID AMBULATORY BLOOD-PRESSURE; CONVERTING ENZYME 2; ALDOSTERONE SYSTEM;
   TELMISARTAN; ADIPONECTIN; HYPERTENSION; ACTIVATION; MEDOXOMIL
AB Background: Managing hypertension is crucial for preventing stroke recurrence. Some stroke patients experience resistant hypertension. In our experimental stroke model, olmesartan increased the expression of angiotensin (Ang) II converting enzyme-2. We hypothesized that switching to olmesartan affects biomarkers and the blood pressure (BP) in stroke patients whose BP is insufficiently controlled by standard doses of Ang II type I receptor blockers (ARBs) other than olmesartan. Methods: We recruited 25 patients to study our hypothesis. All had a history of stroke or silent cerebral infarction. We switched them to olmesartan (10-40 mg per day) for 12 weeks and determined their plasma level of Ang-(1-7), peroxiredoxin, oxidized low-density lipoprotein (oxLDL)/beta-2-glycoprotein I (beta 2GPI) complex, adiponectin, high mobility group box 1 (HMGB1), and tumor necrosis factor-alpha (TNF alpha) and recorded their BP before and after olmesartan treatment. Results: After switching the patients to olmesartan, their plasma level of Ang-(1-7) as a vasoprotective indicator and adiponectin regulating metabolic syndrome was increased, and peroxiredoxin and the oxLDL/beta 2GPI complex indicating its antioxidative stress and its proatherogenicity were lower than their baseline. This suggests that olmesartan may be more effective than other ARBs to improve these conditions. Neither HMGB1 nor TNF alpha reflecting an inflammatory response was affected, suggesting that the anti-inflammatory effects of olmesartan are similar to those of other ARBs. The recommended BP (<140/90) was obtained in 10 of the 25 patients after switching to olmesartan. No adverse events occurred. Conclusions: Switching from other ARBs to olmesartan may be a promising therapeutic option in patients with resistant hypertension.
C1 [Tada, Yoshiteru; Yagi, Kenji; Kanematsu, Yasuhisa; Kuwayama, Kazuyuki; Shimada, Kenji; Nishi, Kyoko; Hirasawa, Motohiro; Satomi, Junichiro; Kitazato, Keiko T.; Kageji, Teruyoshi; Nagahiro, Shinji] Univ Tokushima, Inst Hlth Biosci, Dept Neurosurg, Tokushima, Tokushima 7708503, Japan.
   [Uno, Masaaki; Matsushita, Nobuhisa] Kawasaki Med Sch, Dept Neurosurg, Kurashiki, Okayama, Japan.
   [Matsuura, Eiji] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Cell Chem, Okayama, Japan.
C3 Tokushima University; Kawasaki Medical School; Okayama University
RP Tada, Y (corresponding author), Univ Tokushima, Inst Hlth Biosci, Dept Neurosurg, 3-18-15 Kuramoto Cho, Tokushima, Tokushima 7708503, Japan.
EM yoshiteru.tada@hotmail.co.jp
OI Matsuura, Eiji/0000-0003-1681-0684
FU Grants-in-Aid for Scientific Research [26462159, 15H04950, 15K10305,
   15K10306] Funding Source: KAKEN
CR Abassi Z, 2009, BIOCHEM PHARMACOL, V78, P933, DOI 10.1016/j.bcp.2009.05.018
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NR 30
TC 6
Z9 7
U1 0
U2 2
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1052-3057
EI 1532-8511
J9 J STROKE CEREBROVASC
JI J. Stroke Cerebrovasc. Dis.
PD JUL
PY 2015
VL 24
IS 7
BP 1487
EP 1492
DI 10.1016/j.jstrokecerebrovasdis.2015.03.015
PG 6
WC Neurosciences; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Cardiovascular System & Cardiology
GA CK2OA
UT WOS:000356049000012
PM 25891757
DA 2025-06-11
ER

PT J
AU Lee, SS
   Yoo, JH
   Kang, SH
   Woo, JH
   Shin, KO
   Kim, KB
   Cho, SY
   Roh, HT
   Kim, YI
AF Lee, Sung Soo
   Yoo, Jae Ho
   Kang, Sung Hwun
   Woo, Jin Hee
   Shin, Ki Ok
   Kim, Kwi Beak
   Cho, Su Youn
   Roh, Hee Tae
   Kim, Young Il
TI The Effects of 12 Weeks Regular Aerobic Exercise on Brain-derived
   Neurotrophic Factor and Inflammatory Factors in Juvenile Obesity and
   Type 2 Diabetes Mellitus
SO JOURNAL OF PHYSICAL THERAPY SCIENCE
LA English
DT Article
DE Obesity; T2DM; BDNF
ID C-REACTIVE PROTEIN; WHITE ADIPOSE-TISSUE; NERVE GROWTH-FACTOR; INDUCED
   WEIGHT-LOSS; METABOLIC SYNDROME; MULTIPLE-SCLEROSIS; CONTROLLED-TRIAL;
   SKELETAL-MUSCLE; OLDER-ADULTS; BDNF LEVELS
AB [Purpose] The purpose of this study was to investigate the effects of 12 weeks regular aerobic exercise on brain-derived neurotrophic factor (BDNF) and inflammatory factors in juvenile obesity and type 2 diabetes mellitus (T2DM). Obesity and T2DM, typically common among adults, have recently become more prevalent in the Korean juvenile population, affecting not only their lipid profiles and oxidant stress levels, but also their BDNF and inflammatory factor levels. [Subjects] This study enrolled 26 juveniles (boys = 15, girls = 9) who were assigned to a control group (CG, n = 11), obesity group (OG, n = 8), or T2DM group (TG, n = 7). [Methods] The outcome of a 40-60-minute aerobic exercise session that took place three times per week for 12 weeks at a maximum oxygen intake (VO2max) of 50 similar to 60% was investigated. [Results] The exercise resulted in a significant reduction in the resting serum BDNF and TrkB levels (baseline) among juveniles in the OG and TG as compared to those in the CG. Additionally, the 12 weeks of regular aerobic exercise led to significant reductions in body weight, body fat percentage, and body mass index in the OG and a significant increase of VO2max in the OG and TG. However, no significant differences in serum NGF or inflammatory factors were found among the three groups. There was a significant increase in resting serum BDNF levels following the 12 weeks regular exercise only in the OG. [Conclusion] While 12 weeks of regular aerobic exercise had a positive effect on body composition, and increased BDNF levels of juveniles in the OG, it did not affect the inflammatory factor levels and had no effect on the TG.
C1 [Lee, Sung Soo; Woo, Jin Hee; Shin, Ki Ok] Dong A Univ, Coll Sports Sci, Dept Phys Educ, Pusan, South Korea.
   [Yoo, Jae Ho] Dong A Univ, Med Ctr, Dept Pediat, Coll Med, Pusan, South Korea.
   [Kim, Kwi Beak; Kim, Young Il] Young San Univ, Dept Sport & Hlth Management, Coll Sports Sci, Yangsan 626790, Gyeongnam, South Korea.
   [Cho, Su Youn; Roh, Hee Tae] Yon Sei Univ, Dept Phys Educ, Seoul, South Korea.
   [Kang, Sung Hwun] Republ Korea Airforce Acad, Dept Aero Phys Educ, Chungcheongbuk, South Korea.
C3 Dong A University; Dong A University; Yonsei University
RP Kim, YI (corresponding author), Young San Univ, Dept Sport & Hlth Management, Coll Sports Sci, 288 Junam Ro, Yangsan 626790, Gyeongnam, South Korea.
EM kyi0234@ysu.ac.kr
RI Kim, Song-Yi/JAC-5358-2023
OI Yoo, Jaeho/0000-0003-3065-944X
FU National Research Foundation of Korea Grant - Korean Government
   [NRF-2011-332-1-G00080]
FX This work was supported by the National Research Foundation of Korea
   Grant funded by the Korean Government (NRF-2011-332-1-G00080).
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NR 45
TC 46
Z9 49
U1 1
U2 12
PU SOC PHYSICAL THERAPY SCIENCE
PI TOKYO
PA C/O PUBLICATION CENTER, 1-24-12 SUGAMO, TOSHIMA-KU, TOKYO, 170-0002,
   JAPAN
SN 0915-5287
EI 2187-5626
J9 J PHYS THER SCI
JI J. Phys. Ther. Sci.
PD AUG
PY 2014
VL 26
IS 8
BP 1199
EP 1204
DI 10.1589/jpts.26.1199
PG 6
WC Rehabilitation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Rehabilitation
GA AY3FB
UT WOS:000347468800013
PM 25202180
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Simonen, M
   Männistö, V
   Leppänen, J
   Kaminska, D
   Kärjä, V
   Venesmaa, S
   Käkelä, P
   Kuusisto, J
   Gylling, H
   Laakso, M
   Pihlajamäki, J
AF Simonen, Marko
   Mannisto, Ville
   Leppanen, Joel
   Kaminska, Dorota
   Karja, Vesa
   Venesmaa, Sari
   Kakela, Pirjo
   Kuusisto, Johanna
   Gylling, Helena
   Laakso, Markku
   Pihlajamaki, Jussi
TI Desmosterol in Human Nonalcoholic Steatohepatitis
SO HEPATOLOGY
LA English
DT Article
ID FATTY LIVER-DISEASE; NON-CHOLESTEROL STEROLS; INSULIN-RESISTANCE;
   OXIDATIVE STRESS; SURROGATE MARKERS; HEPATIC STEATOSIS; FOLLOW-UP;
   METABOLISM; ABSORPTION; OBESE
AB Dysregulation of the cholesterol synthesis pathway and accumulation of cholesterol in the liver are linked to the pathogenesis of nonalcoholic steatohepatitis (NASH). Therefore, we investigated the association of serum and liver levels of cholesterol precursors with NASH. Liver histology was assessed in 110 obese patients (Kuopio Obesity Surgery Study [KOBS] study, age 43.7 +/- 8.1 years [mean +/- standard deviation, SD], body mass index [BMI] 45.0 +/- 6.1 kg/m(2)). Serum and liver levels of cholesterol precursors were measured with gas-liquid chromatography. The association between cholesterol precursors and serum alanine aminotransferase (ALT), as a marker of liver disease, was also investigated in a population cohort of 717 men (Metabolic Syndrome in Men Study [METSIM] study, age 57.6 +/- 5.8 years, BMI 27.1 +/- 4.0 kg/m(2)). Serum desmosterol levels and the desmosterol-to-cholesterol ratio were higher in individuals with NASH, but not in individuals with simple steatosis, compared to obese subjects with normal liver histology (P = 0.002 and P = 0.003, respectively). Levels of serum and liver desmosterol correlated strongly (r = 0.667, P = 1 x 10(-9)), suggesting a shared regulation. Both serum and liver desmosterol levels correlated positively with steatosis and inflammation in the liver (P < 0.05). Serum desmosterol had a higher correlation with the accumulation of cholesterol in the liver than serum cholesterol. Serum desmosterol levels (P = 2 x 10(-6)) and the serum desmosterol-to-cholesterol ratio (P = 5 x 10(-5)) were associated with serum ALT in the population study. Conclusion: Levels of desmosterol in serum and the liver were associated with NASH. These results suggest that serum desmosterol is a marker of disturbed cholesterol metabolism in the liver. Whether desmosterol has a more specific role in the pathophysiology of NASH compared to other cholesterol precursors needs to be investigated. (Hepatology 2013;53:976-982)
C1 [Simonen, Marko; Mannisto, Ville; Kuusisto, Johanna; Laakso, Markku; Pihlajamaki, Jussi] Univ Eastern Finland, Dept Med, Kuopio 70210, Finland.
   [Simonen, Marko; Mannisto, Ville; Karja, Vesa; Venesmaa, Sari; Kakela, Pirjo; Kuusisto, Johanna; Laakso, Markku; Pihlajamaki, Jussi] Kuopio Univ Hosp, SF-70210 Kuopio, Finland.
   [Simonen, Marko; Pihlajamaki, Jussi] Kuopio Univ Hosp, Clin Nutr & Obes Ctr, SF-70210 Kuopio, Finland.
   [Leppanen, Joel; Kaminska, Dorota; Gylling, Helena; Pihlajamaki, Jussi] Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio 70210, Finland.
   [Karja, Vesa] Univ Eastern Finland, Dept Pathol, Kuopio 70210, Finland.
   [Venesmaa, Sari; Kakela, Pirjo] Univ Eastern Finland, Dept Surg, Kuopio 70210, Finland.
   [Gylling, Helena] Univ Helsinki, Dept Med, Div Internal Med, Helsinki, Finland.
C3 University of Eastern Finland; University of Eastern Finland; University
   of Eastern Finland Hospital; Kuopio University Hospital; University of
   Eastern Finland; University of Eastern Finland Hospital; Kuopio
   University Hospital; University of Eastern Finland; University of
   Eastern Finland; University of Eastern Finland; University of Helsinki
RP Pihlajamäki, J (corresponding author), Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio 70210, Finland.
EM jussi.pihlajamaki@uef.fi
RI Kuusisto, Johanna/AGM-7927-2022; Kaminska, Dorota/P-7874-2017
OI Pihlajamaki, Jussi/0000-0002-6241-6859; Kaminska,
   Dorota/0000-0003-1829-576X
FU Academy of Finland [120979, 138006, 124243]; Finnish Diabetes Research
   Foundation; Finnish Cultural Foundation; Finnish Heart Foundation; TEKES
   [1510/31/06]; Commission of the European Community [LSHM-CT-2004-512013
   EUGENE2]
FX Supported by a grant from the Academy of Finland (to J.P., Contract no.
   120979; 138006; to M. L., Contract no. 124243), the Finnish Diabetes
   Research Foundation (to J.P. and M. L.), the Finnish Cultural Foundation
   (to J.P.), the Finnish Heart Foundation (to M. L.), TEKES (to M. L.,
   Contract no. 1510/31/06), and Commission of the European Community (to
   M. L., Contract no. LSHM-CT-2004-512013 EUGENE2).
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NR 45
TC 42
Z9 45
U1 0
U2 8
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0270-9139
EI 1527-3350
J9 HEPATOLOGY
JI Hepatology
PD SEP
PY 2013
VL 58
IS 3
BP 976
EP 982
DI 10.1002/hep.26342
PG 7
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 283YX
UT WOS:000329284000019
PM 23447451
OA Bronze
DA 2025-06-11
ER

PT J
AU Salonen, MK
   Kajantie, E
   Osmond, C
   Forsén, T
   Ylihärsilä, H
   Paile-Hyvärinen, M
   Barker, DJP
   Eriksson, JG
AF Salonen, Minna K.
   Kajantie, Eero
   Osmond, Clive
   Forsen, Tom
   Yliharsila, Hilkka
   Paile-Hyvarinen, Maria
   Barker, D. J. P.
   Eriksson, Johan G.
TI Developmental Origins of Physical Fitness: The Helsinki Birth Cohort
   Study
SO PLOS ONE
LA English
DT Article
ID CORONARY-HEART-DISEASE; ALL-CAUSE MORTALITY; ADULT BODY-COMPOSITION;
   MAXIMAL AEROBIC POWER; 2-KM WALK TEST; CARDIORESPIRATORY FITNESS; LATER
   LIFE; METABOLIC SYNDROME; CARDIOVASCULAR FITNESS; EARLY-CHILDHOOD
AB Background: Cardiorespiratory fitness (CRF) is a major factor influencing health and disease outcomes including all-cause mortality and cardiovascular disease. Importantly CRF is also modifiable and could therefore have a major public health impact. Early life exposures play a major role in chronic disease development. Our aim was to explore the potential prenatal and childhood origins of CRF in later life.
   Methods/Principal Findings: This sub-study of the HBCS (Helsinki Birth Cohort Study) includes 606 men and women who underwent a thorough clinical examination and participated in the UKK 2-km walk test, which has been validated against a maximal exercise stress test as a measure of CRF in population studies. Data on body size at birth and growth during infancy and childhood were obtained from hospital, child welfare and school health records. Body size at birth was not associated with adult CRF. A 1 cm increase in height at 2 and 7 years was associated with 0.21 ml/kg/min (95% CI 0.02 to 0.40) and 0.16 ml/kg/min (95% CI 0.03 to 0.28) higher VO2max, respectively. Adjustment for adult lean body mass strengthened these findings. Weight at 2 and 7 years and height at 11 years became positively associated with CRF after adult lean body mass adjustment. However, a 1 kg/m(2) higher BMI at 11 years was associated with -0.57 ml/kg/min (95% CI -0.91 to -0.24) lower adult VO2max, and remained so after adjustment for adult lean body mass.
   Conclusion/Significance: We did not observe any significant associations between body size at birth and CRF in later life. However, childhood growth was associated with CRF in adulthood. These findings suggest, importantly from a public point of view, that early growth may play a role in predicting adult CRF.
C1 [Salonen, Minna K.; Kajantie, Eero; Forsen, Tom; Yliharsila, Hilkka; Paile-Hyvarinen, Maria; Eriksson, Johan G.] Natl Inst Hlth & Welf, Dept Chron Dis Prevent, Helsinki, Finland.
   [Salonen, Minna K.] Univ Helsinki, Dept Publ Hlth, FIN-00014 Helsinki, Finland.
   [Osmond, Clive] Epidemiol Resource Ctr, Southampton, Hants, England.
   [Forsen, Tom] Vaasa Hlth Care Ctr, Diabet Unit, Vaasa, Finland.
   [Forsen, Tom] Univ Southampton, Dev Origins Hlth & Dis Div, Southampton, Hants, England.
   [Barker, D. J. P.; Eriksson, Johan G.] Univ Helsinki, Dept Gen Practice & Primary Hlth Care, Helsinki, Finland.
   [Eriksson, Johan G.] Univ Helsinki, Cent Hosp, Unit Gen Practice, FIN-00014 Helsinki, Finland.
   [Eriksson, Johan G.] Vaasa Cent Hosp, Vaasa, Finland.
   [Eriksson, Johan G.] Folkhalsan Res Ctr, Helsinki, Finland.
C3 Finland National Institute for Health & Welfare; University of Helsinki;
   University of Southampton; University of Helsinki; University of
   Helsinki; Helsinki University Central Hospital; Vaasa Central Hospital;
   Folkhalsan Research Center
RP Salonen, MK (corresponding author), Natl Inst Hlth & Welf, Dept Chron Dis Prevent, Helsinki, Finland.
EM minna.salonen@thl.fi
RI Gibbs, J. Raphael/A-3984-2010; Barker, David/A-5671-2013
OI Osmond, Clive/0000-0002-9054-4655; Eriksson, Johan/0000-0002-2516-2060
FU British Heart Foundation; Academy of Finland; Paivikki and Sakari
   Sohlberg Foundation; Finnish Cardiovascular Research Foundation; Juho
   Vainio Foundation; Jalmari and Rauha Ahokas Foundation; Yrjo Jahnsson
   Foundation; Signe and Arne Gyllenberg Foundation; Finska
   Lakaresallskapet; Samfundet Folkhalsan
FX The present study was supported by the British Heart Foundation
   (http://www.bhf.org.uk/),The Academy of Finland
   (http://www.aka.fi/en-gb/A/),the Paivikki and Sakari Sohlberg Foundation
   (http://www.pss-saatio.fi/english.htm), Finska Lakaresallskapet
   (http://www.fls.fi/sallskapet/),the Finnish Cardiovascular Research
   Foundation (http://www.sydantutkimussaatio.fi/site/?lan = 3&page_id =
   31), the Juho Vainio Foundation
   (http://www.juhovainionsaatio.fi/pages/in-english/grants/grants-applicat
   ion.php), the Jalmari and Rauha Ahokas Foundation
   (http://www.ahokkaansaatio.org/english.htm), the Yrjo Jahnsson
   Foundation (http://www.yjs.fi/index_eng.cfm), Samfundet Folkhalsan
   (http://www.folkhalsan.fi/fi/startsida/Tietoa-Folkhalsanista/Organisaati
   omme/Samfundet-Folkhalsan/) and the Signe and Arne Gyllenberg Foundation
   (http://www.gyllenberg-foundation.fi/english/foundation). The funders
   had no role in study design, data collection and analysis, decision to
   publish, or preparation of the manuscript.
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NR 52
TC 31
Z9 36
U1 0
U2 10
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JUL 22
PY 2011
VL 6
IS 7
AR e22302
DI 10.1371/journal.pone.0022302
PG 7
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 797BJ
UT WOS:000293097300029
PM 21799817
OA Green Accepted, Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Cunha, NV
   de Abreu, SB
   Panis, C
   Grassiolli, S
   Guarnier, FA
   Cecchini, R
   Mazzuco, TL
   Pinge, P
   Martins-Pinge, MC
AF Cunha, N. V.
   de Abreu, S. B.
   Panis, C.
   Grassiolli, S.
   Guarnier, F. A.
   Cecchini, R.
   Mazzuco, T. L.
   Pinge-Filho, P.
   Martins-Pinge, M. C.
TI Cox-2 inhibition attenuates cardiovascular and inflammatory aspects in
   monosodium glutamate-induced obese rats
SO LIFE SCIENCES
LA English
DT Article
DE Prostaglandins; Oxidative stress; Heart rate; Obesity; Hypertension;
   Nitric oxide
ID ROSTRAL VENTROLATERAL MEDULLA; TRYPANOSOMA-CRUZI INFECTION; FREELY
   MOVING RATS; MSG-TREATED-RATS; ADIPOSE-TISSUE; METABOLIC SYNDROME;
   CONSCIOUS RATS; NITRIC-OXIDE; PARAVENTRICULAR NUCLEUS; HYPOTHALAMIC
   OBESITY
AB Aims: The purpose of the present work was to investigate the effect of cyclooxygenase-2 (COX-2) inhibition on the cardiovascular and inflammatory aspects promoted by monosodium glutamate (MSG)-induced obesity in rats.
   Main methods: Neonatal Wistar male rats were injected with MSG (4 mg/g body weight ID) or equimolar saline (control). Treatment with celecoxib (50 mg/kg ip) or saline (0.9% NaCl ip) began at 60 days of age. At 90 days, all rats were anesthetized for catheterization of the femoral artery, and the mean arterial pressure (MAP) and heart rate (HR) were recorded once consciousness was regained.
   Key findings: MSG obese rats were hypertensive (MAP =138 +/- 4 mm Hg) compared with controls (MAP =118 +/- 2 mm Hg). After treatment with celecoxib, the hypertension was attenuated (MAP = 126 +/- 2 mm Hg) in obese rats without changes in HR. The retroperitoneal and periepididymal fat weighed more in obese rats (Obese: Retro= 7.08 +/- 0.51, Peri = 6.36 +/- 0.81, Control: Retro = 3.60 +/- 0.46; Peri =3.24 +/- 0.42), but celecoxib did not alter these parameters. Plasma nitric oxide levels were not different between groups. However, the level of plasma prostaglandins, the immunohistochemical staining of COX-2 in cardiac tissue and plasma lipoperoxidation were higher in obese rats, and celecoxib attenuated these parameters. MSG produced liver steatosis that was also attenuated following celecoxib treatment.
   Significance: Our data demonstrate an association between increased blood pressure and products of COX-2 in obese rats, suggesting a role for prostaglandins in the hypertensive and inflammatory aspects of MSG-induced obesity. (C) 2010 Elsevier Inc. All rights reserved.
C1 [Cunha, N. V.; de Abreu, S. B.; Grassiolli, S.; Martins-Pinge, M. C.] Univ Estadual Londrina, Dept Physiol Sci, Londrina, Parana, Brazil.
   [Panis, C.; Guarnier, F. A.; Cecchini, R.; Mazzuco, T. L.; Pinge-Filho, P.] Univ Estadual Londrina, Dept Pathol Sci, Londrina, Parana, Brazil.
C3 Universidade Estadual de Londrina; Universidade Estadual de Londrina
RP Martins-Pinge, MC (corresponding author), Univ Estadual Londrina, Dept Ciencias Fisiol, Ctr Ciencias Biol, BR-86051990 Londrina, PR, Brazil.
EM martinspinge@uel.br
RI Guarnier, Flávia/E-3800-2012; Mazzuco, Tania/AAG-8922-2019; Pinge-Filho,
   Phileno/G-2844-2012; Grassiolli, Sabrina/AAP-5934-2020; Martins-Pinge,
   Marli Cardoso/C-4417-2014; PANIS, CAROLINA/O-1490-2015; Mazzuco,
   Tania/A-5881-2019; Cecchini, Rubens/D-9811-2013
OI Martins-Pinge, Marli Cardoso/0000-0002-9444-1530; PANIS,
   CAROLINA/0000-0002-0104-4369; Guarnier, Flavia/0000-0001-9302-878X;
   Mazzuco, Tania/0000-0002-1669-5623; Grassiolli,
   Sabrina/0000-0001-5647-7877; Cecchini, Rubens/0000-0001-9941-2344
FU FAEPE; Coordenacao do Pessoal de Ensino Superior
FX This study was supported by FAEPE and Coordenacao do Pessoal de Ensino
   Superior (fellowship to Cunha, N.V.).
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NR 49
TC 42
Z9 41
U1 0
U2 1
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0024-3205
EI 1879-0631
J9 LIFE SCI
JI Life Sci.
PD SEP 11
PY 2010
VL 87
IS 11-12
BP 375
EP 381
DI 10.1016/j.lfs.2010.07.014
PG 7
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA 650HH
UT WOS:000281839300006
PM 20688085
OA hybrid
DA 2025-06-11
ER

PT J
AU Babish, JG
   Pacioretty, LM
   Bland, JS
   Minich, DM
   Hu, J
   Tripp, ML
AF Babish, John G.
   Pacioretty, Linda M.
   Bland, Jeffrey S.
   Minich, Deanna M.
   Hu, Jeffrey
   Tripp, Matthew L.
TI Antidiabetic Screening of Commercial Botanical Products in 3T3-L1
   Adipocytes and db/db Mice
SO JOURNAL OF MEDICINAL FOOD
LA English
DT Article
DE 3T3-L1 adipocytes; adipogenesis; adiponectin; anti-inflammatory; db/db
   mice; diabetes; metabolic syndrome
ID HUMAN ADIPOSE-TISSUE; DIABETES-MELLITUS; OXIDATIVE STRESS;
   NATURAL-PRODUCTS; NATIONAL-HEALTH; PPAR-GAMMA; TNF-ALPHA; INSULIN;
   GLUCOSE; PREVALENCE
AB Numerous botanicals are purported to improve glucose metabolism and diabetic risk factors with varying degrees of supportive evidence. We investigated 203 commercially available botanical products representing 90 unique botanical species for effects on lipogenic activity in differentiating 3T3-L1 adipocytes. Anti-inflammatory activity of 21 of these products was further assessed in tumor necrosis factor alpha (TNF alpha)-stimulated, mature 3T3-L1 adipocytes. From these results, rho-isoalpha acids, Acacia nilotica bark, fennel, and wasabi were tested in the db/db mouse model. Fifty-nine percent of the 90 unique botanicals increased adipogenesis as did the standard troglitazone relative to the solvent controls. Botanical species with the greatest percentage of positive products were Centella asiatica, Panax quinquefolius, and Phyllanthus amarus at 100%, Vitis vinifera at 80%, Humulus lupulus at 71%, Aloe barbadensis at 66%, and Momordica charantia, Phaseolus vulgaris, and Punica granatum at 60%. All 21 subset samples inhibited TNF alpha-stimulated free fatty acid release and attenuated TNFa inhibition of adiponectin secretion. Both rho-isoalpha acids and A. nilotica reduced nonfasting glucose in the db/db mouse model, whereas A. nilotica also decreased nonfasting insulin levels. A post hoc analysis of the screening results indicated that the positive predictive value of the lipogenesis assay alone was 72%, while adding the criterion of a positive response in the anti-inflammatory assays increased this figure to 82%. Moreover, this large-scale evaluation demonstrates that antidiabetic, in vitro efficacy of botanicals is more a function of manufacturing or quality control differences than the presence of marker compounds and further underscores the need to develop functional as well as analytical bases for standardization of dietary supplements.
C1 [Babish, John G.; Pacioretty, Linda M.] Bionexus, Ithaca, NY 14850 USA.
   [Bland, Jeffrey S.; Tripp, Matthew L.] MetaProteomics, Gig Harbor, WA USA.
   [Minich, Deanna M.; Hu, Jeffrey] Metagenics, Gig Harbor, WA USA.
C3 Metagenics Inc.
RP Babish, JG (corresponding author), Bionexus, Cornell Technology Pk,30 Brown Rd, Ithaca, NY 14850 USA.
EM jgb7@cornell.edu
FU Meta-Proteomics, LLC
FX We thank Dr. Jyh-Lurn Chang for assistance in manuscript preparation.
   This research was supported by Meta-Proteomics, LLC.
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NR 49
TC 31
Z9 42
U1 1
U2 19
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1096-620X
EI 1557-7600
J9 J MED FOOD
JI J. Med. Food
PD JUN
PY 2010
VL 13
IS 3
BP 535
EP 547
DI 10.1089/jmf.2009.0110
PG 13
WC Chemistry, Medicinal; Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Food Science & Technology; Nutrition &
   Dietetics
GA 606DB
UT WOS:000278400600008
PM 20521979
DA 2025-06-11
ER

PT J
AU Martin-Gronert, MS
   Fernandez-Twinn, DS
   Poston, L
   Ozanne, SE
AF Martin-Gronert, M. S.
   Fernandez-Twinn, D. S.
   Poston, L.
   Ozanne, S. E.
TI Altered hepatic insulin signalling in male offspring of obese mice
SO JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE
LA English
DT Article
DE antioxidant enzymes; insulin resistance; maternal obesity
ID PROTEIN-KINASE-C; OXIDATIVE STRESS; RECEPTOR SUBSTRATE-1; METABOLIC
   SYNDROME; MATERNAL OBESITY; DIABETIC OB/OB; MAP KINASE; LIVER;
   RESISTANCE; MUSCLE
AB Individuals exposed in utero to maternal obesity have increased risk of developing type 2 diabetes mellitus and obesity in adulthood. The molecular mechanisms underlying this association are unknown. We have therefore used a murine model of maternal obesity, in which the offspring of obese dams develop hyperinsulinaemia by 3 months of age indicative of insulin resistance. Here, we investigate the effects of maternal diet-induced obesity on the expression/phosphorylation of key hepatic insulin signalling proteins and the expression of anti-oxidant enzymes in male offspring. At 3 months of age, offspring of obese dams had decreased levels of insulin receptor substrate (IRS) 1 (P < 0.01), whereas the ratio of phosphorylated IRS1 Ser307 to total IRS1 was significantly increased (P < 0.001), suggesting that it was less active. Protein expression of the PI3K p85 alpha subunit was decreased (P < 0.01) and there was a tendency for phosphorylation of Akt at Ser473 to be reduced (P=0.08) in the offspring of obese dams. protein kinase C zeta (P < 0.001) and glycogen synthase kinase 3 beta (P < 0.05) levels were increased in these animals in comparison with controls. Maternal obesity also resulted in increased phosphorylation of p38 mitogen-activated protein kinase at Thr180/Tyr182 (P < 0.01) and raised c-Jun N-terminal kinase 1 expression (P < 0.5) in the offspring. The expression of antioxidant enzymes was also affected by maternal obesity with CuZnSOD (P < 0.001) and glutathione reductase (P < 0.05) being increased, whereas glutathione peroxidase 1 was reduced (P < 0.05) in the offspring. We conclude that maternal obesity leads to alterations in hepatic insulin signalling protein expression and phosphorylation. These molecular changes may contribute to the development of insulin resistance.
C1 [Martin-Gronert, M. S.; Fernandez-Twinn, D. S.; Ozanne, S. E.] Univ Cambridge, Metab Res Labs, Inst Metab Sci, Addenbrookes Hosp, Cambridge CB2 OQQ, England.
   [Poston, L.] Kings Coll London, St Thomass Hosp, Div Reprod & Endocrinol, London WC2R 2LS, England.
C3 University of Cambridge; Cambridge University Hospitals NHS Foundation
   Trust; Addenbrooke's Hospital; University of London; King's College
   London; Guy's & St Thomas' NHS Foundation Trust
RP Martin-Gronert, MS (corresponding author), Univ Cambridge, Metab Res Labs, Inst Metab Sci, Addenbrookes Hosp, Hills Rd,Level 4,Box 289, Cambridge CB2 OQQ, England.
EM msm32@cam.ac.uk
RI Fernandez-Twinn, Denise/B-3881-2011
OI Fernandez-Twinn, Denise/0000-0003-2610-277X; Ozanne,
   Susan/0000-0001-8753-5144; Poston, Lucilla/0000-0003-1100-2821
FU British Heart Foundation; Biotechnology and Biological Science Research
   Council; Tommy Charity
FX The authors thank Adrian Wayman and Delia Hawkes at the Metabolic
   Research Laboratories, Institute of Metabolic Sciences, University of
   Cambridge, for their expert technical assistance. This study was
   supported in part by the British Heart Foundation (M. S. Martin-Gronert
   and S. E. Ozanne), the Biotechnology and Biological Science Research
   Council (D. S. Fernandez-Twinn) and Tommy Charity (L. Poston).
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NR 41
TC 21
Z9 24
U1 0
U2 8
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 2040-1744
EI 2040-1752
J9 J DEV ORIG HLTH DIS
JI J. Dev. Orig. Health Dis.
PD JUN
PY 2010
VL 1
IS 3
BP 184
EP 191
DI 10.1017/S2040174410000231
PG 8
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA 755DH
UT WOS:000289906400005
PM 25141786
DA 2025-06-11
ER

PT J
AU Newsholme, P
   De Bittencourt, PIH
   O'Hagan, C
   De Vito, G
   Murphy, C
   Krause, MS
AF Newsholme, Philip
   De Bittencourt, Paulo I. Homem, Jr.
   O'Hagan, Ciara
   De Vito, Giuseppe
   Murphy, Colin
   Krause, Mauricio S.
TI Exercise and possible molecular mechanisms of protection from vascular
   disease and diabetes: the central role of ROS and nitric oxide
SO CLINICAL SCIENCE
LA English
DT Article
DE diabetes; endothelial vascular cell; exercise; nitric oxide; pancreatic
   beta-cell; reactive oxygen species (ROS)
ID CHRONIC KIDNEY-DISEASE; L-ARGININE; OXIDATIVE STRESS; BETA-CELLS;
   ASYMMETRIC DIMETHYLARGININE; CARDIOVASCULAR RISK; INSULIN-RESISTANCE;
   METABOLIC SYNDROME; ANGIOTENSIN-II; GLUCOSE-UPTAKE
AB It is now widely accepted that hypertension and endothelial dysfunction are associated with an insulin-resistant state and thus with the development of T2DM (Type 2 diabetes mellitus). Insulin signalling is impaired in target cells and tissues, indicating that common molecular signals are involved. The free radical NO(center dot) regulates cell metabolism, insulin signalling and secretion, vascular tone, neurotransmission and immune system function. NO(center dot) synthesis is essential for vasodilation, the maintenance of blood pressure and glucose uptake and, thus, if levels of NO(center dot) are decreased, insulin resistance and hypertension will result. Decreased blood levels of insulin, increased AngII (angiotensin II), hyperhomocysteinaemia, increased ADMA (asymmetric omega-N(G),N(G)-dimethylarginine) and low plasma L-arginine are all conditions likely to decrease NO(center dot) production and which are associated with diabetes and cardiovascular disease. We suggest in the present article that the widely reported beneficial effects of exercise in the improvement of metabolic and cardiovascular health are mediated by enhancing the flux of muscle- and kidney-derived amino acids to pancreatic and vascular endothelial cells aiding the intracellular production of NO(center dot), therefore resulting in normalization of insulin secretion, vascular tone and insulin sensitivity. Exercise may also have an impact on AngII and ADMA signalling and the production of pro- and anti-inflammatory cytokines in muscle, so reducing the progression and development of vascular disease and diabetes. NO(center dot) synthesis will be increased during exercise in the vascular endothelial cells so promoting blood flow. We suggest that exercise may promote improvements in health due to positive metabolic and cytokine-mediated effects.
C1 [Newsholme, Philip; Krause, Mauricio S.] Univ Coll Dublin, Sch Biomol & Biomed Sci, Conway Inst Biomol & Biomed Res, Dublin 4, Ireland.
   [Newsholme, Philip; O'Hagan, Ciara; De Vito, Giuseppe; Krause, Mauricio S.] Univ Coll Dublin, UCD Inst Sport & Hlth, Dublin 4, Ireland.
   [De Bittencourt, Paulo I. Homem, Jr.] Univ Fed Rio Grande do Sul, Dept Physiol, Inst Basic Hlth Sci, Porto Alegre, RS, Brazil.
   [De Bittencourt, Paulo I. Homem, Jr.] Univ Fed Rio Grande do Sul, Sch Phys Educ, Porto Alegre, RS, Brazil.
   [O'Hagan, Ciara; De Vito, Giuseppe] Univ Coll Dublin, Sch Physiotherapy & Performance Sci, Dublin 4, Ireland.
   [Murphy, Colin; Krause, Mauricio S.] Inst Technol Tallaght, BMRG, Dept Sci, Dublin 24, Ireland.
C3 University College Dublin; University College Dublin; Universidade
   Federal do Rio Grande do Sul; Universidade Federal do Rio Grande do Sul;
   University College Dublin; Technological University Dublin
RP Newsholme, P (corresponding author), Univ Coll Dublin, Sch Biomol & Biomed Sci, Conway Inst Biomol & Biomed Res, Dublin 4, Ireland.
EM philip.newsholme@ucd.ie
RI De Vito, Giuseppe/J-4499-2012; Krause, Mauricio/AAF-1160-2019; Homem de
   Bittencourt Jr., Paulo Ivo/D-1156-2011; Newsholme, Philip/D-4939-2016
OI Homem de Bittencourt Jr., Paulo Ivo/0000-0003-1907-3341; De Vito,
   Giuseppe/0000-0002-6855-9180; Newsholme, Philip/0000-0002-0500-6984;
   Krause, Mauricio/0000-0001-9814-742X
FU Health Research Board of Ireland; Enterprise Ireland; Irish Research
   Council for Science, Engineering & Technology (IRCSET); Wellcome Trust;
   Technological Sector Research (TSR): Strand III - Core Research
   Strengths Enhancement Scheme (Ireland); Conselho Nacional de
   Desenvolvimento Cientifico e Tecnologico (CNPq); Coordenacao de
   Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
FX We thank the Health Research Board of Ireland; Enterprise Ireland; Irish
   Research Council for Science, Engineering & Technology (IRCSET); The
   Wellcome Trust; Technological Sector Research (TSR): Strand III - Core
   Research Strengths Enhancement Scheme (Ireland); Conselho Nacional de
   Desenvolvimento Cientifico e Tecnologico (CNPq); and Coordenacao de
   Aperfeicoamento de Pessoal de Nivel Superior (CAPES) for providing
   research funding to our respective laboratories.
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NR 54
TC 76
Z9 80
U1 0
U2 22
PU PORTLAND PRESS LTD
PI LONDON
PA THIRD FLOOR, EAGLE HOUSE, 16 PROCTER STREET, LONDON WC1V 6 NX, ENGLAND
SN 0143-5221
J9 CLIN SCI
JI Clin. Sci.
PD MAR
PY 2010
VL 118
IS 5-6
BP 341
EP 349
DI 10.1042/CS20090433
PG 9
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 567VY
UT WOS:000275476500003
PM 19922417
DA 2025-06-11
ER

PT J
AU Shakeri-Manesch, S
   Zeyda, M
   Huber, J
   Ludvik, B
   Prager, G
   Stulnig, TM
AF Shakeri-Manesch, S.
   Zeyda, M.
   Huber, J.
   Ludvik, B.
   Prager, G.
   Stulnig, T. M.
TI Diminished upregulation of visceral adipose heme oxygenase-1 correlates
   with waist-to-hip ratio and insulin resistance
SO INTERNATIONAL JOURNAL OF OBESITY
LA English
DT Article
DE adipose tissue; inflammation; insulin resistance; macrophages; heme
   oxygenase
ID ACTIVATED-RECEPTOR-GAMMA; NECROSIS-FACTOR-ALPHA; SCAVENGER RECEPTOR;
   TISSUE MACROPHAGES; INFLAMMATORY CYTOKINES; METABOLIC SYNDROME;
   GLUCOSE-TOLERANCE; OBESE SUBJECTS; HIGH-RISK; FAT
AB Objective: Insulin resistance in visceral obesity is substantially driven by adipose tissue inflammation, particularly by macrophages accumulating in obese adipose tissue. In contrast, adipose tissue macrophages express the hemoglobin scavenger receptor (CD163) and heme oxygenase-1 (gene: HMOX1) that together protect from oxidative stress. Our aim was to evaluate the expression of CD163 and HMOX1 in intra-abdominal visceral (omental) and subcutaneous adipose tissue as well as circulating soluble CD163 concentrations in human obesity and its association with adipose tissue inflammation, body fat distribution and insulin resistance.
   Methods: CD163, HMOX1 and CD68 mRNA expression in visceral and subcutaneous adipose tissue, serum concentration of soluble CD163 in morbidly obese patients (body mass index (BMI) > 40 kg m(-2)), who underwent laparoscopic surgery for gastric banding (n = 20), matched for age and sex to controls (BMI < 30 kg m(-2); n = 20) was analyzed.
   Results: CD163 expression was highly upregulated in human adipose tissue and soluble CD163 serum concentration was elevated in obese vs lean subjects. HMOX1 was upregulated in adipose tissue by obesity as well and expressed predominantly in macrophages. Although CD163 expression strictly correlated with macrophage abundance, HMOX1 was additionally upregulated within macrophages. This upregulation was significantly lower in visceral compared with subcutaneous adipose tissue. Strikingly, relative visceral adipose tissue expression of HMOX1 negatively correlated with waist-to-hip ratio and the homeostasis model assessment of insulin resistance (both P = 0.024).
   Conclusions: Visceral obesity is associated with defective upregulation of heme oxygenase-1 in visceral adipose tissue. A lack of this antioxidative and anti-inflammatory enzyme in visceral adipose tissue could contribute to the development of insulin resistance. International Journal of Obesity (2009) 33, 1257-1264; doi:10.1038/ijo.2009.160; published online 18 August 2009
C1 [Zeyda, M.; Huber, J.; Ludvik, B.; Stulnig, T. M.] Med Univ Vienna, Dept Med 3, Clin Div Endocrinol & Metab, A-1090 Vienna, Austria.
   [Shakeri-Manesch, S.; Prager, G.] Med Univ Vienna, Dept Surg, A-1090 Vienna, Austria.
C3 Medical University of Vienna; Medical University of Vienna
RP Stulnig, TM (corresponding author), Med Univ Vienna, Dept Med 3, Clin Div Endocrinol & Metab, Wahringer Gurtel 18-20, A-1090 Vienna, Austria.
EM thomas.stulnig@meduniwien.ac.at
RI Prager, Gerald/AAS-8674-2021
OI Zeyda, Maximilian/0000-0001-5000-1974; Stulnig,
   Thomas/0000-0003-3300-6161
FU European Community's 7th Framework Programme [FP7/2007-2013]; Austrian
   Science Fund [P18776-B11]; Austrian National Bank [12735]; Austrian
   Science Fund (FWF) [P18776] Funding Source: Austrian Science Fund (FWF)
FX The research leading to these results has received funding from the
   European Community's 7th Framework Programme ( FP7/2007-2013) under
   grant agreement no. 201608, from the Austrian Science Fund ( project no.
   P18776-B11), and the Austrian National Bank ( project no. 12735; all to
   TMS).
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NR 43
TC 57
Z9 60
U1 0
U2 2
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0307-0565
EI 1476-5497
J9 INT J OBESITY
JI Int. J. Obes.
PD NOV
PY 2009
VL 33
IS 11
BP 1257
EP 1264
DI 10.1038/ijo.2009.160
PG 8
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 519WZ
UT WOS:000271801400008
PM 19687791
DA 2025-06-11
ER

PT J
AU D'Amato, F
   Noii, B
   Brancia, C
   Cocco, C
   Flore, G
   Collu, M
   Nicolussi, P
   Ferri, GL
AF D'Amato, Filomena
   Noii, Barbara
   Brancia, Carla
   Cocco, Cristina
   Flore, Giovanna
   Collu, Maria
   Nicolussi, Paola
   Ferri, Gian-Luca
TI Differential distribution of VGF-derived peptides in the adrenal medulla
   and evidence for their selective modulation
SO JOURNAL OF ENDOCRINOLOGY
LA English
DT Article
ID NERVE GROWTH-FACTOR; METABOLIC SYNDROME; MOLECULAR-CLONING; INDUCED
   OBESITY; ENERGY-BALANCE; GENE; PROTEIN; EXPRESSION; ENDOCRINE; CELLS
AB While vgf gene knockout mice are hyperactive and hypermetabolic, surprisingly the TLQP-21 brain VGF peptide increased energy consumption, Suggesting that opposing regulatory effects could be exerted by peptides alternatively cleaved from the VGF precursor. Using antisera to the VGF precursor C-terminus and three cleavage products, we revealed a distinct differential distribution in adrenal, certain peptides (VGF(422-430): PGH peptides) being found throughout bovine and swine medulla, while C-terminus and TLQP peptides were confined to adrenaline cells in the above species and in rat and C-terminally shortened forms (VGF(604-612): HVLL peptides) to nor-adrenaline cells. Random abattoir samples of bovine and swine adrenal contained 520 +/- 40 and 450 +/- 60 pmol/g (mean +/- S.E.M. respectively) of C-terminus peptides and similar or lower amounts of others. Upon gel chromatography, bona fide VGF precursor, similar to 7.5 and similar to 3.5 kDa forms were revealed by C-terminus assays, HVLL peptides being limited to small fragments. TLQP peptides included similar to 7.5 kDa form and peaks accounting for TLQP-21 and predicted TLQP-30 and TLQP-42. Low molecular weight (MW) PGH peptides were revealed, together with a high MW form possibly encompassing the VGF precursor N-terminus. In acutely stressed swine, a striking increase was seen for C-terminus and TLQP peptides, with no significant differences for PGH peptides. A similar response was found in rat TLQP peptides showing a major increase upon an acute swimming stress and 30 min thereafter. A differential processing of the VGF precursor encompassing many areas of its primary sequence and selective modulations of its derived peptides occur in adrenal medullary cells, possibly relevant to adaptive homeostatic responses.
C1 [D'Amato, Filomena; Noii, Barbara; Brancia, Carla; Cocco, Cristina; Ferri, Gian-Luca] Univ Cagliari, Dept Cytomorphol, NEF Lab, I-09042 Cagliari, Italy.
   [Flore, Giovanna; Collu, Maria] Univ Cagliari, Dept Neurosci, I-09042 Cagliari, Italy.
   [Nicolussi, Paola] Ist Zooprofilatt Sperimentale, I-07100 Sassari, Italy.
C3 University of Cagliari; University of Cagliari; IZS Sicilia
RP Ferri, GL (corresponding author), Univ Cagliari, Dept Cytomorphol, NEF Lab, I-09042 Cagliari, Italy.
EM ferri@unica.it
RI Ferri, Luca Angelo/AAC-5890-2022; Collu, Maria/F-7113-2012
OI Flore, Giovanna/0000-0003-2560-8613; Ferri, Luca
   Angelo/0000-0001-9031-6284; FERRI, Gian-Luca/0000-0003-2768-349X; Collu,
   Maria/0000-0001-5406-2934; BRANCIA, CARLA/0000-0002-0716-3983
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NR 26
TC 21
Z9 23
U1 0
U2 7
PU SOC ENDOCRINOLOGY
PI BRISTOL
PA 22 APEX COURT, WOODLANDS, BRADLEY STOKE, BRISTOL BS32 4JT, ENGLAND
SN 0022-0795
J9 J ENDOCRINOL
JI J. Endocrinol.
PD MAY
PY 2008
VL 197
IS 2
BP 359
EP 369
DI 10.1677/JOE-07-0346
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 302PL
UT WOS:000255980600018
PM 18434366
OA Bronze
DA 2025-06-11
ER

PT J
AU Brook, RD
   Jerreft, M
   Brook, JR
   Bard, RL
   Finkelstein, MM
AF Brook, Robert D.
   Jerreft, Michael
   Brook, Jeffrey R.
   Bard, Robert L.
   Finkelstein, Murray M.
TI The relationship between diabetes mellitus and traffic-related air
   pollution
SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
LA English
DT Article
ID ACTIVATED SIGNALING PATHWAYS; OXIDATIVE STRESS; CARDIOVASCULAR-DISEASE;
   ATHEROSCLEROSIS RISK; INSULIN-RESISTANCE; METABOLIC SYNDROME; EXPOSURE;
   PREVALENCE; MORTALITY; POPULATION
AB Objective: Air pollution is associated with an increased risk for cardiovascular events. Many of the biological pathways involved could also promote diabetes mellitus (DM). We therefore investigated the association between DM prevalence and exposure to traffic-related air pollution (nitrogen dioxide [NO2]). Methods: Study participants were patients who attended two respiratory clinics in Hamilton (n = 5228) and Toronto (n = 2406). The diagnosis of DM was ascertained by linkage to administrative databases of the Ontario universal Health Insurance Plan for patients aged 40 years and above. Geographic Information systems methodology was used to assign individual estimates of NO2 based oil a network of samplers in each city. Logistic regression was used to estimate the relations between NO2 exposures and the odds of DM diagnosis. Results: After adjusting for age, body mass index, and neighborhood income there were positive effects in women on the odds ratio for DM for each 1 ppb NO2 exposure in Toronto (OR 1.055, 95% CI: 0.99 to 1.11) and Hamilton (OR 1.029, 95% CI: 0.98 to 1.08). In a meta-analytic model including both cities, there was a significant effect in women (OR = 1.04; 95% CI: 1.00 to 1.08). Across the inter-quartile range (similar to 4 ppb NO2) there was nearly a 17% increase in the odds of DM for women. There were no positive associations among men. Conclusions: Exposure to NO2, a marker of traffic-related air pollutants, was associated with DM prevalence among women. Exposure estimate errors in men may explain the apparent gender difference. These results suggest that common air pollutants are associated with DM and warrant more investigation to determine if this is a cause-and-effect relationship.
C1 [Brook, Robert D.; Bard, Robert L.] Univ Michigan, Div Cardiovasc Med, Ann Arbor, MI 48109 USA.
   [Jerreft, Michael] Univ Calif Berkeley, Sch Publ Hlth, Berkeley, CA 94720 USA.
   [Brook, Jeffrey R.] Environm Canada, Gatineau, PQ, Canada.
   [Finkelstein, Murray M.] Univ Toronto, Dept Family & Community Med, Toronto, ON M5S 1A1, Canada.
C3 University of Michigan System; University of Michigan; University of
   California System; University of California Berkeley; Environment &
   Climate Change Canada; University of Toronto
RP Brook, RD (corresponding author), 24 Frank Llyod Wright Dr POB 322, Ann Arbor, MI 48106 USA.
EM robdbrok@umich.edu
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NR 45
TC 198
Z9 227
U1 0
U2 76
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1076-2752
EI 1536-5948
J9 J OCCUP ENVIRON MED
JI J. Occup. Environ. Med.
PD JAN
PY 2008
VL 50
IS 1
BP 32
EP 38
DI 10.1097/JOM.0b013e31815dba70
PG 7
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA 250UI
UT WOS:000252326100009
PM 18188079
DA 2025-06-11
ER

PT J
AU Chiang, AA
AF Chiang, Ambrose A.
TI Obstructive sleep apnea and chronic intermittent hypoxia: A review
SO CHINESE JOURNAL OF PHYSIOLOGY
LA English
DT Review
DE chronic intermittent hypoxia; obstructive sleep apnea; sleep
   fragmentation
ID POSITIVE AIRWAY PRESSURE; C-REACTIVE PROTEIN; INSULIN-RESISTANCE;
   EPISODIC HYPOXIA; OXIDATIVE STRESS; HEART-FAILURE; NITRIC-OXIDE;
   HYPERACTIVITY; ASSOCIATION; MEN
AB Hypoxia is an important topic both physiologically and clinically. Traditionally, physiology research has been focusing on the effect of acute and chronic sustained hypoxia and human adaptive response to high altitude. In the past 20 years, genetic studies by many have expanded our understanding of hypoxia to the molecular level. However, in contrast to our extensive knowledge about acute and chronic sustained hypoxia, we know relatively little about the effect of chronic intermittent hypoxia (CIH).
   In recent years, CIH has attracted more research attention because of the increasing prevalence of obesity and obstructive sleep apnea (OSA) in the western countries. Clinically, CIH is commonly seen in patients with sleep-disordered breathing including OSA, Cheyne-Stokes respiration and nocturnal hypoventilation. It was estimated that for OSA of at least mild severity prevalence estimates range from 3 to 28% in the general population. OSA is characterized by recurrent upper airway collapse during sleep leading to intermittent nocturnal hypoxia and sleep fragmentation. OSA is associated with significant mortality and morbidity including neurocognitive dysfunction, hypertension, many cardiovascular disorders and metabolic disorders such as diabetes and metabolic syndrome.
   The intermittent hypoxia in OSA closely mimics what is seen in the ischemia-reperfusion injury. Experimentally, there is no universally accepted definition for CIH. Laboratory protocols vary greatly in duration of hypoxia exposure, numbers of hypoxia episodes per day and the total number of days of exposure. Despite the lack of a uniform definition, recent data suggest that CIH may lead to multiple long-term pathophysiologic consequences similar to what we see in patients with OSA. Recent evidences also demonstrate that there are remarkable differences in the response of the physiologic systems to sustained hypoxia and intermittent hypoxia.
   This review is aimed to briefly discuss the clinical significance of sleep-disordered breathing and our current understanding of CIH.
C1 Duke Univ, Med Ctr, Dept Med, Div Pulm & Crit Care Med, Durham, NC 27710 USA.
C3 Duke University
RP Chiang, AA (corresponding author), Duke Univ, Med Ctr, Dept Med, Div Pulm & Crit Care Med, DUMC 2733, Durham, NC 27710 USA.
EM ambrose.chiang@duke.edu
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NR 57
TC 63
Z9 69
U1 1
U2 19
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, 400059, INDIA
SN 0304-4920
EI 2666-0059
J9 CHINESE J PHYSIOL
JI Chin. J. Physiol.
PD OCT 31
PY 2006
VL 49
IS 5
BP 234
EP 243
PG 10
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA 100SX
UT WOS:000241690100003
PM 17294831
DA 2025-06-11
ER

PT J
AU Baker, JF
   Wipfler, K
   Olave, M
   Pedro, S
   Katz, P
   Michaud, K
AF Baker, Joshua F.
   Wipfler, Kristin
   Olave, Marianna
   Pedro, Sofia
   Katz, Patricia
   Michaud, Kaleb
TI Obesity, Adipokines, and Chronic and Persistent Pain in Rheumatoid
   Arthritis
SO JOURNAL OF PAIN
LA English
DT Article
DE Rheumatoid arthritis; obesity; adipokines
ID NATIONAL-DATA-BANK; METABOLIC SYNDROME; LEPTIN; OSTEOARTHRITIS;
   ASSOCIATION; SCALE
AB We aimed to determine whether adipokines are associated with pain and polysymptomatic distress in patients with rheumatoid arthritis (RA) over time in a large patient registry. The cohort study was conducted in a subset of Forward; a patient-based multi-disease, multipurpose rheumatic disease registry with patients enrolled from community-based rheumatology practices across the U.S. Adipokines (adiponectin, leptin, and fibroblast growth factor[FGF]-21) were measured on stored serum as part of a multi-analyte panel. Body mass index (BMI), pain, polysymptomatic distress, and other patient-reported outcomes (PROs) were reported on biannual questionnaires. Linear regression was used to evaluate independent associations between BMI, adipokines, and PROs. Cox proportional hazards models evaluated independent associations between adipokines and clinically meaningful changes in pain over time (change in numerical rating > 1.1 [range 0-10], sustained over 1 year). Among 645 patients included in these analyses, there were significant differences in RA characteristics, comorbidity, PROs, and adipokines across obesity categories. Of note, severely obese patients were more likely to experience greater pain, polysymptomatic distress, and fatigue. Patients with higher FGF-21 levels had higher pain and polysymptomatic stress at baseline, were more likely to use opioids, and were more likely to have sustained worsening pain over time [HR (per 1 SD) (95% CI): 1.22 (1.02,1.46) P = .03] independent of BMI. Obesity and elevated levels of FGF-21 are associated with pain and polysymptomatic distress in RA. Elevated FGF21 levels may help identify those at risk of worsening pain trajectories over time, independent of BMI. Perspective: This study characterizes the relationship between severe obesity and pain and polysymptomatic distress in patients with rheumatoid arthritis and demonstrates that the adipocytokine fibroblast growth factor-21 is independently associated with pain and predicts a worsening trajectory over time. Further mechanistic studies are needed.(R) Published by Elsevier Inc. on behalf of United States Association for the Study of Pain, Inc
C1 [Baker, Joshua F.; Olave, Marianna] Corporal Michael J Crescenz VA Med Ctr, Dept Med, Philadelphia, PA USA.
   [Baker, Joshua F.] Univ Penn, Perelman Sch Med, Philadelphia, PA USA.
   [Baker, Joshua F.] Univ Penn, Perelman Sch Med, Dept Biostat & Epidemiol, Philadelphia, PA USA.
   [Wipfler, Kristin; Pedro, Sofia; Michaud, Kaleb] Forward, Natl Databank Rheumat Dis, Wichita, KS USA.
   [Katz, Patricia] Univ Calif San Francisco, Sch Med, San Francisco, CA USA.
   [Michaud, Kaleb] VA Nebraska Western Iowa Hlth Care Syst, Dept Surg, Omaha, NE USA.
   [Michaud, Kaleb] Univ Nebraska Med Ctr, Omaha, NE USA.
   [Baker, Joshua F.] Hosp Univ Penn, Dept Med, Div Rheumatol, 5 White Bldg,3400 Spruce St, Philadelphia, PA 19104 USA.
C3 University of Pennsylvania; University of Pennsylvania; National Data
   Bank for Rheumatic Diseases; University of California System; University
   of California San Francisco; US Department of Veterans Affairs; Veterans
   Health Administration (VHA); VA Nebraska-Western Iowa Health Care
   System; University of Nebraska System; University of Nebraska Medical
   Center; University of Pennsylvania
RP Baker, JF (corresponding author), Hosp Univ Penn, Dept Med, Div Rheumatol, 5 White Bldg,3400 Spruce St, Philadelphia, PA 19104 USA.
EM bakerjo@uphs.upenn.edu
FU VA Clinical Science Research Development Merit Award [CX001703]
FX This work was supported by a VA Clinical Science Research Development
   Merit Award (CX001703) .
CR Baker JF, 2022, RHEUMATOLOGY, V61, P4924, DOI 10.1093/rheumatology/keac191
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NR 34
TC 4
Z9 4
U1 1
U2 4
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 1526-5900
EI 1528-8447
J9 J PAIN
JI J. Pain
PD OCT
PY 2023
VL 24
IS 10
BP 1813
EP 1819
DI 10.1016/j.jpain.2023.05.008
EA SEP 2023
PG 7
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA U5BG9
UT WOS:001084944100001
PM 37207978
OA Bronze
DA 2025-06-11
ER

PT J
AU Giannouli, A
   Stefanaki, C
   Kouskoutis, C
   Konidari, M
   Mani, I
   Konidari, K
   Markantonis, SL
   Mantzou, A
   Dourakis, SP
   Deligeoroglou, E
   Bacopoulou, F
AF Giannouli, Aikaterini
   Stefanaki, Charikleia
   Kouskoutis, Christos
   Konidari, Marianna
   Mani, Iliana
   Konidari, Konstantina
   Markantonis, Sophia L.
   Mantzou, Aimilia
   Dourakis, Spyridon P.
   Deligeoroglou, Efthymios
   Bacopoulou, Flora
TI Hepatokine Profile in Adolescents with Polycystic Ovary Syndrome: A
   Case-Control Study
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Article
DE polycystic ovary syndrome; PCOS; NAFLD; liver; hepatokines; fatty liver
   disease; SHBG; selenoprotein; FGF21; fetuin; adolescents; Greece
ID NONALCOHOLIC FATTY LIVER; HORMONE-BINDING GLOBULIN; GROWTH-FACTOR 21;
   FETUIN-A LEVELS; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   SELENOPROTEIN-P; GLYCOPROTEIN/FETUIN-A; HEPATIC STEATOSIS; OXIDATIVE
   STRESS
AB The current guidelines suggest routine screening for non-alcoholic fatty liver disease (NAFLD) in patients with polycystic ovary syndrome (PCOS). Hepatokines seem to be promising surrogate endpoints for the diagnosis and severity of NAFLD. PCOS has its onset in adolescence and its metabolic sequalae begin during the same period. There are scarce data on the hepatokine profile of adolescent PCOS patients. This case-control study examined the serum profile of the hepatokines sex hormone-binding globulin (SHBG), selenoprotein P, fibroblast growth factor 21 (FGF21), and fetuin A in a sample of adolescent PCOS patients, and their association to metabolic and hormonal parameters. The selenoprotein P and SHBG serum concentrations were significantly decreased in PCOS patients vs. the controls (median (IQR), 2.47 (0.40) vs. 2.66 (0.36) & mu;g/mL, p = 0.025; mean & PLUSMN; SD, 41.71 & PLUSMN; 19.41 vs. 54.94 & PLUSMN; 22.12 nmol/L, p = 0.011, respectively), whereas selenoprotein P was significantly and positively associated with testosterone (r = 0.325, p = 0.007) and the free androgen index (r = 0.361, p = 0.002). The SHBG demonstrated multiple significant negative correlations with adverse metabolic parameters. Among the PCOS patients, the FGF21 concentrations were significantly higher in those with NAFLD, whereas a 1 pg/mL increase in the FGF21 concentration increased the odds of NAFLD diagnosis by liver ultrasound by 1%, suggesting FGF21 as a potential biomarker for hepatic disease in females with PCOS in adolescence. Fetuin A was the least differentiated hepatokine between the PCOS patients and controls with the least associations with metabolic and hormonal parameters.
C1 [Giannouli, Aikaterini; Stefanaki, Charikleia; Konidari, Konstantina; Bacopoulou, Flora] Natl & Kapodistrian Univ Athens, Ctr Adolescent Med, Athens 11527, Greece.
   [Giannouli, Aikaterini; Stefanaki, Charikleia; Konidari, Konstantina; Bacopoulou, Flora] Natl & Kapodistrian Univ Athens, Aghia Sophia Childrens Hosp, UNESCO Chair Adolescent Hlth Care, Med Sch,Dept Pediat 1, Athens 11527, Greece.
   [Kouskoutis, Christos; Markantonis, Sophia L.] Natl & Kapodistrian Univ Athens, Fac Pharm, Dept Pharmaceut Technol, Lab Biopharmaceut & Pharmacokinet, Athens 15771, Greece.
   [Konidari, Marianna] Natl & Kapodistrian Univ Athens, Aretaieio Hosp, Med Sch, Dept Radiol, Athens 11528, Greece.
   [Mani, Iliana; Dourakis, Spyridon P.] Natl & Kapodistrian Univ Athens, Hippokratio Hosp, Med Sch, Dept Internal Med 2, Athens 11527, Greece.
   [Mantzou, Aimilia] Natl & Kapodistrian Univ Athens, Aghia Sophia Childrens Hosp, Sch Med, Dept Pediat 1,Div Endocrinol Metab & Diabet, Athens 11527, Greece.
   [Deligeoroglou, Efthymios] Mitera Childrens Hosp, Dept Pediat & Adolescent Gynecol, Athens 15123, Greece.
C3 National & Kapodistrian University of Athens; National & Kapodistrian
   University of Athens; The Aghia Sophia Children's Hospital; National &
   Kapodistrian University of Athens; National & Kapodistrian University of
   Athens; Hippokration General Hospital; National & Kapodistrian
   University of Athens; The Aghia Sophia Children's Hospital; National &
   Kapodistrian University of Athens; Athens Medical School
RP Bacopoulou, F (corresponding author), Natl & Kapodistrian Univ Athens, Ctr Adolescent Med, Athens 11527, Greece.; Bacopoulou, F (corresponding author), Natl & Kapodistrian Univ Athens, Aghia Sophia Childrens Hosp, UNESCO Chair Adolescent Hlth Care, Med Sch,Dept Pediat 1, Athens 11527, Greece.
EM giannouli.katerina@gmail.com; cstefanaki@gmail.com;
   ckouskoutis@pharm.uoa.gr; marianna_konidari@hotmail.com;
   ilianamani@windowslive.com; konna.kon13@gmail.com; kyroudi@pharm.uoa.gr;
   amantzou@med.uoa.gr; spdour@med.uoa.gr; deligeoroglou@yahoo.gr;
   fbacopoulou@med.uoa.gr
RI Markantonis, Sophia/HGB-3468-2022; Stefanaki, Charikleia/G-6653-2012;
   Bacopoulou, Flora/AAH-1218-2019
OI Stefanaki, Charikleia/0000-0003-1634-701X; Bacopoulou,
   Flora/0000-0003-1001-0926; Konidari, Marianna/0000-0003-2678-0845;
   MANTZOU, EMILIA/0000-0001-6606-8647
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NR 92
TC 4
Z9 4
U1 0
U2 4
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD SEP
PY 2023
VL 12
IS 17
AR 5744
DI 10.3390/jcm12175744
PG 15
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA R0EX3
UT WOS:001061167500001
PM 37685811
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Reis-Barbosa, PH
   Marcondes-de-Castro, IA
   Marinho, TD
   Aguila, MB
   Mandarim-de-Lacerda, CA
AF Reis-Barbosa, Pedro Henrique
   Marcondes-de-Castro, Ilitch Aquino
   de Souza Marinho, Thatiany
   Aguila, Marcia Barbosa
   Mandarim-de-Lacerda, Carlos Alberto
TI The mTORC1/AMPK pathway plays a role in the beneficial effects of
   semaglutide (GLP-1 receptor agonist) on the liver of obese mice
SO CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY
LA English
DT Article
DE Obesity; Type 2 diabetes; Liver; GLP-1 receptor agonist; Molecular
   analysis
ID HIGH-FAT DIET; METABOLIC SYNDROME; MOUSE MODEL; LIPOGENESIS; STRESS;
   AMPK
AB Purpose: The liver regulates lipid metabolism. Decreasing mTOR (mechanistic target of rapamycin complex 1) and enhancing AMPK (AMP-activated protein kinase) help degrade hepatic diet-induced accumulated lipids. Therefore, the glucagon-like peptide type 1 receptor agonist (GLP-1) is indicated to treat obesity-related liver metabolic alterations. Then, we investigated the effects of semaglutide (recent GLP-1) by analyzing the liver mTORC1/AMPK pathway genes in obese mice. Basic procedures: C57BL/6 male mice were separated into two groups and submitted for 16 weeks of obesity induction. Then they were treated for an additional four weeks with semaglutide (subcutaneous, 40 mg/kg once every three days). The groups formed were: C, control group; CS, control group plus semaglutide; HF, high-fat group; HFS, high-fat group plus semaglutide. Next, the livers were dissected, and rapidly fragments of all lobes were kept and frozen at -80 degrees C for analysis (RT-qPCR). Main findings: Liver markers for the mTOR pathway associated with anabolism and lipogenesis de novo were increased in the HF group compared to the C group but comparatively attenuated by semaglutide. Also, liver markers for the AMPK pathway, which regulates chemical pathways involving the cell's primary energy source, were impaired in the HF group than in the C group but partly restored by semaglutide. Conclusion: the mTOR pathway was attenuated, and the insulin signaling and the AMPK pathway were enhanced by semaglutide, ameliorating the liver gene expressions related to the metabolism of obese mice. These findings are promising in delaying the progression of nonalcoholic fatty liver disease. (c) 2022 Elsevier Masson SAS. All rights reserved.
C1 [Reis-Barbosa, Pedro Henrique; Marcondes-de-Castro, Ilitch Aquino; de Souza Marinho, Thatiany; Aguila, Marcia Barbosa; Mandarim-de-Lacerda, Carlos Alberto] Univ Estado Rio De Janeiro, Inst Biol, Biomed Ctr, Lab Morphometry Metab & Cardiovasc Dis, Rio De Janeiro, Brazil.
   [Mandarim-de-Lacerda, Carlos Alberto] Univ Estado Rio De Janeiro, Ctr Biomed, Lab Morfometria Metab & Doenca Cardiovasc, 28 Setembro 87 fds, BR-20551030 Rio De Janeiro, RJ, Brazil.
C3 Universidade do Estado do Rio de Janeiro; Universidade do Estado do Rio
   de Janeiro
RP Mandarim-de-Lacerda, CA (corresponding author), Univ Estado Rio De Janeiro, Ctr Biomed, Lab Morfometria Metab & Doenca Cardiovasc, 28 Setembro 87 fds, BR-20551030 Rio De Janeiro, RJ, Brazil.
EM mandarim@uerj.br
RI Aguila, Marcia/P-2349-2019; Reis Barbosa, Pedro Henrique/V-2653-2018;
   Mandarim-de-Lacerda, Carlos/P-2360-2019
OI Aquino Marcondes de Castro, Ilitch/0000-0003-3104-4033; Reis Barbosa,
   Pedro Henrique/0000-0002-4731-7422; Mandarim-de-Lacerda,
   Carlos/0000-0003-4134-7978; MARINHO, THATIANY/0000-0001-9976-9466;
   Barbosa Aguila, Marcia/0000-0003-3994-4589
FU Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (Brazil)
   (CNPq) [40.60.81/2018-2, 305993/2021-6]; Fundacao Carlos Chagas Filho de
   Amparoa Pesquisa do Estado do Rio de Janeiro (Faperj)
   [E-26/010.001274/2016, E-26/010.100947/2018, E-26/200.936/2021];
   Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior, CAPES,
   Brazil [001]
FX Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (Brazil)
   (CNPq, Grant No 40.60.81/2018-2 and 305993/2021-6 to CAML), Fundacao
   Carlos Chagas Filho de Amparoa Pesquisa do Estado do Rio de Janeiro
   (Faperj, Grant No E-26/010.001274/2016, E-26/010.100947/2018, and
   E-26/200.936/2021 to CAML). PRB and IMC received a bursary, Coordenacao
   de Aperfeicoamento de Pessoal de Nivel Superior, CAPES, Brazil (Finance
   Code 001). These foundations had no interference in the accomplishment
   and submission of the study.
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NR 40
TC 27
Z9 27
U1 1
U2 20
PU ELSEVIER MASSON, CORP OFF
PI PARIS
PA 65 CAMILLE DESMOULINS CS50083 ISSY-LES-MOULINEAUX, 92442 PARIS, FRANCE
SN 2210-7401
EI 2210-741X
J9 CLIN RES HEPATOL GAS
JI Clin. Res. Hepatol. Gastroenterol.
PD JUN-JUL
PY 2022
VL 46
IS 6
AR 101922
DI 10.1016/j.clinre.2022.101922
PG 9
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 2S4ZS
UT WOS:000821802700007
PM 35427802
DA 2025-06-11
ER

PT J
AU Meishuo, O
   Eshak, ES
   Muraki, I
   Cui, RZ
   Shirai, K
   Iso, H
   Tamakoshi, A
AF Meishuo, Ouyang
   Eshak, Ehab S.
   Muraki, Isao
   Cui, Renzhe
   Shirai, Kokoro
   Iso, Hiroyasu
   Tamakoshi, Akiko
TI Association between Dietary Manganese Intake and Mortality from
   Cardiovascular Disease in Japanese Population: The Japan Collaborative
   Cohort Study
SO JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
LA English
DT Article
DE Manganese; Cardiovascular disease; Mortality; Cohort studies; Japan
ID HORMONE-BINDING GLOBULIN; METABOLIC SYNDROME; SUPEROXIDE-DISMUTASE;
   OXIDATIVE STRESS; COPPER; RISK; ABSORPTION; RETENTION; PROFILE; ADULTS
AB Aim: Manganese (Mn) is an essential element in the human body, and it has a significant impact on cardiovascular risk factors such as diabetes, blood pressure, and cholesterol levels. However, no research has been conducted on the association between Mn and cardiovascular disease (CVD), to the best of our knowledge. This study thus examined the association between dietary Mn intake and CVD mortality in the general Japanese population. Methods: The CVD mortality among 58,782 participants from the Japan Collaborative Cohort Study (JACC) aged 40???79 years was determined during a median follow-up period of 16.5 years. The Mn intake was estimated using a food frequency questionnaire at the baseline (1989???1990), and multivariate-adjusted hazard ratios (HRs) for mortality were computed according to quintiles of energy-adjusted Mn intake. Results: During the follow-up period, a total of 3408 CVD deaths were recorded. Participants in the highest quintile of Mn intake had a lower risk of mortality from total stroke (HR:95% CI, 0.76: 0.64???0.90), ischemic stroke (HR: 0.77, 0.61???0.97), ischemic heart disease (HR: 0.76, 0.58???0.98), and total CVD (HR: 0.86, 0.76??? 0.96) compared with those in the lowest quintile. The reduced risk of mortality from intraparenchymal hemorrhage with high Mn intake was observed among women (HR: 0.60, 0.37???0.96) but not men (HR: 0.93, 0.59???1.47). The observed associations were more robust in postmenopausal than in premenopausal women. Conclusions: Our study is the first to show the prospective association between dietary Mn intake and reduced risk of mortality from CVD in the Japanese population.
C1 [Meishuo, Ouyang; Eshak, Ehab S.; Muraki, Isao; Cui, Renzhe; Shirai, Kokoro; Iso, Hiroyasu] Osaka Univ, Grad Sch Med, Dept Social Med, Publ Hlth, Osaka, Japan.
   [Eshak, Ehab S.] Minia Univ, Publ Hlth & Community Med Dept, Fac Med, Al Minya, Egypt.
   [Tamakoshi, Akiko] Hokkaido Univ, Dept Social Med, Publ Hlth, Fac Med, Sapporo, Hokkaido, Japan.
C3 The University of Osaka; Egyptian Knowledge Bank (EKB); Minia
   University; Hokkaido University
RP Iso, H (corresponding author), Osaka Univ, Grad Sch Med, Dept Social Med, Publ Hlth, Suita, Osaka 5650871, Japan.
EM iso@pbhel.med.osaka-u.ac.jp
RI Muraki, Isao/ACA-2312-2022
OI Ouyang, Meishuo/0000-0001-8781-1559
FU Grants-in-Aid for Scientific Research [21KK0168] Funding Source: KAKEN
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NR 46
TC 20
Z9 20
U1 0
U2 5
PU JAPAN ATHEROSCLEROSIS SOC
PI TOKYO
PA NICHINAI-KAIKAN B1, 3-28-8 HONGO BUNKYO-KU, TOKYO, 113-0033, JAPAN
SN 1340-3478
EI 1880-3873
J9 J ATHEROSCLER THROMB
JI J. Atheroscler. Thromb.
PY 2022
VL 29
IS 10
BP 1432
EP 1447
DI 10.5551/jat.63195
PG 16
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 5H1KH
UT WOS:000867444200001
PM 35082202
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Honicky, M
   Souza, JN
   Cardoso, SM
   Back, ID
   Vieira, FGK
   Hinnig, PD
   Moreno, YMF
AF Honicky, Michele
   Souza, Juliana Nicolodi
   Cardoso, Silvia Meyer
   de Carlos Back, Isabela
   Vieira, Francilene Gracieli Kunradi
   de Fragas Hinnig, Patricia
   Moreno, Yara Maria Franco
TI Dietary patterns are associated with central adiposity and carotid
   intima-media thickness in children and adolescents with congenital heart
   disease
SO EUROPEAN JOURNAL OF NUTRITION
LA English
DT Article
DE Dietary patterns; Principal component analysis; Atherosclerosis;
   Cardiovascular disease risk factors; Congenital heart disease
ID CARDIOVASCULAR-DISEASE; EUROPEAN CHILDREN; LIFE-STYLE; METABOLIC
   SYNDROME; OXIDATIVE STRESS; BODY-COMPOSITION; RISK-FACTORS; AMERICAN;
   PREVENTION; STATEMENT
AB Purpose Unhealthy dietary patterns (DP) in childhood are associated with cardiovascular disease in adulthood. DP in children and adolescents with congenital heart disease (CHD) are unknown. The aims of this study were to describe DPs of children and adolescents with CHD and to evaluate their associations with central adiposity, high-sensitivity C-reactive protein (hs-CRP) and carotid intima-media thickness (cIMT). Methods A cross-sectional study including 232 children and adolescents with CHD. Dietary data were based on three 24-h dietary recalls. Central adiposity was evaluated by waist circumference. hs-CRPs were determined by nephelometry. The cIMT was measured using ultrasound. DPs were identified using principal component analysis. Data were examined using logistic and linear regressions. Results Six DPs were identified. In multivariable-adjusted analysis, unhealthy DP (high intake of poultry, red meat, cold cuts and processed meats, soft drinks and sweetened beverages) and healthy DP (high intake of fish, eggs, bread, beans, tubers and roots, fruit and fruit juice) were associated with increased and decreased odds of central adiposity, respectively (Odds ratio (OR): 2.10; 95% confidence interval (95% CI) 1.09; 4.02; OR: 0.48 95% CI 0.24; 0.93). Besides, low-fat dairy DP (high intake of low-fat milk and dairy, mixed dishes, ultra-processed breads, candy and chocolate) was inversely associated with cIMT (beta: - 0.024; 95% CI - 0.04; - 0.01). Conclusion Unhealthy DP seems to increase the risk of central adiposity, while the healthy DP seems to decrease the risk of central adiposity. Still, low-fat dairy DP was inversely associated with cIMT. These findings may be helpful to develop nutrition recommendations for early cardiovascular disease prevention in children and adolescents with CHD.
C1 [Honicky, Michele; Vieira, Francilene Gracieli Kunradi; de Fragas Hinnig, Patricia; Moreno, Yara Maria Franco] Univ Fed Santa Catarina, Postgrad Program Nutr, Hlth Sci Ctr, Florianopolis, SC, Brazil.
   [Souza, Juliana Nicolodi] Univ Fed Santa Catarina, Hlth Sci Ctr, Undergrad Nutr Course, Florianopolis, SC, Brazil.
   [Cardoso, Silvia Meyer] Univ Fed Santa Catarina, Hosp Univ Polydoro Ernanni de Sao Tiago, Florianopolis, SC, Brazil.
   [Cardoso, Silvia Meyer; de Carlos Back, Isabela] Univ Fed Santa Catarina, Postgrad Program Publ Hlth, Hlth Sci Ctr, Florianopolis, SC, Brazil.
   [Vieira, Francilene Gracieli Kunradi; de Fragas Hinnig, Patricia; Moreno, Yara Maria Franco] Univ Fed Santa Catarina, Dept Nutr, Hlth Sci Ctr, Florianopolis, SC, Brazil.
C3 Universidade Federal de Santa Catarina (UFSC); Universidade Federal de
   Santa Catarina (UFSC); Universidade Federal de Santa Catarina (UFSC);
   Universidade Federal de Santa Catarina (UFSC); Universidade Federal de
   Santa Catarina (UFSC)
RP Moreno, YMF (corresponding author), Univ Fed Santa Catarina, Postgrad Program Nutr, Hlth Sci Ctr, Florianopolis, SC, Brazil.; Moreno, YMF (corresponding author), Univ Fed Santa Catarina, Dept Nutr, Hlth Sci Ctr, Florianopolis, SC, Brazil.
EM yara.moreno@ufsc.br
RI Hinnig, Patricia/Q-4262-2018; Franco Moreno, Yara Maria/E-6329-2014;
   Vieira, Francilene Gracieli Kunradi/KGK-8532-2024
OI Franco Moreno, Yara Maria/0000-0002-4983-2911; Meyer Cardoso,
   Silvia/0000-0003-2773-0815; Vieira, Francilene Gracieli
   Kunradi/0000-0003-4211-9133; Nicolodi Souza,
   Juliana/0000-0002-8094-3310; hinnig, patricia/0000-0002-9348-8513
FU Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior-Brasil
   (CAPES) [001]
FX This study was financed in part by the Coordenacao de Aperfeicoamento de
   Pessoal de Nivel Superior-Brasil (CAPES)-Finance Code 001.
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NR 52
TC 7
Z9 8
U1 0
U2 9
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1436-6207
EI 1436-6215
J9 EUR J NUTR
JI Eur. J. Nutr.
PD DEC
PY 2021
VL 60
IS 8
BP 4295
EP 4306
DI 10.1007/s00394-021-02586-0
EA MAY 2021
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA WS2TS
UT WOS:000653610300001
PM 34031710
DA 2025-06-11
ER

PT J
AU Kurhaluk, N
AF Kurhaluk, Natalia
TI Alcohol and melatonin
SO CHRONOBIOLOGY INTERNATIONAL
LA English
DT Article
DE Pathogenesis of alcoholism; chronobiological effects; melatonin;
   neurological and mental disorders; circadian rhythms; liver conditions;
   mitochondria; alcohol withdrawal syndrome
ID WITHDRAWAL; DEPENDENCE; EXPRESSION; WORK
AB Investigation of the pathogenesis of alcoholism in humans using different methodological approaches has facilitated detection of important biological factors of consequent metabolic diseases, endocrine disorders, and other medical conditions, such as alcoholic cardiomyopathy, alcoholic hypertension, heart and vascular lesions, alcoholic liver disease, alcoholic pancreatitis, etc. Alcohol abuse leads to damage to the nervous system, which can result in neurological and mental disorders, including alcoholic polyneuropathy, psychosis, and alcohol dementia. The complexity and versatility of the harmful effects of regular alcohol consumption on the human body can be considered in the perspective of a chronobiological approach, because alcohol is chronotoxic to biological processes. As a rhythm regulator, melatonin exerts a wide range of different effects: circadian rhythm regulation, thermoregulation, sleep induction, antioxidant, immunomodulatory, and anti-stress ones. This review presents from a chronobiological perspective the impact of melatonin on alcohol intoxication in terms of mental disorders, sleep and inflammation, hepatic injury, and mitochondrial function. It discusses the main clinical effects of melatonin on alcohol injury and the main targets as a therapy for alcohol disorders. Chronobiological effects of ethanol are related to melatonin suppression that has been associated with, among others, cancer risk. Exogenous melatonin seems to be a promising hepato- and immune-protector due to its antioxidant and anti-inflammatory properties, which in combination with other medicines makes it useful to prevent alcoholic organ damage. The reason for the scientific interest in melatonin as a treatment for alcoholism is obvious; the number of cases of this pathology that gives rise to metabolic syndrome, and its subsequent transformation into steatohepatitis, liver fibrosis, and cirrhosis, is increasing worldwide. Melatonin not only exerts antioxidant effects but it exerts various other effects contributing to the management of liver conditions. This review discusses the interaction between normal and pathological processes caused by alcohol consumption and the relationship between alcohol and melatonin in these conditions.
C1 [Kurhaluk, Natalia] Pomeranian Univ Slupsk, Inst Biol & Earth Sci, Dept Biol, Slupsk, Poland.
RP Kurhaluk, N (corresponding author), Pomeranian Univ Slupsk, Inst Biol & Earth Sci, Dept Physiol, Arciszewskiego 22b Str, PL-76200 Slupsk, Poland.
EM natalia.kurhaluk@apsl.edu.pl
OI Kurhaluk, Natalia/0000-0002-4669-1092
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NR 138
TC 13
Z9 13
U1 4
U2 8
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 0742-0528
EI 1525-6073
J9 CHRONOBIOL INT
JI Chronobiol. Int.
PD JUN 3
PY 2021
VL 38
IS 6
BP 785
EP 800
DI 10.1080/07420528.2021.1899198
EA MAR 2021
PG 16
WC Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Life Sciences & Biomedicine - Other Topics; Physiology
GA SF4SR
UT WOS:000632720100001
PM 33761823
DA 2025-06-11
ER

PT J
AU Hill, MA
   Jaisser, F
   Sowers, JR
AF Hill, Michael A.
   Jaisser, Frederic
   Sowers, James R.
TI Role of the vascular endothelial sodium channel activation in the
   genesis of pathologically increased cardiovascular stiffness
SO CARDIOVASCULAR RESEARCH
LA English
DT Review
DE Cardiovascular stiffness; Endothelium Na+ channel; Mineralocorticoid
   receptor; Insulin; Aldosterone; Signalling
ID MINERALOCORTICOID RECEPTOR ACTIVATION; SMOOTH-MUSCLE-CELL; SENSING ION
   CHANNELS; ARTERIAL STIFFNESS; DIASTOLIC DYSFUNCTION; INSULIN-RESISTANCE;
   ANGIOTENSIN-II; ALDOSTERONE PRODUCTION; METABOLIC SYNDROME; AORTIC
   STIFFNESS
AB Cardiovascular (CV) stiffening represents a complex series of events evolving from pathological changes in individual cells of the vasculature and heart which leads to overt tissue fibrosis. While vascular stiffening occurs naturally with ageing it is accelerated in states of insulin (INS) resistance, such as obesity and type 2 diabetes. CV stiffening is clinically manifested as increased arterial pulse wave velocity and myocardial fibrosis-induced diastolic dysfunction. A key question that remains is how are these events mechanistically linked. In this regard, heightened activation of vascular mineralocorticoid receptors (MR) and hyperinsulinaemia occur in obesity and INS resistance states. Further, a downstream mediator of MR and INS receptor activation, the endothelial cell Na+ channel (EnNaC), has recently been identified as a key molecular determinant of endothelial dysfunction and CV fibrosis and stiffening. Increased activity of the EnNaC results in a number of negative consequences including stiffening of the cortical actin cytoskeleton in endothelial cells, impaired endothelial NO release, increased oxidative stress-meditated NO destruction, increased vascular permeability, and stimulation of an inflammatory environment. Such endothelial alterations impact vascular function and stiffening through regulation of vascular tone and stimulation of tissue remodelling including fibrosis. In the case of the heart, obesity and INS resistance are associated with coronary vascular endothelial stiffening and associated reductions in bioavailable NO leading to heart failure with preserved systolic function (HFpEF). After a brief discussion on mechanisms leading to vascular stiffness per se, this review then focuses on recent findings regarding the role of INS and aldosterone to enhance EnNaC activity and associated CV stiffness in obesity/INS resistance states. Finally, we discuss how coronary artery-mediated EnNaC activation may lead to cardiac fibrosis and HFpEF, a condition that is especially pronounced in obese and diabetic females.
C1 [Hill, Michael A.; Sowers, James R.] Univ Missouri, Dalton Cardiovasc Res Ctr, Columbia, MO 65211 USA.
   [Hill, Michael A.; Sowers, James R.] Univ Missouri, Dept Med Pharmacol & Physiol, Sch Med, 134 Res Pk Dr, Columbia, MO 65212 USA.
   [Jaisser, Frederic] Univ Paris, Sorbonne Univ, Ctr Rech Cordeliers, INSERM, F-75006 Paris, France.
   [Sowers, James R.] Univ Missouri, Diabet & Cardiovasc Ctr, Sch Med, Columbia, MO 65212 USA.
   [Sowers, James R.] Univ Missouri, Dept Med, Sch Med, Columbia, MO 65212 USA.
C3 University of Missouri System; University of Missouri Columbia;
   University of Missouri System; University of Missouri Columbia;
   Universite Paris Cite; Sorbonne Universite; Institut National de la
   Sante et de la Recherche Medicale (Inserm); University of Missouri
   System; University of Missouri Columbia; University of Missouri System;
   University of Missouri Columbia
RP Hill, MA; Sowers, JR (corresponding author), Univ Missouri, Dalton Cardiovasc Res Ctr, Columbia, MO 65211 USA.; Hill, MA; Sowers, JR (corresponding author), Univ Missouri, Dept Med Pharmacol & Physiol, Sch Med, 134 Res Pk Dr, Columbia, MO 65212 USA.; Sowers, JR (corresponding author), Univ Missouri, Diabet & Cardiovasc Ctr, Sch Med, Columbia, MO 65212 USA.; Sowers, JR (corresponding author), Univ Missouri, Dept Med, Sch Med, Columbia, MO 65212 USA.
EM hillmi@missouri.edu; sowersj@health.missouri.edu
FU Heart, Lung and Blood Institute, National Institutes of Health, USA;
   Fight-HF Avenir Investment Program [ANR-15RHUS-0004]; Fondation de
   France [00086498]
FX Work of the authors described in this manuscript was supported by
   funding from Heart, Lung and Blood Institute, National Institutes of
   Health, USA for M.A.H. and J.R.S. and the Fight-HF Avenir Investment
   Program (ANR-15RHUS-0004) and the Fondation de France (Cardio 00086498)
   for F.J.
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NR 143
TC 48
Z9 54
U1 2
U2 25
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0008-6363
EI 1755-3245
J9 CARDIOVASC RES
JI Cardiovasc. Res.
PD JAN
PY 2022
VL 118
IS 1
BP 130
EP 140
DI 10.1093/cvr/cvaa326
EA NOV 2020
PG 11
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA YH4MI
UT WOS:000743142600020
PM 33188592
OA Green Published
DA 2025-06-11
ER

PT J
AU Lee, SE
   Lee, YB
   Jun, JE
   Jin, SM
   Jee, JH
   Bae, JC
   Kim, JH
AF Lee, S. -E.
   Lee, Y. -B.
   Jun, J. E.
   Jin, S. -M.
   Jee, J. H.
   Bae, J. C.
   Kim, J. H.
TI Increment of serum bilirubin as an independent marker predicting
   new-onset type 2 diabetes mellitus in a Korean population
SO NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
LA English
DT Article
DE Bilirubin; Diabetes mellitus; type 2; Heme oxygenase-1
ID METABOLIC SYNDROME; OXIDATIVE STRESS; ANTIOXIDANT; RISK; PATHWAYS;
   DISEASE; CELLS; MEN
AB Background and aims: Several cross-sectional studies reported that serum bilirubin concentrations had an inverse association with type 2 diabetes mellitus (T2DM) prevalence. The aim of the current study was to investigate the relationship between percentage change in bilirubin levels (PCB) and incident risk of T2DM using a longitudinal model.
   Methods and results: 22,084 participants who received regular health check-ups between 2006 and 2012 were enrolled. Multivariable-adjusted Cox regression models were used to determine the hazard ratio (HR) of incident T2DM based on PCB. PCB was determined by subtracting baseline serum bilirubin level (BB) from the bilirubin level at the end of follow-up or a year before the last date of diagnosis, dividing by BB and multiplying by 100.
   Compared to non-diabetics, BB was lower in the diabetic group at the initial visit. There were 20,098 participants without T2DM at the initial visit; 1253 new cases occurred during follow-up. As PCB increased, T2DM incidence also increased (P < 0.001). After adjusting for confounders, the HR of incident T2DM in the highest PCB quartile was 2.08 (95% confidence interval [CI] 1.76 -2.46). This trend remained significant when PCB was analyzed as a continuous variable (HR for 1-SD increment, 1.25; 95% CI 1.19-1.31).
   Additional analysis comparing the rate of PCB during the follow-up period revealed that the serum bilirubin level of the Incident T2DM group increased before T2DM development and decreased rapidly thereafter compared to others (P < 0.001).
   Conclusions: Bilirubin level increment over time is associated with T2DM development. (C) 2016 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.
C1 [Lee, S. -E.; Lee, Y. -B.; Jun, J. E.; Jin, S. -M.; Kim, J. H.] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Div Endocrinol & Metab,Dept Med, 81 Irwon Ro, Seoul 06351, South Korea.
   [Jee, J. H.] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Ctr Hlth Promot, Seoul, South Korea.
   [Bae, J. C.] Sungkyunkwan Univ, Sch Med, Samsung Changwon Hosp, Div Endocrinol & Metab,Dept Med, Chang Won, South Korea.
C3 Sungkyunkwan University (SKKU); Samsung Medical Center; Sungkyunkwan
   University (SKKU); Samsung Medical Center; Sungkyunkwan University
   (SKKU); Samsung Medical Center
RP Kim, JH (corresponding author), Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Div Endocrinol & Metab,Dept Med, 81 Irwon Ro, Seoul 06351, South Korea.
EM jaehyeonkim26@gmail.com
OI Jee, Jae Hwan/0000-0002-2716-9792
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NR 30
TC 6
Z9 6
U1 0
U2 6
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0939-4753
EI 1590-3729
J9 NUTR METAB CARDIOVAS
JI Nutr. Metab. Carbiovasc. Dis.
PD MAR
PY 2017
VL 27
IS 3
BP 234
EP 240
DI 10.1016/j.numecd.2016.10.003
PG 7
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism; Nutrition
   & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism;
   Nutrition & Dietetics
GA EP1EH
UT WOS:000397127700006
PM 27989511
DA 2025-06-11
ER

PT J
AU Doostvandi, T
   Bahadoran, Z
   Mozaffari-Khosravi, H
   Tahmasebinejad, Z
   Mirmiran, P
   Azizi, F
AF Doostvandi, Tayebeh
   Bahadoran, Zahra
   Mozaffari-Khosravi, Hassan
   Tahmasebinejad, Zhaleh
   Mirmiran, Parvin
   Azizi, Fereidoun
TI The association of dietary patterns and the incidence of insulin
   resistance after a 3-year follow-up: Tehran Lipid and Glucose Study
SO ASIA PACIFIC JOURNAL OF CLINICAL NUTRITION
LA English
DT Article
DE insulin; insulin resistance; type 2 diabetes; dietary pattern; principal
   component analysis
ID METABOLIC SYNDROME; CARDIOVASCULAR RISK; DIABETES-MELLITUS; OXIDATIVE
   STRESS; POPULATION; INDIVIDUALS; SENSITIVITY; COMPONENTS; INCREASES;
   EXERCISE
AB Background and Objectives: The aim of this study was to investigate the relationship between major dietary patterns and the risk of insulin resistance (IR) among an urban Iranian population. Methods and Study design: In this longitudinal study, 802 adult men and women were studied within the framework of Tehran Lipid and Glucose Study. Fasting serum insulin and glucose were measured at baseline and again after a 3-year of follow-up. The usual dietary intakes were assessed using a validated 168 item semi-quantitative food frequency questionnaire and major dietary patterns were obtained using principal component analysis. Logistic regression models were used to estimate the occurrence of IR across tertiles of dietary patterns with adjustment for potential confounding variables. Results: Mean age of participants was 39.0 +/- 11.2 years and 45.5% were men. Three major dietary patterns including the Western, traditional and healthy were extracted, which explained 25.3% of total variance in food intake. The healthy dietary pattern, loaded heavily on intake of vegetable oils, fresh and dried fruits, low-fat dairy, nuts and seeds, was accompanied with a reduced risk of insulin resistance by 51% (OR=0.49, 95% CI=0.30-0.81), and 81% (OR=0.19, 95% CI=0.10-0.36), in the second and third tertile, respectively (p trend=0.001). In the presence of all dietary pattern scores in the logistic regression model, a 45% reduced risk of IR was observed per 1 unit increase in healthy dietary pattern score. Conclusion: These findings confirmed the protective effect of a plant-based, low-fat dietary pattern against the development of insulin resistance as a main risk factor of type 2 diabetes and metabolic disorders.
C1 [Doostvandi, Tayebeh] Shahid Sadoghi Univ Med Sci, Int Campuse, Yazd, Iran.
   [Bahadoran, Zahra; Tahmasebinejad, Zhaleh; Mirmiran, Parvin] Shahid Beheshti Univ Med Sci, Res Inst Endocrine Sci, Nutr & Endocrine Res Ctr, 24 Shahid Erabi St,Yeman St, Tehran, Iran.
   [Mozaffari-Khosravi, Hassan] Shahid Sadoghi Univ Med Sci, Dept Nutr, Yazd, Iran.
   [Azizi, Fereidoun] Shahid Beheshti Univ Med Sci, Res Inst Endocrine Sci, Endocrine Res Ctr, Tehran, Iran.
C3 Shahid Beheshti University Medical Sciences; Shahid Beheshti University
   Medical Sciences
RP Mirmiran, P (corresponding author), Shahid Beheshti Univ Med Sci, Res Inst Endocrine Sci, Nutr & Endocrine Res Ctr, 24 Shahid Erabi St,Yeman St, Tehran, Iran.
EM mirmiran@endocrine.ac.ir
RI Bahadoran, Zahra/V-2003-2019; Mozaffari-khosravi, Hassan/A-4359-2009;
   Mirmiran, Parvin/V-1433-2019; Azizi, Fereidoun/ABD-4136-2021
OI Mirmiran, Parvin/0000-0003-2391-4924; Azizi,
   Fereidoun/0000-0002-6470-2517
FU Research Institute for Endocrine Sciences, Shahid Beheshti University of
   Medical Sciences [0409/3451]
FX We thank the study participants and the field investigators of the
   Tehran Lipid and Glucose Study for their cooperation and assistance in
   physical examinations, biochemical and nutritional evaluation and
   database management. This study, as part of MSc. thesis of Ms Tayebeh
   Doostvandi, was supported by Research Institute for Endocrine Sciences,
   Shahid Beheshti University of Medical Sciences (Registration NO.
   0409/3451). We would like to acknowledge Ms N Shiva for critical editing
   of English grammar and syntax of the manuscript.
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NR 35
TC 10
Z9 10
U1 0
U2 7
PU H E C PRESS, HEALTHY EATING CLUB PTY LTD
PI MCKINNON
PA PO BOX 4121, MCKINNON, VIC 3204, AUSTRALIA
SN 0964-7058
EI 1440-6047
J9 ASIA PAC J CLIN NUTR
JI Asia Pac. J. Clin. Nutr.
PY 2017
VL 26
IS 3
BP 531
EP 538
DI 10.6133/apjcn.032016.12
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA ET2SR
UT WOS:000400124900021
PM 28429920
DA 2025-06-11
ER

PT J
AU Chen, CM
   Zhang, W
   Shi, HF
   Zhuo, YJ
   Yang, G
   Zhang, AH
   Hou, YY
   Tan, RX
   Li, EG
AF Chen, Changmai
   Zhang, Wei
   Shi, Hengfei
   Zhuo, Yujie
   Yang, Guang
   Zhang, Aihua
   Hou, Yayi
   Tan, Ren Xiang
   Li, Erguang
TI A novel benzenediamine derivative FC98 reduces insulin resistance in
   high fat diet-induced obese mice by suppression of metaflammation
SO EUROPEAN JOURNAL OF PHARMACOLOGY
LA English
DT Article
DE Metaflammation; N-1-(4-fluorobenzyl)-4-methylbenzene-1; 2-diamine;
   Diet-induced obesity; Anit-inflammation
ID FACTOR-KAPPA-B; ADIPOSE-TISSUE; MOUSE MODEL; IKK-BETA; INFLAMMATION;
   CELLS; MACROPHAGES; STRESS; EXPRESSION; ACIDS
AB Chronic low-grade metabolic inflammation (metaflammation) is a hallmark of metabolic diseases. The aim of this study was to determine the effectiveness of a newly identified benzenediamine derivative (FC98, PubChem CID: 14989837) against metaflammation and insulin resistance using a high fat diet-induced obesity (DIO) murine model. LPS and free fatty acids (FFAs)-induced gene expression and signaling was determined in cell culture systems. Inflammasome activation was determined by measuring IL-1 beta release with ELISA. The in vivo activity was assayed in C57BL/6J mice fed with a high fat diet (RFD) by measuring body weight gains, glucose tolerance and insulin sensitivity. The effect was also evaluated by H&E and FRC staining, by measuring gene expression and cytokine production, and by analysis of F4/80(+)CD11bh macrophage infiltration. FC98 exhibited anti-inflammatory activity against LPS- and EFAs-induced IL-6, and TNF-alpha gene expression and JNK and p38 activation. The IC50 for FC98 to inhibit NO production was determined at 6.8 mu M. FC98 also dose-dependently inhibited IL-1 beta secretion. In DIO mice, FC98 at 10 and 20 mg/kg significantly improved metabolic parameters, including body weight, fat mass, glucose disposal and insulin sensitivity. The reduction in adipocyte area, F4/80(+)CD11b(+) macrophage infiltration, proinflammatory gene expression, along with JNK activation, was also significant in those groups. Additionally, FC98-treated animals had increased Ala phosphorylation in response to insulin stimulation. FC98 inhibits metaflammation and ameliorates insulin resistance mainly by inhibiting signaling pathways of proinflammatory response in DIO animals. This study highlights the significance of targeting metaflammation for obesity-attributive metabolic syndrome. (C) 2015 Elsevier B.V. All rights reserved.
C1 [Chen, Changmai; Zhang, Wei; Shi, Hengfei; Zhang, Aihua; Hou, Yayi; Tan, Ren Xiang; Li, Erguang] Nanjing Univ, Sch Med, Nanjing 210093, Jiangsu, Peoples R China.
   [Chen, Changmai; Zhang, Wei; Shi, Hengfei; Zhang, Aihua; Hou, Yayi; Tan, Ren Xiang; Li, Erguang] Nanjing Univ, State Key Lab Pharmaceut Biotechnol, Nanjing 210093, Jiangsu, Peoples R China.
   [Chen, Changmai; Zhang, Wei; Shi, Hengfei; Yang, Guang; Hou, Yayi; Li, Erguang] Nanjing Univ, Sch Med, Jiangsu Lab Mol Med, Nanjing 210093, Jiangsu, Peoples R China.
   [Chen, Changmai; Zhang, Aihua; Tan, Ren Xiang] Nanjing Univ, Coll Life Sci, Nanjing 210093, Jiangsu, Peoples R China.
   [Zhuo, Yujie; Yang, Guang] Nanjing Med Univ, Nanjing Childrens Hosp, Nanjing, Jiangsu, Peoples R China.
C3 Nanjing University; Nanjing University; Nanjing University; Nanjing
   University; Nanjing Medical University
RP Li, EG (corresponding author), Nanjing Univ, Sch Med, 22 Hankou Rd, Nanjing 210093, Jiangsu, Peoples R China.
EM erguang@nju.edu.cn
RI Zhang, Wei/HLW-0007-2023; Zhang, Aihua/HGD-2250-2022; Chen,
   Changmai/Q-4017-2019; yang, guangmin/GVU-0745-2022; Chen,
   Changmai/D-1259-2016
OI Chen, Changmai/0000-0001-5755-1856; yang, guangmin/0000-0002-3356-0034;
   Zhang, Wei/0000-0003-1928-5758; Chen, Changmai/0000-0002-8372-0331
FU National Natural Science Foundation of China, China [NSFC 81421091,
   81371772]; Nanjing Bureau of Science and Technology [ZKX130391]
FX This work was financially supported by grants from the National Natural
   Science Foundation of China, China (NSFC 81421091, 81371772) and from
   the Nanjing Bureau of Science and Technology (ZKX130391).
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NR 47
TC 5
Z9 6
U1 0
U2 22
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0014-2999
EI 1879-0712
J9 EUR J PHARMACOL
JI Eur. J. Pharmacol.
PD AUG 15
PY 2015
VL 761
BP 298
EP 308
DI 10.1016/j.ejphar.2015.06.021
PG 11
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA CO5VT
UT WOS:000359227300039
PM 26086863
DA 2025-06-11
ER

PT J
AU Lu, J
   Wen, YX
   Zhang, L
   Zhang, C
   Zhong, WH
   Zhang, L
   Yu, Y
   Chen, LB
   Xu, D
   Wang, H
AF Lu, Juan
   Wen, Yinxian
   Zhang, Li
   Zhang, Chong
   Zhong, Weihua
   Zhang, Lu
   Yu, Ying
   Chen, Liaobin
   Xu, Dan
   Wang, Hui
TI Prenatal ethanol exposure induces an intrauterine programming of
   enhanced sensitivity of the hypothalamic-pituitary-adrenal axis in
   female offspring rats fed with post-weaning high-fat diet
SO TOXICOLOGY RESEARCH
LA English
DT Article
ID CORTICOTROPIN-RELEASING HORMONE; GLUCOCORTICOID-RECEPTOR GENE;
   PARAVENTRICULAR NUCLEUS; GROWTH-RETARDATION; HPA AXIS; DEVELOPMENTAL
   ORIGINS; STRESS INTEGRATION; METABOLIC SYNDROME; FOOD RESTRICTION;
   ALCOHOL EXPOSURE
AB Our previous study demonstrated that prenatal ethanol exposure (PEE) enhances the sensitivity of the hypothalamic-pituitary-adrenal (HPA) axis in adult offspring rats. This study aims to investigate the underlying mechanism. PEE treated female offspring rats were fed with high-fat diet and subjected to the unpredictable chronic stresses (UCS) in adulthood. For adult offspring, the PEE group exhibited increased expression of hypothalamic corticotrophin-releasing hormone (CRH) and arginine vasopressin (AVP) as well as elevated gain rates of serum adrenocorticotropic hormone (ACTH) and corticosterone after UCS. Meanwhile, PEE significantly decreased the expression of glutamic acid decarboxylase 65 (GAD65) and Reelin (Reln), and the expression ratio of hypothalamic vesicular glutamate transporter 2 (VGluT2)/GAD65 was enhanced in the adult PEE offspring. These changes were also accompanied by the enhanced expression of glucocorticoid receptor (GR), N-methyl-D-aspartate-subtype glutamate receptor 2B and the decreased expression ratio of mineralocorticoid receptor (MR)/GR in the hippocampus. Furthermore, the abnormal hippocampus neurons were observed especially in the cornu ammonis 3 (CA3) and dentate gyrus subfields. For fetuses, PEE significantly decreased the expression of mammalian achaete-scute homolog-1 (Mash1) as well as GAD65 and Reln. Both VGluT2/GAD65 expression ratio and GR expression were increased while the MR/GR expression ratio was decreased in the PEE group. PEE also caused ultrastructural injury in CA3. Our findings suggest that PEE causes the persistent remodeling alterations of impaired morphology and decreased MR/GR expression ratio in the hippocampus, as well as the imbalanced glutamatergic/GABAergic afferent inputs in the hypothalamus. All of these would contribute to the enhanced sensitivity of the HPA axis in adult offspring.
C1 [Lu, Juan; Zhang, Li; Zhang, Chong; Zhong, Weihua; Zhang, Lu; Yu, Ying; Xu, Dan; Wang, Hui] Wuhan Univ, Basic Med Sch, Dept Pharmacol, Wuhan 430071, Peoples R China.
   [Wen, Yinxian; Chen, Liaobin] Wuhan Univ, Zhongnan Hosp, Dept Orthoped Surg, Wuhan 430071, Peoples R China.
   [Xu, Dan; Wang, Hui] Hubei Prov Key Lab Dev Originated Dis, Wuhan 430071, Peoples R China.
   [Lu, Juan] Hubei Univ Med, Basic Med Sch, Dept Pharmacol, Shiyan 442000, Peoples R China.
C3 Wuhan University; Wuhan University; Hubei University of Medicine
RP Lu, J (corresponding author), Wuhan Univ, Basic Med Sch, Dept Pharmacol, Wuhan 430071, Peoples R China.
EM xuyidan70188@whu.edu.cn; wanghui19@whu.edu.cn
RI Zhang, Lu/MIT-9461-2025; lu, juan/MEP-8121-2025
FU National Natural Science Foundation of China [81220108026, 81430089,
   81300984, 81371483]; Key Grant Project of the Chinese Ministry of
   Education [V200801]; National Science & Technology Pillar Program of
   China [2013BAI12B01-3]
FX This work was supported by grants from the National Natural Science
   Foundation of China (No. 81220108026, 81430089, 81300984, 81371483), the
   Key Grant Project of the Chinese Ministry of Education (No. V200801) and
   the National Science & Technology Pillar Program of China (No.
   2013BAI12B01-3).
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NR 78
TC 3
Z9 4
U1 3
U2 19
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2045-452X
EI 2045-4538
J9 TOXICOL RES-UK
JI Toxicol. Res.
PY 2015
VL 4
IS 5
BP 1238
EP 1249
DI 10.1039/c5tx00012b
PG 12
WC Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Toxicology
GA CP7FG
UT WOS:000360052000010
OA Bronze
DA 2025-06-11
ER

PT J
AU Leung, CW
   Epel, ES
   Ritchie, LD
   Crawford, PB
   Laraia, BA
AF Leung, Cindy W.
   Epel, Elissa S.
   Ritchie, Lorrene D.
   Crawford, Patricia B.
   Laraia, Barbara A.
TI Food Insecurity Is Inversely Associated with Diet Quality of
   Lower-Income Adults
SO JOURNAL OF THE ACADEMY OF NUTRITION AND DIETETICS
LA English
DT Article
DE Alternate Healthy Eating Index-2010; Dietary intake; Food insecurity;
   Healthy Eating Index-2005
ID SUGAR-SWEETENED BEVERAGES; CHRONIC STRESS; METABOLIC SYNDROME;
   HEART-DISEASE; WEIGHT STATUS; OBESITY; HEALTH; CHILDREN; RISK;
   AVAILABILITY
AB Food insecurity acts as a chronic stressor independent of poverty. Food-insecure adults may consume more highly palatable foods as a coping mechanism, leading to poorer diet quality and increased risks of chronic disease over time. Using data from the 19992008 National Health and Nutrition Examination Surveys, this study aimed to examine the cross-sectional differences in dietary intake and diet quality by household food security among 8,129 lower-income adults (<= 300% of the federal poverty level). Food insecurity was assessed using the 18-item US Household Food Security Survey Module. Dietary intake was assessed from 24-hour recalls and diet quality was measured using the Healthy Eating Index-2005 and the Alternate Healthy Eating Index-2010. Relative mean differences in dietary outcomes by household food security were estimated using linear regression models, adjusting for sociodemographic characteristics. Lower-income food-insecure adults reported higher consumption of some highly palatable foods, including high-fat dairy products (P trend<0.0001) and salty snacks (P trend=0.01) compared with lower-income food-secure adults. Food insecurity was also associated with more sugar-sweetened beverages (P trend=0.003); more red/processed meat (P trend=0.005); more nuts, seeds, and legumes (P trend=0.0006); fewer vegetables (P trend<0.0001); and fewer sweets and bakery desserts (P trend=0.0002). No differences were observed for intakes of total energy and macronutrients. Food insecurity was significantly associated with lower Healthy Eating Index-2005 (P trend<0.0001) and Alternate Healthy Eating Index-2010 scores (P trend<0.0001). Despite no macronutrient differences, food insecurity was associated with characteristics of poor diet quality known to increase chronic disease risk.
C1 [Leung, Cindy W.; Epel, Elissa S.] Univ Calif San Francisco, Sch Med, Ctr Hlth & Community, San Francisco, CA 94118 USA.
   [Epel, Elissa S.] Univ Calif San Francisco, Dept Psychiat, San Francisco, CA 94118 USA.
   [Ritchie, Lorrene D.] Univ Calif Berkeley, Nutr Policy Inst, Div Agr & Nat Resources, Berkeley, CA 94720 USA.
   [Crawford, Patricia B.] Univ Calif Berkeley, Dr Robert C & Veronica Atkins Ctr Weight & Hlth, Berkeley, CA 94720 USA.
   [Laraia, Barbara A.] Univ Calif Berkeley, Sch Publ Hlth, Berkeley, CA 94720 USA.
C3 University of California System; University of California San Francisco;
   University of California System; University of California San Francisco;
   University of California System; University of California Berkeley;
   University of California System; University of California Berkeley;
   University of California System; University of California Berkeley
RP Leung, CW (corresponding author), Univ Calif San Francisco, Ctr Hlth & Community, 3333 Calif St,Suite 465, San Francisco, CA 94118 USA.
EM cindyleung@post.harvard.edu
RI Laraia, Barbara/GXG-1829-2022; Epel, Elissa/ABI-6703-2022
FU University of California Multicampus Research Program and Initiative
   [142691]
FX C. W. Leung was supported by grant no. 142691 from the University of
   California Multicampus Research Program and Initiative.
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NR 55
TC 390
Z9 492
U1 3
U2 100
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 2212-2672
EI 2212-2680
J9 J ACAD NUTR DIET
JI J. Acad. Nutr. Diet.
PD DEC
PY 2014
VL 114
IS 12
BP 1943
EP U329
DI 10.1016/j.jand.2014.06.353
PG 13
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nutrition & Dietetics
GA AU4FK
UT WOS:000345565100010
PM 25091796
DA 2025-06-11
ER

PT J
AU Roh, SJ
   Kim, HN
   Shim, U
   Kim, BH
   Kim, SJ
   Chung, HW
   Lee, H
   Sung, YA
   Kim, HL
AF Roh, Seung-Ju
   Kim, Han-Na
   Shim, Unjin
   Kim, Bo-Hye
   Kim, Su-Jin
   Chung, Hye Won
   Lee, Hyejin
   Sung, Yeon-Ah
   Kim, Hyung-Lae
TI Association between Blood Lipid Levels and Personality Traits in Young
   Korean Women
SO PLOS ONE
LA English
DT Article
ID DENSITY-LIPOPROTEIN-CHOLESTEROL; BODY-MASS INDEX; 5 FACTOR MODEL;
   METABOLIC SYNDROME; PHYSICAL-ACTIVITY; PLANNED BEHAVIOR;
   NATIONAL-HEALTH; 5-FACTOR MODEL; HOSTILITY; DISEASE
AB Abnormal lipid levels are important etiological factors associated with the development of atherosclerosis and with increased cardiovascular morbidity and mortality. Lipid levels are also influenced by lifestyle and behavioral factors, which suggests that personality traits might be related to abnormal lipid profiles. Studies on personality traits and lipid levels are relatively scarce in Korea. Therefore, the objective of this study was to examine the association between lipid levels and personality traits in young Korean women. A total of 1,701 young Korean women [mean age = 24.9 +/- 4.6 years (range 17-39)] who volunteered for personality trait evaluation were recruited for this study. Lipid levels, including total cholesterol, high density lipoprotein (HDL) cholesterol, and triglyceride, were measured in all subjects after an overnight fast, and a low density lipoprotein (LDL) cholesterol level was calculated. The study population was divided into abnormal and normal lipid level groups according to the clinical criteria. Personality traits were measured using the Revised NEO Personality Inventory for the Five-Factor Model of personality. High neuroticism was associated with low HDL cholesterol levels. Low extraversion and openness were associated with high levels of triglyceride. At the facet level, the association between personality and lipid levels were generally consistent. Angry hostility, self-consciousness, vulnerability to stress, activity, and straightforwardness were associated with HDL cholesterol levels. Activity, positive emotion, aesthetics, actions, and deliberation were associated with triglyceride. When applying clinical criteria, conscientiousness was less likely to have abnormal total cholesterol levels. Our results showed that the women with the low HDL cholesterol levels are like to be more neurotic and the hyperglycemic women are prone to lower extraversion and openness in Korea. Understanding the associations between blood lipid levels and personality traits may have a beneficial effect for the managing of dyslipidemia.
C1 [Roh, Seung-Ju; Kim, Han-Na; Kim, Bo-Hye; Kim, Su-Jin; Kim, Hyung-Lae] Ewha Womans Univ, Sch Med, Dept Biochem, Seoul, South Korea.
   [Shim, Unjin] Ewha Womans Univ, Med Ctr, Seoul Seonam Hosp, Dept Internal Med, Seoul, South Korea.
   [Chung, Hye Won; Lee, Hyejin; Sung, Yeon-Ah] Ewha Womans Univ, Sch Med, Seoul, South Korea.
C3 Ewha Womans University; Ewha Womans University; Ewha Womans University
RP Kim, HN (corresponding author), Ewha Womans Univ, Sch Med, Dept Biochem, Seoul, South Korea.
EM o147942@gmail.com; hyung@ewha.ac.kr
RI Kim, Kyoungmi/AEP-3965-2022; Kim, Sooyeon/AAA-8521-2022; Kim,
   Byung-Hak/AAY-9891-2020
FU Ministry of Education, Science, and Technology [NRF-2010-0026606,
   NRF-2014R1A2A2A04006291]; Basic Science Research Program through the
   National Research Foundation of Korea (NRF)
FX This research was supported by the Basic Science Research Program
   through the National Research Foundation of Korea (NRF), funded by the
   Ministry of Education, Science, and Technology (NRF-2010-0026606 and
   NRF-2014R1A2A2A04006291). The funders had no role in study design, data
   collection and analysis, decision to publish, or preparation of the
   manuscript.
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NR 52
TC 9
Z9 10
U1 0
U2 16
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD SEP 30
PY 2014
VL 9
IS 9
AR e108406
DI 10.1371/journal.pone.0108406
PG 8
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA AR6CW
UT WOS:000343671700091
PM 25268499
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Fayh, APT
   Lopes, AL
   Fernandes, PR
   Reischak-Oliveira, A
   Friedman, R
AF Trussardi Fayh, Ana Paula
   Lopes, Andre Luiz
   Fernandes, Pablo Rober
   Reischak-Oliveira, Alvaro
   Friedman, Rogerio
TI Impact of weight loss with or without exercise on abdominal fat and
   insulin resistance in obese individuals: a randomised clinical trial
SO BRITISH JOURNAL OF NUTRITION
LA English
DT Article
DE Weight loss; Diet; Physical training; Obese; Insulin resistance
ID C-REACTIVE PROTEIN; VISCERAL ADIPOSE-TISSUE; COMPUTED-TOMOGRAPHY;
   METABOLIC SYNDROME; PLASMA-CONCENTRATIONS; GLUCOSE-TOLERANCE;
   PHYSICAL-ACTIVITY; OXIDATIVE STRESS; HEALTHY-ADULTS; INFLAMMATION
AB Evidence supports an important contribution of abdominal obesity and inflammation to the development of insulin resistance (IR) and CVD. Weight loss in obese individuals can reduce inflammation and, consequently, IR, but the role of training remains unclear. The aim of this study was to evaluate the effects of body weight reduction with and without exercise over abdominal fat tissue (primary outcome) and IR. In this randomised clinical trial, forty-eight obese individuals (age 31.8 (SD 6.0) years, BMI 34.8 (SD 2.7) kg/m(2)) were randomised to either a diet-only group (DI) or a diet and exercise group (DI + EXE). Treatment was maintained until 5% of the initial body weight was lost. At baseline and upon completion, the following parameters were analysed: biochemical parameters such as glycaemia and insulin for the determination of homeostasis model assessment of insulin resistance (HOMA-IR), high-sensitivity C-reactive protein (hs-CRP) and abdominal computed tomography for the determination of visceral and subcutaneous adipose tissue. A total of thirteen individuals dropped out before completing the weight-loss intervention and did not repeat the tests. In both the DI (n 18) and DI + EXE (n 17) groups, we observed significant and similar decreases of visceral adipose tissue (difference between means: 7.9 (95% CI -9.5, 25.2) cm(2), P=0.36), hs-CRP (difference between means: -0.06 (95% CI -0.19, 0.03) mg/l, P=0.39) and HOMA (difference between means: -0.04 (95% CI -0.17, 0.08), P=0.53). In the present study, 5% weight loss reduced abdominal fat and IR in obese individuals and exercise did not add to the effect of weight loss on the outcome variables.
C1 [Trussardi Fayh, Ana Paula; Friedman, Rogerio] Univ Fed Rio Grande do Sul, Endocrine Unit, Hosp Clin Porto Alegre, Porto Alegre, RS, Brazil.
   [Trussardi Fayh, Ana Paula] Univ Fed Rio Grande do Norte, Hlth Sci Coll Trairi, BR-59200000 Santa Cruz, RN, Brazil.
   [Lopes, Andre Luiz; Fernandes, Pablo Rober; Reischak-Oliveira, Alvaro] Univ Fed Rio Grande do Sul, Sch Phys Educ, Exercise Res Lab, Porto Alegre, RS, Brazil.
C3 Hospital de Clinicas de Porto Alegre; Universidade Federal do Rio Grande
   do Sul; Universidade Federal do Rio Grande do Norte; Universidade
   Federal do Rio Grande do Sul
RP Fayh, APT (corresponding author), Univ Fed Rio Grande do Sul, Endocrine Unit, Hosp Clin Porto Alegre, Porto Alegre, RS, Brazil.
EM apfayh@yahoo.com.br
RI Lopes, Andre/AFO-3756-2022; Reischak-Oliveira, Alvaro/D-3278-2009;
   Friedman, Rogerio/H-9718-2012
OI Reischak-Oliveira, Alvaro/0000-0003-4590-2991; Friedman,
   Rogerio/0000-0003-2802-4242
FU Projeto de Nucleos de Excelencia do Ministerio de Ciencia e Tecnologia;
   Ministerio de Ciencia e Tecnologia; Conselho Nacional de Desenvolvimento
   Cientifico e Tecnologico; FIPE-Hospital de Clinicas de Porto Alegre
FX This work was supported by grants from the Projeto de Nucleos de
   Excelencia do Ministerio de Ciencia e Tecnologia, Ministerio de Ciencia
   e Tecnologia, Conselho Nacional de Desenvolvimento Cientifico e
   Tecnologico and FIPE-Hospital de Clinicas de Porto Alegre. The
   contributions of each author are as follows: A. P. T. F. designed and
   conducted the research, collected and analysed the data and wrote the
   paper. A. L. L. collected the data and assisted in writing the paper. P.
   R. F. assisted with data collection. A. R.-O. designed the research and
   wrote the paper. R. F. supervised the study, designed the research,
   analysed the data and wrote the paper. All authors declare that they
   have no conflicts of interest.
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NR 37
TC 34
Z9 38
U1 0
U2 26
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1145
J9 BRIT J NUTR
JI Br. J. Nutr.
PD AUG 14
PY 2013
VL 110
IS 3
BP 486
EP 492
DI 10.1017/S0007114512005442
PG 7
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 189OO
UT WOS:000322276800011
PM 23302544
OA Bronze
DA 2025-06-11
ER

PT J
AU Park, Y
   Booth, FW
   Lee, S
   Laye, MJ
   Zhang, CH
AF Park, Yoonjung
   Booth, Franki W.
   Lee, Sewon
   Laye, Mathew J.
   Zhang, Cuihua
TI Physical activity opposes coronary vascular dysfunction induced during
   high fat feeding in mice
SO JOURNAL OF PHYSIOLOGY-LONDON
LA English
DT Article
ID ENDOTHELIAL DYSFUNCTION; INSULIN-RESISTANCE; CARDIOVASCULAR-DISEASE;
   LEPTIN RESISTANCE; NITRIC-OXIDE; MICROVASCULAR DYSFUNCTION; METABOLIC
   SYNDROME; OXIDATIVE STRESS; EXERCISE; OBESITY
AB The study's purpose was to investigate if physical activity initiated with the start of high-fat feeding would oppose development of endothelial dysfunction, and if it does, then to determine some potential mechanisms. C57BL/6 female mice were randomly divided into three groups: (1) control low-fat diet (LF-SED; 15% of calories from fat), (2) high-fat diet (HF-SED; 45% of calories from fat), and (3) HF diet given access to a voluntary running wheel (HF-RUN). Our hypothesis was that HF-RUN would differ in multiple markers of endothelial dysfunction from HF-SED after 10 weeks of 45%-fat diet, but would not differ from LF-SED. HF-RUN differed from HF-SED in nine determinations in which HF-SED either had decreases in (1) acetylcholine (ACh)-induced and flow-induced vasodilatations in isolated, pressurized coronary arterioles, (2) heart phosphorylated endothelial nitric oxide synthase (p-eNOS/eNOS) protein, (3) coronary arteriole leptin (ob) receptor protein, (4) phosphorylated signal transducer and activator of transcription 3 (p-STAT3/STAT3) protein, and (5) coronary arteriole superoxide dismutase 1 protein; or had increases in (6) percentage body fat, (7) serum leptin, (8) coronary arteriole suppressor of cytokine signalling 3 (SOCS3) protein, and (9) coronary arteriole gp91phox protein. Higher endothelium-dependent vasodilatation by ACh or leptin was abolished with incubation of NOS inhibitor NG-nitro-l-arginine-methyl ester (l-NAME) in LF-SED and HF-RUN groups. Further, impaired ACh-induced vasodilatation in HF-SED was normalized by apocynin or TEMPOL to LF-SED and HF-RUN. These findings demonstrate multiple mechanisms (eNOS, leptin and redox balance) by which voluntary running opposes the development of impaired coronary arteriolar vasodilatation during simultaneous high-fat feeding.
C1 [Park, Yoonjung] Texas Tech Univ, Dept Hlth Exercise & Sports Sci, Lubbock, TX 79409 USA.
   [Park, Yoonjung; Lee, Sewon; Zhang, Cuihua] Univ Missouri, Dept Internal Med, Columbia, MO 65211 USA.
   [Booth, Franki W.; Lee, Sewon; Laye, Mathew J.; Zhang, Cuihua] Univ Missouri, Dept Med Pharmacol & Physiol, Columbia, MO 65211 USA.
   [Booth, Franki W.] Univ Missouri, Dept Nutr & Exercise Physiol, Columbia, MO 65211 USA.
   [Booth, Franki W.] Univ Missouri, Dept Biomed Sci, Columbia, MO 65211 USA.
   [Park, Yoonjung; Booth, Franki W.; Zhang, Cuihua] Univ Missouri, Dalton Cardiovasc Ctr, Columbia, MO 65211 USA.
C3 Texas Tech University System; Texas Tech University; University of
   Missouri System; University of Missouri Columbia; University of Missouri
   System; University of Missouri Columbia; University of Missouri System;
   University of Missouri Columbia; University of Missouri System;
   University of Missouri Columbia; University of Missouri System;
   University of Missouri Columbia
RP Park, Y (corresponding author), Texas Tech Univ, Dept Hlth Exercise & Sports Sci, BOX 43011, Lubbock, TX 79409 USA.
EM yoonjung.park@ttu.edu
RI Laye, Matthew/AAQ-1897-2020; Park, Yoonjung/LRU-1163-2024; Lee,
   Sewon/C-8432-2016
OI Lee, Sewon/0000-0002-6179-5156; Laye, Matthew/0000-0003-3214-3113
FU Pfizer [2004-37]; American Heart Association [110350047A]; NIH
   [RO1-HL077566]
FX This work was supported by grants from Pfizer Atorvastatin Research
   Award (2004-37), American Heart Association Scientist Development Grant
   (110350047A) and NIH grant (RO1-HL077566) to Dr Cuihua Zhang; and by
   gifts to Frank Booth. We acknowledge Mr Scott Naples for a support in
   monitoring of voluntary running and animal care. Nathan Jenkins and
   Jaume Padilla offered editorial comments.
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NR 62
TC 39
Z9 49
U1 0
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-3751
EI 1469-7793
J9 J PHYSIOL-LONDON
JI J. Physiol.-London
PD SEP
PY 2012
VL 590
IS 17
BP 4255
EP 4268
DI 10.1113/jphysiol.2012.234856
PG 14
WC Neurosciences; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Physiology
GA 996NI
UT WOS:000308095900016
PM 22674721
OA Green Published
DA 2025-06-11
ER

PT J
AU Rosenström, T
   Jokela, M
   Cloninger, CR
   Hintsanen, M
   Juonala, M
   Raitakari, O
   Viikari, J
   Keltikangas-Järvinen, L
AF Rosenstrom, Tom
   Jokela, Markus
   Cloninger, Claude Robert
   Hintsanen, Mirka
   Juonala, Markus
   Raitakari, Olli
   Viikari, Jorma
   Keltikangas-Jarvinen, Liisa
TI Associations between dimensional personality measures and preclinical
   atherosclerosis: The cardiovascular risk in Young Finns study
SO JOURNAL OF PSYCHOSOMATIC RESEARCH
LA English
DT Article
DE Personality; Atherosclerosis; Carotid intima-media thickness; Behavioral
   medicine; Multivariate analysis; Temperament and character
ID INTIMA-MEDIA THICKNESS; CORONARY-HEART-DISEASE; LARGE SOCIAL NETWORK;
   CAROTID-ARTERY; MYOCARDIAL-INFARCTION; DEPRESSIVE SYMPTOMS; METABOLIC
   SYNDROME; TEMPERAMENT; STRESS; HOSTILITY
AB Objective: To assess how multidimensional personality-trait theories, such as the Psychobiological Model of Temperament and Character, and the Five-factor Model of Personality, are associated with subclinical atherosclerosis as indicated by carotid intima-media thickness (IMT). The analysis was designed to tolerate nonlinear development in which the same personality profiles can have multiple final outcomes and different antecedent profiles can have the same final outcome.
   Methods: 605 men and 844 women (average age 31.6 year, s.d. = 5.0, range = 24-39) provided data on IMT and traits of the psychobiological model, 725 men and 1011 women were assessed for IMT and the five-factor model (age 37.7 year, s.d. = 5.0, range = 30-45). Robust multidimensional Hotelling's T-2 statistic was used to detect personality differences between participants with high IMT and others. Model-based clustering method further explored the effect.
   Results: Those with a high level of subclinical atherosclerosis within the sample (highest IMT-decile) had a combined higher persistence (i.e., were perseverative or perfectionistic), more disorganized (schizotypal) character, and more antisocial temperamental configuration than others (P = 0.019). No effect was found for the five-factor model (P = 0.978). Traditional methods that did not account for multidimensionality and nonlinearity did not detect an association.
   Conclusion: Psychological well-being may have positive effects on health that reduce atherosclerosis in the population as a whole. Increased subclinical atherosclerosis was associated with a profile that combines known risk factors, such as cynical distrust and hostile tendencies. More frequent use of statistical procedures that can cope with non-linear interactions in complex psychobiological systems may facilitate scientific advances in health promotion. (C) 2012 Elsevier Inc. All rights reserved.
C1 [Rosenstrom, Tom; Jokela, Markus; Hintsanen, Mirka; Keltikangas-Jarvinen, Liisa] Univ Helsinki, Unit Personal Work & Hlth Psychol, IBS, Siltavuorenpenger 1 A,POB 9, FIN-00014 Helsinki, Finland.
   [Cloninger, Claude Robert] Washington Univ, Sch Med, Ctr Well Being, St Louis, MO USA.
   [Hintsanen, Mirka] Univ Helsinki, Helsinki Coll Adv Studies, FIN-00014 Helsinki, Finland.
   [Raitakari, Olli] Univ Turku, Turku Univ Hosp, Dept Clin Physiol, Turku, Finland.
   [Raitakari, Olli] Univ Turku, Res Ctr Appl & Prevent Cardiovasc Med, Turku, Finland.
   [Viikari, Jorma] Turku Univ Hosp, Dept Med, FIN-20520 Turku, Finland.
C3 University of Helsinki; Washington University (WUSTL); University of
   Helsinki; University of Turku; University of Turku; University of Turku
RP Rosenström, T (corresponding author), Univ Helsinki, Unit Personal Work & Hlth Psychol, IBS, Siltavuorenpenger 1 A,POB 9, FIN-00014 Helsinki, Finland.
EM tom.rosenstrom@helsinki.fi
RI Rosenström, Tom/AGF-2661-2022; Cloninger, Claude/F-5357-2012; Raitakari,
   Olli/AAQ-7389-2021; Jokela, Markus/A-4669-2009; Hintsanen,
   Mirka/B-6012-2008
OI Jokela, Markus/0000-0003-0117-0012; Juonala, Markus/0000-0001-9498-364X;
   Hintsanen, Mirka/0000-0003-2673-0901; Rosenstrom,
   Tom/0000-0001-8277-3776
FU Academy of Finland [124399, 124282, 121584]; Tampere and Turku
   University Hospital; Signe and Ane Gyllenberg Foundation; Emil Aaltonen
   Foundation; Niilo Helander Foundation; Finnish Foundation for
   Cardiovascular Research; Oskar Oflund Foundation; Research Foundation of
   the University of Helsinki; Academy of Finland (AKA) [124399, 124282]
   Funding Source: Academy of Finland (AKA)
FX This study was financially supported by the Academy of Finland (grant
   nos. 124399 (LKJ), 124282 and 121584), Tampere and Turku University
   Hospital Medical Funds, Signe and Ane Gyllenberg Foundation (MH), Emil
   Aaltonen Foundation (MH), Niilo Helander Foundation (MH), Finnish
   Foundation for Cardiovascular Research (MH), Oskar Oflund Foundation
   (TR), and Research Foundation of the University of Helsinki (TR). The
   sponsors had no role in preparing the manuscript. The authors gratefully
   thank Jennifer Rowland for the careful language revision.
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NR 75
TC 18
Z9 18
U1 0
U2 10
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-3999
EI 1879-1360
J9 J PSYCHOSOM RES
JI J. Psychosomat. Res.
PD MAY
PY 2012
VL 72
IS 5
BP 336
EP 343
DI 10.1016/j.jpsychores.2012.02.003
PG 8
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 925KX
UT WOS:000302761200002
PM 22469275
DA 2025-06-11
ER

PT J
AU Buler, M
   Aatsinki, SM
   Skoumal, R
   Komka, Z
   Tóth, M
   Kerkelä, R
   Georgiadi, A
   Kersten, S
   Hakkola, J
AF Buler, Marcin
   Aatsinki, Sanna-Mari
   Skoumal, Reka
   Komka, Zsolt
   Toth, Miklos
   Kerkela, Risto
   Georgiadi, Anastasia
   Kersten, Sander
   Hakkola, Jukka
TI Energy-sensing Factors Coactivator Peroxisome Proliferator-activated
   Receptor γ Coactivator 1-α (PGC-1α) and AMP-activated Protein Kinase
   Control Expression of Inflammatory Mediators in Liver INDUCTION OF
   INTERLEUKIN 1 RECEPTOR ANTAGONIST
SO JOURNAL OF BIOLOGICAL CHEMISTRY
LA English
DT Article
ID ENDOPLASMIC-RETICULUM STRESS; NECROSIS-FACTOR-ALPHA; INSULIN-RESISTANCE;
   SKELETAL-MUSCLE; HEPATIC GLUCONEOGENESIS; CALORIC RESTRICTION; METABOLIC
   SYNDROME; DIABETES-MELLITUS; NUCLEAR RECEPTORS; HUMAN OBESITY
AB Obesity and insulin resistance are associated with chronic, low grade inflammation. Moreover, regulation of energy metabolism and immunity are highly integrated. We hypothesized that energy-sensitive coactivator peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1 alpha) and AMP-activated protein kinase (AMPK) may modulate inflammatory gene expression in liver. Microarray analysis revealed that PGC-1 alpha up-regulated expression of several cytokines and cytokine receptors, including interleukin 15 receptor alpha (IL15R alpha) and, even more importantly, anti-inflammatory interleukin 1 receptor antagonist (IL1Rn). Overexpression of PGC-1 alpha and induction of PGC-1 alpha by fasting, physical exercise, glucagon, or cAMP was associated with increased IL1Rn mRNA and protein expression in hepatocytes. Knockdown of PGC-1 alpha by siRNA down-regulated cAMP-induced expression of IL1Rn in mouse hepatocytes. Furthermore, knockdown of peroxisome proliferator-activated receptor alpha (PPAR alpha) attenuated IL1Rn induction by PGC-1 alpha. Overexpression of PGC-1 alpha, at least partially through IL1Rn, suppressed interleukin 1 beta-induced expression of acute phase proteins, C-reactive protein, and haptoglobin. Fasting and exercise also induced IL15R alpha expression, whereas glucagon and cAMP resulted in reduction in IL15R alpha mRNA levels. Finally, AMPK activator metformin and adenoviral overexpression of AMPK up-regulated IL1Rn and down-regulated IL15R alpha in primary hepatocytes. We conclude that PGC-1 alpha and AMPK alter inflammatory gene expression in liver and thus integrate energy homeostasis and inflammation. Induction of IL1Rn by PGC-1 alpha and AMPK may be involved in the beneficial effects of exercise and caloric restriction and putative anti-inflammatory effects of metformin.
C1 [Buler, Marcin; Aatsinki, Sanna-Mari; Skoumal, Reka; Kerkela, Risto; Hakkola, Jukka] Univ Oulu, Dept Pharmacol & Toxicol, Inst Biomed, Oulu 90014, Finland.
   [Skoumal, Reka; Komka, Zsolt; Toth, Miklos] Semmelweis Univ, Dept Hlth Sci & Sports Med, Fac Phys Educ & Sport Sci, H-1085 Budapest, Hungary.
   [Georgiadi, Anastasia; Kersten, Sander] Wageningen Univ, Nutr Metab & Genom Grp, Div Human Nutr, NL-6703 HD Wageningen, Netherlands.
C3 University of Oulu; University of Physical Education; Semmelweis
   University; Wageningen University & Research
RP Hakkola, J (corresponding author), Univ Oulu, Dept Pharmacol & Toxicol, Inst Biomed, POB 5000,Aapistie 5B, Oulu 90014, Finland.
EM jukka.hakkola@oulu.fi
RI Buler, Marcin/J-8871-2012; Kersten, Sander/A-1116-2011
OI Hakkola, Jukka/0000-0001-5048-4363; Kersten, Sander/0000-0003-4488-7734
FU European Union; Academy of Finland [110591]; Sigrid Juselius Foundation;
   National Development Agency of Hungary [TAMOP 4.2.2-08/01/KMR-2008-004]
FX This work was supported by grants from the European Union (Marie Curie
   RTN NucSys), the Academy of Finland (Contract 110591), the Sigrid
   Juselius Foundation, and the National Development Agency of Hungary
   (Grant TAMOP 4.2.2-08/01/KMR-2008-004).
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NR 54
TC 42
Z9 59
U1 0
U2 6
PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3996 USA
EI 1083-351X
J9 J BIOL CHEM
JI J. Biol. Chem.
PD JAN 13
PY 2012
VL 287
IS 3
BP 1847
EP 1860
DI 10.1074/jbc.M111.302356
PG 14
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 879HT
UT WOS:000299321000026
PM 22117073
OA Green Published
DA 2025-06-11
ER

PT J
AU Matteucci, E
   Consani, C
   Masoni, MC
   Giampietro, O
AF Matteucci, Elena
   Consani, Cristina
   Masoni, Maria Chiara
   Giampietro, Ottavio
TI Circadian blood pressure variability in type 1 diabetes subjects and
   their nondiabetic siblings - influence of erythrocyte electron transfer
SO CARDIOVASCULAR DIABETOLOGY
LA English
DT Article
ID IMPAIRED GLUCOSE-TOLERANCE; ARTERIAL STIFFNESS INDEX; AUTONOMIC
   NEUROPATHY; GENERAL-POPULATION; INSULIN-RESISTANCE; ALBUMIN EXCRETION;
   PLASMA-GLUCOSE; PULSE PRESSURE; IDDM PATIENTS; TRANSPORT
AB Background: Normotensive non-diabetic relatives of type 1 diabetes (T1D) patients have an abnormal blood pressure response to exercise testing that is associated with indices of metabolic syndrome and increased oxidative stress. The primary aim of this study was to investigate the circadian variability of blood pressure and the ambulatory arterial stiffness index (AASI) in healthy siblings of T1D patients vs healthy control subjects who had no first-degree relative with T1D. Secondary aims of the study were to explore the influence of both cardiovascular autonomic function and erythrocyte electron transfer activity as oxidative marker on the ambulatory blood pressure profile.
   Methods: Twenty-four hour ambulatory blood pressure monitoring (ABPM) was undertaken in 25 controls, 20 T1D patients and 20 siblings. In addition to laboratory examination (including homeostasis model assessment of insulin sensitivity) and clinical testing of autonomic function, we measured the rate of oxidant-induced erythrocyte electron transfer to extracellular ferricyanide (RBC vfcy).
   Results: Systolic blood pressure (SBP) midline-estimating statistic of rhythm and pulse pressure were higher in T1D patients and correlated positively with diabetes duration and RBC vfcy; autonomic dysfunction was associated with diastolic BP ecphasia and increased AASI. Siblings had higher BMI, lower insulin sensitivity, larger SBP amplitude, and higher AASI than controls. Daytime SBP was positively, independently associated with BMI and RBC vfcy. Among non-diabetic people, there was a significant correlation between AASI and fasting plasma glucose.
   Conclusions: Siblings of T1D patients exhibited a cluster of sub-clinical metabolic abnormalities associated with consensual perturbations in BP variability. Moreover, our findings support, in a clinical setting, the proposed role of transplasma membrane electron transport systems in vascular pathobiology.
C1 [Matteucci, Elena; Consani, Cristina; Masoni, Maria Chiara; Giampietro, Ottavio] Univ Pisa, Dept Internal Med, I-56126 Pisa, Italy.
C3 University of Pisa
RP Matteucci, E (corresponding author), Univ Pisa, Dept Internal Med, Via Roma 67, I-56126 Pisa, Italy.
EM ematteuc@int.med.unipi.it
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NR 40
TC 10
Z9 11
U1 0
U2 4
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1475-2840
J9 CARDIOVASC DIABETOL
JI Cardiovasc. Diabetol.
PD OCT 5
PY 2010
VL 9
AR 61
DI 10.1186/1475-2840-9-61
PG 9
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism
GA 668WP
UT WOS:000283305000001
PM 20920366
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Kelishadi, R
   Hashemipour, M
   Sarrafzadegan, N
   Mohammadifard, N
   Alikhasy, H
   Beizaei, M
   Sajjadi, F
   Poursafa, P
   Amin, Z
   Ghatreh-Samani, S
   Khavarian, N
   Siadat, ZD
AF Kelishadi, Roya
   Hashemipour, Mahin
   Sarrafzadegan, Nizal
   Mohammadifard, Noushin
   Alikhasy, Hasan
   Beizaei, Maryam
   Sajjadi, Firouzeh
   Poursafa, Parinaz
   Amin, Zahra
   Ghatreh-Samani, Shohreh
   Khavarian, Noushin
   Siadat, Zahra Dana
TI Effects of a lifestyle modification trial among phenotypically obese
   metabolically normal and phenotypically obese metabolically abnormal
   adolescents in comparison with phenotypically normal metabolically obese
   adolescents
SO MATERNAL AND CHILD NUTRITION
LA English
DT Article
DE cardio-metabolic disorders; obesity; adolescents; lifestyle modification
ID C-REACTIVE PROTEIN; CARDIOVASCULAR RISK-FACTORS; INTIMA-MEDIA THICKNESS;
   INSULIN-RESISTANCE; PHYSICAL-ACTIVITY; ANTHROPOMETRIC INDEXES;
   INFLAMMATORY MARKERS; OXIDATIVE STRESS; IRANIAN CHILDREN; REFERENCE
   CURVES
AB This study aimed to assess the effects of a 2-month lifestyle modification trial on cardio-metabolic abnormalities and C-reactive protein (CRP) among obese adolescents with metabolic syndrome [phenotypically obese metabolically abnormal (POMA)] and obese adolescents without a cardio-metabolic disorder [phenotypically obese metabolically normal (POMN)], as well as in normal-weight adolescents with at least one cardio-metabolic disorder [phenotypically normal metabolically obese (PNMO)].
   The study comprised 360 adolescents assigned in three groups of equal number of POMN, POMA and PNMO. They were enrolled in a trial consisting of aerobic activity classes, diet and behaviour modification, and were recalled after 6 months.
   Overall, 94.7% of participants completed the 2-month trial, and 87.3% of them returned after 6 months. The mean CRP was not significantly different between the POMA and PNMO groups, but was higher than in the POMN group. After the trial, body mass index (BMI) and waist circumference (WC) decreased in obese participants, and the mean body fat mass decreased in all groups. At 2 months, the mean total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG) and CRP decreased in the POMA and PNMO groups. After 2 and 6 months, the decrease in mean TC, LDL-C, TG, CRP and systolic blood pressure was greater in the POMA than in the POMN group. The magnitude of decrease in CRP correlated with that of BMI, WC, fat mass, TG, TC and LDL-C.
   Lifestyle modification programmes for primordial/primary prevention of chronic diseases would be beneficial at the population level and should not be limited to obese children.
C1 [Kelishadi, Roya; Beizaei, Maryam; Ghatreh-Samani, Shohreh; Khavarian, Noushin] Isfahan Univ Med Sci, Pediat Prevent Cardiol Dept, Isfahan Cardiovasc Res Ctr, Esfahan 8164743685, Iran.
   [Hashemipour, Mahin] Isfahan Univ Med Sci, Pediat Endocrinol Dept, Isfahan Endocrine & Metab Res Ctr, Esfahan 8164743685, Iran.
   [Sarrafzadegan, Nizal] Isfahan Univ Med Sci, Dept Cardiol, Isfahan Cardiovasc Res Ctr, Esfahan 8164743685, Iran.
   [Mohammadifard, Noushin; Alikhasy, Hasan; Sajjadi, Firouzeh] Isfahan Univ Med Sci, Dept Nutr, Isfahan Cardiovasc Res Ctr, Esfahan 8164743685, Iran.
   [Poursafa, Parinaz] Isfahan Univ Technol, Esfahan, Iran.
   [Amin, Zahra] Isfahan Prov Phys Act & Sport Org, Res & Training Unit, Esfahan, Iran.
   [Siadat, Zahra Dana] Isfahan Univ Med Sci, Res Unit, Isfahan Cardiovasc Res Ctr, Esfahan 8164743685, Iran.
C3 Isfahan University of Medical Sciences; Isfahan University of Medical
   Sciences; Isfahan University of Medical Sciences; Isfahan University of
   Medical Sciences; Isfahan University of Technology; Isfahan University
   of Medical Sciences
RP Kelishadi, R (corresponding author), Isfahan Univ Med Sci, Pediat Prevent Cardiol Dept, Isfahan Cardiovasc Res Ctr, POB 81465-1148,Khorram St, Esfahan 8164743685, Iran.
EM kroya@aap.net
RI siadat, zahra/W-1895-2017; Mohammadifard, Noushin/M-2244-2018;
   Sarrafzadegan, Nizal/V-5826-2017; Kelishadi, Roya/E-6154-2012; Mehrkash,
   Mehryar/D-5317-2018; Poursafa, Parinaz/U-2924-2017
OI Sarrafzadegan, Nizal/0000-0002-8352-0540; siadat, zahra
   dana/0000-0002-3048-2325; Kelishadi, Roya/0000-0001-7455-1495; Mehrkash,
   Mehryar/0000-0001-6418-5743; Poursafa, Parinaz/0000-0002-8067-4122
FU Vice Chancellery for Research, Isfahan University of Medical Sciences,
   Isfahan, Iran [185177]
FX The study was funded by grant no. 185177 from the Vice Chancellery for
   Research, Isfahan University of Medical Sciences, Isfahan, Iran.
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NR 49
TC 21
Z9 22
U1 0
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1740-8695
EI 1740-8709
J9 MATERN CHILD NUTR
JI Matern. Child Nutr.
PD JUL
PY 2010
VL 6
IS 3
BP 275
EP 286
DI 10.1111/j.1740-8709.2009.00207.x
PG 12
WC Nutrition & Dietetics; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics; Pediatrics
GA 612QJ
UT WOS:000278915900007
PM 20929499
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Samane, S
   Christon, R
   Dombrowski, L
   Turcotte, S
   Charrouf, Z
   Lavigne, C
   Levy, E
   Bachelard, H
   Amarouch, H
   Marette, A
   Haddad, PS
AF Samane, Samira
   Christon, Raymond
   Dombrowski, Luce
   Turcotte, Stephane
   Charrouf, Zoubida
   Lavigne, Charles
   Levy, Emile
   Bachelard, Helene
   Amarouch, Hamid
   Marette, Andre
   Haddad, Pierre Selim
TI Fish oil and argan oil intake differently modulate insulin resistance
   and glucose intolerance in a rat model of dietary-induced obesity
SO METABOLISM-CLINICAL AND EXPERIMENTAL
LA English
DT Article
ID POLYUNSATURATED FATTY-ACIDS; SPONTANEOUSLY HYPERTENSIVE-RATS; VASCULAR
   ENDOTHELIAL-CELLS; INDUCED DIABETES-MELLITUS; SKELETAL-MUSCLE;
   CARDIOVASCULAR-DISEASE; OXIDATIVE STRESS; GLUT4 TRANSLOCATION; METABOLIC
   SYNDROME; RISK-FACTORS
AB We investigated the potential metabolic benefits of fish oil (FO) or vegetable argan oil (AO) intake in a dietary model of obesity-linked insulin resistance. Rats were fed a standard chow diet (controls), a high-fat/high-sucrose (HFHS) diet, or an HFHS diet in which 6% of the fat was replaced by either FO or AO feeding, respectively. The HFHS diet increased adipose tissue weight and insulin resistance as revealed by increased fasting glucose and exaggerated glycemic and insulin responses to a glucose tolerance test (intraperitoneal glucose tolerance test). Fish oil feeding prevented fat accretion, reduced fasting glycemia, and normalized glycemic or insulin responses to intraperitoneal glucose tolerance test as compared with HFHS diet. Unlike FO consumption, AO intake failed to prevent obesity, yet restored fasting glycerma back to chow-fed control values. Insulin-induced phosphorylation of Akt and Erk in adipose tissues, skeletal muscles, and liver was greatly attenuated in HFHS rats as compared with chow-fed controls. High-fat/high-sucrose diet-induced insulin resistance was also confirmed in isolated hepatocytes. Fish oil intake prevented insulin resistance by improving or fully restoring insulin signaling responses in all tissues and isolated hepatocytes. Argan oil intake also improved insulin-dependent phosphorylations of Akt and Erk; and in adipose tissue, these responses were increased even beyond values observed in chow-fed controls. Taken together, these results strongly support the beneficial action of FO on diet-induced insulin resistance and glucose intolerance, an effect likely explained by the ability of FO to prevent HFHS-induced adiposity. Our data also show for the first time that AO can improve some of the metabolic and insulin signaling abnormalities associated with HFHS feeding. (C) 2009 Elsevier Inc. All rights reserved.
C1 [Samane, Samira; Christon, Raymond; Dombrowski, Luce; Turcotte, Stephane; Lavigne, Charles; Levy, Emile; Bachelard, Helene; Marette, Andre; Haddad, Pierre Selim] Univ Laval, Inst Nutraceut & Aliments Fonct, Quebec City, PQ G1K 7P4, Canada.
   [Samane, Samira; Haddad, Pierre Selim] Univ Montreal, Dept Pharmacol, Montreal, PQ H3C 3J7, Canada.
   [Samane, Samira; Amarouch, Hamid] Hassan II Univ, Dept Biol, Casablanca, Morocco.
   [Christon, Raymond] Univ Paris 11, INRA Physiol, UMR 1154, F-92290 Chatenay Malabry, France.
   [Dombrowski, Luce; Turcotte, Stephane; Lavigne, Charles; Marette, Andre] Laval Univ Hosp, Res Ctr, Dept Anat & Physiol, Quebec City, PQ G1V 4G2, Canada.
   [Dombrowski, Luce; Turcotte, Stephane; Lavigne, Charles; Bachelard, Helene; Marette, Andre] Laval Univ Hosp, Res Ctr, Lipid Res Unit, Quebec City, PQ G1V 4G2, Canada.
   [Charrouf, Zoubida] Mohammed V Univ, Dept Chem, Rabat, Morocco.
   [Levy, Emile] St Justine Childrens Hosp, Res Ctr, Montreal, PQ, Canada.
   [Bachelard, Helene] Laval Univ Hosp, Res Ctr, Dept Med, Quebec City, PQ G1V 4G2, Canada.
C3 Laval University; Universite de Montreal; Hassan II University of
   Casablanca; Universite Paris Saclay; INRAE; Laval University; Laval
   University Hospital; Laval University; Laval University Hospital;
   Mohammed V University in Rabat; Laval University; Laval University
   Hospital
RP Marette, A (corresponding author), Univ Laval, Inst Nutraceut & Aliments Fonct, Quebec City, PQ G1K 7P4, Canada.
EM andre.marette@crchul.ulaval.ca; pierre.haddad@umontreal.ca
RI Marette, Andre/E-9342-2013
OI Turcotte, Stephane/0000-0001-6031-4958; Marette,
   Andre/0000-0003-3950-5973
FU Canadian Institutes of Health Research; Canadian Diabetes Association;
   Advanced Food and Materials Network; Nutriceutical and Functional Foods
   Institute of Laval University
FX These studies were supported by grants from the Canadian Institutes of
   Health Research, the Canadian Diabetes Association, the Advanced Food
   and Materials Network, and the Nutriceutical and Functional Foods
   Institute of Laval University (a strategic group funded by the Quebec
   Research Fund for Nature and Technology).
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NR 60
TC 67
Z9 71
U1 0
U2 15
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0026-0495
EI 1532-8600
J9 METABOLISM
JI Metab.-Clin. Exp.
PD JUL
PY 2009
VL 58
IS 7
BP 909
EP 919
DI 10.1016/j.metabol.2009.02.013
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 460LZ
UT WOS:000267190500003
PM 19394055
DA 2025-06-11
ER

PT J
AU Ntemiri, A
   Ghosh, TS
   Gheller, ME
   Tran, TTT
   Blum, JE
   Pellanda, P
   Vlckova, K
   Neto, MC
   Howell, A
   Thalacker-Mercer, A
   O'Toole, PW
AF Ntemiri, Alexandra
   Ghosh, Tarini S.
   Gheller, Molly E.
   Tran, Tam T. T.
   Blum, Jamie E.
   Pellanda, Paola
   Vlckova, Klara
   Neto, Marta C.
   Howell, Amy
   Thalacker-Mercer, Anna
   O'Toole, Paul W.
TI Whole Blueberry and Isolated Polyphenol-Rich Fractions Modulate Specific
   Gut Microbes in an In Vitro Colon Model and in a Pilot Study in Human
   Consumers
SO NUTRIENTS
LA English
DT Article
DE polyphenols; blueberries; gut microbiota; in vitro; human study;
   oxidative stress
ID DIETARY FLAVONOID INTAKE; INTESTINAL MICROBIOTA; INSULIN-RESISTANCE;
   METABOLIC SYNDROME; RUMINOCOCCUS-BROMII; HUMAN HEALTH; CRANBERRY;
   ANTHOCYANINS; INFLAMMATION; CONSUMPTION
AB Blueberry (BB) consumption is linked to improved health. The bioconversion of the polyphenolic content of BB by fermentative bacteria in the large intestine may be a necessary step for the health benefits attributed to BB consumption. The identification of specific gut microbiota taxa that respond to BB consumption and that mediate the bioconversion of consumed polyphenolic compounds into bioactive forms is required to improve our understanding of how polyphenols impact human health. We tested the ability of polyphenol-rich fractions purified from whole BB-namely, anthocyanins/flavonol glycosides (ANTH/FLAV), proanthocyanidins (PACs), the sugar/acid fraction (S/A), and total polyphenols (TPP)-to modulate the fecal microbiota composition of healthy adults in anin vitrocolon system. In a parallel pilot study, we tested the effect of consuming 38 g of freeze-dried BB powder per day for 6 weeks on the fecal microbiota of 17 women in two age groups (i.e., young and older). The BB ingredients had a distinct effect on the fecal microbiota composition in the artificial colon model. The ANTH/FLAV and PAC fractions were more effective in promoting microbiome alpha diversity compared to S/A and TPP, and these effects were attributed to differentially responsive taxa. Dietary enrichment with BB resulted in a moderate increase in the diversity of the microbiota of the older subjects but not in younger subjects, and certain health-relevant taxa were significantly associated with BB consumption. Alterations in the abundance of some gut bacteria correlated not only with BB consumption but also with increased antioxidant activity in blood. Collectively, these pilot data support the notion that BB consumption is associated with gut microbiota changes and health benefits.
C1 [Ntemiri, Alexandra; Ghosh, Tarini S.; Tran, Tam T. T.; Pellanda, Paola; Vlckova, Klara; Neto, Marta C.; O'Toole, Paul W.] Univ Coll Cork, Sch Microbiol, Cork T12 K8AF, Ireland.
   [Ntemiri, Alexandra; Ghosh, Tarini S.; Tran, Tam T. T.; Pellanda, Paola; Vlckova, Klara; Neto, Marta C.; O'Toole, Paul W.] Univ Coll Cork, APC Microbiome Ireland, Cork T12 K8AF, Ireland.
   [Howell, Amy] Rutgers State Univ, Marucci Ctr Blueberry Cranberry Res, Chatsworth, NJ 08019 USA.
   [Gheller, Molly E.; Blum, Jamie E.; Thalacker-Mercer, Anna] Cornell Univ, Div Nutr Sci, Ithaca, NY 14853 USA.
   [Thalacker-Mercer, Anna] Univ Alabama Birmingham, Dept Cell Dev & Integrat Biol, Birmingham, AL 35294 USA.
C3 University College Cork; University College Cork; Rutgers University
   System; Rutgers University New Brunswick; Cornell University; University
   of Alabama System; University of Alabama Birmingham
RP O'Toole, PW (corresponding author), Univ Coll Cork, Sch Microbiol, Cork T12 K8AF, Ireland.; O'Toole, PW (corresponding author), Univ Coll Cork, APC Microbiome Ireland, Cork T12 K8AF, Ireland.
EM alexandra.ntemiri@ucc.ie; tarini.ghosh@ucc.ie; meg369@cornell.edu;
   tam.tran@ucc.ie; jeb462@cornell.edu; paola.pellanda@ucc.ie;
   klara.vlckova@ucc.ie; marta.neto@ucc.ie; ahowell@njaes.rutgers.edu;
   aet74@cornell.edu; pwotoole@ucc.ie
RI Tran, Tam/JJF-1520-2023; Ghosh, Tarini/AAW-5456-2020; O'Toole,
   Paul/G-1593-2012; Ntemiri, Alexandra/AAY-6236-2020
OI Ghosh, Tarini/0000-0001-9570-0365; Costa Neto,
   Marta/0000-0002-4699-7657; Vlckova, Klara/0000-0002-8774-9983; Ntemiri,
   Alexandra/0000-0002-8742-0627; Blum, Jamie/0000-0002-2168-5390; Tran,
   Tam/0000-0002-7691-2888; Howell, Amy/0000-0002-8069-7017
FU Government of Ireland National Development Plan by way of a Department
   of Agriculture, Food, and the Marine (DAFM) under a Food Institutional
   Research Measure (FIRM) award [14F828]; Science Foundation Ireland
   [12/RC/2273_P2]; National Science Foundation Graduate Research
   Fellowship Program [DGE-1650441]; U.S. Highbush Blueberry Council;
   Science Foundation Ireland (SFI) [12/RC/2273_P2] Funding Source: Science
   Foundation Ireland (SFI)
FX This research was funded by the following: Work in PWOT's laboratory is
   supported by the Government of Ireland National Development Plan by way
   of a Department of Agriculture, Food, and the Marine (DAFM) under a Food
   Institutional Research Measure (FIRM) award (14F828), and by a centre
   award to APC Microbiome Ireland (12/RC/2273_P2) from Science Foundation
   Ireland. Work in ATM's laboratory is supported by the National Science
   Foundation Graduate Research Fellowship Program under Grant No.
   DGE-1650441 (to JEB). This research was also funded by a grant from the
   U.S. Highbush Blueberry Council to ATM.
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NR 105
TC 42
Z9 44
U1 1
U2 52
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD SEP
PY 2020
VL 12
IS 9
AR 2800
DI 10.3390/nu12092800
PG 21
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA OE7FL
UT WOS:000580692000001
PM 32932733
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Bukosza, EN
   Kaucsár, T
   Godó, M
   Lajtár, E
   Tod, P
   Koncsos, G
   Varga, ZV
   Baranyai, T
   Tu, NM
   Schachner, H
   Soti, C
   Ferdinandy, P
   Giricz, Z
   Szénási, G
   Hamar, P
AF Bukosza, Eva Nora
   Kaucsar, Tamas
   Godo, Maria
   Lajtar, Eniko
   Tod, Pal
   Koncsos, Gabor
   Varga, Zoltan V.
   Baranyai, Tamas
   Nguyen Minh Tu
   Schachner, Helga
   Soti, Csaba
   Ferdinandy, Peter
   Giricz, Zoltan
   Szenasi, Gabor
   Hamar, Peter
TI Glomerular Collagen Deposition and Lipocalin-2 Expression Are Early
   Signs of Renal Injury in Prediabetic Obese Rats
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE obesity; renal injury; lipocalin-2; collagen type IV; inflammation
ID DISEASE PROGRESSION; LIPID-ACCUMULATION; METABOLIC SYNDROME;
   DIABETES-MELLITUS; LEPTIN; DYSFUNCTION; INHIBITION; CELLS;
   HYPERFILTRATION; COMORBIDITIES
AB Feeding rats with high-fat diet (HFD) with a single streptozotocin (STZ) injection induced obesity, slightly elevated fasting blood glucose and impaired glucose and insulin tolerance, and caused cardiac hypertrophy and mild diastolic dysfunction as published before by Koncsos et al. in 2016. Here we aimed to explore the renal consequences in the same groups of rats. Male Long-Evans rats were fed normal chow (CON; n = 9) or HFD containing 40% lard and were administered STZ at 20 mg/kg (i.p.) at week four (prediabetic rats, PRED, n = 9). At week 21 blood and urine samples were taken and kidney and liver samples were collected for histology, immunohistochemistry and for analysis of gene expression. HFD and STZ increased body weight and visceral adiposity and plasma leptin concentration. Despite hyperleptinemia, plasma C-reactive protein concentration decreased in PRED rats. Immunohistochemistry revealed elevated collagen IV protein expression in the glomeruli, and Lcn2 mRNA expression increased, while Il-1 beta mRNA expression decreased in both the renal cortex and medulla in PRED vs. CON rats. Kidney histology, urinary protein excretion, plasma creatinine, glomerular Feret diameter, desmin protein expression, and cortical and medullary mRNA expression of TGF-beta 1, Nrf2, and PPAR gamma were similar in CON and PRED rats. Reduced AMPK alpha phosphorylation of the autophagy regulator Akt was the first sign of liver damage, while plasma lipid and liver enzyme concentrations were similar. In conclusion, glomerular collagen deposition and increased lipocalin-2 expression were the early signs of kidney injury, while most biomarkers of inflammation, oxidative stress and fibrosis were negative in the kidneys of obese, prediabetic rats with mild heart and liver injury.
C1 [Bukosza, Eva Nora; Kaucsar, Tamas; Godo, Maria; Lajtar, Eniko; Tod, Pal; Szenasi, Gabor; Hamar, Peter] Semmelweis Univ, Inst Pathophysiol, H-1089 Budapest, Hungary.
   [Bukosza, Eva Nora] Med Univ Vienna, Dept Pathol, A-1090 Vienna, Austria.
   [Koncsos, Gabor; Varga, Zoltan V.; Baranyai, Tamas; Ferdinandy, Peter; Giricz, Zoltan] Semmelweis Univ, Dept Pharmacol & Pharmacotherapy, H-1089 Budapest, Hungary.
   [Nguyen Minh Tu; Schachner, Helga; Soti, Csaba] Semmelweis Univ, Dept Med Chem Mol Biol & Pathobiochem, H-1089 Budapest, Hungary.
   [Ferdinandy, Peter] Pharmahungary Grp, H-1089 Budapest, Hungary.
   [Hamar, Peter] Semmelweis Univ, Inst Expt Clin Res, H-1089 Budapest, Hungary.
   [Hamar, Peter] Pecs Univ, Inst Translat Med, H-7624 Pecs, Hungary.
C3 Semmelweis University; Medical University of Vienna; Semmelweis
   University; Semmelweis University; Pharmahungary Group; Semmelweis
   University; University of Pecs
RP Hamar, P (corresponding author), Semmelweis Univ, Inst Pathophysiol, H-1089 Budapest, Hungary.; Hamar, P (corresponding author), Semmelweis Univ, Inst Expt Clin Res, H-1089 Budapest, Hungary.; Hamar, P (corresponding author), Pecs Univ, Inst Translat Med, H-7624 Pecs, Hungary.
EM hamar.peter@med.semmelweis-univ.hu
RI Giricz, Zoltán/B-6990-2008; Kaucsár, Tamás/H-4904-2016; Tod,
   Pál/H-9607-2018; Sőti, Csaba/JQP-1191-2023; Szenasi, Gabor/K-3136-2017;
   Ferdinandy, Péter/H-9181-2019; Varga, Zoltan/J-9264-2017
OI Varga, Zoltan/0000-0002-2758-0784
FU Hungarian Research Fund [OTKA SNN-114619, ANN-110810, OTKA K116525, OTKA
   109737]; National Research, Development and Innovation Fund of Hungary
   [NVKP_ 16-1-2016-0042, NVKP-16-12016-0017]; Economic Development and
   Innovation Operative Program [GINOP 2.3.2-15-2016-00048]; Kispal Gyula
   startup grant [300021]; Semmelweis University
   [EFOP-3.6.3-VEKOP-16-201700009]; Hungarian Academy of Sciences; Premium
   Postdoctoral Fellowship Program of the Hungarian Academy of Sciences
FX Support was provided by the Hungarian Research Fund: OTKA SNN-114619
   (HP), ANN-110810 (HP), OTKA K116525 (CS), OTKA 109737 (PF, ZG), by the
   National Research, Development and Innovation Fund of Hungary: NVKP_
   16-1-2016-0042 (HP), NVKP-16-12016-0017 (PF, ZG), by the Economic
   Development and Innovation Operative Program Grant: GINOP
   2.3.2-15-2016-00048 (HP). Peter Hamar is a recipient of the Kispal Gyula
   startup grant (300021) of the University of Pecs. Gabor Koncsos was
   supported by the Semmelweis University (EFOP-3.6.3-VEKOP-16-201700009).
   Zoltan Giricz held a 'Janos Bolyai Fellowship' from the Hungarian
   Academy of Sciences (awarded in 2013 and 2017). Zoltan V. Varga was
   supported by the Premium Postdoctoral Fellowship Program of the
   Hungarian Academy of Sciences.
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NR 49
TC 9
Z9 9
U1 0
U2 0
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD SEP 1
PY 2019
VL 20
IS 17
AR 4266
DI 10.3390/ijms20174266
PG 17
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA IZ2AF
UT WOS:000486888400198
PM 31480394
OA Green Accepted, gold, Green Published
DA 2025-06-11
ER

PT J
AU Cheng, G
   Mahmoudi, H
   Chokshi, B
   Fernandez, M
   Kazemi, V
   Lamaa, N
AF Cheng, Gang
   Mahmoudi, Hilda
   Chokshi, Binna
   Fernandez, Marlena
   Kazemi, Vahid
   Lamaa, Nader
TI The relationship between fasting blood glucose variability and coronary
   artery collateral formation in type 2 diabetes patients with coronary
   artery disease
SO CORONARY ARTERY DISEASE
LA English
DT Article
DE angiogenesis; coronary artery disease; coronary collateral; diabetes
   mellitus; glycemic variability; hyperglycemia
ID ENDOTHELIAL PROGENITOR CELLS; GLYCEMIC VARIABILITY; HBA(1C) VARIABILITY;
   METABOLIC SYNDROME; CARDIOVASCULAR-DISEASE; HBA1C VARIABILITY; OXIDATIVE
   STRESS; VESSEL FORMATION; A1C VARIABILITY; PLASMA-GLUCOSE
AB Background Coronary collaterals are an alternative source of blood supply to ischemic myocardium. Well-developed coronary collateral arteries in patients with coronary artery disease (CAD) limit the size of acute myocardial infarction and improves survival. The aim of this study was to investigate the relationship between glycemic variability and coronary collateral formation in patients with type 2 diabetes mellitus and CAD.
   Methods Consecutive patients undergoing percutaneous coronary intervention or coronary artery bypass grafting procedures were studied. Multivariate logistic regression models were used to examine the association between coronary artery collateral formation graded by Rentrope classification and glycemic variability, measured by coefficient variation of fasting blood glucose.
   Results In our study, we retrospectively enrolled 300 patients, of whom 239 were diabetic (age: 70.1 +/- 11.9, 56% men) and 61 were nondiabetic (age: 71.5 +/- 11.5, 72% men). Diabetic patients were further stratified as follows: those with poor coronary collateral artery development (n = 171, age: 69.7 +/- 12.4, 55% men) and those with good coronary collateral artery development (n = 68, age 71.1 +/- 10.8, 59% men) according to the Rentrope classification. Our findings did not show association between glycemic variability and coronary collateral vessels development after controlling for potential confounders (odds ratio: 2.51; 95% confidence interval: 0.57-11.03; P = 0.22). The culprit lesion (>= 75% stenosis) in the left anterior descending artery and the right coronary artery was more frequent in the good collateral group compared with the poor collateral group (66 vs. 50%, P = 0.02; 63 vs. 45%, P = 0.01 respectively).
   Conclusion Glycemic variability is not associated with coronary collateral artery formation in patients with type 2 diabetes mellitus and CAD. (C) 2017 Wolters Kluwer Health, Inc. All rights reserved.
C1 [Cheng, Gang; Mahmoudi, Hilda; Chokshi, Binna; Fernandez, Marlena; Kazemi, Vahid; Lamaa, Nader] Aventura Hosp & Med Ctr, Internal Med Dept, Aventura, FL USA.
   [Mahmoudi, Hilda] Nova Southeastern Univ, Coll Osteopath Med, Ft Lauderdale Daive, FL USA.
C3 Nova Southeastern University
RP Mahmoudi, H (corresponding author), Aventura Hosp & Med Ctr, 20900 Biscayne Blvd, Aventura, FL 33180 USA.
EM hilda.mahmoudi@hcahealthcare.com
RI mahmoudi, hilda/H-4666-2011
OI Mahmoudi, Hilda/0000-0003-0304-0254
CR [Anonymous], 2015, MEDICINE
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NR 50
TC 2
Z9 2
U1 1
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0954-6928
EI 1473-5830
J9 CORONARY ARTERY DIS
JI Coronary Artery Dis.
PD SEP
PY 2017
VL 28
IS 6
BP 486
EP 491
DI 10.1097/MCA.0000000000000520
PG 6
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA FC7WW
UT WOS:000407054100008
PM 28644211
DA 2025-06-11
ER

PT J
AU Ping, F
   Li, ZY
   Lv, K
   Zhou, MC
   Dong, YX
   Sun, Q
   Li, YX
AF Ping, Fan
   Li, Zeng-yi
   Lv, Ke
   Zhou, Mei-cen
   Dong, Ya-xiu
   Sun, Qi
   Li, Yu-xiu
TI Deoxyribonucleic acid telomere length shortening can predict the
   incidence of non-alcoholic fatty liver disease in patients with type 2
   diabetes mellitus
SO JOURNAL OF DIABETES INVESTIGATION
LA English
DT Article
DE Non-alcoholic fatty liver disease; Telomere shortening; Type 2 diabetes
   mellitus
ID METABOLIC SYNDROME; INSULIN SENSITIVITY; GLUCOSE-TOLERANCE;
   STEATOHEPATITIS; DYSFUNCTION; PROGRESSION; MARKERS; INDEXES; STRESS;
   NAFLD
AB Aims/Introduction: To investigate the effect of telomere shortening and other predictive factors of non-alcoholic fatty liver disease (NAFLD) in type 2 diabetes mellitus patients in a 6-year prospective cohort study.
   Materials and Methods: A total of 70 type 2 diabetes mellitus (mean age 57.8 +/- 6.7 years) patients without NAFLD were included in the study, and 64 of them were successfully followed up 6 years later, excluding four cases with significant alcohol consumption. NAFLD was diagnosed by the hepatorenal ratio obtained by a quantitative ultrasound method using NIH image analysis software. The 39 individuals that developed NAFLD were allocated to group A, and the 21 individuals that did not develop NAFLD were allocated to group B. Fluorescent real-time quantitative polymerase chain reaction was used to measure telomere length.
   Results: There was no significant difference between the two groups in baseline telomere length; however, at the end of the 6th year, telomere length had become shorter in group A compared with group B. There were significant differences between these two groups in baseline body mass index, waistline, systolic blood pressure, glycated hemoglobin and fasting C-peptide level. In addition, the estimated indices of baseline insulin resistance increased in group A. Fasting insulin level, body mass index, systolic blood pressure at baseline and the shortening of telomere length were independent risk factors of NAFLD in type 2 diabetes mellitus patients.
   Conclusions: Telomere length became shorter in type 2 diabetes mellitus patients who developed NAFLD over the course of 6 years. Type 2 diabetes mellitus patients who developed NAFLD had more serious insulin resistance compared with those who did not develop NAFLD a long time ago.
C1 [Ping, Fan; Zhou, Mei-cen; Dong, Ya-xiu; Sun, Qi; Li, Yu-xiu] Chinese Acad Med Sci, Peking Union Med Coll Hosp, Peking Union Med Coll, Dept Endocrinol,Key Lab Endocrinol,Minist Hlth, Beijing, Peoples R China.
   [Li, Zeng-yi] Nanyang City Ctr Hosp, Nanyang, Henan Province, Peoples R China.
   [Lv, Ke] Chinese Acad Med Sci, Dept Ultrasound, Peking Union Med Coll Hosp, Peking Union Med Coll, Beijing, Peoples R China.
C3 Chinese Academy of Medical Sciences - Peking Union Medical College;
   Peking Union Medical College Hospital; Peking Union Medical College;
   Chinese Academy of Medical Sciences - Peking Union Medical College;
   Peking Union Medical College Hospital; Peking Union Medical College
RP Li, YX (corresponding author), Chinese Acad Med Sci, Peking Union Med Coll Hosp, Peking Union Med Coll, Dept Endocrinol,Key Lab Endocrinol,Minist Hlth, Beijing, Peoples R China.
EM pumch_endodia-betes@126.com
RI Li, Yuxiu/AAE-1202-2022
FU National Natural Science Foundation of China [81270878]; National Key
   Program of Clinical Science of China
FX We sincerely appreciate all participants in this study, and all medical
   staff for their invaluable assistance in providing and collecting
   specimen. This project was supported by the National Natural Science
   Foundation of China (grant no. 81270878) and National Key Program of
   Clinical Science of China.
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NR 24
TC 28
Z9 29
U1 0
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2040-1124
J9 J DIABETES INVEST
JI J. Diabetes Investig.
PD MAR
PY 2017
VL 8
IS 2
BP 174
EP 180
DI 10.1111/jdi.12555
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA EQ4PB
UT WOS:000398059100008
PM 27451965
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Shen, ZW
   Xing, J
   Wang, QL
   Faheem, A
   Ji, X
   Li, J
   Bian, WW
   Jiang, Z
   Li, XJ
   Xue, FZ
   Liu, J
AF Shen, Zhen-Wei
   Xing, Jie
   Wang, Qing-Lian
   Faheem, Ali
   Ji, Xiang
   Li, Jie
   Bian, Wei-Wei
   Jiang, Zheng
   Li, Xiu-Jun
   Xue, Fu-Zhong
   Liu, Jing
TI Association between serum γ-glutamyltransferase and chronic kidney
   disease in urban Han Chinese: a prospective cohort study
SO INTERNATIONAL UROLOGY AND NEPHROLOGY
LA English
DT Article
DE Chronic kidney disease (CKD); GGT; Cohort study; Cox
ID ENDOTHELIAL FUNCTION; METABOLIC SYNDROME; OXIDATIVE STRESS; RISK;
   FIBROSIS; MARKER; GLUTAMYLTRANSFERASE; HYPERTENSION; METAANALYSIS;
   PREVALENCE
AB Limited numbers of literatures have focused on the association between gamma-glutamyltransferase (GGT) and chronic kidney disease (CKD), and their results were controversial. Therefore, in this study, we set up a large-scale cohort of Chinese population to discover and verify the association between serum GGT and CKD.
   Our cohort study was based on 21,818 patients who visited Health Management Center of Shandong Provincial Hospital, China, to receive routine health check-up during the period of 2005-2010, and we used multivariate Cox regression model to clarify whether elevated serum GGT increased the risk of CKD or not.
   During the follow-up of 57,891 person-years, 1456 patients developed CKD, giving rise to an incidence density of 25.15 per 1000 person-years (1456/57,891 person-years). After adjusting gender, age, baseline serum creatinine (SCr), body mass index (BMI), serum albumin (ALB), alanine aminotransferase (ALT), hemoglobin, white blood cell count (WBC), triglyceride (TG), total cholesterol (TC), hypertension, cardiovascular disease (CVD), diabetes, smoking and drinking status, the risk for CKD increased with the elevated serum GGT quartiles. The hazard ratio (HR) for CKD was 1.326 (95 % confidence interval (CI), 1.073-1.639) when the top quartile of serum GGT was compared with the bottom one, and the HR of log-transformed serum GGT for CKD was 1.658 (95 % CI, 1.294-2.125). The results were consistent in males but different in females when gender was stratified.
   The result reveals that there is a positive relationship between increasing serum GGT levels and the incidence of CKD which suggests that elevated GGT level could be a potential indicator for risk of CKD.
C1 [Shen, Zhen-Wei; Li, Jie; Bian, Wei-Wei; Jiang, Zheng; Li, Xiu-Jun; Xue, Fu-Zhong; Liu, Jing] Shandong Univ, Sch Publ Hlth, Dept Biostat, 44 Wenhuaxi Rd, Jinan 250012, Shandong, Peoples R China.
   [Xing, Jie] Shandong Univ, Dept Nephrol, Qianfoshan Hosp, 16766 Jingshi Rd, Jinan 250014, Shandong, Peoples R China.
   [Wang, Qing-Lian] Shandong Univ, Dept Nephrol, Shandong Prov Hosp, 324 Jingwu Rd, Jinan 250021, Shandong, Peoples R China.
   [Faheem, Ali] Shandong Univ, Dept Hepatobiliary & Liver Transplantat, Shandong Prov Hosp, 324 Jingwu Rd, Jinan 250021, Shandong, Peoples R China.
   [Ji, Xiang] Shandong Univ, Dept Geriatr, Qilu Hosp, 107 Wenhuaxi Rd, Jinan 250012, Shandong, Peoples R China.
C3 Shandong University; Shandong University; Shandong First Medical
   University & Shandong Academy of Medical Sciences; Shandong First
   Medical University & Shandong Academy of Medical Sciences; Shandong
   University; Shandong University; Shandong First Medical University &
   Shandong Academy of Medical Sciences; Shandong University
RP Liu, J (corresponding author), Shandong Univ, Sch Publ Hlth, Dept Biostat, 44 Wenhuaxi Rd, Jinan 250012, Shandong, Peoples R China.
EM liujing@sdu.edu.cn
RI Xue, Fuzhong/AAG-4808-2020; xiangfen, Ji/KEH-8115-2024; wang,
   qinglian/JOZ-5258-2023
OI FAHEEM, ALI/0009-0009-4956-8397
FU Shandong Province outstanding young scientist research award fund
   [BS2014YY021]
FX This work was funded by Shandong Province outstanding young scientist
   research award fund (BS2014YY021).
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NR 44
TC 29
Z9 31
U1 0
U2 11
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0301-1623
EI 1573-2584
J9 INT UROL NEPHROL
JI Int. Urol. Nephrol.
PD FEB
PY 2017
VL 49
IS 2
BP 303
EP 312
DI 10.1007/s11255-016-1429-2
PG 10
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA EK8CJ
UT WOS:000394151200019
PM 27704320
DA 2025-06-11
ER

PT J
AU Hwang, HJ
   Dornbos, P
   Steidemann, M
   Dunivin, TK
   Rizzo, M
   LaPres, JJ
AF Hwang, Hye Jin
   Dornbos, Peter
   Steidemann, Michelle
   Dunivin, Taylor K.
   Rizzo, Mike
   LaPres, John J.
TI Mitochondrial-targeted aryl hydrocarbon receptor and the impact of
   2,3,7,8-tetrachlorodibenzo-p-dioxin on cellular respiration and the
   mitochondrial proteome
SO TOXICOLOGY AND APPLIED PHARMACOLOGY
LA English
DT Article
DE Aryl hydrocarbon receptor; Mitochondria; Oxidative phosphorylation;
   Proteomics; SILAC; 2,3,7,8-Tetrachlorodibenzo-p-dioxin, TCDD
ID REACTIVE OXYGEN PRODUCTION; ELICITED GENE-EXPRESSION; HEPATOMA-CELLS;
   DIOXIN RECEPTOR; AH RECEPTOR; MOUSE-LIVER; CROSS-TALK; PROTEINS; IMPORT;
   ACTIVATION
AB The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor within the Per-Arnt-Sim (PAS) domain superfamily. Exposure to the most potent AHR ligand, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), is associated with various pathological effects including metabolic syndrome. While research over the last several years has demonstrated a role for oxidative stress and metabolic dysfunction in AHR-dependent TCDD-induced toxicity, the role of the mitochondria in this process has not been fully explored. Our previous research suggested that a portion of the cellular pool of AHR could be found in the mitochondria (mitoAHR). Using a protease protection assay with digitonin extraction, we have now shown that this mitoAHR is localized to the inter-membrane space (IMS) of the organelle. TCDD exposure induced a degradation of mitoAHR similar to that of cytosolic AHR. Furthermore, siRNA-mediated knockdown revealed that translocase of outer-mitochondrial membrane 20 (TOMM20) was involved in the import of AHR into the mitochondria. In addition, TCDD altered cellular respiration in an AHR-dependent manner to maintain respiratory efficiency as measured by oxygen consumption rate (OCR). Stable isotope labeling by amino acids in cell culture (SILAC) identified a battery of proteins within the mitochondrial proteome influenced by TCDD in an AHR-dependent manner. Among these, 17 proteins with fold changes 2 are associated with various metabolic pathways, suggesting a role of mitochondrial retrograde signaling in TCDD-mediated pathologies. Collectively, these studies suggest that mitoAHR is localized to the IMS and AHR-dependent TCDD-induced toxicity, including metabolic dysfunction, wasting syndrome, and hepatic steatosis, involves mitochondrial dysfunction. (C) 2016 Elsevier Inc. All rights reserved.
C1 [Hwang, Hye Jin; Dornbos, Peter; LaPres, John J.] Michigan State Univ, Dept Biochem & Mol Biol, E Lansing, MI 48824 USA.
   [Hwang, Hye Jin; LaPres, John J.] Michigan State Univ, Ctr Mitochondria Sci & Med, E Lansing, MI 48824 USA.
   [Dornbos, Peter; Steidemann, Michelle; Rizzo, Mike] Michigan State Univ, Inst Integrat Toxicol, E Lansing, MI 48824 USA.
   [Steidemann, Michelle] Michigan State Univ, Dept Pharmacol & Toxicol, E Lansing, MI 48824 USA.
   [Dunivin, Taylor K.] Michigan State Univ, Dept Microbiol & Mol Genet, E Lansing, MI 48824 USA.
   [Rizzo, Mike] Michigan State Univ, Cell & Mol Biol Grad Program, E Lansing, MI 48824 USA.
C3 Michigan State University; Michigan State University; Michigan State
   University; Michigan State University; Michigan State University;
   Michigan State University
RP LaPres, JJ (corresponding author), Michigan State Univ, Dept Biochem & Mol Biol, E Lansing, MI 48824 USA.
EM lapres@msu.edu
OI Hwang, Hye Jin/0000-0003-1083-5143
FU NIH/NIEHS grant [P42 ES04911]; MSU AgBioResearch; National Institute of
   Environmental Health Sciences Training Grant at Michigan State
   University [T32 ES007255]
FX This research is supported by the NIH/NIEHS grant P42 ES04911. Dr. J.
   LaPres is partially supported by MSU AgBioResearch. P. Dornbos is
   supported by the National Institute of Environmental Health Sciences
   Training Grant at Michigan State University (T32 ES007255).
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NR 59
TC 63
Z9 70
U1 1
U2 39
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0041-008X
EI 1096-0333
J9 TOXICOL APPL PHARM
JI Toxicol. Appl. Pharmacol.
PD AUG 1
PY 2016
VL 304
BP 121
EP 132
DI 10.1016/j.taap.2016.04.005
PG 12
WC Pharmacology & Pharmacy; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Toxicology
GA DQ8HV
UT WOS:000379451700013
PM 27105554
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Motta, VF
   Aguila, MB
   Mandarim-de-Lacerda, CA
AF Motta, Victor F.
   Aguila, Marcia B.
   Mandarim-de-Lacerda, Carlos A.
TI High-Intensity Interval Training Beneficial Effects in Diet-Induced
   Obesity in Mice: Adipose Tissue, Liver Structure, and Pancreatic Islets
SO INTERNATIONAL JOURNAL OF MORPHOLOGY
LA English
DT Article
DE HIIT; Obesity; Insulin Resistance; Hepatic Steatosis; Stereology
ID HIGH-FAT-DIET; INSULIN-RESISTANCE; METABOLIC SYNDROME; HEPATIC
   STEATOSIS; PHYSICAL-ACTIVITY; C57BL/6 MICE; DISEASE; EXERCISE; CAPACITY;
   STRESS
AB The study aimed to evaluate the impact of high-intensity interval training (HIIT) on adipose tissue, pancreatic islets and liver in mice fed high-fat diet. C57BL/6 male mice were fed one of two diets: standard chow (Lean group - LE) or a high-fat diet (Obese group - OB). After the first 12-weeks, the animals were divided into non-trained (LE-NT and OB-NT), trained groups (LET and OB-T), and started the exercise protocol. The HIIT protocol in the trained animals (LE-T and OB-T) compared to their counterparts (LE-NT and OB-NT) led to a reduction in size of the pancreatic islets (LE-T vs. LE-NT -40 %, OB-T vs. OB-NT -22 %) and to an increase in insulin immunodensity in pancreatic islet (LE-T vs. LE-NT +35 %, OB-T vs. OB-NT + 31 %). Apart from the above results, in adipose tissue, a decrease of the diameter of adipocytes (LE-T vs. LE-NT -23 %, OB-T vs. OB-NT -12 %), a reduction in adiposity index (LE-T vs. LE-NT -49 %, OB-T vs. OB-NT -24 %) and in the liver, a decrease in the context of hepatic steatosis (LE-T vs. LE-NT -57 %, OB-T vs. OB-NT -77 %). These metabolic changes characterize a benefits performance of the HIIT protocol in swimming. HIIT is able to mitigate the bad effects caused by high-fat diet, even with continued intake of this diet in an animal model. HIIT has the advantage of requiring only a few weekly sessions with short duration in each session. These benefits are important to motivate people who nowadays live with a lack of time condition for these activities.
C1 [Motta, Victor F.; Aguila, Marcia B.; Mandarim-de-Lacerda, Carlos A.] Univ Estado Rio De Janeiro, Inst Biol, Biomed Ctr, Lab Morphometry Metab & Cardiovasc Dis, Rio De Janeiro, Brazil.
C3 Universidade do Estado do Rio de Janeiro
RP Mandarim-de-Lacerda, CA (corresponding author), Univ Estado Rio de Janeiro, Inst Biol, Ctr Biomed, Lab Morfometria Metabolismo & Doenca Cardiovasc, Av 28 Setembro 87 Fds, BR-20551030 Rio De Janeiro, RJ, Brazil.
EM mandarim@uerj.br
RI Motta, Victor/H-9893-2014; Aguila, Marcia/P-2349-2019;
   Mandarim-de-Lacerda, Carlos/P-2360-2019
OI Barbosa Aguila, Marcia/0000-0003-3994-4589; Mandarim-de-Lacerda,
   Carlos/0000-0003-4134-7978; Motta, Victor Faria/0000-0002-6137-137X
FU Conselho Nacional de Ciencia e Tecnologia from Brazil [302.154/2011-6];
   Fundacao do Amparo a Pesquisa do Rio de Janeiro from Rio de Janeiro
   State [E-26/102.944/2011]
FX This research was supported by grants from the Conselho Nacional de
   Ciencia e Tecnologia from Brazil (grant # 302.154/2011-6, to CML), and
   Fundacao do Amparo a Pesquisa do Rio de Janeiro from Rio de Janeiro
   State (grant # E-26/102.944/2011, to CML). The authors are grateful to
   Michele Soares for technical assistance.
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NR 35
TC 4
Z9 4
U1 1
U2 22
PU SOC CHILENA ANATOMIA
PI TEMUCO
PA CASILLA 54-D, TEMUCO, 00000, CHILE
SN 0717-9502
EI 0717-9367
J9 INT J MORPHOL
JI Int. J. Morphol.
PD JUN
PY 2016
VL 34
IS 2
BP 684
EP 691
DI 10.4067/S0717-95022016000200042
PG 8
WC Anatomy & Morphology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Anatomy & Morphology
GA DR2RH
UT WOS:000379751100042
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Ellenbroek, D
   Kressler, J
   Cowan, RE
   Burns, PA
   Mendez, AJ
   Nash, MS
AF Ellenbroek, Dennis
   Kressler, Jochen
   Cowan, Rachel E.
   Burns, Patricia A.
   Mendez, Armando J.
   Nash, Mark S.
TI Effects of prandial challenge on triglyceridemia, glycemia, and
   pro-inflammatory activity in persons with chronic paraplegia
SO JOURNAL OF SPINAL CORD MEDICINE
LA English
DT Article
DE Feeding; Meal challenge; Glucose; Lipids
ID C-REACTIVE PROTEIN; SPINAL-CORD-INJURY; INSULIN-RESISTANCE; POSTPRANDIAL
   LIPEMIA; METABOLIC SYNDROME; ENDOTHELIAL ACTIVATION; OXIDATIVE STRESS;
   HIGH-FAT; MEN; RISK
AB Context/Objective: Exaggerated postprandial lipemia has been reported after spinal cord injury (SCI). We examined metabolite and accompanying pro-inflammatory biomarker responses to repeat feeding of typical high-fat meals in individuals with chronic paraplegia.
   Design: Descriptive trial.
   Methods: Metabolites (triglycerides, glucose, and insulin) and inflammatory biomarkers (interleukin-6 and highsensitivity C-reactive protein (hsCRP)) were measured under fasting conditions in 11 recreationally active individuals with chronic (> 1 year) paraplegia. Subjects received high-fat meals at time point 0 and again at minute 240. Antecubital venous blood was obtained at time points -30 (fasting), 0 (first meal), 30, 60, 90, 120, 240 (second meal), 360, and 480 minutes. Correlations were examined among the study variables. Exploratory subgroup analysis was performed for subjects with levels of postprandial glucose greater than > 200 mg/dl.
   Results: Triglycerides showed a significant rise 4 hours after eating. Basal inflammatory markers were elevated, and did not undergo additional change during the testing. Additionally, subjects with excessive postprandial glucose responses showed higher hsCRP levels than those having typical glucose responses both for fasting (11.8 +/- 6.5 vs. 2.9 +/- 2.7 mg/l, P=0.064) and postprandial (11.1 +/- 4.9 vs. 3.7 +/- 3.8 mg/l, P=0.018) values.
   Conclusions: Despite elevations in metabolic response markers, inflammatory markers did not change significantly after consumption of population-representative (i.e. hypercaloric) mixed-nutrient meals. Levels of fasting CRP in the high-risk range are consistent with other reports in persons with SCI and continue to pose concern for their cardiovascular disease risk. The possible association between postprandial metabolic responses and inflammatory states warrants further investigation to identify individual component risks for this secondary health hazard.
C1 [Ellenbroek, Dennis] Radboud Univ Nijmegen, Med Ctr, Dept Physiol, NL-6525 ED Nijmegen, Netherlands.
   [Kressler, Jochen; Cowan, Rachel E.; Burns, Patricia A.; Nash, Mark S.] Univ Miami, Miami Project Cure Paralysis, Miami, FL 33136 USA.
   [Cowan, Rachel E.; Nash, Mark S.] Univ Miami, Dept Neurol Surg, Miami, FL 33136 USA.
   [Mendez, Armando J.] Univ Miami, Dept Med, Miami, FL 33136 USA.
   [Mendez, Armando J.] Univ Miami, Diabet Res Inst, Miami, FL 33136 USA.
   [Nash, Mark S.] Univ Miami, Miller Sch Med, Dept Rehabil Med, Miami, FL 33136 USA.
C3 Radboud University Nijmegen; University of Miami; University of Miami;
   University of Miami; University of Miami; University of Miami
RP Kressler, J (corresponding author), Univ Miami, Miami Project Cure Paralysis, 1095 NW 14th Ter, Miami, FL 33136 USA.
EM jkressler@med.miami.edu
RI Mendez, Armando/HQY-1723-2023
OI Nash, Mark/0000-0003-4205-4130; Cowan, Rachel/0000-0002-3320-0653
FU United States Department of Education, National Institute for Disability
   and Rehabilitation Research [H133G080150]
FX This research is supported by a grant from the United States Department
   of Education, National Institute for Disability and Rehabilitation
   Research (#H133G080150).
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NR 55
TC 19
Z9 20
U1 0
U2 6
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1079-0268
EI 2045-7723
J9 J SPINAL CORD MED
JI J. Spinal Cord. Med.
PD JUL
PY 2015
VL 38
IS 4
BP 468
EP 475
DI 10.1179/2045772314Y.0000000199
PG 8
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA CL4RS
UT WOS:000356941800009
PM 24617559
OA Green Published
DA 2025-06-11
ER

PT J
AU Nanri, H
   Hara, M
   Nishida, Y
   Shimanoe, C
   Nakamura, K
   Higaki, Y
   Imaizumi, T
   Taguchi, N
   Sakamoto, T
   Horita, M
   Shinchi, K
   Kokaze, A
   Tanaka, K
AF Nanri, Hinako
   Hara, Megumi
   Nishida, Yuichiro
   Shimanoe, Chisato
   Nakamura, Kazuyo
   Higaki, Yasuki
   Imaizumi, Takeshi
   Taguchi, Naoto
   Sakamoto, Tatsuhiko
   Horita, Mikako
   Shinchi, Koichi
   Kokaze, Akatsuki
   Tanaka, Keitaro
TI Dietary Patterns and Serum Gamma-Glutamyl Transferase in Japanese Men
   and Women
SO JOURNAL OF EPIDEMIOLOGY
LA English
DT Article
DE dietary pattern; gamma-glutamyl transferase; factor analysis
ID FOOD FREQUENCY QUESTIONNAIRE; ALANINE AMINOTRANSFERASE; OXIDATIVE
   STRESS; COFFEE CONSUMPTION; METABOLIC SYNDROME; RISK DEVELOPMENT;
   ASSOCIATION; MARKERS; COHORT; GLUTAMYLTRANSFERASE
AB Background: Although specific foods and nutrients have been examined as potential determinants of serum gamma-glutamyl transferase (GGT) concentrations, the relationship between dietary patterns and GGT remains unknown. The present cross-sectional study aimed to determine relationships between dietary patterns and GGT concentrations, and the effects of lifestyle factors on GGT.
   Methods: Relationships between dietary patterns and GGT were analyzed in 9803 Japanese individuals (3723 men and 6080 women age 40-69 years) without a history of liver diseases or elevated serum aminotransferase. We examined major dietary patterns by factor analysis of 46 items determined from a validated, short food frequency questionnaire.
   Results: We defined dietary patterns as healthy, Western, seafood, bread, and dessert. The healthy pattern was inversely related to GGT in men (odds ratio [OR] for highest vs lowest quartile, 0.72; 95% confidence interval [CI], 0.57-0.92; P < 0.01 for trend) and women (OR 0.82; 95% CI, 0.66-1.0; P = 0.05 for trend), whereas the seafood pattern was positively related to GGT in men (OR 1.27; 95% CI, 1.01-1.61; P = 0.03 for trend) and women (OR 1.21; 95% CI, 0.98-1.49; P = 0.05 for trend). Male-specific inverse associations with GGT were found for bread and dessert patterns (OR 0.63; 95% CI, 0.50-0.80 and OR 0.53; 95% CI, 0.41-0.68, respectively; P < 0.01 for both trends). Seafood or bread patterns and alcohol consumption significantly interacted with GGT in men (P = 0.03 and < 0.01 for interaction, respectively) and between the dessert pattern and body mass index or smoking habit in women (P = 0.03 and < 0.01, respectively, for interaction).
   Conclusions: Dietary patterns may be important determinants of GGT, and their possible clinical implications warrant further investigation.
C1 [Nanri, Hinako; Kokaze, Akatsuki] Showa Univ, Sch Med, Dept Publ Hlth, Tokyo 1428555, Japan.
   [Hara, Megumi; Nishida, Yuichiro; Shimanoe, Chisato; Imaizumi, Takeshi; Taguchi, Naoto; Horita, Mikako; Tanaka, Keitaro] Saga Univ, Fac Med, Dept Prevent Med, Saga 840, Japan.
   [Nakamura, Kazuyo] St Marys Coll, Fac Nursing, Kurume, Fukuoka, Japan.
   [Higaki, Yasuki] Fukuoka Univ, Fac Sports & Hlth Sci, Lab Exercise Physiol, Fukuoka 81401, Japan.
   [Sakamoto, Tatsuhiko] Fukuoka Prefectural Govt, Chikushi Off Hlth Human Serv & Environm Issues, Fukuoka, Japan.
   [Shinchi, Koichi] Saga Univ, Fac Med, Div Int Hlth & Nursing, Saga 840, Japan.
C3 Showa University; Saga University; Fukuoka University; Saga University
RP Nanri, H (corresponding author), Showa Univ, Sch Med, Dept Publ Hlth, Shinagawa Ku, 1-5-8 Hatanodai, Tokyo 1428555, Japan.
EM nanrih@med.showa-u.ac.jp
RI Nishida, Yuichiro/H-8791-2019
OI Hara, Megumi/0000-0002-8708-3237; Nishida, Yuichiro/0000-0003-2320-7234;
   Shinchi, Koichi/0000-0003-2367-7607; Nanri, Hinako/0000-0001-7263-3550;
   Shimanoe, Chisato/0000-0002-3561-9538
FU Ministry of Education, Culture, Sports, Science and Technology, Japan
   [17015018, 221S0001, 20249038, 19200049, 20689014, 18790380, 25870517];
   Grants-in-Aid for Scientific Research [20689014, 18790380, 26293141,
   25870517, 20249038, 221S0001] Funding Source: KAKEN
FX This study was supported in part by Grants-in-Aid for Scientific
   Research on Special Priority Areas of Cancer (No. 17015018) and
   Innovative Areas (No. 221S0001), Scientific Research (A) (No. 20249038),
   Strategic Research Infrastructure (No. 19200049), and Young Scientists
   (A) (No. 20689014), (B) (No. 18790380), (B) (No. 25870517) from the
   Ministry of Education, Culture, Sports, Science and Technology, Japan.
   We are grateful to Shinkan Tokudome at the National Institute of Health
   and Nutrition (formerly Nagoya City University), Chiho Goto at Nagoya
   Bunri University, Nahomi Imaeda at Nagoya Women's University, Yuko
   Tokudome at Nagoya University of Arts and Sciences, Masato Ikeda at the
   University of Occupational and Environmental Health, and Shinzo Maki at
   the Aichi Prefectural Dietetic Association for granting us permission to
   use the FFQ and for providing the SAS program for estimating nutrient
   intake. The contributions of authors were as follows: H.N. contributed
   to data collection, data analysis, and manuscript preparation; Y.N.,
   C.S., K.N., T.I., N.T., T.S., M. Horita, K.S., and A.K. contributed to
   data collection; M. Hara and Y.H. contributed to study design, data
   collection, and data management; and K.T. contributed to study design,
   data collection, statistical programming support, and manuscript
   preparation.
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NR 36
TC 15
Z9 17
U1 0
U2 1
PU JAPAN EPIDEMIOLOGICAL ASSOC
PI TOKYO
PA HONGO MT BLDG, 4 FL, 7-2-2, HONGO, BUNKYO-KU, TOKYO, JAPAN
SN 0917-5040
J9 J EPIDEMIOL
JI J. Epidemiol.
PD MAY
PY 2015
VL 25
IS 5
BP 378
EP 386
DI 10.2188/jea.JE20140158
PG 9
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA CG8VB
UT WOS:000353591700005
PM 25787241
OA gold, Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Yogalakshmi, B
   Bhuvaneswari, S
   Sreeja, S
   Anuradha, CV
AF Yogalakshmi, Baskaran
   Bhuvaneswari, Saravanan
   Sreeja, S.
   Anuradha, Carani Venkatraman
TI Grape seed proanthocyanidins and metformin act by different mechanisms
   to promote insulin signaling in rats fed high calorie diet
SO JOURNAL OF CELL COMMUNICATION AND SIGNALING
LA English
DT Article
DE High fat-fructose diet; Grape seed proanthocyanidins; Metformin; Insulin
   signaling; Inflammation
ID ACTIVATED PROTEIN-KINASE; RECEPTOR SUBSTRATE-1; COMBINATION THERAPY;
   OXIDATIVE STRESS; ADIPOSE-TISSUE; RESISTANCE; INFLAMMATION;
   PHOSPHORYLATION; LEPTIN; INHIBITION
AB Key pathways like insulin signaling, AMP activated kinase (AMPK) activation and inflammatory signaling are involved in the complex pathological network of hepatic insulin resistance. Our aim is to investigate whether grape seed proanthocyanidins (GSP) and metformin (MET) target any of these pathways in insulin resistant rat liver. Albino Wistar rats were rendered insulin resistant by feeding a high fat-fructose diet (HFFD). Either GSP (100 mg/kg b.w), MET(50 mg/kg b.w) or both were administered to insulin resistant rats as therapeutic options. HFFD-feeding caused hyperglycemia, hyperinsulinemia, increased gluconeogenesis, decreased tyrosine phosphorylation of insulin receptor-beta (IR-beta) and insulin receptor substrate-1 (IRS-1) and increased serine phosphorylation of IRS-1. The association of p85 alpha subunit of phosphotidyl inositol 3 kinase(PI3K) with IRS-1 and subsequent Akt phosphorylation were reduced while the expression of mitogen activated protein kinases (MAPK) were increased in HFFD rats. Both MET and GSP reduced hyperglycemia and hyperinsulinemia and improved glycolysis, tyrosine phosphorylation of IR-beta and IRS-1, IRS-1-PI3K association and Akt activation. However, activation of tumor necrosis factor-a, interleukin-6, leptin and suppressor of cytokine signaling-3 and reduction in adiponectin caused by chronic HFFD feeding were reversed by GSP better than by MET. Activation of AMPK by GSP was much less compared to that by MET. These findings suggest that GSP might activate PI3K pathway and promote insulin action by reducing serine kinase activation and cytokine signaling and MET by targeting AMPK. The beneficial effects were enhanced during combination therapy. Thus, combination therapy with MET and GSP may be considered for the management of metabolic syndrome.
C1 [Yogalakshmi, Baskaran; Bhuvaneswari, Saravanan; Sreeja, S.; Anuradha, Carani Venkatraman] Annamalai Univ, Dept Biochem & Biotechnol, Annamalainagar 608002, Tamil Nadu, India.
C3 Annamalai University
RP Anuradha, CV (corresponding author), Annamalai Univ, Dept Biochem & Biotechnol, Annamalainagar 608002, Tamil Nadu, India.
EM cvaradha@hotmail.com
RI Venkatraman, Anuradha/U-8717-2019; S, SREEJA/KIK-7275-2024; s,
   bhuvaneswari/NHP-5263-2025
OI Carani Venkatraman, Anuradha/0000-0001-9924-2533; S,
   SREEJA/0000-0002-1667-7492
FU Indian Council of Medical Research (ICMR), New Delhi
FX We gratefully acknowledge the Indian Council of Medical Research (ICMR),
   New Delhi, for providing financial assistance in the form of Senior
   Research Fellowship (SRF) to the first author, Yogalakshmi. B.
CR Aguirre V, 2000, J BIOL CHEM, V275, P9047, DOI 10.1074/jbc.275.12.9047
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NR 29
TC 27
Z9 30
U1 0
U2 17
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1873-9601
EI 1873-961X
J9 J CELL COMMUN SIGNAL
JI J. Cell Commun. Signal
PD MAR
PY 2014
VL 8
IS 1
BP 13
EP 22
DI 10.1007/s12079-013-0210-x
PG 10
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA CL7TW
UT WOS:000357175600004
PM 24026800
OA Green Published
DA 2025-06-11
ER

PT J
AU Mochizuki, K
   Hariya, N
   Miyauchi, R
   Misaki, Y
   Ichikawa, Y
   Goda, T
AF Mochizuki, Kazuki
   Hariya, Natsuyo
   Miyauchi, Rie
   Misaki, Yasumi
   Ichikawa, Yoko
   Goda, Toshinao
TI Self-reported faster eating associated with higher ALT activity in
   middle-aged, apparently healthy Japanese women
SO NUTRITION
LA English
DT Article
DE Faster eating; ALT; Japanese women; Apparently healthy women
ID GAMMA-GLUTAMYL-TRANSFERASE; DIET HISTORY QUESTIONNAIRE; ALANINE
   AMINOTRANSFERASE; INSULIN-RESISTANCE; METABOLIC SYNDROME; ENERGY-INTAKE;
   OXIDATIVE STRESS; LIVER-ENZYMES; BODY-WEIGHT; FAST LEADS
AB Objective: Faster eating and elevated circulating activity of alanine aminotransferase (ALT), a marker for liver injury, are risk factors for the development of obesity and type 2 diabetes mellitus, and their complications. The aim of this study was to examine the association between self-reported eating rate and circulating ALT activity in apparently healthy middle-aged Japanese women.
   Methods: We conducted a cross-sectional study of 900 apparently healthy women ages 40 to 64 y (mean E +/- SD, 53.1 +/- 7.1 y) who participated in health check-ups in Japan. We analyzed their clinical serum parameters and lifestyle factors, including self-reported eating rate. Associations between liver injury markers (ALT, y-glutamyl transpeptidase [GTP], and aspartate aminotransferase [AST]), other clinical parameters and lifestyle factors were analyzed using Tukey's multiple range test following analysis of variance and analysis of covariance for three groups, divided by self-reported eating rates. The associations between self-reported faster eating and ALT activity and lifestyle factors were analyzed by multivariate logistic regression analyses.
   Results: ALT activity, but not y-GTP or AST activities, was higher in participants who reported relatively fast/very fast eating than in those who reported medium eating after adjusting for age, alcohol intake, energy intake, smoking, and physical activity. The odds ratio of eating rate for ALT activity in T3 (18-128 U/L) compared with T1 (3-12 U/L) was 1.67 (P < 0.01), but the association disappeared after adjustment for body mass index (BMI).
   Conclusions: ALT activity is positively associated with faster eating, but is dependent on BMI in middle-aged, apparently healthy Japanese women. (C) 2014 Elsevier Inc. All rights reserved.
C1 [Mochizuki, Kazuki] Univ Yamanashi, Res Branch Food & Nutr Sci, Dept Local Produce & Food Sci, Fac Life & Environm Sci, Yamanashi, Japan.
   [Mochizuki, Kazuki; Miyauchi, Rie; Misaki, Yasumi; Goda, Toshinao] Univ Shizuoka, Sch Food & Nutr Sci, Lab Nutr Physiol, Shizuoka 4228526, Japan.
   [Hariya, Natsuyo] Univ Yamanashi, Interdisciplinary Grad Sch Med & Engn, Yamanashi, Japan.
   [Ichikawa, Yoko] Univ Shizuoka, Sch Food & Nutr Sci, Lab Food Management, Shizuoka 4228526, Japan.
C3 University of Yamanashi; University of Shizuoka; University of
   Yamanashi; University of Shizuoka
RP Goda, T (corresponding author), Univ Shizuoka, Sch Food & Nutr Sci, Lab Nutr Physiol, Shizuoka 4228526, Japan.
EM gouda@u-shizuoka-ken.ac.jp
RI Goda, Toshinao/C-8981-2014
FU Global COE Program for the Center of Excellence for Innovation in Human
   Health Sciences from the Ministry of Education, Culture, Sports, Science
   and Technology of Japan [24650448]; Grants-in-Aid for Scientific
   Research [24650448] Funding Source: KAKEN
FX We acknowledge Drs. S. Sasaki and K. Murakami for providing the Brief
   Self-administered Diet History Questionnaire. This study was financially
   supported by the Global COE Program for the Center of Excellence for
   Innovation in Human Health Sciences from the Ministry of Education,
   Culture, Sports, Science and Technology of Japan, and a Grant-in-Aid for
   Challenging Exploratory Research (24650448) from the Ministry of
   Education, Culture, Sports, Science and Technology of Japan.
CR Bo S, 2005, WORLD J GASTROENTERO, V11, P7109, DOI 10.3748/wjg.v11.i45.7109
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NR 38
TC 14
Z9 16
U1 1
U2 11
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0899-9007
EI 1873-1244
J9 NUTRITION
JI Nutrition
PD JAN
PY 2014
VL 30
IS 1
BP 69
EP 74
DI 10.1016/j.nut.2013.07.016
PG 6
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 281DF
UT WOS:000329079400011
PM 24290601
DA 2025-06-11
ER

PT J
AU Tobar, A
   Ori, Y
   Benchetrit, S
   Milo, G
   Herman-Edelstein, M
   Zingerman, B
   Lev, N
   Gafter, U
   Chagnac, A
AF Tobar, Ana
   Ori, Yaacov
   Benchetrit, Sydney
   Milo, Gai
   Herman-Edelstein, Michal
   Zingerman, Boris
   Lev, Netta
   Gafter, Uzi
   Chagnac, Avry
TI Proximal Tubular Hypertrophy and Enlarged Glomerular and Proximal
   Tubular Urinary Space in Obese Subjects with Proteinuria
SO PLOS ONE
LA English
DT Article
ID INDEPENDENT RISK-FACTOR; BODY-MASS INDEX; METABOLIC SYNDROME; RENAL
   HEMODYNAMICS; STRUCTURAL-CHANGES; DIABETES-MELLITUS; MECHANICAL-STRESS;
   GROWTH-FACTORS; KIDNEY; HYPERFILTRATION
AB Background: Obesity is associated with glomerular hyperfiltration, increased proximal tubular sodium reabsorption, glomerular enlargement and renal hypertrophy. A single experimental study reported an increased glomerular urinary space in obese dogs. Whether proximal tubular volume is increased in obese subjects and whether their glomerular and tubular urinary spaces are enlarged is unknown.
   Objective: To determine whether proximal tubules and glomerular and tubular urinary space are enlarged in obese subjects with proteinuria and glomerular hyperfiltration.
   Methods: Kidney biopsies from 11 non-diabetic obese with proteinuria and 14 non-diabetic lean patients with a creatinine clearance above 50 ml/min and with mild or no interstitial fibrosis were retrospectively analyzed using morphometric methods. The cross-sectional area of the proximal tubular epithelium and lumen, the volume of the glomerular tuft and of Bowman's space and the nuclei number per tubular profile were estimated.
   Results: Creatinine clearance was higher in the obese than in the lean group (P=0.03). Proteinuria was similarly increased in both groups. Compared to the lean group, the obese group displayed a 104% higher glomerular tuft volume (P=0.001), a 94% higher Bowman's space volume (P=0.003), a 33% higher cross-sectional area of the proximal tubular epithelium (P=0.02) and a 54% higher cross-sectional area of the proximal tubular lumen (P=0.01). The nuclei number per proximal tubular profile was similar in both groups, suggesting that the increase in tubular volume is due to hypertrophy and not to hyperplasia.
   Conclusions: Obesity-related glomerular hyperfiltration is associated with proximal tubular epithelial hypertrophy and increased glomerular and tubular urinary space volume in subjects with proteinuria. The expanded glomerular and urinary space is probably a direct consequence of glomerular hyperfiltration. These effects may be involved in the pathogenesis of obesity-related renal disease.
C1 [Tobar, Ana] Rabin Med Ctr, Dept Pathol, Petah Tiqwa, Israel.
   [Ori, Yaacov; Milo, Gai; Herman-Edelstein, Michal; Zingerman, Boris; Lev, Netta; Gafter, Uzi; Chagnac, Avry] Rabin Med Ctr, Dept Hypertens & Nephrol, Petah Tiqwa, Israel.
   [Benchetrit, Sydney] Meir Med Ctr, Dept Nephrol, Kefar Sava, Israel.
   [Tobar, Ana; Ori, Yaacov; Benchetrit, Sydney; Milo, Gai; Zingerman, Boris; Lev, Netta; Gafter, Uzi; Chagnac, Avry] Tel Aviv Univ, Sackler Sch Med, IL-69978 Tel Aviv, Israel.
C3 Rabin Medical Center; Rabin Medical Center; Tel Aviv University; Sackler
   Faculty of Medicine; Tel Aviv University; Sackler Faculty of Medicine
RP Chagnac, A (corresponding author), Rabin Med Ctr, Dept Hypertens & Nephrol, Petah Tiqwa, Israel.
EM Chagnac@clalit.org.il
CR Amer Diabet Assoc, 2010, DIABETES CARE, V33, pS11, DOI [10.2337/dc10-S011, 10.2337/dc10-S062, 10.2337/dc13-S011, 10.2337/dc13-S067, 10.2337/dc11-S011, 10.2337/dc14-S081, 10.2337/dc12-s064, 10.2337/dc11-S062, 10.2337/dc12-s011]
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NR 51
TC 82
Z9 89
U1 0
U2 5
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD SEP 25
PY 2013
VL 8
IS 9
AR e75547
DI 10.1371/journal.pone.0075547
PG 9
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 228VC
UT WOS:000325218700098
PM 24086563
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Klop, B
   Jukema, JW
   Rabelink, TJ
   Cabezas, MC
AF Klop, B.
   Jukema, J. Wouter
   Rabelink, T. J.
   Cabezas, M. Castro
TI A physician's guide for the management of hypertriglyceridemia: the
   etiology of hypertriglyceridemia determines treatment strategy
SO PANMINERVA MEDICA
LA English
DT Article
DE Hyperlipidemias; Triglycerides; Apolipoproteins B
ID HIGH-DENSITY-LIPOPROTEIN; CORONARY-HEART-DISEASE; FAMILIAL COMBINED
   HYPERLIPIDEMIA; TYPE-2 DIABETES-MELLITUS; GENOME-WIDE ASSOCIATION;
   POSTPRANDIAL LIPID-METABOLISM; POLYUNSATURATED FATTY-ACIDS;
   CHRONIC-RENAL-FAILURE; CARDIOVASCULAR-DISEASE; MYOCARDIAL-INFARCTION
AB Hypertriglyceridemia is a common lipid disorder associated to different, highly prevalent metabolic derangements like diabetes mellitus, the metabolic syndrome and obesity. The choice of treatment depends on the underlying pathogenesis and the consequences for atherosclerosis or pancreatitis. A family history, physical examination and analysis of the lipid profile including measurement of apolipoprotein B or non-HDL-C are necessary to establish the underlying primary or secondary cause. Due to physiological diurnal variations of triglycerides (TG), the time of measurement (fasting or postprandial) should be taken into account when evaluating TG values. Increased awareness arises concerning the impact of postprandial hypertriglyceridemia on the development of atherosclerosis. Hypertriglyceridemia is strongly associated to postprandial hyperlipidemia, remnant accumulation, increased small dense LDL concentrations, low HDL-C, increased oxidative stress, endothelial dysfunction, leukocyte activation and insulin resistance. All these factors are strongly linked to the development of atherosclerosis. Treatment should be aimed at reducing the secretion of triglyceride-rich lipoproteins, increasing intravascular lipolysis and reducing the number of circulating remnants. The main intervention is a change of lifestyle with decreased alcohol consumption, increased physical activity, dietary changes and, if applicable, adaptation of used medication. Fibrates, fish oil and nicotinic acid are the first choice of treatment in sporadic and familial hypertriglyceridemia to reduce the risk of pancreatitis, whereas high dose statins, sometimes in combination with fibrates, nicotinic acid, or fish oil capsules, are indicated for familial combined hyperlipidemia. Statins are necessary to reach low LDL-C concentrations in patients with type 2 diabetes mellitus and statin dosage should be increased when hypertriglyceridemia is present to reach secondary treatment targets for apolipoprotein B or non-HDL-C. Finally, family screening is mandatory to detect familial lipid disorders for early intervention in other family members.
C1 [Klop, B.; Cabezas, M. Castro] Sint Franciscus Gasthuis Rotterdam, Diabet & Vasc Ctr, Dept Internal Med, Rotterdam, Netherlands.
   [Jukema, J. Wouter] Leiden Univ, Med Ctr, Dept Cardiol, Leiden, Netherlands.
   [Rabelink, T. J.] Leiden Univ, Dept Nephrol, Leiden, Netherlands.
C3 Franciscus Gasthuis; Leiden University; Leiden University Medical Center
   (LUMC); Leiden University - Excl LUMC; Leiden University; Leiden
   University - Excl LUMC
RP Cabezas, MC (corresponding author), St Franciscus Gasthuis Rotterdam, Dept Internal Med, Ctr Diabet & Vasc Med, POB 10900, NL-3004 BA Rotterdam, Netherlands.
EM m.castrocabezas@sfg.nl
RI Jukema, J. Wouter/ABD-6503-2021; Rabelink, Ton/A-5316-2008
OI Jukema, J. Wouter/0000-0002-3246-8359; Rabelink, Ton/0000-0001-6780-5186
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NR 136
TC 34
Z9 41
U1 0
U2 13
PU EDIZIONI MINERVA MEDICA
PI TURIN
PA CORSO BRAMANTE 83-85 INT JOURNALS DEPT., 10126 TURIN, ITALY
SN 0031-0808
EI 1827-1898
J9 PANMINERVA MED
JI Panminerva Medica
PD JUN
PY 2012
VL 54
IS 2
BP 91
EP 103
PG 13
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 961XF
UT WOS:000305502100005
PM 22525564
DA 2025-06-11
ER

PT J
AU O'Neil, CE
   Keast, DR
   Fulgoni, VL
   Nick, TA
AF O'Neil, Carol E.
   Keast, Debra R.
   Fulgoni, Victor L., III
   Nick, Theresa A.
TI Tree nut consumption improves nutrient intake and diet quality in US
   adults: an analysis of National Health and Nutrition Examination Survey
   (NHANES) 1999-2004
SO ASIA PACIFIC JOURNAL OF CLINICAL NUTRITION
LA English
DT Article
DE tree nuts; nutrient intake; dietary adequacy; healthy eating index-2005;
   NHANES
ID CORONARY-HEART-DISEASE; ALPHA-TOCOPHEROL INTAKE; VITAMIN-E; MAGNESIUM
   INTAKE; CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; OXIDATIVE STRESS;
   RISK; PLASMA; WOMEN
AB Recent epidemiologic studies assessing tree nut (almonds. Brazil nuts, cashews, hazelnuts, macadamia nuts, pecans, pine nuts, pistachios, and walnuts) consumption and the association with nutrient intake and diet quality are lacking. This study determined the association of tree nut consumption and nutrient intake and diet quality using a nationally representative sample of adults. Adults 19+ years (y) (n=13,292) participating in the 19992004 National Health and Nutrition Examination Survey were used. Intake was determined from 24-hour diet recalls; tree nut consumers were defined as those consuming >= 1/4 ounce/day (7.09 g). Means, standard errors, and ANOVA (adjusted for covariates) were determined using appropriate sample weights. Diet quality was measured using the Healthy Eating Index-2005. Among consumers, mean intake of tree nuts/tree nut butters was 1.19 +/- 0.04 oz/d versus 0.01 +/- 0.00 oz/d for non-consumers. In this study, 5.5 +/- 0.3% of individuals 19-50 y (n=7,049) and 8.4 +/- 0.6% of individuals 51+ y (n=6,243) consumed tree nuts/tree nut butters. Mean differences (p<0.01) between tree nut consumers and non-consumers of adult shortfall nutrients were: fiber (+5.0 g/d), vitamin E (+3.7 mg AT/d), calcium (+73 mg/d), magnesium (+95 mg/d), and potassium (+260 mg/d). Tree nut consumers had lower sodium intake (-157 mg/d, p<0.01). Diet quality was significantly higher in tree nut consumers (58.0+/-0.4 vs. 48.5+/-0.3, p<0.01). Tree nut consumption was associated with a higher overall diet quality score and improved nutrient intakes. Specific dietary recommendations for nut consumption should be provided for consumers.
C1 [O'Neil, Carol E.] LSU AgCtr, Baton Rouge, LA 70803 USA.
   [Keast, Debra R.] Food & Nutr Database Res Inc, Okemos, MI USA.
   [Fulgoni, Victor L., III] Nutr Impact LLC, Battle Creek, MI USA.
   [Nick, Theresa A.] Baylor Coll Med, Dept Pediat, USDA ARS, Childrens Nutr Res Ctr, Houston, TX 77030 USA.
C3 Louisiana State University System; Louisiana State University; Nutrition
   Impact, LLC; United States Department of Agriculture (USDA); Baylor
   College of Medicine
RP O'Neil, CE (corresponding author), LSU AgCtr, 261 Knapp Hall, Baton Rouge, LA 70803 USA.
EM coneil1@lsu.edu
FU International Tree Nut Council Nutrition Research and Education
   Foundation; USDA
FX This work was supported by the International Tree Nut Council Nutrition
   Research and Education Foundation and USDA. VL Fulgoni III is a
   consultant to the food industry and has provided consulting services on
   nutrition/health related issues for the Almond Board of California and
   the International Tree Nut Nutrition Research and Education Foundation.
   The other authors have no disclosures other than the stated funding for
   this research.
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   WHAT WE EAT AM 1994
   NHANES 2003 2004 DIE
   MEDITERRANEAN FOOD G
NR 55
TC 70
Z9 78
U1 0
U2 19
PU H E C PRESS, HEALTHY EATING CLUB PTY LTD
PI MCKINNON
PA PO BOX 4121, MCKINNON, VIC 3204, AUSTRALIA
SN 0964-7058
EI 1440-6047
J9 ASIA PAC J CLIN NUTR
JI Asia Pac. J. Clin. Nutr.
PY 2010
VL 19
IS 1
BP 142
EP 150
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 574RH
UT WOS:000276009900021
PM 20200000
DA 2025-06-11
ER

PT J
AU Honda, T
   Kaikita, K
   Tsujita, K
   Hayasaki, T
   Matsukawa, M
   Fuchigami, S
   Sugiyama, S
   Sakashita, N
   Ogawa, H
   Takeya, M
AF Honda, Tsuyoshi
   Kaikita, Koichi
   Tsujita, Kenichi
   Hayasaki, Takanori
   Matsukawa, Masakazu
   Fuchigami, Shunichiro
   Sugiyama, Seigo
   Sakashita, Naomi
   Ogawa, Hisao
   Takeya, Motohiro
TI Pioglitazone, a peroxisome proliferator-activated receptor-γ agonist,
   attenuates myocardial ischemia-reperfusion injury in mice with metabolic
   disorders
SO JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
LA English
DT Article
DE metabolic syndrome; myocardial infarction; cytokines; pioglitazone;
   macrophages
ID INFLAMMATORY CHANGES; INSULIN-RESISTANCE; TARGETED DELETION; OXIDATIVE
   STRESS; INFARCT SIZE; VISCERAL FAT; PPAR-GAMMA; OBESITY; RISK;
   ROSIGLITAZONE
AB Although considerable attention has focused on obesity, insulin resistance and abnormal lipid metabolism as coronary risk factors, it remains unclear how these pathogenic factors affect the inflammatory response after myocardial ischemia-reperfusion. This study was conducted to evaluate whether these metabolic disorders exacerbate myocardial ischemia-reperfusion injury, and to determine if ischemia-reperfusion injury could be modified with the thiazolidinedione, pioglitazone. Experiments were performed in KK-A(y) and C57BL/6J mice subjected to 40 min of ischemia followed by reperfusion. Infiltration of inflammatory cells in ischemic myocardium, and infarct size 3 days after reperfusion were significantly higher in KK-A(y) than C57BL/6J mice (p < 0.05 and p < 0.001, respectively). Furthermore, expression of chemokines, inflammatory cytokines and extracellular matrix proteins in ischemic myocardium was significantly higher in KK-A(y) than C57BL/6J mice I day after reperfusion. Pioglitazone treatment of KK-A(y) mice for 14 days significantly reduced the accumulation of inflammatory cells in ischemic myocardium, and infarct size 3 days after reperfusion compared to vehicle treatment (p < 0.05 and p < 0.05, respectively). Pioglitazone also attenuated expression of chemokines, inflammatory cytokines and extracellular matrix proteins in ischemic myocardium I day after reperfusion. In vitro experiments demonstrated that tumor necrosis factor-alpha (TNF-alpha) was significantly higher in cultured peritoneal macrophages from KK-A(y) than C57BL/6J mice, and pioglitazone significantly reduced TNF-alpha in macrophages from both types of mice. These findings suggest that metabolic disorders exacerbate ischemia-reperfusion injury as a result of overexpression of inflammatory mediators, and this effect might be improved, in part by the anti-inflammatory effects of pioglitazone. (C) 2008 Elsevier Inc. All rights reserved.
C1 [Honda, Tsuyoshi; Kaikita, Koichi; Tsujita, Kenichi; Hayasaki, Takanori; Matsukawa, Masakazu; Fuchigami, Shunichiro; Sugiyama, Seigo; Ogawa, Hisao] Kumamoto Univ, Grad Sch Med Sci, Dept Cardiovasc Med, Kumamoto 8608556, Japan.
   [Honda, Tsuyoshi; Fuchigami, Shunichiro; Sakashita, Naomi; Takeya, Motohiro] Kumamoto Univ, Grad Sch Med Sci, Dept Cell Pathol, Kumamoto 8608556, Japan.
C3 Kumamoto University; Kumamoto University
RP Kaikita, K (corresponding author), Kumamoto Univ, Grad Sch Med Sci, Dept Cardiovasc Med, 1-1-1 Honjo, Kumamoto 8608556, Japan.
EM kaikitak@kumamoto-u.ac.jp
RI Tsujita, Kenichi/AAG-4562-2021
OI Tsujita, Kenichi/0000-0002-4314-259X
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NR 45
TC 39
Z9 42
U1 0
U2 1
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0022-2828
EI 1095-8584
J9 J MOL CELL CARDIOL
JI J. Mol. Cell. Cardiol.
PD MAY
PY 2008
VL 44
IS 5
BP 915
EP 926
DI 10.1016/j.yjmcc.2008.03.004
PG 12
WC Cardiac & Cardiovascular Systems; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Cell Biology
GA 313HJ
UT WOS:000256731400008
PM 18436235
DA 2025-06-11
ER

PT J
AU Wu, KH
   Lee, JI
   Lee, YC
   Shen, JT
   Wang, HS
   Tsao, YH
   Wu, YH
   Huang, SP
   Chen, SC
   Jhan, JH
   Geng, JH
AF Wu, Kuan-Hsien
   Lee, Jia-In
   Lee, Yung-Chin
   Shen, Jung-Tsung
   Wang, Hsun-Shuan
   Tsao, Yao-Hsuan
   Wu, Yi-Hsuan
   Huang, Shu-Pin
   Chen, Szu-Chia
   Jhan, Jhen-Hao
   Geng, Jiun-Hung
TI Habitual tea consumption is associated with a lower prevalence of kidney
   stone disease in postmenopausal women
SO PEERJ
LA English
DT Article
DE Epidemiologic study; Cross-sectional study; Kidney stone disease;
   Menopause; Post menopausal women; Tea
ID NUTRITION EXAMINATION SURVEY; GREEN TEA; METABOLIC SYNDROME; OXIDATIVE
   STRESS; NATIONAL-HEALTH; HORMONE-THERAPY; RISK; NEPHROLITHIASIS;
   MENOPAUSE
AB Background: Menopause is associated with an increased risk of kidney stone disease (KSD). However, for postmenopausal women, how to avoid KSD has rarely been studied. The aim of this study was to explore whether drinking tea is associated with a reduction in the prevalence of KSD in postmenopausal women. Methods: We collected 11,484 postmenopausal women from the Taiwan Biobank, and used questionnaires to obtain information on tea drinking, KSD, and comorbidities. The participants were divided into two groups according to habitual tea consumption: tea-drinking and non-tea-drinking groups. The association between habitual tea consumption and KSD was examined by logistic regression analysis. Results: There were 2,035 postmenopausal women in the tea-drinking group and 9,449 postmenopausal women in the non-tea-drinking group. The mean age of all participants was 61 years. Compared to the non-tea-drinking group, the tea-drinking group had a significantly lower prevalence of KSD (7% vs. 5%). The odds ratio (OR) of KSD was lower in those who habitually drank tea than in those who did not (OR = 0.78; 95% confidence interval [CI] [0.63 to 0.96]) after adjusting for confounders. Moreover, postmenopausal women with a daily intake of two cups of tea or more had a 30% reduced risk of KSD compared to those who did not habitually drink tea (OR = 0.71, 95% CI [0.56 to 0.90]). Conclusions: Our results suggest that habitual tea drinking may be associated with a reduction in the prevalence of KSD in postmenopausal women. Further studies are warranted to investigate the protective effect of tea on the development of KSD.
C1 [Wu, Kuan-Hsien; Lee, Yung-Chin; Shen, Jung-Tsung; Wang, Hsun-Shuan; Tsao, Yao-Hsuan; Wu, Yi-Hsuan; Jhan, Jhen-Hao; Geng, Jiun-Hung] Kaohsiung Municipal Siaogang Hosp, Dept Urol, Kaohsiung, Taiwan.
   [Wu, Kuan-Hsien; Lee, Yung-Chin; Wang, Hsun-Shuan; Tsao, Yao-Hsuan; Wu, Yi-Hsuan; Huang, Shu-Pin; Jhan, Jhen-Hao; Geng, Jiun-Hung] Kaohsiung Med Univ Hosp, Dept Urol, Kaohsiung, Taiwan.
   [Lee, Jia-In] Kaohsiung Med Univ Hosp, Dept Psychiat, Kaohsiung, Taiwan.
   [Huang, Shu-Pin; Jhan, Jhen-Hao; Geng, Jiun-Hung] Kaohsiung Med Univ, Grad Inst Clin Med, Coll Med, Kaohsiung, Taiwan.
   [Chen, Szu-Chia] Kaohsiung Municipal Siaogang Hosp, Dept Internal Med, Kaohsiung, Taiwan.
   [Chen, Szu-Chia] Kaohsiung Med Univ Hosp, Dept Internal Med, Div Nephrol, Kaohsiung, Taiwan.
   [Chen, Szu-Chia] Kaohsiung Med Univ, Coll Med, Fac Med, Kaohsiung, Taiwan.
   [Chen, Szu-Chia; Geng, Jiun-Hung] Kaohsiung Med Univ, Res Ctr Environm Med, Kaohsiung, Taiwan.
C3 Kaohsiung Medical University; Kaohsiung Municipal Siao-Gang Hospital;
   Kaohsiung Medical University; Kaohsiung Medical University Hospital;
   Kaohsiung Medical University; Kaohsiung Medical University Hospital;
   Kaohsiung Medical University; Kaohsiung Medical University; Kaohsiung
   Municipal Siao-Gang Hospital; Kaohsiung Medical University; Kaohsiung
   Medical University Hospital; Kaohsiung Medical University; Kaohsiung
   Medical University
RP Geng, JH (corresponding author), Kaohsiung Municipal Siaogang Hosp, Dept Urol, Kaohsiung, Taiwan.; Geng, JH (corresponding author), Kaohsiung Med Univ Hosp, Dept Urol, Kaohsiung, Taiwan.; Geng, JH (corresponding author), Kaohsiung Med Univ, Grad Inst Clin Med, Coll Med, Kaohsiung, Taiwan.; Geng, JH (corresponding author), Kaohsiung Med Univ, Res Ctr Environm Med, Kaohsiung, Taiwan.
EM u9001090@hotmail.com
RI Huang, Shu-Pin/D-5286-2009; Lee, Yung-Chin/A-2027-2010; Jhan,
   Jhen-Hao/AGG-3865-2022; GENG, JIUNHUNG/AAB-2322-2022; 蘇,
   河名/AAE-9843-2019
OI Jhan, Jhen-Hao/0000-0003-3239-0712
FU Research Center for Environmental Medicine, Kaohsiung Medical
   University, Kaohsiung, Taiwan from The Featured Areas Research Center
   Program within Ministry of Education (MOE) in Taiwan; Kaohsiung Medical
   University Research Center Grant [KMU-TC109A01-1]
FX This work was supported by the Research Center for Environmental
   Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan from The
   Featured Areas Research Center Program within the framework of the
   Higher Education Sprout Project by the Ministry of Education (MOE) in
   Taiwan and by Kaohsiung Medical University Research Center Grant
   (KMU-TC109A01-1). The funders had no role in study design, data
   collection and analysis, decision to publish, or preparation of the
   manuscript.
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NR 49
TC 0
Z9 0
U1 2
U2 2
PU PEERJ INC
PI LONDON
PA 341-345 OLD ST, THIRD FLR, LONDON, EC1V 9LL, ENGLAND
SN 2167-8359
J9 PEERJ
JI PeerJ
PD DEC 11
PY 2024
VL 12
AR e18639
DI 10.7717/peerj.18639
PG 17
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA U8J9P
UT WOS:001414200700003
PM 39677960
OA gold
DA 2025-06-11
ER

PT J
AU Coker, SJ
   Berry, MJ
   Vissers, MCM
   Dyson, RM
AF Coker, Sharna J.
   Berry, Mary J.
   Vissers, Margreet C. M.
   Dyson, Rebecca M.
TI Maternal Vitamin C Intake during Pregnancy Influences Long-Term
   Offspring Growth with Timing- and Sex-Specific Effects in Guinea Pigs
SO NUTRIENTS
LA English
DT Article
DE vitamin C (ascorbate; ascorbic acid); pregnancy; maternal diet; foetal
   programming; foetal growth; postnatal growth; metabolic function; guinea
   pig
ID PITUITARY-ADRENAL AXIS; CATCH-UP GROWTH; PRENATAL EXPOSURE;
   GLUCOSE-METABOLISM; SOMATOTROPIC AXIS; DNA DEMETHYLATION;
   POSTNATAL-GROWTH; OXIDATIVE STRESS; BIRTH-WEIGHT; FACTOR-I
AB Our previous work in guinea pigs revealed that low vitamin C intake during preconception and pregnancy adversely affects fertility, pregnancy outcomes, and foetal and neonatal growth in a sex-dependent manner. To investigate the long-term impact on offspring, we monitored their growth from birth to adolescence (four months), recorded organ weights at childhood equivalence (28 days) and adolescence, and assessed physiological parameters like oral glucose tolerance and basal cortisol concentrations. We also investigated the effects of the timing of maternal vitamin C restriction (early vs. late gestation) on pregnancy outcomes and the health consequences for offspring. Dunkin Hartley guinea pigs were fed an optimal (900 mg/kg feed) or low (100 mg/kg feed) vitamin C diet ad libitum during preconception. Pregnant dams were then randomised into four feeding regimens: consistently optimal, consistently low, low during early pregnancy, or low during late pregnancy. We found that low maternal vitamin C intake during early pregnancy accelerated foetal and neonatal growth in female offspring and altered glucose homeostasis in the offspring of both sexes at an age equivalent to early childhood. Conversely, low maternal vitamin C intake during late pregnancy resulted in foetal growth restriction and reduced weight gain in male offspring throughout their lifespan. We conclude that altered vitamin C during development has long-lasting, sex-specific consequences for offspring and that the timing of vitamin C depletion is also critical, with low levels during early development being associated with the development of a metabolic syndrome-related phenotype, while later deprivation appears to be linked to a growth-faltering phenotype.
C1 [Coker, Sharna J.; Berry, Mary J.; Dyson, Rebecca M.] Univ Otago, Dept Paediat & Child Hlth, Perinatal & Dev Physiol Grp, Wellington 6242, New Zealand.
   [Vissers, Margreet C. M.] Univ Otago, Matai Haora Ctr Redox Biol & Med, Dept Pathol & Biomed Sci, Christchurch 8140, New Zealand.
C3 University of Otago; University of Otago
RP Coker, SJ (corresponding author), Univ Otago, Dept Paediat & Child Hlth, Perinatal & Dev Physiol Grp, Wellington 6242, New Zealand.
EM sharna.coker@postgrad.otago.ac.nz; max.berry@otago.ac.nz;
   margreet.vissers@otago.ac.nz; becs.dyson@otago.ac.nz
RI Vissers, Margreet/T-4159-2017
OI Dyson, Rebecca/0000-0003-2319-6897; Vissers,
   Margreet/0000-0003-4261-0854; Berry, Mary/0000-0001-9798-6790
FU Royal Society Te Apamacr;rangi
FX The authors wish to acknowledge Robin Willink for his assistance with
   statistical advice and Helen Johnston, Heather Barnes, Nikki Galpin,
   Alice Freeman, Dylan Fromentin, and Ryan Sixtus for their assistance
   with the animal work.
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NR 93
TC 0
Z9 0
U1 3
U2 8
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD FEB
PY 2024
VL 16
IS 3
AR 369
DI 10.3390/nu16030369
PG 22
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA HS2P2
UT WOS:001161432300001
PM 38337653
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Beau, A
   Benoit, B
   Le Barz, M
   Meugnier, E
   Penhoat, A
   Calzada, C
   Pinteur, C
   Loizon, E
   Chanon, S
   Vieille-Marchiset, A
   Sauvinet, V
   Godet, M
   Laugerette, F
   Holowacz, S
   Jacouton, E
   Michalski, MC
   Vidal, H
AF Beau, Alice
   Benoit, Berengere
   Le Barz, Melanie
   Meugnier, Emmanuelle
   Penhoat, Armelle
   Calzada, Catherine
   Pinteur, Claudie
   Loizon, Emmanuelle
   Chanon, Stephanie
   Vieille-Marchiset, Aurelie
   Sauvinet, Valerie
   Godet, Murielle
   Laugerette, Fabienne
   Holowacz, Sophie
   Jacouton, Elsa
   Michalski, Marie-Caroline
   Vidal, Hubert
TI Inhibition of intestinal FXR activity as a possible mechanism for the
   beneficial effects of a probiotic mix supplementation on lipid
   metabolism alterations and weight gain in mice fed a high fat diet
SO GUT MICROBES
LA English
DT Article
DE Metabolic syndrome; high-fat diet; bifidobacterium animalis;
   lactobacillus gasseri; gut microbiota; bile acids; intestinal FXR
   signaling; lipid metabolism
ID OBESITY; MICROBIOTA; AXIS; SECRETION; PROTEIN
AB Supplementation with probiotics has emerged as a promising therapeutic tool to manage metabolic diseases. We investigated the effects of a mix of Bifidobacterium animalis subsp. lactis LA804 and Lactobacillus gasseri LA806 on high-fat (HF) diet -induced metabolic disease in mice. Supplementation with the probiotic mix in HF diet-fed mice (HF-Pr2) reduced weight and fat mass gains, decreased hepatic lipid accumulation, and lowered plasma triglyceride peak during an oral lipid tolerance test. At the molecular level, the probiotic mix protected against HF-induced rise in mRNA levels of genes related to lipid uptake, metabolism, and storage in the liver and white adipose tissues, and strongly decreased mRNA levels of genes related to inflammation in the white adipose tissue and to oxidative stress in the liver. Regarding intestinal homeostasis, the probiotic mix did not prevent HF-induced gut permeability but slightly modified microbiota composition without correcting the dysbiosis induced by the HF diet. Probiotic supplementation also modified the cecal bile acid (BA) profile, leading to an increase in the Farnesoid-X-Receptor (FXR) antagonist/agonist ratio between BA species. In agreement, HF-Pr2 mice exhibited a strong inhibition of FXR signaling pathway in the ileum, which was associated with lipid metabolism protection. This is consistent with recent reports proposing that inhibition of intestinal FXR activity could be a potent mechanism to overcome metabolic disorders. Altogether, our results demonstrate that the probiotic mix evaluated, when administered preventively to HF diet-fed mice could limit obesity and associated lipid metabolism disorders, likely through the inhibition of FXR signaling in the intestinal tract.
C1 [Beau, Alice; Benoit, Berengere; Le Barz, Melanie; Meugnier, Emmanuelle; Penhoat, Armelle; Calzada, Catherine; Pinteur, Claudie; Loizon, Emmanuelle; Chanon, Stephanie; Vieille-Marchiset, Aurelie; Godet, Murielle; Laugerette, Fabienne; Michalski, Marie-Caroline; Vidal, Hubert] Univ Claude Bernard Lyon1, Lab CarMeN, INSERM, U 1060,INRAe,U 1397, Pierre Benite, France.
   [Sauvinet, Valerie; Michalski, Marie-Caroline; Vidal, Hubert] Univ Claude Bernard Lyon 1, Ctr Rech Nutr Humaine Rhone Alpes, INSERM, INRAe,Hosp Civils Lyon, Pierre Benite, France.
   [Holowacz, Sophie; Jacouton, Elsa] PiLeJe Lab, Res & Dev Dept, Paris, France.
   [Vidal, Hubert] Univ Claude Bernard Lyon 1, Lab CarMeN, INSERM U1060, INRAe U 1397, 165 Chemin Grand Revoyet, F-69310 Pierre Benite, France.
C3 Institut National de la Sante et de la Recherche Medicale (Inserm);
   INRAE; Universite Claude Bernard Lyon 1; Universite Claude Bernard Lyon
   1; Institut National de la Sante et de la Recherche Medicale (Inserm);
   INRAE; CHU Lyon; Institut National de la Sante et de la Recherche
   Medicale (Inserm); INRAE; Universite Claude Bernard Lyon 1
RP Vidal, H (corresponding author), Univ Claude Bernard Lyon 1, Lab CarMeN, INSERM U1060, INRAe U 1397, 165 Chemin Grand Revoyet, F-69310 Pierre Benite, France.
EM hubert.vidal@univ-lyon1.fr
RI PENHOAT, ARMELLE/GMX-2754-2022; VIDAL, Hubert/M-6674-2017
OI PENHOAT, ARMELLE/0000-0003-3181-9564; VIDAL, Hubert/0000-0002-9467-0317;
   Le Barz, Melanie/0000-0002-2112-5254
FU Pileje Laboratoire; INSERM
FX This work was supported by the Pileje Laboratoire and by a research
   grant from INSERM (Transversal Program on Microbiota 2019-2022).
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NR 66
TC 10
Z9 10
U1 5
U2 38
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1949-0976
EI 1949-0984
J9 GUT MICROBES
JI Gut Microbes
PD DEC 18
PY 2023
VL 15
IS 2
AR 2281015
DI 10.1080/19490976.2023.2281015
PG 21
WC Gastroenterology & Hepatology; Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Microbiology
GA Y5MB0
UT WOS:001105685200001
PM 37985749
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Rodrigues, MO
   Moraes, AB
   de Paula, MP
   Pereira, VA
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AF Rodrigues, M. O.
   Moraes, A. B.
   de Paula, M. P.
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   Leao, A. T. T.
   Vieira Neto, L.
TI Adrenal incidentaloma as a novel independent predictive factor for
   periodontitis
SO JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
LA English
DT Article
DE Adrenal incidentaloma; Periodontal disease; Periodontitis;
   Non-functioning adrenal incidentaloma; Autonomous cortisol secretion
ID CARDIOVASCULAR EVENTS; METABOLIC SYNDROME; ASSOCIATION; MANAGEMENT;
   DISEASES; SMOKING; STRESS; HEALTH; RISK
AB Purpose There are no data regarding periodontal derangements in patients with adrenal incidentalomas (AI). We assessed the frequency and severity of periodontitis in patients with AI [non-functioning adrenal incidentaloma (NFAI) and possible autonomous cortisol secretion (ACS)] and compared with individuals with normal adrenal. Methods A cross-sectional study evaluated thirty-five individuals with AI and 26 controls. NFAI and possible ACS diagnosis was based on the current guidelines: NFAI [cortisol levels after 1 mg dexamethasone suppression test (1 mg-DST) <= 1.8 mu g/dL (<= 50 nmol/L)]; possible ACS [cortisol levels after 1 mg-DST 1.9-5.0 mu g/dL (51-138 nmol/L)]. Sociodemographic data were collected, and a full-mouth periodontal evaluation was performed. Results There was no significant difference between groups regarding age, sex, income, ethnicity, education level, smoking, body mass index, dysglycemia, and arterial hypertension. Patients with AI exhibited worse periodontal conditions than controls for the following periodontal clinical parameters: mean percentage of probing pocket depth (PPD) and clinical attachment level (CAL) >= 5 mm (p < 0.001 and p = 0.006, respectively). Patients with NFAI and possible ACS showed higher gingival bleeding index (p = 0.014), bleeding on probing (p < 0.001), and CAL (p < 0.001) means compared to controls. The frequencies of periodontitis were 72.7% in patients with NFAI, 84.6% in possible ACS, and 30.8% in controls (p = 0.001). Periodontitis was more severe in patients with possible ACS than NFAI and controls. Patients with NFAI and possible ACS exhibited odds ratio for periodontitis of 4.9 (p = 0.016) and 8.6 (p = 0.02), respectively. Conclusion Patients with AI have higher frequency and severity of periodontitis than controls. The presence of AI was an independent predictive factor for periodontitis.
C1 [Rodrigues, M. O.; Pereira, V. A.; Leao, A. T. T.] Univ Fed Rio de Janeiro, Dent Sch, Div Periodont, Dept Dent Clin, Rio De Janeiro, Brazil.
   [Moraes, A. B.; de Paula, M. P.; Vieira Neto, L.] Univ Fed Rio de Janeiro, Clementino Fraga Filho Univ Hosp, Sch Med, Dept Internal Med, Prof Rodolpho Paulo Rocco St, BR-21941913 Rio De Janeiro, RJ, Brazil.
   [Moraes, A. B.; de Paula, M. P.; Vieira Neto, L.] Univ Fed Rio de Janeiro, Clementino Fraga Filho Univ Hosp, Sch Med, Endocrine Unit, Prof Rodolpho Paulo Rocco St, BR-21941913 Rio De Janeiro, RJ, Brazil.
C3 Universidade Federal do Rio de Janeiro; Universidade Federal do Rio de
   Janeiro; Universidade Federal do Rio de Janeiro
RP Neto, LV (corresponding author), Univ Fed Rio de Janeiro, Clementino Fraga Filho Univ Hosp, Sch Med, Dept Internal Med, Prof Rodolpho Paulo Rocco St, BR-21941913 Rio De Janeiro, RJ, Brazil.; Neto, LV (corresponding author), Univ Fed Rio de Janeiro, Clementino Fraga Filho Univ Hosp, Sch Med, Endocrine Unit, Prof Rodolpho Paulo Rocco St, BR-21941913 Rio De Janeiro, RJ, Brazil.
EM netolv@gmail.com
RI Filho, Valfrido/B-8312-2012
OI Vieira Neto, Leonardo/0000-0002-1595-3985; Barbosa Moraes,
   Aline/0000-0001-7533-7458; Rodrigues, Monique/0000-0002-9283-9406; Thome
   Leao, Anna Thereza/0000-0001-5249-6616
FU Research Support Foundation of the State of Rio de Janeiro-FAPERJ
   [E-26/202.700/2019-244480]; Brazilian National Council for Scientific
   and Technological Development-CNPq [312413/2019-0]
FX This work was supported by the Research Support Foundation of the State
   of Rio de Janeiro-FAPERJ (grant number E-26/202.700/2019-244480); and
   Brazilian National Council for Scientific and Technological
   Development-CNPq (grant number 312413/2019-0).
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NR 38
TC 5
Z9 5
U1 0
U2 2
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0391-4097
EI 1720-8386
J9 J ENDOCRINOL INVEST
JI J. Endocrinol. Invest.
PD NOV
PY 2021
VL 44
IS 11
BP 2455
EP 2463
DI 10.1007/s40618-021-01557-w
EA MAR 2021
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA WD9NH
UT WOS:000635496700001
PM 33788166
DA 2025-06-11
ER

PT J
AU Hernández-Collazo, AA
   Pérez-Méndez, O
   López-Olmos, V
   Delgado-Rizo, V
   Muñoz-Valle, JF
   Martínez-López, E
   Villanueva-Quintero, DG
   Domínguez-Díaz, C
   Fafutis-Morris, M
   Alvarado-Navarro, A
AF Hernandez-Collazo, A. A.
   Perez-Mendez, Oscar
   Lopez-Olmos, Victoria
   Delgado-Rizo, V.
   Munoz-Valle, J. F.
   Martinez-Lopez, Erika
   Villanueva-Quintero, D. G.
   Dominguez-Diaz, Carolina
   Fafutis-Morris, Mary
   Alvarado-Navarro, Anabell
TI Association between rs662 (A &gt; G) and rs854560 (A &gt; T)
   polymorphisms in PON1 gene and the susceptibility for psoriasis
   in mestizo population of Western Mexico
SO MOLECULAR BIOLOGY REPORTS
LA English
DT Article
DE Psoriasis; PON1; Paraoxonase; Arylesterase; HDL-C; Polymorphisms
ID LOW-DENSITY-LIPOPROTEIN; CORONARY-HEART-DISEASE; CARDIOVASCULAR-DISEASE;
   PARAOXONASE 1; SERUM PARAOXONASE; ARYLESTERASE ACTIVITIES; METABOLIC
   SYNDROME; ENZYME-ACTIVITIES; OXIDATIVE STRESS; RISK-FACTORS
AB Psoriasis is a chronic, autoimmune skin disease. In psoriasis, PON1 activity is diminished and peroxidation biomarkers are elevated. The most studied PON1 polymorphisms are rs662 (A > G) and rs854560 (A > T), which have been associated with the antioxidant activity of PON1, risk of cardiovascular diseases and psoriasis development. The aim of this study, was to determine the association of rs662 (A > G) and rs854560 (A > T) PON1 polymorphisms with psoriasis susceptibility in Western Mexico population. In this case-control study, we included 104 psoriasis patients and 124 control subjects. The genotyping of polymorphisms rs662 (A > G) and rs854560 (A > T) of PON1 was carried out by PCR-RFLPs. The lipid profiles were quantified by enzymatic colorimetric method, and PON1 activity was determined by spectrophotometry. The lipid profile levels, except HDL-C and atherogenic index, were higher in patients vs. controls. Patients presented lower paraoxonase and arylesterase activity. The G allele of rs662 (A > G) is associated with risk for psoriasis, while the T allele of rs854560 (A > T) is associated with low susceptibility to psoriasis. The AG haplotype was more frequent within the patient group (p < 0.05). The AA and AG genotypes of rs662 (A > G) and TT and AA genotypes of rs854560 (A > T) are associated with lower PONase and ARE activity in patients vs. controls. Patients with the G allele of rs662 (G > A) and T alleles of rs854560 (A > T) show significant differences in the lipid levels in comparison to controls. These results suggest that carriers of G allele of rs662 (A > G) present a greater susceptibility to psoriasis.
C1 [Hernandez-Collazo, A. A.] Univ Autonoma Aguascalientes, Ctr Ciencias Salud, Av Univ 940,Modulo101, Aguascalientes 20131, Aguascalientes, Mexico.
   [Perez-Mendez, Oscar; Lopez-Olmos, Victoria] Inst Nacl Cardiol Ignacio Chavez, Dept Mol Biol, Juan Badiano 1,Secc 16, Mexico City 14080, DF, Mexico.
   [Perez-Mendez, Oscar] Tecnol Monterrey, Sch Sci & Engn, Campus Ciudad Mexico,Calle Puente 222, Mexico City 14380, DF, Mexico.
   [Delgado-Rizo, V.] Univ Guadalajara, Ctr Univ Ciencias Salud, Dept Fisiol, Lab Inmunol, Sierra Mojada 950, Guadalajara 44340, Jal, Mexico.
   [Munoz-Valle, J. F.] Univ Guadalajara, Inst Invest Ciencias Biomed, Sierra Mojada 950, Guadalajara 44340, Jal, Mexico.
   [Martinez-Lopez, Erika] Univ Guadalajara, Ctr Univ Ciencias Salud, Dept Biol Mol & Genom, Inst Nutrigenet & Nutrigenom, Sierra Mojada 950, Guadalajara 44340, Jal, Spain.
   [Villanueva-Quintero, D. G.] Ctr Atenc Enfermedades Inflamatorias Jose Maria V, Col Lomas Guevara 2750, Guadalajara 44657, Jal, Mexico.
   [Dominguez-Diaz, Carolina; Fafutis-Morris, Mary; Alvarado-Navarro, Anabell] Univ Guadalajara, Ctr Univ Ciencias Salud, Dept Fisiol, Ctr Invest Inmunol & Dermatol, Sierra Mojada 950, Guadalajara 44340, Jalisco, Mexico.
C3 Universidad Autonoma de Aguascalientes; National Institute of Cardiology
   - Mexico; Tecnologico de Monterrey; Universidad de Guadalajara;
   Universidad de Guadalajara; Universidad de Guadalajara
RP Alvarado-Navarro, A (corresponding author), Univ Guadalajara, Ctr Univ Ciencias Salud, Dept Fisiol, Ctr Invest Inmunol & Dermatol, Sierra Mojada 950, Guadalajara 44340, Jalisco, Mexico.
EM vidal.delgado@academicos.udg.mx; drjosefranciscomv@cucs.udg.mx;
   mary.fafutis@academicos.udg.mx; anabell.alvarado@academicos.udg.mx
RI ALVARADO, ANABELL/HJY-0021-2023; Pérez-Méndez, Oscar/AAJ-8451-2020;
   Fafutis-Morris, Mary/AGG-1618-2022; Martínez-López, Erika/Y-6384-2019
OI Hernandez Collazo, Adameck Abraham/0000-0002-8248-7208; Perez-Mendez,
   Oscar/0000-0002-6977-1829; Alvarado Navarro,
   Anabell/0000-0002-5719-1712; MARTINEZ-LOPEZ, ERIKA/0000-0003-2005-9512;
   LOPEZ-OLMOS, VICTORIA/0000-0002-0563-2168; Dominguez Diaz,
   Carolina/0000-0002-6721-5300
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NR 56
TC 8
Z9 8
U1 0
U2 4
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0301-4851
EI 1573-4978
J9 MOL BIOL REP
JI Mol. Biol. Rep.
PD JAN
PY 2021
VL 48
IS 1
BP 183
EP 194
DI 10.1007/s11033-020-06031-z
EA DEC 2020
PG 12
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA QH6JS
UT WOS:000599046200001
PM 33284416
DA 2025-06-11
ER

PT J
AU Cartmel, B
   Anderson, C
   Irwin, ML
   Harrigan, M
   Sanft, T
   Li, FY
   Gellermann, W
   Ermakov, IV
   Ferrucci, LM
AF Cartmel, Brenda
   Anderson, Chelsea
   Irwin, Melinda L.
   Harrigan, Maura
   Sanft, Tara
   Li, Fangyong
   Gellermann, Werner
   Ermakov, Igor, V
   Ferrucci, Leah M.
TI Skin carotenoids are inversely associated with adiposity in breast
   cancer survivors
SO NUTRITION RESEARCH
LA English
DT Article
ID RESONANCE RAMAN-SPECTROSCOPY; PLASMA CAROTENOIDS; METABOLIC SYNDROME;
   SERUM CAROTENOIDS; OXIDATIVE STRESS; UNITED-STATES; LIFE-STYLE;
   VITAMIN-C; RISK; INFLAMMATION
AB Carotenoids are antioxidants which may mitigate some of the adverse effects of obesity, a condition associated with poor outcomes in breast cancer patients. We hypothesized that baseline skin carotenoids would be inversely associated with adiposity in breast cancer survivors and would increase with weight loss. Skin carotenoid score (SCS) was assessed by resonance Raman spectroscopy in breast cancer survivors (body mass index >= 25 kg/m(2)) enrolled in a 6-month randomized controlled weight loss trial (n = 47). Measurements included total body fat using dual-energy X-ray absorptiometry, height, weight, waist and hip circumference, dietary intake, and serum biomarkers. Associations between SCS, adiposity measures, and serum biomarkers were assessed at baseline, as was the change in SCS from baseline to 6 months, in the intervention and usual care groups. At baseline, SCS was inversely correlated with all adiposity measures (P <= .05). In multivariate analyses, baseline percent body fat had the strongest association with baseline SCS (partial R-2= 0.20). Baseline SCS was significantly inversely associated with log C-reactive protein levels (regression coefficient beta +/- SE: -0.051 +/- 0.019; P = .011) and log leptin beta +/- SE: -0.019 +/- 0.009; P = .046), but the associations were no longer significant after adjustment for adiposity. Over the 6-month study, the intervention group had a 17.6% increase in SCS compared to a 1.5% decrease in the usual care group (P = .28). In our study of overweight and obese breast cancer survivors, dual-energy X-ray absorptiometry-measured body fat explained a large portion of the variation in skin carotenoids at baseline, suggesting a stronger association than that previously seen in studies using less accurate measures of adiposity. (C) 2020 Elsevier Inc. All rights reserved.
C1 [Cartmel, Brenda; Anderson, Chelsea; Irwin, Melinda L.; Harrigan, Maura; Li, Fangyong; Ferrucci, Leah M.] Yale Sch Publ Hlth, 60 Coll St, New Haven, CT 06511 USA.
   [Cartmel, Brenda; Irwin, Melinda L.; Sanft, Tara; Ferrucci, Leah M.] Yale Canc Ctr, POB 208028, New Haven, CT 06519 USA.
   [Sanft, Tara] Yale Sch Med, 333 Cedar St, New Haven, CT 06511 USA.
   [Gellermann, Werner; Ermakov, Igor, V] Longev Link Corp, 391 Chipeta Way,Suite E, Salt Lake City, UT 84108 USA.
   [Anderson, Chelsea] Amer Canc Soc, 250 Williams St NW, Atlanta, GA 30303 USA.
C3 Yale University; Yale University; Yale New Haven Hospital; Yale
   University; American Cancer Society
RP Cartmel, B (corresponding author), Yale Sch Publ Hlth, 60 Coll St, New Haven, CT 06511 USA.
EM brenda.cartmel@yale.edu; chelsea.anderson@cancer.org;
   melinda.irwin@yale.edu; maura.harrigan@yale.edu; tara.sanft@yale.edu;
   fangyong.li@yale.edu; werner@longevitylinkcorporation.com;
   igor@longevitylinkcorporation.com; leah.ferrucci@yale.edu
FU American Institute for Cancer Research; Breast Cancer Research
   Foundation; Yale Cancer Center Support Grant [P30 CA016359]; National
   Center for Advancing Translational Science, a component of the National
   Institutes of Health [UL1 TR000142]
FX The authors would like to thank Rajni Mehta and the Rapid Case
   Ascertainment of Yale Cancer Center, as well as the Smilow Cancer
   Hospital at Yale-New Haven and all the clinicians who consented or
   referred their patients to our study. Most importantly, we are indebted
   to the participants for their dedication to the LEAN study. The authors
   do not have any potential conflicts of interest. Of note, WG has a
   patent (US patent 8,260,402) issued which is broadly relevant to the
   work. The study was supported by American Institute for Cancer Research
   and in part by a grant from the Breast Cancer Research Foundation. It is
   also supported in part by the Yale Cancer Center Support Grant P30
   CA016359 and the Clinical and Translational Science Award Grant Number
   UL1 TR000142 from the National Center for Advancing Translational
   Science, a component of the National Institutes of Health. The sponsors
   had no involvement in study design; in the collection, analysis, and
   interpretation of data; in the writing of the report; and in the
   decision to submit the article for publication.
CR Andò S, 2019, CANCERS, V11, DOI 10.3390/cancers11010062
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NR 46
TC 3
Z9 3
U1 0
U2 7
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0271-5317
EI 1879-0739
J9 NUTR RES
JI Nutr. Res.
PD JUL
PY 2020
VL 79
BP 77
EP 86
DI 10.1016/j.nutres.2020.05.012
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA MU5FD
UT WOS:000555698200008
PM 32650223
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Samadi, A
   Isikhan, SY
   Tinkov, AA
   Lay, I
   Dosa, MD
   Skalny, AV
   Skalnaya, MG
   Chirumbolo, S
   Bjorklund, G
AF Samadi, Afshin
   Isikhan, Selen Yilmaz
   Tinkov, Alexey A.
   Lay, Incilay
   Dosa, Monica Daniela
   Skalny, Anatoly, V
   Skalnaya, Margarita G.
   Chirumbolo, Salvatore
   Bjorklund, Geir
TI Zinc, copper, and oxysterol levels in patients with type 1 and type 2
   diabetes mellitus
SO CLINICAL NUTRITION
LA English
DT Article
DE Diabetes mellitus; Zinc; Copper; Oxysterol
ID SERUM TRACE-ELEMENTS; POSTMENOPAUSAL WOMEN; LIPID-PEROXIDATION;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; PLASMA OXYSTEROLS; OXIDATIVE
   STRESS; DISEASE; IRON; SUPPLEMENTATION
AB Background: The present study has the objective to assess the zinc (Zn), copper (Cu), and oxysterols plasma levels in type 1 (DM1) (n = 26) and type 2 (DM2) (n = 80) diabetes patients, as compared to healthy controls (n = 71), in order to testify whether metal levels may have a significant impact on the association between oxysterols and diabetes.
   Methods: Plasma trace elements and plasma oxysterols were assessed using atomic absorption spectrometry and LC-MS/MS, respectively. Lifestyle, smoking status, alcohol intake, and drug usage, as well as microvascular complications, were also monitored and reported.
   Results: The obtained data demonstrated that both DM1 and DM2 patients were characterized by significantly elevated HbA1c, FBG, TC, LDL-C, VLDL-C, and TG levels as compared to controls. Plasma Zn levels and Zn/Cu ratio in DM1 and DM2 patients were about 3- and 2-fold lower than controls. No significant differences in plasma Cu levels were reported. The 7-ketocholesterol (7-kchol) levels in DM1 and DM2 patients exceeded these values in healthy individuals by 2.5 and 5-fold, respectively. Similarly, cholestan-3 beta, 5 alpha, 6 beta-triol (chol-triol) levels were more than 3- and 6-fold higher when compared to the respective values in non-diabetic controls. In regression models decreased plasma Zn and elevated oxysterol levels were significantly associated with HbAlc and fasting plasma glucose levels, after adjustment for anthropometric and clinical variables, as well as routine biochemical markers.
   Conclusions: Plasma Zn concentration is inversely associated with both 7-kchol and chol-triol levels. Assessment of Zn and oxysterol levels may be used both for risk assessment and as targets for the treatment of diabetes mellitus. (C) 2019 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.
C1 [Samadi, Afshin; Lay, Incilay] Hacettepe Univ, Fac Med, Dept Med Biochem, Ankara, Turkey.
   [Isikhan, Selen Yilmaz] Hacettepe Univ, Fac Med, Dept Biostat, Ankara, Turkey.
   [Isikhan, Selen Yilmaz] Hacettepe Univ, Vocat Sch Social Sci, Ankara, Turkey.
   [Tinkov, Alexey A.] Yaroslavl State Univ, Yaroslavl, Russia.
   [Tinkov, Alexey A.; Skalny, Anatoly, V; Skalnaya, Margarita G.] Peoples Friendship Univ Russia, RUDN Univ, Moscow, Russia.
   [Tinkov, Alexey A.; Skalny, Anatoly, V; Skalnaya, Margarita G.] IM Sechenov First Moscow State Med Univ, Sechenov Univ, Moscow, Russia.
   [Lay, Incilay] Hacettepe Univ Hosp, Clin Pathol Lab, Ankara, Turkey.
   [Dosa, Monica Daniela] Ovidius Univ, Fac Med, Dept Pharmacol, Constanta, Romania.
   [Skalny, Anatoly, V] Russian Acad Sci, Fed Res Ctr Biol Syst & Agrotechnol, Orenburg, Russia.
   [Chirumbolo, Salvatore] Univ Verona, Dept Neurosci Biomed & Movement Sci, Verona, Italy.
   [Chirumbolo, Salvatore] CONEM Sci Secretary, Verona, Italy.
   [Bjorklund, Geir] Council Nutr & Environm Med CONEM, Toften 24, N-8610 Mo I Rana, Norway.
C3 Hacettepe University; Hacettepe University; Hacettepe University;
   Yaroslavl State University; Peoples Friendship University of Russia;
   Sechenov First Moscow State Medical University; Hacettepe University;
   Ovidius University; Russian Academy of Sciences; Federal Research Centre
   of Biological Systems & Agro-technologies of the Russian Academy of
   Sciences; University of Verona
RP Bjorklund, G (corresponding author), Council Nutr & Environm Med CONEM, Toften 24, N-8610 Mo I Rana, Norway.
EM bjorklund@conem.org
RI Chirumbolo, Salvatore/AGF-1981-2022; LAY, INCILAY/I-8315-2013; Dosa,
   Monica/S-4656-2019; Tinkov, Alexey/H-5842-2016; Skalny,
   Anatoly/J-3953-2019; Samadi, Afshin/F-8597-2018; Yilmaz,
   Selen/J-2351-2013; Bjorklund, Geir/B-7319-2014; Chirumbolo,
   Salvatore/L-6865-2016
OI Samadi, Afshin/0000-0001-7702-2273; Yilmaz, Selen/0000-0002-3725-2987;
   Bjorklund, Geir/0000-0003-2632-3935; Chirumbolo,
   Salvatore/0000-0003-1789-8307
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NR 69
TC 35
Z9 37
U1 1
U2 12
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0261-5614
EI 1532-1983
J9 CLIN NUTR
JI Clin. Nutr.
PD JUN
PY 2020
VL 39
IS 6
BP 1849
EP 1856
DI 10.1016/j.clnu.2019.07.026
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA LT2RE
UT WOS:000536918600025
PM 31427180
DA 2025-06-11
ER

PT J
AU Zhao, L
   Cen, F
   Tian, F
   Li, MJ
   Zhang, Q
   Shen, HY
   Shen, XC
   Zhou, MM
   Du, J
AF Zhao, Le
   Cen, Fang
   Tian, Feng
   Li, Min-Jie
   Zhang, Qi
   Shen, Hong-Yi
   Shen, Xiang-Chun
   Zhou, Ming-Mei
   Du, Jun
TI Combination treatment with quercetin and resveratrol attenuates high fat
   diet-induced obesity and associated inflammation in rats via the
   AMPKα1/SIRT1 signaling pathway
SO EXPERIMENTAL AND THERAPEUTIC MEDICINE
LA English
DT Article
DE quercetin; resveratrol; high-fat diet; inflammation; 5 '-adenosine
   monophosphate-activated protein kinase catalytic subunit alpha-1;
   sirtuin 1
ID ADIPOSE-TISSUE INFLAMMATION; OXIDATIVE STRESS; METABOLIC SYNDROME;
   MACROPHAGE POLARIZATION; CARDIOVASCULAR-DISEASE; MITOCHONDRIAL-FUNCTION;
   ZUCKER RATS; MAST-CELLS; SIRT1; MICE
AB Diet-induced obesity is associated with systemic inflammation, which is considered to originate predominantly from the adipose tissue. Quercetin and resveratrol are two dietary polyphenols that exhibit anti-inflammatory properties and anti-insulin resistance when administered in isolation or combination (CQR). It remains unknown whether CQR reduces high fat diet (HFD)-induced obesity and inflammation in rats. In the current study, 46 male Wistar rats were divided into two groups, one of which was fed a normal diet (ND, 5.4% fat, w/w) and one of which was fed a HFD (45% fat, w/w) for 3 weeks. Following removal of the 12 most obesity-resistant rats from the HFD group, the remaining rats were divided into two sub-groups: A HFD group and a HFD+ CQR group (administered 120 mg/kg/day resveratrol and 240 mg/kg/day quercetin). The results revealed that the HFD+ CQR group had significantly lower body weights at 11 weeks compared with the HFD group and had significantly reduced visceral adipose tissue weights and adipocyte sizes. Serum lipid profiles were also significantly ameliorated in the HFD+ CQR group. CQR attenuated the expression of systemic proinflammatory adipokines, including leptin, tumor necrosis factor-alpha, monocyte chemoattractant protein-1 and interleukin-6. It also reduced the recruitment of mast cells to the epididyotic adipose tissue (EAT). Furthermore, CQR reversed the HFD-induced suppression of 5'-adenosine monophosphate-activated protein kinase alpha 1 (AMPK alpha 1) phosphorylation and sirtuin 1 (SIRT1) expression in EAT. In conclusion, CQR may suppress obesity and associated inflammation via the AMPK alpha 1/SIRT1 signaling pathway in rats fed a HFD.
C1 [Zhao, Le; Cen, Fang; Zhou, Ming-Mei] Shanghai Univ Tradit Chinese Med, Interdisciplinary Sci Res Inst, Ctr Chinese Med Therapy & Syst Biol, 1200 Cailun Rd, Shanghai 201203, Peoples R China.
   [Tian, Feng; Li, Min-Jie; Zhang, Qi; Du, Jun] Nutrilite Hlth Inst, 720-6 Cailun Rd, Shanghai 201203, Peoples R China.
   [Shen, Hong-Yi] Shanghai Univ Tradit Chinese Med, Sch Publ Hlth, Res Ctr Hlth & Nutr, Shanghai 201203, Peoples R China.
   [Shen, Xiang-Chun] Guizhou Med Univ, Sch Pharmaceut Sci, High Educ Key Lab Guizhou Nat Med Pharmacol & Dru, Huaxi 550025, Guizhou, Peoples R China.
C3 Shanghai University of Traditional Chinese Medicine; Shanghai University
   of Traditional Chinese Medicine; Guizhou Medical University
RP Zhou, MM (corresponding author), Shanghai Univ Tradit Chinese Med, Interdisciplinary Sci Res Inst, Ctr Chinese Med Therapy & Syst Biol, 1200 Cailun Rd, Shanghai 201203, Peoples R China.; Du, J (corresponding author), Nutrilite Hlth Inst, 720-6 Cailun Rd, Shanghai 201203, Peoples R China.
EM zhoumm368@163.com; eric.du@amway.com
RI Du, Jun/GLT-4866-2022
FU Education Department of Guizhou Province [2014-31]; Scientific and
   Technologic Innovated Team of Guizhou Province [2015-4025]; High-level
   Innovation Talents [2015-4029]; Shanghai Municipal Education Commission;
   Amway (China) Research and Development Center Ltd., Co.
FX The present study was supported by the Education Department of Guizhou
   Province 1 (grant no. 2014-31), the Scientific and Technologic Innovated
   Team of Guizhou Province 2 (grant no. 2015-4025), the High-level
   Innovation Talents 3 (grant no. 2015-4029), the Teacher Development
   Project of Shanghai Municipal Education Commission and the Innovation
   Project of Amway (China) Research and Development Center Ltd., Co.
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NR 60
TC 54
Z9 61
U1 1
U2 27
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1792-0981
EI 1792-1015
J9 EXP THER MED
JI Exp. Ther. Med.
PD DEC
PY 2017
VL 14
IS 6
BP 5942
EP 5948
DI 10.3892/etm.2017.5331
PG 7
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA FP7LE
UT WOS:000417815000100
PM 29285143
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Tabrizi, R
   Akbari, M
   Moosazadeh, M
   Lankarani, KB
   Heydari, ST
   Kolahdooz, F
   Mohammadi, AA
   Shabani, A
   Badehnoosh, B
   Jamilian, M
   Assarian, A
   Asemi, Z
AF Tabrizi, Reza
   Akbari, Maryam
   Moosazadeh, Mahmood
   Lankarani, Kamran B.
   Heydari, Seyed Taghi
   Kolahdooz, Fariba
   Mohammadi, Ali Akbar
   Shabani, Azade
   Badehnoosh, Bita
   Jamilian, Mehri
   Assarian, Amin
   Asemi, Zatollah
TI The Effects of Selenium Supplementation on Glucose Metabolism and Lipid
   Profiles Among Patients with Metabolic Diseases: A Systematic Review and
   Meta-Analysis of Randomized Controlled Trials
SO HORMONE AND METABOLIC RESEARCH
LA English
DT Article
DE selenium; glucose homeostasis; lipid profiles; meta-analysis
ID POLYCYSTIC-OVARY-SYNDROME; TYPE-2 DIABETES-MELLITUS; SERUM HS-CRP;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; PROSTATE-CANCER; PLASMA SELENIUM;
   DOUBLE-BLIND; DASH DIET; VITAMIN-E
AB This systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted to summarize the effect of selenium administration on glucose metabolism and lipid profiles among patients with diseases related to metabolic syndrome (MetS). We searched the following databases up to May 2017: MEDLINE, EMBASE, Web of Science, and Cochrane Central Register of Controlled Trials. The relevant data were extracted and assessed for quality of the studies according to the Cochrane risk of bias tool. Data were pooled using the inverse variance method and expressed as standardized mean difference (MDs) with 95% confidence intervals (95% CI). Five studies were included in the meta-analyses. The results showed that selenium supplementation significantly reduced insulin levels (SMD -0.42; 95% CI, -0.83 to -0.01) and increased quantitative insulin sensitivity check index (QUICKI) (SMD 0.83; 95% CI, 0.58 to 1.09). Selenium supplementation had no beneficial effects on other glucose homeostasis parameters, such as fasting plasma glucose (FPG) (SMD -0.29; 95% CI, -0.73 to 0.15), homeostasis model assessment of insulin resistance (HOMA-IR) (SMD -0.80; 95% CI, -1.58 to -0.03), and lipid profiles, such as triglycerides (SMD -0.42; 95% CI, -0.83 to -0.01), VLDL- (SMD -0.42; 95% CI, -0.83 to -0.01), total- (SMD -0.42; 95% CI, -0.83 to -0.01), LDL- (SMD 0.02; 95% CI, -0.20 to 0.24), and HDL-cholesterol (SMD 0.16; 95% CI, -0.06 to -0.38). Overall, this meta-analysis showed that selenium administration may lead to an improvement in insulin and QUICKI, but did not affect FPG, HOMA-IR, and lipid profiles.
C1 [Tabrizi, Reza; Akbari, Maryam] Shiraz Univ Med Sci, Inst Hlth, Ctr Hlth Policy Res, Student Res Comm, Shiraz, Iran.
   [Moosazadeh, Mahmood] Mazandaran Univ Med Sci, Fac Hlth, Hlth Sci Res Ctr, Sari, Iran.
   [Lankarani, Kamran B.; Heydari, Seyed Taghi] Shiraz Univ Med Sci, Ctr Hlth Policy Res, Shiraz, Iran.
   [Kolahdooz, Fariba] Univ Alberta, Dept Med, Indigenous & Global Hlth Res, Edmonton, AB, Canada.
   [Mohammadi, Ali Akbar] Petr Ind Hlth Org, Tehran, Iran.
   [Shabani, Azade] Shahid Beheshti Univ Med Sci, Sch Med, Dept Gynecol & Obstet, Tehran, Iran.
   [Badehnoosh, Bita] Alborz Univ Med Sci, Sch Med, Dept Gynecol & Obstet, Karaj, Iran.
   [Jamilian, Mehri] Arak Univ Med Sci, Endocrinol & Metab Res Ctr, Arak, Iran.
   [Assarian, Amin] Univ Tehran Med Sci, Sch Pharm, Dept Pharmaceut, Tehran, Iran.
   [Asemi, Zatollah] Kashan Univ Med Sci, Res Ctr Biochem & Nutr Metab Dis, Kashan, Iran.
C3 Shiraz University of Medical Science; Mazandaran University of Medical
   Sciences; Shiraz University of Medical Science; University of Alberta;
   Shahid Beheshti University Medical Sciences; Alborz University of
   Medical Sciences; Tehran University of Medical Sciences
RP Asemi, Z (corresponding author), Kashan Univ Med Sci, Res Ctr Biochem & Nutr Metab Dis, Kashan, Iran.
EM asemi_r@yahoo.com
RI shabani, azadeh/AAA-6923-2022; badehnoosh, bita/O-4297-2017; Lankarani,
   Kamran/P-5336-2019; jamilian, mehri/F-7559-2016; Tabrizi,
   Reza/AAC-2486-2021; Akbari, Ali/G-6044-2016; asemi,
   zatollah/J-2677-2018; Heydari, Seyed/U-9403-2019; Akbari,
   Hamed/B-5923-2018; moosazadeh, mahmood/F-3730-2017; Heydari, Seyyed
   Taghi/T-3309-2017
OI moosazadeh, mahmood/0000-0002-5452-514X; Heydari, Mohammad
   Hossein/0000-0001-6764-4394; Heydari, Seyyed Taghi/0000-0001-7711-1137;
   tabrizi, reza/0000-0001-7634-3948
FU Vice-Chancellor for Research, SUMS, in Iran
FX The current study was founded by a grant from the Vice-Chancellor for
   Research, SUMS, in Iran.
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NR 42
TC 45
Z9 45
U1 2
U2 17
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0018-5043
EI 1439-4286
J9 HORM METAB RES
JI Horm. Metab. Res.
PD NOV
PY 2017
VL 49
IS 11
BP 826
EP 830
DI 10.1055/s-0043-119544
PG 5
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA FM7PT
UT WOS:000415273000003
PM 28992632
DA 2025-06-11
ER

PT J
AU Tanami, Y
   Jinzaki, M
   Kishi, S
   Matheson, M
   Vavere, AL
   Rochitte, CE
   Dewey, M
   Chen, MY
   Clouse, ME
   Cox, C
   Kuribayashi, S
   Lima, JAC
   Arbab-Zadeh, A
AF Tanami, Yutaka
   Jinzaki, Masahiro
   Kishi, Satoru
   Matheson, Matthew
   Vavere, Andrea L.
   Rochitte, Carlos E.
   Dewey, Marc
   Chen, Marcus Y.
   Clouse, Melvin E.
   Cox, Christopher
   Kuribayashi, Sachio
   Lima, Joao A. C.
   Arbab-Zadeh, Armin
TI Lack of Association Between Epicardial Fat Volume and Extent of Coronary
   Artery Calcification, Severity of Coronary Artery Disease, or Presence
   of Myocardial Perfusion Abnormalities in a Diverse, Symptomatic Patient
   Population Results From the CORE320 Multicenter Study
SO Circulation-Cardiovascular Imaging
LA English
DT Article
DE coronary artery disease; coronary stenosis; myocardial ischemia
ID MULTISLICE COMPUTED-TOMOGRAPHY; CARDIOVASCULAR RISK-FACTORS; VISCERAL
   ABDOMINAL FAT; ADIPOSE-TISSUE VOLUME; BODY-MASS INDEX; PERICARDIAL FAT;
   DIAGNOSTIC PERFORMANCE; METABOLIC SYNDROME; CT ANGIOGRAPHY;
   ATHEROSCLEROSIS
AB Background-Epicardial fat may play a role in the pathogenesis of coronary artery disease (CAD). We explored the relationship of epicardial fat volume (EFV) with the presence and severity of CAD or myocardial perfusion abnormalities in a diverse, symptomatic patient population.
   Methods and Results-Patients (n=380) with known or suspected CAD who underwent 320-detector row computed tomographic angiography, nuclear stress perfusion imaging, and clinically driven invasive coronary angiography for the CORE320 international study were included. EFV was defined as adipose tissue within the pericardial borders as assessed by computed tomography using semiautomatic software. We used linear and logistic regression models to assess the relationship of EFV with coronary calcium score, stenosis severity by quantitative coronary angiography, and myocardial perfusion abnormalities by single photon emission computed tomography (SPECT). Median EFV among patients (median age, 62.6 years) was 102 cm(3) (interquartile range: 53). A coronary calcium score of >= 1 was present in 83% of patients. Fifty-nine percent of patients had >= 1 coronary artery stenosis of >= 50% by quantitative coronary angiography, and 49% had abnormal myocardial perfusion results by SPECT. There were no significant associations between EFV and coronary artery calcium scanning, presence severity of >= 50% stenosis by quantitative coronary angiography, or abnormal myocardial perfusion by SPECT.
   Conclusions-In a diverse population of symptomatic patients referred for invasive coronary angiography, we did not find associations of EFV with the presence and severity of CAD or with myocardial perfusion abnormalities. The clinical significance of quantifying EFV remains uncertain but may relate to the pathophysiology of acute coronary events rather than the presence of atherosclerotic disease.
C1 [Tanami, Yutaka; Jinzaki, Masahiro; Kuribayashi, Sachio] Keio Univ, Dept Radiol, Tokyo, Japan.
   [Kishi, Satoru; Vavere, Andrea L.; Lima, Joao A. C.; Arbab-Zadeh, Armin] Johns Hopkins Univ, Dept Med Cardiol, Baltimore, MD 21287 USA.
   [Matheson, Matthew; Cox, Christopher] Johns Hopkins Univ, Dept Epidemiol, Bloomberg Sch Publ Hlth, Baltimore, MD 21287 USA.
   [Rochitte, Carlos E.] InCor Heart Inst, Dept Med Cardiol, Sao Paulo, Brazil.
   [Dewey, Marc] Charite, Dept Radiol, Berlin, Germany.
   [Chen, Marcus Y.] NHLBI, Cardiovasc & Pulm Branch, NIH, Bethesda, MD 20892 USA.
   [Clouse, Melvin E.] Beth Israel Deaconess Med Ctr, Dept Radiol, Boston, MA 02215 USA.
C3 Keio University; Johns Hopkins University; Johns Hopkins University;
   Johns Hopkins Bloomberg School of Public Health; Berlin Institute of
   Health; Free University of Berlin; Humboldt University of Berlin;
   Charite Universitatsmedizin Berlin; National Institutes of Health (NIH)
   - USA; NIH National Heart Lung & Blood Institute (NHLBI); Harvard
   University; Harvard University Medical Affiliates; Beth Israel Deaconess
   Medical Center
RP Arbab-Zadeh, A (corresponding author), Johns Hopkins Univ, Div Cardiol, 600 N Wolfe St,Blalock 524, Baltimore, MD 21287 USA.
EM azadeh1@jhmi.edu
RI ROCHITTE, CARLOS/GYH-2098-2022; Kishi, Satoru/AGZ-9683-2022; Rochitte,
   Carlos/M-1042-2017
OI Kishi, Satoru/0000-0001-6741-787X; Rochitte, Carlos/0000-0003-4505-3344;
   Dewey, Marc/0000-0002-4402-2733
FU Division of Intramural Research, National Heart, Lung, and Blood
   Institute, National Institutes of Health, United States; National
   Institutes of Health [K23HL098368]; Toshiba Medical Systems
FX This work was funded, in part, by the Division of Intramural Research,
   National Heart, Lung, and Blood Institute, National Institutes of
   Health, United States. Dr Arbab-Zadeh was funded by grant K23HL098368
   from the National Institutes of Health. The parent study for this
   research, the CORE320 multicenter study, was sponsored by Toshiba
   Medical Systems.
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NR 44
TC 69
Z9 71
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1941-9651
EI 1942-0080
J9 CIRC-CARDIOVASC IMAG
JI Circ.-Cardiovasc. Imaging
PD MAR
PY 2015
VL 8
IS 3
AR e002676
DI 10.1161/CIRCIMAGING.114.002676
PG 9
WC Cardiac & Cardiovascular Systems; Radiology, Nuclear Medicine & Medical
   Imaging
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Radiology, Nuclear Medicine &
   Medical Imaging
GA CG5CW
UT WOS:000353309700006
PM 25752899
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Cornish, ML
   Critchley, AT
   Mouritsen, OG
AF Cornish, M. Lynn
   Critchley, Alan T.
   Mouritsen, Ole G.
TI A role for dietary macroalgae in the amelioration of certain risk
   factors associated with cardiovascular disease
SO PHYCOLOGIA
LA English
DT Review
DE Antioxidants; Cardiovascular disease; Dietary fibre; Dietary seaweed;
   Macroalgae; Obesity; Seaweed consumption
ID DULSE PALMARIA-PALMATA; OXIDATIVE STRESS; ANTIOXIDANT CAPACITY;
   BLOOD-PRESSURE; FATTY-ACIDS; AMINO-ACIDS; SULFATED POLYSACCHARIDES;
   ERECTILE DYSFUNCTION; RESTRUCTURED MEATS; METABOLIC SYNDROME
AB Many of the pathologies leading to premature death from cardiovascular diseases (CVDs) in humans are influenced by an individual's nutritional habitus. Diet-related risk factors for these pervasive, noncommunicable diseases include obesity, hypertension, endothelial dysfunction, diabetes, and disproportionate cellular free-radical production. CVDs are the number one cause of premature death globally, and effective methods for ameliorating CVD risk factors associated with diet should be a primary target. Although various intervention strategies are being developed and implemented, such as healthy lunch programs, improved menus in school cafeterias, and government mandates for food manufacturers regarding the reduction of salt and trans fats in processed products, a broader, more universal approach is in order. The proliferation and ready availability of high-calorie, nutrient-poor foods and the powerful marketing tools used by multinational food companies seriously compromise the health and wellness potential of a significant proportion of the global population. In this review, some of the underlying mechanisms contributing to cardiovascular health are discussed in terms of human nutritional status. Unhealthy plasma cholesterol levels, obesity, nutritional energy imbalances, and inflammatory responses are identified as some of the likely precursors in the manifestation of cardiovascular issues. The favourable therapeutic impact dietary macroalgae could have by the provision of robust antioxidant suites, macro-and micronutritional elements, fibre content, and fatty acid profiles makes seaweeds viable and important contenders for involuntary intervention strategies related to food manufacturing. These components are discussed in relation to their functionality with respect to human health, and numerous edible macroalgae, such as Hypnea charoides, Mastocarpus stellatus, Palmaria palmata, Laminaria japonica, and Ulva pertusa are mentioned in light of their amelioration value. Opportunities for the practical utilization of marine macroalgae into ordinary foodstuffs are highlighted.
C1 [Cornish, M. Lynn] JS Craigie Res Ctr, Dartmouth, NS B0S 1H0, Canada.
   [Mouritsen, Ole G.] Univ Southern Denmark, Dept Phys Chem & Pharm, MEMPHYS Ctr Biomembrane Phys, DK-5230 Odense M, Denmark.
C3 University of Southern Denmark
RP Cornish, ML (corresponding author), JS Craigie Res Ctr, 82 Tribal St,Cornwallis Pk, Dartmouth, NS B0S 1H0, Canada.
EM lcornish@acadian.ca
RI Cornish, Lynn/AAJ-4703-2021; Critchley, Alan/AAB-1467-2019
OI Critchley, Alan/0000-0003-1704-458X; Mouritsen, Ole
   G./0000-0002-4258-8960
FU Lundbeckfonden [R95-A10447]
FX The work by O.G.M. is supported by Lundbeckfonden (re: R95-A10447).
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   Yang EJ, 2010, J ZHEJIANG UNIV-SC B, V11, P315, DOI 10.1631/jzus.B0900364
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   Yuan YV, 2005, FOOD CHEM TOXICOL, V43, P1073, DOI 10.1016/j.fct.2005.02.012
   Yuan YV, 2005, FOOD CHEM, V91, P485, DOI 10.1016/j.foodchem.2004.04.039
   Zhang Q, 2011, INT J ANDROL, V34, P225, DOI 10.1111/j.1365-2605.2010.01083.x
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NR 212
TC 36
Z9 40
U1 0
U2 52
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0031-8884
EI 2330-2968
J9 PHYCOLOGIA
JI Phycologia
PY 2015
VL 54
IS 6
BP 649
EP 666
DI 10.2216/15-77.1
PG 18
WC Plant Sciences; Marine & Freshwater Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Marine & Freshwater Biology
GA CX8ZT
UT WOS:000365995200011
DA 2025-06-11
ER

PT J
AU Zhang, J
   Xiang, G
   Xiang, L
   Sun, H
AF Zhang, J.
   Xiang, G.
   Xiang, L.
   Sun, H.
TI Serum uric acid is associated with arterial stiffness in men with newly
   diagnosed type 2 diabetes mellitus
SO JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
LA English
DT Article
DE Serum uric acid; Pulse wave velocity; Arterial stiffness; Type 2
   diabetes mellitus
ID PULSE-WAVE VELOCITY; IMPAIRED FASTING GLUCOSE; METABOLIC SYNDROME;
   ENDOTHELIAL DYSFUNCTION; CELL-PROLIFERATION; INSULIN-RESISTANCE;
   OXIDATIVE STRESS; RISK-FACTORS; ATHEROSCLEROSIS; HYPERTENSIVES
AB Background Increased serum uric acid levels and vascular atherosclerosis are very common in diabetes. However, few studies focused on the relationship between serum uric acid and aortic or peripheral arterial stiffness in newly diagnosed diabetic patients. This study investigated the association between serum uric acid levels and carotid-femoral pulse wave velocity (cfPWV) or carotid-radial (cr) PWV in male patients with newly diagnosed type 2 diabetes mellitus (T2DM).
   Methods 106 male patients with newly diagnosed T2DM were recruited. cfPWV and crPWV as well as anthropometric parameters, blood pressure, serum uric acid, blood glucose, fasting insulin, C-reactive protein and blood lipids were measured.
   Results The subjects were divided into low uric acid (UA) subgroup and high UA subgroup according to uric acid median. cfPWV and crPWV were significantly higher in high UA subgroup. Serum uric acid significantly correlated with cfPWV (r = 0.533, P < 0.001), crPWV (r = 0.334, P = 0.001), waist circumference (r = 0.350, P < 0.001), waist-to-hip ratio (r = 0.254, P = 0.009), fasting insulin (r = 0.432, P < 0.001), HOMA-IR (r = 0.173, P = 0.042), fasting blood glucose (r = -0.271, P = 0.005), haemoglobin A1c (r = -0.202, P = 0.038), and HDL-cholesterol (r = -0.267, P = 0.006) after correction for age. Stepwise multiple regressions showed that the independent determinants of cfPWV were serum uric acid, age, C-reactive protein, HDL-cholesterol, and smoking status. And the independent determinants of crPWV were serum uric acid, age, diastolic blood pressure, and HDL-cholesterol.
   Conclusions Serum uric acid is significantly associated with increased aortic and peripheral arterial stiffness in men with T2DM at the early stage.
C1 [Zhang, J.; Xiang, G.; Xiang, L.; Sun, H.] Wuhan Gen Hosp Guangzhou Command, Dept Endocrinol, Wuhan 430070, Hubei, Peoples R China.
RP Zhang, J (corresponding author), Wuhan Gen Hosp Guangzhou Command, Dept Endocrinol, Wuluo Rd 627, Wuhan 430070, Hubei, Peoples R China.
EM zhangjx666@gmail.com
RI Kurt, Omer/G-7504-2015
OI Kurt, Omer/0000-0001-8045-1036
CR Baldwin W, 2011, DIABETES, V60, P1258, DOI 10.2337/db10-0916
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NR 30
TC 16
Z9 18
U1 1
U2 7
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1720-8386
J9 J ENDOCRINOL INVEST
JI J. Endocrinol. Invest.
PD MAY
PY 2014
VL 37
IS 5
BP 441
EP 447
DI 10.1007/s40618-013-0034-9
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA AG1CN
UT WOS:000335152700004
PM 24682912
DA 2025-06-11
ER

PT J
AU Ravn-Haren, G
   Dragsted, LO
   Buch-Andersen, T
   Jensen, EN
   Jensen, RI
   Németh-Balogh, M
   Paulovicsová, B
   Bergström, A
   Wilcks, A
   Licht, TR
   Markowski, J
   Bügel, S
AF Ravn-Haren, Gitte
   Dragsted, Lars O.
   Buch-Andersen, Tine
   Jensen, Eva N.
   Jensen, Runa I.
   Nemeth-Balogh, Maria
   Paulovicsova, Brigita
   Bergstrom, Anders
   Wilcks, Andrea
   Licht, Tine R.
   Markowski, Jaroslaw
   Bugel, Susanne
TI Intake of whole apples or clear apple juice has contrasting effects on
   plasma lipids in healthy volunteers
SO EUROPEAN JOURNAL OF NUTRITION
LA English
DT Article
DE Apples; Pomace; Clear juice; Blood lipids; CVD; ISAFRUIT
ID DIETARY FIBER INTAKE; CORONARY-HEART-DISEASE; GRADIENT
   GEL-ELECTROPHORESIS; CARDIOVASCULAR-DISEASE; FLAVONOID INTAKE; FRUIT
   JUICE; GLUTATHIONE PEROXIDASE-1; METABOLIC SYNDROME; OXIDATIVE STRESS;
   FECAL MICROBIOTA
AB Fruit consumption is associated with a decreased risk of CVD in cohort studies and is therefore endorsed by health authorities as part of the '5 or more a day' campaigns. A glass of fruit juice is generally counted as one serving. Fruit may cause protection by affecting common risk factors of CVD.
   Apples are among the most commonly consumed fruits and were chosen for a comprehensive 5 x 4 weeks dietary crossover study to assess the effects of whole apples (550 g/day), apple pomace (22 g/day), clear and cloudy apple juices (500 ml/day), or no supplement on lipoproteins and blood pressure in a group of 23 healthy volunteers.
   The intervention significantly affected serum total and LDL-cholesterol. Trends towards a lower serum LDL-concentration were observed after whole apple (6.7 %), pomace (7.9 %) and cloudy juice (2.2 %) intake. On the other hand, LDL-cholesterol concentrations increased by 6.9 % with clear juice compared to whole apples and pomace. There was no effect on HDL-cholesterol, TAG, weight, waist-to-hip ratio, blood pressure, inflammation (hs-CRP), composition of the gut microbiota or markers of glucose metabolism (insulin, IGF1 and IGFBP3).
   Apples are rich in polyphenols and pectin, two potentially bioactive constituents; however, these constituents segregate differently during processing into juice products and clear juice is free of pectin and other cell wall components. We conclude that the fibre component is necessary for the cholesterol-lowering effect of apples in healthy humans and that clear apple juice may not be a suitable surrogate for the whole fruit in nutritional recommendations.
C1 [Ravn-Haren, Gitte; Dragsted, Lars O.; Buch-Andersen, Tine; Jensen, Eva N.; Jensen, Runa I.; Nemeth-Balogh, Maria; Paulovicsova, Brigita; Bugel, Susanne] Univ Copenhagen, Fac Sci, Dept Nutr Exercise & Sports, Frederiksberg, Denmark.
   [Ravn-Haren, Gitte] Tech Univ Denmark, Natl Food Inst, Div Toxicol & Risk Assessment, DK-2860 Soborg, Denmark.
   [Nemeth-Balogh, Maria; Paulovicsova, Brigita] Slovak Univ Agr, Fac Agrobiol & Food Resources, Dept Human Nutr, Nitra, Slovakia.
   [Bergstrom, Anders; Wilcks, Andrea; Licht, Tine R.] Tech Univ Denmark, Natl Food Inst, Div Food Microbiol, DK-2860 Soborg, Denmark.
   [Markowski, Jaroslaw] Res Inst Pomol & Floriculture, Dept Storage & Proc, Skierniewice, Poland.
C3 University of Copenhagen; Technical University of Denmark; Slovak
   University of Agriculture Nitra; Technical University of Denmark
RP Ravn-Haren, G (corresponding author), Tech Univ Denmark, Natl Food Inst, Div Toxicol & Risk Assessment, Morkhoj Bygade 19, DK-2860 Soborg, Denmark.
EM girh@food.dtu.dk
RI Andersen, Anders/AAV-5053-2021; Andersen, Tine/KUF-4595-2024; Dragsted,
   Lars/AAT-1713-2020; Dragsted, Lars Ove/N-3384-2014; Bugel,
   Susanne/B-1557-2015; Markowski, Jaroslaw/E-8677-2015; Ravn-Haren,
   Gitte/I-8551-2018
OI Licht, Tine Rask/0000-0002-6399-9574; Dragsted, Lars
   Ove/0000-0003-0609-6317; Bugel, Susanne/0000-0003-4299-0500; Markowski,
   Jaroslaw/0000-0002-2123-0046; , Anders/0000-0003-0961-0799;
   Buch-Andersen, Tine/0000-0003-1275-6713; Ravn-Haren,
   Gitte/0000-0002-4587-089X
FU Commission of the European Communities [016279]
FX This work was supported by the Commission of the European Communities
   under the Sixth Framework Programme: Food Quality and Safety, contract
   no. 016279 'Increasing fruit consumption through a trans-disciplinary
   approach delivering high quality produce from environmentally friendly,
   sustainable production methods (ISAFRUIT)'. It does not necessarily
   reflect its view and in no way anticipates the Commission's policy in
   this area. We thank all the persons who volunteered for this study,
   Hanne L. Pedersen, Vibeke Kegel, Berit Hoielt, Karina G. Rossen, Annette
   Landin, Bodil Madsen, Kate V. Vibefeldt, Pia Madsen and Lars Bentzen for
   excellent technical support and Claude Mona for her assistance with the
   proofreading of the final draft version of the manuscript.
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NR 70
TC 126
Z9 134
U1 3
U2 91
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1436-6207
EI 1436-6215
J9 EUR J NUTR
JI Eur. J. Nutr.
PD DEC
PY 2013
VL 52
IS 8
BP 1875
EP 1889
DI 10.1007/s00394-012-0489-z
PG 15
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 256QW
UT WOS:000327330000005
PM 23271615
DA 2025-06-11
ER

PT J
AU Ramadan, G
   El-Menshawy, O
AF Ramadan, Gamal
   El-Menshawy, Omar
TI Protective effects of ginger-turmeric rhizomes mixture on joint
   inflammation, atherogenesis, kidney dysfunction and other complications
   in a rat model of human rheumatoid arthritis
SO INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
LA English
DT Article
DE adjuvant-induced arthritis; albino rats; articular; extra-articular
   manifestations; ginger-turmeric mixture; indomethacin
ID ADJUVANT-INDUCED ARTHRITIS; PORPHYROMONAS-GINGIVALIS; METABOLIC
   SYNDROME; CURCUMIN; EXPRESSION; PROTEIN-1; CARTILAGE; TOXICITY;
   EXTRACTS; EFFICACY
AB Aim Besides joint destruction, extra-articular complications (outside the locomotor system) are frequent in rheumatoid arthritis (RA) patients, especially cardiovascular, hematological and metabolic disorders. Here, we evaluated and compared the protective activity of two different doses of mixture of ginger and turmeric rhizomes powder (1:1) suspended in distilled water (GTaq) in alleviating both articular and extra-articular manifestations in rat adjuvant-induced arthritis (AIA). Methods Arthritis was induced by a single intra-dermal injection of 0.1mL of Complete Freund's adjuvant (containing heat-killed Mycobacterium tuberculosis) into the palmar surface of the left hind paw after the rats were subjected to light diethyl ether anesthesia. Arthritic rats received orally and daily (for 28 consecutive days) distilled water as vehicle, indomethacin (1.0mg/kg body weight), or GTaq (200 or 400mg/kg body weight) from the day of arthritis induction. Results The present study showed that GTaq (especially the high dose) was more effective (4.2-38.4% higher, P<0.05-0.001) than indomethacin (a non-steroidal/anti-inflammatory drug) in alleviating the loss in body weight gain, the histopathological changes observed in ankle joints, blood leukocytosis and thrombocytosis, iron deficiency anemia, serum hypoalbuminemia and globulinemia, the impairment of kidney functions, and the risks for cardiovascular disease in arthritic rats. These protective effects of GTaq were mediated through increasing the food intake and decreasing the systemic inflammation that occur at the appearance of polyarthritis, oxidative stress and dyslipidemia. Conclusion Ginger-turmeric rhizomes mixture may be effective against RA severity and complications as shown in an AIA rat model.
C1 [Ramadan, Gamal; El-Menshawy, Omar] King Faisal Univ, Dept Biol Sci, Coll Sci, Al Hufof, Saudi Arabia.
   [Ramadan, Gamal] Ain Shams Univ, Dept Zool, Fac Sci, Cairo 11566, Egypt.
   [El-Menshawy, Omar] Al Azhar Univ, Fac Sci, Dept Zool, Cairo, Egypt.
C3 King Faisal University; Egyptian Knowledge Bank (EKB); Ain Shams
   University; Egyptian Knowledge Bank (EKB); Al Azhar University
RP Ramadan, G (corresponding author), Ain Shams Univ, Dept Zool, Fac Sci, Cairo 11566, Egypt.
EM gamal_ramadan@hotmail.com
RI Ramadan, Gamal/A-8666-2012; Elmenshawy, Omar/I-6030-2016
OI Ramadan, Gamal/0000-0002-3357-0216; Elmenshawy, Omar/0000-0002-7259-8393
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NR 43
TC 43
Z9 46
U1 0
U2 37
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1756-1841
EI 1756-185X
J9 INT J RHEUM DIS
JI Int. J. Rheum. Dis.
PD APR
PY 2013
VL 16
IS 2
BP 219
EP 229
DI 10.1111/1756-185X.12054
PG 11
WC Rheumatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Rheumatology
GA 166JC
UT WOS:000320549700019
PM 23773648
DA 2025-06-11
ER

PT J
AU Aksakal, E
   Tanboga, IH
   Kurt, M
   Kaygin, MA
   Kaya, A
   Isik, T
   Ekinci, M
   Sevimli, S
   Acikel, M
AF Aksakal, Enbiya
   Tanboga, Ibrahim Halil
   Kurt, Mustafa
   Kaygin, Mehmet Ali
   Kaya, Ahmet
   Isik, Turgay
   Ekinci, Mehmet
   Sevimli, Serdar
   Acikel, Mahmut
TI The relation of serum gamma-glutamyl transferase levels with coronary
   lesion complexity and long-term outcome in patients with stable coronary
   artery disease
SO ATHEROSCLEROSIS
LA English
DT Article
DE Serum gamma-glutamyl transferase; SYNTAX score
ID C-REACTIVE PROTEIN; CARDIOVASCULAR-DISEASE; OXIDATIVE STRESS; METABOLIC
   SYNDROME; AUSTRIAN ADULTS; SYNTAX SCORE; URIC-ACID; ATHEROSCLEROSIS;
   SEVERITY; ASSOCIATION
AB Background: Relation of serum gamma-glutamyl transferase (GGT) levels with extent, severity, and complexity of coronary artery disease has not been adequately studied. Therefore, we evaluated the relationship between GGT levels and coronary complexity, severity and extent assessed by SYNTAX score and long-term adverse events.
   Methods: We enrolled 442 consecutive patients with stable angina pectoris who underwent coronary angiography. Baseline serum GGT levels were measured and SYNTAX score was calculated from the study population. Median follow-up duration was 363 days. Endpoints were all cause mortality and any revascularization.
   Results: GGT levels demonstrated an increase from low SYNTAX tertile to high tertile. In multivariate analysis serum GGT, diabetes mellitus, HDL-cholesterol, eGFR and ejection fraction were found to be independent predictors of high SYNTAX score. The survival analysis showed that long-term revascularization rates were comparable between the GGT groups (for 36 U/l cut point) of the overall population (7.7% vs 8.6% logrank, p = 0.577), whereas long-term all cause mortality rate was higher in the GGT >= 36 U/l group (3.6% vs 11.6% logrank, p = 0.001). In Cox proportional hazards regression model, GGT = 36 U/l group was found to be an independent predictor of long-term all cause mortality in the unadjusted (HR 2.54, 95% CI 1.17-5.48, p = 0.018) and age-and gender-adjusted (HR 2.58, 95% CI 1.19-5.58, p = 0.016) models.
   Conclusion: Serum GGT level was independently associated with coronary complexity and long-term mortality in patients with stable coronary artery disease. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
C1 [Aksakal, Enbiya; Sevimli, Serdar; Acikel, Mahmut] Ataturk Univ, Sch Med, Dept Cardiol, Erzurum, Turkey.
   [Tanboga, Ibrahim Halil; Kurt, Mustafa; Kaygin, Mehmet Ali; Kaya, Ahmet; Isik, Turgay; Ekinci, Mehmet] Erzurum Educ & Res Hosp, Dept Cardiol, Erzurum, Turkey.
C3 Ataturk University; Erzurum Bolge Training & Research Hospital
RP Aksakal, E (corresponding author), Ataturk Univ, Tip Fak, Kardiyol Ana Bilimdali, Erzurum, Turkey.
EM drenbiya@yahoo.com
RI ışık, Turgay/JVZ-5574-2024; Tanboga, Ibrahim/E-8886-2010; KAYA,
   AHMET/AAS-5392-2021
OI Tanboga, Ibrahim Halil/0000-0003-4546-9227; TURGAY,
   ISIK/0000-0002-7090-8765
CR Açikel M, 2009, ANATOL J CARDIOL, V9, P273
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NR 31
TC 42
Z9 47
U1 0
U2 20
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0021-9150
EI 1879-1484
J9 ATHEROSCLEROSIS
JI Atherosclerosis
PD APR
PY 2012
VL 221
IS 2
BP 596
EP 601
DI 10.1016/j.atherosclerosis.2012.01.044
PG 6
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 914TI
UT WOS:000301974900047
PM 22369933
DA 2025-06-11
ER

PT J
AU Mork, PJ
   Vasseljen, O
   Nilsen, TIL
AF Mork, Paul J.
   Vasseljen, Ottar
   Nilsen, Tom I. L.
TI Association Between Physical Exercise, Body Mass Index, and Risk of
   Fibromyalgia: Longitudinal Data From the Norwegian Nord-Trondelag Health
   Study
SO ARTHRITIS CARE & RESEARCH
LA English
DT Article
ID LOW-BACK-PAIN; PROINFLAMMATORY CYTOKINES; MUSCULOSKELETAL PAIN;
   GENERAL-POPULATION; METABOLIC SYNDROME; AEROBIC EXERCISE; OBESITY;
   STRESS; WOMEN; NECK
AB Objective. To examine the association between leisure time physical exercise, body mass index (BMI), and risk of fibromyalgia (FM).
   Methods. A longitudinal study with baseline assessment of physical exercise (frequency, duration, and intensity) and BMI was used to explore the risk of having FM at 11-year followup in a large, unselected female population (n = 15,990) without FM or physical impairments at baseline.
   Results. At followup, 380 cases of incident FM were reported. A weak dose-response association was found between level of physical exercise and risk of FM (for trend, P = 0.13) where women who reported the highest exercise level had a relative risk (RR) of 0.77 (95% confidence interval [95% CI] 0.55-1.07). BMI was an independent risk factor for FM (for trend, P < 0.001), and overweight or obese women (BMI >= 25.0 kg/m(2)) had a 60-70% higher risk compared with women with normal weight (BMI 18.5-24.9 kg/m(2)). Overweight or obese women who exercised >= 1 hour per week had an RR of 1.72 (95% CI 1.07-2.76) compared with normal-weight women with a similar activity level, whereas the risk was > 2-fold higher for overweight or obese women who were either inactive (RR 2.09, 95% CI 1.36-3.21) or exercised <1 hour per week (RR 2.19, 95% CI 1.39-3.46).
   Conclusion. Being overweight or obese was associated with an increased risk of FM, especially among women who also reported low levels of physical exercise. Community-based measures aimed at reducing the incidence of FM should emphasize the importance of regular exercise and the maintenance of normal body weight.
C1 [Mork, Paul J.] Norwegian Univ Sci & Technol, Human Movement Sci Programme, N-7491 Trondheim, Norway.
C3 Norwegian University of Science & Technology (NTNU)
RP Mork, PJ (corresponding author), Norwegian Univ Sci & Technol, Human Movement Sci Programme, N-7491 Trondheim, Norway.
EM paul.mork@svt.ntnu.no
RI Mork, Paul/E-4509-2010
OI Vasseljen, Ottar/0000-0001-6287-5871
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NR 50
TC 137
Z9 145
U1 2
U2 15
PU WILEY-LISS
PI HOBOKEN
PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 2151-464X
J9 ARTHRIT CARE RES
JI Arthritis Care Res.
PD MAY
PY 2010
VL 62
IS 5
BP 611
EP 617
DI 10.1002/acr.20118
PG 7
WC Rheumatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Rheumatology
GA 639MT
UT WOS:000280979600005
PM 20191480
DA 2025-06-11
ER

PT J
AU Oliver, SR
   Flores, RL
   Pontello, AM
   Rosa, JS
   Zaldivar, FP
   Galassetti, PR
AF Oliver, Stacy R.
   Flores, Rebecca L.
   Pontello, Andria M.
   Rosa, Jaime S.
   Zaldivar, Frank P.
   Galassetti, Pietro R.
TI Acute suppression of circulating sCD40L during hyperglycemia and
   euglycemic-hyperinsulinemia in healthy young males
SO JOURNAL OF INVESTIGATIVE MEDICINE
LA English
DT Article
DE sCD40L; cytokines; insulin; healthy; young males
ID SOLUBLE CD40 LIGAND; TYPE-2 DIABETES-MELLITUS; EPIDERMAL-GROWTH-FACTOR;
   C-REACTIVE PROTEIN; ENDOTHELIAL-CELLS; OXIDATIVE STRESS; TISSUE FACTOR;
   CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; P-SELECTIN
AB sCD40L is a proatherogenic cytokine, part of the tumor necrosis factor (TNF) superfamily and consistently associated with obesity, diabetes, and increased cardiovascular risk. Although the role of sCD40L in the onset/ progression of cardiovascular complications of dysmetabolic diseases may be modulated by acute and/or chronic fluctuations of plasma insulin and glucose, very little has been done to clarify this interaction. The kinetic profile of sCD40L (and, in an exploratory manner, of several nomodulatory factors), were measured during hyperglycemia and euglycemic-hyperinsulinemia in a group of 10 healthy Young males (26.8 +/- 1.4 years). After an overnight fast, intravenous (iv) catheters were placed in antecubital veins of both arms for blood drawing and dextrose/insulin iv infusions. Procedures lasted 240 minutes including baseline (t = 0-60), hyperglycernia (t = 60-150; plasma glucose similar to 220 mg/dL via iv dextrose infusion),. and euglycemic-hyperinsulinemia (t = 150-240; glucose infusion continued to clamp glycemic levels between 80 and 110 mg/dL constant insulin infusion at 1.5 mU/kg/minute).
   Plasma for cytokine assays was sampled at 12 separate time-points. Plasma levels of sCD40L were significantly reduced (P < 0.01) during hyperglycernia and euglycemic-hyperinsulinemia, paralleling the kinetic profiles of free fatty acids and ketone bodies. This pattern was also observed in other immunomodulatory factors (notably cortisol and epidermal growth factor), while (interleukin [IL]-1 alpha, IL-41 IL-6, IL-9, IL-10, TNF-alpha. Eotaxin) did not change significantly. Significant reductions of the proatherogenic cytokine sCD40L were observed during endogenous and exogenous hyperinsulinemia, independent of prevailing glucose concentration, in young healthy males. Our data suggest a mechanism by which correct insulin action may exert a beneficial protective role against inflammation, independent of its immediate glucose-lowering effect.
C1 [Oliver, Stacy R.; Flores, Rebecca L.; Pontello, Andria M.; Rosa, Jaime S.; Zaldivar, Frank P.; Galassetti, Pietro R.] Univ Calif Irvine, Inst Clin Translat Sci Ctr, Dept Pediat, Orange, CA 92868 USA.
   [Rosa, Jaime S.; Galassetti, Pietro R.] Univ Calif Irvine, Sch Med, Dept Pharmacol, Irvine, CA 92717 USA.
C3 University of California System; University of California Irvine;
   University of California System; University of California Irvine
RP Oliver, SR (corresponding author), Univ Calif Irvine, Inst Clin Translat Sci Ctr, Dept Pediat, Bldg 25,2nd Floor,101 The City Dr, Orange, CA 92868 USA.
EM soliver@uci.edu
RI Stefanadis, Christodoulos/ABH-2232-2020; Rosa Duque, Jaime
   S/HDO-5704-2022
OI Stefanadis, Christodoulos/0000-0001-5974-6454; Rosa Duque, Jaime
   S/0000-0002-5292-5510
FU NIH [M01-RR00827-28]; JDRF [1-2006-76]
FX This research was supported by NIH grants M01-RR00827-28 and JDRF grant
   #1-2006-76.
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NR 55
TC 3
Z9 4
U1 0
U2 0
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 1081-5589
EI 1708-8267
J9 J INVEST MED
JI J. Invest. Med.
PD OCT
PY 2008
VL 56
IS 7
BP 902
EP 910
DI 10.2310/JIM.0b013e31818914e4
PG 9
WC Medicine, General & Internal; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Research & Experimental Medicine
GA 358YV
UT WOS:000259954300007
PM 18797414
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Catov, JM
   Bodnar, LM
   Ness, RB
   Barron, SJ
   Roberts, JM
AF Catov, Janet M.
   Bodnar, Lisa M.
   Ness, Roberta B.
   Barron, Stacy J.
   Roberts, James M.
TI Inflammation and dyslipidemia related to risk of spontaneous preterm
   birth
SO AMERICAN JOURNAL OF EPIDEMIOLOGY
LA English
DT Article
DE cardiovascular diseases; cholesterol; C-reactive protein; dyslipidemias;
   inflammation; premature birth; triglycerides; women
ID C-REACTIVE-PROTEIN; MATERNAL CARDIOVASCULAR RISK; BODY-MASS-INDEX;
   PREGNANCY COMPLICATIONS; METABOLIC SYNDROME; OXIDATIVE STRESS; OBESITY;
   WEIGHT; PREECLAMPSIA; ASSOCIATION
AB Women who deliver preterm are at increased risk for cardiovascular disease, but mechanisms are not understood. The authors considered that inflammation in women with spontaneous preterm birth (sPTB) might be related to their metabolic profile, such as lipids, and tested this in a nested case-control study from the Pregnancy Exposures and Preeclampsia Prevention Study (1997-2001). Cases were women with sPTB at 34-< 37 weeks (n = 76) or < 34 weeks (n = 33). Controls were randomly selected women with term births (n = 228). Early pregnancy inflammation (C-reactive protein: >= 8 mu g/ml) and dyslipidemia (cholesterol: > 230 mg/dl or triglycerides: > 140 mg/dl) were evaluated in serum collected at < 21 weeks. Late pregnancy elevated C-reactive protein (>= 12 mu g/ml) was measured in a subset (n = 295). Polycotomous logistic regression was used to estimate the joint effects of C-reactive protein elevations and dyslipidemia on the risk of sPTB subtypes. After adjustment for race, body mass index, periconceptional vitamin use, and gestational age at sampling, early pregnancy inflammation (odds ratio = 2.9, 95% confidence interval (CI): 1.1, 7.2) and dyslipidemia (odds ratio = 2.0, 95% CI: 1.0, 4.2) were independently associated with sPTB at 34-< 37 weeks. The presence of both conditions increased risk of sPTB at < 34 weeks 6.4-fold (95% CI: 1.7, 24.1). Half of the women with early pregnancy inflammation had elevated C-reactive protein late in gestation, and each was independently related to the risk of sPTB at < 34 weeks. The results indicate that some metabolic factors together with inflammation may be related to the risk of sPTB.
C1 Univ Pittsburgh, Dept Epidemiol, Pittsburgh, PA 15261 USA.
   Magee Womens Res Inst, Pittsburgh, PA USA.
   Univ Pittsburgh, Dept Obstet Gynecol & Reprod Sci, Pittsburgh, PA 15261 USA.
   Emory Univ, Dept Biol, Atlanta, GA 30322 USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE); University
   of Pittsburgh; Pennsylvania Commonwealth System of Higher Education
   (PCSHE); University of Pittsburgh; Magee-Womens Research Institute;
   Pennsylvania Commonwealth System of Higher Education (PCSHE); University
   of Pittsburgh; Emory University
RP Catov, JM (corresponding author), Univ Pittsburgh, Dept Epidemiol, 130 DeSoto St, Pittsburgh, PA 15261 USA.
EM jmcst43@pitt.edu
RI Roberts, James/AAI-3283-2020; Bodnar, Lisa/W-3978-2019
OI Bodnar, Lisa M/0000-0001-9427-5467
CR Albert MA, 2001, JAMA-J AM MED ASSOC, V286, P64, DOI 10.1001/jama.286.1.64
   [Anonymous], PRETERM BIRTH CAUSES
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NR 35
TC 120
Z9 131
U1 0
U2 5
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0002-9262
EI 1476-6256
J9 AM J EPIDEMIOL
JI Am. J. Epidemiol.
PD DEC 1
PY 2007
VL 166
IS 11
BP 1312
EP 1319
DI 10.1093/aje/kwm273
PG 8
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA 232QN
UT WOS:000251034300012
PM 17906337
OA Bronze
DA 2025-06-11
ER

PT J
AU Zhang, LF
   Li, Y
   Zhang, Y
   Cai, Y
   Li, L
   Ying, LS
   Wang, Q
   Hu, J
   Jia, CS
   Wu, CY
   Bao, YL
   Jiang, F
   Yan, W
   Zeng, N
AF Zhang, Lanfang
   Li, Yuan
   Zhang, Yan
   Cai, Yuan
   Li, Lin
   Ying, Lisheng
   Wang, Qian
   Hu, Jie
   Jia, Changsha
   Wu, Chuyan
   Bao, Yunlei
   Jiang, Feng
   Yan, Wen
   Zeng, Ni
TI Development and trends in metabolomics studies in psoriasis: A
   bibliometric analysis of related research from 2011 to 2024
SO HELIYON
LA English
DT Article
DE Bibliometrics; Metabolomics; Psoriasis; VOSviewers; CiteSpace
ID OXIDATIVE STRESS; PLAQUE PSORIASIS; INFLAMMATION; ETANERCEPT;
   MECHANISMS; PATHOGENESIS; METABOLISM; BIOMARKERS; CHILDREN; SMOKING
AB Background: Psoriasis is a chronic, inflammatory skin disease with autoimmune characteristics. Recent research has made significant progress in the field of psoriasis metabolomics. However, there is a lack of bibliometric analysis on metabolomics of psoriasis. The objective of this study is to utilize bibliometrics to present a comprehensive understanding of the knowledge structure and research hotspots in psoriasis within the field of metabolomics. Methods: We conducted a bibliometric analysis by searching the Web of Science Core Collection database for publications on metabolomics in psoriasis from 2011 to 2024. To perform this analysis, we utilized tools such as VOSviewers, CiteSpace, and the R package "bibliometrix". Results: A total of 307 articles from 47 countries, with the United States and China leading the way, were included in the analysis. The publications focusing on metabolomics in psoriasis have shown a steady year-on-year growth. The Medical University of Bialystok is the main research institution. The International Journal of Molecular Sciences emerges as the prominent journal in the field, while the Journal of Investigative Dermatology stands out as the highly co-cited publication. A total of 2029 authors contributed to these publications, with Skrzydlewska Elzbieta, Baran Anna, Flisiak Iwona, Murakami Makoto being the most prolific contributors. Notably, Armstrong April W. received the highest co-citation. Investigating the mechanisms of metabolomics in the onset and progression of psoriasis, as well as exploring therapeutic strategies, represents the primary focus of this research area. Emerging research hotspots encompass inflammation, lipid metabolism, biomarker, metabolic syndrome, obesity, and arthritis. Conclusion: The results of this study indicate that metabolism-related research is thriving in psoriasis, with a focus on the investigation of metabolic targets and interventions within the metabolic processes. Metabolism is expected to be a hot topic in future psoriasis research.
C1 [Zhang, Lanfang; Zhang, Yan; Cai, Yuan; Li, Lin; Ying, Lisheng; Hu, Jie; Jia, Changsha; Yan, Wen; Zeng, Ni] Zunyi Med Univ, Affiliated Hosp, Dept Dermatol, Zunyi, Peoples R China.
   [Li, Yuan] Fifth Peoples Hosp Hainan Prov, Dept Dermatol, Haikou, Peoples R China.
   [Wang, Qian] Zunyi Med Univ, Affiliated Hosp, Dept Endocrinol, Zunyi, Peoples R China.
   [Wu, Chuyan] Nanjing Med Univ, Affiliated Hosp 1, Dept Rehabil Med, Nanjing, Peoples R China.
   [Bao, Yunlei; Jiang, Feng] Fudan Univ, Dept Neonatol, Obstet & Gynecol Hosp, Shanghai, Peoples R China.
C3 Zunyi Medical University; Zunyi Medical University; Nanjing Medical
   University; Fudan University
RP Yan, W; Zeng, N (corresponding author), Zunyi Med Univ, Affiliated Hosp, Dept Dermatol, Zunyi, Peoples R China.; Jiang, F (corresponding author), Fudan Univ, Dept Neonatol, Obstet & Gynecol Hosp, Shanghai, Peoples R China.
EM dxyjiang@163.com; zyyanwen@163.com; jennyfantasyzmu@hotmail.com
RI zeng, ni/ABF-5358-2021; wu, chuyan/ABH-1698-2021; Zhang,
   Lanfang/KXQ-8174-2024; Jiang, Feng/ABF-1663-2021
OI Jiang, Feng/0000-0002-3525-8752
FU Natural Science Foundation of Guizhou Province [578]; Zunyi Foundation
   for Development of Science and Technology [319]; Hainan Province
   Clinical Medical Center
FX <STRONG>This work was supported by the Natural Science Foundation of
   Guizhou Province (ZK2023-No.578) , the Zunyi Foundation for Development
   of Science and Technology (HZ2022-No.319) and Hainan Province Clinical
   Medical Center. </STRONG>
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NR 70
TC 2
Z9 2
U1 7
U2 15
PU CELL PRESS
PI CAMBRIDGE
PA 50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA
EI 2405-8440
J9 HELIYON
JI Heliyon
PD APR 30
PY 2024
VL 10
IS 8
AR e29794
DI 10.1016/j.heliyon.2024.e29794
EA APR 2024
PG 17
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA YH1H7
UT WOS:001267501000001
PM 38681652
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Francque, SM
AF Francque, Sven M.
TI Towards precision medicine in non-alcoholic fatty liver disease
SO REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
LA English
DT Review
DE NAFLD; Liver steatosis; Genetics; Disease heterogeneity; Treatment
   response
ID LIFE-STYLE MODIFICATION; METABOLIC FLEXIBILITY; INSULIN-RESISTANCE;
   GENETIC-VARIATION; WEIGHT-LOSS; PNPLA3; RISK; FIBROSIS; NAFLD;
   STEATOHEPATITIS
AB Non-Alcoholic Fatty Liver Disease (NAFLD) refers to the accumulation of lipid laden vacuoles in hepatocytes, occurring in the context of visceral adiposity, insulin resistance and other features of the metabolic syndrome. Its more severe form (NASH, Non-Alcoholic Steatohepatitis) is becoming the leading aetiology of end-stage liver disease and hepatocellular carcinoma, and also contributes to cardiovascular disease, diabetes and extrahepatic malignancy. Management is currently limited to lifestyle modification and optimisation of the metabolic co-morbidities, with some of the drugs used for the latter also having shown some benefit for the liver. Licensed treatment modalities are currently lacking. A particular difficulty is the notorious heterogeneity of the patient population, which is poorly understood. A spectrum of disease severity associates in a non-linear way with a spectrum of severity of underlying metabolic factors. Heterogeneity of the liver in terms of mechanisms to cope with the metabolic and inflammatory stress and in terms of repair mechanisms, and a lack of knowledge hereof, further complicate the understanding of inter-individual variability. Genetic factors act as disease modifiers and potentially allow for some risk stratification, but also only explain a minor fraction of disease heterogeneity. Response to treatment shows a large variation in treatment response, again with little understanding of what is driving the absence of response in individual patients. Management can be tailored to patient's preferences in terms of diet modification, but tailoring treatment to knowledge on disease driving mechanisms in an individual patient is still in its infancy. Recent progress in analysing liver tissue as well as non-invasive tests hold, however, promise to rapidly improve our understanding of disease heterogeneity in NAFLD and provide individualised management.
C1 [Francque, Sven M.] Antwerp Univ Hosp, Dept Gastroenterol Hepatol, Drie Eikenst 655, B-2650 Edegem, Belgium.
   [Francque, Sven M.] Univ Antwerp, Fac Med & Hlth Sci, InflaMed Ctr Excellence, Lab Expt Med & Paediat, Universiteitspl 1, B-2610 Antwerp, Belgium.
C3 University of Antwerp; University of Antwerp
RP Francque, SM (corresponding author), Antwerp Univ Hosp, Dept Gastroenterol Hepatol, Drie Eikenst 655, B-2650 Edegem, Belgium.; Francque, SM (corresponding author), Univ Antwerp, Fac Med & Hlth Sci, InflaMed Ctr Excellence, Lab Expt Med & Paediat, Universiteitspl 1, B-2610 Antwerp, Belgium.
EM sven.francque@uza.be
RI Francque, sven/E-4526-2017
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NR 127
TC 15
Z9 15
U1 0
U2 6
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1389-9155
EI 1573-2606
J9 REV ENDOCR METAB DIS
JI Rev. Endocr. Metab. Disord.
PD OCT
PY 2023
VL 24
IS 5
SI SI
BP 885
EP 899
DI 10.1007/s11154-023-09820-6
EA JUL 2023
PG 15
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA R1PW0
UT WOS:001034271800001
PM 37477772
DA 2025-06-11
ER

PT J
AU Surma, S
   Sahebkar, A
   Banach, M
AF Surma, Stanislaw
   Sahebkar, Amirhossein
   Banach, Maciej
TI Coffee or tea: Anti-inflammatory properties in the context of
   atherosclerotic cardiovascular disease prevention
SO PHARMACOLOGICAL RESEARCH
LA English
DT Article
DE Coffee; Tea; Anti-inflammatory properties; Atherosclerotic
   cardiovascular diseases; Chemical compounds studied in this article;
   caffeine (PubChem CID: 2519); chlorogenic acid (PubChem CID: 1794427);
   kahweol (PubChem CID: 114778); cafestol (PubChem CID: 108052); caffeic
   acid (PubChem CID: 689043); trigonelline (PubChem CID: 5570);
   epigallocatechin gallate (PubChem CID: 72277); melanoidins
ID C-REACTIVE PROTEIN; OXIDATIVE STRESS BIOMARKERS; RANDOMIZED
   CONTROLLED-TRIAL; DOSE-RESPONSE METAANALYSIS; CORONARY-HEART-DISEASE;
   GREEN TEA; METABOLIC SYNDROME; BLACK TEA; PRIMARY HYPERCHOLESTEROLEMIA;
   SYSTEMIC INFLAMMATION
AB Atherosclerotic cardiovascular disease (ASCVD) is the leading cause of premature death worldwide. Inflamma-tion and its biomarkers, like C-reactive protein (CRP), among the risk factors, such as hypertension, lipid dis-orders, and diabetes, may be also responsible for the residual cardiovascular disease (CVD) risk. Modern lipid -lowering treatment with statins, ezetimibe, PCSK9 inhibitors, or bempedoic acid does not fully protect against inflammation. The recommendations of the International Lipid Expert Panel (ILEP) indicate selected nutra-ceuticals with anti-inflammatory properties. Diet may have a significant impact on inflammation. Especially interesting in the context of inflammation is the consumption of coffee and tea. These drinks in many observational studies significantly reduced cardiovascular risk and mortality. The question is whether the anti-inflammatory effects of these drinks contribute significantly to the observed clinical effects. Thus, in this narrative review, we primarily discuss the anti-inflammatory properties of consuming tea and coffee. Based on a comprehensive analysis of the studies and their meta-analyses, inconsistent results were obtained, which makes it impossible to conclusively state how clinically significant the potential anti-inflammatory properties of black and green tea and coffee are. A number of confounding factors can cause the inconsistency of the available results. Consumption of tea and coffee appears to increase adiponectin concentrations, decrease reactive oxygen species, decrease low density lipoprotein (LDL) cholesterol concentrations (effect of green tea, etc.). Despite the still uncertain anti-inflammatory effect of tea and coffee, we recommend their consumption as a part of the healthy diet.
C1 [Surma, Stanislaw] Med Univ Silesiaia, Fac Med Sci Katowice, PL-40752 Katowice, Poland.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Biotechnol Res Ctr, Mashhad, Iran.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Appl Biomed Res Ctr, Mashhad, Iran.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Sch Pharm, Dept Biotechnol, Mashhad, Iran.
   [Banach, Maciej] Med Univ Lodz MUL, Dept Prevent Cardiol & Lipidol, PL-93338 Lodz, Poland.
   [Banach, Maciej] Univ Zielona Gora, Cardiovasc Res Ctr, PL-65417 Zielona Gora, Poland.
   [Banach, Maciej] Polish Mothers Mem Hosp Res Inst PMMHRI, Dept Cardiol & Congenital Dis Adults, PL-93338 Lodz, Poland.
C3 Medical University of Silesia; Mashhad University of Medical Sciences;
   Mashhad University of Medical Sciences; Mashhad University of Medical
   Sciences; University of Zielona Gora
RP Banach, M (corresponding author), Med Univ Lodz MUL, Dept Prevent Cardiol & Lipidol, PL-93338 Lodz, Poland.
EM surma.stanislaw96@gmail.com; amir_saheb2000@yahoo.com;
   maciej.banach@icloud.com
RI Sahebkar, Amirhossein/B-5124-2018; Surma, Stanisław/HLX-0557-2023;
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NR 196
TC 53
Z9 54
U1 1
U2 31
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 1043-6618
EI 1096-1186
J9 PHARMACOL RES
JI Pharmacol. Res.
PD JAN
PY 2023
VL 187
AR 106596
DI 10.1016/j.phrs.2022.106596
EA DEC 2022
PG 14
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 7O1DA
UT WOS:000907771000003
PM 36473629
OA hybrid
DA 2025-06-11
ER

PT J
AU Potnuri, AG
   Reddy, KP
   Suresh, P
   Husain, GM
   Kazmi, MH
   Harishankar, N
AF Potnuri, Ajay Godwin
   Reddy, Kallamadi Prathap
   Suresh, Pothani
   Husain, Gulam Mohammed
   Kazmi, Munawwar Husain
   Harishankar, Nemani
TI Obesity Potentiates the Risk of Drug-Induced Long QT
   Syndrome-Preliminary Evidence from WNIN/Ob Spontaneously Obese Rat
SO CARDIOVASCULAR TOXICOLOGY
LA English
DT Article
DE Drug-induced long QT syndrome; Electrocardiography; Haloperidol;
   Obesity; Risk factor
ID TORSADE-DE-POINTES; LEFT-VENTRICULAR HYPERTROPHY; OXIDATIVE STRESS;
   CARDIAC-HYPERTROPHY; INCREASED SUSCEPTIBILITY; ESSENTIAL-HYPERTENSION;
   INTERVAL PROLONGATION; METABOLIC SYNDROME; SUDDEN-DEATH; HEMODYNAMICS
AB Drug-induced long QT syndrome (DI-LQTS) is fatal and known to have a higher incidence in women rather than in men. Multiple risk factors potentiate the incidence of DI-LQTS, but the actual contribution of obesity remains largely unexplored. Correspondingly, the present study is aimed to evaluate the susceptibility of DI-LQTS in WNIN/Ob rat in comparison with its lean counterpart using 3-lead electrocardiography. Four- and eight-month-old female WNIN/Ob and their lean controls were used for the experimentation. Non-invasive blood pressure measurement and total body electric conductivity (TOBEC) analysis were carried out. After the baseline evaluations, animals were anesthetized with Ketamine (50 mg/kg). Haloperidol (12.5 mg/kg single dose) was administered intraperitoneally and ECG was taken at 0, 10, 20, 30, 60 min, and 24 h time points. Myocardial lystes were used to assess the BNP, protein carbonylation, and hydroxyproline content. Adiposity, as assessed by TOBEC, is higher in obese rats with elevated mean arterial blood pressure. Baseline-corrected QT interval (QTc) is significantly higher in the obese rat with a wider QRS complex. The incidence of PVC and VT are more intense in the obese rat. Haloperidol-induced QT prolongation in obese rats was rapidly induced than in lean, which was observed to remain till 24 h in obese groups while normalized in lean controls. Higher levels of BNP, protein carbonylation, hydroxyproline content, and relative heart weights indicated the presence of cardiac hypertrophy. The study provides preliminary evidence that obesity can be a potential risk factor for DI-LQTS with faster onset and longer subsistence.
C1 [Potnuri, Ajay Godwin; Suresh, Pothani] Genome Valley, ICMR Natl Anim Resource Facil Biomed Res, Dept Anim Physiol & Pharmacol, Hyderabad 500101, Andhra Pradesh, India.
   [Reddy, Kallamadi Prathap; Harishankar, Nemani] Jamai Osmania, Anim Facil, ICMR Natl Inst Nutr, Hyderabad 500007, India.
   [Husain, Gulam Mohammed; Kazmi, Munawwar Husain] Natl Res Inst Unani Medicinefor Skin Disorders, Pharmacol Res Lab, Hyderabad 500038, India.
C3 Indian Council of Medical Research (ICMR); ICMR - National Animal
   Resource Facility for Biomedical Research (NARFBR); Indian Council of
   Medical Research (ICMR); ICMR - National Institute of Nutrition (NIN)
RP Harishankar, N (corresponding author), Jamai Osmania, Anim Facil, ICMR Natl Inst Nutr, Hyderabad 500007, India.
EM hsnemani2000@yahoo.com
RI Potnuri, Ajay Godwin/ABC-1677-2021; Husain, Gulam Mohammed/B-5740-2009
OI Husain, Gulam Mohammed/0000-0002-8527-2149; KALLAMADI, PRATHAP
   REDDY/0000-0001-8910-4436
FU Indian Council for Medical Research [3/1/3/PDF (18)/2018-HRD]
FX The study is funded by Indian Council for Medical Research, [Grant No:
   3/1/3/PDF (18)/2018-HRD].
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NR 54
TC 0
Z9 0
U1 0
U2 1
PU HUMANA PRESS INC
PI TOTOWA
PA 999 RIVERVIEW DRIVE SUITE 208, TOTOWA, NJ 07512 USA
SN 1530-7905
EI 1559-0259
J9 CARDIOVASC TOXICOL
JI Cardiovasc. Toxicol.
PD OCT
PY 2021
VL 21
IS 10
BP 848
EP 858
DI 10.1007/s12012-021-09675-w
EA JUL 2021
PG 11
WC Cardiac & Cardiovascular Systems; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Toxicology
GA UJ0CI
UT WOS:000677253300001
PM 34302627
DA 2025-06-11
ER

PT J
AU Sohouli, MH
   Sharifi-Zahabi, E
   Lari, A
   Fatahi, S
   Shidfar, F
AF Sohouli, Mohammad Hassan
   Sharifi-Zahabi, Elham
   Lari, Abolfazl
   Fatahi, Somaye
   Shidfar, Farzad
TI The impact of low advanced glycation end products diet on obesity and
   related hormones: a systematic review and meta-analysis
SO SCIENTIFIC REPORTS
LA English
DT Review
ID INSULIN-RESISTANCE; OXIDATIVE STRESS; METABOLIC SYNDROME; RISK-FACTORS;
   LIFE-STYLE; INFLAMMATION; RESTRICTION; ADIPONECTIN; ENDPRODUCTS;
   IMPROVES
AB Several randomized clinical trials (RCTs) have investigated the effect of dietary advanced glycation end products (AGE) on obesity factors and related hormones in adults; results were conflicting. Therefore, a study was performed to assess the effect of low advanced glycation end products diet on obesity and related hormones. A comprehensive literature search without any limitation on language was conducted using the following bibliographical databases: Web of Science, Scopus, Ovid MEDLINE, Cochrane, and Embase up to October, 2019. From the eligible trials, 13 articles were selected for the systematic review and meta-analysis. Our systematic reviews and meta-analyses have shown a significant decrease in BMI (WMD: -0.3 kg/m(2); 95% CI: -0.52, -0.09, p=0.005; I-2=55.8%), weight (WMD: -0.83 kg; 95% CI: -1.55, -0.10, p=0.026; I-2=67.0%), and leptin (WMD: -19.85 ng/ml; 95% CI: -29.88, -9.82, p<0.001; I-2=81.8%) and an increase in adiponectin (WMD: 5.50 <mu>g/ml; 95% CI: 1.33, 9.67, p=0.010; I-2=90.6%) levels after consumption of the low AGE diets compared to the high AGE diets. Also, the effect of intake of low AGE compared to high AGE diets was more pronounced in subgroup with duration>8 weeks for the BMI and weight. Overall, according to our results, although low AGE diets appeared to be statistically significant in reducing the prevalence of obesity and chronic diseases compared to high consumption of dietary AGEs. But, no clinical significance was observed. Therefore, to confirm these results clinically, further prospective studies should be conducted in this regard. The study protocol was registered in the in International prospective register of systematic reviews (PROSPERO) database as CRD42020203734.
C1 [Sohouli, Mohammad Hassan; Sharifi-Zahabi, Elham; Lari, Abolfazl; Fatahi, Somaye; Shidfar, Farzad] Iran Univ Med Sci, Fac Publ Hlth Branch, Student Res Comm, Tehran, Iran.
   [Sohouli, Mohammad Hassan; Sharifi-Zahabi, Elham; Lari, Abolfazl; Fatahi, Somaye] Iran Univ Med Sci, Sch Publ Hlth, Dept Nutr, Hemmat Superhighway, Tehran, Iran.
   [Shidfar, Farzad] Iran Univ Med Sci, Pediat Growth & Dev Res Ctr, Tehran, Iran.
C3 Iran University of Medical Sciences; Iran University of Medical
   Sciences; Iran University of Medical Sciences
RP Shidfar, F (corresponding author), Iran Univ Med Sci, Fac Publ Hlth Branch, Student Res Comm, Tehran, Iran.; Shidfar, F (corresponding author), Iran Univ Med Sci, Pediat Growth & Dev Res Ctr, Tehran, Iran.
EM shidfar.f@iums.ac.ir
RI Shidfar, Farzad/H-6651-2018
FU Iran University of Medical Sciences, Tehran, Iran
FX This review was supported by Iran University of Medical Sciences,
   Tehran, Iran
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NR 50
TC 20
Z9 20
U1 1
U2 9
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD DEC 17
PY 2020
VL 10
IS 1
AR 22194
DI 10.1038/s41598-020-79216-y
PG 11
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA PL6WA
UT WOS:000603258300003
PM 33335235
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Tabrizi, R
   Ostadmohammadi, V
   Lankarani, KB
   Akbari, M
   Akbari, H
   vakili, S
   Shokrpour, M
   Kolandooz, F
   Rouhi, V
   Asemi, Z
AF Tabrizi, Reza
   Ostadmohammadi, Vahidreza
   Lankarani, Kamran B.
   Akbari, Maryam
   Akbari, Hamideh
   vakili, Sina
   Shokrpour, Maryam
   Kolandooz, Fariba
   Rouhi, Vajihe
   Asemi, Zatollah
TI The effects of probiotic and synbiotic supplementation on inflammatory
   markers among patients with diabetes: A systematic review and
   meta-analysis of randomized controlled trials
SO EUROPEAN JOURNAL OF PHARMACOLOGY
LA English
DT Review
DE Probiotic; Synbiotic; Inflammatory markers; Diabetes; Meta-analysis
ID C-REACTIVE PROTEIN; DOUBLE-BLIND; LIPID PROFILE; CARDIOVASCULAR-DISEASE;
   METABOLIC SYNDROME; OXIDATIVE STRESS; GLYCEMIC CONTROL; TYPE-2;
   MELLITUS; CONSUMPTION
AB This systematic review and meta-analysis of randomized controlled trials (RCTs) was performed to evaluate the effect of probiotic and symbiotic supplementation on inflammatory markers among patients with diabetes. Clinical trials were searched using Cochrane Library, EMBASE, PubMed, and Web of Science online databases for relevant trials published until April 2018. Two independent investigators evaluated study eligibility, extracted data, and assessed risk of bias of included clinical trials. Cochran's Q test and I-square (I-2) statistic were used to detect heterogeneity among the included. Data were pooled by using the random-effect model and standardized mean difference (SMD) was considered as the summary effect size. From 986 originally identified publications 18 clinical trials with a total of 1337 patients were included. Findings showed that probiotic and synbiotic supplementation among patients with diabetes significantly decreased tumor necrosis factor-alpha (TNF-alpha) (SMD = -2.99; 95% CI, -4.77, -1.20; P = 0.001; I-2 : 96.3), and C-reactive protein (CRP) (SMD = -0.87; 95% CI, -1.27, -0.48; P < 0.001; I-2 : 90.2); while significantly increased nitric oxide (NO) concentrations (SMD = 1.49; 95% CI, 0.81, 2.16; P < 0.001; I-2 : 92.1). There were no effects of probiotic and synbiotic supplementation on interleukin-6 (IL-6) levels (SMD = -0.65; 95% CI, -1.88, 0.59; P = 0.30; I-2 : 94.7). In summary, the current meta-analysis demonstrated probiotic and synbiotic supplementation among patients with diabetes significantly decreased CRP and TNF-alpha, and increased NO levels, but did not affect IL-6 levels.
C1 [Tabrizi, Reza; Akbari, Maryam] Shiraz Univ Med Sci, Hlth Policy Res Ctr, Inst Hlth, Student Res Comm, Shiraz, Iran.
   [Ostadmohammadi, Vahidreza; Rouhi, Vajihe; Asemi, Zatollah] Kashan Univ Med Sci, Res Ctr Biochem & Nutr Metab Dis, Kashan, Iran.
   [Lankarani, Kamran B.] Shiraz Univ Med Sci, Hlth Policy Res Ctr, Inst Hlth, Shiraz, Iran.
   [Akbari, Hamideh] Golestan Univ Med Sci, Sch Med, Dept Internal Med, Gorgan, Golestan, Iran.
   [vakili, Sina] Shiraz Univ Med Sci, Dept Biochem, Shiraz, Iran.
   [Shokrpour, Maryam] Arak Univ Med Sci, Sch Med, Dept Gynecol & Obstet, Arak, Iran.
   [Kolandooz, Fariba] Univ Alberta, Dept Med, Indigenous & Global Hlth Res, Edmonton, AB, Canada.
C3 Shiraz University of Medical Science; Shiraz University of Medical
   Science; Golestan University of Medical Sciences; Shiraz University of
   Medical Science; University of Alberta
RP Asemi, Z (corresponding author), Kashan Univ Med Sci, Res Ctr Biochem & Nutr Metab Dis, Kashan, Iran.; Shokrpour, M (corresponding author), Arak Univ Med Sci, Sch Med, Dept Gynecol & Obstet, Arak, Iran.
EM drshokrpour@gmail.com; asemi_r@yahoo.com
RI lankarani, kamran/D-5901-2012; Vakili, Sina/AAW-5684-2021; Shokrpour,
   Maryam/A-7234-2018; Akbari, Hamed/B-5923-2018; Akbari, Ali/G-6044-2016;
   Asemi, Zatollah/G-7393-2017; Ostadmohammadi, Vahidreza/A-6248-2018
OI Akbari, Hamide/0000-0003-4880-6495; Vakili, Sina/0000-0002-5472-8350;
   Ostadmohammadi, Vahidreza/0000-0002-4633-5397; tabrizi,
   reza/0000-0001-7634-3948
FU Shiraz University of Medical Sciences
FX The research grant provided by Research Deputy of Shiraz University of
   Medical Sciences.
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NR 51
TC 36
Z9 37
U1 0
U2 34
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0014-2999
EI 1879-0712
J9 EUR J PHARMACOL
JI Eur. J. Pharmacol.
PD JUN 5
PY 2019
VL 852
BP 254
EP 264
DI 10.1016/j.ejphar.2019.04.003
PG 11
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA HU0ST
UT WOS:000464982100026
PM 30959049
DA 2025-06-11
ER

PT J
AU Méndez-Lara, KA
   Farré, N
   Santos, D
   Rivas-Urbina, A
   Metso, J
   Sánchez-Quesada, JL
   Llorente-Cortes, V
   Errico, TL
   Lerma, E
   Jauhiainen, M
   Martín-Campos, JM
   Alonso, N
   Escolà-Gil, JC
   Blanco-Vaca, F
   Julve, J
AF Alejandra Mendez-Lara, Karen
   Farre, Nuria
   Santos, David
   Rivas-Urbina, Andrea
   Metso, Jari
   Luis Sanchez-Quesada, Jose
   Llorente-Cortes, Vicenta
   Errico, Teresa L.
   Lerma, Enrique
   Jauhiainen, Matti
   Martin-Campos, Jesus M.
   Alonso, Nuria
   Carles Escola-Gil, Joan
   Blanco-Vaca, Francisco
   Julve, Josep
TI Human ApoA-I Overexpression Enhances Macrophage-Specific Reverse
   Cholesterol Transport but Fails to Prevent Inherited Diabesity in Mice
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE HDL functions; reverse cholesterol transport; metabolic syndrome;
   obesity; hepatic steatosis
ID APOLIPOPROTEIN-A-I; HIGH-DENSITY-LIPOPROTEIN; ENDOPLASMIC-RETICULUM
   STRESS; ABCG8 STEROL TRANSPORTER; FATTY LIVER-DISEASE; HEPATIC
   STEATOSIS; PPAR-GAMMA; INSULIN SENSITIVITY; LIPID-ACCUMULATION;
   DOWN-REGULATION
AB Human apolipoprotein A-I (hApoA-I) overexpression improves high-density lipoprotein (HDL) function and the metabolic complications of obesity. We used a mouse model of diabesity, the db/db mouse, to examine the effects of hApoA-I on the two main functional properties of HDL, i.e., macrophage-specific reverse cholesterol transport (m-RCT) in vivo and the antioxidant potential, as well as the phenotypic features of obesity. HApoA-I transgenic (hA-I) mice were bred with nonobese control (db/+) mice to generate hApoA-I-overexpressing db/+ offspring, which were subsequently bred to obtain hA-I-db/db mice. Overexpression of hApoA-I significantly increased weight gain and the incidence of fatty liver in db/db mice. Weight gain was mainly explained by the increased caloric intake of hA-I-db/db mice (>1.2-fold). Overexpression of hApoA-I also produced a mixed type of dyslipidemia in db/db mice. Despite these deleterious effects, the overexpression of hApoA-I partially restored m-RCT in db/db mice to levels similar to nonobese control mice. Moreover, HDL from hA-I-db/db mice also enhanced the protection against low-density lipoprotein (LDL) oxidation compared with HDL from db/db mice. In conclusion, overexpression of hApoA-I in db/db mice enhanced two main anti-atherogenic HDL properties while exacerbating weight gain and the fatty liver phenotype. These adverse metabolic side-effects were also observed in obese mice subjected to long-term HDL-based therapies in independent studies and might raise concerns regarding the use of hApoA-I-mediated therapy in obese humans.
C1 [Alejandra Mendez-Lara, Karen; Farre, Nuria; Rivas-Urbina, Andrea; Luis Sanchez-Quesada, Jose; Errico, Teresa L.; Martin-Campos, Jesus M.; Carles Escola-Gil, Joan; Julve, Josep] IIB St Pau, Inst Recerca Hosp Santa Creu & St Pau, Barcelona 08025, Spain.
   [Alejandra Mendez-Lara, Karen; Farre, Nuria; Rivas-Urbina, Andrea; Luis Sanchez-Quesada, Jose; Errico, Teresa L.; Martin-Campos, Jesus M.; Carles Escola-Gil, Joan; Julve, Josep] IIB St Pau, Inst Invest Biomed St Pau, Barcelona 08025, Spain.
   [Alejandra Mendez-Lara, Karen; Rivas-Urbina, Andrea; Luis Sanchez-Quesada, Jose; Errico, Teresa L.; Martin-Campos, Jesus M.; Carles Escola-Gil, Joan; Blanco-Vaca, Francisco; Julve, Josep] Univ Autonoma Barcelona, Dept Bioquim & Biol Mol, E-08193 Barcelona, Spain.
   [Santos, David; Luis Sanchez-Quesada, Jose; Errico, Teresa L.; Martin-Campos, Jesus M.; Alonso, Nuria; Carles Escola-Gil, Joan; Blanco-Vaca, Francisco; Julve, Josep] CIBERDEM, CIBER Diabet & Enfermedades Metabol Asociadas, Madrid 28029, Spain.
   [Metso, Jari; Jauhiainen, Matti] Biomedicum 2U, Minerva Fdn Inst Med Res, FIN-00290 Helsinki, Finland.
   [Metso, Jari; Jauhiainen, Matti] Natl Inst Hlth & Welf, Genom & Biomarkers Unit, FIN-00290 Helsinki, Finland.
   [Llorente-Cortes, Vicenta] IIB St Pau, ICCC, CSIC, Barcelona 08025, Spain.
   [Llorente-Cortes, Vicenta] CSIC, Inst Invest Biomed Barcelona IIBB, Barcelona 08025, Spain.
   [Llorente-Cortes, Vicenta] CIBERCV, CIBER Enfermedades Cardiovasc, Madrid 28029, Spain.
   [Lerma, Enrique; Blanco-Vaca, Francisco] IIB St Pau, Hosp Santa Creu & St Pau, Servei Bioquim, Barcelona 08041, Spain.
   [Lerma, Enrique; Blanco-Vaca, Francisco] IIB St Pau, Hosp Santa Creu & St Pau, Inst Invest Biomed, Barcelona 08041, Spain.
   [Lerma, Enrique] Hosp Santa Creu & Sant Pau, Dept Patol, Barcelona 08041, Spain.
   [Lerma, Enrique] Univ Autonoma Barcelona, Dept Ciencies Morfol, Bellaterra 08193, Spain.
   [Alonso, Nuria] Hosp Badalona Germans Trias & Pujol, Servei Endocrinol, Barcelona 08916, Spain.
C3 Hospital of Santa Creu i Sant Pau; Autonomous University of Barcelona;
   CIBER - Centro de Investigacion Biomedica en Red; CIBERDEM; Finland
   National Institute for Health & Welfare; Consejo Superior de
   Investigaciones Cientificas (CSIC); CSIC - Institut Catala de Ciencies
   Cardiovasculars (ICCC); Consejo Superior de Investigaciones Cientificas
   (CSIC); CSIC - Instituto de Investigaciones Biomedicas de Barcelona
   (IIBB); CIBER - Centro de Investigacion Biomedica en Red; CIBERCV;
   Hospital of Santa Creu i Sant Pau; Hospital of Santa Creu i Sant Pau;
   Hospital of Santa Creu i Sant Pau; Autonomous University of Barcelona;
   Hospital Germans Trias i Pujol
RP Blanco-Vaca, F; Julve, J (corresponding author), IIB St Pau, Inst Recerca Hosp Santa Creu & St Pau, Barcelona 08025, Spain.; Julve, J (corresponding author), IIB St Pau, Inst Invest Biomed St Pau, Barcelona 08025, Spain.; Blanco-Vaca, F; Julve, J (corresponding author), Univ Autonoma Barcelona, Dept Bioquim & Biol Mol, E-08193 Barcelona, Spain.; Blanco-Vaca, F; Julve, J (corresponding author), CIBERDEM, CIBER Diabet & Enfermedades Metabol Asociadas, Madrid 28029, Spain.; Blanco-Vaca, F (corresponding author), IIB St Pau, Hosp Santa Creu & St Pau, Servei Bioquim, Barcelona 08041, Spain.
EM kmendez@santpau.cat; nfarrec@santpau.cat; daymer11@hotmail.com;
   arivas@santpau.cat; jari.metso@thl.fi; jsanchezq@santpau.cat;
   cllorente@santpau.cat; terrico@santpau.cat; elerma@santpau.cat;
   matti.jauhiainen@thl.fi; jmartinca@santpau.cat; nalonso32416@yahoo.es;
   jescola@santpau.cat; fblancova@santpau.cat; jjulve@santpau.cat
RI Mendez Lara, Karen/GZH-2511-2022; Escolà-Gil, Joan Carles/H-9522-2014;
   Blanco-Vaca, Francisco/AAC-2600-2022; Martín-Campos, Jesús
   M./AAQ-5478-2021; Lerma, Enrique/C-8498-2015; Llorente Cortes,
   Concepcion Vicenta/KDN-5588-2024; Mendez Lara, Karen
   Alejandra/Q-1750-2017; Julve, Josep/I-1003-2017; Alonso Pedrol,
   Nuria/AAA-8987-2021
OI Alonso, Nuria/0000-0001-5844-2221; Mendez Lara, Karen
   Alejandra/0000-0002-8372-2310; Jauhiainen, Matti/0000-0002-3836-3785;
   Escola-Gil, Joan Carles/0000-0001-9021-2485; Blanco-Vaca,
   Francisco/0000-0001-7380-5385; Santos, David/0000-0003-1157-4969; Julve,
   Josep/0000-0002-6531-2246; Martin-Campos, Jesus
   Maria/0000-0003-0414-037X; Llorente Cortes, Concepcion
   Vicenta/0000-0002-0067-7201; Rivas-Urbina, Andrea/0000-0002-0111-0477;
   Alonso Pedrol, Nuria/0000-0001-9687-8050
FU Ministerio de Sanidad y Consumo, Instituto de Salud Carlos III (ISCIII)
   FIS [CP13/00070, PI17-00232, PI11/01076, PI17-01362, PI16/00139,
   PI16/00471]; FEDER "Una manera de hacer Europa"; Institut de Recerca de
   l'Hospital de la Santa Creu i Sant Pau [IR17-MS7]; La Marato de TV3 2016
   [201602.30.31]; Miguel Servet Type 1 contract [CP13/00070]; FIS
   [PI12-0226]; AGAUR [FI-DGR2014]
FX This work was partially funded by the Ministerio de Sanidad y Consumo,
   Instituto de Salud Carlos III (ISCIII) FIS grants CP13/00070, PI17-00232
   (to J. J.), PI11/01076 (to F.B.-V.), PI17-01362 (to N.A-P.), PI16/00139
   (to J.C.E.-G.), and PI16/00471 (to J.L.S.-Q.), the FEDER "Una manera de
   hacer Europa", intramural project of the Institut de Recerca de
   l'Hospital de la Santa Creu i Sant Pau (IR17-MS7), and La Marato de TV3
   2016 (201602.30.31) (to N.A.-P. and J.J.). J.J. was a recipient of a
   Miguel Servet Type 1 contract (CP13/00070; ISCIII). T.L.E. was a
   recipient of an FIS grant contract PI12-0226 (ISCIII). K.A.M.-L. was a
   recipient of an AGAUR grant FI-DGR2014 (Generalitat de Catalunya). CIBER
   de Diabetes y Enfermedades Metabolicas Asociadas (CIBERDEM) and CIBER de
   Enfermedades Cardiovasculares (CIBERCV) are projects of the Instituto de
   Salud Carlos III.
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NR 62
TC 8
Z9 8
U1 0
U2 6
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD FEB 1
PY 2019
VL 20
IS 3
AR 655
DI 10.3390/ijms20030655
PG 18
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA HQ4WR
UT WOS:000462412500199
PM 30717414
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Turchinovich, A
   Baranova, A
   Drapkina, O
   Tonevitsky, A
AF Turchinovich, Andrey
   Baranova, Ancha
   Drapkina, Oksana
   Tonevitsky, Alexander
TI Cell-Free Circulating Nucleic Acids as Early Biomarkers for NAFLD and
   NAFLD-Associated Disorders
SO FRONTIERS IN PHYSIOLOGY
LA English
DT Review
DE cell-free RNA; NAFLD; early diagnosis; extracellular nucleic acids;
   circulating microRNA; liver diseases; liquid biopsy; non-coding RNA
ID FATTY LIVER-DISEASE; TERM-FOLLOW-UP; HEPATOCELLULAR-CARCINOMA;
   NONALCOHOLIC STEATOHEPATITIS; UNITED-STATES; EXTRACELLULAR MICRORNA;
   CARDIOVASCULAR-DISEASE; DIAGNOSTIC MARKER; RISK-FACTORS; WEIGHT-LOSS
AB Non-alcoholic fatty liver disease (NAFLD) is the worldwide most common cause of chronic liver pathology, which prevalence strongly correlates with the increasing incidence of diabetes, obesity and metabolic syndrome in the general population. Simple steatosis, the earliest NAFLD stage, usually remains asymptomatic, and appropriate changes in the lifestyle, as well as the diet, can reverse the affected liver into the healthy state. The potential of simple steatosis to progress into severe fibrotic stages and to facilitate carcinogenesis necessitates timely NAFLD detection and risk stratification in community-based healthcare settings. Since their initial discovery a decade ago, extracellular circulating miRNAs have been found in all human biological fluids including blood and shown to hold great promises as non-invasive biomarkers. Normally, intracellular miRNAs participate in the regulation of gene expression, but once released by dying/dead cells they remain highly stable in the extracellular environment for prolonged periods. Therefore, circulating miRNA profiles can reflect the ongoing pathogenic processes in body's tissues and organs, and enable highly sensitive non-invasive diagnosis of multiple disorders. A non-urgent character of the NAFLD-related decision-making justifies the use of chronic liver diseases as an excellent test case for examining the practical utility of circulating miRNAs as biomarkers for longitudinal monitoring of human health. In this review, we summarize the state-of-the-art in the field of early diagnosis of NAFLD using circulating blood miRNAs, and stress the necessity of additional experimental validation of their diagnostic potential. We further emphasize on the potential diagnostics promises of other cell-free RNA species found in human biological fluids.
C1 [Turchinovich, Andrey] SciBerg E Kfm, Mannheim, Germany.
   [Turchinovich, Andrey] German Canc Res Ctr, Mol Epidemiol C080, Heidelberg, Germany.
   [Baranova, Ancha] George Mason Univ, Sch Syst Biol, Fairfax, VA 22030 USA.
   [Baranova, Ancha] Res Ctr Med Genet, Moscow, Russia.
   [Baranova, Ancha] Atlas Biomed Grp, Moscow, Russia.
   [Drapkina, Oksana] Fed State Inst Natl Res Ctr Prevent Med, Moscow, Russia.
   [Tonevitsky, Alexander] Higher Sch Econ, Dept Cell Biol, Moscow, Russia.
   [Tonevitsky, Alexander] Art Photon GmbH, Berlin, Germany.
   [Tonevitsky, Alexander] SRC Bioclin, Moscow, Russia.
C3 Helmholtz Association; German Cancer Research Center (DKFZ); George
   Mason University; Research Centre for Medical Genetics; National Medical
   Research Center for Therapy & Preventive Medicine; HSE University
   (National Research University Higher School of Economics)
RP Turchinovich, A (corresponding author), SciBerg E Kfm, Mannheim, Germany.; Turchinovich, A (corresponding author), German Canc Res Ctr, Mol Epidemiol C080, Heidelberg, Germany.
EM andrey.turchinovich@sciberg.com
RI turchinovich, andrey/B-2700-2014; Tonevitsky, Alexander/R-5596-2019;
   Baranova, Ancha/B-4608-2012; Drapkina, Oksana/G-8443-2016
OI Baranova, Ancha/0000-0001-6810-5982; Turchinovich,
   Andrey/0000-0003-4153-0895; Drapkina, Oksana/0000-0002-4453-8430
FU Russian Science Foundation [17-14-01338]; Russian Science Foundation
   [17-14-01338] Funding Source: Russian Science Foundation
FX The study was partially funded by the Russian Science Foundation
   (project 17-14-01338).
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NR 133
TC 24
Z9 26
U1 2
U2 15
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1664-042X
J9 FRONT PHYSIOL
JI Front. Physiol.
PD SEP 20
PY 2018
VL 9
AR 1256
DI 10.3389/fphys.2018.01256
PG 13
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA GU2RQ
UT WOS:000445118100001
PM 30294278
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Sedaghat, S
   van Sloten, TT
   Laurent, S
   London, GM
   Pannier, B
   Kavousi, M
   Mattace-Raso, F
   Franco, OH
   Boutouyrie, P
   Ikram, MA
   Stehouwer, CDA
AF Sedaghat, Sanaz
   van Sloten, Thomas T.
   Laurent, Stephane
   London, Gerard M.
   Pannier, Bruno
   Kavousi, Maryam
   Mattace-Raso, Francesco
   Franco, Oscar H.
   Boutouyrie, Pierre
   Ikram, M. Arfan
   Stehouwer, Coen D. A.
TI Common Carotid Artery Diameter and Risk of Cardiovascular Events and
   Mortality: Pooled Analyses of Four Cohort Studies
SO HYPERTENSION
LA English
DT Article
DE atherosclerosis; carotid artery, common; cohort studies; mortality;
   risk; stroke
ID INTIMA-MEDIA THICKNESS; LOCAL PULSE PRESSURE; ALL-CAUSE MORTALITY;
   METABOLIC SYNDROME; GLUCOSE-TOLERANCE; INCIDENT STROKE; BLOOD-PRESSURE;
   RECENT HISTORY; STIFFNESS; ATHEROSCLEROSIS
AB Carotid arterial diameter enlargement is a manifestation of arterial remodeling and may be a risk factor for cardiovascular disease (CVD). We evaluated the association between carotid artery diameter and risk of stroke, coronary heart disease, CVD, and all-cause mortality and explored whether the associations could be explained by processes involved in arterial remodeling, that is, blood pressure-related media thickening, arterial stiffness, arterial wall stress, and atherosclerosis. We included 4887 participants (mean age 67 +/- 9 years; 54% women) from 4 cohort studies: Rotterdam Study, NEPHROTEST, Hoorn Study, and a study by Blacher et al. Common carotid artery properties were measured using echotracking. Incident cases were recorded based on medical records. We used Cox proportional hazard models adjusting for cardiovascular risk factors and estimates of processes underlying arterial remodeling. During follow-up (mean, 11 years), 379 (8%) individuals had a stroke, 516 had a (11%) coronary heart disease, 807 had a (17%) CVD, and 1486 (30%) had died. After adjustment for cardiovascular risk factors, individuals in the highest tertile of carotid diameter (diameter >8 mm) compared with those in the lowest tertile (diameter <7 mm) had a higher incidence of stroke (hazard ratio, 1.5; 95% confidence interval, 1.1-2.0). From all estimates of processes underlying arterial remodeling, adjustment for carotid intima-media thickness attenuated this association (hazard ratio after adjustment for intima-media thickness, 1.2; 95% confidence interval, 0.9-1.6). Larger carotid diameter was associated with risk of CVD and mortality but not clearly with coronary heart disease risk. We showed that a larger carotid diameter is associated with incident stroke, CVD, and mortality. Carotid intima-media thickness, a measure of blood pressure-related media thickening, partially explained the association with stroke incidence.
C1 [Sedaghat, Sanaz; Kavousi, Maryam; Franco, Oscar H.; Ikram, M. Arfan] Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands.
   [Mattace-Raso, Francesco] Erasmus MC, Dept Internal Med, Rotterdam, Netherlands.
   [Ikram, M. Arfan] Erasmus MC, Dept Neurol, Rotterdam, Netherlands.
   [Ikram, M. Arfan] Erasmus MC, Dept Radiol, Rotterdam, Netherlands.
   [van Sloten, Thomas T.; Stehouwer, Coen D. A.] Maastricht Univ, Med Ctr, Dept Internal Med, Prof Debyelaan 25, NL-6229 HX Maastricht, Netherlands.
   [van Sloten, Thomas T.; Stehouwer, Coen D. A.] Maastricht Univ, Med Ctr, Cardiovasc Res Inst Maastricht, Maastricht, Netherlands.
   [van Sloten, Thomas T.; Laurent, Stephane; Boutouyrie, Pierre] Univ Paris 05, HEGP, AP HP, Inserm U970, Paris, France.
   [Laurent, Stephane; Boutouyrie, Pierre] Georges Pompidou European Hosp, Dept Pharmacol, Paris, France.
   [London, Gerard M.] Hop Manhes, Dept Nephrol, Paris, France.
   [Pannier, Bruno] Ctr Invest Prevent & Clin IPC Ctr, Paris, France.
C3 Erasmus University Rotterdam; Erasmus MC; Erasmus University Rotterdam;
   Erasmus MC; Erasmus University Rotterdam; Erasmus MC; Erasmus University
   Rotterdam; Erasmus MC; Maastricht University; Maastricht University;
   Universite Paris Cite; Institut National de la Sante et de la Recherche
   Medicale (Inserm); Assistance Publique Hopitaux Paris (APHP); Hopital
   Universitaire Europeen Georges-Pompidou - APHP; Assistance Publique
   Hopitaux Paris (APHP); Universite Paris Cite; Hopital Universitaire
   Europeen Georges-Pompidou - APHP
RP Stehouwer, CDA (corresponding author), Maastricht Univ, Med Ctr, Dept Internal Med, Prof Debyelaan 25, NL-6229 HX Maastricht, Netherlands.
EM cda.stehouwer@mumc.nl
RI Stehouwer, Coen/AAB-3435-2021; Franco, Óscar/ABE-2305-2020; Ikram,
   M./AAM-5225-2021; boutouyrie, pierre/HGT-8201-2022; Kavousi,
   Maryam/F-1174-2018; Raso, Francesco/L-2541-2015; Boutouyrie,
   Pierre/J-8592-2015
OI Ikram, Mohammad Arfan/0000-0003-0372-8585; Franco,
   Oscar/0000-0002-4606-4929; Kavousi, Maryam/0000-0001-5976-6519;
   Boutouyrie, Pierre/0000-0002-4375-3569; Mattace-Raso,
   Francesco/0000-0002-1688-6497; van Sloten, Thomas/0000-0003-2870-482X;
   Stehouwer, Coen/0000-0001-8752-3223; Sedaghat, Sanaz/0000-0002-8296-1811
FU European Regional Development Fund as part of OP-ZUID; province of
   Limburg; Department of Economic Affairs of the Netherlands [31O.041];
   Stichting the Weijerhorst; Pearl String Initiative Diabetes;
   Cardiovascular Centre Maastricht; Cardiovascular Research Institute
   Maastricht; School for Nutrition, Toxicology and Metabolism; Stichting
   Annadal; Health Foundation Limburg; VENI grant from The Netherlands
   Organization for Health Research and Development (ZonMw) [91616079];
   Nestle Nutrition (Nestec, Ltd); Metagenics, Inc; AXA; Assistance
   Publique Hopitaux de Paris; Paris Descartes University; National
   Institute for Health and Medical Research (INSERM); Netherlands
   Organization for Health Research and Development; Netherlands Heart
   Foundation; Dutch Diabetes Foundation; Programme Hospitalier de
   Recherche Clinique, French Ministry of Health; INSERM; Erasmus MC;
   Erasmus University Rotterdam; Netherlands Organisation for Scientific
   Research; ZonMw; Research Institute for Diseases in the Elderly;
   Netherlands Genomics Initiative; Ministry of Education, Culture and
   Science; Ministry of Health Welfare and Sports; European Commission (DG
   XII); Municipality of Rotterdam
FX T. Van Sloten and C.D.A. Stehouwer are supported by the European
   Regional Development Fund as part of OP-ZUID, the province of Limburg,
   the Department of Economic Affairs of the Netherlands (grant 31O.041),
   Stichting the Weijerhorst, the Pearl String Initiative Diabetes, the
   Cardiovascular Centre Maastricht, Cardiovascular Research Institute
   Maastricht, School for Nutrition, Toxicology and Metabolism, Stichting
   Annadal, and Health Foundation Limburg. M. Kavousi is supported by the
   VENI grant (91616079) from The Netherlands Organization for Health
   Research and Development (ZonMw). O.H. Franco works in ErasmusAGE, a
   center for aging research across the life course funded by Nestle
   Nutrition (Nestec, Ltd); Metagenics, Inc; and AXA. S. Laurent, G.M.
   London, B. Pannier, and P. Boutouyrie are supported by Assistance
   Publique Hopitaux de Paris, Paris Descartes University, and National
   Institute for Health and Medical Research (INSERM). The Hoorn Study was
   supported by grants from the Netherlands Organization for Health
   Research and Development, the Netherlands Heart Foundation, and the
   Dutch Diabetes Foundation. The NEPHROTEST study was supported by grants
   from Programme Hospitalier de Recherche Clinique, French Ministry of
   Health; and INSERM. The Rotterdam Study is supported by the Erasmus MC,
   and Erasmus University Rotterdam; the Netherlands Organisation for
   Scientific Research; the ZonMw; the Research Institute for Diseases in
   the Elderly; the Netherlands Genomics Initiative; the Ministry of
   Education, Culture and Science; the Ministry of Health Welfare and
   Sports; the European Commission (DG XII); and the Municipality of
   Rotterdam.
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NR 32
TC 45
Z9 49
U1 1
U2 9
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0194-911X
EI 1524-4563
J9 HYPERTENSION
JI Hypertension
PD JUL
PY 2018
VL 72
IS 1
BP 85
EP 92
DI 10.1161/HYPERTENSIONAHA.118.11253
PG 8
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA GJ2NL
UT WOS:000435107800017
PM 29785959
OA Green Published
DA 2025-06-11
ER

PT J
AU Boix-Castejón, M
   Herranz-López, M
   Gago, AP
   Olivares-Vicente, M
   Caturla, N
   Roche, E
   Micol, V
AF Boix-Castejon, Marina
   Herranz-Lopez, Maria
   Perez Gago, Alberto
   Olivares-Vicente, Marilo
   Caturla, Nuria
   Roche, Enrique
   Micol, Vicente
TI Hibiscus and lemon verbena polyphenols modulate appetite-related
   biomarkers in overweight subjects: a randomized controlled trial
SO FOOD & FUNCTION
LA English
DT Article
ID PLANT-DERIVED POLYPHENOLS; LONG-TERM PERSISTENCE; PLASMA GHRELIN LEVELS;
   OXIDATIVE STRESS; ENERGY-BALANCE; WEIGHT-LOSS; DIETARY POLYPHENOLS;
   METABOLIC SYNDROME; LIPPIA-CITRIODORA; AQUEOUS EXTRACT
AB Trial design: Plant-derived polyphenols have shown potential to alleviate obesity-related pathologies by a multi-targeted mechanism in animal models and human intervention studies. A dietary supplement based on a combination of Lippia citriodora (LC) and Hibiscus sabdariffa (HS) polyphenolic extracts was assayed in a double blind and placebo-controlled intervention study with 54 overweight subjects. Methods: Blood pressure, body weight, height, triceps, biceps and abdominal skinfold thickness, and arm and abdominal circumferences were taken at the baseline, 30 and 60 days of the intervention period. The validated Visual Analogue Scale used to record hunger and satiety-related sensations was passed at the beginning and at 15, 30, 45 and 60 days of the intervention. Subjective health status was assessed through the validated SF-36 questionnaire at the beginning and end of the study. Finally, plasma from fasting blood samples was obtained at the beginning, 30 and 60 days of the study. Results: The results showed an improvement of anthropometric measurements, decreased blood pressure and heart rate and a more positive perception in the overall health status. We also observed that plant polyphenols increased anorexigenic hormones (glucagon-like peptide-1) and decreased orexigenic hormones (ghrelin). Conclusions: Based on previous evidence we postulate that AMP-activated protein kinase may have a role in such effects through its capability to modulate energy homeostasis, total daily energy expenditure and lipid management. Although further research may be required, we propose that this polyphenolic combination may be used for weight management by increasing long-term weight loss maintenance through the modulation of appetite biomarkers. This may help to avoid the undesired weight regain typical of calorie restriction diets.
C1 [Boix-Castejon, Marina; Perez Gago, Alberto; Roche, Enrique] Miguel Hernandez Univ, ISABIAL FISABIO Fdn, Alicante Inst Hlth & Biomed Res, Dept Appl Biol Nutr, Alicante, Spain.
   [Herranz-Lopez, Maria; Olivares-Vicente, Marilo; Micol, Vicente] UMH, IBMC, Alicante, Spain.
   [Caturla, Nuria] Monteloeder SL, Alicante, Spain.
   [Roche, Enrique; Micol, Vicente] Inst Salud Carlos III CB12 03 30038, CIBERobn, CIBER, Fisiopatol Obesidad & Nutr, Madrid, Spain.
C3 General University Hospital of Alicante; Universidad Miguel Hernandez de
   Elche; Universitat d'Alacant; Instituto de Investigacion Sanitaria y
   Biomedica de Alicante (ISABIAL); Universidad Miguel Hernandez de Elche;
   CIBER - Centro de Investigacion Biomedica en Red; CIBEROBN
RP Herranz-López, M (corresponding author), UMH, IBMC, Alicante, Spain.
EM mherranz@umh.es
RI Herranz-Lopez, Maria/AAB-1933-2020; Micol, Vicente/K-6841-2014; Roche,
   Enrique/V-5738-2017
OI Micol, Vicente/0000-0001-8089-0696; Caturla, Nuria/0000-0003-3464-0594;
   Olivares-Vicente, Marilo/0000-0002-2792-9181; Herranz-Lopez,
   Maria/0000-0002-1819-7978; Roche, Enrique/0000-0001-5128-1672
FU Spanish Ministry of Science and Innovation [AGL2011-29857-C03-03];
   Spanish Ministry of Economy and Competitiveness (MINECO)
   [AGL2015-67995-C3-1-R, PTQ-14-07243]; Generalitat Valenciana
   [PROMETEO/2012/007, PROMETEO/2016/006, ACIF/2013/064, ACIF/2016/230];
   CIBER (Fisiopatologia de la Obesidad y la Nutricion, CIBERobn, Instituto
   de Salud Carlos III, Spain) [CB12/03/30038]; Spanish Centre for the
   Development of Industrial Technology (CDTI, MINECO) [IDI-20150608];
   H2020 SME Phase II project [783838]; H2020 - Industrial Leadership
   [783838] Funding Source: H2020 - Industrial Leadership
FX This work has been funded by the following grants: AGL2011-29857-C03-03
   from the Spanish Ministry of Science and Innovation; Grant
   AGL2015-67995-C3-1-R and PTQ-14-07243 from the Spanish Ministry of
   Economy and Competitiveness (MINECO); PROMETEO/2012/007,
   PROMETEO/2016/006, ACIF/2013/064 and ACIF/2016/230 from Generalitat
   Valenciana; and CB12/03/30038 grant from CIBER (Fisiopatologia de la
   Obesidad y la Nutricion, CIBERobn, Instituto de Salud Carlos III,
   Spain). We also thank the IDI-20150608 AVANZAS project from the Spanish
   Centre for the Development of Industrial Technology (CDTI, MINECO). This
   article has been partially funded by a H2020 SME Phase II project, grant
   number 783838.
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NR 47
TC 60
Z9 60
U1 1
U2 13
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PD JUN 1
PY 2018
VL 9
IS 6
BP 3173
EP 3184
DI 10.1039/c8fo00367j
PG 12
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA GK3GD
UT WOS:000436029300012
PM 29862395
OA hybrid, Green Submitted
DA 2025-06-11
ER

PT J
AU Llauradó, G
   Cano, A
   Hernández, C
   González-Sastre, M
   Rodríguez, AA
   Puntí, J
   Berianga, E
   Albert, L
   Simó, R
   Vendrell, J
   Clemente, JMG
AF Llaurado, Gemma
   Cano, Albert
   Hernandez, Cristina
   Gonzalez-Sastre, Montserrat
   Rodriguez, Ato-Antonio
   Punti, Jordi
   Berianga, Eugenio
   Albert, Lara
   Simo, Rafael
   Vendrell, Joan
   Gonzalez Clemente, Jose-Miguel
TI Type 1 diabetes: Developing the first riskestimation model for
   predicting silent myocardial ischemia. The potential role of insulin
   resistance
SO PLOS ONE
LA English
DT Article
ID CORONARY-ARTERY-DISEASE; METABOLIC SYNDROME; CARDIOVASCULAR-DISEASE;
   PITTSBURGH EPIDEMIOLOGY; HEART-ASSOCIATION; RISK; STIFFNESS;
   COMPLICATIONS; MORTALITY; MELLITUS
AB Objectives
   The aim of the study was to develop a novel risk estimation model for predicting silent myocardial ischemia (SMI) in patients with type 1 diabetes (T1DM) and no clinical cardiovascular disease, evaluating the potential role of insulin resistance in such a model. Additionally, the accuracy of this model was compared with currently available models for predicting clinical coronary artery disease (CAD) in general and diabetic populations.
   Research, design and methods
   Patients with T1DM (35-65years, >10-year duration) and no clinical cardiovascular disease were consecutively evaluated for: 1) clinical and anthropometric data (including classical cardiovascular risk factors), 2) insulin sensitivity (estimate of glucose disposal rate (eGDR)), and 3) SMI diagnosed by stress myocardial perfusion gated SPECTs.
   Results
   Eighty-four T1DM patients were evaluated [50.1 +/- 9.3 years, 50% men, 36.9% active smokers, T1DM duration: 19.0(15.9-27.5) years and eGDR 7.8(5.5-9.4) mg.kg(-1).min(-1)]. Of these, ten were diagnosed with SMI (11.9%). Multivariate logistic regression models showed that only eGDR (OR = -0.593, p = 0.005) and active smoking (OR = 7.964, p = 0.018) were independently associated with SMI. The AUC of the ROC curve of this risk estimation model for predicting SMI was 0.833 (95% CI:0.692-0.974), higher than those obtained with the use of currently available models for predicting clinical CAD (Framingham Risk Equation: 0.833 vs. 0.688, p = 0.122; UKPDS Risk Engine (0.833 vs. 0.559; p = 0.001) and EDC equation: 0.833 vs. 0.558, p = 0.027).
   Conclusion
   This study provides the first ever reported risk-estimation model for predicting SMI in T1DM. The model only includes insulin resistance and active smoking as main predictors of SMI.
C1 [Llaurado, Gemma] Hosp del Mar, Dept Endocrinol & Nutr, Barcelona, Spain.
   [Llaurado, Gemma; Hernandez, Cristina; Simo, Rafael; Vendrell, Joan; Gonzalez Clemente, Jose-Miguel] Inst Salud Carlos III, Ctr Invest Biomed Red Diabet & Enfermedades Metab, Madrid, Spain.
   [Cano, Albert; Albert, Lara; Gonzalez Clemente, Jose-Miguel] Univ Autonoma Barcelona, Inst Invest & Innovacio Parc Tauli I3PT, Parc Tauli Hosp Univ, Dept Endocrinol & Nutr, Sabadell, Spain.
   [Hernandez, Cristina; Simo, Rafael] Univ Autonoma Barcelona, Inst Recerca, Hosp Univ Vail dHebron, Diabet & Metab Res Unit, Barcelona, Spain.
   [Gonzalez-Sastre, Montserrat] Univ Autonoma Barcelona, Inst Invest & Innovacio Parc Tauli I3PT, Parc Tauli Hosp Univ, Ophthalmol Dept, Sabadell, Spain.
   [Rodriguez, Ato-Antonio] Univ Autonoma Barcelona, Inst Invest & Innovacio Parc Tauli I3PT, UDIAT Ctr Diagnost, Nucl Med Dept, Sabadell, Spain.
   [Punti, Jordi] Univ Autonoma Barcelona, Inst Invest & Innovacio Parc Tauli I3PT, Parc Tauli Hosp Univ, Cardiol Dept, Sabadell, Spain.
   [Berianga, Eugenio] Univ Autonoma Barcelona, Inst Invest & Innovacio Parc Tauli I3PT, UDIAT Ctr Diagnost, Biochem Dept, Sabadell, Spain.
   [Vendrell, Joan] Univ Rovira & Virgili, IISPV, Hosp Univ Joan 23 Tarragona, Tarragona, Spain.
C3 Hospital del Mar Research Institute; Hospital del Mar; Instituto de
   Salud Carlos III; CIBER - Centro de Investigacion Biomedica en Red;
   CIBERDEM; Autonomous University of Barcelona; Parc Tauli Hospital
   Universitari; Autonomous University of Barcelona; Hospital Universitari
   Vall d'Hebron; Vall d'Hebron Institut de Recerca (VHIR); Autonomous
   University of Barcelona; Parc Tauli Hospital Universitari; Autonomous
   University of Barcelona; Parc Tauli Hospital Universitari; Autonomous
   University of Barcelona; Parc Tauli Hospital Universitari; Autonomous
   University of Barcelona; Parc Tauli Hospital Universitari; Universitat
   Rovira i Virgili; Institut d'Investigacio Sanitaria Pere Virgili (IISPV)
RP Clemente, JMG (corresponding author), Inst Salud Carlos III, Ctr Invest Biomed Red Diabet & Enfermedades Metab, Madrid, Spain.; Clemente, JMG (corresponding author), Univ Autonoma Barcelona, Inst Invest & Innovacio Parc Tauli I3PT, Parc Tauli Hosp Univ, Dept Endocrinol & Nutr, Sabadell, Spain.
EM josmi.gonza@gmail.com
RI hernandez, cristina/KGL-9001-2024; Llauradó, Gemma/AAB-9839-2020;
   Stefanadis, Christodoulos/ABH-2232-2020; Vendrell Ortega, Joan
   Josep/V-4034-2018
OI Hernandez, Cristina/0000-0002-3109-1721; Stefanadis,
   Christodoulos/0000-0001-5974-6454; Vendrell Ortega, Joan
   Josep/0000-0002-6994-6115; Simo Canonge, Rafael/0000-0003-0475-3096;
   Albert Fabregas, Lara/0000-0003-3711-918X; Cano Palomares,
   Albert/0000-0002-2804-3745
FU Associacio Catalana de Diabetis (Beca Goncal Lloveras); Fondo de
   Investigacion Sanitaria (FIS) as part of the National R+D+I
   [PI12/00954]; Institute de Salud Carlos III - General Evaluation Branch
   (Spanish Ministry of Economy and Competitiveness); European Regional
   Development Fund (ERDF); "Rio Hortega" research fellowship from the
   Institute de Salud Carlos III (Spain) [CM12/00044]
FX Financial support was provided through a grant from the Associacio
   Catalana de Diabetis (Beca Goncal Lloveras 2012) and the Fondo de
   Investigacion Sanitaria (FIS) PI12/00954 as part of the National R+D+I
   (2008-2011) and was cofinanced by the Institute de Salud Carlos III -
   General Evaluation Branch (Spanish Ministry of Economy and
   Competitiveness) and the European Regional Development Fund (ERDF). G.
   Llaurado was supported by a "Rio Hortega" research fellowship
   (CM12/00044) from the Institute de Salud Carlos III (Spain).
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NR 45
TC 9
Z9 9
U1 0
U2 4
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD APR 3
PY 2017
VL 12
IS 4
AR e0174640
DI 10.1371/journal.pone.0174640
PG 14
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA ES2IH
UT WOS:000399351000028
PM 28369151
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Abdallah, E
   El-Shishtawy, S
   Sherif, N
   Ali, A
   El-Bendary, O
AF Abdallah, Emad
   El-Shishtawy, Samya
   Sherif, Nevine
   Ali, Ahmed
   El-Bendary, Omnia
TI Assessment of the relationship between serum paraoxonase activity and
   epicardial adipose tissue in hemodialysis patients
SO INTERNATIONAL UROLOGY AND NEPHROLOGY
LA English
DT Article
DE Epicardial adipose tissue; Hemodialysis; Paraoxonase-1 activity
ID STAGE RENAL-DISEASE; PON1 LACTONASE ACTIVITY; OXIDATIVE STRESS; FAT
   TISSUE; METABOLIC SYNDROME; THICKNESS; ATHEROSCLEROSIS; FAILURE;
   INFLAMMATION; CHOLESTEROL
AB Paraoxonase-1 (PON-1) is a high-density lipoprotein-associated (HDL) enzyme, which has been shown to reduce susceptibility to low-density lipoprotein (LDL) peroxidation. Epicardial adipose tissue (EAT) is a marker of atherosclerosis. The aim of this study was to determine the relationship between PON-1 activity and EAT in hemodialysis (HD) patients.
   This is a cross-sectional study conducted on 72 (43 males) HD patients with end-stage renal disease. Serum levels for lipid profiles, C-reactive protein, calcium, phosphate, and parathyroid hormone were measured. PON-1 activity was also measured and compared to the rate of enzymatic hydrolysis of paraoxon to p-nitrophenol. Echocardiography was used to measure EAT thickness (EATT). The correlation between PON-1 and EATT was assessed, while independent predictors of EATT in HD patients were similarly assessed using multivariate regression analysis.
   There was a significant low mean value of PON-1 activity in HD patients compared with the control group (82.1 +/- 31.6 vs. 164.3 +/- 61.5 U/l, p = 0.0001) and significant high mean value of EATT in HD patients, compared with controls (6.2 +/- 1.7 vs. 3.9 +/- 1.1 mm, p = 0.0001). In addition, there was a significant negative correlation between PON-1 activity and EATT (r = -0.484, p = 0.0001) and a significant positive correlation between PON-1 activity and HDL-C (r = 0.417, p = 0.0003). PON-1, total cholesterol, triglycerides, LDL, HDL, age, and body mass index were found to be independent predictors of EATT.
   Our study demonstrated that PON-1 activity was significantly lower in HD patients compared with healthy controls and that PON-1 activity was inversely correlated with EATT in this population.
C1 [Abdallah, Emad; El-Shishtawy, Samya; Sherif, Nevine] Theodor Bilharz Res Inst, Dept Nephrol, El Nile St Waraq El Hadar,POB 30, Giza 12411, Egypt.
   [Ali, Ahmed] Theodor Bilharz Res Inst, Dept Intens Care Unit, Cairo, Egypt.
   [El-Bendary, Omnia] Theodor Bilharz Res Inst, Dept Clin Chem, Cairo, Egypt.
C3 Egyptian Knowledge Bank (EKB); Theodor Bilharz Research Institute
   (TBRI); Egyptian Knowledge Bank (EKB); Theodor Bilharz Research
   Institute (TBRI); Egyptian Knowledge Bank (EKB); Theodor Bilharz
   Research Institute (TBRI)
RP Abdallah, E (corresponding author), Theodor Bilharz Res Inst, Dept Nephrol, El Nile St Waraq El Hadar,POB 30, Giza 12411, Egypt.
EM drabdallah96@gmail.com
RI Sherif, Nevine/AAG-6641-2021; Ali, Ahmed/ABI-1550-2020
OI Sherif, Nevine/0000-0002-7436-0303
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NR 34
TC 12
Z9 13
U1 0
U2 13
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0301-1623
EI 1573-2584
J9 INT UROL NEPHROL
JI Int. Urol. Nephrol.
PD FEB
PY 2017
VL 49
IS 2
BP 329
EP 335
DI 10.1007/s11255-016-1465-y
PG 7
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA EK8CJ
UT WOS:000394151200023
PM 27878751
DA 2025-06-11
ER

PT J
AU Jung, CH
   Lee, MJ
   Kang, YM
   Hwang, JY
   Jang, JE
   Leem, J
   Park, JY
   Kim, HK
   Lee, WJ
AF Jung, Chang Hee
   Lee, Min Jung
   Kang, Yu Mi
   Hwang, Jenie Yoonoo
   Jang, Jung Eun
   Leem, Jaechan
   Park, Joong-Yeol
   Kim, Hong-Kyu
   Lee, Woo Je
TI Higher serum bilirubin level as a protective factor for the development
   of diabetes in healthy Korean men: A 4 year retrospective longitudinal
   study
SO METABOLISM-CLINICAL AND EXPERIMENTAL
LA English
DT Article
DE Bilirubin; Type 2 diabetes; Antioxidant
ID METABOLIC SYNDROME; INSULIN-RESISTANCE; CARDIOVASCULAR-DISEASE;
   OXIDATIVE STRESS; ASSOCIATION; ANTIOXIDANT; GLUCOSE; PREVALENCE;
   EXPRESSION; ADULTS
AB Objective. Bilirubin, a natural product of heme catabolism by heme oxygenase, one of key antioxidant enzymes, has been recognized as a substance with potent antioxidant and cytoprotective properties. Several studies have shown a significant negative relationship between serum bilirubin levels and the risk of metabolic disorders, including type 2 diabetes. However, longitudinal studies investigating the association of elevated serum bilirubin levels and type 2 diabetes are lacking. In the present study, we aimed to investigate the longitudinal effects of baseline serum bilirubin concentrations on the development of type 2 diabetes in healthy Korean men.
   Materials and Methods. This 4 year retrospective longitudinal observational study was conducted at the Asan Medical Center, Seoul, Republic of Korea. The study population consisted of 5960 men without type 2 diabetes who underwent routine health examinations in 2007 (baseline) and 2011 (follow-up). Baseline serum bilirubin concentrations were determined by the vanadate oxidation method.
   Results. During a 4 year period, 409 incident cases of diabetes (6.9 %) were identified. Incident type 2 diabetes decreased across the baseline bilirubin quartile categories (P for trend <0.001). In multivariable-adjusted model, the relative risk (RR) for the development of type 2 diabetes was significantly lower in the highest (i.e., 1.30-2.00 mg/dl) than in the lowest bilirubin quartile category (i.e., <= 0.90 mg/dl), even after adjustment for confounding variables (RR = 0.69, 95% confidence interval 0.48-0.99, P for trend = 0.041).
   Conclusions. The results indicate that serum total bilirubin level may provide additional information for predicting future development of type 2 diabetes in healthy subjects. (C) 2014 Elsevier Inc. All rights reserved.
C1 [Jung, Chang Hee; Lee, Min Jung; Kang, Yu Mi; Jang, Jung Eun; Leem, Jaechan; Park, Joong-Yeol; Lee, Woo Je] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Internal Med, Seoul 138736, South Korea.
   [Hwang, Jenie Yoonoo; Kim, Hong-Kyu] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Hlth Screening, Seoul 138736, South Korea.
   [Hwang, Jenie Yoonoo; Kim, Hong-Kyu] Univ Ulsan, Coll Med, Asan Med Ctr, Promot Ctr, Seoul 138736, South Korea.
C3 University of Ulsan; Asan Medical Center; University of Ulsan; Asan
   Medical Center; University of Ulsan; Asan Medical Center
RP Lee, WJ (corresponding author), Univ Ulsan, Coll Med, Asan Med Ctr, Dept Internal Med, 388-1 Poongnap Dong, Seoul 138736, South Korea.
EM hkkim0801@amc.seoul.kr; lwjatlas@naver.com
RI Leem, Jaechan/AAQ-6648-2020; Kim, Seunghyun/AAA-3402-2022; Jung,
   Chang/AAU-7897-2020; Kim, Tae-Hee/AAN-9079-2021; Kang, Yu/AAW-2935-2020
OI Jung, Chang Hee/0000-0003-4043-2396; Leem, Jaechan/0000-0003-2329-4374
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TC 56
Z9 60
U1 0
U2 17
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0026-0495
EI 1532-8600
J9 METABOLISM
JI Metab.-Clin. Exp.
PD JAN
PY 2014
VL 63
IS 1
BP 87
EP 93
DI 10.1016/j.metabol.2013.09.011
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 277DP
UT WOS:000328799400011
PM 24140099
DA 2025-06-11
ER

PT J
AU Mietus-Snyder, ML
   Shigenaga, MK
   Suh, JH
   Shenvi, SV
   Lal, A
   McHugh, T
   Olson, D
   Lilienstein, J
   Krauss, RM
   Gildengoren, G
   McCann, JC
   Ames, BN
AF Mietus-Snyder, Michele L.
   Shigenaga, Mark K.
   Suh, Jung H.
   Shenvi, Swapna V.
   Lal, Ashutosh
   McHugh, Tara
   Olson, Don
   Lilienstein, Joshua
   Krauss, Ronald M.
   Gildengoren, Ginny
   McCann, Joyce C.
   Ames, Bruce N.
TI A nutrient-dense, high-fiber, fruit-based supplement bar increases HDL
   cholesterol, particularly large HDL, lowers homocysteine, and raises
   glutathione in a 2-wk trial
SO FASEB JOURNAL
LA English
DT Article
DE antioxidant status; cardiovascular disease risk; dyslipidemia; lipid
   particles; obesity
ID CARDIOVASCULAR RISK-FACTORS; POLYUNSATURATED FATTY-ACIDS;
   CORONARY-HEART-DISEASE; RANDOMIZED CONTROLLED-TRIALS; METABOLIC
   SYNDROME; LIPOPROTEIN CHOLESTEROL; INSULIN-RESISTANCE; FOLIC-ACID;
   OXIDATIVE STRESS; GLYCEMIC INDEX
AB Dietary intake modulates disease risk, but little is known how components within food mixtures affect pathophysiology. A low-calorie, high-fiber, fruit-based nutrient-dense bar of defined composition (e. g., vitamins and minerals, fruit polyphenolics, beta-glucan, docosahexaenoic acid) appropriate for deconstruction and mechanistic studies is described and evaluated in a pilot trial. The bar was developed in collaboration with the U. S. Department of Agriculture. Changes in cardiovascular disease and diabetes risk biomarkers were measured after 2 wk twice-daily consumption of the bar, and compared against baseline controls in 25 healthy adults. Plasma HDL-cholesterol (HDL-c) increased 6.2% (P = 0.001), due primarily to a 28% increase in large HDL (HDL-L; P<0.0001). Total plasma homocysteine (Hcy) decreased 19% (P = 0.017), and glutathione (GSH) increased 20% (P = 0.011). The changes in HDL and Hcy are in the direction associated with decreased risk of cardiovascular disease and cognitive decline; increased GSH reflects improved antioxidant defense. Changes in biomarkers linked to insulin resistance and inflammation were not observed. A defined food-based supplement can, within 2 wk, positively impact metabolic biomarkers linked to disease risk. These results lay the groundwork for mechanistic/deconstruction experiments to identify critical bar components and putative synergistic combinations responsible for observed effects.-Mietus-Snyder, M. L., Shigenaga, M. K., Suh, J. H., Shenvi, S. V., Lal, A., McHugh, T., Olson, D., Lilienstein, J., Krauss, R. M., Gildengoren, G., McCann, J. C., Ames, B. N. A nutrient-dense, high-fiber, fruit-based supplement bar increases HDL cholesterol, particularly large HDL, lowers homo-cysteine, and raises glutathione in a 2-wk trial. FASEB J. 26, 3515-3527 (2012). www.fasebj.org
C1 [Mietus-Snyder, Michele L.; Shigenaga, Mark K.; Suh, Jung H.; Shenvi, Swapna V.; Lal, Ashutosh; Krauss, Ronald M.; Gildengoren, Ginny; McCann, Joyce C.; Ames, Bruce N.] Childrens Hosp Oakland Res Inst, Nutr & Metab Ctr, Oakland, CA 94609 USA.
   [McHugh, Tara; Olson, Don] ARS, Proc Foods Res Unit, USDA, Western Reg Res Ctr, Albany, CA USA.
C3 Children's Hospital Oakland Research Institute; University of California
   System; University of California San Francisco; UCSF Medical Center;
   UCSF Benioff Children's Hospital Oakland; United States Department of
   Agriculture (USDA)
RP Shigenaga, MK (corresponding author), Childrens Hosp Oakland Res Inst, Nutr & Metab Ctr, 5700 Martin Luther King Jr Way, Oakland, CA 94609 USA.
EM mshigenaga@chori.org; bames@chori.org
RI Krauss, Ronald M./LTD-4078-2024
OI Lilienstein, Joshua/0000-0003-3189-9170; Mietus-Snyder,
   Michele/0000-0003-2791-9896
FU U.S. National Institutes of Health [UL1RR024131]; Bruce and Giovanna
   Ames Foundation; Department of Atherosclerosis Research at Children's
   Hospital Oakland Research Institute; S. D. Bechtel, Jr. Foundation
FX Many thanks to Alicia Zhou, Casey Geaney, Katie Woojinski, and Devan
   Block for technical assistance, the extraordinary staff at the Pediatric
   Clinical Research Center (PCRC) at Children's Hospital Oakland,
   especially Annie Higa and Vivian Ng. M. K. S. thanks Wally Yokoyama for
   helpful discussions on soluble fibers. The authors also thank Pharmachem
   Laboratories (Kearny, NJ, USA) for donating a nutrient blend for the
   study and Teresa Klask for invaluable administrative assistance. This
   publication was made possible by U.S. National Institutes of Health
   Clinical and Translational Science Award grant UL1RR024131. Additional
   support was from the Bruce and Giovanna Ames Foundation (J.C.M., M. M.
   S., M. K. S., J.H.S., S. V. S., A. L.), the Department of
   Atherosclerosis Research at Children's Hospital Oakland Research
   Institute (R. M. K.), and the S. D. Bechtel, Jr. Foundation (J.H.S.).
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NR 175
TC 25
Z9 28
U1 0
U2 34
PU FEDERATION AMER SOC EXP BIOL
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3998 USA
SN 0892-6638
EI 1530-6860
J9 FASEB J
JI Faseb J.
PD AUG
PY 2012
VL 26
IS 8
BP 3515
EP 3527
DI 10.1096/fj.11-201558
PG 13
WC Biochemistry & Molecular Biology; Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 984BI
UT WOS:000307162800038
PM 22549511
OA Green Published
DA 2025-06-11
ER

PT J
AU Alexandraki, KI
   Grossman, AB
AF Alexandraki, Krystallenia I.
   Grossman, Ashley B.
TI Novel Insights in the Diagnosis of Cushing's Syndrome
SO NEUROENDOCRINOLOGY
LA English
DT Article; Proceedings Paper
CT 1st ENEA Workshop on Novel Insight in the Management of Cushing's
   Syndrome
CY DEC 04-06, 2009
CL Naples, ITALY
DE Salivary cortisol; Late-night salivary cortisol; Bed-time salivary
   cortisol; Midnight serum cortisol; Dexamethasone suppression test;
   Cushing's syndrome
ID DEXAMETHASONE-SUPPRESSION TEST; NIGHT SALIVARY CORTISOL;
   CORTICOTROPIN-RELEASING-HORMONE; CORTICOSTEROID-BINDING GLOBULIN;
   PITUITARY-ADRENAL-FUNCTION; MIDNIGHT SERUM CORTISOL; URINARY FREE
   CORTISOL; DIFFERENTIAL-DIAGNOSIS; SCREENING-TEST; PLASMA-FREE
AB Cushing's syndrome (CS) results from sustained pathologic hypercortisolism. Increased identification of cyclical CS and the similarities between the metabolic syndrome and mild CS has resulted in an increased prevalence of CS, necessitating more accurate diagnostic tests to screen and diagnose CS in its earliest stages. Many studies have examined the utility of resistance to steroid feedback by the dexamethasone suppression tests and increases in secretion assessing 24-hour urinary free cortisol; however, the most sensitive indicator is the loss of circadian rhythmicity. Therefore, midnight sleeping cortisol is undoubtedly an extremely sensitive indicator of CS but impractical for screening purposes. In this situation assessment late-night salivary cortisol (NSC) is being increasingly investigated as a simple and convenient outpatient procedure. Salivary cortisol has also been used in stimulation or suppression tests because of the detection of rapid changes in cortisol concentration. This paper discusses the effectiveness of SC as a putative accurate, stress-free, and non-invasive sampling procedure. Some studies have shown no difference between tests while others demonstrated a higher sensitivity of SC, while the combination of tests seems to increase their diagnostic value. However, the different assays used for SC estimation and the variable types of control groups in the published studies render a comparison of studies difficult. In conclusion, NSC measurement is increasingly being used as a first-line test for CS, but we recommend that local centres establish their own normative ranges, and there is still a place for the more traditional tests to confirm the diagnosis. Copyright (C) 2010 S. Karger AG, Basel
C1 [Alexandraki, Krystallenia I.; Grossman, Ashley B.] St Bartholomews Hosp, Dept Endocrinol, London EC1A 7BE, England.
C3 University of London; Queen Mary University London
RP Grossman, AB (corresponding author), St Bartholomews Hosp, Dept Endocrinol, London EC1A 7BE, England.
EM a.b.grossman@qmul.ac.uk
RI Alexandraki, Krystallenia/S-4058-2019
OI Alexandraki, Krystallenia/0000-0003-2398-6768
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NR 77
TC 21
Z9 25
U1 0
U2 4
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0028-3835
EI 1423-0194
J9 NEUROENDOCRINOLOGY
JI Neuroendocrinology
PY 2010
VL 92
SU 1
BP 35
EP 43
DI 10.1159/000314295
PG 9
WC Endocrinology & Metabolism; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Endocrinology & Metabolism; Neurosciences & Neurology
GA 648BN
UT WOS:000281665500008
PM 20829616
DA 2025-06-11
ER

PT J
AU Figarola, JL
   Loera, S
   Weng, Y
   Shanmugam, N
   Natarajan, R
   Rahbar, S
AF Figarola, J. L.
   Loera, S.
   Weng, Y.
   Shanmugam, N.
   Natarajan, R.
   Rahbar, S.
TI LR-90 prevents dyslipidaemia and diabetic nephropathy in the Zucker
   diabetic fatty rat
SO DIABETOLOGIA
LA English
DT Article
DE AGE inhibition; diabetic nephropathy; dyslipidaemia; extracellular
   matrix; glomerulosclerosis; glycation; oxidative stress; renal fibrosis;
   renal protection; type 2 diabetes
ID GLYCATION END-PRODUCTS; ANGIOTENSIN-CONVERTING ENZYME; TISSUE
   GROWTH-FACTOR; LIPID-PEROXIDATION; INHIBITORS; MODEL; AGE; PATHOGENESIS;
   BLOCKADE; RAGE
AB Aims/hypothesis Previous studies have shown that LR-90, a new inhibitor of AGE formation, prevented the development of experimental type 1 diabetic nephropathy. In this study, we examined the effects of LR-90 in the Zucker diabetic fatty (ZDF) rat, a model of type 2 diabetes and metabolic syndrome, and investigated the mechanisms by which it may protect against renal injury.
   Methods Male ZDF rats were treated without or with LR-90 from age 13 to 40 weeks. Metabolic and kidney functions and renal histology were evaluated. AGE accumulation and the production of the receptor for AGE (AGER) were measured. Profibrotic growth factors, extracellular matrix proteins and intracellular signalling pathways associated with glomerular and tubular damage were also analysed.
   Results LR-90 dramatically reduced plasma lipids in ZDF rats, with only modest effects on hyperglycaemia. Renal AGE, AGER and lipid peroxidation were all attenuated by LR-90. LR-90 significantly retarded the increase in albuminuria and proteinuria. This was associated with reduction in glomerulosclerosis and tubulointerstitial fibrosis, concomitant with marked inhibition of renal overproduction of TGF-beta 1, connective tissue growth factor, fibronectin and collagen IV. Additionally, LR-90 downregulated the activation of key mitogen-activated protein kinases (MAPKs) and nuclear factor kappa B (NF-kappa B) in the renal cortex.
   Conclusions/Interpretation These results support our earlier studies on the renoprotective effects of LR-90 on type 1 diabetic nephropathy and provide further evidence that LR-90, an AGE inhibitor with pleiotrophic effects, may also be beneficial for the prevention of type 2 diabetic nephropathy, where multiple risk factors, such as hyperglycaemia, dyslipidaemia, obesity, insulin resistance and hypertension, contribute to renal injury.
C1 [Figarola, J. L.; Weng, Y.; Shanmugam, N.; Natarajan, R.; Rahbar, S.] City Hope Natl Med Ctr, Dept Diabet Endocrinol & Metab, Duarte, CA 91010 USA.
   [Loera, S.] City Hope Natl Med Ctr, Dept Anat Pathol, Duarte, CA 91010 USA.
C3 City of Hope; City of Hope
RP Rahbar, S (corresponding author), City Hope Natl Med Ctr, Dept Diabet Endocrinol & Metab, Gonda Bldg,1500 E Duarte Rd, Duarte, CA 91010 USA.
EM srahbar@coh.org
OI shanmugam, narkunaraja/0000-0002-5981-8048
FU NCI NIH HHS [P30 CA033572] Funding Source: Medline
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NR 51
TC 49
Z9 54
U1 0
U2 4
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0012-186X
EI 1432-0428
J9 DIABETOLOGIA
JI Diabetologia
PD MAY
PY 2008
VL 51
IS 5
BP 882
EP 891
DI 10.1007/s00125-008-0935-x
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 285AT
UT WOS:000254750400025
PM 18317729
OA Bronze
DA 2025-06-11
ER

PT J
AU Gao, YJ
   Takemori, K
   Su, LY
   An, WS
   Lu, C
   Sharma, AM
   Lee, RMKW
AF Gao, Yu-Jing
   Takemori, Kumiko
   Su, Li-Ying
   An, Wen-Sheng
   Lu, Chao
   Sharma, Arya M.
   Lee, Robert M. K. W.
TI Perivascular adipose tissue promotes vasoconstriction: The role of
   superoxide anion
SO CARDIOVASCULAR RESEARCH
LA English
DT Article
DE adipose tissue; contraction; MAPK; mesenteric artery; perivascular nerve
   stimulation; superoxide anion
ID SPONTANEOUSLY HYPERTENSIVE-RATS; NITRIC-OXIDE RELEASE; PROTEIN-KINASE-C;
   SIGNAL-REGULATED KINASE; MESENTERIC-ARTERIES; OXIDATIVE STRESS;
   CARDIOVASCULAR-DISEASE; CORONARY-ARTERIES; ENDOTHELIAL-CELLS; METABOLIC
   SYNDROME
AB Objectives: Recent studies have demonstrated that perivascular adipose tissue (PVAT) releases vascular relaxation factor(s). In this study, we examined if PVAT releases other vasoactive factors in response to perivascular nerve activation by electrical field stimulation (EFS).
   Methods and results: In Wistar-Kyoto rats, rings of superior mesenteric artery (MA) with intact PVAT (PVAT (+)) showed a greater contractile response to EFS than rings with PVAT removed (PVAT (-)). Superoxide dismutase (SOD) reduced the contractile response to EFS more in PVAT (+) MA than in PVAT (-) MA. Inhibitors of NAD(P)H oxidase and cyclooxygenase exerted a greater inhibition on EFS-induced contraction in PVAT (+) MA than in PVAT (-) MA. Inhibitors of tyrosine kinase (tyrphostin A25) and MAPK/ERK (U 0126) attenuated EFS-induced contraction in PVAT (+) MA in a concentration-related manner, while inactive forms of these inhibitors (tyrphostin A1 and U 0124) did not inhibit the response. Exogenous superoxide augmented the contractile response to EFS and to phenylephrine in PVAT (-) MA, and this augmentation was blunted by inhibition of tyrosine kinase and MAPK/ERK. EFS increased superoxide generation in isolated PVAT and PVAT (+)/(-) MA, which was attenuated by NAD(P)H oxidase inhibition. RTPCR showed the mRNA expression of p67(phox) subunit of NAD(P)H oxidase and immunohistochemical staining confirmed its localization in the adipocytes of PVAT.
   Conclusion: These results show that PVAT enhances the arterial contractile response to perivascular nerve stimulation through the production of superoxide mediated by NAD(P)H oxidase, and that this enhancement involves activation of tyrosine kinase and MAPK/ERK pathway. (c) 2006 European Society of Cardiology. Published by Elsevier B.V All rights reserved.
C1 McMaster Univ, Smooth Muscle Res Program, Hamilton, ON L8N 3Z5, Canada.
   McMaster Univ, Dept Anaesthesia, Hamilton, ON L8N 3Z5, Canada.
   McMaster Univ, Dept Med, Hamilton, ON L8N 3Z5, Canada.
C3 McMaster University; McMaster University; McMaster University
RP Gao, YJ (corresponding author), McMaster Univ, Smooth Muscle Res Program, 12, Hamilton, ON L8N 3Z5, Canada.
EM gaoyu@mcmaster.ca
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NR 48
TC 191
Z9 209
U1 0
U2 21
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0008-6363
EI 1755-3245
J9 CARDIOVASC RES
JI Cardiovasc. Res.
PD JUL 15
PY 2006
VL 71
IS 2
BP 363
EP 373
DI 10.1016/j.cardiores.2006.03.013
PG 11
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 065MP
UT WOS:000239164300018
PM 16756966
OA Bronze
DA 2025-06-11
ER

PT J
AU Sumedha
   Chatterjee, S
AF Sumedha
   Chatterjee, Subhasish
TI The Influence of Yoga on HbA1c Levels in Patients with Type 2 Diabetes
   Mellitus: A Systematic Review
SO JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH
LA English
DT Article
DE Glycaemic control; Insulin; Metabolic diseases
ID METABOLIC SYNDROME; OXIDATIVE STRESS; GLYCEMIC CONTROL; PARAMETERS
AB Introduction: Type 2 Diabetes Mellitus (T2DM) is a chronic metabolic disease characterised by insulin resistance and hyperglycaemia due to insulin deficiency. Despite advances in traditional treatment approaches, achieving and maintaining optimal glycaemic control remains a clinical challenge. Aim: To thoroughly evaluate and summarise the available evidence on the effects of yoga on HbA1c levels in patients with T2DM. Materials and Methods: The present review was a systematic review in which five electronic databases were searched: PubMed/MedLine, SCOPUS, the Cochrane Library (including ICTRP and EMBASE), and the Physiotherapy Evidence Database (PEDro). The keywords used were "yoga", "HbA1c", "diabetes" and "T2DM". Google Scholar was also searched for supplementary information and manually reviewed references from identified publications. After removing duplicates and making the full text available, 24 articles were included in the systematic review. Results: This systematic review demonstrates the benefits of various yoga techniques for patients with T2DM. The review primarily focused on fasting blood glucose, postprandial blood glucose, hormone levels, lipid profiles, blood pressure, cardiac function, vitamin C and E levels, anthropometric measurements, quality of life and psychological factors. This review aids in predicting the benefits of various yoga techniques as an integrated approach and assesses the cumulative benefits of medication among patients with diabetes. Out of the 24 included studies, numerous yogic practices were employed; seven studies used Suryanamaskar, eight studies used Trikonasana and the remainder utilised Padmasana, Paschimottasana, Tadasana, Mandukasana, Ardh Matsyendrasana, Sukhasana and others. The studies also incorporated various Pranayamas, including Sudarshan Kriya, Bhastrika, Bhramari, Kapalbhati, Nadi Shuddhi, Viparitakarani, Sitkari, Anuloma-Viloma, and Om chanting. Conclusion: This review highlights the benefits of various yoga techniques as an integrated approach and underlines the cumulative benefits of pharmacological treatment in patients with diabetes.
C1 [Sumedha; Chatterjee, Subhasish] Maharishi Markandeshwar Deemed Univ, Maharishi Markandeshwar Inst Physiotherapy & Rehab, Dept Physiotherapy, Ambala 133207, Haryana, India.
RP Chatterjee, S (corresponding author), Maharishi Markandeshwar Deemed Univ, Maharishi Markandeshwar Inst Physiotherapy & Rehab, Dept Physiotherapy, Ambala 133207, Haryana, India.
EM subhasishphysio@mmumullana.org
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NR 48
TC 0
Z9 0
U1 0
U2 0
PU PREMCHAND SHANTIDEVI RESEARCH FOUNDATION
PI DELHI
PA 71 JAIN COLONY, VEER NAGAR, DELHI, 110 007, INDIA
SN 2249-782X
EI 0973-709X
J9 J CLIN DIAGN RES
JI J. Clin. Diagn. Res.
PD MAY
PY 2025
VL 19
IS 5
BP YC25
EP YC33
DI 10.7860/JCDR/2025/74551.21025
PG 9
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA 2ZH9F
UT WOS:001494896900011
DA 2025-06-11
ER

PT J
AU Van de Casteele, F
   Van Thienen, R
   Horwath, O
   Apró, W
   Van der Stede, T
   Moberg, M
   Lievens, E
   Derave, W
AF Van de Casteele, Freek
   Van Thienen, Ruud
   Horwath, Oscar
   Apro, William
   Van der Stede, Thibaux
   Moberg, Marcus
   Lievens, Eline
   Derave, Wim
TI Does one biopsy cut it? Revisiting human muscle fiber type composition
   variability using repeated biopsies in the vastus lateralis and
   gastrocnemius medialis
SO JOURNAL OF APPLIED PHYSIOLOGY
LA English
DT Article
DE across-muscle phenotype; cross-sectional area; fiber type composition;
   immunohistochemistry; myosin heavy chain
ID SKELETAL-MUSCLE; RESISTANCE ARTERIES; MICROVASCULAR RAREFACTION;
   METABOLIC SYNDROME; VASCULAR FUNCTION; BASIC MECHANISMS;
   SEX-DIFFERENCES; CHRONIC STRESS; K+ CHANNELS; FEMALE RATS
AB Human skeletal muscle fiber type composition varies greatly along the muscle, so one biopsy may not accurately represent the whole muscle. Recommendations on the number of biopsies and fiber counts using immunohistochemistry and whether these findings can be extrapolated to other muscles are lacking. We assessed fiber type composition in the vastus lateralis and gastrocnemius medialis muscles of 40 individuals. Per muscle, we took four biopsy samples from one incision, collecting two samples each from a proximally and distally directed needle. Based on another dataset involving 10 vastus lateralis biopsies per participant (n = 7), we calculated 95% limits of agreement for subsets of biopsies and fiber counts compared with the 10-biopsy average. Average absolute differences in type I fiber proportions between proximal and distal, and between within-needle samples were 6.9 and 4.5 percentage points in the vastus lateralis, and 5.5 and 4.4 percentage points in the gastrocnemius medialis, respectively. The 95% limits of agreement narrowed to +/- 10 percentage points when 200 fibers from at least three biopsies were analyzed, with minimal improvements with greater fiber counts. Type I fiber proportions in the vastus lateralis and gastrocnemius medialis showed a moderate positive association (r(2) = 0.22; P = 0.006; at least 200 fibers in each of three to four samples per muscle). In conclusion, three biopsies with a minimum of 200 counted fibers are required to estimate the vastus lateralis fiber type composition within +/- 10 percentage points. Even when using these standards, researchers should be cautious when extrapolating muscle fiber type proportions from one muscle to another.
C1 [Van de Casteele, Freek; Van Thienen, Ruud; Van der Stede, Thibaux; Lievens, Eline; Derave, Wim] Univ Ghent, Dept Movement & Sports Sci, Ghent, Belgium.
   [Horwath, Oscar; Apro, William; Moberg, Marcus] Swedish Sch Sport & Hlth Sci, Dept Physiol Nutr & Biomech, Astrand Lab, Stockholm, Sweden.
   [Apro, William] Karolinska Inst, Dept Clin Sci Intervent & Technol, Stockholm, Sweden.
   [Van der Stede, Thibaux] Univ Copenhagen, Dept Nutr Exercise & Sports, Copenhagen, Denmark.
   [Moberg, Marcus] Karolinska Inst, Dept Physiol & Pharmacol, Stockholm, Sweden.
C3 Ghent University; Swedish School of Sport & Health Sciences; Karolinska
   Institutet; University of Copenhagen; Karolinska Institutet
RP Derave, W (corresponding author), Univ Ghent, Dept Movement & Sports Sci, Ghent, Belgium.
EM Wim.Derave@UGent.be
RI Lievens, Eline/MTB-9290-2025; Apro, William/AAZ-4717-2020; Moberg,
   Marcus/AAU-5487-2021; Derave, Wim/B-2554-2014
OI Horwath, Oscar/0000-0002-3500-2896; Van der Stede,
   Thibaux/0000-0003-2038-2504; Derave, Wim/0000-0002-2225-5587; Apro,
   William/0000-0003-1942-2919; Moberg, Marcus/0000-0003-3747-0148; Van de
   Casteele, Freek/0000-0002-2107-9446
FU Research Foundation-Flanders [FWO 1S66923N]
FX The current project was funded by the Research Foundation-Flanders (FWO
   1S66923N).
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NR 61
TC 1
Z9 1
U1 2
U2 2
PU AMER PHYSIOLOGICAL SOC
PI Rockville
PA 6120 Executive Blvd, Suite 600, Rockville, MD, UNITED STATES
SN 8750-7587
EI 1522-1601
J9 J APPL PHYSIOL
JI J. Appl. Physiol.
PD NOV 3
PY 2024
VL 137
IS 5
BP 1341
EP 1353
DI 10.1152/japplphysiol.00394.2024
PG 13
WC Physiology; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology; Sport Sciences
GA N0L2O
UT WOS:001361342000002
PM 39359186
DA 2025-06-11
ER

PT J
AU Tai, GJ
   Ma, YJ
   Feng, JL
   Li, JP
   Qiu, S
   Yu, QQ
   Liu, RH
   Wankumbu, SC
   Wang, X
   Li, XX
   Xu, M
AF Tai, Guang-Jie
   Ma, Yan-Jie
   Feng, Jun-Lin
   Li, Jia-Peng
   Qiu, Shu
   Yu, Qing-Qing
   Liu, Ren-Hua
   Wankumbu, Silumbwe Ceaser
   Wang, Xin
   Li, Xiao-Xue
   Xu, Ming
TI NLRP3 inflammasome-mediated premature immunosenescence drives diabetic
   vascular aging dependent on the induction of perivascular adipose tissue
   dysfunction
SO CARDIOVASCULAR RESEARCH
LA English
DT Article
DE Type 2 diabetes; NLRP3 inflammasome; Immunosenescence; Vascular aging;
   PVAT dysfunction
ID T-CELL ACCUMULATION; ENDOTHELIAL-CELLS; METABOLIC SYNDROME; OXIDATIVE
   STRESS; ACTIVATION; OBESITY; MOUSE; IMMUNOMETABOLISM; CONSEQUENCES;
   MECHANISMS
AB Aims The vascular aging process accelerated by type 2 diabetes mellitus (T2DM) is responsible for the elevated risk of associated cardiovascular diseases. Metabolic disorder-induced immune senescence has been implicated in multi-organ/tissue damage. Herein, we sought to determine the role of immunosenescence in diabetic vascular aging and to investigate the underlying mechanisms.Methods and results Aging hallmarks of the immune system appear prior to the vasculature in streptozotocin (STZ)/high-fat diet (HFD)-induced T2DM mice or db/db mice. Transplantation of aged splenocytes or diabetic splenocytes into young mice triggered vascular senescence and injury compared with normal control splenocyte transfer. RNA sequencing profile and validation in immune tissues revealed that the toll-like receptor 4-nuclear factor-kappa B-NLRP3 axis might be the mediator of diabetic premature immunosenescence. The absence of Nlrp3 attenuated immune senescence and vascular aging during T2DM. Importantly, senescent immune cells, particularly T cells, provoked perivascular adipose tissue (PVAT) dysfunction and alternations in its secretome, which in turn impair vascular biology. In addition, senescent immune cells may uniquely affect vasoconstriction via influencing PVAT. Lastly, rapamycin alleviated diabetic immune senescence and vascular aging, which may be partly due to NLRP3 signalling inhibition.Conclusion These results indicated that NLRP3 inflammasome-mediated immunosenescence precedes and drives diabetic vascular aging. The contribution of senescent immune cells to vascular aging is a combined effect of their direct effects and induction of PVAT dysfunction, the latter of which can uniquely affect vasoconstriction. We further demonstrated that infiltration of senescent T cells in PVAT was increased and associated with PVAT secretome alterations. Our findings suggest that blocking the NLRP3 pathway may prevent early immunosenescence and thus mitigate diabetic vascular aging and damage, and targeting senescent T cells or PVAT might also be the potential therapeutic approach.
   Graphical Abstract
C1 [Tai, Guang-Jie; Ma, Yan-Jie; Feng, Jun-Lin; Li, Jia-Peng; Qiu, Shu; Liu, Ren-Hua; Wankumbu, Silumbwe Ceaser; Xu, Ming] China Pharmaceut Univ, Sch Basic Med & Clin Pharm, Dept Clin Pharm, 24 Tong Jia Lane, Nanjing 210009, Peoples R China.
   [Yu, Qing-Qing] Nanjing Univ Chinese Med, Affiliated Hosp, Jiangsu Prov Hosp Chinese Med, Nanjing, Peoples R China.
   [Wang, Xin] Univ Manchester, Fac Biol Med & Hlth, Manchester, England.
   [Li, Xiao-Xue] Southeast Univ, Zhongda Hosp, Sch Med, Dept Cardiol, 87 Dingjiaqiao, Nanjing 210009, Peoples R China.
C3 China Pharmaceutical University; Nanjing University of Chinese Medicine;
   University of Manchester; Southeast University - China
RP Xu, M (corresponding author), China Pharmaceut Univ, Sch Basic Med & Clin Pharm, Dept Clin Pharm, 24 Tong Jia Lane, Nanjing 210009, Peoples R China.; Li, XX (corresponding author), Southeast Univ, Zhongda Hosp, Sch Med, Dept Cardiol, 87 Dingjiaqiao, Nanjing 210009, Peoples R China.
EM lxx84112@163.com; mingxu@cpu.edu.cn
OI Silumbwe, Ceaser Wankumbu/0000-0002-9071-4212; Xu,
   Ming/0000-0002-0655-2610; Tai, Guang-Jie/0000-0001-8228-8826
FU National Natural Science Foundation of China [82373870]; Joint
   Laboratory Project of Jiangsu University International and Cooperation,
   Postgraduate Research & Practice Innovation Program of Jiangsu Province
   [5024002205]
FX This work was supported by grant 82373870 from the National Natural
   Science Foundation of China, Joint Laboratory Project of Jiangsu
   University International and Cooperation, Postgraduate Research &
   Practice Innovation Program of Jiangsu Province (No. 5024002205).
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NR 100
TC 9
Z9 9
U1 9
U2 17
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0008-6363
EI 1755-3245
J9 CARDIOVASC RES
JI Cardiovasc. Res.
PD JAN
PY 2025
VL 121
IS 1
BP 77
EP 96
DI 10.1093/cvr/cvae079
EA MAY 2024
PG 20
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 1PX8Y
UT WOS:001214377400001
PM 38643484
DA 2025-06-11
ER

PT J
AU Park, TY
   Choi, MY
   Kim, DS
   Yeo, JK
   Rajasekaran, M
   Park, MG
AF Park, Tae Yong
   Choi, Moon Young
   Kim, Dong Soo
   Yeo, Jeong Kyun
   Rajasekaran, Mahadevan
   Park, Min Gu
TI Correlation Analysis between Hypogonadal Symptoms and Changes in Body
   Composition and Physical Fitness after Testosterone Treatment in Men
   with Testosterone Deficiency
SO WORLD JOURNAL OF MENS HEALTH
LA English
DT Article
DE Body composition; Hormone replacement therapy; Hypgonadism; Lower
   urinary tract symptoms; Physical fitness; Testosterone
ID QUALITY-OF-LIFE; OLDER MEN; MUSCLE STRENGTH; DOUBLE-BLIND; MOBILITY;
   THERAPY; STRESS
AB Purpose: This study analyzed changes in body composition and physical fitness in men with testosterone deficiency (TD) after testosterone treatment (TT) and examined the correlations of body composition and physical fitness with serum testosterone levels and hypogonadal symptoms. Materials and Methods: Seventy patients with TD were divided into control (group I, n=23) and experimental (group II, n=47) groups. Patients in the experimental group were administered intramuscular testosterone enanthate (250 mg) for six months. The aging males symptom scale (AMS) score, international prostate symptom score (IPSS), body mass index, waist circumference, and serum laboratory values were measured at baseline and at the end of the study. Bioelectrical impedance analysis was used to assess the patients' body composition. Seven types of basic exercise tests were used to evaluate the patients' physical fitness. Results: After six months, there were no significant differences in group I, while group II had significantly improved IPSS and AMS scores; increased hemoglobin, hematocrit, prostate-specific antigen, and testosterone levels and skeletal muscle mass; and waist circumference, and body fat mass. All elements of the physical fitness test were significantly improved in group II, with the exceptions of flexibility and endurance. Decreased waist circumference was correlated with changes in testosterone levels in group II, and the IPSS, cardiorespiratory fitness, and agility were correlated with improved hypogonadal symptoms. Conclusions: TT improved the hypogonadal and lower urinary tract symptoms in patients with TD and improved body com-position, physical fitness, and metabolic syndrome parameters. Increased testosterone and improved hypogonadal symptoms were correlated with a decrease in waist circumference and an improvement in cardiorespiratory fitness and agility. As such, when implementing TT, we should consider whether these areas may be improved, as this can help to predict the effect.
C1 [Park, Tae Yong] Korea Univ, Grad Sch, Dept Med, Seoul, South Korea.
   [Park, Tae Yong] Eulji Univ, Uijeongbu Eulji Med Ctr, Dept Urol, Sch Med, Uijongbu, South Korea.
   [Choi, Moon Young] Inje Univ, Sports Med Ctr, Seoul Paik Hosp, Seoul, South Korea.
   [Choi, Moon Young] Inje Univ, Sports Med Res Inst, Seoul Paik Hosp, Seoul, South Korea.
   [Kim, Dong Soo] Kyung Hee Univ, Med Ctr, Sch Med, Dept Urol, Seoul, South Korea.
   [Yeo, Jeong Kyun; Park, Min Gu] Inje Univ, Seoul Paik Hosp, Dept Urol, Coll Med, 9 Mareunnae Ro, Seoul 04551, South Korea.
   [Rajasekaran, Mahadevan] Univ Calif San Diego, Dept Med, VA San Diego Hlth Care Syst, San Diego, CA USA.
C3 Korea University; Korea University Medicine (KU Medicine); Eulji
   University; Inje University; Inje University; Kyung Hee University; Inje
   University; US Department of Veterans Affairs; Veterans Health
   Administration (VHA); VA San Diego Healthcare System; University of
   California System; University of California San Diego
RP Park, MG (corresponding author), Inje Univ, Seoul Paik Hosp, Dept Urol, Coll Med, 9 Mareunnae Ro, Seoul 04551, South Korea.
EM uromgpark@gmail.com
RI Kim, Dong Soo/HZL-1310-2023; Kim, Yong Sung/GMW-8652-2022; Park, Min
   Gu/E-4486-2015
OI Park, Taeyong/0000-0002-6692-6397; Yeo, Jeongkyun/0000-0001-5027-3451;
   Choi, Moonyoung/0000-0002-1381-1166; Kim, Dong Soo/0000-0002-5696-0671
FU Korean Society for Sexual Medicine and Andrology; Inje University
   [20190029]
FX This study was supported by the Korean Society for Sexual Medicine and
   Andrology research funding in 2018. This work was supported by a grant
   from research year of Inje University in 20190029.
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NR 30
TC 1
Z9 1
U1 1
U2 5
PU KOREAN SOC SEXUAL MEDICINE & ANDROLOGY
PI BUSAN
PA PUSAN NATL UNIV MEDICAL SCH, DEPT UROLOGY, 179 GUDEOK-RO, SEO-GU, BUSAN,
   SOUTH KOREA
SN 2287-4208
EI 2287-4690
J9 WORLD J MENS HEALTH
JI World J. Mens Health
PD JAN
PY 2024
VL 42
IS 1
BP 178
EP 187
DI 10.5534/wjmh.220274
EA APR 2023
PG 10
WC Andrology; Health Care Sciences & Services; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Health Care Sciences & Services; Urology &
   Nephrology
GA EJ8D1
UT WOS:000975767600001
PM 37118963
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Johnson, RJ
   Tolan, DR
   Bredesen, D
   Nagel, M
   Sánchez-Lozada, LG
   Fini, M
   Burtis, S
   Lanaspa, MA
   Perlmutter, D
AF Johnson, Richard J.
   Tolan, Dean R.
   Bredesen, Dale
   Nagel, Maria
   Sanchez-Lozada, Laura G.
   Fini, Mehdi
   Burtis, Scott
   Lanaspa, Miguel A.
   Perlmutter, David
TI Could Alzheimer's disease be a maladaptation of an evolutionary survival
   pathway mediated by intracerebral fructose and uric acid metabolism?
SO AMERICAN JOURNAL OF CLINICAL NUTRITION
LA English
DT Review
DE Alzheimer's disease; fructose; metabolic syndrome; insulin resistance;
   energy metabolism
ID INSULIN-RESISTANCE; BRAIN GLUCOSE; COGNITIVE FUNCTION;
   ENERGY-METABOLISM; OXIDATIVE STRESS; INCIDENT DEMENTIA; POTENTIAL-ROLE;
   MALONYL-COA; EARLY-ONSET; RISK
AB An important aspect of survival is to assure enough food, water, and oxygen. Here, we describe a recently discovered response that favors survival in times of scarcity, and it is initiated by either ingestion or production of fructose. Unlike glucose, which is a source for immediate energy needs, fructose metabolism results in an orchestrated response to encourage food and water intake, reduce resting metabolism, stimulate fat and glycogen accumulation, and induce insulin resistance as a means to reduce metabolism and preserve glucose supply for the brain. How this survival mechanism affects brain metabolism, which in a resting human amounts to 20% of the overall energy demand, is only beginning to be understood. Here, we review and extend a previous hypothesis that this survival mechanism has a major role in the development of Alzheimer's disease and may account for many of the early features, including cerebral glucose hypometabolism, mitochondrial dysfunction, and neuroinflammation. We propose that the pathway can be engaged in multiple ways, including diets high in sugar, high glycemic carbohydrates, and salt. In summary, we propose that Alzheimer's disease may be the consequence of a maladaptation to an evolutionary-based survival pathway and what had served to enhance survival acutely becomes injurious when engaged for extensive periods. Although more studies are needed on the role of fructose metabolism and its metabolite, uric acid, in Alzheimer's disease, we suggest that both dietary and pharmacologic trials to reduce fructose exposure or block fructose metabolism should be performed to determine whether there is potential benefit in the prevention, management, or treatment of this disease.
C1 [Johnson, Richard J.] Rocky Mt VA Med Ctr, Dept Med, Aurora, CO 80045 USA.
   [Johnson, Richard J.; Fini, Mehdi; Lanaspa, Miguel A.] Univ Colorado, Dept Med, Anschutz Med Ctr, Aurora, CO 80045 USA.
   [Tolan, Dean R.] Boston Univ, Biol Dept, Boston, MA USA.
   [Bredesen, Dale] Univ Calif Los Angeles, David Geffen Sch Med, Dept Mol & Med Pharmacol, Los Angeles, CA USA.
   [Nagel, Maria] Univ Colorado, Dept Neurol, Anschutz Med Ctr, Aurora, CO USA.
   [Sanchez-Lozada, Laura G.] Natl Inst Cardiol Ignacio Chavez, Dept Cardiorenal Physiopathol, Mexico City, Mexico.
   [Burtis, Scott] Burtis Chiropract Ctr, Fairmont, MN USA.
   [Perlmutter, David] Univ Miami, Miller Sch Med, Miami, FL USA.
C3 University of Colorado System; University of Colorado Anschutz Medical
   Campus; Boston University; University of California System; University
   of California Los Angeles; University of California Los Angeles Medical
   Center; David Geffen School of Medicine at UCLA; University of Colorado
   System; University of Colorado Anschutz Medical Campus; National
   Institute of Cardiology - Mexico; University of Miami
RP Johnson, RJ (corresponding author), Rocky Mt VA Med Ctr, Dept Med, Aurora, CO 80045 USA.; Johnson, RJ (corresponding author), Univ Colorado, Dept Med, Anschutz Med Ctr, Aurora, CO 80045 USA.
EM Richard.johnson@cuanschutz.edu
RI Lanaspa, Miguel/AAO-4971-2020; Sanchez-Lozada, Laura/AAS-2104-2021
OI Tolan, Dean/0000-0002-0598-7241; Johnson, Richard/0000-0003-3312-8193
FU VA Merit [BXI01BX004511]; Veterans Health Administration
FX Funding This work was supported by VA Merit BXI01BX004511 from the
   Veterans Health Administration
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NR 169
TC 20
Z9 20
U1 2
U2 33
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0002-9165
EI 1938-3207
J9 AM J CLIN NUTR
JI Am. J. Clin. Nutr.
PD MAR
PY 2023
VL 117
IS 3
BP 455
EP 466
DI 10.1016/j.ajcnut.2023.01.002
EA MAR 2023
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA I2QW6
UT WOS:001001291100001
PM 36774227
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Tune, JD
   Goodwill, AG
   Baker, HE
   Dick, GM
   Warne, CM
   Tucker, SM
   Essajee, SI
   Bailey, CA
   Klasing, JA
   Russell, JJ
   McCallinhart, PE
   Trask, AJ
   Bender, SB
AF Tune, Johnathan D.
   Goodwill, Adam G.
   Baker, Hana E.
   Dick, Gregory M.
   Warne, Cooper M.
   Tucker, Selina M.
   Essajee, Salman, I
   Bailey, Chastidy A.
   Klasing, Jessica A.
   Russell, Jacob J.
   McCallinhart, Patricia E.
   Trask, Aaron J.
   Bender, Shawn B.
TI Chronic high-rate pacing induces heart failure with preserved ejection
   fraction-like phenotype in Ossabaw swine
SO BASIC RESEARCH IN CARDIOLOGY
LA English
DT Article
DE Coronary blood flow; Obesity; Cardiac function; Hemorrhage
ID CORONARY MICROVASCULAR DYSFUNCTION; TACHYCARDIA-INDUCED CARDIOMYOPATHY;
   MYOCARDIAL BLOOD-FLOW; DIASTOLIC DYSFUNCTION; OXYGEN-CONSUMPTION;
   METABOLIC SYNDROME; JUVENILE OBESITY; SKELETAL-MUSCLE; NATIONAL HEART;
   MODEL
AB The lack of pre-clinical large animal models of heart failure with preserved ejection fraction (HFpEF) remains a growing, yet unmet obstacle to improving understanding of this complex condition. We examined whether chronic cardiometabolic stress in Ossabaw swine, which possess a genetic propensity for obesity and cardiovascular complications, produces an HFpEF-like phenotype. Swine were fed standard chow (lean; n = 13) or an excess calorie, high-fat, high-fructose diet (obese; n = 16) for similar to 18 weeks with lean (n = 5) and obese (n = 8) swine subjected to right ventricular pacing (180 beats/min for similar to 4 weeks) to induce heart failure (HF). Baseline blood pressure, heart rate, LV end-diastolic volume, and ejection fraction were similar between groups. High-rate pacing increased LV end-diastolic pressure from similar to 11 +/- 1 mmHg in lean and obese swine to similar to 26 +/- 2 mmHg in lean HF and obese HF swine. Regression analyses revealed an upward shift in LV diastolic pressure vs. diastolic volume in paced swine that was associated with an similar to twofold increase in myocardial fibrosis and an similar to 50% reduction in myocardial capillary density. Hemodynamic responses to graded hemorrhage revealed an similar to 40% decrease in the chronotropic response to reductions in blood pressure in lean HF and obese HF swine without appreciable changes in myocardial oxygen delivery or transmural perfusion. These findings support that high-rate ventricular pacing of lean and obese Ossabaw swine initiates underlying cardiac remodeling accompanied by elevated LV filling pressures with normal ejection fraction. This distinct pre-clinical tool provides a unique platform for further mechanistic and therapeutic studies of this highly complex syndrome.
C1 [Tune, Johnathan D.; Dick, Gregory M.; Warne, Cooper M.; Tucker, Selina M.; Essajee, Salman, I] Univ North Texas, Dept Physiol & Anat, Hlth Sci Ctr, 3500 Camp Bowie Blvd, Ft Worth, TX 76107 USA.
   [Goodwill, Adam G.] Northeast Ohio Med Univ, Dept Integrat Med Sci, Rootstown, OH USA.
   [Baker, Hana E.] Eli Lilly & Co, Lilly Res Labs, Diabet & Complicat Res, Indianapolis, IN 46285 USA.
   [Bailey, Chastidy A.; Klasing, Jessica A.; Russell, Jacob J.; Bender, Shawn B.] Univ Missouri, Dept Biomed Sci, Columbia, MO USA.
   [Bailey, Chastidy A.; Klasing, Jessica A.; Russell, Jacob J.; Bender, Shawn B.] Harry S Truman Mem Vet Hosp, Res Serv, Columbia, MO 65201 USA.
   [McCallinhart, Patricia E.; Trask, Aaron J.] Nationwide Childrens Hosp, Ctr Cardiovasc Res, Abigail Wexner Res Inst, Columbus, OH USA.
   [Trask, Aaron J.] Ohio State Univ, Dept Pediat, Coll Med, Columbus, OH USA.
   [Bender, Shawn B.] Univ Missouri, Dalton Cardiovasc Res Ctr, Columbia, MO USA.
C3 University of North Texas System; University of North Texas Denton;
   University of North Texas Health Science Center; University System of
   Ohio; Northeast Ohio Medical University (NEOMED); Eli Lilly; Lilly
   Research Laboratories; University of Missouri System; University of
   Missouri Columbia; US Department of Veterans Affairs; Veterans Health
   Administration (VHA); Harry S. Truman Memorial Veterans' Hospital;
   University System of Ohio; Ohio State University; Nationwide Childrens
   Hospital; University System of Ohio; Ohio State University; University
   of Missouri System; University of Missouri Columbia
RP Tune, JD (corresponding author), Univ North Texas, Dept Physiol & Anat, Hlth Sci Ctr, 3500 Camp Bowie Blvd, Ft Worth, TX 76107 USA.
EM johnathan.tune@unthsc.edu
RI Dick, Gregory/HNR-4647-2023; Trask, Aaron/I-4076-2013; Goodwill,
   Adam/N-4889-2016
OI Tune, Johnathan/0000-0003-2959-0801; Goodwill, Adam/0000-0003-3701-3713;
   MCCALLINHART, PATRICIA/0009-0007-2138-7856; Tucker,
   Selina/0000-0002-7959-8716; Dick, Gregory/0000-0003-1444-6436
FU National Institutes of Health [R01 HL136386, R00 HL116769, R21
   EB026518]; Eli Lilly and Company; National Heart Lung and Blood
   Institute [R01HL136386] Funding Source: NIH RePORTER
FX This work was supported by the National Institutes of Health grants R01
   HL136386 (SBB), R00 HL116769 and R21 EB026518 (AJT) and by Eli Lilly and
   Company.
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NR 78
TC 4
Z9 4
U1 0
U2 5
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0300-8428
EI 1435-1803
J9 BASIC RES CARDIOL
JI Basic Res. Cardiol.
PD DEC
PY 2022
VL 117
IS 1
AR 50
DI 10.1007/s00395-022-00958-z
PG 15
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 5F7HL
UT WOS:000866482700001
PM 36222894
DA 2025-06-11
ER

PT J
AU Zhou, JL
   Wang, XY
   Liu, KY
   Chen, KY
AF Zhou, Jielin
   Wang, Xinyi
   Liu, Kaiyong
   Chen, Keyang
TI Association between Helicobacter pylori infection and the risk of
   type 2 diabetes mellitus based on a middle-aged and elderly Chinese
   population
SO ENDOCRINE JOURNAL
LA English
DT Article
DE Helicobacter pylori (Hp); Type 2 diabetes mellitus (T2DM); Joint effects
ID METABOLIC SYNDROME; PREVALENCE; OBESITY; INFLAMMATION; ERADICATION;
   PARAMETERS; RESISTANCE; STRESS
AB Evidence about the relationship between Helicobacter pylori (Hp) infection and type 2 diabetes mellitus (T2DM) is inconsistent and contradictory. This study attempted to investigate this association in the middle-aged and elderly Chinese population and analyze the joint effects of Hp infection and some risk factors on T2DM. Following a cross-sectional design, participants were recruited from the First Affiliated Hospital of Anhui Medical University in Hefei City, China. Hp status was measured using a C-14 urea breath test. A total of 1,288 participants, including 90 diabetic patients and 1,198 nondiabetic subjects, were recruited in the current study. The participants with T2DM had a greater prevalence of Hp infection than participants without T2DM (26.67% versus 18.11%, p = 0.045). Furthermore, we found that Hp infection was closely associated with an incremental risk of T2DM [odds ratio (OR) = 1.77, 95% confidence intervals (CI): 1.04-3.00] after adjustment for potential confounders. In addition, we observed that the participants who were Hp-positive and >= 60 years old (OR = 9.16, 95% CI: 3.29-25.52), Hp-positive and obese (OR = 3.35, 95% CI: 1.57-7.14) or Hp-positive and hypertensive (OR = 6.10, 95% CI: 3.10-12.01) had a significantly higher risk for T2DM than those who were Hp-negative and <= 50 years old, Hp-negative and nonobese or Hp-negative and nonhypertensive. These findings imply that Hp infection is associated with an increased risk of T2DM in the middle-aged and elderly Chinese population. The association could be further elevated by the combination of Hp infection and some traditional risk factors.
C1 [Zhou, Jielin; Liu, Kaiyong; Chen, Keyang] Anhui Med Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, 81 Meishan Rd, Hefei 230032, Anhui, Peoples R China.
   [Wang, Xinyi] Anhui Med Univ, Affiliated Hosp 1, Dept Radiol, Hefei 230022, Anhui, Peoples R China.
C3 Anhui Medical University; Anhui Medical University
RP Chen, KY (corresponding author), Anhui Med Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, 81 Meishan Rd, Hefei 230032, Anhui, Peoples R China.
EM chenkeyang98@163.com
RI Wang, Xinyi/HJH-9845-2023
FU National Natural Science Foundation of China [81570786]
FX This study was supported by the National Natural Science Foundation of
   China (Grant no.81570786 to KC).
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NR 45
TC 8
Z9 11
U1 0
U2 7
PU JAPAN ENDOCRINE SOC
PI KYOTO
PA 75  YANAGINOBANBA NISHIIRU-MASUYA-CHO, SANJOU-DORI, NAKAGYOU-KU, KYOTO,
   604-8111, JAPAN
SN 0918-8959
EI 1348-4540
J9 ENDOCR J
JI Endocr. J.
PY 2022
VL 69
IS 7
BP 839
EP 846
DI 10.1507/endocrj.EJ21-0591
EA FEB 2022
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 3J6RV
UT WOS:000758105200001
PM 35185091
OA gold
DA 2025-06-11
ER

PT J
AU Tabaeian, SP
   Mahmoudi, T
   Sabzikarian, M
   Rezamand, G
   Dabiri, R
   Nobakht, H
   Asadi, A
   Farahani, H
   Mansour-Ghanaei, F
   Zali, MR
AF Tabaeian, Seidamir Pasha
   Mahmoudi, Touraj
   Sabzikarian, Mohammad
   Rezamand, Gholamreza
   Dabiri, Reza
   Nobakht, Hossein
   Asadi, Asadollah
   Farahani, Hamid
   Mansour-Ghanaei, Fariborz
   Zali, Mohammad Reza
TI The Leu72Met (rs696217 G&gt;T) Polymorphism of the Ghrelin Gene Might Be
   a Protective Factor for Nonalcoholic Fatty Liver Disease
SO JOURNAL OF GASTROINTESTINAL AND LIVER DISEASES
LA English
DT Article
DE ghrelin; GHRL gene; GHSR gene; NAFLD; polymorphism
ID INSULIN-RESISTANCE; PLASMA GHRELIN; METABOLIC SYNDROME; CIRCULATING
   LEVELS; OXIDATIVE STRESS; ASSOCIATION; RECEPTOR; STEATOHEPATITIS;
   EPIDEMIOLOGY; PROGRESSION
AB Background & Aims: Nonalcoholic fatty liver disease (NAFLD) is a growing problem and the commonest cause of chronic liver disease throughout the world. Given the strong association between NAFLD and insulin resistance and obesity, as well as the central role of ghrelin in these metabolic disorders, we explored whether ghrelin (GHRL) and ghrelin receptor (GHSR) gene polymorphisms were associated with susceptibility to NAFLD.
   Methods: In this case-control retrospective study which was conducted between April 2010 and July 2013, GHRL (rs696217 or Leu72Met) and GHSR (rs2922126) gene polymorphisms were genotyped in 153 cases with biopsy-proven NAFLD and 157 controls using the polymerase chain reaction - restriction fragment length polymorphism method.
   Results: The GHRL rs696217 "GT+TT" genotype or "GT" genotype compared with the "GG" genotype occurred less frequently in the patients with NAFLD than the controls and the differences remained significant after adjustment for confounding factors such as age and body mass index (p=0.018; OR=0.35, 95%CI: 0.14-0.84 and p=0.046; OR=0.40, 95%CI: 0.16-0.98, respectively). Furthermore, the GHRL rs696217 'T' allele compared with 'G' allele was significantly underrepresented in the cases (p=0.007; OR=0.33, 95%CI: 0.15-0.76). Nevertheless, no significant difference was found for GHSR rs2922126 gene polymorphism.
   Conclusions: Our findings suggested, for the first time, that the GHRL rs696217 or Leu72Met "GT+TT" genotype and "GT" genotype compared with "GG" genotype, as well as the "T" or Met72 allele compared with "G" or Leu72 allele had a protective effect for NAFLD susceptibility. However, other studies are required to confirm these findings.
C1 [Tabaeian, Seidamir Pasha; Sabzikarian, Mohammad; Rezamand, Gholamreza] Iran Univ Med Sci, Colorectal Res Ctr, Tehran, Iran.
   [Mahmoudi, Touraj; Zali, Mohammad Reza] Shahid Beheshti Univ Med Sci, Res Inst Gastroenterol & Liver Dis, Gastroenterol & Liver Dis Res Ctr, Tehran 1985711151, Iran.
   [Dabiri, Reza; Nobakht, Hossein] Semnan Univ Med Sci, Internal Med Dept, Semnan, Iran.
   [Asadi, Asadollah] Univ Mohaghegh Ardabili, Dept Biol, Fac Sci, Ardebil, Iran.
   [Farahani, Hamid] Qom Univ Med Sci, Sch Med, Dept Physiol & Pharmacol, Qom, Iran.
   [Mansour-Ghanaei, Fariborz] Guilan Univ Med Sci, Div Gastroenterol & Hepatol, Gastrointestinal & Liver Dis Res Ctr GLDRC, Rasht, Iran.
C3 Iran University of Medical Sciences; Shahid Beheshti University Medical
   Sciences; Semnan University of Medical Sciences; University of Mohaghegh
   Ardabili; Guilan University of Medical Sciences
RP Mahmoudi, T (corresponding author), Shahid Beheshti Univ Med Sci, Res Inst Gastroenterol & Liver Dis, Gastroenterol & Liver Dis Res Ctr, Tehran 1985711151, Iran.
EM mahmouditouraj@gmail.com
RI Rezamand, Gholamreza/AAA-1105-2019; Karia, Mohammad/U-8210-2019;
   Mansour-Ghanaei, Fariborz/ABC-0170-2022; Nobakht, Hossein/AGP-1895-2022;
   Farahani, Hamid/ABD-4176-2021; Tabaeian, Seidamir/ABD-6654-2020; zali,
   mohammadreza/AAD-4452-2022; asadi, asadollah/M-6323-2016
OI Mahmoudi, Touraj/0000-0002-3220-6252; asadi,
   asadollah/0000-0003-3314-2948
FU Iran National Science Foundation (INSF) [90005942]; Gastroenterology and
   Liver Diseases Research Center, Shahid Beheshti University of Medical
   Sciences [1426]
FX The authors thank all patients and healthy blood donors for providing
   blood samples. This study was funded by the Iran National Science
   Foundation (INSF) [grant number 90005942] and the Gastroenterology and
   Liver Diseases Research Center, Shahid Beheshti University of Medical
   Sciences [grant number 1426].
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NR 57
TC 8
Z9 9
U1 0
U2 1
PU MEDICAL UNIV PRESS
PI CLUJ-NAPOCA
PA 3RD MEDICAL CLINIC, STR CROITORILOR NO 19-21, CLUJ-NAPOCA, 400162,
   ROMANIA
SN 1841-8724
EI 1842-1121
J9 J GASTROINTEST LIVER
JI J. Gastrointest. Liver Dis.
PD JUN
PY 2021
VL 30
IS 2
BP 233
EP 239
DI 10.15403/jgld-2703
PG 7
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA SV1BD
UT WOS:000663559800012
PM 34174062
OA gold
DA 2025-06-11
ER

PT J
AU Iacoviello, L
   Bonaccio, M
   de Gaetano, G
   Donati, MB
AF Iacoviello, Licia
   Bonaccio, Marialaura
   de Gaetano, Giovanni
   Donati, Maria Benedetta
TI Epidemiology of breast cancer, a paradigm of the "common soil"
   hypothesis
SO SEMINARS IN CANCER BIOLOGY
LA English
DT Review
DE Common soil; Epidemiology; Breast cancer; Dietary habits; Inflammation
ID C-REACTIVE PROTEIN; PLASMINOGEN-ACTIVATOR INHIBITOR; LOW-GRADE
   INFLAMMATION; MEDITERRANEAN DIET; CARDIOVASCULAR-DISEASE;
   MYOCARDIAL-INFARCTION; SOCIAL CONDITIONS; RISK-FACTORS; OBESITY; PAI-1
AB Breast cancer is the leading cause of death in women aged 20-50 years, with some geographical difference. The yearly incidence of the disease is increasing while the related mortality is steadily decreasing. Breast cancer is associated not only with specific hormones or factors related with reproduction, but mostly to more general environmental factors, linked to socioeconomic conditions and lifestyles (smoking, stress, physical exercise and particularly dietary habits). The latter, indeed, are risk factors or conditions common to hormone-dependent tumors and other chronic degenerative disorders, such as ischemic cardio cerebro-vascular and neurodegenerative disease. Breast cancer can indeed be considered as a paradigm of the so-called "common soil" concept, according to which the above mentioned conditions, although having different clinical manifestations, share some pathogenetic mechanisms and risk factors and intermediate predisposing phenotypes (see Type2 diabetes, metabolic syndrome or obesity). In an epidemiological perspective, evidence has been accumulated on the common response of breast cancer and cardiovascular disorders to healthy lifestyles and in particular to the beneficial effects of a close adhesion to the Mediterranean dietary model. The latter would mainly be effective thanks to its anti-inflammatory properties, thus controlling the subclinical condition of low-grade inflammation, a common risk factor of all the "common soil" disorders. Results from the prospective cohort of the Moli-sani Study (nearly 25,000 adults from the general population of the Southern Italy region of Molise) are highly suggestive in this context. In a public health perspective, the "common soil" hypothesis may thus promote the application of preventive strategies, particularly targeting lifestyles, for a broad spectrum of widely prevalent disorders, ranging from breast cancer to myocardial infarction or cognitive impairment conditions.
C1 [Iacoviello, Licia; Bonaccio, Marialaura; de Gaetano, Giovanni; Donati, Maria Benedetta] IRCCS Neuromed, Dept Epidemiol & Prevent, Via Elettron, I-86077 Pozzilli Is, Italy.
   [Iacoviello, Licia] Univ Insubria, Res Ctr Epidemiol & Prevent Med EPIMED, Dept Med & Surg, Varese Como, Italy.
C3 IRCCS Neuromed; University of Insubria
RP Iacoviello, L (corresponding author), IRCCS Neuromed, Dept Epidemiol & Prevent, Via Elettron, I-86077 Pozzilli Is, Italy.
EM lucia.iacoviello@uninsubria.it
RI Bonaccio, Marialaura/K-7678-2016; Donati, Maria/K-6606-2016; Iacoviello,
   Licia/AGX-7071-2022; Iacoviello, Licia/K-4676-2016
OI Iacoviello, Licia/0000-0003-0514-5885
FU Fondazione Umberto Veronesi Fellowship; Italian Ministry of Health
   [GR-2013-02356060]; Italian Association for Cancer Research (A.I.R.C.)
   [12237]; BiomarCaRE (Biomarkers for Cardiovascular Risk Assessment in
   Europe): European Commission Seventh Framework Programme FP7/2007-2013
   [HEALTH-F2-2011-278913]; POR CAMPANIA FESR 2014/2020 [459]
FX Marialaura Bonaccio was supported by a Fondazione Umberto Veronesi
   Fellowship. This work was partially supported by the Italian Ministry of
   Health (Young investigator grant to MB, number: GR-2013-02356060), the
   Italian Association for Cancer Research (A.I.R.C.) with grant AIRC
   "5x1000" to LI, Ref. n. 12237, BiomarCaRE (Biomarkers for Cardiovascular
   Risk Assessment in Europe): European Commission Seventh Framework
   Programme FP7/2007-2013 (HEALTH-F2-2011-278913) and by POR CAMPANIA FESR
   2014/2020 DA n.459, 27/11/2018.
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NR 94
TC 88
Z9 93
U1 0
U2 58
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 1044-579X
EI 1096-3650
J9 SEMIN CANCER BIOL
JI Semin. Cancer Biol.
PD JUL
PY 2021
VL 72
BP 4
EP 10
DI 10.1016/j.semcancer.2020.02.010
EA MAY 2021
PG 7
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Oncology
GA SE2FS
UT WOS:000651889400002
PM 32087245
DA 2025-06-11
ER

PT J
AU Posch-Pertl, L
   Michelitsch, M
   Wagner, G
   Wildner, B
   Silbernagel, G
   Pregartner, G
   Wedrich, A
AF Posch-Pertl, Laura
   Michelitsch, Monja
   Wagner, Gernot
   Wildner, Brigitte
   Silbernagel, Guenther
   Pregartner, Gudrun
   Wedrich, Andreas
TI Cholesterol and glaucoma: a systematic review and meta-analysis
SO ACTA OPHTHALMOLOGICA
LA English
DT Review
DE cholesterol; glaucoma; high-density lipoproteins; low-density
   lipoproteins; statins
ID NORMAL-TENSION GLAUCOMA; OPEN-ANGLE GLAUCOMA; C-REACTIVE PROTEIN;
   INTRAOCULAR-PRESSURE; METABOLIC SYNDROME; OCULAR HYPERTENSION; OXIDATIVE
   STRESS; RISK-FACTORS; ASSOCIATION; TIMOLOL
AB Purpose: Intraocular pressure is the main risk factor for glaucoma; however, additional risk factors may also matter. This systematic review and meta-analysis were conducted to summarize the evidence regarding the association of cholesterol parameters (total cholesterol, low-density lipoprotein (LDL) and high-density lipoprotein (HDL) levels) and glaucoma.
   Methods: Four electronic databases were searched for all publications containing 'glaucoma' and one of various forms of 'cholesterol' or 'lipoprotein'. Two independent reviewers screened abstracts and potentially full texts of identified articles for eligibility. Risk of bias was assessed with the Newcastle-Ottawa Scale. A random-effects meta-analysis was used to investigate the differences in total cholesterol, LDL and HDL levels between patients with and without glaucoma.
   Results: Overall, 29 observational studies were included in the systematic review and 26 reported quantitative information to investigate differences in cholesterol parameters between patients with glaucoma (N = 7196) and patients without glaucoma (N = 350 441). Patients with glaucoma had significantly higher total cholesterol levels than patients without glaucoma (Mean Difference (MD) 7.9 mg/dl, 95% CI 3.3 to 12.5, p = 0.001) and lower mean HDL levels (MD -2.0 mg/dl, 95% CI: -3.1 to -0.9, p = 0.001). Patients with glaucoma had higher mean LDL levels than patients without glaucoma, albeit not statistically significant (MD 6.1 mg/dl, 95% CI: -4.3 to 16.4, p = 0.251).
   Conclusion: This systematic review and meta-analysis of observational studies found an association of glaucoma and high total cholesterol and low HDL levels, respectively. Although this supports the hypothesis that lipid levels pose an additional risk for glaucoma development, heterogeneity was substantial and causality cannot be presumed from identified observational studies.
C1 [Posch-Pertl, Laura; Michelitsch, Monja; Wedrich, Andreas] Med Univ Graz, Dept Ophthalmol, Auenbruggerpl 4, A-8036 Graz, Austria.
   [Wagner, Gernot] Danube Univ Krems, Dept Evidence Based Med & Evaluat, Krems, Austria.
   [Wildner, Brigitte] Med Univ Vienna, Univ Lib, Vienna, Austria.
   [Silbernagel, Guenther] Med Univ Graz, Dept Internal Med, Div Angiol, Graz, Austria.
   [Silbernagel, Guenther] Charite, Campus Benjamin Franklin, Div Cardiol, Berlin, Germany.
   [Pregartner, Gudrun] Med Univ Graz, Inst Med Informat Stat & Documentat, Graz, Austria.
C3 Medical University of Graz; Danube University Krems; Medical University
   of Vienna; Medical University of Graz; Berlin Institute of Health; Free
   University of Berlin; Humboldt University of Berlin; Charite
   Universitatsmedizin Berlin; Medical University of Graz
RP Posch-Pertl, L (corresponding author), Med Univ Graz, Dept Ophthalmol, Auenbruggerpl 4, A-8036 Graz, Austria.
EM laura.pertl@medunigraz.at
OI Silbernagel, Guenther/0000-0001-9323-329X
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NR 43
TC 23
Z9 23
U1 1
U2 10
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1755-375X
EI 1755-3768
J9 ACTA OPHTHALMOL
JI Acta Ophthalmol.
PD MAR
PY 2022
VL 100
IS 2
BP 148
EP 158
DI 10.1111/aos.14769
EA JAN 2021
PG 11
WC Ophthalmology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Ophthalmology
GA YX9MP
UT WOS:000612339900001
PM 33506616
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Ruiz-Ramírez, A
   Barrios-Maya, M
   Quezada-Pablo, H
   López-Acosta, O
   El-Hafidi, M
AF Ruiz-Ramirez, Angelica
   Barrios-Maya, Miguel
   Quezada-Pablo, Hector
   Lopez-Acosta, Ocarol
   El-Hafidi, Mohammed
TI Kidney dysfunction induced by a sucrose-rich diet in rat involves
   mitochondria ROS generation, cardiolipin changes, and the decline of
   autophagy protein markers
SO AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
LA English
DT Article
DE autophagy; cardiolipin; cytochrome c; lipotoxicity; mitochondria
ID CYTOCHROME-C RELEASE; INITIATED METABOLIC SYNDROME; OXYGEN SPECIES
   PRODUCTION; FREE FATTY-ACIDS; PERMEABILITY TRANSITION; LIVER
   MITOCHONDRIA; INSULIN-RESISTANCE; HYDROGEN-PEROXIDE; OBESITY; HEART
AB The mechanistic link between obesity and renal failure has been proposed to involve mitochondria reactive oxygen species generation and lipotoxicity. These pathological conditions make mitochondria of particular interest in the regulation of cell function and death by both apoptosis and autophagy. Therefore, this work was undertaken to investigate mitochondria function. autophagy, and apoptosis protein markers in the kidney from a rat model of intra-abdominal obesity and renal damage induced by a high-sucrose diet. Mitochondria from sucrose-fed (SF) kidneys in the presence of pyruvate-malate generated H2O2 at a higher rate than from control (79.81 +/- 4.98 vs. 65.84 +/- 1.95 pmol.min(-1).mg protein(-1)). With succinate, the release of H2O2 was significantly higher compared with pyruvate-malate, and it remained higher in SF than in control mitochondria (146.4 +/- 8.8 vs. 106.1 +/- 5.9 pmol.min(-1).mg protein(-1)). However. cytochrome c release from SF kidney mitochondria was lower than from control. In addition, cardiolipin. a mitochondria-specific phospholipid. was found increased in SF mitochondria due to the enhanced amount of both cardiolipin synthase and tafazzin. Cardiolipin was also found enriched with saturated and monounsaturated fatty acids, which are less susceptible to peroxidative stress involved in cytochrome c release. Furthermore, beclin-1 and light chain 3-B, as autophagy protein markers, and caspase-9. as apoptosis protein marker, were found decreased in SF kidneys. These results suggest that the decline of autophagy protein markers and the lack of apoptosis process could be a pathological mechanism of cell dysfunction leading to the progression of renal disease in SF rats.
C1 [Ruiz-Ramirez, Angelica; Barrios-Maya, Miguel; Lopez-Acosta, Ocarol; El-Hafidi, Mohammed] Inst Nacl Cardiol Ignacio Chavez, Dept Biomed Cardiovasc, Juan Badiano 1,Colonia Secc 16, Mexico City 14080, DF, Mexico.
   [Quezada-Pablo, Hector] Hosp Infantil Mexico Dr Federico Gomez, Immunol & Prote Lab, Mexico City, DF, Mexico.
C3 National Institute of Cardiology - Mexico; Hospital Infantil de Mexico
   Federico Gomez
RP El-Hafidi, M (corresponding author), Inst Nacl Cardiol Ignacio Chavez, Dept Biomed Cardiovasc, Juan Badiano 1,Colonia Secc 16, Mexico City 14080, DF, Mexico.
EM medelhafidi@yahoo.com
RI El-Hafidi, Mohammed/AAN-4083-2021; Quezada, Hector/AAJ-8486-2021
OI Quezada, Hector/0000-0003-2663-4696
FU Consejo Nacional de Ciencia y Tecnologia [106845]
FX This work was supported in part by Consejo Nacional de Ciencia y
   Tecnologia Grant 106845.
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   Zhou D, 2016, LAB INVEST, V96, P156, DOI 10.1038/labinvest.2015.153
NR 68
TC 12
Z9 12
U1 0
U2 10
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 1931-857X
EI 1522-1466
J9 AM J PHYSIOL-RENAL
JI Am. J. Physiol.-Renal Physiol.
PD JAN
PY 2020
VL 318
IS 1
BP F53
EP F66
DI 10.1152/ajprenal.00208.2019
PG 14
WC Physiology; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology; Urology & Nephrology
GA KC9DP
UT WOS:000507471800006
PM 31657248
OA Bronze
DA 2025-06-11
ER

PT J
AU Zhu, JZ
   Hu, XY
   Dong, XY
   Li, LK
AF Zhu, Jingzhen
   Hu, Xiaoyan
   Dong, Xingyou
   Li, Longkun
TI Associations Between Risk Factors and Overactive Bladder: A
   Meta-analysis
SO FEMALE PELVIC MEDICINE AND RECONSTRUCTIVE SURGERY
LA English
DT Article
DE meta-analysis; overactive bladder; risk factor
ID QUALITY-OF-LIFE; URINARY-TRACT SYMPTOMS; POPULATION-BASED SURVEY;
   STRESS-INCONTINENCE; METABOLIC SYNDROME; CIGARETTE-SMOKING; URGE
   INCONTINENCE; NATURAL-HISTORY; STYLE FACTORS; PREVALENCE
AB Objective:The purpose of this study was to investigate the risk factors of overactive bladder (OAB).
   Methods: The PubMed, Embase, and Cochrane Library databases were retrieved through May 2016. Odds ratios (OR) or standard mean differences (SMDs) with 95% confidence intervals (CIs) were used to evaluate the associations between risk factors and OAB. Heterogeneity among studies was examined using chi(2) test based on the Q and I-2 tests.
   Results: A total of 28 articles were analyzed in our study. The results suggested that age and body mass index were significantly higher in OAB patients than in non-OAB controls (SMDs [95% CIs], 0.30 [0.19-0.41] and 0.39 [0.24-0.53]). A significant negative association was found between employment status and OAB (OR [95% CIs], 0.64 [0.46-0.90]). However, sex, educational level, parity, vaginal delivery, race, menopause, marital status, smoking, and alcohol consumption were not significantly different in OAB and non-OAB control patients (ORs [95% CIs], 0.95 [0.59-1.55], 1.04 [0.82, 1.33], 0.98 [0.56-1.70], 1.66 [0.90-3.07], 0.98 [0.75-1.28], 1.84 [0.23-14.70], 0.97 [0.78-1.19], 0.91 [0.77-1.08], and 0.88 [0.71-1.09], respectively). In addition, the number of parities and vaginal deliveries in OAB patients also showed no significant differences compared with non-OAB control patients (SMDs [95% CI], 0.05 [-0.27 to 0.38] and -0.16 [0.40 to 0.09]).
   Conclusions: This meta-analysis suggests that age and body mass index are associated with increased risks of OAB, whereas employment status is associated with a decreased risk of OAB. Further prospective studies with large sample sizes are needed to confirm this conclusion.
C1 [Zhu, Jingzhen; Hu, Xiaoyan; Dong, Xingyou; Li, Longkun] Third Mil Med Univ, Dept Urol, Affiliated Hosp 2, Chongqing 400037, Peoples R China.
C3 Army Medical University
RP Li, LK (corresponding author), Third Mil Med Univ, Dept Urol, Affiliated Hosp 2, Chongqing 400037, Peoples R China.
EM lilongk@hotmail.com
RI DONG, XINGYOU/HHZ-9016-2022
OI Dong, Xingyou/0000-0002-0901-8368; Li, Longkun/0000-0003-3939-5647; Zhu,
   Jingzhen/0000-0002-4978-6150
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NR 78
TC 34
Z9 38
U1 0
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 2151-8378
EI 2154-4212
J9 FEMALE PELVIC MED RE
JI Female Pelvic Med. Reconstr. Surg.
PD MAY-JUN
PY 2019
VL 25
IS 3
BP 238
EP 246
DI 10.1097/SPV.0000000000000531
PG 9
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA HY1TL
UT WOS:000467899900009
PM 29528879
OA Green Published
DA 2025-06-11
ER

PT J
AU Rodrigo, S
   Fauste, E
   de la Cuesta, M
   Rodríguez, L
   Alvarez-Millán, JJ
   Panadero, MI
   Otero, P
   Bocos, C
AF Rodrigo, Silvia
   Fauste, Elena
   de la Cuesta, Maite
   Rodriguez, Lourdes
   Alvarez-Millan, Juan J.
   Panadero, Maria I.
   Otero, Paola
   Bocos, Carlos
TI Maternal fructose induces gender-dependent changes in both LXRα promoter
   methylation and cholesterol metabolism in progeny
SO JOURNAL OF NUTRITIONAL BIOCHEMISTRY
LA English
DT Article
DE Fructose; Pregnancy; Fetal programming; Epigenetics; Cholesterol
ID DNA METHYLATION; PPAR-ALPHA; INDUCED DYSLIPIDEMIA; DIETARY FRUCTOSE;
   OXIDATIVE STRESS; PREGNANT RATS; PROTEIN; RISK; LACTATION; DISEASE
AB Fructose consumption from added sugars correlates with the epidemic rise in obesity, metabolic syndrome and cardiovascular diseases. However, consumption of beverages containing fructose is allowed during gestation. We have investigated whether maternal fructose intake produces subsequent changes in cholesterol metabolism of progeny. Carbohydrates were supplied to pregnant rats in drinking water (10% w/v solution) throughout gestation. Adult male and female descendants from fructose-fed, control or glucose-fed mothers were studied. Male offspring from fructose-fed mothers had elevated plasma HDL-cholesterol levels, whereas female progeny from fructose-fed mothers presented lower levels of non-HDL cholesterol vs. the other two groups. Liver X-receptor (LXR), an important regulator of cholesterol metabolism, and its target genes such as scavenger receptor BI, ATP-binding cassette (ABC)G5 and cholesterol 7-alpha hydroxylase showed decreased gene expression in males from fructose-fed mothers and the opposite in the female progeny. Moreover, the expression of a number of LXR alpha target genes related to lipogenesis paralleled to that for LXR alpha expression. In accordance with this, LXR alpha gene promoter methylation was increased in males from fructose-fed mothers and decreased in the corresponding group of females. Surprisingly, plasma folic acid levels, an important methyl-group donor, were augmented in males from fructose-fed mothers and diminished in female offspring. Maternal fructose intake produces a fetal programming that influences, in a gender-dependent manner, the transcription factor LXR alpha epigenetically, and both hepatic mRNA gene expression and plasma parameters of cholesterol metabolism in adult progeny. Changes in the LXR alpha promoter methylation might be related to the availability of the methyl donor folate. (C) 2018 Elsevier Inc. All rights reserved.
C1 [Rodrigo, Silvia; Fauste, Elena; de la Cuesta, Maite; Rodriguez, Lourdes; Panadero, Maria I.; Otero, Paola; Bocos, Carlos] Univ San Pablo CEU, Fac Farm, CEU Univ, Monteprincipe, Madrid, Spain.
   [Alvarez-Millan, Juan J.] CQS Lab, Madrid, Spain.
C3 San Pablo CEU University
RP Bocos, C (corresponding author), Univ San Pablo CEU, Fac Farm, CEU Univ, Urbanizac Monteprincipe, Madrid 28668, Spain.
EM carbocos@ceu.es
RI Otero, Paola/H-9150-2015; Fauste, Elena/AAT-8282-2020; BOCOS,
   CARLOS/B-8460-2015; Panadero, Maria I./L-4262-2017
OI Alvarez Millan, Juan Jose/0000-0002-6774-4958; BOCOS,
   CARLOS/0000-0003-0364-5958; Fauste, Elena/0000-0002-5783-3092; Panadero,
   Maria I./0000-0003-0459-3539
FU Ayuda a Grupo en Consolidation from Universidad San Pablo-CEU; Banco de
   Santander [USP-BS-PCON02/2016]; Fundacion Espanola de
   Arteriosclerosis/Sociedad Espanola de Arteriosclerosis (FEA/SEA);
   FUSP-CEU fellowship; FPU fellowship from Ministerio de Education,
   Cultura y Deporte
FX The authors thank Jose M. Garrido and his team for their help in
   handling the rats, and Brian Crilly for his editorial help. This work
   was supported by grants from the Ayuda a Grupo en Consolidation from
   Universidad San Pablo-CEU and Banco de Santander (USP-BS-PCON02/2016),
   and "Manuel de Oya" Award for Nutrition Research 2016 from Fundacion
   Espanola de Arteriosclerosis/Sociedad Espanola de Arteriosclerosis
   (FEA/SEA). Silvia Rodrigo was supported with a FUSP-CEU fellowship.
   Elena Fauste is supported with a FPU fellowship from Ministerio de
   Education, Cultura y Deporte.
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NR 65
TC 21
Z9 21
U1 0
U2 8
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0955-2863
EI 1873-4847
J9 J NUTR BIOCHEM
JI J. Nutr. Biochem.
PD NOV
PY 2018
VL 61
BP 163
EP 172
DI 10.1016/j.jnutbio.2018.08.011
PG 10
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA HC4RE
UT WOS:000451791100017
PM 30236873
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Shao, WT
   Liu, Q
   He, XW
   Liu, H
   Gu, AH
   Jiang, ZY
AF Shao, Wentao
   Liu, Qian
   He, Xiaowei
   Liu, Hui
   Gu, Aihua
   Jiang, Zhaoyan
TI Association between level of urinary trace heavy metals and obesity
   among children aged 6-19 years: NHANES 1999-2011
SO ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
LA English
DT Article
DE Trace heavy metal; Obesity; Children; Urine; National Health and
   Nutrition Examination Survey
ID METABOLIC SYNDROME; CADMIUM; HEALTH; CHILDHOOD; EXPOSURE; STRESS;
   COBALT; CONSEQUENCES; PREVALENCE; ELEMENTS
AB Global prevalence of obesity has been increasing dramatically in all ages. Although traditional causes for obesity development have been studied widely, it is unclear whether environmental exposure of substances such as trace heavy metals affects obesity development among children and adolescents so far. Data from the National Health and Nutrition Examination Survey (1999-2011)were retrieved, and 6602 US children were analyzed in this study. Urinary level of nine trace heavy metals, including barium, cadmium, cobalt, cesium, molybdenum, lead, antimony, thallium, and tungsten, was analyzed for their association with the prevalence of obesity among children aged 6-19 years. Multiple logistic regression was performed to assess the associations adjusted for age, race/ethnicity, gender, urinary creatinine, PIR, serum cotinine, and television, video game, and computer usage. A remarkable association was found between barium exposure (OR 1.43; 95% CI 1.09-1.88; P < 0.001) and obesity in children aged 6-19 years. Negative association was observed between cadmium (OR 0.46; 95% CI 0.33-0.64; P < 0.001), cobalt (OR 0.56; 95% CI: 0.41-0.76; P < 0.001), and lead (OR 0.57; 95% CI 0.41-0.78; P = 0.018), and obesity. All the negative associations were stronger in the 6-12 years group than in the 13-19 years group. The present study demonstrated that barium might increase the occurrence of obesity, but cadmium, cobalt, and lead caused weight loss among children. The results imply that trace heavy metals may represent critical risk factors for the development of obesity, especially in the area that the state of metal contamination is serious.
C1 [Shao, Wentao; Jiang, Zhaoyan] Tongji Univ, Sch Med, Ctr Gallbladder Dis, Shanghai East Hosp, 150 Jimo Rd, Shanghai 201200, Peoples R China.
   Nanjing Med Univ, Inst Toxicol, State Key Lab Reprod Med, 818 East Tianyuan Rd, Nanjing 211166, Jiangsu, Peoples R China.
   [Shao, Wentao; Liu, Qian; He, Xiaowei; Liu, Hui; Gu, Aihua] Nanjing Med Univ, Key Lab Modern Toxicol, Sch Publ Hlth, Minist Educ, 818 East Tianyuan Rd, Nanjing, Jiangsu, Peoples R China.
C3 Tongji University; Nanjing Medical University; Ministry of Education -
   China; Nanjing Medical University
RP Jiang, ZY (corresponding author), Tongji Univ, Sch Med, Ctr Gallbladder Dis, Shanghai East Hosp, 150 Jimo Rd, Shanghai 201200, Peoples R China.; Gu, AH (corresponding author), Nanjing Med Univ, Key Lab Modern Toxicol, Sch Publ Hlth, Minist Educ, 818 East Tianyuan Rd, Nanjing, Jiangsu, Peoples R China.
EM aihuagu@njmu.edu.cn; zhaoyanjiang@gmail.com
RI shao, wentao/GWR-0572-2022; He, XW/JXN-0620-2024
FU National Natural Science Foundation of China [81270537, 81570574,
   81573174]; Outstanding Youth Fund of Jiangsu Province [SBK2014010296];
   Research Project of Chinese Ministry of Education [213015A]; Priority
   Academic Program Development of Jiangsu Higher Education Institutions;
   Flagship Major Development of Jiangsu Higher Education Institutions;
   Open Project Program of the State Key Laboratory of Environmental
   Chemistry and Ecotoxicology [KF2015-01]
FX This work was supported by the National Natural Science Foundation of
   China (Grant Nos. 81270537, 81570574, and 81573174), the Outstanding
   Youth Fund of Jiangsu Province (SBK2014010296), the Research Project of
   Chinese Ministry of Education (213015A), the Priority Academic Program
   Development of Jiangsu Higher Education Institutions, the Flagship Major
   Development of Jiangsu Higher Education Institutions, and the Open
   Project Program of the State Key Laboratory of Environmental Chemistry
   and Ecotoxicology (KF2015-01).
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NR 43
TC 82
Z9 93
U1 2
U2 44
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0944-1344
EI 1614-7499
J9 ENVIRON SCI POLLUT R
JI Environ. Sci. Pollut. Res.
PD APR
PY 2017
VL 24
IS 12
BP 11573
EP 11581
DI 10.1007/s11356-017-8803-1
PG 9
WC Environmental Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology
GA ES3AP
UT WOS:000399399700064
PM 28321702
DA 2025-06-11
ER

PT J
AU Becerra, AZ
   Georas, S
   Brenna, JT
   Hopke, PK
   Kane, C
   Chalupa, D
   Frampton, MW
   Block, R
   Rich, DQ
AF Becerra, Adan Z.
   Georas, Steve
   Brenna, J. Thomas
   Hopke, Philip K.
   Kane, Cathleen
   Chalupa, David
   Frampton, Mark W.
   Block, Robert
   Rich, David Q.
TI Increases in ambient particulate matter air pollution, acute changes in
   platelet function, and effect modification by aspirin and omega-3 fatty
   acids: A panel study
SO JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES
LA English
DT Article
ID MYOCARDIAL-INFARCTION; FISH-OIL; LYSOPHOSPHATIDIC ACIDS; ULTRAFINE
   PARTICLES; HOSPITAL ADMISSIONS; METABOLIC SYNDROME; OXIDATIVE STRESS;
   CASE-CROSSOVER; INFLAMMATION; ASSOCIATION
AB Increased particulate matter (PM) air pollutant concentrations have been associated with platelet activation. It was postulated that elevated air pollutant concentrations would be associated with increases in measures of platelet function and that responses would be blunted when taking aspirin and/or fish oil. Data from a sequential therapy trial (30 subjects with type 2 diabetes mellitus), with 4 clinic visits (first: no supplements, second: aspirin, third: omega-3 fatty acid supplements, fourth: aspirin and omega-3 fatty acids) per subject, were utilized. Using linear mixed models, adjusted for relative humidity, temperature, visit number, and season, changes in three platelet function measures including (1) aggregation induced by adenosine diphosphate (ADP), (2) aggregation induced by collagen, and (3) thromboxane B2 production were associated with interquartile range (IQR) increases in mean concentrations of ambient PM2.5, black carbon, ultrafine particles (UFP; 10-100 nm), and accumulation mode particles (AMP; 100-500 nm) in the previous 1-96 h. IQR increases in mean UFP and AMP concentrations were associated with significant decreases in platelet response, with the largest being a -0.43 log(pg/ml) decrease in log(thromboxane B2) (95% CI = -0.8, -0.1) associated with each 582-particles/cm(3) increase in AMP, and a -1.7 ohm reduction in collagen-induced aggregation (95% CI = -3.1, -0.3) associated with each 2097-particles/cm(3) increase in UFP in the previous 72 h. This UFP effect on thromboxane B2 was significantly muted in diabetic subjects taking aspirin (-0.01 log[pg/ml]; 95% CI = -0.4, 0.3). The reason for this finding remains unknown, and needs to be investigated in future studies.
C1 [Becerra, Adan Z.; Kane, Cathleen; Block, Robert; Rich, David Q.] Univ Rochester, Sch Med & Dent, Dept Publ Hlth Sci, 265 Crittenden Blvd,CU 420644, Rochester, NY 14642 USA.
   [Georas, Steve; Chalupa, David; Frampton, Mark W.] Univ Rochester, Sch Med & Dent, Dept Med, Div Pulm & Crit Care Med, Rochester, NY 14642 USA.
   [Georas, Steve; Chalupa, David; Frampton, Mark W.; Rich, David Q.] Univ Rochester, Sch Med & Dent, Dept Environm Med, Rochester, NY 14642 USA.
   [Brenna, J. Thomas] Cornell Univ, Div Nutr Sci, Ithaca, NY 14853 USA.
   [Hopke, Philip K.] Clarkson Univ, Inst Sustainable Environm, Potsdam, NY USA.
C3 University of Rochester; University of Rochester; University of
   Rochester; Cornell University; Clarkson University
RP Rich, DQ (corresponding author), Univ Rochester, Sch Med & Dent, Dept Publ Hlth Sci, 265 Crittenden Blvd,CU 420644, Rochester, NY 14642 USA.
EM david_rich@urmc.rochester.edu
RI Brenna, Tom/A-4167-2008; Hopke, Philip/C-6020-2008
OI Rich, David/0000-0001-7132-0069; Hopke, Philip/0000-0003-2367-9661;
   Chalupa, David/0000-0002-8329-3640; Brenna, James
   Thomas/0000-0001-9494-4245
FU National Heart Lung and Blood Institute (NHLBI) [5R21HL102582-02];
   University of Rochester CTSA award from the National Center for Research
   Resources [KL2 RR024136]; National Center for Advancing Translational
   Sciences of the National Institutes of Health (NIH); NIH [R01 HL071933,
   R21 ES023032, P30 ES001247]
FX The authors thank the study participants. This publication was supported
   by National Heart Lung and Blood Institute (NHLBI) grant
   5R21HL102582-02, the University of Rochester CTSA award KL2 RR024136
   from the National Center for Research Resources, and the National Center
   for Advancing Translational Sciences of the National Institutes of
   Health (NIH). Other support from the NIH was provided by R01 HL071933,
   R21 ES023032, and P30 ES001247. The content is solely the responsibility
   of the authors and does not necessarily represent the official views of
   the NHLBI, National Institute of Environmental Health Sciences (NIEHS),
   or NIH. Robert Block and David Q. Rich contributed equally to this work
   as senior authors.
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NR 54
TC 16
Z9 20
U1 0
U2 17
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1528-7394
EI 1087-2620
J9 J TOXICOL ENV HEAL A
JI J. Toxicol. Env. Health Part A
PY 2016
VL 79
IS 6
BP 287
EP 298
DI 10.1080/15287394.2016.1157539
PG 12
WC Environmental Sciences; Public, Environmental & Occupational Health;
   Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health; Toxicology
GA DO9OY
UT WOS:000378117300004
PM 27029326
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Otto, MCCD
   Alonso, A
   Lee, DH
   Delclos, GL
   Jenny, NS
   Jiang, R
   Lima, JA
   Symanski, E
   Jacobs, DR
   Nettleton, JA
AF Otto, Marcia C. C. de Oliveira
   Alonso, Alvaro
   Lee, Duk-Hee
   Delclos, George L.
   Jenny, Nancy S.
   Jiang, Rui
   Lima, Joao A.
   Symanski, Elaine
   Jacobs, David R., Jr.
   Nettleton, Jennifer A.
TI Dietary Micronutrient Intakes Are Associated with Markers of
   Inflammation but Not with Markers of Subclinical Atherosclerosis
SO JOURNAL OF NUTRITION
LA English
DT Article
ID CORONARY-HEART-DISEASE; CARDIOVASCULAR-DISEASE; INSULIN-RESISTANCE;
   OXIDATIVE STRESS; METABOLIC SYNDROME; ENDOTHELIAL DYSFUNCTION; SYSTEMIC
   INFLAMMATION; MAGNESIUM INTAKE; ASCORBIC-ACID; RISK
AB Few studies have examined associations of dietary micronutrients with markers of inflammation and subclinical atherosclerosis. The present study investigated associations of heme iron, nonheme iron, zinc (Zn), magnesium (Mg), beta-carotene, vitamin C, and vitamin E with C-reactive protein (CRP), IL-6, total homocysteine (tHcy), fibrinogen, coronary artery calcium, and common and internal carotid artery intima media thickness. Micronutrient intakes and markers of inflammation and subclinical atherosclerosis were studied in 5181 participants from the Multi-Ethnic Study of Atherosclerosis who were aged 45-84 y and free of diabetes and cardiovascular disease. Models were adjusted for energy intake, demographics, lifestyle characteristics, and BM I. Dietary nonheme iron and Mg intakes were inversely associated with tHcy concentrations (mean tHcy: 9.11, 8.86, 8.74, 8.71, and 8.50 mu mol/L, and 9.20, 9.00, 8.65, 8.76, and 8.33 mu mol/L across increasing quintiles of nonheme iron and Mg, respectively; P-trend < 0.001 for both). However, dietary Zn and heme iron were positively associated with CRP [mean: 1.73, 1.75, 1.78, 1.88, and 1.96 mg/L across increasing quintiles of Zn and 1.72, 1.76, 1.83, 1.86, and 1.94 mg/L across increasing quintiles of heme iron (P-trend = 0.002 and 0.01, respectively). Other tested micronutrient-marker associations were not significant. In conclusion, of the 49 tested associations, only 7 were significant. Although this study does not provide strong support for associations between the micronutrients and markers of inflammation and subclinical atherosclerosis, the results are consistent with dietary guidelines that advocate for a balanced diet that includes a variety of plant foods containing Mg, Zn, and nonheme iron. J. Nutr. 141: 1508-1515, 2011.
C1 [Otto, Marcia C. C. de Oliveira; Delclos, George L.; Symanski, Elaine; Nettleton, Jennifer A.] Univ Texas Houston, Sch Publ Hlth, Div Epidemiol Human Genet & Environm Sci, Houston, TX 77030 USA.
   [Alonso, Alvaro; Jacobs, David R., Jr.] Univ Minnesota, Div Epidemiol & Community Hlth, Minneapolis, MN 55454 USA.
   [Lee, Duk-Hee] Kyungpook Natl Univ, Seoul 700422, South Korea.
   [Jenny, Nancy S.] Univ Vermont, Coll Med, Dept Pathol, Burlington, VT 05446 USA.
   [Jiang, Rui] Columbia Univ, Coll Phys & Surg, Dept Med, New York, NY 10032 USA.
   [Jiang, Rui] Columbia Univ, Mailman Sch Publ Hlth, Dept Epidemiol, New York, NY 10032 USA.
   [Lima, Joao A.] Johns Hopkins Univ, Dept Cardiol, Baltimore, MD 21205 USA.
C3 University of Texas System; University of Texas Health Science Center
   Houston; University of Texas School Public Health; University of
   Minnesota System; University of Minnesota Twin Cities; Kyungpook
   National University (KNU); University of Vermont; Columbia University;
   Columbia University; Johns Hopkins University
RP Nettleton, JA (corresponding author), Univ Texas Houston, Sch Publ Hlth, Div Epidemiol Human Genet & Environm Sci, Houston, TX 77030 USA.
EM Jennifer.A.Nettleton@uth.tmc.edu
RI ALONSO GOMEZ, ANGEL/HLG-2476-2023; Jacobs, David/G-5405-2011; Alonso,
   Alvaro/A-4917-2010
OI Alonso, Alvaro/0000-0002-2225-8323; Jacobs, David/0000-0002-7232-0543
FU National Institute of Diabetes and Digestive and Kidney Diseases
   [5K01DK082729-02]; National Heart, Lung, and Blood Institute
   [N01-HC-95159, N01-HC-95166]; NIH, National Institute of Diabetes and
   Digestive and Kidney Diseases [5K01DK082729-02, K01]
FX Supported by National Institute of Diabetes and Digestive and Kidney
   Diseases (5K01DK082729-02 to Dr. Nettleton) and contracts N01-HC-95159
   through N01-HC-95166 from the National Heart, Lung, and Blood Institute.
   Dr. Nettleton is supported by a K01 from the NIH, National Institute of
   Diabetes and Digestive and Kidney Diseases (5K01DK082729-02).
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NR 54
TC 88
Z9 91
U1 0
U2 6
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0022-3166
EI 1541-6100
J9 J NUTR
JI J. Nutr.
PD AUG
PY 2011
VL 141
IS 8
BP 1508
EP 1515
DI 10.3945/jn.111.138115
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 796KE
UT WOS:000293049400015
PM 21653577
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Bouchard-Mercier, A
   Godin, G
   Lamarche, B
   Pérusse, L
   Vohl, MC
AF Bouchard-Mercier, Annie
   Godin, Gaston
   Lamarche, Benoit
   Perusse, Louis
   Vohl, Marie-Claude
TI Effects of Peroxisome Proliferator-Activated Receptors, Dietary Fat
   Intakes and Gene-Diet Interactions on Peak Particle Diameters of
   Low-Density Lipoproteins
SO JOURNAL OF NUTRIGENETICS AND NUTRIGENOMICS
LA English
DT Article
DE Dietary fat; Gene polymorphisms; Low-density lipoprotein; Particle
   diameters; Peroxisome proliferator-activated receptors; PPAR alpha; PPAR
   delta; PPAR gamma
ID CORONARY-HEART-DISEASE; GAMMA GENE; METABOLIC SYNDROME; SATURATED FAT;
   PPAR-ALPHA; LDL SIZE; POLYMORPHISM; ACIDS; CHOLESTEROL; RISK
AB The risk of cardiovascular diseases (CVDs) is modulated by gene diet interactions. The objective of this study was to examine whether gene diet interactions affect peak particle diameters (PPD) of low-density lipoprotein (LDL). Methods: The study included 674 participants. A food frequency questionnaire was administered to obtain dietary information. LDL-PPD was determined by non-denaturing 2-16% polyacrylamide gradient gel electrophoresis. Peroxisome proliferator-activated receptor (PPAR) gene polymorphisms PPAR alpha L162V (rs1800206), PPAR-gamma P12A (rs1801282) and PPAR delta-87T -> C (rs2016520) were determined by PCR-RFLP. Results: Among carriers of the PPARa L162V polymorphism, gene diet interaction effects on LDL-PPD were observed with saturated fat (p = 0.0005) and total dietary fat (p = 0.006). Among PPAR alpha V162 carriers, subjects with higher saturated fat intakes had smaller LDL-PPD than those with lower intakes (254.23 +/- 2.74 vs. 256.21 +/- 2.61 A, respectively, p = 0.007). Among subjects homozygous for the PPAR alpha L162 allele, those with higher saturated fat intakes had larger LDL-PPD than those with lower saturated fat intakes (255.86 +/- 2.66 vs. 255.05 +/- 2.65 A, respectively, p = 0.01). Gene diet interactions were also found for PPAR gamma P12A polymorphism with saturated fat intake (p = 0.04) and for PPAR delta -87T -> C with the polyunsaturated/saturated fat ratio (p = 0.0013). Conclusions: These results stress that dietary factors should be included in studies determining the effect of different polymorphisms on CVD risk factors. Copyright (C) 2011 S. Karger AG, Basel
C1 [Bouchard-Mercier, Annie; Lamarche, Benoit; Perusse, Louis; Vohl, Marie-Claude] Univ Laval, Inst Nutraceut & Funct Foods, Quebec City, PQ G1K 7P4, Canada.
   [Bouchard-Mercier, Annie; Lamarche, Benoit; Vohl, Marie-Claude] Univ Laval, Dept Food Sci & Nutr, Quebec City, PQ G1K 7P4, Canada.
   [Godin, Gaston] Univ Laval, Fac Nursing, Quebec City, PQ G1K 7P4, Canada.
   [Perusse, Louis] Univ Laval, Dept Social & Prevent Med, Div Kinesiol, Quebec City, PQ G1K 7P4, Canada.
C3 Laval University; Laval University; Laval University; Laval University
RP Vohl, MC (corresponding author), Univ Laval, INAF, 2440 Blvd Hochelaga,Pavillon Serv,Local 2729K, Quebec City, PQ G1K 7P4, Canada.
EM marie-claude.vohl@fsaa.ulaval.ca
RI Vohl, Marie-Claude/AAQ-1378-2021; Lamarche, Benoit/ABA-4785-2021;
   Perusse, Louis/A-3444-2012
OI Lamarche, Benoit/0000-0002-4443-5378; Vohl,
   Marie-Claude/0000-0002-7017-5848; Perusse, Louis/0000-0001-6440-9698
FU Fonds de recherche en sante du Quebec; Canadian Institutes of Health
   Research [OHN 63276]
FX Annie Bouchard-Mercier is supported by the master's award from the Fonds
   de recherche en sante du Quebec. This work was supported by a grant from
   the Canadian Institutes of Health Research-New Emerging Team Program
   (OHN 63276).
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NR 53
TC 24
Z9 25
U1 0
U2 4
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1661-6499
EI 1661-6758
J9 J NUTRIGENET NUTRIGE
JI J. Nutrigenet. Nutrigenomics
PY 2011
VL 4
IS 1
BP 36
EP 48
DI 10.1159/000324531
PG 13
WC Genetics & Heredity; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Genetics & Heredity; Nutrition & Dietetics
GA 766JD
UT WOS:000290777500005
PM 21487230
OA gold
DA 2025-06-11
ER

PT J
AU Romero, MD
   Vilá, R
   Fernández-López, JA
   Esteve, M
   Alemany, M
AF del Mar Romero, Maria
   Vila, Ruth
   Antonio Fernandez-Lopez, Jose
   Esteve, Montserrat
   Alemany, Maria
TI Oleoyl-estrone increases adrenal corticosteroid synthesis gene
   expression in overweight male rats
SO STEROIDS
LA English
DT Article
DE Overweight; Adrenal glands; Glucocorticoids; Corticosterone synthesis;
   Oleoyl-estrone; Pair-feeding
ID ZUCKER OBESE RATS; 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1;
   SHORT-TERM TREATMENT; METABOLIC SYNDROME; ADIPOSE-TISSUE;
   ADRENALECTOMIZED RATS; LIPOSOMES MERLIN-2; INSULIN-RESISTANCE; OXIDATIVE
   STRESS; BODY-WEIGHT
AB Oleoyl-estrone (CE) induces a marked loss of body fat in rats by maintaining energy expenditure, body protein and blood glucose despite decreasing food intake. OE increases glucocorticoids, but they arrest OE lipid-mobilization. We studied here whether OE induces a direct effect on adrenal glands function as part of this feedback regulation. Dietary overweight male rats were given oral 10 nmol/g OE gavages for ten days. A group (PF) of pair-fed to OE rats, and controls received vehicle-only gavages. OE rats lost slightly more body than PF, but had larger adrenal glands. Tissue corticosterone levels, and gene expressions for glucocorticoid-synthesizing enzymes were increased in OE versus controls and PF; thus, we assumed that adrenal growth affected essentially its cortex since OE also lowered the expression of the medullar catecholamine synthesis enzyme genes. Serum corticosterone was higher in PF than in OE and controls, but liver expression of corticosteroid-disposing steroid 5(x-reductase was 3 x larger in OE than PF and controls. Circulating glucocorticoids changed little under OE, in spite of higher adrenal gland and liver content, hinting at modulation of glucocorticoid turnover as instrumental in their purported increased activity. In conclusion, we have observed that OE considerable enhanced the expression of the genes controlling the synthesis of glucocorticoids from cholesterol in the rat and increasing the adrenal glands' corticosterone, size and cellularity, but also the liver disposal of corticosteroids, suggesting that OE increases corticosterone synthesis and degradation (i.e. serum turnover), a process not driven by limited energy availability but directly related to the administration of OE. (C) 2009 Elsevier Inc. All rights reserved.
C1 [del Mar Romero, Maria; Vila, Ruth; Antonio Fernandez-Lopez, Jose; Esteve, Montserrat; Alemany, Maria] Univ Barcelona, Fac Biol, Dept Nutr & Food Sci, E-08028 Barcelona, Spain.
   [del Mar Romero, Maria; Vila, Ruth; Antonio Fernandez-Lopez, Jose; Esteve, Montserrat; Alemany, Maria] Inst Hlth Carlos III, CIBER Obes & Nutr, Barcelona, Spain.
C3 University of Barcelona; CIBER - Centro de Investigacion Biomedica en
   Red; CIBEROBN
RP Alemany, M (corresponding author), Univ Barcelona, Fac Biol, Dept Nutr & Food Sci, Av Diagonal 645, E-08028 Barcelona, Spain.
EM marromero@ub.edu; vila@ub.edu; josfernandez@ub.edu; mesteve@ub.edu;
   malemany@ub.edu
RI Romero, Maria del Mar/K-9004-2017; Esteve, Montserrat/L-6272-2014;
   Alemany, Maria/H-5224-2011; Fernandez-Lopez, Jose-Antonio/C-5467-2017
OI Romero, Maria del Mar/0000-0001-6274-5743; Esteve,
   Montserrat/0000-0003-2128-7859; Alemany, Maria/0000-0002-9783-8293;
   Fernandez-Lopez, Jose-Antonio/0000-0002-2856-7223
FU Government of Spain [PI052179, SAF2006-05134]
FX The financial and material help of OED S.L. for the development of this
   study, and the contributions of CIBER Fisiopatologia de la Obesidad y
   Nutricion of the Spanish Institute of Health Carlos III are gratefully
   acknowledged. Grants: PI052179 Fondo de Investigaciones Sanitarias;
   SAF2006-05134 Plan Nacional de Investigacion en Biomedicina, both from
   the Government of Spain.
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NR 59
TC 4
Z9 4
U1 0
U2 4
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0039-128X
EI 1878-5867
J9 STEROIDS
JI Steroids
PD JAN
PY 2010
VL 75
IS 1
BP 20
EP 26
DI 10.1016/j.steroids.2009.09.009
PG 7
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 549VS
UT WOS:000274083000003
PM 19793540
DA 2025-06-11
ER

PT J
AU Nwaiwu, J
   Ibeh, S
   Reslan, MA
   Bakkar, NMZ
   Nasrallah, L
   Eid, AH
   Mekhjian, S
   Sanni, A
   Haidar, MA
   Goli, M
   Obeid, O
   El Khoury, R
   Mechref, Y
   El-Yazbi, AF
   Kobeissy, F
AF Nwaiwu, Judith
   Ibeh, Stanley
   Reslan, Mohammad Amine
   Bakkar, Nour-Mounira Z.
   Nasrallah, Leila
   Eid, Ali H.
   Mekhjian, Sarin
   Sanni, Akeem
   Haidar, Muhammad Ali
   Goli, Mona
   Obeid, Omar
   El Khoury, Riyad
   Mechref, Yehia
   El-Yazbi, Ahmed F.
   Kobeissy, Firas
TI Western diet induces mild metabolic impairment and aggravates
   neuropathology in an experimental mouse model of traumatic brain injury
SO JOURNAL OF NEURORESTORATOLOGY
LA English
DT Article
DE Traumatic brain injury; Western diet; Mild metabolic impairment;
   Neuroinflammation
ID MITOCHONDRIA; DYSFUNCTION; PLASTICITY; STRESS; WINDOW; MICE
AB Traumatic brain injury (TBI) and lifestyle habits such as Western diet (WD) consumption represent two risk factors that affect an individual's health outcome globally. Individuals with TBI have a greater risk of mortality from associated chronic diseases than the general population. WD has been shown to impair cognitive function, decrease the brain's capacity to compensate for insult by affecting recovery as well as induce metabolic syndrome (MetS) which may be a risk factor for poor TBI prognosis. Hence, this study aims to investigate the impact of WD on TBI behavioral outcomes and neuropathology. Eight-week-old male C57BL6 mice were fed either WD or normal chow for 4 weeks prior to TBI induction. At week four, mice underwent either an experimental open-head TBI or a sham procedure. Mice continued their respective diets for four weeks after brain injury. Metabolic, cognitive function, and molecular assessment were performed four weeks after TBI. Results showed that while WD significantly increased fat percentage and elevated plasma cholesterol, there was no change in blood glucose level or body weight, indicating an early stage of MetS. Nevertheless, this was associated with neuroinflammation and impaired cognitive functions. However, there was no significant impact on cardiovascular function and mitochondrial bioenergetics. Importantly, the mild MetS induced by WD triggered basal motor, cognitive deterioration and exacerbated the long-term neuropathology of TBI. Taken together, our work highlights the magnitude of the contribution of lifestyle factors including the type of diet, even in the absence of overt metabolic consequences, on the neurobehavioral prognosis following TBI. (c) 2024 The Author(s). Published by Elsevier Ltd on behalf of Tsinghua University Press. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
C1 [Nwaiwu, Judith; Ibeh, Stanley; Reslan, Mohammad Amine; Mekhjian, Sarin; Haidar, Muhammad Ali; Kobeissy, Firas] Amer Univ Beirut, Fac Med, Dept Biochem & Mol Genet, Beirut 11072020, Lebanon.
   [Nwaiwu, Judith; Sanni, Akeem; Goli, Mona; Mechref, Yehia] Texas Tech Univ, Dept Chem & Biochem, Lubbock, TX 79409 USA.
   [Ibeh, Stanley] Dalhousie Univ, Fac Med, Dept Biochem & Mol Biol, Halifax, NS B3H 4R2, Canada.
   [Bakkar, Nour-Mounira Z.] Amer Univ Beirut, Fac Med, Dept Pharmacol & Toxicol, Beirut 11072020, Lebanon.
   [Nasrallah, Leila] Univ Laval, Fac Med, Dept Psychiat & Neurosci, Quebec City, PQ G1V 0A6, Canada.
   [Eid, Ali H.] Qatar Univ, Coll Med, Dept Basic Med Sci, QU Hlth, Doha 2713, Qatar.
   [Obeid, Omar] Amer Univ Beirut, Fac Agr & Food Sci, Dept Nutr & Dietet, Beirut 11072020, Lebanon.
   [El Khoury, Riyad] Amer Univ Beirut, Dept Pathol & Lab Med, Med Ctr, Beirut 11072020, Lebanon.
   [El-Yazbi, Ahmed F.] Alexandria Univ, Fac Pharm, Dept Pharmacol & Toxicol, Alexandria 21521, Egypt.
   [El-Yazbi, Ahmed F.] Alamein Int Univ, Fac Pharm Res & Innovat Hub, Alamein 51718, Egypt.
   [Kobeissy, Firas] Morehouse Sch Med, Ctr Neurotrauma Multi & Biomarkers CNMB, Dept Neurobiol, 720 Westview Dr SW, Atlanta, GA 30310 USA.
C3 American University of Beirut; Texas Tech University System; Texas Tech
   University; Dalhousie University; American University of Beirut; Laval
   University; Qatar University; American University of Beirut; American
   University of Beirut; Egyptian Knowledge Bank (EKB); Alexandria
   University; Alamein International University (AIU); Morehouse School of
   Medicine
RP Kobeissy, F (corresponding author), Amer Univ Beirut, Fac Med, Dept Biochem & Mol Genet, Beirut 11072020, Lebanon.; Mechref, Y (corresponding author), Texas Tech Univ, Dept Chem & Biochem, Lubbock, TX 79409 USA.; El-Yazbi, AF (corresponding author), Alexandria Univ, Fac Pharm, Dept Pharmacol & Toxicol, Alexandria 21521, Egypt.; El-Yazbi, AF (corresponding author), Alamein Int Univ, Fac Pharm Res & Innovat Hub, Alamein 51718, Egypt.; Kobeissy, F (corresponding author), Morehouse Sch Med, Ctr Neurotrauma Multi & Biomarkers CNMB, Dept Neurobiol, 720 Westview Dr SW, Atlanta, GA 30310 USA.
EM yehia.mechref@ttu.edu; ayazbi@aiu.edu.eg; firasko@gmail.com
RI Nwaiwu, Judith/MSW-6483-2025; El-Yazbi, Ahmed/AAT-6837-2021; Obeid,
   Omar/AAK-1669-2020; Bakkar, Nour/MGA-8112-2025; Kobeissy,
   Firas/E-7042-2017; Eid, Ali/ABD-6291-2021
OI Eid, Ali/0000-0003-3004-5675; Bakkar, Nour-Mounira/0000-0002-6403-9348;
   Sanni, Akeem/0000-0002-1250-7293; Nwaiwu, Judith/0000-0002-7885-1345
FU Science, Technology and Innovation Funding Authority, Egypt [45912]
FX This work was funded by grant number 45912 from the Science, Technology
   and Innovation Funding Authority, Egypt to AFE.
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NR 76
TC 0
Z9 0
U1 0
U2 2
PU TSINGHUA UNIV PRESS
PI BEIJING
PA B605D, XUE YAN BUILDING, BEIJING, 100084, PEOPLES R CHINA
SN 2324-2426
J9 J NEURORESTORATOLOGY
JI J. NEURORESSTORATOLOGY
PD SEP
PY 2024
VL 12
IS 3
AR 100140
DI 10.1016/j.jnrt.2024.100140
EA AUG 2024
PG 14
WC Clinical Neurology
WE Emerging Sources Citation Index (ESCI)
SC Neurosciences & Neurology
GA C8B0N
UT WOS:001291556200001
OA gold
DA 2025-06-11
ER

PT J
AU Barbhuiya, PA
   Sen, S
   Pathak, MP
AF Barbhuiya, Pervej Alom
   Sen, Saikat
   Pathak, Manash Pratim
TI Ameliorative role of bioactive phytoconstituents targeting obesity
   associated NAFLD by modulation of inflammation and lipogenesis pathways:
   a comprehensive review
SO PHYTOCHEMISTRY REVIEWS
LA English
DT Review
DE NAFLD; Obesity; Metabolic syndrome; Bioactive phytoconstituents;
   Inflammation; Lipogenesis
ID FATTY LIVER-DISEASE; DE-NOVO LIPOGENESIS; HEPATIC STEATOSIS;
   ADIPOSE-TISSUE; NONALCOHOLIC STEATOHEPATITIS; INSULIN-RESISTANCE;
   VITAMIN-E; OBETICHOLIC ACID; OXIDATIVE STRESS; LIPID-METABOLISM
AB By 2025, the projected global obesity rates for both men and women are 18% and 21%, respectively. Obesity raises the risk of several comorbidities like cardiovascular disease, gastrointestinal disorders, type 2 diabetes, respiratory problems, and most importantly non-alcoholic fatty liver disease (NAFLD). NAFLD is commonly considered to be both a consequence and a contributor to metabolic dysfunctions such as obesity, given the liver's pivotal role in metabolism. NAFLD is a range of disease phenotypes that initiate hepatocyte inflammation and lipid accumulation owing to de novo lipogenesis (DNL). NAFLD has the potential to advance to non-alcoholic steatohepatitis, marked by hepatic fibrosis and the subsequent emergence of NAFLD-associated cirrhosis and hepatocellular carcinoma. Several notable biomarkers, including C-reactive protein, tumour necrosis factor-alpha, interleukin-6, leptin, fatty acid synthase and sterol regulatory element binding protein-1c have been found to have a direct correlation with inflammation and DNL. Several research studies have provided evidence regarding the effectiveness and safety of plant derived bioactive compounds plants for managing obesity associated NAFLD. Several bioactive phytoconstituents like antcin A, ginsenoside, naringenin, apigenin, silibinin, kaempferol have been identified as potential agents for improving obesity associated NAFLD by targeting the inflammatory and DNL pathways. This review explores the connection between inflammation and DNL in the development of obesity-associated NAFLD by discussing a few biomarkers related to both the hallmarks and some novel avenues for addressing the treatment of NAFLD in individuals with obesity. Besides, this review provides an overview of the efficacy of different bioactive phytoconstituents in combating obesity associated NAFLD by targeting the inflammatory and DNL pathways.
C1 [Barbhuiya, Pervej Alom; Sen, Saikat; Pathak, Manash Pratim] Assam Down Town Univ, Fac Pharmaceut Sci, Gauhati 781026, Assam, India.
   [Barbhuiya, Pervej Alom; Sen, Saikat; Pathak, Manash Pratim] Assam Down Town Univ, Fac Pharmaceut Sci, Ctr Res Ethnomed, Gauhati 781026, Assam, India.
C3 Assam Down Town University; Assam Down Town University
RP Pathak, MP (corresponding author), Assam Down Town Univ, Fac Pharmaceut Sci, Gauhati 781026, Assam, India.
EM manashpharma@rediffmail.com
RI Sen, Saikat/E-8091-2011; Pathak, Manash Pratim/I-3539-2019
OI Sen, Saikat/0000-0002-5279-1532; Barbhuiya, Pervej
   Alom/0000-0001-7483-0857; Pathak, Manash Pratim/0000-0002-9182-7948
FU University for awarding Junior Research Fellow under the "AdtU Scheme
   for award of Fellowship (JRF/SRF) for PhD Scholars"
FX One of the authors, Mr. Pervej Alom Barbhuiya, is thankful to Assam down
   town University for awarding Junior Research Fellow under the "AdtU
   Scheme for award of Fellowship (JRF/SRF) for PhD Scholars" and providing
   necessary support for carrying out this work.
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NR 210
TC 6
Z9 6
U1 4
U2 19
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1568-7767
EI 1572-980X
J9 PHYTOCHEM REV
JI Phytochem. Rev.
PD AUG
PY 2024
VL 23
IS 4
BP 969
EP 996
DI 10.1007/s11101-023-09912-w
EA DEC 2023
PG 28
WC Plant Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences
GA L1N5J
UT WOS:001131854000001
DA 2025-06-11
ER

PT J
AU Chen, DY
   Meng, ZY
   Zhao, TT
   Yu, XQ
   He, H
   Hua, F
   Dong, WL
AF Chen, Danyan
   Meng, Ziyan
   Zhao, Tingting
   Yu, Xueqian
   He, Hong
   Hua, Fang
   Dong, Weili
TI Association between sleep-disordered breathing and periodontal diseases:
   A systematic review protocol
SO FRONTIERS IN MEDICINE
LA English
DT Review
DE sleep-disordered breathing; obstructive sleep apnea; periodontal
   diseases; systematic review; protocol
ID APNEA; RISK; PREVALENCE
AB Background: Sleep-disordered breathing (SDB) is a chronic sleep-related breathing disorder, considered associated with increased risk of cardiovascular disorders, metabolic disorders, cognitive dysfunction and behavior changes. Periodontal diseases are chronic infectious diseases that are also believed to be associated with cardiovascular diseases, metabolic syndrome and cognitive dysfunction. Several studies have indicated that SDB may be associated with periodontal diseases through certain mechanisms such as inflammation response, oxidative stress and oral dryness. The aim of this systematic review is to explore the association between SDB and periodontal diseases in an integrated approach. Materials and Methods: This systematic review will include cohort studies, cross-sectional studies and case-control studies that are identified by electronic and manual searches. Electronic searches will be conducted in the following databases: PubMed, Embase, Scopus and Web of Science. Our search will cover articles published from inception of databases to March 2022 without restrictions in language and settings. Pre-determined eligibility criteria include: participants (participants without a history of respiratory diseases, history of periodontal treatment within the past 6 months and history of medication that is known to influence SDB or periodontal diseases); exposure (participants who have been diagnosed with SDB or at high-risk for SDB); comparison (participants without SDB); and outcome (periodontal parameters, such as probing depth, clinical attachment level, bleeding on probing, radiographic bone loss). Two authors will perform study screening and data extraction independently and in duplicate. All discrepancies will be solved by discussion. The methodological quality of included studies will be assessed using the Newcastle-Ottawa Scale. Discussion: This systematic review will summarize the existing evidence on the association between SDB and periodontal diseases, a topic of controversy and clinical significance. Its findings can provide evidence for the development of relevant prevention and treatment strategies. The results will be disseminated through peer-reviewed journals.
C1 [Chen, Danyan; Dong, Weili] Wuhan Univ, Sch & Hosp Stomatol, Hubei MOST KLOS, Wuhan, Hubei, Peoples R China.
   [Chen, Danyan; Dong, Weili] Wuhan Univ, Sch & Hosp Stomatol, Dept Periodontol, Wuhan, Peoples R China.
   [Meng, Ziyan] Nanjing Med Univ, Dept Periodontol, Affiliated Stomatol Hosp, Nanjing, Peoples R China.
   [Meng, Ziyan] Jiangsu Prov Key Lab Oral Dis, Nanjing, Peoples R China.
   [Meng, Ziyan] Jiangsu Prov Engn Res Ctr Stomatol Translat Med, Nanjing, Peoples R China.
   [Zhao, Tingting; He, Hong] Wuhan Univ, Sch & Hosp Stomatol, Dept Orthodont, Wuhan, Peoples R China.
   [Zhao, Tingting; He, Hong; Hua, Fang] Wuhan Univ, Sch & Hosp Stomatol, Ctr Dentofacial Dev & Sleep Med, Wuhan, Peoples R China.
   [Yu, Xueqian] Wuhan Univ, Sch & Hosp Stomatol, Lib, Wuhan, Peoples R China.
   [Hua, Fang] Wuhan Univ, Sch & Hosp Stomatol, Ctr Evidence Based Stomatol, Wuhan, Peoples R China.
   [Hua, Fang] Univ Manchester, Fac Biol, Sch Med Sci, Div Dent, Manchester, Lancashire, England.
C3 Wuhan University; Wuhan University; Nanjing Medical University; Wuhan
   University; Wuhan University; Wuhan University; Wuhan University;
   University of Manchester
RP Dong, WL (corresponding author), Wuhan Univ, Sch & Hosp Stomatol, Hubei MOST KLOS, Wuhan, Hubei, Peoples R China.; Dong, WL (corresponding author), Wuhan Univ, Sch & Hosp Stomatol, Dept Periodontol, Wuhan, Peoples R China.; Hua, F (corresponding author), Wuhan Univ, Sch & Hosp Stomatol, Ctr Dentofacial Dev & Sleep Med, Wuhan, Peoples R China.; Hua, F (corresponding author), Wuhan Univ, Sch & Hosp Stomatol, Ctr Evidence Based Stomatol, Wuhan, Peoples R China.; Hua, F (corresponding author), Univ Manchester, Fac Biol, Sch Med Sci, Div Dent, Manchester, Lancashire, England.
EM huafang@whu.edu.cn; zdwlss272@whu.edu.cn
RI Hua, Fang/G-6344-2013
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NR 47
TC 0
Z9 0
U1 1
U2 16
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 2296-858X
J9 FRONT MED-LAUSANNE
JI Front. Med.
PD AUG 8
PY 2022
VL 9
AR 960245
DI 10.3389/fmed.2022.960245
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 3Y1OJ
UT WOS:000843498500001
PM 36004374
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Shree, B
   Kumar, S
   Priyanka
   Sharma, S
   Katoch, V
AF Shree, Bharti
   Kumar, Satish
   Priyanka
   Sharma, Shweta
   Katoch, Viveka
TI Functional significance of underutilized high value cruciferous
   vegetables- an exotic gleam in the gloomy guise of their functional
   importance
SO SOUTH AFRICAN JOURNAL OF BOTANY
LA English
DT Review
DE Underutilized crucifers vegetables; Bioactive compounds; Molecular
   techniques; Processing
ID RAPE BRASSICA-NAPUS; SEED OIL CONTENT; RED CABBAGE EXTRACT; L. VAR.
   BOTRYTIS; OXIDATIVE STRESS; BRUSSELS-SPROUTS; OILSEED RAPE;
   AGROBACTERIUM-TUMEFACIENS; ANTIOXIDANT ACTIVITY; BIOACTIVE COMPOUNDS
AB Crucifers have long been documented for their potential therapeutic food properties and are also referred to as the super-foods. They include the crops like kale, collards, kohlrabi, and brussels sprouts. These constitute the major source of secondary metabolites viz. flavonoids, anthocyanins, carotenoids, polyphenols, vitamins, minerals, coumarins, antioxidant enzymes, terpenes. Long-term and regular consumption of these vegetables helps to fight against obesity, cancer, atherosclerosis, inflammation, metabolic syndrome, and reduces the risk of several diseases. In the raw form, the availability and bioactivity of these phytonutrients have been reported to the highest levels. The scientific confirmation of these functional benefits though needs systematic clinical documentation and most of the research efforts in the last decade are focused in this direction. Further, processing affects the availability and activity of the bioactive compounds adversely thus, appropriate methods should be adopted for processing and cooking these vegetables. In order to promote their development and sustainable conservation, methods like micropropagation, cryopreservation, in vitro conservation, tissue culture, somatic hybridization, DNA banks, mycorrhization and genetic engineering shall be adopted. Several biotic and abiotic stresses have been reported to increase the availability of the secondary metabolites significantly which can be standardized to boost their functionality. Molecular breeding approaches such as marker-assisted selection, marker-assisted back cross, generation sequencing and gene editing also hold tremendous potential for improving the yield and quality of these super-foods. This review has been conceptualized to provide in-depth knowledge about the health benefits, effects of processing, strategies to improve and conserve the underutilized cruciferous vegetables, and the developments made in the area of production, processing, and value addition of the crucifers in the last decade.(c) 2022 SAAB. Published by Elsevier B.V. All rights reserved.
C1 [Shree, Bharti] CSK HPKV, Dept Agr Biotechnol, Palampur 176062, Himachal Prades, India.
   [Kumar, Satish] Dr Yashwant Singh Parmar Univ Hort & Forestry, Coll Hort & Forestry, Solan 173230, HP, India.
   [Priyanka] Punjab Agr Univ Ludhiana, Dept Vegetable Sci, Ludhiana 141004, Punjab, India.
   [Sharma, Shweta] Shoolini Univ Biotechnol & Management Sci, MS Swaminathan Sch Agr, Solan 173229, HP, India.
   [Katoch, Viveka] CSK HPKV, Dept Vegetable Sci & Floriculture, Palampur 176062, Himachal Prades, India.
C3 Ch. Sarwan Kumar Himachal Pradesh Krishi Vishvavidyalaya; Dr. Yashwant
   Singh Parmar University of Horticulture & Forestry; Punjab Agricultural
   University; Shoolini University; Ch. Sarwan Kumar Himachal Pradesh
   Krishi Vishvavidyalaya
RP Sharma, S (corresponding author), Shoolini Univ Biotechnol & Management Sci, MS Swaminathan Sch Agr, Solan 173229, HP, India.
EM shwetasharma15123@gmail.com
RI Sharma, Shweta/GQA-8060-2022; Shree, Bharti/ISU-9698-2023; Kumar,
   Satish/GOV-5666-2022
OI Sharma, Shweta/0000-0002-9586-4332; Kumar, Satish/0000-0003-2264-9006
FU Shoolini University (Solan), UHF Nauni (Solan), CSK HPKV, Palampur; PAU,
   Ludhiana
FX Authors are greatly thankful to Shoolini University (Solan), UHF Nauni
   (Solan), CSK HPKV, Palampur, and PAU, Ludhiana for the in-infrastructure
   and support required for making data available.
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NR 226
TC 6
Z9 6
U1 0
U2 11
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0254-6299
EI 1727-9321
J9 S AFR J BOT
JI S. Afr. J. Bot.
PD MAR
PY 2022
VL 145
SI SI
BP 420
EP 437
DI 10.1016/j.sajb.2022.02.028
PG 18
WC Plant Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences
GA 1N0YX
UT WOS:000800390600001
OA hybrid
DA 2025-06-11
ER

PT J
AU Jin, T
   Park, EY
   Kim, B
   Oh, JK
AF Jin, Taiyue
   Park, Eun Young
   Kim, Byungmi
   Oh, Jin-Kyoung
TI Association between Blood Mercury Concentration and Prevalence of
   Borderline Hypercholesterolemia among Adolescents: The Korea National
   Health and Nutrition Examination Survey (KNHANES) 2010-2013 and 2016
SO TOXICS
LA English
DT Article
DE mercury (Hg); dyslipidemia; hypercholesterolemia; hyper-LDL
   cholesterolemia; adolescents
ID PROLIFERATOR-ACTIVATED RECEPTOR; PHYSICAL-ACTIVITY QUESTIONNAIRE;
   CARDIOVASCULAR RISK-FACTORS; CORONARY-HEART-DISEASE; METABOLIC SYNDROME;
   OXIDATIVE STRESS; LIPID-METABOLISM; ALPHA EXPRESSION; EXPOSURE; CHILDREN
AB There is limited evidence on the association between blood mercury (Hg) concentration and the risk of borderline dyslipidemia in adolescents. Here, we investigated the association between blood Hg concentration and the prevalence of borderline dyslipidemia among Korean adolescents. A total of 1559 participants (806 boys and 753 girls) aged 10-18 years who cross-sectionally enrolled in the Korea National Health and Nutrition Examination Survey (KNHANES) 2010-2013 and 2016 were included in this study. Hg concentrations (mu g/L) in whole blood samples were measured. The geometric mean (GM) of the blood Hg concentration was 1.88 mu g/L. It showed a 63% higher prevalence of borderline hypercholesterolemia (total cholesterol (TC) 170-199 mg/dL) per unit of natural log-transformed blood Hg concentration in boys (95% CI = 1.10-2.41), but not in girls. When a categorical model was applied, the positive association with the prevalence of borderline hypercholesterolemia was also persistant in boys (OR (95% CI) for 2nd and 3rd tertiles (Hg concentration 1.532-11.761 mu g/L) vs. 1st tertile (Hg concentration 0.192-1.531 mu g/L): 1.92 (1.19-3.10)), but not in girls. This finding suggests that blood Hg concentration might result in a higher prevalence of borderline hypercholesterolemia among adolescents and more stringent public health actions should be taken for the reduction of Hg exposure to prevent dyslipidemia from early-childhood, despite the need of further study to evaluate a causal relationship between blood Hg concentration and the risk of dyslipidemia.</p>
C1 [Jin, Taiyue; Park, Eun Young; Kim, Byungmi; Oh, Jin-Kyoung] Natl Canc Ctr, Canc Prevent Div, Natl Canc Control Inst, Goyang Si 10408, Gyeonggi Do, South Korea.
   [Oh, Jin-Kyoung] Natl Canc Ctr, Dept Canc Control & Populat Hlth, Grad Sch Canc Sci & Policy, Goyang Si 10408, Gyeonggi Do, South Korea.
C3 National Cancer Center - Korea (NCC); National Cancer Center - Korea
   (NCC)
RP Park, EY (corresponding author), Natl Canc Ctr, Canc Prevent Div, Natl Canc Control Inst, Goyang Si 10408, Gyeonggi Do, South Korea.
EM taewol@ncc.re.kr; goajoa@ncc.re.kr; kbm5369@ncc.re.kr; jkoh@ncc.re.kr
RI Kim, Byung-Hak/AAY-9891-2020; Choi, Youn/AAS-3301-2021; Park, Young
   Sik/MBG-1896-2025
OI Jin, Taiyue/0000-0003-0144-3850; Kim, Byungmi/0000-0001-8621-9190
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NR 58
TC 3
Z9 3
U1 0
U2 2
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2305-6304
J9 TOXICS
JI Toxics
PD OCT
PY 2021
VL 9
IS 10
AR 242
DI 10.3390/toxics9100242
PG 14
WC Environmental Sciences; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Toxicology
GA WO8CY
UT WOS:000712676700001
PM 34678938
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Iqbal, J
   Al Qarni, A
   Bakillah, A
AF Iqbal, Jahangir
   Al Qarni, Ali
   Bakillah, Ahmed
TI Diet-induced differential effects on plasma lipids secretion by the
   inositol-requiring transmembrane kinase/endoribonuclease 1α
SO FRONTIERS IN BIOSCIENCE-LANDMARK
LA English
DT Article
DE Lipoproteins; Lipids; Atherosclerosis; Obesity; Diabetes; Endoplasmic
   reticulum; Unfolded protein response; Microsomal triglyceride transfer
   protein; Inositol-requiring transmembrane kinase/endoribonuclease 1
   alpha; Inositol-requiring transmembrane kinase/endoribonuclease 1 beta
ID TRIGLYCERIDE TRANSFER PROTEIN; ENDOPLASMIC-RETICULUM STRESS; HEPATIC
   LIPOGENESIS; SENSOR IRE1; EXPRESSION; HYPERLIPIDEMIA; SUPPRESSION;
   IRE1-ALPHA; STEATOSIS; INCREASE
AB Intestinal and hepatic lipid metabolism plays an essential role in regulating plasma lipid levels. These lipids are mobilized on apolipoprotein B (apoB)-containing lipoproteins and their plasma homeostasis is maintained by balancing production and catabolism. Microsomal triglyceride transfer protein (MTP) which is expressed mainly in the intestine and liver plays an essential role in regulating the assembly and secretion of apoB-lipoproteins. Any imbalance in the production or clearance of lipoproteins leads to hyperlipidemia which is a major risk factor for atherosclerosis, obesity, diabetes, and metabolic syndrome. Here, we identify a new role of inositol-requiring transmembrane kinase/endoribonuclease 1 alpha (IRE1 alpha) in the regulation of plasma lipids. We generated intestine specific IRE1 alpha knockout mice to study whether intestinal IRE1 alpha regulates plasma lipids by modulating intestinal lipid absorption. Intestine specific deletion of Ire1a gene in mice fed chow diet, significantly reduced plasma cholesterol and triglycerides by 29% and 43% in Ire1a(-/-) mice (P < 0.01 P < 0.001, respectively). These changes were not associated with any alteration of MTP activity nor its mRNA expression. On the other hand, Western diet increased plasma triglyceride by 37% (P < 0.01) without affecting total plasma cholesterol in Ire1a(-/- )mice. Interestingly, this effect was associated with a significant increase in the intestinal MTP activity and its mRNA expression (25%, P < 0.01 and 70%, P < 0.05, respectively). Collectively, our findings reveal key role of intestinal IRE1 alpha in the regulation of plasma lipids that may provide a therapeutic target for disorders of lipid metabolism.
C1 [Iqbal, Jahangir; Al Qarni, Ali; Bakillah, Ahmed] King Saud Bin Abdulaziz Univ Hlth Sci KSAU HS, King Abdulaziz Hosp KAH, Minist Natl Guard Hlth Affairs MNG HA, King Abdullah Int Med Res Ctr KAIMRC Eastern Reg, Al Hasa 31982, Saudi Arabia.
   [Iqbal, Jahangir; Bakillah, Ahmed] SUNY Downstate Med Ctr, Dept Cell Biol, Brooklyn, NY 11203 USA.
C3 King Saud Bin Abdulaziz University for Health Sciences; State University
   of New York (SUNY) System; SUNY Downstate Health Sciences University
RP Iqbal, J (corresponding author), King Saud Bin Abdulaziz Univ Hlth Sci KSAU HS, King Abdulaziz Hosp KAH, Minist Natl Guard Hlth Affairs MNG HA, King Abdullah Int Med Res Ctr KAIMRC Eastern Reg, Al Hasa 31982, Saudi Arabia.; Iqbal, J (corresponding author), SUNY Downstate Med Ctr, Dept Cell Biol, Brooklyn, NY 11203 USA.
EM iqbalja@ngha.med.sa
RI Bakillah, Ahmed/HLG-6158-2023; Iqbal, Jahangir/B-3903-2014
OI Al Qarni, Ali/0000-0002-2413-6637
FU American Heart Association [12GRNT9690010]; KAIMRC [RA16-024-A,
   RA17-013-A]; International Collaboration Initiative grant from the
   Ministry of Education [RA20-005-A, 230]; American Heart Association
   (AHA) [12GRNT9690010] Funding Source: American Heart Association (AHA)
FX This work was supported in part by an American Heart Association
   Grant-in-Aid (12GRNT9690010), KAIMRC grants (RA16-024-A and RA17-013-A)
   and the International Collaboration Initiative grant from the Ministry
   of Education (RA20-005-A, Project #230) to J.I.
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NR 34
TC 1
Z9 1
U1 0
U2 7
PU IMR PRESS
PI ROBINSON
PA 112 ROBINSON RD, ROBINSON, SINGAPORE
SN 2768-6701
EI 2768-6698
J9 FRONT BIOSCI-LANDMRK
JI Front. Biosci.
PD APR 1
PY 2021
VL 26
IS 5
BP 11
EP 21
DI 10.52586/4920
PG 11
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA RZ4RV
UT WOS:000648585400002
PM 34027646
OA gold
DA 2025-06-11
ER

PT J
AU Wu, Y
   Liu, W
   Yang, T
   Li, M
   Qin, LL
   Wu, LL
   Liu, TH
AF Wu, You
   Liu, Wei
   Yang, Tao
   Li, Mei
   Qin, Lingling
   Wu, Lili
   Liu, Tonghua
TI Oral administration of mangiferin ameliorates diabetes in animal models:
   a meta-analysis and systematic review
SO NUTRITION RESEARCH
LA English
DT Review
DE Mangiferin; Meta-analysis; Diabetes mellitus; Insulin resistance; Animal
   models
ID HIGH-FAT DIET; INSULIN-RESISTANCE; METABOLIC SYNDROME; OXIDATIVE STRESS;
   NEPHROPATHY PROGRESSION; ANEMARRHENAE-RHIZOMA; SALACIA-CHINENSIS;
   NATURAL-PRODUCTS; SKELETAL-MUSCLE; DOWN-REGULATION
AB Although mangiferin has a number of documented beneficial effects, there are no systematic reviews or meta-analyses of its effects in diabetic animal models. To investigate the effects of oral administration of mangiferin on blood glucose levels, body weight, and total cholesterol and triglycerides levels in diabetic animal models, a meta-analysis was conducted and the underlying mechanisms were reviewed. Studies from 6 databases (PubMed, Web of Science, Embase, Cochrane Library, and CNKI (China National Knowledge Infrastructure), and Wanfang Med) were searched from inception to April 2020. After article screening, a total of 19 articles were included in this meta-analysis. The meta-analysis was performed using RevMan 5.3 and STATA 14.0 software. The overall pooled estimate of standardized mean difference (SMD) of mangiferin's effect on blood glucose was & minus;1.27 (95% confidence interval [CI]: & minus;1.71, & minus;0.82, P < .00001). Body weight increased in lean diabetic animals with an SMD of 1.41 (95% CI: 0.57, 2.25; P = .001), while it decreased in obese diabetic animals with an SMD of & minus;0.92 (95% CI: & minus;1.69, & minus;0.14; P = .02). Mangiferin intake reduced serum total cholesterol and triglycerides levels with SMDs of & minus;1.02 (95% CI: & minus;1.43, & minus;0.61; P < .001) and & minus;1.24 (95% CI: & minus;1.70, & minus;0.79; P < .001), respectively. The meta-analysis suggests that oral intake of mangiferin has a significant antidiabetic effect in animal models, and the systematic review suggested that this function might be attributed to its anti-inflammatory and antioxidative properties, as well as to its function of improving glycolipid metabolism and enhancing insulin signaling.
   (c) 2020 Elsevier Inc. All rights reserved.
C1 [Wu, You; Liu, Wei; Yang, Tao; Li, Mei; Qin, Lingling; Wu, Lili; Liu, Tonghua] Beijing Univ Chinese Med, Minist Educ, Key Lab Hlth Cultivat, Beijing 100029, Peoples R China.
   [Wu, You; Liu, Wei] Beijing Univ Chinese Med, Dongfang Hosp, Beijing 100078, Peoples R China.
C3 Beijing University of Chinese Medicine; Ministry of Education - China;
   Beijing University of Chinese Medicine
RP Wu, LL; Liu, TH (corresponding author), Beijing Univ Chinese Med, Minist Educ, Key Lab Hlth Cultivat, Beijing 100029, Peoples R China.
EM qingniao_566@163.com; thliu@vip.163.com
RI liu, th/KBQ-0635-2024; Wu, You/AAG-2495-2021; Qin,
   Lingling/ABC-6600-2020; Li, Mei/ISU-9988-2023
OI Wu, You/0000-0002-0179-8865; liu, tong-hua/0000-0001-7015-5348
FU International Cooperation Base for the Prevention and Treatment of
   Chronic Diseases by Traditional Chinese Medicine [GZYYGJ2019034];
   International Cooperation Research Center for the Prevention and
   Treatment of Diabetes by Traditional Chinese Medicine [2015B01022]
FX The authors declare that the research was conducted in the absence of
   any commercial or financial relationships that could be construed as a
   potential conflict of interest. We are grateful for the support from the
   International Cooperation Base for the Prevention and Treatment of
   Chronic Diseases by Traditional Chinese Medicine [grant number:
   GZYYGJ2019034]; International Cooperation Research Center for the
   Prevention and Treatment of Diabetes by Traditional Chinese Medicine
   [grant number: 2015B01022] We are also grateful to Prof. Yan-ling Zhao
   with her instructions on this research.
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NR 94
TC 11
Z9 14
U1 0
U2 42
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0271-5317
EI 1879-0739
J9 NUTR RES
JI Nutr. Res.
PD MAR
PY 2021
VL 87
BP 57
EP 69
DI 10.1016/j.nutres.2020.12.017
EA FEB 2021
PG 13
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA RG4KG
UT WOS:000635508800007
PM 33601215
DA 2025-06-11
ER

PT J
AU Shkolnikova, MA
   Jdanov, DA
   Ildarova, RA
   Shcherbakova, NV
   Polyakova, EB
   Mikhaylov, EN
   Shalnova, SA
   Shkolnikov, VM
AF Shkolnikova, Maria A.
   Jdanov, Dmitri A.
   Ildarova, Rukizhat A.
   Shcherbakova, Natalia V.
   Polyakova, Ekaterina B.
   Mikhaylov, Evgeny N.
   Shalnova, Svetlana A.
   Shkolnikov, Vladimir M.
TI Atrial fibrillation among Russian men and women aged 55 years and older:
   prevalence, mortality, and associations with biomarkers in a
   population-based study
SO JOURNAL OF GERIATRIC CARDIOLOGY
LA English
DT Article
DE Aging; Atrial fibrillation; Gender differences; Holter monitoring;
   Mortality; Prevalence
ID C-REACTIVE PROTEIN; FOLLOW-UP; RISK-FACTORS; ATHEROSCLEROSIS RISK;
   METABOLIC SYNDROME; SEX-DIFFERENCES; HEART-FAILURE; LIFETIME RISK;
   EPIDEMIOLOGY; DISEASE
AB Objective To examine the prevalence of atrial fibrillation (AF), its impacts on cardiovascular disease (CVD) and all-cause mortality, and the associations between AF and inflammatory and serum biomarkers in a population-based sample of Muscovites. Methods The study is a secondary analysis of data from the Stress, Aging and Health in Russia (SAHR) survey that includes information on 1800 individuals with an average age of 68.5 years at baseline, and on their subsequent mortality during 7.4 years on average. AF is detected by 12-lead electrocardiogram (ECG) and 24-hour Holter monitoring. The statistical analysis includes proportional hazard and logistic regression models. Results Of the 1732 participants with relevant Holter data, AF was detected in 100 (74 by ECG and Holter, 26 by Holter only). The prevalence of AF was 5.8% for men and 7.4% for women. The fully adjusted model showed strongly elevated hazard of CVD and all-cause mortality in men and women with long non-self-limiting AF (LAF). LAF was found to be negatively associated with elevated total and low-density lipoprotein cholesterol and to be positively associated with elevated markers of inflammation in women. Conclusions The study assessed for the first time the prevalence and the risks of death related to AF among older Russians. LAF was shown to be a strong and independent predictor of CVD and all-cause mortality. AF is unlikely to contribute to the large excess male mortality in Russia. The finding that one-quarter of AF cases were detected only by Holter monitoring demonstrates the usefulness of diagnostics with prolonged ECG registration.
C1 [Shkolnikova, Maria A.; Ildarova, Rukizhat A.; Shcherbakova, Natalia V.; Polyakova, Ekaterina B.] Pirogov Russian Natl Res Med Univ, Veltischev Res & Clin Inst Pediat, Moscow, Russia.
   [Jdanov, Dmitri A.; Shkolnikov, Vladimir M.] Max Planck Inst Demog Res, Lab Demog Data, Rostock, Germany.
   [Jdanov, Dmitri A.; Shkolnikov, Vladimir M.] Res Univ Higher Sch Econ, Int Lab Populat & Hlth, Moscow, Russia.
   [Mikhaylov, Evgeny N.] Almazov Natl Med Res Ctr, Arrhythmia Dept, St Petersburg, Russia.
   [Mikhaylov, Evgeny N.] Almazov Natl Med Res Ctr, Neuromodulat Lab, St Petersburg, Russia.
   [Shalnova, Svetlana A.] Natl Res Ctr Prevent Med, Moscow, Russia.
C3 Pirogov Russian National Research Medical University; Max Planck
   Society; HSE University (National Research University Higher School of
   Economics); Almazov National Medical Research Centre; Almazov National
   Medical Research Centre; National Medical Research Center for Therapy &
   Preventive Medicine
RP Shcherbakova, NV (corresponding author), Pirogov Russian Natl Res Med Univ, Veltischev Res & Clin Inst Pediat, Moscow, Russia.
EM shcherbakova.n@pedklin.ru
RI Shcherbakova, Natalia/U-1290-2019; Jdanov, Dmitri/F-9425-2014;
   Mikhaylov, Evgeny/K-7922-2012
OI Jdanov, Dmitri/0000-0003-4633-2011; Mikhaylov,
   Evgeny/0000-0002-6553-9141; Shcherbakova, Natalia/0000-0002-6672-4242
FU U.S. National Institutes of Health (NIH) [P01AG031719]; Russian program
   of the state support of leading universities of the Russian Federation
   "5-100"; Russian Federation President Grant Council's grant
   [MD-2314.2020.7]; NIH [R01AG026786]
FX This work was supported by the U.S. National Institutes of Health (NIH)
   grant P01AG031719. D.A.J. and V.M.S. were partly supported by the
   Russian program of the state support of leading universities of the
   Russian Federation "5-100". E.N.M. was supported by the Russian
   Federation President Grant Council's grant #MD-2314.2020.7. We used data
   from SAHR, an earlier study that had been supported by the NIH grant
   R01AG026786. The funders had no role in the study design; in the
   collection, analysis, or interpretation of the data; or in the
   preparation, review, or approval of the manuscript.
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NR 60
TC 11
Z9 11
U1 0
U2 3
PU SCIENCE PRESS
PI BEIJING
PA 16 DONGHUANGCHENGGEN NORTH ST, BEIJING 100717, PEOPLES R CHINA
SN 1671-5411
J9 J GERIATR CARDIOL
JI J. Geriatr. Cardiol.
PY 2020
VL 17
IS 2
BP 74
EP 84
DI 10.11909/j.issn.1671-5411.2020.02.002
PG 11
WC Cardiac & Cardiovascular Systems; Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Cardiovascular System & Cardiology; Geriatrics & Gerontology
GA KU2GL
UT WOS:000519526600002
PM 32165880
DA 2025-06-11
ER

PT J
AU Roshanravan, N
   Alizadeh, M
   Jafarabadi, MA
   Alamdari, NM
   Mohammadi, H
   Farrin, N
   Tarighat-Esfanjani, A
AF Roshanravan, Neda
   Alizadeh, Mohammad
   Jafarabadi, Mohammad Asghari
   Alamdari, Naimeh Mesri
   Mohammadi, Hamed
   Farrin, Nazila
   Tarighat-Esfanjani, Ali
TI Effect of prenatal zinc supplementation on adipose tissue-derived
   hormones and neonatal weight, height and head circumference in women
   with impaired glucose tolerance test: randomized clinical controlled
   trial
SO INTERNATIONAL JOURNAL OF DIABETES IN DEVELOPING COUNTRIES
LA English
DT Article
DE Zinc; Leptin; Visfatin; Zinc--alpha(2)-glycoprotein; Pregnancy
ID GESTATIONAL DIABETES-MELLITUS; NECROSIS-FACTOR-ALPHA;
   INSULIN-RESISTANCE; LEPTIN LEVELS; TNF-ALPHA; SERUM
   ZINC-ALPHA-2-GLYCOPROTEIN; VISFATIN CONCENTRATIONS; PLASMA ADIPONECTIN;
   METABOLIC SYNDROME; OXIDATIVE STRESS
AB Background It is well known that normal pregnancy exposes mothers to a diabetogenic state. The important role of adipose tissue in the regulation of insulin resistance has been repeatedly proven. This organ carries out the regulation of insulin resistance by producing adipocytokines involved in the pathogenesis of gestational diabetes mellitus (GDM). The present study aims to evaluate the effects of zinc supplementation on serum leptin, visfatin, tumor necrosis factor-alpha (TNF-alpha), adiponectin and zinc-alpha 2-glycoprotein (ZAG) levels in pregnant women with impaired glucose tolerance test (IGTT) results. Methods In this randomized, placebo-controlled, double-blind clinical trial, 46 pregnant women with impaired glucose tolerance test results were randomly distributed into zinc (n = 23) and placebo (n = 23) groups and received 30 mg zinc supplement per day in the form of zinc gluconate and placebo, respectively, for 8 consecutive weeks. The study was conducted in the Shabestar district of northwestern Iran. Results Supplementation after adjusting for confounding variables resulted in a significant reduction in plasma leptin (p = 0.035) and TNF-alpha (p = 0.027) levels in the zinc group compared with the placebo group. Serum visfatin levels were significantly increased, and serum ZAG levels were significantly decreased in both groups. However, the changes in adiponectin concentration were not significant in either group after intervention nor were the anthropometric parameters in fetuses whose mothers received the zinc supplement. Conclusions It seems that zinc supplementation may be considered as a complementary supplement together with the medical management of patients with IGT or GDM. However, further studies are needed before definite conclusions can be drawn.
C1 [Roshanravan, Neda] Tabriz Univ Med Sci, Cardiovasc Res Ctr, Tabriz, Iran.
   [Roshanravan, Neda; Farrin, Nazila] Tabriz Univ Med Sci, Nutr Res Ctr, Tabriz, Iran.
   [Alizadeh, Mohammad] Tabriz Univ Med Sci, Nutr Res Ctr, Tabriz, Iran.
   [Jafarabadi, Mohammad Asghari] Tabriz Univ Med Sci, Sch Hlth, Rd Traff Injury Prevent Res Ctr, Tabriz, Iran.
   [Jafarabadi, Mohammad Asghari] Tabriz Univ Med Sci, Fac Hlth, Dept Stat & Epidemiol, Tabriz, Iran.
   [Alamdari, Naimeh Mesri] Iran Univ Med Sci, Sch Hlth, Students Res Comm, Tehran, Iran.
   [Mohammadi, Hamed] Isfahan Univ Med Sci, Sch Nutr & Food Sci, Dept Clin Nutr, Esfahan, Iran.
   [Mohammadi, Hamed] Isfahan Univ Med Sci, Student Res Comm, Esfahan, Iran.
   [Tarighat-Esfanjani, Ali] Tabriz Univ Med Sci, Sch Nutr, Nutr Res Ctr, Attar Nishabouri St,POB 14711, Tabriz 5166614711, Iran.
C3 Tabriz University of Medical Science; Tabriz University of Medical
   Science; Tabriz University of Medical Science; Tabriz University of
   Medical Science; Tabriz University of Medical Science; Iran University
   of Medical Sciences; Isfahan University of Medical Sciences; Isfahan
   University of Medical Sciences; Tabriz University of Medical Science
RP Tarighat-Esfanjani, A (corresponding author), Tabriz Univ Med Sci, Sch Nutr, Nutr Res Ctr, Attar Nishabouri St,POB 14711, Tabriz 5166614711, Iran.
EM Tarighata@tbzmed.ac.ir
RI Tarighat-Esfanjani, Ali/R-8625-2019; Alizadeh, Mohammad/M-4703-2017;
   Farrin, Nazila/M-6545-2017; Mohammadi, Hamed/Q-3166-2019; Asghari
   Jafarabadi, Mohammmad/A-7478-2017
OI Mesri Alamdari, Naimeh/0000-0003-2563-8193; Asghari Jafarabadi,
   Mohammmad/0000-0003-3284-9749
FU Tabriz University of Medical Sciences [91227]
FX This work was supported by the Tabriz University of Medical Sciences
   [grant number: 91227].
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NR 63
TC 1
Z9 1
U1 0
U2 9
PU SPRINGER INDIA
PI NEW DELHI
PA 7TH FLOOR, VIJAYA BUILDING, 17, BARAKHAMBA ROAD, NEW DELHI, 110 001,
   INDIA
SN 0973-3930
EI 1998-3832
J9 INT J DIABETES DEV C
JI Int. Diabetes Dev. Ctries.
PD JUL
PY 2019
VL 39
IS 3
BP 471
EP 477
DI 10.1007/s13410-018-0707-1
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA IO3AZ
UT WOS:000479254200010
DA 2025-06-11
ER

PT J
AU Tucci, S
AF Tucci, Sara
TI Very long-chain acyl-CoA dehydrogenase (VLCAD-) deficiency-studies on
   treatment effects and long-term outcomes in mouse models
SO JOURNAL OF INHERITED METABOLIC DISEASE
LA English
DT Article
ID FATTY-ACID OXIDATION; BETA-OXIDATION; ADIPOSE-TISSUE; LIPID-METABOLISM;
   SEX-DIFFERENCES; MICE; CARDIOMYOPATHY; TRIGLYCERIDES; DISORDERS;
   ACCUMULATION
AB Very-long-chain-acyl-CoA-dehydrogenase deficiency is the most common disorder of mitochondrial long-chain fatty acid (LCFA) oxidation, with an incidence of 1:50,000-1:100,000 in newborns. Catabolic situations contribute to the aggravation of symptoms and induce severe metabolic derangement. Treatment for VLCAD-deficiency includes avoidance of fasting and a long-chain fat-restricted and fat-modified diet in which LCFAs are fully or partially replaced by medium-chain triglycerides (MCT). The aim of this work was to investigate the outcome and the effects of long-term treatment in a mouse model of VLCAD-deficiency. The application of a single MCT bolus in a mouse model of VLCAD-deficiency (VLCAD(-/-) mice) immediately prior to exercise protected the muscles from the accumulation of acylcarnitines providing the required energy and it did not affect hepatic lipid metabolism. However, when MCT was applied over the course of a year as a regular part of the diet, female VLCAD(-/-) mice developed a severe clinical phenotype comparable to the human metabolic syndrome. Indeed, they were characterized by massive visceral fat infiltration, hepatosteatosis, disturbed fatty acid composition, hyperlipidemia, and systemic oxidative stress. In contrast, male VLCAD(-/-) mice seemed to be protected and displayed only signs of insulin resistance. Besides the sex-specific response to MCT supplementation with regard to the lipid metabolism, all VLCAD(-/-) mice developed progressive cardiac dysfunction over time which worsened when they were treated with regular MCT resulting in severe dilated cardiomyopathy. While long term use of MCT oil in mice has adverse effects, no such effects have been demonstrated in humans, likely reflecting the differences in long chain fatty acid oxidation between the two species.
C1 [Tucci, Sara] Univ Freiburg, Ctr Pediat & Adolescent Med, Med Ctr, Dept Gen Pediat, Mathildenstr 1, D-79106 Freiburg, Germany.
C3 University of Freiburg
RP Tucci, S (corresponding author), Univ Freiburg, Ctr Pediat & Adolescent Med, Med Ctr, Dept Gen Pediat, Mathildenstr 1, D-79106 Freiburg, Germany.
EM sara.tucci@uniklinik-freiburg.de
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NR 60
TC 21
Z9 24
U1 0
U2 11
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0141-8955
EI 1573-2665
J9 J INHERIT METAB DIS
JI J. Inherit. Metab. Dis.
PD MAY
PY 2017
VL 40
IS 3
BP 317
EP 323
DI 10.1007/s10545-017-0016-8
PG 7
WC Endocrinology & Metabolism; Genetics & Heredity; Medicine, Research &
   Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Genetics & Heredity; Research & Experimental
   Medicine
GA ES6LS
UT WOS:000399660000004
PM 28247148
DA 2025-06-11
ER

PT J
AU Vinué, A
   Andrés-Blasco, I
   Herrero-Cervera, A
   Piqueras, L
   Andrés, V
   Burks, DJ
   Sanz, MJ
   González-Navarro, H
AF Vinue, Angela
   Andres-Blasco, Irene
   Herrero-Cervera, Andrea
   Piqueras, Laura
   Andres, Vicente
   Burks, Deborah J.
   Jesus Sanz, Maria
   Gonzalez-Navarro, Herminia
TI Ink4/Arf locus restores glucose tolerance and insulin
   sensitivity by reducing hepatic steatosis and inflammation in mice with
   impaired IRS2-dependent signalling
SO BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
LA English
DT Article
DE CDKN2A/2B; Diabetes; Insulin resistance; Inflammation; Steatosis;
   Macrophage
ID GENOME-WIDE ASSOCIATION; CORONARY-ARTERY-DISEASE; METABOLIC SYNDROME;
   FATTY LIVER; RESISTANCE; IRS-2; ATHEROSCLEROSIS; SUSCEPTIBILITY;
   MACROPHAGE; RECEPTOR
AB Single nucleotide polymorphisms near the Ink4/Arf locus have been associated with type-2 diabetes mellitus. Previous studies indicate a protective role of the locus in the carbohydrate metabolism derangement associated with ageing in wild-type mice. The present study demonstrates that the increased Ink4/Arf locus expression in 1-year-old mice, partially-deficient for the insulin receptor substrate (IRS)2 (Irs2 +/-SuperInk4/Arf mice) ameliorates hepatic steatosis, inflammation and insulin resistance. Irs2 +/-SuperInk4/Arf mice displayed improved glucose tolerance and insulin sensitivity compared with Irs2 +/- mice which were glucose intolerant and insulin resistant compared with age-matched wild-type mice. These changes in Irs2 +/- mice were accompanied by enhanced hepatic steatosis, proinflammatory macrophage phenotype, increased Ly6C(hi)-monocyte percentage, T-lymphocyte activation and MCP1 and TNF-alpha cytokine levels. In Irs2 +/- SuperInk4/Arf mice, steatosis and inflammatory parameters were markedly reduced and similar to those of wild-type counterparts. In vivo insulin signalling also revealed reduced activation of the IRS/ART-dependent signalling in Irs2 mice. This was restored upon increased locus expression in Irs2 +/- SuperInk4/Arf mice which display similar activation levels as those for wild-type mice. In vivo treatment of Irs2 +/- SuperInk4/Arf mice with TNF-alpha diminished insulin canonical IRS/AKT-signalling and enhanced the stress SAPMNK-phosphoSer307IRS1-pathway suggesting that cytokine levels might potentially affect glucose homeostasis through changes in these insulin-signalling pathways. Altogether, these results indicate that enhanced Ink4/Arf locus expression restores glucose homeostasis and that this is associated with diminished hepatic steatosis and inflammation in mice with insulin resistance. Therefore, pharmacological interventions targeted to modulate the Ink4/Arf locus expression could be a tentative therapeutic approach to alleviate the inflammation associated with insulin resistance. Published by Elsevier B.V.
C1 [Vinue, Angela; Andres-Blasco, Irene; Herrero-Cervera, Andrea; Piqueras, Laura; Jesus Sanz, Maria; Gonzalez-Navarro, Herminia] Hlth Res Inst INCLIVA, Valencia 46010, Spain.
   [Andres, Vicente] CNIC, Dept Atherothrombosis Imaging & Epidemiol, Madrid 28029, Spain.
   [Burks, Deborah J.] CIPF, Valencia 46012, Spain.
   [Burks, Deborah J.; Gonzalez-Navarro, Herminia] CIBERDEM, Madrid, Spain.
   [Jesus Sanz, Maria] Univ Valencia, Dept Farmacol, Valencia 46010, Spain.
C3 Centro Nacional de Investigaciones Cardiovasculares (CNIC); Prince
   Felipe Research Center; CIBER - Centro de Investigacion Biomedica en
   Red; CIBERDEM; University of Valencia
RP González-Navarro, H (corresponding author), Hlth Res Inst INCLIVA, Avd Menendez Pelayo 4, Valencia 46010, Spain.
EM gonzaleh@uv.es
RI Sanz, Maria/A-6099-2016; PIQUERAS, LAURA/LXW-1265-2024; Andres,
   Vicente/I-6440-2014
OI , Andrea/0000-0001-6490-6504; Andres, Vicente/0000-0002-0125-7209;
   PIQUERAS, LAURA/0000-0001-8010-5168; Sanz, Maria
   Jesus/0000-0002-8885-294X; Gonzalez-Navarro,
   Herminia/0000-0001-6883-3808
FU Carlos III Health Institute [FIS: PI-CP10/00555, PI13/00834,
   RD12/0042/0028]; Spanish Ministry of the Economy and Competitiveness;
   Generalitat Valenciana [SAF2011-23777, GVACOMP2014-16]; European
   Regional Development Fund (FEDER); 'Miguel Servet' programme
   [CP10/00555]; Proyecto Paula; CIBERDEM, a Carlos III Health Institute
   initiative; Spanish Ministry of Economy and Competitiveness; Pro-CNIC
   Foundation
FX This study was supported by grants from the Carlos III Health Institute
   (FIS: PI-CP10/00555 and PI13/00834 to H.G.-N.; and RD12/0042/0028 to
   V.A.), from the Spanish Ministry of the Economy and Competitiveness and
   from the Generalitat Valenciana (SAF2011-23777 and GVACOMP2014-16,
   respectively, to MJS) and from the European Regional Development Fund
   (FEDER). H.G.-N. is an investigator from the 'Miguel Servet' programme
   (CP10/00555). I.A-B. and A.V. received salary support from Proyecto
   Paula. This work was also supported by the CIBERDEM, a Carlos III Health
   Institute initiative. The CNIC is supported by the Spanish Ministry of
   Economy and Competitiveness and the Pro-CNIC Foundation.
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NR 49
TC 9
Z9 10
U1 0
U2 9
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0925-4439
EI 1879-260X
J9 BBA-MOL BASIS DIS
JI Biochim. Biophys. Acta-Mol. Basis Dis.
PD SEP
PY 2015
VL 1852
IS 9
BP 1729
EP 1742
DI 10.1016/j.bbadis.2015.05.013
PG 14
WC Biochemistry & Molecular Biology; Biophysics; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Cell Biology
GA CP5XQ
UT WOS:000359959100005
PM 26022372
OA Bronze
DA 2025-06-11
ER

PT J
AU Kamali, SH
   Khalaj, AR
   Hasani-Ranjbar, S
   Esfehani, MM
   Kamalinejad, M
   Soheil, O
   Kamali, SA
AF Kamali, Seyed Hamid
   Khalaj, Ali Reza
   Hasani-Ranjbar, Shirin
   Esfehani, Mohammad Mehdi
   Kamalinejad, Mohammad
   Soheil, Omidmalayeri
   Kamali, Seyed Ali
TI Efficacy of 'Itrifal Saghir', a combination of three medicinal plants in
   the treatment of obesity; A randomized controlled trial
SO DARU-JOURNAL OF PHARMACEUTICAL SCIENCES
LA English
DT Article
DE Obesity; Itrifal Saghir; Traditional Iranian medicine; Randomized trial;
   Terminalia chebula; Terminalia bellerica; Emblica officinalis; Triphala
ID AYURVEDIC FORMULATION; METABOLIC SYNDROME; OXIDATIVE STRESS; TRIPHALA;
   ANTIOXIDANT; TOXICITY; PROPERTY; SAFETY
AB Background: Herbal combination of Itrifal Saghir (triphala) has been widely used in traditional medicine. And brings health benefits such as antioxidant effect and scavenger of hydroxyl radicals and nitric oxide radicals activity and substantiated in traditional medicine a anti-obesity.
   Material and method: In this study we aimed to assess the efficacy of this herbal medicinal on reduction of weight and body mass index (BMI) of simple obese subjects in comparison with placebo. Obese subjects aged between 16 and 60 years were selected for 12-week, double-blind, randomized, placebo-controlled trial using a parallel design. Subjects were randomly assigned to take 5 grams of either the Itrifal Saghir (n = 31) or placebo (n = 31), 2 times daily for 12 weeks. Measures of body weight, BMI, waist circumference (WC), hip circumference (HC), were assessed at baseline and once every four weeks during the 12 week treatment period. The safety was evaluated by means of measuring the liver and kidney function. Homeostasis model of insulin resistance (HOMA-IR) was calculated as [fasting insulin (mu U/mL) x fasting glucose (mmol/L)/22.5].
   Results: Compared to placebo group, in treatment group the mean difference of effective weight loss was 4.82Kg (CI95% 3.52 -6.11, rho < 0.001), the mean of decrease in waist circumference was 4.01 cm (CI 95% 2.13 -5.90, rho < 0.001), and the mean decrease in hip circumference was 3. 21 cm (CI 95% 1.96 - 4.45, rho < 0.001) in treated subjects. No adverse effects or significant changes in liver and kidney function tests were observed in both placebo and treated groups.
   Conclusions: Itrifal Saghir appears to produce a positive effect on weight loss in obese subjects.
C1 [Kamali, Seyed Hamid] Shahed Univ, Fac Med, Dept Iranian Tradit Med, Tehran 1947948613, Iran.
   [Esfehani, Mohammad Mehdi] Univ Tehran Med Sci, Sch Tradit Med, Tehran, Iran.
   [Khalaj, Ali Reza] Shahed Univ, Dept Surg, Mostafa Khomeyni Hosp, Iranian Tradit Med Grp,Clin Salamat 17, Tehran 1947948613, Iran.
   [Hasani-Ranjbar, Shirin] Univ Tehran Med Sci, Endocrinol & Metab Res Inst, Shariati Hosp, Tehran, Iran.
   [Hasani-Ranjbar, Shirin] Univ Tehran Med Sci, Fac Med, Shariati Hosp, Tehran, Iran.
   [Kamalinejad, Mohammad] Shahid Beheshti Univ Med Sci, Sch Pharm, Dept Pharmacognosy, Tehran, Iran.
   [Soheil, Omidmalayeri; Kamali, Seyed Ali] Khatam Hosp, Tehran, Iran.
C3 Shahed University; Tehran University of Medical Sciences; Shahed
   University; Tehran University of Medical Sciences; Tehran University of
   Medical Sciences; Shahid Beheshti University Medical Sciences
RP Khalaj, AR (corresponding author), Shahed Univ, Dept Surg, Mostafa Khomeyni Hosp, Iranian Tradit Med Grp,Clin Salamat 17, Dashtestan 3rd St,Pasdaran Ave, Tehran 1947948613, Iran.
EM arkhalaj@yahoo.com; sh_hasani@tums.ac.ir
RI Mahmoudabadi, Mohammad/H-1472-2017
OI Kamalinejad, Mohammad/0000-0002-5946-4913
FU shahed university
FX This study was conducted as Dr. Seyed hamid kamali postgraduate thesis.
   We thank all the study participants for their participation. The authors
   gratefully acknowledge the help of the following individuals: Mostafa
   Ghorbani and Ramin Heshmat for the randomization procedure; Mania Radfar
   for contributing to protocol of compliance design; Sudabeh Alatab for
   english editing the article. This study was supported by a research
   grant provided by shahed university.
CR [Anonymous], 2001, SPSS WIND REL 11 0 1
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NR 36
TC 40
Z9 41
U1 0
U2 10
PU SPRINGER INTERNATIONAL PUBLISHING AG
PI CHAM
PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND
EI 2008-2231
J9 DARU
JI DARU
PD SEP 10
PY 2012
VL 20
AR 33
DI 10.1186/2008-2231-20-33
PG 8
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 090AD
UT WOS:000314950300001
PM 23351558
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Slivkoff-Clark, KM
   James, AP
   Mamo, JCL
AF Slivkoff-Clark, Karin M.
   James, Anthony P.
   Mamo, John C. L.
TI The chronic effects of fish oil with exercise on postprandial lipaemia
   and chylomicron homeostasis in insulin resistant viscerally obese men
SO NUTRITION & METABOLISM
LA English
DT Article
ID POLYUNSATURATED FATTY-ACIDS; PLASMA TRIGLYCERIDE CONCENTRATIONS;
   LOW-DENSITY-LIPOPROTEIN; SERUM-LIPIDS; AEROBIC EXERCISE; DOCOSAHEXAENOIC
   ACIDS; POSTMENOPAUSAL WOMEN; APOLIPOPROTEIN B-48; REMNANTS INFLUENCES;
   OXIDATIVE STRESS
AB Background: Visceral obesity and insulin resistance are associated with a postprandial accumulation of atherogenic chylomicron remnants that is difficult to modulate with lipid-lowering therapies. Dietary fish oil and exercise are cardioprotective interventions that can significantly modify the metabolism of TAG-rich lipoproteins. In this study, we investigated whether chronic exercise and fish oil act in combination to affect chylomicron metabolism in obese men with moderate insulin resistance.
   Methods: The single blind study tested the effect of fish oil, exercise and the combined treatments on fasting and postprandial chylomicron metabolism. Twenty nine men with metabolic syndrome were randomly assigned to take fish oil or placebo for four weeks, before undertaking an additional 12 week walking program. At baseline and at the end of each treatment, subjects were tested for concentrations of fasting apo B48, plasma lipids and insulin. Postprandial apo B48 and TAG kinetics were also determined following ingestion of a fat enriched meal.
   Results: Combining fish oil and exercise resulted in a significant reduction in the fasting apo B48 concentration, concomitant with attenuation of fasting TAG concentrations and the postprandial TAG(IAUC) response (p < 0.05). Fish oil by itself reduced the postprandial TAG response ( p < 0.05) but not postprandial apo B48 kinetics. Individual treatments of fish oil and exercise did not correspond with improvements in fasting plasma TAG and apo B48.
   Conclusion: Fish oil was shown to independently improve plasma TAG homeostasis but did not resolve hyperchylomicronaemia. Instead, combining fish oil with chronic exercise reduced the plasma concentration of proatherogenic chylomicron remnants; in addition it reduced the fasting and postprandial TAG response in viscerally obese insulin resistant subjects.
C1 [Mamo, John C. L.] Curtin Univ, Sch Publ Hlth, Curtin Hlth Innovat Res Inst, Perth, WA 6102, Australia.
   Curtin Univ, Ctr Metab Fitness, Australian Technol Network, Perth, WA 6102, Australia.
C3 Curtin University; Curtin University
RP Mamo, JCL (corresponding author), Curtin Univ, Sch Publ Hlth, Curtin Hlth Innovat Res Inst, Bentley Campus,Kent St, Perth, WA 6102, Australia.
EM J.Mamo@curtin.edu.au
RI Clark, Katya/Q-2539-2018; James, Anthony/A-2241-2008
OI Mamo, John/0000-0002-5741-7849; James, Anthony/0000-0002-0873-3714;
   Slivkoff-Clark, Katya/0000-0002-0812-7079
FU Australian Postgraduate Award; Australian Federation of University Women
FX The authors would like to thank Dr Richard Woodman and Professor
   Satvinder Dhaliwal for their guidance on statistical analyses. This
   research was supported by an Australian Postgraduate Award and an
   Australian Federation of University Women Mary and Elsie Stevens
   Bursary.
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NR 61
TC 26
Z9 28
U1 0
U2 5
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1743-7075
J9 NUTR METAB
JI Nutr. Metab.
PD FEB 7
PY 2012
VL 9
AR 9
DI 10.1186/1743-7075-9-9
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 909RU
UT WOS:000301582900001
PM 22314022
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Kelly, KR
   Haus, JM
   Solomon, TPJ
   Patrick-Melin, AJ
   Cook, M
   Rocco, M
   Barkoukis, H
   Kirwan, JP
AF Kelly, Karen R.
   Haus, Jacob M.
   Solomon, Thomas P. J.
   Patrick-Melin, Aimee J.
   Cook, Marc
   Rocco, Michael
   Barkoukis, Hope
   Kirwan, John P.
TI A Low-Glycemic Index Diet and Exercise Intervention Reduces TNFα in
   Isolated Mononuclear Cells of Older, Obese Adults
SO JOURNAL OF NUTRITION
LA English
DT Article
ID TUMOR-NECROSIS-FACTOR; DEPENDENT INSULINOTROPIC POLYPEPTIDE;
   ADIPOSE-TISSUE MACROPHAGES; MIDDLE-AGED WOMEN; INFLAMMATORY MARKERS;
   CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; PHYSICAL-ACTIVITY; OXIDATIVE
   STRESS; HEART-DISEASE
AB Low-glycemic index diets and exercise independently improve glucose tolerance and reduce diabetes risk. However, the combined effect of a low-glycemic index diet and exercise on inflammation and glucose metabolism is not known. Therefore, we randomized 28 insulin-resistant adults (age: 66 +/- 1 y; BMI: 34.2 +/- 0.7 kg.m(-2)) to a 12-wk, low (LGI = 40) or high- (HGI = 80) glycemic index diet plus aerobic exercise (5 d.wk(-1), 60 min.d(-1), 80-85% heart rate(max)) intervention. All food and fluids were provided during the study. Inflammation was assessed from cytokine (TNF alpha and IL-6) secretion using peripheral blood mononuclear cells (MNC) stimulated overnight with LPS. Glycemic response was determined following ingestion of a 75-g glucose solution. Fasting blood samples were collected for additional cytokine [TNF alpha, IL-6, and monocyte chemoattractant protein 1 (MCP-1)] analysis. Both interventions decreased BMI (P < 0.001), fasting plasma glucose (P=0.01), and insulin (P=0.02). The glycemic response was reduced only in the LGI group (P=0.04). Plasma and MNC-derived TNF alpha secretion were reduced in the LGI group (P=0.02) but increased in the HGI group (P=0.02). Secretion of IL-6 from MNC and plasma IL-6 and MCP-1 concentrations were reduced in the LGI group. The change in MNC-derived TNF alpha (r=0.43; P=0.04) and plasma MCP-1 (r=0.44; P=0.04) correlated with decreases in the glycemic response. These data highlight the importance of diet composition in the treatment and prevention of inflammation and hyperglycemia. A low-glycemic index diet has antiinflammatory and antidiabetogenic effects when combined with exercise in older, obese prediabetics. J. Nutr. 141: 1089-1094, 2011.
C1 [Kelly, Karen R.; Haus, Jacob M.; Solomon, Thomas P. J.; Patrick-Melin, Aimee J.; Cook, Marc; Kirwan, John P.] Cleveland Clin, Dept Pathobiol, Lerner Res Inst, Cleveland, OH 44195 USA.
   [Kirwan, John P.] Cleveland Clin, Dept Gastroenterol Hepatol, Cleveland, OH 44195 USA.
   [Rocco, Michael] Cleveland Clin, Dept Prevent Cardiol, Cleveland, OH 44195 USA.
   [Kelly, Karen R.; Barkoukis, Hope; Kirwan, John P.] Case Western Reserve Univ, Dept Nutr, Sch Med, Cleveland, OH 44106 USA.
   [Haus, Jacob M.; Kirwan, John P.] Case Western Reserve Univ, Dept Physiol, Sch Med, Cleveland, OH 44106 USA.
C3 Cleveland Clinic Foundation; Cleveland Clinic Foundation; Cleveland
   Clinic Foundation; University System of Ohio; Case Western Reserve
   University; University System of Ohio; Case Western Reserve University
RP Kirwan, JP (corresponding author), Cleveland Clin, Dept Pathobiol, Lerner Res Inst, Cleveland, OH 44195 USA.
EM kirwanj@ccf.org
RI Kirwan, John/G-6942-2012; Solomon, Thomas/I-4476-2019
OI Haus, Jacob/0000-0002-8048-2470; Solomon, Thomas/0000-0002-0579-284X
FU NIH [RO1 AG12834, T32 DK007319, T32 HL007887]; NIH, National Center for
   Research Resources, Cleveland, Ohio [CTSA 1UL1RR024989]
FX Supported by NIH grant RO1 AG12834 (J.P.K.) and in part by the NIH,
   National Center for Research Resources, CTSA 1UL1RR024989, Cleveland,
   Ohio. K.R.K. was supported by NIH grant T32 DK007319 and J.M.H, was
   supported by NIH grant T32 HL007887.
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NR 49
TC 61
Z9 69
U1 0
U2 17
PU AMER SOC NUTRITION-ASN
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-3166
J9 J NUTR
JI J. Nutr.
PD JUN
PY 2011
VL 141
IS 6
BP 1089
EP 1094
DI 10.3945/jn.111.139964
PG 6
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 768GK
UT WOS:000290921700011
PM 21525252
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Shi, YY
   Chen, JB
   Qu, D
   Sun, Q
   Yu, Y
   Zhang, H
   Liu, ZB
   Sha, JY
   Sun, YS
AF Shi, Yingying
   Chen, Jianbo
   Qu, Di
   Sun, Qiang
   Yu, Yang
   Zhang, Hao
   Liu, Zhengbo
   Sha, Jiyue
   Sun, Yinshi
TI Ginsenoside Rg5 Activates the LKB1/AMPK/mTOR Signaling
   Pathway and Modifies the Gut Microbiota to Alleviate Nonalcoholic Fatty
   Liver Disease Induced by a High-Fat Diet
SO NUTRIENTS
LA English
DT Article
DE ginsenoside Rg(5); nonalcoholic fatty liver disease; fecal microbiota
   transplantation; LKB1/AMPK/mTOR signaling pathway
ID IMPACT
AB The primary objective of this investigation was to elucidate the manner in which ginsenoside Rg(5) (Rg(5)) ameliorates nonalcoholic fatty liver disease (NAFLD) via the modulation of the gut microbiota milieu. We administered either a standard diet (ND) or a high-fat diet (HFD), coupled with 12-week treatment employing two distinct doses of Rg(5) (50 and 100 mg/kg/d), to male C57BL/6J mice. In comparison to the HFD cohort, the Rg(5)-treated group demonstrated significant enhancements in biochemical parameters, exemplified by a substantial decrease in lipid concentrations, as well as the reduced expression of markers indicative of oxidative stress and liver injury. This signifies a mitigation of hepatic dysfunction induced by an HFD. Simultaneously, Rg(5 )demonstrates the capacity to activate the LKB1/AMPK/mTOR signaling pathway, instigating energy metabolism and consequently hindering the progression of NAFLD. Furthermore, we underscored the role of Rg(5) in the treatment of NAFLD within the gut-microbiota-liver axis. Analysis via 16S rRNA sequencing unveiled that Rg(5) intervention induced alterations in gut microbiota composition, fostering an increase in beneficial bacteria, such as Bacteroides and Akkermansia, while concurrently reducing the relative abundance of detrimental bacteria, exemplified by Olsenella. Furthermore, employing fecal microbiota transplantation (FMT) experiments, we observed analogous outcomes in mice subjected to fecal bacterial transplants, providing additional verification of the capacity of Rg(5) to mitigate NAFLD in mice by actively participating in the restoration of gut microbiota via FMT. Drawing from these data, the regulation of the gut microbiota is recognized as an innovative strategy for treating or preventing NAFLD and metabolic syndrome. Consequently, these research findings suggest that Rg5 holds promise as a potential therapeutic agent for NAFLD management.
C1 [Shi, Yingying; Sun, Qiang; Zhang, Hao; Sun, Yinshi] Jilin Agr Univ, Coll Chinese Med Mat, Changchun 130118, Peoples R China.
   [Shi, Yingying; Chen, Jianbo; Qu, Di; Sun, Qiang; Yu, Yang; Zhang, Hao; Liu, Zhengbo; Sha, Jiyue; Sun, Yinshi] Chinese Acad Agr Sci, Inst Special Wild Econ Anim & Plants, Changchun 130112, Peoples R China.
C3 Jilin Agricultural University; Chinese Academy of Agricultural Sciences;
   Institute of Special Animal & Plant Sciences, CAAS
RP Sun, YS (corresponding author), Jilin Agr Univ, Coll Chinese Med Mat, Changchun 130118, Peoples R China.; Sha, JY; Sun, YS (corresponding author), Chinese Acad Agr Sci, Inst Special Wild Econ Anim & Plants, Changchun 130112, Peoples R China.
EM syingying0522@163.com; chenjianbo00882@126.com; qudi@caas.cn;
   sunqiang133543@163.com; m15941105393@163.com; 13103881091@163.com;
   18043213739@163.com; s18946576631@163.com; sunyinshi2015@163.cm
RI Sun, Yinshi/ABA-4746-2021; shi, yingying/E-1112-2015
OI Sun, Yinshi/0000-0002-1889-4984
FU National Key Research and Development Program
FX No Statement Available
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NR 65
TC 7
Z9 8
U1 8
U2 13
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD MAR
PY 2024
VL 16
IS 6
AR 842
DI 10.3390/nu16060842
PG 22
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA MK2V7
UT WOS:001193458900001
PM 38542753
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Ma, YM
   Wei, S
   Dang, LJ
   Gao, L
   Shang, SH
   Hu, NW
   Peng, W
   Zhao, Y
   Yuan, Y
   Zhou, R
   Wang, YY
   Gao, F
   Wang, J
   Qu, QM
AF Ma, Yimeng
   Wei, Shan
   Dang, Liangjun
   Gao, Ling
   Shang, Suhang
   Hu, Ningwei
   Peng, Wei
   Zhao, Yi
   Yuan, Ye
   Zhou, Rong
   Wang, Yanyu
   Gao, Fan
   Wang, Jin
   Qu, Qiumin
TI Association between the triglyceride-glucose index and cognitive
   impairment in China: a community population-based cross-sectional study
SO NUTRITIONAL NEUROSCIENCE
LA English
DT Article
DE cognitive impairment; insulin resistance; triglyceride-glucose index;
   cross-sectional study; association; Alzheimer's disease; dementia; Body
   mass index
ID HOMEOSTASIS MODEL ASSESSMENT; INSULIN-RESISTANCE; ALZHEIMERS-DISEASE;
   INTRANASAL INSULIN; OXIDATIVE STRESS; FASTING GLUCOSE; RISK-FACTORS;
   DYSFUNCTION; METABOLISM; ADIPOSITY
AB Introduction: Insulin resistance (IR) is a feature of metabolic syndrome and plays an important role in cognitive impairment (CI). The triglyceride-glucose (TyG) index is a convenient and cost-effective surrogate for assessing IR. This study aimed to assess the association between the TyG index and CI. Methods: This community population-based cross-sectional study used a cluster-sampling methodology. All participants underwent the education-based Mini-Mental State Examination (MMSE), and those with CI were identified using standard thresholds. The fasting blood triglyceride and glucose levels were measured in the morning, and the TyG index was calculated as ln (1/2 fasting triglyceride level [mg/dL] x fasting blood glucose level [mg/dL]). Multivariable logistic regression and subgroup analysis were used to assess the relationship between the TyG index and CI. Results: This study included 1484 subjects, of which 93 (6.27%) met the CI criteria. Multivariable logistic regression showed that CI incidence increased by 64% per unit increase in the TyG index (odds ratio [OR] = 1.64, 95% confidence interval [CI]: 1.02-2.63, p = 0.042). CI risk was 2.64-fold higher in the highest TyG index quartile compared to the lowest TyG index quartile (OR = 2.64, 95% CI: 1.19-5.85, p = 0.016). Finally, interaction analysis showed that sex, age, hypertension, and diabetes did not significantly affect the association between the TyG index and CI. Conclusion: The present study suggested that an elevated TyG index was associated with a higher CI risk. Subjects with a higher TyG index should manage and treat at an early stage to alleviate the cognitive decline.
C1 [Ma, Yimeng; Wei, Shan; Dang, Liangjun; Gao, Ling; Shang, Suhang; Hu, Ningwei; Peng, Wei; Zhao, Yi; Yuan, Ye; Zhou, Rong; Wang, Yanyu; Wang, Jin; Qu, Qiumin] Xi An Jiao Tong Univ, Dept Neurol, Affiliated Hosp 1, Xian, Peoples R China.
   [Gao, Fan] Xi An Jiao Tong Univ, Clin Res Ctr, Affiliated Hosp 1, Xian, Peoples R China.
   [Qu, Qiumin] Xi An Jiao Tong Univ, Ctr Brain Sci, Affiliated Hosp 1, Xian, Peoples R China.
   [Wang, Jin; Qu, Qiumin] Xi An Jiao Tong Univ, Dept Neurol, Affiliated Hosp 1, 277 West Yanta Rd, Xian 710061, Peoples R China.
C3 Xi'an Jiaotong University; Xi'an Jiaotong University; Xi'an Jiaotong
   University; Xi'an Jiaotong University
RP Wang, J; Qu, QM (corresponding author), Xi An Jiao Tong Univ, Dept Neurol, Affiliated Hosp 1, 277 West Yanta Rd, Xian 710061, Peoples R China.
EM drwangjin@163.com; quqiumin@xjtufh.edu.cn
RI wei, shan/JQX-0669-2023; Wang, Hongfeng/H-1807-2016; 王, 瑾/HGD-5872-2022;
   Li, Xuming/JLM-6754-2023; Ma, Yimeng/K-6967-2019
FU Clinical Research Award of the First Affiliated Hospital of Xi'an
   Jiaotong University [XJTU1AF-CRF-2018-004]; Key Research and Development
   Programs of Shaanxi Province [2018ZDXM-SF-052]
FX This work was supported by the Clinical Research Award of the First
   Affiliated Hospital of Xi'an Jiaotong University [No.
   XJTU1AF-CRF-2018-004] and the Key Research and Development Programs of
   Shaanxi Province [No. 2018ZDXM-SF-052].
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NR 58
TC 11
Z9 11
U1 3
U2 26
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1028-415X
EI 1476-8305
J9 NUTR NEUROSCI
JI Nutr. Neurosci.
PD APR 2
PY 2024
VL 27
IS 4
BP 342
EP 352
DI 10.1080/1028415X.2023.2193765
EA MAR 2023
PG 11
WC Neurosciences; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Nutrition & Dietetics
GA LN3G9
UT WOS:000960219500001
PM 36976719
DA 2025-06-11
ER

PT J
AU Li, A
   Li, YB
   Mei, YY
   Zhao, JX
   Zhou, Q
   Li, K
   Zhao, MD
   Xu, J
   Ge, XY
   Xu, Q
AF Li, Ang
   Li, Yanbing
   Mei, Yayuan
   Zhao, Jiaxin
   Zhou, Quan
   Li, Kai
   Zhao, Meiduo
   Xu, Jing
   Ge, Xiaoyu
   Xu, Qun
TI Associations of metals and metals mixture with lipid profiles: A
   repeated-measures study of older adults in Beijing
SO CHEMOSPHERE
LA English
DT Article
DE Metals mixture; Lipid profiles; Linear mixed-effects model; Bayesian
   kernel machine regression model; Repeated-measures study
ID KERNEL MACHINE REGRESSION; ATHEROGENIC COEFFICIENT; METABOLIC SYNDROME;
   SPRAGUE-DAWLEY; BLOOD-PRESSURE; HEAVY-METALS; SERUM-LIPIDS; MANGANESE;
   TOXICITY; LIVER
AB Metals inevitably and easily enter into human bodies and can induce a series of pathophysiological changes, such as oxidative stress damage and lipid peroxidation, which then may further induce dyslipidemia. However, the effects of metals and metals mixture on the lipid profiles are still unclear, especially in older adults. A three-visits repeated measurement of 201 older adults in Beijing was conducted from November 2016 to January 2018. Linear Mixed Effects models and Bayesian kernel machine regression models were used to estimate associations of eight blood metals and metals mixture with lipid profiles, including total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), Castelli risk indexes I (CRI-1), Castelli risk indexes II (CRI-2), atherogenic coefficient (AC), and non-HDL cholesterol (NHC). Cesium (Cs) was positively associated with TG (beta Cs = 0.14; 95% CI: 0.02, 0.26) whereas copper (Cu) was inversely related to TG (beta Cu =-0.65; 95%CI:-1.14,-0.17) in adjusted models. Manganese (Mn) was mainly related to higher HDL-C (beta Mn = 0.14; 95% CI: 0.07, 0.21) whereas molybdenum showed opposite association. Metals mixture was marginally positive associated with HDL-C, among which Mn played a crucial role. Our findings suggest that the effects of single metal on lipid profiles may be counteracted in mixtures in the context of multiple metal exposures; however, future studies with large sample size are still needed to focus on the detrimental effects of single metals on lipid profiles as well as to identify key components.
C1 [Li, Ang; Li, Yanbing; Mei, Yayuan; Zhao, Jiaxin; Zhou, Quan; Li, Kai; Zhao, Meiduo; Xu, Jing; Ge, Xiaoyu; Xu, Qun] Chinese Acad Med Sci, Sch Basic Med, Dept Epidemiol & Biostat, Inst Basic Med Sci,Peking Union Med Coll, Beijing 100005, Peoples R China.
   [Li, Ang; Li, Yanbing; Mei, Yayuan; Zhao, Jiaxin; Zhou, Quan; Li, Kai; Zhao, Meiduo; Xu, Jing; Ge, Xiaoyu; Xu, Qun] Chinese Acad Med Sci, Peking Union Med Coll, Ctr Environm & Hlth Sci, Beijing 100005, Peoples R China.
C3 Institute of Basic Medical Sciences - CAMS; Chinese Academy of Medical
   Sciences - Peking Union Medical College; Peking Union Medical College;
   Chinese Academy of Medical Sciences - Peking Union Medical College;
   Peking Union Medical College
RP Xu, Q (corresponding author), Chinese Acad Med Sci, Sch Basic Med, Dept Epidemiol & Biostat, Inst Basic Med Sci,Peking Union Med Coll, Beijing 100005, Peoples R China.
EM xuqun@ibms.cams.cn
RI Zhou, Quan/LTG-8185-2024; Xu, Jing/GXN-0678-2022; LI, Kai/JYO-4263-2024
OI Li, Ang/0000-0002-4439-7834
FU Non-profit Central Research Insti- tute Fund of Chinese Academy of
   Medical Sciences [2022-JKCS-11]; CAMS Innovation Fund for Medical
   Sciences [2022-I2M-JB-003]; China Medical Board [15-230]; Fundamental
   Research Funds for the Central Universities [2019-1004-02]; Peking Union
   Medical College Graduate Innovation Fund [MEE -EH -20190802]; China
   Prospective cohort study of Air pollution and health effects in Typical
   areas (C -PAT);  [3332019147]
FX This study was supported by the Non-profit Central Research Insti- tute
   Fund of Chinese Academy of Medical Sciences (2022-JKCS-11) ; CAMS
   Innovation Fund for Medical Sciences (No. 2022-I2M-JB-003) ; China
   Medical Board (Grant No. 15-230) ; China Prospective cohort study of Air
   pollution and health effects in Typical areas (C -PAT) (Grant No. MEE
   -EH -20190802) ; Fundamental Research Funds for the Central Universities
   (Grant No. 3332019147) ; Peking Union Medical College Graduate
   Innovation Fund (No. 2019-1004-02) . These funders were not involved in
   the study design, data collection, analysis, interpretation, and
   writing, and did not impose any restrictions regarding the publi- cation
   of the report.
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NR 86
TC 11
Z9 12
U1 1
U2 15
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0045-6535
EI 1879-1298
J9 CHEMOSPHERE
JI Chemosphere
PD APR
PY 2023
VL 319
AR 137833
DI 10.1016/j.chemosphere.2023.137833
EA FEB 2023
PG 13
WC Environmental Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology
GA C7NX2
UT WOS:000963752400001
PM 36693480
DA 2025-06-11
ER

PT J
AU Smuglov, EP
   Maksimova, EV
   Pashkovsky, DG
AF Smuglov, E. P.
   Maksimova, E., V
   Pashkovsky, D. G.
TI FEATURES OF THE MANAGEMENT OF CORONARY HEART DISEASE IN PATIENTS WITH
   METABOLICALLY ASSOCIATED FATTY LIVER DISEASE
SO NEW ARMENIAN MEDICAL JOURNAL
LA English
DT Article
DE heart disease; non-alcoholic fatty liver disease; thiotriazoline;
   ursodeoxycholic; metabolic defects
ID RISK
AB Among chronic non-communicable diseases, which make a significant contribution to mortality rates in the developed countries of the world, the leading positions are occupied by diseases of the circulatory system. According to statistics, one million people a year die from cardiovascular diseases in Russia. In an extensive nosological group of diseases of the circulatory system, coronary heart disease is the main cause of death and disability in the adult population. The annual mortality from coronary heart disease among the population of Russia is 27 %. To date, the number of patients with coronary heart disease with comorbid pathology, especially with diseases of the hepatobiliary system, metabolic syndrome, is increasing. The prevalence of metabolically associated fatty liver disease is 20 to 30 % in the population and tends to increase. The combined course of metabolically associated fatty liver disease and coronary heart disease occurs in 14-18 % of cases. Objective: to determine the impact of metabolically associated fatty liver disease on the course of coronary heart disease and the possibility of correcting metabolic disorders to prevent the development of cardiovascular complications.Materials and methods. 35 patients with coronary heart disease and metabolically associated fatty liver disease were examined; they were noted to have more severe clinical course of stenocardia and higher risk of cardiovascular complications, then those patients without liver diseases.Results and its discussion. It was estimated, that using thiotriazoline and ursodeoxycholic acid in addition to standard medicamentous therapy improves clinical course of stenocardia as well as overall quality of life due to high antianginal and antioxidant effects. Conclusions. Hepatoprotective therapy increases possibility of correction of metabolic defects, dyslipidemia, decreases the risk of oxidative stress, prevents development of life threatening cardiovascular conditions and can be used to optimize treatment of comorbid patients.
C1 [Smuglov, E. P.; Pashkovsky, D. G.] VI Vernadskiy Crimean Fed Univ, Inst SI Georgievsky Med Acad, Dept Internal Med 2, Simferopol, Russia.
   [Maksimova, E., V] VI Vernadskiy Crimean Fed Univ, Inst SI Georgievsky Med Acad, Dept Therapy, Gastroenterol,Cardiol,Gen Practice Family Med, Simferopol, Russia.
   [Maksimova, E., V] Inst SI Georgievsky Med Acad, FSAEI HE VI Vernadsky CFU, Lenin Blvd 5-7, Simferopol 295051, Russia.
C3 VI Vernadsky Crimean Federal University; VI Vernadsky Crimean Federal
   University
RP Maksimova, EV (corresponding author), Inst SI Georgievsky Med Acad, FSAEI HE VI Vernadsky CFU, Lenin Blvd 5-7, Simferopol 295051, Russia.
EM HelenMaksimovatt@mail.ru
CR Alharthi J, 2022, CURR OPIN GASTROEN, V38, P251, DOI 10.1097/MOG.0000000000000823
   Arslan U, 2020, WORLD J CLIN CASES, V8, P4688, DOI 10.12998/wjcc.v8.i20.4688
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NR 20
TC 1
Z9 1
U1 0
U2 0
PU YEREVAN STATE MEDICAL UNIV
PI YEREVAN
PA 2 KORYUN ST, YEREVAN, 0025, ARMENIA
SN 1829-0825
J9 NEW ARMEN MED J
JI New Armen. Med. J.
PY 2023
VL 17
IS 2
BP 28
EP +
DI 10.56936/18290825-2023.17.2-28
PG 9
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA P7RN7
UT WOS:001052609800004
OA Bronze
DA 2025-06-11
ER

PT J
AU Xiao, ML
   Chen, GD
   Zeng, FF
   Qiu, R
   Shi, WQ
   Lin, JS
   Cao, Y
   Li, HB
   Ling, WH
   Chen, YM
AF Xiao, Mian-li
   Chen, Geng-dong
   Zeng, Fang-fang
   Qiu, Rui
   Shi, Wen-qi
   Lin, Jie-sheng
   Cao, Yi
   Li, Hua-bin
   Ling, Wen-hua
   Chen, Yu-ming
TI Higher serum carotenoids associated with improvement of non-alcoholic
   fatty liver disease in adults: a prospective study
SO EUROPEAN JOURNAL OF NUTRITION
LA English
DT Article
DE Non-alcoholic fatty liver disease; Nutrition; Carotenoids; Prospective
   study; Retinal-binding protein 4; Insulin resistance
ID HOMEOSTASIS MODEL ASSESSMENT; INSULIN-RESISTANCE; LOWER RISK; VITAMIN-E;
   ALANINE AMINOTRANSFERASE; METABOLIC SYNDROME; HEPATIC STEATOSIS;
   JAPANESE SUBJECTS; OXIDATIVE STRESS; LOWER PREVALENCE
AB PurposePrevious studies have suggested that serum carotenoids might be inversely associated with non-alcoholic fatty liver disease (NAFLD), but little data came from longitudinal studies. We prospectively examined the associations between serum-carotenoid levels and NAFLD severity and the intermediary effects of retinol-binding protein 4 (RBP4), HOMA insulin-resistance index (HOMA-IR), body mass index (BMI), and serum triglycerides in middle-aged andelderly Chinese adults.MethodsThis prospective study included 3336 Chinese adults (40-75years). We assessed serum concentrations of carotenoids at baseline and determined serum RBP4, triglycerides, and HOMA-IR levels at year 3. Abdominal ultrasonography was conducted to assess the presence and degree of NAFLD at years 3 and 6.ResultsThe 2687 subjects who completed both NAFLD tests were classified into stable, improved and progressed groups according to changes in the degree of NAFLD between two visits. Analyses of covariance showed that ln-transformed serum concentrations of -carotene, -cryptoxanthin, -carotene, lycopene, lutein/zeaxanthin, and total carotenoids were positively associated with NAFLD improvement (all p-trend<0.05). After multivariable adjustment, mean differences in serum carotenoids were higher by 29.6% (-carotene), 18.2% (-carotene), 15.6% (-cryptoxanthin), 11.5% (lycopene), 8.9% (lutein/zeaxanthin), and 16.6% (total carotenoids) in the improved vs. progressed subjects. Path analyses indicated the carotenoid-NAFLD association was mediated by lowering serum RBP4, triglycerides, HOMA-IR, and BMI, which were positively associated with the prevalence and progression of NAFLD.ConclusionsIn middle-aged and elderly adults, higher serum-carotenoid concentrations were favorably associated with NAFLD improvement, mediated by reducing serum RBP4, triglycerides, HOMA-IR, and BMI.Trial registrationsThis study has been registered at http://www.clinicaltrials.gov as NCT03179657.
C1 [Xiao, Mian-li; Chen, Geng-dong; Zeng, Fang-fang; Qiu, Rui; Lin, Jie-sheng; Cao, Yi; Li, Hua-bin; Ling, Wen-hua; Chen, Yu-ming] Sun Yat Sen Univ, Sch Publ Hlth, Guangdong Prov Key Lab Food Nutr & Hlth, Guangzhou 510080, Guangdong, Peoples R China.
   [Zeng, Fang-fang] Jinan Univ, Sch Med, Dept Epidemiol, Guangzhou, Guangdong, Peoples R China.
   [Shi, Wen-qi] Sun Yat Sen Univ, Affiliated Hosp 3, Guangzhou, Guangdong, Peoples R China.
C3 Sun Yat Sen University; Jinan University; Sun Yat Sen University
RP Chen, YM (corresponding author), Sun Yat Sen Univ, Sch Publ Hlth, Guangdong Prov Key Lab Food Nutr & Hlth, Guangzhou 510080, Guangdong, Peoples R China.
EM chenyum@mail.sysu.edu.cn
RI Xiao, Mianli/KFS-1851-2024; Qi, Ruomei/AAA-2835-2021; Li,
   Hua-Bin/AEX-9846-2022
OI chen, Yu-ming/0000-0003-1658-5528; Chen, Gengdong/0000-0001-7180-8099
FU National Natural Science Foundation of China [81472965, 81372976]; 5010
   Program for Clinical Researches [2007032]; Sun Yat-sen University,
   Guangzhou, P. R. China
FX This study was jointly supported by the National Natural Science
   Foundation of China (No. 81472965 and 81372976), the 5010 Program for
   Clinical Researches (No. 2007032) by the Sun Yat-sen University,
   Guangzhou, P. R. China. The funders had no role in study design, data
   collection and analysis, decision to publish, or preparation of the
   manuscript.
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NR 46
TC 41
Z9 42
U1 0
U2 36
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1436-6207
EI 1436-6215
J9 EUR J NUTR
JI Eur. J. Nutr.
PD MAR
PY 2019
VL 58
IS 2
BP 721
EP 730
DI 10.1007/s00394-018-1678-1
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA HR1XO
UT WOS:000462929800022
PM 29594435
DA 2025-06-11
ER

PT J
AU Kong, Y
   Gao, Y
   Lan, DY
   Zhang, Y
   Zhan, RX
   Liu, MQ
   Zhu, ZA
   Zeng, GH
   Huang, QR
AF Kong, Ying
   Gao, Yan
   Lan, Dongyi
   Zhang, Ying
   Zhan, Rixin
   Liu, Meiqi
   Zhu, Zhouan
   Zeng, Guohua
   Huang, Qiren
TI Trans-repression of NFκB pathway mediated by PPARγ improves vascular
   endothelium insulin resistance
SO JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
LA English
DT Article
DE endothelium; inflammation; insulin resistance; NF kappa B; PPAR gamma
ID ADIPOSE-TISSUE INFLAMMATION; METABOLIC SYNDROME; CELL DYSFUNCTION;
   OBESITY; GLUCOSE; IMPACT; MICE; ACTIVATION; STRESS; TARGET
AB Previous study has shown that thiazolidinediones (TZDs) improved endothelium insulin resistance (IR) induced by high glucose concentration (HG)/hyperglycaemia through a PPAR gamma-dependent-NF kappa B trans-repression mechanism. However, it is unclear, whether changes in PPAR gamma expression affect the endothelium IR and what the underlying mechanism is. In the present study, we aimed to address this issue. HG-treated human umbilical vascular endothelial cells (HUVEC) were transfected by either PPAR gamma-overexpressing (Ad-PPAR gamma) or PPAR gamma-shRNA-containing (Ad-PPAR gamma-shRNA) adenoviral vectors. Likewise, the rats fed by high-fat diet (HFD) were infected by intravenous administration of Ad-PPAR gamma or Ad-PPAR gamma-shRNA. The levels of nitric oxide (NO), endothelin-1 (ET-1) and cytokines (TNF alpha, IL-6, sICAM-1 and sVCAM-1) and the expression levels of PPAR gamma, eNOS, AKT, p-AKT, IKK alpha/beta and p-IKK alpha/beta and I kappa B alpha were examined; and the interaction between PPAR gamma and NF kappa B-P65 as well as vascular function were evaluated. Our present results showed that overexpression of PPAR gamma notably increased the levels of NO, eNOS, p-AKT and I kappa B alpha as well as the interaction of PPAR gamma and NF kappa B-P65, and decreased the levels of ET-1, p-IKK alpha/beta, TNF alpha, IL-6, sICAM-1 and sVCAM-1. In contrast, down-expression of PPAR gamma displayed the opposite effects. The results demonstrate that the overexpression of PPAR gamma improves while the down-expression worsens the endothelium IR via a PPAR gamma-mediated NF kappa B trans-repression dependent manner. The findings suggest PPAR gamma is a potential therapeutic target for diabetic vascular complications.
C1 [Kong, Ying; Gao, Yan; Zhang, Ying; Zhan, Rixin; Liu, Meiqi; Zeng, Guohua; Huang, Qiren] Nanchang Univ, Key Prov Lab Basic Pharmacol, Nanchang, Jiangxi, Peoples R China.
   [Kong, Ying; Gao, Yan; Zhang, Ying; Zhan, Rixin; Liu, Meiqi; Zeng, Guohua; Huang, Qiren] Nanchang Univ, Sch Pharm, Dept Pharmacol, Nanchang, Jiangxi, Peoples R China.
   [Lan, Dongyi; Zhu, Zhouan] Nanchang Univ, Jiangxi Med Coll, Nanchang, Jiangxi, Peoples R China.
C3 Nanchang University; Nanchang University; Nanchang University
RP Huang, QR (corresponding author), Nanchang Univ, Key Prov Lab Basic Pharmacol, Nanchang, Jiangxi, Peoples R China.
EM qrhuang@ncu.edu.cn
FU National Natural Scientific Foundation of China [81070633, 81360060,
   31660323, 30860111]; Jiangxi Provincial Department of Science Technology
   [20123BCB22005]
FX The National Natural Scientific Foundation of China, Grant/Award Number:
   81070633, 81360060, 31660323, 30860111; The Jiangxi Provincial
   Department of Science & Technology, Grant/Award Number: 20123BCB22005
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NR 45
TC 7
Z9 10
U1 0
U2 11
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1582-1838
EI 1582-4934
J9 J CELL MOL MED
JI J. Cell. Mol. Med.
PD JAN
PY 2019
VL 23
IS 1
BP 216
EP 226
DI 10.1111/jcmm.13913
PG 11
WC Cell Biology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Research & Experimental Medicine
GA HF7MI
UT WOS:000454423300019
PM 30398029
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Oliva, MM
   Zuev, V
   Lippa, A
   Carra, MC
   Lisi, F
AF Oliva, M. Montanino
   Zuev, V
   Lippa, A.
   Carra, M. C.
   Lisi, F.
TI Efficacy of the synergic action of myoinositol, tyrosine, selenium and
   chromium in women with PCOS
SO EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
LA English
DT Article
DE Polycystic ovarian syndrome; Myoinositol; Tyrosine; Selenium; Chromium
ID POLYCYSTIC-OVARY-SYNDROME; D-CHIRO-INOSITOL; INSULIN SENSITIVITY;
   METABOLIC SYNDROME; OXIDATIVE STRESS; SUPPLEMENTATION; PICOLINATE;
   DISORDERS; METFORMIN; CONSENSUS
AB OBJECTIVE: The aim of the study is to investigate the efficacy of a treatment with myoinositol plus L-tyrosine, selenium, and chromium in women with polycystic ovarian syndrome (PCOS).
   PATIENTS AND METHODS: One hundred and eighty-six women, with diagnosis of PCOS, were divided in four groups according to their clinical features. Phenotype A: androgen excess + ovulatory dysfunction + polycystic ovarian morphology. Phenotype B: androgen excess + ovulatory dysfunction. Phenotype C: androgen excess + polycystic ovarian morphology. Phenotype D: ovulatory dysfunction + polycystic ovarian morphology. All patients were given daily for six months a compound with 2 g myo-inositol, 0.5 mg L-Tyrosine, 0.2 mg folic acid, 55 mcg selenium, 40 mcg chromium. Hormonal assessment, BMI, Ferriman-Gallway Gallway score, HOMA index, and follicular monitoring were reported before starting the therapy, three months and six months after.
   RESULTS: Phenotype A showed an improvement, consistent with restored ovulation: more regular length of the menstrual cycle, detection of periovulatory follicle at ultrasound. and rising of progesterone in the luteal phase. A total of 45 patients (65.2%) ovulated after six months. In the same period glucose and HOMA index decreased. In the phenotype B, 80% of patients ovulated after six months. An improvement of the clinical and biochemical sign of hyperandrogenism was also reported. In the phenotype C, after BMI had followed the treatment for six months, it decreased in a statistically significant manner. In the phenotype D, 49 out of 82 women (59.7%) restored their regular menstrual period and ovulated.
   CONCLUSIONS: Our study reported how the synergistic action of myoinositol, L-tyrosine, selenium, and chromium could restore normal menstrual cycle, ovulation, and decrease weight in these patients.
C1 [Oliva, M. Montanino; Lippa, A.; Carra, M. C.; Lisi, F.] Ctr Reprod Med Altamed, Rome, Italy.
   [Oliva, M. Montanino; Lippa, A.; Carra, M. C.; Lisi, F.] Ctr Reprod Med Altamed, Milan, Italy.
   [Oliva, M. Montanino] Santo Spirito Hosp, Dept Obstet & Gynecol, Rome, Italy.
   [Zuev, V] Sechenov First Moscow State Med Univ, Dept Obstet & Gynecol, Moscow, Russia.
C3 Sechenov First Moscow State Medical University
RP Oliva, MM (corresponding author), Ctr Reprod Med Altamed, Rome, Italy.; Oliva, MM (corresponding author), Ctr Reprod Med Altamed, Milan, Italy.; Oliva, MM (corresponding author), Santo Spirito Hosp, Dept Obstet & Gynecol, Rome, Italy.
EM m.montaninooliva@gmail.com
RI Oliva, Mario/AAG-9711-2019
OI Montanino Oliva, Mario/0000-0001-8676-1465
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NR 54
TC 8
Z9 9
U1 2
U2 12
PU VERDUCI PUBLISHER
PI ROME
PA VIA GREGORIO VII, ROME, 186-00165, ITALY
SN 1128-3602
J9 EUR REV MED PHARMACO
JI Eur. Rev. Med. Pharmacol. Sci.
PY 2019
VL 23
IS 19
BP 8687
EP 8694
DI 10.26355/eurrev_201910_19186
PG 8
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA JH3RG
UT WOS:000492684500058
PM 31646603
DA 2025-06-11
ER

PT J
AU Daneshi-Maskooni, M
   Keshavarz, SA
   Qorbani, M
   Mansouri, S
   Alavian, SM
   Badri-Fariman, M
   Jazayeri-Tehrani, SA
   Sotoudeh, G
AF Daneshi-Maskooni, Milad
   Keshavarz, Seyed Ali
   Qorbani, Mostafa
   Mansouri, Siavash
   Alavian, Seyed Moayed
   Badri-Fariman, Mahtab
   Jazayeri-Tehrani, Seyed Ali
   Sotoudeh, Gity
TI Green cardamom increases Sirtuin-1 and reduces inflammation in
   overweight or obese patients with non-alcoholic fatty liver disease: a
   double-blind randomized placebo-controlled clinical trial
SO NUTRITION & METABOLISM
LA English
DT Article
DE Non-alcoholic fatty liver disease; Green cardamom; Overweight or
   obesity; Sirtuin-1; Inflammatory factors
ID NF-KAPPA-B; ELETTARIA-CARDAMOMUM; OXIDATIVE STRESS; DIETARY POLYPHENOLS;
   HEPATIC STEATOSIS; DOWN-REGULATION; POTENTIAL ROLE; AGING PROCESS;
   WEIGHT-LOSS; IN-VITRO
AB Background: Non-alcoholic fatty liver disease (NAFLD) is the hepatic component of metabolic syndrome. Despite the beneficial health effects of cardamom on dyslipidemia, hepatomegaly, and fasting hyperglycemia, no previous human study has been conducted on the efficacy of cardamom in NAFLD. The aim of this study was to assess the effects of green cardamom (GC) on serum Sirtuin-1 (Sirt1), inflammatory factors, and liver enzymes in overweight or obese NAFLD patients.
   Methods: The recruitment of subjects was conducted at the polyclinic of the central hospital of National Iranian Oil Company (NIOC), Tehran. Eighty-seven patients who participated were divided randomly into two groups according to the ultrasonography and eligibility criteria as cardamom (n = 43) or placebo (n = 44). The intervention involves taking two 500 mg capsules three times per day with meals for 3 months. General characteristics, dietary intake and physical activity status, weight and height were determined. In addition, serum Sirt1, tumor necrosis factor-alpha (TNF-alpha), high sensitive c-reactive protein (hs-CRP), interleukin-6 (IL-6), alanine transaminase (ALT), and aspartate transaminase (AST) were measured. The degree of fatty liver was determined at beginning and end of the study.
   Results: In comparison with placebo, GC significantly increased Sirt1 and decreased hs-CRP, TNF-alpha, IL-6, ALT, and the degree of fatty liver (P < 0.05). The differences in weight, BMI, and AST were not significant (P> 0.05).
   Conclusion: GC supplementation could improve some biomarkers related to fatty liver including inflammation, ALT, and Sirt1 in overweight/obese NAFLD patients. Further trials on cardamom's potential are suggested.
C1 [Daneshi-Maskooni, Milad; Badri-Fariman, Mahtab; Sotoudeh, Gity] Univ Tehran Med Sci, Dept Community Nutr, Sch Nutr Sci & Dietet, 44 Hojjatdoust Alley,Naderi Ave,Keshavarz Blvd, Tehran 1416643931, Iran.
   [Keshavarz, Seyed Ali; Jazayeri-Tehrani, Seyed Ali] Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Clin Nutr, Tehran, Iran.
   [Qorbani, Mostafa] Alborz Univ Med Sci, Noncommunicable Dis Res Ctr, Karaj, Iran.
   [Mansouri, Siavash] NIOC, Gastroenterohepatol Dept, Cent Hosp, Tehran, Iran.
   [Alavian, Seyed Moayed] Baqiyatallah Univ Med Sci, Baqiyatallah Res Ctr Gastroenterol & Liver Dis BR, Tehran, Iran.
C3 Tehran University of Medical Sciences; Tehran University of Medical
   Sciences; Alborz University of Medical Sciences; National Iranian Oil
   Company (NIOC); Baqiyatallah University of Medical Sciences (BMSU)
RP Sotoudeh, G (corresponding author), Univ Tehran Med Sci, Dept Community Nutr, Sch Nutr Sci & Dietet, 44 Hojjatdoust Alley,Naderi Ave,Keshavarz Blvd, Tehran 1416643931, Iran.; Keshavarz, SA (corresponding author), Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Clin Nutr, Tehran, Iran.
EM s_akeshavarz@yahoo.com
RI Qorbani, Mostafa/M-8171-2017; Ghorashi, Seyed/C-1529-2016; keshavarz,
   Seyed/AAD-3261-2019; Sotoudeh, Gity/E-3973-2018; Daneshi-Maskooni,
   Milad/C-1139-2019
OI Daneshi-Maskooni, Milad/0000-0003-1373-1358; Keshavarz, Seyyed
   Ali/0000-0002-5173-7665
FU Tehran University of Medical Sciences [30123-161-03-94]
FX Funding was supported by the Tehran University of Medical Sciences
   (Code: 30123-161-03-94).
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NR 92
TC 36
Z9 38
U1 1
U2 10
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1743-7075
J9 NUTR METAB
JI Nutr. Metab.
PD SEP 25
PY 2018
VL 15
AR 63
DI 10.1186/s12986-018-0297-4
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA GV1FG
UT WOS:000445814800001
PM 30263038
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Stenlid, R
   Manell, H
   Halldin, M
   Kullberg, J
   Ahlström, H
   Manukyan, L
   Weghuber, D
   Paulmichl, K
   Zsoldos, F
   Bergsten, P
   Forslund, A
AF Stenlid, Rasmus
   Manell, Hannes
   Halldin, Maria
   Kullberg, Joel
   Ahlstrom, Hakan
   Manukyan, Levon
   Weghuber, Daniel
   Paulmichl, Katharina
   Zsoldos, Fanni
   Bergsten, Peter
   Forslund, Anders
TI High DPP-4 Concentrations in Adolescents Are Associated With Low Intact
   GLP-1
SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Article
ID BODY-MASS INDEX; DIPEPTIDYL PEPTIDASE-4 INHIBITORS; OXIDATIVE STRESS
   MARKERS; BETA-CELL FUNCTION; METABOLIC SYNDROME; INCRETIN HORMONES;
   RECEPTOR AGONISTS; IMMUNE-SYSTEM; VISCERAL FAT; OBESITY
AB Context: Dipeptidyl peptidase 4 (DPP-4) metabolizes glucagon-like peptide-1 (GLP-1), and increased DPP4 levels are associated with obesity and visceral adiposity in adults.
   Objective: Investigating DPP-4 levels in adolescents and their association with (1) circulating intact GLP-1 levels and glucose tolerance; (2) body mass index (BMI); and (3) visceral, subcutaneous, and liver fat compartments.
   Design: Cross-sectional study, July 2012 to April 2015.
   Setting: Pediatric obesity clinic, Uppsala University Hospital.
   Patients and Participants: Children and adolescents with obesity (n = 59) and lean controls (n = 21) aged 8 to 18 years.
   Main Outcome Measures: BMI SD score, fasting plasma concentrations of DPP-4, total and intact GLP-1, fasting and oral glucose tolerance test (OGTT) concentrations of glucose, and visceral adipose tissue (VAT) and subcutaneous adipose tissue volumes and liver fat fraction.
   Results: Plasma DPP-4 levels decreased with age in both obese (41 ng/mL per year) and lean subjects (48 ng/mL per year). Plasma DPP-4 levels were higher in males in both the obesity and lean groups. With adjustments for age and sex, plasma DPP-4 level was negatively associated with intact GLP-1 at fasting (beta = -12.3; 95% CI: -22.9, -1.8) and during OGTT (beta = -12.1; 95% CI: -22.5, -1.7). No associations were found between DPP-4 and plasma glucose levels measured at fasting or after a 2-hour OGTT. Plasma DPP-4 level was 19% higher in obese subjects. Among adipose tissue compartments, the strongest association was with VAT (beta = 0.05; 95% CI: -0.02, 0.12).
   Conclusions: In adolescents, high plasma DPP-4 concentrations were associated with low proportions of intactGLP-1, high BMI, young age, and male sex. The observed associations are compatible with increased metabolism of GLP-1 in childhood obesity.
C1 [Stenlid, Rasmus; Manell, Hannes; Manukyan, Levon; Bergsten, Peter] Uppsala Univ, Dept Med Cell Biol, Box 571, SE-75123 Uppsala, Sweden.
   [Stenlid, Rasmus; Manell, Hannes; Halldin, Maria; Bergsten, Peter; Forslund, Anders] Uppsala Univ, Dept Womens & Childrens Hlth, SE-75185 Uppsala, Sweden.
   [Kullberg, Joel; Ahlstrom, Hakan] Uppsala Univ, Sect Radiol, Dept Surg Sci, SE-75185 Uppsala, Sweden.
   [Kullberg, Joel; Ahlstrom, Hakan] Antaros Med, SE-43183 Molndal, Sweden.
   [Weghuber, Daniel; Paulmichl, Katharina; Zsoldos, Fanni] Paracelsus Med Univ, Dept Pediat, A-5020 Salzburg, Austria.
   [Weghuber, Daniel; Paulmichl, Katharina; Zsoldos, Fanni] Paracelsus Med Univ, Obes Res Unit, A-5020 Salzburg, Austria.
C3 Uppsala University; Uppsala University; Uppsala University; Paracelsus
   Private Medical University; Paracelsus Private Medical University
RP Manell, H (corresponding author), Uppsala Univ, Dept Med Cell Biol, Box 571, SE-75123 Uppsala, Sweden.
EM hannes.manell@mcb.uu.se
RI Kullberg, Joel/ABE-3997-2021; Weghuber, Daniel/AAN-1422-2020; Manell,
   Hannes/KVA-8255-2024
OI Manukyan, Levon/0000-0003-3314-5284; Stenlid, Rasmus/0000-0002-1586-9310
FU European Commission's Seventh Framework Programme (FP7/2007-2013)
   project Beta-Judo [279153]; Swedish Diabetes Association [DIA 2016-146];
   Family Ernfors Foundation [160504]; Uppsala-Orebro Regional Research
   Council; Gillberg Foundation (Uppsala, Sweden); Swedish Research Council
   [2016-01040]; EXODIAB; Swedish Society for Diabetology; Selander
   Foundation
FX The study was funded by the European Commission's Seventh Framework
   Programme (FP7/2007-2013) project Beta-Judo (grant no. 279153), Swedish
   Diabetes Association (grant no. DIA 2016-146), Family Ernfors Foundation
   (grant no. 160504), Uppsala-Orebro Regional Research Council, Gillberg
   Foundation (Uppsala, Sweden), and Swedish Research Council (Dnr
   2016-01040). The study has received funding from EXODIAB, the Swedish
   Society for Diabetology, and the Selander Foundation.
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   who, The WHO Child Growth Standards
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NR 32
TC 16
Z9 17
U1 0
U2 3
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0021-972X
EI 1945-7197
J9 J CLIN ENDOCR METAB
JI J. Clin. Endocrinol. Metab.
PD AUG
PY 2018
VL 103
IS 8
BP 2958
EP 2966
DI 10.1210/jc.2018-00194
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA GR0TT
UT WOS:000442236900022
PM 29850829
OA Bronze
DA 2025-06-11
ER

PT J
AU Keuper, M
   Sachs, S
   Walheim, E
   Berti, L
   Raedle, B
   Tews, D
   Fischer-Posovszky, P
   Wabitsch, M
   de Angelis, MH
   Kastenmüller, G
   Tschöp, MH
   Jastroch, M
   Staiger, H
   Hofmann, SM
AF Keuper, Michaela
   Sachs, Stephan
   Walheim, Ellen
   Berti, Lucia
   Raedle, Bernhard
   Tews, Daniel
   Fischer-Posovszky, Pamela
   Wabitsch, Martin
   de Angelis, Martin Hrabe
   Kastenmueller, Gabi
   Tschop, Matthias H.
   Jastroch, Martin
   Staiger, Harald
   Hofmann, Susanna M.
TI Activated macrophages control human adipocyte mitochondrial
   bioenergetics via secreted factors
SO MOLECULAR METABOLISM
LA English
DT Article
DE Cytokines; Oxidative phosphorylation; Glycolysis; Cellular metabolism
ID ADIPOSE-TISSUE MACROPHAGES; NECROSIS-FACTOR-ALPHA; DIET-INDUCED OBESITY;
   SOLUBLE CD40 LIGAND; INSULIN SENSITIVITY; GENE-EXPRESSION; ADIPONECTIN
   SECRETION; OXIDATIVE STRESS; FAT; CELLS
AB Objective: Obesity-associated WAT inflammation is characterized by the accumulation and local activation of macrophages (M Phi s), and recent data from mouse studies suggest that macrophages are modifiers of adipocyte energy metabolism and mitochondrial function. As mitochondria! dysfunction has been associated with obesity and the metabolic syndrome in humans, herein we aimed to delineate how human macrophages may affect energy metabolism of white adipocytes.
   Methods: Human adipose tissue gene expression analysis for markers of macrophage activation and tissue inflammation (CD11c, CD40, CD163, CD206, CD80, MCP1, TNF alpha) in relationship to mitochondrial complex I (NDUFB8) and complex III (UQCRC2) was performed on subcutaneous WAT of 24 women (BMI 20-61 kg/m(2)). Guided by these results, the impact of secreted factors of LPS/IFN gamma-and IL10/TGF beta-activated human macrophages (THP1, primary blood-derived) on mitochondrial function in human subcutaneous white adipocytes (SGBS, primary) was determined by extracellular flux analysis (Seahorse technology) and gene/protein expression.
   Results: Stepwise regression analysis of human WAT gene expression data revealed that a linear combination of CD40 and CD163 was the strongest predictor for mitochondrial complex I (NDUFB8) and complex III (UQCRC2) levels, independent of BMI. IL10/TGF beta-activated MIs displayed high CD163 and low CD40 expression and secreted factors that decreased UQCRC2 gene/protein expression and ATP-linked respiration in human white adipocytes. In contrast, LPS/IFN gamma-activated MIs showed high CD40 and low CD163 expression and secreted factors that enhanced adipocyte mitochondria, activity resulting in a total difference of 37% in ATP-linked respiration of white adipocytes (p = 0.0024) when comparing the effect of LPS/IFN gamma-vs IL10/TGF beta-activated M Phi s.
   Conclusion: Our data demonstrate that macrophages modulate human adipocyte energy metabolism via an activation-dependent paracrine mechanism. (C) 2017 The Authors. Published by Elsevier GmbH.
C1 [Keuper, Michaela; Sachs, Stephan; Hofmann, Susanna M.] German Res Ctr Environm Hlth GmbH, Helmholtz Zentrum Muenchen, Inst Diabet & Regenerat Res, Neuherberg, Germany.
   [Keuper, Michaela; Sachs, Stephan; Walheim, Ellen; Berti, Lucia; Raedle, Bernhard; de Angelis, Martin Hrabe; Tschop, Matthias H.; Jastroch, Martin; Staiger, Harald; Hofmann, Susanna M.] German Ctr Diabet Res DZD, Neuherberg, Germany.
   [Keuper, Michaela; Raedle, Bernhard; de Angelis, Martin Hrabe] German Res Ctr Environm Hlth GmbH, Helmholtz Zentrum Muenchen, Inst Expt Genet, Neuherberg, Germany.
   [Walheim, Ellen; Jastroch, Martin] German Res Ctr Environm Hlth GmbH, Helmholtz Zentrum Muenchen, Inst Diabet & Obes, Neuherberg, Germany.
   [Berti, Lucia; Staiger, Harald] Univ Tubingen, Helmholtz Ctr Munich, Inst Diabet Res & Metab Dis, Tubingen, Germany.
   [Tews, Daniel; Fischer-Posovszky, Pamela; Wabitsch, Martin] Univ Med Ctr, Dept Pediat & Adolescent Med, Div Pediat Endocrinol & Diabet, Ulm, Germany.
   [de Angelis, Martin Hrabe] Tech Univ Munich, Sch Life Sci Weihenstephan, Chair Expt Genet, Alte Akad 8, D-85354 Freising Weihenstephan, Germany.
   [Kastenmueller, Gabi] German Res Ctr Environm Hlth GmbH, Helmholtz Zentrum Muenchen, Inst Bioinformat & Syst Biol, Neuherberg, Germany.
   [Staiger, Harald] Eberhard Karls Univ Tubingen, Dept Pharm & Biochem, Inst Pharmaceut Sci, Tubingen, Germany.
   [Hofmann, Susanna M.] Klinikum LMU, Med Klin, Munich, Germany.
   [Hofmann, Susanna M.] Klinikum LMU, Poliklin 4, Munich, Germany.
C3 Helmholtz Association; Helmholtz-Center Munich - German Research Center
   for Environmental Health; German Center for Diabetes Research (DZD);
   Helmholtz Association; Helmholtz-Center Munich - German Research Center
   for Environmental Health; Helmholtz Association; Helmholtz-Center Munich
   - German Research Center for Environmental Health; Eberhard Karls
   University of Tubingen; Helmholtz Association; Helmholtz-Center Munich -
   German Research Center for Environmental Health; Ulm University;
   Technical University of Munich; Helmholtz Association; Helmholtz-Center
   Munich - German Research Center for Environmental Health; Eberhard Karls
   University of Tubingen; University of Munich; University of Munich
RP Keuper, M (corresponding author), German Res Ctr Environm Hlth GmbH, Ingolstaedter Landstr 1, D-85764 Neuherberg, Germany.
EM michaela.keuper@helmholtz-muenchen.de
RI Staiger, Harald/N-5871-2014; Tews, Daniel/HNJ-3520-2023; Tschoep,
   Matthias/I-5443-2014; Jastroch, Martin/I-7494-2017; Keuper,
   Michaela/JAN-4435-2023; Kastenmüller, Gabi/ABF-5987-2020; Hrabe de
   Angelis, Martin/F-5531-2012; Fischer-Posovszky, Pamela/D-5815-2016;
   Hofmann, Susanna/F-2654-2014
OI Kastenmuller, Gabi/0000-0002-2368-7322; Staiger,
   Harald/0000-0002-9507-5333; Hrabe de Angelis,
   Martin/0000-0002-7898-2353; Fischer-Posovszky,
   Pamela/0000-0003-3402-9840; Keuper, Michaela/0000-0003-0319-3509;
   Hofmann, Susanna/0000-0001-7682-5840
FU Helmholtz Alliance ICEMED (Imaging and Curing Environmental Metabolic
   Diseases); Network Fund of the Helmholtz Association; German Center for
   Diabetes Research; Deutsche Forschungsgemeinschaft [DFG: SFB1123-A4,
   DFG: Fi 1700/5-1, DFG: TE 912/2-1]; Ministry of Science, Research and
   the Arts of Baden-Wurttemberg (Boehringer Ingelheim University Ulm
   Biocenter (BIU)) [Az: 32-7533.-6-10/15/5]
FX This work was funded (in part) by the Helmholtz Alliance ICEMED (Imaging
   and Curing Environmental Metabolic Diseases), the Network Fund of the
   Helmholtz Association and the German Center for Diabetes Research (DZD),
   and by grants from the Deutsche Forschungsgemeinschaft to SMH (DFG:
   SFB1123-A4), to PFP (DFG: Fi 1700/5-1), and to DT (DFG: TE 912/2-1). DT
   was supported by a grant from the Ministry of Science, Research and the
   Arts of Baden-Wurttemberg (Boehringer Ingelheim University Ulm Biocenter
   (BIU) Az: 32-7533.-6-10/15/5).
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NR 91
TC 27
Z9 29
U1 0
U2 7
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2212-8778
J9 MOL METAB
JI Mol. Metab.
PD OCT
PY 2017
VL 6
IS 10
BP 1226
EP 1239
DI 10.1016/j.molmet.2017.07.008
PG 14
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA FR5CI
UT WOS:000419083700015
PM 29031722
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Rouhi-Boroujeni, H
   Heidarian, E
   Rouhi-Boroujeni, H
   Deris, F
   Rafieian-Kopaei, M
AF Rouhi-Boroujeni, Hojjat
   Heidarian, Esfandiar
   Rouhi-Boroujeni, Hamid
   Deris, Fatemeh
   Rafieian-Kopaei, Mahmoud
TI Medicinal Plants with Multiple Effects on Cardiovascular Diseases: A
   Systematic Review
SO CURRENT PHARMACEUTICAL DESIGN
LA English
DT Review
DE eHyperlipidemia; obesity; hypertension; diabetes; medicinal plant
ID OXIDATIVE STRESS; HERBAL MEDICINES; BLOOD-PRESSURE; PHOSPHATIDATE
   PHOSPHOHYDROLASE; ANTIOXIDANT ACTIVITY; LIPID-ACCUMULATION;
   ANETHUM-GRAVEOLENS; METABOLIC SYNDROME; AQUEOUS EXTRACT; RISK-FACTORS
AB Introduction: Hyperlipidemia, obesity, hypertension, and diabetes are the most important risk factors for cardiovascular diseases. The aim of this systematic review article is to introduce the medicinal plants that exert significant clinical effects on hypertension, hyperlipidemia, obesity, and diabetes.
   Methods: In this review article, the international research databases including MEDLINE, Google scholar, EB-SCO, Academic Search, Web of Science, SciVerse, Scopus (SCOPUS), EBSCO, Academic Search, Cochrane, Central Register of Controlled Trials (CENTRAL) and a Chinese database (China Network Knowledge Infrastructure [CNKI]) were searched using the key words hyperlipidemia, hypertension, diabetes, herbal, obesity, and phytomedicine, matched by MESH, from their respective inceptions up to March, 2016. The plants that were effective on one, two, three, or all of four diseases were determined. The doses, side effects, the most important pharmaceutically effective compounds, the used organs, and important points regarding usage were separately recorded. Also known clinically significant interactions were presented.
   Results: 1023 articles were found to be about medicinal plants and hypertension, 1912 articles about medicinal plants and hyperlipidemia, 810 articles about medicinal plants and obesity, 1174 articles about medicinal plants and diabetes. Of 144 plants included in the analysis, 83 were found to be effective on hyperlipidemia, 100 on hypertension, 66 on obesity, and 72 on diabetes. 43 plants were found to be effective on two diseases, 14 on three diseases, and 34 on all four diseases. Three plants (Tomato, Cranberry and Pomegranate), in food and therapeutic doses, were found to be used to treat cardiovascular diseases especially in pre-eclampsia and hyperlipidemia in pregnancy.
   Conclusion: Regarding the findings of this study, we can argue that the medicinal plants, other than mono-therapy, can be used as poly-therapy, to treat cardiovascular diseases.
C1 [Rouhi-Boroujeni, Hojjat] Shahrekord Univ Med Sci, Student Res Comm, Shahrekord, Iran.
   [Heidarian, Esfandiar; Rouhi-Boroujeni, Hamid] Shahrekord Univ Med Sci, Clin Biochem Res Ctr, Shahrekord, Iran.
   [Deris, Fatemeh; Rafieian-Kopaei, Mahmoud] Shahrekord Univ Med Sci, Med Plants Res Ctr, Shahrekord, Iran.
C3 Shahrekord University Medical Sciences; Shahrekord University Medical
   Sciences; Shahrekord University Medical Sciences
RP Rafieian-Kopaei, M (corresponding author), Shahrekord Univ Med Sci, Med Plants Res Ctr, Shahrekord, Iran.
EM rafieian@yahoo.com
RI Heidarian, Esfandiar/N-6732-2017; Deris, Fatemeh/J-9950-2017;
   Rafieian-Kopaei, Mahmoud/L-6532-2016; Boroujeni, Hamid/V-3087-2017
OI Rafieian-kopaei, Mahmoud/0000-0002-1860-1141
FU Shahrekord University of Medical Sciences, Iran
FX This article has been derived from the Ph.D. thesis of the first author
   and financially supported by the research deputy of Shahrekord
   University of Medical Sciences, Iran.
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NR 115
TC 68
Z9 72
U1 0
U2 52
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1381-6128
EI 1873-4286
J9 CURR PHARM DESIGN
JI Curr. Pharm. Design
PY 2017
VL 23
IS 7
BP 999
EP 1015
DI 10.2174/1381612822666161021160524
PG 17
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA ET7XL
UT WOS:000400512700005
PM 27774898
DA 2025-06-11
ER

EF﻿FN Clarivate Analytics Web of Science
VR 1.0
PT J
AU Wirth, J
   di Giuseppe, R
   Boeing, H
   Weikert, C
AF Wirth, J.
   di Giuseppe, R.
   Boeing, H.
   Weikert, C.
TI A Mediterranean-style diet, its components and the risk of heart
   failure: a prospective population-based study in a non-Mediterranean
   country
SO EUROPEAN JOURNAL OF CLINICAL NUTRITION
LA English
DT Article
ID RED MEAT CONSUMPTION; CARDIOVASCULAR-DISEASE; MYOCARDIAL-INFARCTION;
   METABOLIC SYNDROME; OXIDATIVE STRESS; FISH CONSUMPTION; DASH DIET;
   METAANALYSIS; PREVENTION; NUTRITION
AB BACKGROUND/OBJECTIVES: Growing evidence emerged about the role of diet in heart failure (HF) development, but data are sparse and inconclusive. We examined the association between a Mediterranean-style diet, its components and HF risk.
   SUBJECTS/METHODS: Analyses were carried out in 24 008 middle-aged participants of the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam (Germany), including 209 incident HF cases within 8.2 years. The traditional Greek Mediterranean diet score (tMED) was used to assess dietary adherence. Cox's proportional hazards regression was applied to estimate the relationship between the adherence to the Mediterranean-style diet, its components and HF risk.
   RESULTS: After adjustment for age, sex and energy intake, a 2-unit increment in the tMED was associated with 26% lower risk of HF (HR (95% confidence interval (CI)): 0.76 (0.60-0.97)). After multivariable adjustment, this association was slightly attenuated and lost significance [ HR (95% CI): 0.82 (0.64-1.05)]. Interestingly, we observed a significant association in multivariable adjusted models when milk products were excluded from the score (HR (95% CI): 0.75 (0.59-0.96)). Three score components were significantly associated with HF risk: alcohol (HR (95% CI): 0.73 (0.55-0.97) for moderate versus low/high intakes), meat: 2.04 (1.17-3.55) and fish: 0.59 (0.36-0.95), both for the highest versus the lowest quintile.
   CONCLUSIONS: The tMED was not significantly associated with HF risk, but low meat, high fish and moderate alcohol intake were inversely associated with HF risk in our non-Mediterranean population. Minor dietary changes could be valuable primary prevention measures, particularly the increase of fish consumption while reducing the intake of meat.
C1 [Wirth, J.] Harvard TH Chan Sch Publ Hlth, Dept Nutr, 655 Huntington Ave, Boston, MA 02115 USA.
   [Wirth, J.; di Giuseppe, R.; Boeing, H.; Weikert, C.] German Inst Human Nutr, Dept Epidemiol, Potsdam, Nuthetal, Germany.
   [Wirth, J.; di Giuseppe, R.; Weikert, C.] DZHK German Ctr Cardiovasc Res, Partner Site Berlin Potsdam, Potsdam, Germany.
   [di Giuseppe, R.] Univ Kiel, Inst Epidemiol, Kiel, Germany.
   [Weikert, C.] Charite Univ Med Ctr, Inst Social Med Epidemiol & Hlth Econ, Berlin, Germany.
   [Weikert, C.] Fed Inst Risk Assessment, Dept Food Safety, Berlin, Germany.
C3 Harvard University; Harvard T.H. Chan School of Public Health; Leibniz
   Association; Deutsches Institut fur Ernahrungsforschung
   Potsdam-Rehbrucke (DIfE); German Centre for Cardiovascular Research;
   University of Kiel; Berlin Institute of Health; Free University of
   Berlin; Humboldt University of Berlin; Charite Universitatsmedizin
   Berlin; Federal Institute for Risk Assessment
RP Wirth, J (corresponding author), Harvard TH Chan Sch Publ Hlth, Dept Nutr, 655 Huntington Ave, Boston, MA 02115 USA.
EM J.Wirth@hsph.harvard.edu
OI Wirth, Janine/0000-0001-7075-9686; di Giuseppe,
   Romina/0000-0002-5214-8897
FU Federal Ministry of Science, Germany [01 EA 9401]; European Union [SOC
   95201408 05F02]; German Cancer Aid [70-2488-Ha I]; European Community
   [SOC 98200769 05F02]
FX We thank the Human Study Centre (HSC) of the German Institute of Human
   Nutrition Potsdam-Rehbruecke, namely the trustee and the data hub for
   the processing, and the participants for the provision of the data, the
   biobank for the processing of the biological samples and the head of the
   HSC, Manuela Bergmann, for the contribution to the study design and
   leading the underlying processes of data generation. We are,
   furthermore, indebted to Wolfgang Bernigau for statistical support. The
   recruitment phase of the EPIC-Potsdam Study was supported by the Federal
   Ministry of Science, Germany (01 EA 9401) and the European Union (SOC
   95201408 05F02). The follow-up was supported by the German Cancer Aid
   (70-2488-Ha I) and the European Community (SOC 98200769 05F02).
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NR 47
TC 30
Z9 30
U1 1
U2 26
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0954-3007
EI 1476-5640
J9 EUR J CLIN NUTR
JI Eur. J. Clin. Nutr.
PD SEP
PY 2016
VL 70
IS 9
BP 1015
EP 1021
DI 10.1038/ejcn.2016.140
PG 7
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA DW6RX
UT WOS:000383779900008
PM 27507073
DA 2025-06-11
ER

PT J
AU Crujeiras, AB
   Casanueva, FF
AF Crujeiras, Ana B.
   Casanueva, Felipe F.
TI Obesity and the reproductive system disorders: epigenetics as a
   potential bridge
SO HUMAN REPRODUCTION UPDATE
LA English
DT Review
DE adipose tissue; DNA methylation; cancer; infertility; obesity
ID BODY-MASS INDEX; LIFE-STYLE FACTORS; DNA METHYLATION MAP; OXIDATIVE
   STRESS; METABOLIC SYNDROME; TRANSGENERATIONAL INHERITANCE;
   BREAST-CANCER; OLDER MEN; PROMOTER HYPERMETHYLATION; NATURAL MENOPAUSE
AB Background: Obesity and overweight are significantly involved in several reproductive pathologies contributing to infertility in men and women. In addition, several cancers of the reproductive system, such as endometrial, ovarian, breast, testicular and prostate cancers, are strongly influenced by obesity. However, the molecular mechanisms involved in the association between obesity and reproductive disorders remain unclear. Our proposal is to review the current scientific evidence regarding the effect of obesity-related factors as the core of the collective mechanisms directly and indirectly involved in the relationship between obesity and reproductive disorders, with a special and original focus on the effect of the obesity state microenvironment on the epigenetic profile as a reversible mechanistic link between obesity and the reproductive disorders.
   Methods: A PubMed search was performed using keywords related to obesity and adipose-related factors and epigenetics and associated with keywords related to reproduction. Full-text articles and abstracts in the English language published prior to 31 December 2013 were reviewed.
   Results: The obesity state notably contributes to a reproductive dysfunction in both men and women, ranging from infertility to oncological outcomes. Several epidemiological and experimental studies demonstrate that factors secreted by the adipose tissue and gut in an obesity state can directly induce reproductive disturbances. Relevantly, these same factors are able to alter the epigenetic regulation of genes, a dynamic and reversible mechanism by which the organism responds to environmental pressures critical to the reproductive function.
   Conclusion: This review outlines the evidence showing that the association between the reproductive pathologies and obesity is not inevitable but is potentially preventable and reversible. The epigenetic marks related to obesity could constitute a therapeutic target for the reproductive disorders associated with obesity.
C1 [Crujeiras, Ana B.; Casanueva, Felipe F.] CHUS, Inst Invest Sanitaria IDIS, Lab Mol & Cellular Endocrinol, Santiago De Compostela, Spain.
   [Crujeiras, Ana B.; Casanueva, Felipe F.] USC, Santiago De Compostela, Spain.
   [Crujeiras, Ana B.] Bellvitge Biomed Res Inst IDIBELL, Canc Epigenet & Biol Program PEBC, Barcelona, Spain.
   [Crujeiras, Ana B.; Casanueva, Felipe F.] CIBER Fisiopatol Obesidad & Nutr CIBERobn, Madrid, Spain.
C3 Complexo Hospitalario Universitario de Santiago de Compostela;
   Universidade de Santiago de Compostela; Institut d'Investigacio
   Biomedica de Bellvitge (IDIBELL); CIBER - Centro de Investigacion
   Biomedica en Red; CIBEROBN
RP Casanueva, FF (corresponding author), Complejo Hosp Santiago CHUS, Inst Invest Sanitaria, Mol & Cellular Endocrinol Area, Lab 2, C Choupana S-N, Santiago De Compostela 15706, Spain.
EM endocrine@usc.es
RI Crujeiras, Ana B/ABA-8866-2021
OI Crujeiras, Ana B/0000-0003-4392-0301
FU CIBERobn; INTRASALUD proyect, Instituto de Salud Carlos III (ISCIII)
   initiatives; Xunta de Galicia and Fundacion Lilly; ISCIII [C09/00365]
FX The authors' laboratory work is supported by CIBERobn and the INTRASALUD
   proyect, Instituto de Salud Carlos III (ISCIII) initiatives as well as
   the Xunta de Galicia and Fundacion Lilly. A.B.C. is funded by the ISCIII
   through a research contract 'Sara Borrell' (C09/00365).
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NR 164
TC 59
Z9 71
U1 1
U2 36
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1355-4786
EI 1460-2369
J9 HUM REPROD UPDATE
JI Hum. Reprod. Update
PD MAR-APR
PY 2015
VL 21
IS 2
BP 249
EP 261
DI 10.1093/humupd/dmu060
PG 13
WC Obstetrics & Gynecology; Reproductive Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology; Reproductive Biology
GA CC2BX
UT WOS:000350150800006
PM 25413685
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Montani, JP
   Schutz, Y
   Dulloo, AG
AF Montani, J. -P.
   Schutz, Y.
   Dulloo, A. G.
TI Dieting and weight cycling as risk factors for cardiometabolic diseases:
   who is really at risk?
SO OBESITY REVIEWS
LA English
DT Article; Proceedings Paper
CT 7th Fribourg Obesity Research Conference (FORC)
CY SEP 12, 2013
CL Univ Fribourg, Fac Sci, Fribourg, SWITZERLAND
SP Univ Fribourg, Dept Med
HO Univ Fribourg, Fac Sci
DE Diabetes; hypertension; obesity; weight cycling
ID BODY-WEIGHT; PHYSIOLOGICAL PROFILES; METABOLIC SYNDROME;
   EATING-DISORDERS; ADOLESCENT GIRLS; ENERGY-BALANCE; LOSE WEIGHT; US
   ADULTS; MORTALITY; PREVALENCE
AB Despite the poor prognosis of dieting in obesity management, which often results in repeated attempts at weight loss and hence weight cycling, the prevalence of dieting has increased continuously in the past decades in parallel to the steadily increasing prevalence of obesity. However, dieting and weight cycling are not limited to those who are obese or overweight as substantial proportions of the various population groups with normal body weight also attempt to lose weight. These include young and older adults as well as children and adolescents who perceive themselves as too fat (due to media, parental and social pressures), athletes in weight-sensitive competitive sports (i.e. mandatory weight categories, gravitational and aesthetic sports) or among performers for whom a slim image is professionally an advantage. Of particular concern is the emergence of evidence that some of the potentially negative health consequences of repeated dieting and weight cycling are more readily seen in people of normal body weight rather than in those who are overweight or obese. In particular, several metabolic and cardiovascular risk factors associated with weight cycling in normal-weight individuals have been identified from cross-sectional and prospective studies as well as from studies of experimentally induced weight cycling. In addition, findings from studies of experimental weight cycling have reinforced the notion that fluctuations of cardiovascular risk variables (such as blood pressure, heart rate, sympathetic activity, blood glucose, lipids and insulin) with probable repeated overshoots above normal values during periods of weight regain put an additional stress on the cardiovascular system. As the prevalence of diet-induced weight cycling is increasing due to the opposing forces of an 'obesigenic' environment and the media pressure for a slim figure (that even targets children), dieting and weight cycling is likely to become an increasingly serious public health issue.
C1 [Montani, J. -P.; Schutz, Y.; Dulloo, A. G.] Univ Fribourg, Dept Med, Div Physiol, CH-1700 Fribourg, Switzerland.
C3 University of Fribourg
RP Montani, JP (corresponding author), Univ Fribourg, Dept Med Physiol, Chemin Musee 5, CH-1700 Fribourg, Switzerland.
EM jean-pierre.montani@unifr.ch
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NR 118
TC 173
Z9 200
U1 1
U2 61
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1467-7881
EI 1467-789X
J9 OBES REV
JI Obes. Rev.
PD FEB
PY 2015
VL 16
SU 1
SI SI
BP 7
EP 18
DI 10.1111/obr.12251
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI); Conference Proceedings Citation Index - Science (CPCI-S)
SC Endocrinology & Metabolism
GA CC3XX
UT WOS:000350285800002
PM 25614199
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Zhang, QY
   Pan, Y
   Wang, R
   Kang, LL
   Xue, QC
   Wang, XN
   Kong, LD
AF Zhang, Qing-Yu
   Pan, Ying
   Wang, Rong
   Kang, Lin-Lin
   Xue, Qiao-Chu
   Wang, Xiao-Ning
   Kong, Ling-Dong
TI Quercetin inhibits AMPK/TXNIP activation and reduces inflammatory
   lesions to improve insulin signaling defect in the hypothalamus of high
   fructose-fed rats
SO JOURNAL OF NUTRITIONAL BIOCHEMISTRY
LA English
DT Article
DE Fructose; Quercetin; Hypothalamic insulin signaling; TXNIP; NLRP3
   inflammasome
ID THIOREDOXIN-INTERACTING PROTEIN; NLRP3 INFLAMMASOME; KAPPA-B;
   GLUCOSE-HOMEOSTASIS; LIPID-ACCUMULATION; METABOLIC SYNDROME; HEPATIC
   STEATOSIS; ENERGY IMBALANCE; OXIDATIVE STRESS; GENE-EXPRESSION
AB Fructose is a nutritional composition of fruits and honey. Its excess consumption induces insulin resistance-associated metabolic diseases. Hypothalamic insulin signaling plays a pivotal role in controlling whole-body insulin sensitivity and energy homeostasis. Quercetin, a natural flavonoid, has been reported to ameliorate high fructose-induced rat insulin resistance and hyperlipidemia. In this study, we investigated its regulatory effects on the hypothalamus of high fructose-fed rats. Rats were fed 10% fructose in drinking water for 10 weeks. After 4 weeks, these animals were orally treated with quercetin (50 and 100 mg/kg), allopurinol (5 mg/kg) and water daily for the next 6 weeks, respectively. Quercetin effectively restored high fructose-induced hypothalamic insulin signaling defect by up-regulating the phosphorylation of insulin receptor and protein kinase B. Furthermore, quercetin was found to reduce metabolic nutrient sensors adenosine monophosphate-activated protein kinase (AMPK) activation and thioredoxin-interacting protein (TXNIP) overexpression, as well as the glutamine-glutamate cycle dysfunction in the hypothalamus of high fructose-fed rats. Subsequently, it ameliorated high fructose-caused hypothalamic inflammatory lesions in rats by suppressing the activation of hypothalamic nuclear factor kappa B (NF-kappa B) pathway and NOD-like receptor 3 (NLRP3) inflammasome with interleukin 1 beta maturation. Allopurinol had similar effects. These results provide in vivo evidence that quercetin-mediated down-regulation of AMPK/TXNIP and subsequent inhibition of NF-kappa B pathway/NLRP3 inflammasome activation in the hypothalamus of rats may be associated with the reduction of hypothalamic inflammatory lesions, contributing to the improvement of hypothalamic insulin signaling defect in this model. Thus, quercetin with the central activity may be a therapeutic for high fructose-induced insulin resistance and hyperlipidemia in humans. (C) 2014 Elsevier Inc. All rights reserved.
C1 [Zhang, Qing-Yu; Pan, Ying; Wang, Rong; Kang, Lin-Lin; Xue, Qiao-Chu; Wang, Xiao-Ning; Kong, Ling-Dong] Nanjing Univ, Sch Life Sci, State Key Lab Pharmaceut Biotechnol, Nanjing 210093, Jiangsu, Peoples R China.
C3 Nanjing University
RP Pan, Y (corresponding author), Nanjing Univ, Sch Life Sci, State Key Lab Pharmaceut Biotechnol, Nanjing 210093, Jiangsu, Peoples R China.
EM pany@nju.edu.cn; kongld@nju.edu.cn
FU National Natural Science Foundation of China [NSFC 81025025, 81001671,
   J1103512]; Doctoral Program of Higher Education of China
   [RFDP20120091110039]
FX This work is supported by grants from National Natural Science
   Foundation of China (NSFC 81025025, 81001671 and J1103512) and the
   Doctoral Program of Higher Education of China (RFDP20120091110039).
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NR 55
TC 74
Z9 80
U1 0
U2 62
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0955-2863
EI 1873-4847
J9 J NUTR BIOCHEM
JI J. Nutr. Biochem.
PD APR
PY 2014
VL 25
IS 4
BP 420
EP 428
DI 10.1016/j.jnutbio.2013.11.014
PG 9
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA AD8JU
UT WOS:000333513100007
PM 24491314
DA 2025-06-11
ER

PT J
AU Ballard, KD
   Quann, EE
   Kupchak, BR
   Volk, BM
   Kawiecki, DM
   Fernandez, ML
   Seip, RL
   Maresh, CM
   Kraemer, WJ
   Volek, JS
AF Ballard, Kevin D.
   Quann, Erin E.
   Kupchak, Brian R.
   Volk, Brittanie M.
   Kawiecki, Diana M.
   Fernandez, Maria Luz
   Seip, Richard L.
   Maresh, Carl M.
   Kraemer, William J.
   Volek, Jeff S.
TI Dietary carbohydrate restriction improves insulin sensitivity, blood
   pressure, microvascular function, and cellular adhesion markers in
   individuals taking statins
SO NUTRITION RESEARCH
LA English
DT Article
DE Vascular endothelial function; Flow mediated dilation; Low-carbohydrate
   diets; Inflammation; Insulin resistance; Human
ID DENSITY-LIPOPROTEIN CHOLESTEROL; FLOW-MEDIATED DILATION; C-REACTIVE
   PROTEIN; ENDOTHELIAL FUNCTION; OXIDATIVE STRESS; HUMAN FOREARM; LOW-FAT;
   METABOLIC SYNDROME; SATURATED FAT; NITRIC-OXIDE
AB Statins positively impact plasma low-density lipoprotein cholesterol, inflammation and vascular endothelial function (VEF). Carbohydrate restricted diets (CRD) improve atherogenic dyslipidemia, and similar to statins, have been shown to favorably affect markers of inflammation and VEF. No studies have examined whether a CRD provides additional benefit beyond that achieved by habitual statin use. We hypothesized that a CRD (<50 g carbohydrate/d) for 6 weeks would improve lipid profiles and insulin sensitivity, reduce blood pressure, decrease cellular adhesion and inflammatory biomarkers, and augment VEF (flow-mediated dilation and forearm blood flow) in statin users. Participants (n = 21; 59.3 +/- 9.3 y, 29.5 +/- 3.0 kg/m(2)) decreased total caloric intake by approximately 415 kcal at 6 weeks (P < .001). Daily nutrient intakes at baseline (46/36/17% carb/fat/pro) and averaged across the intervention (11158/28% carb/fat/pro) demonstrated dietary compliance, with carbohydrate intake at baseline nearly 5-fold greater than during the intervention (P < .001). Compared to baseline, both systolic and diastolic blood pressure decreased after 3 and 6 weeks (P < .01). Peak forearm blood flow, but not flow-mediated dilation, increased at week 6 compared to baseline and week 3 (P < .03). Serum triglyceride, insulin, soluble E-Selectin and intracellular adhesion molecule-1 decreased (P < .01) from baseline at week 3, and this effect was maintained at week 6. In conclusion, these findings demonstrate that individuals undergoing statin therapy experience additional improvements in metabolic and vascular health from a 6 weeks CRD as evidenced by increased insulin sensitivity and resistance vessel endothelial function, and decreased blood pressure, triglycerides, and adhesion molecules. (C) 2013 Elsevier Inc. All rights reserved.
C1 [Ballard, Kevin D.; Quann, Erin E.; Kupchak, Brian R.; Volk, Brittanie M.; Kawiecki, Diana M.; Maresh, Carl M.; Kraemer, William J.; Volek, Jeff S.] Univ Connecticut, Dept Kinesiol, Storrs, CT 06269 USA.
   [Fernandez, Maria Luz] Univ Connecticut, Storrs, CT 06269 USA.
   [Seip, Richard L.] Hartford Hosp, Genet Res Ctr, Hartford, CT 06102 USA.
C3 University of Connecticut; University of Connecticut; Hartford Hospital
RP Volek, JS (corresponding author), Univ Connecticut, Dept Kinesiol, Storrs, CT 06269 USA.
EM jeff.volek@uconn.edu
RI Carl, Marx/B-2314-2012; Kupchak, Brian/K-2527-2015
OI Ballard, Kevin/0000-0001-7587-1220
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NR 37
TC 30
Z9 39
U1 0
U2 26
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0271-5317
J9 NUTR RES
JI Nutr. Res.
PD NOV
PY 2013
VL 33
IS 11
BP 905
EP 912
DI 10.1016/j.nutres.2013.07.022
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 251BG
UT WOS:000326902200004
PM 24176230
DA 2025-06-11
ER

PT J
AU Ordonez, FJ
   Fornieles-Gonzalez, G
   Camacho, A
   Rosety, MA
   Rosety, I
   Diaz, AJ
   Rosety-Rodriguez, M
AF Ordonez, Francisco J.
   Fornieles-Gonzalez, Gabriel
   Camacho, Alejandra
   Rosety, Miguel A.
   Rosety, Ignacio
   Diaz, Antonio J.
   Rosety-Rodriguez, Manuel
TI Anti-Inflammatory Effect of Exercise, via Reduced Leptin Levels, in
   Obese Women With Down Syndrome
SO INTERNATIONAL JOURNAL OF SPORT NUTRITION AND EXERCISE METABOLISM
LA English
DT Article
DE intellectual disability; aerobic training; obesity; adiponectin
ID NECROSIS-FACTOR-ALPHA; INTELLECTUAL DISABILITY; METABOLIC SYNDROME;
   OXIDATIVE STRESS; OLDER-PEOPLE; WEIGHT-LOSS; FAT MASS; ADULTS;
   INFLAMMATION; ADIPONECTIN
AB Recent studies have reported that obese young people with Down syndrome suffer from low-grade systemic inflammation. Whereas this condition may be improved in the general population by regular exercise, the problem has received no attention in the case of people with intellectual disability. Therefore, the authors' aim was to assess the influence of aerobic training on plasma adipokines in obese women with Down syndrome. Twenty obese young women with Down syndrome volunteered for this study, 11 of whom were randomly assigned to a 10-wk aerobic-training program. They attended 3 sessions/wk, which consisted of warm-up exercises followed by the main activity on a treadmill (30-40 min) at a work intensity of 55-65% of peak heart rate and ended with a cooling-down period. The control group included 9 women with Down syndrome matched for age, sex, and body-mass index. Fat-mass percentage and distribution were measured, and plasma adipokine levels (leptin and adiponectin) were assessed. In addition, each participant performed a maximal graded continuous treadmill exercise test. These parameters were assessed pre- and postintervention. Aerobic training produced a significant increase in participants' maximal oxygen uptake (20.2 +/- 5.8 vs.23.7 +/- 6.3 ml.kg(-1).min(-1); p < .001), and plasma leptin levels were significantly reduced in the intervention group (54.2 +/- 6.7 vs.45.7 +/- 6.1 ng/ml; p = .026). Further significant correlations between plasma leptin and indices of obesity were found. In contrast, no significant changes were found in adiponectin levels (p > .05). None of the tested parameters changed in the control group. In conclusion, a 10-week training program reduced leptin levels in obese young women with Down syndrome.
C1 [Ordonez, Francisco J.; Fornieles-Gonzalez, Gabriel; Rosety, Miguel A.; Rosety, Ignacio; Diaz, Antonio J.; Rosety-Rodriguez, Manuel] Univ Cadiz, Sch Sports Med, Cadiz, Spain.
   [Camacho, Alejandra] Hosp Juan Ramon Jimenez, Div Internal Med, Huelva, Spain.
C3 Universidad de Cadiz; Hospital Juan Ramon Jimenez
RP Ordonez, FJ (corresponding author), Univ Cadiz, Sch Sports Med, Cadiz, Spain.
RI ORDOÑEZ, FRANCISCO/W-7811-2018; ROSETY-RODRIGUEZ, MANUEL/ABE-8920-2020;
   Rodríguez, Miguel/AAT-1461-2020; Diaz, Antonio Jesus/HNJ-6099-2023;
   ROSETY-RODRIGUEZ, MANUEL/K-8821-2015
OI Ordonez, Francisco Javier/0000-0002-0191-503X; ROSETY-RODRIGUEZ,
   MANUEL/0000-0001-9631-2495
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NR 33
TC 16
Z9 16
U1 0
U2 19
PU HUMAN KINETICS PUBL INC
PI CHAMPAIGN
PA 1607 N MARKET ST, PO BOX 5076, CHAMPAIGN, IL 61820-2200 USA
SN 1526-484X
EI 1543-2742
J9 INT J SPORT NUTR EXE
JI Int. J. Sport Nutr. Exerc. Metab.
PD JUN
PY 2013
VL 23
IS 3
BP 239
EP 244
DI 10.1123/ijsnem.23.3.239
PG 6
WC Nutrition & Dietetics; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics; Sport Sciences
GA 163OT
UT WOS:000320347500005
PM 23307488
DA 2025-06-11
ER

PT J
AU Hosler, AS
   Nayak, SG
   Radigan, AM
AF Hosler, Akiko S.
   Nayak, Seema G.
   Radigan, Anne M.
TI Stressful events, smoking exposure and other maternal risk factors
   associated with gestational diabetes mellitus
SO PAEDIATRIC AND PERINATAL EPIDEMIOLOGY
LA English
DT Article
DE gestational diabetes; maternal smoking; maternal stress; life events
ID HOSPITAL DISCHARGE DATA; NEW-YORK-STATE; LIFE EVENTS; BIRTH CERTIFICATE;
   CIGARETTE-SMOKING; PREGNANT-WOMEN; CARDIOVASCULAR-DISEASE; METABOLIC
   SYNDROME; PREVALENCE; POPULATION
AB Hosler AS, Nayak SG, Radigan AM. Stressful events, smoking exposure and other maternal risk factors associated with gestational diabetes mellitus. Paediatric and Perinatal Epidemiology 2011; 25: 566-574.
   The incidence of gestational diabetes mellitus (GDM) has increased significantly in the last few decades in the US. Understanding its risk factors is imperative for the prevention of GDM and its sequelae, but the roles of behavioural risk factors such as stressful events and smoking on GDM are generally not well understood. Using data obtained from the New York State (NYS) Pregnancy Risk Assessment Monitoring System survey for 2004-06 and the NYS birth certificates, we examined relationships between GDM, stressful events and smoking among 2690 women who had live singleton births and did not have pre-pregnancy diabetes.
   After adjustment for risk factors such as maternal age, race/ethnicity, pre-pregnancy body mass index, hypertension, as well as smoking exposure, education, parity, and gestation at first visit for prenatal care, we found that having five or more stressful events 12 months before the baby was born was significantly associated with GDM (OR = 2.49, [95% CI 1.49, 4.16]). In another model, having any stressful event(s) other than 'moved to a new address' 12 months before the baby was born was also moderately associated with GDM (OR = 1.38, [95% CI 1.04, 1.85]). Smoking exposure, assessed by combining maternal smoking and second-hand smoke exposure into six levels, had no significant association with GDM, and did not show a dose-response pattern.
   The present study suggests that stressful events during pregnancy may be an independent risk factor for GDM. Future studies of GDM should include this common, but potentially modifiable risk factor in analyses.
C1 [Hosler, Akiko S.; Nayak, Seema G.] SUNY Albany, Sch Publ Hlth, Dept Epidemiol & Biostat, Rensselaer, NY 12144 USA.
   [Radigan, Anne M.] New York State Dept Hlth, Publ Hlth Informat Grp, Albany, NY USA.
C3 State University of New York (SUNY) System; University at Albany, SUNY;
   State University of New York (SUNY) System
RP Hosler, AS (corresponding author), SUNY Albany, Sch Publ Hlth, Dept Epidemiol & Biostat, GEC 147,1 Univ Pl, Rensselaer, NY 12144 USA.
EM ash05@health.state.ny.us
RI Hosler, Akiko/AAC-4184-2019
OI Hosler, Akiko/0000-0003-0642-1060; Nayak, Seema/0000-0003-1498-2079
FU University at Albany Faculty; University at Albany Center for Social and
   Demographic Analysis
FX This study was funded by the University at Albany Faculty Research
   Awards Program (Category A), and the University at Albany Center for
   Social and Demographic Analysis Junior Researcher Award.
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NR 41
TC 49
Z9 57
U1 0
U2 14
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0269-5022
EI 1365-3016
J9 PAEDIATR PERINAT EP
JI Paediatr. Perinat. Epidemiol.
PD NOV
PY 2011
VL 25
IS 6
BP 566
EP 574
DI 10.1111/j.1365-3016.2011.01221.x
PG 9
WC Public, Environmental & Occupational Health; Obstetrics & Gynecology;
   Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; Obstetrics & Gynecology;
   Pediatrics
GA 835IW
UT WOS:000296031100009
PM 21980946
DA 2025-06-11
ER

PT J
AU Kawamoto, R
   Kohara, K
   Tabara, Y
   Kusunoki, T
   Otsuka, N
   Miki, T
AF Kawamoto, Ryuichi
   Kohara, Katsuhiko
   Tabara, Yasuharu
   Kusunoki, Tomo
   Otsuka, Nobuyuki
   Miki, Tetsuro
TI Association between Serum Gamma-Glutamyl Transferase Level and
   Prehypertension among Community-Dwelling Men
SO TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE
LA English
DT Article
DE gamma-glutamyl transferase; hypertension; prehypertension; risk factor;
   Japanese men
ID BLOOD-PRESSURE; METABOLIC SYNDROME; HEART-DISEASE; GLUTAMYLTRANSFERASE;
   HYPERTENSION; RISK; POPULATION; PREVALENCE; EXPRESSION; PREDICTOR
AB Serum gamma-glutamyl transferase (GGT) activity is a general clinical marker of excessive alcohol consumption, and GGT reflects changes in oxidative stress and implicated in the progression of hypertension. Recent guidelines classify persons with above-optimal blood pressure (BP) but not clinical hypertension as having prehypertension for a systolic BP (SBP) of 120 to 139 mmHg and/or a diastolic BP (DBP) of 80 to 89 mmHg; however, only limited data are available on the association between serum GGT and this entity among community-dwelling men in Japan. We performed a cross-sectional study to examine whether serum GGT was associated with prehypertension. Study participants (754 men, age 56 15 years) without a clinical history of stroke, transient ischemic attack, myocardial infarction, angina, or retial failure were recruited from a single community. Thirty-seven percent of participants had prehypertension and 39.3% had hypertension. Multiple regression analysis using SBP and DBP as objective variables, adjusted for risk factors as explanatory variables, showed that log GGT was significantly and independently associated with elevated SBP (beta = 0.109, P = 0.006) and DBP (beta = 0.238, P < 0.001). Compared with participants in the lowest tertile of serum GGT (< 29 IU/L), the multivariate-adjusted odds ratio (OR) (95% CI) for prehypertension was 1.73 (1.06-2.81) for the middle tertile (29-53 IU/L) and 2.37 (1.31-4.31) for the highest tertile (> 53 IU/L). Moreover, the respective ORs for hypertension were 1.82 (1.04-3.18) and 3.11 (1.61-6.03). These results suggest that higher serum GGT levels are associated with prehypertension or hypertension in the general male population.
C1 [Kawamoto, Ryuichi; Kusunoki, Tomo; Otsuka, Nobuyuki] Seiyo Municipal Nomura Hosp, Dept Internal Med, Seiyo City, Ehime 7971212, Japan.
   [Kohara, Katsuhiko; Tabara, Yasuharu; Miki, Tetsuro] Ehime Univ, Sch Med, Dept Geriatr Med, Matsuyama, Ehime 790, Japan.
C3 Ehime University
RP Kawamoto, R (corresponding author), Seiyo Municipal Nomura Hosp, Dept Internal Med, 9-53 Nomura, Seiyo City, Ehime 7971212, Japan.
EM rykawamo@ehime.med.or.jp
FU Foundation for Development of Community, JapanF
FX This work was supported in part by a grant-in-aid from the Foundation
   for Development of Community, Japan (2008).
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NR 27
TC 14
Z9 14
U1 0
U2 2
PU TOHOKU UNIV MEDICAL PRESS
PI SENDAI
PA 2-1, SEIRYO-MACHI, AOBA-KU, SENDAI, MIYAGI 980-8575, JAPAN
SN 0040-8727
EI 1349-3329
J9 TOHOKU J EXP MED
JI Tohoku J. Exp. Med.
PD NOV
PY 2008
VL 216
IS 3
BP 213
EP 221
DI 10.1620/tjem.216.213
PG 9
WC Medicine, General & Internal; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Research & Experimental Medicine
GA 372PH
UT WOS:000260913000003
PM 18987455
OA Bronze
DA 2025-06-11
ER

PT J
AU Kumar, A
   Aravamudhan, S
   Gordic, M
   Bhansali, S
   Mohapatra, SS
AF Kumar, Arun
   Aravamudhan, Shyarn
   Gordic, Milorad
   Bhansali, Shekhar
   Mohapatra, Shyam S.
TI Ultrasensitive detection of cortisol with enzyme fragment
   complementation technology using functionalized nanowire
SO BIOSENSORS & BIOELECTRONICS
LA English
DT Article; Proceedings Paper
CT 9th World Congress on Biosensors
CY MAY 10-12, 2006
CL Toronto, CANADA
DE nanowire; cortisol; steroid; covalent linkage; microfluid device
ID SALIVARY CORTISOL; SYMPTOMS; OBESITY; DISEASE; RATIO
AB Cortisol is a member of the glucocorticoid hormone family and a key metabolic regulator. Increased intracellular cortisol levels have been implicated in type 2 diabetes, obesity, and metabolic syndrome. Cortisol is an important bio-marker of stress and its detection is also important in sports medicine. However, rapid methods for sensitive detection of cortisol are limited. Functionalized gold nanowires were used to enhance the sensitivity and selectivity of cortisol detection. Gold nanowires are used to improve the electron transfer between the electrodes. Moreover, the large surface to volume ratio, small diffusion time and high electrical conductivity and their aligned nature will enhance the sensitivity and detection limit of the biosensor several fold. The biosensor was fabricated using, aligned gold (Au) nanowires to behave as the working electrode, platinum deposited on a silicon chip to function as the counter electrode, and silver/silver chloride as reference electrode. The gold nanowires were coupled with cortisol antibodies using covalent linkage chemistry and a fixed amount of 3 alpha-hydroxysteroid dehydrogenase was introduced into the reaction cell during each measurement to convert (reduce) ketosteroid into hydroxyl steroid. Furthermore, the micro-fluidic, micro-fluid part of the sensor was fabricated using micro-electro-mechanical system (MEMS) technology to have better control on liquid flow over Au nanowires to minimize the signal to noise ratio. The biosensor was characterized using SEM, AFM and FTIR technique. The response curve of the biosensor was found to be linear in the range of 10-80 mu M of cortisol. Moreover, the presence of hydrocortisone is sensitively detected in the range of 5-30 mu M. It is concluded that the functionalized gold nanowires with micro-fluidic device using enzyme fragment complementation technology can provide an easy and sensitive assay for cortisol detection in serum and other biological fluids. (c) 2006 Published by Elsevier B.V.
C1 Univ S Florida, Coll Med, Dept Internal Med, Div Allergy & Clin Immunol, Tampa, FL 33612 USA.
   Univ S Florida, Dept Elect Engn, BioMEMS, Tampa, FL 33620 USA.
   Univ S Florida, Dept Elect Engn, Microsyst Lab, Tampa, FL 33620 USA.
C3 State University System of Florida; University of South Florida; State
   University System of Florida; University of South Florida; State
   University System of Florida; University of South Florida
RP Mohapatra, SS (corresponding author), Univ S Florida, Coll Med, Dept Internal Med, Div Allergy & Clin Immunol, Tampa, FL 33612 USA.
EM smohapat@health.usf.edu
RI Aravamudhan, Shyam/A-8115-2009; Mohapatra, Shyam/C-2500-2012; Bhansali,
   Shekhar/E-4705-2010
OI Bhansali, Shekhar/0000-0001-5871-9163
FU NHLBI NIH HHS [HL071110-02] Funding Source: Medline
CR Abdallah BM, 2005, EUR J CLIN INVEST, V35, P627, DOI 10.1111/j.1365-2362.2005.01552.x
   Appel D, 2005, ANAL BIOANAL CHEM, V383, P182, DOI 10.1007/s00216-005-0022-9
   Boote JJ, 2005, NANOTECHNOLOGY, V16, P1500, DOI 10.1088/0957-4484/16/9/015
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NR 23
TC 58
Z9 71
U1 2
U2 77
PU ELSEVIER ADVANCED TECHNOLOGY
PI OXFORD
PA OXFORD FULFILLMENT CENTRE THE BOULEVARD, LANGFORD LANE, KIDLINGTON,
   OXFORD OX5 1GB, OXON, ENGLAND
SN 0956-5663
EI 1873-4235
J9 BIOSENS BIOELECTRON
JI Biosens. Bioelectron.
PD APR 15
PY 2007
VL 22
IS 9-10
BP 2138
EP 2144
DI 10.1016/j.bios.2006.09.035
PG 7
WC Biophysics; Biotechnology & Applied Microbiology; Chemistry, Analytical;
   Electrochemistry; Nanoscience & Nanotechnology
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Biophysics; Biotechnology & Applied Microbiology; Chemistry;
   Electrochemistry; Science & Technology - Other Topics
GA 154XN
UT WOS:000245541600045
PM 17097283
DA 2025-06-11
ER

PT J
AU Zheng, YZ
   Wei, W
   Wang, YK
   Li, TT
   Wei, YD
   Gao, S
AF Zheng, Yizhe
   Wei, Wei
   Wang, Yukun
   Li, Tingting
   Wei, Yundong
   Gao, Si
TI Gypenosides exert cardioprotective effects by promoting mitophagy and
   activating PI3K/Akt/GSK-3β/Mcl-1 signaling
SO PEERJ
LA English
DT Article
DE Gypenosides; GSK-3 beta; Heart failure; Mcl-1; Mitochondria; Mitophagy;
   PI3K/Akt pathway
ID ISCHEMIA-REPERFUSION INJURY; GYNOSTEMMA-PENTAPHYLLUM; MITOCHONDRIA;
   GSK-3-BETA; APOPTOSIS; PATHWAY; DEHYDROGENASE; CROSSTALK; PROTECTS;
   STRESS
AB Background. Gynostemma pentaphyllum (Thunb.) Makino, a well-known edible and medicinal plant, has anti-aging properties and is used to treataging-associated conditions such as diabetes, metabolic syndrome, and cardiovascular diseases. Gypenosides (GYPs) are the primary constituents of G. pentaphyllum. Increasing evidence indicates that GYPs are effective at preserving mitochondrial homeostasis and preventing heart failure (HF). This study aimed to uncover the cardioprotective mechanisms of GYPs related to mitochondrial regulation. Methods. The bioactive components in GYPs and the potential targets in treating HF were obtained and screened using the network pharmacology approach, followed by drug-disease target prediction and enrichment analyses. The pharmacological effects of GYPs in cardioprotection, mitochondrial function, mitochondrial quality control, and underlying mechanisms were further investigated in Doxorubicin (Dox)-stimulated Results. A total of 88 bioactive compounds of GYPs and their respective 71 drug-disease targets were identified. The hub targets covered MAPK, EGFR, PI3KCA, and Mcl-1. Enrichment analysis revealed that the pathways primarily contained PI3K/Akt, MAPK, and FoxO signalings, as well as calcium regulation, protein phosphorylation, apoptosis, and mitophagy process. In Dox-stimulated H9c2 rat cardiomyocytes, pretreatment with GYPs increased cell viability, enhanced cellular ATP content, restored basal oxygen consumption rate (OCR), and improved mitochondrial membrane potential (MMP). Furthermore, GYPs improved PINK1/parkin-mediated mitophagy without influencing mitochondrial fission/fusion proteins and the autophagic LC3 levels. Mechanistically, the phosphorylation of PI3K, Akt, GSK-3 beta, and the protein level of Mcl-1 was upregulated by GYP treatment. Conclusion. Our findings reveal that GYPs exert cardioprotective effects by rescuing the defective mitophagy, and PI3K/Akt/GSK-3 beta/Mcl-1 signaling is potentially involved in this process.
C1 [Zheng, Yizhe; Wei, Wei; Wang, Yukun; Li, Tingting; Wei, Yundong; Gao, Si] Guangxi Univ Sci & Technol, Sch Med, Dept Pharm, Liuzhou, Guangxi, Peoples R China.
   [Zheng, Yizhe] Shaanxi Prov Peoples Hosp, Dept Pharm, Xian, Shaanxi, Peoples R China.
   [Wei, Wei; Wang, Yukun] Guangxi Univ Sci & Technol, Sch Sci, Liuzhou, Guangxi, Peoples R China.
C3 Guangxi University of Science & Technology; Xi'an Medical University;
   Guangxi University of Science & Technology
RP Gao, S (corresponding author), Guangxi Univ Sci & Technol, Sch Med, Dept Pharm, Liuzhou, Guangxi, Peoples R China.
EM gaosi@gxust.edu.cn
RI Gao, Si/AHD-9391-2022; tingting, Li/JQV-7820-2023
FU National Natural Science Foundation of China [82160278, 82104563,
   81500214]; Guangxi Natural Science Foundation [2023GXNSFAA026209,
   2023GXNSFBA026166]; Doctoral Foundation of Guangxi University of Science
   and Technology [20Z23]; Graduate Innovation Project [GKYC202124]
FX This work was supported by grants from the National Natural Science
   Foundation of China (Nos. 82160278, 82104563, 81500214) , the Guangxi
   Natural Science Foundation (Nos. 2023GXNSFAA026209, 2023GXNSFBA026166) ,
   the Doctoral Foundation of Guangxi University of Science and Technology
   (No. 20Z23) , and Graduate Innovation Project (GKYC202124) . The funders
   had no role in study design, data collection and analysis, decision to
   publish, or preparation of the manuscript.
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NR 60
TC 3
Z9 3
U1 6
U2 11
PU PEERJ INC
PI LONDON
PA 341-345 OLD ST, THIRD FLR, LONDON, EC1V 9LL, ENGLAND
SN 2167-8359
J9 PEERJ
JI PeerJ
PD JUN 20
PY 2024
VL 12
AR 17538
DI 10.7717/peerj.17538
PG 23
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA XL1G2
UT WOS:001261742100001
PM 38912051
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Zhang, YM
   Lu, WH
   Li, XX
   Wang, Y
   Li, L
   Dai, YF
   Yang, HY
   Wang, Y
AF Zhang, Yumeng
   Lu, Wenhan
   Li, Xiaoxue
   Wang, Yu
   Li, Lin
   Dai, Yifan
   Yang, Haiyuan
   Wang, Ying
TI Mfat-1 ameliorates cachexia after hypoxic-ischemic brain damage
   in mice by protecting the hypothalamus-pituitary-adrenal axis
SO LIFE SCIENCES
LA English
DT Article
DE Mfat-1; Hypoxic-ischemic brain damage; Cachexia; Catabolic
ID STROKE; EXPRESSION; PATHOPHYSIOLOGY; MYOSTATIN; PROFILE; TRIAL
AB Aims: Cachexia, a metabolic syndrome, affects 21 % of patients suffering from ischemic encephalopathy. However, the specific mechanism and prevention measures are still unclear. Omega-3 polyunsaturated fatty acids (n-3 PUFAs) have been proven to reduce inflammatory cytokine levels during ischemic events, but whether they have a protective effect against cachexia after hypoxic-ischemic brain damage (HIBD) remains unclear.Main methods: C57BL/6J wild-type and mfat-1 transgenic male mice were treated with and without HIBD. One day after HIBD, the epididymal white fat, gastrocnemius muscle and hypothalamus were weighed and analyzed the phenotypic changes. RNA sequencing was applied to gastrocnemius muscle to identify differential genes and pathways in HIBD groups. The effect of HPA axis on cachexia post-HIBD was examined via adrenalectomy, dexamethasone (0.1 mg/kg), and corticosterone injection (100 mg/kg).Key findings: The results showed that the incidence of cachexia in mfat-1 mice, which produce high proportion of n-3 PUFAs, was significantly lower than that in wild-type mice post-HIBD. Cachexia-related factors, such as inflammation, muscle atrophy and lipid metabolism were significantly improved in mfat-1 HIBD. RNA sequencing revealed that catabolic and proteasome pathways were significantly downregulated. In hypothalamus, inflammatory cytokines, lipid peroxidation levels were reduced. Corticosterone, glucocorticoid receptor, and dexamethasone suppression test all showed that mfat-1 improved the dysfunction of the HPA axis post-HIBD. The present study elucidated for the first time that mfat-1 reduced HIBD-induced hyperactivation of the HPA axis in mice by reducing inflammation and oxidative stress and contributed to the reduction of metabolic imbalance in peripheral tissues.Significance: Our study provides mechanistic information for the development of intervention strategies to prevent cachexia.
C1 [Zhang, Yumeng; Lu, Wenhan; Li, Xiaoxue; Li, Lin; Dai, Yifan; Yang, Haiyuan; Wang, Ying] Nanjing Med Univ, Sch Basic Med Sci, Dept Med Genet, Nanjing 211166, Peoples R China.
   [Zhang, Yumeng; Lu, Wenhan; Li, Xiaoxue; Li, Lin; Dai, Yifan; Yang, Haiyuan; Wang, Ying] Nanjing Med Univ, Jiangsu Key Lab Xenotransplantat, Nanjing 211166, Peoples R China.
   [Dai, Yifan; Yang, Haiyuan; Wang, Ying] Nanjing Med Univ, Collaborat Innovat Ctr Cardiovasc Dis Translat Med, Key Lab Targeted Intervent Cardiovasc Dis, Nanjing 211166, Peoples R China.
   [Dai, Yifan] Nanjing Med Univ, State Key Lab Reprod Med, Nanjing 211166, Peoples R China.
   [Wang, Yu] Tianjin Univ Tradit Chinese Med, Sch Integrat Med, Tianjin 301617, Peoples R China.
C3 Nanjing Medical University; Nanjing Medical University; Nanjing Medical
   University; Nanjing Medical University; Tianjin University of
   Traditional Chinese Medicine
RP Yang, HY; Wang, Y (corresponding author), Nanjing Med Univ, Sch Basic Med Sci, Dept Med Genet, Nanjing 211166, Peoples R China.
EM hyyang@njmu.edu.cn; ywang@njmu.edu.cn
FU National Natural Science Foundation of China [31701283, 81970164];
   Jiangsu Key Laboratory of Xenotransplantation [BM2012116]
FX This work was supported by grants from the National Natural Science
   Foundation of China (31701283 81970164) , and the Jiangsu Key Laboratory
   of Xenotransplantation (BM2012116) .
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NR 47
TC 3
Z9 3
U1 3
U2 8
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0024-3205
EI 1879-0631
J9 LIFE SCI
JI Life Sci.
PD NOV 15
PY 2023
VL 333
AR 122172
DI 10.1016/j.lfs.2023.122172
EA OCT 2023
PG 13
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA Y3SQ1
UT WOS:001104502900001
PM 37832632
DA 2025-06-11
ER

PT J
AU Shahanoor, Z
   Sultana, R
   Savenkova, M
   Karatsoreos, IN
   Romeo, RD
AF Shahanoor, Ziasmin
   Sultana, Razia
   Savenkova, Marina
   Karatsoreos, Ilia N.
   Romeo, Russell D.
TI Metabolic dysfunctions following chronic oral corticosterone are
   modified by adolescence and sex in mice
SO PHYSIOLOGY & BEHAVIOR
LA English
DT Article
DE Adolescence; Sex differences; C57BL; 6N; Mouse; Corticosterone
ID OBESITY; NEURONS; STRESS; ORGANIZATION; PREVALENCE; BEHAVIORS; HORMONES;
   PUBERTY; NUMBER; TRENDS
AB Adolescence is a period of development in which shifts in responses to glucocorticoids is well-documented. Obesity and metabolic syndrome are substantial health issues whose rates continue to rise in both adult and adolescent populations. Though many interacting factors contribute to these dysfunctions, how these shifts in glucocorticoid responses may be related remain unknown. Using a model of oral corticosterone (CORT) exposure in male and female mice, we demonstrate differential responses during adolescence (30-58 days of age) or adulthood (70-98 day of age) in endpoints relevant to metabolic function. Our data indicate that CORT resulted in significant weight gain in adult-and adolescent-exposed females and adult-exposed males, but not adolescent-exposed males. Despite this difference, all animals treated with high levels of CORT showed significant increases in white adipose tissue, indicating a dissociation between weight gain and adiposity in adolescent-treated males. Similarly, all experimental groups showed significant increases in plasma insulin, leptin, and triglyceride levels, further suggesting potential disconnects between overt weight gain, and underlying metabolic dysregulation. Finally, we found age-and dose-dependent changes in the expression of hepatic genes important in glucocor-ticoid receptor and lipid regulation, which showed different patterns in males and females. Thus, altered tran-scriptional pathways in the liver might be contributing differentially to the similar metabolic phenotype observed among these experimental groups. We also show that despite little CORT-induced changes in the hypothalamic levels of orexin-A and NPY, we found that food and fluid intake were elevated in adolescent-treated males and females. These data indicate chronic exposure to elevated glucocorticoid levels results in metabolic dysfunction in both males and females, which can be further modulated by developmental stage.
C1 [Shahanoor, Ziasmin; Sultana, Razia; Romeo, Russell D.] Columbia Univ, Dept Psychol, Barnard Coll, New York, NY 10027 USA.
   [Shahanoor, Ziasmin; Sultana, Razia; Romeo, Russell D.] Columbia Univ, Dept Neurosci & Behav, Barnard Coll, New York, NY 10027 USA.
   [Savenkova, Marina] Washington State Univ, Dept Integrat Physiol & Neurosci, Pullman, WA 99164 USA.
   [Karatsoreos, Ilia N.] Univ Massachusetts, Dept Psychol & Brain Sci, Amherst, MA 01003 USA.
C3 Barnard College; Columbia University; Columbia University; Barnard
   College; Washington State University; University of Massachusetts
   System; University of Massachusetts Amherst
RP Romeo, RD (corresponding author), Columbia Univ, Dept Psychol, Barnard Coll, New York, NY 10027 USA.; Romeo, RD (corresponding author), Columbia Univ, Dept Neurosci & Behav, Barnard Coll, New York, NY 10027 USA.
EM rromeo@barnard.edu
RI Savenkova, Marina/AAN-9927-2021; Karatsoreos, Ilia/AAR-8774-2020
FU Barnard College; NIH [DK119811]
FX This work was supported in part by a Faculty Research Grant from Barnard
   College (R.D.R.) and NIH DK119811 (I.N. K) .
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NR 42
TC 2
Z9 2
U1 0
U2 3
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0031-9384
EI 1873-507X
J9 PHYSIOL BEHAV
JI Physiol. Behav.
PD OCT 1
PY 2023
VL 269
AR 114289
DI 10.1016/j.physbeh.2023.114289
EA JUL 2023
PG 12
WC Psychology, Biological; Behavioral Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Behavioral Sciences
GA P1JG5
UT WOS:001048266500001
PM 37422081
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Günes, Y
   Fersahoglu, MM
   Bulut, NE
   Çakmak, A
   Ergin, A
   Teke, E
   Karatas, TC
   Sahin, A
   Sancak, S
AF Gunes, Yasin
   Fersahoglu, Mehmet Mahir
   Bulut, Nuriye Esen
   cakmak, Ahmet
   Ergin, Anil
   Teke, Emre
   Karatas, Tugba Caner
   Sahin, Aytac
   Sancak, Seda
TI Effects of Sleeve Gastrectomy on Pelvic Floor Disorders in Female
   Patients with Severe Obesity: a Prospective Study
SO OBESITY SURGERY
LA English
DT Article
DE Sleeve gastrectomy; Pelvic floor disorders; Urinary incontinence;
   Overactive bladder; Fecal incontinence
ID URINARY-TRACT FUNCTION; WEIGHT-LOSS SURGERY; FECAL INCONTINENCE;
   OVERACTIVE BLADDER; BARIATRIC SURGERY; RISK-FACTORS; GASTROINTESTINAL
   SYMPTOMS; STRESS-INCONTINENCE; METABOLIC SYNDROME; EATING BEHAVIOR
AB Introduction Obesity is associated with pelvic floor disorders (PFD). Sleeve gastrectomy (SG) is one of the most effective weight loss methods. Although SG has been found to improve urinary incontinence (UI) and overactive bladder (OAB), its impact on fecal incontinence (FI) remains controversial.
   Materials and Methods This prospective, randomized study involved 60 female patients with severe obesity who were randomly assigned to two groups: the SG group and the diet group. The SG group underwent SG, while the diet group received a low-calorie, low-lipid diet for 6 months. The patients' condition was assessed before and after the study using three questionnaires: the International Consultation on Incontinence Questionnaire-Female Lower Urinary Tract Symptoms (ICIQ-FLUTS), the Overactive Bladder 8-Question Awareness Tool (OAB-V8), and the Wexner Score (CCIS).
   Results After 6 months, the SG group had a significantly higher percentage of total weight loss (%TWL) compared to the diet group (p<0.01). Both groups showed a decrease in the ICIQ-FLUTS, OAB-V8, and CCIS scores (p<0.05). UI, OAB, and FI improved significantly in the SG group (p<0.05), but no improvement was observed in the diet group (p>0.05). The correlation between %TWL and PFD was statistically significant but weak, with the strongest correlation between %TWL and ICIQ-FLUTS score and the weakest correlation between %TWL and CCIS score (p<0.05).
   Conclusions We recommend bariatric surgery for the treatment of PFD. However, given the weak correlation between %TWL and PFD after SG, further research should explore factors other than %TWL that are effective in recovery, particularly in relation to FI.
C1 [Gunes, Yasin; Fersahoglu, Mehmet Mahir; Bulut, Nuriye Esen; Ergin, Anil; Karatas, Tugba Caner] Fatih Sultan Mehmet Training & Res Hosp, Dept Gen Surg, Hastane Sokak 1-8, TR-34752 Atasehir, Istanbul, Turkiye.
   [cakmak, Ahmet] Sinop Ataturk State Hosp, Dept Gen Surg, TR-57000 Sinop, Turkiye.
   [Teke, Emre] Haydarpasa Numune Training & Res Hosp, Dept Gen Surg, Tibbiye Cad 23, TR-34668 Atasehir, Istanbul, Turkiye.
   [Sahin, Aytac] Fatih Sultan Mehmet Training & Res Hosp, Dept Urol, Hastane Sokak 1-8, TR-34752 Atasehir, Istanbul, Turkiye.
   [Sancak, Seda] Fatih Sultan Mehmet Training & Res Hosp, Dept Internal Med Endocrinol & Metab Disorders, Hastane Sokak 1-8, TR-34752 Atasehir, Istanbul, Turkiye.
C3 Fatih Sultan Mehmet Training & Research Hospital; Sinop University;
   Sinop Ataturk State Hospital; Istanbul Haydarpasa Numune Training &
   Research Hospital; Fatih Sultan Mehmet Training & Research Hospital;
   Fatih Sultan Mehmet Training & Research Hospital
RP Günes, Y (corresponding author), Fatih Sultan Mehmet Training & Res Hosp, Dept Gen Surg, Hastane Sokak 1-8, TR-34752 Atasehir, Istanbul, Turkiye.
EM drysngunes@hotmail.com; fersahoglu@yahoo.com;
   nuriyeesenbulut@hotmail.com; drahmetcakmak@hotmail.com;
   dranilergin@gmail.com; dr.emreteke@gmail.com; cantubik91@gmail.com;
   draytacsahin@gmail.com; drsedasancak@gmail.com
RI teke, emre/JVZ-2178-2024; Fersahoglu, Mehmet/AFN-6377-2022; Güneş,
   Yasin/LOR-3409-2024; Sahin, Aytaç/HGF-1088-2022; ERGIN,
   ANIL/GRY-3095-2022
OI Teke, Emre/0000-0001-7597-6401; Gunes, Yasin/0000-0003-3951-0721; Caner
   Karatas, Tugba/0000-0003-2470-1883; CAKMAK, AHMET/0000-0001-8768-2267;
   ERGIN, ANIL/0000-0001-6450-7124
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NR 70
TC 2
Z9 2
U1 0
U2 1
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0960-8923
EI 1708-0428
J9 OBES SURG
JI Obes. Surg.
PD OCT
PY 2023
VL 33
IS 10
BP 3069
EP 3076
AR s11695-023-06725-w
DI 10.1007/s11695-023-06725-w
EA JUL 2023
PG 8
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA X0YO4
UT WOS:001026598900001
PM 37428362
DA 2025-06-11
ER

PT J
AU Ghosh, C
   Das, N
   Saha, S
   Kundu, T
   Sircar, D
   Roy, P
AF Ghosh, Chandrachur
   Das, Neeladrisingha
   Saha, Sarama
   Kundu, Tathagata
   Sircar, Debabrata
   Roy, Partha
TI Involvement of Cdkal1 in the etiology of type 2 diabetes mellitus and
   microvascular diabetic complications: a review
SO JOURNAL OF DIABETES AND METABOLIC DISORDERS
LA English
DT Review
DE Diabetes mellitus; Cdkal1; SNPs; Microvascular complications; beta cell
   regeneration; Inflammation
ID GENOME-WIDE-ASSOCIATION; MEAN PLATELET VOLUME; BETA-CELL; SUSCEPTIBILITY
   LOCI; INSULIN-RESISTANCE; METABOLIC SYNDROME; LYMPHOCYTE RATIO; GENES;
   RISK; VARIANTS
AB Diabetes Mellitus, being a polygenic disorder, have a set of risk genes involved in the onset of the insulin resistance, obesity and impaired insulin synthesis. Recent genome wide association studies (GWAS) shows the intimacy of CDK5 regulatory subunit Associated protein 1-Like 1 (Cdkal1) with the pathophysiology of the diabetes mellitus and its complications, although the exact molecular relation is still unknown. In this short review, we have summarized all the diverse biological roles of Cdkal1 in relation to the onset of diabetes mellitus. Variations in the Cdkal1 transcript are responsible for the accumulation of misfolded insulin and thus generating oxidative and ER stress in the pancreatic beta-cells, leading to their destruction. Recent studies have shown that Cdkal1 has an intrinsic thiomethyl transferase activity, which is essential for proper posttranslational processing of pre-proinsulin to produce mature insulin. Moreover, Cdkal1 has also been claimed as an endogenous inhibitor of cdk5, which prevents the cdk5-induced interruption in insulin synthesis through PDX1 translocation from nucleus to cytosol. Recent clinical studies have identified the risk single nucleotide polymorphisms (SNPs) of Cdkal1 as one of the root causes for the onset of diabetic complications. To the best of our knowledge, it is the first comprehensive review which elaborates most of the potential Cdkal1-dependent molecular mechanisms studied yet. In this review, we present a compiled and concise summary about all the diverse roles of Cdkal1 in the context of type 2 diabetes mellitus and its associated complications. This review will be helpful to target Cdkal1 as a potential option for the management of type 2 diabetes mellitus in future.
C1 [Ghosh, Chandrachur; Das, Neeladrisingha; Kundu, Tathagata; Roy, Partha] Indian Inst Technol Roorkee, Dept Biosci & Bioengn, Mol Endocrinol Lab, Roorkee 247667, Uttarakhand, India.
   [Saha, Sarama] All India Inst Med Sci Rishikesh, Dept Biochem, Rishikesh, Uttarakhand, India.
   [Sircar, Debabrata] Indian Inst Technol Roorkee, Dept Biosci & Bioengn, Plant Mol Biol Lab, Roorkee 247667, Uttarakhand, India.
C3 Indian Institute of Technology System (IIT System); Indian Institute of
   Technology (IIT) - Roorkee; All India Institute of Medical Sciences
   (AIIMS) Rishikesh; Indian Institute of Technology System (IIT System);
   Indian Institute of Technology (IIT) - Roorkee
RP Roy, P (corresponding author), Indian Inst Technol Roorkee, Dept Biosci & Bioengn, Mol Endocrinol Lab, Roorkee 247667, Uttarakhand, India.
EM partha.roy@bt.iitr.ac.in
RI Ghosh, Chandrachur/MHQ-1352-2025; Roy, Partha/GNP-6565-2022; Das,
   Neeladrisingha/GSI-6798-2022
OI Ghosh, Chandrachur/0000-0002-2508-9721
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NR 75
TC 13
Z9 15
U1 0
U2 7
PU SPRINGER INT PUBL AG
PI CHAM
PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND
EI 2251-6581
J9 J DIABETES METAB DIS
JI J. Diabetes Metab. Disord.
PD JUN
PY 2022
VL 21
IS 1
BP 991
EP 1001
DI 10.1007/s40200-021-00953-6
EA JAN 2022
PG 11
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA 1V2OI
UT WOS:000741908400002
PM 35673487
OA Green Published
DA 2025-06-11
ER

PT J
AU Liu, XH
   Shen, H
   Chen, MF
   Shao, J
AF Liu, Xiaohui
   Shen, Hong
   Chen, Mingfeng
   Shao, Jun
TI Clinical Relevance of Selenium with Liver Stiffness and Steatosis
   Detected by Transient Elastography in Adults
SO BIOLOGICAL TRACE ELEMENT RESEARCH
LA English
DT Article
DE Selenium; Liver stiffness; Liver steatosis; National Health and
   Nutrition Examination Survey
ID METABOLIC SYNDROME; OXIDATIVE STRESS; PLASMA SELENIUM; ASSOCIATION;
   MANAGEMENT; DIAGNOSIS; HEALTH; RISK
AB The associations between selenium and liver stiffness and steatosis remain uncertain. This study aimed to explore the clinical relevance of selenium with liver stiffness and steatosis in adults from the 2017-2018 National Health and Nutrition Examination Survey. Subjects with excessive alcohol consumption and hepatitis B or C infection were excluded. Liver stiffness and steatosis were detected by transient elastography. Dietary selenium intakes and blood selenium concentrations were included as exposures. In multivariate analysis without adjustment for obesity, higher dietary selenium intakes (tertile 3 vs. tertile 1) were positively associated with liver stiffness in females (odds ratio (95% confidence interval): 2.64 (1.88-3.70)), and were positively associated with liver steatosis overall (1.54 (1.20-1.97)) and also in males (1.55 (1.06-2.26)). In multivariate analysis without adjustment for obesity, higher blood selenium concentrations (tertile 3 vs. tertile 1) were positively associated with liver steatosis overall (1.33 (1.02-1.76)) and also in males (1.56 (1.13-2.16)). After further adjustment for obesity, the abovementioned associations remain significant between dietary selenium intakes and liver stiffness in females (2.29 (1.69-3.12)) and liver steatosis overall (1.37 (1.01-1.86)), and between blood selenium concentrations and liver steatosis in males (1.67 (1.25-2.21)). Dose-response analysis showed that the abovementioned associations were linear. However, dietary selenium intakes meeting the recommended daily allowance (>= 55 mu g/day) were not associated with liver stiffness (0.99 (0.62-1.55)) and steatosis (1.01 (0.69-1.49)). In conclusion, higher dietary selenium intakes and blood selenium concentrations were positively associated with liver stiffness and steatosis, and obesity may partially account for the observed associations.
C1 [Liu, Xiaohui; Shen, Hong; Chen, Mingfeng; Shao, Jun] Jiangsu Univ, Dept Ultrasound Diag, Peoples Hosp Kunshan 1, Affiliated Kunshan Hosp, 91,West Qianjin Rd, Kunshan 215300, Jiangsu, Peoples R China.
C3 Jiangsu University
RP Shao, J (corresponding author), Jiangsu Univ, Dept Ultrasound Diag, Peoples Hosp Kunshan 1, Affiliated Kunshan Hosp, 91,West Qianjin Rd, Kunshan 215300, Jiangsu, Peoples R China.
EM baitiantougua123@126.com
RI shen, hong/HTQ-6147-2023
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NR 42
TC 7
Z9 7
U1 0
U2 12
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0163-4984
EI 1559-0720
J9 BIOL TRACE ELEM RES
JI Biol. Trace Elem. Res.
PD JUL
PY 2022
VL 200
IS 7
BP 3041
EP 3049
DI 10.1007/s12011-021-02912-x
EA SEP 2021
PG 9
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 2D8KV
UT WOS:000692631900001
PM 34478060
DA 2025-06-11
ER

PT J
AU Naresh, S
   Bitla, AR
   Rao, PVLNS
   Sachan, A
   Amancharla, YL
AF Naresh, Sriram
   Bitla, Aparna R.
   Rao, P. V. L. N. Srinivasa
   Sachan, Alok
   Amancharla, Yadagiri Lakshmi
TI Efficacy of oral rosuvastatin intervention on HDL and its associated
   proteins in men with type 2 diabetes mellitus
SO ENDOCRINE
LA English
DT Article
DE Cholesterol efflux; High-density lipoprotein function; Myeloperoxidase;
   Oxidized high-density lipoprotein; Oxidized low density lipoprotein;
   Type 2 diabetes mellitus
ID CHOLESTEROL EFFLUX CAPACITY; INTIMA-MEDIA THICKNESS;
   DENSITY-LIPOPROTEIN; SUBCLINICAL ATHEROSCLEROSIS; METABOLIC SYNDROME;
   ATORVASTATIN; PLASMA; ACYLTRANSFERASE; SIMVASTATIN; DISEASE
AB Purpose High-density lipoprotein (HDL) undergoes structural and functional modification in patients with type 2 diabetes mellitus (T2DM). There are limited data on effect of rosuvastatin on HDL-associated proteins and the antiatherogenic effects of rosuvastatin. The present study intended to study the efficacy of rosuvastatin intervention on HDL-associated proteins and its other antiatherogenic effects in men with T2DM. Methods Men with T2DM on oral antidiabetic treatment, with LDL-C levels > 75 mg/dL and willing for rosuvastatin intervention (20 mg/day orally for a period of 12 weeks), were included. Fasting glucose, lipid profile were measured using standard methods. Oxidized low-density lipoprotein (oxLDL), oxidized HDL (oxHDL), paraoxonase-1 (PON-1), tumour necrosis factor-alpha (TNF-alpha) and lecithin:cholesterol acyltransferase (LCAT) in serum were measured by ELISA; serum myeloperoxidase (MPO) by spectrophotometric method and cholesterol efflux by fluorometric assay. Carotid intima-media thickness (cIMT) measurement to assess vascular health status was done using doppler. Results Rosuvastatin produced a significant decrease (p < 0.05) in lipids (total cholesterol, triglycerides, LDL-C); oxidative stress (oxLDL, oxHDL, MPO); inflammation (TNF-alpha); LCAT concentration; cIMT; significant increase in antiatherogenic HDL and cholesterol efflux (p < 0.05) and no change in apoA-I levels from baseline to 12 weeks of follow-up. A decrease in MPO activity was found to be independently associated with an increase in cholesterol efflux. Conclusions Post intervention there is a quantitative and qualitative improvement in HDL, which helps in its reverse cholesterol transport (RCT) and antioxidant functions. Improvement in HDL functions and suppression of inflammation by rosuvastatin lead to regression in cIMT, which is beneficial in decreasing the progression of cardiovascular disease (CVD) in men with diabetes.
C1 [Naresh, Sriram; Bitla, Aparna R.; Rao, P. V. L. N. Srinivasa] Sri Venkateswara Inst Med Sci, Dept Biochem, Tirupati 517507, Andhra Pradesh, India.
   [Sachan, Alok] Sri Venkateswara Inst Med Sci, Dept Endocrinol & Metab, Tirupati 517507, Andhra Pradesh, India.
   [Amancharla, Yadagiri Lakshmi] Sri Venkateswara Inst Med Sci, Dept Radiol, Tirupati 517507, Andhra Pradesh, India.
RP Bitla, AR (corresponding author), Sri Venkateswara Inst Med Sci, Dept Biochem, Tirupati 517507, Andhra Pradesh, India.
EM aparnabitla@yahoo.co.in
RI Srinivasa Rao, Prof. P/ABG-1688-2021
FU Sri Balaji Arogya Vara Prasadini Scheme of Sri Venkateswara Institute of
   Medical Sciences, Tirupati, AP, India [SBAVP-RG/Ph. D/21,
   ERPW/51-2017-18]
FX Sri Balaji Arogya Vara Prasadini Scheme [(SBAVP-RG/Ph. D/21) and
   (Faculty/ERPW/51-2017-18)] of Sri Venkateswara Institute of Medical
   Sciences, Tirupati, AP, India, provided financial support.
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NR 52
TC 7
Z9 7
U1 0
U2 5
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1355-008X
EI 1559-0100
J9 ENDOCRINE
JI Endocrine
PD JAN
PY 2021
VL 71
IS 1
BP 76
EP 86
DI 10.1007/s12020-020-02472-5
EA SEP 2020
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA PX7OZ
UT WOS:000566853500001
PM 32895874
DA 2025-06-11
ER

PT J
AU Rafie, R
   Hosseini, SA
   Hajiani, E
   Malehi, AS
   Mard, SA
AF Rafie, Roya
   Hosseini, Seyed Ahmad
   Hajiani, Eskandar
   Malehi, Amal Saki
   Mard, Seyed Ali
TI Effect of Ginger Powder Supplementation in Patients with Non-Alcoholic
   Fatty Liver Disease: A Randomized Clinical Trial
SO CLINICAL AND EXPERIMENTAL GASTROENTEROLOGY
LA English
DT Article
DE ginger; liver enzymes; non-alcoholic fatty liver disease; lipid
   profiles; insulin resistance
ID ZINGIBER-OFFICINALE; METABOLIC SYNDROME; BLOOD-SUGAR; FETUIN-A;
   STEATOHEPATITIS; ADIPONECTIN; EXPRESSION; INFLAMMATION; MECHANISMS;
   RESISTANCE
AB Background: Non-alcoholic fatty liver disease (NAFLD) is one of the most common chronic liver disorders. The main causes of NAFLD are associated with insulin resistance, severe lipid metabolism disorders, oxidative stress and inflammation. Previous studies have reported that ginger has positive metabolic results.
   Aim: The aim of this study was to determine the effect of ginger powder supplement on lipid profiles, insulin resistance, liver enzymes, inflammatory cytokines and antioxidant status in patients with NAFLD.
   Methods: In this randomized clinical trial, 46 people with NAFLD were parted into two groups and subjected to the ginger or placebo capsules (3 capsules daily, each containing 500 mg of ginger or wheat flour) over 12 weeks. All patients received a diet with balanced energy and physical activity during the intervention period. Liver ultrasonography, anthropometric indices and biochemical parameters were measured before and after intervention.
   Results: No significant difference was found between the two groups in the baseline variables at the beginning of the study. At the end of the study, serum levels of alanine aminotransferase (ALT), total cholesterol, low-density lipoprotein (LDL-C), fasting blood glucose, and insulin resistance index (HOMA), C-reactive protein (hs-CRP), and fetuin-A in the group receiving a ginger supplement significantly decreased compared to placebo. However, there was no significant difference between the two groups in body weight, fasting insulin, HDL-C, triglyceride, adiponectin, alpha-tumor necrosis factor (TNF-alpha), total antioxidant capacity (TAC), gamma-glutamyl transferase (GGT), aspartate aminotransferase (AST), fatty liver index (FLI), fatty liver grade and blood pressure.
   Conclusion: The ginger supplement may be used as a complementary therapy along with existing therapies to reduce insulin resistance, liver enzymes and inflammation in patients with non-alcoholic fatty liver.
C1 [Rafie, Roya; Hosseini, Seyed Ahmad] Ahvaz Jundishapur Univ Med Sci, Nutr & Metab Dis Res Ctr, Ahvaz, Iran.
   [Hajiani, Eskandar] Ahvaz Jundishapur Univ Med Sci, Res Ctr Infect Dis Digest Syst, Ahvaz, Iran.
   [Malehi, Amal Saki] Ahvaz Jundishapur Univ Med Sci, Hlth Res Inst, Thalassemia & Hemoglobinopathy Res Ctr, Ahvaz, Iran.
   [Mard, Seyed Ali] Ahvaz Jundishapur Univ Med Sci, Imam Khomeini Hosp, Alimentary Tract Res Ctr, Clin Res Dev Unit, Ahvaz, Iran.
C3 Ahvaz Jundishapur University of Medical Sciences (AJUMS); Ahvaz
   Jundishapur University of Medical Sciences (AJUMS); Ahvaz Jundishapur
   University of Medical Sciences (AJUMS); Ahvaz Jundishapur University of
   Medical Sciences (AJUMS)
RP Hosseini, SA (corresponding author), Ahvaz Jundishapur Univ Med Sci, Nutr & Metab Dis Res Ctr, Ahvaz, Iran.
EM Seyedahmadhosseini@yahoo.com
RI Hosseini, Ahmad/HCH-2017-2022; mard, seyyed/ABB-1797-2020; hajiani,
   eskandar/S-7352-2017; Malehi, Amal/R-8625-2017
OI Hosseini, Seyed Ahmad/0000-0002-9075-4126; Mard, Seyyed
   Ali/0000-0003-1483-8923
FU Ahvaz Jundishapur University of Medical Sciences [NRC-9501]
FX The reported results were a part of the MSc thesis of Roya Rafie
   (NRC-9501) that is registered in the Nutrition and Metabolic Diseases
   Research. This study was supported by the Vice Chancellor for research
   affairs of Ahvaz Jundishapur University of Medical Sciences.
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NR 45
TC 35
Z9 35
U1 3
U2 17
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-7023
J9 CLIN EXP GASTROENTER
JI Clin. Exp. Gastroenterol.
PY 2020
VL 13
BP 35
EP 45
DI 10.2147/CEG.S234698
PG 11
WC Gastroenterology & Hepatology
WE Emerging Sources Citation Index (ESCI)
SC Gastroenterology & Hepatology
GA KH8NV
UT WOS:000510908400001
PM 32158249
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Singh, JA
AF Singh, Jasvinder A.
TI Self-reported sleep quality and sleep disorders in people with
   physician-diagnosed gout: an Internet cross-sectional survey
SO ARTHRITIS RESEARCH & THERAPY
LA English
DT Article
DE Gout; Internet; Survey; Sleep; Sleep disorders; Sleep apnea; Quality
   improvement
ID URINARY URIC-ACID; METABOLIC SYNDROME; OXIDATIVE STRESS; CARDIOVASCULAR
   MORBIDITY; APNEA SYNDROME; INFLAMMATION; HEALTH; RISK; PRODUCTIVITY;
   DEFINITION
AB BackgroundLimited information exists regarding sleep disorders in gout. Our objective was to assess the burden of sleep disorders in people with gout.MethodsA brief anonymized Internet survey of people with physician-diagnosed gout who visited a gout education website assessed the frequency of sleep problems, sleep quality over the past 24h (0=best possible sleep, 10=worst possible sleep), daytime sleepiness on a typical day (0=none and 10=most sleepy during the day), sleep quantity (number of hours of sleep), and the frequency of snoring or gasping, and snorting or stopping breathing during the sleep, using validated questionnaires, including the NHANES 2016 sleep questionnaire. We usedChi-square test tocompare the categorical and t test the continuous variables.ResultsOf the 454 website visitors who clicked the survey, 320 survey respondents reported physician-diagnosed gout. Mean age was 57years (standard deviation [SD], 13.4), 72% were male, 77% were White, and mean gout duration was 7.6 (SD, 11). Of the respondents, 23% reported doctor-diagnosed sleep disorder (sleep apnea, 17%; sleep study ordered, diagnosis pending, 4%; other sleep disorder 2%). A mean 6.7h of sleep per night was reported (SD, 1.3). Eighty-six percent reported snoring during sleep and 45% reported having snorted, gasped, or stopped breathing while asleep. Two thirds of the patients reported feeling sleepy during the day, at least 3-4 times a month or more. Sleep quality was 5.5 (SD, 2.6), and daytime sleepiness was 3.5 (SD, 2.6) on a 0-10 scale (higher = worse).ConclusionsPeople with physician-diagnosed gout reported frequent sleep disorders and daytime sleepiness in an Internet survey. More in-depth studies are needed to better understand the association of gout with sleep disorders.
C1 [Singh, Jasvinder A.] Birmingham VA Med Ctr, Med Serv, Birmingham, W Midlands, England.
   [Singh, Jasvinder A.] Univ Alabama Birmingham, Sch Publ Hlth, Dept Epidemiol, Birmingham, AL 35294 USA.
   [Singh, Jasvinder A.] Univ Alabama Birmingham, Sch Med, Dept Med, 510 20th St S,Fac Off Tower 805B, Birmingham, AL 35294 USA.
C3 University of Alabama System; University of Alabama Birmingham;
   University of Alabama System; University of Alabama Birmingham
RP Singh, JA (corresponding author), Birmingham VA Med Ctr, Med Serv, Birmingham, W Midlands, England.; Singh, JA (corresponding author), Univ Alabama Birmingham, Sch Publ Hlth, Dept Epidemiol, Birmingham, AL 35294 USA.; Singh, JA (corresponding author), Univ Alabama Birmingham, Sch Med, Dept Med, 510 20th St S,Fac Off Tower 805B, Birmingham, AL 35294 USA.
EM Jassingh@uab.edu
RI Singh, Jasvinder/R-6172-2019; singh, jasvinder/A-6697-2009
OI singh, jasvinder/0000-0003-3485-0006
FU Division of Rheumatology at the University of Alabama at Birmingham
FX This material is the result of work supported by research funds from the
   Division of Rheumatology at the University of Alabama at Birmingham and
   the resources and use of facilities at the Birmingham VA Medical Center,
   Alabama, USA to the study PI (JAS).
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NR 39
TC 3
Z9 4
U1 2
U2 10
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1478-6354
EI 1478-6362
J9 ARTHRITIS RES THER
JI Arthritis Res. Ther.
PD JAN 25
PY 2019
VL 21
AR 36
DI 10.1186/s13075-019-1821-2
PG 7
WC Rheumatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Rheumatology
GA HI8EP
UT WOS:000456688400001
PM 30683158
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Yan, PJ
   Xu, Y
   Wan, Q
   Feng, J
   Yang, J
   Li, H
   Zhong, HH
   Gao, CL
   Zhang, ZH
AF Yan, Pijun
   Xu, Yong
   Wan, Qin
   Feng, Jian
   Yang, Jun
   Li, Hua
   Zhong, Haihua
   Gao, Chenlin
   Zhang, Zhihong
TI Impact of MPV and PDW on bone mineral density and their relationship
   with osteoporosis in Chinese patients with type 2 diabetes
SO INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
LA English
DT Article
DE Mean platelet volume; platelet distribution width; osteoporosis; bone
   mineral density; type 2 diabetes mellitus
ID MEAN PLATELET VOLUME; VIBRATION PERCEPTION THRESHOLD; AIR-FLOW
   OBSTRUCTION; PERIPHERAL NEUROPATHY; METABOLIC SYNDROME; OXIDATIVE
   STRESS; ASSOCIATION; WOMEN; ANTIOXIDANTS; PARAMETERS
AB Platelet functions are related to bone resorption and formation. This present study aimed to study the impact of mean platelet volume (MPV) and platelet distribution width (PDW) on bone mineral density (BMD) values and their relationship with the prevalence of osteoporosis in Chinese patients with type 2 diabetes mellitus (T2DM). A total of 882 elderly hospitalized T2DM patients (242 patients with osteoporosis, 323 patients with osteopenia, and 317 control subjects) undergoing BMD measurement were enrolled. Different biochemical and hematological parameters including MPV and PDW were determined, and the relationship between MPV and PDW, BMD, and osteoporosis was analyzed. There was a progressive increase in MPV and PDW levels from normal BMD subjects (11.20 +/- 1.16 fl and 14.68 +/- 2.63%, respectively) to osteopenia (11.46 +/- 1.23 fl and 15.30 +/- 2.91%, respectively) and osteoporosis (11.50 +/- 1.29 fl and 15.42 +/- 2.65%, respectively) patients (all P<0.01). Partial correlation analysis demonstrates that MPV and PDW concentrations are all negatively associated with BMD values at the lumbar spine, femoral neck, and total hip in all participants after adjustment for potential confounders (all P<0.05). Furthermore, T2DM patients in the highest quartile of MPV and PDW had significantly lower BMD values at the femoral neck and total hip, and higher prevalence of osteoporosis compared with those in the lowest MPV and PDW quartile (P<0.01 or P<0.05). Higher MPV and PDW levels were related to lower BMD values at the femoral neck and total hip and a higher prevalence of osteoporosis in T2DM patients.
C1 [Yan, Pijun; Xu, Yong; Wan, Qin; Yang, Jun; Li, Hua; Zhong, Haihua; Gao, Chenlin] South West Med Univ, Affiliated Hosp, Dept Endocrinol, Luzhou, Sichuan, Peoples R China.
   [Feng, Jian] South West Med Univ, Affiliated Hosp, Dept Cardiovasc Med, Luzhou, Sichuan, Peoples R China.
   [Zhang, Zhihong] South West Med Univ, Affiliated Hosp, Dept Gen Med, Luzhou, Sichuan, Peoples R China.
RP Zhang, ZH (corresponding author), South West Med Univ, Affiliated Hosp, Dept Gen Med, Luzhou, Sichuan, Peoples R China.
EM zhihonglily@126.com
RI Xu, Yong/AGX-9165-2022; Feng, Jian/GSM-6804-2022
FU Ministry of Science and Technology of China [2016YFC0901200, 2016
   YFC0901205]; National Natural Science Foundation of China [3130 0946];
   Health and Family Planning Commission of Sichuan Province [16129];
   Si'chuan Province Science and Technology Department [Z1448]; Luzhou
   Science and Technology Bureau [2013-S-48 (22/30)]
FX This study was supported by the grants 2016YFC0901200, 2016 YFC0901205
   from the Ministry of Science and Technology of China, research grants
   from the National Natural Science Foundation of China (3130 0946),
   Health and Family Planning Commission of Sichuan Province (16129),
   Si'chuan Province Science and Technology Department (Z1448), and Luzhou
   Science and Technology Bureau [2013-S-48 (22/30)]. The authors would
   like to thank all of the colleagues in the Clinical Laboratory Center
   and Endocrine Laboratory, and all of the nurses in our department for
   their hard work and valuable assistance with this study.
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NR 35
TC 3
Z9 3
U1 0
U2 5
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 1940-5901
J9 INT J CLIN EXP MED
JI Int. J. Clin. Exp. Med.
PY 2018
VL 11
IS 3
BP 2337
EP 2349
PG 13
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA GB4BZ
UT WOS:000429006600107
DA 2025-06-11
ER

PT J
AU Marginean, C
   Banescu, CV
   Marginean, CO
   Tripon, F
   Melit, LE
   Iancu, M
AF Marginean, Claudiu
   Banescu, Claudia Violeta
   Marginean, Cristina Oana
   Tripon, Florin
   Melit, Lorena Elena
   Iancu, Mihaela
TI Glutathione S-transferase (GSTM1, GSTT1) gene
   polymorphisms, maternal gestational weight gain, bioimpedance factors
   and their relationship with birth weight: a cross-sectional study in
   Romanian mothers and their newborns
SO ROMANIAN JOURNAL OF MORPHOLOGY AND EMBRYOLOGY
LA English
DT Article
DE mothers; newborns; GSTM1 and GSTT1 gene polymorphisms
ID ENVIRONMENTAL TOBACCO-SMOKE; BODY-COMPOSITION; METABOLIC SYNDROME; ARM
   CIRCUMFERENCE; OXIDATIVE STRESS; FTO RS9939609; MASS INDEX; OBESITY;
   ASSOCIATION; PREGNANCY
AB Introduction: The aim of this study was to assess the relationship between mother child GSTM1, GSTT1 gene polymorphisms, maternal weight gain, maternal bioimpedance parameters and newborn's weight, in order to identify the factors that influence birth weight. Patients, Materials and Methods: We performed a cross-sectional study on 405 mothers and their newborns, evaluated in an Obstetrics and Gynecology Tertiary Hospital from Romania. Results: Newborns whose mothers had the null genotype of GSTTI gene polymorphism were more likely to gain a birth weight of >3 kg, compared to newborns whose mothers had the T1 genotype (odds ratio - OR: 2.14, 95% confidence interval - CI: [1.03; 4.44]). Also, the null genotype of GSTMI gene polymorphism in both mothers and newborns was associated with a higher birth weight. Gestational weight gain was positively associated with newborn's birth weight (p<0.001). The increased mother's fat mass (%) and basal metabolism rate were also independent factors for a birth weight of more than 3 kg (p=0.006 and p=0.037). The null genotype of GSTT1 gene polymorphism in mothers and the null genotype of GSTMI in mothers and newborns had a positive effect on birth weight. Also, increased maternal fat mass and basal metabolism rate were associated with increased birth weight. Conclusions: We conclude that maternal GSTM1/GSTT1 gene polymorphisms present an impact on birth weight, being involved in the neonatal nutritional status. The clinical relevance of our study is sustained by the importance of identifying the factors that influence birth weight, which can be triggers for childhood obesity.
C1 [Marginean, Claudiu] Univ Med & Pharm Tirgu Mures, Dept Obstet & Gynecol, Targu Mures, Romania.
   [Banescu, Claudia Violeta] Univ Med & Pharm Tirgu Mures, Dept Genet, Targu Mures, Romania.
   [Marginean, Cristina Oana; Melit, Lorena Elena] Univ Med & Pharm Tirgu Mures, Dept Pediat, Targu Mures, Romania.
   [Tripon, Florin] Univ Med & Pharm Tirgu Mures, Ctr Adv Med & Pharmaceut Res, Targu Mures, Romania.
   [Iancu, Mihaela] Iuliu Hatieganu Univ Med & Pharm, Dept Med Informat & Biostat, Cluj Napoca, Romania.
C3 George Emil Palade University of Medicine, Pharmacy, Science, &
   Technology of Targu Mures; George Emil Palade University of Medicine,
   Pharmacy, Science, & Technology of Targu Mures; George Emil Palade
   University of Medicine, Pharmacy, Science, & Technology of Targu Mures;
   George Emil Palade University of Medicine, Pharmacy, Science, &
   Technology of Targu Mures; Iuliu Hatieganu University of Medicine &
   Pharmacy
RP Banescu, CV (corresponding author), Univ Med & Pharm Tirgu Mures, Ctr Adv Med & Pharmaceut Res, Genet Lab, 38 Gheorghe Marinescu St, Targu Mures 540139, Romania.
EM claudia.banescu@umftgm.ro
RI Melit, Lorena Elena/AAE-6650-2022; Iancu, Mihaela/HII-4338-2022;
   Marginean, Claudiu/AAR-5176-2021; Marginean, Cristina
   Oana/AAR-5227-2021; Banescu, Claudia/C-6599-2012; Tripon,
   Florin/C-7791-2017
OI Banescu, Claudia/0000-0002-3235-524X; Tripon,
   Florin/0000-0002-4297-9988; Iancu, Mihaela/0000-0002-4557-5364
FU University of Medicine and Pharmacy of Tirgu Mures, Romania
   [275/4/11.01.2017]
FX This research was partially supported by the Collective Research Grants
   of the University of Medicine and Pharmacy of Tirgu Mures, Romania ("The
   role of mother's genetic determinism in child's obesity correlated with
   bioimpedance and anthropometric parameters" No. 275/4/11.01.2017).
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NR 62
TC 13
Z9 14
U1 0
U2 3
PU EDITURA ACAD ROMANE
PI BUCURESTI
PA CALEA 13 SEPTEMBRIE NR 13, SECTOR 5, BUCURESTI 050711, ROMANIA
SN 1220-0522
J9 ROM J MORPHOL EMBRYO
JI Rom. J. Morphol. Embryol.
PY 2017
VL 58
IS 4
BP 1285
EP 1293
PG 9
WC Developmental Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Developmental Biology
GA GA9KO
UT WOS:000428660300018
PM 29556619
DA 2025-06-11
ER

PT J
AU Yokoi, Y
   Kondo, T
   Okumura, N
   Shimokata, K
   Osugi, S
   Maeda, K
   Murohara, T
AF Yokoi, Yuki
   Kondo, Takahisa
   Okumura, Naoki
   Shimokata, Keiko
   Osugi, Shigeki
   Maeda, Kengo
   Murohara, Toyoaki
TI Serum uric acid as a predictor of future hypertension: Stratified
   analysis based on body mass index and age
SO PREVENTIVE MEDICINE
LA English
DT Article
DE Blood pressure; Epidemiology; Hypertension; Uric acid
ID MUSCLE-CELL PROLIFERATION; BLOOD-PRESSURE; INCIDENT HYPERTENSION;
   METABOLIC SYNDROME; OXIDATIVE STRESS; CARDIOVASCULAR-DISEASE;
   INDEPENDENT MECHANISM; URATE TRANSPORTER; KIDNEY-DISEASE; JAPANESE MEN
AB Background. Serum uric acid level is a predictor of future hypertension. However, its dependence on body mass index or age is unclear.
   Methods. We examined 26,442 Japanese males aged 18-60 years free from hypertension or diagnosed cardiovascular disease at baseline followed up between 2000 and 2010. Participants were categorized into three groups according to the tertile of serum uric acid levels [mg/dL; 1st (reference): 0.1-5.3; 2nd: 5.4-6.2; 3rd: 6.3-11.6]. Incident hypertension was defined as newly detected blood pressure >= 140/90 mm Hg and/or antihypertensive drugs initiation. Body mass index (<25 kg/m(2) vs. >= 25 kg/m(2)) and age (<40 years vs. >= 40 years) were stratified into two groups.
   Results. During a mean follow-up of 7.2 years, there were 11,361 (43%) hypertension cases. Mean serum uric acid levels (mg/dL) at baseline in each group were 1st tertile, 4.6; 2nd tertile, 5.8; and 3rd tertile, 7.0. The cumulative incident hypertension rate was significantly higher in the 3rd tertile (50.8%) than in the 1st (37.4%). Multiple-adjusted hazard ratios (95% confidence interval) for incident hypertension compared with 1st tertile were 1.01 (0.96-1.05) and 1.15 (1.10-1.21) in the 2nd and 3rd tertile, respectively. There was a significant interaction between age and serumuric acid level (p for interaction=0.035). In subjects aged >= 40 years, the 3rd serumuric acid group showed higher hazard ratios [1.48 (1.38-1.59)].
   Conclusion. High serum uric acid level was associated with future hypertension in young and middle-aged Japanese males. This association was stronger among subjects >= 40 years old. (C) 2016 The Authors. Published by Elsevier Inc.
C1 [Yokoi, Yuki; Okumura, Naoki; Shimokata, Keiko; Osugi, Shigeki; Maeda, Kengo; Murohara, Toyoaki] Nagoya Univ, Grad Sch Med, Dept Cardiol, Nagoya, Aichi, Japan.
   [Kondo, Takahisa] Nagoya Univ, Grad Sch Med, Dept Adv Med Cardiopulm Dis, Nagoya, Aichi, Japan.
C3 Nagoya University; Nagoya University
RP Kondo, T (corresponding author), Nagoya Univ, Grad Sch Med, Dept Adv Med Cardiopulm Dis, Showa Ku, 65 Tsurumai Cho, Nagoya, Aichi, Japan.
EM takahisa@med.nagoya-u.ac.jp
RI Murohara, Toyoaki/M-4958-2014
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NR 39
TC 29
Z9 32
U1 0
U2 7
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0091-7435
EI 1096-0260
J9 PREV MED
JI Prev. Med.
PD SEP
PY 2016
VL 90
BP 201
EP 206
DI 10.1016/j.ypmed.2016.07.007
PG 6
WC Public, Environmental & Occupational Health; Medicine, General &
   Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health; General & Internal Medicine
GA EC7KU
UT WOS:000388318000028
PM 27404578
OA hybrid
DA 2025-06-11
ER

PT J
AU Puhkala, J
   Luoto, R
   Ahotupa, M
   Raitanen, J
   Vasankari, T
AF Puhkala, Jatta
   Luoto, Riitta
   Ahotupa, Markku
   Raitanen, Jani
   Vasankari, Tommi
TI Postpartum Weight Retention is Associated with Elevated Ratio of
   Oxidized LDL Lipids to HDL-Cholesterol
SO LIPIDS
LA English
DT Article
DE Oxidized LDL to HDL ratio; Postpartum; Plasma lipids; Weight retention;
   Weight loss
ID LOW-DENSITY-LIPOPROTEIN; CORONARY-ARTERY-DISEASE; LINE DIENE
   CONJUGATION; IN-VIVO; OXIDATIVE STRESS; RISK-FACTOR; WOMEN; MEN;
   POPULATION; REDUCTION
AB Oxidized LDL lipids (ox-LDL) are associated with lifestyle diseases such as cardiovascular diseases, metabolic syndrome and type 2 diabetes. The present study investigated how postpartum weight retention effects on ox-LDL and serum lipids. The study is a nested comparative research of a cluster-randomized controlled trial, NELLI (lifestyle and counselling during pregnancy). During early pregnancy (8-12 weeks) and 1 year postpartum, 141 women participated in measurements for determining of plasma lipids: total cholesterol (T-C), LDL-cholesterol (LDL-C), HDL-cholesterol (HDL-C), triacylglycerols (TAG) and ox-LDL. Subjects were stratified into tertiles (weight loss, unaltered weight and weight gain groups) based on their weight change from baseline to follow-up. Ox-LDL was determined by baseline level of conjugated dienes in LDL lipids. Among the group of weight gainers, concentration of TAG reduced less (-0.14 vs. -0.33, p = 0.002), HDL-C reduced more (-0.31 vs. -0.16, p = 0.003) and ox-LDL/HDL-C ratio increased (3.0 vs. -0.2, p = 0.003) when compared to group of weight loss. Both T-C and LDL-C elevated more (0.14 vs. -0.21, p = 0.008; 0.31 vs. 0.07, p = 0.015) and TAG and ox-LDL reduced less (-0.33 vs. 0.20, p = 0.033; -3.33 vs. -0.68, p = 0.026) in unaltered weight group compared to weight loss group. The women who gained weight developed higher TAG and ox-LDL/HDL-C ratio as compared to those who lost weight. Postpartum weight retention of 3.4 kg or more is associated with atherogenic lipid profile.
C1 [Puhkala, Jatta; Luoto, Riitta; Raitanen, Jani; Vasankari, Tommi] UKK Inst Hlth Promot Res, Tampere 33501, Finland.
   [Luoto, Riitta; Vasankari, Tommi] Natl Inst Hlth & Welf, Helsinki, Finland.
   [Ahotupa, Markku] Univ Turku, Dept Physiol, Turku, Finland.
   [Raitanen, Jani] Univ Tampere, Sch Hlth Sci, FIN-33101 Tampere, Finland.
C3 UKK Institute; Finland National Institute for Health & Welfare;
   University of Turku; Tampere University
RP Puhkala, J (corresponding author), UKK Inst Hlth Promot Res, Box 30, Tampere 33501, Finland.
EM jatta.puhkala@uta.fi
RI Raitanen, Jani/AAW-9233-2021
OI Raitanen, Jani/0000-0001-7674-0978
FU Tampere University Hospital; Juho Vainio Foundation; Academy of Finland;
   Ministry of Education and Culture; Ministry of Social Affairs and Health
FX This study was funded by Competitive Research Funding of the Tampere
   University Hospital, Juho Vainio Foundation, Academy of Finland,
   Ministry of Education and Culture, and Ministry of Social Affairs and
   Health. We are thankful to Tiina Solakivi, PhD, associate professor at
   the Medical School at the University of Tampere, who was responsible for
   the laboratory testing.
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NR 43
TC 21
Z9 22
U1 0
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0024-4201
EI 1558-9307
J9 LIPIDS
JI Lipids
PD DEC
PY 2013
VL 48
IS 12
BP 1227
EP 1235
DI 10.1007/s11745-013-3852-9
PG 9
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA 257TA
UT WOS:000327408300006
PM 24122103
DA 2025-06-11
ER

PT J
AU Jaitovich, A
   Bertorello, AM
AF Jaitovich, Ariel
   Bertorello, Alejandro M.
TI Intracellular sodium sensing: SIK1 network, hormone action and high
   blood pressure
SO BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
LA English
DT Review
DE Na+; K+-ATPase; High blood pressure; Dopamine; Angiotensin II;
   Aldosterone; Adducin; Salt-inducible kinase; Gene regulation
ID HYPERTENSION-LINKED MUTATION; NA+,K+-ATPASE ALPHA-SUBUNIT; PROTEIN
   PHOSPHATASE 2A; CREB COACTIVATOR TORC2; HIGH-SALT DIET; NA-K-ATPASE;
   PLASMA-MEMBRANE; GENE-EXPRESSION; ANGIOTENSIN-II; MEDICAL PROGRESS
AB Sodium is the main determinant of body fluid distribution. Sodium accumulation causes water retention and, often, high blood pressure. At the cellular level, the concentration and active transport of sodium is handled by the enzyme Na+,K+-ATPase, whose appearance enabled evolving primitive cells to cope with osmotic stress and contributed to the complexity of mammalian organisms. Na+,K+-ATPase is a platform at the hub of many cellular signaling pathways related to sensing intracellular sodium and dealing with its detrimental excess. One of these pathways relies on an intracellular sodium-sensor network with the salt-inducible kinase 1 (SIK1) at its core. When intracellular sodium levels rise, and after the activation of calcium-related signals, this network activates the Na+,K+-ATPase and expel the excess of sodium from the cytosol. The SIK1 network also mediates sodium-independent signals that modulate the activity of the Na+,K+-ATPase, like dopamine and angiotensin, which are relevant per se in the development of high blood pressure. Animal models of high blood pressure, with identified mutations in components of multiple pathways, also have alterations in the SIK1 network. The introduction of some of these mutants into normal cells causes changes in SIK1 activity as well. Some cellular processes related to the metabolic syndrome, such as insulin effects on the kidney and other tissues, also appear to involve the SIK1. Therefore, it is likely that this protein, by modulating active sodium transport and numerous hormonal responses, represents a "crossroad" in the development and adaptation to high blood pressure and associated diseases. (c) 2010 Elsevier B.V. All rights reserved.
C1 [Jaitovich, Ariel; Bertorello, Alejandro M.] Karolinska Univ Hosp Solna, Karolinska Inst, Dept Med, Membrane Signaling Networks,Atherosclerosis Res U, Stockholm 17176, Sweden.
C3 Karolinska Institutet; Karolinska University Hospital
RP Bertorello, AM (corresponding author), Karolinska Univ Hosp Solna, Karolinska Inst, Dept Med, Membrane Signaling Networks,Atherosclerosis Res U, Stockholm 17176, Sweden.
EM ajaitovich@ccbhs.org; alejandro.bertorello@ki.se
FU Cook County Bureau of Health Services, Illinois; Swedish Heart and Lung
   Foundation; Swedish Research Council
FX Dr A. Jaitovich is funded by the Cook County Bureau of Health Services,
   Illinois, and Dr A.M. Bertorello by a Senior Research Fellowship from
   the Swedish Heart and Lung Foundation. We thank all members of Membrane
   Signaling Networks and Professor H. Takemori for their input and
   contributions to this article. The Swedish Research Council and the
   Swedish Heart and Lung Foundation funded Dr Bertorello's work.
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NR 113
TC 43
Z9 53
U1 1
U2 10
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0925-4439
EI 1879-260X
J9 BBA-MOL BASIS DIS
JI Biochim. Biophys. Acta-Mol. Basis Dis.
PD DEC
PY 2010
VL 1802
IS 12
SI SI
BP 1140
EP 1149
DI 10.1016/j.bbadis.2010.03.009
PG 10
WC Biochemistry & Molecular Biology; Biophysics; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Cell Biology
GA 682HW
UT WOS:000284393000003
PM 20347966
OA Bronze
DA 2025-06-11
ER

PT J
AU Wu, JHY
   Hodgson, JM
   Clarke, MW
   Indrawan, AP
   Barden, AE
   Puddey, IB
   Croft, KD
AF Wu, Jason H. Y.
   Hodgson, Jonathan M.
   Clarke, Michael W.
   Indrawan, Adeline P.
   Barden, Anne E.
   Puddey, Ian B.
   Croft, Kevin D.
TI Inhibition of 20-Hydroxyeicosatetraenoic Acid Synthesis Using Specific
   Plant Lignans In Vitro and Human Studies
SO HYPERTENSION
LA English
DT Article
DE 20-HETE; cytochrome P450; sesame; vitamin E; cardiovascular disease
ID BLOOD-PRESSURE; OXIDATIVE STRESS; GAMMA-TOCOPHEROL; ARACHIDONIC-ACID;
   METABOLIC SYNDROME; 20-HETE EXCRETION; URINARY 20-HETE; ISCHEMIC-STROKE;
   SESAME SEED; LLU-ALPHA
AB Sesamin, the major lignan found in sesame, has been shown to increase vitamin E levels by inhibiting its metabolism via the cytochrome P-450 isozyme CYP4F2. CYP4F2 and CYP4A11 are the predominant human isoforms that synthesize 20-hydroxyeicosatetraenoic acid (20-HETE) from arachidonic acid. Considerable evidence suggests that 20-HETE may play a role in the pathogenesis of hypertension. We hypothesized that sesamin could be an inhibitor of 20-HETE synthesis. This study investigated the effects of sesamin on 20-HETE synthesis in vitro and the effect of sesame supplementation on plasma and urinary 20-HETE concentrations in humans. Human microsomes were used to investigate the potency and selectivity of sesamin inhibition of 20-HETE synthesis. Sesamin inhibited human renal and liver microsome 20-HETE synthesis with IC50 <20 mu mol/L. It was selective toward CYP4F2 (IC50: 1.9 mu mol/L) and had reduced activity toward CYP4A11 (IC50: >150 mu mol/L), as well as cytochrome P epoxygenation of arachidonic acid (IC50: >50 mu mol/L). In a randomized, controlled crossover trial, overweight men and women (n = 33) consumed 25 g/d of sesame (approximate to 50 mg/d of sesame lignan) or an isocaloric matched control for 5 weeks each. Relative to control, sesame supplementation resulted in a 28% decrease in plasma and a 32% decrease in urinary 20-HETE (P<0.001). Urinary sodium, potassium, and blood pressure were not affected. This study demonstrates for the first time that sesame supplementation in humans reduces the plasma and urinary levels of 20-HETE, likely via inhibition of CYP4F2 by sesame lignans. These results suggest that sesame lignans could be used for the investigation of potential roles of 20-HETE in humans. (Hypertension. 2009;54:1151-1158.)
C1 [Wu, Jason H. Y.; Hodgson, Jonathan M.; Indrawan, Adeline P.; Barden, Anne E.; Puddey, Ian B.; Croft, Kevin D.] Univ Western Australia, Sch Med & Pharmacol, Royal Perth Hosp, Perth, WA 6847, Australia.
   [Clarke, Michael W.] Univ Western Australia, Dept Core Clin Pathol & Biochem, Royal Perth Hosp, Perth, WA 6847, Australia.
C3 East Metropolitan Health Service; Royal Perth Hospital; University of
   Western Australia; University of Western Australia; East Metropolitan
   Health Service; Royal Perth Hospital
RP Wu, JHY (corresponding author), Univ Western Australia, Sch Med & Pharmacol, POB X2213 GPO, Perth, WA 6847, Australia.
EM jwu@meddent.uwa.edu.au
RI Croft, Kevin/C-4675-2013; Hodgson, Jonathan/C-3900-2008; Wu,
   Jason/J-2936-2019; Puddey, Ian/H-5673-2014; Clarke, Michael/H-8997-2014
OI Hodgson, Jonathan/0000-0001-6184-7764; Wu, Jason/0000-0003-2073-3562;
   Croft, Kevin/0000-0003-1596-4913; Barden, Anne/0000-0001-7631-0767;
   Clarke, Michael/0000-0002-9639-5670
FU National Health and Medical Research Council of Australia [403957];
   Royal Perth Hospital Medical Research Foundation; University of Western
   Australia Faculty of Medicine, Dentistry, and Health Sciences
FX This study was funded by the National Health and Medical Research
   Council of Australia (project grant 403957) and a Royal Perth Hospital
   Medical Research Foundation Research Grant. J. H. Y. W. acknowledges the
   assistance of a University of Western Australia Faculty of Medicine,
   Dentistry, and Health Sciences Fellowship.
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NR 39
TC 31
Z9 37
U1 0
U2 7
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0194-911X
EI 1524-4563
J9 HYPERTENSION
JI Hypertension
PD NOV
PY 2009
VL 54
IS 5
BP 1151
EP U350
DI 10.1161/HYPERTENSIONAHA.109.139352
PG 10
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 509CW
UT WOS:000270992100036
PM 19786646
OA Bronze
DA 2025-06-11
ER

PT J
AU Li, L
   Tian, XC
   Gao, YR
   Gu, YS
   Zhang, KH
   Li, LT
   Wang, HB
   He, WL
AF Li, Lin
   Tian, Xiaochao
   Gao, Yaran
   Gu, Yongsheng
   Zhang, Kaihua
   Li, Litao
   Wang, Hebo
   He, Weiliang
TI Serum uric acid predicts the development of atherosclerosis in women but
   not in men: A ten-year cohort study in China
SO NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
LA English
DT Article
DE Serum uric acid; Atherosclerosis; Carotid plaque; A ten-year cohort
   study
ID SUBCLINICAL ATHEROSCLEROSIS; METABOLIC SYNDROME; HYPERTENSION; DISEASE;
   HYPERURICEMIA; INFLAMMATION; ASSOCIATION; DEFINITION; PROGNOSIS; STRESS
AB Background and aim: Atherosclerosis is becoming a significant health burden. Serum uric acid (SUA) is the final enzymatic product of purine metabolism and can contribute to the development of atherosclerosis. The aim of this study was to explore the possible predictive value of SUA in the development of atherosclerosis in a healthy Chinese population. Methods and results: In this study, a total of 11,222 healthy subjects with no carotid plaque at baseline were enrolled and divided into sex-specific groups, and then the occurrence of carotid plaque during the follow-up time was documented. The association between carotid plaque and SUA levels was examined using Cox proportional-hazards regression models. The mean SUA level was 5.35 +/- 1.41 mg/dL. A total of 2,911 individuals (25.94%) developed carotid plaque during the follow-up time, including 1,071 females and 1,840 males. After adjusting for potential confounding factors, the hazard ratio (HR) and 95% confidence interval (95% CI) in women for the occurrence of carotid plaque associated with SUA levels were 1.163 (1.017-1.330), but no significant correlation was found in men, as the HR was 1.050 (0.965-1.143). Conclusion: Our results indicate that SUA levels predict the development of carotid plaque independent of traditional risk factors only in women. 2023 The Author(s). Published by Elsevier B.V. on behalf of The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
C1 [Li, Lin; Gao, Yaran; Gu, Yongsheng; Zhang, Kaihua; Li, Litao; Wang, Hebo] Hebei Gen Hosp, Dept Neurol, Shijiazhuang, Hebei, Peoples R China.
   [Tian, Xiaochao; Gao, Yaran; Gu, Yongsheng; Zhang, Kaihua; Li, Litao; Wang, Hebo] Hebei Key Lab Cerebral Network & Cognit Disorders, Shijiazhuang, Hebei, Peoples R China.
   [Tian, Xiaochao] Hebei Med Univ, Hosp 2, Dept Cardiol, Shijiazhuang, Peoples R China.
   [He, Weiliang] Heyuan Peoples Hosp, Guangdong Prov Peoples Hosp Heyuan Hosp, Dept Neurol, Heyuan, Peoples R China.
   [He, Weiliang] Heyuan Peoples Hosp, Heyuan Key Lab Mol Diag & Dis Prevent & Treatment, Doctors Stn Guangdong Prov, Heyuan 517000, Guangdong, Peoples R China.
   [Wang, Hebo] Hebei Gen Hosp, Dept Neurol, 348 21 Heping West Rd, Shijiazhuang 050051, Peoples R China.
   [He, Weiliang] Heyuan Peoples Hosp, Guangdong Prov Peoples Hosp, Dept Neurol, 733 Wenxiang Rd, Heyuan 517000, Peoples R China.
C3 Hebei Medical University; Guangdong Academy of Medical Sciences &
   Guangdong General Hospital
RP Wang, HB (corresponding author), Hebei Gen Hosp, Dept Neurol, 348 21 Heping West Rd, Shijiazhuang 050051, Peoples R China.; He, WL (corresponding author), Heyuan Peoples Hosp, Guangdong Prov Peoples Hosp, Dept Neurol, 733 Wenxiang Rd, Heyuan 517000, Peoples R China.
EM wanghbhope@hebmu.edu.cn; wanghbhope@hebmu.edu.cn
RI Wang, Hebo/S-4285-2019
OI Wang, Hebo/0000-0002-0598-5772
FU Scientific research start-up funds of Heyuan People's Hospital
   [HFQDJF-202301]; High-level Talent Foundation of Hebei Province
   [A202002004]; Natural Science Foundation of Hebei Province
   [H2020307041]; Central Government Guides Local Funds for Science and
   Technology Development [236Z7745G]
FX This work was supported by grants from the scientific research start-up
   funds of Heyuan People's Hospital(HFQDJF-202301), the High-level Talent
   Foundation of Hebei Province in 2021 (No. A202002004), the Natural
   Science Foundation of Hebei Province (No. H2020307041) and Central
   Government Guides Local Funds for Science and Technology Development
   (NO. 236Z7745G). The funding institutions did not have any role in the
   design of the study, collection and analysis of the data, writing of the
   manuscript, or decision to publish.
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NR 40
TC 2
Z9 2
U1 2
U2 7
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 0939-4753
EI 1590-3729
J9 NUTR METAB CARDIOVAS
JI Nutr. Metab. Carbiovasc. Dis.
PD JAN
PY 2024
VL 34
IS 1
BP 198
EP 205
DI 10.1016/j.numecd.2023.10.005
EA DEC 2023
PG 8
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism; Nutrition
   & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism;
   Nutrition & Dietetics
GA FN0K8
UT WOS:001146386600001
PM 38057200
OA hybrid
DA 2025-06-11
ER

PT J
AU Hu, YX
   Zhang, ZQ
   Zhou, QJ
   Liao, JY
   Chai, XL
AF Hu, Yu-Xin
   Zhang, Zhi-Qing
   Zhou, Qin-Jie
   Liao, Jun-Ya
   Chai, Xin-Lou
TI Mechanism exploration of the classical traditional chinese medicine
   formula huoluo xiaoling pill in clinical treatment and the traditional
   chinese medicine theory "treating different diseases with the same
   method": A network pharmacology study and molecular docking verification
SO WORLD JOURNAL OF TRADITIONAL CHINESE MEDICINE
LA English
DT Article
DE Huoluo Xiaoling Pill; molecular docking; network pharmacology;
   traditional chinese medicine; treating different diseases with the same
   method
AB Objective: To analyze the possible mechanism of the Huoluo Xiaoling Pill in the treatment of three diseases, hyperglycemia, hyperlipidemia, and metabolic syndrome, and to provide ideas for learning the mechanism of "Treating different diseases with the same method " in Traditional Chinese Medicine (TCM) theory. Materials and Methods: The Traditional Chinese Medicine System Pharmacology Database and UniProt databases were used to screen the main ingredients and targets of the Huoluo Xiaoling Pill. The GeneCards database was used to screen the targets of the diseases, and Cytoscape 3.7.2 was used to construct a "Drug-Components-Targets-Disease " network to determine the core components. The STRING database was used to construct the protein-protein-interaction network, and gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomics enrichment analyses were carried out on the Metascape database. AutoDock 1.5.6 was used for molecular docking. Results: A total of 118 active components and 208 targets were screened in the Huoluo Xiaoling Pill. Quercetin, tanshinone IIA, luteolin, and ellagic acid were potential core components of Huoluo Xiaoling Pill treating the three diseases, and interleukin 6, Tumor necrosis factor, and vascular endothelial growth factor were potential key targets. Co-occurring GO biological processes involved responses to the molecules of bacterial origin, and the AGE-RAGE signaling, fluid shear stress, and atherosclerosis pathways were the co-occurring pathways. Molecular docking revealed good docking conditions between screened targets and components. Conclusion: This study predicted the mechanism of the Huoluo Xiaoling Pill in treating the three diseases. At the same time, the co-occurring targets and pathways between the three diseases provided a material basis for the TCM theory, "Treating different diseases with the same method. "
C1 [Hu, Yu-Xin; Zhang, Zhi-Qing; Zhou, Qin-Jie; Liao, Jun-Ya; Chai, Xin-Lou] Beijing Univ Chinese Med, Sch Chinese Med, Beijing, Peoples R China.
C3 Beijing University of Chinese Medicine
RP Chai, XL (corresponding author), Beijing Univ Chinese Med, Sch Chinese Med, Beijing, Peoples R China.
EM mmxin3@126.com
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NR 21
TC 6
Z9 6
U1 1
U2 17
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, Maharashtra, INDIA
SN 2311-8571
EI 2589-2894
J9 WORLD J TRAD CHINESE
JI World J. Trad. Chinese Med.
PD JAN-MAR
PY 2022
VL 8
IS 1
BP 131
EP 140
DI 10.4103/wjtcm.wjtcm_58_21
PG 10
WC Integrative & Complementary Medicine; Medicine, Research & Experimental;
   Pharmacology & Pharmacy
WE Emerging Sources Citation Index (ESCI)
SC Integrative & Complementary Medicine; Research & Experimental Medicine;
   Pharmacology & Pharmacy
GA YR5BL
UT WOS:000750006500012
OA gold
DA 2025-06-11
ER

PT J
AU van der Valk, E
   Abawi, O
   Mohseni, M
   Abdelmoumen, A
   Wester, V
   van der Voorn, B
   Iyer, A
   van den Akker, E
   Hoeks, S
   van den Berg, S
   de Rijke, Y
   Stalder, T
   van Rossum, E
AF van der Valk, Eline
   Abawi, Ozair
   Mohseni, Mostafa
   Abdelmoumen, Amir
   Wester, Vincent
   van der Voorn, Bibian
   Iyer, Anand
   van den Akker, Erica
   Hoeks, Sanne
   van den Berg, Sjoerd
   de Rijke, Yolanda
   Stalder, Tobias
   van Rossum, Elisabeth
TI Cross-sectional relation of long-term glucocorticoids in hair with
   anthropometric measurements and their possible determinants: A
   systematic review and meta-analysis
SO OBESITY REVIEWS
LA English
DT Review
DE adiposity; hair glucocorticoids; meta-analysis; systematic review
ID BODY-MASS INDEX; CORTISOL CONCENTRATIONS; SCALP HAIR; CHRONIC STRESS;
   COGNITIVE PERFORMANCE; METABOLIC SYNDROME; HPA AXIS; ASSOCIATION;
   HEALTHY; CHILDREN
AB Background Long-term glucocorticoids (HairGC) measured in scalp hair have been associated with body mass index (BMI), waist circumference (WC), and waist-hip-ratio (WHR) in several cross-sectional studies. We aimed to investigate the magnitude, strength, and clinical relevance of these relations across all ages. Methods We performed a systematic review and meta-analysis (PROSPERO registration CRD42020205187) searching for articles relating HairGC to measures of obesity. Main outcomes were bivariate correlation coefficients and unadjusted simple linear regression coefficients relating hair cortisol (HairF) and hair cortisone (HairE) to BMI, WC, and WHR. Results We included k = 146 cohorts (n = 34,342 individuals). HairGC were positively related to all anthropometric measurements. The strongest correlation and largest effect size were seen for HairE-WC: pooled correlation 0.18 (95%CI 0.11-0.24; k = 7; n = 3,158; I-2 = 45.7%) and pooled regression coefficient 11.0 cm increase in WC per point increase in 10-log-transformed HairE (pg/mg) on liquid-chromatography-(tandem) mass spectrometry (LC-MS) (95%CI 10.1-11.9 cm; k = 6; n = 3,102). Pooled correlation for HairF-BMI was 0.10 (95%CI 0.08-0.13; k = 122; n = 26,527; I-2 = 51.2%) and pooled regression coefficient 0.049 kg/m(2) per point increase in 10-log-transformed HairF (pg/mg) on LC-MS (95%CI 0.045-0.054 kg/m(2); k = 26; n = 11,635). Discussion There is a consistent positive association between HairGC and BMI, WC, and WHR, most prominently and clinically relevant for HairE-WC. These findings overall suggest an altered setpoint of the hypothalamic-pituitary-adrenal axis with increasing central adiposity.
C1 [van der Valk, Eline; Mohseni, Mostafa; Abdelmoumen, Amir; Wester, Vincent; van der Voorn, Bibian; Iyer, Anand; van den Berg, Sjoerd; van Rossum, Elisabeth] Erasmus MC, Univ Med Ctr Rotterdam, Dept Internal Med, Div Endocrinol, Rotterdam, Netherlands.
   [van der Valk, Eline; Abawi, Ozair; Mohseni, Mostafa; Abdelmoumen, Amir; Wester, Vincent; van der Voorn, Bibian; Iyer, Anand; van den Akker, Erica; van Rossum, Elisabeth] Erasmus MC, Univ Med Ctr Rotterdam, Obes Ctr CGG, Rotterdam, Netherlands.
   [Abawi, Ozair; van der Voorn, Bibian; van den Akker, Erica] Erasmus MC, Univ Med Ctr Rotterdam, Sophia Childrens Hosp, Dept Pediat,Div Endocrinol, Rotterdam, Netherlands.
   [Hoeks, Sanne] Erasmus MC, Dept Anesthesiol, Rotterdam, Netherlands.
   [van den Berg, Sjoerd; de Rijke, Yolanda] Erasmus MC, Univ Med Ctr Rotterdam, Dept Clin Chem, Rotterdam, Netherlands.
   [Stalder, Tobias] Univ Siegen, Dept Clin Psychol, Siegen, Germany.
C3 Erasmus University Rotterdam; Erasmus MC; Erasmus University Rotterdam;
   Erasmus MC; Erasmus University Rotterdam; Erasmus MC; Erasmus MC -
   Sophia Children's Hospital; Erasmus University Rotterdam; Erasmus MC;
   Erasmus University Rotterdam; Erasmus MC; Universitat Siegen
RP van Rossum, E (corresponding author), Erasmus MC, Univ Med Ctr Rotterdam, Dept Internal Med, Room Rg 5 POB 2400, NL-3000 CA Rotterdam, Netherlands.; van Rossum, E (corresponding author), Erasmus MC, Univ Med Ctr Rotterdam, Obes Ctr CGG Ctr Gezond Gewicht, Room Rg 5 POB 2400, NL-3000 CA Rotterdam, Netherlands.
EM e.vanrossum@erasmusmc.nl
RI de Rijke, Yolanda/HLP-5779-2023; van Rossum, Elisabeth/AAP-9388-2020;
   Hoeks, Sanne/AAM-3313-2020; van der Voorn, Bibian/ABB-3751-2021
OI Abawi, Ozair/0000-0002-1343-6562; Iyer, Anand/0000-0001-6821-1048;
   Abdelmoumen, Amir/0000-0002-3871-9147; Mohseni,
   Mostafa/0000-0003-0021-5477; van den Berg, Sjoerd/0000-0001-5937-7505;
   van Rossum, Elisabeth/0000-0003-0120-4913; van der Voorn,
   Bibian/0000-0003-1299-0067; van der Valk, Eline/0000-0001-5134-5453; van
   den Akker, Erica/0000-0001-5352-9328; Stalder,
   Tobias/0000-0001-7558-1274; Hoeks, Sanne/0000-0003-4022-9574
FU Elisabeth Foundation; Netherlands Organization of Scientific Research
   NWO; ZonMW Vidi [91716453]
FX Elisabeth Foundation, a non-profit organization supporting academic
   obesity research; Netherlands Organization of Scientific Research NWO;
   ZonMW Vidi, Grant/Award Number: 91716453
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NR 158
TC 20
Z9 21
U1 0
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1467-7881
EI 1467-789X
J9 OBES REV
JI Obes. Rev.
PD MAR
PY 2022
VL 23
IS 3
AR e13376
DI 10.1111/obr.13376
EA NOV 2021
PG 21
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism
GA YS0YT
UT WOS:000721484800001
PM 34811866
OA Green Published
DA 2025-06-11
ER

PT J
AU Härkänen, T
   Kuulasmaa, K
   Sares-Jäske, L
   Jousilahti, P
   Peltonen, M
   Borodulin, K
   Knekt, P
   Koskinen, S
AF Harkanen, Tommi
   Kuulasmaa, Kari
   Sares-Jaske, Laura
   Jousilahti, Pekka
   Peltonen, Markku
   Borodulin, Katja
   Knekt, Paul
   Koskinen, Seppo
TI Estimating expected life-years and risk factor associations with
   mortality in Finland: cohort study
SO BMJ OPEN
LA English
DT Article
ID ALL-CAUSE MORTALITY; CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME;
   PHYSICAL-ACTIVITY; SATISFACTION; METAANALYSIS; EDUCATION; TESTS
AB Objective To develop a tool to inform individuals and general practitioners about benefits of lifestyle changes by providing estimates of the expected age of death (EAD) for different risk factor values, and for those who plan and decide on preventive activities and health services at population level, to calculate potential need for these.
   Design Prospective cohort study to estimate EAD using a model with 27 established risk factors, categorised into four groups: (1) sociodemographic background and medical history, (2) lifestyles, (3) life satisfaction, and (4) biological risk factors. We apply a Poisson regression model on the survival data split into 1-year intervals.
   Participants Total of 38 549 participants aged 25-74 years at baseline of the National FINRISK Study between 1987 and 2007.
   Primary outcome measures Register-based comprehensive mortality data from 1987 to 2014 with an average follow-up time of 16 years and 4310 deaths.
   Results Almost all risk factors included in the model were statistically significantly associated with death. The largest influence on the EAD appeared to be a current heavy smoker versus a never smoker as the EAD for a 30-year-old man decreased from 86.8 years, which corresponds to the reference values of the risk factors, to 80.2 years. Diabetes decreased EAD by >6.6 years. Whole or full milk consumers had 3.4 years lower EAD compared with those consuming skimmed milk. Physically inactive men had 2.4 years lower EAD than those with high activity. Men who found their life almost unbearable due to stress had 2.8 years lower EAD.
   Conclusions The biological risk factors and lifestyles, and the factors connected with life satisfaction were clearly associated with EAD. Our model for estimating a person's EAD can be used to motivate lifestyle changes.
C1 [Harkanen, Tommi; Kuulasmaa, Kari; Sares-Jaske, Laura; Jousilahti, Pekka; Peltonen, Markku; Borodulin, Katja; Knekt, Paul; Koskinen, Seppo] Finnish Inst Hlth & Welf, Publ Hlth Solut, Helsinki, Finland.
   [Borodulin, Katja] Age Inst, Helsinki, Finland.
RP Härkänen, T (corresponding author), Finnish Inst Hlth & Welf, Publ Hlth Solut, Helsinki, Finland.
EM tommi.harkanen@thl.fi
RI Peltonen, Markku/F-3037-2015; Harkanen, Tommi/G-4866-2019
OI Borodulin, Katja/0000-0001-9529-2592; Harkanen,
   Tommi/0000-0002-4577-1808; Kuulasmaa, Kari/0000-0003-2165-1411
FU Duodecim Medical Publications; Academy of Finland [266251, 307907]
FX The study received external funding from Duodecim Medical Publications
   and was supported by the Academy of Finland (grant numbers 266251 and
   307907).
CR [Anonymous], BMC PUBLIC HLTH
   [Anonymous], BMJ
   [Anonymous], 2017, R PACKAG VER
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NR 42
TC 14
Z9 14
U1 0
U2 4
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2044-6055
J9 BMJ OPEN
JI BMJ Open
PD MAR
PY 2020
VL 10
IS 3
AR e033741
DI 10.1136/bmjopen-2019-033741
PG 10
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA LG0KT
UT WOS:000527801000099
PM 32152164
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Zhao, W
   Tong, JJ
   Liu, J
   Liu, J
   Li, JH
   Cao, YT
AF Zhao, Wei
   Tong, Jingjing
   Liu, Jie
   Liu, Jin
   Li, Jinghua
   Cao, Yongtong
TI The Dose-Response Relationship between Gamma-Glutamyl Transferase and
   Risk of Diabetes Mellitus Using Publicly Available Data: A Longitudinal
   Study in Japan
SO INTERNATIONAL JOURNAL OF ENDOCRINOLOGY
LA English
DT Article
ID MIDDLE-AGED MEN; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   CIGARETTE-SMOKING; OXIDATIVE STRESS; LIVER-ENZYMES; ALCOHOL-USE;
   HYPERTENSION; PREDICTOR; OBESITY
AB Purpose. The purpose of this study was to examine the association between baseline serum gamma-glutamyl transferase (GGT) and incident diabetes mellitus and to explore their dose-response relationship in a cohort of Japanese adults. Patients and Methods. Data were drawn from the NAGALA (NAfld in the Gifu Area, Longitudinal Analysis) study between 2004 and 2015, including hierarchical information on participants >= 18 years of age without diabetes mellitus, preexisting diabetes mellitus, heavy alcohol drinking, or other liver diseases (e.g., hepatitis B/C). The final analytic sample included 15464 participants, 373 of who were diagnosed as diabetes mellitus with a maximum 13-year follow-up. The risk of incident diabetes mellitus according to baseline serum GGT was estimated using multivariable Cox proportional hazards models and a two-piecewise linear regression model was developed to find out the threshold effect. Results. Being in the highest quintile versus the lowest quintile of GGT levels was associated with an almost twofold increased risk of incident diabetes mellitus (hazard ratio 1.83 (95% CI 1.06, 3.15)), independent of age, gender, smoking status, alcohol intake, BMI, SBP, triglycerides, fatty liver, ALT, AST, and fasting plasma glucose. Further analysis revealed a positive curvilinear association between GGT and incident diabetes mellitus, with a saturation effect predicted at 24 IU/L. When serum GGT level was less than 24 IU/L, the risk of developing diabetes mellitus increased significantly with an increase in serum GGT levels (HR 1.04 (1.02, 1.07), P=0.0017). Besides, the association was more significant in nonsmoking participants than ex- or current-smokers (P for interaction = 0.0378). Conclusion. Serum GGT level was a significant predictor of subsequent risk of diabetes mellitus, which increased by 4% for every 1 IU/L increase in GGT when GGT was less than 24 IU/L.
C1 [Zhao, Wei; Li, Jinghua; Cao, Yongtong] China Japan Friendship Hosp, Dept Clin Lab, Beijing 100029, Peoples R China.
   [Tong, Jingjing] Peoples Liberat Army Gen Hosp, Med Ctr 5, Liver Failure Treatment & Res Ctr, Beijing 100039, Peoples R China.
   [Liu, Jie] Chinese Peoples Liberat Army Gen Hosp, Dept Vasc & Endovasc Surg, Beijing 100853, Peoples R China.
   [Liu, Jin] Watson Longcheng Technol & Trade Co Ltd, Beijing 100020, Peoples R China.
C3 China-Japan Friendship Hospital; Chinese People's Liberation Army
   General Hospital; Chinese People's Liberation Army General Hospital
RP Li, JH; Cao, YT (corresponding author), China Japan Friendship Hosp, Dept Clin Lab, Beijing 100029, Peoples R China.
EM zhaowei83692240@163.com; tongjingjingcat@163.com; liujie3514@163.com;
   774633585@qq.com; lijinghua620524@163.com; caoyongtong100@sina.com
RI Li, Jinghua/AGS-4025-2022; Zhao, Wei/HGU-4150-2022
OI ZHAO, Wei/0000-0003-2498-1272
CR Amer Diabet Assoc, 2010, DIABETES CARE, V33, pS11, DOI [10.2337/dc10-S011, 10.2337/dc10-S062, 10.2337/dc13-S011, 10.2337/dc13-S067, 10.2337/dc11-S011, 10.2337/dc14-S081, 10.2337/dc12-s064, 10.2337/dc11-S062, 10.2337/dc12-s011]
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NR 34
TC 18
Z9 20
U1 0
U2 3
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1687-8337
EI 1687-8345
J9 INT J ENDOCRINOL
JI Int. J. Endocrinol.
PD FEB 21
PY 2020
VL 2020
AR 5356498
DI 10.1155/2020/5356498
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA KS9ID
UT WOS:000518620700002
PM 32215009
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Kouvari, M
   Panagiotakos, DB
   Yannakoulia, M
   Georgousopoulou, E
   Critselis, E
   Chrysohoou, C
   Tousoulis, D
   Pitsavos, C
   Skoumas, Y
   Katinioti, N
   Papadimitriou, L
   Masoura, C
   Vellas, S
   Lentzas, Y
   Kambaxis, M
   Paliou, K
   Metaxa, 
   Skourlis, N
   Papanikolaou, C
   Kalogeropoulou, A
   Pitaraki, E
   Laskaris, A
   Hatzigeorgiou, M
   Grekas, A
   Kokkou, E
   Vassiliadou, C
   Dedousis, G
   Toutouza-Giotsa, M
   Tselika, C
   Poulopouloou, S
   Toutouza, M
AF Kouvari, Matina
   Panagiotakos, Demosthenes B.
   Yannakoulia, Mary
   Georgousopoulou, Ekavi
   Critselis, Elena
   Chrysohoou, Christina
   Tousoulis, Dimitrios
   Pitsavos, Christos
   Skoumas, Y.
   Katinioti, N.
   Papadimitriou, L.
   Masoura, C.
   Vellas, S.
   Lentzas, Y.
   Kambaxis, M.
   Paliou, K.
   Metaxa, V
   Skourlis, N.
   Papanikolaou, C.
   Kalogeropoulou, A.
   Pitaraki, E.
   Laskaris, A.
   Hatzigeorgiou, M.
   Grekas, A.
   Kokkou, E.
   Vassiliadou, C.
   Dedousis, G.
   Toutouza-Giotsa, M.
   Tselika, C.
   Poulopouloou, S.
   Toutouza, M.
CA ATTICA Study Investigators
TI Transition from metabolically benign to metabolically unhealthy obesity
   and 10-year cardiovascular disease incidence: The ATTICA cohort study
SO METABOLISM-CLINICAL AND EXPERIMENTAL
LA English
DT Article
DE Obesity metabolically benign; Heart disease; Gender; Primary prevention;
   Inflammation; Insulin resistance
ID HEALTHY OBESITY; MEDITERRANEAN DIET; NORMAL-WEIGHT; OXIDATIVE STRESS;
   FOLLOW-UP; ALL-CAUSE; RISK; BIOMARKERS; PHENOTYPES; OVERWEIGHT
AB Background/Objectives: Metabolically benign obesity remains a scientific field of considerable debate. The aim of the present work was to evaluate whether metabolically healthy obese (MHO) status is a transient condition which propagates 10-year cardiovascular disease (CVD) onset.
   Methods: A prospective longitudinal study was conducted during 2001-2012, the ATTICA study studying 1514 (49.8%) men and 1528 (50.2%) women (aged >18 years old) free of CVD and residing in the greater Athens area, Greece. Follow-up assessment of first combined CVD event (2011-2012) was achieved in n 2020 participants; of them, 317 (15.7%) incident cases were identified. Obesity was defined as body mass index >= 30 kg/m(2) and healthy metabolic status as absence of all NCEP ATP III (2005) metabolic syndrome components (excluding waist circumference).
   Results: The MHO prevalence was 4.8% (n = 146) with 28.2% of obese participants presenting metabolically healthy status at baseline. Within this group, 52% developed unhealthy metabolic status during the 10-year follow up. MHO vs. metabolically healthy non-obese participants had a higher likelihood of presenting with 10-year CVD events, yet only the subset of them who lost their baseline status reached the level of significance (Hazard Ratio (HR) 1.43, 95% Confidence Interval (95% CI) 1.02, 2.01). Sensitivity analyses revealed that MHO status was independently associated with elevated CVD risk in women and participants with low adherence to the Mediterranean diet, low grade inflammation, and insulin resistance.
   Conclusions: MHO status is a transient condition where weight management is demanded to prevent the establishment of unhealthy cardiometabolic features. The existence of obese persons who remain "longitudinally" resilient to metabolic abnormalities is an emerging area of future research. (C) 2019 Elsevier Inc. All rights reserved.
C1 [Kouvari, Matina; Panagiotakos, Demosthenes B.; Yannakoulia, Mary; Georgousopoulou, Ekavi; Critselis, Elena] Harokopio Univ, Sch Hlth Sci & Educ, Dept Nutr & Dietet, Athens, Greece.
   [Chrysohoou, Christina; Tousoulis, Dimitrios; Pitsavos, Christos] Univ Athens, Sch Med, Cardiol Clin 1, Athens, Greece.
   [Panagiotakos, Demosthenes B.] Rutgers State Univ, Sch Arts & Sci, Dept Kinesiol & Hlth, New Brunswick, NJ USA.
   [Panagiotakos, Demosthenes B.] Univ Canberra, Fac Hlth, Canberra, ACT, Australia.
   [Panagiotakos, Demosthenes B.] La Trobe Univ, Coll Sci Hlth & Engn, Sch Allied Hlth, Bundoora, Vic, Australia.
   [Georgousopoulou, Ekavi] Australian Natl Univ, Med Sch, Canberra, ACT, Australia.
C3 Harokopio University Athens; National & Kapodistrian University of
   Athens; Athens Medical School; Rutgers University System; Rutgers
   University New Brunswick; University of Canberra; La Trobe University;
   Australian National University
RP Panagiotakos, DB (corresponding author), Harokopio Univ, Sch Hlth Sci & Educ, Dept Nutr & Dietet, Athens, Greece.
EM d.b.panagiotakos@usa.net
RI Panagiotakos, Demosthenes/K-8294-2019; Georgousopoulou,
   Ekavi/AAC-2563-2019; Dedoussis, George/AAN-7252-2021; Kouvari,
   Matina/P-2308-2017
OI Kouvari, Matina/0000-0002-1558-194X; Yannakoulia,
   Mary/0000-0003-2171-7337; Georgousopoulou, Ekavi/0000-0002-0592-3838;
   Chrysohoou, Christina/0000-0002-6340-3996
FU Hellenic Cardiology Society [HCS2002]; Hellenic Atherosclerosis Society
   [HAS2003]; Hellenic Atherosclerosis Society
FX The ATTICA study is supported by research grants from the Hellenic
   Cardiology Society [HCS2002] and the Hellenic Atherosclerosis Society
   [HAS2003]. The present work is also supported by a research grant from
   Hellenic Atherosclerosis Society.
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NR 38
TC 100
Z9 103
U1 0
U2 9
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0026-0495
EI 1532-8600
J9 METABOLISM
JI Metab.-Clin. Exp.
PD APR
PY 2019
VL 93
BP 18
EP 24
DI 10.1016/j.metabol.2019.01.003
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA IB5IP
UT WOS:000470305100004
PM 30639450
DA 2025-06-11
ER

PT J
AU Zhu, Q
   Zhu, YY
   Wang, WN
AF Zhu, Qing
   Zhu, Yong-Yi
   Wang, Wei-Ning
TI TRUSS inhibition protects against high fat diet (HFD)-stimulated brain
   injury by alleviation of inflammatory response
SO BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
LA English
DT Article
DE High fat diet; TRUSS; Cognitive impairments; Inflammation; IKK alpha/I
   kappa B alpha/NF-kappa B
ID INSULIN-RESISTANCE; COGNITIVE FUNCTION; OXIDATIVE STRESS; KAPPA-B;
   OBESITY; ACTIVATION; NEUROINFLAMMATION; MICROGLIA; HAPLOTYPE; TRPC4AP
AB High fat diet (HFD)-induced obesity is associated with insulin resistance (IR) and other chronic, diet associated illnesses, including neuroinflammation and brain injury. However, the involvement of inflammatory response in HFD-elicited central nerve injury has yet to be fully determined. Recent studies have indicated that tumor necrosis factor receptor-associated ubiquitous scaffolding and signaling protein (TRUSS), also known as TRPC4AP, plays an essential role in regulating inflammation via the meditation of NF-kappa B signaling. In the present study, we attempted to explore the effects of TRUSS on HFD-induced brain injury in the wild type mice (TRUSS+/+) or TRUSS-knockout mice (TRUSS-/-). The results suggested that TRUSS deletion attenuated HFD-induced cognitive impairments in mice. HFD-elicited metabolic disorders were also highly improved by the loss of TRUSS, as evidenced by the reduced serum glucose and insulin levels, as well as the lipid deposition in liver tissues. In addition, HFD-triggered brain injury was markedly alleviated by the TRUSS ablation, as proved by the reduction of GFAP and Ibal expressions in hippocampus and hypothalamus. Moreover, TRUSS-/- mice exhibited a significant decrease in the expression of pro-inflammatory cytokines, accompanied with the inactivation of IKK alpha/I kappa B alpha/NF-kappa B pathway. At the same time, HFD-induced dyslipidemia was also alleviated by the loss of TRUSS. The in vitro study verified the protective effects of TRUSS-suppression against HFD-induced central nerve injury and hepatic steatosis by restraining the inflammatory response. In summary, our data indicated that TRUSS participated in metabolic syndrome-induced brain injury and pointed to the repression of TRUSS as a promising strategy for cognitive deficits therapy. (C) 2019 Published by Elsevier Inc.
C1 [Zhu, Qing] Ganzhou Peoples Hosp, Dept Pain, Ganzhou 341000, Jiangxi, Peoples R China.
   [Zhu, Yong-Yi] Guangzhou Med Univ, Affiliated Hosp 5, Dept Anesthesiol, Guangzhou 510700, Guangdong, Peoples R China.
   [Wang, Wei-Ning] Shanxian Cent Hosp, Jining Med Coll, Affiliated Huxi Hosp, Dept Anesthesiol, Shanxian 274300, Shandong, Peoples R China.
C3 Guangzhou Medical University; Jining Medical University
RP Wang, WN (corresponding author), Shanxian Cent Hosp, Jining Med Coll, Affiliated Huxi Hosp, 1 Wenhua Rd, Shanxian 274300, Shandong, Peoples R China.
EM wwnkiss@foxmail.com
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NR 36
TC 7
Z9 7
U1 0
U2 13
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0006-291X
EI 1090-2104
J9 BIOCHEM BIOPH RES CO
JI Biochem. Biophys. Res. Commun.
PD MAR 26
PY 2019
VL 511
IS 1
BP 41
EP 48
DI 10.1016/j.bbrc.2019.01.058
PG 8
WC Biochemistry & Molecular Biology; Biophysics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics
GA HO3VA
UT WOS:000460849800007
PM 30765221
DA 2025-06-11
ER

PT J
AU Kenchegowda, D
   Legesse, B
   Hritzo, B
   Olsen, C
   Aghdam, S
   Kaur, A
   Culp, W
   Derrien-Colemyn, A
   Severson, G
   Moroni, M
AF Kenchegowda, Doreswamy
   Legesse, Betre
   Hritzo, Bernadette
   Olsen, Cara
   Aghdam, Saeed
   Kaur, Amandeep
   Culp, William
   Derrien-Colemyn, Alexandrine
   Severson, Grant
   Moroni, Maria
TI Selective Insulin-like Growth Factor Resistance Associated with Heart
   Hemorrhages and Poor Prognosis in a Novel Preclinical Model of the
   Hematopoietic Acute Radiation Syndrome
SO RADIATION RESEARCH
LA English
DT Article
ID C-REACTIVE PROTEIN; NITRIC-OXIDE SYNTHASE; FACTOR-I; GOTTINGEN MINIPIG;
   ENDOTHELIAL DYSFUNCTION; METABOLIC SYNDROME; PHOSPHORYLATION;
   ACTIVATION; SURVIVAL; BIOAVAILABILITY
AB Although bone marrow aplasia has been considered for the past decades as the major contributor of radiation-induced blood disorders, cytopenias alone are insufficient to explain differences in the prevalence of bleeding. In this study, the minipig was used as a novel preclinical model of hematopoietic acute radiation syndrome to assess if factors other than platelet counts correlated with bleeding and survival. We sought to determine whether radiation affected the insulinlike growth factor-1 (IGF-1) pathway, a growth hormone with cardiovascular and radioprotective features. Gottingen and Sinclair minipigs were exposed to ionizing radiation at hematopoietic doses. The smaller Gottingen minipig strain was more sensitive to radiation; differences in IC:F-1 levels were minimal, suggesting that increased sensitivity could depend on weak response to the hormone. Radiation caused IGF-1 selective resistance by inhibiting the anti-inflammatory anti-oxidative stress IRS/PI3K/Akt but not the pro-inflammatory MAPK kinase pathway, shifting IGF-1 signaling towards a pro-oxidant, pro-inflammatory environment. Selective IGF-1 resistance associated with hemorrhages in the heart, poor prognosis, increase in C-reactive protein and NADPH oxidase 2, uncoupling of endothelial nitric oxide synthase, inhibition of nitric oxide (NO) synthesis and imbalance between the vasodilator NO and the vasoconstrictor endothelin-1 molecules. Selective IGF-1 resistance is a novel mechanism of radiation injury, associated with a vicious cycle amplifying reactive oxygen species-induced damage, inflammation and endothelial dysfunction. In the presence of thrombocytopenia, selective inhibition of IGF-1 cardioprotective function may contribute to the development of hemostatic disorders. This finding may be particularly relevant for individuals with low IGF-1 activity, such as the elderly or those with cardiometabolic dysfunctions. (C) 2018 by Radiation Research Society
C1 [Kenchegowda, Doreswamy; Legesse, Betre; Hritzo, Bernadette; Aghdam, Saeed; Kaur, Amandeep; Derrien-Colemyn, Alexandrine; Severson, Grant; Moroni, Maria] Armed Forces Radiobiol Res Inst, Sci Res Dept, Bethesda, MD USA.
   [Olsen, Cara] Uniformed Serv Univ Hlth Sci, Biostat Consulting Ctr, Bethesda, MD 20814 USA.
   [Culp, William] Uniformed Serv Univ Hlth Sci, Off Vice President Res, Bethesda, MD 20814 USA.
C3 United States Department of Defense; Uniformed Services University of
   the Health Sciences - USA; Uniformed Services University of the Health
   Sciences - USA
RP Moroni, M (corresponding author), Armed Forces Radiobiol Res Inst, Bldg 42,8901 Wisconsin Ave, Bethesda, MD 20889 USA.
EM maria.moroni@usuhs.edu
RI Kenchegowda, Doreswamy/F-2498-2012; Kaur, Amandeep/IYJ-2622-2023
FU National Institute of Allergy and Infectious Diseases [OD-0505-01];
   BARDA [IAA750114PR970036]
FX This work was supported by funding from National Institute of Allergy
   and Infectious Diseases OD-0505-01, BARDA IAA750114PR970036. Special
   thanks to the AFRRI Cobalt facility and the Veterinary Sciences
   Department staff for their dedication to the project and superb animal
   care. The opinions or assertions contained herein are the private views
   of the authors and are not necessarily those of the Armed Forces
   Radiobiology Research Institute (AFRRI), the Uniformed Services
   University of the Health Sciences or the Department of Defense. The
   funding agencies had no role in study design, data collection and
   analysis, decision to publish or preparation of the manuscript.
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NR 59
TC 17
Z9 17
U1 0
U2 6
PU RADIATION RESEARCH SOC
PI LAWRENCE
PA 810 E TENTH STREET, LAWRENCE, KS 66044 USA
SN 0033-7587
EI 1938-5404
J9 RADIAT RES
JI Radiat. Res.
PD AUG
PY 2018
VL 190
IS 2
BP 164
EP 175
DI 10.1667/RR14993.1
PG 12
WC Biology; Biophysics; Radiology, Nuclear Medicine & Medical Imaging
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics; Biophysics; Radiology,
   Nuclear Medicine & Medical Imaging
GA GO5PR
UT WOS:000440077400007
PM 29809108
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Karadeniz, Y
   Onat, A
   Akbas, T
   Simsek, B
   Yüksel, H
   Can, G
AF Karadeniz, Yusuf
   Onat, Altan
   Akbas, Tugba
   Simsek, Baris
   Yuksel, Husniye
   Can, Gunay
TI Determinants of obstructive sleep apnea syndrome: Pro-inflammatory state
   and dysfunction of high-density lipoprotein
SO NUTRITION
LA English
DT Article
DE Elevated fibrinogen; Neck circumference; Obstructive sleep apnea;
   Oxidative stress; Smoking status
ID METABOLIC SYNDROME; RISK-FACTORS; CARDIOVASCULAR-DISEASE;
   INSULIN-RESISTANCE; HEART HEALTH; ASSOCIATION; POPULATION; PREVALENCE;
   DEFINITION; OBESITY
AB Objective: The goal of this study was to determine variables preceding and predicting incident obstructive sleep apnea syndrome (OSAS) in the population at large.
   Methods: Anthropometric, lipid, and non-lipid variables in participants with newly developing OSAS (n = 131) were compared with those of a cohort sample (n = 2615) of the Turkish Adult Risk Factor study. Available values preceding (by a median of 32 mo) the development of OSAS were used in multivariable Cox regression models.
   Results: Significant determinants of OSAS assessed by group differences were waist/neck circumference and fibrinogen. Fasting triacylglycerols, systolic blood pressure, and C-reactive protein in men and low sex hormone-binding globulin and elevated homeostatic model assessment in women were further significant covariates. Cox regression analysis for the risk of incident OSAS confirmed the independent predictive value of central obesity measures, especially neck circumference (having a twofold hazard ratio) and younger age. Age-adjusted former smoking status and-compared with the lowest-tertile the upper two tertiles of fibrinogen (relative risk = 1.66, 95% confidence interval: 1.05-2.63) were significant predictors. Elevated triacylglycerols in males and high apolipoprotein B and lowest high-density lipoprotein cholesterol tertile in females also predicted subsequent OSAS. Systolic blood pressure and total cholesterol did not prove to be independent predictors in multi variable adjusted Cox models in which partial sex-dependent independence of obesity measures of the previously stated five variables was essentially retained.
   Conclusions: An enhanced pro-inflammatory state appeared to be the underlying pathophysiologic mechanism for OSAS, whereas in men, the added factor of high-density lipoprotein dysfunction was suggested. Because it contributes to the pro-inflammatory state, discontinuance of smoking was another further significant predictor of OSAS. (C) 2017 Elsevier Inc. All rights reserved.
C1 [Karadeniz, Yusuf] Ataturk Univ, Fac Med, Dept Endocrinol & Metab, Erzurum, Turkey.
   [Onat, Altan; Yuksel, Husniye] Istanbul Univ, Cerrahpasa Med Fac, Dept Cardiol, Istanbul, Turkey.
   [Akbas, Tugba] Bagcilar Educ Hosp, Istanbul, Turkey.
   [Simsek, Baris] Siyami Ersek Ctr Cardiovasc Surg, Sect Cardiol, Istanbul, Turkey.
   [Can, Gunay] Istanbul Univ, Cerrahpasa Med Fac, Dept Publ Hlth, Istanbul, Turkey.
C3 Ataturk University; Istanbul University; Istanbul University -
   Cerrahpasa; Istanbul Bagcilar Training & Research Hospital; Dr. Siyami
   Ersek Cardiac & Vascular Surgery Training & Research Hospital; Istanbul
   University; Istanbul University - Cerrahpasa
RP Onat, A (corresponding author), Istanbul Univ, Cerrahpasa Med Fac, Dept Cardiol, Istanbul, Turkey.
EM alt_onat@yahoo.com.tr
RI Can, Günay/AAB-1669-2020; Karadeniz, Yusuf/JAC-5120-2023
OI Karadeniz, Yusuf/0000-0002-6113-3259; CAN, GUNAY/0000-0001-5815-6700
FU TOFAS, Istanbul, Turkey
FX We acknowledge the financial support of the automotive firm TOFAS,
   Istanbul, Turkey, and appreciate the logistic support by the Turkish
   Ministry of Health.
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NR 33
TC 3
Z9 3
U1 0
U2 8
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0899-9007
EI 1873-1244
J9 NUTRITION
JI Nutrition
PD NOV-DEC
PY 2017
VL 43-44
BP 54
EP 60
DI 10.1016/j.nut.2017.06.021
PG 7
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA FJ4NH
UT WOS:000412716700008
PM 28935145
DA 2025-06-11
ER

PT J
AU Kani, AH
   Alavian, SM
   Esmaillzadeh, A
   Adibi, P
   Haghighatdoost, F
   Azadbakht, L
AF Kani, Ali Hashemi
   Alavian, Seyed Moayed
   Esmaillzadeh, Ahmad
   Adibi, Peyman
   Haghighatdoost, Fahimeh
   Azadbakht, Leila
TI Effects of a Low-Calorie, Low-Carbohydrate Soy Containing Diet on
   Systemic Inflammation Among Patients with Nonalcoholic Fatty Liver
   Disease: A Parallel Randomized Clinical Trial
SO HORMONE AND METABOLIC RESEARCH
LA English
DT Article
DE soy; low-calorie diet; low-carbohydrate diet; inflammation; leptin;
   nonalcoholic fatty liver
ID C-REACTIVE PROTEIN; POSTMENOPAUSAL WOMEN; INSULIN-RESISTANCE; METABOLIC
   SYNDROME; OXIDATIVE STRESS; RISK-FACTORS; BODY-WEIGHT; NEPHROPATHY;
   LEPTIN; INDIVIDUALS
AB Few studies have focused on the effects of a soy containing diet on inflammation and serum leptin level among patients with nonalcoholic fatty liver disease (NAFLD). Therefore, we aimed to determine the effects of such a diet in patients with NAFLD. Forty-five patients with NAFLD participated in this parallel randomized clinical trial for 8 weeks. Patients were randomly allocated to these 3 groups: 1) a low-calorie diet, 2) low-calorie low-carbohydrate diet, and 3) low-calorie low-carbohydrate soy containing diet. Low-calorie low-carbohydrate soy containing diet reduced fasting blood sugar (FBS) and serum insulin level significantly compared to other 2 groups (-11.6 +/- 2.8 vs. -6.3 +/- 1.7 and -3.1 +/- 1.0 mg/dl for FBS; and -5.1 +/- 1.2 vs. -1.2 +/- 0.3 and -1.7 +/- 0.5 mg/dl for serum insulin level). Serum hs-CRP level was also reduced significantly following low-calorie low-carbohydrate soy containing diet (-0.8 +/- 0.1 vs. -0.1 +/- 0.06 and -0.1 +/- 0.06 mg/dl). Both systolic and diastolic blood pressures were reduced significantly. Changes in leptin level tended to be different among 3 groups. After trial, 5 patients in each intervention group did not have NAFLD. From 6 patients in grade 2 at the beginning only 1 patient remained and others moved to grade 1. Low-calorie low-carbohydrate soy containing diet could reduce glycemic indices, hs CRP, systolic and diastolic blood pressure in a significant level in patients with NAFLD. However, these effects were dependent on baseline weight and further studies are needed to clarify the effect of such interventions in subjects with different BMI categories.
C1 [Kani, Ali Hashemi; Esmaillzadeh, Ahmad; Haghighatdoost, Fahimeh; Azadbakht, Leila] Isfahan Univ Med Sci, Food Secur Res Ctr, Esfahan, Iran.
   [Kani, Ali Hashemi; Esmaillzadeh, Ahmad; Haghighatdoost, Fahimeh; Azadbakht, Leila] Isfahan Univ Med Sci, Sch Nutr & Food Sci, Dept Community Nutr, Esfahan, Iran.
   [Kani, Ali Hashemi] Shahid Beheshti Univ Med Sci, Laser Applicat Med Sci Res Ctr, Tehran, Iran.
   [Alavian, Seyed Moayed] Baqiyatallah Univ Med Sci, Baqiyatallah Res Ctr Gastroenterol & Liver Dis, Tehran, Iran.
   [Esmaillzadeh, Ahmad] Univ Tehran Med Sci, Endocrinol & Metab Mol Cellular Sci Inst, Obes & Eating Habits Res Ctr, Tehran, Iran.
   [Adibi, Peyman] Isfahan Univ Med Sci, Integrat Funct Gastroenterol Res Ctr, Esfahan, Iran.
   [Azadbakht, Leila] Univ Tehran Med Sci, Endocrinol & Metab Clin Sci Inst, Diabet Res Ctr, Tehran, Iran.
   [Azadbakht, Leila] Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Community Nutr, Tehran, Iran.
C3 Isfahan University of Medical Sciences; Isfahan University of Medical
   Sciences; Shahid Beheshti University Medical Sciences; Baqiyatallah
   University of Medical Sciences (BMSU); Tehran University of Medical
   Sciences; Isfahan University of Medical Sciences; Tehran University of
   Medical Sciences; Tehran University of Medical Sciences
RP Azadbakht, L (corresponding author), Isfahan Univ Med Sci, Sch Nutr & Food Sci, Dept Community Nutr, Esfahan, Iran.
EM azadbakht@hlth.mui.ac.ir
RI Ghorashi, Seyed/C-1529-2016; Azadbakht, Leila/N-2801-2018; Esmaillzadeh,
   Ahmad/N-5704-2014; Adibi Sedeh, Peyman/AAJ-4582-2020
OI Azadbakht, Leila/0000-0002-5955-6818; Esmaillzadeh,
   Ahmad/0000-0002-8735-6047; Adibi Sedeh, Peyman/0000-0001-6411-5235
FU research council and ethics committee of Food Security Research center,
   Isfahan University of Medical Sciences, Isfahan Iran [185190]; School of
   nutrition and Food Science, Isfahan University of Medical Sciences,
   Isfahan Iran [185190]
FX Financial support by the research council and ethics committee of Food
   Security Research center and School of nutrition and Food Science,
   Isfahan University of Medical Sciences (Research project number:
   185190), Isfahan Iran is acknowledged.
CR Ahmed MH, 2012, J OBES, V2012, DOI 10.1155/2012/483135
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NR 34
TC 30
Z9 30
U1 2
U2 15
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0018-5043
EI 1439-4286
J9 HORM METAB RES
JI Horm. Metab. Res.
PD SEP
PY 2017
VL 49
IS 9
BP 687
EP 692
DI 10.1055/s-0042-118707
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA FG6UI
UT WOS:000410529100007
PM 28759939
DA 2025-06-11
ER

PT J
AU Moon, G
   Kim, J
   Min, Y
   Wi, SM
   Shim, JH
   Chun, E
   Lee, KY
AF Moon, Gyuyoung
   Kim, Juhong
   Min, Yoon
   Wi, Sae Mi
   Shim, Jae-Hyuck
   Chun, Eunyoung
   Lee, Ki-Young
TI Phosphoinositide-dependent kinase-1 inhibits TRAF6 ubiquitination by
   interrupting the formation of TAK1-TAl32 complex in TLR4 signaling
SO CELLULAR SIGNALLING
LA English
DT Article
DE PDK1; TLR4; TAK1; TRAF6; TAB2; Ubiquitination
ID NF-KAPPA-B; METABOLIC SYNDROME; ADAPTER PROTEIN; TAK1; ACTIVATION; IL-1;
   INNATE; TAB2; INSIGHTS; IKK
AB Phosphoinositide-dependent protein kinase 1 (PDK1) plays a key role in the phosphoinositide 3-kinase (PI3K) PDK1-Akt pathway that induces cell survival and cardiovascular protections through anti-apoptosis, vasodilation, anti-inflammation, and anti-oxidative stress activities. Although several reports have proposed the negative role of PDK1 in Toll-like receptor 4 (TLR4) signaling, the molecular mechanism is still unknown. Here we show that PDK1 inhibits tumor necrosis factor (TNF) receptor-associated factor 6 (TRAF6) ubiquitination by interrupting the complex between transforming growth factor beta-activated kinase 1 (TAK1) and TAK1 binding protein 2 (TAB2), which negatively regulates TAK1 activity. The overexpression of PDK1 in 293/TLR4 cells resulted in suppressions of nuclear factor kappa B (NF-kappa B) activation and production of proinflammatory cytokines including interleukin (IL)-6 and TNF-alpha in response to lipopolysaccharide stimulation. Conversely, THP-1 human monocytes transiently cultured in low glucose medium displayed down-regulated PDK1 expression, and significantly enhanced TLR4-mediated signaling for the activation of NF-kappa B, demonstrating a negative role of PDK1. Biochemical studies revealed that PDK1 significantly interacted with TAK1, resulting in the inhibition of the association of TAB2 with TAK1, which led to the attenuation of TRAF6 ubiquitination. Moreover, PDK1-knockdown THP-1 cells displayed enhancement of downstream signals, activation of NF-kappa B, and increased production of proinflammatory cytokines IL-6, IL-1 beta, and TNF-alpha, which potentially led to the up-regulation of NF-kappa B-dependent genes in response to TLR4 stimulation. Collectively, the results demonstrate that PDK1 inhibits the formation of the TAK1 TAB2 TRAF6 complex and leads to the inhibition of TRAF6 ubiquitination, which negatively regulates the TLR4-mediated signaling for NF-kappa B activation. (C) 2015 Elsevier Inc. All rights reserved.
C1 [Moon, Gyuyoung; Kim, Juhong; Min, Yoon; Wi, Sae Mi; Lee, Ki-Young] Sungkyunkwan Univ, Sch Med, Dept Mol Cell Biol, Suwon 440746, South Korea.
   [Moon, Gyuyoung; Kim, Juhong; Min, Yoon; Wi, Sae Mi; Lee, Ki-Young] Sungkyunkwan Univ, Sch Med, Samsung Biomed Res Inst, Suwon 440746, South Korea.
   [Shim, Jae-Hyuck] Weill Cornell Med Coll, Dept Pathol & Lab Med, New York, NY 10065 USA.
   [Chun, Eunyoung] Harvard Univ, Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USA.
   [Chun, Eunyoung] Harvard Univ, Sch Med, Dept Med, Boston, MA 02115 USA.
C3 Sungkyunkwan University (SKKU); Sungkyunkwan University (SKKU); Cornell
   University; Weill Cornell Medicine; Harvard University; Harvard T.H.
   Chan School of Public Health; Harvard University; Harvard Medical School
RP Lee, KY (corresponding author), Sungkyunkwan Univ, Sch Med, Dept Mol Cell Biol, Suwon 440746, South Korea.
EM thylee@skku.edu
FU Mid-career Researcher Program through an NRF [NRF-2014R1A2A1A11053221]
FX This work was supported by the Mid-career Researcher Program through an
   NRF grant (NRF-2014R1A2A1A11053221). We would like to thank the Hyehwa
   Forum members for their helpful discussions.
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NR 36
TC 26
Z9 27
U1 0
U2 12
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0898-6568
EI 1873-3913
J9 CELL SIGNAL
JI Cell. Signal.
PD DEC
PY 2015
VL 27
IS 12
BP 2524
EP 2533
DI 10.1016/j.cellsig.2015.09.018
PG 10
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA DA0KQ
UT WOS:000367486400021
PM 26432169
DA 2025-06-11
ER

PT J
AU Veilleux, A
   Mayeur, S
   Bérubé, JC
   Beaulieu, JF
   Tremblay, E
   Hould, FS
   Bossé, Y
   Richard, D
   Levy, E
AF Veilleux, Alain
   Mayeur, Sylvain
   Berube, Jean-Christophe
   Beaulieu, Jean-Francois
   Tremblay, Eric
   Hould, Frederic-Simon
   Bosse, Yohan
   Richard, Denis
   Levy, Emile
TI Altered intestinal functions and increased local inflammation in
   insulin-resistant obese subjects: a gene-expression profile analysis
SO BMC GASTROENTEROLOGY
LA English
DT Article
ID FREE FATTY-ACIDS; LIPOPROTEIN OVERPRODUCTION; APOLIPOPROTEIN B-48;
   PSAMMOMYS-OBESUS; ACUTE ELEVATION; CELL-FUNCTION; ANIMAL-MODEL;
   BETA-CELL; PROTEIN; METABOLISM
AB Background: Metabolic alterations relevant to postprandial dyslipidemia were previously identified in the intestine of obese insulin-resistant subjects. The aim of the study was to identify the genes deregulated by systemic insulin resistance in the intestine of severely obese subjects.
   Methods: Transcripts from duodenal samples of insulin-sensitive (HOMA-IR < 3, n = 9) and insulin-resistant (HOMA-IR > 7, n = 9) obese subjects were assayed by microarray (Illumina HumanHT-12).
   Results: A total of 195 annotated genes were identified as differentially expressed between these two groups (Fold change > 1.2). Of these genes, 36 were found to be directly involved in known intestinal functions, including digestion, extracellular matrix, endocrine system, immunity and cholesterol metabolism. Interestingly, all differentially expressed genes (n = 8) implicated in inflammation and oxidative stress were found to be upregulated in the intestine of insulin-resistant compared to insulin-sensitive subjects. Metabolic pathway analysis revealed that several signaling pathways involved in immunity and inflammation were significantly enriched in differently expressed genes and were predicted to be activated in the intestine of insulin-resistant subjects. Using stringent criteria (Fold change > 1.5; FDR < 0.05), three genes were found to be significantly and differently expressed in the intestine of insulin-resistant compared to insulin-sensitive subjects: the transcripts of the insulinotropic glucose-dependant peptide (GIP) and of the beta-microseminoprotein (MSMB) were significantly reduced, but that of the humanin like-1 (MTRNR2L1) was significantly increased.
   Conclusion: These results underline that systemic insulin resistance is associated with remodeling of key intestinal functions. Moreover, these data indicate that small intestine metabolic dysfunction is accompanied with a local amplification of low-grade inflammatory process implicating several pathways. Genes identified in this study are potentially triggered throughout the development of intestinal metabolic abnormalities, which could contribute to dyslipidemia, a component of metabolic syndrome and diabetes.
C1 [Veilleux, Alain; Mayeur, Sylvain; Levy, Emile] Univ Montreal, Dept Nutr, Montreal, PQ H3C 3J7, Canada.
   [Veilleux, Alain; Mayeur, Sylvain; Levy, Emile] CHU St Justine, Res Ctr, Montreal, PQ, Canada.
   [Berube, Jean-Christophe; Hould, Frederic-Simon; Bosse, Yohan; Richard, Denis] Univ Laval, Inst Univ Cardiol & Pneumol Quebec CRIUCPQ, Quebec City, PQ, Canada.
   [Beaulieu, Jean-Francois; Tremblay, Eric] Univ Sherbrooke, Dept Anat & Cellular Biol, Sherbrooke, PQ J1K 2R1, Canada.
   [Beaulieu, Jean-Francois] Canada Res Chair Intestinal Physiopathol, Sherbrooke, PQ, Canada.
   [Hould, Frederic-Simon] Univ Laval, Dept Surg, Quebec City, PQ, Canada.
   [Bosse, Yohan; Richard, Denis] Univ Laval, Dept Mol Med, Quebec City, PQ, Canada.
   [Richard, Denis] Chaire Rech Merck Frosst IRSC Res Chair Obes, Quebec City, PQ, Canada.
   [Levy, Emile] JA deSeve Res Chair Nutr, Montreal, PQ, Canada.
C3 Universite de Montreal; Universite de Montreal; Centre Hospitalier
   Universitaire Sainte-Justine; Laval University; University of
   Sherbrooke; Laval University; Laval University
RP Levy, E (corresponding author), Univ Montreal, Dept Nutr, 3175 Cote Ste Catherine, Montreal, PQ H3C 3J7, Canada.
EM emile.levy@recherche-ste-justine.qc.ca
RI Bosse, Yohan/C-7617-2012; Beaulieu, Jean-Francois/D-2054-2010; Veilleux,
   Alain/I-5028-2019
OI Beaulieu, Jean-Francois/0000-0002-8977-3629; Berube,
   Jean-Christophe/0000-0002-7634-5270; Veilleux, Alain/0000-0003-4078-1908
FU operating funds from the Canadian Institutes of Health Research [MOP
   10584, MOP 49433]; J.A. de Seve Research Chair in Nutrition;
   postdoctoral studentship from the Canadian Institutes of Health Research
   and the Canadian Diabetes Association; FRQS postdoctoral fellowship
   award; Junior 2 Research Scholar award from the Fonds de recherche
   Quebec - Sante (FRQS)
FX We acknowledge the contribution of the bariatric surgeons group at the
   Institut universitaire de cardiologie et de pneumologie de Quebec
   (IUCPQ). We would like to thank Dr Benoit Lamarche (Nutraceuticals and
   Functional Food Institute (INAF), Laval University, Quebec) for his
   assistance in LDL size measurement. We also thank Mrs Shohraya Spahis
   (Department of Nutrition, CHU Sainte-Justine) for her technical
   assistance. The study was supported by operating funds from the Canadian
   Institutes of Health Research (MOP 10584 and MOP 49433) and J.A. de Seve
   Research Chair in Nutrition to E.L. A.V. was supported by a postdoctoral
   studentship from the Canadian Institutes of Health Research and the
   Canadian Diabetes Association. S.M. was funded by the FRQS postdoctoral
   fellowship award. Y. Bosse is the recipient of a Junior 2 Research
   Scholar award from the Fonds de recherche Quebec - Sante (FRQS).
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NR 43
TC 22
Z9 28
U1 0
U2 6
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-230X
J9 BMC GASTROENTEROL
JI BMC Gastroenterol.
PD SEP 16
PY 2015
VL 15
AR 119
DI 10.1186/s12876-015-0342-y
PG 12
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA CR7DW
UT WOS:000361509100001
PM 26376914
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Martínez-González, MA
   Salas-Salvadó, J
   Estruch, R
   Corella, D
   Fitó, M
   Ros, E
AF Martinez-Gonzalez, Miguel A.
   Salas-Salvado, Jordi
   Estruch, Ramon
   Corella, Dolores
   Fito, Montse
   Ros, Emilio
CA PREDIMED INVESTIGATORS
TI Benefits of the Mediterranean Diet: Insights From the PREDIMED Study
SO PROGRESS IN CARDIOVASCULAR DISEASES
LA English
DT Review
DE Mediterranean diet; Dietary intervention; Randomized trials; Primary
   prevention; Atrial fibrillation; Peripheral artery disease; Stroke;
   Type-2 diabetes
ID HIGH-CARDIOVASCULAR-RISK; INTIMA-MEDIA THICKNESS; HEALTHY LIFE-STYLE;
   BLOOD-PRESSURE; OLIVE OIL; METABOLIC SYNDROME; ELDERLY SUBJECTS; FOOD
   PATTERN; FIBER INTAKE; MYOCARDIAL-INFARCTION
AB The PREDIMED (PREvenciOn con DIeta MEDiterranea) multicenter, randomized, primary prevention trial assessed the long-term effects of the Mediterranean diet (MeDiet) on clinical events of cardiovascular disease (CVD). We randomized 7447 men and women at high CVD risk into three diets: MeDiet supplemented with extra-virgin olive oil (EVOO), MeDiet supplemented with nuts, and control diet (advice on a low-fat diet). No energy restriction and no special intervention on physical activity were applied. We observed 288 CVD events (a composite of myocardial infarction, stroke or CVD death) during a median time of 4.8 years; hazard ratios were 0.70 (95% CI, 0.53-0.91) for the MeDiet + EVOO and 0.70 (CI, 0.53-0.94) for the MeDiet + nuts compared to the control group. Respective hazard ratios for incident diabetes (273 cases) among 3541 non-diabetic participants were 0.60 (0.43-0.85) and 0.82 (0.61-1.10) for MeDiet + EVOO and MeDiet + nuts, respectively versus control. Significant improvements in classical and emerging CVD risk factors also supported a favorable effect of both MeDiets on blood pressure, insulin sensitivity, lipid profiles, lipoprotein particles, inflammation, oxidative stress, and carotid atherosclerosis. In nutrigenomic studies beneficial effects of the intervention with MedDiets showed interactions with several genetic variants (TCF7L2, APOA2, MLXIPL, LPL, FTO, M4CR, COX-2, GCKR and SERPINE1) with respect to intermediate and final phenotypes. Thus, the PREDIMED trial provided strong evidence that a vegetable-based MeDiet rich in unsaturated fat and polyphenols can be a sustainable and ideal model for CVD prevention. (C) 2015 Elsevier Inc. All rights reserved.
C1 [Martinez-Gonzalez, Miguel A.] Univ Navarra, Dept Prevent Med & Publ Hlth, IDISNA, Navarra Hlth Res Inst, E-31080 Pamplona, Spain.
   [Martinez-Gonzalez, Miguel A.; Salas-Salvado, Jordi; Estruch, Ramon] Inst Salud Carlos III, PREDIMED Res Network RD 06 0045, Madrid, Spain.
   [Martinez-Gonzalez, Miguel A.; Salas-Salvado, Jordi; Estruch, Ramon; Corella, Dolores; Fito, Montse; Ros, Emilio] Inst Salud Carlos III, Ctr Invest Biomed Red Fisiopatol Obesidad & Nutr, Madrid, Spain.
   [Salas-Salvado, Jordi] Univ Rovira & Virgili, Human Nutr Dept, Hosp Univ St Joan, Inst Invest Sanitaria Pere Virgili, E-43201 Reus, Spain.
   [Estruch, Ramon; Ros, Emilio] Univ Barcelona, Inst Invest Biomed August Pi & Sunyer, Hosp Clin, Barcelona, Spain.
   [Corella, Dolores] Univ Valencia, Dept Prevent Med & Publ Hlth, Valencia, Spain.
   [Fito, Montse] Inst Recerca Hosp del Mar, Cardiouasc & Nutr Res Grp, Barcelona, Spain.
C3 University of Navarra; Instituto de Salud Carlos III; CIBER - Centro de
   Investigacion Biomedica en Red; CIBEROBN; Instituto de Salud Carlos III;
   Universitat Rovira i Virgili; Institut d'Investigacio Sanitaria Pere
   Virgili (IISPV); University of Barcelona; Hospital Clinic de Barcelona;
   IDIBAPS; University of Valencia; Hospital del Mar Research Institute;
   Hospital del Mar
RP Martínez-González, MA (corresponding author), Univ Navarra, Dept Prevent Med & Publ Hlth, Sch Med, Irunlarrea 1, Navarra 31800, Spain.
EM mamartinez@unav.es
RI Corella, Dolores/L-9888-2014; Estruch, Ramon/AAZ-3723-2020;
   Martinez-Gonzalez, Miguel/AAE-7669-2019; Fito Colomer,
   Montse/C-1822-2012; Ruiz-Canela, Miguel/I-7738-2016; , MIQUEL FIOL
   SALA/F-6793-2016; Algorta, Jaime/K-9002-2012; Carrasco,
   Paula/D-7864-2019; Bullo, Monica/F-2925-2016; Salas-Salvado,
   Jordi/C-7229-2017; Prieto, Rafel M./J-3995-2017; Toledo,
   Estefania/H-6211-2014
OI Fito Colomer, Montse/0000-0002-1817-483X; BABIO SANCHEZ,
   NANCY/0000-0003-3527-5277; Corbella, Emili/0000-0001-8818-1907;
   Domenech, Monica/0000-0001-5447-6686; Guasch-Ferre,
   Marta/0000-0001-8525-1404; Marrugat, Jaume/0000-0003-3320-554X;
   Ruiz-Canela, Miguel/0000-0002-7684-2787; Martin Lujan, Francisco
   M/0000-0003-0359-3588; , MIQUEL FIOL SALA/0000-0002-5370-1391; Cabre
   Vila, Juan Jose/0000-0003-1082-6861; Algorta, Jaime/0000-0002-7042-5675;
   Vinyoles, Ernest/0000-0002-8725-9431; Romaguera,
   Dora/0000-0002-5762-8558; Ros, Emilio/0000-0002-2573-1294; Sorli, Jose
   V/0000-0002-0130-2006; Vizcaino Marin, Jesus/0000-0002-1554-5711;
   Carrasco, Paula/0000-0002-7170-4318; Castro, Antoni/0000-0001-5441-6333;
   Sanchez Villegas, Almudena/0000-0001-7733-9238; Bullo,
   Monica/0000-0002-0218-7046; Serra-Majem, Lluis/0000-0002-9658-9061;
   Salas-Salvado, Jordi/0000-0003-2700-7459; Prieto, Rafel
   M./0000-0001-8814-900X; Casas, Rosa/0000-0002-0211-9166; Toledo,
   Estefania/0000-0002-6263-4434; Basora, Josep/0000-0003-0278-1149
FU official funding agency for biomedical research of the Spanish
   government, Instituto de Salud Carlos III (ISCIII) [RTIC G03/140, RTIC
   RD 06/0045]; official funding agency for biomedical research of the
   Spanish government, Instituto de Salud Carlos III (ISCIII) through
   Centro de Investigacion Biomedica en Red de Fisiopatologia de la
   Obesidad y Nutricion (CIBERobn); Centro Nacional de Investigaciones
   Cardiovasculares (CNIC) [06/2007]; Fondo de Investigacion
   Sanitaria-Fondo Europe de Desarrollo Regional [PI04-2239, PI 05/2584,
   CP06/00100, PI07/0240, PI07/1138, PI07/0954, PI 07/0473, PI10/01407,
   PI10/02658, PI11/01647, P11/02505, PI13/01090]; Ministerio de Ciencia e
   Innovacion [AGL-2009-13906-C02, AGL2010-22319-C03]; Fundacion Mapfre;
   Consejeria de Salud de la Junta de Andalucia [PI0105/2007]; Public
   Health Division of the Department of Health of the Autonomous Government
   of Catalonia, Generalitat Valenciana [ACOMP06109, GVACOMP2010-181,
   GVACOMP2011-151, ACOMP/2013/165, ACOMP/2013/159, CS2010-AP-111,
   CS2011-AP-042]; Regional Government of Navarra [P27/2011]
FX Funding disclosure: Supported by the official funding agency for
   biomedical research of the Spanish government, Instituto de Salud Carlos
   III (ISCIII), through grants provided to research networks specifically
   developed for the trial (RTIC G03/140, to Dr. Estruch; RTIC RD 06/0045,
   to Dr. Martinez-Gonzalez) and through Centro de Investigacion Biomedica
   en Red de Fisiopatologia de la Obesidad y Nutricion (CIBERobn), and by
   grants from Centro Nacional de Investigaciones Cardiovasculares (CNIC
   06/2007), Fondo de Investigacion Sanitaria-Fondo Europe de Desarrollo
   Regional (PI04-2239, PI 05/2584, CP06/00100, PI07/0240, PI07/1138,
   PI07/0954, PI 07/0473, PI10/01407, PI10/02658, PI11/01647, P11/02505 and
   PI13/01090), Ministerio de Ciencia e Innovacion (AGL-2009-13906-C02 and
   AGL2010-22319-C03), Fundacion Mapfre 2010, Consejeria de Salud de la
   Junta de Andalucia (PI0105/2007), Public Health Division of the
   Department of Health of the Autonomous Government of Catalonia,
   Generalitat Valenciana (ACOMP06109, GVACOMP2010-181, GVACOMP2011-151,
   ACOMP/2013/165, ACOMP/2013/159, CS2010-AP-111, and CS2011-AP-042), and
   Regional Government of Navarra (P27/2011).
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NR 110
TC 526
Z9 559
U1 11
U2 12
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0033-0620
EI 1873-1740
J9 PROG CARDIOVASC DIS
JI Prog. Cardiovasc. Dis.
PD JUL-AUG
PY 2015
VL 58
IS 1
BP 50
EP 60
DI 10.1016/j.pcad.2015.04.003
PG 11
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA CM5ZH
UT WOS:000357767000007
PM 25940230
OA Green Accepted
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Choi, B
   Yeum, KJ
   Park, SJ
   Kim, KN
   Joo, NS
AF Choi, Beomhee
   Yeum, Kyung-Jin
   Park, Soo-Jung
   Kim, Kyu-Nam
   Joo, Nam-Seok
TI Elevated Serum Ferritin and Mercury Concentrations are Associated with
   Hypertension; Analysis of the Fourth and Fifth Korea National Health and
   Nutrition Examination Survey (KNHANES IV-2, 3, 2008-2009 and V-1, 2010)
SO ENVIRONMENTAL TOXICOLOGY
LA English
DT Article
DE ferritin; mercury; hypertension; Koreans
ID FATTY LIVER-DISEASE; METABOLIC SYNDROME; INSULIN-RESISTANCE;
   POLYCHLORINATED-BIPHENYLS; CARDIOVASCULAR-DISEASE; OXIDATIVE STRESS;
   RISK-FACTORS; MEN; EXPOSURE; ADULTS
AB The impact of simultaneously elevated serum ferritin and mercury concentrations on hypertension in the general population is not known. To determine the association of serum ferritin and mercury concentrations with hypertension, 6213 subjects (3060 men and 3153 women) over 20 years of age from 2008 to 2010 Korea National Health and Nutrition Examination Survey were divided into tertiles according to serum ferritin and mercury concentrations in each gender. Serum ferritin (258.2 vs. 94.8 pmol/L) and mercury concentrations (28.4 vs. 19.9 nmol/L) were higher in men than in women. Serum ferritin (men; P = 0.029, women; P < 0.001) and mercury (men; P < 0.001, women; P = 0.003) concentrations were significantly associated with the prevalence of hypertension. In addition, significant correlation between serum ferritin and mercury concentrations in both men (r = 0.193, P < 0.001) and women (r = 0.145, P < 0.001) were found. Also, the increase of serum ferritin concentrations were more prominent in men (P < 0.001) than in women (P = 0.017) as the serum mercury tertiles increased after proper adjustments. Furthermore, significantly higher odds ratios of hypertension were found in the second (OR = 1.86, 95% CI; 1.05-3.30), and third (OR = 1.84, 95% CI; 1.01-3.36) tertiles of serum ferritin with the top tertile of serum mercury in men. The current study indicate that serum ferritin and mercury concentrations are associated with the prevalence of hypertension and that simultaneously elevated serum ferritin and mercury concentrations are related to the risk for hypertension in men. (c) 2013 The Authors. The Environmental Toxicology published by Wiley Periodicals, Inc. Environ Toxicol 30: 101-108, 2015.
C1 [Choi, Beomhee] CHA Univ, CHA Antiaging Inst, Seoul, South Korea.
   [Yeum, Kyung-Jin] Konkuk Univ, Coll Biomed & Hlth Sci, Chungju Si, South Korea.
   [Park, Soo-Jung; Kim, Kyu-Nam; Joo, Nam-Seok] Ajou Univ, Sch Med, Dept Family Practice & Community Hlth, Suwon 441749, South Korea.
C3 Pochon Cha University; Konkuk University; Ajou University
RP Joo, NS (corresponding author), Ajou Univ, Sch Med, Dept Family Practice & Community Hlth, Suwon 441749, South Korea.
EM jchcmc@hanmail.net
OI Yeum, Kyung-Jin/0000-0002-7846-0272
FU Kuhnil Pharmacy, Korea
FX Contract grant sponsor: Kuhnil Pharmacy, Korea
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NR 36
TC 29
Z9 33
U1 0
U2 8
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1520-4081
EI 1522-7278
J9 ENVIRON TOXICOL
JI Environ. Toxicol.
PD JAN
PY 2015
VL 30
IS 1
BP 101
EP 108
DI 10.1002/tox.21899
PG 8
WC Environmental Sciences; Toxicology; Water Resources
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Toxicology; Water Resources
GA AX2LI
UT WOS:000346775000010
PM 23929718
OA hybrid
DA 2025-06-11
ER

PT J
AU Rosso, LG
   Lhomme, M
   Meroño, T
   Sorroche, P
   Catoggio, L
   Soriano, E
   Saucedo, C
   Malah, V
   Dauteuille, C
   Boero, L
   Lesnik, P
   Robillard, P
   Chapman, MJ
   Brites, F
   Kontush, A
AF Gomez Rosso, Leonardo
   Lhomme, Marie
   Merono, Tomas
   Sorroche, Patricia
   Catoggio, Luis
   Soriano, Enrique
   Saucedo, Carla
   Malah, Veronica
   Dauteuille, Carolane
   Boero, Laura
   Lesnik, Philippe
   Robillard, Paul
   Chapman, M. John
   Brites, Fernando
   Kontush, Anatol
TI Altered lipidome and antioxidative activity of small, dense HDL in
   normolipidemic rheumatoid arthritis: Relevance of inflammation
SO ATHEROSCLEROSIS
LA English
DT Article
DE Rheumatoid arthritis; Inflammation; HDL; Antioxidative activity;
   Dysfunction; Cardiovascular disease
ID SYSTEMIC-LUPUS-ERYTHEMATOSUS; ELEVATED OXIDATIVE STRESS; C-REACTIVE
   PROTEIN; CELLULAR CHOLESTEROL EFFLUX; CARDIOVASCULAR RISK;
   PHOSPHOLIPASE-D; HUMAN-SERUM; METABOLIC SYNDROME; APOA-I; PARTICLES
AB Objective: High-density lipoprotein (HDL) particles exert potent antiatherogenic activities, including antioxidative actions, which are relevant to attenuation of atherosclerosis progression. Such activities are enriched in small, dense HDL and can be compromised under conditions of chronic inflammation like rheumatoid arthritis (RA). However, structure function relationships of HDL largely remain indeterminate. Methods: The relationships between HDL structure and function were evaluated in normolipidemic patients with active RA (DA528 > 3.2; n = 12) and in normolipidemic age-matched controls (n = 10). Small, dense HDL3b and 3c particles were isolated from plasma or serum by density gradient ultracentrifugation and their physicochemical characteristics, lipidome (by LC/MS/MS) and antioxidative function (as protection of normolipidemic LDL from free radical-induced oxidation) were evaluated. Results: As expected, active RA patients featured significantly elevated plasma levels of high-sensitivity C-reactive protein (hsCRP; p <0.001) and serum amyloid A (SAA; p < 0.01) relative to controls. Antioxidative activity and weight % chemical composition of small, dense HDL did not differ between RA patients and controls (p > 0.05), whereas HDL phosphosphingolipidome was significantly altered in RA. Subgroup analyses revealed that RA patients featuring high levels of inflammation (hsCRP>10 mg/l) possessed small, dense HDL with reduced antioxidative activities (p < 0.01). Furthermore, antioxidative activity of HDL was inversely correlated with plasma hsCRP (p < 0.01). Conclusions: These data revealed that (i) despite normolipidemic state, the lipidome of small, dense HDL was altered in RA and (ii) high levels of inflammation can be responsible for the functional deficiency of small, dense HDL in RA. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
C1 [Gomez Rosso, Leonardo; Lhomme, Marie; Dauteuille, Carolane; Lesnik, Philippe; Robillard, Paul; Chapman, M. John; Kontush, Anatol] Natl Inst Hlth & Med Res INSERM, UMR ICAN 1166, F-75013 Paris, France.
   [Gomez Rosso, Leonardo; Merono, Tomas; Boero, Laura; Brites, Fernando] Univ Buenos Aires, CONICET, INFIBIOC, Lab Lipids & Lipoprot,Sch Pharm & Biochem, Buenos Aires, DF, Argentina.
   [Lhomme, Marie; Dauteuille, Carolane; Lesnik, Philippe; Robillard, Paul; Chapman, M. John; Kontush, Anatol] Univ Paris 06, F-75013 Paris, France.
   [Lhomme, Marie; Dauteuille, Carolane; Lesnik, Philippe; Robillard, Paul; Chapman, M. John; Kontush, Anatol] Grp Hosp Pitie Salpetriere, AP HP, F-75013 Paris, France.
   [Lhomme, Marie] ICAN, Paris, France.
   [Sorroche, Patricia; Catoggio, Luis; Soriano, Enrique; Saucedo, Carla] Escuela Med Hosp Italiano Buenos Aires, Inst Univ, Hosp Italiano Buenos Aires, Rheumatol Sect,Med Serv, Buenos Aires, DF, Argentina.
   [Sorroche, Patricia; Catoggio, Luis; Soriano, Enrique; Saucedo, Carla] Escuela Med Hosp Italiano Buenos Aires, Inst Univ, Hosp Italiano Buenos Aires, Cent Lab, Buenos Aires, DF, Argentina.
   [Malah, Veronica] Hosp Clin Jose San Martin, Arthrit Serv, Buenos Aires, DF, Argentina.
C3 Sorbonne Universite; Institut National de la Sante et de la Recherche
   Medicale (Inserm); University of Buenos Aires; Consejo Nacional de
   Investigaciones Cientificas y Tecnicas (CONICET); Sorbonne Universite;
   Assistance Publique Hopitaux Paris (APHP); Hopital Universitaire
   Pitie-Salpetriere - APHP; Sorbonne Universite; Institut National de la
   Sante et de la Recherche Medicale (Inserm); Sorbonne Universite;
   Hospital Italiano de Buenos Aires; University of Buenos Aires;
   University of Buenos Aires Hospital; University of Buenos Aires;
   University of Buenos Aires Hospital; Hospital Italiano de Buenos Aires;
   University of Buenos Aires; University of Buenos Aires Hospital;
   Hospital de Clinicas Jose de San Martin
RP Kontush, A (corresponding author), Hop La Pitie Salpetriere, INSERM UMR ICAN 1166, Pavillon Benjamin Delessert,83 Blvd Hop, F-75651 Paris 13, France.
EM mulag@hotmail.com; m.lhomme@fondation-ican.com; tomasmero@yahoo.com.ar;
   patricia.sorroche@hospitalitaliano.org.ar;
   luis.catoggio@hospitalitaliano.org.ar;
   enrique.soriano@hospitalitaliano.org.ar;
   carla.saucedo@hospitalitaliano.org.ar; vmalah@speedy.com.ar;
   carolane.dauteuille@inserm.fr; laura.boero@hotmail.com;
   philippe.lesnik@upmc.fr; junkdna@riseup.net; john.chapman@upmc.fr;
   fdbrites@hotmail.com; anatol.kontush@upmc.fr
RI Soriano, Enrique/AAN-4206-2020; Evelson, Pablo/J-1245-2014; Kontush,
   Anatol/J-2198-2016; Lesnik, Philippe/AAD-7393-2020; Rosso,
   Leonardo/E-1581-2011; Catoggio, Luis/Y-9781-2019; chapman,
   john/Y-2742-2019; Merono, Tomas/T-4060-2017
OI Kontush, Anatol/0000-0002-9008-7335; Soriano, Enrique
   Roberto/0000-0003-3143-1084; Gomez Rosso, Leonardo/0000-0002-4196-2391;
   LHOMME, MARIE/0000-0002-6335-4506; Merono, Tomas/0000-0002-2673-3494
FU CONICET (Buenos Aires, Argentina); National Institute for Health and
   Medical Research (INSERM, Paris, France); CODDIM Ile-de-France;
   University of Pierre and Marie Curie (UPMC); Fondation de France and the
   Fondation pour la Recherche Medicale (Paris, France); University of
   Buenos Aires (UBACyT) [CB23]; Craveni Foundation and from CONICET [PIP
   516]; Assistance Publique-HOpitaux de Paris/INSERM (France)
FX These studies were primarily supported by a collaborative grant from
   CONICET (Buenos Aires, Argentina) and National Institute for Health and
   Medical Research (INSERM, Paris, France). We gratefully acknowledge
   further support from the CODDIM Ile-de-France, University of Pierre and
   Marie Curie (UPMC), the Fondation de France and the Fondation pour la
   Recherche Medicale (Paris, France), University of Buenos Aires (UBACyT
   CB23), Craveni Foundation and from CONICET (PIP 516). AK. acknowledges
   the award of a Contrat d'Interface from Assistance Publique-HOpitaux de
   Paris/INSERM (France).
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NR 50
TC 53
Z9 53
U1 0
U2 13
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0021-9150
EI 1879-1484
J9 ATHEROSCLEROSIS
JI Atherosclerosis
PD DEC
PY 2014
VL 237
IS 2
BP 652
EP 660
DI 10.1016/j.atherosclerosis.2014.09.034
PG 9
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA AW1RG
UT WOS:000346066600070
PM 25463101
OA Green Published
DA 2025-06-11
ER

PT J
AU Voloshin, I
   Hahn-Obercyger, M
   Anavi, S
   Tirosh, O
AF Voloshin, Irina
   Hahn-Obercyger, Michal
   Anavi, Sarit
   Tirosh, Oren
TI arginine conjugates of bile acids-a possible treatment for non-alcoholic
   fatty liver disease
SO LIPIDS IN HEALTH AND DISEASE
LA English
DT Article
DE Liver damage; Steatosis; Over-nutrition; Obesity; Metabolic syndrome
ID OXIDATIVE STRESS; RISK-FACTORS; STEATOHEPATITIS; MICE; HEPATOCYTES;
   METABOLISM; ACTIVATION; SECRETION; DONORS; DIET
AB Background: Non-alcoholic fatty liver disease (NAFLD) is a continuum of diseases that include simple steatosis and non-alcoholic steatohepatitis (NASH) ultimately leading to cirrhosis, hepatocellular carcinoma and end stage liver failure. Currently there is no approved treatment for NASH. It is known that bile acids not only have physiological roles in lipid digestion but also have strong hormonal properties. We have synthesized a novel chenodeoxycholyl-arginine ethyl ester conjugate (CDCArg) for the treatment of NAFLD.
   Methods: Chemical synthesis of CDCArg was performed. Experiments for prevention and treatment of NAFLD were carried out on C57BL/6 J male mice that were treated with high fat diet (HFD, 60% calories from fat). CDCArg or cholic acid bile acids were admixture into the diets. Food consumption, weight gain, liver histology, intraperitoneal glucose tolerance test, biochemical analysis and blood parameters were assessed at the end of the experiment after 5 weeks of diet (prevention study) or after 14 weeks of diet (treatment study). In the treatment study CDCArg was admixture into the diet at weeks 10-14.
   Results: In comparison to HFD treated mice, mice treated with HFD supplemented with CDCArg, showed reduced liver steatosis, reduced body weight and decreased testicular fat and liver tissue mass. Blood glucose, cholesterol, insulin and leptin levels were also lower in this group. No evidence of toxicity of CDCArg was recorded. In fact, liver injury, as evaluated using plasma hepatic enzyme levels, was low in mice treated with HFD and CDCArg when compared to mice treated with HFD and cholic acid.
   Conclusion: CDCArg supplementation protected the liver against HFD-induced NAFLD without any toxic effects. These results indicate that basic amino acids e. g., L-arginine and bile acids conjugates may be a potential therapy for NAFLD.
C1 [Voloshin, Irina; Hahn-Obercyger, Michal; Anavi, Sarit; Tirosh, Oren] Hebrew Univ Jerusalem, Inst Biochem Food Sci & Nutr, Robert H Smith Fac Agr Food & Environm, IL-76100 Rehovot, Israel.
C3 Hebrew University of Jerusalem
RP Tirosh, O (corresponding author), Hebrew Univ Jerusalem, Inst Biochem Food Sci & Nutr, Robert H Smith Fac Agr Food & Environm, POB 12, IL-76100 Rehovot, Israel.
EM oren.tirosh@mail.huji.ac.il
FU Baby seed; Yissum Research Development Company of the Hebrew University
   of Jerusalem Ltd.
FX The research was supported by a Baby seed grant to O.T. of Yissum
   Research Development Company of the Hebrew University of Jerusalem Ltd.
   with collaboration of OneDay - Biotech and Pharma Ltd.
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NR 31
TC 18
Z9 20
U1 1
U2 14
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1476-511X
J9 LIPIDS HEALTH DIS
JI Lipids Health Dis.
PD APR 22
PY 2014
VL 13
AR 69
DI 10.1186/1476-511X-13-69
PG 11
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA AG3TJ
UT WOS:000335342300001
PM 24750587
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Gustafsson, PE
   San Sebastian, M
   Janlert, U
   Theorell, T
   Westerlund, H
   Hammarström, A
AF Gustafsson, Per E.
   San Sebastian, Miguel
   Janlert, Urban
   Theorell, Tores
   Westerlund, Hugo
   Hammarstrom, Anne
TI Residential Selection across the Life Course: Adolescent Contextual and
   Individual Determinants of Neighborhood Disadvantage in Mid-Adulthood
SO PLOS ONE
LA English
DT Article
ID CORONARY-HEART-DISEASE; SOCIOECONOMIC DISADVANTAGE; MULTILEVEL ANALYSIS;
   METABOLIC SYNDROME; PHYSICAL-ACTIVITY; ALLOSTATIC LOAD; CAUSAL
   INFERENCE; CHRONIC STRESS; AGED WOMEN; MORTALITY
AB Background: Numerous cross-sectional studies have examined neighborhood effects on health. Residential selection in adulthood has been stressed as an important cause of selection bias but has received little empirical attention, particularly its determinants from the earlier life course. The present study aims to examine whether neighborhood, family, school, health behaviors and health in adolescence are related to socioeconomic disadvantage of one's neighborhood of residence in adulthood.
   Methods: Based on the prospective Northern Swedish Cohort (analytical N = 971, 90.6% retention rate), information was collected at age 16 years concerning family circumstances, school adjustment, health behaviors and mental and physical health. Neighborhood register data was linked to the cohort and used to operationalize aggregated measures of neighborhood disadvantage (ND) at age 16 and 42. Data was analyzed with linear mixed models, with ND in adulthood regressed on adolescent predictors and neighborhood of residence in adolescence as the level-2 unit.
   Results: Neighborhood disadvantage in adulthood was clustered by neighborhood of residence in adolescence (ICC = 8.6%). The clustering was completely explained by ND in adolescence. Of the adolescent predictors, ND (b =.14 (95% credible interval =.07-.22)), final school marks (b =-.18 (-.26--.10)), socioeconomic disadvantage (b =.07 (.01-.14)), and, with borderline significance, school peer problems (b =-.07 (-.00-.13)), were independently related to adulthood ND in the final adjusted model. In sex-stratified analyses, the most important predictors were school marks (b =-.21 (-.32--.09)) in women, and neighborhood of residence (ICC = 15.5%) and ND (b =.20 (.09-.31)) in men.
   Conclusions: These findings show that factors from adolescence - which also may impact on adult health - could influence the neighborhood context in which one will live in adulthood. This indicates that residential selection bias in neighborhood effects on health research may have its sources in early life.
C1 [Gustafsson, Per E.; San Sebastian, Miguel; Janlert, Urban; Hammarstrom, Anne] Umea Univ, Dept Publ Hlth & Clin Med, Umea, Sweden.
   [Theorell, Tores; Westerlund, Hugo] Stockholm Univ, Stress Res Inst, S-10691 Stockholm, Sweden.
C3 Umea University; Stockholm University
RP Gustafsson, PE (corresponding author), Umea Univ, Dept Publ Hlth & Clin Med, Umea, Sweden.
EM Per.E.Gustafsson@umu.se
RI Gustafsson, Per/AAY-5068-2021; Hammarström, Anne/HNI-3080-2023;
   Westerlund, Hugo/IZP-7925-2023
OI Theorell, Tores/0000-0003-1956-7931; San Sebastian,
   Miguel/0000-0001-7234-3510; Gustafsson, Per E/0000-0002-3972-5362;
   Hammarstrom, Anne/0000-0002-4095-7961
FU Swedish Research Council Formas [259-2012-37]; Umea University Young
   Researcher Award [223-514-09]
FX The study was supported by The Swedish Research Council Formas
   (www.formas.se, grant# 259-2012-37) and by Umea University (www.umu.se,
   Young Researcher Award, grant# 223-514-09). The funders had no role in
   study design, data collection and analysis, decision to publish, or
   preparation of the manuscript.
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NR 50
TC 17
Z9 19
U1 1
U2 26
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD NOV 21
PY 2013
VL 8
IS 11
AR e80241
DI 10.1371/journal.pone.0080241
PG 11
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Science & Technology - Other Topics
GA 259PW
UT WOS:000327539800065
PM 24278263
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Srivastava, RAK
   Pinkosky, SL
   Filippov, S
   Hanselman, JC
   Cramer, CT
   Newton, RS
AF Srivastava, Rai Ajit K.
   Pinkosky, Stephen L.
   Filippov, Sergey
   Hanselman, Jeffrey C.
   Cramer, Clay T.
   Newton, Roger S.
TI AMP-activated protein kinase: an emerging drug target to regulate
   imbalances in lipid and carbohydrate metabolism to treat
   cardio-metabolic diseases
SO JOURNAL OF LIPID RESEARCH
LA English
DT Review
DE atherosclerosis; cholesterol; diabetes; drug therapy; dyslipidemias;
   fatty acid; inflammation; obesity; hepatic steatosis
ID FATTY-ACID OXIDATION; ENDOPLASMIC-RETICULUM STRESS; ACETYL-COA
   CARBOXYLASE; NF-KAPPA-B; ELEMENT-BINDING PROTEIN; MUSCLE GLUCOSE-UPTAKE;
   HUMAN SKELETAL-MUSCLE; STIMULATED INSULIN-SECRETION; RESPIRATORY
   COMPLEX-I; ALPHA-LIPOIC ACID
AB The adenosine monophosphate-activated protein kinase (AMPK) is a metabolic sensor of energy metabolism at the cellular as well as whole-body level. It is activated by low energy status that triggers a switch from ATP-consuming anabolic pathways to ATP-producing catabolic pathways. AMPK is involved in a wide range of biological activities that normalizes lipid, glucose, and energy imbalances. These pathways are dysregulated in patients with metabolic syndrome (MetS), which represents a clustering of major cardiovascular risk factors including diabetes, lipid abnormalities, and energy imbalances. Clearly, there is an unmet medical need to find a molecule to treat alarming number of patients with MetS. AMPK, with multifaceted activities in various tissues, has emerged as an attractive drug target to manage lipid and glucose abnormalities and maintain energy homeostasis. A number of AMPK activators have been tested in preclinical models, but many of them have yet to reach to the clinic. This review focuses on the structure-function and role of AMPK in lipid, carbohydrate, and energy metabolism. The mode of action of AMPK activators, mechanism of anti-inflammatory activities, and preclinical and clinical findings as well as future prospects of AMPK as a drug target in treating cardio-metabolic disease are discussed.-Srivastava, R. A. K., S. L. Pinkosky, S. Filippov, J. C. Hanselman, C. T. Cramer, and R. S. Newton. AMP-activated protein kinase: an emerging drug target to regulate imbalances in lipid and carbohydrate metabolism to treat cardio-metabolic diseases. J. Lipid Res. 2012. 53: 2490-2514.
C1 [Srivastava, Rai Ajit K.; Pinkosky, Stephen L.; Filippov, Sergey; Hanselman, Jeffrey C.; Cramer, Clay T.; Newton, Roger S.] Esper Therapeut Inc, Plymouth, MI 48170 USA.
RP Srivastava, RAK (corresponding author), Esper Therapeut Inc, Plymouth, MI 48170 USA.
EM ajitsriva@gmail.com; rnewton@esperion.com
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NR 303
TC 240
Z9 255
U1 1
U2 65
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0022-2275
EI 1539-7262
J9 J LIPID RES
JI J. Lipid Res.
PD DEC
PY 2012
VL 53
IS 12
BP 2490
EP 2514
DI 10.1194/jlr.R025882
PG 25
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 034XA
UT WOS:000310905000002
PM 22798688
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Bose, T
   Voruganti, VS
   Tejero, ME
   Proffitt, JM
   Cox, LA
   VandeBerg, JL
   Mahaney, MC
   Rogers, J
   Freeland-Graves, JH
   Cole, SA
   Comuzzie, AG
AF Bose, Tanushree
   Voruganti, V. Saroja
   Tejero, M. Elizabeth
   Proffitt, J. Michael
   Cox, Laura A.
   VandeBerg, John L.
   Mahaney, Michael C.
   Rogers, Jeffrey
   Freeland-Graves, Jeanne H.
   Cole, Shelley A.
   Comuzzie, Anthony G.
TI Quantitative Loci Regulating Plasma Levels of γ Glutamyl Transferase and
   Albumin and Their Genetic Correlations with Cardiovascular Risk Factors
SO EXPERIMENTAL BIOLOGY AND MEDICINE
LA English
DT Article
DE NAFLD; obesity; genome scan; atherosclerosis; oxidative stress
ID NONALCOHOLIC FATTY LIVER; PAPIO-HAMADRYAS GENOME; METABOLIC SYNDROME;
   INSULIN-RESISTANCE; DISEASE MORTALITY; LINKAGE ANALYSIS; AUSTRIAN
   ADULTS; FUNCTION TESTS; SERUM-ALBUMIN; BABOONS
AB gamma Glutamyl transferase (GGT) and albumin (ALB) are two markers of liver function. These two proteins have been associated with non-alcoholic fatty liver disease and cardiovascular disease. The objectives of this study were to explore the genetic factors that influence variation in the plasma levels of GGT and ALB and to evaluate their genetic correlations with cardiovascular risk factors. Baboons from the Southwest National Primate Research Center at the Southwest Foundation for Biomedical Research, San Antonio, TX, were used as an animal model. The baboons were fed a standard monkey chow diet ad libitum. Fasting plasma concentrations of GGT, ALB, triglycerides, total cholesterol and LDL cholesterol were measured in 350 pedigreed adult baboons by standard assay procedures. A maximum likelihood-based variance decomposition approach implemented in the computer program SOLAR was used to conduct genetic analyses. The heritabilities of GGT (h(2) = 0.55; P < 0.0001) and ALB (h(2) = 0.42; P < 0.01) were significant. No statistically significant associations were found between GGT and the cardiovascular-related phenotypes. Genetic correlations between ALB and total cholesterol, LDL cholesterol and triglycerides were significant. A QTL (LOD = 2.8) for GGT plasma levels was identified on the baboon homologue of human chromosome 22 between markers D22S304 and D22S280. A QTL (LOD = 2.3) near marker D10S1432 was detected on the baboon homologue of human chromosome 10 for ALB. These results imply that variations in the plasma levels of GGT and ALB are under significant genetic regulation and that a common genetic component influences ALB and cardiovascular risk factor phenotypes. Exp Biol Med 234:1519-1524, 2009
C1 [Bose, Tanushree] Calif Polytech State Univ San Luis Obispo, Dept Food Sci & Nutr, San Luis Obispo, CA 93407 USA.
   [Bose, Tanushree; Freeland-Graves, Jeanne H.] Univ Texas Austin, Dept Human Ecol, Div Nutr Sci, Austin, TX 78712 USA.
   [Voruganti, V. Saroja; Tejero, M. Elizabeth; Proffitt, J. Michael; Cox, Laura A.; VandeBerg, John L.; Mahaney, Michael C.; Rogers, Jeffrey; Cole, Shelley A.; Comuzzie, Anthony G.] SW Fdn Biomed Res, Dept Genet, San Antonio, TX 78245 USA.
   [Cox, Laura A.; VandeBerg, John L.; Mahaney, Michael C.; Rogers, Jeffrey; Comuzzie, Anthony G.] SW Natl Primate Res Ctr, San Antonio, TX 78245 USA.
C3 California State University System; California Polytechnic State
   University San Luis Obispo; University of Texas System; University of
   Texas Austin; Texas Biomedical Research Institute; Texas Biomedical
   Research Institute
RP Bose, T (corresponding author), Calif Polytech State Univ San Luis Obispo, Dept Food Sci & Nutr, 1 Grand Ave, San Luis Obispo, CA 93407 USA.
EM tbose@calpoly.edu
RI Tejero, Maria/MBV-3355-2025
OI Cox, Laura/0000-0002-8836-3783
FU NIH [C06 RR014578, C06 RR013556, C06 RR015456, C06 RR017515, PO1
   HL028972, P51 RR013986]; Kronkosky Foundation
FX This investigation was conducted in part in facilities constructed with
   support from the Research Facilities improvement Program under grant
   numbers C06 RR014578, C06 RR013556, C06 RR015456. C06 RR017515, and with
   support from NIH grants PO1 HL028972, and P51 RR013986 as well as with
   research Support from the Kronkosky Foundatio.
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NR 43
TC 5
Z9 5
U1 0
U2 5
PU SOC EXPERIMENTAL BIOLOGY MEDICINE
PI MAYWOOD
PA 195 WEST SPRING VALLEY AVE, MAYWOOD, NJ 07607-1727 USA
SN 1535-3702
J9 EXP BIOL MED
JI Exp. Biol. Med.
PD DEC
PY 2009
VL 234
IS 12
BP 1519
EP 1524
DI 10.3181/0903-RM-115
PG 6
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 536BY
UT WOS:000273018400014
PM 19934372
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Wirth, JP
   Zeng, W
   Petry, N
   Rohner, F
   Glenn, S
   Donkor, WES
   Wegmüller, R
   Boy, E
   Lividini, K
AF Wirth, James P.
   Zeng, Wu
   Petry, Nicolai
   Rohner, Fabian
   Glenn, Scott
   Donkor, William E. S.
   Wegmuller, Rita
   Boy, Erick
   Lividini, Keith
TI The global burden of high fasting plasma glucose associated with zinc
   deficiency: Results of a systematic review and meta- analysis
SO PLOS GLOBAL PUBLIC HEALTH
LA English
DT Article
ID METABOLIC SYNDROME; DISEASE MORTALITY; NATIONAL-HEALTH; SUPPLEMENTATION;
   NUTRITION; SELENIUM; TRENDS; FORTIFICATION; INFLAMMATION; COVERAGE
AB Non-communicable diseases (NCDs) account for the largest share of the global disease burden, and increasing evidence shows that zinc deficiency (ZD) contributes to NCDs by inducing oxidative stress, insulin resistance, and impaired lipid metabolism. A systematic review and meta-analysis was conducted to determine whether ZD was associated with fasting plasma glucose (FPG), a key risk factor for NCDs. A random effects meta-analysis was conducted to determine the strength of the association in the form of an odds ratio (OR) and subsequently the population attributable risk (PAR) with population prevalences of high FPG. The disease burden from high FPG attributable to ZD was expressed as disability adjusted life years (DALYS). Data from seven studies were obtained as part of the systematic review. The meta-analysis shows a significant (p<0.01) inverse relationship between ZD and high FPG (OR = 2.34; 95% CI: 1.16, 4.72). Globally, the PAR of ZD's contribution to high FPG is 6.7%, with approximately 8.2 million high FPG DALYs attributable to ZD. Cardiovascular diseases, diabetes, and chronic kidney diseases account for more than 90% of the total DALYs. Total DALYs attributable to ZD are largest in the "Southeast Asia, East Asia, and Oceania" and "High Income" Super Regions. While the disease burden is highest among populous countries (e.g., China, India, USA), the population-standardized DALYs are highest among island nations, particularly island nations in the South Pacific and Caribbean. While ZD accounts for a small share of the high FPG disease burden, the total number of DALYs far surpasses other estimates of the disease burden attributable to ZD, which focus on diarrheal diseases in childhood. Zinc interventions are urgently needed to help address the increasing disease burden from NCDs, and the double burden of malnutrition.
C1 [Wirth, James P.; Zeng, Wu; Petry, Nicolai; Rohner, Fabian; Donkor, William E. S.; Wegmuller, Rita] GroundWork, Flasch, Switzerland.
   [Zeng, Wu] Georgetown Univ, Sch Hlth, Washington, DC USA.
   [Glenn, Scott] Inst Hlth Metr & Evaluat, Seattle, WA 98121 USA.
   [Boy, Erick; Lividini, Keith] Int Food Policy Res Inst IFPRI, Res Delivery & Impact Div, Washington, DC USA.
C3 Georgetown University; Institute for Health Metrics & Evaluation; CGIAR;
   International Food Policy Research Institute (IFPRI)
RP Wirth, JP (corresponding author), GroundWork, Flasch, Switzerland.
EM james@groundworkhealth.org
RI Rohner, Fabian/I-5088-2019; Boy, Erick/HDO-0821-2022; Zeng,
   Wu/ABC-1930-2022
OI Boy, Erick/0000-0002-0271-1725; Lividini, Keith/0000-0002-5037-193X; BOY
   LAZONI, ERICK MARCO/0000-0003-2379-1346; Rohner,
   Fabian/0000-0003-0579-6952; Zeng, Wu/0000-0002-3473-3638
FU HarvestPlus to GroundWork [2020H8406]; HarvestPlus; Bill & Melinda Gates
   Foundation [INV-002975]; Bill and Melinda Gates Foundation [INV-002975]
   Funding Source: Bill and Melinda Gates Foundation
FX Financial support for this study was provided by HarvestPlus
   (www.HarvestPlus.org) , a global program working to develop and promote
   biofortified food crops that are rich in vitamins and minerals needed
   for good health. The views expressed do not necessarily reflect those of
   HarvestPlus. Funding for this study was provided by HarvestPlus to
   GroundWork (Agreement #2020H8406.GRO) . HarvestPlus provided these funds
   under an agreement with the Bill & Melinda Gates Foundation (BMGF;
   INV-002975 to EB) ; BMGF as the funder had no role in study design, data
   collection and analysis, decision to publish, or preparation of the
   manuscript.
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NR 64
TC 3
Z9 3
U1 0
U2 0
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
EI 2767-3375
J9 PLOS GLOB PUBL HLTH
JI PLOS Glob. Public Health
PD MAR 13
PY 2023
VL 3
IS 3
AR e0001353
DI 10.1371/journal.pgph.0001353
PG 22
WC Public, Environmental & Occupational Health
WE Emerging Sources Citation Index (ESCI)
SC Public, Environmental & Occupational Health
GA W6E2X
UT WOS:001419477000001
PM 36963036
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Song, FH
   Dai, W
   Li, HH
   Zhang, XW
   Xu, XL
   Ma, LL
   Wang, L
AF Song, Fuhang
   Dai, Wei
   Li, Honghua
   Zhang, Xinwan
   Xu, Xiuli
   Ma, Linlin
   Wang, Long
TI Characterization of Hypolipidemic Phenol Analogues from Fermented Tea by
   Eurotium cristatum
SO FOODS
LA English
DT Article
DE Fuzhuan brick tea; hydroxybenzaldehyde derivatives; Eurotium cristatum;
   hypolipidemic; fatty liver; C57BL; 6N mice
ID METABOLIC SYNDROME; INTESTINAL MICROBIOTA; FUNCTIONAL FOODS; OXIDATIVE
   STRESS; IN-VITRO; BRICK; DISEASE; OBESITY; HEALTH; FUNGI
AB Fuzhuan brick tea (FBT), a type of black tea, is a traditional beverage in China, especially popular among frontier ethnic groups. FBT is well-known for its health benefits, such as hypoglycemic, anti-hypertensive, anti-inflammatory, diuretic, and detoxification effects. Nevertheless, the underlying mechanisms on the molecular level are still elusive and the key compounds responsible for the health benefits are unidentified. Previous studies have mainly focused on functional studies of the water extract. However, FBT is typically cooked with butter or milk. Therefore, we hypothesized that some lipophilic components in FBT, which can be absorbed through the co-consumption of butter or milk, may play an important role in the health benefits. The present study aimed to investigate whether the liposoluble extract of FBT alleviates symptoms related to metabolic diseases and to identify the active compounds involved. By comparing the high-performance liquid chromatography (HPLC) profiles of water, milk and hexane extract, some low polarity peaks were observed in the milk and hexane extracts. Furthermore, the hexane extract treatment alleviated body weight gain, serum total cholesterol and triglyceride levels, and inhibited the accumulation of hepatic fat granules in a high-fat diet (HFD)-induced C57BL/6N mouse model. In order to identify the key functional lipophilic compounds in FBT, the hexane extract of FBT was subjected to chemical characterization. Four phenol analogs were characterized, namely, isodihydroauroglaucin (1), dihydroauroglaucin (2), tetrahydroauroglaucin (3), and flavoglaucin (4). Compounds 1 and 4 reduced the levels of total cholesterol and triglyceride in vivo. Both compounds also inhibited the high-fat diet-induced body weight gain and accumulation of fat granules in the liver of C57BL/6N mice. Isodihydroauroglaucin and flavoglaucin have therefore been identified as bioactive ingredients that contribute to the health benefits of FBT.
C1 [Song, Fuhang; Dai, Wei; Li, Honghua] Beijing Technol & Business Univ, Sch Light Ind, Beijing 100048, Peoples R China.
   [Zhang, Xinwan; Xu, Xiuli] China Univ Geosci, Sch Ocean Sci, Beijing 100083, Peoples R China.
   [Ma, Linlin] Griffith Univ, Sch Environm & Sci, Griffith Inst Drug Discovery, Brisbane, Qld 4111, Australia.
   [Wang, Long] Chinese Acad Sci, Inst Microbiol, Key Lab Mycol, Beijing 100101, Peoples R China.
C3 Beijing Technology & Business University; China University of
   Geosciences; Griffith University; Chinese Academy of Sciences; Institute
   of Microbiology, CAS
RP Song, FH (corresponding author), Beijing Technol & Business Univ, Sch Light Ind, Beijing 100048, Peoples R China.; Xu, XL (corresponding author), China Univ Geosci, Sch Ocean Sci, Beijing 100083, Peoples R China.
EM songfuhang@btbu.edu.cn; xuxl@cugb.edu.cn
RI dai, wei/GRR-8868-2022; LINLIN, MA/GZM-6143-2022
OI Ma, Linlin/0000-0002-4716-5158; , Fuhang Song/0000-0002-9162-3355
FU Research Foundation for Advanced Talents of Beijing Technology and
   Business University [19008021176]; Key Lab of Marine Bioactive Substance
   and Modern Analytical Technique, SOA [MBSMAT-2019-06]
FX This work was funded by grants from the Research Foundation for Advanced
   Talents of Beijing Technology and Business University (19008021176), and
   the Key Lab of Marine Bioactive Substance and Modern Analytical
   Technique, SOA (MBSMAT-2019-06).
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NR 67
TC 2
Z9 2
U1 8
U2 55
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2304-8158
J9 FOODS
JI Foods
PD JAN
PY 2023
VL 12
IS 1
AR 49
DI 10.3390/foods12010049
PG 13
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA 7R1XB
UT WOS:000909870300001
PM 36613264
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Bhori, M
   Rastogi, V
   Tungare, K
   Marar, T
AF Bhori, Mustansir
   Rastogi, Varuni
   Tungare, Kanchanlata
   Marar, Thankamani
TI A review on interplay between obesity, lipoprotein profile and
   nutrigenetics with selected candidate marker genes of type 2 diabetes
   mellitus
SO MOLECULAR BIOLOGY REPORTS
LA English
DT Review
DE Type 2 diabetes mellitus; CAPN10; FABP2; Obesity; Lipoprotein profile;
   Nutrigenetics
ID ACID-BINDING PROTEIN-2; BODY-MASS INDEX; ENDOPLASMIC-RETICULUM STRESS;
   ENPP1 K121Q POLYMORPHISM; FABP2 A54T POLYMORPHISM; BETA-CELL FUNCTION;
   INSULIN-RESISTANCE; ECTOPIC FAT; WAIST CIRCUMFERENCE; METABOLIC SYNDROME
AB Background Type 2 diabetes mellitus, a rapidly growing epidemic, and its frequently related complications demand global attention. The two factors commonly attributed to the epidemic are genetic factors and environmental factors. Studies indicate that the genetic makeup at an individual level and the environmental aspects influence the occurrence of the disease. However, there is insufficiency in understanding the mechanisms through which the gene mutations and environmental components individually lead to T2DM. Also, discrepancies have often been noted in the association of gene variants and type 2 diabetes when the gene factor is examined as a sole attribute to the disease. Study In this review initially, we have focused on the proposed ways through which CAPN10, FABP2, GLUT2, TCF7L2, and ENPP1 variants lead to T2DM along with the inconsistencies observed in the gene-disease association. The article also emphasizes on obesity, lipoprotein profile, and nutrition as environmental factors and how they lead to T2DM. Finally, the main objective is explored, the environment-gene-disease association i.e. the influence of each environmental factor on the aforementioned specific gene-T2DM relationship to understand if the disease-causing capability of the gene variants is exacerbated by environmental influences. Conclusion We found that environmental factors may influence the gene-disease relationship. Reciprocally, the genetic factors may alter the environment-disease relationship. To precisely conclude that the two factors act synergistically to lead to T2DM, more attention has to be paid to the combined influence of the genetic variants and environmental factors on T2DM occurrence instead of studying the influence of the factors separately.
C1 [Bhori, Mustansir; Rastogi, Varuni; Tungare, Kanchanlata; Marar, Thankamani] DY Patil, Sch Biotechnol & Bioinformat, Navi Mumbai 400614, India.
RP Tungare, K (corresponding author), DY Patil, Sch Biotechnol & Bioinformat, Navi Mumbai 400614, India.
EM skanchan19@gmail.com
RI Marar, Thankamani/GVS-2072-2022; Bhori, Mustansir/JTU-7950-2023;
   Tungare, Dr. Kanchanlata/GVS-0789-2022
OI Tungare, Dr. Kanchanlata/0000-0002-8130-4158
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NR 160
TC 6
Z9 6
U1 1
U2 9
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0301-4851
EI 1573-4978
J9 MOL BIOL REP
JI Mol. Biol. Rep.
PD JAN
PY 2022
VL 49
IS 1
BP 687
EP 703
DI 10.1007/s11033-021-06837-5
EA OCT 2021
PG 17
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA YE3VB
UT WOS:000709275100004
PM 34669123
DA 2025-06-11
ER

PT J
AU Tuccinardi, D
   Di Mauro, A
   Lattanzi, G
   Rossini, G
   Monte, L
   Beato, I
   Spiezia, C
   Bravo, M
   Watanabe, M
   Soare, A
   Kyanvash, S
   Armirotti, A
   Bertozzi, SM
   Gastaldelli, A
   Pedone, C
   Khazrai, YM
   Pozzilli, P
   Manfrini, S
AF Tuccinardi, Dario
   Di Mauro, Antonio
   Lattanzi, Greta
   Rossini, Giovanni
   Monte, Lavinia
   Beato, Ivan
   Spiezia, Chiara
   Bravo, Maria
   Watanabe, Mikiko
   Soare, Andreea
   Kyanvash, Shadi
   Armirotti, Andrea
   Bertozzi, Sine Mandrup
   Gastaldelli, Amalia
   Pedone, Claudio
   Khazrai, Yeganeh Manon
   Pozzilli, Paolo
   Manfrini, Silvia
TI An extra virgin olive oil-enriched chocolate spread positively modulates
   insulin-resistance markers compared with a palm oil-enriched one in
   healthy young adults: A double-blind, cross-over, randomised controlled
   trial
SO DIABETES-METABOLISM RESEARCH AND REVIEWS
LA English
DT Article
DE ceramides; chocolate; diet; extra virgin olive oil; insulin resistance;
   palm oil
ID CARDIOVASCULAR-DISEASE; MEDITERRANEAN DIET; METABOLIC SYNDROME;
   FATTY-ACIDS; OXIDATIVE STRESS; SATURATED FAT; PLASMA; RISK;
   METAANALYSIS; CERAMIDES
AB Aims To investigate if extra virgin olive oil (EVOO) or palm oil enriched chocolate spreads consumption leads to different results in terms of plasma ceramides concentration, glucose and lipid metabolism, inflammatory markers and appetite regulation in young healthy subjects. Methods In a 2-week, double-blind, cross-over, randomised controlled trial, 20 healthy, normal-weight subjects with a mean age of 24.2 years (SD: 1.2), consumed chocolate spread snacks (73% of energy [%E] from fat, 20% from carbohydrates and 7% from proteins), providing 570 Kcal/day added to an isocaloric diet. The chocolate spreads were identical, except for the type of fat: EVOO oil, rich in monounsaturated fatty acids (MUFAs), or palm oil, rich in Saturated Fatty Acids (SFAs). Results EVOO-enriched chocolate spread consumption led to better circulating sphingolipids and glucose profile, with reduced plasma ceramide C16:0, ceramide C16:0/ceramide C22:0-ceramide C24:0 ratio and sphingomyelin C18:0 (P = 0.030, P= 0.032 and P = 0.042, respectively) compared to the palm oil-enriched chocolate spread diet. HOMA-IR and plasma insulin were lower, while the Quicki and the McAuley Index were higher after the EVOO diet compared to the palm oil diet (P = 0.046, P = 0.045, P = 0.018 and P = 0.039 respectively). Subjects maintained a stable weight throughout the study. No major significant changes in total cholesterol, triglycerides, HDL, inflammatory markers, and appetite-regulating hormones/visual analogue scale were observed between the groups. Conclusions Partially replacing SFAs with MUFAs in a chocolate-based snack as part of a short-term isocaloric diet in healthy individuals may limit SFAs detrimental effects on insulin sensitivity and decrease circulating harmful sphingolipids in young adults.
C1 [Tuccinardi, Dario; Di Mauro, Antonio; Lattanzi, Greta; Rossini, Giovanni; Monte, Lavinia; Beato, Ivan; Spiezia, Chiara; Bravo, Maria; Soare, Andreea; Kyanvash, Shadi; Khazrai, Yeganeh Manon; Pozzilli, Paolo; Manfrini, Silvia] Campus Biomed Rome, Unit Endocrinol & Diabet, Dept Med, I-00128 Rome, Italy.
   [Watanabe, Mikiko] Sapienza Univ Rome, Dept Expt Med, Sect Med Pathophysiol Food Sci & Endocrinol, Rome, Italy.
   [Armirotti, Andrea; Bertozzi, Sine Mandrup] Fdn Ist Italiano Tecnol, Analyt Chem Lab, Genoa, Italy.
   [Gastaldelli, Amalia] CNR, Inst Clin Physiol, Pisa, Italy.
   [Pedone, Claudio] Biomed Campus Rome, Unit Geriatr, Dept Med, Rome, Italy.
   [Pozzilli, Paolo] Queen Mary Univ London, Ctr Immunobiol, Barts & London Sch Med & Dent, London, England.
C3 University Campus Bio-Medico - Rome Italy; Sapienza University Rome;
   Istituto Italiano di Tecnologia - IIT; Consiglio Nazionale delle
   Ricerche (CNR); Istituto di Fisiologia Clinica (IFC-CNR); University of
   London; Queen Mary University London
RP Manfrini, S (corresponding author), Campus Biomed Rome, Unit Endocrinol & Diabet, Dept Med, I-00128 Rome, Italy.
EM s.manfrini@unicampus.it
RI watanabe, Mikiko/AAL-6316-2020; Pedone, Claudio/F-9488-2010; Armirotti,
   Andrea/AAB-3284-2019; Tuccinardi, Dario/AAN-9540-2020; Pozzilli,
   Paolo/A-5235-2010; Gastaldelli, Amalia/H-3319-2014
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FX Venchi S.p.A.
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NR 55
TC 12
Z9 13
U1 1
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1520-7552
EI 1520-7560
J9 DIABETES-METAB RES
JI Diabetes-Metab. Res. Rev.
PD FEB
PY 2022
VL 38
IS 2
AR e3492
DI 10.1002/dmrr.3492
EA SEP 2021
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA YR1JN
UT WOS:000698984800001
PM 34435429
OA Green Published
DA 2025-06-11
ER

PT J
AU Yuan, LX
   Ma, ZF
   Zhang, MM
   Qin, LQ
   Yin, XB
   Han, F
AF Yuan, Linxi
   Ma, Zheng Feei
   Zhang, Minming
   Qin, Liqiang
   Yin, Xuebin
   Han, Feng
TI Hair Se Is a Sensitive Biomarker to Monitor the Effects of Se
   Supplementation in Elderly
SO BIOLOGICAL TRACE ELEMENT RESEARCH
LA English
DT Article
DE Elderly; Selenium supplementation; Urine; Serum; Hair; China
ID SELENIUM SUPPLEMENTATION; NUTRITIONAL-STATUS; METABOLIC SYNDROME; CHINA;
   SOIL; BIOFORTIFICATION; PREVENTION; CHILDREN; DISEASES; TRIAL
AB It is rapidly increasing to have selenium (Se) supplementation for urban elderly population in China since they are facing a widespread deficiency daily Se intake. However, until now, there is no low-cost, non-invasive, rapid, and reliable method to monitor the health improvement or risk for elderly Se-supplemented population in China. The present cross-sectional study (229 participants with older than 55 years old) performed in Beijing, China, revealed that the Se concentrations of non-supplementer users (n = 27) were 55 +/- 23 mu g/L in urine, 139.9 +/- 102.3 mu g/L in serum, and 487.6 +/- 158.7 mu g/kg in hair. But a significant increase on hair Se concentrations (615.4 +/- 238.8 mu g/kg) was observed for Se supplementer users (n = 202) (p < 0.05); there were no significant statistical differences in serum and urine between the Se-supplemented (n = 202) and Se non-supplemented groups (n = 27). This indicated the hair Se levels could be a more sensitive biomarker for Se-supplemented elderly population. Participants who consumed Se supplements for 7-12 months had the highest Se status based on hair and serum Se concentrations (p < 0.05). The present study also revealed that most elderly adults in Beijing just need to supplement 50 mu g Se per day to achieve Se plateau status. Furthermore, hair Se levels were positively related with triglycerides/TG levels (p < 0.05) but not body mass index/BMI, total cholesterol/TC, and low-density lipoprotein cholesterol/LDL, implicating Se supplementation for Se sufficiency baseline in elderly population in Beijing likely posed health risk, especially on TG because of excessive Se oxidation stress. An ongoing monitoring of Se status via hair is still warranted to prevent future Se deficiency or excess in China.
C1 [Yuan, Linxi; Ma, Zheng Feei] Xian Jiaotong Liverpool Univ, Dept Hlth & Environm Sci, Suzhou 215123, Jiangsu, Peoples R China.
   [Zhang, Minming; Yin, Xuebin] Univ Sci & Technol China, Suzhou Res Inst, Key Lab Funct Agr, Suzhou 215123, Jiangsu, Peoples R China.
   [Qin, Liqiang] Soochow Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Suzhou 215123, Peoples R China.
   [Han, Feng] Soochow Setek Biotechnol Co Ltd, Res Ctr, Suzhou 215123, Jiangsu, Peoples R China.
C3 Xi'an Jiaotong-Liverpool University; Chinese Academy of Sciences;
   University of Science & Technology of China, CAS; Soochow University -
   China
RP Yuan, LX (corresponding author), Xian Jiaotong Liverpool Univ, Dept Hlth & Environm Sci, Suzhou 215123, Jiangsu, Peoples R China.
EM Linxi.Yuan@xjtlu.edu.cn
RI Yuan, Linxi/Y-9313-2019; Ma, Zheng Feei/B-1225-2015; Zhang,
   Minming/K-8132-2018; han, feng/KBB-3356-2024
OI Yuan, Linxi/0000-0002-1043-8933
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NR 48
TC 6
Z9 6
U1 1
U2 17
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0163-4984
EI 1559-0720
J9 BIOL TRACE ELEM RES
JI Biol. Trace Elem. Res.
PD FEB
PY 2022
VL 200
IS 2
BP 488
EP 496
DI 10.1007/s12011-021-02674-6
EA MAR 2021
PG 9
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA YC9AG
UT WOS:000630289900001
PM 33738684
DA 2025-06-11
ER

PT J
AU Ribó-Coll, M
   Castro-Barquero, S
   Lassale, C
   Sacanella, E
   Ros, E
   Toledo, E
   Sorlí, JV
   Díaz-López, A
   Lapetra, J
   Muñoz-Bravo, C
   Arós, F
   Fiol, M
   Serra-Majem, L
   Pinto, X
   Castañer, O
   Fernández-Lázaro, CI
   Portolés, O
   Babio, N
   Estruch, R
   Hernáez, A
AF Ribo-Coll, Margarita
   Castro-Barquero, Sara
   Lassale, Camille
   Sacanella, Emilio
   Ros, Emilio
   Toledo, Estefania
   Sorli, Jose V.
   Diaz-Lopez, Andres
   Lapetra, Jose
   Munoz-Bravo, Carlos
   Aros, Fernando
   Fiol, Miquel
   Serra-Majem, Lluis
   Pinto, Xavier
   Castaner, Olga
   Fernandez-Lazaro, Cesar I.
   Portoles, Olga
   Babio, Nancy
   Estruch, Ramon
   Hernaez, Alvaro
TI Mediterranean Diet and Physical Activity Decrease the Initiation of
   Cardiovascular Drug Use in High Cardiovascular Risk Individuals: A
   Cohort Study
SO ANTIOXIDANTS
LA English
DT Article
DE mediterranean diet; physical activity; glucose-lowering drugs;
   antihypertensive drugs; statins; fibrates; antiplatelet drugs; vitamin K
   epoxide reductase inhibitors; antianginal drugs; cardiac glycosides
ID OXIDATIVE STRESS; ACTIVITY QUESTIONNAIRE; METABOLIC SYNDROME;
   HEART-FAILURE; ASSOCIATIONS; METAANALYSIS; VALIDATION; BIOMARKERS;
   ADHERENCE; ADULTS
AB Our aim was to assess whether long-term adherence to a Mediterranean diet (MedDiet) and leisure-time physical activity (LTPA) were associated with a lower initiation of cardiovascular drug use. We studied the association between cumulative average of MedDiet adherence and LTPA and the risk of cardiovascular drug initiation in older adults at high cardiovascular risk (PREvencion con DIeta MEDiterranea trial participants) non-medicated at baseline: glucose-lowering drugs (n = 4437), antihypertensives (n = 2145), statins (n = 3977), fibrates (n = 6391), antiplatelets (n = 5760), vitamin K antagonists (n = 6877), antianginal drugs (n = 6837), and cardiac glycosides (n = 6954). One-point increases in MedDiet adherence were linearly associated with a decreased initiation of glucose-lowering (HR: 0.76 [0.71-0.80]), antihypertensive (HR: 0.79 [0.75-0.82]), statin (HR: 0.82 [0.78-0.85]), fibrate (HR: 0.78 [0.68-0.89]), antiplatelet (HR: 0.79 [0.75-0.83]), vitamin K antagonist (HR: 0.83 [0.74; 0.93]), antianginal (HR: 0.84 [0.74-0.96]), and cardiac glycoside therapy (HR: 0.69 [0.56-0.84]). LTPA was non-linearly related to a delayed initiation of glucose-lowering, antihypertensive, statin, fibrate, antiplatelet, antianginal, and cardiac glycoside therapy (minimum risk: 180-360 metabolic equivalents of task-min/day). Both combined were synergistically associated with a decreased onset of glucose-lowering drugs (p-interaction = 0.04), antihypertensive drugs (p-interaction < 0.001), vitamin K antagonists (p-interaction = 0.04), and cardiac glycosides (p-interaction = 0.01). Summarizing, sustained adherence to a MedDiet and LTPA were associated with lower risk of initiating cardiovascular-related medications.
C1 [Ribo-Coll, Margarita; Castro-Barquero, Sara; Sacanella, Emilio; Ros, Emilio; Estruch, Ramon; Hernaez, Alvaro] August Pi & Sunyer Biomed Res Inst IDIBAPS, Barcelona 08036, Spain.
   [Ribo-Coll, Margarita] Univ Barcelona, Fac Pharm & Food Sci, PhD Program Food Sci & Nutr, Barcelona 08028, Spain.
   [Castro-Barquero, Sara; Sacanella, Emilio; Estruch, Ramon] Univ Barcelona, Fac Med & Hlth Sci, Dept Med, Barcelona 08036, Spain.
   [Castro-Barquero, Sara; Lassale, Camille; Sacanella, Emilio; Ros, Emilio; Toledo, Estefania; Sorli, Jose V.; Diaz-Lopez, Andres; Lapetra, Jose; Aros, Fernando; Fiol, Miquel; Serra-Majem, Lluis; Pinto, Xavier; Castaner, Olga; Fernandez-Lazaro, Cesar I.; Portoles, Olga; Babio, Nancy; Estruch, Ramon; Hernaez, Alvaro] Inst Salud Carlos III, Consorcio CIBER, MP Fisiopatol Obesidad Nutr CIBEROBN, Madrid 28029, Spain.
   [Lassale, Camille; Castaner, Olga] Hosp Mar Med Res Inst IMIM, Cardiovasc Risk & Nutr Res Grp, Barcelona 08003, Spain.
   [Sacanella, Emilio; Estruch, Ramon] Hosp Clin Barcelona, Internal Med Serv, Barcelona 08036, Spain.
   [Ros, Emilio] Hosp Clin Barcelona, Lipid Clin, Endocrinol & Nutr Serv, Barcelona 08036, Spain.
   [Toledo, Estefania] Univ Navarra, Dept Prevent Med & Publ Hlth, Pamplona 31008, Spain.
   [Toledo, Estefania; Fernandez-Lazaro, Cesar I.] Navarra Inst Hlth Res IdiSNA, Pamplona 31008, Spain.
   [Sorli, Jose V.; Castaner, Olga] Univ Valencia, Dept Prevent Med & Publ Hlth, Valencia 46010, Spain.
   [Diaz-Lopez, Andres] Univ Rovira & Virgili, Dept Ciencies Med Basiques, Unitat Nutr & Salut Publ, Reus 43201, Spain.
   [Diaz-Lopez, Andres] Inst Invest Sanitaria Pere Virgili IISPV, Reus 43204, Spain.
   [Lapetra, Jose] Distrito Sanitario Atenc Primaria Sevilla, Res Unit, Dept Family Med, Seville 41013, Spain.
   [Munoz-Bravo, Carlos] Univ Malaga, Dept Publ Hlth & Psychiat, Malaga 29071, Spain.
   [Aros, Fernando] Hosp Univ Alava, Dept Cardiol, Vitoria 01009, Spain.
   [Fiol, Miquel] Hosp Son Espases, Hlth Res Inst Balearic Isl IdISBa, Palma De Mallorca 07120, Spain.
   [Serra-Majem, Lluis] Univ Las Palmas Gran Canaria, Inst Invest Biomed & Sanitarias, Las Palmas Gran Canaria 35016, Spain.
   [Serra-Majem, Lluis] Ctr Hosp Univ Insular Materno Infantil, Serv Canario Salud, Las Palmas Gran Canaria 35016, Spain.
   [Pinto, Xavier] Hosp Univ Bellvitge, Lipids & Vasc Risk Unit, Internal Med, Lhospitalet De Llobregat 08907, Spain.
   [Estruch, Ramon] Univ Rovira & Virgili, Dept Bioquim & Biotecnol, Unitat Nutr Humana, Reus 43201, Spain.
   [Hernaez, Alvaro] Univ Ramon Llull, Blanquerna Sch Hlth Sci, Barcelona 08025, Spain.
   [Hernaez, Alvaro] Norwegian Inst Publ Hlth, Ctr Fertil & Hlth, N-0473 Oslo, Norway.
C3 University of Barcelona; Hospital Clinic de Barcelona; IDIBAPS;
   University of Barcelona; University of Barcelona; Instituto de Salud
   Carlos III; Hospital del Mar Research Institute; Hospital del Mar;
   University of Barcelona; Hospital Clinic de Barcelona; University of
   Barcelona; Hospital Clinic de Barcelona; University of Navarra;
   University of Navarra; University of Valencia; Universitat Rovira i
   Virgili; Universitat Rovira i Virgili; Institut d'Investigacio Sanitaria
   Pere Virgili (IISPV); Universidad de Malaga; University Hospital of
   Araba; Hospital Universitari Son Espases; Institut Investigacio
   Sanitaria Illes Balears (IdISBa); Universidad de Las Palmas de Gran
   Canaria; Institut d'Investigacio Biomedica de Bellvitge (IDIBELL);
   Bellvitge University Hospital; Universitat Rovira i Virgili; Universitat
   Ramon Llull; Norwegian Institute of Public Health (NIPH)
RP Hernáez, A (corresponding author), August Pi & Sunyer Biomed Res Inst IDIBAPS, Barcelona 08036, Spain.; Hernáez, A (corresponding author), Inst Salud Carlos III, Consorcio CIBER, MP Fisiopatol Obesidad Nutr CIBEROBN, Madrid 28029, Spain.; Hernáez, A (corresponding author), Univ Ramon Llull, Blanquerna Sch Hlth Sci, Barcelona 08025, Spain.; Hernáez, A (corresponding author), Norwegian Inst Publ Hlth, Ctr Fertil & Hlth, N-0473 Oslo, Norway.
EM mribocoll@gmail.com; sacastro@clinic.cat; classale@imim.es;
   esacane@clinic.cat; eros@clinic.cat; etoledo@unav.es; jose.sorli@uv.es;
   andres.diaz@urv.cat; joselapetra543@gmail.com; carlosmb@uma.es;
   aborau@secardiologia.es; miguel.fiol@ssib.es; lserra@dcc.ulpgc.es;
   xpinto@bellvitgehospital.cat; ocastaner@imim.es; cflazaro@unav.es;
   olga.portoles@uv.es; nancy.babio@urv.cat; restruch@clinic.cat;
   alvaro.hernaez@fhi.no
RI Lapetra, Jose/F-2552-2015; Babio, Nancy/AAN-2715-2020; Castaner,
   Olga/F-1533-2013; Sorlí, José/L-8758-2014; Hernaez,
   Alvaro/GXF-3337-2022; Estruch, Ramon/AAZ-3723-2020; Pintó,
   Xavier/AGI-4297-2022; Fernandez-Lazaro, Cesar/V-6390-2019; Lassale,
   Camille/ABE-7813-2020; Reparaz, Olga/AAB-3243-2019; , MIQUEL FIOL
   SALA/F-6793-2016; Toledo, Estefania/H-6211-2014
OI BABIO SANCHEZ, NANCY/0000-0003-3527-5277; Fernandez-Lazaro, Cesar
   I./0000-0003-2366-2528; Castaner Nino, Olga/0000-0003-3169-997X;
   Lassale, Camille/0000-0002-9340-2708; Estruch,
   Ramon/0000-0003-1260-4445; , MIQUEL FIOL SALA/0000-0002-5370-1391;
   Castro Barquero, Sara/0000-0002-6876-5443; Diaz-Lopez,
   Andres/0000-0002-7500-5629; Pinto Sala, Xavier/0000-0002-2216-2444; Ros,
   Emilio/0000-0002-2573-1294; Hernaez, Alvaro/0000-0001-8593-1477; Sorli,
   Jose V/0000-0002-0130-2006; Toledo, Estefania/0000-0002-6263-4434
FU Official College of Pharmacists of Barcelona (Col.legi Oficial de
   Farmaceutics de Barcelona, COFB), Instituto de Salud Carlos III
   [OBN17PI02, CB06/03/0019, CB06/03/0028, CD17/00122]; Agencia de Gestio
   d'Ajuts Universitaris i de Recerca [2017 BP 00021, 2017 SGR 222];
   Spanish Ministry of Science, Innovation, and Universities [FPU17/00785];
   European Regional Development Fund (ERDF)
FX This work was supported by grants of the Official College of Pharmacists
   of Barcelona (Col.legi Oficial de Farmaceutics de Barcelona, COFB),
   Instituto de Salud Carlos III [OBN17PI02, CB06/03/0019, CB06/03/0028,
   CD17/00122 to A.H.], Agencia de Gestio d'Ajuts Universitaris i de
   Recerca [2017 BP 00021 to C.L., 2017 SGR 222], the Spanish Ministry of
   Science, Innovation, and Universities [FPU17/00785 to S.C.-B.], and the
   European Regional Development Fund (ERDF). The funders had no role in
   study design, data collection and analysis, decision to publish, or
   preparation of the manuscript.
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NR 43
TC 1
Z9 1
U1 0
U2 8
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD MAR
PY 2021
VL 10
IS 3
AR 397
DI 10.3390/antiox10030397
PG 14
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA RD2ND
UT WOS:000633320700001
PM 33808041
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Palladini, G
   Ferrigno, A
   Di Pasqua, LG
   Berardo, C
   Rizzo, V
   Perlini, S
   Vairetti, M
AF Palladini, Giuseppina
   Ferrigno, Andrea
   Di Pasqua, Laura Giuseppina
   Berardo, Clarissa
   Rizzo, Vittoria
   Perlini, Stefano
   Vairetti, Mariapia
TI Associations between serum trace elements and inflammation in two animal
   models of nonalcoholic fatty liver disease
SO PLOS ONE
LA English
DT Article
ID URIC-ACID; METABOLIC SYNDROME; OXIDATIVE STRESS; TISSUE METAL; ZUCKER
   OBESE; CALCIUM; IRON; CHROMIUM; CHOLINE; COPPER
AB Background
   The comparison of hepatic steatosis animal models has allowed the understanding of mechanisms involved in the pathogenesis of non-alcoholic fatty liver disease (NAFLD) and the progression to nonalcoholic steatohepatitis (NASH). We investigated the changes in serum levels of trace elements and inflammation markers in fatty livers using two rat models of NAFLD, the methionine and choline deficient (MCD) diet model and Obese-Zucker rats.
   Material and methods
   NAFLD was induced in male Wistar rats by 3-week MCD diet administration, after which, blood samples were collected. 12-week old Obese (fa/fa) and Lean (fa/-) male Zucker rats were also used. Serum levels of hepatic enzymes, Urea, Uric acid, Ca-2+,Ca- Cl, Fe, K, Na, Mg and Zn were quantified, as well as the inflammation markers TNF-alpha, IL-1beta and IL-6.
   Results
   In MCD rats, a serum increase in Cl, Mg and Na and a decrease in Ca-2+,Ca- Zn were detected in comparison with control rats. An increase in only serum Ca2+ was found in Obese-Zucker rats. In MCD rat serum, Zn was inversely correlated with IL-1beta, IL-6, TNF-alpha, Urea and Uric Acid; Ca2+ was inversely correlated with IL-1beta, IL-6 and Urea; Cl and Mg were directly correlated with Uric Acid and Urea, respectively. In Obese-Zucker rats, Cl and IL-1beta were inversely correlated, whereas Ca2+ and Urea where directly correlated, as well Fe and TNF-alpha.
   Conclusions
   The serum concentrations of trace elements change significantly only in MCD rats, which spontaneously progress to NASH. The causes of these changes may be a result of defense strategies of the organism, which is regulated by immunoregulatory cytokines. These results might suggest that the impairment of trace element status should be taken into account when the effectiveness of a pharmacological treatment is under evaluation.
C1 [Palladini, Giuseppina; Ferrigno, Andrea; Di Pasqua, Laura Giuseppina; Berardo, Clarissa; Perlini, Stefano; Vairetti, Mariapia] Univ Pavia, Dept Internal Med & Therapeut, Pavia, Italy.
   [Palladini, Giuseppina] Fdn IRCCS Policlin San Matteo, Pavia, Italy.
   [Rizzo, Vittoria] Univ Pavia, Dept Mol Med, Pavia, Italy.
   [Perlini, Stefano] Fdn IRCCS Policlin San Matteo, Emergency Dept, Pavia, Italy.
C3 University of Pavia; IRCCS Fondazione San Matteo; University of Pavia;
   IRCCS Fondazione San Matteo
RP Ferrigno, A (corresponding author), Univ Pavia, Dept Internal Med & Therapeut, Pavia, Italy.
EM andrea.ferrigno@unipv.it
RI Ferrigno, Andrea/J-2087-2019; Di Pasqua, Laura/Y-3987-2019; Vairetti,
   Mariapia/AAM-1757-2020; Berardo, Clarissa/U-7316-2019; Perlini,
   Stefano/E-2670-2012; Palladini, Giuseppina/AAB-8694-2019
OI Palladini, Giuseppina/0000-0003-1312-7513; Ferrigno,
   Andrea/0000-0003-2337-2897; Di Pasqua, Laura
   Giuseppina/0000-0003-0103-1493; Vairetti, Mariapia/0000-0002-2464-6127
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NR 49
TC 4
Z9 4
U1 0
U2 8
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD DEC 11
PY 2020
VL 15
IS 12
AR e0243179
DI 10.1371/journal.pone.0243179
PG 13
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA PH0WM
UT WOS:000600144200048
PM 33306695
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Pongkan, W
   Jinawong, K
   Pratchayasakul, W
   Jaiwongkam, T
   Kerdphoo, S
   Tokuda, M
   Chattipakorn, SC
   Chattipakorn, N
AF Pongkan, Wanpitak
   Jinawong, Kewarin
   Pratchayasakul, Wasana
   Jaiwongkam, Thidarat
   Kerdphoo, Sasiwan
   Tokuda, Masaaki
   Chattipakorn, Siriporn C.
   Chattipakorn, Nipon
TI d-allulose provides cardioprotective effect by attenuating cardiac
   mitochondrial dysfunction in obesity-induced insulin-resistant rats
SO EUROPEAN JOURNAL OF NUTRITION
LA English
DT Article
DE d-allulose; Metformin; Cardiovascular health; Rat model; Diet-induced
   insulin resistance
ID DIETARY D-PSICOSE; HIGH-FAT DIET; OXIDATIVE STRESS; METABOLIC SYNDROME;
   LIPID-METABOLISM; D-FRUCTOSE; SUPPLEMENTATION; SUPPRESSES; MECHANISMS;
   INHIBITOR
AB Purpose Obesity-induced insulin resistant is associated with cardiovascular diseases via impairing cardiac mitochondria. Recently,d-allulose could protect beta-islets and improve insulin resistance. However, the effects ofd-allulose on the heart and cardiac mitochondrial function under obesity-induced insulin-resistant condition has not been investigated. In this study, we aimed to investigate the effects ofd-allulose on metabolic parameters, cardiac function, heart rate variability (HRV), cardiac mitochondrial function, and apoptosis in the heart of obesity-induced insulin-resistant rats induced by chronic high fat diet consumption. Methods Male Wistar rats (n = 24) received a normal fat diet (ND) or high fat diet (HFD) for 12 weeks. Then, HFD group was randomly divided into three subgroups to receive (1) HFD with distilled water, (2) HFD with 3% D-allulose 1.9 g/ kg center dot BW/ day (HFR), and (3) HFD with metformin 300 mg/kg center dot BW/ day (HFM) by diluted in drinking water daily for 12 weeks. At week 24, proposed study parameters were investigated. Results Chronic HFD consumption induced obesity-induced insulin resistant in rats and high fat diet impaired cardiac function and HRV. HFR rats had improved insulin sensitivity as indicated by decreasing HOMA index, plasma insulin, whereas HFM decreased body weight, visceral fat, plasma cholesterol, and plasma LDL. HFR and HFM provided similar efficacy in improving HRV and attenuating cardiac mitochondrial dysfunction, leading to improved cardiac function. Conclusions Even though this is the first investigation of thed-allulose impact on the heart with a relatively small sample size, it clearly demonstrated a beneficial effect on the heart.d-allulose exerted a therapeutic effect on metabolic parameters except for body weight and lipid profiles and provided cardioprotective effects similar to metformin via attenuating cardiac mitochondrial function in obesity-induced insulin-resistant rats.
C1 [Pongkan, Wanpitak; Jinawong, Kewarin; Pratchayasakul, Wasana; Jaiwongkam, Thidarat; Kerdphoo, Sasiwan; Chattipakorn, Siriporn C.; Chattipakorn, Nipon] Chiang Mai Univ, Fac Med, Cardiac Electrophysiol Res & Training Ctr, Chiang Mai 50200, Thailand.
   [Jinawong, Kewarin; Pratchayasakul, Wasana; Jaiwongkam, Thidarat; Kerdphoo, Sasiwan; Chattipakorn, Siriporn C.; Chattipakorn, Nipon] Chiang Mai Univ, Fac Med, Dept Physiol, Cardiac Electrophysiol Unit, Chiang Mai 50200, Thailand.
   [Jinawong, Kewarin; Pratchayasakul, Wasana; Jaiwongkam, Thidarat; Kerdphoo, Sasiwan; Chattipakorn, Siriporn C.; Chattipakorn, Nipon] Chiang Mai Univ, Ctr Excellence Cardiac Electrophysiol Res, Chiang Mai, Thailand.
   [Pongkan, Wanpitak] Chiang Mai Univ, Fac Vet Med, Dept Vet Biosci & Publ Hlth, Chiang Mai 50100, Thailand.
   [Tokuda, Masaaki] Kagawa Univ, Int Inst Rare Sugar Res & Educ, Takamatsu, Kagawa 7608521, Japan.
C3 Chiang Mai University; Chiang Mai University; Chiang Mai University;
   Chiang Mai University; Kagawa University
RP Chattipakorn, N (corresponding author), Chiang Mai Univ, Fac Med, Cardiac Electrophysiol Res & Training Ctr, Chiang Mai 50200, Thailand.; Chattipakorn, N (corresponding author), Chiang Mai Univ, Fac Med, Dept Physiol, Cardiac Electrophysiol Unit, Chiang Mai 50200, Thailand.; Chattipakorn, N (corresponding author), Chiang Mai Univ, Ctr Excellence Cardiac Electrophysiol Res, Chiang Mai, Thailand.
EM nchattip@gmail.com
RI Chattipakorn, Nipon/AAJ-4049-2021; Pongkan, Wanpitak/N-8420-2018
OI Chattipakorn, Nipon/0000-0003-3026-718X; Chattipakorn,
   Siriporn/0000-0003-1677-7052; Pongkan, Wanpitak/0000-0001-6788-7740
FU Research and Development Department; Matsutani Chemical Industry
   Company; Chiang Mai University Center of Excellence Award; National
   Science and Technology Development Agency Thailand; National Research
   Council of Thailand
FX This work was supported by grants from the Research and Development
   Department, Matsutani Chemical Industry Company, and the Chiang Mai
   University Center of Excellence Award. NC is also supported by the
   Research Chair grant from the National Science and Technology
   Development Agency Thailand, and SCC is supported by the Senior Research
   Scholar grant from the National Research Council of Thailand. All
   funders were not involved in the data collection, interpretation, and
   report in this manuscript. The authors would like to thank Ms. Busarin
   Arunsak, Ms. Kodchanan Singhanat, and Mr. Chayodom Maneechote for their
   technical assistance.
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NR 50
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U2 24
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1436-6207
EI 1436-6215
J9 EUR J NUTR
JI Eur. J. Nutr.
PD JUN
PY 2021
VL 60
IS 4
BP 2047
EP 2061
DI 10.1007/s00394-020-02394-y
EA OCT 2020
PG 15
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA SF0TU
UT WOS:000574805800001
PM 33011844
DA 2025-06-11
ER

PT J
AU Ma, ZM
   Zhang, JB
   Kang, XP
   Xu, CN
   Sun, C
   Tao, LX
   Zheng, DQ
   Han, YM
   Li, Q
   Guo, XH
   Yang, XH
AF Ma, Zhimin
   Zhang, Jingbo
   Kang, Xiaoping
   Xu, Chaonan
   Sun, Ce
   Tao, Lixin
   Zheng, Deqiang
   Han, Yumei
   Li, Qiang
   Guo, Xiuhua
   Yang, Xinghua
TI Hyperuricemia precedes non-alcoholic fatty liver disease with abdominal
   obesity moderating this unidirectional relationship: Three longitudinal
   analyses
SO ATHEROSCLEROSIS
LA English
DT Article
DE Hyperuricemia; Non-alcoholic fatty liver disease; Serum uric acid;
   Hepatic steatosis; Bidirectional analysis; Temporal relationship;
   Cross-lagged panel analysis
ID SERUM URIC-ACID; INSULIN-RESISTANCE; METABOLIC SYNDROME; OXIDATIVE
   STRESS; PREVALENCE; RISK; ATHEROSCLEROSIS; METAANALYSIS; ASSOCIATION;
   ACTIVATION
AB Background and aims: The temporal relationship between hyperuricemia and non-alcoholic fatty liver disease (NAFLD) is debatable. This study aimed to explore whether there exists a bidirectional or temporal relationship between them.
   Methods: A total of 11,585 participants were recruited from the Beijing Health Management Cohort during the period 2012-2016. We evaluated whether hyperuricemia was associated with NAFLD development (part I) and whether NAFLD was associated with hyperuricemia incidence (part II) using a logistic regression model. Further, the cross-lagged panel analysis model was used to simultaneously examine the bidirectional relationship between hepatic steatosis and serum uric acid (SUA) (part III). Subgroup and interaction analyses were also performed to assess whether other variables moderated those relationships.
   Results: In part I, multiple logistic regression indicated that baseline hyperuricemia was associated with the development of NAFLD (OR = 1.5970, p < 0.0001). In part II, multiple logistic regression showed that baseline NAFLD was not correlated with hyperuricemia incidence (OR = 0.8600, p = 0.1976). In part III, cross-lagged panel analyses indicated that the standard regression coefficient of baseline SUA to follow-up hepatic steatosis (0.1516) was significantly greater than the coefficient from the baseline hepatic steatosis to follow-up SUA (-0.0044) with p < 0.0001 for the difference. This indicated a unidirectional relationship from baseline SUA to follow-up hepatic steatosis, suggesting hyperuricemia may precede NAFLD; and this relationship was not affected by age, sex, dyslipidemia, metabolism syndrome, diabetes but was moderated by abdominal obesity.
   Conclusions: This study demonstrated a unidirectional relationship from hyperuricemia to NAFLD incidence, and suggested that lowering SUA levels in hyperuricemia patients may prevent subsequent NAFLD.
C1 [Ma, Zhimin; Tao, Lixin; Zheng, Deqiang; Guo, Xiuhua; Yang, Xinghua] Capital Med Univ, Sch Publ Hlth, 10 Xitoutiao, Beijing 100069, Peoples R China.
   [Ma, Zhimin; Tao, Lixin; Zheng, Deqiang; Guo, Xiuhua; Yang, Xinghua] Beijing Municipal Key Lab Clin Epidemiol, Beijing, Peoples R China.
   [Zhang, Jingbo; Han, Yumei; Li, Qiang] Beijing Phys Examinat Ctr, Dept Informat, Beijing, Peoples R China.
   [Kang, Xiaoping] Beijing Xiaotangshan Hosp, Rehabil Ctr, Beijing, Peoples R China.
   [Xu, Chaonan] Peking Univ Third Hosp, Med Engn Dept, Beijing, Peoples R China.
   [Sun, Ce] China Med Univ, Shengjing Hosp, Dept Clin Epidemiol, Shenyang, Peoples R China.
C3 Capital Medical University; China Medical University
RP Yang, XH (corresponding author), Capital Med Univ, Sch Publ Hlth, 10 Xitoutiao, Beijing 100069, Peoples R China.
EM xinghuayang@ccmu.edu.cn
RI TAO, Li/HIR-4254-2022; zhang, jingbo/JTU-4627-2023
OI Ma, Zhimin/0000-0002-1354-1055
FU Beijing Natural Science Foundation [7202010]; Beijing Physical
   Examination Center [BJTJ-2018-05]
FX This study was supported by the Beijing Natural Science Foundation
   (7202010), and Beijing Physical Examination Center (BJTJ-2018-05).
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NR 57
TC 18
Z9 21
U1 2
U2 17
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0021-9150
EI 1879-1484
J9 ATHEROSCLEROSIS
JI Atherosclerosis
PD OCT
PY 2020
VL 311
BP 44
EP 51
DI 10.1016/j.atherosclerosis.2020.08.006
PG 8
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA OC7WB
UT WOS:000579367200006
PM 32937242
DA 2025-06-11
ER

PT J
AU Khorasanchi, Z
   Bahrami, A
   Tavallaee, S
   Khorasani, ZM
   Afkhamizadeh, M
   Khodashenas, E
   Ferns, GA
   Ghayour-Mobarhan, M
AF Khorasanchi, Zahra
   Bahrami, Afsane
   Tavallaee, Shima
   Khorasani, Zahra Mazloum
   Afkhamizadeh, Mozhgan
   Khodashenas, Ezzat
   Ferns, Gordon A.
   Ghayour-Mobarhan, Majid
TI Effect of high-dose vitamin D supplementation on antibody titers to heat
   shock protein 27 in adolescent girls
SO JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
LA English
DT Article
DE heat shock protein; inflammation; RDW; vitamin D supplementation
ID CELL DISTRIBUTION WIDTH; C-REACTIVE PROTEIN; OXIDANT-ANTIOXIDANT
   BALANCE; NF-KAPPA-B; METABOLIC SYNDROME; 1,25-DIHYDROXYVITAMIN D-3; D
   DEFICIENCY; INFLAMMATION; RISK; DISEASE
AB Background: Although vitamin D deficiency is associated with several inflammatory conditions, there have been few studies on the effects of vitamin D supplementation on markers of oxidative stress (OS) and inflammation. The aim of the current study was to evaluate the effects of high-dose vitamin D supplementation on heat shock protein 27 antibody (anti-Hsp27) titers in adolescent girls.
   Methods: Five hundred and fifty adolescent girls received vitamin D3 at a dose of 50,000 IU/week for 9 weeks. Demographic, clinical and biochemical markers including serum fasting blood glucose (FBG), lipid profile and anti-Hsp27 titers as well as hematological parameters including white blood cell (WBC) count and red blood cell (RBC) distribution width (RDW) were determined in all the subjects at baseline and at the end of the study.
   Results: Serum vitamin D significantly increased from 6.4 (4.2 9.6) ng/mL to 35.6 (25.8 47.5) ng/mL (p <0.001) following the intervention. Furthermore, serum anti-Hsp27 titers were significantly lower after the 9-week vitamin D administration period (0.22 [0.12-0.33] optical density [OD] vs. 0.19 [0.11-0.31] OD; p = 0.002). A significant correlation was found between serum anti-Hsp27 and RDW (r = 0.13, p = 0.037). The reduction in RDW values after intervention was particularly evident in subjects with the greatest increase in serum vitamin D levels.
   Conclusions: High-dose vitamin D supplementation was found to reduce antibody titers to Hsp27. Further randomized placebo-controlled trials are warranted to determine the long-term effect of vitamin D administration on the inflammatory process especially that associated with chronic disease.
C1 [Ghayour-Mobarhan, Majid] Mashhad Univ Med Sci, Fac Med, Metab Syndrome Res Ctr, Mashhad, Razavi Khorasan, Iran.
   [Khorasanchi, Zahra] Mashhad Univ Med Sci, Fac Med, Dept Nutr, Mashhad, Razavi Khorasan, Iran.
   [Bahrami, Afsane] Birjand Univ Med Sci, Cellular & Mol Res Ctr, Birjand, Iran.
   [Tavallaee, Shima] Mashhad Univ Med Sci, Metab Syndrome Res Ctr, Mashhad, Razavi Khorasan, Iran.
   [Khorasani, Zahra Mazloum] Mashhad Univ Med Sci, Endocrine Res Ctr, Mashhad, Razavi Khorasan, Iran.
   [Afkhamizadeh, Mozhgan] Mashhad Univ Med Sci, Ghaem Hosp, Dept Endocrinol, Mashhad, Razavi Khorasan, Iran.
   [Khodashenas, Ezzat] Mashhad Univ Med Sci, Sch Med, Dept Pediat, Mashhad, Razavi Khorasan, Iran.
   [Ferns, Gordon A.] Brighton & Sussex Med Sch, Div Med Educ, Brighton, Sussex, England.
C3 Mashhad University of Medical Sciences; Mashhad University of Medical
   Sciences; Birjand University of Medical Sciences; Mashhad University of
   Medical Sciences; Mashhad University of Medical Sciences; Mashhad
   University of Medical Sciences; Mashhad University of Medical Sciences;
   University of Sussex; University of Brighton
RP Ghayour-Mobarhan, M (corresponding author), Mashhad Univ Med Sci, Fac Med, Metab Syndrome Res Ctr, Mashhad, Razavi Khorasan, Iran.
EM Ghayourm@mums.ac.ir
RI khorasani, zahra/J-9553-2018; Ghayour-Mobarhan, Majid/AAY-5963-2020;
   khorasanchi, zahra/ABD-4405-2021; bahrami, afsaneh/Q-3369-2018
OI khorasanchi, zahra/0000-0001-9579-9465; Bahrami,
   Afsane/0000-0002-4563-6112
FU Mashhad University of Medical Sciences [931188]
FX This study was supported by Mashhad University of Medical Sciences,
   http://dx.doi.org/10.13039/501100004748 (grant number 931188).
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   Zhou XC, 2015, AMINO ACIDS, V47, P2635, DOI 10.1007/s00726-015-2056-4
NR 69
TC 2
Z9 2
U1 0
U2 4
PU WALTER DE GRUYTER GMBH
PI BERLIN
PA GENTHINER STRASSE 13, D-10785 BERLIN, GERMANY
SN 0334-018X
EI 2191-0251
J9 J PEDIATR ENDOCR MET
JI J. Pediatr. Endocrinol. Metab.
PD MAY
PY 2020
VL 33
IS 5
BP 613
EP 621
DI 10.1515/jpem-2019-0288
PG 9
WC Endocrinology & Metabolism; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Pediatrics
GA LS1FH
UT WOS:000536137100006
PM 32352398
OA Green Accepted, Green Submitted
DA 2025-06-11
ER

PT J
AU Kunutsor, SK
   Frysz, M
   Verweij, N
   Kieneker, LM
   Bakker, SJL
   Dullaart, RPF
AF Kunutsor, Setor K.
   Frysz, Monika
   Verweij, Niek
   Kieneker, Lyanne M.
   Bakker, Stephan J. L.
   Dullaart, Robin P. F.
TI Circulating total bilirubin and risk of non-alcoholic fatty liver
   disease in the PREVEND study: observational findings and a Mendelian
   randomization study
SO EUROPEAN JOURNAL OF EPIDEMIOLOGY
LA English
DT Article
DE Total bilirubin; Non-alcoholic fatty liver disease; Cohort study;
   Mendelian randomization
ID CORONARY-HEART-DISEASE; SERUM BILIRUBIN; OXIDATIVE STRESS;
   UGT1A1-ASTERISK-28 ALLELE; CARDIOVASCULAR-DISEASE; REGRESSION DILUTION;
   METABOLIC SYNDROME; GILBERT-SYNDROME; ASSOCIATION; HYPERBILIRUBINEMIA
AB The relationship between circulating total bilirubin and incident non-alcoholic fatty liver disease (NAFLD) is uncertain. We aimed to assess the association of total bilirubin with the risk of new-onset NAFLD and investigate any causal relevance to the association using a Mendelian randomization (MR) study. Plasma total bilirubin levels were measured at baseline in the PREVEND prospective study of 3824 participants (aged 28-75 years) without pre-existing cardiovascular disease or NAFLD. Incident NAFLD was estimated using the biomarker-based algorithms, fatty liver index (FLI) and hepatic steatosis index (HSI). Odds ratios (ORs) (95% confidence intervals) for NAFLD were assessed. The genetic variant rs6742078 located in the UDP-glucuronosyltransferase (UGT1A1) locus was used as an instrumental variable. Participants were followed up for a mean duration of 4.2 years. The multivariable adjusted OR (95% CIs) for NAFLD as estimated by FLI (434 cases) was 0.82 (0.73-0.92; p=0.001) per 1 standard deviation (SD) change in log(e) total bilirubin. The corresponding adjusted OR (95% CIs) for NAFLD as estimated by HSI (452 cases) was 0.87 (0.78-0.97; p=0.012). The rs6742078 variant explained 20% of bilirubin variation. The ORs (95% CIs) for a 1 SD genetically elevated total bilirubin level was 0.98 (0.69-1.38; p=0.900) for FLI and 1.14 (0.81-1.59; p=0.451) for HSI. Elevated levels of total bilirubin were not causally associated with decreased risk of NAFLD based on MR analysis. The observational association may be driven by biases such as unmeasured confounding and/or reverse causation. However, due to low statistical power, larger-scale investigations are necessary to draw definitive conclusions.
C1 [Kunutsor, Setor K.] Univ Hosp Bristol NHS Fdn Trust, Bristol Biomed Res Ctr, Natl Inst Hlth Res, Bristol, Avon, England.
   [Kunutsor, Setor K.] Univ Bristol, Bristol, Avon, England.
   [Kunutsor, Setor K.; Frysz, Monika] Univ Bristol, Bristol Med Sch, Translat Hlth Sci, Musculoskeletal Res Unit,Southmead Hosp, Learning & Res Bldg,Level 1, Bristol BS10 5NB, Avon, England.
   [Verweij, Niek] Univ Groningen, Dept Cardiol, Groningen, Netherlands.
   [Verweij, Niek; Kieneker, Lyanne M.; Bakker, Stephan J. L.; Dullaart, Robin P. F.] Univ Med Ctr Groningen, Groningen, Netherlands.
   [Kieneker, Lyanne M.; Bakker, Stephan J. L.] Univ Groningen, Dept Nephrol Med, Groningen, Netherlands.
   [Dullaart, Robin P. F.] Univ Groningen, Dept Endocrinol, Groningen, Netherlands.
C3 University of Bristol; University of Bristol; Southmead Hospital;
   University of Bristol; University of Groningen; University of Groningen;
   University of Groningen; University of Groningen
RP Kunutsor, SK (corresponding author), Univ Hosp Bristol NHS Fdn Trust, Bristol Biomed Res Ctr, Natl Inst Hlth Res, Bristol, Avon, England.; Kunutsor, SK (corresponding author), Univ Bristol, Bristol, Avon, England.; Kunutsor, SK (corresponding author), Univ Bristol, Bristol Med Sch, Translat Hlth Sci, Musculoskeletal Res Unit,Southmead Hosp, Learning & Res Bldg,Level 1, Bristol BS10 5NB, Avon, England.
EM skk31@cantab.net
RI Frysz, Monika/AAD-9801-2022; Verweij, Niek/ABC-6249-2021; Kunutsor,
   Setor/H-9807-2019; Bakker, Stephan/J-4023-2015
OI Bakker, Stephan/0000-0003-3356-6791; KUNUTSOR,
   SETOR/0000-0002-2625-0273; Verweij, Niek/0000-0002-4303-7685
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NR 51
TC 31
Z9 34
U1 0
U2 10
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0393-2990
EI 1573-7284
J9 EUR J EPIDEMIOL
JI Eur. J. Epidemiol.
PD FEB
PY 2020
VL 35
IS 2
BP 123
EP 137
DI 10.1007/s10654-019-00589-0
PG 15
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA LN9DE
UT WOS:000533231000004
PM 31773475
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Moore, ES
   Daugherity, EK
   Karambizi, DI
   Cummings, BP
   Behling-Kelly, E
   Schaefer, DMW
   Southard, TL
   McFadden, JW
   Weiss, RS
AF Moore, Elizabeth S.
   Daugherity, Erin K.
   Karambizi, David, I
   Cummings, Bethany P.
   Behling-Kelly, Erica
   Schaefer, Deanna M. W.
   Southard, Teresa L.
   McFadden, Joseph W.
   Weiss, Robert S.
TI Sex-specific hepatic lipid and bile acid metabolism alterations in
   Fancd2-deficient mice following dietary challenge
SO JOURNAL OF BIOLOGICAL CHEMISTRY
LA English
DT Article
DE cholesterol metabolism; metabolic syndrome; DNA damage response; fatty
   acid metabolism; lipid metabolism; liver metabolism; cholestasis;
   Fanconi anemia complementation group D2 (FANCD2); Fanconi anemia;
   nonalcoholic fatty liver disease
ID FANCONI-ANEMIA; INSULIN-RESISTANCE; MITOCHONDRIAL DYSFUNCTION;
   PHOSPHOLIPID-COMPOSITION; OXIDATIVE STRESS; CHOLESTEROL; LIVER; CELLS;
   PATHWAY; PROTEIN
AB Defects in the Fanconi anemia (FA) DNA damage?response pathway result in genomic instability, developmental defects, hematopoietic failure, cancer predisposition, and metabolic disorders. The endogenous sources of damage contributing to FA phenotypes and the links between FA and metabolic disease remain poorly understood. Here, using mice lacking the Fancd2 gene, encoding a central FA pathway component, we investigated whether the FA pathway protects against metabolic challenges. Fancd2(?/?) and wildtype (WT) mice were fed a standard diet (SD), a diet enriched in fat, cholesterol, and cholic acid (Paigen diet), or a diet enriched in lipid alone (high-fat diet (HFD)). Fancd2(?/?) mice developed hepatobiliary disease and exhibited decreased survival when fed a Paigen diet but not a HFD. Male Paigen diet?fed mice lacking Fancd2 had significant biliary hyperplasia, increased serum bile acid concentration, and increased hepatic pathology. In contrast, female mice were similarly impacted by Paigen diet feeding regardless of Fancd2 status. Upon Paigen diet challenge, male Fancd2(?/?) mice had altered expression of genes encoding hepatic bile acid transporters and cholesterol and fatty acid metabolism proteins, including Scp2/x, Abcg5/8, Abca1, Ldlr, Srebf1, and Scd-1. Untargeted lipidomic profiling in liver tissue revealed 132 lipid species, including sphingolipids, glycerophospholipids, and glycerolipids, that differed significantly in abundance depending on Fancd2 status in male mice. We conclude that the FA pathway has sex-specific impacts on hepatic lipid and bile acid metabolism, findings that expand the known functions of the FA pathway and may provide mechanistic insight into the metabolic disease predisposition in individuals with FA.
C1 [Moore, Elizabeth S.; Daugherity, Erin K.; Karambizi, David, I; Cummings, Bethany P.; Southard, Teresa L.; Weiss, Robert S.] Cornell Univ, Dept Biomed Sci, T2-006C Vet Res Tower, Ithaca, NY 14853 USA.
   [Behling-Kelly, Erica] Cornell Univ, Dept Populat Med & Diagnost Sci, Ithaca, NY 14853 USA.
   [McFadden, Joseph W.] Cornell Univ, Dept Anim Sci, Ithaca, NY 14853 USA.
   [Daugherity, Erin K.] Cornell Univ, Ctr Anim Resources & Educ, Ithaca, NY 14853 USA.
   [Schaefer, Deanna M. W.] Univ Tennessee, Dept Biomed & Diagnost Sci, Knoxville, TN 37996 USA.
C3 Cornell University; Cornell University; Cornell University; Cornell
   University; University of Tennessee System; University of Tennessee
   Knoxville; UT Institute of Agriculture
RP Weiss, RS (corresponding author), Cornell Univ, Dept Biomed Sci, T2-006C Vet Res Tower, Ithaca, NY 14853 USA.
EM rsw26@cornell.edu
OI Schaefer, Deanna M. W./0000-0002-5260-2180; Weiss,
   Robert/0000-0003-3327-1379; Moore, Elizabeth/0000-0003-2502-6429
FU Cornell University College of Veterinary Medicine; National Institutes
   of Health Training [T32 ODO011000]
FX This work was supported in part by a Cornell University College of
   Veterinary Medicine resident research grant and National Institutes of
   Health Training Grant Award T32 ODO011000 (to E. S. M.). The authors
   declare that they have no conflicts of interest with the contents of
   this article. The content is solely the responsibility of the authors
   and does not necessarily represent the official views of the National
   Institutes of Health.
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NR 74
TC 6
Z9 7
U1 0
U2 7
PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
PI ROCKVILLE
PA 11200 ROCKVILLE PIKE, SUITE 302, ROCKVILLE, MD, UNITED STATES
SN 0021-9258
EI 1083-351X
J9 J BIOL CHEM
JI J. Biol. Chem.
PD OCT 25
PY 2019
VL 294
IS 43
BP 15623
EP 15637
DI 10.1074/jbc.RA118.005729
PG 15
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA JQ9JD
UT WOS:000499253000007
PM 31434739
OA Green Published
DA 2025-06-11
ER

PT J
AU McCarty, MF
   Iloki-Assanga, S
   Lujan, LML
   DiNicolantonio, JJ
AF McCarty, Mark F.
   Iloki-Assanga, Simon
   Lujan, Lidianys Maria Lewis
   DiNicolantonio, James J.
TI Activated glycine receptors may decrease endosomal NADPH oxidase
   activity by opposing ClC-3-mediated efflux of chloride from endosomes
SO MEDICAL HYPOTHESES
LA English
DT Article
ID N-TERMINAL KINASE; INCREASED OXIDATIVE STRESS; TYROSINE-PHOSPHATASE 1B;
   FACTOR-KAPPA-B; INSULIN-RESISTANCE; HEME OXYGENASE-1; TNF-ALPHA; DIETARY
   GLYCINE; ADIPOSE-TISSUE; ADIPONECTIN EXPRESSION
AB Receptor-mediated activation of NADPH oxidase complexes commonly occurs in endosomes; the hydrogen peroxide produced by the dismutation of superoxide generated within the endosomes often functions to boost receptor function by reversibly inhibiting protein tyrosine phosphatases or by promoting formation of signaling complexes. NADPH oxidase-mediated formation of superoxide entails transfer of two electrons (provided by NADPH) from the cytosol to the endosomal lumen, where two molecules of superoxide are generated. This charge transfer must be balanced if NADPH oxidase activity is to be sustained. In many cells, this balance is achieved by ClC-3, a chloride-proton antiporter which can extrude two chlorides from the endosome to balance the importation of two electrons. The efficiency of this chloride extrusion will evidently be contingent on the cytosolic chloride level. Pro-inflammatory hormones which stimulate NADPH oxidase activity in endosomes have been shown to promote chloride extrusion from the cell, thereby expediting endosomal chloride export. Conversely, high cytosolic chloride could potentially slow endosomal NADPH oxidase activity by impeding ClC-3-mediated chloride export. Glycine-activated, strychnine-inhibitable chloride channels, which boost intracellular chloride in cells which maintain intracellular chloride levels lower than that of plasma, have shown anti-inflammatory and anti-angiogenic activity in cell culture and rodent studies. It is proposed that many of these effects may be attributable to glycine-mediated suppression of endosomal NADPH oxidase activity. This model suggests that supplemental glycine may have utility for prevention and control of atherosclerosis, heart failure, angiogenesis associated with cancer or retinal disorders, and a range of inflammation-driven syndromes including metabolic syndrome; and it might complement the suppression of NADPH oxidase activity achievable with phycocyanobilin-enriched spirulina extracts.
C1 [McCarty, Mark F.; Iloki-Assanga, Simon; Lujan, Lidianys Maria Lewis; DiNicolantonio, James J.] Catalyt Longev, 811 B Nahant Ct, San Diego, CA 92109 USA.
   [McCarty, Mark F.; Iloki-Assanga, Simon; Lujan, Lidianys Maria Lewis; DiNicolantonio, James J.] Univ Sonora, Dept Ciencias Quim Biol, Hermosillo, Sonora, Mexico.
   [McCarty, Mark F.; Iloki-Assanga, Simon; Lujan, Lidianys Maria Lewis; DiNicolantonio, James J.] St Lukes Mid Amer Heart Inst, Dept Prevent Cardiol, Kansas City, KS USA.
C3 Universidad de Sonora; Saint Luke's Mid America Heart Institute
RP McCarty, MF (corresponding author), Catalyt Longev, 811 B Nahant Ct, San Diego, CA 92109 USA.
EM markfmccarty@gmail.com
RI Lewis Luján, Lidianys María/ISA-4070-2023; Lewis Lujan, Lidianys
   Maria/ISV-3783-2023; ILOKI ASSANGA, SIMON BERNARD/GNP-3218-2022
OI Lewis Lujan, Lidianys Maria/0000-0002-6548-3723; ILOKI ASSANGA, SIMON
   BERNARD/0000-0002-2058-5881
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NR 95
TC 7
Z9 7
U1 0
U2 12
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0306-9877
EI 1532-2777
J9 MED HYPOTHESES
JI Med. Hypotheses
PD FEB
PY 2019
VL 123
BP 125
EP 129
DI 10.1016/j.mehy.2019.01.012
PG 5
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA HL3DZ
UT WOS:000458594400031
PM 30696582
DA 2025-06-11
ER

PT J
AU Doosti-Irani, A
   Ostadmohammadi, V
   Mirhosseini, N
   Mansournia, MA
   Reiter, RJ
   Kashanian, M
   Rahimi, M
   Razavi, M
   Asemi, Z
AF Doosti-Irani, Amin
   Ostadmohammadi, Vahidreza
   Mirhosseini, Naghmeh
   Mansournia, Mohammad Ali
   Reiter, Russel J.
   Kashanian, Maryam
   Rahimi, Maryam
   Razavi, Maryamalsadat
   Asemi, Zatollah
TI The Effects of Melatonin Supplementation on Glycemic Control: A
   Systematic Review and Meta-Analysis of Randomized Controlled Trials
SO HORMONE AND METABOLIC RESEARCH
LA English
DT Review
DE melatonin; glycemic control; insulin resistance; meta-analysis
ID CONTROLLED CLINICAL-TRIAL; OXIDATIVE STRESS; DOUBLE-BLIND; METABOLIC
   SYNDROME; GLUCOSE; INSULIN; RATS; SECRETION; COMPLICATIONS; PARAMETERS
AB This systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted to clarify the effect of melatonin supplementation on glycemic control. Databases including PubMed, MEDLINE, EMBASE, Web of Science, and Cochrane Central Register of Controlled Trials were searched until July 30th, 2018. Two reviewers independently assessed study eligibility, extracted data, and evaluated the risk of bias for included trials. Heterogeneity among included studies was assessed using Cochran's Q test and I-square (I2) statistic. Data were pooled using random-effect models and standardized mean difference (SMD) was considered as the overall effect size. Twelve trials out of 292 selected reports were identified eligible to be included in current meta-analysis. The pooled findings indicated that melatonin supplementation significantly reduced fasting glucose (SMD = -6.34; 95 % CI, -12.28, -0.40; p = 0.04; I2: 65.0) and increased the quantitative insulin sensitivity check index (QUICKI) (SMD = 0.01; 95 % CI, 0.00, 0.02; p = 0.01; I2: 0.0). However, melatonin administration did not significantly influence insulin levels (SMD = -1.03; 95 % CI, -3.82, 1.77; p = 0.47; I2: 0.53), homeostasis model assessment of insulin resistance (HOMA-IR) (SMD = -0.34; 95 % CI, -1.25, 0.58; p = 0.37; I2: 0.37) or HbA1c levels (SMD = -0.22; 95 % CI, -0.47, 0.03; p = 0.08; I2: 0.0). In summary, the current meta- analysis showed a promising effect of melatonin supplementation on glycemic control through reducing fasting glucose and increasing QUICKI, yet additional prospective studies are recommended, using higher supplementation doses and longer intervention period, to confirm the impact of melatonin on insulin levels, HOMA-IR and HbA1c.
C1 [Doosti-Irani, Amin] Hamadan Univ Med Sci, Sch Publ Hlth, Dept Epidemiol, Hamadan, Iran.
   [Doosti-Irani, Amin] Hamadan Univ Med Sci, Sch Publ Hlth, Modeling Noncommunicable Dis Res Ctr, Hamadan, Iran.
   [Ostadmohammadi, Vahidreza; Asemi, Zatollah] Kashan Univ Med Sci, Res Ctr Biochem & Nutr Metab Dis, Kashan, Iran.
   [Mirhosseini, Naghmeh] Univ Saskatchewan, Sch Publ Hlth, Saskatoon, SK, Canada.
   [Mansournia, Mohammad Ali] Univ Tehran Med Sci, Sch Publ Hlth, Dept Epidemiol & Biostat, Tehran, Iran.
   [Reiter, Russel J.] UT Hlth San Antonio, Dept Cellular & Struct Biol, San Antonio, TX USA.
   [Kashanian, Maryam; Rahimi, Maryam] Iran Univ Med Sci, Sch Med, Dept Gynecol & Obstet, Tehran, Iran.
   [Razavi, Maryamalsadat] Ardabil Univ Med Sci, Sch Med, Dept Gynecol & Obstet, Ardebil, Iran.
C3 Hamadan University of Medical Sciences; Hamadan University of Medical
   Sciences; University of Saskatchewan; Tehran University of Medical
   Sciences; University of Texas System; University of Texas Health Science
   Center at San Antonio; Iran University of Medical Sciences; Ardabil
   University of Medical Sciences
RP Asemi, Z (corresponding author), Kashan Univ Med Sci, Res Ctr Biochem & Nutr Metab Dis, Kashan, Iran.
EM asemi_r@yahoo.com
RI mansournia, Mohammad/AFA-8899-2022; Mirhosseini, Naghmeh/AAC-7730-2019;
   Reiter, Russel/D-3221-2009; Doosti-Irani, Amin/Q-1260-2016; asemi,
   zatollah/J-2677-2018; Ostadmohammadi, Vahidreza/A-6248-2018
OI Ostadmohammadi, Vahidreza/0000-0002-4633-5397
FU Kashan University of Medical Sciences (KAUMS)
FX The research grant provided by Research Deputy of Kashan University of
   Medical Sciences (KAUMS).
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NR 44
TC 37
Z9 37
U1 0
U2 4
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0018-5043
EI 1439-4286
J9 HORM METAB RES
JI Horm. Metab. Res.
PD NOV
PY 2018
VL 50
IS 11
BP 783
EP 790
DI 10.1055/a-0752-8462
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA GZ1UX
UT WOS:000449161200001
PM 30396207
OA Bronze
DA 2025-06-11
ER

PT J
AU Eshak, ES
   Iso, H
   Maruyama, K
   Muraki, I
   Tamakoshi, A
AF Eshak, Ehab S.
   Iso, Hiroyasu
   Maruyama, Koutatsu
   Muraki, Isao
   Tamakoshi, Akiko
TI Associations between dietary intakes of iron, copper and zinc with risk
   of type 2 diabetes mellitus: A large population-based prospective cohort
   study
SO CLINICAL NUTRITION
LA English
DT Article
DE Cohort study; Copper; Iron; Japanese; Type 2 diabetes mellitus; Zinc
ID PROSPECTIVE JIANGSU NUTRITION; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   SERUM FERRITIN; CARDIOVASCULAR-DISEASE; OXIDATIVE STRESS; GLYCEMIC
   CONTROL; JAPANESE ADULTS; CHINESE ADULTS; RED MEAT
AB Background & aims: Abnormal homeostasis of iron, copper and zinc has been included in the pathogenesis of type 2 diabetes mellitus (T2DM). However, the evidence of associations between dietary intakes of these elements and T2DM is limited. We thought to examine the association between dietary intakes of iron, copper and zinc with risk of T2DM in Japanese population.
   Methods: A prospective study encompassing 16,160 healthy Japanese men and women aged 40-65 years in whom the associations between dietary intakes of iron, copper and zinc, determined by a validated self-administered food frequency questionnaire, with risk of 5-year cumulative incidence of validated physician-diagnosed T2DM, were evaluated by logistic regression model.
   Results: We ascertained 396 self-reported new cases of diabetes within 5-year period. Dietary intakes of iron (total and nonheme but not heme iron) and copper were positively associated with risk of T2DM; the multivariable OR in the highest versus lowest quartiles of intakes were 1.32 (1.04, 1.70; P-trend = 0.03) and 1.55 (1.13, 2.02; P-trend = 0.003), respectively. These associations were more evident in the high risk group; older, overweight, smokers and those with family history of diabetes. The dietary intake of zinc was inversely associated with risk of T2DM; the multivariable OR was 0.64 (0.54, 1.00; P-trend = 0.003), and such association was evident among younger subjects (age 40-55 years) only.
   Conclusions: Dietary intakes of iron and copper were associated with a higher risk, while dietary intake of zinc was associated with a reduced risk of T2DM in Japanese population. (C) 2017 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.
C1 [Eshak, Ehab S.; Iso, Hiroyasu] Osaka Univ, Grad Sch Med, Dept Social Med, Publ Hlth, 2-2 Yamadoka, Suita, Osaka 5650871, Japan.
   [Eshak, Ehab S.] Menia Univ, Publ Hlth & Community Med Dept, Fac Med, Al Minya, Egypt.
   [Maruyama, Koutatsu] Juntendo Univ, Grad Sch Med, Dept Publ Hlth, Tokyo, Japan.
   [Muraki, Isao] Osaka Ctr Canc & Cardiovasc Dis Prevent, Dept Cardiovasc Dis Prevent, Osaka, Japan.
   [Tamakoshi, Akiko] Hokkaido Univ, Grad Sch Med, Dept Social Med, Publ Hlth, Sapporo, Hokkaido, Japan.
C3 The University of Osaka; Egyptian Knowledge Bank (EKB); Minia
   University; Juntendo University; Hokkaido University
RP Iso, H (corresponding author), Osaka Univ, Grad Sch Med, Dept Social Med, Publ Hlth, 2-2 Yamadoka, Suita, Osaka 5650871, Japan.
EM iso@pbhel.med.osaka-u.ac.jp
RI Muraki, Isao/ACA-2312-2022
OI Muraki, Isao/0000-0003-0058-7721; Eshak, Ehab/0000-0002-3564-1938
FU Comprehensive Research on Cardiovascular and Lifestyle Related Diseases
   from the Japanese Ministry of Education, Culture, Sports, Science and
   Technology [H26-Junkankitou [Seisaku]-Ippan-001];  [61010076]; 
   [62010074];  [63010074];  [1010068];  [2151065];  [3151064];  [4151063];
   [5151069];  [6279102];  [11181101];  [17015022];  [18014011]; 
   [20014026];  [20390156]; Grants-in-Aid for Scientific Research
   [16H06277, 26293138] Funding Source: KAKEN
FX The JACC study, besides the support by Comprehensive Research on
   Cardiovascular and Lifestyle Related Diseases (H26-Junkankitou
   [Seisaku]-Ippan-001) was supported from the Japanese Ministry of
   Education, Culture, Sports, Science and Technology by Grants-in-Aid for
   Scientific Research; Grants-in-Aid for Scientific Research on Priority
   Areas of Cancer and Grants-in-Aid for Scientific Research on Priority
   Areas of Cancer Epidemiology (61010076, 62010074, 63010074, 1010068,
   2151065, 3151064, 4151063, 5151069, 6279102, 11181101, 17015022,
   18014011, 20014026, and 20390156).
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NR 42
TC 85
Z9 92
U1 1
U2 37
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0261-5614
EI 1532-1983
J9 CLIN NUTR
JI Clin. Nutr.
PD APR
PY 2018
VL 37
IS 2
BP 667
EP 674
DI 10.1016/j.clnu.2017.02.010
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA GA6ZG
UT WOS:000428483200032
PM 28285974
OA Green Published
DA 2025-06-11
ER

PT J
AU Santhekadur, PK
   Kumar, DP
   Sanyal, AJ
AF Santhekadur, Prasanna K.
   Kumar, Divya P.
   Sanyal, Arun J.
TI Preclinical models of non-alcoholic fatty liver disease
SO JOURNAL OF HEPATOLOGY
LA English
DT Review
DE Non-alcoholic fatty liver disease; Non-alcoholic steatohepatitis;
   Fibrosis; NAFLD activity score; Transcriptome; Mouse models; Preclinical
   models
ID ACID-DEFINED DIET; CHOLINE-DEFICIENT; ANIMAL-MODELS; INSULIN-RESISTANCE;
   HEPATIC STEATOSIS; OXIDATIVE STRESS; METABOLIC SYNDROME; NUTRITIONAL
   MODEL; MOUSE MODELS; MURINE MODEL
AB Non-alcoholic fatty liver disease (NAFLD) can manifest as non-alcoholic fatty liver (NAFL) or non-alcoholic steatohepatitis (NASH). NASH is often associated with progressive fibrosis which can lead to cirrhosis and hepatocellular carcinoma (HCC). NASH is increasing as an aetiology for end-stage liver disease as well as HCC. There are currently no approved therapies for NASH. A major barrier to development of therapeutics for NASH is the lack of preclinical models of disease that are appropriately validated to represent the biology and outcomes of human disease. Many in vitro and animal models have been developed. In vitro models do not fully capture the hepatic and extrahepatic milieu of human NASH and large animal models are expensive and logistically difficult to use. Therefore, there is considerable interest in the development and validation of mouse models for NAFLD, including NASH. Several models based on varying genetic or dietary manipulations have been developed. However, the majority do not recreate steatohepatitis, strictly defined as the presence of hepatocellular ballooning with or without Mallory-Denk bodies, accompanied by inflammation in the presence of macrovesicular steatosis. Others lack validation against human disease. Herein, we describe the best practices in development of mouse models of NASH. We further review existing models and the literature supporting their use as a surrogate for human disease. Finally, data on models to evaluate protective genes are discussed. It is hoped that this review will provide guidance for the interpretation of data derived from mouse models and also for the development and validation of newer models. (C) 2017 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
C1 [Santhekadur, Prasanna K.; Kumar, Divya P.; Sanyal, Arun J.] Virginia Commonwealth Univ, Sch Med, Dept Internal Med, Div Gastroenterol Hepatol & Nutr, Richmond, VA USA.
C3 Virginia Commonwealth University
RP Sanyal, AJ (corresponding author), MCV Box 980341, Richmond, VA 23298 USA.
EM arun.sanyal@vcuhealth.org
RI Santhekadur, Prasanna/O-7006-2019; P. Kumar, Divya/P-2759-2019;
   Santhekadur, Prasanna K./D-2998-2012
OI P. Kumar, Divya/0000-0001-5935-379X; Santhekadur, Prasanna
   K./0000-0003-3338-375X
FU National Institutes of Health - United States of America [RO1 DK081450,
   T3207150-40]
FX This work was supported by National Institutes of Health - United States
   of America, Grants RO1 DK081450 and T3207150-40 to Arun J. Sanyal.
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NR 73
TC 278
Z9 294
U1 9
U2 193
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0168-8278
EI 1600-0641
J9 J HEPATOL
JI J. Hepatol.
PD FEB
PY 2018
VL 68
IS 2
BP 230
EP 237
DI 10.1016/j.jhep.2017.10.031
PG 8
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA FU6KU
UT WOS:000423962300002
PM 29128391
OA Green Accepted
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Liu, JJ
   Raynal, S
   Bailbé, D
   Gausseres, B
   Carbonne, C
   Autier, V
   Movassat, J
   Kergoat, M
   Portha, B
AF Liu, J. J.
   Raynal, S.
   Bailbe, D.
   Gausseres, B.
   Carbonne, C.
   Autier, V.
   Movassat, J.
   Kergoat, M.
   Portha, B.
TI Expression of the kynurenine pathway enzymes in the pancreatic islet
   cells. Activation by cytokines and glucolipotoxicity
SO BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
LA English
DT Article
DE Kynurenine pathway; IFN-gamma; IL-1 beta; Glucolipotoxicity; beta-cells;
   Non beta-cells
ID CENTRAL-NERVOUS-SYSTEM; INDOLEAMINE 2,3-DIOXYGENASE;
   TRYPTOPHAN-METABOLISM; QUINOLINIC ACID; CEREBROSPINAL-FLUID;
   INTERFERON-GAMMA; BETA-CELLS; T-CELL; INFLAMMATORY CYTOKINES; BIPOLAR
   DISORDER
AB The tryptophan/kynurenine pathway (TKP) is the main route of ttyptophan degradation and generates several neuroactive and immunomodulatory metabolites. Experimental and clinical data have clearly established that besides fat, muscle and liver, pancreatic islet tissue itself is a site of inflammation during obesity and type 2 diabetes. Therefore it is conceivable that pancreatic islet exposure to increased levels of cytokines may induce upregulation of islet kynurenine metabolism in a way resembling that seen in the brain in many neurodegenerative disorders. Using normal rat islets and the INS-I beta-cell line, we have demonstrated for the first time that: I/ only some TKP genes are constitutively expressed, both in beta-cells as well as non beta-cells; 2/ the regulatory enzyme indoleamine 2,3-dioxygenase (ID01) is not constitutively expressed; beta IDOI and kynurenine 3-monoxygenase (KMO) expression are potently activated by proinflammatory cytokines IL-113) and glucolipotoxicity respectively, rather in 13-cells than in non beta-cells; beta Islet lcynurenine/kynurenic acid production ratio is enhanced following IFN-gamma and glucolipotoxicity; 3/ acute exposure to KYN potentiates glucose-induced insulin secretion by normal islets; and 6/ oxidative stress or glucocorticoid modulates TKP genes only marginally. Pancreatic islets may represent a new target tissue for inflammation and glucolipotoxicity to activate the TKP. Since inflammation is now recognized as a crucial mechanism in the development of the metabolic syndrome and more specifically at the islet level, it is needed to evaluate the potential induction of the TKP in the endocrine pancreas during obesity and/or diabetes and its relationship to the islet cell functional alterations. 0 2015 Elsevier B.V. All rights reserved.
C1 [Liu, J. J.; Bailbe, D.; Gausseres, B.; Movassat, J.; Portha, B.] UnivParisDiderot, Sorbonne Paris Cite, Lab Biol & Pathol Pancreas Endocrin B2PE, Unite BFA Biol Fonct & Adapt,CNRS UMR CNRS 8251, Paris, France.
   [Liu, J. J.; Raynal, S.; Carbonne, C.; Autier, V.; Kergoat, M.] MetaBrain Res, Chilly Mazarin, France.
C3 Universite Paris Cite; Centre National de la Recherche Scientifique
   (CNRS); CNRS - National Institute for Biology (INSB)
RP Portha, B (corresponding author), Univ Paris Diderot, CNRS UMR 8251, Lab B2PE, Unite BFA,UMR 8251, Batiment BUFFON,5eme Etage,4, F-75205 Paris 13, France.
EM portha@univ-paris-diderot.fr
RI Movassat, Jamileh/JDV-7316-2023; Portha, Bernard/AAW-3021-2021
FU French ANRT [2011/1223]; Metabrain Research; CNRS; University
   Paris-Diderot
FX JJL is recipient of a doctoral fellowship from the French ANRT
   (convention CIFRE no. 2011/1223). The present study was supported by
   Metabrain Research (JJL, SR, CC, VA, MK), the CNRS and the University
   Paris-Diderot (JJL, DB, BG, JM, BP).
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NR 53
TC 53
Z9 55
U1 0
U2 15
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0925-4439
EI 0006-3002
J9 BBA-MOL BASIS DIS
JI Biochim. Biophys. Acta-Mol. Basis Dis.
PD MAY
PY 2015
VL 1852
IS 5
BP 980
EP 991
DI 10.1016/j.bbadis.2015.02.001
PG 12
WC Biochemistry & Molecular Biology; Biophysics; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Cell Biology
GA CG3JJ
UT WOS:000353176200027
PM 25675848
OA Bronze
DA 2025-06-11
ER

PT J
AU Picklo, MJ
   Thyfault, JP
AF Picklo, Matthew J.
   Thyfault, John P.
TI Vitamin E and vitamin C do not reduce insulin sensitivity but inhibit
   mitochondrial protein expression in exercising obese rats
SO APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
LA English
DT Article
DE insulin resistance; mitochondria; antioxidants; glucose tolerance;
   biogenesis; ascorbic acid; tocopherol
ID NICOTINAMIDE NUCLEOTIDE TRANSHYDROGENASE; SKELETAL-MUSCLE MITOCHONDRIAL;
   HIGH-FAT DIET; WEIGHT-LOSS; OXIDATIVE STRESS; ADIPOSE-TISSUE;
   ASCORBIC-ACID; METABOLIC SYNDROME; PHYSICAL-ACTIVITY; FOOD-INTAKE
AB Controversy exists as to whether supplementation with the antioxidants vitamin E and vitamin C blocks adaptation to exercise. Exercise is a first-line means to treat obesity and its complications. While diet-induced obesity alters mitochondrial function and induces insulin resistance (IR), no data exist as to whether supplementation with vitamin E and vitamin C modify responses to exercise in pre-existing obesity. We tested the hypothesis that dietary supplementation with vitamin E (0.4 g alpha-tocopherol acetate/kg) and vitamin C (0.5 g/kg) blocks exercise-induced improvements on IR and mitochondrial content in obese rats maintained on a high-fat (45% fat energy (en)) diet. Diet-induced obese, sedentary rats had a 2-fold higher homeostasis model assessment of insulin resistance and larger insulin area under the curve following glucose tolerances test than rats fed a low-fat (10% fat en) diet. Exercising (12 weeks at 5 times per week in a motorized wheel) of obese rats normalized IR indices, an effect not modified by vitamin E and vitamin C. Vitamin E and vitamin C supplementation with exercise elevated mtDNA content in adipose and skeletal muscle to a greater extent (20%) than exercise alone in a depot-specific manner. On the other hand, vitamin C and vitamin E decreased exercise-induced increases in mitochondrial protein content for complex I (40%) and nicotinamide nucleotide transhydrogenase (35%) in a muscle-dependent manner. These data indicate that vitamin E and vitamin C supplementation in obese rodents does not modify exercise-induced improvements in insulin sensitivity but that changes in mitochondrial biogenesis and mitochondrial protein expression may be modified by antioxidant supplementation.
C1 [Picklo, Matthew J.] ARS, USDA, Grand Forks Human Nutr Res Ctr, Grand Forks, ND 58201 USA.
   [Thyfault, John P.] Univ Missouri, Dept Nutr & Exercise Physiol & Med, Div Gastroenterol & Hepatol, Columbia, MO 65212 USA.
C3 United States Department of Agriculture (USDA); University of Missouri
   System; University of Missouri Columbia
RP Picklo, MJ (corresponding author), ARS, USDA, Grand Forks Human Nutr Res Ctr, 2420 2nd Ave North, Grand Forks, ND 58201 USA.
EM matthew.picklo@ars.usda.gov
RI Thyfault, John/JMB-3070-2023
OI Thyfault, John/0000-0001-7920-7466
FU USDA-ARS [5450-51000-048-00D]; NIH [RO1DK088940]
FX The authors thank Joseph Idso, Kim Michelsen, and Brian Gregoire for
   their excellent technical assistance. Funding was provided through
   USDA-ARS Project 5450-51000-048-00D. The U.S. Department of Agriculture,
   Agricultural Research Service, Plains Area, is an equal
   opportunity/affirmative action employer and all agency services are
   available without discrimination. Salary support for J.P.T. was funded
   by NIH RO1DK088940. Mention of trade names or commercial products in
   this article is solely for providing specific information and does not
   imply recommendation or endorsement by the USDA.
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NR 70
TC 30
Z9 32
U1 1
U2 10
PU CANADIAN SCIENCE PUBLISHING
PI OTTAWA
PA 65 AURIGA DR, SUITE 203, OTTAWA, ON K2E 7W6, CANADA
SN 1715-5312
EI 1715-5320
J9 APPL PHYSIOL NUTR ME
JI Appl. Physiol. Nutr. Metab.
PD APR
PY 2015
VL 40
IS 4
DI 10.1139/apnm-2014-0302
PG 10
WC Nutrition & Dietetics; Physiology; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics; Physiology; Sport Sciences
GA CE6ME
UT WOS:000351949800005
PM 25761734
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Ornello, R
   Ripa, P
   Pistoia, F
   Degan, D
   Tiseo, C
   Carolei, A
   Sacco, S
AF Ornello, Raffaele
   Ripa, Patrizia
   Pistoia, Francesca
   Degan, Diana
   Tiseo, Cindy
   Carolei, Antonio
   Sacco, Simona
TI Migraine and body mass index categories: a systematic review and
   meta-analysis of observational studies
SO JOURNAL OF HEADACHE AND PAIN
LA English
DT Article
DE Migraine; Obesity; Body mass index
ID CARDIOVASCULAR RISK-FACTORS; INSULIN-RESISTANCE; LIFE-STYLE; OBESITY
   EPIDEMIOLOGY; POSSIBLE MECHANISMS; METABOLIC SYNDROME; OXIDATIVE STRESS;
   WEIGHT-GAIN; HEADACHE; POPULATION
AB Background: Several studies have assessed the associations between migraine and underweight, pre-obesity or obesity, with conflicting results. To assess the consistency of the data on the topic, we performed a systematic review and meta-analysis of the available observational studies.
   Methods: Multiple electronic databases were systematically searched up to October 2014 for studies assessing the association between migraine and body mass index categories (underweight, pre-obesity, or obesity).
   Results: Out of 2,022 records, we included 15 studies. When considering the 11 studies following the World Health Organization BMI cutoffs, we found an increased risk of having migraine in underweight subjects (pooled adjusted effect estimate [PAEE] 1.21; 95% CI, 1.07-1.37; P = 0.002) and in obese women (PAEE 1.44; 95% CI, 1.05-1.97; P = 0.023) as compared with normal weight subjects; additionally, pre-obese subjects had an increased risk of having chronic migraine (PAEE 1.39; 95% CI, 1.13-1.71; P = 0.002). When considering all the 15 studies, we additionally found an increased risk of having migraine in obese as compared with normal weight subjects (PAEE 1.14; 95% CI, 1.02-1.27; P = 0.017); additionally, obese subjects had an increased risk of having chronic migraine (PAEE 1.75; 95% CI, 1.33-2.29; P < 0.001). The pooled analysis did not indicate an increased risk of having migraine in pre-obese subjects.
   Conclusions: The meta-analysis of the available observational studies suggested an association between migraine and obesity likely mediated by gender and migraine frequency. Further studies taking into account gender, migraine type, frequency, activity, and duration could provide more robust evidence.
C1 [Ornello, Raffaele; Ripa, Patrizia; Pistoia, Francesca; Degan, Diana; Tiseo, Cindy; Carolei, Antonio; Sacco, Simona] Univ Aquila, Inst Neurol, Dept Appl Clin Sci & Biotechnol, I-67100 Laquila, Italy.
C3 University of L'Aquila
RP Sacco, S (corresponding author), Univ Aquila, Inst Neurol, Dept Appl Clin Sci & Biotechnol, I-67100 Laquila, Italy.
EM simona.sacco@yahoo.com
RI Tiseo, Cindy/AAC-1025-2019; PISTOIA, Francesca/AAC-1027-2019; Ornello,
   Raffaele/AAS-6876-2020; Sacco, Simona/I-5253-2012
OI Degan, Diana/0000-0002-2469-409X; Tiseo, Cindy/0000-0002-8050-5142;
   Ornello, Raffaele/0000-0001-9501-4031; Sacco,
   Simona/0000-0003-0651-1939; PISTOIA, Francesca/0000-0003-0790-4240
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NR 76
TC 89
Z9 95
U1 0
U2 7
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1129-2369
EI 1129-2377
J9 J HEADACHE PAIN
JI J. Headache Pain
PD MAR 28
PY 2015
VL 16
AR 27
DI 10.1186/s10194-015-0510-z
PG 14
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA CF8LJ
UT WOS:000352810900001
PM 25903159
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Abildgaard, J
   Henstridge, DC
   Pedersen, AT
   Langley, KG
   Scheele, C
   Pedersen, BK
   Lindegaard, B
AF Abildgaard, Julie
   Henstridge, Darren C.
   Pedersen, Anette T.
   Langley, Katherine G.
   Scheele, Camilla
   Pedersen, Bente Klarlund
   Lindegaard, Birgitte
TI In Vitro Palmitate Treatment of Myotubes from Postmenopausal
   Women Leads to Ceramide Accumulation, Inflammation and Affected Insulin
   Signaling
SO PLOS ONE
LA English
DT Article
ID SKELETAL-MUSCLE CELLS; ACTIVATED PROTEIN-KINASE; METABOLIC SYNDROME;
   ENERGY-EXPENDITURE; OXIDATIVE STRESS; FAT OXIDATION;
   CARDIOVASCULAR-DISEASE; LIPID DEPOSITION; GLUCOSE-UPTAKE; RESISTANCE
AB Menopause is associated with an increased incidence of insulin resistance and metabolic diseases. In a chronic palmitate treatment model, we investigated the role of skeletal muscle fatty acid exposure in relation to the metabolic deterioration observed with menopause. Human skeletal muscle satellite cells were isolated from premenopausal (n = 6) and postmenopausal (n = 5) women. In an in vitro model, the myotubes were treated with palmitate (300 mu M) for one-, two-or three days during differentiation. Effects on lipid accumulation, inflammation and insulin signaling were studied. Palmitate treatment led to a 108% (CI 95%: 50%; 267%) increase in intramyocellular ceramide in the myotubes from the postmenopausal women (post-myotubes) compared with a 26% (CI 95%: -57%; 96%) increase in myotubes from the premenopausal women (pre-myotubes), (p<0.05). Furthermore, post-myotubes had a 22% (CI 95%: 4%; 34%) increase in pJNK (p = 0.04) and a 114% (CI 95%: 50%; 177%) increase in Hsp70 protein expression (p = 0.03) after three days of palmitate treatment, compared with pre-myotubes, in which no increase in either pJNK (-12% (CI 95: -26%; 2%)) or Hsp70 (7% (CI 95: -78%; 91%)) was detected. Furthermore, post-myotubes showed a blunted insulin stimulated phosphorylation of AS160 in response to chronic palmitate treatment compared with pre-myotubes (p = 0.02). The increased intramyocellular ceramide content in the post-myotubes was associated with a significantly higher mRNA expression of Serine Palmitoyltransferase1 (SPT1) after one day of palmitate treatment (p = 0.03) in post-myotubes compared with pre-myotubes. Our findings indicate that post-myotubes are more prone to develop lipid accumulation and defective insulin signaling following chronic saturated fatty acid exposure as compared to pre-myotubes.
C1 [Abildgaard, Julie; Scheele, Camilla; Pedersen, Bente Klarlund; Lindegaard, Birgitte] Ctr Inflammat & Metab, Copenhagen, Denmark.
   [Abildgaard, Julie; Scheele, Camilla; Pedersen, Bente Klarlund; Lindegaard, Birgitte] Ctr Phys Act Res, Dept Infect Dis, Copenhagen, Denmark.
   [Abildgaard, Julie; Scheele, Camilla; Pedersen, Bente Klarlund; Lindegaard, Birgitte] CMRC, Copenhagen, Denmark.
   [Henstridge, Darren C.; Langley, Katherine G.] Baker IDI Heart & Diabet Inst, Cellular & Mol Metab Lab, Melbourne, Vic, Australia.
   [Pedersen, Anette T.] Rigshosp, Dept Gynaecol, DK-2100 Copenhagen, Denmark.
C3 Baker Heart and Diabetes Institute; University of Copenhagen; Copenhagen
   University Hospital; Rigshospitalet
RP Lindegaard, B (corresponding author), Ctr Inflammat & Metab, Copenhagen, Denmark.
EM birgitte.lindegaard@rh.regionh.dk
RI Pedersen, Bente/AGR-3217-2022; Abildgaard, Julie/ABB-2325-2020; Scheele,
   Camilla/AAA-3599-2020; Lindegaard, Birgitte/AGY-9629-2022; Scheele,
   Camilla/S-6401-2017
OI Abildgaard, Julie/0000-0003-1317-7051; Lindegaard,
   Birgitte/0000-0002-5236-8427; Scheele, Camilla/0000-0002-6055-9709;
   Pedersen, Bente Klarlund/0000-0001-6508-6288
FU Danish National Research Foundation [DNRF55]; Trygfonden;
   Augustinusfonden; Danish Ministry of Science, Technology, and
   Innovation; Danish Council for Strategic Research [09-067009,
   09-075724]; Capital Region of Denmark
FX The Centre of Inflammation and Metabolism (CIM) is supported by a grant
   from the Danish National Research Foundation (DNRF55). The Centre for
   Physical Activity Research is supported by a grant from Trygfonden. This
   study was further supported by grants from Augustinusfonden. CIM is part
   of the UNIK Project: Food, Fitness & Pharma for Health and Disease,
   supported by the Danish Ministry of Science, Technology, and Innovation.
   CIM is a member of DD2 - the Danish Center for Strategic Research in
   Type 2 Diabetes (the Danish Council for Strategic Research, grant no.
   09-067009 and 09-075724). The Copenhagen Muscle Research Centre is
   supported by a grant from the Capital Region of Denmark. The funders had
   no role in study design, data collection and analysis, decision to
   publish, or preparation of the manuscript.
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NR 54
TC 15
Z9 16
U1 0
U2 3
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JUL 7
PY 2014
VL 9
IS 7
AR e101555
DI 10.1371/journal.pone.0101555
PG 11
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA AK7WB
UT WOS:000338637300055
PM 25000528
OA gold, Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Latif, W
   Karaboyas, A
   Tong, L
   Winchester, JF
   Arrington, CJ
   Pisoni, RL
   Marshall, MR
   Kleophas, W
   Levin, NW
   Sen, A
   Robinson, BM
   Saran, R
AF Latif, Walead
   Karaboyas, Angelo
   Tong, Lin
   Winchester, James F.
   Arrington, Charlotte J.
   Pisoni, Ronald L.
   Marshall, Mark R.
   Kleophas, Werner
   Levin, Nathan W.
   Sen, Ananda
   Robinson, Bruce M.
   Saran, Rajiv
TI Uric Acid Levels and All-Cause and Cardiovascular Mortality in the
   Hemodialysis Population
SO CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
LA English
DT Article
ID CHRONIC KIDNEY-DISEASE; REVERSE EPIDEMIOLOGY; OXIDATIVE STRESS;
   RISK-FACTOR; METABOLIC SYNDROME; DIALYSIS OUTCOMES; PRACTICE PATTERNS;
   HYPERTENSION; DEATH; HOMOCYSTEINE
AB Background and objectives Hyperuricemia is associated with hypertension, coronary artery disease, and chronic kidney disease. However, there are no specific data on the relationship of uric acid to cardiovascular disease in the chronic hemodialysis setting.
   Design, setting, participants, & measurements Data from 5827 patients on chronic hemodialysis from six countries affiliated with the Dialysis Outcomes and Practice Patterns Study (DOPPS) were analyzed. All laboratory data were based upon the initial cross-section of patients in DOPPS I and II. Cox regression was used to calculate the hazard ratio (HR) of all-cause and cardiovascular (CV) mortality with adjustments for case-mix including 14 classes of comorbidity.
   Results There were no clinically significant differences in baseline characteristics between those who had measured uric acid (n = 4637) and those who did not (n = 1190). Uric acid level was associated with lower all-cause mortality (HR: 0.95, 95% confidence interval [CI]: 0.90 to 1.00 per 1 mg/dl higher uric acid level) and CV mortality (HR: 0.92, 95% Cl: 0.86 to 0.99). When analyzed as a dichotomous variable, the adjusted HR at uric acid <= 8.2 mg/dl compared with >8.2 mg/dl was 1.24 (95% Cl: 1.03 to 1.49) for all-cause mortality and 1.54 (95% Cl: 1.15 to 2.07) for CV mortality.
   Conclusions Higher uric acid levels were associated with lower risk of all-cause and CV mortality in the hemodialysis population. These results are in contrast to the association of hyperuricemia with higher cardiovascular risk in the general population and should be the subject of further research. Clin J Am Soc Nephrol 6: 2470-2477, 2011. doi: 10.2215/CJN.00670111
C1 [Saran, Rajiv] Univ Michigan, Dept Internal Med, Div Nephrol, Ann Arbor, MI 48109 USA.
   [Latif, Walead; Winchester, James F.] Albert Einstein Coll Med, Beth Israel Med Ctr, New York, NY USA.
   [Karaboyas, Angelo; Tong, Lin; Arrington, Charlotte J.; Pisoni, Ronald L.; Robinson, Bruce M.] Arbor Res Collaborat Hlth, Ann Arbor, MI USA.
   [Marshall, Mark R.] Middlemore Hosp, Auckland 6, New Zealand.
   [Kleophas, Werner] Gemeinschaftspraxis Karlstr, Dusseldorf, Germany.
   [Levin, Nathan W.] Renal Res Inst, New York, NY USA.
C3 University of Michigan System; University of Michigan; Harvard
   University; Harvard University Medical Affiliates; Beth Israel Deaconess
   Medical Center; Yeshiva University; Arbor Research Collaborative for
   Health; Renal Research Institute
RP Saran, R (corresponding author), Univ Michigan, Dept Internal Med, Div Nephrol, 1415 Washington Hts,Suite 3645A,SPH 1, Ann Arbor, MI 48109 USA.
EM rsaran@umich.edu
RI Marshall, Mark/K-5751-2019; Marcelli, Daniele/J-3544-2016
OI Marshall, Mark Roger/0000-0003-0499-4527; Beil,
   Charlotte/0000-0001-5742-1541; Robinson, Bruce/0000-0003-0749-1714
FU Amgen; Kyowa Hakko Kirin in Japan; Genzyme; Abbott
FX The DOPPS is administered by Arbor Research Collaborative for Health and
   is supported by scientific research grants from Amgen (since 1996),
   Kyowa Hakko Kirin (since 1999, in Japan), Genzyme (since 2009), and
   Abbott (since 2009), without restrictions on publications.
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NR 33
TC 106
Z9 109
U1 0
U2 6
PU AMER SOC NEPHROLOGY
PI WASHINGTON
PA 1725 I ST, NW STE 510, WASHINGTON, DC 20006 USA
SN 1555-9041
EI 1555-905X
J9 CLIN J AM SOC NEPHRO
JI Clin. J. Am. Soc. Nephrol.
PD OCT
PY 2011
VL 6
IS 10
BP 2470
EP 2477
DI 10.2215/CJN.00670111
PG 8
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 830KX
UT WOS:000295657000021
PM 21868616
OA Bronze, Green Accepted, Green Published
DA 2025-06-11
ER

PT J
AU Gustafsson, PE
   Janlert, U
   Theorell, T
   Hammarström, A
AF Gustafsson, Per E.
   Janlert, Urban
   Theorell, Tores
   Hammarstrom, Anne
TI Is body size at birth related to circadian salivary cortisol levels in
   adulthood? Results from a longitudinal cohort study
SO BMC PUBLIC HEALTH
LA English
DT Article
ID CARDIOVASCULAR RISK-FACTORS; ADRENAL AXIS ACTIVITY; METABOLIC SYNDROME;
   FETAL ENVIRONMENT; PRETERM BIRTH; WEIGHT; DISEASE; OBESITY; STRESS;
   HYPERTENSION
AB Background: The hypothesis of fetal origins of adult disease has during the last decades received interest as an explanation of chronic, e. g. cardiovascular, disease in adulthood stemming from fetal environmental conditions. Early programming and enduring dysregulations of the hypothalamic-pituitary-adrenal (HPA axis), with cortisol as its end product, has been proposed as a possible mechanism by which birth weight influence later health status. However, the fetal origin of the adult cortisol regulation has been insufficiently studied. The present study aims to examine if body size at birth is related to circadian cortisol levels at 43 years.
   Methods: Participants were drawn from a prospective cohort study (n = 752, 74.5%). Salivary cortisol samples were collected at four times during one day at 43 years, and information on birth size was collected retrospectively from delivery records. Information on body mass during adolescence and adulthood and on health behavior, medication and medical conditions at 43 years was collected prospectively by questionnaire and examined as potential confounders. Participants born preterm or < 2500 g were excluded from the main analyses.
   Results: Across the normal spectrum, size at birth (birth weight and ponderal index) was positively related to total (area under the curve, AUC) and bedtime cortisol levels in the total sample. Results were more consistent in men than in women. Descriptively, participants born preterm or < 2500 g also seemed to display elevated evening and total cortisol levels. No associations were found for birth length or for the cortisol awakening response (CAR).
   Conclusions: These results are contradictory to previously reported negative associations between birth weight and adult cortisol levels, and thus tentatively question the assumption that only low birth weight predicts future physiological dysregulations.
C1 [Gustafsson, Per E.; Janlert, Urban; Hammarstrom, Anne] Umea Univ, Dept Publ Hlth & Clin Med, Umea, Sweden.
   [Theorell, Tores] Stockholm Univ, Stress Res Inst, S-10691 Stockholm, Sweden.
C3 Umea University; Stockholm University
RP Gustafsson, PE (corresponding author), Umea Univ, Dept Publ Hlth & Clin Med, Umea, Sweden.
EM Per.E.Gustafsson@fammed.umu.se
RI Gustafsson, Per/AAY-5068-2021; Hammarström, Anne/HNI-3080-2023
OI Hammarstrom, Anne/0000-0002-4095-7961; Gustafsson, Per
   E/0000-0002-3972-5362
FU Swedish Research Council; Swedish Council for Working Life and Social
   Research
FX Data collection at age 43 was funded by The Swedish Research Council and
   by The Swedish Council for Working Life and Social Research. The funding
   bodies had no role in study design; in collection, analysis or
   interpretation of the data; or in writing or submission of the
   manuscript. We also wish to express our gratitude to all the
   participants in the study.
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NR 44
TC 13
Z9 13
U1 0
U2 7
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-2458
J9 BMC PUBLIC HEALTH
JI BMC Public Health
PD JUN 17
PY 2010
VL 10
AR 346
DI 10.1186/1471-2458-10-346
PG 10
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA 650KL
UT WOS:000281848100001
PM 20553630
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Bruce, KD
   Cagampang, FR
   Argenton, M
   Zhang, JL
   Ethirajan, PL
   Burdge, GC
   Bateman, AC
   Clough, GF
   Poston, L
   Hanson, MA
   McConnell, JM
   Byrne, CD
AF Bruce, Kimberley D.
   Cagampang, Felino R.
   Argenton, Marco
   Zhang, Junlong
   Ethirajan, Priya L.
   Burdge, Graham C.
   Bateman, Adrian C.
   Clough, Geraldine F.
   Poston, Lucilla
   Hanson, Mark A.
   McConnell, Josie M.
   Byrne, Christopher D.
TI Maternal High-Fat Feeding Primes Steatohepatitis in Adult Mice
   Offspring, Involving Mitochondrial Dysfunction and Altered Lipogenesis
   Gene Expression
SO HEPATOLOGY
LA English
DT Article
ID NONALCOHOLIC STEATOHEPATITIS; INSULIN-RESISTANCE; LIVER-DISEASE;
   RESPIRATORY-CHAIN; HEPATIC STEATOSIS; ATP HOMEOSTASIS; OBESITY;
   PREVALENCE; DIET; ABNORMALITIES
AB Nonalcoholic fatty liver disease (NAFLD) describes an increasingly prevalent spectrum of liver disorders associated with obesity and metabolic syndrome. It is uncertain why steatosis occurs in some individuals, whereas nonalcoholic steatohepatitis (NASH) occurs in others. We have generated a novel mouse model to test our hypothesis: that maternal fat intake contributes to the development of NAFLD in adult offspring. Female mice were fed either a high-fat (HF) or control chow (C) diet before and during gestation and lactation. Resulting offspring were fed either a C or a HF diet after weaning, to generate four offspring groups; HF/HF, HF/C, C/HF, C/C. At 15 weeks of age, liver histology was normal in both the C/C and HF/C offspring. Kleiner scoring showed that although the C/HF offspring developed nonalcoholic fatty liver, the HF/HF offspring developed NASH. At 30 weeks, histological analysis and Kleiner scoring showed that both the HF/C and C/HF groups had NAFLD, whereas the HF/HF had a more severe form of NASH. Therefore, exposure to a HF diet in utero and during lactation contributes toward NAFLD progression. We investigated the mechanisms by which this developmental priming is mediated. At 15 weeks of age, hepatic mitochondrial electron transport chain (ETC) enzyme complex activity (I, II/III, and IV) was reduced in both groups of offspring from HF-fed mothers (HF/C and HF/HF). In addition, measurement of hepatic gene expression indicated that lipogenesis, oxidative stress, and inflammatory pathways were up-regulated in the 15-week-old HF/C and HF/HF offspring. Conclusion: Maternal fat intake contributes toward the NAFLD progression in adult offspring, which is mediated through impaired hepatic mitochondrial metabolism and up-regulated hepatic lipogenesis. (HEPATOLOGY 2009;50:1796-1808.)
C1 [Bruce, Kimberley D.] Univ Southampton, Southampton Gen Hosp, Inst Dev Sci, DOHaD Div, Southampton SO16 6YD, Hants, England.
   [Argenton, Marco; Poston, Lucilla; McConnell, Josie M.] Kings Coll London, Div Reprod & Endocrinol, Maternal & Fetal Res Unit, London WC2R 2LS, England.
   [Zhang, Junlong] Univ Warwick, Sch Med, Univ Hosp, Clin Sci Res Inst, Coventry CV4 7AL, W Midlands, England.
   [Bateman, Adrian C.] Southampton Gen Hosp, Histopathol Unit, Southampton SO9 4XY, Hants, England.
C3 University of Southampton; University of London; King's College London;
   University of Warwick; University of Southampton
RP Bruce, KD (corresponding author), Univ Southampton, Southampton Gen Hosp, Inst Dev Sci, DOHaD Div, Mailpoint 887,Tremona Rd, Southampton SO16 6YD, Hants, England.
EM kdb@soton.ac.uk
RI Cagampang, Felino/AAG-5141-2019; Hanson, Mark/AAE-8236-2019; Zhang,
   Jun-Long/E-9906-2013; Burdge, Graham/A-2370-2014
OI Cagampang, Felino Ramon/0000-0003-4404-9853; Byrne, Christopher
   D/0000-0001-6322-7753; Burdge, Graham/0000-0002-7665-2967; Poston,
   Lucilla/0000-0003-1100-2821; Hanson, Mark/0000-0002-6907-613X
FU UK Biotechnology and Biological Sciences Research Council; BBSRC
   [BB/D001633/1] Funding Source: UKRI
FX Supported by a Grant from the UK Biotechnology and Biological Sciences
   Research Council awarded to C. D. B.
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NR 42
TC 364
Z9 399
U1 2
U2 59
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0270-9139
EI 1527-3350
J9 HEPATOLOGY
JI Hepatology
PD DEC
PY 2009
VL 50
IS 6
BP 1796
EP 1808
DI 10.1002/hep.23205
PG 13
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 527BI
UT WOS:000272340600016
PM 19816994
OA Bronze
DA 2025-06-11
ER

PT J
AU Kotani, K
   Sakane, N
   Sano, Y
   Tsuzaki, K
   Matsuoka, Y
   Egawa, K
   Yoshimura, M
   Horikawa, C
   Kitagawa, Y
   Kiso, Y
   Kimura, S
   Schulze, J
   Taing, J
   Gugliucci, A
AF Kotani, Kazuhiko
   Sakane, Naoki
   Sano, Yoshiko
   Tsuzaki, Kokoro
   Matsuoka, Yukiyo
   Egawa, Kahori
   Yoshimura, Makiko
   Horikawa, Chika
   Kitagawa, Yoshinori
   Kiso, Yoshinobu
   Kimura, Satoshi
   Schulze, John
   Taing, Jennifer
   Gugliucci, Alejandro
TI Changes on the Physiological Lactonase Activity of Serum Paraoxonase 1
   by a Diet Intervention for Weight Loss in Healthy Overweight and Obese
   Women
SO JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION
LA English
DT Article
DE low caloric diet; low-density lipoprotein; high-density lipoprotein;
   weight reduction; BMI
ID HIGH-DENSITY-LIPOPROTEIN; OXIDATIVE STRESS; METABOLIC SYNDROME;
   CHOLESTEROL CONCENTRATIONS; INSULIN SENSITIVITY; CARDIOVASCULAR RISK;
   GENE POLYMORPHISMS; EXERCISE; LIPIDS; ASSOCIATION
AB Low caloric diet (LCD) is used for weight loss. Paraoxonase 1 (PON-1) is associated with the antioxidant functions of high-density lipoprotein (HDL). Among limited data on the relationships between obesity and PON-1, there has been no study on the effects of a standalone LCD on the physiological lactonase activity of PON-1. We investigated the prospective effects of LCD intervention (2 months) for weight loss on serum PON-1 activities (lactonase, arylesterase [mono-esterase] and tri-esterase) and HDL cholesterol (HDL-C), and their association with low-density lipoprotein cholesterol (LDL-C) in overweight and non-morbidly obese but otherwise healthy women (n = 30; mean age, 50.3 years; mean body mass index [BMI], 28.5 kg/m(2)). In addition to the data such as BMI, blood pressure, blood glucose and lipids, PON-1 activities were examined between pre- and post-intervention. The intervention reduced all metabolic outcomes, and PON-1 lactonase activity (determined with 5-[thiobutyl]butyrolactone) significantly decreased by 6.1%, paralleled by arylesterase (by 7.3%) and tri-esterase (by 7.8%). In multiple regression analysis, the percent change of PON-1 lactonase was significantly, positively and independently correlated to that of LDL-C (beta = 0.51), HDL-C (beta = 0.40), and BMI (beta = 0.37). Our results showed that the solo diet treatment on weight loss might reduce serum PON-1 lactonase activity with reduced HDL-C and LDL-C. The relationship between the lactonase and LDL-C may be adaptive, plausibly hypothesizing less need for PON-1 activity as an antioxidant property to protect lipoproteins. Further research is needed to confirm this prediction.
C1 [Kotani, Kazuhiko; Sakane, Naoki; Sano, Yoshiko; Tsuzaki, Kokoro; Matsuoka, Yukiyo] Natl Hosp Org, Clin Res Inst Endocrine & Metab Dis, Div Prevent Med, Kyoto Med Ctr, Kyoto 6128555, Japan.
   [Egawa, Kahori; Yoshimura, Makiko; Horikawa, Chika; Kitagawa, Yoshinori; Kiso, Yoshinobu] Suntory Ltd, Res Ctr, Inst Hlth Care Sci, Osaka 6180024, Japan.
   [Kimura, Satoshi] Showa Univ, No Yokohama Hosp, Dept Lab Med, Yokohama, Kanagawa 2248503, Japan.
   [Schulze, John; Taing, Jennifer; Gugliucci, Alejandro] Touro Univ Calif, Glycat Oxidat & Dis Lab, Vallejo, CA 94592 USA.
   [Kimura, Satoshi] Showa Univ, No Yokohama Hosp, Cent Clin Lab, Yokohama, Kanagawa 2248503, Japan.
C3 Suntory Holdings Ltd; Showa University; Touro University California;
   Showa University
RP Kotani, K (corresponding author), Natl Hosp Org, Clin Res Inst Endocrine & Metab Dis, Div Prevent Med, Kyoto Med Ctr, Kyoto 6128555, Japan.
EM kazukotani@jichi.ac.jp
RI Horikawa, Chika/MBG-7140-2025; Kiso, Yoshinobu/D-5424-2012
FU Ministry of education, Culture, Sports, Science, and Technology of Japan
FX This study was supported in part by a Grant-in-Aid for Scientific
   Research from the Ministry of education, Culture, Sports, Science, and
   Technology of Japan (K.K. and S.K.). The authors are grateful to Prof.
   Dan Tawfik, Department of Biological Chemistry, Weizrnann Institute of
   Science, Rehovot, Israel for kindly providing us with TBBL reagent, Dr.
   Jacques Toyal-Dope for critical reading of the manuscript and to Ms
   Claire Trias for editorial assistance.
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NR 36
TC 24
Z9 26
U1 0
U2 1
PU JOURNAL CLINICAL BIOCHEMISTRY & NUTRITION
PI KYOTO
PA KYOTO PREFECTURAL UNIV MED, GRAD SCH MEDICAL SCIENCE, DEPT MOLECULAR
   GASTROENTEROLOGY & HEPATOLOGY, KYOTO, 602-8566, JAPAN
SN 0912-0009
EI 1880-5086
J9 J CLIN BIOCHEM NUTR
JI J. Clin. Biochem. Nutr.
PD NOV
PY 2009
VL 45
IS 3
BP 329
EP 334
DI 10.3164/jcbn.09-26
PG 6
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 546FK
UT WOS:000273796300010
PM 19902024
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Rajendran, S
   Willoughby, SR
   Chan, WPA
   Liberts, EA
   Heresztyn, T
   Saha, M
   Marber, MS
   Norman, RJ
   Horowitz, JD
AF Rajendran, Sharmalar
   Willoughby, Scott R.
   Chan, Wai Ping A.
   Liberts, Elizabeth A.
   Heresztyn, Tamila
   Saha, Mrinal
   Marber, Michael S.
   Norman, Robert J.
   Horowitz, John D.
TI Polycystic ovary syndrome is associated with severe platelet and
   endothelial dysfunction in both obese and lean subjects
SO ATHEROSCLEROSIS
LA English
DT Article
DE Polycystic ovary syndrome; Platelets; Endothelial function; Nitric oxide
ID ACUTE CORONARY SYNDROMES; NITRIC-OXIDE; INSULIN-RESISTANCE; PROGENITOR
   CELLS; ARTERY-DISEASE; CARDIOVASCULAR RISK; METABOLIC SYNDROME; STABLE
   ANGINA; SYNDROME PCOS; YOUNG-WOMEN
AB Platelet hyporesponsiveness to the anti-aggregatory effects of nitric oxide (NO) occurs commonly in association with myocardial ischemia and coronary risk factors, often co-exists with endothelial dysfunction and represents an independent marker of long-term cardiovascular risk. We sought to determine whether polycystic ovary syndrome (PCOS), which has been postulated as a cardiovascular risk factor in women, is independently associated with this phenomenon. Twenty-four young women with PCOS (mean age 32.1 +/- 13) were evaluated in lean (n = 12) and obese (n = 12) subgroups, and compared with age-matched lean normals (n = 12). Platelet aggregation and its inhibition by the nitric oxide donor sodium nitroprusside (SNP) were assessed and compared with vascular endothelial function. Plasma concentrations of malondialdehyde (MDA), N-G,N-G-dimethyl-L-arginine (ADMA) and hs-CRP were measured as markers of oxidative stress, endothelial dysfunction and inflammation, respectively. Circulating endothelial progenitor cell (EPC) counts were also documented. In both PCOS subgroups, which demonstrated hyperaggregability to ADP, responses to SNP inhibition of aggregation (the principal end-point of the study) were significantly impaired (P<0.01 for both), as were their endothelium-dependent vascular responses to salbutamol (P<0.05 for both). However, vasomotor responses to nitroglycerin and circulating EPC counts did not vary between groups. PCOS subjects also had significantly elevated ADMA, MDA and hs-CRP levels relative to normals (all P<0.05). Impairment of SNIP response remained unaltered after mean 30 +/- 2.4 months follow-up in PCOS subjects. We conclude that in PCOS subjects, independent of obesity and associated insulin resistance, profound and reproducible impairment of platelet responsiveness to NO is an additional component of cardiovascular homeostatic disturbance. (C) 2008 Elsevier Ireland Ltd, All rights reserved.
C1 [Rajendran, Sharmalar; Willoughby, Scott R.; Chan, Wai Ping A.; Liberts, Elizabeth A.; Heresztyn, Tamila; Horowitz, John D.] Univ Adelaide, Queen Elizabeth Hosp, Cardiol Unit, Basil Hetzel Inst,Dept Med, Woodville, SA 5011, Australia.
   [Norman, Robert J.] Univ Adelaide, Queen Elizabeth Hosp, Res Ctr Reprod Hlth, Dept Obstet & Gynaecol, Woodville, SA 5011, Australia.
   [Saha, Mrinal; Marber, Michael S.] Kings Coll London, Div Cardiovasc, Rayne Inst, St Thomas Hosp, London, England.
C3 University of Adelaide; Basil Hetzel Institute; University of Adelaide;
   University of London; King's College London; Guy's & St Thomas' NHS
   Foundation Trust
RP Horowitz, JD (corresponding author), Univ Adelaide, Queen Elizabeth Hosp, Cardiol Unit, Basil Hetzel Inst,Dept Med, Woodville, SA 5011, Australia.
EM john.horowitz@adelaide.edu.au
RI marber, michael/AAW-7916-2021; Norman, Robert/A-1155-2007
OI Norman, Robert/0000-0002-3118-3896; Marber, Michael/0000-0002-3463-7128;
   Liberts, Elizabeth/0000-0002-7322-123X; Horowitz,
   John/0000-0001-6883-0703
FU National Health and Medical Research Council grant
FX SR, WPAC and EAL were recipients of postgraduate research scholarships
   from the University of Adelaide. This work is partially supported by a
   National Health and Medical Research Council grant.
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NR 39
TC 86
Z9 87
U1 0
U2 6
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0021-9150
EI 1879-1484
J9 ATHEROSCLEROSIS
JI Atherosclerosis
PD JUN
PY 2009
VL 204
IS 2
BP 509
EP 514
DI 10.1016/j.atherosclerosis.2008.09.010
PG 6
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 460PW
UT WOS:000267200600033
PM 19027116
DA 2025-06-11
ER

PT J
AU Piestrzeniewicz, K
   Luczak, K
   Komorowski, J
   Jankiewicz-Wika, J
   Goch, JH
AF Piestrzeniewicz, Katarzyna
   Luczak, Katarzyna
   Komorowski, Jan
   Jankiewicz-Wika, Joanna
   Goch, Jan Henryk
TI Relation of C-reactive protein to obesityr adipose tissue hormones and
   cardiovascuLar risk factors in men treated with earLy percutaneous
   intervention in course of acute myocardial infarction
SO NEUROENDOCRINOLOGY LETTERS
LA English
DT Article
DE C-reactive protein; obesity; adipokines; myocardial infarction
ID TUMOR-NECROSIS-FACTOR; CORONARY-ARTERY-DISEASE; RECIPROCAL ASSOCIATION;
   SYSTEMIC INFLAMMATION; STRESS HYPERGLYCEMIA; ADIPONECTIN LEVELS; PLASMA
   LEPTIN; SERUM LEPTIN; NITRIC-OXIDE; FACTOR-ALPHA
AB Adipose tissue appears to be a key regulator of CRP levels. C-reactive protein (CRP), a marker of systemic inflammation, predicts the occurrence of diabetes, the metabolic syndrome and atherosclerotic diseases. Adipokines, the proteins produced by adipocytes are additional factors thought to be involved in the chronic, subclinical inflammatory state of adiposity. AIM: The aim of the study was to assess the impact of obesity on the blood CRP levels and the relation of CRP to coronary risk factors and adipokines in men with acute myocardial infarction (AMI).
   METHODS: The study was performed in 37 obese (BMI >= 30) and 33 lean patients (BMI < 25) with first AMI treated with percutaneous coronary intervention within the initial 6 hours of AMI Clinical data, anthropometric measurements, biochemical parameters and blood adipokines concentration were analyzed.
   RESULTS: Values of the following parameters were significantly higher in obese than in lean patients: CRP, fasting glucose, glucose at admission, leptin and resistin, whereas HDL-cholesterol and adiponectin levels were lower. In univariate regression analysis CRP was related to obesity, HDL-cholesterol, fasting glucose, glucose at admission and adipokines but only glucose at admission and resistin were the independent positive factors and adiponectin an independent negative factor associated with CRP levels (R-2= 51.1%).
   CONCLUSIONS: In the early stage of AMI inflammation is more pronounced in obese than in lean patients. The pleiotropic association between CRP and obesity, adipokines and cardiovascular risk factors might prove it to be an important link between inflammatory reaction and atherogenesis in which adipose tissue hormones are involved.
C1 Med Univ Lodz, Dept Cardiol & Cardiosurg 1, PL-91425 Lodz, Poland.
   Med Univ Lodz, Dept Endocrinol, Lodz, Poland.
C3 Medical University Lodz; Medical University Lodz
RP Piestrzeniewicz, K (corresponding author), Med Univ Lodz, Dept Cardiol & Cardiosurg 1, 1-3,Sterling St, PL-91425 Lodz, Poland.
EM kpiestrzeniewicz@gazeta.pl
RI Komorowski, Jan/AAP-1685-2020
OI Piestrzeniewicz, Katarzyna/0000-0002-5415-2670
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NR 48
TC 8
Z9 9
U1 0
U2 0
PU MAGHIRA & MAAS PUBLICATIONS
PI MUNSBACH
PA MAGHIRA & MAAS S A R L, 6C, RUE GABRIEL LIPPMANN, L-5365 MUNSBACH,
   LUXEMBOURG
SN 0172-780X
EI 2354-4716
J9 NEUROENDOCRINOL LETT
JI Neuroendocrinol. Lett.
PD AUG
PY 2007
VL 28
IS 4
BP 427
EP 432
PG 6
WC Endocrinology & Metabolism; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology
GA 222JI
UT WOS:000250291900015
PM 17693973
DA 2025-06-11
ER

PT J
AU Cho, Y
   Chang, Y
   Ryu, S
   Wild, SH
   Byrne, CD
AF Cho, Yoosun
   Chang, Yoosoo
   Ryu, Seungho
   Wild, Sarah H.
   Byrne, Christopher D.
TI Baseline and change in serum uric acid level over time and resolution of
   nonalcoholic fatty liver disease in young adults: The Kangbuk Samsung
   Health Study
SO DIABETES OBESITY & METABOLISM
LA English
DT Article
DE changes in serum uric acid; cohort study; nonalcoholic fatty liver
   disease; serum uric acid; young adults
ID HOMEOSTASIS MODEL ASSESSMENT; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   OXIDATIVE STRESS; UNITED-STATES; HYPERURICEMIA; INFLAMMATION;
   ASSOCIATION; GLUCOSE; RISK
AB Aims: To determine the association between: (i) baseline serum uric acid (SUA) level and (ii) SUA changes over time, and nonalcoholic fatty liver disease (NAFLD) resolution. Materials and Methods: A retrospective cohort study, comprising 38 483 subjects aged <40 years with pre-existing NAFLD, was undertaken. The effects of SUA changes over time were studied in 25 266 subjects. Participants underwent a health examination between 2011 and 2019, and at least one follow-up liver ultrasonography scan up to December 2020. Exposures included baseline SUA level and SUA changes between baseline and subsequent visits, categorized into quintiles. The reference group was the third quintile (Q3) containing zero change. The primary endpoint was resolution of NAFLD. Results: During a median follow-up of 4 years, low baseline SUA level and decreases in SUA levels over time were independently associated with NAFLD resolution (p for trend <0.001). Using SUA as a continuous variable, the likelihood of NAFLD resolution was increased by 10% and 13% in men and women, respectively, per 1-mg/dL decrease in SUA. In a time-dependent model with changes in SUA treated as a time-varying covariate, adjusted hazard ratios (95% confidence intervals) for NAFLD resolution comparing Q1 (highest decrease) and Q2 (slight decrease) to Q3 (reference) were 1.63 (1.49-1.78) and 1.23 (1.11-1.35) in men and 1.78 (1.49-2.12) and 1.18 (0.95-1.46) in women, respectively. Conclusions: Low baseline SUA levels and a decrease in SUA levels over time were both associated with NAFLD resolution in young adults.
C1 [Cho, Yoosun; Chang, Yoosoo; Ryu, Seungho] Sungkyunkwan Univ, Ctr Cohort Studies, Total Healthcare Ctr, Kangbuk Samsung Hosp,Sch Med, Seoul, South Korea.
   [Cho, Yoosun] Chung Ang Univ, Coll Med, Dept Family Med, Gwangmyeong Hosp, Gwangmyeong, South Korea.
   [Chang, Yoosoo; Ryu, Seungho] Sungkyunkwan Univ, Kangbuk Samsung Hosp, Dept Occupat & Environm Med, Sch Med, Seoul, South Korea.
   [Chang, Yoosoo; Ryu, Seungho] Sungkyunkwan Univ, Samsung Adv Inst Hlth Sci & Technol, Dept Clin Res Design & Evaluat, Seoul, South Korea.
   [Chang, Yoosoo; Ryu, Seungho] Sungkyunkwan Univ, Kangbuk Samsung Hosp, Healthcare Data Ctr, Sch Med, Seoul, South Korea.
   [Wild, Sarah H.] Univ Edinburgh, Usher Inst, Edinburgh, Scotland.
   [Byrne, Christopher D.] Univ Southampton, Fac Med, Nutr & Metab, Southampton, England.
   [Byrne, Christopher D.] Univ Hosp Southampton, Natl Inst Hlth, Southampton, England.
   [Byrne, Christopher D.] Univ Hosp Southampton, Care Res Southampton Biomed Res Ctr, Southampton, South Korea.
   [Chang, Yoosoo; Ryu, Seungho] Sungkyunkwan Univ, Kangbuk Samsung Hosp, Dept Occupat & Environm Med, Sch Med, Samsung Main Bldg B2,250 Taepyung Ro 2ga, Seoul 04514, South Korea.
C3 Sungkyunkwan University (SKKU); Samsung Medical Center; Chung Ang
   University; Chung Ang University Hospital; Sungkyunkwan University
   (SKKU); Samsung Medical Center; Sungkyunkwan University (SKKU); Samsung
   Medical Center; Sungkyunkwan University (SKKU); Samsung Medical Center;
   University of Edinburgh; University of Southampton; Sungkyunkwan
   University (SKKU)
RP Chang, Y; Ryu, S (corresponding author), Sungkyunkwan Univ, Kangbuk Samsung Hosp, Dept Occupat & Environm Med, Sch Med, Samsung Main Bldg B2,250 Taepyung Ro 2ga, Seoul 04514, South Korea.
EM yoosoo.chang@gmail.com; sh703.yoo@gmail.com
OI Ryu, Seungho/0000-0002-3927-8646; Byrne, Christopher
   D/0000-0001-6322-7753; Chang, Yoosoo/0000-0002-6945-9050
FU SKKU Excellence in Research Award Research Fund (Sungkyunkwan
   University, 2022) [2022]; SKKU Excellence in Research Award Research
   Fund, Sungkyunkwan University [NRF-2021R1A2C1012626]; National Research
   Foundation of Korea - Ministry of Science, ICT, and Future Planning of
   the Republic of Korea [NIHR203319]; Southampton National Institute for
   Health and Care Research Biomedical Research Centre
FX We thank our staff members at the Kangbuk Samsung Health Study for their
   hard work, dedication, and support. This study was supported by the SKKU
   Excellence in Research Award Research Fund, Sungkyunkwan University
   (2022), and the National Research Foundation of Korea funded by the
   Ministry of Science, ICT, and Future Planning of the Republic of Korea
   (NRF-2021R1A2C1012626). Christopher Byrne was supported in part by the
   Southampton National Institute for Health and Care Research Biomedical
   Research Centre (NIHR203319), UK.
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NR 50
TC 1
Z9 1
U1 4
U2 9
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1462-8902
EI 1463-1326
J9 DIABETES OBES METAB
JI Diabetes Obes. Metab.
PD MAY
PY 2024
VL 26
IS 5
BP 1644
EP 1657
DI 10.1111/dom.15466
EA FEB 2024
PG 14
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA NC3G8
UT WOS:001155760700001
PM 38303100
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Torres, RJD
   Moreto, F
   Luchini, A
   Torres, RJD
   Longo, SP
   Pinho, RA
   Nagashima, S
   de Noronha, L
   Ferron, AJT
   Silva, CCVD
   Correa, CR
   Aldini, G
   Ferreira, ALA
AF Torres, Rogil Jose de Almeida
   Moreto, Fernando
   Luchini, Andrea
   Torres, Rogerio Joao de Almeida
   Longo, Sofia Pimentel
   Pinho, Ricardo Aurino
   Nagashima, Seigo
   de Noronha, Lucia
   Ferron, Artur Junio Togneri
   Silva, Carol Cristina Vagula de Almeida
   Correa, Camila Renata
   Aldini, Giancarlo
   Ferreira, Ana Lucia Anjos
TI Carnosine supplementation and retinal oxidative parameters in a
   high-calorie diet rat model
SO BMC OPHTHALMOLOGY
LA English
DT Article
DE High-calorie diet; Carnosine; Retina; Antioxidant
ID BETA-ALANINE SUPPLEMENTATION; HISTIDINE-CONTAINING DIPEPTIDE; PROTEIN
   CARBONYLATION; MACULAR DEGENERATION; INSULIN-RESISTANCE; METABOLIC
   SYNDROME; HIGH-FAT; CONTAINING PEPTIDOMIMETICS; ANTIOXIDANT ACTIVITY;
   ADIPOSE-TISSUE
AB Background To assess oxidative effects induced by a high-calorie diet on the retina of Wistar rats and test the antioxidative effects of carnosine supplementation.Methods Wistar rats were randomly divided into the following groups: standard diet (SD), high-calorie diet (HcD), standard diet + carnosine (SD + Car), and high-calorie diet + carnosine (HcD + Car). The body weight, adiposity index, plasma glucose, total lipids, high-density lipoprotein (HDL), low-density lipoprotein (LDL), uric acid, creatinine, and triglycerides of the animals were evaluated. The retinas were analyzed for markers of oxidative stress. Hydrogen peroxide production was assessed by 2',7'-dichlorodihydrofluorescein diacetate (DCF) oxidation. The total glutathione (tGSH), total antioxidant capacity (TAC), protein carbonyl, and sulfhydryl groups of the antioxidant system were analyzed.Results TAC levels increased in the retinas of the SD + Car group compared to the SD group (p < 0.05) and in the HcD + Car group compared to the HcD group (p < 0.05). The levels of GSH and the GSSH:GSSG ratio were increased in the HcD + Car group compared to the SD + Car group (p < 0.05). An increase in the retinal carbonyl content was observed in the HcD group compared to the SD group (p < 0.05) and in the HcD + Car group compared to the SD + Car group (p < 0.05). A high-calorie diet (HcD) was also associated with a decrease in retinal sulfhydryl-type levels compared to the SD group (p < 0.05).Conclusion The results suggest that feeding a high-calorie diet to rats can promote an increase in carbonyl content and a reduction in sulfhydryl groups in their retinas. The administration of carnosine was not effective in attenuating these oxidative markers.Trial registration Animal Ethics Committee of Botucatu Medical School - Certificate number 1292/2019.
C1 [Torres, Rogil Jose de Almeida; Moreto, Fernando; Ferron, Artur Junio Togneri; Silva, Carol Cristina Vagula de Almeida; Correa, Camila Renata; Ferreira, Ana Lucia Anjos] Univ Estadual Paulista, Med Sch, Dept Internal Med, UNESP, BR-18618687 Botucatu, SP, Brazil.
   [Luchini, Andrea] Ctr Oftalmol Curitiba, Dept Ophthalmol, Curitiba, PR, Brazil.
   [Torres, Rogerio Joao de Almeida] Hosp Angelina Caron, Dept Ophthalmol, Campina Grande Do Sul, PR, Brazil.
   [Longo, Sofia Pimentel; Pinho, Ricardo Aurino; Nagashima, Seigo; de Noronha, Lucia] Pontificia Univ Catolica Parana, Sch Med, Postgrad Program Hlth Sci, Curitiba, PR, Brazil.
   [Aldini, Giancarlo] Univ Milan, Dipartimento Sci Farmaceut DISFARM, Milan, Italy.
C3 Universidade Estadual Paulista; Pontificia Universidade Catolica do
   Parana; University of Milan
RP Torres, RJD (corresponding author), Univ Estadual Paulista, Med Sch, Dept Internal Med, UNESP, BR-18618687 Botucatu, SP, Brazil.
EM rjat@terra.com.br
RI de Almeida Torres, Rogil/ABI-5697-2020; aldini, giancarlo/C-3533-2013;
   Ferron, Artur/M-5194-2017; Moreto, Fernando/I-7690-2013; Correa,
   Camila/Q-2071-2019; A. Pinho, Ricardo/G-2643-2012
OI Correa, Camila Renata/0000-0001-8493-5329; TORRES,
   ROGIL/0000-0002-4371-202X; A. Pinho, Ricardo/0000-0003-3116-4553
FU Flamma S.p.a.
FX The authors would like to thank Flamma S.p.a., Chignolo d'Isola, Italy,
   for providing the supplement Carnosine (L-carnosine) at no cost.
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NR 86
TC 0
Z9 0
U1 1
U2 5
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2415
J9 BMC OPHTHALMOL
JI BMC Ophthalmol.
PD DEC 8
PY 2023
VL 23
IS 1
AR 502
DI 10.1186/s12886-023-03255-y
PG 12
WC Ophthalmology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Ophthalmology
GA AI9E0
UT WOS:001117946100001
PM 38066465
OA gold
DA 2025-06-11
ER

PT J
AU Rooholahzadegan, F
   Arefhosseini, S
   Tutunchi, H
   Badali, T
   Khoshbaten, M
   Ebrahimi-Mameghani, M
AF Rooholahzadegan, Farnaz
   Arefhosseini, Sara
   Tutunchi, Helda
   Badali, Taghi
   Khoshbaten, Manuchehr
   Ebrahimi-Mameghani, Mehrangiz
TI The effect of DASH diet on glycemic response, meta-inflammation and
   serum LPS in obese patients with NAFLD: a double-blind controlled
   randomized clinical trial
SO NUTRITION & METABOLISM
LA English
DT Article
DE Dietary approaches to stop hypertension; Glycemic control; Inflammation;
   Lipoploysaccharides; Non-alcoholic fatty liver disease
ID NONALCOHOLIC FATTY LIVER; STOP HYPERTENSION DASH; C-REACTIVE PROTEIN;
   AMERICAN ASSOCIATION; INSULIN-RESISTANCE; METABOLIC SYNDROME; OXIDATIVE
   STRESS; BLOOD-PRESSURE; EATING PLAN; DISEASE
AB BackgroundAs dietary approaches to stop hypertension (DASH) dietary pattern has been shown to be effective in hypertension and obesity, the present study investigated the effects of following DASH diet on glycemic, meta-inflammation, lipopolysaccharides (LPS) and liver function in obese patients with non-alcoholic fatty liver disease (NAFLD).MethodsIn this double-blind controlled randomized clinical trial, 40 obese patients with NAFLD were randomly allocated into either "DASH diet" (n = 20) or calorie-restricted diet as "Control" (n = 20) group for 8 weeks. Anthropometric measures, blood pressure, glycemic response, liver enzymes, toll-like reseptor-4 (TLR-4) and monocyte chemoattractant protein (MCP-1) and LPS as well as Dixon's DASH diet index were assessed at baseline and after 8 weeks.ResultsAfter 8 weeks, although all obesity indices decreased significantly in both groups, the reduction in all anthropometric measures were significantly greater in DASH vs control group, after adjusting for baseline values and weight change. Fasting glucose level decreased in both group, however, no inter-group significant difference was found at the end of study. Nevertheless, serum levels of hemoglobin A1c (HbA1c), TLR-4, MCP-1 and LPS as well as aspartate aminotransferase (AST) decreased significantly in DASH group, after adjusting for baseline values and weight change (p < 0.001, p = 0.004, p = 0.027, p = 0.011, and p = 0.008, respectively). The estimated number needed to treats (NNTs) for one and two grade reductions in NAFLD severity following DASH diet were 2.5 and 6.67, respectively.ConclusionAdherence to DASH diet could significantly improve weight, glycemia, inflammation and liver function in obese patients with NAFLD.
C1 [Rooholahzadegan, Farnaz; Arefhosseini, Sara; Badali, Taghi] Tabriz Univ Med Sci, Student Res Comm, Tabriz, Iran.
   [Tutunchi, Helda] Tabriz Univ Med Sci, Endocrine Res Ctr, Tabriz, Iran.
   [Khoshbaten, Manuchehr] Tabriz Univ Med Sci, Fac Med, Dept Internal Med, Tabriz, Iran.
   [Ebrahimi-Mameghani, Mehrangiz] Tabriz Univ Med Sci, Fac Nutr & Food Sci, Nutr Res Ctr, Dept Biochem & Diet Therapy, Tabriz, Iran.
C3 Tabriz University of Medical Science; Tabriz University of Medical
   Science; Tabriz University of Medical Science; Tabriz University of
   Medical Science
RP Ebrahimi-Mameghani, M (corresponding author), Tabriz Univ Med Sci, Fac Nutr & Food Sci, Nutr Res Ctr, Dept Biochem & Diet Therapy, Tabriz, Iran.
EM ebrahimimamagani@tbzmed.ac.ir
RI Tutunchi, Helda/AAC-1573-2022
FU 'Research Vice-Chancellor' of Tabriz University of Medical Sciences,
   Tabriz, Iran
FX This study was funded by the 'Research Vice-Chancellor' of Tabriz
   University of Medical Sciences, Tabriz, Iran. This paper is a part of
   the data obtained from an MSc dissertation submitted to Tabriz
   University of Medical Sciences (Farnaz Rooholahzadegan).
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NR 76
TC 18
Z9 18
U1 3
U2 9
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1743-7075
J9 NUTR METAB
JI Nutr. Metab.
PD FEB 14
PY 2023
VL 20
IS 1
AR 11
DI 10.1186/s12986-023-00733-4
PG 14
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 9C6LT
UT WOS:000935527100001
PM 36788518
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Ukashi, O
   Pflantzer, B
   Barash, Y
   Klang, E
   Segev, S
   Ozeri, DJ
   Veisman, I
   Lahat, A
   Laish, I
   Kopylov, U
   Oppenheim, A
AF Ukashi, Offir
   Pflantzer, Barak
   Barash, Yiftach
   Klang, Eyal
   Segev, Shlomo
   Ozeri, David J.
   Veisman, Ido
   Lahat, Adi
   Laish, Ido
   Kopylov, Uri
   Oppenheim, Amit
TI Cardiovascular Risk Factors and Physical Fitness Among Subjects with
   Asymptomatic Colonic Diverticulosis
SO DIGESTIVE DISEASES AND SCIENCES
LA English
DT Article
DE Diverticulosis; Screening colonoscopy; ASCVD; METs; Exercise performance
ID METABOLIC SYNDROME; DISEASE; PATHOGENESIS; METAANALYSIS; JAPAN
AB Background The association between diverticular disease and atherosclerotic cardiovascular disease (ASCVD) has been demonstrated previously, mainly in symptomatic subjects. Aims To evaluate 10 years cardiovascular risk, exercise performance and association to ASCVD among subjects with asymptomatic diverticulosis. Methods A retrospective cross-sectional cohort of self-referred participants in a medical screening program, who underwent a screening colonoscopy. Demographics, clinical and laboratory variables, ASCVD score, and metabolic equivalents (METs) during treadmill stress test were compared between subjects with and without diverticulosis as diagnosed on screening colonoscopy. Results 4586 participants underwent screening colonoscopy; 799 (17.4%) had diverticulosis. Among 50-69 yo participants, diverticulosis subjects had a higher ASCVD score compared to non-diverticulosis subjects. Exercise performance was comparable between the groups, across all age groups. Using logistic regression analysis, advanced age group (50-59 yo Adjusted odds ratio (AOR) [95% confidence interval (CI)] 2.57 (1.52-4.34), p < 0.001; 60-69 yo, AOR 2.87 (2.09-3.95), p < 0.001; >= 70 yo AOR 4.81 (3.23-7.15), p < 0.001; compared to < 50 yo age group), smoking [AOR 1.27 (1.05-1.55), p = 0.016], HTN [AOR 1.27 (1.03-1.56), p = 0.022], obesity [AOR 1.36 (1.06-1.74), p = 0.014] and male sex [AOR 1.29 (1.02-1.64), p = 0.036] were associated with diverticular detection during screening colonoscopy. Among males, achieving METs score >= 10 was inversely associated with diverticular detection during screening colonoscopy [AOR 0.64 (0.43-0.95), p = 0.027]. Conclusions Ten years probability for ASCVD estimated by the ASCVD score is higher among subjects with asymptomatic diverticulosis compared to subjects without diverticulosis. Improved exercise performance is demonstrated for the first time to correlate with decreased probability for diverticular disease in screening colonoscopy.
C1 [Ukashi, Offir; Veisman, Ido; Lahat, Adi; Laish, Ido; Kopylov, Uri] Sheba Med Ctr, Dept Gastroenterol, Haela 1, Ramat Gan, Israel.
   [Ukashi, Offir; Pflantzer, Barak; Ozeri, David J.; Oppenheim, Amit] Sheba Med Ctr, Dept Internal Med A, Haela 1, Ramat Gan, Israel.
   [Ukashi, Offir; Barash, Yiftach; Klang, Eyal; Segev, Shlomo; Ozeri, David J.; Veisman, Ido; Lahat, Adi; Laish, Ido; Kopylov, Uri; Oppenheim, Amit] Tel Aviv Univ, Sackler Sch Med, Tel Aviv, Israel.
   [Pflantzer, Barak] Hebrew Univ Jerusalem, Fac Med, Jerusalem, Israel.
   [Barash, Yiftach; Klang, Eyal] Sheba Med Ctr, Dept Diagnost Imaging, Ramat Gan, Israel.
   [Barash, Yiftach; Klang, Eyal] Sheba Med Ctr, DeepVis Lab, Ramat Gan, Israel.
   [Segev, Shlomo] Sheba Med Ctr, Inst Med Screening, Ramat Gan, Israel.
   [Ozeri, David J.] Sheba Med Ctr, Dept Rheumatol, Ramat Gan, Israel.
C3 Tel Aviv University; Chaim Sheba Medical Center; Tel Aviv University;
   Chaim Sheba Medical Center; Tel Aviv University; Sackler Faculty of
   Medicine; Hebrew University of Jerusalem; Chaim Sheba Medical Center;
   Tel Aviv University; Chaim Sheba Medical Center; Tel Aviv University;
   Tel Aviv University; Chaim Sheba Medical Center; Chaim Sheba Medical
   Center; Tel Aviv University
RP Ukashi, O (corresponding author), Sheba Med Ctr, Dept Gastroenterol, Haela 1, Ramat Gan, Israel.; Ukashi, O (corresponding author), Sheba Med Ctr, Dept Internal Med A, Haela 1, Ramat Gan, Israel.; Ukashi, O (corresponding author), Tel Aviv Univ, Sackler Sch Med, Tel Aviv, Israel.
EM Offir.Ukashi@sheba.health.gov.il; Barak.Pflantzer@sheba.health.gov.il;
   Yi.Barash@sheba.health.gov.il; Eyal.Klang@sheba.health.gov.il;
   Shlomo.Segev@sheba.health.gov.il; DavidJoshua.Ozeri@sheba.health.gov.il;
   ido.veisman@sheba.health.gov.il; Adi.Lahat@sheba.health.gov.il;
   Ido.Laish@sheba.health.gov.il; Uri.Kopylov@sheba.health.gov.il;
   Oppenheim.Amit@sheba.health.gov.il
RI Ukashi, Offir/LCD-6730-2024; Barash, Yiftach/MCK-5975-2025
OI Kopylov, Uri/0000-0002-7156-0588
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NR 32
TC 3
Z9 3
U1 0
U2 2
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0163-2116
EI 1573-2568
J9 DIGEST DIS SCI
JI Dig. Dis. Sci.
PD MAR
PY 2023
VL 68
IS 3
BP 902
EP 912
DI 10.1007/s10620-022-07572-y
EA JUN 2022
PG 11
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 9X8FJ
UT WOS:000810330100003
PM 35695973
DA 2025-06-11
ER

PT J
AU Wang, P
   Luo, CD
   Zhu, DJ
   Song, Y
   Cao, LF
   Luan, H
   Gao, L
   Zheng, SP
   Li, H
   Tian, G
AF Wang, Ping
   Luo, Chaodi
   Zhu, Danjun
   Song, Yan
   Cao, Lifei
   Luan, Hui
   Gao, Lan
   Zheng, Shuping
   Li, Hao
   Tian, Gang
TI Pericardial Adipose Tissue-Derived Leptin Promotes Myocardial Apoptosis
   in High-Fat Diet-Induced Obese Rats Through Janus Kinase 2/Reactive
   Oxygen Species/Na plus /K plus -ATPase Signaling Pathway
SO JOURNAL OF THE AMERICAN HEART ASSOCIATION
LA English
DT Article
DE leptin; myocardial apoptosis; Na+; K+-ATPase; obesity; paracrine;
   pericardial adipose tissue
ID PROTEIN-KINASE; NA+/K+-ATPASE; ENDOTHELIAL DYSFUNCTION; METABOLIC
   SYNDROME; CELL-CYCLE; ACTIVATION; HORMONE; PROLIFERATION; INVOLVEMENT;
   REGULATOR
AB Background Pathophysiologic mechanisms underlying cardiac structural and functional changes in obesity are complex and linked to adipocytokines released from pericardial adipose tissue (PAT) and cardiomyocyte apoptosis. Although leptin is involved in various pathological conditions, its role in paracrine action of pericardial adipose tissue on myocardial apoptosis remains unknown. This study was designed to investigate the role of PAT-derived leptin on myocardial apoptosis in high-fat diet-induced obese rats. Methods and Results Hearts were isolated from lean or high-fat diet-induced obese Wistar rats for myocardial remodeling studies. Obese rats had abnormal myocardial structure, diastolic dysfunction, greatly elevated cardiac apoptosis, enhanced cardiac fibrosis, and increased oxidative stress level. ELISA detected significantly higher than circulating leptin level in PAT of obese, but not lean, rats. Western blot and immunohistochemical analyses demonstrated increased leptin receptor density in obese hearts. H9c2 cardiomyoblasts, after being exposed to PAT-conditioned medium of obese rats, exhibited pronounced reactive oxygen species-mediated apoptosis, which was partially reversed by leptin antagonist. Moreover, leptin derived from PAT of obese rats inhibited Na+/K+-ATPase activity of H9c2 cells through stimulating reactive oxygen species, thereby activating calcium-dependent apoptosis. Pretreatment with specific inhibitors revealed that Janus kinase 2/signal transducer and activator of transcription 3 and phosphoinositide 3-kinase/protein kinase B signaling pathways were involved in leptin-induced myocardial apoptosis. Conclusions PAT-derived leptin induces myocardial apoptosis in high-fat diet-induced obese rats via activating Janus kinase 2/signal transducer and activator of transcription 3/reactive oxygen species signaling pathway and inhibiting its downstream Na+/K+-ATPase activity.
C1 [Wang, Ping; Luo, Chaodi; Zhu, Danjun; Cao, Lifei; Luan, Hui; Gao, Lan; Zheng, Shuping; Tian, Gang] Xi An Jiao Tong Univ, Affiliated Hosp 1, Dept Cardiol, Xian, Shaanxi, Peoples R China.
   [Song, Yan] Xi An Jiao Tong Univ, Affiliated Hosp 1, Dept Ultrasound, Xian, Shaanxi, Peoples R China.
   [Li, Hao] Xi An Jiao Tong Univ, Affiliated Hosp 1, Intens Care Unit, Xian, Shaanxi, Peoples R China.
C3 Xi'an Jiaotong University; Xi'an Jiaotong University; Xi'an Jiaotong
   University
RP Tian, G (corresponding author), Xi An Jiao Tong Univ, Affiliated Hosp 1, Dept Cardiovasc Med, 277 Yanta West Rd, Xian 710061, Shaanxi, Peoples R China.; Li, H (corresponding author), Xi An Jiao Tong Univ, Affiliated Hosp 1, Dept Intens Care Unit, 277 Yanta West Rd, Xian 710061, Shaanxi, Peoples R China.
EM hao.li215@xjtu.edu.cn; tiangang@xjtu.edu.cn
FU Nature Science Foundation of China [81873513, 81600574, 82070549,
   30871042]; Key Projects of Shaanxi Science and Technology Research and
   Development Plan [2018ZDXM-SF-049]; Shaanxi Science and Technology
   Research and Development Plan of International Science and Technology
   [2012 kw-40-01, 2014 JM2-8145]; Dr Li Jieshou (Academician of Chinese
   Academy of Sciences) Research Fund [LJS-201801]; First Affiliated
   Hospital of Xi'an Jiaotong University [XJTU1AF-CRF-2019-016]
FX This work was supported by grants from the Nature Science Foundation of
   China (grant Nos. 81873513, 81600574, 82070549, and 30871042), Key
   Projects of Shaanxi Science and Technology Research and Development Plan
   (No. 2018ZDXM-SF-049), Shaanxi Science and Technology Research and
   Development Plan of International Science and Technology (Nos. 2012
   kw-40-01 and 2014 JM2-8145), the Dr Li Jieshou (Academician of Chinese
   Academy of Sciences) Research Fund for Intestinal Barrier (LJS-201801),
   and the clinical research award of the First Affiliated Hospital of
   Xi'an Jiaotong University (No. XJTU1AF-CRF-2019-016).
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TC 14
Z9 14
U1 1
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
EI 2047-9980
J9 J AM HEART ASSOC
JI J. Am. Heart Assoc.
PD SEP 21
PY 2021
VL 10
IS 18
AR e021369
DI 10.1161/JAHA.121.021369
PG 20
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA US6AA
UT WOS:000697508400008
PM 34482701
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Li, J
   Bai, LT
   Wei, F
   Zhao, J
   Wang, DW
   Xiao, Y
   Yan, WT
   Wei, JP
AF Li, Jun
   Bai, Litao
   Wei, Fan
   Zhao, Jing
   Wang, Danwei
   Xiao, Yao
   Yan, Weitian
   Wei, Junping
TI Therapeutic Mechanisms of Herbal Medicines Against Insulin Resistance: A
   Review
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Review
DE herbal medicine; insulin resistance; signal transduction; pathway;
   mechanism
ID ACTIVATED PROTEIN-KINASE; TYPE-2 DIABETES-MELLITUS; PI3K/AKT SIGNALING
   PATHWAY; GLYCOGEN-SYNTHASE KINASE-3; POLYCYSTIC-OVARY-SYNDROME; FATTY
   LIVER-DISEASE; BETA-CELL FUNCTION; ENDOPLASMIC-RETICULUM STRESS;
   IMPAIRED GLUCOSE-TOLERANCE; HEPATIC LIPID-ACCUMULATION
AB Insulin resistance is a condition in which insulin sensitivity is reduced and the insulin signaling pathway is impaired. Although often expressed as an increase in insulin concentration, the disease is characterized by a decrease in insulin action. This increased workload of the pancreas and the consequent decompensation are not only the main mechanisms for the development of type 2 diabetes (T2D), but also exacerbate the damage of metabolic diseases, including obesity, nonalcoholic fatty liver disease, polycystic ovary syndrome, metabolic syndrome, and others. Many clinical trials have suggested the potential role of herbs in the treatment of insulin resistance, although most of the clinical trials included in this review have certain flaws and bias risks in their methodological design, including the generation of randomization, the concealment of allocation, blinding, and inadequate reporting of sample size estimates. These studies involve not only the single-flavored herbs, but also herbal formulas, extracts, and active ingredients. Numerous of in vitro and in vivo studies have pointed out that the role of herbal medicine in improving insulin resistance is related to interventions in various aspects of the insulin signaling pathway. The targets involved in these studies include insulin receptor substrate, phosphatidylinositol 3-kinase, glucose transporter, AMP-activated protein kinase, glycogen synthase kinase 3, mitogen-activated protein kinases, c-Jun-N-terminal kinase, nuclear factor-kappaB, protein tyrosine phosphatase 1B, nuclear factor-E2-related factor 2, and peroxisome proliferator-activated receptors. Improved insulin sensitivity upon treatment with herbal medicine provides considerable prospects for treating insulin resistance. This article reviews studies of the target mechanisms of herbal treatments for insulin resistance.
C1 [Li, Jun; Bai, Litao; Wei, Fan; Zhao, Jing; Wang, Danwei; Xiao, Yao; Yan, Weitian; Wei, Junping] China Acad Chinese Med Sci, Guanganmen Hosp, Dept Endocrinol, Beijing, Peoples R China.
   [Li, Jun] Beijing Univ Chinese Med, Grad Sch, Beijing, Peoples R China.
C3 China Academy of Chinese Medical Sciences; Guang'anmen Hospital, CACMS;
   Beijing University of Chinese Medicine
RP Wei, JP (corresponding author), China Acad Chinese Med Sci, Guanganmen Hosp, Dept Endocrinol, Beijing, Peoples R China.
EM weijunping@126.com
RI Xiao, Yao/AAM-1033-2020; Bai, Litao/C-7767-2009
OI Bai, Litao/0009-0005-5033-6949
FU Central Health Research Project [W2017BJ43]
FX This paper was supported by Central Health Research Project W2017BJ43.
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NR 277
TC 41
Z9 43
U1 3
U2 37
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD JUN 14
PY 2019
VL 10
AR 661
DI 10.3389/fphar.2019.00661
PG 25
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA ID7SY
UT WOS:000471884100002
PM 31258478
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Gao, J
   Meyer, K
   Borucki, K
   Ueland, PM
AF Gao, Jie
   Meyer, Klaus
   Borucki, Katrin
   Ueland, Per Magne
TI Multiplex Immuno-MALDI-TOF MS for Targeted Quantification of Protein
   Biomarkers and Their Proteoforms Related to Inflammation and Renal
   Dysfunction
SO ANALYTICAL CHEMISTRY
LA English
DT Article
ID C-REACTIVE PROTEIN; SERUM CYSTATIN-C; MASS-SPECTROMETRY;
   CONFORMATIONAL-CHANGES; METABOLIC SYNDROME; OXIDATIVE STRESS;
   HIGH-THROUGHPUT; HUMAN PLASMA; AMYLOID-A; CALPROTECTIN
AB Circulating proteins are widely used as biomarkers in clinical applications for the diagnosis, prediction, and treatment of numerous diseases. Immunoassays are the most common technologies for quantification of protein biomarkers and exist in various formats. Traditional immunoassays offer sensitive and fast analyses but cannot differentiate between proteoforms. Protein microheterogeneity, mainly due to post-translational modification, has been recognized as a fingerprint for different pathologies, and knowledge about proteoforms is an important step toward personalized medicine. Mass spectrometry (MS) has emerged to be a powerful technique for the characterization and quantification of proteoforms. We have established a novel four-plex immunoassay based on Matrix-Assisted Laser Desorption/Ionization Time-Of-Flight (MALDI-TOF) MS for the targeted quantification of the inflammatory markers C-reactive protein (CRP), serum amyloid A (SAA), and calprotectin (S100A8/9) and the kidney function marker cystatin C (CysC). Antibodies were covalently bound to superparamagnetic beads, which delivered robust and fast sample processing. Polyhistidine-tagged recombinant target proteins were used as internal standards for quantification. Our method identified a number of proteoforms for SAA (n = 11), S100A8/9 (n = 4) and CysC (n = 4). The assay was characterized by low limits of detection (0.01-0.06 mu g/mL) and low coefficients of variation (3.8-9.4%). Method validation demonstrated good between-assay agreement with immuno-turbidimetry (R-2 = 0.963 for CRP), ELISA (R-2 = 0.958 for SAA; R-2 = 0.913 for S100A8/9), and nephelometry (R-2 = 0.963 for CysC). The low sample consumption of 20 mu L, and the high sample throughput of 384 samples per day make this targeted immuno-MALDI approach suited for assessment of inflammatory and renal status in large cohort studies based on precious biobanks samples.
C1 [Gao, Jie; Ueland, Per Magne] Univ Bergen, Dept Clin Sci, N-5021 Bergen, Norway.
   [Ueland, Per Magne] Haukeland Hosp, Lab Clin Biochem, N-5021 Bergen, Norway.
   [Meyer, Klaus] Bevital AS, Jonas Lies Veg 87,Lab Bldg,Ninth Floor, N-5021 Bergen, Norway.
   [Borucki, Katrin] Otto von Guericke Univ, Inst Clin Chem & Pathobiochem, Leipziger Str 44, D-39120 Magdeburg, Germany.
C3 University of Bergen; University of Bergen; Haukeland University
   Hospital; Otto von Guericke University
RP Gao, J (corresponding author), Univ Bergen, Dept Clin Sci, N-5021 Bergen, Norway.
EM Jie.Gao@uib.no
RI Ueland, Per/C-7340-2013
OI Ueland, Per Magne/0000-0002-1903-0571; Gao, Jie/0000-0002-8477-5318
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NR 90
TC 35
Z9 38
U1 0
U2 55
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0003-2700
EI 1520-6882
J9 ANAL CHEM
JI Anal. Chem.
PD MAR 6
PY 2018
VL 90
IS 5
BP 3366
EP 3373
DI 10.1021/acs.analchem.7b04975
PG 8
WC Chemistry, Analytical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry
GA FY8EH
UT WOS:000427095700055
PM 29420882
DA 2025-06-11
ER

PT J
AU Mazur-Bialy, AI
   Pochec, E
AF Mazur-Bialy, Agnieszka Irena
   Pochec, Ewa
TI Vitamin B2 deficiency enhances the pro-inflammatory activity of
   adipocyte, consequences for insulin resistance and metabolic syndrome
   development
SO LIFE SCIENCES
LA English
DT Article
DE Ariboflavinosis; Adipocyte tissue; Inflammation; Obesity; Insulin
   resistance
ID FREE FATTY-ACIDS; ZYMOSAN-INDUCED PERITONITIS; RIBOFLAVIN DEFICIENCY;
   RECEPTOR SUBSTRATE-1; INCREASED EXPRESSION; OXIDATIVE STRESS; TYROSINE
   KINASE; ADIPOSE-TISSUES; SWISS MICE; IN-VIVO
AB Aims: Adipose tissue is an endocrine organ important for regulation of such physiological processes as energy metabolism or lipids homeostasis. In an obesity state, it participates in the induction of chronic systemic inflammation accompanied by pro-inflammatory cytokines and fatty acid elevation. For this reasons, adipose tissue is involved in, e.g., insulin resistance, type 2 diabetes or hyperlipidemia development. In our previous study, we have shown that riboflavin deficiency induces a pathological pro-inflammatory response of macrophages, the main component of adipose tissue. Therefore, in the current study, we investigated the alteration of the pro inflammatory activity of adipocytes.
   Main methods: The study was conducted on mouse 3T3 L1 preadipocytes differentiated to adipocyte and culture in the state of riboflavin deficiency (3.1 nM) or control condition (10.4 nM). The cell viability, adiposity and glucose uptake was assessed. Moreover, mRNA expression, as well as crucial pro-inflammatory cytokines (TNF alpha, IL-6) and adipokines (adiponectin, leptin, resistin) release and NF kappa B activation, were evaluated.
   Key findings: Results showed that riboflavin deprivation induced a significant elevation in adipocyte lipolysis and enhance obesity-related apoptosis of adipocytes. The generation of reactive oxygen species was enhanced in riboflavin-deficient adipocytes by 43%. Moreover, NF kappa B phosphorylation and the expression and release of both TNF alpha, IL-6 as well as leptin were elevated in a deficient group what was accompanied by a reduction of adiponectin level.
   Conclusion: Our study shows that riboflavin deficiency can promote the intensification of pro-inflammatory activity of adipocyte cells, leading consequently to the severity of chronic inflammation that accompanies obesity state. (C) 2017 Elsevier Inc. All rights reserved.
C1 [Mazur-Bialy, Agnieszka Irena] Jagiellonian Univ, Dept Ergon & Exercise Physiol, Fac Hlth Sci, Med Coll, Grzegorzecka 20, PL-31531 Krakow, Poland.
   [Pochec, Ewa] Jagiellonian Univ, Inst Zool & Biomed Res, Dept Glycoconjugate Biochem, Gronostajowa 9, PL-30387 Krakow, Poland.
C3 Jagiellonian University; Collegium Medicum Jagiellonian University;
   Jagiellonian University
RP Mazur-Bialy, AI (corresponding author), Jagiellonian Univ, Dept Ergon & Exercise Physiol, Fac Hlth Sci, Med Coll, Grzegorzecka 20, PL-31531 Krakow, Poland.
EM agnieszka.mazur@uj.edu.pl; ewa.pochec@uj.edu.pl
RI Mazur-Bialy, Agnieszka/I-4882-2012; Pochec, Ewa/AGF-8222-2022
OI Pochec, Ewa/0000-0002-9113-8579; Mazur-Bialy,
   Agnieszka/0000-0003-1056-8276
FU Ministry of Science and Higher Education, Poland [IP2012 000872]
FX This study was funded by Ministry of Science and Higher Education,
   Poland (grant number IP2012 000872). Particular thanks to the Department
   of Evolutionary Immunology (Jagiellonian University; Krakow) for sharing
   a laboratory space
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NR 51
TC 39
Z9 39
U1 1
U2 21
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0024-3205
EI 1879-0631
J9 LIFE SCI
JI Life Sci.
PD JUN 1
PY 2017
VL 178
BP 9
EP 16
DI 10.1016/j.lfs.2017.04.010
PG 8
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA EW4BS
UT WOS:000402447600002
PM 28414075
DA 2025-06-11
ER

PT J
AU Archer, SN
   Oster, H
AF Archer, Simon N.
   Oster, Henrik
TI How sleep and wakefulness influence circadian rhythmicity: effects of
   insufficient and mistimed sleep on the animal and human transcriptome
SO JOURNAL OF SLEEP RESEARCH
LA English
DT Article
DE circadian clock; gene expression; health; shift work; peripheral clocks;
   sleep deprivation; forced desynchrony
ID CLOCK GENE-EXPRESSION; NIGHT-SHIFT WORK; BLOOD MONONUCLEAR-CELLS;
   BREAST-CANCER RISK; C-FOS EXPRESSION; SUPRACHIASMATIC NUCLEUS; DNA
   METHYLATION; INTERNAL DESYNCHRONIZATION; PROLONGED WAKEFULNESS;
   CEREBROSPINAL-FLUID
AB The mammalian circadian system is a multi-oscillator, hierarchically organised system where a central pacemaker synchronises behavioural, physiological and gene expression rhythms in peripheral tissues. Epidemiological studies show that disruption of this internal synchronisation by short sleep and shift work is associated with adverse health outcomes through mechanisms that remain to be elucidated. Here, we review recent animal and human studies demonstrating the profound effects of insufficient and mistimed sleep on the rhythms of gene expression in central and peripheral tissues. In mice, sleep restriction leads to an 80% reduction in circadian transcripts in the brain and profound disruption of the liver transcriptome. In humans, sleep restriction leads to a 1.9% reduction in circadian transcripts in whole blood, and when sleep is displaced to the daytime, 97% of rhythmic genes become arrhythmic and one-third of all genes show changes in temporal expression profiles. These changes in mice and humans include a significant reduction in the circadian regulation of transcription and translation and core clock genes in the periphery, while at the same time rhythms within the suprachiasmatic nucleus are not disrupted. Although the physiological mediators of these sleep disruption effects on the transcriptonne have not been established, altered food intake, changes in hormones such as cortisol, and changes in body and brain temperature may play important roles. Processes and molecular pathways associated with these disruptions include metabolism, immune function, inflammatory and stress responses, and point to the molecular mechanisms underlying the established adverse health outcomes associated with short sleep duration and shift work, such as metabolic syndrome and cancer.
C1 [Archer, Simon N.] Univ Surrey, Fac Hlth & Med Sci, Surrey Sleep Res Ctr, Guildford GU2 5XH, Surrey, England.
   [Oster, Henrik] Med Univ Lubeck, Chronophysiol Grp, Dept Med 1, D-23538 Lubeck, Germany.
C3 University of Surrey; University of Lubeck
RP Archer, SN (corresponding author), Univ Surrey, Fac Hlth & Med Sci, Surrey Sleep Res Ctr, Guildford GU2 5XH, Surrey, England.
EM simon.archer@surrey.ac.uk; henrik.oster@uksh.de
RI Oster, Henrik/O-4426-2019; Oster, Henrik/D-2335-2013
OI Archer, Simon/0000-0002-9273-4647; Oster, Henrik/0000-0002-1414-7068
FU UK Biotechnology and Biological Sciences Research Council [BB/E003672/1,
   BB/F022883/1]; Air Force Office of Scientific Research
   [FA9550-08-1-0080]; German Research Foundation (DFG) [SFB-654, SFB-134,
   GRK-1957]; Volkswagen Foundation; BBSRC [BB/F022883/1, BB/E003672/1]
   Funding Source: UKRI
FX SNA has been supported by funding from the UK Biotechnology and
   Biological Sciences Research Council (BB/E003672/1 and BB/F022883/1) and
   the Air Force Office of Scientific Research (FA9550-08-1-0080). HO is
   supported by grants from the German Research Foundation (DFG; SFB-654,
   SFB-134 and GRK-1957) and a Lichtenberg fellowship from the Volkswagen
   Foundation. The authors thank Stephane Dorsaz, Sylvain Pradervand, Paul
   Franken and Mehdi Tafti for providing the data used to create Fig. 4a.
   Thanks to Carla Maller-Levet for help with Figs 4 and 5, and to Emma
   Laing for help with Fig. 7. The authors also thank the Editor for
   valuable input.
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NR 170
TC 126
Z9 139
U1 2
U2 79
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0962-1105
EI 1365-2869
J9 J SLEEP RES
JI J. Sleep Res.
PD OCT
PY 2015
VL 24
IS 5
BP 476
EP 493
DI 10.1111/jsr.12307
PG 18
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA CU9ST
UT WOS:000363886100002
PM 26059855
DA 2025-06-11
ER

PT J
AU Weiden, MD
   Kwon, S
   Caraher, E
   Berger, KI
   Reibman, J
   Rom, WN
   Prezant, DJ
   Nolan, A
AF Weiden, Michael D.
   Kwon, Sophia
   Caraher, Erin
   Berger, Kenneth I.
   Reibman, Joan
   Rom, William N.
   Prezant, David J.
   Nolan, Anna
TI Biomarkers of World Trade Center Particulate Matter Exposure: Physiology
   of Distal Airway and Blood Biomarkers that Predict FEV1
   Decline
SO SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE
LA English
DT Review
DE World Trade Center; lung injury; predictive biomarkers; obstructive
   airway disease
ID YORK-CITY FIREFIGHTERS; POSTTRAUMATIC-STRESS-DISORDER; OBSTRUCTIVE
   PULMONARY-DISEASE; LUNG-FUNCTION IMPAIRMENT; NECROSIS-FACTOR-ALPHA;
   CENTER COUGH-SYNDROME; C-REACTIVE PROTEIN; METABOLIC SYNDROME; CENTER
   DISASTER; RESPIRATORY SYMPTOMS
AB Biomarkers can be important predictors of disease severity and progression. The intense exposure to particulates and other toxins from the destruction of the World Trade Center (WTC) overwhelmed the lung's normal protective barriers. The Fire Department of New York (FDNY) cohort not only had baseline pre-exposure lung function measures but also had serum samples banked soon after their WTC exposure. This well-phenotyped group of highly exposed first responders is an ideal cohort for biomarker discovery and eventual validation. Disease progression was heterogeneous in this group in that some individuals subsequently developed abnormal lung function while others recovered. Airflow obstruction predominated in WTC-exposed patients who were symptomatic. Multiple independent disease pathways may cause this abnormal FEV1 after irritant exposure. WTC exposure activates one or more of these pathways causing abnormal FEV1 in an individual. Our hypothesis was that serum biomarkers expressed within 6 months after WTC exposure reflect active disease pathways and predict subsequent development or protection from abnormal FEV1 below the lower limit of normal known as WTC-Lung Injury (WTC-LI). We utilized a nested case cohort control design of previously healthy never smokers who sought subspecialty pulmonary evaluation to explore predictive biomarkers of WTC-LI. We have identified biomarkers of inflammation, metabolic derangement, protease/antiprotease balance, and vascular injury expressed in serum within 6 months of WTC exposure that were predictive of their FEV1 up to 7 years after their WTC exposure. Predicting future risk of airway injury after particulate exposures can focus monitoring and early treatment on a subset of patients in greatest need of these services.
C1 [Weiden, Michael D.; Kwon, Sophia; Caraher, Erin; Berger, Kenneth I.; Reibman, Joan; Rom, William N.; Nolan, Anna] NYU, Sch Med, Div Pulm Crit Care & Sleep, New York, NY 10016 USA.
   [Weiden, Michael D.; Prezant, David J.; Nolan, Anna] Fire Dept New York, Bur Hlth Serv, Brooklyn, NY USA.
   [Weiden, Michael D.; Prezant, David J.; Nolan, Anna] Fire Dept New York, Off Med Affairs, Brooklyn, NY USA.
   [Rom, William N.] NYU, Dept Environm Med, New York, NY 10016 USA.
   [Prezant, David J.] Montefiore Med Ctr, Dept Med, Div Pulm Med, Bronx, NY 10467 USA.
   [Prezant, David J.] Albert Einstein Coll Med, Bronx, NY 10467 USA.
C3 New York University; New York University; Montefiore Medical Center;
   Albert Einstein College of Medicine; Montefiore Medical Center; Albert
   Einstein College of Medicine; Yeshiva University
RP Nolan, A (corresponding author), NYU, Sch Med, Div Pulm Crit Care & Sleep, 462 1st Ave,New Bellevue,7N Room 24, New York, NY 10016 USA.
EM anna.nolan@med.nyu.edu
RI Nolan, Anna/C-2796-2012
OI Nolan, Anna/0000-0002-0631-1171; Reibman, Joan/0000-0001-7878-1511; Rom,
   William/0000-0002-8793-7028; Berger, Kenneth/0000-0003-4879-6071; Kwon,
   Sophia/0000-0003-3639-5107
FU NIH-NHLBI [K23HL084191]; NIAID [K24A1080298]; NIOSH [U10-OH008243,
   U10-OH008242]; NYU-HHC; National Center for Advancing Translational
   Sciences of the National Institutes of Health [UL1TR000038]; 
   [NIH-R01HL057879];  [UL1RR029893]; ALLCDC; NIOSH [556319,
   3U10OH008243-05S1] Funding Source: Federal RePORTER
FX This work was supported by NIH-NHLBI K23HL084191 (A. N.), NIAID
   K24A1080298 (M. D. W.), NIH-R01HL057879 (M. D. W.), and NIOSH
   (U10-OH008243, U10-OH008242) and UL1RR029893 (D. J. P.). This work was
   also partially funded by the NYU-HHC. Clinical and Translational Science
   Institute is supported in part by grant UL1TR000038 from the National
   Center for Advancing Translational Sciences of the National Institutes
   of Health.
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NR 164
TC 24
Z9 24
U1 0
U2 19
PU THIEME MEDICAL PUBL INC
PI NEW YORK
PA 333 SEVENTH AVE, NEW YORK, NY 10001 USA
SN 1069-3424
EI 1098-9048
J9 SEMIN RESP CRIT CARE
JI Semin. Respir. Crit. Care Med.
PD JUN
PY 2015
VL 36
IS 3
BP 323
EP 333
DI 10.1055/s-0035-1547349
PG 11
WC Critical Care Medicine; Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Respiratory System
GA CJ3CX
UT WOS:000355362100002
PM 26024341
OA Green Accepted
DA 2025-06-11
ER

PT J
AU McCarty, MF
AF McCarty, Mark F.
TI Potential ghrelin-mediated benefits and risks of hydrogen water
SO MEDICAL HYPOTHESES
LA English
DT Article
ID 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE MOUSE MODEL; EXPERIMENTAL
   AUTOIMMUNE ENCEPHALOMYELITIS; DETECTED CORONARY ATHEROSCLEROSIS; CHRONIC
   HEART-FAILURE; BLOOD-BRAIN-BARRIER; PARKINSONS-DISEASE; RICH WATER;
   OXIDATIVE STRESS; ALZHEIMERS-DISEASE; METABOLIC SYNDROME
AB Molecular hydrogen (H-2) can scavenge hydroxyl radical and diminish the toxicity of peroxynitrite; hence, it has interesting potential for antioxidant protection. Recently, a number of studies have explored the utility of inhaled hydrogen gas, or of hydrogen-saturated water, administered parenterally or orally, in rodent models of pathology and in clinical trials, oftentimes with very positive outcomes. The efficacy of orally ingested hydrogen-rich water (HW) has been particularly surprising, given that only transient and rather small increments in plasma hydrogen can be achieved by this method. A recent study in mice has discovered that orally administered MW provokes increased gastric production of the orexic hormone ghrelin, and that this ghrelin mediates the favorable impact of HW on a mouse model of Parkinson's disease. The possibility that most of the benefits observed with HW in experimental studies are mediated by ghrelin merits consideration. Ghrelin is well known to function as an appetite stimulant and secretagogue for growth hormone, but it influences physiological function throughout the body via interaction with the widely express GHS-R1a receptor. Rodent and, to a more limited extent, clinical studies establish that ghrelin has versatile neuroprotective and cognitive enhancing activity, favorably impacts vascular health, exerts anti-inflammatory activity useful in autoimmune disorders, and is markedly hepatoprotective. The stimulatory impact of ghrelin on GH-IGF-I activity, while potentially beneficial in sarcopenia or cachectic disorders, does raise concerns regarding the long-term impact of ghrelin up-regulation on cancer risk. The impact of ingesting MW water on ghrelin production in humans needs to be evaluated; if MW does up-regulate ghrelin in humans, it may have versatile potential for prevention and control of a number of health disorders. (c) 2015 Elsevier Ltd. All rights reserved.
C1 Catalyt Longev, Carlsbad, CA 92009 USA.
RP McCarty, MF (corresponding author), Catalyt Longev, 7831 Rush Rose Dr,Apt 316, Carlsbad, CA 92009 USA.
EM markfmccarty@gmail.com
FU Catalytic Longevity
FX Financial support provided by Catalytic Longevity, a non-profit
   organization.
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NR 122
TC 14
Z9 16
U1 0
U2 23
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0306-9877
EI 1532-2777
J9 MED HYPOTHESES
JI Med. Hypotheses
PD APR
PY 2015
VL 84
IS 4
BP 350
EP 355
DI 10.1016/j.mehy.2015.01.018
PG 6
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA CE2PE
UT WOS:000351656700013
PM 25649854
DA 2025-06-11
ER

PT J
AU O'Charoen, S
   Hayakawa, S
   Matsumoto, Y
   Ogawa, M
AF O'Charoen, Siwaporn
   Hayakawa, Shigeru
   Matsumoto, Yoshiki
   Ogawa, Masahiro
TI Effect of D-Psicose Used as Sucrose Replacer on the Characteristics of
   Meringue
SO JOURNAL OF FOOD SCIENCE
LA English
DT Article
DE d-psicose; egg white protein; meringue; sucrose; sugar replacement
ID DIETARY D-PSICOSE; RARE SUGAR; SYSTEM; MASS
AB Excessive intake of sugar-rich foods leads to metabolic syndrome. d-Psicose (Psi) not commonly found in nature, is noncalorie sweetener with a suppressive effect on the blood glucose level. Thus, Psi has the potential to be utilized as a sucrose (Suc) replacer in sugar-rich foods, including meringue-based confectionery (MBC). In this study, we investigated the effect of Psi on the physical and chemical properties of meringue. Meringue was made by whipping egg white and Suc (at a weight ratio of 1:1) and baking at 93 degrees C for 2 h. Thirty percent of the total weight of Suc was replaced with d-ketohexoses such as Psi, d-fructose, d-tagatose, and d-sorbose. The meringues containing d-ketohexoses had higher specific volume than the meringue not containing d-ketohexoses (Ct-meringue). Baking of meringue caused differences between Psi and the other d-ketohexose meringues. Meringue containing Psi (P30-meringue) had the highest breaking stress (7.00 x 10(5) N/m(2)) and breaking strain (4.40%), resulting in the crunchiest texture. In addition, P30-meringue also had the highest antioxidant activity (491.84 M TE/mg-meringue determined by ABTS method) and was the brownest due to a Maillard reaction occurring during baking. The replacement of Suc with Psi improved the characteristics of baked meringue. Thus, Psi was found to be useful in modifying the physical and chemical properties of MBC.
   Practical Application d-Psicose, a noncalorie sweetener with a suppressive effect on the blood glucose level, can be utilized as a sucrose replacer in sugar-rich foods such as meringue-based confectionery (MBC). d-Psicose creates a crunchy texture and enhances the antioxidant activity of baked meringue. Thus, d-psicose may be useful in modification of MBC.
C1 [O'Charoen, Siwaporn; Hayakawa, Shigeru; Matsumoto, Yoshiki; Ogawa, Masahiro] Kagawa Univ, Fac Agr, Dept Appl Biol Sci, Miki, Kagawa 7610795, Japan.
C3 Kagawa University
RP Hayakawa, S (corresponding author), Kagawa Univ, Fac Agr, Dept Appl Biol Sci, 2393 Ikenobe, Miki, Kagawa 7610795, Japan.
EM hayakawa@ag.kagawa-u.ac.jp
RI MATSUMOTO, Yoshiki/AAW-8516-2020; Ogawa, Masahiro/AAW-4875-2021
OI Matsumoto, Yoshiki/0000-0002-8620-2863; OGAWA,
   Masahiro/0000-0002-1549-6008
FU City Area Program, the Ministry of Education, Culture, Sports, Science
   and Technology, Japan
FX This work was partially supported by the City Area Program, the Ministry
   of Education, Culture, Sports, Science and Technology, Japan. The
   authors also thank Peter Lutes, associate professor of Faculty of
   Agriculture, Kagawa Univ., for language editing.
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NR 23
TC 40
Z9 40
U1 5
U2 80
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-1147
EI 1750-3841
J9 J FOOD SCI
JI J. Food Sci.
PD DEC
PY 2014
VL 79
IS 12
BP E2463
EP E2469
DI 10.1111/1750-3841.12699
PG 7
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA AX0PS
UT WOS:000346654800008
PM 25388824
DA 2025-06-11
ER

PT J
AU Feng, M
   Tian, L
   Gan, L
   Liu, ZJ
   Sun, C
AF Feng, Min
   Tian, Liang
   Gan, Lu
   Liu, Zhenjiang
   Sun, Chao
TI Mark4 promotes adipogenesis and triggers apoptosis in 3T3-L1 adipocytes
   by activating JNK1 and inhibiting p38MAPK pathways
SO BIOLOGY OF THE CELL
LA English
DT Article
DE adipogenesis; apoptosis; JNK1pathway; Mark4; p38MAPK pathway
ID INSULIN-RESISTANCE; OXIDATIVE STRESS; HEPATIC STEATOSIS;
   SKELETAL-MUSCLE; PROTEIN-KINASES; CYTOCHROME-C; MITOCHONDRIA;
   DYSFUNCTION; MAPK; BAX
AB Background InformationMicrotubule affinity-regulating kinase 4 (MARK4) deficiency has been reported to negatively regulate diet-induced obesity and to mitigate insulin resistance in knockout mice, and thus may play a role in metabolic syndrome. However, the details of the molecular mechanism have yet to be revealed and the impacts of MARK4 on apoptosis remain unexplored. This study investigated the role of Mark4 in the regulation of lipid accumulation and apoptosis in adipocytes and analysed signalling pathways involved.
   ResultsWe found that Mark4 significantly up-regulated the expression of gene sterol regulatory element binding protein-1c (SREBP-1c), fatty acid synthase (FAS), acetyl-CoA carboxylase- (ACC) and peroxisome proliferator activated receptor- (PPAR); and reduced the protein contents of adipose triglyceride lipase (ATGL), as evidenced by the dramatic increasing lipid droplet accumulation in 3T3-L1 cells. Furthermore, a terminal deoxynucleotidyl transferase dUTP nick end labelling (TUNEL) apoptosis assay showed that Mark4 triggered apoptosis of adipocytes; and apoptosis was confirmed by the decreased protein contents of B-cell lymphoma-2 (Bcl-2), full-length caspase-3 and full-length caspase-9, as well as the increased expression of Bax, cleaved caspase-3 and cleaved caspase-9. Analysis of special inhibitors allowed us to offer the following explanation for these impacts of Mark4: activation of Jun N-terminal kinase1 (JNK1) promoted both apoptosis and adipogenesis, whereas inhibition of the p38 mitogen-activated protein kinase (p38MAPK) pathway contributed to lipid accumulation alone.
   ConclusionsMark4 promotes adipogenesis in 3T3-L1 adipocytes by activating the JNK1 and inhibiting the p38MAPK pathway, and triggers apoptosis by activating the JNK1 pathway. We conclude that anti-Mark4 therapy targetted to inhibit lipid accumulation and apoptosis of adipocytes shows potential as a novel therapeutic strategy for treatment of obesity-associated metabolic complications.
C1 [Feng, Min; Tian, Liang; Gan, Lu; Liu, Zhenjiang; Sun, Chao] Northwest A&F Univ, Coll Anim Sci & Technol, Yangling 712100, Shaanxi, Peoples R China.
C3 Northwest A&F University - China
RP Sun, C (corresponding author), Northwest A&F Univ, Coll Anim Sci & Technol, Yangling 712100, Shaanxi, Peoples R China.
EM sunchao2775@163.com
RI Gan, Lu/JXX-1314-2024
FU National Nature Science Foundation of China [31172185]; Agriculture
   Technology Innovation in Shaanxi Province of China [2012NKC01-13]
FX This work was supported by National Nature Science Foundation of China
   (31172185) and Agriculture Technology Innovation in Shaanxi Province of
   China (2012NKC01-13).
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NR 51
TC 43
Z9 48
U1 0
U2 16
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0248-4900
EI 1768-322X
J9 BIOL CELL
JI Biol. Cell
PD SEP
PY 2014
VL 106
IS 9
BP 294
EP 307
DI 10.1111/boc.201400004
PG 14
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA AO9PV
UT WOS:000341689000002
PM 24989893
DA 2025-06-11
ER

PT J
AU Crujeiras, AB
   Zulet, MA
   Lopez-Legarrea, P
   de la Iglesia, R
   Pardo, M
   Carreira, MC
   Martínez, JA
   Casanueva, FF
AF Crujeiras, Ana B.
   Angeles Zulet, M.
   Lopez-Legarrea, Patricia
   de la Iglesia, Rocio
   Pardo, Maria
   Carreira, Marcos C.
   Alfredo Martinez, J.
   Casanueva, Felipe F.
TI Association between circulating irisin levels and the promotion of
   insulin resistance during the weight maintenance period after a dietary
   weight-lowering program in obese patients
SO METABOLISM-CLINICAL AND EXPERIMENTAL
LA English
DT Article
DE FNDC5; Hypocaloric diet; Insulin sensitivity; Weight regain
ID MESSENGER-RNA EXPRESSION; METABOLIC SYNDROME; DIABETES-MELLITUS;
   OXIDATIVE STRESS; PRECURSOR FNDC5; EXERCISE; PLASMA; MUSCLE; HEALTHY;
   HUMANS
AB Objective. Weight regain is associated with the promotion of insulin resistance. The newly discovered myokine irisin, which was proposed to be involved in the management of insulin sensitivity, could play a role in this process. This study aimed to investigate the association between irisin and reduced insulin sensitivity induced by weight regain.
   Materials/Methods. Insulin sensitivity was evaluated according to the homeostasis model assessment of insulin resistance (HOMA-IR) in 136 obese patients who followed an eight-week hypocaloric diet (30% reduced energy expenditure) to lose weight and was re-evaluated four or six months after treatment. Irisin plasma levels, as well as the levels of leptin, adiponectin, ghrelin and TNF-alpha, were quantified in a sub-cohort (n = 73) from the initially studied patients at baseline (T0), at the diet endpoint (T1) and after the follow-up period (T2).
   Results. After a successful dietary intervention to lose weight, 50% of the patients who regained the lost weight during the follow-up period were categorized as insulin resistant (HOMA-IR >= 2.5) compared with only 25% of patients who maintained the weight loss (p = 0.018). Importantly, in addition to the well-studied hormones leptin and adiponectin, irisin plasma levels were statistically associated with several risk factors for insulin resistance. Indeed, the increased risk of insulin resistance during the follow-up period was related to high irisin levels at baseline (odds ratio = 4.2; p = 0.039).
   Conclusions. Circulating irisin predicts the insulin resistance onset in association with weight regain. Therefore, irisin could be secreted as an adaptive response to counteract the deleterious effect of excess adiposity on glucose homeostasis. (C) 2014 Elsevier Inc. All rights reserved.
C1 [Crujeiras, Ana B.; Pardo, Maria; Carreira, Marcos C.; Casanueva, Felipe F.] Complejo Hosp Univ Santiago CHUS, Lab Mol & Cellular Endocrinol, Inst Invest Sanitaria IDIS, Santiago De Compostela, Spain.
   [Crujeiras, Ana B.; Pardo, Maria; Carreira, Marcos C.; Casanueva, Felipe F.] Santiago de Compostela Univ USC, Santiago De Compostela, Spain.
   [Crujeiras, Ana B.] Bellvitge Biomed Res Inst IDIBELL, Canc Epigenet & Biol Program PEBC, Barcelona, Spain.
   [Angeles Zulet, M.; Lopez-Legarrea, Patricia; de la Iglesia, Rocio; Alfredo Martinez, J.] Univ Navarra UNAV, Dpt Nutr Food Sci & Physiol, Pamplona, Spain.
   [Crujeiras, Ana B.; Angeles Zulet, M.; Lopez-Legarrea, Patricia; de la Iglesia, Rocio; Pardo, Maria; Carreira, Marcos C.; Alfredo Martinez, J.; Casanueva, Felipe F.] CIBER Fisiopatol Obesidad & Nutr CIBERobn, Madrid, Spain.
C3 Complexo Hospitalario Universitario de Santiago de Compostela;
   Universidade de Santiago de Compostela; Institut d'Investigacio
   Biomedica de Bellvitge (IDIBELL); University of Navarra; CIBER - Centro
   de Investigacion Biomedica en Red; CIBEROBN
RP Crujeiras, AB (corresponding author), Complejo Hosp Santiago CHUS, Mol & Cellular Endocrinol Area, Lab 2, Inst Invest Sanitaria, C Choupana S-N, Santiago De Compostela 15706, Spain.
EM anabelencrujeiras@hotmail.com
RI de la Iglesia, Rocio/ABC-6189-2020; Crujeiras, Ana B/ABA-8866-2021;
   Zulet, M. Angeles/H-1317-2017; Pardo, Maria/C-5124-2012; Martinez
   Hernandez, J Alfredo/K-8709-2014
OI de la Iglesia, Rocio/0000-0002-7472-3565; Crujeiras, Ana
   B/0000-0003-4392-0301; Zulet, M. Angeles/0000-0002-3926-0892; Pardo,
   Maria/0000-0002-9967-1650; Martinez Hernandez, J
   Alfredo/0000-0001-5218-6941
FU CIBERobn [CB06/03]; INTRA-SALUD project [PI10/02464]; Instituto de Salud
   Carlos III (ISCIII) initiatives; Health Department of the Government of
   Navarra [48/2009]; Linea Especial "Nutrition, Obesity and Health"
   University of Navarra [LE/97]; ISCIII [C09/00365, FI10/00587]
FX This work was supported by CIBERobn (CB06/03) and INTRA-SALUD project
   (PI10/02464), Instituto de Salud Carlos III (ISCIII) initiatives, as
   well as by the Health Department of the Government of Navarra (48/2009)
   and Linea Especial "Nutrition, Obesity and Health" (University of
   Navarra LE/97). AB. Crujeiras and R. de la Iglesia are funded by the
   ISCIII through a research contract "Sara Borrell" (C09/00365) and a
   predoctoral grant (FI10/00587), respectively. M. Pardo is a Miguel
   Servet Fellow (ISCIII/SERGAS).
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NR 60
TC 124
Z9 132
U1 0
U2 23
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0026-0495
EI 1532-8600
J9 METABOLISM
JI Metab.-Clin. Exp.
PD APR
PY 2014
VL 63
IS 4
BP 520
EP 531
DI 10.1016/j.metabol.2013.12.007
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA AE0MB
UT WOS:000333659300011
PM 24439241
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Chen, SCC
   Huang, YF
   Wang, JD
AF Chen, Solomon Chih Cheng
   Huang, Ya Fang
   Wang, Jung Der
TI Hyperferritinemia and Hyperuricemia May Be Associated with Liver
   Function Abnormality in Obese Adolescents
SO PLOS ONE
LA English
DT Article
ID HFE GENE-MUTATIONS; C VIRUS-INFECTION; FATTY LIVER; IRON DEPLETION;
   HEPATITIS-C; METABOLIC SYNDROME; OXIDATIVE STRESS; URIC-ACID; ALANINE
   AMINOTRANSFERASE; INSULIN-RESISTANCE
AB Background: The iron status in human body and its association with liver function in adolescents was rarely studied. The objective was to investigate the association among the levels of serum ferritin, uric acid and alanine aminotransferase (ALT) in adolescents.
   Methods and Results: A total of 2090 adolescents negative for hepatitis B surface antigen from one junior high school (786, 12-13 years), three senior high schools (973, 15-16 years) and one college (331, 18-19 years) participated in this survey. Anthropometric and biochemical measurements, including complete blood count, ALT, serum ferritin and uric acid were performed. An ALT>42 U/L was defined as elevated, a ferritin level >200 mu g/L was defined as hyperferritinemia. A uric acid level>460 mu mol/L in males and >340 mu mol/L in females was defined as hyperuricemia. The chi-squared test, linear regression and multivariate logistic regression were used for the data analysis. Elevated ALT levels were detected in 76 (3.6%) students and were more prevalent in males than females (6.4% vs. 2.0%, p<0.001). The univariate analysis found gender, age group, body mass index, ferritin level, uric acid level and white blood cell count all to be significantly associated with elevated ALT. Linear regression showed a positive correlation among log(ferritin), uric acid level and ALT level. Elevated ALT occurred more frequently at ferritin level >100 mu g/L. The logistic regression analysis found that body mass index, hyperferritinemia and hyperuricemia were significant factors associated with the ALT elevation, but gender, age, and white blood cell count were not.
   Conclusions: Hyperferritinemia and hyperuricemia are two independently significant factors associated with ALT elevation among obese adolescents. More studies are needed to corroborate any hypothesis related to these phenomena.
C1 [Chen, Solomon Chih Cheng] Chia Yi Christian Hosp, Dept Pediat, Chiayi, Taiwan.
   [Chen, Solomon Chih Cheng] Taipei Med Univ, Coll Med, Dept Pediat, Taipei, Taiwan.
   [Huang, Ya Fang] Pingtung Christian Hosp, Dept Clin Lab, Pingtung City, Taiwan.
   [Wang, Jung Der] Natl Cheng Kung Univ, Dept Publ Hlth, Coll Med & Hosp, Tainan 70101, Taiwan.
C3 Taipei Medical University; National Cheng Kung University
RP Chen, SCC (corresponding author), Chia Yi Christian Hosp, Dept Pediat, Chiayi, Taiwan.
EM solomon.ccc@gmail.com
RI Chen, Solomon/C-2085-2008
OI Chen, Solomon/0000-0003-0031-6147; Mou, Wenjun/0000-0002-7781-7671
FU National Science Council, Taiwan [NSC99-2314-B-475-001]
FX This study was funded by a grant (NSC99-2314-B-475-001) from the
   National Science Council, Taiwan (http://web1.nsc.gov.tw/). The funder
   had no role in study design, data collection and analysis, decision to
   publish, or preparation of the manuscript.
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NR 43
TC 13
Z9 14
U1 0
U2 9
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD OCT 31
PY 2012
VL 7
IS 10
AR e48645
DI 10.1371/journal.pone.0048645
PG 6
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 030WJ
UT WOS:000310600500188
PM 23119080
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Kim, M
   Yang, SG
   Kim, JM
   Lee, JW
   Kim, YS
   Lee, JI
AF Kim, Mina
   Yang, Su-Geun
   Kim, Joon Mi
   Lee, Jin-Woo
   Kim, Young Soo
   Lee, Jung Il
TI Silymarin suppresses hepatic stellate cell activation in a dietary rat
   model of non-alcoholic steatohepatitis: Analysis of isolated hepatic
   stellate cells
SO INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
LA English
DT Article
DE non-alcoholic steatohepatitis; methionine- and choline-deficient diet;
   insulin resistance; hepatic stellate cell; silymarin
ID FATTY LIVER-DISEASE; NF-KAPPA-B; CARBON-TETRACHLORIDE; METABOLIC
   SYNDROME; INSULIN-RESISTANCE; OXIDATIVE STRESS; HEPG2 CELLS;
   ANTIOXIDANT; EXPRESSION; MICE
AB Non-alcoholic steatohepatitis (NASH) is characterized by hepatocellular injury and initial fibrosis severity has been suggested as an important prognostic factor of NASH. Silymarin was reported to improve carbon tetrachloride-induced liver fibrosis and reduce the activation of hepatic stellate cells (HSC). We investigated whether silymarin could suppress the activation of HSCs in NASH induced by methionine- and choline-deficient (MCD) diet fed to insulin-resistant rats. NASH was induced by feeding MCD diet to obese diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) rats. Non-diabetic Long-Evans Tokushima Otsuka (LETO) rats were fed with standard chow and served as the control. OLETF rats were fed on either standard laboratory chow, or MCD diet or MCD diet mixed with silymarin. Histological analysis of the liver showed improved non-alcoholic fatty liver disease (NAFLD) activity score in silymarin-fed MCD-induced NASH. Silymarin reduced the activation of HSCs, evaluated by counting alpha-smooth muscle actin (SMA)-positive cells and measuring alpha-SMA mRNA expression in the liver lysates as well as in HSCs isolated from the experimental animals. Although silymarin decreased alpha(1)-procollagen mRNA expression in isolated HSCs, the anti-fibrogenic effect of silymarin was not prominent so as to show significant difference under histological analysis. Silymarin increased the nuclear translocation of nuclear factor erythroid 2-related factor 2 (Nrf2) and decreased tumor necrosis factor (TNF)-alpha mRNA expression in the liver. Our study suggested that the possible protective effect of silymarin in diet induced NASH by suppressing the activation of HSCs and disturbing the role of the inflammatory cytokine TNF-alpha.
C1 [Kim, Mina; Lee, Jin-Woo; Kim, Young Soo; Lee, Jung Il] Inha Univ, Sch Med, Div Gastroenterol, Dept Internal Med, Inchon 400711, South Korea.
   [Kim, Mina; Yang, Su-Geun] Utah Inha DDS & Adv Therapeut Res Ctr, Inchon, South Korea.
   [Kim, Joon Mi] Inha Univ, Sch Med, Dept Pathol, Inchon 400711, South Korea.
C3 Inha University; Inha University
RP Lee, JI (corresponding author), Inha Univ, Sch Med, Div Gastroenterol & Hepatol, Dept Internal Med, 7-206 Shinheung Dong, Inchon 400711, South Korea.
EM mdflorence@inha.ac.kr
FU National Research Foundation of Korea [331-2008-1-E00099]
FX This investigation was supported by a grant from the National Research
   Foundation of Korea, grant no. 331-2008-1-E00099.
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NR 36
TC 70
Z9 72
U1 1
U2 24
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1107-3756
EI 1791-244X
J9 INT J MOL MED
JI Int. J. Mol. Med.
PD SEP
PY 2012
VL 30
IS 3
BP 473
EP 479
DI 10.3892/ijmm.2012.1029
PG 7
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 983SQ
UT WOS:000307139400003
PM 22710359
OA hybrid, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Lee, MYK
   Li, HY
   Xiao, Y
   Zhou, ZG
   Xu, AM
   Vanhoutte, PM
AF Lee, Mary Y. K.
   Li, Huiying
   Xiao, Yang
   Zhou, Zhiguang
   Xu, Aimin
   Vanhoutte, Paul M.
TI Chronic administration of BMS309403 improves endothelial function in
   apolipoprotein E-deficient mice and in cultured human endothelial cells
SO BRITISH JOURNAL OF PHARMACOLOGY
LA English
DT Article
DE A-FABP; endothelium-dependent relaxation; eNOS; endothelial dysfunction;
   nitric oxide; atherosclerosis
ID ACID-BINDING PROTEINS; PORCINE CORONARY-ARTERIES; OXIDATIVE STRESS;
   DEPENDENT CONTRACTIONS; METABOLIC SYNDROME; DYSFUNCTION; EXPRESSION;
   ADIPOCYTE; AP2; ATHEROSCLEROSIS
AB BACKGROUND AND PURPOSE
   Adipocyte fatty acid-binding protein (A-FABP) is up-regulated in regenerated endothelial cells and modulates inflammatory responses in macrophages. Endothelial dysfunction accompanying regeneration is accelerated by hyperlipidaemia. Here, we investigate the contribution of A-FABP to the pathogenesis of endothelial dysfunction in the aorta of apolipoprotein E-deficient (ApoE-/-) mice and in cultured human endothelial cells.
   EXPERIMENTAL APPROACH
   A-FABP was measured in aortae of ApoE-/-mice and human endothelial cells by RT-PCR, immunostaining and immunoblotting. Total and phosphorylated forms of endothelial nitric oxide synthase (eNOS) were measured by immunoblotting. Changes in isometric tension were measured in rings of mice aortae
   KEY RESULTS
   A-FABP was expressed in aortic endothelium of ApoE-/- mice aged 12 weeks and older, but not at 8 weeks or in C57 wild-type mice. Reduced endothelium-dependent relaxations to acetylcholine, UK14304 (selective alpha(2)-adrenoceptor agonist) and A23187 (calcium ionophore) and decreased protein presence of phosphorylated and total eNOS were observed in aortae of 18 week-old ApoE-/- mice compared with age-matched controls. A 6 week treatment with the A-FABP inhibitor, BMS309403, started in 12 week-old mice, improved endothelial function, phosphorylated and total eNOS and reduced plasma triglyceride levels but did not affect endothelium-independent relaxations. The beneficial effect of BMS309403 on UK14304-induced relaxations was attenuated by Pertussis toxin. In cultured human microvascular endothelial cells, lipid-induced A-FABP expression was associated with reduced phosphorylated eNOS and NO production and was reversed by BMS309403.
   CONCLUSIONS AND IMPLICATIONS
   Elevated expression of A-FABP in endothelial cells contributes to their dysfunction both in vivo and in vitro.
C1 [Lee, Mary Y. K.; Xu, Aimin; Vanhoutte, Paul M.] Univ Hong Kong, Dept Pharmacol & Pharm, Li Ka Shing Fac Med, Hong Kong, Hong Kong, Peoples R China.
   [Li, Huiying; Xu, Aimin] Univ Hong Kong, Dept Med, Li Ka Shing Fac Med, Hong Kong, Hong Kong, Peoples R China.
   [Xiao, Yang; Zhou, Zhiguang] Cent S Univ, Ctr Diabet, Metab Syndrome Res Ctr, Inst Metab & Endocrinol,Xiangya Hosp 2, Changsha, Hunan, Peoples R China.
C3 University of Hong Kong; University of Hong Kong; Central South
   University
RP Vanhoutte, PM (corresponding author), Univ Hong Kong, Dept Pharmacol & Pharm, Li Ka Shing Fac Med, 21 Sassoon Rd, Hong Kong, Hong Kong, Peoples R China.
EM vanhoutt@hkucc.hku.hk
RI Lee, Mary/C-1967-2016; li, qing/JEF-9044-2023; Xu, Aimin/D-3291-2013;
   Xiao, Yang/N-5021-2017
OI Xiao, Yang/0000-0003-3927-1839; Zhou, Zhiguang/0000-0002-0374-1838
FU University of Hong Kong; Research Grant Council of Hong Kong
   [HKU200707176115, HKU7772/08 M, HKU 2/07C]; Research Centre of Heart,
   Brain, Hormone & Healthy Aging of the University of Hong Kong; NSFC/GRC
   [N_HKU 735/08]
FX This work was supported in part by grants from the Small Project Funding
   from the University of Hong Kong, the Research Grant Council of Hong
   Kong (HKU200707176115 and HKU7772/08 M), the Research Centre of Heart,
   Brain, Hormone & Healthy Aging of the University of Hong Kong, the
   Collaborative Research Fund from Research Grant Council of Hong Kong
   (HKU 2/07C), and the NSFC/GRC joint research scheme (Project No: N_HKU
   735/08).
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NR 42
TC 79
Z9 81
U1 0
U2 8
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0007-1188
EI 1476-5381
J9 BRIT J PHARMACOL
JI Br. J. Pharmacol.
PD APR
PY 2011
VL 162
IS 7
BP 1564
EP 1576
DI 10.1111/j.1476-5381.2010.01158.x
PG 13
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 730FE
UT WOS:000288018100010
PM 21175571
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Alzamendi, A
   Castrogiovanni, D
   Ortega, HH
   Gaillard, RC
   Giovambattista, A
   Spinedi, E
AF Alzamendi, Ana
   Castrogiovanni, Daniel
   Ortega, Hugo H.
   Gaillard, Rolf C.
   Giovambattista, Andres
   Spinedi, Eduardo
TI Parametrial Adipose Tissue and Metabolic Dysfunctions Induced by
   Fructose-rich Diet in Normal and Neonatal-androgenized Adult Female Rats
SO OBESITY
LA English
DT Article
ID INSULIN-RESISTANCE; OXIDATIVE STRESS; ADIPONECTIN LEVELS;
   HYPERTENSIVE-RATS; BETA-CELL; ADIPOCYTES; DYSLIPIDEMIA; SENSITIVITY;
   SECRETION; RECEPTOR
AB Hyperandrogenemia predisposes an organism toward developing impaired insulin sensitivity. The aim of our study was to evaluate endocrine and metabolic effects during early allostasis induced by a fructose-rich diet (FRD) in normal (control; CT) and neonatal-androgenized (testosterone propionate; TP) female adult rats. CT and TP rats were fed either a normal diet (ND) or an FRD for 3 weeks immediately before the day of study, which was at age 100 days. Energy intake, body weight (BW), parametrial (PM) fat characteristics, and endocrine/metabolic biomarkers were then evaluated. Daily energy intake was similar in CT and TP rats regardless of the differences in diet. When compared with CT-ND rats, the TP-ND rats were heavier, had larger PM fat, and were characterized by basal hypoadiponectinemia and enhanced plasma levels of non-esterified fatty acid (NEFA), plasminogen activator inhibitor-1 (PAI-1), and leptin. FRD-fed CT rats, when compared with CT-ND rats, had high plasma levels of NEFA, triglyceride (TG), PAI-1, leptin, and adiponectin. The TP-FRD rats, when compared with TP-ND rats, displayed enhanced leptinemia and triglyceridemia, and were hyperinsulinemic, with glucose intolerance. The PM fat taken from TP rats displayed increase in the size of adipocytes, decrease in adiponectin (protein/gene), and a greater abundance of the leptin gene. PM adipocyte response to insulin was impaired in CT-FRD, TP-ND, and TP-FRD rats. A very short duration of isocaloric FRD intake in TP rats induced severe metabolic dysfunction at the reproductive age. Our study supports the hypothesis that the early-androgenized female rat phenotype is highly susceptible to developing endocrine/metabolic dysfunction. In turn, these abnormalities enhance the risk of metabolic syndrome, obesity, type 2 diabetes, and cardiovascular disease.
C1 [Alzamendi, Ana; Castrogiovanni, Daniel; Giovambattista, Andres; Spinedi, Eduardo] IMBICE CONICET CICPBA, Neuroendocrine Unit, La Plata, Buenos Aires, Argentina.
   [Ortega, Hugo H.] Natl Univ Litoral, Ctr Expt Biol, Esperanza, Argentina.
   [Ortega, Hugo H.] Natl Univ Litoral, Lab Anim Sci, Esperanza, Argentina.
   [Gaillard, Rolf C.] CHU Vaudois, Univ Hosp, Div Endocrinol Diabetol & Metab, CH-1011 Lausanne, Switzerland.
C3 Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET);
   National University of the Littoral; National University of the
   Littoral; University of Lausanne; Centre Hospitalier Universitaire
   Vaudois (CHUV)
RP Spinedi, E (corresponding author), IMBICE CONICET CICPBA, Neuroendocrine Unit, La Plata, Buenos Aires, Argentina.
EM spinedi@imbice.org.ar
RI Spinedi, Eduardo/F-2455-2016; Ortega, Hugo/AGL-5925-2022
OI Alzamendi, Ana/0000-0003-4126-1103; Ortega, Hugo/0000-0002-7663-3133
FU FONCyT [PICT2007- 01051]; CONICET [PIP-11220080100704]; FRPE; FNSR
   [3200BO-105657/1]
FX We thank Jose Romero for his criticisms and Susan H. Rogers for
   correcting and editing the manuscript. This work was supported by FONCyT
   (PICT2007- 01051, to E. S.), CONICET (PIP-11220080100704, to E. S.),
   FRPE (2007/2009, to E. S.), and FNSR (3200BO-105657/1, to R. C. G.). It
   was presented, in part, at the 2008 Obesity Society Annual Scientific
   Meeting, New Orleans.
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NR 39
TC 18
Z9 20
U1 0
U2 7
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1930-7381
EI 1930-739X
J9 OBESITY
JI Obesity
PD MAR
PY 2010
VL 18
IS 3
BP 441
EP 448
DI 10.1038/oby.2009.255
PG 8
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 562BO
UT WOS:000275024100003
PM 19696763
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Lang, F
   Böhmer, C
   Palmada, M
   Seebohm, G
   Strutz-Seebohm, N
   Vallon, V
AF Lang, Florian
   Boehmer, Christoph
   Palmada, Monica
   Seebohm, Guiscard
   Strutz-Seebohm, Nathalie
   Vallon, Volker
TI (Patho)physiological significance of the serum- and
   glucocorticoid-inducible kinase isoforms
SO PHYSIOLOGICAL REVIEWS
LA English
DT Review
ID EPITHELIAL NA+ CHANNEL; TISSUE GROWTH-FACTOR; UBIQUITIN LIGASE NEDD4-2;
   COLLECTING DUCT CELLS; THREONINE PROTEIN-KINASE; ALDOSTERONE-INDUCED
   KINASE; MESSENGER-RNA EXPRESSION; REGULATING FACTOR NHERF2; TARGETED
   MICE LACKING; MEDULLARY K+ CHANNEL
AB (Patho)physiological Significance of the Serum- and Glucocorticoid-Inducible Kinase Isoforms. The serum- and glucocorticoid-inducible kinase-1 (SGK1) is ubiquitously expressed and under genomic control by cell stress (including cell shrinkage) and hormones (including gluco- and mineralocorticoids). Similar to its isoforms SGK2 and SGK3, SGK1 is activated by insulin and growth factors via phosphatidylinositol 3-kinase and the 3-phosphoinositide-dependent kinase PDK1. SGKs activate ion channels (e.g., ENaC, TRPV5, ROMK, Kv1.3, KCNE1/KCNQ1, GluR1, GluR6), carriers (e.g., NHE3, GLUT1, SGLT1, EAAT1-5), and the Na+-K+-ATPase. They regulate the activity of enzymes (e.g., glycogen synthase kinase-3, ubiquitin ligase Nedd4-2, phosphomannose mutase-2) and transcription factors (e.g., forkhead transcription factor FKHRL1, beta-catenin, nuclear factor kappa B). SGKs participate in the regulation of transport, hormone release, neuroexcitability, cell proliferation, and apoptosis. SGK1 contributes to Na+ retention and K+ elimination of the kidney, mineralocorticoid stimulation of salt appetite, glucocorticoid stimulation of intestinal Na+/H+ exchanger and nutrient transport, insulin-dependent salt sensitivity of blood pressure and salt sensitivity of peripheral glucose uptake, memory consolidation, and cardiac repolarization. A common (similar to 5% prevalence) SGK1 gene variant is associated with increased blood pressure and body weight. SGK1 may thus contribute to metabolic syndrome. SGK1 may further participate in tumor growth, neurodegeneration, fibrosing disease, and the sequelae of ischemia. SGK3 is required for adequate hair growth and maintenance of intestinal nutrient transport and influences locomotive behavior. In conclusion, the SGKs cover a wide variety of physiological functions and may play an active role in a multitude of pathophysiological conditions. There is little doubt that further targets will be identified that are modulated by the SGK isoforms and that further SGK-dependent in vivo physiological functions and pathophysiological conditions will be defined.
C1 Univ Tubingen, Dept Physiol, D-72076 Tubingen, Germany.
   Univ Calif San Diego, Dept Med, San Diego, CA 92103 USA.
   Univ Calif San Diego, Dept Pharmacol, San Diego, CA 92103 USA.
   San Diego Vet Affairs Healthcare Syst, San Diego, CA USA.
C3 Eberhard Karls University of Tubingen; University of California System;
   University of California San Diego; University of California System;
   University of California San Diego
RP Lang, F (corresponding author), Univ Tubingen, Dept Physiol, Gmelinstr 5, D-72076 Tubingen, Germany.
EM florian.lang@uni-tuebingen.de
OI Vallon, Volker/0000-0002-9211-2063
FU NIDDK NIH HHS [DK-56248, DK-70667] Funding Source: Medline
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NR 387
TC 598
Z9 645
U1 1
U2 72
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0031-9333
EI 1522-1210
J9 PHYSIOL REV
JI Physiol. Rev.
PD OCT
PY 2006
VL 86
IS 4
BP 1151
EP 1178
DI 10.1152/physrev.00050.2005
PG 28
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA 095JT
UT WOS:000241304700004
PM 17015487
DA 2025-06-11
ER

PT J
AU Sakhaei, R
   Shahvazi, S
   Mozaffari-Khosravi, H
   Samadi, M
   Khatibi, N
   Nadjarzadeh, A
   Zare, F
   Salehi-Abargouei, A
AF Sakhaei, Roya
   Shahvazi, Simin
   Mozaffari-Khosravi, Hassan
   Samadi, Morteza
   Khatibi, Nasim
   Nadjarzadeh, Azadeh
   Zare, Fateme
   Salehi-Abargouei, Amin
TI The Dietary Approaches to Stop Hypertension (DASH)-Style Diet and an
   Alternative Mediterranean Diet are Differently Associated with Serum
   Inflammatory Markers in Female Adults
SO FOOD AND NUTRITION BULLETIN
LA English
DT Article
DE Dietary Approaches to Stop Hypertension; Mediterranean diet;
   inflammatory markers; hs-CRP; IL-17
ID C-REACTIVE PROTEIN; VIRGIN OLIVE OIL; DASH DIET; CARDIOVASCULAR-DISEASE;
   BLOOD-PRESSURE; MULTIPLE-SCLEROSIS; INSULIN-RESISTANCE; METABOLIC
   SYNDROME; OXIDATIVE STRESS; HEALTHY-ADULTS
AB Background: Studies on the association between a priori dietary patterns and serum highly sensitive C-reactive protein (hs-CRP) have led to inconsistent results, and we are not aware of any study on interleukin 17A (IL-17A) as an inflammatory marker associated with autoimmune diseases.
   Objective: The present study aimed to investigate the association between Dietary Approaches to Stop Hypertension (DASH) and the Mediterranean dietary patterns with circulating hs-CRP and IL-17A levels.
   Methods: In this cross-sectional study, female teachers (aged 20-50 years) who lived in Yazd, Iran, were randomly selected from elementary, guidance, and high schools from September 2015 to February 2016. Anthropometric data, as well as general information and dietary food intakes, were gathered, and each participant gave 1 blood sample. Participants were categorized into tertiles based on the DASH and the Mediterranean diet calculated scores. The associations between the dietary patterns and serum hs-CRP and IL-17A levels were assessed in the crude and multivariable models. In total, 320 female teachers aged 40.38 (8.08) years were included.
   Results: The DASH diet was associated with lower serum hs-CRP levels in the crude (P = .05) and the fully adjusted models (P = .02), while it was not significantly associated with IL-17A levels. The participants with the highest adherence to the Mediterranean diet had significantly lower circulating IL-17A levels (P = .04) even controlling for all confounders (P = .02); however, there was not a significant relationship between this diet and hs-CRP levels.
   Conclusions: The DASH and the Mediterranean dietary patterns might be differently associated with inflammatory markers. Further prospective studies are recommended to confirm our results.
C1 [Sakhaei, Roya; Shahvazi, Simin; Mozaffari-Khosravi, Hassan; Khatibi, Nasim; Nadjarzadeh, Azadeh; Salehi-Abargouei, Amin] Shahid Sadoughi Univ Med Sci, Nutr & Food Secur Res Ctr, Yazd, Iran.
   [Sakhaei, Roya; Shahvazi, Simin; Mozaffari-Khosravi, Hassan; Khatibi, Nasim; Nadjarzadeh, Azadeh; Salehi-Abargouei, Amin] Shahid Sadoughi Univ Med Sci, Sch Publ Hlth, Dept Nutr, Yazd, Iran.
   [Sakhaei, Roya; Khatibi, Nasim] Shahid Sadoughi Univ Med Sci, Int Campus, Yazd, Iran.
   [Samadi, Morteza; Zare, Fateme] Shahid Sadoughi Univ Med Sci, Abort Res Ctr, Res & Clin Ctr Infertil, Yazd, Iran.
   [Samadi, Morteza; Zare, Fateme] Shahid Sadoughi Univ Med Sci, Reprod Immunol Res Ctr, Yazd, Iran.
   [Samadi, Morteza; Zare, Fateme] Shahid Sadoughi Univ Med Sci, Res Ctr Food Hyg & Safety, Yazd, Iran.
C3 Shahid Sadoughi University of Medical Sciences; Shahid Sadoughi
   University of Medical Sciences; Shahid Sadoughi University of Medical
   Sciences; Shahid Sadoughi University of Medical Sciences; Shahid
   Sadoughi University of Medical Sciences; Shahid Sadoughi University of
   Medical Sciences
RP Salehi-Abargouei, A (corresponding author), Shahid Sadoughi Univ Med Sci, Fac Hlth, Dept Nutr, Yazd 8915173160, Iran.
EM abargouei@ssu.ac.ir
RI Mozaffari-khosravi, Hassan/A-4359-2009; Zare, Fateme/AAR-1317-2021;
   samadi, morteza/AAS-7309-2021; Nadjarzadeh, Azadeh/A-8490-2017;
   Salehi-Abargouei, Amin/C-9039-2011
OI samadi, morteza/0000-0002-9220-6174; Salehi-Abargouei,
   Amin/0000-0002-7580-6717; zare, fateme/0000-0003-0436-9924
FU international campus of Shahid Sadoughi University of Medical Sciences,
   Yazd, Iran
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: This study
   was extracted from a thesis for MSc degree in nutrition and was funded
   by the international campus of Shahid Sadoughi University of Medical
   Sciences, Yazd, Iran.
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NR 69
TC 22
Z9 23
U1 4
U2 15
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0379-5721
EI 1564-8265
J9 FOOD NUTR BULL
JI Food Nutr. Bull.
PD SEP
PY 2018
VL 39
IS 3
BP 361
EP 376
DI 10.1177/0379572118783950
PG 16
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA GU4TV
UT WOS:000445278400002
PM 29969908
DA 2025-06-11
ER

PT J
AU Wang, XQ
   Zhu, YH
   Feng, CP
   Lin, G
   Wu, GY
   Li, DF
   Wang, JJ
AF Wang, Xiaoqiu
   Zhu, Yuhua
   Feng, Cuiping
   Lin, Gang
   Wu, Guoyao
   Li, Defa
   Wang, Junjun
TI Innate differences and colostrum-induced alterations of jejunal mucosal
   proteins in piglets with intra-uterine growth restriction
SO BRITISH JOURNAL OF NUTRITION
LA English
DT Article
DE Jejunum; Colostrum; Porcine neonates; Intra-uterine growth restriction;
   Proteomics
ID APOLIPOPROTEIN A-IV; ILEAL LIPID INFUSION; CELL-PROLIFERATION; FETAL
   PIGS; DIETARY SUPPLEMENTATION; INTESTINAL DEVELOPMENT; METABOLIC
   SYNDROME; NEONATAL PIGLETS; SKELETAL-MUSCLE; MOUSE MODEL
AB Mammalian neonates undergo rapid transitions from a sterile uterine environment with a continuous intravenous supply of nutrients to a microbe-rich environment with intermittent ingesting of colostrum/milk via the gut. Currently, little is known about the colostrum-induced alterations of intestinal mucosal proteins in piglets with intra-uterine growth restriction (IUGR). In this study, we sought to investigate the innate differences and effects of colostrum on alterations in small-intestinal proteomes of IUGR piglets. Two IUGR (approximately 0.9 kg) and two normal-birth weight (NBW; approximately 1.3 kg) piglets were obtained from each of six sows at birth. One half (n 12; 6 IUGR v. 6 NBW) of the selected newborn piglets were killed to obtain jejunum samples, and the other half (n 12; 6 IUGR v. 6 NBW) of the newborn piglets were allowed to suckle colostrum from their own mothers for 24 h before jejunum sample collection. On the basis of proteomic analysis, we identified thirty-one differentially expressed proteins in the jejunal mucosa between IUGR and normal neonates before or after colostrum consumption. The intestinal proteins altered by colostrum feeding play important roles in the following: (1) increasing intestinal integrity, transport of nutrients, energy metabolism, protein synthesis, immune response and, therefore, cell proliferation; and (2) decreasing oxidative stress, and therefore cell apoptosis, in IUGR neonates. However, colostrum only partially ameliorated the inferior status of the jejunal mucosa in IUGR neonates. These findings provide the first evidence in intestinal protein alterations of IUGR neonates in response to colostrum ingestion, and thus render new insights into the mechanisms responsible for impaired growth in IUGR neonates and into new nutritional intervention strategies.
C1 [Wang, Xiaoqiu; Zhu, Yuhua; Lin, Gang; Wu, Guoyao; Li, Defa; Wang, Junjun] China Agr Univ, State Key Lab Anim Nutr, Beijing 100193, Peoples R China.
   [Zhu, Yuhua; Wang, Junjun] China Agr Univ, Beijing Adv Innovat Ctr Food Nutr & Human Hlth, Beijing 100193, Peoples R China.
   [Feng, Cuiping] China Japan Friendship Hosp, Dept Obstet & Gynecol, Beijing 100029, Peoples R China.
   [Wu, Guoyao] Texas A&M Univ, Dept Anim Sci, College Stn, TX 77843 USA.
   [Wang, Xiaoqiu] NIEHS, Reprod & Dev Biol Lab, NIH, POB 12233, Res Triangle Pk, NC 27709 USA.
C3 China Agricultural University; China Agricultural University;
   China-Japan Friendship Hospital; Texas A&M University System; Texas A&M
   University College Station; National Institutes of Health (NIH) - USA;
   NIH National Institute of Environmental Health Sciences (NIEHS)
RP Wang, JJ (corresponding author), China Agr Univ, State Key Lab Anim Nutr, Beijing 100193, Peoples R China.; Wang, JJ (corresponding author), China Agr Univ, Beijing Adv Innovat Ctr Food Nutr & Human Hlth, Beijing 100193, Peoples R China.
EM jkywjj@hotmail.com
RI Lin, Gang/AAH-6873-2020; Wang, Junjun/G-8893-2011; Wang,
   Xiaoqiu/AAT-3368-2021
FU National Natural Science Foundation of China [31272449, 31422052,
   31630074]; Beijing Municipal Natural Science Foundation [S170001];
   National Key Research and Development Program of China [2016YFD0500506];
   National High Technology Research and Development Program of China
   [2013AA10230602]; '111' Project [B16044]; China Agriculture Research
   System [CARS-35]; Jinxinnong University Animal Science Developmental
   Foundation; Hunan Co-Innovation Center of Animal Production Safety,
   CICAPS
FX This present study was supported by the National Natural Science
   Foundation of China (nos 31272449, 31422052 and 31630074), the Beijing
   Municipal Natural Science Foundation (S170001), the National Key
   Research and Development Program of China (2016YFD0500506), the National
   High Technology Research and Development Program of China
   (2013AA10230602), the '111' Project (B16044), China Agriculture Research
   System (CARS-35), Jinxinnong University Animal Science Developmental
   Foundation and Hunan Co-Innovation Center of Animal Production Safety,
   CICAPS.
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Z9 32
U1 0
U2 24
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1145
EI 1475-2662
J9 BRIT J NUTR
JI Br. J. Nutr.
PD APR 14
PY 2018
VL 119
IS 7
BP 734
EP 747
DI 10.1017/S0007114518000375
PG 14
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA GE3SX
UT WOS:000431134300002
PM 29569542
OA Bronze
DA 2025-06-11
ER

PT J
AU Giricz, Z
   Koncsos, G
   Rajtík, T
   Varga, ZV
   Baranyai, T
   Csonka, C
   Szobi, A
   Adameová, A
   Gottlieb, RA
   Ferdinandy, P
AF Giricz, Zoltan
   Koncsos, Gabor
   Rajtik, Tomas
   Varga, Zoltan V.
   Baranyai, Tamas
   Csonka, Csaba
   Szobi, Adrian
   Adameova, Adriana
   Gottlieb, Roberta A.
   Ferdinandy, Peter
TI Hypercholesterolemia downregulates autophagy in the rat heart
SO LIPIDS IN HEALTH AND DISEASE
LA English
DT Article
DE Hypercholesterolemia; Autophagy; Apoptosis; Necroptosis; Programmed
   necrosis; ATG8; Caspase; Receptor-interacting serine/threonine-protein
   kinase
ID ISCHEMIA-REPERFUSION INJURY; CHOLESTEROL-RICH DIET; DIASTOLIC
   DYSFUNCTION; METABOLIC SYNDROME; OXIDATIVE STRESS; APOPTOSIS; NECROSIS;
   CARDIOPROTECTION; NECROPTOSIS; PEROXYNITRITE
AB Background: We have previously shown that efficiency of ischemic conditioning is diminished in hypercholesterolemia and that autophagy is necessary for cardioprotection. However, it is unknown whether isolated hypercholesterolemia disturbs autophagy or the mammalian target of rapamycin (mTOR) pathways. Therefore, we investigated whether isolated hypercholesterolemia modulates cardiac autophagy-related pathways or programmed cell death mechanisms such as apoptosis and necroptosis in rat heart.
   Methods: Male Wistar rats were fed either normal chow (NORM; n = 9) or with 2% cholesterol and 0.25% cholic acidenriched diet (CHOL; n = 9) for 12 weeks. CHOL rats exhibited a 41% increase in plasma total cholesterol level over that of NORM rats (4.09 mmol/L vs. 2.89 mmol/L) at the end of diet period. Animals were sacrificed, hearts were excised and briefly washed out. Left ventricles were snap-frozen for determination of markers of autophagy, mTOR pathway, apoptosis, and necroptosis by Western blot.
   Results: Isolated hypercholesterolemia was associated with a significant reduction in expression of cardiac autophagy markers such as LC3-II, Beclin-1, Rubicon and RAB7 as compared to controls. Phosphorylation of ribosomal S6, a surrogate marker for mTOR activity, was increased in CHOL samples. Cleaved caspase-3, a marker of apoptosis, increased in CHOL hearts, while no difference in the expression of necroptotic marker RIP1, RIP3 and MLKL was detected between treatments.
   Conclusions: This is the first comprehensive analysis of autophagy and programmed cell death pathways of apoptosis and necroptosis in hearts of hypercholesterolemic rats. Our data show that isolated hypercholesterolemia suppresses basal cardiac autophagy and that the decrease in autophagy may be a result of an activated mTOR pathway. Reduced autophagy was accompanied by increased apoptosis, while cardiac necroptosis was not modulated by isolated hypercholesterolemia. Decreased basal autophagy and elevated apoptosis may be responsible for the loss of cardioprotection reported in hypercholesterolemic animals.
C1 [Giricz, Zoltan; Koncsos, Gabor; Varga, Zoltan V.; Baranyai, Tamas; Ferdinandy, Peter] Semmelweis Univ, Dept Pharmacol & Pharmacotherapy, Fac Med, Nagyvarad Ter 4, H-1089 Budapest, Hungary.
   [Varga, Zoltan V.; Csonka, Csaba] Univ Szeged, Dept Biochem, Fac Med, Dom Ter 9, H-6720 Szeged, Hungary.
   [Rajtik, Tomas; Szobi, Adrian; Adameova, Adriana] Comenius Univ, Dept Pharmacol & Toxicol, Fac Pharm, Odbojarov 10, Bratislava 83232, Slovakia.
   [Gottlieb, Roberta A.] Cedars Sinai Med Ctr, Inst Heart, 127 S San Vicente Blvd, Los Angeles, CA 90048 USA.
   [Giricz, Zoltan; Ferdinandy, Peter] Pharmahungary Grp, Szeged, Hungary.
C3 Semmelweis University; Szeged University; Comenius University
   Bratislava; Cedars Sinai Medical Center; Pharmahungary Group
RP Giricz, Z (corresponding author), Semmelweis Univ, Dept Pharmacol & Pharmacotherapy, Fac Med, Nagyvarad Ter 4, H-1089 Budapest, Hungary.; Giricz, Z (corresponding author), Pharmahungary Grp, Szeged, Hungary.
EM giricz.zoltan@med.semmelweis-univ.hu
RI Ferdinandy, Péter/H-9181-2019; adameova, adriana/HZK-8075-2023; Giricz,
   Zoltán/B-6990-2008; Varga, Zoltan/J-9264-2017
OI Varga, Zoltan/0000-0002-2758-0784; Adameova,
   Adriana/0000-0002-9803-043X; Rajtik, Tomas/0000-0002-8320-5276
FU Hungarian Scientific Research Fund [OTKA K109737]; Ministry of
   Education, Science, Research and Sport of the Slovak Republic
   [VEGA1/0638/12]; Comenius University in Bratislava, Slovak Republic [FaF
   UK/19/2015]; Janos Bolyai Research Scholarship of the Hungarian Academy
   of Sciences; National Program of Excellence [TAMOP
   4.2.4.A/1-11-1-2012-0001, NHLBI P01 HL112730]
FX The project is financed by Hungarian Scientific Research Fund (OTKA
   K109737), Scientific Grant Agency of the Ministry of Education, Science,
   Research and Sport of the Slovak Republic (VEGA1/0638/12), Faculty of
   Pharmacy, Comenius University in Bratislava, Slovak Republic (FaF
   UK/19/2015). CC and ZG was supported by the Janos Bolyai Research
   Scholarship of the Hungarian Academy of Sciences. ZVV was supported by
   the National Program of Excellence (TAMOP 4.2.4.A/1-11-1-2012-0001).
   NHLBI P01 HL112730 to RAG.
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NR 43
TC 28
Z9 30
U1 1
U2 14
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1476-511X
J9 LIPIDS HEALTH DIS
JI Lipids Health Dis.
PD MAR 23
PY 2017
VL 16
AR 60
DI 10.1186/s12944-017-0455-0
PG 8
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA EP0RC
UT WOS:000397093400002
PM 28330474
OA gold, Green Published, Green Accepted
DA 2025-06-11
ER

PT J
AU Medic, G
   Wille, M
   Hemels, MEH
AF Medic, Goran
   Wille, Micheline
   Hemels, Michiel E. H.
TI Short- and long-term health consequences of sleep disruption
SO NATURE AND SCIENCE OF SLEEP
LA English
DT Review
DE sleep; sleep disorders; children; adolescents; adults; health status
ID SLOW-WAVE SLEEP; JOINT CONSENSUS STATEMENT; QUALITY-OF-LIFE; SHIFT WORK;
   RECOMMENDED AMOUNT; FAMILY CAREGIVERS; AMERICAN ACADEMY; CHRONIC
   INSOMNIA; YOUNG-CHILDREN; DISTURBANCE
AB Sleep plays a vital role in brain function and systemic physiology across many body systems. Problems with sleep are widely prevalent and include deficits in quantity and quality of sleep; sleep problems that impact the continuity of sleep are collectively referred to as sleep disruptions. Numerous factors contribute to sleep disruption, ranging from lifestyle and environmental factors to sleep disorders and other medical conditions. Sleep disruptions have substantial adverse short-and long-term health consequences. A literature search was conducted to provide a nonsystematic review of these health consequences (this review was designed to be nonsystematic to better focus on the topics of interest due to the myriad parameters affected by sleep). Sleep disruption is associated with increased activity of the sympathetic nervous system and hypothalamic-pituitary-adrenal axis, metabolic effects, changes in circadian rhythms, and proinflammatory responses. In otherwise healthy adults, short-term consequences of sleep disruption include increased stress responsivity, somatic pain, reduced quality of life, emotional distress and mood disorders, and cognitive, memory, and performance deficits. For adolescents, psychosocial health, school performance, and risk-taking behaviors are impacted by sleep disruption. Behavioral problems and cognitive functioning are associated with sleep disruption in children. Long-term consequences of sleep disruption in otherwise healthy individuals include hypertension, dyslipidemia, cardiovascular disease, weight-related issues, metabolic syndrome, type 2 diabetes mellitus, and colorectal cancer. All-cause mortality is also increased in men with sleep disturbances. For those with underlying medical conditions, sleep disruption may diminish the health-related quality of life of children and adolescents and may worsen the severity of common gastrointestinal disorders. As a result of the potential consequences of sleep disruption, health care professionals should be cognizant of how managing underlying medical conditions may help to optimize sleep continuity and consider prescribing interventions that minimize sleep disruption.
C1 [Medic, Goran; Wille, Micheline; Hemels, Michiel E. H.] Horizon Pharma BV, Market Access, Graadt van Roggenweg 340,Bldg D,Fifth Floor, NL-3531 AH Utrecht, Netherlands.
   [Medic, Goran] Univ Groningen, Dept Pharm, Unit Pharmacoepidemiol & Pharmacoecon, Groningen, Netherlands.
C3 University of Groningen
RP Hemels, MEH (corresponding author), Horizon Pharma BV, Market Access, Graadt van Roggenweg 340,Bldg D,Fifth Floor, NL-3531 AH Utrecht, Netherlands.
EM mhemels@horizonpharma.com
OI Medic, Goran/0000-0002-2440-8743
FU Horizon Pharma
FX Medical writing assistance for this manuscript was provided by Katie
   Gersh, PhD, of MedErgy and was funded by Horizon Pharma.
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NR 97
TC 924
Z9 1015
U1 38
U2 377
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1179-1608
J9 NAT SCI SLEEP
JI NAT. SCI. SLEEP
PY 2017
VL 9
BP 151
EP 161
DI 10.2147/NSS.S134864
PG 11
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA EV4EU
UT WOS:000401712100001
PM 28579842
OA gold, Green Published, Green Submitted
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Ren, J
   Xu, XH
   Wang, QR
   Ren, SY
   Dong, ML
   Zhang, YM
AF Ren, Jun
   Xu, Xihui
   Wang, Qiurong
   Ren, Sidney Y.
   Dong, Maolong
   Zhang, Yingmei
TI Permissive role of AMPK and autophagy in adiponectin
   deficiency-accentuated myocardial injury and inflammation in endotoxemia
SO JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
LA English
DT Article
DE Endotoxemia; Cardiac function; Adiponectin; Apoptosis; Autophagy;
   Inflammation
ID ACTIVATED PROTEIN-KINASE; CARDIAC-SPECIFIC OVEREXPRESSION; CONTRACTILE
   DYSFUNCTION ROLE; INDUCED LIVER-INJURY; LUNG INJURY; MURINE
   CARDIOMYOCYTES; HEMODYNAMIC STRESS; METABOLIC SYNDROME; HEPATIC-INJURY;
   OBESE MICE
AB Background: Adiponectin (APN), an adipose-derived adipokine, alleviates lipopolysaccharide (LPS)-induced injury in multiple organs including hearts although the underlying mechanism in endotoxemia remains elusive. This study was designed to examine the role of adiponectin in LPS-induced cardiac anomalies and inflammation as well as the underlying mechanism with a focus on autophagy a conserved machinery for bulk degradation of intracellular components.
   Methods and results: Wild-type (WT) and APN(-/-) mice were challenged with LPS (4 mg/kg) or saline for 6 h. Echocardiography, cardiomyocyte contractile and intracellular Ca2+ properties were evaluated. Markers of autophagy, apoptosis and inflammation including LOB, p62, Beclin1, AMPK, mTOR, ULK, Caspase 3, Bcl-2, Bax, TLR4, TRAF6, MyD88, IL-1B, TNF alpha, HMGB1, JNK and I kappa B were examined using Western blot or RT-PCR. Our results showed that LPS challenge reduced fractional shortening, compromised cardiomyocyte contractile capacity, intracellular Ca2+ handling properties, apoptosis and inflammation, which were accentuated by adiponectin ablation. Adiponectin ablation unmasked the LPS-induced cardiac remodeling (left ventricular end systolic diameter) and prolongation of cell shortening. The detrimental effects of adiponectin ablation were associated with dampened autophagy in response to LPS through an AMPK-mTOR-ULK1-dependent mechanism. In vivo administration of AMPK activator AICAR or the autophagy inducer rapamycin effectively attenuated or obliterated LPS-induced and adiponectin deficiency-accentuated responses without affecting TLR4, TRAF6 and MyD88.
   Conclusions: The findings suggest that AMPK and autophagy may play a permissive role in the adiponectin deficiency-exacerbated cardiac dysfunction, apoptosis and inflammation under LPS challenge possibly at the post-TLR4 receptor level. (C) 2016 Elsevier Ltd. All rights reserved.
C1 [Ren, Jun; Zhang, Yingmei] Fudan Univ, Shanghai Inst Cardiovasc Dis, Zhongshan Hosp, Shanghai 200032, Peoples R China.
   [Ren, Jun; Xu, Xihui; Wang, Qiurong; Ren, Sidney Y.; Dong, Maolong; Zhang, Yingmei] Univ Wyoming, Ctr Cardiovasc Res & Alternat Med, Coll Hlth Sci, Laramie, WY 82071 USA.
   [Dong, Maolong] Fourth Mil Med Univ, Xijing Hosp, Dept Burn & Cutaneous Surg, Xian 710032, Peoples R China.
C3 Fudan University; University of Wyoming; Air Force Medical University
RP Ren, J; Zhang, YM (corresponding author), Fudan Univ, Shanghai Inst Cardiovasc Dis, Zhongshan Hosp, Shanghai 200032, Peoples R China.
EM renjun@zs-hospital.sh.cn; zhangym197951@126.com
RI Xu, Xihui/C-2017-2014; Ren, Jun/ACG-5366-2022
OI Wang, Qiurong/0000-0001-9654-9126; Ren, Jun/0000-0002-0275-0783
FU NIH/NIGMS [8P20GM103432]; National Natural Science Foundation of China
   [NSFC81570225]
FX This work was supported in part by NIH/NIGMS 8P20GM103432 and the
   National Natural Science Foundation of China (NSFC81570225) to JR.
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NR 66
TC 49
Z9 52
U1 0
U2 21
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0022-2828
EI 1095-8584
J9 J MOL CELL CARDIOL
JI J. Mol. Cell. Cardiol.
PD APR
PY 2016
VL 93
BP 18
EP 31
DI 10.1016/j.yjmcc.2016.02.002
PG 14
WC Cardiac & Cardiovascular Systems; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Cell Biology
GA DM1ZL
UT WOS:000376145300003
PM 26906634
DA 2025-06-11
ER

PT J
AU Abd El-Haleim, EA
   Bahgat, AK
   Saleh, S
AF Abd El-Haleim, Enas A.
   Bahgat, Ashraf K.
   Saleh, Samira
TI Effects of combined PPAR-γ and PPAR-α agonist therapy on fructose
   induced NASH in rats: Modulation of gene expression
SO EUROPEAN JOURNAL OF PHARMACOLOGY
LA English
DT Article
DE PPAR; NASH; SOCS-3; SREBP-1c; Leptin; Adiponectin
ID NONALCOHOLIC FATTY LIVER; NECROSIS-FACTOR-ALPHA; INSULIN-RESISTANCE;
   RECEPTOR-ALPHA; ADIPOSE-TISSUE; METABOLIC SYNDROME; FENOFIBRATE
   TREATMENT; OBESE MICE; KAPPA-B; STEATOHEPATITIS
AB Peroxisome proliferator-activated receptors (PPARs) gamma and alpha have been shown to play key roles in maintaining glucose and lipid homeostasis by acting as insulin sensitizers and lipid-lowering agents respectively, which would make them potential candidates for the treatment of non-alcoholic steatohepatitis (NASH) characterized by insulin resistance, hyperglycemia, and hypertriglyceridemia. The effects of pioglitazone, a PPAR-gamma agonist, and fenofibrate, a PPAR-alpha agonist, as monotherapy and in combination on the expressions of key genes linked to the development of NASH were studied in rats with fructose-induced NASH. Fructose-enriched diet was given to rats for 12 weeks. Fenofibrate (100 mg/kg), pioglitazone (4 mg/kg) and combined treatment with both in half doses were given. Body weight, liver index, insulin resistance indices, triglycerides, oxidative stress markers, AST/ALT ratio and TNF-alpha were measured. Additionally, hepatic genes expressions of SOCS-3, sterol regulatory element binding protein-1c, fatty acid synthase, malonyl CoA decarboxylase, TGF-beta 1, and adipose tissue genes expressions of leptin and adiponectin were investigated. The combination of both drugs, in half doses, improved NASH-related disturbances similar to, or even better than, a full dose of fenofibrate alone possibly due to attenuating effects of pioglitazone on expression of genes responsible for insulin resistance, fatty acid synthesis and fibrosis in addition to correcting the balance between leptin and adiponectin. Histopathology confirmed the ability of this combination to decrease steatosis area and to normalize hepatic tissue structure. In Conclusion, dual activation of PPAR-gamma and PPAR-alpha has remarkable effect in ameliorating NASH by modulation of some hepatic and adipose tissue genes expressions. (C) 2016 Elsevier B.V. All rights reserved.
C1 [Abd El-Haleim, Enas A.; Bahgat, Ashraf K.; Saleh, Samira] Cairo Univ, Fac Pharm, Dept Pharmacol & Toxicol, Cairo, Egypt.
C3 Egyptian Knowledge Bank (EKB); Cairo University
RP Abd El-Haleim, EA (corresponding author), Cairo Univ, Fac Pharm, Dept Pharmacol & Toxicol, Cairo, Egypt.
EM enas.ahmed@pharma.cu.edu.eg
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NR 68
TC 27
Z9 32
U1 0
U2 14
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0014-2999
EI 1879-0712
J9 EUR J PHARMACOL
JI Eur. J. Pharmacol.
PD FEB 15
PY 2016
VL 773
BP 59
EP 70
DI 10.1016/j.ejphar.2016.01.011
PG 12
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA DC8XZ
UT WOS:000369504900007
PM 26825546
DA 2025-06-11
ER

PT J
AU Zheng, JJ
   Wu, YH
   Li, ZR
   Wang, HN
   Xiao, WH
   Shi, YY
   Wang, TC
AF Zheng, Jiajia
   Wu, Yonghua
   Li, Zhenrong
   Wang, Haining
   Xiao, Wenhua
   Shi, Yanyan
   Wang, Tiancheng
TI Low Serum Total Bilirubin Concentration was Associated with Increased
   High Sensitive C Reactive Protein Level in Patients with Impaired
   Glucose Tolerance and Type 2 Diabetes Mellitus Subjects
SO CLINICAL LABORATORY
LA English
DT Article
ID ACUTE MYOCARDIAL-INFARCTION; CORONARY-ARTERY-DISEASE; METABOLIC
   SYNDROME; OXIDATIVE STRESS; HEME OXYGENASE-1; KOREAN ADULTS; COUNTS;
   RISK
AB Background: Serum total bilirubin (TB) has been recognized as a potent endogenous antioxidant under physiological conditions, and serum high sensitive C reactive protein (hs-CRP) is the most commonly used marker which reflects activation of systemic inflammation in the body. The study investigated the association between these two indicators and further evaluated the anti-inflammatory effects of bilirubin and its clinical significance in impaired glucose tolerance (IGT) and type 2 diabetes mellitus (T2DM) individuals.
   Methods: A group of 94 patients with T2DM, 68 persons with IGT, and 62 age and gender matched healthy control subjects were recruited. The serum TB, hs-CRP concentrations, carotid artery intima-media thickness (C-IMT), and other biochemical indicators were measured. The association between serum TB, hs-CRP concentrations, and C-IMT were investigated using Spearman's correlation test. The influence of analyzed parameters including the age, gender, serum TB, and hs-CRP, etc. in IGT and T2DM was assessed by binary logistic regression analyses.
   Results: The serum TB level decreased significantly in patients of IGT and T2DM (p < 0.01) and serum hs-CRP concentrations were significantly increased in IGT and T2DM (p < 0.01) compared with healthy controls. Meanwhile, the serum TB levels was negatively correlated with serum hs-CRP (P < 0.05) and C-IMT (P < 0.05) in IGT and T2DM. Logistic regression analysis showed that the serum TB was a protective factor (OR = 0.852, P = 0.045) and serum hs-CRP was a risk factor (OR = 2.010, P = 0.006) for IGT and T2DM.
   Conclusions: Lower serum TB is associated with enhancement of the inflammatory response in IGT and T2DM. The serum TB may play a crucial role in inflammatory by contributing to inhibit the inflammation effect.
C1 [Zheng, Jiajia; Wu, Yonghua; Li, Zhenrong; Wang, Tiancheng] Peking Univ, Hosp 3, Dept Lab Med, Beijing 100871, Peoples R China.
   [Wang, Haining; Xiao, Wenhua] Peking Univ, Hosp 3, Dept Endocrinol, Beijing 100871, Peoples R China.
   [Shi, Yanyan] Peking Univ, Hosp 3, Clin Epidemiol Res Ctr, Beijing 100871, Peoples R China.
C3 Peking University; Peking University; Peking University
RP Wang, TC (corresponding author), 49 North Huayuan Rd, Beijing 100191, Peoples R China.
EM tcwang@bjmu.edu.cn
FU National Natural Science Foundation of China [81400607]
FX National Natural Science Foundation of China 81400607.
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NR 28
TC 9
Z9 9
U1 0
U2 14
PU CLIN LAB PUBL
PI HEIDELBERG
PA IM BREITSPIEL 15, HEIDELBERG, D-69126, GERMANY
SN 1433-6510
J9 CLIN LAB
JI Clin. Lab.
PY 2016
VL 62
IS 5
BP 901
EP 907
DI 10.7754/Clin.Lab.2015.150936
PG 7
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA DL9MV
UT WOS:000375968300020
PM 27349017
DA 2025-06-11
ER

PT J
AU Ferreira, DF
   Fiamoncini, J
   Prist, IH
   Ariga, SK
   de Souza, HP
   de Lima, TM
AF Ferreira, Darkiane Fernandes
   Fiamoncini, Jarlei
   Prist, Iryna Hirata
   Ariga, Suely Kubo
   de Souza, Heraldo Possolo
   de Lima, Thais Martins
TI Novel role of TLR4 in NAFLD development: Modulation of metabolic enzymes
   expression
SO BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
LA English
DT Article
DE Toll like receptor 4; Non-alcoholic fatty liver disease; Fatty acid
   oxidation; LDL receptor knockout; High-fat diet; Acyl-carnitine profile
ID FATTY LIVER-DISEASE; TOLL-LIKE RECEPTOR-4; NONALCOHOLIC STEATOHEPATITIS;
   INSULIN-RESISTANCE; DEFICIENT MICE; HEPATIC STEATOSIS; OXIDATIVE STRESS;
   BETA-OXIDATION; MOUSE MODELS; INFLAMMATION
AB The rise in the prevalence of obesity and metabolic syndrome turned NAFLD as the most common cause of chronic liver diseases worldwide. Although the role of toll like receptors, especially TLR4, as activators of inflammatory pathways in liver diseases is well established, our goal was to investigate if TLR4 activation could modulate metabolic lipid pathways and alter the onset of NAFLD. We used LDL receptor-deficient mice (LDLrKO) fed with an atherogenic diet as a model. The role of TLR4 activation was evaluated by crossing LDLrKO mice with the TLR4 knockout mice. Animals were fed for 12 weeks with high-fat high-cholesterol diet (HFD) containing 18% saturated fat and 1.25% cholesterol. TLR4/LDLr KO mice presented lower triacylglyceride (TAG) plasma levels when compared to LDLrKO, despite the type of diet ingested. HFD induced TAG and cholesterol accumulation in the liver of all mice genotypes studied, but TLR4/LDLr KO presented lower TAG accumulation than LDLrKO mice. Gene expression of TAG synthesis enzymes (ApoB100, MTTP, GPAT1 and GPAT4) was not differentially altered in TLR4/LDLr KO and LDLrKO mice. On the other hand, TLR4 deficiency enhanced the expression of several enzymes involved in the oxidation of fatty acids, as follows: ACOX, CPT-1, MTPa, MTBb, PBE and 3-ketoacyl-CoA thiolase. Acyl-camitine plasma profile showed an increase in C0 and C2 concentration in TLR4/LDLr KO group, corroborating the hypothesis of increased fat oxidation. Our results indicate that TLR4 may have an important role in the onset of steatosis, once its depletion enhances fatty acid oxidation in the liver of mice, preventing triglyceride accumulation. (C) 2015 Elsevier B.V. All rights reserved.
C1 [Ferreira, Darkiane Fernandes; Prist, Iryna Hirata; Ariga, Suely Kubo; de Souza, Heraldo Possolo; de Lima, Thais Martins] Univ Sao Paulo, Sch Med, Dept Emergency Med, Sao Paulo, Brazil.
   [Fiamoncini, Jarlei] Tech Univ Munich, Biochem Unit, ZIEL Res Ctr Nutr & Food Sci, Freising Weihenstephan, Germany.
C3 Universidade de Sao Paulo; Technical University of Munich
RP de Lima, TM (corresponding author), Univ Sao Paulo, Fac Med, LIM 51, Av Dr Arnaldo 455,3 Andar,Sala 3189, BR-01246903 Sao Paulo, SP, Brazil.
EM thais@emercli.fm.usp.br
RI SOUZA, HERALDO/AAX-7878-2021; Lima, Thais/C-2767-2012; Fiamoncini,
   Jarlei/L-5497-2017
OI SOUZA, HERALDO/0000-0003-2499-5674; Lima, Thais/0000-0003-3175-5281;
   Fiamoncini, Jarlei/0000-0002-8456-983X
FU FAPESP [09/01990-9, 09/07946-1]; Fundacao de Amparo a Pesquisa do Estado
   de Sao Paulo (FAPESP) [09/07946-1, 09/01990-9] Funding Source: FAPESP
FX The authors are grateful to the technical assistance of Geraldo Gomes
   Sobrinho, Fatima Abatepaulo and Kelli Cristina Theodoro Gouvea. This
   study was supported by the FAPESP - 09/01990-9 and 09/07946-1.
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NR 36
TC 33
Z9 39
U1 0
U2 28
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1388-1981
EI 0006-3002
J9 BBA-MOL CELL BIOL L
JI Biochim. Biophys. Acta Mol. Cell Biol. Lipids
PD OCT
PY 2015
VL 1851
IS 10
BP 1353
EP 1359
DI 10.1016/j.bbalip.2015.07.002
PG 7
WC Biochemistry & Molecular Biology; Biophysics; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Cell Biology
GA CR5SA
UT WOS:000361403100008
PM 26172853
DA 2025-06-11
ER

PT J
AU Keller, A
   Rohde, JF
   Raymond, K
   Heitmann, BL
AF Keller, Amelie
   Rohde, Jeanett F.
   Raymond, Kyle
   Heitmann, Berit L.
TI Association Between Periodontal Disease and Overweight and Obesity: A
   Systematic Review
SO JOURNAL OF PERIODONTOLOGY
LA English
DT Review
DE Adiposity; body mass index; inflammation; obesity; oral health;
   periodontitis
ID BODY-MASS INDEX; METABOLIC SYNDROME; OXIDATIVE STRESS; ORAL-DISEASES;
   WEIGHT; INFLAMMATION; PREDICT; YOUNG; PROGRESSION; ADIPOSITY
AB Background: Periodontitis and obesity are among the most common chronic disorders affecting the world's populations, and recent reviews suggest a potential link between overweight/obesity and periodontitis. However, because of the scarcity of prospective evidence, previous reviews were primarily based on cross-sectional studies, with only a few longitudinal or intervention studies included. This study's objective is to examine the time-dependent association between obesity and periodontitis and how weight changes may affect the development of periodontitis in the general population. Therefore, longitudinal and experimental studies that assessed the association among overweight, obesity, weight gain, waist circumference, and periodontitis are reviewed.
   Methods: Intervention and longitudinal studies with overweight or obesity as exposure and periodontitis as outcome were searched through the platforms PubMed/Medline and Web of Knowledge.
   Results: Eight longitudinal and five intervention studies were included. Two of the longitudinal studies found a direct association between degree of overweight at baseline and subsequent risk of developing periodontitis, and a further three studies found a direct association between obesity and development of periodontitis among adults. Two intervention studies on the influence of obesity on periodontal treatment effects found that the response to non-surgical periodontal treatment was better among lean than obese patients; the remaining three studies did not report treatment differences between obese and lean participants. Among the eight longitudinal studies, one study adjusted for C-reactive protein (CRP) and biologic markers of inflammation such as CRP, interleukin-6, and tumor necrosis factor-a, and inflammation markers were analyzed separately in three of the five intervention studies.
   Conclusion: This systematic review suggests that overweight, obesity, weight gain, and increased waist circumference may be risk factors for development of periodontitis or worsening of periodontal measures.
C1 [Keller, Amelie; Rohde, Jeanett F.; Raymond, Kyle; Heitmann, Berit L.] Bispebjerg & Frederiksberg Hosp, Inst Prevent Med, DK-2000 Copenhagen, Denmark.
   [Keller, Amelie; Rohde, Jeanett F.; Raymond, Kyle; Heitmann, Berit L.] Bispebjerg Hosp, Res Unit Dietary Studies, Parker Inst, Copenhagen, Denmark.
   [Keller, Amelie; Rohde, Jeanett F.; Raymond, Kyle; Heitmann, Berit L.] Frederiksberg Univ Hosp, Res Unit Dietary Studies, Parker Inst, Frederiksberg, Denmark.
   [Rohde, Jeanett F.; Heitmann, Berit L.] Univ Southern Denmark, Inst Publ Hlth, Copenhagen, Denmark.
   [Heitmann, Berit L.] Univ Sydney, Boden Inst Obes Nutr Exercise & Eating Disorders, Sydney, NSW 2006, Australia.
C3 University of Copenhagen; Bispebjerg Hospital; University of Copenhagen;
   Copenhagen University Hospital; Bispebjerg Hospital; University of
   Southern Denmark; University of Sydney
RP Keller, A (corresponding author), Bispebjerg & Frederiksberg Hosp, Inst Prevent Med, Nordre Fasanvej 57, DK-2000 Copenhagen, Denmark.
EM amelie.cleo.keller@regionh.dk
RI Heitmann, Berit/JBJ-6043-2023; keller, amelie/M-4029-2013
OI Rohde, Jeanett Friis/0000-0002-9300-9009; Heitmann, Berit
   Lilienthal/0000-0002-6809-4504; Keller, Amelie/0000-0003-1404-6715
FU Tryg foundation, Virum, Denmark
FX All studies but one had a statement regarding conflict of interest. All
   studies were publicly funded, and one study further reported partial
   private funding<SUP>50</SUP> (see supplementary Table 5 in online
   Journal of Periodontology). This review was supported by Tryg
   foundation, Virum, Denmark. The authors report no conflicts of interest
   related to this study.
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NR 63
TC 173
Z9 195
U1 0
U2 35
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-3492
EI 1943-3670
J9 J PERIODONTOL
JI J. Periodont.
PD JUN
PY 2015
VL 86
IS 6
BP 766
EP 776
DI 10.1902/jop.2015.140589
PG 11
WC Dentistry, Oral Surgery & Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dentistry, Oral Surgery & Medicine
GA CJ1SX
UT WOS:000355265900005
PM 25672656
DA 2025-06-11
ER

PT J
AU Ragab, SM
   Safan, MA
   Obeid, OM
   Sherief, AS
AF Ragab, Seham M.
   Safan, Manal A.
   Obeid, Osama M.
   Sherief, Asmaa S.
TI Lipoprotein-associated phospholipase A2 (Lp-PLA2) and tumor necrosis
   factor-alpha (TNF-α) and their relation to premature atherosclerosis in
   β-thalassemia children
SO HEMATOLOGY
LA English
DT Article
DE beta-Thalassemia; Carotid intima-media thickness (cIMT); Lp-PLA2;
   TNF-alpha; Premature atherosclerosis
ID INTIMA-MEDIA THICKNESS; ACTIVATING FACTOR-ACETYLHYDROLASE; SUBCLINICAL
   ATHEROSCLEROSIS; METABOLIC SYNDROME; ENDOTHELIAL-CELLS; OXIDATIVE
   STRESS; IRON OVERLOAD; HEART-DISEASE; NITRIC-OXIDE; HEPATITIS-C
AB Background/Objectives: Beta (beta)-thalassemia adults are prone to premature atherosclerosis but data about this complication among thalassemia children are few. Lipoprotein-associated phospholipase A2 (Lp-PLA2) and tumor necrosis factor-alpha (TNF-alpha) are inflammatory markers that could be implicated in atherosclerotic process. We investigated Lp-PLA2 and TNF-alpha levels in beta-thalassemia children and their relation to subclinical atherosclerosis.
   Methods: Twenty-two beta-thalassemia major (TM), 20 beta-thalassemia intermedia children, and 30 age- and sex-matched healthy controls were included. Lipid profile (by colorimetric assay), serum ferritin, TNF-alpha, and plasma Lp-PLA2 levels (by enzyme-linked immunosorbent assay technique) were estimated. Carotid intima-media thickness (cIMT) was measured by high-resolution ultrasound.
   Results: Both patient groups exhibited anti-atherogenic lipid profile except increased serum triglycerides. They had significantly higher plasma Lp-PLA2 and serum TNF-alpha compared to the controls (P < 0.001). Elevated cIMT was documented in 57% of the thalassemia children and was higher among hepatitis C (HCV) positive patients. Serum ferritin, TNF-alpha, and plasma Lp-PLA2 levels were significantly higher in patients with premature atherosclerosis. cIMT correlated significantly with serum ferritin, TNF-alpha, and plasma Lp-PLA2 in both patient groups. Among TM children, serum ferritin had significant positive correlation with serum TNF-alpha and plasma Lp-PLA2. The elevation of both markers was not related to HCV infection.
   Conclusions: Premature atherosclerosis is common among young thalassemia children. Lp-PLA2 and TNF-alpha are significantly increased in thalassemia children and show strong correlations with cIMT, suggesting that both of them may be appreciated as modulating factors in carotid atherosclerosis pathophysiological process among these children.
C1 [Ragab, Seham M.] Menoufia Univ, Fac Med, Dept Pediat, Menoufia, Egypt.
   [Safan, Manal A.] Menoufia Univ, Fac Med, Dept Med Biochem, Menoufia, Egypt.
   [Obeid, Osama M.] Menoufia Univ, Fac Med, Dept Radiol, Menoufia, Egypt.
   [Sherief, Asmaa S.] Shebeen El Kom Teaching Hosp, Menoufia, Egypt.
C3 Egyptian Knowledge Bank (EKB); Menofia University; Egyptian Knowledge
   Bank (EKB); Menofia University; Egyptian Knowledge Bank (EKB); Menofia
   University
RP Ragab, SM (corresponding author), Menoufia Univ, Fac Med, Dept Pediat, Hematol & Oncol Unit, Menouf 7th,EL Hadetha St, Minoufia 32511, Egypt.
EM sehambasel@Gmail.com
RI Ragab, Seham/AAW-2022-2020
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NR 68
TC 32
Z9 34
U1 0
U2 10
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1024-5332
EI 1607-8454
J9 HEMATOLOGY
JI Hematology
PD MAY
PY 2015
VL 20
IS 4
BP 228
EP 238
DI 10.1179/1607845414Y.0000000180
PG 11
WC Hematology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Hematology
GA CG6OV
UT WOS:000353422400008
PM 25056687
OA Bronze
DA 2025-06-11
ER

PT J
AU Nguyen, PL
   Jarolim, P
   Basaria, S
   Zuflacht, JP
   Milian, J
   Kadivar, S
   Graham, PL
   Hyatt, A
   Kantoff, PW
   Beckman, JA
AF Nguyen, Paul L.
   Jarolim, Petr
   Basaria, Shehzad
   Zuflacht, Jonah P.
   Milian, Jessica
   Kadivar, Samoneh
   Graham, Powell L.
   Hyatt, Andrew
   Kantoff, Philip W.
   Beckman, Joshua A.
TI Androgen Deprivation Therapy Reversibly Increases Endothelium-Dependent
   Vasodilation in Men With Prostate Cancer
SO JOURNAL OF THE AMERICAN HEART ASSOCIATION
LA English
DT Article
DE androgen deprivation therapy; endothelial function; inflammation;
   insulin resistance; prostate cancer
ID FLOW-MEDIATED DILATION; CARDIOVASCULAR-DISEASE; INSULIN-RESISTANCE;
   BRACHIAL-ARTERY; MYOCARDIAL-INFARCTION; VASCULAR REACTIVITY; SERUM
   TESTOSTERONE; METABOLIC SYNDROME; OXIDATIVE STRESS; RISK
AB Background-Androgen deprivation therapy (ADT) is a standard treatment for patients with aggressive prostate cancer. Although ADT improves survival, it increases the risk of diabetes. Emerging evidence suggests that ADT increases adverse cardiovascular events as early as 3 months after initiation in patients with cardiovascular disease, but the mechanism is unknown. We hypothesized that ADT may impair endothelium-dependent vasodilation due to increases in lipids and insulin resistance and may provide a link for heightened cardiovascular risk in this population.
   Methods and Results-We prospectively evaluated conduit artery endothelium-dependent and -independent vasodilation, lipids, and insulin resistance in 16 consecutively treated men (mean age 66 +/- 7 years; 25% with diabetes) with prostate cancer before and after 3 months of ADT. High-resolution B-mode ultrasound was used to assess flow-mediated (endothelium-dependent) and nitroglycerine-mediated (endothelium-independent) brachial artery vasodilation. ADT significantly increased insulin resistance, total cholesterol, HDL, and LDL. Endothelium-dependent vasodilation was greater at 3 months than at baseline (10.8% [interquartile range: 7.7% to 14.6%] versus 8.9% [interquartile range: 4.0% to 12.6%], respectively; P=0.046, allometric P=0.037). Nitroglycerine-mediated vasodilation did not change from baseline (P>0.2). The subset of participants on ADT for 6 months returned for reevaluation at 1 year. In this group, endothelium-dependent vasodilation increased from baseline to 3 months and returned to baseline 6 months after ADT withdrawal (9.4% [interquartile range: 6.9% to 10.9%], 11.6% [interquartile range: 7.9% to 15.2%], and 9.0% [interquartile range: 5.1% to 12.5%], respectively; P=0.05).
   Conclusions-In contrast to our expectation, ADT improved endothelium-dependent vasodilation and its cessation returned endothelium-dependent vasodilation to baseline. Determining the mechanism of this change requires further investigation.
C1 [Nguyen, Paul L.; Graham, Powell L.; Hyatt, Andrew] Brigham & Womens Hosp, Radiat Oncol, Boston, MA 02115 USA.
   [Nguyen, Paul L.; Graham, Powell L.; Hyatt, Andrew] Dana Farber Canc Inst, Boston, MA 02115 USA.
   [Zuflacht, Jonah P.; Milian, Jessica; Kadivar, Samoneh; Beckman, Joshua A.] Brigham & Womens Hosp, Div Cardiovasc, Boston, MA 02115 USA.
   [Jarolim, Petr] Brigham & Womens Hosp, Dept Pathol, Boston, MA 02115 USA.
   [Basaria, Shehzad] Brigham & Womens Hosp, Dept Endocrinol, Boston, MA 02115 USA.
   [Kantoff, Philip W.] Dana Farber Canc Inst, Med Oncol, Boston, MA 02115 USA.
C3 Harvard University; Harvard University Medical Affiliates; Brigham &
   Women's Hospital; Harvard University; Harvard University Medical
   Affiliates; Dana-Farber Cancer Institute; Harvard University; Harvard
   University Medical Affiliates; Brigham & Women's Hospital; Harvard
   University; Harvard University Medical Affiliates; Brigham & Women's
   Hospital; Harvard University; Harvard University Medical Affiliates;
   Brigham & Women's Hospital; Harvard University; Harvard University
   Medical Affiliates; Dana-Farber Cancer Institute
RP Beckman, JA (corresponding author), 75 Francis St, Boston, MA 02115 USA.
EM jbeckman@partners.org
RI ; Beckman, Joshua/A-7537-2016
OI Nguyen, Paul/0000-0003-4268-3973; Beckman, Joshua/0000-0001-8332-8439;
   Kantoff, Philip/0000-0001-7275-0597; Keilson,
   Jessica/0000-0002-8695-431X
FU Watkins Discovery Award; Prostate Cancer Foundation; Fitz's Cancer
   Warriors; David and Cynthia Chapin
FX This study was supported by Watkins Discovery Award, the Prostate Cancer
   Foundation, Fitz's Cancer Warriors, David and Cynthia Chapin, and a
   grant from an Anonymous Family Foundation.
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NR 50
TC 19
Z9 19
U1 0
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2047-9980
J9 J AM HEART ASSOC
JI J. Am. Heart Assoc.
PD APR
PY 2015
VL 4
IS 4
AR e001914
DI 10.1161/JAHA.115.001914
PG 8
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA CH6HN
UT WOS:000354137300033
PM 25896892
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Oh, SW
   Baek, SH
   Kim, YC
   Goo, HS
   Chin, HJ
   Na, KY
   Chae, DW
   Kim, S
AF Oh, Se Won
   Baek, Seon Ha
   Kim, Yong Chul
   Goo, Ho Suk
   Chin, Ho Jun
   Na, Ki Young
   Chae, Dong Wan
   Kim, Suhnggwon
TI Higher hemoglobin level is associated with subtle declines in renal
   function and presence of cardiorenal risk factors in early CKD stages
SO NEPHROLOGY DIALYSIS TRANSPLANTATION
LA English
DT Article
DE cardio renal risk factor; glomerular filtration rate; hemoglobin; renal
   response
ID CHRONIC KIDNEY-DISEASE; CARDIOVASCULAR-DISEASE; INSULIN-RESISTANCE;
   METABOLIC SYNDROME; ATHEROSCLEROSIS; ERYTHROPOIETIN; PREVALENCE;
   MECHANISMS; HYPOXIA; STRESS
AB Background. Patients with advanced renal dysfunction have comorbidities, including anemia, as a consequence of reduced production of erythropoietin. However, little is known about the renal response to early decreases in estimated glomerular filtration rate (eGFR) before the onset of anemia. We therefore investigated the hemoglobin concentration across subtle declines in renal function stratified by cardiorenal risk factors, in subjects with eGFR >= 50 mL/min/1.73 m(2).
   Methods. Based on the data from routine health checkups in tertiary university hospitals during the last 15 years, 145 865 adult subjects were identified.
   Results. Hemoglobin levels among eGFR Groups 2-6 (50 <= eGFR < 100 mL/min/1.73m(2)) were significantly higher compared to eGFR group >= 100 mL/min/1.73m(2) (P < 0.001), and the highest level of mean hemoglobin was seen at eGFR 50-59 mL/min/1.73m(2). The mean hemoglobin level of subjects with eGFR 50-59 mL/min/1.73m(2) and eGFR >= 100 mL/min/1.73m(2) were 13.36 [95% confidence interval (CI): 13.33-13.40] g/dL versus 12.92 (95% CI: 12.88-12.95) g/dL in women (P < 0.001); in men, 15.60 (95% CI: 15.57-15.63) g/dL versus 15.15 (95% CI: 15.11-15.18) g/dL (P < 0.001). Among each eGFR group, hemoglobin levels were higher in subjects with hypertension (P < 0.001 in both genders), diabetes mellitus (P < 0.001 in both genders) and components of MS (P < 0.003 in both genders) compared to subjects without these conditions.
   Conclusion. Hemoglobin concentration may be slightly higher across subtle declines in renal function and the presence of cardiorenal risk factors in early CKD stages.
C1 [Oh, Se Won; Chin, Ho Jun; Na, Ki Young; Chae, Dong Wan] Seoul Natl Univ, Dept Internal Med, Bundang Hosp, Kyeong Kido, South Korea.
   [Baek, Seon Ha; Kim, Yong Chul; Goo, Ho Suk; Na, Ki Young; Chae, Dong Wan; Kim, Suhnggwon] Seoul Natl Univ, Coll Med, Dept Internal Med, Seoul 151, South Korea.
   [Chin, Ho Jun; Kim, Suhnggwon] Seoul Natl Univ, Renal Inst, Med Res Ctr, Seoul 151, South Korea.
C3 Seoul National University (SNU); Seoul National University (SNU); Seoul
   National University (SNU)
RP Chin, HJ (corresponding author), Seoul Natl Univ, Dept Internal Med, Bundang Hosp, Kyeong Kido, South Korea.
EM mednep@snubh.org
RI Kim, Suhnggwon/J-5407-2012; Chae, Dong-Wan/J-5681-2012; Chin,
   Ho/J-5678-2012; Kim, Yong/L-8653-2019; Na, Ki/J-5456-2012; Oh, Se
   Won/G-2632-2017
OI Kim, Yong Chul/0000-0003-3215-8681; Oh, Se Won/0000-0003-3795-9322
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NR 41
TC 10
Z9 11
U1 0
U2 4
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0931-0509
EI 1460-2385
J9 NEPHROL DIAL TRANSPL
JI Nephrol. Dial. Transplant.
PD JAN
PY 2012
VL 27
IS 1
BP 267
EP 275
DI 10.1093/ndt/gfr296
PG 9
WC Transplantation; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Transplantation; Urology & Nephrology
GA 887UY
UT WOS:000299957700042
PM 21669882
OA Bronze
DA 2025-06-11
ER

PT J
AU Gauthier, MS
   O'Brien, EL
   Bigornia, S
   Mott, M
   Cacicedo, JM
   Xu, XJ
   Gokce, N
   Apovian, C
   Ruderman, N
AF Gauthier, Marie-Soleil
   O'Brien, Elena L.
   Bigornia, Sherman
   Mott, Melanie
   Cacicedo, Jose M.
   Xu, X. Julia
   Gokce, Noyan
   Apovian, Caroline
   Ruderman, Neil
TI Decreased AMP-activated protein kinase activity is associated with
   increased inflammation in visceral adipose tissue and with whole-body
   insulin resistance in morbidly obese humans
SO BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
LA English
DT Article
DE AMP-activated protein kinase; Adipose tissue; Humans; Insulin sensitive
   obese; Inflammation; Insulin resistance
ID VEIN ENDOTHELIAL-CELLS; METABOLIC SYNDROME; OXIDATIVE STRESS;
   SKELETAL-MUSCLE; MALONYL-COA; ADIPOCYTES; LIPOLYSIS; INHIBITION;
   ACCUMULATION; INFILTRATION
AB Inflammation and infiltration of immune cells in white adipose tissue have been implicated in the development of obesity-associated insulin resistance. Likewise, dysregulation of the fuel-sensing enzyme AMP-activated protein kinase (AMPK) has been proposed as a pathogenetic factor for these abnormalities based on both its links to insulin action and its anti-inflammatory effects. In this study, we examined the relationships between AMPK activity, the expression of multiple inflammatory markers in visceral (mesenteric and omental) and abdominal subcutaneous adipose tissue, and whole-body insulin sensitivity in morbidly obese patients (BMI 48 +/- 1.9 kg/m(2)) undergoing gastric bypass surgery. AMPK activity was assessed by Western-blots (P-AMPK/T-AMPK) and mRNA levels of various markers of inflammation by qRT-PCR. Patients were stratified as insulin sensitive obese or insulin-resistant obese according to their HOMA-IR values. The results indicate that AMPK activity is lower in visceral than in subcutaneous abdominal adipose tissue of these patients and that this is associated with an increased expression of multiple inflammatory genes. They also revealed that AMPK activity is lower in adipose tissue of obese patients who are insulin resistant (HOMA-IR > 2.3) than in BMI-matched insulin sensitive subjects. Furthermore, this difference was evident in all three fat depots. In conclusion, the data suggest that there are close links between reduced AMPK activity and inflammation in white adipose tissue, and whole-body insulin resistance in obese humans. Whether adipose tissue AMPK dysregulation is a causal factor for the development of the inflammation and insulin resistance remains to be determined. (C) 2010 Elsevier Inc. All rights reserved.
C1 [Gauthier, Marie-Soleil; O'Brien, Elena L.; Bigornia, Sherman; Cacicedo, Jose M.; Xu, X. Julia; Apovian, Caroline; Ruderman, Neil] Boston Univ, Sch Med, Diabet & Metab Unit, Endocrinol Sect, Boston, MA 02118 USA.
   [Mott, Melanie; Gokce, Noyan] Boston Univ, Sch Med, Whitaker Cardiovasc Inst, Boston, MA 02118 USA.
C3 Boston University; Boston University
RP Gauthier, MS (corresponding author), Montreal Diabet Res Ctr CR CHUM, Montreal, PQ, Canada.
EM ms.gauthier@gmail.com; nrude@bu.edu
OI Apovian, Caroline/0000-0002-8029-1922; Gokce, Noyan/0000-0003-2920-3445;
   Ruderman, Neil/0000-0002-6589-6587; /0000-0001-8417-9754; Xu,
   Julia/0000-0002-2564-8052
FU USPHS [RO1 DK19514, RO1 DK067509, PO1-HL68758]; American Diabetes
   Association; USDA [58-1950-7-707]; Robert C. and Veronica Atkins
   Foundation; Fonds de la Recherche en Sante du Quebec
FX Parts of this work were presented at the Obesity Society Meeting in
   Washington DC in October 2009 and published as an abtract [42]. The
   authors thank Kathleen Tumelty for technical assistance, and Sharon
   Mosher and Anupriya Mundra for their assistance in preparing the
   manuscript. This study was supported in part by USPHS grants, RO1
   DK19514 and DK067509, PO1-HL68758 and a Mentor-based Fellowship Award
   from the American Diabetes Association (NR). It was also supported by
   USDA Contract 58-1950-7-707 and a grant from the Robert C. and Veronica
   Atkins Foundation (C.M.A). Marie-Soleil Gauthier was supported by a
   postdoctoral research fellowship from Fonds de la Recherche en Sante du
   Quebec and is a Canadian Diabetes Association fellow.
CR Abbasi F, 2004, DIABETES, V53, P585, DOI 10.2337/diabetes.53.3.585
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NR 42
TC 178
Z9 189
U1 0
U2 18
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0006-291X
EI 1090-2104
J9 BIOCHEM BIOPH RES CO
JI Biochem. Biophys. Res. Commun.
PD JAN 7
PY 2011
VL 404
IS 1
BP 382
EP 387
DI 10.1016/j.bbrc.2010.11.127
PG 6
WC Biochemistry & Molecular Biology; Biophysics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics
GA 710CE
UT WOS:000286487700068
PM 21130749
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Gupte, S
   Labinskyy, N
   Gupte, R
   Csiszar, A
   Ungvari, Z
   Edwards, JG
AF Gupte, Sachin
   Labinskyy, Nazar
   Gupte, Rakhee
   Csiszar, Anna
   Ungvari, Zoltan
   Edwards, John G.
TI Role of NAD(P)H Oxidase in Superoxide Generation and Endothelial
   Dysfunction in Goto-Kakizaki (GK) Rats as a Model of Nonobese NIDDM
SO PLOS ONE
LA English
DT Article
ID SPONTANEOUSLY DIABETIC RATS; INCREASED OXIDATIVE STRESS;
   NECROSIS-FACTOR-ALPHA; SMOOTH-MUSCLE-CELLS; NITRIC-OXIDE; DECREASED
   SUSCEPTIBILITY; PERIPHERAL NEUROPATHY; METABOLIC SYNDROME;
   BASEMENT-MEMBRANE; GENE-EXPRESSION
AB Background: Cardiovascular disease is the leading cause of mortality in diabetics, and it has a complex etiology that operates on several levels. Endothelial dysfunction and increased generation of reactive oxygen species are believed to be an underlying cause of vascular dysfunction and coronary artery disease in diabetes. This impairment is likely the result of decreased bioavailability of nitric oxide (NO) within the vasculature. However, it is unclear whether hyperglycemia per se stimulates NADPH oxidase-derived superoxide generation in vascular tissue.
   Methods and Results: This study focused on whether NADPH oxidase-derived superoxide is elevated in vasculature tissue evoking endothelial/smooth muscle dysfunction in the hyperglycemic (169+/-4 mg%) Goto-Kakizaki (GK) rat. By dihydroethidine fluorescence staining, we determined that aorta superoxide levels were significantly elevated in 9 month-old GK compared with age matched Wistar (GK; 195+/-6%, Wistar; 100+/-3.5%). Consistent with these findings, 10(-6) mol/L acetylcholine-induced relaxation of the carotid artery was significantly reduced in GK rats compared with age matched Wistar (GK; 41+/-7%, Wistar; 100+/-5%) and measurements in the aorta showed a similar trend (p = .08). In contrast, relaxation to the NO donor SNAP was unaltered in GK compared to Wistar. Endothelial dysfunction was reversed by lowering of superoxide with apocynin, a specific Nox inhibitor.
   Conclusions: The major findings from this study are that chronic hyperglycemia induces significant vascular dysfunction in both the aorta and small arteries. Hyperglycemic induced increases in NAD(P)H oxidase activity that did not come from an increase in the expression of the NAD(P)H oxidase subunits, but more likely as a result of chronic activation via intracellular signaling pathways.
C1 [Gupte, Sachin; Gupte, Rakhee] Univ S Alabama, Dept Biochem & Mol Biol, Mobile, AL 36688 USA.
   [Csiszar, Anna; Ungvari, Zoltan] Univ Oklahoma, Hlth Sci Ctr, Reynolds Oklahoma Ctr Aging, Oklahoma City, OK USA.
   [Labinskyy, Nazar; Csiszar, Anna; Edwards, John G.] New York Med Coll, Dept Physiol, Valhalla, NY 10595 USA.
C3 University of South Alabama; University of Oklahoma System; University
   of Oklahoma Health Sciences Center; New York Medical College
RP Gupte, S (corresponding author), Univ S Alabama, Dept Biochem & Mol Biol, Mobile, AL 36688 USA.
EM j_edwards@nymc.edu
RI Ungvari, Zoltan/GZK-8127-2022; Edwards, Jeff/P-9759-2016
FU National Institutes of Health [HL077256, HL43023, HL085352]; American
   Heart Association [0435070]
FX Supported by the National Institutes of Health under the following grant
   numbers: HL077256, HL43023, HL085352; as well by the American Heart
   Association (Grant#0435070). These funding agencies had no role in study
   design, data collection and analysis, decision to publish, or
   preparation of the manuscript.
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NR 56
TC 36
Z9 41
U1 0
U2 2
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JUL 26
PY 2010
VL 5
IS 7
AR e11800
DI 10.1371/journal.pone.0011800
PG 8
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 630TN
UT WOS:000280297300026
PM 20668682
OA Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Kaddai, V
   Gonzalez, T
   Bolla, M
   Le Marchand-Brustel, Y
   Cormont, M
AF Kaddai, V.
   Gonzalez, T.
   Bolla, M.
   Le Marchand-Brustel, Y.
   Cormont, M.
TI The nitric oxide-donating derivative of acetylsalicylic acid, NCX 4016,
   stimulates glucose transport and glucose transporters translocation in
   3T3-L1 adipocytes
SO AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
LA English
DT Article
DE nitric oxide donation; adipocytes; glucose transporter translocation;
   S-nitrosylation; diabetes
ID ACTIVATED PROTEIN-KINASE; INSULIN-RESISTANCE; GLUT4 TRANSLOCATION;
   GASTROINTESTINAL SAFETY; ASPIRIN NCX-4016; S-NITROSYLATION; TNF-ALPHA;
   PHOSPHORYLATION; TRAFFICKING; BIOGENESIS
AB NCX 4016 is a nitric oxide (NO)-donating derivative of acetylsalicylic acid. NO and salicylate, in vivo metabolites of NCX 4016, were shown to be potential actors in controlling glucose homeostasis. In this study, we evaluated the action of NCX 4016 on the capacity of 3T3-L1 adipocytes to transport glucose in basal and insulin-stimulated conditions. NCX 4016 induced a twofold increase in glucose uptake in parallel with the translocation of the glucose transporters GLUT1 and GLUT4 to the plasma membrane, leaving unaffected their total expression levels. Importantly, NCX 4016 further increased glucose transport induced by a physiological concentration of insulin. The stimulatory effect of NCX 4016 on glucose uptake appears to be mediated by its NO moiety. Indeed, it is inhibited by a NO scavenger and treatment with acetylsalicylic or salicylic acid had no effect. Although NO is involved in the action of NCX 4016, it did not mainly depend on the soluble cGMP cyclase/protein kinase G pathway. Furthermore, NCX 4016-stimulated glucose transport did not involve the insulin-signaling cascade required to stimulate glucose transport. NCX 4016 induces a small activation of the mitogen-activated protein kinases p38 and c-Jun NH2-terminal kinase and no activation of other stress-activated signaling molecules, including extracellular signal-regulated kinase, inhibitory factor kappa B, or AMP-activated kinases. Interestingly, NCX 4016 modified the content of S-nitrosylated proteins in adipocytes. Taken together, our results indicate that NCX 4016 induced glucose transport in adipocytes through a novel mechanism possibly involving S-nitrosylation. NCX 4016 thus possesses interesting characteristics to be considered as a candidate molecule for the treatment of patients suffering from metabolic syndrome and type 2 diabetes.
C1 [Kaddai, V.; Gonzalez, T.; Le Marchand-Brustel, Y.; Cormont, M.] Univ Nice Sophia Anitpolis, Fac Med, INSERM, U895, F-06204 Nice 3, France.
   [Bolla, M.] NicOx, Sophia Antipolis, France.
   [Le Marchand-Brustel, Y.] Hop Archet, CHU Nice, Serv Hepatol, Nice, France.
C3 Universite Cote d'Azur; Institut National de la Sante et de la Recherche
   Medicale (Inserm); CHU Nice
RP Cormont, M (corresponding author), Univ Nice Sophia Anitpolis, Fac Med, INSERM, U895, Batiment Archimed,151 Route St Antoine Ginestiere, F-06204 Nice 3, France.
EM cormont@unice.fr
OI Gonzalez, Teresa/0000-0001-7558-6833; CORMONT,
   Mireille/0000-0001-6918-2410
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NR 48
TC 18
Z9 20
U1 0
U2 0
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0193-1849
EI 1522-1555
J9 AM J PHYSIOL-ENDOC M
JI Am. J. Physiol.-Endocrinol. Metab.
PD JUL
PY 2008
VL 295
IS 1
BP E162
EP E169
DI 10.1152/ajpendo.00622.2007
PG 8
WC Endocrinology & Metabolism; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Physiology
GA 333HA
UT WOS:000258142400021
PM 18492771
DA 2025-06-11
ER

PT J
AU Bellman, J
   Westerterp, K
   Wouters, L
   Johannesson, M
   Lundqvist, N
   Kullberg, J
   Larsson, C
   Gustafsson, M
   Pettersson, S
   Fridolfsson, J
   Arvidsson, D
   Börjesson, M
   Curiac, D
   Jansson, JO
   Jansson, PA
   Ohlsson, C
AF Bellman, Jakob
   Westerterp, Klaas
   Wouters, Loek
   Johannesson, Marit
   Lundqvist, Niklas
   Kullberg, Joel
   Larsson, Christel
   Gustafsson, Mikael
   Pettersson, Stefan
   Fridolfsson, Jonatan
   Arvidsson, Daniel
   Borjesson, Mats
   Curiac, Dan
   Jansson, John-Olov
   Jansson, Per-Anders
   Ohlsson, Claes
TI Increased weight-load improves body composition by reducing fat mass and
   waist circumference, and by increasing lean mass in participants with
   obesity: a single-centre randomised controlled trial
SO BMC MEDICINE
LA English
DT Article
DE Obesity; Weight-bearing; Weight-loading; Standing position; Body
   composition; Fat mass distribution; Energy balance
ID ENERGY-EXPENDITURE; METABOLIC SYNDROME; RESISTANCE; EXERCISE;
   HYPERTROPHY; STRESS
AB BackgroundTo investigate the effects of increased weight-loading on body weight, body composition, fat mass distribution, physical activity and energy balance in individuals with obesity.MethodsThis single-centre non-blinded randomised controlled trial was conducted from August 1, 2021, through February 28, 2022. Adults with obesity class 1 (body mass index, BMI 30-35 kg/m2) were assigned to wear either a heavy (high load; 11% of body weight, n = 28) or light (low load; 1% of body weight, n = 30) weight vest for 8 h per day over 5 weeks.ResultsHigh-load treatment reduced fat mass (mean difference - 2.60%; 95% CI - 3.79, - 1.41) and increased lean mass (mean difference 1.40%; 95% CI 0.37, 2.42), with no significant effect on body weight. Fat mass reductions were primarily observed in weight-loaded regions but not in the non-weight-bearing regions such as the arms. Waist circumference decreased (mean difference - 2.26%; 95% CI - 3.81, - 0.71) in the high-load group compared to the low-load group. Despite these beneficial changes, sedentary time was higher in the high-load group (mean difference 4.69%; 95% CI 0.98, 8.39) compared to the low-load group, while energy expenditure and energy intake remained unchanged.ConclusionsIncreased weight-loading reduced fat mass and increased lean mass, resulting in a healthier body composition. These effects were achieved despite no increase in physical activity. The fat mass-reducing effect was primarily seen in weight-loaded regions, implying local adaptation to the increased loading.Trial registrationRegistered at ClinicalTrials.gov (NCT04697238) in 2021.
C1 [Bellman, Jakob; Jansson, John-Olov] Univ Gothenburg, Inst Neurosci & Physiol, Dept Physiol, Sahlgrenska Acad, Medicinaregatan 11, SE-41390 Gothenburg, Sweden.
   [Westerterp, Klaas; Wouters, Loek] Maastricht Univ, Med Ctr, NUTRIM Sch Nutr & Translat Res Metab, Dept Nutr & Movement Sci, NL-6200 MD Maastricht, Netherlands.
   [Johannesson, Marit; Lundqvist, Niklas] Sahlgrens Univ Hosp, Dept Radiol, Reg Vastra Gotaland, SE-41345 Gothenburg, Sweden.
   [Kullberg, Joel] Uppsala Univ, Dept Surg Sci, Radiol, SE-75185 Uppsala, Sweden.
   [Kullberg, Joel] Antaros Med, SE-43153 Molndal, Sweden.
   [Larsson, Christel; Gustafsson, Mikael; Pettersson, Stefan; Fridolfsson, Jonatan; Arvidsson, Daniel; Borjesson, Mats] Univ Gothenburg, Dept Food & Nutr & Sport Sci, Fac Educ, SE-40530 Gothenburg, Sweden.
   [Borjesson, Mats] Sahlgrens Univ Hosp, Dept Med Geriatr & Acute Med, Reg Vastra Gotaland, SE-41685 Gothenburg, Sweden.
   [Curiac, Dan; Jansson, Per-Anders] Sahlgrens Univ Hosp, Gothia Forum, Reg Vastra Gotaland, SE-41346 Gothenburg, Sweden.
   [Jansson, Per-Anders] Univ Gothenburg, Inst Med, Dept Mol & Clin Med, Wallenberg Lab,Sahlgrenska Acad, SE-41345 Gothenburg, Sweden.
   [Ohlsson, Claes] Univ Gothenburg, Sahlgrenska Acad, Sahlgrenska Osteoporosis Ctr, Ctr Bone & Arthrit Res,Inst Med, SE-41345 Gothenburg, Sweden.
   [Ohlsson, Claes] Sahlgrens Univ Hosp, Dept Drug Treatment, Reg Vastra Gotaland, SE-41345 Gothenburg, Sweden.
C3 University of Gothenburg; Maastricht University; Maastricht University
   Medical Centre (MUMC); Sahlgrenska University Hospital; Uppsala
   University; University of Gothenburg; Sahlgrenska University Hospital;
   Sahlgrenska University Hospital; University of Gothenburg; University of
   Gothenburg; Sahlgrenska University Hospital
RP Bellman, J (corresponding author), Univ Gothenburg, Inst Neurosci & Physiol, Dept Physiol, Sahlgrenska Acad, Medicinaregatan 11, SE-41390 Gothenburg, Sweden.
EM jakob.bellman@gu.se
RI Arvidsson, Daniel/AAZ-9362-2021; Fridolfsson, Jonatan/KUD-5944-2024;
   Kullberg, Joel/ABE-3997-2021; Ohlsson, Claes/HIR-6959-2022
FU ALF-agreement
FX The authors thank the contribution of the personnel at the Clinical
   Trial Center, Gothia Forum, Sahlgrenska University Hospital for their
   excellent assistance during the study and the participants who
   participated. Fig. 2 created with publication rights from BioRender.com.
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NR 65
TC 0
Z9 0
U1 0
U2 0
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1741-7015
J9 BMC MED
JI BMC Med.
PD MAY 30
PY 2025
VL 23
IS 1
AR 317
DI 10.1186/s12916-025-04143-6
PG 12
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 3FU3F
UT WOS:001499301600003
PM 40442671
DA 2025-06-11
ER

PT J
AU Cholidou, K
   Anagnostopoulos, N
   Bartziokas, K
   Vafeiadis, K
   Bakakos, A
   Vontetsianos, A
   Gogou, V
   Sotiropoulou, Z
   Anagnostopoulou, C
   Papasarantou, A
   Steiropoulos, P
   Bakakos, P
   Papaioannou, AI
AF Cholidou, Kyriaki
   Anagnostopoulos, Nektarios
   Bartziokas, Konstantinos
   Vafeiadis, Konstantinos
   Bakakos, Agamemnon
   Vontetsianos, Aggelos
   Gogou, Vasiliki
   Sotiropoulou, Zoi
   Anagnostopoulou, Christina
   Papasarantou, Anna
   Steiropoulos, Paschalis
   Bakakos, Petros
   Papaioannou, Andriana I.
TI Correlation of mean platelet volume and red blood cell distribution
   width with obstructive sleep apnoea syndrome severity
SO LUNG INDIA
LA English
DT Article
DE Biomarkers; mean platelet volume; obstructive sleep apnoea syndrome; red
   blood cell distribution width; severity
ID OXIDATIVE STRESS; CARDIOVASCULAR COMPLICATIONS; METABOLIC SYNDROME;
   INFLAMMATION; INDEXES; MARKER
AB Introduction:Mean platelet volume (MPV) and red blood cll distribution width (RDW) have been assosiated with sleep apnea syndrome severity. Objective:To investigate the correlation of mean platelet volume and red blood cell distribution width with obesity sleep apnoea syndrome (OSAS) severity. Methods:Ninety patients underwent PSG. Patients with an apnoea-hypopnoea index (AHI) <5 were used as controls. Patients with AHI >5 were divided into mild: 5 <= AHI <15, moderate: 15 <= AHI <30 and severe OSAS: AHI >= 30. Patients >65 years, with body mass index (BMI) >40, central sleep apnoea syndrome, cardiovascular or other significant comorbidities were excluded. Blood sample collection occurred one day before polysomnography (PSG). Results:Sixty-four patients were included in our study. Fifty-seven (89.1%) had OSAS (16% mild, 25% moderate and 48.4% severe) while the remaining 7 (10.1%) were used as controls. MPV was similar among groups [8.1 (7.1, 9.2) vs 7.9 (6.8, 10.1) vs 8.5 (7.4, 9.1) vs 8.4 (7.6, 9.7), P = .930 for control, mild, moderate and severe OSAS, respectively]. RDW did not differ between OSAS patients and control [median (IQR) 14.4 (13.4, 15.3) vs 14.0 (13.5, 16.7), P = .950], while there was no significant difference among different stages of OSAS severity [14.0 (13.5, 16.7) vs 13.9 (11.4, 14.8) vs 14.4 (14.0, 15.3) vs 14.4 (13.3, 15.6), P = .517] for control, mild, moderate and severe OSAS, respectively. Conclusion:OSAS patients have elevated levels of RDW and MPV compared to controls; however, there was no association between OSAS severity and MPV or RDW.
C1 [Cholidou, Kyriaki; Anagnostopoulos, Nektarios; Vafeiadis, Konstantinos; Bakakos, Agamemnon; Vontetsianos, Aggelos; Gogou, Vasiliki; Sotiropoulou, Zoi; Anagnostopoulou, Christina; Papasarantou, Anna; Bakakos, Petros; Papaioannou, Andriana I.] Natl & Kapodistrian Univ Athens, Sotiria Chest Dis Hosp, Med Sch, Resp Med Dept 1, Athens, Greece.
   [Steiropoulos, Paschalis] Democritus Univ Thrace, Med Sch, Dept Resp Med, Alexandroupolis, Greece.
C3 National & Kapodistrian University of Athens; Democritus University of
   Thrace
RP Cholidou, K (corresponding author), Natl & Kapodistrian Univ Athens, Sotiria Chest Dis Hosp, Med Sch, Resp Med Dept 1, Athens, Greece.
EM bartziokas@gmail.com
RI Bakakos, Agamemnon/AIC-5517-2022
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NR 29
TC 0
Z9 0
U1 0
U2 0
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, Maharashtra, INDIA
SN 0970-2113
EI 0974-598X
J9 LUNG INDIA
JI Lung India
PD MAY-JUN
PY 2025
VL 42
IS 3
BP 179
EP 185
DI 10.4103/lungindia.lungindia_422_24
PG 7
WC Respiratory System
WE Emerging Sources Citation Index (ESCI)
SC Respiratory System
GA 2AY9R
UT WOS:001478344700013
PM 40296387
DA 2025-06-11
ER

PT J
AU Jiang, L
   Jian, J
   Sai, X
   Yu, HD
   Liang, WX
   Wu, XI
AF Jiang, Li
   Jian, Jie
   Sai, Xulin
   Yu, Hongda
   Liang, Wanxian
   Wu, Xiai
TI Oxidative balance is associated with diabetic kidney disease and
   mortality in adults with diabetes mellitus: Insights from NHANES
   database and Mendelian randomization
SO JOURNAL OF DIABETES INVESTIGATION
LA English
DT Article; Early Access
DE Cross-sectional analysis; Diabetic kidney disease; Oxidative Balance
   Score
ID STRESS
AB Objective: To explore and validate the association between the oxidative balance and prevalence of diabetic kidney disease (DKD) and mortality in patients with diabetes. Study design: A large and representative sample from the National Health and Nutrition Examination Survey (NHANES) from 2013 to 2016 was analyzed to study the potential association between Oxidative Balance Score (OBS) and prognosis of DKD in adult diabetic patients. Weighted multivariate logistic regression analysis was conducted to examine the relationship between OBS and DKD risk. Subgroup analysis, sensitivity analysis, and mediation effect analysis were conducted to explore the effect of the covariates and assess the robustness of the findings. Mendelian randomization (MR) was employed to evaluate the correlated relationship between mitochondrial reactive oxygen species (ROS) levels and DKD at the genetic level. Result: The highest OBS quartile showed the most significant negative correlation with DKD compared to the lowest OBS quartile (OR = 0.62, 95% CI 0.41-0.92, P = 0.017). Higher OBS was associated with a reduced risk of DKD (OR = 0.96; 95% CI = 0.93, 0.98; P < 0.001) and mortality (P = 0.021 by log-rank) in diabetic patients. This association remained robust even after excluding individual OBS components. Subgroup analysis revealed the interaction of metabolic syndrome on OBS was significant. Mediation analyses revealed that OBS's effect on DKD was independent of blood uric acid and cholesterol. Restricted cubic spline (RCS) analysis indicated a typical L-shaped relationship between OBS and DKD risk. The physical activity was identified as the core variable predicting DKD risk by two machine learning algorithms. MR showed a potential correlated relationship between ROS and microalbuminuria in DKD. Conclusions: The high level of oxidative balance score was negatively correlated with the risk of DKD and mortality in diabetic patients.
C1 [Jiang, Li; Wu, Xiai] China Japan Friendship Hosp, Diabet Dept Integrated Chinese & Western Med, Beijing, Peoples R China.
   [Jiang, Li; Wu, Xiai] China Natl Ctr Integrated Tradit Chinese & Western, Beijing, Peoples R China.
   [Jian, Jie] Mental Hlth Ctr Dongcheng Dist, Beijing, Peoples R China.
   [Sai, Xulin] Beijing Univ Chinese Med, Dongzhimen Hosp, Beijing, Peoples R China.
   [Yu, Hongda] China Japan Friendship Hosp, China Natl Ctr Integrated Tradit Chinese & Western, Dept Dermatol, Beijing, Peoples R China.
   [Liang, Wanxian] Beijing Univ Chinese Med, Ctr Evidence Based Chinese Med, Beijing, Peoples R China.
C3 China-Japan Friendship Hospital; Beijing University of Chinese Medicine;
   China-Japan Friendship Hospital; Beijing University of Chinese Medicine
RP Wu, XI (corresponding author), China Japan Friendship Hosp, Diabet Dept Integrated Chinese & Western Med, Beijing, Peoples R China.; Wu, XI (corresponding author), China Natl Ctr Integrated Tradit Chinese & Western, Beijing, Peoples R China.
EM 20180931313@bucm.edu.cn
OI Jiang, Li/0000-0003-3827-2178
FU National High Level Hospital Clinical Research Funding
FX All authors would like to thank the public and shared data set from the
   NHANES and GWAS databases and express gratitude for the funding.
CR Burgess Stephen, 2019, Wellcome Open Res, V4, P186, DOI 10.12688/wellcomeopenres.15555.3
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NR 38
TC 0
Z9 0
U1 2
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2040-1116
EI 2040-1124
J9 J DIABETES INVEST
JI J. Diabetes Investig.
PD 2024 DEC 26
PY 2024
DI 10.1111/jdi.14390
EA DEC 2024
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA Q5C1H
UT WOS:001384848700001
PM 39724381
OA gold
DA 2025-06-11
ER

PT J
AU Song, NZ
   Xu, HJ
   Wu, SH
   Luo, SJ
   Xu, JY
   Zhao, Q
   Wang, R
   Jiang, XX
AF Song, Nazi
   Xu, Hongjiao
   Wu, Shuohan
   Luo, Suijia
   Xu, Jingyao
   Zhao, Qian
   Wang, Rui
   Jiang, Xianxing
TI Synergistic activation of AMPK by AdipoR1/2 agonist and inhibitor of
   EDPs-EBP interaction recover NAFLD through enhancing mitochondrial
   function in mice
SO ACTA PHARMACEUTICA SINICA B
LA English
DT Article
DE NASH; Liver fibrosis; Combination therapy; Mitochondrial function;
   Mitophagy; Mitochondrial biogenesis; AMPK; EDPs; AdipoR1; 2 agonist
ID NONALCOHOLIC FATTY LIVER; BREAST-CANCER CELLS; PPAR-ALPHA; ADIPONECTIN;
   STEATOHEPATITIS; THERAPEUTICS; METABOLISM; MECHANISMS; STEATOSIS;
   MITOPHAGY
AB Nonalcoholic fatty liver disease (NAFLD), especially nonalcoholic steatohepatitis (NASH), is a common hepatic manifestation of metabolic syndrome. However, there are no effective therapy to treat this devastating disease. Accumulating evidence suggests that the generation of elastin-derived peptides (EDPs) and the inhibition of adiponectin receptors (AdipoR)1/2 plays essential roles in hepatic lipid metabolism and liver fibrosis. We recently reported that the AdipoR1/2 dual agonist JT003 significantly degraded the extra -cellular matrix (ECM) and ameliorated liver fibrosis. However, the degradation of the ECM lead to the gener-ation of EDPs, which could further alter liver homeostasis negatively. Thus, in this study, we successfully combined AdipoR1/2 agonist JT003 with V14, which acted as an inhibitor of EDPs-EBP interaction to over-come the defect of ECM degradation. We found that combination of JT003 and V14 possessed excellent syn-ergistic benefits on ameliorating NASH and liver fibrosis than either alone since they compensate the shortage of each other. These effects are induced by the enhancement of the mitochondrial antioxidant capacity, mito-phagy, and mitochondrial biogenesis via AMPK pathway. Furthermore, specific suppression of AMPK could block the effects of the combination of JT003 and V14 on reduced oxidative stress, increased mitophagy and mitochondrial biogenesis. These positive results suggested that this administration of combination of Adi-poR1/2 dual agonist and inhibitor of EDPs-EBP interaction can be recommended alternatively for an effective and promising therapeutic strategy for the treatment of NAFLD and NASH related fibrosis. 2023 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sci-ences. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
C1 [Song, Nazi; Xu, Hongjiao; Wu, Shuohan; Xu, Jingyao; Zhao, Qian; Jiang, Xianxing] Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 511400, Peoples R China.
   [Wang, Rui] Chinese Acad Med Sci & Peking Union Med Coll, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China.
   [Wang, Rui] Lanzhou Univ, Sch Life Sci, Sch Basic Med Sci, Key Lab Preclin Study New Drugs Gansu Prov, Lanzhou 730000, Peoples R China.
   [Wang, Rui] Lanzhou Univ, Res Unit Peptide Sci, Lanzhou 730000, Peoples R China.
   [Luo, Suijia] Shenzhen Turier Biotech Co Ltd, Shenzhen 518118, Peoples R China.
C3 Sun Yat Sen University; Chinese Academy of Medical Sciences - Peking
   Union Medical College; Peking Union Medical College; Lanzhou University;
   Lanzhou University
RP Jiang, XX (corresponding author), Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 511400, Peoples R China.; Wang, R (corresponding author), Chinese Acad Med Sci & Peking Union Med Coll, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China.; Wang, R (corresponding author), Lanzhou Univ, Sch Life Sci, Sch Basic Med Sci, Key Lab Preclin Study New Drugs Gansu Prov, Lanzhou 730000, Peoples R China.; Wang, R (corresponding author), Lanzhou Univ, Res Unit Peptide Sci, Lanzhou 730000, Peoples R China.
EM wangrui@lzu.edu.cn; jiangxx5@mail.sysu.edu.cn
RI zhao, qian/KHX-7368-2024; wang, rui/JAC-6240-2023; Wu,
   Shuohan/MSV-6034-2025; JIANG, xx/KHV-3752-2024; Xu,
   Jingyao/GQB-0952-2022
FU National Natural Science Foundation of China [91853106, 81870420,
   82070590]; Program for Guangdong Introducing Innovative and
   Enterpreneurial Teams (China) [2016ZT06Y337]; Fundamental Research Funds
   for the Central Universities (China) [19ykzd25]; National Key Research
   and Development Program (China) [2017YFE0109900]; Special Topics of
   General Projects of Guangzhou Science and Technology Plan of China
   [201904010075]; CAMS Innovation Fund for Medical Sciences (CIFMS, China)
   [2019-I2M-5-074]
FX We appreciate the financial support from the National Natural Science
   Foundation of China (Nos. 91853106, 81870420 and 82070590); the Program
   for Guangdong Introducing Innovative and Enterpreneurial Teams (No.
   2016ZT06Y337, China); The Fundamental Research Funds for the Central
   Universities (No. 19ykzd25, China); National Key Research and
   Development Program (No. 2017YFE0109900, China) and Special Topics of
   General Projects of Guangzhou Science and Technology Plan of China
   (201904010075); CAMS Innovation Fund for Medical Sciences (CIFMS,
   2019-I2M-5-074, China).
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NR 50
TC 14
Z9 14
U1 0
U2 32
PU INST MATERIA MEDICA, CHINESE ACAD MEDICAL SCIENCES
PI BEIJING
PA C/O EDITORIAL BOARD OF ACTA PHARMACEUTICA SINICA, 1 XIANNONGTAN ST,
   BEIJING, 100050, PEOPLES R CHINA
SN 2211-3835
EI 2211-3843
J9 ACTA PHARM SIN B
JI Acta Pharm. Sin. B
PD FEB
PY 2023
VL 13
IS 2
BP 542
EP 558
DI 10.1016/j.apsb.2022.10.003
EA FEB 2023
PG 17
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 9Q1DF
UT WOS:000944712000001
PM 36873175
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Sokan-Adeaga, AA
   Sokan-Adeaga, MA
   Sokan-Adeaga, ED
   Oparaji, AN
   Edris, H
   Tella, EO
   Balogun, FA
   Aledeh, M
AF Sokan-Adeaga, Adewale Allen
   Sokan-Adeaga, Micheal Ayodeji
   Sokan-Adeaga, Eniola Deborah
   Oparaji, Anastasia Nkem
   Edris, Hoseinzadeh
   Tella, Esther Oluwabukunola
   Balogun, Francis Adeniyi
   Aledeh, Muhammad
TI Environmental toxicants and health adversities: A review on
   interventions of phytochemicals
SO MODERN PHYTOMORPHOLOGY
LA English
DT Review
DE Environmental toxicants; Phytochemicals; Prophylactics; Therapeutics;
   Plants; Intervention; Medicinal properties; Public health; Plant
   biology; Phytosozology; Phytogeography
ID POLYCYCLIC AROMATIC-HYDROCARBONS; TEA TREE OIL; POLYUNSATURATED
   FATTY-ACIDS; OXIDATIVE STRESS; PROSTATE-CANCER; DOUBLE-BLIND;
   ANTIOXIDANT PROPERTIES; PYRETHROID PESTICIDE; METABOLIC SYNDROME;
   PHENOLIC-COMPOUNDS
AB Toxicity arising from environmental contaminants has attracted global interest in the last few decades, due to the high morbidity and mortality associated with it. Efforts have been made to combat the consequential outcomes of environmental toxicity in humans through traditional remediation techniques and therapeutic measures that have been hampered by one or more limitations. Consequently, this scenario has triggered interest in the medicinal properties of phytochemicals. Thus, this desk review gives a succinct and in-depth overview of environmental contaminants and their toxicity effects on humans. The classes of phytochemicals and their functions are investigated. This study adopted a desk review of existing literatures from scientific reports and peer-reviewed articles through triangulation of data sources. Environmental contaminants exist as organic, inorganic and radioactive substances; and are generated from natural and anthropogenic activities. Classes of toxicants considered include heavy metals, pesticides, food additives, solvents, cosmetics, combustion products and drugs of abuse. They become inimical to the ecosystem and pose danger to humans' health when exposed to or bioaccumulated beyond the threshold limits. On the other side "Phytochemicals" are group of secondary metabolites obtained from plants with medicinal properties. These compounds include flavonoids, tannins, saponins, alkaloids, cardenoloids, terpenoids, and phytosteroids. This review corroborates the prophylactic and therapeutics efficacy of these phytochemicals as anti -metastatic, anti-inflammatory, anti-ageing, anti-oxidant, anti-microbial and life-saving substances with empirical findings from several laboratories, clinical trials and epidemiologic studies. In this article, we argue that, despite phytochemicals' effectiveness in preventing and treating many diseases in humans caused by environmental toxicity, their over-exploitation, and unsustainably high consumption should be strictly avoided.
C1 [Sokan-Adeaga, Adewale Allen; Tella, Esther Oluwabukunola] Lead City Univ, Fac Publ Hlth, Dept Environm Hlth Sci, Coll Med, Ibadan, Nigeria.
   [Sokan-Adeaga, Micheal Ayodeji] Univ Lagos, Fac Clin Sci, Dept Community Hlth & Primary Hlth Care, Coll Med, Lagos, Nigeria.
   [Sokan-Adeaga, Eniola Deborah] Ladoke Akintola Univ Technol LAUTECH, Dept Physiol, Coll Med, Fac Basic Med Sci, Ogbomosho, Oyo State, Nigeria.
   [Oparaji, Anastasia Nkem] Chrisland Univ, Dept Nursing Sci, Abeokuta, Ogun State, Nigeria.
   [Edris, Hoseinzadeh] Saveh Univ Med Sci, Incubat & Innovat Ctr, Saveh, Iran.
   [Balogun, Francis Adeniyi] Lead City Univ, Fac Publ Hlth, Dept Community Hlth, Coll Med, Ibadan, Nigeria.
   [Aledeh, Muhammad] Univ Derby, Coll Hlth Psychol & Social Care, Derby, England.
   [Aledeh, Muhammad] Klin Donaustadt, Wiener Gesundheitsverbund, Dept Psychiat, Langobardenstr 122, AT-1200 Vienna, Austria.
C3 University of Lagos; University of Derby
RP Sokan-Adeaga, AA (corresponding author), Lead City Univ, Fac Publ Hlth, Dept Environm Hlth Sci, Coll Med, Ibadan, Nigeria.
EM adewaleallen@yahoo.com
RI SOKAN-ADEAGA, MICHEAL/ABC-6735-2022; SOKAN-ADEAGA, Dr.
   ADEWALE/AAO-6199-2020; Aledeh, Muhammad/GRY-6487-2022; SOKAN-ADEAGA,
   ENIOLA/AEO-2438-2022
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NR 169
TC 0
Z9 0
U1 1
U2 5
PU STATE NATURAL HISTORY MUSEUM NAS UKRAINE
PI LVIV
PA VUL DOROSHENKA, 41, LVIV, 79000, UKRAINE
SN 2226-3063
EI 2227-9555
J9 MOD PHYTOL
JI Mod. Phytol.
PY 2023
VL 17
BP 1
EP 19
DI 10.5281/zenodo.2023-17-200117
PG 19
WC Plant Sciences
WE Emerging Sources Citation Index (ESCI)
SC Plant Sciences
GA WP9N5
UT WOS:001256196100001
DA 2025-06-11
ER

PT J
AU Lin, YC
   Lin, YW
AF Lin, Yu-Cheng
   Lin, Yu-Wen
TI An Index to Assess Overwork-Related Adverse Effects on Employees Under
   the Occupational Safety and Health Act in Taiwan
SO SAFETY AND HEALTH AT WORK
LA English
DT Article
DE Cerebrocardiovascular disease; Karo index; Occupational health service;
   Overwork; Risk assessment
ID LONG WORKING HOURS; METABOLIC SYNDROME; HEART-DISEASE; BURNOUT; STRESS;
   RISK; WORKERS; STROKE; IMPACT
AB Background: The present study aimed to digitally evaluate the risk of overwork-related adverse effects (OrAEs) among employees from various occupational categories in Taiwan.
   Methods: Anonymous data of employees from seven companies/factories providing occupational health services were analyzed. The studied population comprised 5505 employees, and the data analyzed included employment duration, working hours, shift work schedules, and health checkup results. The risk for OrAEs was assessed by an index, Karo index (0-4, the larger the value, the higher the risk for OrAEs) obtained using a risk matrix made up of cardiocerebral and occupational risk factors. Karo index values of 3 and 4 were categorized as at high risk for OrAEs (h-OrAEs).
   Results: The 5505 employees had an average employment duration of 8.5 years and a mean age of 39.4 years. The prevalence rates for h-OrAEs of the seven companies/factories ranged from 3.9% to 34.2%. There were significant differences in prevalence rates for h-OrAEs between employees of retail stores and high-tech manufacturing factories. Multivariate analysis results indicated that workers of high-tech manufacturing factories had significantly higher risk for h-OrAEs compared with retail store workers.
   Conclusion: In terms of satisfying health risk management and legal requirements in Taiwan, the newly issued Karo index, which covers a wide range of occupational risk factors, can serve as an assessment and a warning tool for managing the risk of OrAEs in workplaces. To reduce risks for h-OrAEs, active and prudent control of cerebrocardiovascular risks and working hours is recommended. (c) 2022 Occupational Safety and Health Research Institute, Published by Elsevier Korea LLC. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
C1 [Lin, Yu-Cheng] Fu Jen Catholic Univ, Fu Jen Catholic Univ Hosp, Dept Occupat Med, New Taipei, Taiwan.
   [Lin, Yu-Cheng] Fu Jen Catholic Univ, Sch Med, New Taipei, Taiwan.
   [Lin, Yu-Cheng] Chu Kong Hosp, Dept Occupat Med, New Taipei, Taiwan.
   [Lin, Yu-Wen] Fu Jen Catholic Univ, Coll Med, New Taipei, Taiwan.
C3 Fu Jen Catholic University; Fu Jen Catholic University Hospital; Fu Jen
   Catholic University; Fu Jen Catholic University
RP Lin, YC (corresponding author), Fu Jen Catholic Univ, Fu Jen Catholic Univ Hosp, Dept Occupat Med, New Taipei, Taiwan.
EM shiftwork.lin@gmail.com
RI 林, 煜程/HSI-3146-2023
OI Lin, Yu-Wen/0000-0002-7643-6869; Lin, Yu Cheng/0000-0003-4648-8745
FU Fu Jen Catholic University Hospital [PL-201808004-V]; En Chu Kong
   Hospital [ECKIRB1040501]
FX The authors express their appreciation to the temporary personnel of the
   research teams supported by the Fu Jen Catholic University Hospital
   (Grant No.: PL-201808004-V) and the En Chu Kong Hospital (Grant No.:
   ECKIRB1040501).
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NR 49
TC 5
Z9 5
U1 2
U2 8
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2093-7911
EI 2093-7997
J9 SAF HEALTH WORK-KR
JI Saf. Health Work
PD DEC
PY 2022
VL 13
IS 4
BP 401
EP 407
DI 10.1016/j.shaw.2022.10.002
EA DEC 2022
PG 7
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA 7N9GC
UT WOS:000907642800005
PM 36579013
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Ghazvineh, D
   Daneshvar, M
   Basirat, V
   Daneshzad, E
AF Ghazvineh, Dorsa
   Daneshvar, Mojtaba
   Basirat, Vahid
   Daneshzad, Elnaz
TI The Effect of Yoga on the Lipid Profile: A Systematic Review and
   Meta-Analysis of Randomized Clinical Trials
SO FRONTIERS IN NUTRITION
LA English
DT Review
DE yoga; exercise; lipid profile; systematic review; meta-analysis
ID LIFE-STYLE MODIFICATION; METABOLIC SYNDROME; RISK-FACTORS; EXERCISE
   PROGRAM; RESTORATIVE YOGA; BLOOD-PRESSURE; TYPE-2; ADULTS; DISEASE;
   WOMEN
AB Objectives: Yoga is a mind-body stress-relieving exercise that increases mental and physical health, which may have a role in the improvement of metabolic disorders. The present study has reviewed the effect of yoga on lipid profiles as a systematic review and meta-analysis. Methods: We evaluated the available randomized controlled trials on the effects of yoga-based programs, and lipid profiles by searching PubMed/Medline, Scopus, Web of Science, and the Cochrane central register of control trials up to January 2022. Both fixed and random effect analyses were used to find the relationships. Subgroup analysis was performed based on the continent, duration of the included studies, gender, and health condition of participants to discover the sources of heterogeneity. Result: Fifty-three studies were included in the current systematic review and meta-analysis with a total sample size of 13,191. There was a striking association between yoga and total cholesterol (-10.31 mg/dl; 95% CI: -14.16, -6.45; I-2 = 82.5%, P < 0.001), low-density lipoprotein cholesterol (-8.64 mg/dl; 95% CI: -12.03, -5.25; I-2 = 75.0%, P < 0.001), high-density lipoprotein cholesterol (1.98 mg/dl; 95% CI: 0.81, 3.14; I-2 = 91.6%, P < 0.001), triglycerides (-13.50 mg/dl; 95% CI: -20.09, -6.92; I-2 = 90.7%, P < 0.001) and very low-density lipoprotein (-3.94 mg/dl; 95%CI: -6.31, -1.56; I-2 = 72.2%, P < 0.001). Conclusion: It seems yoga interventions had a substantial effect on lipid profiles, however, more qualified trials or cohort studies are needed to conclude exactly.
C1 [Ghazvineh, Dorsa] Islamic Azad Univ Karaj, Dept Phys Educ, Karaj, Iran.
   [Daneshvar, Mojtaba] Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Community Nutr, Tehran, Iran.
   [Basirat, Vahid] Isfahan Univ Med Sci & Hlth Serv, Sch Med, Dept Gastroenterol, Esfahan, Iran.
   [Daneshzad, Elnaz] Alborz Univ Med Sci, Noncommunicable Dis Res Ctr, Karaj, Iran.
C3 Islamic Azad University; Tehran University of Medical Sciences; Isfahan
   University of Medical Sciences; Alborz University of Medical Sciences
RP Daneshzad, E (corresponding author), Alborz Univ Med Sci, Noncommunicable Dis Res Ctr, Karaj, Iran.
EM daneshzad@gmail.com
RI daneshvar, mojtaba/HGE-5717-2022; Daneshzad, Elnaz/O-3694-2018
OI Daneshvar, Mojtaba/0000-0002-2217-4867
FU Alborz University of Medical Sciences [103-4530]
FX Funding This study was supported by Alborz University of Medical
   Sciences (103-4530).
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NR 74
TC 10
Z9 10
U1 0
U2 4
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD JUL 14
PY 2022
VL 9
AR 942702
DI 10.3389/fnut.2022.942702
PG 16
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 3K5KM
UT WOS:000834114500001
PM 35911119
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Jochems, SHJ
   Haggstrom, C
   Stattin, P
   Jarvholm, B
   Stocks, T
AF Jochems, Sylvia H. J.
   Haggstrom, Christel
   Stattin, Par
   Jarvholm, Bengt
   Stocks, Tanja
TI Association of Blood Pressure with Prostate Cancer Risk by Disease
   Severity and Prostate Cancer Death: A Pooled Cohort Study
SO CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
LA English
DT Article
ID METABOLIC SYNDROME; OXIDATIVE STRESS; MORTALITY; REGISTER; SWEDEN;
   METAANALYSIS; POPULATION; RECURRENCE; REGRESSION; MORBIDITY
AB Background: The association of blood pressure (BP) with prostate cancer risk after accounting for asymptomatic prostate-specific antigen (PSA) testing, and with prostate cancer death, is unclear. Methods: We investigated BP, measured at a mean age of 38 years among 430,472 men from five Swedish cohorts, in association with incident prostate cancer (n = 32,720) and prostate cancer death (n = 6718). HRs were calculated from multivariable Cox regression models. Results: Increasing systolic and diastolic BP levels combined were associated with a slightly lower prostate cancer risk, with a HR of 0.98 (95% CI, 0.97-0.99) per standard deviation (SD) of mid-BP (average of systolic and diastolic BP). The association was restricted to the PSA era (1997 onwards, HR, 0.96; 95% CI, 0.95-0.98), to diagnoses initiated by a PSA test in asymptomatic men (HR, 0.95; 95% CI, 0.93-0.97), and to low-risk prostate cancer (HR, 0.95; 95% CI, 0.92-0.97). There was no clear association with more advanced disease at diagnosis. In cases, a slightly higher risk of prostate cancer death was observed for higher BP levels (HR, 1.05; 95% CI, 1.01-1.08) per SD of mid-BP; however, the association was restricted to distant metastatic disease (Pheterogeneity between case groups = 0.01), and there was no association for BP measured less than 10 years prior to diagnosis. Conclusions: Prediagnostic BP is unlikely an important risk factor for prostate cancer development and death. Less asymptomatic PSA testing among men with higher BP levels may explain their lower risk of prostate cancer. Impact: Elevated BP is unlikely to be an important risk factor for prostate cancer.
C1 [Jochems, Sylvia H. J.; Stocks, Tanja] Lund Univ, Dept Clin Sci Lund, Lund, Sweden.
   [Haggstrom, Christel] Umea Univ, Northern Register Ctr, Dept Publ Hlth & Clin Med, Umea, Sweden.
   [Haggstrom, Christel; Stattin, Par] Uppsala Univ, Dept Surg Sci, Uppsala, Sweden.
   [Jarvholm, Bengt] Umea Univ, Dept Publ Hlth & Clin Med, Umea, Sweden.
   [Stocks, Tanja] Lund Univ, Dept Clin Sci Lund, Barngatan 4, SE-22185 Lund, Sweden.
C3 Lund University; Umea University; Uppsala University; Umea University;
   Lund University
RP Stocks, T (corresponding author), Lund Univ, Dept Clin Sci Lund, Barngatan 4, SE-22185 Lund, Sweden.
EM tanja.stocks@med.lu.se
RI Stocks, Tanja/HPE-5538-2023
OI Jochems, Sylvia/0000-0001-7676-1488; Stocks, Tanja/0000-0002-0904-0557;
   jarvholm, bengt/0000-0002-8169-8820
FU Swedish Research Council [VR 2017-00650, 2015-02332, 2018-02825]; Lund
   University Infrastructure grant [STYR 2019/2046]; Swedish Cancer Society
   [CAN 2017/1019]; Cancer Research Foundation at the Department of
   Oncology, Malmo University Hospital, Sweden; Swedish Research Council
   [2015-02332, 2018-02825] Funding Source: Swedish Research Council
FX We thank the Construction Workers Cohort (Bygghalsan) for providing
   extensive data to the study. We thank the Biobank Research Unit at Umea
   University, the Vasterbotten Intervention Programme, the Northern Sweden
   MONICA study, and the County Council of Vasterbotten for providing data,
   and acknowledgethe contribution of Biobank Sweden, supported by the
   Swedish Research Council (VR 2017-00650). We also thank Anders Dahlin,
   database manager of the MDCS and MPP cohorts, and further acknowledgethe
   support of these cohorts by a Lund University Infrastructure grant (STYR
   2019/2046). We thank the National Prostate Cancer Register of Sweden
   (NPCR) steering group: Par Stattin (chairman), Ingela Franck Lissbrant
   (co-chair), Camilla Thellenberg, Johan Styrke, Hampus Nugin, Stefan
   Carlsson, David Robinson, Mats Anden, Jon Kindblom, Olof Stahl, Tomas
   Jiborn, Maria Nyberg, and Fredrik Sandin. This study was supported by
   the Swedish Research Council (2015-02332 and 2018-02825, to T. Stocks),
   the Swedish Cancer Society (CAN 2017/1019, to T. Stocks), and the Cancer
   Research Foundation at the Department of Oncology, Malmo University
   Hospital, Sweden (to T. Stocks)
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NR 44
TC 5
Z9 5
U1 0
U2 2
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 1055-9965
EI 1538-7755
J9 CANCER EPIDEM BIOMAR
JI Cancer Epidemiol. Biomarkers Prev.
PD JUL
PY 2022
VL 31
IS 7
BP 1483
EP 1491
DI 10.1158/1055-9965.EPI-22-0159
PG 9
WC Oncology; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Public, Environmental & Occupational Health
GA 2U7BJ
UT WOS:000823311200001
PM 35511742
OA Bronze
DA 2025-06-11
ER

PT J
AU Moosavian, SP
   Rahimlou, M
   Asbaghi, O
   Moradi, S
   Marx, W
   Paknahad, Z
AF Moosavian, Seyedeh Parisa
   Rahimlou, Mehran
   Asbaghi, Omid
   Moradi, Sajjad
   Marx, Wolfgang
   Paknahad, Zamzam
TI The effect of soy products on circulating adiponectin and leptin
   concentration in adults: A systematic review and meta-analysis of
   randomised controlled trials
SO INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
LA English
DT Review
ID HIGH-DOSE ISOFLAVONES; POSTMENOPAUSAL WOMEN; OXIDATIVE STRESS; PROTEIN
   SUPPLEMENTATION; MOLECULAR-MECHANISMS; INFLAMMATORY MARKERS; METABOLIC
   SYNDROME; ADIPOSE-TISSUE; SERUM LEPTIN; PPAR-GAMMA
AB Background Human clinical trials that have investigated the effect of soy product consumption on adipokines have reported inconsistent results. Our objective was to elucidate the role of soy product consumption on adiponectin and leptin in adults through a systematic review and meta-analysis of available randomised placebo-controlled trials (RCTs).
   Methods The systematic search included PubMed, Scopus, Web of Science, EmBase, Google Scholar and Cochrane database from inception to July 2020. Human clinical trials that reported the effect of soy product consumption on leptin and adiponectin were included. The pooled weighted mean difference (WMD) was calculated by the random-effects model. Heterogeneity, sensitivity analysis, and publication bias were reported using standard methods. Quality assessment was performed using Cochrane risk of bias assessment tool.
   Results Overall, 13 RCTs with 824 participants were included in this meta-analysis. Our analysis showed that soy product consumption did not significantly affect leptin (WMD: 0.01 ng/mL; 95% CI, -0.16, 0.18; P = .88) and adiponectin (WMD: -0.09 ng/mL; 95% CI, -0.29, 0.12; P = .39) concentration in comparison with control. Furthermore, subgroup analysis indicated that the effect remained non-significant when analysed by study design, participant demographics and intervention characteristics. Based on the Cochrane Collaboration Risk of Bias tool, seven studies were considered good quality and six studies were fair.
   Conclusion The present systematic review and meta-analysis suggest that soy product consumption had no significant effect on leptin and adiponectin levels in adults. However, future larger and well-designed trials are still needed to further explore this research area and to address the heterogeneous study design used in the existing literature.
C1 [Moosavian, Seyedeh Parisa; Paknahad, Zamzam] Isfahan Univ Med Sci, Sch Nutr & Food Sci, Dept Clin Nutr, POB 81745, Esfahan, Iran.
   [Rahimlou, Mehran] Zanjan Univ Med Sci, Sch Med, Dept Nutr, Zanjan, Iran.
   [Asbaghi, Omid] Lorestan Univ Med Sci, Student Res Comm, Khorramabad, Iran.
   [Moradi, Sajjad] FDA, Halal Res Ctr IRI, Tehran, Iran.
   [Moradi, Sajjad] Kermanshah Univ Med Sci, Sch Nutr Sci & Food Technol, Nutr Sci Dept, Kermanshah, Iran.
   [Marx, Wolfgang] Deakin Univ, IMPACT Inst Mental & Phys Hlth & Clin Translat, Food & Mood Ctr, Geelong, Vic, Australia.
C3 Isfahan University of Medical Sciences; Lorestan University of Medical
   Sciences; Kermanshah University of Medical Sciences; Deakin University
RP Paknahad, Z (corresponding author), Isfahan Univ Med Sci, Sch Nutr & Food Sci, Dept Clin Nutr, POB 81745, Esfahan, Iran.
EM paknahad@hlth.mui.ac.ir
RI paknahad, zamzam/E-6191-2012; Moosavian, Seyedeh/AAV-7757-2020; Moradi,
   Sajjad/AAX-7317-2020; Marx, Wolfgang/AFO-7355-2022; Rahimlou,
   Mehran/AAL-4902-2021
OI Moosavian, Seyedeh Parisa/0000-0002-5990-1984; paknahad,
   zamzam/0000-0002-1864-2576; Marx, Wolfgang/0000-0002-8556-8230;
   Rahimlou, Mehran/0000-0002-7861-8287
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NR 61
TC 3
Z9 3
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1368-5031
EI 1742-1241
J9 INT J CLIN PRACT
JI Int. J. Clin. Pract.
PD SEP
PY 2021
VL 75
IS 9
AR e14100
DI 10.1111/ijcp.14100
EA MAR 2021
PG 13
WC Medicine, General & Internal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Pharmacology & Pharmacy
GA TZ6OJ
UT WOS:000625319800001
PM 33619795
OA gold
DA 2025-06-11
ER

PT J
AU Gouws, C
   Mortazavi, R
   Mellor, D
   McKune, A
   Naumovski, N
AF Gouws, Caroline
   Mortazavi, Reza
   Mellor, Duane
   McKune, Andrew
   Naumovski, Nenad
TI The effects of Prickly Pear fruit and cladode (Opuntia spp.)
   consumption on blood lipids: A systematic review
SO COMPLEMENTARY THERAPIES IN MEDICINE
LA English
DT Review
DE Opuntia spp.; Prickly Pear; Cladode; Cactus; CVD; Lipids; Cholesterol;
   Triglyceride; Human; RCT
ID RISK-FACTORS; OXIDATIVE STRESS; FICUS-INDICA; CACTUS FIBER; PARAMETERS;
   GLUCOSE; ROBUSTA; NOPAL
AB Background: The current dietary recommendations for cardiovascular disease (CVD) risk reduction include increased fruit and vegetable consumption. The Opuntia spp., Prickly Pear (PP) fruit is rich in dietary fiber and may have lipid-lowering effects but it is often confused with the PP stem/leaf (Cladode (CLD)), or not identified. The efficacy of the PP fruit and CLD in reducing CVD risk is a growing area of research.
   Methods: This systematic review (PROSPERO: CRD42018110643), examined the effects of consuming the Opuntia spp. components (PP or CLD) on CVD risk factors, specifically total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and triglycerides (TG). The review, performed from February through September 2019, used resources available through Food Science and Technology Abstracts (EBSCO), Medline, Scopus, CINAHL, Web of Science and Cochrane databases.
   Results and Discussion: Eleven articles met the inclusion criteria, which characterised Opuntia spp. products as either PP (n= 6), CLD (n= 4) or commercial products' (n=1). Effects were investigated in healthy and obese populations as well as those with metabolic illnesses, specifically type 2 diabetes and metabolic syndrome. PP consumption was associated with significant reductions in TC (p < 0.05) in all but one included study, whereas in the remaining studies (n=6), LDL-C levels decreased (p < 0.05). Separately, the effect of CLD consumption on lipids was small with one study reporting a significant increase in plasma HDL-C in a subgroup of participants (> 45 years of age) following consumption of a patented CLD powder product. It is plausible, that differences in overall effect may be due to compositional distinctions between CLD and PP, such as fiber composition. Care must be taken in future studies to accurately report the identity of the selected components of Opuntia spp.
C1 [Gouws, Caroline; Mortazavi, Reza; McKune, Andrew; Naumovski, Nenad] Univ Canberra, Fac Hlth, Bldg 12, Canberra, ACT 2617, Australia.
   [Mellor, Duane] Aston Univ, Aston Med Sch, Birmingham B4 7ET, W Midlands, England.
   [McKune, Andrew] Univ Canberra, Res Inst Sport & Exercise, Canberra, ACT 2617, Australia.
   [McKune, Andrew] Univ KwaZulu Natal, Sch Hlth Sci Biokinet Exercise & Leisure Sci, ZA-4041 Durban, Kzn, South Africa.
C3 University of Canberra; University of Canberra; University of Kwazulu
   Natal
RP McKune, A (corresponding author), Univ Canberra, Fac Hlth, Bldg 12, Canberra, ACT 2617, Australia.
EM Andrew.Mckune@canberra.edu.au
RI McKune, Andrew/AAM-3086-2020; Naumovski, Nenad/O-5617-2015; Mortazavi,
   Reza/ABB-1748-2020; Mellor, Duane/H-1262-2012
OI Mellor, Duane/0000-0002-1369-3868; Mortazavi, Reza/0000-0001-8885-0891
FU Research Training Program Scholarship (RTP-S) by the Department of
   Education and Training of the Commonwealth Government, Australia
FX Ms Caroline Gouws is a recipient of the Research Training Program
   Scholarship (RTP-S), provided by the Department of Education and
   Training of the Commonwealth Government, Australia.
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NR 36
TC 19
Z9 19
U1 0
U2 17
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0965-2299
EI 1873-6963
J9 COMPLEMENT THER MED
JI Complement. Ther. Med.
PD MAY
PY 2020
VL 50
AR 102384
DI 10.1016/j.ctim.2020.102384
PG 10
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA LR4ZL
UT WOS:000535704900018
PM 32444049
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Abdel-Fattah, MM
   Messiha, BAS
   Mansour, AM
AF Abdel-Fattah, Maha Mohammed
   Messiha, Basim Anwar Shehata
   Mansour, Ahmed Mohamed
TI Modulation of brain ACE and ACE2 may be a promising protective strategy
   against cerebral ischemia/reperfusion injury: an experimental trial in
   rats
SO NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
LA English
DT Article
DE ACE; ACE2; Ischemia/reperfusion; Nimodipine; Telmisartan; Xanthenone
ID NECROSIS-FACTOR-ALPHA; ANGIOTENSIN RECEPTOR BLOCKERS; OXIDATIVE STRESS;
   ISCHEMIA-REPERFUSION; COGNITIVE IMPAIRMENT; DIMINAZENE ACETURATE;
   METABOLIC SYNDROME; RENIN-ANGIOTENSIN; ARTERY OCCLUSION; GAMMA
   ACTIVATION
AB The brain renin-angiotensin system (RAS) is considered a crucial regulator for physiological homeostasis and disease progression. We evaluated the protective effects of the angiotensin receptor blocker (ARB) telmisartan and the angiotensin-converting enzyme 2 (ACE2) activator xanthenone on experimental cerebral ischemia/reperfusion (I/R) injury. Rats were divided into a sham control, a cerebral I/R control, a standard treatment (nimodipine, 10 mg/kg/day, 15 days, p.o.), three telmisartan treatments (1, 3, and 10 mg/kg/day, 15 days, p.o.), and three xanthenone treatments (0.5, 1, and 2 mg/kg/day, 15 days, s.c.) groups. One hour after the last dose, all rats except the sham control group were exposed to 30-min cerebral ischemia followed by 24-h reperfusion. Brain ACE and ACE2 activities and the apoptotic marker caspase-3 levels were assessed. Glutathione (GSH), malondialdehyde (MDA), and nitric oxide end products (NOx) as oxidative markers and tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and IL-10 as immunological markers were assessed. Histopathological examination and immunohistochemical evaluation of glial fibrillary acidic protein (GFAP) were performed in cerebral cortex and hippocampus sections. Telmisartan and xanthenone in the higher doses restored MDA, NOx, TNF-alpha, IL-6, caspase-3, ACE, and GFAP back to normal levels and significantly increased GSH, IL-10, and ACE2 compared to I/R control values. Histopathologically, both agents showed mild degenerative changes and necrosis of neurons in cerebral cortex and hippocampus compared with I/R control group. Modulation of brain RAS, either through suppression of the classic ACE pathway or stimulation of its antagonist pathway ACE2, may be a promising strategy against cerebral I/R damage.
C1 [Abdel-Fattah, Maha Mohammed; Messiha, Basim Anwar Shehata] Beni Suef Univ, Fac Pharm, Dept Pharmacol & Toxicol, Bani Suwayf, Egypt.
   [Mansour, Ahmed Mohamed] Al Azhar Univ, Fac Pharm, Dept Pharmacol & Toxicol, Cairo, Egypt.
C3 Egyptian Knowledge Bank (EKB); Beni Suef University; Egyptian Knowledge
   Bank (EKB); Al Azhar University
RP Messiha, BAS (corresponding author), Beni Suef Univ, Fac Pharm, Dept Pharmacol & Toxicol, Bani Suwayf, Egypt.
EM drbasimanwar2006@yahoo.com
RI Abdel-Fattah, Maha/HHS-2044-2022
OI mohammed, maha/0000-0002-9019-8932; Messiha, Basim/0000-0002-5476-1409
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NR 96
TC 29
Z9 30
U1 0
U2 11
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0028-1298
EI 1432-1912
J9 N-S ARCH PHARMACOL
JI Naunyn-Schmiedebergs Arch. Pharmacol.
PD SEP
PY 2018
VL 391
IS 9
BP 1003
EP 1020
DI 10.1007/s00210-018-1523-3
PG 18
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA GP7SL
UT WOS:000441107600010
PM 29909460
DA 2025-06-11
ER

PT J
AU Lakhani, HV
   Sharma, D
   Dodrill, MW
   Nawab, A
   Sharma, N
   Cottrill, CL
   Shapiro, JI
   Sodhi, K
AF Lakhani, Hari Vishal
   Sharma, Dana
   Dodrill, Michael W.
   Nawab, Athar
   Sharma, Nitin
   Cottrill, Cameron Lee
   Shapiro, Joseph I.
   Sodhi, Komal
TI Phenotypic Alteration of Hepatocytes in Non-Alcoholic Fatty Liver
   Disease
SO INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
LA English
DT Review
DE Non-Alcoholic Fatty Liver Disease; Hepatocytes
ID IMPROVES INSULIN SENSITIVITY; INCREASES ADIPONECTIN LEVELS; INDUCED
   HEPATIC STEATOSIS; TUMOR-NECROSIS-FACTOR; RAT KUPFFER CELLS; VITAMIN-E;
   OXIDATIVE STRESS; NA/K-ATPASE; ADIPOSE-TISSUE; PPAR-GAMMA
AB Non-Alcoholic Fatty Liver Disease (NAFLD) has been recognized as the most common liver disorder in developed countries. NAFLD progresses from fat accumulation in hepatocytes to steatohepatitis to further stages of fibrosis and cirrhosis. Simple steatosis, i.e. fat deposition in the liver, is considered benign and gives way to non-alcoholic steatohepatitis (NASH) with a higher probability of progressing to cirrhosis, and liver-related mortality. Evidence has been found that this progression has been associated with marked alterations in hepatocyte histology and a shift in marker expression of healthy hepatocytes including increased expression of peroxisome proliferator-activated receptor gamma (PPAR gamma), adipocyte protein (aP2), CD36, interleukin-6 (IL-6), interleukin-18 (IL-18) and adiponectin. This progression shares much in common with the obesity phenotype, which involves a transformation of adipocytes from small, healthy cells to large, dysfunctional ones that contribute to redox imbalance and the progression of metabolic syndrome. Further, activation of Src/ERK signaling via the sodium potassium adenosine triphosphatase (Na/K-ATPase) alpha-1 subunit in impaired hepatocytes may contribute to redox imbalance, exacerbating the progression of NAFLD. This review hypothesizes that an adipogenic transformation of hepatocytes propagates redox imbalance and that the processes occurring in adipogenesis become activated in fat-laden hepatocytes in liver, thereby driving progression to NAFLD. Further, this review discusses therapeutic interventions to reverse NAFLD including the thiazolidinediones (TZDs) and a variety of antioxidant species. The peptide, pNaKtide, which is an antagonist of Na/K-ATPase signaling, is also proposed as a potential pharmacologic option for reducing reactive oxygen species (ROS) and reversing NAFLD by inhibiting the Na/K-ATPase-modulated ROS amplification loop.
C1 [Lakhani, Hari Vishal; Sharma, Dana; Dodrill, Michael W.; Nawab, Athar; Sharma, Nitin; Cottrill, Cameron Lee; Shapiro, Joseph I.] Marshall Univ, Joan C Edwards Sch Med, Dept Internal Med, Huntington, WV 25701 USA.
   [Sodhi, Komal] Marshall Univ, Joan C Edwards Sch Med, Dept Surg, Huntington, WV 25701 USA.
C3 Marshall University; Marshall University
RP Sodhi, K (corresponding author), Marshall Univ, Joan C Edwards Sch Med, Surg & Biomed Sci, Huntington, WV 25701 USA.
EM Sodhi@marshall.edu
FU National Institutes of Health [HL109015, HL105649, HL071556];
   Brickstreet Foundation
FX This work was supported by National Institutes of Health Grants to JIS
   (HL109015, HL105649 and HL071556), and by the Brickstreet Foundation
   (J.I.S.). Its contents are solely the responsibility of the authors and
   do not necessarily represent the official views of the National
   Institutes of Health.
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NR 91
TC 35
Z9 38
U1 0
U2 2
PU IVYSPRING INT PUBL
PI LAKE HAVEN
PA PO BOX 4546, LAKE HAVEN, NSW 2263, AUSTRALIA
SN 1449-1907
J9 INT J MED SCI
JI Int. J. Med. Sci.
PY 2018
VL 15
IS 14
BP 1591
EP 1599
DI 10.7150/ijms.27953
PG 9
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA HE3NT
UT WOS:000453263800002
PM 30588181
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Sharma, SS
   Jangale, NM
   Harsulkar, AM
   Gokhale, MK
   Joshi, BN
AF Sharma, Sona S.
   Jangale, Nivedita M.
   Harsulkar, Abhay M.
   Gokhale, Medha K.
   Joshi, Bimba N.
TI Chronic maternal calcium and 25-hydroxyvitamin D deficiency in Wistar
   rats programs abnormal hepatic gene expression leading to hepatic
   steatosis in female offspring
SO JOURNAL OF NUTRITIONAL BIOCHEMISTRY
LA English
DT Article
DE Wistar rats; Calcium; Vitamin D; Hepatic steatosis; Genes
ID VITAMIN-D DEFICIENCY; FATTY LIVER-DISEASE; METABOLIC SYNDROME;
   UNCOUPLING PROTEIN-2; DENSITY-LIPOPROTEIN; INSULIN-RESISTANCE; OXIDATIVE
   STRESS; BLOOD-PRESSURE; PREGNANCY; MICE
AB Importance of calcium and vitamin D deficiency is well established in adult dyslipidemia. We hypothesized that maternal calcium and vitamin D deficiency could alter offspring's lipid metabolism. Our objective was to investigate the effect of maternal dietary calcium and vitamin D deficiency on lipid metabolism and liver function of the F1 generation offspring. intergenerational calcium-deficient (CaD) and vitamin D-deficient (VDD) models were developed by mating normal male rats with deficient females and continuing maternal-deficient diets through pregnancy and lactation. Offspring were fed on control diet post-weaning and studied till 30 weeks. Lipid profile, serum glutamate pyruvate transaminase (SGPT), calcium and vitamin D levels were analyzed. Liver fat deposition, omega-3 fatty acids level and mRNA expression levels of peroxisome proliferator-activated receptor-alpha (PPAR-alpha), sterol regulatory element-binding protein 1c (SREBP-1c), interleukin 6 (IL-6), superoxide dismutase 1 (SOD-1) and uncoupling protein 2 (UCP2) were determined. Low serum vitamin D levels with an increase in SGPT and TG levels in CaD and VDD female offspring were observed. Severe liver steatosis with down-regulation of PPAR-alpha and UCP2 and up regulation of SREBP-1c, IL-6 and SOD-1 was observed in the female offspring born to deficient dams. CaD and VDD male offspring showed mild steatosis and down-regulation of UCP2 and SOD-1. We conclude that maternal calcium and vitamin D deficiency programs abnormal lipid metabolism and hepatic gene expression in the F1 generation female offspring leading to hepatic steatosis, despite feeding them on control diet post-weaning. (C) 2017 Elsevier Inc. All rights reserved.
C1 [Sharma, Sona S.; Gokhale, Medha K.; Joshi, Bimba N.] Agharkar Res Inst, Bioprospecting Grp, Pune 411004, Maharashtra, India.
   [Jangale, Nivedita M.; Harsulkar, Abhay M.] Bharati Vidyapeeth Deemed Univ, Poona Coll Pharm, Dept Pharmaceut Biotechnol, Pune 411038, Maharashtra, India.
C3 Department of Science & Technology (India); Agharkar Research Institute
   (ARI); Bharati Vidyapeeth Deemed University; Poona College of Pharmacy
RP Joshi, BN (corresponding author), Agharkar Res Inst, Bioprospecting Grp, Pune 411004, Maharashtra, India.
EM bnjoshiari@gmail.com
RI Harsulkar, Abhay/AAQ-3972-2020
FU Agharkar Research Institute, Pune, India [BIO24]
FX This study was supported by Agharkar Research Institute, Pune, India
   (BIO24).
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NR 69
TC 15
Z9 17
U1 0
U2 7
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0955-2863
EI 1873-4847
J9 J NUTR BIOCHEM
JI J. Nutr. Biochem.
PD MAY
PY 2017
VL 43
BP 36
EP 46
DI 10.1016/j.jnutbio.2017.01.008
PG 11
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA EU5DV
UT WOS:000401052700005
PM 28219837
DA 2025-06-11
ER

PT J
AU Dong, J
   Liang, YZ
   Zhang, J
   Wu, LJ
   Wang, S
   Hua, Q
   Yan, YX
AF Dong, Jing
   Liang, Ying-Zhi
   Zhang, Jie
   Wu, Li-Juan
   Wang, Shuo
   Hua, Qi
   Yan, Yu-Xiang
TI Potential Role of Lipometabolism-Related MicroRNAs in Peripheral Blood
   Mononuclear Cells as Biomarkers for Coronary Artery Disease
SO JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
LA English
DT Article
DE MicroRNA; Coronary artery disease; Lipometabolism; Mononuclear
   leucocytes; Biomarker
ID GENE-EXPRESSION; METABOLIC-SYNDROME; LIPID-METABOLISM; ATHEROSCLEROSIS;
   MIR-122; MIR-33; DIAGNOSIS; STRESS
AB Aim: To explore the relationship between lipometabolism-related microRNAs (miRNAs) in peripheral blood mononuclear cells (PBMCs) and the presence of coronary artery disease (CAD).
   Methods: In the present study, 161 stable CAD patients and 149 health controls were enrolled. The expression levels of seven miRNAs (miR-21, miR-24, miR-29a, miR-33a, miR-34a, miR-103a, and miR-122) in PBMCs were qualified by quantitative real-time polymerase chain reaction (qRT-PCR). The miRNA markers that showed significant difference between the two groups were used for further analysis. The risk of miRNA contributing to the presence of CAD was estimated by univariate and multivariate logistic regression models. The area under the receiver operating characteristic curve (AUC) was used to evaluate diagnostic accuracy.
   Results: The expression levels of miR-24, miR-33a, miR-103a, and miR-122 in PBMCs were significantly increased in CAD patients compared with controls and were significantly correlated with blood lipids in both CAD patients and controls. The increased levels of miR-24 (adjusted OR 1.32, 95% CI 1.07-1.62, P = 0.009), miR-33a (adjusted OR 1.57, 95% CI 1.35-1.81, P < 0.001), miR-103a (adjusted OR 1.01, 95% CI 1.01-1.02, P < 0.001), and miR-122 (adjusted OR 1.03, 95% CI 1.01-1.04, P < 0.001) were associated with risk of CAD. We identified a miRNA panel (miR-24, miR-33, miR-103a, and miR-122) that provided a high diagnostic accuracy of CAD (AUC = 0.911, 95% CI 0.880-0.942).
   Conclusion: The increased expression levels of miR-24, miR-33a, miR-103a, and miR-122 in PBMCs are associated with risk of CAD. A panel of the four miRNAs has considerable clinical value in diagnosing stable CAD.
C1 [Dong, Jing] Capital Med Univ, Xuanwu Hosp, Hlth Med Examinat Ctr, Beijing, Peoples R China.
   [Liang, Ying-Zhi; Zhang, Jie; Wu, Li-Juan; Wang, Shuo; Yan, Yu-Xiang] Capital Med Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, 10 Xitoutiao, Beijing 100069, Peoples R China.
   [Zhang, Jie; Wu, Li-Juan; Wang, Shuo; Yan, Yu-Xiang] Municipal Key Lab Clin Epidemiol, Beijing, Peoples R China.
   [Hua, Qi] Capital Med Univ, Xuanwu Hosp, Dept Cardiol, Beijing, Peoples R China.
C3 Capital Medical University; Capital Medical University; Capital Medical
   University
RP Yan, YX (corresponding author), Capital Med Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, 10 Xitoutiao, Beijing 100069, Peoples R China.
EM yanyxepi@ccmu.edu.cn
RI 周, 丽敏/JEO-3613-2023; Dong, Jing/KDM-6171-2024; wang, shuo/MIT-1662-2025
FU National Natural Science Foundation [81573214]; Beijing Municipal
   Natural Science Foundation [7162020]; Scientific Research Project of
   Beijing Municipal Educational Committee [KM201510025006]; National
   Science and Technology Support Program [2012BAI37B03]
FX This study was supported by the National Natural Science Foundation
   (81573214), the Beijing Municipal Natural Science Foundation (7162020),
   the Scientific Research Project of Beijing Municipal Educational
   Committee (KM201510025006), and the National Science and Technology
   Support Program(2012BAI37B03).
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Z9 35
U1 0
U2 5
PU JAPAN ATHEROSCLEROSIS SOC
PI TOKYO
PA NICHINAI-KAIKAN B1, 3-28-8 HONGO BUNKYO-KU, TOKYO, 113-0033, JAPAN
SN 1340-3478
EI 1880-3873
J9 J ATHEROSCLER THROMB
JI J. Atheroscler. Thromb.
PY 2017
VL 24
IS 4
BP 430
EP 441
DI 10.5551/jat.35923
PG 12
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA EW7EY
UT WOS:000402673800010
PM 27629254
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Noratto, G
   Martino, HSD
   Simbo, S
   Byrne, D
   Mertens-Talcott, SU
AF Noratto, Giuliana
   Martino, Hercia S. D.
   Simbo, Sunday
   Byrne, David
   Mertens-Talcott, Susanne U.
TI Consumption of polyphenol-rich peach and plum juice prevents risk
   factors for obesity-related metabolic disorders and cardiovascular
   disease in Zucker rats
SO JOURNAL OF NUTRITIONAL BIOCHEMISTRY
LA English
DT Article
DE Plum; Peach; Obesity; Metabolic syndrome; Cardiovascular risk;
   PPAR-gamma
ID MONOCYTE CHEMOATTRACTANT PROTEIN-1; ACTIVATED-RECEPTOR-GAMMA;
   DIET-INDUCED OBESITY; NF-KAPPA-B; INSULIN-RESISTANCE; OXIDATIVE STRESS;
   PPAR-GAMMA; ADIPOSE-TISSUE; ADHESION MOLECULES; PHENOLIC-COMPOUNDS
AB Polyphenols from fruits have been implied in the prevention of risk factors for cardiometabolic disorders and cardiovascular disease. The purpose of this study was to investigate if the consumption of peach and plum juice has a protective effect against obesity and metabolic disorders that promote the development of cardiovascular diseases. Obese Zucker and lean rats were fed with peach, plum juice ad libitum or placebo. Body weight gain, biochemical markers and molecular markers for inflammation and cardiovascular disease in heart tissue were quantified. Results show that peach and plum juice consumption protected against a combination of obesity-induced metabolic disorders including hyperglycemia, insulin and leptin resistance, dyslipidemia and low-density lipoprotein oxidation. This was accompanied by a decreased expression of pro-atherogenic and pro-inflammatory biomarkers in plasma and heart tissues including intercellular cell adhesion molecule-1, monocyte chemotactic protein-1, NF-kappa B and foam cell adherence to aortic arches. In addition, peach and plum juice consumption decreased the levels of angiotensin II in plasma and its receptor Agtr1 in heart tissues, suggesting a role of peach and plum polyphenols as peroxisome proliferator-activated receptor-gamma agonists. Furthermore, only plum juice significantly prevented body weight gain and increased the ratio high-density lipoprotein cholesterol/total cholesterol in plasma. This effect is most likely attributed to the plum's higher content of polyphenols (three times that of peach). Altogether, these results imply that cardioprotective effects can be achieved by replacing drinks high in sugar content with fruit juice rich in polyphenols in a diet. (C) 2015 Elsevier Inc. All rights reserved.
C1 [Noratto, Giuliana] Univ Idaho, Washington State Univ, Sch Food Sci, Pullman, WA USA.
   [Martino, Hercia S. D.] Univ Fed Vicosa, Dept Nutr & Hlth, Vicosa, MG, Brazil.
   [Simbo, Sunday] Texas A&M Univ, Dept Hlth & Kinesiol, College Stn, TX USA.
   [Byrne, David] Texas A&M Univ, Dept Hort Sci, College Stn, TX 77843 USA.
   [Noratto, Giuliana; Mertens-Talcott, Susanne U.] Texas A&M Univ, Dept Vet Physiol & Pharmacol, College Stn, TX 77843 USA.
   [Noratto, Giuliana; Mertens-Talcott, Susanne U.] Texas A&M Univ, Dept Nutr & Food Sci, College Stn, TX USA.
C3 University of Idaho; Washington State University; Universidade Federal
   de Vicosa; Texas A&M University System; Texas A&M University College
   Station; Texas A&M University System; Texas A&M University College
   Station; Texas A&M University System; Texas A&M University College
   Station; Texas A&M University System; Texas A&M University College
   Station
RP Noratto, G (corresponding author), FSHN Bldg 106, Pullman, WA 99164 USA.
EM giuliana.noratto@wsu.edu; smtalcott@tamu.edu
RI Noratto, Giuliana/AAS-8959-2020; Byrne, David/AAF-6262-2021
OI Stampini Duarte Martino, Hercia/0000-0002-8565-8439; Noratto,
   Giuliana/0000-0003-1831-7172; Mertens-Talcott,
   Susanne/0000-0003-2828-4044
FU Cooperative State Research, Education and Extension Service, US
   Department of Agriculture through the Vegetable and Fruit Improvement
   Center, Texas AgriLife Research [2006-34402-17121]
FX This study was partially supported by the Cooperative State Research,
   Education and Extension Service, US Department of Agriculture under
   Agreement 2006-34402-17121 (2006-2008) "Designing Foods for Health"
   through the Vegetable and Fruit Improvement Center, Texas AgriLife
   Research.
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NR 78
TC 59
Z9 70
U1 0
U2 57
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0955-2863
EI 1873-4847
J9 J NUTR BIOCHEM
JI J. Nutr. Biochem.
PD JUN
PY 2015
VL 26
IS 6
BP 633
EP 641
DI 10.1016/j.jnutbio.2014.12.014
PG 9
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA CI6ZM
UT WOS:000354912700007
PM 25801980
DA 2025-06-11
ER

PT J
AU Wang, X
   Zhang, DM
   Gu, TT
   Ding, XQ
   Fan, CY
   Zhu, Q
   Shi, YW
   Hong, Y
   Kong, LD
AF Wang, Xing
   Zhang, Dong-Mei
   Gu, Ting-Ting
   Ding, Xiao-Qin
   Fan, Chen-Yu
   Zhu, Qin
   Shi, Yun-Wei
   Hong, Ye
   Kong, Ling-Dong
TI Morin reduces hepatic inflammation-associated lipid accumulation in high
   fructose-fed rats via inhibiting sphingosine kinase 1/sphingosine
   1-phosphate signaling pathway
SO BIOCHEMICAL PHARMACOLOGY
LA English
DT Article
DE Morin; SphK1/S1P signaling pathway; NF-kappa B; Hepatic inflammation;
   Lipid accumulation
ID NF-KAPPA-B; FATTY LIVER; INSULIN-RESISTANCE; METABOLIC SYNDROME; DIETARY
   FRUCTOSE; STRESS-RESPONSE; BLOOD-PRESSURE; HUMAN ADIPOSE; PPAR-ALPHA;
   ACTIVATION
AB SphK1/S1P signaling pathway is involved in the development of hepatic inflammation and injury. But its role in high fructose-induced NAFLD has not yet been reported. The aim of this study was to elucidate the crucial role of SphK1/S1P signaling pathway in high fructose-induced hepatic inflammation and lipid accumulation in rats. Moreover, the hepatoprotective effects of morin, a flavonoid with antiinflammatory and anti-hyperlipedimic activities, on these hepatic changes in rats were investigated. High fructose-fed rats were orally treated with morin (30 and 60 mg/kg) and pioglitazone (4 mg/kg) for 8 weeks, respectively. Fructose feeding induced hyperlipidemia, and activated SphK1/S1P signaling pathway characterized by the elevation of SphK1 activity, SIP production as well as SphK1, S1PR1 and S1PR3 protein levels, which in turn caused NF-kappa B signaling activation to produce IL-1 beta, IL-6 and TNF-alpha and inflammation in the liver of rats. Subsequently, hepatic insulin and leptin signaling impairment and lipid metabolic disorder were observed in this animal model, resulting in liver lipid accumulation. Morin restored high fructose-induced the activation of hepatic SphK1/S1P signaling pathway in rats. Subsequently, the reduced NF-kappa B signaling activation by morin decreased inflammatory cytokine production, recovered insulin and leptin signaling impairment to reduce lipid accumulation and injury in the rat liver. These effects of morin were confirmed in Buffalo rat liver (BRL3A) cell model stimulated with 5 mM fructose. Thus, the inhibition of hepatic SphK1/S1P signaling pathway may be a novel mechanism by which morin exerts hepatoprotection in high fructose-fed rats, possibly involving liver inflammation inhibition and lipid accumulation recovery. (C) 2013 Elsevier Inc. All rights reserved.
C1 [Wang, Xing; Zhang, Dong-Mei; Gu, Ting-Ting; Ding, Xiao-Qin; Fan, Chen-Yu; Zhu, Qin; Shi, Yun-Wei; Hong, Ye; Kong, Ling-Dong] Nanjing Univ, State Key Lab Pharmaceut Biotechnol, Sch Life Sci, Nanjing 210008, Jiangsu, Peoples R China.
C3 Nanjing University
RP Kong, LD (corresponding author), Nanjing Univ, State Key Lab Pharmaceut Biotechnol, Sch Life Sci, Nanjing 210008, Jiangsu, Peoples R China.
EM kongld@nju.edu.cn
RI zhang, dongmei/B-8011-2013; shi, yunwei/S-3949-2016; Fan,
   Chenyu/KCY-8304-2024; Zhu, Qin/AAX-6363-2021; Hong, Ye/MIT-1879-2025
OI Zhu, Qin/0000-0001-5539-6071
FU Natural Science Foundation of China [81025025, J1103512]; National Basic
   Research Program of China 973 Program [2012CB517600, 2012CB517602];
   Ph.D. Programs Foundation of the Ministry of Education of China
   [20120091110039]; Program for Changjiang Scholars and Innovative
   Research Team in University [IRT1020]
FX Financial support for this work was provided by grants from the Natural
   Science Foundation of China (no. 81025025 and J1103512) and National
   Basic Research Program of China 973 Program No. 2012CB517600 (no.
   2012CB517602). Further supports were obtained from the Ph.D. Programs
   Foundation of the Ministry of Education of China (20120091110039), the
   Program for Changjiang Scholars and Innovative Research Team in
   University (IRT1020).
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NR 49
TC 71
Z9 75
U1 0
U2 36
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0006-2952
EI 1873-2968
J9 BIOCHEM PHARMACOL
JI Biochem. Pharmacol.
PD DEC 15
PY 2013
VL 86
IS 12
BP 1791
EP 1804
DI 10.1016/j.bcp.2013.10.005
PG 14
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 275XQ
UT WOS:000328713100016
PM 24134913
DA 2025-06-11
ER

PT J
AU Barsalani, R
   Riesco, E
   Lavoie, JM
   Dionne, IJ
AF Barsalani, R.
   Riesco, E.
   Lavoie, J-M.
   Dionne, I. J.
TI Effect of exercise training and isoflavones on hepatic steatosis in
   overweight postmenopausal women
SO CLIMACTERIC
LA English
DT Article
DE NON-ALCOHOLIC FATTY LIVER DISEASE; PHYTOESTROGENS; HEPATIC ENZYMES;
   ESTROGENS; MIXED EXERCISE TRAINING; MENOPAUSE
ID FATTY LIVER-DISEASE; GAMMA-GLUTAMYL-TRANSFERASE; METABOLIC SYNDROME;
   INSULIN SENSITIVITY; REPLACEMENT THERAPY; OXIDATIVE STRESS;
   CONTROLLED-TRIAL; RISK-FACTORS; WEIGHT-LOSS; RATS
AB Objectives Postmenopausal women are particularly inclined to an increased risk of developing non-alcoholic hepatic steatosis. The purpose of this study was to investigate whether adding isoflavone supplementation to exercise training could reduce the risk.
   Methods In a 6-month, double-blind, randomized, controlled trial, 54 healthy overweight-to-obese (body mass index 28-40 kg/m(2)) postmenopausal women were randomly assigned to one of the following groups: (1) exercise and isoflavones (Ex-Iso; n = 26), (2) exercise and placebo (Ex-Pla; n = 28). Exercise training consisted of three weekly sessions of mixed training. We examined the plasma level of specific hepatic enzymes (alanine aminotransferase, aspartate aminotransferase, gamma-glutamyltransferase, and alkaline phosphatase) as a reflection of fatty liver along with the calculation of the fatty liver index. All measures were obtained at baseline and after the 6-month intervention.
   Results Following the intervention, a lower fatty liver index (p < 0.01; 29% in Ex-Iso, 18% in Ex-Pla) and plasma gamma-glutamyltransferase (p < 0.01; 22% in Ex-Iso, 16% in Ex-Pla) were observed in both groups, with a higher reduction in the Ex-Iso group. On the other hand, for all other hepatic enzymes, there was no change.
   Conclusions Our results show that exercise training appears to bring favorable changes in the plasma level of hepatic enzymes, possibly due to the lowering of liver fat content. While postmenopausal women can benefit from this intervention to decrease the risk of developing non-alcoholic hepatic steatosis, it seems that the addition of isoflavones to exercise training provides some additional effects to those provided by exercise alone.
C1 [Barsalani, R.; Riesco, E.; Dionne, I. J.] Univ Sherbrooke, Fac Phys Educ & Sports, Sherbrooke, PQ J1K 2R1, Canada.
   [Dionne, I. J.] Univ Inst Geriatr Sherbrooke, Res Ctr Aging, CSSS IUGS, Social Serv & Hlth Ctr, Sherbrooke, PQ J1H 4C4, Canada.
   [Lavoie, J-M.] Univ Montreal, Dept Kinesiol, Montreal, PQ, Canada.
C3 University of Sherbrooke; University of Sherbrooke; Universite de
   Montreal
RP Dionne, IJ (corresponding author), Univ Inst Geriatr Sherbrooke, Res Ctr Aging, CSSS IUGS, Social Serv & Hlth Ctr, 1036 Belvedere S, Sherbrooke, PQ J1H 4C4, Canada.
OI Riesco, Eleonor/0000-0002-3664-6757
FU Canadian Institute of Health Research (CIHR)
FX This work was supported by grants from Canadian Institute of Health
   Research (CIHR).
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NR 50
TC 26
Z9 27
U1 0
U2 11
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 1369-7137
J9 CLIMACTERIC
JI Climacteric
PD FEB
PY 2013
VL 16
IS 1
BP 88
EP 95
DI 10.3109/13697137.2012.662251
PG 8
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA 072OI
UT WOS:000313681300013
PM 22530610
DA 2025-06-11
ER

PT J
AU Krskova, K
   Filipcik, P
   Zilka, N
   Olszanecki, R
   Korbut, R
   Gajdosechova, L
   Zorad, S
AF Krskova, K.
   Filipcik, P.
   Zilka, N.
   Olszanecki, R.
   Korbut, R.
   Gajdosechova, L.
   Zorad, S.
TI ANGIOTENSINOGEN AND ANGIOTENSIN-CONVERTING ENZYME MRNA DECREASE AND AT1
   RECEPTOR MRNA AND PROTEIN INCREASE IN EPIDIDYMAL FAT TISSUE ACCOMPANY
   AGE-INDUCED ELEVATION OF ADIPOSITY AND REDUCTIONS IN EXPRESSION OF GLUT4
   AND PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR (PPARγ)
SO JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
LA English
DT Article
DE adiposity; age; AT1 receptor; GLUT4; renin-angiotensin system;
   angiotensin-converting enzyme; peroxisome proliferator-activated
   receptor gamma
ID GLUTAMATE-INDUCED OBESITY; DIET-INDUCED OBESITY; MALE WISTAR RATS;
   GENE-EXPRESSION; HUMAN PREADIPOCYTES; METABOLIC SYNDROME; 3T3-L1
   ADIPOCYTES; OXIDATIVE STRESS; BLOOD-PRESSURE; SYSTEM GENES
AB Elevated adiposity is one of the accompanying features of increased age in humans and animals. Angiotensin II (Ang II) is considered as growth promoting peptide to be involved in hypertrophic enlargement of adipose tissue. However, systemic renin-angiotensin system (RAS) seems to decrease with increased age of rats. Local adipose tissue RAS might be independent of the systemic one. Therefore we performed a comprehensive study using rats with increased age from 9 to 26 weeks and evaluated angiotensinogen, angiotensin-converting enzyme (ACE) and AT(1) receptor mRNA in epididymal adipose tissue by RT-PCR. In addition, we determined AT(1) receptor protein by Western blotting and Ang II binding. These RAS parameters were correlated with expression of selected adiposity-dependent proteins such as leptin, adiponectin, insulin-dependent glucose transporter (GLUT4) and PPARgamma. Angiotensinogen and ACE expression decreased with increased age and adiposity. On the contrary, AT(1) receptor mRNA and protein was significantly elevated in 26-week-old rats though the Ang II binding was not different between 9 and 26-week-old animals. These results suggest dynamic adaptation of local adipose tissue RAS components to increased age and adiposity most likely by decreasing local Ang II formation which is thereafter compensated by increased expression of AT(1) receptor. However, this increase in AT(1) receptor mRNA and protein is not reflected in increased receptor binding. We believe that this complex regulation of adipose tissue RAS slows down the negative age and adiposity related changes in adipose tissue leptin, adiponectin, GLUT4 and PPARgamma.
C1 [Krskova, K.; Gajdosechova, L.; Zorad, S.] Slovak Acad Sci, Inst Expt Endocrinol, Bratislava 83306, Slovakia.
   [Filipcik, P.; Zilka, N.] Slovak Acad Sci, Inst Neuroimmunol, Bratislava 83306, Slovakia.
   [Olszanecki, R.; Korbut, R.] Jagiellonian Univ, Coll Med, Dept Pharmacol, Krakow, Poland.
C3 Slovak Academy of Sciences; Institute of Experimental Endocrinology,
   SAS; Slovak Academy of Sciences; Institute of Neuroimmunology, SAS;
   Jagiellonian University; Collegium Medicum Jagiellonian University
RP Zorad, S (corresponding author), Slovak Acad Sci, Inst Expt Endocrinol, 3 Vlarska St, Bratislava 83306, Slovakia.
EM stefan.zorad@savba.sk
RI Balazova, Lucia/Y-6371-2019; Filipcik, Peter/AGE-9297-2022; zilka,
   norbert/ABB-4545-2022; Zorad, Stefan/E-8740-2018
OI Korbut, Richard/0000-0002-3442-6435; Balazova,
   Lucia/0000-0001-6765-7486; Zorad, Stefan/0000-0003-2082-4659
FU VEGA [2/0089/11];  [APVV SK-PL-0066-09];  [803/N-Slovakia/2010/0]
FX This work was supported by grants of VEGA 2/0089/11 and cooperation
   grants: APVV SK-PL-0066-09, 803/N-Slovakia/2010/0.
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NR 64
TC 10
Z9 10
U1 0
U2 6
PU POLISH PHYSIOLOGICAL SOC
PI GRZEGORZECKA
PA JAGIELLONIAN UNIV SCHOOL MED, INST PHYSIOLOGY, 31-531 KRAKOW, 16
   GRZEGORZECKA, POLAND
SN 0867-5910
J9 J PHYSIOL PHARMACOL
JI J. Physiol. Pharmacol.
PD AUG
PY 2011
VL 62
IS 4
BP 403
EP 410
PG 8
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA 867XH
UT WOS:000298487600002
PM 22100841
DA 2025-06-11
ER

PT J
AU Sowers, JR
   Raij, L
   Jialal, I
   Egan, BM
   Ofili, EO
   Samuel, R
   Zappe, DH
   Purkayastha, D
   Deedwania, PC
AF Sowers, James R.
   Raij, Leopoldo
   Jialal, Ishwaral
   Egan, Brent M.
   Ofili, Elizabeth O.
   Samuel, Rita
   Zappe, Dion H.
   Purkayastha, Das
   Deedwania, Prakash C.
TI Angiotensin receptor blocker/diuretic combination preserves insulin
   responses in obese hypertensives
SO JOURNAL OF HYPERTENSION
LA English
DT Article
DE hydrochlorothiazide; hypertension; insulin secretion; metabolic
   syndrome; obesity; valsartan
ID GLUCOSE-TOLERANCE; OXIDATIVE STRESS; THERAPY; HYDROCHLOROTHIAZIDE;
   RESISTANCE; VALSARTAN; MODEL; ALDOSTERONE; SENSITIVITY; CANDESARTAN
AB Background Thiazide diuretics can impair glucose metabolism and increase new-onset diabetes. Adding an angiotensin receptor blocker to diuretics may protect against these metabolic effects; however, the mechanism of this protection is unclear.
   Method To explore potential mechanisms, a 16-week multicenter trial was conducted to ascertain the relative glucose metabolism effects of combined hydrochlorothiazide and angiotensin receptor blocker (valsartan) therapy compared with hydrochlorothiazide and calcium channel blocker (amlodipine) treatment in 412 centrally obese hypertensive individuals (BMI=35 +/- 7 kg/m(2), seated BP=159 +/- 8/94 +/- 8 mmHg, and mean age 56 years). Individuals were randomized to valsartan/hydrochlorothiazide, with force-titration to 320/25 mg or hydrochlorothiazide, with titration to hydrochlorothiazide 25 mg and amlodipine 10 mg, respectively. Changes from baseline to week 16 in fasting and 2-h postprandial glucose and insulin levels after an oral glucose load were measured.
   Results At week 16, clinic blood pressure reductions were similar (P>0.05) in both groups. Fasting and 2-h glucose levels increased (P<0.05) with the amlodipine combination but not with the valsartan combination. In concert with these glucose responses, postprandial insulin increases from baseline were substantially greater with valsartan than with amlodipine plus hydrochlorothiazide group (P=0.001). The glucose responses were inversely related to insulin responses at the study conclusion.
   Conclusion The novel observation of this investigation was that the combination of valsartan and hydrochlorothiazide was associated with greater glucose-stimulated insulin secretory and lesser glycemic excursion responses than the amlodipine combination group. Thus, this data suggests that adding an angiotensin receptor blocker attenuates the negative effects of thiazides on pancreatic beta-cell glucose-induced insulin secretion. J Hypertens 28: 1761-1769 (c) 2010 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
C1 [Sowers, James R.] Univ Missouri, Sch Med, Diabet & Cardiovasc Ctr, Columbia, MO 65212 USA.
   [Sowers, James R.] VA Med Ctr, Columbia, MO USA.
   [Raij, Leopoldo] Univ Miami, Miller Sch Med, Nephrol Hypertens Sect, Miami, FL 33136 USA.
   [Jialal, Ishwaral] UC Davis Med Ctr, Dept Pathol & Lab Med, Sacramento, CA USA.
   [Egan, Brent M.] Med Univ S Carolina, Div Gen Internal Med, Charleston, SC 29425 USA.
   [Ofili, Elizabeth O.] Morehouse Sch Med, Dept Med, Atlanta, GA 30310 USA.
   [Samuel, Rita; Zappe, Dion H.; Purkayastha, Das] Novartis Pharmaceut, E Hanover, NJ USA.
   [Deedwania, Prakash C.] Univ Calif San Francisco, Sch Med, Div Cardiol, San Francisco, CA 94143 USA.
C3 University of Missouri System; University of Missouri Columbia;
   University of Miami; University of California System; University of
   California Davis; Medical University of South Carolina; Morehouse School
   of Medicine; Novartis; Novartis USA; University of California System;
   University of California San Francisco
RP Sowers, JR (corresponding author), Univ Missouri, Diabet Cardiovasc Ctr, D109 Diabet Ctr UHC,1 Hosp Dr, Columbia, MO 65212 USA.
EM sowersj@health.missouri.edu
RI Jialal, Ishwarlal/AAG-6218-2019
FU Novartis Pharmaceuticals Corporation, East Hanover, New Jersey, USA;
   NIH; VA; University of Missouri
FX This study was funded by Novartis Pharmaceuticals Corporation, East
   Hanover, New Jersey, USA.J.R.S. has NIH and VA funding and has served as
   a consultant for Novartis Pharmaceuticals Corporation and Forest
   Pharmaceuticals. Research funding grants were provided to University of
   Missouri by Novartis Pharmaceuticals Corporation and Forest
   Pharmaceuticals.
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NR 29
TC 34
Z9 35
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0263-6352
EI 1473-5598
J9 J HYPERTENS
JI J. Hypertens.
PD AUG
PY 2010
VL 28
IS 8
BP 1761
EP 1769
DI 10.1097/HJH.0b013e32833af380
PG 9
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 628JJ
UT WOS:000280115300023
PM 20498618
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Andersson, A
   Tengblad, S
   Karlström, B
   Kamal-Eldin, A
   Landberg, R
   Basu, S
   Åman, P
   Vessby, B
AF Andersson, Agneta
   Tengblad, Siv
   Karlstrom, Brita
   Kamal-Eldin, Afaf
   Landberg, Rikard
   Basu, Samar
   Aman, Per
   Vessby, Bengt
TI Whole-grain foods do not affect insulin sensitivity or markers of lipid
   peroxidation and inflammation in healthy, moderately overweight subjects
SO JOURNAL OF NUTRITION
LA English
DT Article
ID CORONARY-HEART-DISEASE; C-REACTIVE PROTEIN; PLASMINOGEN-ACTIVATOR
   INHIBITOR; TOTAL DIETARY FIBER; DIABETES-MELLITUS; GLYCEMIC LOAD;
   CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; OXIDATIVE STRESS;
   ARTERY-DISEASE
AB High intakes of whole grain foods are inversely related to the incidence of coronary heart diseases and type 2 diabetes, but the mechanisms remain unclear. Our study aimed to evaluate the effects of a diet rich in whole grains compared with a diet containing the same amount of refined grains on insulin sensitivity and markers of lipid peroxidation and inflammation. In a randomized crossover study, 22 women and 8 men (BMI 28 +/- 2) were given either whole-grain or refined-grain products (3 bread slices, 2 crisp bread slices, 1 portion muesli, and 1 portion pasta) to include in their habitual daily diet for two 6-wk periods. Peripheral insulin sensitivity was determined by euglycemic hyperinsulinemic clamp tests. 8-Iso-prostaglandin F-2 alpha (8-iso PGF(2 alpha)), an F-2-isoprostane, was measured in the urine as a marker of lipid peroxidation, and highly sensitive C-reactive protein and IL-6 were analyzed in plasma as markers of inflammation. Peripheral insulin sensitivity [mg glucose center dot kg body wt(-1) center dot min(-1) per unit plasma insulin (mU/L) x 100] did not improve when subjects consumed whole-grain products (6.8 +/- 3.0 at baseline and 6.5 +/- 2.7 after 6 wk) or refined products (6.4 +/- 2.9 and 6.9 +/- 3.2, respectively) and there were no differences between the 2 periods. Whole-grain consumption also did not affect 8-iso-PGF(2 alpha) in urine, IL-6 and C-reactive protein in plasma, blood pressure, or serum lipid concentrations. In conclusion, substitution of whole grains (mainly based on milled wheat) for refined-grain products in the habitual daily diet of healthy moderately overweight adults for 6-wk did not affect insulin sensitivity or markers of lipid peroxidation and inflammation.
C1 Uppsala Univ, Dept Publ Hlth & Caring Sci, S-75185 Uppsala, Sweden.
   Swedish Univ Agr Sci, Dept Food Sci, S-75007 Uppsala, Sweden.
C3 Uppsala University; Swedish University of Agricultural Sciences
RP Andersson, A (corresponding author), Uppsala Univ, Dept Publ Hlth & Caring Sci, S-75185 Uppsala, Sweden.
EM agneta.andersson@pubcare.uu.se
OI Kamal-Eldin, Afaf/0000-0002-5187-3317
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NR 51
TC 174
Z9 203
U1 0
U2 57
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0022-3166
EI 1541-6100
J9 J NUTR
JI J. Nutr.
PD JUN
PY 2007
VL 137
IS 6
BP 1401
EP 1407
DI 10.1093/jn/137.6.1401
PG 7
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 173MU
UT WOS:000246878000009
PM 17513398
OA Bronze
DA 2025-06-11
ER

PT J
AU Peschel, T
   Sixt, S
   Beitz, F
   Sonnabend, M
   Muth, G
   Thiele, H
   Tarnok, A
   Schuler, G
   Niebauer, J
AF Peschel, Thomas
   Sixt, Sebastian
   Beitz, Frido
   Sonnabend, Melanie
   Muth, Gerhard
   Thiele, Holger
   Tarnok, Attila
   Schuler, Gerhard
   Niebauer, Josef
TI High, but not moderate frequency and duration of exercise training
   induces downregulation of the expression of inflammatory and atherogenic
   adhesion molecules
SO EUROPEAN JOURNAL OF CARDIOVASCULAR PREVENTION & REHABILITATION
LA English
DT Article
DE adhesion molecules; coronary artery disease; diabetes mellitus type 2;
   exercise training
ID CORONARY-ARTERY-DISEASE; LIFE-STYLE CHANGES; METABOLIC SYNDROME;
   HEART-DISEASE; RISK-FACTORS; CARDIOVASCULAR-DISEASE; PHYSICAL EXERCISE;
   OXIDATIVE STRESS; PART I; INTERVENTION
AB Background Lifestyle changes which include daily exercise training have been shown to slow the progression of coronary artery disease. We designed a study to examine the effects of a multifactorial intervention on atherogenic adhesion molecules on the surface of monocytes in patients with coronary artery disease.
   Methods We randomized 39 patients with coronary artery disease to (i) an intervention program which consisted of 4 weeks of daily 6 x 15 min ergometer training at submaximal intensity in addition to a 1 h/week group exercise session, followed by 5 months of home-based ergometer training of 30 min/day again in addition to a 1 h/week group exercise session or 00 conventional therapy. All patients received a statin. Monocyte-bound cellular adhesion molecules LFA-1 (CD11a), MAC-1 (CD11b), VLA-4 (CD49d) and L-selectin (CD62L) were assessed by fluorescence activated cell sorting analysis.
   Results After 4 weeks the multifactorial intervention led to a significant improvement of maximal work capacity, lipid profile, body mass index, blood pressure, fasting glucose and hemoglobin Alc. This was associated with a reduced expression of MAC-1 and VLA-4. After 5 months of a home-based intervention the beneficial effects of the cardiovascular risk profile were still apparent, whereas the effects on the expression of adhesion molecules were blunted.
   Conclusion In patients treated with statins, 4 weeks of high frequency and long duration exercise training led to a diminished expression of atherogenic adhesion molecules MAC-1 und VLA-4. After 5 months of home-based exercise training of moderate frequency and duration, these effects were blunted. Our data suggest that our patients in cardiac rehabilitation programs might further benefit from the antiatherogenic effects of an even higher amount of exercise training.
C1 Paracelsus Med Univ, Inst Sports Med Prevent & Rehabil, A-5020 Salzburg, Austria.
   Univ Leipzig, Ctr Heart, Dept Internal Med Cardiol, Salzburg, Austria.
   Univ Leipzig, Ctr Heart, Dept Pediat Cardiol, Salzburg, Austria.
C3 Paracelsus Private Medical University
RP Niebauer, J (corresponding author), Paracelsus Med Univ, Inst Sports Med Prevent & Rehabil, Lindhof Str 20, A-5020 Salzburg, Austria.
EM j.niebauer@salk.at
RI Thiele, Holger/ABE-6792-2020
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NR 30
TC 21
Z9 23
U1 0
U2 8
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1741-8267
EI 1741-8275
J9 EUR J CARDIOV PREV R
JI Eur. J. Cardiovasc. Prev. Rehabil.
PD JUN
PY 2007
VL 14
IS 3
BP 476
EP 482
DI 10.1097/HJR.0b013e328167239d
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 187BK
UT WOS:000247822100021
PM 17568252
DA 2025-06-11
ER

PT J
AU Dobrian, AD
AF Dobrian, Anca Dana
TI The complex role of PPARγ in renal dysfunction in obesity:: Managing a
   Janus-faced receptor
SO VASCULAR PHARMACOLOGY
LA English
DT Review
DE PPARs; blood pressure; natriuresis; collecting ducts; proximal tubule;
   sodium transporters; glomerulosclerosis; tubulointerstitial fibrosis
ID LOWERS BLOOD-PRESSURE; DOMINANT-NEGATIVE MUTATIONS;
   CONGESTIVE-HEART-FAILURE; NITRIC-OXIDE SYNTHESIS; NECROSIS-FACTOR-ALPHA;
   THICK ASCENDING LIMB; II TYPE-1 RECEPTOR; OXIDATIVE STRESS; RAT MODEL;
   INSULIN SENSITIVITY
AB Obesity is frequently accompanied by insulin resistance, type II diabetes, hypertension and atherosclerosis, a cluster of pathologies that are the major components of the metabolic syndrome. Obesity is a known cause for renal dysfunction that leads to two major renal pathologies: hypertension and glomerular and tubulointerstitial injury. Peroxizome proliferator activated receptors (PPARs) are transcription factors belonging to the nuclear hormone receptor superfamily with important functions in the regulation of metabolism. The role of PPAR gamma isoforms in adipogenesis and vascular inflammation associated to obesity has been vastly studied and is well recognized, albeit not completely mechanistically understood. Also, the effect of various PPAR gamma agonists on blood pressure reduction in different forms of hypertension, including obesity related hypertension has been reported, but the mechanisms involved are only beginning to be studied. Even less clear is the concurrent beneficial effect of PPAR gamma agonists thiazolmendiones (TZD) on blood pressure reduction in different forms of hypertension and, at the same time, in some cases, the significant water retention leading to edema and heart failure. The occurrence of both these apparently opposite effects on the renal water and sodium handling suggests a complex role of PPAR gamma in the kidney that is likely related to the metabolic state. Also, PPAR gamma activation leads to a reduction in mesangial cell proliferation while stimulating apoptosis. TZD treatment reduces albuminuria in obese and diabetic humans and rodent models suggesting protective effects against renal tubuloglomerular injury. The focus of this review is to present and critically discuss the recent findings on the roles of PPAR gamma in the kidney in direct relation to renal function and renal injury in obesity and obesity-initiated diabetes. (c) 2006 Elsevier Inc. All rights reserved.
C1 Eastern Virginia Med Sch, Dept Physiol Sci, Norfolk, VA 23507 USA.
C3 Eastern Virginia Medical School
RP Dobrian, AD (corresponding author), Eastern Virginia Med Sch, Dept Physiol Sci, 700W Olney Rd,Lewis Hall,Room 2027, Norfolk, VA 23507 USA.
EM dobriaad@evms.edu
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PU ELSEVIER SCIENCE INC
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J9 VASC PHARMACOL
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DI 10.1016/j.vph.2006.01.017
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WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 064ZZ
UT WOS:000239130500005
PM 16716756
DA 2025-06-11
ER

PT J
AU Beegum, PPS
   Ramesh, SV
   Pandiselvam, R
   Neema, M
   Daliyamol
   Manikantan, MR
   Hebbar, KB
AF Beegum, P. P. Shameena
   Ramesh, S. V.
   Pandiselvam, Ravi
   Neema, M.
   Daliyamol
   Manikantan, M. R.
   Hebbar, K. B.
TI Perspectives on the cardioprotective, neuroprotective and anti-obesity
   functions of coconut (Cocos nucifera L.)
SO FOOD BIOSCIENCE
LA English
DT Article
DE Coconut derivatives; Virgin coconut oil; Medium chain fatty acids;
   Lauric acid; Heart health; Obesity; Functional foods
ID CORONARY-HEART-DISEASE; PRECURSOR PROTEIN APP; OIL-ENRICHED DIET;
   ALZHEIMERS-DISEASE; AMYLOID-BETA; MEDIUM-CHAIN; METABOLIC SYNDROME;
   OXIDATIVE STRESS; VIRGIN; FAT
AB Widely acclaimed as the "tree of life," the coconut is intrinsically woven into human culture as a source of food, shelter, and medicine. Coconut oil and its derivatives have found diverse applications in both food and industry. Of late, the consumption of coconut in the form of oil and its derivatives has been proven to be beneficial. Taking into account the most recent clinical evidences, an attempt was made to present a concise review of the cardioprotective, neuroprotective, and anti -obesity effects of coconut and its derivatives. Our analysis reveals that research evidence supports the cardioprotective and neuroprotective effects of coconut. Numerous clinical trials have proven the anti -obesity and hypoglycemic effects of coconut oil and products. High contents of myocardial anti -oxidants, and differential metabolism of medium chain fatty acids (MCFAs) provide cardioprotective effects. The ketogenic effect of coconut derived products confers neuroprotective measures and enhanced energy expenditure in the metabolism of MCFAs and polyphenolic anti -oxidants are suggested to offer anti -obesity effects. Nevertheless, further research with more randomized, controlled, large clinical trials that evaluate the optimal dosage and side effects, if any, are warranted. Based on this comprehensive review, it is understood that MCFAs are the key component, apart from the phytochemicals such as polyphenols, tocopherols, and other antioxidants that accord these health benefits. Overall, the health benefits of coconut and its derivatives are perceptible, though there is a need for long-term clinical trials. Also a shift of research focus from coconut fatty acids and oil to other phytochemicals and to design appropriate clinical and epidemiological studies to discover coconut biomolecules of health importance is warranted.
C1 [Beegum, P. P. Shameena; Ramesh, S. V.; Pandiselvam, Ravi; Manikantan, M. R.; Hebbar, K. B.] ICAR Cent Plantat Crops Res Inst, Physiol Biochem & Post Harvest Technol, Kasaragod 671124, Kerala, India.
   [Neema, M.] ICAR Indian Inst Oil Palm Res RC Palode, Crop Improvement, Palode 695562, Kerala, India.
   [Daliyamol] ICAR Cent Plantat Crops Res Inst, Crop Protect, Kasaragod 671124, Kerala, India.
C3 Indian Council of Agricultural Research (ICAR); ICAR - Central
   Plantation Crops Research Institute; Indian Council of Agricultural
   Research (ICAR); ICAR - Central Plantation Crops Research Institute
RP Beegum, PPS; Ramesh, SV; Pandiselvam, R (corresponding author), ICAR Cent Plantat Crops Res Inst, Physiol Biochem & Post Harvest Technol, Kasaragod 671124, Kerala, India.
EM shameena.beegum@icar.gov.in; ramesh.sv@icar.gov.in;
   r.pandiselvam@icar.gov.in
RI Pandiselvam, R./I-5229-2019; beegum, shameena/LDE-9123-2024; Manikantan,
   M.R./AAT-4298-2021
OI Ramesh, S.V./0000-0002-2107-360X
FU Indian Council of Agricultural Research-Central Plantation Crops
   Research Institute (ICAR-CPCRI)
FX <B>Funding</B> Authors would like to thank Indian Council of
   Agricultural Research-Central Plantation Crops Research Institute
   (ICAR-CPCRI) for funding this research.
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NR 110
TC 5
Z9 5
U1 1
U2 7
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2212-4292
EI 2212-4306
J9 FOOD BIOSCI
JI Food Biosci.
PD APR
PY 2024
VL 58
AR 103756
DI 10.1016/j.fbio.2024.103756
EA FEB 2024
PG 18
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA MR8T3
UT WOS:001195458900001
DA 2025-06-11
ER

PT J
AU Sun, LS
   Zhang, XR
   Yang, J
   Yuan, J
   Lei, XX
AF Sun, Lisha
   Zhang, Xiaoran
   Yang, Jiao
   Yuan, Jun
   Lei, Xingxing
TI Lower Visceral Fat is Related to Diabetic Peripheral Neuropathy
SO DIABETES METABOLIC SYNDROME AND OBESITY
LA English
DT Article
DE type 2 diabetes; visceral fat; peripheral neuropathy; correlation;
   metabolic complications
AB Objective: Visceral fat area (VFA) levels have been found to exhibit a strong association with various conditions such as insulin resistance (IR), inflammation, oxidative stress, metabolic syndrome (MetS), hyperlipidemia, diabetes, and its vascular complications. These complications include hypertension, cardiovascular disease, diabetic retinopathy (DR), albuminuria, and cardiovascular autonomic dysfunction, which is considered one of the main types of diabetic neuropathy. This study aimed to investigate the correlation between visceral fat and peripheral neuropathy in patients with type 2 diabetes (T2DM). Methods: A retrospective analysis of clinical data of patients diagnosed with type 2 diabetes admitted to our hospital was conducted. After excluding 28 cases, a total of 488 patients were included, divided into the group with peripheral neuropathy (207 cases) and the control group without peripheral neuropathy (281 cases). The correlation between VFA and the presence of DPN was assessed using correlation and multiple logistic regression analyses. Results: In terms of general information, the group with peripheral neuropathy had lower BMI but longer duration of diabetes compared to the control group. Regarding biochemical indicators, VFA were lower in the group with peripheral neuropathy, while FPG and HbA1c levels were higher (all P<0.05). Spearman correlation analysis showed a negative correlation between VFA, and the presence of peripheral neuropathy in patients with type 2 diabetes (P<0.05). Logistic regression analysis indicated that VFA, duration of diabetes, and HbA1c level were influencing factors for the occurrence of peripheral neuropathy in patients with type 2 diabetes (P<0.05). Conclusion: This study revealed a correlation between visceral fat and peripheral neuropathy in patients with type 2 diabetes, highlighting the importance of monitoring visceral fat in such patients. In addition to lower levels of VFA, factors such as duration of diabetes and glycated hemoglobin (HbA1c) level were also associated with peripheral neuropathy in patients with T2DM.
C1 [Sun, Lisha; Zhang, Xiaoran; Yang, Jiao; Lei, Xingxing] Hosp Chengdu Univ Tradit Chinese Med, Dept Endocrinol, Chengdu, Sichuan, Peoples R China.
   [Yuan, Jun] Chengdu Univ Tradit Chinese Med, Chengdu, Sichuan, Peoples R China.
C3 Chengdu University of Traditional Chinese Medicine; Chengdu University
   of Traditional Chinese Medicine
RP Lei, XX (corresponding author), Hosp Chengdu Univ Tradit Chinese Med, Dept Endocrinol, Chengdu, Sichuan, Peoples R China.
EM iopmj38169@tom.com
RI Sun, Lisha/AAS-5688-2021; Zhang, Xiaoran/AAJ-6366-2021
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NR 21
TC 1
Z9 1
U1 2
U2 5
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-7007
J9 DIABET METAB SYND OB
JI Diabetes Metab. Syndr. Obes.
PY 2024
VL 17
BP 2967
EP 2974
DI 10.2147/DMSO.S471715
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA C3Z7I
UT WOS:001288782700001
PM 39139742
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Moreira, ALG
   Silva, GA
   Silva, PHF
   Salvador, SL
   Vicente, RM
   Ferreira, GC
   Tanus-Santos, JE
   Mayer, MPA
   Ishikawa, KH
   de Souza, SLS
   Furlaneto, FAC
   Messora, MR
AF Moreira, Andre L. G.
   Silva, Giselle A.
   Silva, Pedro H. F.
   Salvador, Sergio L.
   Vicente, Raphael M.
   Ferreira, Graziele C.
   Tanus-Santos, Jose E.
   Mayer, Marcia P. A.
   Ishikawa, Karin H.
   de Souza, Sergio Luis Scombatti
   Furlaneto, Flavia A. C.
   Messora, Michel R.
TI Bifidobacterium animalis subspecies lactis HN019 can
   reduce the sequelae of experimental periodontitis in rats modulating
   intestinal parameters, expression of lipogenic genes, and levels of
   hepatic steatosis
SO JOURNAL OF PERIODONTAL RESEARCH
LA English
DT Article
DE Bifidobacterium lactis; periodontitis; probiotics
ID TYPE-2 DIABETES-MELLITUS; LIGATURE-INDUCED PERIODONTITIS; FATTY
   LIVER-DISEASE; METABOLIC SYNDROME; GUT MICROBIOTA; SYNBIOTIC
   SUPPLEMENTATION; PROBIOTIC SUPPLEMENTATION; INSULIN SENSITIVITY;
   OXIDATIVE STRESS; ADIPOSE-TISSUE
AB ObjectiveTo determine whether Bifidobacterium animalis subspecies lactis HN019 (B. lactis HN019) can reduce the sequelae of experimental periodontitis (EP) in rats modulating systemic parameters. BackgroundThis study evaluated the effects of probiotic therapy (PROB) in the prevention of local and systemic damage resulting from EP. MethodsForty-eight rats were allocated into four groups: C (control), PROB, EP, and EP-PROB. PROB (1 x 10(10) CFU/mL) administration lasted 8 weeks and PE was induced on the 7th week by placing ligature on the animals' lower first molars. All animals were euthanized in the 9th week of the experiment. Biomolecular analyses, RT-PCR, and histomorphometric analyses were performed. The data obtained were analyzed statistically (ANOVA, Tukey, p < .05). ResultsThe EP group had higher dyslipidemia when compared to the C group, as well as higher levels of insulin resistance, proteinuria levels, percentages of systolic blood pressure, percentage of fatty hepatocytes in the liver, and expression of adipokines was up-regulated (LEPR, NAMPT, and FABP4). All these parameters (except insulin resistance, systolic blood pressure, LEPR and FABP4 gene expression) were reduced in the EP-PROB group when compared to the EP group. The EP group had lower villus height and crypt depth, as well as a greater reduction in Bacteroidetes and a greater increase in Firmicutes when compared to the EP-PROB group. Greater alveolar bone loss was observed in the EP group when compared to the EP-PROB group. ConclusionBifidobacterium lactis HN019 can reduce the sequelae of EP in rats modulating intestinal parameters, attenuating expression of lipogenic genes and hepatic steatosis.
C1 [Moreira, Andre L. G.; Silva, Giselle A.; Silva, Pedro H. F.; Vicente, Raphael M.; de Souza, Sergio Luis Scombatti; Furlaneto, Flavia A. C.; Messora, Michel R.] Univ Sao Paulo, Sch Dent Ribeirao Preto, Dept Oral & Maxillofacial Surg & Periodontol, Ribeirao Preto, SP, Brazil.
   [Salvador, Sergio L.] Univ Sao Paulo, Sch Pharmaceut Sci Ribeirao Preto, Dept Clin Anal, Ribeirao Preto, SP, Brazil.
   [Ferreira, Graziele C.; Tanus-Santos, Jose E.] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Pharmacol, Ribeirao Preto, SP, Brazil.
   [Mayer, Marcia P. A.; Ishikawa, Karin H.] Univ Sao Paulo, Inst Biomed Sci, Dept Microbiol, Sao Paulo, Brazil.
   [Furlaneto, Flavia A. C.] Av Cafe s-n, BR-14020150 Ribeirao Preto, SP, Brazil.
C3 Universidade de Sao Paulo; Universidade de Sao Paulo; Universidade de
   Sao Paulo; Universidade de Sao Paulo; Institute Biomed Science,
   University Sao Paulo
RP Furlaneto, FAC (corresponding author), Av Cafe s-n, BR-14020150 Ribeirao Preto, SP, Brazil.
EM flafurlaneto@usp.br
RI de Souza, Sergio/F-8803-2014; Furlaneto, Flavia/C-4171-2013; Ferreira,
   Graziele/D-9011-2018; Messora, Michel/F-3480-2012; Salvador,
   Sergio/G-1015-2019; Mayer, Marcia/D-4645-2012; Felix Silva, Pedro
   Henrique/S-2286-2019
OI Mayer, Marcia/0000-0002-5910-8433; Felix Silva, Pedro
   Henrique/0000-0002-7583-7046; Salvador, Sergio Luiz/0000-0002-4867-7294;
   Martini Vicente, Raphael/0000-0001-6454-8014; ISHIKAWA,
   KARIN/0000-0003-3926-3572
FU Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior; Fundacao de
   Amparo a Pesquisa do Estado de Sao Paulo; Sao Paulo Research Foundation
   (FAPESP) [2017/26257-9, 2018/16009-0]
FX Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior; Fundacao de
   Amparo a Pesquisa do Estado de Sao PauloThe study was supported by the
   Sao Paulo Research Foundation (FAPESP - Funding 2017/26257-9 and
   2018/16009-0).
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NR 108
TC 3
Z9 3
U1 2
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-3484
EI 1600-0765
J9 J PERIODONTAL RES
JI J. Periodont. Res.
PD OCT
PY 2023
VL 58
IS 5
BP 1006
EP 1019
DI 10.1111/jre.13163
EA JUL 2023
PG 14
WC Dentistry, Oral Surgery & Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dentistry, Oral Surgery & Medicine
GA R4GJ7
UT WOS:001033702400001
PM 37482954
DA 2025-06-11
ER

PT J
AU Tanaka, Y
   Xiao, L
   Miwa, N
AF Tanaka, Yoshiharu
   Xiao, Li
   Miwa, Nobuhiko
TI Hydrogen-rich bath with nano-sized bubbles improves antioxidant capacity
   based on oxygen radical absorbing and inflammation levels in human serum
SO MEDICAL GAS RESEARCH
LA English
DT Article
DE anti-inflammatory effect; antioxidant capacity; C-reactive protein;
   electrolysis; human serum; human skin; hydrogen-rich water; nano-bubble
ID C-REACTIVE PROTEIN; OXIDATIVE STRESS; CARDIOVASCULAR-DISEASE; METABOLIC
   SYNDROME; WATER; METAANALYSIS; MORTALITY
AB This study compared the effects of hydrogen-water (HW) bath on the oxygen radical absorption-based antioxidant capacity and the inflammatory indicator, C-reactive protein (CRP), in serum between healthy volunteers and inflammatory/collagen disease-patients. The HW bath apparatus supplied nano-bubbles with a diameter of 110 +/- 10 nm and 338-682 mu g/L of dissolved hydrogen after 120 minutes electrolysis, and nano-bubbles increased to 9.91 x 107/mL along with the increase of correlative dissolved hydrogen. Ten-minute HW bath increased the oxygen radical absorption-based antioxidant capacity to 110.9 +/- 9.2% at post-bathing 120 minutes, although unaltered with 10-minute normal water bath at 40 degrees C in healthy subjects. The CRP level was repressed to 70.2 +/- 12.1% at 120 minutes after HW bath, although rather increased for normal water bath. In the patients with connective tissue diseases, the CRP level was repressed to 3-24% upon 9 days to 4 months of HW bathing. In another six patients with diverse autoimmune-related diseases, upon daily HW bathing as long as 2-25 months, the pre-bathing CRP level of 5.31 mg/dL decreased to 0.24 mg/dL being within the standard-range, with relief of visible inflammatory symptoms for some cases. Thus, the HW bath with high-density nano-bubbles has beneficial effects on serum antioxidant capacity, inflammation, and the skin appearance. The study was approved by the Committee of Ethics, Japanese Center of Anti-Aging Medical Sciences (Authorization No. H-15-03-2, on January 15, 2019), which was a non-profitable organization officially authenticated by the Hiroshima Prefecture Government of Japan.
C1 [Tanaka, Yoshiharu] Osaka Prefecture Univ, Fac Liberal Arts & Sci, Div Biol, Osaka, Japan.
   [Tanaka, Yoshiharu] Osaka Prefecture Univ, Fac Technol, Div Quantum Radiat, Osaka, Japan.
   [Xiao, Li] Nippon Dent Univ Tokyo, Sch Life Dent Tokyo, Dept Pharmacol, Tokyo, Japan.
   [Miwa, Nobuhiko] Inc Assoc Inst Hydrogen Med, Kobe, Hyogo, Japan.
   [Miwa, Nobuhiko] Prefectural Univ Hiroshima, Fac Life Sci, Hiroshima, Japan.
C3 Osaka Metropolitan University; Osaka Metropolitan University; Nippon
   Dental University
RP Tanaka, Y (corresponding author), Osaka Prefecture Univ, Fac Liberal Arts & Sci, Div Biol, Osaka, Japan.; Tanaka, Y (corresponding author), Osaka Prefecture Univ, Fac Technol, Div Quantum Radiat, Osaka, Japan.
EM yoshitan@las.osakafu-u.ac.jp
RI Xiao, Li/AAX-7766-2020
FU Corporate Japanese Center for Anti-Aging MedSciences [1705]
FX The study was supported in part by a Grant-in-Aid No. 1705 (to LX) for
   the Scientific Research on Anti-Aging Promotion from Corporate Japanese
   Center for Anti-Aging MedSciences, a non-profitable organization
   authenticated by Hiroshima Prefectural Government.
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NR 38
TC 10
Z9 11
U1 2
U2 19
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, Maharashtra, INDIA
SN 2045-9912
J9 MED GAS RES
JI Med. Gas Res.
PD JUL-SEP
PY 2022
VL 12
IS 3
BP 91
EP 99
DI 10.4103/2045-9912.330692
PG 9
WC Medicine, Research & Experimental
WE Emerging Sources Citation Index (ESCI)
SC Research & Experimental Medicine
GA XK0VZ
UT WOS:000727194900004
PM 34854419
OA Green Published
DA 2025-06-11
ER

PT J
AU Thandapilly, SJ
   Louis, X
   Kalt, W
   Raj, P
   Stobart, JL
   Aloud, BM
   Vinqvist-Tymchuk, M
   Yu, LP
   Kaminski, J
   Latruffe, N
   Anderson, CM
   Anderson, HD
   Netticadan, T
AF Thandapilly, Sijo Joseph
   Louis, Xavier
   Kalt, Wilhelmina
   Raj, Pema
   Stobart, Jillian L.
   Aloud, Basma M.
   Vinqvist-Tymchuk, Melinda
   Yu, Liping
   Kaminski, Jacques
   Latruffe, Norbert
   Anderson, Christopher M.
   Anderson, Hope D.
   Netticadan, Thomas
TI Effects of blueberry polyphenolic extract on vascular remodeling in
   spontaneously hypertensive rats
SO JOURNAL OF FOOD BIOCHEMISTRY
LA English
DT Article
DE blueberry polyphenolic extract; cardiac apoptosis; hypertension;
   vascular remodeling
ID BLOOD-PRESSURE; DOUBLE-BLIND; CARDIAC-HYPERTROPHY; OXIDATIVE STRESS;
   CARDIOMYOCYTE APOPTOSIS; RESISTANCE ARTERIES; METABOLIC SYNDROME;
   CONVERTING-ENZYME; HEART; DIET
AB Blueberry is considered a functional food due to various beneficial health effects associated with its consumption. Therefore, we examined the cardiovascular benefits of a blueberry polyphenolic extract in spontaneously hypertensive rats (SHR). Male SHR and Wistar-Kyoto (WKY) rats were administered with blueberry polyphenolic extract for 15 weeks. SHR showed significant augmented media-to-lumen ratio compared to WKY rats and blueberry polyphenolic extract significantly improved media-to-lumen ratio. SHR also had high blood pressure (BP), cardiac remodeling, and diastolic dysfunction and treatment did not affect BP or cardiac structure and function. SHR showed significantly increased the levels of malondialdehyde (MDA) and blueberry polyphenolic extract did not lower MDA. The levels of interleukin 6 and nitrate/nitrite ratio were unaltered in SHR. SHR showed a significant increase in the pro-apoptotic marker, Bax. Blueberry polyphenolic extract significantly lowered Bax. Our study shows that blueberry polyphenolic extract is beneficial in preventing vascular remodeling and cardiac apoptosis. Practical applications Similar to many other berries, blueberries are repertoire of many phytochemicals including polyphenols. Along with its considerably well-established role as a sought after berry, blueberries have been at the forefront of approaches to hharnessing health benefits from plant food sources. Several studies have attempted to unravel the role of blueberry and their major phytochemicals in reducing the risk of cardiovascular diseases and reported their beneficial effects. Our pre-clinical study found that blueberry polyphenolic extract can reduce vascular remodeling in the setting of hypertension. This new finding further suggests the potential of blueberry-based phytochemicals. Further exploration of blueberries and their phytochemicals and positive outcomes from such studies can lead to substantial benefits for consumers and economy as a whole.
C1 [Thandapilly, Sijo Joseph; Raj, Pema; Aloud, Basma M.; Yu, Liping; Netticadan, Thomas] Agr & Agri Food Canada, Winnipeg, MB, Canada.
   [Louis, Xavier; Raj, Pema; Aloud, Basma M.; Yu, Liping; Anderson, Hope D.; Netticadan, Thomas] Canadian Ctr Agrifood Res Hlth & Med, 351 Tache Ave, Winnipeg, MB R2H 2A6, Canada.
   [Kalt, Wilhelmina; Vinqvist-Tymchuk, Melinda] Agr & Agri Food Canada, Kentville, NS, Canada.
   [Stobart, Jillian L.; Anderson, Christopher M.] Univ Manitoba, Dept Pharmacol & Therapeut, Winnipeg, MB, Canada.
   [Kaminski, Jacques; Latruffe, Norbert] Univ Burgundy, Lab Biochem Metab & Nutr, Dijon, France.
   [Anderson, Hope D.] Univ Manitoba, Coll Pharm, Winnipeg, MB, Canada.
   [Netticadan, Thomas] Univ Manitoba, Dept Physiol & Pathophysiol, Winnipeg, MB, Canada.
C3 Agriculture & Agri Food Canada; Agriculture & Agri Food Canada;
   University of Manitoba; Universite Bourgogne Europe; University of
   Manitoba; University of Manitoba
RP Netticadan, T (corresponding author), Canadian Ctr Agrifood Res Hlth & Med, 351 Tache Ave, Winnipeg, MB R2H 2A6, Canada.
EM tnetticadan@sbrc.ca
RI Anderson, Chris/J-7081-2014
OI Anderson, Christopher/0000-0003-0678-3002; Anderson,
   Hope/0000-0001-6570-6678
FU Agriculture and Agri-Food Canada
FX This study was supported by a grant from Agriculture and Agri-Food
   Canada.
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NR 57
TC 3
Z9 3
U1 1
U2 41
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0145-8884
EI 1745-4514
J9 J FOOD BIOCHEM
JI J. Food Biochem.
PD SEP
PY 2022
VL 46
IS 9
AR e14227
DI 10.1111/jfbc.14227
EA MAY 2022
PG 13
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA 4J4DB
UT WOS:000798573400001
PM 35599355
OA gold
DA 2025-06-11
ER

PT J
AU Sohouli, MH
   Fatahi, S
   Sayyari, A
   Olang, B
   Shidfar, F
AF Sohouli, Mohammad Hassan
   Fatahi, Somaye
   Sayyari, Aliakbar
   Olang, Beheshteh
   Shidfar, Farzad
TI Associations between dietary total antioxidant capacity and odds of
   non-alcoholic fatty liver disease (NAFLD) in adults: a case-control
   study
SO JOURNAL OF NUTRITIONAL SCIENCE
LA English
DT Article
DE Dietary total antioxidant capacity; Obesity; Liver enzyme; Non-alcoholic
   fatty liver disease
ID METABOLIC SYNDROME; OXIDATIVE STRESS; REDOX STATUS; CONSUMPTION;
   PREVALENCE; ADHERENCE; FEATURES; MARKERS; JUICE; RISK
AB The relationships between the total antioxidant capacity (TAC) of the diet and the risk of non-alcoholic fatty liver disease (NAFLD) have not previously been assessed. The aim of this study was to assess relationships between DTAC and odds of NAFLD in a case-control study. This case-control study was carried out in 158 patients with NAFLD and 357 healthy individuals aged 18-55 years. Dietary data were collected using validated 168-item quantitative food frequency questionnaires. Triacylglycerols (TAGs), total cholesterol (TC), high-density lipoprotein (HDL-C), low-density lipoprotein (LDL-C) and fasting blood glucose (FBS) concentrations were assessed using enzymatic methods and commercial kits. The DTAC was calculated based on the oxygen radical absorbance capacity of each food reported by the U.S. Department of Agriculture. The mean +/- sd (standard deviation) for age and body mass index (BMI) of the study participants were 43.9 years +/- 5.9 and had 30.5 kg/m(2) +/- 2.6. The NAFLD patients included higher BMI and female proportion, compared with the control group. The NAFLD patients included higher smoking rates, biochemical parameters (TG, TC, LDL-C and FBS) and DTAC scores, compared with control groups (P-value < 0.05). However, patients with NAFLD had lower HDL levels and physical activities, compared with the control group. The highest tertile of DTAC showed lower odds of NAFLD, compared with the lowest tertile. This association was significant after adjustment for potential confounders (OR, 0.19; 95 % CI, 0.9-0.34; P for trend 0.001). Findings suggest that the promotion of naturally increased antioxidant capacities may help prevent odds of NAFLD.
C1 [Sohouli, Mohammad Hassan; Fatahi, Somaye; Shidfar, Farzad] Iran Univ Med Sci, Sch Publ Hlth, Dept Nutr, Tehran 1449614535, Iran.
   [Sohouli, Mohammad Hassan] Iran Univ Med Sci, Fac Publ Hlth Branch, Student Res Comm, Tehran 1449614535, Iran.
   [Sayyari, Aliakbar; Olang, Beheshteh] Shahid Beheshti Univ Med Sci, Res Inst Childrens Hlth, Pediat Gastroenterol Hepatol & Nutr Res Ctr, Tehran 1546815514, Iran.
C3 Iran University of Medical Sciences; Iran University of Medical
   Sciences; Shahid Beheshti University Medical Sciences
RP Shidfar, F (corresponding author), Iran Univ Med Sci, Sch Publ Hlth, Dept Nutr, Tehran 1449614535, Iran.
EM shidfar.f@iums.ac.ir
RI Shidfar, Farzad/H-6651-2018; Olang, Beheshteh/S-8249-2019
OI sohouli, mohammadhassan/0000-0002-6723-7112
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NR 45
TC 20
Z9 20
U1 0
U2 6
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
SN 2048-6790
J9 J NUTR SCI
JI J. Nutr. Sci.
PD NOV 11
PY 2020
VL 9
AR e48
DI 10.1017/jns.2020.39
PG 7
WC Nutrition & Dietetics
WE Emerging Sources Citation Index (ESCI)
SC Nutrition & Dietetics
GA OP8MK
UT WOS:000588344200001
PM 33244400
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Shields, CA
   Poudel, B
   McPherson, KC
   Brown, AK
   Ekperikpe, US
   Browning, E
   Sutton, L
   Cornelius, DC
   Williams, JM
AF Shields, Corbin A.
   Poudel, Bibek
   McPherson, Kasi C.
   Brown, Andrea K.
   Ekperikpe, Ubong S.
   Browning, Evan
   Sutton, Lamari
   Cornelius, Denise C.
   Williams, Jan M.
TI Treatment With Gemfibrozil Prevents the Progression of Chronic Kidney
   Disease in Obese Dahl Salt-Sensitive Rats
SO FRONTIERS IN PHYSIOLOGY
LA English
DT Article
DE obesity; renal injury; SS rat; SS(LepR)mutant rat; lipid accumulation;
   gemfibrozil
ID BODY-MASS INDEX; INITIATED METABOLIC SYNDROME; ALTERED RENAL
   HEMODYNAMICS; FATTY KIDNEY; PEROXISOME PROLIFERATORS; BLOOD-PRESSURE;
   RISK; FENOFIBRATE; HYPERTENSION; STRESS
AB Recently, we reported that Dahl salt-sensitive leptin receptor mutant (SS(LepR)mutant) rats exhibit dyslipidemia and renal lipid accumulation independent of hyperglycemia that progresses to chronic kidney disease (CKD). Therefore, in the current study, we examined the effects of gemfibrozil, a lipid-lowering drug (200 mg/kg/day, orally), on the progression of renal injury in SS and SS(LepR)mutant rats for 4 weeks starting at 12 weeks of age. Plasma triglyceride levels were markedly elevated in the SS(LepR)mutant strain compared to SS rats (1193 +/- 243 and 98 +/- 16 mg/day, respectively). Gemfibrozil treatment only reduced plasma triglycerides in the SS(LepR)mutant strain (410 +/- 79 mg/dL). MAP was significantly higher in the SS(LepR)mutant strain vs. SS rats at the end of the study (198 +/- 7 vs. 165 +/- 7 mmHg, respectively). Administration of gemfibrozil only lowered MAP in SS(LepR)mutant rats (163 +/- 8 mmHg). During the course of the study, proteinuria increased to 125 +/- 22 mg/day in SS rats. However, proteinuria did not change in the SS(LepR)mutant strain and remained near baseline (693 +/- 58 mg/day). Interestingly, treatment with gemfibrozil increased the progression of proteinuria by 77% in the SS(LepR)mutant strain without affecting proteinuria in SS rats. The renal injury in the SS(LepR)mutant strain progressed to CKD. Moreover, the kidneys from SS(LepR)mutant rats displayed significant glomerular injury with mesangial expansion and increased renal lipid accumulation and fibrosis compared to SS rats. Treatment with gemfibrozil significantly reduced glomerular injury and lipid accumulation and improved renal function. These data indicate that reducing plasma triglyceride levels with gemfibrozil inhibits hypertension and CKD associated with obesity in SS(LepR)mutant rats.
C1 [Shields, Corbin A.; Poudel, Bibek; McPherson, Kasi C.; Brown, Andrea K.; Ekperikpe, Ubong S.; Browning, Evan; Sutton, Lamari; Cornelius, Denise C.; Williams, Jan M.] Univ Mississippi, Med Ctr, Dept Expt Therapeut & Pharmacol, Jackson, MS 39216 USA.
   [Cornelius, Denise C.] Univ Mississippi, Med Ctr, Dept Emergency Med, Jackson, MS 39216 USA.
C3 University of Mississippi; University of Mississippi Medical Center;
   University of Mississippi; University of Mississippi Medical Center
RP Williams, JM (corresponding author), Univ Mississippi, Med Ctr, Dept Expt Therapeut & Pharmacol, Jackson, MS 39216 USA.
EM jmwilliams5@umc.edu
RI Ekperikpe, Ubong/AFP-4571-2022
OI Ekperikpe, Ubong/0000-0002-9962-5371; Poudel, Dr.
   Bibek/0000-0003-1353-7002
FU National Institutes of Diabetes and Digestive and Kidney Diseases of the
   National Institutes of Health (NIH/NIDDK) [DK109133]; National Heart,
   Lung and Blood Institute of the National Institutes of Health
   (NIH/NHLBI) [HL130456, HL151407]; NIGMS; Mississippi INBRE
   [P20GM103476]; Obesity, Cardiorenal and Metabolic Diseases-COBRE
   [P20GM104357]; Mississippi Center of Excellence in Perinatal Research
   (MS-CEPR)-COBRE [P20GM121334]
FX This work was financially supported by the National Institutes of
   Diabetes and Digestive and Kidney Diseases of the National Institutes of
   Health (NIH/NIDDK, DK109133) awarded to JW, the National Heart, Lung and
   Blood Institute of the National Institutes of Health (NIH/NHLBI,
   HL130456 and HL151407) awarded to DC. The work performed through the
   UMMC Molecular and Genomics Facility was supported, in part, by funds
   from the NIGMS, including the Mississippi INBRE (P20GM103476), Obesity,
   Cardiorenal and Metabolic Diseases-COBRE (P20GM104357), and the
   Mississippi Center of Excellence in Perinatal Research (MS-CEPR)-COBRE
   (P20GM121334). The content was solely the responsibility of the authors
   and does not necessarily represent the official views of the National
   Institutes of Health.
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NR 76
TC 1
Z9 2
U1 0
U2 4
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-042X
J9 FRONT PHYSIOL
JI Front. Physiol.
PD SEP 18
PY 2020
VL 11
AR 566403
DI 10.3389/fphys.2020.566403
PG 12
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA NY5QQ
UT WOS:000576444200001
PM 33071820
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Mohammadi, M
   Khodarahmi, M
   Kahroba, H
   Farhangi, MA
   Vajdi, M
AF Mohammadi, Mohaddeseh
   Khodarahmi, Mahdieh
   Kahroba, Houman
   Farhangi, Mahdieh Abbasalizad
   Vajdi, Mahdi
TI The interaction between dietary Non-Enzymatic Antioxidant Capacity
   (NEAC) with variants of Melanocortin-4 receptor (MC4R)
   18q21.23-rs17782313 locus on hypothalamic hormones and cardio-metabolic
   risk factors in obese individuals from Iran
SO NUTRITIONAL NEUROSCIENCE
LA English
DT Article
DE Obesity; antioxidants; oxidative stress; gene-diet interaction;
   polymorphism; TAC; metabolic factors; Melanocortin-4 receptor
ID SERUM TRIGLYCERIDE LEVELS; COMMON GENETIC-VARIATION; FOOD-INTAKE;
   ENERGY; POLYMORPHISM; RS17782313; NUTRITION; WEIGHT; STATES; MASS
AB Background:In the current study, we aimed to evaluate the interaction between dietary Non-Enzymatic Antioxidant Capacity (NEAC) and rs17782313 polymorphism on hypothalamic hormones and cardio-metabolic risk factors. Methods:A total of 287 subjects (aged 20-50 years, 147 males and 140 females) enrolled in the cross-sectional study. Dietary NEAC was assessed using databases of NEAC measurements compiled from outcomes for three different analyses: oxygen radical absorbance capacity (ORAC), ferric reducing-antioxidant power (FRAP), and total radical-trapping antioxidant parameter (TRAP) and genotyping for the near MC4R rs17782313 was carried out by Polymerase chain reaction-restriction fragments length polymorphism (PCR-RFLP) method. Results:The significant interactions were found between adherence to the dietary NEAC and MC4R rs17782313 in relation to high-density lipoprotein-cholesterol (HDL-C), glucose, alpha-melanocyte stimulating hormone (alpha-MSH), insulin and quantitative insulin sensitivity check index (QUICKI) (P-Interaction = 0.03, 0.01, 0.04, 0.04 and 0.04, respectively). In homozygous subjects for the minor allele, the serum insulin level and QUICKI in participants with the highest adherence to TRAP were significantly higher than those with the lowest adherence (p < 0.001). There was a significant inverse association between high ORAC score and risk of metabolic syndrome even after adjusting for potential confounders (OR: 0.33; 95%CI:0.13-0.81) and also a significant inverse association between high NEAC (ORAC, FRAP and TRAP assays) score and high triglyceride (TG) level was found in obese adults. Conclusion:In conclusion, our study found for the first time that the NEAC significantly interacts with thers17782313genotypes to influence several metabolic risk factors in obesity.
C1 [Mohammadi, Mohaddeseh] Tabriz Univ Med Sci, Student Res Comm, Tabriz, Iran.
   [Khodarahmi, Mahdieh] Tabriz Univ Med Sci, Nutr Res Ctr, Tabriz, Iran.
   [Kahroba, Houman] Tabriz Univ Med Sci, Mol Med Res Ctr, Tabriz, Iran.
   [Farhangi, Mahdieh Abbasalizad; Vajdi, Mahdi] Tabriz Univ Med Sci, Drug Appl Res Ctr, Tabriz, Iran.
C3 Tabriz University of Medical Science; Tabriz University of Medical
   Science; Tabriz University of Medical Science; Tabriz University of
   Medical Science
RP Farhangi, MA (corresponding author), Daneshgah Blvd, Tabriz, Iran.
EM abbasalizadfarhangim@gmail.com
RI Farhangi, Mahdieh/AAC-6758-2019; khodarahmi, mahdieh/AAJ-9853-2020;
   Vajdi, Mahdi/GZG-7674-2022
OI Vajdi, Mahdi/0000-0002-2828-1161
FU Tabriz University of Medical Sciences [IR.TBZMED.REC.1397.237,
   IR.TBZMED.REC.1399.208]
FX This work has been supported by a grant from undersecretary of Tabriz
   University of Medical Sciences (identifier: IR.TBZMED.REC.1397.237 and
   IR.TBZMED.REC.1399.208).
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NR 89
TC 2
Z9 2
U1 0
U2 2
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1028-415X
EI 1476-8305
J9 NUTR NEUROSCI
JI Nutr. Neurosci.
PD OCT 2
PY 2020
VL 23
IS 10
BP 824
EP 837
DI 10.1080/1028415X.2020.1780738
EA JUN 2020
PG 14
WC Neurosciences; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Nutrition & Dietetics
GA NO8VD
UT WOS:000546438000001
PM 32558632
DA 2025-06-11
ER

PT J
AU Crnobrnja, V
   Ilincic, B
   Stokic, E
   Basta-Nikolic, M
   Slankamenac, S
   Milosavljevic, AS
   Zeravica, R
   Cabarkapa, V
AF Crnobrnja, Veljko
   Ilincic, Branislava
   Stokic, Edita
   Basta-Nikolic, Marijana
   Slankamenac, Sonja
   Milosavljevic, Anastazija Stojsic
   Zeravica, Radmila
   Cabarkapa, Velibor
TI Association between ultrasonographically measured visceral fat tissue
   thickness and proinflammatory adipokines in obesity
SO VOJNOSANITETSKI PREGLED
LA English
DT Article
DE adipokines; adipose tissue; anthropometry; metabolic diseases; obesity;
   resistin; severity of illness index; ultrasonography
ID ADIPOSE-TISSUE; INSULIN SENSITIVITY; METABOLIC SYNDROME;
   ENDOTHELIAL-CELLS; OXIDATIVE STRESS; RESISTIN; CHEMERIN; INFLAMMATION;
   PLASMA; ATHEROSCLEROSIS
AB Background/Aim. Obesity status can be assessed with numerous anthropometric, morphological and functional indices and this study was designed to assess relationship among them. The aim of this study was to investigate associations between anthropometric indices, ultrasonography measurement of visceral and subcutaneous fat tissue thickness and certain proinflammatory adipokines level. Methods. This cross-sectional study comprised a consecutive sample of 60 obese respondents without obesity-related comorbidities, and 20 age-matched healthy normal-weight controls. Anthropometric [body mass index (BMI), waist circumference (WC), neck circumference (NC), body fat, a body shape index (ABSI)], and ultrasonographic indices [thickness of intraabdominal fatt tissue (IAFT), visceral fat (VF), maximum subcutaneous fat (Max SFT), minimal subcutaneous fat (Min SFT)], and serum levels of chemerin and resistin were assessed in all subjects. Results. All anthropometric indices showed statistically significant differences between study groups. The mean IAFT, Max SFT, Min SFT and VF were significantly higher in the obese group compared to controls (p < 0.01, for all). Serum levels of chemerin and resistin correlated positively with BMI, percentage of fat adipose tissue (FAT, %), total FAT (kg), and VF (p < 0.05, for all). Also, we observed significant correlation between resistin and NC (r = 0.23, p = 0.03) and ABSI (r = 0.22, p = 0.04). In multivariable linear regression analysis, chemerin (beta = 0.23; p = 0.008) and resistin (beta = 0.43; p = 0.002) were independently and significantly associated only with VF. Conclusion. Obesity indices, both classical and newer ones, are in positive, statistically significant correlation with the level of proinflammatory cytokines. Ultrasonographically measured VF thickness, independently associated with adipokine levels, may improve assessment of proinflammatory fat tissue characteristics. Further studies are needed to precisely define the use of ultrasonographic fat tissue measurements into clinical practice.
C1 [Crnobrnja, Veljko; Ilincic, Branislava; Zeravica, Radmila; Cabarkapa, Velibor] Clin Ctr Vojvodina, Ctr Lab Med, Novi Sad, Serbia.
   [Stokic, Edita; Slankamenac, Sonja; Milosavljevic, Anastazija Stojsic] Clin Ctr Vojvodina, Clin Diabet Endocrinol & Metab Dis, Novi Sad, Serbia.
   [Basta-Nikolic, Marijana] Clin Ctr Vojvodina, Ctr Radiol, Novi Sad, Serbia.
   [Crnobrnja, Veljko; Ilincic, Branislava; Stokic, Edita; Basta-Nikolic, Marijana; Zeravica, Radmila; Cabarkapa, Velibor] Univ Novi Sad, Fac Med, Novi Sad, Serbia.
   [Milosavljevic, Anastazija Stojsic] Inst Cardiovasc Dis, Sremska Kamenica, Serbia.
C3 University of Novi Sad
RP Ilincic, B (corresponding author), Univ Novi Sad, Fac Med, Dept Pathophysiol & Lab Med, Hajduk Veljkova 3, Novi Sad 21000, Serbia.
EM BRANISLAVA.ILINCIC@mf.uns.ac.rs
OI Basta Nikolic, Marijana/0000-0003-2769-886X; Zeravica,
   Radmila/0000-0002-6266-3729
FU Provincial Secretariat for Science and Technological Development of the
   Autonomous Province of Vojvodina, Serbia [114-451-2013/2016-01];
   Ministry of Education, Science and Technological Development of the
   Republic of Serbia [III46005]
FX This study was supported by the Provincial Secretariat for Science and
   Technological Development of the Autonomous Province of Vojvodina,
   Serbia (grant No 114-451-2013/2016-01), and the Ministry of Education,
   Science and Technological Development of the Republic of Serbia (grant
   No III46005).
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NR 42
TC 0
Z9 0
U1 0
U2 0
PU MILITARY MEDICAL ACAD-INI
PI BELGRADE
PA CRNOTRAVSKA 17, PO BOX 33-35, BELGRADE, 11040, SERBIA
SN 0042-8450
EI 2406-0720
J9 VOJNOSANIT PREGL
JI Vojnosanit. Pregl.
PY 2020
VL 77
IS 11
BP 1146
EP 1153
DI 10.2298/VSP181003198C
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA PC2YD
UT WOS:000596871900005
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Afarideh, M
   Esteghamati, VZ
   Ganji, M
   Heidari, B
   Esteghamati, S
   Lavasani, S
   Ahmadi, M
   Tafakhori, A
   Nakhjavani, M
   Esteghamati, A
AF Afarideh, Mohsen
   Esteghamati, Violet Zaker
   Ganji, Morsaleh
   Heidari, Behnam
   Esteghamati, Sadaf
   Lavasani, Seyedsoroush
   Ahmadi, Mona
   Tafakhori, Abbas
   Nakhjavani, Manouchehr
   Esteghamati, Alireza
TI Associations of Serum S100B and S100P With the Presence and
   Classification of Diabetic Peripheral Neuropathy in Adults With Type 2
   Diabetes: A Case-Cohort Study
SO CANADIAN JOURNAL OF DIABETES
LA English
DT Article
DE classification; diabetic peripheral neuropathy; risk factor; S10013;
   S100P
ID GLYCATION END-PRODUCTS; GROWTH-FACTOR 21; METABOLIC SYNDROME; OXIDATIVE
   STRESS; GLIAL REACTIVITY; RECEPTOR; DISEASE; MARKER; RAGE; HIPPOCAMPUS
AB Objectives: Novel biomarkers of diabetic peripheral neuropathy provide potentially useful information for early identification and treatment of diabetic neuropathy, ultimately serving to reduce the burden of disease. This study was designed to investigate the potential associations of serum S100B and S100P (calcium-modulated proteins) with the presence and classification of diabetic peripheral neuropathy in adults with type 2 diabetes.
   Methods: In a case-cohort setting, the data of 44 participants diagnosed with diabetic peripheral neuropathy, 44 control participants with type 2 diabetes but free of peripheral neuropathy and 87 healthy control individuals were collected and analyzed.
   Results: Serum S100P concentrations were elevated in participants with diabetic peripheral neuropathy compared with their controls with type 2 diabetes (median [IQR]: 2,235 pg/mL [1,497.5 to 2,680] vs.1,200 pg/mL [975 to 1,350)1, respectively; p<0.001). Conversely, serum 5100B values were comparable in these 2 groups (p=0.570). Those with the typical diabetic peripheral neuropathy had significantly higher serum S100P levels compared to their counterparts with the atypical group of diabetic peripheral neuropathies (p=0.048). The independent significant association between serum S100P and diabetic peripheral neuropathy persisted into the multivariable adjusted logistic regression model (OR for S100P: 1.004 [95% CI 1.002 to 1.006]; p<0.001).
   Conclusions: The present study's findings demonstrated that serum S100P is a more significant indicator of peripheral neuropathy in type 2 diabetes than is serum S100B. Prospective longitudinal studies are required to confirm the prognostic value of baseline serum S100P to predict incident peripheral neuropathy in people with diabetes. (C) 2019 Canadian Diabetes Association.
C1 [Afarideh, Mohsen; Esteghamati, Violet Zaker; Ganji, Morsaleh; Heidari, Behnam; Esteghamati, Sadaf; Nakhjavani, Manouchehr; Esteghamati, Alireza] Univ Tehran Med Sci, Sch Med, Vali Asr Hosp, Endocrinol & Metab Res Ctr, Tehran, Iran.
   [Lavasani, Seyedsoroush] Iran Univ Med Sci, Dept Virol, Tehran, Iran.
   [Ahmadi, Mona; Tafakhori, Abbas] Univ Tehran Med Sci, Sch Med, Imam Khomeini Hosp Complex, Iranian Ctr Neurol Res, Tehran, Iran.
C3 Tehran University of Medical Sciences; Iran University of Medical
   Sciences; Tehran University of Medical Sciences
RP Esteghamati, A (corresponding author), Univ Tehran Med Sci, Vali Asr Hosp, Endocrinol & Metab Res Ctr, POB 13145-784, Tehran, Iran.
EM esteghamati@tums.ac.ir
RI Afarideh, Mohsen/H-8945-2019; Nakhjavani, Manouchehr/J-3704-2019
OI Esteghamati, Alireza/0000-0001-5114-3982
CR Afarideh M, 2017, DIABETES METAB, V43, P180, DOI 10.1016/j.diabet.2016.07.032
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NR 53
TC 13
Z9 13
U1 2
U2 8
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1499-2671
J9 CAN J DIABETES
JI Can. J. Diabetes
PD JUL
PY 2019
VL 43
IS 5
BP 336
EP +
DI 10.1016/j.jcjd.2019.01.003
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA IF2MX
UT WOS:000472912500008
PM 30872108
DA 2025-06-11
ER

PT J
AU Belli, AA
   Altun, I
AF Belli, Asli Akin
   Altun, Ibrahim
TI Assessment of Framingham risk score and systemic coronary risk
   evaluation in rosacea patients
SO DERMATOLOGICA SINICA
LA English
DT Article
DE cardiovascular diseases; risk factors; rosacea
ID ENDOPLASMIC-RETICULUM STRESS; CARDIOVASCULAR-DISEASE; COMORBIDITIES;
   SEVERITY; AGE
AB Background/Objective(s): Although some studies with contrary results have been reported, recent studies suggest an association between rosacea and cardiovascular diseases. However, no study has investigated the frequency of cardiovascular risk in rosacea patients using a validated scale. We aimed to determine the frequency of cardiovascular risk by the Framingham Risk Score (FRS) and Systemic Coronary Risk Evaluation (SCORE) in rosacea patients.
   Methods: We conducted a caseecontrol study including 85 rosacea patients and 90 controls. Demographic information, rosacea duration (obtained by self-report of the patients) and subtype, smoking history, lipid parameters, blood pressure, use of antihypertensive drug, fasting blood glucose, body mass index, family history of coronary artery disease, presence of metabolic syndrome and insulin resistance, and total points of the FRS and SCORE were recorded.
   Results: Eighty-five rosacea patients (65 females and 20 males; mean age, 50.63 years) and 90 controls (67 females and 23 males; mean age, 50.79 years) were included in the study. Of the 85 rosacea patients, 44 had the erythematotelangiectatic type and 41 had the papulopustular type. The mean SCORE and FRS levels were not significantly different between the rosacea and control groups. Ten patients (12.5% vs. 11.8%) were estimated to be at high risk by both the SCORE and FRS models. The SCORE levels correlated with the rosacea duration. The patients with the papulopustular type had significantly higher cardiovascular risk than those with the erythematotelangiectatic type.
   Conclusion: Rosacea patients did not have an increased risk of cardiovascular disease, as estimated by the two validated models. However, further studies are needed with the four subtypes of rosacea to evaluate cardiovascular risk factors separately. Copyright (C) 2017, Taiwanese Dermatological Association. Published by Elsevier Taiwan LLC.
C1 [Belli, Asli Akin] Mugla Sitki Kocman Univ Training & Res Hosp, Dept Dermatol, Mugla, Turkey.
   [Altun, Ibrahim] Mugla Sitki Kocman Univ, Sch Med, Dept Cardiol, Mugla, Turkey.
C3 Mugla Sitki Kocman University
RP Belli, AA (corresponding author), Mugla Sitki Kocman Univ Training & Res Hosp, Ismet Catak Caddesi,Orhaniye Mahallesi, TR-48000 Mugla, Turkey.
EM dr_asliakin@hotmail.com
RI Altun, Ibrahim/B-4425-2015
CR Belli AA, 2016, EUR J DERMATOL, V26, P260, DOI 10.1684/ejd.2016.2748
   Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
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   Duman N, 2014, J EUR ACAD DERMATOL, V28, P1165, DOI 10.1111/jdv.12234
   Edfeldt K, 2006, ARTERIOSCL THROM VAS, V26, P1551, DOI 10.1161/01.ATV.0000223901.08459.57
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   Graham I, 2007, EUR HEART J, V28, P2375, DOI 10.1093/eurheartj/ehm316
   Hua TC, 2015, J AM ACAD DERMATOL, V73, P249, DOI 10.1016/j.jaad.2015.04.028
   Kim S, 2014, INNATE IMMUN-LONDON, V20, P799, DOI 10.1177/1753425913508593
   Kunutsor SK, 2016, ATHEROSCLEROSIS, V245, P143, DOI 10.1016/j.atherosclerosis.2015.12.021
   Melnik BC, 2014, EXP DERMATOL, V23, P868, DOI 10.1111/exd.12517
   Pirincci E, 2016, J WOMEN AGING, V28, P238, DOI 10.1080/08952841.2014.951231
   Rainer BM, 2015, J AM ACAD DERMATOL, V73, P604, DOI 10.1016/j.jaad.2015.07.009
   Baeta IGR, 2014, AN BRAS DERMATOL, V89, P735, DOI 10.1590/abd1806-4841.20142874
   Rosa DJF, 2012, J EUR ACAD DERMATOL, V26, P348, DOI 10.1111/j.1468-3083.2011.04076.x
   Takci Z, 2015, J EUR ACAD DERMATOL, V29, P367, DOI 10.1111/jdv.12556
   Yamasaki K, 2011, J INVEST DERM SYMP P, V15, P12, DOI 10.1038/jidsymp.2011.4
NR 19
TC 9
Z9 10
U1 0
U2 8
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, 400059, INDIA
SN 1027-8117
EI 2223-330X
J9 DERMATOL SIN
JI Dermatol. Sin.
PD SEP
PY 2017
VL 35
IS 3
BP 127
EP 130
DI 10.1016/j.dsi.2017.03.006
PG 4
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA FF4II
UT WOS:000408902300004
OA gold
DA 2025-06-11
ER

PT J
AU Tuck, NL
   Adams, KS
   Consedine, NS
AF Tuck, Natalie L.
   Adams, Kathryn S.
   Consedine, Nathan S.
TI Does the ability to express different emotions predict different indices
   of physical health? A skill-based study of physical symptoms and heart
   rate variability
SO BRITISH JOURNAL OF HEALTH PSYCHOLOGY
LA English
DT Article
ID POSTTRAUMATIC-STRESS-DISORDER; RESPIRATORY SINUS ARRHYTHMIA; CHRONIC
   PAIN INTENSITY; ANGER EXPRESSION; CARDIOVASCULAR-DISEASE;
   INDIVIDUAL-DIFFERENCES; REGULATORY FLEXIBILITY; DIVERGENT ASSOCIATIONS;
   REGULATION STRATEGIES; METABOLIC SYNDROME
AB Objectives. The outward expression of emotion has been frequently associated with better health outcomes, whereas suppressing emotion is thought to contribute to worse physical health. However, work has typically focused on trait expressive tendencies and the possibility that individual differences in the ability to express specific emotions may also be associated with health has not been widely tested.
   Design. A cross-sectional study of community dwelling adults.
   Methods. One hundred and twenty-eight participants aged 18-88 years completed questionnaires assessing demographics and health status, before attending a testing session in which resting heart rate variability (HRV) was assessed. Participants then completed a performance-based test of expressive regulatory skill in which they were instructed to enhance and suppress their emotional expressions while they watched film clips validated to elicit amusement, sadness, and anger. Participants rated subjective emotional experience before and after each clip, and their degree of expressivity was scored using FACS-based Noldus FaceReader.
   Results. Missing data resulted in a final sample size of 117. Linear regressions controlling for age, sex, diagnoses, and trait emotion revealed that greater ability to enhance sad expressions was associated with higher HRV while the ability to enhance expressions of joy was associated with lower symptom interference. In parallel models, the ability to flexibly regulate (both enhance and suppress) expressions of joy and sadness was also associated with lower symptom interference.
   Conclusions. Findings suggest that the ability to regulate expressions of both sadness and joy is associated with health indices even when controlling for trait affect and potential confounds. The present findings offer early evidence that individual differences in the ability to regulate the outward expression of emotion may be relevant to health and suggest that expressive regulatory skills offer a novel avenue for research and intervention.
C1 [Tuck, Natalie L.; Consedine, Nathan S.] Univ Auckland, Dept Psychol Med, Auckland, New Zealand.
   [Adams, Kathryn S.] Univ Auckland, Sch Med, Auckland, New Zealand.
C3 University of Auckland; University of Auckland
RP Consedine, NS (corresponding author), Univ Auckland, Fac Med & Hlth Sci, Dept Psychol Med, Private Bag 92019, Auckland, New Zealand.
EM n.consedine@auckland.ac.nz
RI Consedine, Nathan/A-8876-2012; Tuck, Natalie/AAP-7769-2020
OI Tuck, Natalie/0000-0002-2739-6389
FU University Of Auckland School Of Medicine; Postgraduate Research Fund
FX Financial support for the study was provided by the University Of
   Auckland School Of Medicine's doctoral study funds and the Postgraduate
   Research Fund.
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NR 116
TC 6
Z9 8
U1 0
U2 35
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1359-107X
EI 2044-8287
J9 BRIT J HEALTH PSYCH
JI Br. J. Health Psychol.
PD SEP
PY 2017
VL 22
IS 3
BP 502
EP 523
DI 10.1111/bjhp.12242
PG 22
WC Psychology, Clinical
WE Social Science Citation Index (SSCI)
SC Psychology
GA FG1JU
UT WOS:000409552500008
PM 28452399
DA 2025-06-11
ER

PT J
AU Gileles-Hillel, A
   Almendros, I
   Khalyfa, A
   Nigdelioglu, R
   Qiao, ZH
   Hamanaka, RB
   Mutlu, GM
   Akbarpour, M
   Gozal, D
AF Gileles-Hillel, Alex
   Almendros, Isaac
   Khalyfa, Abdelnaby
   Nigdelioglu, Recep
   Qiao, Zhuanhong
   Hamanaka, Robert B.
   Mutlu, Gokhan M.
   Akbarpour, Mahzad
   Gozal, David
TI Prolonged Exposures to Intermittent Hypoxia Promote Visceral White
   Adipose Tissue Inflammation in a Murine Model of Severe Sleep Apnea:
   Effect of Normoxic Recovery
SO SLEEP
LA English
DT Article
DE intermittent hypoxia; insulin resistance; macrophages; metabolic
   dysfunction; sleep apnea
ID POSITIVE AIRWAY PRESSURE; DIET-INDUCED OBESITY; MOUSE MODEL;
   INSULIN-RESISTANCE; METABOLIC DYSFUNCTION; LIPOPROTEIN-LIPASE;
   ENERGY-METABOLISM; OXIDATIVE STRESS; FAT DISTRIBUTION; HUMAN ADIPOCYTES
AB Study Objective: Increased visceral white adipose tissue (vWAT) mass results in infiltration of inflammatory macrophages that drive inflammation and insulin resistance. Patients with obstructive sleep apnea (OSA) suffer from increased prevalence of obesity, insulin resistance, and metabolic syndrome. Murine models of intermittent hypoxia (IH) mimicking moderate-severe OSA manifest insulin resistance following short-term IH. We examined in mice the effect of long-term IH on the inflammatory cellular changes within vWAT and the potential effect of normoxic recovery (IH-R).
   Methods: Male C57BL/6J mice were subjected to IH for 20 weeks, and a subset was allowed to recover in room air (RA) for 6 or 12 weeks (IH-R). Stromal vascular fraction was isolated from epididymal vWAT and mesenteric vWAT depots, and single-cell suspensions were prepared for flow cytometry analyses, reactive oxygen species (ROS), and metabolic assays.
   Results: IH reduced body weight and vWAT mass and IH-R resulted in catch-up weight and vWAT mass. IH-exposed vWAT exhibited increased macrophage counts (ATMs) that were only partially improved in IH-R. IH also caused a proinflammatory shift in ATMs (increased Ly6c((hi))(+) and CD36(+) ATMs). These changes were accompanied by increased vWAT insulin resistance with only partial improvements in IH-R. In addition, ATMs exhibited increased ROS production, altered metabolism, and changes in electron transport chain, which were only partially improved in IH-R.
   Conclusion: Prolonged exposures to IH during the sleep period induce pronounced vWAT inflammation and insulin resistance despite concomitant vWAT mass reductions. These changes are only partially reversible after 3 months of normoxic recovery. Thus, long-lasting OSA may preclude complete reversibility of metabolic changes.
C1 [Gileles-Hillel, Alex; Almendros, Isaac; Khalyfa, Abdelnaby; Qiao, Zhuanhong; Akbarpour, Mahzad; Gozal, David] Univ Chicago, Pritzker Sch Med, Dept Pediat, Sect Pediat Sleep Med,Biol Sci Div, Chicago, IL 60637 USA.
   [Gileles-Hillel, Alex; Almendros, Isaac; Khalyfa, Abdelnaby; Qiao, Zhuanhong; Akbarpour, Mahzad; Gozal, David] Univ Chicago, Dept Pediat, Pritzker Sch Med, Sect Pulmonol,Biol Sci Div, Chicago, IL 60637 USA.
   [Nigdelioglu, Recep; Hamanaka, Robert B.; Mutlu, Gokhan M.] Univ Chicago, Pritzker Sch Med, Dept Med, Sect Pulm & Crit Care,Biol Sci Div, Chicago, IL 60637 USA.
C3 University of Chicago; University of Chicago; University of Chicago
RP Gozal, D (corresponding author), Univ Chicago, Pritzker Sch Med, Dept Pediat, Sect Pediat Sleep Med,Biol Sci Div,KCBD, Room 4100,900 E 57th St,Mailbox 4, Chicago, IL 60637 USA.
EM dgozal@uchicago.edu
RI Gozal, David/ABH-3805-2020; Akbarpour, Mahzad/AAG-8506-2019; Khalyfa,
   Abdelnaby/M-9498-2017; Mutlu, Gokhan/HIR-2545-2022; qiao,
   Zhuanhong/A-1117-2009; Gileles-Hillel, Alexander/K-6674-2019; Almendros,
   Isaac/A-8251-2016
OI Akbarpour, Mahzad/0000-0001-9260-1716; Almendros,
   Isaac/0000-0002-1998-9379; Gileles-Hillel, Alex/0000-0002-0656-905X
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NR 67
TC 45
Z9 46
U1 0
U2 4
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
EI 1550-9109
J9 SLEEP
JI Sleep
PD MAR 1
PY 2017
VL 40
IS 3
AR zsw074
DI 10.1093/sleep/zsw074
PG 10
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA ER6ND
UT WOS:000398921100010
PM 28329220
OA Bronze
DA 2025-06-11
ER

PT J
AU Kou, GN
   Zhao, Z
   Dong, XY
   Zhang, Y
   Guo, LY
   Zhou, ZQ
AF Kou, Guangning
   Zhao, ZiYan
   Dong, Xin-Ying
   Zhang, Ying
   Guo, Li-Ya
   Zhou, Zhi-Qin
TI EFFECTS OF CITRUS FRUITS ON BLOOD LIPID LEVELS: A SYSTEMATIC REVIEW AND
   META-ANALYSIS
SO ACTA MEDICA MEDITERRANEA
LA English
DT Article
DE citrus fruits; total cholesterol; triglycerides; high-density
   lipoprotein-cholesterol; low-density lipoprotein-cholesterol;
   meta-analysis
ID GAMMA-GLUTAMYL-TRANSFERASE; METABOLIC SYNDROME; OXIDATIVE STRESS; ORANGE
   JUICE; VITAMIN-C; DISEASE; CHOLESTEROL; FLAVONOIDS; CANCER; RISK
AB Background: For management of hyperlipidemia and cardiovascular diseases, total fruit consumption that is increased is used. However, it is still not known if different subtypes like the citruses can play a role that is preventative. The response of the treatment and its magnitude is associated with the citrus in the improvement of the Total Cholesterol (TC), the Tri-glycerides (TG), the High Density Lipoprotein-Cholesterol (HDL-C), and the Low Density Lipoprotein-Cholesterol (LDL-C) which has not, until now been quantified systematically.
   Method: The core objective of our analysis is t reviewing and conducting of the quantitative analyses of these studies which are evaluated for the effects of the ingestion of citrus into the blood lipid parameters. There are pertinent studies that are identified using a systematically proceeded PubMed search, and also the EMBASE of the China National Knowledge Infrastructure and the Cochrane Library until March 2017. The quality of study has been assessed by means of using a modified Jadad scale. These results were viewed on the basis of mean differences (WMD) with a confidence interval (CI) of 95% by making use of an unplanned impacts model.
   Results: Randomized controlled testing with 7 in number having 282 participants had been included. According to the analysis a citrus fruit intake was significant in reducing TC (-5.18 mg/dL, 95% CI:-10.21 to -0.14, p=0.04) and LDL-C (-7.64 mg/dL, 95% CI:-12.27 to -3.01, p=0.001) in the participants, but the other lipid indexes were not significantly altered.
   Conclusion: The results showed that in taking the citric fruitescan reduce the TC and the LDL-C and the effect and the size were moderate remaining ineffective on the HDL-C and the TG levels.
C1 [Zhao, ZiYan; Dong, Xin-Ying; Zhou, Zhi-Qin] Southwest Univ, Coll Hort & Landscape Architecture, Chongqing, Peoples R China.
   [Kou, Guangning; Zhao, ZiYan; Dong, Xin-Ying; Zhou, Zhi-Qin] Chongqing Southwest Inst Fruits Nutr, Chongqing, Peoples R China.
   [Zhang, Ying] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Wuhan, Hubei, Peoples R China.
   [Guo, Li-Ya] Southwest Univ, Coll Sport Sci & Educ, Chongqing, Peoples R China.
C3 Southwest University - China; Huazhong University of Science &
   Technology; Southwest University - China
RP Zhou, ZQ (corresponding author), Southwest Univ, Coll Hort & Landscape Architecture, Chongqing, Peoples R China.; Zhou, ZQ (corresponding author), Chongqing Southwest Inst Fruits Nutr, Chongqing, Peoples R China.
EM zhouzhiqin@swu.edu.cn
FU Chongqing programme [2017-4-4]; National Risk Assessment Program for
   Agricultural Products Quality and Safety [GJFP201601501]; Fundamental
   Research Funds for the Central Universities [XDJK2017D087]
FX The work had its financial assistance from Chongqing programme to
   produce citrus fruit which mature lately (No. 2017-4-4); National Risk
   Assessment Program for Agricultural Products Quality and Safety
   (GJFP201601501); Fundamental Research Funds for the Central Universities
   (XDJK2017D087).
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NR 43
TC 2
Z9 2
U1 2
U2 14
PU CARBONE EDITORE
PI PALERMO
PA VIA QUINTINO SELLA, 68, PALERMO, 90139, ITALY
SN 0393-6384
EI 2283-9720
J9 ACTA MEDICA MEDITERR
JI Acta Medica Mediterr.
PY 2017
VL 33
IS 6
BP 1143
EP 1150
DI 10.19193/0393-6384_2017_6_179
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA FI4NW
UT WOS:000411949500038
DA 2025-06-11
ER

PT J
AU Calo, N
   Ramadori, P
   Sobolewski, C
   Romero, Y
   Maeder, C
   Fournier, M
   Rantakari, P
   Zhang, FP
   Poutanen, M
   Dufour, JF
   Humar, B
   Nef, S
   Foti, M
AF Calo, Nicolas
   Ramadori, Pierluigi
   Sobolewski, Cyril
   Romero, Yannick
   Maeder, Christine
   Fournier, Margot
   Rantakari, Pia
   Zhang, Fu-Ping
   Poutanen, Matti
   Dufour, Jean-Francois
   Humar, Bostjan
   Nef, Serge
   Foti, Michelangelo
TI Stress-activated miR-21/miR-21* in
   hepatocytes promotes lipid and glucose metabolic disorders associated
   with high-fat diet consumption
SO GUT
LA English
DT Article
ID HEPATOCELLULAR-CARCINOMA; INSULIN-RESISTANCE; DIABETES-MELLITUS;
   RECEPTOR-GAMMA; MICRORNA-21; EXPRESSION; LIVER; MIR-21; PHOSPHATASE;
   PATHWAY
AB Objective miR-21 is an oncomir highly upregulated in hepatocellular carcinoma and in early stages of liver diseases characterised by the presence of steatosis. Whether upregulation of miR-21 contributes to hepatic metabolic disorders and their progression towards cancer is unknown. This study aims at investigating the role of miR-21/miR-21* in early stages of metabolic liver disorders associated with diet-induced obesity (DIO).
   Design Constitutive miR-21/miR-21* knockout (miR21KO) and liver-specific miR-21/miR-21* knockout (LImiR21KO) mice were generated. Mice were then fed with high-fat diet (HFD) and alterations of the lipid and glucose metabolism were investigated. Serum and ex vivo explanted liver tissue were analysed.
   Results Under normal breeding conditions and standard diet, miR-21/miR-21* deletion in mice was not associated with any detectable phenotypic alterations. However, when mice were challenged with an obesogenic diet, glucose intolerance, steatosis and adiposity were improved in mice lacking miR-21/miR-21*. Deletion of miR-21/miR-21* specifically in hepatocytes led to similar improvements in mice fed an HFD, indicating a crucial role for hepatic miR-21/miR-21* in metabolic disorders associated with DIO. Further molecular analyses demonstrated that miR-21/miR-21* deletion in hepatocytes increases insulin sensitivity and modulates the expression of multiple key metabolic transcription factors involved in fatty acid uptake, de novo lipogenesis, gluconeogenesis and glucose output.
   Conclusions Hepatic miR-21/miR-21* deficiency prevents glucose intolerance and steatosis in mice fed an obesogenic diet by altering the expression of several master metabolic regulators. This study points out miR-21/miR-21* as a potential therapeutic target for nonalcoholic fatty liver disease and the metabolic syndrome.
C1 [Calo, Nicolas; Ramadori, Pierluigi; Sobolewski, Cyril; Maeder, Christine; Fournier, Margot; Foti, Michelangelo] Univ Geneva, Dept Cell Physiol & Metab, Geneva, Switzerland.
   [Romero, Yannick; Nef, Serge] Univ Geneva, Dept Genet Med & Dev, Fac Med, Geneva, Switzerland.
   [Rantakari, Pia] Univ Turku, MediCity Res Lab, Turku, Finland.
   [Rantakari, Pia; Zhang, Fu-Ping; Poutanen, Matti] Univ Turku, Dept Physiol, Turku, Finland.
   [Rantakari, Pia; Zhang, Fu-Ping; Poutanen, Matti] Univ Turku, Inst Biomed, Turku Ctr Dis Modeling, Turku, Finland.
   [Dufour, Jean-Francois] Univ Zurich Hosp, Dept Surg, Zurich, Switzerland.
   [Humar, Bostjan] Univ Bern, Dept Clin Res, Hepatol, Bern, Switzerland.
C3 University of Geneva; University of Geneva; University of Turku;
   University of Turku; University of Turku; University of Zurich;
   University Zurich Hospital; University of Bern
RP Foti, M (corresponding author), CMU, Dept Cell Physiol & Metab, 1 Rue Michel Servet, CH-1206 Geneva, Switzerland.
EM Michelangelo.foti@unige.ch
RI Dufour, Jean/AAL-9866-2020; Poutanen, Matti/I-1700-2018; Sobolewski,
   Cyril/ABA-8197-2021; Ramadori, Pierluigi/AAZ-7533-2021; Nef,
   Serge/AAV-6445-2020
OI Humar, Bostjan/0000-0002-7956-3062; Dufour,
   Jean-Francois/0000-0002-8062-1346; Nef, Serge/0000-0001-5462-0676;
   Ramadori, Pierluigi/0000-0001-6581-9648; Poutanen,
   Matti/0000-0002-8953-1734; Foti, Michelangelo/0000-0001-7199-4135;
   Rantakari, Pia/0000-0003-1638-5075; CALO, Nicolas/0000-0002-0897-4091;
   Sobolewski, Cyril/0000-0002-9404-6290
FU Swiss National Science Foundation [31003A 119862, 31003A 135227,
   310030-152618, CRSII3-141798, CRSII3-160717]; Bo & Kerstin Hjelt
   Foundation; EFSD Research Program in Diabetes and Cancer; Swiss Cancer
   league [KFS-02502-08-2009]; Swiss National Science Foundation (SNF)
   [CRSII3_141798, 310030_152618, 31003A_119862, 31003A_135227] Funding
   Source: Swiss National Science Foundation (SNF)
FX This work was supported by the Swiss National Science Foundation (grant
   No 31003A 119862 and 31003A 135227 to SN and No 310030-152618 and
   CRSII3-141798 and CRSII3-160717 to MF), The Bo & Kerstin Hjelt
   Foundation and the EFSD Research Program in Diabetes and Cancer and the
   Swiss Cancer league (KFS-02502-08-2009) to MF.
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NR 68
TC 101
Z9 107
U1 1
U2 28
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 0017-5749
EI 1468-3288
J9 GUT
JI Gut
PD NOV
PY 2016
VL 65
IS 11
BP 1871
EP 1881
DI 10.1136/gutjnl-2015-310822
PG 11
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA EA3AW
UT WOS:000386471000014
PM 27222533
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Sarma, R
   Kumari, S
   Elancheran, R
   Deori, M
   Devi, R
AF Sarma, Rahul
   Kumari, Sima
   Elancheran, Ramakrishnan
   Deori, Meetali
   Devi, Rajlakshmi
TI Polyphenol Rich Extract of Garcinia pedunculata Fruit
   Attenuates the Hyperlipidemia Induced by High Fat Diet
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Article
DE Garcinia pedunculata; polyphenol; antioxidant; hyperlipidemia; high-fat
   diet
ID LOW-DENSITY-LIPOPROTEIN; METABOLIC SYNDROME; OXIDATIVE STRESS; WISTAR
   RATS; RISK; ANTIOXIDANT; DISEASE; OBESITY; GUIDELINES; PLASMA
AB Fatty foods, the most common diet today are the crux of many metabolic disorders which need urgent attention. Garcinia pedunculata Roxb. (GP, Clusiaceae) is a plant found available in Northeast (NE) region of India, is considered to have versatile therapeutic properties. The people of this region has been using dried pulp of GP fruit for the treatment of different stomach related diseases traditionally. This study aimed at evaluating the potential therapeutic action of the polyphenol-rich methanolic extract of the fruit in experimental induced obese rats. In vitro antioxidant and antidiabetic activity of GP extracts, i.e., fruit extract (GF) and seed extract (GS) were determined by using various methods viz., 1,1-dipheny1-2 picrylhydrazyl (DPPH), 2,2'-Azinobis (3-ethyl benzthiazoline-6-sulphonic acid) (ABTS(center dot+)), nitroblue tetrazolium (NBT) and a-glucosidase inhibition assay for detection of antihyperglycemic activity. In vivo antilipidemic and antiobesity activities were evaluated by administrating oral dose of GF for 60 days on a high-fat diet (HFD) induced hyperlipidemia in the rat. GF showed higher antioxidant activity than GS by DPPH radical scavenging (IC50 = 4.01 mu g/ml), ABTS(center dot+)(IC50 = 0.82 mu g/ml), NBT (IC50 = 0.07 mu g/ml) and also showed notable alpha-glucosidase inhibitory activity (IC50 = 19.26 mu g/ml). Furthermore, GF treated rat revealed a reduction in the body weight (similar to 60%), serum total cholesterol (33%), triglycerides (32%), low-density lipoprotein (38%) and liver biomarker enzymes after 60 days HFD fed animals. Simultaneously, GF supplementation significantly protected the HFD induced changes in hematological parameters. Histological observations clearly differentiate the structural changes in liver of HFD and GF treated group. This novel dietary lipid adsorbing agent of GF exhibited prevention of hyperlipidemia induced by HFD in the rat.
C1 [Sarma, Rahul; Kumari, Sima; Devi, Rajlakshmi] Inst Adv Study Sci & Technol, Div Life Sci, Biochem Lab, Gauhati, India.
   [Elancheran, Ramakrishnan] Inst Adv Study Sci & Technol, Div Life Sci, Drug Discovery Lab, Gauhati, India.
   [Deori, Meetali] Nalbari Coll, Dept Zool, Nalbari, India.
C3 Department of Science & Technology (India); Institute of Advanced Study
   in Science & Technology (IASST); Department of Science & Technology
   (India); Institute of Advanced Study in Science & Technology (IASST)
RP Devi, R (corresponding author), Inst Adv Study Sci & Technol, Div Life Sci, Biochem Lab, Gauhati, India.
EM rajiasst@gmail.com
RI Ramakrishnan, Elancheran/P-5812-2015
OI Ramakrishnan, Elancheran/0000-0002-2819-5319
FU Department of Science and Technology, Govt. of India, New Delhi
FX Financial support for this study was obtained from Department of Science
   and Technology, Govt. of India, New Delhi.
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PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD AUG 31
PY 2016
VL 7
AR 294
DI 10.3389/fphar.2016.00294
PG 11
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA DU5ZX
UT WOS:000382293300002
PM 27642282
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Petrella, E
   Pignatti, L
   Neri, I
   Facchinetti, F
AF Petrella, Elisabetta
   Pignatti, Lucrezia
   Neri, Isabella
   Facchinetti, Fabio
TI The L-arginine/nitric oxide pathway is impaired in overweight/obese
   pregnant women
SO PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR
   HEALTH
LA English
DT Article
DE L-arginine; Endothelial function; Insulin; Pregnancy
ID ARTERY ENDOTHELIAL-CELLS; PULSATILE SHEAR-STRESS; NITRIC-OXIDE;
   INSULIN-RESISTANCE; SYNTHASE PHOSPHORYLATION; DEPENDENT VASODILATION;
   METABOLIC SYNDROME; ADIPOSE-TISSUE; DYSFUNCTION; MECHANISMS
AB Objective: To evaluate the L-arginine/NO system and its role in insulin signaling and endothelial function during the pregnancy of women of different BMI categories.
   Study design: Twelve women with BMI >= 25 were compared with 10 normal-weight women in a fasting condition after the infusion of L-arginine (20 g in 3 h) and after the evaluation of the flow-mediated vasodilation (FMD) of the brachial artery between the 9th-12th and 24th-27th weeks. Blood samples for insulin and nitrite/nitrate (NOx) were collected at baseline and after 1, 2 and 3 h after initiating the infusion.
   Results: In both trimesters, the baseline NOx levels were similar among groups. In the 1st trimester of the lean women, there was a NOx increase in response to L-Arg (AUC: 1328; 3, 3173), which had increased by the 2nd trimester (AUC: 3884; 1905, 7686); in overweight/obese women, no responses to L-Arg were found in the 1st or 2nd trimesters. In the 1st trimester, the insulin levels were significantly reduced in both groups after L-Arg infusion. Although the insulin levels in all BMI categories were higher in the 2nd trimester, such levels during weeks 24-27 were suppressed only in normal-weight women after L-Arg infusion. The FMD was higher during both trimesters in the lean controls and was impaired in the overweight/obese subjects.
   Conclusions: NO availability is impaired in overweight/obese women during pregnancy, which affects endothelial functioning and interferes with insulin regulation. These mechanisms could be involved in the development of hypertensive disorders and glucose intolerance in this population. (C) 2014 International Society for the Study of Hypertension in Pregnancy Published by Elsevier B.V. All rights reserved.
C1 [Petrella, Elisabetta; Pignatti, Lucrezia; Neri, Isabella; Facchinetti, Fabio] Univ Modena & Reggio Emilia, Mother Infant Dept, I-41124 Modena, Italy.
C3 Universita di Modena e Reggio Emilia
RP Facchinetti, F (corresponding author), Univ Modena & Reggio Emilia, Policlin Hosp, Mother Infant Dept, Via Pozzo 71, I-41124 Modena, Italy.
EM fabio.facchinetti@unimore.it
RI Facchinetti, Fabio/K-9929-2014; NERI, Isabella/P-4506-2016; Pignatti,
   Lucrezia/K-4101-2018
OI Petrella, Elisabetta/0000-0002-8306-8005; NERI,
   Isabella/0000-0003-4019-7373; Pignatti, Lucrezia/0000-0003-4911-5311
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NR 37
TC 8
Z9 9
U1 0
U2 3
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 2210-7789
J9 PREGNANCY HYPERTENS
JI Pregnancy Hypertens.
PD APR
PY 2014
VL 4
IS 2
BP 150
EP 155
DI 10.1016/j.preghy.2014.01.001
PG 6
WC Obstetrics & Gynecology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology; Cardiovascular System & Cardiology
GA CN1WO
UT WOS:000358211500004
PM 26104420
DA 2025-06-11
ER

PT J
AU Ching, RHH
   Yeung, LOY
   Tse, IMY
   Sit, WH
   Li, ETS
AF Ching, Rachel H. H.
   Yeung, Lilian O. Y.
   Tse, Iris M. Y.
   Sit, Wai-Hung
   Li, Edmund T. S.
TI Supplementation of Bitter Melon to Rats Fed a High-Fructose Diet During
   Gestation and Lactation Ameliorates Fructose-Induced Dyslipidemia and
   Hepatic Oxidative Stress in Male Offspring
SO JOURNAL OF NUTRITION
LA English
DT Article
ID GOURD MOMORDICA-CHARANTIA; INSULIN-RESISTANCE; PEROXISOME PROLIFERATOR;
   DEVELOPMENTAL ORIGINS; ACTIVATED RECEPTORS; LIPID-PEROXIDATION;
   METABOLIC SYNDROME; REDUCED ADIPOSITY; FATTY LIVER; RICH DIET
AB This study examined the impact of maternal high-fructose intake and if metabolic control in the offspring could benefit from supplementing bioactive food components such as bitter melon (BM) to the maternal diet. In Expt. 1, virgin female rats received control (C), high-fructose (F; 60%), or BM-supplemented fructose (FBM; 1%) diet before conception until d 21 of lactation. Weaned male offspring were fed the C diet for 11 wk, forming C/C, F/C, and FBM/C groups. The F/C group had elevated serum insulin, TG, and FFA concentrations and hepatic lipid alterations compared with the C/C and FBM/C groups (P<0.05). The 2 latter groups did not differ. Expt. 2 had similar dam treatment groups, but offspring were weaned to the C or F diet, forming C/C, C/F, F/F, and FBM/F groups, and the dietary treatment was extended to 20 wk. The hepatic levels of stearyl-CoA desaturase and microsomal TG transfer protein mRNA were lower, but that of PPAR gamma coactivator 1-alpha and fibroblast growth factor 21 mRNA and fatty acid binding protein 1 protein were higher in the FBM/F group compared with the C/F and F/F groups (P<0.05), indicating that maternal BM supplementation may reduce lipogenesis and promote lipid oxidation in offspring. The FBM/F group had significantly higher activities of liver glutathione peroxidase, superoxide dismutase, and catalase than the F/F group. The results indicate that supplementing BM to dams could offset the adverse effects of maternal high-fructose intake on lipid metabolism and antioxidant status in adult offspring. J. Nutr. 141: 1664-1672, 2011.
C1 [Ching, Rachel H. H.; Yeung, Lilian O. Y.; Tse, Iris M. Y.; Sit, Wai-Hung; Li, Edmund T. S.] Univ Hong Kong, Food & Nutr Sci Div, Sch Biol Sci, Hong Kong, Hong Kong, Peoples R China.
C3 University of Hong Kong
RP Li, ETS (corresponding author), Univ Hong Kong, Food & Nutr Sci Div, Sch Biol Sci, Hong Kong, Hong Kong, Peoples R China.
EM etsli@hku.hk
RI Li, Edmund/D-3101-2009
FU University of Hong Kong
FX Supported by Faculty Development Fund, The University of Hong Kong.
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NR 58
TC 48
Z9 53
U1 0
U2 11
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0022-3166
EI 1541-6100
J9 J NUTR
JI J. Nutr.
PD SEP
PY 2011
VL 141
IS 9
BP 1664
EP 1672
DI 10.3945/jn.111.142299
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 815KC
UT WOS:000294523500012
PM 21813810
OA Bronze
DA 2025-06-11
ER

PT J
AU Mochizuki, K
   Miyauchi, R
   Misaki, Y
   Shimada, M
   Kasezawa, T
   Tohyama, K
   Goda, T
AF Mochizuki, Kazuki
   Miyauchi, Rie
   Misaki, Yasumi
   Shimada, Masaya
   Kasezawa, Toshihiko
   Tohyama, Kazunari
   Goda, Toshinao
TI Accumulation of Visceral Fat Is Positively Associated with Serum ALT and
   γ-GTP Activities in Healthy and Preclinical Middle-Aged Japanese Men
SO JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY
LA English
DT Article
DE ALT; gamma-GTP; visceral fat; Japanese men; healthy and preclinical
   subjects
ID NF-KAPPA-B; ALANINE AMINOTRANSFERASE; METABOLIC SYNDROME;
   GLUTAMYL-TRANSFERASE; INSULIN-RESISTANCE; OXIDATIVE STRESS; REDOX
   REGULATION; ADIPOSE-TISSUE; LIVER-ENZYMES; RISK
AB Elevated circulating alanine aminotransferase (ALT) and gamma-glutamyltransferase (gamma-GTP) activities, and the accumulation of fat, particularly visceral fat, in healthy and preclinical subjects reportedly increase the risk for metabolic diseases such as diabetes. In the present study, we examined the associations between these hepatic enzymes and the total visceral and subcutaneous fat area, and for both regions of fat independently, in healthy and preclinical middle-aged Japanese men. We conducted a cross-sectional study of men who participated in health check-ups in Japan. We removed participants, who were diagnosed with metabolic diseases at the time of the health check-up. Three hundred fifteen subjects aged 40-64 y (mean +/- SD, 50.5 +/- 6.9 y) were selected. We compared associations between the total visceral and subcutaneous fat area, and for both regions independently, with various clinical parameters, including hepatic enzyme markers, using Spearman's rank correlation coefficient analysis and multiple linear regression analysis. The total visceral and subcutaneous fat area and both regions independently were positively associated with body mass index, systolic and diastolic blood pressure, fasting blood glucose, total cholesterol, low-density lipoprotein cholesterol, aspartate aminotransferase. ALT and gamma-GTP. Arr and gamma-GTP activities were the strongest explanatory variables for increased visceral fat area, independent of the subcutaneous fat area. In contrast, these hepatic enzymes were not explanatory variables for increased subcutaneous fat area. The results of the present study show that the accumulation of visceral fat is positively associated with ALT and gamma-GTP activities independently of subcutaneous fat area in healthy and preclinical Japanese men.
C1 [Mochizuki, Kazuki; Miyauchi, Rie; Misaki, Yasumi; Shimada, Masaya; Goda, Toshinao] Univ Shizuoka, Grad Sch Nutr & Environm Sci, Lab Nutr Physiol, Shizuoka 4228526, Japan.
   [Mochizuki, Kazuki; Miyauchi, Rie; Misaki, Yasumi; Shimada, Masaya; Goda, Toshinao] Univ Shizuoka, Grad Sch Nutr & Environm Sci, Global COB Program, Shizuoka 4228526, Japan.
   [Kasezawa, Toshihiko; Tohyama, Kazunari] Shizuoka Med Ctr, Shizuoka 4228670, Japan.
C3 University of Shizuoka; University of Shizuoka
RP Goda, T (corresponding author), Univ Shizuoka, Grad Sch Nutr & Environm Sci, Lab Nutr Physiol, Shizuoka 4228526, Japan.
EM gouda@u-shizuoka-ken.ac.jp
RI Goda, Toshinao/C-8981-2014
FU Ministry of Education, Culture, Sports, Science and Technology of Japan;
   Ministry of Health. Labour and Welfare of Japan
FX This study was financially supported by the Global COB program for the
   Center of Excellence for Innovation in Human Health Sciences from the
   Ministry of Education, Culture, Sports, Science and Technology of Japan,
   and a grant from the Ministry of Health. Labour and Welfare of Japan. We
   thank Drs. S. Sasaki and K. Murakami for providing the BDHQ and for
   helpful discussions.
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NR 27
TC 9
Z9 9
U1 0
U2 3
PU CENTER ACADEMIC PUBL JAPAN
PI TOKYO
PA 2-4-16 YAYOI, BUNKYO-KU, TOKYO, 113-0032, JAPAN
SN 0301-4800
EI 1881-7742
J9 J NUTR SCI VITAMINOL
JI J. Nutr. Sci. Vitaminol.
PD FEB
PY 2011
VL 57
IS 1
BP 65
EP 73
DI 10.3177/jnsv.57.65
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 733CD
UT WOS:000288237100010
PM 21512293
OA gold
DA 2025-06-11
ER

PT J
AU Afzali, A
   Weiss, NS
   Boyko, EJ
   Ioannou, GN
AF Afzali, Anita
   Weiss, Noel S.
   Boyko, Edward J.
   Ioannou, George N.
TI Association Between Serum Uric Acid Level and Chronic Liver Disease in
   the United States
SO HEPATOLOGY
LA English
DT Article
ID ALANINE AMINOTRANSFERASE ACTIVITY; CIRRHOSIS-RELATED DEATH;
   CARDIOVASCULAR RISK; HYPERURICEMIA; POPULATION; PREVALENCE;
   HOSPITALIZATION; CONSUMPTION; PREDICTORS; OBESITY
AB Elevated serum uric acid (UA) levels strongly reflect and may even cause oxidative stress, insulin resistance, and metabolic syndrome, which are risk factors for the progression of liver disease. We sought to determine whether serum UA levels are associated with the development of cirrhosis or the presence of elevated serum liver enzymes. We used cohort data from the first National Health and Nutrition Examination Survey (NHANES I) to determine whether the baseline serum UA level was associated with the incidence of hospitalization or death due to cirrhosis among 5518 participants during a mean follow-up of 12.9 years (range = 4-21 years) after the exclusion of the first 4 years of follow-up. We also used cross-sectional data from NHANES 1988-1994 (n = 10,993) and NHANES 19992006 (n = 6186) to determine whether the serum UA level was associated with elevated serum alanine aminotransferase (ALT) or gamma-glutamyl transferase (GGT), two markers of hepatic necroinflammation. Compared to persons in the lower third of the distribution of serum UA (<4.8 mg/dL), those in the top third (>6 mg/dL) had a higher risk of cirrhosis-related hospitalization or death [adjusted hazard ratio (AHR) = 2.8, 95% confidence interval (CI) =1.3-5.7], whereas the risk was not substantially increased in persons within the middle third (serum UA level = 2.6-4.8 mg/dL, AHR = 1.3, 95% CI = 0.6-2.7). A higher serum UA level was associated with greater mean serum ALT and GGT levels and a greater probability of elevated serum ALT and GGT. Conclusion: The serum UA level is associated with the development of cirrhosis and the presence of elevated serum liver enzymes after adjustments for important causes and risk factors of chronic liver disease. (HEPATOLOGY 2010;52:578-589)
C1 [Afzali, Anita; Ioannou, George N.] Vet Affairs Puget Sound Hlth Care Syst, Dept Med, Div Gastroenterol, Seattle, WA 98108 USA.
   [Afzali, Anita; Ioannou, George N.] Vet Affairs Puget Sound Hlth Care Syst, Res Enhancement Award Program, Seattle, WA 98108 USA.
   [Boyko, Edward J.] Vet Affairs Puget Sound Hlth Care Syst, Seattle Epidemiol Res & Informat Ctr, Seattle, WA 98108 USA.
   [Weiss, Noel S.] Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA.
   [Afzali, Anita; Ioannou, George N.] Univ Washington, Dept Med, Div Gastroenterol, Seattle, WA USA.
   [Boyko, Edward J.] Univ Washington, Dept Med, Div Internal Med, Seattle, WA USA.
C3 US Department of Veterans Affairs; Veterans Health Administration (VHA);
   Vet Affairs Puget Sound Health Care System; US Department of Veterans
   Affairs; Veterans Health Administration (VHA); Vet Affairs Puget Sound
   Health Care System; US Department of Veterans Affairs; Veterans Health
   Administration (VHA); Vet Affairs Puget Sound Health Care System;
   University of Washington; University of Washington Seattle; University
   of Washington; University of Washington Seattle; University of
   Washington; University of Washington Seattle
RP Ioannou, GN (corresponding author), Vet Affairs Puget Sound Hlth Care Syst, Dept Med, Div Gastroenterol, S-111 Gastro,1660 S Columbian Way, Seattle, WA 98108 USA.
EM georgei@medicine.washington.edu
RI Boyko, Edward/G-2484-2017
OI Boyko, Edward/0000-0002-3695-192X
FU NIDDK NIH HHS [P30 DK-17047] Funding Source: Medline
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   NHANES 1999 2000 LAB
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NR 27
TC 101
Z9 107
U1 1
U2 18
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0270-9139
EI 1527-3350
J9 HEPATOLOGY
JI Hepatology
PD AUG
PY 2010
VL 52
IS 2
BP 578
EP 589
DI 10.1002/hep.23717
PG 12
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 633OZ
UT WOS:000280513900020
PM 20683957
DA 2025-06-11
ER

PT J
AU Iwashima, Y
   Katsuya, T
   Ishikawa, K
   Kida, I
   Ohishi, M
   Horio, T
   Ouchi, N
   Ohashi, K
   Kihara, S
   Funahashi, T
   Rakugi, H
   Ogihara, T
AF Iwashima, Y
   Katsuya, T
   Ishikawa, K
   Kida, I
   Ohishi, M
   Horio, T
   Ouchi, N
   Ohashi, K
   Kihara, S
   Funahashi, T
   Rakugi, H
   Ogihara, T
TI Association of hypoadiponectinemia with smoking habit in men
SO HYPERTENSION
LA English
DT Article
DE smoking; oxidative stress; risk factors; lipids; lipoprotein; metabolism
ID HUMAN ADIPOSE-TISSUE; C-REACTIVE PROTEIN; CIGARETTE-SMOKING; PLASMA
   ADIPONECTIN; INSULIN-RESISTANCE; 3T3-L1 ADIPOCYTES; GENE-EXPRESSION;
   NICOTINE; RISK; RECEPTORS
AB Adiponectin is emerging as an important molecule in obesity, the metabolic syndrome, and cardiovascular disease. On the other hand, smoking habit is well known to be related to cardiovascular disease and hypertension. To examine the association between adiponectin concentration and smoking habit, we performed an epidemiological survey and an acute exposure test in humans and an experiment in adipocytes to elucidate the mechanism underlying the association between adiponectin and smoking. In the epidemiological study, we enrolled a total of 331 male subjects to examine chronic smoking exposure. Plasma adiponectin was significantly lower ( P = 0.01) in current smokers ( 5.3 +/- 0.3 mu g/mL) than in never-smokers (6.5 +/- 0.4 mu g/mL). A significant association between smoking and low adiponectin level was also confirmed in multiple regression analysis including age, body mass index, hypertension, diabetes, hyperlipidemia, and creatinine clearance ( never- smokers 6.5 +/- 0.4 mu g/mL; past smokers 5.6 +/- 0.3 mu g/mL; current smokers 5.2 +/- 0.4 mu g/mL; F = 4.52; P = 0.01). To examine the acute effect of smoking on adiponectin concentration for 12 hours, we measured plasma adiponectin level in 5 male never- smokers before smoking and 3, 6, and 12 hours after smoking, with the result that adiponectin showed a significant decrease after smoking ( 12 hours; - 14.5 +/- 0.6%; P < 0.01). In cultured mouse 3T3-L1 adipocytes, H2O2 and nicotine reduced the mRNA expression and secretion of adiponectin in a dose-dependent manner. Smoking habit is associated with adiponectin concentration in men, and its suppressive effect is mediated in part through direct inhibition of smoking on adiponectin expression in adipocytes.
C1 Osaka Univ, Grad Sch Med, Dept Geriatr Med, Suita, Osaka 5650871, Japan.
   Osaka Univ, Grad Sch Med, Dept Internal Med & Mol Sci, Suita, Osaka 5650871, Japan.
   Natl Cardiovasc Ctr, Dept Med, Div Nephrol & Hypertens, Osaka, Japan.
C3 The University of Osaka; The University of Osaka; National Cerebral &
   Cardiovascular Center - Japan
RP Osaka Univ, Grad Sch Med, Dept Geriatr Med, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan.
EM katsuya@geriat.med.osaka-u.ac.jp
RI Kastuya, Tomohiro/HLQ-5837-2023; Rakugi, Hiromi/ADM-3795-2022; OUCHI,
   Noriyuki/I-7306-2014
OI Rakugi, Hiromi/0000-0001-6508-4338
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NR 45
TC 113
Z9 124
U1 0
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0194-911X
EI 1524-4563
J9 HYPERTENSION
JI Hypertension
PD JUN
PY 2005
VL 45
IS 6
BP 1094
EP 1100
DI 10.1161/01.HYP.0000169444.05588.4c
PG 7
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 930DS
UT WOS:000229396600013
PM 15897361
OA Bronze
DA 2025-06-11
ER

PT J
AU Gonzalez, MA
   Selwyn, AP
AF Gonzalez, MA
   Selwyn, AP
TI Endothelial function, inflammation, and prognosis in cardiovascular
   disease
SO AMERICAN JOURNAL OF MEDICINE
LA English
DT Article
ID C-REACTIVE PROTEIN; NITRIC-OXIDE SYNTHASE; CELL-ADHESION MOLECULE-1;
   ACUTE CORONARY SYNDROMES; INSULIN-RESISTANCE; SMOOTH-MUSCLE;
   RISK-FACTORS; VASOMOTOR RESPONSE; DEPENDENT VASODILATION; OXIDATIVE
   STRESS
AB The vascular endothelium is an active, dynamic tissue that controls many important functions, including regulation of vascular tone and maintenance of blood circulation, fluidity, coagulation, and inflammatory responses. Cardiovascular risk factors affect many of the normal functions of the endothelium. In particular, oxidized low-density lipoprotein cholesterol initiates a series of events that begin with cell activation, endothelial dysfunction, local inflammation, and a procoagulant vascular surface. These conspire to result in plaque formation and ultimately plaque rupture and cardiovascular events.
   Endothelial dysfunction may be evaluated by means of invasive techniques, such as coronary artery reactivity to acetylcholine, or noninvasive techniques, such as brachial artery ultrasonography. Loss of endothelium-dependent vasodilation is a characteristic feature throughout the development of atherosclerosis, and it is independently related to future adverse cardiovascular risk. Therefore, measurement of endothelial function can possibly be used to determine risk, to triage management, and to improve outcomes. At the same time, inflammation is a crucial factor in the atherosclerotic disease process. To identify and monitor the ongoing inflammatory process, markers of inflammation such as C-reactive protein (CRP) have been studied. Scientific evidence shows that elevated plasma CRP values add to the predictive ability of other established risk factors; moreover, elevated values appear to augment the Framingham Coronary Risk Score in identifying individuals who should be considered for cardioprotective treatment programs.
   Interestingly, thiazolidinediones (TZDs), peroxisome proliferator-activated receptor-gamma agonists that are effective in the treatment of type 2 diabetes mellitus, not only increase insulin sensitivity but can benefit endothelial function because they exhibit anti-inflammatory effects. For many individuals, including those with the metabolic syndrome and/or type 2 diabetes, endothelial dysfunction and elevated plasma CRP levels indicate increased risk of cardiovascular disease. Notably, the TZDs have been shown to reduce CRP levels and may improve endothelial function. (C) 2003 by Excerpta Medica, Inc.
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C3 Harvard University; Harvard Medical School
RP Harvard Univ, Sch Med, Brigham & Womens Hosp, Div Cardiovasc, TR-3-13,75 Francis St, Boston, MA 02115 USA.
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NR 84
TC 194
Z9 215
U1 0
U2 9
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0002-9343
EI 1555-7162
J9 AM J MED
JI Am. J. Med.
PD DEC 8
PY 2003
VL 115
SU 8A
BP 99
EP 106
DI 10.1016/j.amjmed.2003.09.016
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 754JD
UT WOS:000187311800017
DA 2025-06-11
ER

PT J
AU Shekarchian, M
   Peeri, M
   Azarbayjani, MA
AF Shekarchian, Mandana
   Peeri, Maghsoud
   Azarbayjani, Mohammad Ali
TI Physical activity in a swimming pool attenuates memory impairment by
   reducing glutamate and inflammatory cytokines and increasing BDNF in the
   brain of mice with type 2 diabetes
SO BRAIN RESEARCH BULLETIN
LA English
DT Article
DE Physical activity; Metabolic syndrome; Memory; Cognition; Hippocampus;
   Mice
ID COGNITIVE IMPAIRMENT; INSULIN-RESISTANCE; NEUROTROPHIC FACTOR;
   ALZHEIMERS-DISEASE; NEURONAL DEATH; SPATIAL MEMORY; RECOGNITION MEMORY;
   GENDER-DIFFERENCES; PREFRONTAL CORTEX; OXIDATIVE STRESS
AB Type 2 diabetes is a risk factor for the development of cognitive impairment. Increasing evidence suggests that regular exercise is beneficial for the treatment of clinical symptoms in diabetic patients. The current study aimed to evaluate whether increasing physical activity through swimming training can reduce memory impairment in an animal model of type 2 diabetes. Diabetes and non-diabetes mice underwent swimming training for four weeks, and then working, spatial, and recognition memory were evaluated using three behavioral tests. Body weight, glucose, and insulin resistance were monitored. We also measured inflammatory cytokines (interleukin (IL)- 6, IL-1 & beta;, and tumor-necrosis-factor (TNF)-& alpha;), an anti-inflammatory cytokine (IL-10), and brain-derivedneurotrophic-factor (BDNF), and glutamate levels in the hippocampus or prefrontal cortex of mice. The findings showed that diabetes increased body weight, glucose, and insulin resistance, impaired working, spatial and recognition memory, increased levels of IL-6, IL-1 & beta;, TNF-& alpha;, and glutamate levels, and decreased BDNF in the hippocampus of diabetic mice. While higher physical activity was associated with reduced body weight, glucose, and insulin resistance, attenuated memory impairment, IL-6, IL-1 & beta;, TNF-& alpha;, and glutamate, and increased BDNF levels in the hippocampus and prefrontal cortex of diabetic mice. This study shows that swimming training can normalize body weight and glucose-insulin axis and reduce inflammation and glutamate in the hippocampus and enhance the neurotrophic system in both the hippocampus and prefrontal cortex of diabetic mice. This study also suggests that higher physical activity through swimming training can improve cognitive impairment in a mouse model of type 2 diabetes.
C1 [Shekarchian, Mandana; Peeri, Maghsoud; Azarbayjani, Mohammad Ali] Islamic Azad Univ, Dept Exercise Physiol, Cent Tehran Branch, Tehran, Iran.
C3 Islamic Azad University
RP Peeri, M (corresponding author), Islamic Azad Univ, Dept Exercise Physiol, Cent Tehran Branch, Tehran, Iran.
EM m.peeri@iauctb.ac.ir
RI Peeri, Maghsoud/AAZ-6327-2021
OI Peeri, Maghsoud/0000-0003-1415-7319
FU Salari Institute of Cognitive and Behavioral Disorders (SICBD)
FX The authors would like to thank the "Salari Institute of Cognitive and
   Behavioral Disorders (SICBD) ' for its valuable support with animal
   models, behavioral experiments, and English editing service.
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NR 152
TC 4
Z9 4
U1 2
U2 7
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0361-9230
EI 1873-2747
J9 BRAIN RES BULL
JI Brain Res. Bull.
PD SEP
PY 2023
VL 201
AR 110725
DI 10.1016/j.brainresbull.2023.110725
EA AUG 2023
PG 14
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA Q1FD4
UT WOS:001055034800001
PM 37543294
OA hybrid
DA 2025-06-11
ER

PT J
AU Guo, NL
   Poh, TY
   Pirela, S
   Farcas, MT
   Chotirmall, SH
   Tham, WK
   Adav, SS
   Ye, Q
   Wei, YY
   Shen, SP
   Christiani, DC
   Ng, KW
   Thomas, T
   Qian, Y
   Demokritou, P
AF Guo, Nancy Lan
   Poh, Tuang Yeow
   Pirela, Sandra
   Farcas, Mariana T.
   Chotirmall, Sanjay H.
   Tham, Wai Kin
   Adav, Sunil S.
   Ye, Qing
   Wei, Yongyue
   Shen, Sipeng
   Christiani, David C.
   Ng, Kee Woei
   Thomas, Treye
   Qian, Yong
   Demokritou, Philip
TI Integrated Transcriptomics, Metabolomics, and Lipidomics Profiling in
   Rat Lung, Blood, and Serum for Assessment of Laser Printer-Emitted
   Nanoparticle Inhalation Exposure-Induced Disease Risks
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE printer emitted nanoparticles; inhalation; transcriptomics;
   metabolomics; lipidomics; biomarkers; nanotoxicity
ID AIRWAY EPITHELIAL-CELLS; IN-VITRO; ENGINEERED NANOPARTICLES; OXIDATIVE
   STRESS; TOXICOLOGICAL CHARACTERIZATION; THERMAL-DECOMPOSITION;
   MESSENGER-RNAS; TERM EXPOSURE; HISTIDINE; POLLUTION
AB Laser printer-emitted nanoparticles (PEPs) generated from toners during printing represent one of the most common types of life cycle released particulate matter from nano-enabled products. Toxicological assessment of PEPs is therefore important for occupational and consumer health protection. Our group recently reported exposure to PEPs induces adverse cardiovascular responses including hypertension and arrythmia via monitoring left ventricular pressure and electrocardiogram in rats. This study employed genome-wide mRNA and miRNA profiling in rat lung and blood integrated with metabolomics and lipidomics profiling in rat serum to identify biomarkers for assessing PEPs-induced disease risks. Whole-body inhalation of PEPs perturbed transcriptional activities associated with cardiovascular dysfunction, metabolic syndrome, and neural disorders at every observed time point in both rat lung and blood during the 21 days of exposure. Furthermore, the systematic analysis revealed PEPs-induced transcriptomic changes linking to other disease risks in rats, including diabetes, congenital defects, auto-recessive disorders, physical deformation, and carcinogenesis. The results were also confirmed with global metabolomics profiling in rat serum. Among the validated metabolites and lipids, linoleic acid, arachidonic acid, docosahexanoic acid, and histidine showed significant variation in PEPs-exposed rat serum. Overall, the identified PEPs-induced dysregulated genes, molecular pathways and functions, and miRNA-mediated transcriptional activities provide important insights into the disease mechanisms. The discovered important mRNAs, miRNAs, lipids and metabolites may serve as candidate biomarkers for future occupational and medical surveillance studies. To the best of our knowledge, this is the first study systematically integrating in vivo, transcriptomics, metabolomics, and lipidomics to assess PEPs inhalation exposure-induced disease risks using a rat model.
C1 [Guo, Nancy Lan; Ye, Qing] West Virginia Univ, Sch Publ Hlth, Inst Canc, Morgantown, WV 26506 USA.
   [Poh, Tuang Yeow; Chotirmall, Sanjay H.; Shen, Sipeng; Christiani, David C.] Nanyang Technol Univ, Lee Kong Chian Sch Med, Singapore 308232, Singapore.
   [Pirela, Sandra; Ng, Kee Woei; Demokritou, Philip] Harvard Univ, TH Chan Sch Publ Hlth, Dept Environm Hlth, Ctr Nanotechnol & Nanotoxicol, Boston, MA 02115 USA.
   [Farcas, Mariana T.; Qian, Yong] Natl Inst Occupat Safety & Hlth, Pathol & Physiol Res Branch, Hlth Effects Lab Div, Morgantown, WV 26505 USA.
   [Tham, Wai Kin; Adav, Sunil S.] Nanyang Technol Univ, Singapore Phenome Ctr, Lee Kong Chian Sch Med, Singapore 636921, Singapore.
   [Wei, Yongyue] Nanjing Med Univ, Key Lab Modern Toxicol, Dept Epidemiol & Biostat, Nanjing 210029, Peoples R China.
   [Wei, Yongyue] Nanjing Med Univ, Minist Educ MOE, Sch Publ Hlth, Nanjing 210029, Peoples R China.
   [Ng, Kee Woei] Nanyang Technol Univ, Sch Mat Sci & Engn, Singapore 639798, Singapore.
   [Ng, Kee Woei] Nanyang Environm & Water Res Inst, Environm Chem & Mat Ctr, Singapore 637141, Singapore.
   [Thomas, Treye] US Consumer Product Safety Commiss, Off Hazard Identificat & Reduct, Rockville, MD 20814 USA.
C3 West Virginia University; Nanyang Technological University; Harvard
   University; Harvard T.H. Chan School of Public Health; Centers for
   Disease Control & Prevention - USA; National Institute for Occupational
   Safety & Health (NIOSH); Nanyang Technological University; Nanjing
   Medical University; Nanjing Medical University; Ministry of Education -
   China; Nanyang Technological University; Nanyang Technological
   University
RP Guo, NL (corresponding author), West Virginia Univ, Sch Publ Hlth, Inst Canc, Morgantown, WV 26506 USA.
EM lguo@hsc.wvu.edu; poh_tuang_yeow@ntu.edu.sg; svp097@mail.harvard.edu;
   woe7@cdc.gov; schotirmall@ntu.edu.sg; tham_wk@ntu.edu.sg;
   ssadav@ntu.edu.sg; qiye@mix.wvu.edu; ywei@njmu.edu.cn;
   sshen@hsph.harvard.edu; dchris@hsph.harvard.edu; kwng@ntu.edu.sg;
   tthomas@cpsc.gov; yaq2@cdc.gov; pdemokri@hsph.harvard.edu
RI Demokritou, Philip/KFS-7813-2024; Adav, Sunil/ABG-4121-2021; Farcas,
   Mariana/LGZ-5266-2024; Wei, Yongyue/GYV-5660-2022; Ng, Kee
   Woei/JAN-7151-2023; Ye, Qing/GXF-0880-2022; Chotirmall, Sanjay
   Haresh/K-4127-2015; Ng, Kee Woei/B-7242-2008
OI Farcas, Mariana/0000-0003-2404-9434; Chotirmall, Sanjay
   Haresh/0000-0003-0417-7607; Adav, Sunil S/0000-0002-8559-4885; Ng, Kee
   Woei/0000-0002-7276-3563; Wei, Yongyue/0000-0002-1132-1796; Guo,
   Nancy/0000-0002-8050-6268
FU National Institute for Occupational Safety and Health; Consumer
   Protection Safety Commission [1007514R]; NTU-Harvard School of Public
   Health Initiative for Sustainable Nanotechnology [NTU-HSPH 17001]
FX This work is supported by the National Institute for Occupational Safety
   and Health and the Consumer Protection Safety Commission (1007514R). The
   metabolomics work was supported by the NTU-Harvard School of Public
   Health Initiative for Sustainable Nanotechnology (NTU-HSPH 17001).
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NR 90
TC 26
Z9 26
U1 7
U2 45
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD DEC
PY 2019
VL 20
IS 24
AR 6348
DI 10.3390/ijms20246348
PG 32
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA KB9XE
UT WOS:000506840100241
PM 31888290
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Parlapani, E
   Agakidis, C
   Karagiozoglou-Lampoudi, T
   Sarafidis, K
   Agakidou, E
   Athanasiadis, A
   Diamanti, E
AF Parlapani, Elisavet
   Agakidis, Charalampos
   Karagiozoglou-Lampoudi, Thomais
   Sarafidis, Kosmas
   Agakidou, Eleni
   Athanasiadis, Apostolos
   Diamanti, Elisavet
TI The Mediterranean diet adherence by pregnant women delivering
   prematurely: association with size at birth and complications of
   prematurity
SO JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
LA English
DT Article
DE Bronchopulmonary dysplasia; necrotizing enterocolitis; respiratory
   distress syndrome; retinopathy of prematurity
ID AGGRESSIVE POSTERIOR RETINOPATHY; OXIDATIVE STRESS; PRETERM BIRTH;
   NECROTIZING ENTEROCOLITIS; RISK-FACTOR; BRONCHOPULMONARY DYSPLASIA;
   FETAL-GROWTH; FATTY-ACIDS; CHORIOAMNIONITIS; INFLAMMATION
AB Background: The Mediterranean diet (MD) is associated with decreased risk of metabolic syndrome and gestational diabetes due to the anti-inflammatory and antioxidative properties of its components. The aim was to investigate the potential association of MD adherence (MDA) during pregnancy by mothers delivering prematurely, with intrauterine growth as expressed by neonates' anthropometry at birth and complications of prematurity. Participants and methods: This is a single-center, prospective, observational cohort study of 82 women who delivered preterm singletons at post conceptional age (PCA) <= 34 weeks and their live-born neonates. Maternal and neonatal demographic and clinical data were recorded. All mothers filled in a food frequency questionnaire, and the MDA score was calculated. Based on 50th centile of MD score, participants were classified into high-MDA and low-MDA groups. Results: The low-MDA mothers had significantly higher pregestational BMI and rates of overweight/obesity (odd ratios (OR) 3.5) and gestational hypertension/preeclampsia (OR 3.8). Neonates in the low-MDA group had significantly higher incidence of intrauterine growth restriction (IUGR) (OR 3.3) and lower z-scores of birth weight and BMI. Regarding prematurity-related complications, the low MDA-group was more likely to develop necrotizing enterocolitis, bronchopulmonary dysplasia, and retinopathy of prematurity (OR 3.2, 1.3, and 1.6, respectively), while they were less likely to develop respiratory distress syndrome (OR 0.49), although the differences were not statistically significant. However, adjustment for confounders revealed MDA as a significant independent predictor of hypertension/preeclampsia, IUGR, birth weight z-score, necrotizing enterocolitis, and bronchopulmonary dysplasia. Conclusions: High MDA during pregnancy may favorably affect intrauterine growth and certain acute and chronic complications of prematurity as well as maternal hypertension/preeclampsia.
C1 [Parlapani, Elisavet; Agakidis, Charalampos; Sarafidis, Kosmas; Agakidou, Eleni; Diamanti, Elisavet] Aristotle Univ Thessaloniki, Ippokrate Hosp, Dept Neonatol 1, Thessaloniki, Greece.
   [Parlapani, Elisavet; Agakidis, Charalampos; Sarafidis, Kosmas; Agakidou, Eleni; Diamanti, Elisavet] Aristotle Univ Thessaloniki, Ippokrate Hosp, Fac Med, NICU,Nutr Dietet Dept, Thessaloniki, Greece.
   [Parlapani, Elisavet; Karagiozoglou-Lampoudi, Thomais] Technol Educ Inst Thessaloniki, Clin Nutr Lab, Thessaloniki, Greece.
   [Agakidis, Charalampos] Aristotle Univ Thessaloniki, Ippokrate Hosp, Fac Med, Dept Pediat 1, Thessaloniki, Greece.
   [Athanasiadis, Apostolos] Aristotle Univ Thessaloniki, Ippokrate Hosp, Fac Med, Dept Obstet & Gynecol 3, Thessaloniki, Greece.
C3 Aristotle University of Thessaloniki; Aristotle University of
   Thessaloniki; International Hellenic University; Aristotle University of
   Thessaloniki; Aristotle University of Thessaloniki
RP Karagiozoglou-Lampoudi, T (corresponding author), Technol Educ Inst Thessaloniki, Clin Nutr Lab, Thessaloniki, Greece.
EM thomaiskl@hotmail.com
RI Diamanti, Elisavet/ABE-4764-2021; Sarafidis, Kosmas/R-1266-2019;
   AGAKIDIS, CHARALAMPOS/GXZ-7865-2022
OI Sarafidis, Kosmas/0000-0002-6806-6343; AGAKIDIS,
   CHARALAMPOS/0000-0002-2800-6530
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NR 49
TC 31
Z9 32
U1 0
U2 38
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1476-7058
EI 1476-4954
J9 J MATERN-FETAL NEO M
JI J. Matern.-Fetal Neonatal Med.
PD APR 3
PY 2019
VL 32
IS 7
BP 1084
EP 1091
DI 10.1080/14767058.2017.1399120
PG 8
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA HG8CC
UT WOS:000455223500006
PM 29082786
DA 2025-06-11
ER

PT J
AU Xiao, LL
   Zhou, Y
   Ma, JX
   Cao, LM
   Wang, B
   Zhu, CM
   Yang, SJ
   Li, W
   Zhang, Z
   Wang, DM
   Guo, YJ
   Mu, G
   Yuan, J
   Chen, WH
AF Xiao, Lili
   Zhou, Yun
   Ma, Jixuan
   Cao, Limin
   Wang, Bin
   Zhu, Chunmei
   Yang, Shijie
   Li, Wei
   Zhang, Zhuang
   Wang, Dongming
   Guo, Yanjun
   Mu, Ge
   Yuan, Jing
   Chen, Weihong
TI The cross-sectional and longitudinal associations of chromium with
   dyslipidemia: A prospective cohort study of urban adults in China
SO CHEMOSPHERE
LA English
DT Article
DE Urinary chromium; Repeated measures; Lipid profiles; Dyslipidemia;
   Cohort study
ID METABOLIC SYNDROME; OXIDATIVE STRESS; LIPID-METABOLISM; EXPOSURE;
   GLUCOSE; OBESE; SUPPLEMENTATION; ELEMENTS
AB Chromium exposure can induce altered lipoprotein metabolism in animals, but the health effects of chromium on dyslipidemia in humans have not been fully evaluated. In this study, we aimed to investigate the cross-sectional and longitudinal effects of urinary chromium on lipid levels and dyslipidemia risk among urban adults from two cities in China. A total of 3762 urban adults from the Wuhan-Zhuhai cohort were included in the initial investigation, and followed up three years later. Urinary chromium concentration was measured at baseline and repeated at follow-up. Associations of urinary chromium concentration with lipid levels and risk of dyslipidemia were analyzed by generalized linear and binary logistic regression models, respectively. We found significant relationships between increased urinary chromium concentration and both reduced triglyceride (TG) level and elevated high-density lipoprotein cholesterol (HDL-C) level at baseline and follow-up. In the cross-sectional analysis, each 1-unit increase in log-transformed urinary chromium was associated with a 0.25 mmol/L decrease in TG and a 0.05 mmol/L increase in HDL-C (P<0.05): also, downward trends for odds ratios of hyperTG (TG level >= 1.7 mmol/L) and hypoHDL-C (HDL-C level < 1.0 mmol/L) were significantly associated with increasing quartiles of urinary chromium (P trend < 0.05). In the longitudinal analysis, each 1-unit increase in log-transformed urinary chromium concentration was associated with a 3% and 6% decrease in the risk of developing hyperTG and hypoHDL-C, respectively (P> 0.05). Our study indicated that significant dose-response relationships between urinary chromium concentration and lipid levels were observed at baseline and at follow-up. (C) 2018 Elsevier Ltd. All rights reserved.
C1 [Xiao, Lili; Zhou, Yun; Ma, Jixuan; Cao, Limin; Wang, Bin; Zhu, Chunmei; Yang, Shijie; Li, Wei; Zhang, Zhuang; Wang, Dongming; Guo, Yanjun; Mu, Ge; Yuan, Jing; Chen, Weihong] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Dept Occupat & Environm Hlth, Wuhan 430030, Hubei, Peoples R China.
   [Xiao, Lili; Zhou, Yun; Ma, Jixuan; Cao, Limin; Wang, Bin; Zhu, Chunmei; Yang, Shijie; Li, Wei; Zhang, Zhuang; Wang, Dongming; Guo, Yanjun; Mu, Ge; Yuan, Jing; Chen, Weihong] Huazhong Univ Sci & Technol, Minist Educ, Key Lab Environm & Hlth, Wuhan 430030, Hubei, Peoples R China.
   [Xiao, Lili; Zhou, Yun; Ma, Jixuan; Cao, Limin; Wang, Bin; Zhu, Chunmei; Yang, Shijie; Li, Wei; Zhang, Zhuang; Wang, Dongming; Guo, Yanjun; Mu, Ge; Yuan, Jing; Chen, Weihong] Huazhong Univ Sci & Technol, Minist Environm Protect, Wuhan 430030, Hubei, Peoples R China.
   [Xiao, Lili; Zhou, Yun; Ma, Jixuan; Cao, Limin; Wang, Bin; Zhu, Chunmei; Yang, Shijie; Li, Wei; Zhang, Zhuang; Wang, Dongming; Guo, Yanjun; Mu, Ge; Yuan, Jing; Chen, Weihong] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, State Key Lab Environm Hlth Incubating, Wuhan 430030, Hubei, Peoples R China.
C3 Huazhong University of Science & Technology; Ministry of Education -
   China; Huazhong University of Science & Technology; Huazhong University
   of Science & Technology; Huazhong University of Science & Technology
RP Chen, WH (corresponding author), Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Dept Occupat & Environm Hlth, Wuhan 430030, Hubei, Peoples R China.
EM wchen@mails.tjmu.edu.cn
RI Chen, Weihong/D-2177-2011; /CAE-0251-2022; Mu, Ge/JXX-0910-2024
OI , Jixuan Ma/0000-0003-0644-0157; Wang, Bin/0000-0002-7166-0482
FU National key research and development program of China [2016YFC1303903];
   Key Program of the National Natural Science Foundation of China
   [91543207]; Fundamental Research Funds for the Central Universities
   [HUST 2016JCTD116, 2016YXZD044]
FX This study was funded by the National key research and development
   program of China (2016YFC1303903); the Key Program of the National
   Natural Science Foundation of China (91543207); and the Fundamental
   Research Funds for the Central Universities, HUST 2016JCTD116 and
   2016YXZD044.
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NR 43
TC 24
Z9 24
U1 1
U2 18
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0045-6535
EI 1879-1298
J9 CHEMOSPHERE
JI Chemosphere
PD JAN
PY 2019
VL 215
BP 362
EP 369
DI 10.1016/j.chemosphere.2018.10.060
PG 8
WC Environmental Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology
GA HA6IO
UT WOS:000450383400040
PM 30336313
DA 2025-06-11
ER

PT J
AU Li, X
   Zhu, ZX
   Zhou, TH
   Cao, XY
   Lu, T
   Liang, Y
   He, JF
   Liu, CK
   Dou, ZL
   Shen, B
AF Li, Xing
   Zhu, Zexiang
   Zhou, Tinghong
   Cao, Xiaoyu
   Lu, Ting
   Liang, Yan
   He, Jiafen
   Liu, Chuankai
   Dou, Zhoulin
   Shen, Bin
TI Early increases in serum FGF21 levels predict mortality of septic
   patients
SO CYTOKINE
LA English
DT Article
DE Fibroblast growth factor 21; Sepsis; Prognosis; Biomarkers
ID GROWTH-FACTOR 21; METABOLIC SYNDROME; BODY-COMPOSITION; SEPSIS; STRESS;
   ASSOCIATION; EXPRESSION; FACTOR-21; PROTECTS; OBESITY
AB Background: Potential prognostic biomarkers for patients with sepsis have yet to be identified. The present study evaluated the prognostic value of fibroblast growth factor 21 (FGF21) levels in patients with sepsis.
   Methods: A total of 120 consecutive Chinese patients with sepsis were prospectively included, and serum levels of FGF21 and biomarkers such as interleukin (IL)-6, tumor necrosis factor alpha (TNF-alpha), IL-10, procalcitonin (PCT), C-reactive protein (CRP), and lactate (LAC) were measured within 24 h after intensive care unit admission. The demographic and clinical characteristics including underlying diseases, Sequential Organ Failure Assessment (Delta SOFA), and acute physiology and chronic health evaluation II (APACHE II) scores were recorded. Patients were categorized into survival and non-survival groups according to the 28-day mortality. Correlations between FGF21, serum indicators, severity score and 28-day mortality were analyzed, and Cox regression analysis was performed to identify prognostic factors. Receiver operating characteristic (ROC) curve analysis was used to determine the optimal cut-off of FGF21 for survival prediction.
   Results: Non-survivors had significantly higher levels of FGF21, IL-6, TNF-alpha, IL-10, PCT, CRP, and LAC as well as higher SOFA and APACHE II scores compared with the survivors. FGF21 levels were positively correlated with age, waist circumference, levels of IL-6, IL-10, TNF-alpha, PCT, CRP, and LAC, Delta SOFA and APACHE II scores. ROC curves showed that FGF21 had a high sensitivity of 81.3% and specificity of 89.8% for predicting 28-day mortality. Patients with a FGF21 levels < 3200 pg/ml had a significantly better survival rate than those with levels > 3200 pg/ml, and thus, FGF21 was an independent prognostic factor for survival.
   Conclusion: FGF21 could serve as a new prognostic biomarker for sepsis survival.
C1 [Li, Xing; Zhu, Zexiang; Zhou, Tinghong; Cao, Xiaoyu; Lu, Ting; Liang, Yan; He, Jiafen; Liu, Chuankai; Dou, Zhoulin; Shen, Bin] Changsha Tradit Chinese Med Hosp, Dept Crit Care Med, 22 Xingsha Rd, Changsha 410010, Hunan, Peoples R China.
RP Zhu, ZX (corresponding author), Changsha Tradit Chinese Med Hosp, Dept Crit Care Med, 22 Xingsha Rd, Changsha 410010, Hunan, Peoples R China.
EM zhuzexiang12@163.com
RI Cao, Xiaoyu/LRT-9172-2024
OI Lu, Ting/0000-0002-1611-9909
FU Scientific Research of Health and Family Planning Commission of Hunan
   Province [2015-71]
FX The project was supported by Scientific Research of Health and Family
   Planning Commission of Hunan Province in 2015, 2015-71.
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NR 26
TC 22
Z9 24
U1 0
U2 9
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 1043-4666
EI 1096-0023
J9 CYTOKINE
JI Cytokine
PD NOV
PY 2018
VL 111
BP 428
EP 433
DI 10.1016/j.cyto.2018.05.020
PG 6
WC Biochemistry & Molecular Biology; Cell Biology; Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology; Immunology
GA HG1XG
UT WOS:000454753800057
PM 29861384
DA 2025-06-11
ER

PT J
AU Gonzalez-Vicente, A
   Hong, NJ
   Yang, N
   Cabral, PD
   Berthiaume, JM
   Dominici, FP
   Garvin, JL
AF Gonzalez-Vicente, Agustin
   Hong, Nancy J.
   Yang, Nianxin
   Cabral, Pablo D.
   Berthiaume, Jessica M.
   Dominici, Fernando P.
   Garvin, Jeffrey L.
TI Dietary Fructose Increases the Sensitivity of Proximal Tubules to
   Angiotensin II in Rats Fed High-Salt Diets
SO NUTRIENTS
LA English
DT Article
DE kidney; blood pressure; salt sensitivity; Na+; H+ exchange; Na+;
   K+-ATPase; atrial natriuretic peptide; norepinephrine; sodium excretion
ID ATRIAL-NATRIURETIC-FACTOR; INDUCED METABOLIC SYNDROME; BLOOD-PRESSURE;
   INSULIN-RESISTANCE; INDUCED HYPERTENSION; SWEETENED BEVERAGES; OXIDATIVE
   STRESS; NITRIC-OXIDE; PEPTIDE; MECHANISMS
AB Dietary fructose causes salt-sensitive hypertension. Proximal tubules (PTs) reabsorb 70% of the filtered NaCl. Angiotensin II (Ang II), atrial natriuretic peptide (ANP) and norepinephrine (NE) regulate this process. Although Ang II signaling blockade ameliorates fructose-induced salt-sensitive hypertension, basal PT Na+ reabsorption and its sensitivity to the aforementioned factors have not been studied in this model. We hypothesized consuming fructose with a high-salt diet selectively enhances the sensitivity of PT transport to Ang II. We investigated the effects of Ang II, ANP and NE on PT Na reabsorption in rats fed a high-salt diet drinking tap water (HS) or 20% fructose (HS-FRU). Oxygen consumption (QO(2)) was used as a measure of all ATP-dependent transport processes. Na+/K+-ATPase and Na+/H+-exchange (NHE) activities were studied because they represent primary apical and basolateral transporters in this segment. The effect of 10(-12) mol/L Ang II in QO(2) by PTs from HS-FRU was larger than HS (p < 0.02; n = 7). In PTs from HS-FRU 10(-12) mol/L Ang II stimulated NHE activity by 2.6 +/- 0.7 arbitrary fluorescence units/s (p < 0.01; n = 5) but not in those from HS. The stimulatory effect of Ang II on PT Na+/K+-ATPase activity was not affected by HS-FRU. Responses of QO(2) and NHE activity to ANP did not differ between groups. The response of QO(2) to NE was unaltered by HS-FRU. We concluded that the sensitivity of PT Na+ reabsorption specifically to Ang II is enhanced by HS-FRU. This maintains high rates of transport even in the presence of low concentrations of the peptide, and likely contributes to the hypertension.
C1 [Gonzalez-Vicente, Agustin; Hong, Nancy J.; Yang, Nianxin; Cabral, Pablo D.; Berthiaume, Jessica M.; Garvin, Jeffrey L.] Case Western Reserve Univ, Sch Med, Dept Physiol & Biophys, Cleveland, OH 44106 USA.
   [Gonzalez-Vicente, Agustin; Dominici, Fernando P.] Univ Buenos Aires, Fac Farm & Bioquim, C1113AAD, Buenos Aires, DF, Argentina.
   [Cabral, Pablo D.] Univ Buenos Aires, Dept Ciencias Fisiol, Fac Med, C1121ABG, Buenos Aires, DF, Argentina.
   [Cabral, Pablo D.] Merk Res Labs, 630 Gateway Blvd, San Francisco, CA 94080 USA.
   [Dominici, Fernando P.] Consejo Nacl Invest Cient & Tecn, Consejo Nacl Invest Cient & Tecn, Inst Quim & Fisicoquim Biol, C1113AAD, Buenos Aires, DF, Argentina.
C3 University System of Ohio; Case Western Reserve University; University
   of Buenos Aires; University of Buenos Aires; Consejo Nacional de
   Investigaciones Cientificas y Tecnicas (CONICET)
RP Gonzalez-Vicente, A (corresponding author), Case Western Reserve Univ, Sch Med, Dept Physiol & Biophys, Cleveland, OH 44106 USA.; Gonzalez-Vicente, A (corresponding author), Univ Buenos Aires, Fac Farm & Bioquim, C1113AAD, Buenos Aires, DF, Argentina.
EM agustin.gonzalezvicente@case.edu; nxh156@case.edu; nxy66@case.edu;
   pdcabral@gmail.com; jessica.berthiaume@case.edu;
   dominici@qb.ffyb.uba.ar; jlg5@case.edu
RI ; Gonzalez-Vicente, Agustin/K-2773-2018
OI Yang, Nianxin/0000-0002-6842-7874; Gonzalez-Vicente,
   Agustin/0000-0002-3682-0815; Dominici, Fernando
   Pablo/0000-0002-4351-0057
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NR 69
TC 21
Z9 24
U1 0
U2 1
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD SEP
PY 2018
VL 10
IS 9
AR 1244
DI 10.3390/nu10091244
PG 16
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA GY5YI
UT WOS:000448659900117
PM 30200571
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Cheung, YT
   Edelmann, MN
   Mulrooney, DA
   Green, DM
   Chemaitilly, W
   John, N
   Robison, LL
   Hudson, MM
   Krull, KR
AF Cheung, Yin Ting
   Edelmann, Michelle N.
   Mulrooney, Daniel A.
   Green, Daniel M.
   Chemaitilly, Wassim
   John, Neena
   Robison, Leslie L.
   Hudson, Melissa M.
   Krull, Kevin R.
TI Uric Acid and Neurocognitive Function in Survivors of Childhood Acute
   Lymphoblastic Leukemia Treated with Chemotherapy Only
SO CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
LA English
DT Article
ID COGNITIVE FUNCTION; METABOLIC SYNDROME; INFLAMMATORY CYTOKINES;
   EXECUTIVE FUNCTION; OXIDATIVE STRESS; CANCER SURVIVOR; CHILDREN;
   HYPERURICEMIA; HOMOCYSTEINE; THERAPY
AB Background: Hyperuricemia is implicated in cardiovascular and cerebrovascular diseases. This study evaluated associations between uric acid (UA), cardiovascular health, and neurocognitive function in adolescent and adult survivors of childhood acute lymphoblastic leukemia treated with chemotherapy only.
   Methods: 126 adolescent [mean (SD) age 14.6 (5.0); 7.8 (1.7) years postdiagnosis] and 226 adult survivors [age 25.4 (4.2) years; 18.1 (4.4) years postdiagnosis] completed comprehensive neurocognitive testing. Concurrent UA measurements were conducted for both groups. For adult survivors, cardiovascular risk factors were assessed, and UA measurements during adolescence [12.3 (4.0) years before neurocognitive testing] were also collected. UA levels were categorized into quartiles for age-and gender-based ranking, and associations with neurocognitive outcomes were examined.
   Results: Survivors demonstrated worse attention, processing speed, and executive functions than population norms (P values < 0.05). Adolescent survivors with elevatedUAhad poorer attention (P = 0.04), visual-processing speed (P = 0.03), and cognitive flexibility (P = 0.02). UA was not associated with neurocognitive outcomes in adult survivors. Adult survivors developed dyslipidemia (46%), hypertension (32%), and abdominal obesity (26%), and high UA during adolescence was associated with these cardiovascular risk factors as adults (all P values < 0.01). Finemotor processing speed was slower in adult survivors with dyslipidemia (P = 0.04) and abdominal obesity (P = 0.04). Poorer attention was marginally associated with hypertension (P = 0.06).
   Conclusions: Elevated UA is associated with neurocognitive performance in adolescent survivors. In adult survivors, relative elevation of UA during adolescence was predictive of cardiovascular health, which was associated with poorer neurocognitive outcomes.
   Impact: Future studies should evaluate the mediating role of chronic cardiovascular health conditions between elevated UA and subsequent neurocognitive impairment in survivors. (C) 2016 AACR.
C1 [Cheung, Yin Ting; Green, Daniel M.; Robison, Leslie L.; Krull, Kevin R.] St Jude Childrens Res Hosp, Dept Epidemiol & Canc Control, 332 N Lauderdale St, Memphis, TN 38105 USA.
   [Edelmann, Michelle N.] Univ Denver, Dept Psychol, Denver, CO 80208 USA.
   [Mulrooney, Daniel A.; Hudson, Melissa M.] St Jude Childrens Res Hosp, Dept Oncol, 332 N Lauderdale St, Memphis, TN 38105 USA.
   [Chemaitilly, Wassim] St Jude Childrens Res Hosp, Dept Endocrinol, 332 N Lauderdale St, Memphis, TN 38105 USA.
   [John, Neena] Univ Alabama Birmingham, Birmingham, AL USA.
   [Krull, Kevin R.] St Jude Childrens Res Hosp, Dept Psychol, 332 N Lauderdale St, Memphis, TN 38105 USA.
C3 St Jude Children's Research Hospital; University of Denver; St Jude
   Children's Research Hospital; St Jude Children's Research Hospital;
   University of Alabama System; University of Alabama Birmingham; St Jude
   Children's Research Hospital
RP Krull, KR (corresponding author), St Jude Childrens Res Hosp, Epidemiol & Canc Control, MS 735, 262 Danny Thomas Pl, Memphis, TN 38105 USA.
EM kevin.krull@stjude.org
RI Chemaitilly, Wassim/AAQ-3397-2021; Cheung, Yin Ting/AAT-4384-2021;
   hayashi, robert/AAH-2077-2019; Hudson, Melissa/N-4441-2018; Robison,
   Leslie/N-8122-2018; Krull, Kevin/N-3882-2018
OI Krull, Kevin/0000-0002-0476-7001; Cheung, Yin Ting/0000-0001-9874-8938
FU National Institute of Mental Health [MH085849]; National Cancer
   Institute [U01CA195547-01]; American Lebanese Syrian Associated
   Charities (ALSAC)
FX This work was supported by the National Institute of Mental Health
   (MH085849; to K.R. Krull), the National Cancer Institute
   (U01CA195547-01; to M.M. Hudson and L.L. Robison), and by the American
   Lebanese Syrian Associated Charities (ALSAC).
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NR 62
TC 12
Z9 14
U1 3
U2 9
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 1055-9965
EI 1538-7755
J9 CANCER EPIDEM BIOMAR
JI Cancer Epidemiol. Biomarkers Prev.
PD AUG
PY 2016
VL 25
IS 8
BP 1259
EP 1267
DI 10.1158/1055-9965.EPI-16-0118
PG 9
WC Oncology; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Public, Environmental & Occupational Health
GA DV6JV
UT WOS:000383042300009
PM 27345588
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Briana, DD
   Baka, S
   Boutsikou, M
   Boutsikou, T
   Xagorari, M
   Gourgiotis, D
   Malamitsi-Puchner, A
AF Briana, Despina D.
   Baka, Stavroula
   Boutsikou, Maria
   Boutsikou, Theodora
   Xagorari, Marieta
   Gourgiotis, Dimitrios
   Malamitsi-Puchner, Ariadne
TI Cord blood copeptin concentrations in fetal macrosomia
SO METABOLISM-CLINICAL AND EXPERIMENTAL
LA English
DT Article
DE Copeptin; AVP; Insulin; Cord blood; Fetal macrosomia
ID METABOLIC SYNDROME; BIRTH-WEIGHT; DIABETES-MELLITUS; PLASMA COPEPTIN;
   INSULIN-RESISTANCE; GESTATIONAL-AGE; VASOPRESSIN RESPONSES; VAGINAL
   DELIVERY; BORN LARGE; OBESITY
AB Background/aim. Excessive fetal growth is associated with increased adiposity and reduced insulin sensitivity at birth. Copeptin, a surrogate marker of arginine vasopressin (AVP) secretion, is upregulated in states of hyperinsulinemia and is considered one of the mediators of insulin resistance. We aimed to investigate cord blood concentrations of copeptin (C-terminal fragment of AVP pro-hormone) in healthy large-for-gestational-age (LGA) infants at term.
   Methods. This prospective study was conducted on 30 LGA (n = 30) and 20 appropriatefor-gestational-age (AGA, n = 20) singleton full-term healthy infants. Cord blood copeptin and insulin concentrations were determined by ELISA and IRMA, respectively. Infants were classified as LGA or AGA, based on customized birth-weight standards adjusted for significant determinants of fetal growth.
   Results. Cord blood copeptin concentrations were similar in LGA cases, compared to AGA controls, after adjusting for delivery mode. However, in the LGA group, cord blood copeptin concentrations positively correlated with birth-weight (r = 0.422, p = 0.020). In the AGA group, cord blood copeptin concentrations were elevated in cases of vaginal delivery vs elective cesarean section (p = 0.003). Cord blood insulin concentrations were higher in LGA cases, compared to AGA controls (p = 0.036). No association was recorded between cord blood copeptin concentrations and maternal age, parity, gestational age or fetal gender in both groups.
   Conclusions. Cord blood copeptin concentrations may not be up-regulated in non-distressed LGA infants. However, the positive correlation between cord blood copeptin concentrations and birth-weight in the LGA group may point to the documented association between AVP release and increased fat deposition. Vaginal delivery vs elective cesarean section is accompanied by a marked stress-related increase of cord blood copeptin concentrations. (C) 2016 Elsevier Inc. All rights reserved.
C1 [Briana, Despina D.; Baka, Stavroula; Boutsikou, Maria; Boutsikou, Theodora; Malamitsi-Puchner, Ariadne] Univ Athens, Sch Med, Dept Neonatol, GR-11527 Athens, Greece.
   [Xagorari, Marieta; Gourgiotis, Dimitrios] Univ Athens, Sch Med, Dept Pediat 2, Lab Clin Biochem Mol Diagnost, GR-11527 Athens, Greece.
C3 National & Kapodistrian University of Athens; Athens Medical School;
   National & Kapodistrian University of Athens; Athens Medical School
RP Malamitsi-Puchner, A (corresponding author), 19 Soultani St, Athens 10682, Greece.
EM amalpu@aretaieio.uoa.gr
RI Boutsikou, Maria/AAX-7289-2020
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NR 51
TC 7
Z9 7
U1 0
U2 0
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0026-0495
EI 1532-8600
J9 METABOLISM
JI Metab.-Clin. Exp.
PD JAN
PY 2016
VL 65
IS 1
BP 89
EP 94
DI 10.1016/j.metabol.2015.09.018
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA CZ2TN
UT WOS:000366957600010
PM 26477270
DA 2025-06-11
ER

PT J
AU Rosenblat, JD
   Brietzke, E
   Mansur, RB
   Maruschak, NA
   Lee, Y
   McIntyre, RS
AF Rosenblat, Joshua D.
   Brietzke, Elisa
   Mansur, Rodrigo B.
   Maruschak, Nadia A.
   Lee, Yena
   McIntyre, Roger S.
TI Inflammation as a neurobiological substrate of cognitive impairment in
   bipolar disorder: Evidence, pathophysiology and treatment implications
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Review
DE Cytokines; Mood disorders; Inflammation; Anti-inflammatory agents;
   TNF-alpha; Infliximab
ID CENTRAL-NERVOUS-SYSTEM; C-REACTIVE PROTEIN; N-ACETYL CYSTEINE;
   DOUBLE-BLIND; METABOLIC SYNDROME; PSYCHIATRIC-DISORDERS; ADJUNCTIVE
   TREATMENT; ALZHEIMERS-DISEASE; ADULT LIFE; HPA AXIS
AB Background: Bipolar disorder (BD) has been associated with cognitive impairment during depressed, manic and euthymic periods. Inflammation has been shown to be involved in the pathophysiology of BD and cognitive impairment.
   Methods: For this systematic review, the MEDLINIE/PubMed, Embase, Google Scholar and ClinicalTrials.gov databases were searched for relevant articles assessing the association between cognitive function and inflammatory markers in BD subjects. A discussion of potential mechanisms and therapeutic implications is also included to provide further context to the subject matter.
   Results: Eight studies, including a total of 555 BD subjects, assessing the association between cognitive Function and inflammatory markers were identified. Cognitive dysfunction was associated with elevated levels of pro-inflammatory markers YKL40, IL-6, sCD40L, IL-1Ra, hsCRP and TNF-alpha. Mechanistically, elevation in inflammatory cytokines alters monoamine levels leading to cognitive and affective dysfunction. Neuro-inflammation, manifesting as microglial activation, leads to increased oxidative stress, pathologic synaptic pruning and impaired neuroplasticity in key brain regions sub-serving mood and cognition. Immune dysfunction also activates the hypothalamic-pituitary-adrenal (I-IPA) axis leading to hypercortisolemia and metabolic dysfunction, further promoting neuronal dysfunction. Anti-inflammatory agents are therefore currently being investigated in the treatment of BD and appear to exert an antidepressant effect; however, cognitive outcomes have yet to be reported.
   Conclusion: Several studies suggest that immune dysfunction is associated with cognitive impairment in BD. Several neurobiological pathways have been identified whereby immune dysfunction may promote cognitive impairment in BD. Future investigations of anti-inflammatory agents targeting cognitive function as a treatment outcome are merited. (c) 2015 Elsevier B.V. All rights reserved.
C1 [Rosenblat, Joshua D.; Mansur, Rodrigo B.; Maruschak, Nadia A.; Lee, Yena; McIntyre, Roger S.] Univ Hlth Network, Mood Disorder Psychopharmacol Unit, Toronto, ON M5T 2S8, Canada.
   [Rosenblat, Joshua D.; McIntyre, Roger S.] Univ Toronto, Dept Psychiat, Toronto, ON M5T 2S8, Canada.
   [Brietzke, Elisa; Mansur, Rodrigo B.] Univ Fed Sao Paulo, Interdisciplinary Lab Clin Neurosci LINC, Sao Paulo, Brazil.
   [Brietzke, Elisa; Mansur, Rodrigo B.] Fed Univ Sao Pauloderal Sao Paulo, Program Recognit & Intervent Individuals AT Risk, Dept Psychiat, Univ FeInterdisciplinary Lab Clin Neurosci LINC, Sao Paulo, Brazil.
C3 University of Toronto; University Health Network Toronto; University of
   Toronto; Universidade Federal de Sao Paulo (UNIFESP)
RP McIntyre, RS (corresponding author), Univ Toronto, Psychiat & Pharmacol, 399 Bathurst St,MP 9-325, Toronto, ON M5T 2S8, Canada.
EM roger.mcintyre@uhn.ca
RI Lee, Yena/L-5505-2019; Brietzke, Elisa/G-9559-2012; Mansur,
   Rodrigo/N-7131-2019; McIntyre, Roger/AAU-1000-2020
OI Lee, Yena/0000-0003-0629-9456; Rosenblat, Joshua/0000-0002-4773-2191
FU CNPq (Brazil); FAPESP (Brazil); CAPES (Brazil); Lundbeck; Astra Zeneca;
   Pfizer; Shire; Otsuka; Bristol Myers Squibb; National Institute of
   Mental Health; Stanley Medical Research Institute; Canadian Institutes
   for Health Research; Brain and Behavior Research Foundation; Elli Lilly;
   Janssen Ortho; Sunovion; Takeda; Forest
FX EB has been supported by CNPq (Brazil), FAPESP (Brazil) and CAPES
   (Brazil). RSM has received research grant support from Lundbeck, Astra
   Zeneca, Pfizer, Shire, Otsuka, Bristol Myers Squibb, National Institute
   of Mental Health, Stanley Medical Research Institute, Canadian
   Institutes for Health Research, and The Brain and Behavior Research
   Foundation. RSM has also received speaker/consultant fees from Lundbeck,
   Pfizer, Astra Zeneca, Elli Lilly, Janssen Ortho, Sunovion, Takeda,
   Forest, Otsuka, Bristol Myers Squibb and Shire.
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NR 155
TC 130
Z9 141
U1 1
U2 41
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD DEC 1
PY 2015
VL 188
BP 149
EP 159
DI 10.1016/j.jad.2015.08.058
PG 11
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA CV3OI
UT WOS:000364168100021
PM 26363613
DA 2025-06-11
ER

PT J
AU Sela, M
   Tirza, G
   Ravid, O
   Volovitz, I
   Solodeev, I
   Friedman, O
   Zipori, D
   Gur, E
   Krelin, Y
   Shani, N
AF Sela, M.
   Tirza, G.
   Ravid, O.
   Volovitz, I.
   Solodeev, I.
   Friedman, O.
   Zipori, D.
   Gur, E.
   Krelin, Y.
   Shani, N.
TI NOX1-induced accumulation of reactive oxygen species in abdominal
   fat-derived mesenchymal stromal cells impinges on long-term
   proliferation
SO CELL DEATH & DISEASE
LA English
DT Article
ID PERIVASCULAR ADIPOSE-TISSUE; STEM-CELLS; OXIDATIVE STRESS; NADPH
   OXIDASES; VISCERAL FAT; GROWTH; DIFFERENTIATION; SENESCENCE; EXPRESSION;
   CULTURE
AB Mesenchymal stromal cells (MSCs) are multipotent and can be derived from different adult tissues including fat. Our repeated attempts to produce long-term proliferative cultures of rat abdominal adipose stem cells (aASCs) under normal oxygen concentration (21%) were unsuccessful. We set to examine the events controlling this cytostasis of aASCs and found that it resulted from overproduction of reactive oxygen species (ROS) that led to apoptosis. ROS overproduction in aASCs was accompanied by increased expression of NOX1 but not of NOX2 or NOX4. NOX family members are an important source of intracellular ROS pointing to NOX1 involvement in ROS accumulation. This was verified when aASCs that were grown under 3% oxygen conditions expanded long term, displaying reduced NOX1 expression and decreased ROS accumulation. NOX1 involvement in aASC cytostasis was reaffirmed when cells that were expanded under normoxic conditions in the presence of a specific NOX1 inhibitor, ML171, demonstrated reduced ROS accumulation, reduced apoptosis and long-term expansion. aASC expansion arrest was accompanied also by a weak fat differentiation and migratory potential, which was enhanced by NOX1 inhibition. This suggests an inhibitory role for NOX1-induced ROS overproduction on aASCs, their fat differentiation and migratory potential. In contrast to aASCs, similar cells produced from subcutaneous fat were easily expanded in normoxic cultures, exhibiting low ROS concentrations, a low number of apoptotic cells and improved fat differentiation and migration. Taken together, our results show, for the first time, that NOX1-induced ROS accumulation halts ASC expansion and reduces their differentiation and migratory potential under normoxic conditions. Importantly, this phenotype comprises a tissue-specific signature as it was evident in aASCs but not in subcutaneous ASCs. NOX-induced ROS accumulation and cytokine production by fat are part of the metabolic syndrome. The similarity of this phenomenon to aASC phenotype may indicate that they arise from similar molecular mechanisms.
C1 [Sela, M.; Tirza, G.; Solodeev, I.; Friedman, O.; Gur, E.; Krelin, Y.; Shani, N.] Tel Aviv Univ, Tel Aviv Sourasky Med Ctr, Dept Plast Surg, IL-6423906 Tel Aviv, Israel.
   [Ravid, O.; Zipori, D.] Weizmann Inst Sci, Dept Mol Cell Biol, IL-76100 Rehovot, Israel.
   [Volovitz, I.] Tel Aviv Univ, Tel Aviv Sourasky Med Ctr, Neurosurg Dept, IL-6423906 Tel Aviv, Israel.
C3 Tel Aviv University; Sackler Faculty of Medicine; Tel Aviv Sourasky
   Medical Center; Weizmann Institute of Science; Tel Aviv University;
   Sackler Faculty of Medicine; Tel Aviv Sourasky Medical Center
RP Krelin, Y (corresponding author), Tel Aviv Univ, Tel Aviv Sourasky Med Ctr, Dept Plast Surg, 6 Weizmann St, IL-6423906 Tel Aviv, Israel.
EM kreliny@gmail.com; nirs@tlvmc.gov.il
RI Friedman, Or/I-1578-2019; Tirza, Gal/ITV-8652-2023
OI Tirza, Gal/0000-0002-3544-1047; Friedman, Or/0000-0002-4362-7909
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NR 48
TC 19
Z9 19
U1 0
U2 2
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 2041-4889
J9 CELL DEATH DIS
JI Cell Death Dis.
PD APR
PY 2015
VL 6
AR e1728
DI 10.1038/cddis.2015.84
PG 11
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA CM2LL
UT WOS:000357511500021
PM 25880095
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Alashry, SE
   Gaballah, MA
   Malek, HA
   Abd Elsalam, AI
AF Alashry, Shereen Ezzelregal
   Gaballah, Mohammad A.
   Malek, Hala Abdel
   Abd Elsalam, Adel I.
TI Effect of Sildenafil on Non-Alcoholic Fatty Liver
SO INTERNATIONAL JOURNAL OF PHARMACOLOGY
LA English
DT Article
DE Sildenafil; non-alcoholic fatty liver disease; erectile dysfunction
ID ERECTILE DYSFUNCTION; METABOLIC SYNDROME; INSULIN-RESISTANCE; OXIDATIVE
   STRESS; STEATOHEPATITIS; DIAGNOSIS; IMPROVES; DISEASE; IMPACT; MEN
AB Non Alcoholic Fatty Liver Disease (NAFLD) is now the commonest liver disease worldwide and can evolve into cirrhosis in a subgroup of patients. Sildenafil citrate is a specific phosphodiesterase-5 (PDE-5) inhibitor, which has been approved for treatment of erectile dysfunction in men. To examine the effect of sildenafil citrate on NAFLD in animal model and male patients with erectile dysfunction. Sixty male mice were divided into 4 groups: The 1-received a standard diet; 2-fed with a High fat Diet (HFD); 3-HFD + sildenafil citrate; 4-standard diet + sildenafil citrate. The experiments were conducted for 16 weeks, after that, the mice in the treatment groups received 1.4 mg kg(-1) sildenafil citrate base dissolved in distilled water daily for 8 weeks, through orogastric feeding tube. A case-control study enrolled 60 males with erectile dysfunction, who were divided into 30 patients with NAFLD and 30 patients without NAFLD (control group). They received sildenafil citrate 50 mg daily for 8 weeks. It was found that sildenafil administration improved liver enzymes, insulin resistance and lipids level compared to control group in animal model. There were insignificant changes as regard lipid profile, fasting serum insulin and liver enzymes (alkaline phosphatase, alanine 2-oxoglutarate aminotransferase) after sildenafil treatment for 8 weeks in NAFLD group in human study. There was significant decrease in aspartate 2-oxoglutarate aminotransferase (AST) level after sildenafil treatment in NAFLD. There were significant negative correlations between International Index of Erectile Function (IIEF) score and Body Mass Index (BMI), cholesterol and triglycerides levels. Sildenafil is well-tolerated and safe in NAFLD patients. However, it is less effective in NAFLD patients than in individuals without comorbidities. Further investigation is needed to test the effect of long-term sildenafil administration on insulin resistance and lipid profile.
C1 [Alashry, Shereen Ezzelregal; Gaballah, Mohammad A.] Mansoura Univ, Fac Med, Dept Dermatol Androl & STDs, Mansoura, Egypt.
   [Malek, Hala Abdel] Mansoura Univ, Fac Med, Dept Clin Pharmacol, Mansoura, Egypt.
   [Abd Elsalam, Adel I.] Mansoura Univ, Fac Med, Dept Internal Med, Mansoura, Egypt.
C3 Egyptian Knowledge Bank (EKB); Mansoura University; Egyptian Knowledge
   Bank (EKB); Mansoura University; Egyptian Knowledge Bank (EKB); Mansoura
   University
RP Gaballah, MA (corresponding author), Mansoura Univ, Fac Med, Dept Dermatol Androl & STDs, Mansoura, Egypt.
RI gaballah, mohammad/AAO-8694-2020; malek, hala/N-5355-2018
OI gaballah, mohammad/0000-0001-6271-2511; Malek, Hala/0000-0002-8590-9461
CR Ahsan T., 2015, PAK J MED RES, V54, P3
   [Anonymous], 2014, SCI WORLD J
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NR 23
TC 4
Z9 4
U1 0
U2 3
PU ASIAN NETWORK SCIENTIFIC INFORMATION-ANSINET
PI FAISALABAD
PA 308-LASANI TOWN, SARGODHA RD, FAISALABAD, 38090, PAKISTAN
SN 1811-7775
EI 1812-5700
J9 INT J PHARMACOL
JI Int. J. Pharmacol.
PY 2015
VL 11
IS 7
BP 814
EP 820
DI 10.3923/ijp.2015.814.820
PG 7
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA DC4TW
UT WOS:000369214200020
OA Bronze
DA 2025-06-11
ER

PT J
AU Macrea, M
   Martin, T
   Jia, ZQ
   Misra, H
AF Macrea, Madalina
   Martin, Thomas
   Jia, Zhenquan
   Misra, Hara
TI Leptin's Activity on the Hydroxyl Radical: A Possible Link to the
   Oxidative Stress-Related Endothelial Vasodilation in Patients with
   Obstructive Sleep Apnea
SO LUNG
LA English
DT Article
DE Leptin; Obstructive sleep apnea; Hydroxyl radical; Vasodilation
ID CARDIOVASCULAR RISK-FACTORS; METABOLIC SYNDROME; DISEASE; ANGIOGENESIS;
   ASSOCIATION; RECEPTOR; PROTEIN
AB Obstructive sleep apnea (OSA) is associated with increased cardiovascular morbidity, whereas the underlying mechanism is still eluding, the thought participants are chronic intermittent hypoxia with consequent increase in the reactive oxygen species, leading to endothelial cell damage and dysfunction in these patients. As the hydroxyl radical (center dot OH) mediates the vascular smooth muscle relaxation, identification of its scavengers might reveal sentinel markers of decreased vascular responsiveness and worse long-term comorbid outcome. We therefore assessed leptin's scavenger effect on (OH)-O-a (TM) using the electronic paramagnetic resonance (EPR) method.
   The (OH)-O-a (TM) was generated by the Fenton reaction in the presence of spin-trap 5-diethoxyphosphoryl-5-methyl-1-pyrroline N-oxide (DMPO) with various concentrations of leptin (0.25, 2.5, and 25 mu g/ml) and without leptin. EPR spectrometer settings were: modulation frequency, 100 kHz; X band microwave frequency, 9.5 GHz; microwave power, 20 mW (milliwatts); modulation amplitude, 1.0 G (gauss); time constant, 160 s; scan time, 200 s; and receiver gain, 1 x l0(5). EPR signal intensity between 3,440 and 3,540 G of measurements taken in at least three separate experiments was reported. Mannitol, a known (OH)-O-a (TM) scavenger, at 100 mM significantly decreased the DMPO-OH adduct formation and was used as the active-control agent.
   Leptin added to aqueous solutions at all concentrations was associated with a statistically significant decrease in EPR signal compared with controls due to its scavenging activity towards the center dot OH.
   Leptin could be further investigated as a sentinel biomarker of decreased vascular responsiveness and future risk of atherosclerotic disease in obese OSA patients.
C1 [Macrea, Madalina; Martin, Thomas] Salem VA Med Ctr, Dept Pulm, Salem, VA 24153 USA.
   [Jia, Zhenquan] Univ N Carolina, Greensboro, NC 27402 USA.
   [Misra, Hara] Virginia Tech Corp Res, Edward Via Virginia Coll Osteopath Med, Blacksburg, VA 24060 USA.
C3 US Department of Veterans Affairs; Veterans Health Administration (VHA);
   Salem Veterans Affairs Medical Center; University of North Carolina;
   University of North Carolina Greensboro; Edward Via College of
   Osteopathic Medicine (VCOM)
RP Macrea, M (corresponding author), Salem VA Med Ctr, Dept Pulm, 1970 Roanoke Blvd, Salem, VA 24153 USA.
EM Madalina.Macrea@va.gov
CR Aoqui C, 2013, EUR J CLIN NUTR, V67, P610, DOI 10.1038/ejcn.2013.66
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NR 32
TC 0
Z9 0
U1 0
U2 12
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0341-2040
EI 1432-1750
J9 LUNG
JI Lung
PD AUG
PY 2013
VL 191
IS 4
BP 391
EP 395
DI 10.1007/s00408-013-9466-4
PG 5
WC Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Respiratory System
GA 184TQ
UT WOS:000321916800011
PM 23689876
DA 2025-06-11
ER

PT J
AU Ping, J
   Lei, YY
   Liu, L
   Wang, TT
   Feng, TH
   Wang, H
AF Ping, Jie
   Lei, You-ying
   Liu, Lian
   Wang, Ting-ting
   Feng, Ting-hong
   Wang, Hui
TI Inheritable stimulatory effects of caffeine on steroidogenic acute
   regulatory protein expression and cortisol production in human
   adrenocortical cells
SO CHEMICO-BIOLOGICAL INTERACTIONS
LA English
DT Article
DE Caffeine; Steroidogenesis; Steroidogenic acute regulatory protein;
   Cortisol; DNA methylation
ID ELEMENT BINDING-PROTEIN; DNA METHYLATION; GENE-EXPRESSION; METABOLIC
   SYNDROME; TRANSCRIPTIONAL ACTIVATION; CONSUMPTION; BIOSYNTHESIS;
   BEHAVIOR; P450C17; COFFEE
AB Caffeine is the most widely consumed psychoactive substance in the world. It can elevate the level of glucocorticoid which is involved in metabolism regulation, stress response, and immune function. However, the specific mechanism has yet to be elucidated. Glucocorticoid is steroid hormone synthesized in adrenal cortex and the key rate-limiting step in its biosynthesis is mediated by steroidogenic acute regulatory protein (StAR). This study was designed to investigate the direct effects and inheritable epigenetic mechanisms of caffeine on cortisol production and StAR expression in human adrenocortical cells. The human adrenocortical cell line NCI-H295A was cultured with 0.4-40 mu M caffeine. There was a significant increase of the cortisol production in cells. In both acutely and chronically caffeine-treated cell groups, mRNA and protein expressions of StAR were stimulated in a dose-dependent manner. DNA methylation detection via bisulfite-sequencing PCR (BSP) uncovered a single site CpG demethylation at nt -682 within the StAR promoter region. Then we investigated how long the increased StAR expression and the single CpG demethylation could last. The caffeine was withdrawn after 48 h of treatment and then the cells were continually subcultured for up to 5 and 10 passages, respectively. The results showed that the StAR expression at post-caffeine passage 10 still increased, as compared with that in the control. The caffeine-induced demethylation at nt -682 in StAR promoter underwent a similar time course as StAR expression does. The present study reveals the direct effect and possible inheritable epigenetic mechanism of caffeine on steroidogenesis in human adrenocortical cells and has implications for our understanding of the consumption of caffeine. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
C1 [Ping, Jie; Lei, You-ying; Liu, Lian; Wang, Ting-ting; Wang, Hui] Wuhan Univ, Basic Med Sch, Dept Pharmacol, Wuhan 430072, Peoples R China.
   [Ping, Jie; Wang, Ting-ting; Feng, Ting-hong] Uniformed Serv Univ Hlth Sci, Dept Pharmacol, Bethesda, MD 20814 USA.
   [Ping, Jie; Wang, Hui] Wuhan Univ, Res Ctr Food & Drug Evaluat, Wuhan 430072, Peoples R China.
C3 Wuhan University; Uniformed Services University of the Health Sciences -
   USA; Wuhan University
RP Ping, J (corresponding author), 185 DongHu Rd, Wuhan 430071, Peoples R China.
EM pingjie1980@163.com; wanghui19@whu.edu.cn
RI wang, tingting/AAK-2640-2020
FU National Natural Science Foundation of China [30800931, 30830112,
   81173138, 30672566]; Wuhan University [4101028]
FX This work is supported by the National Natural Science Foundation of
   China (No. 30800931, 30830112, 81173138, 30672566) and The Independent
   Innovation Projects of Wuhan University (No. 4101028).
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NR 56
TC 21
Z9 23
U1 0
U2 30
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0009-2797
EI 1872-7786
J9 CHEM-BIOL INTERACT
JI Chem.-Biol. Interact.
PD JAN 5
PY 2012
VL 195
IS 1
BP 68
EP 75
DI 10.1016/j.cbi.2011.11.001
PG 8
WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology
GA 887HO
UT WOS:000299917700009
PM 22100783
DA 2025-06-11
ER

PT J
AU Zhu, CS
   Xiong, ZJ
   Zheng, ZD
   Chen, YM
   Chen, XH
   Qian, XX
AF Zhu, Cansheng
   Xiong, Zhaojun
   Zheng, Zhenda
   Chen, Yanming
   Chen, Xiaohong
   Qian, Xiaoxian
TI Association of Arterial Stiffness with Serum Bilirubin Levels in
   Established Coronary Artery Disease
SO INTERNAL MEDICINE
LA English
DT Article
DE brachial-ankle pulse wave velocity; arterial stiffness; coronary artery
   disease; total bilirubin; antioxidant
ID PULSE-WAVE VELOCITY; LOW-DENSITY-LIPOPROTEIN; INTIMA-MEDIA THICKNESS;
   SYSTEMIC INFLAMMATION; OXIDATIVE STRESS; METABOLIC SYNDROME; HEME
   OXYGENASE; HEART-FAILURE; MUSCLE-CELLS; RISK-FACTORS
AB Objective Elevated serum bilirubin concentrations protect from atherosclerotic diseases, however it is not clear whether or not higher serum bilirubin concentrations have the same effect in coronary artery disease (CAD). The brachial-ankle pulse wave velocity (baPWV) is a reproducible method to assess arterial stiffness. This study was aimed to investigate the relationship between serum total bilirubin (TB) and baPWV in patients with established CAD.
   Methods We enrolled 638 patients (390 men, 248 women) with established CAD. TB was divided into tertiles. Simple and multiple linear regression analyses were used to assess the correlation between baPWV and TB.
   Results The mean baPWV tended to decrease in men according to TB tertiles: Tertile 1=2,126.0, Tertile 2=1,832.5, and Tertile 3=1,692.5 cm/s. Likewise, the mean baPWV tended to decrease in women according to TB tertiles: Tertile 1=1,920.8, Tertile 2=1,829.0, and Tertile 3=1,701.3 cm/s. Univariate analysis showed that age, BMI, TB, ALT, GGT, Cho, SBP, DBP, UA, and TC were significantly associated with baPWV in men. In women, age, BMI, current smoker, Cho, SBP, DBP, UA, TC, TG, HDL-C, and LDL-C were significantly associated with baPWV. BMI, LnSBP, UA, TB, LnCho, and LnTC were correlated with baPWV in men in the multivariate model. However, only LnSBP, UA, and LnHDL-C were correlated with baPWV in women. TB was found to be a significant determinant for decreased baPWV only in men (beta=-0.136; p<0.001).
   Conclusion Our findings show that the level of total serum bilirubin is negatively correlated with arterial stiffness in men with established CAD.
C1 [Xiong, Zhaojun; Zheng, Zhenda; Qian, Xiaoxian] Sun Yat Sen Univ, Affiliated Hosp 3, Dept Cardiovasc Dis, Guangzhou, Peoples R China.
   [Zhu, Cansheng; Chen, Xiaohong] Sun Yat Sen Univ, Affiliated Hosp 3, Dept Neurol, Guangzhou, Peoples R China.
   [Chen, Yanming] Sun Yat Sen Univ, Affiliated Hosp 3, Dept Endocrinol & Metab, Guangzhou, Peoples R China.
C3 Sun Yat Sen University; Sun Yat Sen University; Sun Yat Sen University
RP Qian, XX (corresponding author), Sun Yat Sen Univ, Affiliated Hosp 3, Dept Cardiovasc Dis, Guangzhou, Peoples R China.
EM xiaoxianqianzssy@yahoo.com.cn
RI Wu, Zhenhua/M-9894-2017; zheng, ziwen/LFR-7449-2024
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NR 45
TC 8
Z9 10
U1 0
U2 8
PU JAPAN SOC INTERNAL MEDICINE
PI TOKYO
PA 34-3 3-CHOME HONGO BUNKYO-KU, TOKYO, 113, JAPAN
SN 0918-2918
J9 INTERNAL MED
JI Intern. Med.
PY 2012
VL 51
IS 16
BP 2083
EP 2089
DI 10.2169/internalmedicine.51.7701
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 999NK
UT WOS:000308320300003
PM 22892483
OA hybrid
DA 2025-06-11
ER

PT J
AU Gunji, T
   Matsuhashi, N
   Sato, H
   Fujibayashi, K
   Okumura, M
   Sasabe, N
   Urabe, A
AF Gunji, Toshiaki
   Matsuhashi, Nobuyuki
   Sato, Hajime
   Fujibayashi, Kazutoshi
   Okumura, Mitsue
   Sasabe, Noriko
   Urabe, Akio
TI Light and Moderate Alcohol Consumption Significantly Reduces the
   Prevalence of Fatty Liver in the Japanese Male Population
SO AMERICAN JOURNAL OF GASTROENTEROLOGY
LA English
DT Article
ID ELEVATED ALANINE AMINOTRANSFERASE; UNITED-STATES; BLOOD-DONORS;
   RISK-FACTORS; CLINICAL-SIGNIFICANCE; INSULIN SENSITIVITY; METABOLIC
   SYNDROME; HEPATIC STEATOSIS; OXIDATIVE STRESS; DISEASE
AB OBJECTIVES: The effect of alcohol consumption on the liver is controversial. Recent reports have suggested that moderate alcohol consumption decreases the prevalence of elevated alanine aminotransferase levels. The role of alcohol consumption in the development of fatty liver (FL), however, has not been studied definitively. The aim of this study was to examine the association between alcohol consumption and FL in a large Japanese population.
   METHODS: A total of 7,431 asymptomatic male subjects who underwent a complete medical survey in our institute between May 2007 and July 2008 were recruited. Cases positive for hepatitis B or C viruses, potential hepatotoxic drug intake, or under treatment for metabolic disorders were excluded. FL was defined by ultrasonography. Visceral and subcutaneous adipose tissues (VAT and SAT) were measured by computed tomography. Independent and significant predictors associated with FL were determined by multiple logistic regression analysis.
   RESULTS: Of the initial study candidates, 130 (1.7%) were positive for hepatitis B and 66 (0.8%) were positive for hepatitis C. On the basis of the inclusion and exclusion criteria, 5,599 men (50.9 +/- 8.1 years) were studied cross-sectionally. Light (40-140 g/week) and moderate (140-280 g/week) alcohol consumption significantly and independently reduced the likelihood of FL (odds ratio = 0.824 and 0.754, 95% confidence interval = 0.683-0.994 and 0.612-0.928, P = 0.044 and 0.008, respectively) by multivariate analysis after adjusting for potential confounding variables. VAT, SAT, low-density lipoprotein, triglycerides, and fasting blood glucose were significant predictors of the increased prevalence of FL, whereas age was a predictor of the decreased prevalence of FL.
   CONCLUSIONS: The prevalence of FL was significantly and independently decreased by light and moderate alcohol consumption in men of an asymptomatic Japanese population.
C1 [Matsuhashi, Nobuyuki] NTT E, Kanto Med Ctr, Dept Gastroenterol, Tokyo 1418625, Japan.
   [Gunji, Toshiaki; Fujibayashi, Kazutoshi; Okumura, Mitsue; Sasabe, Noriko; Urabe, Akio] NTT E, Kanto Med Ctr, Ctr Prevent Med, Tokyo 1418625, Japan.
   [Sato, Hajime] Univ Tokyo, Dept Publ Hlth, Grad Sch Med, Tokyo, Japan.
C3 Kanto Medical Center NTT EC; Kanto Medical Center NTT EC; University of
   Tokyo
RP Matsuhashi, N (corresponding author), NTT E, Kanto Med Ctr, Dept Gastroenterol, 5-9-22 Higashi Gotanda, Tokyo 1418625, Japan.
EM nmatuha-tky@umin.ac.jp
OI Matsuhashi, Nobuyuki/0000-0002-0139-430X; Sato,
   Hajime/0000-0003-0796-0189
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NR 48
TC 96
Z9 97
U1 0
U2 7
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 0002-9270
EI 1572-0241
J9 AM J GASTROENTEROL
JI Am. J. Gastroenterol.
PD SEP
PY 2009
VL 104
IS 9
BP 2189
EP 2195
DI 10.1038/ajg.2009.361
PG 7
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 497AP
UT WOS:000270024800012
PM 19550408
DA 2025-06-11
ER

PT J
AU Tsukuda, K
   Mogi, M
   Li, JM
   Iwanami, J
   Min, LJ
   Sakata, A
   Fujita, T
   Iwai, M
   Horiuchi, M
AF Tsukuda, Kana
   Mogi, Masaki
   Li, Jian-Mei
   Iwanami, Jun
   Min, Li-Juan
   Sakata, Akiko
   Fujita, Teppei
   Iwai, Masaru
   Horiuchi, Masatsugu
TI Amelioration of cognitive impairment in the type-2 diabetic mouse by the
   angiotensin II type-1 receptor blocker candesartan
SO HYPERTENSION
LA English
DT Article
DE angiotensin II receptors; type-2 diabetes mellitus; cognitive impairment
ID OXIDATIVE STRESS; OLDER WOMEN; HYPERTENSIVE PATIENTS;
   ALZHEIMERS-DISEASE; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   RANDOMIZED-TRIAL; PPAR-GAMMA; RISK; MORBIDITY
AB Angiotensin II type-1 receptor blockers are widely used with the expectation of prevention of stroke, potential effects to ameliorate of type-2 diabetes, which seems to be closely associated with the impairment of cognitive function in humans. Recently, we have reported that an angiotensin II type-1 receptor blocker prevented cognitive impairment in mice after focal cerebral ischemia, at least partly through an angiotensin II type-2 receptor-mediated increase in a neuroprotective factor, methyl methanesulfonate sensitive- 2. Here, we examined the possibility that an angiotensin II type-1 receptor blocker could improve cognitive function in a type- 2 diabetic mouse model, KK-A(y). KK-A(y) mice subjected to 20 trials of a passive avoidance task every week from 8 weeks exhibited a significantly impaired avoidance rate, and moreover, its age- dependent decline, especially after 14 weeks of age, compared with age-matched C57BL6 mice. Oral administration of candesartan at a nonhypotensive dose (0.005% in laboratory chow) in KK-A(y) mice improved cognitive function and inhibited the impairment of cognitive decline. Methyl methanesulfonate sensitive-2 expression in the brain was lower in KK-A(y) mice than in C57BL6 mice. Treatment with candesartan markedly increased mRNA expression of angiotensin II type-2 receptor and methyl methanesulfonate sensitive-2 in the brain in KK-A(y) mice, determined by quantitative RT-PCR. In KK-A(y) mice treated with candesartan, age-dependent increases in blood glucose and insulin were significantly suppressed. Our results suggest that candesartan ameliorates the impaired cognitive function in type-2 diabetes mice, at least because of an increased expression of methyl methanesulfonate sensitive-2, a neuroprotective factor, in addition to improvement of glucose intolerance. (Hypertension. 2007; 50: 1099- 1105.).
C1 Ehime Univ, Grad Sch Med, Dept Mol Cardiovasc Biol & Pharmacol, Tohon, Ehime 790, Japan.
C3 Ehime University
RP Horiuchi, M (corresponding author), Ehime Univ, Grad Sch Med, Dept Mol Cardiovasc Biol & Pharmacol, Tohon, Ehime 790, Japan.
EM horiuchi@m.ehime-u.ac.jp
RI Mogi, Masaki/ABH-2011-2020
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NR 37
TC 36
Z9 41
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0194-911X
EI 1524-4563
J9 HYPERTENSION
JI Hypertension
PD DEC
PY 2007
VL 50
IS 6
BP 1099
EP 1105
DI 10.1161/HYPERTENSIONAHA.107.099374
PG 7
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 234EO
UT WOS:000251143700020
PM 17968000
OA Bronze
DA 2025-06-11
ER

PT J
AU Verhulst, SL
   Van Hoeck, K
   Schrauwen, N
   Haentjens, D
   Rooman, R
   Van Gaal, L
   De Backer, WA
   Desager, KN
AF Verhulst, Stijn L.
   Van Hoeck, Koen
   Schrauwen, Nancy
   Haentjens, Dominique
   Rooman, Raoul
   Van Gaal, Luc
   De Backer, Wilfried A.
   Desager, Kristine N.
TI Sleep-disordered breathing and uric acid in overweight and obese
   children and adolescents
SO CHEST
LA English
DT Article
DE adolescence; childhood; obesity; sleep-disordered breathing; uric acid
ID CARDIOVASCULAR RISK-FACTORS; POSITIVE AIRWAY PRESSURE; METABOLIC
   SYNDROME; OXIDATIVE STRESS; APNEA SYNDROME; CREATININE RATIO; HYPOXEMIA;
   ADENOSINE; DISEASE; VALUES
AB Objective: The aim of this study was to determine whether the severity of sleep-disordered breathing (SDB) was associated with increased levels of uric acid (UA), both in serum and in urine, as a marker of tissue hypoxia, in a sample of overweight and obese subjects, irrespective of indexes of adiposity.
   Methods: Consecutive subjects underwent polysomnography, fasting blood sampling, and 24-h urine collection. Outcome parameters were serum UA, UA excretion ([24-h urinary UA X serum creatinine]/utine creatinine) and urinary UA/creatinine ratio.
   Results: A total of 93 subjects were included (44% boys; mean [+/- SD] age = 11.1 +/- 2.5; 73% obese). A fasting measurement of serum UA levels was available for 62 patients. The respiratory disturbance index was a significant covariate (beta = 0.09 +/- 0.03; p = 0.01) in the regression model for serum UA, controlling for sex (beta = 0.32 +/- 0.29; p = 0.3), puberty (beta = 0.87 +/- 0.34; p = 0.01), and waist circumference (beta = 0.04 +/- 0.01; p = 0.005). The percentage of total sleep time with arterial oxygen saturation <= 89% = (beta = 0.94 +/- 0.45; p = 0.04) was also significantly associated with serum UA level, controlling for sex (beta = 0.22 +/- 0.30; p = 0.5), puberty (beta = 0.83 +/- 0.35; p = 0.02), and waist circumference (beta = 0.04 +/- 0.02; p = 0.02). None of the SDB variables correlated with UA excretion or with urinary UA/creatinine ratio.
   Conclusion: This study in overweight children and adolescents demonstrated a relationship between the severity of sleep apnea and increased levels of serum UA, independent of abdominal adiposity. In view of the known associations between UA and cardiovascular risk, this finding may contribute to the mechanisms linking SDB with cardiovascular morbidity.
C1 Univ Antwerp Hosp, Dept Pediat, B-2610 Antwerp, Belgium.
   Univ Antwerp Hosp, Dept Diabetol Metab & Clin Nutr, B-2610 Antwerp, Belgium.
   Univ Antwerp Hosp, Dept Resp Med, B-2610 Antwerp, Belgium.
C3 University of Antwerp; University of Antwerp; University of Antwerp
RP Verhulst, SL (corresponding author), Univ Antwerp, Dept Pediat, Universiteitsplein 1, B-2610 Antwerp, Belgium.
EM stijn.verhulst@ua.ac.be
RI Verhulst, Stijn/B-1702-2008
OI Verhulst, Stijn/0000-0002-1922-9716
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NR 27
TC 54
Z9 58
U1 0
U2 6
PU AMER COLL CHEST PHYSICIANS
PI NORTHBROOK
PA 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 USA
SN 0012-3692
J9 CHEST
JI Chest
PD JUL
PY 2007
VL 132
IS 1
BP 76
EP 80
DI 10.1378/chest.06-2930
PG 5
WC Critical Care Medicine; Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Respiratory System
GA 191OL
UT WOS:000248140600016
PM 17505038
DA 2025-06-11
ER

PT J
AU Araki, S
   Dobashi, K
   Kubo, K
   Yamamoto, Y
   Asayama, K
   Shirahata, A
AF Araki, Shunsuke
   Dobashi, Kazushige
   Kubo, Kazuyasu
   Yamamoto, Yukiyo
   Asayama, Kohtaro
   Shirahata, Akira
TI N-acetylcysteine attenuates TNF-α induced changes in secretion of
   interleukin-6, plasminogen activator inhibitor-1 and adiponectin from
   3T3-L1 adipocytes
SO LIFE SCIENCES
LA English
DT Article
DE obesity; adipocytokines; adipokines; nuclear factor-kappa B; antioxidant
   enzyme
ID NECROSIS-FACTOR-ALPHA; FACTOR-KAPPA-B; NITRIC-OXIDE SYNTHASE;
   SUBCUTANEOUS ADIPOSE-TISSUE; LINKED INSULIN-RESISTANCE; C-6 GLIAL-CELLS;
   OXIDATIVE STRESS; TRANSCRIPTION FACTOR; METABOLIC SYNDROME;
   GENE-EXPRESSION
AB TNF-alpha is a key molecule in obesity-related metabolic disturbances. This study was designed to determine whether N-acetylcysteine (NAC), an antioxidant, prevents the activation of nuclear factor-kappa B (NF-kappa B) by exogenously administered TNF-alpha in adipocytes, and whether such change affects the production of adipocytokines. The treatment of well-differentiated 3T3-L1 cells with 20 mM of NAC significantly increased the reduced glutathione concentration up to 150% of control. The treatment with 10 ng/ml of TNF-alpha decreased antioxidant enzyme levels such as CuZn-superoxide dismutase (SOD), MnSOD and catalase, and activated NF-kappa B in 3T3-L1 adipocytes. The activation of NF-kappa B was significantly prevented by the pretreatment with 20 mM of NAC. TNF-alpha (1-10 ng/ml) dose-dependently increased interleukin (IL)-6 and plasminogen activator inhibitor-1 (PAI-1) secretion from 3T3-L1 adipocytes, while decreased adiponectin secretion. NAC (5-20 mM) attenuated the TNF-alpha-induced changes in these adipocytokine secretions in a dose-dependent manner. The effect of TNF-alpha and NAC on the adipocytokine productions was exerted at the m-RNA level, judging from results of the real time RT-PCR analysis. The present study revealed that NAC inhibited the TNF-alpha-mediated activation of NF-kappa B and improved the adverse changes in the levels of IL-6, PAI-1 and adiponectin in 3T3-L1 adipocytes. NAC may have the potential to improve the obesity-related abnormal adipocytokine metabolism by attenuating the TNF-alpha-induced oxidant-antioxidant imbalance in adipocytes. (c) 2006 Elsevier Inc. All rights reserved.
C1 Univ Occupat & Environm Hlth, Sch Med, Dept Pediat, Yahatanishi Ku, Kitakyushu, Fukuoka 8078555, Japan.
C3 University of Occupational & Environmental Health - Japan
RP Dobashi, K (corresponding author), Univ Occupat & Environm Hlth, Sch Med, Dept Pediat, Yahatanishi Ku, 1-1 Iseigaoka, Kitakyushu, Fukuoka 8078555, Japan.
EM kdobashi@med.uoeh-u.ac.jp
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NR 48
TC 46
Z9 51
U1 0
U2 7
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0024-3205
J9 LIFE SCI
JI Life Sci.
PD NOV 17
PY 2006
VL 79
IS 25
BP 2405
EP 2412
DI 10.1016/j.lfs.2006.08.004
PG 8
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA 111RV
UT WOS:000242472900011
PM 16952378
DA 2025-06-11
ER

PT J
AU Schaan, BD
   Portal, VL
   de Ugarte, MTO
   Dias, AA
   Hatem, DM
AF Schaan, BD
   Portal, VL
   de Ugarte, MTO
   Dias, AA
   Hatem, DM
TI Emerging risk factors and early atherosclerosis indices in subjects with
   impaired glucose tolerance
SO DIABETES & METABOLISM
LA English
DT Article
DE impaired glucose tolerance; postprandial lipaemia; C-reactive protein;
   glucose; triglycerides; fibrinogen; HOMA-IR
ID C-REACTIVE PROTEIN; INTIMA-MEDIA THICKNESS; INSULIN-RESISTANCE;
   POSTPRANDIAL HYPERTRIGLYCERIDEMIA; DIABETES-MELLITUS; OXIDATIVE STRESS;
   PLASMA-GLUCOSE; HEART-DISEASE; LIFE-STYLE; ASSOCIATION
AB Aim: To evaluate the response to an oral lipid overload, inflammatory markers and carotid intima-media thickness in subjects with impaired glucose tolerance.
   Methods: 54 subjects, both sexes, 58 y-old average were submitted to 1) Clinical evaluation 2) Glucose tolerance test with 75 g glucose; classified as normal (2 h plasma glucose < 140 mg/dl, n = 37) or IGT (2 h G 140-200 mg/dl, n = 17), 3) 12 h fasting sample (plasma glucose, lipids, C-reactive protein, fibrinogen and HOMA-IR calculation); 4 and 6 h after the oral lipid overload (1000 kcal, lipids 65 g) glycemia, fibrinogen and triglycerides were reevaluated. Intima-media thickness was calculated by the average of 6 measurements (3 highest of each carotid) evaluated by ultrasonography (7 MHZ transducer).
   Results: The IGT group had higher (P < 0.001) fasting plasma glucose (89.4 +/- 13 vs 104.4 +/- 8 mg/dl), HOMA-IR (1.69 +/- 1.2 vs 2.93 +/- 2.2) and waist (91 +/- 14 vs 101 +/- 9 cm), similar fasting lipids, intima-media thickness (P = 0.58) and post-oral lipid overload triglycerides (P = 0.74), but higher fibrinogen (284.3 +/- 6 and 305 +/- 10 mg/dl, P = 0.05) and C-reactive protein (2.11 +/- 0.33 and 4.19 +/- 0.65 mg/l, P = 0.003). C-reactive protein was positively correlated with HOMA-IR (r = 0.45, P = 0.001), fasting plasma glucose (r = 0.43, P = 0.002) and waist (r = 0.45, P = 0.0006), but not with postprandial lipids.
   Conclusion: A higher C-reactive protein in IGT, and its positive correlation with insulin resistance indices, but not with postprandial lipaemia, suggests that the clustering of these factors, characteristic of the metabolic syndrome, occurs earlier than postprandial lipid abnormalities.
C1 Univ Caixas do Sul, Caixas Do Sul, RS, Brazil.
RP Inst Cardiol Rio Grande Do Sul, Unidade Pesquisa, Dra Av Princesa Isabel 370, BR-90620001 Porto Alegre, RS, Brazil.
EM editoracao-pc@cardiologia.org.br
RI Schaan, Beatriz/I-7518-2017
OI Schaan, Beatriz/0000-0002-2128-8387
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NR 48
TC 6
Z9 8
U1 0
U2 0
PU MASSON EDITEUR
PI MOULINEAUX CEDEX 9
PA 21 STREET CAMILLE DESMOULINS, ISSY, 92789 MOULINEAUX CEDEX 9, FRANCE
SN 1262-3636
EI 1878-1780
J9 DIABETES METAB
JI Diabetes Metab.
PD DEC
PY 2005
VL 31
IS 6
BP 581
EP 587
DI 10.1016/S1262-3636(07)70234-3
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 996ZT
UT WOS:000234215500010
PM 16357807
DA 2025-06-11
ER

PT J
AU Mandal, B
   Das, R
   Mondal, S
AF Mandal, Bitasta
   Das, Rakesh
   Mondal, Sandip
TI Anthocyanins: Potential phytochemical candidates for the amelioration of
   non-alcoholic fatty liver disease
SO ANNALES PHARMACEUTIQUES FRANCAISES
LA English
DT Article
DE Nonalcoholic fatty liver disease; Steatohepatitis; Pathogenesis;
   Anthocyanins; Antioxidant
ID RANDOMIZED CONTROLLED-TRIAL; IN-VIVO; INSULIN-RESISTANCE; HEPATIC
   STEATOSIS; OXIDATIVE STRESS; BLACK-CURRANT; HEALTH-BENEFITS; RECENT
   INSIGHTS; ANTIOXIDANT; STEATOHEPATITIS
AB Nonalcoholic fatty liver disease (NAFLD) is described by too much hepatic fat deposition causing steatosis, which further develops into nonalcoholic steatohepatitis (NASH), defined by necroinflammation and fibrosis, progressing further to hepatic cirrhosis, hepatocellular carcinoma, and liver failure. NAFLD is linked to different aspects of the metabolic syndrome like obesity, insulin resistance, hypertension, and dyslipidemia, and its pathogenesis involves several elements including diet, obesity, disruption of lipid homeostasis, and a high buildup of triglycerides and other lipids in liver cells. It is therefore linked to an increase in the susceptibility to developing diabetes mellitus and cardiovascular diseases. Several interventions exist regarding its management, but the availability of natural sources through diet will be a benefit in dealing with the disorder due to the immensely growing dependence of the popula- tion worldwide on natural sources owing to their ability to treat the root cause of the disease. Anthocyanins (ACNs) are naturally occurring polyphenolic pigments that exist in the form of glycosides, which are the glucosides of anthocyanidins and are produced from flavonoids via the phenyl propanoid pathway. To understand their mode of action in NAFLD and their ther- apeutic potential, the literature on in vitro, in vivo, and clinical trials on naturally occurring ACN-rich sources was exhaustively reviewed. It was concluded that ACNs show their potential in the treatment of NAFLD through their antioxidant properties and their efficacy to control lipid metabolism, glucose homeostasis, transcription factors, and inflammation. This led to the conclusion that ACNs possess efficacy in the amelioration of NAFLD and the various features associated with it. However, additional clinical trials are required to justify the potential of ACNs in NAFLD. (c) 2024 Acade<acute accent>mie Nationale de Pharmacie. Published by Elsevier Masson SAS. All rights reserved.
C1 [Mandal, Bitasta; Das, Rakesh; Mondal, Sandip] Adamas Univ, Sch Hlth & Med Sci, Dept Pharmaceut Technol, Kolkata 700126, India.
RP Mondal, S (corresponding author), Adamas Univ, Sch Hlth & Med Sci, Dept Pharmaceut Technol, Kolkata 700126, India.
EM bitscool27@gmail.com; rdas.jupharmtech@gmail.com; sandip1706@yahoo.com
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NR 159
TC 2
Z9 2
U1 1
U2 6
PU MASSON EDITEUR
PI MOULINEAUX CEDEX 9
PA 21 STREET CAMILLE DESMOULINS, ISSY, 92789 MOULINEAUX CEDEX 9, FRANCE
SN 0003-4509
J9 ANN PHARM FR
JI Ann. Pharm. Fr.
PD MAY
PY 2024
VL 82
IS 3
BP 373
EP 391
DI 10.1016/j.pharma.2024.02.005
EA APR 2024
PG 19
WC Pharmacology & Pharmacy
WE Emerging Sources Citation Index (ESCI)
SC Pharmacology & Pharmacy
GA C3E7H
UT WOS:001288222600001
PM 38354975
DA 2025-06-11
ER

PT J
AU Verma, J
   Rai, AK
   Satija, NK
AF Verma, Julee
   Rai, Ajit Kumar
   Satija, Neeraj Kumar
TI Autophagy perturbation upon acute pyrethroid treatment impacts
   adipogenic commitment of mesenchymal stem cells
SO PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
LA English
DT Article
DE Mesenchymal stem cells; Adipogenesis; Cypermethrin; Permethrin;
   Autophagy
ID OXIDATIVE STRESS; ADIPOSE-TISSUE; INSULIN-RESISTANCE; 3T3-L1 ADIPOCYTES;
   PPAR-GAMMA; DIFFERENTIATION; CYPERMETHRIN; ACTIVATION; PROMOTES;
   TOXICITY
AB Environmental chemical exposure can cause dysregulation in adipogenesis that can result in metabolic syndrome, which includes insulin resistance, type 2 diabetes, cardiovascular disease, as well as excessive body weight. The role of autophagy in adipocyte differentiation is debatable since both positive and negative effects have been reported. Type-I and type-II synthetic pyrethroids & alpha;-cypermethrin (CPM) and permethrin (PER), respectively, are reported to increase adipogenesis in vitro and in vivo. However, it is not known how these pyrethroids affect mesenchymal stem cells (MSCs). Thus, this study focused on evaluating the effect of pyrethroids (CPM and PER) pre-treatment (24 h) on MSC commitment and the regulatory role of autophagy in adipogenic lineage commitment. The formation of adipocytes was observed through nile red staining, perilipin expression by immunoflourescence, and adipogenic markers PPAR & gamma;, C/EBP & alpha;, and FABP4 by western blotting. It was found that the adipogenic differentiation ability of MSCs was significantly increased upon CPM or PER pre-treatment at 100 & mu;M concentration as evident by lipid accumulation and enhanced expression of adipogenic markers. To assess the involvement of autophagy, the expression of p62 and LC3II were evaluated following pre-treatment. Immunoblotting results revealed an increased expression of p62 and LC3II in CPM or PER pretreated MSCs suggesting CPM and PER mediated inhibition of autophagy at 24 h. Further, an increase was observed in adipogenesis upon CPM or PER pre-treatment in combination with chloroquine, while use of rapamycin during pre-treatment abrogated the effect of CPM and PER. Thus, this study concludes that CPM or PER pre-treatment increases the adipogenic differentiation of MSCs. Since chloroquine also demonstrated similar adipogenic response, it further highlights that 24 h pre-treatment with autophagy modulators to inhibit basal autophagy primes MSCs towards adipogenic lineage.
C1 [Verma, Julee; Rai, Ajit Kumar; Satija, Neeraj Kumar] CSIR Indian Inst Toxicol Res, Syst Toxicol Grp Food Drug & Chem Environm & Syst, 31 Mahatma Gandhi Marg, Lucknow 226001, India.
   [Verma, Julee; Rai, Ajit Kumar; Satija, Neeraj Kumar] Acad Sci & Innovat Res AcSIR, Ghaziabad 201002, India.
   [Satija, Neeraj Kumar] CSIR Indian Inst Toxicol Res CSIR IITR, Syst Toxicol Grp Food Drug & Chem Environm & Syst, 31 Mahatma Gandhi Marg, Lucknow 226001, India.
C3 Council of Scientific & Industrial Research (CSIR) - India; CSIR -
   Indian Institute of Toxicology Research (IITR); Academy of Scientific &
   Innovative Research (AcSIR); Council of Scientific & Industrial Research
   (CSIR) - India; CSIR - Indian Institute of Toxicology Research (IITR)
RP Satija, NK (corresponding author), CSIR Indian Inst Toxicol Res CSIR IITR, Syst Toxicol Grp Food Drug & Chem Environm & Syst, 31 Mahatma Gandhi Marg, Lucknow 226001, India.
EM neerajsatija@iitr.res.in
OI Satija, Neeraj/0000-0002-4571-327X
FU CSIR-IITR
FX This study was supported by CSIR-IITR institutional funding.
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NR 47
TC 2
Z9 2
U1 1
U2 4
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0048-3575
EI 1095-9939
J9 PESTIC BIOCHEM PHYS
JI Pest. Biochem. Physiol.
PD SEP
PY 2023
VL 195
AR 105566
DI 10.1016/j.pestbp.2023.105566
EA AUG 2023
PG 9
WC Biochemistry & Molecular Biology; Entomology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Entomology; Physiology
GA R7AG4
UT WOS:001065837500001
PM 37666621
DA 2025-06-11
ER

PT J
AU Liusnea, CS
AF Liusnea, Cristian Stefan
TI Considerations regarding the relationship between Fitness, Wellness and
   Healthy Lifestyle
SO BALNEO AND PRM RESEARCH JOURNAL
LA English
DT Article
DE Fitness; Wellness; Health; Physical education; cultural perspectives
ID SPIRITUALITY; PREVENTION; EXERCISE; MODEL
AB Introduction. Currently, the crises triggered by the pandemic, in the fields of health, freedom of movement, economic, with impact in the social and cultural spheres, bring back today the practical applicability of the concepts of fitness and wellness.
   Material and method. In our study we will refer to the effects of the pandemic on health (everyone's well-being), to see how they accentuated the negative effects of the risks that specialists linked to sedentary lifestyle; increased stress; static antiphysiological positions for prolonged periods of time, which result in cardiovascular disease, metabolic syndrome and even cancer, to which is added an irrational diet. We will also refer to the relationship between the quality of life of people and the need to find the most effective ways to combat the negative effects of risk factors, by overcoming the obstacles posed by the financial situation and cultural patterns both in terms of lifestyle, as well as the eating behavior of people from different backgrounds.
   Results and discussions. We are of the opinion that specialists must go in their approaches, from the cultural understanding of man, to find ways to individualize the means of intervention so as to achieve the proposed objectives. The framework could be, for children and adolescents - the reorganization of school physical education, and for young people and adults - leisure activities, in which the emphasis could be falls on the concepts of Fitness and Wellness, with a beneficial effect on quality of life and personal satisfaction.
   Conclusion In this context, we believe that it is necessary to reconsider the need to make the population aware of the formation of a healthy lifestyle. The means could be physical fitness, wellness, rational nutrition and recovery according to the effort made, their benefits can have a major impact on health and prolong life expectancy.
C1 [Liusnea, Cristian Stefan] Dunarea de Jos Univ Galati, Galati, Romania.
C3 Dunarea De Jos University Galati
RP Liusnea, CS (corresponding author), Dunarea de Jos Univ Galati, Galati, Romania.
RI LIUȘNEA, CRISTIAN/AAP-9283-2021; Liusnea, Cristian Stefan/T-6527-2017
OI Liusnea, Cristian Stefan/0000-0002-3310-6368
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NR 57
TC 0
Z9 0
U1 2
U2 14
PU ROMANIAN ASSOC BALNEOLOGY
PI BUCHAREST
PA BUCHAREST, SECTOR 2, ALEEA DOBRINA NO 7, BL D10, SC A, AP 4, BUCHAREST,
   00000, ROMANIA
SN 2734-844X
EI 2734-8458
J9 BALNEO PRM RES J
JI Balneo PRM Res. J.
PD DEC
PY 2021
VL 12
IS 4
BP 412
EP 417
DI 10.12680/balneo.2021.472
PG 6
WC Rehabilitation
WE Emerging Sources Citation Index (ESCI)
SC Rehabilitation
GA YV0SL
UT WOS:000752443600019
OA gold
DA 2025-06-11
ER

PT J
AU Xu, LS
   Hu, GZ
   Qiu, JH
   Fan, YX
   Ma, YX
   Miura, T
   Kohzuki, M
   Ito, O
AF Xu, Lusi
   Hu, Gaizun
   Qiu, Jiahe
   Fan, Yuxuan
   Ma, Yixuan
   Miura, Takahiro
   Kohzuki, Masahiro
   Ito, Osamu
TI High Fructose-Induced Hypertension and Renal Damage Are Exaggerated in
   Dahl Salt-Sensitive Rats via Renal Renin-Angiotensin System Activation
SO JOURNAL OF THE AMERICAN HEART ASSOCIATION
LA English
DT Article
DE fructose; glomerular hyperfiltration; hypertension; renal damage;
   renin-angiotensin system
ID INDUCED METABOLIC SYNDROME; URIC-ACID; GLOMERULAR HYPERTENSION; CHLORIDE
   REABSORPTION; INSULIN-RESISTANCE; OXIDATIVE STRESS; UP-REGULATION;
   KIDNEY; LOOP; CARBOHYDRATE
AB Background High-fructose diet (HFr) induces hypertension and renal damage. However, it has been unknown whether the HFr-induced hypertension and renal damage are exaggerated in subjects with salt sensitivity. We tested impacts of HFr in Dahl salt-sensitive (DS) and salt-resistant (DR) rats. Methods and Results Male DS and DR rats were fed control diet or HFr (60% fructose) with normal-salt content. After 12 weeks, plasma and urinary parameters, renal histological characteristics, and renal expression of renin-angiotensin system components were examined. Furthermore, effects of renin-angiotensin system inhibitors were also examined in DS rats fed the HFr. HFr elevated blood pressure in DS rats but not in DR rats. HFr increased urinary albumin and liver type fatty acid binding protein excretions in both rats, but the excretions were exaggerated in DS rats. HFr increased plasma lipids and uric acid in both rats, whereas HFr increased creatinine clearance in DS rats but not DR rats. Although HFr decreased plasma renin activity in DS rats, HFr-induced glomerular injury, afferent arteriolar thickening, and renal interstitial fibrosis were exaggerated in DS rats. HFr increased renal expression of angiotensinogen, renin, (pro)renin receptor, angiotensin-converting enzyme, and angiotensin II type 1 receptor in DS rat, whereas HFr increased only angiotensin-converting enzyme expression and decreased renin and angiotensin II type 1 receptor expressions in DR rats. Enalapril and candesartan attenuated the HFr-induced hypertension, albuminuria, glomerular hyperfiltration, and renal damage in DS rats. Conclusion HFr-induced hypertension and renal damage are exaggerated in DS rats via renal renin-angiotensin system activation, which can be controlled by renin-angiotensin system inhibitors.
C1 [Xu, Lusi; Qiu, Jiahe; Fan, Yuxuan; Ma, Yixuan; Miura, Takahiro; Kohzuki, Masahiro; Ito, Osamu] Tohoku Univ, Grad Sch Med, Dept Internal Med & Rehabil Sci, Sendai, Miyagi, Japan.
   [Hu, Gaizun] Virginia Commonwealth Univ, Sch Med, Dept Pharmacol & Toxicol, Richmond, VA USA.
   [Xu, Lusi; Qiu, Jiahe; Fan, Yuxuan; Ma, Yixuan; Miura, Takahiro; Kohzuki, Masahiro; Ito, Osamu] Tohoku Med & Pharmaceut Univ, Fac Med, Div Gen Med & Rehabil, Sendai, Miyagi, Japan.
C3 Tohoku University; Virginia Commonwealth University; Tohoku Medical &
   Pharmaceutical University
RP Ito, O (corresponding author), Tohoku Med & Pharmaceut Univ, Fac Med, Div Gen Med & Rehabil, Miyagino Ku, 1-15-1 Fukumoto, Sendai, Miyagi 9838536, Japan.
EM oito@hosp.tohoku-mpu.ac.jp
RI Miura, Takahiro/ACV-4988-2022
OI Qiu, Jiahe/0000-0002-9716-4890; Ito, Osamu/0000-0001-7583-5270
FU Japan society for the promotion of science KAKENHI [17H0211, 20H04054,
   20H04034]; Grants-in-Aid for Scientific Research [20H04034, 20H04054]
   Funding Source: KAKEN
FX This work was supported by Grants-in-Aid for Scientific Research (Japan
   society for the promotion of science KAKENHI numbers 17H0211, 20H04054,
   and 20H04034).
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NR 45
TC 12
Z9 13
U1 1
U2 8
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2047-9980
J9 J AM HEART ASSOC
JI J. Am. Heart Assoc.
PD JUL 20
PY 2021
VL 10
IS 14
AR e016543
DI 10.1161/JAHA.120.016543
PG 22
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA TL1XZ
UT WOS:000674649600007
PM 34259014
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Moss, JWE
   Williams, JO
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   Michael, DR
   Ramji, DP
AF Moss, Joe W. E.
   Williams, Jessica O.
   Al-Ahmadi, Wijdan
   O'Morain, Victoria
   Chan, Yee-Hung
   Hughes, Timothy R.
   Menendez-Gonzalez, Juan B.
   Almotiri, Alhomidi
   Plummer, Sue F.
   Rodrigues, Neil P.
   Michael, Daryn R.
   Ramji, Dipak P.
TI Protective effects of a unique combination of nutritionally active
   ingredients on risk factors and gene expression associated with
   atherosclerosis in C57BL/6J mice fed a high fat diet†
SO FOOD & FUNCTION
LA English
DT Article
ID LIVER X RECEPTORS; E-DEFICIENT MICE; EICOSAPENTAENOIC ACID; GREEN TEA;
   FISH-OIL; DOCOSAHEXAENOIC ACID; LIPID-PEROXIDATION; OXIDATIVE STRESS;
   PLANT STEROLS; NITRIC-OXIDE
AB Atherosclerosis, an inflammatory disorder of the vasculature and the underlying cause of cardiovascular disease, is responsible for one in three global deaths. Consumption of active food ingredients such as omega-3 polyunsaturated fatty acids, flavanols and phytosterols has many beneficial effects on cardiovascular disease. However, their combined actions on the risk factors for atherosclerosis remains poorly understood. We have previously shown that a formulation containing each of these active components at physiologically relevant doses modulated several monocyte/macrophage processes associated with atherosclerosis in vitro, including inhibition of cytokine-induced pro-inflammatory gene expression, chemokine-driven monocyte migration, expression of M1 phenotype markers, and promotion of cholesterol efflux. The objectives of the present study were to investigate whether the protective actions of the formulation extended in vivo and to delineate the potential underlying mechanisms. The formulation produced several favourable changes, including higher plasma levels of HDL and reduced levels of macrophages and myeloid-derived suppressor cells in the bone marrow. The mRNA expression of liver-X-receptor-alpha, peroxisome proliferator-activated receptor-gamma and superoxide dismutase-1 was induced in the liver and that of interferon-gamma and the chemokine (C-X-C motif) ligand 1 decreased, thereby suggesting the potential mechanisms for many beneficial effects. Other changes were also observed such as increased plasma levels of triglycerides and lipid peroxidation that may reflect potential activation of brown fat. This study provides new insights into the protective actions and the potential underlying mechanisms of the formulation in vivo, particularly in relation to risk factors together with changes in systemic inflammation and hepatic lipid alterations associated with atherosclerosis and metabolic syndrome, and supports further assessments in human trials.
C1 [Moss, Joe W. E.; Williams, Jessica O.; Al-Ahmadi, Wijdan; O'Morain, Victoria; Chan, Yee-Hung; Ramji, Dipak P.] Cardiff Univ, Cardiff Sch Biosci, Sir Martin Evans Bldg,Museum Ave, Cardiff CF10 3AX, Wales.
   [Hughes, Timothy R.] Cardiff Univ, Syst Immun Res Inst, Sch Med, Cardiff CF14 4XN, Wales.
   [Menendez-Gonzalez, Juan B.; Almotiri, Alhomidi; Rodrigues, Neil P.] Cardiff Univ, European Canc Stem Cell Res Inst, Cardiff Sch Biosci, Hadyn Ellis Bldg,Maindy Rd, Cardiff CF24 4HQ, Wales.
   [Plummer, Sue F.; Michael, Daryn R.] Cultech Ltd, Unit 2 Christchurch Rd,Baglan Ind Pk, Port Talbot SA12 7BZ, Wales.
C3 Cardiff University; Cardiff University; Cardiff University
RP Ramji, DP (corresponding author), Cardiff Univ, Cardiff Sch Biosci, Sir Martin Evans Bldg,Museum Ave, Cardiff CF10 3AX, Wales.
EM Ramji@Cardiff.ac.uk
RI Al-Ahmadi, Wijdan/JAI-9721-2023; Almotiri, Alhomidi/GZL-0047-2022
OI Almotiri, Alhomidi/0000-0002-5906-6544; Williams,
   Jessica/0000-0003-4825-4782; Menendez Gonzalez, Juan
   Bautista/0000-0002-0161-4042; Chan, Yee-Hung/0000-0003-3967-6836;
   Alahmadi, Wijdan/0000-0001-9663-3838; Rodrigues,
   Neil/0000-0002-1925-7733
FU School of Biosciences, Cardiff University; Cultech Ltd; Knowledge
   Economy Skills Scholarship; British Heart Foundation [PG/16/25/32097,
   FS/17/75/33257]
FX JWEM PhD was funded by a joint studentship from the School of
   Biosciences, Cardiff University and Cultech Ltd; VO was recipient of a
   Knowledge Economy Skills Scholarship; and JOW and YHC were funded by
   project grant (PG/16/25/32097) and PhD Studentship (FS/17/75/33257)
   respectively from the British Heart Foundation awarded to DPR.
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NR 67
TC 13
Z9 13
U1 0
U2 13
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PD APR 21
PY 2021
VL 12
IS 8
BP 3657
EP 3671
DI 10.1039/d0fo02867c
EA MAR 2021
PG 15
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA RS9EI
UT WOS:000635274300001
PM 33900312
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Mohamed, SH
   Shahat, AA
   Mohamed, MR
   Khalil, WKB
   Salem, AM
   Farrag, ARH
   Ahmed, HH
AF Mohamed, Safaa H.
   Shahat, Abdelaaty A.
   Mohamed, Mohamed R.
   Khalil, Wagdy K. B.
   Salem, Ahmed M.
   Farrag, Abdel Razik H.
   Ahmed, Hanaa H.
TI Camellia sinesis leaves extract ameliorates high fat diet-induced
   nonalcoholic steatohepatitis in rats: analysis of potential mechanisms
SO JOURNAL OF PHARMACEUTICAL INVESTIGATION
LA English
DT Article
DE Nonalcoholic steatohepatitis; Camellia sinensis; Hyperlipidemia;
   Inflammation; Rats
ID GREEN TEA EXTRACT; NECROSIS-FACTOR-ALPHA; SOLUBLE CD40 LIGAND;
   LIVER-DISEASE; OXIDATIVE STRESS; GENE-EXPRESSION; CHOLESTEROL
   DETERMINATION; METABOLIC SYNDROME; BINDING PROTEIN; MESSENGER-RNA
AB Purpose Our research aims to address and determine the effect of Camellia sinensis extract in the management of nonalcoholic steatohepatitis (NASH) in rats. Methods Forty adult female albino rats were divided into four groups. Group 1 (G1) served as the control group, while the other three groups received high-fat diet for 32 weeks to induce NASH and then were later assigned to the following groups: (G2) NASH-afflicted group which was left untreated, (G3) NASH-afflicted group treated with Camellia sinensis extract in a dose of 400 mg/kg, and (G4) NASH-afflicted group treated with Camellia sinensis extract in a dose of 200 mg/kg. Results Significant elevation in serum alanine aminotransferase, albumin, bilirubin (total and direct), cholesterol, low density lipoprotein, triglycerides, leptin, Cox-2, and CD40 values was recorded. Moreover, overexpression of hepatic tumor necrosis factor alpha and hepatocyte growth factor genes were recorded, whereas blood platelet count and serum high density lipoprotein concentration revealed significant depletion, which was paralleled by significant downregulation of hepatic adiponectin gene expression level in NASH group versus the control group. On the opposite side, treatment of NASH groups with two different doses of Camellia sinensis extract reversed the values of the measured biochemical parameters and the targeted gene expression levels when compared with the NASH group. Optical micrograph of liver tissue sections of rats treated with Camellia sinensis extract showed the observed improvement in the studied biochemical and genetic markers. Conclusion This study provides a clear evidence for the promising therapeutic potential of Camellia sinensis extract against NASH. This could be ascribed to its hepatoprotective activity, hypolipidemic effect, and anti-inflammatory potency.
C1 [Mohamed, Safaa H.; Ahmed, Hanaa H.] Natl Res Ctr, Hormones Dept, Div Med Res, Giza, Egypt.
   [Shahat, Abdelaaty A.] Natl Res Ctr, Phytochem Dept, Ind & Pharmaceut Res Div, Giza, Egypt.
   [Mohamed, Mohamed R.; Salem, Ahmed M.] Ain Shams Univ, Fac Sci, Dept Biochem, Cairo, Egypt.
   [Khalil, Wagdy K. B.] Natl Res Ctr, Dept Cell Biol, Biotechnol & Genet Engn Div, Giza, Egypt.
   [Farrag, Abdel Razik H.] Natl Res Ctr, Dept Pathol, Div Med Res, Giza, Egypt.
C3 Egyptian Knowledge Bank (EKB); National Research Centre (NRC); Egyptian
   Knowledge Bank (EKB); National Research Centre (NRC); Egyptian Knowledge
   Bank (EKB); Ain Shams University; Egyptian Knowledge Bank (EKB);
   National Research Centre (NRC); Egyptian Knowledge Bank (EKB); National
   Research Centre (NRC)
RP Mohamed, SH (corresponding author), Natl Res Ctr, Hormones Dept, Div Med Res, Giza, Egypt.
EM rise_sun_1982@hotmail.com
RI Mohamed, Mohamed/V-9143-2019; Shahat, Abdelaaty/C-4100-2011; Khalil,
   Wagdy/IQR-9884-2023
OI Shahat, Abdelaaty/0000-0003-0456-3196; Mohamed, Mohamed
   Ragaa/0000-0002-9269-3128
FU National Research Centre thesis fund [7/5/1]
FX This study was funded by National Research Centre thesis fund (Grant
   Number 7/5/1).
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NR 96
TC 4
Z9 4
U1 0
U2 4
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 2093-5552
EI 2093-6214
J9 J PHARM INVEST
JI J. Pharm. Investig.
PD MAR
PY 2021
VL 51
IS 2
BP 183
EP 197
DI 10.1007/s40005-020-00500-0
EA JAN 2021
PG 15
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA QQ5LD
UT WOS:000604243400002
DA 2025-06-11
ER

PT J
AU Khorasaniha, R
   Siassi, F
   Khajehnasiri, F
   Qorbani, M
   Sotoudeh, G
AF Khorasaniha, Reihane
   Siassi, F.
   Khajehnasiri, F.
   Qorbani, M.
   Sotoudeh, G.
TI Dietary patterns in relation to inflammation in shift workers
SO BMJ MILITARY HEALTH
LA English
DT Article
DE dietary pattern; eat; inflammation; shift worker
ID PHYSICAL-ACTIVITY QUESTIONNAIRE; GRADE SYSTEMIC INFLAMMATION;
   TRANS-FATTY-ACIDS; OXIDATIVE STRESS; METABOLIC SYNDROME; NUTRIENT
   INTAKE; VITAMIN-C; MARKERS; RISK; BIOMARKERS
AB Introduction Rotational shift work has a considerable effect on immune function and cause inflammation. In addition, it may lead to unhealthy dietary intake. No earlier study has examined the association between dietary patterns and inflammation in rotational shift workers. Therefore, this study was conducted to investigate the association between dietary patterns and circulating proinflammatory cytokines among shift workers. Methods This cross-sectional study was conducted among 257 male shift workers. Dietary intake of participants was examined using the semiquantitative Food Frequency Questionnaire. Serum concentrations of interleukin-6 (IL-6), tumour necrosis factor-alpha (TNF-alpha) and high sensitivity C-reactive protein (hs-CRP) were measured using suitable commercial kits. Results Three main dietary patterns included green vegetables, yellow vegetables and cruciferous vegetables (VEG), liquid oils and mayonnaise, fast food and eggs (LFE), as well as tea and coffee, refined grains and spice (TRS). Subjects with the highest adherence to VEG dietary pattern had a significantly lower concentration of IL-6 (p<0.01) and TNF-alpha (p<0.001) as compared with those with the lowest adherence. On the other hand, a significant negative association was found between LFE dietary pattern and serum concentrations of IL-6 (p=0.01) and TNF-alpha (p=0.02). However, no significant association was found between adherence to VEG (p=0.34) or LFE (p=0.99) dietary patterns and levels of hs-CRP and between adherence to TRS dietary pattern and any of the inflammatory cytokines. Conclusion Adherence to VEG and LFE dietary patterns was inversely and directly associated to serum IL-6 and TNF-alpha concentrations in shift workers, respectively. However, no significant association was found between adherence to these two dietary patterns and serum hs-CRP concentrations and between TRS dietary pattern and any of the inflammatory cytokines.
C1 [Khorasaniha, Reihane; Siassi, F.; Sotoudeh, G.] Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Community Nutr, Tehran 1416753955, Iran.
   [Khajehnasiri, F.] Univ Tehran Med Sci, Sch Med, Dept Social Med, Tehran, Iran.
   [Qorbani, M.] Alborz Univ Med Sci, Noncommunicable Dis Res Ctr, Karaj, Iran.
C3 Tehran University of Medical Sciences; Tehran University of Medical
   Sciences; Alborz University of Medical Sciences
RP Siassi, F; Sotoudeh, G (corresponding author), Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Community Nutr, Tehran 1416753955, Iran.
EM siassif@tums.ac.ir; gsotodeh@tums.ac.ir
RI Khajehnasiri, Farahnaz/AAW-6599-2020; Qorbani, Mostafa/M-8171-2017;
   Sotoudeh, Gity/E-3973-2018
OI khorasaniha, reihane/0000-0001-9580-2353; Sotoudeh,
   Gity/0000-0001-6541-2581
FU Tehran University of Medical Sciences and Health Services
   [30331-161-03-94]
FX This research was supported by Tehran University of Medical Sciences and
   Health Services Grant No 30331-161-03-94.
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NR 50
TC 4
Z9 4
U1 0
U2 5
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2633-3767
EI 2633-3775
J9 BMJ MILITARY HEALTH
JI BMJ Military Health
PD AUG
PY 2020
VL 166
IS 4
BP 221
EP 226
DI 10.1136/jramc-2018-001119
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA ND2MB
UT WOS:000561738200003
PM 30765608
DA 2025-06-11
ER

PT J
AU de Oliveira, LCS
   Telles, PVN
   Sousa, JFRE
   Cavalcante, AKM
   Wong, DVT
   Lima, RC
   Torres-Leal, FL
   dos Santos, AA
   da Silva, MTB
AF Santos de Oliveira, Leda Castro
   Nogueira Telles, Pedro Victor
   Reis e Sousa, Jessica Fernanda
   Martins Cavalcante, Ana Karolina
   Tenazoa Wong, Deysi Viviana
   Lima-Junior, Roberto Cesar
   Torres-Leal, Francisco Leonardo
   dos Santos, Armenio Aguiar
   Bento da Silva, Moises Tolentino
TI Influence of the physical exercise on decrease in the gastric emptying
   and alter appetite and food behavior in rats dexamethasone-treatment
SO PHYSIOLOGY & BEHAVIOR
LA English
DT Article
DE Feeding behavior; Dexamethasone; Exercise; Gastric emptying;
   Hyperglycemia
ID INSULIN-RESISTANCE; GLUCOSE-INTOLERANCE; METABOLIC SYNDROME; MUSCLE
   ATROPHY; HYPERGLYCEMIA; HYPOTHALAMUS; PATHWAYS; TRANSIT; STRESS; ALPHA
AB The chronic use of Dexamethasone (Dex) induced hyperglycemia and insulin resistance. On the other hand, physical exercise attenuates the symptoms induced by Dex in many physiological systems. However, the effect of the exercise on the changes in gastric motility induced by dexamethasone remains unknown. We hypothesized that low-intensity aerobic exercise modulates the metabolic effects induced by Dex-treatment by modifying the gastrointestinal function and feeding behavior in rats. Male rats were distributed into the following groups: Control (Ctrl), Dex (1.0 mg/kg, i.p.), Exercise (Ctrl + Exercise 5%) and (Dex1.0 + Exercise 5%). The exercise protocol was swimming for 5 consecutive days. We assessed the murinometric and nutritional indices, food intake, blood glucose by (ipGTT) and the gastric emptying rate of a liquid test meal were assessed in all rats. We observed a significant decrease (p < .05) in the gastric emptying in Dex1.0 group in relation to Ctrl group. The exercise prevented decrease in the gastric emptying (p < .05) in Dex1.0 + EX5% group when compared with Dex1.0 groups. The Dex1.0 group induced a significantly increase (p < .05) in glycaemia vs Ctrl group. The hyperglycemia was improving (p < .05) in the Dex1.0 + Ex5% compared with Dex1.0 groups. We observed a positive correlation (p < .05, and r = 0.7065) between gastric retention vs glycaemia in the Dex1.0 groups. The Dex1.0 reduced (p < .05) the body weight and altered body composition, promoting hypophagia. IL-6 increased (p < .05) at gastric fundus in Ex5% compared with Ctrl groups. In conclusion, the use of Dex1.0 decreases gastric emptying, promotes hyperglycemia and modifies feeding behavior. The low-intensity exercise prevents hyperglycemia, thus improving gastric dysmotility without improving the anthropometric parameters.
C1 [Santos de Oliveira, Leda Castro; Torres-Leal, Francisco Leonardo; Bento da Silva, Moises Tolentino] Univ Fed Piaui, Grad Program Food & Nutr, Teresina, PI, Brazil.
   [Nogueira Telles, Pedro Victor; Reis e Sousa, Jessica Fernanda; Bento da Silva, Moises Tolentino] Univ Fed Piaui, Dept Phys Educ, Teresina, PI, Brazil.
   [Martins Cavalcante, Ana Karolina; dos Santos, Armenio Aguiar] Univ Fed Ceara, Grad Program Med Sci, Fortaleza, CE, Brazil.
   [Tenazoa Wong, Deysi Viviana; Lima-Junior, Roberto Cesar; dos Santos, Armenio Aguiar] Univ Fed Ceara, Sch Med, Dept Physiol & Pharmacol, Fortaleza, CE, Brazil.
   [Torres-Leal, Francisco Leonardo; Bento da Silva, Moises Tolentino] Univ Fed Piaui, Grad Program Pharmacol, Teresina, PI, Brazil.
C3 Universidade Federal do Piaui; Universidade Federal do Piaui;
   Universidade Federal do Ceara; Universidade Federal do Ceara;
   Universidade Federal do Piaui
RP da Silva, MTB (corresponding author), Univ Fed Piaui, Dept Phys Educ, Lab Exercise & Gastrointestinal Tract, Ctr Hlth Sci, Teresina, PI, Brazil.
EM tolentino@ufpi.edu.br
RI Wong, Deysi/AAH-3575-2020; Alves dos Santos, Angela/JNS-9839-2023;
   Lima-Júnior, Roberto/W-5095-2019; da Silva, Moisés/AFS-1763-2022; Bento
   da Silva, Moises Tolentino/IQV-1429-2023
OI Torres-Leal, Leonardo/0000-0003-4325-7458; Bento da Silva, Moises
   Tolentino/0000-0002-6178-9880
FU Coordination for Higher Education Personnel Development (Coordenacao de
   Aperfeicoamento de Pessoal de Nivel Superior - CAPES); National Council
   for Scientific and Technological Development (Conselho Nacional de
   Desenvolvimento Cientifico e Tecnologico - CNPq); Ceara State Foundation
   for Scientific and Technological Development (Fundacao Cearense de Apoio
   ao Desenvolvimento Cientifico e Tecnologico - Funcap)
FX The present study is part of the Masters in Sciences dissertation on
   Food and Nutrition presented by L.C.S.O. to the Federal University of
   Piaui, Brazil. It was supported by grants from the Coordination for
   Higher Education Personnel Development (Coordenacao de Aperfeicoamento
   de Pessoal de Nivel Superior - CAPES), the National Council for
   Scientific and Technological Development (Conselho Nacional de
   Desenvolvimento Cientifico e Tecnologico - CNPq), and the Ceara State
   Foundation for Scientific and Technological Development (Fundacao
   Cearense de Apoio ao Desenvolvimento Cientifico e Tecnologico - Funcap).
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NR 50
TC 6
Z9 6
U1 0
U2 20
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0031-9384
J9 PHYSIOL BEHAV
JI Physiol. Behav.
PD OCT 1
PY 2019
VL 209
AR 112610
DI 10.1016/j.physbeh.2019.112610
PG 9
WC Psychology, Biological; Behavioral Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Behavioral Sciences
GA IS6GJ
UT WOS:000482250000020
PM 31299373
DA 2025-06-11
ER

PT J
AU Manolis, TA
   Manolis, AA
   Manolis, AS
AF Manolis, Theodora A.
   Manolis, Antonis A.
   Manolis, Antonis S.
TI Cardiovascular effects of alcohol: A double-edged sword / how to remain
   at the nadir point of the J-Curve?
SO ALCOHOL
LA English
DT Article
DE Alcohol; Ethanol; Cardiovascular disease; Cardioprotection; Myocardial
   infarction; Atrial fibrillation; Stroke; Heart failure; Cardiomyopathy
ID CORONARY-HEART-DISEASE; DOSE-RESPONSE METAANALYSIS; ATRIAL-FIBRILLATION;
   BINGE DRINKING; RISK-FACTORS; ALL-CAUSE; UPDATED METAANALYSIS; METABOLIC
   SYNDROME; OXIDATIVE STRESS; BLOOD-PRESSURE
AB Background: In addition to its established harmful effects on the liver and other organs, heavy alcohol use confers deleterious effects on the cardiovascular (CV) system, as well. However, data have emerged that light/moderate alcohol consumption (1 drink/day for women and 1-2 drinks/day for men) may be protective against CV disease.
   Objective/methods: English articles regarding the CV effects of alcohol/ethanol were reviewed by search in Medline, Scopus, and Google Scholar.
   Results: A J-shaped curve has been proposed to illustrate a differential effect of alcohol on the CV system with the lowest point on the curve (light/moderate drinking) corresponding to optimal exposure to alcohol, which may confer cardioprotection, the rather neutral effect of non-drinking, and the highest risk of heavy and/or binge drinking reflecting the consequence of harmful exposure. However, staying at the nadir of this J-shaped curve appears difficult. Furthermore, concern and distrust have also been raised about the quality of evidence for such "cardioprotection", emphasizing the need for further randomized controlled trials. Another concern relates to the risk of moderate drinking leading to problem drinking, since alcohol is the most common addictive substance.
   Conclusion: Optimal exposure to alcohol (light/moderate use) means that one needs to stay at the nadir of the J-shaped curve for alcohol use to avail oneself of possible cardioprotection, and this may not be an easy thing to accomplish and/or adhere to, especially if one "likes" alcohol drinking. However, the evidence of "cardioprotection" conferred by alcohol has also been refuted, due to lack of randomized controlled trials. (C) 2018 Elsevier Inc. All rights reserved.
C1 [Manolis, Theodora A.] Zakynthos Hosp, Zakynthos, Greece.
   [Manolis, Antonis A.] Univ Patras, Sch Med, Patras, Greece.
   [Manolis, Antonis S.] Athens Univ, Sch Med, Dept Cardiol 3, Vas Sofias 114, Athens 11527, Greece.
C3 University of Patras; National & Kapodistrian University of Athens;
   Athens Medical School
RP Manolis, AS (corresponding author), Athens Univ, Sch Med, Dept Cardiol 3, Vas Sofias 114, Athens 11527, Greece.
EM asm@otenet.gr
RI Manolis, Antonis/F-5003-2014; Manolis, Theodora A./GSI-9370-2022
OI Manolis, Theodora A./0000-0001-7611-0984
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NR 109
TC 30
Z9 32
U1 1
U2 14
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0741-8329
EI 1873-6823
J9 ALCOHOL
JI Alcohol
PD MAY
PY 2019
VL 76
BP 117
EP 129
DI 10.1016/j.alcohol.2018.08.011
PG 13
WC Substance Abuse; Pharmacology & Pharmacy; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Substance Abuse; Pharmacology & Pharmacy; Toxicology
GA IA1HM
UT WOS:000469309900015
PM 30735906
DA 2025-06-11
ER

PT J
AU Ishaq, A
   Schröder, J
   Edwards, N
   von Zglinicki, T
   Saretzki, G
AF Ishaq, A.
   Schroder, J.
   Edwards, N.
   von Zglinicki, T.
   Saretzki, G.
TI Dietary Restriction Ameliorates Age-Related Increase in DNA Damage,
   Senescence and Inflammation in Mouse Adipose Tissuey
SO JOURNAL OF NUTRITION HEALTH & AGING
LA English
DT Article
DE Visceral fat; ageing; dietary restriction; senescence; inflammation
ID ACTIVATED PROTEIN-KINASE; TERM CALORIC RESTRICTION; CELLULAR SENESCENCE;
   MICE; ADIPOCYTES
AB Ageing is associated with redistribution of fat around the body and saturation of visceral adipose depots. Likewise, the presence of excess fat in obesity or during ageing places extra stress on visceral depots, resulting in chronic inflammation and increased senescence. This process can contribute to the establishment of the metabolic syndrome and accelerated ageing. Dietary restriction (DR) is known to alleviate physiological signs of inflammation, ageing and senescence in various tissues including adipose tissue.
   Our pilot study aimed to analyse senescence and inflammation parameters in mouse visceral fat tissue during ageing and by short term, late-onset dietary restriction as a nutritional intervention.
   In this study we used visceral adipose tissue from mice between 5 and 30 months of age and analysed markers of senescence (adipocyte size, gamma H2A.X, p16, p21) and inflammation (e.g. IL-6, TNF alpha, IL-1 beta, macrophage infiltration) using immuno-staining, as well as qPCR for gene expression analysis. Fat tissues from 3 mice per group were analysed.
   We found that the amount of gamma H2A.X foci as well as the expression of senescence and inflammation markers increased during ageing but decreased with short term DR. In contrast, the increase in amounts of single or aggregated macrophages in fat depots occurred only at higher ages. Surprisingly, we also found that adipocyte size as well as some senescence parameters decreased at very high age (30 months).
   Our results demonstrate increased senescence and inflammation during ageing in mouse visceral fat while DR was able to ameliorate several of these parameters as well as increased adipocyte size at 17.5 months of age. This highlights the health benefits of a decreased nutritional intake over a relatively short period of time at middle age.
C1 [Ishaq, A.; Schroder, J.; Edwards, N.; von Zglinicki, T.; Saretzki, G.] Newcastle Inst Ageing, Inst Cell & Mol Biosci, Ageing Biol Ctr, Campus Ageing & Vital, Newcastle Upon Tyne, Tyne & Wear, England.
C3 Newcastle University - UK
RP Saretzki, G (corresponding author), Ageing Biol Ctr, Campus Ageing & Vital,Edwardson Bldg, Newcastle Upon Tyne NE4 5PL, Tyne & Wear, England.; Saretzki, G (corresponding author), Inst Cell & Mol Biosci, Campus Ageing & Vital,Edwardson Bldg, Newcastle Upon Tyne NE4 5PL, Tyne & Wear, England.
EM gabriele.saretzki@ncl.ac.uk
RI von Zglinicki, Thomas/LXV-3399-2024; Saretzki, Gabriele/I-7175-2019
OI von Zglinicki, Thomas/0000-0002-5939-0248; Ishaq,
   Abbas/0000-0001-6344-466X; Edwards, Nicola/0000-0002-7925-2301
FU BBSRC grant [BB/C008200/1]; Newcastle University Institute for Ageing
   [BH161774]; BBSRC [BB/I020748/1, BB/F010966/1] Funding Source: UKRI; MRC
   [MR/L016354/1] Funding Source: UKRI
FX The work was supported by BBSRC grant BB/C008200/1 to TvZ and from a
   Grant from Newcastle University Institute for Ageing (BH161774) to GS
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NR 58
TC 18
Z9 19
U1 0
U2 7
PU SPRINGER FRANCE
PI PARIS
PA 22 RUE DE PALESTRO, PARIS, 75002, FRANCE
SN 1279-7707
EI 1760-4788
J9 J NUTR HEALTH AGING
JI J. Nutr. Health Aging
PD APR
PY 2018
VL 22
IS 4
BP 555
EP 561
DI 10.1007/s12603-017-0968-2
PG 7
WC Geriatrics & Gerontology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology; Nutrition & Dietetics
GA GA5PH
UT WOS:000428385500015
PM 29582897
OA Green Published, Green Accepted, hybrid
DA 2025-06-11
ER

PT J
AU Sogaard, D
   Lindblad, MM
   Paidi, MD
   Hasselholt, S
   Lykkesfeldt, J
   Tveden-Nyborg, P
AF Sogaard, Ditte
   Lindblad, Maiken M.
   Paidi, Maya D.
   Hasselholt, Stine
   Lykkesfeldt, Jens
   Tveden-Nyborg, Pernille
TI In vivo vitamin C deficiency in guinea pigs increases ascorbate
   transporters in liver but not kidney and brain
SO NUTRITION RESEARCH
LA English
DT Article
DE Ascorbic acid [D02.241.511.902.107]; Malnutrition [C18.654.521];
   Deficiency diseases [C18.654.521.500]; Brain [A08.186.211]; Guinea pig
ID OXIDATIVE STRESS; DEHYDROASCORBIC ACID; SVCT2; GLUTATHIONE; BIOMARKERS;
   RETENTION; NEURONS; DIETARY; PLASMA; SERUM
AB Moderate vitamin C (vitC) deficiency (plasma concentrations less than 23 mu mol/L) affects as much as 10% of adults in the Western World and has been associated with an increased mortality in disease complexes such as cardiovascular disease and the metabolic syndrome. The distribution of vitC within the body is subjected to complex and nonlinear pharmacokinetics and largely depends on the sodium-dependent vitC-specific transporters, sodium-dependent vitamin C transporter 1 (SVCT1) and sodium-dependent vitamin C transporter 2 (SVCT2). Although currently not established, it is likely to expect that a state of deficiency may affect the expression of these transporters to preserve vitC concentrations in specific target tissues. We hypothesized that diet-induced states of vitC deficiency lead to alterations in the messenger RNA (mRNA) and/or protein expression of vitC transporters, thereby regulating vitC tissue distribution. Using guinea pigs as a validated model, this study investigated the effects of a diet-induced vitC deficiency (100 mg vitC/kg feed) or depletion (0 mg vitC/kg feed) on the expression of transporters SVCT1 and SVCT2 in selected tissues and the transport from plasma to cerebrospinal fluid (CSF). In deficient animals, SVCT1 was increased in the liver, whereas a decreased SVCT1 expression but increased SVCT2 mRNA in livers of depleted animals suggests a shift in transporter expression as response to the diet. In CSF, a constant plasma:CSF ratio shows unaltered vitC transport irrespective of dietary regime. The study adds novel information to the complex regulation maintaining vitC homeostasis in vivo during states of deficiency. (C) 2014 Elsevier Inc. All rights reserved.
C1 [Sogaard, Ditte; Lindblad, Maiken M.; Paidi, Maya D.; Hasselholt, Stine; Lykkesfeldt, Jens; Tveden-Nyborg, Pernille] Univ Copenhagen, Dept Vet Dis Biol, Fac Hlth & Med Sci, Sect Expt Anim Models, Copenhagen, Denmark.
C3 University of Copenhagen
RP Tveden-Nyborg, P (corresponding author), Univ Copenhagen, Dept Vet Dis Biol, Ridebanevej 9,1 Floor, DK-1870 Frederiksberg C, Denmark.
EM ptn@sund.ku.dk
RI ; Lykkesfeldt, Jens/A-1072-2011
OI Paidi, Maya Devi/0009-0006-5456-097X; Lykkesfeldt,
   Jens/0000-0002-6514-8407; Tveden-Nyborg, Pernille/0000-0002-5574-5742
FU Danish National Research Councils (Ministry of Higher Education and
   Research, Copenhagen, Denmark); The LifePharm Centre for In Vivo
   Pharmacology (Copenhagen, Denmark); University of Copenhagen
FX This project was partially funded by the Danish National Research
   Councils (Ministry of Higher Education and Research, Copenhagen,
   Denmark), The LifePharm Centre for In Vivo Pharmacology (Copenhagen,
   Denmark), and University of Copenhagen.
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NR 30
TC 16
Z9 17
U1 0
U2 16
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0271-5317
J9 NUTR RES
JI Nutr. Res.
PD JUL
PY 2014
VL 34
IS 7
BP 639
EP 645
DI 10.1016/j.nutres.2014.07.004
PG 7
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA AO2CW
UT WOS:000341124100010
PM 25150123
DA 2025-06-11
ER

PT J
AU Duale, N
   Steffensen, IL
   Andersen, J
   Brevik, A
   Brunborg, G
   Lindeman, B
AF Duale, N.
   Steffensen, I. -L.
   Andersen, J.
   Brevik, A.
   Brunborg, G.
   Lindeman, B.
TI Impaired sperm chromatin integrity in obese mice
SO ANDROLOGY
LA English
DT Article
DE gene expression; infertility; obesity; sperm chromatin structure assay
ID BODY-MASS INDEX; HIGH-FAT DIET; INCREASED OXIDATIVE STRESS;
   GENE-EXPRESSION; SEMEN QUALITY; REPRODUCTIVE HORMONES; CYTOCHROME-P450
   2E1; METABOLIC SYNDROME; DNA INTEGRITY; MALE PARTNERS
AB An increased global prevalence of obesity coincides with an apparent decline in male sperm quality and a possible association between these pathologies has been suggested. In this study, we examined the effects of obesity on sperm chromatin integrity using two mouse models of obesity. In one group of mice, obesity was induced by a high-fat diet (HFD) (diet-induced obesity; DIO model), whereas in the other group, leptin deficiency was used to study the effects of obesity independently of the influence of dietary factors. Sperm chromatin integrity is recognized as an important measure of male infertility, and was analysed by the sperm chromatin structure assay. We found increased sperm DNA fragmentation in both groups of obese mice compared to lean mice, whereas the percentage of immature spermatozoa was not increased by obesity. The DIO model reflects the human condition more closely than the leptin-deficient model and was therefore selected for examination of the transcriptional response of a selection of marker genes in the testis by quantitative real-time PCR. The analysis of transcript levels of the selected testicular marker genes showed moderate, but significant, up-regulation of the Cyp2e1, Cyp19a1, Tnf and Pparg genes in DIO mice compared to lean mice. In conclusion, a clear positive correlation between body mass index and sperm DNA fragmentation was found in two mouse models of obesity. However, the variability in sperm DNA fragmentation within the two groups of obese animals was high. The observed changes in the transcript level of the marker genes suggest that there may be a local response in testicular cells to the HFD regimen with a potential impact on intratesticular signalling and spermatogenesis.
C1 [Duale, N.; Steffensen, I. -L.; Andersen, J.; Brunborg, G.; Lindeman, B.] Norwegian Inst Publ Hlth, Div Environm Med, N-0403 Oslo, Norway.
   [Brevik, A.] Oslo & Akershus Univ Coll Appl Sci, Fac Hlth Sci, Oslo, Norway.
C3 Norwegian Institute of Public Health (NIPH); Oslo Metropolitan
   University (OsloMet)
RP Lindeman, B (corresponding author), Norwegian Inst Publ Hlth, Div Environm Med, POB 4404 Nydalen, N-0403 Oslo, Norway.
EM birgitte.lindeman@fhi.no
RI Brunborg, Geir/AAH-3186-2020
FU Research Council of Norway [196112/H10]
FX I-LS was funded by The Research Council of Norway (project no.
   196112/H10). Hege Hjertholm and Tone Rasmussen are thanked for
   genotyping of the mice.
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NR 71
TC 37
Z9 39
U1 0
U2 16
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2047-2919
EI 2047-2927
J9 ANDROLOGY-US
JI Andrology
PD MAR
PY 2014
VL 2
IS 2
BP 234
EP 243
DI 10.1111/j.2047-2927.2013.00178.x
PG 10
WC Andrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA AB3MY
UT WOS:000331696100011
PM 24459046
OA Bronze
DA 2025-06-11
ER

PT J
AU Ferder, M
   Inserra, F
   Manucha, W
   Ferder, L
AF Ferder, Marcelo
   Inserra, Felipe
   Manucha, Walter
   Ferder, Leon
TI The world pandemic of vitamin D deficiency could possibly be explained
   by cellular inflammatory response activity induced by the
   renin-angiotensin system
SO AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
LA English
DT Review
DE oxidative stress; mitochondria; cardiovascular disease; angiotensin
   receptor blocker; vitamin D receptor
ID 3RD NATIONAL-HEALTH; NEGATIVE ENDOCRINE REGULATOR; CARDIOVASCULAR
   RISK-FACTORS; MESSENGER-RNA EXPRESSION; KAPPA-B ACTIVATION; II TYPE-1
   RECEPTOR; CD4(+) T-CELLS; BLOOD-PRESSURE; 1,25-DIHYDROXYVITAMIN D-3;
   PARATHYROID-HORMONE
AB This review attempts to show that there may be a relationship between inflammatory processes induced by chronic overstimulation of the renin-angiotensin system (RAS) and the worldwide deficiency of vitamin D (VitD) and that both disorders are probably associated with environmental factors. Low VitD levels represent a risk factor for several apparently different diseases, such as infectious, autoimmune, neurodegenerative, and cardiovascular diseases, as well as diabetes, osteoporosis, and cancer. Moreover, VitD insufficiency seems to predispose to hypertension, metabolic syndrome, left ventricular hypertrophy, heart failure, and chronic vascular inflammation. On the other hand, inappropriate stimulation of the RAS has also been associated with the pathogenesis of hypertension, heart attack, stroke, and hypertrophy of the left ventricle and vascular smooth muscle cells. Because VitD receptors (VDRs) and RAS receptors are almost distributed in the same tissues, a possible link between VitD and the RAS is even more plausible. Furthermore, from an evolutionary point of view, both systems were developed simultaneously, actively participating in the regulation of inflammatory and immunological mechanisms. Changes in RAS activity and activation of the VDR seem to be inversely related; thus any changes in one of these systems would have a completely opposite effect on the other, making it possible to speculate that the two systems could have a feedback relationship. In fact, the pandemic of VitD deficiency could be the other face of increased RAS activity, which probably causes lower activity or lower levels of VitD. Finally, from a therapeutic point of view, the combination of RAS blockade and VDR stimulation appears to be more effective than either RAS blockade or VDR stimulation individually.
C1 [Ferder, Marcelo] Univ Buenos Aires, Fac Med, Buenos Aires, DF, Argentina.
   [Inserra, Felipe] Univ Austral, Fac Ciencias Biomed, Buenos Aires, DF, Argentina.
   [Manucha, Walter] Univ Nacl Cuyo, Sch Med, Pathophysiol & Pharmacol Dept, RA-5500 Mendoza, Argentina.
   [Ferder, Leon] Ponce Sch Med & Hlth Sci, Dept Physiol & Pharmacol, Ponce, PR 00732 USA.
C3 University of Buenos Aires; Austral University; University Nacional Cuyo
   Mendoza
RP Ferder, M (corresponding author), Ponce Sch Med & Hlth Sci, Dept Physiol & Pharmacol, POB 7004, Ponce, PR 00732 USA.
EM leferder@psm.edu
OI Manucha, Walter/0000-0002-2279-7626
FU National Center for Research Resources Grant [G12 RR-003050]; National
   Institute on Minority Health and Health Disparities Grant [8G12
   MD-007579]
FX The authors thank Yma Tomassini and Bob Ritchie (National Center for
   Research Resources Grant G12 RR-003050/National Institute on Minority
   Health and Health Disparities Grant 8G12 MD-007579) for help with
   editing the manuscript.
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NR 182
TC 105
Z9 112
U1 0
U2 26
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0363-6143
EI 1522-1563
J9 AM J PHYSIOL-CELL PH
JI Am. J. Physiol.-Cell Physiol.
PD JUN
PY 2013
VL 304
IS 11
BP C1027
EP C1039
DI 10.1152/ajpcell.00403.2011
PG 13
WC Cell Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Physiology
GA 156FJ
UT WOS:000319806900001
PM 23364265
OA Green Published
DA 2025-06-11
ER

PT J
AU Valera, B
   Muckle, G
   Poirier, P
   Jacobson, SW
   Jacobson, JL
   Dewailly, E
AF Valera, Beatriz
   Muckle, Gina
   Poirier, Paul
   Jacobson, Sandra W.
   Jacobson, Joseph L.
   Dewailly, Eric
TI Cardiac autonomic activity and blood pressure among Inuit children
   exposed to mercury
SO NEUROTOXICOLOGY
LA English
DT Article
DE Methylmercury; Blood pressure; Heart rate variability; n-3 fatty acids;
   Inuit; Children
ID HEART-RATE-VARIABILITY; PRENATAL METHYLMERCURY EXPOSURE; TRACE-ELEMENTS
   INTAKE; POLYCHLORINATED-BIPHENYLS; METABOLIC SYNDROME;
   CIGARETTE-SMOKING; OXIDATIVE STRESS; SYMPATHETIC TONE; NATIONAL-HEALTH;
   FAROE-ISLANDS
AB Background: Studies conducted in the Faeroe Islands and Japan suggest a negative impact of mercury on heart rate variability (HRV) among children while the results regarding blood pressure (BP) are less consistent.
   Objective: To assess the impact of mercury on HRV and BP among Nunavik Inuit children.
   Methods: A cohort of 226 children was followed from birth to 11 years old. Mercury concentration in cord blood and in blood and hair at 11 years old were used as markers of prenatal and childhood exposure, respectively. HRV was measured using ambulatory 2 h-Holter monitoring while BP was measured through a standardized protocol. Simple regression was used to assess the relationship of mercury to BP and HRV parameters. Multiple linear regressions were performed adjusting for covariates such as age, sex, birth weight, body mass index (BMI), height, total n-3 fatty acids, polychlorinated biphenyls (PCB 153), lead, selenium and maternal smoking during pregnancy.
   Results: Median cord blood mercury and blood mercury levels at 11 years old were 81.5 nmoL/L (IQR: 45.0-140.0) and 14.5 nmol/L (IQR: 7.5-28.0), respectively. After adjusting for the covariates, child blood mercury was associated with low frequency (LF) (beta = -0.21, p = 0.05), the standard deviation of R-R intervals (SDNN) (beta = -0.26, p = 0.02), the standard deviation of R-R intervals measured over 5 min periods (SDANN)(beta = -0.31. p = 0.01) and the coefficient of variation of R-R intervals (CVRR) (beta = -0.06, p = 0.02). No significant association was observed with BP.
   Conclusion: Mercury exposure during childhood seems to affect HRV among Nunavik Inuit children at school age. (C) 2012 Elsevier Inc. All rights reserved.
C1 [Valera, Beatriz; Muckle, Gina; Dewailly, Eric] CHUQ Med Res Ctr, Quebec City, PQ, Canada.
   [Muckle, Gina] Univ Laval, Sch Psychol, Quebec City, PQ, Canada.
   [Poirier, Paul] Laval Hosp, Res Ctr, Quebec Heart & Lung Inst, Quebec City, PQ, Canada.
   [Poirier, Paul] Univ Laval, Fac Pharm, Quebec City, PQ, Canada.
   [Jacobson, Sandra W.; Jacobson, Joseph L.] Wayne State Univ, Sch Med, Dept Psychiat & Behav Neurosci, Detroit, MI USA.
   [Jacobson, Joseph L.] Wayne State Univ, Sch Med, Dept Obstet & Gynecol, Detroit, MI 48201 USA.
   [Dewailly, Eric] Univ Laval, Dept Prevent & Social Med, Quebec City, PQ, Canada.
C3 Laval University; Laval University Hospital; Laval University; Quebec
   Heart & Lung Institute; Laval University; Wayne State University; Wayne
   State University; Laval University
RP Dewailly, E (corresponding author), Ctr Rech CHUQ, 2875 Blvd Laurier,Edifice Delta 2,Bur 600, Quebec City, PQ G1V 2M2, Canada.
EM eric.dewailly@crchul.ulaval.ca
RI Muckle, Gina/KHZ-3117-2024; Poirier, Paul/KFS-2253-2024
OI Muckle, Gina/0000-0001-9632-5755
FU Indian and Northern Affairs Canada; NIH/National Institute of
   Environmental Health and Sciences; Health Canada; March of Dimes Birth
   Defect Foundation; FRSQ-Hydro-Quebec; Joseph Young, Sr. Fund from the
   State of Michigan; Nunavik Regional Board of Health and Social Services;
   FRSQ; Nasivvik Centre for Inuit Health and Changing Environments
FX We are grateful to the Nunavik population for their participation in
   this study and to the medical and health care professionals from the
   health centers and nursing stations for their assistance. This research
   was funded by annual grants from Indian and Northern Affairs Canada
   (Northern Contaminants Program) and grants from the NIH/National
   Institute of Environmental Health and Sciences, Health Canada, March of
   Dimes Birth Defect Foundation, FRSQ-Hydro-Quebec, the Joseph Young, Sr.
   Fund from the State of Michigan, and Nunavik Regional Board of Health
   and Social Services. Paul Poirier is a senior clinician-research scholar
   from the FRSQ. Beatriz Valera is supported by doctoral grants from the
   FRSQ and from the Nasivvik Centre for Inuit Health and Changing
   Environments.
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NR 57
TC 56
Z9 58
U1 0
U2 31
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0161-813X
EI 1872-9711
J9 NEUROTOXICOLOGY
JI Neurotoxicology
PD OCT
PY 2012
VL 33
IS 5
BP 1067
EP 1074
DI 10.1016/j.neuro.2012.05.005
PG 8
WC Neurosciences; Pharmacology & Pharmacy; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Toxicology
GA 028BA
UT WOS:000310396600011
PM 23227484
DA 2025-06-11
ER

PT J
AU Ota, H
   Tamaki, S
   Itaya-Hironaka, A
   Yamauchi, A
   Sakuramoto-Tsuchida, S
   Morioka, T
   Takasawa, S
   Kimura, H
AF Ota, Hiroyo
   Tamaki, Shinji
   Itaya-Hironaka, Asako
   Yamauchi, Akiyo
   Sakuramoto-Tsuchida, Sumiyo
   Morioka, Takashi
   Takasawa, Shin
   Kimura, Hiroshi
TI Attenuation of glucose-induced insulin secretion by intermittent hypoxia
   via down-regulation of CD38
SO LIFE SCIENCES
LA English
DT Article
DE Sleep apnea syndrome; Intermittent hypoxia; Glucose-induced insulin
   secretion; Cyclic ADP-ribose; CD38
ID CYCLIC ADP-RIBOSE; OBSTRUCTIVE SLEEP-APNEA; BETA-CELL REGENERATION;
   DIABETES-MELLITUS; AIRWAY HYPERRESPONSIVENESS; METABOLIC SYNDROME;
   PANCREATIC-ISLETS; GENE PROTEIN; IN-VITRO; AUTOANTIBODIES
AB Aims: Sleep apnea syndrome (SAS) is characterized by recurrent episodes of oxygen desaturation during sleep, the development of daytime sleepiness, and deterioration in the quality of life. Accumulating evidence suggests the association of intermittent hypoxia (IH), a hallmark of SAS, and type 2 diabetes independently on body mass index and waist circumference. In addition to insulin resistance, the progression to type 2 diabetes is dependent on the impairment of glucose-induced insulin secretion (GIS) from pancreatic beta-cells. However, the direct effects of IH on GIS are elusive.
   Main methods: HIT-T15 hamster beta-cells and isolated rat islets were exposed to 64 cycles/24 h of IH (5 min hypoxia/10 min normoxia) or normoxia for 24 h. Changes of GIS and gene expression in IH-treated beta-cells were analyzed by ELISA and real-time RT-PCR, respectively.
   Key findings: After IH treatment, GIS both from IH-treated HIT-T15 cells and isolated rat islets were significantly attenuated. The level of insulin mRNA was unchanged by IH. The mRNA levels of glucose transporter 2 (Glut2), glucokinase (GK), sulfonylurea receptor1 (SUR1), and L-type Ca2+ channel1.2 (Cav1.2) in IH-treated-islets were similar to those in normoxia-treated islets. In contrast, the mRNA level of CD38 in IH-treated islets was significantly lower than that in normoxia-treated islets. The reporter gene assay revealed that the transcription of CD38 was attenuated by IH, and the transfection of CD38 expression vector recovered the attenuation of GIS by IH.
   Significance: These results indicate that IH stress directly attenuates GIS from beta-cells via the down-regulation of CD38. (c) 2011 Elsevier Inc. All rights reserved.
C1 [Ota, Hiroyo; Tamaki, Shinji; Morioka, Takashi; Kimura, Hiroshi] Nara Med Univ, Dept Internal Med 2, Kashihara, Nara 6348521, Japan.
   [Itaya-Hironaka, Asako; Yamauchi, Akiyo; Sakuramoto-Tsuchida, Sumiyo; Takasawa, Shin] Nara Med Univ, Dept Biochem, Kashihara, Nara 6348521, Japan.
C3 Nara Medical University; Nara Medical University
RP Kimura, H (corresponding author), Nara Med Univ, Dept Internal Med 2, 840 Shijo Cho, Kashihara, Nara 6348522, Japan.
EM kimura@nmu-gw.naramed-u.ac.jp
FU Ministry of Education, Culture, Sports, Science and Technology, Japan
   [19390226]; Ministry of Health, Labour and Welfare, Japan; Grants-in-Aid
   for Scientific Research [22591096, 23659161, 19390226] Funding Source:
   KAKEN
FX This work was supported in part by Grants-in-Aid for Scientific Research
   (B) (19390226) from the Ministry of Education, Culture, Sports, Science
   and Technology, Japan, and by a grant to the Respiratory Failure
   Research Group from the Ministry of Health, Labour and Welfare, Japan.
   We are grateful to Dr. Yoshiko Dohi, Nara Medical University for kind
   help. This work is in partial fulfillment by H. O. of the degree of
   Doctor of Medical Science at Nara Medical University.
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NR 43
TC 60
Z9 60
U1 0
U2 9
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0024-3205
J9 LIFE SCI
JI Life Sci.
PD JAN 30
PY 2012
VL 90
IS 5-6
BP 206
EP 211
DI 10.1016/j.lfs.2011.11.011
PG 6
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA 988JV
UT WOS:000307487400006
PM 22154909
DA 2025-06-11
ER

PT J
AU Valenti, L
   Rametta, R
   Dongiovanni, P
   Maggioni, M
   Fracanzani, AL
   Zappa, M
   Lattuada, E
   Roviaro, G
   Fargion, S
AF Valenti, Luca
   Rametta, Raffaela
   Dongiovanni, Paola
   Maggioni, Marco
   Fracanzani, Anna Ludovica
   Zappa, Marco
   Lattuada, Enzo
   Roviaro, Giancarlo
   Fargion, Silvia
TI Increased expression and activity of the transcription factor FOX01 in
   nonalcoholic steatohepatitis
SO DIABETES
LA English
DT Article
ID FATTY LIVER-DISEASE; HEPATIC INSULIN-RESISTANCE; GLUCOSE-PRODUCTION;
   FACTOR FOXO1; METABOLIC SYNDROME; CONTROLLED-TRIAL; PROTEIN;
   GLUCONEOGENESIS; PGC-1-ALPHA; SENSITIVITY
AB OBJECTIVE - Nonalocholic fatty liver, affecting 34% of the U. S. population, is characterized by hepatic insulin resistance, which is more marked in the presence of steatolrepatitis, and frequently precedes hyperglycenria. The molecular mechanisms underlying the relationship between fatty liver and insulin resistance are still undergoing definition and have not been evaluated in humans. Our aim was to evaluate the relationship between insulin resistance and the expression and regulation of forkhead box-containing protein 0 subfamily-1 (FOXO 1), a transcription factor that mediates the effect of insulin on the gluconeogenic genes PEPCK and glucose-6-phosphatase catalytic subunit (G6PC).
   RESEARCH DESIGN AND METHODS-FOXOI, PEPCK, and G6PC mRNA levels were evaluated in 84 subjects: 26 with steatoliepatitis, 28 with steatosis alone, 14 with normal liver histology without metabolic alterations, and 16 with hepatitis C virus chronic hepatitis, of whom 8 were with and 8 were without steatosis. Protein expression and regulation of FOXO1 and upstream insulin signaling were analyzed in a subset.
   RESULTS-Expression of PEPCK was higher in steatolrepatitis compared with steatosis alone and normal liver, and it was correlated with the homeostasis model assessment of insulin resistance (HOMA-IR) index. FOXO 1 mRNA levels were higher in steatohepatitis, correlated with PEPCK and G6PC mRNA and with HOMA-IR. FOXO1 upregulation was confirmed at protein levels in steatoliepatitis and, in the presence of oxidative stress, was associated with decreased Ser(256) phosphorylation, decreased Akt1, and increased Jun NH2-terminal kinase-1 activity. Consistently, immurrohistochemistry showed increased FOXO1 expression and nuclear localization in steatolrepatitis. FOXO1 mRNA levels correlated with nonalcoholic steatoliepatitis activity score and were modulated by drugs counteracting hepatic lipogenesis.
   CONCLUSIONS-FOXO1 expression and activity are increased in patients with steatolrepatitis, and mRNA levels are correlated with hepatic insulin resistance.
C1 [Valenti, Luca; Rametta, Raffaela; Dongiovanni, Paola; Fracanzani, Anna Ludovica; Fargion, Silvia] Univ Milan, Dept Internal Med, Osped Maggiore, Policlin Mangiagalli & Regina Elena IRCCS, I-20122 Milan, Italy.
   [Maggioni, Marco] Hosp San Paolo, Dept Pathol, Milan, Italy.
   [Zappa, Marco; Lattuada, Enzo; Roviaro, Giancarlo] Univ Milan, Dept Surg, Osped Maggiore, Policlin Mangiagalli & Regina Elena IRCCS, I-20122 Milan, Italy.
C3 IRCCS Ca Granda Ospedale Maggiore Policlinico; University of Milan;
   IRCCS Ca Granda Ospedale Maggiore Policlinico; University of Milan
RP Fargion, S (corresponding author), Univ Milan, Dept Internal Med, UO Med Interna IB, Fdn Policlin Mangiagalli & Regina Elena IRCCS, Via F Sforza 35, I-20122 Milan, Italy.
EM silvia.fargion@unimi.it
RI Dongiovanni, Paola/AAC-9965-2019; zappa, marco/AAB-3294-2019; Valenti,
   Luca/B-3695-2009; Maggioni, Marco/AAC-4617-2022; Fracanzani, Anna
   Ludovica/J-8986-2018
OI rametta, raffaela/0000-0003-0091-9394; Valenti,
   Luca/0000-0001-8909-0345; Dongiovanni, Paola/0000-0003-4343-7213;
   Maggioni, Marco/0000-0001-8603-8998; Fracanzani, Anna
   Ludovica/0000-0001-5918-0171
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NR 42
TC 147
Z9 166
U1 2
U2 12
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0012-1797
EI 1939-327X
J9 DIABETES
JI Diabetes
PD MAY
PY 2008
VL 57
IS 5
BP 1355
EP 1362
DI 10.2337/db07-0714
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 297PN
UT WOS:000255628700027
PM 18316359
OA Bronze
DA 2025-06-11
ER

PT J
AU Armstrong, K
   Rakhit, D
   Jeffriess, L
   Johnson, D
   Leano, R
   Prins, J
   Garske, L
   Marwick, T
   Isbel, N
AF Armstrong, Kirsten
   Rakhit, Dhrubo
   Jeffriess, Leanne
   Johnson, David
   Leano, Rodel
   Prins, John
   Garske, Luke
   Marwick, Thomas
   Isbel, Nicole
TI Cardiorespiratory fitness is related to physical inactivity, metabolic
   risk factors, and atherosclerotic burden in glucose-intolerant renal
   transplant recipients
SO CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
LA English
DT Article
ID CORONARY-HEART-DISEASE; EXERCISE CAPACITY; CAROTID ATHEROSCLEROSIS;
   DIABETES-MELLITUS; AEROBIC FITNESS; MEN; MORTALITY; HEMODIALYSIS;
   PREVALENCE; PREDICTORS
AB The mechanisms of reduced cardiorespiratory fitness (CF) in renal transplant recipients (RTR) have not been studied closely. This study evaluated the relationships between CF and specific cardiovascular risk factors (metabolic syndrome [MS], physical inactivity, myocardial ischemia, and atherosclerotic burden) in glucose-intolerant RTR. Data were recorded on 71 glucose-intolerant RTR (mean age 55 yr; 55% male; median transplant duration 5.7 yr). MS was defined using National Cholesterol Education Programme Adult Treatment Panel III criteria. Resting and exercise stress echocardiography were performed, and myocardial ischemia was identified by new or worsening wall motion abnormalities. Cardiorespiratory fitness was determined using peak oxygen uptake (VO2) by expired gas analysis. Atherosclerotic burden was assessed by carotid intima-media thickness (IMT). Mean peak VO2 was 19 +/- 7 ml/kg per min and was significantly lower than predicted peak VO2 (29 +/- 6 ml/kg per min; P < 0.001). Patients with MS (63%) had reduced CF (17 +/- 6 versus 22 +/- 8 ml/kg per min; P = 0.001) and were more likely to be physically inactive (76 versus 48%; P = 0.02). CF was reduced in 14 patients with myocardial ischemia (15 +/- 3 versus 20 +/- 7 ml/kg per min; P = 0.05). CF was positively correlated with male gender, height, and physical activity and inversely correlated with number of MS risk factors and IMT (adjusted R-2 = 0.66). Carotid IMT added incremental value to clinical variables in determining VO2 (adjusted R-2 = 0.65 versus 0.63; P = 0.04). Reduced CF is associated with physical inactivity, MS, and atherosclerotic burden in glucose-intolerant RTR. Further studies should address whether increasing exercise and modifying MS risk factors improve CF in RTR.
C1 Univ Queensland, Princess Alexandra Hosp, Dept Nephrol, Brisbane, Qld, Australia.
   Univ Queensland, Princess Alexandra Hosp, Dept Endocrinol, Brisbane, Qld, Australia.
   Univ Queensland, Princess Alexandra Hosp, Dept Resp Med, Brisbane, Qld, Australia.
   Univ Queensland, Princess Alexandra Hosp, Sch Med, Brisbane, Qld, Australia.
C3 Princess Alexandra Hospital; University of Queensland; Princess
   Alexandra Hospital; University of Queensland; University of Queensland;
   Princess Alexandra Hospital; Princess Alexandra Hospital; University of
   Queensland
RP Armstrong, K (corresponding author), Princess Alexandra Hosp, Dept Renal Med, Level 2,ARTS Bldg,Ipswich Rd, Brisbane, Qld 4102, Australia.
EM kirsty@ascom.net
RI Marwick, Thomas/AAK-3869-2021; Isbel, Nicole/G-5604-2011; Garske,
   Luke/AAV-4965-2021; Prins, Johannes/I-3610-2019; Prins,
   Johannes/M-5884-2013; Johnson, David/F-2897-2011; Marwick,
   Thomas/C-7261-2013
OI Prins, Johannes/0000-0001-9497-927X; Garske, Luke/0000-0001-5577-5143;
   Johnson, David/0000-0001-5491-3460; Marwick, Thomas/0000-0001-9065-0899
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NR 41
TC 30
Z9 33
U1 0
U2 5
PU AMER SOC NEPHROLOGY
PI WASHINGTON
PA 1725 I ST, NW STE 510, WASHINGTON, DC 20006 USA
SN 1555-9041
EI 1555-905X
J9 CLIN J AM SOC NEPHRO
JI Clin. J. Am. Soc. Nephrol.
PD NOV
PY 2006
VL 1
IS 6
BP 1275
EP 1283
DI 10.2215/CJN.00210106
PG 9
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 107CK
UT WOS:000242148100024
PM 17699359
OA Bronze
DA 2025-06-11
ER

PT J
AU Greeshma, J
   Mini, GK
   Pillai, AM
   Irazola, V
AF Greeshma, J.
   Mini, G. K.
   Pillai, A. Marthanda
   Irazola, Vilma
TI Cardiovascular disease risk factor prevalence among police officials:
   findings from a cross-sectional study in Kerala, India
SO JOURNAL OF OCCUPATIONAL HEALTH
LA English
DT Article
DE cardiovascular diseases; hypertension; police officials; Kerala; India
ID METABOLIC SYNDROME; HEART-DISEASE; SLEEP QUALITY; WORK STRESS;
   HYPERTENSION; OFFICERS; PERSONNEL; BEHAVIOR; OBESITY; HEALTH
AB Objectives Police officials' stressful and physically demanding activities reportedly increase the risk of cardiovascular disease (CVD). This study explored the prevalence of CVD risk factors such as hypertension, diabetes, tobacco use, alcohol consumption, and overweight among police officials in Kerala, India.Methods A cross-sectional study was conducted among 255 police officials in selected police stations in the Thiruvananthapuram district, Kerala. The World Health Organization STEPs questionnaire for noncommunicable disease risk factor surveillance was used to collect information. We collected STEP 1 (demographics, tobacco use, alcohol consumption, physical activity, and diet) and STEP 2 (weight, height, and blood pressure) data. Multivariable analysis was done to identify factors associated with hypertension.Results The mean age of participants was 42 years (range: 30-55 years) and the majority were men (83.5%). Current use of tobacco or alcohol was reported by 22.7% of the participants. The prevalence of overweight was 64.7% and physical inactivity was 35.1%. Self-reported prevalence of diabetes was 7.5% and of hyperlipidemia was 11.4%. Hypertension prevalence was 40.4%. Among hypertensives, 35.9% were aware, 20.4% were treated, and 5.8% had controlled blood pressure. The control rate was 28.6% among treated hypertensives. When controlling for age, diabetes (odds ratio [OR]: 3.57; 95% CI: 1.16-10.90), and overweight (OR: 1.88; 95% CI: 1.06-3.35) participants were more likely to have hypertension compared with their counterparts.Conclusions Police officers have a high prevalence of significant CVD risk factors such as hypertension, physical inactivity, and being overweight. These findings reinforce the need for interventions addressing the above risk factors to prevent CVD in this population.
C1 [Greeshma, J.; Mini, G. K.; Pillai, A. Marthanda] Ananthapuri Hosp & Res Inst, Global Inst Publ Hlth, Thiruvananthapuram, Kerala, India.
   [Mini, G. K.] Saveetha Inst Med & Tech Sci, Saveetha Dent Coll & Hosp, Dept Publ Hlth Dent, Chennai, India.
   [Mini, G. K.] Ctr Environm & Dev, Thiruvananthapuram, Kerala, India.
   [Pillai, A. Marthanda] Ananthapuri Hosp & Res Inst, Dept Neurosurg, Thiruvananthapuram, Kerala, India.
   [Irazola, Vilma] Inst Clin Effectiveness & Hlth Policy, Dept Res Chron Dis, Buenos Aires, Argentina.
C3 Saveetha Institute of Medical & Technical Science; Saveetha Dental
   College & Hospital
RP Mini, GK (corresponding author), Ananthapuri Hosp & Res Inst, Global Inst Publ Hlth, Thiruvananthapuram, Kerala, India.; Mini, GK (corresponding author), Saveetha Inst Med & Tech Sci, Saveetha Dent Coll & Hosp, Dept Publ Hlth Dent, Chennai, India.; Mini, GK (corresponding author), Ctr Environm & Dev, Thiruvananthapuram, Kerala, India.
EM greeshmajk03@gmail.com; gkmini.2014@gmail.com; dramp2014@gmail.com;
   virazola@iecs.org.ar
RI Mini, GK/ACE-7458-2022
FU Bernard Lown Scholar in the Cardiovascular Health Program of the Harvard
   TH Chan School of Public Health, Harvard University, Cambridge,
   Massachusetts; Kerala University of Health Sciences
FX This study was conducted as a part of the Master of Public Health (MPH)
   dissertation work of the first author (J.G) under Kerala University of
   Health Sciences (KUHS) at the Global Institute of Public Health (GIPH),
   Thiruvananthapuram, Kerala, under the guidance of the corresponding
   author (G.K.M.).
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NR 41
TC 1
Z9 1
U1 1
U2 2
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1341-9145
EI 1348-9585
J9 J OCCUP HEALTH
JI J. Occup. Health
PD JUN 24
PY 2024
VL 66
IS 1
AR uiae025
DI 10.1093/joccuh/uiae025
EA JUN 2024
PG 7
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA WD1N7
UT WOS:001252841700001
PM 38713917
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Gonçalves, AC
   Nunes, AR
   Meirinho, S
   Ayuso-Calles, M
   Roca-Couso, R
   Rivas, R
   Falcao, A
   Alves, G
   Silva, LR
   Flores-Félix, JD
AF Goncalves, Ana C.
   Nunes, Ana R.
   Meirinho, Sara
   Ayuso-Calles, Miguel
   Roca-Couso, Rocio
   Rivas, Raul
   Falcao, Amilcar
   Alves, Gilberto
   Silva, Luis R.
   Flores-Felix, Jose David
TI Exploring the Antioxidant, Antidiabetic, and Antimicrobial Capacity of
   Phenolics from Blueberries and Sweet Cherries
SO APPLIED SCIENCES-BASEL
LA English
DT Article
DE phenolic-enriched fractions; antioxidant capacity; antimicrobial
   effects; anti-quorum sensing abilities; blueberry fruits
ID PRUNUS-AVIUM L.; OXIDATIVE STRESS; FRUIT-QUALITY; DOUBLE-BLIND;
   VACCINIUM-CORYMBOSUM; HUMAN ERYTHROCYTES; METABOLIC SYNDROME;
   ALPHA-AMYLASE; ANTHOCYANIN; CULTIVARS
AB Featured ApplicationThis work analyses the biological potential of blueberries and sweet cherries in several dimensions of human health, reinforcing the research on the benefits of consumption of these fruits.(1) Background: Nowadays, special attention has been paid to red and purple fruits, including blueberries and sweet cherries, since they are highly attractive to consumers due to their organoleptic properties, standing out due to their vibrant red and purple colours and sweet flavour, and nutritional value. (2) Methods: The present study evaluated the phenolic profile of phenolic-enriched extracts from blueberries and sweet cherries and explored their antioxidant potential against DPPH, superoxide and nitric oxide radicals, and ferric species, and their potential to inhibit the a-glucosidase enzyme. Furthermore, their antimicrobial activity was also determined by microdilution method against four Gram-positive strains (Enterococcus faecalis ATCC 29212, Bacillus cereus ATCC 11778, Listeria monocytogenes LMG 16779, and Staphylococcus aureus ATCC 25923) and five Gram-negative strains (Salmonella enterica subsp. enterica ATCC 13311 serovar Typhimurium, Klebsiella pneumoniae ATCC 13883, Proteus mirabilis CECT 170, Serratia marcescens CECT 159, and Acinetobacter baumannii LMG 1025). (3) Results: By chromatographic techniques, eight anthocyanins were detected in blueberry coloured fraction and total extract, and five anthocyanins were detected in sweet cherry total extract and coloured fraction, while quercetin aglycone and chlorogenic acids were the dominant non-coloured compounds in blueberries and sweet cherries, respectively. All extracts demonstrated significant antioxidant properties, as well as the ability to inhibit the activity of a-glucosidase enzyme and the development of various microorganisms. (4) Conclusion: The obtained data evidence the promising biological potential of blueberries and sweet cherries, being highly correlated with the presence of phenolic compounds.
C1 [Goncalves, Ana C.; Nunes, Ana R.; Meirinho, Sara; Alves, Gilberto; Silva, Luis R.; Flores-Felix, Jose David] Univ Beira Interior, Hlth Sci Res Ctr, CICS, P-6201506 Covilha, Portugal.
   [Goncalves, Ana C.; Falcao, Amilcar] Univ Coimbra, CIBIT Coimbra Inst Biomed Imaging & Translat Res, P-3000548 Coimbra, Portugal.
   [Nunes, Ana R.] Univ Coimbra, Fac Med, CNC Ctr Neurosci & Cell Biol, P-3004504 Coimbra, Portugal.
   [Meirinho, Sara] Univ Beira Interior, Fac Hlth Sci, Ave Infante D Henrique, P-6200506 Covilha, Portugal.
   [Ayuso-Calles, Miguel; Roca-Couso, Rocio; Rivas, Raul] Univ Salamanca, Dept Microbiol & Genet, Salamanca 37007, Spain.
   [Ayuso-Calles, Miguel; Roca-Couso, Rocio; Rivas, Raul] Inst Agribiotechnol Res CIALE, Salamanca 37185, Spain.
   [Rivas, Raul] Univ Salamanca, Associated Res Unit Plant Microorganism Interact, IRNASA, CSIC, Salamanca 37008, Spain.
   [Falcao, Amilcar] Univ Coimbra, Fac Pharm, Lab Pharmacol, P-3000548 Coimbra, Portugal.
   [Silva, Luis R.] Inst Politecn Guarda, Ctr Potencial & Inovacao Recursos Nat, Unidade Invest Desenvolvimento Interior, UDI, P-6300559 Guarda, Portugal.
   [Silva, Luis R.] Univ Coimbra, Dept Chem Engn, CIEPQPF, Polo 2 Pinhal de Marrocos, P-3030790 Coimbra, Portugal.
C3 Universidade da Beira Interior; Universidade de Coimbra; Universidade de
   Coimbra; Universidade da Beira Interior; University of Salamanca;
   Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Instituto
   de Recursos Naturales y Agrobiologia de Salamanca (IRNASA); University
   of Salamanca; Universidade de Coimbra; Instituto Politecnico da Guarda;
   Universidade de Coimbra
RP Flores-Félix, JD (corresponding author), Univ Beira Interior, Hlth Sci Res Ctr, CICS, P-6201506 Covilha, Portugal.
EM anacarolinagoncalves@sapo.pt; araqueln@gmail.com; sara.meirinho@ubi.pt;
   miguelac96@usal.es; rocioroca@usal.es; raulrg@usal.es;
   acfalcao@ff.uc.pt; gilberto@fcsaude.ubi.pt; luisfarmacognosia@gmail.com;
   jdflores@usal.es
RI Falcão, Amílcar/HHY-7322-2022; Ayuso-Calles, Miguel/ABD-8812-2020;
   Rivas, Raúl/B-1869-2017; Meirinho, Sara/KPA-8462-2024; Falcao,
   Amilcar/G-6611-2013; Silva, Luis Rodrigues da/D-5485-2013; Flores Felix,
   Jose David/B-2082-2017; Almeida Goncalves, Ana Carolina/AAX-2647-2021
OI Nunes, Ana Raquel/0000-0001-6847-5764; Roca Couso,
   Rocio/0000-0001-8115-0526; Meirinho, Sara/0000-0001-7978-057X;
   AYUSO-CALLES, MIGUEL/0000-0003-1878-3819; Falcao,
   Amilcar/0000-0002-3854-6549; Rivas, Raul/0000-0003-2202-1470; Silva,
   Luis Rodrigues da/0000-0001-5264-3516; Flores Felix, Jose
   David/0000-0003-2200-4400; Almeida Goncalves, Ana
   Carolina/0000-0001-7795-795X
FU European Union [101003373]; European Union NextGenerationEU; Portuguese
   Government [PRR-C05-i03-I-000143]; Foundation for Science and Technology
   (FCT); Ministry of Science, Technology and Higher Education (MCTES);
   European Social Fund (EFS); European Union (EU) [2020.04947.BD,
   SFRH/BD/139137/2018]
FX The authors are grateful to the Foundation for Science and Technology
   (FCT), the Ministry of Science, Technology and Higher Education (MCTES),
   the European Social Fund (EFS), and the European Union (EU) for the
   Ph.D. fellowships of Ana C. Goncalves (2020.04947.BD) and Ana R. Nunes
   (SFRH/BD/139137/2018). Jose D. Flores-Felix was supported by the
   European Union's Horizon 2020 research and innovation programme under
   the Marie Sklodowska-Curie grant agreement no. 101003373, and the
   European Union NextGenerationEU and the Portuguese Government under the
   project PRR-C05-i03-I-000143 (RedFruit4Health).
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NR 91
TC 10
Z9 10
U1 5
U2 23
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3417
J9 APPL SCI-BASEL
JI Appl. Sci.-Basel
PD MAY 22
PY 2023
VL 13
IS 10
AR 6348
DI 10.3390/app13106348
PG 18
WC Chemistry, Multidisciplinary; Engineering, Multidisciplinary; Materials
   Science, Multidisciplinary; Physics, Applied
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Engineering; Materials Science; Physics
GA H4GD2
UT WOS:000995556400001
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Lu, LW
   Gao, Y
   Quek, SY
   Foster, M
   Eason, CT
   Liu, M
   Wang, MF
   Chen, JH
   Chen, F
AF Lu, Louise W.
   Gao, Yao
   Quek, Siew-Young
   Foster, Meika
   Eason, Charles T.
   Liu, Min
   Wang, Mingfu
   Chen, Jie-Hua
   Chen, Feng
TI The landscape of potential health benefits of carotenoids as natural
   supportive therapeutics in protecting against Coronavirus infection
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Review
DE Carotenoids; COVID-19; SARS-CoV-2; Anti -inflammation; Immunity; Natural
   supportive therapeutics
ID INFLAMMATORY GENE-EXPRESSION; CARDIOVASCULAR-DISEASE RISK; ACTIVATED
   RECEPTOR-GAMMA; INDUCED OXIDATIVE STRESS; WHITE ADIPOSE-TISSUE; 3RD
   NATIONAL-HEALTH; ACUTE LUNG INJURY; BETA-CAROTENE; METABOLIC SYNDROME;
   LIPID-PEROXIDATION
AB The Coronavirus Disease-2019 (COVID-19) pandemic urges researching possibilities for prevention and man-agement of the effects of the virus. Carotenoids are natural phytochemicals of anti-oxidant, anti-inflammatory and immunomodulatory properties and may exert potential in aiding in combatting the pandemic. This review presents the direct and indirect evidence of the health benefits of carotenoids and derivatives based on in vitro and in vivo studies, human clinical trials and epidemiological studies and proposes possible mechanisms of action via which carotenoids may have the capacity to protect against COVID-19 effects. The current evidence provides a rationale for considering carotenoids as natural supportive nutrients via antioxidant activities, including scavenging lipid-soluble radicals, reducing hypoxia-associated superoxide by activating antioxidant enzymes, or suppressing enzymes that produce reactive oxygen species (ROS). Carotenoids may regulate COVID-19 induced over-production of pro-inflammatory cytokines, chemokines, pro-inflammatory enzymes and adhe-sion molecules by nuclear factor kappa B (NF-kappa B), renin-angiotensin-aldosterone system (RAS) and interleukins- 6-Janus kinase-signal transducer and activator of transcription (IL-6-JAK/STAT) pathways and suppress the polarization of pro-inflammatory M1 macrophage. Moreover, carotenoids may modulate the peroxisome proliferator-activated receptors gamma by acting as agonists to alleviate COVID-19 symptoms. They also may poten-tially block the cellular receptor of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), human angiotensin-converting enzyme 2 (ACE2). These activities may reduce the severity of COVID-19 and flu-like diseases. Thus, carotenoid supplementation may aid in combatting the pandemic, as well as seasonal flu. However, further in vitro, in vivo and in particular long-term clinical trials in COVID-19 patients are needed to evaluate this hypothesis.
C1 [Lu, Louise W.] Univ Auckland, Sch Biol Sci, Dept Med, Auckland, New Zealand.
   [Gao, Yao] Univ Macau, Fac Hlth Sci, Macau, Macao, Peoples R China.
   [Quek, Siew-Young] Univ Auckland, Sch Chem Sci, Food Sci, Auckland, New Zealand.
   [Quek, Siew-Young] New Zealand Ctr Res Excellence Food Res, Riddet Inst, Palmerston North, New Zealand.
   [Foster, Meika] Edible Res Ltd, Auckland, New Zealand.
   [Foster, Meika; Eason, Charles T.] Wakatu Inc, Nelson, New Zealand.
   [Eason, Charles T.] Lincoln Univ, Lincoln, New Zealand.
   [Liu, Min] Southern Med Univ, Sch Publ Hlth, Dept Pathogen Biol, Guangdong Prov Key Lab Trop Dis Res, Guangzhou 510515, Guangdong, Peoples R China.
   [Wang, Mingfu; Chen, Jie-Hua; Chen, Feng] Shenzhen Univ, Inst Innovat Dev Food Ind, Shenzhen, Peoples R China.
   [Wang, Mingfu; Chen, Jie-Hua; Chen, Feng] Shenzhen Univ, Inst Adv Study, Shenzhen Key Lab Marine Microbiome Engn, Shenzhen, Peoples R China.
   [Chen, Jie-Hua; Chen, Feng] Shenzhen Univ, 3688 Nanhai Ave, Shenzhen 518060, Guangdong, Peoples R China.
C3 University of Auckland; University of Macau; University of Auckland;
   Southern Medical University - China; Shenzhen University; Shenzhen
   University; Shenzhen University
RP Chen, JH; Chen, F (corresponding author), Shenzhen Univ, 3688 Nanhai Ave, Shenzhen 518060, Guangdong, Peoples R China.
EM siyanpijiehua@gmail.com; sfchen@szu.edu.cn
RI Wang, Mingfu/AAT-3292-2021; chen, jiehua/NAZ-5029-2025; Chen,
   Feng/B-1079-2012
FU National Natural Science Foundation of China [31601472]; Guangdong
   Province Zhujiang Talent Program [2019ZT08H476]; Shenzhen Science and
   Technology Program [KQTD20180412181334790]
FX Funding This work was supported by the National Natural Science
   Foundation of China (grant number 31601472) ; Guangdong Province
   Zhujiang Talent Program (grant number 2019ZT08H476) ; and Shenzhen
   Science and Technology Program (grant number KQTD20180412181334790) .
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NR 297
TC 6
Z9 6
U1 1
U2 14
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD OCT
PY 2022
VL 154
AR 113625
DI 10.1016/j.biopha.2022.113625
EA SEP 2022
PG 21
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA 4X1YI
UT WOS:000860644900005
PM 36058151
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Correa-Rodríguez, M
   Gómez-Urquiza, JL
   Medina-Martínez, I
   González-Jiménez, E
   Schmidt-RioValle, J
   Rueda-Medina, B
AF Correa-Rodriguez, Maria
   Luis Gomez-Urquiza, Jose
   Medina-Martinez, Irene
   Gonzalez-Jimenez, Emilio
   Schmidt-RioValle, Jaqueline
   Rueda-Medina, Blanca
TI Low intakes of vitamins C and A are associated with obesity in early
   adulthood
SO INTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCH
LA English
DT Article
DE vitamin A; vitamin C; antioxidants; obesity; dietary intake
ID DIETARY MAGNESIUM INTAKE; BODY-MASS INDEX; SERUM CONCENTRATIONS; WAIST
   CIRCUMFERENCE; METABOLIC SYNDROME; ANTIOXIDANT INTAKE; OXIDATIVE STRESS;
   ALPHA-TOCOPHEROL; BETA-CAROTENE; WEIGHT
AB To evaluate the relationships between the intake of individual antioxidants as well as the dietary antioxidant quality score and obesity-related measures. A cross-sectional study was conducted on 562 young adults. Fat mass, fat-mass percentage, and fat-free mass were measured using a body composition analyzer. The intake of antioxidant nutrients including vitamins C, E, and A, selenium, zinc, and magnesium were calculated based on a 72-hour diet recall interview. We observed significant differences in the vitamin C (88.6 +/- 72.6 mg/day vs. 70.7 +/- 60.6 mg/day, p = 0.010), vitamin A (635.8 +/- 519.8 mu g/day vs. 492.6 +/- 318.9 mu g/day, p = 0.014), and selenium (135.3 +/- 88.7 mu g/day vs. 139.3 +/- 79.3 mu g/day, p = 0.034) intake between normal-weight and overweight or obese young adults. When the Dietary Antioxidant Quality Score (DAQS) was analyzed, there were no significant differences between normal-weight versus overweight or obese young adults after adjusting for confounders. Logistic regression analysis revealed that vitamin C intake (odds ratio (OR) 0.995, 95% CI 0.992-0.999, p = 0.013) and vitamin A intake (OR 0.999, 95% CI 0.999-1.000, p = 0.016) were independent predictors of overweight/obesity after adjusting for age, sex and energy intake. In contrast, a higher selenium intake was associated with an increased risk of overweight/obesity (OR 1.003, 95% CI 1.000-1.006, p = 0.034). Future longitudinal investigations of dietary antioxidant intake in relation to the development of obesity would be of interest to better understand the effect of dietary antioxidants on obesity.
C1 [Correa-Rodriguez, Maria; Luis Gomez-Urquiza, Jose; Medina-Martinez, Irene; Gonzalez-Jimenez, Emilio; Schmidt-RioValle, Jaqueline; Rueda-Medina, Blanca] Univ Granada, Nursing Dept, Fac Hlth Sci, Granada, Spain.
C3 University of Granada
RP Correa-Rodríguez, M (corresponding author), Univ Granada, Fac Hlth Sci, Av Ilustrac S-N, Granada 18018, Spain.
EM macoro@ugr.es
RI Urquiza, Jose/K-9421-2017; González-Jiménez, Emilio/I-6039-2017;
   Correa-Rodriguez, Maria/G-1793-2018; Rueda-Medina, Blanca/F-3156-2019
OI Correa-Rodriguez, Maria/0000-0001-9165-4349; Rueda-Medina,
   Blanca/0000-0002-0263-7000
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NR 52
TC 11
Z9 11
U1 1
U2 12
PU IMR PRESS
PI ROBINSON
PA 112 ROBINSON RD, ROBINSON, SINGAPORE
SN 0300-9831
EI 1664-2821
J9 INT J VITAM NUTR RES
JI Int. J. Vitam. Nutr. Res.
PD JUL
PY 2022
VL 92
IS 3-4
BP 204
EP 213
DI 10.1024/0300-9831/a000661
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 3B4WV
UT WOS:000827944100006
PM 32646290
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Yousefzadeh, N
   Jeddi, S
   Shokri, M
   Afzali, H
   Norouzirad, R
   Kashfi, K
   Ghasemi, A
AF Yousefzadeh, Nasibeh
   Jeddi, Sajad
   Shokri, Majid
   Afzali, Hamideh
   Norouzirad, Reza
   Kashfi, Khosrow
   Ghasemi, Asghar
TI Long Term Sodium Nitrate Administration Positively Impacts Metabolic and
   Obesity Indices in Ovariectomized Rats
SO ARCHIVES OF MEDICAL RESEARCH
LA English
DT Article
DE Nitrate; Obesity indices; Lipid metabolism; Carbohydrate metabolism;
   Ovariectomy; Gonadal adipose tissue; Rat
ID WHITE ADIPOSE-TISSUE; OXIDE NITRITE/NITRATE LEVELS;
   ESTROGEN-RECEPTOR-ALPHA; NITRIC-OXIDE; INSULIN SENSITIVITY; INORGANIC
   NITRATE; DIETARY NITRATE; BLOOD-PRESSURE; OXIDATIVE STRESS;
   SKELETAL-MUSCLE
AB Background. In postmenopausal women, nitric oxide (NO) deficiency is associated with obesity and type 2 diabetes (T2D). This study aims at determining the long-term effects of low-dose nitrate administration on metabolic and obesity indices in ovariectomized (OVX) rats. Methods. OVX rat model was induced using the two dorsolateral skin incision method. Two months after ovariectomy, rats were divided into three groups (eta = 10/group): Control, OVX, and OVX + nitrate, and the latter received sodium nitrate at a dose of 100 mg/L in their drinking water for nine months. Fasting serum glucose and lipid profile were measured every month. A glucose tolerance test was performed at months 1, 3, and 9 (the end of the study). Obesity indices were calculated, and histological analyses were performed on the gonadal adipose tissues at month 9. Results. OVX rats had impaired fasting glucose, glucose intolerance, and dyslipidemia with higher obesity indices at month 9. Nitrate improved glucose and lipid metabolism in OVX rats and decreased body weight (6.9%), body mass index (12.5%), Lee index (5.4%), adiposity index (23.9%), abdominal circumference (10.5%), and thoracic circumference (17.1%). Also, nitrate decreased adipocyte area by 49% and increased adipocyte density by 193% in gonadal adipose tissue. Conclusion. Long-term low-dose nitrate administration improves glucose and lipid metabolism in OVX rats in association with decreasing OVX-induced adiposity, increasing adipocyte density, and decreasing adipocyte area. These findings provide support for a potential therapeutic role of nitrate in postmenopausal women with some features of metabolic syndrome.(c) 2021 Instituto Mexicano del Seguro Social (IMSS). Published by Elsevier Inc. All rights reserved.
C1 [Yousefzadeh, Nasibeh; Jeddi, Sajad; Shokri, Majid; Afzali, Hamideh; Ghasemi, Asghar] Shahid Beheshti Univ Med Sci, Res Inst Endocrine Sci, Endocrine Physiol Res Ctr, 24,Arabi St,Daneshjoo Blvd,Velenjak,POB 19395-476, Tehran, Iran.
   [Norouzirad, Reza] Dezful Univ Med Sci, Sch Allied Med Sci, Dezful, Iran.
   [Kashfi, Khosrow] CUNY, Sch Med, Sophie Davis Sch Biomed Educ, Dept Mol Cellular & Biomed Sci, New York, NY USA.
C3 Shahid Beheshti University Medical Sciences; City University of New York
   (CUNY) System; Sophie Davis School of Biomedical Education
RP Ghasemi, A (corresponding author), Shahid Beheshti Univ Med Sci, Res Inst Endocrine Sci, Endocrine Physiol Res Ctr, 24,Arabi St,Daneshjoo Blvd,Velenjak,POB 19395-476, Tehran, Iran.
EM Ghasemi@endocrine.ac.ir
RI Jeddi, Sajad/U-8493-2019; Afzali, Hamideh/ISB-3275-2023; Ghasemi,
   Asghar/O-4145-2017; Norouzirad, Reza/L-7475-2015; Kashfi,
   Khosrow/A-4351-2008
OI Jeddi, Sajad/0000-0002-3911-6620; Ghasemi, Asghar/0000-0001-6867-2151;
   Norouzirad, Reza/0000-0002-5046-057X; Kashfi,
   Khosrow/0000-0002-4060-7283
FU Shahid Beheshti University of Medical Sciences [26758-5]; Tehran, Iran
FX This study was supported by Shahid Beheshti University of Medical
   Sciences (grant No. 26758-5) , Tehran, Iran.
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NR 77
TC 5
Z9 5
U1 2
U2 9
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0188-4409
EI 1873-5487
J9 ARCH MED RES
JI Arch. Med. Res.
PD FEB
PY 2022
VL 53
IS 2
BP 147
EP 156
DI 10.1016/j.arcmed.2021.09.007
PG 10
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 0Y2IQ
UT WOS:000790218100005
PM 34696904
DA 2025-06-11
ER

PT J
AU Pallesen, S
   Jacobsen, DP
   Nielsen, MB
   Gjerstad, J
AF Pallesen, Stale
   Jacobsen, Daniel Pitz
   Nielsen, Morten B.
   Gjerstad, Johannes
TI The 5-HTTLPR rs25531 LALA-genotype increases the
   risk of insomnia symptoms among shift workers
SO SLEEP MEDICINE
LA English
DT Article
DE Chronobiology; Genetics; Insomnia symptoms; Shift work; Shift work
   tolerance
ID BREAST-CANCER RISK; METABOLIC SYNDROME; CIRCADIAN-RHYTHM; NIGHT WORK;
   HPA AXIS; SEROTONIN; POLYMORPHISM; SLEEP; STRESS; ASSOCIATION
AB Background: Previous studies indicate that shift work tolerance may be associated with individual factors including genetic variability in the gene encoding the serotonin transporter 5-HTT (SLC6A4). The present study aimed to explore the interaction between work schedule (shift work versus non-shift work), genetic variability in SLC6A4 and insomnia symptoms.
   Methods: The study was based on a national probability sample survey of 987 Norwegian employees drawn from The Norwegian Central Employee Register by Statistics Norway. Insomnia symptoms were assessed by three items reflecting problems with sleep onset, sleep maintenance, and early morning awakenings. Genotyping concerning SLC6A4 (the 5-HTTLPR S versus L and the SNP rs25531 A versus G) was carried out using a combination of gel-electrophoresis and TaqMan assay.
   Results: Using the LALA genotype as a reference a main effect of the SS genotype (B = 0.179; 95% CI = 0.027-0.330) was found. In addition, a main effect of work schedule (0 = non shift, 1 = shift work) was found (B = 0.504; 95% CI = 0.185-0.823). The genotype x work schedule interaction was significant for all genotypes; SLA (B = -0.590; 95% CI = -0.954-0.216), LALG (B = -0.879; 95% CI = -1.342-0.415), SLG (B = -0.705; 95% CI = -1.293-0.117) and SS (B = -0.773; 95% CI = -1.177-0.369) indicating higher insomnia symptom scores among LALA-participants compared to participants with other genotypes when working shifts.
   Conclusions: The ability to cope with shift work is associated with the combination of the SLC6A4 variants 5-HTTLPR and SNP rs25531. Our findings demonstrated that the LALA-genotype increases the risk of insomnia symptoms among shift workers. (C) 2019 Elsevier B.V. All rights reserved.
C1 [Pallesen, Stale; Nielsen, Morten B.] Univ Bergen, Dept Psychosocial Sci, Post Box 7807, N-5020 Bergen, Norway.
   [Pallesen, Stale] Haukeland Hosp, Norwegian Competence Ctr Sleep Disorders, Bergen, Norway.
   [Jacobsen, Daniel Pitz; Nielsen, Morten B.; Gjerstad, Johannes] Natl Inst Occupat Hlth, Oslo, Norway.
C3 University of Bergen; University of Bergen; Haukeland University
   Hospital
RP Pallesen, S (corresponding author), Univ Bergen, Dept Psychosocial Sci, Post Box 7807, N-5020 Bergen, Norway.
EM pklsp@uib.no
OI Nielsen, Morten Birkeland/0000-0001-7858-8623; Pallesen,
   Stale/0000-0002-5831-0840; Jacobsen, Daniel Pitz/0000-0003-3229-6830
FU Norwegian Research Council [237777]
FX This work was supported by the Norwegian Research Council (grant no.
   237777).
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NR 68
TC 9
Z9 10
U1 0
U2 6
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1389-9457
EI 1878-5506
J9 SLEEP MED
JI Sleep Med.
PD AUG
PY 2019
VL 60
BP 224
EP 229
DI 10.1016/j.sleep.2019.04.009
PG 6
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology
GA IG3PX
UT WOS:000473718100032
PM 31213395
OA Green Published, Green Accepted
DA 2025-06-11
ER

PT J
AU Chaudhary, P
   Schreihofer, AM
AF Chaudhary, Parul
   Schreihofer, Ann M.
TI Improved glucose homeostasis in male obese Zucker rats coincides with
   enhanced baroreflexes and activation of the nucleus tractus solitarius
SO AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE
   PHYSIOLOGY
LA English
DT Article
DE baroreceptor reflex; hyperglycemia; metabolic syndrome; metformin;
   pioglitazone
ID BLOOD-PRESSURE VARIABILITY; ROSTRAL VENTROLATERAL MEDULLA;
   SYMPATHETIC-NERVE ACTIVITY; HEART-RATE; BARORECEPTOR REFLEX;
   MICROVASCULAR RAREFACTION; INDUCED HYPERTENSION; POSSIBLE INVOLVEMENT;
   INSULIN SENSITIVITY; ARTERIAL BAROREFLEX
AB Young adult male obese Zucker rats (OZR) develop insulin resistance and hypertension with impaired baroreflex-mediated bradycardia and activation of nucleus tractus solitarius (NTS). Because type 1 diabetic rats also develop impaired baroreflex-mediated NTS activation, we hypothesized that improving glycemic control in OZR would enhance compromised baroreflexes and NTS activation. Fasting blood glucose measured by telemetry was comparable in OZR and lean Zucker rats (LZR) at 12-17 wk. However, with access to food, OZR were chronically hyperglycemic throughout this age range. By 15-17 wk of age, tail samples yielded higher glucose values than those measured by telemetry in OZR but not LZR, consistent with reports of exaggerated stress responses in OZR. Injection of glucose (1g/kg ip) produced larger rises in glucose and areas under the curve in OZR than LZR. Treatment with metformin (300 mg.kg(-1).day(-1)) or pioglitazone (5 mg.kg(-1).day(-1)) in drinking water for 2-3 wk normalized fed glucose levels in OZR with no effect in LZR. After metformin treatment, area under the curve for blood glucose after glucose injection was reduced in OZR and comparable to LZR. Hyperinsulinemia was slightly reduced by each treatment in OZR, but insulin was still greatly elevated compared with LZR. Neither treatment reduced hypertension in OZR, but both treatments significantly improved the blunted phenylephrine-induced bradycardia and NTS c-Fos expression in OZR with no effect in LZR. These data suggest that restoring glycemic control in OZR enhances baroreflex control of heart rate by improving the response of the NTS to raising arterial pressure, even in the presence of hyperinsulinemia and hypertension.
C1 [Chaudhary, Parul; Schreihofer, Ann M.] Univ North Texas, Hlth Sci Ctr, Dept Physiol & Anat, 3500 Camp Bowie Blvd, Ft Worth, TX 76107 USA.
C3 University of North Texas System; University of North Texas Health
   Science Center; University of North Texas Denton
RP Schreihofer, AM (corresponding author), Univ North Texas, Hlth Sci Ctr, Dept Physiol & Anat, 3500 Camp Bowie Blvd, Ft Worth, TX 76107 USA.
EM Ann.Schreihofer@unthsc.edu
OI Chaudhary, Parul/0000-0002-5181-6515; Schreihofer,
   Ann/0000-0003-0069-2847
FU National Heart, Lung, and Blood Institute [R01-HL-132568]; Institute for
   Cardiovascular and Metabolic Disease at UNTHSC; American Heart
   Association [PRE27260088]
FX This project was financially supported by National Heart, Lung, and
   Blood Institute Grant R01-HL-132568 and a Seed Grant from the Institute
   for Cardiovascular and Metabolic Disease at UNTHSC to A. M. Schreihofer.
   In addition, P. Chaudhary was supported by predoctoral fellowship
   PRE27260088 from the American Heart Association.
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NR 94
TC 10
Z9 11
U1 0
U2 3
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0363-6119
EI 1522-1490
J9 AM J PHYSIOL-REG I
JI Am. J. Physiol.-Regul. Integr. Comp. Physiol.
PD DEC
PY 2018
VL 315
IS 6
BP R1195
EP R1209
DI 10.1152/ajpregu.00195.2018
PG 15
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA HI2WC
UT WOS:000456306100012
PM 30256679
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Akash, MSH
   Rehman, K
   Liaqat, A
   Numan, M
   Mahmood, Q
   Kamal, S
AF Akash, Muhammad Sajid Hamid
   Rehman, Kanwal
   Liaqat, Aamira
   Numan, Muhammad
   Mahmood, Qaisar
   Kamal, Shagufta
TI Biochemical investigation of gender-specific association between insulin
   resistance and inflammatory biomarkers in types 2 diabetic patients
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Article
DE Diabetes mellitus; Insulin resistance; Inflammatory biomarkers;
   Gender-specific association
ID NECROSIS-FACTOR-ALPHA; INTERLEUKIN-1 RECEPTOR ANTAGONIST; IMPAIRED
   GLUCOSE-TOLERANCE; METABOLIC SYNDROME; OXIDATIVE STRESS; TNF-ALPHA;
   MELLITUS; PATHOGENESIS; SENSITIVITY; MECHANISMS
AB Inflammatory mediators play a key role in the pathogenesis of type 2 diabetes mellitus (T2DM) and development of insulin resistance (IR). The purpose of the present study was to investigate the gender-specific association between serum levels of inflammatory biomarkers and development of IR in type 2 diabetic patients. We recruited 90 study participants and collected their blood samples to measure the serum level of interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), C-reactive protein (CRP), insulin and glucose. We found that the serum levels of IL-6 (< 0.0001), TNF-alpha ( < 0.0001) and CRP (< 0.0001) in type 2 diabetic patients were significantly high as compared to control participants. Moreover, we also found that in female diabetic patients, a significant association was observed between the elevated levels of IL-6 (r = 0.8819, R-2 = 0.7778), TNF-alpha (r = 0.9833, R-2 = 0.9669) and CRP (r = 0.9529, R-2 = 0.9080) and increased risk of developing IR when compared with that of the serum levels of IL-6 (r = 0.7977, R-2 = 0.6364), TNF-alpha (r = 0.9445, R-2 = 0.8920) and CRP (r = 0.9051, R-2 = 0.8192) of male diabetic patients. Additionally, we also found that the Body mass index (BMI) of female diabetic patients was strongly correlated (r = 0.9694, R-2 = 0.9398) with the increased incidence of IR as compared to that of the BMI (r = 0.9188, R-2 = 0.8442) of male diabetic patients. The key findings of present study exhibit that gender differences significantly influence the association of inflammatory biomarkers with the development of IR in T2DM.
C1 [Akash, Muhammad Sajid Hamid; Liaqat, Aamira; Numan, Muhammad] Govt Coll Univ, Dept Pharmaceut Chem, Faisalabad, Pakistan.
   [Rehman, Kanwal] Univ Agr Faisalabad, Inst Pharm Physiol & Pharmacol, Faisalabad, Pakistan.
   [Liaqat, Aamira; Kamal, Shagufta] Govt Coll Univ, Dept Biochem, Faisalabad, Pakistan.
   [Mahmood, Qaisar] Univ Sargodha, Coll Pharm, Sargodha, Pakistan.
C3 Government College University Faisalabad; University of Agriculture
   Faisalabad; Government College University Faisalabad; University of
   Sargodha
RP Akash, MSH (corresponding author), Govt Coll Univ, Dept Pharmaceut Chem, Faisalabad, Pakistan.; Rehman, K (corresponding author), Univ Agr Faisalabad, Inst Pharm Physiol & Pharmacol, Faisalabad, Pakistan.
EM sajidakash@gcuf.edu.pk; kanwal.akash@uaf.edu.pk
RI Mahmood, Qaisar/AFH-0876-2022; kamal, shagufta/NJR-5815-2025; Rehman,
   Kanwal/P-7727-2014; Akash, Muhammad Sajid Hamid/C-3477-2018
OI kamal, shagufta/0000-0003-4002-0359; Numan,
   Muhammad/0000-0003-0987-660X; Rehman, Kanwal/0000-0001-7873-6681; kamal,
   shagufta/0000-0003-4073-2583; Akash, Muhammad Sajid
   Hamid/0000-0002-9446-5233
FU Higher Education Commission (HEC) of Pakistan [21-1061/SRGP/RD/
   HEC/2016]
FX We would like to acknowledge the Higher Education Commission (HEC) of
   Pakistan to financially support this research work (Project#
   21-1061/SRGP/R&D/ HEC/2016).
CR Akash MSH, 2018, J CELL BIOCHEM, V119, P105, DOI 10.1002/jcb.26174
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NR 30
TC 19
Z9 21
U1 0
U2 7
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD OCT
PY 2018
VL 106
BP 285
EP 291
DI 10.1016/j.biopha.2018.06.044
PG 7
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA GR4QO
UT WOS:000442600300036
PM 29966972
DA 2025-06-11
ER

PT J
AU Shen, Y
   Ding, FH
   Dai, Y
   Wang, XQ
   Zhang, RY
   Lu, L
   Shen, WF
AF Shen, Ying
   Ding, Feng Hua
   Dai, Yang
   Wang, Xiao Qun
   Zhang, Rui Yan
   Lu, Lin
   Shen, Wei Feng
TI Reduced coronary collateralization in type 2 diabetic patients with
   chronic total occlusion
SO CARDIOVASCULAR DIABETOLOGY
LA English
DT Review
DE Coronary artery disease; Type 2 diabetes mellitus; Coronary collateral
   circulation; Chronic total occlusion
ID ENDOTHELIAL GROWTH-FACTOR; GLYCATION END-PRODUCTS; ARTERY-DISEASE;
   CARDIOVASCULAR-DISEASE; VESSEL DEVELOPMENT; BLOOD-PRESSURE; CYSTATIN C;
   THERAPEUTIC IMPLICATIONS; STENT IMPLANTATION; METABOLIC SYNDROME
AB Background: The extent of coronary collateral formation is a primary determinant of the severity of myocardial damage and mortality after coronary artery occlusion. Type 2 diabetes mellitus (T2DM) represents an important risk factor for impaired collateral vessel growth. However, the mechanism of reduced coronary collateralization in type 2 diabetic patients remains unclear.
   Methods: With the reference to the recent researches, this review article describes the pathogenic effects of T2DM on collateral development and outlines possible clinical and biochemical markers associated with reduced coronary collateralization in type 2 diabetic patients with chronic total occlusion (CTO).
   Results: Diffuse coronary atherosclerosis in T2DM reduces pressure gradient between collateral donor artery and collateral recipient one, limiting collateral vessel growth and function. An interaction between advanced glycation end-products and their receptor activates several intracellular signaling pathways, enhances oxidative stress and aggravates inflammatory process. Diabetic condition decreases pro-angiogenic factors especially vascular endothelial growth factor and other collateral vessel growth related parameters. Numerous clinical and biochemical factors that could possibly attenuate the development of coronary collaterals have been reported. Increased serum levels of glycated albumin, cystatin C, and adipokine C1q tumor necrosis factor related protein 1 were associated with poor coronary collateralization in type 2 diabetic patients with stable coronary artery disease and CTO. Diastolic blood pressure and stenosis severity of the predominant collateral donor artery also play a role in coronary collateral formation.
   Conclusions: T2DM impairs collateral vessel growth through multiple mechanisms involving arteriogenesis and angiogenesis, and coronary collateral formation in patients with T2DM and CTO is influenced by various clinical, biochemical and angiographic factors. This information provides insights into the understanding of coronary pathophysiology and searching for potential new therapeutic targets in T2DM.
C1 [Shen, Ying; Ding, Feng Hua; Wang, Xiao Qun; Zhang, Rui Yan; Lu, Lin; Shen, Wei Feng] Shanghai Jiao Tong Univ, Sch Med, Rui Jin Hosp, Dept Cardiol, Shanghai 200025, Peoples R China.
   [Dai, Yang; Lu, Lin; Shen, Wei Feng] Shanghai Jiao Tong Univ, Sch Med, Inst Cardiovasc Dis, 197 Rui Jin Rd 2, Shanghai 200025, Peoples R China.
C3 Shanghai Jiao Tong University; Shanghai Jiao Tong University
RP Shen, WF (corresponding author), Shanghai Jiao Tong Univ, Sch Med, Inst Cardiovasc Dis, 197 Rui Jin Rd 2, Shanghai 200025, Peoples R China.
EM rjshenweifeng@126.com
RI Shen, Weifeng/AAE-2493-2022; Zhang, Ruiyan/HHC-5329-2022
OI Wang, Xiao Qun/0000-0003-0956-8041
FU Research Foundation of Chinese National Natural Science [81400327];
   Shanghai Science & Technology Committee [14ZR1425800];
   Medico-engineering Project Shanghai Jiao Tong University School of
   Medicine [GY2016MS66]; Talent Young Investigators of Shanghai Jiao Tong
   University School of Medicine [17XJ11009]
FX This study was supported in part by the Research Foundation of Chinese
   National Natural Science (81400327), Shanghai Science & Technology
   Committee (14ZR1425800) and Medico-engineering Project (GY2016MS66) and
   Talent Young Investigators (17XJ11009) of Shanghai Jiao Tong University
   School of Medicine.
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NR 94
TC 63
Z9 67
U1 1
U2 20
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1475-2840
J9 CARDIOVASC DIABETOL
JI Cardiovasc. Diabetol.
PD FEB 8
PY 2018
VL 17
AR 26
DI 10.1186/s12933-018-0671-6
PG 9
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism
GA FW2CV
UT WOS:000425110500001
PM 29422093
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Pastor-Villaescusa, B
   Canete, MD
   Caballero-Villarraso, J
   Hoyos, R
   Latorre, M
   Vázquez-Cobela, R
   Plaza-Diaz, J
   Maldonado, J
   Bueno, G
   Leis, R
   Gil, A
   Cañete, R
   Aguilera, CM
AF Pastor-Villaescusa, Belen
   Canete, M. Dolores
   Caballero-Villarraso, Javier
   Hoyos, Rayal
   Latorre, Miriam
   Vazquez-Cobela, Rocio
   Plaza-Diaz, Julio
   Maldonado, Jose
   Bueno, Gloria
   Leis, Rosaura
   Gil, Angel
   Canete, Ramon
   Aguilera, Concepcion M.
TI Metformin for Obesity in Prepubertal and Pubertal Children: A Randomized
   Controlled Trial
SO PEDIATRICS
LA English
DT Article
ID INSULIN-RESISTANT ADOLESCENTS; METABOLIC SYNDROME; ENDOTHELIAL FUNCTION;
   GLUCOSE-TOLERANCE; OXIDATIVE STRESS; TERM TREATMENT; HYPERINSULINEMIA;
   OVERWEIGHT; MARKERS; WEIGHT
AB OBJECTIVES: Metformin has shown its effectiveness in treating obesity in adults. However, little research has been conducted in children, with a lack of attention on pubertal status. The objectives were to determine whether oral metformin treatment reduces BMI z score, cardiovascular risk, and inflammation biomarkers in children who are obese depending on pubertal stage and sex.
   METHODS: This was a randomized, prospective, double-blind, placebo-controlled, multicenter trial, stratified according to pubertal stage and sex, conducted at 4 Spanish clinical hospitals. Eighty prepubertal and 80 pubertal nondiabetic children who were obese aged 7 to 14 years with a BMI >95th percentiles were recruited. The intervention included 1 g/d of metformin versus placebo for 6 months. The primary outcome was a reduction in BMI z score. Secondary outcomes comprised insulin resistance, cardiovascular risk, and inflammation biomarkers.
   RESULTS: A total of 140 children completed the study (72 boys). Metformin decreased the BMI z score versus placebo in the prepubertal group (-0.8 and -0.6, respectively; difference, 0.2; P =.04). Significant increments were observed in prepubertal children treated with metformin versus placebo recipients in the quantitative insulin sensitivity check index (0.010 and -0.007; difference, 0.017; P =.01) and the adiponectin leptin ratio (0.96 and 0.15; difference, 0.81; P =.01) and declines in interferon -gamma (-5.6 and 0; difference, 5.6; P =.02) and total plasminogen activator inhibitor -1 (-1.7 and 2.4; difference, 4.1; P =.04). No serious adverse effects were reported.
   CONCLUSIONS: Metformin decreased the BMI z score and improved inflammatory and cardiovascular-related obesity parameters in prepubertal children but not in pubertal children. Ilence, the differential response according to puberty might be related to the dose of metformin per kilogram of weight. Further investigations are necessary.
C1 [Pastor-Villaescusa, Belen; Plaza-Diaz, Julio; Gil, Angel; Aguilera, Concepcion M.] Univ Granada, Ctr Biomed Res, Inst Nutr & Food Technol, Dept Biochem & Mol Biol 2, Granada, Spain.
   [Pastor-Villaescusa, Belen; Plaza-Diaz, Julio; Bueno, Gloria; Leis, Rosaura; Gil, Angel; Canete, Ramon; Aguilera, Concepcion M.] CIBER Fisiopatol Obesidad & Nutr CIBEROBN, Madrid, Spain.
   [Canete, M. Dolores] Maimonides Inst Biomed Res Cordoba IMIBIC, PAIDI CTS 329, Cordoba, Spain.
   [Caballero-Villarraso, Javier] Cordoba Univ, IMIBIC Reina Sofia Hosp, Clin Anal Serv, Cordoba, Spain.
   [Hoyos, Rayal] Virgen de las Nieves Univ Hosp, Andalusian Hlth Serv, Dept Pediat, Granada, Spain.
   [Maldonado, Jose] Virgen de las Nieves Univ Hosp, Andalusian Hlth Serv, Pediat Gastroenterol & Nutr Unit, Granada, Spain.
   [Latorre, Miriam] Hlth Sci Inst Aragon, Zaragoza, Spain.
   [Latorre, Miriam; Bueno, Gloria] Univ Zaragoza, Lozano Blesa Univ Clin Hosp, Dept Pediat, Zaragoza, Spain.
   [Vazquez-Cobela, Rocio; Leis, Rosaura] Univ Santiago Compostela, Clin Univ Hosp Santiago, Dept Pediat, Unit Invest Nutr Growth & Human Dev Galicia, Santiago De Compostela, Spain.
   [Gil, Angel; Aguilera, Concepcion M.] Inst Invest Biosanitaria Ibs GRANADA, Granada, Spain.
   [Canete, Ramon] Reina Sofia Univ Hosp, Unit Pediat Endocrinol, Cordoba, Spain.
C3 University of Granada; CIBER - Centro de Investigacion Biomedica en Red;
   CIBEROBN; Hospital Universitario Virgen de las Nieves; Hospital
   Universitario Virgen de las Nieves; University of Zaragoza; Lozano Blesa
   University Clinical Hospital; Complexo Hospitalario Universitario de
   Santiago de Compostela; Universidade de Santiago de Compostela;
   Instituto de Investigacion Biosanitaria IBS Granada; Hospital
   Universitario Reina Sofia - Cordoba
RP Aguilera, CM (corresponding author), Univ Granada, Inst Nutr & Food Technol, Ctr Biomed Res, Dept Biochem & Mol Biol 2,Lab 123, Ave Conocimiento S-N, Granada 18006, Spain.
EM caguiler@ugr.es
RI Latorre, Miriam/AAG-4162-2021; Leis, Rosaura/Z-3186-2019; BUENO,
   Maria/AAG-9985-2021; Pastor-Villaescusa, Belén/GRF-0832-2022;
   Caballero-Villarraso, Javier/AAC-3434-2019; Aguilera,
   Concepcion/M-1663-2014; Pastor Villaescusa, Belen/U-2325-2017; Gil,
   Angel/L-2275-2014; Vazquez Cobela, Rocio/ABF-5488-2020; Plaza-Diaz,
   Julio/C-8094-2016
OI Leis, Rosaura/0000-0002-0540-4210; Caballero-Villarraso,
   Javier/0000-0003-0571-5147; Aguilera, Concepcion/0000-0002-1451-4788;
   Pastor Villaescusa, Belen/0000-0003-0817-6804; Latorre-Millan,
   Miriam/0000-0001-9932-0124; Gil, Angel/0000-0001-7663-0939; Vazquez
   Cobela, Rocio/0000-0002-3155-1601; Plaza-Diaz, Julio/0000-0002-5171-9408
FU Spanish Ministry of Health, Social and Equality, General Department for
   Pharmacy and Health Products [EC-10-243, EC10-056, E6-10-281, EC10-227]
FX Funded by the Spanish Ministry of Health, Social and Equality, General
   Department for Pharmacy and Health Products (codes: EC-10-243, Dr
   Canete, Reina Sofia Hospital, Cordoba; EC10-056, Dr Gil, University of
   Granada and Virgen de las Nieves University Hospital, Granada;
   E6-10-281, Dr Leis, Clinic University Hospital of Santiago, Santiago de
   Compostela; and EC10-227, Dr Bueno, Lozano Blesa University Clinical
   Hospital, Zaragoza).
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NR 42
TC 46
Z9 49
U1 0
U2 13
PU AMER ACAD PEDIATRICS
PI Itasca
PA 345 Park Boulevard, Itasca, IL, UNITED STATES
SN 0031-4005
EI 1098-4275
J9 PEDIATRICS
JI Pediatrics
PD JUL
PY 2017
VL 140
IS 1
AR e20164285
DI 10.1542/peds.2017-1205
PG 10
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA EZ1PE
UT WOS:000404482500026
PM 28759403
OA Bronze
DA 2025-06-11
ER

PT J
AU Soliman, H
   Nyamandi, V
   Garcia-Patino, M
   Varela, JN
   Bankar, G
   Lin, GR
   Jia, ZP
   MacLeod, KM
AF Soliman, Hesham
   Nyamandi, Vongai
   Garcia-Patino, Marysol
   Varela, Julia Nogueira
   Bankar, Girish
   Lin, Guorong
   Jia, Zhengping
   MacLeod, Kathleen M.
TI Partial deletion of ROCK2 protects mice from high-fat diet-induced
   cardiac insulin resistance and contractile dysfunction
SO AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
LA English
DT Article
DE ROCK2; insulin signaling; heart; insulin receptor substrate
   phosphorylation
ID METABOLIC SYNDROME IMPACT; RHO-KINASE; RECEPTOR SUBSTRATE-1; TARGETED
   DISRUPTION; OXIDATIVE STRESS; INDUCED OBESITY; IN-VIVO; HEART; RATS;
   MECHANISMS
AB Obesity is associated with cardiac insulin resistance and contractile dysfunction, which contribute to the development of heart failure. The RhoA-Rho kinase (ROCK) pathway has been reported to modulate insulin resistance, but whether it is implicated in obesity-induced cardiac dysfunction is not known. To test this, wild-type (WT) and ROCK2(+/-) mice were fed normal chow or a high-fat diet (HFD) for 17 wk. Whole body insulin resistance, determined by an insulin tolerance test, was observed in HFD-WT, but not HFD-ROCK2(+/-), mice. The echocardiographically determined myocardial performance index, a measure of global systolic and diastolic function, was significantly increased in HFD-WT mice, indicating a deterioration of cardiac function. However, no change in myocardial performance index was found in hearts from HFD-ROCK2(+/-) mice. Speckle-tracking-based strain echocardiography also revealed regional impairment in left ventricular wall motion in hearts from HFD-WT, but not HFD-ROCK2(+/-), mice. Activity of ROCK1 and ROCK2 was significantly increased in hearts from HFD-WT mice, and GLUT4 expression was significantly reduced. Insulin-induced phosphorylation of insulin receptor substrate (IRS) Tyr(612), Akt, and AS160 was also impaired in these hearts, while Ser(307) phosphorylation of IRS was increased. In contrast, the increase in ROCK2, but not ROCK1, activity was prevented in hearts from HFD-ROCK2(+/-) mice, and cardiac levels of TNF alpha were reduced. This was associated with normalization of IRS phosphorylation, downstream insulin signaling, and GLUT4 expression. These data suggest that increased activation of ROCK2 contributes to obesity-induced cardiac dysfunction and insulin resistance and that inhibition of ROCK2 may constitute a novel approach to treat this condition.
C1 [Soliman, Hesham; Nyamandi, Vongai; Garcia-Patino, Marysol; Varela, Julia Nogueira; Bankar, Girish; Lin, Guorong; MacLeod, Kathleen M.] Univ British Columbia, Fac Pharmaceut Sci, Mol & Cellular Pharmacol Res Grp, Vancouver, BC V6T 1Z3, Canada.
   [Soliman, Hesham] Menia Univ, Fac Pharm, Dept Pharmacol & Toxicol, Al Minya, Egypt.
   [Jia, Zhengping] Univ Toronto, Hosp Sick Children, Neurosci & Mental Hlth, Toronto, ON M5G 1X8, Canada.
   [Jia, Zhengping] Univ Toronto, Fac Med, Dept Physiol, Toronto, ON M5S 1A8, Canada.
C3 University of British Columbia; Egyptian Knowledge Bank (EKB); Minia
   University; University of Toronto; Hospital for Sick Children
   (SickKids); University of Toronto
RP MacLeod, KM (corresponding author), Univ British Columbia, Fac Pharmaceut Sci, Vancouver, BC V6T 1Z3, Canada.
EM kmm@mail.ubc.ca
RI Jia, zhengping/AAZ-4190-2021; Varela, Julia/O-4302-2016
OI MacLeod, Kathleen/0000-0002-4280-6083; Soliman,
   Hesham/0009-0004-3562-2608
FU Canadian Institutes of Health Research [MOP 97861]; Canadian Diabetes
   Association; Mexican National Council for Science and Technology
   (CONACyT); CAPES Foundation, Ministry of Education, Brazil
FX This study was supported by operating grants from the Canadian
   Institutes of Health Research (MOP 97861) and from the Canadian Diabetes
   Association to K. M. MacLeod. V. Nyamandi is supported by a doctoral
   student research award from the Canadian Diabetes Association, M.
   Garcia-Patino and J. N. Varela are supported by Ph.D. scholarships from
   the Mexican National Council for Science and Technology (CONACyT) and
   the CAPES Foundation, Ministry of Education, Brazil, respectively.
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NR 50
TC 30
Z9 33
U1 0
U2 11
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0363-6135
EI 1522-1539
J9 AM J PHYSIOL-HEART C
JI Am. J. Physiol.-Heart Circul. Physiol.
PD JUL 1
PY 2015
VL 309
IS 1
BP H70
EP H81
DI 10.1152/ajpheart.00664.2014
PG 12
WC Cardiac & Cardiovascular Systems; Physiology; Peripheral Vascular
   Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Physiology
GA CM2IG
UT WOS:000357502700007
PM 25910808
DA 2025-06-11
ER

PT J
AU Elkum, N
   Al-Arouj, M
   Sharifi, M
   Behbehani, K
   Bennakhi, A
AF Elkum, N.
   Al-Arouj, M.
   Sharifi, M.
   Behbehani, K.
   Bennakhi, A.
TI Cardiovascular disease risk factors in the South Asian population living
   in Kuwait: a cross-sectional study
SO DIABETIC MEDICINE
LA English
DT Article
ID IMPAIRED GLUCOSE-TOLERANCE; FAMILY-HISTORY; INSULIN-RESISTANCE;
   METABOLIC SYNDROME; PREVALENCE; INDIANS; PREVENTION; HEALTH;
   ATHEROSCLEROSIS; OBESITY
AB Background
   High rates of diabetes and cardiovascular disease have been reported in South Asian immigrants in many countries. However, the prevalence and characteristics of cardiovascular disease risk factors among a South Asian population living in Kuwait have not yet been investigated. This study was therefore designed to estimate the prevalence of cardiovascular disease risk factors and determine whether they are independently associated with diabetes in such a population.
   Methods
   A population-based cross-sectional study was conducted on 1094 South Asians (781 men and 313 women), mainly Indian and Pakistani (>= 18years of age), of whom 75.1% were Indians. Interviews were carried out, during which socio-demographic and anthropometric data were collected, followed by a physical examination and collection of fasting blood samples for laboratory investigations. Diabetes was defined by fasting plasma glucose >= 7mmol/l, or being on treatment, and/or self-reported previously diagnosed Type2 diabetes.
   Results
   The prevalence of diabetes was 21.1%, with 3.4% of that percentage of people being newly diagnosed. Using BMI measurements, 24.0% of those who participated in the study were obese and 46.1% were overweight. Dyslipidaemia was found in 77.6% and hypertension in 44.8%. Advancing age (>= 40years), male gender, high LDL, high total cholesterol, hypertension and positive family history of diabetes were significantly associated with increased risk of diabetes.
   Conclusion
   Our study shows that the prevalence of cardiovascular disease risk factors in South Asian expatriates in Kuwait exceeds prevalence rates reported in their homeland and other countries. This may suggest the added stress of environmental factors on the development of cardiovascular disease risk factors in such populations. Specialized prevention programmes targeting such high-risk ethnic populations are paramount and need to be implemented.
C1 [Elkum, N.; Al-Arouj, M.; Sharifi, M.; Behbehani, K.; Bennakhi, A.] Dasman Diabet Inst, Kuwait, Kuwait.
C3 Dasman Diabetes Institute (DDI)
RP Elkum, N (corresponding author), Dasman Diabet Inst, Kuwait, Kuwait.
EM nelkum@hotmail.com
RI Elkum, Naser/AAU-5555-2020
OI Elkum, Naser/0000-0002-0457-0444
FU Kuwait Foundation for the Advancement of Sciences (KFAS)
FX This study was supported by the Kuwait Foundation for the Advancement of
   Sciences (KFAS).
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NR 31
TC 14
Z9 14
U1 0
U2 13
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0742-3071
EI 1464-5491
J9 DIABETIC MED
JI Diabetic Med.
PD MAY
PY 2014
VL 31
IS 5
BP 531
EP 539
DI 10.1111/dme.12386
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA AE6QD
UT WOS:000334117700005
PM 24344774
DA 2025-06-11
ER

PT J
AU Eller, LK
   Saha, DC
   Shearer, J
   Reimer, RA
AF Eller, Lindsay K.
   Saha, Dolan C.
   Shearer, Jane
   Reimer, Raylene A.
TI Dietary leucine improves whole-body insulin sensitivity independent of
   body fat in diet-induced obese Sprague-Dawley rats
SO JOURNAL OF NUTRITIONAL BIOCHEMISTRY
LA English
DT Article
DE Obesity; Insulin sensitivity; Dairy; Leucine; Calcium
ID CALCIUM SUPPLEMENTATION; METABOLIC SYNDROME; DAIRY CONSUMPTION;
   INFLAMMATORY STRESS; WEIGHT-GAIN; RESISTANCE; PATHWAY; MICE;
   HYPERGLYCEMIA; ADIPOCYTES
AB Dairy foods and dietary calcium (Ca) are potential regulators of body weight and insulin sensitivity. The specific components of dairy responsible for these actions are not known but may include leucine. Our objective was to determine the effect of dietary protein (casein, skim milk or leucine) and Ca level [low, 0.67% (LC) or high, 2.4% (HC)] on adiposity and insulin sensitivity. Obesity was induced in Sprague-Dawley rats with a 6-week period of high-fat/high-sucrose (HFHS) diet intake. Rats were randomly assigned to one of six HFHS diets for 8 weeks where dietary protein was provided as casein, skim milk or casein enriched with leucine, and contained either LC or HC. Body composition via dual-energy x-ray absorptiometry and insulin sensitivity via euglycemic-hyperinsulinemic clamp were measured. Microarray was used to assess gene expression in liver and skeletal muscle. Rats fed leucine had greater insulin sensitivity than those fed casein or skim milk (P<.05). Dietary protein differentially regulated hepatic and skeletal muscle genes associated with insulin, peroxisome proliferator-activated receptor and mammalian target of rapamycin pathways. Specifically, two key genes responsible for insulin sensitivity, hepatic insulin receptor substrate (IRS) and protein kinase B (Akt), were altered in hepatic tissue in response to leucine. Rats fed skim milk and leucine diets had lower body weight compared to those fed casein (P<.05). HC reduced fat mass compared to LC (P<.05). While skim milk and leucine both reduced fat mass, only leucine improved insulin sensitivity compared to casein. Differential expression of genes such as IRS and Akt may be responsible for changes in insulin sensitivity in obese rats. (C) 2013 Elsevier Inc. All rights reserved.
C1 [Eller, Lindsay K.; Shearer, Jane; Reimer, Raylene A.] Univ Calgary, Fac Med, Dept Biochem & Mol Biol, Calgary, AB T2N 1N4, Canada.
   [Saha, Dolan C.; Shearer, Jane; Reimer, Raylene A.] Univ Calgary, Fac Kinesiol, Calgary, AB T2N 1N4, Canada.
C3 University of Calgary; University of Calgary
RP Reimer, RA (corresponding author), Univ Calgary, Fac Kinesiol, 2500 Univ Dr NW, Calgary, AB T2N 1N4, Canada.
EM reimer@ucalgary.ca
OI Reimer, Raylene/0000-0001-5088-7947
FU Dairy Farmers of Canada; Natural Sciences and Engineering Research
   Council of Canada (NSERC); NSERC; Canadian Diabetes Association; Alberta
   Innovates-Health Solutions (AIHS); Alberta Children's Hospital Research
   Institute for Maternal and Child Health CIHR; Heart and Stroke
   Foundation of Canada (HSF); Canadian Institutes for Health Research
   (CIHR)
FX D.C.S., J.S. and L.K.E. have no potential conflicts of interest to
   disclose. R.A.R. previously held a grant from the Dairy Farmers of
   Canada for work distinct from this current study. Thank you to Robyn Lee
   and Virginia Berry for technical assistance in immunoblotting.This work
   was supported by funding from the Natural Sciences and Engineering
   Research Council of Canada (NSERC). L.K.E. was supported by a doctoral
   fellowship from NSERC and the Canadian Diabetes Association. D.C.S. is
   supported by postdoctoral fellowships from the Alberta Innovates-Health
   Solutions (AIHS) and the Alberta Children's Hospital Research Institute
   for Maternal and Child Health CIHR training grant. J.S. is funded by
   NSERC, Alberta Innovates-Health Solutions (AIHS), The Heart and Stroke
   Foundation of Canada (HSF) and The Canadian Institutes for Health
   Research (CIHR).
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NR 42
TC 32
Z9 32
U1 0
U2 32
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0955-2863
EI 1873-4847
J9 J NUTR BIOCHEM
JI J. Nutr. Biochem.
PD JUL
PY 2013
VL 24
IS 7
BP 1285
EP 1294
DI 10.1016/j.jnutbio.2012.10.004
PG 10
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA 177YZ
UT WOS:000321412600011
PM 23332601
DA 2025-06-11
ER

PT J
AU Yoshino, S
   Hamasaki, S
   Ishida, S
   Kataoka, T
   Yoshikawa, A
   Oketani, N
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   Fujita, S
   Takumi, T
   Yoshimoto, I
   Nakazaki, M
   Tei, C
AF Yoshino, Satoshi
   Hamasaki, Shuichi
   Ishida, Sanemasa
   Kataoka, Tetsuro
   Yoshikawa, Akiko
   Oketani, Naoya
   Saihara, Keishi
   Ichiki, Hitoshi
   Kuwahata, So
   Fujita, Shoji
   Takumi, Takuro
   Yoshimoto, Issei
   Nakazaki, Mitsuhiro
   Tei, Chuwa
TI Characterization of the effect of serum bilirubin concentrations on
   coronary endothelial function via measurement of high-sensitivity
   C-reactive protein and high-density lipoprotein cholesterol
SO HEART AND VESSELS
LA English
DT Article
DE Bilirubin; Endothelial dysfunction; Coronary artery disease;
   High-density lipoprotein cholesterol; High-sensitivity C-reactive
   protein
ID CAROTID ATHEROSCLEROSIS; METABOLIC SYNDROME; RISK; ASSOCIATION;
   ANTIOXIDANT; DYSFUNCTION; RESISTANCE; INFLAMMATION; CHILDREN; OBESE
AB Bilirubin can prevent oxidation of low-density lipoprotein (LDL) and may protect against atherosclerosis and coronary heart disease (CHD). The goal of this study was to characterize the relationship between bilirubin and CHD through measurements of bilirubin concentration, coronary endothelial function, and markers of oxidative stress, inflammation, and lipid/glucose metabolism. The study population consisted of 141 patients without CHD who underwent Doppler flow study. Vascular reactivity was examined by intracoronary administration of papaverine, acetylcholine (ACh) and nitroglycerin using a Doppler guide wire. Serum bilirubin, high-sensitivity C-reactive protein (hsCRP), malondialdehyde-modified LDL, LDL cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), fasting plasma glucose (FPG), and immunoreactive insulin were also measured. Homeostasis model assessment insulin resistance index and estimated glomerular filtration rate (eGFR) were calculated. Univariate analysis revealed that both percent change in coronary blood flow (CBF) and coronary artery diameter induced by ACh correlated positively with log-transformed bilirubin (r = 0.22, P < 0.05; r = 0.20, P < 0.05, respectively). Percent change in CBF in response to ACh correlated positively with eGFR (r = 0.24, P < 0.05) and correlated inversely with age, LDL-C, and log-transformed FPG (r = -0.24, P < 0.05; r = -0.17, P < 0.05, r = -0.22, P < 0.05, respectively). Multivariate analysis revealed that log-transformed bilirubin was the only independent predictor of percent change in CBF in response to ACh. Multivariate analysis revealed that log-transformed hsCRP and HDL-C were independent predictors of log-transformed bilirubin. These results suggest that a high level of bilirubin is associated with favorable coronary endothelial function, which may be mediated via the effect of bilirubin on inflammation and HDL-C.
C1 [Yoshino, Satoshi; Hamasaki, Shuichi; Ishida, Sanemasa; Kataoka, Tetsuro; Yoshikawa, Akiko; Oketani, Naoya; Saihara, Keishi; Ichiki, Hitoshi; Kuwahata, So; Fujita, Shoji; Takumi, Takuro; Yoshimoto, Issei; Nakazaki, Mitsuhiro; Tei, Chuwa] Kagoshima Univ, Dept Cardiovasc Resp & Metab Med, Grad Sch Med, Kagoshima 8908520, Japan.
C3 Kagoshima University
RP Hamasaki, S (corresponding author), Kagoshima Univ, Dept Cardiovasc Resp & Metab Med, Grad Sch Med, 8-35-1 Sakuragaoka, Kagoshima 8908520, Japan.
EM hamasksh@m.kufm.kagoshima-u.ac.jp
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NR 34
TC 16
Z9 19
U1 0
U2 12
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0910-8327
EI 1615-2573
J9 HEART VESSELS
JI Heart Vessels
PD MAR
PY 2013
VL 28
IS 2
BP 157
EP 165
DI 10.1007/s00380-011-0228-z
PG 9
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 108KM
UT WOS:000316291800004
PM 22457095
DA 2025-06-11
ER

PT J
AU Eguchi, Y
   Mizuta, T
   Sumida, Y
   Ishibashi, E
   Kitajima, Y
   Isoda, H
   Horie, H
   Tashiro, T
   Iwamoto, E
   Takahashi, H
   Kuwashiro, T
   Soejima, S
   Kawaguchi, Y
   Oda, Y
   Emura, S
   Iwakiri, R
   Ozaki, I
   Eguchi, T
   Ono, N
   Anzai, K
   Fujimoto, K
   Koizumi, S
AF Eguchi, Yuichiro
   Mizuta, Toshihiko
   Sumida, Yoshio
   Ishibashi, Eriko
   Kitajima, Yoichiro
   Isoda, Hiroshi
   Horie, Hiroko
   Tashiro, Takaya
   Iwamoto, Eri
   Takahashi, Hirokazu
   Kuwashiro, Takuya
   Soejima, Shu
   Kawaguchi, Yasunori
   Oda, Yasutomo
   Emura, Sei
   Iwakiri, Ryuichi
   Ozaki, Iwata
   Eguchi, Takahisa
   Ono, Naofumi
   Anzai, Keizo
   Fujimoto, Kazuma
   Koizumi, Shunzo
TI The pathological role of visceral fat accumulation in steatosis,
   inflammation, and progression of nonalcoholic fatty liver disease
SO JOURNAL OF GASTROENTEROLOGY
LA English
DT Article
DE Abdominal obesity; Central obesity; Adipocytokine; Metabolic syndrome;
   Oxidative stress
ID SERUM AMINOTRANSFERASE CONCENTRATION; INSULIN-RESISTANCE; JAPANESE
   PATIENTS; IRON OVERLOAD; STEATOHEPATITIS; ADIPONECTIN; SPECTRUM;
   SEVERITY; DAMAGE; WOMEN
AB Our previous studies have indicated a close association between visceral fat accumulation and hepatic steatosis in nonalcoholic fatty liver disease (NAFLD). This study investigated whether visceral fat accumulation was related to the pathogenesis and disease progression of nonalcoholic steatohepatitis (NASH)/NAFLD.
   First, a total of 550 subjects who underwent a health checkup and measurement of visceral fat accumulation, done with a bioelectrical impedance analyzer (X-SCAN; Owa Medical, Fukuoka, Japan), were included. The relationship between visceral fat accumulation and biochemical parameters was examined. Second, a total of 74 patients with NASH/NAFLD who underwent liver biopsy were reviewed. Visceral fat accumulation was determined by abdominal computed tomography. The association between visceral fat accumulation and the histopathological grade/stage determined by the NAFLD activity score and Brunt's classification was evaluated.
   There was a significant relationship between visceral fat accumulation and glucose, triglyceride, and alanine aminotransferase (ALT; r = 0.423, P < 0.01). In stepwise regression analysis, visceral fat area (VFA), serum triglyceride level, and serum low-density lipoprotein (LDL)-cholesterol level were selected as predictor variables for serum ALT level, in a continuous manner (serum ALT level = -1.359 + 0.143 x VFA + 0.046 x triglyceride + 0.059 x LDL, R (2) = 0.217, P < 0.001). In patients with NASH, there was no correlation between histological grade and the visceral fat volume. Visceral fat accumulation in patients with stage 3/4 advanced NASH was greater than that in patients with stage 1/2 early NASH (P < 0.05).
   These results suggest that visceral fat accumulation plays a role in steatosis and fibrosis in the pathogenesis and prognosis of NAFLD.
C1 [Eguchi, Yuichiro; Soejima, Shu; Oda, Yasutomo; Emura, Sei; Koizumi, Shunzo] Saga Med Sch, Dept Gen Med, Saga 8498501, Japan.
   [Mizuta, Toshihiko; Ishibashi, Eriko; Kitajima, Yoichiro; Isoda, Hiroshi; Takahashi, Hirokazu; Kuwashiro, Takuya; Kawaguchi, Yasunori; Iwakiri, Ryuichi; Ozaki, Iwata; Anzai, Keizo; Fujimoto, Kazuma] Saga Med Sch, Dept Internal Med, Saga 8498501, Japan.
   [Sumida, Yoshio] Nara City Hosp, Ctr Digest Dis & Liver Dis, Nara, Japan.
   [Ishibashi, Eriko; Kitajima, Yoichiro; Isoda, Hiroshi; Horie, Hiroko; Tashiro, Takaya; Iwamoto, Eri; Eguchi, Takahisa; Ono, Naofumi] Eguchi Hosp, Saga, Japan.
C3 Saga University; Saga University
RP Eguchi, Y (corresponding author), Saga Med Sch, Dept Gen Med, 5-1-1 Nabeshima, Saga 8498501, Japan.
EM eguchiyu@cc.saga-u.ac.jp
RI Sumida, Yoshio/AAL-6723-2020
OI Takahashi, Hirokazu/0000-0003-1900-4389
CR BROWNING LM, 2010, OBESITY         0401
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NR 34
TC 53
Z9 58
U1 1
U2 8
PU SPRINGER JAPAN KK
PI TOKYO
PA CHIYODA FIRST BLDG EAST, 3-8-1 NISHI-KANDA, CHIYODA-KU, TOKYO, 101-0065,
   JAPAN
SN 0944-1174
J9 J GASTROENTEROL
JI J. Gastroenterol.
PD JAN
PY 2011
VL 46
SU 1
BP 70
EP 78
DI 10.1007/s00535-010-0340-3
PG 9
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 685RS
UT WOS:000284646400011
PM 21042922
DA 2025-06-11
ER

PT J
AU Tsugita, M
   Iwasaki, Y
   Nishiyama, M
   Taguchi, T
   Shinahara, M
   Taniguchi, Y
   Kambayashi, M
   Terada, Y
   Hashimoto, K
AF Tsugita, Makoto
   Iwasaki, Yasumasa
   Nishiyama, Mitsuru
   Taguchi, Takafumi
   Shinahara, Masayuki
   Taniguchi, Yoshinori
   Kambayashi, Machiko
   Terada, Yoshio
   Hashimoto, Kozo
TI Differential regulation of 11β-hydroxysteroid dehydrogenase type-1 and
   -2 gene transcription by proinflammatory cytokines in vascular smooth
   muscle cells
SO LIFE SCIENCES
LA English
DT Article
DE 11 beta-hydroxysteroid dehydrogenase; glucocortcoid; cytokine; smooth
   muscle
ID NF-KAPPA-B; RECEPTOR GENE; RECIPROCAL REGULATION; METABOLIC SYNDROME;
   FACTOR-ALPHA; EXPRESSION; ALDOSTERONE; INDUCTION; PROMOTER; OBESITY
AB Glucocorticoid hormone is activated by 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD-1) mainly in glucocorticoid-target organs such as the liver and the anterior corticotroph cells, and inactivated by type 2 (11 beta-HSD-2) in mineralocorticoid-target cells such as renal and colonic epithelial cells. In this study, we examined the expression and action of these glucocorticoid-metabolizing enzymes in the A10 rat aortic smooth muscle cells (VSMC) in vitro. We found that both 11 beta-HSD-1 and -2 mRNAs as well as glucocorticoid receptor (GR) and mineralocorticoid receptor (MR) were expressed in the cells. Interestingly, the transcriptional activity of 11 beta-HSD-1 was stimulated by a representative proinflammatory cytokine TNF alpha, and inflammation-related inducible transcription factors AP1 and C/EBPs might have been at least partly responsible for the effect. In contrast, the transcriptional activity of 11 beta-HSD-2 was decreased during the same stimuli, and another inflammation-induced transcription factor Egr-1 might have mediated the effect by interfering with the effect of Sp1, which maintains the basal expression of 11 beta-HSD-2. The increase and decrease in 11 beta-HSD-1 and 11 beta-HSD-2 expression during inflammatory stimuli, respectively, were expected to cause the enhancement in glucorcorticorid action, which was confirmed by the fact that TNF alpha elicited the cortisone-to-cortisol conversion using our bioassay system which employs the glucocorticoid-responsive reporter gene. Altogether, our results strongly suggest that inflammatory stress facilitates the intracellular glucocorticoid activation, i.e. conversion from inactive cortisone to active cortisol, by modifying the expression of both 11 beta-HSD-1 and 11 beta-HSD-2. (c) 2008 Elsevier Inc. All rights reserved.
C1 [Tsugita, Makoto; Iwasaki, Yasumasa; Nishiyama, Mitsuru; Taguchi, Takafumi; Shinahara, Masayuki; Taniguchi, Yoshinori; Kambayashi, Machiko; Terada, Yoshio; Hashimoto, Kozo] Kochi Univ, Kochi Med Sch, Dept Endocrinol Metab & Nephrol, Nankoku, Kochi 7838505, Japan.
C3 Kochi University
RP Iwasaki, Y (corresponding author), Kochi Univ, Kochi Med Sch, Dept Endocrinol Metab & Nephrol, Nankoku, Kochi 7838505, Japan.
EM iwasaki@kochi-u.ac.jp
RI Nishiyama, Mitsuru/GRF-4962-2022
OI Nishiyama, Mitsuru/0000-0003-4417-7476
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NR 37
TC 24
Z9 25
U1 0
U2 4
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0024-3205
EI 1879-0631
J9 LIFE SCI
JI Life Sci.
PD SEP 12
PY 2008
VL 83
IS 11-12
BP 426
EP 432
DI 10.1016/j.lfs.2008.07.005
PG 7
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA 352SQ
UT WOS:000259518100007
PM 18692075
DA 2025-06-11
ER

PT J
AU Bhoir, SA
   Sharma, D
   Jamdar, S
AF Bhoir, Shraddha A.
   Sharma, Deepak
   Jamdar, Sahayog
TI Millets, pulses, and oil seeds-based flatbread premix: A protein-rich
   functional food for healthier dietary habits and prevention of lifestyle
   disorders
SO JOURNAL OF FOOD SCIENCE
LA English
DT Article
DE functional foods; immunomodulation; millets and pulses; nutrition and
   health
ID METABOLIC SYNDROME; PASTING PROPERTIES; HIGH-FAT; MICROBIOTA; STABILITY;
   FLAXSEED; FLOUR; CELL
AB With an increasing focus on healthier dietary alternatives, this study developed a protein-rich, ready-to-cook flatbread premix using millet, pulse, and oilseed flours. The premix offers a balanced nutritional profile, providing high protein content (similar to 21%) and delivering 423 kcal/100 g. It demonstrated phenolic content of 0.98 mg catechin equivalents/gram of premix, which increased to 1.90 mg catechin equivalents/gram of cooked (lyophilized) product.
   Antioxidant activity was evaluated through DPPH radical scavenging, yielding values of 5.28 nmol Trolox equivalents per gram for the premix and 4.82 nmol Trolox equivalents per gram for the cooked product. Similarly, hydroxyl radical scavenging activity was measured at 4.38 mu mol Trolox equivalents per gram for the premix and 4.36 mu mol Trolox equivalents per gram for the cooked product. The product was highly acceptable in sensory evaluations, indicating strong potential for consumer adoption. In vivo studies with Balb/c mice revealed no adverse effects on oxidative stress levels or immune function. The flatbread promoted a healthy gut microbiota composition, supporting gut health while maintaining cellular oxidative balance. Hematological analyses showed improved white blood cell and lymphocyte counts, reflecting enhanced immune resilience.
   These findings highlight the premix as a promising dietary alternative to traditional carbohydrate-rich staples. With its nutrient density and functional benefits, the flatbread premix offers a practical solution for improving dietary habits and addressing lifestyle-related health concerns. This study underscores the importance of incorporating such functional foods into daily diets to promote better health and prevent nutrition-related disorders. Further research is warranted to explore its broader health impacts over extended durations.
C1 [Bhoir, Shraddha A.; Jamdar, Sahayog] Bhabha Atom Res Ctr, Food Technol Div, Mumbai 400085, India.
   [Sharma, Deepak] Bhabha Atom Res Ctr, Radiat Biol & Hlth Sci Div, Mumbai, India.
   [Bhoir, Shraddha A.; Sharma, Deepak; Jamdar, Sahayog] Homi Bhabha Natl Inst, Mumbai, India.
C3 Bhabha Atomic Research Center (BARC); Bhabha Atomic Research Center
   (BARC); Homi Bhabha National Institute
RP Bhoir, SA (corresponding author), Bhabha Atom Res Ctr, Food Technol Div, Mumbai 400085, India.
EM bhoirsa@barc.gov.in
FU Bhabha Atomic Research Centre; Bhabha Atomic Research Centre, Department
   of Atomic Energy
FX The authors would like to acknowledge the support provided by the Bhabha
   Atomic Research Centre, Department of Atomic Energy, Govt. of India.
   This research was made possible through their funding, facilities, and
   infrastructure, which enabled the completion of the study. Additionally,
   we extend our gratitude to Ms. Shalakha John, Ms. Antra Thada, and Ms.
   Babita Singh, Radiation Biology and Health Sciences Division, BARC and
   Dr. Mallikarjunan N., Food Technology Division, BARC, for their valuable
   assistance and guidance throughout the course of this research. We also
   express our appreciation to Mr. Deepak Katole, Mr. B. A. Naidu, and Mrs.
   Manisha Indulkar, who contributed through their technical assistance.
   Their contributions have enriched the quality of our work and are
   sincerely appreciated.
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NR 66
TC 0
Z9 0
U1 1
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-1147
EI 1750-3841
J9 J FOOD SCI
JI J. Food Sci.
PD APR
PY 2025
VL 90
IS 4
AR e70209
DI 10.1111/1750-3841.70209
PG 16
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA 2BA3N
UT WOS:001478381100016
PM 40271796
DA 2025-06-11
ER

PT J
AU Yang, YJ
   Zheng, XW
   Lv, HY
   Tang, B
   Bi, Y
   Luo, QQ
   Yao, DN
   Chen, HM
   Lu, CJ
AF Yang, Yujie
   Zheng, Xuwei
   Lv, Haiying
   Tang, Bin
   Bi, Yang
   Luo, Qianqian
   Yao, Danni
   Chen, Haiming
   Lu, Chuanjian
TI A bibliometrics study on the status quo and hot topics of pathogenesis
   of psoriasis based on Web of Science
SO SKIN RESEARCH AND TECHNOLOGY
LA English
DT Article
DE bibliometrics; CiteSpace; pathogenesis; psoriasis; VOSviewer
ID ENDOPLASMIC-RETICULUM STRESS; LONG NONCODING RNA; GUT MICROBIOTA;
   PROMOTES; INHIBITION; EXPRESSION; VULGARIS
AB BackgroundPsoriasis is an immune-mediated chronic inflammatory skin disease. Great progress has been made in the pathogenesis of psoriasis in recent years, but there is no bibliometric study on the pathogenesis of psoriasis. The purpose of this study was to use bibliometrics method to analyze the research overview and hot spots of pathogenesis of psoriasis in recent 10 years, so as to further understand the development trend and frontier of this field.MethodsThe core literatures on the pathogenesis of psoriasis were searched in the Web of Science database, and analyzed by VOSviewer, CiteSpace, and Bibliometrix in terms of the annual publication volume, country, institution, author, journal, keywords, and so on.ResultsA total of 3570 literatures were included. China and the United States were the main research countries in this field, and Rockefeller University was the main research institution. Krueger JG, the author, had the highest number of publications and the greatest influence, and Boehncke (2015) was the most cited local literature. J INVEST DERMATOL takes the top spot in terms of the number of Dermatol articles and citation frequency. The main research hotspots in the pathogenesis of psoriasis are as follows: (1) The interaction between innate and adaptive immunity and the related inflammatory loop dominated by Th17 cells and IL-23/IL-17 axis are still the key mechanisms of psoriasis; (2) molecular genetic studies represented by Long Non-Coding RNA (LncRNA); (3) integrated research of multi-omics techniques represented by gut microbiota; and (4) Exploring the comorbidity mechanism of psoriasis represented by Metabolic Syndrome (MetS).ConclusionThis study is a summary of the current research status and hot trend of the pathogenesis of psoriasis, which will provide some reference for the scholars studying the pathogenesis of psoriasis.
C1 [Yang, Yujie; Zheng, Xuwei; Lv, Haiying; Tang, Bin; Bi, Yang; Luo, Qianqian; Yao, Danni; Chen, Haiming; Lu, Chuanjian] Guangzhou Univ Chinese Med, Clin Coll 2, Guangzhou, Peoples R China.
   [Tang, Bin; Yao, Danni; Chen, Haiming; Lu, Chuanjian] Guangzhou Univ Chinese Med, Affiliated Hosp 2, Guangdong Prov Hosp Chinese Med, State Key Lab Dampness Syndrome Chinese Med, Guangzhou, Peoples R China.
   [Tang, Bin; Yao, Danni; Chen, Haiming; Lu, Chuanjian] Guangdong Prov Key Lab Clin Res Tradit Chinese Med, Guangzhou, Peoples R China.
   [Tang, Bin; Yao, Danni; Chen, Haiming; Lu, Chuanjian] Guangdong Prov Clin Med Res Ctr Chinese Med Dermat, Guangzhou, Peoples R China.
   [Tang, Bin; Yao, Danni; Chen, Haiming; Lu, Chuanjian] Guangzhou Univ Chinese Med, Guangdong Hong Kong Macau Joint Lab Chinese Med &, Guangzhou, Peoples R China.
C3 Guangzhou University of Chinese Medicine; Guangzhou University of
   Chinese Medicine; Guangzhou University of Chinese Medicine
RP Chen, HM; Lu, CJ (corresponding author), Guangzhou Univ Chinese Med, Clin Coll 2, Guangzhou, Peoples R China.
EM hemin066@gzucm.edu.cn; lcj@gzucm.edu.cn
FU Research Fund for Bajian Talents of Guangdong Provincial Hospital of
   Chinese Medicine; Science and Technology Planning Project of Guangzhou
   [202201020353, 202206080006]; Science and Technology Planning Project of
   Guangdong Province [2020B1212030006, 2020B1111170012, 2023B1212060063];
   Chinese Medicinal Scientific Research Project of Guangdong Province
   [20211176, 20211185]; Technology Research Projects of Guangdong
   Provincial Hospital of Chinese Medicine [YN2019QJ08, YN2019QL11];
   Technology Research Projects of State Key laboratory of Dampness
   Syndrome of Chinese Medicine [SZ2021ZZ34, SZ2021ZZ45]; Guangzhou Basic
   Research Program [202102010335]
FX We thank all authors who participated in the study on pathogenesis of
   psoriasis. The research was partially supported by grants from Research
   Fund for Bajian Talents of Guangdong Provincial Hospital of Chinese
   Medicine (No.BJ2022KY02), the Science and Technology Planning Project of
   Guangzhou (No.202201020353 & 202206080006), the Science and Technology
   Planning Project of Guangdong Province (Nos. 2020B1212030006 &
   2020B1111170012 & 2023B1212060063 ), the Chinese Medicinal Scientific
   Research Project of Guangdong Province (Nos.20211176 & 20211185), the
   Technology Research Projects of Guangdong Provincial Hospital of Chinese
   Medicine (Nos. YN2019QJ08 & YN2019QL11), Technology Research Projects of
   State Key laboratory of Dampness Syndrome of Chinese Medicine (Nos.
   SZ2021ZZ34 & SZ2021ZZ45), and Guangzhou Basic Research Program
   (202102010335).
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NR 73
TC 13
Z9 13
U1 62
U2 177
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0909-752X
EI 1600-0846
J9 SKIN RES TECHNOL
JI Skin Res. Technol.
PD JAN
PY 2024
VL 30
IS 1
AR e13538
DI 10.1111/srt.13538
PG 13
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA EB0D8
UT WOS:001136318900001
PM 38174774
OA hybrid
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Farrokhfall, K
   Ataei, Z
   Asadi, M
   Talebpour, A
   Nakhaee, S
   Mohammadifard, M
   Rezapour, H
   Zahmatipour, F
   Mohammadpour, N
   Ferns, GA
   Bahrami, A
AF Farrokhfall, Khadijeh
   Ataei, Zommorod
   Asadi, Mahla
   Talebpour, Amir
   Nakhaee, Samaneh
   Mohammadifard, Mahtab
   Rezapour, Hadis
   Zahmatipour, Faezeh
   Mohammadpour, Nafiseh
   Ferns, Gordon A.
   Bahrami, Afsane
TI A randomised controlled trial of the effects of curcumin on nitric oxide
   levels in women with premenstrual syndrome and dysmenorrhoea
SO JOURNAL OF HERBAL MEDICINE
LA English
DT Article
DE Menstrual pain; Iron; Turmeric; Diet; Total iron-binding capacity
ID ADRENOMEDULLIN LEVELS; METABOLIC SYNDROME; OXIDATIVE STRESS;
   DOUBLE-BLIND; PAIN; MODULATION; THERAPY; BLOOD; INFLAMMATION; PREVALENCE
AB Introduction: Symptoms of primary dysmenorrhoea (PD) and premenstrual syndrome (PMS) are common gynaecologic complaints in women. It has been proposed that they may be related to nitric oxide (NO) release. We aimed to investigate the effects of curcumin, as an anti-inflammatory and antioxidant natural product, on the levels of serum NO metabolites in young women with PD and PMS. Methods: A randomised, triple-blinded, placebo-controlled clinical trial was performed. Women who suffered from both PMS and PD were enroled and received curcumin (n = 38), or placebo (n = 38), as capsules daily (500 mg of curcuminoid plus piperine, or placebo) from 7 days pre-until 3 days postmenstruation for three successive menstrual cycles. The dietary intake, as well as biochemical and haematological parameters was evaluated by standard procedures. Serum NOx (nitrite & PLUSMN; nitrate) was measured using the Griess assay. Results: At baseline, there were no significant differences between the curcumin and placebo groups with respect to age, dietary intake, and NOx levels. A significant decrement was found in serum concentrations of NOx (93.3 & PLUSMN; 37.4 to 85.9 & PLUSMN; 28.9; P = 0.048) after curcuminoid supplementation, but this was not the case for the placebo group, NOx levels remained unaltered by the end of the trial (72.4 & PLUSMN; 42.5 to 68.4 & PLUSMN; 32.9; P = 0.32). However, the between-group analysis showed no significant differences in the NOx index (P = 0.36). A significant direct correlation was found between PMS pain and NOx levels only in the curcumin group (Pearson's r = 0.34; P = 0.042). Conclusions: Curcuminoid-piperine supplementation may cause a reduction in serum NOx levels in young women with PD and PMS.
C1 [Farrokhfall, Khadijeh; Nakhaee, Samaneh] Birjand Univ Med Sci, Fac Med, Med Toxicol & Drug Abuse Res Ctr MTDRC, Dept Physiol, Birjand, Iran.
   [Ataei, Zommorod] Islamic Azad Univ, Fac Med, Dept Basic Sci, Zahedan Branch, Zahedan, Iran.
   [Asadi, Mahla] Mashhad Univ Med Sci, Fac Med, Dept Biochem, Mashhad, Iran.
   [Talebpour, Amir; Rezapour, Hadis; Zahmatipour, Faezeh; Mohammadpour, Nafiseh] Birjand Univ Med Sci, Student Res Comm, Dept Environm Hlth Engn, Birjand, Iran.
   [Mohammadifard, Mahtab] Birjand Univ Med Sci, Infect Dis Res Ctr, Birjand, Iran.
   [Ferns, Gordon A.] Brighton & Sussex Med Sch, Dept Med Educ, Brighton BN1 9PH, Sussex, England.
   [Bahrami, Afsane] Mashhad Univ Med Sci, Clin Res Dev Unit, Dept Biochem, Akbar Hosp, Mashhad, Iran.
   [Bahrami, Afsane] Mashhad Univ Med Sci, Imam Reza Hosp, Fac Med, Clin Res Unit, Mashhad, Iran.
   [Bahrami, Afsane] Mashhad Univ Med Sci, Imam Reza Hosp, Fac Med, Clin Res Dev Unit, Mashhad 9137913316, Iran.
C3 Birjand University of Medical Sciences; Islamic Azad University; Mashhad
   University of Medical Sciences; Birjand University of Medical Sciences;
   Birjand University of Medical Sciences; University of Sussex; University
   of Brighton; Mashhad University of Medical Sciences; Mashhad University
   of Medical Sciences; Mashhad University of Medical Sciences
RP Bahrami, A (corresponding author), Mashhad Univ Med Sci, Imam Reza Hosp, Fac Med, Clin Res Dev Unit, Mashhad 9137913316, Iran.
EM Afsbahramia931@gmail.com
RI Nakhaee, Samaneh/N-9039-2017; Mohamadifard, Mahtab/AAH-3843-2021;
   bahrami, afsaneh/Q-3369-2018
FU Birjand University of Medical Sciences, Birjand, Iran [456343]; 
   [456129]
FX <B>Funding</B> This study was supported by grants [grant nu# 456129
   (Afsane Bahrami) and 456343 (Khadijeh Farrokhfall) ] from Birjand
   University of Medical Sciences, Birjand, Iran.
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NR 80
TC 1
Z9 1
U1 2
U2 13
PU ELSEVIER GMBH
PI MUNICH
PA HACKERBRUCKE 6, 80335 MUNICH, GERMANY
SN 2210-8033
EI 2210-8041
J9 J HERB MED
JI J. Herb. Med.
PD SEP
PY 2023
VL 41
AR 100705
DI 10.1016/j.hermed.2023.100705
EA AUG 2023
PG 9
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA Q7RD9
UT WOS:001059450500001
DA 2025-06-11
ER

PT J
AU Waehler, R
AF Waehler, Reinhard
TI Fatty acids: facts vs. fiction
SO INTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCH
LA English
DT Review
DE saturated fatty acids; trans fatty acids and conjugated linoleic acid;
   omega 7 fatty acids; omega 3 and omega 6 fatty acids; omega-3 index;
   statins; fish oil quality and dosage
ID ALPHA-LINOLENIC ACID; LONG-CHAIN OMEGA-3-FATTY-ACIDS; CIRCULATING
   OXIDIZED LDL; FISH-OIL SUPPLEMENTATION; CORONARY-ARTERY-DISEASE;
   C-REACTIVE PROTEIN; METABOLIC SYNDROME; CARDIOVASCULAR-DISEASE;
   EICOSAPENTAENOIC ACID; OXIDATIVE STRESS
AB During the last 100 years official dietary guidelines have recommended an increased consumption of fats derived from seeds while decreasing the consumption of traditional fats, especially saturated fats. These recommendations are being challenged by recent studies. Furthermore, the increased use of refining processes in fat production had deleterious health effects. Today, the number of high-quality studies on fatty acids is large enough to make useful recommendations on clinical application and everyday practice. Saturated fats have many beneficial functions and palmitic acid appears to be problematic only when it is synthesized due to excess fructose consumption. Trans fatty acids were shown to be harmful when they are manmade but beneficial when of natural origin. Conjugated linoleic acid has many benefits but the isomer mix that is available in supplement form differs from its natural origin and may better be avoided. The omega 3 fatty acid linolenic acid has rather limited use as an anti-inflammatory agent - a fact that is frequently overlooked. On the other hand, the targeted use of long chain omega 3 fatty acids based on blood analysis has great potential to supplement or even be an alternative to various pharmacological therapies. At the same time omega 6 fatty acids like linoleic acid and arachidonic acid have important physiological functions and should not be avoided but their consumption needs to be balanced with long chain omega 3 fatty acids. The quality and quantity of these fats together with appropriate antioxidative protection are critical for their positive health effects.
C1 [Waehler, Reinhard] TISSO Nat Prod GmbH, Wenden, Germany.
RP Waehler, R (corresponding author), TISSO Nat Prod GmbH, Eisenstr 1, D-57482 Wenden, Germany.
EM dr.waehler@tisso.de
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NR 275
TC 7
Z9 7
U1 8
U2 44
PU IMR PRESS
PI ROBINSON
PA 112 ROBINSON RD, ROBINSON, SINGAPORE
SN 0300-9831
EI 1664-2821
J9 INT J VITAM NUTR RES
JI Int. J. Vitam. Nutr. Res.
PD JUN
PY 2023
VL 93
IS 3
BP 268
EP 288
DI 10.1024/0300-9831/a000713
PG 21
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA J2AO4
UT WOS:001007691000009
PM 34041926
OA Green Submitted, hybrid
DA 2025-06-11
ER

PT J
AU Kuzmenko, NV
   Tsyrlin, VA
   Pliss, MG
AF Kuzmenko, N. V.
   Tsyrlin, V. A.
   Pliss, M. G.
TI Meta-Analysis of Experimental Studies of Diet-Dependent Effects of
   Melatonin Monotherapy on Circulatory Levels of Triglycerides,
   Cholesterol, Glucose and Insulin in Rats
SO JOURNAL OF EVOLUTIONARY BIOCHEMISTRY AND PHYSIOLOGY
LA English
DT Review
DE melatonin; fructose; fats; insulin; triglycerides; cholesterol; glucose
ID INDUCED METABOLIC SYNDROME; SPRAGUE-DAWLEY RATS; BODY-WEIGHT GAIN;
   LIPID-PEROXIDATION; SERUM-CHOLESTEROL; THYROID-HORMONES; OXIDATIVE
   STRESS; RECEPTOR GPR50; SECRETION; SUPPLEMENTATION
AB Melatonin modulates diurnal and seasonal metabolic rhythms.However, the effects of long-term exogenous melatonin intake onthe parameters of lipid and carbohydrate metabolism in various dietsare still unclear. Here, we carried out a meta-analysis of 53 publicationsexploring the effect of melatonin monotherapy on lipid and carbohydratemetabolism in rats fed a standard diet (44 publications), as wellas diets enriched with fructose (7 publications), fats (11 publications),and cholesterol (5 publications). According to the literature, high-fructosediet caused a significant increase in triglyceride (TG), glucoseand insulin blood levels. High-fat diet induced an increase in TG,total cholesterol (TC) and insulin, as well as a decrease in high-densitylipoprotein (HDL) blood levels. In rats kept on a high-cholesteroldiet, an increase in TC and a decrease in HDL blood levels was observed.Melatonin therapy reduced TG, TC, and insulin levels but did notalter glucose levels in rats fed high-fructose and high-fat diets.With a high-cholesterol diet, melatonin (with no regard to its dose)decreased TC levels and increased HDL and glucose levels, but leftTG concentrations unchanged. Our meta-analysis revealed no beneficialeffect of increasing the melatonin dose against enriched diets.With a standard diet, long-term melatonin therapy also reduced insulinlevels, but had no effect on TC while increasing glucose concentrations.The deterioration in carbohydrate metabolism was associated withhigher melatonin doses at the onset of the therapy, as well as intraperitoneal,intragastric (though a gastric tube) or light-phase melatonin administration.In addition, high doses of melatonin were associated with the worsening oflipid metabolism in a standard diet. The effect of melatonin wasdirected toward minimizing diet-induced changes in the lipid profile,which confirms the homeostatic role of this hormone in lipid metabolism.
C1 [Kuzmenko, N. V.; Tsyrlin, V. A.; Pliss, M. G.] Almazov Natl Med Res Ctr, St Petersburg, Russia.
   [Kuzmenko, N. V.; Pliss, M. G.] Pavlov State Med Univ St Petersburg, St Petersburg, Russia.
C3 Almazov National Medical Research Centre; Pavlov First Saint Petersburg
   State Medical University
RP Kuzmenko, NV (corresponding author), Almazov Natl Med Res Ctr, St Petersburg, Russia.; Kuzmenko, NV (corresponding author), Pavlov State Med Univ St Petersburg, St Petersburg, Russia.
EM nat.kuzmencko2011@yandex.ru
RI pliss, mikhail/AAI-8991-2021
FU  [056-00119-22-00]
FX This work was state budget funded; state assignment no. 056-00119-22-00.
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NR 106
TC 3
Z9 4
U1 0
U2 7
PU PLEIADES PUBLISHING INC
PI NEW YORK
PA PLEIADES HOUSE, 7 W 54 ST, NEW YORK,  NY, UNITED STATES
SN 0022-0930
EI 1608-3202
J9 J EVOL BIOCHEM PHYS+
JI J. Evol. Biochem. Physiol.
PD JAN
PY 2023
VL 59
IS 1
BP 213
EP 231
DI 10.1134/S0022093023010180
PG 19
WC Biochemistry & Molecular Biology; Evolutionary Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Evolutionary Biology; Physiology
GA R0LT8
UT WOS:001061350100018
DA 2025-06-11
ER

PT J
AU Dong, J
   Zheng, HL
   Zeng, QY
   Zhang, X
   Du, L
   Bais, S
AF Dong, Jie
   Zheng, HaiLong
   Zeng, Qiuyao
   Zhang, Xian
   Du, Liang
   Bais, Souravh
TI Protective effect of D-(-)-quinic acid as food supplement in modulating
   AMP-activated protein kinase signalling pathway activation in HFD
   induced obesity
SO HUMAN & EXPERIMENTAL TOXICOLOGY
LA English
DT Article
DE D-(-)-Quinic acid; hepatoprotective; alpha-glucosidase; high fat diet
ID HIGH-FAT DIET; PANCREATIC LIPASE; METABOLIC SYNDROME; ALPHA-GLUCOSIDASE;
   OXIDATIVE STRESS; ACCUMULATION; INFLAMMATION; INCREASES; EXTRACTS;
   DISEASE
AB Background: Dietary quinic acid given as the nutritional supplement, which may leads to tryptophan and nicotinamide production in the intestinal tract and NAD+ precursor which can prevent from the negative consequences of high fat diet (HFD) consumption.
   Objective: The present study was designed to assess in vivo and in vitro effect of D-(-)-Quinic acid in high-fat diet induced hyperlipidemia in mice.
   Material and methods: Thirty six albino mice were randomly divided in six groups and each group had six mice. Group I, controlled mice given normal pellet diet, Group-II mice, administered with high fat diet (HFD), Group-III mice given standard drug, Atorvastatin (20 mg/kg, p.o.) along with HFD to mice and Group IV, V and VI mice received D-(-)-Quinic acid at a dose of 75, 150 and 300 mg/kg, respectively in separate group along with HFD to mice. After completion of trial (49 days) the animals were sacrificed and evaluated for body weight, organ fat pad weight, and changes in weight of liver, heart and kidney and also for biochemical parameters, expression of adipogenic and inflammation markers in adipose tissues, and histology examination of liver tissue.
   Results: In vitro testing results showed, D-(-)-Quinic acid potentially inhibit a-glucosidase enzyme activity as compared to acarbose. The D-(-)-Quinic acid showed significant hypolipidemic activity by decreasing the increased level of cholesterol, triglyceride level, LDL, VLDL and other hepatic parameters like SGOT and SGPT in serum. D-(-)-Quinic acid reduces the mRNA expression level of PPAR-gamma 2, TNF-alpha, IL-1 beta and IL-6 in adipose tissue in hyperlipidemic mice.
C1 [Dong, Jie] Guangzhou Twelfth Peoples Hosp, Dept Clin Lab, Guangzhou, Peoples R China.
   [Zheng, HaiLong] Hainan Med Univ, Dept Endocrinol, Affiliated Hosp 1, Haikou, Hainan, Peoples R China.
   [Zeng, Qiuyao] Sun Yat Sen Univ, Collaborat Innovat Ctr Canc Med, Dept Clin Lab Med, State Key Lab Oncol South China,Canc Ctr, Guangzhou, Peoples R China.
   [Zhang, Xian; Du, Liang] Hubei Univ Med, Sinopharm Dongfeng Gen Hosp, Dept Endocrinol & Metab, Shiyan 442008, Hubei, Peoples R China.
   [Bais, Souravh] Sage Univ, Inst Pharmaceut Sci, Indore, Madhya Pradesh, India.
C3 Hainan Medical University; State Key Lab Oncology South China; Sun Yat
   Sen University; Hubei University of Medicine
RP Du, L (corresponding author), Hubei Univ Med, Sinopharm Dongfeng Gen Hosp, Dept Endocrinol & Metab, Shiyan 442008, Hubei, Peoples R China.
EM duliangdf120@sina.com
RI Bais, Dr Souravh/D-1998-2013
OI Bais, Dr Souravh/0000-0002-6698-6912
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NR 41
TC 18
Z9 18
U1 1
U2 16
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0960-3271
EI 1477-0903
J9 HUM EXP TOXICOL
JI Hum. Exp. Toxicol.
PD AUG
PY 2022
VL 41
AR 09603271221119804
DI 10.1177/09603271221119804
PG 10
WC Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Toxicology
GA 4C9LU
UT WOS:000846765900001
PM 36006763
OA gold
DA 2025-06-11
ER

PT J
AU Yamasandhi, PG
   Dharmalingam, M
   Balekuduru, A
AF Yamasandhi, P. Ganavi
   Dharmalingam, Mala
   Balekuduru, A.
TI Fetuin-A in newly detected type 2 diabetes mellitus as a marker of
   non-alcoholic fatty liver disease
SO INDIAN JOURNAL OF GASTROENTEROLOGY
LA English
DT Article
DE Alpha 2 Heremans-Schmid glycoprotein (AHSG); Endoplasmic reticulum
   stress; Hepatokine; Inflammation; Insulin resistance; Intrahepatic fat
   accumulation; Metabolic syndrome; Transient elastography
ID SERUM FETUIN; DIAGNOSIS
AB Introduction Fetuin-A has been implicated in the causation of metabolic disorders such as obesity, diabetes, and hepatic steatosis. Numerous studies have shown the association between levels of fetuin-A in type 2 diabetes mellitus (T2DM) and non-alcoholic fatty liver disease (NAFLD). The levels of fetuin-A in newly detected type 2 diabetic (NDD) patients and its relationship with the presence of NAFLD have not been studied. Objective To study the fetuin-A levels in patients with NDD and its relationship with NAFLD. Methods A total of 60 NDD patients were studied. The diagnosis of NAFLD was made on the basis of transient elastography. Serum fetuin-A and serum fasting insulin were measured along with other investigations. Results The percentage of patients with NAFLD in NDD was 53.33%. Fetuin-A levels were significantly higher in NDD with NAFLD compared to those without NAFLD. There was no association of fetuin-A with age, systolic and diastolic blood pressure, fasting blood sugar (FBS), hemoglobin (Hb)A1c, fasting insulin, homeostatic model assessment-insulin resistance (HOMA-IR), quantitative insulin sensitivity check index (QUICKI), and markers of advanced fibrosis. Fetuin-A levels beyond 1166.5 mcg/mL could predict the development of NAFLD with odds ratio (OR) of 4.33 (95% CI: 1.364-13.77), which remained significant after adjustment for various confounding factors. Conclusion Fetuin-A is a reliable marker of NAFLD in NDD and is positively associated with insulin resistance (IR). The observation in this study suggests that high serum fetuin-A levels in patients with NAFLD do not merely reflect the effects of insulin resistance, but also a more extensive distortion of liver architecture.
C1 [Yamasandhi, P. Ganavi; Dharmalingam, Mala] Ramaiah Med Coll, Dept Endocrinol, MSRIT Post, Bangalore 560054, Karnataka, India.
   [Balekuduru, A.] Ramaiah Med Coll, Dept Gastroenterol, MSRIT Post, Bangalore 560054, Karnataka, India.
RP Yamasandhi, PG (corresponding author), Ramaiah Med Coll, Dept Endocrinol, MSRIT Post, Bangalore 560054, Karnataka, India.
EM ganavipattabhi@gmail.com
FU Endocrine Society of India
FX The present study was supported by the Endocrine Society of India.
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NR 21
TC 11
Z9 12
U1 0
U2 2
PU SPRINGER INDIA
PI NEW DELHI
PA 7TH FLOOR, VIJAYA BUILDING, 17, BARAKHAMBA ROAD, NEW DELHI, 110 001,
   INDIA
SN 0254-8860
EI 0975-0711
J9 INDIAN J GASTROENTER
JI Indian J. Gastroenterol.
PD DEC
PY 2021
VL 40
IS 6
BP 556
EP 562
DI 10.1007/s12664-021-01176-6
EA DEC 2021
PG 7
WC Gastroenterology & Hepatology
WE Emerging Sources Citation Index (ESCI)
SC Gastroenterology & Hepatology
GA YQ8FW
UT WOS:000734151600001
PM 34950996
DA 2025-06-11
ER

PT J
AU Suriagandhi, V
   Nachiappan, V
AF Suriagandhi, Vennila
   Nachiappan, Vasanthi
TI Protective Effects of Melatonin against Obesity-Induced by Leptin
   Resistance
SO BEHAVIOURAL BRAIN RESEARCH
LA English
DT Review
DE Leptin resistance; Obesity; Melatonin; Sleep disturbance; Circadian
   rhythm; Adipose tissue
ID WHITE ADIPOSE-TISSUE; PLASMA LEPTIN; BODY-WEIGHT; CIRCADIAN-RHYTHMS;
   FOOD-INTAKE; PINEALECTOMY INCREASES; METABOLIC SYNDROME; RECEPTOR;
   INSULIN; GLUCOSE
AB Consumption of an exceedingly high-fat diet with irregular eating and sleeping habits is typical in the current sedentary lifestyle, leading to chronic diseases like obesity and diabetes mellitus. Leptin is a primary appetiteregulating hormone that binds to its receptors in the hypothalamic cell membrane and regulates downstream appetite-regulating neurons NPY/AgRp and POMC in the hypothalamus. Based on the fat content of the adipose tissue, leptin is secreted, and excess accumulation of fat in adipose tissue stimulates the abnormal secretion of leptin. The secreted leptin circulating in the bloodstream uses its transporters to cross the blood-brain barrier (BBB) and reach the CSF. There is a saturation limit for leptin bound to its transporters to cross the BBB, and increased leptin secretion in adipose tissue has a defect in its transport across the BBB. Leptin resistance is due to excess leptin, a saturation of its transporters, and deficiency in either the receptor level or signalling in the hypothalamus. Leptin resistance leads to obesity due to excess food intake and less energy expenditure. Normal leptin secretion follows a rhythm, and alteration in the lifestyle leads to hormonal imbalances and increases ROS generation leading to oxidative stress. The sleep disturbance causes obesity with increased lipid accumulation in adipose tissue. Melatonin is the master regulator of the sleep-wake cycle secreted by the pineal gland during the night. It is a potent antioxidant with anti-inflammatory properties. Melatonin is secreted in a pattern called the circadian rhythm in humans as well. Research indicates that melatonin plays a vital role in hormonal regulation and energy metabolism, including leptin signalling and secretion. Studying the role of melatonin in leptin regulation will help us combat the pathologies of obesity caused by leptin resistance.
C1 [Suriagandhi, Vennila; Nachiappan, Vasanthi] Bharathidasan Univ, Biomembrane Lab, Dept Biochem, Sch Life Sci, Tiruchirappalli 620024, India.
C3 Bharathidasan University
RP Nachiappan, V (corresponding author), Bharathidasan Univ, Biomembrane Lab, Dept Biochem, Sch Life Sci, Tiruchirappalli 620024, India.
EM vasanthibch@gmail.com
OI Suriyagandhi, Vennila/0009-0001-7762-241X
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NR 133
TC 27
Z9 30
U1 1
U2 27
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0166-4328
EI 1872-7549
J9 BEHAV BRAIN RES
JI Behav. Brain Res.
PD JAN 24
PY 2022
VL 417
AR 113598
DI 10.1016/j.bbr.2021.113598
EA OCT 2021
PG 9
WC Behavioral Sciences; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Behavioral Sciences; Neurosciences & Neurology
GA WM0KV
UT WOS:000710785100006
PM 34563600
DA 2025-06-11
ER

PT J
AU Schaffert, A
   Krieg, L
   Weiner, J
   Schlichting, R
   Ueberham, E
   Karkossa, I
   Bauer, M
   Landgraf, K
   Junge, KM
   Wabitsch, M
   Lehmann, J
   Escher, BI
   Zenclussen, AC
   Körner, A
   Blüher, M
   Heiker, JT
   von Bergen, M
   Schubert, K
AF Schaffert, Alexandra
   Krieg, Laura
   Weiner, Juliane
   Schlichting, Rita
   Ueberham, Elke
   Karkossa, Isabel
   Bauer, Mario
   Landgraf, Kathrin
   Junge, Kristin M.
   Wabitsch, Martin
   Lehmann, Joerg
   Escher, Beate I.
   Zenclussen, Ana C.
   Koerner, Antje
   Blueher, Matthias
   Heiker, John T.
   von Bergen, Martin
   Schubert, Kristin
TI Alternatives for the worse: Molecular insights into adverse effects of
   bisphenol a and substitutes during human adipocyte differentiation
SO ENVIRONMENT INTERNATIONAL
LA English
DT Article
DE Peroxisome proliferator-activated receptor gamma; (PPAR gamma);
   Bisphenol A (BPA); Endocrine disruption; Obesogene; SGBS; Proteomics
ID ADIPOSE-TISSUE; PPAR-GAMMA; OXIDATIVE STRESS; IN-VITRO; ADIPOGENIC
   DIFFERENTIATION; IMPAIRED ADIPOGENESIS; GLUCOSE-HOMEOSTASIS; INSULIN
   SENSITIVITY; PERINATAL EXPOSURE; ADIPONECTIN
AB Bisphenol A (BPA), which is used in a variety of consumer-related plastic products, was reported to cause adverse effects, including disruption of adipocyte differentiation, interference with obesity mechanisms, and impairment of insulin- and glucose homeostasis. Substitute compounds are increasingly emerging but are not sufficiently investigated. We aimed to investigate the mode of action of BPA and four of its substitutes during the differentiation of human preadipocytes to adipocytes and their molecular interaction with peroxisome proliferatoractivated receptor gamma (PPAR gamma), a pivotal regulator of adipogenesis. Binding and effective biological activation of PPAR gamma were investigated by surface plasmon resonance and reporter gene assay, respectively. Human preadipocytes were continuously exposed to BPA, BPS, BPB, BPF, BPAF, and the PPAR gamma-antagonist GW9662. After 12 days of differentiation, lipid production was quantified via Oil Red O staining, and global protein profiles were assessed using LC-MS/MS-based proteomics. All tested bisphenols bound to human PPAR gamma with similar efficacy as the natural ligand 15d-PGJ2 in vitro and provoked an antagonistic effect on PPAR gamma in the reporter gene assay at non-cytotoxic concentrations. During the differentiation of human preadipocytes, all bisphenols decreased lipid production. Global proteomics displayed a down-regulation of adipogenesis and metabolic pathways, similar to GW9662. Interestingly, pro-inflammatory pathways were up-regulated, MCP1 release was increased, and adiponectin decreased. pAKT/AKT ratios revealed significantly reduced insulin sensitivity by BPA, BPB, and BPS upon insulin stimulation. Thus, our results show that not only BPA but also its substitutes disrupt crucial metabolic functions and insulin signaling in adipocytes under low, environmentally relevant concentrations. This effect, mediated through inhibition of PPAR gamma, may promote hypertrophy of adipose tissue and increase the risk of developing metabolic syndrome, including insulin resistance.
C1 [Schaffert, Alexandra; Krieg, Laura; Karkossa, Isabel; von Bergen, Martin; Schubert, Kristin] UFZ Helmholtz Ctr Environm Res, Dept Mol Syst Biol, Permoserstr 15, D-04318 Leipzig, Germany.
   [Weiner, Juliane; Blueher, Matthias; Heiker, John T.] Helmholtz Inst Metab Obes & Vasc Res HI MAG, Leipzig, Germany.
   [Weiner, Juliane; Blueher, Matthias] Univ Hosp Leipzig, Dept Endocrinol, Nephrol Rheumatol, Med Res Ctr, Leipzig, Germany.
   [Schlichting, Rita; Escher, Beate I.] UFZ Helmholtz Ctr Environm Res, Dept Cell Toxicol, Leipzig, Germany.
   [Ueberham, Elke; Lehmann, Joerg] Fraunhofer Inst Cell Therapy & Immunol, Dept Therapy Validat, Leipzig, Germany.
   [Bauer, Mario; Junge, Kristin M.; Zenclussen, Ana C.] UFZ Helmholtz Ctr Environm Res, Dept Environm Immunol, Leipzig, Germany.
   [Landgraf, Kathrin; Koerner, Antje] Univ Leipzig, Hosp Children & Adolescents, Ctr Pediat Res, Leipzig, Germany.
   [Wabitsch, Martin] Ulm Univ, Div Pediat Endocrinol & Diabet, Med Ctr, Ulm, Germany.
   [Escher, Beate I.] Eberhard Karls Univ Tubingen, Ctr Appl Geosci, Environm Toxicol, Tubingen, Germany.
   [von Bergen, Martin] Univ Leipzig, Inst Biochem, Leipzig, Germany.
C3 Helmholtz Association; Helmholtz Center for Environmental Research
   (UFZ); Leipzig University; Helmholtz Association; Helmholtz Center for
   Environmental Research (UFZ); Fraunhofer Gesellschaft; Fraunhofer
   Germany; Fraunhofer Cell Therapy & Immunology; Helmholtz Association;
   Helmholtz Center for Environmental Research (UFZ); Leipzig University;
   Ulm University; Eberhard Karls University of Tubingen; Leipzig
   University
RP Schubert, K (corresponding author), UFZ Helmholtz Ctr Environm Res, Dept Mol Syst Biol, Permoserstr 15, D-04318 Leipzig, Germany.
EM kristin.schubert@ufz.de
RI Schubert, Kristin/AAB-6438-2020; Zenclussen, Ana/AAE-8760-2020;
   Schlichting, Rita/JRX-4227-2023; Bauer, Mario/AAZ-7540-2021; Landgraf,
   Kathrin/J-4937-2016; Escher, Beate/ABE-8070-2020; Junge,
   Kristin/L-2630-2019; Karkossa, Isabel/AAH-1809-2021; Heiker,
   John/O-9728-2019; Lehmann, Joerg/AAV-3264-2020; Korner,
   Antje/B-3988-2015; Zenclussen, Ana Claudia/G-2186-2013; von Bergen,
   Martin/D-7960-2011
OI Korner, Antje/0000-0001-6001-0356; Junge, Kristin/0000-0001-5016-110X;
   Zenclussen, Ana Claudia/0000-0003-3544-4552; Weiner,
   Juliane/0000-0003-1055-6005; Landgraf, Kathrin/0000-0002-6878-6033;
   Heiker, John/0000-0003-2822-3006; Schaffert,
   Alexandra/0000-0001-8159-1292; Lehmann, Jorg/0000-0001-8560-648X; von
   Bergen, Martin/0000-0003-2732-2977
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NR 93
TC 34
Z9 34
U1 2
U2 49
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0160-4120
EI 1873-6750
J9 ENVIRON INT
JI Environ. Int.
PD NOV
PY 2021
VL 156
AR 106730
DI 10.1016/j.envint.2021.106730
EA JUN 2021
PG 16
WC Environmental Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology
GA UB1ZL
UT WOS:000685649300013
PM 34186270
OA gold
DA 2025-06-11
ER

PT J
AU Zhou, J
   Wei, YP
   Lan, Y
   Zuo, JJ
   Hou, XQ
   Hou, WK
AF Zhou, Jian
   Wei, Yaping
   Lan, Yuan
   Zuo, Jingjing
   Hou, Xiangqing
   Hou, Weikai
TI Individual and joint association of bioavailable testosterone and aging
   with neutrophil-to-lymphocyte ratio in Chinese middle-aged and elderly
   men
SO AGING CLINICAL AND EXPERIMENTAL RESEARCH
LA English
DT Article
DE Chronic systematic inflammation; Neutrophil-to-lymphocyte ratio;
   Bioavailable testosterone; Aging
ID SYSTEMIC INFLAMMATION; CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME;
   OXIDATIVE STRESS; RISK; ATHEROSCLEROSIS; REPLACEMENT; PERSPECTIVE;
   EXPRESSION; PREDICTION
AB Background and objectives Accumulating evidences suggest that chronic systemic inflammation (CSI) is independently associated with large number of major non-communicable chronic diseases (NCDs) ranging from metabolic disorders to cancers, and neutrophil-to-lymphocyte ratio (NLR) has been accepted as a novel, convenient marker for CSI response. Testosterone deficiency in men is linked to high risk of NCDs. This cross-sectional study aimed to investigate the individual and joint association of bioavailable testosterone (BIOT) and aging with NLR. Methods A total of 132 male adults were enrolled during Jan. 2011 and Oct. 2017 in the first affiliated hospital of University of Science and Technology of China. Local weighted regression (LOESS) and multivariable generalized linear regression models were utilized to comprehensively examine the individual and joint association between BIOT and age with NLR. Results Obvious linear relationships between NLR and BIOT or age were observed with the LOESS models. NLR was negatively correlated to BIOT after adjusting for some potential confounding factors (P = 0.034). As compared to the lowest quartile of BIOT, the adjusted decrease of NLR for the 2nd, 3rd and 4th quartiles were 0.40, 0.64 and 0.72, respectively. Meanwhile, NLR was observed to be independently correlated to elevated age (P = 0.043). Furthermore, as compared to the counterparts, men over 70 years combined with plasma BIOT less than 4.7 nmol/L had the highest NLR level, which suggested that low BIOT and aging jointly correlated to the level of NLR (P = 0.005). Conclusion BIOT deficiency and aging were individually and jointly correlated to CSI. Men over 70 years combined with BIOT < 4.7 nmol/L were more like to have higher grade of CSI than others.
C1 [Zhou, Jian; Hou, Weikai] Shandong Univ, Qilu Hosp, Dept Endocrinol, Jinan 250012, Shandong, Peoples R China.
   [Zhou, Jian; Hou, Weikai] Shandong Univ, Inst Endocrinol & Metab, Jinan 250012, Shandong, Peoples R China.
   [Zhou, Jian; Hou, Weikai] Key Lab Endocrinol & Metab Shandong Prov Med & Hl, 107 West Culture Rd, Jinan 250012, Shandong, Peoples R China.
   [Zhou, Jian] Univ Sci & Technol China, Div Life Sci & Med, Affiliated Hosp 1, Dept Geriatr, Hefei 230001, Anhui, Peoples R China.
   [Wei, Yaping; Hou, Xiangqing] Wenzhou Med Univ, Sch Publ Hlth & Management, Dept Prevent Med, Wenzhou 325035, Zhejiang, Peoples R China.
   [Lan, Yuan; Zuo, Jingjing] Wenzhou Med Univ, Sch Ophthalmol & Optometry, Wenzhou 325000, Zhejiang, Peoples R China.
C3 Shandong University; Shandong University; Chinese Academy of Sciences;
   University of Science & Technology of China, CAS; Wenzhou Medical
   University; Wenzhou Medical University
RP Hou, WK (corresponding author), Shandong Univ, Qilu Hosp, Dept Endocrinol, Jinan 250012, Shandong, Peoples R China.; Hou, WK (corresponding author), Shandong Univ, Inst Endocrinol & Metab, Jinan 250012, Shandong, Peoples R China.; Hou, WK (corresponding author), Key Lab Endocrinol & Metab Shandong Prov Med & Hl, 107 West Culture Rd, Jinan 250012, Shandong, Peoples R China.
EM wkhou_qilu@126.com
RI Zuo, Jingjing/HPD-0763-2023; jianming, zhou/GZN-0687-2022
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NR 44
TC 9
Z9 9
U1 0
U2 5
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1594-0667
EI 1720-8319
J9 AGING CLIN EXP RES
JI Aging Clin. Exp. Res.
PD AUG
PY 2020
VL 32
IS 8
BP 1515
EP 1523
DI 10.1007/s40520-019-01333-0
PG 9
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA NF2JG
UT WOS:000563125700013
PM 31515688
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Wu, XW
   Huang, J
   Shen, C
   Liu, YL
   He, SJ
   Sun, JQ
   Yu, BL
AF Wu, Xunwei
   Huang, Jun
   Shen, Cong
   Liu, Yeling
   He, Shengjie
   Sun, Junquan
   Yu, Bolan
TI NRF2 deficiency increases obesity susceptibility in a mouse menopausal
   model
SO PLOS ONE
LA English
DT Article
ID INSULIN-RESISTANCE; METABOLIC SYNDROME; SEROTONIN; PATHWAY; OVARIAN;
   MASS
AB The risk of metabolic abnormalities in menopausal women increases significantly due to the decline in estrogen level. Nuclear factor E2-related factor 2 (NRF2) is an important oxidative stress sensor that plays regulatory role in energy metabolism. Therefore, an ovariectomized menopausal model in Nrf2-knockout (KO) mice was applied to evaluate the effect of Nrf2 deficiency on metabolism in menopausal females. The mice were divided into four groups according to their genotypes and treatments. Blood samples and bodyweights were obtained preoperatively and in the first to ninth postoperative weeks after overnight fasting. Serum levels of triglycerides (TG), total cholesterol (T-CHO), low-density lipoprotein (LDL), high-density lipoprotein (HDL), and glucose (GLU) were measured at postoperative weeks 0, 1, 3, 5, 7, and 9. Neurotransmitter dopamine (DA) and serotonin (5-HT) was analyzed in brain tissues after sacrifice at postoperative week 9. The results demonstrated that, compared with the corresponding wild-type (WT) mice, KO ovariectomized mice had a greater bodyweight gain (P<0.01). Serum analysis showed that the serum GLU, T-CHO, and TG were significantly lower (P<0.05) but LDL was significantly higher (P<0.05) in the KO control mice than that in WT control mice. However, different from the WT counterparts, an increase in blood GLU level (P<0.05), unchanged T-CHO, TG, and HDL levels, and a significant reduction in LDL (P<0.01) was found in the KO ovariectomized mice. In addition, the level of 5-HT was significantly reduced (P<0.05) in the KO mice after ovariectomy. In conclusion, the combination of Nrf2 deletion and a decline in estrogen level induced a significant increase in bodyweight, which may be associated with their altered glucose and LDL metabolism and decreased 5-HT levels. From a clinical perspective, women with antioxidant defense deficiency may have an increased risk of metabolic abnormalities after menopause.
C1 [Wu, Xunwei; Yu, Bolan] Guangzhou Med Univ, Key Lab Major Obstet Dis Guangdong Prov, Affiliated Hosp 3, Guangzhou, Peoples R China.
   [Wu, Xunwei; Yu, Bolan] Guangzhou Med Univ, Guangdong Engn & Technol Res Ctr Maternal Fetal M, Affiliated Hosp 3, Guangzhou, Peoples R China.
   [Huang, Jun] Guangzhou Med Univ, Dept Obstet, Affiliated Hosp 3, Guangzhou, Peoples R China.
   [Shen, Cong; Liu, Yeling; He, Shengjie; Sun, Junquan] Guangzhou Med Univ, Clin Coll 3, Guangzhou, Peoples R China.
C3 Guangzhou Medical University; Guangzhou Medical University; Guangzhou
   Medical University; Guangzhou Medical University
RP Yu, BL (corresponding author), Guangzhou Med Univ, Key Lab Major Obstet Dis Guangdong Prov, Affiliated Hosp 3, Guangzhou, Peoples R China.; Yu, BL (corresponding author), Guangzhou Med Univ, Guangdong Engn & Technol Res Ctr Maternal Fetal M, Affiliated Hosp 3, Guangzhou, Peoples R China.
EM yubolan-q@qq.com
RI Huang, Jun/J-7002-2015
FU Key Project of Guangzhou Science and Technology Innovation Committee
   [201804020057]; Guangdong Science and Technology Department Project
   [2019B030316023]
FX This study was supported by the Key Project of Guangzhou Science and
   Technology Innovation Committee (grant number 201804020057), Guangdong
   Science and Technology Department Project (grant number 2019B030316023),
   and Lin He's Academician Workstation of New Medicine and Clinical
   Translation at the Third Affiliated Hospital. BY received all the
   funding. The funders had no role in study design, data collection and
   analysis, decision to publish, or preparation of the manuscript.
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NR 36
TC 8
Z9 8
U1 0
U2 2
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD FEB 11
PY 2020
VL 15
IS 2
AR e0228559
DI 10.1371/journal.pone.0228559
PG 14
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA LP9KA
UT WOS:000534633200020
PM 32045430
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Krstic, J
   Galhuber, M
   Schulz, TJ
   Schupp, M
   Prokesch, A
AF Krstic, Jelena
   Galhuber, Markus
   Schulz, Tim J.
   Schupp, Michael
   Prokesch, Andreas
TI p53 as a Dichotomous Regulator of Liver Disease: The Dose Makes the
   Medicine
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE p53; liver disease; insulin resistance; non-alcoholic fatty liver
   disease; non-alcoholic steatohepatitis; hepatocellular carcinoma; liver
   regeneration; mouse models
ID INFLAMMATION-ASSOCIATED HEPATOCARCINOGENESIS; HEPATIC PROGENITOR CELLS;
   TUMOR-SUPPRESSOR P53; FATTY LIVER; HEPATOCELLULAR-CARCINOMA;
   NONALCOHOLIC STEATOHEPATITIS; INSULIN-RESISTANCE; MOUSE MODEL;
   MOLECULAR-MECHANISMS; DIRECT ACTIVATION
AB Lifestyle-related disorders, such as the metabolic syndrome, have become a primary risk factor for the development of liver pathologies that can progress from hepatic steatosis, hepatic insulin resistance, steatohepatitis, fibrosis and cirrhosis, to the most severe condition of hepatocellular carcinoma (HCC). While the prevalence of liver pathologies is steadily increasing in modern societies, there are currently no approved drugs other than chemotherapeutic intervention in late stage HCC. Hence, there is a pressing need to identify and investigate causative molecular pathways that can yield new therapeutic avenues. The transcription factor p53 is well established as a tumor suppressor and has recently been described as a central metabolic player both in physiological and pathological settings. Given that liver is a dynamic tissue with direct exposition to ingested nutrients, hepatic p53, by integrating cellular stress response, metabolism and cell cycle regulation, has emerged as an important regulator of liver homeostasis and dysfunction. The underlying evidence is reviewed herein, with a focus on clinical data and animal studies that highlight a direct influence of p53 activity on different stages of liver diseases. Based on current literature showing that activation of p53 signaling can either attenuate or fuel liver disease, we herein discuss the hypothesis that, while hyper-activation or loss of function can cause disease, moderate induction of hepatic p53 within physiological margins could be beneficial in the prevention and treatment of liver pathologies. Hence, stimuli that lead to a moderate and temporary p53 activation could present new therapeutic approaches through several entry points in the cascade from hepatic steatosis to HCC.
C1 [Krstic, Jelena; Galhuber, Markus; Prokesch, Andreas] Med Univ Graz, Gottfried Schatz Res Ctr Cell Signaling Metab & A, A-8010 Graz, Austria.
   [Schulz, Tim J.] German Inst Human Nutr, Dept Adipocyte Dev & Nutr, D-14558 Potsdam, Nuthetal, Germany.
   [Schulz, Tim J.] German Ctr Diabet Res DZD, D-85764 Munich, Germany.
   [Schulz, Tim J.] Univ Potsdam, Inst Nutr Sci, D-14558 Nuthetal, Germany.
   [Schupp, Michael] Humboldt Univ, Charite Univ Med Berlin, Freie Univ Berlin, D-10117 Berlin, Germany.
   [Schupp, Michael] Berlin Inst Hlth, Inst Pharmacol, Ctr Cardiovasc Res, D-10117 Berlin, Germany.
   [Prokesch, Andreas] BioTechMed Graz, A-8010 Graz, Austria.
C3 Medical University of Graz; Leibniz Association; Deutsches Institut fur
   Ernahrungsforschung Potsdam-Rehbrucke (DIfE); German Center for Diabetes
   Research (DZD); University of Potsdam; Berlin Institute of Health; Free
   University of Berlin; Humboldt University of Berlin; Charite
   Universitatsmedizin Berlin; Berlin Institute of Health
RP Prokesch, A (corresponding author), Med Univ Graz, Gottfried Schatz Res Ctr Cell Signaling Metab & A, A-8010 Graz, Austria.; Prokesch, A (corresponding author), BioTechMed Graz, A-8010 Graz, Austria.
EM jelena.krstic@medunigraz.at; markus.galhuber@medunigraz.at;
   tim.schulz@dife.de; michael.schupp@charite.de;
   andreas.prokesch@medunigraz.at
RI Schulz, Tim/F-4842-2013; Krstic, Jelena/L-3743-2016; PROKESCH,
   ANDREAS/B-6786-2019
OI Schulz, Tim/0000-0002-8413-3972; Krstic, Jelena/0000-0002-3423-533X;
   Schupp, Michael/0000-0003-3720-1052; PROKESCH,
   ANDREAS/0000-0002-8487-7103
FU Austrian Science Fund (FWF) [P29328, I3165]; MEFO grant from the Medical
   University of Graz; European Research Council [ERC-StG 311082]; German
   Research Foundation (DFG) [SCHU 2445/2-1, SCHU 2445/5-1, SCHU 2546/4-1];
   German Ministry of Education and Research (BMBF); State of Brandenburg
   (DZD Grant) [82DZD00302]; Austrian Science Fund (FWF) [I3165, P29328]
   Funding Source: Austrian Science Fund (FWF)
FX Andreas Prokesch and Jelena Krstic were supported by the Austrian
   Science Fund (FWF, Grant P29328). Andreas Prokesch and Markus Galhuber
   were supported by the Austrian Science Fund (FWF, Grant I3165). Andreas
   Prokesch was supported by MEFO grant from the Medical University of
   Graz. Tim J. Schulz was supported by the European Research Council
   (ERC-StG 311082), grants from the German Research Foundation (DFG; Grant
   IDs SCHU 2445/2-1 and SCHU 2445/5-1), the German Ministry of Education
   and Research (BMBF) and the State of Brandenburg (DZD Grant 82DZD00302).
   Michael Schupp was supported by the German Research Foundation (DFG,
   grant SCHU 2546/4-1).
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NR 161
TC 46
Z9 46
U1 0
U2 10
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD MAR
PY 2018
VL 19
IS 3
AR 921
DI 10.3390/ijms19030921
PG 23
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA GA4OO
UT WOS:000428309800278
PM 29558460
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Lamacchia, O
   Fontana, A
   Pacilli, A
   Copetti, M
   Fariello, S
   Garofolo, M
   Penno, G
   Trischitta, V
   De Cosmo, S
   Cignarelli, M
AF Lamacchia, Olga
   Fontana, Andrea
   Pacilli, Antonio
   Copetti, Massimiliano
   Fariello, Stefania
   Garofolo, Monia
   Penno, Giuseppe
   Trischitta, Vincenzo
   De Cosmo, Salvatore
   Cignarelli, Mauro
TI On the non-linear association between serum uric acid levels and
   all-cause mortality rate in patients with type 2 diabetes mellitus
SO ATHEROSCLEROSIS
LA English
DT Article
DE Diabetic complications; Oxidative stress; Risk factors
ID CARDIOVASCULAR-DISEASE MORTALITY; MARGINAL STRUCTURAL MODELS; METABOLIC
   SYNDROME; CAROTID ATHEROSCLEROSIS; INDEPENDENT PREDICTOR;
   CELL-PROLIFERATION; KIDNEY-DISEASE; FOLLOW-UP; RISK; POPULATION
AB Background and aims: High levels of serum uric acid (SUA) are associated with increased mortality risk in the general population. Contrasting results are available in people with diabetes. The aim of our study was to investigate the association and its functional form between SUA and all cause-mortality in patients with type 2 diabetes mellitus (T2DM).
   Methods: We studied three cohorts of patients with T2DM: Gargano Mortality Study, Foggia Mortality Study, Pisa Mortality Study. All-cause mortality rate was the end point of this study.
   Results: The most reliable relationship between SUA levels and all-cause mortality rate was quadratic, with such model being well approximated by SUA tertiles. Both tertiles 1 and 3 were at higher risk of mortality as compared to tertile 2: Hazard Ratio (HR) [95% Confidence Interval (CI)] = 1.34 (1.07-1.68) and 1.61 (1.29-1.99), respectively. In the pseudo-sample, created from the real pooled sample, the best relationship between SUA and all-cause mortality rate was quadratic. In a tree-based Recursive Partitioning and Regression Tree analysis two subgroups at increased risk of mortality were identified, namely those with SUA levels >= 7.28 mg/dl and with SUA levels <4.16 mg/dl as compared to patients with intermediate SUA levels (i.e. 4.16-7.28), thus providing further evidence on the J-shaped relationship between SUA levels and mortality rate.
   Conclusions: SUA was not linearly associated with all-cause mortality rate in patients with T2DM. For clinical and public health purposes such association is J-shaped. (C) 2017 Published by Elsevier Ireland Ltd.
C1 [Lamacchia, Olga; Fariello, Stefania; Cignarelli, Mauro] Univ Foggia, Dept Med & Surg Sci, Unit Endocrinol & Diabetol, Via Luigi Pinto, I-71122 Foggia, Italy.
   [Fontana, Andrea; Copetti, Massimiliano] IRCCS Casa Sollievo Sofferenza, Biostat Unit, Viale Padre Pio, I-71013 San Giovanni Rotondo, Italy.
   [Pacilli, Antonio; De Cosmo, Salvatore] IRCCS Casa Sollievo Sofferenza, Dept Med Sci, Unit Internal Med, Viale Padre Pio, I-71013 San Giovanni Rotondo, Italy.
   [Garofolo, Monia; Penno, Giuseppe] Univ Pisa, Dept Clin & Expt Med, Pisa, Italy.
   [Trischitta, Vincenzo] IRCCS Casa Sollievo Sofferenza, Res Unit Diabet & Endocrine Dis, San Giovanni Rotondo, Italy.
   [Trischitta, Vincenzo] IRCCS Casa Sollievo Sofferenza, Mendel Lab, San Giovanni Rotondo, Italy.
   [Trischitta, Vincenzo] Sapienza Univ Rome, Dept Expt Med, Rome, Italy.
C3 University of Foggia; IRCCS Casa Sollievo Della Sofferenza; IRCCS Casa
   Sollievo Della Sofferenza; University of Pisa; IRCCS Casa Sollievo Della
   Sofferenza; IRCCS Casa Sollievo Della Sofferenza; Istituto CSS Mendel;
   Sapienza University Rome
RP Cignarelli, M (corresponding author), Univ Foggia, Dept Med & Surg Sci, Unit Endocrinol & Diabetol, Via Luigi Pinto, I-71122 Foggia, Italy.; Copetti, M (corresponding author), IRCCS Casa Sollievo Sofferenza, Biostat Unit, Viale Padre Pio, I-71013 San Giovanni Rotondo, Italy.; De Cosmo, S (corresponding author), IRCCS Casa Sollievo Sofferenza, Dept Med Sci, Unit Internal Med, Viale Padre Pio, I-71013 San Giovanni Rotondo, Italy.
EM m.copetti@operapadrepio.it; s.decosmo@operapadrepio.it;
   mauro.cignarelli@unifg.it
RI COPETTI, MASSIMILIANO/AAG-1473-2021; COPETTI, MASSIMILIANO/K-3186-2016;
   Lamacchia, Olga/AEY-9588-2022; Garofolo, Monia/J-7530-2018; De Cosmo,
   Salvatore/J-7420-2016; Fontana, Andrea/J-8584-2016; TRISCHITTA,
   Vincenzo/K-1487-2016
OI COPETTI, MASSIMILIANO/0000-0002-7960-5947; Lamacchia,
   Olga/0000-0002-9175-489X; Garofolo, Monia/0000-0002-2518-3187; De Cosmo,
   Salvatore/0000-0001-8787-8286; Fontana, Andrea/0000-0002-6660-5315;
   TRISCHITTA, Vincenzo/0000-0003-1174-127X
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NR 51
TC 23
Z9 24
U1 0
U2 5
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0021-9150
EI 1879-1484
J9 ATHEROSCLEROSIS
JI Atherosclerosis
PD MAY
PY 2017
VL 260
BP 20
EP 26
DI 10.1016/j.atherosclerosis.2017.03.008
PG 7
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA ET6LT
UT WOS:000400403900004
PM 28334637
DA 2025-06-11
ER

PT J
AU Brüll, V
   Burak, C
   Stoffel-Wagner, B
   Wolffram, S
   Nickenig, G
   Müller, C
   Langguth, P
   Alteheld, B
   Fimmers, R
   Stehle, P
   Egert, S
AF Bruell, Verena
   Burak, Constanze
   Stoffel-Wagner, Birgit
   Wolffram, Siegfried
   Nickenig, Georg
   Mueller, Cornelius
   Langguth, Peter
   Alteheld, Birgit
   Fimmers, Rolf
   Stehle, Peter
   Egert, Sarah
TI Acute intake of quercetin from onion skin extract does not influence
   postprandial blood pressure and endothelial function in
   overweight-to-obese adults with hypertension: a randomized,
   double-blind, placebo-controlled, crossover trial
SO EUROPEAN JOURNAL OF NUTRITION
LA English
DT Article
DE Quercetin; Blood pressure; Postprandial metabolism; Cardiovascular
   diseases; Endothelial function
ID OXIDATIVE STRESS; NITRIC-OXIDE; PERIPHERAL VASODILATION; MORNING
   ATTENUATION; ANTIOXIDANT STATUS; METABOLIC SYNDROME; LIPEMIA; RISK;
   DYSFUNCTION; DIETARY
AB Purpose To determine whether postprandial metabolic and vascular responses induced by a high-fat and high-carbohydrate meal are attenuated by ingestion of the flavonol quercetin.
   Methods Twenty-two overweight-to-obese hypertensive patients participated in a randomized, double-blind, controlled, crossover meal study. They consumed a test meal (challenge) rich in energy (4754 kJ), fat (61.6 g), saturated fatty acids (53 % of total fatty acids), and carbohydrates (113.3 g) with either placebo or 54 mg quercetin. Blood pressure, reactive hyperemia index (RHI), high-sensitive C-reactive protein (hs-CRP), soluble endothelial-derived adhesion molecules, parameters of lipid and glucose metabolism, and markers of antioxidant status were measured before the meal and at 2 and 4 h postprandially.
   Results Systolic and diastolic blood pressure increased significantly over time, but were not affected by treatment (placebo or quercetin). During both treatments, serum endothelin-1, intercellular adhesion molecule-1, vascular cell adhesion molecule-1, and plasma asymmetric dimethylarginine slightly decreased over time, whereas RHI increased. Serum triglycerides, total cholesterol, and insulin significantly increased, whereas HDL cholesterol and glucose significantly decreased over time, again with no effect of treatment. Plasma alpha-tocopherol significantly increased, and plasma Trolox equivalent antioxidative capacity decreased over time. Serum hs-CRP, plasma retinol, and beta-carotene did not significantly change during the trial.
   Conclusion In hypertensive patients, a high-energy meal did not lead to postprandial impairment of vascular endothelial function. Postprandial metabolic responses induced by the challenge, such as lipemia and insulinemia, were not attenuated by the concomitant ingestion of quercetin.
C1 [Bruell, Verena; Burak, Constanze; Alteheld, Birgit; Stehle, Peter; Egert, Sarah] Univ Bonn, Dept Nutr & Food Sci Nutr Physiol, Endenicher Allee 11-13, D-53115 Bonn, Germany.
   [Stoffel-Wagner, Birgit] Univ Hosp Bonn, Inst Clin Chem & Clin Pharmacol, Bonn, Germany.
   [Wolffram, Siegfried] Christian Albrechts Univ Kiel, Inst Anim Nutr & Physiol, Kiel, Germany.
   [Nickenig, Georg; Mueller, Cornelius] Univ Hosp Bonn, Dept Cardiol Angiol & Pneumol, Bonn, Germany.
   [Langguth, Peter] Johannes Gutenberg Univ Mainz, Inst Pharm & Biochem, Dept Biopharmaceut & Pharmaceut Technol, Mainz, Germany.
   [Fimmers, Rolf] Univ Hosp Bonn, Inst Med Biometry Informat & Epidemiol, Bonn, Germany.
C3 University of Bonn; University of Bonn; University of Kiel; University
   of Bonn; Johannes Gutenberg University of Mainz; University of Bonn
RP Egert, S (corresponding author), Univ Bonn, Dept Nutr & Food Sci Nutr Physiol, Endenicher Allee 11-13, D-53115 Bonn, Germany.
EM s.egert@uni-bonn.de
RI Stehle, Peter/ITU-6185-2023
FU German Research Foundation [EG292/3-1]
FX The authors are indebted to our volunteers for their interest and
   participation in our study; to Rudolf Wild GmbH & Company KG (Matthias
   Sass) for the supply of the onion skin extract; to Petra Pickert,
   Margret Schuller, Christel Bierschbach, Adelheid Schuch, Anke Ernst,
   Petra Schulz, Anke Carstensen, and Ute Hartung for excellent technical
   assistance; and to Sarah Kronung, Elvis Kolobara, Claudia Pagliarucci,
   Lisa Albrecht, Ramona Napp, and Michael Napp for performing the
   venipunctures. This study was supported by Grant No. EG292/3-1 of the
   German Research Foundation (to SE).
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NR 48
TC 36
Z9 37
U1 1
U2 24
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1436-6207
EI 1436-6215
J9 EUR J NUTR
JI Eur. J. Nutr.
PD APR
PY 2017
VL 56
IS 3
BP 1347
EP 1357
DI 10.1007/s00394-016-1185-1
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA EO6OO
UT WOS:000396812600039
PM 26924303
DA 2025-06-11
ER

PT J
AU Kodavanti, UP
   Russell, JC
   Costa, DL
AF Kodavanti, Urmila P.
   Russell, James C.
   Costa, Daniel L.
TI Rat models of cardiometabolic diseases: baseline clinical chemistries,
   and rationale for their use in examining air pollution health effects
SO INHALATION TOXICOLOGY
LA English
DT Article
DE Air pollution; cardiovascular disease models; naturally occurring
   disease; rat models; susceptibility
ID SPONTANEOUSLY HYPERTENSIVE-RATS; DIESEL EXHAUST INHALATION; QUANTITATIVE
   TRAIT LOCI; HEART-RATE-VARIABILITY; BLOOD-PRESSURE;
   CARDIOVASCULAR-DISEASE; PARTICULATE MATTER; WISTAR-KYOTO; INDUCED
   PULMONARY; OXIDATIVE STRESS
AB Individuals with cardiovascular and metabolic diseases (CVD) are shown to be more susceptible to adverse health effects of pollutants. Rodent models of CVD are used for examining susceptibility variations. CVD models developed by selective inbreeding are shown to represent the etiology of human disease and metabolic dysfunction. The goal of this article was to review the origin and the pathobiological features of rat models of varying CVD with or without metabolic syndrome and healthy laboratory rat strains to allow better interpretation of the data regarding their susceptibility to air pollutant exposures. Age-matched healthy Sprague-Dawley (SD), Wistar (WIS) and Wistar Kyoto (WKY), and CVD-prone spontaneously hypertensive (SH), Fawn-Hooded hypertensive (FHH), SH stroke-prone (SHSP), SHHF/Mcc heart failure obese (SHHF) and insulin-resistant JCR:LA-cp obese (JCR) rat models were considered for this study. The genetics and the underlying pathologies differ between these models. Normalized heart weights correlated with underlying cardiac disease while wide differences exist in the number of white blood cells and platelets within healthy strains and those with CVD. High plasma fibrinogen and low angiotensin converting enzyme activity in FHH might relate to kidney disease and associated hypertension. However, other obese strains with known kidney lesions do not exhibit decreases in ACE activity. The increased activated partial thromboplastin time only in SHSP correlates with their hemorrhagic stroke susceptibility. Increases plasma lipid peroxidation in JCR might reflect their susceptibility to acquire atherosclerosis. These underlying pathologies involving CVD and metabolic dysfunction are critical in interpretation of findings related to susceptibility variations of air pollution health effects.
C1 [Kodavanti, Urmila P.] US EPA, NHEERL, Environmnetal Publ Hlth Div, Res Triangle Pk, NC USA.
   [Russell, James C.] Univ Alberta, Alberta Inst Human Nutr, Edmonton, AB, Canada.
   [Costa, Daniel L.] US EPA, Natl Program Air Climate & Energy Res, Off Res & Dev, Res Triangle Pk, NC 27709 USA.
C3 United States Environmental Protection Agency; University of Alberta;
   United States Environmental Protection Agency
RP Kodavanti, UP (corresponding author), US EPA, EPHD NHEERL, MD B143-01,109 TW Alexander Dr, Res Triangle Pk, NC 27709 USA.
EM kodavanti.urmila@epa.gov
RI Costa, Daniel/KJK-3910-2024
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NR 77
TC 12
Z9 12
U1 0
U2 14
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0895-8378
EI 1091-7691
J9 INHAL TOXICOL
JI Inhal. Toxicol.
PD MAR 20
PY 2015
VL 27
SU 1
SI SI
BP 2
EP 13
DI 10.3109/08958378.2014.954166
PG 12
WC Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Toxicology
GA CY7PX
UT WOS:000366601900002
PM 26667327
DA 2025-06-11
ER

PT J
AU Wronkowitz, N
   Görgens, SW
   Romacho, T
   Villalobos, LA
   Sánchez-Ferrer, CF
   Peiró, C
   Sell, H
   Eckel, J
AF Wronkowitz, Nina
   Goergens, Sven W.
   Romacho, Tania
   Villalobos, Laura A.
   Sanchez-Ferrer, Carlos F.
   Peiro, Concepcion
   Sell, Henrike
   Eckel, Juergen
TI Soluble DPP4 induces inflammation and proliferation of human smooth
   muscle cells via protease-activated receptor 2
SO BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
LA English
DT Article
DE DPP4; Smooth muscle cells; Proliferation; Inflammation; Adipokines;
   Atherosclerosis
ID DIPEPTIDYL-PEPTIDASE-IV; ATHEROSCLEROTIC LESION; CARDIOVASCULAR RISK;
   ADHESION MOLECULES; ADIPOSE-TISSUE; INHIBITOR; SITAGLIPTIN; OBESITY;
   METAANALYSIS; MITOGENESIS
AB DPP4 is an ubiquitously expressed cell-surface protease that is shedded to the circulation as soluble DPP4 (sDPP4). We recently identified sDPP4 as a novel adipokine potentially linking obesity to the metabolic syndrome. The aim of this study was to investigate direct effects of sDPP4 on human vascular smooth muscle cells (hVSMCs) and to identify responsible signaling pathways. Using physiological concentrations of sDPP4, we could observe a concentration-dependent activation of ERK1/2 (3-fold) after 6 h, which remained stable for up to 24 h. Additionally, 5DPP4 treatment induced a 1.5-fold phosphorylation of the NF-kappa B subunit p65. In accordance with sDPP4-induced stress and inflammatory signaling, sDPP4 also stimulates hVSMC proliferation. Furthermore we could observe an increased expression and secretion of pro-inflammatory cytokines like interleukin (IL)-6, IL-8 and MCP-1 (2.5-, 2.4- and 1.5-fold, respectively) by the 5DPP4 treatment. All direct effects of sDPP4 on signaling, proliferation and inflammation could completely be prevented by DPP4 inhibition. Bioinformatic analysis and signaling signature induced by sDPP4 suggest that 5DPP4 might be an agonist for PAR2. After the silencing of PAR2, the sDPP4-induced ERK activation as well as the proliferation was totally abolished. Additionally, the sDPP4-induced upregulation of IL-6 and IL-8 could completely be prevented by the PAR2 silencing. In conclusion, we show for the first time that 5DPP4 directly activates the MAPK and NF-kappa B signaling cascade involving PAR2 and resulting in the induction of inflammation and proliferation of hVSMC Thus, our in vitro data might extend the current view of sDPP4 action and shed light on cardiovascular effects of DPP4-inhibitors. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Wronkowitz, Nina; Goergens, Sven W.; Romacho, Tania; Sell, Henrike; Eckel, Juergen] German Diabet Ctr, Paul Langerhans Grp Integrat Physiol, D-40225 Dusseldorf, Germany.
   [Villalobos, Laura A.; Sanchez-Ferrer, Carlos F.; Peiro, Concepcion] Univ Autonoma Madrid, Sch Med, Dept Pharmacol & Therapeut, E-28049 Madrid, Spain.
C3 Leibniz Association; Deutsches Diabetes-Zentrum (DDZ); Autonomous
   University of Madrid
RP Sell, H (corresponding author), German Diabet Ctr, Paul Langerhans Grp Integrat Physiol, Aufm Hennekamp 65, D-40225 Dusseldorf, Germany.
EM Henrike.Sell@ddz.uni-duesseldorf.de
RI ; Peiro, Concepcion/B-9545-2017; Romacho, Tania/B-2663-2016; Sanchez
   Ferrer, Carlos Felix/J-8493-2014
OI Sell, Henrike/0000-0001-6323-6158; Eckel, Juergen/0000-0003-3645-5288;
   Peiro, Concepcion/0000-0002-9690-7816; Romacho,
   Tania/0000-0002-0962-7163; Sanchez Ferrer, Carlos
   Felix/0000-0002-7340-3156
FU Ministerium fur Wissenschaft und Forschung des Landes
   Nordrhein-Westfalen (Ministry of Science and Research of the State of
   North Rhine-Westphalia); Bundesministerium fur Gesundheit (Federal
   Ministry of Health); Deutsche Forschungsgemeinschaft [SE1922/2-2];
   EFSD-MSD; EFSD/Janssen Research Fellowship; DAAD-MICINN PPP
   [PRI-AIDBE-2011-0811]; Plan Nacional de I + D [SAF2011-28011,
   SAF2011-24648]; FP7 Marie Curie Intra-European Fellowship [2012-IEF-
   328793 ADDIO]
FX This work was supported by the Ministerium fur Wissenschaft und
   Forschung des Landes Nordrhein-Westfalen (Ministry of Science and
   Research of the State of North Rhine-Westphalia), the Bundesministerium
   fur Gesundheit (Federal Ministry of Health), the Deutsche
   Forschungsgemeinschaft (SE1922/2-2), an EFSD-MSD grant, an EFSD/Janssen
   Research Fellowship, a DAAD-MICINN PPP (PRI-AIDBE-2011-0811) and Plan
   Nacional de I + D (SAF2011-28011; SAF2011-24648). TR is the recipient of
   a FP7 Marie Curie Intra-European Fellowship (2012-IEF- 328793 ADDIO).
   The technical assistance of Andrea Cramer and Marlis Koenen and the
   secretarial assistance of Birgit Hurow are gratefully acknowledged.
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NR 49
TC 131
Z9 142
U1 0
U2 12
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0925-4439
EI 1879-260X
J9 BBA-MOL BASIS DIS
JI Biochim. Biophys. Acta-Mol. Basis Dis.
PD SEP
PY 2014
VL 1842
IS 9
BP 1613
EP 1621
DI 10.1016/j.bbadis.2014.06.004
PG 9
WC Biochemistry & Molecular Biology; Biophysics; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Cell Biology
GA AO0BZ
UT WOS:000340975400033
PM 24928308
OA Bronze
DA 2025-06-11
ER

PT J
AU Wagenaar, CA
   Walrabenstein, W
   van der Leeden, M
   Turkstra, F
   Gerritsen, M
   Twisk, JWR
   Boers, M
   van der Esch, M
   van Middendorp, H
   Weijs, PJM
   van Schaardenburg, D
AF Wagenaar, Carlijn A.
   Walrabenstein, Wendy
   van der Leeden, Marike
   Turkstra, Franktien
   Gerritsen, Martijn
   Twisk, Jos W. R.
   Boers, Maarten
   van der Esch, Martin
   van Middendorp, Henriet
   Weijs, Peter J. M.
   van Schaardenburg, Dirkjan
TI Two-Year Follow-Up of a Multidisciplinary Lifestyle Intervention for
   Rheumatoid Arthritis and Osteoarthritis
SO ARTHRITIS CARE & RESEARCH
LA English
DT Article; Early Access
ID AMERICAN-COLLEGE; CLASSIFICATION; CRITERIA; IMPROVEMENT; HIP
AB ObjectiveThe Plants for Joints (PFJ) intervention, including a whole-food plant-based diet, exercise, and stress reduction, reduced signs and symptoms of rheumatoid arthritis (RA) or metabolic syndrome-associated hip or knee osteoarthritis (MSOA) compared to usual care. This study aimed to examine outcomes two years after the PFJ intervention.MethodsAfter two 16-week randomized controlled trials in people with (1) RA or (2) MSOA, control groups received the active PFJ intervention. All participants were then observed in a two-year observational extension study. Primary outcomes were Disease Activity Score in 28 joints (DAS28) (RA) and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) (MSOA). Secondary outcomes included body composition, metabolic outcomes, medication changes, and adherence to intervention recommendations. Within-group differences were assessed using linear mixed models, comparing the start and end of the intervention to two years after intervention.ResultsA total of 48 of 77 participants with RA (62%) and 44 of 64 participants with MSOA (69%) completed the extension study. Two years after the intervention, the DAS28 in participants with RA (-0.9 points, 95% confidence interval [CI] -1.2 to -0.6 points) and WOMAC score in participants with MSOA (-8.8 points, 95% CI -12.6 to -5.1 points) were significantly lower than start intervention. In addition, C-reactive protein in the RA group and weight, body mass index, waist circumference, and diastolic blood pressure in the MSOA group were significantly lower compared to start intervention. Primary end points remained similar from the end of the intervention to the end of the extension study. During the extension study, medication use decreased slightly, and participants continued to follow the intervention recommendations.ConclusionTwo years after the PFJ intervention, improvements in RA disease activity, MSOA symptoms and functioning, and intervention adherence were sustained. imageConclusionTwo years after the PFJ intervention, improvements in RA disease activity, MSOA symptoms and functioning, and intervention adherence were sustained. image
C1 [Wagenaar, Carlijn A.; Walrabenstein, Wendy; van Schaardenburg, Dirkjan] Univ Amsterdam, Amsterdam Univ Med Ctr, Reade Ctr Rheumatol & Rehabil, Amsterdam, Netherlands.
   [Wagenaar, Carlijn A.; Walrabenstein, Wendy; van Schaardenburg, Dirkjan] Amsterdam Rheumatol & Immunol Ctr, Amsterdam, Netherlands.
   [van der Leeden, Marike] Vrije Univ, Amsterdam Univ Med Ctr, Reade Ctr Rheumatol & Rehabil, Amsterdam, Netherlands.
   [van der Leeden, Marike] Amsterdam Movement Sci Res Inst, Amsterdam, Netherlands.
   [Turkstra, Franktien; Gerritsen, Martijn; van der Esch, Martin] Reade Ctr Rheumatol & Rehabil, Amsterdam, Netherlands.
   [Twisk, Jos W. R.; Boers, Maarten; Weijs, Peter J. M.] Vrije Univ, Amsterdam Univ Med Ctr, Amsterdam, Netherlands.
   [van der Esch, Martin; Weijs, Peter J. M.] Amsterdam Univ Appl Sci, Amsterdam, Netherlands.
   [van Middendorp, Henriet] Leiden Univ, Leiden, Netherlands.
C3 University of Amsterdam; Vrije Universiteit Amsterdam; Vrije
   Universiteit Amsterdam; Vrije Universiteit Amsterdam; Leiden University
   - Excl LUMC; Leiden University
RP Wagenaar, CA (corresponding author), Univ Amsterdam, Amsterdam Univ Med Ctr, Reade Ctr Rheumatol & Rehabil, Amsterdam, Netherlands.; Wagenaar, CA (corresponding author), Amsterdam Rheumatol & Immunol Ctr, Amsterdam, Netherlands.
EM c.a.wagenaar@amsterdamumc.nl
FU W.M. de Hoop Stichting
FX We thank the Reade Biobank technicians Toni de Jong-de Boer and Corrie
   Verdoold, radiologist Mies Korteweg; registered dietitians Pauline
   Kortbeek, Anna Kretova, Melissa Dijkshoorn, Marieke van de Put, Michelle
   Bisschops, Alie Tooonstra, and Sanne Kodde; and Martijn Gerritsen,
   Sjoerd Heslinga, and Bas Dijkshoorn (Medication Committee). During the
   preparation of this work, the authors used ChatGPT to improve
   readability and language by checking grammar and making suggestions for
   improving sentence structure. After using this tool, the authors
   reviewed and edited the content as needed and take full responsibility
   for the content of the publication.
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NR 15
TC 0
Z9 0
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2151-464X
EI 2151-4658
J9 ARTHRIT CARE RES
JI Arthritis Care Res.
PD 2025 JUN 4
PY 2025
DI 10.1002/acr.25553
EA JUN 2025
PG 8
WC Rheumatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Rheumatology
GA 3JI8N
UT WOS:001501736100001
PM 40254971
DA 2025-06-11
ER

PT J
AU Kandel, A
   Pant, P
   Todi, S
   Kc, S
   Pandey, S
AF Kandel, Amrita
   Pant, Poonam
   Todi, Sushila
   Kc, Sudhamshu
   Pandey, Sudip
TI Effect of exercise and pharmacotherapy on non-alcoholic fatty liver
   disease
SO SAGE OPEN MEDICINE
LA English
DT Article
DE Non-alcoholic fatty liver disease; risk factors; exercise;
   pharmacotherapy
ID PHYSICAL-ACTIVITY; METABOLIC SYNDROME; POSITION PAPER; LIPID PROFILE;
   SITTING TIME; WEIGHT-LOSS; PREVALENCE; INTERVENTION; ASSOCIATION;
   POPULATION
AB Objectives: Nonalcoholic fatty liver disease is one of the emerging liver diseases affecting 20%-30% of the population creating a burden on public health worldwide and has been associated with the causation of multiple diseases. Besides exercise, several drugs are being used in patients based on clinical evidence especially vitamin E, a potent antioxidant to reduce the oxidative stress responsible for the development and progression of nonalcoholic fatty liver disease. This study aims at evaluating the effect of exercise and pharmacotherapy on nonalcoholic fatty liver disease. Design: A prospective follow-up study with purposive sampling was done at a liver clinic for 3 months. Baseline characteristics such as anthropometric measurements and biochemical parameters were recorded and compared after 3 months to determine the effect of therapy. Descriptive analysis using a parametric test was used to assess the change in biochemical parameters and a non-parametric test was applied to find out the association between non-pharmacological and pharmacological approaches. Results: Out of 177 patients, 67.2 % were male and 32.8% were female with the mean age +/- SD of 46.8 +/- 12.06 years. Mean +/- SD weight and body mass index of the patients were changed from 74.88 +/- 11.61 kg to 72.37 +/- 11.61 kg and from 28.41 +/- 4.02 kg/m(2) to 27.31 +/- 4.58 kg/m(2) respectively which was found to be statistically significant. There was a significant change in all the biochemical parameters with the p-value < 0.05 through both non-pharmacological and pharmacological approaches. Conclusion: Nonalcoholic fatty liver disease management through exercise and pharmacotherapy shows significant improvement in biochemical parameters indicating that alone or in combination with both approaches play an effective role in treating nonalcoholic fatty liver disease.
C1 [Kandel, Amrita; Pant, Poonam] CiST Coll, Pharm Program, Kathmandu, Nepal.
   [Todi, Sushila] Patan Acad Hlth Sci, Obstet Dept, Kathmandu, Nepal.
   [Todi, Sushila] Patan Acad Hlth Sci, Gynaecol Dept, Kathmandu, Nepal.
   [Kc, Sudhamshu] Bir Hosp, NAMS, Hepatol Dept, Kathmandu, Nepal.
   [Pandey, Sudip] Madan Bhandari Univ Sci & Technol, Lalitpur, Nepal.
   [Pant, Poonam] CiST Coll, Pharm Program, Sangam Chowk, Kathmandu 44600, Nepal.
RP Pant, P (corresponding author), CiST Coll, Pharm Program, Sangam Chowk, Kathmandu 44600, Nepal.
EM poonampant@cist.edu.np
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NR 39
TC 2
Z9 2
U1 0
U2 3
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 2050-3121
J9 SAGE OPEN MED
JI SAGE Open Med.
PY 2024
VL 12
AR 20503121241227090
DI 10.1177/20503121241227090
PG 8
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA GD0J2
UT WOS:001150605800001
PM 38283643
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Han, FY
   Yu, C
   Hu, F
   Zhou, W
   Wang, T
   Zhu, LJ
   Huang, X
   Bao, HH
   Cheng, XS
AF Han, Fengyu
   Yu, Chao
   Hu, Feng
   Zhou, Wei
   Wang, Tao
   Zhu, Linjuan
   Huang, Xiao
   Bao, Huihui
   Cheng, Xiaoshu
TI Association between serum uric acid levels and peripheral artery disease
   in Chinese adults with hypertension
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Article
DE serum uric acid; peripheral artery disease; hyperuricemia; hypertension;
   adult
ID ATRIAL-FIBRILLATION; METABOLIC SYNDROME; MORTALITY; RISK;
   ATHEROSCLEROSIS; THROMBOEMBOLISM; HYPERURICEMIA; MANAGEMENT; STROKE;
   INDEX
AB Background: Higher serum uric acid (SUA) can cause gout, which is principally characterized by arthritis due to monosodium urate crystal deposition in the lower extremities. High levels of SUA have been linked to endothelial dysfunction, oxidative stress, and inflammation, all of which are involved in the pathogenesis of peripheral artery disease(PAD). To date, the relationship between SUA levels and PAD is still poorly understood.
   Method: An analysis of 9,839 Chinese adults with essential hypertension from the ongoing China H-type Hypertension Registry Study was conducted in this cross- sectional study. Patients with an ABI <= 0.9 was diagnosed with PAD. Hyperuricemia was defined as SUA levels >420 mol/L in men and >360 mol/L in women. The association between SUA levels and PAD was evaluated using multivariable logistic regression models based on odds ratios (ORs) and their 95% confidence intervals (CIs).
   Results: The enrolled subjects ranged in age from 27 to 93 years, with a mean age of 63.14 +/- 8.99 years. The proportion of male patients was 46.22%, and the prevalence of hyperuricemia was 50.72%. In males, hyperuricemia was positively associated with the risk of PAD (adjusted OR per SD increase: 1.72, 95% CI 1.17 to 2.53, P =0.006). Males in the highest SUA tertile were significantly more likely to have PAD (adjusted OR: 2.63, 95% CI 1.42 to 4.86, P = 0.002; P for trend = 0.001). However, this positive relationship was not observed in females (adjusted OR: 1.29, 95% CI 0.77 to 2.17, P = 0.327; P for trend = 0.347).
   Conclusion: According to this cross-sectional study, higher SUA levels were positively associated with PAD in male hypertensive patients, while this positive relationship disappeared in female participants.
C1 [Han, Fengyu; Hu, Feng; Huang, Xiao; Bao, Huihui; Cheng, Xiaoshu] Nanchang Univ, Affiliated Hosp 2, Dept Cardiovasc Med, Nanchang, Jiangxi, Peoples R China.
   [Han, Fengyu; Yu, Chao; Hu, Feng; Zhou, Wei; Wang, Tao; Zhu, Linjuan; Huang, Xiao; Bao, Huihui; Cheng, Xiaoshu] Jiangxi Prov Cardiovasc Dis Clin Med Res Ctr, Nanchang, Jiangxi, Peoples R China.
   [Han, Fengyu; Yu, Chao; Hu, Feng; Zhou, Wei; Wang, Tao; Zhu, Linjuan; Huang, Xiao; Bao, Huihui; Cheng, Xiaoshu] Jiangxi Sub Ctr Natl Clin Res Ctr Cardiovasc Dis, Nanchang, Jiangxi, Peoples R China.
   [Yu, Chao; Zhou, Wei; Wang, Tao; Zhu, Linjuan; Huang, Xiao; Bao, Huihui; Cheng, Xiaoshu] Nanchang Univ, Ctr Prevent & Treatment Cardiovasc Dis, Affiliated Hosp 2, Nanchang, Jiangxi, Peoples R China.
C3 Nanchang University; Nanchang University
RP Bao, HH (corresponding author), Nanchang Univ, Affiliated Hosp 2, Dept Cardiovasc Med, Nanchang, Jiangxi, Peoples R China.; Bao, HH (corresponding author), Jiangxi Prov Cardiovasc Dis Clin Med Res Ctr, Nanchang, Jiangxi, Peoples R China.; Bao, HH (corresponding author), Jiangxi Sub Ctr Natl Clin Res Ctr Cardiovasc Dis, Nanchang, Jiangxi, Peoples R China.; Bao, HH (corresponding author), Nanchang Univ, Ctr Prevent & Treatment Cardiovasc Dis, Affiliated Hosp 2, Nanchang, Jiangxi, Peoples R China.
EM huihui_bao77@126.com
RI Han, Fengyu/JFA-4460-2023; Yu, Chao/JHT-2597-2023; HUANG,
   XIAO/ABB-9211-2020; Hu, Feng/KYY-9200-2024; xiaoyu, zhang/JXY-7226-2024
OI Yu, Chao/0000-0002-8525-5920; Han, Fengyu/0000-0002-0576-9631
FU Cultivation of backup projects for the National Science and Technology
   Awards [20223AEI91007]; Jiangxi Science and Technology Innovation Base
   Plan - Jiangxi Clinical Medical Research Center [20223BCG74012]; Science
   and Technology Innovation Base Construction Project [20221ZDG02010];
   Jiangxi Science and Technology Innovation Platform Project
   [20165BCD41005]; Jiangxi Provincial Natural Science Foundation
   [20212ACB206019, 20224BAB206090]; Key R&D Projects, Jiangxi
   [20203BBGL73173]; Jiangxi Provincial Health Commission Science and
   Technology Project [202130440, 202210495, 202310528]; Jiangxi Provincial
   Drug Administration Science and Technology Project [2022JS41]; Second
   Affiliated Hospital of Nanchang University [2016YNQN12034,
   2019YNLZ12010, 2021efyA01, 2021YNFY2024]
FX This work was supported by the Cultivation of backup projects for the
   National Science and Technology Awards (20223AEI91007), Jiangxi Science
   and Technology Innovation Base Plan - Jiangxi Clinical Medical Research
   Center (20223BCG74012), and the Science and Technology Innovation Base
   Construction Project (20221ZDG02010). It was a Jiangxi Science and
   Technology Innovation Platform Project (20165BCD41005) and also
   supported by the Jiangxi Provincial Natural Science Foundation
   (20212ACB206019, 20224BAB206090), Key R&D Projects, Jiangxi
   (20203BBGL73173), Jiangxi Provincial Health Commission Science and
   Technology Project (202130440,202210495,202310528), Jiangxi Provincial
   Drug Administration Science and Technology Project (2022JS41), and was a
   Fund project of the Second Affiliated Hospital of Nanchang University
   (2016YNQN12034, 2019YNLZ12010, 2021efyA01, 2021YNFY2024).
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NR 52
TC 7
Z9 7
U1 0
U2 5
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD AUG 22
PY 2023
VL 14
AR 1197628
DI 10.3389/fendo.2023.1197628
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA R0UK1
UT WOS:001061577400001
PM 37674616
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Krishnan, KC
   Hachem, EJ
   Keller, M
   Patel, SG
   Carroll, L
   Vegas, AD
   Gyuricza, IG
   Light, C
   Cao, Y
   Pan, C
   Kaczor-Urbanowicz, KE
   Shravah, V
   Anum, D
   Pellegrini, M
   Lee, CF
   Seldin, MM
   Rosenthal, NA
   Churchill, GA
   Attie, A
   Parker, B
   James, DE
   Lusis, AJ
AF Krishnan, Karthickeyan Chella
   El Hachem, Elie-Julien
   Keller, Mark
   Patel, Sanjeet G.
   Carroll, Luke
   Vegas, Alexis Diaz
   Gyuricza, Isabela Gerdes
   Light, Christine
   Cao, Yang
   Pan, Calvin
   Kaczor-Urbanowicz, Karolina Elzbieta
   Shravah, Varun
   Anum, Diana
   Pellegrini, Matteo
   Lee, Chi Fung
   Seldin, Marcus M.
   Rosenthal, Nadia A.
   Churchill, Gary A.
   Attie, Alan
   Parker, Benjamin
   James, David E.
   Lusis, Aldons J.
TI Genetic architecture of heart mitochondrial proteome influencing cardiac
   hypertrophy
SO ELIFE
LA English
DT Article
DE proteomics; metabolic syndrome; genetic; association studies;
   mitochondria; hypertrophy; heart failure
ID GUT MICROBIOTA COMPOSITION; MOUSE DIVERSITY PANEL; INSULIN-RESISTANCE;
   DYSFUNCTION; NDUFS4; EXPRESSION; MUTATIONS; POLYADENYLATION;
   IDENTIFICATION; ASSOCIATION
AB Mitochondria play an important role in both normal heart function and disease etiology. We report analysis of common genetic variations contributing to mitochondrial and heart functions using an integrative proteomics approach in a panel of inbred mouse strains called the Hybrid Mouse Diversity Panel (HMDP). We performed a whole heart proteome study in the HMDP (72 strains, n=2-3 mice) and retrieved 848 mitochondrial proteins (quantified in =50 strains). High-resolution association mapping on their relative abundance levels revealed three trans-acting genetic loci on chromosomes (chr) 7, 13 and 17 that regulate distinct classes of mitochondrial proteins as well as cardiac hypertrophy. DAVID enrichment analyses of genes regulated by each of the loci revealed that the chr13 locus was highly enriched for complex-I proteins (24 proteins, P=2.2E-61), the chr17 locus for mitochondrial ribonucleoprotein complex (17 proteins, P=3.1E-25) and the chr7 locus for ubiquinone biosynthesis (3 proteins, P=6.9E-05). Follow-up high resolution regional mapping identified NDUFS4, LRPPRC and COQ7 as the candidate genes for chr13, chr17 and chr7 loci, respectively, and both experimental and statistical analyses supported their causal roles. Furthermore, a large cohort of Diversity Outbred mice was used to corroborate Lrpprc gene as a driver of mitochondrial DNA (mtDNA)-encoded gene regulation, and to show that the chr17 locus is specific to heart. Variations in all three loci were associated with heart mass in at least one of two independent heart stress models, namely, isoproterenol-induced heart failure and diet-induced obesity. These findings suggest that common variations in certain mitochondrial proteins can act in trans to influence tissue-specific mitochondrial functions and contribute to heart hypertrophy, elucidating mechanisms that may underlie genetic susceptibility to heart failure in human populations.
C1 [Krishnan, Karthickeyan Chella] Univ Cincinnati, Dept Pharmacol & Syst Physiol, Coll Med, Cincinnati, OH 45221 USA.
   [El Hachem, Elie-Julien] Sci Sorbonne Univ, Dept Integrat Biol & Physiol, Field Syst Biol, Paris, France.
   [Keller, Mark] Univ Wisconsin Madison, Dept Biochem, Madison, WI USA.
   [Patel, Sanjeet G.] Univ Southern Calif, Dept Surg, Keck Sch Med, Div Cardiac Surg, Los Angeles, CA USA.
   [Carroll, Luke; James, David E.] Univ Sydney, Sch Life & Environm Sci, Charles Perkins Ctr, Metab Syst Biol Lab, Sydney, NSW, Australia.
   [Vegas, Alexis Diaz; Rosenthal, Nadia A.; Churchill, Gary A.] Jackson Lab, 600 Main St, Bar Harbor, ME 04609 USA.
   [Light, Christine] Oklahoma Med Res Fdn, Cardiovasc Biol Res Program, 825 NE 13th St, Oklahoma City, OK 73104 USA.
   [Cao, Yang; Pan, Calvin; Lusis, Aldons J.] Univ Calif Los Angeles, Dept Med, Div Cardiol, Los Angeles, CA 90095 USA.
   [Kaczor-Urbanowicz, Karolina Elzbieta] Univ Calif Los Angeles, Div Oral Biol & Med, Sch Dent, Los Angeles, CA USA.
   [Kaczor-Urbanowicz, Karolina Elzbieta; Pellegrini, Matteo] Univ Calif Los Angeles, Inst Quantitat & Computat Biosci, Los Angeles, CA USA.
   [Shravah, Varun] Univ Calif Los Angeles, Dept Chem, Los Angeles, CA USA.
   [Anum, Diana] Univ Calif Los Angeles, Dept Integrat Biol & Physiol, Los Angeles, CA USA.
   [Lee, Chi Fung] Univ Oklahoma, Dept Physiol, Hlth Sci Ctr, Oklahoma City, OK USA.
   [Seldin, Marcus M.] Ctr Epigenet & Metab, Irvine, CA USA.
   [Seldin, Marcus M.] Univ Calif Irvine, Dept Biol Chem, Irvine, CA USA.
   [Parker, Benjamin] Univ Melbourne, Dept Anat & Physiol, Melbourne, Vic, Australia.
   [Lusis, Aldons J.] Univ Calif Los Angeles, Dept Human Genet, Los Angeles, CA 90095 USA.
   [Lusis, Aldons J.] Univ Calif Los Angeles, Dept Microbiol Immunol & Mol Genet, Los Angeles, CA 90095 USA.
C3 University System of Ohio; University of Cincinnati; University of
   Wisconsin System; University of Wisconsin Madison; University of
   Southern California; University of Sydney; Jackson Laboratory; Oklahoma
   Medical Research Foundation; University of California System; University
   of California Los Angeles; University of California System; University
   of California Los Angeles; University of California System; University
   of California Los Angeles; University of California System; University
   of California Los Angeles; University of California System; University
   of California Los Angeles; University of Oklahoma System; University of
   Oklahoma Health Sciences Center; University of California System;
   University of California Irvine; University of Melbourne; University of
   California System; University of California Los Angeles; University of
   California System; University of California Los Angeles
RP Krishnan, KC (corresponding author), Univ Cincinnati, Dept Pharmacol & Syst Physiol, Coll Med, Cincinnati, OH 45221 USA.; Lusis, AJ (corresponding author), Univ Calif Los Angeles, Dept Med, Div Cardiol, Los Angeles, CA 90095 USA.; Lusis, AJ (corresponding author), Univ Calif Los Angeles, Dept Human Genet, Los Angeles, CA 90095 USA.; Lusis, AJ (corresponding author), Univ Calif Los Angeles, Dept Microbiol Immunol & Mol Genet, Los Angeles, CA 90095 USA.
EM chellakn@ucmail.uc.edu; JLusis@mednet.ucla.edu
RI James, David/KYY-9051-2024; Diaz-Vegas, Alexis/Z-4026-2019;
   ChellaKrishnan, Karthickeyan/H-6828-2019; Rosenthal, Nadia/H-4012-2013;
   Carroll, Luke/E-9366-2015; Churchill, Gary/AAY-7496-2020; Pellegrini,
   Matteo/AFS-3694-2022; El Hachem, Elie-Julien/LJL-5487-2024; Diaz Vegas,
   Alexis/I-1941-2013
OI Shravah, Varun/0000-0002-7734-7825; Chella Krishnan,
   Karthickeyan/0000-0002-4895-2495; Anum, Diana/0009-0009-8931-3719; Diaz
   Vegas, Alexis/0000-0001-5227-4482; El Hachem,
   Elie-Julien/0000-0001-5033-6117; Rosenthal, Nadia/0000-0002-7599-7365
FU National Institutes of Health [DK120342, R00DK120875, R00HL138193,
   R01DK101573, R01DK102948, RC2DK125961, HL148577, HL147883]; U.S.
   Department of Defense [W81XWH2110115]; National Health and Medical
   Research Council; Systems Biology Association fellowship; Foundation
   Sorbonne fellowship; French Minister and Master BIP; National Heart Lung
   and Blood Institute [R01HL147883, R00HL138193] Funding Source: NIH
   RePORTER; National Institute of Diabetes and Digestive and Kidney
   Diseases; NIH Office of the Director [U54DK120342] Funding Source: NIH
   RePORTER
FX National Institutes of Health DK120342 Aldons J LusisNational Institutes
   of Health R00DK120875 Karthickeyan Chella KrishnanNational Institutes of
   Health R00HL138193 Marcus M SeldinNational Institutes of Health
   R01DK101573 Alan AttieU.S. Department of Defense W81XWH2110115 Aldons J
   Lusis Wisconsin Alumni Research Foundation Mark KellerNational Health
   and Medical Research Council Benjamin ParkerNational Institutes of
   Health R01DK102948 Alan AttieNational Institutes of Health RC2DK125961
   Alan AttieNational Institutes of Health HL148577 Aldons J LusisNational
   Institutes of Health HL147883 Aldons J LusisSystems Biology Association
   fellowship Elie-Julien El HachemFoundation Sorbonne fellowship
   Elie-Julien El HachemFrench Minister and Master BIP Elie-Julien El
   HachemThe funders had no role in study design, data collection and
   interpretation, or the decision to submit the work for publication.
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NR 87
TC 4
Z9 4
U1 0
U2 3
PU eLIFE SCIENCES PUBL LTD
PI CAMBRIDGE
PA SHERATON HOUSE, CASTLE PARK, CAMBRIDGE, CB3 0AX, ENGLAND
SN 2050-084X
J9 ELIFE
JI eLife
PD JUN 5
PY 2023
VL 12
AR e82619
DI 10.7554/eLife.82619
PG 22
WC Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics
GA S5RF7
UT WOS:001071729700001
PM 37276142
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Hung, WC
   Yu, TH
   Wu, CC
   Lee, TL
   Tsai, IT
   Hsuan, CF
   Chen, CY
   Chung, FM
   Lee, YJ
   Tang, WH
AF Hung, Wei-Chin
   Yu, Teng-Hung
   Wu, Cheng-Ching
   Lee, Thung-Lip
   Tsai, I-Ting
   Hsuan, Chin-Feng
   Chen, Chun-Yu
   Chung, Fu-Mei
   Lee, Yau-Jiunn
   Tang, Wei-Hua
TI FABP3, FABP4, and heart rate variability among patients with chronic
   schizophrenia
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Article
DE schizophrenia; cardiovascular disease; heart rate variability; high
   frequency; low-frequency; fatty acid-binding protein
ID ACID-BINDING PROTEIN; CHRONIC KIDNEY-DISEASE; INFLAMMATORY MARKERS;
   AUTONOMIC FUNCTION; METABOLIC SYNDROME; STRESS; RELIABILITY; BIOMARKER;
   RESPONSES; FITNESS
AB IntroductionThe prevalence of cardiovascular disease (CVD) and CVD-related deaths in patients with schizophrenia is high. An elevated risk of CVD has been associated with low heart rate variability (HRV). There is increasing evidence that fatty acid-binding protein (FABP)3 and FABP4 play roles in the development and progression of CVD. This study aimed to explore the association of circulating FABP3/FABP4 levels with HRV in patients with chronic schizophrenia. MethodsWe included 265 consecutive patients with chronic schizophrenia who attended a disease management program. We used an enzyme-linked immunosorbent assay for the measurement of plasma concentrations of FABP3 and FABP4. Standard HRV was recorded at baseline following a standard protocol. Mean high- and low-frequency (HF/LF) HRV values were analyzed by tertile of FABP3 and FABP4 using one-way analysis of variance, and linear regression analysis was performed to assess trends. ResultsA positive association between FABP3 and creatinine was found in multiple regression analysis. In addition, negative associations between levels of hematocrit, hemoglobin, HF HRV, and estimated glomerular filtration rate (eGFR) with FABP3 were also found. Moreover, positive associations between FABP4 with body mass index, diabetes mellitus, hypertension, systolic blood pressure, low-density lipoprotein-cholesterol, triglycerides, creatinine, and FABP3 were found. Furthermore, negative associations between levels of high-density lipoprotein-cholesterol, eGFR, and HF HRV with FABP4 were found. We also found a significant inverse association between FABP3 and HF HRV (p for trend = 0.008), and significant inverse associations between FABP4 with HF and LF HRV (p for trend = 0.007 and 0.017, respectively). DiscussionTogether, this suggests that elevated levels of FABP3 and FABP4 may be linked to health problems related to CVD in patients with chronic schizophrenia.
C1 [Hung, Wei-Chin; Yu, Teng-Hung; Wu, Cheng-Ching; Lee, Thung-Lip; Hsuan, Chin-Feng; Chung, Fu-Mei] I Shou Univ, E Da Hosp, Dept Internal Med, Div Cardiol, Kaohsiung, Taiwan.
   [Hung, Wei-Chin; Yu, Teng-Hung; Wu, Cheng-Ching; Tsai, I-Ting; Hsuan, Chin-Feng] I Shou Univ, Coll Med, Sch Med, Kaohsiung, Taiwan.
   [Wu, Cheng-Ching] I Shou Univ, E Da Canc Hosp, Dept Internal Med, Div Cardiol, Kaohsiung, Taiwan.
   [Lee, Thung-Lip] I Shou Univ, Coll Med, Sch Med Int Students, Kaohsiung, Taiwan.
   [Tsai, I-Ting] I Shou Univ, E Da Hosp, Dept Emergency, Kaohsiung, Taiwan.
   [Hsuan, Chin-Feng] I Shou Univ, E Da Dachang Hosp, Dept Internal Med, Div Cardiol, Kaohsiung, Taiwan.
   [Chen, Chun-Yu] Taipei Vet Gen Hosp, Neurol Inst, Div Gen Neurol, Taipei, Taiwan.
   [Lee, Yau-Jiunn] Lees Endocrinol Clin, Dept Head, Pingtung, Taiwan.
   [Tang, Wei-Hua] Taipei Vet Gen Hosp, Dept Internal Med, Div Cardiol, Yuli Branch, Hualien, Taiwan.
   [Tang, Wei-Hua] Natl Yang Ming Chiao Tung Univ, Fac Med, Sch Med, Taipei, Taiwan.
C3 E-Da Hospital; I Shou University; I Shou University; I Shou University;
   E-Da Hospital; I Shou University; I Shou University; E-Da Hospital; I
   Shou University; E-Da Hospital; Taipei Veterans General Hospital; Taipei
   Veterans General Hospital; National Yang Ming Chiao Tung University
RP Tang, WH (corresponding author), Taipei Vet Gen Hosp, Dept Internal Med, Div Cardiol, Yuli Branch, Hualien, Taiwan.; Tang, WH (corresponding author), Natl Yang Ming Chiao Tung Univ, Fac Med, Sch Med, Taipei, Taiwan.
EM africapaul12@yahoo.com
RI Chen, Chun-Yu/L-7084-2013
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NR 70
TC 3
Z9 3
U1 1
U2 5
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD MAY 15
PY 2023
VL 14
AR 1165621
DI 10.3389/fendo.2023.1165621
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA H3GE9
UT WOS:000994876200001
PM 37255976
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Karbasi, S
   Bahrami, A
   Hanafi-Bojd, MY
   Khorasanchi, Z
   Zarban, A
   Ferns, GA
AF Karbasi, Samira
   Bahrami, Afsane
   Hanafi-Bojd, Mohammad Yahya
   Khorasanchi, Zahra
   Zarban, Asghar
   Ferns, Gordon A.
TI Maternal Adherence to a Dietary Approaches to Stop Hypertension (DASH)
   Dietary Pattern and the Relationship to Breast Milk Nutrient Content
SO MATERNAL AND CHILD HEALTH JOURNAL
LA English
DT Article
DE DASH dietary pattern; Antioxidant content; Breast milk; Lactating women;
   Infants
ID BONE-MINERAL DENSITY; OXIDATIVE STRESS; METABOLIC SYNDROME; 3RD
   TRIMESTER; CARDIOVASCULAR HEALTH; BODY-COMPOSITION; STYLE DIET; CALCIUM;
   WOMEN; SUPPLEMENTATION
AB Background Maternal lifestyle factors, such as diet and nutritional status are likely to affect the composition of breast milk (BM). This study aimed to investigate the association between adherence to a Dietary Approaches to Stop Hypertension (DASH) dietary pattern (DP) and BM nutrient content.Method A total of 700 milk samples were obtained from 350 lactating women. The dietary intakes of the women in the study were estimated using a validated food frequency questionnaire, which included 65 food items. The total antioxidant activity (TAC) of BM samples was evaluated using the Ferric reducing antioxidant power (FRAP), 2,2 '-diphenyl-1-picrylhydrazyl (DPPH), thiobarbituric acid reactive substances (TBARS), and Ellman's assay. Also using commercially available kits, the total protein, calcium, and triglyceride contents in milk were determined.Results Individuals in the 3rd tertile of adherence to the DASH diet (highest adherence) consumed more dietary fiber, fruits, vegetables, nuts, legumes, and seeds, low-fat dairy, whole grain, less red and processed meat, sweetened beverages, and sodium than those in the first tertile (lowest adherence). Subjects in the 3rd tertile of DASH DP had higher values of milk DPPH and calcium compared to those in the first tertile (P < 0.05). Milk MDA and triglyceride were significantly lower in the 3rd tertile of DASH diet versus the first tertile (P < 0.05).Conclusion Our study showed that high adherence to the DASH DP was associated with higher BM DPPH and calcium levels and lower amounts of BM MDA and triglyceride. The adherence to the healthy DPs such as the DASH can improve the quality of BM in lactating women.
C1 [Karbasi, Samira] Birjand Univ Med Sci, Cardiovasc Dis Res Ctr, Sch Med, Dept Mol Med, Birjand, Iran.
   [Bahrami, Afsane] Mashhad Univ Med Sci, Clin Res Dev Unit, Akbar Hosp, Mashhad, Iran.
   [Bahrami, Afsane] Mashhad Univ Med Sci, Imam Reza Hosp, Fac Med, Clin Res Dev Unit, Mashhad, Iran.
   [Hanafi-Bojd, Mohammad Yahya] Birjand Univ Med Sci, Cellular & Mol Res Ctr, Mol Med Dept, Birjand, Iran.
   [Hanafi-Bojd, Mohammad Yahya] Birjand Univ Med Sci, Sch Pharm, Dept Pharmaceut & Pharmaceut Nanotechnol, Birjand, Iran.
   [Khorasanchi, Zahra] Mashhad Univ Med Sci, Sch Med, Dept Nutr, Mashhad, Iran.
   [Zarban, Asghar] Birjand Univ Med Sci, Cardiovasc Dis Res Ctr, Birjand, Iran.
   [Zarban, Asghar] Birjand Univ Med Sci, Fac Med, Clin Biochem Dept, Birjand, Iran.
   [Ferns, Gordon A.] Brighton & Sussex Med Sch, Dept Med Educ, Brighton BN1 9PH, E Sussex, England.
C3 Birjand University of Medical Sciences; Mashhad University of Medical
   Sciences; Mashhad University of Medical Sciences; Birjand University of
   Medical Sciences; Birjand University of Medical Sciences; Mashhad
   University of Medical Sciences; Birjand University of Medical Sciences;
   Birjand University of Medical Sciences; University of Sussex; University
   of Brighton
RP Zarban, A (corresponding author), Birjand Univ Med Sci, Cardiovasc Dis Res Ctr, Birjand, Iran.; Zarban, A (corresponding author), Birjand Univ Med Sci, Fac Med, Clin Biochem Dept, Birjand, Iran.
EM azarban@bums.ac.ir
RI Zarban, Asghar/O-1628-2017; khorasanchi, zahra/ABD-4405-2021; bahrami,
   afsaneh/Q-3369-2018; Hanafi-Bojd, Mohammad/L-9605-2017
OI khorasanchi, zahra/0000-0001-9579-9465; Bahrami,
   Afsane/0000-0002-4563-6112
FU Birjand University of Medical Science (BUMS), Iran [456333]
FX This work was supported by Birjand University of Medical Science (BUMS)
   (Grant No. 456333), Iran.
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NR 81
TC 4
Z9 4
U1 1
U2 8
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1092-7875
EI 1573-6628
J9 MATERN CHILD HLTH J
JI Matern. Child Health J.
PD FEB
PY 2023
VL 27
IS 2
BP 385
EP 394
DI 10.1007/s10995-022-03552-w
EA JAN 2023
PG 10
WC Public, Environmental & Occupational Health
WE Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA 8P7GO
UT WOS:000910030000001
PM 36607482
DA 2025-06-11
ER

PT J
AU Zhu, YC
   Ji, HF
   Niu, Z
   Liu, HM
   Wu, XH
   Yang, L
   Wang, ZW
   Chen, J
   Fang, YR
AF Zhu, Yuncheng
   Ji, Haifeng
   Niu, Zhiang
   Liu, Hongmei
   Wu, Xiaohui
   Yang, Lu
   Wang, Zuowei
   Chen, Jun
   Fang, Yiru
TI Biochemical and Endocrine Parameters for the Discrimination and
   Calibration of Bipolar Disorder or Major Depressive Disorder
SO FRONTIERS IN PSYCHIATRY
LA English
DT Article
DE bipolar disorder; major depressive disorder; mood disorders; gender;
   biological markers
ID PLATELET-LYMPHOCYTE RATIOS; OXIDATIVE STRESS; MOOD DISORDERS; DIAGNOSTIC
   CONSISTENCY; NEUTROPHIL-LYMPHOCYTE; CEREBROSPINAL-FLUID; METABOLIC
   SYNDROME; URIC-ACID; WOMEN; TRANSTHYRETIN
AB Objectives: Conventional biochemical indexes may have predictive values in clinical identification between bipolar disorder (BD) and major depressive disorder (MDD). Methods: This study included 2,470 (BD/MDD = 1,333/1,137) hospitalized patients in Shanghai as training sets and 2,143 (BD/MDD = 955/1,188) in Hangzhou as test sets. A total of 35 clinical biochemical indexes were tested, including blood cells, immuno-inflammatory factors, liver enzymes, glycemic and lipid parameters, and thyroid and gonadal hormones. A stepwise analysis of a multivariable logistic regression was performed to build a predictive model to identify BD and MDD. Results: Most of these biochemical indexes showed significant differences between BD and MDD groups, such as white blood cell (WBC) in the hematopoietic system, uric acid (UA) in immuno-inflammatory factors, direct bilirubin (DBIL) in liver function, lactic dehydrogenase (LDH) in enzymes, and fasting blood glucose (FBG) and low-density lipoprotein (LDL) in glucolipid metabolism (p-values < 0.05). With these predictors for discrimination, we observed the area under the curve (AUC) of the predictive model to distinguish between BD and MDD to be 0.772 among men and 0.793 among women, with the largest AUC of 0.848 in the luteal phase of women. The chi(2) values of internal and external validation for male and female datasets were 2.651/10.264 and 10.873/6.822 (p-values < 0.05), respectively. The AUCs of the test sets were 0.696 for males and 0.707 for females. Conclusion: Discrimination and calibration were satisfactory, with fair-to-good diagnostic accuracy and external calibration capability in the final prediction models. Female patients may have a higher differentiability with a conventional biochemical index than male patients.
C1 [Zhu, Yuncheng; Wang, Zuowei] Shanghai Hongkou Mental Hlth Ctr, Div Mood Disorders, Shanghai, Peoples R China.
   [Zhu, Yuncheng; Niu, Zhiang; Liu, Hongmei; Wu, Xiaohui; Yang, Lu; Chen, Jun; Fang, Yiru] Shanghai Jiao Tong Univ Sch Med, Clin Res Ctr, Shanghai Mental Hlth Ctr, Shanghai, Peoples R China.
   [Ji, Haifeng] Shanghai Changning Mental Hlth Ctr, Div Psychiat, Shanghai, Peoples R China.
   [Fang, Yiru] CAS Ctr Excellence Brain Sci & Intelligence Techno, Shanghai, Peoples R China.
   [Fang, Yiru] Shanghai Key Lab Psychot Disorders, Shanghai, Peoples R China.
   [Zhu, Yuncheng; Niu, Zhiang; Liu, Hongmei; Wu, Xiaohui; Yang, Lu; Chen, Jun] Shanghai Jiao Tong Univ Sch Med, Shanghai Mental Hlth Ctr, Div Mood Disorders, Shanghai, Peoples R China.
C3 Shanghai Jiao Tong University; Shanghai Jiao Tong University
RP Fang, YR (corresponding author), Shanghai Jiao Tong Univ Sch Med, Clin Res Ctr, Shanghai Mental Hlth Ctr, Shanghai, Peoples R China.; Fang, YR (corresponding author), CAS Ctr Excellence Brain Sci & Intelligence Techno, Shanghai, Peoples R China.; Fang, YR (corresponding author), Shanghai Key Lab Psychot Disorders, Shanghai, Peoples R China.
EM yirufang@aliyun.com
RI Wang, Zuowei/AAT-8116-2020; WU, XIAOHUI/NHO-8747-2025
OI Wang, Zuowei/0000-0002-1929-231X
FU National Key R&D Program of China [2016YFC1307100]; National Natural
   Science Foundation of China [91232719, 81930033]; Scientific Research
   Project of Hongkou District Health Commission [2101-03]; Shanghai Key
   Medicine Specialties Program [ZK2019A06]; Shanghai Clinical Research
   Center for Mental Health (SCRC-MH) [19MC1911100]; Shanghai Mental Health
   Center Clinical Research Center Special Project for Big Data Analysis
   [CRC2018DSJ01-1]; Scientific Research Project of Shanghai Municipal
   Health Commission [202040318]; Key Project of Clinical Research Center
   of Shanghai Mental Health Center [CRC2018ZD02]; Innovative Research Team
   of High-level Local Universities in Shanghai
FX This study was supported by the National Key R & D Program of China
   (2016YFC1307100), the National Natural Science Foundation of China
   (91232719 and 81930033), the Scientific Research Project of Hongkou
   District Health Commission (2101-03), Shanghai Key Medicine Specialties
   Program (ZK2019A06), Shanghai Clinical Research Center for Mental Health
   (SCRC-MH, 19MC1911100), Shanghai Mental Health Center Clinical Research
   Center Special Project for Big Data Analysis (CRC2018DSJ01-1), the
   Scientific Research Project of Shanghai Municipal Health Commission
   (202040318), the Key Project of Clinical Research Center of Shanghai
   Mental Health Center (CRC2018ZD02), and also supported by the Innovative
   Research Team of High-level Local Universities in Shanghai.
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NR 60
TC 6
Z9 7
U1 2
U2 17
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-0640
J9 FRONT PSYCHIATRY
JI Front. Psychiatry
PD JUN 20
PY 2022
VL 13
AR 875141
DI 10.3389/fpsyt.2022.875141
PG 13
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 2Q1CS
UT WOS:000820166300001
PM 35795028
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Nilsson, A
   Cano, A
   Bergens, O
   Kadi, F
AF Nilsson, Andreas
   Cano, Antonio
   Bergens, Oscar
   Kadi, Fawzi
TI Randomized Controlled Trial for Promotion of Healthy Eating in Older
   Adults by Increasing Consumption of Plant-Based Foods: Effect on
   Inflammatory Biomarkers
SO NUTRIENTS
LA English
DT Article
DE fruit and vegetables; inflammation; diet; nutrition; physical activity;
   aging; TRANCE; TRAIL; CX3CL1
ID C-REACTIVE PROTEIN; VEGETABLE CONSUMPTION; FREQUENCY QUESTIONNAIRE;
   INCREASED FRUIT; DIETARY-INTAKE; METABOLIC SYNDROME; OXIDATIVE STRESS;
   RISK; INTERVENTION; METAANALYSIS
AB To what extent the intake of fruit and vegetables (FV) influences inflammatory status remains elusive, particularly in older populations. The aim of the present study was to determine the effect of increased FV intake for 16 weeks on circulating biomarkers of inflammation in a population of older men and women. Sixty-six participants (65-70 years) randomly assigned to either FV or control (CON) groups were instructed to increase FV intake to five servings per day through nutritional counseling (FV) or to maintain habitual diet (CON). Dietary intake and physical activity level (PA) were determined using food frequency questionnaire and accelerometers, respectively, at the start and end of the intervention. C-reactive protein (CRP), interleukin 6 (IL-6), IL-18, macrophage inflammatory protein-1 alpha (MIP-1 alpha), MIP-1 beta, tumor necrosis factor-alpha (TNF-alpha), TNF-related apoptosis-inducing ligand (TRAIL), TNF-related activation-induced cytokine (TRANCE), and C-X3-C motif chemokine ligand-1 (CX3CL1, or fractalkine) were analyzed. The FV group significantly increased daily FV intake (from 2.2 & PLUSMN; 1.3 to 4.2 & PLUSMN; 1.8 servings/day), with no change in CON. Waist circumference and PA level were unchanged by the intervention. Interaction effects (time x group, p < 0.05) for TRAIL, TRANCE, and CX3CL1 denoting a significant decrease (p < 0.05) in FV but not in CON were observed. No corresponding effects on CRP, IL6, TNF-alpha, MIP-1 alpha, and beta and IL-18 were observed. The present study demonstrates the influence of increased FV consumption on levels of some inflammatory biomarkers in a population of older adults. Future work is warranted to examine the clinical implications of FV-induced alterations in these inflammatory biomarkers.
C1 [Nilsson, Andreas; Bergens, Oscar; Kadi, Fawzi] Orebro Univ, Sch Hlth Sci, S-70182 Orebro, Sweden.
   [Cano, Antonio] Hosp Clin Univ INCLIVA, Serv Obstet & Gynecol, Valencia 46010, Spain.
   [Cano, Antonio] Univ Valencia, Dept Pediat Obstet & Gynecol, Valencia 46010, Spain.
C3 Orebro University; University of Valencia
RP Nilsson, A (corresponding author), Orebro Univ, Sch Hlth Sci, S-70182 Orebro, Sweden.
EM andreas.nilsson@oru.se; antonio.cano@uv.es; oscar.bergens@oru.se;
   fawzi.kadi@oru.se
RI Kadi, Fawzi/LDV-8063-2024; Nilsson, Andreas/LKK-3146-2024
OI Nilsson, Andreas/0000-0003-3793-335X; Cano, Antonio/0000-0001-8046-0303;
   kadi, fawzi/0000-0002-9831-0896; Bergens, Oscar/0000-0002-1767-9297
FU EU [727565]
FX This research was funded by the EU HORIZON 2020 Research and Innovation
   Program (European Joint Programming Initiative "A healthy diet for a
   healthy life" "JPI HDHL" and the ERA-NET co-fund HDHL-INTIMIC), GA no.
   727565.
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NR 41
TC 8
Z9 9
U1 2
U2 11
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD NOV
PY 2021
VL 13
IS 11
AR 3753
DI 10.3390/nu13113753
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA XI6QZ
UT WOS:000726234800001
PM 34836009
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Duc, HN
   Oh, H
   Kim, MS
AF Duc, Hai Nguyen
   Oh, Hojin
   Kim, Min-Sun
TI The Effect of Mixture of Heavy Metals on Obesity in Individuals ≥50
   Years of Age
SO BIOLOGICAL TRACE ELEMENT RESEARCH
LA English
DT Article
DE Obesity; Mercury; Heavy metals; Chemical mixture
ID BLOOD MERCURY LEVELS; EXAMINATION SURVEY KNHANES; KOREAN
   NATIONAL-HEALTH; METABOLIC SYNDROME; OXIDATIVE STRESS; BODY-COMPOSITION;
   ASSOCIATION; CADMIUM; EXPOSURE; ADULTS
AB Little is known about the association between a mixture of heavy metals and obesity among individuals >= 50 years of age with comorbidities. Thus, we identified the associations of serum cadmium (Cd), lead (Pb), and mercury (Hg) with obesity using linear regression models; weighted quantile sum (WQS) regression, quantile g-computation (qgcomp), and Bayesian kernel machine regression (BKMR) were conducted as secondary analyses. Of the 6434 subjects included in the analysis, 13.8% had obesity and 44.6% had abdominal obesity. In the logistic regression model, serum Hg was associated with obesity and abdominal obesity, and significant trends were observed for these heavy metal tertiles (p < 0.001). Serum Hg levels were also associated with body mass index (BMI) and waist circumference (WC). The WQS index was significantly associated with both obesity (OR = 1.43, 95% CI: 1.40-1.46) and abdominal obesity (beta = 1.51, 95% CI: 1.48-1.54). The qgcomp index also found a significant association between heavy metals and both obesity (OR = 1.35, 95% CI: 1.12-1.63) and abdominal obesity (OR = 1.34, 95% CI: 1.12-1.60). Serum Hg was the most heavily weighed heavy metal in these models. In BKMR analysis, the overall effect of the mixture was significantly associated with obesity, BMI, and WC. Serum Hg showed positive trends and was observed as the most important factor associated with obesity, BMI, and WC. Our findings were largely robust to secondary analyses that used three novel mixture modeling approaches: WQS, qpcomp, and BKMR. Given increasing exposure to heavy metals, well-characterized cohorts of individuals aged >= 50 years are required to determine the mixed effects of heavy metals on obesity and related diseases.
C1 [Duc, Hai Nguyen; Oh, Hojin; Kim, Min-Sun] Sunchon Natl Univ, Coll Pharm, Dept Pharm, Sunchon, Jeonnam, South Korea.
   [Duc, Hai Nguyen; Oh, Hojin; Kim, Min-Sun] Sunchon Natl Univ, Res Inst Life & Pharmaceut Sci, Dept Pharm, Sunchon, Jeonnam, South Korea.
C3 Sunchon National University; Sunchon National University
RP Kim, MS (corresponding author), Sunchon Natl Univ, Coll Pharm, Dept Pharm, Sunchon, Jeonnam, South Korea.; Kim, MS (corresponding author), Sunchon Natl Univ, Res Inst Life & Pharmaceut Sci, Dept Pharm, Sunchon, Jeonnam, South Korea.
EM minsun@scnu.ac.kr
RI Oh, Hojin/ABA-7781-2021; Nguyen Duc, Hai/AAD-8210-2020
OI Oh, Hojin/0000-0002-4022-5998; Nguyen Duc, Hai/0000-0001-8419-7784; Kim,
   Min-Sun/0000-0001-9952-0038
FU National Research Foundation of Korea (NRF) - Korea government (MEST)
   [NRF2013R1A1A3008851, 2018R1D1A1B07049610]
FX This work was supported by the National Research Foundation of Korea
   (NRF) grant funded by the Korea government (MEST) (grant nos.
   NRF2013R1A1A3008851 and 2018R1D1A1B07049610).
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NR 70
TC 56
Z9 59
U1 11
U2 52
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0163-4984
EI 1559-0720
J9 BIOL TRACE ELEM RES
JI Biol. Trace Elem. Res.
PD AUG
PY 2022
VL 200
IS 8
BP 3554
EP 3571
DI 10.1007/s12011-021-02972-z
EA OCT 2021
PG 18
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 2I2GS
UT WOS:000710351700001
PM 34686995
DA 2025-06-11
ER

PT J
AU Naserizadeh, SK
   Taherifard, MH
   Shekari, M
   Mesrkanlou, HA
   Asbaghi, O
   Nazarian, B
   Khosroshahi, MZ
   Heydarpour, F
AF Naserizadeh, Seyed Kasra
   Taherifard, Mohammad Hassan
   Shekari, Mandi
   Mesrkanlou, Hossein Amarpoor
   Asbaghi, Omid
   Nazarian, Behzad
   Khosroshahi, Mohammad Zeinali
   Heydarpour, Fatemeh
TI The effect of crocin supplementation on lipid concentrations and fasting
   blood glucose: A systematic review and meta-analysis and meta-regression
   of randomized controlled trials
SO COMPLEMENTARY THERAPIES IN MEDICINE
LA English
DT Review
DE Crocin; Lipid profile; Fasting blood glucose; Meta-analysis;
   Meta-regression
ID METABOLIC SYNDROME; SAFETY EVALUATION; SATIVUS L.; ANTIOXIDANT ACTIVITY;
   OXIDATIVE STRESS; SAFFRON EXTRACT; AQUEOUS EXTRACT; SERUM-LIPIDS;
   PROFILE; PLASMA
AB Objective: This meta-analysis aimed to assess the effects of crocin supplementation on fasting blood glucose (FBG) and lipid profile levels in clinical trial studies.
   Design: A systematic literature search was performed in PubMed, Scopus, Embase, Web of Science, and the Cochrane Library databases for clinical trials published from the beginning up to November 2019. Of the 547 papers identified from all searched databases, eight eligible studies with nine effect sizes have all needed criteria for inclusion in this meta-analysis.
   Results: Results of the pooled random-effect size analysis showed just a significant decreasing effect of crocin supplementation on FBG (WMD: -6.52 mg/l, 95 % CI, -11.96, -1.08; p = 0.019) and TC (WMD: -4.64 mg/l, 95 % CI, -8.19, -1.09; p = 0.010). Crocin supplements did not have any significant effect on serum TG (p = 0.144) levels, LDL-C (p = 0.161), and HDL-C (p = 0.872) levels. Results showed that crocin supplementation could beneficially have effect on TG level only when trial duration less than 12 weeks and LDL-C levels in trials that used high dose intervention and trials that conducted on subjects with metabolic disorders. However, crocin supplementation did not significantly change FBG in trials that used low dose intervention. Meta-regression analysis indicated a linear relationship between the duration of intervention and significant change in FBG (p = 0.019).
   Conclusion: Results of this systematic review and meta-analysis study have shown that crocin supplementation can decrease significantly FBS and TC without any beneficial effects on TG, LDL-C, and HDL-C levels.
C1 [Naserizadeh, Seyed Kasra] Univ Tehran Med Sci, Tehran, Iran.
   [Taherifard, Mohammad Hassan] Islamic Azad Univ, East Tehran Branch, Dept Phys Educ, Tehran, Iran.
   [Shekari, Mandi] Qazvin Univ Med Sci Qazvin, Fac Hlth, Dept Nutr, Qazvin, Iran.
   [Mesrkanlou, Hossein Amarpoor] Tabriz Univ Med Sci, Fac Publ Hlth & Nutr, Tabriz, Iran.
   [Asbaghi, Omid; Nazarian, Behzad; Khosroshahi, Mohammad Zeinali] Lorestan Univ Med Sci, Student Res Comm, Khorramabad, Iran.
   [Heydarpour, Fatemeh] Kermanshah Univ Med Sci, Social Dev & Hlth Promot Res Ctr, Hlth Inst, Kermanshah, Iran.
C3 Tehran University of Medical Sciences; Islamic Azad University; Qazvin
   University of Medical Sciences (QUMS); Tabriz University of Medical
   Science; Lorestan University of Medical Sciences; Kermanshah University
   of Medical Sciences
RP Heydarpour, F (corresponding author), Kermanshah Univ Med Sci, Social Dev & Hlth Promot Res Ctr, Hlth Inst, Kermanshah, Iran.
EM Drnaseri.k@gmail.com; mohammad.taherifard@yahoo.com;
   Mehdishekari025@gmail.com; h_amarpoor@yahoo.com; omid.asbaghi@gmail.com;
   nazarianbehzad969@yahoo.com; mz.med.edu@gmail.com;
   fa.heidarpour@kums.ac.ir
RI Heydarpour, Fatemeh/S-9380-2017
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NR 46
TC 15
Z9 15
U1 0
U2 5
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0965-2299
EI 1873-6963
J9 COMPLEMENT THER MED
JI Complement. Ther. Med.
PD AUG
PY 2020
VL 52
AR 102500
DI 10.1016/j.ctim.2020.102500
PG 9
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA OA1IW
UT WOS:000577549300053
PM 32951748
DA 2025-06-11
ER

PT J
AU Hackler, E III
   Lew, J
   Gore, MO
   Ayers, CR
   Atzler, D
   Khera, A
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   Neeland, I
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   de Lemos, JA
AF Hackler, Eddie, III
   Lew, Jeanney
   Gore, M. Odette
   Ayers, Colby R.
   Atzler, Dorothee
   Khera, Amit
   Rohatgi, Anand
   Lewis, Alana
   Neeland, Ian
   Omland, Torbjorn
   de Lemos, James A.
TI Racial Differences in Cardiovascular Biomarkers in the General
   Population
SO JOURNAL OF THE AMERICAN HEART ASSOCIATION
LA English
DT Article
DE biomarker; endothelial dysfunction; inflammation
ID LEFT-VENTRICULAR STRUCTURE; DISEASE RISK; CORONARY ATHEROSCLEROSIS;
   SOCIOECONOMIC-STATUS; NATRIURETIC PEPTIDE; METABOLIC SYNDROME; SOLUBLE
   RECEPTOR; PLASMA-LEVELS; ALL-CAUSE; HEART
AB Background-The incidence and clinical manifestations of cardiovascular disease (CVD) differ between blacks and whites. Biomarkers that reflect important pathophysiological pathways may provide a window to allow deeper understanding of racial differences in CVD.
   Methods and Results-The study included 2635 white and black participants from the Dallas Heart Study who were free from existing CVD. Cross-sectional associations between race and 32 biomarkers were evaluated using multivariable linear regression adjusting for age, traditional CVD risk factors, imaging measures of body composition, renal function, insulin resistance, left ventricular mass, and socioeconomic factors. In fully adjusted models, black women had higher lipoprotein(a), leptin, D-dimer, osteoprotegerin, antinuclear antibody, homoarginine, suppression of tumorigenicity-2, and urinary microalbumin, and lower adiponectin, soluble receptor for advanced glycation end products and N-terminal pro-B-type natriuretic peptide versus white women. Black men had higher lipoprotein(a), leptin, D-dimer, high-sensitivity C-reactive protein, antinuclear antibody, symmetrical dimethylarginine, homoarginine, high-sensitivity cardiac troponin T, suppression of tumorigenicity-2, and lower adiponectin, soluble receptor for advanced glycation end products, and N-terminal pro-B-type natriuretic peptide versus white men. Adjustment for biomarkers that were associated with higher CVD risk, and that differed between blacks and whites, attenuated the risk for CVD events in black women (unadjusted hazard ratio 2.05, 95% CI 1.32, 3.17 and adjusted hazard ratio 1.15, 95% CI 0.69, 1.92) and black men (unadjusted hazard ratio 2.39, 95% CI 1.64, 3.46, and adjusted hazard ratio 1.21, 95% CI 0.76, 1.95).
   Conclusions-Significant racial differences were seen in biomarkers reflecting lipids, adipokines, and biomarkers of endothelial function, inflammation, myocyte injury, and neurohormonal stress, which may contribute to racial differences in the development and complications of CVD.
C1 [Hackler, Eddie, III; Ayers, Colby R.; Khera, Amit; Rohatgi, Anand; Lewis, Alana; Neeland, Ian; de Lemos, James A.] UT Southwestern Med Ctr, Dept Med, Dallas, TX USA.
   [Ayers, Colby R.] UT Southwestern Med Ctr, Dept Clin Sci, Dallas, TX USA.
   [Lew, Jeanney] Baylor St Lukes Med Ctr, Dept Cardiovasc Dis, Houston, TX USA.
   [Gore, M. Odette] Univ Colorado, Dept Med, Anschutz Med Campus, Denver, CO USA.
   [Gore, M. Odette] Denver Hlth & Hosp Author, Denver, CO USA.
   [Atzler, Dorothee] Ludwig Maximilians Univ Munchen, Inst Cardiovasc Prevent, Munich, Germany.
   [Omland, Torbjorn] Akershus Univ Hosp, Dept Med, Lorenskog, Norway.
   [Omland, Torbjorn] Univ Oslo, Oslo, Norway.
C3 University of Texas System; University of Texas Southwestern Medical
   Center Dallas; University of Texas System; University of Texas
   Southwestern Medical Center Dallas; University of Colorado System;
   University of Colorado Denver; University of Colorado Anschutz Medical
   Campus; Denver Health Medical Center; University of Munich; University
   of Oslo; University of Oslo
RP de Lemos, JA (corresponding author), 5909 Harry Hines Blvd E 5-7528, Dallas, TX 75390 USA.
EM james.delemos@utsouthwestern.edu
RI Atzler, Dorothee/ACA-4345-2022; de Lemos, James/ABD-6669-2021
OI Atzler, Dorothee/0000-0002-6551-1544
FU Donald W. Reynolds Foundation; National Center for Advancing
   Translational Sciences of the NIH [UL1TR001105]; Roche Diagnostics;
   Alere, Inc; LipoScience; Siemens Healthcare Diagnostics, Inc.; National
   Institute of Diabetes and Digestive and Kidney Diseases of the National
   Institute of Health [1K23DK106520]; Dedman Family Scholarship in
   Clinical Care from UT Southwestern; European Union under a Marie Curie
   Intra-European Fellowship for Career Development; National Heart, Lung,
   and Blood Institute of the NIH [K08HL118131]; American Heart Association
   [15CVGPSD27030013]; American Heart Association (AHA) [15CVGPSD27030013]
   Funding Source: American Heart Association (AHA)
FX The Dallas Heart Study has been supported by grants from the Donald W.
   Reynolds Foundation and the National Center for Advancing Translational
   Sciences of the NIH (UL1TR001105). Biomarker measurements for the
   present study were supported by Roche Diagnostics, Alere, Inc,
   LipoScience, and Siemens Healthcare Diagnostics, Inc. Funding support
   for Dr Neeland is provided by grant 1K23DK106520 from the National
   Institute of Diabetes and Digestive and Kidney Diseases of the National
   Institute of Health and by the Dedman Family Scholarship in Clinical
   Care from UT Southwestern. Dr Atzler acknowledges the support of the
   European Union under a Marie Curie Intra-European Fellowship for Career
   Development. Dr Rohatgi is supported by the National Heart, Lung, and
   Blood Institute of the NIH under Award Number K08HL118131 and by the
   American Heart Association under Award Number 15CVGPSD27030013.
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NR 64
TC 72
Z9 76
U1 0
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
EI 2047-9980
J9 J AM HEART ASSOC
JI J. Am. Heart Assoc.
PD SEP 17
PY 2019
VL 8
IS 18
AR e012729
DI 10.1161/JAHA.119.012729
PG 16
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA JJ0EU
UT WOS:000493836300021
PM 31514563
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Rafiei, H
   Robinson, E
   Barry, J
   Jung, ME
   Little, JP
AF Rafiei, Hossein
   Robinson, Emily
   Barry, Julianne
   Jung, Mary Elizabeth
   Little, Jonathan Peter
TI Short-term exercise training reduces glycaemic variability and lowers
   circulating endothelial microparticles in overweight and obese women at
   elevated risk of type 2 diabetes
SO EUROPEAN JOURNAL OF SPORT SCIENCE
LA English
DT Article
DE High-intensity interval training; moderate-intensity continuous
   training; glycaemic variability; continuous glucose monitoring;
   endothelial microparticles
ID HIGH-INTENSITY INTERVAL; OXIDATIVE STRESS; INSULIN SENSITIVITY;
   METABOLIC SYNDROME; MODERATE EXERCISE; GLUCOSE-UPTAKE; SINGLE BOUT;
   HYPERGLYCEMIA; INTERMITTENT; ACTIVATION
AB Exercise is recognized as a frontline therapy for the prevention and treatment of type 2 diabetes (T2D) but the optimal type of exercise is not yet determined. We compared the effects of high-intensity interval training (HIIT) with moderate-intensity continuous training (MICT) for improvement of continuous glucose monitoring (CGM)-derived markers of glycaemic variability, and biomarkers of endothelial cell damage (CD31+ and CD62+ endothelial microparticles (EMPs)) within a population at elevated risk of developing T2D. Fifteen inactive overweight or obese women were randomized to 2 weeks (10-sessions) of progressive HIIT (n=8, 4-10X 1-min @ similar to 90% peak heart rate, 1-min rest periods) or MICT (n=7, 20-50min of continuous activity at similar to 65% peak heart rate). Prior and three days post-training, fasting blood samples were collected. Both HIIT and MICT improved glycaemic variability as measured by CGM standard deviation (HIIT: 0.82 +/- 0.39 vs. 0.72 +/- 0.33mmol/L; MICT: 0.82 +/- 0.19 vs. 0.62 +/- 0.16mmol/L, pre vs. post) and mean amplitude of glycaemic excursions (MAGE; HIIT: 1.98 +/- 0.81 vs. 1.41 +/- 0.90; MICT; 1.98 +/- 0.43 vs. 1.65 +/- 0.48, pre vs. post) with no difference between groups. CD62+ EMPs were lower following HIIT (187.7 +/- 65 vs. 174.9 +/- 55, pre vs. post) and MICT (170 +/- 60 vs. 160.3 +/- 59, pre vs. post) with no difference between groups. There was no change in 24-h mean glucose or CD31+ EMPs. Two weeks of both HIIT or MICT similarly decreased glycaemic variability and CD62+ EMPs in overweight/obese women at elevated risk of T2D.
C1 [Rafiei, Hossein; Robinson, Emily; Barry, Julianne; Jung, Mary Elizabeth; Little, Jonathan Peter] Univ British Columbia, Sch Hlth & Exercise Sci, Fac Hlth & Social Dev, Okanagan Campus,3333 Univ Way, Kelowna, BC V1V 1V7, Canada.
C3 University of British Columbia
RP Little, JP (corresponding author), Univ British Columbia, Sch Hlth & Exercise Sci, Fac Hlth & Social Dev, Okanagan Campus,3333 Univ Way, Kelowna, BC V1V 1V7, Canada.
EM jonathan.little@ubc.ca
RI Little, Jonathan/T-4076-2019; Rafiei, Hossein/W-4825-2017
OI Rafiei, Hossein/0000-0002-4843-9261; Little,
   Jonathan/0000-0002-9796-2008
FU Canadian Institutes of Health Research (CIHR) [133581]; Michael Smith
   Foundation for Health Research (MSFHR) Scholar Award [5917]; CIHR New
   Investigator Award [MSH-141980]; MSFHR Scholar Award [16890]; Medtronic
   Diabetes through an Investigator-Initiated Research Support Grant
FX This project was funded by the Canadian Institutes of Health Research
   (CIHR) grant (133581) to MEJ and JPL. Continuous glucose monitors and
   sensors were provided in-kind from Medtronic Diabetes through an
   Investigator-Initiated Research Support Grant to JPL. MEJ is supported
   by a Michael Smith Foundation for Health Research (MSFHR) Scholar Award
   (Award 5917). JPL is supported by a CIHR New Investigator Award
   (MSH-141980) and MSFHR Scholar Award (16890).
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NR 44
TC 15
Z9 17
U1 1
U2 28
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1746-1391
EI 1536-7290
J9 EUR J SPORT SCI
JI Eur. J. Sport Sci.
PD SEP 14
PY 2019
VL 19
IS 8
BP 1140
EP 1149
DI 10.1080/17461391.2019.1576772
PG 10
WC Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Sport Sciences
GA IM1MR
UT WOS:000477754700014
PM 30776253
DA 2025-06-11
ER

PT J
AU Tepedelen, BE
   Soya, E
   Korkmaz, M
AF Tepedelen, Burcu Erbaykent
   Soya, Elif
   Korkmaz, Mehmet
TI Epigallocatechin-3-gallate reduces the proliferation of benign prostatic
   hyperplasia cells via regulation of focal adhesions
SO LIFE SCIENCES
LA English
DT Article
DE EGCG; BPH; Cytoskeleton; F-Actin; FAK; Paxillin
ID GREEN-TEA; EPITHELIAL-CELLS; METABOLIC SYNDROME; GROWTH-FACTOR; CANCER
   RISK; EXPRESSION; MIGRATION; KINASE; INHIBITION; APOPTOSIS
AB Aims: Benign prostatic hyperplasia (BPH) is the most common urological disease that is characterized by the excessive growth of prostatic epithelial and stromal cells. Pharmacological therapy for BPH has limited use due to the many side effects so there is a need for new agents including natural compounds such as epigallocatechin-3-gallate (EGCG). This study was undertaken to assess the role of EGCG, suppressing the formation of BPH by reducing inflammation and oxidative stress, in cytoskeleton organization and ECM interactions via focal adhesions.
   Main methods: We performed MTT assay to investigate cell viability of BPH-1 cells, wound healing assay to examine cell migration, immunofluorescence assay for F-actin organization and paxillin distribution and finally immunoblotting to investigate focal adhesion protein levels in the presence and absence of EGCG.
   Key findings: We found that EGCG inhibits cell proliferation at the concentration of 89.12 mu M, 21.2 mu M and 2.39 mu M for 24, 48 and 72 h, respectively as well as inhibitory effects of EGCG on BPH-1 cell migration were observed in a wound healing assay. Furthermore, it was determined by immunofluorescence labeling that EGCG disrupts F-actin organization and reduces paxillin distribution. Additionally, EGCG decreases the activation of FAK (Focal Adhesion Kinase) and the levels of paxillin, RhoA (Ras homolog gene family, member A), Cdc42 (cell division cycle 42) and PAK1 (p21 protein-activated kinase 1) in a dose-dependent manner.
   Significance: For the first time, by this study, we found evidence that BPH-1 cell proliferation could be inhibited with EGCG through the disruption of cytoskeleton organization and ECM interactions. Consequently, EGCG might be useful in the prevention and treatment of diseases characterized by excessive cell proliferation such as BPH.
C1 [Tepedelen, Burcu Erbaykent] Uludag Univ, Fac Arts & Sci, Dept Mol Biol & Genet, TR-16059 Bursa, Turkey.
   [Soya, Elif; Korkmaz, Mehmet] Manisa Celal Bayar Univ, Dept Med Biol, Fac Med, TR-45030 Manisa, Turkey.
C3 Uludag University; Celal Bayar University
RP Korkmaz, M (corresponding author), Manisa Celal Bayar Univ, Dept Med Biol, Fac Med, TR-45030 Manisa, Turkey.
EM mehmet.korkmaz@cbu.edu.tr
RI Soya, Elif/AGE-9174-2022; Korkmaz, Mehmet/N-8168-2015; Tepedelen,
   Burcu/AAH-6436-2021
OI Korkmaz, Mehmet/0000-0003-1058-5586; Soya, Elif/0000-0002-7956-1315
FU Turkish Scientific and Technological Research Council [TUBITAK 113S700]
FX This research was supported with grants [TUBITAK 113S700] from the
   Turkish Scientific and Technological Research Council.
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NR 60
TC 16
Z9 16
U1 0
U2 48
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0024-3205
EI 1879-0631
J9 LIFE SCI
JI Life Sci.
PD DEC 15
PY 2017
VL 191
BP 74
EP 81
DI 10.1016/j.lfs.2017.10.016
PG 8
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA FL6SM
UT WOS:000414376500010
PM 29032114
DA 2025-06-11
ER

PT J
AU Kim, IH
   Nam, TJ
AF Kim, In-Hye
   Nam, Taek-Jeong
TI Enzyme-treated Ecklonia cava extract inhibits adipogenesis
   through the downregulation of C/EBPα in 3T3-L1 adipocytes
SO INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
LA English
DT Article
DE Ecklonia cava; enzyme; adipogenesis; 3T3-L1 adipocytes
ID MITOTIC CLONAL EXPANSION; HIGH-FAT DIET; EDIBLE BROWN-ALGAE; METABOLIC
   SYNDROME; OXIDATIVE STRESS; BINDING-PROTEIN; CANCER CELLS;
   CARDIOVASCULAR-DISEASE; ANTIOXIDANT PROPERTIES; UNDARIA-PINNATIFIDA
AB In this study, we examined the inhibitory effects of enzyme- treated Ecklonia cava (EEc) extract on the adipogenesis of 3T3-L1 adipocytes. The components of Ecklonia cava (E. cava) were first separated and purified using the digestive enzymes pectinase (Rapidase (R) X-Press L) and cellulase (Rohament (R) CL). We found that the EEc extract contained three distinct phlorotannins: eckol, dieckol and phlorofucofuroeckol-A. Among the phlorotannins, dieckol was the most abundant in the EEc extract at 16 mg/g. Then we examined the inhibitory effects of EEc extract treatment on differentiation-related transcription factors and on adipogenesis-related gene expression in vitro using 3T3-L1 adipocytes. 3T3-L1 pre-adipocytes were used to determine the concentrations of the EEc extract and Garcinia cambogia (Gar) extract that did not result in cytotoxicity. Glucose utilization and triglyceride (TG) accumulation in the EEc-treated adipocytes were similarly inhibited by 50 mu g/ml EEc and 200 mu g/ml Gar, and these results were confirmed by Oil Red 0 staining. Protein expression of adipogenesis differentiation-related transcription factors following treatment with the EEc extract was also examined. Only the expression of CCAAT/enhancer-binding protein (C/EBP)a was decreased, while there was no effect on the expression of C/EBP beta, C/EBP delta, and peroxisome proliferator-activated receptor gamma (PPAR gamma). Treatment with the EEc extract decreased the expression levels of adipogenesis-related genes, in particular sterol regulatory element binding protein-1c (SREBP-1c), adipocyte fatty acid binding protein (A-FABP), fatty acid synthase (FAS) and adiponectin. These results suggest that EEc extract treatment has an inhibitory effect on adipogenesis, specifically by affecting the activation of the C/EBP alpha signaling pathway and the resulting adipogenesis-related gene expression.
C1 [Kim, In-Hye; Nam, Taek-Jeong] Pukyong Natl Univ, Inst Fisheries Sci, Busan 619911, South Korea.
   [Nam, Taek-Jeong] Pukyong Natl Univ, Dept Food & Life Sci, 45 Yongso Ro, Busan 608737, South Korea.
C3 Pukyong National University; Pukyong National University
RP Nam, TJ (corresponding author), Pukyong Natl Univ, Dept Food & Life Sci, 45 Yongso Ro, Busan 608737, South Korea.
EM namtj@pknu.ac.kr
RI Kim, Eun/AAS-6706-2020
FU Fishery Commercialization Technology Development Program through iPET
   (Korea Institute of Planning and Evaluation for Technology in Food,
   Agriculture, Forestry and Fisheries) - Ministry of Oceans and Fisheries
   (MOF) [111090-03-3-HD110]; Basic Science Research Program through the
   National Research Foundation of Korea - Ministry of Education
   [2012R1A6A1028677]
FX This study was supported by the Fishery Commercialization Technology
   Development Program through iPET (Korea Institute of Planning and
   Evaluation for Technology in Food, Agriculture, Forestry and Fisheries)
   funded by the Ministry of Oceans and Fisheries (MOF) (no.
   111090-03-3-HD110). In addition, this study was supported by the Basic
   Science Research Program through the National Research Foundation of
   Korea funded by the Ministry of Education (grant no. 2012R1A6A1028677).
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NR 76
TC 24
Z9 25
U1 0
U2 17
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1107-3756
EI 1791-244X
J9 INT J MOL MED
JI Int. J. Mol. Med.
PD MAR
PY 2017
VL 39
IS 3
BP 636
EP 644
DI 10.3892/ijmm.2017.2869
PG 9
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA EP1VU
UT WOS:000397173200017
PM 28204815
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Calderón-Garcidueñas, L
   de la Monte, SM
AF Calderon-Garciduenas, Lilian
   de la Monte, Suzanne M.
TI Apolipoprotein E4, Gender, Body Mass Index, Inflammation, Insulin
   Resistance, and Air Pollution Interactions: Recipe for Alzheimer's
   Disease Development in Mexico City Young Females
SO JOURNAL OF ALZHEIMERS DISEASE
LA English
DT Review
DE APOE; Alzheimer's disease; body mass index; children; cognition;
   dementia; diabetes; female gender; glucose; insulin resistance; leptin;
   metabolic syndrome; Mexico City; nanoparticles; PM 2.5
ID MAGNETIC-RESONANCE-SPECTROSCOPY; INNATE IMMUNE-RESPONSE; WHITE-MATTER
   PATHOLOGY; APOE EPSILON-4 ALLELE; VITAMIN-D DEFICIENCY; SYSTEMIC
   INFLAMMATION; E POLYMORPHISM; TUMOR-SUPPRESSOR; SEX-DIFFERENCES;
   COGNITIVE IMPAIRMENT
AB Given the epidemiological trends of increasing Alzheimer's disease (AD) and growing evidence that exposure and lifestyle factors contribute to AD risk and pathogenesis, attention should be paid to variables such as air pollution, in order to reduce rates of cognitive decline and dementia. Exposure to fine particulate matter (PM2.5) and ozone (O-3) above the US EPA standards is associated with AD risk. Mexico City children experienced pre- and postnatal high exposures to PM2.5, O-3, combustion-derived iron-rich nanoparticles, metals, polycyclic aromatic hydrocarbons, and endotoxins. Exposures are associated with early brain gene imbalance in oxidative stress, inflammation, innate and adaptive immune responses, along with epigenetic changes, accumulation of misfolded proteins, cognitive deficits, and brain structural and metabolic changes. The Apolipoprotein E (APOE) 4 allele, the most prevalent genetic risk for AD, plays a key role in the response to air pollution in young girls. APOE 4 heterozygous females with >75% to <94% BMI percentiles are at the highest risk of severe cognitive deficits (1.5-2 SD from average IQ). This review focused on the relationships between gender, BMI, systemic and neural inflammation, insulin resistance, hyperleptinemia, dyslipidemia, vascular risk factors, and central nervous system involvement in APOE4 urbanites exposed to PM2.5 and magnetite combustion-derived iron-rich nanoparticles that can reach the brain. APOE4 young female heterozygous carriers constitute a high-risk group for a fatal disease: AD. Multidisciplinary intervention strategies could be critical for prevention or amelioration of cognitive deficits and long-term AD progression in young individuals at high risk.
C1 [Calderon-Garciduenas, Lilian] Univ Montana, 32 Campus Dr,287 Skaggs Bldg, Missoula, MT 59812 USA.
   [Calderon-Garciduenas, Lilian] Univ Valle Mexico, Ciudad De Mexico, Mexico.
   [de la Monte, Suzanne M.] Brown Univ, Alpert Med Sch, Providence, RI 02912 USA.
C3 University of Montana System; University of Montana; Universidade del
   Valle de Mexico; Brown University
RP Calderón-Garcidueñas, L (corresponding author), Univ Montana, 32 Campus Dr,287 Skaggs Bldg, Missoula, MT 59812 USA.
EM lilian.calderon-garciduenas@umontana.edu
RI de la monte, suzanne/L-7670-2019
FU CONACYT [255956]; NIH [R01-AA-11431]
FX This work was partially supported by CONACYT # 255956 and R01-AA-11431
   from the NIH.
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NR 192
TC 39
Z9 41
U1 3
U2 57
PU IOS PRESS
PI AMSTERDAM
PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS
SN 1387-2877
EI 1875-8908
J9 J ALZHEIMERS DIS
JI J. Alzheimers Dis.
PY 2017
VL 58
IS 3
BP 613
EP 630
DI 10.3233/JAD-161299
PG 18
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA EX1PB
UT WOS:000402995800002
PM 28527212
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Huang, YC
   Lin, PY
   Lee, Y
   Wu, CC
   Hsu, ST
   Hung, CF
   Chen, CC
   Chong, MY
   Lin, CH
   Wang, LJ
AF Huang, Yu-Chi
   Lin, Pao-Yen
   Lee, Yu
   Wu, Chih-Ching
   Hsu, Su-Ting
   Hung, Chi-Fa
   Chen, Chien-Chih
   Chong, Mian-Yoon
   Lin, Chieh-Hsin
   Wang, Liang-Jen
TI β-hydroxybutyrate, pyruvate and metabolic profiles in patients with
   schizophrenia: A case control study
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE Metabolic syndrome; Glucose; Ketone body; Biomarker; Metabolite;
   Schizophrenia
ID NEGATIVE SYNDROME SCALE; DRUG-NAIVE; 2ND-GENERATION ANTIPSYCHOTICS;
   ATYPICAL ANTIPSYCHOTICS; AEROBIC GLYCOLYSIS; GLUCOSE-METABOLISM;
   ADIPONECTIN LEVELS; PERIPHERAL-BLOOD; BRAIN METABOLISM; OXIDATIVE STRESS
AB The disturbances of beta-hydroxybutyrate (beta-HB) and pyruvate are linked with impaired brain energy utilization which involves in the psychopathology of schizophrenia. This study investigates the difference in levels of beta-HB and pyruvate between patients with schizophrenia and healthy controls, and explores their relationship with metabolic profiles and disease characteristics. We recruited 54 physically-health schizophrenic patients and 54 age- and gender-matched healthy control subjects. Blood samples were gathered to determine the serum levels of beta-HB and pyruvate and plasma levels of metabolic profiles, including fasting glucose, triglycerides, total cholesterol, high- and low-density lipoprotein-cholesterol and adiponectin. The disease characteristics and psychopathology of patients with schizophrenia were assessed by using the Positive and Negative Syndrome Scale. Of patients with schizophrenia, serum levels of beta-HB were significantly correlated with fasting glucose (p = 0.007) and triglycerides (p = 0.021). Pyruvate was significantly correlated with fasting glucose (p = 0.018), total cholesterol (p = 0.005), triglycerides (p = 0.014) and LDL-C (p = 0.006). After controlling the metabolic profiles, beta-HB was still significantly higher in schizophrenia patients than in controls (p < 0.001), but no difference in pyruvate was observed. Neither beta-HB nor pyruvate was significantly correlated with disease characteristics. However, pyruvate was higher in patients treated with olanzapine or clozapine than in those treated with other antipsychotics (p = 0.048). Findings suggest that schizophrenic patients had significantly higher serum levels of beta-HB than control subjects, possibly reflecting higher demands in energy utilization. Serum levels of beta-HB, rather than pyruvate, may act as a potential indicator of energy utilization impairment for schizophrenia. (C) 2016 Elsevier Ltd. All rights reserved.
C1 [Huang, Yu-Chi; Lin, Pao-Yen; Lee, Yu; Hung, Chi-Fa; Chen, Chien-Chih; Chong, Mian-Yoon; Lin, Chieh-Hsin] Chang Gung Mem Hosp, Dept Psychiat, Kaohsiung, Taiwan.
   [Huang, Yu-Chi; Lin, Pao-Yen; Lee, Yu; Hung, Chi-Fa; Chen, Chien-Chih; Chong, Mian-Yoon; Lin, Chieh-Hsin; Wang, Liang-Jen] Chang Gung Univ, Coll Med, 123 Ta Pei Rd, Kaohsiung 83301, Taiwan.
   [Lin, Pao-Yen] Kaohsiung Chang Gung Mem Hosp, Inst Translat Res Biomed Sci, Kaohsiung, Taiwan.
   [Wu, Chih-Ching] Linkuo Chang Gung Mem Hosp, Dept Otolaryngol Head & Neck Surg, Taoyuan, Taiwan.
   [Wu, Chih-Ching] Chang Gung Univ, Dept Med Biotechnol & Lab Sci, Taoyuan, Taiwan.
   [Hsu, Su-Ting] Kaohsiung Municipal Kai Syuan Psychiat Hosp, Kaohsiung, Taiwan.
   [Wang, Liang-Jen] Kaohsiung Chang Gung Mem Hosp, Dept Child & Adolescent Psychiat, 123 Ta Pei Rd, Kaohsiung, Taiwan.
   [Wang, Liang-Jen] Chang Gung Univ, Coll Med, Dept Chinese Med, Taoyuan, Taiwan.
C3 Chang Gung Memorial Hospital; Chang Gung University; Chang Gung Memorial
   Hospital; Chang Gung University; Chang Gung Memorial Hospital; Chang
   Gung University
RP Wang, LJ (corresponding author), Chang Gung Univ, Coll Med, 123 Ta Pei Rd, Kaohsiung 83301, Taiwan.; Wang, LJ (corresponding author), Kaohsiung Chang Gung Mem Hosp, Dept Child & Adolescent Psychiat, 123 Ta Pei Rd, Kaohsiung, Taiwan.; Wang, LJ (corresponding author), Chang Gung Univ, Coll Med, Dept Chinese Med, Taoyuan, Taiwan.
EM wangliangjen@gmail.com
RI Wang, Liang-Jen/AAR-1089-2020; Lin, Pao-Yen/V-2495-2019
OI Wu, Chih-Ching/0000-0002-7264-9672; Huang, Yu-Chi/0000-0002-1143-9073;
   Wang, Liang-Jen/0000-0002-5320-1151
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NR 55
TC 13
Z9 14
U1 2
U2 19
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
EI 1873-3360
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD NOV
PY 2016
VL 73
BP 1
EP 8
DI 10.1016/j.psyneuen.2016.07.209
PG 8
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA DY7QQ
UT WOS:000385324800001
PM 27448522
DA 2025-06-11
ER

PT J
AU Martínez-Martínez, E
   Rodríguez, C
   Galán, M
   Miana, M
   Jurado-López, R
   Bartolomé, MV
   Luaces, M
   Islas, F
   Martínez-González, J
   López-Andrés, N
   Cachofeiro, V
AF Martinez-Martinez, Ernesto
   Rodriguez, Cristina
   Galan, Maria
   Miana, Maria
   Jurado-Lopez, Raquel
   Visitation Bartolome, Maria
   Luaces, Maria
   Islas, Fabian
   Martinez-Gonzalez, Jose
   Lopez-Andres, Natalia
   Cachofeiro, Victoria
TI The lysyl oxidase inhibitor (β-aminopropionitrile) reduces leptin
   profibrotic effects and ameliorates cardiovascular remodeling in
   diet-induced obesity in rats
SO JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
LA English
DT Article
DE Fibrosis; Leptin; Lysyl oxidase; Obesity
ID COLLAGEN CROSS-LINKING; HEART-FAILURE; METABOLIC SYNDROME; POTENTIAL
   ROLE; EXTRACELLULAR-MATRIX; MYOCARDIAL FIBROSIS; CARDIAC FIBROSIS;
   EXPRESSION; MICE; CELLS
AB Lysyl oxidase (LOX) is an extracellular matrix (ECM)-modifying enzyme that has been involved in cardiovascular remodeling. We explore the impact of LOX inhibition in ECM alterations induced by obesity in the cardiovascular system. LOX is overexpressed in the heart and aorta from rats fed a high-fat diet (HFD). beta-Aminopropionitrile (BAPN), an inhibitor of LOX activity, significantly attenuated the increase in body weight and cardiac hypertrophy observed in HFD rats. No significant differences were found in cardiac function or blood pressure among any group. However, HFD rats showed cardiac and vascular fibrosis and enhanced levels of superoxide anion (O-2(center dot-)), collagen I and transforming growth factor beta (TGF-beta) in heart and aorta and connective tissue growth factor (CTGF) in aorta, effects that were attenuated by LOX inhibition. Interestingly, BAPN also prevented the increase in circulating leptin levels detected in HFD fed animals. Leptin increased protein levels of collagen I, TGF-beta and CTGF, Akt phosphorylation and O-2(center dot-) production in both cardiac myofibroblasts and vascular smooth muscle cells in culture, while LOX inhibition ameliorated these alterations. LOX knockdown also attenuated leptin-induced collagen I production in cardiovascular cells. Our findings indicate that LOX inhibition attenuates the fibrosis and the oxidative stress induced by a HFD on the cardiovascular system. The reduction of leptin levels by BAPN in vivo and the ability of this compound to inhibit leptin-induced profibrotic mediators and ROS production in cardiac and vascular cells suggest that interactions between leptin and LOX regulate downstream events responsible for myocardial and vascular fibrosis in obesity. (C) 2016 Elsevier Ltd. All rights reserved.
C1 [Martinez-Martinez, Ernesto; Miana, Maria; Jurado-Lopez, Raquel; Cachofeiro, Victoria] Univ Complutense, Dept Physiol, Sch Med, IiSGM, E-28040 Madrid, Spain.
   [Rodriguez, Cristina; Galan, Maria; Martinez-Gonzalez, Jose] IIB St Pau, Ctr Invest Cardiovasc CSIC ICCC, Barcelona, Spain.
   [Visitation Bartolome, Maria] Univ Complutense, Dept Ophthalmol & Otorhinolaringol, Fac Psychol, E-28040 Madrid, Spain.
   [Luaces, Maria; Islas, Fabian] Hosp Clin San Carlos, Cardiovasc Inst, Dept Cardiol, Madrid, Spain.
   [Lopez-Andres, Natalia] Inst Invest Sanitaria Navarra IdiSNA, Cardiovasc Translat Res, Navarrabiomed Fdn Miguel Servet, Pamplona, Spain.
C3 Complutense University of Madrid; Consejo Superior de Investigaciones
   Cientificas (CSIC); CSIC - Institut Catala de Ciencies Cardiovasculars
   (ICCC); Complutense University of Madrid; Hospital Clinico San Carlos;
   Navarrabiomed
RP Cachofeiro, V (corresponding author), Univ Complutense, Dept Fisiol, Fac Med, E-28040 Madrid, Spain.
EM vcara@ucm.es
RI LUACES, MARIA/E-6502-2010; Islas, Fabián/HTO-5905-2023; Lopez-Andres,
   Natalia/B-1276-2017; Rodriguez, Cristina/D-3099-2011; Martinez-Martinez,
   Ernesto/M-1376-2017; Galan, Maria/S-3173-2018
OI Lopez-Andres, Natalia/0000-0003-3728-2606; Martinez-Gonzalez,
   Jose/0000-0002-3894-7166; Jurado Lopez, Raquel/0000-0002-9149-1073;
   Miana, Maria/0000-0002-0801-8024; Luaces, Maria/0000-0001-9529-9655;
   BARTOLOME PASCUAL, MARIA VISITACION/0000-0002-5740-8141; Rodriguez,
   Cristina/0000-0002-6472-5647; Martinez-Martinez,
   Ernesto/0000-0002-3011-2041; Cachofeiro, Victoria/0000-0001-6959-6293;
   Galan, Maria/0000-0002-4758-8388
FU Red de Investigation Cardiovascular [RD12/0042/0033, RD12/0042/0053];
   Miguel Servet Programme from ISCIII [CP13/00221]; Fondo Europeo de
   Desarrollo Regional (FEDER); Plan Estatal I + D + I [PI12/01729,
   PI12/01952]
FX This work was supported by grants from Plan Estatal I + D + I2013-2016:
   PI12/01729, PI12/01952, Red de Investigation Cardiovascular
   [RD12/0042/0033 and RD12/0042/0053] and Miguel Servet Programme
   [CP13/00221] from ISCIII. The study was cofunded by Fondo Europeo de
   Desarrollo Regional (FEDER), a way to build Europe.
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NR 47
TC 48
Z9 54
U1 0
U2 14
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0022-2828
EI 1095-8584
J9 J MOL CELL CARDIOL
JI J. Mol. Cell. Cardiol.
PD MAR
PY 2016
VL 92
BP 96
EP 104
DI 10.1016/j.yjmcc.2016.01.012
PG 9
WC Cardiac & Cardiovascular Systems; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Cell Biology
GA DH9DD
UT WOS:000373095700012
PM 26780438
DA 2025-06-11
ER

PT J
AU Santamarina, AB
   Oliveira, JL
   Silva, FP
   Carnier, J
   Mennitti, LV
   Santana, AA
   de Souza, GHI
   Ribeiro, EB
   do Nascimento, CMO
   Lira, FS
   Oyama, LM
AF Santamarina, Aline B.
   Oliveira, Juliana L.
   Silva, Fernanda P.
   Carnier, June
   Mennitti, Lais V.
   Santana, Aline A.
   de Souza, Gabriel H. I.
   Ribeiro, Eliane B.
   Oller do Nascimento, Claudia M.
   Lira, Fabio S.
   Oyama, Lila M.
TI Green Tea Extract Rich in Epigallocatechin-3-Gallate Prevents Fatty
   Liver by AMPK Activation via LKB1 in Mice Fed a High-Fat Diet
SO PLOS ONE
LA English
DT Article
ID PROTEIN-KINASE; INSULIN-RESISTANCE; METABOLIC SYNDROME; OXIDATIVE
   STRESS; NONALCOHOLIC STEATOHEPATITIS; HEPATIC STEATOSIS;
   ENERGY-METABOLISM; LIPID-METABOLISM; RECENT PROGRESS; RAT MODEL
AB Supplementation with epigallocatechin-3-gallate has been determined to aid in the prevention of obesity. Decaffeinated green tea extract appears to restore a normal hepatic metabolic profile and attenuate high-fat diet (HFD)-induced effects, thereby preventing nonalcoholic fatty liver disease in mice. Mice were maintained on either a control diet (CD) or HFD for 16 weeks and supplemented with either water or green tea extract (50 mg/kg/day). The body mass increase, serum adiponectin level, and lipid profile were measured over the course of the treatment. Furthermore, the AMPK pathway protein expression in the liver was measured. From the fourth week, the weight gain in the CD + green tea extract (CE) group was lower than that in the CD + water (CW) group. From the eighth week, the weight gain in the HFD + water (HFW) group was found to be higher than that in the CW group. Moreover, the weight gain in the HFD + green tea extract (HFE) group was found to be lower than that in the HFW group. Carcass lipid content was found to be higher in the HFW group than that in the CW and HFE groups. Serum analysis showed reduced non-esterified fatty acid level in the CE and HFE groups as compared with their corresponding placebo groups. Increased adiponectin level was observed in the same groups. Increased VLDL-TG secretion was observed in the HFW group as compared with the CW and HFE groups. Increased protein expression of AdipoR2, SIRT1, pLKB1, and pAMPK was observed in the HFE group, which explained the reduced expression of ACC, FAS, SREBP-1, and ChREBP in this group. These results indicate that the effects of decaffeinated green tea extract may be related to the activation of AMPK via LKB1 in the liver of HFD-fed mice.
C1 [Santamarina, Aline B.; Oliveira, Juliana L.; Silva, Fernanda P.; Carnier, June; Santana, Aline A.; Ribeiro, Eliane B.; Oller do Nascimento, Claudia M.; Oyama, Lila M.] Univ Fed Sao Paulo, Dept Fisiol, Sao Paulo, Brazil.
   [Mennitti, Lais V.] Univ Fed Sao Paulo, Programa Posgrad Interdisciplinar Ciencias Saude, Santos, Brazil.
   [de Souza, Gabriel H. I.] Univ Sao Judas Tadeu, Lab Movimento Humano, Sao Paulo, Brazil.
   [Lira, Fabio S.] Univ Estadual Paulista, UNESP, Dept Phys Educ, Exercise & Immunometab Res Grp, Presidente Prudente, SP, Brazil.
C3 Universidade Federal de Sao Paulo (UNIFESP); Universidade Federal de Sao
   Paulo (UNIFESP); Universidade Sao Judas Tadeu; Universidade Estadual
   Paulista
RP Oyama, LM (corresponding author), Univ Fed Sao Paulo, Dept Fisiol, Sao Paulo, Brazil.
EM lmoyama@gmail.com
RI Mennitti, Lais/E-8659-2019; Oyama, Lila/B-7609-2012; Ribeiro,
   Eliane/C-8124-2012; Santamarina, Aline/AAI-7639-2020; do Nascimento,
   Claudia/T-4151-2019; de Oliveira, Juliana/JXY-0793-2024; Lira,
   Fabio/Q-7581-2016
OI Mennitti, Lais Vales/0000-0002-9326-7649; Lira,
   Fabio/0000-0002-9645-1003; Lopez de Oliveira,
   Juliana/0000-0003-2841-5980; Silva, Fernanda/0000-0003-3758-5797
FU Fundacao de Amparo a Pesquisa do Estado de Sao Paulo [2014/19508-7];
   Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior; Fundacao de
   Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [14/19508-7] Funding
   Source: FAPESP
FX This work was funded by Fundacao de Amparo a Pesquisa do Estado de Sao
   Paulo 2014/19508-7 - grant to: Dr Lila Missae Oyama and Coordenacao de
   Aperfeicoamento de Pessoal de Nivel Superior - grant to Aline Boveto
   Santamarina.
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NR 90
TC 81
Z9 88
U1 0
U2 31
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD NOV 4
PY 2015
VL 10
IS 11
AR e0141227
DI 10.1371/journal.pone.0141227
PG 18
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA CV5GZ
UT WOS:000364298400055
PM 26536464
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Wu, ZY
   Wang, MH
   Qi, HM
   Wu, MH
   Ge, YZ
   Li, HT
AF Wu, Zhi-Yong
   Wang, Meng-Hong
   Qi, Hong-Mei
   Wu, Mei-Hua
   Ge, Yu-Zhi
   Li, Hua-Tai
TI Relationship between hOGG1 Ser326Cys gene polymorphism and coronary
   artery lesions in patients with diabetes mellitus
SO INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
LA English
DT Article
DE hOGG1; polymorphism; 8-hydroxy deoxyguanosine; diabetes mellitus;
   coronary artery lesions
ID OXIDATIVE DNA-DAMAGE; METABOLIC SYNDROME; RISK-FACTOR; STRESS; DISEASE;
   ATHEROSCLEROSIS; MARKER; REPAIR; CELLS; ASSOCIATION
AB To study the relationship between human 8-oxoguanine glycosylase (hOGG1) Ser326Cys gene polymorphism and coronary artery lesions in patients with diabetes mellitus, we analyzed 323 patients with diabetic mellitus, who underwent coronary angiography. Using PCR-RFLP, these patients were grouped into three genotypes: Cys/Cys (n= 85), Ser/Ser (n= 121), and Ser/Cys (n= 117). Several clinical data, including history of diseases and biochemical indices were recorded. hOGG1 mRNA expression and 8-hydroxy deoxyguanosine (8-OHdG) were measured by RT-PCR and ELISA, respectively. The quantities and severity of coronary artery with lesions were analyzed from coronary angiography. The Gensini and SYNTAX scores were detected by the unitary criteria. The 8-OHdG levels showed statistical difference among the three genotypes (F= 21.56, P< 0.05). Also, 8-OHdG in Cys/Cys genotype was higher than Ser/Ser and Ser/Cys genotype (q= 2.32, q= 3.12, P< 0.05). In terms of the expression of hOGGl mRNA, the measure of hOGGl/beta-actin showed significant difference among the three groups (F= 12.56, P< 0.05). On comparing two groups, hOGGl/beta-actin in Cys/Cys genotype was higher thanSer/Ser and Ser/Cys genotypes (q= 2.32, q= 3.12, P< 0.05). Percentage of 3-vessel lesions was high in Cys/Cys genotype and percentage of 1-vessel lesions was low in Ser/Cys genotype. Gensini and SYNTAX scores and ratio of complex lesions were significantly higher in the Cys/Cys genotype than the other two genotypes (F-Gensini= 47.16, F-SYNTAX= 55.12; P< 0.05). hOGG1 Ser326Cys polymorphism showed correlation with coronary artery lesions in patients with diabetes mellitus, and Cys/Cys genotype may have more impact on the severity of lesions.
C1 [Wu, Zhi-Yong] Nanchang Univ, Coll Med, Grad Dept, Nanchang 330031, Peoples R China.
   [Wu, Zhi-Yong] Jiangxi Prov Peoples Hosp, Dept Cardiol, Nanchang 338025, Peoples R China.
   [Wang, Meng-Hong; Qi, Hong-Mei] Nanchang Univ, Dept Cardiol, Affiliated Hosp 1, Nanchang, Peoples R China.
   [Wu, Mei-Hua; Ge, Yu-Zhi; Li, Hua-Tai] Cardiovasc Dis Inst Jiangxi Prov, Nanchang, Peoples R China.
C3 Nanchang University; Nanchang University
RP Wu, ZY (corresponding author), Nanchang Univ, Coll Med, Grad Dept, Nanchang 330031, Peoples R China.
EM wuzhiyong76@163.com
RI Wang, Menghong/LSL-4399-2024
CR Bruner SD, 2000, NATURE, V403, P859, DOI 10.1038/35002510
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NR 23
TC 4
Z9 4
U1 0
U2 0
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 1940-5901
J9 INT J CLIN EXP MED
JI Int. J. Clin. Exp. Med.
PY 2015
VL 8
IS 10
BP 18629
EP 18637
PG 9
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA DA3BB
UT WOS:000367669800184
PM 26770476
DA 2025-06-11
ER

PT J
AU Najam, SS
   Sun, JC
   Zhang, J
   Xu, M
   Lu, JL
   Sun, K
   Li, MA
   Wang, TG
   Bi, YF
   Ning, G
AF Najam, Syeda Sadia
   Sun, Jichao
   Zhang, Jie
   Xu, Min
   Lu, Jieli
   Sun, Kan
   Li, Mian
   Wang, Tiange
   Bi, Yufang
   Ning, Guang
TI Serum total bilirubin levels and prevalence of diabetic retinopathy in a
   Chinese population
SO JOURNAL OF DIABETES
LA English
DT Article
DE bilirubin; diabetes mellitus; diabetic complications; retinopathy
ID METABOLIC SYNDROME; OXIDATIVE STRESS; MELLITUS; DISEASE; COMPLICATIONS;
   ASSOCIATION; HEALTH; RISK; MEN
AB BackgroundPatients with type 2 diabetes (T2D) are at a high risk of developing microvascular complications, such as diabetic retinopathy (DR). Previous studies have shown that low serum bilirubin concentrations in T2D patients may increase the risk of diabetic complications. Thus, the aim of the present was to investigate the association between the prevalence of DR and serum concentrations of total bilirubin in a Chinese population.
   MethodsThe present study was a population-based cross-sectional study on 1761 T2D patients aged 40 years from the Jiading district of Shanghai, China. Fundus photographs were taken to confirm the presence and severity of DR. Subjects were assigned to quartiles based on serum total bilirubin concentrations (Quartile (Q) 1 <0.60mg/dL; Q2 0.60-0.76mg/dL; Q3 0.77-0.99mg/dL; Q4 >0.99mg/dL). Logistic regression models were used to explore the association between bilirubin concentrations and the prevalence of DR.
   ResultsThe prevalence of DR in the entire study population was 9.6%. The prevalence of DR was significantly lower in Q4 compared with the other three quartiles (P-trend=0.004). After adjustment for multiple confounding factors, T2D patients in Q4 (i.e. serum bilirubin >0.99mg/dL) were less likely (odds ratio 0.55; 95% confidence interval 0.33-0.91) to suffer from DR than patients in Q1 (i.e. serum bilirubin <0.60mg/dL).
   ConclusionSerum bilirubin concentrations were inversely associated with DR in an elderly Chinese population, independent of traditional risk factors for microvascular complications.
   ??
   ??2????????????????????????????????????,???????????????????????????????????????????????????????????????
   ???????????????,??????1761???????40????????????????????????????????????????????????????(Q1< 0.60 mg/dL;Q20.60-0.76 mg/dL;Q30.77-0.99 mg/dL;Q4> 0.99 mg/dL),????????????Logistic?????????????????????????
   ????????????????9.6%???????????????????????????????????3?(??P = 0.004)??????????,???????????????????,?????????????????????????????????(OR = 0.55,95%????CI0.33-0.91)?
   ????????,???????????????????????????,??????????????????????
C1 [Najam, Syeda Sadia; Sun, Jichao; Zhang, Jie; Xu, Min; Lu, Jieli; Sun, Kan; Li, Mian; Wang, Tiange; Bi, Yufang; Ning, Guang] Shanghai Jiao Tong Univ, Key Lab Endocrine & Metab Dis, E Inst Shanghai Univ, Minist Hlth,Rui Jin Hosp,Sch Med, Shanghai 200025, Peoples R China.
   [Najam, Syeda Sadia; Sun, Jichao; Zhang, Jie; Xu, Min; Lu, Jieli; Sun, Kan; Li, Mian; Wang, Tiange; Bi, Yufang; Ning, Guang] Shanghai Jiao Tong Univ, Shanghai Clin Ctr Endocrine & Metab Dis, Shanghai Inst Endocrine & Metab Dis, Dept Endocrine & Metab Dis,Rui Jin Hosp,Sch Med, Shanghai 200025, Peoples R China.
   [Najam, Syeda Sadia] Natl Inst Biotechnol & Genet Engn, Faisalabad, Pakistan.
C3 Shanghai Jiao Tong University; Shanghai Jiao Tong University; Pakistan
   Institute of Engineering & Applied Science
RP Ning, G (corresponding author), Shanghai Jiao Tong Univ, Shanghai Clin Ctr Endocrine & Metab Dis, Shanghai Inst Endocrine & Metab Dis, Dept Endocrine & Metab Dis,Rui Jin Hosp,Sch Med, 197 Rui Jin 2nd Rd, Shanghai 200025, Peoples R China.
EM gning@sibs.ac.cn
RI Wang, Tiange/MCX-9826-2025; bi, yu/JOK-3859-2023; Martinez,
   Ramfis/I-7205-2019; Najam, Sadia/AAH-3072-2020; lu, jieli/JJG-0395-2023;
   Li, Mian/HGE-6038-2022
OI Wang, Tiange/0000-0003-0723-489X
FU World Academy of Sciences; Chinese Academy of Sciences; Key Laboratory
   for Endocrine and Metabolic Diseases of the Ministry of Health
   [1994DP131044]; Sector Funds of the Ministry of Health [201002002];
   National Key New Drug Creation and Manufacturing Program of the Ministry
   of Science and Technology [2012ZX09303006-001]; National Natural Science
   Foundation of China [81222008, 81170719]
FX The authors are grateful to all the participants, without whom the study
   would not have been possible. The authors also thank The World Academy
   of Sciences and the Chinese Academy of Sciences for awarding SSN a
   postgraduate fellowship. The present study was supported by grants from
   the Key Laboratory for Endocrine and Metabolic Diseases of the Ministry
   of Health (1994DP131044), Sector Funds of the Ministry of Health
   (201002002), the National Key New Drug Creation and Manufacturing
   Program of the Ministry of Science and Technology (2012ZX09303006-001),
   and the National Natural Science Foundation of China (81222008,
   81170719).
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NR 36
TC 21
Z9 23
U1 0
U2 11
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1753-0393
EI 1753-0407
J9 J DIABETES
JI J. Diabetes
PD MAY
PY 2014
VL 6
IS 3
BP 221
EP 227
DI 10.1111/1753-0407.12085
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA AF0YQ
UT WOS:000334441600005
PM 24034422
DA 2025-06-11
ER

PT J
AU Athinarayanan, S
   Wei, RR
   Zhang, M
   Bai, SC
   Traber, MG
   Yates, K
   Cummings, OW
   Molleston, J
   Liu, WQ
   Chalasani, N
AF Athinarayanan, Shaminie
   Wei, Rongrong
   Zhang, Min
   Bai, Shaochun
   Traber, Maret G.
   Yates, Katherine
   Cummings, Oscar W.
   Molleston, Jean
   Liu, Wanqing
   Chalasani, Naga
TI Genetic Polymorphism of Cytochrome P450 4F2, Vitamin E Level and
   Histological Response in Adults and Children with Nonalcoholic Fatty
   Liver Disease Who Participated in PIVENS and TONIC Clinical Trials
SO PLOS ONE
LA English
DT Article
ID OMEGA-HYDROXYLASE PATHWAY; TYPE-1 DIABETES-MELLITUS; METABOLIC SYNDROME;
   OXIDATIVE STRESS; ALPHA-TOCOPHEROL; COMMON VARIANTS; BLOOD-PRESSURE;
   V433M VARIANT; CYP4F2; 20-HETE
AB Vitamin E improved liver histology in children and adults with NAFLD who participated in TONIC and PIVENS clinical trials, but with significant inter-individual variability in its efficacy. Cytochrome P450 4F2 (CYP4F2) is the major enzyme metabolizing Vit E, with two common genetic variants (V433M, rs2108622 and W12G, rs3093105) found to alter its activity. We investigated the relationship between CYP4F2 genotypes, alpha-tocopherol levels and histological improvement in these two trials. V433M and W12G variants were genotyped in TONIC (n = 155) and PIVENS (n = 213) DNA samples. The relationships between CYP4F2 genotypes, plasma alpha-tocopherol levels at baseline and weeks 48 (w48) and 96 (w96) and histological end points (overall improvement in liver histology and resolution of NASH) were investigated. As a result, the V433M genotype was significantly associated with baseline plasma alpha-tocopherol in the TONIC trial (p = 0.004), but not in PIVENS. Among those receiving Vit E treatment, CYP4F2 V433M genotype was associated with significantly decreased plasma alpha-tocopherol levels at w48 (p = 0.003 for PIVENS and p = 0.026 for TONIC) but not at w96. The w96 alpha-tocopherol level was significantly associated with resolution of NASH (p = 0.006) and overall histology improvement (p = 0.021) in the PIVENS, but not in the TONIC trial. There was no significant association between CYP4F2 genotypes and histological end points in either trial. Our study suggested the a moderate role of CYP4F2 polymorphisms in affecting the pharmacokinetics of Vit E as a therapeutic agent. In addition, there may be age-dependent relationship between CYP4F2 genetic variability and Vit E pharmacokinetics in NAFLD.
C1 [Athinarayanan, Shaminie; Wei, Rongrong; Liu, Wanqing] Purdue Univ, Dept Med Chem & Mol Med, W Lafayette, IN 47907 USA.
   [Zhang, Min] Purdue Univ, Dept Stat, W Lafayette, IN 47907 USA.
   [Bai, Shaochun] Indiana Univ Sch Med, Dept Med & Mol Genet, Indianapolis, IN 46202 USA.
   [Traber, Maret G.] Oregon State Univ, Linus Pauling Inst, Corvallis, OR 97331 USA.
   [Yates, Katherine] Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MA USA.
   [Cummings, Oscar W.] Indiana Univ Sch Med, Dept Pathol & Lab Med, Indianapolis, IN 46202 USA.
   [Molleston, Jean] Indiana Univ Sch Med, Dept Pediat, Indianapolis, IN 46202 USA.
   [Liu, Wanqing; Chalasani, Naga] Indiana Univ Sch Med, Div Gastroenterol & Hepatol, Indianapolis, IN 46202 USA.
   [Liu, Wanqing; Chalasani, Naga] Indiana Univ Sch Med, Indiana Fatty Liver Dis Res Grp, Indianapolis, IN 46202 USA.
C3 Purdue University System; Purdue University; Purdue University System;
   Purdue University; Indiana University System; Indiana University
   Bloomington; Oregon State University; Johns Hopkins University; Indiana
   University System; Indiana University Bloomington; Indiana University
   System; Indiana University Bloomington; Indiana University System;
   Indiana University Bloomington; Indiana University System; Indiana
   University Bloomington
RP Liu, WQ (corresponding author), Purdue Univ, Dept Med Chem & Mol Med, W Lafayette, IN 47907 USA.
EM liu781@purdue.edu; nchalasa@iu.edu
RI Athinarayanan, Shaminie/ABH-3703-2020; Traber, Maret/ABI-2511-2020
OI Traber, Maret/0000-0002-2892-4024
FU NIH/NIDDK [R21 DK090437]; Department of Medicinal Chemistry and
   Molecular Pharmacology, Purdue University; NIH [U01DK061737,
   U01DK061730]
FX This study was supported in part by the NIH/NIDDK grant (R21 DK090437)
   (WL) and the start-up fund (WL) by the Department of Medicinal Chemistry
   and Molecular Pharmacology, Purdue University. The NASH CRN Clinical
   Center at Indiana University is supported by the NIH grant U01DK061737,
   and the data coordinating center at Johns Hopkins School of Public
   Health is supported by the NIH grant U01DK061730. The authors would like
   to thank Dr. Rohit Loomba for his participation in the discussion and
   suggestions on data interpretation. The authors thank authors,
   coordinators, and participants of the PIVENS and TONIC clinical trials
   and a full list of authors is available from references 4 and 5. The
   funders had no role in study design, data collection and analysis,
   decision to publish, or preparation of the manuscript.
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NR 46
TC 29
Z9 32
U1 0
U2 10
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD APR 23
PY 2014
VL 9
IS 4
AR e95366
DI 10.1371/journal.pone.0095366
PG 9
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA AG3EI
UT WOS:000335298200050
PM 24759732
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Özçaka, O
   Buduneli, N
   Ceyhan, BO
   Akcali, A
   Hannah, V
   Nile, C
   Lappin, DF
AF Ozcaka, Ozgun
   Buduneli, Nurcan
   Ceyhan, Banu Ozturk
   Akcali, Aliye
   Hannah, Victoria
   Nile, Christopher
   Lappin, David F.
TI Is Interleukin-17 Involved in the Interaction Between Polycystic Ovary
   Syndrome and Gingival Inflammation?
SO JOURNAL OF PERIODONTOLOGY
LA English
DT Article
DE Gingivitis; interleukin-17; polycystic ovary syndrome
ID IMPAIRED GLUCOSE-TOLERANCE; GRADE CHRONIC INFLAMMATION; OXIDATIVE
   STRESS; PERIODONTAL-DISEASE; METABOLIC SYNDROME; DIABETES-MELLITUS;
   SYNDROME PCOS; IL-17; WOMEN; RISK
AB Background: Polycystic ovarian syndrome (PCOS) is a hormonal disorder of females of reproductive age that impacts their oral and systemic health. The aim of this study is to evaluate interleukin-17A (IL-17A), IL-17F, IL-17A/F, and IL-17E (IL-25) levels in gingival crevicular fluid (GCF), saliva, and serum of non-obese females with PCOS and with either a clinically healthy periodontium or gingivitis.
   Methods: Thirty-one females with PCOS, 30 females with PCOS and gingivitis, and 12 systemically and periodontally healthy females participated in the study. Clinical periodontal measurements, body mass index, and Ferriman Gallwey score (FGS) (a measure of hirsutism in females) were recorded. Circulating levels of sex hormones, cortisol, and insulin were also determined. Levels of IL-17 cytokines were measured by enzyme-linked immunosorbent assay.
   Results: The general linear model multivariate analysis, adjusting for age or plaque index, showed that the two groups with PCOS had higher concentrations of IL-17A, IL17F, and IL-17A/F in serum and higher levels of IL-17A and IL-17F in GCF and saliva but lower serum IL-17E than systemically healthy females. Levels of IL-17E were lowest in females with PCOS and gingivitis who also had the highest FGS. Serum IL-17A and IL-17F levels correlated positively with FGS and periodontal probing depth (all r > 0.33; P < 0.005). Serum IL-17E showed the reverse relationship and also correlated negatively with IL-17A (r >-0.28; P < 0.05).
   Conclusions: IL-17 levels are altered in non-obese females with PCOS and may influence gingival inflammation. Additional studies are warranted to clarify the relationship between PCOS and gingivitis.
C1 [Ozcaka, Ozgun; Buduneli, Nurcan; Akcali, Aliye] Ege Univ, Sch Dent, Dept Periodontol, Izmir, Turkey.
   [Ceyhan, Banu Ozturk] Ege Univ, Sch Med, Dept Internal Med, Endocrinol & Metab Unit, Izmir, Turkey.
   [Hannah, Victoria; Nile, Christopher; Lappin, David F.] Univ Glasgow, Coll Med Vet & Life Sci, Glasgow Dent Hosp & Sch, Infect & Immun Res Grp, Glasgow G2 3JZ, Lanark, Scotland.
C3 Ege University; Ege University; University of Glasgow
RP Lappin, DF (corresponding author), Univ Glasgow, Coll Med Vet & Life Sci, Glasgow Dent Hosp & Sch, Glasgow G2 3JZ, Lanark, Scotland.
EM david.lappin@glasgow.ac.uk
RI AKCALI, Aliye/ABF-4819-2020; Buduneli, Nurcan/F-6869-2013; Nile,
   Christopher/AAJ-5982-2020; OZCAKA, ozgun/HHN-7128-2022
OI Nile, Christopher/0000-0001-8218-2167; Buduneli,
   Nurcan/0000-0002-1590-5801
FU Ege University Research Foundation; Tenovus Scotland at the Royal
   College of Physicians and Surgeons of Glasgow; University of Glasgow
FX This study was supported by grants from the Ege University Research
   Foundation (2009 DIS 024) and Tenovus Scotland at the Royal College of
   Physicians and Surgeons of Glasgow and by funds from the University of
   Glasgow. The authors report no conflicts of interest related to this
   study.
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NR 50
TC 49
Z9 53
U1 0
U2 38
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-3492
EI 1943-3670
J9 J PERIODONTOL
JI J. Periodont.
PD DEC
PY 2013
VL 84
IS 12
BP 1827
EP 1837
DI 10.1902/jop.2013.120483
PG 11
WC Dentistry, Oral Surgery & Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dentistry, Oral Surgery & Medicine
GA 275OI
UT WOS:000328686300017
PM 23327719
DA 2025-06-11
ER

PT J
AU Vekic, J
   Jelic-Ivanovic, Z
   Spasojevic-Kalimanovska, V
   Memon, L
   Zeljkovic, A
   Bogavac-Stanojevic, N
   Spasic, S
AF Vekic, Jelena
   Jelic-Ivanovic, Zorana
   Spasojevic-Kalimanovska, Vesna
   Memon, Lidija
   Zeljkovic, Aleksandra
   Bogavac-Stanojevic, Natasa
   Spasic, Slavica
TI High serum uric acid and low-grade inflammation are associated with
   smaller LDL and HDL particles
SO ATHEROSCLEROSIS
LA English
DT Article
DE Uric acid; Inflammation; hsCRP; Small, dense LDL; HDL size
ID C-REACTIVE PROTEIN; METABOLIC-SYNDROME; OXIDATIVE STRESS; DISEASE;
   MARKERS; ATHEROSCLEROSIS; HYPERTENSION
AB Elevated serum uric acid (UA) is associated with higher risk for cardiovascular disease (CVD). Smaller, denser low density lipoprotein (LDL) and high-density lipoprotein (HDL) particles are the potential risk factors for CVD, while the role and diagnostic value of inflammatory markers are firmly established. This current cross-sectional study investigates interrelationships between UA, high sensitivity C-reactive protein (hsCRP) and fibrinogen concentrations with LDL and HDL sizes in healthy middle-aged subjects. The outcomes-of-interest were smaller, denser LDL and HDL particles (LDL size <= 25.5 nm and HDL size <= 8.8 nm). Serum UA, hsCRP and plasma fibrinogen concentrations were measured by standard laboratory methods in a sample of 194 healthy volunteers (112 men and 82 women). LDL and HDL particle sizes were determined by gradient gel electrophoresis. The subjects in the highest UA tertile had significantly smaller LDL and HDL particle sizes (P < 0.05 and P < 0.01, respectively) and higher concentrations of fibrinogen and hsCRP (P < 0.05 and P < 0.01, respectively). Elevated UA (>= 318 mu mol/L) was a significant predictor of smaller, denser LDL and HDL particles (OR = 3.09; P < 0.01; n = 19 and OR = 4.40: P < 0.001; n = 23, respectively). The observed relationship with smaller HDL size persisted after adjustment for conventional cardiovascular risk factors. UA strongly correlated with both markers of inflammation. In addition, the higher hsCRP level correlated with smaller LDL size (P < 0.05), while fibrinogen concentration was inversely related to HDL size (P<0.05). Multiple regression analysis revealed that HDL size and inflammatory markers remained independent determinants of UA concentration. In conclusion, higher serum UA and low-grade inflammation are closely linked to alterations in lipoprotein metabolism which may represent an early sign of atherosclerosis in asymptomatic subjects. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
C1 [Vekic, Jelena; Jelic-Ivanovic, Zorana; Spasojevic-Kalimanovska, Vesna; Zeljkovic, Aleksandra; Bogavac-Stanojevic, Natasa; Spasic, Slavica] Fac Pharm, Inst Med Biochem, Belgrade 11000, Serbia.
   [Memon, Lidija] Clin Ctr Bezanijska Kosa, Clin Chem Lab, Belgrade, Serbia.
C3 University of Belgrade
RP Vekic, J (corresponding author), Fac Pharm, Inst Med Biochem, Vojvode Stepe 450,POB 146, Belgrade 11000, Serbia.
EM jelena.vekic@pharmacy.bg.ac.yu
OI Zeljkovic, Aleksandra/0000-0001-6417-8404; Vekic,
   Jelena/0000-0001-7445-0504
FU Ministry of Science and Environmental Protection, Republic of Serbia
   [145036B]
FX This work was supported by a grant from the Ministry of Science and
   Environmental Protection, Republic of Serbia (Project No. 145036B). The
   authors are grateful to Prof. Aleksandra Topic (Institute of Medical
   Biochemistry, Faculty of Pharmacy, Belgrade) for help in the
   implementation of gradient gel electrophoresis method in our laboratory.
   The authors would also like to thank Dr. David R. Jones for help in
   editing the manuscript.
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NR 35
TC 53
Z9 57
U1 0
U2 6
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0021-9150
EI 1879-1484
J9 ATHEROSCLEROSIS
JI Atherosclerosis
PD MAR
PY 2009
VL 203
IS 1
BP 236
EP 242
DI 10.1016/j.atherosclerosis.2008.05.047
PG 7
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 423QL
UT WOS:000264510700036
PM 18603253
DA 2025-06-11
ER

PT J
AU Aubin, MC
   Lajoie, C
   Clément, R
   Gosselin, H
   Calderone, A
   Perrault, LP
AF Aubin, Marie-Claude
   Lajoie, Claude
   Clement, Robert
   Gosselin, Hugues
   Calderone, Angelino
   Perrault, Louis P.
TI Female rats fed a high-fat diet were associated with vascular
   dysfunction and cardiac fibrosis in the absence of overt obesity and
   hyperlipidemia:: Therapeutic potential of resveratrol
SO JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
LA English
DT Article
ID NITRIC-OXIDE SYNTHASE; OXIDATIVE STRESS; FIBROBLAST PROLIFERATION;
   CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; PRESSURE-OVERLOAD;
   MESSENGER-RNAS; HEART; MICE; HYPERTROPHY
AB It remains presently unknown whether vascular reactivity is impaired and whether maladaptive cardiac remodeling occurs before the onset of overt obesity and in the absence of hyperlipidemia. Normal female rats were fed a high-fat diet for 8 weeks and were associated with a modest nonsignificant increase of body weight (standard diet, 300 +/- 10, versus high-fat diet, 329 +/- 14 g) and a normal plasma lipid profile. In rats fed a high-fat diet, systolic (171 +/- 7 mm Hg) and diastolic blood pressures (109 +/- 3) were increased compared to a standard diet (systolic blood pressure, 134 +/- 8; diastolic blood pressure, 96 +/- 5 mm Hg), and acetylcholine-dependent relaxation of isolated aortic rings (high-fat diet, 22 +/- 5%, versus standard diet, 53 +/- 8%) was significantly reduced. Furthermore, perivascular fibrosis was detected in the heart of rats fed a high-fat diet. The exogenous addition of resveratrol (trans-3,5,4'-trihydroxystilbene) (0.1 mu M) to aortic rings isolated from rats fed a high-fat diet restored acetylcholine-mediated relaxation (47 +/- 9%). The administration of resveratrol (20 mg/kg/day for 8 weeks) to rats fed a high-fat diet prevented the increase in blood pressure and preserved acetylcholine-dependent relaxation of isolated aortic rings. However, resveratrol therapy failed to attenuate the perivascular fibrotic response. These data have demonstrated that a high-fat diet fed to normal female rats can elicit a hypertensive response and induce perivascular fibrosis before the development of overt obesity and in the absence of hyperlipidemia. Resveratrol therapy can prevent the hypertensive response in female rats fed a high-fat diet but is without effect on the progression of perivascular fibrosis.
C1 [Aubin, Marie-Claude; Clement, Robert; Gosselin, Hugues; Calderone, Angelino; Perrault, Louis P.] Montreal Heart Inst, Res Ctr, Montreal, PQ H1T 1C8, Canada.
   [Aubin, Marie-Claude; Calderone, Angelino; Perrault, Louis P.] Univ Montreal, Dept Pharmacol, Montreal, PQ H3C 3J7, Canada.
   [Lajoie, Claude] Univ Quebec Trois Rivieres, Dept Sci Phys Act, Trois Rivieres, PQ GA9 5H7, Canada.
   [Calderone, Angelino] Univ Montreal, Dept Physiol, Montreal, PQ H3C 3J7, Canada.
   [Perrault, Louis P.] Univ Montreal, Dept Surg, Montreal, PQ H3C 3J7, Canada.
C3 Universite de Montreal; Universite de Montreal; University of Quebec;
   University of Quebec Trois Rivieres; Universite de Montreal; Universite
   de Montreal
RP Perrault, LP (corresponding author), Montreal Heart Inst, Res Ctr, 5000 Belanger St, Montreal, PQ H1T 1C8, Canada.
EM louis.perrault@icm-mhi.org
CR Baur JA, 2006, NATURE, V444, P337, DOI 10.1038/nature05354
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NR 33
TC 95
Z9 116
U1 0
U2 5
PU AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3995 USA
SN 0022-3565
EI 1521-0103
J9 J PHARMACOL EXP THER
JI J. Pharmacol. Exp. Ther.
PD JUN
PY 2008
VL 325
IS 3
BP 961
EP 968
DI 10.1124/jpet.107.135061
PG 8
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 301AL
UT WOS:000255868700031
PM 18356487
DA 2025-06-11
ER

PT J
AU Walker, BR
AF Walker, Brian R.
TI Extra-adrenal regeneration of glucocorticoids by 11β-hydroxysteroid
   dehydrogenase type 1:: physiological regulator and pharmacological
   target for energy partitioning
SO PROCEEDINGS OF THE NUTRITION SOCIETY
LA English
DT Article; Proceedings Paper
CT Summer Meeting of the Nutrition-Society
CY JUL 03-06, 2006
CL Aberdeen, SCOTLAND
SP Nutr Soc, Aberdeen Univ, Rowett Res Inst
DE glucocorticoids; 11 beta-hydroxysteroid dehydrogenase; energy
   partitioning; obesity; diabetes mellitus
ID SPLANCHNIC CORTISOL PRODUCTION; HEPATIC INSULIN SENSITIVITY;
   CARDIOVASCULAR RISK-FACTORS; MESSENGER-RIBONUCLEIC-ACID; VISCERAL
   ADIPOSE-TISSUE; STRESS-INDUCED CORTISOL; PITUITARY-ADRENAL AXIS;
   BODY-FAT DISTRIBUTION; IN-VIVO; METABOLIC SYNDROME
AB The major glucocorticoid in man, cortisol, plays important roles in regulating fuel metabolism, energy partitioning and body fat distribution. In addition to the control of cortisol levels in blood by the hypothalamic-pituitary-adrenal axis, intracellular cortisol levels within target tissues can be controlled by local enzymes. 11 beta-Hydroxysteroid dehydrogenase type I (11 beta-HSD1) catalyses the regeneration of active cortisol from inert cortisone, thereby amplifying cortisol levels and glucocorticoid receptor activation in adipose tissue, liver and other tissues. 11 beta-HSD1 is under complex tissue-specific regulation and there is evidence that it adjusts local cortisol concentrations independently of the plasma cortisol concentrations, e.g. in response to changes in diet. In obesity 11 beta-HSD1 mRNA and activity in adipose tissue are increased. The mechanism of this up-regulation remains uncertain; polymorphisms in the HSD11B1 gene have been associated with metabolic complications of obesity, including hypertension and type 2 diabetes, but not with obesity per se. Extensive data have been obtained in mice with transgenic over-expression of 11 beta-HSD1 in liver and adipocytes, targeted deletion of 11 beta-HSD1, and using novel selective 11 beta-HSD1 inhibitors; these data support the use of 11 beta-HSD1 inhibitors to lower intracellular glucocorticoid levels and treat both obesity and its metabolic complications. Moreover, in human subjects the non-selective 'prototype' inhibitor carbenoxolone enhances insulin sensitivity. Results of clinical studies with novel potent selective 11 beta-HSD1 inhibitors are therefore eagerly awaited. The present article focuses on the physiological role of glucocorticoids in regulating energy partitioning, and the evidence that this process is modulated by 11 beta-HSD1 in human subjects.
C1 Univ Edinburgh, Queens Med Res Inst, Ctr Cardiovasc Sci, Endocrinol Unit, Edinburgh EH16 4TJ, Midlothian, Scotland.
C3 University of Edinburgh
RP Walker, BR (corresponding author), Univ Edinburgh, Queens Med Res Inst, Ctr Cardiovasc Sci, Endocrinol Unit, 47 Little France Crescent, Edinburgh EH16 4TJ, Midlothian, Scotland.
EM B.Walker@ed.ac.uk
FU Wellcome Trust Funding Source: Medline
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NR 91
TC 36
Z9 39
U1 0
U2 3
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0029-6651
EI 1475-2719
J9 P NUTR SOC
JI Proc. Nutr. Soc.
PD FEB
PY 2007
VL 66
IS 1
BP 1
EP 8
DI 10.1017/S002966510700523X
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Nutrition & Dietetics
GA 154ZN
UT WOS:000245547400001
PM 17343766
OA Bronze, Green Submitted
DA 2025-06-11
ER

PT J
AU Ahanchi, NS
   Fischer, AS
   Quezada-Pinedo, HG
   Khatami, F
   Eisenga, MF
   Muka, T
   Vidal, PM
AF Ahanchi, Noushin Sadat
   Fischer, Amira Salome
   Quezada-Pinedo, Hugo G.
   Khatami, Farnaz
   Eisenga, Michele F.
   Muka, Taulant
   Vidal, Pedro-Marques
TI Cross-sectional and longitudinal associations of Iron biomarkers and
   cardiovascular risk factors in pre- and postmenopausal women: leveraging
   repeated measurements to address natural variability
SO CARDIOVASCULAR DIABETOLOGY
LA English
DT Article
DE Iron biomarkers; Menopause; Cohort; Cardio-metabolic risk factors
ID C-REACTIVE PROTEIN; SERUM FERRITIN; INSULIN-RESISTANCE; METABOLIC
   SYNDROME; GLUCOSE-INTOLERANCE; DIABETES-MELLITUS; OXIDATIVE STRESS;
   BLOOD-PRESSURE; MENOPAUSE; DISEASE
AB Background The association between iron biomarkers and cardiovascular disease risk factors (CVD-RFs) remains unclear. We aimed to (1) evaluate the cross-sectional and longitudinal associations between iron biomarkers (serum ferritin, transferrin saturation (TSAT), transferrin) and CVD-RFs among women, and (2) explore if these associations were modified by menopausal status. Method Cross-sectional and longitudinal analyses including 2542 and 1482 women from CoLaus cohort, respectively. Multiple linear regression and multilevel mixed models were used to analyse the associations between Iron biomarkers and CVD-RFs. Variability of outcomes and iron markers between surveys was accessed using intraclass correlation (ICC). Results After multivariable adjustment, elevated serum ferritin levels were associated with increased insulin and glucose levels, while higher transferrin levels were linked to elevated glucose, insulin and total cholesterol, and systolic and diastolic blood pressure (p < 0.05). No association was observed between CVD-RFs and TSAT (p > 0.05). Iron biomarkers demonstrated low reliability across reproductive stages but exhibited stronger associations in the perimenopausal group. In longitudinal analysis, we found association only for transferrin with lower glucose levels [beta = - 0.59, 95% CI (- 1.10, - 0.08), p = 0.02] and lower diastolic blood pressure [beta = - 7.81, 95% CI (- 15.9, - 0.56), p = 0.04]. Conclusion In cross-sectional analysis, transferrin was associated with several CVD-RFs, and the associations did not change according to menopausal status. Conversely, in the longitudinal analyses, changes in transferrin were associated only with lower glucose and diastolic blood pressure levels. These differences might stem from the substantial longitudinal variation of iron biomarkers, underscoring the need for multiple iron measurements in longitudinal analyses.
C1 [Ahanchi, Noushin Sadat; Fischer, Amira Salome; Khatami, Farnaz; Muka, Taulant] Univ Bern, Inst Social & Prevent Med, Bern, Switzerland.
   [Ahanchi, Noushin Sadat; Khatami, Farnaz] Univ Bern, Grad Sch Hlth Sci, Bern, Switzerland.
   [Quezada-Pinedo, Hugo G.] Univ Bern, Bern Univ Hosp, Dept Cardiol, Bern, Switzerland.
   [Quezada-Pinedo, Hugo G.] Generat R Study Grp, Rotterdam, Netherlands.
   [Eisenga, Michele F.] Univ Groningen, Dept Internal Med, Div Nephrol, Groningen, Netherlands.
   [Khatami, Farnaz] Univ Tehran Med Sci, Community Med Dept, Tehran, Iran.
   [Ahanchi, Noushin Sadat; Vidal, Pedro-Marques] Lausanne Univ Hosp, Dept Internal Med, Internal Med, Lausanne, Switzerland.
   [Muka, Taulant] Epistudia, Bern, Switzerland.
C3 University of Bern; University of Bern; University of Bern; University
   Hospital of Bern; University of Groningen; Tehran University of Medical
   Sciences; University of Lausanne; Centre Hospitalier Universitaire
   Vaudois (CHUV)
RP Ahanchi, NS (corresponding author), Univ Bern, Inst Social & Prevent Med, Bern, Switzerland.; Ahanchi, NS (corresponding author), Univ Bern, Grad Sch Hlth Sci, Bern, Switzerland.; Ahanchi, NS; Vidal, PM (corresponding author), Lausanne Univ Hosp, Dept Internal Med, Internal Med, Lausanne, Switzerland.
EM Noushinsadat.Ahanchi@chuv.ch; pedro-manuel.marques-vidal@chuv.ch
RI Quezada Pinedo, Hugo/JCN-8939-2023; Marques-Vidal, Pedro/C-9449-2009
OI Quezada Pinedo, Hugo Guillermo/0000-0002-0641-7718; khatami,
   Farnaz/0009-0000-6247-1455
FU University of Lausanne; GlaxoSmithKline; Faculty of Biology and Medicine
   of Lausanne; Swiss National Science Foundation [33CSCO-122661,
   33CS30-139468, 33CS30-148401, 33CS30-177535, 3247730-204523]; Swiss
   Personalized Health Network [2018DRI01]; Swiss Government Excellence
   Scholarship [2021.0899, 2022.0415]
FX Open access funding provided by University of Lausanne. The CoLaus study
   was supported by research grants from GlaxoSmithKline, the Faculty of
   Biology and Medicine of Lausanne, the Swiss National Science Foundation
   (grants 33CSCO-122661, 33CS30-139468, 33CS30-148401, 33CS30-177535 and
   3247730-204523) and the Swiss Personalized Health Network (Grant
   2018DRI01). N.S.A received funding from Swiss Government Excellence
   Scholarship (Grant agreement No 2021.0899). H.G.Q.P received funding
   from Swiss Government Excellence Scholarship (Grant agreement No
   2022.0415). The funders had no role in the design of the study; in the
   collection, analyses, or interpretation of data; in the writing of the
   manuscript; or in the decision to publish the results. All authors
   declare no specific funding for this contribution.
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NR 60
TC 2
Z9 2
U1 1
U2 1
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1475-2840
J9 CARDIOVASC DIABETOL
JI Cardiovasc. Diabetol.
PD MAY 7
PY 2024
VL 23
IS 1
AR 158
DI 10.1186/s12933-024-02242-x
PG 13
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism
GA PQ8W5
UT WOS:001215650400007
PM 38715055
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Alkhathami, K
   Soman, A
   Chandy, S
   Ramamoorthy, B
   Alqahtani, B
AF Alkhathami, Khalid
   Soman, Ajith
   Chandy, Sunil
   Ramamoorthy, Baranitharan
   Alqahtani, Bijad
TI Comparing the effects of retro and forward walking on serum adiponectin
   levels in obese young adults
SO JOURNAL OF TAIBAH UNIVERSITY MEDICAL SCIENCES
LA English
DT Article
DE Adiponectin; Inflammatory markers; Obesity indices; Retro walking;
   Treadmill training
ID MOLECULAR-WEIGHT ADIPONECTIN; BACKWARD WALKING; METABOLIC SYNDROME;
   HEART-RATE; HIP RATIO; EXERCISE; ADOLESCENTS; OVERWEIGHT; EXPRESSION;
   CAPACITY
AB Objectives: Retro walking or backward walking expends greater energy and places less stress on joints compared with forward walking at a similar speed. This study conducted in obese young men was primarily aimed at comparing the effects of backward walking with forward walking on adiponectin levels. The secondary aim was to describe the effects of concomitant factors, namely C -reactive protein, body mass index (BMI), waist to height ratio, and waist to hip ratio, on adiponectin levels in obese young men.Methods: In this randomized comparative study, 102 participants underwent either retro walking or forward walking treadmill training four times a week for 12 weeks before and after which adiponectin, C-reactive protein, BMI, waist to height ratio, and waist to hip ratio were measured. Comparison of the measured values before and after intervention and between the groups was done, and the influence of C-reactive protein, BMI, waist to height ratio, and waist to hip ratio on adiponectin levels was determined.Results: Adiponectin levels were significantly increased (p < 0.001) and C-reactive protein, BMI, waist to height ratio, and waist to hip ratio were significantly decreased (p < 0.001) post-intervention. The participants who un-derwent retro walking training showed a significantly higher change in C-reactive protein levels, BMI, and waist to hip ratio compared to the forward walking group (p < 0.001). Adiponectin levels were influenced by BMI (p < 0.001).Conclusion: Retro walking training leads to a greater increase in adiponectin and reduction in C-reactive pro-tein, BMI, waist to height ratio, and waist to hip ratio compared to forward walking, and adiponectin levels are influenced by BMI. Retro walking treadmill training can be preferentially used to decrease cardiovascular risk factors.
C1 [Alkhathami, Khalid; Soman, Ajith; Ramamoorthy, Baranitharan; Alqahtani, Bijad] Shaqra Univ, Coll Appl Med Sci, Dept Hlth Rehabil, Shaqra 11961, Saudi Arabia.
   [Chandy, Sunil] Shaqra Univ, Coll Appl Med Sci, Dept Clin Lab Sci, Shaqra, Saudi Arabia.
C3 Shaqra University; Shaqra University
RP Soman, A (corresponding author), Shaqra Univ, Coll Appl Med Sci, Dept Hlth Rehabil, Shaqra 11961, Saudi Arabia.
EM ajithsoman@su.edu.sa
RI Ramamoorthy, Baranitharan/ABF-7860-2021; Soman, Ajith/GQH-6622-2022;
   Alqahtani, Bijad/GVS-7621-2022; Alkhathami, Khalid/ABC-6655-2021
OI Soman, Ajith/0000-0001-9890-2552; Alqahtani, Bijad/0000-0001-7887-0979;
   Ramamoorthy, Baranitharan/0000-0002-4189-7307; Alkhathami,
   Khalid/0000-0002-7630-5471
FU Deputyship for Research and Innovation, Ministry of Education in KSA
   [IFP2021-071]
FX Source of funding The authors extend their appreciation to the
   Deputyship for Research and Innovation, Ministry of Education in KSA for
   funding this research work through project number IFP2021-071.
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NR 50
TC 3
Z9 3
U1 0
U2 3
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1658-3612
J9 J TAIBAH UNIV MED SC
JI J. Taibah Univ. Med. Soc.
PD OCT
PY 2023
VL 18
IS 5
BP 917
EP 925
DI 10.1016/j.jtumed.2023.01.009
EA FEB 2023
PG 9
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA 9O9SQ
UT WOS:000943934500001
PM 36852342
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Kutbi, HA
   Hammouda, SA
AF Kutbi, Hebah Alawi
   Hammouda, Sahar Ali
TI Plasma concentrations of vitamin A and E and risk of dysglycemia in
   first-trimester pregnant Saudi women
SO DIABETOLOGY & METABOLIC SYNDROME
LA English
DT Article
DE Vitamin A; Vitamin E; Antioxidant; Glycemic control
ID OXIDATIVE STRESS; ANTIOXIDANT SUPPLEMENTATION; DIABETES-MELLITUS;
   METABOLIC SYNDROME; PREVALENCE; TRENDS; IMPACT
AB Background Existing evidence suggest that low concentrations of vitamin A and E may have a contribution to the development of diabetes complications; however, data regarding the status of vitamin A and E among individuals with prediabetes are lacking. This study aimed to examine the association of plasma concentrations of vitamin A and E with the glycemic control status among first trimester pregnant Saudi women. Methods In this cross-sectional study, 1102 first trimester pregnant Saudi women were recruited from antenatal clinics. Sociodemographic and anthropometric information were collected, and laboratory analyses of blood glycated hemoglobin (A1C) and plasma vitamins A and E were performed. Subjects were classified as normoglycemic, prediabetic, or undiagnosed diabetic. Multinomial regression models adjusted for age estimated the adjusted odds ratios (aORs) and [95% confidence intervals (CIs)]. Results Among the sample, 78.8% (n = 868) had normal glycemic control, while 19.1% (n = 211) had prediabetes and 2.1% (n = 23) had undiagnosed diabetes. Plasma concentrations of vitamin A and E of prediabetic participants were at a level midway between that of normoglycemic and diabetic participants (p < 0.01). Compared to subjects with normoglycemic status, those with higher concentrations of vitamin A and E had lower odds of being prediabetic (aOR = 0.27 [0.21-0.35] and aOR = 0.95 [0.94-0.96], respectively) or diabetic (aOR = 0.18 [0.13-0.24] and aOR = 0.93 [0.92-0.94], respectively). Conclusions Our findings indicate a possible contribution of vitamins A and E to the progression of prediabetes to diabetes. Future longitudinal studies are needed to elucidate the association between the antioxidant status and dysglycemia. Clinicians should monitor the glycemic and the antioxidant status closely and provide dietary guidance where needed.
C1 [Kutbi, Hebah Alawi] King Abdulaziz Univ, Fac Appl Med Sci, Dept Clin Nutr, Jeddah 21589, Saudi Arabia.
   [Hammouda, Sahar Ali] Taibah Univ, Coll Appl Med Sci, Dept Clin Nutr, Al Madinah Al Monawarah, Saudi Arabia.
C3 King Abdulaziz University; Taibah University
RP Kutbi, HA (corresponding author), King Abdulaziz Univ, Fac Appl Med Sci, Dept Clin Nutr, Jeddah 21589, Saudi Arabia.
EM hkutbi@kau.edu.sa
RI Kutbi, Hebah/AAC-5930-2019
OI Kutbi, Hebah/0000-0002-2687-2515
FU King Abdulaziz City for Science and Technology (KACST), Saudi Arabia
   [AT-28-113]
FX Funding for this project was provided by King Abdulaziz City for Science
   and Technology (KACST), Saudi Arabia by Grant Number AT-28-113.
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NR 38
TC 3
Z9 4
U1 0
U2 3
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1758-5996
J9 DIABETOL METAB SYNDR
JI Diabetol. Metab. Syndr.
PD FEB 18
PY 2020
VL 12
IS 1
AR 17
DI 10.1186/s13098-020-00525-3
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA KQ9HR
UT WOS:000517232300001
PM 32095162
OA Green Published, gold
DA 2025-06-11
ER

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AF Anderson, Michaela R.
   Udupa, Jayaram K.
   Edwin, Ethan
   Diamond, Joshua M.
   Singer, Jonathan P.
   Kukreja, Jasleen
   Hays, Steven R.
   Greenland, John R.
   Ferrante, Anthony, Jr.
   Lippel, Matthew
   Blue, Tatiana
   McBurnie, Amika
   Oyster, Michelle
   Kalman, Laurel
   Rushefski, Melanie
   Wu, Caiyun
   Pednekar, Gargi
   Liu, Wen
   Arcasoy, Selim
   Sonett, Joshua
   D'Ovidio, Frank
   Bacchetta, Matthew
   Newell, John D., Jr.
   Torigian, Drew
   Cantu, Edward
   Farber, Donna L.
   Giles, Jon T.
   Tong, Yubing
   Palmer, Scott
   Ware, Lorraine B.
   Hancock, Wayne W.
   Christie, Jason D.
   Lederer, David J.
TI Adipose tissue quantification and primary graft dysfunction after lung
   transplantation: The Lung Transplant Body Composition study
SO JOURNAL OF HEART AND LUNG TRANSPLANTATION
LA English
DT Article
DE adipose tissue; primary graft dysfunction; lung transplantation;
   obesity; inflammation
ID INTERLEUKIN-1 RECEPTOR ANTAGONIST; VISCERAL ABDOMINAL FAT; MASS INDEX;
   RISK-FACTORS; LIPID-PEROXIDATION; METABOLIC SYNDROME; OXIDATIVE STRESS;
   PERICARDIAL FAT; UP-REGULATION; OBESITY
AB BACKGROUND: Obesity is associated with an increased risk of primary graft dysfunction (PGD) after lung transplantation. The contribution of specific adipose tissue depots is unknown.
   METHODS: We performed a prospective cohort study of adult lung transplant recipients at 4 U.S. transplant centers. We measured cross-sectional areas of subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) on chest and abdominal computed tomography (CT) scans and indexed each measurement to height.(2) We used logistic regression to examine the associations of adipose indices and adipose classes with grade 3 PGD at 48 or 72 hours, and Cox proportional hazards models to examine survival. We used latent class analyses to identify the patterns of adipose distribution. We examined the associations of adipose indices with plasma biomarkers of obesity and PGD.
   RESULTS: A total of 262 and 117 subjects had available chest CT scans and underwent protocol abdominal CT scans, respectively. In the adjusted models, a greater abdominal SAT index was associated with an increased risk of PGD (odds ratio 1.9, 95% CI 1.02- 3.4, p = 0.04) but not with survival time. VAT indices were not associated with PGD risk or survival time. A greater abdominal SAT index correlated with greater pre- and post-transplant leptin (r = 0.61, p < 0.001, and r = 0.44, p < 0.001), pre-transplant IL-1RA (r = 0.25, p = 0.04), and post-transplant ICAM-1 (r = 0.25, p = 0.04). We identified 3 latent patterns of adiposity. The class defined by high thoracic and abdominal SAT had the greatest risk of PGD.
   CONCLUSIONS: Subcutaneous, but not visceral, adiposity is associated with an increased risk of PGD after lung transplantation. (C) 2019 International Society for Heart and Lung Transplantation. All rights reserved.
C1 [Anderson, Michaela R.; Lippel, Matthew; Blue, Tatiana; McBurnie, Amika; Liu, Wen; Arcasoy, Selim; Giles, Jon T.; Lederer, David J.] Columbia Univ, Dept Med, Med Ctr, New York, NY 10032 USA.
   [Udupa, Jayaram K.; Wu, Caiyun; Pednekar, Gargi; Torigian, Drew; Tong, Yubing] Univ Penn, Dept Radiol, Philadelphia, PA 19104 USA.
   [Edwin, Ethan; Ferrante, Anthony, Jr.] Columbia Univ, Columbia Inst Human Nutr, Med Ctr, New York, NY 10032 USA.
   [Diamond, Joshua M.; Oyster, Michelle; Kalman, Laurel; Rushefski, Melanie; Christie, Jason D.] Univ Penn, Dept Med, Philadelphia, PA 19104 USA.
   [Singer, Jonathan P.; Hays, Steven R.; Greenland, John R.] Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA.
   [Kukreja, Jasleen; Farber, Donna L.] Univ Calif San Francisco, Dept Surg, San Francisco, CA USA.
   [Sonett, Joshua; D'Ovidio, Frank] Columbia Univ, Dept Surg, Med Ctr, New York, NY 10032 USA.
   [Bacchetta, Matthew] Vanderbilt Univ, Med Ctr, Dept Thorac Surg, Nashville, TN USA.
   [Newell, John D., Jr.] Univ Iowa, Dept Radiol, Iowa City, IA 52242 USA.
   [Cantu, Edward] Univ Penn, Dept Surg, Philadelphia, PA 19104 USA.
   [Farber, Donna L.] Columbia Univ, Columbia Ctr Translat Immunol, Med Ctr, New York, NY 10032 USA.
   [Farber, Donna L.] Columbia Univ, Dept Microbiol & Immunol, Med Ctr, New York, NY 10032 USA.
   [Palmer, Scott] Duke Univ, Dept Med, Durham, NC USA.
   [Palmer, Scott] Duke Clin Res Inst, Durham, NC USA.
   [Ware, Lorraine B.] Vanderbilt Univ, Med Ctr, Dept Med, Nashville, TN USA.
   [Hancock, Wayne W.] Univ Penn, Dept Pathol & Lab Med, Philadelphia, PA USA.
   [Lederer, David J.] Columbia Univ, Mailman Sch Publ Hlth, Dept Epidemiol, Med Ctr, New York, NY 10032 USA.
C3 Columbia University; University of Pennsylvania; Columbia University;
   University of Pennsylvania; University of California System; University
   of California San Francisco; University of California System; University
   of California San Francisco; Columbia University; Vanderbilt University;
   University of Iowa; University of Pennsylvania; Columbia University;
   Columbia University; Duke University; Duke University; Vanderbilt
   University; University of Pennsylvania; Columbia University
RP Lederer, DJ (corresponding author), Columbia Univ, Med Ctr, Room 3-321A,161 Ft Washington Ave, New York, NY 10032 USA.
EM davidlederer@columbia.edu
RI Farber, Donna/HSC-6967-2023; Arcasoy, Selim/AAR-6637-2020; Bacchetta,
   Matthew/KLC-4894-2024; Lederer, David/W-7957-2018; Greenland,
   John/AAR-6030-2021; Singer, Jonathan/AAS-6581-2020; Ware,
   Lorraine/KPB-7924-2024; Ferrante, Anthony/AAC-7763-2019
OI Palmer, Scott/0000-0002-1370-3771; Bacchetta,
   Matthew/0000-0003-4456-4484; Greenland, John/0000-0003-1422-8367; Ware,
   Lorraine/0000-0002-9429-4702; Christie, Jason/0000-0003-0519-218X;
   D'Ovidio, Frank/0000-0003-1678-2345; Ferrante,
   Anthony/0000-0001-9272-2593; Giles, Jon/0000-0002-8792-0402; Pednekar,
   Gargi/0000-0002-4734-9598
FU National Institutes of Health/National Heart, Lung, and Blood Institute
   [R01 HL114626, R01 HL087115, K24 HL115354, K24 HL 131937, K23 HL121406,
   K23 HL111115, T32 HL105323, K23 HL 116656, R03 HL135227, R01 DK066525,
   T32 DK07328, R01 HL134851]; VA ORD [IK2 CX001034]; Stony-Wold Herbert
   Foundation;  [AMFDP 70640]; National Heart Lung and Blood Institute
   [R01HL134851] Funding Source: NIH RePORTER
FX The authors have no conflicts of interest to disclose. This study was
   supported by National Institutes of Health/National Heart, Lung, and
   Blood Institute grants R01 HL114626, R01 HL087115, K24 HL115354, K24 HL
   131937, K23 HL121406, K23 HL111115, T32 HL105323, K23 HL 116656, R03
   HL135227, R01 DK066525, T32 DK07328, R01 HL134851, and VA ORD IK2
   CX001034, and by Robert Woods Johnson AMFDP 70640 and the Stony-Wold
   Herbert Foundation.
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NR 70
TC 30
Z9 31
U1 0
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1053-2498
EI 1557-3117
J9 J HEART LUNG TRANSPL
JI J. Heart Lung Transplant.
PD DEC
PY 2019
VL 38
IS 12
BP 1246
EP 1256
DI 10.1016/j.healun.2019.08.013
PG 11
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery;
   Transplantation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery;
   Transplantation
GA JQ0PZ
UT WOS:000498658400002
PM 31474492
OA Green Accepted, Green Submitted
DA 2025-06-11
ER

PT J
AU Mu, L
   Li, R
   Lai, Y
   Zhao, Y
   Qiao, J
AF Mu, L.
   Li, R.
   Lai, Y.
   Zhao, Y.
   Qiao, J.
TI Adipose insulin resistance is associated with cardiovascular risk
   factors in polycystic ovary syndrome
SO JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
LA English
DT Article
DE Polycystic ovary syndrome; Adipose tissue; Insulin resistance; Metabolic
   syndrome
ID GLUCOSE-PRODUCTION; INFLAMMATION; PREVALENCE; OBESE; PATHOPHYSIOLOGY;
   SENSITIVITY; STRESS; WOMEN
AB PurposeThe effects of adipose insulin resistance on cardiovascular risk factors in polycystic ovary syndrome (PCOS) remain largely unknown. We aimed to investigate associations between adipose insulin resistance and cardiovascular risk factors in PCOS.MethodsA total of 207 PCOS and 47 non-PCOS women were recruited from a large reproductive medicine center in this cross-sectional study. The PCOS diagnosis was based on the Rotterdam Criteria. The subjects received a standard oral glucose tolerance test. Adipose insulin resistance was evaluated using a validated index (adipose-IR=fasting insulinxfree fatty acid concentrations).ResultsThe women with PCOS showed a higher adipose-IR index, and the adipose-IR index was tightly associated with the blood pressure, glucose and lipid parameters. A total of 98.0% of the women with PCOS in the highest adipose-IR quartile showed cardiovascular risk factors (obesity, hypertension, glucose intolerance or dyslipidemia), and this percentage was significantly higher than the percentage of those in the lowest quartile (32.7%). In addition, the percentages of women with three (31.4%) and four (13.7%) cardiovascular risk factors were significantly elevated in the highest adipose-IR quartile. The multivariable logistic regression analysis indicated that each 1-SD increment in the adipose-IR index resulted in higher risks of obesity (OR=3.18, 95% CI=2.12-4.76), hypertension (OR=1.89, 95% CI=1.31-2.73), glucose intolerance (OR=2.45, 95% CI=1.73-3.48), and dyslipidemia (OR=2.18, 95% CI=1.57-3.01). The C-reactive protein (CRP) level was positively associated with the adipose-IR index in women with PCOS (r=0.45, P<0.001).ConclusionsThe adipose-IR index was associated with cardiovascular risk factors in women with PCOS. Chronic inflammation may induce insulin resistance in the adipose tissue of women with PCOS.
C1 [Mu, L.; Li, R.; Lai, Y.; Zhao, Y.; Qiao, J.] Peking Univ, Dept Obstet & Gynecol, Ctr Reprod Med, Hosp 3, 49 North HuaYuan Rd, Beijing 100191, Peoples R China.
   [Mu, L.; Li, R.; Zhao, Y.; Qiao, J.] Natl Clin Res Ctr Obstet & Gynecol, Beijing 100191, Peoples R China.
   [Mu, L.; Li, R.; Qiao, J.] Beijing Key Lab Reprod Endocrinol & Assisted Repr, Beijing 100191, Peoples R China.
   [Mu, L.; Zhao, Y.; Qiao, J.] Minist Educ, Key Lab Assisted Reprod, Beijing 100191, Peoples R China.
   [Lai, Y.; Qiao, J.] Peking Univ, Peking Tsinghua Ctr Life Sci, Beijing 100871, Peoples R China.
C3 Peking University; Ministry of Education - China; Peking University
RP Zhao, Y (corresponding author), Peking Univ, Dept Obstet & Gynecol, Ctr Reprod Med, Hosp 3, 49 North HuaYuan Rd, Beijing 100191, Peoples R China.; Zhao, Y (corresponding author), Natl Clin Res Ctr Obstet & Gynecol, Beijing 100191, Peoples R China.; Zhao, Y (corresponding author), Minist Educ, Key Lab Assisted Reprod, Beijing 100191, Peoples R China.
EM zhaoyue0630@163.com; jie.qiao@263.net
FU National Key Research and Development Program of China [2017YFC1001003,
   2016YFC1000201]; National Natural Science Foundation of China [81671419,
   81471427]
FX This study was supported by the National Key Research and Development
   Program of China (2017YFC1001003, 2016YFC1000201) and the National
   Natural Science Foundation of China (81671419, 81471427).
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NR 36
TC 20
Z9 23
U1 0
U2 12
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0391-4097
EI 1720-8386
J9 J ENDOCRINOL INVEST
JI J. Endocrinol. Invest.
PD MAY
PY 2019
VL 42
IS 5
BP 541
EP 548
DI 10.1007/s40618-018-0949-2
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA HZ0KB
UT WOS:000468528400006
PM 30206805
DA 2025-06-11
ER

PT J
AU Yanai, H
   Yoshida, H
AF Yanai, Hidekatsu
   Yoshida, Hiroshi
TI Beneficial Effects of Adiponectin on Glucose and Lipid Metabolism and
   Atherosclerotic Progression: Mechanisms and Perspectives
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE adiponectin; atherosclerosis; cholesterol efflux; diabetes; inflammation
ID TYPE-2 DIABETES-MELLITUS; HIGH-DENSITY-LIPOPROTEIN; MOLECULAR-WEIGHT
   ADIPONECTIN; PLASMA ADIPOKINES CONCENTRATIONS; ENDOTHELIAL ADHESION
   MOLECULES; INCREASING CHOLESTEROL EFFLUX; CARDIOVASCULAR RISK-FACTORS;
   VITAMIN-D SUPPLEMENTATION; HEPATIC LIPASE ACTIVITY; FATTY-ACID OXIDATION
AB Circulating adiponectin concentrations are reduced in obese individuals, and this reduction has been proposed to have a crucial role in the pathogenesis of atherosclerosis and cardiovascular diseases associated with obesity and the metabolic syndrome. We focus on the effects of adiponectin on glucose and lipid metabolism and on the molecular anti-atherosclerotic properties of adiponectin and also discuss the factors that increase the circulating levels of adiponectin. Adiponectin reduces inflammatory cytokines and oxidative stress, which leads to an improvement of insulin resistance. Adiponectin-induced improvement of insulin resistance and adiponectin itself reduce hepatic glucose production and increase the utilization of glucose and fatty acids by skeletal muscles, lowering blood glucose levels. Adiponectin has also cell protective effects and may prevent the development of diabetes. Adiponectin concentration has been found to be correlated with lipoprotein metabolism; especially, it is associated with the metabolism of high-density lipoprotein (HDL) and triglyceride (TG). Adiponectin appears to increase HDL and decrease TG. Adiponectin increases ATP-binding cassette transporter A1 and lipoprotein lipase (LPL) and decreases hepatic lipase, which may elevate HDL. Increased LPL mass/activity and very low density lipoprotein (VLDL) receptor and reduced apo-CIII may increase VLDL catabolism and result in the reduction of serum TG. Further, adiponectin has various molecular anti-atherosclerotic properties, such as reduction of scavenger receptors in macrophages and increase of cholesterol efflux. These findings suggest that high levels of circulating adiponectin can protect against atherosclerosis. Weight loss, exercise, nutritional factors, anti-diabetic drugs, lipid-lowering drugs, and anti-hypertensive drugs have been associated with an increase of serum adiponectin level.
C1 [Yanai, Hidekatsu] Kohnodai Hosp, Dept Internal Med, Natl Ctr Global Hlth & Med, 1-7-1 Kohnodai, Chiba 2728516, Japan.
   [Yoshida, Hiroshi] Jikei Univ, Dept Lab Med, Kashiwa Hosp, 163-1 Kashiwashita, Kashiwa, Chiba 2778567, Japan.
C3 Japan Institute for Health Security (JIHS); National Center for Global
   Health & Medicine - Japan; Jikei University
RP Yanai, H (corresponding author), Kohnodai Hosp, Dept Internal Med, Natl Ctr Global Hlth & Med, 1-7-1 Kohnodai, Chiba 2728516, Japan.; Yoshida, H (corresponding author), Jikei Univ, Dept Lab Med, Kashiwa Hosp, 163-1 Kashiwashita, Kashiwa, Chiba 2778567, Japan.
EM dyanai@hospk.ncgm.go.jp; hyoshida@jikei.ac.jp
RI Yanai, Hidekatsu/AFN-9517-2022
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NR 187
TC 327
Z9 351
U1 11
U2 96
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD MAR 1
PY 2019
VL 20
IS 5
AR 1190
DI 10.3390/ijms20051190
PG 25
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA HQ6QE
UT WOS:000462542300189
PM 30857216
OA Green Published, Green Submitted, gold
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Veronese, N
   Sigeirsdottir, K
   Eiriksdottir, G
   Marques, EA
   Chalhoub, D
   Phillips, CL
   Launer, LJ
   Maggi, S
   Gudnason, V
   Harris, TB
AF Veronese, Nicola
   Sigeirsdottir, Kristin
   Eiriksdottir, Gudny
   Marques, Elisa A.
   Chalhoub, Didier
   Phillips, Caroline L.
   Launer, Lenore J.
   Maggi, Stefania
   Gudnason, Vilmundur
   Harris, Tamara B.
TI Frailty and Risk of Cardiovascular Diseases in Older Persons: The Age,
   Gene/Environment Susceptibility-Reykjavik Study
SO REJUVENATION RESEARCH
LA English
DT Article
DE cardiovascular disease; risk factor; aging; frailty
ID CORONARY-HEART-DISEASE; MYOCARDIAL-INFARCTION; OXIDATIVE STRESS; WOMENS
   HEALTH; WALKING SPEED; TASK-FORCE; ADULTS; MEN; ATHEROSCLEROSIS;
   METAANALYSIS
AB Frailty is a risk factor for cardiovascular diseases (CVD), but the studies available have not considered the presence of subclinical atherosclerotic disease as potential confounders. We investigated the association between frailty and the onset of CVD independently of subclinical atherosclerotic disease. For this reason, a sample of 3818 older participants participating in the Age, Gene/Environment SusceptibilityReykjavik Study without CVD at baseline was followed for a median of 8.7 years. Frailty was defined as the presence of 3 among five Fried's criteria (unintentional weight loss, low physical activity level, weakness, exhaustion, and slow gait speed). Incident CVD was defined as onset of coronary artery disease, heart failure, stroke, and CVD-related mortality identified using hospital, medical, and death records. Subclinical atherosclerotic disease was evaluated as the maximum value of carotid intima media thickness, presence of carotid plaque (moderate or high), and total coronary calcifications (CACs). At baseline, frail participants (n=300) were more frequently obese, diabetic, and had a greater presence of metabolic syndrome than the nonfrail (n=3518). Frail participants also showed a higher presence of carotid plaques and CACs. Using a Cox's regression analysis, adjusted for clinical, biochemical, and subclinical atherosclerosis estimates, frailty increased the risk of CVD (hazard ratio [HR]=1.35; 95% confidence interval [CI]: 1.05-1.74), with results stronger for women than men (HR=1.51, p=0.006 and 1.19, p=0.44, respectively). Among Fried's criteria, exhaustion was the only criterion significantly associated with the onset of new CVD events (HR=1.30; 95% CI: 1.00-1.73). In conclusion, frailty was associated with the onset of CVD in older people even after adjusting for subclinical atherosclerotic disease.
C1 [Veronese, Nicola; Maggi, Stefania] CNR, Neurosci Inst, Aging Branch, Padua, Italy.
   [Sigeirsdottir, Kristin; Eiriksdottir, Gudny; Gudnason, Vilmundur] Iceland Heart Assoc, Kopavogur, Iceland.
   [Marques, Elisa A.; Chalhoub, Didier; Phillips, Caroline L.; Launer, Lenore J.; Harris, Tamara B.] NIA, Lab Epidemiol & Populat Sci, Bethesda, MD 20892 USA.
   [Gudnason, Vilmundur] Univ Iceland, Sch Med, Reykjavik, Iceland.
C3 Consiglio Nazionale delle Ricerche (CNR); Icelandic Heart Association;
   National Institutes of Health (NIH) - USA; NIH National Institute on
   Aging (NIA); University of Iceland
RP Veronese, N (corresponding author), CNR, Neurosci Inst, Aging Branch, DIMED, Via Giustiniani 2, I-35128 Padua, Italy.
EM ilmannato@gmail.com
RI Veronese, Nicola/K-4343-2018; Marques, Elisa/GXV-6133-2022; Gudnason,
   Vilmundur/AAE-7126-2019; Gudnason, Vilmundur/K-6885-2015
OI Gudnason, Vilmundur/0000-0001-5696-0084; Marques,
   Elisa/0000-0002-6969-6830
FU National Institutes of Health [N01-AG-12100]; National Institute on
   Aging Intramural Research Program, Hjartavernd (the Icelandic Heart
   Association); Althingi (the Icelandic Parliament); Intramural Research
   Program of the National Institutes of Health, National Institute on
   Aging
FX This work was supported by National Institutes of Health (N01-AG-12100),
   the National Institute on Aging Intramural Research Program, Hjartavernd
   (the Icelandic Heart Association), and the Althingi (the Icelandic
   Parliament). E.A.M., D.C., L.J.L., and T.B.H. were supported, in part,
   by the Intramural Research Program of the National Institutes of Health,
   National Institute on Aging.
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NR 38
TC 66
Z9 68
U1 0
U2 21
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1549-1684
EI 1557-8577
J9 REJUV RES
JI Rejuv. Res.
PD DEC
PY 2017
VL 20
IS 6
BP 517
EP 524
DI 10.1089/rej.2016.1905
PG 8
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA FQ3EZ
UT WOS:000418241300008
PM 28602121
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Schinzari, F
   Veneziani, A
   Mores, N
   Barini, A
   Di Daniele, N
   Cardillo, C
   Tesauro, M
AF Schinzari, Francesca
   Veneziani, Augusto
   Mores, Nadia
   Barini, Angela
   Di Daniele, Nicola
   Cardillo, Carmine
   Tesauro, Manfredi
TI Beneficial Effects of Apelin on Vascular Function in Patients With
   Central Obesity
SO HYPERTENSION
LA English
DT Article
DE angiotensin II; endothelin-1; insulin; obesity; vasodilation
ID INSULIN-RESISTANT MICE; NITRIC-OXIDE ACTIVITY; METABOLIC SYNDROME;
   HEART-FAILURE; OXIDATIVE STRESS; ANG-II; SYSTEM; HYPERINSULINEMIA;
   RECEPTOR; ENDOTHELIN-1
AB Patients with central obesity have impaired insulin-stimulated vasodilation and increased ET-1 (endothelin 1) vasoconstriction, which may contribute to insulin resistance and vascular damage. Apelin enhances insulin sensitivity and glucose disposal but also acts as a nitric oxide (NO)-dependent vasodilator and a counter-regulator of AT 1 (angiotensin [Ang] II type 1) receptor-induced vasoconstriction. We, therefore, examined the effects of exogenous (Pyr1) apelin on NO-mediated vasodilation and Ang II-or ET-1-dependent vasoconstrictor tone in obese patients. In the absence of hyperinsulinemia, forearm blood flow responses to graded doses of acetylcholine and sodium nitroprusside were not different during saline or apelin administration (both P>0.05). During intra-arterial infusion of regular insulin, however, apelin enhanced the vasodilation induced by both acetylcholine and nitroprusside (both P<0.05). Interestingly, the vasodilator effect of concurrent blockade of AT 1 (telmisartan) and AT 2 (PD 123,319) receptors was blunted by apelin (3 +/- 5% versus 32 +/- 9%; P<0.05). Similarly, during apelin administration, blockade of ET A receptors (BQ-123) resulted in lower vasodilator response than during saline (23 +/- 10% versus 65 +/- 12%; P< 0.05). NO synthase inhibition by L-NMMA (L-N-monometylarginine) during the concurrent blockade of either Ang II or ET A receptors resulted in similar vasoconstriction in the absence or presence of apelin (P>0.05). In conclusion, in patients with central obesity, apelin has favorable effects not only to improve insulin-stimulated endothelium-dependent and endothelium-independent vasodilator responses but also to blunt Ang II-and ET-1-dependent vasoconstriction by a mechanism not involving NO. Taken together, our results suggest that targeting the apelin system might favorably impact some hemodynamic abnormalities of insulin-resistant states like obesity.
C1 [Schinzari, Francesca; Cardillo, Carmine] Catholic Univ, Dept Internal Med, Rome, Italy.
   [Veneziani, Augusto] Catholic Univ, Dept Surg, Rome, Italy.
   [Mores, Nadia] Catholic Univ, Dept Pharmacol, Rome, Italy.
   [Barini, Angela] Catholic Univ, Dept Biochem, Rome, Italy.
   [Di Daniele, Nicola; Tesauro, Manfredi] Univ Tor Vergata, Dept Internal Med, Rome, Italy.
C3 Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli;
   Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli;
   Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli;
   Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli;
   University of Rome Tor Vergata
RP Cardillo, C (corresponding author), Univ Cattolica Sacro Cuore, Ist Patol Speciale Med & Semeiot Med, Largo Gemelli 8, I-00168 Rome, Italy.
EM carmine.cardillo@unicatt.it
RI schinzari, francesca/AAB-9982-2019
OI Cardillo, Carmine/0000-0001-5182-3005
FU Ministero della Salute [RF-2010-2313809]; Fondazione Roma
   [NCDS-2013-00000308]; Fondi d'Ateneo grants from the Universita
   Cattolica
FX This work was supported by a grant from the Ministero della Salute
   (RF-2010-2313809) and by a grant from the Fondazione Roma
   (NCDS-2013-00000308) to C. Cardillo, who is also supported by Fondi
   d'Ateneo grants from the Universita Cattolica. M. Tesauro and N. Di
   Daniele are both supported by grants from the Fondazione Roma.
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NR 44
TC 24
Z9 26
U1 0
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0194-911X
EI 1524-4563
J9 HYPERTENSION
JI Hypertension
PD MAY
PY 2017
VL 69
IS 5
BP 942
EP 949
DI 10.1161/HYPERTENSIONAHA.116.08916
PG 8
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA ES1YV
UT WOS:000399323800032
PM 28289180
DA 2025-06-11
ER

PT J
AU Harder-Lauridsen, NM
   Nielsen, ST
   Mann, SP
   Lyngbk, MP
   Benatti, FB
   Langkilde, AR
   Law, I
   Wedell-Neergaard, AS
   Thomsen, C
   Moller, K
   Karstoft, K
   Pedersen, BK
   Krogh-Madsen, R
AF Harder-Lauridsen, Nina Majlund
   Nielsen, Signe Tellerup
   Mann, Sebastian Porsdam
   Lyngbk, Mark Preben
   Benatti, Fabiana Braga
   Langkilde, Annika Reynberg
   Law, Ian
   Wedell-Neergaard, Anne-Sophie
   Thomsen, Carsten
   Moller, Kirsten
   Karstoft, Kristian
   Pedersen, Bente Klarlund
   Krogh-Madsen, Rikke
TI The effect of alternate-day caloric restriction on the metabolic
   consequences of 8 days of bed rest in healthy lean men: a randomized
   trial
SO JOURNAL OF APPLIED PHYSIOLOGY
LA English
DT Article
DE alternate-day fasting; inactivity; visceral fat mass; oral glucose
   tolerance test; clinical; metabolism; cognitive performance
ID TYPE-2 DIABETIC-PATIENTS; VISCERAL ADIPOSE-TISSUE; HIGH-FAT DIET;
   PHYSICAL INACTIVITY; OXIDATIVE STRESS; NEURAL SYSTEMS; WEIGHT-LOSS;
   RESPONSES; EXERCISE; GLUCOSE
AB Physical activity and alternate-day fasting/caloric restriction may both ameliorate aspects of the metabolic syndrome, such as insulin resistance, visceral fat mass accumulation, and cognitive impairment by overlapping mechanisms. The purpose of this study was to test the hypothesis that alternate-day caloric restriction (ADCR) with overall energy balance would reduce insulin resistance and accumulation of visceral fat, in addition to improving cognitive functions, after 8 consecutive days in bed. Healthy, lean men (n = 20) were randomized to 1) 8 days of bed rest with three daily isoenergetic meals (control group, n = 10); and 2) 8 days of bed rest with 25% of total energy requirements every other day and 175% of total energy requirements every other day (ADCR group). Oral glucose tolerance testing, dual-energy X-ray absorptiometry (DXA) scans, magnetic resonance imaging of the abdomen and brain, VO2max, and tests for cognitive function were performed before and after bed rest. In addition, daily fasting blood samples and 24-h glucose profiles by continuous glucose monitoring system were assessed during the 8 days of bed rest period. Bed rest induced insulin resistance, visceral fat accumulation, and worsening of mood. No positive effects emerged from ADCR on these negative health outcomes. Compared with the control group, ADCR was associated with improved and steadier glycemic control on fasting days and higher glycemic fluctuation and indexes of insulin resistance on overeating days. In contrast to our hypothesis, the metabolic impairment induced by 8 days of bed rest was not counteracted by ADCR with overall energy balance.
   NEW & NOTEWORTHY Alternate-day caloric restriction without overall energy reduction does not ameliorate the metabolic impairment induced in lean men by 8 days of bed rest.
C1 [Harder-Lauridsen, Nina Majlund; Nielsen, Signe Tellerup; Lyngbk, Mark Preben; Wedell-Neergaard, Anne-Sophie; Karstoft, Kristian; Pedersen, Bente Klarlund; Krogh-Madsen, Rikke] Univ Copenhagen, Ctr Inflammat & Metab, Rigshosp, Copenhagen, Denmark.
   [Harder-Lauridsen, Nina Majlund; Nielsen, Signe Tellerup; Lyngbk, Mark Preben; Wedell-Neergaard, Anne-Sophie; Karstoft, Kristian; Pedersen, Bente Klarlund; Krogh-Madsen, Rikke] Univ Copenhagen, Ctr Phys Act Res, Rigshosp, Copenhagen, Denmark.
   [Mann, Sebastian Porsdam] Harvard Med Sch, Ctr Bioeth, Boston, MA USA.
   [Benatti, Fabiana Braga] Univ Sao Paulo, Appl Physiol & Nutr Res Grp, Sao Paulo, Brazil.
   [Langkilde, Annika Reynberg; Thomsen, Carsten] Rigshosp, Dept Diagnost Sci, Copenhagen, Denmark.
   [Law, Ian] Rigshosp, Dept Clin Physiol Nucl Med & PET, Copenhagen, Denmark.
   [Moller, Kirsten] Univ Copenhagen, Dept Neuroanaesthesiol, Rigshosp, Copenhagen, Denmark.
C3 University of Copenhagen; Copenhagen University Hospital;
   Rigshospitalet; Rigshospitalet; University of Copenhagen; Copenhagen
   University Hospital; Harvard University; Harvard Medical School;
   Universidade de Sao Paulo; Rigshospitalet; University of Copenhagen;
   Copenhagen University Hospital; Rigshospitalet; University of
   Copenhagen; Copenhagen University Hospital; Rigshospitalet; University
   of Copenhagen; Copenhagen University Hospital
RP Harder-Lauridsen, NM (corresponding author), Ctr Inflammat & Metab, Rigshosp 7641, DK-2100 Copenhagen, Denmark.; Harder-Lauridsen, NM (corresponding author), Ctr Phys Act Res CFAS, Blegdamsvej 9, DK-2100 Copenhagen, Denmark.
EM nmharder@gmail.com
RI Krogh-Madsen, Rikke/JOK-7442-2023; Pedersen, Bente/AGR-3217-2022;
   Lyngbaek, Mark/AAM-3899-2020; Karstoft, Kristian/MIT-1634-2025; Moller,
   Kirsten/A-4751-2009; Benatti, Fabiana/H-7167-2016
OI Law, Ian/0000-0001-9644-7496; Printz Lyngbaek, Mark
   Preben/0000-0002-1931-9658; Krogh-Madsen, Rikke/0000-0003-4914-2715;
   Moller, Kirsten/0000-0003-3058-1072; Harder-Lauridsen, Nina
   M./0000-0002-8651-5544; Benatti, Fabiana/0000-0002-8320-7044; Karstoft,
   Kristian/0000-0002-6596-4199; Pedersen, Bente
   Klarlund/0000-0001-6508-6288
FU TrygFonden; Danish National Research Foundation [DNRF55]; Augustinus
   Foundation; Aase and Ejnar Danielsen's Foundation; Danish Council for
   Strategic Research Grant [09-067009, 09-075724]
FX The Centre for Physical Activity Research (CFAS) is supported by a grant
   from TrygFonden. During the study period, the Centre of Inflammation and
   Metabolism (CIM) was supported by a grant from the Danish National
   Research Foundation (DNRF55). This study was further supported by grants
   from The Augustinus Foundation (RK-M) and Aase and Ejnar Danielsen's
   Foundation (STN). CIM/CFAS is a member of DD2-the Danish Center for
   Strategic Research in Type 2 Diabetes (Danish Council for Strategic
   Research Grant 09-067009 and 09-075724).
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NR 52
TC 18
Z9 20
U1 0
U2 9
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 8750-7587
EI 1522-1601
J9 J APPL PHYSIOL
JI J. Appl. Physiol.
PD FEB
PY 2017
VL 122
IS 2
BP 230
EP 241
DI 10.1152/japplphysiol.00846.2016
PG 12
WC Physiology; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology; Sport Sciences
GA EN2GY
UT WOS:000395829200002
PM 27881670
DA 2025-06-11
ER

PT J
AU Cazeau, RM
   Rauch, L
   Huang, H
   Bauer, JA
   Hoffman, RP
AF Cazeau, Rachel-Marie
   Rauch, Lindsey
   Huang, Hong
   Bauer, John A.
   Hoffman, Robert P.
TI Increased Pre- and Post-Meal Free Fatty Acid Levels in Black, Obese
   Adolescents
SO METABOLIC SYNDROME AND RELATED DISORDERS
LA English
DT Article
ID C-REACTIVE PROTEIN; SYMPATHETIC NEURAL ACTIVATION; METABOLIC SYNDROME;
   ENDOTHELIAL FUNCTION; OXIDATIVE STRESS; AFRICAN-AMERICAN; POSTPRANDIAL
   HYPERTRIGLYCERIDEMIA; INSULIN-RESISTANCE; SEX-DIFFERENCES; HEALTHY
AB Background: Black adolescents are at increased risk of cardiometabolic disease but have lower fasting triglyceride, which is usually associated with decreased risk. No one has studied racial differences in triglycerides or free fatty acids (FFAs) after a high-fat meal.
   Methods: Oral glucose tolerance testing was used to assess insulin secretion, sensitivity, and disposition index (DI). Endothelial function, triglycerides, FFA, c-reactive protein, interleukin 6 (IL6), and adiponectin were measured both pre- and 3 hr postprandially (McDonald's Big Breakfast (R) and 12 ounce Sprite (R)) in obese adolescents (10-13 years, 9 black and 7 white). Endothelial function was assessed using reactive hyperemic changes in forearm vascular resistance (FVR).
   Results: Oral glucose tolerance test (OGTT) showed no difference in insulin sensitivity, but blacks tended to have (P = 0.08) higher insulin secretion and had increased DI (P = 0.003). After a high-fat meal, triglycerides increased in both groups (P < 0.001), tended to be lower in blacks compared with whites preprandially (64 +/- 33 mg/ dL vs 110 +/- 80, P = 0.064), and was lower postprandially (112 +/- 63 vs 188 +/- 112, P = 0.039). Pre- and postprandial FFA (Black: 0.58 +/- 0.15 and 0.39 +/- 0.18 vs. white: 0.44 +/- 0.14 and 0.26 +/- 0.06, P = 0.020) and adiponectin (P = 0.002) were increased in blacks. FFA decreased in both groups postprandially (P = 0.002). IL6 increased after the meal (P = 0.022). Endothelial function decreased postprandially (P < 0.02), but this was due to a decrease in preocclusion FVR.
   Conclusions: These results indicate that differences in fat metabolism are present in both black and white obese adolescents. How these differences explain higher rates of cardiometabolic disease in blacks is unclear.
C1 [Cazeau, Rachel-Marie; Rauch, Lindsey; Hoffman, Robert P.] Nationwide Childrens Hosp, Sect Endocrinol Metab & Diabet, Columbus, OH USA.
   [Cazeau, Rachel-Marie; Rauch, Lindsey; Hoffman, Robert P.] Ohio State Univ, Dept Pediat, Clin Res Ctr, Div Pediat Endocrinol Metab & Diabet,Coll Med & P, Columbus, OH 43210 USA.
   [Huang, Hong; Bauer, John A.] Univ Kentucky, Dept Pediat, Lexington, KY USA.
   [Hoffman, Robert P.] Nationwide Childrens Hosp, Res Inst, Columbus, OH USA.
C3 University System of Ohio; Ohio State University; Nationwide Childrens
   Hospital; University System of Ohio; Ohio State University; University
   of Kentucky; University System of Ohio; Ohio State University;
   Nationwide Childrens Hospital; Research Institute at Nationwide
   Children's Hospital
RP Hoffman, RP (corresponding author), Nationwide Childrens Hosp, Div Pediat Endocrinol Metab & Diabet, 700 Childrens Dr, Columbus, OH 43205 USA.
EM rcazeaumd@gmail.com
RI Hoffman, Robert/E-3252-2011
OI Hoffman, Robert/0000-0003-3614-7381
FU Intramural Grant from the Research Institute at Nationwide Children's
   Hospital; Clinical Research Center at The Ohio State University from the
   National Center of Research Resources of the NIH [UL1-RR05755]
FX The authors would like to thank the staff at the Clinical Research
   Center at The Ohio State University for their assistance. This study was
   funded with an Intramural Grant from the Research Institute at
   Nationwide Children's Hospital. This study was supported by the Clinical
   Research Center at The Ohio State University, grant UL1-RR05755 from the
   National Center of Research Resources of the NIH.
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NR 44
TC 0
Z9 0
U1 0
U2 1
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-4196
EI 1557-8518
J9 METAB SYNDR RELAT D
JI Metab. Syndr. Relat. Disord.
PY 2016
VL 14
IS 7
BP 340
EP 346
DI 10.1089/met.2015.0122
PG 7
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA DU5WD
UT WOS:000382283200003
PM 27419255
OA Green Published
DA 2025-06-11
ER

PT J
AU Ma, H
   Lin, HD
   Hu, Y
   Li, XM
   He, WY
   Jin, XJ
   Gao, J
   Zhao, NQ
   Song, BB
   Pan, BS
   Gao, X
AF Ma, Hui
   Lin, Huandong
   Hu, Yu
   Li, Xiaoming
   He, Wanyuan
   Jin, Xuejuan
   Gao, Jian
   Zhao, Naiqing
   Song, Binbin
   Pan, Boshen
   Gao, Xin
TI Serum ferritin levels are associated with carotid atherosclerosis in
   Chinese postmenopausal women: the Shanghai Changfeng Study
SO BRITISH JOURNAL OF NUTRITION
LA English
DT Article
DE Ferritin; Carotid intima-media thickness; Carotid plaques; Carotid
   atherosclerosis
ID CARDIOVASCULAR RISK-FACTORS; CORONARY-HEART-DISEASE; C-REACTIVE PROTEIN;
   BODY IRON STATUS; METABOLIC SYNDROME; INSULIN-RESISTANCE; OXIDATIVE
   STRESS; PREVENTION; DIFFERENCE; REDUCTION
AB Postmenopausal women are at increased risk of CVD: the increased serum ferritin level may be involved in the pathogenesis. The aim of the present study is to investigate the relationship of ferritin and carotid atherosclerosis in postmenopausal women. A total of 1178 postmenopausal women (mean age, 60.8 years) were enrolled from the Changfeng Study. A standard interview, anthropometric measurements and laboratory analyses were performed for each participant. Bilateral CIMT (carotid intima-media thickness) were measured using ultrasonography, and the presence of carotid plaques was assessed. Serum ferritin was measured using electrochemiluminescence immunoassay. The results showed that serum ferritin was 181.9 (SD 65.8) ng/ml in the postmenopausal women. Multivariate, linear, stepwise regression analysis demonstrated that age (standardised beta = 0.233, P < 0.001), alanine transaminase (standardised beta = 0.194, P < 0.001), log homeostasis model assessment index for insulin resistance (standardised beta = 0.181, P < 0.001), TAG (standardised beta = 0.083, P = 0.003), Hb (standardised beta = 0.080, P = 0.004) and PPG (2-h glucose levels following a 75-g oral glucose challenge) (standardised beta = 0.079, P = 0.004) were independently associated with serum ferritin. Compared with the ferritin level of subjects in the first quartile, that in the fourth quartile had greater CIMT, and higher prevalence of carotid plaque. After adjusting for conventional CVD risk factors, Hb, leucocytes, log urine albumin: creatinine ratio and liver function, the ferritin level of postmenopausal women in the fourth quartile had a 1.587-fold increased risk of carotid plaques relative to those in the lowest quartile. In conclusion, these results suggest that serum ferritin is independently and positively associated with carotid atherosclerosis in postmenopausal women and that ferritin may be implicated in atherosclerosis.
C1 [Ma, Hui; Hu, Yu] Fudan Univ, Zhongshan Hosp, Dept Geriatr, Shanghai 200032, Peoples R China.
   [Lin, Huandong; Li, Xiaoming; Gao, Xin] Fudan Univ, Zhongshan Hosp, Dept Endocrinol & Metab, Shanghai 200032, Peoples R China.
   [He, Wanyuan] Fudan Univ, Zhongshan Hosp, Dept Ultrasonog, Shanghai 200032, Peoples R China.
   [Jin, Xuejuan] Fudan Univ, Zhongshan Hosp, Clin Epidemiol Ctr, Shanghai 200032, Peoples R China.
   [Gao, Jian] Fudan Univ, Zhongshan Hosp, Dept Clin Nutr, Shanghai 200032, Peoples R China.
   [Zhao, Naiqing] Fudan Univ, Dept Biostat, Coll Publ Hlth, Shanghai 200032, Peoples R China.
   [Song, Binbin; Pan, Boshen] Fudan Univ, Zhongshan Hosp, Dept Lab Med, Shanghai 20032, Peoples R China.
C3 Fudan University; Fudan University; Fudan University; Fudan University;
   Fudan University; Fudan University; Fudan University
RP Gao, X (corresponding author), Fudan Univ, Zhongshan Hosp, Dept Endocrinol & Metab, Shanghai 200032, Peoples R China.
EM happy20061208@126.com; gao.xin@zs-hospital.sh.cn
RI ding, jianyong/KVZ-3622-2024; He, Wei/H-2113-2012
OI Gao, Xin/0000-0003-1864-7796
FU Changfeng Health Center; Health Bureau of Putuo District; Major State
   Basic Research Development Program of China [2012CB524906]; National
   Natural Science Foundation of China [81270933]; Shanghai Municipal
   Health Bureau Foundation [12GWZX0103, 2013ZYJB0802]
FX The Shanghai Changfeng Study has received great support from Changfeng
   Health Center, the Health Bureau of Putuo District, and the committees
   of all the sub-communities of Changfeng. The contributions of all the
   working staffs and participants of the study are greatly appreciated and
   acknowledged.This work was supported by grants made available to X. G.
   from the Major State Basic Research Development Program of China
   (2012CB524906 http://www.973.gov.cn/Default_3.aspx), National Natural
   Science Foundation of China (81270933), and Shanghai Municipal Health
   Bureau Foundation (12GWZX0103 and 2013ZYJB0802).
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NR 40
TC 13
Z9 16
U1 0
U2 9
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1145
EI 1475-2662
J9 BRIT J NUTR
JI Br. J. Nutr.
PD OCT 14
PY 2015
VL 114
IS 7
BP 1064
EP 1071
DI 10.1017/S0007114515001944
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA CS4AR
UT WOS:000362017700007
PM 26395322
OA Bronze
DA 2025-06-11
ER

PT J
AU Xie, CQ
   Hu, J
   Motloch, LJ
   Karam, BS
   Akar, FG
AF Xie, Chaoqin
   Hu, Jun
   Motloch, Lukas J.
   Karam, Basil S.
   Akar, Fadi G.
TI The Classically Cardioprotective Agent Diazoxide Elicits Arrhythmias in
   Type 2 Diabetes Mellitus
SO JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
LA English
DT Article
DE action potentials; ischemia; mitochondria; obesity; repolarization;
   ventricular tachycardia
ID K-ATP CHANNELS; MEDIATED INSULIN SUPPRESSION;
   AMERICAN-HEART-ASSOCIATION; ACTIVATED PROTEIN-KINASE; OXIDATIVE STRESS;
   PERMEABILITY TRANSITION; MYOCARDIAL-INFARCTION; METABOLIC SYNDROME;
   OBESE MEN; MITOCHONDRIAL
AB BACKGROUND Type 2 diabetes mellitus (T2DM) is associated with an enhanced propensity for ventricular tachyarrhythmias (VTs) under conditions of metabolic demand. Activation of mitochondrial adenosine triphosphate-sensitive potassium (K-ATP) channels by low-dose diazoxide (DZX) improves hypoglycemia-related complications, metabolic function, and triglyceride and free fatty acid levels and reverses weight gain in T2DM.
   OBJECTIVES In this study, we hypothesized that DZX prevents ischemia-mediated arrhythmias in T2DM via its putative cardioprotective and antidiabetic property.
   METHODS Zucker obese diabetic fatty (ZO) rats (n = 43) with T2DM were studied. Controls consisted of Zucker lean (ZL; n = 13) and normal Sprague-Dawley (SprD; n = 30) rats. High-resolution optical action potential mapping was performed before and during challenge with no-flow ischemia for 12 min.
   RESULTS Electrophysiological properties were relatively stable in T2DM hearts at baseline. In contrast, ischemia uncovered major differences between groups, because action potential duration (APD) in T2DM failed to undergo progressive adaptation to ischemic challenge. DZX promoted the incidence of arrhythmias, because all DZX-treated T2DM hearts exhibited ischemia-induced VTs that persisted on reperfusion. In contrast, untreated T2DM and controls did not exhibit VT during ischemia. Unlike DZX, pinacidil promoted ischemia-mediated arrhythmias in both control and T2DM hearts. Rapid and spatially heterogeneous shortening of APD preceded the onset of arrhythmias in T2DM. DZX-mediated proarrhythmia in T2DM was not related to changes in the messenger ribonucleic acid expression of Kir6.1, Kir6.2, SUR1A, SUR1B, SUR2A, SUR2B, or ROMK (renal outer medullary potassium channel).
   CONCLUSIONS Ischemia uncovers a paradoxical resistance of T2DM hearts to APD adaptation. DZX reverses this property, resulting in rapid and heterogeneous APD shortening. This promotes reentrant VT during ischemia. DZX should be avoided in diabetic patients at risk of ischemic events. (C) 2015 by the American College of Cardiology Foundation.
C1 [Xie, Chaoqin; Hu, Jun; Motloch, Lukas J.; Karam, Basil S.; Akar, Fadi G.] Icahn Sch Med Mt Sinai, Cardiac Bioelect Res Lab, Cardiovasc Inst, New York, NY 10029 USA.
C3 Icahn School of Medicine at Mount Sinai
RP Akar, FG (corresponding author), Icahn Sch Med Mt Sinai, Cardiovasc Res Ctr, One Gustave L Levy Pl,Box 1030, New York, NY 10029 USA.
EM fadi.akar@mssm.edu
OI Motloch, Lukas Jaroslaw/0000-0002-5829-6743; Akar, Fadi
   G./0000-0001-9146-8407
FU NHLBI NIH HHS [R21 HL097108, R01 HL119046, R21 HL114378] Funding Source:
   Medline
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NR 37
TC 17
Z9 18
U1 0
U2 4
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0735-1097
EI 1558-3597
J9 J AM COLL CARDIOL
JI J. Am. Coll. Cardiol.
PD SEP 8
PY 2015
VL 66
IS 10
BP 1144
EP 1156
DI 10.1016/j.jacc.2015.06.1329
PG 13
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA CQ1OR
UT WOS:000360367600009
PM 26337994
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Li, XL
   Li, J
   Lu, XL
   Ma, HH
   Shi, HT
   Li, H
   Xie, DH
   Dong, L
   Liang, CL
AF Li, Xiuli
   Li, Jin
   Lu, Xiaolan
   Ma, Huihui
   Shi, Haitao
   Li, Hong
   Xie, Danhong
   Dong, Lei
   Liang, Chunlian
TI Treatment with PPARδ agonist alleviates non-alcoholic fatty liver
   disease by modulating glucose and fatty acid metabolic enzymes in a rat
   model
SO INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
LA English
DT Article
DE non-alcoholic fatty liver disease; peroxisome proliferator-activated
   receptor delta; GW501516; insulin resistance enzymes related to lipid
   metabolism
ID PROLIFERATOR-ACTIVATED RECEPTORS; ENDOPLASMIC-RETICULUM STRESS;
   INSULIN-RESISTANCE; LIPID-METABOLISM; GENE-EXPRESSION; BETA-OXIDATION;
   ALPHA; STEATOHEPATITIS; MICE; ADIPOGENESIS
AB Non-alcoholic fatty liver disease (NAFLD) is an increasingly common condition which is associated with certain features of metabolic syndrome and insulin resistance. Peroxisome proliferator-activated receptor (PPAR)delta is an important regulator of energy metabolism and insulin resistance in diabetes. However, the function of PPARd in NAFLD has not yet been fully elucidated. In the present study, in order to explore the function of PPAR delta in NAFLD, we created a rat model of NALFD induced by a high-fat diet (HFD) and treated the rats with GW501516, a PPAR delta agonist. We found that the lipid levels decreased, and hepatocellular ballooning and inflammatory cell infiltration were also significantly decreased following treatment of the rats with GW501516 compared to the untreated rats. Treatment with GW501516 also significantly decreased the homeostasis model assessment of insulin resistance (HOMA-IR) index, as well as the low-density lipoprotein (LDL) levels. In addition, treatment with GW501516 increased the levels of insulin-like growth factor-1 (IGF-1) and high-density lipoprotein (HDL) compared to the HFD group. Furthermore, the elevated levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma-glutamyl transpeptidase (GGT) and alkaline phosphatase (ALP) in the HFD group were all restored to the normal control levels following treatment with GW501516. RT-qPCR and immunohistochemical staining revealed that the expression levels of sterol regulatory element binding protein-1c (SREBP-1c) and glucose transporter 2 (GLUT-2) were both restored to normal control levels following treatment with GW501516. Also, the levels of enzymes related to lipid metabolism were increased following treatment with GW501516. In conclusion, our findings demonstrate that treatment with GW501516 alleviates NAFLD by modulating glucose and fatty acid metabolism.
C1 [Li, Xiuli; Liang, Chunlian] Xi An Jiao Tong Univ, Sch Med, Affiliated Hosp 2, Dept Geriatr, Xian 710004, Shaanxi, Peoples R China.
   [Li, Jin; Lu, Xiaolan; Ma, Huihui; Shi, Haitao; Li, Hong; Xie, Danhong; Dong, Lei] Xi An Jiao Tong Univ, Sch Med, Affiliated Hosp 2, Dept Gastroenterol, Xian 710004, Shaanxi, Peoples R China.
   [Li, Jin] Xi An Jiao Tong Univ, Sch Med, Xian Cent Hosp, Dept Gastroenterol, Xian 710004, Shaanxi, Peoples R China.
C3 Xi'an Jiaotong University; Xi'an Jiaotong University; Xi'an Jiaotong
   University
RP Lu, XL (corresponding author), Xi An Jiao Tong Univ, Sch Med, Affiliated Hosp 2, Dept Gastroenterol, 157 West 5th Rd, Xian 710004, Shaanxi, Peoples R China.
EM xiaolanlus@163.com
RI ma, huihui/HDM-4386-2022; , Haitao/HSG-8989-2023
OI , Haitao/0000-0003-2354-5209
FU National Natural Science Foundation of China [81070328]
FX The present study was supported by a grant from the National Natural
   Science Foundation of China (no. 81070328).
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NR 52
TC 15
Z9 22
U1 2
U2 16
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1107-3756
EI 1791-244X
J9 INT J MOL MED
JI Int. J. Mol. Med.
PD SEP
PY 2015
VL 36
IS 3
BP 767
EP 775
DI 10.3892/ijmm.2015.2270
PG 9
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA CR2DH
UT WOS:000361134700019
PM 26133486
OA Bronze
DA 2025-06-11
ER

PT J
AU Rouse, M
   Younès, A
   Egan, JM
AF Rouse, Michael
   Younes, Antoine
   Egan, Josephine M.
TI Resveratrol and curcumin enhance pancreatic β-cell function by
   inhibiting phosphodiesterase activity
SO JOURNAL OF ENDOCRINOLOGY
LA English
DT Article
DE type 2 diabetes; resveratrol; curcumin; phosphodiesterase; beta-cell
ID INSULIN-RESISTANCE; GLUCOSE-INTOLERANCE; METABOLIC SYNDROME; OXIDATIVE
   STRESS; MICE; CAMP; DIET; SUPPLEMENTATION; DYSFUNCTION; ANTIOXIDANT
AB Resveratrol (RES) and curcumin (CUR) are polyphenols that are found in fruits and turmeric, and possess medicinal properties that are beneficial in various diseases, such as heart disease, cancer, and type 2 diabetes mellitus (T2DM). Results from recent studies have indicated that their therapeutic properties can be attributed to their anti-inflammatory effects. Owing to reports stating that they protect against beta-cell dysfunction, we studied their mechanism(s) of action in beta-cells. In T2DM, cAMP plays a critical role in glucose- and incretin-stimulated insulin secretion as well as overall pancreatic beta-cell health. A potential therapeutic target in the management of T2DM lies in regulating the activity of phosphodiesterases (PDEs), which degrade cAMP. Both RES and CUR have been reported to act as PDE inhibitors in various cell types, but it remains unknown if they do so in pancreatic beta-cells. In our current study, we found that both RES (0.1-10 mu mol/l) and CUR (1-100 pmol/l)-regulated insulin secretion under glucose- stimulated conditions. Additionally, treating beta-cell lines and human islets with these polyphenols led to increased intracellular cAMP levels in a manner similar to 3-isobutyl-1-methylxanthine, a classic PDE inhibitor. When we investigated the effects of RES and CUR on PDEs, we found that treatment significantly downregulated the mRNA expression of most of the 11 PDE isozymes, including PDE3B, PDE8A, and PDE10A, which have been linked previously to regulation of insulin secretion in islets. Furthermore, RES and CUR inhibited PDE activity in a dose-dependent manner in beta-cell lines and human islets. Collectively, we demonstrate a novel role for natural-occurring polyphenols as PDE inhibitors that enhance pancreatic beta-cell function.
C1 [Rouse, Michael; Egan, Josephine M.] NIA, Clin Invest Lab, Intramural Res Program, NIH, Baltimore, MD 21224 USA.
   [Younes, Antoine] NIA, Lab Cardiovasc Sci, Intramural Res Program, NIH, Baltimore, MD 21224 USA.
C3 National Institutes of Health (NIH) - USA; NIH National Institute on
   Aging (NIA); National Institutes of Health (NIH) - USA; NIH National
   Institute on Aging (NIA)
RP Egan, JM (corresponding author), NIA, Clin Invest Lab, Intramural Res Program, NIH, 251 Bayview Blvd, Baltimore, MD 21224 USA.
EM eganj@grc.nia.nih.gov
FU Intramural Research Program of the National Institute on Aging
FX This work was supported by the Intramural Research Program of the
   National Institute on Aging.
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NR 54
TC 97
Z9 102
U1 5
U2 35
PU BIOSCIENTIFICA LTD
PI BRISTOL
PA EURO HOUSE, 22 APEX COURT WOODLANDS, BRADLEY STOKE, BRISTOL BS32 4JT,
   ENGLAND
SN 0022-0795
EI 1479-6805
J9 J ENDOCRINOL
JI J. Endocrinol.
PD NOV
PY 2014
VL 223
IS 2
BP 107
EP 117
DI 10.1530/JOE-14-0335
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA AR5YT
UT WOS:000343659000005
PM 25297556
OA Green Submitted, Green Accepted, hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Shen, Y
   Lu, L
   Ding, FH
   Sun, Z
   Zhang, RY
   Zhang, Q
   Yang, ZK
   Hu, J
   Chen, QJ
   Shen, WF
AF Shen, Ying
   Lu, Lin
   Ding, Feng Hua
   Sun, Zhen
   Zhang, Rui Yan
   Zhang, Qi
   Yang, Zheng Kun
   Hu, Jian
   Chen, Qiu Jing
   Shen, Wei Feng
TI Association of increased serum glycated albumin levels with low coronary
   collateralization in type 2 diabetic patients with stable angina and
   chronic total occlusion
SO CARDIOVASCULAR DIABETOLOGY
LA English
DT Article
DE Glycated albumin; Coronary collateralization; Diabetes
ID ENDOTHELIAL PROGENITOR CELLS; C-REACTIVE PROTEIN; ARTERY-DISEASE;
   END-PRODUCTS; OXIDATIVE STRESS; CIRCULATION; ANGIOGENESIS; ANGIOPLASTY;
   MANAGEMENT; MORTALITY
AB Background: We investigated whether serum glycated albumin (GA) levels are related to coronary collateralization in type 2 diabetic patients with chronic total occlusion.
   Methods: Blood levels of GA and glycosylated hemoglobin (HbA1c) were determined in 317 diabetic and 117 non-diabetic patients with stable angina and angiographic total occlusion of at least one major coronary artery. The degree of collaterals supplying the distal aspect of a total occlusion from the contra-lateral vessel was graded as low (Rentrop score of 0 or 1) or high collateralization (Rentrop score of 2 or 3).
   Results: For diabetic patients, GA (21.2 +/- 6.5% vs. 18.7 +/- 5.6%, P < 0.001) but not HbA1c levels (7.0 +/- 1.1% vs. 6.8 +/- 1.3%, P = 0.27) was significantly elevated in low collateralization than in high collateralization group, and correlated inversely with Rentrop score (Spearmen's r = -0.28, P < 0.001; Spearmen's r = -0.10, P = 0.09, respectively). There was a trend towards a larger area under the curve of GA compared with that of HbA1c for detecting the presence of low collateralization (0.64 vs. 0.58, P = 0.15). In non-diabetic patients, both GA and HbA1c levels did not significantly differ regardless the status of coronary collateralization. In multivariable analysis, female gender, age > 65 years, smoke, non-hypertension, duration of diabetes > 10 years, metabolic syndrome, eGFR < 90 ml/min/1.73 m(2), and GA > 18.3% were independently determinants for low collateralization in diabetic patients.
   Conclusions: Increased GA levels in serum are associated with impaired collateral growth in type 2 diabetic patients with stable angina and chronic total occlusion.
C1 [Shen, Ying; Lu, Lin; Ding, Feng Hua; Sun, Zhen; Zhang, Rui Yan; Zhang, Qi; Yang, Zheng Kun; Hu, Jian; Shen, Wei Feng] Shanghai Jiao Tong Univ, Sch Med, Shanghai Rui Jin Hosp, Dept Cardiol, Shanghai 200025, Peoples R China.
   [Lu, Lin; Chen, Qiu Jing; Shen, Wei Feng] Shanghai Jiao Tong Univ, Inst Cardiovasc Dis, Sch Med, Shanghai 200025, Peoples R China.
C3 Shanghai Jiao Tong University; Shanghai Jiao Tong University
RP Shen, WF (corresponding author), Shanghai Jiao Tong Univ, Sch Med, Shanghai Rui Jin Hosp, Dept Cardiol, Shanghai 200025, Peoples R China.
EM rjshenweifeng@gmail.com
RI yang, zheng/HGC-7753-2022; Zhang, Ruiyan/HHC-5329-2022; Shen,
   Weifeng/AAE-2493-2022
FU National Natural Science Foundation of China [81070240, 81070178];
   Science Technology Committee of Shanghai Municipal Government
   [10JC1410500, 2011019]
FX This study was supported by the National Natural Science Foundation of
   China (81070240 and 81070178) and Science Technology Committee of
   Shanghai Municipal Government (10JC1410500 and 2011019).
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NR 41
TC 37
Z9 38
U1 1
U2 14
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1475-2840
J9 CARDIOVASC DIABETOL
JI Cardiovasc. Diabetol.
PD NOV 8
PY 2013
VL 12
AR 165
DI 10.1186/1475-2840-12-165
PG 7
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism
GA 291BV
UT WOS:000329803500001
PM 24209601
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Rogge, BP
   Cramariuc, D
   Lonnebakken, MT
   Gohlke-Bärwolf, C
   Chambers, JB
   Boman, K
   Gerdts, E
AF Rogge, Barbara P.
   Cramariuc, Dana
   Lonnebakken, Mai Tone
   Gohlke-Baerwolf, Christa
   Chambers, John B.
   Boman, Kurt
   Gerdts, Eva
TI Effect of Overweight and Obesity on Cardiovascular Events in
   Asymptomatic Aortic Stenosis
SO JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
LA English
DT Article
DE aortic valve stenosis; body mass index; cardiovascular disease; obesity;
   outcomes
ID LEFT-VENTRICULAR HYPERTROPHY; BODY-MASS INDEX; METABOLIC SYNDROME;
   SYSTOLIC FUNCTION; DISEASE PROGRESSION; AMERICAN-INDIANS; VALVE
   STENOSIS; MORTALITY; GEOMETRY; IMPACT
AB Objectives This study investigated whether overweight and obesity impacted outcome in patients with aortic valve stenosis (AS).
   Background Increased body mass index (BMI) is a strong predictor of higher cardiovascular (CV) morbidity and mortality in the general population but not among patients undergoing heart surgery.
   Methods Cardiovascular events in 1,664 patients with initially asymptomatic AS were recorded during a mean of 4.3 years of follow-up in the SEAS (Simvastatin Ezetimibe in Aortic Stenosis) study. Patients were grouped according to baseline BMI class.
   Results Overweight (n = 737) and obese patients (n = 334) had higher prevalence of hypertension, more abnormal left ventricular geometry, and lower stress-corrected midwall shortening throughout the study compared with normal weight patients (all p < 0.01). The AS progression rate did not differ between BMI classes. In univariate Cox regression, overweight was associated with a 17% to 22% lower rate of AS-related (p = 0.04) and ischemic CV events (p = 0.05). In multivariate analyses, adjusting for AS severity and differences in baseline characteristics, overweight had no significant influence on the rate of ischemic CV or AS-related events, whereas overweight and obesity had 46% and 67% higher rate of total mortality and 42% and 69% higher rate of combined hospital stay for heart failure and death from any cause, respectively, compared with normal weight patients (all p < 0.05).
   Conclusions In patients with initially asymptomatic AS participating in the SEAS study, overweight and obesity did not influence AS progression or rate of AS-related or ischemic CV events but were both associated with increased mortality. (C) 2013 by the American College of Cardiology Foundation
C1 [Rogge, Barbara P.; Cramariuc, Dana; Lonnebakken, Mai Tone; Gerdts, Eva] Haukeland Hosp, Dept Heart Dis, N-5021 Bergen, Norway.
   [Lonnebakken, Mai Tone; Gerdts, Eva] Univ Bergen, Dept Clin Sci, Bergen, Norway.
   [Gohlke-Baerwolf, Christa] Herz Zentrum Bad Krozingen, Bad Krozingen, Germany.
   [Chambers, John B.] Guys & St Thomas Hosp, London SE1 9RT, England.
   [Boman, Kurt] Umea Univ, Inst Publ Hlth & Clin Med, Dept Med, Skelleftea, Sweden.
C3 University of Bergen; Haukeland University Hospital; University of
   Bergen; Guy's & St Thomas' NHS Foundation Trust; Umea University
RP Rogge, BP (corresponding author), Haukeland Hosp, Dept Heart Dis, N-5021 Bergen, Norway.
EM barbara_lund@yahoo.no
RI Chambers, John/LKL-6655-2024; Lonnebakken, Mai/AAL-2328-2021; Cramariuc,
   Dana/P-2086-2019
OI Boman, Kurt/0000-0002-0350-2132; Lonnebakken, Mai
   Tone/0000-0002-5600-8859; Cramariuc, Dana/0000-0002-1593-2017
FU Merck Schering Plough Singapore Company, LLC, Singapore
FX The SEAS study was supported by Merck Schering Plough Singapore Company,
   LLC, Singapore. Dr. Boman has received honoraria from Merck Schering
   Plough and was on the steering commitee of SEAS. All other authors have
   reported that they have no relationships relevant to the contents of
   this paper to disclose.
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NR 39
TC 47
Z9 48
U1 0
U2 4
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0735-1097
EI 1558-3597
J9 J AM COLL CARDIOL
JI J. Am. Coll. Cardiol.
PD OCT 29
PY 2013
VL 62
IS 18
BP 1683
EP 1690
DI 10.1016/j.jacc.2013.04.081
PG 8
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 242JU
UT WOS:000326237300008
PM 23770175
OA Bronze
DA 2025-06-11
ER

PT J
AU Monsénégo, J
   Mansouri, A
   Akkaoui, M
   Lenoir, V
   Esnous, C
   Fauveau, V
   Tavernier, V
   Girard, J
   Prip-Buus, C
AF Monsenego, Julia
   Mansouri, Abdelhak
   Akkaoui, Marie
   Lenoir, Veronique
   Esnous, Catherine
   Fauveau, Veronique
   Tavernier, Valentin
   Girard, Jean
   Prip-Buus, Carina
TI Enhancing liver mitochondrial fatty acid oxidation capacity in obese
   mice improves insulin sensitivity independently of hepatic steatosis
SO JOURNAL OF HEPATOLOGY
LA English
DT Article
DE Carnitine palmitoyltransferase 1; Mitochondria; Fatty liver; Obesity;
   Insulin resistance; Lipotoxicity
ID MALONYL-COA; ACYLTRANSFERASE 1; RESISTANCE; METABOLISM; EXPRESSION;
   OVEREXPRESSION; INHIBITION; SUFFICIENT; MODULATION; PROTECT
AB Background & Aims: Despite major public health concern, therapy for non-alcoholic fatty liver, the liver manifestation of the metabolic syndrome often associated with insulin resistance (IR), remains elusive. Strategies aiming to decrease liver lipogenesis effectively corrected hepatic steatosis and IR in obese animals. However, they also indirectly increased mitochondrial long-chain fatty acid oxidation (mFAO) by decreasing malonyl-CoA, a lipogenic intermediate, which is the allosteric inhibitor of carnitine palmitoyltransferase 1 (CPT1A), the key enzyme of mFAO. We thus addressed whether enhancing hepatic mFAO capacity, through a direct modulation of liver CPT1A/malonyl-CoA partnership, can reverse an already established hepatic steatosis and IR in obese mice.
   Methods: Adenovirus-mediated liver expression of a malonyl-CoA-insensitive CPT1A (CPT1mt) in high-fat/high-sucrose (HF/HS) diet-induced or genetically (ob/ob) obese mice was followed by metabolic and physiological investigations.
   Results: In association with increased hepatic mFAO capacity, liver CPT1mt expression improved glucose tolerance and insulin response to a glucose load in HF/HS and ob/ob mice, showing increased insulin sensitivity, and corrected IR in ob/ob mice. Surprisingly, hepatic steatosis was not affected in CPT1mt-expressing obese mice, indicating a clear dissociation between hepaticsteatosis and IR. Moreover, liver CPT1mt expression rescued HF/HS-induced impaired hepatic insulin signaling at the level of IRS-1, IRS-2, Akt, and GSK-3 beta, most likely through the observed decrease in the HF/HS-induced accumulation of lipotoxic lipids, oxidative stress, and JNK activation.
   Conclusions: Enhancing hepatic mFAO capacity is sufficient to reverse a state of IR and glucose intolerance in obese mice independently of hepatic steatosis. (C) 2011 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
C1 [Prip-Buus, Carina] Inst Cochin, Dept Endocrinol Metab & Canc, INSERM, U1016, F-75014 Paris, France.
   CNRS, UMR8104, Paris, France.
   Univ Paris 05, Paris, France.
C3 Institut National de la Sante et de la Recherche Medicale (Inserm);
   Universite Paris Cite; Universite Paris Cite; Centre National de la
   Recherche Scientifique (CNRS); CNRS - National Institute for Biology
   (INSB); Universite Paris Cite
RP Prip-Buus, C (corresponding author), Inst Cochin, Dept Endocrinol Metab & Canc, INSERM, U1016, 24 Rue Faubourg St Jacques, F-75014 Paris, France.
EM carina.prip-buus@inserm.fr
RI PRIP-BUUS, Carina/P-9084-2017; Mansouri, Abdelhak/D-9100-2013
OI Mansouri, Abdelhak/0000-0003-4471-7276; Prip-Buus,
   Carina/0000-0002-2153-7857
FU Ministere de la Recherche [0220527]; ALFEDIAM-AstraZeneca; INSERM
   [ASE04179KSA]; Agence Nationale de la Recherche "Cardio-vasculaire,
   Obesite, Diabete" [APV05051KSA]; University of Paris VI; Ministere de
   l'Education Nationale, de la Recherche et de la Technologie; ALFEDIAM;
   AFM (Association Francaise contre les Myopathies)
FX This study was supported by grants from the Ministere de la Recherche
   "ACI Biologie du Developpement et Physiologie Integrative" (Grant No.
   0220527), ALFEDIAM-AstraZeneca, INSERM "Programme National de Recherches
   sur le Diabete" (Grant No. ASE04179KSA) and the Agence Nationale de la
   Recherche "Cardio-vasculaire, Obesite, Diabete" (Grant No. APV05051KSA).
   J.M. and M.A. were respectively supported by a graduate fellowship from
   the University of Paris VI and the Ministere de l'Education Nationale,
   de la Recherche et de la Technologie, and A.M. by a Postdoctoral Award
   from ALFEDIAM. We thank Pr. Wolfgang Langhans (Institute of Food,
   Nutrition and Health, ETH Zurich, Switzerland), Dr. France Demaugre
   (INSERM U1018, Villejuif, France) and Dr. Anne Lombes (INSERM U1016,
   Paris, France) for critical review of the manuscript. We thank the
   Transgenesis Core and Animal Facilities of the Cochin Institute, the
   Vector Core of the University Hospital of Nantes supported by the AFM
   (Association Francaise contre les Myopathies) for providing the
   adenovirus vectors, and Justine Bertrand-Michel (Lipidomic Core, IFR
   150, Toulouse, France) for lipidomic analysis.
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NR 38
TC 74
Z9 79
U1 0
U2 20
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0168-8278
EI 1600-0641
J9 J HEPATOL
JI J. Hepatol.
PD MAR
PY 2012
VL 56
IS 3
BP 632
EP 639
DI 10.1016/j.jhep.2011.10.008
PG 8
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 904TQ
UT WOS:000301221200020
PM 22037024
DA 2025-06-11
ER

PT J
AU Bonnet, F
   Ducluzeau, PH
   Gastaldelli, A
   Laville, M
   Anderwald, CH
   Konrad, T
   Mari, A
   Balkan, B
AF Bonnet, Fabrice
   Ducluzeau, Pierre-Henri
   Gastaldelli, Amalia
   Laville, Martine
   Anderwald, Christian H.
   Konrad, Thomas
   Mari, Andrea
   Balkan, Beverley
CA RISC Study Grp
TI Liver Enzymes Are Associated With Hepatic Insulin Resistance, Insulin
   Secretion, and Glucagon Concentration in Healthy Men and Women
SO DIABETES
LA English
DT Article
ID GAMMA-GLUTAMYL-TRANSFERASE; MIDDLE-AGED MEN; ALANINE AMINOTRANSFERASE;
   METABOLIC SYNDROME; GLUCOSE-TOLERANCE; OXIDATIVE STRESS; DOSE-RESPONSE;
   RISK; SENSITIVITY; HUMANS
AB OBJECTIVE-The pathophysiological mechanisms to explain the association between risk of type 2 diabetes and elevated concentrations of -gamma-glutamyltransferase (GGT) and alanineamino-transferase (ALT) remain poorly characterized. We explored the association of liver enzymes with peripheral and hepatic insulin resistance, insulin secretion, insulin clearance, and glucagon concentration.
   RESEARCH DESIGN AND METHODS-We studied 1,309 nondiabetic individuals from the Relationship between Insulin Sensitivity and Cardiovascular disease (RISC) study; all had a euglycemic-hyperinsulinemic clamp and an oral glucose tolerance test (OGTT) with assessment of insulin secretion and hepatic insulin extraction. The hepatic insulin resistance index was calculated in 393 individuals.
   RESULTS-In both men and women, plasma concentrations of GGT and ALT were inversely related with insulin sensitivity (Mu) (all P < 0.01). Likewise, the hepatic insulin resistance index was positively correlated with both GGT (r = 0.37, P < 0.0001, men; r = 0.36, P < 0.0001, women) and ALT (r = 0.25, P = 0.0005, men; r = 0.18, P = 0.01, women). These associations persisted in multivariable models. Increased GGT and ALT were significantly associated with higher insulin secretion rates and with both reduced endogenous clearance of insulin and hepatic insulin extraction during the OGTT (P = 0.0005 in men; P = 0.003 in women). Plasma fasting glucagon levels increased over ALT quartiles (men, quartile 4 vs. quartile 111.2 +/- 5.1 vs. 9.3 +/- 3.8 pmol/L, respectively, P = 0.0002; women, 9.0 +/- 4.3 vs. 7.6 +/- 3.1, P = 0.001).
   CONCLUSIONS-In healthy individuals, increased GGT and ALT were biomarkers of both systemic and hepatic insulin resistance with concomitant increased insulin secretion and decreased hepatic insulin clearance. The novel finding of a positive correlation between ALT and fasting glucagon level concentrations warrants confirmation in type 2 diabetes. Diabetes 60:1660-1667, 2011
C1 [Bonnet, Fabrice] Univ Rennes 1, Ctr Hosp Univ CHU Rennes, Serv Endocrinol Diabetol, INSERM,UMR 991, Rennes, France.
   [Ducluzeau, Pierre-Henri] CHU Angers, Serv Endocrinol Diabetol, Angers, France.
   [Gastaldelli, Amalia] Natl Res Ctr CNR, Inst Clin Physiol, Cardiometab Risk Unit, Pisa, Italy.
   [Laville, Martine] Ctr Rech Nutr Humaine, CRNH Rhone Alpes, INSERM, INRA,U 870 1235, Lyon, France.
   [Anderwald, Christian H.] Med Univ Vienna, Dept Internal Med 3, Clin Div Endocrinol & Metab, Vienna, Austria.
   [Konrad, Thomas] Goethe Univ Frankfurt, Acad Teaching Inst, Med Fac Johann Wolfgang Goethe, Inst Metab Res, Frankfurt, Germany.
   [Mari, Andrea] Inst Biomed Engn, Padua, Italy.
   [Balkan, Beverley] Ctr Rech Epidemiol & Sante Populat CESP, INSERM, U1018, Villejuif, France.
   [Balkan, Beverley] Univ Paris 11, UMRS 1018, Villejuif, France.
C3 Institut National de la Sante et de la Recherche Medicale (Inserm); CHU
   Rennes; Universite de Rennes; Universite d'Angers; Centre Hospitalier
   Universitaire d'Angers; Consiglio Nazionale delle Ricerche (CNR);
   Istituto di Fisiologia Clinica (IFC-CNR); Institut National de la Sante
   et de la Recherche Medicale (Inserm); INRAE; Medical University of
   Vienna; Goethe University Frankfurt; Institut National de la Sante et de
   la Recherche Medicale (Inserm); Universite Paris Saclay; Universite
   Paris Saclay; Institut National de la Sante et de la Recherche Medicale
   (Inserm)
RP Bonnet, F (corresponding author), Univ Rennes 1, Ctr Hosp Univ CHU Rennes, Serv Endocrinol Diabetol, INSERM,UMR 991, Rennes, France.
EM fabrice.bonnet@chu-rennes.fr
RI Bonnet, Fabrice/G-4255-2017; ducluzeau, pierre-henri/ABE-1092-2021;
   Mari, Andrea/N-7656-2019; Anderwald, Christian Heinz/AAG-2271-2021;
   Astiarraga, Brenno/T-2100-2017; Gastaldelli, Amalia/H-3319-2014
OI Anderwald, Christian Heinz/0000-0001-7485-0815; Krebs,
   Michael/0000-0002-9265-7274; Roden, Michael/0000-0001-8200-6382; Lalic,
   Nebojsa/0000-0002-8082-6560; Astiarraga, Brenno/0000-0003-2216-8974;
   Gastaldelli, Amalia/0000-0003-2594-1651; Boorsma,
   Wiebe/0009-0004-8619-6661; Carraro, Raffaele/0000-0002-5874-8076;
   Hatunic, Mensud/0000-0002-9693-1226; Lalic,
   Katarina/0000-0002-8070-1899; Melander, Olle/0000-0002-2581-484X;
   Muscelli, Elza/0000-0001-6979-3553
FU European Union [QLG1-CT-2001-01252]; Merck Serono, France
FX The RISC study was partly supported by European Union grant
   QLG1-CT-2001-01252. The European Group for the Study of Insulin
   Resistance (EGIR) group activities are supported by an unrestricted
   research grant from Merck Serono, France.
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NR 35
TC 113
Z9 125
U1 0
U2 9
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0012-1797
J9 DIABETES
JI Diabetes
PD JUN
PY 2011
VL 60
IS 6
BP 1660
EP 1667
DI 10.2337/db10-1806
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 774FE
UT WOS:000291369600003
PM 21521874
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Tweedie, C
   Romestaing, C
   Burelle, Y
   Safdar, A
   Tarnopolsky, MA
   Seadon, S
   Britton, SL
   Koch, LG
   Hepple, RT
AF Tweedie, Constance
   Romestaing, Caroline
   Burelle, Yan
   Safdar, Adeel
   Tarnopolsky, Mark A.
   Seadon, Scott
   Britton, Steven L.
   Koch, Lauren G.
   Hepple, Russell T.
TI Lower oxidative DNA damage despite greater ROS production in muscles
   from rats selectively bred for high running capacity
SO AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE
   PHYSIOLOGY
LA English
DT Article
DE adaptation; mitochondrial respiration; aging; oxidative metabolism;
   metabolic syndrome
ID FREE-RADICAL GENERATION; LOW AEROBIC CAPACITY; SKELETAL-MUSCLE;
   MITOCHONDRIAL DYSFUNCTION; ARTIFICIAL SELECTION; SUPEROXIDE DISMUTASES;
   CALORIC RESTRICTION; ENZYME-ACTIVITY; REPAIR ACTIVITY; FIBER-TYPE
AB Tweedie C, Romestaing C, Burelle Y, Safdar A, Tarnopolsky MA, Seadon S, Britton SL, Koch LG, Hepple RT. Lower oxidative DNA damage despite greater ROS production in muscles from rats selectively bred for high running capacity. Am J Physiol Regul Integr Comp Physiol 300: R544-R553, 2011. First published December 15, 2010; doi: 10.1152/ajpregu.00250.2010.-Artificial selection in rat has yielded high-capacity runners (HCR) and low-capacity runners (LCR) that differ in intrinsic (untrained) aerobic exercise ability and metabolic disease risk. To gain insight into how oxygen metabolism may have been affected by selection, we compared mitochondrial function, oxidative DNA damage (8-dihydroxy-guanosine; 8dOHG), and antioxidant enzyme activities in soleus muscle (Sol) and gastrocnemius muscle (Gas) of adult and aged LCR vs. HCR rats. In Sol of adult HCR rats, maximal ADP-stimulated respiration was 37% greater, whereas in Gas of adult HCR rats, there was a 23% greater complex IV-driven respiratory capacity and 54% greater leak as a fraction of electron transport capacity (suggesting looser mitochondrial coupling) vs. LCR rats. H2O2 emission per gram of muscle was 24-26% greater for both muscles in adult HCR rats vs. LCR, although H2O2 emission in Gas was 17% lower in HCR, after normalizing for citrate synthase activity (marker of mitochondrial content). Despite greater H2O2 emission, 8dOHG levels were 62-78% lower in HCR rats due to 62-96% higher superoxide dismutase activity in both muscles and 47% higher catalase activity in Sol muscle in adult HCR rats, with no evidence for higher 8 oxoguanine glycosylase (OGG1; DNA repair enzyme) protein expression. We conclude that genetic segregation for high running capacity has generated a molecular network of cellular adaptations, facilitating a superior response to oxidative stress.
C1 [Tweedie, Constance; Romestaing, Caroline; Seadon, Scott; Hepple, Russell T.] Univ Calgary, Muscle & Aging Lab, Fac Kinesiol, Calgary, AB, Canada.
   [Burelle, Yan] Univ Montreal, Dept Kinesiol, Montreal, PQ, Canada.
   [Safdar, Adeel; Tarnopolsky, Mark A.] McMaster Univ, Dept Pediat, Hamilton, ON, Canada.
   [Safdar, Adeel; Tarnopolsky, Mark A.] McMaster Univ, Dept Med, Hamilton, ON, Canada.
   [Britton, Steven L.; Koch, Lauren G.] Univ Michigan, Dept Anesthesiol, Ann Arbor, MI 48109 USA.
   [Hepple, Russell T.] Univ Calgary, Fac Med, Calgary, AB, Canada.
C3 University of Calgary; Universite de Montreal; McMaster University;
   McMaster University; University of Michigan System; University of
   Michigan; University of Calgary
RP Hepple, RT (corresponding author), Royal Victoria Hosp, Crit Care Div, 687 Pine Ave W, Montreal, PQ H3A 1A1, Canada.
EM hepple@ucalgary.ca
RI Burelle, Yan/AAF-8104-2021; Koch, Lauren/D-1258-2010; romestaing,
   caroline/O-8794-2017
OI Safdar, Adeel/0000-0003-2469-0467; Safdar, Adeel/0000-0002-7453-7770;
   Hepple, Russell/0000-0003-3640-486X; romestaing,
   caroline/0000-0002-6877-9626
FU Canadian Institutes of Health Research [MOP 57808, IAO 84673]; Natural
   Sciences and Engineering Research Council [RPG 238805]; National Center
   for Research Resources of the National Institutes of Health [R24
   RR017718]; Canadian Institutes of Health Research; Alberta Heritage
   Foundation for Medical Research; Fonds de Recherche en Sante du Quebec
FX This work was funded by operating grants from the Canadian Institutes of
   Health Research (MOP 57808 and IAO 84673 to R. T. Hepple, and BCA 20071
   to M. A. Tarnopolsky), Natural Sciences and Engineering Research Council
   (RPG 238805 to R. T. Hepple), and the National Center for Research
   Resources of the National Institutes of Health to L. G. Koch and S. L.
   Britton (R24 RR017718). Expert care of the LCR and HCR rat colony was
   provided by Lori Gilligan. A. Safdar was supported by a Doctoral Award
   from the Canadian Institutes of Health Research, R. T. Hepple was
   supported by a Senior Scholar Award from the Alberta Heritage Foundation
   for Medical Research, and Y. Burelle was supported by a Chercher
   Boursier Junior II Award from Fonds de Recherche en Sante du Quebec.
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NR 74
TC 49
Z9 57
U1 0
U2 14
PU AMER PHYSIOLOGICAL SOC
PI Rockville
PA 6120 Executive Blvd, Suite 600, Rockville, MD, UNITED STATES
SN 0363-6119
EI 1522-1490
J9 AM J PHYSIOL-REG I
JI Am. J. Physiol.-Regul. Integr. Comp. Physiol.
PD MAR
PY 2011
VL 300
IS 3
BP R544
EP R553
DI 10.1152/ajpregu.00250.2010
PG 10
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA 730XE
UT WOS:000288069900003
PM 21148474
OA Green Accepted, Green Published
DA 2025-06-11
ER

PT J
AU Roberts, JM
   Hubel, CA
AF Roberts, J. M.
   Hubel, C. A.
TI The Two Stage Model of Preeclampsia: Variations on the Theme
SO PLACENTA
LA English
DT Article; Proceedings Paper
CT 14th Meeting of the
   International-Federation-of-Placental-Associations/12th Meeting of the
   European-Placenta-Group (IFPA/EPG)
CY SEP 10-13, 2008
CL Seggau Castle, AUSTRIA
SP Int Federat Placenta Assoc, European Placenta Grp
DE Preeclampsia; Implantation; Placentation; Intrauterine growth
   restriction; Subtypes; Cardiovascular disease; Metabolic syndrome;
   Preterm birth
ID UTERINE ARTERY DOPPLER; ENDOTHELIAL DYSFUNCTION; NORMAL-PREGNANCY;
   TYROSINE KINASE-1; OXIDATIVE STRESS; LONG PENTRAXIN-3; HIGHER RISK;
   PLASMA; WOMEN; 2ND-TRIMESTER
AB The Two Stage Model of preeclampsia proposes that a poorly perfused placenta (Stage 1) produces factor(s) leading to the clinical manifestations of preeclampsia (Stage 2). Stage I is not sufficient to cause the maternal syndrome but interacts with maternal constitutional factors (genetic, behavioral or environmental) to result in Stage 2. Recent information indicates the necessity for modifications of this model. It is apparent that changes relevant to preeclampsia and other implantation disorders can be detected in the first trimester, long before the failed vascular remodeling necessary to reduce placental perfusion is completed. In addition, although the factor(s) released from the placenta has usually been considered a toxin, we suggest that what is released may also be an appropriate signal from the fetal/placental unit to overcome reduced nutrient availability that cannot be tolerated by some women who develop preeclampsia. Further, it is evident that linkage is not likely to be one factor but several, different for different women. Also although the initial model limited the role of maternal constitutional factors to the genesis of Stage 2, this does not appear to be the case. It is evident that the factors increasing risk for preeclampsia are also associated with abnormal implantation. These several modifications have important implications. An earlier origin for Stage 1, which appears to be recognizable by altered concentrations of placental products, could allow earlier intervention. The possibility of a fetal placental factor increasing nutrient availability could provide novel therapeutic options. Different linkages and preeclampsia subtypes could direct specific preventive treatments for different women while the role of maternal constitutional factors to affect placentation provides targets for prepregnancy therapy. The modified Two Stage Model provides a useful guide towards investigating pathophysiology and guiding therapy. (C) 2009 Published by IFPA and Elsevier Ltd.
C1 [Roberts, J. M.; Hubel, C. A.] Univ Pittsburgh, Magee Womens Res Inst, Pittsburgh, PA 15213 USA.
   [Roberts, J. M.; Hubel, C. A.] Univ Pittsburgh, Dept Obstet Gynecol & Reprod Sci, Pittsburgh, PA USA.
   [Roberts, J. M.] Univ Pittsburgh, Dept Epidemiol, Pittsburgh, PA 15261 USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE); University
   of Pittsburgh; Magee-Womens Research Institute; Pennsylvania
   Commonwealth System of Higher Education (PCSHE); University of
   Pittsburgh; Pennsylvania Commonwealth System of Higher Education
   (PCSHE); University of Pittsburgh
RP Roberts, JM (corresponding author), Univ Pittsburgh, Magee Womens Res Inst, 204 Craft Ave, Pittsburgh, PA 15213 USA.
EM jroberts@mwri.magee.edu
RI Roberts, James/AAI-3283-2020
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NR 43
TC 539
Z9 559
U1 0
U2 46
PU W B SAUNDERS CO LTD
PI LONDON
PA 32 JAMESTOWN RD, LONDON NW1 7BY, ENGLAND
SN 0143-4004
EI 1532-3102
J9 PLACENTA
JI Placenta
PD MAR
PY 2009
VL 30
SU A
BP S32
EP S37
DI 10.1016/j.placenta.2008.11.009
PG 6
WC Developmental Biology; Obstetrics & Gynecology; Reproductive Biology
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Developmental Biology; Obstetrics & Gynecology; Reproductive Biology
GA 419UK
UT WOS:000264245000007
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Hsieh, MC
   Tien, KJ
   Chang, SJ
   Perng, DS
   Hsiao, JY
   Chen, YW
   Chang, YH
   Kuo, HW
   Lin, PC
AF Hsieh, Ming-Chia
   Tien, Kai-Jen
   Chang, Shun-Jen
   Perng, Daw-Shyong
   Hsiao, Jeng-Yueh
   Chen, Yu-Wen
   Chang, Yu-Hung
   Kuo, Hsuan-Wen
   Lin, Pi-Chen
TI High-sensitivity C-reactive protein and silent myocardial ischemia in
   Chinese with type 2 diabetes mellitus
SO METABOLISM-CLINICAL AND EXPERIMENTAL
LA English
DT Article
ID CORONARY-ARTERY-DISEASE; EMISSION COMPUTED-TOMOGRAPHY; CHOLESTEROL
   EDUCATION-PROGRAM; INCREMENTAL PROGNOSTIC VALUE; EXERCISE STRESS TEST;
   CARDIOVASCULAR-DISEASE; HEART-DISEASE; METABOLIC SYNDROME; PERFUSION
   SPECT; RISK-FACTORS
AB Coronary artery disease (CAD) is a major cause of morbidity and mortality in patients with type 2 diabetes mellitus. When diabetes exists in patients with established CAD, absolute risk for future events is very high. Diabetic patients often have severe, yet asymptomatic, CAD. Although high-sensitivity C-reactive protein (hsCRP) is a strong independent risk factor for cardiovascular events, there is an unclear association between it and silent myocardial ischemia in diabetic patients. In this study, we assess the relationship between hsCRP and silent myocardial ischemia in Chinese with type 2 diabetes mellitus. We designed a cross-sectional study with 225 asymptomatic diabetic patients having no known CAD. Ischemia was assessed by myocardial perfusion imaging. A total of 109 patients (48.4%) was found to have silent myocardial ischemia. Logistic regression analysis revealed age (odds ratio = 4.01, P =.002) (95% confidence interval, 1.98-7.44) and hsCRP (odds ratio = 2.58, P =.005) (95% confidence interval, 1.33-5.0 1) to be associated with greater risk of silent myocardial ischemia. Using the American Diabetes Association screening guidelines to evaluate risk, we found silent myocardial ischemia to be equally distributed between diabetic patients with 2 or more cardiac risk factors and those with less than 2 risk factors. Twenty-seven (24.8%) patients with silent myocardial ischemia were missed when the American Diabetes Association guidelines were used alone. High-sensitivity C-reactive protein was associated with silent myocardial ischemia in our study. High-sensitivity C-reactive protein might help detect silent myocardial ischemia in diabetic Chinese who may need aggressive treatment to reduce future CAD morbidity and mortality in Taiwan. (C) 2008 Elsevier Inc. All rights reserved.
C1 [Hsieh, Ming-Chia; Hsiao, Jeng-Yueh; Chang, Yu-Hung; Kuo, Hsuan-Wen; Lin, Pi-Chen] Kaohsiung Med Univ, Chung Ho Mem Hosp, Div Endocrinol & Metab, Dept Internal Med, Kaohsiung 80756, Taiwan.
   [Tien, Kai-Jen] Chi Mei Med Ctr, Div Endocrinol & Metab, Dept Internal Med, Tainan, Taiwan.
   [Chang, Shun-Jen] Kaohsiung Med Coll, Fac Med, Dept Publ Hlth, Kaohsiung, Taiwan.
   [Perng, Daw-Shyong] I Shou Univ, E Da Hosp, Kaohsiung, Taiwan.
   [Chen, Yu-Wen] Kaohsiung Med Univ, Chung Ho Mem Hosp, Dept Nucl Med, Kaohsiung, Taiwan.
C3 Kaohsiung Medical University; Kaohsiung Medical University Hospital; Chi
   Mei Hospital; Kaohsiung Medical University; I Shou University; E-Da
   Hospital; Kaohsiung Medical University; Kaohsiung Medical University
   Hospital
RP Hsieh, MC (corresponding author), Kaohsiung Med Univ, Chung Ho Mem Hosp, Div Endocrinol & Metab, Dept Internal Med, Kaohsiung 80756, Taiwan.
EM minga0531@gmail.com
RI Hsieh, Ming-Chia/D-4518-2009; Chang, Shun-Jen/D-5501-2009; Chang, Yu
   Hung/F-8176-2011
OI Chang, Yu Hung/0000-0001-6116-1893
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NR 48
TC 11
Z9 14
U1 0
U2 1
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0026-0495
EI 1532-8600
J9 METABOLISM
JI Metab.-Clin. Exp.
PD NOV
PY 2008
VL 57
IS 11
BP 1533
EP 1538
DI 10.1016/j.metabol.2008.06.007
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 368SC
UT WOS:000260641800008
PM 18940390
DA 2025-06-11
ER

PT J
AU Toblli, JE
   Cao, G
   Rivas, C
   DeRosa, G
   Domecq, P
AF Toblli, Jorge Eduardo
   Cao, Gabriel
   Rivas, Carlos
   DeRosa, Graciela
   Domecq, Patricia
TI Angiotensin-converting enzyme inhibition reduces lipid deposits in
   myocardium and improves left ventricular function of obese Zucker rats
SO OBESITY
LA English
DT Article
DE cardiac steatosis; angiotensin-converting enzyme inhibitor; amlodipine;
   Zucker rats
ID SPONTANEOUSLY HYPERTENSIVE-RATS; CARDIAC CONTRACTILE RESPONSE;
   ATTENUATES OXIDATIVE STRESS; HEART-FAILURE; ECHOCARDIOGRAPHIC
   ASSESSMENT; LEPTIN RESISTANCE; NITRIC-OXIDE; ENDOTHELIAL FUNCTION;
   METABOLIC SYNDROME; RENAL-FAILURE
AB Objective: Alterations in the renin angiotensin system, cardiac lipotoxicity, and left ventricular (LV) dysfunction have been reported in obese rats. The present study examined whether angiotensin-converting enzyme inhibition could ameliorate lipid deposition and ventricular function in the myocardium of obese Zucker rats (OZRs).
   Research Methods and Procedures: For 6 months, rats were treated as follows: Group (G) 1, OZR, no treatment; G2, OZR + ramipril (R); G3, OZR + amlodipine (AML); and G4, lean Zucker rats. LV function was assessed by echocardiogram and lipid deposits in cardiomyocytes (LDCM) by light microscopy using Oil red O.
   Results: At the end of the experiment, both OZR + R and OZR + AML groups presented similar reduction in blood pressure in comparison with untreated OZR (p < 0.01). OZR with R presented lower insulin-to-glucose ratio and lower serum triglycerides and cholesterol when compared with both untreated OZR and OZR with AML (p < 0.01). Fractional shortening by echocardiogram was as follows: G1, 25.4 +/- 3.8 (vs. G2 and G4, p < 0.05); G2, 37.2 +/- 2.4; G3, 29.3 +/- 4.4 (vs. G2 and G4, p < 0.05); and G4, 40.8 +/- 2.3. Percentage LDCM was as follows: G1, 12.4 +/- 2.7 (vs. G2 and G4, p < 0.05); G2, 0.8 +/- 0.2; G3, 11.1 +/- 2.1 (vs. G2 and G4, p < 0.05); and G4, 0.1 +/- 0.1. There was a negative correlation between fractional shortening and LDCM percentage in OZR (r = -0.93) and in OZR + AML (r = -0.87).
   Discussion: AML reduced blood pressure significantly; however, it failed to modify both metabolic parameters and LDCM. In contrast, R showed a substantial reduction in LDCM, together with LV function preservation.
C1 Hosp Aleman, Expt Med Lab, CONICET, RA-1118 Buenos Aires, DF, Argentina.
C3 Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET);
   University of Buenos Aires; University of Buenos Aires Hospital;
   Hospital Aleman
RP Toblli, JE (corresponding author), Hosp Aleman, Expt Med Lab, CONICET, Av Pueyrredon 1640, RA-1118 Buenos Aires, DF, Argentina.
EM jtoblli@hospitalaleman.com
RI Cao, Gabriel/LJL-8755-2024
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NR 61
TC 8
Z9 13
U1 1
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1930-7381
EI 1930-739X
J9 OBESITY
JI Obesity
PD SEP
PY 2006
VL 14
IS 9
BP 1586
EP 1595
DI 10.1038/oby.2006.183
PG 10
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 097QG
UT WOS:000241462500016
PM 17030970
DA 2025-06-11
ER

PT J
AU Naidoo, K
   Khathi, A
AF Naidoo, Karishma
   Khathi, Andile
TI Investigating the Effects of Gossypetin on Cardiovascular Function in
   Diet-Induced Pre-Diabetic Male Sprague Dawley Rats
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE Gossypetin; natural flavonoid; cardiovascular; diet-induced pre-diabetes
ID OXIDATIVE STRESS; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   DIABETES-MELLITUS; METFORMIN IMPROVES; HIGH-FAT; DISEASE; MARKERS;
   PROFILE; RISK
AB Gossypetin (GTIN) is a naturally occurring flavonoid recognised for its pharmacological properties. This study examined the effects of GTIN on cardiovascular function in a diet-induced pre-diabetic rat model, which has not been previously studied. Pre-diabetes was induced using a high-fat high-carbohydrate (HFHC) diet supplemented with 15% fructose water for 20 weeks. Thereafter, the pre-diabetic animals were sub-divided into five groups (n = 6), where they were either orally treated with GTIN (15 mg/kg) or metformin (MET) (500 mg/kg), both in the presence and absence of dietary intervention for 12 weeks. The results demonstrated that the pre-diabetic (PD) control group exhibited significantly higher plasma triglyceride, total cholesterol, low-density lipoprotein and very low-density lipoprotein levels, along with decreased high-density lipoprotein (HDL) levels in comparison to the non-pre-diabetic (NPD) group. This was accompanied by significantly higher mean arterial pressure (MAP), body mass index (BMI), waist circumference (WC) and plasma endothelial nitric oxide (eNOS) levels in PD control. Additionally, there were increased heart malondialdehyde levels, reduced heart superoxide dismutase and glutathione peroxidase activity as well as increased plasma interleukin-6, tumour necrosis factor alpha and c-reactive protein levels present in the PD control group. Notably, both GTIN-treated groups showed significantly reduced plasma lipid levels and increased HDL, as well as decreases in MAP, BMI, WC and eNOS levels in comparison to PD control. Additionally, GTIN significantly decreased heart lipid peroxidation, enhanced antioxidant activity and decreased plasma inflammation markers. These findings may suggest that GTIN administration in both the presence and absence of dietary intervention may offer therapeutic potential in ameliorating cardiovascular disturbances associated with the PD state. However, future studies are needed to determine the physiological mechanisms by which GTIN improves cardiovascular function in the PD state.
C1 [Naidoo, Karishma; Khathi, Andile] Univ KwaZulu Natal, Coll Hlth Sci, Sch Lab Med & Med Sci, Dept Human Physiol, ZA-4000 Durban, South Africa.
C3 University of Kwazulu Natal
RP Khathi, A (corresponding author), Univ KwaZulu Natal, Coll Hlth Sci, Sch Lab Med & Med Sci, Dept Human Physiol, ZA-4000 Durban, South Africa.
EM karishma280199@gmail.com; khathia@ukzn.ac.za
RI Khathi, Andile/S-9664-2019
OI Khathi, Andile/0000-0002-2246-0038; Naidoo, Karishma/0000-0002-3601-6333
FU National Research Foundation (South Africa);  [UID 140586]
FX This research was funded by the National Research Foundation (South
   Africa), grant number UID 140586.
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NR 134
TC 1
Z9 1
U1 0
U2 0
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD NOV
PY 2024
VL 25
IS 22
AR 12105
DI 10.3390/ijms252212105
PG 16
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA N6M0R
UT WOS:001365445700001
PM 39596174
OA gold
DA 2025-06-11
ER

PT J
AU Lambova, SN
AF Lambova, Sevdalina Nikolova
TI Pleiotropic Effects of Metformin in Osteoarthritis
SO LIFE-BASEL
LA English
DT Review
DE osteoarthritis; metformin
ID ANTIDIABETIC DRUG; SIGNALING PATHWAY; MAMMALIAN TARGET; OLD DRUG; KNEE;
   LEPTIN; ACTIVATION; PAIN; AMPK; HYPERSENSITIVITY
AB The involvement of the knee joint is the most common localization of the pathological process in osteoarthritis (OA), which is associated with obesity in over 50% of the patients and is mediated by mechanical, inflammatory, and metabolic mechanisms. Obesity and the associated conditions (hyperglycemia, dyslipidemia, and hypertension) have been found to be risk factors for the development of knee OA, which has led to the emerging concept of the existence of a distinct phenotype, i.e., metabolic knee OA. Combined assessment of markers derived from dysfunctional adipose tissue, markers of bone and cartilage metabolism, as well as high-sensitivity inflammatory markers and imaging, might reveal prognostic signs for metabolic knee OA. Interestingly, it has been suggested that drugs used for the treatment of other components of the metabolic syndrome may also affect the clinical course and retard the progression of metabolic-associated knee OA. In this regard, significant amounts of new data are accumulating about the role of metformin-a drug, commonly used in clinical practice with suggested multiple pleiotropic effects. The aim of the current review is to analyze the current views about the potential pleiotropic effects of metformin in OA. Upon the analysis of the different effects of metformin, major mechanisms that might be involved in OA are the influence of inflammation, oxidative stress, autophagy, adipokine levels, and microbiome modulation. There is an increasing amount of evidence from in vitro studies, animal models, and clinical trials that metformin can slow OA progression by modulating inflammatory and metabolic factors that are summarized in the current up-to-date review. Considering the contemporary concept about the existence of metabolic type knee OA, in which the accompanying obesity and systemic low-grade inflammation are suggested to influence disease course, metformin could be considered as a useful and safe component of the personalized therapeutic approach in knee OA patients with accompanying type II diabetes or obesity.
C1 [Lambova, Sevdalina Nikolova] Med Univ Plovdiv, Fac Med, Dept Propaedeut Internal Dis Prof Dr Anton Mitov, Plovdiv 4002, Bulgaria.
   [Lambova, Sevdalina Nikolova] MHAT Sveti Mina, Dept Rheumatol, Plovdiv 4002, Bulgaria.
C3 Medical University Plovdiv
RP Lambova, SN (corresponding author), Med Univ Plovdiv, Fac Med, Dept Propaedeut Internal Dis Prof Dr Anton Mitov, Plovdiv 4002, Bulgaria.; Lambova, SN (corresponding author), MHAT Sveti Mina, Dept Rheumatol, Plovdiv 4002, Bulgaria.
EM sevdalina_n@abv.bg
RI Lambova, Sevdalina/I-2386-2019
OI Lambova, Sevdalina/0000-0002-1321-6770
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NR 72
TC 7
Z9 7
U1 0
U2 11
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2075-1729
J9 LIFE-BASEL
JI Life-Basel
PD FEB
PY 2023
VL 13
IS 2
AR 437
DI 10.3390/life13020437
PG 12
WC Biology; Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics; Microbiology
GA 9J3SV
UT WOS:000940111800001
PM 36836794
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Jam, SA
   Rezaeian, S
   Najafi, F
   Hamzeh, B
   Shakiba, E
   Moradinazar, M
   Darbandi, M
   Hichi, F
   Eghtesad, S
   Pasdar, Y
AF Jam, Samira Arbabi
   Rezaeian, Shahab
   Najafi, Farid
   Hamzeh, Behrooz
   Shakiba, Ebrahim
   Moradinazar, Mehdi
   Darbandi, Mitra
   Hichi, Fatemeh
   Eghtesad, Sareh
   Pasdar, Yahya
TI Association of a pro-inflammatory diet with type 2 diabetes and
   hypertension: results from the Ravansar non-communicable diseases cohort
   study
SO ARCHIVES OF PUBLIC HEALTH
LA English
DT Article
DE Dietary inflammatory index; Pro-inflammatory diet; Hypertension; Type 2
   diabetes; Persian
ID C-REACTIVE PROTEIN; SYSTEMIC INFLAMMATION; MEDITERRANEAN DIET;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; MELLITUS; PATTERNS; MARKERS;
   STRESS; RISK
AB Background Most non-communicable diseases (NCDs) are associated to diet and inflammation. The Dietary Inflammatory Index (DII) is a developed and validated self-assessment tool. The study was conducted to assess the association of DII with the hypertension (HTN) and type 2 diabetes mellitus (T2DM). Methods This cross-sectional analysis was conducted on 9811 participants aged 35 to 65 years from the Ravansar Non-Communicable Diseases (RaNCD) cohort study's baseline phase data. The DII was calculated using 31 food frequency questionnaire parameters (FFQ). Univariable and multiple logistic regression was used to derive the estimates. Results In healthy participants, the mean DII score was - 2.32 +/- 1.60; in participants with T2DM, HTN, or T2DM&HTN, the mean DII score was - 2.23 +/- 1.59, - 2.45 +/- 1.60 and - 2.25 +/- 1.60, respectively (P = 0.011). Males had a significantly higher pro-inflammatory diet than females (P < 0.001). BMI (body mass index), triglyceride, energy intake, smokers were significantly higher and socio-economic status (SES), physical activity and HDL-C were significantly lower in the most pro-inflammatory diet compared to the most anti-inflammatory diet. Participants with T2DM, HTN, and T2DM&HTN had significantly higher mean anthropometry indices (P < 0.001) and lipid profiles than healthy subjects (P < 0.001). After adjusting for age, gender, and physical activity, the probability of developing T2DM was 1.48 (95% CI: 1.19, 1.85) times greater in the fourth quartile of DII than in the first quartile. Conclusions The findings of this study showed that an anti-inflammatory diet are associated with HTN, T2DM, and the risk factors associated with these conditions. Modification of diet is recommended to reduce inflammation.
C1 [Jam, Samira Arbabi] Kermanshah Univ Med Sci, Student Res Comm, Kermanshah, Iran.
   [Rezaeian, Shahab; Hamzeh, Behrooz; Moradinazar, Mehdi; Darbandi, Mitra; Pasdar, Yahya] Kermanshah Univ Med Sci, Res Ctr Environm Determinants Hlth RCEDH, Hlth Inst, Kermanshah, Iran.
   [Rezaeian, Shahab] Kermanshah Univ Med Sci, Infect Dis Res Ctr, Kermanshah, Iran.
   [Najafi, Farid] Kermanshah Univ Med Sci, Cardiovasc Res Ctr, Kermanshah, Iran.
   [Shakiba, Ebrahim] Kermanshah Univ Med Sci, Behav Dis Res Ctr, Kermanshah, Iran.
   [Hichi, Fatemeh] Kermanshah Univ Med Sci, Sch Med, Internal Med Dept, Kermanshah, Iran.
   [Eghtesad, Sareh] Univ Tehran Med Sci, Liver & Pancreatobiliary Res Ctr, Digest Dis Res Inst, Tehran, Iran.
   [Pasdar, Yahya] Sch Nutr Sci & Food Technol, Nutr Sci Dept, Isar Sq, Tehran, Iran.
C3 Kermanshah University of Medical Sciences; Kermanshah University of
   Medical Sciences; Kermanshah University of Medical Sciences; Kermanshah
   University of Medical Sciences; Kermanshah University of Medical
   Sciences; Kermanshah University of Medical Sciences; Tehran University
   of Medical Sciences
RP Pasdar, Y (corresponding author), Kermanshah Univ Med Sci, Res Ctr Environm Determinants Hlth RCEDH, Hlth Inst, Kermanshah, Iran.; Pasdar, Y (corresponding author), Sch Nutr Sci & Food Technol, Nutr Sci Dept, Isar Sq, Tehran, Iran.
EM yahya.pasdar@kums.ac.ir
RI Rezaeian, Shahab/G-7482-2011; Moradinazar, Mehdi/N-2129-2017; Pasdar,
   Yahya/J-9064-2017; Shakiba, Ebrahim/R-9984-2017; Najafi,
   Farid/JSL-1581-2023; Hamzeh, Behrooz/S-6852-2017
OI Pasdar, Yahya/0000-0001-8682-5721
FU Kermanshah University of Medical Sciences [92472]
FX This research was supported by Kermanshah University of Medical Sciences
   (grant number: 92472).
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NR 37
TC 8
Z9 8
U1 3
U2 10
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0778-7367
EI 2049-3258
J9 ARCH PUBLIC HEALTH
JI Arch. PUblic Health
PD MAR 31
PY 2022
VL 80
IS 1
AR 102
DI 10.1186/s13690-022-00839-w
PG 8
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA 0E8MC
UT WOS:000776927700003
PM 35361279
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU van Leeuwen, WMA
   Pekcan, C
   Barnett, M
   Kecklund, G
AF van Leeuwen, Wessel M. A.
   Pekcan, Claire
   Barnett, Mike
   Kecklund, Goran
TI Mathematical modelling of sleep and sleepiness under various watch
   keeping schedules in the maritime industry
SO MARINE POLICY
LA English
DT Article
DE Sleep; Sleepiness; Fatigue; Watchkeeping; Sleepiness modelling
ID ROTATING SHIFT-WORK; INDIVIDUAL-DIFFERENCES; METABOLIC SYNDROME;
   FATIGUE; WAKEFULNESS; PERFORMANCE; SEAFARERS; DEMANDS; STRESS; FIELD
AB Ships typically operate on a 24/7 basis giving rise to a wide variety of working time arrangements and watch keeping schedules. Typically, these can be divided into 2-watch systems (where two watch keepers/teams share the 24-h period) and 3-watch systems (where three watch keepers/teams share the 24-h period). The current study uses the three-process model of alertness regulation to compare these systems in terms of the amount of severe sleepiness that is predicted to take place on watch and the amount of sleep that is predicted to occur while off watch. Separate predictions are calculated for individuals characterised as morning and evening chronotypes. Comparing 2-watch systems, highest levels of severe sleepiness were seen for evening types working 0000-1200 within the 12on12off system. The longest sleep per 24 h day was also found for evening types, but for those working the 1200-0000 watch within the 12on12off system. Total daily sleep duration ranged between 268 and 445 min. However, the picture is complex and the lowest risk of severe sleepiness while on watch is not necessarily correlated with the maximal time available for rest and recuperation when off watch. For 3-watch systems, the "five-and-dime" system (changeover times: 02-07-12-17-22) stands out having the lowest prevalence of severe sleepiness on watch and the longest amount of predicted daily sleep off watch. Considerable differences exist between morning and evening types offering the opportunity for considerable improvement in sleep amount for fixed (but not rotating) systems when individual chronotype is considered in watch scheduling. It is concluded that 3-watch systems, although economically costlier, have clear advantages over 2-watch systems, but that a perfect system that fits all does not exist due to the considerable impact of individual differences related to sleep/wake regulation.
C1 [van Leeuwen, Wessel M. A.; Kecklund, Goran] Stockholm Univ, Stress Res Inst, SE-10691 Stockholm, Sweden.
   [Pekcan, Claire] Safe Marine Ltd, Southampton SO31 5BR, Hants, England.
   [Barnett, Mike] MLB Maritime Serv Ltd, Southampton SO18 3PS, Hants, England.
C3 Stockholm University
RP van Leeuwen, WMA (corresponding author), Stockholm Univ, Stress Res Inst, SE-10691 Stockholm, Sweden.
EM wessel.vleeuwen@su.se
RI ; van Leeuwen, Wessel M.A./A-5812-2019
OI Pekcan, Claire/0000-0002-3550-0465; van Leeuwen, Wessel
   M.A./0000-0003-0834-0811
FU UK Maritime and Coastguard Agency
FX This work was supported by the UK Maritime and Coastguard Agency.
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NR 55
TC 13
Z9 13
U1 3
U2 13
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0308-597X
EI 1872-9460
J9 MAR POLICY
JI Mar. Pol.
PD AUG
PY 2021
VL 130
AR 104277
DI 10.1016/j.marpol.2020.104277
EA JUN 2021
PG 9
WC Environmental Studies; International Relations
WE Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; International Relations
GA TE7HR
UT WOS:000670179900009
DA 2025-06-11
ER

PT J
AU Bazyar, H
   Javid, AZ
   Behbahani, HB
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AF Bazyar, Hadi
   Zare Javid, Ahmad
   Bavi Behbahani, Hossein
   Moradi, Fardin
   Moradi Poode, Bahman
   Amiri, Parichehr
TI Consumption of melatonin supplement improves cardiovascular disease risk
   factors and anthropometric indices in type 2 diabetes mellitus patients:
   a double-blind, randomized, placebo-controlled trial
SO TRIALS
LA English
DT Article
DE Type 2 diabetes mellitus; Melatonin; Blood pressure; New anthropometric
   indices
ID HIGH-FAT DIET; BLOOD-PRESSURE; POSTMENOPAUSAL WOMEN; METABOLIC SYNDROME;
   ATHEROGENIC INDEX; OXIDATIVE STRESS; ADIPOSE-TISSUE; BODY-WEIGHT;
   OBESITY; HEALTH
AB Background: Diabetes mellitus is a common chronic disease. Dyslipidemia and hypertension are two complications that may develop in diabetic patients if hyperglycemia, insulin resistance, and weight gain are not controlled. This study investigated the effects of melatonin supplementation on some cardiovascular disease risk factors and anthropometric indices in patients with type 2 diabetes mellitus (T2DM).
   Materials and methods: In this double-blind, randomized, placebo-controlled trial, 50 T2DM patients were randomly allocated to intervention and control groups which received two tablets of either melatonin or placebo (250 mg) once a day for 8 weeks. Systolic blood pressure (SBP), mean arterial pressure (MAP), pulse pressure (PP), the atherogenic index of plasma (AIP), weight, body mass index (BMI), waist and hip circumference (WC, HC), a body shape index (ABSI), abdominal volume index (AVI), body adiposity index (BAI), lipid accumulation product (LAP), conicity index, and waist-to-height ratio (WHtR) were evaluated in all the patients pre- and post-intervention.
   Results: Melatonin supplementation for 8 weeks significantly decreased the mean levels of SBP, MAP, PP, weight, BMI, WC, HC, BAI, AVI, conicity index, and WHtR post-intervention (p < 0.05). Also, the median changes of SBP, MAP, PP, weight, BMI, WC, HC BAI, AVI, and conicity index were significantly lower in the intervention group compared with the control group (p < 0.05). A significant increase (p < 0.001) was observed in the mean levels of ABSI in the intervention group. The median changes of ABSI were significantly greater in the intervention group compared with the control group (p < 0.001).
   Conclusions: Consumption of melatonin supplement may be effective in controlling arterial pressure including SBP, MAP, and PP and anthropometric indices (as predictors of obesity) in T2DM patients.
C1 [Bazyar, Hadi; Bavi Behbahani, Hossein; Moradi Poode, Bahman; Amiri, Parichehr] Ahvaz Jundishapur Univ Med Sci, Student Res Comm, Ahvaz, Iran.
   [Bazyar, Hadi; Zare Javid, Ahmad] Ahvaz Jundishapur Univ Med Sci, Sch Allied Med Sci, Dept Nutr, Ahvaz, Iran.
   [Moradi, Fardin] Tabriz Univ Med Sci, Student Res Comm, Tabriz, Iran.
C3 Ahvaz Jundishapur University of Medical Sciences (AJUMS); Ahvaz
   Jundishapur University of Medical Sciences (AJUMS); Tabriz University of
   Medical Science
RP Amiri, P (corresponding author), Ahvaz Jundishapur Univ Med Sci, Student Res Comm, Ahvaz, Iran.
EM amiriparichehr70@gmail.com
RI Amiri, Parichehr/ABA-8596-2021; Zare Javid, Ahmad/AAA-8366-2022; bazyar,
   hadi/AFG-3161-2022
OI bazyar, hadi/0000-0002-1627-7122
FU Student Research Committee of Ahvaz Jundishapur University of Medical
   Sciences [97s43]
FX This research project was sponsored by the Student Research Committee of
   Ahvaz Jundishapur University of Medical Sciences (97s43).
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NR 53
TC 21
Z9 21
U1 2
U2 11
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1745-6215
J9 TRIALS
JI Trials
PD MAR 25
PY 2021
VL 22
IS 1
AR 231
DI 10.1186/s13063-021-05174-z
PG 10
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA RF9RS
UT WOS:000635175900002
PM 33766084
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Sezavar, H
   Yousefi, R
   Abbasi, M
   Safari, S
   Mottaghi, A
AF Sezavar, Hashem
   Yousefi, Reyhaneh
   Abbasi, Mehrnaz
   Safari, Saeed
   Mottaghi, Azadeh
TI Anthropometric and Biochemical Measures in Bariatric Surgery Candidates:
   What Is the Role of Inflammatory Potential of Diet?
SO OBESITY SURGERY
LA English
DT Article
DE Dietary total antioxidant capacity; Dietary phytochemical intake;
   Dietary inflammatory index; Patients with morbid obesity; Bariatric
   surgery; Anthropometric; Biochemical
ID TOTAL ANTIOXIDANT CAPACITY; 3-YEAR FOLLOW-UP; PHYTOCHEMICAL INDEX;
   METABOLIC SYNDROME; CARDIOVASCULAR-DISEASE; NUTRIENT DEFICIENCIES;
   AMERICAN ASSOCIATION; PROSPECTIVE COHORT; OXIDATIVE STRESS; RISK-FACTORS
AB Background The present study aimed to assess dietary total antioxidant capacity (TAC), dietary phytochemical intake (PI), and dietary inflammatory index (DII) in patients with morbid obesity who are candidates of bariatric surgery and their association with anthropometric and biochemical parameters.
   Methods and Materials One hundred seventy patients with morbid obesity who were referred to surgery clinic of Firoozgar Hospital were enrolled in the study. Ideal body weight and adjusted ideal body weight were calculated. The dietary data were collected using a food frequency questionnaire. Anthropometrics and biochemical parameters were assessed. A p-value of <0.05 was considered significant.
   Results The strongest correlations of DII with dietary intakes and anthropometric and biochemical biomarkers were found for iron (p<0.0001). Significant association was also observed for ferritin (p=0.02) and transferrin (p=0.02). In terms of PI, The strongest associations were also found for iron (p<0.0001). Additionally, the value of body mass index (BMI) showed significant correlation with PI (p=0.04). The correlations of dietary total antioxidant indices with dietary intakes and anthropometric and biochemical biomarkers were assessed. Non-significant correlation was found between fasting blood sugar (FBS), hemoglobin A1C (HbA1C), vitamin B12, and vitamin D3 with ORAC index. Significant strong correlation showed for the value of iron in both ferric reducing ability of plasma (FRAP) and Oxygen Radical Absorbance Capacity (ORAC) indices (p<0.0001).
   Conclusion We find statistical significance correlation for dietary PI and BMI. The inflammatory and antioxidant properties of diet were not related to biochemical markers associated with obesity.
C1 [Sezavar, Hashem; Mottaghi, Azadeh] Iran Univ Med Sci, Inst Endocrinol & Metab, Res Ctr Prevent Cardiovasc Dis, Tehran, Iran.
   [Yousefi, Reyhaneh] Concordia Univ, Dept Hlth Kinesiol & Appl Physiol, Montreal, PQ, Canada.
   [Yousefi, Reyhaneh] Hop Sacre Coeur Montreal, Montreal Behav Med Ctr, Montreal, PQ, Canada.
   [Abbasi, Mehrnaz] Arizona State Univ, Coll Hlth Solut, Phoenix, AZ 85004 USA.
   [Safari, Saeed] Iran Univ Med Sci, Tehran, Iran.
C3 Iran University of Medical Sciences; Concordia University - Canada;
   Universite de Montreal; Arizona State University; Arizona State
   University-Downtown Phoenix; Iran University of Medical Sciences
RP Mottaghi, A (corresponding author), Iran Univ Med Sci, Inst Endocrinol & Metab, Res Ctr Prevent Cardiovasc Dis, Tehran, Iran.
EM sezavar.h@iums.ac.ir; yousefi.ryhn@gmail.com; mehrnaz.abbasi@asu.edu;
   saeedsfr@gmail.com; mottaghi.a@iums.ac.ir
RI Mottaghi, Azadeh/AAP-6399-2021; Abbasi, Mehrnaz/AAF-5856-2019; Yousefi,
   Reyhaneh/AFF-9809-2022; Mottaghi, Azadeh/P-3177-2018
OI Mottaghi, Azadeh/0000-0002-1325-8946
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NR 67
TC 1
Z9 1
U1 0
U2 3
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0960-8923
EI 1708-0428
J9 OBES SURG
JI Obes. Surg.
PD JUL
PY 2021
VL 31
IS 7
BP 3097
EP 3108
DI 10.1007/s11695-021-05345-6
EA MAR 2021
PG 12
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA SM9IZ
UT WOS:000631300200001
PM 33751340
DA 2025-06-11
ER

PT J
AU Brzezinski, RY
   Friedensohn, L
   Shapira, I
   Zeltser, D
   Rogowski, O
   Berliner, S
   Grupper, A
   Shenhar-Tsarfaty, S
AF Brzezinski, Rafael Y.
   Friedensohn, Limor
   Shapira, Itzhak
   Zeltser, David
   Rogowski, Ori
   Berliner, Shlomo
   Grupper, Ayelet
   Shenhar-Tsarfaty, Shani
TI Exercise-induced albuminuria increases over time in individuals with
   impaired glucose metabolism
SO CARDIOVASCULAR DIABETOLOGY
LA English
DT Article
DE Albuminuria; Blood glucose; Diabetes; Endothelial dysfunction; Exercise
ID MANAGEMENT; OUTCOMES
AB BackgroundExercise induced albuminuria (EiA) is elevated in patients with metabolic dysfunction and diabetes, and may serve as an early biomarker for endothelial dysfunction and "kidney reserve". However, the change in EiA levels over time and its interaction with metabolic dysfunction and glucose metabolism has never been studied. Therefore, we sought to determine EiA levels over time in a cohort of individuals attending a routine annual health survey.MethodsWe prospectively enrolled 412 patients attending an annual healthy survey at our Medical Center. We collected urine samples for albumin and creatinine measurements before and immediately after completing an exercise stress test, along with multiple physiologic and metabolic parameters. Participants returned to a second follow up visit after a mean follow up period of 3 years (1.7 SD).ResultsPatients with diagnosed diabetes and subjects with HbA1c >= 6.5% significantly increased their EiA over time (median [IQR] change between visits=19.5 [-10.4-56.1] vs. -1.1 [-12.7-4.9] (p=0.049) for diabetics vs non-diabetics respectively). Moreover, a diabetes diagnosis was significantly associated with a high increase in EiA over time (top 10th percentile) even after adjusting for age, BMI, eGFR, METs, self-reported history of heart disease, systolic and diastolic blood pressure; OR=4.4 (1.01-19.3 95% CI) (p=0.049). Finally, elevated fasting blood glucose (>= 100 mg/dl) was the strongest and only significant predictor for a greater increase in EiA over time after adjusting for all five metabolic syndrome components; blood glucose, waist circumference, blood triglycerides, HDL cholesterol, and BP criteria; OR=4.0 (1.6-9.8 95% CI) (p<0.01).Conclusions p id=Par Patients with diabetes and/or elevated fasting blood glucose increase their exercise-induced urinary albumin excretion over time. The ability of EiA to predict major clinical outcomes in patients with and without diabetes needs to be determined in future studies.
C1 [Brzezinski, Rafael Y.; Friedensohn, Limor; Shapira, Itzhak; Zeltser, David; Rogowski, Ori; Berliner, Shlomo; Shenhar-Tsarfaty, Shani] Tel Aviv Sourasky Med Ctr, Dept Internal Med C D&E, 6 Weizmann St, IL-64239 Tel Aviv, Israel.
   [Brzezinski, Rafael Y.; Friedensohn, Limor; Shapira, Itzhak; Zeltser, David; Rogowski, Ori; Berliner, Shlomo; Grupper, Ayelet; Shenhar-Tsarfaty, Shani] Tel Aviv Univ, Sackler Fac Med, Tel Aviv, Israel.
   [Brzezinski, Rafael Y.] Tel Aviv Univ, Sackler Fac Med, Neufled Cardiac Res Inst, Tel Aviv, Israel.
   [Brzezinski, Rafael Y.] Sheba Med Ctr, Tamman Cardiovas Res Inst, Tel Hashomer, Israel.
   [Grupper, Ayelet] Tel Aviv Sourasky Med Ctr, Nephrol Dept, Tel Aviv, Israel.
C3 Tel Aviv University; Sackler Faculty of Medicine; Tel Aviv Sourasky
   Medical Center; Tel Aviv University; Sackler Faculty of Medicine; Tel
   Aviv University; Sackler Faculty of Medicine; Tel Aviv University; Chaim
   Sheba Medical Center; Tel Aviv University; Sackler Faculty of Medicine;
   Tel Aviv Sourasky Medical Center
RP Shenhar-Tsarfaty, S (corresponding author), Tel Aviv Sourasky Med Ctr, Dept Internal Med C D&E, 6 Weizmann St, IL-64239 Tel Aviv, Israel.; Shenhar-Tsarfaty, S (corresponding author), Tel Aviv Univ, Sackler Fac Med, Tel Aviv, Israel.
EM shanis@tlvmc.gov.il
RI Zeltser, David/LYO-6304-2024
OI Grupper, Ayelet/0000-0002-5590-9428; Friedensohn,
   Limor/0000-0003-2454-1015
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NR 33
TC 1
Z9 1
U1 0
U2 0
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1475-2840
J9 CARDIOVASC DIABETOL
JI Cardiovasc. Diabetol.
PD JUN 15
PY 2020
VL 19
IS 1
DI 10.1186/s12933-020-01058-9
PG 8
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism
GA MB5LD
UT WOS:000542643100003
PM 32539802
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Gai, ZB
   Gui, T
   Alecu, I
   Lone, MA
   Hornemann, T
   Chen, QF
   Visentin, M
   Hiller, C
   Hausler, S
   Kullak-Ublick, GA
AF Gai, Zhibo
   Gui, Ting
   Alecu, Irina
   Lone, Museer A.
   Hornemann, Thorsten
   Chen, Qingfa
   Visentin, Michele
   Hiller, Christian
   Hausler, Stephanie
   Kullak-Ublick, Gerd A.
TI Farnesoid X receptor activation induces the degradation of hepatotoxic
   1-deoxysphingolipids in non-alcoholic fatty liver disease
SO LIVER INTERNATIONAL
LA English
DT Article
DE 1-deoxysphingolipid; cytochrome P450; FXR; NAFLD; sphingolipid
ID B-4 OMEGA-HYDROXYLASE; BILE-ACID; OBETICHOLIC ACID; DIFFERENTIAL
   REGULATION; INSULIN-RESISTANCE; CYTOCHROME P4504F; RETINOIC ACID;
   METABOLISM; FXR; ALPHA
AB Background & Aims Patients with non-alcoholic fatty liver disease (NAFLD) exhibit higher levels of plasma 1-deoxysphingolipids than healthy individuals. The aim of this study was to investigate the role of farnesoid X receptor (FXR) in 1-deoxysphingolipid de novo synthesis and degradation. Methods Mice were fed with a high-fat diet (HFD) to induce obesity and NAFLD, and then treated with the FXR ligand obeticholic acid (OCA). Histology and gene expression analysis were performed on liver tissue. Sphingolipid patterns from NAFLD patients and mouse models were assessed by liquid chromatography-mass spectrometry. The molecular mechanism underlying the effect of FXR activation on sphingolipid metabolism was studied in Huh7 cells and primary cultured hepatocytes, as well as in a 1-deoxysphinganine-treated mouse model. Results 1-deoxysphingolipids were increased in both NAFLD patients and mouse models. FXR activation by OCA protected the liver against oxidative stress, apoptosis, and reduced 1-deoxysphingolipid levels, both in a HFD-induced mouse model of obesity and in 1-deoxysphinganine-treated mice. In vitro, FXR activation lowered intracellular 1-deoxysphingolipid levels by inducing Cyp4f-mediated degradation, but not by inhibiting de novo synthesis, thereby protecting hepatocytes against doxSA-induced cytotoxicity, mitochondrial damage, and apoptosis. Overexpression of Cyp4f13 in cells was sufficient to ameliorate doxSA-induced cytotoxicity. Treatment with the Cyp4f pan-inhibitor HET0016 or FXR knock-down fully abolished the protective effect of OCA, indicating that OCA-mediated 1-deoxysphingolipid degradation is FXR and Cyp4f dependent. Conclusions Our study identifies FXR-Cyp4f as a novel regulatory pathway for 1-deoxysphingolipid metabolism. FXR activation represents a promising therapeutic strategy for patients with metabolic syndrome and NAFLD.
C1 [Gai, Zhibo; Gui, Ting] Shandong Univ Tradit Chinese Med, Key Lab Tradit Chinese Med Class Theory, Minist Educ, Jinan 250355, Shandong, Peoples R China.
   [Gai, Zhibo; Visentin, Michele; Hiller, Christian; Hausler, Stephanie; Kullak-Ublick, Gerd A.] Univ Zurich, Univ Hosp Zurich, Dept Clin Pharmacol & Toxicol, Zurich, Switzerland.
   [Alecu, Irina] Ottawa Inst Syst Biol, Neural Regenerat Lab, Dept Biochem Microbiol & Immunol, Ottawa, ON, Canada.
   [Alecu, Irina] uOttawa Brain & Mind Res Inst, Dept Cellular & Mol Med, Ottawa, ON, Canada.
   [Alecu, Irina] Univ Ottawa, Ctr Catalysis & Res Innovat, Dept Chem & Biomol Sci, Ottawa, ON, Canada.
   [Lone, Museer A.; Hornemann, Thorsten] Univ Zurich, Univ Hosp Zurich, Dept Clin Chem, Zurich, Switzerland.
   [Chen, Qingfa] Liaocheng Univ, Inst Tissue Engn & Regenerat Med, Liaocheng Peoples Hosp, Liaocheng, Shandong, Peoples R China.
   [Kullak-Ublick, Gerd A.] Novartis Pharmaceut, Global Drug Dev, CMO & Patient Safety, Mechanist Safety, Basel, Switzerland.
C3 Shandong University of Traditional Chinese Medicine; Ministry of
   Education - China; University of Zurich; University Zurich Hospital;
   University of Ottawa; University of Ottawa; University of Zurich;
   University Zurich Hospital; Liaocheng University; Novartis
RP Gui, T (corresponding author), Shandong Univ Tradit Chinese Med, Key Lab Tradit Chinese Med Class Theory, Minist Educ, Jinan 250355, Shandong, Peoples R China.; Kullak-Ublick, GA (corresponding author), Univ Zurich, Univ Hosp Zurich, Dept Clin Pharmacol & Toxicol, Zurich, Switzerland.
EM stefina1982@gmail.com; gerd.kullak@usz.ch
RI Chen, Qingfa/AAG-1036-2020; GAI, ZHIBO/ABE-7650-2020; Gui,
   Ting/MIP-7941-2025
OI Lone, Museer A./0000-0001-9710-775X; Visentin,
   Michele/0000-0002-0209-5600; Alecu, Irina/0000-0002-7659-9190; Gai,
   Zhibo/0000-0003-1673-6541; Kullak-Ublick, Gerd A./0000-0002-0757-4408
FU Swiss National Science foundation [310030_175639]; National Natural
   Science Foundation of China [81273700]; Swiss National Science
   Foundation (SNF) [310030_175639] Funding Source: Swiss National Science
   Foundation (SNF)
FX This work was supported by the Swiss National Science foundation (Grant
   #310030_175639) to G. A. K.-U and by the National Natural Science
   Foundation of China (no. 81273700).
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NR 64
TC 24
Z9 25
U1 0
U2 30
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1478-3223
EI 1478-3231
J9 LIVER INT
JI Liver Int.
PD APR
PY 2020
VL 40
IS 4
BP 844
EP 859
DI 10.1111/liv.14340
EA JAN 2020
PG 16
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA LA2EY
UT WOS:000506159300001
PM 31883408
DA 2025-06-11
ER

PT J
AU Hotta, Y
   Kataoka, T
   Kimura, K
AF Hotta, Yuji
   Kataoka, Tomoya
   Kimura, Kazunori
TI Testosterone Deficiency and Endothelial Dysfunction: Nitric Oxide,
   Asymmetric Dimethylarginine, and Endothelial Progenitor Cells
SO SEXUAL MEDICINE REVIEWS
LA English
DT Review
DE Testosterone; Endothelial Dysfunction; Nitric Oxide; Inflammation;
   Endothelial Progenitor Cells
ID ARTERIAL ERECTILE DYSFUNCTION; REPLACEMENT THERAPY; ANDROGEN
   REPLACEMENT; METABOLIC SYNDROME; OXIDATIVE STRESS; HYPOGONADAL MEN;
   EXPRESSION; CASTRATION; DIHYDROTESTOSTERONE; IMMUNOPHENOTYPE
AB Introduction: Testosterone deficiency is known to induce endothelial dysfunction, which can lead to erectile dysfunction and/or vascular dysfunction. In some basic and clinical reports, testosterone has been shown to regulate the nitric oxide (NO)/cyclic guanosine monophosphate (cGMP) pathway and thereby influence endothelial function and endothelial progenitor cells (EPCs), which are key for the endothelial repair system.
   Aim: To review the association between testosterone and endothelial dysfunction focusing on NO and EPCs.
   Methods: A review of relevant literature up to September 2018 was performed via PubMed.
   Main Outcome Measures: We reviewed the association between testosterone and endothelial dysfunction focusing on NO derived from endothelial NO synthase, phosphodiesterase type 5 (PDE-5), asymmetric dimethylarginine (ADMA), inflammation, and EPCs.
   Results: Numerous articles describing the association between testosterone deficiency and endothelial dysfunction have been published. Some reports have shown that testosterone deficiency decreases NO production by altering the expression and activity of NO synthase and by regulating ADMA expression. Testosterone also regulates the expression of phosphodiesterase type 5. In addition, some basic and clinical studies have shown that testosterone affects the function and number of EPCs. However, some inconsistencies among these reports have been noted.
   Conclusion: Testosterone deficiency might cause endothelial dysfunction by decreasing NO levels through regulating the expression and activity of NO synthase and increasing ADMA expression. In addition, testosterone might affect the endothelial repair system by regulating the proliferation and migration of EPCs. Testosterone replacement therapy might be useful for treating endothelial dysfunction, considering that some reports have shown that this therapy improved NO bioavailability and EPC function. Copyright (C) 2019, International Society for Sexual Medicine. Published by Elsevier Inc. All rights reserved.
C1 [Hotta, Yuji; Kimura, Kazunori] Nagoya City Univ, Dept Hosp Pharm, Grad Sch Pharmaceut Sci, Nagoya, Aichi, Japan.
   [Kataoka, Tomoya; Kimura, Kazunori] Nagoya City Univ, Grad Sch Med Sci, Dept Clin Pharmaceut, Nagoya, Aichi, Japan.
C3 Nagoya City University; Nagoya City University
RP Kimura, K (corresponding author), 1 Kawasumi,Mizuho Cho,Mizuho Ku, Nagoya, Aichi 4678601, Japan.
EM kkimura@med.nagoya-cu.ac.jp
RI HOTTA, YUJI/ADQ-0667-2022; Kataoka, Tomoya/HTM-3619-2023
OI HOTTA, Yuji/0000-0002-9474-7775; Kataoka, Tomoya/0000-0001-9683-4680
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NR 70
TC 53
Z9 57
U1 1
U2 10
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2050-0513
EI 2050-0521
J9 SEX MED REV
JI Sex. Med. Rev.
PD OCT
PY 2019
VL 7
IS 4
BP 661
EP 668
DI 10.1016/j.sxmr.2019.02.005
PG 8
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA KE9BS
UT WOS:000508844900013
PM 30987932
DA 2025-06-11
ER

PT J
AU Muggeo, P
   Muggeo, VMR
   Giordano, P
   Delvecchio, M
   Altomare, M
   Novielli, C
   Ciccone, MM
   D'Amato, G
   Faienza, MF
   Santoro, N
AF Muggeo, Paola
   Muggeo, Vito Michele Rosario
   Giordano, Paola
   Delvecchio, Maurizio
   Altomare, Maria
   Novielli, Chiara
   Ciccone, Marco Matteo
   D'Amato, Gabriele
   Faienza, Maria Felicia
   Santoro, Nicola
TI Cardiovascular dysfunction and vitamin D status in childhood acute
   lymphoblastic leukemia survivors
SO WORLD JOURNAL OF PEDIATRICS
LA English
DT Article
DE Acute lymphoblastic leukemia; Cardiovascular disease; C-IMT; Vascular
   ultrasound studies; Vitamin D
ID METABOLIC SYNDROME; OXIDATIVE STRESS; RISK-FACTORS; D DEFICIENCY; D
   INSUFFICIENCY; OBESE CHILDREN; ENDOTHELIN-1; ATHEROSCLEROSIS;
   ASSOCIATION; PREVALENCE
AB Background Vitamin D (25-OHD) has a role in bone health after treatment for cancer. 25-OHD deficiency has been associated with risk factors for cardiovascular disease, but no data focusing on this topic in childhood cancer survivors have been published. We investigated the 25-OHD status in children treated for acute lymphoblastic leukemia (ALL), and evaluated its influence on vascular function. Methods 25-OHD levels were evaluated in 52 ALL survivors and 40 matched healthy controls. Patients were grouped according to 25-OHD level (< 20 ng/m or >= 20 ng/ml). Auxological parameters, biochemical and hemostatic markers of endothelial function (AD, HMW-AD, ET-1, vWFAg, TAT, D-dimers, Fbg, and hs-CRP), ultrasound markers of vascular endothelial function (flow-mediated dilatation, FMD, common carotid intima-media thickness, C-IMT, and antero-posterior diameter of infra-renal abdominal aorta, APAO) were evaluated in the patients. Results Cases showed higher prevalence of 25-OHD deficiency than controls (p = 0.002). In univariate analysis via mean comparisons, 25-OHD deficient (< 20 ng/ml) patients showed higher C-IMT values compared to the 25-OHD non-deficient (>= 20 ng/ml) group (P = 0.023). Significant differences were also found for ET-1 (P = 0.035) and AD-HMW (P = 0.015). In the multiple regression models controlling for some confounders, 25-OHD still was associated with C-IMT (P = 0.0163), ET-1 (P = 0.0077), and AD-HMW (P = 0.0008). Conclusions Childhood ALL survivors show higher prevalence of 25-OHD deficiency as compared to controls. The 25-OHD levels appear to be linked to indicators of endothelial and vascular dysfunction. Careful monitoring of 25-OHD balance may help to prevent cardiovascular diseases in childhood ALL survivors, characterized by high cardiovascular risk.
C1 [Muggeo, Paola; Novielli, Chiara; Santoro, Nicola] Univ Hosp Policlin, Dept Pediat Oncol & Hematol, Piazza G Cesare 11, I-70124 Bari, Italy.
   [Muggeo, Vito Michele Rosario] Univ Palermo, Dept Econ Business & Stat Sci, Palermo, Italy.
   [Giordano, Paola; Altomare, Maria; Faienza, Maria Felicia] Univ A Moro, Pediat Sect, Dept Biomed & Human Oncol, Bari, Italy.
   [Delvecchio, Maurizio] ASL Matera, Madonna delle Grazie Hosp, Mother & Children Hlth Care Dept, Pediat & Neonatol Unit, Matera, Italy.
   [Ciccone, Marco Matteo] Univ A Moro, Cardiovasc Dis Sect, Dept Emergency & Organ Transplantat, Bari, Italy.
   [D'Amato, Gabriele] Di Venere Hosp, Neonatal Intens Care Unit, Bari, Italy.
C3 Universita degli Studi di Bari Aldo Moro; University of Palermo;
   Universita degli Studi di Bari Aldo Moro; Universita degli Studi di Bari
   Aldo Moro
RP Muggeo, P (corresponding author), Univ Hosp Policlin, Dept Pediat Oncol & Hematol, Piazza G Cesare 11, I-70124 Bari, Italy.
EM paola.muggeo@tiscali.it
RI Ciccone, Marco/C-5271-2013; Faienza, Maria/K-6779-2016; Muggeo,
   Vito/P-4864-2015; Delvecchio, Maurizio/K-8762-2012; Muggeo,
   Paola/ACF-7052-2022
OI D'Amato, Gabriele/0000-0001-5160-9340; Muggeo, Vito/0000-0002-3386-4054;
   Delvecchio, Maurizio/0000-0002-1528-0012; Muggeo,
   Paola/0000-0001-8813-3200
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NR 37
TC 9
Z9 9
U1 0
U2 3
PU ZHEJIANG UNIV SCH MEDICINE
PI HANGZHOU
PA CHILDRENS HOSPITAL, 57 ZHUGAN XIANG, HANGZHOU, 310003, PEOPLES R CHINA
SN 1708-8569
EI 1867-0687
J9 WORLD J PEDIATR
JI World Journal of Pediatrics
PD OCT
PY 2019
VL 15
IS 5
BP 465
EP 470
DI 10.1007/s12519-019-00258-y
PG 6
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA JC5EL
UT WOS:000489302900006
PM 31055782
DA 2025-06-11
ER

PT J
AU Raffaele, M
   Bellner, L
   Singh, SP
   Favero, G
   Rezzani, R
   Rodella, LF
   Falck, JR
   Abraham, NG
   Vanella, L
AF Raffaele, Marco
   Bellner, Lars
   Singh, Shailendra P.
   Favero, Gaia
   Rezzani, Rita
   Rodella, Luigi Fabrizio
   Falck, John R.
   Abraham, Nader G.
   Vanella, Luca
TI Epoxyeicosatrienoic intervention improves NAFLD in leptin receptor
   deficient mice by an increase in PGC1α-HO-1-PGC1α-mitochondrial
   signaling
SO EXPERIMENTAL CELL RESEARCH
LA English
DT Article
DE CYP-450 epoxygenase; Insulin sensitivity; Non-alcoholic fatty liver
   disease (NAFLD); FGF21; SIRT1
ID SOLUBLE EPOXIDE HYDROLASE; FATTY LIVER-DISEASE; LIPID-PEROXIDATION;
   METABOLIC SYNDROME; HO-1 EXPRESSION; HEME; PGC-1-ALPHA; OBESITY;
   STEATOHEPATITIS; ACIDS
AB Background: Non-alcoholic fatty liver disease (NAFLD) is associated with obesity and is considered to be an inflammatory disorder characterized by fatty acid accumulation, oxidative stress, and lipotoxicity. We have previously reported that epoxyeicosatrienoic acid-agonist (EET-A) has multiple beneficial effects on cardiac, renal and adipose tissue function while exhibiting both anti-inflammatory and anti-oxidant activities. We hypothesized that EET-A intervention would play a central role in attenuation of obesity-induced steatosis and hepatic fibrosis that leads to NAFLD.
   Methods: We studied the effect of EET-A on fatty liver using db/db mice as a model of obesity. Mice were fed a high fat diet (HFD) for 16 weeks and administered EET-A twice weekly for the final 8 weeks.
   Results: db/db mice fed HFD significantly increased hepatic lipid accumulation as manifested by increases in NAS scores, hepatic fibrosis, insulin resistance, and inflammation, and decreases in mitochondrial mitofusin proteins (Mfn 1/2) and anti-obesity genes Fibroblast growth factor 21 (FGF21) and Cellular Repressor of E1A-Stimulated Genes 1 (CREG1). EET-A administration reversed the decrease in these genes and reduced liver fibrosis. Knockout of Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1 alpha) in EET-A treated mice resulted in a reversal of the beneficial effects of EET-A administration.
   Conclusions: EET-A intervention diminishes fatty acid accumulation, fibrosis, and NFALD associated with an increase in HO-1-PGC1 alpha and increased insulin receptor phosphorylation. A pharmacological strategy involving EETs may offer a potential therapeutic approach in preventing fibrosis, mitochondrial dysfunction, and the development of NAFLD.
C1 [Raffaele, Marco; Abraham, Nader G.] New York Med Coll, Dept Med, Valhalla, NY 10595 USA.
   [Bellner, Lars; Singh, Shailendra P.; Abraham, Nader G.] New York Med Coll, Dept Pharmacol, Valhalla, NY 10595 USA.
   [Raffaele, Marco; Vanella, Luca] Univ Catania, Dept Drug Sci, Catania, Italy.
   [Rezzani, Rita; Rodella, Luigi Fabrizio] Univ Brescia, Dept Clin & Expt Sci, Anat & Physiopathol Div, Brescia, Italy.
   [Favero, Gaia; Rezzani, Rita; Rodella, Luigi Fabrizio] Univ Brescia, Interdept Univ Ctr Res Adqot & Regenerat Tissues, Brescia, Italy.
   [Falck, John R.] Univ Southwestern Med Ctr, Dept Biochem, Dallas, TX 75390 USA.
   [Raffaele, Marco] Univ Catania, Sicily, Italy.
C3 New York Medical College; New York Medical College; University of
   Catania; University of Brescia; University of Brescia; University of
   Catania
RP Vanella, L (corresponding author), Univ Catania, Dept Drug Sci, Catania, Italy.
EM lvanella@unict.it
RI Raffaele, Marco/AAQ-2895-2020; Falck, John/B-3030-2011; Vanella,
   Luca/J-7354-2016; SINGH, SHAILENDRA PRATAP/R-8524-2018
OI SINGH, SHAILENDRA PRATAP/0000-0003-2996-0374
FU National Institutes of Health [HL139561]
FX This work was supported by the National Institutes of Health (Grant
   HL139561; NGA). All authors have read the manuscript and agree entirely
   with its contents. We thank Mrs. Jennifer Brown for her editorial
   assistance in preparing the manuscript. The content is solely the
   responsibility of the authors and does not necessarily represent the
   official views of the National Institutes of Health.
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NR 37
TC 39
Z9 43
U1 0
U2 30
PU ELSEVIER INC
PI SAN DIEGO
PA 525 B STREET, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0014-4827
EI 1090-2422
J9 EXP CELL RES
JI Exp. Cell Res.
PD JUL 15
PY 2019
VL 380
IS 2
BP 180
EP 187
DI 10.1016/j.yexcr.2019.04.029
PG 8
WC Oncology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Cell Biology
GA IA1GP
UT WOS:000469307600008
PM 31039348
DA 2025-06-11
ER

PT J
AU Hong, SM
   Woo, HW
   Kim, MK
   Kim, SY
   Lee, YH
   Shin, DH
   Shin, MH
   Chun, BY
   Choi, BY
AF Hong, Sang M.
   Woo, Hey W.
   Kim, Mi K.
   Kim, Se Y.
   Lee, Young-Hoon
   Shin, Dong H.
   Shin, Min-Ho
   Chun, Byung-Yeol
   Choi, Bo Y.
TI A prospective association between dietary folate intake and type 2
   diabetes risk among Korean adults aged 40 years or older: the Korean
   Multi-Rural Communities Cohort (MRCohort) Study
SO BRITISH JOURNAL OF NUTRITION
LA English
DT Article
DE Dietary folate intakes; Type 2 diabetes; Prospective cohort studies;
   Korea
ID FOLIC-ACID SUPPLEMENTATION; CORONARY-HEART-DISEASE; HOMOCYSTEINE
   CONCENTRATIONS; CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; OXIDATIVE
   STRESS; LIFE-STYLE; B-VITAMINS; METAANALYSIS; DYSFUNCTION
AB It has not been well established whether dietary folate intake reduces the risk of diabetes development. We aimed to clarify the prospective association between dietary folate intake and type 2 diabetes (T2D) risk among 7333 Korean adults aged 40 years or older who were included in the Multi-Rural Communities Cohort. Dietary folate intake was estimated from all 106 food items listed on a FFQ, not including folate intake from supplements. Two different measurements of dietary folate intake were used: the baseline consumption and the average consumption from baseline until just before the end of follow-up. The association between folate intake and T2D risk was determined through a modified Poisson regression model with a robust error estimator controlling for potential confounders. For 29 745 person years, 319 cases of diabetes were ascertained. In multivariable analyses, dietary folate intake was inversely associated with risk of T2D for women, not for men. For women, the incidence rate ratio of diabetes in the third tertile compared with the first tertile was 0.57 (95 % CI 0.38-0.87, P-for trend=0.0085) in the baseline consumption model and 0.64 (95 % CI 0.43-0.95, P-for trend=0.0244) in the average consumption model. These inverse associations was found in both normal fasting blood glucose group and impaired fasting glucose group among women. Among non-users of multinutrients and vitamin supplements, the significant inverse association remained. Thus, higher dietary intake of folate is prospectively associated with lower risk of diabetes for women.
C1 [Hong, Sang M.] Hallym Univ, Dongtan Sacred Heart Hosp 7, Dept Internal Med, Div Endocrinol, Hwaseong Si 18450, Gyeonggi Do, South Korea.
   [Woo, Hey W.; Kim, Mi K.; Kim, Se Y.; Choi, Bo Y.] Hanyang Univ, Dept Prevent Med, Coll Med, Seoul 04763, South Korea.
   [Woo, Hey W.; Kim, Mi K.; Kim, Se Y.; Choi, Bo Y.] Hanyang Univ, Inst Hlth & Soc, Seoul 04763, South Korea.
   [Lee, Young-Hoon] Wonkwang Univ, Coll Med, Dept Prevent Med, Iksan 54538, South Korea.
   [Lee, Young-Hoon] Wonkwang Univ, Coll Med, Inst Wonkwang Med Sci, Iksan 54538, South Korea.
   [Shin, Dong H.] Keimyung Univ, Dept Occupat & Environm Med, Dongsan Med Ctr, Daegu 42403, South Korea.
   [Shin, Min-Ho] Chonnam Natl Univ, Dept Prevent Med, Med Sch, Gwangju 61186, South Korea.
   [Chun, Byung-Yeol] Kyungpook Natl Univ, Sch Med, Dept Prevent Med, Daegu 41566, South Korea.
   [Chun, Byung-Yeol] Kyungpook Natl Univ, Hlth Promot Res Ctr, Daegu 41566, South Korea.
C3 Hallym University; Hanyang University; Hanyang University; Wonkwang
   University; Wonkwang University; Keimyung University; Chonnam National
   University; Kyungpook National University (KNU); Kyungpook National
   University (KNU)
RP Kim, MK (corresponding author), Hanyang Univ, Dept Prevent Med, Coll Med, Seoul 04763, South Korea.; Kim, MK (corresponding author), Hanyang Univ, Inst Hlth & Soc, Seoul 04763, South Korea.
EM kmkkim@hanyang.ac.kr
RI Kim, Mi-Kyung/E-8682-2012; Hong, Sangmo/C-9515-2018; Woo,
   HyeWon/LMO-9223-2024
OI Woo, Hye Won/0000-0001-6072-6119; Kim, Mi Kyung/0000-0001-8503-2631;
   Hong, Sangmo/0000-0002-8535-0565
FU Korea Centers for Disease Control and Prevention [2004-E71004-00,
   2005-E71011-00, 2006-E71009-00, 2007-E71002-00, 2008-E71004-00,
   2009-E71006-00, 2010-E71003-00, 2011-E71002-00, 2012-E71007-00,
   2013-E71008-00]; National Research Foundation of Korea - Korea
   government (Ministry of Science, ICT & Future Planning)
   [2016R1A2B2011352]
FX This work was supported by the Research Program funded by the Korea
   Centers for Disease Control and Prevention (2004-E71004-00,
   2005-E71011-00, 2006-E71009-00, 2007-E71002-00, 2008-E71004-00,
   2009-E71006-00, 2010-E71003-00, 2011-E71002-00, 2012-E71007-00,
   2013-E71008-00) and was supported by the National Research Foundation of
   Korea grant funded by the Korea government (Ministry of Science, ICT &
   Future Planning) (no. 2016R1A2B2011352).
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NR 47
TC 23
Z9 24
U1 0
U2 15
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1145
EI 1475-2662
J9 BRIT J NUTR
JI Br. J. Nutr.
PD DEC 28
PY 2017
VL 118
IS 12
BP 1078
EP 1088
DI 10.1017/S0007114517003087
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA FQ4MF
UT WOS:000418330900009
PM 29198189
OA Bronze
DA 2025-06-11
ER

PT J
AU Nunez-Durán, E
   Chanclón, B
   Sütt, S
   Real, J
   Marschall, HU
   Asterholm, IW
   Cansby, E
   Mahlapuu, M
AF Nunez-Duran, Esther
   Chanclon, Belen
   Sutt, Silva
   Real, Joana
   Marschall, Hanns-Ulrich
   Asterholm, Ingrid Wernstedt
   Cansby, Emmelie
   Mahlapuu, Margit
TI Protein kinase STK25 aggravates the severity of non-alcoholic fatty
   pancreas disease in mice
SO JOURNAL OF ENDOCRINOLOGY
LA English
DT Article
DE non-alcoholic fatty pancreas disease; ectopic lipid storage; beta-cell
   dysfunction
ID ENDOPLASMIC-RETICULUM STRESS; BETA-CELL DYSFUNCTION; INSULIN-RESISTANCE;
   METABOLIC SYNDROME; TCA CYCLE; APOPTOSIS; DEFECTS; FAILURE;
   GLUCOLIPOTOXICITY; MACROPHAGES
AB Characterising the molecular networks that negatively regulate pancreatic beta-cell function is essential for understanding the underlying pathogenesis and developing new treatment strategies for type 2 diabetes. We recently identified serine/threonine protein kinase 25 (STK25) as a critical regulator of ectopic fat storage, meta-inflammation, and fibrosis in liver and skeletal muscle. Here, we assessed the role of STK25 in control of progression of non-alcoholic fatty pancreas disease in the context of chronic exposure to dietary lipids in mice. We found that overexpression of STK25 in high-fat-fed transgenic mice aggravated diet-induced lipid storage in the pancreas compared with that of wild-type controls, which was accompanied by exacerbated pancreatic inflammatory cell infiltration, stellate cell activation, fibrosis and apoptosis. Pancreas of Stk25 transgenic mice also displayed a marked decrease in islet beta/alpha-cell ratio and alteration in the islet architecture with an increased presence of a-cells within the islet core, whereas islet size remained similar between genotypes. After a continued challenge with a high-fat diet, lower levels of fasting plasma insulin and C-peptide, and higher levels of plasma leptin, were detected in Stk25 transgenic vs wild-type mice. Furthermore, the glucose-stimulated insulin secretion was impaired in high-fat-fed Stk25 transgenic mice during glucose tolerance test, in spite of higher net change in blood glucose concentrations compared with wild-type controls, suggesting islet beta-cell dysfunction. In summary, this study unravels a role for STK25 in determining the susceptibility to diet-induced nonalcoholic fatty pancreas disease in mice in connection to obesity. Our findings highlight STK25 as a potential drug target for metabolic disease.
C1 [Nunez-Duran, Esther; Chanclon, Belen; Sutt, Silva; Cansby, Emmelie; Mahlapuu, Margit] Univ Gothenburg, Sahlgrenska Univ Hosp, Inst Med, Dept Mol & Clin Med,Lundberg Lab Diabet Res, Gothenburg, Sweden.
   [Chanclon, Belen; Real, Joana; Asterholm, Ingrid Wernstedt] Univ Gothenburg, Inst Neurosci & Physiol, Dept Metab Physiol, Gothenburg, Sweden.
   [Marschall, Hanns-Ulrich] Univ Gothenburg, Sahlgrenska Univ Hosp, Inst Med, Dept Mol & Clin Med,Wallenberg Lab, Gothenburg, Sweden.
C3 University of Gothenburg; Sahlgrenska University Hospital; University of
   Gothenburg; Sahlgrenska University Hospital; University of Gothenburg
RP Mahlapuu, M (corresponding author), Univ Gothenburg, Sahlgrenska Univ Hosp, Inst Med, Dept Mol & Clin Med,Lundberg Lab Diabet Res, Gothenburg, Sweden.
EM Margit.Mahlapuu@gu.se
RI Wernstedt Asterholm, Ingrid/JCE-0785-2023; Mahlapuu,
   Margit/MVU-2841-2025; Marschall, Hanns-Ulrich/K-8842-2017; Real, Joana
   I./I-6715-2016
OI Chanclon Garcia, Belen/0000-0001-7170-9699; Mahlapuu,
   Margit/0000-0001-8740-8874; Wernstedt Asterholm,
   Ingrid/0000-0002-0755-5784; Real, Joana I./0000-0003-0209-2378;
   Marschall, Hanns-Ulrich/0000-0001-7347-3085
FU Swedish Research Council; Novo Nordisk Foundation; Swedish Heart and
   Lung Foundation; Diabetes Wellness Network Sweden; Estonian Research
   Council; Swedish Diabetes Foundation; Royal Society of Arts and Sciences
   in Gothenburg; M Bergvalls Foundation; Wiberg Foundation; Adlerbert
   Research Foundation; I Hultman Foundation; S and E Goljes Foundation;
   West Sweden ALF Program; F Neubergh Foundation; I-B and A Lundbergs
   Research Foundation; European Foundation
FX This work was supported by grants from the Swedish Research Council, the
   Novo Nordisk Foundation, the Swedish Heart and Lung Foundation, the
   Diabetes Wellness Network Sweden, the Estonian Research Council, the
   Swedish Diabetes Foundation, the Royal Society of Arts and Sciences in
   Gothenburg, the M Bergvalls Foundation, the Wiberg Foundation, the
   Adlerbert Research Foundation, the I Hultman Foundation, the S and E
   Goljes Foundation, the West Sweden ALF Program, the F Neubergh
   Foundation, the I-B and A Lundbergs Research Foundation, and the
   European Foundation for the Study of Diabetes and Novo Nordisk
   Partnership for Diabetes Research in Europe.
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NR 51
TC 23
Z9 24
U1 0
U2 6
PU BIOSCIENTIFICA LTD
PI BRISTOL
PA STARLING HOUSE, 1600 BRISTOL PARKWAY N, BRISTOL, ENGLAND
SN 0022-0795
EI 1479-6805
J9 J ENDOCRINOL
JI J. Endocrinol.
PD JUL
PY 2017
VL 234
IS 1
BP 15
EP 27
DI 10.1530/JOE-17-0018
PG 13
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA EZ8MO
UT WOS:000404980300019
PM 28442507
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Liang, WY
   Liu, WW
   Liu, ML
   Xiang, W
   Feng, XR
   Huang, B
   Chen, XH
   Sun, YS
AF Liang, W. Y.
   Liu, W. W.
   Liu, M. L.
   Xiang, W.
   Feng, X. R.
   Huang, B.
   Chen, X. H.
   Sun, Y. S.
TI Serum uric acid level and left ventricular hypertrophy in elderly male
   patients with nonvalvular atrial fibrillation
SO NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
LA English
DT Article
DE Serum uric acid; Left ventricular hypertrophy; Atrial fibrillation
ID CARDIOVASCULAR RISK; METABOLIC SYNDROME; DISEASE; HYPERURICEMIA;
   ASSOCIATION; POPULATION; HYPERTENSION; MORTALITY; SYSTEM; WOMEN
AB Background and aims: Recent studies have suggested that serum uric acid (SUA) induces oxidative stress and inflammation, which are involved in the mechanism of cardiac hypertrophy. In patients with atrial fibrillation (AF), comorbidity of left ventricular hypertrophy (LVH) exacerbates cardiac function. In this study, we investigated the association between SUA and cardiac hypertrophy in AF patients.
   Methods and results: Initially, 1296 consecutive elderly patients (age >60) with nonvalvular AF were retrospectively selected from the inpatient clinic between January 2012 and April 2015. Demographic, clinical, and echocardiographic characteristics were carefully recorded. The final study population was 577 patients. The mean SUA level was significantly higher in patients with LVH than those without LVH. Compared with the non-LVH group, the LVH group was older, had a higher percentage of female patients, and had lower hemoglobin levels and estimated glomerular filtration rates. Patients in the LVH group also had a higher rate of coronary heart disease and fewer had history of radiofrequency ablation compared with the non-LVH group. In the hyperuricemia group, B-type natriuretic peptide levels, left atrial diameter, left ventricular mass index, and percentage of NYHA (New York Heart Association) class III/IV were significantly higher than the SUA normal group. Multivariate logistic regression analysis indicated the independent risk factors for LVH in elderly AF patients included SUA, age, male sex, the presence of coronary heart disease, and diuretic therapy. Subgroup analysis identified SUA as a significant risk factor associated with LVH in men.
   Conclusions: SUA was independently associated with LVH in elderly male patients with nonvalvular AF. (C) 2016 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.
C1 [Liang, W. Y.; Liu, W. W.; Liu, M. L.; Xiang, W.; Feng, X. R.; Huang, B.; Chen, X. H.; Sun, Y. S.] Peking Univ First Hosp, Dept Geriatr, 8 Xishiku St, Beijing 100034, Peoples R China.
C3 Peking University
RP Liu, ML (corresponding author), Peking Univ First Hosp, Dept Geriatr, 8 Xishiku St, Beijing 100034, Peoples R China.
EM meilinliu@yahoo.com
FU National Science and Technology Support Program [2012BAI37B05]
FX This study was supported by the National Science and Technology Support
   Program, whose topic is Translational Medicine Research of Treatment
   Risk and Strategy in the Old Population (2012BAI37B05). The funding
   agency did not play any role in the collection, analysis, and
   interpretation of data or the preparation of the manuscript.
CR Carabello BA, 2002, J CARD FAIL, V8, pS258, DOI 10.1054/jcaf.2002.129250
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NR 24
TC 16
Z9 17
U1 0
U2 11
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0939-4753
EI 1590-3729
J9 NUTR METAB CARDIOVAS
JI Nutr. Metab. Carbiovasc. Dis.
PD JUL
PY 2016
VL 26
IS 7
BP 575
EP 580
DI 10.1016/j.numecd.2016.03.011
PG 6
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism; Nutrition
   & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism;
   Nutrition & Dietetics
GA DN8XG
UT WOS:000377362600003
PM 27162100
DA 2025-06-11
ER

PT J
AU Weiss, B
   Krauthammer, A
   Soudack, M
   Lahad, A
   Sarouk, I
   Somech, R
   Heimer, G
   Ben-Zeev, B
   Nissenkorn, A
AF Weiss, Batia
   Krauthammer, Alexander
   Soudack, Michalle
   Lahad, Avishay
   Sarouk, Ifat
   Somech, Raz
   Heimer, Gali
   Ben-Zeev, Bruria
   Nissenkorn, Andreea
TI Liver Disease in Pediatric Patients With Ataxia Telangiectasia: A Novel
   Report
SO JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
LA English
DT Article
DE metabolic syndrome; hepatic steatosis; dyslipidemia; fatty liver; ATM
ID OXIDATIVE STRESS; NONALCOHOLIC STEATOHEPATITIS; NATURAL-HISTORY; ATM
   PROTEIN; MOUSE MODEL; FIBROSIS; KINASE; QUANTIFICATION; ULTRASOUND;
   STEATOSIS
AB Objective:
   Ataxia telangiectasia (A-T) is a rare genetic multiorgan disease. Although gastrointestinal involvement is known, hepatic involvement in A-T has not been investigated. We aimed to study the hepatic involvement in a large cohort of patients with A-T.
   Methods:
   A retrospective review of patients, studied from January 1986 to January 2015 at a National A-T Center. Clinical data including demographic, genetic, laboratory, nutritional, radiographic, and histological data were retrieved.
   Results:
   Fifty-three patients, 27 (49%) boys, age 14.6 +/- 5.2 years (range 5.9-26.1 years), were included. Twenty-three patients (43.4%), age 9.9 +/- 5.1 years, had consistently abnormal liver enzymes. The mean enzyme levels were alanine aminotransferase 76.8 +/- 73.8 IU/L, aspartate aminotransferase 70 +/- 50 IU/L, alkaline phosphatase 331 +/- 134 IU/L, and gamma glutamyl transferase 114.7 +/- 8 IU/L. Evaluation of other etiology of liver disease was negative. Ultrasonography revealed fatty liver in 9 of them (39%). Liver biopsy was performed in 2 patients, revealing mild-to-moderate steatosis in both, and fibrosis in 1 patient. Progression to advanced liver disease occurred in 2 of 23 (9%) patients within 2 to 5 years. Dyslipidemia was significantly associated with abnormal liver enzymes: 3 of 30 (10%) patients without abnormal liver enzymes versus 10 of 23 (45.5%) patients with abnormal liver enzymes, respectively (P < 0.05, Fisher exact test). No correlation was found between hepatic involvement and HbA1C, sex, presence of malignancy, or type of mutation.
   Conclusions:
   Abnormal liver enzymes and fatty liver are common in patients with A-T and may progress to advanced liver disease at a young age. These findings are novel and implicate that patients with A-T with abnormal liver enzymes should be evaluated for the presence of liver disease.
C1 [Weiss, Batia; Lahad, Avishay] Tel Aviv Univ, Edmond & Lily Safra Childrens Hosp, Pediat Gastroenterol & Nutr Unit, Tel Hashomer, Israel.
   [Krauthammer, Alexander; Somech, Raz] Tel Aviv Univ, Edmond & Lily Safra Childrens Hosp, Dept Pediat & Pediat Immunol, Tel Hashomer, Israel.
   [Soudack, Michalle] Tel Aviv Univ, Edmond & Lily Safra Childrens Hosp, Pediat Radiol Unit, Tel Hashomer, Israel.
   [Sarouk, Ifat] Tel Aviv Univ, Edmond & Lily Safra Childrens Hosp, Pediat Pulmonol Unit, Tel Hashomer, Israel.
   [Sarouk, Ifat] Tel Aviv Univ, Edmond & Lily Safra Childrens Hosp, Ataxia Telangiectasia Ctr, Tel Hashomer, Israel.
   [Heimer, Gali; Ben-Zeev, Bruria; Nissenkorn, Andreea] Tel Aviv Univ, Edmond & Lily Safra Childrens Hosp, Pediat Neurol Unit, Tel Hashomer, Israel.
C3 Tel Aviv University; Tel Aviv University; Tel Aviv University; Tel Aviv
   University; Tel Aviv University; Tel Aviv University
RP Weiss, B (corresponding author), Edmond & Lily Safra Childrens Hosp, Pediat Gastroenterol & Nutr Unit, IL-52625 Tel Hashomer, Israel.
EM weissb@sheba.health.gov.il
RI Krauthammer, Alex/AAB-5869-2021
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NR 35
TC 27
Z9 27
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0277-2116
EI 1536-4801
J9 J PEDIATR GASTR NUTR
JI J. Pediatr. Gastroenterol. Nutr.
PD APR
PY 2016
VL 62
IS 4
BP 550
EP 555
DI 10.1097/MPG.0000000000001036
PG 6
WC Gastroenterology & Hepatology; Nutrition & Dietetics; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Nutrition & Dietetics; Pediatrics
GA DI0TK
UT WOS:000373209900009
PM 26594831
DA 2025-06-11
ER

PT J
AU Lula, ECO
   Ribeiro, CCC
   Hugo, FN
   Alves, CMC
   Silva, AAM
AF Lula, Estevam C. O.
   Ribeiro, Cecilia C. C.
   Hugo, Fernando N.
   Alves, Claudia M. C.
   Silva, Antonio A. M.
TI Added sugars and periodontal disease in young adults: an analysis of
   NHANES III data
SO AMERICAN JOURNAL OF CLINICAL NUTRITION
LA English
DT Article
ID NUTRITION EXAMINATION SURVEY; 3RD NATIONAL-HEALTH; SYSTEMIC
   INFLAMMATION; METABOLIC SYNDROME; OXIDATIVE STRESS; GLYCEMIC CONTROL;
   ASSOCIATION; FRUCTOSE; GLUCOSE; SUCROSE
AB Background: Added sugar consumption seems to trigger a hyper-inflammatory state and may result in visceral adiposity, dyslipidemia, and insulin resistance. These conditions are risk factors for periodontal disease. However, the role of sugar intake in the cause of periodontal disease has not been adequately studied.
   Objective: We evaluated the association between the frequency of added sugar consumption and periodontal disease in young adults by using NHANES III data.
   Design: Data from 2437 young adults (aged 18-25 y) who participated in NHANES III (1988-1994) were analyzed. We estimated the frequency of added sugar consumption by using food-frequency questionnaire responses. We considered periodontal disease to be present in teeth with bleeding on probing and a probing depth mm at one or more sites. We evaluated this outcome as a discrete variable in Poisson regression models and as a categorical variable in multinomial logistic regression models adjusted for sex, age, race-ethnicity, education, poverty-income ratio, tobacco exposure, previous diagnosis of diabetes, and body mass index.
   Results: A high consumption of added sugars was associated with a greater prevalence of periodontal disease in middle [prevalence ratio (PR): 1.39; 95% CI: 1.02, 1.89] and upper (PR: 1.42; 95% CI: 1.08, 1.85) tertiles of consumption in the adjusted Poisson regression model. The upper tertile of added sugar intake was associated with periodontal disease in teeth (PR: 1.73; 95% CI: 1.19, 2.52) but not with periodontal disease in only one tooth (PR: 0.85; 95% Cl: 0.54, 1.34) in the adjusted multinomial logistic regression model.
   Conclusion: A high frequency of consumption of added sugars is associated with periodontal disease, independent of traditional risk factors, suggesting that this consumption pattern may contribute to the systemic inflammation observed in periodontal, disease and associated noncommunicable diseases.
C1 [Lula, Estevam C. O.; Silva, Antonio A. M.] Univ Fed Maranhao, Dept Publ Hlth, BR-65085580 Sao Luis, MA, Brazil.
   [Ribeiro, Cecilia C. C.; Alves, Claudia M. C.] Univ Fed Maranhao, Dept Dent, BR-65085580 Sao Luis, MA, Brazil.
   [Hugo, Fernando N.] Univ Fed Rio Grande do Sul, Dept Prevent & Social Dent, Porto Alegre, RS, Brazil.
C3 Universidade Federal do Maranhao; Universidade Federal do Maranhao;
   Universidade Federal do Rio Grande do Sul
RP Ribeiro, CCC (corresponding author), Univ Fed Maranhao, Ctr Ciencias Saude, Dept Odontol 2, Campus Bacanga, BR-65085580 Sao Luis, MA, Brazil.
EM cecilia_ribeiro@hotmail.com
RI Alves, Cláudia/H-2194-2016; Hugo, Fernando/H-6789-2019; Silva,
   Antonio/B-5410-2009; Ribeiro, Cecilia Claudia Costa/H-2198-2016
OI Lula, Estevam Carlos de Oliveira/0000-0002-2063-4161; Neves Hugo,
   Fernando/0000-0003-2222-7719; Silva, Antonio/0000-0003-4968-5138;
   Ribeiro, Cecilia Claudia Costa/0000-0003-0041-7618; Alves,
   Claudia/0000-0003-4705-4914
FU Fundacao de Amparo a Pesquisa e ao Desenvolvimento Cientifico e
   Tecnologico do Maranhao [PAEDT 01342/12]
FX Supported by the Fundacao de Amparo a Pesquisa e ao Desenvolvimento
   Cientifico e Tecnologico do Maranhao (grant PAEDT 01342/12).
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NR 38
TC 79
Z9 85
U1 1
U2 17
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0002-9165
EI 1938-3207
J9 AM J CLIN NUTR
JI Am. J. Clin. Nutr.
PD OCT
PY 2014
VL 100
IS 4
BP 1182
EP 1187
DI 10.3945/ajcn.114.089656
PG 6
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA AP7OT
UT WOS:000342267300026
PM 25240081
OA Bronze
DA 2025-06-11
ER

PT J
AU Gkourogianni, A
   Kosteria, I
   Telonis, AG
   Margeli, A
   Mantzou, E
   Konsta, M
   Loutradis, D
   Mastorakos, G
   Papassotiriou, I
   Klapa, MI
   Kanaka-Gantenbein, C
   Chrousos, GP
AF Gkourogianni, Alexandra
   Kosteria, Ioanna
   Telonis, Aristeidis G.
   Margeli, Alexandra
   Mantzou, Emilia
   Konsta, Maria
   Loutradis, Dimitrios
   Mastorakos, George
   Papassotiriou, Ioannis
   Klapa, Maria I.
   Kanaka-Gantenbein, Christina
   Chrousos, George P.
TI Plasma Metabolomic Profiling Suggests Early Indications for
   Predisposition to Latent Insulin Resistance in Children Conceived by
   ICSI
SO PLOS ONE
LA English
DT Article
ID PITUITARY-ADRENAL AXIS; ASSISTED REPRODUCTIVE TECHNOLOGY;
   INTRACYTOPLASMIC SPERM INJECTION; IN-VITRO FERTILIZATION; PSYCHOSOCIAL
   STRESS; BORN; OBESITY; TISSUE; NEUROENDOCRINE; GLUCOSE
AB Background: There have been increasing indications about an epigenetically-based elevated predisposition of assisted reproductive technology (ART) offspring to insulin resistance, which can lead to an unfavorable cardio-metabolic profile in adult life. However, the relevant long-term systematic molecular studies are limited, especially for the IntraCytoplasmic Sperm Injection (ICSI) method, introduced in 1992. In this study, we carefully defined a group of 42 prepubertal ICSI and 42 naturally conceived (NC) children. We assessed differences in their metabolic profile based on biochemical measurements, while, for a subgroup, plasma metabolomic analysis was also performed, investigating any relevant insulin resistance indices.
   Methods & Results: Auxological and biochemical parameters of 42 6.8 +/- 2.1 yrs old ICSI-conceived and 42 age-matched controls were measured. Significant differences between the groups were determined using univariate and multivariate statistics, indicating low urea and low-grade inflammation markers (YKL-40, hsCRP) and high triiodothyronine (T3) in ICSI-children compared to controls. Moreover, plasma metabolomic analysis carried out for a subgroup of 10 ICSI-and 10 NC girls using Gas Chromatography-Mass Spectrometry (GC-MS) indicated clear differences between the two groups, characterized by 36 metabolites linked to obesity, insulin resistance and metabolic syndrome. Notably, the distinction between the two girl subgroups was accentuated when both their biochemical and metabolomic measurements were employed.
   Conclusions: The present study contributes a large auxological and biochemical dataset of a well-defined group of prepubertal ICSI-conceived subjects to the research of the ART effect to the offspring's health. Moreover, it is the first time that the relevant usefulness of metabolomics was investigated. The acquired results are consistent with early insulin resistance in ICSI-offspring, paving the way for further systematic investigations. These data support that metabolomics may unravel metabolic differences before they become clinically or biochemically evident, underlining its utility in the ART research.
C1 [Gkourogianni, Alexandra; Kosteria, Ioanna; Konsta, Maria; Kanaka-Gantenbein, Christina; Chrousos, George P.] Univ Athens Med Sch, Dept Pediat 1, Div Endocrinol Diabet & Metab, Athens, Greece.
   [Telonis, Aristeidis G.; Klapa, Maria I.] Fdn Res & Technol Hellas FORTH ICE HT, Inst Chem Engn Sci, Metab Engn & Syst Biol Lab, Patras, Greece.
   [Margeli, Alexandra; Papassotiriou, Ioannis] Aghia Sophia Childrens Hosp, Dept Clin Biochem, Athens, Greece.
   [Mantzou, Emilia] Evgenid Hosp, Dept Endocrinol & Metab, Endocrine Unit, Athens, Greece.
   [Loutradis, Dimitrios] Univ Athens Med Sch, Div In Vitro Fertilizat, Dept Obstet & Gynecol 1, Athens, Greece.
   [Mastorakos, George] Univ Athens Med Sch, Div Endocrinol, Dept Obstet & Gynecol 2, Athens, Greece.
   [Telonis, Aristeidis G.] Univ Patras, Dept Biol, Grad Program Biol Technol, GR-26110 Patras, Greece.
C3 National & Kapodistrian University of Athens; Foundation for Research &
   Technology - Hellas (FORTH); Institute of Chemical Engineering Sciences
   (ICE-HT); The Aghia Sophia Children's Hospital; National & Kapodistrian
   University of Athens; National & Kapodistrian University of Athens;
   University of Patras
RP Chrousos, GP (corresponding author), Univ Athens Med Sch, Dept Pediat 1, Div Endocrinol Diabet & Metab, Athens, Greece.
EM chrousog@mail.nih.gov
RI Kosteria, Ioanna/AAJ-3492-2020; Kanaka-Gantenbein,
   Christina/AAP-3697-2020; KLAPA, MARIA/ITT-8426-2023; Chrousos,
   George/G-8702-2011
OI Telonis, Aristeidis/0000-0003-1575-2769; MANTZOU,
   EMILIA/0000-0001-6606-8647
FU University of Athens; First Pediatric Clinic; FORTH/ICE-HT internal
   funds; Panhellenic Endocrinology Society
FX The study was funded by University of Athens, First Pediatric Clinic and
   FORTH/ICE-HT internal funds and a fellowship of Panhellenic
   Endocrinology Society to Dr. Alexandra Gkourogianni. The funders had no
   role in study design, data collection and analysis, decision to publish,
   or preparation of the manuscript.
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NR 48
TC 41
Z9 45
U1 0
U2 8
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD APR 11
PY 2014
VL 9
IS 4
AR e94001
DI 10.1371/journal.pone.0094001
PG 11
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA AI3CI
UT WOS:000336736200034
PM 24728198
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Trasande, L
   Sathyanarayana, S
   Trachtman, H
AF Trasande, Leonardo
   Sathyanarayana, Sheela
   Trachtman, Howard
TI Dietary Phthalates and Low-Grade Albuminuria in US Children and
   Adolescents
SO CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
LA English
DT Article
ID FOCAL SEGMENTAL GLOMERULOSCLEROSIS; BISPHENOL-A; NATIONAL-HEALTH;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; OXIDATIVE STRESS;
   BLOOD-PRESSURE; TOBACCO-SMOKE; EXPOSURE; POPULATION
AB BackgroundLow-grade albuminuria is an indicator of endothelial dysfunction and is associated with an increased risk of cardiovascular disease. A graded level of exposure to bisphenol A was recently identified to be associated with increased risk of low-grade albuminuria in children and adults. Because bisphenol A and phthalates coexist as dietary contaminants, this study investigated whether exposure to phthalates is also associated with low-grade albuminuria.Design, setting, participants, & measurementsData were examined from 667 children who participated in the 2009-2010 National Health and Nutrition Examination Survey and who had results for urinary phthalate metabolites and albumin excretion. Urinary albumin and creatinine concentrations were measured in a first morning specimen using a solid-phase fluorescent immunoassay and a Roche/Hitachi Modular P Chemistry Analyzer with an enzymatic method, respectively. Phthalate metabolites were analyzed in a separate spot urine sample from each participant, using high-performance liquid chromatography and tandem mass spectroscopy.ResultsFor each (roughly) 3-fold increase in metabolites of di-2-ethylhexylphthalate (a high molecular weight phthalate commonly found in foods), a 0.55 mg/g increase in albumin/creatinine ratio (ACR) was identified (P=0.02), whereas a 1.30-fold odds of a higher ACR quartile was also identified for each (roughly) 3-fold increase (P=0.02). Higher ACR was not identified in relationship to metabolites of lower molecular phthalates commonly found in lotions or shampoos, suggesting specificity.ConclusionsAlthough reverse causation and unmeasured confounders represent alternative explanations, these findings, in conjunction with our earlier data on bisphenol A, indicate that a wide array of environmental toxins may adversely affect albuminuria and potentially increase the risk of cardiovascular disease. In view of the potential long-term health implications of ongoing exposure in this vulnerable subpopulation, our data support both further study and renewed regulatory efforts to limit exposure during childhood.
C1 [Trasande, Leonardo; Trachtman, Howard] NYU, Sch Med, Dept Pediat, New York, NY 10016 USA.
   [Trasande, Leonardo] NYU, Sch Med, Dept Environm Med, New York, NY 10016 USA.
   [Trasande, Leonardo] NYU, Sch Med, Dept Populat Hlth, New York, NY 10016 USA.
   [Trasande, Leonardo] NYU, Wagner Sch Publ Serv, New York, NY 10016 USA.
   [Trasande, Leonardo] NYU, Steinhardt Sch Culture Educ & Human Dev, Dept Nutr Food & Publ Hlth, New York, NY 10016 USA.
   [Sathyanarayana, Sheela] Univ Washington, Seattle Childrens Res Inst, Seattle, WA 98195 USA.
C3 New York University; New York University; New York University; New York
   University; New York University; University of Washington; University of
   Washington Seattle; Seattle Children's Hospital
RP Trachtman, H (corresponding author), NYU, Langone Med Ctr, CTSI, Dept Pediat, Room 110,227 E 30th St, New York, NY 10016 USA.
EM howard.trachtman@nyumc.org
RI Trachtman, Howard/GSE-2340-2022; Trasande, Leonardo/ABE-6339-2020
OI Trachtman, Howard/0000-0001-7447-9489; Trasande,
   Leonardo/0000-0002-1928-597X
FU Kids of NYU Foundation
FX The authors thank Adam Spanier, Jan Blustein, Elaine Urbina, and Teresa
   Attina for their support in related manuscripts that examine
   associations of phthalate metabolites with cardiovascular and body mass
   outcomes. We thank the Kids of NYU Foundation for support of this work.
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NR 52
TC 60
Z9 63
U1 0
U2 17
PU AMER SOC NEPHROLOGY
PI WASHINGTON
PA 1401 H Street NW, Suite 900, WASHINGTON, DC 20005, UNITED STATES
SN 1555-9041
EI 1555-905X
J9 CLIN J AM SOC NEPHRO
JI Clin. J. Am. Soc. Nephrol.
PD JAN 7
PY 2014
VL 9
IS 1
BP 100
EP 109
DI 10.2215/CJN.04570413
PG 10
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 285AL
UT WOS:000329364700015
PM 24178978
OA Green Published
DA 2025-06-11
ER

PT J
AU Hosick, PA
   AlAmodi, AA
   Storm, MV
   Gousset, MU
   Pruett, BE
   Gray, W
   Stout, J
   Stec, DE
AF Hosick, P. A.
   AlAmodi, A. A.
   Storm, M. V.
   Gousset, M. U.
   Pruett, B. E.
   Gray, W., III
   Stout, J.
   Stec, D. E.
TI Chronic carbon monoxide treatment attenuates development of obesity and
   remodels adipocytes in mice fed a high-fat diet
SO INTERNATIONAL JOURNAL OF OBESITY
LA English
DT Article
DE heme oxygenase; metabolism; insulin resistance; oxygen consumption;
   diabetes
ID CARDIAC MITOCHONDRIAL BIOGENESIS; IMPROVES INSULIN SENSITIVITY;
   INCREASES ADIPONECTIN LEVELS; HEME OXYGENASE; HIGH-ALTITUDE; METABOLIC
   SYNDROME; OXIDATIVE STRESS; RESCUES MICE; CO; ADIPOSITY
AB OBJECTIVE: Induction of heme oxygenase-1 (HO-1) has been demonstrated to result in chronic weight loss in several rodent models of obesity. However, the specific contribution of the HO metabolite, carbon monoxide (CO) to this response remains unknown. In this study, we determined the effect of chronic low level administration of a specific CO donor on the progression of obesity and its effects on metabolism and adipocyte biology in mice fed a high-fat diet.
   DESIGN: Experiments were performed on C57BL/6J mice fed a high-fat diet (60%) from 4 weeks until 30 weeks of age. Mice were administered either the CO donor, carbon monoxide releasing molecules (CORM)-A1 (5mg kg(-1), intraperitoneally every other day) or the inactive form of the drug (iCORM-A1). Body weights were measured weekly and fasted blood glucose, insulin as well as body composition were measured every 6 weeks. Food intake, O-2 consumption, CO2 production, activity and body heat production were measured at 28 weeks after start of the experimental protocol.
   RESULTS: Chronic CORM-A1 attenuated the development of high fat induced obesity from 18 weeks until the end of the study. Chronic CORM-A1 treatment in mice fed a high-fat diet resulted in significant decreases in fasted blood glucose, insulin and body fat and increased O-2 consumption and heat production as compared with mice treated with iCORM-A1. Chronic CORM-A1 treatment also resulted in a significant decrease in adipocyte size and an increase in adipocyte number and in NRF-1, PGC-1 alpha and UCP1 protein levels in epidydmal fat.
   CONCLUSION: Our results demonstrate that chronic CO treatment prevents the development of high-fat diet induced obesity via stimulation of metabolism and remodeling of adipocytes.
C1 [Hosick, P. A.; AlAmodi, A. A.; Storm, M. V.; Gousset, M. U.; Pruett, B. E.; Gray, W., III; Stout, J.; Stec, D. E.] Univ Mississippi, Med Ctr, Dept Physiol & Biophys, Ctr Excellence Cardiovasc Renal Res, Jackson, MS 39216 USA.
C3 University of Mississippi Medical Center; University of Mississippi
RP Stec, DE (corresponding author), Univ Mississippi, Med Ctr, Dept Physiol & Biophys, Ctr Excellence Cardiovasc Renal Res, Jackson, MS 39216 USA.
EM dstec@umc.edu
FU National Heart, Lung and Blood Institute [PO1HL-51971, HL088421,
   1T32HL105324]
FX The authors would like to acknowledge the support of grants from the
   National Heart, Lung and Blood Institute, PO1HL-51971, HL088421 (DES)
   and 1T32HL105324 (PAH). The authors gratefully acknowledge the
   Analytical and Assay Core Laboratory in the Department of Physiology and
   Biophysics at the University of Mississippi Medical Center.
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NR 41
TC 49
Z9 53
U1 0
U2 13
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0307-0565
EI 1476-5497
J9 INT J OBESITY
JI Int. J. Obes.
PD JAN
PY 2014
VL 38
IS 1
BP 132
EP 139
DI 10.1038/ijo.2013.61
PG 8
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 284UD
UT WOS:000329345700020
PM 23689359
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Kim, JH
   Lee, DC
AF Kim, Jung-Ha
   Lee, Duk-Chul
TI Mitochondrial DNA Copy Number in Peripheral Blood Is Associated with
   Femoral Neck Bone Mineral Density in Postmenopausal Women
SO JOURNAL OF RHEUMATOLOGY
LA English
DT Article
DE BONE DENSITY; MITOCHONDRIAL DNA; OSTEOPOROSIS; POSTMENOPAUSAL;
   LEUKOCYTES
ID OXIDATIVE-STRESS; MONONUCLEAR-CELLS; HEALTHY WOMEN;
   CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; OSTEOPOROSIS; RISK;
   ADIPONECTIN; MUSCLE; DYSFUNCTION
AB Objective. It has been suggested that mitochondrial dysfunction is related to aging and metabolic disorders. Yet there are few studies of the relationship between bone mineral density (BMD) and mitochondrial content in humans. We investigated the relationship between BMD and mitochondria! DNA (mtDNA) copy number in peripheral blood of postmenopausal women.
   Methods. The study included 146 postmenopausal women. Enrolled subjects were taking no medications and had no disorders that altered bone metabolism. We measured BMD using dual-energy x-ray absorptiometry and leukocyte mtDNA copy number using real-time polymerase chain reaction. Anthropometric evaluations and biochemical tests were performed.
   Results. Patients with osteopenia or osteoporosis had lower mtDNA copy numbers than normal subjects (p < 0.0001). Femoral neck BMD was negatively correlated with age (r = -0.01, p = 0.04) and with serum levels of adiponectin (r = -0.22, p = 0.01) and osteocalcin (r = -0.31, p = 0.0001). Serum levels of 25-OH vitamin D (r = 0.32, p < 0.0001) and mtDNA copy number (r = 0.36, p < 0.0001) were positively correlated with femoral neck BMD. Multiple regression analysis showed that mtDNA copy number (B = 0.156, p < 0.001) was an independent factor associated with femoral neck BMD after adjustment for age, body mass index, waist circumference, waist-hip ratio, blood pressure, homeostatic model assessment of insulin resistance, high-sensitivity C-reactive protein, adiponectin, osteocalcin, homocysteine, lipid profiles, 25-OH vitamin D, and regular exercise. mtDNA copy number was not related to lumbar BMD.
   Conclusion. Low mtDNA content in peripheral blood is related to decreased femoral neck BMD in postmenopausal women. Our findings suggest that mitochondrial dysfunction may be a potential pathophysiologic mechanism of osteoporosis in postmenopausal women. (First Release May 15 2012; J Rheumatol 2012;39:1465-72; doi:10.3899/jrheum.111444)
C1 [Lee, Duk-Chul] Yonsei Univ, Coll Med, Severance Hosp, Dept Family Med, Seoul 120752, South Korea.
   [Kim, Jung-Ha] Chung Ang Univ, Healthcare Ctr, Dept Family Med, Seoul 156756, South Korea.
C3 Yonsei University; Yonsei University Health System; Chung Ang University
RP Lee, DC (corresponding author), Yonsei Univ, Coll Med, Severance Hosp, Dept Family Med, 250 Seongsanno, Seoul 120752, South Korea.
EM faith@yuhs.ac
RI Kim, Eun-Ji/HHN-4611-2022
OI , Jung-Ha/0000-0002-7630-9501; Lee, Duk Chul/0000-0001-9166-1813
FU Chung-Ang University
FX Supported by Chung-Ang University Research Grants in 2011.
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NR 63
TC 10
Z9 12
U1 0
U2 7
PU J RHEUMATOL PUBL CO
PI TORONTO
PA 365 BLOOR ST E, STE 901, TORONTO, ONTARIO M4W 3L4, CANADA
SN 0315-162X
EI 1499-2752
J9 J RHEUMATOL
JI J. Rheumatol.
PD JUL
PY 2012
VL 39
IS 7
BP 1465
EP 1472
DI 10.3899/jrheum.111444
PG 8
WC Rheumatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Rheumatology
GA 973VQ
UT WOS:000306388300025
PM 22589267
OA Bronze
DA 2025-06-11
ER

PT J
AU Negi, SI
   Pankow, JS
   Fernstrom, K
   Hoogeveen, RC
   Zhu, N
   Couper, D
   Schmidt, MI
   Duncan, BB
   Ballantyne, CM
AF Negi, Smita I.
   Pankow, James S.
   Fernstrom, Karl
   Hoogeveen, Ron C.
   Zhu, Na
   Couper, David
   Schmidt, Maria I.
   Duncan, Bruce B.
   Ballantyne, Christie M.
TI Racial Differences in Association of Elevated Interleukin-18 Levels With
   Type 2 Diabetes The Atherosclerosis Risk in Communities Study
SO DIABETES CARE
LA English
DT Article
ID INSULIN-RESISTANCE; METABOLIC SYNDROME; CIRCULATING LEVELS; OXIDATIVE
   STRESS; ADIPOSE-TISSUE; INFLAMMATION; ADIPONECTIN; RECEPTOR; MEDIATORS;
   MELLITUS
AB OBJECTIVE-Elevated plasma interleukin-18 (IL-18) has been linked to onset of diabetes mellitus (DM) and its complications. However, so far this association has been shown only in predominantly white populations. We examined IL-18 levels and their association with incident DM in a racially heterogeneous population.
   RESEARCH DESIGN AND METHODS-In a nested case-cohort design representing a 9-year follow-up of 9,740 middle-aged, initially healthy, nondiabetic white and African American participants of the Atherosclerosis Risk in Communities Study, we selected and measured analytes on race-stratified (50% white, 50% African American) random samples of both cases of incident diabetes (n = 548) and eligible members of the full cohort (n = 536).
   RESULTS-Baseline IL-18 levels were significantly higher in white participants compared with African American participants (P < 0.001). Although white participants in the fourth (versus first) quartile of IL-18 levels had a significant hazard ratio (HR) for developing DM (HR: 2.1, 95% CI: 1.3-3.4), after adjustment for age, sex, and study center, no difference was seen among African Americans (HR: 1.0, 95% CI: 0.6-1.7). Unlike those in African Americans, IL-18 levels in whites had a significant correlation with age (P < 0.01); anthropometric characteristics such as waist circumference (P < 0.001), height (P = 0.04), waist-to-hip ratio (P < 0.001), and BMI (P < 0.01); and total (P < 0.001) and high-molecular-weight (P < 0.001) adiponectin.
   CONCLUSIONS-There are racial differences in levels of IL-18 and the association of IL-18 with risk factors and incident type 2 DM. In addition, there seems to be a complex interplay of inflammation and adiposity in the development of DM.
C1 [Negi, Smita I.; Hoogeveen, Ron C.; Ballantyne, Christie M.] Baylor Coll Med, Sect Cardiovasc Res, Houston, TX 77030 USA.
   [Negi, Smita I.; Hoogeveen, Ron C.; Ballantyne, Christie M.] Methodist DeBakey Heart Ctr, Ctr Cardiovasc Dis Prevent, Houston, TX USA.
   [Pankow, James S.; Fernstrom, Karl; Zhu, Na] Univ Minnesota, Sch Publ Hlth, Div Epidemiol & Community Hlth, Minneapolis, MN USA.
   [Couper, David] Univ N Carolina, Sch Publ Hlth, Chapel Hill, NC USA.
   [Schmidt, Maria I.; Duncan, Bruce B.] Univ Fed Rio Grande do Sul, Sch Med, Grad Studies Program Epidemiol, Porto Alegre, RS, Brazil.
C3 Baylor College of Medicine; Houston Methodist; University of Minnesota
   System; University of Minnesota Twin Cities; University of North
   Carolina; University of North Carolina Chapel Hill; Universidade Federal
   do Rio Grande do Sul
RP Ballantyne, CM (corresponding author), Baylor Coll Med, Sect Cardiovasc Res, Houston, TX 77030 USA.
EM cmb@bcm.tmc.edu
RI Schmidt, Maria/V-3196-2019; Ballantyne, Christie/A-6599-2008; Duncan,
   Bruce/L-4140-2016
OI Hoogeveen, Ron/0000-0003-2399-4653; Pankow, James/0000-0001-7076-483X;
   Duncan, Bruce/0000-0002-7491-2630; Couper, David/0000-0002-4313-9235;
   Ballantyne, Christie/0000-0002-6432-1730
FU National Heart, Lung, and Blood Institute [HHSN268201100005C,
   HHSN268201100006C, HHSN268201100007C, HHSN268201100008C,
   HHSN268201100009C, HHSN268201100010C, HHSN268201100011C,
   HHSN268201100012C]; National Institute of Diabetes and Digestive and
   Kidney Diseases Grant [R01-DK-56918]
FX ARIC is carried out as a collaborative study supported by National
   Heart, Lung, and Blood Institute Contracts HHSN268201100005C,
   HHSN268201100006C, HHSN2682011.00007C, HHSN268201100008C,
   HHSN268201100009C, HHSN268201100010C, HHSN268201100011C, and
   HHSN268201100012C. The current study was also supported by National
   Institute of Diabetes and Digestive and Kidney Diseases Grant
   R01-DK-56918.
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NR 29
TC 15
Z9 16
U1 0
U2 2
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0149-5992
J9 DIABETES CARE
JI Diabetes Care
PD JUL
PY 2012
VL 35
IS 7
BP 1513
EP 1518
DI 10.2337/dc11-1957
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 962MJ
UT WOS:000305548900020
PM 22596175
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Cosselman, KE
   Krishnan, RM
   Oron, AP
   Jansen, K
   Peretz, A
   Sullivan, JH
   Larson, TV
   Kaufman, JD
AF Cosselman, Kristen E.
   Krishnan, Ranjini M.
   Oron, Assaf P.
   Jansen, Karen
   Peretz, Alon
   Sullivan, Jeffrey H.
   Larson, Timothy V.
   Kaufman, Joel D.
TI Blood Pressure Response to Controlled Diesel Exhaust Exposure in Human
   Subjects
SO HYPERTENSION
LA English
DT Article
DE air pollution; diesel exhaust; cardiovascular; blood pressure; autonomic
   nervous system
ID AIR-POLLUTION EXPOSURE; PARTICULATE MATTER; OXIDATIVE STRESS;
   INHALATION; ADULTS; DYSFUNCTION; ACTIVATION; PARTICLES
AB Exposure to traffic-related air pollution is associated with risk of cardiovascular disease and mortality. We examined whether exposure to diesel exhaust increased blood pressure (BP) in human subjects. We analyzed data from 45 nonsmoking subjects, 18 to 49 years of age in double-blinded, crossover exposure studies, randomized to order. Each subject was exposed to diesel exhaust, maintained at 200 mu g/m(3) of fine particulate matter, and filtered air for 120 minutes on days separated by >= 2 weeks. We measured BP pre-exposure, at 30-minute intervals during exposure, and 3, 5, 7, and 24 hours from exposure initiation and analyzed changes from pre-exposure values. Compared with filtered air, systolic BP increased at all of the points measured during and after diesel exhaust exposure; the mean effect peaked between 30 and 60 minutes after exposure initiation (3.8 mm Hg [957 CI: -0.4 to 8.0 mm Hg] and 5.1 mm Hg [95% Cl: 0.7-9.5 mm Hg], respectively). Sex and metabolic syndrome did not modify this effect. Combining readings between 30 and 90 minutes, diesel exhaust exposure resulted in a 4 4-mm Hg increase in systolic BP, adjusted for participant characteristics and exposure perception (95% Cl: 1.1-7.7 mm Hg, P=0.0009). There was no significant effect on heart rate or diastolic pressure. Diesel exhaust inhalation was associated with a rapid, measurable increase in systolic but not diastolic BP in young nonsmokers, independent of perception of exposure. This controlled trial in humans confirms findings from observational studies. The effect may be important on a population basis given the worldwide prevalence of exposure to traffic-related air pollution. (Hypertension. 2012;59:943-948.) . Online Data Supplement
C1 [Cosselman, Kristen E.; Krishnan, Ranjini M.; Oron, Assaf P.; Jansen, Karen; Peretz, Alon; Sullivan, Jeffrey H.; Larson, Timothy V.; Kaufman, Joel D.] Univ Washington, Dept Environm & Occupat Hlth Sci, Seattle, WA 98105 USA.
   [Krishnan, Ranjini M.; Kaufman, Joel D.] Univ Washington, Dept Med, Seattle, WA 98105 USA.
   [Larson, Timothy V.] Univ Washington, Dept Civil & Environm Engn, Seattle, WA 98105 USA.
C3 University of Washington; University of Washington Seattle; University
   of Washington; University of Washington Seattle; University of
   Washington; University of Washington Seattle
RP Kaufman, JD (corresponding author), Univ Washington, Dept Environm & Occupat Hlth Sci, Box 354695,4225 Roosevelt Way NE,Suite 302, Seattle, WA 98105 USA.
EM joelk@u.washington.edu
RI Kaufman, Joel/B-5761-2008
OI Kaufman, Joel/0000-0003-4174-9037
FU National Institute of Environmental Health Sciences [K24ES013195,
   P30ES07033, P50ES015915]; Environmental Protection Agency [R830954,
   R827355]; EPA [R830954, 1100018] Funding Source: Federal RePORTER
FX This study was supported by funding from the National Institute of
   Environmental Health Sciences grants K24ES013195, P30ES07033, and
   P50ES015915 and Environmental Protection Agency grants R830954 and
   R827355.
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NR 25
TC 103
Z9 122
U1 2
U2 20
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0194-911X
EI 1524-4563
J9 HYPERTENSION
JI Hypertension
PD MAY
PY 2012
VL 59
IS 5
BP 943
EP +
DI 10.1161/HYPERTENSIONAHA.111.186593
PG 12
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 938VH
UT WOS:000303760900022
PM 22431582
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Farrell, GC
   van Rooyen, D
   Gan, L
   Chitturi, S
AF Farrell, Geoffrey C.
   van Rooyen, Derrick
   Gan, Lay
   Chitturi, Shivrakumar
TI NASH is an Inflammatory Disorder: Pathogenic, Prognostic and Therapeutic
   Implications
SO GUT AND LIVER
LA English
DT Review
DE Non-alcoholic fatty liver disease; Hepatic fibrosis; Non-alcoholic
   steatohepatitis
ID NONALCOHOLIC FATTY LIVER; ENDOPLASMIC-RETICULUM STRESS; NF-KAPPA-B;
   ACTIVATED-RECEPTOR-ALPHA; NECROSIS-FACTOR-ALPHA; TOLL-LIKE RECEPTORS;
   INCREASED INTESTINAL PERMEABILITY; HEPATIC CYTOCHROME-P450 2E1; DOSE
   URSODEOXYCHOLIC ACID; UNFOLDED PROTEIN RESPONSE
AB While non-alcoholic fatty liver disease (NAFLD) is highly prevalent (15% to 45%) in modern societies, only 10% to 25% of cases develop hepatic fibrosis leading to cirrhosis, end-stage liver disease or hepatocellular carcinoma. Apart from pre-existing fibrosis, the strongest predictor of fibrotic progression in NAFLD is steatohepatitis or non-alcoholic steatohepatitis (NASH). The critical features other than steatosis are hepatocellular degeneration (ballooning, Mallory hyaline) and mixed inflammatory cell infiltration. While much is understood about the relationship of steatosis to metabolic factors (over-nutrition, insulin resistance, hyperglycemia, metabolic syndrome, hypoadiponectinemia), less is known about inflammatory recruitment, despite its importance for the perpetuation of liver injury and fibrogenesis. In this review, we present evidence that liver inflammation has prognostic significance in NAFLD. We then consider the origins and components of liver inflammation in NASH. Hepatocytes injured by toxic lipid molecules (lipotoxicity) play a central role in the recruitment of innate immunity involving Toll-like receptors (TLRs), Kupffer cells (KCs), lymphocytes and neutrophils and possibly inflammasome. The key pro-inflammatory signaling pathways in NASH are nuclear factor-kappa B (NF-kappa B) and c-Jun N-terminal kinase (JNK). The downstream effectors include adhesion molecules, chemokines, cytokines and the activation of cell death pathways leading to apoptosis. The upstream activators of NF-kappa B and JNK are more contentious and may depend on the experimental model used. TLRs are strong contenders. It remains possible that inflammation in NASH originates outside the liver and in the gut microbiota that prime KC/TLR responses, inflamed adipose tissue and circulating inflammatory cells. We briefly review these mechanistic considerations and project their implications for the effective treatment of NASH. (Gut Liver 2012;6:149-171)
C1 [Farrell, Geoffrey C.; van Rooyen, Derrick; Gan, Lay; Chitturi, Shivrakumar] Australian Natl Univ, Sch Med, Canberra Hosp, Gastroenterol & Hepatol Unit, Garran, Australia.
C3 Australian National University; Canberra Hospital
RP Farrell, GC (corresponding author), Canberra Hosp, Gastroenterol & Hepatol Unit, GPO Box 100, Woden, ACT 2605, Australia.
EM Geoff.Farrell@anu.edu.au
OI Chitturi, Shivakumar/0000-0002-2367-9859
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NR 237
TC 315
Z9 363
U1 1
U2 141
PU EDITORIAL OFFICE GUT & LIVER
PI SEOUL
PA 305 LOTTE GOLD ROSE II, 890-59, DAECHI 4-DONG, GANGNAM-GU, SEOUL,
   135-839, SOUTH KOREA
SN 1976-2283
EI 2005-1212
J9 GUT LIVER
JI Gut Liver
PD APR
PY 2012
VL 6
IS 2
BP 149
EP 171
DI 10.5009/gnl.2012.6.2.149
PG 23
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 930JZ
UT WOS:000303137000002
PM 22570745
OA gold, Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Wiersma, H
   Gatti, A
   Nijstad, N
   Kuipers, F
   Tietge, UJF
AF Wiersma, Harmen
   Gatti, Alberto
   Nijstad, Niels
   Kuipers, Folkert
   Tietge, Uwe J. F.
TI Hepatic SR-BI, not endothelial lipase, expression determines biliary
   cholesterol secretion in mice
SO JOURNAL OF LIPID RESEARCH
LA English
DT Article
DE bile; EL; HDL; liver; LXR; metabolism; phospholipase; SREBP
ID HIGH-DENSITY-LIPOPROTEIN; APOLIPOPROTEIN-A-I; HDL CHOLESTEROL;
   DIETARY-CHOLESTEROL; METABOLIC SYNDROME; ABC TRANSPORTERS; PLASMA HDL;
   APOA-I; RECEPTOR; VIVO
AB High density lipoprotein cholesterol is thought to represent a preferred source of sterols secreted into bile following hepatic uptake by scavenger receptor class B type I (SR-BI). The present study aimed to determine the metabolic effects of an endothelial lipase (EL)-mediated stimulation of HDL cholesterol uptake on liver lipid metabolism and biliary cholesterol secretion in wild-type, SR-BI knockout, and SR-BI overexpressing mice. In each model, injection of an EL expressing adenovirus decreased plasma HDL cholesterol (P < 0.001) whereas hepatic cholesterol content increased (P < 0.05), translating into decreased expression of sterol-regulatory element binding protein 2 (SREBP2) and its target genes HMG-CoA reductase and LDL receptor (each P < 0.01). Biliary cholesterol secretion was dependent on hepatic SR-BI expression, being decreased in SR-BI knockouts (P < 0.001) and increased following hepatic SR-BI overexpression (P < 0.001). However, in each model, biliary secretion of cholesterol, bile acids, and phospholipids as well as fecal bile acid and neutral sterol content, remained unchanged in response to EL overexpression. Importantly, hepatic ABCG5/G8 expression did not correlate with biliary cholesterol secretion rates under these conditions. These results demonstrate that an acute decrease of plasma HDL cholesterol levels by overexpressing EL increases hepatic cholesterol content but leaves biliary sterol secretion unaltered. Instead, biliary cholesterol secretion rates are related to the hepatic expression level of SR-BI. These data stress the importance of SR-BI for biliary cholesterol secretion and might have relevance for concepts of reverse cholesterol transport.-Wiersma, H., A. Gatti, N. Nijstad, F. Kuipers, and U. J. F. Tietge. Hepatic SR-BI, not endothelial lipase, expression determines biliary cholesterol secretion in mice. J. Lipid Res. 2009. 50: 1571-1580.
C1 [Wiersma, Harmen; Gatti, Alberto; Nijstad, Niels; Kuipers, Folkert; Tietge, Uwe J. F.] Univ Groningen, Dept Pediat, Univ Med Ctr Groningen, Ctr Liver Digest & Metab Dis, NL-9700 AB Groningen, Netherlands.
C3 University of Groningen
RP Tietge, UJF (corresponding author), Univ Groningen, Dept Pediat, Univ Med Ctr Groningen, Ctr Liver Digest & Metab Dis, NL-9700 AB Groningen, Netherlands.
EM u_tietge@yahoo.com
RI Gatti, Alberto/JXX-8630-2024; Kuipers, Folkert/JZD-2819-2024
OI Kuipers, Folkert/0000-0003-2518-737X
FU Netherlands Organization for Scientific Research [917-56-358]
FX This work was supported by the Netherlands Organization for Scientific
   Research VIDI Grant 917-56-358 ( U. J. F. T.).
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NR 47
TC 40
Z9 47
U1 0
U2 2
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0022-2275
EI 1539-7262
J9 J LIPID RES
JI J. Lipid Res.
PD AUG
PY 2009
VL 50
IS 8
BP 1571
EP 1580
DI 10.1194/jlr.M800434-JLR200
PG 10
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 470CF
UT WOS:000267949900008
PM 19252221
OA Green Accepted, Green Published
DA 2025-06-11
ER

PT J
AU Orellano, MS
   Scelza-Figueredo, A
   Mauriz, LL
   Sétula, C
   Argañarás, M
   Atorrasagasti, C
   Perone, MJ
   Andreone, L
AF Orellano, Miranda Sol
   Scelza-Figueredo, Andrea
   Mauriz, Lucia Lameroli
   Setula, Carolina
   Arganaras, Milagros
   Atorrasagasti, Catalina
   Perone, Marcelo Javier
   Andreone, Luz
TI A dissociated glucocorticoid receptor modulator mitigates
   glucolipotoxicity in the endocrine pancreas and peripheral tissues:
   Preclinical data from a mouse model of diet-induced type 2 diabetes
SO LIFE SCIENCES
LA English
DT Article
DE SEGRAM; Type 2 diabetes; Inflammation; Insulin; Pancreatic islets; n
   -Cell
ID BETA-CELL DYSFUNCTION; INSULIN-RESISTANCE; MOLECULAR-MECHANISMS;
   ADIPOSE-TISSUE; PLANT-ORIGIN; COMPOUND; OBESITY; PREVENTION; MANAGEMENT;
   STRESS
AB Aims: Type 2 diabetes (T2D) is a prevalent metabolic disease linked to obesity and metabolic syndrome (MS). The glucolipotoxic environment (GLT) impacts tissues causing low-grade inflammation, insulin resistance and the gradual loss of pancreatic n-cell function, leading to hyperglycemia. We have previously shown that Compound A (CpdA), a plant-derived dissociative glucocorticoid receptor-modulator with inflammation-suppressive activity, displays protective effects on n-cells in type 1 diabetes murine models. This study aimed to evaluate whether the administration of CpdA can attenuate GLT effects and improve pathophysiological parameters in a murine model of T2D/MS. Main methods: Eight-week-old male C57BL/6NCrl mice were fed either a standard chow diet or a high-fat/highsucrose diet (HFHS) for 15 weeks. From week 5 of feeding, each group received i.p. injections of CpdA (2.5 mu g/g) or vehicle three times a week. We also examined CpdA in vitro effect against GLT using the insulinoma cell line INS-1E and na & iuml;ve isolated mouse islets. Key findings: CpdA administration in HFHS fed mice improved glucose homeostasis and insulin sensitivity with no apparent side effects. CpdA treatment also preserved pancreatic islet architecture and insulin expression, while reducing hepatic steatosis and visceral adipose tissue inflammation induced by HFHS diet. In vitro assays in INS1E cells and na & iuml;ve isolated mouse islets demonstrated that CpdA counteracted GLT-induced inhibition of glucosestimulated insulin secretion and supported the expression of key n-cell identity genes under GLT conditions. Significance: These findings highlight the potential protective effect of CpdA in preserving n-cell functionality and peripheral tissue physiology in the context of T2D/MS.
C1 [Orellano, Miranda Sol; Scelza-Figueredo, Andrea; Perone, Marcelo Javier; Andreone, Luz] Univ Austral, CONICET, Inst Invest Med Traslac IIMT, Immuno Endocrinol Diabet & Metab Lab, Pilar, Argentina.
   [Orellano, Miranda Sol; Scelza-Figueredo, Andrea; Mauriz, Lucia Lameroli; Atorrasagasti, Catalina; Perone, Marcelo Javier; Andreone, Luz] Univ Austral, Fac Ciencias Biomed, Pilar, Argentina.
   [Mauriz, Lucia Lameroli; Atorrasagasti, Catalina] Univ Austral, CONICET, Expt Hepatol & Gene Therapy Program, Inst Invest Med Traslac IIMT, Pilar, Argentina.
C3 Austral University; Consejo Nacional de Investigaciones Cientificas y
   Tecnicas (CONICET); Austral University; Consejo Nacional de
   Investigaciones Cientificas y Tecnicas (CONICET); Austral University
RP Andreone, L (corresponding author), Univ Austral, CONICET, Inst Invest Med Traslac IIMT, Immuno Endocrinol Diabet & Metab Lab, Pilar, Argentina.
EM landreone-conicet@austral.edu.ar
FU Agencia Nacional de Promocion Cientifica y Tecnologica (ANPCyT)
   [2018-1577, 2018-719, 2021- GRF-TII-00241]; Fundacio <acute accent>
   [2022]; Sociedad Argentina de Diabetes [2022]
FX This research was funded by grants from Agencia Nacional de Promocion
   Cientifica y Tecnologica (ANPCyT #2018-1577 to M.J.P. and #2018-719 and
   #2021- GRF-TII-00241 to L.A.) ; from Universidad Austral (#2020 to M.J.P
   and L.A.) ; from Fundacion Florencio Fiorini para la Investigacio <acute
   accent> n en Ciencias Biome <acute accent> dicas (#2022 to L.A.) and
   from Sociedad Argentina de Diabetes (#2019 to L.A. and #2022 to L.A. and
   M.J.P.) . Also, we thank the support of Facultad de Ciencias Biome
   <acute accent> dicas (Universidad Austral) and Fundacio <acute accent> n
   Marjorie para la Investigacio <acute accent> n en Diabetes (
   www.fumdiab.org.ar) .
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NR 50
TC 0
Z9 0
U1 1
U2 1
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0024-3205
EI 1879-0631
J9 LIFE SCI
JI Life Sci.
PD FEB 1
PY 2025
VL 362
AR 123363
DI 10.1016/j.lfs.2024.123363
EA JAN 2025
PG 11
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA T7V8A
UT WOS:001407042900001
PM 39761744
DA 2025-06-11
ER

PT J
AU Alhomaid, AM
   Ahmed, MM
AF Alhomaid, Ali Mohammad
   Ahmed, Muzammil Moin
TI Prevalence of Non-diabetic Hyperglycemia in Young Adults and Its Impact
   on Periodontal Health
SO CUREUS JOURNAL OF MEDICAL SCIENCE
LA English
DT Article
DE risk factor.; prevalence; periodontal medicine; diabetes; periodontitis;
   prediabetes; non-diabetic hyperglycaemia
ID NEUTROPHIL CHEMOTAXIS; METABOLIC SYNDROME; OXIDATIVE STRESS; DISEASE;
   INFLAMMATION; INDIVIDUALS; HBA1C
AB Background Non -diabetic hyperglycemia is a transitional phase of hyperglycemia that poses a hidden risk for the development of diabetes mellitus and related complications, including periodontal destruction. The current study sought to determine the prevalence of non -diabetic hyperglycemia in young adults and any possible links to periodontal health. Methods A total of 400 participants in this cross-sectional study were evaluated for non -diabetic hyperglycemia between the ages of 18 and 35 years. Group I consisted of non -diabetic hyperglycemic participants. Group II comprised an equal number of matched, healthy subjects. The groups' hyperglycemic and clinical periodontal characteristics were contrasted. Using a one -sample t -test and logistic regression analysis, the acquired data were subjected to statistical analysis. Results The prevalence of non -diabetic hyperglycemia was 19%, with men (13%) having a higher prevalence than women (6%). The mean fasting plasma glucose and hemoglobin A1c (HbA1c) levels were 114.47 +/- 6.40 mg/dL and 6.10 +/- 0.21%, respectively, for group I, and 85.72 +/- 7.24 mg/dL and 4.38 +/- 0.70% for group II. When compared to healthy controls, all periodontal parameters, including plaque index, gingival index, bleeding on probing, probing depth, and clinical attachment loss, were significantly higher in group I non -diabetic hyperglycemic patients. The regression analysis revealed statistically significant links between hyperglycemic and periodontal parameters. Conclusion The prevalence of non -diabetic hyperglycemia among young adults is a serious concern similar to that of older adults with the risk for periodontal diseases. Non -diabetic hyperglycemic considerations in young adults should be emphasized in dental and medical clinics to reduce the risk of developing diabetes mellitus and to avoid irreversible periodontal tissue damage.
C1 [Alhomaid, Ali Mohammad] Qassim Reg Dent Ctr, Dent Hyg, Buraydah, Saudi Arabia.
   [Ahmed, Muzammil Moin] Qassim Univ, Coll Appl Hlth Sci Ar Rass, Dent & Oral Hlth, Ar Rass, Saudi Arabia.
C3 Qassim University
RP Alhomaid, AM (corresponding author), Qassim Reg Dent Ctr, Dent Hyg, Buraydah, Saudi Arabia.
EM ali.qudhp@gmail.com
RI Moin Ahmed, Muzammil/M-6051-2018
OI Moin Ahmed, Muzammil/0000-0003-3497-9707
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NR 36
TC 0
Z9 0
U1 0
U2 0
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
EI 2168-8184
J9 CUREUS J MED SCIENCE
JI Cureus J Med Sci
PD FEB 8
PY 2024
VL 16
IS 2
AR 53847
DI 10.7759/cureus.53847
PG 6
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA JK7L3
UT WOS:001173125100025
PM 38465110
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Jin, YX
   Wei, DD
   Liu, PL
   Chen, F
   Li, RR
   Zhang, JY
   Zhang, RY
   Liu, ZX
   Huo, WQ
   Li, LL
   Wang, CJ
   Ban, JB
   Mao, ZX
AF Jin, Yuxi
   Wei, Dandan
   Liu, Pengling
   Chen, Fei
   Li, Rongrong
   Zhang, Jinyu
   Zhang, Ruyi
   Liu, Zuoxiang
   Huo, Wenqian
   Li, Linlin
   Wang, Chongjian
   Ban, Jinbao
   Mao, Zhenxing
TI Serum Cortisol, 25 (OH)D, and Cardiovascular Risk Factors in Patients
   with Type 2 Diabetes Mellitus
SO INTERNATIONAL JOURNAL OF ENDOCRINOLOGY
LA English
DT Article
ID VITAMIN-D DEFICIENCY; METABOLIC SYNDROME; HAIR CORTISOL; STRESS;
   ASSOCIATION; DISEASE
AB Background and Aims. The effects of cortisol on cardiovascular diseases (CVD) and CVD risk are unknown, especially in patients with type 2 diabetes mellitus (T2DM). Furthermore, it is unclear whether 25 (OH)D can alter the associations of cortisol with CVD and CVD risk factors. Thus, the present study was to investigate the associations of serum cortisol with CVD and CVD risk factors and whether 25 (OH)D altered these associations among patients with T2DM. Materials and methods. A total of 762 patients diagnosed with T2DM were recruited. The levels of serum cortisol and 25 (OH)D were measured with a liquid chromatography-tandem mass spectrometry. Logistic regression and linear regression were used to assess the association of cortisol with CVD and multiple cardiovascular risk factors. Modification analyses were performed to identify whether 25 (OH)D altered the above associations. Results. A 1 SD increase in cortisol was associated with a higher prevalence of stroke (odds ratio (OR): 1.25, 95% confidence interval (CI): 1.05, 1.50). Elevated cortisol was associated with related cardiovascular risk factors, including deceased ss cell function, high-density lipoprotein-cholesterol (HDL-C), and fasting insulin, as well as increased triglycerides (TG), low-density lipoprotein-cholesterol (LDL-C), fasting plasma glucose (FPG), and glycated hemoglobin (HbA1c). In addition, modification analyses suggested that the associations of cortisol with ss cell function, fasting insulin, FPG, and HbA1c were modified by 25 (OH)D. Conclusions. Serum cortisol was associated with the prevalence of stroke and cardiovascular risk factors, and the associations of cortisol with cardiovascular risk factors were moderated by 25 (OH)D, suggesting that T2DM patients with exposure to lower 25 (OH)D levels and higher cortisol levels were more susceptible to have higher cardiovascular risk factors.
C1 [Jin, Yuxi; Chen, Fei; Ban, Jinbao] Zhengzhou Univ, Dept Thorac Surg, Affiliated Hosp 1, Zhengzhou 450052, Peoples R China.
   [Wei, Dandan; Liu, Pengling; Zhang, Jinyu; Zhang, Ruyi; Liu, Zuoxiang; Huo, Wenqian; Li, Linlin; Wang, Chongjian; Mao, Zhenxing] Zhengzhou Univ, Coll Publ Hlth, Dept Epidemiol & Biostat, Zhengzhou, Henan, Peoples R China.
   [Li, Rongrong] Xinjiang Med Univ, Dept Oncol, Affiliated Hosp 1, Urumqi, Xinjiang, Peoples R China.
C3 Zhengzhou University; Zhengzhou University; Xinjiang Medical University
RP Ban, JB (corresponding author), Zhengzhou Univ, Dept Thorac Surg, Affiliated Hosp 1, Zhengzhou 450052, Peoples R China.; Mao, ZX (corresponding author), Zhengzhou Univ, Coll Publ Hlth, Dept Epidemiol & Biostat, Zhengzhou, Henan, Peoples R China.
EM jinyuxi1303@163.com; wei_dan2018@163.com; penglingliu2019@163.com;
   976962500@qq.com; 1061597212@qq.com; zjy970603@163.com;
   2456356909@qq.com; liuzhuodong97@163.com; huowenqian@zzu.edu.cn;
   lilinlin@zzu.edu.cn; tjwcj2005@126.com; 279654508@qq.com;
   maozhr@gmail.com
RI chen, feiyang/HDL-7230-2022; Li, Rongrong/B-8365-2019; huo,
   wenqian/O-1974-2013; luo, xiaomin/HNS-7206-2023
OI Wang, Chongjian/0000-0001-5091-6621; Huo, Wenqian/0000-0002-7898-093X;
   Jin, Yuxi/0000-0002-4344-0669
FU National Key Research and Development Program of China [2019YFC1710002];
   National Natural Science Foundation of China [42177415, 21806146];
   Postdoctoral Science Foundation of China [2020T130604, 2021M702934];
   Science and Technique Foundation of Henan Province [212102310074];
   Scientific and Technological Innovation of Colleges and Universities in
   Henan Province Talent Support Program [22HASTIT044]; Young Backbone
   Teachers Program of Colleges and Universities in Henan Province
   [2021GGJS015]; Excellent Youth Development Foundation of Zhengzhou
   University [2021ZDGGJS057]
FX The authors thank the participants, coordinators, and administrators for
   their support, and laboratory for the facility support at the School of
   Public Health, Zhengzhou University, during the study. This research was
   supported by the National Key Research and Development Program of China
   (grant no. 2019YFC1710002), National Natural Science Foundation of China
   (grant nos. 42177415 and 21806146), the Postdoctoral Science Foundation
   of China (grant nos. 2020T130604 and 2021M702934), Science and Technique
   Foundation of Henan Province (grant nos. 212102310074), Scientific and
   Technological Innovation of Colleges and Universities in Henan Province
   Talent Support Program (grant no. 22HASTIT044), Young Backbone Teachers
   Program of Colleges and Universities in Henan Province (grant no.
   2021GGJS015), and the Excellent Youth Development Foundation of
   Zhengzhou University (grant no. 2021ZDGGJS057).
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NR 34
TC 5
Z9 5
U1 4
U2 11
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1687-8337
EI 1687-8345
J9 INT J ENDOCRINOL
JI Int. J. Endocrinol.
PD JUN 18
PY 2022
VL 2022
AR 5680170
DI 10.1155/2022/5680170
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 2L7VQ
UT WOS:000817225900002
PM 35761983
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Adebayo, AA
   Oboh, G
   Ademosun, AO
AF Adebayo, Adeniyi A.
   Oboh, Ganiyu
   Ademosun, Ayokunle O.
TI Almond and date fruits enhance antioxidant status and have erectogenic
   effect: Evidence from in vitro and in vivo studies
SO JOURNAL OF FOOD BIOCHEMISTRY
LA English
DT Article
DE advanced glycated end-products; almond; arginase; date;
   phosphodiesterase-5
ID DACTYLIFERA L. CULTIVARS; OXIDATIVE STRESS; NITRIC-OXIDE; ERECTILE
   DYSFUNCTION; SEXUAL DYSFUNCTION; METABOLIC SYNDROME; REACTIVE OXYGEN;
   QUERCETIN; ACID; INFLAMMATION
AB This study was designed to investigate the efficacies of almond and date fruits on redox imbalance and enzymes relevant to the pathogenesis of erectile dysfunction. The total polyphenol contents, ferric reducing antioxidant power, and vitamin C content were determined spectrophotometrically. Phenolic and amino acid compositions were quantified using HPLC; meanwhile, the antioxidant activities were determined using DPPH, ABTS, FRAP, and metal chelation. Also, the effect of almond and date extract on advanced glycated end-products (AGEs) formation, arginase, and phosphodiesterase-5 activities was evaluated in vitro. Thereafter, the influence of almond and date supplemented diets on copulatory behaviors in normal rats was assessed, followed by arginase and phosphodiesterase-5 activities determination in vivo. The results revealed that date and almond extracts exerted antioxidant properties, prevented AGEs formation in vitro, and inhibited arginase and phosphodiesterase-5 activities in vitro and in vivo. Besides, almond and date supplemented diets significantly enhance sexual behaviors in normal rats when compared with the control. Among the active compounds identified were gallic acid, ellagic acid, quercetin, and rutin. All the 20 basic amino acids were identified. Given the aforementioned, date and almond could represent a reliable source of functional foods highly rich in compounds with antioxidant activity, and arginase and PDE-5 inhibitory properties. Practical applications Fruits are essential part of the human diet that furnish the body with important nutrients. Despite the crucial roles of fruits in human diets, some fruits like almond and date are underutilized among Nigerians. However, we characterized the important compounds present in these fruits and how their presence contributes to the biological activities of the fruits. Finally, we relate the chemical composition and the observed biological activities to the overall health and wellness of the consumers.
C1 [Adebayo, Adeniyi A.; Oboh, Ganiyu; Ademosun, Ayokunle O.] Fed Univ Technol Akure, Funct Foods & Nutraceut Res Unit, Biochem Dept, PMB 704, Akure 340001, Nigeria.
   [Adebayo, Adeniyi A.] Joseph Ayo Babalola Univ, Chem Sci Dept Biochem Opt, Ikeji Arakeji, Nigeria.
RP Adebayo, AA (corresponding author), Fed Univ Technol Akure, Funct Foods & Nutraceut Res Unit, Biochem Dept, PMB 704, Akure 340001, Nigeria.
EM adeniyiabiodun2@gmail.com
RI Adebayo, Adeniyi/AAW-7178-2020; Oboh, Ganiyu/AAW-5664-2020; Ademosun,
   Ayokunle/O-4299-2019
OI Ademosun, Ayokunle/0000-0001-9767-1844; Adebayo,
   Adeniyi/0000-0002-7428-0119; Oboh, Ganiyu/0000-0001-5167-9779
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NR 75
TC 7
Z9 7
U1 1
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0145-8884
EI 1745-4514
J9 J FOOD BIOCHEM
JI J. Food Biochem.
PD NOV
PY 2022
VL 46
IS 11
SI SI
AR e14255
DI 10.1111/jfbc.14255
EA MAY 2022
PG 12
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA 7A0CD
UT WOS:000802112400001
PM 35644948
DA 2025-06-11
ER

PT J
AU Garcia, JG
   de Miguel, C
   Milagro, FI
   Zalba, G
   Ansorena, E
AF Garcia, Jorge G.
   de Miguel, Carlos
   Milagro, Fermin I.
   Zalba, Guillermo
   Ansorena, Eduardo
TI Endothelial NOX5 Expression Modulates Thermogenesis and Lipolysis in
   Mice Fed with a High-Fat Diet and 3T3-L1 Adipocytes through an
   Interleukin-6 Dependent Mechanism
SO ANTIOXIDANTS
LA English
DT Article
DE obesity; NADPH oxidase 5; thermogenesis; lipolysis; IL-6
ID BROWN ADIPOSE-TISSUE; ACTIVATED PROTEIN-KINASE; OXIDATIVE STRESS;
   INSULIN-RESISTANCE; BODY-TEMPERATURE; ACID OXIDATION; NADPH OXIDASE;
   ADIPONECTIN; ASSOCIATION; METABOLISM
AB Obesity is a global health issue associated with the development of metabolic syndrome, which correlates with insulin resistance, altered lipid homeostasis, and other pathologies. One of the mechanisms involved in the development of these pathologies is the increased production of reactive oxygen species (ROS). One of the main producers of ROS is the family of nicotinamide adenine dinucleotide phosphate (NADPH) oxidases, among which NOX5 is the most recently discovered member. The aim of the present work is to describe the effect of endothelial NOX5 expression on neighboring adipose tissue in obesity conditions by using two systems. An in vivo model based on NOX5 conditional knock-in mice fed with a high-fat diet and an in vitro model developed with 3T3-L1 adipocytes cultured with conditioned media of endothelial NOX5-expressing bEnd.3 cells, previously treated with glucose and palmitic acid. Endothelial NOX5 expression promoted the expression and activation of specific markers of thermogenesis and lipolysis in the mesenteric and epididymal fat of those mice fed with a high-fat diet. Additionally, the activation of these processes was derived from an increase in IL-6 production as a result of NOX5 activity. Accordingly, 3T3-L1 adipocytes treated with conditioned media of endothelial NOX5-expressing cells, presented higher expression of thermogenic and lipolytic genes. Moreover, endothelial NOX5-expressing bEnd.3 cells previously treated with glucose and palmitic acid also showed interleukin (IL-6) production. Finally, it seems that the increase in IL-6 stimulated the activation of markers of thermogenesis and lipolysis through phosphorylation of STAT3 and AMPK, respectively. In conclusion, in response to obesogenic conditions, endothelial NOX5 activity could promote thermogenesis and lipolysis in the adipose tissue by regulating IL-6 production.
C1 [Garcia, Jorge G.; de Miguel, Carlos; Zalba, Guillermo; Ansorena, Eduardo] Univ Navarra, Dept Biochem & Genet, Pamplona 31008, Spain.
   [Garcia, Jorge G.; de Miguel, Carlos; Milagro, Fermin I.; Zalba, Guillermo; Ansorena, Eduardo] Navarra Inst Hlth Res IdiSNA, Pamplona 31008, Spain.
   [Milagro, Fermin I.] Univ Navarra, Dept Nutr Food Sci & Physiol, Ctr Nutr Res, Pamplona 31008, Spain.
   [Milagro, Fermin I.] Inst Salud Carlos III, Ctr Invest Biomed Red Fisiopatol Obesidad & Nutr, Madrid 28029, Spain.
C3 University of Navarra; University of Navarra; University of Navarra;
   Instituto de Salud Carlos III; CIBER - Centro de Investigacion Biomedica
   en Red; CIBEROBN
RP Ansorena, E (corresponding author), Univ Navarra, Dept Biochem & Genet, Pamplona 31008, Spain.; Ansorena, E (corresponding author), Navarra Inst Hlth Res IdiSNA, Pamplona 31008, Spain.
EM jgarcia.51@alumni.unav.es; cdmiguel@unav.es; fmilagro@unav.es;
   gzalba@unav.es; eansorena@unav.es
RI Milagro, Fermin/F-2315-2015; ZALBA, GUILLERMO/AAB-6231-2019; Ansorena,
   Eduardo/AAA-5790-2019; /H-2153-2011
OI Milagro, Fermin I./0000-0002-3228-9916; Ansorena,
   Eduardo/0000-0002-1517-7859; Garcia, Jorge/0000-0003-0925-9441; ZALBA,
   GUILLERMO/0000-0003-4616-1523; /0000-0003-4655-5856
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NR 65
TC 7
Z9 8
U1 1
U2 8
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD JAN
PY 2022
VL 11
IS 1
AR 30
DI 10.3390/antiox11010030
PG 19
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA ZB7JH
UT WOS:000757013600001
PM 35052534
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Li, WJ
   Hu, HB
   Zou, GF
   Ma, ZZ
   Liu, J
   Li, FX
AF Li, Wenjing
   Hu, Hongbo
   Zou, Guofang
   Ma, Zhanzhong
   Liu, Jing
   Li, Fanxiang
TI Therapeutic effects of puerarin on polycystic ovary syndrome A
   randomized trial in Chinese women
SO MEDICINE
LA English
DT Article
DE antioxidant; metabolic disorders; polycystic ovarian syndromes; puerarin
ID HORMONE-BINDING GLOBULIN; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   OXIDATIVE STRESS; GLUCOSE-TOLERANCE; SYNDROME PCOS; MANAGEMENT;
   HYPERANDROGENISM; METAANALYSIS; METFORMIN
AB Background: This study aims to assess the therapeutic effects of a well-known component (puerarin) obtained from a Chinese herb root in patients with polycystic ovary syndrome (PCOS). Methods: Women with premature ovarian failure (POF) were assigned to the obese group (body mass index [BMI] >= 24 kg/m(2) and waist hip ratio [WHR] >0.85) or non-obese group (group 3, n = 21). Obese patients were further randomly assigned to the obese treatment group (group 1, n = 15) and obese control group (group 1, n = 15). All patients received standard treatment (Diane-35, 1 tablet/d, orally, plus metformin, 1.5 g/d, orally). In addition to the standard modality, patients in group 1 and group 3 also orally received 150 mg/d of puerarin tablets for 3 months. Venous blood was drawn before and after treatment. Then, the metabolic and antioxidant biomarkers were measured. The normality of distribution of the data was tested using the Kolmogorov-Smirnov method. The baseline characteristics were analyzed using one-factor analysis of variance (ANOVA), and post-hoc was performed using the least significance difference (LSD)-t test. Results: Significantly improved blood levels of sex hormone binding globulin (SHBG) and superoxide dismutase (SOD) were observed in patients who received the additional treatment of puerarin, regardless of their lean or obese status, while these were not observed in patients who did not receive puerarin. Furthermore, obese patients with PCOS had significantly lower systolic blood pressure, total cholesterol, and testosterone blood levels, when compared with before treatment. Conclusion: The addition of puerarin to the present treatment protocol can be considered for the management of metabolic disorders and hyperandrogenism in PCOS patients.
C1 [Li, Wenjing; Hu, Hongbo; Zou, Guofang; Ma, Zhanzhong; Liu, Jing; Li, Fanxiang] Yuebei Peoples Hosp, Dept Obstet & Gynecol, 133 HuiMinNan Rd, Shaoguan, Guangdong, Peoples R China.
C3 Shantou University
RP Li, WJ (corresponding author), Yuebei Peoples Hosp, Dept Obstet & Gynecol, 133 HuiMinNan Rd, Shaoguan, Guangdong, Peoples R China.
EM maya8301112@163.com
RI Li, Jiarong/ABG-6750-2022; Hu, Hongbo/J-8059-2016; Li,
   Jiaqi/AAF-6183-2019
FU Science and Technology Program of Guangdong Province [2013b021800092];
   Projects for Strengthening Traditional Chinese Medicine from the
   Traditional Chinese Medicine Bureau of Guangdong Province [20151108];
   Guangdong Province Science and Technology Innovation Strategy Project
   [201803011]
FX This project was supported by the Science and Technology Program of
   Guangdong Province (No. 2013b021800092), the Projects for Strengthening
   Traditional Chinese Medicine from the Traditional Chinese Medicine
   Bureau of Guangdong Province (No. 20151108), and the Guangdong Province
   Science and Technology Innovation Strategy Project (No. 201803011).
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NR 47
TC 21
Z9 23
U1 2
U2 24
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD MAY 28
PY 2021
VL 100
IS 21
AR e26049
DI 10.1097/MD.0000000000026049
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA SO8CZ
UT WOS:000659204000041
PM 34032731
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Li, HS
   Sheng, JY
   Wang, J
   Gao, HT
   Yu, J
   Ding, GX
   Ding, N
   He, WQ
   Zha, JM
AF Li, Huashan
   Sheng, Jianying
   Wang, Jing
   Gao, Haiting
   Yu, Jing
   Ding, Guoxian
   Ding, Ning
   He, Weiqi
   Zha, Juanmin
TI Selective Inhibition of 11β-Hydroxysteroid Dehydrogenase Type 1
   Attenuates High-Fat Diet-Induced Hepatic Steatosis in Mice
SO DRUG DESIGN DEVELOPMENT AND THERAPY
LA English
DT Article
DE 11 beta-HSD1; hepatic steatosis; inhibitor; adipose tissue; free fatty
   acids
ID ENDOPLASMIC-RETICULUM STRESS; VISCERAL ADIPOSE-TISSUE;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; LIVER-DISEASE; NONALCOHOLIC
   STEATOHEPATITIS; 11-BETA-HSD1; OBESITY; OVEREXPRESSION; PATHOGENESIS
AB Introduction: The effect of 11 beta-hydroxysteroid dehydrogenase type1 (11 beta-HSD1) inhibition on hepatic steatosis is incompletely understood. Here, we aimed to determine the therapeutic effect of BVT.2733, a selective 11 beta-HSD1 inhibitor, on hepatic steatosis.
   Materials and Methods: C57B/6J mice were randomly divided into a low-fat diet (LFD) fed group and a high-fat diet (HFD) fed group. Mice were fed with HFD for 28 weeks which induced obesity and severe hepatic steatosis. The two groups were further divided into four groups as follows: LFD, LFD with BVT.2733, HFD, and HFD with BVT.2733. Mice in LFD +BVT and HFD+BVT groups were intraperitoneally injected with BVT.2733 daily for 30 days. Effects of BVT.2733 on mice body weight, serum lipid profile, serum free fatty acids (FFAs), glucocorticoid levels, gene expression in adipose and liver tissues were assessed.
   Results: Injection of a low dose of BVT.2733 (50 mg/kg/day) reduced body weight and hyperlipidemia, but did not improve glucose tolerance and insulin resistance in diet-induced obese mice. The low dose of BVT.2733 attenuated hepatic steatosis, liver injury, and liver lipolytic gene expression in diet-induced obese mice. Besides, the low dose of BVT.2733 reduced fat mass and lipolysis in visceral adipose tissues, hepatic FFAs, and serum corticosterone levels in diet-induced obese mice.
   Conclusion: Our study shows that moderate inhibition of 11 beta-HSD1 by BVT.2733 reduces FFAs and corticosterone synthesis in fatty tissues, thereby attenuates the delivery of corticosterone and FFAs to the liver. Collectively, this prevents high-fat diet-induced hepatic steatosis.
C1 [Li, Huashan; Sheng, Jianying; Wang, Jing; Gao, Haiting; Ding, Ning; He, Weiqi; Zha, Juanmin] Soochow Univ, Affiliated Hosp 1, Dept Oncol, Med Coll,Jiangsu Key Lab Neuropsychiat Dis, Suzhou, Peoples R China.
   [Li, Huashan; Sheng, Jianying; Wang, Jing; Gao, Haiting; Ding, Ning; He, Weiqi; Zha, Juanmin] Soochow Univ, Affiliated Hosp 1, Dept Oncol, Med Coll,Cambridge Suda CAM SU Genom Resource Ctr, 199 Ren Ai Rd, Suzhou 205123, Peoples R China.
   [Yu, Jing; Ding, Guoxian] Nanjing Med Univ, Affiliated Hosp 1, Div Geriatr Endocrinol, Dept Geriatr, Nanjing, Peoples R China.
   [He, Weiqi] Nanjing Univ, State Key Lab Pharmaceut Biotechnol, Nanjing, Peoples R China.
C3 Soochow University - China; Soochow University - China; Nanjing Medical
   University; Nanjing University
RP He, WQ; Zha, JM (corresponding author), Soochow Univ, Affiliated Hosp 1, Dept Oncol, Med Coll,Cambridge Suda CAM SU Genom Resource Ctr, 199 Ren Ai Rd, Suzhou 205123, Peoples R China.
EM whe@suda.edu.cn; zhajuanmin@suda.edu.cn
RI He, Weiqi/L-2502-2019; He, Weiqi/I-7935-2013
OI He, Weiqi/0000-0003-3137-8420; Zha, Juanmin/0000-0002-1653-0845
FU Outstanding Youth Foundation of Jiangsu Province [BK20190043]; National
   Natural Science Foundation of China [31971062, 31900326, 81200620];
   Natural Science Foundation of Jiangsu Province [BK20180838]; Natural
   Science Foundation of the Jiangsu Higher Education Institutions of China
   [20KJA180003, 19KJB320003]; Livelihood and Technology Program of Suzhou
   City [SYS2020100, SYS2019030]; Open Fund of State Key Laboratory of
   Pharmaceutical Biotechnology, Nanjing University [KF-GN-202004];
   Research Innovation Program for College Graduates of Jiangsu Province
   [KYCX191981]; International Joint Research Center for Genomic Resources
   [2017B01012]; Tang Scholar of Soochow University
FX Outstanding Youth Foundation of Jiangsu Province (BK20190043), The
   National Natural Science Foundation of China (31971062, 31900326, and
   81200620), The Natural Science Foundation of Jiangsu Province
   (BK20180838), The Natural Science Foundation of the Jiangsu Higher
   Education Institutions of China (20KJA180003, 19KJB320003), The
   Livelihood and Technology Program of Suzhou City (SYS2020100,
   SYS2019030), The Open Fund of State Key Laboratory of Pharmaceutical
   Biotechnology, Nanjing University (KF-GN-202004), and The Research
   Innovation Program for College Graduates of Jiangsu Province
   (KYCX191981). This work is also supported by the International Joint
   Research Center for Genomic Resources (2017B01012) and the Tang Scholar
   of Soochow University.
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NR 52
TC 7
Z9 7
U1 1
U2 11
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1177-8881
J9 DRUG DES DEV THER
JI Drug Des. Dev. Ther.
PY 2021
VL 15
BP 2309
EP 2324
DI 10.2147/DDDT.S285828
PG 16
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA SL3SF
UT WOS:000656838400001
PM 34103895
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Kilany, OE
   Abdelrazek, HMA
   Aldayel, TS
   Abdo, S
   Mahmoud, MMA
AF Kilany, Omnia E.
   Abdelrazek, Heba M. A.
   Aldayel, Tahany Saleh
   Abdo, Shimaa
   Mahmoud, Manal M. A.
TI Anti-obesity potential of Moringa olifera seed extract and
   lycopene on high fat diet induced obesity in male Sprauge Dawely rats
SO SAUDI JOURNAL OF BIOLOGICAL SCIENCES
LA English
DT Article
DE Antioxidants; Inflammatory markers; iNOS; Obesity; Lycopene; Moringa;
   Fatty infiltrations
ID NITRIC-OXIDE SYNTHASE; NECROSIS-FACTOR-ALPHA; INSULIN-RESISTANCE;
   OXIDATIVE STRESS; ENDOTHELIAL DYSFUNCTION; CARDIOVASCULAR-DISEASE;
   METABOLIC SYNDROME; LEPTIN RESISTANCE; TOMATO LYCOPENE; ADIPOSE-TISSUE
AB Present research explored the anti-obesity effect of Moringa olifera seed oil extract and lycopene (LYC). Forty eight male Sprauge Dawely rats were divided equally into 6 groups. Group I (C) served as control, group II (MC) was given Moringa olifera seed oil extract (800 mg/kg b.wt) for 8 weeks, group III (LC) was given (20 mg/kg b.wt) LYC for 8 weeks, group IV (O) received high fat diet (HFD) for 20 weeks, group V (MO), was given HFD for 20 weeks and received (800 mg/kg b.wt) Moringa olifera seed oil extract for last 8 weeks and group VI (LO), received HFD for 20 weeks and was given (20 mg/kg b.wt) LYC for last 8 weeks. Hematology, lipid peroxidation and antioxidants, non-esterified fatty acids (NEFA), glucose, lipid profile, serum liver and kidney biomarkers, inflammatory markers, leptin, resistin and heart fatty acid binding protein (HFABP) were determined. Also histopathology for liver, kidney and aorta were performed besides immunohistochemistry (IHC) for aortic inducible nitric oxide synthase (iNOS). Administration of Moringa olifera seed oil extract and LYC significantly ameliorated the HFD induced hematological and metabolic perturbations as well as reduced leptin and resistin. Both treatments exerted these effects through promotion of antioxidant enzymes and reducing lipid peroxidation as well as inflammatory cytokines along with reduced iNOS protein expression. Administration of Moringa olifera seed oil extract and LYC have anti-obesity potential in HFD induced obesity in male Sprauge Dawely rats. (C) 2020 The Author(s). Published by Elsevier B.V. on behalf of King Saud University.
C1 [Kilany, Omnia E.] Suez Canal Univ, Fac Vet Med, Dept Clin Pathol, Ismailia, Egypt.
   [Abdelrazek, Heba M. A.] Suez Canal Univ, Fac Vet Med, Dept Physiol, Ismailia, Egypt.
   [Aldayel, Tahany Saleh] Princess Nourah Bint Abdulrahman Univ, Dept Phys Sport Sci, Nutr & Food Sci, Riyadh, Saudi Arabia.
   [Abdo, Shimaa] Suez Canal Author Hosp, Ismailia, Egypt.
   [Mahmoud, Manal M. A.] Suez Canal Univ, Fac Vet Med, Nutr & Clin Nutr Dept, Ismailia, Egypt.
C3 Egyptian Knowledge Bank (EKB); Suez Canal University; Egyptian Knowledge
   Bank (EKB); Suez Canal University; Princess Nourah bint Abdulrahman
   University; Egyptian Knowledge Bank (EKB); Suez Canal University;
   Egyptian Knowledge Bank (EKB); Suez Canal University
RP Aldayel, TS (corresponding author), Princess Nourah Bint Abdulrahman Univ, Dept Phys Sport Sci, Nutr & Food Sci, Riyadh, Saudi Arabia.
EM TSALdayel@pnu.edu.sa
RI Aldayel, Tahany/HII-2738-2022; mahmoud, manal/HCI-1901-2022; Stefanadis,
   Christodoulos/ABH-2232-2020
OI Abdelrazek, Heba/0000-0001-8906-7970; Stefanadis,
   Christodoulos/0000-0001-5974-6454
FU Deanship of Scientific Research at Princess Nourah bint Abdulrahman
   University through the fasttrack Research Funding Program
FX This research was funded by the Deanship of Scientific Research at
   Princess Nourah bint Abdulrahman University through the fasttrack
   Research Funding Program.
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NR 163
TC 37
Z9 38
U1 1
U2 14
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1319-562X
EI 2213-7106
J9 SAUDI J BIOL SCI
JI Saudi J. Biol. Sci.
PD OCT
PY 2020
VL 27
IS 10
BP 2733
EP 2746
DI 10.1016/j.sjbs.2020.06.026
PG 14
WC Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics
GA NQ6JT
UT WOS:000570978100004
PM 32994733
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Jahrami, HA
   Alsibai, J
   Clark, CCT
   Faris, MAIE
AF Jahrami, Haitham A.
   Alsibai, Joud
   Clark, Cain C. T.
   Faris, Mo'ez Al-Islam E.
TI A systematic review, meta-analysis, and meta-regression of the impact of
   diurnal intermittent fasting during Ramadan on body weight in healthy
   subjects aged 16 years and above
SO EUROPEAN JOURNAL OF NUTRITION
LA English
DT Review
DE Body weight; Caloric restriction; Diurnal intermittent fasting;
   Meta-analysis; Obesity; Ramadan; Systematic review
ID DISEASE RISK MARKERS; HEMATOLOGICAL PARAMETERS; METABOLIC SYNDROME;
   PHYSICAL-ACTIVITY; BLOOD-PRESSURE; LIPID PROFILE; BIOCHEMICAL
   PARAMETERS; ENERGY RESTRICTION; ACTIVITY PATTERNS; OXIDATIVE STRESS
AB Purpose Studies on the effect of Ramadan diurnal intermittent fasting (RDIF) on body weight have yielded conflicting results. Therefore, we conducted a systematic review and meta-analysis to estimate the effect size of body weight changes in healthy, non-athletic Muslims practicing Ramadan fasting, and to assess the effect of covariates such as age, sex, fasting time duration, season, and country, using subgroup analysis, and meta-regression. Covariate adjustments were performed to explain the variability of weight change in response to Ramadan fasting. Methods CINAHL, Cochrane, EBSCOhost, EMBASE, Google Scholar, ProQuest Medical, PubMed/MEDLINE, ScienceDirect, Scopus, and Web of Science databases were searched from date of inception in 1950 to the end of August 2019. Results Eighty-five studies, conducted in 25 countries during 1982-2019, were identified. RDIF yielded a significant, but small reduction in body weight (K = 85, number of subjects,N = 4176 (aged 16-80 years), Hedges' g =- 0.360, 95% confidence interval (CI) - 0.405 to - 0.315,I-2 = 45.6%), this effect size translates into difference in means of - 1.022 kg (95% CI - 1.164 kg to - 0.880 kg). Regression analysis for moderator covariates revealed that fasting time (min/day) is a significant (P < 0.05) moderator for weight change at the end of Ramadan, while age and sex are not. Variable effects for the season and country were found. Conclusion RDIF may confer a significant small reduction in body weight in non-athletic healthy people aged 16 years and above, directly associated with fasting time and variably correlated with the season, and country.
C1 [Jahrami, Haitham A.] Minist Hlth, Periphery Hosp, Rehabil Serv, Manama, Bahrain.
   [Jahrami, Haitham A.] Arabian Gulf Univ, Coll Med & Med Sci, Manama, Bahrain.
   [Alsibai, Joud; Faris, Mo'ez Al-Islam E.] Univ Sharjah, Res Inst Med & Hlth Sci RIMHS, Dept Clin Nutr & Dietet, Coll Hlth Sci, POB 27272, Sharjah, U Arab Emirates.
   [Clark, Cain C. T.] Coventry Univ, Ctr Sport Exercise & Life Sci, Coventry, W Midlands, England.
C3 Ministry of Health - Bahrain; Arabian Gulf University; University of
   Sharjah; Coventry University
RP Faris, MAIE (corresponding author), Univ Sharjah, Res Inst Med & Hlth Sci RIMHS, Dept Clin Nutr & Dietet, Coll Hlth Sci, POB 27272, Sharjah, U Arab Emirates.
EM mfaris@sharjah.ac.ae
RI Jahrami, Haitham/JVO-6632-2024; Clark, Cain/I-4480-2019; Faris,
   MoezAlIslam/M-9682-2017
OI Clark, Dr. Cain/0000-0002-6610-4617; Faris,
   MoezAlIslam/0000-0002-7970-2616; Jahrami, Haitham/0000-0001-8990-1320
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NR 161
TC 81
Z9 81
U1 1
U2 14
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1436-6207
EI 1436-6215
J9 EUR J NUTR
JI Eur. J. Nutr.
PD SEP
PY 2020
VL 59
IS 6
BP 2291
EP 2316
DI 10.1007/s00394-020-02216-1
PG 26
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA MW4ND
UT WOS:000557014800002
PM 32157368
DA 2025-06-11
ER

PT J
AU Concistrè, A
   Petramala, L
   Bisogni, V
   Mezzadri, M
   Olmati, F
   Saracino, V
   Oliviero, G
   Bonvicini, M
   Tonnarini, G
   Iannucci, G
   Letizia, C
AF Concistre, Antonio
   Petramala, Luigi
   Bisogni, Valeria
   Mezzadri, Martina
   Olmati, Federica
   Saracino, Vincenza
   Oliviero, Gaia
   Bonvicini, Maria
   Tonnarini, Gianfranco
   Iannucci, Gino
   Letizia, Claudio
TI Subclinical atherosclerosis due to increase of plasma aldosterone
   concentrations in essential hypertensive individuals
SO JOURNAL OF HYPERTENSION
LA English
DT Article
DE aldosterone; essential hypertension; hyperuricemia; subclinical
   atherosclerosis
ID INTIMA-MEDIA THICKNESS; CARDIOVASCULAR-DISEASE MORTALITY; METABOLIC
   SYNDROME; OXIDATIVE STRESS; RENIN RATIO; MICROALBUMINURIA; INDEX;
   ASSOCIATION; EPLERENONE; FIBROSIS
AB Background and aims: The adrenal mineralocorticoid system plays a key role in cardiovascular, metabolic and renal damage. This study aimed to assess the relationship between plasma aldosterone concentration (PAC) and some surrogate markers of subclinical atherosclerosis, such as carotid intima-media thickness (cIMT), ankle-brachial index (ABI) and biochemical parameters in patients with essential hypertension.
   Methods and results: From January 2014 to December 2017, we consecutively enrolled 804 essential hypertensive patients (407 men and 397 women, mean age 50 +/- 14 years) without cardiovascular complications, distinguishing patients in quartiles according to PAC. Compared with the first quartile, the highest PAC quartile was associated with the highest levels of serum uric acid (SUA) (5.3 +/- 1.3 vs. 5.0 +/- 1.0mg/dl; P = 0.01), triglycerides (117.5 +/- 15.7 vs. 106.8 +/- 10.5mg/dl; P<0.05), 24-h urinary albumin excretion (UAE) (38.8 +/- vs. 7.6 +/- mg/24 h; P<0.05), cIMT (0.87 +/- 0.22 vs. 0.80 +/- 0.21 mm; P = 0.001) and increased prevalence of carotid plaques (26 vs. 16%; P<0.005). Moreover, we found that in patients with PAC more than 150 pg/ml, the ABI was significantly lower than those with PAC<150 pg/ml (1.01 +/- 0.09 vs. 1.10 +/- 0.09; P<0.022). PAC was also found to be an independent predictor of the presence of carotid plaques and pathological ABI (<0.9) in essential hypertensive individuals.
   Conclusion: Our results revealed that higher PAC values are strongly associated with some metabolic variables, as triglycerides, UAE, cIMT, worse ABI and major prevalence of carotid plaques that, together with elevated blood pressure values, are strictly correlated with higher risk of atherosclerosis and cardiovascular complications.
C1 [Concistre, Antonio; Petramala, Luigi; Bisogni, Valeria; Mezzadri, Martina; Olmati, Federica; Saracino, Vincenza; Oliviero, Gaia; Bonvicini, Maria; Tonnarini, Gianfranco; Iannucci, Gino; Letizia, Claudio] Univ Rome Sapienza, Secondary Hypertens Unit, Dept Translat & Precis Med, Rome, Italy.
C3 Sapienza University Rome
RP Letizia, C (corresponding author), Azienda Univ Policlin Umberto I, Dept Translat & Precis Med, Viale Policlin 155, I-00155 Rome, Italy.
EM claudio.letizia@uniroma1.it
RI Iannucci, Gino/W-9210-2019; Concistrè, Antonio/CAH-1508-2022
OI Saracino, Vincenza/0000-0002-6491-8780; Concistre,
   Antonio/0000-0001-5952-1853; IANNUCCI, GINO/0000-0003-3055-965X
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NR 44
TC 13
Z9 13
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0263-6352
EI 1473-5598
J9 J HYPERTENS
JI J. Hypertens.
PD NOV
PY 2019
VL 37
IS 11
BP 2232
EP 2239
DI 10.1097/HJH.0000000000002170
PG 8
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA KF8HP
UT WOS:000509478200016
PM 31205201
DA 2025-06-11
ER

PT J
AU Iranshahy, M
   Javadi, B
   Iranshahi, M
   Jahanbakhsh, SP
   Mahyari, S
   Hassani, FV
   Karimi, G
AF Iranshahy, Milad
   Javadi, Behjat
   Iranshahi, Mehrdad
   Jahanbakhsh, Seyedeh Pardis
   Mahyari, Saman
   Hassani, Faezeh Vandati
   Karimi, Gholamreza
TI A review of traditional uses, phytochemistry and pharmacology of
   Portulaca oleracea L
SO JOURNAL OF ETHNOPHARMACOLOGY
LA English
DT Review
DE Portulaca oleracea L.; Ethnopharmacology; Anti-hyperlipidemic;
   Anti-hyperglycemic; Hepatoprotective; Renoprotective
ID MUSCLE RELAXANT ACTION; MEDICINAL-PLANTS; ETHNOBOTANICAL SURVEY; AQUEOUS
   EXTRACT; MONOTERPENE GLUCOSIDE; ETHANOLIC EXTRACTS; DIABETES-MELLITUS;
   OXIDATIVE STRESS; POTASSIUM-IONS; CLINICAL-TRIAL
AB Ethnopharmacological relevance: Portulaca oleracea L. is a widespread medicinal plant that is used not only as an edible plant, but also as a traditional medicine for alleviating a wide spectrum of diseases. It is a well-known plant in the European Traditional Medicine. PA is mentioned by Dioscorides (40-90 CE), with the name of "andrachne".
   Aim of the review: In this study, we provide detailed information on botany, traditional uses, phytochemistry, pharmacological uses, pharmacokinetics and safety of P. oleracea.
   Materials and methods: An extensive search on electronic databases including PubMed, Web of Science, Google Scholar, ScienceDirect, Scopus, conference papers, local herbal encyclopedias, articles, books (in English, French, Arabic, Persian, etc.) and also a number of unpublished handwritten manuscripts was done to find articles have been published between 1956 and 2015 on pharmacology and phytochemistry of P. oleracea.
   Results: P. oleracea has been addressed in De Materia Medico as an astringent, and a remedy for headaches, inflammation of the eyes and other organs, burning of the stomach, erysipela, disorders of the bladder, numbness of the teeth, excessive sexual desire, burning fevers, worms, dysentery, hemorrhoids, eruptions of blood, and bites. Phytochemical investigations revealed that this plant a wide range of secondary metabolites including alkaloids, terpenoids, flavonoids and organic acids. The most important pharmacological activities are renoprotective activities and effects on metabolism. P. oleracea could successfully decrease blood glucose and lipid profile of patients with metabolic syndrome. The safety of P. oleracea has been reported in many clinical trials.
   Conclusion: Modern pharmacological studies have now proven many traditional uses of P. oleracea, including anti-hyperglycemic and anti-hyperlipidemic, renoprotective and hepatoprotective effects. In addition, in many clinical trials P. oleracea showed no adverse effects and constipation was reported as the most frequent adverse effect.
C1 [Iranshahy, Milad; Iranshahi, Mehrdad] Mashhad Univ Med Sci, Biotechnol Res Ctr, Mashhad, Iran.
   [Iranshahy, Milad; Iranshahi, Mehrdad] Mashhad Univ Med Sci, Sch Pharm, Mashhad, Iran.
   [Javadi, Behjat] Mashhad Univ Med Sci, Sch Pharm, Dept Tradit Pharm, Mashhad, Iran.
   [Jahanbakhsh, Seyedeh Pardis; Mahyari, Saman] Mashhad Univ Med Sci, Sch Pharm, Pharmaceut Res Ctr, Dept Clin Pharm, Mashhad, Iran.
   [Hassani, Faezeh Vandati; Karimi, Gholamreza] Mashhad Univ Med Sci, Sch Pharm, Pharmaceut Res Ctr, POB 91775-1365, Mashhad, Iran.
C3 Mashhad University of Medical Sciences; Mashhad University of Medical
   Sciences; Mashhad University of Medical Sciences; Mashhad University of
   Medical Sciences; Mashhad University of Medical Sciences
RP Karimi, G (corresponding author), Mashhad Univ Med Sci, Sch Pharm, Pharmaceut Res Ctr, POB 91775-1365, Mashhad, Iran.
EM KarimiG@mums.ac.ir
RI Iranshahi, Mehrdad/E-3664-2014; Javadi, Behjat/AAC-5468-2020; Iranshahy,
   milad/AAC-2539-2019; Karimi, Gholamreza/AAD-6369-2019
OI , Milad/0000-0002-5339-6294; Javadi, Behjat/0000-0002-8512-3215
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NR 140
TC 178
Z9 192
U1 5
U2 85
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0378-8741
J9 J ETHNOPHARMACOL
JI J. Ethnopharmacol.
PD JUN 9
PY 2017
VL 205
BP 158
EP 172
DI 10.1016/j.jep.2017.05.004
PG 15
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA EZ4SX
UT WOS:000404703900015
PM 28495602
DA 2025-06-11
ER

PT J
AU Martínez-Micaelo, N
   González-Abuín, N
   Terra, X
   Ardévol, A
   Pinent, M
   Petretto, E
   Behmoaras, J
   Blay, M
AF Martinez-Micaelo, Neus
   Gonzalez-Abuin, Noemi
   Terra, Ximena
   Ardevol, Ana
   Pinent, Montserrat
   Petretto, Enrico
   Behmoaras, Jacques
   Blay, Mayte
TI Identification of a nutrient-sensing transcriptional network in
   monocytes by using inbred rat models on a cafeteria diet
SO DISEASE MODELS & MECHANISMS
LA English
DT Article
DE Cafeteria diet; Inbred rats; Monocyte transcriptome; LEW; WKY
ID GENE-EXPRESSION; MOLECULAR CHARACTERIZATION; GLOMERULONEPHRITIS;
   METABOLISM; ALGORITHM; FRAMEWORK; LINKING; OBESITY; LEPTIN
AB Obesity has reached pandemic levels worldwide. The current models of diet-induced obesity in rodents use predominantly high-fat based diets that do not take into account the consumption of variety of highly palatable, energy-dense foods that are prevalent in Western society. We and others have shown that the cafeteria (CAF) diet is a robust and reproducible model of human metabolic syndrome with tissue inflammation in the rat. We have previously shown that inbred rat strains such as Wistar Kyoto (WKY) and Lewis (LEW) show different susceptibilities to CAF diets with distinct metabolic and morphometric profiles. Here, we show a difference in plasma MCP-1 levels and investigate the effect of the CAF diet on peripheral blood monocyte transcriptome, as powerful stress-sensing immune cells, in WKY and LEWrats. We found that 75.5% of the differentially expressed transcripts under the CAF diet were upregulated in WKY rats and were functionally related to the activation of the immune response. Using a gene co-expression network constructed from the genes differentially expressed between CAF diet-fed LEW and WKY rats, we identified acyl-CoA synthetase short-chain family member 2 (Acss2) as a hub gene for a nutrient-sensing cluster of transcripts in monocytes. The Acss2genomic region is significantly enriched for previously established metabolism quantitative trait loci in the rat. Notably, monocyte expression levels of Acss2 significantly correlated with plasma glucose, triglyceride, leptin and non-esterified fatty acid (NEFA) levels as well as morphometric measurements such as body weight and the total fat following feeding with the CAF diet in the rat. These results show the importance of the genetic background innutritional genomics and identify inbred rat strains as potential models for CAF-diet-induced obesity.
C1 [Martinez-Micaelo, Neus; Gonzalez-Abuin, Noemi; Terra, Ximena; Ardevol, Ana; Pinent, Montserrat; Blay, Mayte] Univ Rovira & Virgili, Dept Biochem & Biotechnol, Mobiofood Res Grp, Tarragona 43003, Spain.
   [Petretto, Enrico] Imperial Coll London, Hammersmith Hosp, MRC Clin Sci Ctr, Du Cane Rd, London W12 0NN, England.
   [Petretto, Enrico] Duke NUS Grad Med Sch Singapore, 8 Coll Rd, Singapore 169857, Singapore.
   [Behmoaras, Jacques] Imperial Coll London, Ctr Complement & Inflammat Res, Du Cane Rd, London W12 0NN, England.
C3 Universitat Rovira i Virgili; Imperial College London; National
   University of Singapore; Imperial College London
RP Blay, M (corresponding author), Univ Rovira & Virgili, Dept Biochem & Biotechnol, Mobiofood Res Grp, Tarragona 43003, Spain.; Behmoaras, J (corresponding author), Imperial Coll London, Ctr Complement & Inflammat Res, Du Cane Rd, London W12 0NN, England.
EM Jacques.behmoaras@imperial.ac.uk; mteresa.blay@urv.cat
RI Ardévol, Anna/AAO-6194-2021; Pinent, Montserrat/ABE-6178-2021; Blay, M.
   Teresa/B-1680-2009; Terra, Ximena/K-3918-2014
OI Gonzalez-Abuin, Noemi/0000-0001-5484-1604; Blay, M.
   Teresa/0000-0002-6256-9847; Martinez-Micaelo, Neus/0000-0001-6101-2847;
   Behmoaras, Jacques/0000-0002-5170-2606; Terra,
   Ximena/0000-0003-1043-5844; Petretto, Enrico/0000-0003-2163-5921;
   Ardevol, Anna/0000-0003-0156-7538
FU Ministerio de Economia y Competitividad of the Spanish Government
   [AGL2014-55347R]; Medical Research Council [MR/M004716/1, MR/N01121X/1];
   Universitat Rovira i Virgili; mobility grant from the Ministerio de
   Educacion, Cultura y Deporte of the Spanish Government; MRC
   [MR/N01121X/1, MR/M004716/1, MC_U120097112] Funding Source: UKRI
FX This study was supported from the Ministerio de Economia y
   Competitividad of the Spanish Government [grant number AGL2014-55347R].
   J.B. and E.P. acknowledges funding from the Medical Research Council
   [grant number MR/M004716/1]. J.B. acknowledges funding from Medical
   Research Council [grant number MR/N01121X/1]. N.M-M. holds a PhD grant
   from the Universitat Rovira i Virgili and mobility grant from the
   Ministerio de Educacion, Cultura y Deporte of the Spanish Government.
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NR 34
TC 11
Z9 11
U1 0
U2 7
PU COMPANY BIOLOGISTS LTD
PI CAMBRIDGE
PA BIDDER BUILDING, STATION RD, HISTON, CAMBRIDGE CB24 9LF, ENGLAND
SN 1754-8403
EI 1754-8411
J9 DIS MODEL MECH
JI Dis. Model. Mech.
PD OCT 1
PY 2016
VL 9
IS 10
BP 1231
EP 1239
DI 10.1242/dmm.025528
PG 9
WC Cell Biology; Medicine, Research & Experimental; Pathology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Research & Experimental Medicine; Pathology
GA EB7OX
UT WOS:000387579100017
PM 27483348
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Inci, R
   Ozturk, P
   Inci, MF
   Mulayim, MK
   Ozdemir, MM
   Zorlu, A
AF Inci, Rahime
   Ozturk, Perihan
   Inci, Mehmet Fatih
   Mulayim, Mehmet Kamil
   Ozdemir, Mine Mujde
   Zorlu, Ali
TI Carotid intima-media thickness, nonalcoholic fatty liver disease, and
   hemoglobin A1c are independently associated with the severity of
   psoriasis
SO DERMATOLOGICA SINICA
LA English
DT Article
DE atherosclerosis; cardiovascular risk; carotid artery intima-media
   thickness; nonalcoholic fatty liver disease; psoriasis
ID BODY-MASS INDEX; CARDIOVASCULAR RISK-FACTORS; METABOLIC SYNDROME;
   ENDOTHELIAL FUNCTION; INFLAMMATION; PREVALENCE; ATHEROSCLEROSIS; STRESS;
   PLAQUE
AB Background: Systemic inflammation plays an important role in the pathogenesis of atherosclerosis in psoriasis patients. Carotid artery intima-media thickness (CIMT) and nonalcoholic fatty liver disease (NAFLD) are accepted important markers for subclinical atherosclerosis and cardiovascular risk prediction.
   Objectives: The aim of this study was to evaluate the potential association between subclinical atherosclerosis and chronic plaque psoriasis without traditional cardiovascular risk factors.
   Methods: Sixty consecutive patients with chronic plaque psoriasis (patient group) attending our dermatology outpatient clinic and 60 age-and sex-matched healthy controls (control group) were included in this study. Demographic and biochemical data, and Psoriasis Area and Severity Index (PASI) score of the psoriasis group were recorded. CIMT and NAFLD values were compared.
   Results: Patients with psoriasis had significantly higher systolic and diastolic blood pressure, fasting levels of glucose, and hemoglobin A1c (HbA1c) compared with controls. Patients with psoriasis had greater CIMT and NAFLD values than matched controls. PASI score was significantly positively correlated with systolic and diastolic blood pressure, body mass index, waist circumference, psoriasis duration, HbA1c, the presence of NAFLD, moderate-severe NAFLD, and CIMT in psoriatic patients. In multivariate linear regression analysis, HbA1c, moderate-severe NAFLD, and CIMT were significantly and independently associated with PASI score, and CIMT showed the most significant association with PASI score.
   Conclusion: Our data suggest a need for aggressive treatment of the inflammatory process in psoriatic patients as well as better monitoring of nontraditional atherosclerotic risk factors to reduce cardiovascular mortality/morbidity and liver diseases. Abdominal and carotid ultrasonography appear to be useful, simple, and noninvasive examinations to investigate the presence of subclinical atherosclerosis even in psoriatic patients who seem to be otherwise healthy. Copyright (C) 2016, Taiwanese Dermatological Association. Published by Elsevier Taiwan LLC.
C1 [Inci, Rahime] Izmir Katip Celebi Univ, Ataturk Training & Res Hosp, Dept Dermatol, Izmir, Turkey.
   [Ozturk, Perihan; Mulayim, Mehmet Kamil; Ozdemir, Mine Mujde] Sutcu Imam Univ, Sch Med, Dept Dermatol, Kahramanmaras, Turkey.
   [Inci, Mehmet Fatih] Izmir Katip Celebi Univ, Sch Med, Dept Radiol, Izmir, Turkey.
   [Zorlu, Ali] Cumhuriyet Univ, Sch Med, Dept Cardiol, Sivas, Turkey.
C3 Izmir Ataturk Training & Research Hospital; Izmir Katip Celebi
   University; Kahramanmaras Sutcu Imam University; Izmir Katip Celebi
   University; Cumhuriyet University
RP Inci, R (corresponding author), Izmir Katip Celebi Univ, Dept Dermatol, Ataturk Egitim & Arastirma Hastanesi, Dermatoloji AD, TR-35360 Izmir, Turkey.
EM drrahimeinci@gmail.com
RI Inci, Rahime/IVH-1974-2023; Kuş, Mine/JOK-1071-2023
CR [Anonymous], ACTA DERMATOVENEROL
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NR 42
TC 4
Z9 4
U1 2
U2 2
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, Maharashtra, INDIA
SN 1027-8117
EI 2223-330X
J9 DERMATOL SIN
JI Dermatol. Sin.
PD SEP
PY 2016
VL 34
IS 3
BP 135
EP 140
DI 10.1016/j.dsi.2016.03.004
PG 6
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA DU6IX
UT WOS:000382319100004
OA gold
DA 2025-06-11
ER

PT J
AU Harrell, JW
   Johansson, RE
   Evans, TD
   Sebranek, JJ
   Walker, BJ
   Eldridge, MW
   Serlin, RC
   Schrage, WG
AF Harrell, John W.
   Johansson, Rebecca E.
   Evans, Trent D.
   Sebranek, Joshua J.
   Walker, Benjamin J.
   Eldridge, Marlowe W.
   Serlin, Ronald C.
   Schrage, William G.
TI Preserved Microvascular Endothelial Function in Young, Obese Adults with
   Functional Loss of Nitric Oxide Signaling
SO FRONTIERS IN PHYSIOLOGY
LA English
DT Article
DE obesity; microcirculation; endothelium; nitric oxide synthase; vascular
   function
ID SKELETAL-MUSCLE VASODILATION; FACTOR-KAPPA-B; OXIDATIVE STRESS;
   DEPENDENT VASODILATION; HYPERPOLARIZING FACTOR; METABOLIC SYNDROME;
   HYDROGEN-PEROXIDE; EXERCISE HYPEREMIA; INSULIN-RESISTANCE; BLOOD-FLOW
AB Data indicate endothelium-dependent dilation (EDD) may be preserved in the skeletal muscle microcirculation of young, obese adults. Preserved EDD might be mediated by compensatory mechanisms, impeding insight into preclinical vascular dysfunction. We aimed to determine the functional roles of nitric oxide synthase (NOS) and cyclooxygenase (COX) toward EDD in younger obese adults. We first hypothesized EDD would be preserved in young, obese adults. Further, we hypothesized a reduced contribution of NOS in young, obese adults would be replaced by increased COX signaling. Microvascular EDD was assessed with Doppler ultrasound and brachial artery infusion of acetylcholine (ACh) in younger (27 +/- 1 year) obese (n = 29) and lean (n = 46) humans. Individual and combined contributions of NOS and COX were examined with intra-arterial infusions of L-NMMA and ketorolac, respectively. Vasodilation was quantified as an increase in forearm vascular conductance (Delta FVC). Arterial endothelial cell biopsies were analyzed for protein expression of endothelial nitric oxide synthase (eNOS). Delta FVC to ACh was similar between groups. After L-NMMA, Delta FVC to ACh was greater in obese adults (p < 0.05). There were no group differences in Delta FVC to ACh with ketorolac. With combined NOS-COX inhibition, Delta FVC was greater in obese adults at the intermediate dose of ACh. Surprisingly, arterial endothelial cell eNOS and phosphorylated eNOS were similar between groups. Younger obese adults exhibit preserved EDD and eNOS expression despite functional dissociation of NOS mediated vasodilation and similar COX signaling. Compensatory NOS- and COX-independent vasodilatory mechanisms conceal reduced NOS contributions in otherwise healthy obese adults early in life, which may contribute to vascular dysfunction.
C1 [Harrell, John W.; Johansson, Rebecca E.; Evans, Trent D.; Schrage, William G.] Univ Wisconsin, Dept Kinesiol, Bruno Balke Biodynam Lab, Madison, WI 53706 USA.
   [Sebranek, Joshua J.; Walker, Benjamin J.] Univ Wisconsin, Univ Wisconsin Hosp & Clin, Dept Anesthesiol, Madison, WI USA.
   [Eldridge, Marlowe W.] Univ Wisconsin, Sch Med & Publ Hlth, Dept Populat Hlth Sci, John Rankin Lab Pulm Med, Madison, WI USA.
   [Eldridge, Marlowe W.] Univ Wisconsin, Univ Wisconsin Hosp & Clin, Dept Pediat, Madison, WI USA.
   [Serlin, Ronald C.] Univ Wisconsin, Dept Educ Psychol, Madison, WI 53706 USA.
C3 University of Wisconsin System; University of Wisconsin Madison;
   University of Wisconsin System; University of Wisconsin Madison;
   University Wisconsin Madison Hospital; University of Wisconsin System;
   University of Wisconsin Madison; University of Wisconsin System;
   University of Wisconsin Madison; University Wisconsin Madison Hospital;
   University of Wisconsin System; University of Wisconsin Madison
RP Schrage, WG (corresponding author), Univ Wisconsin, Dept Kinesiol, Bruno Balke Biodynam Lab, Madison, WI 53706 USA.
EM wschrage@wisc.edu
OI Johansson, Rebecca/0000-0002-0605-1293
FU NIH [HL105820]; Clinical and Translational Science Award program through
   the NIH National Center for Advancing Translational Sciences
   [UL1TR000427]
FX Studies were supported by the NIH [HL105820]. Support was provided by
   the Clinical and Translational Science Award program through the NIH
   National Center for Advancing Translational Sciences [UL1TR000427]
   (insulin assay).
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NR 46
TC 7
Z9 8
U1 0
U2 8
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-042X
J9 FRONT PHYSIOL
JI Front. Physiol.
PD DEC 22
PY 2015
VL 6
AR 387
DI 10.3389/fphys.2015.00387
PG 10
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA CZ1US
UT WOS:000366891700001
PM 26733880
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Akrivos, J
   Ravona-Springer, R
   Schmeidler, J
   LeRoith, D
   Heymann, A
   Preiss, R
   Hoffman, H
   Koifman, K
   Silverman, JM
   Beeri, MS
AF Akrivos, Jimmy
   Ravona-Springer, Ramit
   Schmeidler, James
   LeRoith, Derek
   Heymann, Anthony
   Preiss, Rachel
   Hoffman, Hadas
   Koifman, Keren
   Silverman, Jeremy M.
   Beeri, Michal Schnaider
TI Glycemic control, inflammation, and cognitive function in older patients
   with type 2 diabetes
SO INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
LA English
DT Article
DE HbA1c; C-reactive protein; cognitive function; type 2 diabetes; older
   people
ID C-REACTIVE PROTEIN; ACUTE GLUCOSE FLUCTUATIONS; METABOLIC SYNDROME;
   ALZHEIMERS-DISEASE; OXIDATIVE STRESS; FOLLOW-UP; DECLINE; RISK;
   PERFORMANCE; INDIVIDUALS
AB Objective: Glycated hemoglobin (HbA1c) and C-reactive protein (CRP) have been associated with cognitive impairment independently. However, it is unclear if their combination exacerbates poor cognitive function. We assessed whether long-term glycemic level and glycemic variability modulate the association of systemic inflammation with cognitive function, in a sample of cognitively normal older people with type 2 diabetes.
   Methods: A retrospective cohort study of 777 randomly selected participants from similar to 11,000 patients in the Maccabi Healthcare Services Diabetes Registry, as part of the Israel Diabetes and Cognitive Decline study. Subjects averaged 18 (+/-9.4) HbA1c measures in the Maccabi Healthcare Services Registry, which were used to calculate long-term glycemic level (HbA1c-mean) and glycemic variability (HbA1c-standard deviation (SD)). Linear regression models assessed the interactions of CRP, a marker of systemic inflammation, with HbA1c-mean and HbA1c-SD on subjects' performance in tests of Memory, Executive Functions, Attention, and Semantic Categorization.
   Results: Quadratic interactions of CRP with HbA1c-SD approached significance for executive functions and overall cognition. However, after Bonferroni adjustment, none of the interactions of CRP with HbA1c were statistically significant. In partial correlations according to HbA1c-SD tertiles, CRP was weakly correlated in the middle tertile with decreased performance in the domains of semantic categorization (r= -0.166, p=0.011), executive functions (r=-0.136, p=0.038), and overall cognition (r= -0.157, p=0.016).
   Conclusions: Glycated hemoglobin does not substantially modulate the association of CRP with cognition in a sample of cognitively normal, community dwelling older people with relatively well-managed type 2 diabetes. Copyright (C) 2015 John Wiley & Sons, Ltd.
C1 [Akrivos, Jimmy; Schmeidler, James; Silverman, Jeremy M.; Beeri, Michal Schnaider] Icahn Sch Med Mt Sinai, Dept Psychiat, New York, NY 10029 USA.
   [Akrivos, Jimmy; Silverman, Jeremy M.] James J Peters Vet Affairs Med Ctr, Bronx, NY USA.
   [Ravona-Springer, Ramit; Koifman, Keren; Beeri, Michal Schnaider] Sheba Med Ctr, Joseph Sagol Neurosci Ctr, Ramat Gan, Israel.
   [LeRoith, Derek] Icahn Sch Med Mt Sinai, Dept Med, New York, NY 10029 USA.
   [LeRoith, Derek] Rambam Med Ctr, Haifa, Israel.
   [Heymann, Anthony; Preiss, Rachel; Hoffman, Hadas] Maccabi Healthcare Serv, Tel Aviv, Israel.
   [Beeri, Michal Schnaider] IDC Herzliya, Herzliyya, Israel.
C3 Icahn School of Medicine at Mount Sinai; US Department of Veterans
   Affairs; Veterans Health Administration (VHA); James J. Peters VA
   Medical Center; Chaim Sheba Medical Center; Tel Aviv University; Icahn
   School of Medicine at Mount Sinai; Rambam Health Care Campus; Reichman
   University
RP Akrivos, J (corresponding author), Icahn Sch Med Mt Sinai, Dept Psychiat, New York, NY 10029 USA.
EM Jimmy.Akrivos@mssm.edu
RI Silverman, Jeremy/AAO-4268-2020
OI heymann, anthony/0000-0003-2353-9933
FU NIA [R01 AG034087]; Leroy Schecter Foundation; Helen Bader Foundation;
   Irma T. Hirschl Scholar award; American Federation for Aging Research
   (AFAR); Alzheimer's Association [NIRG-11-205083]
FX This study was supported by NIA grant R01 AG034087 to Dr. Beeri, the
   Leroy Schecter Foundation, the Helen Bader Foundation, and the Irma T.
   Hirschl Scholar award to Dr. Beeri, the American Federation for Aging
   Research (AFAR) Young Investigator award, and the Alzheimer's
   Association grant NIRG-11-205083 to Dr. Ravona-Springer.
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NR 30
TC 14
Z9 19
U1 0
U2 11
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0885-6230
EI 1099-1166
J9 INT J GERIATR PSYCH
JI Int. J. Geriatr. Psychiatr.
PD OCT
PY 2015
VL 30
IS 10
BP 1093
EP 1100
DI 10.1002/gps.4267
PG 8
WC Geriatrics & Gerontology; Gerontology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Psychiatry
GA CU7OB
UT WOS:000363729700012
PM 25703191
OA Green Accepted
DA 2025-06-11
ER

PT J
AU von Bibra, H
   Paulus, WJ
   Sutton, MSJ
   Leclerque, C
   Schuster, T
   Schumm-Draeger, PM
AF von Bibra, H.
   Paulus, W. J.
   Sutton, M. St. John
   Leclerque, C.
   Schuster, T.
   Schumm-Draeger, P. -M.
TI Quantification of diastolic dysfunction via the age dependence of
   diastolic function - Impact of insulin resistance with and without type
   2 diabetes
SO INTERNATIONAL JOURNAL OF CARDIOLOGY
LA English
DT Article
DE Diastolic dysfunction; Tissue Doppler; Insulin resistance; Metabolic
   cardiomyopathy; Type 2 diabetes; Heart failure preserved ejection
   fraction
ID HEART-FAILURE; METABOLIC SYNDROME; EJECTION FRACTION; EUROPEAN-SOCIETY;
   CARDIAC-FUNCTION; ECHOCARDIOGRAPHY; DIAGNOSIS; STRESS
AB Background: The alarming prevalence of heart failure with preserved ejection fraction requires quantification of diastolic dysfunction (DDF). Myocardial diastolic velocity E' implies that age is the most important determinant. We tested the hypothesis that age allows for quantification of DDF and assessment of the structural and metabolic determinants in patients with and without type 2 diabetes (D).
   Methods: This prospective, cross-sectional study assessed cardiovascular, metabolic and ultrasound data in 409 consecutive patients (Diabetes Center, Bogenhausen-Munich) between 20 and 90 years without known cardiac disease and either with (n=204) or without D but with common prevalence of cardiovascular risk factors, including a subgroup of healthy individuals (H, n=94).
   Results: In H, E' related to age as: E'(norm)=-0.163 * years + 19.69 (R-2=0.77, p<0.0001). According to this 1% reduction by annual physiologic aging, DDF was quantitated as E'-E'(norm). Compared to nondiabetics, D patients were older, had greater BMI, lower E', more cardiovascular risk and greater DDF. In nondiabetics, grading of DDF by E-E'(norm) correlated with grading by filling pressure E/E'. Determinants of DDF by multivariate analysis included pulse wave velocity, diastolic blood pressure and the triglyceride/HDL ratio (a marker of insulin resistance) in nondiabetics and in D the same risk factors in reverse sequence and heart rate. Neither left atrial size nor left ventricular mass had significant impact.
   Conclusions: The physiological impact of age on myocardial function consists of a 1% annual reduction in E' and enables precise quantification of diastolic dysfunction thereby unmasking the importance of metabolic risk for DDF. (C) 2014 The Authors. Published by Elsevier Ireland Ltd.
C1 [von Bibra, H.; Leclerque, C.; Schumm-Draeger, P. -M.] Stadt Klinikum Munchen GmbH, Klinikum Bogenhausen, Clin Endocrinol Diabet & Vasc Med, Munich, Germany.
   [Paulus, W. J.] Vrije Univ Amsterdam, Vrije Univ, Med Ctr Amsterdam, Inst Cardiovasc Res, Amsterdam, Netherlands.
   [Sutton, M. St. John] Univ Penn, Dept Med, Cardiovasc Div, Philadelphia, PA 19104 USA.
   [Schuster, T.] Tech Univ Munich, Inst Stat & Epidemiol Med, D-80290 Munich, Germany.
C3 Munchen Klinik; Vrije Universiteit Amsterdam; University of
   Pennsylvania; Technical University of Munich
RP von Bibra, H (corresponding author), Klinikum Bogenhausen, Clin Endocrinol Diabet & Vasc Med, Munich, Germany.
EM vonbibra@gmx.de
RI Schuster, Tibor/LQJ-4546-2024
CR Bibra H., 2005, Diabetes Vasc Dis Res, V2, P483
   Borlaug BA, 2011, EUR HEART J, V32, P670, DOI 10.1093/eurheartj/ehq426
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NR 32
TC 30
Z9 30
U1 0
U2 7
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0167-5273
EI 1874-1754
J9 INT J CARDIOL
JI Int. J. Cardiol.
PD MAR 1
PY 2015
VL 182
BP 368
EP 374
DI 10.1016/j.ijcard.2014.12.005
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA CE6DU
UT WOS:000351927600104
PM 25594925
OA hybrid
DA 2025-06-11
ER

PT J
AU Litwin, M
   Michalkiewicz, J
   Trojanek, J
   Niemirska, A
   Wierzbicka, A
   Szalecki, M
AF Litwin, Mieczyslaw
   Michalkiewicz, Jacek
   Trojanek, Joanna
   Niemirska, Anna
   Wierzbicka, Aldona
   Szalecki, Mieczyslaw
TI Altered Genes Profile of Renin-Angiotensin System, Immune System, and
   Adipokines Receptors in Leukocytes of Children With Primary Hypertension
SO HYPERTENSION
LA English
DT Article
DE children; nonpharmacological treatment; primary hypertension;
   renin-angiotensin system genes
ID HIGH BLOOD-PRESSURE; METABOLIC SYNDROME; OXIDATIVE STRESS;
   BODY-COMPOSITION; T-CELLS; ADOLESCENTS; RECOMMENDATIONS; EXPRESSION;
   OBESITY; MASS
AB Renin-angiotensin system, metabolic abnormalities, and immune activity have a role in the pathogenesis of primary hypertension. We assessed the leukocyte mRNA expression of angiotensinogen, angiotensin converting enzyme, renin, angiotensin 2 type 1 receptor, CD14 molecule, adiponectin type 1 receptor, and leptin receptor in hypertensive children before and after nonpharmacological treatment. Leukocyte mRNA expression was measured by means of quantitative real-time reverse transcriptase-polymerase chain reaction in 23 hypertensive children before and after 6 months of nonpharmacological treatment based on dietary advice and physical activities. Twenty-three normotensive children matched for age, sex, and body mass index served as a control group. Before treatment patients had elevated expression of angiotensin converting enzyme and CD14 mRNA, decreased expression of angiotensinogen and angiotensin type 1 receptor mRNA, and unchanged expression of renin, adiponectin, and leptin receptors mRNA as compared with controls. Renin mRNA negatively correlated with 24-hour mean arterial pressure and carotid intima-media thickness. Six months of nonpharmacological treatment caused decrease of blood pressure and normalization of metabolic abnormalities. Renin, adiponectin, and leptin receptors mRNA expression decreased and were lower than in control group. Changes in blood pressure, left ventricular mass, carotid intima-media thickness, body mass index, and waist circumference did not correlate with changes in the expression of renin-angiotensin system genes, CD14, leptin, and adiponectin receptors mRNA. We conclude that leukocytes of hypertensive children displayed alterations in the expression of renin-angiotensin system genes as well as those of CD14. Nonpharmacological treatment resulted in downregulation of genes involved in renin-angiotensin activation and those engaged in leukocyte responses to adipokines. (Hypertension. 2013;61:431-436.)
C1 [Litwin, Mieczyslaw; Niemirska, Anna] Childrens Mem Hlth Inst, Dept Nephrol & Arterial Hypertens, PL-04730 Warsaw, Poland.
   [Michalkiewicz, Jacek; Trojanek, Joanna] Childrens Mem Hlth Inst, Dept Microbiol & Immunol, PL-04730 Warsaw, Poland.
   [Michalkiewicz, Jacek] Nicholas Copernicus Univ, Coll Med, Bydgoszcz, Poland.
   [Wierzbicka, Aldona] Childrens Mem Hlth Inst, Dept Biochem & Expt Med, PL-04730 Warsaw, Poland.
   [Szalecki, Mieczyslaw] Childrens Mem Hlth Inst, Dept Endocrinol, PL-04730 Warsaw, Poland.
   [Szalecki, Mieczyslaw] Jan Kochanowski Univ, Dept Hlth Sci, Kielce, Poland.
C3 Children's Memorial Health Institute; Children's Memorial Health
   Institute; Nicolaus Copernicus University; Ludwik Rydygier Collegium
   Medicum; Children's Memorial Health Institute; Children's Memorial
   Health Institute; Jan Kochanowski University
RP Litwin, M (corresponding author), Childrens Mem Hlth Inst, Dept Nephrol & Arterial Hypertens, Al Dzieci Polskich 20, PL-04730 Warsaw, Poland.
EM m.litwin@czd.pl
RI Michałkiewicz, Jacek/I-1135-2014; Szalecki, Mieczyslaw/AAI-3112-2021;
   Litwin, Mieczyslaw/L-4648-2017; Niemirska, Anna/W-2780-2018
OI Litwin, Mieczyslaw/0000-0002-5241-2483; Michalkiewicz,
   Jacek/0000-0001-7773-1766; Trojanek, Joanna/0000-0002-3200-735X;
   Wierzbicka-Rucinska, Aldona/0000-0002-9578-8894; Szalecki,
   Mieczyslaw/0000-0002-2950-761X; Niemirska, Anna/0000-0003-4546-5541
FU Ministry of Science and Higher Education [4552/B/P01/2009/37]
FX The study was supported by grant from Ministry of Science and Higher
   Education 4552/B/P01/2009/37.
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NR 32
TC 19
Z9 21
U1 0
U2 15
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0194-911X
EI 1524-4563
J9 HYPERTENSION
JI Hypertension
PD FEB
PY 2013
VL 61
IS 2
BP 431
EP 436
DI 10.1161/HYPERTENSIONAHA.111.00181
PG 6
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 073JU
UT WOS:000313740100044
PM 23266543
OA Bronze
DA 2025-06-11
ER

PT J
AU Wang, L
   Jiang, ZY
   Lei, XG
AF Wang, Li
   Jiang, Zongyong
   Lei, Xin Gen
TI Knockout of SOD1 alters murine hepatic glycolysis, gluconeogenesis, and
   lipogenesis
SO FREE RADICAL BIOLOGY AND MEDICINE
LA English
DT Article
DE Antioxidant enzyme; Reactive oxygen species; Glucose; Lipid; Mouse; Free
   radicals
ID ACTIVATED PROTEIN-KINASE; CELLULAR GLUTATHIONE-PEROXIDASE;
   ZINC-SUPEROXIDE-DISMUTASE; TYROSINE-PHOSPHATASE 1B; EXERT DIFFERENT
   IMPACTS; METABOLIC SYNDROME; OXIDATIVE STRESS; GENE-EXPRESSION;
   VENTRICULAR MYOCYTES; GLUCOSE-METABOLISM
AB We previously observed a stronger effect of knockout of Cu,Zn-superoxide dismutase (SOD1) than that of Se-dependent glutathione peroxidase 1 (GPX1) on murine body weight and glucose homeostasis. Two experiments were conducted to determine how hepatic lipid profiles and key metabolic regulators were correlated with this difference. SOD1(-/-) and GPX1(-/-) mice and their respective wild-type (WT) littermates (n=6 or 7/group, male) were fed a Se-adequate Torula yeast-sucrose diet and killed at 6 months of age to collect liver samples. In Experiment 1, fasted SOD1(-/-) mice displayed pyruvate intolerance and a 61% decrease (P<0.05) in liver glycogen compared with their WT littermates. The former had lower (P<0.05) activities of phosphoenolpyruvate carboxykinase, total protein phosphatase, and protein phosphatase 2A, but a higher (P<0.05) activity of glucokinase in the liver than the latter. In contrast, hepatic concentrations of total cholesterol, triglycerides, and nonesterified fatty acids were increased by 11 to 100% (P<0.05) in the SOD1(-/-) mice. Meanwhile, these mice had elevated (P<0.05) hepatic protein levels of sterol-regulatory element binding proteins 1 and 2, p53, total and phosphorylated AMP-activated protein kinase alpha 1 protein, protein tyrosine phosphatase 1B, and protein phosphatase 2B. In Experiment 2, GPX1(-/-) mice and their WT littermates were compared, but showed no difference in any of the measures. In conclusion, knockout of SOD1, but not GPX1, led to a decreased liver glycogen storage synchronized with pyruvate intolerance and elevated hepatic lipid profiles in adult mice. This striking comparison was possibly due to unique impacts of these two knockouts on intracellular tone of H2O2 and key regulators of liver gluconeogenesis, glycolysis, and lipogenesis. (C) 2012 Elsevier Inc. All rights reserved.
C1 [Wang, Li; Lei, Xin Gen] Cornell Univ, Dept Anim Sci, Ithaca, NY 14853 USA.
   [Wang, Li; Jiang, Zongyong] Guangdong Acad Agr Sci, Inst Anim Sci, Minist Agr, Key Lab Anim Nutr & Feed Sci S China, Guangzhou 510640, Guangdong, Peoples R China.
C3 Cornell University; Ministry of Agriculture & Rural Affairs; Guangdong
   Academy of Agricultural Sciences
RP Lei, XG (corresponding author), Cornell Univ, Dept Anim Sci, Ithaca, NY 14853 USA.
EM XL20@cornell.edu
FU National Institutes of Health [DK53108]
FX We are grateful for the technical assistance of Xiaodan Wang and Carol
   A. Roneker. This study was supported in part by National Institutes of
   Health Grant DK53108 to X.G.L.
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NR 65
TC 38
Z9 42
U1 0
U2 11
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0891-5849
J9 FREE RADICAL BIO MED
JI Free Radic. Biol. Med.
PD NOV 1
PY 2012
VL 53
IS 9
BP 1689
EP 1696
DI 10.1016/j.freeradbiomed.2012.08.570
PG 8
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 031RQ
UT WOS:000310660400007
PM 22974764
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Kassi, E
   Dalamaga, M
   Faviou, E
   Hroussalas, G
   Kazanis, K
   Nounopoulos, C
   Dionyssiou-Asteriou, A
AF Kassi, E.
   Dalamaga, M.
   Faviou, E.
   Hroussalas, G.
   Kazanis, K.
   Nounopoulos, Ch.
   Dionyssiou-Asteriou, A.
TI Circulating oxidized LDL levels, current smoking and obesity in
   postmenopausal women
SO ATHEROSCLEROSIS
LA English
DT Article
DE Oxidized LDL levels; Smoking; Obesity; Menopause
ID LOW-DENSITY-LIPOPROTEIN; CORONARY-ARTERY-DISEASE; OXIDATIVE STRESS;
   CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; ENDOTHELIAL-CELLS;
   BODY-COMPOSITION; HEART-DISEASE; RISK-FACTORS; SERUM-LEVELS
AB Objective: The aim of the present study was to estimate circulating oxidized low-density lipoprotein (oxLDL) levels in postmenopausal women and evaluate their association with obesity and smoking status.
   Design and methods: The study included 135 postmenopausal women aged 52-75 years. Forty of them were overweight (BMI 32.4 +/- 6.4) and non-smokers (Group A), 40 non-overweight (BMI 22.6 +/- 1.8) and smokers (Group B) and 55 non-overweight (BMI 23.5 +/- 1.4) and non-smokers (Group Q. oxLDL and antibodies against them (anti-oxLDL) were measured using ELISA. Serum total cholesterol, LDL, HDL and triglycerides were measured in an automated analyzer.
   Results: Total cholesterol, LDL, HDL and oxLDL serum levels were significantly elevated in Group A as compared to Group B or C, as well as oxLDL in Group B in comparison to Group C (p < 0.001). Triglycerides and anti-oxLDL were increased in Group A in comparison to Group C (p = 0.043 and 0.023). Total cholesterol, LDL, triglycerides and anti-oxLDL did not differ between Groups B and C, while HDL was decreased in Group B as compared to Group C (p < 0.001). A significant positive correlation was found between oxLDL and LDL in Group A (r = 0.53, p < 0.001) as well as in Group C (r = 0.955, p < 0.001) and a negative one between oxLDL and HDL in Group C (r = -0.933, p < 0.001). Regression analysis revealed that obesity was a stronger predictor of LDL oxidation than smoking.
   Conclusions: Postmenopausal obesity is involved in the process of LDL oxidation and appears to be a stronger predictor of LDL oxidation than smoking. Future studies are needed to confirm these associations. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
C1 [Dionyssiou-Asteriou, A.] Univ Athens, Sch Med, Dept Biol Chem, Athens 14564, Greece.
   Univ Athens, Sch Med, Dept Clin Biochem, Athens 14564, Greece.
C3 Athens Medical School; National & Kapodistrian University of Athens;
   National & Kapodistrian University of Athens; Athens Medical School
RP Dionyssiou-Asteriou, A (corresponding author), Univ Athens, Sch Med, Dept Biol Chem, 11 Korinthou Str, Athens 14564, Greece.
EM madalamaga@med.uoa.gr
RI Kassi, Eva/G-1278-2011; Dalamaga, Maria/A-4041-2013
OI Dalamaga, Maria/0000-0002-7008-388X
FU University of Athens
FX This work was partly supported by the Special Research Accounts of the
   University of Athens.
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NR 40
TC 41
Z9 42
U1 0
U2 4
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0021-9150
EI 1879-1484
J9 ATHEROSCLEROSIS
JI Atherosclerosis
PD JUL
PY 2009
VL 205
IS 1
BP 279
EP 283
DI 10.1016/j.atherosclerosis.2008.11.006
PG 5
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 472FJ
UT WOS:000268115000045
PM 19110250
DA 2025-06-11
ER

PT J
AU Tardif, JC
AF Tardif, Jean-Claude
TI The pivotal role of heart rate in clinical practice: from
   atherosclerosis to acute coronary syndrome
SO EUROPEAN HEART JOURNAL SUPPLEMENTS
LA English
DT Article
DE heart rate; atherosclerosis; risk factors; acute coronary syndrome
ID ALL-CAUSE MORTALITY; FOLLOW-UP; PSYCHOSOCIAL STRESS; INSULIN-RESISTANCE;
   PREDICTIVE VALUE; RATE REDUCTION; RISK-FACTOR; POPULATION; SEVERITY;
   DEATH
AB Heart rate is a predictor of major cardiovascular events in both the general population and patients with various cardiovascular diseases. The association between resting heart rate and mortality has been observed in patients with hypertension and with metabolic syndrome and in the elderly. The prognostic value of heart rate has also been shown in patients with stable coronary heart disease. We assessed the relationship between resting heart rate at baseline and cardiovascular mortality and morbidity, while adjusting for risk factors. A total of 24 913 patients with suspected or proven coronary artery disease from the Coronary Artery Surgery Study registry were studied for a median follow-up of close to 15 years. All-cause and cardiovascular mortality and cardiovascular re-hospitalizations were increased with increasing heart rate (P < 0.0001). When compared with the reference group, patients with resting heart rate >= 83 bpm at baseline had a significantly higher risk for total mortality [hazard ratio 1.32; confidence interval (CI) 1.19-1.47; P < 0.0001] and cardiovascular mortality (hazard ratio 1.31; CI 1.15-1.48; P < 0.0001) after adjustment for multiple clinical variables. When comparing patients with heart rates between 77-82 and >= 83 bpm with patients with a heart rate <= 62 bpm, the hazard ratios for time to first cardiovascular re-hospitalization were 1.11 and 1.14 (P < 0.001 for both). Resting heart rate has also been shown to be associated with the severity and rate of progression of coronary atherosclerosis and to be an independent predictor of plaque rupture in coronary arteries. Resting heart rate is a simple measurement with prognostic implications.
C1 Univ Montreal, Montreal Heart Inst, Dept Med, Montreal, PQ H1T 1C8, Canada.
C3 Universite de Montreal
RP Tardif, JC (corresponding author), Univ Montreal, Montreal Heart Inst, Dept Med, 5000 Belanger St, Montreal, PQ H1T 1C8, Canada.
EM jean-claude.tardif@icm-mhi.org
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NR 47
TC 3
Z9 3
U1 0
U2 1
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1520-765X
EI 1554-2815
J9 EUR HEART J SUPPL
JI Eur. Heart J. Suppl.
PD AUG
PY 2008
VL 10
IS F
BP F11
EP F16
DI 10.1093/eurheartj/sun021
PG 6
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 345KX
UT WOS:000258996800004
DA 2025-06-11
ER

PT J
AU Cianchetti, S
   Del Fiorentino, A
   Colognato, R
   Di Stefano, R
   Franzoni, F
   Pedrinelli, R
AF Cianchetti, Silvana
   Del Fiorentino, Alessandra
   Colognato, Renato
   Di Stefano, Rossella
   Franzoni, Ferdinando
   Pedrinelli, Roberto
TI Anti-inflammatory and anti-oxidant properties of telmisartan in cultured
   human umbilical vein endothelial cells
SO ATHEROSCLEROSIS
LA English
DT Article
DE telmisartan; angiotensin receptor blockers; adhesion molecules;
   TNF-alpha; angiotensin II; oxidative damage; endothelial cells
ID PROLIFERATOR-ACTIVATED RECEPTORS; INDUCED DNA-DAMAGE; NF-KAPPA-B;
   ANGIOTENSIN-II; ADHESION MOLECULE-1; SUPEROXIDE-PRODUCTION;
   SELECTIVE-INHIBITION; METABOLIC SYNDROME; GENE-EXPRESSION; HEART-FAILURE
AB Purpose: To study whether telmisartan, an angiotensin II (AII) receptor blocker (ARB), modulates endothelial inflammation and oxidative cell damage induced by AII-independent stimuli in cultured human umbilical vein endothelial cell (HUVEC)s.
   Methods: Endothelial inflammation, as reflected by increased VCAM-1 and ICAM-1 expression (ELISA), was induced by TNF-alpha, an inflammatory cytokine, and cell damage (COMET and MTT assay) by hydrogen peroxide, a reactive oxygen species. Losartan, another ARB, its active metabolites (EXP-3174, EXP-3179), dexamethasone, a synthetic steroid, and pyrrolidine dithiocarbamate (PDTC), an anti-oxidant, were the controls. The contribution of PPAR-gamma agonism was assessed through synthetic PPAR-gamma agonists and antagonists and the antagonism for All-type 1 receptor-mediated stimuli by evaluating the interference against cell death induced by AII (MTT assay), a pro-apoptotic peptide that induces oxidative stress. The in vitro scavenging properties for oxyradicals were quantified by the TOSC assay.
   Results: Telmisartan and PDTC reduced TNF-alpha-stimulated VCAM-1 in a concentration-dependent manner while losartan, EXP-3174, EXP-3179 and dexamethasone were ineffective. All compounds did not modify ICAM-1 expression. PPAR-gamma agonists or antagonists did not interfere with the effect of telmisartan. Both ARBs antagonized AII-induced cell death but only telmisartan reduced hydrogen peroxide-induced cell damage. Telmisartan scavenged selectively hydroxyl radicals without affecting peroxyl radicals and peroxynitrite.
   Conclusions: Telmisartan modulates pleiotropically TNF-alpha induced VCAM-1 expression and oxidative damage in vascular endothelium, possibly by acting as a hydroxyl radical scavenger. Those anti-inflammatory and antioxidant properties may contribute to the therapeutic effect, although the applicability of these data to the clinical situations has to be verified. (c) 2007 Elsevier Ireland Ltd. All rights reserved.
C1 [Cianchetti, Silvana; Del Fiorentino, Alessandra; Di Stefano, Rossella; Pedrinelli, Roberto] Univ Pisa, Dipartimento Cardio Toracico & Vascolare, I-56100 Pisa, Italy.
   [Colognato, Renato] Univ Pisa, Dipartimento Sci Uomo Ambiente, I-56100 Pisa, Italy.
   [Franzoni, Ferdinando] Univ Pisa, Dipartimento Med Interna, I-56100 Pisa, Italy.
C3 University of Pisa; University of Pisa; University of Pisa
RP Pedrinelli, R (corresponding author), Univ Pisa, Dipartimento Cardio Toracico & Vascolare, I-56100 Pisa, Italy.
EM r.pedrinelli@med.unipi.it
RI Di Stefano, Rossella/C-3880-2009; Franzoni, Ferdinando/AAC-2220-2019;
   Colognato, Renato/A-8520-2011
OI FRANZONI, FERDINANDO/0000-0003-2132-8788
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NR 43
TC 107
Z9 113
U1 1
U2 18
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0021-9150
EI 1879-1484
J9 ATHEROSCLEROSIS
JI Atherosclerosis
PD MAY
PY 2008
VL 198
IS 1
BP 22
EP 28
DI 10.1016/j.atherosclerosis.2007.09.013
PG 7
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 295RO
UT WOS:000255491800003
PM 17950296
DA 2025-06-11
ER

PT J
AU Vgontzas, AN
   Pejovic, S
   Zoumakis, E
   Lin, HM
   Bentley, CM
   Bixler, EO
   Sarrigiannidis, A
   Basta, M
   Chrousos, GP
AF Vgontzas, A. N.
   Pejovic, S.
   Zoumakis, E.
   Lin, H. -M.
   Bentley, C. M.
   Bixler, E. O.
   Sarrigiannidis, A.
   Basta, M.
   Chrousos, G. P.
TI Hypothalamic-pituitary-adrenal axis activity in obese men with and
   without sleep apnea: Effects of continuous positive airway pressure
   therapy
SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Article
ID CORTICOTROPIN-RELEASING HORMONE; BODY-FAT DISTRIBUTION; DAYTIME
   SLEEPINESS; METABOLIC SYNDROME; INSULIN-RESISTANCE; CORTISOL SECRETION;
   ABDOMINAL OBESITY; STRESS; ENDOCRINE; WOMEN
AB Context: Previous studies on the association between the hypothalamic-pituitary-adrenal axis activity and sleep apnea ( SA) and obesity are inconsistent and/or limited.
   Objective: In this study, we evaluated the activity of the hypothalamic-pituitary- adrenal axis in nonpsychologically distressed obese subjects with and without SA and examined the impact of continuous positive airway pressure ( CPAP) in SA patients.
   Design and Participants: In study I, four-night sleep laboratory recordings and serial 24-h plasma measures of cortisol were obtained in 45 obese men with and without apnea and nonobese controls. Sleep apneic patients were reassessed after 3 months of CPAP use. In study II, 38 obese men with and without sleep apnea and nonobese controls were challenged with ovine CRH administration after four nights in the sleep laboratory.
   Results: The sleep patterns were similar between obese and nonobese controls. Twenty-four-hour plasma cortisol levels were highest in nonobese controls, intermediate in obese apneic patients, and lowest in obese controls (8.8 +/- 0.4 vs. 8.1 +/- 0.3 vs. 7.5 +/- 0.3 mu g/dl, P < 0.05). CPAP tended to reduce cortisol levels in the apneic patients ( difference -0.7 +/-.4 mu g/dl, P = 0.1). CRH administration resulted in a higher ACTH response in both obese groups, compared with nonobese controls; the three groups were not different in cortisol response.
   Conclusions: Nonpsychologically distressed, normally sleeping, obese men had low cortisol secretion. The cortisol secretion was slightly activated by SA and returned to low by CPAP use. The low cortisol secretion in obesity through its inferred hyposecretion of hypothalamic CRH might predispose the obese to sleep apnea.
C1 Penn State Univ, Coll Med, Dept Psychiat, Sleep Res & Treatment Ctr, Hershey, PA 17033 USA.
   Univ Athens, Dept Pediat 1, GR-15784 Athens, Greece.
   Univ Athens, Unit Endocrinol Metab & Diabet, GR-15784 Athens, Greece.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE);
   Pennsylvania State University; Penn State Health; National &
   Kapodistrian University of Athens; National & Kapodistrian University of
   Athens
RP Vgontzas, AN (corresponding author), Penn State Univ, Coll Med, Dept Psychiat, Sleep Res & Treatment Ctr, H073,500 Univ Dr, Hershey, PA 17033 USA.
EM avgontzas@psu.edu
RI Basta, Maria/AAN-8744-2021
OI Basta, Maria/0000-0002-6629-8482
FU NCRR NIH HHS [RR010732, RR016499] Funding Source: Medline; NHLBI NIH HHS
   [R01 HL64415] Funding Source: Medline
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NR 43
TC 105
Z9 116
U1 0
U2 1
PU ENDOCRINE SOC
PI CHEVY CHASE
PA 8401 CONNECTICUT AVE, SUITE 900, CHEVY CHASE, MD 20815-5817 USA
SN 0021-972X
J9 J CLIN ENDOCR METAB
JI J. Clin. Endocrinol. Metab.
PD NOV
PY 2007
VL 92
IS 11
BP 4199
EP 4207
DI 10.1210/jc.2007-0774
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 228WR
UT WOS:000250763800020
PM 17785363
OA Bronze
DA 2025-06-11
ER

PT J
AU Wei, Y
   Whaley-Connell, AT
   Chen, K
   Habibi, J
   Uptergrove, GME
   Clark, SE
   Stump, CS
   Ferrario, CM
   Sowers, JR
AF Wei, Yongzhong
   Whaley-Connell, Adam T.
   Chen, Kemin
   Habibi, Javad
   Uptergrove, Grace M. -E.
   Clark, Suzanne E.
   Stump, Craig S.
   Ferrario, Carlos M.
   Sowers, James R.
TI NADPH oxidase contributes to vascular inflammation, insulin resistance,
   and remodeling in the transgenic (mRen2) rat
SO HYPERTENSION
LA English
DT Article
DE Ren2 rat; NADPH oxidase; ROS; vascular inflammation; insulin resistance;
   apoptosis
ID TUMOR-NECROSIS-FACTOR; SMOOTH-MUSCLE-CELLS; NF-KAPPA-B;
   RENIN-ANGIOTENSIN SYSTEM; OXIDATIVE STRESS; REACTIVE OXYGEN;
   NITRIC-OXIDE; ENDOTHELIAL DYSFUNCTION; METABOLIC SYNDROME; FACTOR-ALPHA
AB Reduced insulin sensitivity is characteristic of various pathological conditions such as type 2 diabetes mellitus and hypertension. Angiotensin II, acting through its angiotensin type 1 receptor, inhibits the actions of insulin in the vasculature which may lead to deleterious effects such as vascular inflammation, remodeling, endothelial dysfunction, and insulin resistance. In contrast, insulin normally exerts vasodilatory, antiinflammatory, and prosurvival actions. To explore the impact of angiotensin II on insulin signaling, NADPH oxidase - derived reactive oxygen species formation, vascular inflammation, apoptosis, and remodeling, we used transgenic TG(mRen2) 27 ( Ren2) rats, which harbor the mouse renin transgene and exhibits elevated tissue angiotensin II levels. Compared with Sprague-Dawley controls, Ren2 aortas exhibited greater NADPH oxidase activity, reactive oxygen species levels, C-reactive protein, tumor necrosis factor-alpha expression, apoptosis, and wall thickness, which were significantly attenuated by in vivo treatment with angiotensin type 1 receptor blockade (valsartan) or the superoxide dismutase/catalase mimetic (tempol). There was substantially diminished Akt and endothelial NO synthase activation in Ren2 aortas in response to in vivo insulin stimulation, and this was significantly improved by in vivo treatment with valsartan or tempol. In vivo treatment with valsartan, but not tempol, significantly reduced blood pressure in Ren2 rats. Further, there was reduced insulin induced Akt activation and increased tumor necrosis factor-alpha levels in vascular smooth muscle cells from Ren2 and Sprague-Dawley rats treated with angiotensin II, abnormalities that were abrogated by angiotensin type 1 receptor blockade with valsartan or antioxidant N-acetylcysteine. Collectively, these data suggest that increased angiotensin type 1 receptor/NADPH oxidase activation/reactive oxygen species contribute to vascular insulin resistance, endothelial dysfunction, apoptosis, and inflammation.
C1 Univ Missouri, Columbia, MO USA.
   Harry S Truman VA Med Ctr, Columbia, MO USA.
   Tucson Arizona VA Med Ctr, Tucson, AZ USA.
   Wake Forest Univ, Bowman Gray Sch Med, Winston Salem, NC 27109 USA.
C3 University of Missouri System; University of Missouri Columbia; US
   Department of Veterans Affairs; Veterans Health Administration (VHA);
   Harry S. Truman Memorial Veterans' Hospital; Wake Forest University;
   Wake Forest Baptist Medical Center
RP Sowers, JR (corresponding author), UHC, MU Diabet & Cardiovasc Ctr, Div Endocrinol, Diabet Ctr D109, 1 Hosp Dr, Columbia, MO 65212 USA.
EM Sowersj@health.missouri.edu
RI Ferrario, Carlos/ABD-2791-2020
OI Whaley-Connell, Adam/0000-0001-8955-5560; Ferrario, Carlos
   M/0000-0003-0792-6239
FU NHLBI NIH HHS [R01-HL073101-02, P01 HL-51952] Funding Source: Medline
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NR 46
TC 93
Z9 105
U1 0
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0194-911X
J9 HYPERTENSION
JI Hypertension
PD AUG
PY 2007
VL 50
IS 2
BP 384
EP 391
DI 10.1161/HYPERTENSIONAHA.107.089284
PG 8
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 192BT
UT WOS:000248176400021
PM 17533199
OA Bronze
DA 2025-06-11
ER

PT J
AU Kumari, M
   Seeman, T
   Marmot, M
AF Kumari, M
   Seeman, T
   Marmot, M
TI Biological predictors of change in functioning in the Whitehall II study
SO ANNALS OF EPIDEMIOLOGY
LA English
DT Article
DE health status; cardiovascular risk factors; insulin resistance
ID HEALTH SURVEY QUESTIONNAIRE; AGED OFFICE WORKERS; ALLOSTATIC LOAD;
   METABOLIC SYNDROME; FOLLOW-UP; SF-36; MACARTHUR; OBESITY; STRESS; RISK
AB PURPOSE: To examine whether risk factors for CHD are related to change in functioning independent of the presence or development of disease.
   METHODS: Longitudinal follow up of 4768 men and 2034 women civil servants from 20 London-based departments with complete data for the SF-36, biological variables, and BMI and health related behaviors. Data are used from two phases of the Whitehall II study, phase 3 (1991-1993) and phase 4 (1995) with an interval of 36 months. Weight, height, fasting insulin, 2-hour post load glucose, total and HDL-cholesterol, fibrinogen, von Willebrand factor, diastolic and systolic blood pressure, and waist hip ratio were measured at phase 3. Demographic and socio-economic information, health related behaviors, and the SF-36 were obtained at both phases by questionnaire.
   RESULTS: Waist hip ratio, fasting insulin, triglycerides, and HDL-cholesterol were associated with a decline in physical functioning in the total cohort and when those with poor health at baseline were removed from the analyses. Principal component analysis revealed that these variables clustered with total cholesterol and may represent insulin resistance. The biological variables had a cumulative effect on decline in physical functioning such that those with poor waist hip ratio, fasting insulin, triglycerides, and HDL-cholesterol was two times greater than those without. This relationship was independent of exercise, smoking, and alcohol intake which explained only 17% and 5.4% of the association in men and women, respectively.
   CONCLUSIONS: A number of biological variables, which may represent insulin resistance, are associated with decline in physical functioning in men and women independent of prevalent ill health or health related behaviors. (C) 2004 Elsevier Inc. All rights reserved.
C1 UCL, Dept Epidemiol & Publ Hlth, Int Ctr Hlth & Soc, London WC1E 6BT, England.
   Univ Calif Los Angeles, Dept Med, Div Geriatr, Los Angeles, CA USA.
C3 University of London; University College London; University of
   California System; University of California Los Angeles
RP Kumari, M (corresponding author), UCL, Dept Epidemiol & Publ Hlth, Int Ctr Hlth & Soc, 1-19 Torrington Pl, London WC1E 6BT, England.
EM M.Kumari@public-health.ucl.ac.uk
RI ; Marmot, Michael/Y-3920-2019
OI Kumari, Meena/0000-0001-9716-1035; Marmot, Michael/0000-0002-2431-6419
FU AHRQ HHS [R01-HS06516] Funding Source: Medline; Medical Research Council
   [G8802774, G19/35, G0100222] Funding Source: Medline; NHLBI NIH HHS
   [R01-HL36310] Funding Source: Medline; NIA NIH HHS [R01-AG13196] Funding
   Source: Medline
CR [Anonymous], MED CARE
   [Anonymous], 1994, SF 36 PHYS MENTAL SU
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NR 29
TC 16
Z9 17
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1047-2797
EI 1873-2585
J9 ANN EPIDEMIOL
JI Ann. Epidemiol.
PD APR
PY 2004
VL 14
IS 4
BP 250
EP 257
DI 10.1016/j.annepidem.2003.09.011
PG 8
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA 813BM
UT WOS:000220882600003
PM 15066604
DA 2025-06-11
ER

PT J
AU Zhu, XY
   Wei, JN
   Li, JL
   Zuo, SL
   Wang, JX
   Liu, N
AF Zhu, Xiuyuan
   Wei, Jiangnan
   Li, Jingling
   Zuo, Shunli
   Wang, Jiaxian
   Liu, Ning
TI The causal role of homocysteine in multiple diseases: a systematic
   review of Mendelian randomization studies
SO NUTRITION & METABOLISM
LA English
DT Review
DE Homocysteine; Mendelian randomization; Nervous system diseases;
   Cardiovascular diseases; Musculoskeletal system diseases
ID OXIDATIVE STRESS; HYPERHOMOCYSTEINEMIA; PATHOGENESIS; RISK
AB BackgroundHomocysteine (Hcy) has been implicated in the development of multiple diseases; however, its causal role remains unclear. Mendelian randomization (MR) studies provide a robust approach to assessing causality by minimizing confounding and reverse causation.ObjectiveThis study aimed to evaluate the causal role of Hcy in various diseases by synthesizing evidence from MR studies.MethodsWe performed a comprehensive literature search in PubMed, the Cochrane Library, Embase, and Web of Science for MR studies published up to May 30, 2024. Studies investigating the association between genetic predisposition to Hcy levels and specific diseases were included.ResultsFindings from 33 MR studies (covering 31 distinct primary outcomes) suggest that genetically elevated Hcy levels are associated with an increased risk of several health conditions, including: Five cardiovascular diseases: small vessel stroke, small artery occlusion stroke, stroke, subarachnoid hemorrhage, and ischemic stroke. Six musculoskeletal diseases: soft tissue disorders, osteoporosis with pathological fractures, hospital-diagnosed osteoarthritis (OA), overall OA, knee OA, and hip OA. One musculoskeletal biomarker: waist-to-hip ratio (WHR) adjusted for BMI. Two digestive system diseases: gastric cancer and non-alcoholic fatty liver disease. Three digestive biomarkers: alkaline phosphatase (ALP), alanine aminotransferase (ALT), and aspartate aminotransferase (AST). One urogenital system disease: chronic kidney disease. Two mental disorders: schizophrenia and bipolar disorder type I. One metabolic disorder: metabolic syndrome. Conversely, elevated Hcy levels are associated with a reduced risk of: One neurological disorder: multiple sclerosis. Two neurological biomarkers: gray matter volume and total brain volume. Five musculoskeletal biomarkers: heel bone mineral density (BMD), right/left grip strength, walking pace, and appendicular lean mass. One urogenital system biomarker: estimated glomerular filtration rate. Additionally, genetically reduced plasma Hcy levels correlated with higher forearm BMD.ConclusionThese findings provide significant evidence for the role of Hcy in disease causation and may contribute to the development of future preventive measures or therapeutic strategies.
C1 [Zhu, Xiuyuan; Wei, Jiangnan; Li, Jingling; Zuo, Shunli; Wang, Jiaxian] Zunyi Med Univ, Dept Nursing, Zhuhai Campus, Zhuhai 519090, Guangdong, Peoples R China.
   [Liu, Ning] Zunyi Med Univ, Dept Fundamentals, Dept Basic Teaching & Res Gen Med, Zhuhai Campus, Zhuhai 519090, Guangdong, Peoples R China.
C3 Zunyi Medical University; Zunyi Medical University
RP Liu, N (corresponding author), Zunyi Med Univ, Dept Fundamentals, Dept Basic Teaching & Res Gen Med, Zhuhai Campus, Zhuhai 519090, Guangdong, Peoples R China.
EM ln761066906@163.com
FU National Natural Science Foundation of China [82260281]; Science and
   Technology Fund Project of Guizhou Provincial Health Commission
   [gzwkj2023-588]; Scientific study on the Construction of shared Medical
   Model and Optimization Mechanism for patients with Stroke Depression in
   low Resource area; Guizhou Science and Technology Plan Project, Guizhou
   Science and Technology Cooperation (Qiankehe) Foundation [ZK [2024] key
   Project 069]; First Cohort of Zunyi Medical University's Future Leading
   Teachers Grant Program [12345]
FX This study was supported by the National Natural Science Foundation of
   China (Project No. 82260281) and the Science and Technology Fund Project
   of Guizhou Provincial Health Commission (gzwkj2023-588);Scientific study
   on the Construction of shared Medical Model and Optimization Mechanism
   for patients with Stroke Depression in low Resource area. Guizhou
   Science and Technology Plan Project, Guizhou Science and Technology
   Cooperation (Qiankehe) Foundation(NO: ZK [2024] key Project 069). The
   First Cohort of Zunyi Medical University's Future Leading Teachers Grant
   Program (No. 12345).
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NR 57
TC 0
Z9 0
U1 0
U2 0
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1743-7075
J9 NUTR METAB
JI Nutr. Metab.
PD MAY 20
PY 2025
VL 22
IS 1
AR 45
DI 10.1186/s12986-025-00933-0
PG 32
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 2UI3B
UT WOS:001491504100001
PM 40394620
DA 2025-06-11
ER

PT J
AU Ahmed, R
   Safa, MR
   Zahid, ZI
   Chowdhury, MMI
   Hasan, ABMK
   Mostaid, MS
   Reza, HM
AF Ahmed, Rezwana
   Safa, Mushfikur Rahman
   Zahid, Zahidul Islam
   Chowdhury, Md. Mazharul Islam
   Hasan, A. B. M. Kamrul
   Mostaid, Md. Shaki
   Reza, Hasan Mahmud
TI Association of SIRT1 rs3758391 Polymorphism With T2DM in
   Bangladeshi Population: Evidence From a Case-Control Study and
   Meta-Analysis
SO HEALTH SCIENCE REPORTS
LA English
DT Article
DE Bangladesh; risk; rs3578391; SIRT1; type 2 diabetes mellitus
ID METABOLIC SYNDROME; CELL-SURVIVAL; DISEASE; TRANSCRIPTION; EXPRESSION;
   PROTECTS; SIRTUINS; TARGET; DIET
AB Background and AimType 2 diabetes mellitus (T2DM) remains one of the major causes of morbidity and mortality worldwide, including Bangladesh. SIRT1, an NAD-dependent deacetylase, is involved in energy homeostasis and protects beta-cells of the pancreas from oxidative stress. Single nucleotide polymorphisms (SNPs) in the SIRT1 gene have been found to be associated with T2DM in several populations, however, with conflicting results. The aim of this present case-control study, along with the meta-analysis, was to elucidate the association of rs3758391 polymorphism with the susceptibility to T2DM in Bangladeshi population.Methods72 T2DM patients and 90 healthy controls were enrolled in our study and polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was employed for genotyping the SNP. Odds ratio (OR) with 95% confidence interval (95% CI) was used to represent the association of SIRT1 polymorphism with T2DM. For the meta-analysis six studies were included and pooled odds ratio with 95% CI were calculated for six genetic models using the random effects model. Heterogeneity and publication bias was also calculated for each study.ResultsA significant association was found between rs3758391 polymorphism and increased risk of T2DM under codominant TT versus CC (OR = 3.88, 95% CI = 1.34-11.25, p = 0.012), recessive TT versus CC + CT (OR = 2.83, 95% CI = 1.12-7.09, p = 0.027) and allelic T versus C (OR = 1.67, 95% CI = 1.07-2.60, p = 0.024) genetic models. However, no significant association between rs3758391 and other biochemical and anthropometric parameters were found. Our meta-analysis showed no statistically significant association of this polymorphism.ConclusionWe conclude that, polymorphism at rs3758391 of SIRT1 gene conferred an increased risk of T2DM in Bangladeshi population.
C1 [Ahmed, Rezwana; Safa, Mushfikur Rahman; Zahid, Zahidul Islam; Chowdhury, Md. Mazharul Islam; Mostaid, Md. Shaki; Reza, Hasan Mahmud] North South Univ, Dept Pharmaceut Sci, Dhaka, Bangladesh.
   [Chowdhury, Md. Mazharul Islam] Appalachian Coll Pharm, Oakwood, VA USA.
   [Hasan, A. B. M. Kamrul] Mymensingh Med Coll, Dept Endocrinol, Mymensingh, Bangladesh.
C3 North South University (NSU); Mymensingh Medical College
RP Ahmed, R; Reza, HM (corresponding author), North South Univ, Dept Pharmaceut Sci, Dhaka, Bangladesh.
EM rezwana.ahmed01@northsouth.edu; hasan.reza@northsouth.edu
RI Reza, Hasan Mahmud/AFL-0151-2022; Chowdhury, Md
   Mahmud-Ul-Tarik/HNJ-5528-2023; Mostaid, Md Shaki/JDC-1405-2023; KAMRUL
   HASAN, ABUL BASHAR MOHAMMAD/AAC-8348-2020
OI KAMRUL HASAN, ABUL BASHAR MOHAMMAD/0000-0002-5681-6522; Mostaid, Md
   Shaki/0000-0002-9229-651X; Zahid, Md. Zahidul Islam/0009-0000-9683-1850
FU The research was supported by research grant (CTRGC-20/SHLS/31) from
   North South University. [CTRGC-20/SHLS/31]; North South University
FX The authors are grateful to Dr. Farhana and Dr. Sadia Ahmed, for their
   assistance in data collection. This work was financially supported by a
   research grant (CTRGC-20/SHLS/31) from North South University.
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NR 58
TC 0
Z9 0
U1 2
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
EI 2398-8835
J9 HEALTH SCI REP-US
JI Health Sci. Rep.
PD FEB
PY 2025
VL 8
IS 2
AR e70495
DI 10.1002/hsr2.70495
PG 12
WC Public, Environmental & Occupational Health; Medicine, General &
   Internal
WE Emerging Sources Citation Index (ESCI)
SC Public, Environmental & Occupational Health; General & Internal Medicine
GA X4P4C
UT WOS:001425185900001
PM 39980831
OA gold
DA 2025-06-11
ER

PT J
AU Kreouzi, M
   Theodorakis, N
   Nikolaou, M
   Feretzakis, G
   Anastasiou, A
   Kalodanis, K
   Sakagianni, A
AF Kreouzi, Magdalini
   Theodorakis, Nikolaos
   Nikolaou, Maria
   Feretzakis, Georgios
   Anastasiou, Athanasios
   Kalodanis, Konstantinos
   Sakagianni, Aikaterini
TI Skin Microbiota: Mediator of Interactions Between Metabolic Disorders
   and Cutaneous Health and Disease
SO MICROORGANISMS
LA English
DT Review
DE metabolic disorders; skin microbiota; biomarkers; atopic dermatitis;
   psoriasis; acne; precision dermatology
ID ASSOCIATION; ROSACEA
AB Metabolic disorders, including type 2 diabetes mellitus (T2DM), obesity, and metabolic syndrome, are systemic conditions that profoundly impact the skin microbiota, a dynamic community of bacteria, fungi, viruses, and mites essential for cutaneous health. Dysbiosis caused by metabolic dysfunction contributes to skin barrier disruption, immune dysregulation, and increased susceptibility to inflammatory skin diseases, including psoriasis, atopic dermatitis, and acne. For instance, hyperglycemia in T2DM leads to the formation of advanced glycation end products (AGEs), which bind to the receptor for AGEs (RAGE) on keratinocytes and immune cells, promoting oxidative stress and inflammation while facilitating Staphylococcus aureus colonization in atopic dermatitis. Similarly, obesity-induced dysregulation of sebaceous lipid composition increases saturated fatty acids, favoring pathogenic strains of Cutibacterium acnes, which produce inflammatory metabolites that exacerbate acne. Advances in metabolomics and microbiome sequencing have unveiled critical biomarkers, such as short-chain fatty acids and microbial signatures, predictive of therapeutic outcomes. For example, elevated butyrate levels in psoriasis have been associated with reduced Th17-mediated inflammation, while the presence of specific Lactobacillus strains has shown potential to modulate immune tolerance in atopic dermatitis. Furthermore, machine learning models are increasingly used to integrate multi-omics data, enabling personalized interventions. Emerging therapies, such as probiotics and postbiotics, aim to restore microbial diversity, while phage therapy selectively targets pathogenic bacteria like Staphylococcus aureus without disrupting beneficial flora. Clinical trials have demonstrated significant reductions in inflammatory lesions and improved quality-of-life metrics in patients receiving these microbiota-targeted treatments. This review synthesizes current evidence on the bidirectional interplay between metabolic disorders and skin microbiota, highlighting therapeutic implications and future directions. By addressing systemic metabolic dysfunction and microbiota-mediated pathways, precision strategies are paving the way for improved patient outcomes in dermatologic care.
C1 [Kreouzi, Magdalini] Amalia Fleming Gen Hosp, Dept Internal Med, 14 25th Martiou Str, Athens 15127, Greece.
   [Theodorakis, Nikolaos] Clin Metab & Athlet Performance, NT Cardiometab, 47 Tirteou Str, Palaio Faliro 17564, Greece.
   [Theodorakis, Nikolaos; Nikolaou, Maria] Amalia Fleming Gen Hosp, Dept Cardiol & Prevent Cardiol Outpatient Clin, 14 25th Martiou Str, Melissia 15127, Greece.
   [Theodorakis, Nikolaos] Natl & Kapodistrian Univ Athens, Sch Med, 75 Mikras Asias, Athens 11527, Greece.
   [Theodorakis, Nikolaos; Feretzakis, Georgios] Hellen Open Univ, Sch Sci & Technol, 18 Aristotelous Str, Patras 26335, Greece.
   [Anastasiou, Athanasios] Natl Tech Univ Athens, Biomed Engn Lab, Athens 15780, Greece.
   [Kalodanis, Konstantinos] Harokopio Univ Athens, Dept Informat & Telemat, Kallithea 17676, Greece.
   [Sakagianni, Aikaterini] Sismanogleio Gen Hosp, Intens Care Unit, 37 Sismanogleiou Str, Maroussi 15126, Greece.
C3 National & Kapodistrian University of Athens; Athens Medical School;
   Hellenic Open University; National Technical University of Athens;
   Harokopio University Athens
RP Sakagianni, A (corresponding author), Sismanogleio Gen Hosp, Intens Care Unit, 37 Sismanogleiou Str, Maroussi 15126, Greece.
EM kreouzi.m@live.unic.ac.cy; n.theodorakis@flemig-hospital.gr;
   m.nikolaou@flemig-hospital.gr; aanastasiou@biomed.ntua.gr;
   kkalodanis@hua.gr; sakagianni@sismanoglio.gr
RI Theodorakis, Nikolaos/KHT-3463-2024; FERETZAKIS, GEORGIOS/AAQ-5130-2020;
   Kreouzi, Magdalini/IQW-6202-2023; SAKAGIANNI, KATERINA/KHE-0770-2024
OI NIKOLAOU, MARIA/0000-0003-2481-5936; FERETZAKIS,
   GEORGIOS/0000-0002-3597-1187; Kalodanis,
   Konstantinos/0000-0003-2456-9261; SAKAGIANNI,
   KATERINA/0000-0002-3199-9158; Anastasiou,
   Athanasios/0000-0001-6679-3590; Theodorakis,
   Nikolaos/0000-0003-0420-7327
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NR 91
TC 1
Z9 1
U1 10
U2 10
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-2607
J9 MICROORGANISMS
JI Microorganisms
PD JAN
PY 2025
VL 13
IS 1
AR 161
DI 10.3390/microorganisms13010161
PG 32
WC Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Microbiology
GA T4C5F
UT WOS:001404507200001
PM 39858932
OA gold
DA 2025-06-11
ER

PT J
AU Gheitasi, I
   Savari, F
   Akbari, G
   Mohammadi, J
   Fallahzadeh, AR
   Sadeghi, H
AF Gheitasi, Izadpanah
   Savari, Feryal
   Akbari, Ghaidafeh
   Mohammadi, Jamshid
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   Sadeghi, Hossein
TI Molecular Mechanisms of Hawthorn Extracts in Multiple Organs Disorders
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SO INTERNATIONAL JOURNAL OF ENDOCRINOLOGY
LA English
DT Review
ID INDUCED OXIDATIVE STRESS; CRATAEGUS-PINNATIFIDA; INSULIN-RESISTANCE;
   IN-VITRO; METABOLIC SYNDROME; ALPHA-GLUCOSIDASE; P38 MAPK; RATS;
   PATHOGENESIS; EXPRESSION
AB Diabetes mellitus (DM) is one of the most important metabolic disorders associated with chronic hyperglycemia and occurs when the body cannot manage insulin secretion, insulin action, or both. Autoimmune destruction of pancreatic beta cells and insulin resistance are the major pathophysiological factors of types 1 and 2 of DM, respectively. Prolonged hyperglycemia leads to multiple organs dysfunctions, including nephropathy, neuropathy, cardiomyopathy, gastropathy, and micro- and macrovascular disorders. The basis of the metabolic abnormalities in carbohydrate, fat, and protein in diabetes is insufficient action of insulin on various target tissues. Medicinal plants are rich sources of bioactive chemical compounds with therapeutic effects. The beneficial effects of leaves, fruits, and flowers extracts of Crataegus oxyacantha, commonly called hawthorn, belonging to the Rosaceae family, are widely used as hawthorn-derived medicines. Data in this review have been collected from the scientific articles published in databases such as Science Direct, Scopus, PubMed, Web of Science, and Scientific Information Database from 2000 to 2021. Based on this review, hawthorn extracts appear both therapeutic and protective effects against diabetic-related complications in various organs through molecular mechanisms, such as decreasing triglyceride, cholesterol, very low density lipoprotein and increasing the antioxidant activity of superoxide dismutase, catalase, glutathione peroxidase, total antioxidant capacity, decreasing malondialdehyde level, and attenuating tumor necrosis factor alpha, interleukin 6 and sirtuin 1/AMP-activated protein kinase (AMPK)/nuclear factor kappa B (NF-kappa B) pathway and increasing the phosphorylation of glucose transporter 4, insulin receptor substrate 1, AKT and phosphoinositide 3-kinases, and attenuating blood sugar and regulation of insulin secretion, insulin resistance, and improvement of histopathological changes in pancreatic beta cells. Collectively, hawthorn can be considered as one new target for the research and development of innovative drugs for the prevention or treatment of DM and related problems.
C1 [Gheitasi, Izadpanah; Akbari, Ghaidafeh; Mohammadi, Jamshid; Sadeghi, Hossein] Yasuj Univ Med Sci, Med Plants Res Ctr, Yasuj, Iran.
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C3 Yasouj University; Yasouj University
RP Akbari, G; Mohammadi, J (corresponding author), Yasuj Univ Med Sci, Med Plants Res Ctr, Yasuj, Iran.
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NR 132
TC 6
Z9 7
U1 5
U2 28
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1687-8337
EI 1687-8345
J9 INT J ENDOCRINOL
JI Int. J. Endocrinol.
PD JUN 7
PY 2022
VL 2022
AR 2002768
DI 10.1155/2022/2002768
PG 14
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 2G4TO
UT WOS:000813589500001
PM 35711333
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Nedeva, I
   Gateva, A
   Assyov, Y
   Karamfilova, V
   Velikova, T
   Kamenov, Z
AF Nedeva, Iveta
   Gateva, Antoaneta
   Assyov, Yavor
   Karamfilova, Vera
   Velikova, Tsvetelina
   Kamenov, Zdravko
TI Neopterin in the Evolution from Obesity to Prediabetes and Newly
   Diagnosed Type 2 Diabetes
SO METABOLIC SYNDROME AND RELATED DISORDERS
LA English
DT Article
DE carbohydrate disturbances; metabolic syndrome; diabetes complications
ID URINARY NEOPTERIN; SERUM NEOPTERIN; INFLAMMATION; MARKER
AB Background: Neopterin, marker of cellular immunity and oxidative stress, is mainly produced by activated macrophages. It could play a crucial role in the development of insulin resistance (IR) and type 2 diabetes (T2D). The aim of this study was to investigate the circulating levels of neopterin in different stages of glucose dysregulation from obesity through prediabetes to newly diagnosed diabetes.
   Methods: Neopterin levels were determined using a commercially available human enzyme-linked immunosorbent assay kit. The homeostasis model assessment of IR was used as an index to assess IR.
   Results: The sample consisted of 163 subjects with mean age 52.5 +/- 11.3 years, divided in three age- and body mass index (BMI)-matched groups-obesity, prediabetes, and diabetes. The control group consisted of 42 healthy individuals. Neopterin levels were significantly higher in patients with obesity and/or prediabetes and newly diagnosed diabetes than those in the control group, respectively (4.14 +/- 2.51; 4.04 +/- 2.80 and 2.17 +/- 1.93 vs. 0.87 +/- 0.84; P < 0.05). Correlation analysis showed that the level of neopterin positively correlated with BMI, waist, waist-to-stature ratio, waist-to-hip ratio, fasting glucose, and triglycerides. Receiver operating characteristic analysis established neopterin suitable for distinguishing subjects with obesity [area under the curve (AUC) = 0.83; P < 0.001] and carbohydrate disturbances (AUC = 0.59; P < 0.05) from those without these conditions. Neopterin >= 0.47 ng/mL have an odds ratio (OR) of 2.71 for development of dysglycemia, whereas threshold value of neopterin >= 0.56 ng/mL shows an OR of 5.94 for development of obesity.
   Conclusion: The levels of neopterin were increased in patients with obesity and carbohydrate disturbances. Further studies will elucidate the role of the biomarker in development of T2D and its complications.
C1 [Nedeva, Iveta; Gateva, Antoaneta; Assyov, Yavor; Karamfilova, Vera; Kamenov, Zdravko] Med Univ Sofia, Clin Endocrinol, Dept Internal Med, Univ Hosp Alexandrovska, 1 Georgi Sofiiski St, Sofia 1431, Bulgaria.
   [Velikova, Tsvetelina] Med Univ Sofia, Clin Immunol Lab, Dept Clin Lab & Clin Immunol, Univ Hosp Lozenetz, Sofia, Bulgaria.
C3 Medical University Sofia; Medical University Sofia; University of Sofia
RP Nedeva, I (corresponding author), Med Univ Sofia, Clin Endocrinol, Dept Internal Med, Univ Hosp Alexandrovska, 1 Georgi Sofiiski St, Sofia 1431, Bulgaria.
EM iveta_nedeva@yahoo.com
RI Karamfilova, Vera/AFI-4187-2022; Assyov, Yavor/LWI-7733-2024; Gateva,
   Antoaneta/AGT-4861-2022; Velikova, Tsvetelina/H-6932-2019
OI Velikova, Tsvetelina/0000-0002-0593-1272
FU Medical University-Sofia, Bulgaria [8269/21.11.2018, D-124/2019]
FX The study was performed with the financial support of Medical
   University-Sofia, Bulgaria, project no. 8269/21.11.2018, contract
   D-124/2019.
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NR 39
TC 0
Z9 0
U1 0
U2 9
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-4196
EI 1557-8518
J9 METAB SYNDR RELAT D
JI Metab. Syndr. Relat. Disord.
PD MAY 1
PY 2021
VL 19
IS 4
BP 249
EP 255
DI 10.1089/met.2020.0144
EA FEB 2021
PG 7
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA RZ6DA
UT WOS:000621633500001
PM 33599536
DA 2025-06-11
ER

PT J
AU Arabska, J
   Margulska, A
   Strzelecki, D
   Wysokinski, A
AF Arabska, Jasmina
   Margulska, Aleksandra
   Strzelecki, Dominik
   Wysokinski, Adam
TI Does metabolic status affect serum levels of BDNF and MMP-9 in patients
   with schizophrenia?
SO NORDIC JOURNAL OF PSYCHIATRY
LA English
DT Article
DE Schizophrenia; BDNF; MMP-9; body composition; metabolic syndrome
ID NEUROTROPHIC FACTOR BDNF; NEGATIVE SYMPTOMS; OXIDATIVE STRESS;
   PLASMA-LEVELS; BRAIN; MATRIX-METALLOPROTEINASE-9; PLASTICITY; DISORDER;
   PEOPLE
AB The purpose of the article: Brain-derived neurotrophic factor (BDNF) and matrix metalloproteinase-9 (MMP-9) are involved in the processes of neurogenesis, synaptic plasticity, learning and memory. Growing number of studies shows a relationship between BDNF or MMP-9 and schizophrenia. Also, BDNF and MMP-9 levels may be affected by metabolic parameters, such as obesity or dyslipidemia. Our hypothesis is that alterations of BDNF or MMP-9 levels in schizophrenia might be secondary to metabolic abnormalities, often found among schizophrenia patients. Materials and methods: We have compared BDNF and MMP-9 between patients with schizophrenia (n = 64, age 49 +/- 8.2 y) and healthy controls (n = 32, age 51 +/- 8.9 y) in the context of cardio-metabolic parameters. Serum levels of BDNF and MMP-9 were measured using ELISA test, body composition parameters were determined using bioelectric impedance analysis. Results and conclusions: Our results showed significantly lowered serum BDNF concentration in the schizophrenia group (schizophrenia: 23.8 +/- 7.83 ng/mL, control: 27.69 +/- 8.11 ng/mL, p = 0.03). Serum MMP-9 concentration in schizophrenia group did not differ compared with the control group (schizophrenia: 456.8 +/- 278.4 ng/mL, control: 341.5 +/- 162.4 ng/mL, p = 0.07). After adjusting for age, all anthropometric parameters, body composition and laboratory tests BDNF were still significantly lower in the schizophrenia group. However, MMP-9 became significantly elevated in the schizophrenia group after adjusting for several anthropometric and body composition covariates. Our results confirmed reduced serum BDNF concentration in patients with schizophrenia. Also, this reduction seems to be independent of metabolic abnormalities. On the other hand, our hypothesis that MMP-9 level in schizophrenia is altered due to metabolic abnormalities might be true.
C1 [Arabska, Jasmina; Margulska, Aleksandra; Wysokinski, Adam] Med Univ Lodz, Dept Old Age Psychiat & Psychot Disorders, Czechoslowacka 8-10, PL-92216 Lodz, Poland.
   [Strzelecki, Dominik] Med Univ Lodz, Dept Affect & Psychot Disorders, Lodz, Poland.
C3 Medical University Lodz; Medical University Lodz
RP Wysokinski, A (corresponding author), Med Univ Lodz, Dept Old Age Psychiat & Psychot Disorders, Czechoslowacka 8-10, PL-92216 Lodz, Poland.
EM adam.wysokinski@umed.lodz.pl
RI Strzelecki, Dominik/S-9340-2016; Wysokinski, Adam/S-9294-2016;
   Wysokinski, Adam/G-8174-2014
OI Strzelecki, Dominik/0000-0002-8559-1078; Margulska,
   Aleksandra/0000-0003-1229-0925; Wysokinski, Adam/0000-0002-6159-6579
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NR 40
TC 12
Z9 12
U1 0
U2 3
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0803-9488
EI 1502-4725
J9 NORD J PSYCHIAT
JI Nord. J. Psychiatr.
PD NOV 17
PY 2019
VL 73
IS 8
BP 515
EP 521
DI 10.1080/08039488.2019.1658126
EA AUG 2019
PG 7
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA JB9EP
UT WOS:000484157800001
PM 31464540
DA 2025-06-11
ER

PT J
AU Liu, KL
   Kuo, WC
   Lin, CY
   Lii, CK
   Liu, YL
   Cheng, YH
   Tsai, CW
AF Liu, Kai-Li
   Kuo, Wen-Chen
   Lin, Chia-Yuan
   Lii, Chong-Kuei
   Liu, Yen-Lin
   Cheng, Yun-Hsin
   Tsai, Chia-Wen
TI Prevention of 4-hydroxynonenal- induced lipolytic activation by carnosic
   acid is related to the induction of glutathione S-transferase in 3T3-L1
   adipocytes
SO FREE RADICAL BIOLOGY AND MEDICINE
LA English
DT Article
DE Carnosic acid; 4-hydroxynonenal; Lipolysis; beta-oxidation; Glutathione
   S-transferase
ID INSULIN-RESISTANCE; OXIDATIVE STRESS; METABOLIC SYNDROME; MITOCHONDRIAL
   DYSFUNCTION; PROTEIN CARBONYLATION; SKELETAL-MUSCLE; OBESITY; PRODUCT;
   MICE; TARGET
AB Induction of 4-hydroxynonenal (4-HNE), a major lipid peroxidation aldehyde, is observed in patients with obesity and type 2 diabetes mellitus. The lipolytic response by 4-HNE has been linked to insulin resistance. In this study, we investigated the effects of carnosic acid (CA) on 4-HNE-induced lipolysis and the inhibition of beta-oxidation in 3T3-L1 adipocytes. The results indicated that cells pretreated with CA reduced 4-HNE-mediated free fatty acid (FFA) release. Furthermore, CA reversed the inhibition of phosphorylation of Tyr(632) of insulin receptor substrate-1 (IRS-1) and Akt and the phosphorylation of Ser(307) of IRS-1. CA inhibited 4-HNE-induced phosphorylation of protein kinase A (PKA) and hormone-sensitive lipase (HSL), and reversed the suppression by 4HNE of phosphorylation of AMP-activated protein kinase (AMPK) and acetyl-CoA carboxylase (p < 0.05). Pretreatment of cells with forskolin (a cAMP agonist) and compound C (an AMPK inhibitor) reversed these effects, respectively (p < 0.05). In human subcutaneous adipocytes, CA also attenuated 4-HNE-induced FFA release and the phosphorylation of PKA and HSL (p < 0.05). Moreover, CA increased the protein expression of glutathione S-transferase (GST) A and M. Pretreatment with ethacrynic acid, a GST inhibitor, prevented the 4-HNE-conjugated proteins suppression, the PKA and HSL phosphorylation reduction, and the FFA release inhibition by CA (p < 0.05). Conclusion: The attenuation by CA of the lipolytic response by 4-HNE is likely related to the induction of GST, which in turn reduced 4-HNE-conjugated proteins and decreased the activation of the PKA/HSL pathway. The observed effects may explain how CA improves 4-HNE-induced insulin resistance.
C1 [Liu, Kai-Li] Chung Shan Med Univ, Dept Nutr, Taichung, Taiwan.
   [Liu, Kai-Li] Chung Shan Med Univ Hosp, Dept Dietitian, Taichung, Taiwan.
   [Kuo, Wen-Chen; Lin, Chia-Yuan; Lii, Chong-Kuei; Liu, Yen-Lin; Cheng, Yun-Hsin; Tsai, Chia-Wen] China Med Univ, Dept Nutr, 91 Hsueh Shih Rd, Taichung 404, Taiwan.
C3 Chung Shan Medical University; Chung Shan Medical University; Chung Shan
   Medical University Hospital; China Medical University Taiwan
RP Tsai, CW (corresponding author), China Med Univ, Dept Nutr, 91 Hsueh Shih Rd, Taichung 404, Taiwan.
EM cwtsai@mail.cmu.edu.tw
RI Li, Jenny/GSD-3780-2022; chen, ying/HHS-8254-2022
FU Ministry of Science and Technology [NSC-101-2320-B-039-052-MY2]
FX This study was supported by the Ministry of Science and Technology
   (NSC-101-2320-B-039-052-MY2).
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NR 40
TC 11
Z9 13
U1 0
U2 13
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0891-5849
EI 1873-4596
J9 FREE RADICAL BIO MED
JI Free Radic. Biol. Med.
PD JUN
PY 2018
VL 121
BP 1
EP 8
DI 10.1016/j.freeradbiomed.2018.04.567
PG 8
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA GH2CC
UT WOS:000433208200001
PM 29698741
DA 2025-06-11
ER

PT J
AU Lemiesz, M
   Tenderenda-Banasiuk, E
   Sosnowska, D
   Rybi-Szumniska, A
   Storonowicz, J
   Lemiesz, T
   Wasilewska, A
AF Lemiesz, Marta
   Tenderenda-Banasiuk, Edyta
   Sosnowska, Dorota
   Rybi-Szumniska, Agnieszka
   Storonowicz, Justyna
   Lemiesz, Tomasz
   Wasilewska, Anna
TI The Possible Impact of Hyperuricemia on Serum Soluble Receptor for
   Advanced Glycation end Products (sRAGE) Levels in Teenagers: A Case
   Control Study
SO CURRENT PHARMACEUTICAL DESIGN
LA English
DT Article
DE Adolescents; AGEs; Children; Hypertension; Hyperuricemia; sRAGE
ID URIC-ACID; METABOLIC SYNDROME; RAGE; PLASMA; ENDPRODUCTS; DISEASE;
   STRESS; AGES; PATHOGENESIS; CHILDREN
AB Background: Dietary advanced glycation end products (AGEs) and their interactions with the soluble receptors for AGEs (RAGE) play a crucial role in the pathogenesis of cardiovascular diseases.
   Objective: This study was set out to assess, whether there was any association between serum sRAGE level and serum uric acid level in children with hyperuricemia.
   Methods: This case-control study involved 53 patients (12 girls, 41 boys) with hyperuricemia (defined as serum uric acid >4.8 and >5.5 mg/dl in girls and boys, respectively) aged (median [IQR]) (15.5 [13.5-15.5] years). Thirty-six healthy individuals with normal serum uric acid level were selected as a reference group. Additionally, the study group with hyperuricemia was divided into two groups: HU-HT (hypertensive n=25) and HU-NT (normotensive n=28) teenagers. The serum concentration of human sRAGE was measured using a commercially available enzyme-linked immunosorbent assay (ELISA) kit.
   Results: We found statistically significant differences in serum sRAGE levels between normotensive subjects with hyperuricemia (median [IQR]) (169.8 [148.3-231.1] pg/ml) and reference group (median [IQR]) (129 [107.4-175.3] pg/ml), p<0.01. Univariate analysis of the data revealed a positive correlation between serum sRAGE and serum uric acid in the study group (r=0.306, p<0.05).
   Conclusion: Our data showed that serum soluble receptors for AGEs are increased in teenagers with hyperuricemia. In contrast, neither hypertension nor increased BMI had a significant influence on serum sRAGE concentration. Further studies are needed to discover the possible mechanism on the influence of uric acid on sRAGE levels and to assess its possible clinical significance.
C1 [Lemiesz, Marta; Tenderenda-Banasiuk, Edyta; Rybi-Szumniska, Agnieszka; Storonowicz, Justyna; Wasilewska, Anna] Med Univ Bialystok, Dept Pediat & Nephrol, 17 Waszyngtona St, PL-15274 Bialystok, Poland.
   [Sosnowska, Dorota] Med Hosp Garwolin, Dept Obstet Gynecol, Garwolin, Poland.
   [Lemiesz, Tomasz] Hosp Minist Interior & Adm Bialystok, Dept Gen Surg & Urol, Bialystok, Poland.
C3 Medical University of Bialystok
RP Lemiesz, T (corresponding author), Med Univ Bialystok, Dept Pediat & Nephrol, 17 Waszyngtona St, PL-15274 Bialystok, Poland.
EM me.pszczolkowska@gmail.com
RI Dorota, Sosnowska/M-4286-2018; Rybi'Szuminska, Agnieszka/LDF-9057-2024
OI Rybi Szuminska, Agnieszka Anna/0000-0002-5329-6330
FU Medical University of Bialystok [157-35652L]
FX Special thanks to Professor Neil R. M. Buist for his advice and
   confidence in our work. Funding for this research was provided by the
   Medical University of Bialystok (157-35652L). The sponsor had no
   involvement in study design and interpretation of data.
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NR 46
TC 1
Z9 1
U1 0
U2 4
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1381-6128
EI 1873-4286
J9 CURR PHARM DESIGN
JI Curr. Pharm. Design
PY 2018
VL 24
IS 27
BP 3232
EP 3239
DI 10.2174/1381612824666180813114127
PG 8
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA HC5OT
UT WOS:000451853000010
PM 30101695
DA 2025-06-11
ER

PT J
AU Mikusic, NLR
   Kouyoumdzian, NM
   Del Mauro, JS
   Cao, G
   Trida, V
   Gironacci, MM
   Puyó, AM
   Toblli, JE
   Fernández, BE
   Choi, MR
AF Mikusic, Natalia L. Rukavina
   Kouyoumdzian, Nicolas M.
   Del Mauro, Julieta S.
   Cao, Gabriel
   Trida, Veronica
   Gironacci, Mariela M.
   Puyo, Ana M.
   Toblli, Jorge E.
   Fernandez, Belisario E.
   Choi, Marcelo R.
TI Effects of chronic fructose overload on renal dopaminergic system:
   alteration of urinary L-dopa/dopamine index correlates to hypertension
   and precedes kidney structural damage
SO JOURNAL OF NUTRITIONAL BIOCHEMISTRY
LA English
DT Article
DE Dopamine; Fructose; Hypertension; Insulin resistance; Na+; K+-ATPase;
   Microalbuminuria
ID ORGANIC CATION TRANSPORTERS; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   OXIDATIVE STRESS; SODIUM; HOMEOSTASIS; DYSFUNCTION; EXPRESSION; GLUCOSE;
   LIVER
AB Insulin resistance induced by a high-fructose diet has been associated to hypertension and renal damage. The aim of this work was to assess alterations in the urinary L-dopa/dopamine ratio over three time periods in rats with insulin resistance induced by fructose overload and its correlation with blood pressure levels and the presence of microalbuminuria and reduced nephrin expression as markers of renal structural damage. Male Sprague Dawley rats were randomly divided into six groups: control (C) (C4, C8 and C12) with tap water to drink and fructose-overloaded (FO) rats (FO4, FO8 and FO12) with a fructose solution (10% w/v) to drink for 4, 8 and 12 weeks. A significant increase of the urinary L-dopa/dopamine ratio was found in FO rats since week 4, which positively correlated to the development of hypertension and preceded in time the onset of microalbuminuria and reduced nephrin expression observed on week 12 of treatment. The alteration of this ratio was associated to an impairment of the renal dopaminergic system, evidenced by a reduction in renal dopamine transporters and dopamine D1 receptor expression, leading to an overexpression and overactivation of the enzyme Na+, K+-ATPase with sodium retention. In conclusion, urinary L-dopa/dopamine ratio alteration in rats with fructose overload positively correlated to the development of hypertension and preceded in time the onset of renal structural damage. This is the first study to propose the use of the urinary L-dopa/dopamine index as marker of renal dysfunction that temporarily precedes kidney structural damage induced by fructose overload. (C) 2017 Elsevier Inc. All rights reserved.
C1 [Mikusic, Natalia L. Rukavina; Kouyoumdzian, Nicolas M.; Cao, Gabriel; Toblli, Jorge E.; Fernandez, Belisario E.; Choi, Marcelo R.] Univ Buenos Aires, Inst Invest Cardiol ININCA, CONICET, Marcelo T de Alvear 2270,C1122AAJ CABA, Buenos Aires, DF, Argentina.
   [Mikusic, Natalia L. Rukavina; Kouyoumdzian, Nicolas M.; Trida, Veronica; Puyo, Ana M.; Fernandez, Belisario E.; Choi, Marcelo R.] Univ Buenos Aires, Inst Fisiopatol & Bioquim Clin INFIBIOC, Junin 956,C1113AAD CABA, Buenos Aires, DF, Argentina.
   [Del Mauro, Julieta S.] Univ Buenos Aires, Fac Farm & Bioquim, Dept Farmacol, Catedra Farmacol, Junin 956,C1113AAD CABA, Buenos Aires, DF, Argentina.
   [Cao, Gabriel; Toblli, Jorge E.] Hosp Aleman, Lab Med Expt, Pueyrredon 1640,C1118AAT CABA, Buenos Aires, DF, Argentina.
   [Gironacci, Mariela M.] Univ Buenos Aires, Fac Farm & Bioquim, Dept Quim Biol, Catedra Quim Biol, Junin 956,C1113AAD CABA, Buenos Aires, DF, Argentina.
   [Puyo, Ana M.; Choi, Marcelo R.] Univ Buenos Aires, Fac Farm & Bioquim, Dept Ciencias Biol, Catedra Anat & Histol, Junin 956,C1113AAD CABA, Buenos Aires, DF, Argentina.
   [Fernandez, Belisario E.] Inst Univ Ciencias Salud, Fdn HA Barcelo, Av Gral Las Heras 2191,C1127AAD CABA, Buenos Aires, DF, Argentina.
C3 University of Buenos Aires; Consejo Nacional de Investigaciones
   Cientificas y Tecnicas (CONICET); University of Buenos Aires; University
   of Buenos Aires; Hospital Aleman; University of Buenos Aires; University
   of Buenos Aires Hospital; University of Buenos Aires; University of
   Buenos Aires
RP Mikusic, NLR (corresponding author), Univ Buenos Aires, Inst Invest Cardiol ININCA, CONICET, Marcelo T de Alvear 2270,C1122AAJ CABA, Buenos Aires, DF, Argentina.
EM naty_rkv@hotmail.com
RI Choi, Marcelo/I-4082-2019; Cao, Gabriel/LJL-8755-2024
OI Gironacci, Mariela/0000-0002-8189-0388; Choi,
   Marcelo/0000-0003-2909-8534
FU ANPCYT [PICT 2012-1775]; Universidad de Buenos Aires [UBACYT
   20020110200048, 200201302001058A]; Sociedad Argentina de Hipertension
   Arterial (Stimulus Grant for Research on Hypertension)
FX This work was supported by grants from the ANPCYT (PICT 2012-1775),
   Universidad de Buenos Aires (UBACYT 20020110200048 and 200201302001058A)
   and Sociedad Argentina de Hipertension Arterial (Stimulus Grant for
   Research on Hypertension 2014-2015).
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NR 39
TC 11
Z9 11
U1 2
U2 14
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0955-2863
EI 1873-4847
J9 J NUTR BIOCHEM
JI J. Nutr. Biochem.
PD JAN
PY 2018
VL 51
BP 47
EP 55
DI 10.1016/j.jnutbio.2017.09.005
PG 9
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA FQ2RU
UT WOS:000418205800006
PM 29091814
OA Green Published
DA 2025-06-11
ER

PT J
AU Carnevale, R
   Pastori, D
   Nocella, C
   Cammisotto, V
   Baratta, F
   Del Ben, M
   Angelico, F
   Sciarretta, S
   Bartimoccia, S
   Novo, M
   Targher, G
   Violi, F
AF Carnevale, R.
   Pastori, D.
   Nocella, C.
   Cammisotto, V.
   Baratta, F.
   Del Ben, M.
   Angelico, F.
   Sciarretta, S.
   Bartimoccia, S.
   Novo, M.
   Targher, G.
   Violi, F.
TI Low-grade endotoxemia, gut permeability and platelet activation in
   patients with impaired fasting glucose
SO NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
LA English
DT Article
DE Lipopolysaccharide; Oxidized low density lipoprotein; Platelet
   activation; P-selectin; Zonulin
ID SOLUBLE P-SELECTIN; DIABETES-MELLITUS; INTESTINAL PERMEABILITY;
   MYOCARDIAL-INFARCTION; METABOLIC SYNDROME; DISEASE; ATHEROSCLEROSIS;
   HYPERGLYCEMIA; EPIDEMIOLOGY; PNEUMONIA
AB Background and aim: Impaired fasting glucose (IFG) is associated with an increased risk of cardiovascular disease but the underlying mechanisms are still unclear. Aim of the study was to investigate the interplay between platelet activation, lipopolysaccharides (LPS) and markers of oxidative stress in patients with IFG and control subjects.
   Methods and results: We performed a cross-sectional study including 35 patients with IFG and 35 control subjects who were well comparable for age, sex, body mass index and smoking history. Serum levels of LPS, zonulin (a marker of gut permeability), oxidized LDL and plasma levels of soluble P-selectin, were measured. Patients with IFG had significantly higher levels of sP-selectin, LPS, zonulin and oxLDL compared to control subjects.
   The IFG status (beta coefficient: 0.518, p < 0.001), higher LPS (beta coefficient: 0.352, p = 0.001) and female sex (beta coefficient: 0.179, p = 0.042) were independently associated with higher sP-selectin; in addition, oxLDL was positively associated with sP-selectin (r = 0.530, p < 0.001) and LPS (r = 0.529, p = 0.001). In IFG patients, we found a significant association between LPS and zonulin (r = 0.521, p = 0.001); this association was confirmed at multivariable analysis (beta coefficient: 0.512, p = 0.007).
   Conclusion: Our study provides evidence that patients with IFG have increased platelet activation, and suggests LPS as a potential trigger for in vivo platelet activation in this patient population. (C) 2017 Published by Elsevier B.V. on behalf of The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University.
C1 [Carnevale, R.; Nocella, C.; Sciarretta, S.] Sapienza Univ Rome, Dept Med Surg Sci & Biotechnol, Latina, Italy.
   [Pastori, D.; Cammisotto, V.; Baratta, F.; Del Ben, M.; Angelico, F.; Bartimoccia, S.; Novo, M.; Violi, F.] Sapienza Univ Rome, Dept Internal Med & Med Specialties, Atherothrombosis Ctr, Med Clin 1, Rome, Italy.
   [Targher, G.] Univ Verona, Sect Endocrinol Diabet & Metab, Dept Med, Verona, Italy.
   [Pastori, D.; Baratta, F.] Sapienza Univ Rome, Dept Anat Histol Forens Med & Orthoped Sci, Rome, Italy.
C3 Sapienza University Rome; Sapienza University Rome; University of
   Verona; Sapienza University Rome
RP Violi, F (corresponding author), Sapienza Univ Rome, Med Clin 1, Viale Policlin 155, I-00161 Rome, Italy.
EM francesco.violi@uniroma1.it
RI Nocella, Cristina/K-2175-2016; Carnevale, Roberto/JMC-1138-2023; Del
   Ben, Maria/AAE-7603-2020; Angelico, Francesco/AAB-6585-2020; Violi,
   Francesco/K-1509-2016; Targher, Giovanni/AAB-9008-2019; Cammisotto,
   Vittoria/W-5910-2019; Sciarretta, Sebastiano/K-5161-2016; Bartimoccia,
   Simona/K-7873-2016; pastori, daniele/J-7087-2016
OI Sciarretta, Sebastiano/0000-0002-8633-6896; Bartimoccia,
   Simona/0000-0002-6266-3059; Targher, Giovanni/0000-0002-4325-3900;
   Baratta, Francesco/0000-0003-1708-272X; pastori,
   daniele/0000-0001-6357-5213
CR Aravindhan V, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0137618
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NR 24
TC 22
Z9 23
U1 0
U2 6
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0939-4753
EI 1590-3729
J9 NUTR METAB CARDIOVAS
JI Nutr. Metab. Carbiovasc. Dis.
PD OCT
PY 2017
VL 27
IS 10
BP 890
EP 895
DI 10.1016/j.numecd.2017.06.007
PG 6
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism; Nutrition
   & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism;
   Nutrition & Dietetics
GA FL9AG
UT WOS:000414542000007
PM 28743559
DA 2025-06-11
ER

PT J
AU Nakamura, K
   Sakurai, M
   Morikawa, Y
   Nagasawa, SY
   Miura, K
   Ishizaki, M
   Kido, T
   Naruse, Y
   Nakashima, M
   Nogawa, K
   Suwazono, Y
   Nakagawa, H
AF Nakamura, Koshi
   Sakurai, Masaru
   Morikawa, Yuko
   Nagasawa, Shin-ya
   Miura, Katsuyuki
   Ishizaki, Masao
   Kido, Teruhiko
   Naruse, Yuchi
   Nakashima, Motoko
   Nogawa, Kazuhiro
   Suwazono, Yasushi
   Nakagawa, Hideaki
TI Serum Ferritin, Insulin Resistance, and β-cell Dysfunction: A
   Prospective Study in Normoglycemic Japanese Men
SO EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
LA English
DT Article
DE serum ferritin; homeostasis model assessment; insulin resistance;
   beta-cell dysfunction; epidemiology; prospective study
ID C-REACTIVE PROTEIN; BODY IRON STORES; OXIDATIVE STRESS; METABOLIC
   SYNDROME; DIABETES-MELLITUS; SYNDROME DESIR; WOMEN; ASSOCIATION;
   TRANSFERRIN; GLUCOSE
AB Objectives: The present cohort study investigated the relationship between serum ferritin levels and indices of insulin resistance and beta-cell dysfunction in a normoglycemic population without iron overload disorders.
   Methods: The study participants included 575 normoglycemic Japanese men aged 35-57 years with serum ferritin levels of 400 mu g/L or less. Insulin resistance and beta-cell dysfunction were estimated at baseline and after 3 years by the homeostasis model assessments of insulin resistance and beta-cell function (HOMA-IR and HOMA-beta, respectively). To compare the subsequent changes in HOMA-IR and HOMA-beta over a 3-year follow-up period among 3 groups based on tertiles of baseline serum ferritin levels (4.9-87.1, 87.2-140.5, and 140.6-396.8 mu g/L), the geometric mean HOMA-IR and HOMA-beta values at year 3 were calculated for each group using analysis of covariance, incorporating the respective log-transformed parameters at baseline in addition to age, body mass index and major confounding factors.
   Results: The multivariate-adjusted geometric mean HOMA-IR at year 3 was significantly higher in those in the highest and middle serum ferritin tertiles (1.24 and 1.22, respectively), compared with the lowest tertile (1.07) (p = 0.009). When the total study participants were stratified by median body mass index (22.72 kg/m(2)), similar positive relationships were observed between serum ferritin levels and HOMA-IR for both obese and non-obese participants. However, the adjusted geometric mean HOMA-beta at year 3 was similar among the 3 serum ferritin groups.
   Conclusions: Elevated serum ferritin levels predicted a subsequent increase in HOMA-IR in normoglycemic Japanese men without iron overload disorders.
C1 [Nakamura, Koshi] Hokkaido Univ, Grad Sch Med, Dept Publ Hlth, Sapporo, Hokkaido, Japan.
   [Nakamura, Koshi; Nagasawa, Shin-ya] Kanazawa Med Univ, Dept Epidemiol & Publ Hlth, Uchinada, Ishikawa, Japan.
   [Sakurai, Masaru; Ishizaki, Masao] Kanazawa Med Univ, Dept Social & Environm Med, Uchinada, Ishikawa, Japan.
   [Morikawa, Yuko; Nakashima, Motoko] Kanazawa Med Univ, Sch Nursing, Uchinada, Ishikawa, Japan.
   [Miura, Katsuyuki] Shiga Univ Med Sci, Dept Publ Hlth, Otsu, Shiga, Japan.
   [Miura, Katsuyuki] Shiga Univ Med Sci, Ctr Epidemiol Res Asia, Otsu, Shiga, Japan.
   [Kido, Teruhiko] Kanazawa Univ, Coll Med Pharmaceut & Hlth Sci, Sch Hlth Sci, Kanazawa, Ishikawa, Japan.
   [Naruse, Yuchi] Toyama Coll Welf Sci, Dept Social Walfare, Imizu, Toyama, Japan.
   [Nogawa, Kazuhiro; Suwazono, Yasushi] Chiba Univ, Grad Sch Med, Dept Occupat & Environm Med, Chiba, Japan.
   [Nakagawa, Hideaki] Kanazawa Med Univ, Med Res Inst, Uchinada, Ishikawa, Japan.
C3 Hokkaido University; Kanazawa Medical University; Kanazawa Medical
   University; Kanazawa Medical University; Shiga University of Medical
   Science; Shiga University of Medical Science; Kanazawa University; Chiba
   University; Kanazawa Medical University
RP Nakamura, K (corresponding author), Hokkaido Univ, Grad Sch Med, Dept Publ Hlth, Kita Ku, Kita 15 Nishi 7, Sapporo, Hokkaido 0608638, Japan.
EM koshi.nakamura@med.hokudai.ac.jp
RI NISHI, NOBUO/S-6195-2019; Sakurai, Masaru/AAC-6551-2021
OI Miura, Katsuyuki/0000-0002-2646-9582
FU Japan Society for the Promotion of Science [23590817, 26460850];
   Ministry of Health, Labour and Welfare, Japan [H17-Kenkou-007,
   H18-Junkankitou [Seishuu]-Ippan-012, H19-Junkankitou
   [Seishuu]-Ippan-021, H20-Junkankitou [Seishuu]-Ippan-013,
   H22-Junkankitou [Seishuu]-Ippan-005, H23-Junkankitou
   [Seishuu]-Ippan-005, H26-Junkankitou [Seisaku]-Ippan-001]; Japan
   Arteriosclerosis Prevention Fund; Grants-in-Aid for Scientific Research
   [23590817, 26460850] Funding Source: KAKEN
FX The study was supported by a Grant-in-Aid from the Japan Society for the
   Promotion of Science (Scientific Research (C) 23590817 and Scientific
   Research (C) 26460850); from the Ministry of Health, Labour and Welfare,
   Japan (H17-Kenkou-007, H18-Junkankitou [Seishuu]-Ippan-012,
   H19-Junkankitou [Seishuu]-Ippan-021, H20-Junkankitou
   [Seishuu]-Ippan-013, H22-Junkankitou [Seishuu]-Ippan-005,
   H23-Junkankitou [Seishuu]-Ippan-005 and H26-Junkankitou
   [Seisaku]-Ippan-001); and from the Japan Arteriosclerosis Prevention
   Fund.
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NR 41
TC 6
Z9 8
U1 0
U2 6
PU JOHANN AMBROSIUS BARTH VERLAG MEDIZINVERLAGE HEIDELBERG GMBH
PI STUTTGART
PA RUEDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0947-7349
EI 1439-3646
J9 EXP CLIN ENDOCR DIAB
JI Exp. Clin. Endocrinol. Diabet.
PD JAN
PY 2017
VL 125
IS 1
BP 12
EP 20
DI 10.1055/s-0042-118175
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA EK4LZ
UT WOS:000393899600002
PM 27750351
DA 2025-06-11
ER

PT J
AU Santamarina, AB
   Carvalho-Silva, M
   Gomes, LM
   Okuda, MH
   Santana, AA
   Streck, EL
   Seelaender, M
   do Nascimento, CMO
   Ribeiro, EB
   Lira, FS
   Oyama, LM
AF Santamarina, Aline B.
   Carvalho-Silva, Milena
   Gomes, Lara M.
   Okuda, Marcos H.
   Santana, Aline A.
   Streck, Emilio L.
   Seelaender, Marilia
   Oller do Nascimento, Claudia M.
   Ribeiro, Eliane B.
   Lira, Fabio S.
   Oyama, Lila Missae
TI Decaffeinated green tea extract rich in epigallocatechin-3-gallate
   prevents fatty liver disease by increased activities of mitochondrial
   respiratory chain complexes in diet-induced obesity mice
SO JOURNAL OF NUTRITIONAL BIOCHEMISTRY
LA English
DT Article
DE EGCG; NAFLD; Obesity; Mice; Respiratory chain; Insulin resistance
ID INSULIN-RESISTANCE; OXIDATIVE STRESS; METABOLIC SYNDROME; MECHANISMS;
   INFLAMMATION; CAPACITY; MODEL; (-)-EPIGALLOCATECHIN-3-GALLATE;
   SUPPLEMENTATION; ACCUMULATION
AB Nonalcoholic fatty liver disease has been considered the hepatic manifestation of obesity. It is unclear whether supplementation with green tea extract rich in epigallocatechin-3-gallate (EGCG) influences the activity of mitochondrial respiratory chain complexes and insulin resistance in the liver. EGCG regulated hepatic mitochondrial respiratory chain complexes and was capable of improving lipid metabolism, attenuating insulin resistance in obese mice. Mice were divided into four groups: control diet+water (CW) or EGCG (CE) and hyperlipidic diet+water (HFW) or EGCG (HFE). All animals received water and diets ad libitum for 16 weeks. Placebo groups received water (0.1 ml/day) and EGCG groups (0.1 ml EGCG and 50 mg/kg/day) by gavage. Cytokines concentrations were obtained by EUSA, protein expression through Western blotting and mitochondrial complex enzymatic activity by calorimetric assay of substrate degradation. HFW increased body weight gain, adiposity index, retroperitoneal and mesenteric adipose tissue relative weight, serum glucose, insulin and Homeostasis Model Assessment of Basal Insulin Resistance (HOMA-IR); glucose intolerance was observed in oral glucose tolerance test (OGTT) as well as ectopic fat liver deposition. HFE group decreased body weight gain, retroperitoneal and mesenteric adipose tissue relative weight, HOMA-IR, insulin levels and liver fat accumulation; increased complexes II-III and IV and malate dehydrogenase activities and improvement in glucose uptake in OGTT and insulin sensitivity by increased protein expression of total AKT, IR alpha and IRS1. We did not find alterations in inflammatory parameters analyzed. EGCG was able to prevent obesity stimulating the mitochondrial complex chain, increasing energy expenditure, particularly from the oxidation of lipid substrates, thereby contributing to the prevention of hepatic steatosis and improved insulin sensitivity. (C) 2015 Elsevier Inc. All rights reserved.
C1 [Santamarina, Aline B.; Okuda, Marcos H.; Santana, Aline A.; Oller do Nascimento, Claudia M.; Ribeiro, Eliane B.; Oyama, Lila Missae] Univ Fed Sao Paulo, Dept Fisiol, BR-04021001 Sao Paulo, SP, Brazil.
   [Carvalho-Silva, Milena; Gomes, Lara M.; Streck, Emilio L.] Univ Extremo Sul Catarinense, Programa Posgrad Ciencia Saude, BR-88806000 Criciuma, SC, Brazil.
   [Seelaender, Marilia] Univ Sao Paulo, Inst Biomed Sci, Canc Metab Res Grp, BR-05508000 Sao Paulo, SP, Brazil.
   [Lira, Fabio S.] Univ Estadual Paulista, Dept Phys Educ, Exercise & Immunometab Res Grp, BR-19060900 Presidente Prudente, SP, Brazil.
C3 Universidade Federal de Sao Paulo (UNIFESP); Universidade do Extremo Sul
   Catarinense; Universidade de Sao Paulo; Universidade Estadual Paulista
RP Oyama, LM (corresponding author), Univ Fed Sao Paulo, Dept Fisiol, Rua Botucatu,862 Vila Clementino, BR-04023062 Sao Paulo, SP, Brazil.
EM lmoyama@gmail.com
RI Streck, Emilio/J-7558-2013; do Nascimento, Claudia/T-4151-2019;
   seelaender, marilia/B-9101-2011; Santamarina, Aline/AAI-7639-2020;
   Ribeiro, Eliane/C-8124-2012; Gomes, Lara/LCE-0960-2024; Oyama,
   Lila/B-7609-2012; Lira, Fabio/Q-7581-2016
OI Seelaender, Marilia/0000-0002-9999-8020; Lira, Fabio/0000-0002-9645-1003
FU Conselho Nacional de Desenvolvimento Cientifico e Tecnologico; Fundacao
   de Amparo a Pesquisa do Estado de Sao Paulo [2014/19508-7]; Coordenacao
   de Aperfeicoamento de Pessoal de Nivel Superior; Fundacao de Amparo a
   Pesquisa do Estado de Sao Paulo (FAPESP) [14/19508-7] Funding Source:
   FAPESP
FX This work was supported by Conselho Nacional de Desenvolvimento
   Cientifico e Tecnologico, Fundacao de Amparo a Pesquisa do Estado de Sao
   Paulo (2014/19508-7) and Coordenacao de Aperfeicoamento de Pessoal de
   Nivel Superior.
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NR 62
TC 68
Z9 77
U1 2
U2 54
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0955-2863
EI 1873-4847
J9 J NUTR BIOCHEM
JI J. Nutr. Biochem.
PD NOV
PY 2015
VL 26
IS 11
BP 1348
EP 1356
DI 10.1016/j.jnutbio.2015.07.002
PG 9
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA CW4RK
UT WOS:000364979600025
PM 26300331
OA Green Published
DA 2025-06-11
ER

PT J
AU Mailloux, R
   Fu, A
   Florian, M
   Petrov, I
   Chen, QX
   Coughlan, MC
   Laziyan, M
   Yan, J
   Caldwell, D
   Patry, D
   Lalande, M
   Wang, GS
   Willmore, W
   Jin, XL
AF Mailloux, Ryan
   Fu, Accalia
   Florian, Maria
   Petrov, Ivan
   Chen, Qixuan
   Coughlan, Melanie C.
   Laziyan, Mahemuti
   Yan, Jin
   Caldwell, Don
   Patry, Dominique
   Lalande, Michelle
   Wang, Gen-Sheng
   Willmore, William
   Jin, Xiaolei
TI A Northern contaminant mixture impairs pancreas function in obese and
   lean JCR rats and inhibits insulin secretion in MIN6 cells
SO TOXICOLOGY
LA English
DT Article
DE Northern contaminant mixture; Pancreas; Insulin; Obese and lean JCR
   rats; MIN6 cells; beta cells
ID PERSISTENT ORGANIC POLLUTANTS; METABOLIC SYNDROME; PERFLUOROOCTANE
   SULFONATE; MITOCHONDRIAL DYSFUNCTION; EPIDEMIOLOGIC EVIDENCE;
   GLUCOSE-HOMEOSTASIS; LIVER-DISEASE; 1ST NATIONS; ASSOCIATION; POPULATION
AB Rates of obesity and diabetes mellitus of Arctic populations are increasing due to multiple reasons including a departure from traditional lifestyles and alcohol consumption patterns. These populations are also exposed to a variety of anthropogenic contaminants through consumption of contaminated country foods. We have previously shown that a Northern contaminant mixture (NCM), containing 22 organic and inorganic contaminants found in the blood of Canadian Arctic populations, induces endothelial cell dysfunction and exacerbates development of non-alcoholic fatty liver disease in experimental models. In order to determine if these contaminants affect pancreas function and physiology and if obesity and alcohol can influence contaminant toxicity and the development of diabetes, lean and obese JCR rats were orally treated with NCM at 0 (vehicle), 1.6 or 16 mg/kg BW for four weeks in the presence or absence of 10% (v/v) alcohol. NCM treatment altered islet morphology, increased iron deposit in pancreas, and reduced circulating and pancreatic insulin levels and circulating glucagon levels as a result of direct islet injury with beta and alpha cell loss with or without exposure to alcohol. Studies conducted with cultured mouse insulin-secreting (MIN6) beta cells further demonstrated that NCM inhibited insulin release and induced cell death through oxidative stress and mitochondrial dysfunction. 2,3,4,6-Tetrabromophenol, a minor component of the NCM, alone also inhibited insulin release from MIN6 cells after 10 min of exposure. These results suggest that Northern contaminants may contribute to pancreatic dysfunction, and possibly development of diabetes, in some of the highly exposed Arctic populations. The implications and relevance of these findings to Northern populations remains to be confirmed through epidemiological studies. Crown Copyright (C) 2015 Published by Elsevier Ireland Ltd. All rights reserved.
C1 [Mailloux, Ryan; Fu, Accalia; Florian, Maria; Petrov, Ivan; Chen, Qixuan; Coughlan, Melanie C.; Laziyan, Mahemuti; Yan, Jin; Jin, Xiaolei] Hlth Canada, Regulatory Toxicol Res Div, Bur Chem Safety, Food Directorate, Ottawa, ON K1A 0K9, Canada.
   [Mailloux, Ryan; Fu, Accalia; Florian, Maria; Laziyan, Mahemuti; Willmore, William] Carleton Univ, Inst Biochem, Dept Biol, Ottawa, ON K1S 5B6, Canada.
   [Caldwell, Don; Patry, Dominique; Lalande, Michelle; Wang, Gen-Sheng] Hlth Canada, Bur Chem Safety, Sci Serv Div, Ottawa, ON K1A 0K9, Canada.
C3 Health Canada; Carleton University; Health Canada
RP Jin, XL (corresponding author), PL2202C,251 Sir Frederick Banting Driveway, Ottawa, ON K1A 0K9, Canada.
EM dawn.jin@hc-sc.gc.ca
RI Wang, Gloria/KHE-1618-2024; Mailloux, Ryan/NES-4343-2025
OI Fu, Accalia/0000-0002-1110-8039; Mailloux, Ryan/0000-0003-3986-9830
FU Northern Contaminants Program (NCP); multidisciplinary initiative of the
   Government of Canada; Regulatory Toxicology Research Division, Bureau of
   Chemical Safety, Food Directorate, Health Canada; Natural Sciences and
   Engineering Research Council (NSERC) of Canada
FX This work was supported by a grant from the Northern Contaminants
   Program (NCP), a multidisciplinary initiative of the Government of
   Canada, and the Regulatory Toxicology Research Division, Bureau of
   Chemical Safety, Food Directorate, Health Canada, to XJ and a Discovery
   Grant from the Natural Sciences and Engineering Research Council (NSERC)
   of Canada to WGW.
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NR 53
TC 13
Z9 13
U1 1
U2 14
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0300-483X
J9 TOXICOLOGY
JI Toxicology
PD AUG 6
PY 2015
VL 334
BP 81
EP 93
DI 10.1016/j.tox.2015.06.001
PG 13
WC Pharmacology & Pharmacy; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Toxicology
GA CN4IC
UT WOS:000358392800008
PM 26066519
DA 2025-06-11
ER

PT J
AU Nduhirabandi, F
   Huisamen, B
   Strijdom, H
   Blackhurst, D
   Lochner, A
AF Nduhirabandi, Frederic
   Huisamen, Barbara
   Strijdom, Hans
   Blackhurst, Dee
   Lochner, Amanda
TI Short-term melatonin consumption protects the heart of obese rats
   independent of body weight change and visceral adiposity
SO JOURNAL OF PINEAL RESEARCH
LA English
DT Article
DE cardioprotection; insulin resistance; intracellular signalling;
   melatonin; myocardial ischaemia-reperfusion injury; obesity
ID ISCHEMIA-REPERFUSION INJURY; METABOLIC SYNDROME; OXIDATIVE STRESS;
   MYOCARDIAL-INFARCTION; PREDIABETIC MODEL; PLASMA-LEVELS; INSULIN;
   IMPROVES; YOUNG; ACTIVATION
AB Chronic melatonin treatment has been shown to prevent the harmful effects of diet-induced obesity and reduce myocardial susceptibility to ischaemia-reperfusion injury (IRI). However, the exact mechanism whereby it exerts its beneficial actions on the heart in obesity/insulin resistance remains unknown. Herein, we investigated the effects of relatively short-term melatonin treatment on the heart in a rat model of diet-induced obesity. Control and diet-induced obese Wistar rats (fed a high calorie diet for 20 wk) were each subdivided into three groups receiving drinking water with or without melatonin (4 mg/kg/day) for the last 6 or 3 wk of experimentation. A number of isolated hearts were perfused in the working mode, subjected to regional or global ischaemia-reperfusion; others were nonperfused. Metabolic parameters, myocardial infarct sizes (IFS), baseline and postischaemic activation of PKB/Akt, ERK42/44, GSK-3 beta and STAT-3 were determined. Diet-induced obesity caused increases in body weight gain, visceral adiposity, fasting blood glucose, serum insulin and triglyceride (TG) levels with a concomitant cardiac hypertrophy, large postischaemic myocardial IFSs and a reduced cardiac output. Melatonin treatment (3 and 6 wk) decreased serum insulin levels and the HOMA index (P < 0.05) with no effect on weight gain (after 3 wk), visceral adiposity, serum TG and glucose levels. It increased serum adiponectin levels, reduced myocardial IFSs in both groups and activated baseline myocardial STAT-3 and PKB/Akt, ERK42/44 and GSK-3b during reperfusion. Overall, short-term melatonin administration to obese/insulin resistant rats reduced insulin resistance and protected the heart against ex vivo myocardial IRI independently of body weight change and visceral adiposity.
C1 [Nduhirabandi, Frederic; Huisamen, Barbara; Strijdom, Hans; Lochner, Amanda] Univ Stellenbosch, Div Med Physiol, Dept Biomed Sci, Fac Med & Hlth Sci, ZA-7600 Stellenbosch, South Africa.
   [Blackhurst, Dee] Univ Cape Town, Dept Med, Fac Hlth Sci, Div Lipidol, ZA-7925 Cape Town, South Africa.
C3 Stellenbosch University; University of Cape Town
RP Nduhirabandi, F (corresponding author), Fac Med & Hlth Sci, Div Med Physiol, Dept Biomed Sci, POB 19063, ZA-7505 Tygerberg, South Africa.
EM frederic.nduhirabandi@uct.ac.za
RI Nduhirabandi, Frederic/M-6274-2018
OI Strijdom, Hans/0000-0003-3726-9153; Nduhirabandi,
   Frederic/0000-0002-0428-1220
FU South African National Research Fundation; Harry Crossley Foundation
FX This study was supported by the South African National Research
   Fundation and Harry Crossley Foundation.
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NR 71
TC 41
Z9 42
U1 0
U2 11
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0742-3098
EI 1600-079X
J9 J PINEAL RES
JI J. Pineal Res.
PD OCT
PY 2014
VL 57
IS 3
BP 317
EP 332
DI 10.1111/jpi.12171
PG 16
WC Endocrinology & Metabolism; Neurosciences; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Physiology
GA AP7CF
UT WOS:000342234600008
PM 25187154
DA 2025-06-11
ER

PT J
AU Ahn, HR
   Shin, MH
   Nam, HS
   Park, KS
   Lee, YH
   Jeong, SK
   Choi, JS
   Kweon, SS
AF Ahn, Hye-Ran
   Shin, Min-Ho
   Nam, Hae-Sung
   Park, Kyeong-Soo
   Lee, Young-Hoon
   Jeong, Seul-Ki
   Choi, Jin-Su
   Kweon, Sun-Seog
TI The association between liver enzymes and risk of type 2 diabetes: the
   Namwon study
SO DIABETOLOGY & METABOLIC SYNDROME
LA English
DT Article
DE Chronic disease; Diabetes; Epidemiology
ID GAMMA-GLUTAMYL-TRANSFERASE; C-REACTIVE PROTEIN; MIDDLE-AGED MEN;
   SCOTLAND CORONARY PREVENTION; IMPAIRED FASTING GLUCOSE; METABOLIC
   SYNDROME; INSULIN-RESISTANCE; ALANINE AMINOTRANSFERASE; OXIDATIVE
   STRESS; FOLLOW-UP
AB Background: We examined the association between liver enzymes and development of type 2 diabetes in a general Korean population.
   Methods: A total of 10,667 subjects (4,201 males and 6,466 females) aged 45 to 74 years participated in a baseline examination between 2004 and 2007. Among the subjects, 8,157 (3,231 males and 4,926 females) underwent follow-up examination from 2007 to 2011, for a median follow-up period of 4.2 years. Type 2 diabetes was defined as intake of anti-diabetic agents, insulin treatment, fasting glucose concentration of more than 126 mg/dl, or hemoglobin A1c of more than 6.5% at re-examination. Associations of liver enzymes with incidence of type 2 diabetes were analyzed using logistic regression models.
   Results: During the follow-up period, 548 subjects (235 males, 313 females) developed type 2 diabetes. After adjusting for comprehensive diabetes risk factor, the risk of type 2 diabetes was significantly higher in the highest alanine aminotransferase (ALT) quartile than in the lowest quartile (odds ratio (OR): 1.95, 95% confidence interval (CI): 1.18-3.21 in males; OR: 1.49, 95% CI: 1.03-2.16 in females). Similar results were observed for gamma-glutamyltransferase (GGT) quartiles, but in the fully adjusted analysis, the OR for the highest versus lowest quartiles was significant only for females (OR: 1.58, 95% CI: 0.95-2.63 in males; OR: 1.85, 95% CI: 1.23-2.79 in females).
   Conclusions: Our results suggest that serum ALT concentrations were independently associated with type 2 diabetes in both sexes, and that GGT was also independently associated but only in females.
C1 [Ahn, Hye-Ran; Shin, Min-Ho; Choi, Jin-Su; Kweon, Sun-Seog] Chonnam Natl Univ, Sch Med, Dept Prevent Med, Kwangju 501746, South Korea.
   [Nam, Hae-Sung] Chungnam Natl Univ, Sch Med, Dept Prevent Med & Publ Hlth, Taejon, South Korea.
   [Park, Kyeong-Soo] Seonam Univ, Coll Med, Dept Prevent Med, Namwon, South Korea.
   [Lee, Young-Hoon] Wonkwang Univ, Sch Med, Dept Prevent Med, Iksan, South Korea.
   [Lee, Young-Hoon] Wonkwang Univ, Sch Med, Inst Wonkwang Med Sci, Iksan, South Korea.
   [Jeong, Seul-Ki] Chonbuk Natl Univ, Sch Med, Dept Neurol, Jeonju, South Korea.
   [Jeong, Seul-Ki] Chonbuk Natl Univ, Sch Med, Res Inst Clin Med, Jeonju, South Korea.
   [Jeong, Seul-Ki] Chonbuk Natl Univ Hosp, Jeonju, South Korea.
C3 Chonnam National University; Chungnam National University; Seonam
   University; Wonkwang University; Wonkwang University; Jeonbuk National
   University; Jeonbuk National University; Jeonbuk National University;
   Jeonbuk National University Hospital
RP Kweon, SS (corresponding author), Chonnam Natl Univ, Sch Med, Dept Prevent Med, 5 Hak Dong, Kwangju 501746, South Korea.
EM ujingogo@paran.com
RI Kweon, Sun-Seog/AAZ-4732-2021; Jeong, Seul-Ki/KSL-7574-2024
OI Shin, Min-Ho/0000-0002-2217-5624; Jeong, Seul-Ki/0000-0002-9868-621X;
   KWEON, SUNSEOG/0000-0003-2378-8550; Nam, Hae-Sung/0000-0003-0911-4576
FU Research Institute of Medical Sciences, Chonnam National University
FX This study was supported by Research Institute of Medical Sciences,
   Chonnam National University.
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NR 47
TC 51
Z9 56
U1 0
U2 8
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1758-5996
J9 DIABETOL METAB SYNDR
JI Diabetol. Metab. Syndr.
PD FEB 6
PY 2014
VL 6
AR 14
DI 10.1186/1758-5996-6-14
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA AB9GX
UT WOS:000332100500001
PM 24502834
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Ortiz, L
   Nakamura, B
   Li, X
   Blumberg, B
   Luderer, U
AF Ortiz, Laura
   Nakamura, Brooke
   Li, Xia
   Blumberg, Bruce
   Luderer, Ulrike
TI In utero exposure to benzo[a]pyrene increases adiposity and
   causes hepatic steatosis in female mice, and glutathione deficiency is
   protective
SO TOXICOLOGY LETTERS
LA English
DT Article
DE Polycyclic aromatic hydrocarbons; Glutathione; Fatty liver; Glutamate
   cysteine ligase; Obesity; Prenatal programming
ID POLYCYCLIC AROMATIC-HYDROCARBONS; PARTICULATE AIR-POLLUTION; LONG-TERM
   EXPOSURE; LIGASE CATALYTIC SUBUNIT; METABOLIC-ACTIVATION;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; MATERNAL SMOKING; DOMOIC ACID;
   PPAR-GAMMA
AB Polycyclic aromatic hydrocarbons (PAHs), including benzo[a]pyrene (BaP), are ubiquitous environmental pollutants found in tobacco smoke, air pollution, and grilled foods. Reactive metabolites and reactive oxygen species generated during PAH metabolism are detoxified by reactions involving glutathione (GSH). Early life exposures to tobacco smoke and air pollution have been linked to increased risk of obesity and metabolic syndrome. We investigated the independent and interactive effects of prenatal exposure to BaP and GSH deficiency due to deletion of the modifier subunit of glutamate cysteine ligase (Gclm), the rate-limiting enzyme in GSH synthesis, on adiposity and hepatic steatosis in adult female F1 offspring. We mated Gclm(+/-) dams with Gclm(+/-) males and treated the pregnant dams with 0, 2, or 10 mg/kg/day BaP in sesame oil by oral gavage daily from gestational day 7 through 16. We analyzed metabolic endpoints in female Gclm(-/-) and Gclm(+/+) littermate F1 offspring. Prenatal BaP exposure significantly increased visceral adipose tissue weight, weight gain between 3 weeks and 7.5 months of age, hepatic lipid content measured by oil red 0 staining, and hepatic fatty acid beta-oxidation gene expression in Gclm(+/+), but not in Gclm(-/-), female offspring. Hepatic expression of lipid biosynthesis and antioxidant genes were decreased and increased, respectively, in Gclm(-/-) mice. Our results suggest that reported effects of pre-and pen-natal air pollution and tobacco smoke exposure on obesity may be mediated in part by PAHs. GSH deficiency is protective against the metabolic effects of prenatal BaP exposure. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
C1 [Ortiz, Laura; Nakamura, Brooke; Luderer, Ulrike] Univ Calif Irvine, Ctr Occupat & Environm Hlth, Dept Med, Irvine, CA 92617 USA.
   [Li, Xia; Blumberg, Bruce; Luderer, Ulrike] Univ Calif Irvine, Dept Dev & Cell Biol, Irvine, CA 92697 USA.
   [Luderer, Ulrike] Univ Calif Irvine, Program Publ Hlth, Irvine, CA 92697 USA.
C3 University of California System; University of California Irvine;
   University of California System; University of California Irvine;
   University of California System; University of California Irvine
RP Luderer, U (corresponding author), Ctr Occupat & Environm Hlth, 100 Theory Dr,Suite 100, Irvine, CA 92617 USA.
EM uluderer@uci.edu
OI Nakamura, Brooke/0000-0002-3381-9958
FU National Institutes of Health [R01 ES020454, R21 AG032087, RO1 ES015849,
   P30 CA062203]; UC Irvine Chao Family Comprehensive Cancer Center; UC
   Irvine School of Medicine Committee on Research Faculty Research Award;
   UC Irvine Office of Research; UC Irvine Center for Occupational and
   Environmental Health; National Cancer Institute [P30CA062203] Funding
   Source: NIH RePORTER; National Institute of Environmental Health
   Sciences [R01ES020454] Funding Source: NIH RePORTER
FX This work was supported by the National Institutes of Health (R01
   ES020454, and R21 AG032087 to U.L.; RO1 ES015849 to B.B; P30 CA062203,
   the UC Irvine Chao Family Comprehensive Cancer Center); by a UC Irvine
   School of Medicine Committee on Research Faculty Research Award; by the
   UC Irvine Office of Research; and by the UC Irvine Center for
   Occupational and Environmental Health.
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NR 73
TC 32
Z9 36
U1 3
U2 29
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0378-4274
EI 1879-3169
J9 TOXICOL LETT
JI Toxicol. Lett.
PD NOV 25
PY 2013
VL 223
IS 2
BP 260
EP 267
DI 10.1016/j.toxlet.2013.09.017
PG 8
WC Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Toxicology
GA 248GJ
UT WOS:000326684600019
PM 24107266
OA Green Published, Green Accepted
DA 2025-06-11
ER

PT J
AU Motohashi, S
   Mino, Y
   Hori, K
   Naito, T
   Hosokawa, S
   Furuse, H
   Ozono, S
   Mineta, H
   Kawakami, J
AF Motohashi, Shinya
   Mino, Yasuaki
   Hori, Katsuhito
   Naito, Takafumi
   Hosokawa, Seiji
   Furuse, Hiroshi
   Ozono, Seiichiro
   Mineta, Hiroyuki
   Kawakami, Junichi
TI Interindividual Variations in Aprepitant Plasma Pharmacokinetics in
   Cancer Patients Receiving Cisplatin-Based Chemotherapy for the First
   Time
SO BIOLOGICAL & PHARMACEUTICAL BULLETIN
LA English
DT Article
DE aprepitant; pharmacokinetics; total bilirubin; serum albumin; cytochrome
   P450 3A5
ID P RECEPTOR ANTAGONIST; PERFORMANCE LIQUID-CHROMATOGRAPHY;
   MASS-SPECTROMETRIC DETECTION; PLACEBO-CONTROLLED TRIAL; INDUCED NAUSEA;
   METABOLIC SYNDROME; GAMMA-GLUTAMYLTRANSFERASE; JAPANESE POPULATION;
   OXIDATIVE STRESS; LIVER-ENZYMES
AB The pharmacokinetics of aprepitant, a neurokinin-1 receptor antagonist, have not been fully evaluated in clinical settings. The aim of this study was to characterize the plasma pharmacokinetics of aprepitant and reveal their influence of laboratory tests and cytochrome P450 (CYP) 3A5 gene polymorphisms in cancer patients. Forty-four Japanese cancer patients receiving cisplatin-based chemotherapy for the first time following oral aprepitant (125 mg on day 1 and 80 mg on days 2 and 3) were enrolled. The patients did not have gastrointestinal disease and the clinical laboratory values were within their normal reference levels. The plasma concentrations of aprepitant 24 (day 2 predose), 72, and 120 h after the first aprepitant administration were determined using LC-MS/MS. The relationships between plasma exposure to aprepitant and body weight, clinical laboratory values, age, gender, or CYP3A5*3 were investigated. The median and interquartile ranges of the 120-h area under the plasma concentration time curve (AUC)(0-120) of aprepitant were 73215 and 55518-91121 ng h/mL. The coefficient of variation value for aprepitant AUC(0-120) was 53%. The AUC(0-120) of aprepitant was correlated with the levels of total bilirubin and serum albumin, respectively (r=0.454, p<0.01 and r=0.287, p=0.06), but not with other non-genetic factors and CYP3A5 genetic variants in a univariate analysis. The AUC(0-120) of aprepitant was significantly correlated with the level of total bilirubin (adjusted R-2=0.187, p<0.01) in a multivariate analysis. In conclusion, the plasma pharmacokinetics of aprepitant varied markedly in cancer patients receiving cisplatin-based chemotherapy for the first time and were correlated with the level of total bilirubin.
C1 [Motohashi, Shinya; Mino, Yasuaki; Hori, Katsuhito; Naito, Takafumi; Kawakami, Junichi] Hamamatsu Univ Sch Med, Dept Hosp Pharm, Higashi Ku, Hamamatsu, Shizuoka 4313192, Japan.
   [Hosokawa, Seiji; Mineta, Hiroyuki] Hamamatsu Univ Sch Med, Dept Otorhinolaryngol Head & Neck Surg, Higashi Ku, Hamamatsu, Shizuoka 4313192, Japan.
   [Furuse, Hiroshi; Ozono, Seiichiro] Hamamatsu Univ Sch Med, Dept Urol, Higashi Ku, Hamamatsu, Shizuoka 4313192, Japan.
C3 Hamamatsu University School of Medicine; Hamamatsu University School of
   Medicine; Hamamatsu University School of Medicine
RP Kawakami, J (corresponding author), Hamamatsu Univ Sch Med, Dept Hosp Pharm, Higashi Ku, 1-20-1 Handayama, Hamamatsu, Shizuoka 4313192, Japan.
EM kawakami-ham@umin.ac.jp
RI Mino, Yasuaki/GSN-6047-2022
OI Mino, Yasuaki/0000-0002-5706-1117
CR [Anonymous], 2001, Guidance for industry - bioanalytical method validation
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NR 27
TC 11
Z9 13
U1 0
U2 10
PU PHARMACEUTICAL SOC JAPAN
PI TOKYO
PA 2-12-15 SHIBUYA, SHIBUYA-KU, TOKYO, 150-0002, JAPAN
SN 0918-6158
J9 BIOL PHARM BULL
JI Biol. Pharm. Bull.
PD APR
PY 2013
VL 36
IS 4
BP 676
EP 681
PG 6
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 115SP
UT WOS:000316832500023
PM 23370406
DA 2025-06-11
ER

PT J
AU Chou, CL
   Pang, CY
   Lee, TJF
   Fang, TC
AF Chou, Chu-Lin
   Pang, Cheng-Yong
   Lee, Tony J. F.
   Fang, Te-Chao
TI Direct renin inhibitor prevents and ameliorates insulin resistance,
   aortic endothelial dysfunction and vascular remodeling in fructose-fed
   hypertensive rats
SO HYPERTENSION RESEARCH
LA English
DT Article
DE aliskiren; endothelial dysfunction; insulin resistance; vascular
   remodeling
ID HYPERINSULINEMIA-INDUCED HYPERTENSION; ANGIOTENSIN-II RECEPTOR;
   METABOLIC SYNDROME; OXIDATIVE STRESS; BLOOD-PRESSURE; CAUSAL ROLE;
   ALISKIREN; BLOCKADE; LOSARTAN; ACTIVATION
AB Angiotensin-converting enzyme inhibitors and angiotensin II type 1 receptor blockers can improve insulin resistance and vascular dysfunction in insulin-resistant rats; however, there are few reports on the effects of direct renin inhibitors on these conditions. We investigated the effects of a direct renin inhibitor, aliskiren, on insulin resistance, aortic endothelial dysfunction and vascular remodeling in fructose-fed hypertensive rats. Male Wistar-Kyoto rats were divided into four groups (n = 6 per group) and studied for 8 weeks: Group Con: standard chow diet; group Fru: high-fructose diet (60% fructose); Group FruA: high-fructose diet with concurrent aliskiren treatment (100 mg kg(-1) per day); and Group FruB: high-fructose diet with subsequent aliskiren treatment 4 weeks later. Blood was collected for biochemical assays, and isolated rings of the thoracic aorta were obtained for analysis of vascular reactivity, vascular structure and lipid peroxide. Rats fed with high-fructose diets developed significant systolic hypertension, decreased plasma nitrite (NO2; nitric oxide metabolite) levels and increased plasma glucose, insulin, triglyceride, total cholesterol and aortic lipid peroxide levels, and aortic wall thickness compared with control rats. Aliskiren treatment, either concurrent or subsequent, elevated plasma NO2 levels and reduced systolic hypertension, insulin resistance, dyslipidemia, aortic lipid peroxide levels and aortic wall hypertrophy in FHR. The peak endothelium-dependent aortic relaxations were significantly higher in rats that received aliskiren treatment than in those that did not. In conclusion, our findings suggest that aliskiren prevents and ameliorates insulin resistance, aortic endothelial dysfunction and oxidative vascular remodeling in fructose-fed hypertensive rats. Hypertension Research (2013) 36, 123-128; doi:10.1038/hr.2012.124; published online 16 August 2012
C1 [Chou, Chu-Lin; Pang, Cheng-Yong; Lee, Tony J. F.] Buddhist Tzu Chi Univ, Inst Med Sci, Hualien, Taiwan.
   [Chou, Chu-Lin; Fang, Te-Chao] Buddhist Tzu Chi Gen Hosp, Div Nephrol, Hualien 97004, Taiwan.
   [Lee, Tony J. F.] Buddhist Tzu Chi Univ, Inst Life Sci, Hualien, Taiwan.
   [Lee, Tony J. F.] Buddhist Tzu Chi Univ, Inst Pharmacol & Toxicol, Hualien, Taiwan.
   [Fang, Te-Chao] Tzu Chi Univ, Dept Med, Coll Med, Hualien, Taiwan.
C3 Tzu Chi University; Buddhist Tzu Chi General Hospital; Hualien Tzu Chi
   Hospital; Tzu Chi University; Tzu Chi University; Tzu Chi University
RP Fang, TC (corresponding author), Buddhist Tzu Chi Gen Hosp, Div Nephrol, 707,Sect 3,Chung Yang Rd, Hualien 97004, Taiwan.
EM fangtechao@yahoo.com.tw
RI Lee, Tony/JDM-3564-2023; Pang, Cheng-Yoong/R-4990-2019
OI Chou, Chu-Lin/0000-0002-9695-1067; Pang, Cheng-Yoong/0000-0002-9063-2858
FU Taiwan Society of Nephrology [TSN-2010-01]
FX This work was supported by a grant from Taiwan Society of Nephrology for
   providing 2010 Research Grants (TSN-2010-01) for this study. This study
   was presented at the 2012 Congress of the European Renal
   Association-European Dialysis and Transplant Association (Paris, France,
   May 24-27, 2012).
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NR 38
TC 35
Z9 36
U1 0
U2 12
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0916-9636
EI 1348-4214
J9 HYPERTENS RES
JI Hypertens. Res.
PD FEB
PY 2013
VL 36
IS 2
BP 123
EP 128
DI 10.1038/hr.2012.124
PG 6
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 114ZF
UT WOS:000316780800009
PM 22895064
OA Bronze
DA 2025-06-11
ER

PT J
AU Bláha, V
   Musil, F
   Smahelová, A
   Tichá, A
   Hyspler, R
   Haluzík, M
   Lesná, J
   Sobotka, L
AF Blaha, Vladimir
   Musil, Frantisek
   Smahelova, Alena
   Ticha, Alena
   Hyspler, Radomir
   Haluzik, Martin
   Lesna, Jana
   Sobotka, Lubos
TI Effects of body fat reduction on plasma adipocyte fatty acid-binding
   protein concentration in obese patients with type 1 diabetes mellitus
SO NEUROENDOCRINOLOGY LETTERS
LA English
DT Article
DE adipocyte fatty acid-binding protein; type 1 diabetes mellitus; obesity;
   insulin resistance; free fatty acids
ID METABOLIC SYNDROME; INSULIN-RESISTANCE; A-FABP; PITTSBURGH EPIDEMIOLOGY;
   ADIPOSE-TISSUE; WEIGHT-LOSS; COMPLICATIONS; BIOMARKER; ASSOCIATION;
   RESPONSES
AB OBJECTIVES: The influence of body fat reduction on adipocyte fatty acid-binding protein (A-FABP) in obese patients with type 1 diabetes mellitus (T1DM) was investigated to examine whether it relates to the etiopathogenesis of insulin resistance (IR) and obesity.
   METHODS: We studied 14 obese patients with T1DM and IR (42.6 +/- 9.4 years, BMI 32.4 +/- 2.1 kg/m(2)) and 13 non-obese control patients with T1DM (36.9 +/- 13.9 years, BMI 22.6 +/- 2.1 kg/m(2)). Plasma FABP was measured by ELISA and plasma free fatty acids (FFA) were measured spectrophotometrically before weight reduction, immediately after 7 days of fasting and after 21 days on a low-calorie diet. The control group was studied only after overnight fasting. Body composition was examined using bioimpedance spectroscopy. The means +/- SD, T-test, one-way ANOVA and Spearman's correlation were used for statistical evaluation.
   RESULTS: All patients tolerated the period of fasting. Obese T1DM patients lost 6.1 +/- 1.1 kg. There was a significant decrease in body mass index and body fat measured 21 days after weight reduction (p<0.05). Plasma FABP and FFA concentrations in obese T1DM patients before weight reduction were significantly higher than in controls, further increased significantly after fasting (p<0.05) and were restored thereafter. Significant positive correlations between FABP and FFA and between FABP and BMI (p<0.05) were found.
   CONCLUSION: Increased plasma FABP indicates insulin resistance in obese patients with T1DM. Weight reduction in T1DM patients is associated with a desirable decrease of body fat and transiently increased FABP. This increase might be a temporary adaptation of metabolism to non-stress fasting.
C1 [Blaha, Vladimir; Musil, Frantisek; Smahelova, Alena; Ticha, Alena; Hyspler, Radomir; Lesna, Jana; Sobotka, Lubos] Univ Hosp Hradec Kralove, Dept Med Metab Care & Gerontol 3, Hradec Kralove 50005, Czech Republic.
   [Blaha, Vladimir; Musil, Frantisek; Smahelova, Alena; Ticha, Alena; Hyspler, Radomir; Lesna, Jana; Sobotka, Lubos] Charles Univ Prague, Fac Med, Hradec Kralove 50005, Czech Republic.
   [Lesna, Jana] Univ Hosp Hradec Kralove, Dept Clin Biochem, Hradec Kralove 50005, Czech Republic.
   [Haluzik, Martin] Charles Univ Prague, Fac Med 1, Dept Med 3, Prague, Czech Republic.
   [Haluzik, Martin] Gen Univ Hosp, Prague, Czech Republic.
C3 University Hospital Hradec Kralove; Charles University Prague;
   University Hospital Hradec Kralove; University Hospital Hradec Kralove;
   Charles University Prague; General University Hospital Prague
RP Bláha, V (corresponding author), Univ Hosp Hradec Kralove, Dept Med Metab Care & Gerontol 3, Sokolska 581, Hradec Kralove 50005, Czech Republic.
EM blaha@lfhk.cuni.cz
RI Musil, Frantisek/IAO-5811-2023; Sobotka, Lubos/V-2620-2017; Ticha,
   Alena/P-9782-2017; Blaha, Vladimir/C-1151-2016; Haluzik,
   Martin/I-8190-2017
OI Musil, Frantisek/0000-0002-9885-2580; Sobotka,
   Lubos/0000-0002-0372-5790; Ticha, Alena/0000-0003-1329-1268; Blaha,
   Vladimir/0000-0001-8088-9919; Haluzik, Martin/0000-0002-0201-6888
FU Ministry of Health of the Czech Republic [NT/12287-5]; Medical Faculty
   Charles University in Hradec Kralove, Czech Republic [PRVOUK P37/12]
FX This work was supported by research project IGA No. NT/12287-5 from the
   Ministry of Health of the Czech Republic and PRVOUK P37/12 from the
   Medical Faculty Charles University in Hradec Kralove, Czech Republic.
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NR 32
TC 5
Z9 5
U1 0
U2 3
PU MAGHIRA & MAAS PUBLICATIONS
PI MUNSBACH
PA MAGHIRA & MAAS S A R L, 6C, RUE GABRIEL LIPPMANN, L-5365 MUNSBACH,
   LUXEMBOURG
SN 0172-780X
J9 NEUROENDOCRINOL LETT
JI Neuroendocrinol. Lett.
PY 2012
VL 33
SU 2
BP 6
EP 12
PG 7
WC Endocrinology & Metabolism; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology
GA 052CN
UT WOS:000312175400003
PM 23183502
DA 2025-06-11
ER

PT J
AU Kowdley, KV
   Belt, P
   Wilson, LA
   Yeh, MM
   Neuschwander-Tetri, BA
   Chalasani, N
   Sanyal, AJ
   Nelson, JE
AF Kowdley, Kris V.
   Belt, Patricia
   Wilson, Laura A.
   Yeh, Matthew M.
   Neuschwander-Tetri, Brent A.
   Chalasani, Naga
   Sanyal, Arun J.
   Nelson, James E.
CA NASH Clinical Res Network
TI Serum ferritin is an independent predictor of histologic severity and
   advanced fibrosis in patients with nonalcoholic fatty liver disease
SO HEPATOLOGY
LA English
DT Article
ID TUMOR-NECROSIS-FACTOR; CHRONIC HEPATITIS-C; NF-KAPPA-B; IRON-OVERLOAD;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; HEAVY-CHAIN; RELATIVE
   CONTRIBUTION; MAJOR DETERMINANTS; METABOLIC SYNDROME
AB Serum ferritin (SF) levels are commonly elevated in patients with nonalcoholic fatty liver disease (NAFLD) because of systemic inflammation, increased iron stores, or both. The aim of this study was to examine the relationship between elevated SF and NAFLD severity. Demographic, clinical, histologic, laboratory, and anthropometric data were analyzed in 628 adult patients with NAFLD (age, =18 years) with biopsy-proven NAFLD and an SF measurement within 6 months of their liver biopsy. A threshold SF >1.5 x upper limit of normal (ULN) (i.e., >300 ng/mL in women and >450 ng/mL in men) was significantly associated with male sex, elevated serum alanine aminotransferase, aspartate aminotransferase, iron, transferrin-iron saturation, iron stain grade, and decreased platelets (P < 0.01). Histologic features of NAFLD were more severe among patients with SF >1.5 x ULN, including steatosis, fibrosis, hepatocellular ballooning, and diagnosis of NASH (P < 0.026). On multiple regression analysis, SF >1.5 x ULN was independently associated with advanced hepatic fibrosis (odds ratio [OR], 1.66; 95% confidence interval [CI], 1.05-2.62; P = 0.028) and increased NAFLD Activity Score (NAS) (OR, 1.99; 95% CI, 1.06-3.75; P = 0.033). Conclusions: A SF >1.5 x ULN is associated with hepatic iron deposition, a diagnosis of NASH, and worsened histologic activity and is an independent predictor of advanced hepatic fibrosis among patients with NAFLD. Furthermore, elevated SF is independently associated with higher NAS, even among patients without hepatic iron deposition. We conclude that SF is useful to identify NAFLD patients at risk for NASH and advanced fibrosis. (HEPATOLOGY 2012;55:77-85)
C1 [Kowdley, Kris V.; Nelson, James E.] Virginia Mason Med Ctr, Benaroya Res Inst, Seattle, WA 98101 USA.
   [Belt, Patricia; Wilson, Laura A.] Johns Hopkins Univ, Sch Publ Hlth, Baltimore, MD USA.
   [Yeh, Matthew M.] Univ Washington, Med Ctr, Seattle, WA 98195 USA.
   [Neuschwander-Tetri, Brent A.] St Louis Univ, St Louis, MO 63103 USA.
   [Chalasani, Naga] Indiana Univ, Indianapolis, IN 46204 USA.
   [Sanyal, Arun J.] Virginia Commonwealth Univ, Richmond, VA USA.
   [Kowdley, Kris V.] Virginia Mason Med Ctr, Inst Digest Dis, Ctr Liver Dis, Seattle, WA 98101 USA.
C3 Benaroya Research Institute; Virginia Mason Medical Center; Johns
   Hopkins University; University of Washington; University of Washington
   Seattle; Saint Louis University; Indiana University System; Indiana
   University Indianapolis; Virginia Commonwealth University; Virginia
   Mason Medical Center
RP Kowdley, KV (corresponding author), Virginia Mason Med Ctr, Benaroya Res Inst, Seattle, WA 98101 USA.
EM kkowdley@benaroyaresearch.org
RI Neuschwander-Tetri, Brent/IST-8116-2023; Kowdley, Kris/AAF-5202-2019
FU National Cancer Institute; National Institute of Diabetes and Digestive
   and Kidney Diseases [U01DK061718, U01DK061728, U01DK061731, U01DK061732,
   U01DK061734, U01DK061737, U01DK061738, U01DK061730, U01DK061713];
   National Institute of Child Health and Human Development; National
   Institutes of Health [K24DK002957, R56DK087696]; General Clinical
   Research Centers or Clinical and Translational Science [UL1RR024989,
   M01RR000750, M01RR00188, UL1RR02413101, M01RR000827, UL1RR02501401,
   M01RR000065, M01RR020359]
FX This work was supported, in part, by the Intramural Research Program of
   the National Cancer Institute. The Nonalcoholic Steatohepatitis Clinical
   Research Network (NASH CRN) is supported by the National Institute of
   Diabetes and Digestive and Kidney Diseases (grants U01DK061718,
   U01DK061728, U01DK061731, U01DK061732, U01DK061734, U01DK061737,
   U01DK061738, U01DK061730, and U01DK061713) and the National Institute of
   Child Health and Human Development. K.V.K. is also supported by National
   Institutes of Health grants K24DK002957 and R56DK087696. Several
   clinical centers use support from General Clinical Research Centers or
   Clinical and Translational Science Awards in conduct of NASH CRN Studies
   (grants UL1RR024989, M01RR000750, M01RR00188, UL1RR02413101,
   M01RR000827, UL1RR02501401, M01RR000065, and M01RR020359).
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NR 63
TC 400
Z9 425
U1 0
U2 51
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0270-9139
EI 1527-3350
J9 HEPATOLOGY
JI Hepatology
PD JAN
PY 2012
VL 55
IS 1
BP 77
EP 85
DI 10.1002/hep.24706
PG 9
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 867WS
UT WOS:000298486100011
PM 21953442
OA Bronze, Green Accepted
DA 2025-06-11
ER

PT J
AU Roh, WG
   Shin, HC
   Choi, JH
   Lee, YJ
   Kim, K
AF Roh, Won-Gyun
   Shin, Ho-Chol
   Choi, Ji-Ho
   Lee, Yeon Ji
   Kim, Kyoungwoo
TI Alcohol consumption and higher incidence of impaired fasting glucose or
   type 2 diabetes in obese Korean men
SO ALCOHOL
LA English
DT Article
DE Alcohols; Diabetes mellitus; Obesity; Risk factors; Male; Korea; Blood
   glucose
ID GAMMA-GLUTAMYL-TRANSFERASE; MIDDLE-AGED JAPANESE; FOOD FREQUENCY
   QUESTIONNAIRE; INSULIN-RESISTANCE; METABOLIC SYNDROME; OXIDATIVE STRESS;
   PLASMA-GLUCOSE; RISK-FACTORS; FOLLOW-UP; ETHANOL
AB It is inconclusive whether moderate alcohol consumption reduces the diabetes risk. We observed the development of impaired fasting glucose or type 2 diabetes according to the amount of alcohol intake and body mass index. The annual health evaluation data of 2,500 male workers from 2002 to 2006 were reviewed retrospectively deleting personal identification code. The information contained sex, age, medical history, smoking status, alcohol consumption, participating regular exercise, anthropometric, and biochemistry measurement. Impaired fasting glucose or diabetes was determined when fasting plasma glucose was >= 100 mg/dL. Thousand seven hundred seven subjects were eligible after excluding medical history of diabetes or fasting glucose >= 100 mg/dL at baseline. The relative risks of its development in group of taking 1-14, 15-29, and >= 30.0 g ethanol were 0.842 (95% confidence interval [CI], 0.603-1.176), 1.068 (95% CI, 0.736-1.551), and 1.019 (95% CI, 0.662-1.568) within normal weight group, 1.164 (95% CI, 0.795-1.705), 1.421 (95% CI, 0.947-2.133), and 1.604 (95% CI, 1.031-2.495) within overweight group, and 1.498 (95% CI, 1.042-2.153), 1.634 (95% CI, 1.091-2.4217), and 1.563 (95% CI, 1.019-2.396) within obese group each after adjusting age, family history of diabetes, smoking, exercise, serum fasting glucose, aspartate aminotransferase, and gamma-glutamyltransferase with nondrinkers as a reference group. Not only high alcohol consumption but also moderate drinking was related with higher incidence of impaired fasting glucose or diabetes in obese Korean men. (C) 2009 Elsevier Inc. All rights reserved.
C1 [Kim, Kyoungwoo] Inje Univ Seoul Paik Hosp, Dept Family Med, Seoul 100032, South Korea.
   [Roh, Won-Gyun; Shin, Ho-Chol; Choi, Ji-Ho; Lee, Yeon Ji] Inha Univ, Coll Med, Dept Family Med, Inchon, South Korea.
C3 Inje University; Inha University
RP Kim, K (corresponding author), Inje Univ Seoul Paik Hosp, Dept Family Med, 85 Jeo Dong, Seoul 100032, South Korea.
EM kwkimfm@gmail.com
RI Kim, Il Young/LLK-4732-2024
OI Kim, Kyoungwoo/0000-0001-7294-1262
FU INHA UNIVERSITY
FX This work was supported by INHA UNIVERSITY Research Grant.
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NR 49
TC 25
Z9 30
U1 0
U2 3
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0741-8329
EI 1873-6823
J9 ALCOHOL
JI Alcohol
PD DEC
PY 2009
VL 43
IS 8
BP 643
EP 648
DI 10.1016/j.alcohol.2009.10.005
PG 6
WC Substance Abuse; Pharmacology & Pharmacy; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Substance Abuse; Pharmacology & Pharmacy; Toxicology
GA 626LS
UT WOS:000279968100009
PM 20004342
DA 2025-06-11
ER

PT J
AU Demircan, S
   Yazici, M
   Durna, K
   Kilicaslan, F
   Demir, S
   Pinar, M
   Gulel, O
AF Demircan, Sabri
   Yazici, Mustafa
   Durna, Kenan
   Kilicaslan, Fethi
   Demir, Serdar
   Pinar, Mesut
   Gulel, Okan
TI The Importance of Gamma-Glutamyltransferase Activity in Patients with
   Coronary Artery Disease
SO CLINICAL CARDIOLOGY
LA English
DT Article
ID C-REACTIVE PROTEIN; MIDDLE-AGED MEN; CARDIOVASCULAR-DISEASE; OXIDATIVE
   STRESS; HEART-DISEASE; METABOLIC SYNDROME; MYOCARDIAL-INFARCTION;
   RISK-FACTOR; INFLAMMATION; MORTALITY
AB Background: In this study, we sought to investigate the relation of gamma-glutamyltransferase (GGT) levels with the significance of coronary artery disease (CAD), clinical presentation, left ventricular (LV) function, and inflammatory activity.
   Methods: A total of 235 patients (mean age: 60.1 +/- 10.5 years, 166[70%] males) who had coronary angiography were included in the study. Patients who had CAD constituted the study group (Group 1, n = 189) and patients who had insignificant coronary disease or normal coronary activity constituted the control group (Group 2, n = 46).
   Results: GGT levels were higher in Group 1 than Group 2 (38.7 +/- 30.9 U/L versus 27.5 +/- 17.5 U/L, p = 0.025). Left ventricular ejection fraction (LVEF) was lower in Group 1 than Group 2 (52.6% +/- 11.7% versus 58.8% +/- 11.3%, P<0.002). GGT activity (40.2 +/- 32.5 U/L versus 29.1 +/- 18.3 U/L, P<0.002) and c-reactive protein (CRP) levels (33.9 +/- 43.6 mg/dl versus 17.8 +/- 29.8 mg/dl, P<0.002) were higher, LVEF (52.6% +/- 12.1% versus 56.5% +/- 11.0%, P = 0.021) was lower in patients with acute coronary syndrome compared with stable CAD group. In regression analysis, CRIP levels (p<0.0001, odds ratio [OR]= 3.77, 95% confidence interval [CI] 0.10<OR<0.32), LVEF (p = 0.016, OR = -2.44, 95% Cl - 0.95<OR<-0.10) and LV end-diastolic pressure (P = 0.015, OR = 4.31, 95% Cl - 1.19<OR -0.13) were independent predictors of GGT activity.
   Conclusions: The increased GGT activity is related to LV function, clinical stability, and inflammatory activity rather than the severity of CAD, Measurement of GGT activity may be useful in predicting cardiovascular risk.
C1 [Demircan, Sabri; Yazici, Mustafa; Durna, Kenan; Demir, Serdar; Pinar, Mesut; Gulel, Okan] Ondokuz Mayis Univ, Fac Med, Dept Cardiol, TR-55139 Kurupelit, Samsun, Turkey.
   [Kilicaslan, Fethi] GATA Haydarpasa Mil Training Hosp, Istanbul, Turkey.
C3 Ondokuz Mayis University; Istanbul Haydarpasa Sultan Abdulhamid Training
   & Research Hospital; Gulhane Military Medical Academy
RP Demircan, S (corresponding author), Ondokuz Mayis Univ, Fac Med, Dept Cardiol, TR-55139 Kurupelit, Samsun, Turkey.
EM sabridemircan@yahoo.com
RI Gulel, Okan/JCO-1582-2023; Demircan, Sabri/MSZ-6783-2025; demir,
   serdar/AGC-4789-2022
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NR 34
TC 27
Z9 29
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0160-9289
EI 1932-8737
J9 CLIN CARDIOL
JI Clin. Cardiol.
PD APR
PY 2009
VL 32
IS 4
BP 220
EP 225
DI 10.1002/clc.20345
PG 6
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 433HS
UT WOS:000265195500011
PM 19353699
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Chrysohoou, C
   Panagiotakos, DB
   Pitsavos, C
   Skoumas, I
   Papademetriou, L
   Economou, M
   Stefanadis, C
AF Chrysohoou, Christina
   Panagiotakos, Demosthenes B.
   Pitsavos, Christos
   Skoumas, Ioannis
   Papademetriou, Lambros
   Economou, Manolis
   Stefanadis, Christodoulos
TI The implication of obesity on total antioxidant capacity in apparently
   healthy men and women: The ATTICA study
SO NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
LA English
DT Article
DE obesity; antioxidant
ID INDEPENDENT RISK-FACTOR; C-REACTIVE PROTEIN; CARDIOVASCULAR-DISEASE;
   MEDITERRANEAN DIET; METABOLIC SYNDROME; OXIDATIVE STRESS; ASSOCIATION
AB Background and aim: We evaluated the association of obesity with serum total antioxidant capacity (TAC), in a population-based sample of 3042 adults.
   Methods and results: During 2001-2002 we randomly enrolled 1514 men (18-87 years old) and 1528 women (18-89 years old), from the Attica area in Greece into the study, and the sample was stratified by the age-sex distribution of the region (census 2001). Among several variables we also measured serum TAC and weight, height, waist and hip circumferences. Waist circumference greater than 102 cm for men and 88 cm for women was considered an indicator of central fat.
   Methods and results: Mean waist circumference was 98 +/- 13 cm in men and 84 +/- 22 cm in women (P < 0.001), while mean hip circumference was 106 +/- 28 cm in men and 103 +/- 13 cm in women (P < 0.001). Central fat prevailed in 53% of men and 45% of women (P < 0.001). Mate participants with central fat exhibited 5% lower TAC concentrations compared to leaner individuals (214 +/- 35 vs. 226 +/- 33 mu mol/L, P = 0.04) and female participants with central fat exhibited 7% lower TAC concentrations (256 +/- 38 vs. 239 +/- 27 mu mol/L, P = 0.03). Similarly, obese or overweight mate participants had 6% lower TAC concentrations compared to normal weight (217 +/- 33 vs. 234 +/- 39 mu mol/L, P = 0.03) and female obese or overweight participants had 10% tower TAC concentrations (226 +/- 32 vs. 250 +/- 30 mu mol/L, P = 0.02) compared to the others.
   Conclusions: Our results suggest an inverse relationship between body fat, central adiposity and antioxidant capacity, irrespective of age and various other potential confounders, namely smoking, physical activity, dietary habits, blood pressure, glucose levels, and lipid concentrations. (C) 2006 Elsevier B.V. All rights reserved.
C1 Univ Athens, Sch Med, Cardiol Clin 1, GR-11527 Athens, Greece.
   Harokopio Univ, Dept Nutr & Dietet, Athens, Greece.
C3 National & Kapodistrian University of Athens; Athens Medical School;
   Harokopio University Athens
RP Panagiotakos, DB (corresponding author), 46 Paleon Polemiston St, Attica 16674, Greece.
EM d.b.panagiotakos@usa.net
RI Panagiotakos, Demosthenes/K-8294-2019; Stefanadis,
   Christodoulos/ABH-2232-2020; papadimitriou, lampros/I-3316-2013
OI Stefanadis, Christodoulos/0000-0001-5974-6454; papadimitriou,
   lampros/0000-0003-3356-0963; Chrysohoou, Christina/0000-0002-6340-3996
CR [Anonymous], 1997, WHO TECHN REP SER
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NR 24
TC 140
Z9 149
U1 0
U2 7
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0939-4753
EI 1590-3729
J9 NUTR METAB CARDIOVAS
JI Nutr. Metab. Carbiovasc. Dis.
PD OCT
PY 2007
VL 17
IS 8
BP 590
EP 597
DI 10.1016/j.numecd.2006.05.007
PG 8
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism; Nutrition
   & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism;
   Nutrition & Dietetics
GA 220YE
UT WOS:000250192400005
PM 16901682
DA 2025-06-11
ER

PT J
AU Hanson, AJ
   Banks, WA
   Bettcher, LF
   Pepin, R
   Raftery, D
   Navarro, SL
   Craft, S
AF Hanson, Angela J.
   Banks, William A.
   Bettcher, Lisa F.
   Pepin, Robert
   Raftery, Daniel
   Navarro, Sandi L.
   Craft, Suzanne
TI Cerebrospinal Fluid Metabolomics: Pilot Study of Using Metabolomics to
   Assess Diet and Metabolic Interventions in Alzheimer's Disease and Mild
   Cognitive Impairment
SO METABOLITES
LA English
DT Article
DE metabolomics; ketone bodies; cerebrospinal fluid; Alzheimer's; blood
   brain barrier
ID BETA-HYDROXYBUTYRATE; INSULIN-RESISTANCE; ENERGY-METABOLISM; OXIDATIVE
   STRESS; APOLIPOPROTEIN-E; HIGH-FAT; BRAIN; PLASMA; MODEL; BREAKFAST
AB Brain glucose hypometabolism is an early sign of Alzheimer's disease (AD), and interventions which offset this deficit, such as ketogenic diets, show promise as AD therapeutics. Conversely, high-fat feeding may exacerbate AD risk. We analyzed the metabolomic profile of cerebrospinal fluid (CSF) in a pilot study of older adults who underwent saline and triglyceride (TG) infusions. Older adults (12 cognitively normal (CN), age 65.3 +/- 8.1, and 9 with cognitive impairment (CI), age 70.9 +/- 8.6) underwent a 5 h TG or saline infusion on different days using a random crossover design; CSF was collected at the end of infusion. Aqueous metabolites were measured using a targeted mass spectroscopy (MS) platform focusing on 215 metabolites from over 35 different metabolic pathways. Data were analyzed using MetaboAnalyst 4.0 and SAS. Of the 215 targeted metabolites, 99 were detectable in CSF. Only one metabolite significantly differed by treatment: the ketone body 3-hydroxybutyrate (HBA). Post hoc analyses showed that HBA levels were associated with age and markers of metabolic syndrome and demonstrated different correlation patterns for the two treatments. When analyzed by cognitive diagnosis group, TG-induced increases in HBA were over 3 times higher for those with cognitive impairment (change score CN +9.8 uM +/- 8.3, CI +32.4 +/- 7.4, p = 0.0191). Interestingly, individuals with cognitive impairment had higher HBA levels after TG infusion than those with normal cognition. These results suggest that interventions that increase plasma ketones may lead to higher brain ketones in groups at risk for AD and should be confirmed in larger intervention studies.
C1 [Hanson, Angela J.; Banks, William A.] Univ Washington, Dept Med, Div Gerontol & Geriatr Med, Seattle, WA 98104 USA.
   [Banks, William A.] Vet Affairs Puget Sound Hlth Care Syst, Geriatr Res Educ & Clin Ctr, Seattle, WA 98102 USA.
   [Bettcher, Lisa F.; Pepin, Robert; Raftery, Daniel] Univ Washington, Northwest Metabol Res Ctr, Dept Anesthesiol & Pain Med, Seattle, WA 98109 USA.
   [Navarro, Sandi L.] Fred Hutchinson Canc Ctr, Div Publ Hlth Sci, Seattle, WA 98109 USA.
   [Craft, Suzanne] Wake Forest Sch Med, Dept Internal Med, Winston Salem, NC 27109 USA.
C3 University of Washington; University of Washington Seattle; US
   Department of Veterans Affairs; Veterans Health Administration (VHA);
   Vet Affairs Puget Sound Health Care System; Geriatric Research Education
   & Clinical Center; University of Washington; University of Washington
   Seattle; Fred Hutchinson Cancer Center; Wake Forest University
RP Hanson, AJ (corresponding author), Univ Washington, Dept Med, Div Gerontol & Geriatr Med, Seattle, WA 98104 USA.
EM hansonaj@uw.edu
RI Banks, William/K-1330-2017; L. Navarro, Sandi/V-8943-2019
OI Navarro, Sandi/0000-0002-4260-2486; Hanson, Angela/0000-0002-5985-2916;
   Raftery, Daniel/0000-0003-2467-8118
FU National Institutes of Health [K23AG047978, P30DK035816, S10OD021562];
   Veterans Affairs Medical Center; Chair of Medicine Scholars Award from
   the University of Washington School of Medicine.
FX This study was funded by K23AG047978, P30DK035816, and S10OD021562 from
   the National Institutes of Health, the Veterans Affairs Medical Center,
   and the Chair of Medicine Scholars Award from the University of
   Washington School of Medicine.
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NR 43
TC 0
Z9 0
U1 1
U2 5
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2218-1989
J9 METABOLITES
JI Metabolites
PD APR
PY 2023
VL 13
IS 4
AR 569
DI 10.3390/metabo13040569
PG 13
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA E9UW0
UT WOS:000978915200001
PM 37110227
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Tan, LJ
   Hwang, SB
   Jun, S
   Joung, H
   Shin, S
AF Tan, Li-Juan
   Hwang, Su Bin
   Jun, Shinyoung
   Joung, Hyojee
   Shin, Sangah
TI Dietary antioxidant consumption and the risk of type 2 diabetes in South
   Korean adults: a prospective cohort study based on the Health Examinees
   study
SO BMJ OPEN
LA English
DT Article
DE diabetes & endocrinology; epidemiology; nutrition & dietetics; public
   health; statistics & research methods
ID FLAVONOID INTAKE; METABOLIC SYNDROME; ASSOCIATION; MELLITUS; WOMEN;
   INFLAMMATION; PREVALENCE; ACTIVATION; CAPACITY; STRESS
AB Objectives Antioxidants are common dietary compounds with multiple health benefits. This study aimed to identify the association between dietary antioxidant consumption and the incidence of type 2 diabetes (T2D) mellitus (defined using the Korean Diabetes Association criteria) in South Korean adults. Design Baseline and follow-up data from the Health Examinees (HEXA) study, a large-scale community-based genomic cohort study conducted in South Korea Setting A South Korean community. Participants A total of 20 594 participants, aged 40-79 years, who participated in the baseline and follow-up surveys of the HEXA study were included. After an average of 5 years of follow-up, there were 332 men and 360 women with T2D. Results Participants with the highest total flavonoid consumption (Q5) had a lower risk of T2D (men: HR 0.63; 95% CI 0.42 to 0.93; p value for trend=0.0169; and women: HR 0.54; 95% CI 0.438 to 0.78; p value for trend=0.0001) than those with the lowest consumption (Q1). Dietary total antioxidant capacity was significantly inversely associated with the development of T2D mellitus in women participants alone (HR 0.58; 95% CI 0.40 to 0.83; p value for trend=0.0004). Stratified analyses according to age and body mass index (BMI) showed that dietary total flavonoid consumption and total antioxidant capacity had a negative association with the development of T2D in women aged >52 years and women with BMI >25 kg/m(2). Conclusions Dietary flavonoid consumption and total antioxidant capacity were associated with a lower risk of T2D in South Korean adults, especially in women aged >52 years and overweight. The findings of this study may provide reference data for the modification of dietary guidelines for South Koreans.
C1 [Tan, Li-Juan; Hwang, Su Bin; Shin, Sangah] Chung Ang Univ, Dept Food & Nutr, Seoul, South Korea.
   [Jun, Shinyoung] Natl Canc Ctr, Dept Canc Biomed Sci, Grad Sch Canc Sci & Policy, Goyang, South Korea.
   [Joung, Hyojee] Seoul Natl Univ, Grad Sch Publ Hlth, Dept Publ Hlth, Seoul, South Korea.
C3 Chung Ang University; National Cancer Center - Korea (NCC); Seoul
   National University (SNU)
RP Shin, S (corresponding author), Chung Ang Univ, Dept Food & Nutr, Seoul, South Korea.
EM ivory8320@cau.ac.kr
RI Jun, Shinyoung/MUO-2043-2025; Tan, LiJuan/LUW-7908-2024; Joung,
   Hyojee/AAU-9502-2020
OI TAN, LIJUAN/0000-0002-8970-0884
FU National Research Foundation of Korea (NRF) - Korea Government (Ministry
   of Science and ICT, MSIT) [2022R1F1A1074279]; Chung--Ang University
   Young Scientist Scholarship (CAYSS)
FX This research was supported by the National Research Foundation of Korea
   (NRF) grant funded by the Korea Government (Ministry of Science and ICT,
   MSIT) (No 2022R1F1A1074279). This research was supported by the
   Chung--Ang University Young Scientist Scholarship (CAYSS) in 2021.
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NR 51
TC 4
Z9 4
U1 0
U2 2
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2044-6055
J9 BMJ OPEN
JI BMJ Open
PD JUL
PY 2022
VL 12
IS 7
AR e065073
DI 10.1136/bmjopen-2022-065073
PG 10
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 2W4LF
UT WOS:000824496500011
PM 35820762
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Zhang, R
   Zhang, H
   Wang, Y
   Tang, LJ
   Li, G
   Huang, OY
   Chen, SD
   Targher, G
   Byrne, CD
   Gu, BB
   Zheng, MH
AF Zhang, Rui
   Zhang, Huai
   Wang, Yi
   Tang, Liang-Jie
   Li, Gang
   Huang, Ou-Yang
   Chen, Sui-Dan
   Targher, Giovanni
   Byrne, Christopher D.
   Gu, Bin-Bin
   Zheng, Ming-Hua
TI Higher consumption of animal organ meat is associated with a lower
   prevalence of nonalcoholic steatohepatitis
SO HEPATOBILIARY SURGERY AND NUTRITION
LA English
DT Article
DE Nonalcoholic fatty liver disease (NAFLD); nonalcoholic steatohepatitis
   (NASH); diet; organ meat; red meat; metabolic dysfunction-associated
   fatty liver disease (MAFLD)
ID FATTY LIVER-DISEASE; OXIDATIVE STRESS; METABOLIC SYNDROME;
   PHYSICAL-ACTIVITY; OBESITY; ATHEROSCLEROSIS; INFLAMMATION; VALIDATION;
   MORTALITY; DIET
AB Background: Animal organ meat (offal) is a food with high nutrient density that is popular in different parts of the world, but its relationship with nonalcoholic steatohepatitis (NASH) is unclear. We aimed to examine whether daily animal organ meat consumption is associated with the presence of NASH in individuals with nonalcoholic fatty liver disease (NAFLD).
   Methods: A total of 136 Chinese adults with biopsy-proven NAFLD were included. Definite NASH was defined as NAFTA) activity score >= 4 and at least one point for steatosis, ballooning, and lobular inflammation. Daily animal organ meat consumption was estimated using a self-administered validated food frequency questionnaire. Logistic regression analysis was performed to assess the association between animal organ meat intake and liver disease severity.
   Results: The 136 participants (80.9% men) of the study had a mean +/- standard deviation (SD) age of 39.0 +/- 12.5 years and body mass index of 27.4 +/- 3.6 kg/m(2). Prevalence of definite NASH was 65.4%. Daily median organ meat consumption was 1.30 g/1,000 kcal. Animal organ meat consumption was inversely associated with the presence of NASH even after adjustment of demographics, lifestyle variables, metabolic and dietary factors, as well as liver fibrosis stage; adjusted-odds ratios (95% confidence intervals) for NASH were 0.15 (0.03, 0.69) for the highest tertile and 0.18 (0.05, 0.70) for the medium tertile, compared to the lowest (reference) tertile of animal organ meat intake (P value for trend =0.024).
   Conclusions: Our results suggest for the first time that higher animal organ meat consumption is associated with a lower prevalence of NASH in Chinese individuals with biopsy-proven NAFLD.
C1 [Zhang, Rui; Wang, Yi; Gu, Bin-Bin] Wenzhou Med Univ, Affiliated Hosp 1, Dept Nutr, Wenzhou, Peoples R China.
   [Zhang, Huai] Wenzhou Med Univ, Affiliated Hosp 1, Biostat & Med Qual Management Off, Wenzhou, Peoples R China.
   [Tang, Liang-Jie; Li, Gang; Huang, Ou-Yang; Zheng, Ming-Hua] Wenzhou Med Univ, Affiliated Hosp 1, Dept Hepatol, MAFLD Res Ctr, 2 Fuxue Lane, Wenzhou 325000, Peoples R China.
   [Chen, Sui-Dan] Wenzhou Med Univ, Affiliated Hosp 1, Dept Pathol, Wenzhou, Peoples R China.
   [Targher, Giovanni] Univ Verona, Dept Med, Sect Endocrinol Diabet & Metab, Verona, Italy.
   [Targher, Giovanni] Azienda Osped Univ Integrata Verona, Verona, Italy.
   [Byrne, Christopher D.] Southampton Gen Hosp, Univ Hosp Southampton, Biomed Res Ctr, Southampton Natl Inst Hlth Res, Southampton, Hants, England.
   [Zheng, Ming-Hua] Wenzhou Med Univ, Inst Hepatol, Wenzhou, Peoples R China.
   [Zheng, Ming-Hua] Key Lab Diag & Treatment Dev Chron Liver Dis Zhej, Wenzhou, Peoples R China.
C3 Wenzhou Medical University; Wenzhou Medical University; Wenzhou Medical
   University; Wenzhou Medical University; University of Verona; University
   of Verona; Azienda Ospedaliera Universitaria Integrata Verona;
   University of Southampton; Wenzhou Medical University
RP Zheng, MH (corresponding author), Wenzhou Med Univ, Affiliated Hosp 1, Dept Hepatol, MAFLD Res Ctr, 2 Fuxue Lane, Wenzhou 325000, Peoples R China.
EM zhengmh@wmu.edu.cn
RI gu, binbin/KFQ-9951-2024; Zhang, Huai/AFX-2519-2022; Zheng,
   Ming-Hua/H-5584-2019; Targher, Giovanni/AAB-9008-2019
FU National Natural Science Foundation of China [82070588]; High Level
   Creative Talents from Department of Public Health in Zhejiang Province
   [S2032102600032]; Project of New Century 551 Talent Nurturing in
   Wenzhou, Wenzhou Science and Technology Bureau [Y20190530]; University
   School of Medicine of Verona in Italy; Southampton NIHR Biomedical
   Research Centre in UK [IS-BRC-20004]
FX This work was supported by grants from the National Natural Science
   Foundation of China (No. 82070588), High Level Creative Talents from
   Department of Public Health in Zhejiang Province (No. S2032102600032),
   Project of New Century 551 Talent Nurturing in Wenzhou, Wenzhou Science
   and Technology Bureau (No. Y20190530), in part from the University
   School of Medicine of Verona in Italy to GT and in part by the
   Southampton NIHR Biomedical Research Centre in UK (No. IS-BRC-20004 to
   CDB).
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NR 49
TC 6
Z9 6
U1 0
U2 19
PU AME PUBLISHING COMPANY
PI SHATIN
PA FLAT-RM C 16F, KINGS WING PLAZA 1, NO 3 KWAN ST, SHATIN, HONG KONG
   00000, PEOPLES R CHINA
SN 2304-3881
EI 2304-389X
J9 HEPATOBIL SURG NUTR
JI Hepatobil. Surg. Nutr.
PD OCT
PY 2023
VL 12
IS 5
BP 645
EP 657
DI 10.21037/hbsn-21-468
EA MAR 2022
PG 13
WC Gastroenterology & Hepatology; Nutrition & Dietetics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Nutrition & Dietetics; Surgery
GA U5EH6
UT WOS:000813255400001
PM 37886189
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Mendes, NP
   Ribeiro, PVM
   Alfenas, RCG
AF Mendes, Nelia P.
   Ribeiro, Priscila V. M.
   Alfenas, Rita C. G.
TI Does dietary fat affect advanced glycation end products and their
   receptors? A systematic review of clinical trials
SO NUTRITION REVIEWS
LA English
DT Review
DE advanced glycation end products; chronic diseases; Mediterranean diet;
   soluble receptor for advanced glycation end products; Western diet
ID VIRGIN OLIVE OIL; MEDITERRANEAN DIET; INSULIN-RESISTANCE; METABOLIC
   SYNDROME; GENE-EXPRESSION; OXIDANT STRESS; NADPH OXIDASE; ELDERLY-MEN;
   KAPPA-B; ACID
AB Context Dietary fat seems to affect advanced glycation end products (AGEs) and their receptors. This systematic review assesses studies that evaluated the effect of dietary fat on markers of glycation. Objective The aim of this systematic review was to analyze the effect of dietary fat on markers of glycation and to explore the mechanisms involved. Data Sources This study was conducted according to PRISMA guidelines. PubMed, Cochrane, and Scopus databases were searched, using descriptors related to dietary fat, AGEs, and the receptors for AGEs. Study Selection Studies were selected independently by the 3 authors. Divergent decisions were resolved by consensus. All studies that evaluated the effects of the quantity and quality of dietary fat on circulating concentrations of AGEs and their receptors in adults and elderly adults with or without chronic diseases were included. Initially, 9 studies met the selection criteria. Data Extraction Three authors performed data extraction independently. Six studies were included. Results Consumption of a Mediterranean diet rich in monounsaturated fatty acids (MUFAs) and low in dietary AGEs reduced serum concentrations of AGEs, reduced expression of the receptor for AGE (RAGE), and increased expression of the AGE receptor 1 (AGER1) when compared with consumption of a Western diet rich in saturated fatty acids and dietary AGEs. Supplementation with omega-3 polyunsaturated fatty acids (PUFAs) resulted in decreased concentrations of fluorescent AGEs and decreased expression of RAGE as well as increased expression of AGER1. Conclusions Increased consumption of MUFAs and omega-3 PUFAs and reduced consumption of saturated fatty acids seem to be effective strategies to beneficially affect glycation markers, which in turn may prevent and control chronic diseases. Systematic Review Registration PROSPERO registration number CRD42021220489.
C1 [Mendes, Nelia P.; Ribeiro, Priscila V. M.; Alfenas, Rita C. G.] Univ Fed Vicosa, Dept Nutr & Hlth, Campus Univ S-N,Ave Peter Henry Rolfs, BR-36570900 Vicosa, MG, Brazil.
C3 Universidade Federal de Vicosa
RP Mendes, NP (corresponding author), Univ Fed Vicosa, Dept Nutr & Hlth, Campus Univ S-N,Ave Peter Henry Rolfs, BR-36570900 Vicosa, MG, Brazil.
EM neliamendes.nut@gmail.com
RI de Melo Ribeiro, Priscila/AAO-8190-2020
OI Alfenas, Rita/0000-0003-2290-1611
FU Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES,
   Brazil) [001]; Conselho Nacional de Desenvolvimento Cientifico e
   Tecnologico (CNPq) [302851/2019-4]
FX The authors thank the Coordenacao de Aperfeicoamento de Pessoal de
   N~ivel Superior (CAPES, Brazil, funding code 001) (N.P.M. and P.V.M.R.)
   and the Conselho Nacional de Desenvolvimento Cientifico e Tecnologico
   (CNPq) (Research Productivity Grant 302851/2019-4 to R.C.G.A.) for
   financial support.
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NR 67
TC 10
Z9 10
U1 0
U2 16
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0029-6643
EI 1753-4887
J9 NUTR REV
JI Nutr. Rev.
PD FEB 10
PY 2022
VL 80
IS 3
BP 598
EP 612
DI 10.1093/nutrit/nuab095
EA DEC 2021
PG 15
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nutrition & Dietetics
GA YW7GT
UT WOS:000753584100019
PM 34871448
DA 2025-06-11
ER

PT J
AU Yang, KD
   Xu, MY
   Cao, JY
   Zhu, Q
   Rahman, M
   Holmén, BA
   Fukagawa, NK
   Zhu, JJ
AF Yang, Kundi
   Xu, Mengyang
   Cao, Jingyi
   Zhu, Qi
   Rahman, Monica
   Holmen, Britt A.
   Fukagawa, Naomi K.
   Zhu, Jiangjiang
TI Ultrafine particles altered gut microbial population and metabolic
   profiles in a sex-specific manner in an obese mouse model
SO SCIENTIFIC REPORTS
LA English
DT Article
ID PARTICULATE AIR-POLLUTION; DIESEL-ENGINE; BIODIESEL BLENDS; DIETARY
   FIBER; MATTER; INFLAMMATION; ASSOCIATION; IMMUNITY; EXPOSURE; FINE
AB Emerging evidence has highlighted the connection between exposure to air pollution and the increased risk of obesity, metabolic syndrome, and comorbidities. Given the recent interest in studying the effects of ultrafine particle (UFP) on the health of obese individuals, this study examined the effects of gastrointestinal UFP exposure on gut microbial composition and metabolic function using an in vivo murine model of obesity in both sexes. UFPs generated from light-duty diesel engine combustion of petrodiesel (B0) and a petrodiesel/biodiesel fuel blend (80:20 v/v, B20) were administered orally. Multi-omics approaches, including liquid chromatography-mass spectrometry (LC-MS) based targeted metabolomics and 16S rRNA gene sequence analysis, semi-quantitatively compared the effects of 10-day UFP exposures on obese C57B6 mouse gut microbial population, changes in diversity and community function compared to a phosphate buffer solution (PBS) control group. Our results show that sex-specific differences in the gut microbial population in response to UFP exposure can be observed, as UFPs appear to have a differential impact on several bacterial families in males and females. Meanwhile, the alteration of seventy-five metabolites from the gut microbial metabolome varied significantly (ANOVA p<0.05) across the PBS control, B0, and B20 groups. Multivariate analyses revealed that the fuel-type specific disruption to the microbial metabolome was observed in both sexes, with stronger disruptive effects found in females in comparison to male obese mice. Metabolic signatures of bacterial cellular oxidative stress, such as the decreased concentration of nucleotides and lipids and increased concentrations of carbohydrate, energy, and vitamin metabolites were detected. Furthermore, blood metabolites from the obese mice were differentially affected by the fuel types used to generate the UFPs (B0 vs. B20).
C1 [Yang, Kundi; Xu, Mengyang; Cao, Jingyi; Rahman, Monica] Miami Univ, Dept Chem & Biochem, Oxford, OH 45056 USA.
   [Zhu, Qi] Miami Univ, Dept Biol, Oxford, OH 45056 USA.
   [Holmen, Britt A.] Univ Vermont, Sch Engn, Burlington, VT 05405 USA.
   [Fukagawa, Naomi K.] USDA ARS, Beltsville Human Nutr Res Ctr, Beltsville, MD 20705 USA.
   [Zhu, Jiangjiang] Ohio State Univ, Dept Human Sci, 302D Wiseman Hall,400 W 12th Ave, Columbus, OH 43210 USA.
   [Zhu, Jiangjiang] Ohio State Univ, James Comprehens Canc Ctr, Columbus, OH 43210 USA.
C3 University System of Ohio; Miami University; University System of Ohio;
   Miami University; University of Vermont; United States Department of
   Agriculture (USDA); University System of Ohio; Ohio State University;
   James Cancer Hospital & Solove Research Institute; University System of
   Ohio; Ohio State University
RP Zhu, JJ (corresponding author), Ohio State Univ, Dept Human Sci, 302D Wiseman Hall,400 W 12th Ave, Columbus, OH 43210 USA.; Zhu, JJ (corresponding author), Ohio State Univ, James Comprehens Canc Ctr, Columbus, OH 43210 USA.
EM zhu.2484@osu.edu
RI Cao, Jingyi/HHZ-6677-2022; Xu, Meng/HJY-7139-2023; Yang,
   Kundi/GPR-7342-2022; Zhu, Qi/KYR-6238-2024; Zhu, Jiangjiang/E-4202-2013;
   Holmen, Britt/L-9865-2013
FU National Institute of General Medical Sciences of the National
   Institutes of Health [R35GM133510]
FX This study was partially supported by the National Institute of General
   Medical Sciences of the National Institutes of Health under Award Number
   R35GM133510 (to J.Z.). The authors would like to thank Dr. Yanxue Han
   (UVM) for quantifying raw impinger UFP concentrations. The authors thank
   Weihao Chen from Miami University Department of Chemical Paper
   Biomedical Engineering for help with the data analysis by R.
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NR 81
TC 4
Z9 5
U1 0
U2 8
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD MAR 25
PY 2021
VL 11
IS 1
AR 6906
DI 10.1038/s41598-021-85784-4
PG 14
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA RG7GF
UT WOS:000635701800021
PM 33767227
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Silva, OA
   Ribeiro, HV
   Avelino, TM
   Tittanegro, TH
   Figueira, ACM
   Rabelo, LA
   Pitta, ID
   Lahlou, S
   Duarte, GP
AF Silva, Odair Alves
   Ribeiro-Filho, Helder Veras
   Avelino, Thayna Mendonca
   Tittanegro, Thais Helena
   Figueira, Ana Carolina Migliorini
   Rabelo, Luiza Antas
   Pitta, Ivan da Rocha
   Lahlou, Saad
   Duarte, Gloria Pinto
TI GQ-130, a novel analogue of thiazolidinedione, improves obesity-induced
   metabolic alterations in rats: Evidence for the involvement of PPARβ/δ
   pathway
SO CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
LA English
DT Article
DE GQ-130; high-fat diet; metabolic syndrome; PPAR beta; delta;
   thiazolidinediones
ID ACTIVATED-RECEPTOR-GAMMA; DIET-INDUCED OBESITY; HIGH-FAT; ENDOTHELIAL
   DYSFUNCTION; INSULIN SENSITIZATION; PREVENTS HYPERTENSION;
   ENERGY-METABOLISM; OXIDATIVE STRESS; PROLIFERATOR; AGONIST
AB The present investigation aimed to characterize the effect of a short-time treatment with a new thiazolidinedione (TZD) derivative, GQ-130, on metabolic alterations in rats fed a high-fat diet (HFD). We investigated whether metabolic alterations induced by GQ-130 were mediated though a mechanism that involves PPAR beta/delta transactivation. Potential binding and transactivation of PPAR alpha, PPAR beta/delta or PPAR gamma by GQ-130 were examined through cell transactivation, 8-anilino-1-naphthalenesulfonic acid (ANS) fluorescence quenching assays and thermal shift assay. For in vivo experiments, male 8-week-old Wistar rats were divided into three groups fed for 6 weeks with: (a) a standard rat chow (14% fat) (control group), (b) a HFD (57.8% fat) alone (HFD group), or (c) a HFD associated with an oral treatment with GQ-130 (10 mg/kg/d) during the last week (HFD-GQ group). In 293T cells, unlike rosiglitazone, GQ-130 did not cause significant transactivation of PPAR gamma but was able to activate PPAR beta/delta by 153.9 folds in comparison with control values (DMSO). Surprisingly, ANS fluorescence quenching assay reveals that GQ-130 does not bind directly to PPAR beta/delta binding site, a finding that was further corroborated by thermal shift assay which evaluates the thermal stability of PPAR beta/delta in the presence of GQ-130. Compared to the control group, rats of the HFD group showed obesity, increased systolic blood pressure (SBP), insulin resistance, impaired glucose intolerance, hyperglycaemia, and dyslipidaemia. GQ-130 treatment abolished the increased SBP and improved all metabolic dysfunctions observed in the HFD group. Oral treatment with GQ-130 was effective in improving HFD-induced metabolic alterations probably through a mechanism that involves PPAR beta/delta activation.
C1 [Silva, Odair Alves; Duarte, Gloria Pinto] Univ Fed Pernambuco, Dept Physiol & Pharmacol, Ave Prof Moraes Rego,1235 Cidade Univ, BR-50670901 Recife, PE, Brazil.
   [Ribeiro-Filho, Helder Veras; Avelino, Thayna Mendonca; Tittanegro, Thais Helena; Figueira, Ana Carolina Migliorini] Brazilian Assoc Synchrotron Light Technol, Natl Inst Biosci, Campinas, SP, Brazil.
   [Rabelo, Luiza Antas] Univ Fed Alagoas, Inst Biol Sci & Hlth, Maceio, Alagoas, Brazil.
   [Pitta, Ivan da Rocha] Univ Fed Pernambuco, Core Therapeut Innovat, Recife, PE, Brazil.
   [Lahlou, Saad] Univ Fed Ceara, Sch Med, Dept Physiol & Pharmacol, Fortaleza, Ceara, Brazil.
C3 Universidade Federal de Pernambuco; Laboratorio Nacional de Luz
   Sincrotron (LNLS); Universidade Federal de Alagoas; Universidade Federal
   de Pernambuco; Universidade Federal do Ceara
RP Duarte, GP (corresponding author), Univ Fed Pernambuco, Dept Physiol & Pharmacol, Ave Prof Moraes Rego,1235 Cidade Univ, BR-50670901 Recife, PE, Brazil.
EM duarteg@ufpe.br
RI Ribeiro-Filho, Helder/LBH-1773-2024; Rabêlo, Luiza/S-4050-2019; Lahlou,
   Saad/C-5827-2013; Figueira, Ana/X-1649-2019
OI Ribeiro-Filho, Helder/0000-0001-8471-207X; Avelino,
   Thayna/0000-0003-3808-5743
FU Fundacao de Amparo a Ciencia e Tecnologia do Estado de Pernambuco
   [FACEPE] [APQ 07804.03/08 Pronex]; Fundacao de Amparo a Pesquisa do
   Estado de Sao Paulo [FAPESP] [22246-0]; Coordenacao de Aperfeicoamento
   de Pessoal de Nivel Superior [CAPES] [23038.006737/2012-56]
FX This work was supported by the "Fundacao de Amparo a Ciencia e
   Tecnologia do Estado de Pernambuco" [FACEPE, grant number APQ
   07804.03/08 Pronex], the "Fundacao de Amparo a Pesquisa do Estado de Sao
   Paulo [FAPESP, grant number 22246-0] and the "Coordenacao de
   Aperfeicoamento de Pessoal de Nivel Superior" [CAPES, grant number
   23038.006737/2012-56]. The present in vivo study is part of a Master
   Dissertation developed by Odair Alves Silva in order to obtain his
   Master degree in Biochemistry and Physiology at the Federal University
   of Pernambuco, Recife, Brazil.
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NR 52
TC 3
Z9 3
U1 0
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0305-1870
EI 1440-1681
J9 CLIN EXP PHARMACOL P
JI Clin. Exp. Pharmacol. Physiol.
PD MAY
PY 2020
VL 47
IS 5
BP 798
EP 808
DI 10.1111/1440-1681.13252
EA JAN 2020
PG 11
WC Pharmacology & Pharmacy; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Physiology
GA KY5OV
UT WOS:000509103200001
PM 31909493
DA 2025-06-11
ER

PT J
AU Ozkan, H
   Topsakal, S
   Ozmen, O
AF Ozkan, Halis
   Topsakal, Senay
   Ozmen, Ozlem
TI Investigation of the diabetic effects of maternal high-glucose diet on
   rats
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Article
DE Diabetes; Table sugar; Pregnancy; Insulin; Pancreas
ID METABOLIC SYNDROME; OXIDATIVE STRESS; OBESITY; ADIPOSITY; LEADS
AB Background: Diabetes mellitus become an epidemic problem throughout the world. Relation of the diabetes with diet is known. Some evidence is reported about mother died and risk of diabetes in babies during the life related with gestational diabetes. This study was conducted to examine the effects of the exposure of high-dose sucrose to rats and pups during pregnancy and lactation.
   Methods: The mother rats were categorized into four groups, during pregnancy and until the offspring were 1-month-old, as follows: Group 1, provided with normal drinking water; Group 2, provided with water containing 10%; Group 3, 20%; and Group 4, 30% table sugar. During the study, the weights and daily fluid consumption of the animals were recorded. At the end of the study, the changes in blood, urine, and pancreatic tissues of the rats were examined.
   Results: The pups in the groups supplemented with sugar had more weight gain than those of the control group. Although serum glucose levels of mothers and young rats in the groups fed with sugar-containing water did not reach the diabetic limits, it was observed that these animals had statistically significantly higher blood glucose levels than those in the control group. Insulin levels were also similarly increased by an increase in the amount of sugar. Immunohistochemical studies on the mother rats showed that insulin secreted cell numbers and insulin receptors significantly decreased in some pancreatic islets in the groups supplemented with sugar. Glucagon immunoreactivity examination showed that the number of glucagon-expressing cells decreased in the rat groups supplemented with sugar. Similar and more severe findings were observed in the offspring.
   Conclusion: This study has experimentally demonstrated that high daily intake of sugar in healthy pregnancies causes adverse effects on the mother and offspring.
C1 [Ozkan, Halis; Topsakal, Senay] Pamukkale Univ, Med Fac, Dept Endocrinol & Metab, Kinikli Campus, Denizli, Turkey.
   [Ozmen, Ozlem] Mehmet Akif Ersoy Univ, Dept Pathol, Fac Vet Med, Burdur, Turkey.
C3 Pamukkale University; Mehmet Akif Ersoy University
RP Topsakal, S (corresponding author), Pamukkale Univ, Med Fac, Dept Endocrinol & Metab, Kinikli Campus, Denizli, Turkey.
EM stopsakal@pau.edu.tr
RI Ozmen, Ozlem/GQR-2698-2022; Topsakal, Senay/JYP-8156-2024
OI Ozmen, Ozlem/0000-0002-1835-1082
FU Scientific Projects Commission of the University of Pamukkale
   [2017TIPF017]
FX This study was supported by the Scientific Projects Commission of the
   University of Pamukkale (Project number: 2017TIPF017).
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NR 22
TC 8
Z9 8
U1 0
U2 8
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD FEB
PY 2019
VL 110
BP 609
EP 617
DI 10.1016/j.biopha.2018.12.011
PG 9
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA HG3MW
UT WOS:000454879800065
PM 30537678
OA gold
DA 2025-06-11
ER

PT J
AU Muñoz-Muñoz, E
   Krause, BJ
   Uauy, R
   Casanello, P
AF Munoz-Munoz, Estefania
   Krause, Bernardo J.
   Uauy, Ricardo
   Casanello, Paola
TI LGA-newborn from patients with pregestational obesity present reduced
   adiponectin-mediated vascular relaxation and endothelial dysfunction in
   fetoplacental arteries
SO JOURNAL OF CELLULAR PHYSIOLOGY
LA English
DT Article
DE adiponectin; fetal programming; LGA; maternal obesity; placental
   vascular reactivity
ID LONG-TERM HEALTH; BODY-MASS INDEX; NITRIC-OXIDE; MATERNAL OBESITY;
   OXIDATIVE STRESS; GESTATIONAL-AGE; UMBILICAL ARTERIES; METABOLIC
   SYNDROME; GENE-EXPRESSION; ENOS EXPRESSION
AB Maternal obesity is associated with large-for-gestational-age (LGA) neonates and programming of obesity-related cardiovascular disease in the offspring, however, the mechanisms that lead to the later are unclear. Presently, interpretations of NO-dependent changes in vascular function in LGA newborn from obese mothers are conflicting. Adiponectin improves endothelial function by increasing eNOS activity and NO production. We propose that LGAs from obese mothers present a diminished vascular response to adiponectin; thus, affecting eNOS and AMPK activation. Chorionic arteries, umbilical cord and primary cultures of umbilical artery endothelial cells (HUAEC) were collected at term (>38 weeks) from uncomplicated singleton pregnancies of LGA and adequate-for-gestational (AGA) newborn. Vascular reactivity of chorionic plate arteries was assessed by wire myography. mRNA expression of adiponectin receptors 1 (AdipoR1) and AdipoR2 in HUAEC was determined by qPCR. Protein expression of AdipoR1, AdipoR2, AMPK, phospho-AMPK(Thr172), eNOS, and phospho-eNOS(Ser1177) after stimulation with AdipoRon was determined by Western Blot. Maximal adiponectin-induced chorionic artery relaxation in LGAs was diminished compared to control. In vitro studies showed no differences in expression of AdipoRs, total AMPK and, eNOS activation between groups; however, higher expression of total eNOS and AMPK activation in HUAEC of LGA relative to AGAs were observed. LGA HUAEC showed diminished NO production and eNOS activity compared to AGA in response to AdipoRon but no changes in AMPK activation. Placental endothelium of LGAs shows a diminished vascular response to adiponectin. Moreover, eNOS activation and adiponectin-dependent NO production is lower in HUAEC of LGA from obese mothers, indicating they present dysfuncional placental-endothelial responses.
C1 [Munoz-Munoz, Estefania] Univ Chile, PhD Program Nutr & Food, Santiago, Chile.
   [Krause, Bernardo J.; Uauy, Ricardo; Casanello, Paola] Pontificia Univ Catolica Chile, Sch Med, Div Pediat, Santiago, Chile.
   [Casanello, Paola] Pontificia Univ Catolica Chile, Sch Med, Div Obstet & Gynecol, Santiago, Chile.
C3 Universidad de Chile; Pontificia Universidad Catolica de Chile;
   Pontificia Universidad Catolica de Chile
RP Casanello, P (corresponding author), Pontificia Univ Catolica Chile, Sch Med, Div Obstet & Gynecol, Div Pediat, Marcoleta 391, Santiago, Chile.
EM pcasane@uc.cl
RI Casanello, Paola/X-7443-2019; Krause, Bernardo/F-4977-2013
OI Krause, Bernardo/0000-0002-3563-6143; Casanello,
   Paola/0000-0002-2355-1476
FU Fondo Nacional de Desarrollo Cientifico y Tecnologico (FONDECYT)
   [1130277, 1130801, 1171406]
FX Fondo Nacional de Desarrollo Cientifico y Tecnologico (FONDECYT), Grant
   numbers: 1130277, 1130801, 1171406
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NR 63
TC 12
Z9 12
U1 0
U2 15
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0021-9541
EI 1097-4652
J9 J CELL PHYSIOL
JI J. Cell. Physiol.
PD OCT
PY 2018
VL 233
IS 10
BP 6723
EP 6733
DI 10.1002/jcp.26499
PG 11
WC Cell Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Physiology
GA GM7GX
UT WOS:000438352300037
PM 29377113
DA 2025-06-11
ER

PT J
AU La Favor, JD
   Dubis, GS
   Yan, HM
   White, JD
   Nelson, MAM
   Anderson, EJ
   Hickner, RC
AF La Favor, Justin D.
   Dubis, Gabriel S.
   Yan, Huimin
   White, Joseph D.
   Nelson, Margaret A. M.
   Anderson, Ethan J.
   Hickner, Robert C.
TI Microvascular Endothelial Dysfunction in Sedentary, Obese Humans Is
   Mediated by NADPH Oxidase Influence of Exercise Training
SO ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
LA English
DT Article
DE acetylcholine; hydrogen peroxide; microdialysis; obesity; superoxide
ID NONINVASIVE VASCULAR FUNCTION; HUMAN SKELETAL-MUSCLE; OXIDATIVE STRESS;
   NITRIC-OXIDE; METABOLIC SYNDROME; NAD(P)H OXIDASE; RISK-FACTORS;
   BLOOD-FLOW; PROSPECTIVE COHORT; PHYSICAL-ACTIVITY
AB Objective-The objectives of this study were to determine the impact of in vivo reactive oxygen species (ROS) on microvascular endothelial function in obese human subjects and the efficacy of an aerobic exercise intervention on alleviating obesity-associated dysfunctionality.
   Approach and Results-Young, sedentary men and women were divided into lean (body mass index 18-25; n=14), intermediate (body mass index 28-32.5; n=13), and obese (body mass index 33-40; n=15) groups. A novel microdialysis technique was utilized to detect elevated interstitial hydrogen peroxide (H2O2) and superoxide levels in the vastus lateralis of obese compared with both lean and intermediate subjects. Nutritive blood flow was monitored in the vastus lateralis via the microdialysis-ethanol technique. A decrement in acetylcholine-stimulated blood flow revealed impaired microvascular endothelial function in the obese subjects. Perfusion of apocynin, an NADPH oxidase inhibitor, lowered (normalized) H2O2 and superoxide levels, and reversed microvascular endothelial dysfunction in obese subjects. After 8 weeks of exercise, H2O2 levels were decreased in the obese subjects and microvascular endothelial function in these subjects was restored to levels similar to lean subjects. Skeletal muscle protein expression of the NADPH oxidase subunits p22(phox), p47(phox), and p67(phox) was increased in obese relative to lean subjects, where p22(phox) and p67(phox) expression was attenuated by exercise training in obese subjects.
   Conclusions-This study implicates NADPH oxidase as a source of excessive ROS production in skeletal muscle of obese individuals and links excessive NADPH oxidase-derived ROS to microvascular endothelial dysfunction in obesity. Furthermore, aerobic exercise training proved to be an effective strategy for alleviating these maladies.
C1 [La Favor, Justin D.; Dubis, Gabriel S.; Yan, Huimin; White, Joseph D.; Hickner, Robert C.] East Carolina Univ, Human Performance Lab, Dept Kinesiol, Greenville, NC USA.
   [Nelson, Margaret A. M.; Anderson, Ethan J.] East Carolina Univ, Dept Pharmacol & Toxicol, Greenville, NC USA.
   [Hickner, Robert C.] East Carolina Univ, Dept Physiol, Greenville, NC USA.
   [La Favor, Justin D.; Nelson, Margaret A. M.; Anderson, Ethan J.; Hickner, Robert C.] East Carolina Univ, East Carolina Diabet & Obes Inst, Greenville, NC USA.
   [Hickner, Robert C.] East Carolina Univ, Ctr Hlth Dispar, Greenville, NC USA.
   [La Favor, Justin D.] Johns Hopkins Sch Med, James Buchannan Brady Urol Inst, Dept Urol, Baltimore, MD USA.
   [Anderson, Ethan J.] Univ Iowa, Coll Pharm, Dept Pharmaceut Sci & Expt Therapeut, Iowa City, IA 52242 USA.
   [Hickner, Robert C.] Univ KwaZulu Natal, Dept Biokinet Exercise & Leisure Sci, Durban, South Africa.
C3 University of North Carolina; East Carolina University; University of
   North Carolina; East Carolina University; University of North Carolina;
   East Carolina University; University of North Carolina; East Carolina
   University; University of North Carolina; East Carolina University;
   Johns Hopkins University; Johns Hopkins Medicine; University of Iowa;
   University of Kwazulu Natal
RP La Favor, JD (corresponding author), Johns Hopkins Univ, Sch Med, 600 N Wolfe St,Marburg 414, Baltimore, MD 21287 USA.
EM jlafavo3@jhmi.edu
RI White, Joseph/AAF-9182-2021
OI , Margaret Nelson/0009-0005-8612-8359; hickner,
   Robert/0000-0002-2683-1617; Yan, Huimin/0000-0003-0907-1246; La Favor,
   Justin/0000-0002-0845-3421
FU American College of Sports Medicine Foundation; National Institutes of
   Health [1R15HL113854-01A1, 5R01HL122863]; Ruth L. Kirschstein National
   Research Service from the National Institutes of Health [1F32DK100082]
FX This work was supported by grants from the American College of Sports
   Medicine Foundation (J.D. La Favor) and the National Institutes of
   Health 1R15HL113854-01A1 (R.C. Hickner) and 5R01HL122863 (E.J.
   Anderson). J.D. La Favor is supported by Ruth L. Kirschstein National
   Research Service Award 1F32DK100082 from the National Institutes of
   Health.
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NR 52
TC 56
Z9 59
U1 1
U2 18
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1079-5642
EI 1524-4636
J9 ARTERIOSCL THROM VAS
JI Arterioscler. Thromb. Vasc. Biol.
PD DEC
PY 2016
VL 36
IS 12
BP 2412
EP 2420
DI 10.1161/ATVBAHA.116.308339
PG 9
WC Hematology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Hematology; Cardiovascular System & Cardiology
GA EE1KO
UT WOS:000389340500017
PM 27765769
OA Green Accepted, Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Sforza, E
   Saint Martin, M
   Thomas, T
   Collet, P
   Garet, M
   Barthélémy, JC
   Roche, F
AF Sforza, Emilia
   Saint Martin, Magali
   Thomas, Thierry
   Collet, Philippe
   Garet, Martin
   Barthelemy, Jean Claude
   Roche, Frederic
TI Risk factors of osteoporosis in healthy elderly with unrecognized
   obstructive sleep apnea: role of physical activity
SO SLEEP MEDICINE
LA English
DT Article
DE Osteoporosis; Elderly; OSA; Obesity; Metabolic factors; Physical
   activity
ID BONE-MINERAL DENSITY; BODY-MASS INDEX; POPULATION-BASED COHORT;
   POSTMENOPAUSAL WOMEN; METABOLIC SYNDROME; OXIDATIVE STRESS; MEN;
   ASSOCIATION; OBESITY; METAANALYSIS
AB Objective: Several studies suggest a relationship between bone mineral density (BMD) anthropometric and metabolic variables, and obstructive sleep apnea (OSA); all of these factors have an effect on osteoporosis (OS) risk. This cross-sectional study explores these associations in a large sample of older subjects with and without OSA.
   Methods: Volunteers were recruited from the PROgnostic indicator OF cardiovascular and cerebrovascular events survey. A total of 461 subjects, aged 68.7 +/- 0.8 years, were examined, blood samples were taken, and they were subjected to home polygraphy, assessment of daily energy expenditure (DEE), and dual-energy X-ray absorptiometry.
   Results: Osteopenia (OP) was detected in 44% of subjects at the femoral and 39% at the vertebral level, while the prevalence of OS was lower at the femoral (4%) and vertebral (12%) levels. As expected, women had a higher prevalence of OP and OS. Subjects with OP and OS had a tendency to have lower DEE and values of obesity, apnea-hypopnea index (AHI), and indices of hypoxemia (ODI). At the correlation analyses, anthropometric factors and DEE were significantly related to BMD with a slight effect of indices of OSA severity. After adjustment for confounding variables, univariate and multivariate regression analyses showed a strong significant association between femoral and lumbar BMD and T-score and DEE without contribution of metabolic data and with a slight negative effect of respiratory factors.
   Conclusions: In this sample of the elderly, physical activity was the best predictor of OS with a slight effect of body mass index. The indices of OSA confirm their protective effect on bone mineral density. (C) 2016 Elsevier B.V. All rights reserved.
C1 [Sforza, Emilia; Saint Martin, Magali; Garet, Martin; Barthelemy, Jean Claude; Roche, Frederic] Univ St Etienne, COMUE Lyon, Fac Med Jacques Lisfranc, Serv Physiol Clin & Exercice, St Etienne, France.
   [Thomas, Thierry; Collet, Philippe] Univ St Etienne, COMUE Lyon, Fac Med Jacques Lisfranc, CHU St Etienne,Inserm LBTO U1059,Serv Rhumatol, St Etienne, France.
C3 Universite Jean Monnet; CHU de St Etienne; Institut National de la Sante
   et de la Recherche Medicale (Inserm); Universite Jean Monnet
RP Sforza, E (corresponding author), CHU Nord, Serv Physiol Clin & Exercice, Niveau 6, F-42055 St Etienne, France.
EM emilia.sforza@gmail.com
RI Barthelemy, Jean-Claude/AAE-7180-2019; Thomas, Thierry/JZE-4328-2024
OI Roche, Frederic/0000-0001-6115-7958; Barthelemy,
   Jean-Claude/0000-0003-4306-7275
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NR 47
TC 11
Z9 11
U1 0
U2 24
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1389-9457
EI 1878-5506
J9 SLEEP MED
JI Sleep Med.
PD JUN
PY 2016
VL 22
BP 25
EP 32
DI 10.1016/j.sleep.2016.04.010
PG 8
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA DU6EI
UT WOS:000382306400005
PM 27544832
DA 2025-06-11
ER

PT J
AU d'Uscio, LV
   He, TR
   Santhanam, AVR
   Tai, LJ
   Evans, RM
   Katusic, ZS
AF d'Uscio, Livius V.
   He, Tongrong
   Santhanam, Anantha Vijay R.
   Tai, Li-Jung
   Evans, Ronald M.
   Katusic, Zvonimir S.
TI Mechanisms of vascular dysfunction in mice with endothelium-specific
   deletion of the PPAR-δ gene
SO AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
LA English
DT Article
DE endothelial dysfunction; nitric oxide; tetrahydrobiopterin; carotid
   artery; hydrogen peroxide; peroxisome proliferator-activated
   receptor-delta; endothelial nitric oxide synthase
ID ACTIVATED-RECEPTOR-DELTA; NITRIC-OXIDE SYNTHASE; GTP-CYCLOHYDROLASE I;
   HYDROGEN-PEROXIDE; TETRAHYDROBIOPTERIN LEVELS; ACID OXIDATION; CATALASE;
   CELLS; OVEREXPRESSION; RELAXATIONS
AB Peroxisome proliferator-activated receptor (PPAR)-delta is a nuclear hormone receptor that is mainly involved in lipid metabolism. Recent studies have suggested that PPAR-delta agonists exert vascular protective effects. The present study was designed to characterize vascular function in mice with genetic inactivation of PPAR-delta in the endothelium. Mice with vascular endothelial cell-specific deletion of the PPAR-delta gene (ePPAR delta(-/-) mice) were generated using loxP/Cre technology. ePPAR delta(-/-) mice were normotensive and did not display any sign of metabolic syndrome. Endothelium-dependent relaxations to ACh and endothelium-independent relaxations to the nitric oxide (NO) donor diethylammonium (Z)-1-(N,N-diethylamino) diazen-1-ium-1,2-diolate were both significantly impaired in the aorta and carotid arteries of ePPAR delta(-/-) mice (P < 0.05). In ePPAR delta(-/-) mouse aortas, phosphorylation of endothelial NO synthase at Ser(1177) was significantly decreased (P < 0.05). However, basal levels of cGMP were unexpectedly increased (P < 0.05). Enzymatic activity of GTP-cyclohydrolase I and tetrahydrobiopterin levels were also enhanced in ePPAR delta(-/-) mice (P < 0.05). Most notably, endothelium-specific deletion of the PPAR-delta gene significantly decreased protein expressions of catalase and glutathione peroxidase 1 and resulted in increased levels of H2O2 in the aorta (P < 0.05). In contrast, superoxide anion production was unaltered. Moreover, treatment with catalase prevented the endothelial dysfunction and elevation of cGMP detected in aortas of ePPAR delta(-/-) mice. The findings suggest that increased levels of cGMP caused by H2O2 impair vasodilator reactivity to endogenous and exogenous NO. We speculate that chronic elevation of H2O2 predisposes PPAR-delta-deficient arteries to oxidative stress and vascular dysfunction.
C1 [d'Uscio, Livius V.; He, Tongrong; Santhanam, Anantha Vijay R.; Katusic, Zvonimir S.] Mayo Clin, Coll Med, Dept Anesthesiol, Rochester, MN 55905 USA.
   [d'Uscio, Livius V.; He, Tongrong; Santhanam, Anantha Vijay R.; Katusic, Zvonimir S.] Mayo Clin, Coll Med, Dept Mol Pharmacol & Expt Therapeut, Rochester, MN 55905 USA.
   [Tai, Li-Jung; Evans, Ronald M.] Salk Inst Biol Studies, Howard Hughes Med Inst, Gene Express Lab, La Jolla, CA 92037 USA.
C3 Mayo Clinic; Mayo Clinic; Howard Hughes Medical Institute; Salk
   Institute
RP Katusic, ZS (corresponding author), Mayo Clin, Dept Anesthesiol, 200 First St SW, Rochester, MN 55905 USA.
EM Katusic.Zvonimir@mayo.edu
RI Evans, Ronald/AAF-4001-2019
OI d'Uscio, Livius/0000-0001-9577-9480; Evans, Ronald/0000-0002-9986-5965
FU National Institutes of Health (NIH) [HL-91867, HL-111062]; Mayo
   Foundation; NIH [HL-088093, DK-057978, DK-090962, HL-105278, ES-010337];
   Glenn Foundation for Medical Research; Leona M. and Harry B. Helmsley
   Charitable Trust; Ipsen/Biomeasure; California Institute for
   Regenerative Medicine; Ellison Medical Foundation; Howard Hughes Medical
   Institute
FX This work was supported by National Institutes of Health (NIH) Grants
   HL-91867 and HL-111062 and the Mayo Foundation (to Z. S. Katusic) and by
   NIH Grants HL-088093, DK-057978, DK-090962, HL-105278, and ES-010337,
   the Glenn Foundation for Medical Research, the Leona M. and Harry B.
   Helmsley Charitable Trust, Ipsen/Biomeasure, the California Institute
   for Regenerative Medicine, The Ellison Medical Foundation, and the
   Howard Hughes Medical Institute (to R. M. Evans). R. M. Evans is an
   Investigator of the Howard Hughes Medical Institute at the Salk
   Institute and March of Dimes Chair in Molecular and Developmental
   Biology.
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   Zemse SM, 2010, AM J PHYSIOL-HEART C, V299, pH1160, DOI 10.1152/ajpheart.00763.2009
NR 56
TC 20
Z9 21
U1 0
U2 3
PU AMER PHYSIOLOGICAL SOC
PI Rockville
PA 6120 Executive Blvd, Suite 600, Rockville, MD, UNITED STATES
SN 0363-6135
EI 1522-1539
J9 AM J PHYSIOL-HEART C
JI Am. J. Physiol.-Heart Circul. Physiol.
PD APR
PY 2014
VL 306
IS 7
BP H1001
EP H1010
DI 10.1152/ajpheart.00761.2013
PG 10
WC Cardiac & Cardiovascular Systems; Physiology; Peripheral Vascular
   Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Physiology
GA AE6CV
UT WOS:000334077400008
PM 24486511
OA Green Published
DA 2025-06-11
ER

PT J
AU Miao, YL
   Ren, JM
   Jiang, L
   Liu, JB
   Jiang, B
   Zhang, XL
AF Miao, Yulian
   Ren, Jianmin
   Jiang, Ling
   Liu, Jinbo
   Jiang, Bei
   Zhang, Xiaoli
TI α-lipoic acid attenuates obesity-associated hippocampal
   neuroinflammation and increases the levels of brain-derived neurotrophic
   factor in ovariectomized rats fed a high-fat diet
SO INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
LA English
DT Article
DE alpha-lipoic acid; obesity; hippocampus; inflammation; brain-derived
   neurotrophic factor
ID ENDOPLASMIC-RETICULUM STRESS; ACTIVATED PROTEIN-KINASE;
   INSULIN-RESISTANCE; ALZHEIMERS-DISEASE; SYNAPTIC PLASTICITY; METABOLIC
   SYNDROME; SYSTEMIC INFLAMMATION; MEMORY; MICE; EXPRESSION
AB Overweight or obesity in post-menopausal women is known to induce metabolic disorders associated with neuroinflammation. alpha-lipoic acid (alpha-LA), which has been clinically used to treat diabetic peripheral neuropathy, has been found to exert anti-inflammatory and neuroprotective effects in patients with Alzheimer's disease (AD). In this study, to investigate the effects of alpha-LA on neuroinflammatory factors and the levels of hippocampal brain-derived neurotrophic factor (BDNF) in ovariectomized rats fed a high-fat diet (HFD), Wistar ovariectomized rats were fed HFD alone or HFD and treated with alpha-LA for 12 weeks. Metabolic parameters in serum were detected, real-time polymerase chain reaction (RT-PCR), western blot analysis and ELISA were used to evaluate the levels of inflammatory factors and BDNF in the hippocampus. alpha-LA markedly reduced body weight, the levels of serum total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C), as well as the levels of leptin and insulin resistance in ovariectomized rats fed HFD. It also significantly increased the levels of serum adiponectin and high-density lipoprotein cholesterol (HDL-C). In the hippocampal tissues of ovariectomized rats fed HFD, the protein and mRNA expression of BDNF was upregulated following the administration of alpha-LA. Conversely, the levels of interleukin 6 (IL-6) and tumour necrosis factor-alpha (TNF-alpha) were decreased following treatment with alpha-LA. These findings demonstrate that alpha-LA significantly increases the expression of BDNF in the hippocampus of obese ovariectomized rats fed HFD, possibly by improving lipid metabolism, enhancing insulin sensitivity and reversing central inflammation.
C1 [Miao, Yulian; Ren, Jianmin; Jiang, Ling; Liu, Jinbo; Zhang, Xiaoli] Shandong Univ, Qilu Hosp, Dept Endocrinol, Jinan 250012, Shandong, Peoples R China.
   [Jiang, Bei] Shandong Univ, Qilu Hosp, Dept Nephrol, Jinan 250012, Shandong, Peoples R China.
C3 Shandong University; Shandong University
RP Zhang, XL (corresponding author), Shandong Univ, Qilu Hosp, Dept Endocrinol, 107 Wenhuaxi Rd, Jinan 250012, Shandong, Peoples R China.
EM sallyzh66@sina.com
FU promotive research fund for excellent young and middle-aged scientists
   of Shandong Province [BS2009YY038]; Independent Innovation Foundation of
   Shandong University (IIFSDU) [2012TS162]
FX This study was supported by the promotive research fund for excellent
   young and middle-aged scientists of Shandong Province (grant no.
   BS2009YY038) and The Independent Innovation Foundation of Shandong
   University (IIFSDU, grant no. 2012TS162).
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NR 43
TC 27
Z9 32
U1 0
U2 29
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1107-3756
J9 INT J MOL MED
JI Int. J. Mol. Med.
PD NOV
PY 2013
VL 32
IS 5
BP 1179
EP 1186
DI 10.3892/ijmm.2013.1482
PG 8
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 225SL
UT WOS:000324982500025
PM 24008266
OA Bronze
DA 2025-06-11
ER

PT J
AU Mann, JR
   Pan, C
   Rao, GA
   McDermott, S
   Hardin, JW
AF Mann, Joshua R.
   Pan, Chun
   Rao, Gowtham A.
   McDermott, Suzanne
   Hardin, James W.
TI Children Born to Diabetic Mothers May be More Likely to Have
   Intellectual Disability
SO MATERNAL AND CHILD HEALTH JOURNAL
LA English
DT Article
DE Intellectual disability; Maternal diabetes mellitus; Maternal and child
   health
ID METABOLIC SYNDROME; BIRTH-WEIGHT; INFLAMMATION; FETAL; CHORIOAMNIONITIS;
   POPULATION; PREVALENCE; DISEASE; STRESS; TRENDS
AB Intellectual disability (ID) is a major public health condition that usually develops in utero and causes lifelong disability. Despite improvements in pregnancy and delivery care that have resulted in dramatic decreases in infant mortality rates, the incidence of ID has remained constant over the past 20 years. There may still be uncharacterized preventable causes of ID such as Diabetes Mellitus (DM). We used statewide individual level de-identified data for maternal and child pairs obtained by linking Medicaid claims, Department of Education, and Department of Disabilities and Special Needs data from 2000 to 2007 for all mother-child pairs with a minimum follow-up of 3-years post birth or until a diagnosis of ID. To ascertain the adjusted relationship between DM and ID, we fit a logistic regression model taking into account individual level clustering on mothers for multiple pregnancies using the population-averaged Generalized Estimating Equations method. Of the 162,611 eligible maternal and child pairs, 5,667 (3.49 %) of the children were diagnosed with ID between birth and 3-years of age. After adjustment for covariates the independent relationship between DM and ID was significant with odds ratio of 1.10 (1.01-1.12). On sub-analysis, patients with pre-pregnancy DM had the highest effect measure with an estimated odds ratio of 1.32 (0.84, 2.09), although this was not statistically significant. In this large cohort of mothers and children in South Carolina, we found a small but statistically significant increased risk for ID among children born to mothers with DM. Additional information about the association between maternal DM and risk of ID in children may lead to the development of effective preventive interventions on the individual and public health levels.
C1 [Mann, Joshua R.; Rao, Gowtham A.; McDermott, Suzanne] Univ S Carolina, Sch Med, Columbia, SC 29208 USA.
   [Pan, Chun; Hardin, James W.] Univ S Carolina, Arnold Sch Publ Hlth, Columbia, SC 29208 USA.
C3 University of South Carolina System; University of South Carolina
   Columbia; University of South Carolina System; University of South
   Carolina Columbia
RP Mann, JR (corresponding author), Univ S Carolina, Sch Med, Columbia, SC 29208 USA.
EM joshua.mann@uscmed.sc.edu
RI Hardin, James/P-4772-2019
OI Hardin, James/0000-0003-0506-5500
FU PHS HHS [R40MC21523] Funding Source: Medline
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NR 22
TC 16
Z9 17
U1 0
U2 3
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1092-7875
EI 1573-6628
J9 MATERN CHILD HLTH J
JI Matern. Child Health J.
PD JUL
PY 2013
VL 17
IS 5
BP 928
EP 932
DI 10.1007/s10995-012-1072-1
PG 5
WC Public, Environmental & Occupational Health
WE Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA 163FK
UT WOS:000320321100017
PM 22798077
DA 2025-06-11
ER

PT J
AU Witbracht, MG
   Van Loan, M
   Adams, SH
   Keim, NL
   Laugero, KD
AF Witbracht, Megan G.
   Van Loan, Marta
   Adams, Sean H.
   Keim, Nancy L.
   Laugero, Kevin D.
TI Dairy Food Consumption and Meal-Induced Cortisol Response Interacted to
   Influence Weight Loss in Overweight Women Undergoing a 12-Week,
   Meal-Controlled, Weight Loss Intervention
SO JOURNAL OF NUTRITION
LA English
DT Article
ID PITUITARY-ADRENAL AXIS; ALPHA-LACTALBUMIN INCREASES; NEUTRAL
   AMINO-ACIDS; OBESE WOMEN; VULNERABLE SUBJECTS; INSULIN-RESISTANCE;
   METABOLIC SYNDROME; ABDOMINAL OBESITY; PROTEIN-RICH; STRESS
AB Dairy food enhances weight loss in animal models, possibly by modifying the metabolic effects of cortisol. This study determined in overweight women (ages 20.0-45.9 y; n = 51) whether including dairy food in an energy-restricted diet affects cortisol concentrations and whether differences in provoked cortisol explain the magnitude of weight loss. Women received either an adequate amount of dairy food (AD), the equivalent of >= 711 mL/d milk, or a low amount of dairy food (LD), the equivalent to <= 238 mL/d milk, in a 12-wk, energy-restricted dietary intervention. Participants were tested in a 12-h laboratory visit, which included 2 standard meals and a dinner buffet that was consumed ad libitum. Salivary cortisol was measured from waking to bedtime. Energy restriction increased (P <= 0.04) the minimum and decreased (P <= 0.02) the diurnal amplitude in the salivary cortisol concentration from baseline to postintervention. Energy restriction enhanced the dinner meal-stimulated salivary cortisol response (DMR) (P <= 0.02) but only in the LD group. Compared with the LD treatment, the AD treatment induced (P <= 0.04) greater reductions in body weight and fat, but only in women characterized as having a baseline DMR (responders) (n = 26); weight and fat lost in the AD and LD groups were similar in nonresponders (n = 25). Overall, energy restriction dampened diurnal salivary cortisol fluctuations [symptomatic of hypothalamic-pituitary-adrenal (HPA) axis dysfunction] and enhanced dinner meal-stimulated salivary cortisol concentrations. The AD treatment prevented the latter. Furthermore, certain phenotypic markers of HPA axis function may help to expose the weight-reducing effects of consuming dairy food. J. Nutr. 143: 46-52, 2013.
C1 [Witbracht, Megan G.; Van Loan, Marta; Adams, Sean H.; Keim, Nancy L.; Laugero, Kevin D.] Univ Calif Davis, Dept Nutr, Davis, CA 95616 USA.
   [Van Loan, Marta; Adams, Sean H.; Keim, Nancy L.; Laugero, Kevin D.] ARS, USDA, Western Human Nutr Res Ctr, Obes & Metab Res Unit, Davis, CA USA.
C3 University of California System; University of California Davis; United
   States Department of Agriculture (USDA)
RP Laugero, KD (corresponding author), Univ Calif Davis, Dept Nutr, Davis, CA 95616 USA.
EM kevin.laugero@ars.usda.gov
RI ADAMS, SEAN/N-9262-2018
OI ADAMS, SEAN/0000-0002-9515-2319
FU National Dairy Council; Dairy Council of California, USDA Agricultural
   Research Service [5306-51530-006-00D, 5306-51530-019-00D]; Clinical and
   Translational Science Center of the University of California, Davis from
   the National Center for Research Resources [UL1 RR024146]
FX Supported by the National Dairy Council administered by the Dairy
   Research Institute, the Dairy Council of California, USDA Agricultural
   Research Service projects 5306-51530-006-00D and 5306-51530-019-00D, and
   Clinical and Translational Science Center of the University of
   California, Davis grant no. UL1 RR024146 from the National Center for
   Research Resources. The USDA is an equal opportunity provider and
   employer.
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NR 53
TC 15
Z9 16
U1 1
U2 17
PU AMER SOC NUTRITION-ASN
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-3166
EI 1541-6100
J9 J NUTR
JI J. Nutr.
PD JAN
PY 2013
VL 143
IS 1
BP 46
EP 52
DI 10.3945/jn.112.166355
PG 7
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 065MV
UT WOS:000313153500007
PM 23190756
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU McEniery, CM
   Spratt, M
   Munnery, M
   Yarnell, J
   Lowe, GD
   Rumley, A
   Gallacher, J
   Ben-Shlomo, Y
   Cockcroft, JR
   Wilkinson, IB
AF McEniery, Carmel M.
   Spratt, Michael
   Munnery, Margaret
   Yarnell, John
   Lowe, Gordon D.
   Rumley, Ann
   Gallacher, John
   Ben-Shlomo, Yoav
   Cockcroft, John R.
   Wilkinson, Ian B.
TI An Analysis of Prospective Risk Factors for Aortic Stiffness in Men
   20-Year Follow-Up From the Caerphilly Prospective Study
SO HYPERTENSION
LA English
DT Article
DE arterial stiffness; pulse wave velocity; aorta; blood pressure; heart
   rate
ID PULSE-WAVE VELOCITY; C-REACTIVE PROTEIN; CENTRAL BLOOD-PRESSURE;
   ARTERIAL STIFFNESS; METABOLIC SYNDROME; CARDIOVASCULAR MORTALITY;
   AUGMENTATION INDEX; SMOKING; DETERMINANTS; HYPERTENSION
AB Arterial stiffness is an important determinant of cardiovascular risk. The precise risk factors for arterial stiffening remain unclear. We aimed to identify potential risk factors using prospective exposure data from the Caerphilly Prospective Study. Aortic pulse wave velocity and augmentation index were measured in 825 men and related to current (2004) and baseline (1979-1988) anthropometric, hemodynamic, and biochemical factors. The mean age of the men was 74 years, with an average follow-up of 20 years. The only independent baseline predictors of current velocity were pulse pressure (standardized beta-coefficient: 0.58), C-reactive protein (0.35), glucose (0.25), and waist circumference (0.23). The sole baseline predictor of current augmentation index was fibrinogen (0.78). After additional adjustment for the corresponding current risk factor, pulse wave velocity was best related to cumulative exposure to C-reactive protein, whereas augmentation index was most strongly related to current levels. Velocity was also more strongly correlated with baseline levels of triglycerides and smoking but with current waist circumference. The pulse pressure heart rate product assessed over the whole of 20 years was independently correlated with aortic pulse wave velocity but not augmentation index. Other than blood pressure, established cardiovascular risk factors have only a modest effect on aortic stiffness and wave reflection. Inflammation and the level of repetitive cyclic stress are important predictors of aortic stiffness, whereas wave reflection is predicted by acute inflammation only. Adequate control of pulse pressure and heart rate, as well as reducing inflammation, may, in the long-term, retard aortic stiffening, although this remains to be tested directly. (Hypertension. 2010; 56: 36-43.)
C1 [McEniery, Carmel M.; Wilkinson, Ian B.] Univ Cambridge, Addenbrookes Hosp, Clin Pharmacol Unit, Cambridge CB2 0QQ, England.
   [Spratt, Michael; Ben-Shlomo, Yoav] Univ Bristol, Dept Social Med, Bristol, Avon, England.
   [Munnery, Margaret; Cockcroft, John R.] Wales Heart Res Inst, Dept Cardiol, Cardiff, S Glam, Wales.
   [Yarnell, John] Queens Univ, Dept Epidemiol & Publ Hlth, Belfast, Antrim, North Ireland.
   [Lowe, Gordon D.; Rumley, Ann] Univ Glasgow, Div Cardiovasc & Med Sci, Glasgow, Lanark, Scotland.
   [Gallacher, John] Cardiff Univ, Sch Med, Ctr Hlth Sci Res, Dept Primary Care & Publ Hlth, Cardiff, S Glam, Wales.
C3 University of Cambridge; Cambridge University Hospitals NHS Foundation
   Trust; Addenbrooke's Hospital; University of Bristol; Cardiff
   University; Queens University Belfast; University of Glasgow; Cardiff
   University
RP McEniery, CM (corresponding author), Univ Cambridge, Addenbrookes Hosp, Clin Pharmacol Unit, Box 110, Cambridge CB2 0QQ, England.
EM cmm41@cam.ac.uk
RI Ben-Shlomo, Yoav/ABD-2004-2021
OI wilkinson, ian/0000-0001-6598-9399; Ben-Shlomo, Yoav/0000-0001-6648-3007
FU British Heart Foundation; Cambridge Biomedical Research Centre; ESRC
   [ES/G007438/1] Funding Source: UKRI
FX This study was funded by a grant from the British Heart Foundation. C.
   M. M. is supported by a British Heart Foundation Intermediate Research
   Fellowship, and I. B. W. is supported by a British Heart Foundation
   Senior Clinical Fellowship. Both receive support from the Cambridge
   Biomedical Research Centre.
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NR 48
TC 177
Z9 195
U1 0
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0194-911X
EI 1524-4563
J9 HYPERTENSION
JI Hypertension
PD JUL 1
PY 2010
VL 56
IS 1
BP 36
EP 43
DI 10.1161/HYPERTENSIONAHA.110.150896
PG 8
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 611XX
UT WOS:000278859300010
PM 20530296
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Bianchi, C
   Penno, G
   Crisci, I
   Daniele, G
   Agostini, A
   Del Prato, S
   Miccoli, R
AF Bianchi, Cristina
   Penno, Giuseppe
   Crisci, Isabella
   Daniele, Giuseppe
   Agostini, Annalisa
   Del Prato, Stefano
   Miccoli, Roberto
TI Serum gamma-glutamyltransferase levels are related to insulin
   sensitivity and secretion in subjects with abnormal glucose regulation
SO DIABETES-METABOLISM RESEARCH AND REVIEWS
LA English
DT Article
DE glucose regulation; gamma-glutamyltransferase; insulin resistance
ID BETA-CELL FUNCTION; PERSISTENT ORGANIC POLLUTANTS; ARTERY RISK
   DEVELOPMENT; FATTY LIVER-DISEASE; ALANINE AMINOTRANSFERASE; METABOLIC
   SYNDROME; DIABETES-MELLITUS; OXIDATIVE STRESS; FASTING GLUCOSE;
   ASSOCIATION
AB Background To test the association between gamma-glutamyltransferase level and glucose regulation.
   Methods We performed a cross-sectional analysis of 500 subjects [199 men/301 women, age 47 +/- 11 years, body mass index (BMI) 28.6 +/- 5.5 kg/m(2)] referred to Diabetes Clinics because of potential risk of type 2 diabetes mellitus (T2DM).
   Results The prevalence of all glucose intolerance categories was higher in the top quartile of gamma-glutamyltransferase than in the first. Subjects with normal glucose tolerance showed lower gamma-glutamyltransferase levels compared with those with impaired glucose tolerance (IGT), impaired fasting glucose (IFG)+IGT and T2DM (ANOVA, p < 0.0001), but not those with IFG. Homeostasis model assessment-insulin resistance (HOMA-IR) increased with increasing levels of gamma-glutamyltransferase, while the insulinogenic index/HOMA-IR ratio decreased. In an age- and sex-adjusted analysis, the top gamma-glutamyltransferase quartile was independently associated with IFG+IGT [odds ratio (OR) 2.41; 95% confidence interval (CI): 1.13-5.15] and T2DM (OR 2.77; 95% CI: 1.47-5.22). After further adjustment for BMI, alcohol intake, family history of diabetes, cigarette smoking and physical activity, the top quartile of gamma-glutamyltransferase remained an independent predictor of IFG+IGT (OR 2.62; 95% CI: 1.13-6.07) and T2DM (OR 2.39; 95% CI: 1.20-4.76). Only when transaminases and HOMA-IR have been added to the model, the top quartile of gamma-glutamyltransferase resulted no more independently associated to IFG+IGT or T2DM.
   Conclusions Gamma-glutamyltransferase is closely related to insulin resistance, reduced beta-cell function and deterioration of glucose tolerance. Copyright (C) 2010 John Wiley & Sons, Ltd.
C1 [Bianchi, Cristina; Penno, Giuseppe; Crisci, Isabella; Daniele, Giuseppe; Agostini, Annalisa; Del Prato, Stefano; Miccoli, Roberto] Univ Pisa, Dept Endocrinol & Metab, Pisa, Italy.
C3 University of Pisa
RP Miccoli, R (corresponding author), Osped Cisanello, Sect Diabet, Dept Endocrinol & Metab, Via Paradisa 2, I-56126 Pisa, Italy.
EM rmiccoli@immr.med.unipi.it
RI Daniele, Giuseppe/K-9650-2016; Del Prato, Stefano/K-3405-2016; Bianchi,
   Cristina/C-2847-2018
OI Daniele, Giuseppe/0000-0001-6301-9161; Del Prato,
   Stefano/0000-0002-5388-0270; Bianchi, Cristina/0000-0003-2799-2380
FU Merck Co.; Pfilzer Inc.; Eli Lilly and Co.; Sanofi-Aventis
FX S.D.P. has served on an advisory panel for Novartis Pharmaceuticals,
   Merck & Co., Roche Pharmaceuticals, Roche Diagnostics Corporation,
   Pfizer Inc., Eli Lilly and Co., Amylin Pharmaceuticals Inc. and Mannkind
   Corporation; has received research support from Merck & Co., Pfilzer
   Inc., Eli Lilly and Co. and Sanofi-Aventis; and is a member of the
   speaker bureau for GlaxoSmithKline, Sanofi-Aventis and Novartis
   Pharmaceuticals. C.B. is a part-time consultant of Eli Lilly and Co. The
   other authors have no conflict of interest to declare.
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NR 38
TC 7
Z9 9
U1 0
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1520-7552
EI 1520-7560
J9 DIABETES-METAB RES
JI Diabetes-Metab. Res. Rev.
PD MAR
PY 2010
VL 26
IS 3
BP 181
EP 186
DI 10.1002/dmrr.1069
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 604MA
UT WOS:000278281900004
PM 20186999
DA 2025-06-11
ER

PT J
AU Sell, H
   Laurencikiene, J
   Taube, A
   Eckardt, K
   Cramer, A
   Horrighs, A
   Arner, P
   Eckel, J
AF Sell, Henrike
   Laurencikiene, Jurga
   Taube, Annika
   Eckardt, Kristin
   Cramer, Andrea
   Horrighs, Angelika
   Arner, Peter
   Eckel, Juergen
TI Chemerin Is a Novel Adipocyte-Derived Factor Inducing Insulin Resistance
   in Primary Human Skeletal Muscle Cells
SO DIABETES
LA English
DT Article
ID HUMAN ADIPOSE-TISSUE; METABOLIC SYNDROME; GLUCOSE-TOLERANCE; FAT-CELLS;
   OBESITY; EXPRESSION; ADIPONECTIN; ADIPOKINE; RECEPTOR; PROTEIN
AB OBJECTIVE-Chemerin is an adipokine that affects adipogenesis and glucose homeostasis in adipocytes and increases with BMI in humans. This study was aimed at investigating the regulation of chemerin release and its effects on glucose metabolism in skeletal muscle cells.
   RESEARCH DESIGN AND METHODS-Human skeletal muscle cells were treated with chemerin to study insulin signaling, glucose uptake, and activation of stress kinases. The release of chemerin was analyzed from in vitro differentiated human adipocytes and adipose tissue explants from 27 lean and 26 obese patients.
   RESULTS-Human adipocytes express chemerin and chemokine-like receptor 1 (CMKLR1) differentiation dependently and secrete chemerin (15 ng/ml from 10(6) cells). This process is slightly but significantly increased by tumor necrosis factor-alpha and markedly inhibited by >80% by peroxisome proliferator-activated receptor-gamma activation. Adipose tissue explants from obese patients are characterized by significantly higher chemerin secretion compared with lean control subjects (21 and 8 ng from 10(7) cells, respectively). Chemerin release is correlated with BMI, waist-to-hip ratio, and adipocyte volume. Furthermore, higher chemerin release is associated with insulin resistance at the level of lipogenesis and insulin-induced antilipolysis in adipocytes. Chemerin induces insulin resistance in human skeletal muscle cells at the level of insulin receptor substrate 1, Akt and glycogen synthase kinase 3 phosphorylation, and glucose uptake. Furthermore, chemerin activates p38 mitogen-activated protein kinase, nuclear factor-kappa B, and extracellular signal-regulated kinase (ERK)-1/2. Inhibition of ERK prevents chemerin-induced insulin resistance, pointing to participation of this pathway in chemerin action.
   CONCLUSIONS-Adipocyte-derived secretion of chemerin may be involved in the negative cross talk between adipose tissue and skeletal muscle contributing to the negative relationship between obesity and insulin sensitivity. Diabetes 58: 2731-2740, 2009
C1 [Sell, Henrike; Taube, Annika; Eckardt, Kristin; Cramer, Andrea; Horrighs, Angelika; Eckel, Juergen] German Diabet Ctr, Inst Clin Biochem & Pathobiochem, Dusseldorf, Germany.
   [Laurencikiene, Jurga; Arner, Peter] Karolinska Inst, Karolinska Univ Hosp, Dept Med, Stockholm, Sweden.
C3 Leibniz Association; Deutsches Diabetes-Zentrum (DDZ); Karolinska
   Institutet; Karolinska University Hospital
RP Sell, H (corresponding author), German Diabet Ctr, Inst Clin Biochem & Pathobiochem, Dusseldorf, Germany.
EM henrike.sell@ddz.uni-duesseldorf.de
RI Laurencikiene, Jurga/JWA-0369-2024
OI Laurencikiene, Jurga/0000-0002-7032-2924; Eckel,
   Juergen/0000-0003-3645-5288; Arner, Peter/0000-0002-6208-6220; Sell,
   Henrike/0000-0001-6323-6158
FU Ministry of Science and Research of Nordrhein-Westphalen; German Federal
   Ministry of Health; European Union COST (European Cooperation in Science
   and Technology) Action [BM0602]; Swedish Research Council; Swedish Heart
   and Lung Foundation; Swedish Diabetes Association; Commission of the
   European Communities [HEALTH-F2-2008-201100]
FX This work was supported by the Ministry of Science and Research of
   Nordrhein-Westphalen, German Federal Ministry of Health, European Union
   COST (European Cooperation in Science and Technology) Action BM0602,
   Swedish Research Council, Swedish Heart and Lung Foundation, Swedish
   Diabetes Association, and the Commission of the European Communities
   (Collaborative Project ADAPT [Adipokines as Drug Targets to Combat
   Adverse Effects of Excess Adipose Tissue] Contract no.
   HEALTH-F2-2008-201100).
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NR 46
TC 301
Z9 353
U1 0
U2 15
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0012-1797
J9 DIABETES
JI Diabetes
PD DEC
PY 2009
VL 58
IS 12
BP 2731
EP 2740
DI 10.2337/db09-0277
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 529MS
UT WOS:000272522000005
PM 19720798
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Tan, HH
   Fiel, MI
   Sun, QH
   Guo, JS
   Gordon, RE
   Chen, LC
   Friedman, SL
   Odin, JA
   Allina, J
AF Tan, Hui-Hui
   Fiel, M. Isabel
   Sun, Qinghua
   Guo, Jinsheng
   Gordon, Ronald E.
   Chen, Lung-Chi
   Friedman, Scott L.
   Odin, Joseph A.
   Allina, Jorge
TI Kupffer cell activation by ambient air particulate matter exposure may
   exacerbate non-alcoholic fatty liver disease
SO JOURNAL OF IMMUNOTOXICOLOGY
LA English
DT Article
DE Toll-like receptor; kupffer cell; steatohepatitis; fibrosis; IL-6
ID OBSTRUCTIVE PULMONARY-DISEASE; DIESEL EXHAUST PARTICLES; TOLL-LIKE
   RECEPTOR-4; SUBCHRONIC EXPOSURES; POLLUTION PARTICLES;
   ENDOTHELIAL-CELLS; HEPATIC-FIBROSIS; OXIDATIVE STRESS; MICE;
   STEATOHEPATITIS
AB Owing to increased obesity, non-alcoholic fatty liver disease (NAFLD) is now the most prevalent liver disease in the United States. NAFLD is considered a component of metabolic syndrome, a cluster of disorders that also includes diabetes mellitus, dyslipidemia, arteriosclerosis, and hypertension. Exposure to ambient air particulate matter with aerodynamic diameters < 2.5 mu m (PM2.5) is a risk factor for arteriosclerosis and lung disease, but its effect on NAFLD is unknown. PM2.5 induces pulmonary dysfunction via Toll-like receptor (TLR) activation on alveolar macrophages. TLR activation of Kupffer cells, resident hepatic macrophages, and subsequent pro-inflammatory cytokine production have been shown to play a key role in NAFLD progression. We hypothesized that PM2.5 exposure is a significant risk factor for the progression of NAFLD. Thus, following exposure of male C57BL/6 mice fed high fat chow (HFC) to concentrated air particulate matter (CAPs) or filtered air for 6 weeks, progression of NAFLD was evaluated by standardized histological assessment of hepatic inflammation and fibrosis. In mice fed HFC, the hepatic inflammatory grade (3.00 +/- 0.00 vs. 1.50 +/- 0.71, P < 0.001) and fibrosis stage (1.00 +/- 0.00 vs. 0.60 +/- 0.52, P = 0.023) were both significantly higher in mice exposed to CAPs versus filtered air, respectively. Increased numbers of Kupffer cells contained PM in CAPs-exposed mice scores of (2.00 +/- 0.94 vs. 0.20 +/- 0.42, respectively, P < 0.001). PM exposure increased IL-6 secretion up to sevenfold in a dose-dependent manner by isolated wild-type but not TLR4(-/-) Kupffer cells (P < 0.050). In conclusion, ambient PM2.5 exposure may be a significant risk factor for NAFLD progression.
C1 [Tan, Hui-Hui; Guo, Jinsheng; Friedman, Scott L.; Odin, Joseph A.; Allina, Jorge] Mt Sinai Sch Med, Dept Med, New York, NY USA.
   [Fiel, M. Isabel; Gordon, Ronald E.] Mt Sinai Sch Med, Dept Pathol, New York, NY USA.
   [Sun, Qinghua] Ohio State Univ, Coll Publ Hlth, Div Environm Hlth Sci, Columbus, OH 43210 USA.
   [Chen, Lung-Chi; Odin, Joseph A.; Allina, Jorge] NYU, Sch Med, Dept Environm Med, Tuxedo Pk, NY USA.
   [Tan, Hui-Hui] Singapore Gen Hosp, Dept Gastroenterol & Hepatol, Singapore 0316, Singapore.
   [Guo, Jinsheng] Fudan Univ, Zhongshan Hosp, Div Digest Dis, Shanghai 200433, Peoples R China.
C3 Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at
   Mount Sinai; University System of Ohio; Ohio State University; New York
   University; Singapore General Hospital; Fudan University
RP Odin, JA (corresponding author), 1 Gustave L Levy Pl,Box 1101, New York, NY 10029 USA.
EM Joseph.Odin@msnyuhealth.org
RI Sun, Qinghua/E-4167-2011; Friedman, Scott/AFV-6304-2022
OI Fiel, Maria Isabel/0000-0002-7314-6313; Chen, Lung
   Chi/0000-0003-1154-2107; guo, Jinsheng/0000-0002-9980-8725
FU NIH [KO1ES016588]
FX C. E. Alvarez' technical support for mRNA analysis and Kupffer cell
   isolation were invaluable. C. E. Jackson's helpful review and
   suggestions during manuscript preparation are much appreciated. Qinghua
   Sun is supported by NIH KO1ES016588
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NR 49
TC 104
Z9 111
U1 4
U2 40
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1547-691X
EI 1547-6901
J9 J IMMUNOTOXICOL
JI J. Immunotoxicol.
PY 2009
VL 6
IS 4
BP 266
EP 275
DI 10.3109/15476910903241704
PG 10
WC Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Toxicology
GA 561TJ
UT WOS:000275001500009
PM 19908945
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Sánchez-Patán, F
   Anchuelo, R
   Aller, MA
   Vara, E
   García, C
   Nava, MP
   Arias, J
AF Sanchez-Patan, Fernando
   Anchuelo, Raquel
   Aller, Maria-Angeles
   Vara, Elena
   Garcia, Cruz
   Nava, Maria-Paz
   Arias, Jaime
TI Chronic prehepatic portal hypertension in the rat:: is it a type of
   Metabolic Inflammatory Syndrome?
SO LIPIDS IN HEALTH AND DISEASE
LA English
DT Article
ID FATTY LIVER-DISEASE; LIPID-METABOLISM; INSULIN-RESISTANCE; OXIDATIVE
   STRESS; BINDING-PROTEIN; ANGIOTENSIN-II; NITRIC-OXIDE; SHORT-TERM;
   CHOLESTEROL; MEDIATORS
AB Background: A progressive development of hepatic steatosis with an increase in the lipid hepatocyte content and the formation of megamitochondria have been demonstrated in rats with prehepatic portal hypertension. The aim of this study is to verify the existence of liver and serum lipid metabolism impairments in rats with long-term ( 2 years) portal hypertension.
   Methods: Male Wistar rats: Control (n = 10) and with prehepatic portal hypertension by triple partial portal vein ligation ( n = 9) were used. Liver content of Triglycerides (TG), phospholipids (PL) and cholesterol and serum cholesterol, lipoproteins (HDL and LDL), TG, glucose and Lipid Binding Protein (LBP) were assayed with specific colorimetric commercial kits. Serum levels of insulin and somatostatin were assayed by RIA.
   Results: The liver content of TG (6.30 +/- 1.95 vs. 4.17 +/- 0.59 mu g/ml; p < 0.01) and cholesterol (1.48 +/- 0.15 vs. 1.10 +/- 0.13 mu g/ml; p < 0.001) increased in rats with portal hypertension. The serum levels of cholesterol (97.00 + 26.02 vs. 114.78 +/- 37.72 mg/dl), TG (153.41 +/- 80.39 vs. 324.39 +/- 134.9 mg/dl; p < 0.01), HDL ( 20.45 +/- 5.14 vs. 55.15 +/- 17.47 mg/dl; p < 0.001) and somatostatin (1.32 +/- 0.31 vs. 1.59 + 0.37 mg/dl) decreased, whereas LDL (37.83 +/- 15.39 vs. 16.77 +/- 6.81 mg/dl; p < 0.001) and LBP (308.47 +/- 194.53 vs. 60.27 +/- 42.96 ng/ml; p < 0.001) increased.
   Conclusion: Portal hypertension in the rat presents changes in the lipid and carbohydrate metabolisms similar to those produced in chronic inflammatory conditions and sepsis in humans. These underlying alterations could be involved in the development of hepatic steatosis and, therefore, in those described in the metabolic syndrome in humans.
C1 [Sanchez-Patan, Fernando; Anchuelo, Raquel; Aller, Maria-Angeles; Arias, Jaime] Univ Complutense Madrid, Dept Surg 1, Sch Med, E-28040 Madrid, Spain.
   [Vara, Elena; Garcia, Cruz] Univ Complutense Madrid, Biochem & Mol Biol Dept 3, Sch Med, E-28040 Madrid, Spain.
   [Nava, Maria-Paz] Univ Complutense Madrid, Dept Physiol Anim Physiol 2, Sch Biol, E-28040 Madrid, Spain.
C3 Complutense University of Madrid; Complutense University of Madrid;
   Complutense University of Madrid
RP Aller, MA (corresponding author), Univ Complutense Madrid, Dept Surg 1, Sch Med, E-28040 Madrid, Spain.
EM fspatan@hotmail.com; rakivet@hotmail.com; maaller@med.ucm.es;
   evaraami@med.ucm.es; mcruzg@med.ucm.es; mpnava@bio.ucm.es;
   jariasp@med.ucm.es
RI Garcia, Cruz/GRF-6283-2022; Arias Perez, Jaime/L-2773-2017; Aller, Maria
   Angeles/L-2785-2017
OI Arias Perez, Jaime/0000-0003-0182-7790; Aller, Maria
   Angeles/0000-0002-9232-8446
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NR 54
TC 18
Z9 19
U1 0
U2 2
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1476-511X
J9 LIPIDS HEALTH DIS
JI Lipids Health Dis.
PD FEB 13
PY 2008
VL 7
AR 4
DI 10.1186/1476-511X-7-4
PG 10
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA 278UK
UT WOS:000254311600001
PM 18271959
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Mishra, K
   Kakhlon, O
AF Mishra, Kumudesh
   Kakhlon, Or
TI The Crucial Role of NAD plus in Mitochondrial Metabolic Regulation
SO BIOCELL
LA English
DT Review; Early Access
DE Nicotinamide adenine dinucleotide; mitochondria; mitochondrial
   dysfunction; metabolic syndrome; glycogen storage disorders
ID CYCLIC-ADP-RIBOSE; PERMEABILITY TRANSITION PORE; HIGH-FAT DIET;
   OXIDATIVE STRESS; POLY(ADP-RIBOSE) POLYMERASES;
   HEPATOCELLULAR-CARCINOMA; CALORIC RESTRICTION; ENERGY HOMEOSTASIS;
   NAD(+)/NADH RATIO; PROTEIN-KINASE
AB Mitochondria are central organelles in cellular metabolism, orchestrating energy production, biosynthetic pathways, and signaling networks. Nicotinamide adenine dinucleotide (NAD+) and its reduced form (NADH) are essential for mitochondrial metabolism, functioning both as redox coenzymes and as signaling agents that help regulate cellular balance. Thus, while its major role is in energy production, NAD+ is widely recognized as a metabolic cofactor and also serves as a substrate for various enzymes involved in cellular signaling, like sirtuins (SIRTs), poly (ADP-ribosyl) polymerases (PARPs), mono (ADP-ribosyl) transferases, and CD38. Sirtuins, a family of NAD+dependent deacetylases, are critical in this regulatory network. SIRT3 removes acetyl groups from and enhances the activity of key enzymes that participate in fatty acid breakdown, the tricarboxylic acid (TCA) cycle, and the electron transport chain (etc), thereby enhancing mitochondrial efficiency and energy production. Mitochondrial NAD+ biosynthesis involves multiple pathways, including the de novo synthesis from tryptophan via the kynurenine and the salvage pathway, which recycles nicotinamide back to NAD+. Moreover, NAD+ concentrations influence mitochondrial dynamics such as fusion, fission, and mitophagy, which are essential for preserving mitochondrial integrity and function. NAD+ also modulates the balance between glycolysis and oxidative phosphorylation, influencing the metabolic flexibility of cells. During NAD+ depletion, mainly in metabolic disorders, cells often shift towards anaerobic glycolysis, reducing ATP production efficiency and increasing lactate production. This metabolic shift is associated with various pathophysiological conditions, including insulin resistance, neurodegeneration, and muscle wasting. This review explores the multifaceted functions of NAD+ in regulating mitochondrial metabolism. It highlights the underlying causes and pathological outcomes of disrupted NAD+ metabolism while exploring potential therapeutic targets and treatment strategies.
C1 [Mishra, Kumudesh; Kakhlon, Or] Hadassah Hebrew Univ, Med Ctr, Agnes Ginges Ctr Human Neurogenet, Dept Neurol, IL-9112001 Jerusalem, Israel.
   [Mishra, Kumudesh; Kakhlon, Or] Hebrew Univ Jerusalem, Fac Med, IL-9112102 Jerusalem, Israel.
C3 Hebrew University of Jerusalem
RP Mishra, K (corresponding author), Hadassah Hebrew Univ, Med Ctr, Agnes Ginges Ctr Human Neurogenet, Dept Neurol, IL-9112001 Jerusalem, Israel.; Mishra, K (corresponding author), Hebrew Univ Jerusalem, Fac Med, IL-9112102 Jerusalem, Israel.
EM kumudeshmishra@gmail.com
RI Kajimura, Shingo/AAC-5090-2019
FU Golda Meir Fellowship Fund, The Hebrew University of Jerusalem, Israel
FX A fellowship support from the Golda Meir Fellowship Fund, The Hebrew
   University of Jerusalem, Israel.
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NR 175
TC 0
Z9 0
U1 0
U2 0
PU TECH SCIENCE PRESS
PI HENDERSON
PA 871 CORONADO CENTER DR, SUTE 200, HENDERSON, NV 89052 USA
SN 0327-9545
EI 1667-5746
J9 BIOCELL
JI Biocell
PD 2025 MAY 7
PY 2025
DI 10.32604/biocell.2025.061725
EA MAY 2025
PG 23
WC Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics
GA 2SC1T
UT WOS:001489976100001
DA 2025-06-11
ER

PT J
AU Rahawi, AH
   He, F
   Fang, JD
   Calhoun, SL
   Vgontzas, AN
   Liao, DP
   Bixler, EO
   Younes, M
   Ricci, A
   Fernandez-Mendoza, J
AF Rahawi, Anthony H.
   He, Fan
   Fang, Jidong
   Calhoun, Susan L.
   Vgontzas, Alexandros N.
   Liao, Duanping
   Bixler, Edward O.
   Younes, Magdy
   Ricci, Anna
   Fernandez-Mendoza, Julio
TI Association of novel EEG biomarkers of sleep depth and cortical
   arousability with cardiac autonomic modulation in adolescents
SO SLEEP
LA English
DT Article; Early Access
DE heart rate variability; EEG analysis; development; odds ratio product;
   ORP; ORP-9; NREM; sleep depth; cortical arousability
ID HEART-RATE-VARIABILITY; EXCESSIVE DAYTIME SLEEPINESS; ODDS RATIO
   PRODUCT; METABOLIC SYNDROME BURDEN; SLOW-WAVE ACTIVITY; SYSTEMIC
   INFLAMMATION; RISK-FACTORS; CHILDREN; STRESS; POPULATION
AB Study Objectives To examine the developmental association of the odds ratio product (ORP), an electroencephalographic measure of sleep depth, during non-rapid eye movement (NREM) sleep with 24-hour heart rate variability (HRV), an electrocardiographic measure of cardiac autonomic modulation (CAM), in the transition to adolescence. Methods Leveraging data from the Penn State Child Cohort, we performed longitudinal analyses on 313 children (median [Md] age 9 years) followed-up after Md = 7.4y and cross-sectional analyses on 344 adolescents (Md = 16 years). We extracted ORP during NREM sleep and in the 9 seconds following cortical arousals (ORP-9) from 9-hour, in-lab polysomnography, and frequency- and time-domain HRV indices from 24-hour Holter ECG monitoring. Longitudinal and cross-sectional, multivariable-adjusted, regression models examined the association between ORP and ORP-9 with adolescent 24-hour HRV indices. Results Longitudinally, a greater increase in ORP-9 since childhood was associated with lower daytime Log-LF, SDNN, RMSSD, and higher HR in adolescence (p < .05). A greater increase in ORP since childhood was associated with lower nighttime Log-LF and SDNN (p < .05). Cross-sectionally, higher ORP and ORP-9 were associated with lower daytime and nighttime Log-LF, SDNN or RMSSD and higher HR within adolescence (p < .05). Conclusions A greater increase in cortical arousability since childhood is a strong developmental predictor of daytime cardiac autonomic imbalance in adolescence. Shallower sleep depth additionally arises as a proximal determinant of both daytime and nighttime cardiac autonomic imbalance within adolescence. These data suggest a coupling between fine-grained spectral measures of the sleeping brain and those of CAM, which may inform sleep-related cardiovascular risk early in life.
C1 [Rahawi, Anthony H.; Fang, Jidong; Calhoun, Susan L.; Vgontzas, Alexandros N.; Bixler, Edward O.; Fernandez-Mendoza, Julio] Penn State Coll Med, Sleep Res & Treatment Ctr, Dept Psychiat & Behav Hlth, 50 Univ Dr,H073, Hershey, PA 17033 USA.
   [He, Fan; Liao, Duanping] Penn State Coll Med, Dept Publ Hlth Sci, Hershey, PA USA.
   [Younes, Magdy] Univ Manitoba, Sleep Disorders Ctr, Dept Med, Winnipeg, MB, Canada.
   [Ricci, Anna] Univ Vermont, Larner Coll Med, Dept Neurol Sci, Burlington, VT USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE);
   Pennsylvania State University; Penn State Health; Pennsylvania
   Commonwealth System of Higher Education (PCSHE); Pennsylvania State
   University; Penn State Health; University of Manitoba; University of
   Vermont
RP Fernandez-Mendoza, J (corresponding author), Penn State Coll Med, Sleep Res & Treatment Ctr, Dept Psychiat & Behav Hlth, 50 Univ Dr,H073, Hershey, PA 17033 USA.
EM jfmendoza@psu.edu
RI Rahawi, Anthony/KDN-0683-2024; Fernandez-Mendoza, Julio/AAH-8128-2021
OI Fernandez-Mendoza, Julio/0000-0001-9584-6161; Rahawi,
   Anthony/0000-0003-4372-7691
FU National Institute of Mental Health; National Heart, Lung, and Blood
   Institute; National Center for Advancing Translational Sciences of the
   National Institutes of Health [R01MH118308, R01HL136587, UL1TR002014]
FX This work was supported by the National Institute of Mental Health, the
   National Heart, Lung, and Blood Institute, and the National Center for
   Advancing Translational Sciences of the National Institutes of Health
   under Awards Number R01MH118308 (Fernandez-Mendoza), R01HL136587
   (Fernandez-Mendoza), and UL1TR002014 (Kraschnewski). The content is
   solely the responsi-bility of the authors and does not necessarily
   represent the offi-cial views of the National Institutes of Health.
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NR 90
TC 0
Z9 0
U1 0
U2 0
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0161-8105
EI 1550-9109
J9 SLEEP
JI Sleep
PD 2025 FEB 17
PY 2025
DI 10.1093/sleep/zsaf018
EA FEB 2025
PG 16
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA X2D0B
UT WOS:001423507000001
PM 39887059
DA 2025-06-11
ER

PT J
AU Restaino, RM
   Barlow, MA
AF Restaino, Robert M.
   Barlow, Matthew A.
TI Limb-Specific Comparison of Flow-Mediated Dilation in Abdominal Obese
   Pre-menopausal Women
SO ARTERY RESEARCH
LA English
DT Article
DE Abdominal obese; Women; Flow-mediated dilation; Limb differences
ID ENDOTHELIAL DYSFUNCTION; REACTIVE HYPEREMIA; METABOLIC SYNDROME;
   OXIDATIVE STRESS; BLOOD-FLOW; EXERCISE; IMPACT; TIME; SEX; RESISTANCE
AB PurposeNormal aging can lead to arterial wall stiffening and development of atherosclerosis; however, the effects of overweight conditions can expedite the dysfunction of arterial health. In an earlier study, we identified in a group of abdominal obese pre-menopausal woman that during menses, these women had decreased vascular conductance of the brachial artery during dynamic hand-grip exercise. Endothelial function in abdominal obese (AO) premenopausal women could be associated with being highly sedentary which attenuates dilatory responses to FMD of both upper and lower limb vascular function. We hypothesized that the AO women would exhibit limb-specific differences in artery dilation with reduced dilation in the popliteal artery as compared to the brachial artery. MethodsArtery dilatory responses in the brachial and popliteal arteries were assessed using flow-mediated dilation (FMD) in age-matched sedentary controls and AO groups during menses. ResultsSignificant differences were found between groups including % BF, BMI, weight, waist to hip ratio, fasting blood glucose, and oxLDL. A between-group comparison revealed significantly lower percent dilation of the popliteal artery in AO participants compared to controls (p < 0.05) not present in the brachial arteries. Our results also indicate a difference in the time-to-peak (TP) of dilation between the control (33.38 +/- 3.232) and AO (62.104 +/- 5.813) groups (p < 0.01). Following FMD correction with shear rate as the covariate, significant differences in FMD between the brachial and popliteal artery were abolished. ConclusionWe conclude that young, AO women show a limb-specific difference in dilation of the upper and lower extremities when compared to controls. Thus, reductions in FMD of the popliteal artery could be due to impaired dilation of the downstream resistance vasculature preventing increases in shear within the leg conduit arteries not as significantly in the arms.
C1 [Barlow, Matthew A.] Eastern New Mexico Univ, Dept Biol, 1500 S Ave K Stn 33, Portales, NM 88130 USA.
   [Restaino, Robert M.] Trocaire Coll, Biol Div, Buffalo, NY 14220 USA.
C3 Eastern New Mexico University
RP Barlow, MA (corresponding author), Eastern New Mexico Univ, Dept Biol, 1500 S Ave K Stn 33, Portales, NM 88130 USA.
EM matthew.barlow@enmu.edu
FU National Institute of General Medical Sciences of the National
   Institutes of Health [P20GM103451]
FX Research reported in this publication was supported by an Institutional
   Development Award (IDeA) from the National Institute of General Medical
   Sciences of the National Institutes of Health under grant number
   P20GM103451.
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NR 35
TC 0
Z9 0
U1 0
U2 1
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1872-9312
EI 1876-4401
J9 ARTERY RES
JI Artery Res.
PD NOV 18
PY 2024
VL 30
IS 1
AR 20
DI 10.1007/s44200-024-00065-5
PG 9
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA M6T1N
UT WOS:001358830500001
OA gold
DA 2025-06-11
ER

PT J
AU Zhao, S
   Zhou, L
   Wang, Q
   Cao, JH
   Chen, Y
   Wang, W
   Zhu, BD
   Wei, ZH
   Li, R
   Li, CY
   Zhou, GY
   Tan, ZJ
   Zhou, HP
   Li, CX
   Gao, HK
   Qin, XJ
   Lian, K
AF Zhao, Shuai
   Zhou, Lei
   Wang, Qin
   Cao, Jia-Hao
   Chen, Yan
   Wang, Wei
   Zhu, Bo-Da
   Wei, Zhi-Hong
   Li, Rong
   Li, Cong-Ye
   Zhou, Geng-Yao
   Tan, Zhi-Jun
   Zhou, He-Ping
   Li, Cheng-Xiang
   Gao, Hao-Kao
   Qin, Xu-Jun
   Lian, Kun
TI Elevated branched-chain amino acid promotes atherosclerosis progression
   by enhancing mitochondrial-to-nuclear H2O2-disulfide HMGB1 in
   macrophages
SO REDOX BIOLOGY
LA English
DT Article
DE Atherosclerosis (AS); Branched-chain amino acid (BCAA); Macrophage;
   Inflammation; Mitochondria; HMGB1
ID ALPHA-KETO ACIDS; OXIDATIVE STRESS; INFLAMMATION; METABOLISM;
   CATABOLISM; PHENOTYPE; RECEPTOR; PATHWAY; DISEASE; CELLS
AB As the essential amino acids, branched-chain amino acid (BCAA) from diets is indispensable for health. BCAA supplementation is often recommended for patients with consumptive diseases or healthy people who exercise regularly. Latest studies and ours reported that elevated BCAA level was positively correlated with metabolic syndrome, diabetes, thrombosis and heart failure. However, the adverse effect of BCAA in atherosclerosis (AS) and its underlying mechanism remain unknown. Here, we found elevated plasma BCAA level was an independent risk factor for CHD patients by a human cohort study. By employing the HCD-fed ApoE-/- mice of AS model, ingestion of BCAA significantly increased plaque volume, instability and inflammation in AS. Elevated BCAA due to high dietary BCAA intake or BCAA catabolic defects promoted AS progression. Furthermore, BCAA catabolic defects were found in the monocytes of patients with CHD and abdominal macrophages in AS mice. Improvement of BCAA catabolism in macrophages alleviated AS burden in mice. The protein screening assay revealed HMGB1 as a potential molecular target of BCAA in activating proinflammatory macrophages. Excessive BCAA induced the formation and secretion of disulfide HMGB1 as well as subsequent inflammatory cascade of macrophages in a mitochondrial-nuclear H2O2 dependent manner. Scavenging nuclear H2O2 by overexpression of nucleustargeting catalase (nCAT) effectively inhibited BCAA-induced inflammation in macrophages. All of the results above illustrate that elevated BCAA promotes AS progression by inducing redox-regulated HMGB1 translocation and further proinflammatory macrophage activation. Our findings provide novel insights into the role of animo acids as the daily dietary nutrients in AS development, and also suggest that restricting excessive dietary BCAA consuming and promoting BCAA catabolism may serve as promising strategies to alleviate and prevent AS and its subsequent CHD.
C1 [Zhao, Shuai; Wei, Zhi-Hong; Li, Cong-Ye; Li, Cheng-Xiang; Gao, Hao-Kao; Lian, Kun] Fourth Mil Med Univ, Xijing Hosp, Dept Cardiol, Xian 710032, Shaanxi, Peoples R China.
   [Zhou, Lei; Wang, Wei] Fourth Mil Med Univ, Xijing Hosp, Dept Clin Lab Med, Xian 710032, Shaanxi, Peoples R China.
   [Wang, Qin] Fourth Mil Med Univ, Dept Pharmacogen, Xian 710032, Shaanxi, Peoples R China.
   [Cao, Jia-Hao] Shaanxi Univ Chinese Med, Sch Publ Hlth, Xianyang 712046, Shaanxi, Peoples R China.
   [Chen, Yan] 971 Hosp PLA Navy, Dept Cardiol, Qingdao 266071, Shandong, Peoples R China.
   [Zhu, Bo-Da] Air Force Aviat Univ, Primary Flight Training Base, Harbin 150100, Heilongjiang, Peoples R China.
   [Li, Rong] Fourth Mil Med Univ, Xijing Hosp, Dept Geriatr, Xian 710032, Shaanxi, Peoples R China.
   [Zhou, Geng-Yao] Fourth Mil Med Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Xian 710032, Shaanxi, Peoples R China.
   [Tan, Zhi-Jun] Fourth Mil Med Univ, Sch Publ Hlth, Dept Hlth Stat, Minist Educ,Key Lab Hazard Assessment & Control S, Xian 710032, Shaanxi, Peoples R China.
   [Zhou, He-Ping] Xi An Jiao Tong Univ, Dept Cardiovasc Surg, Affiliated Hosp 1, Xian 710061, Shaanxi, Peoples R China.
   [Qin, Xu-Jun] Northwestern Polytech Univ, Sch Life Sci, Key Lab Space Biosci & Biotechnol, Xian 710072, Shaanxi, Peoples R China.
C3 Air Force Medical University; Air Force Medical University; Air Force
   Medical University; Shaanxi University of Chinese Medicine; Air Force
   Medical University; Air Force Medical University; Ministry of Education
   - China; Air Force Medical University; Xi'an Jiaotong University;
   Northwestern Polytechnical University
RP Gao, HK; Lian, K (corresponding author), Forth Mil Med Univ, Xijing Hosp, Dept Cardiol, 127 West Changle Rd, Xian 710032, Shaanxi, Peoples R China.; Qin, XJ (corresponding author), Northwestern Polytech Univ, Sch Life Sci, Key Lab Space Biosci & Biotechnol, 127 West Youyi Rd, Xian 710072, Shaanxi, Peoples R China.
EM hk_gao@163.com; qinxujun@nwpu.edu.cn; liank1122@163.com
RI Wei, ZhiHong/KPA-7622-2024
FU National Natural Science Foundation of China [81670229, 81702733];
   "Advanced Foundation" of Xinxin Cardiovascular Health Foundation in
   Suzhou Industrial Park, China [2019-CCAACCESS065]; Xi'an Science and
   Technology Project, China [20YXYJ0003 (4)]; Bethune-Merck Diabetes
   Research Foundation, China [G2017044]; New Clinical Technology and New
   Business of Xijing Hospital, China [XJGX15Y39]
FX This study was supported by the National Natural Science Foundation of
   China (81670229, 81702733); "Advanced Foundation" of Xinxin
   Cardiovascular Health Foundation in Suzhou Industrial Park, China
   (2019-CCAACCESS065); Xi'an Science and Technology Project, China
   (20YXYJ0003(4)); Bethune-Merck Diabetes Research Foundation, China
   (G2017044); New Clinical Technology and New Business of Xijing Hospital,
   China (XJGX15Y39).
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NR 51
TC 26
Z9 26
U1 5
U2 28
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2213-2317
J9 REDOX BIOL
JI Redox Biol.
PD JUN
PY 2023
VL 62
AR 102696
DI 10.1016/j.redox.2023.102696
EA APR 2023
PG 17
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA F8HI3
UT WOS:000984699700001
PM 37058999
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Koeder, C
   Anand, C
   Husain, S
   Kranz, RM
   Schoch, N
   Alzughayyar, D
   Bitterlich, N
   Hahn, A
   Englert, H
AF Koeder, Christian
   Anand, Corinna
   Husain, Sarah
   Kranz, Ragna-Marie
   Schoch, Nora
   Alzughayyar, Dima
   Bitterlich, Norman
   Hahn, Andreas
   Englert, Heike
TI Exploratory analysis of the effect of a controlled lifestyle
   intervention on inflammatory markers - the Healthy Lifestyle Community
   Programme (cohort 2)
SO BMC NUTRITION
LA English
DT Article
DE Plant-based diet; Subclinical inflammation; C-reactive protein;
   Homocysteine; Adiponectin; Cardiovascular disease; Lifestyle
   intervention
ID PLANT-BASED DIETS; METABOLIC SYNDROME; ADIPONECTIN; RISK; HOMOCYSTEINE;
   MORTALITY; METAANALYSIS; ASSOCIATION; CONSUMPTION; GENISTEIN
AB Background Chronic low-grade inflammation is associated with an increased risk of chronic disease and mortality. The objective of the study was to test the effect of a healthy lifestyle intervention on biomarkers of inflammation (among other risk markers).Methods We conducted a non-randomized controlled trial with mostly middle-aged and elderly participants from the general population in rural northwest Germany (intervention: n = 114; control: n = 87). The intervention consisted of a 1-year lifestyle programme focusing on diet (largely plant-based; strongest emphasis), physical activity, stress management, and social support. High-sensitivity C-reactive protein (hs-CRP) was assessed at baseline, 10 weeks, 6 months, and 1 year. Homocysteine (Hcy) was assessed at baseline, 10 weeks, and 1 year. Adiponectin (Apn) was assessed at baseline and 10 weeks. An exploratory analysis of these inflammatory markers assessing the between-group differences with ANCOVA was conducted.Results The 1-year trajectory of hs-CRP was significantly lower in the intervention group compared to control (between-group difference: -0.8 (95% CI -1.2, -0.3) mg/l; p = 0.001; adjusted for baseline). The 1-year trajectory of Hcy was non-significantly higher in the intervention compared to control (between-group difference: 0.2 (95% CI -0.3, 0.7) mu mol/l; p = 0.439; adjusted for baseline). From baseline to 10 weeks, Apn decreased significantly more in the intervention group compared to control (between-group difference: -1.6 (95% CI -2.7, -0.5) mu g/ml; p = 0.004; adjusted for baseline).Conclusions Our study shows that healthy lifestyle changes can lower hs-CRP and Apn levels and are unlikely to significantly affect Hcy levels within 1 year.
C1 [Koeder, Christian; Hahn, Andreas] Leibniz Univ Hannover, Inst Food Sci & Human Nutr, Hannover, Germany.
   [Koeder, Christian; Anand, Corinna; Husain, Sarah; Kranz, Ragna-Marie; Schoch, Nora; Alzughayyar, Dima; Englert, Heike] Univ Appl Sci Munster, Dept Nutr, Munster, Germany.
   [Bitterlich, Norman] Med & Serv GmbH, Dept Biostat, Chemnitz, Germany.
C3 Leibniz University Hannover; University of Applied Sciences, Muenster
RP Koeder, C (corresponding author), Leibniz Univ Hannover, Inst Food Sci & Human Nutr, Hannover, Germany.; Koeder, C (corresponding author), Univ Appl Sci Munster, Dept Nutr, Munster, Germany.
EM koeder@fh-muenster.de
RI Koeder, Christian/JEP-7424-2023; Husain, Sarah/NBX-6933-2025; Hahn,
   Andreas/HJA-8368-2022
OI Koeder, Christian/0000-0002-3761-4220; Nasereddin/ Alzughayyar,
   Dima-Karam/0009-0005-6151-2848; Weber, Ragna-Marie/0000-0002-7191-9888;
   Hahn, Andreas/0000-0001-8459-6582
FU Projekt DEAL; German Federal Ministry of Education and Research (BMBF);
   Joint Science Conference (GWK) within the programme "Innovative
   Hochschule" [03IHS062A]
FX Open Access funding enabled and organized by Projekt DEAL. This work was
   conducted as part of the project "muenster.land.leben"and was funded by
   the German Federal Ministry of Education and Research (BMBF) and the
   Joint Science Conference (GWK) within the programme "Innovative
   Hochschule" (grant number: 03IHS062A).The funders had no role in the
   study design, data collection, analysis, or interpretation, writing of
   the report, or the decision to publish the findings.
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NR 60
TC 4
Z9 4
U1 0
U2 1
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 2055-0928
J9 BMC NUTR
JI BMC Nutr.
PD FEB 6
PY 2023
VL 9
IS 1
AR 25
DI 10.1186/s40795-023-00684-2
PG 14
WC Nutrition & Dietetics
WE Emerging Sources Citation Index (ESCI)
SC Nutrition & Dietetics
GA 8R7JE
UT WOS:000928066100002
PM 36747285
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Chiavaroli, A
   di Giacomo, V
   De Filippis, B
   Cataldi, A
   Ferrante, C
   Giampietro, L
AF Chiavaroli, Annalisa
   di Giacomo, Viviana
   De Filippis, Barbara
   Cataldi, Amelia
   Ferrante, Claudio
   Giampietro, Letizia
TI The Small Molecule PPARγ Agonist GL516 Induces Feeding-Stimulatory
   Effects in Hypothalamus Cells Hypo-E22 and Isolated Hypothalami
SO MOLECULES
LA English
DT Article
DE PPAR gamma agonists; fibrates; neuroprotection; hypothalamus; small
   molecules; neuropeptides; neurotransmitters
ID ACTIVATED RECEPTOR-GAMMA; BRAIN; ANALOGS
AB PPAR gamma agonists are implicated in the regulation of diabetes and metabolic syndrome and have therapeutic potential in brain disorders. PPAR gamma modulates appetite through its central effects, especially on the hypothalamic arcuate nucleus (ARC). Previous studies demonstrated that the small molecule GL516 is a PPAR gamma agonist able to reduce oxidative stress and apoptosis with a potential neuroprotective role. Herein, we investigated the effects of GL516, in vitro and ex vivo, on the levels of hypothalamic dopamine (DA) and serotonin (5-HT). The gene expressions of neuropeptide Y, CART, AgRP, and POMC, which play master roles in the neuroendocrine regulation of feeding behavior and energy balance, were also evaluated. HypoE22 cells were treated with H2O2 (300 mu M) for 2 h e 30' and with different concentrations of GL516 (1 nM-100 p.M). The cell viability was evaluated after 24 and 48 h of culturing using the MTT test. DA and 5-HT levels in the HypoE22 cell supernatants were analyzed through HPLC; an ex vivo study on isolated hypothalamic specimens challenged with scalar concentrations of GL516 (1-100 mu M) and with pioglitazone (10 mu M) was carried out. The gene expressions of CART, NPY, AgRP, and POMC were also determined by a quantitative real-time PCR. The results obtained showed that GL516 was able to reduce DA and 5-HT turnover; moreover, it was effective in stimulating NPY and AgRP gene expressions with a concomitant reduction in CART and POMC gene expressions. These results highlight the capability of GL516 to modulate neuropeptide pathways deeply involved in appetite control suggesting an orexigenic effect. These findings emphasize the potential use of GL516 as a promising candidate for therapeutical applications in neurodegenerative diseases associated with the reduction in food intake and stimulation of catabolic pathways.
C1 [Chiavaroli, Annalisa; di Giacomo, Viviana; De Filippis, Barbara; Cataldi, Amelia; Ferrante, Claudio; Giampietro, Letizia] Univ G dAnnunzio, Dept Pharm, Via Vestini 31, I-66100 Chieti, Italy.
C3 G d'Annunzio University of Chieti-Pescara
RP Giampietro, L (corresponding author), Univ G dAnnunzio, Dept Pharm, Via Vestini 31, I-66100 Chieti, Italy.
EM annalisa.chiavaroli@unich.it; viviana.digiacomo@unich.it;
   barbara.defilippis@unich.it; amelia.cataldi@unich.it;
   claudio.ferrante@unich.it; letizia.giampietro@unich.it
RI Giampietro, Letizia/N-5848-2014; Ferrante, Claudio/AEY-9584-2022
FU FAR funds (Italian Ministry for Instruction, University and Research)
FX This work was supported by FAR funds (Italian Ministry for Instruction,
   University and Research) assigned to Letizia Giampietro, Viviana di
   Giacomo, and Annalisa Chiavaroli.
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NR 40
TC 0
Z9 0
U1 1
U2 2
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 1420-3049
J9 MOLECULES
JI Molecules
PD AUG
PY 2022
VL 27
IS 15
AR 4882
DI 10.3390/molecules27154882
PG 10
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 3S6YX
UT WOS:000839740800001
PM 35956831
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Rizzetti, DA
   Corrales, P
   Uranga-Ocio, JA
   Medina-Gómez, G
   Peçanha, FM
   Vassallo, DV
   Miguel, M
   Wiggers, GA
AF Rizzetti, Danize Aparecida
   Corrales, Patricia
   Antonio Uranga-Ocio, Jose
   Medina-Gomez, Gema
   Pecanha, Franck Maciel
   Vassallo, Dalton Valentim
   Miguel, Marta
   Wiggers, Giulia Alessandra
TI Potential benefits of egg white hydrolysate in the prevention of
   Hg-induced dysfunction in adipose tissue
SO FOOD & FUNCTION
LA English
DT Article
ID LONG-TERM INTAKE; INSULIN-RESISTANCE; METABOLIC SYNDROME; OXIDATIVE
   STRESS; CHRONIC EXPOSURE; MERCURY; APOPTOSIS; PROTEINS; GLUCOSE; PLASMA
AB Aim: To investigate the effects of egg white hydrolysate (EWH) on the lipid and glycemic metabolism disruption in the white adipose tissue (WAT) dysfunction induced by mercury (Hg). Experimental: Wistar rats were treated for 60 days: control (saline, intramuscular - i.m.); hydrolysate (EWH, gavage, 1 g kg(-1) day(-1)); mercury (HgCl2, i.m., 1(st) dose 4.6 mu g kg(-1), subsequent doses 0.07 mu g kg(-1) day(-1)) and hydrolysate-mercury (EWH-HgCl2). Hg level and histological analyses were performed in epididymal WAT (eWAT), pancreas and liver. GRP78, CHOP, PPAR alpha, PPAR gamma, leptin, adiponectin, and CD11 mRNA expressions were analyzed in eWAT. The plasma lipid profile, glucose, and insulin levels were measured. Antioxidant status was also evaluated in the plasma and liver. Results: EWH intake prevented the reduced eWAT weight, adipocyte size, insulin levels, and antioxidant defenses and the increased glucose and triglyceride levels induced by Hg exposure; hepatic glutathione levels were higher in rats co-treated with EWH. The increased mRNA expression of CHOP, PPAR alpha, and leptin induced by Hg was reduced in co-treated rats. EWH did not modify the elevated mRNA expression of GRP78, PPAR gamma and adiponectin in Hg-treated rats. Increased levels of Hg were found in the liver; the co-treatment did not alter this parameter. EWH prevented the morphological and metabolic disorder induced by Hg, by improving antioxidant defenses, inactivating pro-apoptotic pathways and normalizing the mRNA expression of PPARs and adipokines. Its effects enabled an increase in insulin levels and a normal balance between the fat storage and expenditure mechanisms in WAT. Conclusions: EWH may have potential benefits in the prevention and management of Hg-related metabolic disorders.
C1 [Rizzetti, Danize Aparecida; Pecanha, Franck Maciel; Wiggers, Giulia Alessandra] Univ Fed Pampa, Cardiovasc Physiol Lab, BR 472,KM 592, Uruguaiana, RS, Brazil.
   [Corrales, Patricia; Antonio Uranga-Ocio, Jose; Medina-Gomez, Gema] Univ Rey Juan Carlos, Dept Basic Hlth Sci, Atenas S-N, Alcorcon, Spain.
   [Antonio Uranga-Ocio, Jose] Univ Rey Juan Carlos, High Performance Res Grp Physiopathol & Pharmacol, Atenas S-N, Alcorcon, Spain.
   [Vassallo, Dalton Valentim] Univ Fed Espirito Santo, Cardiac Electromech & Vasc React Lab, Marechal Campos 1468, Vitoria, ES, Brazil.
   [Miguel, Marta] Inst Invest Ciencias Alimentac, Bioact & Food Anal Lab, Nicolas Cabrera 9,Campus Univ Cantoblanco, Madrid, Spain.
   [Rizzetti, Danize Aparecida] Univ Fed Santa Maria, Polytech Sch, Av Roraima 1000, Santa Maria, RS, Brazil.
C3 Universidade Federal do Pampa; Universidad Rey Juan Carlos; Universidad
   Rey Juan Carlos; Universidade Federal do Espirito Santo; Consejo
   Superior de Investigaciones Cientificas (CSIC); CSIC-UAM - Instituto de
   Investigacion en Ciencias de la Alimentacion (CIAL); Universidade
   Federal de Santa Maria (UFSM)
RP Rizzetti, DA; Wiggers, GA (corresponding author), Univ Fed Pampa, Cardiovasc Physiol Lab, BR 472,KM 592, Uruguaiana, RS, Brazil.
EM danize.rizzetti@gmail.com; patricia.corrales@urjc.es;
   jose.uranga@urjc.es; gema.medina@urjc.es; franckpecanha.72@gmail.com;
   daltonv2@outlook.com; marta.miguel@csic.es;
   giuliapecanha@unipampa.edu.br
RI Corrales, Patricia/U-4969-2019; Uranga, Jose/M-4343-2018; Medina-Gomez,
   Gema/F-5667-2016
OI Uranga, Jose/0000-0003-4656-8569; Medina-Gomez, Gema/0000-0001-8169-681X
FU Conselho Nacional de Desenvolvimento Cientifico e Tecnologico - CNPq
   [203440/2014-5, 44181/2014-9, 307399/2017-6]; Fundacao de Amparo a
   Pesquisa do Rio Grande do Sul - FAPERGS [PQG:19/2551-0001810-0];
   Fundacao de Amparo a Pesquisa e InovacAo do Espirito Santo - FAPES
   [80598773]; Agencia Estatal de Investigacion (AEI); Fondo Europeo de
   Desarrollo Regional (FEDER) [AGL2017-89213]
FX We thank Antonio Marquez, Raquel Franco and Julio Paredes from the
   Laboratory of Histology at the Universidad Rey Juan Carlos (URJC) for
   their technical assistance in tissue preparation. This work was
   supported by the Conselho Nacional de Desenvolvimento Cientifico e
   Tecnologico - CNPq [203440/2014-5; 44181/2014-9; 307399/2017-6];
   FundacAo de Amparo a Pesquisa do Rio Grande do Sul - FAPERGS
   [PQG:19/2551-0001810-0]; FundacAo de Amparo a Pesquisa e InovacAo do
   Espirito Santo - FAPES [No 80598773] and the Agencia Estatal de
   Investigacion (AEI) and Fondo Europeo de Desarrollo Regional (FEDER)
   [AGL2017-89213].
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NR 51
TC 3
Z9 3
U1 1
U2 5
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PD JUN 6
PY 2022
VL 13
IS 11
BP 5996
EP 6007
DI 10.1039/d2fo00561a
EA APR 2022
PG 12
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA 1W0HE
UT WOS:000795997700001
PM 35575219
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Ayer, A
   Fazakerley, DJ
   James, DE
   Stocker, R
AF Ayer, Anita
   Fazakerley, Daniel J.
   James, David E.
   Stocker, Roland
TI The role of mitochondrial reactive oxygen species in insulin resistance
SO FREE RADICAL BIOLOGY AND MEDICINE
LA English
DT Article
DE Insulin resistance; Mitochondria; Superoxide radical anion; Hydrogen
   peroxide; Coenzyme Q; Redox signaling
ID BROWN ADIPOSE-TISSUE; HIGH-FAT DIET; NICOTINAMIDE NUCLEOTIDE
   TRANSHYDROGENASE; RATIOMETRIC FLUORESCENT-PROBE; DIAGNOSTIC MARKER
   PRODUCTS; IMAGING HYDROGEN-PEROXIDE; CYTOCHROME-C; NITRIC-OXIDE;
   SUPEROXIDE-PRODUCTION; OXIDATIVE STRESS
AB Insulin resistance is one of the earliest pathological features of a suite of diseases including type 2 diabetes collectively referred to as metabolic syndrome. There is a growing body of evidence from both pre-clinical studies and human cohorts indicating that reactive oxygen species, such as the superoxide radical anion and hydrogen peroxide are key players in the development of insulin resistance. Here we review the evidence linking mitochondrial reactive oxygen species generated within mitochondria with insulin resistance in adipose tissue and skeletal muscle, two major insulin sensitive tissues. We outline the relevant mitochondria-derived reactive species, how the mitochondrial redox state is regulated, and methodologies available to measure mitochondrial reactive oxygen species. Importantly, we highlight key experimental issues to be considered when studying the role of mitochondrial reactive oxygen species in insulin resistance. Evaluating the available literature on both mitochondrial reactive oxygen species/redox state and insulin resistance in a variety of biological systems, we conclude that the weight of evidence suggests a likely role for mitochondrial reactive oxygen species in the etiology of insulin resistance in adipose tissue and skeletal muscle. However, major limitations in the methods used to study reactive oxygen species in insulin resistance as well as the lack of data linking mitochondrial reactive oxygen species and cytosolic insulin signaling pathways are significant obstacles in proving the mechanistic link between these two processes. We provide a framework to guide future studies to provide stronger mechanistic information on the link between mitochondrial reactive oxygen species and insulin resistance as understanding the source, localization, nature, and quantity of mitochondrial reactive oxygen species, their targets and downstream signaling pathways may pave the way for important new therapeutic strategies.
C1 [Ayer, Anita; Stocker, Roland] Univ Sydney, Heart Res Inst, Sydney, NSW, Australia.
   [Fazakerley, Daniel J.] Univ Cambridge, Wellcome Med Res Council, Metab Res Lab, Inst Metab Sci, Cambridge, England.
   [James, David E.] Univ Sydney, Charles Perkins Ctr, Sydney Med Sch, Sydney, NSW, Australia.
   [James, David E.; Stocker, Roland] Univ Sydney, Sch Life & Environm Sci, Sydney, NSW, Australia.
C3 University of Sydney; Heart Research Institute; University of Cambridge;
   University of Sydney; University of Sydney
RP Stocker, R (corresponding author), Heart Res Inst, 7 Eliza St, Newtown, Tas 2042, Australia.
EM roland.stocker@hri.org.au
RI Stocker, Roland/AAV-4489-2021; James, David/KYY-9051-2024; Fazakerley,
   Daniel/J-2652-2019
OI Fazakerley, Daniel/0000-0001-8241-2903; Ayer, Anita/0000-0002-7073-2835
FU Australian Research Council [DP15010408]; National Health and Medical
   Research Council of Australia [NHMRC1052616]; NHMRC Senior Principal
   Research Fellowship [1111632]; Medical Research Council Career
   Development Award [MR/S007091/1]; Australian Research Council Laureate
   Fellowship; National Health and Medical Research Council of Australia
   [1111632] Funding Source: NHMRC; MRC [MR/S007091/1] Funding Source: UKRI
FX This paper is dedicated to Professor Bruce Ames. RS wishes to express
   his deepest gratitude to Bruce for his unwavering support not only while
   RS carried out post-doctoral work in the Bruce Ames Lab in the 1980s but
   ever since then too. Bruce's curiosity, enthusiasm, and ability to
   distinguish between the important and less important scientific
   ques-tions while grappling with biological problems is unrivaled.
   This,together with his resilience and ongoing mentoring, has had a
   sustained and irreplaceable impact on RS career. Another enduring legacy
   Bruce taught and instilled in RS is the importance of developing new and
   improved methods to advance a field of research, a key aspect that is
   also highly relevant to the topic covered in the present paper. This
   research was supported by grants to RS from the Australian Research
   Council (DP15010408) and the National Health and Medical Research
   Council of Australia (NHMRC1052616) . RS was also supported by NHMRC
   Senior Principal Research Fellowship (1111632) . DJF was supported by a
   Medical Research Council Career Development Award (MR/S007091/1) . DEJ
   was supported by an Australian Research Council Laureate Fellowship.
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NR 283
TC 27
Z9 28
U1 3
U2 40
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0891-5849
EI 1873-4596
J9 FREE RADICAL BIO MED
JI Free Radic. Biol. Med.
PD FEB 1
PY 2022
VL 179
BP 339
EP 362
DI 10.1016/j.freeradbiomed.2021.11.007
EA JAN 2022
PG 24
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA YY1YV
UT WOS:000754590700005
PM 34775001
DA 2025-06-11
ER

PT J
AU Nikooyeh, B
   Hollis, BW
   Neyestani, TR
AF Nikooyeh, Bahareh
   Hollis, Bruce W.
   Neyestani, Tirang R.
TI The effect of daily intake of vitamin D-fortified yogurt drink, with and
   without added calcium, on serum adiponectin and sirtuins 1 and 6 in
   adult subjects with type 2 diabetes
SO NUTRITION & DIABETES
LA English
DT Article
ID GLOBAL ECONOMIC BURDEN; INSULIN-RESISTANCE; METABOLIC SYNDROME; D
   SUPPLEMENTATION; OXIDATIVE STRESS; GLUCOSE; SIRT1; POPULATION;
   SECRETION; OBESITY
AB Background Some evidence suggests indirect ameliorating effects of vitamin D in diabetes via adiponectin and sirtuins. This study aimed to evaluate the effects of daily intake of vitamin D-fortified yogurt drink, either with or without added calcium, on serum adiponectin, sirtuins (SIRT)1 and 6. Methods Briefly, 75 adults aged 30-60 years from both sexes with type 2 diabetes were randomly allocated to one of the three groups: (i) D-fortified-yogurt drink (DY; containing 1000 IU vitamin D and 300 mg calcium), (ii) Ca+D-fortified-yogurt drink (CDY; containing 1000 IU vitamin D and 500 mg calcium) and (iii) plain yogurt drink (PY; containing no detectable vitamin D and 300 mg calcium). All assessments were performed initially and after 12 weeks. Results A significant within-group increment in serum adiponectin concentrations was observed in both DY and CDY groups (+60.4 +/- 8.6, +57.5 +/- 6.4 mu g/L, respectively; p < 0.001 for both). The concentrations of SIRT1 and SIRT6 had a significant within-group increment only in the CDY group (p = 0.003, p = 0.001 respectively). Being in CDY group was more favorable predictor of improvement in SIRT6 concentrations. Changes of 25(OH)D were a significant predictor of changes of adiponectin. However, this association disappeared following adjustment for changes of SIRT1. In contrast, the association between changes of 25(OH)D and HbA1c remained significant even after adjustment for SIRT1. Conclusions Daily consumption of vitamin D-fortified yogurt drink for 12 weeks resulted in an increase in circulating concentrations of SIRT1 and SIRT6 in T2D subjects and D+Ca-fortified yogurt drink was more in favor of SIRT6 increment.
C1 [Nikooyeh, Bahareh; Neyestani, Tirang R.] Shahid Beheshti Univ Med Sci, Natl Nutr & Food Technol Res Inst, Lab Nutr Res, Tehran, Iran.
   [Nikooyeh, Bahareh; Neyestani, Tirang R.] Shahid Beheshti Univ Med Sci, Fac Nutr Sci & Food Technol, Tehran, Iran.
   [Hollis, Bruce W.] Med Univ South Carolina, Dept Pediat, Div Neonatol, Charleston, SC 29425 USA.
C3 Shahid Beheshti University Medical Sciences; Shahid Beheshti University
   Medical Sciences; Medical University of South Carolina
RP Neyestani, TR (corresponding author), Shahid Beheshti Univ Med Sci, Natl Nutr & Food Technol Res Inst, Lab Nutr Res, Tehran, Iran.; Neyestani, TR (corresponding author), Shahid Beheshti Univ Med Sci, Fac Nutr Sci & Food Technol, Tehran, Iran.
EM t.neyestani@sbmu.ac.ir
RI Nikooyeh, Bahareh/AAV-9064-2020; Neyestani, Tirang R./AAV-9024-2020
OI Nikooyeh, Bahareh/0000-0002-0823-7593; Neyestani, Tirang
   R./0000-0002-0953-2594
FU Shahid Beheshti Medical University [13945]
FX All laboratory bench works were performed at the Laboratory of Nutrition
   Research, NNFTTRI. We wish to thank all the subjects who assisted us by
   their sincere participation in this project. This study received no
   fund. This study was received a funding grant from Shahid Beheshti
   Medical University to Professor Tirang R. Neyestani for publication in
   high impact (> 4) journals (No. 13945).
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NR 65
TC 9
Z9 10
U1 0
U2 8
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 2044-4052
J9 NUTR DIABETES
JI Nutr. Diabetes
PD JUL 30
PY 2021
VL 11
IS 1
AR 26
DI 10.1038/s41387-021-00168-x
PG 8
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA UC6LF
UT WOS:000686634700001
PM 34389701
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Lee, JH
   Fang, C
   Li, X
   Wu, CS
   Noh, JY
   Ye, XC
   Chapkin, RS
   Sun, K
   Sun, YX
AF Lee, Jong Han
   Fang, Chuo
   Li, Xin
   Wu, Chia Shan
   Noh, Ji Yeon
   Ye, Xiangcang
   Chapkin, Robert S.
   Sun, Kai
   Sun, Yuxiang
TI GHS-R suppression in adipose tissues protects against obesity and
   insulin resistance by regulating adipose angiogenesis and fibrosis
SO INTERNATIONAL JOURNAL OF OBESITY
LA English
DT Article
ID GHRELIN RECEPTOR; ENERGY-METABOLISM; BROWN; ADIPONECTIN; EXPRESSION;
   INCREASE; WHITE; GAMMA; THERMOGENESIS; INFLAMMATION
AB Background/Objectives Ghrelin is an orexigenic hormone that increases food intake, adiposity, and insulin resistance through its receptor Growth Hormone Secretagogue Receptor (GHS-R). We previously showed that ghrelin/GHS-R signaling has important roles in regulation of energy homeostasis, and global deletion of GHS-R reduces obesity and improves insulin sensitivity by increasing thermogenesis. However, it is unknown whether GHS-R regulates thermogenic activation in adipose tissues directly. Methods We generated a novel adipose tissue-specific GHS-R deletion mouse model and characterized the mice under regular diet (RD) and high-fat diet (HFD) feeding. Body composition was measured by Echo MRI. Metabolic profiling was determined by indirect calorimetry. Response to environmental stress was assessed using a TH-8 temperature monitoring system. Insulin sensitivity was evaluated by glucose and insulin tolerance tests. Tissue histology was analyzed by hematoxylin/eosin and immunofluorescent staining. Expression of genes involved in thermogenesis, angiogenesis and fibrosis in adipose tissues were analyzed by real-time PCR. Results Under RD feeding, adipose tissue-specific GHS-R deletion had little or no impact on metabolic parameters. However, under HFD feeding, adipose tissue-specific GHS-R deletion attenuated diet-induced obesity and insulin resistance, showing elevated physical activity and heat production. In addition, adipose tissue-specific GHS-R deletion increased expression of master adipose transcription regulator of peroxisome proliferator-activated receptor (PPAR) gamma 1 and adipokines of adiponectin and fibroblast growth factor (FGF) 21; and differentially modulated angiogenesis and fibrosis evident in both gene expression and histological analysis. Conclusions These results show that GHS-R has cell-autonomous effects in adipocytes, and suppression of GHS-R in adipose tissues protects against diet-induced obesity and insulin resistance by modulating adipose angiogenesis and fibrosis. These findings suggest adipose GHS-R may constitute a novel therapeutic target for treatment of obesity and metabolic syndrome.
C1 [Lee, Jong Han; Sun, Yuxiang] Baylor Coll Med, Dept Pediat, USDA ARS, Childrens Nutr Res Ctr, Houston, TX 77030 USA.
   [Lee, Jong Han] Hanseo Univ, Dept Marine Bio & Med Sci, Seosan, South Korea.
   [Fang, Chuo] Texas A&M Univ, Dept Nutr & Food Sci, College Stn, TX USA.
   [Li, Xin; Sun, Kai] Univ Texas Hlth Sci Ctr Houston, Brown Fdn Inst Mol Med Prevent Human Dis, Ctr Metab & Degenerat Dis, Houston, TX 77030 USA.
   [Wu, Chia Shan; Noh, Ji Yeon; Ye, Xiangcang; Chapkin, Robert S.; Sun, Yuxiang] Texas A&M Univ, Dept Nutr, College Stn, TX 77843 USA.
C3 Baylor College of Medicine; United States Department of Agriculture
   (USDA); Hanseo University; Texas A&M University System; Texas A&M
   University College Station; University of Texas System; University of
   Texas Health Science Center Houston; Texas A&M University System; Texas
   A&M University College Station
RP Sun, YX (corresponding author), Baylor Coll Med, Dept Pediat, USDA ARS, Childrens Nutr Res Ctr, Houston, TX 77030 USA.; Sun, YX (corresponding author), Texas A&M Univ, Dept Nutr, College Stn, TX 77843 USA.
EM Yuxiang.Sun@tamu.edu
RI Wu, Chia/AAH-7825-2020; Noh, Ji Yeon/KIL-2679-2024
OI Chapkin, Robert/0000-0002-6515-3898; Sun, Kai/0000-0002-4778-4549; Noh,
   Ji Yeon/0000-0002-3160-9957; Wu, Chia Shan/0000-0002-6034-939X
FU NIH [1R01DK118334, AG064869, P30 ES029067, DK109001]; BrightFocus
   [A2019630S]; USDA National Institute of Food and Agriculture [1010840,
   NE1939]; National Institute of Diabetes and Digestive and Kidney
   Diseases [R01DK109001] Funding Source: NIH RePORTER; National Institute
   of Environmental Health Sciences [P30ES029067] Funding Source: NIH
   RePORTER
FX Metabolic analysis was performed in the Mouse Metabolic Research Unit at
   the USDA/ARS Children's Nutrition Research Center (CNRC), Baylor College
   of Medicine. This study was supported by NIH 1R01DK118334 and AG064869,
   and BrightFocus A2019630S (YS). This work was also supported in part by
   the USDA National Institute of Food and Agriculture Hatch project
   1010840 and Multistate Research NE1939 (YS), NIH P30 ES029067(PI: David
   Threadgill), and NIH DK109001 (KS).
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NR 51
TC 11
Z9 11
U1 0
U2 6
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0307-0565
EI 1476-5497
J9 INT J OBESITY
JI Int. J. Obes.
PD JUL
PY 2021
VL 45
IS 7
BP 1565
EP 1575
DI 10.1038/s41366-021-00820-7
EA APR 2021
PG 11
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA TC6CR
UT WOS:000644331600001
PM 33903722
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Ivancovsky-Wajcman, D
   Zelber-Sagi, S
   Isakov, NF
   Webb, M
   Zemel, M
   Shibolet, O
   Kariv, R
AF Ivancovsky-Wajcman, Dana
   Zelber-Sagi, Shira
   Isakov, Naomi Fliss
   Webb, Muriel
   Zemel, Meir
   Shibolet, Oren
   Kariv, Revital
TI Serum Soluble Receptor for AGE (sRAGE) Levels Are Associated With
   Unhealthy Lifestyle and Nonalcoholic Fatty Liver Disease
SO CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY
LA English
DT Article
ID GLYCATION END-PRODUCTS; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   OXIDATIVE STRESS; MEAT CONSUMPTION; RISK; DIET; NAFLD; RESTRICTION;
   PREVALENCE
AB OBJECTIVES: Nonalcoholic fatty liver disease (NAFLD) has been demonstrated to be positively associated with serum advanced glycation end products (AGEs) and negatively with soluble receptor for AGE (sRAGE) in a few small studies. We aimed to test the association between lifestyle and sRAGE levels and the association between sRAGE levels or AGEs intake and NAFLD, insulin resistance (IR), and elevated alanine aminotransferase (ALT).
   METHODS: Cross-sectional analysis among participants of a screening study. Fasting blood tests and serum sRAGE levels were obtained. NAFLD and insulin resistance were evaluated by ultrasonography and homeostasis model assessment, respectively. Nutritional intake was measured by food frequency questionnaire, and the intake of dietary AGEs was calculated.
   RESULTS: A total of 743 subjects were included (52.6% men, mean age 58.83 +/- 6.58 years, 38.7% NAFLD). Exercise was independently protective from low sRAGE levels (odds ratio [OR] = 0.71, 95% confidence interval 0.52-0.97, P = 0.031). Pack-years, working time, and sedentary time (OR = 1.51, 1.03-2.22, P = 0.036; OR = 1.66, 1.18-2.35, P = 0.004; OR = 1.64, 1.18-2.29, P = 0.004, respectively), and intake of red and/or processed meat or processed meat alone (OR = 1.01, 1.04-2.21, P = 0.045; OR = 1.49, 1.00-2.21, P = 0.048, respectively) were associated with increased odds for low sRAGE levels. Low sRAGE levels were independently associated with elevated ALT (OR = 1.69, 1.11-2.57, P = 0.014) and NAFLD with elevated ALT (OR = 2.17, 1.23-3.83, P = 0.007). High intake of dietary AGEs was associated with IR (OR = 2.04, 1.25-3.34 P = 0.004).
   DISCUSSION: Lifestyle is associated with sRAGE levels and, in turn, low levels of sRAGE are associated with NAFLD and elevated ALT.
C1 [Ivancovsky-Wajcman, Dana; Zelber-Sagi, Shira] Univ Haifa, Sch Publ Hlth, Haifa, Israel.
   [Zelber-Sagi, Shira; Isakov, Naomi Fliss; Webb, Muriel; Shibolet, Oren; Kariv, Revital] Tel Aviv Med Ctr & Sch Med, Dept Gastroenterol, Tel Aviv, Israel.
   [Webb, Muriel; Shibolet, Oren; Kariv, Revital] Tel Aviv Univ, Sackler Fac Med, Tel Aviv, Israel.
   [Zemel, Meir] Tel Aviv Med Ctr & Sch Med, Dept Surg, Tel Aviv, Israel.
C3 University of Haifa; Tel Aviv University; Sackler Faculty of Medicine;
   Tel Aviv University; Sackler Faculty of Medicine; Tel Aviv University;
   Sackler Faculty of Medicine
RP Zelber-Sagi, S (corresponding author), Univ Haifa, Sch Publ Hlth, Haifa, Israel.; Zelber-Sagi, S (corresponding author), Tel Aviv Med Ctr & Sch Med, Dept Gastroenterol, Tel Aviv, Israel.
EM zelbersagi@bezeqint.net
RI Kariv, Revital/HLW-2074-2023; ivancovsky, dana/HDO-6146-2022
FU Research Grants and Fellowships Fund on Food and Nutrition and their
   Implications on Public Health, The Israeli Ministry of Health
FX Research Grants and Fellowships Fund on Food and Nutrition and their
   Implications on Public Health, The Israeli Ministry of Health.
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NR 53
TC 12
Z9 12
U1 0
U2 8
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
EI 2155-384X
J9 CLIN TRANSL GASTROEN
JI Clin. Transl. Gastroenterol.
PD MAY 10
PY 2019
VL 10
AR e-00040
DI 10.14309/ctg.0000000000000040
PG 10
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA HZ6YC
UT WOS:000468997400001
PM 31082855
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Schinzari, F
   Tesauro, M
   Veneziani, A
   Mores, N
   Di Daniele, N
   Cardillo, C
AF Schinzari, Francesca
   Tesauro, Manfredi
   Veneziani, Augusto
   Mores, Nadia
   Di Daniele, Nicola
   Cardillo, Carmine
TI Favorable Vascular Actions of Angiotensin-(1-7) in Human Obesity
SO HYPERTENSION
LA English
DT Article
DE angiotensin; endothelin-1; endothelium; insulin; obesity
ID IMPROVES ENDOTHELIAL FUNCTION; ADIPOSE-TISSUE INFLAMMATION; CARDIAC
   DYSFUNCTION; INSULIN-RESISTANCE; METABOLIC SYNDROME; OXIDATIVE STRESS;
   BLOOD-PRESSURE; NITRIC-OXIDE; 1-7 AXIS; VASODILATOR
AB Obese patients have vascular dysfunction related to impaired insulin-stimulated vasodilation and increased endothelin-1-mediated vasoconstriction. In contrast to the harmful vascular actions of angiotensin (Ang) II, the angiotensin-converting enzyme 2 product Ang-(1-7) has shown to exert cardiovascular and metabolic benefits in experimental models through stimulation of the Mas receptor. We, therefore, examined the effects of exogenous Ang-(1-7) on vasodilator tone and endothelin-1-dependent vasoconstriction in obese patients. Intra-arterial infusion of Ang-(1-7) (10 nmol/min) resulted in significant increase in unstimulated forearm flow (P=0.03), an effect that was not affected by the Mas receptor antagonist A779 (10 nmol/min; P>0.05). In the absence of hyperinsulinemia, however, forearm flow responses to graded doses of acetylcholine and sodium nitroprusside were not different during Ang-(1-7) administration compared with saline (both P>0.05). During infusion of regular insulin (0.15 mU/kg per minute), by contrast, endothelium-dependent vasodilator response to acetylcholine was significantly enhanced by Ang-(1-7) (P=0.04 versus saline), whereas endothelium-independent response to sodium nitroprusside was not modified (P=0.91). Finally, Ang-(1-7) decreased the vasodilator response to endothelin A receptor blockade (BQ-123; 10 nmol/min) compared with saline (6 +/- 1% versus 93 +/- 17%; P<0.001); nitric oxide inhibition by l-N-monomethylarginine (4 mu mol/min) during concurrent endothelin A antagonism resulted in similar vasoconstriction in the absence or presence of Ang-(1-7 Ang-(1-7) (P=0.69). Our findings indicate that in obese patients Ang-(1-7) has favorable effects not only to improve insulin-stimulated endothelium-dependent vasodilation but also to blunt endothelin-1-dependent vasoconstrictor tone. These findings provide support for targeting Ang-(1-7) to counteract the hemodynamic abnormalities of human obesity.
C1 [Schinzari, Francesca; Veneziani, Augusto; Mores, Nadia; Cardillo, Carmine] Policlin A Gemelli, Rome, Italy.
   [Tesauro, Manfredi; Di Daniele, Nicola] Univ Tor Vergata, Dept Internal Med, Rome, Italy.
   [Veneziani, Augusto] Catholic Univ, Dept Surg, Rome, Italy.
   [Mores, Nadia] Catholic Univ, Dept Pharmacol, Rome, Italy.
   [Cardillo, Carmine] Catholic Univ, Dept Internal Med, Rome, Italy.
C3 Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli;
   University of Rome Tor Vergata; Catholic University of the Sacred Heart;
   IRCCS Policlinico Gemelli; Catholic University of the Sacred Heart;
   IRCCS Policlinico Gemelli; Catholic University of the Sacred Heart;
   IRCCS Policlinico Gemelli
RP Cardillo, C (corresponding author), Univ Cattolica Sacro Cuore, Ist Patol Speciale Med & Semeiot Med, Largo Gemelli 8, I-00168 Rome, Italy.
EM carmine.cardillo@unicatt.it
RI schinzari, francesca/AAB-9982-2019
OI Cardillo, Carmine/0000-0001-5182-3005
FU Ministero della Salute [RF-2010-2313809]; Fondazione Roma
   [NCDS-2013-00000308]; Fondi d'Ateneo grants from the Universita
   Cattolica del Sacro Cuore; Fondazione Roma
FX This work was supported by a grant from the Ministero della Salute
   (RF-2010-2313809) and by a grant from the Fondazione Roma
   (NCDS-2013-00000308) to C. Cardillo, who is also supported by Fondi
   d'Ateneo grants from the Universita Cattolica del Sacro Cuore. M.
   Tesauro and N. Di Daniele are both supported by grants from the
   Fondazione Roma.
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NR 50
TC 46
Z9 47
U1 0
U2 9
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0194-911X
EI 1524-4563
J9 HYPERTENSION
JI Hypertension
PD JAN
PY 2018
VL 71
IS 1
BP 185
EP 191
DI 10.1161/HYPERTENSIONAHA.117.10280
PG 7
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA FP9BQ
UT WOS:000417942900029
PM 29203627
OA Bronze
DA 2025-06-11
ER

PT J
AU Zhou, M
   Learned, RM
   Rossi, SJ
   DePaoli, AM
   Tian, H
   Ling, L
AF Zhou, Mei
   Learned, R. Marc
   Rossi, Stephen J.
   DePaoli, Alex M.
   Tian, Hui
   Ling, Lei
TI Engineered FGF19 Eliminates Bile Acid Toxicity and Lipotoxicity Leading
   to Resolution of Steatohepatitis and Fibrosis in Mice
SO HEPATOLOGY COMMUNICATIONS
LA English
DT Article
ID FATTY LIVER-DISEASE; FIBROBLAST GROWTH FACTOR-19; NONALCOHOLIC
   STEATOHEPATITIS; HEPATOCELLULAR-CARCINOMA; MOUSE MODEL; ACTIVATION;
   OBESITY; STRESS; LIPIDS; NASH
AB Nonalcoholic fatty liver disease (NAFLD) is an increasingly prevalent chronic liver disease for which no approved therapies are available. Despite intensive research, the cellular mechanisms that mediate NAFLD pathogenesis and progression are poorly understood. Although obesity, diabetes, insulin resistance, and related metabolic syndrome, all consequences of a Western diet lifestyle, are well-recognized risk factors for NAFLD development, dysregulated bile acid metabolism is emerging as a novel mechanism contributing to NAFLD pathogenesis. Notably, NAFLD patients exhibit a deficiency in fibroblast growth factor 19 (FGF19), an endocrine hormone in the gut-liver axis that controls de novo bile acid synthesis, lipogenesis, and energy homeostasis. Using a mouse model that reproduces the clinical progression of human NAFLD, including the development of simple steatosis, nonalcoholic steatohepatitis (NASH), and advanced "burnt-out" NASH with hepatocellular carcinoma, we demonstrate that FGF19 as well as an engineered nontumorigenic FGF19 analogue, M70, ameliorate bile acid toxicity and lipotoxicity to restore liver health. Mass spectrometry-based lipidomics analysis of livers from mice treated with FGF19 or M70 revealed significant reductions in the levels of toxic lipid species (i.e., diacylglycerols, ceramides and free cholesterol) and an increase in levels of unoxidized cardiolipins, an important component of the inner mitochondrial membrane. Furthermore, treatment with FGF19 or M70 rapidly and profoundly reduced levels of liver enzymes, resolved the histologic features of NASH, and enhanced insulin sensitivity, energy homeostasis, and lipid metabolism. Whereas FGF19 induced hepatocellular carcinoma formation following prolonged exposure in these mice, animals expressing M70 showed no evidence of liver tumorigenesis in this model. Conclusion: We have engineered an FGF19 hormone that is capable of regulating multiple pathways to deliver antisteatotic, anti-inflammatory, and antifibrotic activities and that represents a potentially promising therapeutic for patients with NASH.
C1 [Zhou, Mei; Learned, R. Marc; Rossi, Stephen J.; DePaoli, Alex M.; Tian, Hui; Ling, Lei] NGM Biopharmaceut Inc, 333 Oyster Point Blvd, San Francisco, CA 94080 USA.
RP Ling, L (corresponding author), NGM Biopharmaceut Inc, 333 Oyster Point Blvd, San Francisco, CA 94080 USA.
EM lling@ngmbio.com
FU NGM Biopharmaceuticals, Inc.
FX Supported by NGM Biopharmaceuticals, Inc.
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NR 48
TC 114
Z9 129
U1 1
U2 10
PU JOHN WILEY & SONS LTD
PI CHICHESTER
PA THE ATRIUM, SOUTHERN GATE, CHICHESTER PO19 8SQ, W SUSSEX, ENGLAND
EI 2471-254X
J9 HEPATOL COMMUN
JI Hepatol. Commun.
PD DEC
PY 2017
VL 1
IS 10
BP 1024
EP 1042
DI 10.1002/hep4.1108
PG 19
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA HE2SD
UT WOS:000453177500005
PM 29404440
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Kawamoto, R
   Ninomiya, D
   Senzaki, K
   Kasai, Y
   Kusunoki, T
   Ohtsuka, N
   Kumagi, T
AF Kawamoto, Ryuichi
   Ninomiya, Daisuke
   Senzaki, Kensuke
   Kasai, Yoshihisa
   Kusunoki, Tomo
   Ohtsuka, Nobuyuki
   Kumagi, Teru
TI Interactive association of serum uric acid and total bilirubin with
   renal dysfunction among community-dwelling subjects
SO INTERNATIONAL UROLOGY AND NEPHROLOGY
LA English
DT Article
DE Total bilirubin; Serum uric acid; Confounding factor; eGFR; Interaction;
   Community-dwelling person
ID CHRONIC KIDNEY-DISEASE; RISK-FACTOR; CARDIOVASCULAR-DISEASE; METABOLIC
   SYNDROME; POPULATION; ATHEROSCLEROSIS; ADULTS; HYPERTENSION; PREVALENCE;
   PROTEIN
AB Chronic kidney disease is a major public health concern. Serum uric acid (SUA) at high levels was oxidative stress agents, and total bilirubin (T-BiL) at mildly increased levels was potent antioxidants, but whether SUA and T-BiL produce an additive interaction for the risk of renal dysfunction remains unclear.
   The subjects comprised 567 men aged 71 +/- 8 (mean +/- standard deviation) years and 853 women aged 70 +/- 8 years from a rural village. We examined the relationship between SUA and T-BiL, and renal function was evaluated by estimated glomerular filtration rate (eGFR) using the Modification of Diet in Renal Disease Study Group equation.
   Stepwise multiple regression analysis using eGFR as an objective variable, adjusted for risk factors as explanatory variables, showed that SUA (beta = -0.358, p < 0.001) as well as age (beta = -0.534, p < 0.001), drinking status (beta = 0.119, p < 0.001), and the presence of antihypertensive medication (beta = -0.058, p = 0.005) were significantly and independently associated with eGFR, but T-BiL was not associated with eGFR. While in the group with the highest tertile of SUA, T-BiL (beta = 0.081, p = 0.032) was significantly and independently associated with eGFR, and in the group with the lowest to middle tertile of SUA, T-BiL was not associated with eGFR. In addition, interaction between SUA and T-BiL (F = 8.512, p = 0.004) as well as age, drinking status, the presence of antihypertensive medication, SUA, and T-BiL was a significant and independent determinant for eGFR.
   Our data demonstrated that low T-BiL could be important as a potential risk factor for renal dysfunction in those with high SUA.
C1 [Kawamoto, Ryuichi; Ninomiya, Daisuke; Senzaki, Kensuke; Kumagi, Teru] Ehime Univ, Dept Community Med, Grad Sch Med, Toon City 7910295, Japan.
   [Kawamoto, Ryuichi; Ninomiya, Daisuke; Senzaki, Kensuke; Kasai, Yoshihisa; Kusunoki, Tomo; Ohtsuka, Nobuyuki] Seiyo Municipal Nomura Hosp, Dept Internal Med, 9-53 Nomura,Nomura Cho, Seiyo 7971212, Japan.
C3 Ehime University
RP Kawamoto, R (corresponding author), Ehime Univ, Dept Community Med, Grad Sch Med, Toon City 7910295, Japan.; Kawamoto, R (corresponding author), Seiyo Municipal Nomura Hosp, Dept Internal Med, 9-53 Nomura,Nomura Cho, Seiyo 7971212, Japan.
EM rykawamo@m.ehime-u.ac.jp
RI Kumagi, Teru/AAS-7427-2021
OI Kawamoto, Ryuichi/0000-0003-4674-0787; Kumagi, Teru/0000-0002-2292-7750
FU Foundation for Development of Community
FX This work was supported in part by a grant-in-aid from the Foundation
   for Development of Community (2017).
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NR 35
TC 5
Z9 6
U1 0
U2 7
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0301-1623
EI 1573-2584
J9 INT UROL NEPHROL
JI Int. Urol. Nephrol.
PD AUG
PY 2017
VL 49
IS 8
BP 1439
EP 1446
DI 10.1007/s11255-017-1633-8
PG 8
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA FB5RI
UT WOS:000406199200018
PM 28573490
DA 2025-06-11
ER

PT J
AU Persico, M
   Masarone, M
   Damato, A
   Ambrosio, M
   Federico, A
   Rosato, V
   Bucci, T
   Carrizzo, A
   Vecchione, C
AF Persico, Marcello
   Masarone, Mario
   Damato, Antonio
   Ambrosio, Mariateresa
   Federico, Alessandro
   Rosato, Valerio
   Bucci, Tommaso
   Carrizzo, Albino
   Vecchione, Carmine
TI "Non alcoholic fatty liver disease and eNOS dysfunction in humans"
SO BMC GASTROENTEROLOGY
LA English
DT Article
DE Non-alcoholic fatty liver disease; Endothelial dysfunction; Metabolic
   syndrome; Insulin resistance
ID NITRIC-OXIDE SYNTHASE; FLOW-MEDIATED VASODILATION; ENDOTHELIAL
   DYSFUNCTION; INSULIN-RESISTANCE; OXIDATIVE STRESS; VASCULAR FUNCTION;
   BRACHIAL-ARTERY; RISK; MICROCIRCULATION; ASSOCIATION
AB Background: NAFLD is associated to Insulin Resistance (IR). IR is responsible for Endothelial Dysfunction (ED) through the impairment of eNOS function. Although eNOS derangement has been demonstrated in experimental models, no studies have directly shown that eNOS dysfunction is associated with NAFLD in humans. The aim of this study is to investigate eNOS function in NAFLD patients.
   Methods: Fifty-four NAFLD patients were consecutively enrolled. All patients underwent clinical and laboratory evaluation and liver biopsy. Patients were divided into two groups by the presence of NAFL or NASH. We measured vascular reactivity induced by patients' platelets on isolated mice aorta rings. Immunoblot assays for platelet-derived phosphorylated-eNOS (p-eNOS) and immunohistochemistry for hepatic p-eNOS have been performed to evaluate eNOS function in platelets and liver specimens. Flow-mediated-dilation (FMD) was also performed. Data were compared with healthy controls.
   Results: Twenty-one (38, 8%) patients had NAFL and 33 (61, 7%) NASH. No differences were found between groups and controls except for HOMA and insulin (p < 0.0001). Vascular reactivity demonstrated a reduced function induced from NAFLD platelets as compared with controls (p < 0.001), associated with an impaired p-eNOS in both platelets and liver (p < 0.001). NAFL showed a higher impairment of eNOS phosphorylation in comparison to NASH (p < 0.01). In contrast with what observed in vitro, the vascular response by FMD was worse in NASH as compared with NAFL.
   Conclusions: Our data showed, for the first time in humans, that NAFLD patients show a marked eNOS dysfunction, which may contribute to a higher CV risk. eNOS dysfunction observed in platelets and liver tissue didn't match with FMD.
C1 [Persico, Marcello; Masarone, Mario; Bucci, Tommaso] Univ Salerno, PO G Da Procida AOU San Giovanni & Ruggi DAragona, Internal Med & Hepatol Unit, Via Salvatore Calenda 162, I-84126 Salerno, Italy.
   [Damato, Antonio; Ambrosio, Mariateresa; Carrizzo, Albino] INM Neuromed, Vasc Physiopathol Unit IRCCS, Pozzilli, IS, Italy.
   [Federico, Alessandro] Univ Campania L Vanvitelli, Hepatogastroenterol Div, Naples, Italy.
   [Rosato, Valerio] Univ Campania L Vanvitelli, Internal Med & Hepatol Dept, Naples, Italy.
   [Vecchione, Carmine] Univ Salerno, Dept Med & Surg, Salerno, Italy.
C3 University of Salerno; IRCCS Neuromed; Universita della Campania
   Vanvitelli; Universita della Campania Vanvitelli; University of Salerno
RP Persico, M (corresponding author), Univ Salerno, PO G Da Procida AOU San Giovanni & Ruggi DAragona, Internal Med & Hepatol Unit, Via Salvatore Calenda 162, I-84126 Salerno, Italy.
EM mpersico@unisa.it
RI Federico, Alessandro/AAB-3893-2019; Rosato, Valerio/ABB-9874-2020;
   Vecchione, Carmine/K-2175-2018; persico, marcello/AAB-3562-2019;
   Masarone, Mario/H-8633-2017; Bucci, Tommaso/ABA-4162-2021; Carrizzo,
   Albino/K-5177-2016; Damato, Antonio/K-5307-2016
OI Federico, Alessandro/0000-0002-0885-0793; Masarone,
   Mario/0000-0003-0550-8201; Ambrosio, Mariateresa/0000-0002-9744-3144;
   Bucci, Tommaso/0000-0003-2895-6234; Carrizzo,
   Albino/0000-0003-2689-0008; Damato, Antonio/0000-0003-0258-5324;
   Vecchione, Carmine/0000-0002-2473-4565; Persico,
   Marcello/0000-0002-1399-6498; Rosato, Valerio/0000-0002-3584-2414
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NR 55
TC 46
Z9 49
U1 0
U2 3
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1471-230X
J9 BMC GASTROENTEROL
JI BMC Gastroenterol.
PD MAR 7
PY 2017
VL 17
AR 35
DI 10.1186/s12876-017-0592-y
PG 9
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA EN5WU
UT WOS:000396077300001
PM 28264657
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Skarpanska-Stejnborn, A
   Basta, P
   Trzeciak, J
   Michalska, A
   Kafkas, ME
   Woitas-Slubowska, D
AF Skarpanska-Stejnborn, Anna
   Basta, Piotr
   Trzeciak, Jerzy
   Michalska, Alicja
   Kafkas, M. Emin
   Woitas-Slubowska, Donata
TI Effects of cranberry (Vaccinum macrocarpon) supplementation on
   iron status and inflammatory markers in rowers
SO JOURNAL OF THE INTERNATIONAL SOCIETY OF SPORTS NUTRITION
LA English
DT Article
DE Cranberry; Supplementation; Strenuous exercise; Inflammation
ID PLASMA ANTIOXIDANT CAPACITY; OXIDATIVE STRESS; LIPID-PEROXIDATION;
   METABOLIC SYNDROME; IN-VITRO; EX-VIVO; JUICE; HEPCIDIN; EXERCISE;
   INCREASES
AB Background: The aim of this study was to analyze the effect of supplementation with cranberry (Vaccinum macrocarpon) on the levels of pro-inflammatory cytokines, hepcidin and selected markers of iron metabolism in rowers subjected to exhaustive exercise.
   Methods: This double-blind study included 16 members of the Polish Rowing Team. The subjects were randomly assigned to the supplemented group (n = 9), receiving 1200 mg of cranberry extract for 6 weeks, or to the placebo group (n = 7). The participants performed a 2000-m test on a rowing ergometer at the beginning and at the end of the preparatory camp. Blood samples were obtained from the antecubital vein prior to each exercise test, one minute after completing the test, and after a 24-h recovery period. The levels of hepcidin, interleukin 6 (IL-6), tumor necrosis factor alpha (TNF-alpha), ferritin, iron, soluble transferrin receptor (sTfR) and myoglobin were determined, along with total iron-binding capacity (TIBC), unbound iron-binding capacity (UIBC) and total antioxidant capacity (TAC).
   Results: Both prior and after the supplementation, a significant post-exercise increase in the concentration of IL-6 was observed in both groups. At the end of the study period, cranberry-supplemented athletes presented with significantly higher resting, post-exercise and post-recovery levels of TAC than the controls. However, a significant exercise-induced increase in the concentrations of TNF-alpha, myoglobin and hepcidin was observed solely in the control group.
   Conclusion: Supplementation with cranberry extract contributed to a significant strengthening of antioxidant potential in individuals exposed to strenuous physical exercise. However, supplementation did not exert direct effects on other analyzed parameters: inflammatory markers and indices of iron metabolism (TNF-alpha, hepcidin and myoglobin).
C1 [Skarpanska-Stejnborn, Anna; Michalska, Alicja] Fac Phys Culture Gorzow Wlkp, Dept Morphol & Hlth Sci, 13 Estkowskiego Str, PL-66400 Gorzow Wielkopolski, Poland.
   [Basta, Piotr] Univ Sch Phys Educ Poznan, Branch Gorzow Wlkp, Fac Phys Culture, Water Sports, Gorzow Wielkopolski, Poland.
   [Trzeciak, Jerzy] Univ Sch Phys Educ Poznan, Branch Gorzow Wlkp, Gorzow Wielkopolski, Poland.
   [Kafkas, M. Emin] Inonu Univ, Sch Phys Educ & Sport, Dept Coaching Educ, Malatya, Turkey.
   [Woitas-Slubowska, Donata] Kazimierz Wielki Univ, Fac Phys Educ Hlth & Tourism, Bydgoszcz, Poland.
C3 Poznan University of Physical Education; Poznan University of Physical
   Education; Inonu University; Kazimierz Wielki University
RP Skarpanska-Stejnborn, A (corresponding author), Fac Phys Culture Gorzow Wlkp, Dept Morphol & Hlth Sci, 13 Estkowskiego Str, PL-66400 Gorzow Wielkopolski, Poland.
EM ankass@poczta.onet.pl
RI kafkas, muhammed/S-4922-2019
OI Basta, Piotr/0000-0003-2439-3315; Skarpanska - Stejnborn,
   Anna/0000-0002-7795-3550
FU Polish Ministry of Science and Higher Education [N N404 256240]
FX This study was supported by a grant from the Polish Ministry of Science
   and Higher Education (project no. N N404 256240).
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NR 45
TC 20
Z9 21
U1 0
U2 18
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1550-2783
J9 J INT SOC SPORT NUTR
JI J. Int. Soc. Sport Nutr.
PD FEB 28
PY 2017
VL 14
AR 7
DI 10.1186/s12970-017-0165-z
PG 10
WC Nutrition & Dietetics; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics; Sport Sciences
GA EO9YE
UT WOS:000397043200001
PM 28261001
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Asghari, G
   Farhadnejad, H
   Mirmiran, P
   Dizavi, A
   Yuzbashian, E
   Azizi, F
AF Asghari, Golaleh
   Farhadnejad, Hossein
   Mirmiran, Parvin
   Dizavi, Alireza
   Yuzbashian, Emad
   Azizi, Fereidoun
TI Adherence to the Mediterranean diet is associated with reduced risk of
   incident chronic kidney diseases among Tehranian adults
SO HYPERTENSION RESEARCH
LA English
DT Article
DE chronic kidney disease; glomerular filtration rate; Mediterranean diet
ID GLOMERULAR-FILTRATION-RATE; STYLE DIET; METABOLIC SYNDROME; OXIDATIVE
   STRESS; BLOOD-PRESSURE; MIDDLE-EAST; INFLAMMATION; POPULATION; MARKERS;
   HYPERTENSION
AB Greater adherence to the Mediterranean diet has beneficial effects on the prevention of chronic diseases. In the current study, we investigated the association between the Mediterranean diet score (MDS) and the 6-year incidence of chronic kidney disease (CKD), conducted in the framework of the Tehran Lipid and Glucose Study with 1212 adults, aged 30-71 years. Dietary intake was assessed using a valid and reliable food-frequency questionnaire, and all subjects received scores between 0 and 8 points based on the traditional MDS. The components of the MDS were fruits and nuts, vegetables, legumes, cereals, fish, meat, dairy products and the monounsaturated to saturated fatty acid ratio. The odds ratio (OR) for the occurrence of CKD according to the quartiles of the MDS was assessed by multivariable logistic regression. The mean (s.d.) age of participants (51% male) at baseline was 43.5 (9.4) years. The median (25-75 interquartile range) of MDS for all subjects was 4 (3-5). The incidence of CKD was 19%. After adjustment for all potential confounding variables, individuals in the highest quartile of the MDS were 51% less likely to have CKD than those in the lowest quartile (OR=0.49; 95% confidence interval (CI): 0.30-0.82). Additionally, after further adjustment for baseline estimated glomerular filtration rate (GFR), the inverse association between the MDS and the 6-year incidence of CKD remained significant (OR= 0.53; 95% CI: 0.31-0.91). Our findings demonstrate a significant inverse association between the MDS and the risk of incident CKD, indicating that adherence to the Mediterranean diet has favorable effects on the prevention of kidney dysfunction.
C1 [Asghari, Golaleh] Res Inst Endocrine Sci, Nutr & Endocrine Res Ctr, Students Res Comm, Tehran, Iran.
   [Farhadnejad, Hossein; Mirmiran, Parvin; Dizavi, Alireza; Yuzbashian, Emad] Shahid Beheshti Univ Med Sci, Nutr & Endocrine Res Ctr, Res Inst Endocrine Sci, POB 19395-4763, Tehran, Iran.
   [Azizi, Fereidoun] Shahid Beheshti Univ Med Sci, Res Inst Endocrine Sci, Endocrine Res Ctr, Tehran, Iran.
C3 Shahid Beheshti University Medical Sciences; Shahid Beheshti University
   Medical Sciences
RP Mirmiran, P (corresponding author), Shahid Beheshti Univ Med Sci, Nutr & Endocrine Res Ctr, Res Inst Endocrine Sci, POB 19395-4763, Tehran, Iran.
EM mirmiran@endocrine.ac.ir
RI Yuzbashian, Emad/AAL-8268-2021; Mirmiran, Parvin/V-1433-2019; asghari,
   golaleh/N-4521-2013; Azizi, Fereidoun/ABD-4136-2021; Yuzbashian,
   Emad/HOI-0085-2023; Farhadnejad, Hossein/H-1405-2018
OI Mirmiran, Parvin/0000-0003-2391-4924; Asghari,
   Golaleh/0000-0002-7925-5158; Azizi, Fereidoun/0000-0002-6470-2517;
   Yuzbashian, Emad/0000-0002-1748-5978; Farhadnejad,
   Hossein/0000-0003-2201-5169
FU Research Institute for Endocrine Sciences; Shahid Beheshti University of
   Medical Sciences, Tehran, Iran
FX We express their appreciation to the participants in the Tehran Lipid
   and Glucose Study for their enthusiastic support and to the staff of the
   Research Institute for Endocrine Sciences, Tehran Lipid and Glucose
   Study Unit for their valuable help. We also wish to acknowledge Ms N
   Shiva for critically editing the English grammar and syntax of the
   manuscript. This work was funded by a grant from the Research Institute
   for Endocrine Sciences, Shahid Beheshti University of Medical Sciences,
   Tehran, Iran. All of the authors read and approved the final manuscript.
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NR 46
TC 66
Z9 68
U1 0
U2 6
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0916-9636
EI 1348-4214
J9 HYPERTENS RES
JI Hypertens. Res.
PD JAN
PY 2017
VL 40
IS 1
BP 96
EP 102
DI 10.1038/hr.2016.98
PG 7
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA EK9KF
UT WOS:000394242500015
PM 27511053
DA 2025-06-11
ER

PT J
AU Yanagihara, H
   Ushijima, K
   Arakawa, Y
   Aizawa, K
   Fujimura, A
AF Yanagihara, Hayato
   Ushijima, Kentaro
   Arakawa, Yusuke
   Aizawa, Ken-ichi
   Fujimura, Akio
TI Effects of telmisartan and olmesartan on insulin sensitivity and renal
   function in spontaneously hypertensive rats fed a high fat diet
SO JOURNAL OF PHARMACOLOGICAL SCIENCES
LA English
DT Article
DE Angiotensin II receptor blocker; Olmesartan; Proliferator-activated
   receptor-gamma; SHR fed a high fat diet; Telmisartan
ID RENIN-ANGIOTENSIN SYSTEM; ACTIVATED RECEPTOR-GAMMA; OXIDATIVE STRESS;
   DIABETIC-NEPHROPATHY; METABOLIC SYNDROME; PPAR-GAMMA; ADIPONECTIN;
   CANDESARTAN; RESISTANCE
AB Although telmisartan, an angiotensin II receptor blocker (ARB), has an agonistic action for proliferator-activated receptor (PPAR)-gamma in vitro, it remains to be determined whether telmisartan exerts such an action in vivo using a non-toxic dose (<5 mg/kg in rats). To address the issue, telmisartan (2 mg/kg) and olmesartan (2 mg/kg), another ARB without PPAR-gamma agonistic action, were given to spontaneously hypertensive rats (SHR) fed a high fat diet (HFD). HFD decreased plasma adiponectin, and caused insulin resistance, hypertriglyceridemia and renal damage, which were improved by ARBs. Protective effects of telmisartan and olmesartan did not significantly differ. In addition, in vitro study showed that 1 mu M of telmisartan did not elevate the mRNA expression of adipose protein 2, which is a PPAR-gamma-stimulated adipogenic marker gene, in preadipocytes with 3% albumin. To obtain 1 mu M of plasma concentration, oral dose of telmisartan was calculated to be 6 mg/kg, which indicates that PPAR-gamma agonistic action is negligible with a non-toxic dose of telmisartan (< 5 mg/kg) in rats. This study showed that 2 mg/kg of telmisartan and olmesartan ameliorated insulin resistance, hypertriglyceridemia and renal damage in SHR fed a HFD. As beneficial effects of telmisartan and olmesartan did not significantly differ, these were mediated through the PPAR-gamma-independent actions. (C) 2016 The Authors. Production and hosting by Elsevier B.V. on behalf of Japanese Pharmacological Society. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
C1 [Yanagihara, Hayato; Ushijima, Kentaro; Aizawa, Ken-ichi; Fujimura, Akio] Jichi Med Univ, Dept Pharmacol, Div Clin Pharmacol, Shimotsuke, Tochigi 3290498, Japan.
   [Arakawa, Yusuke] Nippon Med Univ, Dept Internal Med, Div Nephrol, Tokyo, Japan.
C3 Jichi Medical University; Nippon Medical School
RP Fujimura, A (corresponding author), Jichi Med Univ, Dept Pharmacol, Div Clin Pharmacol, Shimotsuke, Tochigi 3290498, Japan.
EM akiofuji@jichi.ac.jp
RI Ushijima, Kentaro/AAF-8690-2021
OI Ushijima, Kentaro/0000-0003-2637-3916
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NR 25
TC 15
Z9 16
U1 0
U2 2
PU JAPANESE PHARMACOLOGICAL SOC
PI KYOTO
PA EDITORIAL OFF, KANTOHYA BLDG GOKOMACHI-EBISUGAWA NAKAGYO-KU, KYOTO, 604,
   JAPAN
SN 1347-8613
EI 1347-8648
J9 J PHARMACOL SCI
JI J. Pharmacol. Sci.
PD JUL
PY 2016
VL 131
IS 3
BP 190
EP 197
DI 10.1016/j.jphs.2016.06.003
PG 8
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA DS9HT
UT WOS:000381094400005
PM 27430988
OA gold
DA 2025-06-11
ER

PT J
AU Lou, DF
   Li, YH
   Yan, GL
   Bu, JH
   Wang, HH
AF Lou, Danfei
   Li, Yuehua
   Yan, Guoliang
   Bu, Jianhong
   Wang, Haihui
TI Soy Consumption with Risk of Coronary Heart Disease and Stroke: A
   Meta-Analysis of Observational Studies
SO NEUROEPIDEMIOLOGY
LA English
DT Article
DE Stroke; Coronary heart disease; Meta-analysis; Soy consumption
ID METABOLIC SYNDROME; BLOOD-PRESSURE; MYOCARDIAL-INFARCTION; OXIDATIVE
   STRESS; DIETARY-INTAKE; PROTEIN; SUPPLEMENTATION; ASSOCIATION;
   ISOFLAVONES; PRODUCTS
AB Background: The association of soy product consumption with the relative risk of cardiovascular disease remains controversial. This meta-analysis aimed at investigating whether an association exists between soy consumption and the risk of stroke and coronary heart disease (CHD) in observational studies. Methods: A systematic search of the PubMed and EMBASE databases was performed for case control and cohort studies that assessed soy consumption and the risk of stroke and CHD. Summary relative risks (SRRs) and 95% CIs were combined by using a random-effects model. Results: Of a total of 1,266 abstracts, 5 prospective cohort and 6 case control studies met our inclusion criteria, and comprised 4,954 stroke and 7,616 CHD events. Based on the high vs. low analyses, combining cohort studies showed no association between soy intake and risk of stroke (SRR 0.92; 95% CI 0.70-1.10; P-heterogeneity = 0.236; I-2 = 29.4%) or CHD (SRR 0.97; 95% CI 0.74-1.27; P-heterogeneity = 0.020; I-2 = 62.7%), although a significantly inverse association between soy intake and the risk of stroke (SRR 0.54; 95% CI 0.34-0.87; P-heterogeneity = 0.001; I-2 = 79.3%) and CHD (SRR 0.66; 95% CI 0.56-0.77; P-heterogeneity 0.421; I-2 = 0) was observed in case-control studies. No association between soy isoflavone intake and the risk of stroke and CHD was identified. Conclusion: There was limited evidence to indicate that soy consumption was inversely associated with the risk of stroke and CHD, although further studies, with prospective designs that use validated questionnaires and control for important confounders, are warranted. (c) 2016 S. Karger AG, Basel
C1 [Lou, Danfei; Li, Yuehua; Yan, Guoliang; Bu, Jianhong; Wang, Haihui] Shanghai Univ Tradit Chinese Med, Shanghai Municipal Hosp Tradit Chinese Med, Dept Geriatr, 274 Zhijiang Zhong Rd, Shanghai 200071, Peoples R China.
C3 Shanghai University of Traditional Chinese Medicine
RP Lou, DF (corresponding author), Shanghai Univ Tradit Chinese Med, Shanghai Municipal Hosp Tradit Chinese Med, Dept Geriatr, 274 Zhijiang Zhong Rd, Shanghai 200071, Peoples R China.
EM louyf7890@163.com
RI Lou, Danfei/ADF-0436-2022
FU National Natural Science Foundation of China [81202664]; Shanghai
   Xinglin New Star Program, Training Program for Potential Medical Experts
   in Shanghai University of TCM [ZY3-RCPY-2-2016]
FX This study was supported by the National Natural Science Foundation of
   China (No. 81202664), and by Shanghai Xinglin New Star Program
   (ZY3-RCPY-2-2016), Training Program for Potential Medical Experts in
   Shanghai University of TCM.
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NR 40
TC 23
Z9 23
U1 1
U2 16
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0251-5350
EI 1423-0208
J9 NEUROEPIDEMIOLOGY
JI Neuroepidemiology
PY 2016
VL 46
IS 4
BP 242
EP 252
DI 10.1159/000444324
PG 11
WC Public, Environmental & Occupational Health; Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health; Neurosciences & Neurology
GA DN1FQ
UT WOS:000376812100004
PM 26974464
DA 2025-06-11
ER

PT J
AU Jiang, QX
   Wang, DY
   Han, YT
   Han, ZW
   Zhong, WZ
   Wang, CB
AF Jiang, Qixiao
   Wang, Daoyan
   Han, Yantao
   Han, Zhiwu
   Zhong, Weizhen
   Wang, Chunbo
TI Modulation of oxidized-LDL receptor-1 (LOX1) contributes to the
   antiatherosclerosis effect of oleanolic acid
SO INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
LA English
DT Article
DE Oleanolic acid; Quails; Antiatherosclerosis; Oxidized low-density
   lipoprotein; LOX-1
ID LOW-DENSITY-LIPOPROTEIN; LECTIN-LIKE; OX-LDL; URSOLIC ACID; METABOLIC
   SYNDROME; ENDOTHELIAL-CELLS; OXIDATIVE STRESS; UP-REGULATION;
   EXPRESSION; APOPTOSIS
AB Oleanolic acid (OA) is a bioactive pentacyclic triterpenoid. The current work studied the effects and possible mechanisms of OA in atherosclerosis. Quails (Cotumix coturnix) were treated with high fat diet with or without OA. Atherosclerosis was assessed by examining lipid profile, antioxidant status and histology in serum and aorta. Human umbilical vein endothelial cells (HUVECs) were exposed to 200 mu g/mL ox-LDL for 24 h, then cell viability was assessed with MTT assay; reactive oxygen species (ROS) was assessed with DCFDA staining. Expression levels of LOX-1, NADPH oxidase subunits, nrf2 and ho-1 were measured with real time PCR and western blotting. Furthermore, LOX-1 was silenced with lentivirus and the expression levels assessment was repeated. OA treatment improved the lipid profile and antioxidant status in quails fed with high fat diet. Histology showed decreased atherosclerosis in OA treated animals. Ox-LDL exposure decreased viability and induced ROS generation in HUVECs, and this progression was alleviated by OA pretreatment. Moreover, elevated expression of LOX-1, NADPH oxidase subunits, nrf2 and ho-1 were observed in ox-LDL exposed HUVECs. OA pretreatment prevented ox-LDL induced increase of LOX-1 and NADPH oxidase subunits expression, while further increased nrf2 and ho-1 expression. Silencing of LOX-1 abolished ox-LDL induced effects in cell viability, ROS generation and gene expression. OA could alleviate high fat diet induced atherosclerosis in quail and ox-LDL induced cytotoxicity in HUVECs; the potential mechanism involves modulation of LOX-1 activity, including inhibition of expression of NADPH oxidase subunits and increase of the expression of nrf2 and ho-1. (C) 2015 Elsevier Ltd. All rights reserved.
C1 [Jiang, Qixiao; Wang, Daoyan; Han, Yantao; Zhong, Weizhen; Wang, Chunbo] Qingdao Univ, Dept Pharmacol, Coll Med, Qingdao 266071, Shandong, Peoples R China.
   [Han, Zhiwu] Qingdao Univ, Affiliated Hosp, Qingdao 266003, Shandong, Peoples R China.
C3 Qingdao University; Qingdao University
RP Wang, CB (corresponding author), Qingdao Univ, Dept Pharmacol, Coll Med, 308 Ningxia Rd, Qingdao 266071, Shandong, Peoples R China.
EM zhiwu1218@126.com; cbwang666@126.com
FU National Natural Science Foundation of China [81173593, 81274126]
FX This study was funded by the National Natural Science Foundation of
   China (Grant Nos. 81173593 and 81274126).
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NR 52
TC 29
Z9 32
U1 1
U2 19
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 1357-2725
EI 1878-5875
J9 INT J BIOCHEM CELL B
JI Int. J. Biochem. Cell Biol.
PD DEC
PY 2015
VL 69
BP 142
EP 152
DI 10.1016/j.biocel.2015.10.023
PG 11
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA CZ3RD
UT WOS:000367020800016
PM 26510581
DA 2025-06-11
ER

PT J
AU Ma, YJ
   Gao, MM
   Liu, DX
AF Ma, Yongjie
   Gao, Mingming
   Liu, Dexi
TI Chlorogenic Acid Improves High Fat Diet-Induced Hepatic Steatosis and
   Insulin Resistance in Mice
SO PHARMACEUTICAL RESEARCH
LA English
DT Article
DE Chlorogenic acid (CGA); Hepatic steatosis; Inflammation; Insulin
   resistance; Obesity
ID PPAR-GAMMA; INDUCED OBESITY; COFFEE CONSUMPTION; OXIDATIVE STRESS;
   GENE-EXPRESSION; CAFFEIC ACID; LIVER; INFLAMMATION; RATS; OVEREXPRESSION
AB Purpose Chlorogenic acid (CGA), the most abundant component in coffee, has exhibited many biological activities. The objective of this study is to assess preventive and therapeutic effects of CGA on obesity and obesity-related liver steatosis and insulin resistance.
   Methods Two sets of experiments were conducted. In set I, 6-week old C57BL/6 mice were fed a regular chow or high-fat diet (HFD) for 15 weeks with twice intra-peritoneal (IP) injection of CGA (100 mg/kg) or DMSO (carrier solution) per week. In set 2, obese mice (average 50 g) were treated by CGA (100 mg/kg, IP, twice weekly) or DMSO for 6 weeks. Body weight, body composition and food intake were monitored. Blood glucose, insulin and lipid levels were measured at end of the study. Hepatic lipid accumulation and glucose homeostasis were evaluated. Additionally, genes involved in lipid metabolism and inflammation were analyzed by real time PCR.
   Results CGA significantly blocked the development of diet-induced obesity but did not affect body weight in obese mice. CGA treatment curbed HFD-induced hepatic steatosis and insulin resistance. Quantitative PCR analysis shows that CGA treatment suppressed hepatic expression of Ppar gamma, Cd36, Fabp4, and Mgot I gene. CGA treatment also attenuated inflammation in the liver and white adipose tissue accompanied by a decrease in mRNA levels of macrophage marker genes including F4/80, Cd68, Cd11b, Cd11c, and Tnf alpha, Mcp-1 and Ccr2 encoding inflammatory proteins.
   Conclusion Our study provides direct evidence in support of CGA as a potent compound in preventing diet-induced obesity and obesity-related metabolic syndrome. Our results suggest that drinking coffee is beneficial in maintaining metabolic homeostasis when on a high fat diet.
C1 [Ma, Yongjie; Gao, Mingming; Liu, Dexi] Univ Georgia, Coll Pharm, Dept Pharmaceut & Biomed Sci, Athens, GA 30602 USA.
C3 University System of Georgia; University of Georgia
RP Liu, DX (corresponding author), Univ Georgia, Coll Pharm, Dept Pharmaceut & Biomed Sci, Room 450 Pharm South,250 West Green St, Athens, GA 30602 USA.
EM dliu@uga.edu
RI Gao, Mingming/F-4317-2016; MA, YONGJIE/O-3861-2015
FU National Institute of Health [RO1EB007357, RO1HL098295]
FX This work was supported in part by the National Institute of Health
   (RO1EB007357 and RO1HL098295). We thank Ms. Ryan Fugett for
   proof-reading and English editing.
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NR 40
TC 165
Z9 174
U1 1
U2 57
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0724-8741
EI 1573-904X
J9 PHARM RES-DORDR
JI Pharm. Res.
PD APR
PY 2015
VL 32
IS 4
BP 1200
EP 1209
DI 10.1007/s11095-014-1526-9
PG 10
WC Chemistry, Multidisciplinary; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Pharmacology & Pharmacy
GA CD6AG
UT WOS:000351169800003
PM 25248334
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Shawky, NM
   Shehatou, GSG
   Rahim, MA
   Suddek, GM
   Gameil, NM
AF Shawky, Noha M.
   Shehatou, George S. G.
   Rahim, Mona Abdel
   Suddek, Ghada M.
   Gameil, Nariman M.
TI Levocetirizine ameliorates high fructose diet-induced insulin
   resistance, vascular dysfunction and hepatic steatosis in rats
SO EUROPEAN JOURNAL OF PHARMACOLOGY
LA English
DT Article
DE Levocetirizine; Insulin resistance; Lipid profile; Oxidative stress;
   Aortic rings
ID DENSITY-LIPOPROTEIN CHOLESTEROL; TYPE-2 DIABETES-MELLITUS;
   SPRAGUE-DAWLEY RATS; NITRIC-OXIDE; METABOLIC SYNDROME; ENDOTHELIAL
   DYSFUNCTION; CARDIOVASCULAR-DISEASE; GLUCOSE-TOLERANCE; ALLERGIC
   RHINITIS; FEMALE RATS
AB This study investigates the possible protective effects of levocetirizine against fructose-induced insulin resistance, hepatic steatosis and vascular dysfunction, in comparison to pioglitazone, a standard insulin sensitizer. Male Sprague Dawley rats (150-200 g) were divided into 4 groups. Three groups were fed on high fructose diets (RED) containing 60% w/w fructose, while the fourth control group was fed on standard laboratory food for 8 weeks. AUC(OGTT), AUC(ITT), fasting glucose, HOMA-IR, hepatic glutathione (GSH) and malondialdehyde (MDA) levels, serum total cholesterol, LDL-C, C-reactive protein (CRP) level and lactate dehydrogenase (LDH) activity and liver steatosis scores were significantly higher in HFD group compared to control group. Moreover, body weight gain, food intake, feeding efficiency, HOMA-beta, E-max and pEC(50) of acetylcholine-induced relaxations of aortic rings and hepatic superoxide dismutase (SOD) activity were significantly lower in HFD group than in control group. Treatment with levocetirizine caused significant decreases in AUC(OGTT), AUC(ITT), HOMA-IR, hepatic GSH and MDA levels and serum CRP level and LDH activity and significant increases in hepatic SOD activity and HOMA-beta when compared with the RFD group. Although levocetirizine failed to alter TC and LDL-C levels, it produced a significant increase in HDL-C level relative to control group. Levocetirizine was also able to improve acetylcholine-induced relaxations of aortic rings, indicating a protective effect against insulin resistance-induced endothelial damage comparable to that offered by pioglitazone. Moreover, levocetirizine substantially attenuated insulin resistance-associated liver macrovesicular steatosis. These findings demonstrate that levocetirizine ameliorates insulin resistance, improves glucose tolerance and attenuates insulin resistance-linked hepatic steatosis and vascular damage. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Shawky, Noha M.; Shehatou, George S. G.; Suddek, Ghada M.; Gameil, Nariman M.] Mansoura Univ, Fac Pharm, Dept Pharmacol & Toxicol, Mansoura 35516, Egypt.
   [Rahim, Mona Abdel] Mansoura Univ, Fac Med, Urol & Nephrol Ctr, Mansoura 35516, Egypt.
C3 Egyptian Knowledge Bank (EKB); Mansoura University; Egyptian Knowledge
   Bank (EKB); Mansoura University
RP Shehatou, GSG (corresponding author), Mansoura Univ, Fac Pharm, Dept Pharmacol & Toxicol, Mansoura 35516, Egypt.
EM georgeshehatou@gmail.com
RI Suddek, Ghada/HPE-4718-2023; abdrahim, mona/Q-3130-2018; Shawky,
   noha/AAO-9722-2021; Shehatou, George/P-3123-2018
OI rahim, mona/0000-0002-9235-7722; Suddek, Ghada/0000-0002-3283-9471;
   Shehatou, George/0000-0001-5501-1004
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NR 76
TC 31
Z9 33
U1 0
U2 36
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0014-2999
EI 1879-0712
J9 EUR J PHARMACOL
JI Eur. J. Pharmacol.
PD OCT 5
PY 2014
VL 740
BP 353
EP 363
DI 10.1016/j.ejphar.2014.07.021
PG 11
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA AO2OH
UT WOS:000341163700044
PM 25064340
DA 2025-06-11
ER

PT J
AU Kumari, M
   Chandola, T
   Brunner, E
   Kivimaki, M
AF Kumari, Meena
   Chandola, Tarani
   Brunner, Eric
   Kivimaki, Mika
TI A Nonlinear Relationship of Generalized and Central Obesity with Diurnal
   Cortisol Secretion in the Whitehall II Study
SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Article
ID PITUITARY-ADRENAL AXIS; 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1;
   ABDOMINAL OBESITY; WAIST CIRCUMFERENCE; METABOLIC SYNDROME; MEN; STRESS;
   WOMEN; ABNORMALITIES; ADIPOSITY
AB Context: Evidence for an association of measures of generalized and central obesity with salivary cortisol secretion is equivocal.
   Objective: The objective of this study was to assess the relationship between body mass index (BMI), waist circumference, and salivary cortisol.
   Design: The design was a cross-sectional study of BMI, waist circumference, and salivary cortisol from phase 7 (2002-2004) of the Whitehall II study.
   Setting: The occupational cohort was originally recruited in 1985-1988.
   Participants: Participants included 2915 men and 1041 women aged 50-74 yr with complete information on height, weight and waist circumference, and cortisol secretion.
   Outcome Measures: Saliva samples were taken on waking, waking plus 0.5, 2.5, 8, and 12 h, and bedtime for the assessment of cortisol. The cortisol awakening response and slope in diurnal secretion were calculated.
   Results: After adjustment for age, sex, social position, waking time, and time since waking of sample collection, increasing central and generalized obesity was associated with lower waking cortisol (P = 0.001). U-shaped associations were apparent between diurnal slope in salivary cortisol and both BMI and waist circumference (P < 0.0001 for quadratic term). For example, the shallowest (most adverse) slopes in salivary cortisol were associated with highest (> 31 kg/m(2)) and lowest (< 21 kg/m2) levels of BMI, and the steepest slopes were apparent for those with BMI of 26 kg/m2, independently of the 12 covariates examined. No associations were apparent for the cortisol awakening response (P > 0.05).
   Conclusion: The associations of measures of generalized and central obesity with diurnal slope in salivary cortisol are not linear in older adults. These nonlinear associations may explain previously described mixed findings. (J Clin Endocrinol Metab 95: 4415-4423, 2010)
C1 [Kumari, Meena; Chandola, Tarani; Brunner, Eric; Kivimaki, Mika] Dept Epidemiol & Publ Hlth, London WC1E 6BT, England.
RP Kumari, M (corresponding author), Dept Epidemiol & Publ Hlth, 2-16 Torrington Pl, London WC1E 6BT, England.
EM m.kumari@ucl.ac.uk
RI Brunner, Eric/H-2114-2011; Kivimaki, Mika/B-3607-2012; Chandola,
   Tarani/I-3192-2013
OI Chandola, Tarani/0000-0002-1864-3413; Kivimaki,
   Mika/0000-0002-4699-5627; Kumari, Meena/0000-0001-9716-1035; Brunner,
   Eric/0000-0002-0595-4474
FU Medical Research Council; Economic and Social Research Council; British
   Heart Foundation; Health and Safety Executive; Department of Health;
   National Heart Lung and Blood Institute/National Institutes of Health
   (NIH); National Institute on Aging/NIH; John D. and Catherine T.
   MacArthur Foundation Research Networks on Successful Midlife Development
   and Socio-Economic Status and Health and Agency for Health Care Policy
   Research [HS06516]; Academy of Finland and the Bupa Foundation; Medical
   Research Council (MRC); Economic and Social Research Council [RES
   596-28-0001]; MRC, Economic and Social Research Council [RES
   596-28-0001]; National Heart Lung and Blood Institute [HL36310]; MRC
   [G0902037] Funding Source: UKRI
FX The Whitehall II study has been supported by grants from the Medical
   Research Council, the Economic and Social Research Council, the British
   Heart Foundation, the Health and Safety Executive, the Department of
   Health, the National Heart Lung and Blood Institute/National Institutes
   of Health (NIH), the National Institute on Aging/NIH, and the John D.
   and Catherine T. MacArthur Foundation Research Networks on Successful
   Midlife Development and Socio-Economic Status and Health and Agency for
   Health Care Policy Research Grant HS06516. M. Ki is supported by Academy
   of Finland and the Bupa Foundation. T. C. is supported by the Medical
   Research Council (MRC) and Economic and Social Research Council Grant
   RES 596-28-0001. M. Ku was partially supported by MRC, Economic and
   Social Research Council Grant RES 596-28-0001, and National Heart Lung
   and Blood Institute Grant HL36310.
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NR 40
TC 115
Z9 125
U1 0
U2 14
PU ENDOCRINE SOC
PI CHEVY CHASE
PA 8401 CONNECTICUT AVE, SUITE 900, CHEVY CHASE, MD 20815-5817 USA
SN 0021-972X
J9 J CLIN ENDOCR METAB
JI J. Clin. Endocrinol. Metab.
PD SEP
PY 2010
VL 95
IS 9
BP 4415
EP 4423
DI 10.1210/jc.2009-2105
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 647SU
UT WOS:000281640300059
PM 20591984
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Choi, SS
   Diehl, AM
AF Choi, Steve S.
   Diehl, Anna Mae
TI Hepatic triglyceride synthesis and nonalcoholic fatty liver disease
SO CURRENT OPINION IN LIPIDOLOGY
LA English
DT Review
DE acyl-CoA : diacylglycerol acyltransferase; antisense oligonucleotide;
   fibrosis; lipotoxicity; nonalcoholic fatty liver disease; triglycerides
ID INSULIN-RESISTANCE; STELLATE CELLS; DIACYLGLYCEROL ACYLTRANSFERASE;
   METABOLIC SYNDROME; ADIPOSE-TISSUE; ANIMAL-MODELS; OBESE MICE;
   TNF-ALPHA; STEATOSIS; STEATOHEPATITIS
AB Purpose of review
   Nonalcoholic fatty liver disease is a spectrum of diseases ranging from simple steatosis to cirrhosis. The hallmark of nonalcoholic fatty liver disease is hepatocyte accumulation of triglycerides. We will review the role of triglyceride synthesis in nonalcoholic fatty liver disease progression and summarize recent findings about triglyceride synthesis inhibition and prevention of progressive disease.
   Recent findings
   Attempts to inhibit triglyceride synthesis in animal models have resulted in improvement in hepatic steatosis. Studies in animal models of nonalcoholic fatty liver disease demonstrate that inhibition of acyl-coenzyme A:diacylglycerol acyltransferase, the enzyme that catalyzes the final step in triglyceride synthesis, results in improvement in hepatic steatosis and insulin sensitivity. We recently confirmed that hepatic specific inhibition of acyl-coenzyme A:diacylglycerol acyltransferase with antisense oligonucleotides improves hepatic steatosis in obese, diabetic mice but, unexpectedly, exacerbated injury and fibrosis in that model of progressive nonalcoholic fatty liver disease. When hepatocyte triglyceride synthesis was inhibited, free fatty acids accumulated in the liver, leading to induction of fatty acid oxidizing systems that increased hepatic oxidative stress and liver damage. These findings suggest that the ability to synthesize triglycerides may, in fact, be protective in obesity.
   Summary
   Nonalcoholic fatty liver disease is strongly associated with obesity and peripheral insulin resistance. Peripheral insulin resistance increases lipolysis in adipose depots, promoting increased free fatty acid delivery to the liver. In states of energy excess, such as obesity, the latter normally triggers hepatic triglyceride synthesis. When hepatic triglyceride synthesis is unable to accommodate increased hepatocyte free fatty acid accumulation, however, lipotoxicity results. Thus, rather than being hepatotoxic, liver triglyceride accumulation is actually hepato-protective in obese, insulin-resistant individuals.
C1 [Choi, Steve S.; Diehl, Anna Mae] Duke Univ, Med Ctr, Div Gastroenterol, Dept Med, Durham, NC 27710 USA.
   [Choi, Steve S.] Vet Affairs Med Ctr, Dept Med, Gastroenterol Sect, Durham, NC USA.
C3 Duke University; US Department of Veterans Affairs; Veterans Health
   Administration (VHA)
RP Diehl, AM (corresponding author), Duke Univ, Med Ctr, Div Gastroenterol, Dept Med, Genome Sci Res Bldg-1,595 LaSalle St,Suite 1073,D, Durham, NC 27710 USA.
EM annamae.diehl@duke.edu
RI Choi, Steve/GZH-1598-2022
FU NIDDK NIH HHS [R01 DK53792] Funding Source: Medline
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NR 44
TC 202
Z9 222
U1 1
U2 50
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0957-9672
EI 1473-6535
J9 CURR OPIN LIPIDOL
JI Curr. Opin. Lipidology
PD JUN
PY 2008
VL 19
IS 3
BP 295
EP 300
DI 10.1097/MOL.0b013e3282ff5e55
PG 6
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism; Peripheral
   Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism;
   Cardiovascular System & Cardiology
GA 307CS
UT WOS:000256296000012
PM 18460922
DA 2025-06-11
ER

PT J
AU Doi, Y
   Kubo, M
   Yonemoto, K
   Ninomiya, T
   Iwase, M
   Tanizaki, Y
   Shikata, K
   Iida, M
   Kiyohara, Y
AF Doi, Yasufumi
   Kubo, Michiaki
   Yonemoto, Koji
   Ninomiya, Toshiharu
   Iwase, Masanori
   Tanizaki, Yumihiro
   Shikata, Kentaro
   Iida, Mitsuo
   Kiyohara, Yutaka
TI Liver enzymes as a predictor for incident diabetes in a Japanese
   population: The Hisayama study
SO OBESITY
LA English
DT Article
DE liver; longitudinal; C-reactive protein; diabetes; visceral obesity
ID GAMMA-GLUTAMYL-TRANSFERASE; C-REACTIVE PROTEIN; INSULIN-RESISTANCE;
   METABOLIC SYNDROME; ALANINE AMINOTRANSFERASE; FOLLOW-UP;
   GLUCOSE-TOLERANCE; OXIDATIVE STRESS; RISK-FACTORS; MEN
AB Objective: We studied the relationship between liver enzymes and the development of diabetes in a general Japanese population.
   Research Methods and Procedures: A total of 1804 nondiabetic subjects 40 to 79 years of age were followed-up prospectively for a mean of 9.0 years.
   Results: During the follow-up, 135 subjects developed diabetes. In both sexes, the age-adjusted cumulative incidence of diabetes increased significantly with elevating quartiles of serum gamma-glutamyltransferase (GGT) and alanine aminotransferase (ALT) levels. This pattern was also observed in aspartate aminotransferase (AST) quartiles for men but not for women. In multivariate analyses after adjusting for comprehensive risk factors and other liver enzymes, the risk of developing diabetes was significantly higher in the highest GGT quartile than in the lowest quartile [odds ratio (OR), 2.54; 95% confidence interval (CI), 1.03 to 6.26 for men; OR, 5.73; 95% CI, 1.62 to 20.19 for women]. Similar results were observed in ALT quartiles (OR, 2.32; 95% CI, 0.91 to 5.92 for men; OR, 4.40; 95% CI, 1.38 to 14.06 for women) but not in AST quartiles in either sex. Significant positive associations of GGT and ALT with diabetes were seen within each stratified category of risk factors, namely fasting insulin, BMI, waist-to-hip ratio, high-sensitivity C-reactive protein, and alcohol consumption. In receiver operating characteristic analyses, the areas under the receiver operating characteristic curve of GGT and ALT were significantly larger than that of AST, fasting insulin, waist-tohip ratio, or C-reactive protein.
   Discussion: Our findings suggest that serum GGT and ALT concentrations are strong predictors of diabetes in the general population, independent of known risk factors.
C1 Kyushu Univ, Grad Sch Med Sci, Dept Med & Clin Sci, Higashi Ku, Fukuoka 8128582, Japan.
   Kyushu Univ, Grad Sch Med Sci, Dept Environm Med, Fukuoka 8128582, Japan.
C3 Kyushu University; Kyushu University
RP Doi, Y (corresponding author), Kyushu Univ, Grad Sch Med Sci, Dept Med & Clin Sci, Higashi Ku, Maidashi 3-1-1, Fukuoka 8128582, Japan.
EM doi@inimed2.med.kyushu-u.ac.jp
RI Kubo, Michiaki/N-7947-2015; Navarrete-Muñoz, Eva/F-1666-2011
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NR 31
TC 108
Z9 123
U1 0
U2 6
PU NORTH AMER ASSOC STUDY OBESITY
PI SILVER SPRING
PA 8630 FENTON ST, SUITE 918, SILVER SPRING, MD 20910 USA
SN 1930-7381
J9 OBESITY
JI Obesity
PD JUL
PY 2007
VL 15
IS 7
BP 1841
EP 1850
DI 10.1038/oby.2007.218
PG 10
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 192ZO
UT WOS:000248242900026
PM 17636103
OA Bronze
DA 2025-06-11
ER

PT J
AU Longo, GZ
   Ordaz, KD
   da Silva, DCG
   Hinnig, PD
   Roberto, DMT
   Reinert, C
   Pot, GK
   Palla, L
AF Longo, Giana Zarbato
   Ordaz, Karla Diaz
   Guimaraes da Silva, Danielle Cristina
   Hinnig, Patricia de Fragas
   Teixeira Roberto, Denise Miguel
   Reinert, Camile
   Pot, Gerda K.
   Palla, Luigi
TI Dietary patterns and cardiovascular risk factors among Brazilians: A
   population-based study in Vicedilcosa, Minas Gerais
SO NUTRITION
LA English
DT Article
DE Dietary pattern; Cardiovascular risk; Adults; Nutrition epidemiology;
   Cross-sectional; Cytokines; Oxidative stress
ID C-REACTIVE PROTEIN; BODY-MASS INDEX; METABOLIC SYNDROME; FATTY-ACIDS;
   MEDITERRANEAN DIET; BLOOD-PRESSURE; SYSTEMIC INFLAMMATION; WAIST
   CIRCUMFERENCE; INSULIN-RESISTANCE; EATING PATTERNS
AB Objective: The aim of this study was to identify dietary patterns (DPs) and analyze their association with cardiovascular risk factors including metabolic biomarkers and markers of inflammation and oxidative stress in a cross-sectional population-based study with 959 Brazilian adults from Vicosa.
   Methods: Food consumption was assessed by food frequency questionnaire, and DPs were identified by principal component analysis. A self-administered questionnaire was applied to assess sociodemographic and behavioral variables.
   Results: Four distinct DPs were identified: Western, Snacks and Processed Food, Healthy, and Traditional Brazilian. Comparing the highest to the lowest tertile of each DP: Snacks and Processed Food DP was associated with a significantly higher diastolic blood pressure (beta = 2.81; 95% confidence interval [CI], 0.48-5.14), waist circumference (beta = 4.75; 95% CI, 2.77-6.73), body mass index (beta = 1.65; 95% CI, 0.63-2.67), neck circumference (beta = 0.74; 95% CI, 0.15-1.34), uric acid (beta = 0.32; 95% CI, 0.13-0.51), and C-reactive protein (beta = 0.31; 95% CI, 0.07-0.55). The Healthy DP was associated with lower Homeostatic Model Assessment of Insulin Resistance (HOMA-IR; beta = -0.17; 95% CI, -0.34 to -0.008), lower tumor necrosis factor-alpha (odds ratio [OR] = 0.46; 95% CI, 0.26-0.84), lower interleukin (IL)-8 (OR = 0.50; 95% CI, 0.28-0.91), and lower catalase (OR = 0.36; 95% CI, 0.16-0.78). The Traditional Brazilian DP was associated with lower high-density lipoprotein (HDL) cholesterol (beta = -5.04; 95% CI, -7.60 to -2.48), non-HDL cholesterol (beta: -10.25; 95% CI, -19.07 to -1.43), and superoxide dismutase (OR = 0.52; 95% CI, 0.32-0.87), and higher uric acid (beta = 0.24; 95% CI, 0.01-0.48), IL-12p70 (OR = 2.55; 95% CI, 1.23-5.32), IL-1 beta (OR = 2.22; 95% CI, 1.01-4.89), IL-10 (OR = 2.03; 95% CI, 1.05-3.93), and ferric reducing ability of plasma (OR = 2.23; 95% CI, 1.16-4.27).
   Conclusions: The Snacks and Processed Food DP was associated with increases in several risk factors for cardiovascular disease, and the Healthy DP with lower HOMA-IR scores, tumor necrosis factor-alpha, IL-8, and catalase. A diet based on rice and beans (Traditional Brazilian) may have a protective role against non-HDL cholesterol while presenting other risks related to inflammation and oxidative stress, as shown by a direct association with the interleukins IL-12p70, IL-1 beta, and IL-10 and an inverse association with superoxide dismutase. (C) 2022 Elsevier Inc. All rights reserved.
C1 [Longo, Giana Zarbato; Hinnig, Patricia de Fragas; Teixeira Roberto, Denise Miguel; Reinert, Camile] Univ Fed Santa Catarina, Dept Nutr, Florianopolis, SC, Brazil.
   [Ordaz, Karla Diaz; Palla, Luigi] London Sch Hyg & Trop Med, Fac Epidemiol & Populat Hlth, London, England.
   [Guimaraes da Silva, Danielle Cristina] Fed Univ Western Bahia, Barreiras, Brazil.
   [Pot, Gerda K.] Kings Coll London, Diabet & Nutr Sci Div, London, England.
   [Palla, Luigi] Univ Roma La Sapienza, Dept Publ Hlth & Infect Dis, Rome, Italy.
C3 Universidade Federal de Santa Catarina (UFSC); University of London;
   London School of Hygiene & Tropical Medicine; Universidade Federal do
   Oeste da Bahia; University of London; King's College London; Sapienza
   University Rome
RP Longo, GZ (corresponding author), Univ Fed Santa Catarina, Dept Nutr, Florianopolis, SC, Brazil.; Palla, L (corresponding author), London Sch Hyg & Trop Med, Fac Epidemiol & Populat Hlth, London, England.; Palla, L (corresponding author), Univ Roma La Sapienza, Dept Publ Hlth & Infect Dis, Rome, Italy.
EM giana.zarbato@gmail.com; luigi.palla@uniroma1.it
RI da Silva de Oliveira, Danielle/O-5548-2015; LONGO, GIANA/AAX-6501-2020;
   Roberto, Denise/HFZ-8971-2022; Hinnig, Patricia/Q-4262-2018
OI Miguel Teixeira Roberto, Denise/0000-0003-2234-7323;
   /0000-0001-7666-5007; DiazOrdaz, Karla/0000-0003-3155-1561
FU National Council for Scientific and Technological Development (CNPq)
   [481418/2011-3]; Research Support Foundation of the State of Minas
   Gerais (FAPEMIG) [APQ-00296-12]; Brazilian Federal Agency for the
   Improvement of Higher Education (CAPES); BIOCLIN
FX This research received financial support from the National Council for
   Scientific and Technological Development (CNPq process 481418/2011-3),
   the Research Support Foundation of the State of Minas Gerais (FAPEMIG
   process APQ-00296-12) and BIOCLIN. G. Z. L received a fellowship from
   the Brazilian Federal Agency for the Improvement of Higher Education
   (CAPES).
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NR 97
TC 2
Z9 2
U1 0
U2 6
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0899-9007
EI 1873-1244
J9 NUTRITION
JI Nutrition
PD JUN
PY 2022
VL 98
AR 111626
DI 10.1016/j.nut.2022.111626
EA APR 2022
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 2R4FH
UT WOS:000821067700003
PM 35397386
DA 2025-06-11
ER

PT J
AU Cai, YT
   Zijlema, WL
   Sorgjerd, EP
   Doiron, D
   de Hoogh, K
   Hodgson, S
   Wolffenbuttel, B
   Gulliver, J
   Hansell, AL
   Nieuwenhuijsen, M
   Rahimi, K
   Kvaloy, K
AF Cai, Yutong
   Zijlema, Wilma L.
   Sorgjerd, Elin Pettersen
   Doiron, Dany
   de Hoogh, Kees
   Hodgson, Susan
   Wolffenbuttel, Bruce
   Gulliver, John
   Hansell, Anna L.
   Nieuwenhuijsen, Mark
   Rahimi, Kazem
   Kvaloy, Kirsti
TI Impact of road traffic noise on obesity measures: Observational study of
   three European cohorts
SO ENVIRONMENTAL RESEARCH
LA English
DT Article
DE Noise; Traffic; Central obesity; Pollution; Cardiometabolic risk; Body
   mass index
ID LONG-TERM EXPOSURE; TRANSPORTATION NOISE; AIR-POLLUTION; ASSOCIATION;
   MARKERS; ADIPOSITY; HUNT; NO2
AB Background: Environmental stressors such as transport noise may contribute to development of obesity through increased levels of stress hormones, sleep deprivation and endocrine disruption. Epidemiological evidence supporting an association of road traffic noise with obesity markers is still relatively scant and confined to certain geographical regions. We aimed to examine the cross-sectional associations between road traffic noise and obesity markers in three large European cohorts involving nearly 500,000 individuals.
   Methods: Three population-based cohorts (UK Biobank, Lifelines, HUNT3) were established between 2006 and 2013 in the UK, the Netherlands and Norway respectively. For all three cohorts, residential 24-h road traffic noise (Lden) for 2009 was modelled from a standardised European noise assessment framework. Residential exposures to NO2 for 2007 and PM2.5 for 2010 were estimated from Europe-wide land use regression models. Obesity markers including body mass index and waist circumference were measured at recruitment. Obesity and central obesity status were subsequently derived. Regression models were fitted in each cohort, adjusting for a harmonised set of demographic and lifestyle covariates, with further adjustments for air pollution in the main model.
   Results: The main analyses included 412,934 participants of UK Biobank, 61,032 of Lifelines and 30,305 of HUNT3, with a mean age of 43-56 years and Lden ranging 42-89 dB(A) across cohorts. In UK Biobank, per 10 dB (A) higher of Lden: BMI was higher by 0.14kg/m2 (95%CI: 0.11-0.18), waist circumference higher by 0.27 cm (95%CI: 0.19-0.35), odds of obesity was 1.06 (95%CI: 1.04-1.08) and of central obesity was 1.05 (95%CI: 1.04-1.07). These associations were robust to most other sensitivity analyses but attenuated by further adjustment of PM2.5 or area-level socioeconomic status. Associations were more pronounced among women, those with low physical activity, higher household income or hearing impairment. In HUNT3, associations were observed for obesity or central obesity status among those exposed to Lden greater than 55 dB(A). In contrast, no or negative associations were observed in the Lifelines cohort.
   Conclusions: This largest study to date providing mixed findings on impacts of long-term exposure to road traffic noise on obesity, which necessitates future analyses using longitudinal data to further investigate this potentially important epidemiological link.
C1 [Cai, Yutong; Rahimi, Kazem] Univ Oxford, Nuffield Dept Womens & Reprod Hlth, Oxford OX3 9DU, England.
   [Cai, Yutong; Rahimi, Kazem] Univ Oxford, Oxford Martin Sch, Deep Med Programme, Oxford, England.
   [Cai, Yutong; Hodgson, Susan] Imperial Coll London, MRC Ctr Environm & Hlth, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England.
   [Zijlema, Wilma L.; Nieuwenhuijsen, Mark] Barcelona Inst Global Hlth ISGlobal, Barcelona, Catalonia, Spain.
   [Zijlema, Wilma L.; Nieuwenhuijsen, Mark] Univ Pompeu Fabra UPF, Barcelona, Catalonia, Spain.
   [Zijlema, Wilma L.; Nieuwenhuijsen, Mark] CIBER Epidemiol & Salud Publ CIBERESP, Barcelona, Catalonia, Spain.
   [Sorgjerd, Elin Pettersen; Kvaloy, Kirsti] Norwegian Univ Sci & Technol, HUNT Res Ctr, Dept Publ Hlth & Nursing, Levanger, Norway.
   [Sorgjerd, Elin Pettersen] Trondheim Reg & Univ Hosp, St Olavs Hosp, Dept Endocrinol, Trondheim, Norway.
   [Doiron, Dany] McGill Univ, Res Inst, Hlth Ctr, Montreal, PQ, Canada.
   [de Hoogh, Kees] Swiss Trop & Publ Hlth Inst, Basel, Switzerland.
   [de Hoogh, Kees] Univ Basel, Basel, Switzerland.
   [Wolffenbuttel, Bruce] Univ Groningen, Univ Med Ctr Groningen, Dept Endocrinol, Groningen, Netherlands.
   [Gulliver, John; Hansell, Anna L.] Univ Leicester, Ctr Environm Hlth & Sustainabil, Leicester, Leics, England.
   [Kvaloy, Kirsti] Nord Trondelag Hosp Trust, Levanger Hosp, Dept Res & Dev, Levanger, Norway.
C3 University of Oxford; University of Oxford; Imperial College London;
   ISGlobal; Pompeu Fabra University; CIBER - Centro de Investigacion
   Biomedica en Red; CIBERESP; Norwegian University of Science & Technology
   (NTNU); Norwegian University of Science & Technology (NTNU); McGill
   University; Swiss School of Public Health (SSPH+); University of Basel;
   Swiss Tropical & Public Health Institute; University of Basel;
   University of Groningen; University of Leicester
RP Cai, YT (corresponding author), Univ Oxford, Nuffield Dept Womens & Reprod Hlth, Oxford OX3 9DU, England.
EM yutong.cai@wrh.ox.ac.uk
RI Hodgson, Susan/H-1317-2013; de Hoogh, Kees/ABE-1274-2021; Zijlema,
   Wilma/AAE-2409-2021; Rahimi, Kazem/AAA-4250-2022; Nieuwenhuijsen,
   Mark/C-3914-2017; Rahimi, Kazem/Q-1279-2015
OI Gulliver, John/0000-0003-3423-2013; Kvaloy, Kirsti/0000-0002-8038-917X;
   Cai, Yutong/0000-0003-1601-2199; Nieuwenhuijsen,
   Mark/0000-0001-9461-7981; Wolffenbuttel, Bruce H.R./0000-0001-9262-6921;
   Hansell, Anna/0000-0001-9904-7447; Rahimi, Kazem/0000-0002-4807-4610;
   Hodgson, Susan/0000-0001-8519-8586
FU European Union Seventh Framework Programme (FP7/2007-2013) Biobank
   Standardisation and Harmonisation for Research Excellence in the
   European Union-B ioSHaRE-EU [261433]; Welsh Assembly Government; British
   Heart Foundation; Diabetes UK; Dutch Ministry of Health, Welfare and
   Sport; Dutch Ministry of Economic Affairs; University Medical Centre
   Groningen (UMCG the Netherlands); University Groningen; UK Medical
   Research Council [MR/5019669/1]; MRC early-career research fellowship at
   the MRC centre for Environment and Health [MR/M501669/1]; Instituto de
   Salud Carlos III [CD17/00195]; PEAK Urban programme - UKRI's Global
   Challenge Research Fund [ES/P011055/1]; Northern Provinces of the
   Netherlands; Liaison Committee [90154900, 46056734]; GCRF [ES/P011055/1]
   Funding Source: UKRI; MRC [MR/S019669/1, MR/M501669/1] Funding Source:
   UKRI
FX This research is funded by European Union Seventh Framework Programme
   (FP7/2007-2013) Biobank Standardisation and Harmonisation for Research
   Excellence in the European Union-B ioSHaRE-EU (Grant Number 261433). UK
   Biobank was established by the Wellcome Trust medical charity, Medical
   Research Council, Department of Health, Scottish Government and the
   Northwest Regional Development Agency. It has also had funding from the
   Welsh Assembly Government, British Heart Foundation and Diabetes UK. The
   Lifelines Biobank initiative has been made possible by subsidy from the
   Dutch Ministry of Health, Welfare and Sport, the Dutch Ministry of
   Economic Affairs, the University Medical Centre Groningen (UMCG the
   Netherlands), University Groningen and the Northern Provinces of the
   Netherlands. The MRC Centre for Environment and Health is funded by the
   UK Medical Research Council (Grant number: MR/5019669/1). Y.0
   acknowledges support from a MRC early-career research fellowship (Grant
   number: MR/M501669/1) at the MRC centre for Environment and Health; W.L.
   Zijlema is supported by a Sara Sorrell grant from the Instituto de Salud
   Carlos III (CD17/00195); E.P. Sorgjerd and K. Kvaloy was supported by
   Liaison Committee between the Central Norway Regional Health Authority
   (RHA) and the Norwegian University of Science and Technology (NTNU)
   (grant 90154900 and 46056734). This article was completed with support
   for Y.C from the PEAK Urban programme, funded by UKRI's Global Challenge
   Research Fund (Grant number: ES/P011055/1).
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NR 42
TC 36
Z9 38
U1 2
U2 23
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0013-9351
EI 1096-0953
J9 ENVIRON RES
JI Environ. Res.
PD DEC
PY 2020
VL 191
AR 110013
DI 10.1016/j.envres.2020.110013
PG 9
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA OP3GW
UT WOS:000587971600016
PM 32805247
OA Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Oriolli, M
   Aldini, G
   Benfatto, MC
   Facino, RM
   Carini, M
AF Oriolli, Marica
   Aldini, Giancarlo
   Benfatto, Maria Carmela
   Facino, Roberto Maffei
   Carini, Marina
TI HNE Michael adducts to histidine and histidine-containing peptides as
   biomarkers of lipid-derived carbonyl stress in urines: LC-MS/NIS
   profiling in Zucker obese rats
SO ANALYTICAL CHEMISTRY
LA English
DT Article
ID TANDEM MASS-SPECTROMETRY; DIHYDROXYNONENE MERCAPTURIC ACID;
   N-EPSILON-CARBOXYMETHYLLYSINE; HUMAN SERUM-ALBUMIN; PEROXIDATION
   PRODUCT; OXIDATIVE STRESS; CHROMATOGRAPHY/MASS SPECTROMETRY;
   ALZHEIMERS-DISEASE; URINARY METABOLITE; COVALENT ADDUCTION
AB A new liquid chromatography-tandem mass spectromettic (LC-MS/MS) approach, based on the precursor ion scanning technique using a triple-stage quadrupole, has been developed to detect free and protein-bound histidine (His) residues modified by reactive carbonyl species (RCS) generated by lipid peroxidation. This approach has been applied to urines from Zucker obese rats, a nondiabetic animal model characterized by obesity and hyperlipidemia, where RCS formation plays a key role in the development of renal and cardiac dysfunction. The immonium ion of His at m/z 110 was used as a specific product ion of His-containing peptides to generate precursor ion spectra, followed by MS2 acquisitions of each precursor ion of interest for structural characterization. By this approach, three novel adducts, which are excreted in free form only, have been identified, two of them originating from the conjugation of 4-hydroxy-trans-2nonenal (HNE) to His, followed by reduction/oxidation of the aldehyde: His-1,4-dihydroxynonane (His-DHN), His-4-hydroxynonanoic acid (His-HNA), and carnosine-HNE, this last recognized in previous in vitro studies as a new potential biomarker of carbonyl stress. No free His-HNE was found in urines, which was detected only in protein hydrolysates. The same LC-MS/MS method, working in multiple reaction monitoring (MRM) mode, has been developed, validated, and applied to quantitatively profile in Zucker urines both conventional (1,4-dihydroxynonane mercapturic acid, DHN-MA) and the newly identified adducts, except His-HNA. The analytes were separated on a C12 reversed-pbase column by gradient elution from 100% A (water containing 5 mM nonafluoropentanoic acid) to 80% B (acetonitrile) in 24 min at a flow rate of 0.2 mL/min and analyzed for quantification in MRM mode by applying the following precursor-to-product ion transitions m/z 322.2 -> 164. 1 + 130.1 (DHN-MA), m/z 314.7 -> 268.2 + 110.1 (His-DHN), m/z 312.2 -> 110.1 + 156.0 (His-HNE), m/z 383.1 -> 266.2 + 110.1 (CAR-HNE), m/z 319.2 -> 301.6 + 156.5 (H-Tyr-His-OH, internal standard). Precision and accuracy data, as well as the lower limits of quantification in urine, were highly satisfactory (from 0.01 nmol/mL for CAR-HNE, His-DHN, His-HNE, to 0.075 nmol/mL for DHN-MA). The method, applied to evaluate for the first time the advanced lipoxidation end products profile in urine from obese Zucker rats, an animal model for the metabolic syndrome, has proved to be suitable and sensitive enough for testing in vivo the carbonyl quenching ability of newly developed RCS sequestering agents.
C1 Univ Milan, Fac Pharm, Ist Chim Farmaceut & Tossicol Pietro Pratesi, I-20133 Milan, Italy.
C3 University of Milan
RP Carini, M (corresponding author), Univ Milan, Fac Pharm, Ist Chim Farmaceut & Tossicol Pietro Pratesi, Via Mangiagalli 25, I-20133 Milan, Italy.
EM marina.carini@unimi.it
RI aldini, giancarlo/C-3533-2013; CARINI, MARINA/D-3084-2015; orioli,
   marica/F-7606-2015
OI CARINI, MARINA/0000-0003-3407-5425; orioli, marica/0000-0003-1558-9551;
   aldini, giancarlo/0000-0002-2355-6744
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NR 65
TC 74
Z9 80
U1 1
U2 26
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0003-2700
J9 ANAL CHEM
JI Anal. Chem.
PD DEC 1
PY 2007
VL 79
IS 23
BP 9174
EP 9184
DI 10.1021/ac7016184
PG 11
WC Chemistry, Analytical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry
GA 236OH
UT WOS:000251311900051
PM 17979257
DA 2025-06-11
ER

PT J
AU Banga, S
   Kumar, V
   Suri, S
   Kaushal, M
   Prasad, R
   Kaur, S
AF Banga, Shareen
   Kumar, Vikas
   Suri, Sheenam
   Kaushal, Manisha
   Prasad, Rasane
   Kaur, Sawinder
TI Nutraceutical Potential of Diet Drinks: A Critical Review on Components,
   Health Effects, and Consumer Safety
SO JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION
LA English
DT Review
DE Diet drinks; market status of diet drinks; consumption pattern of diet
   drinks; composition of diet drinks; health effects of diet drinks;
   regulations related to diet drinks
ID GUARANA PAULLINIA-CUPANA; IMPROVED COGNITIVE PERFORMANCE; KOREAN RED
   GINSENG; PANAX-GINSENG; OXIDATIVE STRESS; BEVERAGE CONSUMPTION;
   BLOOD-PRESSURE; METABOLIC SYNDROME; CAFFEINE CONTENT; SKELETAL-MUSCLE
AB Background: The purpose of this review paper was to explore the components and their respective health effects and safety aspects regarding the consumption of diet drinks (DDs). Methods: A wide variety of the relevant publications (published before 2018) were identified through searching electronic databases (ScienceDirect, PubMed, SciELO, Google Scholar, Springer Link, and ResearchGate) on the basis of different keywords such as diet drink, market status, consumption pattern, composition, health effects, and regulations related to DDs. After the search of suitable literature, 139 papers were screened and reviewed. Results: Numerous brands of DDs have been introduced in the market along with a wide variety of modifications in order to attract the consumers of all age groups along with their respective professions. The major components of DDs are caffeine, taurine, ginseng, guarana, sodium, potassium, and sweeteners that contribute to the good taste, stimulating effect, increased performance and cognitive function, and reduced stress. However, ingestion of DDs over a prolonged course of time can pose multiple deleterious effects, i.e., intoxication, affective disorder, hypertension, reproductive toxicity, and neurological disorders. Consequently, different regulatory bodies of respective countries have formulated and enforced rules and regulations regarding the composition, consumption, labeling, distribution, and sales of DDs. Conclusions: An awareness regarding the components, consumption, and health effects is greatly required in the present era, and authors have tried to fill this gap.Key teaching points Rise in socio-economic status, health awareness and change in dietary lifestyle are the major factors that fuel the demand of diet drinks; which has been witnessed by a drastic increase in the consumption pattern of the diet drinks among young to middle-age adults since last decade. A wide variety of the ingredients are used in the preparation of diet drinks including caffeine, ginseng (Panax ginseng), guarana (Paullinia cupana), taurine, artificial sweeteners, B Vitamins, sodium, potassium etc. Diet drinks are generally served cold and contain high levels of caffeine and other artificial sweeteners; which based on dosage, have been known to be beneficial as well as harmful. These ingredients possess numerous health benefits including anti-hypertensive, anti-oxidant, anti-cancer properties, improved metabolic functions, stress reduction and enhanced endurance, exercise and performance and increased cognitive function. A wide range of the adverse health effects such as nervousness, sleeplessness, behavioral changes, decreased appetite, heart palpitations, nausea, vomiting, dehydration etc. is being possessed by diet drinks upon the ingestion of these drinks over a prolonged course of time. Regulatory bodies should determine the safe limits of all ingredients for different age groups to get maximum health benefits.
C1 [Banga, Shareen; Kumar, Vikas; Suri, Sheenam; Prasad, Rasane; Kaur, Sawinder] Lovely Profess Univ, Sch Agr, Food Technol & Nutr, Phagwara 144411, Punjab, India.
   [Kaushal, Manisha] Dr Yashwant Singh Parmar Univ Hort & Forestry, Dept Food Sci & Technol, Solan, Himachal Prades, India.
C3 Lovely Professional University; Dr. Yashwant Singh Parmar University of
   Horticulture & Forestry
RP Kumar, V (corresponding author), Lovely Profess Univ, Sch Agr, Food Technol & Nutr, Phagwara 144411, Punjab, India.
EM vkchoprafst@rediffmail.com
RI Rasane, Prasad/F-2838-2017; Kaur, Sawinder/N-7801-2018; Kumar,
   Vikas/N-8955-2018
OI Kaur, Dr. Sawinder/0000-0002-4500-1053; Kaushal,
   Manisha/0000-0003-0327-5029
FU School of Agriculture, Lovely Professional University Phagwara, Punjab,
   India
FX The authors are highly grateful to School of Agriculture, Lovely
   Professional University Phagwara, Punjab, India, for providing financial
   assistance and infrastructure for the preparation of this review.
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NR 139
TC 6
Z9 6
U1 2
U2 35
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 0731-5724
EI 1541-1087
J9 J AM COLL NUTR
JI J. Am. Coll. Nutr.
PD APR 2
PY 2020
VL 39
IS 3
BP 272
EP 286
DI 10.1080/07315724.2019.1642811
EA JUL 2019
PG 15
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nutrition & Dietetics
GA LE0UT
UT WOS:000478251700001
PM 31343956
DA 2025-06-11
ER

PT J
AU Yu, S
   Zhang, Y
   Li, MZ
   Xu, H
   Wang, Q
   Song, J
   Lin, P
   Zhang, L
   Liu, Q
   Huang, QX
   Wang, K
   Hou, WK
AF Yu Shan
   Zhang Ying
   Li Mei-zhen
   Xu Hua
   Wang Qian
   Song Jun
   Lin Peng
   Zhang Li
   Liu Qian
   Huang Qing-xian
   Wang Kun
   Hou Wei-kai
TI Chemerin and apelin are positively correlated with inflammation in obese
   type 2 diabetic patients
SO CHINESE MEDICAL JOURNAL
LA English
DT Article
DE type 2 diabetes mellitus; obesity; insulin resistance; chemerin; apelin
ID ADIPOSE-TISSUE; INSULIN-RESISTANCE; METABOLIC SYNDROME; OXIDATIVE
   STRESS; ADIPOKINE; EXPRESSION; MELLITUS; RECEPTOR; MICE
AB Background As two novel adipocytokines, chemerin and apelin play a key role in the pathological process of insulin resistance (IR), glucose metabolism and obesity, researchers have found that the levels of chemerin and apelin changed significantly in type 2 diabetic patients with obesity, however, the underlying mechanism involved remains unclear. The aim of this study was to investigate whether chemerin and apelin play an important role in the pathophysiologic proceeding of diabetes.
   Methods This study enrolled 81 newly diagnosed obese type 2 diabetes mellitus (T2DM) patients (T2DM group, n=81). All the patients were randomly assigned to DM1 group treated with metformin (n=41) and DM2 group treated with pioglitazone (n=40). After hypoglycemic agents treatment, patients under better blood glucose control were chosen to be given antioxidant treatment. Another 79 subjects without T2DM were recruited as normal control group (NC group), including 40 subjects (NC1 group) with normal body mass index (BMI) and 39 obese subjects (NC2 group). Levels of chemerin, apelin, BMI, tumor necrosis factor-alpha (TNF-alpha), homeostasis model assessment of IR (HOMA-IR) and 8-isoprotaglandim F2 alpha (8-iso-PGF2 alpha) were examined at baseline and post-treatment. The relationship between chemerin, apelin and BMI, TNF-alpha, HOMA-IR, 8-iso-PGF2 alpha was analyzed.
   Results The baseline levels of chemerin, apelin, TNF-alpha, HOMA-IR and 8-iso-PGF2 alpha in T2DM group were significantly higher than normal control group (P<0.001). All indices mentioned above were significantly decreased after treatment (P<0.05). In T2DM patients treated with pioglitazone, indices mentioned above except for HOMA-IR, were decreased significantly compared with patients treated with metformin (P<0.05). After antioxidant treatment using lipoic acid, levels of chemerin, apelin, TNF-alpha and 8-iso-PGF2 alpha were further significantly decreased (P<0.05). Correlation analysis showed that the levels of chemerin and apelin correlated positively with BMI, TNF-alpha, HOMA-IR and 8-iso-PGF2 alpha before and after treatment with hypoglycemic agents (P<0.01). The levels of chemerin and apelin also had positive correlation with TNF-alpha and 8-iso-PGF2 alpha after antioxidant treatment (P<0.05).
   Conclusions The levels of chemerin and apelin in obese T2DM patients are closely related to IR. The increased levels may be a result of compensatory response to IR, and also may be the causative factor of IR. The levels of chemerin and apelin correlate closely with oxidative stress and inflammation. The two adipokines may be inflammatory factors playing important roles in the initiation and development of obese T2DM. Chemerin and apelin are related to the pathophysiology of IR, oxidative stress and inflammation. Chin Med J 2012;125(19):3440-3444
C1 [Yu Shan; Song Jun; Lin Peng; Liu Qian; Huang Qing-xian; Wang Kun; Hou Wei-kai] Shandong Univ, Qilu Hosp, Dept Endocrinol, Jinan 250012, Shandong, Peoples R China.
   [Zhang Ying] Rongjun Hosp, Dept Endocrinol, Jinan 250013, Shandong, Peoples R China.
   [Li Mei-zhen] Dongying Peoples Hosp, Dept Endocrinol, Dongying 257091, Shandong, Peoples R China.
   [Xu Hua] Jinan Fifth Hosp, Dept Internal Med, Jinan 250022, Shandong, Peoples R China.
   [Wang Qian] Med Imaging Res Inst, Dept Shandong, Jinan 250001, Shandong, Peoples R China.
   [Zhang Li] Shandong Jiaotong Hosp, Dept Internal Med, Jinan 250031, Shandong, Peoples R China.
C3 Shandong University
RP Hou, WK (corresponding author), Shandong Univ, Qilu Hosp, Dept Endocrinol, Jinan 250012, Shandong, Peoples R China.
EM wkhousdu@yahoo.com.cn
RI Liu, Qian/GZG-3496-2022
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NR 24
TC 54
Z9 62
U1 0
U2 18
PU CHINESE MEDICAL ASSOC
PI BEIJING
PA 42 DONGSI XIDAJIE, BEIJING 100710, PEOPLES R CHINA
SN 0366-6999
J9 CHINESE MED J-PEKING
JI Chin. Med. J.
PD OCT 5
PY 2012
VL 125
IS 19
BP 3440
EP 3444
DI 10.3760/cma.j.issn.0366-6999.2012.19.015
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 039RU
UT WOS:000311265000015
PM 23044303
DA 2025-06-11
ER

PT J
AU Vorobets, MZ
   Vorobets, DZ
   Chaplyk, VV
   Onufrovych, OK
   Besedina, AS
   Fafula, R
   Vorobets, ZD
   Chemerys, OM
AF Vorobets, M. Z.
   Vorobets, D. Z.
   Chaplyk, V. V.
   Onufrovych, O. K.
   Besedina, A. S.
   Fafula, R., V
   Vorobets, Z. D.
   Chemerys, O. M.
TI The diagnostic value of the NO-synthase, Ca<SUP>2+</SUP>- and
   Na<SUP>+</SUP>-dependent ATP-hydrolase systems and the therapeutic
   potential of NO-stimulators in erectile dysfunction of men injured as a
   result of combat operations (combat trauma)
SO REGULATORY MECHANISMS IN BIOSYSTEMS
LA English
DT Article
DE combat trauma; erectile dysfunction; lymphocytes; Na+,K+-ATPase;
   Ca2+,Mg2+-ATPase; arginase; NO-synthase; arginase; NO-synthase
ID POSTTRAUMATIC-STRESS-DISORDER; NITRIC-OXIDE; INHIBITORS; VETERANS
AB Erectile dysfunction (ED), as a sexual disorder, is characterized by persistent inability to achieve and maintain an erection sufficient for satisfactory sexual intercourse. Among the numerous pathological conditions that precede ED or are complicated with it, neurotic disorders, metabolic disorders, blood vessels diseases, partial androgen deficiency, combat injuries, etc. take precedence. An injury is not only a physical, but also a psychological trauma, which is often stretched over some period of time. Post-traumatic stress disorder, depressive states, and post-traumatic chronic pain may develop as a result of a combat wound. These conditions also affect sexual function. The search for sensitive indicators that would reflect both the physiological status of the organism and metabolic changes inside the cell is an urgent issue of modern biochemistry, physiology and medicine in general. This study involved results of examination and treatment of 136 men, participants in hostilities, with sexual dysfunction and leading complaints of erectile dysfunction. The control group consisted of 48 clinically healthy men without complaints of sexual dysfunction or cardiac, neurological or endocrinological pathology. According to the form of ED, patients were divided into groups: patients with psychogenic ED after a combat injury (n = 84) and patients with ED of mixed genesis, which included participants in hostilities with endothelial dysfunction, metabolic syndrome, dyslipidemia, hypertension, coronary heart disease, late hypogonadism (n = 52). It was shown that the development of psychogenic and mixed forms of ED is mostly associated with stress hyperprolactinemia with normal indicators of cavernous dopplerography, lipid metabolism and androgen levels. The Na+,K+-ATPase activity of peripheral blood lymphocytes was significantly decreased in men of different age groups with a mixed form of ED. The Ca2+,Mg2+-ATPase activity of plasma membrane and endoplasmic reticulum decrease was significantly decreased in men with ED of both psychogenic and mixed forms, but a more pronounced decrease was observed with increasing age of patients. Complex treatment of patients with a mixed form of ED with sildenafil leads to a significant increase in Na+,K+-ATPase activity and Ca2+,Mg2+-ATPase activity of endoplasmic reticulum in lymphocytes in patients with ED of mixed genesis. Complex treatment of young age patients with psychogenic ED led to a decrease in the arginase activity in patients with both psychogenic and mixed ED. A decrease in cNOS activity was accompanied by a corresponding increase in iNOS activity in patients with mixed form of ED. Treatment of patients with the use of sildenafil led to non significant increase in cNOS activity in the lymphocytes of patients of both age groups.
C1 [Vorobets, M. Z.; Vorobets, D. Z.; Chaplyk, V. V.; Onufrovych, O. K.; Besedina, A. S.; Fafula, R., V; Vorobets, Z. D.; Chemerys, O. M.] Danylo Halytsky Lviv Natl Med Univ, Pekarska St 69, UA-79010 Lvov, Ukraine.
C3 Danylo Halytsky Lviv National Medical University
RP Vorobets, MZ (corresponding author), Danylo Halytsky Lviv Natl Med Univ, Pekarska St 69, UA-79010 Lvov, Ukraine.
EM vorobetsz@ukr.net
RI Besedina, Anna/H-8222-2018; Onufrovych, Olena/G-5122-2019; Vorobets,
   Zinoviy/G-5932-2019
FU National Research Fund grant "Improvement of diagnosis and treatment of
   disorders of sexual and reproductive functions of men suffered as a
   result of hostilities" [2022.01/0151, 0123U105170]
FX The article was published with the support of the National Research Fund
   grant "Improvement of diagnosis and treatment of disorders of sexual and
   reproductive functions of men suffered as a result of hostilities"
   (registration number 2022.01/0151, state registration number
   0123U105170) .
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NR 49
TC 0
Z9 0
U1 0
U2 0
PU OLES HONCHAR DNIPROPETROVSK NATL UNIV
PI DNIPROPETROVSK
PA PR-KT GAGARINA, 42, DNIPROPETROVSK, 49010, UKRAINE
SN 2519-8521
EI 2520-2588
J9 REGUL MECH BIOSYST
JI Regul. Mech. Biosyst.
PY 2024
VL 15
IS 4
BP 760
EP 766
DI 10.15421/0224110
PG 7
WC Biology
WE Emerging Sources Citation Index (ESCI)
SC Life Sciences & Biomedicine - Other Topics
GA 1PF6Z
UT WOS:001470388500013
OA gold
DA 2025-06-11
ER

PT J
AU Ni, HY
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   Wang, LT
   Zhao, CJ
   Huang, H
   Zhu, HL
   Efferth, T
   Gu, CB
   Fu, YJ
AF Ni, Hai-Yan
   Yu, Liang
   Zhao, Xue-Lian
   Wang, Li-Tao
   Zhao, Chun-Jian
   Huang, Han
   Zhu, Han-Lin
   Efferth, Thomas
   Gu, Cheng-Bo
   Fu, Yu-Jie
TI Seed oil of Rosa roxburghii Tratt against non-alcoholic fatty
   liver disease in vivo and in vitro through
   PPARα/PGC-1α-mediated mitochondrial oxidative metabolism
SO PHYTOMEDICINE
LA English
DT Article
DE Hepatology; Mitochondrial dysfunction; NALFD; Phytotherapy; Oxidative
   stress; PPAR alpha/PGC-1 alpha signaling; PBS, phosphate buffer saline;
   PGC-1 alpha, peroxisome proliferator-activated receptor gamma
   coactivator 1 alpha; p38 MAPK, p38 mitogen-activated protein kinase;
   PPAR alpha, peroxisome proliferator activated receptor alpha; TFAM,
   Mitochondrial transcription factor A; TGF-beta, transforming growth
   factor-beta; TNF-alpha, Tumor Necrosis Factor alpha; TNF-alpha, Tumor
   necrosis factor alpha; UCP1, uncoupling protein 1
ID SKELETAL-MUSCLE; ACID; ANTIOXIDANT; DYSFUNCTION; LIPOTOXICITY;
   DEFICIENCY; STEATOSIS; TISSUE
AB Background: Non-alcoholic fatty liver disease (NAFLD), characterized by hepatic steatosis and hepatocyte injury, is an obesity-induced metabolic dysregulation with few available therapeutic options. Enhancement of the mitochondrial function was considered as an effective treatment for NALFD. Unsaturated fatty acids (UFAs) have been shown to have beneficial effects on metabolic syndrome disease such as hyperlipidemia, coronary artery disease and cardiovascular diseases. The seed oil of Rosa roxburghii Tratt (ORRT) was of high quality in terms of its high amount of unsaturated fatty acids. However, the effects of ORRT on NALFD have not been reported so far.
   Purpose: The study aimed to evaluate the protective effects and molecular mechanism of ORRT for the treatment of NAFLD in vivo and in vitro.
   Methods: The beneficial effects, especially improving the mitochondrial function, and the potential mechanism of ORRT on NAFLD were studied both in vivo and in vitro. Lipid levels were determined by triglyceride (TG), total cholesterol (TC), and Oil Red O staining. Oxidative stress and inflammation were assessed by detecting anti-oxidant enzyme activity, MDA content, and ELISA assay. Blood TG, TC, HDL-c and LDL-c levels were measured in HFD mice. Western blot analyses were used to determine the levels of the protein involved in fatty acid oxidation, oxidative metabolism, and mitochondria biogenesis and function. The mitochondrial membrane potential level was measured by JC-1 staining to teste the effect of ORRT on mitochondrial function in vitro. GW6471 (inhibitor of PPAR alpha) was used to confirm the relationship between PPAR alpha and PGC-1 alpha.
   Results: ORRT significantly restrained NAFLD progression by attenuating lipid accumulation, oxidative stress and inflammatory response. Furthermore, ORRT upregulated thermogenesis-related gene expressions, such as uncoupling protein 1 (UCP1) and p38 mitogen-activated protein kinase (p38 MAPK). The results showed that the expression of key genes involved in fatty acid oxidation (e.g., CPT-1 alpha, ACADL, PPAR alpha) and in mitochondrial biogenesis and function (e.g., TFAM, NRF1, PGC-1 alpha, and COX IV) was significantly increased. Together with the observed MMP improvement, these findings suggested that ORRT activated the mitochondrial oxidative pathway. Additionally, GW6471 inhibited the ORRT on promoting the expression of PGC-1 alpha, CPT-1 alpha, and ACADL. In conclusion, ORRT possessed the potential to prevent lipid accumulation via the PPAR alpha/PGC-1 alpha signaling pathway, which could be developed as a natural health-promoting oil against NAFLD.
C1 [Ni, Hai-Yan; Yu, Liang; Zhao, Xue-Lian; Zhao, Chun-Jian; Huang, Han; Zhu, Han-Lin; Gu, Cheng-Bo] Northeast Forestry Univ, Coll Chem, Chem Engn & Resource Utilizat, Harbin 150040, Peoples R China.
   [Ni, Hai-Yan; Yu, Liang; Zhao, Xue-Lian; Zhao, Chun-Jian; Huang, Han; Zhu, Han-Lin; Gu, Cheng-Bo; Fu, Yu-Jie] Northeast Forestry Univ, Key Lab Forest Plant Ecol, Minist Educ, Harbin 150040, Peoples R China.
   [Ni, Hai-Yan; Yu, Liang; Zhao, Xue-Lian; Zhao, Chun-Jian; Huang, Han; Zhu, Han-Lin; Gu, Cheng-Bo; Fu, Yu-Jie] Northeast Forestry Univ, Engn Res Ctr Forest Biopreparat, Minist Educ, Harbin 150040, Peoples R China.
   [Wang, Li-Tao; Fu, Yu-Jie] Beijing Forestry Univ, Coll Forestry, Beijing 100083, Peoples R China.
   [Efferth, Thomas] Johannes Gutenberg Univ Mainz, Inst Pharmaceut & Biomed Sci, D-55128 Mainz, Germany.
C3 Northeast Forestry University - China; Northeast Forestry University -
   China; Ministry of Education - China; Ministry of Education - China;
   Northeast Forestry University - China; Beijing Forestry University;
   Johannes Gutenberg University of Mainz
RP Gu, CB (corresponding author), Northeast Forestry Univ, Coll Chem, Chem Engn & Resource Utilizat, Harbin 150040, Peoples R China.; Gu, CB; Fu, YJ (corresponding author), Northeast Forestry Univ, Key Lab Forest Plant Ecol, Minist Educ, Harbin 150040, Peoples R China.; Gu, CB; Fu, YJ (corresponding author), Northeast Forestry Univ, Engn Res Ctr Forest Biopreparat, Minist Educ, Harbin 150040, Peoples R China.; Fu, YJ (corresponding author), Beijing Forestry Univ, Coll Forestry, Beijing 100083, Peoples R China.
EM dilisatis@163.com; yujie_fu@163.com
RI GU, Chengbo/GWV-1823-2022; Zhao, Chunjian/AIF-0934-2022; Wang,
   Li-Tao/AGZ-1610-2022
OI Wang, Li-Tao/0000-0003-2623-2961; Efferth, Thomas/0000-0002-2637-1681
FU National Natural Science Foundation of China [31770619]; Funda-mental
   Research Funds for the Central Universities [2572020DR07]; research and
   development project of Applied Technology in Heilongjiang Province
   [GX18B003]; 111 Project [B20088]; Hei-longjiang Touyan Innovation Team
   Program (Tree Genetics and Breeding Innovation Team); Heilongjiang
   Provincial Natural Science Foundation of Joint Guidance Project
   [LH2021C015]
FX The authors gratefully acknowledge the financial supports by the
   National Natural Science Foundation of China (31770619) , Funda-mental
   Research Funds for the Central Universities (2572020DR07) , research and
   development project of Applied Technology in Heilongjiang Province
   (GX18B003) , the 111 Project (B20088) , Hei-longjiang Touyan Innovation
   Team Program (Tree Genetics and Breeding Innovation Team) , and the
   Heilongjiang Provincial Natural Science Foundation of Joint Guidance
   Project (LH2021C015) .
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NR 37
TC 28
Z9 34
U1 7
U2 76
PU ELSEVIER GMBH
PI MUNICH
PA HACKERBRUCKE 6, 80335 MUNICH, GERMANY
SN 0944-7113
EI 1618-095X
J9 PHYTOMEDICINE
JI Phytomedicine
PD APR
PY 2022
VL 98
AR 153919
DI 10.1016/j.phymed.2021.153919
EA JAN 2022
PG 14
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA 7X1YE
UT WOS:000913999300001
PM 35104757
DA 2025-06-11
ER

PT J
AU Cutillas-Tolín, A
   Adoamnei, E
   Navarrete-Muñoz, EM
   Vioque, J
   Moñino-García, M
   Jorgensen, N
   Chavarro, JE
   Mendiola, J
   Torres-Cantero, AM
AF Cutillas-Tolin, Ana
   Adoamnei, Evdochia
   Navarrete-Munoz, Eva M.
   Vioque, Jesus
   Monino-Garcia, Miriam
   Jorgensen, Niels
   Chavarro, Jorge E.
   Mendiola, Jaime
   Torres-Cantero, Alberto M.
TI Adherence to diet quality indices in relation to semen quality and
   reproductive hormones in young men
SO HUMAN REPRODUCTION
LA English
DT Article
DE AHEI-2010; DASH; dietary indices; reproductive hormones; rMED; semen
   quality
ID CARDIOMETABOLIC RISK-FACTORS; CORONARY-HEART-DISEASE; C-REACTIVE
   PROTEIN; FATTY-ACID INTAKE; MEDITERRANEAN DIET; DASH DIET; OXIDATIVE
   STRESS; PLASMA-CONCENTRATIONS; TESTICULAR FUNCTION; PESTICIDE-RESIDUES
AB STUDY QUESTION: Is adherence to an a priori defined diet quality indices [Alternate Healthy Index 2010 (AHEI-2010), relative Mediterranean diet score (rMED) or dietary approaches to stop hypertension (DASH)] associated with semen quality and reproductive hormone levels in young men?
   SUMMARY ANSWER: Greater adherence to the DASH diet is related to higher sperm counts.
   WHAT IS KNOWN ALREADY: Studies assessing the relationship between dietary intake and male reproductive function have mainly been focused on specific nutrients, food groups or data-driven dietary patterns, but the evidence on a priori defined dietary indices is still scarce.
   STUDY DESIGN, SIZE, DURATION: Cross-sectional study of 209 male university students recruited from October 2010 to November 2011 in Murcia Region (Southern Spain).
   PARTICIPANTS/MATERIALS, SETTING, METHODS: Healthy young men aged 18-23 years were included in this study. Diet was assessed using a validated food frequency questionnaire and three a priori-defined dietary indices (AHEI-2010, rMED and DASH) were calculated. Linear regression was used to analyze the relation between the three dietary indices and semen quality parameters and reproductive hormone levels accounting for potential confounders and covariates.
   MAIN RESULTS AND THE ROLE OF CHANCE: We found statistically significant positive associations between the DASH index and sperm concentration (P, trend = 0.04), total sperm count (P, trend = 0.04) and total motile sperm count (P, trend = 0.02). No associations were observed for other semen parameters or male reproductive hormones.
   LIMITATIONS, REASONS FOR CAUTION: Even though we adjusted for several known and suspected confounders we cannot exclude the possibility of residual or unmeasured confounding or chance findings. Subjects were blinded to the study outcomes thus reducing the potential influence on their report of diet. Our sample size may be too small to rule out associations with other semen parameters or reproductive hormones. Causal inference is limited, as usual with all observational studies.
   WIDER IMPLICATIONS OF THE FINDINGS: The results suggest that greater adherence to the DASH may help improve sperm counts. This study was carried out on young men from the general population. However, results may differ among other populations (e.g. infertile men). Therefore, further research is needed to confirm these findings and extend these results to other populations.
C1 [Cutillas-Tolin, Ana; Adoamnei, Evdochia; Monino-Garcia, Miriam; Mendiola, Jaime; Torres-Cantero, Alberto M.] Univ Murcia, Dept Publ Hlth Sci, Div Prevent Med Ne & Publ Hlth, Sch Med, E-30100 Murcia 30100, Spain.
   [Cutillas-Tolin, Ana; Adoamnei, Evdochia; Monino-Garcia, Miriam; Mendiola, Jaime; Torres-Cantero, Alberto M.] Biomed Res Inst Murcia IMIB Arrixaca, Hlth Res Methodol Grp, Murcia 30120, Spain.
   [Navarrete-Munoz, Eva M.; Vioque, Jesus] Univ Miguel Hernandez, Nutr Epidemiol Unit, Alicante 03550, Spain.
   [Navarrete-Munoz, Eva M.; Vioque, Jesus; Mendiola, Jaime; Torres-Cantero, Alberto M.] ISC III, CIBERESP, Madrid 28029, Spain.
   [Navarrete-Munoz, Eva M.; Vioque, Jesus] ISABIAL FISABIO Fdn, Inst Hlth & Biomed Res, Alicante, Spain.
   [Jorgensen, Niels] Univ Copenhagen, Rigshosp, Dept Growth & Reprod, DK-20100 Copenhagen, Denmark.
   [Chavarro, Jorge E.] Harvard TH Chan Sch Publ Hlth, Dept Nutr & Dept Epidemiol, Boston, MA 02115 USA.
   [Chavarro, Jorge E.] Brigham & Womens Hosp, Dept Med, Charming Div Network Med, Boston, MA 02115 USA.
   [Chavarro, Jorge E.] Harvard Med Sch, Boston, MA 02115 USA.
   [Torres-Cantero, Alberto M.] Virgen de la Arrixaca Univ Clin Hosp, Dept Prevent Med, Murcia 30120, Spain.
C3 University of Murcia; Hospital Clinico Universitario Virgen de la
   Arrixaca; Universidad Miguel Hernandez de Elche; CIBER - Centro de
   Investigacion Biomedica en Red; CIBERESP; General University Hospital of
   Alicante; Universidad Miguel Hernandez de Elche; Universitat d'Alacant;
   Instituto de Investigacion Sanitaria y Biomedica de Alicante (ISABIAL);
   University of Copenhagen; Rigshospitalet; Harvard University; Harvard
   T.H. Chan School of Public Health; Harvard University; Harvard
   University Medical Affiliates; Brigham & Women's Hospital; Harvard
   University; Harvard Medical School; Hospital Clinico Universitario
   Virgen de la Arrixaca
RP Adoamnei, E (corresponding author), Univ Murcia, Sch Med IMIB Arrixaca, Dept Publ Hlth Sci, Espinardo 3000, Murcia, Spain.
EM evdochia.adoamnei@um.es
RI Chavarro, Jorge/AAE-5665-2021; Navarrete-Muñoz, Eva/F-1666-2011;
   Cutillas-Tolín, Ana/AAH-1597-2021; Mendiola, Jaime/G-7829-2018;
   Torres-Cantero, Alberto/F-1087-2017; Adoamnei, Evdochia/G-7848-2018;
   Jørgensen, Niels/A-8148-2012; Vioque, Jesus/A-1066-2008
OI Torres-Cantero, Alberto M./0000-0001-5402-1016; Vioque,
   Jesus/0000-0002-2284-148X; Cutillas-Tolin, Ana/0000-0002-8728-9817;
   Mendiola, Jaime/0000-0002-0657-9346; Adoamnei,
   Evdochia/0000-0003-3633-2245; Monino-Garcia, Miriam/0000-0002-7949-1441
FU Fundacion Seneca [08808/PI/08, 19443/PI/14]; Ministerio de Ciencia e
   Innovacion, Instituto de Salud Carlos III (AES) [PI10/00985,
   PI13/01237]; National Institutes of Health [P30DK046200]
FX Fundacion Seneca (grants no. 08808/PI/08 and no. 19443/PI/14);
   Ministerio de Ciencia e Innovacion, Instituto de Salud Carlos III (AES)
   (grants no. PI10/00985 and no. PI13/01237); National Institutes of
   Health (grant P30DK046200),
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NR 79
TC 23
Z9 24
U1 1
U2 17
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0268-1161
EI 1460-2350
J9 HUM REPROD
JI Hum. Reprod.
PD OCT
PY 2019
VL 34
IS 10
BP 1866
EP 1875
DI 10.1093/humrep/dez157
PG 10
WC Obstetrics & Gynecology; Reproductive Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology; Reproductive Biology
GA JI5DB
UT WOS:000493485900004
PM 31560742
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Lyngbaek, MPP
   Legaard, GE
   Bennetsen, SL
   Feineis, CS
   Rasmussen, V
   Moegelberg, N
   Brinklov, CF
   Nielsen, AB
   Kofoed, KS
   Lauridsen, CA
   Ewertsen, C
   Poulsen, HE
   Christensen, R
   Van Hall, G
   Karstoft, K
   Solomon, TPJ
   Ellingsgaard, H
   Almdal, TP
   Pedersen, BK
   Ried-Larsen, M
AF Lyngbaek, Mark P. P.
   Legaard, Grit E.
   Bennetsen, Sebastian L.
   Feineis, Camilla S.
   Rasmussen, Villads
   Moegelberg, Nana
   Brinklov, Cecilie F.
   Nielsen, Anette B.
   Kofoed, Katja S.
   Lauridsen, Carsten A.
   Ewertsen, Caroline
   Poulsen, Henrik E.
   Christensen, Robin
   Van Hall, Gerrit
   Karstoft, Kristian
   Solomon, Thomas P. J.
   Ellingsgaard, Helga
   Almdal, Thomas P.
   Pedersen, Bente K.
   Ried-Larsen, Mathias
TI The effects of different doses of exercise on pancreatic β-cell function
   in patients with newly diagnosed type 2 diabetes: study protocol for and
   rationale behind the "DOSE-EX" multi-arm parallel-group randomised
   clinical trial
SO TRIALS
LA English
DT Article
DE Randomised controlled trial; Randomised clinical trial; Type 2 diabetes
   mellitus; Insulin resistance; beta-cell function; Lifestyle
   intervention; Exercise; Inflammation; Oxidative stress
ID SKELETAL-MUSCLE REGENERATION; GLYCATION END-PRODUCTS; GLYCEMIC CONTROL;
   INSULIN-RESISTANCE; PHYSICAL-ACTIVITY; OXIDATIVE STRESS; NUTRITION
   THERAPY; HEMOGLOBIN A(1C); GLUCOSE CONTROL; FATTY-ACIDS
AB BackgroundLifestyle intervention, i.e. diet and physical activity, forms the basis for care of type 2 diabetes (T2D). The current physical activity recommendation for T2D is aerobic training for 150min/week of moderate to vigorous intensity, supplemented with resistance training 2-3days/week, with no more than two consecutive days without physical activity. The rationale for the recommendations is based on studies showing a reduction in glycated haemoglobin (HbA1c). This reduction is supposed to be caused by increased insulin sensitivity in muscle and adipose tissue, whereas knowledge about effects on abnormalities in the liver and pancreas are scarce, with the majority of evidence stemming from in vitro and animal studies. The aim of this study is to investigate the role of the volume of exercise training as an adjunct to dietary therapy in order to improve the pancreatic beta -cell function in T2D patients less than 7years from diagnosis. The objective of this protocol for the DOSE-EX trial is to describe the scientific rationale in detail and to provide explicit information about study procedures and planned analyses.Methods/designIn a parallel-group, 4-arm assessor-blinded randomised clinical trial, 80 patients with T2D will be randomly allocated (1:1:1:1, stratified by sex) to 16weeks in either of the following groups: (1) no intervention (CON), (2) dietary intervention (DCON), (3) dietary intervention and supervised moderate volume exercise (MED), or (4) dietary intervention and supervised high volume exercise (HED). Enrolment was initiated December 15th, 2018, and will continue until N=80 or December 1st, 2021. Primary outcome is pancreatic beta-cell function assessed as change in late-phase disposition index (DI) from baseline to follow-up assessed by hyperglycaemic clamp. Secondary outcomes include measures of cardiometabolic risk factors and the effect on subsequent complications related to T2D. The study was approved by The Scientific Ethical Committee at the Capital Region of Denmark (H-18038298). Trial registration: The Effects of Different Doses of Exercise on Pancreatic beta -cell Function in Patients With Newly Diagnosed Type 2 Diabetes (DOSE-EX), NCT03769883, registered 10 December 2018 https://clinicaltrials.gov/ct2/show/NCT03769883). Any modification to the protocol, study design, and changes in written participant information will be approved by The Scientific Ethical Committee at the Capital Region of Denmark before effectuation.DiscussionThe data from this study will add knowledge to which volume of exercise training in combination with a dietary intervention is needed to improve beta -cell function in T2D. Secondarily, our results will elucidate mechanisms of physical activity mitigating the development of micro- and macrovascular complications correlated with T2D.
C1 [Lyngbaek, Mark P. P.; Legaard, Grit E.; Bennetsen, Sebastian L.; Feineis, Camilla S.; Rasmussen, Villads; Moegelberg, Nana; Brinklov, Cecilie F.; Nielsen, Anette B.; Kofoed, Katja S.; Karstoft, Kristian; Ellingsgaard, Helga; Pedersen, Bente K.; Ried-Larsen, Mathias] Copenhagen Univ Hosp, Rigshosp, Ctr Phys Act Res, Copenhagen, Denmark.
   [Lauridsen, Carsten A.; Ewertsen, Caroline] Copenhagen Univ Hosp, Rigshosp, Dept Radiol, Copenhagen, Denmark.
   [Lauridsen, Carsten A.] Copenhagen Univ Coll, Bachelors Degree Programme Radiog, Copenhagen, Denmark.
   [Poulsen, Henrik E.; Karstoft, Kristian] Univ Copenhagen, Bispebjerg Frederiksberg Hosp, Dept Clin Pharmacol, Copenhagen, Denmark.
   [Poulsen, Henrik E.; Pedersen, Bente K.] Univ Copenhagen, Dept Clin Med, Copenhagen, Denmark.
   [Christensen, Robin] Bispebjerg & Frederiksberg Hosp, Parker Inst, Musculoskeletal Stat Unit, Copenhagen, Denmark.
   [Christensen, Robin] Univ Southern Denmark, Odense Univ Hosp, Rheumatol Res Unit, Dept Clin Res, Odense, Denmark.
   [Van Hall, Gerrit] Univ Copenhagen, Fac Hlth & Med Sci, Biomed Sci, Copenhagen, Denmark.
   [Van Hall, Gerrit] Rigshosp, Clin Metabol Core Facil, Clin Biochem, Copenhagen, Denmark.
   [Solomon, Thomas P. J.] Blazon Sci, London, England.
   [Almdal, Thomas P.] Univ Copenhagen, Rigshosp, Dept Endocrinol PE, Copenhagen, Denmark.
   [Almdal, Thomas P.] Univ Copenhagen, Dept Immunol & Microbiol, Copenhagen, Denmark.
C3 University of Copenhagen; Copenhagen University Hospital;
   Rigshospitalet; University of Copenhagen; Copenhagen University
   Hospital; Rigshospitalet; University College Copenhagen; University of
   Copenhagen; Bispebjerg Hospital; University of Copenhagen; University of
   Copenhagen; Bispebjerg Hospital; University of Southern Denmark; Odense
   University Hospital; University of Copenhagen; Rigshospitalet;
   University of Copenhagen; Copenhagen University Hospital;
   Rigshospitalet; University of Copenhagen; Copenhagen University
   Hospital; University of Copenhagen
RP Ried-Larsen, M (corresponding author), Copenhagen Univ Hosp, Rigshosp, Ctr Phys Act Res, Copenhagen, Denmark.
EM mathias.ried-larsen@regionh.dk
RI Pedersen, Bente/AGR-3217-2022; Legård, Grit Elster/AGY-9607-2022;
   Karstoft, Kristian/MIT-1634-2025; Ried-Larsen, Mathias/GPX-7640-2022;
   Lyngbaek, Mark/AAM-3899-2020; Solomon, Thomas/I-4476-2019; Ellingsgaard,
   Helga/AAD-5705-2022
OI Feineis, Camilla Sofie/0000-0002-6040-1151; Ried-Larsen,
   Mathias/0000-0002-8388-5291; Christensen, Robin/0000-0002-6600-0631; van
   Hall, Gerrit/0000-0002-2519-8127; Legard, Grit
   Elster/0000-0002-5832-4556; Solomon, Thomas/0000-0002-0579-284X;
   Bennetsen, Sebastian/0000-0002-3554-8565
FU TrygFonden [124708]; Svend Andersen Fonden; Oak Foundation
   [OCAY-18-774-OFIL]; Danish Diabetes Academy
FX The Centre for Physical Activity Research (CFAS) is supported by
   TrygFonden (info@trygfonden.dk).The DOSE-EX study is supported by an
   additional grant from TrygFonden (ID: 124708) and Svend Andersen Fonden.
   Robin Christensen from the Parker Institute, Bispebjerg and
   Frederiksberg Hospital is supported by a core grant from the Oak
   Foundation (OCAY-18-774-OFIL). MPPL is funded by The Danish Diabetes
   Academy.
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NR 120
TC 9
Z9 9
U1 1
U2 8
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1745-6215
J9 TRIALS
JI Trials
PD APR 1
PY 2021
VL 22
IS 1
AR 244
DI 10.1186/s13063-021-05207-7
PG 26
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA RH8BR
UT WOS:000636437400005
PM 33794975
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Nasis, A
   Moir, S
   Meredith, IT
   Barton, TL
   Nerlekar, N
   Wong, DT
   Ko, BS
   Cameron, JD
   Mottram, PM
AF Nasis, Arthur
   Moir, Stuart
   Meredith, Ian T.
   Barton, Timothy L.
   Nerlekar, Nitesh
   Wong, Dennis T.
   Ko, Brian S.
   Cameron, James D.
   Mottram, Philip M.
TI Abnormal Left Ventricular Contractile Response to Exercise in the
   Absence of Obstructive Coronary Artery Disease Is Associated with
   Resting Left Ventricular Long-Axis Dysfunction
SO JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY
LA English
DT Article
DE Exercise echocardiography; Coronary angiography; Myocardial function;
   Microvascular dysfunction
ID MITRAL ANNULUS VELOCITY; CARDIAC SYNDROME-X; TIMI FRAME COUNT;
   DOPPLER-ECHOCARDIOGRAPHY; DOBUTAMINE STRESS; AMERICAN-SOCIETY;
   RECOMMENDATIONS; RESERVE; RELAXATION; DIAGNOSIS
AB Background: The etiology of reduced left ventricular (LV) ejection fraction after exercise, without obstructive coronary artery disease or other established causes, is unclear. The aims of this study were to determine whether patients undergoing treadmill stress echocardiography with this abnormal LV contractile response to exercise (LVCRE) without established causes have resting LV long-axis dysfunction or microvascular dysfunction and to determine associations with this abnormal LVCRE.
   Methods: Of 5,275 consecutive patients undergoing treadmill stress echocardiography, 1,134 underwent cardiac computed tomography angiography or invasive angiography. Having excluded patients with obstructive coronary artery disease, hypertensive response, submaximal heart rate response, resting LV ejection fraction <50%, and valvular disease, 110 with "abnormal LVCRE" and 212 with "normal LVCRE" were analyzed. Resting mitral amular velocities were measured to assess LV long-axis function. Myocardial blush grade and corrected Thrombolysis In Myocardial Infarction frame count were determined angiographically to assess microvascular function.
   Results: Comparing normal LVCRE with abnormal LVCRE, age (mean, 59.7 +/- 11.1 vs 61.4 +/- 10.0 years), hypertension (53% vs 55%), diabetes (16% vs 20%), and body mass index (mean, 29.1 +/- 5.4 vs 29.5 +/- 6.4 kg/m(2)) were similar (P > .05). Abnormal LVCRE had reduced resting LV long-axis function with lower septal (mean, 6.1 +/- 1.9 vs 7.7 +/- 2.2 cm/sec) and lateral (mean, 8.1 +/- 2.9 vs 10.4 +/- 3.0 cm/sec) e' velocities (P < .001) and larger resting left atrial volumes (mean, 37.3 +/- 10.1 vs 31.1 +/- 7.2 mL/m(2), P < .001). On multivariate analysis, female gender (odds ratio [OR], 1.21; 95% confidence interval [CI], 1.15-1.99; P <.001), exaggerated chronotropic response (OR, 1.49; 95% CI, 1.09-2.05; P < .001), resting left atrial volume (OR, 2.38; 95% CI, 1.63-3.47; P < .001), and resting lateral e' velocity (OR, 1.70; 95% CI, 1.22-2.49; P = .003) were associated with abnormal LVCRE, but not myocardial blush grade or corrected Thrombolysis In Myocardial Infarction frame count.
   Conclusions: An abnormal LVCRE in the absence of established causes is associated with resting LV long-axis dysfunction and is usually seen in women.
C1 Monash Hlth, MonashHEART, Monash Cardiovasc Res Ctr, Melbourne, Australia.
   Monash Univ, Dept Med MMC, Melbourne, Vic 3004, Australia.
C3 Monash Health; Monash University
RP Nasis, A (corresponding author), MonashHEART, Monash Cardiovasc Res Ctr, 246 Clayton Rd, Clayton, Vic 3168, Australia.
EM arthur.nasis@monashhealth.org
RI Cameron, james/GQP-4595-2022
OI Nerlekar, Nitesh/0000-0002-3437-8648; Cameron, James/0000-0003-0589-0367
FU National Health and Medical Research Council of Australia; National
   Heart Foundation of Australia; Monash Health Senior Medical Staff
   Association
FX Dr Nasis holds research scholarships from the National Health and
   Medical Research Council of Australia, the National Heart Foundation of
   Australia, and the Monash Health Senior Medical Staff Association.
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NR 39
TC 9
Z9 10
U1 0
U2 3
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0894-7317
J9 J AM SOC ECHOCARDIOG
JI J. Am. Soc. Echocardiogr.
PD JAN
PY 2015
VL 28
IS 1
BP 95
EP 105
DI 10.1016/j.echo.2014.09.015
PG 11
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA AX9WJ
UT WOS:000347249700007
PM 25450014
DA 2025-06-11
ER

PT J
AU Sanyal, AJ
   Campbell-Sargent, C
   Mirshahi, F
   Rizzo, WB
   Contos, MJ
   Sterling, RK
   Luketic, VA
   Shiffman, ML
   Clore, JN
AF Sanyal, AJ
   Campbell-Sargent, C
   Mirshahi, F
   Rizzo, WB
   Contos, MJ
   Sterling, RK
   Luketic, VA
   Shiffman, ML
   Clore, JN
TI Nonalcoholic steatohepatitis: Association of insulin resistance and
   mitochondrial abnormalities
SO GASTROENTEROLOGY
LA English
DT Article; Proceedings Paper
CT Meeting of the American-Association-for-the-Study-of-Liver-Diseases
CY MAY, 1999
CL ORLANDO, FL
SP Amer Assoc Study Liver Dis
ID FATTY LIVER; GLUCOSE-METABOLISM; NATURAL-HISTORY; SYNDROME-X;
   HYPERTENSION; OBESITY; HYPERINSULINEMIA
AB Background & Aims: The pathogenesis of nonalcoholic steatohepatitis (NASH) is unknown. We tested the hypothesis that NASH is associated with 2 defects: (1) peripheral insulin resistance, which increases lipolysis, delivery of free fatty acids (FFA) to the liver, and hepatic fatty acid beta oxidation, thereby creating oxidative stress; and (2) an abnormality within the hepatocytes that might render them more susceptible to injury from oxidative stress. Methods: The hypothesis was tested by evaluation of (1) insulin resistance by a 2-step hyperinsulinemic (10 and 40 mU . m(-2) min(-1)) euglycemic clamp; (2) insulin effects on lipolysis by enrichment of [U-C-13]glycerol; (3) frequency and severity of structural defects in hepatocyte mitochondria in vivo; (4) fatty acid beta oxidation from serum IF-OH butyrate], release of water-soluble radioactivity from H-3-palmitate by cultured fibroblasts and urinary dicarboxylic acid excretion; and (5) hepatic lipid peroxidation by immunohistochemical staining for 9-nitrotyrosine (3-NT). Subjects with NASH (n = 6-10 for different studies) were compared with those with fatty liver (n = 6) or normal controls (n = 6), Results: HASH and fatty liver were both associated with insulin resistance, with mean glucose infusion rates (normal/fatty liver/NASH) of step 1, 4.5/1,6/0.9; step 2, 9.5/7.7/4.5 (P < 0.03 for both steps). Although baseline rates of glycerol appearance were higher in those with NASH than in those with fatty liver (means, 14.6 vs. 21.6 mu mol . kg(-l) . min(-1); P < 0.05), neither group significantly suppressed glycerol appearance at insulin infusion rates of 10 mU m-2 min-l. NASH was associated with loss of mitochondrial cristae and paracrystalline inclusions in 9 of 10 subjects, compared with 0 of 6 subjects with fatty liver. However, no evidence of a generalized defect in fatty acid P oxidation was noted in any group. Also, mean [beta-OH butyrate] was highest in those with NASH (means, 90 vs. 110 vs. 160 mu mol/L; P < 0,04). Increased staining for 3-NT was present in fatty liver, and even greater staining was seen in NASH. Conclusions: These data indicate that peripheral insulin resistance, increased fatty acid P oxidation, and hepatic oxidative stress are present in both fatty liver and NASH, but HASH alone is associated with mitochondrial structural defects.
C1 Virginia Commonwealth Univ, Med Coll Virginia, Div Gastroenterol Hepatol, Dept Internal Med, MCV Box 980711, Richmond, VA 23298 USA.
   Virginia Commonwealth Univ, Med Coll Virginia, Dept Pediat, Richmond, VA 23298 USA.
   Virginia Commonwealth Univ, Med Coll Virginia, Dept Pathol, Richmond, VA 23298 USA.
   Virginia Commonwealth Univ, Med Coll Virginia, Div Endocrinol, Dept Internal Med, Richmond, VA 23298 USA.
C3 Virginia Commonwealth University; Virginia Commonwealth University;
   Virginia Commonwealth University; Virginia Commonwealth University
RP Virginia Commonwealth Univ, Med Coll Virginia, Div Gastroenterol Hepatol, Dept Internal Med, MCV Box 980711, Richmond, VA 23298 USA.
EM ajsanyal@hsc.vcu.edu
RI Sterling, Richard/AAV-1598-2020
FU NCRR NIH HHS [MO1 RR 00065-38] Funding Source: Medline; NIDDK NIH HHS
   [DK 43013, DK 02755] Funding Source: Medline
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NR 47
TC 1664
Z9 1871
U1 5
U2 131
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0016-5085
EI 1528-0012
J9 GASTROENTEROLOGY
JI Gastroenterology
PD APR
PY 2001
VL 120
IS 5
BP 1183
EP 1192
DI 10.1053/gast.2001.23256
PG 10
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Gastroenterology & Hepatology
GA 415GW
UT WOS:000167713700016
PM 11266382
OA Bronze
DA 2025-06-11
ER

PT J
AU Peralta, I
   Marrassini, C
   Saint Martin, M
   Plantamura, YS
   Cogoi, L
   Pellegrino, N
   Alonso, MR
   Anesini, C
AF Peralta, Ignacio
   Marrassini, Carla
   Saint Martin, Malen
   Plantamura, Yanina Santander
   Cogoi, Laura
   Pellegrino, Nestor
   Alonso, Maria Rosario
   Anesini, Claudia
TI Anti-hyperglycaemic effect and nutritional properties of an aqueous
   extract of Larrea divaricata Cav. (jarilla) in
   streptozotocin-induced diabetes in mice
SO JOURNAL OF ETHNOPHARMACOLOGY
LA English
DT Article
DE Larrea divaricata; antioxidant activity; Antidiabetic activity;
   Nutritional properties
ID NORDIHYDROGUAIARETIC ACID; DIETARY FIBER; ANTIOXIDANT; MASOPROCOL;
   PLANTS
AB Ethnopharmacological relevance: Larrea divaricata Cav. (Zygophyllaceae) (jarilla) is a native plant of South America widely distributed across Argentina and used in popular medicine to treat diabetes and hypercholesterolemia by the Diaguita-Calchaqui, Amaichas, and Quilmes indigenous communities and by non-indigenous population (criollos) of Calamuchita, in the province of C acute accent ordoba, Argentina. L. divaricata has also proved to have anti-inflammatory properties. However, the antidiabetic effects and the nutritional properties of the aqueous extract (AE) of this plant remain to be scientifically determined.Aim of the study: The aim of the present work was to evaluate the capacity of an aqueous extract of L. divaricata (AE) and its main compound nordihydroguaiaretic acid (NDGA) to modulate the glucose, cholesterol, triglycerides and oxidative stress levels in STZ-induced diabetes in mice. The general objective of the present work was to search for extracts that can be used as adjuvant therapy in for diabetes. The suitability of the extract to be used as a dietary supplement was also assessed by determining the proximate amount of fibre, lipids, proteins, and minerals.Materials and methods: Diabetes was induced in mice by administration of streptozotocin (STZ). AE and NDGA were administered by the oral route. The animals' glycaemia was periodically monitored in blood samples obtained from the tail vein. The glucose dehydrogenase method was used. The effect of the AE on cholesterol, triglycerides, oxidative stress, lipid peroxidation and reduced glutathione (GSH) levels were determined in plasma samples by spectrophotometric assays.Results: In STZ-treated mice, AE significantly decreased glucose (33%, ****p < 0.0001) and cholesterol levels (32%, **p < 0.01). AE and NDGA decreased lipid peroxidation (30% and 38%, respectively, ****p < 0.0001), and increased GSH levels (20%, **p < 0.01). The effects of AE on glucose and lipid levels could not be ascribed to NDGA; however, this compound was involved in the extract antioxidant effects. The overall effects of AE were probably related to its antioxidant activity and to the anti-hyperglycaemic effect mainly mediated by flavonoids, fibre (carbohydrates) and mineral elements such as potassium, calcium, magnesium, and zinc. The AE protein content also confers the extract nutritional properties.Conclusions: These results support the hypothesis that AE could be used as a therapeutic adjuvant or as a nutritional supplement to control glucose levels and lipid metabolism in metabolic syndrome-associated diseases. Moreover, these results scientifically reinforce the popular use of the plant.
C1 [Peralta, Ignacio; Marrassini, Carla; Saint Martin, Malen; Cogoi, Laura; Alonso, Maria Rosario; Anesini, Claudia] Univ Buenos Aires, Consejo Nacl Invest Cient & Tecn CONICET, Inst Quim & Metab Farmaco IQUIMEFA, Buenos Aires, Argentina.
   [Peralta, Ignacio; Marrassini, Carla; Saint Martin, Malen; Cogoi, Laura; Anesini, Claudia] Univ Buenos Aires, Fac Farm & Bioquim, Catedra Farmacognosia, Buenos Aires, Argentina.
   [Plantamura, Yanina Santander] Univ Buenos Aires, Fac Farm & Bioquim, Catedra Farmacol, Buenos Aires, Argentina.
   [Pellegrino, Nestor] Univ Buenos Aires, Fac Farm & Bioquim, Catedra Bromatol, Buenos Aires, Argentina.
   [Marrassini, Carla] Biochem Univ Buenos Aires, CONICET Fac Pharm, IQUIMEFA UBA, Junin 956,2nd floor, Buenos Aires, Argentina.
C3 Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET);
   University of Buenos Aires; University of Buenos Aires; University of
   Buenos Aires; University of Buenos Aires
RP Marrassini, C (corresponding author), Biochem Univ Buenos Aires, CONICET Fac Pharm, IQUIMEFA UBA, Junin 956,2nd floor, Buenos Aires, Argentina.
EM cmarra@ffyb.uba.ar
RI Maldonado, María/AAP-1492-2021
OI Santander Plantamura, Yanina Alejandra/0009-0003-6501-7268
FU CONICET [PIP 00067 CO]; Buenos Aires University [PIP 00067 CO]; 
   [20020130100686BA]
FX This work was supported by grant PIP 00067 CO from CONICET and grant
   UBACYT 20020130100686BA from Buenos Aires University.
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NR 38
TC 3
Z9 3
U1 0
U2 4
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0378-8741
EI 1872-7573
J9 J ETHNOPHARMACOL
JI J. Ethnopharmacol.
PD OCT 5
PY 2022
VL 296
AR 115429
DI 10.1016/j.jep.2022.115429
EA JUN 2022
PG 9
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA 2N6MB
UT WOS:000818489300006
PM 35659916
DA 2025-06-11
ER

PT J
AU McCarty, MF
   DiNicolantonio, JJ
AF McCarty, Mark F.
   DiNicolantonio, James J.
TI The protection conferred by chelation therapy in post-MI diabetics might
   be replicated by high-dose zinc supplementation
SO MEDICAL HYPOTHESES
LA English
DT Article
ID PODOCYTE-SPECIFIC OVEREXPRESSION; CORONARY-HEART-DISEASE; PANCREATIC
   BETA-CELLS; OXIDATIVE STRESS; VITAMIN-C; ENHANCED DELIVERY; CADMIUM
   EXPOSURE; GENE-EXPRESSION; WILSONS-DISEASE; COPPER-BINDING
AB The recent Trial to Assess Chelation Therapy (TACT) study, enrolling subjects who had previously experienced a myocardial infarction, has provided strong evidence that intravenous chelation therapy can markedly reduce risk for mortality and vascular events in diabetics, whereas no discernible benefit was observed in non-diabetics. It has plausibly been suggested that this reflects a role for transition metal ions - iron or copper - in the genesis of advanced glycation end products, key mediators of diabetic complications that can destabilize plaque. Since phlebotomy therapy fails to prevent vascular events in diabetics, we hypothesize that labile copper may be the chief culprit whose removal by chelation mediated the benefit observed in TACT. If so, strategies less time and labor intensive than chelation therapy might provide comparable benefit. A number of recent studies report that the copper-specific orally-active chelator trientine can reduce risk for range of diabetic complications in rodents; a clinical trial with this agent demonstrated some decrease in left ventricular mass in diabetics with ventricular hypertrophy. However, until this agent becomes less expensive, supplementation with high-dose zinc may represent a more feasible alternative. Zinc opposes the absorption and redox activity of copper via induction of the antioxidant protein metallothionein, which binds copper tightly. A great many studies demonstrate that increased expression of metallothionein decreases risk for tissue damage in diabetic rodents, and in some of these studies metallothionein expression was boosted by supplemental zinc. Zinc supplementation also modestly improves glycemic control in type 2 diabetics, and might reduce risk for diabetes by protecting pancreatic beta cells from oxidative stress. A long term study assessing the impact of supplementing diabetics with high-dose zinc, assessing risk for mortality, vascular events, and diabetic complications, may be warranted. Histidine, which readily forms complexes with copper that possess superoxide dismutase activity, also has potential for alleviating the contribution of loosely bound copper to AGE formation; moreover, in a recent clinical study, supplemental histidine improved insulin sensitivity and exerted anti-inflammatory and antioxidant effects in women with metabolic syndrome. Since ascorbate can reduce labile copper and thereby enhance its pathogenicity, the impact of high-dose ascorbate supplementation on cardiovascular risk in diabetics should receive further study. (C) 2015 Elsevier Ltd. All rights reserved.
C1 [McCarty, Mark F.] Catalyt Longev, Carlsbad, CA 92009 USA.
   [DiNicolantonio, James J.] St Lukes Hosp, Mid Amer Heart Inst, Kansas City, MO 64111 USA.
C3 Saint Luke's Mid America Heart Institute; Saint Luke's Hospital -
   Missouri
RP McCarty, MF (corresponding author), Catalyt Longev, 7831 Rush Rose Dr,Apt 316, Carlsbad, CA 92009 USA.
EM markfmccarty@gmail.com; jjnicol@gmail.com
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NR 95
TC 4
Z9 4
U1 0
U2 18
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0306-9877
EI 1532-2777
J9 MED HYPOTHESES
JI Med. Hypotheses
PD MAY
PY 2015
VL 84
IS 5
BP 451
EP 455
DI 10.1016/j.mehy.2015.01.038
PG 5
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA CF6NH
UT WOS:000352672900010
PM 25682188
DA 2025-06-11
ER

PT J
AU Yang, HJ
   Zhang, T
   Wu, XG
   Kim, MJ
   Kim, YH
   Yang, ES
   Yoon, YS
   Park, S
AF Yang, Hye-Jeong
   Zhang, Ting
   Wu, Xuan-Gao
   Kim, Min-Jung
   Kim, Young-Ho
   Yang, Eun-Suk
   Yoon, Yeong-Seok
   Park, Sunmin
TI Aqueous Blackcurrant Extract Improves Insulin Sensitivity and Secretion
   and Modulates the Gut Microbiome in Non-Obese Type 2 Diabetic Rats
SO ANTIOXIDANTS
LA English
DT Article
DE blackcurrants; insulin sensitivity; insulin secretion; inflammation;
   &#946; -cell mass; gut microbiota
ID GLUCAGON-LIKE PEPTIDE-1; BETA-CELL PROLIFERATION; HIGH-FAT DIET;
   METABOLIC SYNDROME; BLOOD-GLUCOSE; RIBES-NIGRUM; ANTHOCYANINS; MELLITUS;
   MASS; PANCREATECTOMY
AB This study was undertaken to determine whether aqueous blackcurrant extracts (BC) improve glucose metabolism and gut microbiomes in non-obese type 2 diabetic animals fed a high-fat diet and to identify the mechanism involved. Partially pancreatectomized male Sprague-Dawley rats were provided a high-fat diet containing 0% (control), 0.2% (L-BC; low dosage), 0.6% (M-BC; medium dosage), and 1.8% (H-BC; high dosage) blackcurrant extracts; 0.2% metformin (positive-C); plus 1.8%, 1.6%, 1.2%, 0%, and 1.6% dextrin, specifically indigestible dextrin, daily for 8 weeks. Daily blackcurrant extract intakes were equivalent to 100, 300, and 900 mg/kg body weight (bw). After a 2 g glucose or maltose/kg bw challenge, serum glucose and insulin concentrations during peak and final states were obviously lower in the M-BC and H-BC groups than in the control group (p < 0.05). Intraperitoneal insulin tolerance testing showed that M-BC and H-BC improved insulin resistance. Hepatic triglyceride deposition, TNF-alpha expression, and malondialdehyde contents were lower in the M-BC and H-BC groups than in the control group. Improvements in insulin resistance in the M-BC and H-BC groups were associated with reduced inflammation and oxidative stress (p < 0.05). Hyperglycemic clamp testing showed that insulin secretion capacity increased in the acute phase (2 to 10 min) in the M-BC and H-BC groups and that insulin sensitivity in the hyperglycemic state was greater in these groups than in the control group (p < 0.05). Pancreatic beta-cell mass was greater in the M-BC, H-BC, and positive-C groups than in the control group. Furthermore, beta-cell proliferation appeared to be elevated and apoptosis was suppressed in these three groups (p < 0.05). Serum propionate and butyrate concentrations were higher in the M-BC and H-BC groups than in the control group. BC dose-dependently increased alpha-diversity of the gut microbiota and predicted the enhancement of oxidative phosphorylation-related microbiome genes and downregulation of carbohydrate digestion and absorption-related genes, as determined by PICRUSt2 analysis. In conclusion, BC enhanced insulin sensitivity and glucose-stimulated insulin secretion, which improved glucose homeostasis, and these improvements were associated with an incremental increase of the alpha-diversity of gut microbiota and suppressed inflammation and oxidative stress.
C1 [Yang, Hye-Jeong; Kim, Min-Jung] Korean Food Res Inst, Res Div Food Funct, Wanjoo 55365, South Korea.
   [Zhang, Ting; Wu, Xuan-Gao; Park, Sunmin] Hoseo Univ, Dept Bioconvergence Syst, Asan 31499, South Korea.
   [Kim, Young-Ho; Yoon, Yeong-Seok] Hanter Co Ltd, Jeongeup 56204, South Korea.
   [Yang, Eun-Suk] Jiwon Co Ltd, Jeongeup 56212, South Korea.
   [Park, Sunmin] Hoseo Univ, Dept Food & Nutr, Obes Diabet Res Ctr, Asan 31499, South Korea.
C3 Korea Food Research Institute (KFRI); Hoseo University; Hoseo University
RP Park, S (corresponding author), Hoseo Univ, Dept Bioconvergence Syst, Asan 31499, South Korea.; Park, S (corresponding author), Hoseo Univ, Dept Food & Nutr, Obes Diabet Res Ctr, Asan 31499, South Korea.
EM yhj@kfri.re.kr; zhangting92925@gmail.com; niyani0@naver.com;
   kmj@kfri.re.kr; kimyh@tiumter.com; yanges@tiumter.com;
   yoonys@tiumter.com; smpark@hoseo.edu
RI zhang, ting/GXV-1734-2022; chen, jiahong/GYR-2917-2022; WU,
   XUAN/ISS-8430-2023
OI Park, Sunmin/0000-0002-6092-8340; Yoon, Yeong-Seok/0000-0002-7103-6460;
   ZHANG, TING/0000-0002-5949-3941
FU "Food Functionality Evaluation program" under the Ministry of
   Agriculture, Food and Rural Affairs; Korea Food Research Institute
FX This work was supported by "Food Functionality Evaluation program" under
   the Ministry of Agriculture, Food and Rural Affairs and partly Korea
   Food Research Institute.
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NR 55
TC 27
Z9 27
U1 0
U2 11
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD MAY
PY 2021
VL 10
IS 5
AR 756
DI 10.3390/antiox10050756
PG 21
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA SG3TG
UT WOS:000653363600001
PM 34068659
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Turkmen, M
   Barutcu, I
   Esen, AM
   Karakaya, O
   Esen, O
   Basaran, Y
AF Turkmen, M
   Barutcu, I
   Esen, AM
   Karakaya, O
   Esen, O
   Basaran, Y
TI Comparison of exercise QRS amplitude changes in patients with slow
   coronary flow versus significant coronary stenosis
SO JAPANESE HEART JOURNAL
LA English
DT Article
DE slow coronary flow; Athens QRS score; ischemia
ID ARTERY DISEASE INDEX; ANGINA-PECTORIS; Q-WAVE; MYOCARDIAL-ISCHEMIA;
   VASODILATOR RESERVE; SYNDROME-X; S-WAVE; R-WAVE; DIAGNOSIS; ARTERIOGRAMS
AB Exercise Q, R, and S wave amplitude changes, called the QRS score, have been reported to be a marker of exercise-induced myocardial ischemia. Therefore, in this study, using the exercise QRS score, we sought to determine if slow coronary flow (SCF) phenomenon is associated with the exercise-induced myocardial ischemia.
   This retrospective study included 23 patients evaluated for suspected coronary artery disease and found to have SCF (group I) and 19 Subjects with angiographically-defined significant coronary artery stenosis (group II). All study subjects underwent treadmill exercise testing using the modified Bruce protocol. For each subject the amplitude of the Q, R, and S waves in leads aVF and V-5 was measured manually using calipers before and immediately after exercise. The QRS score was calculated by subtracting the Q, R, and S wave differences in leads aVF and V-5.
   There was no difference between the two groups with respect to demographic properties. The peak heart rate achieved, baseline and peak systolic-diastolic blood pressure, exercise duration, and the metabolic equivalent values were similar in both groups. The maximum ST-seginent depression ratio was significantly lower in patients with SCF than those of significant coronary stenosis (0.8 +/- 0.4 vs 1.3 +/- 0.5 P = 0.001, respectively). However, the exercise QRS score was found to be similar in both groups (3.3 +/- 2.3 vs 2.1 +/- 3.0 P = 0.2, respectively).
   The data suggest that SCF phenornenon may alone lead to myocardial ischemia even in the absence of obstructed major epicardial coronary arteries as detected by similar exercise QRS scores to those of significant coronary artery stenosis.
C1 Kosuyolu Heart Educ & Res Hosp, Dept Cardiol, Istanbul, Turkey.
   Istanbul Univ, Cardiol Inst, Dept Cardiol, Istanbul, Turkey.
C3 Istanbul Kartal Kosuyolu Yuksek Ihtisas Training & Research Hospital;
   Istanbul University
RP 19 Mayis Mahallesi Sarikanarya Sok,Muhsinbey Apt, Istanbul, Turkey.
RI Karakaya, Osman/KPB-5126-2024; Esen, Onur/ACE-5915-2022; TURKMEN,
   MEHMET/IWD-9632-2023
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NR 36
TC 8
Z9 10
U1 0
U2 2
PU INT HEART JOURNAL ASSOC
PI TOKYO
PA UNIV TOKYO, GRADUATE SCHOOL MEDICINE, DEPT CARDIOVASCULAR MEDICINE,
   HONGO 7-3-1, BUNKYO-KU, TOKYO, 113-8655, JAPAN
SN 0021-4868
J9 JPN HEART J
JI Jpn. Heart J.
PD MAY
PY 2004
VL 45
IS 3
BP 419
EP 428
DI 10.1536/jhj.45.419
PG 10
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 849GV
UT WOS:000223527600006
PM 15240962
OA Bronze
DA 2025-06-11
ER

PT J
AU Nieto-Lima, B
   Cano-Martínez, A
   Zarco-Olvera, G
   Massó-Rojas, FA
   Páez-Arenas, A
   Guarner-Lans, V
AF Nieto-Lima, B.
   Cano-Martinez, A.
   Zarco-Olvera, G.
   Masso-Rojas, F. A.
   Paez-Arenas, A.
   Guarner-Lans, V.
TI GCSF Partially Repairs Heart Damage Induced by Repetitive β-adrenergic
   Stimulation in Mice: Potential Role of the Mobilized Bone Marrow-derived
   Cells
SO INTERNATIONAL JOURNAL OF PHARMACOLOGY
LA English
DT Article
DE Heart damage; beta-adrenergic stimulation; mobilized bone marrow-derived
   cells; granulocyte colony stimulating factor; fibrosis
ID INDUCED MYOCARDIAL-INFARCTION; SMOOTH MUSCLE ACTIN; G-CSF; OXIDATIVE
   STRESS; CARDIAC-HYPERTROPHY; HEMATOPOIETIC STEM; ISOPROTERENOL; FAILURE;
   RATS; NECROSIS
AB Background: Granulocyte Colony Stimulating Factor (GCSF) repairs acute heart damage. The main mechanism is its direct action on cardiac tissue. However, the role of the mobilized bone marrow-derived cells by GCSF is less explored. Pathologies such as obesity, mental stress and hypertension trigger chronic heart diseases through stimulation of the beta-adrenergic system. Therefore, the effect of GCSF and of isolated mobilized blood marrow cells in a mouse model of heart damage induced by repeated beta-adrenergic stimulation with isoproterenol was evaluated. Materials and Methods: Two experimental approaches were used: (1) Endogenous mobilization with GCSF was achieved directly in mice with heart damage (5 mg kg(-1) day(-1), 7 days,s.c.). (2) Mobilized bone marrow-derived cells were isolated, labeled and inoculated to other mice with heart damage 1 and 30 days after damage. Ventricular hypertrophy, fibrosis, heart rate and mean blood pressure were measured. Inoculated cells were tracked in the heart. Results: GCSF reduced fibrosis; while, inoculated cells diminished fibrosis and mean blood pressure. Inoculation 30 days post-damage reduced fibrosis even more. Ventricular hypertrophy and heart rate were not restored with any treatment. Inoculated bone marrow-derived cells which were enriched in hematopoietic stem and progenitor cells migrated to the area of damage and some were alpha SMA-positive. Conclusion: GCSF partially restores heart damage produced by the repetitive beta-adrenergic stimulation. Some mobilized bone marrow-derived cells migrate to the area of damage and are alpha SMA-positive, a phenotype related to cardiac sarcomerogenesis, cardiac muscle differentiation and cardiomyocyte rhythm, which could contribute to their beneficial effect. However, other mechanisms that could also be synergistically acting remain to be studied. A pool containing a diversity of cell types mobilized by GCSF, diminishes fibrosis and blood pressure in hearts damaged by repetitive stimulation of the beta-adrenergic system, independently from the presence of the factor. Stimulation of this system is found in conditions such as obesity, metabolic syndrome or hypertension. Therefore, through this mechanism of GCSF, there exists the possibility of restoration of heart damage by mobilizing a pool of easily accessible cells with the factor, without having to isolate particular cell types nor having to expose the patients to invasive procedures.
C1 [Nieto-Lima, B.; Cano-Martinez, A.; Guarner-Lans, V.] Inst Nacl Caardiol Ignacio Chavez, Dept Physiol, Juan Badiano 1, Mexico City 14080, DF, Mexico.
   [Zarco-Olvera, G.] Inst Nacl Caardiol Ignacio Chavez, Dept Pharmacol, Mexico City, DF, Mexico.
   [Masso-Rojas, F. A.; Paez-Arenas, A.] Inst Nacl Caardiol Ignacio Chavez, Dept Physiol, Cell Biol Sect, Mexico City, DF, Mexico.
   [Nieto-Lima, B.] Univ Nacl Autonoma Mexico, Dept Biol Sci, Mexico City, DF, Mexico.
C3 Universidad Nacional Autonoma de Mexico
RP Guarner-Lans, V (corresponding author), Inst Nacl Caardiol Ignacio Chavez, Dept Physiol, Juan Badiano 1, Mexico City 14080, DF, Mexico.
RI Guarner-Lans, Verónica/AFW-3723-2022; NIETO, BETZABE/B-3738-2018
OI NIETO, BETZABE/0000-0002-6230-6393; Guarner-Lans,
   Veronica/0000-0002-2655-7590
FU CONACyT [169736, 255108]; INCICH [12-758]
FX The authors thank CONACyT for grant 169736 to CMA and scholarship 255108
   to NLB and INCICH for grant 12-758 to CMA.
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TC 4
Z9 4
U1 0
U2 2
PU ASIAN NETWORK SCIENTIFIC INFORMATION-ANSINET
PI FAISALABAD
PA 308-LASANI TOWN, SARGODHA RD, FAISALABAD, 38090, PAKISTAN
SN 1811-7775
EI 1812-5700
J9 INT J PHARMACOL
JI Int. J. Pharmacol.
PY 2016
VL 12
IS 7
BP 689
EP 700
DI 10.3923/ijp.2016.689.700
PG 12
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA ED6HX
UT WOS:000388957800002
DA 2025-06-11
ER

PT J
AU Crawford, N
   Martell, M
   Nielsen, T
   Khalil, B
   Imtiaz, F
   Nguidjo, E
   Newell-Caito, JL
   Bornhorst, J
   Schwerdtle, T
   Caito, SW
AF Crawford, Nicole
   Martell, Megan
   Nielsen, Tyson
   Khalil, Belal
   Imtiaz, Farooq
   Nguidjo, Etienne
   Newell-Caito, Jennifer L.
   Bornhorst, Julia
   Schwerdtle, Tanja
   Caito, Samuel W.
TI Methylmercury-Induced Metabolic Alterations in Caenorhabditis
   elegans Are Diet-Dependent
SO TOXICS
LA English
DT Article
DE methylmercury; diet; cholesterol; high fat; low fat
ID C-ELEGANS; CHILD-DEVELOPMENT; OXIDATIVE STRESS; EXPOSURE; DOPAMINE;
   MERCURY; GLUTAMATE; PROTEIN; AGE; NEUROTRANSMISSION
AB Methylmercury (MeHg) is a well-known neurotoxicant; however, its role in metabolic diseases has been gaining wider attention. Chronic exposure to MeHg in human populations shows an association with diabetes mellitus and metabolic syndrome (MS). As the incidences of both obesity and MS are on the rise globally, it is important to understand the potential role of MeHg in the development of the disease. There is a dearth of information on dietary interactions between MeHg and lipids, which play an important role in developing MS. We have previously shown that MeHg increases food seeking behaviors, lipid levels, fat storage, and pro-adipogenic gene expression in C. elegans fed the standard OP50 Escherichia coli diet. However, we hypothesized that these metabolic changes could be prevented if the worms were fed a bacterial diet lower in lipid content. We tested whether C. elegans developed metabolic alterations in response to MeHg if they were fed two alternative E. coli strains (HT115 and HB101) that are known absorb significantly less lipids from their media. Additionally, to explore the effect of a high-lipid and high-cholesterol diet on MeHg-induced metabolic dysfunction, we supplemented the OP50 strain with twice the standard concentration of cholesterol in the nematode growth media. Wild-type worms fed either the HB101 or HT115 diet were more resistant to MeHg than the worms fed the OP50 diet, showing a significant right-hand shift in the dose-response survival curve. Worms fed the OP50 diet supplemented with cholesterol were more sensitive to MeHg, showing a significant left-hand shift in the dose-response survival curve. Changes in sensitivity to MeHg by differential diet were not due to altered MeHg intake in the worms as measured by inductively coupled mass spectrometry. Worms fed the low-fat diets showed protection from MeHg-induced metabolic changes, including decreased food consumption, lower triglyceride content, and lower fat storage than the worms fed either of the higher-fat diets. Oxidative stress is a common characteristic of both MeHg exposure and high-fat diets. Worms fed either OP50 or OP50 supplemented with cholesterol and treated with MeHg had significantly higher levels of reactive oxygen species, carbonylated proteins, and loss of glutathione than the worms fed the HT115 or HB101 low-lipid diets. Taken together, our data suggest a synergistic effect of MeHg and dietary lipid levels on MeHg toxicity and fat metabolism in C. elegans, which may affect the ability of MeHg to cause metabolic dysfunction.
C1 [Crawford, Nicole; Martell, Megan; Nielsen, Tyson; Khalil, Belal; Imtiaz, Farooq; Nguidjo, Etienne; Caito, Samuel W.] Husson Univ, Dept Pharmaceut Sci, Sch Pharm, Bangor, ME 04401 USA.
   [Newell-Caito, Jennifer L.] Univ Maine, Dept Mol & Biomed Sci, Orono, ME 04469 USA.
   [Bornhorst, Julia] Univ Wuppertal, Fac Math & Nat Sci, Food Chem, D-42119 Wuppertal, Germany.
   [Schwerdtle, Tanja] Univ Potsdam, Inst Nutr Sci, Dept Food Chem, D-14558 Potsdam, Germany.
C3 Husson University; University of Maine System; University of Maine
   Orono; University of Wuppertal; University of Potsdam
RP Caito, SW (corresponding author), Husson Univ, Dept Pharmaceut Sci, Sch Pharm, Bangor, ME 04401 USA.
EM crawfordn@husson.edu; martellm@husson.edu; nielsent@husson.edu;
   khalilb@husson.edu; imtiazf@husson.edu; etiennenguidjo08@yahoo.ca;
   jennifer.newellcaito@maine.edu; bornhorst@uni-wuppertal.de;
   tanja.schwerdtle@bfr.bund.de; caitos@husson.edu
RI Crawford, Nicole/Q-7429-2019
OI Newell-Caito, Jennifer/0000-0003-0981-9736; Bornhorst,
   Julia/0000-0002-4018-2406
FU Husson University School of Pharmacy Research Grant; Husson University
   Research Fund Program, DFG Research Unit TraceAge [FOR 2558]
FX This research was funded by the Husson University School of Pharmacy
   Research Grant, Husson University Research Fund Program, DFG Research
   Unit TraceAge (FOR 2558).
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NR 89
TC 12
Z9 12
U1 2
U2 20
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2305-6304
J9 TOXICS
JI Toxics
PD NOV
PY 2021
VL 9
IS 11
AR 287
DI 10.3390/toxics9110287
PG 19
WC Environmental Sciences; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Toxicology
GA XH1FJ
UT WOS:000725186800001
PM 34822679
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Motamed, M
   Nargesi, AA
   Heidari, B
   Mirmiranpour, H
   Esteghamati, A
   Nakhjavani, M
AF Motamed, Mahtab
   Nargesi, Arash A.
   Heidari, Behnam
   Mirmiranpour, Hossein
   Esteghamati, Alireza
   Nakhjavani, Manouchehr
TI Oxidized Low-Density Lipoprotein (ox-LDL) to LDL Ratio (ox-LDL/LDL) and
   ox-LDL to High-Density Lipoprotein Ratio (ox-LDL/HDL): Are they Accurate
   Biomarkers of Type 2 Diabetes Mellitus?
SO CLINICAL LABORATORY
LA English
DT Article
DE type 2 diabetes mellitus; ox-LDL; ox-LDL/LDL; ox-LDL/HDL
ID OXIDATIVE STRESS; ENDOTHELIAL DYSFUNCTION; VASCULAR COMPLICATIONS;
   METABOLIC SYNDROME; CHOLESTEROL RATIO; PLASMA-LEVELS; DETERMINANTS;
   ASSOCIATIONS; PREDICTOR; IMMUNITY
AB Background: Oxidized low-density lipoprotein (ox-LDL) plays a principal role in diabetes complications, though ox-LDL concentrations and its functions are dependents of other oxidative and anti-oxidative particles. The ox-LDL to low-density lipoprotein ratio (ox-LDL/LDL) and ox-LDL to high-density lipoprotein ratio (ox-LDL/HDL) as new lipid biomarkers may serve as a good estimation of oxidation and anti-oxidation in type 2 diabetes mellitus. The aim of this study was first to examine ox-LDL/LDL and ox-LDL/HDL levels in patients with type 2 diabetes mellitus compared to a control group and evaluate their diagnostic accuracies, and, second, to investigate the correlation of these two ratios with triglyceride and HDL levels.
   Methods: This study was included 144 patients admitted to the diabetes clinic of a University general hospital and 41 healthy individuals as controls. Levels of LDL, HDL, triglyceride (TG) ox-LDL, and malondialdehyde (MDA) were measured for all patients. Levels of ox-LDL/LDL and ox-LDL/HDL were calculated. Diagnostic accuracies were determined by receiver-operating characteristic curve analysis by measuring the area under the curve.
   Results: Ox-LDL, ox-LDL/LDL, and ox-LDL/HDL were significantly higher in patients compared to the control group after adjustment for age, gender, and BMI (p = 0.000). The area under the curve for diagnosing diabetes was 0.946 for ox-LDL/HDL, 0.918 for ox-LDL/LDL, and 0.832 for ox-LDL. Ox-LDL/HDL was positively correlated with MDA (r = 0.210, p = 0.011). Ox-LDL/LDL was negatively correlated with HDL (r =-0.2 p = 0.016) and positively correlated with TG (r = 0.45 p = 0.000). Ox-LDL/HDL and TG had significant positive correlation (r = 0.173 p = 0.037). The ox-LDL/LDL level was significantly higher in patients with coronary heart disease (CHD) or hypertension (HTN) compared to those without (p = 0.042).
   Conclusions: Our findings revealed that ox-LDL/LDL and ox-LDL/HDL are potent biomarkers of type 2 diabetes, which apparently reflect the association between lipids in the state of oxidative stress.
C1 [Motamed, Mahtab; Nargesi, Arash A.; Heidari, Behnam; Mirmiranpour, Hossein; Esteghamati, Alireza; Nakhjavani, Manouchehr] Univ Tehran Med Sci, Vali Asr Hosp, EMRC, Tehran, Iran.
C3 Tehran University of Medical Sciences
RP Nakhjavani, M (corresponding author), Univ Tehran Med Sci, Vali Asr Hosp, EMRC, Endocrine & Metab Disorders, POB 13145-784, Tehran, Iran.
EM nakhjavanim@tums.ac.ir
RI Motamed, Mahtab/AAM-6424-2020; Nargesi, Arash/AAM-5298-2020; Nakhjavani,
   Manouchehr/J-3704-2019; Mirmiranpour, Hossein/U-6611-2017
OI Mirmiranpour, Hossein/0000-0001-7666-0900; Esteghamati,
   Alireza/0000-0001-5114-3982
FU Tehran University of Medical Sciences
FX This study was funded by grants provided by the Tehran University of
   Medical Sciences.
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NR 41
TC 11
Z9 11
U1 4
U2 31
PU CLIN LAB PUBL
PI HEIDELBERG
PA IM BREITSPIEL 15, HEIDELBERG, D-69126, GERMANY
SN 1433-6510
J9 CLIN LAB
JI Clin. Lab.
PY 2016
VL 62
IS 9
BP 1609
EP 1617
DI 10.7754/Clin.Lab.2016.150412
PG 9
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA DW0FW
UT WOS:000383317300003
PM 28164576
DA 2025-06-11
ER

PT J
AU Siervo, M
   Hussin, AM
   Calella, P
   Ashor, A
   Shannon, OM
   Mendes, I
   Stephan, BCM
   Zheng, DC
   Hill, T
   Mathers, JC
AF Siervo, Mario
   Hussin, Azizah Mat
   Calella, Patrizia
   Ashor, Ammar
   Shannon, Oliver M.
   Mendes, Ines
   Stephan, Blossom C. M.
   Zheng, Dingchang
   Hill, Tom
   Mathers, John C.
TI Associations between Aging and Vitamin D Status with Whole-Body Nitric
   Oxide Production and Markers of Endothelial Function
SO JOURNAL OF NUTRITION
LA English
DT Article
DE aging; vitamin D; pulse wave velocity; endothelial function; nitric
   oxide
ID OXIDATIVE STRESS; BLOOD-PRESSURE; ASYMMETRIC DIMETHYLARGININE; METABOLIC
   SYNDROME; D SUPPLEMENTATION; HEALTH; DYSFUNCTION; BIOMARKERS; NO
AB Background: Aging and vitamin D deficiency have been associated with reduced nitric oxide (NO) synthesis and impaired endothelial function (EF) but the evidence in humans remains weak. Objectives: Two independent cross-sectional studies were designed to evaluate the association between age, sex, and plasma vitamin D concentrations with physiological and biochemical biomarkers of NO synthesis and EF in young and older healthy participants (Study 1) and in overweight and obese postmenopausal females (Study 2). Methods: In Study 1, 40 young (20-49 y) and older (50-75 y) males and females (10 participants per age and sex group) were included. Resting blood pressure and ear -to -finger peripheral pulse wave velocity (PWV) were measured. A stable-isotopic method was used to determine whole-body NO production. Plasma 25-hydroxyvitamin D (25(OH)D), nitrate, nitrite, and asymmetric dimethylarginine (ADMA) concentrations were determined. In Study 2, 80 older overweight and obese females (age 61.2 +/- 6.2 y, body mass index 29.5 +/- 4.4 kg/m2) were recruited. Postocclusion reactive hyperemia (PORH) and peripheral PWV were measured. Plasma concentrations of 25(OH)D, nitrate, cyclic guanosine monophosphate, 3-nitrotyrosine (3 -NT), endothelin-1, vascular endothelial growth factor, and ADMA were determined. Results: In Study 1, whole-body NO production was significantly greater in young compared with older participants (0.61 +/- 0.30 mu mol.h-1.kg-1 compared with 0.39 +/- 0.10 mu mol.h-1.kg-1, P = 0.01) but there was no evidence of a sex difference (P = 0.81). Plasma 25(OH)D concentration was not associated with PWV (r = 0.18, P = 0.28) or whole-body NO production (r = -0.20, P = 0.22). Plasma ADMA concentration was associated positively with age (r = 0.35, P = 0.03) and negatively with whole-body NO production (r = -0.33, P = 0.04). In Study 2, age was associated with lower PORH (r = -0.28, P = 0.02) and greater ADMA concentrations (r = 0.22, P = 0.04). Plasma 25(OH)D concentration was inversely associated with 3 -NT concentrations (r = -0.31, P = 0.004). Conclusions: Older age was associated with lower whole-body NO production. Plasma vitamin D concentrations were not associated with NO production or markers of EF but showed a weak, significant correlation with oxidative stress in postmenopausal overweight females.
C1 [Siervo, Mario] Curtin Univ, Sch Populat Hlth, Perth, WA, Australia.
   [Siervo, Mario; Stephan, Blossom C. M.] Curtin Univ, Enable Inst, Curtin Dementia Ctr Excellence, Perth, WA, Australia.
   [Hussin, Azizah Mat; Shannon, Oliver M.; Mendes, Ines; Hill, Tom; Mathers, John C.] Newcastle Univ, Populat Hlth Sci Inst, Human Nutr & Exercise Res Ctr, Ctr Healthier Lives, Newcastle Upon Tyne, England.
   [Hussin, Azizah Mat] Univ Kuala Lumpur, Inst Med Sci Technol, Kuala Lumpur, Malaysia.
   [Calella, Patrizia] Univ Naples Parthenope, Dept Movement Sci & Wellbeing, Naples, Italy.
   [Ashor, Ammar] Univ Al Mustansiriyah, Coll Med, Dept Internal Med, Baghdad, Iraq.
   [Zheng, Dingchang] Coventry Univ, Res Ctr Intelligent Hlth care, Coventry, England.
C3 Curtin University; Curtin University; Newcastle University - UK;
   University of Kuala Lumpur; Parthenope University Naples; Mustansiriya
   University; Coventry University
RP Siervo, M (corresponding author), Curtin Univ, Sch Populat Hlth, Perth, WA, Australia.
EM mario.siervo@curtin.edu.au
RI Zhang, Zhiyong/KPY-6346-2024; Siervo, Mario/LIG-2137-2024; Stephan,
   Blossom/A-1560-2009; Ashor, Ammar/A-9094-2013; Mathers,
   Jonathan/ABE-1164-2021; Calella, Patrizia/Q-2984-2019
OI Zheng, Dingchang/0000-0001-8077-4548; Siervo, Mario/0000-0001-5515-0944
FU MRC [MR/P020941/1] Funding Source: UKRI
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NR 45
TC 2
Z9 2
U1 0
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0022-3166
EI 1541-6100
J9 J NUTR
JI J. Nutr.
PD FEB
PY 2024
VL 154
IS 2
BP 469
EP 478
DI 10.1016/j.tjnut.2023.12.002
EA FEB 2024
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA LR1U8
UT WOS:001188445900001
PM 38048992
OA Bronze
DA 2025-06-11
ER

PT J
AU Ge, CX
   Xu, MX
   Qin, YT
   Gu, TT
   Lou, DS
   Li, Q
   Hu, LF
   Nie, XY
   Wang, MX
   Tan, J
AF Ge, Chenxu
   Xu, Minxuan
   Qin, Yuting
   Gu, Tingting
   Lou, Deshuai
   Li, Qiang
   Hu, Linfeng
   Nie, Xuyuan
   Wang, Mingxing
   Tan, Jun
TI Fisetin supplementation prevents high fat diet-induced diabetic
   nephropathy by repressing insulin resistance and RIP3-regulated
   inflammation
SO FOOD & FUNCTION
LA English
DT Article
ID NF-KAPPA-B; CHRONIC KIDNEY-DISEASE; FLAVONOID FISETIN; OXIDATIVE STRESS;
   NLRP3 INFLAMMASOME; RENAL INJURY; METABOLIC SYNDROME; MOLECULE-1 KIM-1;
   CELL-DEATH; MICE
AB Obesity-related renal disease is related to caloric excess promoting deleterious cellular responses. However, a full understanding of the molecular mechanisms involved in progressive kidney disease, as well as a therapeutic strategy, is still absent. Fisetin (FIS), as a natural flavonoid, possesses various bioactivities in a number of disease models. However, its role in obesity-associated kidney injury is still unclear and requires elucidation. In our study, an obesity animal model was established using C57BL/6 mice fed with a normal chow diet (NCD) or high fat diet (HFD) for 16 weeks with or without FIS administration (20, 40 or 80 mg kg(-1)). Our results indicated that chronic HFD feeding led to a significant body weight gain in mice compared to the normal control group, accompanied by a marked insulin resistance and glucose intolerance, whereas FIS treatment exerted prominently protective effects. In addition, FIS significantly attenuated HFD-induced histological alterations in renal tissue samples. Moreover, FIS treatment down-regulated expression of kidney injury molecule-1 (KIM-1), and up-regulated nephrin and podocin expression levels in the kidneys of HFD-fed mice, improving their renal dysfunction. After HFD feeding, mice treated with FIS exhibited a decrease in phosphorylated IRS1(Ser307), and an increase in phosphorylated glycogen synthase kinase 1 (IRS1(Tyr608)), AKT, forkhead box protein O1 (FOXO1) and glycogen synthase kinase (GSK)-3. Furthermore, FIS administration markedly restrained the inflammatory response in the kidneys of HFD-challenged mice, as evidenced by the reduced pro-inflammatory cytokines, tumor necrosis factor- (TNF-), interleukin 6 (IL-6), IL-1 and IL-18, which was attributed to the blockage of nuclear factor B (NF-B) signaling. Importantly, FIS-treated obese mice exerted a remarkable decrease in RIP3 expressions in the kidneys compared to obese mice in the absence of FIS, along with an evident reduction in the NOD-like receptor protein 3 (NLRP3), an apoptosis-associated speck-like protein containing a Caspase recruitment domain (ASC) and Caspase-1. The protective effects of FIS against HFD-induced renal injury were verified in vitro using palmitate (PAL)-treated HK2 cells, an immortalized proximal tubule epithelial cell line from the adult human kidney. In summary, our results supported the notion that FIS functions as a promising agent to improve insulin resistance and inflammatory response against metabolic stress-induced renal injury.
C1 [Ge, Chenxu; Xu, Minxuan; Lou, Deshuai; Li, Qiang; Hu, Linfeng; Nie, Xuyuan; Tan, Jun] Chongqing Univ Educ, Sch Biol & Chem Engn, Chongqing Key Lab Med Resources Three Gorges Rese, Chongqing 400067, Peoples R China.
   [Ge, Chenxu; Xu, Minxuan; Lou, Deshuai; Li, Qiang; Hu, Linfeng; Nie, Xuyuan; Tan, Jun] Chongqing Univ Educ, Res Ctr Brain Intellectual Promot & Dev Children, Chongqing 400067, Peoples R China.
   [Qin, Yuting] Ocean Univ China, Sch Med & Pharm, Qingdao 266100, Shandong, Peoples R China.
   [Gu, Tingting] Nanjing Univ, Coll Engn & Appl Sci, Nanjing 210023, Jiangsu, Peoples R China.
   [Wang, Mingxing] Luoyang Normal Univ, Coll Food & Drug, Luoyang 471934, Peoples R China.
C3 Chongqing University of Education; Chongqing University of Education;
   Ocean University of China; Nanjing University; Luoyang Normal University
RP Xu, MX; Tan, J (corresponding author), Chongqing Univ Educ, Sch Biol & Chem Engn, Chongqing Key Lab Med Resources Three Gorges Rese, Chongqing 400067, Peoples R China.; Xu, MX; Tan, J (corresponding author), Chongqing Univ Educ, Res Ctr Brain Intellectual Promot & Dev Children, Chongqing 400067, Peoples R China.
EM minxuanxu@foxmail.com; tanjunmail@126.com
RI hu, linfeng/C-6491-2014
OI Xu, Minxuan/0000-0002-0742-4717
FU National Natural Science Foundation of China (NSFC) [81703527];
   Chongqing Research Program of Basic Research and Frontier Technology
   [cstc2017jcyjAX0356, cstc2018jcyjA3686, cstc2018jcyjA1472,
   cstc2018jcyjA3533]; School-level Research Program of Chongqing
   University of Education [KY201710B, 17GZKP01]; Advanced Programs of
   Post-doctor of Chongqing [2017LY39]
FX This work was supported by National Natural Science Foundation of China
   (NSFC Grant: 81703527); Chongqing Research Program of Basic Research and
   Frontier Technology (Grant: cstc2017jcyjAX0356, cstc2018jcyjA3686,
   cstc2018jcyjA1472 and cstc2018jcyjA3533); School-level Research Program
   of Chongqing University of Education (Grant: KY201710B and 17GZKP01) and
   Advanced Programs of Post-doctor of Chongqing (Grant: 2017LY39).
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NR 79
TC 47
Z9 48
U1 1
U2 29
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PD MAY 1
PY 2019
VL 10
IS 5
BP 2970
EP 2985
DI 10.1039/c8fo01653d
PG 16
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA HZ8ZR
UT WOS:000469145900061
PM 31074472
DA 2025-06-11
ER

PT J
AU Eid, SA
   O'Brien, PD
   Hinder, LM
   Hayes, JM
   Mendelson, FE
   Zhang, HY
   Zeng, LX
   Kretzler, K
   Narayanan, S
   Abcouwer, SF
   Brosius, FC
   Pennathur, S
   Savelieff, MG
   Feldman, EL
AF Eid, Stephanie A.
   O'Brien, Phillipe D.
   Hinder, Lucy M.
   Hayes, John M.
   Mendelson, Faye E.
   Zhang, Hongyu
   Zeng, Lixia
   Kretzler, Katharina
   Narayanan, Samanthi
   Abcouwer, Steven F.
   Brosius, Frank C., III
   Pennathur, Subramaniam
   Savelieff, Masha G.
   Feldman, Eva L.
TI Differential Effects of Empagliflozin on Microvascular Complications in
   Murine Models of Type 1 and Type 2 Diabetes
SO BIOLOGY-BASEL
LA English
DT Article
DE diabetic neuropathy; diabetic retinopathy; diabetic kidney disease;
   empagliflozin; oxidative stress
ID INSULIN-RESISTANCE; METABOLIC SYNDROME; KIDNEY-DISEASE; MOUSE MODELS;
   INHIBITOR; NEPHROPATHY; IMPROVES; PLACEBO; OBESITY; GROWTH
AB Simple Summary
   Type 1 and type 2 diabetes can lead to serious health problems that affect many organs including the nerve, the eye, and the kidney. These health problems can be disabling or even life-threatening, and to date, there are no effective therapies that can slow or prevent their development. We studied the effect of empagliflozin, a medication that reduces blood sugar levels and the risk of cardiovascular disease, on the nerve, eye, and kidney in a side-by-side comparison of type 1 and type 2 mouse models. Empagliflozin had no beneficial effects on disease progression in type 2 diabetic mice, but improved nerve function in the type 1 diabetic model, an effect that was accompanied by reduced markers of oxidative injury. These findings support the concept that different mechanisms contribute to nerve damage in type 1 and type 2 diabetes. Our results further support our view that the concept of one therapy will benefit all complications should be abandoned as we pursue more personalized, tissue-specific, diabetes type-specific treatments.
   Microvascular complications account for the significant morbidity associated with diabetes. Despite tight glycemic control, disease risk remains especially in type 2 diabetes (T2D) patients and no therapy fully prevents nerve, retinal, or renal damage in type 1 diabetes (T1D) or T2D. Therefore, new antidiabetic drug classes are being evaluated for the treatment of microvascular complications. We investigated the effect of empagliflozin (EMPA), an inhibitor of the sodium/glucose cotransporter 2 (SGLT2), on diabetic neuropathy (DPN), retinopathy (DR), and kidney disease (DKD) in streptozotocin-induced T1D and db/db T2D mouse models. EMPA lowered blood glycemia in T1D and T2D models. However, it did not ameliorate any microvascular complications in the T2D model, which was unexpected, given the protective effect of SGLT2 inhibitors on DKD progression in T2D subjects. Although EMPA did not improve DKD in the T1D model, it had a potential modest effect on DR measures and favorably impacted DPN as well as systemic oxidative stress. These results support the concept that glucose-centric treatments are more effective for DPN in T1D versus T2D. This is the first study that provides an evaluation of EMPA treatment on all microvascular complications in a side-by-side comparison in T1D and T2D models.
C1 [Eid, Stephanie A.; O'Brien, Phillipe D.; Hinder, Lucy M.; Hayes, John M.; Mendelson, Faye E.; Kretzler, Katharina; Narayanan, Samanthi; Savelieff, Masha G.; Feldman, Eva L.] Univ Michigan, Dept Neurol, Ann Arbor, MI 48109 USA.
   [Zhang, Hongyu; Zeng, Lixia; Brosius, Frank C., III; Pennathur, Subramaniam] Univ Michigan, Dept Internal Med, Div Nephrol, Ann Arbor, MI 48109 USA.
   [Abcouwer, Steven F.] Univ Michigan, Dept Ophthalmol & Visual Sci, Ann Arbor, MI 48105 USA.
   [Brosius, Frank C., III; Pennathur, Subramaniam] Univ Michigan, Dept Mol, Ann Arbor, MI 48109 USA.
   [Brosius, Frank C., III; Pennathur, Subramaniam] Univ Michigan, Dept Integrat Physiol, Ann Arbor, MI 48109 USA.
C3 University of Michigan System; University of Michigan; University of
   Michigan System; University of Michigan; University of Michigan System;
   University of Michigan; University of Michigan System; University of
   Michigan; University of Michigan System; University of Michigan
RP Feldman, EL (corresponding author), Univ Michigan, Dept Neurol, Ann Arbor, MI 48109 USA.
EM steid@med.umich.edu; phillipe.obrien@gmail.com; lucyhinder@gmail.com;
   jmhayes@med.umich.edu; fayemend@med.umich.edu; hyzhang@umich.edu;
   lixiaze@med.umich.edu; kkathari@umich.edu; sami.narayanan@gmail.com;
   sabcouwe@med.umich.edu; fbrosius@umich.edu; spennath@umich.edu;
   savelief@umich.edu; efeldman@med.umich.edu
RI Pennathur, Subramaniam/O-7032-2017; O'Brien, Phillipe/W-4268-2019
OI Pennathur, Subramaniam/0000-0003-3628-6883; Abcouwer, Steven
   F/0000-0003-2580-1288; Kretzler, Katharina H/0000-0003-3042-814X;
   Hinder, Lucy/0000-0002-5206-8010
FU National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
   of the National Institutes of Health (NIH) [U2CDK110768]; NIH
   [1R24082841, R21NS102924, P30DK081943, R01EY020582, P30EY007003]; Novo
   Nordisk Foundation [NNF14OC0011633]; Nathan and Rose Milstein Research
   Fund; Sinai Medical Staff Foundation Neuroscience Scholar Fund;
   NeuroNetwork for Emerging Therapies; A. Alfred Taubman Medical Research
   Institute; National Institute of Diabetes and Digestive and Kidney
   Diseases [U2CDK110768] Funding Source: NIH RePORTER
FX This research work used the Cincinnati MMPC for serum lipid profiles
   measurements (DK059630). Research reported in this publication was also
   made possible by Core Services supported by the National Institute of
   Diabetes and Digestive and Kidney Diseases (NIDDK) of the National
   Institutes of Health (NIH) under award number U2CDK110768 (Michigan
   MMPC). Funding was provided by the NIH (1R24082841 to E.L.F., S.F.A.,
   F.C.B., S.P.; R21NS102924 to E.L.F.; P30DK081943 to S.P.; R01EY020582 to
   S.F.A.; P30EY007003 Kellogg Eye Center Core Center for Vision Research);
   Novo Nordisk Foundation (NNF14OC0011633 to E.L.F.); Nathan and Rose
   Milstein Research Fund to S.A.E.; Sinai Medical Staff Foundation
   Neuroscience Scholar Fund (E.L.F.); NeuroNetwork for Emerging Therapies;
   the A. Alfred Taubman Medical Research Institute.
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NR 50
TC 26
Z9 28
U1 0
U2 1
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2079-7737
J9 BIOLOGY-BASEL
JI Biology-Basel
PD NOV
PY 2020
VL 9
IS 11
AR 347
DI 10.3390/biology9110347
PG 14
WC Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics
GA OW2QQ
UT WOS:000592738500001
PM 33105667
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Dobbelaar, P
   Bouwstra, RJ
   Goselink, RMA
   Jorritsma, R
   van den Borne, JJGC
   Jansen, EHJM
AF Dobbelaar, P.
   Bouwstra, R. J.
   Goselink, R. M. A.
   Jorritsma, R.
   van den Borne, J. J. G. C.
   Jansen, E. H. J. M.
TI Effects of vitamin E supplementation on and the association of body
   condition score with changes in peroxidative biomarkers and antioxidants
   around calving in dairy heifers
SO JOURNAL OF DAIRY SCIENCE
LA English
DT Article
DE body condition score; dairy cow; oxidative status; vitamin E
ID OXIDATIVE STRESS; PERIPARTURIENT PERIOD; IN-VITRO; SUPEROXIDE-DISMUTASE;
   METABOLIC SYNDROME; FOLLICULAR-FLUID; IMMUNE FUNCTION; OXIDANT STRESS;
   FATTY-ACIDS; MILK-YIELD
AB The objective of this study was to investigate the effect of vitamin E supplementation on oxidative status in blood, liver, milk, and ovarian follicular fluid in periparturient heifers. Vitamin E supplementation started 8 wk before calving and continued until 8 wk postpartum. Grass silage was the main forage fed during the experiment. In addition, supplemented heifers (n = 9) received 3,000 IU of vitamin E daily on a carrier food; control heifers (n = 9) consumed only the carrier food. Blood samples and liver biopsies were taken frequently throughout the study and ovarian follicular fluid was sampled at 8 wk postpartum. Body condition score was scored weekly and milk yield was measured daily. A marker of oxidative damage, determinable reactive oxygen metabolites (d-ROM), and a set of antioxidants were measured in blood, liver, milk, and ovarian follicular fluid. Control heifers had a low vitamin E status, and selenium status was marginal in control and supplemented heifers. Vitamin E supplementation increased vitamin E concentrations in blood, liver, and ovarian follicular fluid and increased triacylglycerol in liver. Serum d-ROM were not reduced by vitamin E supplementation. Superoxide dismutase and glutathione peroxidase activity in red blood cells and liver and glutathione peroxidase activity in ovarian follicular fluid were not affected by vitamin E supplementation and they were not increased around calving. Protein thiol groups and ratio of reduced glutathione to oxidized glutathione were also not increased around calving. These results suggest that heifers around calving experience a low level of oxidative processes. This might be caused by lower than expected milk production attributed to a low forage intake. Serum d-ROM were negatively correlated with protein thiol groups and positively correlated with the activity of glutathione peroxidase in red blood cells, oxidized glutathione, and the ratio of reduced glutathione and oxidized glutathione in serum. The lack of treatment effects allowed estimation of the effects of body condition 4 wk before calving and the loss of body condition on markers of lipid peroxidation and antioxidants. A trend that a body condition of >= 3 might result in more oxidative damage measured by serum d-ROM was observed, but fatter heifers had a significantly higher ratio of reduced glutathione to oxidized glutathione.
C1 [Dobbelaar, P.; Bouwstra, R. J.; Jorritsma, R.] Univ Utrecht, Fac Vet Med, Dept Farm Anim Hlth, NL-3508 TD Utrecht, Netherlands.
   [Goselink, R. M. A.] Wageningen UR Livestock Res, NL-8200 AB Lelystad, Netherlands.
   [van den Borne, J. J. G. C.] Wageningen Univ, Anim Nutr Grp, NL-6700 AH Wageningen, Netherlands.
   [Jansen, E. H. J. M.] Natl Inst Publ Hlth & Environm, NL-3720 BA Bilthoven, Netherlands.
C3 Utrecht University; Wageningen University & Research; Wageningen
   University & Research; Netherlands National Institute for Public Health
   & the Environment
RP Dobbelaar, P (corresponding author), Univ Utrecht, Fac Vet Med, Dept Farm Anim Hlth, POB 80-151, NL-3508 TD Utrecht, Netherlands.
EM p.dobbelaar@uu.nl
FU Product Board Animal Feed (The Hague, the Netherlands)
FX The authors gratefully acknowledge the Product Board Animal Feed (The
   Hague, the Netherlands) for funding this experiment, P. L. A. M. Vos
   (Department of Farm Animal Health, Utrecht University) for assisting in
   follicular fluid collection, and H. Cremers and P. Beekhof (The National
   Institute for Public Health and Environment, Bilthoven, the Netherlands)
   for their technical assistance.
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   [No title captured]
NR 59
TC 22
Z9 29
U1 1
U2 18
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0022-0302
J9 J DAIRY SCI
JI J. Dairy Sci.
PD JUL
PY 2010
VL 93
IS 7
BP 3103
EP 3113
DI 10.3168/jds.2009-2677
PG 11
WC Agriculture, Dairy & Animal Science; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture; Food Science & Technology
GA 614AI
UT WOS:000279026800030
PM 20630228
OA Bronze
DA 2025-06-11
ER

PT J
AU Gopal, T
   Kumar, N
   Perriotte-Olson, C
   Casey, CA
   Donohue, TM
   Harris, EN
   Talmon, G
   Kabanov, AV
   Saraswathi, V
AF Gopal, Thiyagarajan
   Kumar, Narendra
   Perriotte-Olson, Curtis
   Casey, Carol A.
   Donohue, Terrence M., Jr.
   Harris, Edward N.
   Talmon, Geoffrey
   Kabanov, Alexander, V
   Saraswathi, Viswanathan
TI Nanoformulated SOD1 ameliorates the combined NASH and alcohol-associated
   liver disease partly via regulating CYP2E1 expression in adipose tissue
   and liver
SO AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
LA English
DT Article
DE AALD; catalase; cytochrome P450 2E1; ethanol; superoxide dismutase
ID INSULIN-RESISTANCE; CHRONIC ETHANOL; NONALCOHOLIC STEATOHEPATITIS;
   CYTOCHROME-P450 2E1; METABOLIC SYNDROME; OXIDATIVE STRESS; RISK-FACTORS;
   FATTY-ACIDS; INJURY; INFLAMMATION
AB Enhanced free fatty acid (FFA) flux from adipose tissue (AT) to liver plays an important role in the development of nonalcoholic steatohepatitis (NASH) and alcohol-associated liver disease (AALD). We determined the effectiveness of nanoformulated superoxide dismutase 1 (Nano) in attenuating liver injury in a mouse model exhibiting a combination of NASH and AALD. Male C57BL6/J mice were fed a chow diet (CD) or a high-fat diet (HF) for 10 wk followed by pair feeding of the Lieber-DeCarli control (control) or ethanol (ET) diet for 4 wk. Nano was administered once every other day for the last 2 wk of ET feeding. Mice were divided into I) CD + control diet (CI) + Corr), 2) high-fat diet (HF) + control diet (HF + Cont), 3) HF + Cont + Nano, 4) HF + ET diet (HF + ET), and 5) I IF + ET + Nano. The total fat mass, visceral AT mass (VAT). and VAT perilipin 1 content were significantly lower only in HF + ET-fed mice but not in HF + ET + Nano-treated mice compared with controls. The HF + ET-fed mice showed an upregulation of VAT CYP2E1 protein. and Nano abrogated this effect. We noted a significant rise in plasma FFAs. ALT, and monocyte chemoattractant protein-1 in HF + ET-fed mice, which was blunted in HF + ET + Nano-treated mice. IlF + ET-induced increases in hepatic steatosis and inflammatory markers were attenuated upon Nano treatment. Nano reduced hepatic CYP2E1 and enhanced catalase levels in HF + ET-fed mice with a concomitant increase in SOD1 protein and activity in liver. Nano was effective in attenuating AT and liver injury in mice exhibiting a combination of NASH and AALD, partly via reduced CYP2E1-mediated ET metabolism in these organs.
   NEW & NOTEWORTHY Increased free fatty acid flux from adipose tissue (AT) to liver accompanied by oxidative stress promotes nonalcoholic steatobepatitis (NASII) and alcohol-associated liver injury (AALD). Obesity increases the severity of AALD. Using a two-hit model involving a high-fat diet and chronic ethanol feeding to mice, and treating them with nanoformulated superoxide dismutase (nanoSOD), we have shown that nanoSOD improves AT lipid storage, reduces CYP2E1 in AT and liver, and attenuates the combined NASH/AALD in mice.
C1 [Gopal, Thiyagarajan; Kumar, Narendra; Perriotte-Olson, Curtis; Saraswathi, Viswanathan] Univ Nebraska Med Ctr, Dept Internal Med, Div Diabet Endocrinol & Metab, Omaha, NE USA.
   [Casey, Carol A.; Donohue, Terrence M., Jr.] Univ Nebraska Med Ctr, Dept Internal Med, Div Gastroenterol & Hepatol, Omaha, NE USA.
   [Casey, Carol A.; Donohue, Terrence M., Jr.; Saraswathi, Viswanathan] Vet Affairs Nebraska Western Iowa Hlth Care Syst, Omaha, NE 68105 USA.
   [Harris, Edward N.] Univ Nebraska, Dept Biochem, Lincoln, NE 68583 USA.
   [Talmon, Geoffrey] Univ Nebraska Med Ctr, Dept Pathol & Microbiol, Omaha, NE USA.
   [Kabanov, Alexander, V] Univ N Carolina, Eshelman Sch Pharm, Div Pharmacoengn & Mol Pharmaceut, Chapel Hill, NC 27515 USA.
C3 University of Nebraska System; University of Nebraska Medical Center;
   University of Nebraska System; University of Nebraska Medical Center; US
   Department of Veterans Affairs; Veterans Health Administration (VHA); VA
   Nebraska-Western Iowa Health Care System; University of Nebraska System;
   University of Nebraska Lincoln; University of Nebraska System;
   University of Nebraska Medical Center; University of North Carolina;
   University of North Carolina Chapel Hill
RP Saraswathi, V (corresponding author), VA Nebraska Western Iowa Hlth Care Syst, Res Serv, Omaha, NE 68105 USA.
EM s.viswanathan@unmc.edu
RI Kabanov, Alexander/N-3356-2013; Thiyagarajan, Gopal/AFO-0731-2022
OI Thiyagarajan, Gopal/0000-0003-1031-6300
FU National Institute on Alcohol Abuse and Alcoholism (NIAAA)
   [R21-AA-025445]; NIAAA [R21-AA-027367]; National Cancer Institute
   [R21-CA-238953]; Nebraska Research Initiatives; University of North
   Carolina at Chapel Hill Eshelman School of Pharmacy; University Cancer
   Research Fund through the Lineberger Comprehensive Cancer Center
FX This project was supported by National Institute on Alcohol Abuse and
   Alcoholism (NIAAA) Grant R21-AA-025445. V. Saraswathi is also supported
   by NIAAA Grant R21-AA-027367) and National Cancer Institute Grant
   R21-CA-238953 and a seed grant from Nebraska Research Initiatives. A. V.
   Kabanov was partly supported by Carolina Partnership, a strategic
   partnership between the University of North Carolina at Chapel Hill
   Eshelman School of Pharmacy and the University Cancer Research Fund
   through the Lineberger Comprehensive Cancer Center. This study is the
   result of work conducted with the resources and the facilities at the
   Veterans Afffairs Nebraska-Western Iowa Health Care System (Omaha, NE).
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NR 49
TC 21
Z9 23
U1 4
U2 20
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0193-1857
EI 1522-1547
J9 AM J PHYSIOL-GASTR L
JI Am. J. Physiol.-Gastroint. Liver Physiol.
PD MAR
PY 2020
VL 318
IS 3
BP G428
EP G438
DI 10.1152/ajpgi.00217.2019
PG 11
WC Gastroenterology & Hepatology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Physiology
GA KY5TW
UT WOS:000522636400006
PM 31928222
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Murthy, VL
   Naya, M
   Taqueti, VR
   Foster, CR
   Gaber, M
   Hainer, J
   Dorbala, S
   Blankstein, R
   Rimoldi, O
   Camici, PG
   Di Carli, MF
AF Murthy, Venkatesh L.
   Naya, Masanao
   Taqueti, Viviany R.
   Foster, Courtney R.
   Gaber, Mariya
   Hainer, Jon
   Dorbala, Sharmila
   Blankstein, Ron
   Rimoldi, Ornella
   Camici, Paolo G.
   Di Carli, Marcelo F.
TI Effects of Sex on Coronary Microvascular Dysfunction and Cardiac
   Outcomes
SO CIRCULATION
LA English
DT Article
DE atherosclerosis; blood flow velocity; microcirculation; sex; women
ID MYOCARDIAL BLOOD-FLOW; ARTERY-DISEASE; POSTMENOPAUSAL WOMEN;
   GENDER-DIFFERENCES; PROGNOSTIC VALUE; NATIONAL-HEART; RISK-FACTORS;
   CHEST PAIN; SYNDROME-X; RESERVE
AB Background Coronary microvascular dysfunction (CMD) is a prevalent and prognostically important finding in patients with symptoms suggestive of coronary artery disease. The relative extent to which CMD affects both sexes is largely unknown.
   Methods and Results We investigated 405 men and 813 women who were referred for evaluation of suspected coronary artery disease with no previous history of coronary artery disease and no visual evidence of coronary artery disease on rest/stress positron emission tomography myocardial perfusion imaging. Coronary flow reserve was quantified, and coronary flow reserve <2.0 was used to define the presence of CMD. Major adverse cardiac events, including cardiac death, nonfatal myocardial infarction, late revascularization, and hospitalization for heart failure, were assessed in a blinded fashion over a median follow-up of 1.3 years (interquartile range, 0.5-2.3 years). CMD was highly prevalent both in men and women (51% and 54%, respectively; Fisher exact test =0.39; equivalence P=0.0002). Regardless of sex, coronary flow reserve was a powerful incremental predictor of major adverse cardiac events (hazard ratio, 0.80 [95% confidence interval, 0.75-086] per 10% increase in coronary flow reserve; P<0.0001) and resulted in favorable net reclassification improvement (0.280 [95% confidence interval, 0.049-0.512]), after adjustment for clinical risk and ventricular function. In a subgroup (n=404; 307 women/97 men) without evidence of coronary artery calcification on gated computed tomography imaging, CMD was common in both sexes, despite normal stress perfusion imaging and no coronary artery calcification (44% of men versus 48% of women; Fisher exact test P=0.56; equivalence P=0.041).
   Conclusions CMD is highly prevalent among at-risk individuals and is associated with adverse outcomes regardless of sex. The high prevalence of CMD in both sexes suggests that it may be a useful target for future therapeutic interventions.
C1 [Murthy, Venkatesh L.] Univ Michigan, Dept Internal Med, Div Cardiovasc Med, Ann Arbor, MI 48109 USA.
   [Murthy, Venkatesh L.] Univ Michigan, Div Nucl Med, Dept Radiol, Ann Arbor, MI 48109 USA.
   [Murthy, Venkatesh L.] Univ Michigan, Dept Radiol, Div Cardiothorac Imaging, Ann Arbor, MI 48109 USA.
   [Murthy, Venkatesh L.; Naya, Masanao; Taqueti, Viviany R.; Dorbala, Sharmila; Blankstein, Ron; Di Carli, Marcelo F.] Brigham & Womens Hosp, Noninvas Cardiovasc Imaging Program, Dept Internal Med, Boston, MA 02115 USA.
   [Murthy, Venkatesh L.; Naya, Masanao; Taqueti, Viviany R.; Dorbala, Sharmila; Blankstein, Ron; Di Carli, Marcelo F.] Brigham & Womens Hosp, Noninvas Cardiovasc Imaging Program, Dept Radiol, Boston, MA 02115 USA.
   [Murthy, Venkatesh L.; Taqueti, Viviany R.; Hainer, Jon; Dorbala, Sharmila; Blankstein, Ron; Di Carli, Marcelo F.] Brigham & Womens Hosp, Div Cardiovasc Med, Dept Med, Boston, MA 02115 USA.
   [Foster, Courtney R.; Gaber, Mariya; Hainer, Jon; Dorbala, Sharmila; Di Carli, Marcelo F.] CNR, Div Nucl Med & Mol Imaging, Dept Radiol, Milan, Italy.
   [Rimoldi, Ornella] CNR, Ist Bioimmagini & Fisiol Mol, Milan, Italy.
   [Camici, Paolo G.] Ist Sci San Raffaele, I-20132 Milan, Italy.
   [Camici, Paolo G.] Univ Vita Salute San Raffaele, Div Cardiol, Milan, Italy.
C3 University of Michigan System; University of Michigan; University of
   Michigan System; University of Michigan; University of Michigan System;
   University of Michigan; Harvard University; Harvard University Medical
   Affiliates; Brigham & Women's Hospital; Harvard University; Harvard
   University Medical Affiliates; Brigham & Women's Hospital; Harvard
   University; Harvard University Medical Affiliates; Brigham & Women's
   Hospital; Consiglio Nazionale delle Ricerche (CNR); Consiglio Nazionale
   delle Ricerche (CNR); Istituto di Bioimmagini e Fisiologia Molecolare
   (IBFM-CNR); Vita-Salute San Raffaele University; IRCCS Ospedale San
   Raffaele; Vita-Salute San Raffaele University
RP Di Carli, MF (corresponding author), Brigham & Womens Hosp, ASB L1 037-C,75 Francis St, Boston, MA 02115 USA.
EM mdicarli@partners.org
RI Blankstein, Ron/HCH-3241-2022; Rimoldi, Ornella/ABH-5358-2020; Camici,
   Paolo/AAN-1959-2020; Murthy, Venkatesh/B-3448-2013
OI Hainer, Jon/0000-0002-0572-912X; Murthy, Venkatesh/0000-0002-7901-1321
FU National Institutes of Health [T32 HL094301-01A1]
FX The study was funded in part by a training grant from the National
   Institutes of Health (T32 HL094301-01A1).
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NR 45
TC 451
Z9 478
U1 4
U2 48
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0009-7322
EI 1524-4539
J9 CIRCULATION
JI Circulation
PD JUN 17
PY 2014
VL 129
IS 24
BP 2518
EP 2527
DI 10.1161/CIRCULATIONAHA.113.008507
PG 10
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA AJ5ET
UT WOS:000337705900010
PM 24787469
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Mauro, CR
   Tao, M
   Yu, P
   Treviño-Villerreal, JH
   Longchamp, A
   Kristal, BS
   Ozaki, CK
   Mitchell, JR
AF Mauro, Christine R.
   Tao, Ming
   Yu, Peng
   Trevino-Villerreal, J. Humberto
   Longchamp, Alban
   Kristal, Bruce S.
   Ozaki, C. Keith
   Mitchell, James R.
TI Preoperative dietary restriction reduces intimal hyperplasia and
   protects from ischemia-reperfusion injury
SO JOURNAL OF VASCULAR SURGERY
LA English
DT Article
ID CALORIC RESTRICTION; RHESUS-MONKEYS; ISCHEMIA/REPERFUSION INJURY;
   METABOLIC SYNDROME; MORTALITY; MICE; RESPONSES; IMPACTS; DISEASE;
   PATENCY
AB Objective: Whereas chronic overnutrition is a risk factor for surgical complications, long-term dietary restriction (reduced food intake without malnutrition) protects in preclinical models of surgical stress. Building on the emerging concept that acute preoperative dietary perturbations can affect the body's response to surgical stress, we hypothesized that short-term high-fat diet (HFD) feeding before surgery is detrimental, whereas short-term nutrient/energy restriction before surgery can reverse negative outcomes. We tested this hypothesis in two distinct murine models of vascular surgical injury, ischemia-reperfusion (IR) and intimal hyperplasia (IH).
   Methods: Short-term overnutrition was achieved by feeding mice a HFD consisting of 60% calories from fat for 2 weeks. Short-term dietary restriction consisted of either 1 week of restricted access to a protein-free diet (protein/energy restriction) or 3 days of water-only fasting immediately before surgery; after surgery, all mice were given ad libitum access to a complete diet. To assess the impact of preoperative nutrition on surgical outcome, mice were challenged in one of two fundamentally distinct surgical injury models: IR injury to either kidney or liver, or a carotid focal stenosis model of IH.
   Results: Three days of fasting or 1 week of preoperative protein/energy restriction attenuated IH development measured 28 days after focal carotid stenosis. One week of preoperative protein/energy restriction also reduced plasma urea, creatinine, and damage to the corticomedullary junction after renal IR and decreased aspartate transaminase, alanine transaminase, and hemorrhagic necrosis after hepatic IR. However, exposure to a HFD for 2 weeks before surgery had no significant impact on kidney or hepatic function after IR or IH after focal carotid stenosis.
   Conclusions: Short-term dietary restriction immediately before surgery significantly attenuated the vascular wall hyperplastic response and improved IR outcome. The findings suggest plasticity in the body's response to these vascular surgical injuries that can be manipulated by novel yet practical preoperative dietary interventions.
   Clinical Relevance: In view of the high clinical complication rates in the setting of cardiovascular reconstructions (and their pathophysiologic links to ischemia-reperfusion and intimal hyperplasia), short-term dietary restriction stands as a particularly attractive, pleiotropic strategy for this population to enhance patient outcomes. Whereas employment of rodent models will be useful in refining our understanding of the nutritional basis of protection and underlying molecular mechanisms, inevitably multicenter randomized clinical trials will be required to determine efficacy of such approaches in humans.
C1 [Mauro, Christine R.; Tao, Ming; Yu, Peng; Longchamp, Alban; Ozaki, C. Keith] Harvard Univ, Sch Med, Brigham & Womens Hosp, Dept Surg, Cambridge, MA 02138 USA.
   [Kristal, Bruce S.] Harvard Univ, Sch Med, Brigham & Womens Hosp, Dept Neurosurg, Cambridge, MA 02138 USA.
   [Trevino-Villerreal, J. Humberto; Mitchell, James R.] Harvard Univ, Sch Publ Hlth, Dept Genet & Complex Dis, Cambridge, MA 02138 USA.
C3 Harvard University; Harvard University Medical Affiliates; Brigham &
   Women's Hospital; Harvard University; Harvard University Medical
   Affiliates; Brigham & Women's Hospital; Harvard University; Harvard T.H.
   Chan School of Public Health
RP Mitchell, JR (corresponding author), 655 Huntington Ave 2-121, Boston, MA 02115 USA.
EM jmitchel@hsph.harvard.edu
RI Ozaki, C/A-4937-2013
FU NHLBI NIH HHS [T32 HL007734, 1F32HL117521, T32HL007734, R01 HL133500,
   F32 HL117521] Funding Source: Medline; NIA NIH HHS [R56 AG036712, R01
   AG036712, R01 AG025872, AG036712, R01-AG25872] Funding Source: Medline;
   NIDDK NIH HHS [R01 DK090629, DK090629] Funding Source: Medline
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NR 37
TC 33
Z9 37
U1 0
U2 8
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0741-5214
J9 J VASC SURG
JI J. Vasc. Surg.
PD FEB
PY 2016
VL 63
IS 2
BP 500
EP +
DI 10.1016/j.jvs.2014.07.004
PG 11
WC Surgery; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery; Cardiovascular System & Cardiology
GA DE6XV
UT WOS:000370779100034
PM 25124359
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU González-Hedström, D
   Amor, S
   de la Fuente-Fernández, M
   Tejera-Muñoz, A
   Priego, T
   Martín, AI
   López-Calderón, A
   Inarejos-García, AM
   García-Villalón, AL
   Granado, M
AF Gonzalez-Hedstrom, Daniel
   Amor, Sara
   de la Fuente-Fernandez, Maria
   Tejera-Munoz, Antonio
   Priego, Teresa
   Isabel Martin, Ana
   Lopez-Calderon, Asuncion
   Manuel Inarejos-Garcia, Antonio
   Luis Garcia-Villalon, Angel
   Granado, Miriam
TI A Mixture of Algae and Extra Virgin Olive Oils Attenuates the
   Cardiometabolic Alterations Associated with Aging in Male Wistar Rats
SO ANTIOXIDANTS
LA English
DT Article
DE aging; omega 3 fatty acids; extra virgin olive oil; insulin resistance;
   cardiovascular; inflammation; oxidative stress; endothelial dysfunction
ID AGE-RELATED INFLAMMATION; FATTY-ACID-COMPOSITION; NITRIC-OXIDE SYNTHASE;
   ENDOTHELIAL FUNCTION; INSULIN-RESISTANCE; DOCOSAHEXAENOIC ACID;
   METABOLIC SYNDROME; OMEGA-3-FATTY-ACIDS; SUPPLEMENTATION; OMEGA-3
AB Aging is one of the major risk factors for suffering cardiovascular and metabolic diseases. Due to the increase in life expectancy, there is a strong interest in the search for anti-aging strategies to treat and prevent these aging-induced disorders. Both omega 3 polyunsaturated fatty acids (omega-3 PUFA) and extra virgin olive oil (EVOO) exert numerous metabolic and cardiovascular benefits in the elderly. In addition, EVOO constitutes an interesting ingredient to stabilize omega-3 PUFA and decrease their oxidation process due to its high content in antioxidant compounds. omega-3 PUFA are commonly obtained from fish. However, more ecological and sustainable sources, such as algae oil (AO) can also be used. In this study, we aimed to study the possible beneficial effect of an oil mixture composed by EVOO (75%) and AO (25%) rich in omega-3 PUFA (35% docosahexaenoic acid (DHA) and 20% eicosapentaenoic acid (EPA)) on the cardiometabolic alterations associated with aging. For this purpose; young (three months old) and old (24 months old) male Wistar rats were treated with vehicle or with the oil mixture (2.5 mL/kg) for 21 days. Treatment with the oil mixture prevented the aging-induced increase in the serum levels of saturated fatty acids (SFA) and the aging-induced decrease in the serum concentrations of mono-unsaturated fatty acids (MUFA). Old treated rats showed increased serum concentrations of EPA and DHA and decreased HOMA-IR index and circulating levels of total cholesterol, insulin and IL-6. Treatment with the oil mixture increased the mRNA levels of antioxidant and insulin sensitivity-related enzymes, as well as reduced the gene expression of pro-inflammatory markers in the liver and in cardiac and aortic tissues. In addition, the treatment also prevented the aging-induced endothelial dysfunction and vascular insulin resistance through activation of the PI3K/Akt pathway. Moreover, aortic rings from old rats treated with the oil mixture showed a decreased response to the vasoconstrictor AngII. In conclusion, treatment with a mixture of EVOO and AO improves the lipid profile, insulin sensitivity and vascular function in aged rats and decreases aging-induced inflammation and oxidative stress in the liver, and in the cardiovascular system. Thus, it could be an interesting strategy to deal with cardiometabolic alterations associated with aging.
C1 [Gonzalez-Hedstrom, Daniel; Amor, Sara; de la Fuente-Fernandez, Maria; Tejera-Munoz, Antonio; Luis Garcia-Villalon, Angel; Granado, Miriam] Univ Autonoma Madrid, Fac Med, Dept Fisiol, Madrid 28029, Spain.
   [Gonzalez-Hedstrom, Daniel; Manuel Inarejos-Garcia, Antonio] Pharmact Biotech Prod SL, Parque Cientif Madrid,Ave Doctor Severo Ochoa, Madrid 28108, Spain.
   [Priego, Teresa; Isabel Martin, Ana; Lopez-Calderon, Asuncion] Univ Complutense Madrid, Fac Med, Dept Fisiol, Madrid 28040, Spain.
   [Granado, Miriam] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr, Madrid 28029, Spain.
C3 Autonomous University of Madrid; Complutense University of Madrid; CIBER
   - Centro de Investigacion Biomedica en Red; CIBEROBN; Instituto de Salud
   Carlos III
RP Granado, M (corresponding author), Univ Autonoma Madrid, Fac Med, Dept Fisiol, Madrid 28029, Spain.; Granado, M (corresponding author), Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr, Madrid 28029, Spain.
EM dgonzalez@pharmactive.eu; sara.amor@uam.es; maria.delafuente@uam.es;
   antonio.tejera@quironsalud.es; tpriegoc@med.ucm.es;
   anabelmartin@med.ucm.es; alc@med.ucm.es; aminarejos@hotmail.com;
   angeluis.villalon@uam.es; miriam.granado@uam.es
RI Martin, Ana Isabel/K-5301-2014; Granado, Miriam/B-8978-2017; Tejera
   Munoz, Antonio/R-8513-2017; Priego, Teresa/MBI-0297-2025;
   Lopez-Calderon, Asuncion/H-2442-2017
OI Martin, Ana Isabel/0000-0002-4445-590X; Granado,
   Miriam/0000-0001-9178-8822; Tejera Munoz, Antonio/0000-0002-7954-5753;
   Priego, Teresa/0000-0001-5397-0877; Gonzalez-Hedstrom,
   Daniel/0000-0001-9425-1115; Lopez-Calderon, Asuncion/0000-0003-0716-6276
FU Community of Madrid (Spain) [IND2017/BIO7701]; Community of Madrid
   [PEJ-2018-AI/SAL-11315]
FX This project was funded by the call "Doctorados Industriales 2017"
   (IND2017/BIO7701), a grant from Community of Madrid (Spain). This
   program aims to promote the effective collaboration between Universities
   and Companies and provides funding for the development of the research
   project at the University and, to hire a PhD student (Daniel
   Gonzalez-Hedstrom) by the Company (Pharmactive Biotech Products S.L.)
   over a three-year period. Community of Madrid also funded the contract
   of Maria de la Fuente-Fernandez through the Youth Employment Program
   (PEJ-2018-AI/SAL-11315).
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NR 88
TC 12
Z9 12
U1 4
U2 18
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD JUN
PY 2020
VL 9
IS 6
AR 483
DI 10.3390/antiox9060483
PG 20
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA MO0MR
UT WOS:000551231900001
PM 32503213
OA Green Published, Green Accepted, gold
DA 2025-06-11
ER

PT J
AU Kuo, KL
   Hung, SC
   Lin, YP
   Tang, CF
   Lee, TS
   Lin, CP
   Tarng, DC
AF Kuo, Ko-Lin
   Hung, Szu-Chun
   Lin, Yao-Ping
   Tang, Ching-Fang
   Lee, Tzong-Shyuan
   Lin, Chih-Pei
   Tarng, Der-Cherng
TI Intravenous Ferric Chloride Hexahydrate Supplementation Induced
   Endothelial Dysfunction and Increased Cardiovascular Risk among
   Hemodialysis Patients
SO PLOS ONE
LA English
DT Article
ID TRANSCRIPTION FACTOR ACTIVATION; ADHESION MOLECULE EXPRESSION; OXYGEN
   SPECIES GENERATION; MEDIATED FENTON REACTIONS; CARDIAC SYNDROME-X; BODY
   IRON STORES; NF-KAPPA B; MYOCARDIAL-INFARCTION; PARENTERAL IRON; NADPH
   OXIDASE
AB Background: The association between intravenous (IV) iron administration and outcomes in hemodialysis (HD) patients is still debated. Therefore, this study was aimed to assess the relationship between the IV administration of ferric chloride hexahydrate (Atofen (R)) and cardiovascular (CV) outcome and the interaction between iron-induced oxidative stress and endothelial dysfunction in chronic HD patients.
   Methodology/Principal Findings: A cohort of 1239 chronic HD patients was recruited. In a follow-up of 12 months, Kaplan-Meier survival curves showed that higher doses of IV Atofen associated with higher risks for CV events and deaths in HD patients. In multivariate Cox models, compared to no iron supplementation, IV Atofen administration was an independent predictor for CV events and overall mortality. However, the nature of the observational cohort study possibly bears selection bias. We further found that IV Atofen enhanced the superoxide production of mononuclear cells (MNCs), the levels of circulating soluble adhesion molecules, and the adhesion of MNCs to human aortic endothelial cells (HAECs). In vitro experiments showed that Atofen increased the expression of intracellular cell adhesion molecule-1 and vascular cell adhesion molecule-1 in HAECs and aggravated the endothelial adhesiveness in a dose-dependent manner. These iron-induced changes were significantly attenuated by the co-treatment of HAECs with N-acetylcysteine and inhibitors of NADPH oxidase, nuclear factor kappa B, and activator protein-1.
   Conclusion: A cumulative dose of IV Atofen > 800 mg within 6 months was associated with an adverse CV outcome and a higher mortality among chronic HD patients. The detrimental effects of IV iron supplementation were partly due to the increased oxidative stress and induction of MNC adhesion to endothelial cells, a pivotal index of early atherogenesis. Citation: Kuo K-L, Hung S-C, Lin Y-P, Tang C-F, Lee T-S, et al. (2012) Intravenous Ferric Chloride Hexahydrate Supplementation Induced Endothelial Dysfunction and Increased Cardiovascular Risk among Hemodialysis Patients. PLoS ONE 7(12): e50295. doi:10.1371/journal.pone.0050295
C1 [Kuo, Ko-Lin; Lee, Tzong-Shyuan; Tarng, Der-Cherng] Natl Yang Ming Univ, Dept & Inst Physiol, Taipei 112, Taiwan.
   [Tarng, Der-Cherng] Natl Yang Ming Univ, Inst Clin Med, Taipei 112, Taiwan.
   [Lin, Chih-Pei] Natl Yang Ming Univ, Dept Biotechnol & Lab Sci Med, Taipei 112, Taiwan.
   [Lin, Chih-Pei] Natl Yang Ming Univ, Inst Biotechnol Med, Taipei 112, Taiwan.
   [Kuo, Ko-Lin; Hung, Szu-Chun] Tzu Chi Univ, Sch Med, Hualien, Taiwan.
   [Kuo, Ko-Lin; Hung, Szu-Chun] Buddhist Tzu Chi Gen Hosp, Taipei Branch, Div Nephrol, Taipei, Taiwan.
   [Lin, Chih-Pei] Taipei Vet Gen Hosp, Dept Pathol & Lab Med, Div Gen Lab, Taipei, Taiwan.
   [Lin, Yao-Ping; Tang, Ching-Fang; Tarng, Der-Cherng] Taipei Vet Gen Hosp, Dept Med, Div Nephrol, Taipei, Taiwan.
   [Lin, Yao-Ping; Tang, Ching-Fang; Tarng, Der-Cherng] Taipei Vet Gen Hosp, Ctr Immunol, Taipei, Taiwan.
C3 National Yang Ming Chiao Tung University; National Yang Ming Chiao Tung
   University; National Yang Ming Chiao Tung University; National Yang Ming
   Chiao Tung University; Tzu Chi University; Buddhist Tzu Chi General
   Hospital; Taipei Veterans General Hospital; Taipei Veterans General
   Hospital; Taipei Veterans General Hospital
RP Lin, CP (corresponding author), Natl Yang Ming Univ, Dept Biotechnol & Lab Sci Med, Taipei 112, Taiwan.
EM cplin@vghtpe.gov.tw; dctarng@vghtpe.gov.tw
RI Lee, Tzong-Shyuan/AAE-5803-2020; Kuo, Ko-Lin/AGW-7451-2022
OI Kuo, Ko-Lin/0000-0002-7477-0388; LEE, TZONG-SHYUAN/0000-0002-9593-4062
FU National Science Council [NSC 96-2628-B-010-001-MY3, NSC
   99-2314-B-303-002-MY3]; Taipei Veterans General Hospital [V100C-143,
   V100E4-003]; Ministry of Education's Aim for the Top University Plan;
   Taipei Tzu Chi General Hospital [TCRD-TPE-97-15]
FX This work was supported by grants from the National Science Council (NSC
   96-2628-B-010-001-MY3 and NSC 99-2314-B-303-002-MY3), Taipei Veterans
   General Hospital (V100C-143 and V100E4-003), Ministry of Education's Aim
   for the Top University Plan, and Taipei Tzu Chi General Hospital
   (TCRD-TPE-97-15). The funders had no role in study design, data
   collection and analysis, decision to publish, or preparation of the
   manuscript.
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NR 45
TC 64
Z9 65
U1 0
U2 5
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD DEC 5
PY 2012
VL 7
IS 12
AR e50295
DI 10.1371/journal.pone.0050295
PG 12
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 057TZ
UT WOS:000312588200026
PM 23227165
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Ricanati, EHW
   Golubic, M
   Yang, DS
   Saager, L
   Mascha, EJ
   Roizen, MF
AF Ricanati, Elizabeth H. W.
   Golubic, Mladen
   Yang, Dongsheng
   Saager, Leif
   Mascha, Edward J.
   Roizen, Michael F.
TI Mitigating preventable chronic disease: Progress report of the Cleveland
   Clinic's Lifestyle 180 program
SO NUTRITION & METABOLISM
LA English
DT Article
DE Lifestyle; Nutrition; Exercise; Stress Management; Chronic disease;
   Obesity; Hyperlipidemia; Hypertension; Diabetes
ID MEDITERRANEAN DIET; METABOLIC SYNDROME; INTERVENTION; OBESITY;
   TRIGLYCERIDES; CHOLESTEROL; REDUCTION; SPAN
AB Background: Poor lifestyle choices are key in development and progression of preventable chronic diseases. The purpose of the study was to design and test a program to mitigate the physical and fiscal consequences of chronic diseases.
   Methods: Here we report the outcomes for 429 participants with one or more chronic conditions, including obesity, hypertension, hyperlipidemia and diabetes mellitus, many of whom had failed traditional disease management programs, who enrolled into a comprehensive lifestyle intervention. The Lifestyle 180 program integrates nutrition, physical activity and stress management interventions and was conducted at the Wellness Institute of the Cleveland Clinic, United States. An intensive 6 week immersion course, with 8 hours of group instruction per week, was followed by 3 follow-up, 4 hour-long sessions over the course of 6 months.
   Results: Changes in biometric (weight, height, waist circumference, resting heart rate and blood pressure) and laboratory variables (fasting lipid panel, blood glucose, insulin, hemoglobin A1c, ultra sensitive C-reactive protein) at 6 months were compared with baseline (pre-post analysis). At week 30, biometric and laboratory data were available for 244 (57%) and 299 (70%) participants, respectively. These had a mean +/- SD reduction in weight (6.8 +/- 6.9 kg, P < 0.001), waist circumference (6.1 +/- 7.3 cm, P < 0.001), glucose (4.5 +/- 29.6 mg/dL or 0.25 +/- 1.64 mmol/L, P = 0.009), triglycerides (26.4 +/- 58.5 mg/dL or 0.30 +/- 0.66 mmol/L, P < 0.001), low-density lipoprotein cholesterol (LDL) (7.9 +/- 25.1 mg/dL or 0.2 +/- 0.65 mmol/L, P < 0.001), hemoglobin A1c (HgbA1c) (0.20 +/- 0.64%, P = 0.001), insulin (3.8 +/- 11 microU/ml or 26.6 +/- 76.4 rho mol, P < 0.001) and ultra sensitive C-reactive protein (US - CRP) (0.9 +/- 4.8 mg/dL or 7.3 +/- 40.2 nmol/L, P = 0.012), an increase in mean high-density lipoprotein cholesterol (HDL) (3.7 +/- 8.4 mg/dL or 0.1 +/- 0.22, P < 0.001), and decreased use of medications.
   Conclusion: Implementation of a comprehensive lifestyle modification program among adults with common chronic conditions results in significant and clinically meaningful improvements in biometric and laboratory outcomes after 6 months.
C1 [Ricanati, Elizabeth H. W.; Golubic, Mladen; Roizen, Michael F.] Cleveland Clin, Wellness Inst, Lyndhurst, OH 44124 USA.
   [Yang, Dongsheng; Saager, Leif; Mascha, Edward J.] Cleveland Clin, Cleveland, OH 44195 USA.
C3 Cleveland Clinic Foundation; Cleveland Clinic Foundation
RP Golubic, M (corresponding author), Cleveland Clin, Wellness Inst, 1950 Richmond Rd,TR2-341, Lyndhurst, OH 44124 USA.
EM golubim@ccf.org
RI Kattan, Michael/HZM-2315-2023; yang, dongsheng/GSD-9263-2022; Saager,
   Leif/M-4623-2013
OI Saager, Leif/0000-0003-3416-4727
FU Wellness Institute of the Cleveland Clinic
FX We are grateful to all participants in the Lifestyle 180 program and the
   companies that sponsored their participation. We also thank the two
   anonymous reviewers for their insightful comments and suggestions that
   helped improve this communication. This study was supported by the
   Wellness Institute of the Cleveland Clinic.
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NR 43
TC 23
Z9 23
U1 0
U2 7
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1743-7075
J9 NUTR METAB
JI Nutr. Metab.
PD NOV 23
PY 2011
VL 8
AR 83
DI 10.1186/1743-7075-8-83
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 893PA
UT WOS:000300366600001
PM 22112436
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Nemeth, Z
   Patonai, A
   Simon-Szabó, L
   Takács, I
AF Nemeth, Zsuzsanna
   Patonai, Attila
   Simon-Szabo, Laura
   Takacs, Istvan
TI Interplay of Vitamin D and SIRT1 in Tissue-Specific Metabolism-Potential
   Roles in Prevention and Treatment of Non-Communicable Diseases Including
   Cancer
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE vitamin D; SIRT1; metabolism; epigenetics; signaling pathways;
   prevention and treatment
ID RESVERATROL-INDUCED APOPTOSIS; INHIBITS OXIDATIVE STRESS;
   SMOOTH-MUSCLE-CELLS; 1-ALPHA,25-DIHYDROXYVITAMIN D-3;
   1,25-DIHYDROXYVITAMIN D-3; D DEFICIENCY; DIABETES-MELLITUS; D-RECEPTOR;
   VASCULAR CALCIFICATION; ENDOTHELIAL-CELLS
AB The importance of the prevention and control of non-communicable diseases, including obesity, metabolic syndrome, type 2 diabetes, cardiovascular diseases, and cancer, is increasing as a requirement of the aging population in developed countries and the sustainability of healthcare. Similarly, the 2013-2030 action plan of the WHO for the prevention and control of non-communicable diseases seeks these achievements. Adequate lifestyle changes, alone or with the necessary treatments, could reduce the risk of mortality or the deterioration of quality of life. In our recent work, we summarized the role of two central factors, i.e., appropriate levels of vitamin D and SIRT1, which are connected to adequate lifestyles with beneficial effects on the prevention and control of non-communicable diseases. Both of these factors have received increased attention in relation to the COVID-19 pandemic as they both take part in regulation of the main metabolic processes, i.e., lipid/glucose/energy homeostasis, oxidative stress, redox balance, and cell fate, as well as in the healthy regulation of the immune system. Vitamin D and SIRT1 have direct and indirect influence of the regulation of transcription and epigenetic changes and are related to cytoplasmic signaling pathways such as PLC/DAG/IP3/PKC/MAPK, MEK/Erk, insulin/mTOR/cell growth, proliferation; leptin/PI3K-Akt-mTORC1, Akt/NF kappa B/COX-2, NF kappa B/TNF alpha, IL-6, IL-8, IL-1 beta, and AMPK/PGC-1 alpha/GLUT4, among others. Through their proper regulation, they maintain normal body weight, lipid profile, insulin secretion and sensitivity, balance between the pro- and anti-inflammatory processes under normal conditions and infections, maintain endothelial health; balance cell differentiation, proliferation, and fate; and balance the circadian rhythm of the cellular metabolism. The role of these two molecules is interconnected in the molecular network, and they regulate each other in several layers of the homeostasis of energy and the cellular metabolism. Both have a central role in the maintenance of healthy and balanced immune regulation and redox reactions; therefore, they could constitute promising targets either for prevention or as complementary therapies to achieve a better quality of life, at any age, for healthy people and patients under chronic conditions.
C1 [Nemeth, Zsuzsanna; Takacs, Istvan] Semmelweis Univ, Dept Internal Med & Oncol, Korany S U 2-A, H-1083 Budapest, Hungary.
   [Patonai, Attila] Semmelweis Univ, Dept Surg Transplantat & Gastroenterol, Ullo U 78, H-1082 Budapest, Hungary.
   [Simon-Szabo, Laura] Semmelweis Univ, Dept Mol Biol, Tuzolto U 37-47, H-1094 Budapest, Hungary.
C3 Semmelweis University; Semmelweis University; Semmelweis University
RP Nemeth, Z (corresponding author), Semmelweis Univ, Dept Internal Med & Oncol, Korany S U 2-A, H-1083 Budapest, Hungary.
EM nemeth.zsuzsanna@med.semmelweis-univ.hu
RI Takács, István/O-3018-2017
OI , Laura/0009-0007-5336-2979
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NR 233
TC 14
Z9 14
U1 3
U2 8
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD APR
PY 2023
VL 24
IS 7
AR 6154
DI 10.3390/ijms24076154
PG 25
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA D7DP8
UT WOS:000970298700001
PM 37047134
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU de Lima, RMS
   Barth, B
   Arcego, DM
   de Mendonca, EJ
   Patel, S
   Wang, ZH
   Pokhvisneva, I
   Parent, C
   Levitan, RD
   Kobor, MS
   Bittencourt, APSD
   Meaney, MJ
   Dalmaz, C
   Silveira, PP
AF Sobreira de Lima, Randriely Merscher
   Barth, Barbara
   Arcego, Danusa Mar
   de Mendonca Filho, Euclides Jose
   Patel, Sachin
   Wang, Zihan
   Pokhvisneva, Irina
   Parent, Carine
   Levitan, Robert D.
   Kobor, Michael S.
   Santana de Vasconcellos Bittencourt, Ana Paula
   Meaney, Michael J.
   Dalmaz, Carla
   Silveira, Patricia Pelufo
TI Leptin receptor co-expression gene network moderates the effect of early
   life adversity on eating behavior in children
SO COMMUNICATIONS BIOLOGY
LA English
DT Article
ID FOOD-INTAKE; ENERGY HOMEOSTASIS; BODY-WEIGHT; STRESS; BRAIN; POPULATION;
   MECHANISMS; ADIPOSITY; PATHWAYS; CIRCUITS
AB An expression-based polygenic risk score analysis of leptin receptor (LepR) genes suggests that LepR-specific genes co-expressed in the prefrontal cortex interact with exposure to postnatal adversity, potentially modulating eating behavior in children.
   Leptin influences eating behavior. Exposure to early adversity is associated with eating behaviour disorders and metabolic syndrome, but the role of the leptin receptor on this relationship is poorly explored. We investigated whether individual differences in brain region specific leptin receptor (LepR) gene networks could moderate the effects of early adversity on eating behavior and metabolism. We created an expression-based polygenic risk score (ePRS) reflecting variations in the function of LepR gene network in prefrontal cortex and hypothalamus to investigate the interactions between a cumulative index of postnatal adversity on eating behavior in two independent birth cohorts (MAVAN and GUSTO). To explore whether variations in the prefrontal cortex or hypothalamic genetic scores could be associated with metabolic measurements, we also assessed the relationship between LepR-ePRS and fasting blood glucose and leptin levels in a third independent cohort (ALSPAC). We identified significant interaction effects between postnatal adversity and prefrontal-based LepR-ePRS on the Child Eating Behavior Questionnaire scores. In MAVAN, we observed a significant interaction effect on food enjoyment at 48 months (beta = 61.58, p = 0.015) and 72 months (beta = 97.78, p = 0.001); food responsiveness at 48 months (beta = 83.79, p = 0.009) satiety at 48 months (beta = -43.63, p = 0.047). Similar results were observed in the GUSTO cohort, with a significant interaction effect on food enjoyment (beta = 30.48, p = 0.006) food fussiness score (beta = -24.07, p = 0.02) and satiety score at 60 months (beta = -17.00, p = 0.037). No effects were found when focusing on the hypothalamus-based LepR-ePRS on eating behavior in MAVAN and GUSTO cohorts, and there was no effect of hypothalamus and prefrontal cortex based ePRSs on metabolic measures in ALSPAC. Our study indicated that exposure to postnatal adversity interacts with prefrontal cortex LepR-ePRS to moderate eating behavior, suggesting a neurobiological mechanism associated with the development of eating behavior problems in response to early adversity. The knowledge of these mechanisms may guide the understanding of eating patterns associated with risk for obesity in response to fluctuations in stress exposure early in life.
C1 [Sobreira de Lima, Randriely Merscher; Arcego, Danusa Mar; de Mendonca Filho, Euclides Jose; Meaney, Michael J.; Silveira, Patricia Pelufo] McGill Univ, Fac Med, Dept Psychiat, Montreal, PQ, Canada.
   [Sobreira de Lima, Randriely Merscher; Dalmaz, Carla] Univ Fed Rio Grande do Sul, Inst Ciencias Basicas Saude ICBS, Programa Posgrad Neurociencias, Porto Alegre, RS, Brazil.
   [Barth, Barbara] McGill Univ, Integrated Program Neurosci IPN, Montreal, PQ, Canada.
   [de Mendonca Filho, Euclides Jose] Univ Fed Rio Grande do Sul, Inst Psicol, Programa Posgrad Psicol, Porto Alegre, RS, Brazil.
   [Patel, Sachin; Wang, Zihan; Pokhvisneva, Irina; Parent, Carine; Silveira, Patricia Pelufo] McGill Univ, Ludmer Ctr Neuroinformat & Mental Hlth, Douglas Res Ctr, Montreal, PQ, Canada.
   [Levitan, Robert D.] Univ Toronto, Dept Psychiat, 250 Coll St, Toronto, ON, Canada.
   [Levitan, Robert D.] Ctr Addict & Mental Hlth, 250 Coll St, Toronto, ON, Canada.
   [Kobor, Michael S.] Univ British Columbia, BC Childrens Hosp Res Inst, Ctr Mol Med & Therapeut, Dept Med Genet, 938 West 28th Ave, Vancouver, BC, Canada.
   [Santana de Vasconcellos Bittencourt, Ana Paula] Univ Fed Espirito Santo, Dept Ciencias Fisiol, Vitoria, ES, Brazil.
   [Meaney, Michael J.] ASTAR, Singapore Inst Clin Sci, Singapore, Singapore.
   [Dalmaz, Carla] Univ Fed Rio Grande do Sul, Inst Ciencias Basicas Saude, Dept Bioquim, Programa Posgrad Ciencias Biol Bioquim, Porto Alegre, RS, Brazil.
C3 McGill University; Universidade Federal do Rio Grande do Sul; McGill
   University; Universidade Federal do Rio Grande do Sul; McGill
   University; University of Toronto; University of Toronto; Centre for
   Addiction & Mental Health - Canada; University of British Columbia; BC
   Children's Hospital; BC Children's Hospital Research Institute;
   Universidade Federal do Espirito Santo; Agency for Science Technology &
   Research (A*STAR); A*STAR - Singapore Institute for Clinical Sciences
   (SICS); Universidade Federal do Rio Grande do Sul
RP Silveira, PP (corresponding author), McGill Univ, Fac Med, Dept Psychiat, Montreal, PQ, Canada.; Silveira, PP (corresponding author), McGill Univ, Ludmer Ctr Neuroinformat & Mental Hlth, Douglas Res Ctr, Montreal, PQ, Canada.
EM patricia.silveira@mcgill.ca
RI de Mendonça Filho, Euclides José/MVX-8769-2025; Meaney,
   Michael/N-5931-2019; barth, barbara/IXW-6642-2023; dalmaz,
   carla/M-2069-2014; Silveira, Patricia/A-7139-2011; Silveira,
   Patricia/F-4897-2014
OI Patel, Sachin/0000-0002-4532-6659; Silveira,
   Patricia/0000-0001-8626-2519; Kobor, Michael/0000-0003-4140-1743;
   Dalmaz, Carla/0000-0001-5397-2792; Merscher Sobreira de lima,
   Randriely/0000-0002-4127-1996; Parent, Carine/0000-0002-3941-3764
FU Canadian Institutes of Health Research (CIHR) [PJT-166066]; JPB
   Foundation; Coordination of Improvement of Higher Level Personnel
   (CAPES); Cameron Holcombe Wilson Chair in Depression studies , CAMH;
   University of Toronto; Wellcome [217065/19Z//Z]
FX We are extremely grateful to all the families who took part in this
   study, the midwives and obstetricians, for their help in recruiting
   them, and the whole MAVAN, GUSTO, and ALSPAC teams, which includes
   interviewers, computer and laboratory technicians, clerical workers,
   research scientists, volunteers, managers, receptionists and nurses.
   This research was supported by Canadian Institutes of Health Research
   (CIHR, PJT-166066, PI Silveira PP), the JPB Foundation through a grant
   to the JPB Research Network on Toxic Stress: A Project of the Center on
   the Developing Child at Harvard University, and Coordination of
   Improvement of Higher Level Personnel (CAPES). Dr. Levitan acknowledges
   support from the Cameron Holcombe Wilson Chair in Depression studies,
   CAMH and University of Toronto. The UK Medical Research Council and
   Wellcome (Grant ref: 217065/19Z//Z) and the University of Bristol
   provide core support for ALSPAC. This publication is the work of the
   authors and Patricia Pelufo Silveira will serve as guarantor for the
   contents of this paper.
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NR 77
TC 7
Z9 7
U1 2
U2 7
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
EI 2399-3642
J9 COMMUN BIOL
JI Commun. Biol.
PD OCT 14
PY 2022
VL 5
IS 1
AR 1092
DI 10.1038/s42003-022-03992-8
PG 10
WC Biology; Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics; Science & Technology - Other
   Topics
GA 5I4TX
UT WOS:000868352200004
PM 36241774
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU van der Voorn, B
   Hollanders, JJ
   Ket, JCF
   Rotteveel, J
   Finken, MJJ
AF van der Voorn, Bibian
   Hollanders, Jonneke J.
   Ket, Johannes C. F.
   Rotteveel, Joost
   Finken, Martijn J. J.
TI Gender-specific differences in hypothalamus-pituitary-adrenal axis
   activity during childhood: a systematic review and meta-analysis
SO BIOLOGY OF SEX DIFFERENCES
LA English
DT Review
DE Glucocorticoid; Stress hormone; Infant; Pediatric; Sex characteristics
ID PEDIATRIC REFERENCE INTERVALS; SEXUAL-DIMORPHISM; CORTISOL-LEVELS;
   METABOLIC SYNDROME; SALIVARY CORTISOL; HPA AXIS; CHILDREN; STRESS; AGE;
   ADOLESCENCE
AB Background: Gender-specific differences in hypothalamus-pituitary-adrenal (HPA) axis activity have been postulated to emerge during puberty. We conducted a systematic review and meta-analysis to test the hypothesis that gender-specific differences in HPA axis activity are already present in childhood.
   Methods: From inception to January 2016, PubMed and EMBASE.com were searched for studies that assessed non-stimulated cortisol in serum or saliva or cortisol in 24-h urine in healthy males and females aged <= 18 years. Studies that conform with the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) statement were reported. Standardized mean differences (95% CIs) were calculated and analyzed using fixed-effect meta-analysis stratified for age: < 8 years (prepubertal) and 8-18 years (peri-/postpubertal). For comparison, we ran the same analyses using random-effects models.
   Results: Two independent assessors selected 413 out of 6158 records (7%) for full-text screening, of which 79 articles were included. Of these, 58 (with data on 16,551 subjects) were included in the meta-analysis. Gender differences in cortisol metabolism differed per age group. Boys aged < 8 years had 0.18 (0.06; 0.30) nmol/L higher serum and 0.21 (0.05; 0.37) nmol/L higher salivary cortisol levels, while between 8 and 18 years, boys had 0.34 (0.28; 0.40) nmol/L lower serum and 0.42 (0.38; 0.47) nmol/L lower salivary cortisol levels. In 24-h urine, cortisol was consistently higher in boys, being 0.34 (0.05; 0.64) and 0.32 (0.17; 0.47) mu g/24 h higher in the < 8- and 8-18-year groups, respectively. However, gender-differences in serum cortisol < 8 years and between 8 and 18 years were absent when using random-effects models.
   Conclusions: Gender differences in cortisol metabolism are already present in childhood, with higher salivary cortisol in boys aged < 8 years compared to girls. This pattern was reversed after the age of 8 years. In contrast, the gender-specific difference in cortisol production as assessed through 24-h urine did not change with age. Although differences were small, and analyses of gender differences in serum cortisol were inconclusive, they might contribute to gender-specific origins of health and disease.
C1 [van der Voorn, Bibian; Hollanders, Jonneke J.; Rotteveel, Joost; Finken, Martijn J. J.] Vrije Univ Amsterdam, Med Ctr, Dept Pediat Endocrinol, Postbus 7057, NL-1007 MB Amsterdam, Netherlands.
   [Ket, Johannes C. F.] Vrije Univ, Med Lib, Boelelaan 1103, NL-1081 HV Amsterdam, Netherlands.
C3 Vrije Universiteit Amsterdam; Vrije Universiteit Amsterdam
RP van der Voorn, B (corresponding author), Vrije Univ Amsterdam, Med Ctr, Dept Pediat Endocrinol, Postbus 7057, NL-1007 MB Amsterdam, Netherlands.
EM b.vandervoorn@vumc.nl
RI Ket, Johannes/F-4415-2011; van der Voorn, Bibian/ABB-3751-2021; Ket,
   Johannes C.F./B-7966-2017
OI van der Voorn, Bibian/0000-0003-1299-0067; Ket, Johannes
   C.F./0000-0002-1909-3150
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NR 52
TC 52
Z9 55
U1 0
U2 15
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 2042-6410
J9 BIOL SEX DIFFER
JI Biol. Sex Differ.
PD JAN 19
PY 2017
VL 8
AR 3
DI 10.1186/s13293-016-0123-5
PG 9
WC Endocrinology & Metabolism; Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Genetics & Heredity
GA EI8NI
UT WOS:000392762700001
PM 28116043
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Zhou, SF
   Xu, HS
   Zhu, JY
   Fan, XS
   Zhang, JM
AF Zhou, Sifeng
   Xu, Haishu
   Zhu, Jieyun
   Fan, Xinsheng
   Zhang, Jinming
TI Clinical efficacy and metabolomics study of Wendan Decoction in the
   treatment of phlegm-dampness obstructive sleep apnea-hypopnea syndrome
   with type 2 diabetes mellitus
SO JOURNAL OF ETHNOPHARMACOLOGY
LA English
DT Article
DE Wendan Decoction; Phlegm-dampness; OSAHS; Type 2 diabetes mellitus;
   Metabolomics
ID L-ARGININE; PREVALENCE; ANTIOXIDANT; CORTISOL; RATS; NO
AB Ethnopharmacological relevance: Wendan Decoction (WDD) is one of the classic traditional Chinese prescriptions that has been used in the treatment of type 2 diabetes mellitus (T2DM), metabolic syndrome, obstructive sleep apnea-hypopnea syndrome (OSAHS) and so on. The therapeutic effects and mechanism of WDD remain to be explored, especially from the perspective of metabolomics, oxidative stress and inflammation. Aim of the study: To investigate the therapeutic and metabolic regulatory effects and the underlying mechanism of WDD in OSAHS with T2DM patients.Materials and methods: All included patients were from Rudong Hospital of Traditional Chinese Medicine, Nantong, Jiangsu Province, China. Both groups received lifestyle interventions; at the same time, all of them were administered metformin (1500 mg/day) and dapagliflozin (10 mg/day), and the treatment group was administered WDD orally. All patients were treated for two months. Before and after treatment, the changes in clinical symptoms and signs of the two groups of patients were evaluated, and the detection indicators such as body mass index (BMI), apnea-hypopnea index (AHI), lowest arterial oxygen saturation (LSaO2), Epworth sleepiness scale (ESS), percentage of total sleep time with oxygen saturation <90% (TST90), fasting plasma glucose (FPG), 2-h post-load glucose(2h-PG), fasting insulin (FINS), homeostasis model assessment of insulin resistance (HOMAIR),hemoglobin A1c (HbA1c), blood lipid levels, as well as the adverse reactions and compliance of the patients were observed and detection of serum metabolites in patients to screen out specific biomarkers. The serum metabolic profile of WDD in OSAHS with T2DM patients was explored using ultra-high-performance liquid chromatography-quadrupole/electrostatic field orbitrap high-resolution mass spectrometry (UPLC-Q Orbitrap HRMS).Results: After treatment with WDD for 8 weeks, biochemical indicators, including BMI, FPG, 2h-PG, blood lipid, FINS, HbA1c, AHI, ESS, LSaO2, TST90, and HOMA-IR, were significantly improved. Serum metabolomic analysis showed that metabolites were differentially expressed before and after WDD-treated patients. Metabolomics results revealed that WDD regulated the biomarkers, such as DL-arginine, guaiacol sulfate, azelaic acid, phloroglucinol, uracil, L-tyrosine, cascarillin, Cortisol and L-alpha-lysophosphatidylcholine. Pathway enrichment analysis showed that the metabolites were associated with oxidative stress and inflammation. Conclusion: The study based on clinical research and metabolomics indicated that WDD can improve OSAHS with T2DM through multiple targets and pathways, and it may be a useful alternative therapy for the treatment of OSAHS with T2DM patients.
C1 [Zhou, Sifeng; Zhang, Jinming] Rudong Hosp Tradit Chinese Med, Dept Endocrinol, Nantong 226400, Jiangsu, Peoples R China.
   [Zhou, Sifeng; Fan, Xinsheng] Nanjing Univ Chinese Med, Sch Tradit Chinese Med Integrated Chinese & Wester, Nanjing 210023, Jiangsu, Peoples R China.
   [Xu, Haishu] Rudong Hosp Tradit Chinese Med, Dept Pharm, Nantong 226400, Jiangsu, Peoples R China.
   [Zhu, Jieyun] Rudong Hosp Tradit Chinese Med, Dept Ophthalmol, Nantong 226400, Jiangsu, Peoples R China.
C3 Nanjing University of Chinese Medicine
RP Fan, XS (corresponding author), Nanjing Univ Chinese Med, Sch Tradit Chinese Med Integrated Chinese & Wester, Nanjing 210023, Jiangsu, Peoples R China.
EM zhousifeng1987@126.com; 570499816@qq.com; icehappy2020@163.com;
   fanxsh126@126.com; zjm.625403@163.com
RI Zhou, Sifeng/ISV-1035-2023
OI Zhou, Sifeng/0000-0002-9276-9858
FU Health Commission of Nantong, Jiangsu Province, China [QA2020054];
   Rudong Hospital of Traditional Chinese Medicine [DZ202104]
FX This study was supported by the Health Commission of Nantong, Jiangsu
   Province, China (no. QA2020054) and Rudong Hospital of Traditional
   Chinese Medicine (no. DZ202104) . Thanks to colleagues from
   Endocrinology Department of Rudong Hospital of Traditional Chinese
   Medicine for their help in the research process.
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NR 44
TC 5
Z9 5
U1 5
U2 26
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0378-8741
EI 1872-7573
J9 J ETHNOPHARMACOL
JI J. Ethnopharmacol.
PD DEC 5
PY 2023
VL 317
AR 116775
DI 10.1016/j.jep.2023.116775
EA JUN 2023
PG 11
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA M8XR3
UT WOS:001032994200001
PM 37311503
DA 2025-06-11
ER

PT J
AU Fowke, JH
   Koyama, T
   Fadare, O
   Clark, PE
AF Fowke, Jay H.
   Koyama, Tatsuki
   Fadare, Oluwole
   Clark, Peter E.
TI Does Inflammation Mediate the Obesity and BPH Relationship? An
   Epidemiologic Analysis of Body Composition and Inflammatory Markers in
   Blood, Urine, and Prostate Tissue, and the Relationship with Prostate
   Enlargement and Lower Urinary Tract Symptoms
SO PLOS ONE
LA English
DT Article
ID CANCER PREVENTION TRIAL; METABOLIC SYNDROME; OXIDATIVE STRESS;
   HYPERPLASIA; RISK; ASSOCIATION; MEN; PROGRESSION; EXPRESSION; INDEX
AB Background
   BPH is a common disease associated with age and obesity. However, the biological pathways between obesity and BPH are unknown. Our objective was to investigate biomarkers of systemic and prostate tissue inflammation as potential mediators of the obesity and BPH association.
   Methods
   Participants included 191 men without prostate cancer at prostate biopsy. Trained staff measured weight, height, waist and hip circumferences, and body composition by bioelectric impedance analysis. Systemic inflammation was estimated by serum IL-6, IL-1 beta, IL-8, and TNF-alpha; and by urinary prostaglandin E2 metabolite (PGE-M), F2-isoprostane (F2iP), and F2-isoprostane metabolite (F2iP-M) levels. Prostate tissue was scored for grade, aggressiveness, extent, and location of inflammatory regions, and also stained for CD3 and CD20 positive lymphocytes. Analyses investigated the association between multiple body composition scales, systemic inflammation, and prostate tissue inflammation against BPH outcomes, including prostate size at ultrasound and LUTS severity by the AUA-symptom index (AUA-SI).
   Results
   Prostate size was significantly associated with all obesity measures. For example, prostate volume was 5.5 to 9.0 mls larger comparing men in the 25th vs. 75th percentile of % body fat, fat mass (kg) or lean mass (kg). However, prostate size was not associated with proinflammatory cytokines, PGE-M, F2iP, F2iP-M, prostate tissue inflammation scores or immune cell infiltration. In contrast, the severity of prostate tissue inflammation was significantly associated with LUTS, such that there was a 7 point difference in AUA-SI between men with mild vs. severe inflammation (p = 0.004). Additionally, men with a greater waist-hip ratio (WHR) were significantly more likely to have severe prostate tissue inflammation (p = 0.02), and a high WHR was significantly associated with moderate/severe LUTS (OR = 2.56, p = 0.03) among those participants with prostate tissue inflammation.
   Conclusion
   The WHR, an estimate of centralized obesity, was associated with the severity of inflammatory regions in prostate tissue and with LUTS severity among men with inflammation. Our results suggest centralized obesity advances prostate tissue inflammation to increase LUTS severity. Clinically targeting centralized fat deposition may reduce LUTS severity. Mechanistically, the lack of a clear relationship between systemic inflammatory or oxidative stress markers in blood or urine with prostate size or LUTS suggests pathways other than systemic inflammatory signaling may link body adiposity to BPH outcomes.
C1 [Fowke, Jay H.] Vanderbilt Univ, Dept Med, Med Ctr, 221 Kirkland Hall, Nashville, TN 37235 USA.
   [Fowke, Jay H.; Clark, Peter E.] Vanderbilt Univ, Dept Urol Surg, Med Ctr, 221 Kirkland Hall, Nashville, TN 37235 USA.
   [Koyama, Tatsuki] Vanderbilt Univ, Dept Biostat, Med Ctr, 221 Kirkland Hall, Nashville, TN 37235 USA.
   [Fadare, Oluwole] Univ Calif San Diego, Dept Pathol, San Diego, CA 92103 USA.
C3 Vanderbilt University; Vanderbilt University; Vanderbilt University;
   University of California System; University of California San Diego
RP Fowke, JH (corresponding author), Vanderbilt Univ, Dept Med, Med Ctr, 221 Kirkland Hall, Nashville, TN 37235 USA.; Fowke, JH (corresponding author), Vanderbilt Univ, Dept Urol Surg, Med Ctr, 221 Kirkland Hall, Nashville, TN 37235 USA.
EM Jay.fowke@vanderbilt.edu
RI Koyama, Tatsuki/KLC-4137-2024
FU National Cancer Institute [RO1CA121060]; National Institute for Diabetes
   and Digestive Diseases [RO1DK087962, P20DK097782]
FX This study was supported by the National Cancer Institute,
   http://www.cancer.gov/, RO1CA121060 (JHF), and the National Institute
   for Diabetes and Digestive Diseases, www.niddk.nih.gov, RO1DK087962
   (JHF) and P20DK097782 (JHF, PEC). The funders had no role in study
   design, data collection and analysis, decision to publish, or
   preparation of the manuscript.
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NR 50
TC 40
Z9 44
U1 0
U2 3
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JUN 23
PY 2016
VL 11
IS 6
AR e0156918
DI 10.1371/journal.pone.0156918
PG 18
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA DP3JL
UT WOS:000378389200006
PM 27336586
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Datta, S
   Aggarwal, D
   Sehrawat, N
   Yadav, M
   Sharma, V
   Sharma, A
   Zghair, AN
   Dhama, K
   Sharma, A
   Kumar, V
   Sharma, AK
   Wang, HL
AF Datta, Sonal
   Aggarwal, Diwakar
   Sehrawat, Nirmala
   Yadav, Mukesh
   Sharma, Varruchi
   Sharma, Ajay
   Zghair, Abdulrazzaq N.
   Dhama, Kuldeep
   Sharma, Aanchal
   Kumar, Vikas
   Sharma, Anil K.
   Wang, Hailian
TI Hepatoprotective effects of natural drugs: Current trends, scope,
   relevance and future perspectives
SO PHYTOMEDICINE
LA English
DT Article
DE Liver toxicity; Phytochemicals; Drug-induced liver injury (DILI);
   Hepatoprotective agents; Probiotics; Prebiotics; Postbiotics, and
   synbiotics in hepatoprotection
ID FATTY LIVER-DISEASE; ANTIEPILEPTIC DRUGS; BREAST-CANCER; METABOLIC
   SYNDROME; INDUCED TOXICITY; HEPATOTOXICITY; INJURY; NARINGIN;
   DICLOFENAC; PROBIOTICS
AB Background: The liver is a well-known player in the metabolism and removal of drugs. Drug metabolizing enzymes in the liver detoxify drugs and xenobiotics, ultimately leading to the acquisition of homeostasis. However, liver toxicity and cell damage are not only related to the nature and dosage of a particular drug but are also influenced by other factors such as aging, immune status, environmental contaminants, microbial metabolites, gender, obesity, and expression of individual genes Furthermore, factors such as drugs, alcohol, and environ-mental contaminants could induce oxidative stress, thereby impairing the regenerative potential of the liver and causing several diseases. Persons suffering from other ailments and those with comorbidities are found to be more prone to drug-induced toxicities. Moreover, drug composition and drug-drug interactions could further aggravate the risk of drug-induced hepatotoxicity. A plethora of mechanisms are responsible for initiating liver cell damage and further aggravating liver cell injury, followed by impairment of homeostasis, ultimately leading to the generation of reactive oxygen species, immune-suppression, and oxidative stress.
   Objective: To summarize the potential of phytochemicals and natural bioactive compounds to treat hepatotoxicity and other liver diseases.
   Study design: A deductive qualitative content analysis approach was employed to assess the overall outcomes of the research and review articles pertaining to hepatoprotection induced by natural drugs, along with analysis of the interventions.
   Methods: An extensive literature search of bibliographic databases, including Web of Science, PUBMED, SCOPUS, GOOGLE SCHOLAR, etc., was carried out to understand the role of hepatoprotective effects of natural drugs.
   Results: Bioactive natural products, including curcumin, resveratrol, etc., have been seen as neutralizing agents against the side effects induced by the drugs. Moreover, these natural products are dietary and are readily available; thus, could be supplemented along with drugs to reduce toxicity to cells. Probiotics, prebiotics, and synbiotics have shown promise of improving overall liver functioning, and these should be evaluated more extensively for their hepatoprotective potential. Therefore, selecting an appropriate natural product or a bioactive compound that is free of toxicity and offers a reliable solution for drug-induced liver toxicity is quintessential.
   Conclusions: The current review highlights the role of natural bioactive products in neutralizing drug-induced hepatotoxicity. Efforts have been made to delineate the possible underlying mechanism associated with the neutralization process.
C1 [Datta, Sonal; Aggarwal, Diwakar; Sehrawat, Nirmala; Yadav, Mukesh; Kumar, Vikas] Maharishi Markandeshwar Deemed be Univ, Dept Biosci & Technol, Mullana 133207, Haryana, India.
   [Sharma, Varruchi] Sri Guru Gobind Singh Coll, Dept Biotechnol & Bioinformat, Chandigarh 160019, India.
   [Sharma, Ajay] Career Point Univ, Dept Chem, Tikker Kharwarian, Hamirpur 176041, Himachal Prades, India.
   [Zghair, Abdulrazzaq N.] Middle Tech Univ, Coll Hlth & Med Tech, Baghdad, Iraq.
   [Dhama, Kuldeep] ICAR Indian Vet Res Inst, Div Pathol, Izatnagar, UP, India.
   [Sharma, Aanchal] Chandigarh Univ, Univ Ctr Res & Dev, Univ Inst Biotechnol, Mohali 140413, India.
   [Sharma, Anil K.] Amity Univ, Dept Biotechnol, Sect 82 A, IT City Rd, Mohali 140306, Punjab, India.
   [Wang, Hailian] Univ Elect Sci & Technol China, Sichuan Acad Med Sci, Inst Organ Transplantat, Chengdu, Peoples R China.
   [Wang, Hailian] Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Chengdu, Peoples R China.
C3 Middle Technical University; Indian Council of Agricultural Research
   (ICAR); ICAR - Indian Veterinary Research Institute; Chandigarh
   University; University of Electronic Science & Technology of China;
   Sichuan Provincial People's Hospital; Sichuan Provincial People's
   Hospital; University of Electronic Science & Technology of China
RP Sharma, AK (corresponding author), Amity Univ, Dept Biotechnol, Sect 82 A, IT City Rd, Mohali 140306, Punjab, India.; Wang, HL (corresponding author), Univ Elect Sci & Technol China, Sichuan Acad Med Sci, Inst Organ Transplantat, Chengdu, Peoples R China.; Wang, HL (corresponding author), Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Chengdu, Peoples R China.
EM anibiotech18@gmail.com; whl322@qq.com
RI Sharma, Anil/AAP-1909-2020; KUMAR, VIKAS/IYJ-2709-2023; Aggarwal,
   Diwakar/AAA-8306-2020; Mukesh, Yadav/AAS-7088-2020; Sehrawat,
   Nirmala/AAA-7301-2020; Datta, Sonal/AGI-2356-2022; Sharma,
   Ajay/B-7086-2017; Kumar, Vikas/K-8426-2016; SHARMA, Dr
   VARRUCHI/AAU-1478-2020; Dhama, Kuldeep/B-7852-2015
OI Datta, Sonal/0000-0002-4924-9355; Sharma, Ajay/0000-0002-1555-1791;
   Yadav, Mukesh/0000-0001-8526-3747; Sharma, Anil/0000-0002-9768-1644;
   Sehrawat, Nirmala/0000-0001-7486-909X; Kumar, Vikas/0000-0002-6044-3239;
   neamah, abdultrazaaq/0009-0006-1407-6569; SHARMA, Dr
   VARRUCHI/0000-0002-0465-8075; Dhama, Kuldeep/0000-0001-7469-4752
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NR 150
TC 22
Z9 22
U1 4
U2 20
PU ELSEVIER GMBH
PI MUNICH
PA HACKERBRUCKE 6, 80335 MUNICH, GERMANY
SN 0944-7113
EI 1618-095X
J9 PHYTOMEDICINE
JI Phytomedicine
PD DEC
PY 2023
VL 121
AR 155100
DI 10.1016/j.phymed.2023.155100
EA OCT 2023
PG 11
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA W0MS6
UT WOS:001088664100001
PM 37801892
DA 2025-06-11
ER

PT J
AU Ranasinghe, WKB
   Wright, T
   Attia, J
   McElduff, P
   Doyle, T
   Bartholomew, M
   Hurley, K
   Persad, RA
AF Ranasinghe, Weranja K. B.
   Wright, Timothy
   Attia, John
   McElduff, Patrick
   Doyle, Terrence
   Bartholomew, Meegan
   Hurley, Katrina
   Persad, Rajendra A.
TI Effects of bariatric surgery on urinary and sexual function
SO BJU INTERNATIONAL
LA English
DT Article
DE obesity; bariatric surgery; laparoscopic gastric banding surgery;
   urinary incontinence; erectile function; sexual function
ID BENIGN PROSTATIC HYPERPLASIA; WEIGHT-LOSS SURGERY; ERECTILE DYSFUNCTION;
   METABOLIC SYNDROME; OBESE WOMEN; GASTRIC BYPASS; INCONTINENCE; INDEX;
   ICIQ; ASSOCIATION
AB What's known on the subject? and What does the study add?
   Obesity is a known risk factor for Urinary Incontinence. Non surgical weight loss has been shown to reduce Urinary Incontinence, but there is only limited evidence for surgically induced weight loss. This study aims to clarify the effects of surgically induced weight loss on urinary and erectile function.
   OBJECTIVE
   To investigate the effects of weight loss and time post laparoscopic gastric banding surgery (LGB) on urinary and sexual function.
   MATERIALS AND METHODS
   653 females and 145 males who underwent LGB over the last 10 years at a single centre in Australia were contacted by post and asked to complete validated questionnaires.
   RESULTS
   The pre-surgery body-mass index (BMI) was higher in males than females (47.3 vs 43.5); 65% of the females and 24% of males previously had some degree of urinary incontinence (UI). There were significant weight and BMI losses in males and females (23.2 kg and 7.51 vs 22.7 kg and 8.28; P < 0.0001). In females there were significant improvements in the ICIQ-SF (P = 0.0008) and Quality of Life (P < 0.0001) scores. For each kilogram lost there was a 0.05 improvement in the ICIQ score (P = 0.03) in females. There were also postoperative improvements in all symptoms of UI and stress incontinence in females but urge incontinence worsened, when adjusted for weight loss. In males there was no improvement in UI with weight loss after LGB. There was no relationship with time and UI in either gender; 83.3% of males reported a degree of ED before LGB. There was improvement in the IIEF score in males post LGB but there was worsening of erectile index (P = 0.005) and orgasmic function (P = 0.002) when adjusted for time. More males had started using phosphodiesterase type 5 inhibitors, post-LGB.
   CONCLUSIONS
   Surgically induced weight loss by LGB improved overall UI, quality of life and stress incontinence in females but urge incontinence worsened. There was no improvement in UI with weight-loss or overall sexual function after LGB in males. However, erectile index and orgasmic function worsened when adjusted for time. Further evaluation is required by means of larger prospective studies involving urodynamic testing.
C1 [Wright, Timothy; Doyle, Terrence] John Hunter Hosp, Melbourne, Vic, Australia.
   [Attia, John; McElduff, Patrick] Univ Newcastle, Sch Med & Publ Hlth, Melbourne, Vic, Australia.
   [Ranasinghe, Weranja K. B.] Austin Hosp, Melbourne, Vic 3084, Australia.
   [Bartholomew, Meegan] Newcastle Obes Surg Ctr, Newcastle, NSW, Australia.
   [Hurley, Katrina; Persad, Rajendra A.] Bristol Royal Infirm & Gen Hosp, Bristol, Avon, England.
C3 John Hunter Hospital; University of Newcastle; Austin Research
   Institute; Florey Institute of Neuroscience & Mental Health; Howard
   Florey Institute Affiliates; Bristol Royal Infirmary
RP Ranasinghe, WKB (corresponding author), Austin Hosp, Dept Urol, 145 Studley Rd,POB 5555, Heidelberg, Vic 3084, Australia.
EM weranja@gmail.com
RI Ranasinghe, Weranja/HHS-8150-2022; Attia, John/F-5376-2013
OI Ranasinghe, Weranja/0000-0002-4006-0388; Dao, Tu/0000-0001-6858-8347;
   Attia, John/0000-0001-9800-1308
FU Allergan Australia
FX Funding for stationary and statistical analysis provided by Allergan
   Australia.
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   [Anonymous], JAMA
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NR 33
TC 53
Z9 55
U1 0
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1464-4096
EI 1464-410X
J9 BJU INT
JI BJU Int.
PD JAN
PY 2011
VL 107
IS 1
BP 88
EP 94
DI 10.1111/j.1464-410X.2010.09509.x
PG 7
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 696CB
UT WOS:000285418400011
PM 20707800
DA 2025-06-11
ER

PT J
AU Darmon, P
   Dadoun, F
   Boullu-Ciocca, S
   Grino, M
   Alessi, MC
   Dutour, A
AF Darmon, Patrice
   Dadoun, Frederic
   Boullu-Ciocca, Sandrine
   Grino, Michel
   Alessi, Marie-Christine
   Dutour, Anne
TI Insulin resistance induced by hydrocortisone is increased in patients
   with abdominal obesity
SO AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
LA English
DT Article
DE glucocorticoid hypersensitivity; visceral obesity; metabolic effects of
   hydrocortisone
ID 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1; PLASMINOGEN-ACTIVATOR
   INHIBITOR-1; HUMAN ADIPOSE-TISSUE; SPLANCHNIC CORTISOL PRODUCTION;
   METABOLIC SYNDROME; PHYSIOLOGICAL HYPERCORTISOLEMIA; GENE-EXPRESSION;
   GLUCOCORTICOIDS; HUMANS; STRESS
AB Glucocorticoids hypersensitivity may be involved in the development of abdominal obesity and insulin resistance. Eight normal weight and eight obese women received on two occasions a 3-h intravenous infusion of saline or hydrocortisone (HC) (1.5 mu g.kg(-1).min(-1)). Plasma cortisol, insulin, and glucose levels were measured every 30 min from time(-30) (min) (time(-30)) to time(240). Free fatty acids, adiponectin, and plasminogen activator inhibitor-1 (PAI-1) levels were measured at time(-30), time(180), and time(240). At time(240), subjects underwent an insulin tolerance test to obtain an index of insulin sensitivity (K-ITT). Mean(30-240) cortisol level was similar in control and obese women after saline (74 +/- 16 vs. 75 +/- 20 mu g/l) and HC (235 +/- 17 vs. 245 +/- 47 mu g/l). The effect of HC on mean(180-240) insulin, mean(180-240) insulin resistance obtained by homeostasis model assessment (HOMA-IR), and K-ITT was significant in obese (11.4 +/- 2.0 vs. 8.2 +/- 1.3 mU/l, P < 0.05; 2.37 +/- 0.5 vs. 1.64 +/- 0.3, P < 0.05; 2.81 +/- 0.9 vs. 3.32 +/- 1.02%/min, P < 0.05) but not in control women (3.9 +/- 0.6 vs. 2.8 +/- 0.5 mU/l; 0.78 +/- 0.1 vs. 0.49 +/- 0.1; 4.36 +/- 1.1 vs. 4.37 +/- 1.2%/min). In the whole population, the quantity of visceral fat, estimated by computerized tomography scan, was correlated with the increment of plasma insulin and HOMA-IR during HC infusion [Delta mean(30-240) insulin (r = 0.61, P < 0.05), Delta mean(30-240) HOMA-IR (r = 0.66, P < 0.01)]. The increase of PAI-1 between time(180) and time(240) after HC was higher in obese women (+25%) than in controls (+12%) (P < 0.05), whereas no differential effect between groups was observed for free fatty acids or adiponectin. A moderate hypercortisolism, equivalent to that induced by a mild stress, has more pronounced consequences on insulin sensitivity in abdominally obese women than in controls. These deleterious effects are correlated with the amount of visceral fat.
C1 Hop Nord Marseille, Endocrinol & Nutr Dept, F-13915 Marseille, France.
   Univ Mediterranee, Fac Med, INSERM, Unite Mixte Rech 626,Lab Hematol, Marseille, France.
   Hop Nord Marseille, Ctr Clin Invest, Marseille, France.
C3 Aix-Marseille Universite; Assistance Publique-Hopitaux de Marseille;
   Aix-Marseille Universite; Institut National de la Sante et de la
   Recherche Medicale (Inserm); Aix-Marseille Universite; Assistance
   Publique-Hopitaux de Marseille
RP Darmon, P (corresponding author), Hop Nord Marseille, Endocrinol & Nutr Dept, F-13915 Marseille, France.
EM pdarmon@ap-hm.fr
RI Grino, Michel/O-5361-2017; Dutour, Anne/AAK-4460-2020; ALESSI,
   Marie-christine/AAK-3582-2020
OI Dutour, Anne/0000-0002-5844-5884; DADOUN, FREDERIC/0000-0002-2370-0611;
   ALESSI, Marie-christine/0000-0003-3927-5792; Darmon,
   Patrice/0000-0003-1726-2296
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NR 51
TC 52
Z9 58
U1 0
U2 2
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0193-1849
J9 AM J PHYSIOL-ENDOC M
JI Am. J. Physiol.-Endocrinol. Metab.
PD NOV
PY 2006
VL 291
IS 5
BP E995
EP E1002
DI 10.1152/ajpendo.00654.2005
PG 8
WC Endocrinology & Metabolism; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Physiology
GA 092OC
UT WOS:000241106200016
PM 16772320
DA 2025-06-11
ER

PT J
AU Mobley, CB
   Toedebusch, RG
   Lockwood, CM
   Heese, AJ
   Zhu, CA
   Krieger, AE
   Cruthirds, CL
   Hofheins, JC
   Company, JM
   Wiedmeyer, CE
   Kim, DY
   Booth, FW
   Roberts, MD
AF Mobley, C. Brooks
   Toedebusch, Ryan G.
   Lockwood, Christopher M.
   Heese, Alexander J.
   Zhu, Conan
   Krieger, Anna E.
   Cruthirds, Clayton L.
   Hofheins, John C.
   Company, Joseph M.
   Wiedmeyer, Charles E.
   Kim, Dae Y.
   Booth, Frank W.
   Roberts, Michael D.
TI Herbal adaptogens combined with protein fractions from bovine colostrum
   and hen egg yolk reduce liver TNF-α expression and protein carbonylation
   in Western diet feeding in rats
SO NUTRITION & METABOLISM
LA English
DT Article
DE Liver; Inflammation; Oxidative stress; RNA-seq
ID METABOLIC SYNDROME; NONALCOHOLIC STEATOHEPATITIS; INSULIN SENSITIVITY;
   HEPATIC STEATOSIS; OXIDATIVE STRESS; VITAMIN-C; RESPONSES; RESVERATROL;
   IMPROVES; MUSCLE
AB Background: We examined if a purported anti-inflammatory supplement (AF) abrogated Western-diet (WD)-induced liver pathology in rats. AF contained: 1) protein concentrates from bovine colostrum and avian egg yolk; 2) herbal adaptogens and antioxidants; and 3) acetyl-L-carnitine.
   Methods: Nine month-old male Brown Norway rats were allowed ad libitum access to WD for 41-43 days and randomly assigned to WD + AF feeding twice daily for the last 31-33 days (n = 8), or WD and water-placebo feeding twice daily for the last 31-33 days (n = 8). Rats fed a low-fat/low-sucrose diet (CTL, n = 6) for 41-43 days and administered a water-placebo twice daily for the last 31-33 days were also studied. Twenty-four hours following the last gavage-feed, liver samples were analyzed for: a) select mRNAs (via RT PCR) as well as genome wide mRNA expression patterns (via RNA-seq); b) lipid deposition; and, c) protein carbonyl and total antioxidant capacity (TAC). Serum was also examined for TAC, 8-isoprostane and clinical chemistry markers.
   Results: WD + AF rats experienced a reduction in liver Tnf-alpha mRNA (-2.8-fold, p < 0.01). Serum and liver TAC was lower in WD + AF versus WD and CTL rats (p < 0.05), likely due to exogenous antioxidant ingredients provided through AF as evidenced by a tendency for mitochondrial SOD2 mRNA to increase in WD + AF versus CTL rats (p = 0.07). Liver fat deposition nor liver protein carbonyl content differed between WD + AF versus WD rats, although liver protein carbonyls tended to be lower in WD + AF versus CTL rats (p = 0.08). RNA-seq revealed that 19 liver mRNAs differed between WD + AF versus WD when both groups were compared with CTL rats (+/- 1.5-fold, p < 0.01). Bioinformatics suggest that AF prevented WD-induced alterations in select genes related to the transport and metabolism of carbohydrates in favor of select genes related to lipid transport and metabolism. Finally, serum clinical safety markers and liver pathology (via lesion counting) suggests that chronic consumption of AF was well tolerated.
   Conclusions: AF supplementation elicits select metabolic, anti-inflammatory, and anti-oxidant properties which was in spite of WD feeding and persisted up to 24 hours after receiving a final dose.
C1 [Mobley, C. Brooks; Roberts, Michael D.] Auburn Univ, Sch Kinesiol, Auburn, AL 36849 USA.
   [Toedebusch, Ryan G.; Heese, Alexander J.; Zhu, Conan; Krieger, Anna E.; Cruthirds, Clayton L.; Hofheins, John C.; Company, Joseph M.; Booth, Frank W.; Roberts, Michael D.] Univ Missouri, Dept Biomed Sci, Columbia, MO USA.
   [Lockwood, Christopher M.] 4LIFE Res, Sandy, UT USA.
   [Wiedmeyer, Charles E.; Kim, Dae Y.] Univ Missouri, Dept Vet Pathobiol, Columbia, MO USA.
   [Booth, Frank W.] Univ Missouri, Dept Nutr & Exercise Physiol, Columbia, MO USA.
   [Booth, Frank W.] Univ Missouri, Dept Med Pharmacol & Physiol, Columbia, MO USA.
   [Booth, Frank W.] Univ Missouri, Dalton Cardiovasc Res Ctr, Columbia, MO USA.
C3 Auburn University System; Auburn University; University of Missouri
   System; University of Missouri Columbia; University of Missouri System;
   University of Missouri Columbia; University of Missouri System;
   University of Missouri Columbia; University of Missouri System;
   University of Missouri Columbia; University of Missouri System;
   University of Missouri Columbia
RP Roberts, MD (corresponding author), Auburn Univ, Sch Kinesiol, Auburn, AL 36849 USA.
EM mdr0024@auburn.edu
RI Mobley, Christopher/AAC-2123-2020; Lockwood, Christopher/A-8136-2018
OI Mobley, C. Brooks/0000-0002-4045-9962; Lockwood,
   Christopher/0000-0002-4002-4301
FU 4Life Research, Inc. (Sandy, UT)
FX All experiments were performed at the University of Missouri, but all
   data analyses and manuscript write-up were primarily performed by CBM
   and MDR (principal investigator) at Auburn University. Rats and all
   analytical costs were funded by 4Life Research, Inc. (Sandy, UT).
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NR 53
TC 7
Z9 8
U1 0
U2 19
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1743-7075
J9 NUTR METAB
JI Nutr. Metab.
PD APR 23
PY 2014
VL 11
AR 19
DI 10.1186/1743-7075-11-19
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA AH1BE
UT WOS:000335853800001
PM 24822076
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Mühling, O
   Jerosch-Herold, M
   Näbauer, M
   Wilke, N
AF Mühling, O
   Jerosch-Herold, M
   Näbauer, M
   Wilke, N
TI Assessment of ischemic heart disease using magnetic resonance first-pass
   perfusion imaging
SO HERZ
LA English
DT Article
DE myocardial perfusion; magnetic resonance; endocardial perfusion;
   ischemic heart disease
ID CORONARY-ARTERY-DISEASE; MYOCARDIAL BLOOD-FLOW; ALLOGRAFT VASCULOPATHY;
   VASODILATOR RESERVE; MRI; TRANSPLANTATION; QUANTIFICATION; DYSFUNCTION;
   ADENOSINE; STRESS
AB Methods: Cardiovascular magnetic resonance (MR) perfusion imaging has matured to a point where it can be routinely applied to assess patients with coronary artery disease and ischemic cardiomyopathy. The method has been compared to invasive, catheter-based as well as other noninvasive imaging modalities (echocardiography, single-photon emission computed tomography [SPECT], and positron emission tomography [PET]) for the evaluation of patients with coronary artery disease. Besides qualitative evaluation of MR perfusion images, an absolute quantification of global, regional and transmural myocardial perfusion is possible. A relative or absolute myocardial perfusion reserve has been determined noninvasively with MR perfusion imaging, and can provide good agreement with the invasive assessment. Based on the perfusion reserve, the severity of an epicardial coronary stenosis can be evaluated in patients with known or suspected coronary artery disease. Besides the absence of radiation exposure, MR perfusion imaging offers good temporal and excellent spatial resolution. In particular, the spatial resolution increases the sensitivity and specificity for the detection of coronary artery disease. New parameters such as the "endo-/epimyocardial resting perfusion ratio", may under some circumstances sufficiently enhance the sensitivity for detecting an abnormal perfusion, and thus avoid potentially harmful and expensive stress testing in patients with suspected ischemic heart disease. New revascularization modalities such as therapeutic angiogenesis need to be matched by sensitive imaging tools to prove their benefits. Thus, the optimization of therapeutic angiogenesis may profit from the diagnostic advantages provided by MR perfusion imaging. Furthermore, MR might yield new insights into the pathophysiology of cardiac diseases such as "syndrome X", or might help in the repetitive assessment of heart transplant recipients, possibly obviating the need for further invasive testing.
   Conclusion: The breadth of cardiac MRI allows the combined noninvasive assessment of myocardial perfusion, function, as well as myocardial viability. The combination gives MRI a unique and strong position in the field of noninvasive diagnostic cardiology.
C1 Univ Munich, Med Hosp & Clin Grosshadern 1, D-80539 Munich, Germany.
   Univ Minnesota, Dept Radiol, Sect Cardiovasc MRI, Minneapolis, MN 55455 USA.
   Univ Florida, Dept Radiol, Jacksonville, FL 32209 USA.
C3 University of Munich; University of Minnesota System; University of
   Minnesota Twin Cities; State University System of Florida; University of
   Florida
EM omuehlin@helios.med.uni-muenchen.de
RI Jerosch-Herold, Michael/R-9824-2019
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NR 45
TC 21
Z9 24
U1 0
U2 0
PU URBAN & VOGEL
PI MUNICH
PA NEUMARKTER STRASSE 43, D-81673 MUNICH, GERMANY
SN 0340-9937
EI 1615-6692
J9 HERZ
JI Herz
PD MAR
PY 2003
VL 28
IS 2
BP 82
EP 89
DI 10.1007/s00059-003-2458-z
PG 8
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 666RX
UT WOS:000182191200003
PM 12669221
DA 2025-06-11
ER

PT J
AU Mann, V
   Sundaresan, A
   Shishodia, S
AF Mann, Vivek
   Sundaresan, Alamelu
   Shishodia, Shishir
TI Overnutrition and Lipotoxicity: Impaired Efferocytosis and Chronic
   Inflammation as Precursors to Multifaceted Disease Pathogenesis
SO BIOLOGY-BASEL
LA English
DT Review
DE overnutrition; lipotoxicity; oxidative stress; efferocytosis; chronic
   inflammation
ID APOPTOTIC CELLS; SERIES LIPOTOXICITY; ADIPOSE-TISSUE; ENERGY-BALANCE;
   OBESITY; HEALTH; PHAGOCYTOSIS; FERROPTOSIS; DYSFUNCTION; MECHANISMS
AB Simple Summary Overnutrition, characterized by an excessive caloric intake, often leads to lipotoxicity, a condition where lipids accumulate abnormally in non-adipose tissues. This phenomenon contributes to impaired efferocytosis, the process by which cells remove dead or dying cells, and subsequently triggers chronic inflammation. These interconnected factors serve as precursors to a multitude of disease pathologies. The overabundance of nutrients overwhelms cellular mechanisms, disrupting the delicate balance required for proper efferocytosis. As a result, apoptotic cells linger, perpetuating inflammation and triggering a cascade of detrimental effects on tissue function and homeostasis. Chronic inflammation, a hallmark of various diseases, including cardiovascular disorders, diabetes, and neurodegenerative conditions, underscores the significance of understanding the underlying mechanisms linking overnutrition, impaired efferocytosis, and disease pathogenesis. By elucidating these pathways, researchers aim to develop targeted interventions to mitigate the adverse health outcomes associated with overnutrition-induced lipotoxicity, offering potential avenues for prevention and treatment to combat multifaceted diseases.Abstract Overnutrition, driven by the consumption of high-fat, high-sugar diets, has reached epidemic proportions and poses a significant global health challenge. Prolonged overnutrition leads to the deposition of excessive lipids in adipose and non-adipose tissues, a condition known as lipotoxicity. The intricate interplay between overnutrition-induced lipotoxicity and the immune system plays a pivotal role in the pathogenesis of various diseases. This review aims to elucidate the consequences of impaired efferocytosis, caused by lipotoxicity-poisoned macrophages, leading to chronic inflammation and the subsequent development of severe infectious diseases, autoimmunity, and cancer, as well as chronic pulmonary and cardiovascular diseases. Chronic overnutrition promotes adipose tissue expansion which induces cellular stress and inflammatory responses, contributing to insulin resistance, dyslipidemia, and metabolic syndrome. Moreover, sustained exposure to lipotoxicity impairs the efferocytic capacity of macrophages, compromising their ability to efficiently engulf and remove dead cells. The unresolved chronic inflammation perpetuates a pro-inflammatory microenvironment, exacerbating tissue damage and promoting the development of various diseases. The interaction between overnutrition, lipotoxicity, and impaired efferocytosis highlights a critical pathway through which chronic inflammation emerges, facilitating the development of severe infectious diseases, autoimmunity, cancer, and chronic pulmonary and cardiovascular diseases. Understanding these intricate connections sheds light on potential therapeutic avenues to mitigate the detrimental effects of overnutrition and lipotoxicity on immune function and tissue homeostasis, thereby paving the way for novel interventions aimed at reducing the burden of these multifaceted diseases on global health.
C1 [Mann, Vivek; Sundaresan, Alamelu; Shishodia, Shishir] Texas Southern Univ, Dept Biol, Houston, TX 77004 USA.
C3 Texas Southern University
RP Shishodia, S (corresponding author), Texas Southern Univ, Dept Biol, Houston, TX 77004 USA.
EM vivek.mann@tsu.edu; alamelu.sundaresan@tsu.edu;
   shishir.shishodia@tsu.edu
FU Center for Biomedical and Minority Institutions Program
FX We extend our sincere appreciation to Rehan Memon and Sarah F. Banday
   from Clement High School, Sugarland, Texas, whose dedication, and hard
   work significantly shaped this manuscript. Their contributions in
   drafting, figure preparation, literature research, and content revision
   enriched the quality of our work. We commend their commitment to
   scientific inquiry and interdisciplinary collaboration, which
   undoubtedly contributed to the success of this project. Figures were
   generated using BioRender.com.
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NR 178
TC 6
Z9 6
U1 2
U2 14
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2079-7737
J9 BIOLOGY-BASEL
JI Biology-Basel
PD APR
PY 2024
VL 13
IS 4
AR 241
DI 10.3390/biology13040241
PG 25
WC Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics
GA OW6Z8
UT WOS:001210367100001
PM 38666853
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Jahrami, H
   Faris, MA
   Ghazzawi, HA
   Saif, Z
   Habib, L
   Shivappa, N
   Hébert, JR
AF Jahrami, Haitham
   Faris, Mo'ez Al-Islam
   Ghazzawi, Hadeel Ali
   Saif, Zahra
   Habib, Layla
   Shivappa, Nitin
   Hebert, James R.
TI Increased Dietary Inflammatory Index Is Associated with Schizophrenia:
   Results of a Case-Control Study from Bahrain
SO NUTRIENTS
LA English
DT Article
DE dietary inflammatory index (DII); schizophrenia; case-control study
ID C-REACTIVE PROTEIN; DEPRESSIVE SYMPTOMS; BIPOLAR DISORDER;
   MENTAL-DISORDERS; 1ST-EPISODE SCHIZOPHRENIA; INSULIN-RESISTANCE;
   COGNITIVE FUNCTION; METABOLIC SYNDROME; TOBACCO SMOKING; RISK-FACTORS
AB Background: Several studies have indicated that chronic low-grade inflammation is associated with the development of schizophrenia. Given the role of diet in modulating inflammatory markers, excessive caloric intake and increased consumption of pro-inflammatory components such as calorie-dense, nutrient-sparse foods may contribute toward increased rates of schizophrenia. This study aimed to examine the association between dietary inflammation, as measured by the dietary inflammatory index (DII (R)), and schizophrenia. Methods: A total of 120 cases attending the out-patient department in the Psychiatric Hospital/Bahrain were recruited, along with 120 healthy controls matched on age and sex. The energy-adjusted DII (E-DII) was computed based on dietary intake assessed using a comprehensive food frequency questionnaire (FFQ). Logistic regression was used to estimate odds ratios and 95% confidence intervals, adjusting for potential confounders including age, sex, body mass index, education, employment, diabetes, hypertension, and cardiovascular disease with E-DII expressed both as a continuous variable and categorized as quartiles. Results: The mean E-DII score for the entire sample was 1.79 +/- 1.52, indicating a generally pro-inflammatory diet. The cases with schizophrenia appeared to have a higher E-DII score compared to controls: 1.99 +/- 1.39 vs. 1.60 +/- 1.38, respectively (p = 0.009). For every one unit increase in the E-DII score, the odds of having schizophrenia increased by 62% (OR 1.62; 95% CI 1.17-2.26). Similarly, increased risk was observed when the E-DII was used as quartiles, with participants in most pro-inflammatory quartile 4 being nearly 6 times more likely to be schizophrenic than participants in the most anti-inflammatory group quartile 1 (OR 5.96; 1.74-20.38; p-trend = 0.01). Conclusions: The data suggest that a pro-inflammatory diet, as indicated by increasing E-DII score, is associated with schizophrenia. This is the first study to examine the association between the DII and schizophrenia in a Middle Eastern population. Although these results are consistent with findings from research conducted in depression, additional studies are required before generalizing the findings to other populations.
C1 [Jahrami, Haitham; Saif, Zahra; Habib, Layla] Minist Hlth, Manama, Bahrain.
   [Jahrami, Haitham] Arabian Gulf Univ, Coll Med & Med Sci, Manama, Bahrain.
   [Faris, Mo'ez Al-Islam] Univ Sharjah, Coll Hlth Sci, Dept Clin Nutr & Dietet, RIMHS, POB 27272, Sharjah, U Arab Emirates.
   [Ghazzawi, Hadeel Ali] Univ Jordan, Fac Agr, Dept Nutr & Food Technol, Amman, Jordan.
   [Shivappa, Nitin; Hebert, James R.] Univ South Carolina, Canc Prevent & Control Program, Columbia, SC 29208 USA.
   [Shivappa, Nitin; Hebert, James R.] Univ South Carolina, Arnold Sch Publ Hlth, Dept Epidemiol & Biostat, Columbia, SC 29208 USA.
   [Shivappa, Nitin; Hebert, James R.] Connecting Hlth Innovat LLC, Columbia, SC 29201 USA.
C3 Ministry of Health - Bahrain; Arabian Gulf University; University of
   Sharjah; University of Jordan; University of South Carolina System;
   University of South Carolina Columbia; University of South Carolina
   System; University of South Carolina Columbia; Connecting Health
   Innovations LLC
RP Jahrami, H (corresponding author), Minist Hlth, Manama, Bahrain.; Jahrami, H (corresponding author), Arabian Gulf Univ, Coll Med & Med Sci, Manama, Bahrain.
EM hjahrami@health.gov.bh
RI Louafi, Habib/HNS-5825-2023; Shivappa, Nitin/X-2215-2018; Jahrami,
   Haitham/JVO-6632-2024; Hebert, James/IUO-5628-2023; Ghazzawi,
   Hadeel/ABG-1471-2021; Ghazzawi, Hadeel/A-4890-2018; Faris,
   MoezAlIslam/M-9682-2017
OI Ghazzawi, Hadeel/0000-0003-3045-4153; Jahrami,
   Haitham/0000-0001-8990-1320; Faris, MoezAlIslam/0000-0002-7970-2616
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NR 75
TC 10
Z9 10
U1 1
U2 7
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD AUG
PY 2019
VL 11
IS 8
AR 1867
DI 10.3390/nu11081867
PG 14
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nutrition & Dietetics
GA IV8HH
UT WOS:000484506000042
PM 31405205
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Ng, TP
   Hai, S
   Gao, Q
   Gwee, X
   Chua, DQL
   Yap, P
   Yap, KB
   Wee, SL
AF Ng, Tze-Pin
   Hai, Shan
   Gao, Qi
   Gwee, Xinyi
   Chua, Denise Qian Ling
   Yap, Philip
   Yap, Keng Bee
   Wee, Shiou Liang
TI The Elderly Nutritional Index for Geriatric Malnutrition Assessment
   (ENIGMA): concurrent, construct and predictive validity in an external
   evaluation cohort of community-dwelling older persons
SO BRITISH JOURNAL OF NUTRITION
LA English
DT Article
DE MNA; GNRI; Functional dependence; Mortality; Primary care
ID RISK INDEX; SCREENING TOOLS; ASSESSMENT MNA; ADULTS; VALIDATION;
   PREVALENCE; SETTINGS; FALLS
AB We previously developed a malnutrition risk index, the Elderly Nutritional Index for Geriatric Malnutrition Assessment (ENIGMA) with good predictive accuracy for mortality risk in an original population cohort (SLAS1). Herein, we further evaluate the concurrent and predictive validity of the ENIGMA construct in an external validation cohort (SLAS-2) of 2824 community-dwelling older adults aged 55+ years. They were assessed on the ENIGMA index, Mini Nutritional Assessment-Short Form (MNA-SF) and the Geriatric Nutritional Risk Index (GNRI), known correlates of malnutrition, and baseline and follow-up functional dependency and 10-year mortality risk. Higher ENIGMA risk categories were significantly associated (P < 0 center dot 001) with lower education, living alone, smoking, low physical activity, BMI < 18 center dot 5 kg/m(2), poorer muscle strength and functional mobility, exhaustion, physical frailty, homocysteine, glomerular filtration rate, Hb, red and white blood cell counts, platelets, systemic inflammation indexes, metabolic syndrome, CVD, cognitive impairment and depressive symptoms (Geriatric Depression Scale >= 5). ENIGMA scores showed statistically significant (P < 0 center dot 001) correlations but low-to-moderate concordance with MNA-SF (r = 0 center dot 148, agreement = 45 center dot 9 %, kappa = 0 center dot 085) and GNRI scores (r = 0 center dot 156, agreement = 45 center dot 8 %, kappa = 0 center dot 096). Controlling for known correlates of malnutrition, only high-risk ENIGMA among the indexes significantly predicted baseline functional dependency (OR = 1 center dot 64, 95 % CI 1 center dot 01, 2 center dot 65) and mortality (hazard ratio = 1 center dot 65 (95 % CI 1 center dot 04, 2 center dot 62). ENIGMA marginally out-performed MNA-SF and GNRI in predicting baseline functional dependency (AUC: 0 center dot 625 v. 0 center dot 584 v. 0 center dot 526), follow-up functional dependency (AUC: 0 center dot 594 v. 0 center dot 525 v. 0 center dot 479) and 10-year mortality risk (AUC: 0 center dot 641 v. 0 center dot 596 v. 0 center dot 595). The concurrent and predictive validity of the ENIGMA construct is replicated in an external evaluation study of community-dwelling older persons.
C1 [Ng, Tze-Pin; Gao, Qi; Gwee, Xinyi; Chua, Denise Qian Ling] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Psychol Med, Singapore, Singapore.
   [Ng, Tze-Pin; Wee, Shiou Liang] Geriatr Educ & Res Inst, Singapore, Singapore.
   [Hai, Shan] Sichuan Univ, West China Hosp, Ctr Gerontol & Geriatr, Chengdu, Peoples R China.
   [Yap, Philip] Khoo Teck Puat Hosp, Geriatr Med, Singapore, Singapore.
   [Yap, Keng Bee] Ng Teng Fong Gen Hosp, Med, Singapore, Singapore.
   [Wee, Shiou Liang] Singapore Inst Technol, Singapore, Singapore.
C3 National University of Singapore; Sichuan University; Singapore
   Institute of Technology
RP Ng, TP (corresponding author), Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Psychol Med, Singapore, Singapore.; Ng, TP (corresponding author), Geriatr Educ & Res Inst, Singapore, Singapore.
EM pcmngtp@nus.edu.sg
RI Wee, Shiou-Liang/H-7115-2019
OI Gwee, Xinyi/0000-0003-3570-1352; Wee, Shiou-Liang/0000-0002-7853-4112;
   Ng, Tze Pin/0000-0001-9585-855X
FU Agency for Science Technology and Research (A * STAR) Biomedical
   Research Council [BMRC/08/1/21/19/567]; National Medical Research
   Council [NMRC/1108/2007, NMRC/CIRG/1409/2014]; Geylang East Home for the
   Aged; Presbyterian Community Services; St Luke's Eldercare Services;
   Thye Hua Kwan Moral Society (Moral Neighbourhood Links); Yuhua
   Neighbourhood Link; Henderson Senior Citizens' Home; NTUC Eldercare
   Co-op Ltd.; Thong Kheng Seniors Activity Centre (Queenstown Centre);
   Redhill Moral Seniors Activity Centre
FX This work was supported by research grants from the Agency for Science
   Technology and Research (A * STAR) Biomedical Research Council
   (BMRC/08/1/21/19/567) and the National Medical Research Council
   (NMRC/1108/2007; NMRC/CIRG/1409/2014). We thank the following voluntary
   welfare organisations for their support: Geylang East Home for the Aged,
   Presbyterian Community Services, St Luke's Eldercare Services, Thye Hua
   Kwan Moral Society (Moral Neighbourhood Links), Yuhua Neighbourhood
   Link, Henderson Senior Citizens' Home, NTUC Eldercare Co-op Ltd, Thong
   Kheng Seniors Activity Centre (Queenstown Centre) and Redhill Moral
   Seniors Activity Centre.
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NR 31
TC 5
Z9 5
U1 1
U2 7
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1145
EI 1475-2662
J9 BRIT J NUTR
JI Br. J. Nutr.
PD AUG 14
PY 2022
VL 128
IS 3
BP 509
EP 520
AR PII S0007114521003433
DI 10.1017/S0007114521003433
EA SEP 2021
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 3L9HD
UT WOS:000744705200001
PM 34486958
DA 2025-06-11
ER

PT J
AU Wang, W
   Yang, XB
   Liang, JB
   Liao, M
   Zhang, HY
   Qin, X
   Mo, LJ
   Lv, WX
   Mo, ZN
AF Wang, Wei
   Yang, Xiaobo
   Liang, Jianbo
   Liao, Ming
   Zhang, Haiying
   Qin, Xue
   Mo, Linjian
   Lv, Wenxin
   Mo, Zengnan
TI Cigarette smoking has a positive and independent effect on testosterone
   levels
SO HORMONES-INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM
LA English
DT Article
DE Cigarette Smoking; Free testosterone; Sex hormone-binding globulin;
   Total testosterone
ID HORMONE-BINDING GLOBULIN; LOW SERUM TESTOSTERONE; LIFE-STYLE FACTORS;
   MIDDLE-AGED MEN; BIOAVAILABLE TESTOSTERONE; ENDOGENOUS TESTOSTERONE;
   LUTEINIZING-HORMONE; SEX-HORMONES; RISK; HYPOGONADISM
AB Previous studies have suggested that testosterone levels are linked to a variety of diseases, such as cardiovascular disease, type-2 diabetes, the metabolic syndrome, erectile dysfunction, depression, stroke and osteoporosis. Since cigarette smoking is a major health problem and highly prevalent among men, several groups have studied the effects of cigarette smoking on testosterone levels in men. However, the results have been conflicting. Our objectives were to examine the association of cigarette smoking and serum levels of sex hormone-binding globulin (SHBG), total testosterone (TT) and free testosterone (FT) in a large male population. Data from 2,021 men (989 nonsmokers and 1,032 smokers), aged 20-69, were collected from the Fangchenggang Area Male Health and Examination survey using an in-person interview and self-administered questionnaires from September to December, 2009. We have found the following: (a) smokers had significantly higher TT and FT levels compared to nonsmokers, even after stratification as per age, BMI, triglycerides and alcohol consumption. (b) Both TT (r = -0.083, P <0.001) and FT (r = -0.271, P <0.001) levels were negatively correlated to the amount of tobacco exposure. (c) Smoking was an independent influencing factor for the levels of both TT (unadjusted OR = 1.64, 95% CI: 1.33-2.01, P <0.001; adjusted OR = 1.69, 95% CI: 1.34-2.13, P <0.001) and FT (unadjusted OR = 1.32, 95% CI: 1.08-1.61, P = 0.007; adjusted OR = 1.27, 95% CI: 1-1.61, P = 0.050) levels in multivariate logistic regression models before and after adjusting for age, BMI, fasting blood glucose, triglycerides, alcohol consumption and estradiol. (d) Smoking was not found to be an independent predictor of SHBG level after adjustment for confounders in multivariate regression model (P > 0.05), although a positive association between increasing pack-years and SHBG level was observed (r = 0.174, P <0.001). More research is needed to elucidate the biological mechanisms and clinical significance of these associations.
C1 [Wang, Wei; Liang, Jianbo; Mo, Linjian; Mo, Zengnan] Guangxi Med Univ, Peoples Hosp Guangxi Zhuang Autonomous Reg, Dept Urol, Nanning, Guangxi Zhuang, Peoples R China.
   [Yang, Xiaobo; Liao, Ming; Zhang, Haiying; Qin, Xue; Mo, Linjian; Lv, Wenxin; Mo, Zengnan] Guangxi Med Univ, Ctr Genom & Personalized Med, Nanning, Guangxi Zhuang, Peoples R China.
   [Yang, Xiaobo; Zhang, Haiying] Guangxi Med Univ, Sch Publ Hlth, Dept Occupat Hlth & Environm Hlth, Nanning, Guangxi Zhuang, Peoples R China.
   [Qin, Xue] Guangxi Med Univ, Affiliated Hosp 1, Dept Clin Lab, Nanning, Guangxi Zhuang, Peoples R China.
C3 Guangxi Medical University; Guangxi Medical University; Guangxi Medical
   University; Guangxi Medical University
RP Mo, ZN (corresponding author), Guangxi Med Univ, Peoples Hosp Guangxi Zhuang Autonomous Reg, Dept Urol, Nanning, Guangxi Zhuang, Peoples R China.
EM zengnanmo@hotmail.com
RI Yang, Xiaobo/G-3854-2016; Liao, Ming/LEL-9197-2024; qin,
   xue/KQV-3701-2024
OI mo, zengnan/0000-0002-3047-3138
FU National Natural Science Foundation of China [30945204, 81060234]; Key
   Program and University Talents Highland Innovation Team of Guangxi
   [2012012D003, GJR201147-09]; Chairman Science and Technology Fund;
   Tackle Program of Guangxi [1116-03, GKG1298003-07-01]; Guangxi Science
   Fund for Distinguished Young Scholars [2012GXNS-FFA060009]; Guangxi
   Provincial Department of Finance and Education [2009GJCJ150]
FX This study was partially supported by grants from the National Natural
   Science Foundation of China (30945204, 81060234), Key Program and
   University Talents Highland Innovation Team of Guangxi (2012012D003,
   GJR201147-09), Chairman Science and Technology Fund and Tackle Program
   of Guangxi (1116-03, GKG1298003-07-01), Guangxi Science Fund for
   Distinguished Young Scholars (2012GXNS-FFA060009), Guangxi Provincial
   Department of Finance and Education (2009GJCJ150). The funders had no
   role in study design, data collection and analysis, decision to publish,
   or preparation of the manuscript.
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NR 46
TC 53
Z9 55
U1 0
U2 9
PU SPRINGER INTERNATIONAL PUBLISHING AG
PI CHAM
PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND
SN 1109-3099
EI 2520-8721
J9 HORM-INT J ENDOCRINO
JI Horm.-Int. J. Endocrinol. Metab.
PD OCT-DEC
PY 2013
VL 12
IS 4
BP 567
EP 577
DI 10.14310/horm.2002.1445
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 295OM
UT WOS:000330125400010
PM 24457405
OA Bronze
DA 2025-06-11
ER

PT J
AU Kemp, DE
   Gao, KM
   Chan, PK
   Ganocy, SJ
   Findling, RL
   Calabrese, JR
AF Kemp, David E.
   Gao, Keming
   Chan, Philip K.
   Ganocy, Stephen J.
   Findling, Robert L.
   Calabrese, Joseph R.
TI Medical comorbidity in bipolar disorder: relationship between illnesses
   of the endocrine/metabolic system and treatment outcome
SO BIPOLAR DISORDERS
LA English
DT Article
DE endocrine; inflammation; insulin resistance; lithium; medical
   comorbidity; obesity; substance use disorders; treatment response;
   valproate
ID METABOLIC SYNDROME; RATING-SCALE; PSYCHIATRIC-DISORDERS; DEPRESSIVE
   SYMPTOMS; BODY-COMPOSITION; SLEEP-APNEA; I-DISORDER; OBESITY;
   PREVALENCE; BURDEN
AB Objective:
   The present study examined the relationship between medical burden in bipolar disorder and several indicators of illness severity and outcome. It was hypothesized that illnesses of the endocrine/metabolic system would be associated with greater psychiatric symptom burden and would impact the response to treatment with lithium and valproate.
   Methods:
   Data were analyzed from two studies evaluating lithium and valproate for rapid-cycling presentations of bipolar I and II disorder. General medical comorbidity was assessed by the Cumulative Illness Rating Scale (CIRS). Descriptive statistics and logistic regression analyses were conducted to explore the relationships between medical burden, body mass index (BMI), substance use disorder status, and depressive symptom severity.
   Results:
   Of 225 patients enrolled, 41.8% had a recent substance use disorder, 50.7% were male, and 69.8% had bipolar I disorder. The mean age of the sample was 36.8 (SD = 10.8) years old. The mean number of comorbid medical disorders per patient was 2.5 (SD = 2.5), and the mean CIRS total score was 4.3 (SD = 3.1). A significant positive correlation was observed between baseline depression severity and the number of organ systems affected by medical illness (p = 0.04). Illnesses of the endocrine/metabolic system were inversely correlated with remission from depressive symptoms (p = 0.02), and obesity was specifically associated with poorer treatment outcome. For every 1-unit increase in BMI, the likelihood of response decreased by 7.5% [odds ratio (OR) = 0.93, 95% confidence interval (CI): 0.87- 0.99; p = 0.02] and the likelihood of remission decreased by 7.3% (OR = 0.93, 95% CI: 0.87-0.99; p = 0.03). The effect of comorbid substance use on the likelihood of response differed significantly according to baseline BMI. The presence of a comorbid substance use disorder resulted in lower odds of response, but only among patients with a BMI >= 23 (p = 0.02).
   Conclusion:
   Among patients with rapid-cycling bipolar disorder receiving lithium and valproate, endocrine/metabolic illnesses, including overweight and obesity, appear to be associated with greater depressive symptom severity and poorer treatment outcomes.
C1 [Kemp, David E.; Gao, Keming; Chan, Philip K.; Ganocy, Stephen J.; Findling, Robert L.; Calabrese, Joseph R.] Case Western Reserve Univ, Univ Hosp Case Med Ctr, Cleveland, OH 44106 USA.
C3 University System of Ohio; Case Western Reserve University; Case Western
   Reserve University Hospital
RP Kemp, DE (corresponding author), Case Western Reserve Univ, 10524 Euclid Ave,12th Floor, Cleveland, OH 44106 USA.
EM kemp.david@gmail.com
RI Gao, Keming/W-6017-2019
FU International Society for Bipolar Disorders Research Fellowship; NIH
   [1KL2RR024990, R01 MH-50165, P20 MH-66054]; Abbott; AstraZeneca;
   GlaxoSmithKline; Eli Lilly Co; Addrenex; Bristol-Myers Squibb; Forest;
   Johnson Johnson; Neuropharm; Novartis; Organon; Otsuka; Pfizer;
   Sanofi-aventis; Sepracore; Shire; Solvay; Supernus Pharmaceuticals;
   Validus; Wyeth; France Foundation; Janssen; Servier; Solvay/Wyeth
FX Funding for this study was provided by the International Society for
   Bipolar Disorders Research Fellowship Award (DEK), and in part by NIH
   grants 1KL2RR024990 (DEK), R01 MH-50165 (JRC), and P20 MH-66054 (JRC and
   RLF).DEK has acted as a consultant to Bristol-Myers Squibb and has
   served on a speakers bureau for AstraZeneca and Pfizer. KG has received
   grant support and/or honoraria from Abbott, AstraZeneca, and
   GlaxoSmithKline; has served as a consultant to Schering Plough; and has
   served on a speakers bureau for Pfizer. SJG has received grant support
   from AstraZeneca and Eli Lilly & Co. RLF receives or has received
   research support, acted as a consultant, and/or served on a speakers
   bureau for Abbott, Addrenex, AstraZeneca, Bristol-Myers Squibb, Forest,
   GlaxoSmithKline, Johnson & Johnson, Eli Lilly & Co., Neuropharm,
   Novartis, Organon, Otsuka, Pfizer, Sanofi-aventis, Sepracore, Shire,
   Solvay, Supernus Pharmaceuticals, Validus, and Wyeth. JRC has received
   research support, acted as a consultant, and/or served on an advisory
   board for Abbott, AstraZeneca, Bristol-Myers Squibb, France Foundation,
   GlaxoSmithKline, Janssen, Johnson & Johnson, Eli Lilly & Co., Pfizer,
   Servier, and Solvay/Wyeth. PC has no relevant disclosures to report.
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NR 55
TC 149
Z9 165
U1 1
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1398-5647
EI 1399-5618
J9 BIPOLAR DISORD
JI Bipolar Disord.
PD JUN
PY 2010
VL 12
IS 4
BP 404
EP 413
DI 10.1111/j.1399-5618.2010.00823.x
PG 10
WC Clinical Neurology; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA 613YJ
UT WOS:000279020900007
PM 20636638
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Brito-Mutunayagam, R
   Appleton, SL
   Wilson, DH
   Ruffin, RE
   Adams, RJ
AF Brito-Mutunayagam, Roshan
   Appleton, Sarah L.
   Wilson, David H.
   Ruffin, Richard E.
   Adams, Robert J.
CA N W Adelaide Cohort Hlth Study
TI Global Initiative for Chronic Obstructive Lung Disease Stage 0 Is
   Associated With Excess FEV1 Decline in a Representative
   Population Sample
SO CHEST
LA English
DT Article
ID PULMONARY-DISEASE; CUMULATIVE INCIDENCE; CHRONIC-BRONCHITIS;
   YOUNG-ADULTS; COPD; MORTALITY; GENDER; HEALTH; RISK; INFORMATION
AB Background: The Global Initiative for Chronic Obstructive Lung Disease (GOLD) guideline removed stage 0 (chronic cough and sputum without airflow obstruction, GOLD-0) because of poor prognostic value. Preventative intervention may be relevant for those with chronic symptoms; therefore, we assessed the stability, morbidity, and FEV1 decline associated with GOLD stage 0 in a representative adult population cohort.
   Methods: Baseline (n = 4,060) and follow-up (n = 3,206, mean 3.5 years) clinic assessment of the North West Adelaide Health Study included postbronchoclilator spirometry, anthropometry, and measures of doctor-diagnosed asthma, respiratory symptoms, smoking status, quality of life, and depression.
   Results: Baseline GOLD-0 prevalence was 17.0% (n = 584). At follow-up (n = 420), 39.8% remained stable, 1.4% progressed to GOLD stages 1 to 2, and 58.8% resolved to no symptoms. Persistent GOLD-0 at follow-up was associated with persistent smoking (men: odds ratio [OR] = 11.9, 95% CI, 6.4-22.1; women: OR = 4.0, 95% CI, 2.1-7.4), and depressive symptoms (men: OR = 3.8, 95% CI, 1.9-7.6; women: OR = 3.2, 95% CI, 1.7-5.9), with highest quartile of FEV1 decline (mL) per year (OR = 2.1, 95% CI, 1.2-3.7) and the metabolic syndrome (OR = 1.7, 95% CI, 1.01-3.0) in men, and with older age in women. These associations generally held in smokers and never-smokers. Resolving GOLD-0 was associated with smoking cessation (OR = 13.7; 95% CI, 4.6-40.1), FEV1 decline (mL) per year below the median (OR = 2.0; 95% CI, 1.1-3.5), normal BMI, and younger age groups. Sensitivity analyses based on the presence of sputum did not change the observed associations.
   Conclusion: Persistent GOLD-0 identified people with physical and psychologic morbidity in both smokers and nonsmokers. Identification of those with persistent respiratory symptoms is therefore important. Excess FEY, decline in men suggests GOLD-0 may identify a group at risk to progress to COPD over time. CHEST 2010; 138(3):605-613
C1 [Appleton, Sarah L.; Wilson, David H.; Ruffin, Richard E.; Adams, Robert J.] Univ Adelaide, Queen Elizabeth Hosp Campus, Discipline Med, Hlth Observ, Adelaide, SA 5011, Australia.
   [Brito-Mutunayagam, Roshan] Rockhampton Base Hosp, Dept Med, Rockhampton, Qld, Australia.
C3 University of Adelaide
RP Appleton, SL (corresponding author), Univ Adelaide, Queen Elizabeth Hosp Campus, Discipline Med, Hlth Observ, Woodville Rd, Adelaide, SA 5011, Australia.
EM sarah.appleton@adelaide.edu.au
RI Adams, Robert/Z-3197-2019; Appleton, Sarah/Y-5206-2019; Appleton,
   Sarah/E-9149-2017
OI Appleton, Sarah/0000-0001-7292-9714
FU University of Adelaide; South Australian Department of Health; National
   Health and Medical Research Council; Queen Elizabeth Hospital Research
   Foundation; Australian Research Council
FX Funding/Support: This study was funded by the University of Adelaide and
   the South Australian Department of Health. Financial/nonfinancial
   disclosures: The authors have reported to CHEST the following conflicts
   of interest: Drs Ruffin, Adams, and Wilson have received grant monies
   from the National Health and Medical Research Council (2007), and Queen
   Elizabeth Hospital Research Foundation (2009). Dr Adams received grant
   money in 2009 from the Australian Research Council. Dr Ruffin has been
   an expert witness for comment about a 1988 paper on combination therapy
   GlaxoSmithKline donated 50 peak flow meters for research conducted in
   2004; Adelaide University has received honoraria for presentations
   (GlaxoSmithKline [GSK]: 2004, 2005, and 2007) and expert witness
   testimony (GSK: 2008; Mundipharma: 2009) on behalf of Dr Ruffin. Dr
   Adams has received travel grants and speakers fees from GlaxoSmithKline
   (2007-2009). Mr Brito-Mutunayagam and Ms Appleton have reported that no
   potential conflicts of interest exist with any companies/organizations
   whose products or services may be discussed in this article.
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NR 39
TC 23
Z9 25
U1 0
U2 4
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0012-3692
EI 1931-3543
J9 CHEST
JI Chest
PD SEP
PY 2010
VL 138
IS 3
BP 605
EP 613
DI 10.1378/chest.09-2607
PG 9
WC Critical Care Medicine; Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Respiratory System
GA 659IZ
UT WOS:000282561500024
PM 20418365
DA 2025-06-11
ER

PT J
AU Haug, N
   Deischinger, C
   Gyimesi, M
   Kautzky-Willer, A
   Thurner, S
   Klimek, P
AF Haug, Nils
   Deischinger, Carola
   Gyimesi, Michael
   Kautzky-Willer, Alexandra
   Thurner, Stefan
   Klimek, Peter
TI High-risk multimorbidity patterns on the road to cardiovascular
   mortality
SO BMC MEDICINE
LA English
DT Article
DE Disease trajectories; Comorbidities; Metabolic syndrome; Cardiovascular
   disease; Machine learning
ID ELECTRONIC HEALTH RECORDS; GENDER-DIFFERENCES; DIABETES-MELLITUS;
   DISEASE; COMPLICATIONS; DEPRESSION; PREVALENCE; DIAGNOSIS; SEX
AB Background Multimorbidity, the co-occurrence of two or more diseases in one patient, is a frequent phenomenon. Understanding how different diseases condition each other over the lifetime of a patient could significantly contribute to personalised prevention efforts. However, most of our current knowledge on the long-term development of the health of patients (their disease trajectories) is either confined to narrow time spans or specific (sets of) diseases. Here, we aim to identify decisive events that potentially determine the future disease progression of patients. Methods Health states of patients are described by algorithmically identified multimorbidity patterns (groups of included or excluded diseases) in a population-wide analysis of 9,000,000 patient histories of hospital diagnoses observed over 17 years. Over time, patients might acquire new diagnoses that change their health state; they describe a disease trajectory. We measure the age- and sex-specific risks for patients that they will acquire certain sets of diseases in the future depending on their current health state. Results In the present analysis, the population is described by a set of 132 different multimorbidity patterns. For elderly patients, we find 3 groups of multimorbidity patterns associated with low (yearly in-hospital mortality of 0.2-0.3%), medium (0.3-1%) and high in-hospital mortality (2-11%). We identify combinations of diseases that significantly increase the risk to reach the high-mortality health states in later life. For instance, in men (women) aged 50-59 diagnosed with diabetes and hypertension, the risk for moving into the high-mortality region within 1 year is increased by the factor of 1.96 +/- 0.11 (2.60 +/- 0.18) compared with all patients of the same age and sex, respectively, and by the factor of 2.09 +/- 0.12 (3.04 +/- 0.18) if additionally diagnosed with metabolic disorders. Conclusions Our approach can be used both to forecast future disease burdens, as well as to identify the critical events in the careers of patients which strongly determine their disease progression, therefore constituting targets for efficient prevention measures. We show that the risk for cardiovascular diseases increases significantly more in females than in males when diagnosed with diabetes, hypertension and metabolic disorders.
C1 [Haug, Nils; Thurner, Stefan; Klimek, Peter] Med Univ Vienna, CeMSIIS, Sect Sci Complex Syst, A-1090YYY Vienna, Austria.
   [Haug, Nils; Thurner, Stefan; Klimek, Peter] Complex Sci Hub Vienna, Josefstadter Str 39, A-1080 Vienna, Austria.
   [Thurner, Stefan] IIASA, Schlosspl 1, A-2361 Laxenburg, Austria.
   [Thurner, Stefan] Santa Fe Inst, 1399 Hyde Pk Rd, Santa Fe, NM 87501 USA.
   [Deischinger, Carola; Kautzky-Willer, Alexandra] Med Univ Vienna, Dept Internal Med 3, Div Endocrinol & Metab, Gender Med Unit, Spitalgasse 23, A-1090 Vienna, Austria.
   [Gyimesi, Michael] Gesundheit Osterreich GmbH, Stubenring 6, A-1010 Vienna, Austria.
C3 Medical University of Vienna; International Institute for Applied
   Systems Analysis (IIASA); The Santa Fe Institute; Medical University of
   Vienna
RP Klimek, P (corresponding author), Med Univ Vienna, CeMSIIS, Sect Sci Complex Syst, A-1090YYY Vienna, Austria.; Klimek, P (corresponding author), Complex Sci Hub Vienna, Josefstadter Str 39, A-1080 Vienna, Austria.
EM peter.klimek@meduniwien.ac.at
RI Klimek, Peter/AAC-2723-2019
OI Klimek, Peter/0000-0003-1187-6713; Haug, Nina/0000-0002-5130-9193
FU WWTF [MA16-045]; European Commission [700621]; FFG [857136]
FX This study was supported financially by the WWTF "Mathematics and..."
   Project MA16-045, European Commission, H2020 SmartResilience No. 700621
   and FFG Project 857136.
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NR 54
TC 34
Z9 36
U1 2
U2 15
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1741-7015
J9 BMC MED
JI BMC Med.
PD MAR 10
PY 2020
VL 18
IS 1
AR 44
DI 10.1186/s12916-020-1508-1
PG 12
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA KW1PL
UT WOS:000520943300001
PM 32151252
OA Green Published, Green Accepted, gold
DA 2025-06-11
ER

PT J
AU Zheng, Y
   Sun, QH
   Chen, K
   Yan, WH
   Pan, CY
   Lu, JM
   Dou, JT
   Lu, ZH
   Ba, JM
   Wang, BA
   Mu, YM
AF Zheng, Yu
   Sun, Qihong
   Chen, Kang
   Yan, Wenhua
   Pan, Changyu
   Lu, Juming
   Dou, Jingtao
   Lu, Zhaohui
   Ba, Jianming
   Wang, Baoan
   Mu, Yiming
TI Waist-to-Hip Ratio, Dyslipidemia, Glycemic Levels, Blood Pressure and
   Depressive Symptoms among Diabetic and Non-Diabetic Chinese Women: A
   Cross-Sectional Study
SO PLOS ONE
LA English
DT Article
ID BODY-MASS INDEX; METABOLIC SYNDROME; SERUM-CHOLESTEROL; BIDIRECTIONAL
   ASSOCIATION; ABDOMINAL OBESITY; MAJOR DEPRESSION; JOLLY FAT; JAPANESE;
   RISK; CIRCUMFERENCE
AB Objectives: To explore the relationship between depressive symptoms and waist-to-hip ratio, dyslipidemia, glycemic levels or blood pressure among diabetic and non-diabetic Chinese women.
   Methods: 11,908 women aged >= 40 years were enrolled in this cross-sectional study, including 2,511 with type 2 diabetes and 9,397 without. Depressive symptoms (defined as having mild-to-severe depressive symptoms) were assessed by the Patient Health Questionnaire-9 (PHQ-9) diagnostic algorithm. The prevalence and the odds ratios (ORs) with 95% confidence intervals (CIs) for having depressive symptoms were estimated using logistic regression analysis.
   Results: The age-adjusted prevalence of depressive symptoms was significantly higher in non-diabetic subjects with waist-to-hip ratio (WHR) >= 0.9 (8.6%, age-adjusted OR 1.51 [95% CI 1.17, 1.95]), total cholesterol (TC)>6.22 mmol/L (8.8%, 1.58 [1.16, 2.15]), and Hemoglobin A1c (HbA1c) >= 6.00 mmol/L (7.7%, 1.69 [1.34, 2.14]), while it was significantly lower in nondiabetic subjects with diastolic blood pressure (DBP) between 80 to 89 mmHg (6.2%, 0.78 [0.64, 0.95]). These relationships remained significant even after controlling for multiple factors (WHR >= 0.9: multivariable-adjusted OR 1.39 [95% CI 1.07, 1.80]; TC>6.22 mmol/L: 1.56 [1.14, 2.12]; HbA1c >= 6.00 mmol/L: 1.64 [1.30, 2.08]; DBP 80-89 mmHg: 0.78 [0.64, 0.95]). However, no significant trend between depressive symptoms and WHC, TC, HbA1c, DBP was observed in diabetic women, and no significant trend relationship between depressive symptoms and BMI, WC, TG, or SBP was observed in both nondiabetic and diabetic women. Moreover, the prevalence of depressive symptoms was significantly higher in previously diagnosed diabetes, compared with non-diabetic subjects, while no significant differences were observed between newly diagnosed diabetes and non-diabetic subjects.
   Conclusion: The present study showed a relationship between WHR, TC, HbA1c, DBP and depressive symptoms among non-diabetic women, while no significant relationship between them was observed among diabetic women, even after controlling for multiple confounding factors.
C1 [Zheng, Yu; Sun, Qihong; Chen, Kang; Yan, Wenhua; Pan, Changyu; Lu, Juming; Dou, Jingtao; Lu, Zhaohui; Ba, Jianming; Wang, Baoan; Mu, Yiming] Chinese Peoples Liberat Army Gen Hosp, Dept Endocrinol, Beijing, Peoples R China.
   [Zheng, Yu] Nankai Univ, Sch Med, Tianjin 300071, Peoples R China.
   [Sun, Qihong] Fushun Hosp TCM, Liaoning, Peoples R China.
C3 Chinese People's Liberation Army General Hospital; Nankai University
RP Mu, YM (corresponding author), Chinese Peoples Liberat Army Gen Hosp, Dept Endocrinol, Beijing, Peoples R China.
EM muyiming@yeah.net
RI Chen, Kang/LVS-6585-2024; lu, jm/JPK-3675-2023; wenhua,
   yan/JMB-7049-2023
FU National Science and Technology Major Project [2011ZX09307-001-08]
FX This work was supported by National Science and Technology Major Project
   (2011ZX09307-001-08). The funder had no role in study design, data
   collection and analysis, decision to publish, or preparation of the
   manuscript.
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NR 49
TC 9
Z9 10
U1 0
U2 12
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD OCT 14
PY 2014
VL 9
IS 10
AR e109765
DI 10.1371/journal.pone.0109765
PG 11
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA AR5ZW
UT WOS:000343662500071
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Lechner, K
   Heel, S
   Uhr, M
   Dose, T
   Holsboer, F
   Lucae, S
   Schaaf, L
   Fulda, S
   Kloiber, S
   Hennings, JM
AF Lechner, Katharina
   Heel, Sarah
   Uhr, Manfred
   Dose, Tatjana
   Holsboer, Florian
   Lucae, Susanne
   Schaaf, Ludwig
   Fulda, Stephany
   Kloiber, Stefan
   Hennings, Johannes M.
TI Weight-gain independent effect of mirtazapine on fasting plasma lipids
   in healthy men
SO NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
LA English
DT Article
DE Mirtazapine; Atherogenic dyslipidemia; TG/HDL-C ratio; Body weight;
   Cardiovascular risk
ID METABOLIC SYNDROME; INSULIN-RESISTANCE; GLUCOSE-TOLERANCE;
   ANTIDEPRESSANTS; DEPRESSION; ASSOCIATION; MECHANISMS; RISK
AB Treatment with mirtazapine, a widely prescribed antidepressant, has been linked to weight gain and dyslipidemia. Whether dyslipidemia occurs secondary to increased appetite due to antidepressant treatment, or due to direct pharmacological effects of mirtazapine is unknown. The aim of this analysis is to complement our previously published results of the effect of mirtazapine on metabolism and energy substrate partitioning from a proof-of-concept, open-label clinical study (ClinicalTrials. gov NCT00878540) in 12 healthy males (20-25 years). We report the effect of a seven-day administration of mirtazapine 30 mg per day on weight and lipid metabolism in healthy men under highly standardized conditions with respect to diet, physical activity and day-night-rhythm and under continuous clinical observation. After a 7-day administration of mirtazapine 30 mg, we observed a statistically significant increase in triglyceride levels (mean change + 4.4 mg/dl; 95% CI [- 11.4; 2.6]; p = 0.044) as well as TG/HDL-C ratio (mean change + 0.2; 95% CI [- 0.4; 0.1]; p = 0.019) and a decrease in HDL-cholesterol (mean change - 4.3 mg/dl; 95% CI [2.1; 6.5]; p = 0.004), LDL-cholesterol (mean change - 8.7 mg/dl; 95% CI [3.8; 13.5]; p = 0.008), total cholesterol (mean change - 12.3 mg/dl; 95% CI [5.4; 19.1]; p = 0.005), and non-HDL-C (mean change - 8.0 mg/dl; 95% CI [1.9; 14.0]; p = 0.023). Notably, weight (mean change - 0.6 kg; 95% CI [0.4; 0.8]; p = 0.002) and BMI (mean change - 0.2; 95% CI [0.1; 0.2]; p = 0.002) significantly decreased. No change in waist circumference (mean change - 0.4 cm; 95% CI [- 2.1; 2.9]; p = 0.838) or waist-to-hip-ratio (mean change 0.0; 95% CI [- 0.0; 0.0]; p = 0.814) was observed. This is the first study showing unfavorable changes in lipid metabolism under mirtazapine in healthy individuals despite highly standardized conditions including dietary restriction, and despite the observation of a decrease of weight. Our findings support the hypothesis that mirtazapine has direct pharmacological effects on lipid metabolism. ClinicalTrials. gov: NCT00878540.
C1 [Lechner, Katharina; Heel, Sarah; Uhr, Manfred; Dose, Tatjana; Holsboer, Florian; Lucae, Susanne; Fulda, Stephany; Kloiber, Stefan; Hennings, Johannes M.] Max Planck Inst Psychiat, Munich, Germany.
   [Lechner, Katharina] Tech Univ Munich, German Heart Ctr Munich, Dept Cardiol, Munich, Germany.
   [Lechner, Katharina] DZHK German Ctr Cardiovasc Res, Partner Site Munich, Munich Heart Alliance, Munich, Germany.
   [Schaaf, Ludwig] Max Planck Inst Psychiat, Clin Neuroendocrinol & Androl, Munich, Germany.
   [Fulda, Stephany] EOC, Neuroctr Southern Switzerland, Lugano, Switzerland.
   [Kloiber, Stefan] Campbell Family Mental Hlth Res Inst, Ctr Addict & Mental Hlth, Toronto, ON, Canada.
   [Kloiber, Stefan] Univ Toronto, Inst Med Sci, Dept Psychiat, Dept Pharmacol & Toxicol, Toronto, ON, Canada.
   [Hennings, Johannes M.] Kbo Isar Amper Klinikum Munchen Ost, Dept Dialect Behav Therapy, Vockestr 72, D-85540 Haar Munich, Germany.
C3 Max Planck Society; Technical University of Munich; German Heart Centre
   Munich; Munich Heart Alliance; German Centre for Cardiovascular
   Research; Max Planck Society; University of Toronto; Centre for
   Addiction & Mental Health - Canada; University of Toronto
RP Hennings, JM (corresponding author), Max Planck Inst Psychiat, Munich, Germany.; Hennings, JM (corresponding author), Kbo Isar Amper Klinikum Munchen Ost, Dept Dialect Behav Therapy, Vockestr 72, D-85540 Haar Munich, Germany.
EM Johannes.Hennings@kbo.de
RI Kloiber, Stefan/AAW-8786-2021; Fulda, Stephany/C-6867-2013
OI Lechner, Katharina/0000-0002-3582-3512
FU Projekt DEAL
FX Open Access funding enabled and organized by Projekt DEAL.
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NR 36
TC 4
Z9 4
U1 1
U2 6
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0028-1298
EI 1432-1912
J9 N-S ARCH PHARMACOL
JI Naunyn-Schmiedebergs Arch. Pharmacol.
PD SEP
PY 2023
VL 396
IS 9
BP 1999
EP 2008
DI 10.1007/s00210-023-02448-y
EA MAR 2023
PG 10
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA T6UY8
UT WOS:000945753900001
PM 36890393
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Ko, KD
   Lee, KY
   Cho, B
   Park, MS
   Son, KY
   Ha, JH
   Park, SM
AF Ko, Ki Dong
   Lee, Ka Yeon
   Cho, Belong
   Park, Min Sun
   Son, Ki Young
   Ha, Jung Hwa
   Park, Sang Min
TI Disparities in Health-Risk Behaviors, Preventive Health Care
   Utilizations, and Chronic Health Conditions for People With
   Disabilities: The Korean National Health and Nutrition Examination
   Survey
SO ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
LA English
DT Article
DE Complications; Disabled persons; Health behavior; Healthcare
   disparities; Preventive health services; Rehabilitation
ID BODY-MASS INDEX; PHYSICAL-ACTIVITY; METABOLIC SYNDROME; PUBLIC-HEALTH;
   ADULTS; WOMEN; PROGRAM; DEPRESSION; MANAGEMENT; DIAGNOSIS
AB Ko KD, Lee KY, Cho B, Park MS, Son KY, Ha JH, Park SM. Disparities in health-risk behaviors, preventive health care utilizations, and chronic health conditions for people with disabilities: the Korean National Health and Nutrition Examination Survey. Arch Phys Med Rehabil 2011;92:1230-7.
   Objective: To examine how disability status is related with health disparities in South Korea.
   Design: The study compared 3 indicators of health (health-risk behaviors, preventive health care utilizations, and chronic health conditions) according to the presence of disabilities using the Third Korean National Health and Nutrition Examination Survey, 2005 (KNHANES III).
   Setting: We obtained data from the KNHANES III, which is the third nationwide representative study using a stratified, multistage probability sampling design.
   Participants: Subjects (N=5475) aged 20 years or older were included in the study; persons with disabilities (n=218) and persons without disabilities (n=5257).
   Interventions: Not applicable.
   Main Outcome Measures: Nonconditional multiple logistic regression and adjusted mean were used to identify health disparities in health-risk behaviors, preventive health care utilizations, and chronic health conditions.
   Results: Subjects with disabilities were more likely to be physically inactive (adjusted odds ratio [AOR]=3.06; 95% confidence interval [CI], 1.71-5.48 for no physical activity; AOR=1.70; 95% CI, 1.19-2.43 for insufficient physical activity) than those without disabilities. Women aged 40 years or older with disabilities were less likely to receive cervical cancer screening services (AOR=0.52; 95% CI, 0.27-0.98). Adults with disabilities had higher proportion of osteoporosis (AOR=2.41; 95% CI, 1.50-3.88), underweight (AOR=2.14; 95% CI, 1.07-4.28), suicidal thoughts (AOR=1.86; 95% CI, 1.35-2.56), and had impaired quality of life (95% CI of adjusted mean, 60.89-65.35 compared to 69.95-70.84 in adults without disabilities).
   Conclusions: There exists substantial disability-related health disparities in South Korea. People with disabilities may be the underserved subpopulation demonstrating health disparities. The findings in this study underscore the continued needs in order to reduce health problems and disparities for people with disabilities.
C1 [Ko, Ki Dong; Cho, Belong; Park, Min Sun; Son, Ki Young; Park, Sang Min] Seoul Natl Univ, Dept Family Med, Seoul Natl Univ Hosp, Coll Med, Seoul 110744, South Korea.
   [Ha, Jung Hwa] Univ Chicago, Sch Social Serv Adm, Chicago, IL 60637 USA.
C3 Seoul National University (SNU); Seoul National University Hospital;
   University of Chicago
RP Park, SM (corresponding author), Seoul Natl Univ, Dept Family Med, Seoul Natl Univ Hosp, Coll Med, 101 Daehangno, Seoul 110744, South Korea.
EM smpark.snuh@gmail.com
RI Park, Sang/V-9194-2019; Park, Sang/J-5484-2012; Cho,
   Belong/GLU-3443-2022
OI Son, Ki Young/0000-0003-1262-100X
FU Korean Academy of Family Medicine [KAFM-10-01-1]
FX Supported by the Korean Academy of Family Medicine (research fund no.
   KAFM-10-01-1).
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U1 0
U2 20
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0003-9993
EI 1532-821X
J9 ARCH PHYS MED REHAB
JI Arch. Phys. Med. Rehabil.
PD AUG
PY 2011
VL 92
IS 8
BP 1230
EP 1237
DI 10.1016/j.apmr.2011.03.004
PG 8
WC Rehabilitation; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Rehabilitation; Sport Sciences
GA 803WL
UT WOS:000293612800006
PM 21807142
DA 2025-06-11
ER

PT J
AU Huhtaniemi, I
AF Huhtaniemi, Ilpo
TI Late-onset hypogonadism: current concepts and controversies of
   pathogenesis, diagnosis and treatment
SO ASIAN JOURNAL OF ANDROLOGY
LA English
DT Review
DE hypogonadism; male ageing; obesity; testicular function; testosterone
ID TANDEM MASS-SPECTROMETRY; TESTOSTERONE REPLACEMENT THERAPY; SYMPTOMATIC
   ANDROGEN DEFICIENCY; PITUITARY-TESTICULAR FUNCTION; BONE-MINERAL
   DENSITY; LIFE-STYLE FACTORS; MIDDLE-AGED MEN; OLDER MEN; SERUM
   TESTOSTERONE; DOUBLE-BLIND
AB Although suppressed serum testosterone (T) is common in ageing men, only a small proportion of them develop the genuine syndrome of low T associated with diffuse sexual (e. g., erectile dysfunction), physical (e. g. loss of vigor and frailty) and psychological (e. g., depression) symptoms. This syndrome carries many names, including male menopause or climacterium, andropause and partial androgen deficiency of the ageing male (PADAM). Late-onset hypogonadism (LOH) describes it best and is therefore generally preferred. The decrease of T in LOH is often marginal, and hypogonadism can be either due to primary testicular failure (low T, high luteinizing hormone (LH)) or secondary to a hypothalamic-pituitary failure (low T, low or inappropriately normal LH). The latter form is more common and it is usually associated with overweight/obesity or chronic diseases (e. g., type 2 diabetes mellitus, the metabolic syndrome, cardiovascular and chronic obstructive pulmonary disease, and frailty). A problem with the diagnosis of LOH is that often the symptoms (in 20%-40% of unselected men) and low circulating T (in 20% of men > 70 years of age) do not coincide in the same individual. The European Male Ageing Study (EMAS) has recently defined the strict diagnostic criteria for LOH to include the simultaneous presence of reproducibly low serum T (total T < 11 nmol l(-1) and free T < 220 pmol l(-1)) and three sexual symptoms (erectile dysfunction, and reduced frequency of sexual thoughts and morning erections). By these criteria, only 2% of 40- to 80-year-old men have LOH. In particular obesity, but also impaired general health, are more common causes of low T than chronological age per se. Evidence-based information whether, and how, LOH should be treated is sparse. The most logical approach is lifestyle modification, weight reduction and good treatment of comorbid diseases. T replacement is widely used for the treatment, but evidence-based information about its real benefits and short-and long-term risks, is not yet available. In this review, we will summarize the current concepts and controversies in the pathogenesis, diagnosis and treatment of LOH.
C1 [Huhtaniemi, Ilpo] Univ London Imperial Coll Sci Technol & Med, Inst Reprod & Dev Biol, London, England.
   [Huhtaniemi, Ilpo] Univ Turku, Dept Physiol, Turku, Finland.
C3 Imperial College London; University of Turku
RP Huhtaniemi, I (corresponding author), Univ London Imperial Coll Sci Technol & Med, Inst Reprod & Dev Biol, Hammersmth Campus, London, England.
EM ilpo.huhtaniemi@imperial.ac.uk
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NR 113
TC 142
Z9 167
U1 0
U2 34
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, 400059, INDIA
SN 1008-682X
EI 1745-7262
J9 ASIAN J ANDROL
JI Asian J. Androl.
PD MAR
PY 2014
VL 16
IS 2
BP 192
EP 202
DI 10.4103/1008-682X.122336
PG 11
WC Andrology; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Urology & Nephrology
GA AC7RP
UT WOS:000332729700006
PM 24407185
OA gold, Green Submitted, Green Accepted, Green Published
DA 2025-06-11
ER

PT J
AU Maalmi, H
   Herder, C
   Bönhof, GJ
   Strassburger, K
   Zaharia, OP
   Rathmann, W
   Burkart, V
   Szendroedi, J
   Roden, M
   Ziegler, D
AF Maalmi, Haifa
   Herder, Christian
   Boenhof, Gidon J.
   Strassburger, Klaus
   Zaharia, Oana-Patricia
   Rathmann, Wolfgang
   Burkart, Volker
   Szendroedi, Julia
   Roden, Michael
   Ziegler, Dan
CA GDS Grp
TI Differences in the prevalence of erectile dysfunction between novel
   subgroups of recent-onset diabetes
SO DIABETOLOGIA
LA English
DT Article
DE Diabetes subgroups; Erectile dysfunction; Inflammation; Insulin
   resistance; New-onset diabetes
ID INSULIN-RESISTANCE; METABOLIC SYNDROME; CARDIOVASCULAR-DISEASE;
   AUTONOMIC DYSFUNCTION; ENDOTHELIAL FUNCTION; SEXUAL DYSFUNCTION; MEN;
   ASSOCIATION; RISK; INFLAMMATION
AB Aims/hypothesis In men with diabetes, the prevalence of erectile dysfunction increases with advanced age and longer diabetes duration and is substantially higher in men with type 2 diabetes than those with type 1 diabetes. This study aimed to evaluate the prevalence of erectile dysfunction among the five novel subgroups of recent-onset diabetes and determine the strength of associations between diabetes subgroups and erectile dysfunction.
   Methods A total of 351 men with recent-onset diabetes (<1 year) from the German Diabetes Study baseline cohort and 124 men without diabetes were included in this cross-sectional study. Erectile dysfunction was assessed with the International Index of Erectile Function (IIEF) questionnaire. Poisson regression models were used to estimate associations between diabetes subgroups (each subgroup tested against the four other subgroups as reference) and erectile dysfunction (dependent binary variable), adjusting for variables used to define diabetes subgroups, high-sensitivity C-reactive protein and depression.
   Results The prevalence of erectile dysfunction was markedly higher in men with diabetes than in men without diabetes (23% vs 11%, p = 0.004). Among men with diabetes, the prevalence of erectile dysfunction was highest in men with severe insulin-resistant diabetes (SIRD) (52%), lowest in men with severe autoimmune diabetes (SAID) (7%), and intermediate in men with severe insulin-deficient diabetes (SIDD), mild obesity-related diabetes (MOD) and mild age-related diabetes (MARD) (31%, 18% and 29%, respectively). Men with SIRD had an adjusted RR of 1.93 (95% CI 1.04, 3.58) for prevalent erectile dysfunction (p = 0.038). Similarly, men with SIDD had an adjusted RR of 3.27 (95% CI 1.18, 9.10) (p = 0.023). In contrast, men with SAID and those with MARD had unadjusted RRs of 0.26 (95% CI 0.11, 0.58) (p = 0.001) and 1.52 (95% CI 1.04, 2.22) (p = 0.027), respectively. However, these associations did not remain statistically significant after adjustment.
   Conclusions/interpretation The high RRs for erectile dysfunction in men with recent-onset SIRD and SIDD point to both insulin resistance and insulin deficiency as major contributing factors to this complication, suggesting different mechanisms underlying erectile dysfunction in these subgroups.
C1 [Maalmi, Haifa; Herder, Christian; Boenhof, Gidon J.; Zaharia, Oana-Patricia; Burkart, Volker; Szendroedi, Julia; Roden, Michael; Ziegler, Dan] Heinrich Heine Univ Dusseldorf, German Diabet Ctr DDZ, Inst Clin Diabetol, Leibniz Ctr Diabet Res, Dusseldorf, Germany.
   [Maalmi, Haifa; Herder, Christian; Boenhof, Gidon J.; Strassburger, Klaus; Zaharia, Oana-Patricia; Rathmann, Wolfgang; Burkart, Volker; Szendroedi, Julia; Roden, Michael; Ziegler, Dan] German Ctr Diabet Res DZD, Partner Dusseldorf, Munich, Germany.
   [Herder, Christian; Boenhof, Gidon J.; Zaharia, Oana-Patricia; Szendroedi, Julia; Roden, Michael; Ziegler, Dan] Heinrich Heine Univ Dusseldorf, Med Fac, Dept Endocrinol & Diabetol, Dusseldorf, Germany.
   [Herder, Christian; Boenhof, Gidon J.; Zaharia, Oana-Patricia; Szendroedi, Julia; Roden, Michael; Ziegler, Dan] Heinrich Heine Univ Dusseldorf, Univ Hosp Dusseldorf, Dusseldorf, Germany.
   [Strassburger, Klaus; Rathmann, Wolfgang] Heinrich Heine Univ Dusseldorf, German Diabet Ctr DDZ, Inst Biometr & Epidemiol, Leibniz Ctr Diabet Res, Dusseldorf, Germany.
C3 Leibniz Association; Deutsches Diabetes-Zentrum (DDZ); Heinrich Heine
   University Dusseldorf; German Center for Diabetes Research (DZD);
   Heinrich Heine University Dusseldorf; Heinrich Heine University
   Dusseldorf; Heinrich Heine University Dusseldorf Hospital; Heinrich
   Heine University Dusseldorf; Leibniz Association; Deutsches
   Diabetes-Zentrum (DDZ)
RP Herder, C; Roden, M (corresponding author), Heinrich Heine Univ Dusseldorf, German Diabet Ctr DDZ, Inst Clin Diabetol, Leibniz Ctr Diabet Res, Dusseldorf, Germany.; Herder, C; Roden, M (corresponding author), German Ctr Diabet Res DZD, Partner Dusseldorf, Munich, Germany.; Herder, C; Roden, M (corresponding author), Heinrich Heine Univ Dusseldorf, Med Fac, Dept Endocrinol & Diabetol, Dusseldorf, Germany.; Herder, C; Roden, M (corresponding author), Heinrich Heine Univ Dusseldorf, Univ Hosp Dusseldorf, Dusseldorf, Germany.
EM christian.herder@ddz.de; michael.roden@ddz.de
RI Maalmi, Haifa/AAU-7476-2021; Roden, Michael/AAD-3843-2019; Zaharia,
   Oana/AAV-1885-2021; Qasrawi, Radwan/AAA-6245-2019
OI Buyken, Anette/0000-0002-4301-1127; Kotzka, Jorg/0000-0003-1173-9372;
   Strassburger, Klaus/0000-0002-6636-1373; Maalmi,
   Haifa/0000-0002-2910-1142; Zaharia, Oana Patricia/0000-0002-5738-9585;
   Al-Hasani, Hadi/0000-0003-2543-0130; Ziegler, Dan/0000-0001-8956-3552
FU Projekt DEAL; German Diabetes Center (DDZ) - German Federal Ministry of
   Health (Berlin, Germany); Ministry of Culture and Science of North
   Rhine-Westphalia (Dusseldorf, Germany); German Federal Ministry of
   Education and Research (Berlin, Germany)
FX Open Access funding enabled and organized by Projekt DEAL. The German
   Diabetes Study (GDS) was initiated and financed by the German Diabetes
   Center (DDZ), which is funded by the German Federal Ministry of Health
   (Berlin, Germany), the Ministry of Culture and Science of North
   Rhine-Westphalia (Dusseldorf, Germany), and grants from the German
   Federal Ministry of Education and Research (Berlin, Germany) to the
   German Center for Diabetes Research e.V. (DZD). The funders had no role
   in study design, data collection, data analysis, data interpretation or
   writing of the report.
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NR 49
TC 22
Z9 23
U1 0
U2 10
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0012-186X
EI 1432-0428
J9 DIABETOLOGIA
JI Diabetologia
PD MAR
PY 2022
VL 65
IS 3
BP 552
EP 562
DI 10.1007/s00125-021-05607-z
EA NOV 2021
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA YS2NS
UT WOS:000720704500003
PM 34800144
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Giannopapas, V
   Palaiodimou, L
   Kitsos, D
   Papagiannopoulou, G
   Stavrogianni, K
   Chasiotis, A
   Kosmidou, M
   Tzartos, JS
   Paraskevas, GP
   Bakalidou, D
   Tsivgoulis, G
   Giannopoulos, S
AF Giannopapas, Vasileios
   Palaiodimou, Lina
   Kitsos, Dimitrios
   Papagiannopoulou, Georgia
   Stavrogianni, Konstantina
   Chasiotis, Athanasios
   Kosmidou, Maria
   Tzartos, John S.
   Paraskevas, George P.
   Bakalidou, Daphne
   Tsivgoulis, Georgios
   Giannopoulos, Sotirios
TI The Prevalence of Diabetes Mellitus Type II (DMII) in the Multiple
   Sclerosis Population: A Systematic Review and Meta-Analysis
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Review
DE multiple sclerosis; diabetes mellitus II; autoimmune disorders; vascular
   comorbidity
ID PHYSICAL-DISABILITY; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   RISK-FACTORS; COMORBIDITIES; DISEASE; HYPERTENSION; RELAPSE; OBESITY;
   INJURY
AB Introduction: The interactions between Diabetes Mellitus type II (DMII) and Multiple Sclerosis (MS) lead to higher levels of fatigue, higher risk of physical disability, faster cognitive decline, and in general a lower quality of life and a higher frequency of depression compared to the general population. All of the above accelerate the disability progression of patients with MS, reduce the patients' functional capacity, and further increase their psychological and economic burden. Methods: This systematic review and meta-analysis aims to calculate the prevalence of DMII in the MS population. Following PRISMA guidelines, a thorough search of the Medline Pubmed, Cochrane Library, and Scopus databases was performed, focusing on the frequency of DMII in the MS population. Results: A total of 19 studies were included in the synthesis. The results of the main meta-analysis of random effects using R studio 3.3.0 for Windows and the Meta r package showed that the prevalence of DMII in the MS population is 5% (95% CI [0.03, 0.07], 19 studies, I-2 = 95%, p(Q) < 0.001). Additional subgroup analysis based on region showed a difference of 4.4% (I-2 = 95.2%, p(Q) < 0.001), p(subgroupdifference) = 0.003) between European and non-European participants, while demographic- and MS-specific characteristic (EDSS, Disease Duration) did not seem to affect the prevalence of DMII in the MS population (p = 0.30, p = 0.539, p = 0.19, p = 0.838). No publication bias was discovered (Egger's p test value: 0.896). Conclusions: Even though the prevalence of DMII in the MS population is lower than 10% (the reported prevalence of DMII in the general population) the interactions between the two conditions create significant challenges for MS patients, their caregivers, and physicians. DM & UIota;& UIota; should be systematically recorded in the case of MS patients to clearly delineate any potential relationship between the two conditions. Additionally, more structured studies investigating the interactions of MS and DM & UIota;& UIota; as well as the direction of the causation between those two conditions are necessary in order to gain a deeper insight into the nature of the interaction between MS and DMII.
C1 [Giannopapas, Vasileios; Palaiodimou, Lina; Kitsos, Dimitrios; Papagiannopoulou, Georgia; Stavrogianni, Konstantina; Chasiotis, Athanasios; Tzartos, John S.; Paraskevas, George P.; Tsivgoulis, Georgios; Giannopoulos, Sotirios] Natl & Kapodistrian Univ Athens, Attikon Univ Hosp, Sch Med, Dept Neurol 2, Athens 15784, Greece.
   [Giannopapas, Vasileios; Chasiotis, Athanasios; Bakalidou, Daphne] Univ West Attica, Phys Therapy Dept, Athens 12210, Greece.
   [Giannopapas, Vasileios; Chasiotis, Athanasios; Bakalidou, Daphne] Lab Neuromuscular & Cardiovasc Study Motion Laneca, Athens 12243, Greece.
   [Stavrogianni, Konstantina] Univ Ioannina, Fac Med, Dept Physiol, Ioannina 45110, Greece.
   [Kosmidou, Maria] Univ Ioannina, Fac Med, Dept Internal Med, Ioannina 45110, Greece.
C3 University Hospital Attikon; Athens Medical School; National &
   Kapodistrian University of Athens; University of West Attica; University
   of Ioannina; University of Ioannina
RP Giannopoulos, S (corresponding author), Natl & Kapodistrian Univ Athens, Attikon Univ Hosp, Sch Med, Dept Neurol 2, Athens 15784, Greece.
EM bgiannopapas@gmail.com; lina_palaiodimou@yahoo.gr;
   georgiapap22@hotmail.com; stavrogianni.k@gmail.com; thanosch1@gmail.com;
   mkosmid@uoi.gr; jtzartos@gmail.com; geoprskvs44@gmail.com;
   dafbak@otenet.gr; tsivgoulisgiorg@yahoo.gr; sgiannop@uoi.gr
RI Palaiodimou, Lina/AFT-5092-2022; Tsivgoulis, Georgios/AAD-7467-2019
OI CHASIOTIS, ATHANASIOS K./0000-0001-7496-1195; Giannopapas,
   Vasileios/0000-0001-6210-2086; Kitsos, Dimitrios/0000-0003-0722-9329;
   Giannopoulos, Sotirios/0000-0001-7443-5179; Stavrogianni,
   Konstantina/0000-0002-1221-4618; PARASKEVAS, GEORGE/0000-0002-2481-3060;
   Palaiodimou, Lina/0000-0001-7757-609X
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NR 57
TC 14
Z9 14
U1 0
U2 0
PU MDPI
PI BASEL
PA Gross-peteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD AUG
PY 2023
VL 12
IS 15
AR 4948
DI 10.3390/jcm12154948
PG 11
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA O7OK0
UT WOS:001045657600001
PM 37568348
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Amiri, M
   Raeisi-Dehkordi, H
   Steur, M
   Grisotto, G
   Rivadeneira, F
   Ikram, MK
   Kavousi, M
   Muka, T
   Voortman, T
AF Amiri, Mojgan
   Raeisi-Dehkordi, Hamidreza
   Steur, Marinka
   Grisotto, Giorgia
   Rivadeneira, Fernando
   Ikram, M. Kamran
   Kavousi, Maryam
   Muka, Taulant
   Voortman, Trudy
TI Dietary patterns derived using reduced rank regression in postmenopausal
   women and risk of mortality: A population-based study
SO MATURITAS
LA English
DT Article
DE Postmenopause; Dietary pattern; Reduced rank regression; RRR
ID CORONARY-HEART-DISEASE; BONE-MINERAL DENSITY; COGNITIVE IMPAIRMENT;
   DEPRESSIVE SYMPTOMS; CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME;
   SEX-DIFFERENCES; SLEEP QUALITY; BLOOD-LIPIDS; HEALTH
AB Objectives: The menopause transition increases the risk of chronic conditions in women. Given the crucial role of diet in health, we identified dietary patterns that explain variations in factors related to major health concerns in postmenopausal women. Also, we explored their association with all-cause and cardiovascular mortality. Study design: This study was conducted on 1814 postmenopausal women from the population-based Rotterdam Study. Main outcome measures: Dietary patterns were identified using reduced rank regression. Response variables included bone mineral density, body composition parameters, lipid profile markers, insulin resistance, systolic blood pressure, cognitive function, depression, and sleep quality. The associations with risk of mortality were assessed using Cox proportional hazard models. Results: The first dietary pattern, characterized by higher intake of vegetables, whole grains, legumes, nuts, coffee, tea, alcoholic beverages, and cheese, explained 2.95 % of the variation in responses, accounted for 12.11 % of the variation in general cognitive function captured by G-factor, 5.62 % in systolic blood pressure, and 4.13 % in bone mineral density, and was correlated with less adiposity, lower blood pressure, lipid markers, and insulin resistance. The second dietary pattern, characterized by higher intakes of processed meat, unprocessed red meat, poultry, eggs, and coffee, and lower intakes of sweets and tea, explained 1.54 % of the variation in responses, accounted for 5.45 % of variation in fat mass percentage, 3.47 % in lean mass index, and 3.29 % in bone mineral density, and was correlated with higher adiposity, insulin resistance, and lipid markers. No associations with mortality risk were identified after adjusting for confounders such as demographics, socioeconomic status, lifestyle, disease history, and medication use. Conclusions: We identified dietary patterns explaining a range of variation in health factors related to postmenopausal health. While these dietary patterns explained a large variation in some of the individual factors, their combined explained variation across multiple risk factors simultaneously was limited and no significant association with mortality risk was observed. This study provides a foundation for future research aimed at identifying optimal dietary patterns, integrating diverse health aspects, to improve health in postmenopausal populations.
C1 [Amiri, Mojgan; Ikram, M. Kamran; Kavousi, Maryam; Voortman, Trudy] Univ Med Ctr, Dept Epidemiol, Erasmus MC, Dr Molewaterplein 40, NL-3015 GD Rotterdam, Netherlands.
   [Raeisi-Dehkordi, Hamidreza] Univ Utrecht, Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands.
   [Steur, Marinka] Wageningen Univ & Res, Div Human Nutr & Hlth, Wageningen, Netherlands.
   [Grisotto, Giorgia] Univ Bern, Inst Social & Prevent Med ISPM, Bern, Switzerland.
   [Rivadeneira, Fernando] Erasmus MC, Dept Internal Med, Rotterdam, Netherlands.
   [Muka, Taulant] Epistudia, Bern, Switzerland.
   [Voortman, Trudy] Stanford Univ, Meta Res Innovat Ctr Stanford METRICS, Stanford, CA USA.
   [Ikram, M. Kamran] Univ Med Ctr, Erasmus MC, Dept Neurol, Rotterdam, Netherlands.
C3 Erasmus University Rotterdam; Erasmus MC; Utrecht University; Utrecht
   University Medical Center; Wageningen University & Research; University
   of Bern; Erasmus University Rotterdam; Erasmus MC; Stanford University;
   Erasmus University Rotterdam; Erasmus MC
RP Voortman, T (corresponding author), Univ Med Ctr, Dept Epidemiol, Erasmus MC, Dr Molewaterplein 40, NL-3015 GD Rotterdam, Netherlands.
EM Trudy.voortman@erasmusmc.nl
RI Kavousi, Maryam/F-1174-2018; Rivadeneira, Fernando/O-5385-2015;
   Voortman, Trudy/C-2963-2015
OI Voortman, Trudy/0000-0003-2830-6813
FU Nutricia Research Foundation [a2021-T2]; Swiss National Science
   Foundation [SNSF IZSTZ0_190277]
FX Mojgan Amiri has received research support for this project from
   Nutricia Research Foundation with the project number a2021-T2. Hamidreza
   Raeisi-Dehkordi has received funding for his PhD studies from the Swiss
   National Science Foundation under the "Spirit grant" (SNSF
   IZSTZ0_190277) .
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NR 82
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0378-5122
EI 1873-4111
J9 MATURITAS
JI Maturitas
PD MAY
PY 2025
VL 196
AR 108234
DI 10.1016/j.maturitas.2025.108234
EA MAR 2025
PG 8
WC Geriatrics & Gerontology; Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology; Obstetrics & Gynecology
GA 0JM8A
UT WOS:001448858900001
PM 40090127
OA hybrid
DA 2025-06-11
ER

PT J
AU Rospond, B
   Krakowska, A
   Krosniak, M
   Muszynska, B
   Opoka, W
AF Rospond, Bartlomiej
   Krakowska, Agata
   Krosniak, Miroslaw
   Muszynska, Bozena
   Opoka, Wlodzimierz
TI The influence of high-fat and high-sucrose feeding regimes on organ
   weight, body weight, and serum concentration of bioelements in rats
SO JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
LA English
DT Article
DE Obesity; High -sucrose diet; High -fat diet; Weight; Blood serum;
   Bioelements
ID OBESITY; ZINC; INFLAMMATION; DEPRESSION
AB Background: Obesity is one of the most common diseases of civilization, and approximately 13 % of the world's adult population is obese. Obesity is defined as excessive accumulation of fat in the human body, which leads to adverse health effects such as metabolic syndrome, type 2 diabetes, and fatty liver disease (e.g., nonalcoholic liver disease). The development of obesity is accompanied by changes in the levels of certain bioelements such as copper and zinc. These elements may have an influence on the proper functioning of the central nervous system. Method: Fifty-six male Wistar rats (initial weight 290-300 g) were divided into seven experimental groups. They were fed with different feeding patterns (constant versus intermittent-binge access) and exposed to different diets (high sucrose versus high fat) to analyze the factors that affect the organ weight gain (pancreas, spleen, liver, testes, and kidneys) and total body weight gain. Further, zinc and copper levels in the serum of the animals were determined. The relationship between organ and body weight and serum metal concentration was analyzed by cluster and principal component analyses. Results: Rats with unlimited access to high fat diet (HF) and restricted intake of high sugar diet (for 2-hours daily-HSB and every second day-IHSB) have elevated body weight in comparison to the control. However, the heaviest organ weights were recorded in the HSB rats compared to the control group (pancreas, 14 %; spleen, 9 %; kidneys, 5 %; and liver, 3 %). On the other hand, an average 20 % decrease in zinc concentration was observed in rats fed with high-fat diet compared to the control. Moreover, an 18 % decrease in copper levels was observed in rats that had periodic access to high-fat diet every 2 h daily and for 2 h every other day compared to the control. Conclusion: Both the high-sucrose and high-fat diets had an influence on body and organ weights. This study demonstrates an association between the different types of diet and the parameters investigated (body and organ weights and concentration of serum bioelements).
C1 [Rospond, Bartlomiej; Krakowska, Agata; Opoka, Wlodzimierz] Jagiellonian Univ, Med Coll, Fac Pharm, Dept Inorgan & Analyt Chem, Med 9, PL-30688 Krakow, Poland.
   [Krosniak, Miroslaw] Jagiellonian Univ, Med Coll, Fac Pharm, Dept Food Chem & Nutr, Med 9, PL-30688 Krakow, Poland.
   [Muszynska, Bozena] Jagiellonian Univ, Med Coll, Fac Pharm, Dept Pharmaceut Bot, Med 9, PL-30688 Krakow, Poland.
C3 Jagiellonian University; Collegium Medicum Jagiellonian University;
   Jagiellonian University; Collegium Medicum Jagiellonian University;
   Jagiellonian University; Collegium Medicum Jagiellonian University
RP Krakowska, A (corresponding author), Jagiellonian Univ, Med Coll, Fac Pharm, Dept Inorgan & Analyt Chem, Med 9, PL-30688 Krakow, Poland.
EM agata.krakowska@uj.edu.pl
FU Statutory funds of the Jagiellonian University [K/ZDS/004127];
   Ma?opolska Centre for Entrepreneurship (MCP) [ZS.4112-129/12]
FX Statutoryfunds of the Jagiellonian University (K/ZDS/004127) and
   Malopolska Centre for Entrepreneurship (MCP) (ZS.4112-129/12).
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NR 39
TC 4
Z9 4
U1 2
U2 11
PU ELSEVIER GMBH
PI MUNICH
PA HACKERBRUCKE 6, 80335 MUNICH, GERMANY
SN 0946-672X
EI 1878-3252
J9 J TRACE ELEM MED BIO
JI J. Trace Elem. Med. Biol.
PD SEP
PY 2022
VL 73
AR 127020
DI 10.1016/j.jtemb.2022.127020
EA JUN 2022
PG 6
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 3A1LJ
UT WOS:000827025600006
PM 35780652
DA 2025-06-11
ER

PT J
AU Merz, CNB
   Pepine, CJ
   Shimokawa, H
   Berry, C
AF Merz, C. Noel Bairey
   Pepine, Carl J.
   Shimokawa, Hiroki
   Berry, Colin
TI Treatment of coronarymicrovascular dysfunction
SO CARDIOVASCULAR RESEARCH
LA English
DT Review
DE INOCA; CMD; Women; Angina; Ischaemia
ID CORONARY-ARTERY-DISEASE; CONVERTING ENZYME-INHIBITION;
   PLACEBO-CONTROLLED TRIAL; LEFT-VENTRICULAR FUNCTION; STABLE
   ANGINA-PECTORIS; CARDIAC SYNDROME-X; I-F INHIBITOR; DOUBLE-BLIND;
   MICROVASCULAR DYSFUNCTION; CHEST-PAIN
AB Contemporary data indicate that patients with signs and symptoms of ischaemia and non-obstructive coronary artery disease (INOCA) often have coronary microvascular dysfunction (CMD) with elevated risk for adverse outcomes. Coronary endothelial (constriction with acetylcholine) and/or microvascular (limited coronary flow reserve with adenosine) dysfunction are well-documented, and extensive non-obstructive atherosclerosis is often present. Despite these data, patients with INOCA currently remain under-treated, in part, because existing management guidelines do not address this large, mostly female population due to the absence of evidence-based data. Relatively small sample-sized, short-term pilot studies of symptomatic mostly women, with INOCA, using intense medical therapies targeting endothelial, microvascular, and/or atherosclerosis mechanisms suggest symptom, ischaemia, and coronary vascular functional improvement, however, randomized, controlled outcome trials testing treatment strategies have not been completed. We review evidence regarding CMD pharmacotherapy. Potent statins in combination with angiotensin-converting enzyme inhibitor (ACE-I) or receptor blockers if intolerant, at maximally tolerated doses appear to improve angina, stress testing, myocardial perfusion, coronary endothelial function, and microvascular function. The Coronary Microvascular Angina trial supports invasive diagnostic testing with stratified therapy as an approach to improve symptoms and quality of life. The WARRIOR trial is testing intense medical therapy of high-intensity statin, maximally tolerated ACE-I plus aspirin on longer-term outcomes to provide evidence for guidelines. Novel treatments and those under development appear promising as the basis for future trial planning.
C1 [Merz, C. Noel Bairey] Cedars Sinai, Barbra Streisand Womens Heart Ctr, Smidt Heart Inst, 127 S San Vicente Blvd,Suite A3600, Los Angeles, CA 90048 USA.
   [Pepine, Carl J.] Univ Florida, Div Cardiovasc Med, 1329 SW 16th St,POB 100288, Gainesville, FL 32610 USA.
   [Shimokawa, Hiroki] Tohoku Univ, Div Cardiovasc Med, Grad Sch Med, Aoba Ku, 2-1 Seiryo Machi, Sendai, Miyagi 9808575, Japan.
   [Berry, Colin] Univ Glasgow, Inst Cardiovasc & Med Sci, Glasgow G12 8QQ, Lanark, Scotland.
C3 Cedars Sinai Medical Center; State University System of Florida;
   University of Florida; Tohoku University; University of Glasgow
RP Merz, CNB (corresponding author), Cedars Sinai, Barbra Streisand Womens Heart Ctr, Smidt Heart Inst, 127 S San Vicente Blvd,Suite A3600, Los Angeles, CA 90048 USA.
EM noel.baireymerz@cshs.org
RI Berry, Colin/AAF-5268-2020
OI Pepine, Carl/0000-0002-6011-681X; Shimokawa,
   Hiroaki/0000-0001-7534-4826; Berry, Colin/0000-0002-4547-8636
FU Gilead Sciences; National Heart, Lung and Blood Institutes
   [N01-HV-68161, N01-HV-68162, N01-HV-68163, N01-HV-68164, U0164829, U01
   HL649141, U01 HL649241, K23HL105787, T32HL69751, R01 HL090957,
   1R03AG032631, HL087366, HL132448, HL033610]; National Institute on
   Aging, GCRC [MO1-RR00425]; National Center for Research Resources;
   National Center for Advancing Translational Sciences [UL1TR000124];
   Edythe L. Broad and the Constance Austin Women's Heart Research
   Fellowships, Cedars-Sinai Medical Center, Los Angeles, California;
   Gatorade Trust; National Center for Advancing Translational
   Sciences-University of Florida Clinical and Translational Science
   [UL1TR001427]; PCORnet-OneFlorida Clinical Research Consortium
   [CDRN-1501-26692]; US Dept. of Defense [PR161603]; Japan Society for
   Promotion of Science (JSPS); British Heart Foundation [PG/17/2532884,
   RE/18/6134217]; Medical Research Council [MR/S005714/1]; Japan Heart
   Foundation; Barbra Streisand Women's Cardiovascular Research and
   Education Program, Cedars-Sinai Medical Center, Los Angeles; Erika
   GlazerWomen's Heart Health Project, and the Adelson Family Foundation,
   Cedars-Sinai Medical Center, Los Angeles, California
FX This work was supported by an unrestricted research grant from Gilead
   Sciences, and contracts from the National Heart, Lung and Blood
   Institutes (nos. N01-HV-68161, N01-HV-68162, N01-HV-68163, N01-HV-68164,
   grants U0164829, U01 HL649141, U01 HL649241, K23HL105787, T32HL69751,
   R01 HL090957, 1R03AG032631), the National Institute on Aging, GCRC
   (MO1-RR00425), the National Center for Research Resources, the National
   Center for Advancing Translational Sciences (UL1TR000124), the Edythe L.
   Broad and the Constance Austin Women's Heart Research Fellowships,
   Cedars-Sinai Medical Center, Los Angeles, California, the Barbra
   Streisand Women's Cardiovascular Research and Education Program,
   Cedars-Sinai Medical Center, Los Angeles, the Erika GlazerWomen's Heart
   Health Project, and the Adelson Family Foundation, Cedars-Sinai Medical
   Center, Los Angeles, California. C. J. P. receives support from National
   Heart, Lung and Blood Institutes through grantsHL087366 (University of
   Florida Regional Clinical Center for the Cardiovascular Cell Therapy
   Research Network), HL132448 (Brain-Gut Microbiome-Immune Axis in
   Hypertension), and HL033610 (Angiotensin and Neuroimmune Activation in
   Hypertension); the Gatorade Trust through funds distributed by the
   University of Florida, Department of Medicine; National Center for
   Advancing Translational Sciences-University of Florida Clinical and
   Translational Science UL1TR001427; PCORnet-OneFlorida Clinical Research
   Consortium CDRN-1501-26692; and US Dept. of Defense PR161603 (WARRIOR).
   H.S. is supported by the Japan Heart Foundation, the Japan Society for
   Promotion of Science (JSPS). C.B. acknowledges research support from the
   British Heart Foundation (PG/17/2532884; RE/18/6134217) andMedical
   Research Council (MR/S005714/1).
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NR 134
TC 131
Z9 138
U1 0
U2 28
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0008-6363
EI 1755-3245
J9 CARDIOVASC RES
JI Cardiovasc. Res.
PD MAR 15
PY 2020
VL 116
IS 4
BP 856
EP 870
DI 10.1093/cvr/cvaa006
PG 15
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA LJ0MI
UT WOS:000529868100010
PM 32087007
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Chavushyan, VA
   Simonyan, KV
   Simonyan, RM
   Isoyan, AS
   Simonyan, GM
   Babakhanyan, MA
   Hovhannisyian, LE
   Nahapetyan, KH
   Avetisyan, LG
   Simonyan, MA
AF Chavushyan, V. A.
   Simonyan, K. V.
   Simonyan, R. M.
   Isoyan, A. S.
   Simonyan, G. M.
   Babakhanyan, M. A.
   Hovhannisyian, L. E.
   Nahapetyan, Kh. H.
   Avetisyan, L. G.
   Simonyan, M. A.
TI Effects of stevia on synaptic plasticity and NADPH oxidase level of CNS
   in conditions of metabolic disorders caused by fructose
SO BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Article
DE Neuronal plasticity; Neuronal NADPH oxidase; Dietary fructose; Stevia
ID INDUCED INSULIN-RESISTANCE; DIABETES-MELLITUS; VISCERAL ADIPOSITY;
   SILENT SYNAPSES; RISK; EXPRESSION; GLUCOSE; CONSUMPTION; DYSFUNCTION;
   SENSITIVITY
AB Background: Excess dietary fructose intake associated with metabolic syndrome and insulin resistance and increased risk of developing type 2 diabetes. Previous animal studies have reported that diabetic animals have significantly impaired behavioural and cognitive functions, pathological synaptic function and impaired expression of glutamate receptors. Correction of the antioxidant status of laboratory rodents largely prevents the development of fructose-induced plurimetabolic changes in the nervous system. We suggest a novel concept of efficiency of Stevia leaves for treatment of central diabetic neuropathy.
   Methods: By in vivo extracellular studies induced spike activity of hippocampal neurons during high frequency stimulation of entorhinal cortex, as well as neurons of basolateral amygdala to high-frequency stimulation of the hippocampus effects of Stevia rebaudiana Bertoni plant evaluated in synaptic activity in the brain of fructose-enriched diet rats. In the conditions of metabolic disorders caused by fructose, antioxidant activity of Stevia rebaudiana was assessed by measuring the NOX activity of the hippocampus, amygdala and spinal cord.
   Results: In this study, the characteristic features of the metabolic effects of dietary fructose on synaptic plasticity in hippocampal neurons and basolateral amygdala and the state of the NADPH oxidase (NOX) oxidative system of these brain formations are revealed, as well as the prospects for development of multitarget and polyfunctional phytopreparations (with adaptogenic, antioxidant, antidiabetic, nootropic activity) from native raw material of Stevia rebaudiana. Stevia modulates degree of expressiveness of potentiation/depression (approaches but fails to achieve the norm) by shifting the percentage balance in favor of depressor type of responses during high-frequency stimulation, indicating its adaptogenic role in plasticity of neural networks. Under the action of fructose an increase (3-5 times) in specific quantity of total fraction of NOX isoforms isolated from the central nervous system tissue (amygdala, hippocampus, spinal cord) was revealed. Stevia exhibits an antistress, membrane-stabilizing role reducing the level of total fractions of NOX isoforms from central nervous system tissues and regulates NADPH-dependent O-2(-) producing activity.
   Conclusion: Generally, in condition of metabolic disorders caused by intensive consumption of dietary fructose Stevia leaves contributes to the control of neuronal synaptic plasticity possibly influencing the conjugated NOX-specific targets.
C1 [Chavushyan, V. A.; Simonyan, K. V.; Isoyan, A. S.; Nahapetyan, Kh. H.; Avetisyan, L. G.] Orbeli Inst Physiol NAS RA, 22 Orbeli Bros St, Yerevan 0028, Armenia.
   [Simonyan, R. M.; Simonyan, G. M.; Simonyan, M. A.] H Buniatian Inst Biochem NAS RA, 5-1 P Sevag Str, Yerevan 0014, Armenia.
   [Babakhanyan, M. A.; Hovhannisyian, L. E.] Sci Ctr Artsakh, 8 Tigran Mets Str, Stepanakert, Nagorno Karabak, Armenia.
C3 National Academy of Sciences of Armenia; Institute of Physiology after
   L.A. Orbeli - NAS RA; Institute of Biochemistry after H. Buniatyan - NAS
   RA
RP Simonyan, KV (corresponding author), Orbeli Inst Physiol NAS RA, 22 Orbeli Bros St, Yerevan 0028, Armenia.
EM karensimonyan86@gmail.com
RI Avetisyan, Lyudmila/JTT-5747-2023; Simonyan, Karen/GXA-2514-2022
OI Hovhannisyan, Lusya/0000-0002-1572-1180
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NR 87
TC 18
Z9 19
U1 1
U2 9
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1472-6882
J9 BMC COMPLEM ALTERN M
JI BMC Complement. Altern. Med.
PD DEC 19
PY 2017
VL 17
AR 540
DI 10.1186/s12906-017-2049-9
PG 13
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA FQ9LY
UT WOS:000418684900002
PM 29258552
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Schumacher, O
   Luo, H
   Taaffe, DR
   Galvao, DA
   Tang, CL
   Chee, R
   Spry, N
   Newton, RU
AF Schumacher, Oliver
   Luo, Hao
   Taaffe, Dennis R.
   Galvao, Daniel A.
   Tang, Colin
   Chee, Raphael
   Spry, Nigel
   Newton, Robert U.
TI Effects of Exercise During Radiation Therapy on Physical Function and
   Treatment-Related Side Effects in Men With Prostate Cancer: A Systematic
   Review and Meta-Analysis
SO INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
LA English
DT Review
ID QUALITY-OF-LIFE; RANDOMIZED CONTROLLED-TRIAL; EXTERNAL-BEAM
   RADIOTHERAPY; AEROBIC EXERCISE; ANDROGEN SUPPRESSION; METABOLIC
   SYNDROME; PEDRO SCALE; FATIGUE; OUTCOMES; PREVENTION
AB Purpose: Radiation therapy is a commonly used treatment for prostate cancer; however, the side effects may negatively affect quality of life and cause patients to be less physically active. Although exercise has been shown to mitigate radiation therapy-related fatigue in men with prostate cancer during radiation therapy, other adverse effects of treatment such as physical deconditioning, urinary symptoms, or sexual dysfunction have not been systematically reviewed in this patient population. Thus, the purpose of this review was to investigate the effect of exercise on physical function and treatment-related side effects in men with prostate cancer undergoing radiation therapy.
   Methods: A systematic literature search was conducted in the PubMed, Embase, CINAHL Plus, SPORTDiscus, and Web of Science databases in December 2020. Included studies were randomized controlled trials examining the effects of aerobic and/or resistance exercise interventions on measures of physical function and treatment-related side effects in prostate cancer patients undergoing radiation therapy. Meta-analysis was performed on outcomes that were reported in 2 or more studies.
   Results: Seven publications from 6 randomized controlled trials involving 391 prostate cancer patients were included. Patients had stage Ito IV cancer with a Gleason score of <= 6 to 10. Exercise resulted in consistent significant benefits for physical function in terms of cardiovascular fitness (standardized mean difference [SMD], 0.83; 95% confidence interval [CI], 0.31-1.36; P < .01) and muscle function (SMD, 1.30; 95% CI, 0.53-2.07; P < .01). Furthermore, there was a significant positive effect of exercise on urinary toxicity (SMD, -0.71; 95% CI, -1.25 to -0.18; P < .01), but not on intestinal (P = .21) or hormonal toxicity (P = .41), depression (P = .45), or sleep symptoms (P = .88).
   Conclusion: Based on the current evidence, exercise in men with prostate cancer undergoing radiation therapy improves physical function and mitigates urinary toxicity. The effect of exercise on other treatment-related side effects are less clear and require further investigation. (C) 2021 The Author(s). Published by Elsevier Inc.
C1 [Schumacher, Oliver; Luo, Hao; Taaffe, Dennis R.; Galvao, Daniel A.; Tang, Colin; Chee, Raphael; Spry, Nigel; Newton, Robert U.] Exercise Med Res Inst, Joondalup, WA, Australia.
   [Schumacher, Oliver; Luo, Hao; Taaffe, Dennis R.; Galvao, Daniel A.; Newton, Robert U.] Edith Cowan Univ, Sch Med & Hlth Sci, Joondalup, WA, Australia.
   [Tang, Colin] Sir Charles Gairdner Hosp, Dept Radiat Oncol, Nedlands, WA, Australia.
   [Chee, Raphael] GenesisCare, Joondalup, WA, Australia.
   [Spry, Nigel] Univ Western Australia, Fac Med, Nedlands, WA, Australia.
C3 Edith Cowan University; Sir Charles Gairdner Hospital; University of
   Western Australia; University of Western Australia
RP Schumacher, O (corresponding author), Exercise Med Res Inst, Joondalup, WA, Australia.; Schumacher, O (corresponding author), Edith Cowan Univ, Sch Med & Hlth Sci, Joondalup, WA, Australia.
EM o.schumacher@ecu.edu.au
RI Schumacher, Oliver/CAG-9815-2022; LUO, HAO/AAF-7140-2021; Galvao, Daniel
   A/A-2744-2010; Newton, Robert/A-3466-2009
OI Galvao, Daniel A/0000-0002-8209-2281; Taaffe,
   Dennis/0000-0001-6381-1597; Schumacher, Oliver/0000-0002-8814-9429;
   Newton, Robert/0000-0003-0302-6129; Tang, Colin/0000-0002-4643-0466;
   LUO, Hao/0000-0001-5181-7529; Spry, Nigel/0000-0001-8659-5065
FU National Health and Medical Research Council (NHMRC) Centre of Research
   Excellence in Prostate Cancer Survivorship
FX O.S. is supported by a PhD scholarship from the National Health and
   Medical Research Council (NHMRC) Centre of Research Excellence in
   Prostate Cancer Survivorship.
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NR 62
TC 25
Z9 26
U1 1
U2 5
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0360-3016
EI 1879-355X
J9 INT J RADIAT ONCOL
JI Int. J. Radiat. Oncol. Biol. Phys.
PD NOV 1
PY 2021
VL 111
IS 3
BP 716
EP 731
DI 10.1016/j.ijrobp.2021.06.034
EA SEP 2021
PG 16
WC Oncology; Radiology, Nuclear Medicine & Medical Imaging
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Radiology, Nuclear Medicine & Medical Imaging
GA WA4AA
UT WOS:000702828400018
PM 34246737
OA hybrid
DA 2025-06-11
ER

PT J
AU Younossi, ZM
   Stepanova, M
   Henry, L
   Racila, A
   Lam, B
   Pham, HT
   Hunt, S
AF Younossi, Zobair M.
   Stepanova, Maria
   Henry, Linda
   Racila, Andrei
   Lam, Brian
   Pham, Huong T.
   Hunt, Sharon
TI A disease-specific quality of life instrument for non-alcoholic fatty
   liver disease and non-alcoholic steatohepatitis: CLDQ-NAFLD
SO LIVER INTERNATIONAL
LA English
DT Article
DE non-alcoholic fatty liver disease; non-alcoholic steatohepatitis;
   patient-reported outcome; quality of life
ID APOLIPOPROTEIN-B; APO-B; METABOLIC SYNDROME; CARDIOVASCULAR-DISEASE;
   INSULIN-RESISTANCE; HEPATIC STEATOSIS; DIAGNOSTIC-VALUE; RISK;
   ASSOCIATION; POPULATION
AB Background: Non-alcoholic fatty liver disease and non-alcoholic steatohepatitis are the most common causes of chronic liver disease with known negative impact on patients' health-related quality of life. Our aim was to validate a disease-specific health-related quality of life instrument useful for efficacy trials involving patients with non-alcoholic fatty liver disease and non-alcoholic steatohepatitis.
   Methods: From a long item selection questionnaire, we selected relevant items which, by factor analysis, were grouped into domains constituting Chronic Liver Disease Questionnaire-Non-Alcoholic Fatty Liver Disease version. The developed instrument was subjected to internal validity, test-retest reliability and construct validity assessment using standard methods.
   Results: For development of the Chronic Liver Disease Questionnaire-Non-Alcoholic Fatty Liver Disease version instrument, a 75-item-long item selection questionnaire was administered to 25 patients with non-alcoholic fatty liver disease. After item reduction, factor analysis found that 98.7% of variance in the remaining items would be explained by six factors. Thus, the resulting Chronic Liver Disease QuestionnaireNon-Alcoholic Fatty Liver Disease version instrument had 36 items grouped into six domains: Abdominal Symptoms, Activity, Emotional, Fatigue, Systemic Symptoms, and Worry. The independent validation group included another 104 patients with non-alcoholic fatty liver disease. The Cronbach's alphas of 0.74-0.90 suggested good to excellent internal consistency of the domains. Furthermore, the presence of obesity and history of depression were discriminated best by Chronic Liver Disease Questionnaire-Non-Alcoholic Fatty Liver Disease version scores ( P< .05). The domains' correlations with the most relevant domains of Short Form-36 exceeded 0.70. Test-retest reliability in a subgroup of patients (N= 27) demonstrated no significant within-patient variability with multiple administrations (all median differences were zero, all P>.15, intraclass correlations .76-.88).
   Conclusion: The Chronic Liver Disease Questionnaire-Non-Alcoholic Fatty Liver Disease version is a disease-specific health-related quality of life instrument developed and validated using an established methodology and useful for clinical trials of non-alcoholic fatty liver disease.
C1 [Younossi, Zobair M.; Racila, Andrei; Lam, Brian; Pham, Huong T.] Inova Fairfax Hosp, Dept Med, Ctr Liver Dis, Falls Church, VA USA.
   [Younossi, Zobair M.] Inova Hlth Syst, Betty & Guy Beatty Ctr Integrated Res, Falls Church, VA USA.
   [Younossi, Zobair M.; Stepanova, Maria; Henry, Linda; Racila, Andrei; Hunt, Sharon] Ctr Outcomes Res Liver Dis, Washington, DC USA.
C3 Inova Fairfax Hospital; Inova Health System
RP Younossi, ZM (corresponding author), Betty & Guy Beatty Ctr Integrated Res, Claude Moore Hlth Educ & Res Bldg, Falls Church, VA 22042 USA.
EM Zobair.younossi@inova.org
RI Younossi, Zobair M./JRY-9916-2023; Pham, Huong/KDP-2280-2024; Stepanova,
   Maria/V-5513-2019
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NR 40
TC 84
Z9 86
U1 1
U2 25
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1478-3223
EI 1478-3231
J9 LIVER INT
JI Liver Int.
PD AUG
PY 2017
VL 37
IS 8
BP 1209
EP 1218
DI 10.1111/liv.13391
PG 10
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA FA6SW
UT WOS:000405575400016
PM 28211165
DA 2025-06-11
ER

PT J
AU Chedraui, P
   Blümel, JE
   Baron, G
   Belzares, E
   Bencosme, A
   Calle, A
   Danckers, L
   Espinoza, MT
   Flores, D
   Gomez, G
   Hernandez-Bueno, JA
   Izaguirre, H
   Leon-Leon, P
   Lima, S
   Mezones-Holguin, E
   Monterrosa, A
   Mostajo, D
   Navarro, D
   Ojeda, E
   Onatra, W
   Royer, M
   Soto, E
   Tserotas, K
AF Chedraui, Peter
   Blumel, Juan E.
   Baron, German
   Belzares, Emma
   Bencosme, Ascanio
   Calle, Andres
   Danckers, Luis
   Espinoza, Maria T.
   Flores, Daniel
   Gomez, Gustavo
   Hernandez-Bueno, Jose A.
   Izaguirre, Humberto
   Leon-Leon, Patricia
   Lima, Selva
   Mezones-Holguin, Edward
   Monterrosa, Alvaro
   Mostajo, Desire
   Navarro, Daysi
   Ojeda, Eliana
   Onatra, William
   Royer, Monique
   Soto, Edwin
   Tserotas, Konstantinos
CA Collaborative Grp Res Climacteric
TI Impaired quality of life among middle aged women: A multicentre Latin
   American study
SO MATURITAS
LA English
DT Article
DE Menopause; Quality of life; Menopause rating scale; Latin America
ID MENOPAUSAL SYMPTOMS; HIGH-ALTITUDE; CLIMACTERIC SYMPTOMS; HOT FLASHES;
   POSTMENOPAUSAL WOMEN; METABOLIC SYNDROME; MENTAL-HEALTH; RISK-FACTORS;
   BODY-MASS; POPULATION
AB Background: Several studies indicate that quality of life (QoL) is impaired in middle aged women. Assessment of QoL using a single validated tool in Latin American climacteric women has not been reported to date at large scale.
   Objective: The Menopause Rating Scale (MRS) was used to assess QoL among middle aged Latin American women and determine factors associated with severe menopausal symptoms (QoL impairment).
   Methods: In this cross-sectional study, 8373 healthy women aged 40-59 years, accompanying patients to healthcare centres in 18 cities of 12 Latin American countries, were asked to fill out the MRS and a questionnaire containing socio-demographic, female and partner data.
   Results: Mean age of the entire sample was 49.1 +/- 5.7 years (median 49), a 62.5% had 12 or less years of schooling, 48.8% were postmenopausal and 14.7% were on hormonal therapy (HT). Mean total MRS score (n=8373) was 11.3 +/- 8.5 (median 10); for the somatic subscale, 4.1 +/- 3.4; the psychological subscale, 4.6 +/- 3.8 and the urogenital subscale, 2.5 +/- 2.7. The prevalence of women presenting moderate to severe total MRS scorings was high (>50%) in all countries, Chile and Uruguay being the ones with the highest percentages (80.8% and 67.4%, respectively). Logistic regression determined that impaired QoL (severe total MRS score >= 17) was associated with the use of alternatives therapies for menopause (OR: 1.47, 95% CI [1.22-1.76], p=0.0001), the use of psychiatric drugs (OR: 1.57, 95% CI [1.29-1.90], p=0.0001), attending a psychiatrist (OR: 1.66,95% CI [1.41-1.96], p=0.0001), being postmenopausal (OR: 1.48, 95% CI[1.29-1.69, p=0.0001]), having 49 years or more (OR: 1.24, 95% CI [1.08-1.42], p=0.001), living at high altitude (OR: 1.43, 95% CI [1.25-1.62, p=0.0001]) and having a partner with erectile dysfunction (OR: 1.69, 95% CI [1.47-1.94, p=0.0001]) or premature ejaculation (OR: 1.34, 95% CI [1.16-1.55, p=0.0001]). Lower risk for impaired QoL was related to living in a country with a lower income (OR: 0.77, 95% CI [0.68-0.88], p=0.0002), using HT (OR: 0.65, 95% CI [0.56-0.76], p=0.0001) and engaging in healthy habits (OR: 0.59, 95% CI[0.50-0.69], p=0.0001).
   Conclusion: To the best of our knowledge this is the first and largest study assessing QoL in a Latin American climacteric series with a high prevalence of impairment related to individual female and male characteristics and the demography of the studied population. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
C1 [Chedraui, Peter] Inst Para Salud Mujer, Guayaquil, Ecuador.
RP Chedraui, P (corresponding author), Inst Para Salud Mujer, Velez 616 & Garcia Aviles,POB 09-02000-70-A, Guayaquil, Ecuador.
EM institutochedraui@gmail.com
RI Mezones-Holguin, Edward/AAJ-2663-2020; Blümel, Juan
   Enrique/JUV-6950-2023
OI OJEDA LAZO, ELIANA JANETTE/0000-0001-6606-3029; Mezones-Holguin,
   Edward/0000-0001-7168-8613
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NR 63
TC 99
Z9 109
U1 0
U2 15
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0378-5122
EI 1873-4111
J9 MATURITAS
JI Maturitas
PD DEC 20
PY 2008
VL 61
IS 4
BP 323
EP 329
DI 10.1016/j.maturitas.2008.09.026
PG 7
WC Geriatrics & Gerontology; Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Obstetrics & Gynecology
GA 399OV
UT WOS:000262810100006
PM 19010618
DA 2025-06-11
ER

PT J
AU Goldstein, BI
   Liu, SM
   Schaffer, A
   Sala, R
   Blanco, C
AF Goldstein, Benjamin I.
   Liu, Shang-Min
   Schaffer, Ayal
   Sala, Regina
   Blanco, Carlos
TI Obesity and the three-year longitudinal course of bipolar disorder
SO BIPOLAR DISORDERS
LA English
DT Article
DE bipolar disorder; epidemiologic; longitudinal; obesity
ID NATIONAL EPIDEMIOLOGIC SURVEY; WEEKLY SYMPTOMATIC STATUS; BODY-MASS
   INDEX; I-DISORDER; METABOLIC SYNDROME; SUICIDE ATTEMPTS;
   NATURAL-HISTORY; UNITED-STATES; WEIGHT-GAIN; PREVALENCE
AB Goldstein BI, Liu S-Min, Schaffer A, Sala R, Blanco C. Obesity and the three-year longitudinal course of bipolar disorder. Bipolar Disord 2013: 00: 000000. (c) 2013 John Wiley & Sons A/S.Published by Blackwell Publishing Ltd. Objectives: Despite substantial cross-sectional evidence that obesity is associated with an increased medical and psychiatric burden in bipolar disorder (BD), few longitudinal studies have examined this topic. Methods: Subjects with BD (n=1600) who completed both Wave 1 and Wave 2 of the National Epidemiologic Survey on Alcohol and Related Conditions were included. Analyses examined the association between obesity at Wave 1, and the subsequent course of BD, and of psychiatric and medical comorbidities, between Wave 1 and Wave 2. Results: BD subjects with obesity (n=506; 29.43%), compared to BD subjects without obesity (n=1094; 70.57%) were significantly more likely to have a major depressive episode and to receive counseling for depression during follow-up, more likely to report a lifetime suicide attempt, and less likely to develop new-onset alcohol use disorders. These differences were no longer significant, however, after controlling for baseline demographic variables. No significant differences in new episodes or treatment of mania/hypomania were observed. After controlling for demographic variables, obese subjects remained significantly more likely to report any new-onset medical condition [odds ratio (OR) = 2.32, 95% confidence interval (CI): 1.633.30], new-onset hypertension (OR = 1.81, 95% CI: 1.162.82) and arthritis (OR = 1.64, 95% CI: 1.072.52). Obese subjects were significantly more likely to report physician-diagnosed diabetes (OR = 6.98, 95% CI: 4.2711.40) and hyperlipidemia (OR = 2.32, 95% CI: 1.633.30) (assessed in Wave 2 only). The incidence of heart attacks was doubled among obese subjects, although this difference was not statistically significant. Conclusions: The association between obesity and increased prospective depressive burden appears to be explained by baseline demographic variables. By contrast, obesity independently predicts the accumulation of medical conditions among adults with BD. Treatment of obesity could potentially mitigate the psychiatric and medical burden of BD.
C1 [Goldstein, Benjamin I.; Schaffer, Ayal] Univ Toronto, Sunnybrook Hlth Sci Ctr, Dept Psychiat, Toronto, ON, Canada.
   [Goldstein, Benjamin I.] Univ Pittsburgh, Sch Med, Dept Psychiat, Pittsburgh, PA USA.
   [Liu, Shang-Min; Sala, Regina; Blanco, Carlos] Columbia Univ, Dept Psychiat, New York, NY USA.
C3 University of Toronto; Sunnybrook Research Institute; Sunnybrook Health
   Science Center; Pennsylvania Commonwealth System of Higher Education
   (PCSHE); University of Pittsburgh; Columbia University
RP Goldstein, BI (corresponding author), Sunnybrook Hlth Sci Ctr, Dept Psychiat, 2075 Bayview Ave, Toronto, ON M4N 3M5, Canada.
EM benjamin.goldstein@sunnybrook.ca
RI Goldstein, Benjamin/ADR-2374-2022; Blanco, Carlos/I-4906-2013
OI Blanco, Carlos/0000-0001-6187-3057
FU National Institute on Alcohol Abuse and Alcoholism (Bethesda, MD, USA);
   NIH [DA019606, DA020783, DA023200, DA023973, MH076051, MH082773,
   CA133050]; Pfizer; AstraZeneca; Bristol-Myers Squibb; Eli Lilly Co.;
   Lundbeck
FX The National Epidemiologic Survey on Alcohol and Related Conditions
   (NESARC) is supported by the National Institute on Alcohol Abuse and
   Alcoholism (Bethesda, MD, USA) with supplemental support from the
   National Institute on Drug Abuse (Bethesda, MD, USA). The views and
   opinions expressed in this article are those of the authors and should
   not be construed to represent the views of the sponsoring organizations.
   Work on this manuscript was supported by NIH grants DA019606, DA020783,
   DA023200, DA023973, MH076051, MH082773, and CA133050 (CB).BIG has
   received grant support from Pfizer; and honoraria from Purdue Pharma. AS
   has received grant support from AstraZeneca and Pfizer; and has served
   on the speakers' bureau or received consulting fees or honoraria from
   AstraZeneca, Bristol-Myers Squibb, Eli Lilly & Co., Lundbeck, and
   Pfizer. S-ML, RS, and CB have no competing interests to report.
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NR 42
TC 51
Z9 53
U1 0
U2 16
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1398-5647
EI 1399-5618
J9 BIPOLAR DISORD
JI Bipolar Disord.
PD MAY
PY 2013
VL 15
IS 3
BP 284
EP 293
DI 10.1111/bdi.12035
PG 10
WC Clinical Neurology; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Psychiatry
GA 136OV
UT WOS:000318372100006
PM 23286532
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Janssen, I
   LeBlanc, AG
AF Janssen, Ian
   LeBlanc, Allana G.
TI Systematic review of the health benefits of physical activity and
   fitness in school-aged children and youth
SO INTERNATIONAL JOURNAL OF BEHAVIORAL NUTRITION AND PHYSICAL ACTIVITY
LA English
DT Review
ID BODY-MASS INDEX; BONE-MINERAL DENSITY; LOW CARDIORESPIRATORY FITNESS;
   CARDIOVASCULAR RISK-FACTORS; BLOOD-PRESSURE; EXERCISE PROGRAM; OBESE
   CHILDREN; INSULIN SENSITIVITY; OVERWEIGHT CHILDREN; ACTIVITY GUIDELINES
AB Background: The purpose was to: 1) perform a systematic review of studies examining the relation between physical activity, fitness, and health in school-aged children and youth, and 2) make recommendations based on the findings.
   Methods: The systematic review was limited to 7 health indicators: high blood cholesterol, high blood pressure, the metabolic syndrome, obesity, low bone density, depression, and injuries. Literature searches were conducted using predefined keywords in 6 key databases. A total of 11,088 potential papers were identified. The abstracts and full-text articles of potentially relevant papers were screened to determine eligibility. Data was abstracted for 113 outcomes from the 86 eligible papers. The evidence was graded for each health outcome using established criteria based on the quantity and quality of studies and strength of effect. The volume, intensity, and type of physical activity were considered.
   Results: Physical activity was associated with numerous health benefits. The dose-response relations observed in observational studies indicate that the more physical activity, the greater the health benefit. Results from experimental studies indicate that even modest amounts of physical activity can have health benefits in high-risk youngsters (e. g., obese). To achieve substantive health benefits, the physical activity should be of at least a moderate intensity. Vigorous intensity activities may provide even greater benefit. Aerobic-based activities had the greatest health benefit, other than for bone health, in which case high-impact weight bearing activities were required.
   Conclusion: The following recommendations were made: 1) Children and youth 5-17 years of age should accumulate an average of at least 60 minutes per day and up to several hours of at least moderate intensity physical activity. Some of the health benefits can be achieved through an average of 30 minutes per day. [Level 2, Grade A]. 2) More vigorous intensity activities should be incorporated or added when possible, including activities that strengthen muscle and bone [Level 3, Grade B]. 3) Aerobic activities should make up the majority of the physical activity. Muscle and bone strengthening activities should be incorporated on at least 3 days of the week [Level 2, Grade A].
C1 [Janssen, Ian; LeBlanc, Allana G.] Queens Univ, Sch Kinesiol & Hlth Studies, Kingston, ON, Canada.
   [Janssen, Ian] Queens Univ, Dept Epidemiol & Community Hlth, Kingston, ON, Canada.
C3 Queens University - Canada; Queens University - Canada
RP Janssen, I (corresponding author), Queens Univ, Sch Kinesiol & Hlth Studies, Kingston, ON, Canada.
EM ian.janssen@queensu.ca
RI LeBlanc, Allana/AAX-1651-2021; Janssen, Ian/B-7700-2009
OI Janssen, Ian/0000-0003-2159-3012; LeBlanc, Allana/0000-0002-4468-6783
FU Public Health Agency of Canada
FX Production of this paper has been made possible through a financial
   contribution from the Public Health Agency of Canada. The views
   expressed herein do not necessarily represent the views of the Public
   Health Agency of Canada. The leadership and administrative assistance
   was provided by the Canadian Society for Exercise Physiology.
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NR 116
TC 3254
Z9 3734
U1 30
U2 840
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1479-5868
J9 INT J BEHAV NUTR PHY
JI Int. J. Behav. Nutr. Phys. Act.
PD MAY 11
PY 2010
VL 7
AR 40
DI 10.1186/1479-5868-7-40
PG 16
WC Nutrition & Dietetics; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nutrition & Dietetics; Physiology
GA 625NN
UT WOS:000279902200003
PM 20459784
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Raghunandan, M
   Yeo, JE
   Walter, R
   Saito, K
   Harvey, AJ
   Ittershagen, S
   Lee, EA
   Yang, J
   Hoatlin, ME
   Bielinsky, AK
   Hendrickson, EA
   Schärer, O
   Sobeck, A
AF Raghunandan, Maya
   Yeo, Jung Eun
   Walter, Ryan
   Saito, Kai
   Harvey, Adam J.
   Ittershagen, Stacie
   Lee, Eun-A
   Yang, Jihyeon
   Hoatlin, Maureen E.
   Bielinsky, Anja K.
   Hendrickson, Eric A.
   Scharer, Orlando
   Sobeck, Alexandra
TI Functional cross talk between the Fanconi anemia and ATRX/DAXX histone
   chaperone pathways promotes replication fork recovery
SO HUMAN MOLECULAR GENETICS
LA English
DT Article
ID ATR-X SYNDROME; DNA-REPAIR; UBIQUITIN LIGASE; SYNDROME PROTEIN; VARIANT
   H3.3; FANCD2; COMPLEX; RESTART; STRESS; DAXX
AB Fanconi anemia (FA) is a chromosome instability syndrome characterized by increased cancer predisposition. Specifically, the FA pathway functions to protect genome stability during DNA replication. The central FA pathway protein, FANCD2, locates to stalled replication forks and recruits homologous recombination (HR) factors such as CtBP interacting protein (CtIP) to promote replication fork restart while suppressing new origin firing. Here, we identify alpha-thalassemia retardation syndrome X-linked (ATRX) as a novel physical and functional interaction partner of FANCD2. ATRX is a chromatin remodeler that forms a complex with Death domain-associated protein 6 (DAXX) to deposit the histone variant H3.3 into specific genomic regions. Intriguingly, ATRX was recently implicated in replication fork recovery; however, the underlying mechanism(s) remained incompletely understood. Our findings demonstrate that ATRX forms a constitutive protein complex with FANCD2 and protects FANCD2 from proteasomal degradation. ATRX and FANCD2 localize to stalled replication forks where they cooperate to recruit CtIP and promote MRE11 exonuclease-dependent fork restart while suppressing the firing of new replication origins. Remarkably, replication restart requires the concerted histone H3 chaperone activities of ATRX/DAXX and FANCD2, demonstrating that coordinated histone H3 variant deposition is a crucial event during the reinitiation of replicative DNA synthesis. Lastly, ATRX also cooperates with FANCD2 to promote the HR-dependent repair of directly induced DNA double-stranded breaks. We propose that ATRX is a novel functional partner of FANCD2 to promote histone deposition-dependent HR mechanisms in S-phase.
C1 [Raghunandan, Maya; Walter, Ryan; Saito, Kai; Harvey, Adam J.; Bielinsky, Anja K.; Hendrickson, Eric A.; Sobeck, Alexandra] Univ Minnesota, Dept Biochem Mol Biol & Biophys, Minneapolis, MN USA.
   [Yeo, Jung Eun; Lee, Eun-A; Yang, Jihyeon; Scharer, Orlando] Inst Basic Sci IBS, Ctr Genom Integr CGI, Ulsan, South Korea.
   [Ittershagen, Stacie; Hoatlin, Maureen E.] Oregon Hlth & Sci Univ, Dept Biochem & Mol Biol, Portland, OR 97239 USA.
   [Scharer, Orlando] Ulsan Natl Inst Sci & Technol, Sch Life Sci, Ulsan, South Korea.
C3 University of Minnesota System; University of Minnesota Twin Cities;
   Institute for Basic Science - Korea (IBS); Oregon Health & Science
   University; Ulsan National Institute of Science & Technology (UNIST)
RP Sobeck, A (corresponding author), MCB, 420 Washington Ave SE, Minneapolis, MN 55455 USA.
EM asobeck@umn.edu
RI Sobeck, Alexandra/KVY-0284-2024; Raghunandan, Maya/J-6299-2019;
   Ittershagen, Stacie/X-7658-2019
OI Raghunandan, Maya/0000-0002-0376-5880; Bielinsky,
   Anja/0000-0003-1783-619X; Ittershagen, Stacie
   (Stone)/0000-0003-3834-176X
FU American Cancer Society [RSG-13-039-01-DMC]; National Institutes of
   Health [CA112775, CA194871, GM088351]; National Cancer Institute
   [CA190492]; National Institutes of General Medical Sciences [GM 074917];
   Korean Institute for Basic Science [IBS-R022-A1]; Brainstorm award
FX Work in the Sobeck laboratory was funded, in part, by the American
   Cancer Society (RSG-13-039-01-DMC) and the National Institutes of Health
   (CA194871). Work in the Hendrickson laboratory was funded, in part, by a
   grant from the National Institutes of Health (GM088351) and from a grant
   from the National Cancer Institute (CA190492). A portion of this work
   was also funded by a Brainstorm award, administered by the University of
   Min-nesota's NCI-designated Cancer Center. Work in the Bielinsky lab was
   funded by a grant from the National Institutes of General Medical
   Sciences (GM 074917). Work in the Yeo and Scharer laboratorieswas
   supported by the Korean Institute for Basic Science (IBS-R022-A1). Work
   in the Hoatlin laboratory was funded by the National Institutes of
   Health (CA112775).
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NR 61
TC 23
Z9 24
U1 1
U2 8
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0964-6906
EI 1460-2083
J9 HUM MOL GENET
JI Hum. Mol. Genet.
PD APR 1
PY 2020
VL 29
IS 7
BP 1083
EP 1095
DI 10.1093/hmg/ddz250
PG 13
WC Biochemistry & Molecular Biology; Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Genetics & Heredity
GA NJ2LI
UT WOS:000565877200003
PM 31628488
OA Green Published
DA 2025-06-11
ER

PT J
AU Knox, G
   Baker, JS
   Davies, B
   Faulkner, S
   Rance, J
   Rees, A
   Morgan, K
   Thomas, N
AF Knox, Gareth
   Baker, Julien S.
   Davies, Bruce
   Faulkner, Susan
   Rance, Jaynie
   Rees, Anwen
   Morgan, Kelly
   Thomas, Non
TI A cross-curricular physical activity intervention to combat
   cardiovascular disease risk factors in 11-14 year olds: 'Activity
   Knowledge Circuit'
SO BMC PUBLIC HEALTH
LA English
DT Article
ID METABOLIC SYNDROME; INSULIN-RESISTANCE; BODY-FAT; CHILDREN; HEALTH;
   ADOLESCENTS; PROGRAM; FITNESS; ASSOCIATIONS; DEPRESSION
AB Background: Cardiovascular disease is the leading cause of mortality worldwide. Risk factors associated with cardiovascular disease have been shown to track from childhood through to adulthood. Previous school-based physical activity interventions have demonstrated modest improvements to cardiovascular disease risk factors by implementing extra-curricular activities or improving current physical education curriculum. Few have attempted to increase physical activity in class-room taught curriculum subjects. This study will outline a school-based cross-curricular physical activity intervention to combat cardiovascular disease risk factors in 11-14 year old children.
   Method/Design: A South Wales Valley school of low socio-economic status has been selected to take part. Participants from year eight (12-13 years) are to be assigned to an intervention group, with maturation-matched participants from years seven (11-12 years) and nine (13-14 years) assigned to a control group. A cross-curricular physical activity intervention will be implemented to increase activity by two hours a week for 18 weeks. Participants will briskly walk 3200 m twice weekly during curriculum lessons (60 minutes duration). With the exception of physical education, all curriculum subjects will participate, with each subject delivering four intervention lessons. The intervention will be performed outdoors and on school premises. An indoor course of equal distance will be used during adverse weather conditions. Cardiovascular disease risk factors will be measured pre- and post-intervention for intervention and control groups. These will take place during physical education lessons and will include measures of stature, mass, waist, hip, and neck circumferences, together with skinfold measure's taken at four sites. Blood pressure will be measured, and fitness status assessed via the 20 m multi-stage fitness test. Questionnaires will be used to determine activity behaviour ( physical activity questionnaire for adolescence), diet (seven day food diary) and maturation status. Fasting blood variables will include total cholesterol, low-density lipoprotein cholesterol, high density lipoprotein cholesterol, triglycerides, insulin, glucose, high-sensitivity C-reactive protein, interleukin-6, adiponectin, and fibrinogen. Motivational variables and psychological well-being will be assessed by questionnaire.
   Discussion: Our study may prove to be a cost effective strategy to increase school time physical activity to combat cardiovascular disease risk factors in children.
C1 [Knox, Gareth; Rees, Anwen; Morgan, Kelly] Univ Wales Coll Cardiff, Inst Cardiff, Cardiff Sch Sport, Cardiff CF1 3NS, S Glam, Wales.
   [Davies, Bruce] Univ Glamorgan, Fac Hlth Sport & Sci, Pontypridd CF37 1DL, M Glam, Wales.
   [Faulkner, Susan] Univ Glamorgan, Dept Psychol Careers & Educ, Pontypridd CF37 1DL, M Glam, Wales.
   [Rance, Jaynie] Swansea Univ, Sch Hlth Sci, Swansea, W Glam, Wales.
   [Thomas, Non] Swansea Univ, Sch Human Sci, Swansea, W Glam, Wales.
C3 Cardiff Metropolitan University; Cardiff University; University of South
   Wales; University of South Wales; Swansea University; Swansea University
RP Knox, G (corresponding author), Univ Wales Coll Cardiff, Inst Cardiff, Cardiff Sch Sport, Cardiff CF1 3NS, S Glam, Wales.
EM gaknox@uwic.ac.uk; Julien.Baker@uws.ac.uk; bdavies1@glam.ac.uk;
   sfaulkne@glam.ac.uk; J.Y.Rance@swansea.ac.uk; anrees@uwic.ac.uk;
   kelly_morgan1987@hotmail.co.uk; N.E.Thomas@swansea.ac.uk
RI Morgan, Kelly/ABX-4155-2022
OI Rance, Jaynie/0000-0002-9504-0675
FU Sports Council Wales
FX This work has been funded by a grant from the Sports Council Wales. The
   authors would like to express their thanks to the pupils and staff of
   Porth County Community School, Rhondda Cynon Taff.
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NR 52
TC 5
Z9 9
U1 0
U2 16
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2458
J9 BMC PUBLIC HEALTH
JI BMC Public Health
PD DEC 15
PY 2009
VL 9
AR 466
DI 10.1186/1471-2458-9-466
PG 8
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA 541HX
UT WOS:000273407000002
PM 20003492
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU O'Connor, PJ
   Haapala, JL
   Dehmer, SP
   Chumba, LN
   Ekstrom, HL
   Asche, SE
   Rehrauer, DJ
   Pankonin, MA
   Pawloski, PA
   Raebel, M
   Sperl-Hillen, JM
AF O'Connor, Patrick J.
   Haapala, Jacob L.
   Dehmer, Steven P.
   Chumba, Lilian N.
   Ekstrom, Heidi L.
   Asche, Stephen E.
   Rehrauer, Dan J.
   Pankonin, Melissa A.
   Pawloski, Pamala A.
   Raebel, Marsha
   Sperl-Hillen, JoAnn M.
TI Clinical Decision Support and Cardiometabolic Medication Adherence A
   Randomized Clinical Trial
SO JAMA NETWORK OPEN
LA English
DT Article
ID SKILLS MODEL; DEPRESSION; THERAPY; CARE; HYPERTENSION; PERSISTENCE;
   MANAGEMENT; DISEASE; IMPACT
AB ImportanceMedication adherence is important for managing blood pressure (BP), low-density lipoprotein cholesterol (LDL-C), and hemoglobin A1c (HbA1c). Interventions to improve medication adherence are needed. ObjectiveTo examine the effectiveness of an intervention using algorithmic identification of low medication adherence, clinical decision support to physicians, and pharmacist outreach to patients to improve cardiometabolic medication adherence and BP, LDL-C, and HbA1c control. Design, Setting, and ParticipantsA 2-arm, patient-randomized, parallel group clinical trial was conducted. Twenty-six primary care clinics using effective decision support to encourage timely adjustments of cardiometabolic medications were included. On the date of an index visit, participants were (1) aged 18 to 75 years, (2) receiving a statin or not at the goal level for HbA1c or BP, and (3) had proportion of days covered less than 80% for 1 or more BP or noninsulin glucose-lowering medications or a statin. The study was conducted from August 19, 2020, to September 30, 2023. Data analysis was performed from October 1, 2023, to August 30, 2024. InterventionElectronic health record-linked clinical decision support identified and encouraged discussion of medication adherence issues. For patients in the intervention cohort continuing to meet eligibility criteria 6 months after an index visit, pharmacist telephone outreach was attempted. Main Outcomes and MeasuresThe main outcomes of the trial were (1) adherence to selected classes of cardiometabolic medications, (2) control of HbA1c, BP, or LDL-C levels at 12 months after the index visit, and (3) costs of care. ResultsAmong 5421 participants (2990 [55%] male; mean [SD] age, 57 [11] years) 12 months after the index date, intervention patients had better adherence to BP medications (adjusted odds ratio [AOR], 1.29; 95% CI, 1.06-1.56), but no better adherence to statins (AOR, 1.18; 95% CI, 0.99-1.41) or noninsulin diabetes medications (AOR, 1.03; 95% CI, 0.82-1.30) compared with patients receiving usual care. The intervention did not improve mean HbA1c (-0.2%; 95% CI, -0.4 to 0.1), systolic BP (1.4 mm Hg; 95% CI, -0.8 to 3.5 mm Hg), or LDL-C (-1.8 mg/dL; 95% CI, -6.5 to 2.8 mg/dL). Compared with usual care, intervention patients eligible for pharmacist outreach had improved HbA1c (-0.4%; 95% CI, -0.8% to -0.1%) compared with those not eligible for outreach (-0.0; 95% CI, -0.3% to 0.3%). Health care use costs did not differ significantly between study arms. Conclusions and RelevanceThis cost-neutral intervention increased adherence to BP medications, but not to statins or glucose-lowering medications, with no overall improvement in BP, LDL-C, or HbA1c control. Modifications of this intervention strategy are needed to improve cardiometabolic risk factor control. Trial RegistrationClinicalTrials.gov Identifier: NCT03748420
C1 [O'Connor, Patrick J.; Haapala, Jacob L.; Dehmer, Steven P.; Chumba, Lilian N.; Ekstrom, Heidi L.; Asche, Stephen E.; Pawloski, Pamala A.; Sperl-Hillen, JoAnn M.] HealthPartners Inst, 8170 33rd Ave S, Bloomington, MN 55425 USA.
   [Rehrauer, Dan J.; Pankonin, Melissa A.] Healthpartners, Bloomington, MN USA.
   [Raebel, Marsha] Kaiser Permanente Colorado, Inst Hlth Res, Aurora, CO USA.
C3 HealthPartners Institute for Education & Research; HealthPartners
   Institute for Education & Research; Kaiser Permanente
RP O'Connor, PJ (corresponding author), HealthPartners Inst, 8170 33rd Ave S, Bloomington, MN 55425 USA.
EM patrick.j.oconnor@healthpartners.com
RI Pawloski, Pamala/KQU-2396-2024; Chumba, Lilian/HNS-4867-2023
FU NIH [R01HL136937]
FX This study was funded by NIH grant R01HL136937 to Health Partners
   Institute, Minneapolis, Minnesota.
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NR 35
TC 0
Z9 0
U1 0
U2 0
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 2574-3805
J9 JAMA NETW OPEN
JI JAMA Netw. Open
PD JAN 9
PY 2025
VL 8
IS 1
AR e2453745
DI 10.1001/jamanetworkopen.2024.53745
PG 15
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA R9W7H
UT WOS:001394862500002
PM 39786775
OA gold
DA 2025-06-11
ER

PT J
AU Kato, Y
   Shigehara, K
   Nakagawa, T
   Kawaguchi, S
   Izumi, K
   Kadono, Y
   Mizokami, A
AF Kato, Yuki
   Shigehara, Kazuyoshi
   Nakagawa, Tomomi
   Kawaguchi, Shohei
   Izumi, Kouji
   Kadono, Yoshifumi
   Mizokami, Atsushi
TI Relation between athletic club affiliation from school age and future
   serum free testosterone levels in Japan: A cross-sectional study
SO HEALTH SCIENCE REPORTS
LA English
DT Article
DE athletic club affiliation; hypogonadism; testosterone
ID METABOLIC SYNDROME; CARDIOVASCULAR EVENTS; DIAGNOSTIC-CRITERIA;
   EXERCISE; RISK; MEN; PREVENTION; RESISTANCE; PREDICTOR; SOCIETY
AB Background and AimsTestosterone deficiency is often related to geriatric syndrome including erectile dysfunction, osteo-porosis, depression, cognitive impairment, cardiovascular diseases and frailty. Despite the existence of many studies on short-term exercise and serum testosterone levels, few research have focused on exercise habits from young age and testosterone values in middle-aged male. In this study, we investigated whether belonging to an athletic club from school age could predict serum-free testosterone (FT) levels. MethodsThe subjects were 1609 middle-aged male outpatients aged 40 years or older (median: 61 years, interquartile range: 54-69) who visited our hospital. Participants had their FT values measured in the morning hours during the period from December 2007 to June 2009. A questionnaire survey on exercise habits was conducted at the same time as the measurements. The exercise habit questionnaire was created based on whether the patients belonged to an athletic club in (a) elementary school, (b) junior high school, (c) high school, (d) college, (e) adult life, and (f) at the time of the test. ResultsThere was only one positive response to the questionnaire among 456 patients (28% of total), followed by zero for 358 patients (22% of total). The number of patients with low-testosterone levels (FT < 8.5 pg/mL) according to the Japanese diagnostic criteria for late-onset of hypogonadism was 839 (52.1%). In multivariate analysis, it was shown that with low-testosterone levels (FT < 8.5 pg/mL), age (odds ratio [OR]: 1.065, 95% confidence interval [CI]: 1.052-1.079; p < 0.001), hypertension (OR: 3.489, 95% CI: 2.728-4.462; p < 0.001), type-2 diabetes (OR: 3.035, 95% CI: 2.296-4.01; p < 0.001), and dyslipidemia (OR: 2.039, 95% CI: 1.558-2.668; p < 0.001) were risk factors, and more than two positive responses to the questionnaire (OR: 0.886, 95% CI: 0.802-0.980; p = 0.018) were also a significant independent factor. ConclusionA sports club membership during school years may affect future testosterone levels.
C1 [Kato, Yuki; Shigehara, Kazuyoshi; Nakagawa, Tomomi; Kawaguchi, Shohei; Izumi, Kouji; Kadono, Yoshifumi; Mizokami, Atsushi] Kanazawa Univ, Dept Integrat Canc Therapy & Urol, Grad Sch Med Sci, Kanazawa, Japan.
   [Kato, Yuki; Shigehara, Kazuyoshi; Mizokami, Atsushi] Wajima Municipal Hosp, Depatment Urol, Wajima, Japan.
   [Kato, Yuki] Kanazawa Univ, Grad Sch Med Sci, Dept Integrat Canc Therapy & Urol, 13-1 Takaramachi, Kanazawa, Ishikawa 9208641, Japan.
C3 Kanazawa University; Kanazawa University
RP Kato, Y (corresponding author), Kanazawa Univ, Grad Sch Med Sci, Dept Integrat Canc Therapy & Urol, 13-1 Takaramachi, Kanazawa, Ishikawa 9208641, Japan.
EM kato1402@gmail.com
RI Izumi, Kouji/C-5973-2015; Kawaguchi, Shohei/AGE-9588-2022; Kato,
   Yuki/GWZ-6431-2022
OI kato, Yuki/0000-0002-1833-5381
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NR 31
TC 0
Z9 0
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
EI 2398-8835
J9 HEALTH SCI REP-US
JI Health Sci. Rep.
PD AUG
PY 2023
VL 6
IS 8
AR e1496
DI 10.1002/hsr2.1496
PG 7
WC Public, Environmental & Occupational Health; Medicine, General &
   Internal
WE Emerging Sources Citation Index (ESCI)
SC Public, Environmental & Occupational Health; General & Internal Medicine
GA P2PC0
UT WOS:001049100600001
PM 37599654
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Fentie, D
   Yibabie, S
AF Fentie, Dilnessa
   Yibabie, Shegaye
TI Magnitude and associated factors of dyslipidemia among patients with
   severe mental illness in dire Dawa, Ethiopia: neglected public health
   concern
SO BMC CARDIOVASCULAR DISORDERS
LA English
DT Article
DE Dyslipidemia; Dire Dawa; Schizophrenia; Hypercholesterolemia;
   Atherosclerosis
ID CARDIOVASCULAR RISK-FACTORS; METABOLIC SYNDROME; PREVALENCE; ADULTS
AB BackgroundLipid metabolism abnormalities are an emerging risk factor for cardiovascular diseases. Due to the nature of the condition and their unhealthy lifestyles, patients with mental illnesses have a doubled risk of morbidity and mortality from dyslipidemia compared to the general population. To our knowledge the magnitude of dyslipidemia in patients with mental illnesses in the eastern Ethiopia has not been reported in the literature to date. Therefore, the aim of the study was to assess and compare the magnitude of dyslipidemia and its predictors among patients with severe mental illnesses and non-mentally ill control patients.MethodsNighty six subjects with serious psychiatric disorders and nighty six matched non-psychiatric control subjects who had no history of psychiatric illness were underwent a lipid profile test in Dire Dawa referral hospital, Ethiopia. The mentally ill clients were 18 years of age and older with schizophrenia, major depression, and bipolar disorders. Exposed study subjects were matched to control by age and sex. The data were cleaned and analyzed using SPSS software. A binary logistic regression model was used to determine the factors related to the magnitude of dyslipidemia. Both the crude odds ratio and the adjusted odds ratio with a 95% confidence interval were estimated.ResultsThe magnitude of dyslipidemia among mentally ill patients was significantly higher (63.54%) compared to non-exposed controls (31.9%) in the subjects studied. In multiple logistic regression, urban dwellers were six times (AOR = 6.14, 95% CI: 1.2, 16) more likely at risk of developing dyslipidemia compared to rural participants. Similarly, physically inactive participants were nearly two-times (AOR = 1.8, 95% CI: 1.1, 12.9) more likely to develop dyslipidemia compared to physically active study participants. Moreover, study participants who had raised body mass index were 2.1 times (AOR = 2.1, 95% CI: 1.17, 15.3) more likely having dyslipidemia than their counterparts.ConclusionsThis study revealed that the prevalence of dyslipidemia is higher among mentally ill patients compared to non-mentally ill control study participants. Place of residence, physical inactivity, and raised BMI were significantly associated with dyslipidemia. Therefore, intensive screening of patients for dyslipidemia and its components is necessary during follow-up.
C1 [Fentie, Dilnessa; Yibabie, Shegaye] Dire Dawa Univ, Med & Hlth Sci Coll, Med Dept, Dire Dawa, Ethiopia.
RP Fentie, D (corresponding author), Dire Dawa Univ, Med & Hlth Sci Coll, Med Dept, Dire Dawa, Ethiopia.
EM fagitaabo@gmail.com
OI YIBABIE, SHEGAYE/0009-0007-0277-1705
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NR 33
TC 6
Z9 6
U1 1
U2 1
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1471-2261
J9 BMC CARDIOVASC DISOR
JI BMC Cardiovasc. Disord.
PD JUN 13
PY 2023
VL 23
IS 1
AR 298
DI 10.1186/s12872-023-03327-3
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA I7AS7
UT WOS:001004281300002
PM 37312056
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Clanton, NR
   Klosky, JL
   Li, CH
   Jain, N
   Srivastava, DK
   Mulrooney, D
   Zeltzer, L
   Stovall, M
   Robison, LL
   Krull, KR
AF Clanton, Nancy R.
   Klosky, James L.
   Li, Chenghong
   Jain, Neelam
   Srivastava, Deo Kumar
   Mulrooney, Daniel
   Zeltzer, Lonnie
   Stovall, Marilyn
   Robison, Leslie L.
   Krull, Kevin R.
TI Fatigue, Vitality, Sleep, and Neurocognitive Functioning in Adult
   Survivors of Childhood Cancer A Report From the Childhood Cancer
   Survivor Study
SO CANCER
LA English
DT Article
DE Childhood Cancer Survivor Study; neurocognitive; sleep; fatigue;
   vitality
ID LONG-TERM SURVIVORS; HODGKINS-DISEASE SURVIVORS; QUALITY-OF-LIFE;
   NEUROPSYCHOLOGICAL PERFORMANCE; METABOLIC SYNDROME; CHEMOTHERAPY;
   DISTURBANCE; DEPRESSION; DISORDERS; SEQUELAE
AB BACKGROUND: Long-term survivors of childhood cancer are at risk for fatigue, sleep problems, and neurocognitive impairment, although the association between these outcomes has not been previously examined. METHODS: Outcomes were evaluated in 1426 survivors from the Childhood Cancer Survivor Study using a validated Neurocognitive Questionnaire. Relative risks for neurocognitive impairment were calculated using demographic and treatment factors, and survivors' report on the Functional Assessment of Chronic Illness Therapy-Fatigue, the Short Form-36 Vitality Scale, the Pittsburgh Sleep Quality Index, and the Epworth Sleepiness Scale. RESULTS: Neurocognitive impairment was identified in >20% of survivors, using sibling-based norms for comparison. Multivariate logistic regression models revealed that fatigue (risk ratio [RR], 1.34; 95% confidence interval [CI], 1.13-1.59), daytime sleepiness (RR, 1.68; 95% CI, 1.55-1.83), poor sleep quality (RR, 1.23; 95% CI, 1.01-1.49), and decreased vitality (RR, 1.75; 95% CI 1.33-2.30) were all associated with impaired task efficiency. Likewise, fatigue (RR, 1.77; 95% CI, 1.23-2.55), sleepiness (RR, 1.38; 95% CI, 1.14-1.67), and decreased vitality (RR, 3.08; 95% CI, 1.98-4.79) were predictive of emotional regulation problems. Diminished organization was associated with increased sleepiness (RR, 1.80; 95% CI, 1.31-2.48) and decreased vitality (RR, 1.90; 95% CI, 1.37-2.63). Impaired memory was associated with poor sleep quality (RR, 1.45; 95% CI, 1.19-1.76), increased sleepiness (RR, 2.05; 95% CI, 1.63-2.58), and decreased vitality (RR, 2.01; 95% CI, 1.42-2.86). The impact of fatigue, sleepiness, sleep quality, and vitality on neurocognitive outcomes was independent of the effects of cranial radiation therapy, steroids and antimetabolite chemotherapy, sex, and current age. CONCLUSIONS: Neurocognitive function in long-term survivors of childhood cancer appears particularly vulnerable to the effects of fatigue and sleep disruption. These findings suggest sleep hygiene should be emphasized among survivors, as it may provide an additional mechanism for intervention to improve neurocognitive outcomes. Cancer 2011; 117: 2559-68. (C) 2011 American Cancer Society.
C1 [Jain, Neelam; Robison, Leslie L.; Krull, Kevin R.] St Jude Childrens Res Hosp, Dept Epidemiol & Canc Control, Memphis, TN 38105 USA.
   [Clanton, Nancy R.; Klosky, James L.] St Jude Childrens Res Hosp, Dept Psychol, Memphis, TN 38105 USA.
   [Li, Chenghong; Srivastava, Deo Kumar] St Jude Childrens Res Hosp, Dept Biostat, Memphis, TN 38105 USA.
   [Mulrooney, Daniel] Univ Minnesota, Sch Med, Dept Pediat, Minneapolis, MN 55455 USA.
   [Zeltzer, Lonnie] Univ Calif Los Angeles, David Geffen Sch Med, Dept Pediat, Los Angeles, CA 90095 USA.
   [Zeltzer, Lonnie] Univ Calif Los Angeles, David Geffen Sch Med, Dept Anesthesiol, Los Angeles, CA 90095 USA.
   [Zeltzer, Lonnie] Univ Calif Los Angeles, David Geffen Sch Med, Dept Psychiat, Los Angeles, CA 90095 USA.
   [Stovall, Marilyn] Univ Texas MD Anderson Canc Ctr, Dept Radiat Phys, Houston, TX 77030 USA.
C3 St Jude Children's Research Hospital; St Jude Children's Research
   Hospital; St Jude Children's Research Hospital; University of Minnesota
   System; University of Minnesota Twin Cities; University of California
   System; University of California Los Angeles; University of California
   Los Angeles Medical Center; David Geffen School of Medicine at UCLA;
   University of California System; University of California Los Angeles;
   University of California Los Angeles Medical Center; David Geffen School
   of Medicine at UCLA; University of California System; University of
   California Los Angeles; University of California Los Angeles Medical
   Center; David Geffen School of Medicine at UCLA; University of Texas
   System; UTMD Anderson Cancer Center
RP Krull, KR (corresponding author), St Jude Childrens Res Hosp, Dept Epidemiol & Canc Control, 262 Danny Thomas Pl,MS 735, Memphis, TN 38105 USA.
EM kevin.krull@stjude.org
RI hayashi, robert/AAH-2077-2019; Srivastava, Deo/P-2435-2017; Robison,
   Leslie/N-8122-2018; Krull, Kevin/N-3882-2018
OI Krull, Kevin/0000-0002-0476-7001; Zeltzer, Lonnie/0000-0001-9306-9450
FU National Cancer Institute [CA 55727]; National Cancer Institute Cancer
   Center [CA 21765]; American, Lebanese, Syrian Associated Charities
FX This work was supported by the National Cancer Institute grant CA 55727
   (L. L. R.). Support to St. Jude Children's Research Hospital was also
   provided by the National Cancer Institute Cancer Center Support grant
   (CA 21765) and by the American, Lebanese, Syrian Associated Charities.
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NR 50
TC 128
Z9 136
U1 1
U2 27
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0008-543X
EI 1097-0142
J9 CANCER-AM CANCER SOC
JI Cancer
PD JUN 1
PY 2011
VL 117
IS 11
BP 2559
EP 2568
DI 10.1002/cncr.25797
PG 10
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Oncology
GA 767ME
UT WOS:000290859900029
PM 21484777
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Craciun, LM
   Buleu, F
   Pah, AM
   Badalica-Petrescu, M
   Bodea, O
   Man, DE
   Cosor, OC
   Iurciuc, S
   Dragan, S
   Rada, M
AF Craciun, Laura Maria
   Buleu, Florina
   Pah, Ana Maria
   Badalica-Petrescu, Marius
   Bodea, Olivia
   Man, Dana Emilia
   Cosor, Oana Catalina
   Iurciuc, Stela
   Dragan, Simona
   Rada, Maria
TI The Benefits of a Comprehensive Cardiac Rehabilitation Program for
   Patients with Acute Coronary Syndrome: A Follow-Up Study
SO JOURNAL OF PERSONALIZED MEDICINE
LA English
DT Article
DE acute coronary syndrome; secondary prevention; comprehensive cardiac
   rehabilitation program; guideline-directed medical therapy
ID SECONDARY PREVENTION; MYOCARDIAL-INFARCTION; MANAGEMENT; EXERCISE;
   OPPORTUNITIES; HYPERTENSION; GUIDELINES; ROMANIA; EVENTS
AB Background and objectives: Secondary prevention after acute coronary syndrome (ACS) is essential to reduce cardiovascular mortality and hospital readmission, ensuring patients return to normal with an improved quality of life. Thus, we investigate the benefits of a comprehensive cardiac rehabilitation (CR) program on lifestyle, risk factors and adherence to guideline-directed medical therapy (GDMT) in patients after ACS and myocardial revascularization through coronary artery by-pass grafting (CABG) or percutaneous coronary intervention (PCI).Methods: This is a prospective, longitudinal study in consecutive post-CABG or PCI patients after ACS that participated or not in a comprehensive CR. Cardiovascular risk factors, quality of life and adherence to GDMT were analyzed in terms of assessing the benefit of 12 months of comprehensive CR on reaching guidelines secondary prevention targets.Results: At the inclusion in comprehensive CR of all patients (n = 480), 85% had hypertension; 86% had elevated total cholesterol values; 69% were characterized by metabolic syndrome; 43% were obese; 31% were active smokers and 29% had type 2 diabetes mellitus. Only 26.66% (n = 128) followed the entire program for 12 months. No statistically significant differences in the prescription of GDMT at hospital discharge after myocardial revascularization between the CR (+) group (n = 128) versus CR (-) group (n = 352) (p > 0.05) were observed. After 12 moths, a significant adherence to GDMT in the CR (+) group vs. CR (-) group was recorded, as follows: antiplatelet agents (100% versus 96%, p = 0.001), beta-blockers (99% versus 92%, p = 0.02), ACE inhibitors/ARAB (89% versus 79%, p = 0.04), lipid-lowering drugs (100% versus 89%, p = 0.001). In total, 82% of the CR (+) patients had a significantly higher adherence at GDMT (82% versus 64%, p = 0.001). At 12 moths, the CR (+) group was characterized by significantly lower values than at the inclusion but some values still increased: systolic blood pressure (139.25 + 19.20 mmHg (p < 0.03)), total cholesterol (171.07 + 48.59 mg/dL (p = 0.0001)) and LDL-cholesterol (102.83 + 41.30 mg/dL (p = 0.009)). At the same time, the analysis of psychosocial factors using the HAD questionnaire revealed a statistically significant improvement in anxiety and depression scores: HAD-A score (9.1 +/- 3.7 at T0 vs. 7.1 +/- 4.2 at T1, p = 0.001) and HAD-D score (7.7 +/- 3.19 at T0 vs. 6.4 +/- 4.3 at T1, p = 0.003). A multivariable analysis, following GDMT, showed the actual value or information and training of patients regarding optimal cardiovascular risk factor control was independently associated with lower values of systolic blood pressure (R-2 = 0.48), diastolic (R-2 = 0.38), serum glucose (R-2 = 0.48), glycated hemoglobin (R-2 = 0.50), total cholesterol (R-2 = 0.31), LDL-cholesterol (R-2 = 0.30), HDL-cholesterol (R-2 = 0.19) and serum triglycerides (R-2 = 0.20).Conclusion: The twelve-month participation of post-ACS patients in comprehensive CR resulted in excellent post-revascularization management, as well as good adherence to guideline-directed medical therapy, provided further confirmation of the benefit of secondary prevention. Despite high adherence to drug treatments, targets for blood pressure, total cholesterol and LDL-cholesterol are inadequately achieved.
   Therefore, in the era of personalized medicine, patients with ACS should benefit from specific, comprehensive cardiovascular recovery programs that contain physiotherapists, psychologists, nutritionists and an experienced cardiologist in cardiovascular rehabilitation.
C1 [Craciun, Laura Maria; Buleu, Florina; Pah, Ana Maria; Badalica-Petrescu, Marius; Bodea, Olivia; Man, Dana Emilia; Cosor, Oana Catalina; Iurciuc, Stela; Dragan, Simona; Rada, Maria] Victor Babes Univ Med & Pharm, Dept Cardiol, E Murgu Sq 2, Timisoara 300041, Romania.
   [Man, Dana Emilia; Dragan, Simona] Victor Babes Univ Med & Pharm, Timisoara Inst Cardiovasc Dis, Res Ctr, Timisoara 300041, Romania.
C3 Victor Babes University of Medicine & Pharmacy, Timisoara; Victor Babes
   University of Medicine & Pharmacy, Timisoara
RP Buleu, F (corresponding author), Victor Babes Univ Med & Pharm, Dept Cardiol, E Murgu Sq 2, Timisoara 300041, Romania.
EM dr.lauracraciun@gmail.com; buleu.florina@gmail.com; ana11p@yahoo.com;
   marius_badalica@yahoo.com; olivia_maria88@yahoo.com;
   danaemilia@yahoo.com; oanacatalinaiancu@yahoo.com;
   stela_iurciuc@yahoo.com; simona.dragan@umft.ro; radamariam@gmail.com
RI Florina, Buleu/KOD-2450-2024; Craciun, Laura/JRZ-0300-2023; Dragan,
   Simona/AAA-6142-2019; Bodea, Olivia/LRT-7888-2024; Iurciuc,
   Stela/LVS-1519-2024; Movila, Emilia Dana/GSN-1471-2022; BADALICA,
   MARIUS/LVS-1160-2024; PAH, ANAMARIA/LVS-1111-2024
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NR 44
TC 3
Z9 3
U1 2
U2 7
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2075-4426
J9 J PERS MED
JI J. Pers. Med.
PD OCT
PY 2023
VL 13
IS 10
AR 1516
DI 10.3390/jpm13101516
PG 17
WC Health Care Sciences & Services; Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Health Care Sciences & Services; General & Internal Medicine
GA X6DX1
UT WOS:001099346800001
PM 37888127
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Poston, WSC
   Haddock, CK
   Jahnke, SA
   Jitnarin, N
   Day, RS
AF Poston, Walker S. C.
   Haddock, Christopher K.
   Jahnke, Sara A.
   Jitnarin, Nattinee
   Day, R. Sue
TI An examination of the benefits of health promotion programs for the
   national fire service
SO BMC PUBLIC HEALTH
LA English
DT Article
DE Health promotion; Firefighter; Obesity; Fitness
ID BODY-MASS INDEX; CENTRAL UNITED-STATES; CARDIOVASCULAR-DISEASE; CAREER
   FIREFIGHTERS; TOBACCO USE; PROFESSIONAL FIREFIGHTERS; CARDIORESPIRATORY
   FITNESS; MILITARY PERSONNEL; METABOLIC SYNDROME; PHYSICAL-ACTIVITY
AB Background: Firefighters suffer from high prevalence of obesity, substandard fitness, and cardiovascular-related deaths. There have been a limited number of firefighter health promotion programs that have been developed and empirically-tested for this important occupational group. We evaluated the health of firefighters from departments with well-developed health promotion programs and compared them with those from departments not having such programs using a large national sample of career fire departments that varied in size and mission. We measured a broad array of important individual firefighter health outcomes (e. g., body composition, physical activity, and general and behavioral health) consistent with national fire service goals and addressed significant statistical limitations unaccounted for in previous studies.
   Methods: Using the approach of purposive sampling of heterogeneous instances, we selected and conducted a national evaluation of 10 departments already implementing wellness and fitness programs (Wellness Approach; WA) with 10 departments that did not (Standard). Participants were 1,002 male firefighters (WA n = 522; Standard n = 480) who underwent assessments including body composition, fitness, and general/behavioral health (e. g., injury, depressive symptoms).
   Results: Firefighters in WA departments were healthier than their Standard department counterparts. For example, they were less likely to be obese (adjusted [A] OR = 0.58; 95% CI = 0.41-0.82), more likely to meet endurance capacity standards for firefighting (AOR = 5.19; 95% CI = 2.49-10.83) and have higher estimated VO2max (40.7 +/- 0.6 vs. 37.5 +/- 1.3 for firefighters in Standard departments; p = 0.001). In addition, WA firefighter were substantially less likely to smoke (AOR = 0.30; 95% CI = 0.17-0.54) or ever have been diagnosed with an anxiety disorder (AOR = 0.27; 95% CI = 0.14-0.52) and they expressed higher job satisfaction across several domains. However, WA firefighters were somewhat more likely to have reported an injury to Workers' Compensation (AOR = 1.74; 95% CI = 1.05-2.90). It was notable that both groups evidenced high prevalence of smokeless tobacco use and binge drinking.
   Conclusions: Firefighters in departments selected based on having strong wellness programs (WA) were healthier along a number of dimensions important to firefighter wellness and operational readiness. However, several health areas require greater attention including problematic alcohol consumption and smokeless tobacco use, suggesting that more emphasis on these behavioral health issues is needed in the fire service.
C1 [Poston, Walker S. C.; Haddock, Christopher K.; Jahnke, Sara A.; Jitnarin, Nattinee] Natl Dev & Res Inst Inc, NDRI MA, NDRI, Ctr Fire Rescue & EMS Hlth Res,Inst Biobehav Hlth, Leawood, KS 66224 USA.
   [Day, R. Sue] Univ Texas Houston, Hlth Sci Ctr, Michael & Susan Dell Ctr Hlth Living, Div Epidemiol Human Genet & Environm Sci, Houston, TX 77030 USA.
C3 University of Texas System; University of Texas Health Science Center
   Houston
RP Poston, WSC (corresponding author), Natl Dev & Res Inst Inc, NDRI MA, NDRI, Ctr Fire Rescue & EMS Hlth Res,Inst Biobehav Hlth, 1920 West 143rd St Suite 120, Leawood, KS 66224 USA.
EM carlosposton@hopehri.com
RI Jahnke, Simone/K-5982-2013
FU Assistance to Firefighters Grants program [EMW-2009-FP-01971]
FX This study was funded by a grant from the Assistance to Firefighters
   Grants program managed by the Federal Emergency Management Agency in the
   Department of Homeland Security (EMW-2009-FP-01971). The authors would
   like to thank all of the firefighters and their fire departments for
   participating in this study with the goal of improving firefighter
   health and operational readiness and the EFSP for their guidance in
   conducting this study. We also would like to thank staff members at NDRI
   (Melissa Hyder, Ph.D. and Sarah Cooper) and UTHSPH (Deirdre Douglass, R.
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NR 67
TC 81
Z9 100
U1 1
U2 34
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-2458
J9 BMC PUBLIC HEALTH
JI BMC Public Health
PD SEP 5
PY 2013
VL 13
AR 805
DI 10.1186/1471-2458-13-805
PG 14
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA 216GG
UT WOS:000324269400001
PM 24007391
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Mulloy, E
   Zhang, A
   Balladelli, F
   Del Giudice, F
   Glover, F
   Eisenberg, ML
AF Mulloy, Evan
   Zhang, Amy
   Balladelli, Federico
   Del Giudice, Francesco
   Glover, Frank
   Eisenberg, Michael L.
TI Diagnoses and medications associated with delayed ejaculation
SO SEXUAL MEDICINE
LA English
DT Article
DE ejaculation; data mining; erectile dysfunction; Peyronie's disease
ID METABOLIC SYNDROME; DYSFUNCTION; ORGASM; MEN
AB Background Delayed ejaculation (DE) is a disorder that can cause significant distress for sexually active men. The etiology of DE is largely idiopathic, with even less being known about clinical factors associated with the condition.Aim We sought to use data mining techniques to examine a broad group of health conditions and pharmaceutical treatments to identify factors associated with DE.Methods Using an insurance claims database, we evaluated all men with a diagnosis of DE and matched them to a cohort (1:1) of men with other male sexual disorders of urologic origin (ie, erectile dysfunction [ED] and Peyronie's disease [PD]). Given the low prevalence of DE, we incorporated the random forest approach for classification of DE vs controls, with a plethora of predictors and cross-validation with the least absolute shrinkage and selection operator (LASSO). We used both a high-performance generalized linear model and a multivariate logistic model. The area under the curve was reported to demonstrate classifier performance, and odds ratios were used to indicate risks of each predictor. We also evaluated for differences in the prevalence of conditions in DE by race/ethnicity.Outcomes Clinical factors (ie, diagnoses and medications) associated with DE were identified.Results In total, 11 602 men with DE were matched to a cohort of men with PD and ED. We focused on the 20 factors with the strongest association with DE across all models. The factors demonstrating positive associations with DE compared to other disorders of male sexual dysfunction (ie, ED and PD) included male infertility, testicular dysfunction, anxiety, disorders of lipid metabolism, alpha adrenergic blocker use, anemia, antidepressant use, and psychoses such as schizophrenia or schizoaffective disorder. In addition, the prevalence of several conditions varied by race/ethnicity. For example, male infertility was present in 5% of Asian men compared to <2% of men of other races.Clinical Implications Several medical conditions and pharmacologic treatments are associated with DE, findings that may provide insight into the etiology of DE and offer treatment options.Strengths and Limitations This study is to our knowledge the first to use using data mining techniques to investigate the association between medical conditions/pharmacologic agents and the development of subsequent DE. The generalizability of our findings is limited given that all men were commercially insured.Conclusion DE is associated with multiple medical conditions, a finding that may help identify the etiology for this disorder.
C1 [Mulloy, Evan; Zhang, Amy; Balladelli, Federico; Del Giudice, Francesco; Eisenberg, Michael L.] Stanford Univ, Dept Urol, Sch Med, Palo Alto, CA 94305 USA.
   [Balladelli, Federico] IRCCS Osped San Raffaele, Div Expt Oncol, Unit Urol, Milan, Italy.
   [Del Giudice, Francesco] Sapienza Univ Rome, Dept Maternal Infant & Urol Sci, Rome, Italy.
   [Glover, Frank] Emory Univ, Sch Med, Atlanta, GA USA.
C3 Stanford University; Vita-Salute San Raffaele University; IRCCS Ospedale
   San Raffaele; Sapienza University Rome; Emory University
RP Mulloy, E (corresponding author), Stanford Univ, Dept Urol, Sch Med, Palo Alto, CA 94305 USA.
EM eamulloy@gmail.com; czhang6@stanford.edu; belladelli.federico@gmail.com;
   fdelgiu@stanford.edu; feglove@emory.edu
RI Belladelli, Federico/AAN-3642-2021; Del Giudice, Francesco/ABF-8842-2021
OI Belladelli, Federico/0000-0002-2165-659X; Eisenberg,
   Michael/0000-0001-5482-0141
CR Abdel-Hamid IA, 2011, J SEX MED, V8, P1772, DOI 10.1111/j.1743-6109.2010.02131.x
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NR 25
TC 0
Z9 0
U1 0
U2 0
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
EI 2050-1161
J9 SEX MED-UK
JI Sex. Med.
PD AUG 1
PY 2023
VL 11
IS 4
AR qfad040
DI 10.1093/sexmed/qfad040
PG 5
WC Medicine, General & Internal; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Urology & Nephrology
GA U1MQ1
UT WOS:001082517300011
PM 37547871
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Liu, H
   Yang, J
   Wang, K
   Niu, TF
   Huang, DY
AF Liu, Hong
   Yang, Jie
   Wang, Kai
   Niu, Tengfei
   Huang, Dongya
TI Moderate- and Low-Dose of Atorvastatin Alleviate Cognition Impairment
   Induced by High-Fat Diet via Sirt1 Activation
SO NEUROCHEMICAL RESEARCH
LA English
DT Article
DE High-fat diet; Atorvastatin; Dosage; Cognition impairment; SIRT1
   activation
ID OXIDATIVE STRESS; METABOLIC SYNDROME; STATIN THERAPY; NEUROLOGICAL
   DEFICIT; INSULIN-RESISTANCE; SPATIAL MEMORY; UP-REGULATION; BRAIN;
   CHOLESTEROL; HIPPOCAMPUS
AB Mounting evidences have demonstrated that diet-induced obesity is associated with cognition impairment via increasing oxidative stress and inflammation in the brain. Atorvastatin (Ator, a HMG-CoA reductase inhibitor) is a cholesterol lowering drug. Studies have reported that Ator can ameliorate the development and progression of cognition impairment. Additionally, silent information regulator 1 (SIRT1) has been demonstrated to be beneficial in cognition impairment. However, the interaction between Ator and SIRT1 activation for cognition impairment remains unclear. This study aimed to identify a relationship between the use of Ator and cognition impairment induced by high-fat diet via Sirt1 activation. A total of 60 healthy male C57BL/6J mice were purchased and then divided into 6 groups, including normal diet group (control), a high-fat diet group (40%HFD, 40% energy from fat), a model group (60%HFD, 60% energy from fat), and model group treated with different doses of Ator (high-dose (80mg), moderate-dose (40mg), and low-dose (20mg) groups). All interventions took place for 7months. Metabolic phenotypes were characterized for body weight and analysis of serum lipid level. The level of cognition development was examined by Morris water maze (MWM) approach and novel object recognition test (NORT); besides, the expression of Creb1, Gap-43, BDNF, CaMKII, and ERKs of frontal cortex and hippocampus was determined by reverse transcription polymerase chain reaction (RT-PCR). Then, the levels of factors related to inflammation (TNF-a, IL-1, HMGB1 and IL-6) and oxidation stress (SOD, MDA, CAT and GSH-Px) were assessed using commercially available kits. Finally, SIRT1 and its downstream molecules (Ac-FoxO1, Ac-p53, Ac-NF-B, Bcl-2 and Bax) were evaluated by Western blot analysis. Compared with the 60% HFD group, body weight and serum lipid levels were significantly decreased in the Ator treated groups. The results of MWM and NORT, as well as the levels of Creb1, Gap-43, BDNF, CaMKII, and ERKs were markedly reversed in the moderate- and low-dose of Ator treated groups. Meanwhile, the expression of IL-1, TNF-a, IL-6, HMGB1, and MDA was notably decreased, whereas the activity of SOD, CAT, and GSH-Px was increased. It was also revealed that the expression of SIRT1 was remarkably unregulated, the level of Bcl-2 was upregulated, and the content of Ac-FoxO1, Ac-p53, Ac-NF-B, and Bax was downregulated in the moderate- and low-dose of Ator. Furthermore, results showed that the effect of moderate-dose of Ator was significantly greater than the low-dose of Ator. However, these effects were not observed in the high-dose of Ator. Our results showed that moderate- and low-dose of Ator can significantly attenuate cognition impairment induced by HFD through its antioxidant and anti-inflammatory functions related to SIRT1 activation.
C1 [Liu, Hong; Yang, Jie; Wang, Kai; Niu, Tengfei; Huang, Dongya] Tongji Univ, Sch Med, East Hosp, Dept Neurol, Shanghai 200120, Peoples R China.
C3 Tongji University
RP Huang, DY (corresponding author), Tongji Univ, Sch Med, East Hosp, Dept Neurol, Shanghai 200120, Peoples R China.
EM dongyahuang77@hotmail.com
FU National Natural Science Foundation of China [81771258]
FX This study was supported by the National Natural Science Foundation of
   China (Grant No. 81771258).
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Z9 15
U1 1
U2 20
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0364-3190
EI 1573-6903
J9 NEUROCHEM RES
JI Neurochem. Res.
PD MAY
PY 2019
VL 44
IS 5
BP 1065
EP 1078
DI 10.1007/s11064-019-02738-z
PG 14
WC Biochemistry & Molecular Biology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Neurosciences & Neurology
GA HU9RB
UT WOS:000465630500006
PM 30820818
DA 2025-06-11
ER

PT J
AU Figueras, J
   Garcia-Dorado, D
   Agulló, L
   Cortadellas, J
   Padilla, F
   Domingo, E
   Galard, R
AF Figueras, Jaume
   Garcia-Dorado, David
   Agullo, Luis
   Cortadellas, Josefa
   Padilla, Ferran
   Domingo, Enric
   Galard, Rosa
TI Activation of Polymorphonuclear Leukocytes and Increased Plasma
   Vasoconstrictors in Vasospastic and Nonvasospastic Angina
SO CANADIAN JOURNAL OF CARDIOLOGY
LA English
DT Article
ID NORMAL CORONARY ARTERIOGRAMS; CARDIAC SYNDROME-X; ENDOTHELIAL
   DYSFUNCTION; MYOCARDIAL-INFARCTION; UNSTABLE ANGINA; VARIANT ANGINA;
   SEROTONIN; PECTORIS; SPASM; INFLAMMATION
AB Background: The cause of coronary vasoconstriction in patients with angina at rest, nonsignificant coronary stenosis, and endothelial dysfunction remains unknown. Our objective was to investigate the association between enhanced coronary vasoconstriction and increased circulating levels of vasoconstrictor agents.
   Methods: Plasma levels of big endothelin-1, serotonin, and superoxide produced by polymorphonuclear leukocytes were measured in 38 patients with stable angina at rest without significant coronary artery stenosis-23 with nonvasospastic angina and 15 with vasospastic angina-and were compared with 10 patients with stable coronary disease and 20 age-matched controls.
   Results: Patients with angina at rest showed higher big endothelin-1 (1.28 vs 0.72 fmol/mL, P < 0.001), serotonin (18.0 vs 9.1 ng/mL, P = 0.002), and superoxide produced by polymorphonuclear leukocytes (177 vs 67 nmol/10 x E8 x minutes, P = 0.001) than did controls. Serotonin and superoxide produced by polymorphonuclear leukocytes were also higher than in coronary disease patients (5.4 ng/mL, P = 0.001, and 97 nmol/10 x E8 x minutes, P = 0.005), and big endothelin-1 levels tended to be higher (0.99 fmol/mL, P = 0.073). Moreover, there were no significant differences in these 3 parameters between patients with vasospastic and nonvasospastic angina, and among the latter, between patients with a positive and those with a negative exercise stress test.
   Conclusion: Systemic plasma levels of agents with the potential to produce coronary vasoconstriction are increased in patients with stable vasospastic or nonvasospastic angina and, hence, may contribute to their angina, increased coronary tone, and impaired vasodilatory capacity. Furthermore, they may establish a mechanistic link between the 2 conditions.
C1 [Figueras, Jaume] Univ Autonoma Barcelona, Unitat Coronaria, Serv Cardiol, Hosp Gen Univ Vall dHebron, Barcelona 08035, Spain.
   [Figueras, Jaume; Garcia-Dorado, David; Agullo, Luis; Cortadellas, Josefa; Padilla, Ferran; Domingo, Enric] Serv Cardiol, Lab Cardiol Expt, Barcelona, Spain.
   [Galard, Rosa] Univ Autonoma Barcelona, Hosp Gen Vall dHebron, Serv Bioquim, Barcelona 08035, Spain.
C3 Autonomous University of Barcelona; Hospital Universitari Vall d'Hebron;
   Autonomous University of Barcelona; Hospital Universitari Vall d'Hebron
RP Figueras, J (corresponding author), Univ Autonoma Barcelona, Unitat Coronaria, Serv Cardiol, Hosp Gen Univ Vall dHebron, P Vall dHebron 119-129, Barcelona 08035, Spain.
EM 5751jfb@comb.es
RI Domingo, Enric/JDV-9587-2023; Agullo, Luis/A-2747-2009
OI Agullo, Luis/0000-0002-8578-4902
FU Fundacio Recerca Biomedica i Docencia Hospital Vall d'Hebron (PR),
   Barcelona, Spain [HG 84/98]; Redes Tematicas de Investigacion
   Cooperativa (RE-CAVA) [C03/01]
FX This study was financially supported in part by a grant from the
   Fundacio Recerca Biomedica i Docencia Hospital Vall d'Hebron (PR, HG
   84/98), Barcelona, Spain, and by a grant from Redes Tematicas de
   Investigacion Cooperativa (RE-CAVA, C03/01).
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NR 26
TC 1
Z9 1
U1 0
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0828-282X
J9 CAN J CARDIOL
JI Can. J. Cardiol.
PD SEP-OCT
PY 2011
VL 27
IS 5
BP 601
EP 605
DI 10.1016/j.cjca.2011.01.004
PG 5
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 842RQ
UT WOS:000296617800015
PM 21705187
DA 2025-06-11
ER

PT J
AU Gaignard, SM
   Dave, EK
   Warnock, RK
   Bortfeld, KS
   Moncayo, VM
   Mehta, PK
AF Gaignard, Scott M.
   Dave, Esha K.
   Warnock, Rachel K.
   Bortfeld, Kristina S.
   Moncayo, Valeria M.
   Mehta, Puja K.
TI Coronary Microvascular Dysfunction in Women
SO CURRENT CARDIOVASCULAR RISK REPORTS
LA English
DT Review
DE Coronary microvascular dysfunction; Endothelial dysfunction; Persistent
   angina; Coronary atherosclerosis
ID CARDIOVASCULAR MAGNETIC-RESONANCE; ISCHEMIC-HEART-DISEASE; CARDIAC
   SYNDROME-X; ENHANCED EXTERNAL COUNTERPULSATION; ARTERY-DISEASE; FLOW
   RESERVE; MYOCARDIAL-PERFUSION; ANGINA-PECTORIS; ENDOTHELIAL FUNCTION;
   STABLE ANGINA
AB Purpose of ReviewPatients who are suspected of having symptoms from myocardial ischemia routinely undergo coronary angiography to evaluate for obstructive coronary artery disease (CAD). However, a substantial proportion of patients with ischemia are found to have no obstructive coronary arteries (INOCA), a condition that is associated with major adverse cardiovascular events and recurrent angina hospitalizations.Recent FindingsEpicardial coronary vascular dysfunction and coronary microvascular dysfunction (CMD) are prevalent in a majority of INOCA patients. CMD is prognostic in both men and women, although women have more angina and lower quality of life with this condition. CMD can be detected by non-invasive stress testing modalities, but coronary angiography with coronary function testing provides a comprehensive evaluation of vascular abnormalities in the diagnoses of CMD.SummaryTreatment of this challenging condition requires a tailored approach that includes targeting lifestyle, addressing risk factors, and use of anti-anginal strategies to manage symptoms and improve quality of life. This mini review highlights the diagnosis and management of CMD, a condition that is often underappreciated and underrecognized.
   In a patient with chest pain and no obstructive coronary artery disease, coronary vascular dysfunction in the epicardial vessels and/or the microcirculation should be considered as a potential explanation.Coronary microvascular dysfunction (CMD) is associated with major adverse cardiovascular events in both men and women.In the absence of obstructive coronary stenosis, CMD is diagnosed when coronary flow reserve is impaired or when there is high myocardial resistance.Treatment of angina in patients with CMD can improve symptoms and quality of life.
C1 [Gaignard, Scott M.; Warnock, Rachel K.; Bortfeld, Kristina S.] Emory Univ, J Willis Hurst Internal Med Residency Program, Atlanta, GA 30322 USA.
   [Dave, Esha K.; Mehta, Puja K.] Emory Univ, Emory Womens Heart Ctr, 1750 Haygood Dr Hlth Sci Res Bldg 2,2nd floor,Off, Atlanta, GA 30322 USA.
   [Dave, Esha K.; Mehta, Puja K.] Emory Univ, Emory Clin Cardiovasc Res Inst, Div Cardiol, Sch Med, 1750 Haygood Dr Hlth Sci Res Bldg 2,2nd floor,Off, Atlanta, GA 30322 USA.
   [Moncayo, Valeria M.] Emory Univ, Sch Med, Dept Radiol & Imaging Sci, Div Nucl Med & Mol Imaging, Atlanta, GA 30322 USA.
C3 Emory University; Emory University; Emory University; Emory University
RP Mehta, PK (corresponding author), Emory Univ, Emory Womens Heart Ctr, 1750 Haygood Dr Hlth Sci Res Bldg 2,2nd floor,Off, Atlanta, GA 30322 USA.; Mehta, PK (corresponding author), Emory Univ, Emory Clin Cardiovasc Res Inst, Div Cardiol, Sch Med, 1750 Haygood Dr Hlth Sci Res Bldg 2,2nd floor,Off, Atlanta, GA 30322 USA.
EM pkmehta@emory.edu
FU NIH
FX No Statement Available
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NR 136
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1932-9520
EI 1932-9563
J9 CURR CARDIOVASC RISK
JI Curr. Cardiovascu. Risk Rep.
PD JUN
PY 2024
VL 18
IS 6
BP 81
EP 93
DI 10.1007/s12170-024-00738-5
EA JUN 2024
PG 13
WC Cardiac & Cardiovascular Systems
WE Emerging Sources Citation Index (ESCI)
SC Cardiovascular System & Cardiology
GA WI1P7
UT WOS:001242299400001
DA 2025-06-11
ER

PT J
AU Wei, YH
   Liao, MH
   Lu, YM
   Lei, XC
   Wang, JL
   Luo, XQ
   Hu, LL
AF Wei, Yanhong
   Liao, Meihua
   Lu, Yiming
   Lei, Xiaocan
   Wang, Junli
   Luo, Xiaoqiong
   Hu, Linlin
TI Mapping the Landscape of Obesity Effects on Male Reproductive Function:
   A Bibliometric Study
SO ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS
LA English
DT Article
DE Obesity; male reproductive disorders; bibliometric analysis; sperm
   quality; metabolic syndrome; cardiovascular disease
ID SPERMATOGENIC DISORDERS; QUALITY; LEPTIN; MICE; FAT
AB Background: Due to changes in lifestyle and dietary habits, the global population with obesity is increasing gradually, resulting in a significant rise in the number of individuals having obesity. Obesity is caused by an imbalance between energy intake and consumption, leading to excessive fat accumulation, which interferes with normal human metabolism. It is also associated with cardiovascular disease, metabolic syndrome, male reproductive endocrine regulation disorders, systemic and local inflammatory reactions, excessive oxidative stress, and apoptosis. All these factors can damage the internal environment for sperm generation and maturation, resulting in male sexual dysfunction, a decline in sperm quality, and lower fertility. This study analyzes the trends and priorities of the effects of obesity on male reproductive disorders from a bibliometric perspective. Methods: This study uses the Web of Science as the statistical source, covering all time spans. Tools like Web of Science, VOSviewer, and CiteSpace are used to analyze countries, institutions, authors, journals, and keywords in the field. Total publications, total citations, and average number of citations are selected for statistics. Results: The results show that the research on the impact of obesity on male reproductive function can be roughly divided into three stages: the initial stage, the slow development stage, and the rapid development stage. Our statistical scope includes 463 highly relevant articles that we have screened. We found that the journal with the most publications in this field is Andrologia, and the institution with the highest total citations is the University of Utah. The most influential countries, institutions, and authors in this field are the United States, the University of Utah, and Carrell, Douglas. Currently, research related to the impact of obesity on male reproduction focuses mainly on three aspects: biochemistry, molecular biology, and reproductive biology. The keyword explosion results indicate that sperm, obesity, and male reproduction are at the forefront and trends of future research in this field. There has been a shift from basic biochemical and molecular research to research on molecular mechanisms relying on omics technologies. However, we have observed that the number of papers published in 2022 is lower than in 2021, indicating a growth interruption during this period. Considering that this deviation may be due to the impact of the COVID-19 pandemic, it may hinder the progress of certain experiments in 2022. In recent years, China has rapidly developed research in this field. However, the average citation rate is relatively low, indicating the need for Chinese scholars to improve the quality of their articles further. Based on our research and in the context of global obesity, men are at risk of increased infertility. Addressing this issue relies on our continued research into the mechanisms of obesity-related male reproductive disorders. Over the past forty-three years, with the contributions of scientists worldwide, research in this field has flourished. Conclusion: The impact of obesity on male reproductive disorders has been extensively studied. Currently, research in this field primarily focuses on male sperm function, sperm quality, and the effects or mechanisms of cells on male reproduction. Future trends in this field should concentrate on the relationship between male fertility and energy metabolism, as well as the endocrine function of adipose tissue.
   This study comprehensively analyzes the current research status and global trends in obesity and male reproductive disorders. We also discuss the future developments in this field, making it easier for researchers to understand its developmental history, current status, and trends, providing valuable reference for effective exploration in this area.
C1 [Wei, Yanhong; Liao, Meihua; Lu, Yiming; Wang, Junli; Luo, Xiaoqiong; Hu, Linlin] Youjiang Med Univ Nationalities, Guangxi Med & Hlth Key Discipline Construct Projec, Reprod Med, Affiliated Hosp, Baise 533000, Peoples R China.
   [Wei, Yanhong; Lei, Xiaocan] Univ South China, Clin Anat & Reprod Med Applicat Inst, Hengyang Med Sch, Hengyang 421001, Peoples R China.
   [Lu, Yiming; Lei, Xiaocan; Wang, Junli] Youjiang Med Univ Nationalities, Ind Coll Biomed & Hlth Ind, Baise 533000, Peoples R China.
C3 Youjiang Medical University for Nationalities; University of South
   China; Youjiang Medical University for Nationalities
RP Wei, YH; Liao, MH (corresponding author), Youjiang Med Univ Nationalities, Guangxi Med & Hlth Key Discipline Construct Projec, Reprod Med, Affiliated Hosp, Baise 533000, Peoples R China.; Wei, YH (corresponding author), Univ South China, Clin Anat & Reprod Med Applicat Inst, Hengyang Med Sch, Hengyang 421001, Peoples R China.
EM hutwolin@126.com; 710368717@qq.com
RI Hu, Linlin/IUP-0378-2023
FU Natural Science Foundation of Guangxi in China [2021GXNSFBA220010,
   2022JJA140113]
FX This work was supported by the Natural Science Foundation of Guangxi in
   China (No. 2021GXNSFBA220010 and 2022JJA140113).
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NR 53
TC 1
Z9 2
U1 1
U2 6
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1871-5303
EI 2212-3873
J9 ENDOCR METAB IMMUNE
JI Endocr. Metab. Immune Disord.-Drug Targets
PY 2024
VL 24
IS 13
BP 1546
EP 1557
DI 10.2174/0118715303271117231220072051
EA JAN 2024
PG 12
WC Endocrinology & Metabolism; Immunology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Immunology; Pharmacology & Pharmacy
GA D5J7N
UT WOS:001280858900001
PM 38299282
OA hybrid
DA 2025-06-11
ER

PT J
AU Garbarino, J
   Eckroate, J
   Sundaram, RK
   Jensen, RB
   Bindra, RS
AF Garbarino, Jennifer
   Eckroate, Jillian
   Sundaram, Ranjini K.
   Jensen, Ryan B.
   Bindra, Ranjit S.
TI Loss of ATRX confers DNA repair defects and PARP inhibitor sensitivity
SO TRANSLATIONAL ONCOLOGY
LA English
DT Article
DE ATRX; PARP inhibitor; IDH1 R132H; Glioma; DNA damage response
ID MECHANISM; MUTATION; GLIOMAS
AB Alpha Thalassemia/Mental Retardation Syndrome X-Linked (ATRX) is mutated frequently in gliomas and represents a potential target for cancer therapies. ATRX is known to function as a histone chaperone that helps incorporate histone variant, H3.3, into the genome. Studies have implicated ATRX in key DNA damage response (DDR) pathways but a distinct role in DNA repair has yet to be fully elucidated. To further investigate the function of ATRX in the DDR, we created isogenic wild-type (WT) and ATRX knockout (KO) model cell lines using CRISPR-based gene targeting. These studies revealed that loss of ATRX confers sensitivity to poly(ADP)ribose polymerase (PARP) inhibitors, which was linked to an increase in replication stress, as detected by increased activation of the ataxia telangiectasia and Rad3-related (ATR) signaling axis. ATRX mutations frequently co-occur with mutations in isocitrate dehydrogenase-1 and -2 (IDH1/2), and the latter mutations also induce HR defects and PARP inhibitor sensitivity. We found that the magnitude of PARP inhibitor sensitivity was equal in the context of each mutation alone, although no further sensitization was observed in combination, suggesting an epistatic interaction. Finally, we observed enhanced synergistic tumor cell killing in ATRX KO cells with ATR and PARP inhibition, which is commonly seen in HR-defective cells. Taken together, these data reveal that ATRX may be used as a molecular marker for DDR defects and PARP inhibitor sensitivity, independent of IDH1/2 mutations. These data highlight the important role of common glioma-associated mutations in the regulation of DDR, and novel avenues for molecularly guided therapeutic intervention.
C1 [Garbarino, Jennifer] Yale Univ, Dept Mol Biochem & Biophys, New Haven, CT 06511 USA.
   [Eckroate, Jillian; Sundaram, Ranjini K.; Jensen, Ryan B.; Bindra, Ranjit S.] Yale Univ, Sch Med, Dept Therapeut Radiol, New Haven, CT 06511 USA.
C3 Yale University; Yale University
RP Jensen, RB; Bindra, RS (corresponding author), Yale Univ, Sch Med, Dept Therapeut Radiol, New Haven, CT 06511 USA.
EM ryan.jensen@yale.edu; ranjit.bindra@yale.edu
FU National Institutes of Health [R01 CA215990, R01 CA215453]; National
   Brain Tumor Society; V Foundation BRCA Convergence award; Women's Health
   Research at Yale; Gray Foundation; American Cancer Society
   [RSG170380101]
FX This work was supported by the National Institutes of Health grants R01
   CA215990 to RBJ and R01 CA215453 to RSB. The study was further supported
   by the National Brain Tumor Society to RSB, and the V Foundation BRCA
   Convergence award, Women's Health Research at Yale, The Gray Foundation,
   and an American Cancer Society grant [RSG170380101] to RBJ.
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NR 49
TC 29
Z9 31
U1 1
U2 15
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1936-5233
J9 TRANSL ONCOL
JI Transl. Oncol.
PD SEP
PY 2021
VL 14
IS 9
AR 101147
DI 10.1016/j.tranon.2021.101147
EA JUN 2021
PG 7
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA TV8QD
UT WOS:000681980000006
PM 34118569
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Sun, LL
   Wang, ZL
   Xu, TD
   Pan, DF
   Liang, L
   Hao, J
   Wang, XP
   Li, DY
AF Sun, Lulu
   Wang, Zilong
   Xu, Tongda
   Pan, Defeng
   Liang, Li
   Hao, Ji
   Wang, Xiaoping
   Li, Dongye
TI The value of real-time myocardial contrast echocardiography for
   detecting coronary microcirculation function in coronary artery disease
   patients
SO ANATOLIAN JOURNAL OF CARDIOLOGY
LA English
DT Article
DE real-time myocardial contrast echocardiography; coronary angiography;
   coronary microcirculation function
ID CARDIAC SYNDROME-X; BLOOD-FLOW; MICROVASCULAR DYSFUNCTION; DOBUTAMINE
   STRESS; ANGINA-PECTORIS; STABLE ANGINA; INFARCTION; QUANTIFICATION;
   RESERVE; REPERFUSION
AB Objective: The aim of this study was to evaluate the value of real-time myocardial contrast echocardiography (RT-MCE) for detecting coronary microcirculation (CM) function in coronary artery disease (CAD) patients.
   Methods: Sixty-five consecutive patients were divided into CAD (n=52) and no-CAD (n=13) groups using coronary angiography (CAG). All patients underwent RT-MCE at rest and CAG within 1 week after RT-MCE. The ventricular segments in CAD patients were divided semi-quantitatively into ischemic and non-ischemic myocardial groups based on RT-MCE images. Myocardial blood volume (A), myocardial blood flow velocity (beta), and mean myocardial blood flow (A x beta) were obtained. The Gensini scores were calculated for CAD patients. The receiver operating characteristic (ROC) curve areas of A, beta, and A x beta were calculated to assess CM function in CAD patients.
   Results: A total of 798 and 204 segments were investigated in the CAD and non-CAD groups, respectively. In CAD patients, 332 ischemic and 466 non-ischemic segments were identified. The values of A, beta, and A x beta were significantly different among non-CAD, CAD, ischemic, and nonischemic groups. ROC curve areas of A, beta, and A x beta were 0.85, 0.79, and 0.83, respectively, and significant differences were observed in these values among three Gensini score groups of the CAD patients.
   Conclusion: Varying degrees of CM function deterioration was observed in CAD patients both in ischemic and non-ischemic areas, with the deterioration being more sever in the former.
C1 [Sun, Lulu; Liang, Li; Hao, Ji; Li, Dongye] Xuzhou Med Univ, Inst Cardiovasc Dis Res, Xuzhou, Jiangsu, Peoples R China.
   [Xu, Tongda; Pan, Defeng; Wang, Xiaoping] Xuzhou Med Univ, Affiliated Hosp, Dept Cardiol, Xuzhou, Jiangsu, Peoples R China.
   [Wang, Zilong] Fudan Univ, Affiliated Zhongshan Hosp, Qingpu Branch, Dept Cardiol, Shanghai, Peoples R China.
C3 Xuzhou Medical University; Xuzhou Medical University; Fudan University
RP Li, DY (corresponding author), Xuzhou Med Univ, Inst Cardiovasc Dis Res, Xuzhou, Jiangsu, Peoples R China.
EM dongyeli@xzhmu.edu.cn
RI Wang, Xiaoping/D-1907-2011; Liang, Li/LKL-2279-2024; Sun,
   Lulu/LKJ-1695-2024; 李, 东野/AAY-6410-2020; Wang, Zilong/IQV-2260-2023
OI Liang, Li/0000-0002-4509-4288
FU Jiangsu Clinical Medicine Science and Technology Projects [BL2013009];
   Jiangsu Postgraduate Innovation Pro-ject [SJLX15-0721]
FX Jiangsu Clinical Medicine Science and Technology Projects (Grant No.
   BL2013009); Jiangsu Postgraduate Innovation Pro-ject (Grant No.
   SJLX15-0721).
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NR 39
TC 4
Z9 12
U1 0
U2 13
PU TURKISH SOC CARDIOLOGY
PI BAHCELIEVLER
PA COBANCESME SANAYI CAD NO 11, NISH ISTANBUL A BLOK KAT 8 NO 47-48,
   YENIBOSNA, BAHCELIEVLER, ISTANBUL 34196, TURKEY
SN 2149-2263
EI 2149-2271
J9 ANATOL J CARDIOL
JI Anat. J. Cardiol.
PD JAN
PY 2018
VL 19
IS 1
BP 27
EP 33
AR PMID 29339697
DI 10.14744/AnatolJCardiol.2017.8041
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA FW3SG
UT WOS:000425229200007
PM 29339697
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Goodman, J
   Kirwan, L
AF Goodman, J
   Kirwan, L
TI Exercise-induced myocardial ischaemia in women - Factors affecting
   prevalence
SO SPORTS MEDICINE
LA English
DT Article
ID CORONARY-ARTERY-DISEASE; GENDER-RELATED DIFFERENCES; HORMONE REPLACEMENT
   THERAPY; LEFT-VENTRICULAR FUNCTION; TERM-FOLLOW-UP; SEX-DIFFERENCES;
   CARDIOVASCULAR-DISEASE; HEART-DISEASE; CHEST-PAIN; CLINICAL
   CHARACTERISTICS
AB Coronary artery disease (CAD) is a major health care challenge, and is the leading cause of death amongst women. Both the delay in the clinical manifestations of CAD and 'atypical' symptomatology in women complicates both diagnosis and treatment strategies in this population. It appears that the age-adjusted prevalence of all-cause angina (effort, unstable, etc.) appears to be greater in women than men, although stenotic lesions are demonstrated less frequently. There are a number of factors that complicates the diagnosis and identification of CAD in women, including more diffuse anginal symptoms, a lower initial detection rate of myocardial ischemia by traditional methods, lower rates of interventional procedures, and lastly, potential differences in the pathophysiology of myocardial ischemia, The lower sensitivity and specificity of many diagnostic techniques including ECG and various imaging technologies contributes significantly to these findings. The increased presence of syndrome X in post-menopausal women may reflect an increased likelihood of microcirculatory disease, where the 'gold standard' angiography fails to detect the presence of disease. Thus nonepicardial coronary stenotic disease may be largely undetected by most studies, rendering many positive ECG stress results unverifiable. The increased co-morbidity seen with CAD in women further complicates diagnosis and interventional results. Combined, these factors act to falsely lower the post-test likelihood of disease in women, adding to the existing gender bias in the diagnosis and referral rates for treatment of CAD in women. The lower precision of disease detection in women contributes to the perception that women have less exertional angina than men, despite evidence to the contrary.
C1 Univ Toronto, Fac Phys Educ & Hlth, Toronto, ON M5S 2W6, Canada.
C3 University of Toronto
RP Univ Toronto, Fac Phys Educ & Hlth, 55 Harbord St, Toronto, ON M5S 2W6, Canada.
RI Goodman, Jack/C-4607-2015
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NR 91
TC 11
Z9 13
U1 0
U2 2
PU ADIS INT LTD
PI NORTHCOTE
PA 5 THE WAREHOUSE WAY, NORTHCOTE 0627, AUCKLAND, NEW ZEALAND
SN 0112-1642
EI 1179-2035
J9 SPORTS MED
JI Sports Med.
PY 2001
VL 31
IS 4
BP 235
EP 247
DI 10.2165/00007256-200131040-00001
PG 13
WC Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Sport Sciences
GA 420UV
UT WOS:000168024400001
PM 11310546
DA 2025-06-11
ER

PT J
AU D'Andrea, A
   Nistri, S
   Castaldo, F
   Galderisi, M
   Mele, D
   Agricola, E
   Losi, MA
   Mondillo, S
   Marino, PN
AF D'Andrea, Antonello
   Nistri, Stefano
   Castaldo, Francesca
   Galderisi, Maurizio
   Mele, Donato
   Agricola, Eustachio
   Losi, Maria Angela
   Mondillo, Sergio
   Marino, Paolo Nicola
CA Italian Soc Cardiol
TI The relationship between early left ventricular myocardial alterations
   and reduced coronary flow reserve in non-insulin-dependent diabetic
   patients with microvascular angina
SO INTERNATIONAL JOURNAL OF CARDIOLOGY
LA English
DT Article
DE Diabetes mellitus; Two-dimensional strain imaging; Tissue Doppler;
   Coronary flow reserve; Microvascular angina
ID SPECKLE TRACKING ECHOCARDIOGRAPHY; TISSUE DOPPLER-ECHOCARDIOGRAPHY;
   CONGESTIVE-HEART-FAILURE; ARTERY-DISEASE; SYNDROME-X; CARDIOMYOPATHY;
   DYSFUNCTION; MELLITUS; STRAIN; ADULTS
AB Aims: To evaluate left ventricular (LV) systolic and diastolic myocardial function, and their relation to coronary flow reserve in patients with non-insulin-dependent diabetes mellitus (DM) and microvascular angina.
   Methods and results: We selected a population of 45 normotensive patients with DM (56.3 +/- 8.2 years; 25 males) with LV ejection fraction >50% and microvascular angina (anginal pain, positive imaging stress test and normal coronary angiography). Thirty-five age-and sex-matched healthy controls were also enrolled. All the patients underwent standard echocardiography, Tissue Doppler (TDI), two-dimensional strain (2DSE) imaging, and coronary flow reserve (CFR) measurement. LV myocardial early diastolic peak velocities (Em) and peak systolic 2DSE were reduced in both interventricular septum (IVS) and LV lateral wall (p<0.01) in DM, as well as CFR (1.89 +/- 0.7 vs 2.55 +/- 0.56, p<0.0001) compared with controls. By multivariate analysis, the independent determinants of Em were glycated haemoglobin (beta coefficient=-0.36; p<0.01) and age (beta=-0.46, p<0.001), while global longitudinal strain was predicted by glycated haemoglobin (beta=0.48, P<0.001) and by the duration of the disease (beta=0.38, P<0.005). An independent association between LV global longitudinal strain and CFR (beta coefficient=-0.47, p<0.001) in DM patients was also evidenced.
   Conclusions: TDI, 2DSE and CFR are valuable non-invasive and easy-repeatable tools for detecting LV myocardial and coronary function in DM patients with microvascular angina. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
C1 [D'Andrea, Antonello; Castaldo, Francesca] Univ Naples 2, Naples, Italy.
   [Nistri, Stefano] CMSR Veneto Med, Altavilla Vicentina, Italy.
   [Galderisi, Maurizio; Losi, Maria Angela] Univ Naples Federico 2, Naples, Italy.
   [Mele, Donato] Azienda Osped Univ Ferrara, Ferrara, Italy.
   [Agricola, Eustachio] Osped San Raffaele IRCCS, Milan, Italy.
   [Mondillo, Sergio] Univ Siena, I-53100 Siena, Italy.
   [Marino, Paolo Nicola] Univ Piemonte Orientale, Novara, Italy.
C3 Universita della Campania Vanvitelli; University of Naples Federico II;
   University of Ferrara; Arcispedale Sant'Anna; Vita-Salute San Raffaele
   University; IRCCS Ospedale San Raffaele; University of Siena; University
   of Eastern Piedmont Amedeo Avogadro
RP D'Andrea, A (corresponding author), Via G Martucci 35, I-80121 Naples, Italy.
EM antonellodandrea@libero.it
RI Agricola, Eustachio/AAC-2019-2019; Mele, Donato/K-2100-2018; Castaldo,
   Francesca/JHT-8323-2023; MONDILLO, Sergio/Q-9354-2018; Nistri,
   Stefano/K-7056-2016
OI MONDILLO, Sergio/0000-0002-5490-2769; LOSI, Maria
   Angela/0000-0001-9819-0401; Marino, Paolo/0000-0002-8192-412X; Stefano,
   Nistri/0000-0003-4723-6646; MELE, Donato/0000-0002-2823-4090; Agricola,
   Eustachio/0000-0002-4834-2187; Innelli, Pasquale/0000-0002-5364-0349;
   Canciello, Grazia/0000-0002-1546-1737; Galderisi,
   Maurizio/0000-0003-0311-9069; Nistri, Stefano/0000-0003-1511-3449
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Z9 21
U1 0
U2 4
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0167-5273
J9 INT J CARDIOL
JI Int. J. Cardiol.
PD FEB 9
PY 2012
VL 154
IS 3
BP 250
EP 255
DI 10.1016/j.ijcard.2010.09.044
PG 6
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 879GO
UT WOS:000299317900011
PM 21035209
DA 2025-06-11
ER

PT J
AU Pries, AR
   Kuebler, WM
   Habazettl, H
AF Pries, Axel R.
   Kuebler, Wolfgang M.
   Habazettl, Helmut
TI Coronary Microcirculation in Ischemic Heart Disease
SO CURRENT PHARMACEUTICAL DESIGN
LA English
DT Review
DE Microvessels; heterogeneity; angioadaptation; vascular permeability;
   inflammation; leucocyte-endothelium interaction
ID ACUTE MYOCARDIAL-INFARCTION; CARDIAC SYNDROME-X; MICROVASCULAR
   DYSFUNCTION; ARTERY-DISEASE; ENDOTHELIAL GLYCOCALYX; STRUCTURAL
   ADAPTATION; VASCULAR-PERMEABILITY; EUROPEAN-SOCIETY; POSITION PAPER;
   WORKING GROUP
AB Background: Ischemic heart disease has long been considered to be exlusively caused by stenosis or occlusion. However, the coronary microcirculation too may play an important role in ischemic conditions. Also, the crucial role of microvessels in not only regulating blood flow on a local level but also mediating vascular permeability or inflammatory responses has been recognized.
   Objective: To review important physiological and pathophysiological mechanisms of coronary microcirculatory control with focus on heterogeneity of local perfusion, microvascular permeability and inflammation.
   Method: Selective research of the literature.
   Results: Heterogeneity is a characteristic of microvascular networks and affects structural and functional parameters such as vessel diameter, length, and connection pattern, flow velocity, wall shear stress, and oxygenation. Microvascular networks are optimized to meet the metabolic demand of all tissue compartments. This requires continuous vascular adaptation regulated by local hemodynamic and metabolic stimuli. Compromising this regulation results in functional arterio-venous shunting and tissue areas with either hyperperfusion or hypoxia in close proximity. In ischemia-reperfusion, increased microvascular permeability may aggravate tissue hypoxia by increasing extravascular pressure and seems to contribute to adverse myocardial remodeling. Transendothelial transport mechanisms and deterioration of the endothelial glycocalyx seem to be major contributors to tissue edema. Also in the context of ischemia-reperfusion, an inflammatory response mediated by venular endothelium expressing specific adhesion molecules contributes to tissue injury. However, anti-inflammatory therapies failed in clinical studies and a multi-targeted approach for cardiac protection is required.
   Conclusion: Disturbances of the coronary microcirculation are involved in different pathophysiological aspects of reperfusion injury.
C1 [Pries, Axel R.; Kuebler, Wolfgang M.; Habazettl, Helmut] Charite Univ Med Berlin, Berlin, Germany.
   [Pries, Axel R.; Kuebler, Wolfgang M.; Habazettl, Helmut] Free Univ Berlin, Berlin, Germany.
   [Pries, Axel R.; Kuebler, Wolfgang M.; Habazettl, Helmut] Humboldt Univ, Berlin, Germany.
   [Pries, Axel R.; Kuebler, Wolfgang M.; Habazettl, Helmut] Berlin Inst Hlth, Inst Physiol, Berlin, Germany.
   [Pries, Axel R.; Kuebler, Wolfgang M.; Habazettl, Helmut] Deutsch Herzzentrum Berlin, Berlin, Germany.
C3 Berlin Institute of Health; Free University of Berlin; Humboldt
   University of Berlin; Charite Universitatsmedizin Berlin; Free
   University of Berlin; Humboldt University of Berlin; Berlin Institute of
   Health; German Heart Center Berlin
RP Pries, AR (corresponding author), Charite, Dept Physiol, Charitepl 1, D-10117 Berlin, Germany.
EM axel.pries@charite.de
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NR 95
TC 13
Z9 18
U1 0
U2 8
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1381-6128
EI 1873-4286
J9 CURR PHARM DESIGN
JI Curr. Pharm. Design
PY 2018
VL 24
IS 25
BP 2893
EP 2899
DI 10.2174/1381612824666180625142341
PG 7
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA HA2MQ
UT WOS:000450073300002
PM 29938611
DA 2025-06-11
ER

PT J
AU Jin, ZD
   Liu, MW
   Xie, BL
   Wen, W
   Yan, YX
   Zhang, YF
   Li, HH
   Shen, ZY
   Jiang, LL
   Gao, MJ
   Chen, KJ
   Zhao, FH
AF Jin, Zhidie
   Liu, Mingwang
   Xie, Beili
   Wen, Wei
   Yan, Yuxin
   Zhang, Yangfang
   Li, Haohao
   Shen, ZhengYu
   Jiang, Lulian
   Gao, Mengjie
   Chen, Keji
   Zhao, Fuhai
TI Generation of a medicine food homology formula and its likely mechanism
   in treatment of microvascular angina
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Article
DE medicine food homology; data mining; network pharmacology; molecular
   docking; east asian traditional medicine; microvascular angina; coronary
   microvascular disease; coronary artery disease
ID CYTOMEGALOVIRUS-INFECTION; SYNDROME-X; RISK
AB Microvascular angina (MVA) is the most common cause of cardiac ischemic chest pain in patients without obstructive coronary artery disease (CAD) and lacks of effective treatment means. Medicine food homology (MFH) involves substances with both nutritional and medicinal qualities that have the potential to improve MVA symptoms as medicines, dietary supplements. However, research on MFH formula (MFHF) for MVA is not available. The study aims to generate a core MFHF for MVA through data mining and offer scientific backing for the utilization of edible medications in the prevention and alleviation of MVA. 11 databases were utilized to construct a database of MFH drugs, and the MFHF was generated through frequency analysis, association rule analysis, and clustering analysis. The composition of the formula is Codonopsis Radix, Astragali Radix, Platycodonis Radix, Persicae Semen, Glycyrrhizae Radix Et Rhizoma, Angelicae Sinensis Radix, and Allii Macrostemonis Bulbus. Through network pharmacology and molecular docking, we identified five major active components of MFHF: Adenosine, Nonanoic Acid, Lauric Acid, Caprylic Acid, and Enanthic Acid, along with nine core targets (NFKB1, ALB, AKT1, ACTB, TNF, IL6, ESR1, CASP3, and PTGS) for the improvement of MVA. These 5 active components have various biological activities, such as reducing oxidative stress, anti-inflammation, analgesia effect, inhibiting platelet aggregation, vasodilatation, vascular endothelial protection, and cardio-protection. GO and KEGG enrichment analyses revealed that MFHF mainly acted on the response to xenobiotic stimulus, integrative component of the plasma membrane, RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding, pathways in cancer, lipid and atherosclerosis, human cytomegalovirus infection, and the PI3K-Akt signaling pathway, which are the main pathogenesis of MVA.
C1 [Jin, Zhidie; Liu, Mingwang; Xie, Beili; Wen, Wei; Zhang, Yangfang; Chen, Keji; Zhao, Fuhai] China Acad Chinese Med Sci, Xiyuan Hosp, Beijing, Peoples R China.
   [Yan, Yuxin; Li, Haohao; Jiang, Lulian; Gao, Mengjie] Univ Chinese Med, Grad Sch Beijing, Beijing, Peoples R China.
   [Shen, ZhengYu] Shanxi Univ Tradit Chinese Med, Affiliated Hosp, Taiyuan, Peoples R China.
C3 Xiyuan Hospital, CACMS; China Academy of Chinese Medical Sciences
RP Zhao, FH (corresponding author), China Acad Chinese Med Sci, Xiyuan Hosp, Beijing, Peoples R China.
EM 13911134962@163.com
RI Yan, Yuxin/LKM-6764-2024; SHEN, ZHENGYU/IQV-5892-2023
FU Science and Technology Innovation Project of the China Academy of
   Chinese Medical Sciences [CI 2021A00901]
FX The author(s) declare that financial support was received for the
   research, authorship, and/or publication of this article. This work was
   supported by a grant from the Science and Technology Innovation Project
   of the China Academy of Chinese Medical Sciences (No. CI 2021A00901).
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NR 61
TC 0
Z9 0
U1 6
U2 12
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD AUG 30
PY 2024
VL 15
AR 1404874
DI 10.3389/fphar.2024.1404874
PG 16
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA F5R1A
UT WOS:001310378200001
PM 39281275
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Cenko, E
   Bugiardini, R
AF Cenko, Edina
   Bugiardini, Raffaele
TI Barriers to Risk Stratification Accuracy in Ischemic Heart Disease in
   Women: The Role of Non-Obstructive Coronary Artery Disease
SO CURRENT PHARMACEUTICAL DESIGN
LA English
DT Review
DE Women; chest pain; nonobstructive CAD; angina with normal angiography;
   risk stratification; ischemic heart disease
ID EMISSION COMPUTED-TOMOGRAPHY; ACUTE MYOCARDIAL-INFARCTION; SYNDROME
   EVALUATION WISE; DOBUTAMINE STRESS ECHOCARDIOGRAPHY; LEFT-VENTRICULAR
   FUNCTION; FRACTIONAL FLOW RESERVE; STABLE ANGINA-PECTORIS; CARDIAC
   SYNDROME-X; CHEST-PAIN; SEX-DIFFERENCES
AB Background: A substantial part of literature has been centered on sex differences in the clinical aspects of ischemic heart disease (IHD). Many reports have documented differences in the presentation and risk profile between women and men. Such differences drive sex-related inequalities in the referral and treatment of IHD. Yet data are insufficient to clarify the reasons for such disparities. The objective of this review is to analyze the main gender differences regarding symptoms, diagnosis, and risk stratification of coronary heart disease in order to identify "gaps" in existing literature that need to be addressed in future research efforts. Methods: We searched English-language studies on MEDLINE and the Cochrane Database of Systematic Reviews from the database start dates to January 2016. Evidence synthesis was based on cohort studies, registry data, and clinical trial data. Results: Women do not often participate in clinical studies. In a number of articles, authors have questioned how the "white male" came to be the prototype of the human research subject. Consequently although many reports continue to describe differential treatment based on patients' sex, the extent to which such inequalities are due to true sex differences in pathophysiology or whether they reflects inaccuracy in risk stratification is unclear. Conclusion: Today, even the best database is incapable in and of itself of supplying answers to the question of whether women are being treated less compared with men by the medical community.
C1 [Cenko, Edina; Bugiardini, Raffaele] Univ Bologna, Dept Expt Diagnost & Specialty Med, Via Massarenti 9,Padigl 11, I-40138 Bologna, Italy.
C3 University of Bologna
RP Cenko, E (corresponding author), Univ Bologna, Dept Expt Diagnost & Specialty Med, Via Massarenti 9,Padigl 11, I-40138 Bologna, Italy.
EM edina.cenko2@unibo.it
RI Cenko, Edina/L-6438-2015; Bugiardini, Raffaele/L-6446-2015
OI Cenko, Edina/0000-0001-8102-3324; Bugiardini,
   Raffaele/0000-0002-6819-6818
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NR 83
TC 5
Z9 5
U1 0
U2 4
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1381-6128
EI 1873-4286
J9 CURR PHARM DESIGN
JI Curr. Pharm. Design
PY 2016
VL 22
IS 25
BP 3928
EP 3934
DI 10.2174/1381612822666160311115344
PG 7
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA DX9OV
UT WOS:000384725900015
PM 26965490
DA 2025-06-11
ER

PT J
AU Chen, L
   Lei, B
   Lou, Y
   Chen, LX
   Jiang, JQ
AF Chen, Liang
   Lei, Bei
   Lou, Ying
   Chen, Lixiu
   Jiang, Jinqi
TI Impact of intravenous administration of anisodamine on coronary
   microvascular dysfunction in patients with obstructive epicardial
   coronary artery disease after percutaneous coronary intervention
SO TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH
LA English
DT Article
DE Coronary microvascular dysfunction; Coronary artery disease;
   Percutaneous coronary; intervention; Anisodamine; Intravenous
   administration
ID HEART-DISEASE; SYNDROME-X; UPDATE
AB Purpose: To analyze intravenous administration of anisodamine's impact on coronary microvascular dysfunction (CMD) in obstructive epicardial coronary artery disease (CAD) patients who had undergone percutaneous coronary intervention (PCI). Methods: Enrollment of 210 patients in Shanghai Chest Hospital, Shanghai Jiaotong University with CMD was done in a randomized-controlled study. They were divided randomly into groups, viz, anisodamine (A) group and nitrate (N) group. A 14-day course of treatment was carried out in each group. 99mTc-MIBI myocardial perfusion imaging (MPI), treadmill exercise test (TET) and two-dimensional echocardiography (TDE) were performed, and the symptoms of angina pectoris were recorded before and after treatment according to the classification, frequency, and duration of angina, as defined by Canadian Cardiovascular Society (CCS). Results: After treatment, summed stress score (SSS) and summed rest score (SRS) of MPI in group A significantly decreased after treatment (p < 0.001, respectively) and were remarkably lower than those in group N (p < 0.001, respectively). The CCS class in group A improved after treatment (p < 0.001) and was also better than in group N (p < 0.001). The frequency and duration of angina attack in group A significantly reduced after treatment (p < 0.001, respectively) and were notably lower than in group N (p < 0.001, respectively). Left ventricular ejection fraction in group A after treatment was higher than that before treatment (p = 0.046) and than that in group N (p = 0.048). Furthermore, the side effects of anisodamine were slight and tolerable. Conclusion: Intravenous administration of anisodamine is a potentially suitable optional treatment for CMD in patients with obstructive epicardial CAD who have undergone PCI.
C1 [Chen, Liang; Lou, Ying; Jiang, Jinqi] Shanghai Jiao Tong Univ, Shanghai Chest Hosp, Dept Emergency, Shanghai 200030, Peoples R China.
   [Lei, Bei] Shanghai Jiao Tong Univ, Shanghai Chest Hosp, Dept Nucl Med, Shanghai 200030, Peoples R China.
   [Chen, Lixiu] Shanghai Jiao Tong Univ, Shanghai Chest Hosp, Cardiac Funct Room, Shanghai 200030, Peoples R China.
C3 Shanghai Jiao Tong University; Shanghai Jiao Tong University; Shanghai
   Jiao Tong University
RP Jiang, JQ (corresponding author), Shanghai Jiao Tong Univ, Shanghai Chest Hosp, Dept Emergency, Shanghai 200030, Peoples R China.
EM jiangjinq2020@163.com
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NR 22
TC 3
Z9 3
U1 0
U2 9
PU PHARMACOTHERAPY GROUP
PI BENIN CITY
PA UNIV BENIN, FACULTY PHARMACY, BENIN CITY, 00000, NIGERIA
SN 1596-5996
J9 TROP J PHARM RES
JI Trop. J. Pharm. Res.
PD MAY
PY 2022
VL 21
IS 5
BP 1045
EP 1053
DI 10.4314/tjpr.v21i5.19
PG 9
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 1Y3VJ
UT WOS:000808070700002
OA gold
DA 2025-06-11
ER

PT J
AU Frisbee, JC
AF Frisbee, JC
TI Impaired skeletal muscle perfusion in obese Zucker rats
SO AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE
   PHYSIOLOGY
LA English
DT Article
DE skeletal muscle microcirculation; skeletal muscle fatigue; obesity;
   models of syndrome X
ID SPONTANEOUSLY HYPERTENSIVE RATS; OXIDANT STRESS; IN-VIVO; CONTRACTILE
   CHARACTERISTICS; MICROVASCULAR RAREFACTION; RESISTANCE ARTERIES;
   INSULIN-RESISTANT; DIABETIC RATS; CAPILLARIZATION; DILATION
AB Skeletal muscle arterioles from obese Zucker rats (OZR) exhibit oxidant stressbased alterations in reactivity, enhanced alpha-adrenergic constriction, and reduced distensibility vs. microvessels of lean Zucker rats (LZR). The present study determined the impact of these alterations for perfusion and performance of in situ skeletal muscle during periods of elevated metabolic demand. During bouts of isometric tetanic contractions, fatigue of in situ gastrocnemius muscle of OZR was increased vs. LZR; this was associated with impaired active hyperemia. In OZR, vasoactive responses of skeletal muscle arterioles from the contralateral gracilis muscle were impaired, due in part to elevated oxidant tone; reactivity was improved after treatment with polyethylene glycol-superoxide dismutase (PEG-SOD). Arterioles of OZR also exhibited increased alpha-adrenergic sensitivity, which was abolished by treatment with phentolamine ( 10(-5) M). Intravenous infusion of phentolamine ( 10 mg/kg) or PEG-SOD ( 2,000 U/kg) in OZR altered neither fatigue rates nor active hyperemia from untreated levels; however, combined infusion improved performance and hyperemia, although not to levels in LZR. Microvessel density in the contralateral gastrocnemius muscle, determined via histological analyses, was reduced by similar to 25% in OZR vs. LZR, while individual arterioles from the contralateral gracilis muscle demonstrated reduced distensibility. These data suggest that altered arteriolar reactivity contributes to reduced muscle performance and active hyperemia in OZR. Further, despite pharmacological improvements in arteriolar reactivity, reduced skeletal muscle microvessel density and arteriolar distensibility also contribute substantially to reduced active hyperemia and potentially to impaired muscle performance.
C1 Med Coll Wisconsin, Dept Physiol, Milwaukee, WI 53226 USA.
C3 Medical College of Wisconsin
RP Frisbee, JC (corresponding author), Med Coll Wisconsin, Dept Physiol, 8701 Watertown Plank Rd, Milwaukee, WI 53226 USA.
OI Frisbee, Jefferson/0000-0003-2751-0599
FU NHLBI NIH HHS [HL-29587, HL-65289] Funding Source: Medline
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NR 39
TC 60
Z9 70
U1 0
U2 0
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0363-6119
J9 AM J PHYSIOL-REG I
JI Am. J. Physiol.-Regul. Integr. Comp. Physiol.
PD NOV 1
PY 2003
VL 285
IS 5
BP R1124
EP R1134
DI 10.1152/ajpregu.00239.2003
PG 11
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA 731VY
UT WOS:000185908200027
PM 12855417
DA 2025-06-11
ER

PT J
AU Siegrist, PT
   Husmann, L
   Knabenhans, M
   Gaemperli, O
   Valenta, I
   Hoefflinghaus, T
   Scheffel, H
   Stolzmann, P
   Alkadhi, H
   Kaufmann, PA
AF Siegrist, Patrick T.
   Husmann, Lars
   Knabenhans, Martina
   Gaemperli, Oliver
   Valenta, Ines
   Hoefflinghaus, Tobias
   Scheffel, Hans
   Stolzmann, Paul
   Alkadhi, Hatem
   Kaufmann, Philipp A.
TI <SUP>13</SUP>N-ammonia myocardial perfusion imaging with a PET/CT
   scanner:: impact on clinical decision making and cost-effectiveness
SO EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
LA English
DT Article
DE N-13-ammonia myocardial perfusion imaging; impact on patient management;
   clinical decision making; cost-effectiveness; positron emission
   tomography
ID CORONARY-ARTERY-DISEASE; POSITRON-EMISSION-TOMOGRAPHY; BLOOD-FLOW; N-13
   AMMONIA; NONINVASIVE QUANTIFICATION; COMPUTED-TOMOGRAPHY; SYNDROME-X;
   STRESS; EXERCISE; RESERVE
AB Purpose The purpose of the study is to determine the impact of N-13-ammonia positron emission tomography ( PET) myocardial perfusion imaging ( MPI) on clinical decision making and its cost- effectiveness.
   Materials and methods One hundred consecutive patients ( 28 women, 72 men; mean age 60.9 +/- 12.0 years; range 24 85 years) underwent N-13- ammonia PET scanning ( and computed tomography, used only for attenuation correction) to assess myocardial perfusion in patients with known ( n= 79) or suspected ( n= 8) coronary artery disease ( CAD), or for suspected small-vessel disease ( SVD; n= 13). Before PET, the referring physician was asked to determine patient treatment if PET would not be available. Four weeks later, PET patient management was reassessed for each patient individually.
   Results Before PET management strategies would have been: diagnostic angiography ( 62 of 100 patients), diagnostic angiography and percutaneous coronary intervention ( PCI; 6 of 100), coronary artery bypass grafting ( CABG; 3 of 100), transplantation ( 1 of 100), or conservative medical treatment ( 28 of 100). After PET scanning, treatment strategies were altered in 78 patients leading to: diagnostic angiography ( 0 of 100), PCI ( 20 of 100), CABG ( 3 of 100), transplantation ( 1 of 100), or conservative medical treatment ( 76 of 100). Patient management followed the recommendations of PET findings in 97% of the cases. Cost-effectiveness analysis revealed lower costs of epsilon 206/ patient as a result of PET scanning.
   Conclusion In a population with a high prevalence of known CAD, PET is cost-effective and has an important impact on patient management.
C1 [Siegrist, Patrick T.; Husmann, Lars; Knabenhans, Martina; Gaemperli, Oliver; Valenta, Ines; Kaufmann, Philipp A.] Univ Zurich Hosp, Ctr Cardiovasc, CH-8091 Zurich, Switzerland.
   [Scheffel, Hans; Stolzmann, Paul; Alkadhi, Hatem] Univ Zurich Hosp, Inst Diagnost Radiol, CH-8091 Zurich, Switzerland.
   [Kaufmann, Philipp A.] Ctr Integrat Human Physiol, Zurich, Switzerland.
C3 University of Zurich; University Zurich Hospital; University of Zurich;
   University Zurich Hospital; University of Zurich; Zurich Center
   Integrative Human Physiology (ZIHP)
RP Kaufmann, PA (corresponding author), Univ Zurich Hosp, Ctr Cardiovasc, CH-8091 Zurich, Switzerland.
EM pak@usz.ch
OI Kaufmann, Philipp Antonio/0000-0002-9451-5210; Alkadhi,
   Hatem/0000-0002-2581-2166
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NR 29
TC 34
Z9 35
U1 0
U2 3
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1619-7070
EI 1619-7089
J9 EUR J NUCL MED MOL I
JI Eur. J. Nucl. Med. Mol. Imaging
PD MAY
PY 2008
VL 35
IS 5
BP 889
EP 895
DI 10.1007/s00259-007-0647-3
PG 7
WC Radiology, Nuclear Medicine & Medical Imaging
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Radiology, Nuclear Medicine & Medical Imaging
GA 287FP
UT WOS:000254902700002
PM 18057933
DA 2025-06-11
ER

PT J
AU Lutfi, MF
AF Lutfi, Mohamed Faisal
TI Diagnostic accuracy of resting left ventricular akinesia/hypokinesia in
   predicting abnormal coronary angiography
SO BMC CARDIOVASCULAR DISORDERS
LA English
DT Article
DE Akinesia/hypokinesia; Coronary artery disease; Coronary angiography;
   Ejection fraction
ID EJECTION FRACTION; ARTERY-DISEASE; HEART-FAILURE; SYNDROME-X;
   SPECIFICITY; SENSITIVITY
AB Background: Although several reports demonstrate the efficacy of stress echocardiography in diagnosing coronary artery disease, comparable studies on the competence of the same imaging technique at rest are limited. This study aimed to evaluate whether ventricular akinesia/hypokinesia and left ventricular ejection fraction (LVEF) < 55 % at rest are useful in predicting abnormal coronary angiography.
   Methods: This study prospectively enrolled 100 diagnostic coronary catheterization candidates. Any routine echocardiography that the candidates had undergone before diagnostic coronary catheterization was reviewed. Patients were subclassified according to the presence and location of ventricular akinesia/hypokinesia, LVEF, and the results of diagnostic coronary catheterization. LVEF < 55 % was considered below the normal physiological limit. Abnormal coronary angiography was defined as narrowing of half or more of the caliber of at least one major coronary artery.
   Results: Abnormal coronary angiography was significantly associated with akinesia/hypokinesia (OR = 4.85, P = 0.002) and LVEF < 55 % (OR = 5.75, P = 0.001). Screening of akinesia/hypokinesia and LVEF < 55 % as diagnostic tools for abnormal coronary angiography achieved comparable sensitivities (87.2 % vs. 88.9 %), specificities (41.5 vs. 41.8), and diagnostic accuracies (41.5 vs. 41.8). Left ventricular anterior wall akinesia/hypokinesia achieved a higher diagnostic odds ratio (9.7), sensitivity (95 %), and negative predictive value (96.4 %) compared with other types of akinesia/hypokinesia.
   Conclusion: The overall diagnostic accuracy of akinesia/hypokinesia and LVEF < 55 % to predict abnormal coronary angiography was poor, probably owing to significant influences of macro-as well as micro-vascular ischemia on left ventricular function.
C1 [Lutfi, Mohamed Faisal] Al Neelain Univ, Dept Physiol, Fac Med & Hlth Sci, Mailbox 12702, Khartoum 11121, Sudan.
RP Lutfi, MF (corresponding author), Al Neelain Univ, Dept Physiol, Fac Med & Hlth Sci, Mailbox 12702, Khartoum 11121, Sudan.
EM mohamedfaisallutfi@gmail.com
RI Lutfi, Mohamed/LTF-3068-2024
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NR 23
TC 2
Z9 2
U1 0
U2 0
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1471-2261
J9 BMC CARDIOVASC DISOR
JI BMC Cardiovasc. Disord.
PD JUN 13
PY 2016
VL 16
AR 137
DI 10.1186/s12872-016-0312-5
PG 6
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA DO2XW
UT WOS:000377645400002
PM 27295983
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Venu, L
   Harishankar, N
   Krishna, TP
   Raghunath, M
AF Venu, L
   Harishankar, N
   Krishna, TP
   Raghunath, M
TI Does maternal dietary mineral restriction per se predispose the
   offspring to insulin resistance?
SO EUROPEAN JOURNAL OF ENDOCRINOLOGY
LA English
DT Article
ID BLOOD-PRESSURE; BIRTH-WEIGHT; GLUCOSE-TOLERANCE; ADULT-RATS; SYNDROME-X;
   FAT-CELLS; PROTEIN; GROWTH; NUTRITION; LEADS
AB Background: Maternal undernutrition is hypothesized to predispose the offspring to disease in adult life. The relevance of maternal macronutrient deficiency has been well studied but not that of micronutrients.
   Objective: To assess the effect of maternal dietary mineral restriction per se on oral glucose tolerance (OGT). insulin resistance (IR) and fat metabolism in offspring.
   Design: Female weanling Wistar/NIN rats received a control or a 50% mineral-restricted (MR) diet for 12 weeks, by which time MR rats had lower plasma Fe, Zn, Mg and Ca concentrations. Following mating with control males, a third of the MR dams were shifted to the control diet from parturition. Half of the pups born to the remaining MR dams were weaned onto the control diet while the other half continued on the MR diet.
   Results: Pregnant MR dams had a higher abortion rate, body weights of their pups at birth and weaning were lower and rehabilitation had no beneficial effect. No offspring had impaired OGT and IR status was comparable among different groups on postnatal days 40, 70, 100 or 180. Compared with controls, total body electrical conductivity measurements indicated significantly higher body fat %. lower lean body mass and fat-free mass in MR offspring besides elevated plasma triacylglycerols. Mineral rehabilitation from parturition or weaning had little effect on these changes, which did not appear to be due to increased oxidative stress.
   Conclusions: Maternal MR per se resulted in an increase in body fat and in plasma triacylglycerol concentrations in the offspring. These changes had, however, no discernable effect on insulin sensitivity over the first 180 days of life.
C1 Natl Inst Nutr, ICMR, Div Endocrinol & Metab, Hyderabad 500007, Andhra Pradesh, India.
   Natl Inst Nutr, ICMR, Div Stat, Hyderabad 500007, Andhra Pradesh, India.
   Natl Inst Nutr, ICMR, Natl Ctr Lab Anim Sci, Hyderabad 500007, Andhra Pradesh, India.
C3 Indian Council of Medical Research (ICMR); ICMR - National Institute of
   Nutrition (NIN); Indian Council of Medical Research (ICMR); ICMR -
   National Institute of Nutrition (NIN); Indian Council of Medical
   Research (ICMR); ICMR - National Institute of Nutrition (NIN); ICMR -
   National Animal Resource Facility for Biomedical Research (NARFBR)
RP Natl Inst Nutr, ICMR, Div Endocrinol & Metab, Hyderabad 500007, Andhra Pradesh, India.
EM manchalar@yahoo.com
RI Lagishetty, Venu/C-8251-2009
OI Lagishetty, Venu/0000-0001-6500-8255
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NR 44
TC 28
Z9 31
U1 0
U2 1
PU BIOSCIENTIFICA LTD
PI BRISTOL
PA STARLING HOUSE, 1600 BRISTOL PARKWAY N, BRISTOL, ENGLAND
SN 0804-4643
EI 1479-683X
J9 EUR J ENDOCRINOL
JI Eur. J. Endocrinol.
PD AUG
PY 2004
VL 151
IS 2
BP 287
EP 294
DI 10.1530/eje.0.1510287
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 850PD
UT WOS:000223624000019
PM 15296486
OA Bronze
DA 2025-06-11
ER

PT J
AU Lawson, MA
   Bell, SP
   WAdkisson, D
   Wang, L
   Ooi, H
   Sawyer, DB
   Kronenberg, MW
AF Lawson, Mark A.
   Bell, Susan P.
   WAdkisson, Douglas
   Wang, Li
   Ooi, Henry
   Sawyer, Douglas B.
   Kronenberg, Marvin W.
TI High reproducibility of adenosine stress cardiac MR myocardial perfusion
   imaging in patients with non-ischaemic dilated cardiomyopathy
SO BMJ OPEN
LA English
DT Article
ID CARDIOVASCULAR MAGNETIC-RESONANCE; CORONARY-ARTERY-DISEASE; EMISSION
   COMPUTED-TOMOGRAPHY; CONGESTIVE-HEART-FAILURE; INTERSTUDY
   REPRODUCIBILITY; SUBENDOCARDIAL PERFUSION; FAILING HEART; SYNDROME-X;
   RESERVE; TRIAL
AB Objective: To evaluate the reproducibility of first-pass contrast-enhanced cardiac MR (CMR) myocardial perfusion imaging in patients with non-ischaemic dilated cardiomyopathy (NIDCM).
   Design: Prospective observational study.
   Setting: Single centre, tertiary care hospital.
   Participants: 6 outpatient participants with NIDCM.
   Outcome: Reproducibility of semiquantitative myocardial perfusion analysis by CMR.
   Method: 6 patients with NIDCM were studied twice using first-pass of contrast transit through the left ventricular (LV) myocardium with a saturation-recovery gradient echo sequence at rest and during adenosine-induced hyperaemia. The anterior wall was divided into endocardial (Endo) and epicardial (Epi) segments. The Myocardial Perfusion Index (MPI) was calculated as the myocardial signal augmentation rate normalised to the LV cavity rate. The Myocardial Perfusion Reserve Index (MPRI) was calculated as hyperaemic/resting MPI.
   Results: Between study 1 and 2, median MPI was similar for resting Endo (0.076 vs 0.077), hyperaemic Endo (0.143 vs 0.143), resting Epi (0.073 vs 0.074), and hyperaemic Epi (0.135 vs 0.134). Median MPRI was similar for Endo (1.84 vs 1.87) and Epi (1.90 vs 2.00). Combining Endo and Epi MPI (N=12), there was excellent agreement between Study 1 and 2 for resting MPI (r=0.998, intraclass correlation coefficient (ICC) 0.998, coefficients of variation (CoV) 1.4%), hyperaemic MPI (r=0.979, ICC 0.963, CoV 3.3%) and MPRI (r=0.989, ICC 0.94, CoV 3.8%).
   Conclusions: Resting and hyperaemic myocardial perfusion using a normalised upslope analysis during adenosine CMR is a highly reproducible technique in patients with NIDCM.
C1 [Lawson, Mark A.; Bell, Susan P.; WAdkisson, Douglas; Ooi, Henry; Sawyer, Douglas B.; Kronenberg, Marvin W.] Vanderbilt Univ, Sch Med, Div Cardiovasc Med, Nashville, TN 37212 USA.
   [Wang, Li] Vanderbilt Univ, Med Ctr, Dept Biostat, Nashville, TN USA.
   [Ooi, Henry; Kronenberg, Marvin W.] Tennessee Valley Healthcare Syst, Dept Vet Affairs, Cardiol Sect, Nashville, TN USA.
C3 Vanderbilt University; Vanderbilt University; US Department of Veterans
   Affairs; Veterans Health Administration (VHA); VA Tennessee Valley
   Healthcare System
RP Kronenberg, MW (corresponding author), Vanderbilt Univ, Sch Med, Div Cardiovasc Med, Nashville, TN 37212 USA.
EM marvin.w.kronenberg@vanderbilt.edu
OI Sawyer, Douglas/0009-0006-7584-0700
FU Vanderbilt University Medical Center; Vanderbilt CTSA [UL1RR024975
   NCRR/NIH]; NIH [T32 HL 07411-31]; Clinical and Translational Science
   Award [UL1RR024975 NCRR/NIH]; NIH (Bethesda, MD USA) [T32 HL 07411-31]
FX This study was supported in part by a Discovery Grant from the
   Vanderbilt University Medical Center and by the Vanderbilt CTSA grant
   UL1RR024975 NCRR/NIH. Drs Adkisson and Bell were supported by NIH
   Training Grant T32 HL 07411-31. The contents are solely the
   responsibility of the authors and do not necessarily represent official
   views of the National Center for Advancing Translational Sciences or the
   National Institutes of Health. This study was supported in part by
   Clinical and Translational Science Award UL1RR024975 NCRR/NIH, and Drs
   Adkisson and Bell were supported by NIH Training Grant T32 HL 07411-31
   (Bethesda, MD USA).
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NR 23
TC 5
Z9 5
U1 0
U2 0
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2044-6055
J9 BMJ OPEN
JI BMJ Open
PY 2014
VL 4
IS 12
AR e005984
DI 10.1136/bmjopen-2014-005984
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA CJ3WC
UT WOS:000355413900030
PM 25515841
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Forde, SA
   Coppinger, T
   Rea, S
   Hanrahan, S
AF Forde, Shannon Aisling
   Coppinger, Tara
   Rea, Susan
   Hanrahan, Sinead
TI The effectiveness of digital tools in physical activity interventions
   for individuals with severe mental illness: a scoping review
SO DISABILITY AND REHABILITATION-ASSISTIVE TECHNOLOGY
LA English
DT Review; Early Access
DE Severe mental illness; enduring mental illness; serious mental illness;
   physical activity; digital tool; digital technology; physical activity
   intervention
ID BEHAVIORAL WEIGHT-LOSS; METABOLIC SYNDROME; SEDENTARY BEHAVIOR; WEARABLE
   DEVICES; SCHIZOPHRENIA; PEOPLE; EXERCISE; PROGRAM; ADULTS; FEASIBILITY
AB PurposeSevere mental illness (SMI) encompasses a mental, behavioural, or emotional disorder resulting in serious functional impairment, which substantially interferes with or limits an individual's life activities. SMI can include disorders such as personality, psychotic, bipolar and major depression. Incorporating physical activity (PA) into the daily lives of individuals with SMI offers increasing health benefits. Despite the acknowledged benefits of PA, there are barriers to engagement and participation rates remain low. Digital tools in PA interventions are rapidly increasing amongst this cohort and can mitigate these barriers. However, the broader implications of how a digital PA intervention can impact this cohort and act as a long-term solution are often overlooked.Materials and Methods: Seven databases were searched. A search string was developed around three categories: Enduring Mental Illness, Digital Tools, and Physical Activity. Full-text screening was performed, and quality checks were completed. Articles selected for review were exported as a list into Microsoft Excel. 24 articles were deemed eligible for inclusion.PurposeSevere mental illness (SMI) encompasses a mental, behavioural, or emotional disorder resulting in serious functional impairment, which substantially interferes with or limits an individual's life activities. SMI can include disorders such as personality, psychotic, bipolar and major depression. Incorporating physical activity (PA) into the daily lives of individuals with SMI offers increasing health benefits. Despite the acknowledged benefits of PA, there are barriers to engagement and participation rates remain low. Digital tools in PA interventions are rapidly increasing amongst this cohort and can mitigate these barriers. However, the broader implications of how a digital PA intervention can impact this cohort and act as a long-term solution are often overlooked.Materials and Methods: Seven databases were searched. A search string was developed around three categories: Enduring Mental Illness, Digital Tools, and Physical Activity. Full-text screening was performed, and quality checks were completed. Articles selected for review were exported as a list into Microsoft Excel. 24 articles were deemed eligible for inclusion.Results14 studies found an increase in PA. Walking was the most common form of PA. The most frequently utilised digital tool was an accelerometer. Group PA was more frequent than individual PA. Many studies used supervision within the intervention. Outcomes varied across studies.Conclusion: Digital PA interventions vary in design and show promise in increasing PA amongst the cohort. However, further research is needed to determine the feasibility and acceptability of digital tools and to incorporate different elements into the design of digital PA interventions, particularly for a long-term solution.Results14 studies found an increase in PA. Walking was the most common form of PA. The most frequently utilised digital tool was an accelerometer. Group PA was more frequent than individual PA. Many studies used supervision within the intervention. Outcomes varied across studies.Conclusion: Digital PA interventions vary in design and show promise in increasing PA amongst the cohort. However, further research is needed to determine the feasibility and acceptability of digital tools and to incorporate different elements into the design of digital PA interventions, particularly for a long-term solution.
C1 [Forde, Shannon Aisling; Coppinger, Tara] Munster Technol Univ, Dept Sport Leisure & Childhood Studies, Cork T12 P928, Ireland.
   [Rea, Susan] Munster Technol Univ, Nimbus Res Ctr, Cork, Ireland.
   [Hanrahan, Sinead] Munster Technol Univ, Cork, Ireland.
C3 Munster Technological University (MTU); Munster Technological University
   (MTU)
RP Forde, SA (corresponding author), Munster Technol Univ, Dept Sport Leisure & Childhood Studies, Cork T12 P928, Ireland.
EM shannon.forde@mycit.ie
FU Taighde Eireann - Research ireland [18/cRt/6222]
FX this publication has emanated from research conducted with the financial
   support of taighde Eireann - Research ireland under Grant number
   18/cRt/6222.
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NR 74
TC 0
Z9 0
U1 0
U2 0
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1748-3107
EI 1748-3115
J9 DISABIL REHABIL-ASSI
JI Disabil. Rehabil.-Assist. Technol.
PD 2025 MAY 31
PY 2025
DI 10.1080/17483107.2025.2508938
EA MAY 2025
PG 22
WC Rehabilitation
WE Social Science Citation Index (SSCI)
SC Rehabilitation
GA 3GY9W
UT WOS:001500108000001
PM 40450697
DA 2025-06-11
ER

PT J
AU Macki, M
   Alvi, MA
   Kerezoudis, P
   Xiao, S
   Schultz, L
   Bazydlo, M
   Bydon, M
   Park, P
   Chang, V
AF Macki, Mohamed
   Alvi, Mohammed Ali
   Kerezoudis, Panagiotis
   Xiao, Shujie
   Schultz, Lonni
   Bazydlo, Michael
   Bydon, Mohamad
   Park, Paul
   Chang, Victor
CA MSSIC Investigators
TI Predictors of patient dissatisfaction at 1 and 2 years after lumbar
   surgery
SO JOURNAL OF NEUROSURGERY-SPINE
LA English
DT Article
DE lumbar; Michigan Spine Surgery Improvement Collaborative; MSSIC; NASS
   Patient Satisfaction Index; North American Spine Surgery
ID HEALTH-CARE PROVIDERS; RESEARCH TRIAL SPORT; NONOPERATIVE TREATMENT;
   SPINE SURGERY; CONSUMER ASSESSMENT; METABOLIC SYNDROME; DISK HERNIATION;
   FUSION SURGERY; FOLLOW-UP; OUTCOMES
AB OBJECTIVE As compensation transitions from a fee-for-service to pay-for-performance healthcare model, providers must prioritize patient-centered experiences. Here, the authors' primary aim was to identify predictors of patient dissatisfaction at 1 and 2 years after lumbar surgery.
   METHODS The Michigan Spine Surgery Improvement Collaborative (MSSIC) was queried for all lumbar operations at the 1- and 2-year follow-ups. Predictors of patients' postoperative contentment were identified per the North American Spine Surgery (NASS) Patient Satisfaction Index, wherein satisfied patients were assigned a score of 1 ("the treatment met my expectations") or 2 ("I did not improve as much as I had hoped, but I would undergo the same treatment for the same outcome") and unsatisfied patients were assigned a score of 3 ("I did not improve as much as I had hoped, and I would not undergo the same treatment for the same outcome") or 4 ("I am the same or worse than before treatment"). Multivariable Poisson generalized estimating equation models were used to report adjusted risk ratios (RRadj).
   RESULTS Among 5390 patients with a 1-year follow-up, 22% reported dissatisfaction postoperatively. Dissatisfaction was predicted by higher body mass index (RRadj =1.07, p < 0.001), African American race compared to white (RRadj = 1.51, p < 0.001), education level less than high school graduation compared to a high school diploma or equivalent (RRadj =1.25, p = 0.008), smoking (RRadj = 1.34, p < 0.001), daily preoperative opioid use > 6 months (RRadj = 1.22, p < 0.001), depression (RRadj = 1.31, p < 0.001), symptom duration > 1 year (RRadj = 1.32, p < 0.001), previous spine surgery (RRadj = 1.32, p < 0.001), and higher baseline numeric rating scale (NRS)-back pain score (RRadj = 1.04, p = 0.002). Conversely, an education level higher than high school graduation, independent ambulation (RRadj = 0.90, p = 0.039), higher baseline NRS-leg pain score (RRadj = 0.97, p = 0.013), and fusion surgery (RRadj = 0.88, p = 0.014) decreased dissatisfaction. Among 2776 patients with a 2-year follow-up, 22% reported dissatisfaction postoperatively. Dissatisfaction was predicted by a non-white race, current smoking (RRadj = 1.26, p = 0.004), depression (RRadj = 1.34, p < 0.001), symptom duration > 1 year (RRadj = 1.47, p < 0.001), previous spine surgery (RRadj = 1.28, p < 0.001), and higher baseline NRS-back pain score (RRadj = 1.06, p = 0.003). Conversely, at least some college education (RR adi = 0.87, p = 0.035) decreased the risk of dissatisfaction.
   CONCLUSIONS Both comorbid conditions and socioeconomic circumstances must be considered in counseling patients on postoperative expectations. After race, symptom duration was the strongest predictor of dissatisfaction; thus, patient-centered measures must be prioritized. These findings should serve as a tool for surgeons to identify at-risk populations that may need more attention regarding effective communication and additional preoperative counseling to address potential barriers unique to their situation.
C1 [Macki, Mohamed; Chang, Victor] Henry Ford Hosp, Dept Neurosurg, Detroit, MI 48202 USA.
   [Xiao, Shujie] Henry Ford Hosp, Dept Internal Med, Detroit, MI 48202 USA.
   [Schultz, Lonni; Bazydlo, Michael] Henry Ford Hosp, Dept Publ Hlth Sci, Detroit, MI 48202 USA.
   [Alvi, Mohammed Ali; Kerezoudis, Panagiotis; Bydon, Mohamad] Mayo Clin, Dept Neurosurg, Rochester, MN USA.
   [Park, Paul] Univ Michigan, Dept Neurosurg, Ann Arbor, MI 48109 USA.
C3 Henry Ford Health System; Henry Ford Hospital; Henry Ford Health System;
   Henry Ford Hospital; Henry Ford Health System; Henry Ford Hospital; Mayo
   Clinic; University of Michigan System; University of Michigan
RP Chang, V (corresponding author), Henry Ford Hosp, Detroit, MI 48202 USA.
EM vchang1@hfhs.org
RI Park, Paul/AGX-0276-2022; Alvi, Mohammed Ali/AFP-8378-2022
OI Park, Paul/0000-0002-0375-396X; Alvi, Mohammed Ali/0000-0002-7131-079X
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NR 45
TC 35
Z9 35
U1 0
U2 2
PU AMER ASSOC NEUROLOGICAL SURGEONS
PI ROLLING MEADOWS
PA 5550 MEADOWBROOK DRIVE, ROLLING MEADOWS, IL 60008 USA
SN 1547-5654
EI 1547-5646
J9 J NEUROSURG-SPINE
JI J. Neurosurg.-Spine
PD MAR
PY 2020
VL 32
IS 3
BP 373
EP 382
DI 10.3171/2019.8.SPINE19260
PG 10
WC Clinical Neurology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Surgery
GA KS6AS
UT WOS:000518390200006
PM 31756702
OA Bronze
DA 2025-06-11
ER

PT J
AU Lu, LH
   Tsai, CC
   Lin, CY
   Wang, CW
   Wu, PY
   Huang, JC
   Chen, SC
   Chang, JM
AF Lu, Lu-Heng
   Tsai, Chun-Chi
   Lin, Chih-Yi
   Wang, Chih-Wen
   Wu, Pei-Yu
   Huang, Jiun-Chi
   Chen, Szu-Chia
   Chang, Jer-Ming
TI Association and Interaction between Heavy Metals and Hyperuricemia in a
   Taiwanese Population
SO DIAGNOSTICS
LA English
DT Article
DE heavy metal; arsenic; hyperuricemia; risk factors
ID URIC-ACID; METABOLIC SYNDROME; OXIDATIVE STRESS; GOUT; CHROMIUM; LEAD;
   PREVALENCE; EXPOSURE; HEALTH; ANTIOXIDANT
AB The prevalence of hyperuricemia in Taiwan is high, and hyperuricemia has been associated with a risk of developing several diseases. Although the traditional risk factors for hyperuricemia are well known, the relationship between heavy metals and hyperuricemia is still undefined. Therefore, the aim of this study was to investigate the relationship between hyperuricemia and heavy metals. A total of 2447 participants (977 males and 1470 females) residing in southern Taiwan were enrolled, and levels of the following heavy metals were measured: lead in blood, and nickel, chromium, manganese, arsenic (As), copper, and cadmium in urine. Hyperuricemia was defined as a serum uric acid level greater than 7.0 mg/dL (416.5 mu mol/L) in men and 6.0 mg/dL (357 mu mol/L) in women. The participants were divided into two groups: those without hyperuricemia (n = 1821; 74.4%) and those with hyperuricemia (n = 626; 25.6%). Multivariate analysis showed that only high urine As (log per 1 mu g/g creatinine; odds ratio, 1.965; 95% confidence interval, 1.449 to 2.664; p < 0.001), young age, male sex, high body mass index, high hemoglobin, high triglycerides, and low estimated glomerular filtration rate were significantly associated with hyperuricemia. In addition, the interactions between Pb x Cd (p = 0.010), Ni x Cu (p = 0.002), and Cr x Cd (p = 0.001) on hyperuricemia were statistically significant. Increasing levels of Pb and Cr yielded an increased prevalence of hyperuricemia, and the effect was progressively greater for increasing Cd. Moreover, increasing levels of Ni yielded an increased prevalence of hyperuricemia, and the effect was progressively greater for increasing Cu. In conclusion, our results show that high urine As is associated with hyperuricemia, and some interactions of heavy metals on hyperuricemia are noted. We also found that young age, male sex, high BMI, high hemoglobin, high triglycerides, and low eGFR were significantly associated with hyperuricemia.
C1 [Lu, Lu-Heng] Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Gen Med, Kaohsiung 807, Taiwan.
   [Tsai, Chun-Chi] Kaohsiung Med Univ, Kaohsiung Municipal Siaogang Hosp, Dept Occupat Safety & Hlth, Kaohsiung 812, Taiwan.
   [Lin, Chih-Yi; Wang, Chih-Wen] Kaohsiung Med Univ, Kaohsiung Municipal Siaogang Hosp, Dept Environm & Occupat Med Ctr, Kaohsiung 812, Taiwan.
   [Wang, Chih-Wen; Wu, Pei-Yu; Huang, Jiun-Chi; Chen, Szu-Chia] Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Kaohsiung Municipal Siaogang Hosp, Dept Internal Med, Kaohsiung 812, Taiwan.
   [Wang, Chih-Wen; Chang, Jer-Ming] Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Internal Med, Div Hepatobiliary, Kaohsiung 807, Taiwan.
   [Wang, Chih-Wen; Wu, Pei-Yu; Huang, Jiun-Chi; Chen, Szu-Chia] Kaohsiung Med Univ, Coll Med, Fac Med, Kaohsiung 807, Taiwan.
   [Wu, Pei-Yu; Huang, Jiun-Chi; Chen, Szu-Chia; Chang, Jer-Ming] Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Internal Med, Div Nephrol, Kaohsiung 807, Taiwan.
   [Chen, Szu-Chia] Kaohsiung Med Univ, Res Ctr Precis Environm Med, Kaohsiung 807, Taiwan.
C3 Kaohsiung Medical University; Kaohsiung Medical University Hospital;
   Kaohsiung Medical University; Kaohsiung Municipal Siao-Gang Hospital;
   Kaohsiung Medical University; Kaohsiung Municipal Siao-Gang Hospital;
   Kaohsiung Medical University; Kaohsiung Municipal Siao-Gang Hospital;
   Kaohsiung Medical University Hospital; Kaohsiung Medical University;
   Kaohsiung Medical University Hospital; Kaohsiung Medical University;
   Kaohsiung Medical University; Kaohsiung Medical University Hospital;
   Kaohsiung Medical University
RP Chen, SC (corresponding author), Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Kaohsiung Municipal Siaogang Hosp, Dept Internal Med, Kaohsiung 812, Taiwan.; Chen, SC (corresponding author), Kaohsiung Med Univ, Coll Med, Fac Med, Kaohsiung 807, Taiwan.; Chen, SC (corresponding author), Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Internal Med, Div Nephrol, Kaohsiung 807, Taiwan.; Chen, SC (corresponding author), Kaohsiung Med Univ, Res Ctr Precis Environm Med, Kaohsiung 807, Taiwan.
EM luke01099314199@gmail.com; 1036124@kmuh.org.tw;
   joannalinnn0824@gmail.com; chinwin.wang@gmail.com; wpuw17@gmail.com;
   karajan77@gmail.com; scarchenone@yahoo.com.tw
RI Huang, Jiun-Chi/IAQ-1908-2023; wang, chihwen/C-6557-2013; 蘇,
   河名/AAE-9843-2019
OI Huang, Jiun-Chi/0000-0002-5897-2860; Chen, Szu-Chia/0000-0002-1610-4184;
   Chang, Jer-Ming/0000-0003-0071-1710
FU Research Center for Precision Environmental Medicine, Kaohsiung Medical
   University, Kaohsiung, Taiwan from The Featured Areas Research Center
   Program within Ministry of Education (MOE) in Taiwan; Kaohsiung Medical
   University Research Center Grant [KMU-TC111A01, KMUTC111IFSP01]
FX This work was supported partially by the Research Center for Precision
   Environmental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
   from The Featured Areas Research Center Program within the framework of
   the Higher Education Sprout Project by the Ministry of Education (MOE)
   in Taiwan and by Kaohsiung Medical University Research Center Grant
   (KMU-TC111A01 and KMUTC111IFSP01).
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NR 65
TC 5
Z9 5
U1 1
U2 18
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2075-4418
J9 DIAGNOSTICS
JI Diagnostics
PD MAY 15
PY 2023
VL 13
IS 10
AR 1741
DI 10.3390/diagnostics13101741
PG 15
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA H6MZ2
UT WOS:000997094600001
PM 37238228
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Oraphruek, P
   Chusak, C
   Ngamukote, S
   Sawaswong, V
   Chanchaem, P
   Payungporn, S
   Suantawee, T
   Adisakwattana, S
AF Oraphruek, Piyarat
   Chusak, Charoonsri
   Ngamukote, Sathaporn
   Sawaswong, Vorthon
   Chanchaem, Prangwalai
   Payungporn, Sunchai
   Suantawee, Tanyawan
   Adisakwattana, Sirichai
TI Effect of a Multispecies Synbiotic Supplementation on Body Composition,
   Antioxidant Status, and Gut Microbiomes in Overweight and Obese
   Subjects: A Randomized, Double-Blind, Placebo-Controlled Study
SO NUTRIENTS
LA English
DT Article
DE probiotic; prebiotic; synbiotic; overweight and obesity; gut microbiota
ID OXIDATIVE STRESS; METABOLIC SYNDROME; WEIGHT MANAGEMENT; ADULTS;
   INFLAMMATION; CONSUMPTION; PROBIOTICS; CAPACITY; MARKERS; ALTERS
AB Studies investigating the effect of multispecies synbiotic supplementation in obesity management are limited. The current study was performed to evaluate the effects of multispecies probiotics mixed with fructooligosaccharides on body composition, antioxidant status, and gut microbiome composition in overweight and obese individuals. We employed a randomized, double-blind, placebo-controlled trial design, in which 63 individuals aged 18-45 years were assigned to receive either a synbiotic supplement or placebo for 12 weeks. The synbiotic group consumed a daily dose of 37 x 10(9) colony-forming units (CFU) of a unique blend of seven different probiotics, along with 2 g of fructooligosaccharides, while the placebo group consumed 2 g of maltodextrin daily. Assessments were performed at baseline, week 6, and the end of the study. The results of the study indicated that synbiotic supplementation resulted in a significant reduction in waist circumference and body fat percentage compared to the baseline measurements, as observed at 12 weeks. At the end of the study, there were no significant differences observed in body weight, BMI, waist circumference, or percentage of body fat between the synbiotic group and the placebo group. An analysis of plasma antioxidant capacity revealed that synbiotic supplementation caused a significant increase in Trolox equivalent antioxidant capacity (TEAC) and a concomitant decrease in malondialdehyde (MDA) in the test group when compared to the placebo. For the gut microbiota analysis, synbiotic supplementation significantly decreased Firmicutes abundance and the Firmicutes/Bacteroidetes (F/B) ratio at week 12 as compared to the placebo group. Nevertheless, the synbiotic group did not exhibit any substantial alterations in other biochemical blood parameters compared to the placebo group. These findings suggest that multispecies synbiotic supplementation could be a beneficial strategy to improve body composition, antioxidant status, and gut microbiome composition in overweight and obese subjects.
C1 [Oraphruek, Piyarat; Chusak, Charoonsri; Ngamukote, Sathaporn; Suantawee, Tanyawan; Adisakwattana, Sirichai] Chulalongkorn Univ, Fac Allied Hlth Sci, Dept Nutr & Dietet, Phytochem & Funct Food Res Unit Clin Nutr, Bangkok 10330, Thailand.
   [Sawaswong, Vorthon; Chanchaem, Prangwalai; Payungporn, Sunchai] Chulalongkorn Univ, Fac Med, Ctr Excellence Syst Microbiol, Bangkok 10330, Thailand.
   [Payungporn, Sunchai] Chulalongkorn Univ, Fac Med, Dept Biochem, Bangkok 10330, Thailand.
C3 Chulalongkorn University; Chulalongkorn University; Chulalongkorn
   University
RP Suantawee, T (corresponding author), Chulalongkorn Univ, Fac Allied Hlth Sci, Dept Nutr & Dietet, Phytochem & Funct Food Res Unit Clin Nutr, Bangkok 10330, Thailand.
EM tanyawan.s@chula.ac.th
OI Suantawee, Tanyawan/0000-0001-5691-0511; Adisakwattana,
   Sirichai/0000-0002-7938-6561; Payungporn, Sunchai/0000-0003-2668-110X
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NR 65
TC 17
Z9 18
U1 2
U2 10
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD APR
PY 2023
VL 15
IS 8
AR 1863
DI 10.3390/nu15081863
PG 16
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA E6ZP8
UT WOS:000977005100001
PM 37111082
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Nomura, S
   Murakami, M
   Ozaki, A
   Sawano, T
   Leppold, C
   Nishikawa, Y
   Saito, H
   Oikawa, T
   Tsubokura, M
AF Nomura, Shuhei
   Murakami, Michio
   Ozaki, Akihiko
   Sawano, Toyoaki
   Leppold, Claire
   Nishikawa, Yoshitaka
   Saito, Hiroaki
   Oikawa, Tomoyoshi
   Tsubokura, Masaharu
TI Comparative risk assessment of non-communicable diseases by evacuation
   scenario- a retrospective study in the 7 years following the Fukushima
   Daiichi nuclear power plant accident
SO GLOBAL HEALTH ACTION
LA English
DT Article
DE Japan; Fukushima; evacuation; non-communicable diseases
ID POSTTRAUMATIC-STRESS-DISORDER; EAST JAPAN EARTHQUAKE; INVERSE
   PROBABILITY; METABOLIC SYNDROME; HURRICANE-KATRINA; CLINICAL-PRACTICE;
   HEART-FAILURE; HEALTH-CARE; DISASTER; HYPERTENSION
AB Background: As a result of the Fukushima Daiichi nuclear power plant accident, many residents evacuated and were exposed to changes in their living environment and socioeconomic status, and to persistent stressors. Past studies have suggested the potential for these circumstances to contribute to long-term changes to population health.
   Objective: The objective of this study was to gain a better understanding of long-term health effects of evacuation, by evaluating the risk of non-communicable diseases among evacuees from Minamisoma City (one of the closest municipalities to the power plant) until 2017.
   Methods: The study evaluated data from annual health check-ups for residents aged 40-74 years covered by National Health Insurance (who are largely self-employed) from 2010 to 2017 administered by Minamisoma City. Diabetes, hyperlipidemia, and hypertension were defined from the results of blood sampling. Annual changes in age-adjusted prevalence were estimated by evacuation scenario. We also performed an inverse-probability weighting (IPW) analysis to adjust for baseline covariates in 2010 and estimated the differences in the risk of diabetes, hyperlipidemia, and hypertension by evacuation scenario as of the 2017 health check-up in reference to the no-evacuation group.
   Results: A total of 1,837 individuals were considered in this study. Regardless of evacuation scenario, there was statistical evidence suggesting an upward and a downward trend in diabetes and hypertension from 2010 to 2017, respectively, while hyperlipidemia showed no remarkable change. IPW analyses demonstrated that disease risks in 2017 did not differ significantly among people with different evacuation scenarios.
   Conclusions: Region-specific factors played an important role in the health effects of the evacuation. Our findings have important implications for the need of an assessment of the health effects of evacuations in more localized manner. Further research in this area will strengthen the communities' preparedness for future disasters that require mass evacuation.
C1 [Nomura, Shuhei; Ozaki, Akihiko; Sawano, Toyoaki; Tsubokura, Masaharu] Minamisoma Municipal Gen Hosp, Res Ctr Community Hlth, Fukushima, Japan.
   [Nomura, Shuhei] Univ Tokyo, Grad Sch Med, Dept Global Hlth Policy, Tokyo, Japan.
   [Nomura, Shuhei] Keio Univ, Sch Med, Dept Hlth Policy & Management, Tokyo, Japan.
   [Murakami, Michio] Fukushima Med Univ, Sch Med, Dept Hlth Risk Commun, Fukushima, Japan.
   [Ozaki, Akihiko] Tokiwa Fdn, Jyoban Hosp, Dept Breast Surg, Fukushima, Japan.
   [Sawano, Toyoaki] Tokiwa Fdn, Jyoban Hosp, Dept Surg, Fukushima, Japan.
   [Sawano, Toyoaki; Saito, Hiroaki; Tsubokura, Masaharu] Fukushima Med Univ, Sch Med, Dept Radiat Hlth Management, Fukushima, Japan.
   [Leppold, Claire] Univ Melbourne, Ctr Hlth Equ, Melbourne Sch Populat & Global Hlth, Child & Community Wellbeing Unit, Melbourne, Vic, Australia.
   [Nishikawa, Yoshitaka] Soma Cent Hosp, Dept Internal Med, Fukushima, Japan.
   [Nishikawa, Yoshitaka] Kyoto Univ, Sch Publ Hlth, Dept Hlth Informat, Kyoto, Japan.
   [Saito, Hiroaki] Sendai Kousei Hosp, Dept Gastroenterol, Sendai, Miyagi, Japan.
   [Oikawa, Tomoyoshi] Minamisoma Municipal Gen Hosp, Dept Neurosurg, Fukushima, Japan.
C3 University of Tokyo; Keio University; Fukushima Medical University;
   Fukushima Medical University; University of Melbourne; Kyoto University;
   Sendai Kousei Hospital
RP Nomura, S (corresponding author), Keio Univ, Sch Med, Dept Hlth Policy & Management, Shinjuku Ku, 35 Shinanomachi, Tokyo 1608582, Japan.
EM s-nomura@keio.jp
RI SAITO, HIROAKI/HLH-2447-2023; Tsubokura, Masaharu/AAV-4364-2021; Nomura,
   Shuhei/HCH-5356-2022; Murakami, Michio/JTS-8578-2023; Ozaki,
   Akihiko/AAD-3889-2021; Nishikawa, Yoshitaka/GLV-3579-2022; Tsubokura,
   Masaharu/D-7300-2017
OI Nishikawa, Yoshitaka/0000-0003-3313-1990; Ozaki,
   Akihiko/0000-0003-4415-9657; Nomura, Shuhei/0000-0002-2963-7297;
   Leppold, Claire/0000-0003-4268-3105; Tsubokura,
   Masaharu/0000-0001-8027-202X
FU Japan Society for the Promotion of Science [KAKEN JP20H04354]; Research
   project on the Health Effects of Radiation by Ministry of the
   Environment, Japan; Ministry of the Environment; Grants-in-Aid for
   Scientific Research [20H04354] Funding Source: KAKEN
FX The present work was supported in part by a grant from the Japan Society
   for the Promotion of Science (KAKEN JP20H04354), and by Research project
   on the Health Effects of Radiation organized by Ministry of the
   Environment, Japan; Ministry of the Environment.
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NR 76
TC 6
Z9 6
U1 0
U2 5
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
EI 1654-9880
J9 GLOBAL HEALTH ACTION
JI Glob. Health Action
PD JAN 1
PY 2021
VL 14
IS 1
AR 1918886
DI 10.1080/16549716.2021.1918886
PG 13
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA SL1OB
UT WOS:000656687700001
PM 34058969
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Alaagib, N
   Sukkar, M
   Kardash, M
AF Alaagib, Nouralsalhin
   Sukkar, Mohammed
   Kardash, Mohammed
TI The Effects of Salt and Glucose Intake on Angiotensin II and Aldosterone
   in Obese and Nonobese Patients with Essential Hypertension
SO INTERNATIONAL JOURNAL OF HYPERTENSION
LA English
DT Article
ID NATRIURETIC PEPTIDES; BODY-MASS; METABOLIC SYNDROME; OXIDATIVE STRESS;
   SODIUM-CHANNELS; BLOOD-PRESSURE; RECEPTOR; SYSTEM; IMPACT; PATHOGENESIS
AB Background. The exact mechanisms for the development of essential hypertension are not known. Activation of the renin-angiotensin-aldosterone system (RAAS) in adipose tissue may represent an important link between obesity and hypertension. This study investigates the effects of oral intake of glucose with and without NaCl on angiotensin II (AngII) and aldosterone in obese and nonobese patients with essential hypertension. Methods. Twenty newly diagnosed untreated essential hypertensive patients and 15 normotensive control subjects matched for age, gender, and BMI were studied. Participants fasted overnight (8-10 hrs), and then each subject took 75 gm glucose alone and with 3 gm NaCl, each dissolved in 250 ml. Subjects were monitored for 2 hours. Half hourly BP, plasma glucose (PG), serum Na+, K+, insulin, AngII, and aldosterone were measured. Subjects were classified into obese (BMI >30 Kg/m(2)) (11 patients and 8 control) and nonobese (BMI <30 Kg/m(2)) (9 patients and 7 control). Results. After intake of glucose with NaCl serum, AngII was significantly higher in obese hypertensive patients compared with nonobese patients (P=0.016). Intake of glucose with NaCl resulted in a significantly higher serum Na in obese hypertensive patients compared with nonobese patients Na (P=0.009). Serum aldosterone was significantly higher in obese patients (P=0.03, after glucose; P=0.003, after glucose with NaCl) and in nonobese patients (P=0.000 and P=0.000, respectively) compared with their respective normotensive control subjects. In obese and nonobese patients, intake of glucose and glucose with NaCl showed no significant change in the levels of serum AngII and aldosterone which was associated a significant increase in serum Na in obese patients (P=0.03) and a highly significant reduction in serum K in nonobese patients (P=0.001). Conclusion. Failure of suppression or inappropriate maintenance of secretion of AngII and aldosterone in both hypertensive groups by intake of glucose with NaCl may indicate a possible mechanism of essential hypertension.
C1 [Alaagib, Nouralsalhin] Univ Khartoum, Dept Physiol, Fac Med, Khartoum, Sudan.
   [Sukkar, Mohammed] Nile Univ, Fac Med, Khartoum, Sudan.
   [Kardash, Mohammed] Omdurman Ahlia Univ, Fac Med, Omdurman, Sudan.
C3 University of Khartoum
RP Alaagib, N (corresponding author), Univ Khartoum, Dept Physiol, Fac Med, Khartoum, Sudan.
EM nouralsalhin@gmail.com; profmys@gmail.com; dr.m.m.kardash@gmail.com
RI Alaagib, Nouralsalhin/AAW-1000-2021
OI Alaagib, Nouralsalhin/0000-0001-7466-1248
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NR 56
TC 5
Z9 5
U1 0
U2 1
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2090-0384
EI 2090-0392
J9 INT J HYPERTENS
JI Int. J. Hypertens.
PD MAR 19
PY 2020
VL 2020
AR 6017105
DI 10.1155/2020/6017105
PG 9
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA KZ6SG
UT WOS:000523389000002
PM 32257423
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Baratta, F
   Pastori, D
   Polimeni, L
   Bucci, T
   Ceci, F
   Calabrese, C
   Ernesti, I
   Pannitteri, G
   Violi, F
   Angelico, F
   Del Ben, M
AF Baratta, Francesco
   Pastori, Daniele
   Polimeni, Licia
   Bucci, Tommaso
   Ceci, Fabrizio
   Calabrese, Cinzia
   Ernesti, Ilaria
   Pannitteri, Gaetano
   Violi, Francesco
   Angelico, Francesco
   Del Ben, Maria
TI Adherence to Mediterranean Diet and Non-Alcoholic Fatty Liver Disease:
   Effect on Insulin Resistance
SO AMERICAN JOURNAL OF GASTROENTEROLOGY
LA English
DT Article
ID METABOLIC SYNDROME; OXIDATIVE STRESS; POPULATION; PREVALENCE; RISK;
   QUESTIONNAIRE; INFLAMMATION; ASSOCIATION; GUIDELINES; MANAGEMENT
AB OBJECTIVES: The prevalence of cardiometabolic disorders, including non-alcoholic fatty liver disease (NAFLD), is increasing in western countries, because of changes in lifestyle and dietary habits. Mediterranean Diet (Med-Diet) is effective for cardiovascular prevention, but its relationship with NAFLD has been scarcely investigated.
   METHODS: We included 584 consecutive outpatients presenting with one or more cardiovascular risk factor such as type 2 diabetes mellitus (T2DM), arterial hypertension, overweight/obesity, and dyslipidemia. Liver steatosis was assessed using ultrasonography. Med-Diet adherence was investigated by a validated semiquantitative nine-item dietary questionnaire; patients were divided into low, intermediate, and high adherence. Insulin resistance was defined by the 75th percentile of homeostasis model of insulin resistance (HOMA-IR; >= 3.8).
   RESULTS: The mean age was 56.2 +/- 12.4 years and 38.2% were women. Liver steatosis was present in 82.7%, and its prevalence decreased from low to high adherence group (96.5% vs. 71.4%, P<0.001). In a multiple logistic regression analysis, hypertriglyceridemia (odds ratio (OR): 2.913; P=0.002), log (ALT) (OR: 6.186; P<0.001), Med-Diet adherence (intermediate vs. low OR: 0.115; P=0.041, high vs. low OR: 0.093; P=0.030), T2DM (OR: 3.940; P=0.003), and high waist circumference (OR: 3.012; P<0.001) were associated with NAFLD. Among single foods, low meat intake (OR: 0.178; P<0.001) was inversely significantly associated with NAFLD. In 334 non-diabetic NAFLD patients, age (OR: 1.035, P=0.025), high waist circumference (OR: 7.855, P<0.001), hypertriglyceridemia (OR: 2.152, P=0.011), and Log (ALT) (OR: 2.549, P=0.002) were directly associated with HOMA-IR, whereas Med-Diet score was inversely associated (OR: 0.801, P=0.018).
   CONCLUSIONS: We found an inverse relationship between Med-Diet and NAFLD prevalence. Among NAFLD patients, good adherence to Med-Diet was associated with lower insulin resistance. Our findings suggest that Med-Diet may be a beneficial nutritional approach in NAFLD patients.
C1 [Baratta, Francesco; Pastori, Daniele; Polimeni, Licia; Violi, Francesco] Sapienza Univ Rome, Dept Internal Med & Med Specialties, Clin Med 1, Viale Policlin 155, I-00161 Rome, Italy.
   [Baratta, Francesco; Pastori, Daniele] Sapienza Univ Rome, Dept Anat Histol Forens Med & Orthoped Sci, Rome, Italy.
   [Bucci, Tommaso] Salerno Univ Med, Dept Med Specialties, Salerno, Italy.
   [Ceci, Fabrizio] Univ Roma La Sapienza, Dept Cellular Biotechnol & Hematol, Policlin Umberto Hosp 1, Rome, Italy.
   [Ernesti, Ilaria] Sapienza Univ, Sect Med Pathophysiol Endocrinol & Nutr, Dept Expt Med, Rome, Italy.
   [Pannitteri, Gaetano] Sapienza Univ Rome, Dept Cardiovasc Resp Nephrol Anaesthesiol & Geria, Rome, Italy.
   [Angelico, Francesco] Sapienza Univ Rome, Dept Publ Hlth & Infect Dis, Rome, Italy.
C3 Sapienza University Rome; Sapienza University Rome; Sapienza University
   Rome; University Hospital Sapienza Rome; Sapienza University Rome;
   Sapienza University Rome; Sapienza University Rome
RP Pastori, D (corresponding author), Sapienza Univ Rome, Dept Internal Med & Med Specialties, Clin Med 1, Viale Policlin 155, I-00161 Rome, Italy.
EM daniele.pastori@uniroma1.it
RI Angelico, Francesco/AAB-6585-2020; Violi, Francesco/K-1509-2016; Del
   Ben, Maria/AAE-7603-2020; Bucci, Tommaso/ABA-4162-2021; pastori,
   daniele/J-7087-2016
OI Bucci, Tommaso/0000-0003-2895-6234; Baratta,
   Francesco/0000-0003-1708-272X; pastori, daniele/0000-0001-6357-5213;
   Calabrese, Cinzia Myriam/0000-0001-5376-0298
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NR 51
TC 117
Z9 122
U1 0
U2 23
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0002-9270
EI 1572-0241
J9 AM J GASTROENTEROL
JI Am. J. Gastroenterol.
PD DEC
PY 2017
VL 112
IS 12
BP 1832
EP 1839
DI 10.1038/ajg.2017.371
PG 8
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA FP3HR
UT WOS:000417509800016
PM 29063908
DA 2025-06-11
ER

PT J
AU Aregbesola, A
   Virtanen, JK
   Voutilainen, S
   Mursu, J
   Lagundoye, A
   Kauhanen, J
   Tuomainen, TP
AF Aregbesola, Alex
   Virtanen, Jyrki K.
   Voutilainen, Sari
   Mursu, Jaakko
   Lagundoye, Ayodele
   Kauhanen, Jussi
   Tuomainen, Tomi-Pekka
TI Serum ferritin and glucose homeostasis: change in the association by
   glycaemic state
SO DIABETES-METABOLISM RESEARCH AND REVIEWS
LA English
DT Article
DE body iron; serum ferritin; HOMA; glycaemia; insulin resistance; beta
   cell function
ID BODY IRON STORES; ACUTE MYOCARDIAL-INFARCTION; INSULIN-RESISTANCE;
   BETA-CELL; TRANSFERRIN RECEPTOR; METABOLIC SYNDROME; OXIDATIVE STRESS;
   RISK; ADIPONECTIN; LIVER
AB BackgroundData on the association between body iron and glucose homeostasis by the three glycaemic states are scarce. Thus, we investigated the association between body iron as assessed by a serum ferritin concentration and glucose homeostasis using homeostasis model assessment (HOMA) of insulin resistance (HOMA-IR) and beta cell function (HOMA-BcF) in different glycaemic states.
   MethodsA cross-sectional analysis was conducted in 2541 men aged 42-60years in 1984-1989 in the Kuopio Ischemic Heart Disease Risk Factor Study. Subjects were classified into the three glycaemic states, normoglycaemia, prediabetes and type 2 diabetes (T2D), by fasting plasma glucose measurements and the information collected at study visit. The association between serum ferritin quartiles and HOMA-IR and HOMA-BcF for each glycaemic state was examined by analysis of covariance and linear regression analysis.
   ResultsThe mean age and serum ferritin concentrations were 53.1years (standard deviation=5.7, range=42.0-61.3years) and 166.2 mu g/L (standard deviation=141.7, range=11-960 mu g/L), respectively. After multivariable adjustments, a weak and direct association was observed between serum ferritin quartiles and HOMA-IR in normoglycaemia (P-trend=0.001) but a direct association in prediabetes (P-trend=0.007) and in T2D (P-trend=0.078). In HOMA-BcF, the association was weak and direct in normoglycaemia (P-trend=0.003), direct in prediabetes (P-trend=0.005) and inverse in T2D (P-trend=0.105). Strongest associations were observed in prediabetes (=0.25, 95% confidence interval=0.14-0.36 and P=0.004 in HOMA-IR; =0.23, 95% confidence interval=0.15-0.31 and P=0.008 in HOMA-BcF) after a 100-mu g/L increase in serum ferritin (log-transformed).
   ConclusionsThese data suggest that both the strength and the direction of the association between body iron stores and glucose homeostasis are dependent on the glycaemic state of the population. Copyright (c) 2014 John Wiley & Sons, Ltd.
C1 [Aregbesola, Alex; Virtanen, Jyrki K.; Voutilainen, Sari; Mursu, Jaakko; Lagundoye, Ayodele; Kauhanen, Jussi; Tuomainen, Tomi-Pekka] Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland.
C3 University of Eastern Finland
RP Aregbesola, A (corresponding author), Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Yliopistonranta 1C,POB 1627, Kuopio, Finland.
EM alex.aregbesola@uef.fi
RI Murphy, Neil/E-1189-2017; Kauhanen, Jussi/ABC-4064-2021; Aregbesola,
   Alex/B-6643-2013; Virtanen, Jyrki/G-5149-2013
OI Virtanen, Jyrki/0000-0002-0648-999X
FU Finnish Cultural Foundation (North Savo Region) research grant
FX This work was supported by the Finnish Cultural Foundation (North Savo
   Region) research grant to Alex Aregbesola.
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NR 41
TC 13
Z9 13
U1 0
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1520-7552
EI 1520-7560
J9 DIABETES-METAB RES
JI Diabetes-Metab. Res. Rev.
PD JUL
PY 2015
VL 31
IS 5
BP 507
EP 514
DI 10.1002/dmrr.2628
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA CM2BS
UT WOS:000357485200008
PM 25470760
DA 2025-06-11
ER

PT J
AU Song, GH
   Lin, QQ
   Zhao, H
   Liu, MY
   Ye, FL
   Sun, YJ
   Yu, Y
   Guo, SD
   Jiao, P
   Wu, Y
   Ding, GY
   Xiao, Q
   Qin, SC
AF Song, Guohua
   Lin, Quanqiang
   Zhao, Hui
   Liu, Meiyuan
   Ye, Fenglong
   Sun, Yujuan
   Yu, Yang
   Guo, Shoudong
   Jiao, Peng
   Wu, Yun
   Ding, Guoyong
   Xiao, Qiang
   Qin, Shucun
TI Hydrogen Activates ATP-Binding Cassette Transporter A1-Dependent Efflux
   Ex Vivo and Improves High-Density Lipoprotein Function in Patients With
   Hypercholesterolemia: A Double-Blinded, Randomized, and
   Placebo-Controlled Trial
SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Article
ID ESTER TRANSFER PROTEIN; BETA-HDL FORMATION; CHOLESTEROL LEVELS;
   APOLIPOPROTEIN-M; HEART-DISEASE; RAISING HDL; DECREASES; INFLAMMATION;
   METABOLISM; PLASMA
AB Context: We have found that hydrogen (dihydrogen [H-2]) decreases plasma low-density lipoprotein (LDL) cholesterol levels and improves high-density lipoprotein (HDL) function in patients with potential metabolic syndrome in a before-after self-controlled study.
   Objective: The purpose of this study was to further characterize the effects of H-2-rich water (0.9 L/day) on the content, composition, and biological activities of plasma lipoproteins on patients with hypercholesterolemia and their underlying mechanisms in a double-blinded, randomized, and placebo-controlled trial.
   Design: This was a case-control study.
   Setting: The setting was the Zhoudian community, Tai'an, China.
   Patients: A total of 68 patients with untreated isolated hypercholesterolemia were randomly allocated to either drinking H-2-rich water (n = 34) or placebo water (n = 34) for 10 weeks.
   Results: HDL isolated from the H-2 group showed an increased ability to promote the ATP-binding cassette transporter A1-mediated cholesterol efflux ex vivo. Plasma pre-beta-HDL levels were up-regulated although there were no changes in plasma HDL-cholesterol levels. Moreover, other HDL functions, assessed in protection against LDL oxidation, inhibition of oxidized-LDL-induced inflammation, and protection of endothelial cells from oxidized-LDL-induced apoptosis, were all significantly improved by H-2 treatment. In addition, H-2 treatment increased the effective rate in down-regulating plasma levels of total cholesterol (47.06% vs 17.65%) and LDL cholesterol (47.06% vs 23.53%). Western blot analysis revealed a marked decrease in apolipoprotein B100 and an increase in apolipoprotein M in plasma of the H-2 group. Finally H-2 treatment resulted in a significant reduction in the levels of several inflammatory and oxidative stress indicators in whole plasma and HDL particles.
   Conclusions: H-2 activates ATP-binding cassette transporter A1-dependent efflux, enhances HDL antiatherosclerotic functions, and has beneficial lipid-lowering effects. The present findings highlight the potential role of H-2 in the regression of hypercholesterolemia and atherosclerosis.
C1 [Song, Guohua; Lin, Quanqiang; Zhao, Hui; Yu, Yang; Guo, Shoudong; Jiao, Peng; Qin, Shucun] TaiShan Med Univ, Key Lab Atherosclerosis Univ Shandong, Tai An 271000, Shandong, Peoples R China.
   [Song, Guohua; Lin, Quanqiang; Zhao, Hui; Yu, Yang; Guo, Shoudong; Jiao, Peng; Qin, Shucun] TaiShan Med Univ, Inst Atherosclerosis, Tai An 271000, Shandong, Peoples R China.
   [Song, Guohua; Lin, Quanqiang; Wu, Yun; Xiao, Qiang; Qin, Shucun] TaiShan Med Univ, Ctr Heart, Tai An 271000, Shandong, Peoples R China.
   [Liu, Meiyuan; Sun, Yujuan] Daiyue Dist, Zhoudian Community, Tai An 271021, Shandong, Peoples R China.
   [Ye, Fenglong] Taian He Ren Tang Hosp, Tai An 271021, Shandong, Peoples R China.
   [Wu, Yun; Xiao, Qiang; Qin, Shucun] Taishan Med Univ, Affiliated Hosp, Dept Cardiol, Tai An 271000, Shandong, Peoples R China.
   [Ding, Guoyong] TaiShan Med Univ, Inst Publ Hlth, Tai An 271000, Shandong, Peoples R China.
C3 Taishan University; Shandong First Medical University & Shandong Academy
   of Medical Sciences; Taishan University; Shandong First Medical
   University & Shandong Academy of Medical Sciences; Taishan University;
   Shandong First Medical University & Shandong Academy of Medical
   Sciences; Shandong First Medical University & Shandong Academy of
   Medical Sciences; Taishan University; Taishan University; Shandong First
   Medical University & Shandong Academy of Medical Sciences
RP Qin, SC (corresponding author), TaiShan Med Univ, Inst Atherosclerosis, 2 YingSheng East Rd, Taishan 271000, Shandong, Peoples R China.
EM tyfy8011@126.com; shucunqin@hotmail.com
FU Science and Technology Development Program of Shandong Province
   [2013GSF11830, 2014GSF118081]; Taishan Scholars Foundation of Shandong
   Province [200867]; National Natural Science Foundation of China
   [81170785, 81200216]; Promotive Research Fund for Excellent Young and
   Middle-Aged Scientists of Shandong Province [BS2012YY034]
FX This research was supported by the Science and Technology Development
   Program of Shandong Province (2013GSF11830 and 2014GSF118081), the
   Taishan Scholars Foundation of Shandong Province (200867), the National
   Natural Science Foundation of China (81170785 and 81200216), and the
   Promotive Research Fund for Excellent Young and Middle-Aged Scientists
   of Shandong Province (BS2012YY034).
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Z9 49
U1 0
U2 15
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0021-972X
EI 1945-7197
J9 J CLIN ENDOCR METAB
JI J. Clin. Endocrinol. Metab.
PD JUL
PY 2015
VL 100
IS 7
BP 2724
EP 2733
DI 10.1210/jc.2015-1321
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA CQ8EZ
UT WOS:000360840600045
PM 25978109
OA Bronze
DA 2025-06-11
ER

PT J
AU Khan, BV
   Merchant, N
   Rahman, ST
   Ahmad, M
   Parrott, JM
   Umar, K
   Johnson, J
   Ferdinand, KC
AF Khan, Bobby V.
   Merchant, Nadya
   Rahman, Syed T.
   Ahmad, Mushtaq
   Parrott, Janice M.
   Umar, Kanwal
   Johnson, Julie
   Ferdinand, Keith C.
TI Changes in Central Aortic Pressure, Endothelial Function and Biomarkers
   in Hypertensive African-Americans with the Cardiometabolic Syndrome:
   Comparison of Amlodipine/Olmesartan versus Hydrochlorothiazide/Losartan
SO CARDIORENAL MEDICINE
LA English
DT Article
DE Cardiometabolic syndrome; African-Americans; Compliance; Inflammation;
   Hypertension
ID CORONARY-HEART-DISEASE; UNITED-STATES ADULTS; METABOLIC SYNDROME;
   OLMESARTAN MEDOXOMIL; BLOOD-PRESSURE; DOUBLE-BLIND;
   CARDIOVASCULAR-DISEASE; OXIDATIVE STRESS; PARALLEL-GROUP; TASK-FORCE
AB Sixty-six self-identified African-American subjects with stage 1 and 2 hypertension and characteristics of the cardiometabolic syndrome were treated with amlodipine/olmesartan (A/O) versus losartan/hydrochlorothiazide (L/H) for 20 weeks in an open-label, active comparator fashion. Subjects not meeting a blood pressure (BP) value of <125/75 mm Hg on either regimen at week 14 were placed on additional or alternative therapy. After 20 weeks of therapy, systolic BP was reduced by 34.6 +/- 4.2 mm Hg in the A/O group and by 27.0 +/- 4.1 mm Hg in the L/H group (p = 0.012 A/O vs. L/H). Diastolic BP was reduced by 16.9 +/- 2.0 mm Hg in the A/O group and by 12.3 +/- 2.0 mm Hg in the L/H group (p = 0.022 A/O vs. L/H). There was a substantial increase in endothelial function of 44 and 103% in the L/H and A/O groups, respectively (p < 0.005 A/O vs. L/H). Central aorta augmentation pressure was significantly reduced by 42% with the A/O treatment, and a smaller, significant reduction of 28% was observed with the L/H treatment (p = 0.034 A/O vs. L/H). There was a reduction in sIL-6 levels of 20 and 33%, a reduction in serum leptin levels of 22 and 40%, and an increase in serum adiponectin of 19 and 46% in the L/H and A/O groups, respectively (p < 0.005 A/O vs. L/H for each biomarker). Treatment with A/O after 14 weeks reduced pulse wave velocity by 22% (p = 0.011 time comparison), whereas L/H treatment had no significant effect. Our findings suggest that, in addition to effective BP reduction, A/O differentially regulates markers of inflammation and obesity, thereby potentially providing greater vascular protection. (C) 2013 S. Karger AG, Basel
C1 [Khan, Bobby V.; Merchant, Nadya; Rahman, Syed T.; Parrott, Janice M.; Umar, Kanwal; Johnson, Julie; Ferdinand, Keith C.] Atlanta Vasc Res Fdn, Atlanta, GA 30342 USA.
   [Ahmad, Mushtaq] Morehouse Univ, Sch Med, Atlanta, GA USA.
C3 Morehouse College
RP Khan, BV (corresponding author), Atlanta Vasc Res Fdn, 5673 Peachtree Dunwoody Rd,Suite 440, Atlanta, GA 30342 USA.
EM bobby.khan@atlantaclinicalresearch.com
RI Muafa, Hussein Mussa Ahmed/IWE-4818-2023
OI Muafa, Hussein Mussa Ahmed/0000-0002-5290-025X
FU Daiichi Sankyo, Inc.
FX This study was supported by an unrestricted grant from Daiichi Sankyo,
   Inc. to Drs. Khan and Ferdinand, and the study drugs
   (amlodipine/olmesartan and losartan/HCTZ) were provided by Daiichi
   Sankyo, Inc. The other authors have no conflicts of interest to disclose
   regarding this study or the preparation of the manuscript.
CR Barrios V, 2009, CLIN DRUG INVEST, V29, P427, DOI 10.2165/00044011-200929070-00001
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NR 37
TC 4
Z9 4
U1 0
U2 2
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1664-3828
EI 1664-5502
J9 CARDIORENAL MED
JI CardioRenal Med.
PY 2013
VL 3
IS 4
BP 221
EP 231
DI 10.1159/000355136
PG 11
WC Cardiac & Cardiovascular Systems; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Urology & Nephrology
GA 278UL
UT WOS:000328915300001
PM 24474950
OA Green Published
DA 2025-06-11
ER

PT J
AU Pooya, S
   Blaise, S
   Garcia, MM
   Giudicelli, J
   Alberto, JM
   Guéant-Rodriguez, RM
   Jeannesson, E
   Gueguen, N
   Bressenot, A
   Nicolas, B
   Malthiery, Y
   Daval, JL
   Peyrin-Biroulet, L
   Bronowicki, JP
   Guéant, JL
AF Pooya, Shabnam
   Blaise, Sebastien
   Garcia, Maira Moreno
   Giudicelli, Jean
   Alberto, Jean-Marc
   Gueant-Rodriguez, Rosa-Maria
   Jeannesson, Elise
   Gueguen, Naig
   Bressenot, Aude
   Nicolas, Benedicte
   Malthiery, Yves
   Daval, Jean-Luc
   Peyrin-Biroulet, Laurent
   Bronowicki, Jean-Pierre
   Gueant, Jean-Louis
TI Methyl donor deficiency impairs fatty acid oxidation through PGC-1α
   hypomethylation and decreased ER-α, ERR-α, and HNF-4α in the rat liver
SO JOURNAL OF HEPATOLOGY
LA English
DT Article
DE Liver steatosis; Fatty acid oxidation; Folate; Cobalamin; Vitamin B12;
   PGC-1 alpha; Methylation; Epigenomics
ID ENDOPLASMIC-RETICULUM STRESS; ACTIVATED-RECEPTOR-ALPHA;
   INSULIN-RESISTANCE; HEPATIC STEATOSIS; MICE DEFICIENT; FIBROSIS;
   METABOLISM; FOLATE; SUPPLEMENTATION; STEATOHEPATITIS
AB Background & Aims: Folate and cobalamin are methyl donors needed for the synthesis of methionine, which is the precursor of S-adenosylmethionine, the substrate of methylation in epigenetic, and epigenomic pathways. Methyl donor deficiency produces liver steatosis and predisposes to metabolic syndrome. Whether impaired fatty acid oxidation contributes to this steatosis remains unknown.
   Methods: We evaluated the consequences of methyl donor deficient diet in liver of pups from dams subjected to deficiency during gestation and lactation.
   Results: The deprived rats had microvesicular steatosis, with increased triglycerides, decreased methionine synthase activity, S-adenosylmethionine, and S-adenosylmethionine/S-adenosylhomocysteine ratio. We observed no change in apoptosis markers, oxidant and reticulum stresses, and carnityl-palmitoyl transferase 1 activity, and a decreased expression of SREBP-1c. Impaired beta-oxidation of fatty acids and carnitine deficit were the predominant changes, with decreased free and total carnitines, increased C14:1/C16 acylcarnitine ratio, decrease of oxidation rate of palmitoyl-CoA and palmitoyl-L-carnitine and decrease of expression of novel organic cation transporter 1, acylCoA-dehydrogenase and trifunctional enzyme subunit alpha and decreased activity of complexes I and II. These changes were related to lower protein expression of ER-alpha, ERR-alpha and HNF-4 alpha, and hypomethylation of PGC-1 alpha co-activator that reduced its binding with PPAR-alpha, ERR-alpha, and HNF-4 alpha.
   Conclusions: The liver steatosis resulted predominantly from hypomethylation of PGC1-alpha, decreased binding with its partners and subsequent impaired mitochondrial fatty acid oxidation. This link between methyl donor deficiency and epigenomic deregulations of energy metabolism opens new insights into the pathogenesis of fatty liver disease, in particular, in relation to the fetal programming hypothesis. (C) 2012 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
C1 [Pooya, Shabnam; Blaise, Sebastien; Garcia, Maira Moreno; Alberto, Jean-Marc; Gueant-Rodriguez, Rosa-Maria; Jeannesson, Elise; Bressenot, Aude; Nicolas, Benedicte; Daval, Jean-Luc; Peyrin-Biroulet, Laurent; Bronowicki, Jean-Pierre; Gueant, Jean-Louis] Nancy Univ, Fac Med, INSERM, U954, Nancy, France.
   [Pooya, Shabnam; Blaise, Sebastien; Garcia, Maira Moreno; Alberto, Jean-Marc; Gueant-Rodriguez, Rosa-Maria; Jeannesson, Elise; Bressenot, Aude; Nicolas, Benedicte; Daval, Jean-Luc; Peyrin-Biroulet, Laurent; Bronowicki, Jean-Pierre; Gueant, Jean-Louis] Nancy Univ, CHU Nancy, Nancy, France.
   [Giudicelli, Jean] Univ Nice, Fac Med, INSERM, U907,IFR50, Nice, France.
   [Giudicelli, Jean] Univ Nice, CHU Nice, Nice, France.
   [Gueguen, Naig; Malthiery, Yves] Univ Angers, Angers, France.
   [Malthiery, Yves] Fac Med, Inserm 694, Angers, France.
   Fac Med, Inserm 771, Angers, France.
C3 Institut National de la Sante et de la Recherche Medicale (Inserm);
   Universite de Lorraine; Universite de Lorraine; CHU de Nancy; Institut
   National de la Sante et de la Recherche Medicale (Inserm); Universite
   Cote d'Azur; CHU Nice; Universite Cote d'Azur; Universite d'Angers;
   Institut National de la Sante et de la Recherche Medicale (Inserm);
   Universite d'Angers; Universite d'Angers; Institut National de la Sante
   et de la Recherche Medicale (Inserm)
RP Guéant, JL (corresponding author), Nancy Univ, Fac Med, INSERM, U954, Nancy, France.
EM jean-louis.gueant@medecine.uhp-nancy.fr
RI Guéant-Rodriguez, Rosa-Maria/ABK-8588-2022; BLAISE,
   Sebastien/AAS-1022-2020; Nielsen, Ole Haagen/AAK-2482-2021; Daval,
   Jean-Luc/G-6502-2014; Moreno, Maira/B-5387-2012
OI peyrin-biroulet, laurent/0000-0003-2536-6618; BLAISE,
   Sebastien/0000-0003-3012-1500
FU Region Lorraine; national agency for research (ANR Nutrivigene)
FX This study was supported by the Region Lorraine and by a grant from the
   national agency for research (ANR Nutrivigene).
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NR 42
TC 92
Z9 98
U1 0
U2 43
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0168-8278
EI 1600-0641
J9 J HEPATOL
JI J. Hepatol.
PD AUG
PY 2012
VL 57
IS 2
BP 344
EP 351
DI 10.1016/j.jhep.2012.03.028
PG 8
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 991EW
UT WOS:000307685300020
PM 22521344
DA 2025-06-11
ER

PT J
AU Larter, CZ
   Yeh, MM
   Van Rooyen, DM
   Brooling, J
   Ghatora, K
   Farrell, GC
AF Larter, Claire Z.
   Yeh, Matthew M.
   Van Rooyen, Derrick M.
   Brooling, John
   Ghatora, Kamaljit
   Farrell, Geoffrey C.
TI Peroxisome proliferator-activated receptor-α agonist, Wy 14 643,
   improves metabolic indices, steatosis and ballooning in diabetic mice
   with non-alcoholic steatohepatitis
SO JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
LA English
DT Article
DE adipose tissue; experimental; inflammation; monocyte chemoattractant
   protein 1; non-alcoholic fatty liver disease; non-alcoholic
   steatohepatitis experimental; peroxisome proliferator activated receptor
   alpha; steatosis
ID FATTY LIVER-DISEASE; KAPPA-B ACTIVATION; PPAR-ALPHA; INSULIN-RESISTANCE;
   NASH; INFLAMMATION; FENOFIBRATE; INJURY; MODEL; OBESE
AB Background and Aims: Lipid accumulation precedes hepatocellular injury and liver inflammation in non-alcoholic steatohepatitis (NASH). The peroxisome proliferator-activated receptor (PPAR)a regulates hepatic lipid disposal. We studied whether pharmacological stimulation of PPARa reverses NASH associated with metabolic syndrome in high-fat (HF)-fed foz/foz obese/diabetic mice. Methods: Female foz/foz mice and wildtype (WT) littermates were fed HF diet for 16 weeks to initiate NASH then treated withWy 14 643 (Wy) for 10 days or 20 days. Liver disease was assessed by histology, serum alanine aminotransferase, genes (real-time polymerase chain reaction) and proteins (Western blot, enzyme-linked immunosorbent assay) of interest and pro-inflammatory signaling pathways were determined. Results: In diabetic foz/foz mice, NASH was associated with elevated serum MCP1 and hepatic activation of nuclear factor (NF)-kappa B and c-Jun N-terminal kinase, but not oxidative or endoplasmic reticulum stress. Wy treatment decreased steatosis and injury, although induction of PPARa-responsive fatty acid oxidation genes was proportionally less than in WT. The PPARa agonist lowered serum insulin, corrected hyperglycemia, and suppressed the carbohydrate-dependent lipogenic transcription factor, carbohydrate response element binding protein. Steatosis resolution was associated with suppression of NF-kB and JNK activation and decreased hepatic macrophages and neutrophils. Despite this, histology inflammation score remained high, associated with serum monocyte chemoattractant protein (MCP) 1 elevation, a pro-inflammatory chemokine related to higher adipose, not liver MCP1 mRNA expression. Conclusions: Pharmacological activation of PPARa improves metabolic milieu, steatosis, ballooning, and combats NF-kB and JNK activation, neutrophil and F4/80 macrophage recruitment in diabetes-related NASH. However, persistent liver inflammation with high serum MCP1 due to unsuppressed adipose inflammation may limit PPARa agonists' efficacy as therapy for NASH.
C1 [Larter, Claire Z.; Van Rooyen, Derrick M.; Brooling, John; Ghatora, Kamaljit; Farrell, Geoffrey C.] Canberra Hosp, ANU Med Sch, Liver Res Grp, Garran, ACT, Australia.
   [Yeh, Matthew M.] Univ Washington, Med Ctr, Dept Pathol, Seattle, WA 98195 USA.
C3 Australian National University; Canberra Hospital; University of
   Washington; University of Washington Seattle
RP Farrell, GC (corresponding author), POB 11, Woden, ACT 2606, Australia.
EM geoff.farrell@anu.edu.au
FU Australian National Health and Medical Research Council (NHMRC)
   [418101]; NHMRC [525473, 585539]
FX The authors would like to acknowledge helpful discussions with Dr
   Isabelle Leclercq and expert assistance from Dr Deborah Heydet. This
   work was funded by the Australian National Health and Medical Research
   Council (NHMRC) project grant 418101. C. Z. L. was funded by NHMRC
   Australian Biomedical Training Fellowship 525473, and D. V. R. by NHMRC
   scholarship 585539.
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NR 24
TC 74
Z9 82
U1 0
U2 11
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0815-9319
J9 J GASTROEN HEPATOL
JI J. Gastroenterol. Hepatol.
PD FEB
PY 2012
VL 27
IS 2
BP 341
EP 350
DI 10.1111/j.1440-1746.2011.06939.x
PG 10
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 879NJ
UT WOS:000299336400025
PM 21929649
DA 2025-06-11
ER

PT J
AU Monroy-Cárdenas, M
   Almarza, C
   Valenzuela-Hormázabal, P
   Ramírez, D
   Urra, FA
   Martínez-Cifuentes, M
   Araya-Maturana, R
AF Monroy-Cardenas, Matias
   Almarza, Cristopher
   Valenzuela-Hormazabal, Paulina
   Ramirez, David
   Urra, Felix A.
   Martinez-Cifuentes, Maximiliano
   Araya-Maturana, Ramiro
TI Identification of Antioxidant Methyl Derivatives of
   Ortho-Carbonyl Hydroquinones That Reduce Caco-2 Cell Energetic
   Metabolism and Alpha-Glucosidase Activity
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE hydroquinones; methyl derivatives; antioxidants; diabetes; DFT; docking
ID MITOCHONDRIAL BIOENERGETICS; INTESTINAL BARRIER; DIABETES-MELLITUS;
   ACCURATE DOCKING; PROTEIN; GLIDE; FLAVONOIDS; MODEL
AB alpha-glucosidase, a pharmacological target for type 2 diabetes mellitus (T2DM), is present in the intestinal brush border membrane and catalyzes the hydrolysis of sugar linkages during carbohydrate digestion. Since alpha-glucosidase inhibitors (AGIs) modulate intestinal metabolism, they may influence oxidative stress and glycolysis inhibition, potentially addressing intestinal dysfunction associated with T2DM. Herein, we report on a study of an ortho-carbonyl substituted hydroquinone series, whose members differ only in the number and position of methyl groups on a common scaffold, on radical-scavenging activities (ORAC assay) and correlate them with some parameters obtained by density functional theory (DFT) analysis. These compounds' effect on enzymatic activity, their molecular modeling on alpha-glucosidase, and their impact on the mitochondrial respiration and glycolysis of the intestinal Caco-2 cell line were evaluated. Three groups of compounds, according their effects on the Caco-2 cells metabolism, were characterized: group A (compounds 2, 3, 5, 8, 9, and 10) reduces the glycolysis, group B (compounds 1 and 6) reduces the basal mitochondrial oxygen consumption rate (OCR) and increases the extracellular acidification rate (ECAR), suggesting that it induces a metabolic remodeling toward glycolysis, and group C (compounds 4 and 7) increases the glycolysis lacking effect on OCR. Compounds 5 and 10 were more potent as alpha-glucosidase inhibitors (AGIs) than acarbose, a well-known AGI with clinical use. Moreover, compound 5 was an OCR/ECAR inhibitor, and compound 10 was a dual agent, increasing the proton leak-driven OCR and inhibiting the maximal electron transport flux. Additionally, menadione-induced ROS production was prevented by compound 5 in Caco-2 cells. These results reveal that slight structural variations in a hydroquinone scaffold led to diverse antioxidant capability, alpha-glucosidase inhibition, and the regulation of mitochondrial bioenergetics in Caco-2 cells, which may be useful in the design of new drugs for T2DM and metabolic syndrome.
C1 [Monroy-Cardenas, Matias] Pontificia Univ Catolica Chile, Escuela Quim, Fac Quim & Farm, Ave Vicuna Mackenna 4860, Santiago 7820436, Chile.
   [Monroy-Cardenas, Matias; Almarza, Cristopher; Urra, Felix A.; Araya-Maturana, Ramiro] Univ Talca, MIBI Interdisciplinary Grp Mitochondrial Targetin, POB 747, Talca 3460000, Chile.
   [Almarza, Cristopher; Urra, Felix A.] Network Snake Venom Res & Drug Discovery, Ave Independencia 1027, Santiago 7810000, Chile.
   [Almarza, Cristopher; Urra, Felix A.] Univ Chile, Inst Biomed Sci, Fac Med, Mol & Clin Pharmacol Program,Metab Plast & Bioener, Ave Independencia 1027, Santiago 7810000, Chile.
   [Valenzuela-Hormazabal, Paulina; Ramirez, David] Univ Concepcion, Fac Ciencias Biol, Dept Farmacol, Concepcion 4030000, Chile.
   [Martinez-Cifuentes, Maximiliano] Univ Concepcion, Fac Ciencias Quim, Dept Quim Organ, Edmundo Larenas 129, Concepcion 4070371, Chile.
   [Araya-Maturana, Ramiro] Univ Talca, Inst Quim Recursos Nat, Talca 3460000, Chile.
C3 Pontificia Universidad Catolica de Chile; Universidad de Talca;
   Universidad de Chile; Universidad de Concepcion; Universidad de
   Concepcion; Universidad de Talca
RP Araya-Maturana, R (corresponding author), Univ Talca, MIBI Interdisciplinary Grp Mitochondrial Targetin, POB 747, Talca 3460000, Chile.; Martínez-Cifuentes, M (corresponding author), Univ Concepcion, Fac Ciencias Quim, Dept Quim Organ, Edmundo Larenas 129, Concepcion 4070371, Chile.; Araya-Maturana, R (corresponding author), Univ Talca, Inst Quim Recursos Nat, Talca 3460000, Chile.
EM c.chavez.bio@gmail.com; felixurraf@uchile.cl; raraya@utalca.cl
RI Ramirez, David/HRE-0888-2023; MartÃ­nez-Cifuentes,
   Maximiliano/GQH-4400-2022; Araya-Maturana, Ramiro/N-8747-2015; Martinez
   Cifuentes, Maximiliano/F-9353-2015; Ramirez, David/Q-9537-2018
OI Martinez Cifuentes, Maximiliano/0000-0003-2959-3164; Monroy-Cardenas,
   Matias/0009-0005-3694-5086; Araya-Maturana, Ramiro/0000-0002-5082-9146;
   Ramirez, David/0000-0003-0002-1189; Valenzuela-Hormazabal,
   Paulina/0009-0008-6110-1573; Chavez, Cristopher
   Almarza/0009-0009-8861-806X
FU Fondecyt [3240227, 1241547, 1221874, 1220656]; ANID Anillo [ACT210097];
   FONDEQUIP [EQM220164]; VID-UChile [UM-03/22]; VRID-UDEC [2023000771INV]
FX This research was funded by Fondecyt grant number 3240227, 1241547,
   1221874, 1220656;ANID Anillo grant number ACT210097; FONDEQUIP grant
   number EQM220164; VID-UChile grantnumber UM-03/22 and VRID-UDEC grant
   number 2023000771INV
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NR 71
TC 2
Z9 2
U1 1
U2 7
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD AUG
PY 2024
VL 25
IS 15
AR 8334
DI 10.3390/ijms25158334
PG 17
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA C2N7L
UT WOS:001287780900001
PM 39125904
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Ren, YL
   Feng, Y
   Qing, J
   Zhang, P
   Xiao, L
   Liang, XH
AF Ren, Yanling
   Feng, Ye
   Qing, Jun
   Zhang, Ping
   Xiao, Lun
   Liang, Xiaohua
TI The correlation between nuts and algae-less diet and children's blood
   pressure: from a cross-sectional study in Chongqing
SO CLINICAL AND EXPERIMENTAL HYPERTENSION
LA English
DT Article
DE Nuts; algae; dietary patterns; blood pressure; hypertension
ID METABOLIC SYNDROME; HYPERTENSION; RISK; ATHEROSCLEROSIS; CHILDHOOD;
   SUPPORT; STRESS; SEX
AB Background Nuts and algae have been shown to improve BP levels, but their effectiveness is controversial. Aims This study aims to illustrate the effect of dietary pattern with nuts and algae-less on BP levels in children and adolescents from a cross-sectional study. Methods A total of 5645 children from the Chongqing Children's Health Cohort, aged 9.34 +/- 1.74 years with 52.05% males, were analyzed. Stratified analysis was conducted to explore the differences between the two dietary patterns in urban or rural areas, as well as the differences in different gender. Logistic regression was used to analyze the influence factors of increased BP. And a GLM was used to analyze the influence of the two dietary patterns on systolic blood pressure (SBP, mmHg), diastolic blood pressure (DBP, mmHg), and mean arterial pressure (MAP, mmHg). Results Children with nuts and algae-less dietary patterns had higher SBP (104.68 +/- 10.31 vs 103.81 +/- 9.74, P = .006), DBP (64.27 +/- 7.53 vs 63.55 +/- 7.52, P = .002), and MAP (77.74 +/- 7.75 vs 76.97 +/- 7.52, P = .001) compared with those children with a balanced diet. After adjusting for covariates, the nuts and algae-less diet was a risk factor for hypertension in children when compared with the balanced diet(OR(95%CI):1.455(1.097,1.930), P = .009). The nuts and algae-less diet has a significant influence on SBP (104.68 +/- 10.31 mmHg vs.103.81 +/- 9.74 mmHg, P = .006). Stratified analysis by sex showed that nuts and algae-less dietary patterns had a more significant impact on females than males. Conclusion Nuts and algae-less dietary pattern correlated with increased BP levels in children, and a greater impact on SBP levels was found in females, suggesting that a balanced diet with appropriate nuts and algae should be proposed for children in China.
C1 [Ren, Yanling; Feng, Ye; Zhang, Ping; Liang, Xiaohua] Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders, China Int Sci & Technol Cooperat Ctr Child Dev & C, Minist Educ,Key Lab Child Dev & Disorders,Children, Chongqing, Peoples R China.
   [Qing, Jun; Xiao, Lun] Ctr Dis Control & Prevent Jiulongpo Dist, Chongqing, Peoples R China.
   [Liang, Xiaohua] Childrens Hosp Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders, China Int Sci & Technol Cooperat Ctr Child Dev & C, Minist Educ,Key Lab Child Dev & Disorders,Children, 136 2nd St, Chongqing 400014, Peoples R China.
C3 Chongqing Medical University; Ministry of Education - China; Chongqing
   Medical University; Ministry of Education - China
RP Liang, XH (corresponding author), Childrens Hosp Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders, China Int Sci & Technol Cooperat Ctr Child Dev & C, Minist Educ,Key Lab Child Dev & Disorders,Children, 136 2nd St, Chongqing 400014, Peoples R China.
EM liangxiaohua666@sina.com
RI Liang, Xiaohua/ADJ-8830-2022
OI liang, xiaohua/0000-0003-3867-9779
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NR 54
TC 2
Z9 2
U1 0
U2 21
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1064-1963
EI 1525-6006
J9 CLIN EXP HYPERTENS
JI Clin. Exp. Hypertens.
PD DEC 31
PY 2023
VL 45
IS 1
AR 2180024
DI 10.1080/10641963.2023.2180024
PG 9
WC Pharmacology & Pharmacy; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Cardiovascular System & Cardiology
GA 9H0FE
UT WOS:000938516900001
PM 36823777
OA gold
DA 2025-06-11
ER

PT J
AU Pugliese, NR
   Mazzola, M
   Madonna, R
   Gargani, L
   De Biase, N
   Dini, FL
   Taddei, S
   De Caterina, R
   Masi, S
AF Pugliese, Nicola Riccardo
   Mazzola, Matteo
   Madonna, Rosalinda
   Gargani, Luna
   De Biase, Nicolo
   Dini, Frank L.
   Taddei, Stefano
   De Caterina, Raffale
   Masi, Stefano
TI Exercise-induced pulmonary hypertension in HFpEF and HFrEF: Different
   pathophysiologic mechanism behind similar functional impairment
SO VASCULAR PHARMACOLOGY
LA English
DT Article
DE Heart failure; Heart failure with preserved ejection fraction;
   Echocardiography; Cardiopulmonary exercise test; Exercise-induced
   pulmonary hypertension
ID HEART-FAILURE; COMBINED CARDIOPULMONARY; NONINVASIVE ASSESSMENT;
   CONTRACTILE FUNCTION; ECHOCARDIOGRAPHY; PHENOTYPES; SEVERITY; PRESSURE;
   ADULTS
AB Aims: Pathophysiological mechanisms behind cardio-pulmonary impairment in heart failure (HF) with reduced (HFrEF) and preserved (HFpEF) ejection fraction are likely different. We analysed them using combined cardiopulmonary-exercise stress echocardiography (CPET-ESE).& nbsp;& nbsp;Methods: We matched 1:1 subjects with HFrEF (n = 90) and HFpEF (n = 90) for age, sex, body mass index (BMI), peak oxygen consumption, and minute ventilation/carbon dioxide production slope. All patients underwent a symptom-limited graded ramp bicycle CPET-ESE compared with 40 age-, sex-and BMI-matched healthy controls.& nbsp;Results: During a median follow-up of 25 months, we observed 22 deaths and 80 HF hospitalisations, with similar distribution between HFpEF and HFrEF. Compared with HFrEF, HFpEF had a higher prevalence of metabolic syndrome (p = 0.02) with higher levels of high-sensitivity C-reactive protein and uric acid (p < 0.01). The multipoint mean pulmonary artery pressure/cardiac output (mPAP/CO) slope showed equally increased values in HFrEF and HFpEF (3.5 & PLUSMN; 1.8 and 3.7 & PLUSMN; 1.5 mmHg/L/min) compared with controls (1.8 & PLUSMN; 1.1 mmHg/L/min; p < 0.0001). During exercise, HFpEF displayed more adverse interaction of right ventricle-pulmonary artery (RV PA; tricuspid annular plane systolic excursion/systolic pulmonary artery pressure: 0.40 +/- 0.2 vs 0.47 +/- 0.2 mm/ mmHg in HFrEF; p < 0.01) and left atrium-left ventricle (LA-LV; LA reservoir strain/LV global longitudinal strain: 1.5 +/- 0.8 vs 2.2 +/- 1.1 in HFrEF; p < 0.01). The latter were independent predictors of mPAP/CO slope, along with hs-CRP (adjusted R-2: 0.21; p < 0.0001).& nbsp;Conclusion: Despite similar disease severity, HFpEF and HFrEF show different pathophysiological mechanisms. HFpEF is characterised by a worse LA-LV and RV-PA interaction than HFrEF, with more prevalent low-grade systemic inflammation. In HFpEF, these features may have a role in exercise-induced pulmonary hypertension.
C1 [Pugliese, Nicola Riccardo; De Biase, Nicolo; Taddei, Stefano; Masi, Stefano] Univ Pisa, Dept Clin & Expt Med, Pisa, Italy.
   [Mazzola, Matteo; Madonna, Rosalinda; De Caterina, Raffale] Univ Pisa, Azienda Osped Univ Pisana, Dept Pathol, Cardiol Div, Pisa, Italy.
   [Gargani, Luna] Inst Clin Physiol CNR, Pisa, Italy.
   [Dini, Frank L.] Ctr Med St Agostino, Milan, Italy.
C3 University of Pisa; University of Pisa; Azienda Ospedaliero
   Universitaria Pisana; Consiglio Nazionale delle Ricerche (CNR)
RP De Caterina, R (corresponding author), Azienda Osped Univ Pisana, Cattedra Malattie DellApparat Cardiovascolare, Dipartimento Cardiotoracovasc, UOC Cardiol Univ 1, Pisa, Italy.
EM raffaele.decaterina@unipi.it
RI De Biase, Nicolò/AAA-1609-2022; Mazzola, Matteo/HPC-2331-2023; Pugliese,
   Nicola/J-9295-2019; Gargani, Luna/C-6187-2015
OI Madonna, Rosalinda/0000-0001-6455-2777; Mazzola,
   Matteo/0000-0001-7463-4311; De Biase, Nicolo/0000-0001-9133-5217;
   Gargani, Luna/0000-0002-0716-453X
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NR 51
TC 17
Z9 17
U1 0
U2 5
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1537-1891
EI 1879-3649
J9 VASC PHARMACOL
JI Vasc. Pharmacol.
PD JUN
PY 2022
VL 144
AR 106978
DI 10.1016/j.vph.2022.106978
EA MAR 2022
PG 9
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 1D0NO
UT WOS:000793507200008
PM 35301117
DA 2025-06-11
ER

PT J
AU La Sala, L
   Tagliabue, E
   Mrakic-Sposta, S
   Uccellatore, AC
   Senesi, P
   Terruzzi, I
   Trabucchi, E
   Rossi-Bernardi, L
   Luzi, L
AF La Sala, Lucia
   Tagliabue, Elena
   Mrakic-Sposta, Simona
   Uccellatore, Anna Chiara
   Senesi, Pamela
   Terruzzi, Ileana
   Trabucchi, Emilio
   Rossi-Bernardi, Luigi
   Luzi, Livio
TI Lower miR-21/ROS/HNE levels associate with lower glycemia after
   habit-intervention: DIAPASON study 1-year later
SO CARDIOVASCULAR DIABETOLOGY
LA English
DT Article
DE Dysglycemia; Prediabetes; microRNA-21; miR-21; ROS; Hydroxynonenal;
   Habit-intervention; Mediterranean diet; Glucose monitoring
ID IMPAIRED GLUCOSE-TOLERANCE; GENOME-WIDE ASSOCIATION; LIFE-STYLE
   INTERVENTION; ENDOTHELIAL DYSFUNCTION; OSCILLATING GLUCOSE; METABOLIC
   SYNDROME; DIABETES-MELLITUS; OXIDATIVE STRESS; RISK-SCORE; TYPE-2
AB Background The prevalence of prediabetes is increasing in the global population and its metabolic derangements may expose to a higher risk to develop type 2 diabetes (T2D) and its cardiovascular burden. Lifestyle modifications might have considerable benefits on ameliorating metabolic status. Alternative biomarkers, such as circulating miR-21, has been recently discovered associated with dysglycemia. Here we evaluated, in a longitudinal cohort of dysglycemic population the relation between the circulating miR-21/ROS/HNE levels and the habit-intervention (HI) after 1 year of follow-up. Methods 1506 subjects from DIAPASON study were screened based on the Findrisc score. Of them, 531 subjects with Findrisc >= 9 were selected for dysglycemia (ADA criteria) and tested for circulating miR-21, ROS and HNE levels, as damaging-axis. 207 subjects with dysglycemia were re-evaluated after 1-year of habit intervention (HI). Repeated measures tests were used to evaluate changes from baseline to 1-year of follow-up. The associations between glycemic parameters and miR-21/ROS/HNE were implemented by linear regression and logistic regression models. Results After HI, we observed a significant reduction of miR-21/ROS/HNE axis in dysglycemic subjects, concomitantly with ameliorating of metabolic parameters, including insulin resistance, BMI, microalbuminuria, reactive hyperemia index and skin fluorescence. Significant positive interaction was observed between miR-21 axis with glycaemic parameters after HI. Lower miR-21 levels after HI, strongly associated with a reduction of glycemic damaging-axis, in particular, within-subjects with values of 2hPG < 200 mg/dL. Conclusions Our findings demonstrated that HI influenced the epigenetic changes related to miR-21 axis, and sustain the concept of reversibility from dysglycemia. These data support the usefulness of novel biological approaches for monitoring glycemia as well as provide a screening tool for preventive programmes.
C1 [La Sala, Lucia; Tagliabue, Elena; Senesi, Pamela; Terruzzi, Ileana; Trabucchi, Emilio; Luzi, Livio] IRCCS, MultiMed, PST Via Fantoli 16-15, I-20138 Milan, MI, Italy.
   [Mrakic-Sposta, Simona] Natl Res Council CNR, Inst Clin Physiol, I-20162 Milan, Italy.
   [Uccellatore, Anna Chiara] ICCS Ist Clin Citta, Milan, Italy.
   [Senesi, Pamela; Terruzzi, Ileana; Luzi, Livio] Univ Milan, Dept Biomed Sci Hlth, Milan, Italy.
C3 Consiglio Nazionale delle Ricerche (CNR); Istituto di Fisiologia Clinica
   (IFC-CNR); University of Milan
RP La Sala, L (corresponding author), IRCCS, MultiMed, PST Via Fantoli 16-15, I-20138 Milan, MI, Italy.
EM lucia.lasala@multimedica.it
RI Mrakic-Sposta, Simona/AAA-2991-2019; Senesi, Pamela/AAA-5678-2019; La
   Sala, Lucia/A-4467-2019; Terruzzi, Ileana/AAA-9737-2019
OI Terruzzi, Ileana/0000-0002-8663-4033
FU Fondazione Romeo ad Enrica Invernizzi -Milano; European Study for the
   Study of Diabetes (EFSD) as European Research Grant Award (EFSD/Sanofi
   programme); Italian Ministry of Health "Ricerca Corrente" grant
FX DIAPASON study was supported by the Fondazione Romeo ad Enrica
   Invernizzi -Milano. This research was supported by a research grant
   award from European Study for the Study of Diabetes (EFSD) as European
   Research Grant Award (EFSD/Sanofi programme, whose recipient was LLS)
   and by the Italian Ministry of Health "Ricerca Corrente" grant to IRCCS
   MultiMedica. The funders had no role in the design and conduct of the
   study, collection, management, analysis, and interpretation of the data,
   preparation, review, and approval of the manuscript, or the decision to
   submit the manuscript for publication.
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NR 57
TC 8
Z9 8
U1 0
U2 2
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1475-2840
J9 CARDIOVASC DIABETOL
JI Cardiovasc. Diabetol.
PD MAR 4
PY 2022
VL 21
IS 1
AR 35
DI 10.1186/s12933-022-01465-0
PG 13
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism
GA ZN0MW
UT WOS:000764740500001
PM 35246121
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Pallauf, K
   Günther, I
   Kühn, G
   Chin, D
   de Pascual-Teresa, S
   Rimbach, G
AF Pallauf, Kathrin
   Guenther, Ilka
   Kuehn, Gianna
   Chin, Dawn
   de Pascual-Teresa, Sonia
   Rimbach, Gerald
TI The Potential of Resveratrol to Act as a Caloric Restriction Mimetic
   Appears to Be Limited: Insights from Studies in Mice
SO ADVANCES IN NUTRITION
LA English
DT Review
DE sirtuin; polyphenol; healthspan; diabetes mellitus type II; lunularin;
   dihydroresveratol
ID EXTENDS LIFE-SPAN; METABOLIC SYNDROME; TRANS-RESVERATROL;
   GLUCOSE-HOMEOSTASIS; INSULIN SENSITIVITY; OXIDATIVE STRESS;
   GENE-EXPRESSION; OLDER-ADULTS; RISK-FACTORS; METAANALYSIS
AB Caloric restriction (CR) has been shown repeatedly to prolong the lifespan in laboratory animals, with its benefits dependent on molecular targets forming part of the nutrient signaling network, including the NAD-dependent deacetylase silent mating type information regulation 2 homologue 1 (SIRT1). It has been hypothesized that the stilbene resveratrol (RSV) may counteract age- and obesity-related diseases similarly to CR. In yeast and worms, RSV promoted longevity also depended on SIRT1. While it remains unclear whether RSV can prolong lifespans in mammals, some studies in rodents supplemented with RSV have reported lowered body weight (BW) and fat mass, improved insulin sensitivity, lowered cholesterol levels, increased fitness, and mitochondrial biogenesis. Molecular mechanisms possibly leading to such changes include altered gene transcription and activation of SIRT1, AMP-activated kinase (AMPK), and peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A). However, some mouse models did not benefit from RSV treatment to the same extent as others. We conducted a literature search on PubMed (15 April, 2020) for trials directly comparing RSV application to CR feeding in mice. In most studies retrieved by this systematic PubMed search, mice supplemented with RSV did not show significant reductions of BW, glucose, or insulin. Moreover, in some of these studies, RSV and CR treatments affected molecular targets differently and/or findings on RSV and CR impacts varied between trials. We discuss those RSV-induced changes in gene transcription hypothesized to partly counteract age-related alterations. Although there may be a moderate effect of RSV supplementation on parameters such as insulin sensitivity toward a more CR like profile in mice, data are inconsistent. Likewise, RSV supplementation trials in humans , port controversial findings.While we consider that RSV may, under certain circumstances, moderately mimic some aspects of CR, current evidence does not fully support its use to prevent or treat age- or obesity-related diseases.
C1 [Pallauf, Kathrin; Guenther, Ilka; Kuehn, Gianna; Chin, Dawn; Rimbach, Gerald] Univ Kiel, Inst Human Nutr & Food Sci, Kiel, Germany.
   [de Pascual-Teresa, Sonia] CSIC, Dept Metab & Nutr, Inst Food Sci Technol & Nutr ICTAN, Madrid, Spain.
C3 University of Kiel; Consejo Superior de Investigaciones Cientificas
   (CSIC); CSIC - Instituto de Ciencia y Tecnologia de Alimentos y
   Nutricion (ICTAN)
RP Pallauf, K (corresponding author), Univ Kiel, Inst Human Nutr & Food Sci, Kiel, Germany.
EM pallauf@foodsci.uni-kiel.de
RI Pallauf, Kathrin/Z-5966-2019; Rimbach, Gerald/A-7178-2011; de
   Pascual-Teresa, Sonia/F-5321-2011
OI de Pascual-Teresa, Sonia/0000-0001-8546-8507; Rimbach,
   Gerald/0000-0001-7888-4684; Pallauf, Kathrin/0000-0002-7223-2738
FU German Research Foundation Deutsche Forschungsgemeinschaft [274521263]
FX The project was funded by the German Research Foundation Deutsche
   Forschungsgemeinschaft (project number 274521263).
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NR 109
TC 9
Z9 9
U1 1
U2 16
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 2161-8313
EI 2156-5376
J9 ADV NUTR
JI Adv. Nutr.
PD MAY
PY 2021
VL 12
IS 3
BP 995
EP 1005
DI 10.1093/advances/nmaa148
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA SS0XE
UT WOS:000661465200029
PM 33271594
OA Green Published, Bronze, Green Submitted
DA 2025-06-11
ER

PT J
AU Zhao, C
   Zhu, L
   Li, RJ
   Wang, HL
   Cai, ZW
AF Zhao, Chao
   Zhu, Lin
   Li, Ruijin
   Wang, Hailin
   Cai, Zongwei
TI Omics approach reveals metabolic disorders associated with the
   cytotoxicity of airborne particulate matter in human lung carcinoma
   cells
SO ENVIRONMENTAL POLLUTION
LA English
DT Article
DE Metabolomics; Lipidomics; Proteomics; LC-MS/MS; Human lung carcinoma
   cells
ID AIR-POLLUTION; OXIDATIVE STRESS; SPLICING REGULATION; DNA-DAMAGE;
   CERAMIDE; PROTEIN; EXPOSURE; TRAFFICKING; PM2.5; EXACERBATIONS
AB Exposure to airborne particulate matter (PM) (2.5) induced various adverse health effects, such as metabolic syndrome, systemic inflammation and respiratory infection. However, a global influence of PM2.5-induced metabolic and proteomic disorders remains confusing, and the underlying mechanism is still under-explored. Herein, LC-MS/MS-based metabolomics, lipidomics and isobaric tags for relative and absolute quantification (iTRAQ)-based proteomics were applied to analyze the toxicological characteristics of PM2.5 from Taiyuan City in China (Taiyuan-PM2.5) on human lung carcinoma cells (A549) after the 24-h treatment. Metabolites, lipids and proteins that have distinctive differences were screened by SIEVE, LipidSearch and Proteome Discoverer, respectively. The abundance of 56 metabolites (40 increased and 16 decreased), 22 lipids (19 increased and 3 decreased) and 81 proteins (55 up-regulated and 26 down-regulated) were significantly changed upon the PM2.5 treatment Among the proteomics analysis, 16 proteins were specifically related to RNA splicing, mainly including up-regulated serine/arginine-rich splicing factor 1 (SRSFI), SRSF2, small nuclear ribonucleoprotein 70 kDa (snRNP70), small nuclear ribonucleoprotein polypeptide B (SNRPB), SNRPC, SNRPE and down-regulated heterogeneous nuclear ribonucleoprotein U-like 2 (hnRNP UL2). At the metabolic level, PM2.5 exposure significantly altered the sphingolipid metabolism, including ceramide, serine, sphingosine and sphingomyelin. It was proposed that excessive accumulation of ceramide and expression of key enzymes (ceramide synthases, phingomyelinase, sphingosine kinase types 2 and protein phosphatase-1) induced the secretion of pro inflammatory cytokines, generation of lipotoxicity and alterations of RNA splicing in PM2.5-treated A549 cells. In general, our results demonstrated that ceramide accumulation and altered RNA splicing could becritical contributors to PM2.5-induced cytotoxicity at metabolic and proteomic level, which might be considered as potential markers for toxicological evaluation of PM2.5 samples. (C) 2018 Elsevier Ltd. All rights reserved.
C1 [Zhao, Chao; Zhu, Lin; Cai, Zongwei] Hong Kong Baptist Univ, Dept Chem, State Key Lab Environm & Biol Anal, Hong Kong, Peoples R China.
   [Zhao, Chao; Wang, Hailin] Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing, Peoples R China.
   [Li, Ruijin] Shanxi Univ, Inst Environm Sci, Taiyuan, Shanxi, Peoples R China.
C3 Hong Kong Baptist University; Chinese Academy of Sciences; Research
   Center for Eco-Environmental Sciences (RCEES), CAS; Shanxi University
RP Cai, ZW (corresponding author), Hong Kong Baptist Univ, Dept Chem, State Key Lab Environm & Biol Anal, Hong Kong, Peoples R China.
EM zwcai@hkbu.edu.hk
RI Zhao, Chao/AAP-9954-2021; Cai, Zongwei/ABD-4001-2020; Zhu,
   Lin/ADP-1657-2022
OI Zhu, Lin/0000-0002-2801-3626; Zhao, Chao/0000-0002-1765-6423; Cai,
   Zongwei/0000-0002-8724-7684
FU National Natural Science Foundation of China [21507106, 21705137,
   91543202]
FX The work was supported by the grants from the National Natural Science
   Foundation of China [No. 21507106, 21705137, 91543202].
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NR 50
TC 31
Z9 32
U1 0
U2 121
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0269-7491
EI 1873-6424
J9 ENVIRON POLLUT
JI Environ. Pollut.
PD MAR
PY 2019
VL 246
BP 45
EP 52
DI 10.1016/j.envpol.2018.11.108
PG 8
WC Environmental Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology
GA HK8EL
UT WOS:000458222100006
PM 30529940
DA 2025-06-11
ER

PT J
AU Violi, F
   Loffredo, L
   Pignatelli, P
   Angelico, F
   Bartimoccia, S
   Nocella, C
   Cangemi, R
   Petruccioli, A
   Monticolo, R
   Pastori, D
   Carnevale, R
AF Violi, F.
   Loffredo, L.
   Pignatelli, P.
   Angelico, F.
   Bartimoccia, S.
   Nocella, C.
   Cangemi, R.
   Petruccioli, A.
   Monticolo, R.
   Pastori, D.
   Carnevale, R.
TI Extra virgin olive oil use is associated with improved post-prandial
   blood glucose and LDL cholesterol in healthy subjects
SO NUTRITION & DIABETES
LA English
DT Article
ID MEDITERRANEAN DIETS; METABOLIC SYNDROME; OXIDATIVE STRESS; INHIBITION;
   TOLERANCE
AB OBJECTIVES: Extra virgin olive oil (EVOO) is a key component of the Mediterranean diet and seems to account for the protective effect against cardiovascular disease. However, the underlying mechanism is still elusive.
   DESIGN: We tested the effect of EVOO, added to Mediterranean-type meal, on post-prandial glycemic and lipid profile.
   SUBJECTS: Post-prandial glycemic and lipid profile were investigated in 25 healthy subjects who were randomly allocated in a cross-over design to a Mediterranean-type meal added with or without 10 g EVOO (first study), or Mediterranean-type meal with EVOO (10 g) or corn oil (10 g; second study). Glycemic profile, which included glucose, insulin, dipeptidyl-peptidase-4 (DPP-4)protein and activity, glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), and lipid profile, which included, low-density lipoprotein (LDL) cholesterol (LDL-C), oxidized LDL (ox-LDL), triglycerides and high-density lipoprotein (HDL) cholesterol (HDL-C), were analyzed before and 2 h after the meal.
   RESULTS: In the first study, 2 h after meal, subjects who assumed a meal with EVOO had significantly lower blood glucose (P<0.001), DPP-4 protein (P<0.001) and activity (P<0.001), LDL-C (P<0.001) and ox-LDL (P<0.001) and higher insulin (P<0.05), GLP-1 (P<0.001) and GIP (P<0.05) compared with those without EVOO. The second study showed that compared with corn oil, EVOO improved both glycemic and lipid profile. Thus, a significantly smaller increase of glucose (P<0.05), DPP4 protein (P<0.001) and activity (P<0.05) and higher increase of insulin (P<0.001) and GLP-1 (P<0.001) were observed. Furthermore, compared with corn oil, EVOO showed a significantly less increase of LDL-C (P<0.05) and ox-LDL (P<0.001).
   CONCLUSIONS: We report for the first time that EVOO improves post-prandial glucose and LDL-C, an effect that may account for the antiatherosclerotic effect of the Mediterranean diet.
C1 [Violi, F.; Loffredo, L.; Pignatelli, P.; Bartimoccia, S.; Nocella, C.; Cangemi, R.; Pastori, D.; Carnevale, R.] Univ Roma La Sapienza, Dept Internal Med & Med Specialties, I-00161 Rome, Italy.
   [Angelico, F.] Univ Roma La Sapienza, Dept Publ Hlth & Infect Dis, I-00161 Rome, Italy.
   [Petruccioli, A.] Policlin Umberto 1, AFC Patrimonio Serv & Furniture UO Ristoraz, Rome, Italy.
   [Monticolo, R.; Carnevale, R.] Univ Roma La Sapienza, Dept Med Surg Sci & Biotechnol, Latina, Italy.
C3 Sapienza University Rome; Sapienza University Rome; Sapienza University
   Rome; University Hospital Sapienza Rome; Sapienza University Rome
RP Violi, F (corresponding author), Univ Roma La Sapienza, Dept Internal Med & Med Specialties, I-00161 Rome, Italy.
EM francesco.violi@uniroma1.it
RI Corazza, Gino/K-8500-2016; Angelico, Francesco/AAB-6585-2020; Carnevale,
   Roberto/K-1472-2016; Violi, Francesco/K-1509-2016; nocella,
   cristina/K-2175-2016; pastori, daniele/J-7087-2016; pignatelli,
   pasquale/K-2116-2016; Loffredo, Lorenzo/K-4873-2016; Bartimoccia,
   Simona/K-7873-2016
OI Carnevale, Roberto/0000-0002-6216-9595; Cangemi,
   Roberto/0000-0002-4097-2061; Violi, Francesco/0000-0002-6610-7068;
   nocella, cristina/0000-0003-4398-6327; pastori,
   daniele/0000-0001-6357-5213; pignatelli, pasquale/0000-0002-2265-7455;
   Loffredo, Lorenzo/0000-0002-6542-6235; Bartimoccia,
   Simona/0000-0002-6266-3059
CR [Anonymous], 2014, PLOS ONE, DOI DOI 10.1371/journal.pone.0103246
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NR 19
TC 81
Z9 86
U1 0
U2 11
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 2044-4052
J9 NUTR DIABETES
JI Nutr. Diabetes
PD JUL 20
PY 2015
VL 5
AR e172
DI 10.1038/nutd.2015.23
PG 7
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA DC0HY
UT WOS:000368899000002
PM 26192450
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Bao, W
   Rong, Y
   Rong, S
   Liu, LG
AF Bao, Wei
   Rong, Ying
   Rong, Shuang
   Liu, Liegang
TI Dietary iron intake, body iron stores, and the risk of type 2 diabetes:
   a systematic review and meta-analysis
SO BMC MEDICINE
LA English
DT Review
ID GENE PROMOTER POLYMORPHISMS; BETA-CELL FUNCTION; SERUM FERRITIN;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; OXIDATIVE STRESS; TREND
   ESTIMATION; ASSOCIATION; GLUCOSE; MEN
AB Background: Excess iron has been shown to induce diabetes in animal models. However, the results from human epidemiologic studies linking body iron stores and iron intake to the risk of type 2 diabetes mellitus (T2DM) are conflicting. In this study, we aimed to systematically evaluate the available evidence for associations between iron intake, body iron stores, and the risk of T2DM.
   Methods: A systematic search of the PubMed/MEDLINE and EMBASE databases to the end of 22 April 2012 was performed, and reference lists of retrieved articles were screened. Two reviewers independently evaluated the eligibility of inclusion and extracted the data. Pooled relative risks (RRs) and 95% confidence intervals (CIs) were calculated using random-effects models.
   Results: We reviewed 449 potentially relevant articles, and 11 prospective studies were included in the analysis. A meta-analysis of five studies gave a pooled RR for T2DM of 1.33 (95% CI 1.19 to 1.48; P<0.001) in individuals with the highest level of heme iron intake, compared with those with the lowest level. The pooled RR for T2DM for a daily increment of 1 mg of heme iron intake was 1.16 (1.09 to 1.23, P<0.001). Body iron stores, as measured by ferritin, soluble transferrin receptor (sTfR) and the sTfR: ferritin ratio, were significantly associated with the risk of T2DM. The pooled RRs for T2DM in individuals with the highest versus the lowest intake of ferritin levels was 1.70 (1.27-2.27, P<0.001) before adjustment for inflammatory markers and 1.63 (1.03-2.56, P = 0.036) after adjustment. We did not find any significant association of dietary intakes of total iron, non-heme, or supplemental iron intake with T2DM risk.
   Conclusion: Higher heme iron intake and increased body iron stores were significantly associated with a greater risk of T2DM. Dietary total iron, non-heme iron, or supplemental iron intakes were not significantly associated with T2DM risk.
C1 [Bao, Wei; Rong, Ying; Rong, Shuang; Liu, Liegang] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Dept Nutr & Food Hyg,Hubei Key Lab Food Nutr & Sa, Wuhan 430030, Peoples R China.
   [Bao, Wei; Rong, Ying; Rong, Shuang; Liu, Liegang] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Minist Educ,Key Lab Environm & Hlth, Wuhan 430030, Peoples R China.
C3 Huazhong University of Science & Technology; Ministry of Education -
   China; Huazhong University of Science & Technology
RP Liu, LG (corresponding author), Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Dept Nutr & Food Hyg,Hubei Key Lab Food Nutr & Sa, 13 Hangkong Rd, Wuhan 430030, Peoples R China.
EM lgliu@mails.tjmu.edu.cn
RI Bao, Wei/AAG-2431-2019
OI Bao, Wei/0000-0002-7301-5786
FU National Natural Science Foundation of China [NSFC-30872116]
FX We thank Dr Nita Forouhi from Medical Research Council Epidemiology Unit
   in Cambridge, UK for providing data of an ad hoc analysis in the
   EPIC-Norfolk study [11]. This study was partly supported by National
   Natural Science Foundation of China (NSFC-30872116). The funders had no
   role in the study design, data collection and analysis, decision to
   publish, or preparation of the manuscript.
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NR 53
TC 200
Z9 214
U1 0
U2 59
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1741-7015
J9 BMC MED
JI BMC Med.
PD OCT 10
PY 2012
VL 10
AR 119
DI 10.1186/1741-7015-10-119
PG 13
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 055CS
UT WOS:000312393400001
PM 23046549
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Koncsos, P
   Seres, I
   Harangi, M
   Illyés, I
   Józsa, L
   Gönczi, F
   Bajnok, L
   Paragh, G
AF Koncsos, Peter
   Seres, Ildiko
   Harangi, Mariann
   Illyes, Istvan
   Jozsa, Lajos
   Goenczi, Ferenc
   Bajnok, Laszlo
   Paragh, Gyoergy
TI Human Paraoxonase-1 Activity in Childhood Obesity and Its Relation to
   Leptin and Adiponectin Levels
SO PEDIATRIC RESEARCH
LA English
DT Article
ID LOW-DENSITY-LIPOPROTEIN; BODY-MASS INDEX; METABOLIC SYNDROME;
   CARDIOVASCULAR-DISEASE; SERUM PARAOXONASE-1; INSULIN-RESISTANCE;
   OXIDATIVE STRESS; PLASMA LEPTIN; PON1 ACTIVITY; CHILDREN
AB Childhood obesity is a predisposing factor for adult cardiovascular diseases. Human serum paraoxonase (PON1) may protect against atherosclerosis by hydrolyzing lipid peroxides in oxidized LDL. Alterations and potential correlations of PON1 activities, leptin and adiponectin levels in childhood obesity were studied. We measured PON1 paraoxonase and arylesterase activities, anthropometric parameters, leptin and adiponectin levels in 59 white, obese (obese group-OB: BMI corrected for age: 95.1 +/- 3.5 percentile, age: 11.9 +/- 1.6 y) and 51 normal-weight children (control group-C: BMI corrected for age: 64.1 +/- 8.4 percentile, age: 12.0 +/- 3.9 y). Obese children had significantly lower PON1 paraoxonase (013: 84.80 (64.33/144.74) U/L versus. C: 99.42 (83.33/152.05) U/L; p < 0.05) and arylesterase activities (OB: 94.40 (82.20/108.70) U/L versus. C: 115.20 (93.70/126.00) U/L; p < 0.01), higher leptin (OB: 37.05 (24.33/53.87) ng/mL versus. C: 4.62 (2.52/17.6) ng/mL; p < 0.0001) and lower adiponectin levels (OB: 7.56 (5.69/12.06) mu g/mL versus. C: 11.51 (8.84/14.49) mu g/mL; p < 0.001) compared with the normal-weight group. PON1 arylesterase activity showed inverse univariate correlation with leptin (r = -0.29; p < 0.05) and positive correlation with adiponectin levels (r = 0.39; p < 0.01). In multiple regression analysis adiponectin was strongly associated with PON1 arylesterase activity in obese children (beta = 0.45, p < 0.02). Our results emphasize the importance of the investigated metabolic alterations which may have further effects on cardiovascular morbidity and mortality in later adulthood. Altered levels of leptin, adiponectin and PON1 activities may be useful markers beside the general risk factors in childhood obesity. (Pediatr Res 67: 309-313, 2010)
C1 [Koncsos, Peter; Seres, Ildiko; Harangi, Mariann; Paragh, Gyoergy] Univ Debrecen, Dept Med 1, H-4032 Debrecen, Hungary.
   [Illyes, Istvan] Univ Debrecen, Dept Family Med, H-4032 Debrecen, Hungary.
   [Goenczi, Ferenc] Kenezy Gyula Hosp, Dept Paediat, H-4043 Debrecen, Hungary.
   [Bajnok, Laszlo] Univ Pecs, Dept Med 1, H-7624 Pecs, Hungary.
C3 University of Debrecen; University of Debrecen; University of Pecs
RP Paragh, G (corresponding author), Univ Debrecen, Med & Hlth Sci Ctr, Dept Med 1, Nagyerdei Kri 98, H-4012 Debrecen, Hungary.
EM paragh@internal.med.unideb.hu
RI Harangi, Mariann/ACY-2278-2022
OI Harangi, Mariann/0000-0001-9761-9595
FU Hungarian Scientific Research Fund [OTKA K63025]; ETT (Medical Research
   Council) [243/2006]; Hungarian National Office for Research and
   Technology, Hungary [OMFB-1613/2006]
FX Financial Support: This work was supported by a grant from the Hungarian
   Scientific Research Fund (OTKA K63025), ETT (Medical Research Council)
   (243/2006) and Hungarian National Office for Research and Technology
   (OMFB-1613/2006), Hungary.
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NR 37
TC 41
Z9 44
U1 0
U2 7
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 0031-3998
EI 1530-0447
J9 PEDIATR RES
JI Pediatr. Res.
PD MAR
PY 2010
VL 67
IS 3
BP 309
EP 313
DI 10.1203/PDR.0b013e3181c9fb66
PG 5
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA 560BD
UT WOS:000274875900014
PM 19915520
OA Bronze
DA 2025-06-11
ER

PT J
AU Konstantinidou, V
   Khymenets, O
   Covas, MI
   de la Torre, R
   Muñoz-Aguayo, D
   Anglada, R
   Farré, M
   Fito, M
AF Konstantinidou, Valentini
   Khymenets, Olha
   Covas, Maria-Isabel
   de la Torre, Rafael
   Munoz-Aguayo, Daniel
   Anglada, Roger
   Farre, Magi
   Fito, Montserrat
TI Time Course of Changes in the Expression of Insulin Sensitivity-Related
   Genes after an Acute Load of Virgin Olive Oil
SO OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY
LA English
DT Article
ID ACTIVATED-RECEPTOR-GAMMA; ALPHA-CONVERTING-ENZYME;
   CORONARY-HEART-DISEASE; OXIDATIVE STRESS; GLUCOSE-METABOLISM;
   FATTY-ACID; PHENOLIC-COMPOUNDS; LIPOIC ACID; PPAR-GAMMA; FED RATS
AB Our aim was to examine whether an acute fat load could induce changes in the expression of insulin sensitivity-related genes in human peripheral blood mononuclear cells. Selection of candidate genes was based on previous studies with sustained virgin olive oil (VOO) consumption and biological plausibility in relation to insulin sensitivity. Eleven healthy volunteers ingested raw VOO (50 mL). Blood samples were collected at 0, 1 and 6 h. Plasma glucose, insulin and hydroxytyrosol increased at 1 h and decreased at 6 h. Lipid oxidative damage increased at 6 h (p < 0.05). Gene expression changes were characterized based on quantification of the samples relative to a reference sample [i. e., relative quantification (RQ) method]. A 1 h downregulation was observed in O-linked-N-acetylglucosamine transferase (OGT, RQ: 0.62 +/- 0.32) and arachidonate-5-lipoxygenase-activating protein (ALOX5AP, RQ: 0.64 +/- 0.31) genes (p < 0.005). OGT was upregulated at 6 h (RQ: 1.88 +/- 0.28, p < 0.05). CD36 (thrombospondin receptor) was upregulated at 1 h (RQ: 1.6 +/- 0.8, p< 0.05) returning to the basal values at 6 h. Lipoic acid synthetase (LIAS), peroxisome proliferator-activated receptor binding protein (PPARBP), a disintegrin and metallopeptidase domain 17 (ADAM17), and adrenergic beta-2-receptor (ADRB2) genes were upregulated at 6 h (range for the mean RQ: 1.33-1.56) following an increasing linear trend (p< 0.05) from baseline to 6 h. ALOX5AP and OGT genes inversely correlated with insulin and glucose levels at 1 h. ADAM17 and ADRB2 inversely correlated with oxLDL at 6 h (p< 0.05). Taken together, these observations may inform the future clinical nutrigenomics study designs and indicate that a single dose of VOO can elicit quantifiable and rapid changes in gene expression in targets that are mechanistically relevant for insulin sensitivity and the metabolic syndrome.
C1 [Konstantinidou, Valentini; Covas, Maria-Isabel; Munoz-Aguayo, Daniel; Fito, Montserrat] Hosp Mar, Inst Municipal Invest Med, Cardiovasc Risk & Nutr Res Grp, CIBER Fisiopatol Obesidad & Nutr, Barcelona 08003, Spain.
   [Khymenets, Olha; de la Torre, Rafael; Farre, Magi] Hosp Mar, Inst Municipal Invest Med, Human Pharmacol & Clin Neurosci Res Grp, Barcelona 08003, Spain.
   [Farre, Magi] Univ Autonoma Barcelona, E-08193 Barcelona, Spain.
   [de la Torre, Rafael; Anglada, Roger] Pompeu Fabra Univ, Dept Ciencies Expt & Salut, Barcelona, Spain.
C3 Hospital del Mar Research Institute; Hospital del Mar; CIBER - Centro de
   Investigacion Biomedica en Red; CIBEROBN; Hospital del Mar Research
   Institute; Hospital del Mar; Autonomous University of Barcelona; Pompeu
   Fabra University
RP Covas, MI (corresponding author), Hosp Mar, Inst Municipal Invest Med, Cardiovasc Risk & Nutr Res Grp, CIBER Fisiopatol Obesidad & Nutr, PRBB,Carrer Dr Aiguader 88, Barcelona 08003, Spain.
EM mcovas@imim.es
RI de la Torre, Rafael/D-3561-2018; Khymenets, Olha/I-9752-2014; Fito
   Colomer, Montse/C-1822-2012
OI de la Torre, Rafael/0000-0002-6765-1866; Khymenets,
   Olha/0000-0002-8668-580X; Fito Colomer, Montse/0000-0002-1817-483X
FU CICYT [SAF 2004-08173-CO3-00]; SNS [CP06/00100]; Instituto de Salud
   Carlos III; Greek State Scholarship Foundation; Generalitat of Catalunya
   [2005 SGR 00577]
FX The CIBEROBN is an initiative of the Instituto de Salud Carlos III,
   Madrid, Spain. This work has been supported by CICYT (SAF
   2004-08173-CO3-00), by SNS contract (CP06/00100) Instituto de Salud
   Carlos III, by the Greek State Scholarship Foundation (I. KY. Athens,
   Greece), and partially supported by The Generalitat of Catalunya (2005
   SGR 00577).
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NR 53
TC 41
Z9 42
U1 0
U2 13
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1536-2310
EI 1557-8100
J9 OMICS
JI OMICS
PD OCT
PY 2009
VL 13
IS 5
BP 431
EP 438
DI 10.1089/omi.2008.0085
PG 8
WC Biotechnology & Applied Microbiology; Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Genetics & Heredity
GA 500TO
UT WOS:000270328100007
PM 19422291
DA 2025-06-11
ER

PT J
AU Dizdaroglu, M
   Kirkali, G
   Jaruga, P
AF Dizdaroglu, Miral
   Kirkali, Gueldal
   Jaruga, Pawel
TI Formamidopyrimidines in DNA: Mechanisms of formation, repair, and
   biological effects
SO FREE RADICAL BIOLOGY AND MEDICINE
LA English
DT Review
DE DNA repair; Formamidopyrimidines; Mutagenesis; NEIL1; OH-adduct
   radicals; Free radicals
ID BASE-EXCISION-REPAIR; OXIDATIVELY DAMAGED DNA; COLI FPG PROTEIN;
   CENTER-DOT-DG; RADIATION-INDUCED DEGRADATION; HOGG1 SER326CYS
   POLYMORPHISM; OPEN RING 7-METHYLGUANINE; OH RADICAL REACTION;
   ESCHERICHIA-COLI; IONIZING-RADIATION
AB Oxidatively induced damage to DNA results in a plethora of lesions comprising modified bases and sugars, DNA-protein cross-links, tandem lesions, strand breaks, and clustered lesions. Formamidopyrimidines, 4,6-diamino-5-formamidopyrimidine (FapyAde) and 2,6-diamino-4-hydroxy-5-formamidopyrimidine (FapyGua), are among the major lesions generated in DNA by hydroxyl radical attack, UV radiation, or photosensitization under numerous in vitro and in vivo conditions. They are formed by one-electron reduction of C8-OH-adduct radicals of purines and thus have a common precursor with 8-hydroxypurines generated upon one-electron oxidation. Methodologies using mass spectrometry exist to accurately measure FapyAde and FapyGua in vitro and in vivo. Formamidopyrimidines are repaired by base excision repair. Numerous prokaryotic and eukaryotic DNA glycosylases are highly specific for removal of these lesions from DNA in the first step of this repair pathway, indicating their biological importance. FapyAde and FapyGua are bypassed by DNA polymerases with the insertion of the wrong intact base opposite them, leading to mutagenesis. In mammalian cells, the mutagenicity of FapyGua exceeds that of 8-hydroxyguanine, which is thought to be the most mutagenic of the oxidatively induced lesions in DNA. The background and formation levels of the former in vitro and in vivo equal or exceed those of the latter under various conditions. FapyAde and FapyGua exist in living cells at significant background levels and are abundantly generated upon exposure to oxidative stress. Mice lacking the genes that encode specific DNA glycosylases accumulate these lesions in different organs and, in some cases, exhibit a series of pathological conditions including metabolic syndrome and cancer. Animals exposed to environmental toxins accumulate formamidopyrimidines in their organs. Here, we extensively review the mechanisms of formation, measurement, repair, and biological effects of formamidopyrimidines that have been investigated in the past 50 years. Our goal is to emphasize the importance of these neglected lesions in many biological and disease processes. Published by Elsevier Inc.
C1 [Dizdaroglu, Miral; Jaruga, Pawel] NIST, Chem Sci & Technol Lab, Gaithersburg, MD 20899 USA.
   [Kirkali, Gueldal] Dokuz Eylul Univ, Fac Med, Dept Biochem, Izmir, Turkey.
C3 National Institute of Standards & Technology (NIST) - USA; Dokuz Eylul
   University
RP Dizdaroglu, M (corresponding author), NIST, Chem Sci & Technol Lab, Bldg 227-A243, Gaithersburg, MD 20899 USA.
EM miral@nist.gov
RI Jaruga, Pawel/M-4378-2015
OI Jaruga, Pawel/0000-0001-9192-6084
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NR 189
TC 109
Z9 118
U1 1
U2 22
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0891-5849
EI 1873-4596
J9 FREE RADICAL BIO MED
JI Free Radic. Biol. Med.
PD DEC 15
PY 2008
VL 45
IS 12
BP 1610
EP 1621
DI 10.1016/j.freeradbiomed.2008.07.004
PG 12
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 384CL
UT WOS:000261721800002
PM 18692130
DA 2025-06-11
ER

PT J
AU Schindler, TH
   Cardenas, J
   Prior, JO
   Facta, AD
   Kreissl, MC
   Zhang, ML
   Sayre, J
   Dahlbom, M
   Licinio, J
   Schelbert, HR
AF Schindler, TH
   Cardenas, J
   Prior, JO
   Facta, AD
   Kreissl, MC
   Zhang, ML
   Sayre, J
   Dahlbom, M
   Licinio, J
   Schelbert, HR
TI Relationship between increasing body weight, insulin resistance,
   inflammation, adipocytokine leptin, and coronary circulatory function
SO JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
LA English
DT Article
ID MYOCARDIAL BLOOD-FLOW; ENDOTHELIAL NITRIC-OXIDE; OXIDATIVE STRESS;
   RISK-FACTORS; CLINICAL-IMPLICATIONS; METABOLIC SYNDROME;
   DIABETES-MELLITUS; MASS INDEX; VITAMIN-C; DYSFUNCTION
AB OBJECTIVES We sought to evaluate effects of obesity, insulin resistance, and inflammation on coronary circulatory function and its relationship to leptin plasma levels.
   BACKGROUND It is not known whether obesity, commonly paralleled by insulin resistance, inflammation, and leptin, is independently associated with coronary circulatory dysfunction.
   METHODS Myocardial blood flow (MBF) responses to cold pressor test (CPT) and pharmacologic vasodilation was measured with positron emission tomography and N-13-ammonia. Study participants were divided into three groups based on their body mass index (BMI, kg/m(2)) : control, 20 <= BMI < 25 (n = 19); overweight, 25 <= BMI < 30 (n = 21); and obese, BMI > 30 (n = 32).
   RESULTS Body mass index was significantly correlated to the Homeostasis Model Assessment Index of insulin resistance and C-reactive protein levels (r = 0.60 and r = 0.47, p < 0.0001). Compared with control subjects, endothelium-related change in MBF (AMBF) to CPT progressively declined in overweight and obese groups (0.32 +/- 0.09 vs. 0.21 +/- 0.19 and 0.07 +/- 0.16 ml/g/min; p < 0.03 and p < 0.0001). The dipyridamole-induced total vasodilator capacity was significantly lower in obese than in control subjects (1.77 +/- 0.51 vs. 2.04 +/- 0.37 ml/g/min, p < 0.02). On multivariate analysis, BMI (p < 0.012) and age (p < 0.035) were significant independent predictors of AMBF. Finally, only in the obese group leptin plasma levels significantly correlated with AMBF (r = 0.37, p < 0.036).
   CONCLUSIONS Increased body weight is independently associated with abnormal coronary circulatory function that progresses from an impairment in endothelium-related coronary vasomotion in overweight individuals to an impairment of the total vasodilator capacity in obese individuals. The findings that elevated leptin plasma levels in patients that are obese might exert beneficial effects on the coronary endothelium to counterbalance the adverse effects of increases in body weight on coronary circulatory function should be tested.
C1 Univ Calif Los Angeles, David Geffen Sch Med, Dept Mol & Med Pharmacol, Los Angeles, CA 90095 USA.
   Univ Calif Los Angeles, David Geffen Sch Med, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90095 USA.
   Univ Calif Los Angeles, David Geffen Sch Med, Dept Med Endocrinol, Los Angeles, CA 90095 USA.
C3 University of California System; University of California Los Angeles;
   University of California Los Angeles Medical Center; David Geffen School
   of Medicine at UCLA; University of California System; University of
   California Los Angeles; University of California Los Angeles Medical
   Center; David Geffen School of Medicine at UCLA; University of
   California System; University of California Los Angeles; University of
   California Los Angeles Medical Center; David Geffen School of Medicine
   at UCLA
RP Univ Calif Los Angeles, David Geffen Sch Med, Dept Mol & Med Pharmacol, 10833 Conte Ave,23-120 CHS,Box 173517, Los Angeles, CA 90095 USA.
EM hschelbert@mednet.ucla.edu
RI Licinio, Julio/L-4244-2013; Kreissl, Michael Christoph/GRR-9938-2022;
   Prior, John/I-5364-2017
OI Licinio, Julio/0000-0001-6905-5884; Kreissl, Michael
   Christoph/0000-0001-5905-6015; Schindler, Thomas
   Hellmut/0000-0002-2141-7716; Prior, John/0000-0003-1429-1374
FU NCRR NIH HHS [RR016996] Funding Source: Medline; NHLBI NIH HHS [HL
   33177] Funding Source: Medline; NIDDK NIH HHS [DK058851, DK063240]
   Funding Source: Medline
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NR 30
TC 192
Z9 205
U1 0
U2 9
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0735-1097
EI 1558-3597
J9 J AM COLL CARDIOL
JI J. Am. Coll. Cardiol.
PD MAR 21
PY 2006
VL 47
IS 6
BP 1188
EP 1195
DI 10.1016/j.jacc.2005.10.062
PG 8
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 025TU
UT WOS:000236290600016
PM 16545651
DA 2025-06-11
ER

PT J
AU Darabi, M
   Lhomme, M
   Ponnaiah, M
   Pucic-Bakovic, M
   Guillas, I
   Frisdal, E
   Bittar, R
   Croyal, M
   Matheron-Duriez, L
   Poupel, L
   Bonnefont-Rousselot, D
   Frere, C
   Varret, M
   Krempf, M
   Cariou, B
   Lauc, G
   Guerin, M
   Carrie, A
   Bruckert, E
   Giral, P
   Le Goff, W
   Kontush, A
AF Darabi, Maryam
   Lhomme, Marie
   Ponnaiah, Maharajah
   Pucic-Bakovic, Maja
   Guillas, Isabelle
   Frisdal, Eric
   Bittar, Randa
   Croyal, Mikael
   Matheron-Duriez, Lucrece
   Poupel, Lucie
   Bonnefont-Rousselot, Dominique
   Frere, Corinne
   Varret, Mathilde
   Krempf, Michel
   Cariou, Bertrand
   Lauc, Gordan
   Guerin, Maryse
   Carrie, Alain
   Bruckert, Eric
   Giral, Philippe
   Le Goff, Wilfried
   Kontush, Anatol
TI Integrated omics approach for the identification of HDL
   structure-function relationships in PCSK9-related familial
   hypercholesterolemia
SO JOURNAL OF CLINICAL LIPIDOLOGY
LA English
DT Article
DE Proprotein convertase subtilisin kexin type 9; High-density
   lipoproteins; Gain-of-function mutation; Low-density lipoprotein
   receptor; Familial hypercholesterolemia; Computational biology
ID HIGH-DENSITY-LIPOPROTEIN; REVERSE CHOLESTEROL TRANSPORT; ELEVATED
   OXIDATIVE STRESS; EFFLUX CAPACITY; PCSK9 GENE; DEFECTIVE FUNCTIONALITY;
   COMPLEMENT ACTIVATION; METABOLIC SYNDROME; HUMAN PLASMA; PARTICLES
AB Background: The role of proprotein convertase subtilisin/kexin type 9 (PCSK9) in dyslipidemia may go beyond its immediate effects on low-density lipoprotein receptor (LDL-R) activity.Objective: This study aimed to assess PCSK9-derived alterations of high-density lipoprotein (HDL) physiology, which bear a potential to contribute to cardiovascular risk profile.Methods: HDL was isolated from 33 patients with familial autosomal dominant hypercholes-terolemia (FH), including those carrying PCSK9 gain-of-function (GOF) genetic variants (FH-PCSK9, n = 11), together with two groups of dyslipidemic patients employed as controls and carrying ge-netic variants in the LDL-R not treated (ntFH-LDLR, n = 11) and treated (tFH-LDLR, n = 11) with statins, and 11 normolipidemic controls. Biological evaluations paralleled by proteomic, lipidomic and glycomic analyses were applied to characterize functional and compositional properties of HDL. Results: Multiple deficiencies in the HDL function were identified in the FH-PCSK9 group rela-tive to dyslipidemic FH-LDLR patients and normolipidemic controls, which involved reduced antiox-idative, antiapoptotic, anti-thrombotic and anti-inflammatory activities. By contrast, cellular choles-terol efflux capacity of HDL was unchanged. In addition, multiple alterations of the proteomic, lipidomic and glycomic composition of HDL were found in the FH-PCSK9 group. Remarkably, HDLs from FH-PCSK9 patients were systematically enriched in several lysophospholipids as well as in A2G2S2 (GP13) glycan and apolipoprotein A-IV. Based on network analysis of functional and compositional data, a novel mosaic structure-function model of HDL biology involving FH was developed. Conclusion: Several metrics of anti-atherogenic HDL functionality are altered in FH-PCSK9 patients paralleled by distinct compositional alterations. These data provide a first-ever overview of the impact of GOF PCSK9 genetic variants on structure-function relationships in HDL.(c) 2023 National Lipid Association. Published by Elsevier Inc. All rights reserved.
C1 [Darabi, Maryam; Guillas, Isabelle; Frisdal, Eric; Poupel, Lucie; Guerin, Maryse; Carrie, Alain; Le Goff, Wilfried; Kontush, Anatol] Sorbonne Univ, Pitie Salpetriere Hosp, INSERM, Inst Cardiometab & Nutr ICAN,UMR S116, F-75013 Paris, France.
   [Darabi, Maryam] Paris Saclay Univ, LPS BioSci, F-91400 Orsay, France.
   [Lhomme, Marie] Fdn Innovat Cardiometab & Nutr, ANR IAHU 05 10, Lipid Core, IHU ICAN,ICAN Analyt, Paris, France.
   [Ponnaiah, Maharajah] Fdn Innovat Cardiometab & Nutr, ANR 10 IAHU 05, Inst Cardiometab & Nutr, ICAN IO,IHU ICAN, Paris, France.
   [Bittar, Randa; Bonnefont-Rousselot, Dominique] Pitie Salpetriere Charles Foix Univ Hosp, AP HP, Dept Metab Biochem, Paris, France.
   [Bonnefont-Rousselot, Dominique] Univ Paris, CNRS, INSERM, UTCBS, F-75006 Paris, France.
   [Croyal, Mikael; Cariou, Bertrand] Univ Nantes, CHU Nantes, CNRS INSERM, Inst Thorax, F-44000 Nantes, France.
   [Croyal, Mikael] Univ Nantes, CHU Nantes, Inserm UMS 016, CNRS,SFR Sante,CNRS UMS 3556, F-44000 Nantes, France.
   [Croyal, Mikael; Krempf, Michel] CRNH Ouest Mass Spectrometry Core Facil, Inst Thorax, UMR 1087, F-44000 Nantes, France.
   [Varret, Mathilde] Paris Univ, Univ Paris, X Bichat Hosp, LVTS INSERM U1148, F-75018 Paris, France.
   [Varret, Mathilde] Sorbonne Paris Nord Univ, Natl Inst Hlth & Med Res INSERM, LVTS, F-75018 Paris, France.
   [Pucic-Bakovic, Maja; Lauc, Gordan] Genos Glycoscience Res Lab, Borongajska cesta 83H, HR-10000 Zagreb, Croatia.
   [Matheron-Duriez, Lucrece] Sorbonne Univ, Inst Biol Paris Seine FR 3631, Platform MS3U, Paris, France.
   [Frere, Corinne] Sorbonne Univ, Pitie Salpetriere Hosp, Assistance Publ Hop Paris, Dept Haematol, Paris, France.
   [Krempf, Michel] Clin Breteche, Grp ELSAN, Nantes, France.
   [Bruckert, Eric; Giral, Philippe] Hop La Pitie Salpetriere, Inst E3M & IHU Cardiometab ICAN, Endocrinol Metab & Prevent Cardiovasc, Paris, France.
   [Kontush, Anatol] Sorbonne Univ, INSERM, UMR S1166, ICAN, 91Blvd Hop, F-75013 Paris, France.
C3 Assistance Publique Hopitaux Paris (APHP); Hopital Universitaire
   Pitie-Salpetriere - APHP; Sorbonne Universite; Institut National de la
   Sante et de la Recherche Medicale (Inserm); Universite Paris Saclay;
   Institut National de la Sante et de la Recherche Medicale (Inserm);
   Institut National de la Sante et de la Recherche Medicale (Inserm);
   Sorbonne Universite; Assistance Publique Hopitaux Paris (APHP); Hopital
   Universitaire Pitie-Salpetriere - APHP; Sorbonne Universite; Hopital
   Universitaire Charles-Foix - APHP; Universite Paris Cite; Centre
   National de la Recherche Scientifique (CNRS); Institut National de la
   Sante et de la Recherche Medicale (Inserm); Institut National de la
   Sante et de la Recherche Medicale (Inserm); Nantes Universite; CHU de
   Nantes; Nantes Universite; CHU de Nantes; Centre National de la
   Recherche Scientifique (CNRS); CNRS - National Institute for Biology
   (INSB); Institut National de la Sante et de la Recherche Medicale
   (Inserm); Institut National de la Sante et de la Recherche Medicale
   (Inserm); Nantes Universite; CHU de Nantes; Institut National de la
   Sante et de la Recherche Medicale (Inserm); Assistance Publique Hopitaux
   Paris (APHP); Universite Paris Cite; Hopital Universitaire Bichat-Claude
   Bernard - APHP; Universite Paris Cite; Institut National de la Sante et
   de la Recherche Medicale (Inserm); Centre National de la Recherche
   Scientifique (CNRS); CNRS - National Institute for Biology (INSB);
   Sorbonne Universite; Assistance Publique Hopitaux Paris (APHP); Hopital
   Universitaire Pitie-Salpetriere - APHP; Sorbonne Universite; Universite
   Paris Cite; Hopital Universitaire Saint-Louis - APHP; Sorbonne
   Universite; Assistance Publique Hopitaux Paris (APHP); Hopital
   Universitaire Pitie-Salpetriere - APHP; Institut National de la Sante et
   de la Recherche Medicale (Inserm); Sorbonne Universite
RP Kontush, A (corresponding author), Sorbonne Univ, INSERM, UMR S1166, ICAN, 91Blvd Hop, F-75013 Paris, France.
EM anatol.kontush@sorbonne-universite.fr
RI CARIOU, Bertrand/D-6398-2015; Kontush, Anatol/J-2198-2016; Darabi,
   Maryam/C-7527-2011; Guerin, Maryse/N-5794-2017; Pucic-Bakovic,
   Maja/JAC-0077-2023; Lauc, Gordan/K-5864-2012; Le Goff,
   Wilfried/N-6326-2017; VARRET, Mathilde/C-2279-2016
OI Poupel, Lucie/0000-0001-7015-8450; Darabi, Maryam/0000-0003-2230-9044;
   Croyal, Mikael/0000-0002-5449-5817; Guillas,
   Isabelle/0000-0002-6073-0529; GUERIN, Maryse/0000-0003-0150-1360;
   Carrie, Alain/0000-0003-4726-1171; Le Goff,
   Wilfried/0000-0002-7611-9644; Pucic-Bakovic, Maja/0000-0003-0866-623X;
   Kontush, Anatol/0000-0002-9008-7335; VARRET,
   Mathilde/0000-0001-9261-1551
FU Pfizer ASPIRE Research Grant in Cardiovascular Research; Croatian
   Science Foundation [UIP-2019-04-5692]
FX This study was primarily supported by a Pfizer ASPIRE Research Grant in
   Cardiovascular Research. Continuous support provided by the National
   Institute for Health and Medical Research (INSERM) and Sorbonne
   University (Paris, France) is gratefully acknowledged. We are grateful
   to the Croatian Science Foundation for providing support to the project
   "GLYCARD: Glycosylation in Cardiovascular Dis-eases" (UIP-2019-04-5692)
   .
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NR 87
TC 5
Z9 5
U1 0
U2 6
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1933-2874
EI 1876-4789
J9 J CLIN LIPIDOL
JI J. Clin. Lipidol.
PD SEP-OCT
PY 2023
VL 17
IS 5
BP 643
EP 658
DI 10.1016/j.jacl.2023.07.003
EA NOV 2023
PG 16
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA DK2E3
UT WOS:001131858100001
PM 37550151
OA Bronze, Green Submitted
DA 2025-06-11
ER

PT J
AU Da Costa-Santos, N
   Costa, GMS
   Dos-Santos, A
   Nascimento-Carvalho, B
   Ribeiro, TF
   Freitas, SCF
   Caperuto, E
   Irigoyen, MC
   De Angelis, K
   Scapini, KB
   Sanches, IC
AF Da Costa-Santos, Nicolas
   Costa, Gabrielly Minguta Santos
   Dos-Santos, Adriano
   Nascimento-Carvalho, Bruno
   Ribeiro, Thayna Fabiana
   Freitas, Sarah Cristina Ferreira
   Caperuto, Erico
   Irigoyen, Maria -Claudia
   De Angelis, Katia
   Scapini, Katia Bilhar
   Sanches, Iris Callado
TI Combined Exercise Training Promotes More Benefits on Cardiovascular
   Autonomic Modulation in Ovariectomized Rats Than Isolated Aerobic or
   Resistance Training
SO DIABETES METABOLIC SYNDROME AND OBESITY
LA English
DT Article
DE combined exercise training; resistance exercise training; aerobic
   exercise training; ovarian hormone deprivation; cardiovascular autonomic
   modulation; baroreflex sensitivity
ID HEART-RATE-VARIABILITY; OXIDATIVE STRESS; INSULIN-RESISTANCE;
   EXPERIMENTAL-MODEL; METABOLIC SYNDROME; DYSFUNCTION; MENOPAUSE;
   HYPERTENSION; IMPACT
AB Introduction: Cardiovascular risk increase after ovarian deprivation has been extensively demonstrated by our research group through cardiovascular autonomic analysis. Interventions involving different types of exercises, such as resistance exercises or combined exercises (aerobic and resistance) have been widely recommended to prevent or minimize neuromuscular decline in postmenopausal women, which is aggravated by a sedentary lifestyle. Experimentally, the cardiovascular effects of resistance or combined training, as well as comparison between aerobic, resistance, and combined training, in ovariectomized animals are scarce. Purpose: In this study, we hypothesized that the combination of aerobic and resistance training may be more effective in preventing muscle mass loss, as well as improving cardiovascular autonomic modulation and baroreflex sensitivity, than aerobic or resistance training individually in ovariectomized rats. Animals and Methods: Female rats were divided into 5 groups: sedentary (C); ovariectomized (Ovx); trained ovariectomized submitted to aerobic training (OvxAT); resistance training (OvxRT); combined training (OvxCT). Exercise training lasted 8 weeks, with the combined group alternating between aerobic training and resistance training every other day. At the end of the study, glycemia and insulin tolerance were evaluated. Arterial pressure (AP) was directly recorded. Baroreflex sensitivity was assessed by heart rate response to changes in arterial pressure. Cardiovascular autonomic modulation was evaluated by spectral analysis. Results: Combined training was the only training regime that increased baroreflex sensitivity for tachycardic response and reduced all systolic blood pressure variability parameters. Furthermore, all animals submitted to exercise training on a treadmill (OvxAT and OvxCT) presented lower systolic, diastolic, and mean pressure, as well as improvements in the autonomic modulation for the heart. Conclusion: Combined training showed to be more effective than isolated aerobic and resistance training, mixing the isolated benefits of each modality. It was the only modality able to increase baroreflex sensitivity to tachycardic responses, reduce arterial pressure and all parameters of vascular sympathetic modulation.
C1 [Da Costa-Santos, Nicolas; Ribeiro, Thayna Fabiana; Caperuto, Erico; Scapini, Katia Bilhar; Sanches, Iris Callado] Sao Judas Univ, Human Movement Lab, Sao Paulo, Brazil.
   [Costa, Gabrielly Minguta Santos; Freitas, Sarah Cristina Ferreira] Univ Nove Julho UNINOVE, Lab Translat Physiol, Sao Paulo, Brazil.
   [Nascimento-Carvalho, Bruno; Irigoyen, Maria -Claudia] Univ Sao Paulo, Heart Inst, Med Sch, Hypertens Unit, Sao Paulo, Brazil.
   [De Angelis, Katia] Fed Univ Sao Paulo UNIFESP, Dept Physiol, Physiol Exercise Lab, Sao Paulo, Brazil.
   [Sanches, Iris Callado] Sao Judas Univ, Human Movement Lab, Rua taquari 546, BR-03166000 Sao Paulo, SP, Brazil.
C3 Universidade Nove de Julho; Universidade de Sao Paulo; Universidade
   Federal de Sao Paulo (UNIFESP)
RP Sanches, IC (corresponding author), Sao Judas Univ, Human Movement Lab, Rua taquari 546, BR-03166000 Sao Paulo, SP, Brazil.
EM iris.sanches@saojudas.br
RI Freitas, Sarah/Y-1938-2018; Nascimento-Carvalho, Bruno/HLX-3548-2023;
   Caperuto, Erico/I-3605-2014; DE ANGELIS, KATIA/I-6098-2016; Sanches,
   Iris Callado/D-5079-2013; Irigoyen, maria Claudia/N-6880-2014
OI Da Costa Santos, Nicolas/0000-0002-8753-0105; Sanches, Iris
   Callado/0000-0001-6195-4340; do Nascimento Carvalho,
   Bruno/0000-0002-0283-7432; Irigoyen, maria Claudia/0000-0003-2097-3662
FU Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior--Brazil
   (CAPES); Conselho Nacional de Desenvolvimento Cientifico e Tecnologico
   (CNPQ); Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP);
   Anima Institute (AI); CAPES-PROSUP scholarship; FAPESP scholarship
   [2016/21302-3]
FX This study was financed by Coordenacao de Aperfeicoamento de Pessoal de
   Nivel Superior--Brazil (CAPES), Conselho Nacional de Desenvolvimento
   Cientifico e Tecnologico (CNPQ), Fundacao de Amparo a Pesquisa do Estado
   de Sao Paulo (FAPESP), and Anima Institute (AI). N.C.S., A.S., B.N.C.,
   and MAS were recipients of the CAPES-PROSUP scholarship. GMSC received a
   FAPESP scholarship (2016/21302-3) . I.C.S. was recipient of
   CNPq/Universal (435123/2018-1) .
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NR 51
TC 0
Z9 0
U1 3
U2 11
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-7007
J9 DIABET METAB SYND OB
JI Diabetes Metab. Syndr. Obes.
PY 2023
VL 16
BP 1903
EP 1913
DI 10.2147/DMSO.S386944
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA L3FO4
UT WOS:001022153100001
PM 37398943
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Ashkar, F
   Eftekhari, MH
   Tanideh, N
   Koohpeyma, F
   Mokhtari, M
   Irajie, C
   Iraji, A
AF Ashkar, Fatemeh
   Eftekhari, Mohammad Hassan
   Tanideh, Nader
   Koohpeyma, Farhad
   Mokhtari, Maral
   Irajie, Cambyz
   Iraji, Aida
TI Effect of hydroalcoholic extract of Berberis integerrima and
   resveratrol on ovarian morphology and biochemical parameters in
   Letrozole-induced polycystic ovary syndrome rat model: An experimental
   study
SO INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE
LA English
DT Article
DE Barberry; Resveratrol; Polycystic ovary syndrome; Ovary; Rat
ID OXIDATIVE STRESS; METABOLIC SYNDROME; INSULIN-RESISTANCE; LIPID PROFILE;
   TNF-ALPHA; BARBERRY; VULGARIS; ANTIOXIDANT; EXPRESSION; SUPPLEMENTATION
AB Background: Resveratrol and Berberis integerrima (B. integerrima) are known to be natural antioxidants and regulators of human metabolism. However, the effects of resveratrol and B. integerrima on the ovarian morphology in polycystic ovary syndrome (PCOS) are not obvious.
   Objective: This study aimed to determine the effect of the hydroalcoholic extract of B. integerrima in combination with resveratrol on some biochemical parameters and ovarian morphology in the letrozole-induced PCOS rat.
   Materials and Methods: Seventy adult female Sprague-Dawley rats aged 10-12 weeks weighing 200 +/- 20 gr were randomly divided into seven groups (n =10/each). Group I): normal; Group II): vehicle; Group III): letrozole-induced PCOS 1 mg/kg letrozole orally, rats receiving 1 cc normal saline orally; Group IV): PCOS + receiving 150 mg/kg metformin orally; Group V): PCOS + receiving 20 mg/kg resveratrol orally; Group VI): PCOS + 3 gr/kg barberry orally; and Group VII): PCOS + receiving 3 gr/kg barberry and 20 mg/kg resveratrol orally. All animals were followed -up for 63 days. The biochemical parameters and histological assessments of ovaries were performed.
   Results: Resveratrol alone and/or in combination with B. integerrima treatment in rats led to a significant decrease in low-density lipoprotein, triglyceride, malondialdehyde , and tumor necrosis factor-alpha concentrations (p = 0.02). The groups IV, V, VI, and VII showed a decrease in insulin resistance and an increase in the superoxide dismutase, total antioxidant capacity, and high-density lipoprotein (p = 0.01). No significant difference was observed between the level of serum glucose in the treatment groups. Number of cystic follicles had a significant decrease in barberry, resveratrol, and their combination groups (p < 0.001).
   Conclusion: Resveratrol, B. integerrima, and their combination as natural products with fewer side effects might be effective as an alternative medicine in treatment of PCOS.
C1 [Ashkar, Fatemeh; Eftekhari, Mohammad Hassan] Shiraz Univ Med Sci, Sch Nutr & Food Sci, Dept Clin Nutr, Shiraz, Iran.
   [Tanideh, Nader] Shiraz Univ Med Sci, Stem Cells Technol Res Ctr, Zand Blvd, Shiraz 7134845794, Iran.
   [Koohpeyma, Farhad] Shiraz Univ Med Sci, Endocrinol & Metab Res Ctr, Dept Endocrinol, Shiraz, Iran.
   [Mokhtari, Maral] Shiraz Univ Med Sci, Sch Med, Dept Pathol, Shiraz, Iran.
   [Irajie, Cambyz] Shiraz Univ Med Sci, Sch Adv Med Sci & Technol, Dept Med Biotechnol, Shiraz, Iran.
   [Iraji, Aida] Shiraz Univ Med Sci, Med & Nat Prod Chem Res Ctr, Shiraz, Iran.
C3 Shiraz University of Medical Science; Shiraz University of Medical
   Science; Shiraz University of Medical Science; Tehran University of
   Medical Sciences; Shiraz University of Medical Science; Shiraz
   University of Medical Science; Shiraz University of Medical Science
RP Tanideh, N (corresponding author), Shiraz Univ Med Sci, Stem Cells Technol Res Ctr, Zand Blvd, Shiraz 7134845794, Iran.
EM tanidehn@gmail.com
RI Mokhtari, Maral/I-2348-2015; Tanideh, Nader/M-3336-2013; Irajie,
   Cambyz/A-3729-2019; Iraji, Aida/Z-1682-2018
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NR 47
TC 19
Z9 22
U1 5
U2 9
PU SHAHID SADOUGHI UNIV MEDICAL SCIENCES
PI YAZD
PA BOUALI AVE, SAFAEYEH, YAZD, SAFAIEEH 8915887857, IRAN
SN 2476-4108
EI 2476-3772
J9 INT J REPROD BIOMED
JI Int. J. Reprod. Biomed.
PD AUG
PY 2020
VL 18
IS 8
BP 637
EP 650
DI 10.18502/ijrm.v13i8.7505
PG 14
WC Obstetrics & Gynecology
WE Emerging Sources Citation Index (ESCI)
SC Obstetrics & Gynecology
GA NG2ET
UT WOS:000563798900008
PM 32923930
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Muralimanoharan, S
   Guo, C
   Myatt, L
   Maloyan, A
AF Muralimanoharan, S.
   Guo, C.
   Myatt, L.
   Maloyan, A.
TI Sexual dimorphism in miR-210 expression and mitochondrial dysfunction in
   the placenta with maternal obesity
SO INTERNATIONAL JOURNAL OF OBESITY
LA English
DT Article
ID LONGITUDINAL CHANGES; METABOLIC SYNDROME; OXIDATIVE STRESS; PREGNANCY;
   FETAL; MICRORNAS; HYPOXIA; TROPHOBLAST; RESPIRATION; STILLBIRTH
AB BACKGROUND: Maternal obesity is a major problem in obstetrics, and the placenta is involved in obesity-related complications via its roles at the maternal-fetal interface. We have recently shown a causative role for micro(mi) RNA-210, a so called 'hypoxamir' regulated by HIF-1 alpha, in mitochondrial dysfunction in placentas from women with preeclampsia. We also reported mitochondrial dysfunction in placentas with maternal obesity. Here we hypothesized that expression of miR-210 is dysregulated in the placentas with obesity.
   METHODS: Placentas from uncomplicated pregnancies were collected at term from healthy weight or control (CTRL, pre-pregnancy body mass index (BMI) <25), overweight (OW, BMI = 25-24.9) and obese (OB, BMI > 30) women following C-section with no labor. Expression of miRNA-210 and its target genes was measured by reverse transcription-PCR and Western Blot, respectively. Mitochondrial respiration was assessed by Seahorse Analyzer in syncytiotrophoblast (ST) 72 h after cytotrophoblast isolation.
   RESULTS: Expression of miR-210 was significantly increased in placentas of OB and OW women with female but not male fetuses compared with CTRL placentas of females. However, expression of HIF-1 alpha in these placentas remained unchanged. Levels of tumor-necrosis factor-alpha (TNF alpha) were increased in OW and OB placentas of females but not males, and in silico analysis suggested that activation of miR-210 expression in these placentas might be activated by NF kappa B1 (p50) signaling. Indeed, chromatin Immunoprecipitation assay showed that NFkB1 binds to placental miR-210 promoter in a fetal sex-dependent manner. Female but not male STs treated with TNF alpha showed overexpression of miR-210, reduction of mitochondrial target genes and decreased mitochondrial respiration. Pre-treatment of these STs with small interfering RNA to NFkB1 or antagomiR-210 prevented the TNF alpha-mediated inhibition of mitochondrial respiration.
   CONCLUSIONS: Our data suggest that the inflammatory intrauterine environment associated with maternal obesity induces an NF kappa B1-mediated increase in miR-210 in a fetal sex-dependent manner, leading to inhibition of mitochondrial respiration and placental dysfunction in the placentas of female fetuses.
C1 [Muralimanoharan, S.; Guo, C.; Myatt, L.; Maloyan, A.] Univ Texas Hlth Sci Ctr San Antonio, Dept Obstet & Gynecol, Ctr Pregnancy & Newborn Res, San Antonio, TX 78229 USA.
C3 University of Texas System; University of Texas Health Science Center at
   San Antonio
RP Maloyan, A (corresponding author), Univ Texas Hlth Sci Ctr San Antonio, Dept Obstet & Gynecol, Ctr Pregnancy & Newborn Res, 7703 Floyd Curl Dr, San Antonio, TX 78229 USA.
EM maloyan@uthscsa.edu
OI Maloyan, Alina/0000-0002-7309-5026
FU Institute for Integration of Medicine and Science (IIMS) at UTHSCSA
   [HD076259A, HL075297]; CTSA grant from the Institute for Integration of
   Medicine and Science (IIMS) at UTHSCSA [UL1RR025767]
FX We are thankful to the funding sources HD076259A (LM and AM), HL075297
   (LM), and CTSA grant (UL1RR025767) from the Institute for Integration of
   Medicine and Science (IIMS) at UTHSCSA (AM).
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NR 59
TC 90
Z9 96
U1 1
U2 19
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0307-0565
EI 1476-5497
J9 INT J OBESITY
JI Int. J. Obes.
PD AUG
PY 2015
VL 39
IS 8
BP 1274
EP 1281
DI 10.1038/ijo.2015.45
PG 8
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA CR0BK
UT WOS:000360983000014
PM 25833255
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Li, Y
   Li, Y
   Meng, L
   Zheng, LS
AF Li, Ying
   Li, Yue
   Meng, Lu
   Zheng, LianShun
TI Association between Serum C-Peptide as a Risk Factor for Cardiovascular
   Disease and High-Density Lipoprotein Cholesterol Levels in Nondiabetic
   Individuals
SO PLOS ONE
LA English
DT Article
ID NITRIC-OXIDE SYNTHASE; OXIDATIVE STRESS; INSULIN-RESISTANCE; METABOLIC
   SYNDROME; NEUROPATHY; CORONARY; CHEMOTAXIS; ADULTS; HEART
AB Objective: Objective: Although serum C-peptide has increasingly received attention as a new and important risk factor for cardiovascular disease (CVD), the potential mechanisms remain unclear. This study aimed to investigate the association between serum C-peptide as a risk factor for CVD and high-density lipoprotein cholesterol (HDL-C) levels.
   Methods: The present study included 13,185 participants aged >= 20 years. Serum C-peptide and HDL-C levels were measured according to a standard protocol. Stratified analysis of covariance was used to compare serum HDL-C levels between different quartiles of serum C-peptide levels. Logistic regression analysis was used to determine the association between serum C-peptide and HDL-C levels. Cox proportional hazard regression analysis was conducted to determine the hazard ratio of serum HDL-C for CVD-related mortality.
   Results: The results of the ANCOVA analysis showed a significant linear trend between the mean serum HDL-C level and the different quartiles of serum C-peptide. Compared to the first quartile (25th percentile), the second, third, and fourth quartiles had gradual reduction in serum HDL-C levels. Logistic regression analyses showed a strong negative association between serum C-peptide levels and HDL-C levels; the p value for the linear trend was <0.001. In men, compared with the lowest quartile of the serum C-peptide level, the relative risk was 1.75, 2.79, and 3.07 for the upper three quartiles of the serum C-peptide level. The relative risk was 1.60, 2.61, and 3.67 for women. The results of the survival analysis showed that serum HDL-C levels were negatively associated with CVD-related death in both men and women.
   Conclusion: Serum C-peptide as a risk factor for CVD was significantly and negatively associated with serum HDL-C levels in individuals without diabetes. These findings suggest that serum C-peptide levels association with CVD death can be caused, at least in part, by the low serum HDL-C level.
C1 [Li, Ying; Meng, Lu] Zhejiang Univ, Sch Publ Hlth, Dept Social Med, Hangzhou, Zhejiang, Peoples R China.
   [Li, Yue; Zheng, LianShun] Zhejiang Univ, Sch Basic Med Sci, Hangzhou, Zhejiang, Peoples R China.
C3 Zhejiang University; Zhejiang University
RP Li, Y (corresponding author), Zhejiang Univ, Sch Publ Hlth, Dept Social Med, Hangzhou, Zhejiang, Peoples R China.
EM ying_li@zju.edu.cn; zhenglianshun@zju.edu.cn
FU National Science Foundation of China (NSFC) [61375049]; Zhejiang
   Provincial Natural Science Foundation of China [Y14H260013]
FX This work was supported in part by National Science Foundation of China
   (NSFC 61375049), and in part by Zhejiang Provincial Natural Science
   Foundation of China (Y14H260013). The funders had no role in study
   design, data collection and analysis, decision to publish, or
   preparation of the manuscript.
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NR 35
TC 15
Z9 18
U1 0
U2 13
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JAN 5
PY 2015
VL 10
IS 1
AR e112281
DI 10.1371/journal.pone.0112281
PG 14
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA AZ3BG
UT WOS:000348102200004
PM 25559358
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Koller, A
   Szenasi, A
   Dornyei, G
   Kovacs, N
   Lelbach, A
   Kovacs, I
AF Koller, Akos
   Szenasi, Annamaria
   Dornyei, Gabriella
   Kovacs, Nora
   Lelbach, Adam
   Kovacs, Imre
TI Coronary Microvascular and Cardiac Dysfunction Due to Homocysteine
   Pathometabolism; A Complex Therapeutic Design
SO CURRENT PHARMACEUTICAL DESIGN
LA English
DT Review
DE Methionine; homocysteine; endothelial dysfunction; oxidative stress;
   inflammation; hyperhomocysteinemia
ID CYSTATHIONINE BETA-SYNTHASE; SMOOTH-MUSCLE-CELLS; MONOCYTE
   CHEMOATTRACTANT PROTEIN-1; NECROSIS-FACTOR-ALPHA; IMPAIRED NITRIC-OXIDE;
   RAT CAROTID ARTERIES; DEEP-VEIN THROMBOSIS; ENDOTHELIAL DYSFUNCTION;
   PLASMA HOMOCYSTEINE; ANGIOTENSIN-II
AB In various metabolic diseases, both the coronary circulation and cardiac metabolism are altered. Here we summarize the effects of a condition called hyperhomocysteinemia (HHcy) - which can develop due to genetic and/or environmental causes - on the function of coronary microvessels and heart. This metabolic disease is underappreciated, yet even mild or moderate elevation of plasma concentrations of homocystein (Hcy, plasma Hcy >16 mu M), a sulfur-containing amino acid produced via methionine metabolism) leads to coronary and peripheral artery and even venous vessel diseases, eliciting vasomotor dysfunction and increased thrombosis, consequently increased morbidity and mortality. Yet the underlying mechanisms have not yet been revealed. Recent studies indicated that there are common pathomechanisms, which may affect several cellular functions. With methionin diet-induced HHcy two main pathomechanisms were revealed: the dysfunction of nitric oxide (NO) pathway resulting in reduced dilator responses of arteries and arterioles, and the simultaneously increased thromboxane A(2) (TXA(2)) activity both in vessels and platelets. These changes are likely due to an increased production of reactive oxidative species (oxidative stress) due to increased NADPH oxidase assembly, which eventually lead to inflammatory processes (indicated by increases in TNF alpha, NF kappa beta, p22phox, p67phox, and rac-1, levels) and changes in various gene expressions and morphological remodeling of vessels. Increased superoxide production and reduced availability of NO alter the regulation of mitochondrial function in the myocardium. The interactions of these pathomechanisms may explain why HHcy increases the uptake of glucose and lactate and decreases the uptake of free fatty acid by the heart. The pathological consequences of HHcy could be worsening by the simultaneous presence of other risk factors, such as hyperlipidemia, diabetes mellitus and metabolic syndrome. All in all, HHcy and associated pathometabolism lead to severe changes and dysfunctions of coronary arterial vessels and cardiac function, which may not always be apparent in clinical settings but most likely contribute to the increased prevalence of cardiovascular diseases and mortality, which however can be reduced by appropriate prevention and treatments. We believe that HHcy is an underestimated - likely due to inappropriate clinical trials - but serious disease condition because it promotes the development of atherosclerosis in large arterial vessels, vasomotor dysfunction in microvessels, hypertension and thrombosis. In this review, we will summarize previous functional findings focusing on coronary vessels and cardiac function and the underlying cellular and molecular mechanisms enabling the development of novel treatments.
C1 [Koller, Akos; Lelbach, Adam] Univ Phys Educ, Inst Nat Sci, Res Grp Sportgenet & Sportgerontol, Budapest, Hungary.
   [Koller, Akos] New York Med Coll, Dept Physiol, Valhalla, NY 10595 USA.
   [Koller, Akos] Univ Pecs, Inst Neurosurg, Med Sch, Pecs, Hungary.
   [Koller, Akos; Szenasi, Annamaria; Lelbach, Adam] Semmelweis Univ, Dept Pathophysiol, Budapest, Hungary.
   [Koller, Akos; Szenasi, Annamaria; Dornyei, Gabriella] Semmelweis Univ, Dept Morphol & Physiol, Fac Hlth Sci, Budapest, Hungary.
   [Kovacs, Nora] Klinikum Ingolstadt, Med Klin 1, Ingolstadt, Germany.
   [Lelbach, Adam] Rose Private Hosp, Budapest, Hungary.
   [Kovacs, Imre] Sopron Hlth Ctr, Dept Internal Med Cardiol, Sopron, Hungary.
C3 University of Physical Education; New York Medical College; University
   of Pecs; Semmelweis University; Semmelweis University
RP Koller, A (corresponding author), Univ Phys Educ, Inst Nat Sci, Res Grp Sportgenet & Sportgerontol, Budapest, Hungary.; Koller, A (corresponding author), New York Med Coll, Dept Physiol, Valhalla, NY 10595 USA.
EM akos.koller@gmail.com
RI Ákos, Koller/Q-4672-2019
FU NKFIH, Hungarian Scientific Research Funds (OTKA) [K108444]; National
   Institutes of Health (NIH) [HL-46813]
FX The writing of this review was supported by the NKFIH, Hungarian
   Scientific Research Funds (OTKA) K108444 and National Institutes of
   Health (NIH) HL-46813. We acknowledge Dr. Zoltan Veresh for the esthetic
   design of Fig. (4).
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NR 124
TC 28
Z9 31
U1 0
U2 23
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1381-6128
EI 1873-4286
J9 CURR PHARM DESIGN
JI Curr. Pharm. Design
PY 2018
VL 24
IS 25
BP 2911
EP 2920
DI 10.2174/1381612824666180625125450
PG 10
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA HA2MQ
UT WOS:000450073300005
PM 29938610
DA 2025-06-11
ER

PT J
AU Tang, S
   Wang, BT
   Liu, X
   Xi, WX
   Yue, YY
   Tan, X
   Bai, JY
   Huang, LH
AF Tang, Sheng
   Wang, Botao
   Liu, Xin
   Xi, Wenxia
   Yue, Yuanyuan
   Tan, Xiang
   Bai, Junying
   Huang, Linhua
TI Structural insights and biological activities of flavonoids:
   Implications for novel applications
SO FOOD FRONTIERS
LA English
DT Review
DE application; biosynthesis; flavonoids; metabolism; structure;
   structure-activity relationship
ID IN-VITRO; ANTIBACTERIAL ACTIVITIES; ANTIMICROBIAL ACTIVITY; METABOLIC
   SYNDROME; OXIDATIVE STRESS; AUXIN TRANSPORT; HEAT-TREATMENT;
   CANCER-CELLS; APIGENIN; ANTIOXIDANT
AB Flavonoids are a major class of polyphenolic compounds that occur naturally in plants and are widely distributed in various dietary products. Flavonoids exhibit prominent physicochemical properties and biological activities, thereby garnering considerable attention. Notably, the physicochemical properties and functionalities of flavonoids are structurally dependent. Variations in chemical structure lead to differences in physicochemical characteristics among different flavonoid types. Structural alterations can modify these characteristics, influencing biological activities and mechanisms of action. However, these structural variations and their biological implication have not been comprehensively elucidated. In this review, we outline the structural characteristics of flavonoids, discuss biosynthesis, in vivo digestion, and absorption, and particularly emphasize the diverse biological activities and action mechanisms associated with different flavonoid structures. By summarizing the current scientific findings, we aim to elucidate the structure-activity relationships of flavonoids and provide a theoretical basis for the development of new flavonoid applications, which will help to target the design of functional molecules and moieties in the food and pharmaceutical industries for use in drug design and development.Practical Application: Understanding the structural characteristics and biological activities of flavonoids can guide the development of functional food products and dietary supplements with targeted health benefits. By leveraging the knowledge of flavonoid structure-activity relationships, food, and pharmaceutical industries can innovate formulations to enhance bioavailability and efficacy, potentially leading to the creation of tailored products for specific health conditions or dietary needs. This research lays the groundwork for the design of novel flavonoid-based interventions aimed at promoting human health and well-being.
   It provides a theoretical basis for the development of new applications of flavonoids and facilitates the targeted functional molecular design and development in the food and pharmaceutical industries. In this paper, the structural characteristics of flavonoids were summarized, and the biosynthesis, digestion and absorption of flavonoids in vivo were discussed, with emphasis on the different biological activities and mechanisms of flavonoids with different structures. By summarizing the current scientific research results, the structure-activity relationship of flavonoids was elucidated. image
C1 [Tang, Sheng; Liu, Xin; Xi, Wenxia; Yue, Yuanyuan; Tan, Xiang; Bai, Junying; Huang, Linhua] Southwest Univ, Citrus Res Inst, Chongqing 400700, Peoples R China.
   [Wang, Botao] Bloomage Biotechnol Co Ltd, Jinan, Peoples R China.
   [Tang, Sheng; Liu, Xin; Tan, Xiang; Bai, Junying; Huang, Linhua] Natl Citrus Engn Res Ctr, Chongqing, Peoples R China.
   [Xi, Wenxia; Yue, Yuanyuan] Shihezi Univ, Sch Food Sci & Technol, Shihezi, Peoples R China.
C3 Southwest University - China; Shihezi University
RP Bai, JY; Huang, LH (corresponding author), Southwest Univ, Citrus Res Inst, Chongqing 400700, Peoples R China.
EM baijunying@swu.edu.cn; huanglh@cric.cn
RI Wang, Botao/N-4364-2016; Bai, Junying/GRN-9783-2022; 刘, 鑫/GVU-8359-2022;
   Sheng, Tang/JVZ-2962-2024
OI Bai, Junying/0000-0002-4401-4207; Tang, Sheng/0009-0006-7484-518X
FU Chongqing Graduate Student Research Innovation Program [CYS240197]; The
   "Pioneer" and "Leading Goose" R&D Program of Zhejiang [2022C02012];
   Fundamental Research Funds for the Central Universities [SWU-KQ22076]
FX Chongqing Graduate Student Research Innovation Program, Grant/Award
   Number: CYS240197; The "Pioneer" and "Leading Goose" R&D Program of
   Zhejiang, Grant/Award Number: 2022C02012; Fundamental Research Funds for
   the Central Universities, Grant/Award Number: SWU-KQ22076
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NR 264
TC 3
Z9 3
U1 21
U2 29
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
EI 2643-8429
J9 FOOD FRONTIERS
JI Food Frontiers
PD JAN
PY 2025
VL 6
IS 1
BP 218
EP 247
DI 10.1002/fft2.494
EA OCT 2024
PG 30
WC Food Science & Technology
WE Emerging Sources Citation Index (ESCI)
SC Food Science & Technology
GA S1C9K
UT WOS:001332681100001
OA gold
DA 2025-06-11
ER

PT J
AU Samanta, S
AF Samanta, Saptadip
TI Potential Impacts of Prebiotics and Probiotics on Cancer Prevention
SO ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
LA English
DT Review
DE Gut microbiota; dysbiosis; cancer; prebiotics; probiotics; immunotherapy
ID INTERNATIONAL SCIENTIFIC ASSOCIATION; LACTOBACILLUS-RHAMNOSUS GG; HUMAN
   COLONIC MICROBIOTA; CELL-CYCLE PROGRESSION; CENTRAL-NERVOUS-SYSTEM;
   LACTIC-ACID BACTERIA; HUMAN GUT MICROBIOTA; CHAIN FATTY-ACIDS;
   ROR-GAMMA-T; COLORECTAL-CANCER
AB Background: Cancer is a serious problem throughout the world. The pathophysiology of cancer is multifactorial and is also related to gut microbiota. Intestinal microbes are the useful resident of the healthy human. They are significant for various aspects of human health, including nutritional biotransformation, flushing of the pathogens, toxin neutralization, immune response, and onco-suppression. Disruption in the interactions among the gut microbiota, intestinal epithelium, and the host immune system are associated with gastrointestinal disorders, neurodegenerative diseases, metabolic syndrome, and cancer. Probiotic bacteria (Lactobacillus spp., Bifidobacterium spp.) have been regarded as beneficial to health. Moreover, they also play a significant role in immunomodulation and a preventive measure against obesity, diabetes, liver disease, inflammatory bowel disease, tumor progression, and cancer.
   Objective: The involvement of gut microorganisms in cancer development and prevention has been recognized as a balancing factor. The events of dysbiosis emphasize metabolic disorder and carcinogenesis. The gut flora potentiates immunomodulation and minimizes the limitations of usual chemotherapy. The significant role of prebiotics and probiotics on the improvement of immunomodulation and antitumor properties has been considered.
   Methods: I had reviewed the literature on the multidimensional activities of prebiotics and probiotics from the NCBI website database PubMed, Springer Nature, Science Direct (Elsevier), Google Scholar database to search relevant articles. Specifically, I had focused on the role of prebiotics and probiotics in immunomodulation and cancer prevention.
   Results: Prebiotics are the nondigestible fermentable sugars that selectively influence the growth of probiotic organisms that exert immunomodulation over the cancerous growth. The oncostatic properties of bacteria are mediated through the recruitment of cytotoxic T cells, natural killer cells, and oxidative stress-induced apoptosis in the tumor microenvironment. Moreover, approaches have also been taken to use probiotics as an adjuvant in cancer therapy.
   Conclusion: The present review has indicated that dysbiosis is a crucial factor in many pathological situations, including cancer. Applications of prebiotics and probiotics exhibit the immune-surveillance as oncostatic effects. These events increase the possibilities of new therapeutic strategies for cancer prevention.
C1 [Samanta, Saptadip] Midnapore Coll, Dept Physiol, Midnapore 721101, W Bengal, India.
C3 Midnapore College
RP Samanta, S (corresponding author), Midnapore Coll, Dept Physiol, Midnapore 721101, W Bengal, India.
EM saptadip174@gmail.com
OI Samanta, Saptadip/0000-0001-6741-699X
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NR 298
TC 36
Z9 39
U1 1
U2 36
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1871-5206
EI 1875-5992
J9 ANTI-CANCER AGENT ME
JI Anti-Cancer Agents Med. Chem.
PD FEB
PY 2022
VL 22
IS 4
BP 605
EP 628
DI 10.2174/1871520621999201210220442
PG 24
WC Oncology; Chemistry, Medicinal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Pharmacology & Pharmacy
GA 2U4EK
UT WOS:000823112700002
PM 33305713
DA 2025-06-11
ER

PT J
AU Ferreira, RD
   Mendonça, LABM
   dos Santos, C
   Hiane, PA
   Matias, R
   Franco, OL
   de Oliveira, AKM
   do Nascimento, VA
   Pott, A
   Carvalho, CME
   Guimaraes, RDA
AF Ferreira, Rosangela dos Santos
   Mendonca, Ligia Aurelio Bezerra Maranhao
   dos Santos, Cristiane
   Hiane, Priscila Aiko
   Matias, Rosemary
   Franco, Octavio Luiz
   de Oliveira, Ademir Kleber Morbeck
   do Nascimento, Valter Aragao
   Pott, Arnildo
   Carvalho, Cristiano Marcelo Espinola
   Guimaraes, Rita de Cassia Avellaneda
TI Do Bioactive Food Compound with Avena sativa L., Linum
   usitatissimum L. and Glycine max L. Supplementation with
   Moringa oleifera Lam. Have a Role against Nutritional Disorders?
   An Overview of the In Vitro and In Vivo Evidence
SO NUTRIENTS
LA English
DT Review
DE oat; flaxseed; soya; M; oleifera; nutraceuticals; non-transmissible
   chronical diseases; intestinal inflammatory diseases; malnutrition;
   intestinal microbiota
ID HUMAN GUT MICROBIOME; BLOOD-PRESSURE; LIPID PROFILE; DIETARY FIBER;
   BETA-GLUCANS; FLAXSEED OIL; SOY INTAKE; ULCERATIVE-COLITIS;
   COLORECTAL-CANCER; OXIDATIVE STRESS
AB Functional clinical nutrition is an integrative science; it uses dietary strategies, functional foods and medicinal plants, as well as combinations thereof. Both functional foods and medicinal plants, whether associated or not, form nutraceuticals, which can bring benefits to health, in addition to being included in the prevention and treatment of diseases. Some functional food effects from Avena sativa L. (oats), Linum usitatissimum L. (brown flaxseed), Glycine max L. (soya) and Moringa oleifera have been proposed for nutritional disorders through in vitro and in vivo tests. A formulation called a bioactive food compound (BFC) showed efficiency in the association of oats, flaxseed and soy for dyslipidemia and obesity. In this review, we discuss the effects of BFC in other nutritional disorders, as well as the beneficial effects of M. oleifera in obesity, cardiovascular disease, diabetes mellitus type 2, metabolic syndrome, intestinal inflammatory diseases/colorectal carcinogenesis and malnutrition. In addition, we hypothesized that a BFC enriched with M. oleifera could present a synergistic effect and play a potential benefit in nutritional disorders. The traditional consumption of M. oleifera preparations can allow associations with other formulations, such as BFC. These nutraceutical formulations can be easily accepted and can be used in sweet preparations (fruit and/or vegetable juices, fruit and/or vegetable vitamins, porridges, yogurt, cream, mousses or fruit salads, cakes and cookies) or savory (vegetable purees, soups, broths and various sauces), cooked or not. These formulations can be low-cost and easy-to-use. The association of bioactive food substances in dietary formulations can facilitate adherence to consumption and, thus, contribute to the planning of future nutritional interventions for the prevention and adjuvant treatment of the clinical conditions presented in this study. This can be extended to the general population. However, an investigation through clinical studies is needed to prove applicability in humans.
C1 [Ferreira, Rosangela dos Santos; Mendonca, Ligia Aurelio Bezerra Maranhao; dos Santos, Cristiane; Franco, Octavio Luiz; Carvalho, Cristiano Marcelo Espinola] Catholic Univ Dom Bosco UCDB, Grad Program Biotechnol, S Inova Biotech, BR-79117010 Campo Grande, MS, Brazil.
   [Hiane, Priscila Aiko; do Nascimento, Valter Aragao; Guimaraes, Rita de Cassia Avellaneda] Fed Univ Mato Grosso Sul UFMS, Grad Program Hlth & Dev Cent West Reg Brazil, BR-79079900 Campo Grande, MS, Brazil.
   [Matias, Rosemary; de Oliveira, Ademir Kleber Morbeck] Univ Anhanguera Uniderp, Grad Program Environm & Reg Dev, BR-79035470 Campo Grande, MS, Brazil.
   [Franco, Octavio Luiz] Catholic Univ Brazilia, Grad Program Genom Sci & Biotechnol, Ctr Prote & Biochem Anal, BR-70790160 Brasilia, DF, Brazil.
   [Pott, Arnildo] Fed Univ Mato Grosso Sul UFMS, Inst Biosci, BR-79079900 Campo Grande, MS, Brazil.
C3 Universidade Federal de Mato Grosso do Sul; Universidade Anhanguera;
   Universidade Federal de Mato Grosso do Sul
RP Guimaraes, RDA (corresponding author), Fed Univ Mato Grosso Sul UFMS, Grad Program Hlth & Dev Cent West Reg Brazil, BR-79079900 Campo Grande, MS, Brazil.
EM rosangela.ferreira@ufms.br; lmendoncanutri@gmail.com;
   cristinyba@gmail.com; priscila.hiane@ufms.br; mdr@anhanguera.com;
   ocfranco@gmail.com; akmorbeckoliveira@gmail.com; aragao60@hotmail.com;
   arnildo.pott@gmail.com; cristiano@ucdb.br; ritaaguimaraes@gmail.com
RI Guimarães, Rita de Cássia/JVO-6281-2024; Franco, Octavio/T-3020-2017;
   Nascimento, Valter Aragão do Nascimento/HDM-7086-2022; POTT,
   ARNILDO/I-5759-2012; Oliveira, Ademir/AGR-2641-2022; Carvalho,
   Cristiano/F-9862-2016
OI Pott, Arnildo/0000-0002-8599-9276; Ferreira,
   Rosangela/0000-0001-6965-6639; Nascimento, Valter/0000-0002-9020-8002;
   dos Santos, Cristiane/0000-0002-2537-758X; Carvalho,
   Cristiano/0000-0002-3867-9528; Franco, Octavio/0000-0001-9546-0525;
   Morbeck de Oliveira, Ademir Kleber/0000-0001-9373-9573
FU Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior, Brazil
   (CAPES) [001]
FX This study was financed in part by the Coordenacao de Aperfeicoamento de
   Pessoal de Nivel Superior, Brazil (CAPES)-Finance Code 001.
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NR 197
TC 2
Z9 2
U1 2
U2 20
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JUL
PY 2021
VL 13
IS 7
AR 2294
DI 10.3390/nu13072294
PG 22
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA TP1CM
UT WOS:000677336100001
PM 34371804
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Milajerdi, A
   Larijani, B
   Esmaillzadeh, A
AF Milajerdi, Alireza
   Larijani, Bagher
   Esmaillzadeh, Ahmad
TI Statins influence biomarkers of low grade inflammation in apparently
   healthy people or patients with chronic diseases: A systematic review
   and meta-analysis of randomized clinical trials
SO CYTOKINE
LA English
DT Review
DE Cytokines; Healthy; Inflammation; Meta-analysis; Statins
ID C-REACTIVE PROTEIN; ENDOTHELIAL FUNCTION; METABOLIC SYNDROME; PRIMARY
   PREVENTION; OXIDATIVE STRESS; ATORVASTATIN 10; PPAR-ALPHA; SIMVASTATIN;
   SENSITIVITY; MICE
AB Background: No earlier study summarized findings on the effect of statins on inflammatory biomarkers in apparently healthy individuals or those with chronic diseases. This study was done to systematically review earlier publications on the effect of statins on serum concentrations of C-reactive protein (CRP) and Interleukin-6 (IL-6) in apparently healthy individuals or those with chronic diseases.
   Methods: We searched relevant publications published up to December 2018 in PubMed, MEDLINE, SCOPUS, EMBASE, and Google Scholar databases. For this purpose, suitable MESH and non-MESH keywords were used. Randomized placebo-controlled clinical trials that examined the effect of statins on serum concentrations of CRP and IL-6 in apparently healthy adults or those with chronic diseases were included.
   Results: Overall, 18 studies with 23 effect sizes, that enrolled 32,156 individuals (38% female and 62% male; mean age: 44.79 years) were included. When we combined 21 effect sizes from 16 studies, we observed a significant reduction in circulating levels of CRP following administration of statins [Weighted Mean Difference (WMD): 0.80; 95% CI: 1.05, 0.56]. Combining 12 effect sizes from 11 studies, a significant reduction was found in serum CRP concentrations following administration of Atorvastatin (WMD: 0.57; 95% CI: 0.78, 0.35). Pooling 5 effect sizes from 2 studies, we found a significant reduction in serum concentrations of CRP following administration of Simvastatin (WMD: 0.29; 95% CI: 0.49, 0.10; I-2 = 88.5%). Combining 6 effect sizes from 5 studies, we found a significant reduction in serum IL-6 concentrations after Atorvastatin therapy (WMD: 2.13; 95% CI: 3.96, 0.30; I-2 = 98.6%).
   Conclusions: In conclusion, we found that statins administration in apparently healthy people or those with chronic diseases help reducing serum CRP concentrations. In addition, Atorvastatin administration resulted in reduced serum IL-6 concentrations in these people.
C1 [Milajerdi, Alireza; Esmaillzadeh, Ahmad] Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Community Nutr, POB 14155-6117, Tehran, Iran.
   [Milajerdi, Alireza] Tehran Univ Med Sci, SSRC, Tehran, Iran.
   [Larijani, Bagher] Univ Tehran Med Sci, Endocrinol & Metab Res Ctr, Endocrinol & Metab Clin Sci Inst, Tehran, Iran.
   [Esmaillzadeh, Ahmad] Univ Tehran Med Sci, Obes & Eating Habits Res Ctr, Endocrinol & Metab Mol Cellular Sci Inst, Tehran, Iran.
   [Esmaillzadeh, Ahmad] Isfahan Univ Med Sci, Sch Nutr & Food Sci, Dept Community Nutr, Food Secur Res Ctr, Esfahan, Iran.
C3 Tehran University of Medical Sciences; Tehran University of Medical
   Sciences; Tehran University of Medical Sciences; Tehran University of
   Medical Sciences; Isfahan University of Medical Sciences
RP Esmaillzadeh, A (corresponding author), Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Community Nutr, POB 14155-6117, Tehran, Iran.
EM a-esmaillzadeh@tums.ac.ir
RI Milajerdi, Alireza/ABB-1854-2020; Esmaillzadeh, Ahmad/N-5704-2014;
   larijani, Bagher/ABE-3315-2020
OI Larijani, Bagher/0000-0001-5386-7597
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NR 51
TC 26
Z9 26
U1 1
U2 12
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 1043-4666
EI 1096-0023
J9 CYTOKINE
JI Cytokine
PD NOV
PY 2019
VL 123
AR 154752
DI 10.1016/j.cyto.2019.154752
PG 13
WC Biochemistry & Molecular Biology; Cell Biology; Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology; Immunology
GA JA1KR
UT WOS:000487576400009
PM 31228727
DA 2025-06-11
ER

PT J
AU Liu, G
   Deng, YY
   Sun, L
   Ye, XW
   Yao, P
   Hu, Y
   Wang, FJ
   Ma, YW
   Li, HX
   Liu, Y
   Sun, Q
   Lin, X
AF Liu, Gang
   Deng, Yueyi
   Sun, Liang
   Ye, Xingwang
   Yao, Pang
   Hu, Yao
   Wang, Feijie
   Ma, Yiwei
   Li, Huaixing
   Liu, Yong
   Sun, Qi
   Lin, Xu
TI Elevated plasma tumor necrosis factor-α receptor 2 and resistin are
   associated with increased incidence of kidney function decline in
   Chinese adults
SO ENDOCRINE
LA English
DT Article
DE Adipokines; Inflammatory markers; Prospective study; Kidney function
   decline
ID GLOMERULAR-FILTRATION-RATE; IMPROVING GLOBAL OUTCOMES; C-REACTIVE
   PROTEIN; METABOLIC SYNDROME; OLDER CHINESE; CARDIOVASCULAR-DISEASE;
   POSITION STATEMENT; RENAL DYSFUNCTION; ENDOTHELIAL-CELLS; OXIDATIVE
   STRESS
AB Adipokines and inflammatory markers have been linked to kidney disease in animal models; however, evidence from prospective human studies is sparse. Recruited from Beijing and Shanghai in 2005, a total number of 2220 non-institutionalized Chinese individuals aged 50-70 years with baseline estimated glomerular filtration rate (eGFR) > 60 mL/min/1.73 m(2) were prospectively followed for 6 years. Plasma levels of resistin, retinol-binding protein 4 (RBP4), interleukin-6 (IL-6), C-reactive protein (CRP), and tumor necrosis factor-alpha receptor 2 (TNF-R2) were determined at baseline. Kidney function decrease was assessed by measurements of eGFR over 6 years. Incident-reduced eGFR was defined as the onset of eGFR < 60 mL/min/1.73 m(2), according to the Modification of Diet in Renal Disease Study Equation for Chinese. During the 6 years of follow-up, 333 (15.0 %) participants had incident-reduced eGFR. Each 1 standard deviation elevated concentration of resistin [relative risk (RR) 1.10; 95 % CI 1.00-1.24] and TNFR-2 (RR 1.30; 95 % CI 1.13-1.49) at baseline were significantly associated with a higher risk of incident-reduced eGFR. Comparing the highest with the lowest quartiles, the RR of incident-reduced eGFR was 1.43 (95 % CI 1.01-2.03) for resistin and 2.03 (95 % CI 1.41-2.93) for TNF-R2 (both P (trend) < 0.05) after adjustment for baseline demographic characteristics, lifestyle behaviors, BMI, plasma lipid profile, hypertension, and diabetes. These associations remained significant when further controlling for levels of RBP4, IL-6, and CRP, none of which was significantly associated with the risk of incident-reduced eGFR. In this prospective cohort study, elevated levels of resistin and TNF-R2, but not other adipokines and inflammatory markers, were independently associated with a greater risk of kidney function decline in middle-aged and elderly Chinese.
C1 [Liu, Gang; Sun, Liang; Ye, Xingwang; Yao, Pang; Hu, Yao; Wang, Feijie; Ma, Yiwei; Li, Huaixing; Liu, Yong; Lin, Xu] Chinese Acad Sci, Key Lab Nutr & Metab, Inst Nutr Sci, Shanghai Inst Biol Sci, 320 Yue Yang Rd, Shanghai 200031, Peoples R China.
   [Liu, Gang; Sun, Liang; Ye, Xingwang; Yao, Pang; Hu, Yao; Wang, Feijie; Ma, Yiwei; Li, Huaixing; Liu, Yong; Lin, Xu] Univ Chinese Acad Sci, 320 Yue Yang Rd, Shanghai 200031, Peoples R China.
   [Deng, Yueyi] Shanghai Univ Tradit Chinese Med, Longhua Hosp, Dept Nephrol, Shanghai, Peoples R China.
   [Sun, Qi] Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA.
   [Sun, Qi] Brigham & Womens Hosp, Dept Med, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA.
   [Sun, Qi] Harvard Univ, Sch Med, Boston, MA USA.
C3 Chinese Academy of Sciences; Chinese Academy of Sciences; University of
   Chinese Academy of Sciences, CAS; Shanghai University of Traditional
   Chinese Medicine; Harvard University; Harvard T.H. Chan School of Public
   Health; Harvard University; Harvard University Medical Affiliates;
   Brigham & Women's Hospital; Harvard University; Harvard Medical School
RP Lin, X (corresponding author), Chinese Acad Sci, Key Lab Nutr & Metab, Inst Nutr Sci, Shanghai Inst Biol Sci, 320 Yue Yang Rd, Shanghai 200031, Peoples R China.; Lin, X (corresponding author), Univ Chinese Acad Sci, 320 Yue Yang Rd, Shanghai 200031, Peoples R China.; Sun, Q (corresponding author), Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA.; Sun, Q (corresponding author), Brigham & Womens Hosp, Dept Med, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA.; Sun, Q (corresponding author), Harvard Univ, Sch Med, Boston, MA USA.
EM qisun@hsph.harvard.edu; xlin@sibs.ac.cn
RI 马, 一巍/ABH-8745-2022; Liu, Gang/H-6420-2019; Sun, Qi/KHT-5120-2024; Ye,
   Xingwang/D-5193-2011; Li, Xiaoying/GYA-2677-2022; Hu, Yao/L-1424-2019;
   lin, xu/KOC-3517-2024
OI Liu, Gang/0000-0002-1430-3016
FU Ministry of Science and Technology of China [2012CB524900,
   2013BAI04B03]; National Natural Science Foundation of China [81202272,
   81321062, 30930081, 81021002]; International Postdoctoral Exchange
   Fellowship Program; Knowledge Innovation Program of Shanghai Institutes
   for Biological Sciences; Chinese Academy of Sciences [2013KIP107];
   SA-SIBS Scholarship Program;  [ZY3-CCCX-3-2001]; 
   [ZYSNXD-CC-HPGC-JD-003]
FX This study was supported by the Ministry of Science and Technology of
   China (2012CB524900 and 2013BAI04B03); the National Natural Science
   Foundation of China (81202272, 81321062, 30930081, and 81021002);
   ZY3-CCCX-3-2001, ZYSNXD-CC-HPGC-JD-003; the International Postdoctoral
   Exchange Fellowship Program 2015; the Knowledge Innovation Program of
   Shanghai Institutes for Biological Sciences; Chinese Academy of Sciences
   [2013KIP107]; and the SA-SIBS Scholarship Program.
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NR 50
TC 14
Z9 14
U1 0
U2 11
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1355-008X
EI 1559-0100
J9 ENDOCRINE
JI Endocrine
PD JUN
PY 2016
VL 52
IS 3
BP 541
EP 549
DI 10.1007/s12020-015-0807-3
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA DM9ER
UT WOS:000376668100015
PM 26590599
DA 2025-06-11
ER

PT J
AU Fitó, M
   Estruch, R
   Salas-Salvadó, J
   Martínez-Gonzalez, MA
   Arós, F
   Vila, J
   Corella, D
   Díaz, O
   Sáez, G
   de la Torre, R
   Mitjavila, MT
   Muñoz, MA
   Lamuela-Raventós, RM
   Ruiz-Gutierrez, V
   Fiol, M
   Gómez-Gracia, E
   Lapetra, J
   Ros, E
   Serra-Majem, L
   Covas, MI
AF Fito, Montserrat
   Estruch, Ramon
   Salas-Salvado, Jordi
   Angel Martinez-Gonzalez, Miguel
   Aros, Fernando
   Vila, Joan
   Corella, Dolores
   Diaz, Oscar
   Saez, Guillermo
   de la Torre, Rafael
   Mitjavila, Maria-Teresa
   Angel Munoz, Miguel
   Lamuela-Raventos, Rosa-Maria
   Ruiz-Gutierrez, Valentina
   Fiol, Miquel
   Gomez-Gracia, Enrique
   Lapetra, Jose
   Ros, Emilio
   Serra-Majem, Lluis
   Covas, Maria-Isabel
CA PREDIMED Study Investigators
TI Effect of the Mediterranean diet on heart failure biomarkers: a
   randomized sample from the PREDIMED trial
SO EUROPEAN JOURNAL OF HEART FAILURE
LA English
DT Article
DE urinary albumin; N-terminal pro-brain natriuretic peptide;
   albumin/creatinine ratio; lipoprotein a; oxidized LDL; Heart failure
ID LOW-DENSITY-LIPOPROTEIN; BRAIN NATRIURETIC PEPTIDE; METABOLIC SYNDROME;
   CARDIOVASCULAR-DISEASE; PLASMA-CONCENTRATIONS; OXIDATIVE STRESS; WOMEN;
   RISK; EPIDEMIOLOGY; INFLAMMATION
AB Aims
   Scarce data are available on the effect of the traditional Mediterranean diet (TMD) on heart failure biomarkers. We assessed the effect of TMD on biomarkers related to heart failure in a high cardiovascular disease risk population.
   Methods and Results
   A total of 930 subjects at high cardiovascular risk (420 men and 510 women) were recruited in the framework of a multicentre, randomized, controlled, parallel-group clinical trial directed at testing the efficacy of the TMD on the primary prevention of cardiovascular disease (The PREDIMED Study). Participants were assigned to a low-fat diet (control, n = 310) or one of two TMDs [TMD + virgin olive oil (VOO) or TMD + nuts]. Depending on group assignment, participants received free provision of extra-virgin olive oil, mixed nuts, or small non-food gifts. After 1 year of intervention, both TMDs decreased plasma N-terminal pro-brain natriuretic peptide, with changes reaching significance vs. control group (P < 0.05). Oxidized low-density lipoprotein decreased in both TMD groups (P < 0.05), the decrease in TMD + VOO group reaching significance vs. changes in control group (P = 0.003). Changes in lipoprotein(a) after TMD + VOO were less than those in the control group (P = 0.046) in which an increase (P = 0.035) was observed. No changes were observed in urinary albumin or albumin/creatinine ratio.
   Conclusions
   Individuals at high risk of cardiovascular disease (CVD) who improved their diet toward a TMD pattern reduced their N-terminal pro-brain natriuretic peptide compared with those assigned to a low-fat diet. The same was found for in vivo oxidized low-density lipoprotein and lipoprotein(a) plasma concentrations after the TMD + VOO diet. From our results TMD could be a useful tool to mitigate against risk factors for heart failure. From our results TMD could modify markers of heart failure towards a more protective mode.
C1 [Fito, Montserrat; Diaz, Oscar; Covas, Maria-Isabel] Inst Hosp Mar Invest Biomed IMIM, Cardiovasc Risk & Nutr Res Grp, Barcelona, Spain.
   [Fito, Montserrat; Estruch, Ramon; Salas-Salvado, Jordi; Angel Martinez-Gonzalez, Miguel; Aros, Fernando; Corella, Dolores; Saez, Guillermo; de la Torre, Rafael; Lamuela-Raventos, Rosa-Maria; Ruiz-Gutierrez, Valentina; Fiol, Miquel; Gomez-Gracia, Enrique; Lapetra, Jose; Ros, Emilio; Serra-Majem, Lluis; Covas, Maria-Isabel] CIBER Fisiopatol Obesidad & Nutr CIBEROBN, Madrid, Spain.
   [Estruch, Ramon] Inst Invest Biomed August Pi Sunyer IDIBAPS, Dept Internal Med, Barcelona, Spain.
   [Salas-Salvado, Jordi] Univ Rovira & Virgili, Dept Human Nutr, E-43201 Reus, Spain.
   [Angel Martinez-Gonzalez, Miguel] Univ Navarra, Sch Med, Dept Prevent Med & Publ Hlth, E-31080 Pamplona, Spain.
   [Aros, Fernando] Univ Hosp Alava, Dept Cardiol, Vitoria, Spain.
   [Vila, Joan] Inst Hosp Mar Invest Biomed IMIM, Cardiovasc Epidemiol & Genet Res Grp, Barcelona, Spain.
   [Vila, Joan] CIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain.
   [Corella, Dolores] Univ Valencia, Dept Epidemiol, E-46003 Valencia, Spain.
   [Saez, Guillermo] Univ Valencia, Dept Biochem, Sch Med, E-46003 Valencia, Spain.
   [Saez, Guillermo] Univ Valencia, Dept Mol Biol, Sch Med, E-46003 Valencia, Spain.
   [de la Torre, Rafael] Inst Hosp Mar Invest Biomed IMIM, Human Neurosci Res Grp, Barcelona, Spain.
   [Mitjavila, Maria-Teresa] Univ Barcelona, INSA, Dept Physiol, E-08007 Barcelona, Spain.
   [Angel Munoz, Miguel] Catalan Inst Hlth, Barcelona, Spain.
   [Lamuela-Raventos, Rosa-Maria] Dept Nutr & Bromatol, Barcelona, Spain.
   [Ruiz-Gutierrez, Valentina] CSIC, Inst Grasa, E-41080 Seville, Spain.
   [Fiol, Miquel] Univ Balearic Isl, Inst Hlth Sci, Palma De Mallorca, Spain.
   [Gomez-Gracia, Enrique] Univ Malaga, Dept Epidemiol, E-29071 Malaga, Spain.
   [Lapetra, Jose] San Pablo Hlth Ctr, Seville, Spain.
   [Serra-Majem, Lluis] Univ Las Palmas Gran Canaria, Dept Clin Sci, Las Palmas Gran Canaria, Spain.
   [Ros, Emilio] Inst Invest Biomed August Pi Sunyer IDIBAPS, Dept Endocrinol & Nutr Hosp Clin, Barcelona, Spain.
C3 Hospital del Mar Research Institute; CIBER - Centro de Investigacion
   Biomedica en Red; CIBEROBN; University of Barcelona; Hospital Clinic de
   Barcelona; IDIBAPS; Universitat Rovira i Virgili; University of Navarra;
   Hospital del Mar Research Institute; CIBER - Centro de Investigacion
   Biomedica en Red; CIBERESP; University of Valencia; University of
   Valencia; University of Valencia; Hospital del Mar Research Institute;
   University of Barcelona; Consejo Superior de Investigaciones Cientificas
   (CSIC); CSIC - Instituto de la Grasa (IG); Universitat de les Illes
   Balears; Universidad de Malaga; Universidad de Las Palmas de Gran
   Canaria; University of Barcelona; Hospital Clinic de Barcelona; IDIBAPS
RP Fito, M (corresponding author), Inst Hosp Mar Invest Biomed IMIM, Cardiovasc Risk & Nutr Res Grp, Barcelona, Spain.
EM mfito@imim.es; mcovas@imim.es
RI Martinez-Gonzalez, Miguel/AAE-7669-2019; Diaz, Oscar/D-2822-2011;
   Lapetra, Jose/F-2552-2015; Serra-Majem, Lluis/I-6708-2019; Estruch,
   Ramon/AAZ-3723-2020; Mitjavila, Maria/D-7474-2014; Corella,
   Dolores/L-9888-2014; de la Torre, Rafael/D-3561-2018; Munoz,
   Miguel/LDF-8469-2024; Lamuela-Raventos, Rosa M/F-3986-2016; , MIQUEL
   FIOL SALA/F-6793-2016; Salas-Salvado, Jordi/C-7229-2017; Fito Colomer,
   Montse/C-1822-2012
OI Lamuela-Raventos, Rosa M/0000-0002-1287-4560; , MIQUEL FIOL
   SALA/0000-0002-5370-1391; Ros, Emilio/0000-0002-2573-1294;
   Salas-Salvado, Jordi/0000-0003-2700-7459; Serra-Majem,
   Lluis/0000-0002-9658-9061; Saez, Guillermo/0000-0002-8164-4048;
   Martinez-Gonzalez, Miguel A./0000-0002-3917-9808; Fito Colomer,
   Montse/0000-0002-1817-483X; de la Torre, Rafael/0000-0002-6765-1866;
   Vila-Domenech, Joan Salvador/0000-0002-0413-9291; Munoz,
   Miguel-Angel/0000-0002-4083-3248; Gomez Gracia,
   Enrique/0000-0002-1281-5798
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NR 30
TC 119
Z9 123
U1 0
U2 20
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1388-9842
EI 1879-0844
J9 EUR J HEART FAIL
JI Eur. J. Heart Fail.
PD MAY
PY 2014
VL 16
IS 5
BP 543
EP 550
DI 10.1002/ejhf.61
PG 8
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA AG5FG
UT WOS:000335444200008
PM 24574190
DA 2025-06-11
ER

PT J
AU Nilsson, AC
   Östman, EM
   Granfeldt, Y
   Björck, IME
AF Nilsson, Anne C.
   Ostman, Elin M.
   Granfeldt, Yvonne
   Bjorck, Inger M. E.
TI Effect of cereal test breakfasts differing in glycemic index and content
   of indigestible carbohydrates on daylong glucose tolerance in healthy
   subjects
SO AMERICAN JOURNAL OF CLINICAL NUTRITION
LA English
DT Article
DE GI; glycemic index; indigestible carbohydrates; second-meal effect;
   colonic fermentation; breath hydrogen
ID CORONARY-HEART-DISEASE; RESISTANT STARCH; CARDIOVASCULAR-DISEASE;
   INSULIN SENSITIVITY; OXIDATIVE STRESS; METABOLIC SYNDROME; DIETARY
   FIBER; WHOLE GRAINS; RISK; LOAD
AB Background: Frequent hyperglycemic episodes are increasingly being associated with an increased risk of type 2 diabetes and cardiovascular disease.
   Objective: We studied the extent to which acute glycemia and glycemia after subsequent meals can be modulated by the characteristics of cereal foods, such as glycemic index (GI) and content of indigestible carbohydrates.
   Design: Twelve healthy subjects consumed test meals in a random order. In series 1, the test meals were consumed at breakfast, and postprandial blood glucose incremental areas under the curve (IAUCs) were calculated after the test breakfast, standardized lunch, and standardized dinner. In series 2, the subjects consumed test evening meals and IAUCs were calculated after a subsequent standardized breakfast. Breath hydrogen was measured as an indicator of colonic fermentation.
   Results: Barley or rye kernel breakfasts lowered the blood glucose IAUC (0-120 min) at breakfast, at a subsequent lunch, and the cumulative IAUCs (breakfast+ lunch+ dinner) when compared with white-wheat bread (P < 0.05). The lunch blood glucose IAUCs were positively correlated with breakfast IAUCs (r = 0.30, P < 0.05). Breath hydrogen excretion was negatively correlated with blood glucose IAUCs after lunch (r = -0.33, P < 0.05) and dinner (r = -0.22, P < 0.05). A barley kernel evening meal resulted in lower IAUCs (P < 0.05) and higher breath hydrogen (P < 0.001) after a subsequent breakfast compared with white-wheat bread.
   Conclusions: Glucose tolerance at subsequent meals can be notably improved during the course of a whole day or overnight by choosing specific low-GI, whole-grain cereal products. A low GI may be sufficient to achieve a second-meal effect from breakfast to lunch. A specific indigestible carbohydrate mixture appears to be required to show benefits on glucose tolerance in a longer time frame (9.5 h), most likely mediated through colonic fermentation.
C1 [Nilsson, Anne C.; Ostman, Elin M.; Granfeldt, Yvonne; Bjorck, Inger M. E.] Lund Univ, Dept Food Technol Engn & Nutr, Div Appl Nutr & Food Chem, SE-22100 Lund, Sweden.
C3 Lund University
RP Nilsson, AC (corresponding author), Lund Univ, Dept Food Technol Engn & Nutr, Div Appl Nutr & Food Chem, POB 124, SE-22100 Lund, Sweden.
EM anne.nilsson@inl.lth.se
RI Nilsson, Anne/AIA-0822-2022; Ostman, Elin/G-3975-2012
OI Nilsson, Anne/0000-0002-9780-7876; Ostman, Elin/0000-0003-0831-6176
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NR 55
TC 132
Z9 146
U1 1
U2 37
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0002-9165
EI 1938-3207
J9 AM J CLIN NUTR
JI Am. J. Clin. Nutr.
PD MAR
PY 2008
VL 87
IS 3
BP 645
EP 654
DI 10.1093/ajcn/87.3.645
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 273KA
UT WOS:000253927700017
PM 18326603
OA Bronze
DA 2025-06-11
ER

EF﻿FN Clarivate Analytics Web of Science
VR 1.0
PT J
AU Zheng, YY
   Liu, WL
   Zhu, XY
   Xu, MY
   Lin, BH
   Bai, YS
AF Zheng, Yuyu
   Liu, Wanlu
   Zhu, Xinyu
   Xu, Mengya
   Lin, Baihao
   Bai, Yansen
TI Associations of dietary inflammation index and composite dietary
   antioxidant index with preserved ratio impaired spirometry in US adults
   and the mediating roles of triglyceride-glucose index: NHANES 2007-2012
SO REDOX BIOLOGY
LA English
DT Article
DE Dietary quality; Preserved ratio impaired spirometry;
   Triglyceride-glucose index; Mediation effects
ID LUNG-FUNCTION; METABOLIC SYNDROME; OXIDATIVE STRESS; HEALTH; RISK;
   CONSUMPTION; OUTCOMES; OBESITY; CANCER
AB Background Previous studies have shown that inflammatory and antioxidant dietary patterns can modify the risk of COPD, yet few studies have examined the association of these diets with its early signs (PRISm), and the potential role of metabolic disorders remains to be elucidated. Methods Data from 9529 individuals who participated in the 2007-2012 National Health and Nutrition Examination Survey (NHANES) were analyzed. The Dietary Inflammation Index (DII) and the Dietary Antioxidant Composite Index (CDAI) were assessed using 24-h dietary recall, multiple metabolic indicators were calculated according to biochemical markers, and lung function parameters defined PRISm cases. Individual and joint effects of DII and CDAI were evaluated by generalized linear models and binary logistic regression models, and mediation effects of metabolic indicators were further explored by causal mediation analysis. Results Increased DII was associated with decreased lung function (FEV1: beta = -18.82, FVC: beta = -29.2; OR = 1.04) and increased metabolic indicators (beta = 0.316, 0.036, 0.916, 0.033, and 0.145 on MAP, UA, TC, TyG, and MS, respectively). Contrary to this, CDAI were positively and negatively associated with lung function (FEV1: beta = 3.42; FVC: beta = 4.91; PRISm: OR = 0.99) and metabolic indicators (beta < 0), respectively. Joint effects of DII and CDAI indicated the minimal hazard effects of DII on TyG (beta = -0.11), FEV1 (beta = 72.62), FVC (beta = 122.27), and PRISm (OR = 0.79) in subjects with high CDAI when compared with those with low CDAI (low DII + high CDAI vs. high DII + low CDAI). Furthermore, TyG mediated 13.74 %, 8.29 %, and 21.70 % of DII- and 37.30 %, 20.90 %, and 12.32 % of CDAI-FEV1, -FVC, and -PRISm associations, respectively. Conclusions These findings indicated that CDAI can attenuate the adverse effects of DII on metabolic disorders and lung function decline, which provides new insight for diet modification in preventing early lung dysfunction.
C1 [Zheng, Yuyu; Liu, Wanlu; Zhu, Xinyu; Xu, Mengya; Lin, Baihao; Bai, Yansen] Guangzhou Med Univ, Sch Publ Hlth, Guangzhou 511436, Peoples R China.
C3 Guangzhou Medical University
RP Bai, YS (corresponding author), Guangzhou Med Univ, Inst Chem Carcinogenesis, Sch Publ Hlth, Guangzhou 511436, Peoples R China.
EM baiyansen6@163.com
RI Bai, Yansen/IYJ-8470-2023; Xu, Mengya/IWE-1897-2023; Zhu,
   Xinyu/MTF-3289-2025; Zheng, Yu-yu/AAX-6412-2021
FU National Natural Scientific Foundation of China [82203998]; The 2022
   Annual Student Innovation Capability Enhancement Program of Guangzhou
   Medical University; Scientific Research Project of Guangzhou Education
   Bureau [202235417]; Guangzhou Science and Tech-nology Project
   [2023A04J0560]
FX This work was supported by the National Natural Scientific Foundation of
   China (grant no. 82203998) , the 2022 Annual Student Innovation
   Capability Enhancement Program of Guangzhou Medical University, the
   Scientific Research Project of Guangzhou Education Bureau (grant no.
   202235417) , and the Guangzhou Science and Technology Project (grant no.
   2023A04J0560) .
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NR 71
TC 18
Z9 18
U1 7
U2 21
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2213-2317
J9 REDOX BIOL
JI Redox Biol.
PD OCT
PY 2024
VL 76
AR 103334
DI 10.1016/j.redox.2024.103334
EA AUG 2024
PG 9
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA F0A3V
UT WOS:001306532900001
PM 39217849
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Lewis, SE
   Li, LH
   Fazzari, M
   Salvatore, SR
   Li, J
   Hileman, EA
   Maxwell, BA
   Schopfer, FJ
   Arteel, GE
   Khoo, NKH
   Kelley, EE
AF Lewis, Sara E.
   Li, Lihua
   Fazzari, Marco
   Salvatore, Sonia R.
   Li, Jiang
   Hileman, Emily A.
   Maxwell, Brooke A.
   Schopfer, Francisco J.
   Arteel, Gavin E.
   Khoo, Nicholas K. H.
   Kelley, Eric E.
TI Obese female mice do not exhibit overt hyperuricemia despite hepatic
   steatosis and impaired glucose tolerance
SO ADVANCES IN REDOX RESEARCH
LA English
DT Article
DE Uric acid; Xanthine oxidoreductase; Female mice; Diet-induced obesity;
   Hepatic steatosis; Impaired glucose tolerance
ID FATTY LIVER-DISEASE; SERUM URIC-ACID; XANTHINE-OXIDASE ACTIVITY; DE-NOVO
   LIPOGENESIS; METABOLIC SYNDROME; OXIDATIVE STRESS; INSULIN; RISK;
   ASSOCIATION; SENSITIVITY
AB Recent reports have clearly demonstrated a tight correlation between obesity and elevated circulating uric acid levels (hyperuricemia). However, nearly all preclinical work in this area has been completed with male mice, leaving the field with a considerable gap in knowledge regarding female responses to obesity and hyperuricemia. This deficiency in sex as a biological variable extends beyond unknowns regarding uric acid (UA) to several important comorbidities associated with obesity including nonalcoholic fatty liver disease (NAFLD). To attempt to address this issue, herein we describe both phenotypic and metabolic responses to diet-induced obesity (DIO) in female mice. Six-week-old female C57BL/6J mice were fed a high-fat diet (60% calories derived from fat) for 32 weeks. The DIO female mice had significant weight gain over the course of the study, higher fasting blood glucose, impaired glucose tolerance, and elevated plasma insulin levels compared to age-matched on normal chow. While these classic indices of DIO and NAFLD were observed such as increased circulating levels of ALT and AST, there was no difference in circulating UA levels. Obese female mice also demonstrated increased hepatic triglyceride (TG), cholesterol, and cholesteryl ester. In addition, several markers of hepatic inflammation were significantly increased. Also, alterations in the expression of redox-related enzymes were observed in obese mice compared to lean controls including increases in extracellular superoxide dismutase (Sod3), heme oxygenase (Ho)- 1, and xanthine dehydrogenase (Xdh). Interestingly, hepatic UA levels were significantly elevated ( '2-fold) in obese mice compared to their lean counterparts. These data demonstrate female mice assume a similar metabolic profile to that reported in several male models of obesity in the context of alterations in glucose tolerance, hepatic steatosis, and elevated transaminases (ALT and AST) in the absence of hyperuricemia affirming the need for further study.
C1 [Li, Lihua; Fazzari, Marco; Salvatore, Sonia R.; Schopfer, Francisco J.; Khoo, Nicholas K. H.] Univ Pittsburgh, Dept Pharmacol & Chem Biol, 200 Lothrop St,E1340 Thomas E Starzl Biomed Sci To, Pittsburgh, PA 15261 USA.
   [Li, Jiang] Univ Pittsburgh, Div Gastroenterol Hepatol & Nutr, Pittsburgh, PA 15261 USA.
   [Schopfer, Francisco J.; Arteel, Gavin E.; Khoo, Nicholas K. H.] Univ Pittsburgh, Pittsburgh Liver Res Ctr, Pittsburgh, PA 15261 USA.
   [Lewis, Sara E.; Hileman, Emily A.; Maxwell, Brooke A.; Kelley, Eric E.] West Virginia Univ, Sch Med, Dept Physiol & Pharmacol, 3072B Hlth Sci Ctr,POB 9229, Morgantown, WV 26506 USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE); University
   of Pittsburgh; Pennsylvania Commonwealth System of Higher Education
   (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of
   Higher Education (PCSHE); University of Pittsburgh; West Virginia
   University
RP Khoo, NKH (corresponding author), Univ Pittsburgh, Dept Pharmacol & Chem Biol, 200 Lothrop St,E1340 Thomas E Starzl Biomed Sci To, Pittsburgh, PA 15261 USA.; Kelley, EE (corresponding author), West Virginia Univ, Sch Med, Dept Physiol & Pharmacol, 3072B Hlth Sci Ctr,POB 9229, Morgantown, WV 26506 USA.
EM nkhoo@pitt.edu; eric.kelley@hsc.wvu.edu
RI Marco, Fazzari/AAA-2229-2019; Arteel, Gavin/AAE-2440-2022; Schopfer,
   Francisco/AAW-6505-2021
OI Salvatore, Sonia/0000-0002-9942-3905
FU National Institute of Health (NIH) NKHK [R01 DK124510-01, R01
   HL153532-01A1, R21 NS112787, R01 AA028436, P30 DK120531, R01 GM125944,
   R01 DK112854]
FX This work was supported by National Institute of Health (NIH) R01
   DK124510-01 for NKHK; R01 DK124510-01, R01 HL153532-01A1, and AHA for
   EEK; R21 NS112787 for MAF; R01 AA028436 and P30 DK120531 for GEA; R01
   GM125944 and R01 DK112854 for FJS.
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NR 54
TC 3
Z9 3
U1 1
U2 1
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
EI 2667-1379
J9 ADV REDOX RES
JI Adv. Redox Res.
PD DEC
PY 2022
VL 6
AR 100051
DI 10.1016/j.arres.2022.100051
PG 8
WC Biochemistry & Molecular Biology
WE Emerging Sources Citation Index (ESCI)
SC Biochemistry & Molecular Biology
GA L6Q4I
UT WOS:001351940900010
PM 36561324
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Fitzgerald, DM
   Anderson, ST
   Sillence, MN
   de Laat, MA
AF Fitzgerald, Danielle M.
   Anderson, Stephen T.
   Sillence, Martin N.
   de Laat, Melody A.
TI The cresty neck score is an independent predictor of insulin
   dysregulation in ponies
SO PLOS ONE
LA English
DT Article
ID ORAL GLUCOSE TEST; ADIPOSE-TISSUE; ADIPONECTIN CONCENTRATIONS; ADIPOKINE
   CONCENTRATIONS; EXPRESSION PROFILES; OXIDATIVE STRESS; RISK-FACTORS; FAT
   MASS; BODY-FAT; HORSES
AB Generalized obesity, regional adiposity, hyperinsulinemia and hypertriglyceridemia are all potential indicators of equine metabolic syndrome (EMS). This study aimed to assess the relationship between morphometric measurements of body condition and metabolic hormone concentrations in ponies, with and without a neck crest or generalised obesity. Twenty-six ponies were assigned a body condition score (BCS) and cresty neck score (CNS). Height, girth, and neck measurements were taken. An oral glucose test (OGT; 0.75g dextrose/kg BW) was performed and blood samples collected prior to and 2 hours post dosing. Basal blood samples were analysed for blood glucose, serum insulin, triglyceride and leptin, and plasma HMW adiponectin concentrations. Post-prandial samples were analysed for serum insulin concentration. The ponies were grouped as having a) a normal to fleshy body status (BCS <= 7 and CNS <= 2; n = 10); b) having a high CNS, but without generalised obesity (BCS <= 7 and CNS >= 3; n = 11), or c) being obese (BCS >= 8 and CNS >= 1; n = 5). Responses to the OGT indicated that both normal and insulin-dysregulated ponies were included in the cohort. Post-prandial serum insulin was positively associated with CNS (P<0.035) and ponies with a CNS >= 3 had 5 times greater odds of being insulin-dysregulated. The high CNS group had a greater insulin response to the OGT than those in the normal/fleshy group (P = 0.006), whereas obese ponies did not differ from the other two groups. Basal HMW adiponectin was negatively correlated with post-prandial insulin concentrations (r = -0.5, P = 0.009), as well as being decreased in the group with a high CNS, compared to the obese group (P = 0.05). Cresty neck score was more predictive of insulin dysregulation than BCS, and this may be relevant to the diagnosis of EMS. Adiponectin may also be a measure of insulin dysregulation that is independent of body condition.
C1 [Fitzgerald, Danielle M.; Sillence, Martin N.; de Laat, Melody A.] Queensland Univ Technol, Earth Environm & Biol Sci Sch, Brisbane, Qld, Australia.
   [Anderson, Stephen T.] Univ Queensland, Sch Biomed Sci, St Lucia, Qld, Australia.
C3 Queensland University of Technology (QUT); University of Queensland
RP de Laat, MA (corresponding author), Queensland Univ Technol, Earth Environm & Biol Sci Sch, Brisbane, Qld, Australia.
EM melody.delaat@qut.edu.au
RI Fitzgerald, Danielle/MFH-7594-2025; de Laat, Melody/F-2899-2015;
   Anderson, Stephen/F-5281-2013
OI Fitzgerald, Danielle/0000-0002-5801-4427; de Laat,
   Melody/0000-0001-7922-3642; Anderson, Stephen/0000-0002-1176-4394
FU Animal Health Foundation, MO, USA; Queensland University of Technology
FX The study was funded by the Animal Health Foundation, MO, USA, and
   Queensland University of Technology.
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NR 51
TC 29
Z9 33
U1 1
U2 10
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JUL 24
PY 2019
VL 14
IS 7
AR e0220203
DI 10.1371/journal.pone.0220203
PG 15
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA IS7NE
UT WOS:000482335700067
PM 31339945
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Ramezani, M
   Zavattaro, E
   Sadeghi, M
AF Ramezani, Mazaher
   Zavattaro, Elisa
   Sadeghi, Masoud
TI Evaluation of serum lipid, lipoprotein, and apolipoprotein levels in
   psoriatic patients: a systematic review and meta-analysis of
   case-control studies
SO POSTEPY DERMATOLOGII I ALERGOLOGII
LA English
DT Review
DE psoriasis; serum; lipid; lipoprotein; apolipoprotein
ID CARDIOVASCULAR RISK-FACTORS; CHRONIC PLAQUE PSORIASIS; INTIMA-MEDIA
   THICKNESS; METABOLIC SYNDROME; INSULIN-RESISTANCE; OXIDATIVE STRESS;
   PROFILE; ASSOCIATION; SEVERITY; SMOKING
AB Introduction: Psoriasis is a T cell-mediated inflammatory skin disease in which fatty acids may be a link between psoriasis and its comorbidity.
   Aim: The present meta-analysis aimed to evaluate lipid, lipoprotein, and apolipoprotein levels in the psoriatic patients compared with the control subjects.
   Material and methods: Four databases, including Web of Science, Scopus, PubMed, and Cochrane Library were searched until July 2017. All records analysed were case-control studies. The quality of the questionnaires was evaluated using the Newcastle-Ottawa Scale (NOS). A random-effects meta-analysis was done by Rev Man 5.3 using mean difference (MD) and 95% confidence intervals (CIs).
   Results: Out of 580 studies identified in four databases, 49 studies were included and analysed in this met-analysis. The results showed that MD of total cholesterol, triglyceride, LDL, VLDL, HDL, Lp(a), Apo A1, and Apo B levels in the patients compared with the controls were (MD = 13.74 mg/dl; 95% CI: 7.72-19.75; p < 0.00001), (MD = 26.04 mg/dl; 95% CI: 20.77-31.31; p < 0.00001), (MD = 11.41 mg/dl; 95% CI: 6.26-16.57; p < 0.0001), (MD = 4.82 mg/dl; 95% CI: 3.63-6.00; p < 0.00001), (MD = -2.78 mg/dl; 95% CI: -4.53 --1.03; p < 0.002), (MD = 8.51 mg/dl; 95% CI: 4.86-12.17; p < 0.0001), (MD = -6.60 mg/dl; 95% CI: -13.96 - 0.75; p < 0.08), and (MD = 9.70 mg/dl; 95% CI: 3.02-16.39; p < 0.004), respectively.
   Conclusions: This meta-analysis identified abnormality of serum lipid, lipoprotein, and apolipoprotein profiles in psoriatic patients compared with the controls as well as possibly a greater risk of atherosclerosis and cardiovascular (CV) accidents in the patients.
C1 [Ramezani, Mazaher] Kermanshah Univ Med Sci, Imam Reza Hosp, Mol Pathol Res Ctr, Kermanshah, Iran.
   [Zavattaro, Elisa] Univ Eastern Piedmont Amedeo Avogadro, Dept Translat Med, Dermatol Unit, Novara, Italy.
   [Sadeghi, Masoud] Kermanshah Univ Med Sci, Med Biol Res Ctr, Kermanshah 671451673, Iran.
   [Sadeghi, Masoud] Kermanshah Univ Med Sci, Students Res Comm, Kermanshah, Iran.
C3 Kermanshah University of Medical Sciences; University of Eastern
   Piedmont Amedeo Avogadro; Kermanshah University of Medical Sciences;
   Kermanshah University of Medical Sciences
RP Sadeghi, M (corresponding author), Kermanshah Univ Med Sci, Med Biol Res Ctr, Kermanshah 671451673, Iran.
EM sadeghi_mbrc@yahoo.com
RI Zavattaro, Elisa/AAC-1099-2022; Ramezani, Mazaher/K-4440-2017; Sadeghi,
   Masoud/P-1546-2015
OI Sadeghi, Masoud/0000-0002-3586-3012
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NR 69
TC 25
Z9 28
U1 0
U2 1
PU TERMEDIA PUBLISHING HOUSE LTD
PI POZNAN
PA KLEEBERGA 2, POZNAN, 61-615, POLAND
SN 1642-395X
EI 2299-0046
J9 POSTEP DERM ALERGOL
JI Postep. Dermatol. Alergol.
PY 2019
VL 36
IS 6
BP 692
EP +
DI 10.5114/ada.2019.91420
PG 16
WC Allergy; Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Allergy; Dermatology
GA KB9SK
UT WOS:000506827300009
PM 31997997
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Koletzko, L
   Mahli, A
   Hellerbrand, C
AF Koletzko, Leandra
   Mahli, Abdo
   Hellerbrand, Claus
TI Development of an in vitro model to study hepatitis C virus effects on
   hepatocellular lipotoxicity and lipid metabolism
SO PATHOLOGY RESEARCH AND PRACTICE
LA English
DT Article
DE Hepatitis C; Genotype 1b; Hepatic steatosis; Oxidative stress;
   Lipogenesis
ID FATTY LIVER-DISEASE; INSULIN-RESISTANCE; STEATOSIS; EPIDEMIOLOGY;
   ACCUMULATION; EXPRESSION; NAFLD
AB Hepatic steatosis is common in patients infected with hepatitis C virus (HCV). Particularly in patients infected with non-genotype 3 HCV, hepatic steatosis is closely related to factors of the metabolic syndrome such as hyperlipidemia. However, the molecular mechanisms involved in this "metabolic" steatosis in non-3 genotype HCV infections are not well understood. Here, we aimed to develop an in vitro model to study the effect of genotype 1 HCV infection on hepatic lipotoxicity and lipid metabolism. Cellular lipid accumulation was induced in Huh-7 hepatoma cells transfected with HCV genotype 1b replicon (HCV+) by incubation with increasing doses of palmitic acid (C16:0) or oleic acid (C18:1 n-9) complexed to albumin mimicking hyperlipidemic conditions. Mock transfected hepatoma cells (HCV-) were used as controls. Incubation with oleic acid concentrations as high as 0.5 mM did not induce toxic effects in HCV+ or HCV- cells. In contrast, incubation with palmitic acid caused dose-dependently cytotoxic effects which were more pronounced in HCV+ compared to HCV- cells. Further analysis with subtoxic palmitic and oleic acid concentrations revealed a higher uptake of fatty acids and intracellular triglyceride accumulation in HCV+ compared to HCV- cells. Carnitine palmitoyltransferase I (CPT1) expression, indicative of mitochondrial beta-oxidation, was markedly stimulated by lipid exposure in HCV+ but not in HCV- cells. Furthermore, heme oxygenase 1 (HMOX1) expression levels increased in FA stimulated cells, and this increase was significantly higher in HCV+ compared to HCV- cells. In contrast, expression of the key enzymes of hepatic de novo lipogenesis fatty acid synthase (FASN) and stearoyl-CoA desaturase (SCD-1) was significantly reduced upon oleate exposure in HCV- but not in HCV+ cells.
   In summary, our newly developed cell culture model revealed effects of HCV genotype 1b infection on metabolic susceptibility to lipid accumulation and toxicity particularly to saturated lipids. These results may indicate that HCV (genotype 1b) infected individuals with hyperlipidemia may benefit from dietary or pharmacological intervention.
C1 [Koletzko, Leandra] Ludwig Maximilians Univ Munchen, Univ Hosp, Dept Med 2, Munich, Germany.
   [Koletzko, Leandra; Hellerbrand, Claus] Univ Hosp Regensburg, Dept Internal Med 1, Regensburg, Germany.
   [Mahli, Abdo; Hellerbrand, Claus] Friedrich Alexander Univ Erlangen Nurnberg, Emil Fischer Zentrum, Inst Biochem, D-91054 Erlangen, Germany.
C3 University of Munich; University of Regensburg; University of Erlangen
   Nuremberg
RP Hellerbrand, C (corresponding author), Friedrich Alexander Univ Erlangen Nurnberg, Emil Fischer Zentrum, Inst Biochem, D-91054 Erlangen, Germany.
EM claus.hellerbrand@fau.de
RI Mahli, Abdo/AAD-4744-2019
OI Mahli, Abdo/0000-0002-8333-7551
FU German Research Association (DFG) [FOR2127, KFO262]; Interdisciplinary
   Center for Clinical Research Erlangen (IZKF)
FX This study was supported by grants from the German Research Association
   (DFG) (FOR2127 and KFO262) and the Interdisciplinary Center for Clinical
   Research Erlangen (IZKF) to C.H.
CR Adinolfi LE, 2016, INT J MOL SCI, V17, DOI 10.3390/ijms17060803
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NR 29
TC 3
Z9 4
U1 1
U2 8
PU ELSEVIER GMBH
PI MUNICH
PA HACKERBRUCKE 6, 80335 MUNICH, GERMANY
SN 0344-0338
EI 1618-0631
J9 PATHOL RES PRACT
JI Pathol. Res. Pract.
PD OCT
PY 2018
VL 214
IS 10
BP 1700
EP 1706
DI 10.1016/j.prp.2018.08.013
PG 7
WC Pathology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pathology
GA GY0SD
UT WOS:000448231000027
PM 30201523
DA 2025-06-11
ER

PT J
AU Garbarino, S
   Scoditti, E
   Lanteri, P
   Conte, L
   Magnavita, N
   Toraldo, DM
AF Garbarino, Sergio
   Scoditti, Egeria
   Lanteri, Paola
   Conte, Luana
   Magnavita, Nicola
   Toraldo, Domenico M.
TI Obstructive Sleep Apnea With or Without Excessive Daytime Sleepiness:
   Clinical and Experimental Data-Driven Phenotyping
SO FRONTIERS IN NEUROLOGY
LA English
DT Article
DE continuous positive airway pressure; excessive daytime sleepiness;
   hypoxia; obstructive sleep apnea; phenotype; sleep
ID POSITIVE AIRWAY PRESSURE; OXIDATIVE STRESS MARKERS; QUALITY-OF-LIFE;
   INTERMITTENT HYPOXIA; BLOOD-PRESSURE; CARDIOVASCULAR EVENTS;
   GLUCOSE-METABOLISM; INSULIN-RESISTANCE; EPIGENETIC REGULATION;
   ENDOTHELIAL FUNCTION
AB Introduction: Obstructive sleep apnea (OSA) is a serious and prevalent medical condition with major consequences for health and safety. Excessive daytime sleepiness (EDS) is a common-but not universal- accompanying symptom. The purpose of this literature analysis is to understand whether the presence/absence of EDS is associated with different physiopathologic, prognostic, and therapeutic outcomes in OSA patients.
   Methods: Articles in English published in PubMed, Medline, and EMBASE between January 2000 and June 2017, focusing on no-EDS OSA patients, were critically reviewed.
   Results: A relevant percentage of OSA patients do not complain of EDS. EDS is a significant and independent predictor of incident cardiovascular disease (CVD) and is associated with all-cause mortality and an increased risk of metabolic syndrome and diabetes. Male gender, younger age, high body mass index, are predictors of EDS. The positive effects of nasal continuous positive airway pressure (CPAP) therapy on blood pressure, insulin resistance, fatal and non-fatal CVD, and endothelial dysfunction risk factors have been demonstrated in EDS-OSA patients, but results are inconsistent in no-EDS patients. The most sustainable cause of EDS is nocturnal hypoxemia and alterations of sleep architecture, including sleep fragmentation. These changes are less evident in no-EDS patients that seem less susceptible to the cortical effects of apneas.
   Conclusions: There is no consensus if we should consider OSA as a single disease with different phenotypes with or without EDS, or if there are different diseases with different genetic/epigenetic determinants, pathogenic mechanisms, prognosis, and treatment.The small number of studies focused on this issue indicates the need for further research in this area. Clinicians must carefully assess the presence or absence of EDS and decide accordingly the treatment. This approach could improve combination therapy targeted to a patient's specific pathology to enhance both efficacy and long-term adherence to OSA treatment and significantly reduce the social, economic, and health negative impact of OSA.
C1 [Garbarino, Sergio] Univ Genoa, Dept Neurosci Rehabil Ophthalmol Genet & Maternal, Genoa, Italy.
   [Garbarino, Sergio] Univ Genoa, Dept Hlth Sci, Genoa, Italy.
   [Scoditti, Egeria] Natl Res Council CNR, Inst Clin Physiol, Lecce, Italy.
   [Lanteri, Paola] G Gaslini Inst Children, Dept Neurol Sci, Genoa, Italy.
   [Conte, Luana] V Fazzi Univ Hosp, ASL Lecce, Interdisciplinary Lab Appl Res Med DReAM, Lecce, Italy.
   [Conte, Luana] Univ Salento, Dept Biol & Environm Sci & Technol, Lecce, Italy.
   [Magnavita, Nicola] Univ Cattolica Sacro Cuore, Inst Publ Hlth, Rome, Italy.
   [Toraldo, Domenico M.] V Fazzi Hosp, ASL Lecce, Cardioresp Care Unit, Rehabil Dept, Lecce, Italy.
C3 University of Genoa; University of Genoa; Consiglio Nazionale delle
   Ricerche (CNR); Istituto di Fisiologia Clinica (IFC-CNR); University of
   Genoa; IRCCS Istituto Giannina Gaslini; University of Salento; Catholic
   University of the Sacred Heart; IRCCS Policlinico Gemelli
RP Scoditti, E (corresponding author), Natl Res Council CNR, Inst Clin Physiol, Lecce, Italy.
EM egeria.scoditti@ifc.cnr.it
RI Magnavita, Nicola/J-6074-2014; Conte, Luana/AAC-1966-2019; Lanteri,
   Paola/T-8544-2019; SCODITTI, EGERIA/J-8609-2016; Garbarino,
   Sergio/X-5368-2018
OI Lanteri, Paola/0000-0001-7561-7724; SCODITTI,
   EGERIA/0000-0003-2753-8487; Garbarino, Sergio/0000-0002-8508-552X;
   Conte, Luana/0000-0002-8741-3478; TORALDO, Domenico
   Maurizio/0000-0003-0023-0212
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NR 162
TC 73
Z9 76
U1 2
U2 9
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2295
J9 FRONT NEUROL
JI Front. Neurol.
PD JUN 27
PY 2018
VL 9
AR 505
DI 10.3389/fneur.2018.00505
PG 17
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA GK9RR
UT WOS:000436590600001
PM 29997573
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Tola, EN
   Yalcin, SE
   Dugan, N
AF Tola, Esra Nur
   Yalcin, Serenat Eris
   Dugan, Nadiye
TI The predictive effect of inflammatory markers and lipid accumulation
   product index on clinical symptoms associated with polycystic ovary
   syndrome in nonobese adolescents and younger aged women
SO EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
LA English
DT Article
DE Inflammatory markers; Adolescent; Polycystic ovary syndrome; Insulin
   resistance; Cardiovascular disease
ID INCREASED OXIDATIVE STRESS; GRADE CHRONIC INFLAMMATION; CARDIOVASCULAR
   RISK; INSULIN-RESISTANCE; METABOLIC SYNDROME; NEOPTERIN; PREVALENCE;
   ABNORMALITIES; POPULATION
AB Objective(s): The aim of our study is to analyse the inflammatory markers and lipid accumulation product (LAP) index in nonobese adolescents and younger aged women with polycystic ovary syndrome (PCOS) compared with age and body mass index (BMI)-matched healthy controls and to determine whether the investigated parameters are potential markers for the etiopathogenesis of PCOS. We also aim to determine whether these inflammatory markers are predictive for developing some clinical implications, such as cardiovascular disease (CVD) and insulin resistance (IR), associated with PCOS.
   Study design: A total of 34 adolescents and younger aged females with PCOS, and 33 age and BMI-matched healthy controls were recruited for our study. All participants were nonobese (BMI < 25). Neopterin (NEO), C-reactive protein (CRP) levels and complete blood parameters were assessed. LAP index and homeostasis model assessment of IR (HOMA-IR) were calculated; anthropometric, clinical and biochemical parameters were also recorded.
   Results: Serum NEO, CRP levels and LAP index were significantly increased in nonobese adolescents and younger aged females with PCOS compared to healthy controls. We could not found any predictive effect of investigated inflammatory markers and LAP index on CVD risk among PCOS patients after adjustment for abdominal obesity. We also found a positive predictive effect of WBC and a negative predictive effect of lymphocytes on IR in PCOS patients after adjustment for abdominal obesity. We did not find any predictor effect of NEO on IR, but it was a positive predictive marker for an elevated HOMA-IR index.
   Conclusion(s): Elevated NEO, CRP levels and LAP index could have potential roles in the etiopathogenesis of PCOS in nonobese adolescents and younger aged females,NEO could be a predictive marker for elevated HOMA-IR index, and WBC and lymphocytes could be predictive for the development of IR among nonobese adolescents and younger aged females with PCOS. (C) 2017 Elsevier B.V. All rights reserved.
C1 [Tola, Esra Nur; Yalcin, Serenat Eris] Suleyman Demirel Univ, Dept Obstet & Gynecol, Fac Med, Isparta, Turkey.
   [Dugan, Nadiye] Kanuni Sultan Suleyman Training & Res Hosp, Dept Obstet & Gynecol, Istanbul, Turkey.
C3 Suleyman Demirel University; Istanbul Kanuni Sultan Suleyman Training &
   Research Hospital
RP Tola, EN (corresponding author), Suleyman Demirel Univ, Dept Obstet & Gynecol, Fac Med, Isparta, Turkey.
EM perinatalog@hotmail.com; serenateris@hotmail.com;
   nadiye_dugan@hotmail.com
RI Yalcin, Serenat/I-5055-2019
OI Eris Yalcin, Serenat/0000-0002-6465-325X
CR Agacayak E, 2015, MED SCI MONITOR, V21, P2446, DOI 10.12659/MSM.894368
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NR 31
TC 26
Z9 27
U1 0
U2 12
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0301-2115
EI 1872-7654
J9 EUR J OBSTET GYN R B
JI Eur. J. Obstet. Gynecol. Reprod. Biol.
PD JUL
PY 2017
VL 214
BP 168
EP 172
DI 10.1016/j.ejogrb.2017.05.014
PG 5
WC Obstetrics & Gynecology; Reproductive Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology; Reproductive Biology
GA EZ4QK
UT WOS:000404697400026
PM 28535403
DA 2025-06-11
ER

PT J
AU Wang, HH
   Xiang, GD
AF Wang, Hao-hua
   Xiang, Guang-da
TI Changes of plasma concentration of osteoprotegerin and its association
   with endothelial dysfunction before and after hypouricemic therapy in
   patients with hyperuricemia
SO MODERN RHEUMATOLOGY
LA English
DT Article
DE Endothelial function; Hyperuricemia; Osteoprotegerin; Serum uric acid
ID CORONARY-ARTERY-DISEASE; CHRONIC KIDNEY-DISEASE; URIC-ACID; OXIDATIVE
   STRESS; SERUM OSTEOPROTEGERIN; VASCULAR CALCIFICATION; METABOLIC
   SYNDROME; ATHEROSCLEROSIS; INFLAMMATION; RISK
AB Objective. Osteoprotegerin (OPG) is a secreted glycoprotein in the regulation of bone turnover. Recently, many studies showed that OPG acts as an important regulatory molecule in the vascular systems. Our objective was to examine the plasma OPG levels alteration and its association with endothelial function before and after hypouricemic therapy in patients with hyperuricemia.
   Methods. Thirty patients (28 males and 2 females, serum uric acid > 7.0 mg/dl) with hyperuricemia were selected. Thirty healthy individuals (28 males and 2 females) with normal serum uric acid were also selected as control. Patients were administered with hypouricemic therapy for 6 months. Plasma OPG concentration was measured in duplicate using a sandwich ELISA and high-resolution ultrasound was used to measure brachial artery diameter at rest, after reactive hyperemia and after sublingual glyceryltrinitrate.
   Results. Plasma OPG levels in patients with hyperuricemia before hypouricemic therapy was significantly higher than those in controls (3.39 +/- 0.25 vs. 2.05 +/- 0.74 ng/L, p < 0.01). After hypouricemic therapy, OPG levels decreased markedly (2.54 +/- 0.38 ng/L, p < 0.01). Flow-mediated dilation (FMD) in patients with hyperuricemia was 3.07 +/- 1. 23%, which was significantly lower than that in control subjects (4.62 +/- 0.69%, p < 0.01), and it improved significantly after hypouricemic therapy (3.91 +/- 1.37%, p < 0.01). The absolute changes in OPG showed a significant positive correlation with the changes in serum uric acid (p < 0.05) and negative correlation with the changes in FMD (p < 0.01) in patients with hyperuricemia during the course of hypouricemic therapy.
   Conclusion. The current study demonstrates that plasma OPG levels increased significantly in patients with hyperuricemia and decreased significantly after hypouricemic therapy, and are correlated with FMD. These findings support the growing concept that elevated plasma OPG levels may be involved with the development of endothelial dysfunction in patients with hyperuricemia.
C1 [Wang, Hao-hua] Dongguan Peoples Hosp, Dept Endocrinol, Dongguan 523000, Guangdong Provi, Peoples R China.
   [Xiang, Guang-da] Guangzhou Command, Wuhan Gen Hosp, Dept Endocrinol, Wuhan, Hubei Province, Peoples R China.
RP Wang, HH (corresponding author), Dongguan Peoples Hosp, Dept Endocrinol, Wandao Rd 3, Dongguan 523000, Guangdong Provi, Peoples R China.
EM hello_vanwang@sina.com
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NR 39
TC 9
Z9 9
U1 0
U2 10
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1439-7595
EI 1439-7609
J9 MOD RHEUMATOL
JI Mod. Rheumatol.
PD JAN
PY 2015
VL 25
IS 1
BP 123
EP 127
DI 10.3109/14397595.2014.926852
PG 5
WC Rheumatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Rheumatology
GA AX1XF
UT WOS:000346736400020
PM 24947824
DA 2025-06-11
ER

PT J
AU He, LY
   Zhao, JF
   Han, JL
   Shen, SS
   Chen, XJ
AF He, Li-Yun
   Zhao, Jun-Feng
   Han, Jiang-Li
   Shen, Shan-Shan
   Chen, Xu-Jiao
TI Correlation between serum free fatty acids levels and Gensini score in
   elderly patients with coronary heart disease
SO JOURNAL OF GERIATRIC CARDIOLOGY
LA English
DT Article
DE Coronary heart disease; Free fatty acids; Gensini score; The elderly
ID TUMOR-NECROSIS-FACTOR; ARTERY-DISEASE; ENDOTHELIAL DYSFUNCTION;
   STIMULATES LIPOLYSIS; METABOLIC SYNDROME; OXIDATIVE STRESS;
   ATHEROSCLEROSIS; SEVERITY; CELLS; HOMOCYSTEINE
AB Objectives To investigate the relationship between serum free fatty acids (FFAs) levels and the severity of coronary artery lesions in elderly patients with coronary heart disease (CAD).
   Methods A total of 172 elderly patients who underwent coronary angiography were divided into CAD group (n = 128) and non-CAD group (n = 44) according to the results of coronary angiography. Serum FFAs and lipid levels were measured and the Gensini score were calculated.
   Results No matter the differences between age, gender and the usage of statins or not, there was no statistical significance in FFAs levels (P > 0.05). In terms of the Gensini score, it was higher in patients aged 70-79 years than in patients 60-69 years old [ 15.00 (5.00, 34.00) vs. 10.00 (2.00, 24.00), P < 0.05], higher in men than women [ 14.00 (4.00, 34.00) vs. 7.00 (2.50, 19.75), P < 0.05], and higher in patients on statins [ 13.50 (4.25, 33.50) vs. 6.50 (2.00, 18.00), P < 0.05]. The serum FFAs levels [ 449.50 (299.00, 624.75) mEq/L vs. 388.00 (258.50, 495.25) mEq/L, P < 0.05] and Gensini score [ 17.50 (8.00, 41.75) vs. 1.00 (0, 5.00), P < 0.05] were higher in the CAD group than in the non-CAD group. In the CAD group, there was no statistical significance in FFAs levels among patients with different numbers of diseased coronary vessels (P > 0.05). Furthermore, the FFAs levels were positively correlated with the Gensini score (r = 0.394, P = 0.005). Regression analysis showed that the FFAs levels were related to the Gensini score independently after adjusting for the other risk factors.
   Conclusions The serum FFAs levels were associated with the Gensini score in elderly patients with CAD. It might indicate FFAs as a biomarker predicting the severity of coronary artery lesions.
C1 [He, Li-Yun; Han, Jiang-Li] Peking Univ, Hosp 3, Dept Cardiol, Beijing 100191, Peoples R China.
   [He, Li-Yun; Han, Jiang-Li] Minist Hlth, Key Lab Cardiovasc Mol Biol & Regulatory Peptides, Beijing 100191, Peoples R China.
   [Zhao, Jun-Feng] Zhejiang Chinese Med Univ, Affiliated Hosp 3, Dept Emergency, Hangzhou 310005, Zhejiang, Peoples R China.
   [Shen, Shan-Shan; Chen, Xu-Jiao] Zhejiang Hosp, Dept Geriatr, Hangzhou 310013, Zhejiang, Peoples R China.
C3 Peking University; Zhejiang Chinese Medical University
RP Chen, XJ (corresponding author), Zhejiang Hosp, Dept Geriatr, Hangzhou 310013, Zhejiang, Peoples R China.
EM lily197459@163.com
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   Yu J, 2013, J GERIATR CARDIOL, V10, P159, DOI 10.3969/j.issn.1671-5411.2013.02.007
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NR 35
TC 11
Z9 16
U1 0
U2 18
PU SCIENCE PRESS
PI BEIJING
PA 16 DONGHUANGCHENGGEN NORTH ST, BEIJING 100717, PEOPLES R CHINA
SN 1671-5411
J9 J GERIATR CARDIOL
JI J. Geriatr. Cardiol.
PY 2014
VL 11
IS 1
BP 57
EP 62
DI 10.3969/j.issn.1671-5411.2014.01.003
PG 6
WC Cardiac & Cardiovascular Systems; Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Geriatrics & Gerontology
GA AE6DE
UT WOS:000334078700009
PM 24748883
DA 2025-06-11
ER

PT J
AU Dullaart, RPF
   Annema, W
   de Boer, JF
   Tietge, UJF
AF Dullaart, Robin P. F.
   Annema, Wijtske
   de Boer, Jan Freark
   Tietge, Uwe J. F.
TI Pancreatic β-cell function relates positively to HDL functionality in
   well-controlled Type 2 diabetes mellitus
SO ATHEROSCLEROSIS
LA English
DT Article
DE beta-Cell function; Cholesterol efflux; High density lipoproteins; HDL
   antioxidative function; Cellular cholesterol efflux; Homeostasis model
   assessment; Insulin sensitivity; Type 2 diabetes mellitus
ID DENSITY-LIPOPROTEIN PARTICLES; ELEVATED OXIDATIVE STRESS; CHOLESTEROL
   EFFLUX; INSULIN-RESISTANCE; METABOLIC SYNDROME; GLUCOSE; PLASMA; ABCA1;
   HOMEOSTASIS; RISK
AB Background: High density lipoproteins (HDLs) have been implicated in glucose homeostasis. Among subjects with normal fasting glucose (NFG), impaired fasting glucose (IFG) and Type 2 diabetes mellitus (T2DM) we tested whether pancreatic beta-cell function relates to HDL functionality, as determined by HDL anti-oxidative capacity and cellular cholesterol efflux to plasma.
   Subjects and methods: HDL anti-oxidative capacity (inhibition of LDL oxidation in vitro), cellular cholesterol efflux (the ability of plasma to stimulate cholesterol efflux out of cultured fibroblasts obtained from a single human donor), glucose and insulin were determined in fasting plasma samples from 37 subjects with NFG, 36 with IFG and 22 with T2DM (no glucose lowering drug or insulin treatment; HbA1c 6.0 +/- 1.0%). Homeostasis model assessment was used to estimate pancreatic beta-cell function (HOMA-beta) and insulin resistance (HOMAir).
   Results: HOMA-beta was lowest, whereas HOMAir was highest in T2DM (P<0.01 and P<0.001 vs. NFG). HDL anti-oxidative capacity and cellular cholesterol efflux did not differ significantly according to glucose tolerance category. In univariate analysis and after controlling for HOMAir both HDL anti-oxidative capacity (P<0.05) and cellular cholesterol efflux (P<0.01) were positively correlated with HOMA-beta in T2DM, but not in NFG and IFG. In age-, sex-and HOMAir-adjusted analyses, T2DM status interacted positively with HDL anti-oxidative capacity (P = 0.001) and cellular cholesterol efflux (P = 0.042) on HOMA-beta. HbA1c interacted similarly with HDL functionality measures on HOMA-beta.
   Conclusions: Pancreatic beta-cell function relates to pathophysiologically relevant measures of HDL function in T2DM, but not in NFG and IFG. Better HDL functionality may contribute to maintenance of beta-cell function in subjects with well-controlled T2DM. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
C1 [Dullaart, Robin P. F.] Univ Med Ctr Groningen, Dept Endocrinol, Ctr Liver Digest & Metab Dis, NL-9700 RB Groningen, Netherlands.
   [Dullaart, Robin P. F.; Annema, Wijtske; de Boer, Jan Freark; Tietge, Uwe J. F.] Univ Groningen, Groningen, Netherlands.
   [Annema, Wijtske; Tietge, Uwe J. F.] Univ Med Ctr Groningen, Dept Pediat, Ctr Liver Digest & Metab Dis, NL-9700 RB Groningen, Netherlands.
   [Annema, Wijtske; Tietge, Uwe J. F.] Top Insititute Food & Nutr, Wageningen, Netherlands.
C3 University of Groningen; University of Groningen; University of
   Groningen; Top Institute Food & Nutrition
RP Dullaart, RPF (corresponding author), Univ Med Ctr Groningen, Dept Endocrinol, Ctr Liver Digest & Metab Dis, POB 30001, NL-9700 RB Groningen, Netherlands.
EM r.p.f.dullaart@int.umcg.nl
FU Dutch Diabetes Research Foundation [2001.00.012]; Top Institute (TI)
   Food and Nutrition; Groningen Expert Center for Kids with Obesity
FX R.P.F. Dullaart, MD, PhD, is supported by a grant from the Dutch
   Diabetes Research Foundation, grant 2001.00.012. U.J.F. Tietge, MD, PhD,
   is supported by grants from the Top Institute (TI) Food and Nutrition
   and the Groningen Expert Center for Kids with Obesity. LD Dikkeschei,
   PhD, Laboratory of Clinical Chemistry, Isala Clinics, Zwolle, The
   Netherlands, performed the lipid and apolipoprotein assays. A.K. Groen,
   PhD, Department of Pediatrics, Center for Liver, Digestive and Metabolic
   Diseases, University Medical Center Groningen, The Netherlands, carried
   out the cellular cholesterol efflux assays. The help of R. de Vries, MD,
   PhD, in data collection is greatly appreciated. We gratefully
   acknowledge the statistical advice of J.L. Hillege, MD, PhD, Department
   of Cardiology, and of W.J. Sluiter, PhD, Department of Endodrinology,
   University Medical Center Groningen, The Netherlands.
CR Abderrahmani A, 2007, DIABETOLOGIA, V50, P1304, DOI 10.1007/s00125-007-0642-z
   [Anonymous], 2006, Definition and diagnosis of diabetes mellitus and intermediate hyperglycaemia: Report of a WHO/IDF consultation
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NR 30
TC 39
Z9 39
U1 0
U2 8
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0021-9150
EI 1879-1484
J9 ATHEROSCLEROSIS
JI Atherosclerosis
PD JUN
PY 2012
VL 222
IS 2
BP 567
EP 573
DI 10.1016/j.atherosclerosis.2012.03.037
PG 7
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 947OJ
UT WOS:000304439000043
PM 22541874
DA 2025-06-11
ER

PT J
AU Corona, G
   Rastrelli, G
   Forti, G
   Maggi, M
AF Corona, Giovanni
   Rastrelli, Giulia
   Forti, Gianni
   Maggi, Mario
TI Update in Testosterone Therapy for Men (CME)
SO JOURNAL OF SEXUAL MEDICINE
LA English
DT Article
DE Male Hypogonadism; Testosterone; Testosterone Replacement Therapy
ID PLACEBO-CONTROLLED TRIALS; ENDOGENOUS SEX-HORMONES; LATE-ONSET
   HYPOGONADISM; MIDDLE-AGED MEN; BONE-MINERAL DENSITY; OLDER MEN; ERECTILE
   DYSFUNCTION; METABOLIC SYNDROME; ANDROGEN DEFICIENCY; CARDIOVASCULAR
   RISK
AB Introduction.
   Male hypogonadism is a condition characterized by inadequate testicular production of sex steroids and sperms; however, the term is more commonly used to identify testosterone (T) deficiency. When fertility is not desired, T replacement therapy (TRT) is the gold standard.
   Aim.
   To review the pathogenesis of male hypogonadism and the available preparations for TRT, along with the main clinical outcomes.
   Methods.
   A systematic search of published evidence was performed using Medline (1969 to September 2010). Data from a consecutive series of subjects attending our Andrology Unit were also provided to stress the clinical correlates of low T. Inventories available for detecting hypogonadism (including ANDROTEST) were overviewed.
   Main Outcome Measures.
   The most important studies regarding the pathogenesis of male hypogonadism and the preparations for its treatment were reviewed. To review TRT outcomes, only meta-analytic studies were considered.
   Results.
   The goals of TRT are to alleviate clinical symptoms and to restore serum T levels to the mid-normal range, without significant side effects or safety concerns. Different T formulations have been approved. TRT is associated with a reduction of fat mass, an increase of lean mass, and a possible positive effect on lipid profile and glycometabolic control. Bone density and depressive symptoms are improved by TRT, while effects on cardiovascular risk and frailty are more controversial. No increase of prostate cancer and prostate-related problems has been reported so far. TRT, alone or in combination with phosphodiesterase type 5 inhibitors, is considered the first-line therapy in hypogonadal subjects with erectile dysfunction.
   Conclusions.
   T deficiency is highly prevalent in the aging male and represents a sign of physical and sexual frailty. The significance of low T in elderly men has yet to be completely clarified. Large, prospective intervention trials will help solve this dilemma. Corona G, Rastrelli G, Forti G, and Maggi M. Update in testosterone therapy for men. J Sex Med 2011;8:639-654.
C1 [Corona, Giovanni; Rastrelli, Giulia; Forti, Gianni; Maggi, Mario] Univ Florence, Androl & Sexual Med Unit, Dept Clin Physiopathol, I-50139 Florence, Italy.
   [Corona, Giovanni] Maggiore Bellaria Hosp, Dept Med, Endocrinol Unit, Bologna, Italy.
C3 University of Florence; AUSL di Bologna
RP Maggi, M (corresponding author), Univ Florence, Androl & Sexual Med Unit, Dept Clin Physiopathol, Viale Pieraccini 6, I-50139 Florence, Italy.
EM m.maggi@dfc.unifi.it
RI Maggi, Mario/AAB-8284-2019
OI Rastrelli, Giulia/0000-0002-6164-4278; MAGGI, Mario/0000-0003-3267-4221
CR [Anonymous], BEST PRACT IN PRESS
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   MORGANS ANAL REPORT
NR 66
TC 71
Z9 79
U1 0
U2 7
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1743-6095
EI 1743-6109
J9 J SEX MED
JI J. Sex. Med.
PD MAR
PY 2011
VL 8
IS 3
BP 639
EP 654
DI 10.1111/j.1743-6109.2010.02200.x
PG 16
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 726EX
UT WOS:000287703100002
PM 21711483
DA 2025-06-11
ER

PT J
AU Roelofsen, H
   Dijkstra, M
   Weening, D
   de Vries, MP
   Hoek, A
   Vonk, RJ
AF Roelofsen, Han
   Dijkstra, Martijn
   Weening, Desiree
   de Vries, Marcel P.
   Hoek, Annemieke
   Vonk, Roel J.
TI Comparison of Isotope-labeled Amino Acid Incorporation Rates (CILAIR)
   Provides a Quantitative Method to Study Tissue Secretomes
SO MOLECULAR & CELLULAR PROTEOMICS
LA English
DT Article
ID ADIPOSE-TISSUE; ENDOCRINE ORGAN; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   CELL-CULTURE; INFLAMMATION; ADIPOCYTE; OBESITY; FAT; DIFFERENTIATION
AB Adipose tissue is an endocrine organ involved in regulation of whole-body energy metabolism via storage of lipids and secretion of various peptide hormones (adipokines). We previously characterized the adipose tissue secretome and showed that [(13)C]lysine incorporation into secreted proteins can be used to determine the origin of identified proteins. In the present study we determined the effect of insulin on the secretome by comparing incorporation rates of (13)C-labeled lysine in the presence and absence of insulin. Human visceral adipose tissue from one patient was divided over six dishes. After subsequent washes to remove serum proteins, [(13)C]lysinecontaining medium was added. Three dishes also received 60 nm insulin. The other three were controls. After 72 h of culture, media were collected and processed separately, involving concentration by ultrafiltration and fractionation by SDS-PAGE followed by in-gel digestion of excised bands and LC-MS/MS analyses. The obtained spectra were used for database searching and calculation of heavy/light ratios. The three control data sets shared 342 proteins of which 156 were potentially secreted and contained label. The three insulin-derived data sets shared 361 proteins of which 141 were potentially secreted and contained label. After discarding secreted proteins with very low label incorporation, 121 and 113 proteins remained for control and insulin data sets, respectively. The average coefficient of variation for control triplicates was 10.0% and for insulin triplicates was 18.3%. By comparing heavy/light ratios in the absence and presence of insulin we found 24 up-regulated proteins and four down-regulated proteins, and 58 proteins showed no change. Proteins involved in the endoplasmic reticulum stress response and in extracellular matrix remodeling were up-regulated by insulin. In conclusion, comparison of isotope-labeled amino acid incorporation rates (CILAIR) allows quantitative assessment of changes in protein secretion without the need for 100% label incorporation, which cannot be reached in differentiated tissues or cells. Molecular & Cellular Proteomics 8:316-324, 2009.
C1 [Roelofsen, Han] Univ Groningen, Univ Med Ctr Groningen, Ctr Med Biom, NL-9713 AV Groningen, Netherlands.
   [Hoek, Annemieke] Univ Groningen, Univ Med Ctr Groningen, Dept Obstet & Gynecol, NL-9713 AV Groningen, Netherlands.
C3 University of Groningen; University of Groningen
RP Roelofsen, H (corresponding author), Univ Groningen, Univ Med Ctr Groningen, Ctr Med Biom, Antonius Deusinglaan 1, NL-9713 AV Groningen, Netherlands.
EM j.roelofsen@med.umcg.nl
FU Netherlands Proteomic Centre [6.3]
FX This work was supported by the Netherlands Proteomic Centre (Project
   6.3). The costs of publication of this article were defrayed in part by
   the payment of page charges. This article must therefore be hereby
   marked "advertisement" in accordance with 18 U. S. C. Section 1734
   solely to indicate this fact.
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NR 23
TC 38
Z9 41
U1 0
U2 3
PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3996 USA
SN 1535-9476
J9 MOL CELL PROTEOMICS
JI Mol. Cell. Proteomics
PD FEB
PY 2009
VL 8
IS 2
BP 316
EP 324
DI 10.1074/mcp.M800254-MCP200
PG 9
WC Biochemical Research Methods
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 406BP
UT WOS:000263270300009
PM 18840871
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Sternau, M
   Czajkowski, M
   Wierzbicki, P
   Kogut-Wierzbicka, M
   Zarzyka, K
   Milewczyk, M
   Czurak, K
   Proczko-Stepaniak, M
   Matuszewski, M
AF Sternau, Magdalena
   Czajkowski, Mateusz
   Wierzbicki, Piotr
   Kogut-Wierzbicka, Marzena
   Zarzyka, Karolina
   Milewczyk, Maciej
   Czurak, Krzysztof
   Proczko-Stepaniak, Monika
   Matuszewski, Marcin
TI Bariatric Surgery Has a Long-Term Beneficial Impact on Urinary
   Incontinence in Women with Obesity
SO MEDICINA-LITHUANIA
LA English
DT Article
DE urinary incontinence; bariatric surgery; obesity; woman with obesity;
   sleeve gastrectomy; gastric bypass
ID MIDURETHRAL SLING PROCEDURES; OVERACTIVE BLADDER; METABOLIC SYNDROME;
   WEIGHT-LOSS; SHORT-FORM; QUESTIONNAIRE; PRESSURE; HEALTH
AB Background and Objectives: To evaluate the long-term efficacy of bariatric surgery in ameliorating urinary incontinence in women with obesity. Additionally, to assess the impact of comorbidities on the persistence of symptoms and compare the effectiveness of two types of bariatric interventions. Materials and Methods: This prospective, single-centre study included 124 women with preoperative urinary incontinence (UI). A total of 92 (74.19%) responded to follow-up and underwent laparoscopic sleeve gastrectomy (LSG) (n = 52; 56.52%) or one anastomosis gastric bypass (OAGB) (n = 40; 43.48%). The cohort was divided into stress urinary incontinence (SUI) (n = 57; 61.96%), mixed urinary incontinence (MUI) (n = 33; 35.87%), and urge urinary incontinence (UUI) (n = 2; 2.17%). Before surgery, patients were assessed for comorbidities and completed the International Consultation on Incontinence Questionnaire-Urinary Incontinence Short Form (ICIQ-UI SF) (score range 0-21) and the Urogenital Distress Inventory (UDI-6) (score range 0-100) questionnaires. After 5 years, the patients completed the same questionnaires again for the final assessment. Results: Bariatric surgery demonstrated a statistically significant reduction in UI symptoms (p < 0.001), with a more pronounced improvement in SUI than in MUI, and with complete resolution in patients experiencing UUI. LSG was more effective than OAGB at alleviating UI (p < 0.001 vs. p = 0.017). Notably, childbirth, particularly vaginal delivery, was associated with a higher risk of persistent UI after surgery (p = 0.025). The correlation between postoperative BMI and improvement in UI symptoms was not statistically significant (p = 0.64). Conclusions: Bariatric surgery provides a beneficial secondary effect on urinary incontinence (UI) in women with obesity who undergo the procedure for obesity. The LSG method is superior to OAGB when considering the improvement in incontinence symptoms. Furthermore, the LSG procedure should be considered the primary choice for women with obesity experiencing UI with a history of vaginal delivery.
C1 [Sternau, Magdalena; Czajkowski, Mateusz; Czurak, Krzysztof; Matuszewski, Marcin] Med Univ Gdansk, Dept Urol, PL-80210 Gdansk, Poland.
   [Wierzbicki, Piotr] Med Univ Gdansk, Dept Histol, PL-80210 Gdansk, Poland.
   [Kogut-Wierzbicka, Marzena] Acad Appl Med & Sci, Fac Med, PL-82300 Elblag, Poland.
   [Zarzyka, Karolina] F Ceynowa Specialist Hosp, Dept Urol, PL-84200 Wejherowo, Poland.
   [Milewczyk, Maciej] Specialist Hosp Koscierzyna, Dept Urol & Oncol Urol, PL-83400 Koscierzyna, Poland.
   [Proczko-Stepaniak, Monika] Med Univ Gdansk, Dept Gen Endocrine & Transplant Surg, PL-80210 Gdansk, Poland.
C3 Fahrenheit Universities; Medical University Gdansk; Fahrenheit
   Universities; Medical University Gdansk; Fahrenheit Universities;
   Medical University Gdansk
RP Sternau, M (corresponding author), Med Univ Gdansk, Dept Urol, PL-80210 Gdansk, Poland.
EM msternau@gumed.edu.pl; mateusz.czajkowski@gumed.edu.pl;
   pwierzb@gumed.edu.pl; m.kogut-wierzbicka@amisns.edu.pl;
   lozycakarolina@gmail.com; maciej.milewczyk@gumed.edu.pl;
   krzysztof.czurak@gumed.edu.pl; mproczko@gumed.edu.pl;
   marcin.matuszewski@gumed.edu.pl
RI Czajkowski, Mateusz/Y-6966-2018
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NR 37
TC 0
Z9 0
U1 1
U2 1
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
SN 1010-660X
EI 1648-9144
J9 MEDICINA-LITHUANIA
JI Med. Lith.
PD MAR 22
PY 2025
VL 61
IS 4
AR 564
DI 10.3390/medicina61040564
PG 13
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 1YH2Y
UT WOS:001476525000001
PM 40282855
OA gold
DA 2025-06-11
ER

PT J
AU Madir, A
   Grgurevic, I
   Tsochatzis, EA
   Pinzani, M
AF Madir, Anita
   Grgurevic, Ivica
   Tsochatzis, Emmanuel A.
   Pinzani, Massimo
TI Portal hypertension in patients with nonalcoholic fatty liver disease:
   Current knowledge and challenges
SO WORLD JOURNAL OF GASTROENTEROLOGY
LA English
DT Review
DE Non-alcoholic fatty liver disease; Portal hypertension;
   Mechanotransduction; Endothelial dysfunction; Hepatic venous pressure
   gradient
ID VENOUS-PRESSURE GRADIENT; INCREASED INTRAHEPATIC RESISTANCE; BAVENO VI
   CRITERIA; ENDOTHELIAL DYSFUNCTION; NITRIC-OXIDE; INSULIN-RESISTANCE;
   KUPFFER CELLS; HEPATIC MICROCIRCULATION; STIFFNESS MEASUREMENT;
   MOLECULAR-MECHANISMS
AB Portal hypertension (PH) has traditionally been observed as a consequence of significant fibrosis and cirrhosis in advanced non-alcoholic fatty liver disease (NAFLD). However, recent studies have provided evidence that PH may develop in earlier stages of NAFLD, suggesting that there are additional pathogenetic mechanisms at work in addition to liver fibrosis. The early development of PH in NAFLD is associated with hepatocellular lipid accumulation and ballooning, leading to the compression of liver sinusoids. External compression and intra-luminal obstacles cause mechanical forces such as strain, shear stress and elevated hydrostatic pressure that in turn activate mechanotransduction pathways, resulting in endothelial dysfunction and the development of fibrosis. The spatial distribution of histological and functional changes in the periportal and perisinusoidal areas of the liver lobule are considered responsible for the pre-sinusoidal component of PH in patients with NAFLD. Thus, current diagnostic methods such as hepatic venous pressure gradient (HVPG) measurement tend to underestimate portal pressure (PP) in NAFLD patients, who might decompensate below the HVPG threshold of 10 mmHg, which is traditionally considered the most relevant indicator of clinically significant portal hypertension (CSPH). This creates further challenges in finding a reliable diagnostic method to stratify the prognostic risk in this population of patients. In theory, the measurement of the portal pressure gradient guided by endoscopic ultrasound might overcome the limitations of HVPG measurement by avoiding the influence of the pre-sinusoidal component, but more investigations are needed to test its clinical utility for this indication. Liver and spleen stiffness measurement in combination with platelet count is currently the best-validated non-invasive approach for diagnosing CSPH and varices needing treatment. Lifestyle change remains the cornerstone of the treatment of PH in NAFLD, together with correcting the components of metabolic syndrome, using nonselective beta blockers, whereas emerging candidate drugs require more robust confirmation from clinical trials.
C1 [Madir, Anita; Grgurevic, Ivica] Univ Hosp Dubrava, Dept Gastroenterol Hepatol & Clin Nutr, Zagreb 10000, Croatia.
   [Grgurevic, Ivica] Univ Zagreb, Sch Med, Zagreb 10000, Croatia.
   [Grgurevic, Ivica] Univ Zagreb, Fac Pharm & Biochem, Zagreb 10000, Croatia.
   [Tsochatzis, Emmanuel A.; Pinzani, Massimo] Royal Free Hosp, UCL Inst Liver & Digest Hlth, London NW3 2PF, England.
   [Tsochatzis, Emmanuel A.; Pinzani, Massimo] UCL, London NW3 2PF, England.
   [Grgurevic, Ivica] Univ Hosp Dubrava, Dept Gastroenterol Hepatol & Clin Nutr, Gojko Susak Ave 6, Zagreb 10000, Croatia.
C3 University of Zagreb; University of Zagreb; University of London;
   University College London; UCL Medical School; Royal Free London NHS
   Foundation Trust; University of London; University College London
RP Grgurevic, I (corresponding author), Univ Hosp Dubrava, Dept Gastroenterol Hepatol & Clin Nutr, Gojko Susak Ave 6, Zagreb 10000, Croatia.
EM ivica.grgurevic@mef.hr
RI Grgurevic, Ivica/AFW-2415-2022; Tsochatzis, Emmanuel/A-1651-2012
OI Tsochatzis, Emmanuel/0000-0001-5069-2461
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NR 173
TC 7
Z9 7
U1 2
U2 4
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 7041 Koll Center Parkway, Suite 160, PLEASANTON, CA, UNITED STATES
SN 1007-9327
EI 2219-2840
J9 WORLD J GASTROENTERO
JI World J. Gastroenterol.
PD JAN 28
PY 2024
VL 30
IS 4
DI 10.3748/wjg.v30.i4.290
PG 19
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA HA7R3
UT WOS:001156836000009
PM 38313235
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Kotzakioulafi, E
   Bakaloudi, DR
   Chrysoula, L
   Theodoridis, X
   Antza, C
   Tirodimos, I
   Chourdakis, M
AF Kotzakioulafi, Evangelia
   Bakaloudi, Dimitra Rafailia
   Chrysoula, Lydia
   Theodoridis, Xenophon
   Antza, Christina
   Tirodimos, Ilias
   Chourdakis, Michail
TI High Versus Low Adherence to the Mediterranean Diet for Prevention of
   Diabetes Mellitus Type 2: A Systematic Review and Meta-Analysis
SO METABOLITES
LA English
DT Review
DE diabetes mellitus type 2; healthy eating; dietary pattern; prevention
   Mediterranean diet; adherence
ID CARDIOVASCULAR RISK-FACTORS; IMPAIRED FASTING GLUCOSE;
   MYOCARDIAL-INFARCTION; METABOLIC SYNDROME; OXIDATIVE STRESS; ENDOTHELIAL
   DYSFUNCTION; PLASMA-CONCENTRATIONS; INSULIN-RESISTANCE; QUALITY SCORES;
   STYLE DIET
AB Diabetes mellitus type 2 (DMT-2) presents with a growing incidence, and its complications contribute mainly to cardiovascular disease and overall mortality. DMT-2 prevention and early stage management include lifestyle modification by adopting healthy eating patterns and increasing physical activity levels. The Mediterranean diet (MD) is associated with beneficial effects on human health and has been found effective for preventing and managing DMT-2. The purpose of this meta-analysis is to investigate whether the level of MD adherence plays a role in DMT-2 prevention and to what extent. A systematic literature search in PubMed, EMBASE, Web of Science Core Collection, Scopus, and Google Scholar databases was conducted until November 2022, and related observational studies fulfilling the eligibility criteria were included. The literature search concluded with 24 studies in the qualitative analysis and 23 studies in the quantitative analysis. Of those, 18 cohort studies were eligible for meta-analysis with hazard ratio as effect size and five studies providing odds ratio as effect size. The cohort studies included 248,140 participants with a mean follow-up of 10.8 years (3 to 22 years). Individuals with high adherence to MD presented an 11% and 18% decrease in risk and odds, respectively, of developing DMT-2 compared to those with low MD adherence (HR 0.89, 95%CI 0.83 to 0.95) and (OR 0.82, 95%CI 0.72 to 0.93). In studies where the follow-up was longer than 10 years, the 12% decrease in the risk of developing DMT-2 remained (HR 0.88 95%CI 0.84 to 0.92), whereas in studies where follow-up was less than 10 years, no difference between groups with different levels of adherence was found. Long-term high MD adherence is associated with a reduced risk of developing DMT-2, but further studies are needed to confirm these results.
C1 [Kotzakioulafi, Evangelia; Bakaloudi, Dimitra Rafailia; Chrysoula, Lydia; Theodoridis, Xenophon; Tirodimos, Ilias; Chourdakis, Michail] Aristotle Univ Thessaloniki, Fac Hlth Sci, Sch Med, Lab Hyg Social & Prevent Med & Med Stat, Thessaloniki 54124, Greece.
   [Bakaloudi, Dimitra Rafailia] Univ Washington, Dept Med, Div Med Oncol, Seattle, WA 98195 USA.
   [Antza, Christina] Aristotle Univ Thessaloniki, Papageorgiou Gen Hosp Thessaloniki, Dept Internal Med, Med Sch, Thessaloniki 56403, Greece.
C3 Aristotle University of Thessaloniki; University of Washington;
   University of Washington Seattle; Papageorgiou Hospital; Aristotle
   University of Thessaloniki
RP Chourdakis, M (corresponding author), Aristotle Univ Thessaloniki, Fac Hlth Sci, Sch Med, Lab Hyg Social & Prevent Med & Med Stat, Thessaloniki 54124, Greece.
EM ekotzaki@auth.gr; dbakal@uw.edu; lchrysoula@auth.gr;
   xtheodoridis@auth.gr; kris-antza@hotmail.com; ityrodim@auth.gr;
   mhourd@gapps.auth.gr
RI Kotzakioulafi, Evangelia/AAY-1890-2020; Theodoridis,
   Xenophon/AGS-2767-2022; Antza, Christina/U-6721-2019; Bakaloudi, Dimitra
   Rafailia/GLR-6249-2022
OI Kotzakioulafi, Evangelia/0000-0003-4841-1928; Theodoridis,
   Xenophon/0000-0001-9810-7583; Bakaloudi, Dimitra
   Rafailia/0000-0002-1214-7507; Chourdakis, Michael/0000-0002-9490-8356
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NR 91
TC 7
Z9 7
U1 3
U2 9
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2218-1989
J9 METABOLITES
JI Metabolites
PD JUL
PY 2023
VL 13
IS 7
AR 779
DI 10.3390/metabo13070779
PG 16
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA N4BA6
UT WOS:001036472900001
PM 37512486
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Choi, EH
   Kim, DH
   Ryu, JY
AF Choi, Eui Hyek
   Kim, Dae Hwan
   Ryu, Ji Young
TI The relationship between working hours and the intention to quit smoking
   in male office workers: data from the 7th Korean National Health and
   Nutrition Examination Survey (2016-2017)
SO ANNALS OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
LA English
DT Article
DE Working hours; Intention to quit smoking; Smoking; Office workers; Blue
   collar workers
ID METABOLIC SYNDROME; CESSATION; BEHAVIORS; NICOTINE; RISK
AB Background: The intention to quit smoking is one of the most important factors in smoking cessation. Long working hours is also a constant issue, and many studies have shown an association between the working hours and diseases, including cardiovascular and gastrointestinal diseases. This study evaluated the relationship between working hours and the intention to quit smoking among Korean male office workers, and blue collar workers for comparison.
   Methods: This study was based on the Seventh Korea National Health and Nutrition Examination Survey (2016-2017). A total of 1,389 male workers were smokers, and then office workers and blue collar workers were selected. Logistic regression was used to calculate the odds ratio (OR) for the intention to quit smoking according to smoking-related characteristics and working hours after adjusting for age group, body mass index (kg/m(2)), marital status, household income (quartile), educational level, drinking, exercise, smokingrelated characteristics (smoking initiation age, smoking amount, and attempt to quit smoking more than 1day in the past year) and working hours.
   Results: The percentage of workers who had the intention to quit smoking in 6 months was higher in office workers (38.9% for office workers and 29.4% for blue collars, p = 0.017). Blue collar workers had higher percentages of workers who worked more than 52 hours per week (19.8% for office workers and 38.9% for blue collar workers, p < 0.001). Logistic regression analysis showed that working > 52 hours per week was significantly associated with a lower intention to quit smoking within 6 months among male office workers (OR = 0.30, 95% confidence interval = 0.14-0.66).
   Conclusions: Working more than 52 hours per week was positively related with a lower intention to quit smoking among currently smoking male office workers. Further studies are needed considering more work-related variables such as job stress and physical load.
C1 [Choi, Eui Hyek; Kim, Dae Hwan; Ryu, Ji Young] Inje Univ, Dept Occupat & Environm Med, Haeundae Paik Hosp, 875 Haeundae Ro, Busan 48108, South Korea.
C3 Inje University
RP Ryu, JY (corresponding author), Inje Univ, Dept Occupat & Environm Med, Haeundae Paik Hosp, 875 Haeundae Ro, Busan 48108, South Korea.
EM lyou77@paik.ac.kr
OI Choi, Eui-Hyek/0000-0002-8010-8614
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NR 39
TC 7
Z9 7
U1 0
U2 4
PU KAMJE PRESS, XMLINK, CO
PI SEOUL
PA 101-1601, LOTTE CASTLE PRESIDENT, 109 MAPO-DAERO, SEOUL, MAPO-GU, SOUTH
   KOREA
SN 2052-4374
J9 ANN OCCUP ENVIRON ME
JI Ann. Occup. Environ. Med.
PD MAY 4
PY 2021
VL 33
AR e13
DI 10.35371/aoem.2021.33.e13
PG 11
WC Public, Environmental & Occupational Health
WE Emerging Sources Citation Index (ESCI)
SC Public, Environmental & Occupational Health
GA SM2IC
UT WOS:000657432600001
PM 34754474
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Cornelis, MC
   van Dam, RM
AF Cornelis, Marilyn C.
   van Dam, Rob M.
TI Habitual Coffee and Tea Consumption and Cardiometabolic Biomarkers in
   the UK Biobank: The Role of Beverage Types and Genetic Variation
SO JOURNAL OF NUTRITION
LA English
DT Article
DE coffee; tea; caffeine; biomarkers; cholesterol; glucose; genetics;
   epidemiology
ID SERUM-CHOLESTEROL CONCENTRATION; REACTIVE PROTEIN-LEVELS; BLACK TEA;
   METABOLIC SYNDROME; DECAFFEINATED COFFEE; OXIDATIVE STRESS;
   RISK-FACTORS; METAANALYSIS; GREEN; ASSOCIATION
AB Background: Mechanisms linking habitual consumption of coffee and tea to the development of type 2 diabetes and cardiovascular diseases remain unclear.
   Objectives: We leveraged dietary, genetic, and biomarker data collected from the UK Biobank to investigate the role of different varieties of coffee and tea in cardiometabolic health.
   Methods: We included data from <= 447,794 participants aged 37-73 y in 2006-2010 who provided a blood sample and completed questionnaires regarding sociodemographic factors, medical history, diet, and lifestyle. Multivariable linear regression was used to examine the association between coffee or tea consumption and blood concentrations of glycated hemoglobin, fasting glucose, total cholesterol, HDL cholesterol, LDL cholesterol, fasting triglycerides (TGs), apoA-1, apoB, lipoprotein-a, and C-reactive protein (CRP). Lifestyle and genetic factors affecting caffeine metabolism, responses, or intake were tested for interactions with beverage intake in relation to biomarker concentrations.
   Results: Compared with coffee nonconsumers, each additional cup of coffee was significantly associated with higher total cholesterol, HDL-cholesterol, and LDL-cholesterol concentrations and lower TG and CRP concentrations in both men and women (P-trend < 0.002). Higher consumption of espresso coffee (>= 2 compared with 0 cups/d) was associated with higher LDL cholesterol in men (beta: 0.110 mmol/L; 95% CI: 0.058, 0.163 mmol/L) and women (beta: 0.161 mmol/L; 95% CI: 0.088, 0.234 mmol/L), whereas no substantial association was observed for instant coffee. Compared with tea nonconsumers, higher tea consumption was associated with lower total and LDL cholesterol and apoB and higher HDL cholesterol (P-trend < 0.002); these associations were similar for black and green tea. Associations were not modified by genetics.
   Conclusions: In the UK Biobank, consumption of certain coffee brews such as espresso had unfavorable associations with blood lipids, whereas consumption of tea had favorable associations. Findings were not modified by genetic variants affecting caffeine metabolism, suggesting a role of noncaffeine constituents of these beverages in cardiometabolic health.
C1 [Cornelis, Marilyn C.] Northwestern Univ, Dept Prevent Med, Feinberg Sch Med, Chicago, IL 60611 USA.
   [van Dam, Rob M.] Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore, Singapore.
   [van Dam, Rob M.] Natl Univ Hlth Syst, Singapore, Singapore.
   [van Dam, Rob M.] Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA.
C3 Northwestern University; Feinberg School of Medicine; National
   University of Singapore; National University of Singapore; Harvard
   University; Harvard T.H. Chan School of Public Health
RP Cornelis, MC (corresponding author), Northwestern Univ, Dept Prevent Med, Feinberg Sch Med, Chicago, IL 60611 USA.
EM marilyn.cornelis@northwestern.edu
RI van Dam, Rob/F-9674-2010
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NR 70
TC 38
Z9 38
U1 1
U2 19
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0022-3166
EI 1541-6100
J9 J NUTR
JI J. Nutr.
PD OCT
PY 2020
VL 150
IS 10
BP 2772
EP 2788
DI 10.1093/jn/nxaa212
PG 17
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA OC8LQ
UT WOS:000579408700023
PM 32805014
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Al-Terki, A
   Abu-Farha, M
   AlKhairi, I
   Cherian, PT
   Sriraman, D
   Shyamsundar, A
   Ali, S
   Almulla, F
   Tuomilehto, J
   Abubaker, JA
AF Al-Terki, Abdulmohsen
   Abu-Farha, Mohamed
   AlKhairi, Irina
   Cherian, Preethi T.
   Sriraman, Devarajan
   Shyamsundar, Ambika
   Ali, Shamsha
   Almulla, Fahd
   Tuomilehto, Jaakko
   Abubaker, Jehad A.
TI Increased Level of Angiopoietin Like Proteins 4 and 8 in People With
   Sleep Apnea
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Article
DE obstructive sleep apnea; ANGPTL4; ANGPTL8; apnea hypopnea index;
   polysomnography; lipid metabolism
ID INTERMITTENT HYPOXIA; LIPOPROTEIN-LIPASE; CIRCULATING BETATROPHIN;
   CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; OXIDATIVE STRESS;
   LIPID-METABOLISM; ANGPTL4; GLUCOSE; GENE
AB Objective: Obstructive sleep apnea (OSA) is a sleep disorder caused by the complete or partial obstruction of the upper airways. The worldwide prevalence of OSA is increasing due to its close association with obesity epidemic and multiple health complications, such as hypertension, cardiovascular disease, and Type 2 diabetes. Angiopoietin-like protein (ANGPTL)-4 and ANGPTL8 (betatrophin) have been suggested to play a role in the development of these diseases through their role in regulating the metabolism of plasma lipid molecules. This study was designed to evaluate ANGPTL4 and 8 levels in an OSA group and a control group to clarify the effect of OSA on ANGPTL4 and 8 levels.
   Methods: In total, 74 subjects were enrolled in this study, including 22 age- and body mass index (BMI)-matched controls with the Apnea Hypopnea Index (AHI) score of <5 events/h and 52 subjects with an AHI score of >5 events/h. Sleep apnea was assessed using a portable sleep test. ANGPTL4 and 8 levels were measured in plasma samples using enzyme-linked immunosorbent assay.
   Results: Mean AHI score (2.5 +/- 1.6) in the control group was significantly lower than that in the OSA group (22.9 +/- 17.9; p < 0.0001). Leptin, interleukin-(IL) 6, insulin, and HOMA-IR values were higher in the OSA group than in the control group. ANGPTL8 level was higher in the OSA group (1130.0 +/- 108.61 pg/mL) than in the control group (809.39 +/- 108.78 pg/mL; p = 0.041). Similarly, ANGPTL4 was higher in the OSA group (179.26 +/- 12.89 ng/mL) than in the control group (142.63 +/- 7.99 ng/mL; p = 0.018).
   Conclusion: Our findings demonstrate that ANGPTL4 and 8 levels were increased in subjects with OSA, suggesting that the upregulation of these lipid metabolism regulators might play a role in lipid dysregulation observed in people with OSA.
C1 [Al-Terki, Abdulmohsen] Dasman Diabet Inst, Med Div, Otolaryngol Head & Neck Surg, Kuwait, Kuwait.
   [Abu-Farha, Mohamed; AlKhairi, Irina; Abubaker, Jehad A.] Dasman Diabet Inst, Biochem & Mol Biol Unit, Kuwait, Kuwait.
   [Cherian, Preethi T.; Sriraman, Devarajan] Dasman Diabet Inst, Natl Dasman Diabet Biobank, Kuwait, Kuwait.
   [Shyamsundar, Ambika; Ali, Shamsha; Almulla, Fahd; Tuomilehto, Jaakko] Dasman Diabet Inst, Res Div, Kuwait, Kuwait.
C3 Dasman Diabetes Institute (DDI); Dasman Diabetes Institute (DDI); Dasman
   Diabetes Institute (DDI); Dasman Diabetes Institute (DDI)
RP Abu-Farha, M; Abubaker, JA (corresponding author), Dasman Diabet Inst, Biochem & Mol Biol Unit, Kuwait, Kuwait.
EM mohamed.abufarha@dasmaninstitute.org; jehad.abubakr@dasmaninstitute.org
RI Abubaker, Jehad/KHV-9373-2024; Abu-Farha, Mohamed/KHW-8579-2024;
   tuomilehto, jaakko/E-6504-2011
OI Cherian, Preethi/0000-0002-2132-3533; Abubaker,
   Jehad/0000-0003-0681-7305; Abu-Farha, Mohamed/0000-0001-8357-1252
FU Kuwait Foundation for the Advancement of Sciences (KFAS) [RA-2015-043]
FX We are grateful to Clinical Laboratory and the Tissue Bank Core Facility
   at DDI for their contribution in handling samples. We are also indebted
   to Kuwait Foundation for the Advancement of Sciences (KFAS) for
   financial support of this research project (RA-2015-043). The
   corresponding authors had full access to all the data in the study and
   had final responsibility for the decision to submit for publication.
   None of the authors have been paid to write this article by a
   pharmaceutical company or other agency.
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NR 56
TC 22
Z9 22
U1 0
U2 2
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD NOV 13
PY 2018
VL 9
AR 651
DI 10.3389/fendo.2018.00651
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA HA1GF
UT WOS:000449959300001
PM 30524367
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Morrissey, C
   Grieve, IC
   Heinig, M
   Atanur, S
   Petretto, E
   Pravenec, M
   Hubner, N
   Aitman, TJ
AF Morrissey, Catherine
   Grieve, Ian C.
   Heinig, Matthias
   Atanur, Santosh
   Petretto, Enrico
   Pravenec, Michal
   Hubner, Norbert
   Aitman, Timothy J.
TI Integrated genomic approaches to identification of candidate genes
   underlying metabolic and cardiovascular phenotypes in the spontaneously
   hypertensive rat
SO PHYSIOLOGICAL GENOMICS
LA English
DT Article
DE expression quantitative trait locus; spontaneously hypertensive rat;
   quantitative trait transcript; sequence variation
ID QUANTITATIVE TRAIT LOCI; RECOMBINANT-INBRED STRAINS; HEPATIC ANTIOXIDANT
   STATUS; HUMAN HAPTOGLOBIN GENE; BLOOD-PRESSURE; OXIDATIVE STRESS;
   SCAVENGER RECEPTOR; FATTY-ACID; EXPRESSION; SEQUENCE
AB Morrissey C, Grieve IC, Heinig M, Atanur S, Petretto E, Pravenec M, Hubner N, Aitman TJ. Integrated genomic approaches to identification of candidate genes underlying metabolic and cardiovascular phenotypes in the spontaneously hypertensive rat. Physiol Genomics 43: 1207-1218, 2011. First published August 26, 2011; doi:10.1152/physiolgenomics.00210.2010.-The spontaneously hypertensive rat (SHR) is a widely used rodent model of hypertension and metabolic syndrome. Previously we identified thousands of cis-regulated expression quantitative trait loci (eQTLs) across multiple tissues using a panel of rat recombinant inbred (RI) strains derived from Brown Norway and SHR progenitors. These cis-eQTLs represent potential susceptibility loci underlying physiological and pathophysiological traits manifested in SHR. We have prioritized 60 cis-eQTLs and confirmed differential expression between the parental strains by quantitative PCR in 43 (72%) of the eQTL transcripts. Quantitative trait transcript (QTT) analysis in the RI strains showed highly significant correlation between cis-eQTL transcript abundance and clinically relevant traits such as systolic blood pressure and blood glucose, with the physical location of a subset of the cis-eQTLs colocalizing with "physiological" QTLs (pQTLs) for these same traits. These colocalizing correlated cis-eQTLs (c3-eQTLs) are highly attractive as primary susceptibility loci for the colocalizing pQTLs. Furthermore, sequence analysis of the c3-eQTL genes identified single nucleotide polymorphisms (SNPs) that are predicted to affect transcription factor binding affinity, splicing and protein function. These SNPs, which potentially alter transcript abundance and stability, represent strong candidate factors underlying not just eQTL expression phenotypes, but also the correlated metabolic and physiological traits. In conclusion, by integration of genomic sequence, eQTL and QTT datasets we have identified several genes that are strong positional candidates for pathophysiological traits observed in the SHR strain. These findings provide a basis for the functional testing and ultimate elucidation of the molecular basis of these metabolic and cardiovascular phenotypes.
C1 [Morrissey, Catherine; Grieve, Ian C.; Atanur, Santosh; Aitman, Timothy J.] Univ London Imperial Coll Sci Technol & Med, MRC Clin Sci Ctr, Physiol Genom & Med Grp, Fac Med, London W12 0NN, England.
   [Heinig, Matthias; Hubner, Norbert] Max Delbruck Ctr Mol Med, Berlin, Germany.
   [Petretto, Enrico] Univ London Imperial Coll Sci Technol & Med, MRC Clin Sci Ctr, Integrat Genom & Med Grp, London W12 0NN, England.
   [Petretto, Enrico] Univ London Imperial Coll Sci Technol & Med, Fac Med, Dept Epidemiol & Publ Hlth, London W12 0NN, England.
   [Pravenec, Michal] Acad Sci Czech Republic, Inst Physiol, Prague, Czech Republic.
C3 Imperial College London; Helmholtz Association; Max Delbruck Center for
   Molecular Medicine; Imperial College London; Imperial College London;
   Czech Academy of Sciences; Institute of Physiology of the Czech Academy
   of Sciences
RP Aitman, TJ (corresponding author), Univ London Imperial Coll Sci Technol & Med, MRC Clin Sci Ctr, Physiol Genom & Med Grp, Fac Med, Du Cane Rd, London W12 0NN, England.
EM t.aitman@imperial.ac.uk
RI Heinig, Matthias/IZQ-2092-2023; van Heesch, Sebastiaan/AAT-6595-2020;
   Pravenec, Michal/B-1666-2012
OI Aitman, Timothy/0000-0002-7875-4502; Heinig,
   Matthias/0000-0002-5612-1720; Pravenec, Michal/0000-0001-9197-5871
FU MRC Clinical Sciences Centre; Imperial College BHF Centre of Research
   Excellence; Wellcome Trust [069962/Z/02/Z]; Grant Agency of the Czech
   Republic [301/08/0166]; Ministry of Education of the Czech Republic
   [ME10019]; MRC [MC_U120061454, MC_U120097112] Funding Source: UKRI
FX This work was primarily supported by intramural funding from the MRC
   Clinical Sciences Centre, by the Imperial College BHF Centre of Research
   Excellence, by a Wellcome Trust studentship (069962/Z/02/Z) to I. C.
   Grieve, and by the Grant Agency of the Czech Republic (grant
   301/08/0166) and the Ministry of Education of the Czech Republic (grant
   ME10019) (M. Pravenec).
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NR 72
TC 22
Z9 26
U1 0
U2 6
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 1094-8341
J9 PHYSIOL GENOMICS
JI Physiol. Genomics
PD NOV
PY 2011
VL 43
IS 21
BP 1207
EP 1218
DI 10.1152/physiolgenomics.00210.2010
PG 12
WC Cell Biology; Genetics & Heredity; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Genetics & Heredity; Physiology
GA 844OW
UT WOS:000296758000003
PM 21846806
OA Green Published
DA 2025-06-11
ER

PT J
AU Poelzl, G
   Eberl, C
   Achrainer, H
   Doerler, J
   Pachinger, O
   Frick, M
   Ulmer, H
AF Poelzl, Gerhard
   Eberl, Christian
   Achrainer, Helene
   Doerler, Jakob
   Pachinger, Otmar
   Frick, Matthias
   Ulmer, Hanno
TI Prevalence and Prognostic Significance of Elevated γ-Glutamyltransferase
   in Chronic Heart failure
SO CIRCULATION-HEART FAILURE
LA English
DT Article
DE gamma-glutamyltransferase; heart failure; prognosis; liver; enzymes
ID MIDDLE-AGED MEN; CARDIOVASCULAR-DISEASE MORTALITY; OXIDATIVE STRESS;
   METABOLIC SYNDROME; LIVER DYSFUNCTION; AUSTRIAN ADULTS; RISK;
   ATHEROSCLEROSIS; MARKER; ASSOCIATION
AB Background-Serum gamma-glutamyltransferase (GGT) is associated with incident cardiovascular diseases and is a potential risk factor for disease mortality. We investigated the relevance of circulating GGT in chronic heart failure.
   Methods and Results-From 2000 to 2007 clinical and laboratory variables of 1033 consecutive outdoor patients with heart failure were evaluated. Follow-up (mean, 34.4 months) was available in 998 patients. The end point was defined as death from any cause or heart transplantation. A forward stepwise Cox proportional hazards regression model for sex-stratified data was used. Prevalence of elevated GGT was 42.9% in men (GGT >65 U/L) and 50.2% in women (GGT >38 U/L), which was higher than for sex- and age-matched healthy subjects (18.6% in men, 19.2% in women) derived from a large historical control group. GGT was associated with severity of heart failure as assessed by New York Heart Association class, left-ventricular ejection fraction, and amino-terminal pro-B-type natriuretic peptide. The end point was recorded in 302 patients. Compared with the lowest GGT quintile, sex-stratified hazard ratios for patients in the highest quintile were 2.88 (1.99 to 4.17) in the univariate model and 1.87 (1.28 to 2.74) in the adjusted model (P<0.001). Corresponding 5-year cumulative event rates were 47% and 74%, respectively. Adjusted hazard ratios for elevated GGT was 2.9 (1.64 to 5.17) for patients in New York Heart Association I/II, and 1.2 (0.75 to 2.05) for patients in New York Heart Association III/IV, respectively (P=0.003, for the GGT-New York Heart Association class interaction).
   Conclusions-Prevalence of elevated GGT is high in patients with chronic heart failure. The GGT levels are associated with disease severity. Increased GGT is an independent predictor of death or heart transplantation. GGT may provide additional prognostic information, especially in patients with mild heart failure. (Circ Heart Fail. 2009;2:294-302.)
C1 [Poelzl, Gerhard; Eberl, Christian; Achrainer, Helene; Doerler, Jakob; Pachinger, Otmar; Frick, Matthias] Innsbruck Med Univ, Clin Div Cardiol, A-6020 Innsbruck, Austria.
   [Ulmer, Hanno] Innsbruck Med Univ, Dept Med Stat, A-6020 Innsbruck, Austria.
C3 Medical University of Innsbruck; Medical University of Innsbruck
RP Poelzl, G (corresponding author), Innsbruck Med Univ, Clin Div Cardiol, Anichstr 35, A-6020 Innsbruck, Austria.
EM gerhard.poelzl@uki.at
RI Ulmer, Hanno/S-6615-2019
OI Ulmer, Hanno/0000-0001-5911-1002
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NR 38
TC 68
Z9 69
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1941-3289
J9 CIRC-HEART FAIL
JI Circ.-Heart Fail.
PD JUL
PY 2009
VL 2
IS 4
BP 294
EP 302
DI 10.1161/CIRCHEARTFAILURE.108.826735
PG 9
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 477PF
UT WOS:000268530300004
PM 19808352
OA Bronze
DA 2025-06-11
ER

PT J
AU Ge, YY
   Huang, SS
   Li, Y
   Zhang, Z
   Kong, M
   Cui, NN
   Tan, L
   Guo, S
   Wang, SS
   Luo, C
   Hao, LP
   Wu, YJ
   Yang, XF
AF Ge, Yanyan
   Huang, Shanshan
   Li, Yan
   Zhang, Zhen
   Kong, Man
   Cui, Ningning
   Tan, Le
   Guo, Shu
   Wang, Shanshan
   Luo, Can
   Hao, Liping
   Wu, Yuanjue
   Yang, Xuefeng
TI Pregnancy thiamine and riboflavin intake and the risk of gestational
   diabetes mellitus: A prospective cohort study
SO AMERICAN JOURNAL OF CLINICAL NUTRITION
LA English
DT Article
DE cohort study; daily thiamine intake; daily riboflavin intake;
   gestational diabetes mellitus; pregnancy nutrition
ID METABOLIC SYNDROME; GLUCOSE-TOLERANCE; OXIDATIVE STRESS; BIRTH-WEIGHT;
   ASSOCIATION; HYPERGLYCEMIA; DEFICIENCY; SUPPLEMENTATION; OBESITY;
   INSULIN
AB Background: Thiamine and riboflavin deficiencies exist to varying degrees worldwide, especially in developing countries. Evidence regarding the association between thiamine and riboflavin intake and gestational diabetes mellitus (GDM) is scarce.
   Objectives: We aimed to evaluate the association of thiamine and riboflavin intake during pregnancy, including dietary source and supplementation, with GDM risk in a prospective cohort study.
   Methods: We included 3036 pregnant women (923 in the first trimester and 2113 in the second trimester) from the Tongji Birth Cohort. A validated semi-quantitative food frequency questionnaire and a lifestyle questionnaire were used to assess thiamine and riboflavin intake from dietary source and supplementation, respectively. GDM was diagnosed using the 75 g 2-h oral glucose tolerance test at 24-28 weeks of gestation. A modified Poisson regression or logistic regression model was used to evaluate the association between thiamine and riboflavin intake and GDM risk.
   Results: Dietary intake of thiamine and riboflavin was at low levels during pregnancy. In the fully adjusted model, compared with participants in quartile 1 (Q1), those who had more total thiamine and riboflavin intake had a lower risk of GDM during the first trimester [thiamine: Q2: RR: 0.58 (95% CI: 0.34, 0.98); Q3: RR: 0.45 (95% CI: 0.24, 0.84); Q4: RR: 0.35 (95% CI: 0.17, 0.72), P for trend = 0.002; riboflavin: Q2: RR: 0.63 (95% CI: 0.37, 1.09); Q3: RR: 0.45 (95% CI: 0.24, 0.87); Q4: RR: 0.39 (95% CI: 0.19, 0.79), P for trend = 0.006]. This association was also observed during the second trimester. Similar results were observed for the association between thiamine and riboflavin supplement use but not dietary intake and GDM risk.
   Conclusions: Higher intake of thiamine and riboflavin during pregnancy is associated with a lower incidence of GDM.
C1 [Ge, Yanyan; Huang, Shanshan; Li, Yan; Zhang, Zhen; Cui, Ningning; Tan, Le; Guo, Shu; Wang, Shanshan; Luo, Can; Hao, Liping; Yang, Xuefeng] Huazhong Univ Sci & Technol, MOE Key Lab Environm & Hlth, Hubei Key Lab Food Nutr & Safety, Dept Nutr & Food Hyg,Sch Publ Hlth,Tongji Med Col, 13 Hangkong Rd, Wuhan 430030, Hubei, Peoples R China.
   [Kong, Man] Huazhong Univ Sci & Technol, Cent Hosp Wuhan, Tongji Med Coll, Wuhan 430030, Hubei, Peoples R China.
   [Wu, Yuanjue] Guangzhou Med Univ, Sch Publ Hlth, Guangzhou 511436, Guangdong, Peoples R China.
   [Wu, Yuanjue] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Clin Nutr, Wuhan 430022, Hubei, Peoples R China.
C3 Huazhong University of Science & Technology; Huazhong University of
   Science & Technology; Guangzhou Medical University; Huazhong University
   of Science & Technology
RP Yang, XF (corresponding author), Huazhong Univ Sci & Technol, MOE Key Lab Environm & Hlth, Hubei Key Lab Food Nutr & Safety, Dept Nutr & Food Hyg,Sch Publ Hlth,Tongji Med Col, 13 Hangkong Rd, Wuhan 430030, Hubei, Peoples R China.; Wu, YJ (corresponding author), Guangzhou Med Univ, Sch Publ Hlth, Guangzhou 511436, Guangdong, Peoples R China.; Wu, YJ (corresponding author), Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Clin Nutr, Wuhan 430022, Hubei, Peoples R China.
EM wyj190730@163.com; xxyxf@hust.edu.cn
RI li, yan/GXH-7943-2022; Yang, Xuefeng/AAB-7163-2019; Wang,
   Shan-Shan/S-8186-2019
OI Wu, Yuanjue/0009-0007-1789-832X
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NR 43
TC 7
Z9 7
U1 2
U2 23
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0002-9165
EI 1938-3207
J9 AM J CLIN NUTR
JI Am. J. Clin. Nutr.
PD FEB
PY 2023
VL 117
IS 2
BP 426
EP 435
DI 10.1016/j.ajcnut.2022.11.014
EA FEB 2023
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA D8MT8
UT WOS:000971221000001
PM 36811572
OA Bronze
DA 2025-06-11
ER

PT J
AU Halvorson, BD
   Menon, NJ
   Goldman, D
   Frisbee, SJ
   Goodwill, AG
   Butcher, JT
   Stapleton, PA
   Brooks, SD
   d'Audiffret, AC
   Wiseman, RW
   Lombard, JH
   Brock, RW
   Olfert, IM
   Chantler, PD
   Frisbee, JC
AF Halvorson, Brayden D.
   Menon, Nithin J.
   Goldman, Daniel
   Frisbee, Stephanie J.
   Goodwill, Adam G.
   Butcher, Joshua T.
   Stapleton, Phoebe A.
   Brooks, Steven D.
   d'Audiffret, Alexandre C.
   Wiseman, Robert W.
   Lombard, Julian H.
   Brock, Robert W.
   Olfert, I. Mark
   Chantler, Paul D.
   Frisbee, Jefferson C.
TI The development of peripheral microvasculopathy with chronic metabolic
   disease in obese Zucker rats: a retrograde emergence?
SO AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
LA English
DT Article
DE microcirculation; microvascular systems; peripheral vascular disease;
   rat models of metabolic syndrome; skeletal muscle fatigue
ID RED-CELL FLOW; SKELETAL-MUSCLE; PERFUSION HETEROGENEITY; ENDOTHELIAL
   DYSFUNCTION; RESISTANCE ARTERIES; CHRONIC STRESS; FEMALE RATS;
   HEMATOCRIT; RAREFACTION; CAPILLARY
AB The study of peripheral vasculopathy with chronic metabolic disease is challenged by divergent contributions from spatial (the level of resolution or specific tissue being studied) and temporal origins (evolution of the developing impairments in time). Over many years of studying the development of skeletal muscle vasculopathy and its functional implications, we may be at the point of presenting an integrated conceptual model that addresses these challenges within the obese Zucker rat (OZR) model. At the early stages of metabolic disease, where systemic markers of elevated cardiovascular disease risk are present, the only evi-dence of vascular dysfunction is at postcapillary and collecting venules, where leukocyte adhesion/rolling is elevated with impaired venular endothelial function. As metabolic disease severity and duration increases, reduced microvessel density becomes evident as well as increased variability in microvascular hematocrit. Subsequently, hemodynamic impairments to distal arteriolar networks emerge, manifesting as increasing perfusion heterogeneity and impaired arteriolar reactivity. This retrograde "wave of dysfunction " continues, creating a condition wherein deficiencies to the distal arteriolar, capillary, and venular microcir-culation stabilize and impairments to proximal arteriolar reactivity, wall mechanics, and perfusion distribution evolve. This proxi-mal arteriolar dysfunction parallels increasing failure in fatigue resistance, hyperemic responses, and O2 uptake within self-perfused skeletal muscle. Taken together, these results present a conceptual model for the retrograde development of periph-eral vasculopathy with chronic metabolic disease and provide insight into the timing and targeting of interventional strategies to improve health outcomes.NEW & NOTEWORTHY Working from an established database spanning multiple scales and times, we studied progression of peripheral microvascular dysfunction in chronic metabolic disease. The data implicate the postcapillary venular endothelium as the initiating site for vasculopathy. Indicators of dysfunction, spanning network structures, hemodynamics, vascular reactivity, and perfusion progress in an insidious retrograde manner to present as functional impairments to muscle blood flow and perform-ance much later. The silent vasculopathy progression may provide insight into clinical treatment challenges.
C1 [Halvorson, Brayden D.; Menon, Nithin J.; Goldman, Daniel; Frisbee, Jefferson C.] Univ Western Ontario, Dept Med Biophys, London, ON, Canada.
   [Halvorson, Brayden D.; Menon, Nithin J.; Goldman, Daniel; Frisbee, Jefferson C.] Univ Western Ontario, Lab Med, London, ON, Canada.
   [Frisbee, Stephanie J.] Univ Western Ontario, Dept Pathol, London, ON, Canada.
   [Goodwill, Adam G.] Northeastern Ohio Med Univ, Dept Integrat Med Sci, Rootstown, OH USA.
   [Butcher, Joshua T.] Oklahoma State Univ, Dept Physiol Sci, Stillwater, OK USA.
   [Stapleton, Phoebe A.] Rutgers State Univ, Dept Pharmacol & Toxicol, Piscataway, NJ USA.
   [Brooks, Steven D.] NIAID, Physiol Unit, Lab Malaria & Vector Res, Rockville, MD USA.
   Rush Med Coll, Dept Cardiovasc & Thorac Surg, Chicago, IL USA.
   [Wiseman, Robert W.] Michigan State Univ, Dept Physiol, E Lansing, MI USA.
   [Wiseman, Robert W.] Michigan State Univ, Dept Radiol, E Lansing, MI USA.
   [Lombard, Julian H.] Med Coll Wisconsin, Dept Physiol, Milwaukee, WI USA.
   [Brock, Robert W.; Olfert, I. Mark] West Virginia Univ, Dept Physiol & Pharmacol, Morgantown, WV USA.
C3 Western University (University of Western Ontario); Western University
   (University of Western Ontario); Western University (University of
   Western Ontario); University System of Ohio; Northeast Ohio Medical
   University (NEOMED); Oklahoma State University System; Oklahoma State
   University - Stillwater; Rutgers University System; Rutgers University
   New Brunswick; National Institutes of Health (NIH) - USA; NIH National
   Institute of Allergy & Infectious Diseases (NIAID); Rush University;
   Michigan State University; Michigan State University; Medical College of
   Wisconsin; West Virginia University
RP Frisbee, JC (corresponding author), Univ Western Ontario, Dept Med Biophys, London, ON, Canada.; Frisbee, JC (corresponding author), Univ Western Ontario, Lab Med, London, ON, Canada.
EM jfrisbee@uwo.ca
RI Butcher, Joshua/ABH-7212-2022; Halvorson, Brayden/IXN-1735-2023;
   Goldman, Daniel/CAI-2887-2022; Goodwill, Adam/N-4889-2016
OI Frisbee, Jefferson/0000-0003-2751-0599; Goldman,
   Daniel/0000-0002-8707-5536; Frisbee, Stephanie/0000-0003-1526-1839;
   Brooks, Steven/0000-0001-7357-1419; Butcher, Joshua/0000-0002-7341-1949;
   Goodwill, Adam/0000-0003-3701-3713
FU National Institutes of Health (NIH) [R01 DK64668, DK950210, DK127694,
   HL065289, K01AG064121/OCAST HR21-045-1, HL128242, AG060731, RR 2865AR];
   American Heart Association [0330194 N, 0740129 N, 13IRG14330015];
   Canadian Institutes for Health Research Grant [389769]; Natural Sciences
   and Engineering Research Council (Canada) [RGPIN-2018--05450,
   RGPIN-2019--06086]; National Institute of Allergy and Infectious
   Diseases (NIAID) Research Program/NIAID/NIH; American Heart Association
   (AHA) [13IRG14330015] Funding Source: American Heart Association (AHA)
FX This study was funded by National Institutes of Health (NIH) Grants R01
   DK64668 (to J.C.F.) , DK950210 and DK127694 (to R.W.W.) , HL065289 (to
   J.H.L.) , K01AG064121/OCAST HR21-045-1 (to J.T.B.) , and HL128242,
   AG060731, and RR 2865AR; American Heart Association Grants 0330194 N,
   0740129 N, and 13IRG14330015 (to J.C.F.) ; Canadian Institutes for
   Health Research Grant 389769 (to J.C.F.) ; and Natural Sciences and
   Engineering Research Council (Canada) Grants RGPIN-2018--05450 (to
   J.C.F.) and RGPIN-2019--06086 (to D.G.) . S.D.B. is supported by
   National Institute of Allergy and Infectious Diseases (NIAID) Research
   Program/NIAID/NIH.
CR American Heart Association, 2022, WHAT IS DIAB
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NR 60
TC 6
Z9 6
U1 0
U2 1
PU AMER PHYSIOLOGICAL SOC
PI Rockville
PA 6120 Executive Blvd, Suite 600, Rockville, MD, UNITED STATES
SN 0363-6135
EI 1522-1539
J9 AM J PHYSIOL-HEART C
JI Am. J. Physiol.-Heart Circul. Physiol.
PD SEP
PY 2022
VL 323
IS 3
BP H475
EP H489
DI 10.1152/ajpheart.00264.2022
PG 15
WC Cardiac & Cardiovascular Systems; Physiology; Peripheral Vascular
   Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Physiology
GA 6S3BE
UT WOS:000892865400004
PM 35904886
OA Green Published
DA 2025-06-11
ER

PT J
AU Yunusova, NV
   Dandarova, EE
   Svarovsky, DA
   Denisov, NS
   Kostromitsky, DN
   Patysheva, MR
   Cheremisina, OV
   Spirina, LV
AF Yunusova, N. V.
   Dandarova, E. E.
   Svarovsky, D. A.
   Denisov, N. S.
   Kostromitsky, D. N.
   Patysheva, M. R.
   Cheremisina, O. V.
   Spirina, L. V.
TI Production and Internalization of Extracellular Vesicles in Norm and
   under Conditions of Hyperglycemia and Insulin Resistance
SO BIOCHEMISTRY MOSCOW-SUPPLEMENT SERIES B-BIOMEDICAL CHEMISTRY
LA English
DT Article
DE extracellular vesicles; exosomes; internalization; hyperglycemia;
   insulin resistance; type 2 diabetes mellitus
ID METABOLIC SYNDROME; DIABETES-MELLITUS; ADIPOSE-TISSUE; EXOSOMES;
   MICROPARTICLES; OBESITY; CELLS; INFLAMMATION; MICRORNAS; PATHWAYS
AB Extracellular vesicles (EVs) are spherical functionally important structures of cell membrane origin ranging in size from 40 nm to 5000 nm. They are involved in the horizontal transfer of mainly proteins and microRNAs. The mechanisms of EV internalization include clathrin-dependent endocytosis, caveolin-dependent endocytosis, raft-mediated endocytosis, and macropinocytosis. Type 2 diabetes mellitus (T2DM) is a common group of metabolic disorders in adults; the incidence and prevalence of T2DM increase in parallel with the obesity epidemic. Since adipose tissue plays a key role in the development of insulin resistance, EVs secreted by adipose tissue may be considered as an information transmitter in this process. EVs of the adipocyte origin are predominantly captured up by tissue macrophages, adipocytes themselves, hepatocytes, and skeletal muscles. The EV uptake promotes M1 polarization of macrophages, a decrease in glucose uptake by hepatocytes and myocytes due to the transfer of functionally active microRNAs influencing carbohydrate and lipid metabolism. Patients with T2DM and impaired glucose tolerance, have a significantly higher level of CD235a-positive (erythrocyte) EVs and a trend to the increase in CD68-positive (leukocyte) and CD62p-positive (platelet/endothelial cells) EVs. The levels of CD31+/CD146-positive EVs (endothelial cells) were comparable between diabetic and euglycemic patients. EVs from diabetic patients were preferentially internalized by monocytes (predominantly classical and transitional, and to a lesser extent nonclassical monocyte fractions) and B cells as compared to euglycemic patients. Internalization of EVs from patients with T2DM by monocytes led to a decrease in their apoptosis, changes in differentiation, and suppression of monocyte reactions controlling oxidative stress. Thus, insulin resistance increases the secretion of EVs, which are pref- erentially internalized by monocytes and alter their function. EVs are considered as sources of promising clinical markers of insulin resistance, complications of diabetes mellitus (endothelial dysfunction, retinopathy, nephropathy, neuropathy), and EV markers can also be used to monitor the effectiveness of therapy for these complications.
C1 [Yunusova, N. V.; Dandarova, E. E.; Svarovsky, D. A.; Denisov, N. S.; Spirina, L. V.] Siberian State Med Univ, Moskovskiy Tract 2, Tomsk 634050, Russia.
   [Yunusova, N. V.; Kostromitsky, D. N.; Patysheva, M. R.; Cheremisina, O. V.; Spirina, L. V.] Tomsk Natl Res Med Ctr, Canc Res Inst, Kooperativniy Per 5, Tomsk 634009, Russia.
C3 Siberian State Medical University; Russian Academy of Sciences; Tomsk
   National Research Medical Center; Cancer Research Institute of the RAS
RP Svarovsky, DA (corresponding author), Siberian State Med Univ, Moskovskiy Tract 2, Tomsk 634050, Russia.
EM svarovsky.d.a@gmail.com
RI Cheremisina, Olga/C-9259-2012; Spirina, Liudmila/A-7760-2012;
   KOSTROMITSKIY, DMITRIY/ABB-6958-2021
OI Kostromitsky, Dmitry/0000-0001-5691-2349
FU Siberian State Medical University
FX The study was supported by a grant of Siberian State Medical University
   "Molecular and biochemical mechanisms of the infectious and
   non-infectious somatic diseases based on the proteolysis regulation and
   the formation of metabolic disorders."
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NR 51
TC 0
Z9 1
U1 0
U2 3
PU MAIK NAUKA-INTERPERIODICA
PI MOSCOW
PA PROFSOYUZNAYA UL 90, MOSCOW, 117997, RUSSIA
SN 1990-7508
EI 1990-7516
J9 BIOCHEM MOSC SUPPL B
JI Biochem. Mosc.-Suppl. Ser. B-Biomed. Chem.
PD JUN
PY 2022
VL 16
IS 2
BP 104
EP 112
DI 10.1134/S199075082202010X
PG 9
WC Biochemistry & Molecular Biology
WE Emerging Sources Citation Index (ESCI)
SC Biochemistry & Molecular Biology
GA 1I1CX
UT WOS:000796975300003
DA 2025-06-11
ER

PT J
AU Hwangbo, H
   Kim, MY
   Ji, SY
   Kim, SY
   Lee, H
   Kim, GY
   Park, C
   Keum, YS
   Hong, SH
   Cheong, J
   Choi, YH
AF Hwangbo, Hyun
   Kim, Min Yeong
   Ji, Seon Yeong
   Kim, So Young
   Lee, Hyesook
   Kim, Gi-Young
   Park, Cheol
   Keum, Young-Sam
   Hong, Su Hyun
   Cheong, Jaehun
   Choi, Yung Hyun
TI Auranofin Attenuates Non-Alcoholic Fatty Liver Disease by Suppressing
   Lipid Accumulation and NLRP3 Inflammasome-Mediated Hepatic Inflammation
   In Vivo and In Vitro
SO ANTIOXIDANTS
LA English
DT Article
DE auranofin; NAFLD; hepatic inflammation; lipid accumulation; NLRP3
   inflammasome
ID HEPATOCELLULAR-CARCINOMA; NAFLD; CELLS; ACTIVATION; STEATOSIS; FIBROSIS;
   PATHWAY; NASH; MICE
AB Non-alcoholic fatty liver disease (NAFLD) causes liver dysfunction and is associated with obesity and type 2 diabetes. Chronic inflammation is associated not only with the development of NAFLD, but also with hepatic diseases, including steatohepatitis, cirrhosis, and hepatocellular carcinoma. Auranofin is a treatment for rheumatoid arthritis and has recently been reported to have potential effects against a variety of diseases, including inflammation, cancer, and viral infection. In this study, auranofin may be considered as a new treatment for the management of metabolic syndrome, as well as in the treatment of NAFLD through immunomodulation. To determine the effect of auranofin on NAFLD, C57BL/6 mice were randomly grouped, fed a regular diet or a high fat diet (HFD), and injected with normal saline or auranofin for 8 weeks. Auranofin significantly decreased the body weight, epididymal fat weight, serum aspartate aminotransferase (AST), and glucose, as well as the serum triglyceride, cholesterol, and low-density lipoprotein cholesterol levels as compared to the HFD group. We also observed that hepatic steatosis was increased in the HFD group and was suppressed by auranofin treatment. In addition, auranofin suppressed the expressions of interleukin (IL)-1 beta, IL-18, caspase-1, and the NOD-like receptor family pyrin domain containing 3 (NLRP3) in the liver tissue. Furthermore, the expression of NADPH oxidase 4 and peroxisome proliferator-activated receptor gamma (PPAR gamma), which are a major source of oxidative stress and a regulator of adipogenesis, respectively, were also decreased by auranofin. In addition, primary mouse hepatocytes were incubated with lipopolysaccharide (LPS) and palmitic acid (PA) to induce lipid accumulation and hepatic inflammation for an in vitro model. Auranofin could significantly inhibit LPS- and PA-induced inflammatory activity including nitric oxide and NLRP3 inflammasome-mediated cytokines. The results of this study demonstrate that auranofin treatment inhibits the characteristics of NAFLD through the inhibition of NLRP3 inflammasome. Therefore, auranofin may have potential as a candidate for improving NAFLD symptoms.
C1 [Hwangbo, Hyun; Kim, So Young; Cheong, Jaehun] Pusan Natl Univ, Dept Mol Biol, Busan 46241, South Korea.
   [Hwangbo, Hyun; Hong, Su Hyun; Choi, Yung Hyun] Dong Eui Univ, Coll Korean Med, Dept Biochem, Busan 47227, South Korea.
   [Kim, Min Yeong; Ji, Seon Yeong; Kim, So Young; Lee, Hyesook; Choi, Yung Hyun] Dong Eui Univ, Antiaging Res Ctr, Busan 47340, South Korea.
   [Kim, Gi-Young] Jeju Natl Univ, Sch Marine Biomed Sci, Dept Marine Life Sci, Jeju 63243, South Korea.
   [Park, Cheol] Dong Eui Univ, Coll Liberal Studies, Div Basic Sci, Busan 47340, South Korea.
   [Keum, Young-Sam] Dongguk Univ, Coll Pharm, Goyang 10326, South Korea.
   [Keum, Young-Sam] Dongguk Univ, Integrated Res Inst Drug Dev, Goyang 10326, South Korea.
C3 Pusan National University; Dong-Eui University; Dong-Eui University;
   Jeju National University; Dong-Eui University; Dongguk University;
   Dongguk University
RP Cheong, J (corresponding author), Pusan Natl Univ, Dept Mol Biol, Busan 46241, South Korea.; Choi, YH (corresponding author), Dong Eui Univ, Coll Korean Med, Dept Biochem, Busan 47227, South Korea.; Choi, YH (corresponding author), Dong Eui Univ, Antiaging Res Ctr, Busan 47340, South Korea.
EM hbhyun2003@naver.com; ilytoo365@deu.ac.kr; 14602@deu.ac.kr;
   immunkim@jejunu.ac.kr; 14769@deu.ac.kr; immunkim@jejunu.ac.kr;
   parkch@deu.ac.kr; keum03@dongguk.edu; hongsh@deu.ac.kr;
   molecule85@pusan.ac.kr; choiyh@deu.ac.kr
RI Kim, Kyoungmi/AEP-3965-2022; Kim, So-Young/JFS-7698-2023; Kim,
   Kyoung-Sook/A-7768-2017
OI Kim, Gi-Young/0000-0002-6878-0790; HwangBo, Hyun/0000-0003-2180-1205;
   Lee, Hyesook/0000-0003-3546-9370; Kim, So Young/0000-0002-3238-6900
FU Basic Science Research Program through the National Research Foundation
   of Korea (NRF) - Korea government, Korea [2018R1A2B200570513,
   2019R1F1A105809412]
FX This research was funded by Basic Science Research Program through the
   National Research Foundation of Korea (NRF) grant funded by the Korea
   government (2018R1A2B200570513 and 2019R1F1A105809412), Korea.
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NR 56
TC 33
Z9 33
U1 2
U2 17
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD NOV
PY 2020
VL 9
IS 11
AR 1040
DI 10.3390/antiox9111040
PG 13
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA OW4US
UT WOS:000592884300001
PM 33114221
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Gozel, N
   Oral, K
   Ozdemir, FA
   Onalan, E
   Kuloglu, T
   Aydin, S
   Karatas, A
   Kilinç, F
AF Gozel, Nevzat
   Oral, Kubra
   Ozdemir, Fethi Ahmet
   Onalan, Erhan
   Kuloglu, Tuncay
   Aydin, Suleyman
   Karatas, Ahmet
   Kilinc, Faruk
TI An investigation of saliva and plasma levels of urotensin 2 in recently
   diagnosed type 2 diabetes mellitus patients on metformin treatment
SO ENDOKRYNOLOGIA POLSKA
LA English
DT Article
DE type 2 diabetes mellitus; metformin; urotensin 2
ID INCREASED EXPRESSION; OXIDATIVE STRESS; II RECEPTOR; ASSOCIATION;
   ACTIVATOR; HEALTH
AB Introduction: Diabetes mellitus (DM) is a primary disease of the carbohydrate metabolism that is characterised by absolute or relative insulin deficiency, or insulin resistance. Although life expectancy is low for diabetic patients, the prognosis has been improved in recent decades. Metformin is an oral antidiabetic that reduces insulin resistance and plasma glucose levels by decreasing glucose production in the liver. It can be used as a standalone treatment or in combination with other antidiabetic medications or insulin. Urotensin 2 (U-II), which is one of the most effective known vasoconstrictor peptides, was observed to act as a vasoconstrictor in diseases such as hypertension and heart failure, and to induce vasodilation in healthy volunteers. Some studies have proposed that the activation of the U-II system could lead to metabolic syndrome. Certain studies have determined a link between DM and U-II. However, there exist no studies on the effects of U-II in recently diagnosed type 2 DM patients after metformin treatment.
   This study aims to investigate the plasma and saliva levels of U-II at diagnosis and after a three-month metformin treatment in recently diagnosed type 2 DM patients, and to compare these levels to those of healthy volunteers.
   Material and methods: Our study compared 30 recently diagnosed type 2 DM patients to their states after three-month metformin treatment and 30 healthy volunteers.
   Results: When compared with the control group, there was no significant increase in the plasma and saliva U-II levels of recently diagnosed type 2 DM patients. We determined a statistically significant increase in the plasma and saliva ureotensin-2 levels of recently diagnosed type 2 DM patients after a three-month metformin treatment (p < 0.05).
   Conclusions: It was concluded that the patients with type 2 DM have a multifactorial aetiopathogenesis and an increase in U-II levels after metformin treatment. Metformin has no known effect on the U-II metabolism; therefore, the findings need confirmation through more clinical and experimental studies with more participants.
C1 [Gozel, Nevzat; Oral, Kubra; Onalan, Erhan] Firat Univ, Dept Internal Med, Fac Med, Elazig, Turkey.
   [Ozdemir, Fethi Ahmet] Bingol Univ, Fac Sci & Art, Dept Mol Biol & Genet, Bingol, Turkey.
   [Kuloglu, Tuncay] Firat Univ, Dept Histol, Fac Med, Elazig, Turkey.
   [Aydin, Suleyman] Firat Univ, Dept Biochem, Fac Med, Elazig, Turkey.
   [Karatas, Ahmet] Firat Univ, Dept Rheumatol, Fac Med, Elazig, Turkey.
   [Kilinc, Faruk] Firat Univ, Dept Endocrinol, Fac Med, Elazig, Turkey.
C3 Firat University; Bingol University; Firat University; Firat University;
   Firat University; Firat University
RP Gozel, N (corresponding author), Firat Univ, Dept Internal Med, Fac Med, Elazig, Turkey.
EM drngozel@hotmail.com
RI Aydin, Suleyman/GLQ-8843-2022; karatas, ahmet/E-7046-2016; kuloğlu,
   tuncay/W-2310-2018
OI ozdemir, Fethi Ahmet/0000-0001-7215-9692; Onalan,
   Erhan/0000-0001-5395-0390; KULOGLU, TUNCAY/0000-0001-9874-3838
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NR 26
TC 1
Z9 1
U1 0
U2 4
PU VIA MEDICA
PI GDANSK
PA UL SWIETOKRZYSKA 73, 80-180 GDANSK, POLAND
SN 0423-104X
J9 ENDOKRYNOL POL
JI Endokrynol. Pol.
PY 2020
VL 71
IS 3
BP 249
EP 255
AR PMID 32293703
DI 10.5603/EP.a2020.0017
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA NE9WE
UT WOS:000562953800006
PM 32293703
OA gold
DA 2025-06-11
ER

PT J
AU Franco, ND
   Lubaczeuski, C
   Guizoni, DM
   Victorio, JA
   Santos-Silva, JC
   Brum, PC
   Carneiro, EM
   Davel, AP
AF Franco, Nathalia da Silva
   Lubaczeuski, Camila
   Guizoni, Daniele M.
   Victorio, Jamaira A.
   Santos-Silva, Junia C.
   Brum, Patricia C.
   Carneiro, Everardo M.
   Davel, Ana P.
TI Propranolol treatment lowers blood pressure, reduces vascular
   inflammatory markers and improves endothelial function in obese mice
SO PHARMACOLOGICAL RESEARCH
LA English
DT Article
DE Obesity; Endothelial dysfunction; Hypertension; Insulin resistance;
   beta-adrenergic blockade; Inflammatory markers
ID NITRIC-OXIDE SYNTHASE; DIET-INDUCED OBESITY; HIGH-FAT DIET; NF-KAPPA-B;
   INSULIN-STIMULATED PRODUCTION; LEFT-VENTRICULAR HYPERTROPHY;
   SYMPATHETIC-NERVOUS-SYSTEM; AORTIC SMOOTH-MUSCLE; OXIDATIVE STRESS;
   METABOLIC SYNDROME
AB Obesity-associated hypertension is accompanied by a number of cardiovascular risk factors including vascular insulin resistance (IR) and higher sympathetic nervous activity. Therefore, autonomic blockade was demonstrated to reverse hypertension, endothelial dysfunction and IR in obese individuals. We hypothesized that beta-AR blockade with propranolol would restore endothelial function and vascular insulin signaling in obesity, associated with an anti-inflammatory effect. Body weight, systolic blood pressure (SBP), plasma biochemical parameters and aortic endothelial function were analyzed in mice fed standard diet (control group) or a high fat diet (HFD) that were treated with vehicle (water) or propranolol (10 mg/kg/day) for 8 weeks. Propranolol treatment did not modify obesogenic effect of HFD feeding. However, propranolol was effective in preventing the rise in SBP, the hyperinsulinemia and the impaired endothelium-dependent relaxation to acetylcholine and to insulin in obese mice. Protective effect of propranolol administration in endothelial function was associated with increased nitric oxide (NO) production and phosphorylation of Akt (Ser473) and eNOS (Ser1177), but with reduced phosphoIRS-1(Ser307) and phospho-ERK1/2 (Thr202/Tyr204). In addition, (beta-blocker propranolol prevented the NF-kappa B nuclear translocation and the increase in phospho-I kappa B-alpha (Ser32) and in interleukin(IL)-6 expression in aorta of obese mice, without significant changes in either aortic reactive oxygen species production or in circulating IL-6 and TNF-alpha levels. In beta(2)-AR knockout mice, despite increasing body weight and visceral fat, HFD did not increase SBP and showed a partial improvement of endothelial function, revealing a role of (beta(2)-AR in cardiovascular effects of obesity. In conclusion, our results suggest that beta-AR blockade with propranolol is effective to prevent the endothelial dysfunction, vascular IR and pro-inflammatory state displayed in HFD-induced obesity, independent of changes in body weight. (C) 2017 Elsevier Ltd. All rights reserved.
C1 [Franco, Nathalia da Silva; Lubaczeuski, Camila; Guizoni, Daniele M.; Victorio, Jamaira A.; Santos-Silva, Junia C.; Carneiro, Everardo M.; Davel, Ana P.] Univ Estadual Campinas, UNICAMP, Inst Biol, Dept Struct & Funct Biol, POB 6109, Campinas, SP, Brazil.
   [Brum, Patricia C.] Univ Sao Paulo, Sch Phys Educ & Sport, Sao Paulo, Brazil.
C3 Universidade de Sao Paulo; Universidade Estadual de Campinas;
   Universidade de Sao Paulo
RP Davel, AP (corresponding author), Univ Estadual Campinas, UNICAMP, Inst Biol, Dept Struct & Funct Biol, POB 6109, Campinas, SP, Brazil.
EM anadavel@unicamp.br
RI Silva, Junia/E-5052-2015; Carneiro, Everardo/D-4758-2012; Lubaczeuski,
   Camila/N-5226-2017; Victorio, Jamaira Aparecida/R-7049-2018; Davel,
   Ana/L-8801-2013; Brum, Patricia/E-6605-2011; Mendes Guizoni,
   Daniele/R-6974-2018
OI Lubaczeuski, Camila/0000-0001-6882-7686; Magalhaes Carneiro,
   Everardo/0000-0003-3212-369X; Victorio, Jamaira
   Aparecida/0000-0002-0686-5844; Davel, Ana/0000-0002-9862-4262; Brum,
   Patricia/0000-0002-4750-6506; Mendes Guizoni,
   Daniele/0000-0001-7317-6371
FU Sao Paulo Research Foundation - FAPESP [2014/07947-6, 2015/00074-0];
   Brazilian National Council for Scientific and Technological Development
   CNPq; Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
   [14/07947-6, 15/00074-0] Funding Source: FAPESP
FX This work was supported by the Sao Paulo Research Foundation - FAPESP
   (grant numbers 2014/07947-6 and 2015/00074-0). APD, PCB and EMC hold
   Research Fellowship from The Brazilian National Council for Scientific
   and Technological Development CNPq.
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NR 62
TC 17
Z9 18
U1 0
U2 24
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 1043-6618
J9 PHARMACOL RES
JI Pharmacol. Res.
PD AUG
PY 2017
VL 122
BP 35
EP 45
DI 10.1016/j.phrs.2017.05.018
PG 11
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA FC0YT
UT WOS:000406565300004
PM 28539257
DA 2025-06-11
ER

PT J
AU Panahi, Y
   Khalili, N
   Sahebi, E
   Namazi, S
   Reiner, Z
   Majeed, M
   Sahbekar, A
AF Panahi, Yunes
   Khalili, Nahid
   Sahebi, Ebrahim
   Namazi, Soha
   Reiner, Zeljko
   Majeed, Muhammed
   Sahbekar, Amirhossein
TI Curcuminoids modify lipid profile in type 2 diabetes mellitus: A
   randomized controlled trial
SO COMPLEMENTARY THERAPIES IN MEDICINE
LA English
DT Article
DE Curcumin; Diabetes; Cardiovascular disease; Cholesterol; Dyslipidemia;
   Lipoprotein(a)
ID PLASMA LIPOPROTEIN(A) CONCENTRATIONS; SYSTEMIC OXIDATIVE STRESS;
   EXTENDED-RELEASE NIACIN; FATTY LIVER-DISEASE; QUALITY-OF-LIFE; PIPERINE
   COMBINATION; CLINICAL-PRACTICE; SULFUR MUSTARD; METABOLIC SYNDROME;
   DOUBLE-BLIND
AB Bacicground: Type 2 diabetes (T2D) is an established risk factor for cardiovascular disease (CVD) and is associated with disturbed metabolism of lipids and lipoproteins. Curcuminoids are natural products with anti-diabetic and lipid-modifying actions but their efficacy in improving dyslipidemia in diabetic individuals has not been sufficiently studied.
   Objective: To investigate the efficacy of supplementation with curcuminoids, plus piperine as an absorption enhancer, in improving serum lipids in patients with T2D.
   Methods: In this 12-week randomized double-blind placebo-controlled trial, subjects with T2D (n = 118) were assigned to curcuminoids (1000 mg/day plus piperine 10 mg/day) or placebo plus standard of care for T2D. Serum concentrations of lipids including total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), lipoprotein(a) [Lp(a)], and non-HDL-C were determined at baseline and at the end of trial.
   Results: Between-group comparison of change in the study parameters revealed significant reductions in serum levels of TC (-21.86 +/- 25.78 versus -17.06 +/- 41.51, respectively; p = 0.023), non-HDL-C (-23.42 +/- 25.13 versus-16.84 +/- 41.42, respectively; p = 0.014) and Lp(a) (-1.50 +/- 1.61 versus -0.34 +/- 1.73, respectively; p = 0.001) and elevations in serum HDL-C levels (1.56 +/- 4.25 versus -0.22 +/- 4.62, respectively; p = 0.048) in the curcuminoids group as compared with the placebo group (p < 0.05). Serum TG and LDL-C changes did not show any significant difference between the study groups (p > 0.05).
   Conclusion: Curcuminoids supplementation can reduce serum levels of atherogenic lipid indices including nonHDL-C and Lp(a). Therefore, curcuminoids supplementation could contribute to a reduced risk of cardiovascular events in dyslipidemic patients with T2D.
C1 [Panahi, Yunes] Baqiyatallah Univ Med Sci, Chem Injuries Res Ctr, Tehran, Iran.
   [Khalili, Nahid] Univ Tehran Med Sci, Dept Endocrinol, Tehran, Iran.
   [Sahebi, Ebrahim; Namazi, Soha] Shiraz Univ Med Sci, Sch Pharm, Dept Pharmacotherapy, POB 1583, Shiraz, Iran.
   [Reiner, Zeljko] Univ Zagreb, Univ Hosp Ctr Zagreb, Dept Internal Med, Sch Med, Kispaticeva 12, Zagreb, Croatia.
   [Majeed, Muhammed] Sabinsa Corp, East Windsor, NJ USA.
   [Sahbekar, Amirhossein] Mashhad Univ Med Sci, Biotechnol Res Ctr, Mashhad, Iran.
C3 Baqiyatallah University of Medical Sciences (BMSU); Tehran University of
   Medical Sciences; Shiraz University of Medical Science; University of
   Zagreb; UNIVERSITY ZAGREB HOSPITAL; Mashhad University of Medical
   Sciences
RP Sahbekar, A (corresponding author), Mashhad Univ Med Sci, Sch Med, Dept Med Biotechnol, POB 91779-48564, Mashhad, Iran.
EM amir_saheb2000@yahoo.com
RI Khalili, Nahid/U-1226-2019; Sahebkar, Amirhossein/B-5124-2018; Popescu,
   Bogdan A./AAA-1319-2022
OI Panahi, Yunes/0000-0002-2504-8356
FU Clinical Trial Research Center (Tehran, Iran)
FX This study was financially supported by Clinical Trial Research Center
   (Tehran, Iran). The authors gratefully acknowledge Sami Labs LTD
   (Bangalore, India) for providing the drug material used in this trial.
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NR 52
TC 172
Z9 178
U1 3
U2 28
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0965-2299
EI 1873-6963
J9 COMPLEMENT THER MED
JI Complement. Ther. Med.
PD AUG
PY 2017
VL 33
BP 1
EP 5
DI 10.1016/j.ctim.2017.05.006
PG 5
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA FD4YI
UT WOS:000407537700001
PM 28735818
DA 2025-06-11
ER

PT J
AU Venter, C
   Oberholzer, HM
   Bester, J
   van Rooy, MJ
   Bester, MJ
AF Venter, Chantelle
   Oberholzer, Hester Magdalena
   Bester, Janette
   van Rooy, Mia-Jeanne
   Bester, Megan Jean
TI Ultrastructural, Confocal and Viscoelastic Characteristics of Whole
   Blood and Plasma After Exposure to Cadmium and Chromium Alone and in
   Combination: An Ex Vivo Study
SO CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
LA English
DT Article
DE Heavy metals; Cadmium; Chromium; Erythrocytes; Fibrin fibres; Platelets;
   Thromboelastography; Scanning electron microscopy; Confocal microscopy
ID SUICIDAL ERYTHROCYTE DEATH; TRANSIENT ISCHEMIC ATTACK; METABOLIC
   SYNDROME; OXIDATIVE STRESS; COAGULATION; ERYPTOSIS; SMOKING; MECHANISMS;
   THROMBOSIS; THROMBOELASTOGRAPHY
AB Background/Aims: Heavy metal pollution is increasing in the environment, contaminating water, food and air supplies. This can be linked to many anthropogenic activities. Heavy metals are absorbed through the skin, inhalation and/or orally. Irrespective of the manner of heavy metal entry in the body, the blood circulatory system is potentially the first to be affected following exposure and adverse effects on blood coagulation can lead to associated thrombotic disease. Although the plasma levels and the effects of cadmium (Cd) and chromium (Cr) on erythrocytes and lymphocytes have been described, the environmental exposure to heavy metals are not limited to a single metal and often involves metal mixtures, with each metal having different rates of absorption, different cellular, tissue, and organ targets. Therefore the aim of this study is to investigate the effects of the heavy metals Cd and Cr alone and whether Cr synergistically increases the effect of Cd on physiological important processes such as blood coagulation. Methods: Human blood was exposed to the heavy metals ex vivo, and thereafter morphological analysis was performed with scanning electron- and confocal laser scanning microscopy (CLSM) in conjunction with thromboelastography (R). Results: The erythrocytes, platelets and fibrin networks presented with ultrastructural changes, including varied erythrocytes morphologies, activated platelets and significantly thicker fibrin fibres in the metal-exposed groups. CLSM analysis revealed the presence of phosphatidylserine on the outer surface of the membranes of the spherocytic erythrocytes exposed to Cd and Cr alone and in combination. The viscoelastic analysis revealed only a trend that indicates that clots that will form after heavy metal exposure, will likely be fragile and unstable especially for Cd and Cr in combination. Conclusion: This study identified the blood as an important target system of Cd and Cr toxicity. (C) 2017 The Author(s) Published by S. Karger AG, Basel
C1 [Venter, Chantelle; Oberholzer, Hester Magdalena; Bester, Megan Jean] Univ Pretoria, Fac Hlth Sci, Dept Anat, Pretoria, South Africa.
   [Bester, Janette; van Rooy, Mia-Jeanne] Univ Pretoria, Dept Physiol, Fac Hlth Sci, Pretoria, South Africa.
C3 University of Pretoria; University of Pretoria
RP Oberholzer, HM (corresponding author), Univ Pretoria, Dept Anat, Fac Hlth Sci, Private Bag x323, ZA-0007 Arcadia, South Africa.
EM nanette.oberholzer@up.ac.za
RI Bester, Megan/AGR-1530-2022
OI Bester, Megan/0000-0003-1704-0052; Oberholzer,
   Nanette/0000-0002-5762-3765; van Rooy, Mia-Jeanne/0000-0003-1224-5147;
   Bester, Janette/0000-0002-8931-9194
FU National Research Foundation (NRF) [92768]
FX The authors would like to thank the National Research Foundation (NRF)
   for their financial support (Grant number: 92768). Staff of the
   Department of Physiology of the University of Pretoria that assisted
   with phlebotomy and TEG (R) analysis and all the volunteers that
   generously donated blood required for this study.
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NR 54
TC 15
Z9 17
U1 1
U2 9
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1015-8987
EI 1421-9778
J9 CELL PHYSIOL BIOCHEM
JI Cell. Physiol. Biochem.
PY 2017
VL 43
IS 3
BP 1288
EP 1300
DI 10.1159/000481841
PG 13
WC Cell Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Physiology
GA FN7TI
UT WOS:000416221300033
PM 28992628
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Charles, EF
   Lambert, CG
   Kerner, B
AF Charles, Ellen F.
   Lambert, Christophe G.
   Kerner, Berit
TI Bipolar disorder and diabetes mellitus: evidence for disease-modifying
   effects and treatment implications
SO INTERNATIONAL JOURNAL OF BIPOLAR DISORDERS
LA English
DT Review
DE Bipolar disorder; Diabetes; Epidemiology; Cohort studies;
   Pathophysiology; Evidence
ID SERIOUS MENTAL-ILLNESS; CARDIOVASCULAR RISK-FACTORS; MANIC-DEPRESSIVE
   PSYCHOSIS; GENERAL MEDICAL CONDITIONS; DRUG-NAIVE PATIENTS;
   INSULIN-RESISTANCE; PSYCHIATRIC-DISORDERS; METABOLIC SYNDROME; OXIDATIVE
   STRESS; BRAIN CHANGES
AB Background: Bipolar disorder refers to a group of chronic psychiatric disorders of mood and energy levels. While dramatic psychiatric symptoms dominate the acute phase of the diseases, the chronic course is often determined by an increasing burden of co-occurring medical conditions. High rates of diabetes mellitus in patients with bipolar disorder are particularly striking, yet unexplained. Treatment and lifestyle factors could play a significant role, and some studies also suggest shared pathophysiology and risk factors.
   Objective: In this systematic literature review, we explored data around the relationship between bipolar disorder and diabetes mellitus in recently published population-based cohort studies with special focus on the elderly.
   Methods: A systematic search in the PubMed database for the combined terms "bipolar disorder" AND "elderly" AND "diabetes" in papers published between January 2009 and December 2015 revealed 117 publications; 7 studies were large cohort studies, and therefore, were included in our review.
   Results: We found that age-and gender-adjusted risk for diabetes mellitus was increased in patients with bipolar disorder and vice versa (odds ratio range between 1.7 and 3.2).
   Discussion: Our results in large population-based cohort studies are consistent with the results of smaller studies and chart reviews. Even though it is likely that heterogeneous risk factors may play a role in diabetes mellitus and in bipolar disorder, growing evidence from cell culture experiments and animal studies suggests shared disease mechanisms. Furthermore, disease-modifying effects of bipolar disorder and diabetes mellitus on each other appear to be substantial, impacting both treatment response and outcomes.
   Conclusions: The risk of diabetes mellitus in patients with bipolar disorder is increased. Our findings add to the growing literature on this topic. Increasing evidence for shared disease mechanisms suggests new disease models that could explain the results of our study. A better understanding of the complex relationship between bipolar disorder and diabetes mellitus could lead to novel therapeutic approaches and improved outcomes.
C1 [Charles, Ellen F.] Univ Calif Los Angeles, David Geffen Sch Med, 10833 Le Conte Ave, Los Angeles, CA 90095 USA.
   [Lambert, Christophe G.] Univ New Mexico, Ctr Global Hlth, Div Translat Informat, Dept Internal Med,Hlth Sci Ctr,MSC10 5550, Albuquerque, NM 87131 USA.
   [Kerner, Berit] Univ Calif Los Angeles, Semel Inst Neurosci & Human Behav, 695 Charles E Young Dr South,Box 951761, Los Angeles, CA 90095 USA.
   [Kerner, Berit] Private Univ Witten Herdecke, Fak Gesundheit, Alfred Herrhausen Str 50, D-58448 Witten, Germany.
C3 University of California System; University of California Los Angeles;
   University of California Los Angeles Medical Center; David Geffen School
   of Medicine at UCLA; University of New Mexico; University of New
   Mexico's Health Sciences Center; University of California System;
   University of California Los Angeles; Witten Herdecke University
RP Kerner, B (corresponding author), Univ Calif Los Angeles, Semel Inst Neurosci & Human Behav, 695 Charles E Young Dr South,Box 951761, Los Angeles, CA 90095 USA.; Kerner, B (corresponding author), Private Univ Witten Herdecke, Fak Gesundheit, Alfred Herrhausen Str 50, D-58448 Witten, Germany.
EM Berit.Kerner@uni-wh.de
RI Lambert, Christophe/AAH-4448-2021
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NR 121
TC 41
Z9 46
U1 2
U2 22
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 2194-7511
J9 INT J BIPOLAR DISORD
JI INT. J. BIBPOLAR DISORD.
PD JUL 7
PY 2016
VL 4
AR 13
DI 10.1186/s40345-016-0054-4
PG 11
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychiatry
GA DR1QS
UT WOS:000379680600001
PM 27389787
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Kandadi, MR
   Panzhinskiy, E
   Roe, ND
   Nair, S
   Hu, DH
   Sun, AJ
AF Kandadi, Machender R.
   Panzhinskiy, Eygeniy
   Roe, Nathan D.
   Nair, Sreejayan
   Hu, Dahai
   Sun, Aijun
TI Deletion of protein tyrosine phosphatase 1B rescues against myocardial
   anomalies in high fat diet-induced obesity: Role of AMPK-dependent
   autophagy
SO BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
LA English
DT Article
DE PTP1B; High fat diet; Cardiac; Contraction; Autophagy
ID CARDIAC CONTRACTILE DYSFUNCTION; LIVER-SPECIFIC DELETION;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; METABOLIC SYNDROME; HEART-FAILURE;
   NEURONS LEADS; BODY-WEIGHT; PTP1B; HYPERTROPHY
AB Obesity-induced cardiomyopathy may be mediated by alterations in multiple signaling cascades involved in glucose and lipid metabolism. Protein tyrosine phosphatase-1B (PTP1B) is an important negative regulator of insulin signaling. This study was designed to evaluate the role of PTP1B in high fat diet-induced cardiac contractile anomalies. Wild-type and PTP1B knockout mice were fed normal (10%) or high (45%) fat diet for 5 months prior to evaluation of cardiac function. Myocardial function was assessed using echocardiography and an lon-Optix MyoCam system. Western blot analysis was employed to evaluate levels of AMPK, mTOR, raptor, Beclin-1, p62 and LC3-II. RT-PCR technique was employed to assess genes involved in hypertrophy and lipid metabolism. Our data revealed increased LV thickness and LV chamber size as well as decreased fractional shortening following high fat diet intake, the effect was nullified by PTP1B knockout. High fat diet intake compromised cardiomyocyte contractile function as evidenced by decreased peak shortening, maximal velocity of shortening/ relengthening, intracellular Ca2+ release as well as prolonged duration of relengthening and intracellular Ca2+ decay, the effects of which were alleviated by PTP1B knockout. High fat diet resulted in enlarged cardiomyocyte area and increased lipid accumulation, which were attenuated by PTP1B knockout. High fat diet intake dampened myocardial autophagy as evidenced by decreased LC3-II conversion and Bedin-1, increased p62 levels as well as decreased phosphorylation of AMPK and raptor, the effects of which were significantly alleviated by PTP1B knockout. Pharmacological inhibition of AMPK using compound C disengaged PTP1B knockout-conferred protection against fatty acid-induced cardiomyocyte contractile anomalies. Taken together, our results suggest that PTP1B knockout offers cardioprotection against high fat diet intake through activation of AMPK. This article is part of a Special Issue entitled: Autophagy and protein quality control in cardiometabolic diseases. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Kandadi, Machender R.; Panzhinskiy, Eygeniy; Roe, Nathan D.; Nair, Sreejayan; Sun, Aijun] Univ Wyoming, Coll Hlth Sci, Ctr Cardiovasc Res & Alternat Med, Laramie, WY 82071 USA.
   [Hu, Dahai] Fourth Mil Med Univ, Xijing Hosp, Dept Bum & Cutaneous Surg, Xian 710032, Peoples R China.
   [Sun, Aijun] Fudan Univ, Zhongshan Hosp, Shanghai Inst Cardiovasc Dis, Shanghai 200032, Peoples R China.
   [Sun, Aijun] Fudan Univ, Inst Biomed Sci, Shanghai 200032, Peoples R China.
C3 University of Wyoming; Air Force Medical University; Fudan University;
   Fudan University
RP Hu, DH (corresponding author), Fourth Mil Med Univ, Xijing Hosp, Dept Bum & Cutaneous Surg, Xian 710032, Peoples R China.
EM hudhai@fmmu.edu.cn; sun.aijun@zs-hospital.sh.cn
RI yang, xuekang/IUP-2564-2023; Kandadi, Machender/E-4691-2010
FU NIH [P20 GM103432, P20 RR016474]; program for New Century Excellent
   Talents [NCET-12-0125]
FX This work was supported in part by NIH P20 GM103432, NIH P20 RR016474,
   and program for New Century Excellent Talents (NCET-12-0125).
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NR 61
TC 44
Z9 46
U1 0
U2 15
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0925-4439
EI 1879-260X
J9 BBA-MOL BASIS DIS
JI Biochim. Biophys. Acta-Mol. Basis Dis.
PD FEB
PY 2015
VL 1852
IS 2
SI SI
BP 299
EP 309
DI 10.1016/j.bbadis.2014.07.004
PG 11
WC Biochemistry & Molecular Biology; Biophysics; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Cell Biology
GA CA5QR
UT WOS:000348963400014
PM 25018087
OA Bronze
DA 2025-06-11
ER

PT J
AU Abu-Farha, M
   Tiss, A
   Abubaker, J
   Khadir, A
   Al-Ghimlas, F
   Al-Khairi, I
   Baturcam, E
   Cherian, P
   Elkum, N
   Hammad, M
   John, J
   Kavalakatt, S
   Warsame, S
   Behbehani, K
   Dermime, S
   Dehbi, M
AF Abu-Farha, Mohamed
   Tiss, Ali
   Abubaker, Jehad
   Khadir, Abdelkrim
   Al-Ghimlas, Fahad
   Al-Khairi, Irina
   Baturcam, Engin
   Cherian, Preethi
   Elkum, Naser
   Hammad, Maha
   John, Jeena
   Kavalakatt, Sina
   Warsame, Samia
   Behbehani, Kazem
   Dermime, Said
   Dehbi, Mohammed
TI Proteomics Analysis of Human Obesity Reveals the Epigenetic Factor HDAC4
   as a Potential Target for Obesity
SO PLOS ONE
LA English
DT Article
ID ENDOPLASMIC-RETICULUM STRESS; IIA HISTONE DEACETYLASES; NF-KAPPA-B;
   INSULIN-RESISTANCE; ADIPOSE-TISSUE; METABOLIC SYNDROME; GENE-EXPRESSION;
   UP-REGULATION; LYSINE ACETYLATION; SKELETAL-MUSCLE
AB Sedentary lifestyle and excessive energy intake are prominent contributors to obesity; a major risk factors for the development of insulin resistance, type 2 diabetes and cardiovascular diseases. Elucidating the molecular mechanisms underlying these chronic conditions is of relevant importance as it might lead to the identification of novel anti-obesity targets. The purpose of the current study is to investigate differentially expressed proteins between lean and obese subjects through a shot-gun quantitative proteomics approach using peripheral blood mononuclear cells (PBMCs) extracts as well as potential modulation of those proteins by physical exercise. Using this approach, a total of 47 proteins showed at least 1.5 fold change between lean and obese subjects. In obese, the proteomic profiling before and after 3 months of physical exercise showed differential expression of 38 proteins. Thrombospondin 1 (TSP1) was among the proteins that were upregulated in obese subjects and then decreased by physical exercise. Conversely, the histone deacetylase 4 (HDAC4) was downregulated in obese subjects and then induced by physical exercise. The proteomic data was further validated by qRT-PCR, Western blot and immunohistochemistry in both PBMCs and adipose tissue. We also showed that HDAC4 levels correlated positively with maximum oxygen consumption (V-O2 (Max)) but negatively with body mass index, percent body fat, and the inflammatory chemokine RANTES. In functional assays, our data indicated that ectopic expression of HDAC4 significantly impaired TNF-alpha-dependent activation of NF-kappa B, establishing thus a link between HDAC4 and regulation of the immune system. Together, the expression pattern of HDAC4 in obese subjects before and after physical exercise, its correlation with various physical, clinical and metabolic parameters along with its inhibitory effect on NF-kappa B are suggestive of a protective role of HDAC4 against obesity. HDAC4 could therefore represent a potential therapeutic target for the control and management of obesity and presumably insulin resistance.
C1 [Abu-Farha, Mohamed; Tiss, Ali; Abubaker, Jehad; Khadir, Abdelkrim; Al-Khairi, Irina; Baturcam, Engin; Cherian, Preethi; Hammad, Maha; John, Jeena; Kavalakatt, Sina; Warsame, Samia; Behbehani, Kazem; Dehbi, Mohammed] Dasman Diabet Inst, Dept Biomed Res, Kuwait, Kuwait.
   [Al-Ghimlas, Fahad; Behbehani, Kazem] Dasman Diabet Inst, Fitness & Rehabil Ctr, Kuwait, Kuwait.
   [Elkum, Naser; Behbehani, Kazem] Dasman Diabet Inst, Dept Biostat & Epidemiol, Kuwait, Kuwait.
   [Dermime, Said] King Fahad Specialist Hosp Dammam, Biomed Res Facil, Dammam, Saudi Arabia.
   [Dehbi, Mohammed] Qatar Biomed Res Inst, Genom Med & Syst Biol Res Ctr, Doha, Qatar.
C3 Dasman Diabetes Institute (DDI); Dasman Diabetes Institute (DDI); Dasman
   Diabetes Institute (DDI); Qatar Foundation (QF); Hamad Bin Khalifa
   University-Qatar; Qatar Biomedical Research Institute (QBRI)
RP Dehbi, M (corresponding author), Dasman Diabet Inst, Dept Biomed Res, Kuwait, Kuwait.
EM mdehbi@qf.org.qa
RI Elkum, Naser/AAU-5555-2020; Dermime, Said/P-2448-2019; Hammad,
   Maha/JVN-0750-2024; Abu-Farha, Mohamed/KHW-8579-2024; Abubaker,
   Jehad/KHV-9373-2024; Tiss, Ali/L-6656-2019
OI Hammad, Maha/0000-0002-8974-8255; Elkum, Naser/0000-0002-0457-0444;
   Abubaker, Jehad/0000-0003-0681-7305; Cherian,
   Preethi/0000-0002-2132-3533; Tiss, Ali/0000-0002-3024-5370; kavalakatt,
   sina/0000-0003-3795-1881; Abu-Farha, Mohamed/0000-0001-8357-1252
FU Kuwait Foundation for the Advancement of Sciences [RA-2010-003]
FX This work was supported by the Kuwait Foundation for the Advancement of
   Sciences under project (RA-2010-003). The funders had no role in study
   design, data collection and analysis, decision to publish, or
   preparation of the manuscript.
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NR 67
TC 77
Z9 84
U1 0
U2 24
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD SEP 24
PY 2013
VL 8
IS 9
AR e75342
DI 10.1371/journal.pone.0075342
PG 17
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 226HG
UT WOS:000325025200040
PM 24086512
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Farvid, MS
   Homayouni, F
   Kashkalani, F
   Shirzadeh, L
   Valipour, G
   Farahnak, Z
AF Farvid, M. S.
   Homayouni, F.
   Kashkalani, F.
   Shirzadeh, L.
   Valipour, G.
   Farahnak, Z.
TI The associations between oxygen radical absorbance capacity of dietary
   intake and hypertension in type 2 diabetic patients
SO JOURNAL OF HUMAN HYPERTENSION
LA English
DT Article
DE type 2 diabetic patients; antioxidant; ORAC; blood pressure
ID TOTAL ANTIOXIDANT CAPACITY; REDUCES BLOOD-PRESSURE; MEDITERRANEAN DIET;
   OXIDATIVE STRESS; DASH DIET; METABOLIC SYNDROME; HEALTHY-ADULTS;
   VITAMIN-C; ADHERENCE; ATTICA
AB The objective of this strudy was to investigate the potential associations between oxygen radical absorbance capacity (ORAC) of fruits, vegetables, legumes and nuts, and blood pressure in type 2 diabetic patients in Tehran. In a cross-sectional study of 506 type 2 diabetic patients, aged 28-75 years, usual dietary intakes were assessed by means of a 168-item food-frequency questionnaire. To calculate the estimated hydrophilic-ORAC, total ORAC, and total phenolics (TP) of fruits, vegetables, legumes and nuts for each participant, we used the United States Department of Agriculture Database for ORAC. We examined the associations between total ORAC and TP scores, and hypertension using logistic regression. After adjustment for potential confounders, a higher total ORAC score was associated with lower risk of hypertension. The odds ratios (ORs) of systolic blood pressure (SBP) > 140mmHg across increasing quartiles of the total ORAC score were 1.0, 0.71, 0.38 and 0.56 (P for trend = 0.016). The ORs of diastolic blood pressure (DBP) >90mmHg across increasing quartiles of the total ORAC score were 1.0, 0.59, 0.47 and 0.35 (P for trend = 0.008). Further adjustment for energy, protein and sodium intakes slightly strengthened these associations. Multivariate ORs of elevated SBP across quartiles of TP score were 1.0, 0.83, 0.41 and 0.63 (P for trend = 0.027), and for elevated DBP were 1.0, 0.50, 0.40 and 0.38 (P for trend = 0.006). Further adjustment for energy, protein and sodium intakes did not change the results materially. Our findings suggest that total antioxidant capacity of the dietary intake was negatively associated with hypertension in type 2 diabetic patients. Journal of Human Hypertension (2013) 27, 164-168; doi: 10.1038/jhh.2012.19; published online 14 June 2012
C1 [Farvid, M. S.; Homayouni, F.; Kashkalani, F.; Shirzadeh, L.; Valipour, G.; Farahnak, Z.] Shahid Beheshti Univ Med Sci, Dept Community Nutr, Natl Nutr & Food Technol Res Inst, Fac Nutr Sci & Food Technol, Tehran 193954741, Iran.
C3 Shahid Beheshti University Medical Sciences
RP Farvid, MS (corresponding author), Shahid Beheshti Univ Med Sci, Dept Community Nutr, Natl Nutr & Food Technol Res Inst, Fac Nutr Sci & Food Technol, Tehran 193954741, Iran.
EM m_farvid@sbmu.ac.ir
RI Farahnak, Zahra/ABB-7885-2020; f, m/AAM-2063-2021
OI Farvid, Maryam/0000-0003-1783-4186
FU National Nutrition and Food Technology Research Institute
FX This work was supported by a grant from National Nutrition and Food
   Technology Research Institute. We are indebted to the patients for their
   cooperation. MSF designed research data, did statistical analysis, and
   wrote the manuscript. FH, FK, LSH, GHV and ZF did data collection.
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NR 39
TC 8
Z9 8
U1 0
U2 9
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0950-9240
EI 1476-5527
J9 J HUM HYPERTENS
JI J. Hum. Hypertens.
PD MAR
PY 2013
VL 27
IS 3
BP 164
EP 168
DI 10.1038/jhh.2012.19
PG 5
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 119SI
UT WOS:000317117500004
PM 22695939
DA 2025-06-11
ER

PT J
AU Porro, C
   Benameur, T
   Cianciulli, A
   Vacca, M
   Chiarini, M
   De Angelis, M
   Panaro, MA
AF Porro, Chiara
   Benameur, Tarek
   Cianciulli, Antonia
   Vacca, Mirco
   Chiarini, Margherita
   De Angelis, Maria
   Panaro, Maria Antonietta
TI Functional and Therapeutic Potential of Cynara scolymus in Health
   Benefits
SO NUTRIENTS
LA English
DT Review
DE artichoke; inflammation; functional food; polyphenols
ID ARTICHOKE LEAF EXTRACT; DOUBLE-BLIND; METABOLIC SYNDROME;
   PHENOLIC-COMPOUNDS; BOWEL-DISEASE; L.; SUPPLEMENTATION; CHOLESTEROL;
   NEUROINFLAMMATION; TCF7L2-RS7903146
AB Dietary supplements enriched with bioactive compounds represent a promising approach to influence physiological processes and enhance longevity and overall health. Cynara cardunculus var. scolymus serves as a functional food supplement with a high concentration of bioactive compounds, which offers various health-promoting benefits. Several chronic diseases have metabolic, genetic, or inflammatory origins, which are frequently interconnected. Pharmacological treatments, although effective, often result in undesirable side effects. In this context, preventive approaches are gaining increased attention. Recent literature indicates that the consumption of bioactive compounds in the diet can positively influence the organism's biological functions. Polyphenols, well-known for their health benefits, are widely recognized as valuable compounds in preventing/combating various pathologies related to lifestyle, metabolism, and aging. The C. scolymus belonging to the Asteraceae family, is widely used in the food and herbal medicine fields for its beneficial properties. Although the inflorescences (capitula) of the artichoke are used for food and culinary purposes, preparations based on artichoke leaves can be used as an active ingredient in herbal medicines. Cynara scolymus shows potential benefits in different domains. Its nutritional value and health benefits make it a promising candidate for improving overall well-being. C. scolymus exhibits anti-inflammatory, antioxidant, liver-protective, bile-expelling, antimicrobial, and lipid-lowering neuroprotective properties. Different studies demonstrate that oxidative stress is the leading cause of the onset and progression of major human health disorders such as cardiovascular, neurological, metabolic, and cancer diseases. The large amount of polyphenol found in C. scolymus has an antioxidant activity, enabling it to neutralize free radicals, preventing cellular damage. This reduces the subsequent risk of developing conditions such as cancer, diabetes, and cardiovascular diseases. Additionally, these polyphenols demonstrate anti-inflammatory activity, which is closely associated with their antioxidant properties. As a result, C. scolymus has the potential to contribute to the treatment of chronic diseases, including intestinal disorders, cardiovascular diseases, and neurodegenerative pathologies. The current review discussed the nutritional profiles, potential benefits, and pharmacological effects of C. scolymus.
C1 [Porro, Chiara] Univ Foggia, Dept Clin & Expt Med, I-71122 Foggia, Italy.
   [Benameur, Tarek] King Faisal Univ, Coll Med, Dept Biomed Sci, Al Hasa 31982, Saudi Arabia.
   [Cianciulli, Antonia; Panaro, Maria Antonietta] Univ Bari, Dept Biosci Biotechnol & Environm, I-70125 Bari, Italy.
   [Vacca, Mirco; Chiarini, Margherita; De Angelis, Maria] Univ Bari Aldo Moro, Dept Soil Plant & Food Sci, I-70125 Bari, Italy.
C3 University of Foggia; King Faisal University; Universita degli Studi di
   Bari Aldo Moro; Universita degli Studi di Bari Aldo Moro
RP Panaro, MA (corresponding author), Univ Bari, Dept Biosci Biotechnol & Environm, I-70125 Bari, Italy.
EM chiara.porro@unifg.it; tbenameur@kfu.edu.sa;
   antonia.cianciulli@uniba.it; mirco.vacca@uniba.it;
   maria.deangelis@uniba.it; mariaantonietta.panaro@uniba.it
RI De Angelis, Maria/AAA-9909-2019; BENAMEUR, T/KIH-8629-2024; Panaro,
   Maria/AFS-7875-2022; Cianciulli, Antonia/GWQ-3185-2022; PORRO,
   CHIARA/G-7849-2018; Vacca, Mirco/AAU-6490-2021
OI Panaro, Maria Antonietta/0000-0001-5457-1069; De Angelis,
   Maria/0000-0002-2010-884X; PORRO, CHIARA/0000-0002-7526-6968; Vacca,
   Mirco/0000-0003-0813-169X
FU European Union-NextGenerationEU
FX No Statement Available
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NR 143
TC 9
Z9 9
U1 9
U2 14
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD MAR
PY 2024
VL 16
IS 6
AR 872
DI 10.3390/nu16060872
PG 24
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA MK2Z0
UT WOS:001193462200001
PM 38542782
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Zhang, PW
   Chen, K
   He, TP
   Guo, HH
   Chen, X
AF Zhang, Peiwen
   Chen, Ke
   He, Taiping
   Guo, Honghui
   Chen, Xu
TI Coenzyme Q10 supplementation improves adipokine profile in dyslipidemic
   individuals: a randomized controlled trial
SO NUTRITION & METABOLISM
LA English
DT Article
DE Coenzyme Q10; Adipokine; Dyslipidemia; Clinical trial; Dietary
   supplement; Mediating effect
ID METABOLIC SYNDROME; OXIDATIVE STRESS; DOUBLE-BLIND; RESISTIN;
   ADIPONECTIN; Q(10); INFLAMMATION; INSULIN; GLUCOSE; METAANALYSIS
AB Background: In previous study, we found that coenzyme Q10 (CoQ10) improved glucolipid profile in dyslipidemic individuals, but the mechanism is not yet clear. Adipokines have been demonstrated to be vital targets of metabolic diseases. The hypothesis that adipokines mediate the association of CoQ10 on glucolipid metabolism needs to be further studied in human.
   Methods: In this randomized, double-blinded, placebo-controlled trial, 101 dyslipidemic individuals were administrated to 120 mg CoQ10 or placebo for 24 weeks. Anthropometric parameters, glucolipid profile, serum total adiponectin, leptin, and resistin were evaluated at baseline, week 12 and week 24.
   Results: CoQ10 treatment significantly increased serum adiponectin levels at week 12 (165 [0, 362] ng/mL, p < 0.001) and at week 24 (523 [0, 1056] ng/mL,p<0.001]), which was significant different compared with placebo (p < 0.001). The increase of adiponectin was negative associated with decrease in index of homeostasis model assessment of insulin resistance (HOMA IR, r= 0.465, p= 0.001), triglyceride (TG, r= -0.297, p= 0.047), and low-density lipoprotein cholesterol (LDL-c, r = -0.440,p= 0.002) at week 24 only in CoQ10-treated group. Resistin was reduced by CoQ10 only at week 24 (- 1.19 [-4.35, 0.00] ng/mL, p < 0.001), which was significant different compared with placebo (p < 0.001). Reduction of resistin was positively correlated with the change in HOMA-IR (r= 0.343, p = 0.021) and TG (r =0.323, p = 0.030) at week 24 in CoQ10-treated group but not placebo group. Leptin was not influenced by CoQ10 treatment. Mediation analysis indicated that the improvement of HOMA-IR, TG and LDL-c by CoQ10 was mediated by adiponectin but not resistin.
   Conclusions: Our study shows that CoQ10 ameliorates glucolipid profile and adipokines dysfunction in dyslipidemic patients in 24 weeks' intervention. The beneficial effect of CoQ10 on glucolipid profile was mediated by adiponectin.
C1 [Zhang, Peiwen; He, Taiping; Guo, Honghui; Chen, Xu] Guangdong Med Univ, Sch Publ Hlth, Dept Nutr, Dongguan, Peoples R China.
   [Zhang, Peiwen; He, Taiping; Guo, Honghui] Guangdong Med Univ, Sch Publ Hlth, Dongguan Key Lab Environm Med, Dongguan, Peoples R China.
   [Chen, Ke; Chen, Xu] Sun Yat Sen Univ, Sch Publ Hlth, Dept Nutr, Guangzhou, Peoples R China.
C3 Guangdong Medical University; Guangdong Medical University; Sun Yat Sen
   University
RP Guo, HH; Chen, X (corresponding author), Guangdong Med Univ, Sch Publ Hlth, Dept Nutr, Dongguan, Peoples R China.; Guo, HH (corresponding author), Guangdong Med Univ, Sch Publ Hlth, Dongguan Key Lab Environm Med, Dongguan, Peoples R China.; Chen, X (corresponding author), Sun Yat Sen Univ, Sch Publ Hlth, Dept Nutr, Guangzhou, Peoples R China.
EM guohh1999@hotmail.com; chenx93@mail.sysu.edu.cn
RI Chen, Xu/KMX-8502-2024; Guo, Honghui/J-6355-2014
OI Chen, Xu/0000-0002-0545-3936
FU GuangDong Basic and Applied Basic Research Foundation [2020A1515111148];
   Discipline construction project of Guangdong Medical University
   [4SG21016G]; Young Innovative Talents Projects of Universities in
   Guangdong [2018KQNCX097]; Guangdong Medical University Research Startup
   Foundation [B2019005]
FX This work was supported by funding from GuangDong Basic and Applied
   Basic Research Foundation (2020A1515111148), Discipline construction
   project of Guangdong Medical University (4SG21016G), Young Innovative
   Talents Projects of Universities in Guangdong (2018KQNCX097), Guangdong
   Medical University Research Startup Foundation (B2019005).
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NR 44
TC 4
Z9 4
U1 0
U2 2
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1743-7075
J9 NUTR METAB
JI Nutr. Metab.
PD MAR 3
PY 2022
VL 19
IS 1
AR 13
DI 10.1186/s12986-022-00649-5
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA ZM0FD
UT WOS:000764041800003
PM 35241098
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Quarta, S
   Scoditti, E
   Carluccio, MA
   Calabriso, N
   Santarpino, G
   Damiano, F
   Siculella, L
   Wabitsch, M
   Verri, T
   Favari, C
   Del Rio, D
   Mena, P
   De Caterina, R
   Massaro, M
AF Quarta, Stefano
   Scoditti, Egeria
   Carluccio, Maria Annunziata
   Calabriso, Nadia
   Santarpino, Giuseppe
   Damiano, Fabrizio
   Siculella, Luisa
   Wabitsch, Martin
   Verri, Tiziano
   Favari, Claudia
   Del Rio, Daniele
   Mena, Pedro
   De Caterina, Raffaele
   Massaro, Marika
TI Coffee Bioactive N-Methylpyridinium Attenuates Tumor Necrosis
   Factor (TNF)-α-Mediated Insulin Resistance and Inflammation in Human
   Adipocytes
SO BIOMOLECULES
LA English
DT Article
DE coffee bioactives; N-methylpyridinium; adipocytes; inflammation; insulin
   resistance
ID PROLIFERATOR-ACTIVATED RECEPTORS; ADIPOSE TRIGLYCERIDE LIPASE;
   TNF-ALPHA; IN-VITRO; 3T3-L1 ADIPOCYTES; OXIDATIVE STRESS; TERMINAL
   KINASE; OBESITY; EXPRESSION; TISSUE
AB Although coffee consumption has been historically associated with negative health outcomes, recent evidence suggests a lower risk of metabolic syndrome, obesity and diabetes among regular coffee drinkers. Among the plethora of minor organic compounds assessed as potential mediators of coffee health benefits, trigonelline and its pyrolysis product N-methylpyridinium (NMP) were preliminary shown to promote glucose uptake and exert anti-adipogenic properties. Against this background, we aimed at characterizing the effects of trigonelline and NMP in inflamed and dysfunctional human adipocytes. Human Simpson-Golabi-Behmel syndrome (SGBS) adipocytes were treated with NMP or, for comparison, trigonelline, for 5 h before stimulation with tumor necrosis factor (TNF)-alpha. NMP at concentrations as low as 1 mu mol/L reduced the stimulated expression of several pro-inflammatory mediators, including C-C Motif chemokine ligand (CCL)-2, C-X-C Motif chemokine ligand (CXCL)-10, and intercellular adhesion Molecule (ICAM)-1, but left the induction of prostaglandin G/H synthase (PTGS)2, interleukin (IL)-1 beta, and colony stimulating factor (CSF)1 unaffected. Furthermore, NMP restored the downregulated expression of adiponectin (ADIPOQ). These effects were functionally associated with downregulation of the adhesion of monocytes to inflamed adipocytes. Under the same conditions, NMP also reversed the TNF-alpha-mediated suppression of insulin-stimulated Ser473 Akt phosphorylation and attenuated the induction of TNF-alpha-stimulated lipolysis restoring cell fat content. In an attempt to preliminarily explore the underlying mechanisms of its action, we show that NMP restores the expression of the master regulator of adipocyte differentiation peroxisome proliferator-activated receptor (PPAR)gamma and downregulates activation of the pro-inflammatory mitogen-activated protein jun N-terminal kinase (JNK). In conclusion, NMP reduces adipose dysfunction in pro-inflammatory activated adipocytes. These data suggest that bioactive NMP in coffee may improve the inflammatory and dysmetabolic milieu associated with obesity.
C1 [Quarta, Stefano; Damiano, Fabrizio; Siculella, Luisa; Verri, Tiziano] Univ Salento, Dept Biol & Environm Sci & Technol DISTEBA, I-73100 Lecce, Italy.
   [Scoditti, Egeria; Carluccio, Maria Annunziata; Calabriso, Nadia; Massaro, Marika] Natl Res Council CNR, Inst Clin Physiol IFC, I-73100 Lecce, Italy.
   [Santarpino, Giuseppe] Paracelsus Med Univ, Cardiovasc Ctr, D-90471 Nurnberg, Germany.
   [Santarpino, Giuseppe] Citta di Lecce Hosp, GVM Care & Res, I-73100 Lecce, Italy.
   [Santarpino, Giuseppe] Magna Graecia Univ Catanzaro, Dept Expt & Clin Med, Cardiac Surg Unit, I-88100 Catanzaro, Italy.
   [Wabitsch, Martin] Univ Ulm, Dept Pediat & Adolescent Med, Div Pediat Endocrinol Diabet & Obes, D-89075 Ulm, Germany.
   [Favari, Claudia; Del Rio, Daniele; Mena, Pedro] Univ Parma, Dept Food & Drugs, Human Nutr Unit, I-43125 Parma, Italy.
   [De Caterina, Raffaele] Pisa Univ Hosp, Cardiol Div, I-56126 Pisa, Italy.
   [De Caterina, Raffaele] Fdn Villa Serena Ric, I-65013 Pescara, Italy.
C3 University of Salento; Consiglio Nazionale delle Ricerche (CNR);
   Istituto di Fisiologia Clinica (IFC-CNR); Magna Graecia University of
   Catanzaro; Ulm University; University of Parma; University of Pisa;
   Azienda Ospedaliero Universitaria Pisana
RP Massaro, M (corresponding author), Natl Res Council CNR, Inst Clin Physiol IFC, I-73100 Lecce, Italy.; De Caterina, R (corresponding author), Pisa Univ Hosp, Cardiol Div, I-56126 Pisa, Italy.; De Caterina, R (corresponding author), Fdn Villa Serena Ric, I-65013 Pescara, Italy.
EM stefano.quarta3@unisalento.it; egeria.scoditti@ifc.cnr.it;
   maria.carluccio@ifc.cnr.it; nadia.calabriso@ifc.cnr.it;
   gsantarpino@gymnet.it; fabrizio.damiano@unisalento.it;
   luisa.siculella@unisalento.it; Martin.Wabitsch@uniklinik-ulm.de;
   tiziano.verri@unisalento.it; daudia.favari@unipr.it;
   daniele.delrio@unipr.it; pedromiguel.menaparreno@unipr.it;
   raffaele.decaterina@unipi.it; marika.massaro@ifc.cnr.it
RI Damiano, Fabrizio/AAF-9594-2020; Carluccio, Maria/AAO-1683-2020; Mena,
   Pedro/P-6353-2019; Quarta, Stefano/AAC-9033-2021; Massaro,
   Marika/HNI-1375-2023; De Caterina, Raffaele/K-3857-2016; Santarpino,
   Giuseppe/H-8678-2013; Del Rio, Daniele/E-8696-2010; SCODITTI,
   EGERIA/J-8609-2016; Verri, Tiziano/K-1442-2013
OI Del Rio, Daniele/0000-0001-5394-1259; Favari,
   Claudia/0000-0003-0669-2223; SCODITTI, EGERIA/0000-0003-2753-8487;
   Santarpino, Giuseppe/0000-0002-4913-9834; Verri,
   Tiziano/0000-0003-4983-2767; Damiano, Fabrizio/0000-0001-7828-9519;
   Massaro, Marika/0000-0001-6124-5077; Quarta, Stefano/0000-0003-1589-4177
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NR 81
TC 13
Z9 13
U1 0
U2 9
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2218-273X
J9 BIOMOLECULES
JI Biomolecules
PD OCT
PY 2021
VL 11
IS 10
AR 1545
DI 10.3390/biom11101545
PG 20
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA XI9RM
UT WOS:000726439000001
PM 34680177
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Zhang, B
   Liu, L
   Guo, L
   Guo, SG
   Zhao, XY
   Liu, GS
   Li, Q
   Jiang, LQ
   Pan, BL
   Nie, JS
   Yang, J
AF Zhang, Bin
   Liu, Lu
   Guo, Lan
   Guo, Shugang
   Zhao, Xinyu
   Liu, Gaisheng
   Li, Qiang
   Jiang, Liuquan
   Pan, Baolong
   Nie, Jisheng
   Yang, Jin
TI Telomere length mediates the association between polycyclic aromatic
   hydrocarbons exposure and abnormal glucose level among Chinese coke oven
   plant workers
SO CHEMOSPHERE
LA English
DT Article
DE Polycyclic aromatic hydrocarbons; Telomere length; Blood glucose;
   Mediating effects
ID OXIDATIVE DNA-DAMAGE; INSULIN-RESISTANCE; METABOLIC SYNDROME; INCREASED
   RISK; CANCER-RISK; STRESS; CARCINOGENS; PREVALENCE; BIOMARKERS; ADDUCTS
AB Introduction: Diabetes is a chronic and complex disease determined by environmental and genetic factors. This study aimed to investigate the association between polycyclic aromatic hydrocarbons (PAHs) exposure and fasting blood glucose levels and telomere length among coke-oven plant workers, to explore potential role of telomere length (TL) in the association between PAHs exposure and abnormal glucose level.
   Methods: The cross-sectional survey was conducted in 2017. The high-performance liquid chromatography mass spectrometry (HPLC-MS) was used to detect 11 urine biomarkers of PAHs exposure. TL was measured using the Real-time quantitative polymerase chain reaction (RT-qPCR) method. Logistic regression model, the modified Poisson regression models, and mediation analysis were used to evaluate the associations between PAHs exposure, TL, and abnormal glucose.
   Results: The results showed that the urinary 1-hydroxypyrene (1-PYR) was positively related to abnormal glucose in a dose-dependent manner (P trend = 0.007), the prevalence ratio of abnormal glucose was 8% (95% CI: 1.01e1.16) higher in 3rd tertile of urinary 1-PYR levels. Urinary 1-PYR in the 2nd tertile and 3rd tertile were associated with a 53% (OR = 0.47, 95% CI: 0.28-0.79) and 59% (OR = 0.41, 95% CI: 0.23-0.76) higher risk of shortening TL. And there was a negatively association between 1-PYR and TL in a dose-dependent manner (P trend = 0.045). We observed that the association between 1-PYR and abnormal glucose was more significantly positive among participants with median TL level (P-trend = 0.006). In addition, mediation analysis showed the TL could explain 11.7% of the effect of abnormal glucose related to PAHs exposure.
   Conclusions: Our findings suggested the effect of abnormal glucose related to PAHs exposure was mediated by telomere length in coke oven plant workers. (C) 2020 Elsevier Ltd. All rights reserved.
C1 [Zhang, Bin; Liu, Lu; Guo, Lan; Zhao, Xinyu; Nie, Jisheng; Yang, Jin] Shanxi Med Univ, Sch Publ Hlth, Dept Occupat Hlth, Taiyuan, Shanxi, Peoples R China.
   [Guo, Shugang] Shanxi Prov Ctr Dis Control & Prevent, Taiyuan, Shanxi, Peoples R China.
   [Liu, Gaisheng; Li, Qiang; Jiang, Liuquan] Xishan Coal Elect Grp Co Ltd, Ctr Occupat Dis Prevent, Taiyuan, Shanxi, Peoples R China.
   [Pan, Baolong] Taiyuan Iron & Steel Grp Co Ltd, Gen Hosp, Taiyuan, Shanxi, Peoples R China.
C3 Shanxi Medical University; Taiyuan Iron & Steel Group
RP Yang, J (corresponding author), Shanxi Med Univ, Sch Publ Hlth, Dept Occupat Hlth, Taiyuan, Shanxi, Peoples R China.
EM yang_jin@sxmu.edu.cn
RI Zhao, Xinyu/I-4198-2013
OI Nie, Jisheng/0000-0003-4351-2017
FU National Nature Science Foundation of China [81273041, 30901180]; Shanxi
   Scholarship Council of China [HGKY2019053]; Natural Science Foundation
   of Shanxi Province of China [201701D121146]
FX This work was supported by National Nature Science Foundation of China
   [No. 81273041 and 30901180], Research Project Supported by Shanxi
   Scholarship Council of China [No. HGKY2019053] and Natural Science
   Foundation of Shanxi Province of China [No. 201701D121146].
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NR 68
TC 19
Z9 20
U1 2
U2 44
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0045-6535
EI 1879-1298
J9 CHEMOSPHERE
JI Chemosphere
PD MAR
PY 2021
VL 266
AR 129111
DI 10.1016/j.chemosphere.2020.129111
PG 10
WC Environmental Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology
GA TL1OL
UT WOS:000674624300093
PM 33310362
DA 2025-06-11
ER

PT J
AU Martino, F
   Martino, E
   Versacci, P
   Niglio, T
   Zanoni, C
   Puddu, PE
AF Martino, Francesco
   Martino, Eliana
   Versacci, Paolo
   Niglio, Tarcisio
   Zanoni, Cristina
   Puddu, Paolo E.
TI Lifestyle and awareness of cholesterol blood levels among 29159
   community school children in Italy
SO NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
LA English
DT Article
DE Mediterranean diet adherence; Children; Total cholesterol; KidMed score;
   Outdoor activities; Watching television
ID INTIMA-MEDIA THICKNESS; DISEASE RISK-FACTORS; CALABRIAN SIERRAS
   COMMUNITY; PHYSICAL-ACTIVITY; CARDIORESPIRATORY FITNESS; OXIDATIVE
   STRESS; MEDITERRANEAN DIET; METABOLIC SYNDROME; CARDIOVASCULAR RISK;
   EARLY INCREASE
AB Background and aim: Lifestyle habits including indoor and outdoor activities among community school children, adherence to the Mediterranean diet and awareness about total cholesterol blood levels represent determinant factors in cardiovascular disease (CVD) prevention. The aim of this study was to analyze the relationship between adherence to the Mediterranean diet, total cholesterol blood levels, body composition and hours per day spent in in-house or outdoor among 29,159 Italian 6-14 years-old community school children (50% boys). The KidMed questionnaire, modified to handle missing information on olive oil consumption, was used to assess the adherence to the Mediterranean diet among participants.
   Methods and results: Associations between variables were tested according to 3 classes of the Mediterranean diet adherence score using analysis of variance. Participants with high adherence to Mediterranean diet were few (1%). Overall awareness of total cholesterol blood levels was low among children (4.5%), slightly higher among parents (26.2 and 24.1% in mothers and fathers, respectively). Among Mediterranean diet adherent children, BMI was significantly (p < 0.001) smaller than among the non-Mediterranean or intermediate adherent children as were the total hours spent per day watching television or playing with videogames (p < 0.001) whereas the hours/day in sport or outdoor activities were more (p < 0.001). These results were confirmed by multiple linear regression with KidMed scored 0 to 8 as dependent variable.
   Conclusion: Although awareness of total cholesterol blood levels and adherence to the Mediterranean diet are rare among community school children, only among these a healthier lifestyle was practiced with a tendency to lower CVD risks. These results are important as the first sized experience of this type in Italy. (C) 2019 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.
C1 [Martino, Francesco; Martino, Eliana; Versacci, Paolo; Zanoni, Cristina] Sapienza Univ Rome, Dept Pediat Gynecol & Obstet, I-00161 Rome, Italy.
   [Niglio, Tarcisio] Ist Super San Presidenza, Serv CCS, Viale Regina Elena 299, I-00161 Rome, Italy.
   [Puddu, Paolo E.] Sapienza Univ Rome, Dept Cardiovasc Resp Nephrol Anesthesiol & Geriat, Viale Policlin 155, I-00161 Rome, Italy.
   [Puddu, Paolo E.] UNICAEN, EA 4650, Signalisat Electrophysiol & Imagerie Les Ischemie, F-14000 Caen, France.
   [Puddu, Paolo E.] Assoc Cardiac Res, I-00198 Rome, Italy.
C3 Sapienza University Rome; Sapienza University Rome; Universite de Caen
   Normandie
RP Puddu, PE (corresponding author), Sapienza Univ Rome, Dept Cardiovasc Resp Nephrol Anesthesiol & Geriat, Viale Policlin 155, I-00161 Rome, Italy.
EM puddu.pe@gmail.com
RI Puddu, Paolo/G-6180-2012; Niglio, Tarcisio/K-2496-2018
OI VERSACCI, PAOLO/0000-0002-4484-4729; Niglio,
   Tarcisio/0000-0001-6555-2453; Martino, Francesco/0000-0002-0368-1994;
   Puddu, Paolo Emilio/0000-0002-6191-7838
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NR 43
TC 8
Z9 8
U1 1
U2 8
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0939-4753
EI 1590-3729
J9 NUTR METAB CARDIOVAS
JI Nutr. Metab. Carbiovasc. Dis.
PD AUG
PY 2019
VL 29
IS 8
BP 802
EP 807
DI 10.1016/j.numecd.2019.05.060
PG 6
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism; Nutrition
   & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism;
   Nutrition & Dietetics
GA IK3TS
UT WOS:000476511900005
PM 31248716
OA Green Published
DA 2025-06-11
ER

PT J
AU Prouteau, M
   Loewith, R
AF Prouteau, Manoel
   Loewith, Robbie
TI Regulation of Cellular Metabolism through Phase Separation of Enzymes
SO BIOMOLECULES
LA English
DT Review
DE phase separation; molecular condensates; protein filaments; metabolism;
   signalling
ID ACETYL-COA CARBOXYLASE; YEAST PYRUVATE-KINASE; SACCHAROMYCES-CEREVISIAE;
   CTP SYNTHASE; GLYCOLYTIC-ENZYMES; STRESS GRANULES; POLYMERIZATION;
   REORGANIZATION; TRANSITION; SYNTHETASE
AB Metabolism is the sum of the life-giving chemical processes that occur within a cell. Proper regulation of these processes is essential for all organisms to thrive and prosper. When external factors are too extreme, or if internal regulation is corrupted through genetic or epigenetic changes, metabolic homeostasis is no longer achievable and diseases such as metabolic syndrome or cancer, aging, and, ultimately, death ensue. Metabolic reactions are catalyzed by proteins, and the in vitro kinetic properties of these enzymes have been studied by biochemists for many decades. These efforts led to the appreciation that enzyme activities can be acutely regulated and that this regulation is critical to metabolic homeostasis. Regulation can be mediated through allosteric interactions with metabolites themselves or via post-translational modifications triggered by intracellular signal transduction pathways. More recently, enzyme regulation has attracted the attention of cell biologists who noticed that change in growth conditions often triggers the condensation of diffusely localized enzymes into one or more discrete foci, easily visible by light microscopy. This reorganization from a soluble to a condensed state is best described as a phase separation. As summarized in this review, stimulus-induced phase separation has now been observed for dozens of enzymes suggesting that this could represent a widespread mode of activity regulation, rather than, or in addition to, a storage form of temporarily superfluous enzymes. Building on our recent structure determination of TOROIDs (TORc1 Organized in Inhibited Domain), the condensate formed by the protein kinase Target Of Rapamycin Complex 1 (TORC1), we will highlight that the molecular organization of enzyme condensates can vary dramatically and that future work aimed at the structural characterization of enzyme condensates will be critical to understand how phase separation regulates enzyme activity and consequently metabolic homeostasis. This information may ultimately facilitate the design of strategies to target the assembly or disassembly of specific enzymes condensates as a therapeutic approach to restore metabolic homeostasis in certain diseases.
C1 [Prouteau, Manoel; Loewith, Robbie] Univ Geneva, Dept Mol Biol, 30 Quai Ernest Ansermet, CH-1211 Geneva, Switzerland.
   [Prouteau, Manoel; Loewith, Robbie] Univ Geneva, Inst Genet & Genom Geneva iGE3, 30 Quai Ernest Ansermet, CH-1211 Geneva, Switzerland.
   [Loewith, Robbie] Univ Geneva, Swiss Natl Ctr Competence Res NCCR Chem Biol, Sci 2,Room 3-308,30 Quai Ernest Ansermet, CH-1211 Geneva, Switzerland.
C3 University of Geneva; University of Geneva; University of Geneva
RP Loewith, R (corresponding author), Univ Geneva, Dept Mol Biol, 30 Quai Ernest Ansermet, CH-1211 Geneva, Switzerland.; Loewith, R (corresponding author), Univ Geneva, Inst Genet & Genom Geneva iGE3, 30 Quai Ernest Ansermet, CH-1211 Geneva, Switzerland.; Loewith, R (corresponding author), Univ Geneva, Swiss Natl Ctr Competence Res NCCR Chem Biol, Sci 2,Room 3-308,30 Quai Ernest Ansermet, CH-1211 Geneva, Switzerland.
EM manoel.prouteau@unige.ch; robbie.loewith@unige.ch
RI Loewith, Robbie/S-6289-2016
OI Loewith, Robbie/0000-0002-2482-603X
FU European Research Council (ERC TORCH) [614552]; European Research
   Council (ERC) [614552] Funding Source: European Research Council (ERC)
FX This research was funded by the European Research Council (ERC TORCH,
   grant number: 614552).
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NR 64
TC 67
Z9 72
U1 1
U2 31
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2218-273X
J9 BIOMOLECULES
JI Biomolecules
PD DEC
PY 2018
VL 8
IS 4
AR 160
DI 10.3390/biom8040160
PG 14
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA HF8WZ
UT WOS:000454524200063
PM 30513998
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Whalen, KA
   McCullough, ML
   Flanders, WD
   Hartman, TJ
   Judd, S
   Bostick, RM
AF Whalen, Kristine A.
   McCullough, Marjorie L.
   Flanders, W. Dana
   Hartman, Terryl J.
   Judd, Suzanne
   Bostick, Roberd M.
TI Paleolithic and Mediterranean Diet Pattern Scores Are Inversely
   Associated with Biomarkers of Inflammation and Oxidative Balance in
   Adults
SO JOURNAL OF NUTRITION
LA English
DT Article
DE inflammation; C-reactive protein; oxidative balance; F-2-isoprostanes;
   Paleolithic diet; Mediterranean diet; diet patterns; cross-sectional
   study
ID LOW-GRADE INFLAMMATION; COLORECTAL ADENOMA RISK; C-REACTIVE PROTEIN;
   METABOLIC SYNDROME; BETA-CAROTENE; LUNG-CANCER; DASH DIET;
   CARDIOVASCULAR-DISEASE; PLASMA-CONCENTRATIONS; LIPID-PEROXIDATION
AB Background: Chronic inflammation and oxidative balance are associated with poor diet quality and risk of cancer and other chronic diseases. A diet inflammation/oxidative balance association may relate to evolutionary discordance.
   Objective: We investigated associations between 2 diet pattern scores, the Paleolithic and the Mediterranean, and circulating concentrations of 2 related biomarkers, high-sensitivity C-reactive protein (hsCRP), an acute inflammatory protein, and F-2-isoprostane, a reliable marker of in vivo lipid peroxidation.
   Methods: In a pooled cross-sectional study of 30- to 74-y-old men and women in an elective outpatient colonoscopy population (n = 646), we created diet scores from responses on Willett food-frequency questionnaires and measured plasma hsCRP and F-2-isoprostane concentrations by ELISA and gas chromatography mass spectrometry, respectively. Both diet scores were calculated and categorized into quintiles, and their associations with biomarker concentrations were estimated with the use of general linear models to calculate and compare adjusted geometric means, and via unconditional ordinal logistic regression.
   Results: There were statistically significant trends for decreasing geometric mean plasma hsCRP and F-2-isoprostane concentrations with increasing quintiles of the Paleolithic and Mediterranean diet scores. The multivariable-adjusted ORs comparing those in the highest with those in the lowest quintiles of the Paleolithic and Mediterranean diet scores were 0.61 (95% CI: 0.36, 1.05; P-trend = 0.06) and 0.71 (95% CI: 0.42, 1.20; P-trend = 0.01), respectively, for a higher hsCRP concentration, and 0.51 (95% CI: 0.27, 0.95; P-trend 0.01) and 0.39 (95% CI: 0.21, 0.73; P-trend = 0.01), respectively, for a higher F-2-isoprostane concentration.
   Conclusion: These findings suggest that diets that are more Paleolithic- or Mediterranean-like may be associated with lower levels of systemic inflammation and oxidative stress in humans.
C1 [Whalen, Kristine A.; Flanders, W. Dana; Hartman, Terryl J.; Bostick, Roberd M.] Emory Univ, Dept Epidemiol, Atlanta, GA 30322 USA.
   [Flanders, W. Dana] Emory Univ, Rollins Sch Publ Hlth, Dept Biostat & Bioinformat, Atlanta, GA 30322 USA.
   [Flanders, W. Dana; Hartman, Terryl J.; Bostick, Roberd M.] Emory Univ, Winship Canc Inst, Atlanta, GA 30322 USA.
   [McCullough, Marjorie L.] Amer Canc Soc, Epidemiol Res Program, Atlanta, GA 30329 USA.
   [Judd, Suzanne] Univ Alabama Birmingham, Dept Biostat, Birmingham, AL 35294 USA.
C3 Emory University; Emory University; Rollins School Public Health; Emory
   University; American Cancer Society; University of Alabama System;
   University of Alabama Birmingham
RP Bostick, RM (corresponding author), Emory Univ, Dept Epidemiol, Atlanta, GA 30322 USA.; Bostick, RM (corresponding author), Emory Univ, Winship Canc Inst, Atlanta, GA 30322 USA.
EM rmbosti@emory.edu
OI Whalen, Kristine/0000-0003-4418-6233; McCullough,
   Marjorie/0000-0003-3025-6341
FU National Cancer Institute, NIH [R01 CA66539, R01 CA116795]; Fullerton
   Foundation; Franklin Foundation
FX Supported by the National Cancer Institute, NIH grants R01 CA66539 and
   R01 CA116795, the Fullerton Foundation, and the Franklin Foundation.
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NR 67
TC 91
Z9 99
U1 0
U2 40
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0022-3166
EI 1541-6100
J9 J NUTR
JI J. Nutr.
PD JUN
PY 2016
VL 146
IS 6
BP 1217
EP 1226
DI 10.3945/jn.115.224048
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA DN4RI
UT WOS:000377054500010
PM 27099230
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Wei, J
   Lei, GH
   Fu, L
   Zeng, C
   Yang, T
   Peng, SF
AF Wei, Jie
   Lei, Guang-hua
   Fu, Lei
   Zeng, Chao
   Yang, Tuo
   Peng, Shi-fang
TI Association between Dietary Vitamin C Intake and Non-Alcoholic Fatty
   Liver Disease: A Cross-Sectional Study among Middle-Aged and Older
   Adults
SO PLOS ONE
LA English
DT Article
ID MORBIDLY OBESE-PATIENTS; METABOLIC SYNDROME; CHINESE ADULTS;
   ASCORBIC-ACID; INSULIN-RESISTANCE; ANTIOXIDANT STATUS; OXIDATIVE STRESS;
   STEATOHEPATITIS; CHILDREN; SERUM
AB Background
   Non-alcoholic fatty liver disease (NAFLD) has become one of the most prevalent chronic liver disease all over the world. The objective of this study was to evaluate the association between dietary vitamin C intake and NAFLD.
   Method
   Subjects were diagnosed with NAFLD by abdominal ultrasound examination and the consumption of alcohol was less than 40g/day for men or less than 20g/day for women. Vitamin C intake was classified into four categories according to the quartile distribution in the study population: <= 74.80 mg/day, 74.81-110.15 mg/day, 110.16-146.06 mg/day, and >= 146.07 mg/day. The energy and multi-variable adjusted odds ratio (OR), as well as their corresponding 95% confidence interval (CI), were used to determine the relationship between dietary vitamin C intake and NAFLD through logistic regression.
   Result
   The present cross-sectional study included 3471 subjects. A significant inverse association between dietary vitamin C intake and NAFLD was observed in the energy-adjusted and the multivariable model. The multivariable adjusted ORs (95% CI) for NAFLD were 0.69 (95% CI: 0.54-0.89), 0.93 (95% CI: 0.72-1.20), and 0.71 (95% CI: 0.53-0.95) in the second, third and fourth dietary vitamin C intake quartiles, respectively, compared with the lowest (first) quartile. The relative odds of NAFLD was decreased by 0.71 times in the fourth quartile of dietary vitamin C intake compared with the lowest quartile. After stratifying data by sex or the status of obesity, the inverse association remained valid in the male population or non-obesity population, but not in the female population or obesity population.
   Conclusion
   There might be a moderate inverse association between dietary vitamin C intake and NAFLD in middle-aged and older adults, especially for the male population and non-obesity population.
C1 [Wei, Jie; Peng, Shi-fang] Cent S Univ, Xiangya Hosp, Hlth Management Ctr, Changsha, Hunan, Peoples R China.
   [Fu, Lei; Peng, Shi-fang] Cent S Univ, Xiangya Hosp, Dept Infect Dis, Changsha, Hunan, Peoples R China.
   [Wei, Jie] Cent S Univ, Sch Publ Hlth, Dept Epidemiol & Hlth Stat, Changsha, Hunan, Peoples R China.
   [Lei, Guang-hua; Zeng, Chao; Yang, Tuo] Cent S Univ, Xiangya Hosp, Dept Orthopaed, Changsha, Hunan, Peoples R China.
C3 Central South University; Central South University; Central South
   University; Central South University
RP Peng, SF (corresponding author), Cent S Univ, Xiangya Hosp, Hlth Management Ctr, Changsha, Hunan, Peoples R China.; Peng, SF (corresponding author), Cent S Univ, Xiangya Hosp, Dept Infect Dis, Changsha, Hunan, Peoples R China.
EM sfp1988@hotmail.com
RI Fu, Lei/AAB-1026-2020; Wei, Jie/ACR-8087-2022; yang, tuo/HNQ-8667-2023
OI Wei, Jie/0000-0003-3510-8241
FU Hunan Provincial Innovation Foundation for Postgraduate [CX2014B096];
   Fundamental Research Funds for the Central Universities of Central South
   University [2014zzts070]
FX JW accepted funding support from Hunan Provincial Innovation Foundation
   for Postgraduate (CX2014B096), the Fundamental Research Funds for the
   Central Universities of Central South University (2014zzts070). The
   funders had no role in study design, data collection and analysis,
   decision to publish, or preparation of the manuscript.
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NR 48
TC 61
Z9 64
U1 0
U2 20
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JAN 29
PY 2016
VL 11
IS 1
AR e0147985
DI 10.1371/journal.pone.0147985
PG 10
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA DC9GH
UT WOS:000369528600083
PM 26824361
OA gold, Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Indulekha, K
   Surendar, J
   Anjana, RM
   Geetha, L
   Gokulakrishnan, K
   Pradeepa, R
   Mohan, V
AF Indulekha, Karunakaran
   Surendar, Jayagopi
   Anjana, Ranjit Mohan
   Geetha, Loganathan
   Gokulakrishnan, Kuppan
   Pradeepa, Rajendra
   Mohan, Viswanathan
TI Metabolic Obesity, Adipocytokines, and Inflammatory Markers in Asian
   Indians-CURES-124
SO Diabetes Technology & Therapeutics
LA English
DT Article
ID DENSITY-LIPOPROTEIN CHOLESTEROL; URBAN-RURAL EPIDEMIOLOGY;
   ADIPOSE-TISSUE; INSULIN-RESISTANCE; NORMAL-WEIGHT; GLUCOSE-TOLERANCE;
   TNF-ALPHA; ADIPONECTIN; HEALTHY; RISK
AB Aim: This study looked at the association of adipokines, inflammatory and oxidative stress markers in subjects with the following phenotypes: metabolically healthy, nonobese (MHNO), metabolically healthy, obese (MHO), metabolically obese, nonobese (MONO), and metabolically obese, obese (MOO).
   Materials and Methods: Subjects with MHNO (n=462), MHO (n=192), MONO (n=315), and MOO (n=335) were randomly selected from the Chennai Urban Rural Epidemiology Study. Adiponectin, visfatin, resistin, high-sensitivity C-reactive protein (hs-CRP), tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), oxidized low-density lipoprotein (LDL), and monocyte chemoattractant protein-1 (MCP-1) were measured by enzyme-linked immunosorbent assay.
   Results: Levels of adiponectin were lowest in the MOO group, followed by the MONO, MHO, and the MHNO groups (P=0.042), whereas the levels of visfatin (P=0.042) and resistin (P=0.043) were highest in the MOO group, followed by the MONO, MHO, and the MHNO groups. Levels of hs-CRP (P=0.029), TNF-alpha (P=0.036), IL-6 (P=0.042), oxidized LDL (P=0.036), and MCP-1 (P=0.039) increased from the MHNO to MHO to MONO to MOO phenotypes. Linear regression analysis of the parameters with body mass index (BMI) and metabolic syndrome components showed that adiponectin is negatively associated with abdominal obesity (beta=-0.060; P=0.039) and BMI (beta=-0.076; P=0.009) and that TNF-alpha is negatively associated with high-density lipoprotein levels (beta=0.114, P=0.049) even after adjusting for age and gender. hs-CRP (beta=0.112, P=0.020) and oxidized LDL (beta=0.114, P=0.050) showed a positive association with systolic blood pressure even after adjusting for age and gender.
   Conclusions: The metabolically obese phenotype is characterized by altered adipokine and inflammatory profiles, which could make this phenotype at high risk for type 2 diabetes mellitus and cardiovascular diseases.
C1 [Mohan, Viswanathan] Madras Diabet Res Fdn, Madras 600086, Tamil Nadu, India.
   [Mohan, Viswanathan] Int Diabet Federat Ctr Educ, WHO Collaborating Ctr Noncommunicable Dis Prevent, Dr Mohans Diabet Special Ctr, Madras 600086, Tamil Nadu, India.
C3 Madras Diabetes Research Foundation
RP Mohan, V (corresponding author), Madras Diabet Res Fdn, 4 Conran Smith Rd, Madras 600086, Tamil Nadu, India.
EM drmohans@diabetes.ind.in
RI GOKULAKRISHNAN, KUPPAN/AAT-3244-2020; Pradeepa, Rajendra/ADN-8398-2022;
   Viswanathan, Mohan/C-2321-2009
OI Mohan, Viswanathan/0000-0001-5038-6210; GOKULAKRISHNAN,
   KUPPAN/0000-0003-3167-8239; Karunakaran, Indulekha/0000-0002-4014-4880;
   Pradeepa, Rajendra/0000-0002-4909-3733
FU Chennai Wellingdon Corporate Foundation; CSIR
FX We acknowledge the Chennai Wellingdon Corporate Foundation, which
   supported the CURES field studies. J.S. and I.K. acknowledge the CSIR
   for the Senior Research Fellowship.
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NR 32
TC 33
Z9 37
U1 0
U2 6
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1520-9156
EI 1557-8593
J9 DIABETES TECHNOL THE
JI Diabetes Technol. Ther.
PD FEB 1
PY 2015
VL 17
IS 2
BP 134
EP 141
DI 10.1089/dia.2014.0202
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA CA6GU
UT WOS:000349009600010
PM 25478993
DA 2025-06-11
ER

PT J
AU López-Guimerà, G
   Dashti, HS
   Smith, CE
   Sánchez-Carracedo, D
   Ordovas, JM
   Garaulet, M
AF Lopez-Guimera, Gemma
   Dashti, Hassan S.
   Smith, Caren E.
   Sanchez-Carracedo, David
   Ordovas, Jose M.
   Garaulet, Marta
TI CLOCK 3111 T/C SNP Interacts with Emotional Eating Behavior for
   Weight-Loss in a Mediterranean Population
SO PLOS ONE
LA English
DT Article
ID FOOD-INTAKE; METABOLIC SYNDROME; LOSS MAINTENANCE; LIFE-STYLE; OBESITY;
   OVERWEIGHT; GENE; STRESS; PREDICTORS; WOMEN
AB Objective: The goals of this research was (1) to analyze the role of emotional eating behavior on weight-loss progression during a 30-week weight-loss program in 1,272 individuals from a large Mediterranean population and (2) to test for interaction between CLOCK 3111 T/C SNP and emotional eating behavior on the effectiveness of the weight-loss program.
   Design and Methods: A total of 1,272 overweight and obese participants (BMI: 31 +/- 5 kg/m(2)), aged 20 to 65 years, attending outpatient weight-loss clinics were recruited for this analysis. Emotional eating behavior was assessed by the Emotional Eating Questionnaire (EEQ), a questionnaire validated for overweight and obese Spanish subjects. Anthropometric measures, dietary intake and weight-loss progression were assessed and analyzed throughout the 30-week program. Multivariate analysis and linear regression models were performed to test for gene-environment interaction.
   Results: Weight-loss progression during the 30-week program differed significantly according to the degree of emotional eating behavior. Participants classified as 'very emotional eaters' experienced more irregular (P = 0.007) weight-loss, with a lower rate of weight decline (-0.002 vs. -0.003, P<0.05) in comparison with less emotional eaters. The percentage of weight-loss was also significantly higher in 'non-emotional eaters' (P = 0.009). Additionally, we identified a significant gene-environment interaction associated with weight-loss at the CLOCK 3111 T/C locus (P = 0.017). By dichotomizing the emotional eating behavior score, linear regression analysis indicated that minor C allele carriers with a high emotional score (> = 11), lost significantly less weight than those C carriers with a low emotional score (<11) (P = 0.005).
   Conclusions: Emotional eating behavior associates with weight-loss pattern, progression and total weight-loss. Additionally, CLOCK 3111 T/C SNP interacts with emotional eating behavior to modulate total weight loss. These results suggest that the assessment of this locus and emotional eating behavior could improve the development of effective, long-tern weight-management interventions.
C1 [Lopez-Guimera, Gemma; Sanchez-Carracedo, David] Univ Autonoma Barcelona, Dept Clin & Hlth Psychol, E-08193 Barcelona, Spain.
   [Dashti, Hassan S.; Smith, Caren E.; Ordovas, Jose M.] Tufts Univ, Nutr & Genom Lab, Jean Mayer US Dept Agr, Human Nutr Res Ctr Aging, Boston, MA 02111 USA.
   [Garaulet, Marta] Univ Murcia, Dept Physiol, Murcia, Spain.
   [Ordovas, Jose M.] CNIC, Dept Epidemiol, Madrid, Spain.
   [Ordovas, Jose M.] Inst Madrileno Estudios Avanzados Alimentac IMDEA, Madrid, Spain.
C3 Autonomous University of Barcelona; Tufts University; United States
   Department of Agriculture (USDA); University of Murcia; Centro Nacional
   de Investigaciones Cardiovasculares (CNIC)
RP Garaulet, M (corresponding author), Univ Murcia, Dept Physiol, Murcia, Spain.
EM garaulet@um.es
RI Sánchez-Carracedo, David/A-4505-2009; Lopez-Guimera, Gemma/A-3542-2013;
   Garaulet, Marta/K-6625-2014; Ordovas, Jose/B-8727-2013
OI Dashti, Hassan/0000-0002-1650-679X; Sanchez-Carracedo,
   David/0000-0002-3945-6940; Ordovas, Jose/0000-0002-7581-5680; Garaulet,
   Marta/0000-0002-4066-3509
FU NHLBI NIH HHS [R01 HL054776, HL-54776, K08 HL112845] Funding Source:
   Medline; NIDDK NIH HHS [R01 DK075030, DK075030] Funding Source: Medline;
   NIMHD NIH HHS [L60 MD003562] Funding Source: Medline
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NR 58
TC 43
Z9 44
U1 1
U2 13
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JUN 6
PY 2014
VL 9
IS 6
AR e99152
DI 10.1371/journal.pone.0099152
PG 8
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA AP1YS
UT WOS:000341869000106
PM 24905098
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Calixto-Tlacomulco, S
   Luna-Reyes, I
   Delgado-Coello, B
   Gutiérrez-Vidal, R
   Reyes-Grajeda, JP
   Mas-Oliva, J
AF Calixto-Tlacomulco, Sandra
   Luna-Reyes, Ismael
   Delgado-Coello, Blanca
   Gutierrez-Vidal, Roxana
   Reyes-Grajeda, Juan Pablo
   Mas-Oliva, Jaime
TI CETP-derived Peptide Seq-1, the Key Component of HB-ATV-8 Vaccine
   Prevents Stress Responses, and Promotes Downregulation of Pro-Fibrotic
   Genes in Hepatocytes and Stellate Cells
SO ARCHIVES OF MEDICAL RESEARCH
LA English
DT Article
DE Vaccine HB-ATV-8; NAFDL; Inflammation; Pro-fibrotic genes; Hepatocytes;
   Hepatic stellate cells
ID FATTY LIVER-DISEASE; CHOLESTERYL ESTER TRANSFER; INSULIN-RESISTANCE;
   METABOLIC SYNDROME; TRANSFER PROTEIN; AMINO-ACIDS; ACTIVATION; FIBROSIS;
   LIPOTOXICITY; PATHOGENESIS
AB Background. The nasal vaccine HB-ATV-8 has emerged as a promising approach for NAFLD (non-alcoholic fatty liver disease) and atherosclerosis prevention. HB-ATV-8 contains peptide seq-1 derived from the carboxy-end of the Cholesteryl Ester Transfer Protein (CETP), shown to reduce liver fibrosis, inflammation, and atherosclerotic plaque formation in animal models. Beyond the fact that this vaccine induces B-cell lymphocytes to code for antibodies against the seq-1 sequence, inhibiting CETP's cholesterol transfer activity, we have hypothesized that beyond the modulation of CETP activity carried out by neutralizing antibodies, the observed molecular effects may also correspond to the direct action of peptide seq-1 on diverse cellular systems and molecular features involved in the development of liver fibrosis. Methods. The HepG2 hepatoma-derived cell line was employed to establish an in vitro steatosis model. To obtain a conditioned cell medium to be used with hepatic stellate cell (HSC) cultures, HepG2 cells were exposed to fatty acids or fatty acids plus peptide seq-1, and the culture medium was collected. Gene regulation of COL1A1, ACTA2, TGF-beta, and the expression of proteins COL1A1, MMP-2, and TIMP-2 were studied. Aim. To establish an in vitro steatosis model employing HepG2 cells that mimics molecular processes observed in vivo during the onset of liver fibrosis. To evaluate the effect of peptide Seq-1 on lipid accumulation and pro-fibrotic responses. To study the effect of Seq-1-treated steatotic HepG2 cell supernatants on lipid accumulation, oxidative stress, and pro-fibrotic responses in HSC. Results and Conclusion. Peptide seq-1-treated HepG2 cells show a downregulation of COLIA1, ACTA2, and TGF-beta genes, and a decreased expression of proteins such as COL1A1, MMP-2, and TIMP-2, associated with the remodeling of extracellular matrix components. The same results are observed when HSCs are incubated with peptide Seq-1-treated steatotic HepG2 cell supernatants. The present study consolidates the nasal vaccine HB-ATV-8 as a new prospect in the treatment of NASH directly associated with the development of cardiovascular disease. (c) 2023 The Authors. Published by Elsevier Inc. on behalf of Instituto Mexicano del Seguro Social (IMSS). This is an open access article under the CC BY-NC-ND license ( http://creativecommons.org/licenses/by-nc-nd/4.0/ )
C1 [Calixto-Tlacomulco, Sandra; Luna-Reyes, Ismael; Delgado-Coello, Blanca; Mas-Oliva, Jaime] Univ Nacl Autonoma Mexico, Cellular Physiol Inst, Mexico City, Mexico.
   [Reyes-Grajeda, Juan Pablo] Inst Nacl Med Genom, Prot Struct Lab, Mexico City, Mexico.
   [Gutierrez-Vidal, Roxana] Researchers Program Mexico CONAHCYT, Mexico City, Mexico.
   [Gutierrez-Vidal, Roxana] Cinvestav Unidad Monterey, Lab Metab Dis, Apodaca, Nuevo Leon, Mexico.
   [Mas-Oliva, Jaime] Univ Nacl Autonoma Mexico, Cellular Physiol Inst, Biochem & Struct Biol Dept, Mexico City 04510, Mexico.
C3 Universidad Nacional Autonoma de Mexico; Instituto Nacional de Medicina
   Genomica; Universidad Nacional Autonoma de Mexico
RP Mas-Oliva, J (corresponding author), Univ Nacl Autonoma Mexico, Cellular Physiol Inst, Biochem & Struct Biol Dept, Mexico City 04510, Mexico.
EM jmas@ifc.unam.mx
RI Reyes Grajeda, Juan Pablo/JYL-9713-2024; DELGADO-COELLO,
   BLANCA/HDO-2038-2022
OI Mas-Oliva, Jaime/0000-0001-8007-6993; DELGADO-COELLO,
   BLANCA/0000-0002-6822-3302; Calixto, Sandra/0009-0009-7385-5986
FU PAPIIT-UNAM [IN207121, IN209424]; CONAHCyT
FX This work has been supported by PAPIIT-UNAM (IN207121 and IN209424)
   awarded to J M -O. S. Calixto-Tlacomulco is a Ph.D. student in the
   Doctoral Program in Biomedical Sciences, and I. Luna-Reyes is a Ph.D.
   student in the Masters and Doctorate Program in Biochemical Sciences,
   both at Universidad Nacional Autonoma de Mexico. Both students have
   received scholarships from CONAHCyT during their graduate studies. The
   authors thank Paul Gaytan, Santiago Becerra, Jorge Yanez, and Eugenio
   Lopez of IBT-UNAM for the synthesis of highquality oligonucleotides. The
   authors also thank Dr. Ruth Rincon Heredia for her expert advice on
   confocal microscopy techniques.
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NR 72
TC 3
Z9 3
U1 1
U2 11
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0188-4409
EI 1873-5487
J9 ARCH MED RES
JI Arch. Med. Res.
PD FEB
PY 2024
VL 55
IS 2
AR 102937
DI 10.1016/j.arcmed.2023.102937
EA FEB 2024
PG 15
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA KP8V8
UT WOS:001181271900001
PM 38301446
OA hybrid
DA 2025-06-11
ER

PT J
AU O'Neil, DS
   Stewart, CJ
   Chu, DM
   Goodspeed, DM
   Gonzalez-Rodriguez, PJ
   Shope, CD
   Aagaard, KM
AF O'Neil, Derek S.
   Stewart, Christopher J.
   Chu, Derrick M.
   Goodspeed, Danielle M.
   Gonzalez-Rodriguez, Pablo J.
   Shope, Cynthia D.
   Aagaard, Kjersti M.
TI Conditional postnatal deletion of the neonatal murine hepatic circadian
   gene, Npas2, alters the gut microbiome following restricted
   feeding
SO AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
LA English
DT Article
DE gut microbiome; mouse model; Npas2; peripheral circadian clock;
   restricted feeding
ID HIGH-FAT DIET; METABOLIC SYNDROME; MATERNAL DIET; INTESTINAL MICROBIOTA;
   PLACENTAL MICROBIOME; CLOCK; ASSOCIATION; EXPOSURE; OBESITY;
   SUSCEPTIBILITY
AB BACKGROUND: We have recently shown in both non-human primates and in rodents that fetal and neonatal hepatic expression of the circadian transcription factor, Npas2, is modulated by a high fat maternal diet and plays a critical role in establishing life-long metabolic homeostasis. Similarly, we and others have also established the importance of the maternal and early postnatal diet on establishment of the early gut microbiome.
   OBJECTIVE: We hypothesized that altered circadian gene expression solely in the neonatal liver would result in gut microbiome dysbiosis, especially with diet-induced metabolic stress (ie, restricted feeding). Using a murine model in which we conditionally knock out Npas2 in the neonatal liver, we aimed to determine the role of the circadian machinery in gut dysbiosis with restricted feeding.
   STUDY DESIGN: We collected fecal samples from liver Npas2 conditional knockout (n = 11) and wild-type (n = 13) reproductive-aged mice before (study day 0) and after the restricted feeding study (study day 17). Extracted DNA was sequenced using the MiSeq Illumina platform using primers specific for the V4 region of the 16S ribosomal DNA gene. The resulting sequences were quality filtered, aligned, and assigned taxonomy. Principal coordinate analysis was performed on unweighted and weighted UniFrac distances between samples with a permutation analysis of variance to assess clustering significance between groups. Microbial taxa that significantly differ between groups of interest was determined using linear discriminate analysis effect size and randomForrest.
   RESULTS: Principal coordinate analysis performed on weighted UniFrac distances between male conditional knockout and wild-type cohorts revealed that the gut microbiome of the mice did not differ by genotype at the start of the restricted feeding study but did differ by virtue of genotype at the end of the study (P = .001). Moreover, these differences could be at least partially attributed to restricted feeding-associated alterations in relative abundance of the Bacteroides genus, which has been implicated as crucial to establishing a healthy gut microbiome early in development.
   CONCLUSION: Here we have provided an initial key insight into the interplay between neonatal establishment of the peripheral circadian clock in the liver and the ability of the gut microbiome to respond to dietary and metabolic stress. Because Npas2 expression in the liver is a target of maternal high-fat diet-induced metabolic perturbations during fetal development, we speculate that these findings have potential implications in the long-term metabolic health of their offspring.
C1 [O'Neil, Derek S.; Chu, Derrick M.; Goodspeed, Danielle M.; Gonzalez-Rodriguez, Pablo J.; Shope, Cynthia D.; Aagaard, Kjersti M.] Baylor Coll Med, Dept Obstet & Gynecol, Div Maternal Fetal Med, Houston, TX 77030 USA.
   [Aagaard, Kjersti M.] Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA.
   [Aagaard, Kjersti M.] Baylor Coll Med, Dept Mol & Cell Biol, Houston, TX 77030 USA.
   [Aagaard, Kjersti M.] Baylor Coll Med, Dept Mol & Cellular Physiol, Houston, TX 77030 USA.
   [Stewart, Christopher J.] Baylor Coll Med, Dept Mol Virol & Microbiol, Houston, TX 77030 USA.
   [O'Neil, Derek S.; Chu, Derrick M.; Aagaard, Kjersti M.] Baylor Coll Med, Interdept Grad Program Translat Biol & Mol Med, Houston, TX 77030 USA.
C3 Baylor College of Medicine; Baylor College of Medicine; Baylor College
   of Medicine; Baylor College of Medicine; Baylor College of Medicine;
   Baylor College of Medicine
RP Aagaard, KM (corresponding author), Baylor Coll Med, Dept Obstet & Gynecol, Div Maternal Fetal Med, Houston, TX 77030 USA.; Aagaard, KM (corresponding author), Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA.; Aagaard, KM (corresponding author), Baylor Coll Med, Dept Mol & Cell Biol, Houston, TX 77030 USA.; Aagaard, KM (corresponding author), Baylor Coll Med, Dept Mol & Cellular Physiol, Houston, TX 77030 USA.; Aagaard, KM (corresponding author), Baylor Coll Med, Interdept Grad Program Translat Biol & Mol Med, Houston, TX 77030 USA.
EM aagaardt@bcm.edu
RI Stewart, Christopher/M-4615-2017
OI Stewart, Christopher/0000-0002-6033-338X
FU Department of Agriculture Agricultural Research Service
FX We thank the Alkek Center for Metagenomics and Microbiome Research at
   Baylor College of Medicine for generating the 16S sequencing data.
   Measurements of food intake were performed in the Mouse Metabolic
   Research Unit at the US Department of Agriculture/Agricultural Research
   Service Children's Nutrition Research Center, Baylor College of
   Medicine, which is supported by funds from the Department of Agriculture
   Agricultural Research Service (www. bcm.edu/cnrc/mmru). We acknowledge
   the expert assistance of Mr Firoz Vohra and the Mouse Metabolic Research
   Unit Core Director, Dr Marta Fiorotto, with the latter experiments.
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NR 64
TC 11
Z9 12
U1 0
U2 16
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0002-9378
EI 1097-6868
J9 AM J OBSTET GYNECOL
JI Am. J. Obstet. Gynecol.
PD AUG
PY 2017
VL 217
IS 2
AR 218.e1-e15
DI 10.1016/j.ajog.2017.03.024
PG 15
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA FC2NY
UT WOS:000406676300032
PM 28373017
OA Green Accepted, Green Published
DA 2025-06-11
ER

PT J
AU Cheng, LC
   Wang, XY
   Dang, KK
   Hu, JX
   Zhang, J
   Xu, XQ
   Pan, SJ
   Qi, X
   Li, Y
AF Cheng, Licheng
   Wang, Xuanyang
   Dang, Keke
   Hu, Jinxia
   Zhang, Jia
   Xu, Xiaoqing
   Pan, Sijia
   Qi, Xiang
   Li, Ying
TI Association of oxidative balance score with incident cardiovascular
   disease in patients with type 2 diabetes: findings of the UK Biobank
   study
SO EUROPEAN JOURNAL OF NUTRITION
LA English
DT Article
DE Oxidative stress; Oxidative balance score; Cardiovascular diseases; Type
   2 diabetes; UK Biobank
ID FATTY LIVER-DISEASE; REFINED-GRAIN CONSUMPTION; METABOLIC SYNDROME;
   STRESS; INFLAMMATION; RISK; CANCER; MORTALITY; PROTEIN; CARE
AB Background & aimsTo clarify how dietary and lifestyle factors work on diabetes-related cardiovascular disease (CVD), we investigated whether the increased risk of CVD in patients with type 2 diabetes mellitus (T2DM) could be offset by an increase in diet and/or lifestyle with antioxidant potential.Research design and methodsA total of 7,658 individuals from UK Biobank (UKB) with T2DM but no diagnosed CVD were included in this study. We screened combinations of 16 nutrients and/or 4 lifestyles to calculate the Oxidative Balance Score (OBS), dietary OBS (DOBS), and lifestyle OBS (LOBS). Cox proportional hazards (CPH) regression models and mediation statistical models were performed.ResultsAfter adjusting for covariates, CPH regression models showed inverse associations between both OBS and LOBS and CVD. The highest tertile of LOBS was significantly associated with a lower risk of CVD compared to the lowest tertile, with hazard ratios and 95% CIs as follows: Atherosclerotic Cardiovascular Disease (ASCVD) 0.81 (0.68-0.97), Coronary Artery Disease (CAD) 0.79 (0.67-0.93), Atrial Fibrillation (AF) 0.56 (0.45-0.70) and CVD mortality 0.67(0.51-0.88). Correspondingly, the results of associations between the highest tertile of OBS and risks of CVDs above were ASCVD 0.80 (0.64-0.99), CAD 0.83(0.68-1.01), AF 0.73 (0.57-0.92) and CVD mortality 0.68 (0.50-0.92). No associations between DOBS and CVDs were observed [ASCVD 0.83 (0.66-1.05), CAD 0.86 (0.70-1.05), AF 0.77 (0.60-1.00), and CVD mortality 0.79 (0.57-1.10)]. These results were consistent in stratified analyses. Additionally, we identified a mediating role for C-reactive protein (CRP) and white blood cell count (WBC) in the observed relations, with indirect effect and mediation estimates as follows: CRP - 0.003 6.0% (OBS and CAD), -0.008 17.2%, -0.003 11.7%, and - 0.010 14.5% (OBS/DOBS/LOBS and CVD mortality); WBC - 0.006 14.3%, -0.006 12.6%, -0.006 13.4%, -0.005 23.3% (OBS and CVDs), -0.008 11.8%, -0.008 11.9%, -0.008 11.8%, and - 0.005 5.3% (LOBS and CVDs).ConclusionSustained adherence to diets and lifestyles with high antioxidant potential may significantly reduce the risk of CVD in individuals with T2DM.
C1 [Cheng, Licheng; Wang, Xuanyang; Dang, Keke; Hu, Jinxia; Zhang, Jia; Xu, Xiaoqing; Pan, Sijia; Qi, Xiang; Li, Ying] Harbin Med Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Natl Key Discipline, 157 Baojian Rd, Harbin 150081, Peoples R China.
C3 Harbin Medical University
RP Li, Y (corresponding author), Harbin Med Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Natl Key Discipline, 157 Baojian Rd, Harbin 150081, Peoples R China.
EM lichengcheng4646@163.com; 2020020226@hrbmu.edu.cn; dangkeke666@163.com;
   17837179203@163.com; april_zhangj@163.com; xxqyeah1999@163.com;
   pansijia1020@163.com; q572249383@163.com; liying_helen@163.com
FU National Natural Science Foundation of China
FX All authors expressed their gratitude to the participants involved in
   the UK Biobank for their priceless contributions.
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NR 80
TC 0
Z9 0
U1 5
U2 5
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1436-6207
EI 1436-6215
J9 EUR J NUTR
JI Eur. J. Nutr.
PD APR
PY 2025
VL 64
IS 3
AR 110
DI 10.1007/s00394-024-03552-2
PG 13
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA Z6A7K
UT WOS:001439715400001
PM 40047957
DA 2025-06-11
ER

PT J
AU Zeng, CM
   He, J
   Wang, DC
   Xie, H
AF Zeng, Chang-Mei
   He, Jun
   Wang, Deng-Chao
   Xie, Hong
TI Association between triglyceride levels and rheumatoid arthritis
   prevalence in women: a cross-sectional study of NHANES (1999-2018)
SO BMC WOMENS HEALTH
LA English
DT Article
DE Rheumatoid arthritis; Triglycerides; Women; NHANES; Logistic regression;
   Nonlinear association; Eepidemiology
ID HIGH-DENSITY-LIPOPROTEIN; METABOLIC SYNDROME; RICH LIPOPROTEINS;
   OXIDATIVE STRESS; LIPID PROFILE; UNITED-STATES; INFLAMMATION;
   MECHANISMS; SMOKING; DISEASE
AB Background Rheumatoid arthritis (RA) is a chronic autoimmune disease with a higher prevalence in women. Triglycerides, key indicators of lipid metabolism, are linked to inflammation and metabolic disorders, both contributing to RA pathogenesis. However, the association between triglyceride levels and RA prevalence in women remains unclear. This study analyzes this association using NHANES (1999-2018) data to provide evidence for prevention and personalized intervention strategies. Methods This study utilized data from the National Health and Nutrition Examination Survey (NHANES) spanning 1999 to 2018. It included 10,728 female participants, of whom 639 were diagnosed with RA. Triglyceride levels were categorized into four quartiles (Q1 to Q4), and multivariable logistic regression models were used to analyze the association between triglyceride levels and RA prevalence in women. Restricted cubic spline (RCS) analyses were performed to evaluate the potential nonlinear association between triglyceride levels and RA prevalence. Subgroup and interaction analyses were conducted to further investigate the association across different populations. Results Among the 639 RA patients, higher triglyceride levels were significantly positively associated with RA prevalence in women. In the unadjusted model, elevated triglyceride levels were significantly associated with an increased RA prevalence (OR: 1.30, 95% CI: 1.04-1.61, P = 0.019). This association remained significant in the adjusted model, with the highest quartile showing a substantially higher risk compared to the lowest quartile (OR: 2.46, 95% CI: 1.22-4.95, P for trend = 0.04). RCS analyses indicated a linear association between triglyceride levels and RA prevalence (P for nonlinearity = 0.19). Subgroup analyses revealed consistent trends across various subgroups, with no significant interactions observed (all interaction P-values > 0.05). Conclusion This study demonstrates a significant positive association between elevated triglyceride levels and RA prevalence in women, with a linear trend observed in this association. Future research should further investigate the role of triglyceride levels in the pathogenesis of RA and explore potential intervention pathways.
C1 [Zeng, Chang-Mei; He, Jun] Suining Municipal Hosp Tradit Chinese Med, Dept Endocrinol & Metab Dis, Diabet Sect, Including Rheumatol Specialty, 73 Tianfeng St, Suining 629000, Sichuan, Peoples R China.
   [Wang, Deng-Chao] Zigong Fourth Peoples Hosp, Dept Gen Surg, Zigong 643000, Sichuan, Peoples R China.
   [Xie, Hong] Zigong Fourth Peoples Hosp, Dept Gen Med, Zigong 643000, Sichuan, Peoples R China.
RP Zeng, CM (corresponding author), Suining Municipal Hosp Tradit Chinese Med, Dept Endocrinol & Metab Dis, Diabet Sect, Including Rheumatol Specialty, 73 Tianfeng St, Suining 629000, Sichuan, Peoples R China.
EM changmeizeng@163.com
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NR 47
TC 0
Z9 0
U1 1
U2 1
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1472-6874
J9 BMC WOMENS HEALTH
JI BMC Womens Health
PD MAR 21
PY 2025
VL 25
IS 1
AR 129
DI 10.1186/s12905-025-03645-y
PG 11
WC Public, Environmental & Occupational Health; Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; Obstetrics & Gynecology
GA 0KU7V
UT WOS:001449742800001
PM 40119384
OA gold
DA 2025-06-11
ER

PT J
AU Glasstetter, LM
   Oderinde, TS
   Mirchandani, M
   Rajagopalan, KS
   Barsom, SH
   Thaler, R
   Siddiqi, S
   Zhu, XY
   Tang, H
   Jordan, KL
   Saadiq, IM
   van Wijnen, AJ
   Eirin, A
   Lerman, LO
AF Glasstetter, Logan M.
   Oderinde, Tomiwa S.
   Mirchandani, Mohit
   Rajagopalan, Kamalnath Sankaran
   Barsom, Samer H.
   Thaler, Roman
   Siddiqi, Sarosh
   Zhu, Xiang-Yang
   Tang, Hui
   Jordan, Kyra L.
   Saadiq, Ishran M.
   van Wijnen, Andre J.
   Eirin, Alfonso
   Lerman, Lilach O.
TI Obesity and dyslipidemia are associated with partially reversible
   modifications to DNA hydroxymethylation of apoptosis- and
   senescence-related genes in swine adipose-derived mesenchymal
   stem/stromal cells
SO STEM CELL RESEARCH & THERAPY
LA English
DT Article
DE Mesenchymal stem; stromal cells; Epigenetics; Hydroxymethylation;
   Apoptosis; Senescence; Obesity; Vitamin-C
ID STROMAL CELLS; METABOLIC SYNDROME; OXIDATIVE STRESS; STEM-CELLS;
   EXPRESSION; 5-HYDROXYMETHYLCYTOSINE; METHYLATION; CONVERSION; THERAPY;
   ALPHA
AB BackgroundObesity dysregulates key biological processes underlying the functional homeostasis, fate decisions, and reparative potential of mesenchymal stem/stromal cells (MSCs). Mechanisms directing obesity-induced phenotypic alterations in MSCs remain unclear, but emerging drivers include dynamic modification of epigenetic marks, like 5-hydroxymethylcytosine (5hmC). We hypothesized that obesity and cardiovascular risk factors induce functionally relevant, locus-specific changes in 5hmC of swine adipose-derived MSCs and evaluated their reversibility using an epigenetic modulator, vitamin-C.MethodsFemale domestic pigs were fed a 16-week Lean or Obese diet (n = 6 each). MSCs were harvested from subcutaneous adipose tissue, and 5hmC profiles were examined through hydroxymethylated DNA immunoprecipitation sequencing (hMeDIP-seq) followed by an integrative (hMeDIP and mRNA sequencing) gene set enrichment analysis. For clinical context, we compared 5hmC profiles of adipose tissue-derived human MSCs harvested from patients with obesity and healthy controls.ResultshMeDIP-seq revealed 467 hyper- (fold change >= 1.4; p-value <= 0.05) and 591 hypo- (fold change <= 0.7; p-value <= 0.05) hydroxymethylated loci in swine Obese- versus Lean-MSCs. Integrative hMeDIP-seq/mRNA-seq analysis identified overlapping dysregulated gene sets and discrete differentially hydroxymethylated loci with functions related to apoptosis, cell proliferation, and senescence. These 5hmC changes were associated with increased senescence in cultured MSCs (p16/CDKN2A immunoreactivity, senescence-associated beta-galactosidase [SA-beta-Gal] staining), were partly reversed in swine Obese-MSCs treated with vitamin-C, and shared common pathways with 5hmC changes in human Obese-MSCs.ConclusionsObesity and dyslipidemia are associated with dysregulated DNA hydroxymethylation of apoptosis- and senescence-related genes in swine and human MSCs, potentially affecting cell vitality and regenerative functions. Vitamin-C may mediate reprogramming of this altered epigenomic landscape, providing a potential strategy to improve the success of autologous MSC transplantation in obese patients.
C1 [Glasstetter, Logan M.; Oderinde, Tomiwa S.; Mirchandani, Mohit; Rajagopalan, Kamalnath Sankaran; Barsom, Samer H.; Siddiqi, Sarosh; Zhu, Xiang-Yang; Tang, Hui; Jordan, Kyra L.; Saadiq, Ishran M.; Eirin, Alfonso; Lerman, Lilach O.] Mayo Clin, Div Nephrol & Hypertens, 200 First St SW, Rochester, MN 55905 USA.
   [Thaler, Roman] Mayo Clin, Dept Orthoped Surg, Rochester, MN USA.
   [van Wijnen, Andre J.] Univ Vermont, Dept Biochem, Burlington, VT USA.
C3 Mayo Clinic; Mayo Clinic; University of Vermont
RP Lerman, LO (corresponding author), Mayo Clin, Div Nephrol & Hypertens, 200 First St SW, Rochester, MN 55905 USA.
EM lerman.lilach@mayo.edu
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NR 86
TC 8
Z9 8
U1 0
U2 7
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1757-6512
J9 STEM CELL RES THER
JI Stem Cell Res. Ther.
PD MAY 25
PY 2023
VL 14
IS 1
AR 143
DI 10.1186/s13287-023-03372-x
PG 19
WC Cell & Tissue Engineering; Cell Biology; Medicine, Research &
   Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Research & Experimental Medicine
GA H3HE2
UT WOS:000994901600002
PM 37231414
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Tan, L
   Zhou, QY
   Liu, J
   Liu, ZY
   Shi, RZ
AF Tan, Liao
   Zhou, Qiaoyu
   Liu, Jie
   Liu, Zhaoya
   Shi, Ruizheng
TI Association of iron status with non-alcoholic fatty liver disease and
   liver fibrosis in US adults: a cross-sectional study from NHANES
   2017-2018
SO FOOD & FUNCTION
LA English
DT Article
ID ELEVATED SERUM FERRITIN; HEPATIC STEATOSIS; OXIDATIVE STRESS; NAFLD
AB Aims: Non-alcoholic fatty liver disease (NAFLD) is a widely prevalent hepatic disorder resulting in a high risk of adverse prognosis, and its presence has been considered a cause or an outcome of metabolic syndrome. But the relative factors and mechanism of NAFLD are still unclear. The aim of this study is to explore the association between iron status indicators and NAFLD as well as liver fibrosis. Methods: This study evaluated whether serum iron status indicators are independently related to the risk of NAFLD. The independent variable was each one of the iron status indicators (iron intake, ferritin, iron, unsaturated iron binding force (UIBC), total iron binding capacity (TIBC), transferrin saturation, transferrin receptor, hemoglobin, and mean cell hemoglobin), and the dependent variables were NAFLD and advanced liver fibrosis. A multivariable logistic regression analysis and subgroup analysis were performed to evaluate the association between iron status indicators and NAFLD as well as liver fibrosis. Results: A total of 3727 patients were included. After adjusting for other covariates in multiple logistic regression models, the serum ferritin, UIBC, TIBC, and hemoglobin had a significant positive association with the NAFLD (odds ratio [OR] = 1.16, 95% confidence interval [CI]: 1.09, 1.23; 1.31, 95% CI: 1.06, 1.62; 1.82, 95% CI: 1.23, 2.67; 2.67, 95% CI: 1.48, 4.82, separately), and the risk of NAFLD diagnosed by VCTE or ALT/AST further increased in the fourth quartile group of serum ferritin (diagnosed by VCTE OR = 1.93, 95% CI: 1.49, 2.50; diagnosed by ALT/AST OR = 5.76, 95% CI: 3.96, 8.38). Moreover, the main positive correlation between serum ferritin and NAFLD was found in females, participants aged >41 years, with no diabetes. Conclusion: Our results indicated that iron status indicators were closely associated with the occurrence of advanced liver fibrosis, which may indicate that iron status indicators could be potential biomarkers of NAFLD and advanced liver fibrosis.
C1 [Tan, Liao; Zhou, Qiaoyu; Liu, Zhaoya] Cent South Univ, Xiangya Hosp 3, Dept Cardiol, Changsha, Peoples R China.
   [Liu, Jie; Shi, Ruizheng] Cent South Univ, Xiangya Hosp, Dept Cardiovasc Med, Changsha, Peoples R China.
   [Tan, Liao; Liu, Zhaoya] Cent South Univ, Xiangya Hosp 3, Dept Geriatr, Changsha, Peoples R China.
C3 Central South University; Central South University; Central South
   University
RP Liu, ZY (corresponding author), Cent South Univ, Xiangya Hosp 3, Dept Cardiol, Changsha, Peoples R China.; Shi, RZ (corresponding author), Cent South Univ, Xiangya Hosp, Dept Cardiovasc Med, Changsha, Peoples R China.; Liu, ZY (corresponding author), Cent South Univ, Xiangya Hosp 3, Dept Geriatr, Changsha, Peoples R China.
OI Tan, Liao/0009-0004-2936-4964
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NR 44
TC 17
Z9 17
U1 5
U2 30
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PD JUN 19
PY 2023
VL 14
IS 12
BP 5653
EP 5662
DI 10.1039/d2fo04082d
EA MAY 2023
PG 10
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA J0RC7
UT WOS:000997239300001
PM 37249386
DA 2025-06-11
ER

PT J
AU Baek, W
   Lee, JW
   Lee, HS
   Han, D
   Choi, SY
   Chun, EJ
   Han, HW
   Park, SH
   Sung, J
   Jung, HO
   Lee, H
   Chang, HJ
AF Baek, Wonhee
   Lee, Ji-Won
   Lee, Hye Sun
   Han, Donghee
   Choi, Su-Yeon
   Chun, Eun Ju
   Han, Hae-Won
   Park, Sung Hak
   Sung, Jidong
   Jung, Hae Ok
   Lee, Hyangkyu
   Chang, Hyuk-Jae
TI Concurrent smoking and alcohol consumers had higher triglyceride glucose
   indices than either only smokers or alcohol consumers: a cross-sectional
   study in Korea
SO LIPIDS IN HEALTH AND DISEASE
LA English
DT Article
DE Alcohol consumption; Cross-sectional study; Korean; Life-style
   modification; Smoking; Insulin resistance; Triglyceride glucose index
ID ENDOPLASMIC-RETICULUM STRESS; IMPAIRED INSULIN-SECRETION; METABOLIC
   SYNDROME; CIGARETTE-SMOKING; CONSUMPTION; ASSOCIATION; RESISTANCE;
   JAPANESE; TOBACCO; RISK
AB Background The triglyceride glucose (TyG) index is a noninsulin-based marker for insulin resistance (IR) in general practice. Although smoking and heavy drinking have been regarded as major risk factors for various chronic diseases, there is limited evidence regarding the combined effects of smoking and alcohol consumption on IR. This study aimed to investigate the relationship between the TyG index and smoking and alcohol consumption using two Korean population-based datasets. Methods This study included 10,568 adults in the Korean National Health and Nutrition Examination Survey (KNHANES) and 9586 adults in the Korean Initiatives on Coronary Artery Calcification (KOICA) registry datasets. Multivariate logistic analysis was conducted to explore the relationship between smoking and alcohol consumption and the TyG index. To assess the predictive value of smoking and alcohol consumption on high TyG index, the area under the curve (AUC) were compared and net reclassification improvement (NRI) and integrated discrimination improvement (IDI) analyses were derived. Results The combined effect of smoking and alcohol consumption was an independent risk factor of a higher TyG index in the KNHANES (adjusted odds ratio: 4.33, P < .001) and KOICA (adjusted odds ratio: 1.94, P < .001) datasets. Adding smoking and alcohol consumption to the multivariate logistic models improved the model performance for the TyG index in the KNHANES (AUC: from 0.817 to 0.829, P < .001; NRI: 0.040, P < .001; IDI: 0.017, P < .001) and KOICA (AUC: from 0.822 to 0.826, P < .001; NRI: 0.025, P = .006; IDI: 0.005, P < .001) datasets. Conclusions Smoking and alcohol consumption were independently associated with the TyG index. Concurrent smokers and alcohol consumers were more likely to have a TyG index that was >= 8.8 and higher than the TyG indices of non-users and those who exclusively consumed alcohol or smoking tobacco.
C1 [Baek, Wonhee; Lee, Hyangkyu] Yonsei Univ, Dept Nursing, Grad Sch, Seoul, South Korea.
   [Baek, Wonhee] Kyungnam Univ, Dept Nursing, Coll Hlth Sci, Chang Won, South Korea.
   [Lee, Ji-Won] Yonsei Univ, Dept Family Med, Gangnam Severance Hosp, Coll Med, Seoul, South Korea.
   [Lee, Hye Sun] Yonsei Univ, Dept Res Affairs, Biostat Collaborat Unit, Coll Med, Seoul, South Korea.
   [Han, Donghee] Cedars Sinai Med Ctr, Dept Imaging & Med, Los Angeles, CA 90048 USA.
   [Choi, Su-Yeon] Seoul Natl Univ, Seoul Natl Univ Healthcare Syst Gangnam Ctr, Div Cardiol, Coll Med, Seoul, South Korea.
   [Chun, Eun Ju] Seoul Natl Univ, Dept Radiol, Bundang Hosp, Seoul, South Korea.
   [Han, Hae-Won] Gangnam Heartscan Clin, Dept Internal Med, Seoul, South Korea.
   [Park, Sung Hak] Gangnam Heartscan Clin, Dept Radiol, Seoul, South Korea.
   [Sung, Jidong] Sungkyunkwan Univ, Heart Stroke & Vasc Inst, Dept Med, Samsung Med Ctr,Div Cardiol,Sch Med, Seoul, South Korea.
   [Jung, Hae Ok] Catholic Univ Korea, Seoul St Marys Hosp, Coll Med, Cardiovasc Ctr,Div Cardiol, Seoul, South Korea.
   [Lee, Hyangkyu] Yonsei Univ, Mo Im Kim Nursing Res Inst, Coll Nursing, 50-1 Yonsei Ro, Seoul 03722, South Korea.
   [Chang, Hyuk-Jae] Yonsei Univ, Yonsei Univ Hlth Syst, Severance Cardiovasc Hosp, Div Cardiol,Coll Med, Seoul, South Korea.
C3 Yonsei University; Kyungnam University; Yonsei University; Yonsei
   University Health System; Yonsei University; Yonsei University Health
   System; Cedars Sinai Medical Center; Seoul National University (SNU);
   Seoul National University Hospital; Seoul National University (SNU);
   Seoul National University Hospital; Sungkyunkwan University (SKKU);
   Samsung Medical Center; Seoul St. Mary's Hospital; Catholic University
   of Korea; Yonsei University; Yonsei University Health System; Yonsei
   University; Yonsei University Health System
RP Lee, H (corresponding author), Yonsei Univ, Dept Nursing, Grad Sch, Seoul, South Korea.; Lee, H (corresponding author), Yonsei Univ, Mo Im Kim Nursing Res Inst, Coll Nursing, 50-1 Yonsei Ro, Seoul 03722, South Korea.; Chang, HJ (corresponding author), Yonsei Univ, Yonsei Univ Hlth Syst, Severance Cardiovasc Hosp, Div Cardiol,Coll Med, Seoul, South Korea.
EM hkyulee@yuhs.ac; hjchang@yuhs.ac
RI LEE, Ji/C-2295-2009; Choi, Su-Yeon/C-4312-2013; Lee, Hye Sun/J-2154-2015
OI Lee, Hye Sun/0000-0001-6328-6948; Chang, Hyuk-Jae/0000-0002-6139-7545;
   BAEK, WONHEE/0000-0002-9832-231X; LEE, JI WON/0000-0002-2666-4249
FU Technology Innovation Program - Ministry of Trade, Industry and Energy
   (MOTIE, South Korea) [20002781]; National Research Foundation of Korea
   (NRF) - Korea government (MEST) [NRF-2019R1A2C1010043]; Institute for
   Information and Communications Technology Promotion (IITP) - Korean
   government (MSIT) [2019-31-1293]
FX This work was supported by the Technology Innovation Program (20002781,
   A Platform for Prediction and Management of Health Risk Based on
   Personal Big Data and Lifelogging) funded by the Ministry of Trade,
   Industry and Energy (MOTIE, South Korea) to JW Lee, and the National
   Research Foundation of Korea (NRF) grant funded by the Korea government
   (MEST) (NRF-2019R1A2C1010043) to H Lee. Additionally, this work was
   supported by Institute for Information and Communications Technology
   Promotion (IITP) grant funded by the Korean government (MSIT)
   (2019-31-1293), for autonomous digital companion framework and
   application to HJ Chang.
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NR 53
TC 12
Z9 13
U1 0
U2 9
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1476-511X
J9 LIPIDS HEALTH DIS
JI Lipids Health Dis.
PD MAY 11
PY 2021
VL 20
IS 1
AR 49
DI 10.1186/s12944-021-01472-2
PG 11
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA SA5TS
UT WOS:000649366500001
PM 33975592
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Straub, LG
   Efthymiou, V
   Grandl, G
   Balaz, M
   Challa, TD
   Truscello, L
   Horvath, C
   Moser, C
   Rachamin, Y
   Arnold, M
   Sun, WF
   Modica, S
   Wolfrum, C
AF Straub, Leon G.
   Efthymiou, Vissarion
   Grandl, Gerald
   Balaz, Miroslav
   Challa, Tenagne Delessa
   Truscello, Luca
   Horvath, Carla
   Moser, Caroline
   Rachamin, Yael
   Arnold, Myrtha
   Sun, Wenfei
   Modica, Salvatore
   Wolfrum, Christian
TI Antioxidants protect against diabetes by improving glucose homeostasis
   in mouse models of inducible insulin resistance and obesity
SO DIABETOLOGIA
LA English
DT Article
DE Acetovanillone; Adipocyte; Adipocyte quantification; Adipocyte-specific;
   Adipose tissue; Antioxidants; Apocynin; CreERT2; Diet-induced obesity;
   Fat; Hyperglycaemia; Hyperinsulinaemic-euglycaemic clamp; Hyperphagia;
   iFIRKO; Insulin receptor; Insulin resistance; Leptin deficiency;
   Lipolysis; N-acetylcysteine; ob; ob; Obesity resistance; Polydipsia
   obesity; Tamoxifen; Type 2 diabetes
ID METABOLIC SYNDROME; OXIDATIVE STRESS; LEPTIN; FAT; STEATOHEPATITIS;
   LIPOTOXICITY; GLUTATHIONE; ACTIVATION; APOCYNIN; HEALTH
AB Aims/hypothesis In the context of diabetes, the health benefit of antioxidant treatment has been widely debated. In this study, we investigated the effect of antioxidant treatment during the development of insulin resistance and hyperphagia in obesity and partial lipodystrophy. Methods We studied the role of antioxidants in the regulation of insulin resistance using the tamoxifen-inducible fat-specific insulin receptor knockout (iFIRKO) mouse model, which allowed us to analyse the antioxidant's effect in a time-resolved manner. In addition, leptin-deficient ob/ob mice were used as a hyperphagic, chronically obese and diabetic mouse model to validate the beneficial effect of antioxidants on metabolism. Results Acute induction of insulin receptor knockout in adipocytes changed the substrate preference to fat before induction of a diabetic phenotype including hyperinsulinaemia and hyperglycaemia. In healthy chow-fed animals as well as in morbidly obese mice, this diabetic phase could be reversed within a few weeks. Furthermore, after the induction of insulin receptor knockout in mature adipocytes, iFIRKO mice were protected from subsequent obesity development through high-fat diet feeding. By genetic tracing we show that the persistent fat mass loss in mice after insulin receptor knockout in adipocytes is not caused by the depletion of adipocytes. Treatment of iFIRKO mice with antioxidants postponed and reduced hyperglycaemia by increasing insulin sensitivity. In ob/ob mice, antioxidants rescued both hyperglycaemia and hyperphagia. Conclusions/interpretation We conclude that fat mass reduction through insulin resistance in adipocytes is not reversible. Furthermore, it seems unlikely that adipocytes undergo apoptosis during the process of extreme lipolysis, as a consequence of insulin resistance. Antioxidants have a beneficial health effect not only during the acute phase of diabetes development, but also in a temporary fashion once chronic obesity and diabetes have been established.
C1 [Straub, Leon G.; Efthymiou, Vissarion; Grandl, Gerald; Balaz, Miroslav; Challa, Tenagne Delessa; Truscello, Luca; Horvath, Carla; Moser, Caroline; Rachamin, Yael; Arnold, Myrtha; Sun, Wenfei; Modica, Salvatore; Wolfrum, Christian] Swiss Fed Inst Technol, Swiss Fed Inst Technol, Inst Food Nutr & Hlth, Lab Translat Nutr Biol, CH-8603 Schwerzenbach, Switzerland.
   [Straub, Leon G.] Univ Texas Southwestern Med Ctr Dallas, Touchstone Diabet Ctr, Dallas, TX 75390 USA.
   [Grandl, Gerald] Helmholtz Zentrum Munchen, Helmholtz Diabet Ctr, Inst Diabet & Obes, Neuherberg, Germany.
C3 Swiss Federal Institutes of Technology Domain; ETH Zurich; University of
   Texas System; University of Texas Southwestern Medical Center Dallas;
   Helmholtz Association; Helmholtz-Center Munich - German Research Center
   for Environmental Health
RP Wolfrum, C (corresponding author), Swiss Fed Inst Technol, Swiss Fed Inst Technol, Inst Food Nutr & Hlth, Lab Translat Nutr Biol, CH-8603 Schwerzenbach, Switzerland.
EM christian-wolfrum@ethz.ch
RI Efthymiou, Vissarion/JID-3423-2023; Rachamin, Yael/AAX-1748-2020; Sun,
   Wenfei/S-3513-2019; Balaz, Miroslav/E-8034-2018
OI Straub, Leon/0000-0001-6738-0130; Challa, PhD, Tenagne
   Delessa/0000-0002-5898-8061; Grandl, Gerald/0000-0003-4456-1988;
   Efthymiou, Vissarion/0000-0003-4327-7977; Sun,
   Wenfei/0000-0001-5762-6010; Wolfrum, Christian/0000-0002-3862-6805;
   Balaz, Miroslav/0000-0002-5740-4896; Rachamin, Yael/0000-0002-1484-6934
FU Schweizer Nationalfonds (SNF)
FX Funding was provided by the Schweizer Nationalfonds (SNF).
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NR 43
TC 28
Z9 29
U1 0
U2 10
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0012-186X
EI 1432-0428
J9 DIABETOLOGIA
JI Diabetologia
PD NOV
PY 2019
VL 62
IS 11
BP 2094
EP 2105
DI 10.1007/s00125-019-4937-7
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA JG2ZU
UT WOS:000491944900014
PM 31309261
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Al-Okbi, SY
   Mohamed, DA
   Hamed, TE
   Edris, AE
AF Al-Okbi, Sahar Y.
   Mohamed, Doha A.
   Hamed, Thanaa E.
   Edris, Amr E.
TI Protective Effect of Clove Oil and Eugenol Microemulsions on Fatty Liver
   and Dyslipidemia as Components of Metabolic Syndrome
SO JOURNAL OF MEDICINAL FOOD
LA English
DT Article
DE clove oil; eugenol; microemulsions; fatty liver; protective effect
ID CHRONIC HEPATITIS-C; NONALCOHOLIC STEATOHEPATITIS; IN-VITRO; MECHANISMS;
   DISEASE; NANOPARTICLES; ANTIOXIDANTS; FORMULATION; PROGRESSION;
   POTENTIALS
AB In the present research, the effect of clove essential oil (CO) and its major constituent, eugenol, formulated in water-based microemulsions, was studied on fatty liver and dyslipidemia in high-fructose-fed rats. Plasma and liver lipids, oxidative stress, inflammatory biomarker, and liver function were the assessed criteria. CO dispersed in water as conventional cloudy emulsion was also subjected to the same biological evaluations for comparison with the microemulsified form of this oil. Results showed that the particle size of CO microemulsion (COM) and eugenol microemulsion (EM) was 8.0 nm and 8.9 nm, respectively. Excess dilution and incubation of these microemulsions in 1.2N HCl, that mimic stomach juice (without lipase), for 5 hours at 37 degrees C lead to the establishment of second population of larger particles with average diameter >100.0 nm. Biological evaluation revealed that rats of high fructose control group exhibited significant dyslipidemia, high plasma tumor necrosis factor-a, and elevated malondialdehyde. The same group of rats showed significant high liver total fat, triglycerides and cholesterol, and liver dysfunction compared to control normal rats fed balanced diet. Daily oral administration of CO conventional emulsion, COM, and EM produced significant improvement of all studied parameters. No significant change in all biochemical parameters was noticed when the groups given the different formulations were compared with each other. The study concluded that administration of CO conventional emulsion, COM, or EM produced significant improvement in fatty liver and dyslipidemia with consequent expected protection from cardiovascular diseases and other complications of fatty liver. Formulation of CO in microemulsion having particle size similar to 8.0 nm did not enhance the protective effect compared with the same dose of CO dispersed in water as conventional macroemulsion, probably due to the ease of absorption of these bioactives in their native states. However, formulation in microemulsion provides a delivery system for oral administration of CO or eugenol in homogeneous, water-based, and thermodynamically stable dosage form during storage.
C1 [Al-Okbi, Sahar Y.; Mohamed, Doha A.; Hamed, Thanaa E.] Natl Res Ctr, Dept Food Sci & Nutr, Cairo 12622, Egypt.
   [Edris, Amr E.] Natl Res Ctr, Food Ind & Nutr Div, Cairo 12622, Egypt.
C3 Egyptian Knowledge Bank (EKB); National Research Centre (NRC); Egyptian
   Knowledge Bank (EKB); National Research Centre (NRC)
RP Edris, AE (corresponding author), Natl Res Ctr, El Behose St, Cairo 12622, Egypt.
EM amr_edris@hotmail.com
RI Mohamed, Doha/AAZ-2024-2020
OI Al-Okbi, Sahar Y./0000-0002-8114-2718; Mohamed,
   Doha/0000-0003-0606-9378; hamed, thanaa/0000-0002-5824-5356; Edris,
   Amr/0000-0001-8213-0770
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NR 53
TC 35
Z9 39
U1 0
U2 25
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1096-620X
EI 1557-7600
J9 J MED FOOD
JI J. Med. Food
PD JUL
PY 2014
VL 17
IS 7
BP 764
EP 771
DI 10.1089/jmf.2013.0033
PG 8
WC Chemistry, Medicinal; Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Food Science & Technology; Nutrition &
   Dietetics
GA AL5KO
UT WOS:000339172700005
PM 24611461
DA 2025-06-11
ER

PT J
AU Sun, CH
   Li, Y
   Zhang, YB
   Wang, F
   Zhou, XL
   Wang, F
AF Sun, C. -H.
   Li, Y.
   Zhang, Y. -B.
   Wang, F.
   Zhou, X. -L.
   Wang, F.
TI The effect of vitamin-mineral supplementation on CRP and IL-6: A
   systemic review and meta-analysis of randomised controlled trials
SO NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
LA English
DT Article
DE Atherogenesis; Vitamin; Mineral; Inflammation; Meta-analysis
ID C-REACTIVE PROTEIN; GAMMA-TOCOPHEROL SUPPLEMENTATION; FOLIC-ACID
   SUPPLEMENTATION; OXIDATIVE STRESS; OBESE-PATIENTS; ASCORBIC-ACID;
   INFLAMMATION; MARKERS; ATHEROSCLEROSIS; INTERVENTION
AB Background and Aims: Inflammation is regarded as a risk predictor for metabolic syndrome and atherogenesis. The objective of this study was to conduct a systematic review and a meta-analysis to confirm the effect of vitamin-mineral supplementation on cytokine levels.
   Methods and Results: We searched the PubMed, EMBASE and Cochrane databases up to May 2009 for randomised controlled trials regarding the effect of vitamin-mineral supplementation on C-reactive protein (CRP) and interleukin-6 (IL-6). Eighteen trials with 1747 participants for CRP and nine trials with 1037 participants for IL-6 were included, respectively. Pooled estimates and 95% confidence intervals (CIs) were calculated by fixed-or random-effects model. No significant differences were observed for CRP and IL-6 reduction between the subjects with vitamin-mineral supplementation and placebo control. A dose-dependent manner for different body mass index (BMI) subgroups in CRP analysis was observed (weighted mean difference (WMD), -0.057; 95% CI: -0.753 to 0.639 for BMI < 25; WMD, -0.426; 95% CI: -0.930 to 0.079 for 25 <= BMI < 30; WMD, -0.491; 95% CI: -1.407 to 0.424 for BMI >= 30). However, no significance was detected in meta-regression (-0.046, 95% CI: -0.135 to 0.044). Moreover, the best effect for reduction in CRP levels in a supplementation duration of 4 weeks-6 months (WMD, -0.449; 95%CI: -1.004 to 0.106) was observed compared with supplementation duration less than 4 weeks (WMD, -0.137; 95%CI, -0.816 to 0.541) and more than 6 months (WMD, -0.389; 95%CI, -1.034 to 0.257) without statistical significance (P = 0.059).
   Conclusion: No statistically significant evidences for the potential dose-dependent manner of BMI and best supplement duration were detected in this study. Large and well-designed studies are recommended to confirm this conclusion. (c) 2010 Elsevier B.V. All rights reserved.
C1 [Sun, C. -H.; Li, Y.; Wang, F.] Harbin Med Univ, Coll Publ Hlth, Dept Food Hyg & Nutr, Harbin 150086, Heilongjiang Pr, Peoples R China.
   [Zhang, Y. -B.] Harbin Med Univ, Coll Publ Hlth, Dept Environm Hyg, Harbin 150086, Heilongjiang Pr, Peoples R China.
   [Wang, F.] Harbin Med Univ, Coll Publ Hlth, Dept Epidemiol, Harbin 150086, Heilongjiang Pr, Peoples R China.
   [Zhou, X. -L.] Harbin Med Univ, Clin Coll 2, Harbin 150086, Heilongjiang Pr, Peoples R China.
C3 Harbin Medical University; Harbin Medical University; Harbin Medical
   University; Harbin Medical University
RP Sun, CH (corresponding author), Harbin Med Univ, Coll Publ Hlth, Dept Food Hyg & Nutr, Harbin 150086, Heilongjiang Pr, Peoples R China.
EM sun2002changhao@yahoo.com
RI Wang, Fan/I-6099-2019
OI Wang, Fan/0000-0002-9869-9504
FU Natural Science Foundation of China [30471445]; China's 11th Five-Year
   Scientific and Technical Plan [2006BAD27B05]
FX This work was supported by Natural Science Foundation of China (No.
   30471445), China's 11th Five-Year Scientific and Technical Plan (No.
   2006BAD27B05).
CR Ahmad SM, 2009, J NUTR, V139, P377, DOI 10.3945/jn.108.100198
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NR 37
TC 8
Z9 9
U1 0
U2 11
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0939-4753
EI 1590-3729
J9 NUTR METAB CARDIOVAS
JI Nutr. Metab. Carbiovasc. Dis.
PD AUG
PY 2011
VL 21
IS 8
BP 576
EP 583
DI 10.1016/j.numecd.2009.12.014
PG 8
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism; Nutrition
   & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism;
   Nutrition & Dietetics
GA 803QW
UT WOS:000293596800006
PM 20399082
DA 2025-06-11
ER

PT J
AU Mueller, AS
   Bosse, AC
   Most, E
   Klomann, SD
   Schneider, S
   Pallauf, J
AF Mueller, Andreas S.
   Bosse, Astrid C.
   Most, Erika
   Klomann, Sandra D.
   Schneider, Sandra
   Pallauf, Josef
TI Regulation of the insulin antagonistic protein tyrosine phosphatase 1B
   by dietary Se studied in growing rats
SO JOURNAL OF NUTRITIONAL BIOCHEMISTRY
LA English
DT Article
DE Selenium; Selenite; Selenate; PTP1B; Glutathionylation; Diabetes;
   Insulin resistance
ID ACTIVE-SITE CYSTEINE; GLUTATHIONE-PEROXIDASE; SELENIUM DEFICIENCY;
   IN-VIVO; MINERAL SUPPLEMENTS; METABOLIC SYNDROME; HYDROGEN-PEROXIDE;
   OXIDATIVE STRESS; REDOX REGULATION; MICE
AB Protein tyrosine phosphatase I R (PTP1B) is a key enzyme in the counterregulation of insulin signaling, and its physiological modulation depends on 11,0, and glutathione (GSH). Se via(NI peroxidases (GPxs) and its specific metabolism is involved in the removal OF 11202 and in the regulation of GSH I metabolism. Recent results, from animal trials and epidemiological studies with humans have shown that a high GPx1 activity or a permanent surplus of Se may promote the development of obesity and diabetes. Our nutrition physiological study with 7x7 growing rats was carried out to examine if PTP1B is modulated by Se supplements and, thus, may represent one trigger mediating these undesirable metabolic effects of Se. One group of rats was fed an Se-deficient diet for 8 weeks. The diets of the other six groups contained Se as selenite or selenate according to the recommendations (0.20 mg/kg diet) and at two supranutritional levels (1.00 and 2.00 mg/kg diet). All Se-supplemented animals featured a significantly higher body weight (6 14%) compared to their Se-deficient companions. Expression and activity of GPx1 in the liver of Se supplemented animals was 10- and 70-fold higher compared to Se deficiency. The detailed Study of PTP1B regulation using an enzymatic assay and Western Blot analysis with an antibody against protein glutathionylation revealed that PTP1B was significantly up-regUlated by both a maximization of GPx1 activity anti by increasing dietary SC Supply, reducing its, inhibition via glutathionylation. Selenate effected a stronger PTP activation compared to selenite. In Conclusion, our results suggest that the modulation of PTP1B activity may represent one plausible mechanism by which a long-term intake Of Se Supplements exceeding the requirements can Promote the development of obesity and diabetes and needs further intensive investigation. (C) 2009 Elsevier Inc. All rights reserved.
C1 [Mueller, Andreas S.; Bosse, Astrid C.; Most, Erika; Klomann, Sandra D.; Pallauf, Josef] Univ Giessen, Dept Anim Nutr & Nutrit Physiol, Interdisciplinary Res Ctr, D-35392 Giessen, Germany.
   [Mueller, Andreas S.] Univ Halle Wittenberg, Inst Agr & Nutrit Sci, Prevent Nutr Grp, D-06108 Halle, Germany.
   [Schneider, Sandra] Univ Giessen, Biotech Ctr, D-35392 Giessen, Germany.
C3 Justus Liebig University Giessen; Martin Luther University Halle
   Wittenberg; Justus Liebig University Giessen
RP Mueller, AS (corresponding author), Univ Giessen, Dept Anim Nutr & Nutrit Physiol, Interdisciplinary Res Ctr, D-35392 Giessen, Germany.
EM andreas.s.mueller@uni-giessen.de
FU H. Wilhelm Schaumann Foundation, Hamburg, Germany
FX The authors thank the H. Wilhelm Schaumann Foundation, Hamburg, Germany,
   for financial support and Dr. Rupert Schmidt (Biotechnical Centre) for
   advice on RTPCR experiments and on Western blot analysis.
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NR 65
TC 52
Z9 56
U1 0
U2 10
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0955-2863
EI 1873-4847
J9 J NUTR BIOCHEM
JI J. Nutr. Biochem.
PD APR
PY 2009
VL 20
IS 4
BP 235
EP 247
DI 10.1016/j.jnutbio.2008.02.007
PG 13
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA 424TY
UT WOS:000264592400001
PM 18602818
DA 2025-06-11
ER

PT J
AU Arsenescu, V
   Arsenescu, RI
   King, V
   Swanson, H
   Cassis, LA
AF Arsenescu, Violeta
   Arsenescu, Razvan I.
   King, Victoria
   Swanson, Hollie
   Cassis, Lisa A.
TI Polychlorinated biphenyl-77 induces adipocyte differentiation and
   proinflammatory adipokines and promotes obesity and atherosclerosis
SO ENVIRONMENTAL HEALTH PERSPECTIVES
LA English
DT Article
DE adipocyte differentiation; aryl hydrocarbon receptor; ectopic lipid
   deposition; obesity; polychlorinated biphenyl
ID PERSISTENT ORGANIC POLLUTANTS; VASCULAR ENDOTHELIAL-CELLS; INDUCED
   OXIDATIVE STRESS; 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN TCDD;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; ADIPOSE DIFFERENTIATION; SERUM
   CONCENTRATIONS; NONDIABETIC ADULTS; DIABETES-MELLITUS
AB BACKGROUND: Obesity, an inflammatory condition linked to cardiovascular disease, is associated with expansion of adipose tissue. Highly prevalent coplanar polychlorinated biphenyls (PCBs) such as 3,3',4,4'-tetrachlorobiphenyl (PCB-77) accumulate in adipose tissue because of their lipophilicity and increase with obesity. However, the effects of PCBs on adipocytes, obesity, and obesity-associated cardiovascular disease are unknown.
   OBJECTIVES: In this study we examined in vitro and in vivo effects of PCB-77 on adipocyte differentiation, proinflammatory adipokines, adipocyte morphology, body weight, serum lipids, and atherosclerosis.
   METHODS: PCB-77 or 2,2',4,4,5,5'-hexachlorobiphenyl (PCB-153) was incubated with 3T3-L1 adipocytes either during differentiation or in mature adipocytes. Concentration-dependent effects of PCB-77 were contrasted with those of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). For in vivo studies, we treated C57BL/6 wild-type (NW) or aryl hydrocarbon receptor (AhR)(-/-) mice with vehicle or PCB-77 (49 mg/kg, by intraperitoneal injection) and examined body weight gain. In separate studies, we injected ApoE(-/-) mice with vehicle or PCB-77 over a 6-week period and examined body weight, adipocyte size, serum lipids, and atherosclerosis.
   RESULTS: Low concentrations of PCB-77 or TCDD increased adipocyte differentiation, glycerol-3-phosphate dehydrogenase activity, and expression of peroxisome proliferator-activated receptor gamma, whereas higher concentrations inhibited adipocyte differentiation. Effects of PCB-77 were abolished by the AhR antagonist a-naphthoflavone. PCB-77 promoted the expression and release of various proinflammatory cytokines from 3T3-L1 adipocytes. Administration of PCB-77 increased body weight gain in WT but not AhR(-/-) mice. ApoE(-/-) mice injected with PCB-77 exhibited greater body weight, adipocyte hypertrophy, serum dyslipidemia, and augmented atherosclerosis.
   CONCLUSIONS: Our findings suggest that PCB-77 may contribute to the development of obesity and obesity-associated atherosclerosis.
C1 [Arsenescu, Violeta; King, Victoria; Cassis, Lisa A.] Univ Kentucky, Grad Ctr Nutr Sci, Room 521B,Wethington Bldg,900 S Limestone, Lexington, KY 40536 USA.
   [Arsenescu, Razvan I.] Univ Kentucky, Div Digest Dis & Nutr, Lexington, KY 40536 USA.
   [King, Victoria] Univ Kentucky, Cardiovasc Res Ctr, Lexington, KY 40536 USA.
   [Swanson, Hollie] Univ Kentucky, Dept Mol & Biomed Pharmacol, Lexington, KY 40536 USA.
C3 University of Kentucky; University of Kentucky; University of Kentucky;
   University of Kentucky
RP Cassis, LA (corresponding author), Univ Kentucky, Grad Ctr Nutr Sci, Room 521B,Wethington Bldg,900 S Limestone, Lexington, KY 40536 USA.
EM lcassis@uky.edu
RI Cassis, Lisa/G-1934-2011; arsenescu, razvan/K-3966-2014
OI Swanson, Hollie/0000-0002-3725-5504
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NR 49
TC 238
Z9 274
U1 4
U2 54
PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE
PI RES TRIANGLE PK
PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233,
   RES TRIANGLE PK, NC 27709-2233 USA
SN 0091-6765
EI 1552-9924
J9 ENVIRON HEALTH PERSP
JI Environ. Health Perspect.
PD JUN
PY 2008
VL 116
IS 6
BP 761
EP 768
DI 10.1289/ehp.10554
PG 8
WC Environmental Sciences; Public, Environmental & Occupational Health;
   Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health; Toxicology
GA 306NC
UT WOS:000256254100029
PM 18560532
OA Green Published, Green Accepted
DA 2025-06-11
ER

PT J
AU Saka, WA
   Oladipo, AA
   Kolawole, OR
   Olayioye, A
   Akhigbe, RE
AF Saka, W. A.
   Oladipo, A. A.
   Kolawole, O. R.
   Olayioye, A.
   Akhigbe, R. E.
TI Sexual dysfunction in dichlorvos-exposed male Wistar rat is ameliorated
   by curcumin and associated with the upregulation of testosterone
SO NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
LA English
DT Article
DE Aphrodisiac; Curcumin; Dichlorvos; Male infertility; Organophosphate;
   Sexual dysfunction
ID ERECTILE DYSFUNCTION; METABOLIC SYNDROME; OXIDATIVE STRESS
AB Dichlorvos is an organophosphate pesticide that is commonly used for agricultural and domestic control of pests and insects. Despite its usefulness, it exerts reproductive toxicity and induces male sexual dysfunction. On the other hand, curcumin has been reported to improve sexual dysfunction. However, till date, no study has reported the impact of curcumin on dichlorvos-induced sexual dysfunction. This study investigated the effect and associated mechanism of curcumin on dichlorvos-induced sexual dysfunction. Thirty-two male Wistar rats were randomized into four groups; the control (1 mL of olive oil), curcumin-treated (100 mg/kg), DDVP-treated (98.54 g/m(3) of dichlorvos by inhalation), and DDVP + Curcumin-treated. Dichlorvos induced sexual dysfunction as depicted by reduced motivation to mate (8.38 +/- 0.18 vs. 4.00 +/- 0.33, P < 0.0001), prolonged latencies (46.63 +/- 1.30 vs. 98.75 +/- 1.32, P < 0.0001) and reduced frequencies of mount (14.88 +/- 0.52 vs. 8.63 +/- 0.38), intromission (9.38 +/- 0.50 vs. 3.75 +/- 0.31, P < 0.0001), and ejaculation (7.63 +/- 0.38 vs. 1.50 +/- 0.19, P < 0.0001). These findings were accompanied by suppression of hypothalamic-pituitary-testicular axis, evidenced by marked reductions in circulating FSH (60.00 +/- 1.04 vs. 21.13 +/- 0.52, P < 0.0001), LH (46.38 +/- 1.38 vs. 19.00 +/- 0.46, P < 0.0001), and testosterone (6.01 +/- 0.50 vs. 0.74 +/- 0.05, P < 0.0001). Nonetheless, the administration of curcumin in dichlorvos-exposed rats significantly attenuated dichlorvos-induced sexual dysfunction by improving the assessed indices of male sexual act. Also, curcumin significantly increased serum levels of FSH (21.13 +/- 0.52 vs. 47.25 +/- 0.10, P < 0.0001), LH (19.00 +/- 0.46 vs. 43.00 +/- 1.49), and testosterone (0.74 +/- 0.05 vs. 3.98 +/- 0.08, P < 0.0001). This study revealed that curcumin attenuated dichlorvos-induced sexual dysfunction by activating the hypothalamic-pituitary-testicular axis and upregulating circulating testosterone.
C1 [Saka, W. A.; Oladipo, A. A.; Kolawole, O. R.; Akhigbe, R. E.] Ladoke Akintola Univ Technol, Dept Physiol, Ogbomosho, Oyo, Nigeria.
   [Oladipo, A. A.; Kolawole, O. R.; Akhigbe, R. E.] Oasis Grace Hosp, Reprod Biol & Toxicol Res Lab, Osogbo, Osun, Nigeria.
   [Olayioye, A.] Ladoke Akintola Univ Technol, Fac Agr Sci, Dept Crop & Environm Protect, Ogbomosho, Oyo, Nigeria.
RP Saka, WA (corresponding author), Ladoke Akintola Univ Technol, Dept Physiol, Ogbomosho, Oyo, Nigeria.
EM wsaka@lautech.edu.ng
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NR 65
TC 1
Z9 1
U1 0
U2 1
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0028-1298
EI 1432-1912
J9 N-S ARCH PHARMACOL
JI Naunyn-Schmiedebergs Arch. Pharmacol.
PD JAN
PY 2025
VL 398
IS 1
BP 1003
EP 1012
DI 10.1007/s00210-024-03333-y
EA AUG 2024
PG 10
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA U3C8V
UT WOS:001320140300001
PM 39096375
DA 2025-06-11
ER

PT J
AU Oba, K
   Tamura, Y
   Ishikawa, J
   Suzuki, H
   Fujiwara, Y
   Tachibana, A
   Kodera, R
   Toyoshima, K
   Chiba, Y
   Araki, A
AF Oba, Kazuhito
   Tamura, Yoshiaki
   Ishikawa, Joji
   Suzuki, Hiroyuki
   Fujiwara, Yoshinori
   Tachibana, Aya
   Kodera, Remi
   Toyoshima, Kenji
   Chiba, Yuko
   Araki, Atsushi
TI Dynapenic abdominal obesity is associated with mild cognitive impairment
   in patients with cardiometabolic disease: a cross-sectional study
SO BMC GERIATRICS
LA English
DT Article
DE Dynapenic abdominal obesity; Mild cognitive impairment; Handgrip
   strength; Waist circumference; Dynapenia; Cardiometabolic disease
ID BODY-MASS INDEX; INSULIN-RESISTANCE; METABOLIC SYNDROME; JAPANESE
   VERSION; LATE-LIFE; RISK; DEMENTIA; SARCOPENIA; INFLAMMATION;
   METAANALYSIS
AB Background Dementia is an important health issue for older people and requires early intervention in the mild cognitive impairment (MCI) stage to manage risk factors. Both dynapenia (DP) and abdominal obesity (AO) are associated with inflammation and oxidative stress, which may be involved in the pathogenesis of cognitive impairment. Therefore, in this cross-sectional study, we aimed to evaluate the association between MCI and dynapenic abdominal obesity (DAO), a combination of DP and AO. Methods A total of 417 older outpatients with cardiometabolic diseases without severe cognitive impairment were studied to compare cognitive function in four groups: control, DP, AO, and DAO groups. DAO was defined as the combination of DP (handgrip strength of < 28 kg and < 18 kg in men and women, respectively) and AO (waist circumference of >= 85 cm and >= 90 cm in men and women, respectively). MCI was defined as a score of <= 25 in the Japanese version of the Montreal Cognitive Assessment. Multiple regression analyses were performed to examine if MCI was independently associated with DAO, low handgrip strength, or high waist circumference. Results The DAO group obtained the lowest cognitive test scores and had the highest prevalence of MCI. Furthermore, after adjusting for covariates, the logistic regression analysis showed that patients in the DAO group were at an increased risk of MCI (odds ratio [OR] = 3.98, 95% confidence interval [CI]: 1.15-13.77). Further logistic regression analyses revealed that both low handgrip strength (OR = 2.19, 95% CI: 1.11-4.29) and high waist circumference (OR = 2.03, 95% CI: 1.03-3.99) were associated with MCI. Conclusions DAO, which can be easily diagnosed by a combination of handgrip strength and waist circumference, was associated with MCI in patents with cardiometabolic metabolic disease. This study suggests that screening for MCI in DAO patients could be important for early intervention of dementia prevention.
C1 [Oba, Kazuhito; Tamura, Yoshiaki; Tachibana, Aya; Kodera, Remi; Toyoshima, Kenji; Chiba, Yuko; Araki, Atsushi] Tokyo Metropolitan Geriatr Hosp, Dept Diabet Metab & Endocrinol, Itabashi Ku, 35-2 Sakae Cho, Tokyo 1730015, Japan.
   [Ishikawa, Joji] Tolyo Metropolitan Geriatr Hosp, Dept Ca Rdiol, Tokyo, Japan.
   [Suzuki, Hiroyuki; Fujiwara, Yoshinori] Tokyo Metropolitan Inst Gerontol, Res Team Social Participat & Community Hlth, Tokyo, Japan.
C3 Tokyo Metropolitan Institute of Gerontology; Tokyo Metropolitan
   Institute of Gerontology
RP Oba, K (corresponding author), Tokyo Metropolitan Geriatr Hosp, Dept Diabet Metab & Endocrinol, Itabashi Ku, 35-2 Sakae Cho, Tokyo 1730015, Japan.
EM kazuhito_oba@tmghig.jp
RI Araki, Atsushi/JVE-0081-2024
OI Araki, Atsushi/0000-0001-9088-2841; toyoshima, kenji/0000-0002-1220-273X
FU National Center for Geriatrics and Gerontology [28-30]
FX This study was supported by a grant from the Research Funding for
   Longevity Sciences (28-30) from the National Center for Geriatrics and
   Gerontology.
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NR 50
TC 11
Z9 12
U1 0
U2 2
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2318
J9 BMC GERIATR
JI BMC Geriatr.
PD MAR 28
PY 2022
VL 22
IS 1
AR 255
DI 10.1186/s12877-022-02948-1
PG 9
WC Geriatrics & Gerontology; Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA 0A4OB
UT WOS:000773934500001
PM 35346081
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Konwerski, M
   Gasecka, A
   Opolski, G
   Grabowski, M
   Mazurek, T
AF Konwerski, Michal
   Gasecka, Aleksandra
   Opolski, Grzegorz
   Grabowski, Marcin
   Mazurek, Tomasz
TI Role of Epicardial Adipose Tissue in Cardiovascular Diseases: A Review
SO BIOLOGY-BASEL
LA English
DT Article
DE atherosclerosis; cardiovascular diseases; epicardial adipose tissue;
   EAT; inflammation
ID TYPE-2 DIABETES-MELLITUS; CORONARY-ARTERY-DISEASE; GLUCAGON-LIKE
   PEPTIDE-1; C-REACTIVE PROTEIN; DIPEPTIDYL PEPTIDASE-4 INHIBITOR;
   PREVALENT ATRIAL-FIBRILLATION; HEART-FAILURE; STATIN THERAPY;
   INSULIN-RESISTANCE; PERICARDIAL FAT
AB Simple Summary Cardiovascular diseases (CVDs) are the leading causes of death worldwide. Epicardial adipose tissue (EAT) is one of the most important risk factors for cardiovascular events and a promising new therapeutic target in CVDs. Here, we summarize the currently available evidence regarding the role of EAT in the development of CVDs, including coronary artery disease, heart failure and atrial fibrillation; compile data regarding the association between EAT's function and the course of COVID-19; and present new potential therapeutic possibilities, aiming at modifying EAT's function. The development of novel therapies specifically targeting EAT could revolutionize the prognosis in CVDs. Cardiovascular diseases (CVDs) are the leading causes of death worldwide. Epicardial adipose tissue (EAT) is defined as a fat depot localized between the myocardial surface and the visceral layer of the pericardium and is a type of visceral fat. EAT is one of the most important risk factors for atherosclerosis and cardiovascular events and a promising new therapeutic target in CVDs. In health conditions, EAT has a protective function, including protection against hypothermia or mechanical stress, providing myocardial energy supply from free fatty acid and release of adiponectin. In patients with obesity, metabolic syndrome, or diabetes mellitus, EAT becomes a deleterious tissue promoting the development of CVDs. Previously, we showed an adverse modulation of gene expression in pericoronary adipose tissue in patients with coronary artery disease (CAD). Here, we summarize the currently available evidence regarding the role of EAT in the development of CVDs, including CAD, heart failure, and atrial fibrillation. Due to the rapid development of the COVID-19 pandemic, we also discuss data regarding the association between EAT and the course of COVID-19. Finally, we present the potential therapeutic possibilities aiming at modifying EAT's function. The development of novel therapies specifically targeting EAT could revolutionize the prognosis in CVDs.
C1 [Konwerski, Michal; Gasecka, Aleksandra; Opolski, Grzegorz; Grabowski, Marcin; Mazurek, Tomasz] Med Univ Warsaw, Chair & Dept Cardiol 1, PL-02097 Warsaw, Poland.
C3 Medical University of Warsaw
RP Mazurek, T (corresponding author), Med Univ Warsaw, Chair & Dept Cardiol 1, PL-02097 Warsaw, Poland.
EM konwerski.mich@gmail.com; aleksandra.gasecka@wum.edu.pl;
   grzegorz.opolski@wum.edu.pl; marcin.grabowski@wum.edu.pl;
   tmazurek@kardia.edu.pl
RI Mazurek, Tomasz/IMW-0840-2023; Grabowski, Marcin/M-3872-2018
OI Grabowski, Marcin/0000-0003-3306-0301; Opolski,
   Grzegorz/0000-0003-4744-2554; Gasecka, Aleksandra/0000-0001-5083-7587;
   Mazurek, Tomasz/0000-0002-3693-8741
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NR 243
TC 63
Z9 67
U1 0
U2 18
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2079-7737
J9 BIOLOGY-BASEL
JI Biology-Basel
PD MAR
PY 2022
VL 11
IS 3
AR 355
DI 10.3390/biology11030355
PG 24
WC Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics
GA 0D4RW
UT WOS:000775985400001
PM 35336728
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Gong, H
   Liu, Y
   Lyu, X
   Dong, LN
   Zhang, XY
AF Gong, Hui
   Liu, Yang
   Lyu, Xing
   Dong, Lini
   Zhang, Xiangyu
TI Lipoprotein subfractions in patients with sarcopenia and their relevance
   to skeletal muscle mass and function
SO EXPERIMENTAL GERONTOLOGY
LA English
DT Article
DE Lipoprotein subfraction; Sarcopenia; Vertical auto profile; Skeletal
   muscle mass
ID KOREA NATIONAL-HEALTH; ASIAN WORKING GROUP; METABOLIC SYNDROME;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; OBESITY; CHOLESTEROL;
   ASSOCIATIONS; PREVALENCE; DENSITY
AB Objective: Loss of skeletal muscle mass is a characteristic of aging. Growing evidence suggests the role of fatty acids and their derived lipid intermediates in the regulation of skeletal muscle and function. However, the exact association between lipoprotein subfractions and sarcopenia in elderly individuals remains unclear. In this study, we aimed to investigate the levels of lipoprotein subfractions in sarcopenia patients and their relationship with skeletal muscle mass and function.
   yMethods: A total of 84 elderly Chinese subjects aged >= 65 years who did not have diseases that obviously affected lipid metabolism were included. Concentrations of lipoprotein subfractions, including total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), HDL2, HDL3, low-density lipoprotein cholesterol (LDL-C), very low-density lipoprotein (VLDL), intermediate-density lipoprotein (IDL), VLDL3, LDL-particle (LDL-P), lipoprotein (a) and remnant-like particle cholesterol (RLP-C), were determined by vertical auto profile. Triglyceride (TG) was measured by an enzymatic colorimetric assay. The skeletal muscle index (SMI) was assessed by bioelectrical impedance analysis. Handgrip strength was measured using a hand-held dynamometer.
   Results: The levels of TC, TG, LDL-C, LDL-P, IDL, VLDL, VLDL3, RLP-C and C-reactive protein were significantly higher in sarcopenia patients than in controls (p < 0.05). Pearson Product-Moment Correlation Coefficient analysis showed that the TC, TG, LDL-C, IDL, VLDL, VLDL3, and RLP-C levels were negatively associated with the SMI; The TG, IDL, VLDL, VLDL3, and RLP-C were negatively correlated with handgrip strength. In multivariate stepwise regression analysis, the VLDL and RLP-C levels were significantly correlated with the SMI. The sensitivity and specificity of the combined measurement of VLDL and RLP-C in predicting sarcopenia were 69.8% and 92.5% (AUC: 0.831; 95% CI:(0.739, 0.924); p < 0.05).
   Conclusion: The occurrence of sarcopenia is associated with disorders of lipid metabolism, particularly VLDL and RLP-C.
C1 [Gong, Hui; Liu, Yang; Dong, Lini; Zhang, Xiangyu] Cent South Univ, Xiangya Hosp 2, Dept Geriatr, Changsha 410011, Hunan, Peoples R China.
   [Lyu, Xing] Cent South Univ, Xiangya Hosp 2, Lab Clin Med, Changsha 410011, Hunan, Peoples R China.
C3 Central South University; Central South University
RP Zhang, XY (corresponding author), Cent South Univ, Xiangya Hosp 2, Dept Geriatr, Changsha 410011, Hunan, Peoples R China.
EM xiangyuzhang@csu.edu.cn
RI Zhang, Xiangyu/JDW-3961-2023
FU National Natural Science Foundation of China [81470256]; Foundation
   Research Funds for the Central Universities of Central South University
   [2019zzts358]; Science and Technology Program Foundation of Changsha of
   China [kq2001040]
FX This work is supported by grants from the National Natural Science
   Foundation of China (81470256), the Foundation Research Funds for the
   Central Universities of Central South University (2019zzts358), and the
   Science and Technology Program Foundation of Changsha of China
   (kq2001040).
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NR 47
TC 34
Z9 36
U1 1
U2 24
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0531-5565
EI 1873-6815
J9 EXP GERONTOL
JI Exp. Gerontol.
PD MAR
PY 2022
VL 159
AR 111668
DI 10.1016/j.exger.2021.111668
EA DEC 2021
PG 6
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA YG7AJ
UT WOS:000742636200013
PM 34954281
DA 2025-06-11
ER

PT J
AU Cranmer-Byng, MM
   Liddle, DM
   De Boer, AA
   Monk, JM
   Robinson, LE
AF Cranmer-Byng, Mary M.
   Liddle, Danyelle M.
   De Boer, Anna A.
   Monk, Jennifer M.
   Robinson, Lindsay E.
TI Proinflammatory effects of arachidonic acid in a
   lipopolysaccharide-induced inflammatory microenvironment in 3T3-L1
   adipocytes in vitro
SO APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
LA English
DT Article
DE 3T3-L1 adipocytes; polyunsaturated fatty acids; n-3; n-6;
   lipopolysaccharide; adipokines; inflammation; obesity; endotoxemia
ID KAPPA-B PATHWAY; N-3 FATTY-ACIDS; HUMAN ADIPOSE-TISSUE;
   INSULIN-RESISTANCE; STEARIDONIC ACID; EICOSAPENTAENOIC ACID;
   PLASMA-CONCENTRATIONS; METABOLIC SYNDROME; OXIDATIVE STRESS; INNATE
   IMMUNITY
AB Long-chain n-3 polyunsaturated fatty acids (PUFA), eicosapentaenoic acid (20:5n-3, EPA) and docosahexaenoic acid (22:6n-3, DHA), have known anti-inflammatory effects, including the modulation of adipose tissue-derived inflammatory mediators (i.e., adipokines) implicated in obesity-related pathologies, such as insulin resistance. Less is known about the effects of plant-derived n-3 PUFA, alpha-linolenic acid (ALA, 18:3n-3) and stearidonic acid (SDA 18:4n-3), or n-6 PUFA linoleic acid (LA, 18:2n-6) and arachidonic acid (AA, 20:4n-6), especially in combination with an inflammatory stimulus, such as lipopolysaccharide (LPS), at a dose intended to mimic obesity-associated low-grade inflammation. To study this, 3T3-L1 adipocytes were incubated with 100 mu mol/L of various n-3 or n-6 PUFA with or without 10 ng/mL LPS for up to 24 h. AA in the presence of LPS synergistically increased (p < 0.05) pro-inflammatory monocyte chemoattractant protein-1 (MCP)-1 and interleukin (IL)-6 secretion and gene expression, as well as COX-2 and TLR2 gene expression at 6 and/or 24 h, suggesting their potential roles in the synergistic effects of AA and LPS. Plant-derived fatty acids ALA, SDA, and LA did not differentially affect adipokine gene expression or secretion, whereas LPS-induced pro-inflammatory IL-1 beta expression and MCP-1 secretion was decreased (p < 0.05) by EPA, DHA, and/or EPA+DHA (50 mu mol/L each) compared with LPS alone. Only DHA increased (p < 0.05) gene expression of the n-3 PUFA receptor GPR120 and simultaneously decreased LPS-induced nuclear factor-kappa B activation compared with control. Our findings emphasize that specific fatty acids within the n-3 or n-6 PUFA class warrant consideration in the development of nutritional strategies to improve obesity-associated inflammation.
C1 [Cranmer-Byng, Mary M.; Liddle, Danyelle M.; De Boer, Anna A.; Monk, Jennifer M.; Robinson, Lindsay E.] Univ Guelph, Dept Human Hlth & Nutr Sci, Guelph, ON N1G 2W1, Canada.
C3 University of Guelph
RP Robinson, LE (corresponding author), Univ Guelph, Dept Human Hlth & Nutr Sci, 336B Anim Sci & Nutr Bldg, Guelph, ON N1G 2W1, Canada.
EM lrobinso@uoguelph.ca
RI de Boer, Anna/KLZ-4721-2024
FU Natural Sciences and Engineering Research Council (NSERC); NSERC Canada
   Graduate Scholarship; Ontario Graduate Scholarship
FX This work was supported by a Natural Sciences and Engineering Research
   Council (NSERC) grant to L.E.R. M.M.C.-B. was supported by a NSERC
   Canada Graduate Scholarship and an Ontario Graduate Scholarship. D.M.L.
   and A.A.D. were supported by an Ontario Graduate Scholarship and a NSERC
   Postgraduate Scholarship, respectively.
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NR 52
TC 39
Z9 40
U1 1
U2 13
PU CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS
PI OTTAWA
PA 65 AURIGA DR, SUITE 203, OTTAWA, ON K2E 7W6, CANADA
SN 1715-5312
EI 1715-5320
J9 APPL PHYSIOL NUTR ME
JI Appl. Physiol. Nutr. Metab.
PD FEB
PY 2015
VL 40
IS 2
BP 142
EP 154
DI 10.1139/apnm-2014-0022
PG 13
WC Nutrition & Dietetics; Physiology; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics; Physiology; Sport Sciences
GA CA6LA
UT WOS:000349023800007
PM 25641170
DA 2025-06-11
ER

PT J
AU Yang, Y
   Pham, TX
   Wegner, CJ
   Kim, B
   Ku, CS
   Park, YK
   Lee, JY
AF Yang, Yue
   Pham, Tho X.
   Wegner, Casey J.
   Kim, Bohkyung
   Ku, Chai Siah
   Park, Young-Ki
   Lee, Ji-Young
TI Astaxanthin lowers plasma TAG concentrations and increases hepatic
   antioxidant gene expression in diet-induced obesity mice
SO BRITISH JOURNAL OF NUTRITION
LA English
DT Article
DE Astaxanthin; Non-alcoholic fatty liver disease;
   Hypotriacylglycerolaemia; Antioxidants; Diet-induced obesity mice
ID NONALCOHOLIC FATTY LIVER; BLUE-GREEN-ALGAE; KAPPA-B; CAROTENOID
   ASTAXANTHIN; METABOLIC SYNDROME; STELLATE CELLS; LIPID EXTRACT; HUMAN
   HEALTH; TGF-BETA; DISEASE
AB Non-alcoholic fatty liver disease (NAFLD) is significantly associated with hyperlipidaemia and oxidative stress. We have previously reported that astaxanthin (ASTX), a xanthophyll carotenoid, lowers plasma total cholesterol and TAG concentrations in apoE knockout mice. To investigate whether ASTX supplementation can prevent the development of NAFLD in obesity, male C57BL/6J mice (n 8 per group) were fed a high-fat diet (35 %, w/w) supplemented with 0, 0.003, 0.01 or 0.03% of ASTX (w/w) for 12 weeks. The 0.03% ASTX-supplemented group, but not the other groups, exhibited a significant decrease in plasma TAG concentrations, suggesting that ASTX at a 0.03% supplementation dosage exerts a hypotriacylglycerolaemic effect. Although there was an increase in the mRNA expression of fatty acid synthase and diglyceride acyltransferase 2, the mRNA levels of acyl-CoA oxidase 1, a critical enzyme in peroxisomal fatty acid beta-oxidation, exhibited an increase in the 0.03% ASTX-supplemented group. There was a decrease in plasma alanine transaminase (ALT) and aspartate transaminase (AST) concentrations in the 0.03% ASTX-supplemented group. There was a significant increase in the hepatic mRNA expression of nuclear factor erythroid 2-related factor 2 and its downstream genes, which are critical for endogenous antioxidant mechanism, in the 0.03% ASTX-supplemented group. Furthermore, there was a significant decrease in the mRNA abundance of IL-6 in the primary splenocytes isolated from the 0.03% ASTX-supplemented group upon lipopolysaccharide (LPS) stimulation when compared with that in the splenocytes isolated from the control group. In conclusion, ASTX supplementation lowered the plasma concentrations of TAG, ALT and AST, increased the hepatic expression of endogenous antioxidant genes, and rendered splenocytes less sensitive to LPS stimulation. Therefore, ASTX may prevent obesity-associated metabolic disturbances and inflammation.
C1 [Yang, Yue; Pham, Tho X.; Wegner, Casey J.; Kim, Bohkyung; Ku, Chai Siah; Park, Young-Ki; Lee, Ji-Young] Univ Connecticut, Dept Nutr Sci, Storrs, CT 06269 USA.
C3 University of Connecticut
RP Lee, JY (corresponding author), Univ Connecticut, Dept Nutr Sci, Storrs, CT 06269 USA.
EM ji-young.lee@uconn.edu
OI Yang, Yue/0000-0003-3116-3091; wegner, Casey/0000-0002-7785-2653; Yang,
   Yue/0000-0002-1481-8175
FU US Department of Agriculture AFRI [2012-67018-19290]; NIFA [578827,
   2012-67018-19290] Funding Source: Federal RePORTER
FX The present study was supported by the US Department of Agriculture AFRI
   (2012-67018-19290; to J.-Y. L).
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NR 46
TC 61
Z9 70
U1 3
U2 46
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1145
EI 1475-2662
J9 BRIT J NUTR
JI Br. J. Nutr.
PD DEC 14
PY 2014
VL 112
IS 11
BP 1797
EP 1804
DI 10.1017/S0007114514002554
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA AX7NH
UT WOS:000347102000006
PM 25328157
OA Bronze
DA 2025-06-11
ER

PT J
AU Vessiêres, E
   Guihot, AL
   Toutain, B
   Maquigneau, M
   Fassot, C
   Loufrani, L
   Henrion, D
AF Vessieres, Emilie
   Guihot, Anne-Laure
   Toutain, Bertrand
   Maquigneau, Maud
   Fassot, Celine
   Loufrani, Laurent
   Henrion, Daniel
TI COX-2-Derived Prostanoids and Oxidative Stress Additionally Reduce
   Endothelium-Mediated Relaxation in Old Type 2 Diabetic Rats
SO PLOS ONE
LA English
DT Article
ID MESENTERIC RESISTANCE ARTERIES; NITRIC-OXIDE SYNTHASE; BLOOD-FLOW;
   ANGIOTENSIN-II; KEY ROLE; INDUCED CONTRACTION; METABOLIC SYNDROME;
   DYSFUNCTION; ACTIVATION; OBESITY
AB Endothelial dysfunction in resistance arteries alters end organ perfusion in type 2 diabetes. Superoxides and cyclooxygenase-2 (COX-2) derivatives have been shown separately to alter endothelium-mediated relaxation in aging and diabetes but their role in the alteration of vascular tone in old diabetic subjects is not clear, especially in resistance arteries. Consequently, we investigated the role of superoxide and COX-2-derivatives on endothelium-dependent relaxation in 3 and 12 month-old Zucker diabetic fatty (ZDF) and lean (LZ) rats. Mesenteric resistance arteries were isolated and vascular tone was investigated using wire-myography. Endothelium (acetylcholine)-dependent relaxation was lower in ZDF than in LZ rats (60 versus 84% maximal relaxation in young rats and 41 versus 69% in old rats). Blocking NO production with L-NAME was less efficient in old than in young rats. L-NAME had no effect in old ZDF rats although eNOS expression level in old ZDF rats was similar to that in old LZ rats. Superoxide level and NADPH-oxidase subunits (p67phox and gp91phox) expression level were greater in ZDF than in LZ rats and were further increased by aging in ZDF rats. In young ZDF rats reducing superoxide level with tempol restored acetylcholine-dependent relaxation to the level of LZ rats. In old ZDF rats tempol improved acetylcholine-dependent relaxation without increasing it to the level of LZ rats. COX-2 (immunolabelling and Western-blot) was present in arteries of ZDF rats and absent in LZ rats. In old ZDF rats arterial COX-2 level was higher than in young ZDF rats. COX-2 blockade with NS398 restored in part acetylcholine-dependent relaxation in arteries of old ZDF rats and the combination of tempol and NS398 fully restored relaxation in control (LZ rats) level. Accordingly, superoxide production and COX-2 derivatives together reduced endothelium-dependent relaxation in old ZDF rats whereas superoxides alone attenuated relaxation in young ZDF or old LZ rats.
C1 [Vessieres, Emilie; Guihot, Anne-Laure; Toutain, Bertrand; Maquigneau, Maud; Fassot, Celine; Loufrani, Laurent; Henrion, Daniel] Univ Angers, Dept Integrated Neurovasc & Mitochondrial Biol, Angers, France.
   [Guihot, Anne-Laure; Loufrani, Laurent] CNRS, UMR 6214, Angers, France.
   [Fassot, Celine; Henrion, Daniel] INSERM, U1083, Angers, France.
   [Vessieres, Emilie; Henrion, Daniel] CHU Angers, Angers, France.
C3 Universite d'Angers; Centre National de la Recherche Scientifique
   (CNRS); Universite d'Angers; Institut National de la Sante et de la
   Recherche Medicale (Inserm); Universite d'Angers; Universite d'Angers;
   Centre Hospitalier Universitaire d'Angers
RP Henrion, D (corresponding author), Univ Angers, Dept Integrated Neurovasc & Mitochondrial Biol, Angers, France.
EM daniel.henrion@univ-angers.fr
RI loufrani, laurent/K-1713-2015; Henrion, Daniel/N-7023-2015; Toutain,
   Bertrand/M-1982-2015; vessieres, emilie/K-1894-2015; Fassot,
   Celine/K-1494-2015; Henrion, Daniel/J-8141-2015; Stefanadis,
   Christodoulos/ABH-2232-2020
OI Henrion, Daniel/0000-0003-1094-0285; Toutain,
   Bertrand/0000-0002-7571-4062; Stefanadis,
   Christodoulos/0000-0001-5974-6454
FU Foundation for Medical Research (FRM: Fondation pour la Recherche
   Medicale), Paris, France; Region Pays-de-la-Loire; Conseil General du
   Maine et Loire; Angers-Loire-Metropole
FX This work was supported in part by the Foundation for Medical Research
   (FRM: Fondation pour la Recherche Medicale), Paris, France; by the
   Region Pays-de-la-Loire; and by the Conseil General du Maine et Loire
   and by Angers-Loire-Metropole. The funders had no role in study design,
   data collection and analysis, decision to publish, or preparation of the
   manuscript.
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NR 66
TC 26
Z9 27
U1 0
U2 8
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JUL 9
PY 2013
VL 8
IS 7
AR e68217
DI 10.1371/journal.pone.0068217
PG 10
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 182JD
UT WOS:000321736900069
PM 23874545
OA gold, Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Xiao, WJ
   He, JW
   Zhang, H
   Hu, WW
   Gu, JM
   Yue, H
   Gao, G
   Yu, JB
   Wang, C
   Ke, YH
   Fu, WZ
   Zhang, ZL
AF Xiao, W-J
   He, J-W
   Zhang, H.
   Hu, W-W
   Gu, J-M
   Yue, H.
   Gao, G.
   Yu, J-B
   Wang, C.
   Ke, Y-H
   Fu, W-Z
   Zhang, Z-L
TI ALOX12 polymorphisms are associated with fat mass but not peak
   bone mineral density in Chinese nuclear families
SO INTERNATIONAL JOURNAL OF OBESITY
LA English
DT Article
DE ALOX12; fat mass; lean mass; peak bone mineral density; quantitative
   transmission disequilibrium test
ID BODY-MASS; ARACHIDONATE 12-LIPOXYGENASE; MOLECULAR-MECHANISM;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; OXIDATIVE STRESS; ACID
   REGULATION; CANINE BRAIN; GENE; OBESITY
AB Objective: Arachidonate 12-lipoxygenase (ALOX12) is a member of the lipoxygenase superfamily, which catalyzes the incorporation of molecular oxygen into polyunsaturated fatty acids. The products of ALOX12 reactions serve as endogenous ligands for peroxisome proliferator-activated receptor gamma (PPARG). The activation of the PPARG pathway in marrow-derived mesenchymal progenitors stimulates adipogenesis and inhibits osteoblastogenesis. Our objective was to determine whether polymorphisms in the ALOX12 gene were associated with variations in peak bone mineral density (BMD) and obesity phenotypes in young Chinese men.
   Methods: All six tagging single-nucleotide polymorphisms (SNPs) in the ALOX12 gene were genotyped in a total of 1215 subjects from 400 Chinese nuclear families by allele-specific polymerase chain reaction. The BMD at the lumbar spine and hip, total fat mass (TFM) and total lean mass (TLM) were measured using dual-energy X-ray absorptiometry. The pairwise linkage disequilibrium among SNPs was measured, and the haplotype blocks were inferred. Both the individual SNP markers and the haplotypes were tested for an association with the peak BMD, body mass index, TFM, TLM and percentage fat mass (PFM) using the quantitative transmission disequilibrium test (QTDT).
   Results: Using the QTDT, significant within-family association was found between the rs2073438 polymorphism in the ALOX12 gene and the TFM and PFM (P = 0.007 and 0.012, respectively). Haplotype analyses were combined with our individual SNP results and remained significant even after correction for multiple testing. However, we failed to find significant within-family associations between ALOX12 SNPs and the BMD at any bone site in young Chinese men.
   Conclusions: Our present results suggest that the rs2073438 polymorphism of ALOX12 contributes to the variation of obesity phenotypes in young Chinese men, although we failed to replicate the association with the peak BMD variation in this sample. Further independent studies are needed to confirm our findings. International Journal of Obesity (2011) 35, 378-386; doi:10.1038/ijo.2010.157; published online 10 August 2010
C1 [Xiao, W-J; He, J-W; Zhang, H.; Hu, W-W; Gu, J-M; Yue, H.; Gao, G.; Yu, J-B; Wang, C.; Ke, Y-H; Fu, W-Z; Zhang, Z-L] Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Dept Osteoporosis, Metab Bone Dis & Genet Res Unit, Shanghai 200233, Peoples R China.
C3 Shanghai Jiao Tong University
RP Zhang, ZL (corresponding author), Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Dept Osteoporosis, Metab Bone Dis & Genet Res Unit, 600 Yi-Shan Rd, Shanghai 200233, Peoples R China.
EM ZZL2002@medmail.com.cn
RI Hu, Wei-Wen/V-2617-2019; GAO, GAO/HLG-2473-2023
FU National Science Foundation of China (NSFC) [30570891, 30771019,
   30800387]; Program of Shanghai Chief Scientist [08XD1403000]
FX The study was supported by the National Science Foundation of China
   (NSFC) (No. 30570891, 30771019 and 30800387) and Program of Shanghai
   Chief Scientist (Project No. 08XD1403000).
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NR 49
TC 25
Z9 28
U1 0
U2 5
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0307-0565
EI 1476-5497
J9 INT J OBESITY
JI Int. J. Obes.
PD MAR
PY 2011
VL 35
IS 3
BP 378
EP 386
DI 10.1038/ijo.2010.157
PG 9
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 736IJ
UT WOS:000288486300008
PM 20697415
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Nov, O
   Kohl, A
   Lewis, EC
   Bashan, N
   Dvir, I
   Ben-Shlomo, S
   Fishman, S
   Wueest, S
   Konrad, D
   Rudich, A
AF Nov, Ori
   Kohl, Ayelet
   Lewis, Eli C.
   Bashan, Nava
   Dvir, Irit
   Ben-Shlomo, Shani
   Fishman, Sigal
   Wueest, Stephan
   Konrad, Daniel
   Rudich, Assaf
TI Interleukin-1β May Mediate Insulin Resistance in Liver-Derived Cells in
   Response to Adipocyte Inflammation
SO ENDOCRINOLOGY
LA English
DT Article
ID NECROSIS-FACTOR-ALPHA; HUMAN ADIPOSE-TISSUE; DIABETES-MELLITUS;
   MACROPHAGE INFILTRATION; RECEPTOR SUBSTRATE-1; METABOLIC SYNDROME;
   3T3-L1 ADIPOCYTES; OXIDATIVE STRESS; HUMAN OBESITY; UP-REGULATION
AB Central obesity is frequently associated with adipose tissue inflammation and hepatic insulin resistance. To identify potential individual mediators in this process, we used in vitro systems and assessed if insulin resistance in liver cells could be induced by secreted products from adipocytes preexposed to an inflammatory stimulus. Conditioned medium from 3T3-L1 adipocytes pretreated without (CM) or with TNF alpha (CM-TNF alpha) was used to treat Fao hepatoma cells. ELISAs were used to assess the concentration of several inflammatory mediators in CM-TNF alpha. CM-TNF alpha-treated Fao cells exhibited about 45% diminution in insulin-stimulated phosphorylation of insulin receptor, insulin receptor substrate proteins, protein kinase B, and glycogen synthase kinase-3 as compared with CM-treated cells, without changes in the total abundance of these protein. Insulin increased glycogenesis by 2-fold in CM-treated Fao cells but not in cells exposed to CM-TNF alpha. Expression of IL-1 beta mRNA was elevated 3-fold in TNF alpha-treated adipocytes, and CM-TNF alpha had 10-fold higher concentrations of IL-1 beta but not TNF alpha or IL-1 alpha. IL-1 beta directly induced insulin resistance in Fao, HepG2, and in primary rat hepatocytes. Moreover, when TNF alpha-induced secretion/production of IL-1 beta from adipocytes was inhibited by the IL-1 converting enzyme (ICE-1) inhibitor II (Ac-YVAD-CMK), insulin resistance was prevented. Furthermore, liver-derived cells treated with IL-1 receptor antagonist were protected against insulin resistance induced by CM-TNF alpha. Finally, IL-1 beta secretion from human omental fat explants correlated with body mass index (R(2) = 0.639, P < 0.01), and the resulting CM induced insulin resistance in HepG2 cells, inhibitable by IL-1 receptor antagonist. Our results suggest that adipocyte-derived IL-1 beta may constitute a mediator in the perturbed cross talk between adipocytes and liver cells in response to adipose tissue inflammation. (Endocrinology 151: 4247-4256, 2010)
C1 [Nov, Ori; Kohl, Ayelet; Lewis, Eli C.; Bashan, Nava; Rudich, Assaf] Ben Gurion Univ Negev, Fac Hlth Sci, Dept Clin Biochem, IL-84103 Beer Sheva, Israel.
   [Rudich, Assaf] Ben Gurion Univ Negev, Ctr Hlth & Nutr, Fac Hlth Sci, IL-84103 Beer Sheva, Israel.
   Ben Gurion Univ Negev, Natl Inst Biotechnol Negev, IL-84103 Beer Sheva, Israel.
   [Dvir, Irit] Sapir Acad Coll, Dept Ind Management, Chem & Life Sci Program, IL-79165 Dn Hof Ashkelon, Israel.
   [Ben-Shlomo, Shani; Fishman, Sigal] Tel Aviv Sourasky Med Ctr, Sackler Sch Med, Dept Gastroenterol & Hepatol, IL-69978 Tel Aviv, Israel.
   [Wueest, Stephan; Konrad, Daniel] Univ Childrens Hosp, Div Pediat Endocrinol & Diabetol, CH-8032 Zurich, Switzerland.
   [Wueest, Stephan; Konrad, Daniel] Univ Zurich, Zurich Ctr Integrat Human Physiol, CH-8057 Zurich, Switzerland.
C3 Ben-Gurion University of the Negev; Ben-Gurion University of the Negev;
   Ben-Gurion University of the Negev; Tel Aviv University; Sackler Faculty
   of Medicine; Tel Aviv Sourasky Medical Center; University Children's
   Hospital Zurich; University of Zurich; Zurich Center Integrative Human
   Physiology (ZIHP)
RP Rudich, A (corresponding author), Ben Gurion Univ Negev, Fac Hlth Sci, Dept Clin Biochem, IL-84103 Beer Sheva, Israel.
EM rudich@bgu.ac.il
RI LEWIS, ELI/F-1552-2012; RUDICH, ASSAF/MSY-8816-2025; Wueest,
   Stephan/H-9864-2012
OI Wuest, Stephan/0000-0002-0176-8906; Konrad, Daniel/0000-0001-9067-4356;
   Rudich, Assaf/0000-0002-1366-1444
FU Israel Science Foundation [1103-09]; Israeli Ministry of Health [3/5067]
FX This work was supported by a Grant 1103-09 from the Israel Science
   Foundation and Grant 3/5067 from the Israeli Ministry of Health (to
   A.R.).
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NR 47
TC 92
Z9 105
U1 0
U2 7
PU ENDOCRINE SOC
PI CHEVY CHASE
PA 8401 CONNECTICUT AVE, SUITE 900, CHEVY CHASE, MD 20815-5817 USA
SN 0013-7227
J9 ENDOCRINOLOGY
JI Endocrinology
PD SEP
PY 2010
VL 151
IS 9
BP 4247
EP 4256
DI 10.1210/en.2010-0340
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 642WP
UT WOS:000281252000021
PM 20660063
DA 2025-06-11
ER

PT J
AU Duncan, ER
   Walker, SJ
   Ezzat, VA
   Wheatcroft, SB
   Li, JM
   Shah, AM
   Kearney, MT
AF Duncan, Edward R.
   Walker, Simon J.
   Ezzat, Vivienne A.
   Wheatcroft, Stephen B.
   Li, Jian-Mei
   Shah, Ajay M.
   Kearney, Mark T.
TI Accelerated endothelial dysfunction in mild prediabetic insulin
   resistance: the early role of reactive oxygen species
SO AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
LA English
DT Article
DE insulin resistance; endothelial function; superoxide; enos
ID NITRIC-OXIDE SYNTHASE; HOMEOSTASIS MODEL ASSESSMENT; CARDIOVASCULAR
   RISK-FACTORS; CORONARY-HEART-DISEASE; OXIDATIVE STRESS; HYPERPOLARIZING
   FACTOR; METABOLIC SYNDROME; SUPEROXIDE-PRODUCTION; DIABETES-MELLITUS;
   VASCULAR-TONE
AB Insulin resistance is well established as an independent risk factor for the development of type 2 diabetes and cardiovascular atherosclerosis. Most studies have examined atherogenesis in models of severe insulin resistance or diabetes. However, by the time of diagnosis, individuals with type 2 diabetes already demonstrate a significant atheroma burden. Furthermore, recent studies suggest that, even in adolescence, insulin resistance is a progressive disorder that increases cardiovascular risk. In the present report, we studied early mechanisms of reduction in the bioavailability of the antiatheroscerotic molecule nitric oxide ( NO) in very mild insulin resistance. Mice with haploinsufficiency for the insulin receptor (IRKO) are a model of mild insulin resistance with preserved glycemic control. We previously demonstrated that 2-mo-old ( Young) IRKO mice have preserved vasorelaxation responses to ACh. This remained the case at 4 mo of age. However, by 6 mo, despite no significant deterioration in glucose homeostasis ( Adult), IRKO mice had marked blunting of ACh-mediated vasorelaxation [IRKO maximum contraction response ( E-max) 66 +/- 5% vs. wild type 87 +/- 4%, P < 0.01]. Despite the endothelial dysfunction demonstrated, aortic endothelial nitric oxide synthase ( eNOS) mRNA levels were similar in Adult IRKO and wild-type mice, and, interestingly, aortic eNOS protein levels were increased, suggesting a compensatory upregulation in the IRKO. We then examined the potential role of reactive oxygen species in mediating early endothelial dysfunction. The superoxide dismutase mimetic Mn(III) tetrakis(1-methyl-4-pyridyl) porphyrin pentachloride (MnTMPyP) restored ACh relaxation responses in the Adult IRKO ( Emax to ACh with MnTMPyP 85 +/- 5%). Dihydroethidium fluorescence of aortas and isolated coronary microvascular endothelial cells confirmed a substantial increase in endothelium-derived reactive oxygen species in IRKO mice. These data demonstrate that mild insulin resistance is a potent substrate for accelerated endothelial dysfunction and support a role for endothelial cell superoxide production as a mechanism underlying the early reduction in NO bioavailability.
C1 Univ Leeds, LIGHT Labs, Leeds Inst Genet Hlth & Therapeut, Leeds LS2 9JT, W Yorkshire, England.
   Kings Coll London, Sch Med, Div Cardiovasc, London WC2R 2LS, England.
   Univ Surrey, Sch Biomed & Mol Sci, Guildford GU2 5XH, Surrey, England.
C3 University of Leeds; University of London; King's College London;
   University of Surrey
RP Kearney, MT (corresponding author), Univ Leeds, LIGHT Labs, Leeds Inst Genet Hlth & Therapeut, Clarendon Way, Leeds LS2 9JT, W Yorkshire, England.
EM m.t.kearney@leeds.ac.uk
RI Shah, Amy/AAB-4631-2020
OI Shah, Ajay/0000-0002-6547-0631
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NR 59
TC 66
Z9 72
U1 0
U2 4
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0193-1849
EI 1522-1555
J9 AM J PHYSIOL-ENDOC M
JI Am. J. Physiol.-Endocrinol. Metab.
PD NOV
PY 2007
VL 293
IS 5
BP E1311
EP E1319
DI 10.1152/ajpendo.00299.2007
PG 9
WC Endocrinology & Metabolism; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Physiology
GA 229KA
UT WOS:000250800500023
PM 17711985
DA 2025-06-11
ER

PT J
AU Spina, A
   Guallar, E
   Rayman, MP
   Tigbe, W
   Kandala, NB
   Stranges, S
AF Spina, Alexander
   Guallar, Eliseo
   Rayman, Margaret P.
   Tigbe, William
   Kandala, Ngianga-Bakwin
   Stranges, Saverio
TI Anthropometric indices and selenium status in British adults: The UK
   National Diet and Nutrition Survey
SO FREE RADICAL BIOLOGY AND MEDICINE
LA English
DT Article
DE Selenium; Plasma selenium; Erythrocyte selenium; Glutathione peroxidase;
   Adiposity; Body mass index; Waist circumference; Waist-to-hip ratio;
   Oxidative stress; Free radicals
ID INCREASED OXIDATIVE STRESS; FOOD-CHAIN SELENIUM; SERUM SELENIUM; HUMAN
   HEALTH; GLUTATHIONE-PEROXIDASE; METABOLIC SYNDROME; US ADULTS; OBESITY;
   RISK; DETERMINANTS
AB Recent studies have raised concern over possible associations between high selenium (Se) status and excess adiposity, known to be linked to adverse cardiometabolic outcomes. Studies of Se status in relation to adiposity are scarce in the United Kingdom. This study examined cross-sectional associations of anthropometric indices with Se-status biomarkers in a nationally representative sample of 1045 (577 female, 468 male) British Caucasian adults ages 19-64 who participated in the 2000-2001 National Diet and Nutrition Survey. Median (first, third quartile) values for whole-blood glutathione peroxidase (GPx) activity and plasma and erythrocyte Se concentrations were 120.0 (103.0, 142.4) nmol mg Hb(-1) min(-1), 1.08 (0.98, 1.20) mu mol/L, and 1.62 (1.38, 1.91) mu mol/L, respectively. For males, values were 119.0 (100.0, 141.0) nmol mg Hb(-1) min(-1), 1.09 (0.99, 1.22) mu mol/L, and 1.54 (1.34, 1.79) mu mol/L, respectively; for females 121.0 (105.0, 145.0) nmol mg Hb(-1) min(-1), 1.07 (0.97, 1.18) mu mol/L, and 1.71 (1.43, 1.99) mu mol/L, respectively. Multivariate adjusted mean differences (95% CI) in whole-blood GPx between the highest (> 30 kg/m(2)) and the lowest (< 25 kg/m(2)) categories of body mass index and the highest (96.5-139.2 cm) and the lowest (52.2-78.1 cm) quartiles of waist circumference (WC) were -7.9 (-13.2, -2.7) and -9.7 (-16.2, -3.2) nmol mg Hb(-1) min(-1), respectively. Difference (95% CI) in plasma Se between the third (87.5-96.4 cm) and the lowest quartiles of WC was -0.04 (-0.08, -0.03) mu mol/L. Difference (95% CI) in red blood cell (RBC) Se between the highest (0.91-1.11) and the lowest (0.53-0.76) quartiles of waist-to-hip ratio (WHR) was 0.10 (0.00, 0.20) mu mol/L. Similar results were observed us gender and menopausal-status subgroup analyses. The inverse association between plasma Se and WC and the positive association between RBC Se and WHR will need confirmation. The findings suggest associations between low whole-blood GPx activity and higher measures of general and central adiposity. Further experimental and randomized studies are needed to deduce the mechanisms and infer causality. (C) 2013 Elsevier Inc. All rights reserved.
C1 [Spina, Alexander; Tigbe, William; Kandala, Ngianga-Bakwin; Stranges, Saverio] Univ Warwick, Sch Med, Div Hlth Sci, Coventry CV4 7AL, W Midlands, England.
   [Guallar, Eliseo] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD 21205 USA.
   [Guallar, Eliseo] Johns Hopkins Bloomberg Sch Publ Hlth, Welch Ctr Prevent Epidemiol & Clin Res, Baltimore, MD 21205 USA.
   [Rayman, Margaret P.] Univ Surrey, Fac Hlth & Med Sci, Guildford GU2 7XH, Surrey, England.
   [Kandala, Ngianga-Bakwin] Univ Oxford, KEMRI, Ctr Geog Med, Malaria Publ Hlth & Epidemiol Grp,Wellcome Trust, Nairobi, Kenya.
C3 University of Warwick; Johns Hopkins University; Johns Hopkins Bloomberg
   School of Public Health; Johns Hopkins University; Johns Hopkins
   Bloomberg School of Public Health; University of Surrey
RP Stranges, S (corresponding author), Univ Warwick, Sch Med, Div Hlth Sci, Coventry CV4 7AL, W Midlands, England.
EM S.Stranges@warwick.ac.uk
RI Stranges, Saverio/F-3273-2010; Guallar, Eliseo/D-3807-2014; Kandala,
   Ngiianga-Bakwin/JVP-0158-2024; Rayman, Margaret/HPC-1602-2023
OI Spina, Alexander/0000-0001-8425-1867; Stranges,
   Saverio/0000-0001-5226-8373; Kandala, Ngianga-Bakwin/0000-0002-5654-5486
CR [Anonymous], 41 COMM MED ASP FOOD
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NR 58
TC 34
Z9 37
U1 0
U2 16
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0891-5849
EI 1873-4596
J9 FREE RADICAL BIO MED
JI Free Radic. Biol. Med.
PD DEC
PY 2013
VL 65
BP 1315
EP 1321
DI 10.1016/j.freeradbiomed.2013.09.025
PG 7
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 278DI
UT WOS:000328868900126
PM 24095852
DA 2025-06-11
ER

PT J
AU Giannoulaki, P
   Kotzakioulafi, E
   Nakas, A
   Kontoninas, Z
   Karlafti, E
   Evripidou, P
   Kantartzis, K
   Savopoulos, C
   Chourdakis, M
   Didangelos, T
AF Giannoulaki, Parthena
   Kotzakioulafi, Evangelia
   Nakas, Alexandros
   Kontoninas, Zisis
   Karlafti, Eleni
   Evripidou, Polykarpos
   Kantartzis, Konstantinos
   Savopoulos, Christos
   Chourdakis, Michail
   Didangelos, Triantafyllos
TI Effect of Crocus sativus Extract Supplementation in the Metabolic
   Control of People with Diabetes Mellitus Type 1: A Double-Blind
   Randomized Placebo-Controlled Trial
SO NUTRIENTS
LA English
DT Article
DE diabetes mellitus type 1; continuous glucose monitoring; probiotics;
   saffron extract; Crocus sativus L.
ID SAFETY EVALUATION; LIPID PROFILE; SAFFRON; PARAMETERS; RESISTANCE;
   DISTRESS; TABLETS; RATS
AB Introduction-Background: Data from experimental trials show that Crocus sativus L. (saffron) is considered to improve glycemia, lipid profile, and blood pressure and reduce oxidative stress. So far, clinical trials have been conducted in individuals with metabolic syndrome and Diabetes Mellitus type 2 (DMT-2). The purpose of this study is to assess the effectiveness of saffron in individuals with Diabetes Mellitus type 1 (DMT-1). Patients-Methods: 61 individuals with DMT-1, mean age 48 years old (48.3 +/- 14.6), 26 females (42.6%) were randomized to receive a new oral supplement in sachets containing probiotics, prebiotics, magnesium, and Crocus sativus L. extract or placebo containing probiotics, prebiotics and magnesium daily for 6 months. Glycemic control was assessed with a continuous glucose monitoring system and laboratory measurement of HbA1c and lipid profile was also examined. Blood pressure at baseline and end of intervention was also measured. Individuals were either on a continuous subcutaneous insulin infusion with an insulin pump or in multiple daily injection regimens. Diabetes distress and satiety were assessed through a questionnaire and body composition was assessed with bioelectrical impedance. Results: At the end of the intervention, the two groups differed significantly only in serum triglycerides (p = 0.049). After 6 months of treatment, a significant reduction in the active group was observed in glycated hemoglobin (p = 0.046) and serum triglycerides (p = 0.021) compared to baseline. The other primary endpoints (glycemic control, lipid profile, blood pressure) did not differ within the groups from baseline to end of intervention, and there was no significant difference between the two groups. Diabetes distress score improved significantly only in the active group (p = 0.044), suggesting an overall improvement in diabetes disease burden in these individuals but that was not significant enough between the two groups. Conclusions: A probiotic supplement with saffron extract improves serum triglycerides in well-controlled people with DMT-1 and may potentially be a valuable adjunct for enhancing glycemic control.
C1 [Giannoulaki, Parthena] Univ Gen Hosp Thessaloniki AHEPA, Dept Clin Nutr, Thessaloniki 54636, Greece.
   [Giannoulaki, Parthena; Kotzakioulafi, Evangelia; Nakas, Alexandros; Kontoninas, Zisis; Karlafti, Eleni; Evripidou, Polykarpos; Savopoulos, Christos; Didangelos, Triantafyllos] Aristotle Univ Thessaloniki, Univ Gen Hosp Thessaloniki AHEPA, Diabet Ctr, Sch Med,Propaedeut Dept Internal Med 1st, Thessaloniki 54636, Greece.
   [Kantartzis, Konstantinos] Univ Tubingen, Dept Internal Med 4, Div Endocrinol Diabetol & Nephrol, D-72076 Tubingen, Germany.
   [Kantartzis, Konstantinos] Univ Tubingen, Inst Diabet Res & Metab Dis IDM, Helmholtz Ctr Munich, D-72076 Tubingen, Germany.
   [Kantartzis, Konstantinos] German Ctr Diabet Res DZD, D-72076 Tubingen, Germany.
   [Chourdakis, Michail] Aristotle Univ Thessaloniki, Fac Hlth Sci, Sch Med, Lab Hyg Social & Prevent Med & Med Stat, Thessaloniki 54124, Greece.
C3 Aristotle University of Thessaloniki; Ahepa University Hospital;
   Aristotle University of Thessaloniki; Ahepa University Hospital;
   Eberhard Karls University of Tubingen; Helmholtz Association;
   Helmholtz-Center Munich - German Research Center for Environmental
   Health; Eberhard Karls University of Tubingen; German Center for
   Diabetes Research (DZD); Aristotle University of Thessaloniki
RP Giannoulaki, P (corresponding author), Univ Gen Hosp Thessaloniki AHEPA, Dept Clin Nutr, Thessaloniki 54636, Greece.; Giannoulaki, P (corresponding author), Aristotle Univ Thessaloniki, Univ Gen Hosp Thessaloniki AHEPA, Diabet Ctr, Sch Med,Propaedeut Dept Internal Med 1st, Thessaloniki 54636, Greece.
EM nenagian@yahoo.com; ekotzaki@auth.gr; al.nakas@hotmail.com;
   drziko2401@gmail.com; linakarlafti@hotmail.com;
   polysevripidou@gmail.com; konstantinos.kantartzis@med.uni-tuebingen.de;
   csavvopo@auth.gr; mhourd@gapps.auth.gr; didang@auth.gr
RI Kantartzis, Konstantinos/AAC-3999-2019; KONTONINAS, ZISIS/NGR-5407-2025;
   Kotzakioulafi, Evangelia/AAY-1890-2020
OI Giannoulaki, Parthena/0000-0002-9413-6368; Kotzakioulafi,
   Evangelia/0000-0003-4841-1928; Kantartzis,
   Konstantinos/0000-0002-0584-1138
FX We would like to thank Tseti K. Ioulia, Uni-Pharma S.A., Athens, Greece,
   for the provision of supplements to our study and Zardeli Afrodite for
   the dietary data analysis.
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NR 51
TC 2
Z9 2
U1 2
U2 3
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JUL
PY 2024
VL 16
IS 13
AR 2089
DI 10.3390/nu16132089
PG 14
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA YJ6U5
UT WOS:001268169400001
PM 38999837
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Nishiyama, Y
   Otsuka, T
   Kato, K
   Saiki, Y
   Matsumoto, N
   Kimura, K
AF Nishiyama, Yasuhiro
   Otsuka, Toshiaki
   Kato, Katsuhito
   Saiki, Yoshiyuki
   Matsumoto, Noriko
   Kimura, Kazumi
TI Intima-Media Thickness in the Carotid Bifurcation is Related to Silent
   Brain Infarction: A Cross-Sectional Study
SO JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
LA English
DT Article
DE Carotid bifurcation; Carotid intima-media thickness; Cross-sectional
   study; Medical check-up; Silent brain infarction
ID CARDIOVASCULAR RISK-FACTORS; PREDICTED STROKE RISK; ASYMMETRIC
   DIMETHYLARGININE; MYOCARDIAL-INFARCTION; METABOLIC SYNDROME;
   ARTERIAL-WALL; SHEAR-STRESS; ATHEROSCLEROSIS; DISEASE; ULTRASOUND
AB Aims: Carotid intima-media thickness (IMT) measurement is used to assess subclinical atherosclerosis. We aimed to examine the association between the maximum IMT by location and the occurrence of silent brain Methods: Overall, 280 Japanese individuals (92 females, 52.6 +/- 5 years old) underwent a medical check-up at our hospital in Tokyo in 2015. Carotid IMT was measured at each site on ultrasound images (common carotid artery [CCA], internal carotid artery, or bifurcation). The risk factors for arterial dysfunction were evaluated. SBI was assessed using magnetic resonance imaging (MRI). The cross-sectional relationship between carotid maximum IMT and SBI was evaluated. Results: Of the 280 individuals, 18 (6.4%) were diagnosed with SBI on MRI. The mean age of the SBI(-) and SBI(+) groups was 51.9 +/- 10.6 and 63.6 +/- 18.6 years, respectively. The correlation coefficients between the carotid maximum IMT at each location were very weak (correlation coefficient range: 0.180-0.253). The percentage of participants with SBI increased significantly with increasing maximum CCA and bIMT values. After adjusting for confounders, SBI was found to be significantly associated with the maximum bIMT (per 0.1-mm increase) (adjusted odds ratio [aOR], 1.10; 95% confidence interval [CI]: 1.03-1.17). When bIMT was categorized according to three groups (<1.0 mm, 1.0-<2.0 mm, and >= 2.0 mm), a significant SBI risk was also observed with an increase by each category of bIMT (aOR: 3.96, 95% CI: 1.63-9.52, P=0.002). Conclusion: The maximum bIMT was found to be the main determinant of SBI. A significant SBI risk was associated with an increase in each category of the maximum bIMT. Therefore, the maximum bIMT might be a useful predictor of future stroke in Japanese stroke-free medical check-up participants.
C1 [Nishiyama, Yasuhiro; Matsumoto, Noriko; Kimura, Kazumi] Nippon Med Sch, Grad Sch Med, Dept Neurol, 1-1-5 Sendagi,Bunkyo Ku, Tokyo 1138602, Japan.
   [Otsuka, Toshiaki; Kato, Katsuhito; Saiki, Yoshiyuki] Nippon Med Sch, Grad Sch Med, Dept Hyg & Publ Hlth, Tokyo, Japan.
C3 Nippon Medical School; Nippon Medical School
RP Nishiyama, Y (corresponding author), Nippon Med Sch, Grad Sch Med, Dept Neurol, 1-1-5 Sendagi,Bunkyo Ku, Tokyo 1138602, Japan.
EM nomo16@nms.ac.jp
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NR 50
TC 1
Z9 1
U1 0
U2 0
PU JAPAN ATHEROSCLEROSIS SOC
PI TOKYO
PA NICHINAI-KAIKAN B1, 3-28-8 HONGO BUNKYO-KU, TOKYO, 113-0033, JAPAN
SN 1340-3478
EI 1880-3873
J9 J ATHEROSCLER THROMB
JI J. Atheroscler. Thromb.
PY 2024
VL 31
IS 9
BP 1293
EP 1303
DI 10.5551/jat.64721
EA MAR 2024
PG 11
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA E5I6Y
UT WOS:001203669500001
PM 38447967
OA gold
DA 2025-06-11
ER

PT J
AU Hyun, J
   Al Abo, M
   Dutta, RK
   Oh, SH
   Xiang, K
   Zhou, XY
   Maeso-Díaz, R
   Caffrey, R
   Sanyal, AJ
   Freedman, JA
   Patierno, SR
   Moylan, CA
   Abdelmalek, MF
   Diehl, AM
AF Hyun, Jeongeun
   Al Abo, Muthana
   Dutta, Rajesh Kumar
   Oh, Seh Hoon
   Xiang, Kun
   Zhou, Xiyou
   Maeso-Diaz, Raquel
   Caffrey, Rebecca
   Sanyal, Arun J.
   Freedman, Jennifer A.
   Patierno, Steven R.
   Moylan, Cynthia A.
   Abdelmalek, Manal F.
   Diehl, Anna Mae
TI Dysregulation of the ESRP2-NF2-YAP/TAZ axis promotes hepatobiliary
   carcinogenesis in non-alcoholic fatty liver disease
SO JOURNAL OF HEPATOLOGY
LA English
DT Article
DE epithelial splicing regulatory protein-2 (ESRP2); neurofibromatosis-2
   (NF2); hippo kinase; alternative RNA splicing; nonalcoholic fatty liver
   disease (NAFLD); hepatocellular carcinoma (HCC); liver cancer;
   yes-associated protein (YAP)
ID HEPATOCELLULAR-CARCINOMA; TGF-BETA; CANCER; YAP; INFLAMMATION;
   EXPRESSION; FIBROSIS; HEPATOCARCINOGENESIS; HOMEOSTASIS; MECHANISMS
AB Background & Aims: Non-alcoholic fatty liver disease (NAFLD), the hepatic correlate of the metabolic syndrome, is a major risk factor for hepatobiliary cancer (HBC). Although chronic inflam-mation is thought to be the root cause of all these diseases, the mechanism whereby it promotes HBC in NAFLD remains poorly understood. Herein, we aim to evaluate the hypothesis that inflammation-related dysregulation of the ESRP2-NF2-YAP/TAZ axis promotes HB carcinogenesis.
   Methods: We use murine NAFLD models, liver biopsies from patients with NAFLD, human liver cancer registry data, and studies in liver cancer cell lines.
   Results: Our results confirm the hypothesis that inflammation related dysregulation of the ESRP2-NF2-YAP/TAZ axis promotes HB carcinogenesis, supporting a model whereby chronic inflammation suppresses hepatocyte expression of ESRP2, an RNA splicing factor that directly targets and activates NF2, a tumor suppressor that is necessary to constrain YAP/TAZ activation. The resultant loss of NF2 function permits sustained YAP/ TAZ activity that drives hepatocyte proliferation and dedifferentiation.
   Conclusion: Herein, we report on a novel mechanism by which chronic inflammation leads to sustained activation of YAP/TAZ activity; this imposes a selection pressure that favors liver cells with mutations enabling survival during chronic oncogenic stress.
   Lay summary: Non-alcoholic fatty liver disease (NAFLD) increases the risk of hepatobiliary carcinogenesis. However, the underlying mechanism remains unknown. Our study demonstrates that chronic inflammation suppresses hepatocyte expression of ESRP2, an adult RNA splicing factor that activates NF2. Thus, inactive (fetal) NF2 loses the ability to activate Hippo kinases, leading to the increased activity of downstream YAP/TAZ and promoting hepatobiliary carcinogenesis in chronically injured livers. (C) 2021 The Author(s). Published by Elsevier B.V. on behalf of European Association for the Study of the Liver.
C1 [Hyun, Jeongeun; Dutta, Rajesh Kumar; Oh, Seh Hoon; Zhou, Xiyou; Maeso-Diaz, Raquel; Freedman, Jennifer A.; Patierno, Steven R.; Moylan, Cynthia A.; Abdelmalek, Manal F.; Diehl, Anna Mae] Duke Univ, Dept Med, Duke Univ Hlth Syst, Durham, NC USA.
   [Hyun, Jeongeun] Duke Univ, Sch Med, Regenerat Next, Durham, NC USA.
   [Hyun, Jeongeun] Dankook Univ, Inst Tissue Regenerat Engn ITREN, Cheonan, South Korea.
   [Hyun, Jeongeun] Dankook Univ, Dept Nanobiomed Sci, Cheonan, South Korea.
   [Hyun, Jeongeun] Dankook Univ, BK21 Plus NBM Global Res Ctr Regenerat Med, Cheonan, South Korea.
   [Hyun, Jeongeun] Dankook Univ, Coll Dent, Dept Regenerat Dent Med, Cheonan, South Korea.
   [Al Abo, Muthana; Freedman, Jennifer A.; Patierno, Steven R.] Duke Univ, Duke Canc Inst, Sch Med, Durham, NC USA.
   [Xiang, Kun] Duke Univ, Dept Biomed Engn, Pratt Sch Engn, Durham, NC 27706 USA.
   [Caffrey, Rebecca] Sanyal Biotechnol LLC, Norfolk, VA USA.
   [Sanyal, Arun J.] Virginia Commonwealth Univ, Dept Internal Med, Div Gastroenterol Hepatol & Nutr, Richmond, VA USA.
C3 Duke University; Duke University; Dankook University; Dankook
   University; Dankook University; Dankook University; Duke University;
   Duke University; Virginia Commonwealth University
RP Diehl, AM (corresponding author), 905 S LaSalle St,GSRB 1,Suite 1073, Durham, NC 27710 USA.
EM annamae.diehl@duke.edu
RI Moylan, Cynthia/JEF-9789-2023; Dutta, Rajesh/J-7790-2019; Abdelmalek,
   Manal/AAW-2203-2020; Maeso Diaz, Raquel/K-4766-2015
OI Al Abo, Muthana/0000-0001-6028-3688; Hyun, Jeongeun/0000-0003-1144-2552;
   Dutta, Rajesh Kumar/0000-0002-1394-0961; Moylan,
   Cynthia/0000-0001-8454-7086; Maeso Diaz, Raquel/0000-0002-2448-0251
FU NIH [DK106633, AA010154, DK077794]; Florence McAlister Professorship of
   Medicine; Duke Regeneration Next Initiative; NRF of Korea
   [2021R1C1C1003904]; DoD Prostate Cancer Research Program Health
   Disparity Research Award [PC131972, PC180980]; NIH Feasibility Studies
   to Build Collaborative Partnerships in Cancer Research P20 Award
   [1P20-CA20292501A1]; NIH Basic Research in Cancer Health Disparities R01
   Award [R01CA220314]; Prostate Cancer Foundation Movember Challenge Award
   [18CHAL04]; DoD Lung Cancer Research Program Idea Development Award -New
   Investigator [LC190367]; National Cancer Institute [R01CA220314] Funding
   Source: NIH RePORTER
FX This work was supported by NIH grants DK106633, AA010154, DK077794 and
   The Florence McAlister Professorship of Medicine to AMD, and a postdoc
   fellowship from the Duke Regeneration Next Initiative and NRF of Korea
   2021R1C1C1003904 to JH. This work was partially supported by a DoD
   Prostate Cancer Research Program Health Disparity Research Award
   PC131972 to SRP PI and JAF Co-I, a NIH Feasibility Studies to Build
   Collaborative Partnerships in Cancer Research P20 Award
   1P20-CA20292501A1 to SRP Overall PI and JAF PI of Pilot Project One, a
   NIH Basic Research in Cancer Health Disparities R01 Award R01CA220314 to
   SRP PI and JAF Co-I, a Prostate Cancer Foundation Movember Challenge
   Award #18CHAL04 to SRP and JAF Multi-PI and MA YI, a DoD Prostate Cancer
   Research Program Health Disparity Research Award PC180980 to JAF and SRP
   Co-I, and a DoD Lung Cancer Research Program Idea Development Award -New
   Investigator LC190367 to JAF PI.
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NR 46
TC 38
Z9 39
U1 1
U2 31
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0168-8278
EI 1600-0641
J9 J HEPATOL
JI J. Hepatol.
PD SEP
PY 2021
VL 75
IS 3
BP 623
EP 633
DI 10.1016/j.jhep.2021.04.033
EA AUG 2021
PG 12
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA UD1MC
UT WOS:000686978100012
PM 33964370
OA hybrid, Green Accepted
DA 2025-06-11
ER

PT J
AU Banaszak, M
   Górna, I
   Przyslawski, J
AF Banaszak, Michalina
   Gorna, Ilona
   Przyslawski, Juliusz
TI Zinc and the Innovative Zinc-α2-Glycoprotein Adipokine Play an Important
   Role in Lipid Metabolism: A Critical Review
SO NUTRIENTS
LA English
DT Review
DE zinc; zinc-alpha 2-glycoprotein; lipid metabolism
ID SUBCUTANEOUS ADIPOSE-TISSUE; INSULIN-RESISTANCE; MOBILIZING FACTOR;
   OXIDATIVE STRESS; SERUM ZINC-ALPHA-2-GLYCOPROTEIN; ALPHA2 GLYCOPROTEIN;
   LIGAND-BINDING; TRACE-ELEMENTS; OBESE WOMEN; BODY-WEIGHT
AB Numerous studies indicate that zinc and the new zinc-related adipokine, zinc-alpha 2-glycoprotein (ZAG), are involved in lipid metabolism. Excess body fat lowers blood concentrations of Zn and ZAG, leading not only to the development of obesity but also to other components of the metabolic syndrome. Zinc homeostasis disorders in the body negatively affect the lipid profile and cytokine secretion. Zinc appears to be a very important ZAG homeostasis regulator. The physiological effects of ZAG are related to lipid metabolism, but studies show that ZAG also affects glucose metabolism and is linked to insulin resistance. ZAG has a zinc binding site in its structure, which may indicate that ZAG mediates the effect of zinc on lipid metabolism. The review aimed to verify the available studies on the effects of zinc and ZAG on lipid metabolism. A literature review within the scope of this research area was conducted using articles available in PubMed (including MEDLINE), Web of Science and Cochrane Library databases. An analysis of available studies has shown that zinc improves hepatic lipid metabolism and has an impact on the lipid profile. Numerous studies have found that zinc supplementation in overweight individuals significantly reduced blood levels of total cholesterol, LDL (Low-density lipoprotein)cholesterol and triglycerides, potentially reducing cardiovascular morbidity and mortality. Some results also indicate that it increases HDL-C (High-density lipoprotein) cholesterol levels. ZAG has been shown to play a significant role in reducing obesity and improving insulin sensitivity, both in experimental animal model studies and in human studies. Furthermore, ZAG at physiologically relevant concentrations increases the release of adiponectin from human adipocytes. In addition, ZAG has been shown to inhibit in vitro leptin production. Further studies are needed to provide more data on the role of zinc and zinc-alpha 2-glycoprotein.
C1 [Banaszak, Michalina] Poznan Univ Med Sci, Fac Med Sci, PL-60812 Poznan, Poland.
   [Gorna, Ilona; Przyslawski, Juliusz] Poznan Univ Med Sci, Dept Bromatol, PL-60354 Poznan, Poland.
C3 Poznan University of Medical Sciences; Poznan University of Medical
   Sciences
RP Górna, I (corresponding author), Poznan Univ Med Sci, Dept Bromatol, PL-60354 Poznan, Poland.
EM mi.banaszak97@gmail.com; jprzysla@ump.edu.pl; igorna@ump.edu.pl
RI Górna, Ilona/Y-1707-2019
OI Gorna, Ilona/0000-0002-9652-0785; Banaszak,
   Michalina/0000-0003-2771-0769
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NR 100
TC 55
Z9 55
U1 2
U2 34
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JUN
PY 2021
VL 13
IS 6
AR 2023
DI 10.3390/nu13062023
PG 21
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA SY7ZS
UT WOS:000666101900001
PM 34208404
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Nwadiugwu, MC
AF Nwadiugwu, Martin C.
TI Inflammatory Activities in Type 2 Diabetes Patients With Co-morbid
   Angiopathies and Exploring Beneficial Interventions: A Systematic Review
SO FRONTIERS IN PUBLIC HEALTH
LA English
DT Review
DE diabetic angiopathy; inflammation; commorbidity; intervention study;
   diabetes miletus
ID GLYCATION END-PRODUCTS; ANTIINFLAMMATORY CYTOKINE INTERLEUKIN-10;
   OXIDATIVE STRESS; KAPPA-B; ENDOTHELIAL DYSFUNCTION; PLAQUE INFLAMMATION;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; SOLUBLE RECEPTOR;
   INTERFERON-GAMMA
AB Background: Diabetes is a long-term condition that can be treated and controlled but do not yet have a cure; it could be induced by inflammation and the goal of managing it is to prevent additional co-morbidities and reduce glycemic fluctuations. There is a need to examine inflammatory activities in diabetes-related angiopathies and explore interventions that could reduce the risk for future outcome or ameliorate its effects to provide insights for improved care and management strategies.
   Method: The study was conducted in Embase (1946-2020), Ovid Medline (1950-2020), and PubMed databases (1960-2020) using the PICO framework. Primary studies (randomized controlled trials) on type 2 diabetes mellitus and inflammatory activities in diabetes-related angiopathies were included. Terms for the review were retrieved from the Cochrane library and from PROSPERO using its MeSH thesaurus qualifiers. Nine articles out of 454 total hits met the eligibility criteria. The quality assessment for the selected study was done using the Center for Evidence-Based Medicine Critical Appraisal Sheet.
   Results: Data analysis showed that elevated CRP, TNF-alpha, and IL-6 were the most commonly found inflammatory indicator in diabetes-related angiopathies, while increased IL-10 and soluble RAGE was an indicator for better outcome. Use of drugs such as salsalate, pioglitazone, simvastatin, and fenofibrate but not glimepiride or benfotiamine reported a significant decrease in inflammatory events. Regular exercise and consumption of dietary supplements such as ginger, hesperidin which have anti-inflammatory properties, and those containing prebiotic fibers (e.g., raspberries) revealed a consistent significant (p < 0.05) reduction in inflammatory activities.
   Conclusion: Inflammatory activities are implicated in diabetes-related angiopathies; regular exercise, the intake of healthy dietary supplements, and medications with anti-inflammatory properties could result in improved protective risk outcome for diabetes patients by suppressing inflammatory activities and elevating anti-inflammatory events.
C1 [Nwadiugwu, Martin C.] Univ Stirling, Fac Hlth & Sports, Stirling, Scotland.
C3 University of Stirling
RP Nwadiugwu, MC (corresponding author), Univ Stirling, Fac Hlth & Sports, Stirling, Scotland.
EM martintony4u@gmail.com
RI Nwadiugwu, Martin/AAM-4706-2020
OI Nwadiugwu, Martin/0000-0001-6788-8305
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NR 88
TC 16
Z9 17
U1 0
U2 6
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 2296-2565
J9 FRONT PUBLIC HEALTH
JI Front. Public Health
PD JAN 25
PY 2021
VL 8
AR 600427
DI 10.3389/fpubh.2020.600427
PG 15
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA QD9CH
UT WOS:000615807400001
PM 33569370
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Wang, L
   Cai, Y
   Jian, LG
   Cheung, CW
   Zhang, LQ
   Xia, ZY
AF Wang, Lin
   Cai, Yin
   Jian, Liguo
   Cheung, Chi Wai
   Zhang, Liangqing
   Xia, Zhengyuan
TI Impact of peroxisome proliferator-activated receptor-α on diabetic
   cardiomyopathy
SO CARDIOVASCULAR DIABETOLOGY
LA English
DT Review
DE Diabetic cardiomyopathy; PPAR alpha modulator; Metformin; Glucagon-like
   peptide 1-receptor agonists; Sodium-glucose co-transporter type 2
   inhibitors
ID FATTY-ACID OXIDATION; CHAIN AMINO-ACIDS; CHRONIC HEART-FAILURE;
   COMBINATION LIPID THERAPY; CORONARY-ARTERY-DISEASE; MODULATOR
   SPPARM-ALPHA; PPAR-ALPHA; CARDIOVASCULAR OUTCOMES; DOUBLE-BLIND;
   INSULIN-RESISTANCE
AB The prevalence of cardiomyopathy is higher in diabetic patients than those without diabetes. Diabetic cardiomyopathy (DCM) is defined as a clinical condition of abnormal myocardial structure and performance in diabetic patients without other cardiac risk factors, such as coronary artery disease, hypertension, and significant valvular disease. Multiple molecular events contribute to the development of DCM, which include the alterations in energy metabolism (fatty acid, glucose, ketone and branched chain amino acids) and the abnormalities of subcellular components in the heart, such as impaired insulin signaling, increased oxidative stress, calcium mishandling and inflammation. There are no specific drugs in treating DCM despite of decades of basic and clinical investigations. This is, in part, due to the lack of our understanding as to how heart failure initiates and develops, especially in diabetic patients without an underlying ischemic cause. Some of the traditional anti-diabetic or lipid-lowering agents aimed at shifting the balance of cardiac metabolism from utilizing fat to glucose have been shown inadequately targeting multiple aspects of the conditions. Peroxisome proliferator-activated receptor alpha (PPAR alpha), a transcription factor, plays an important role in mediating DCM-related molecular events. Pharmacological targeting of PPAR alpha activation has been demonstrated to be one of the important strategies for patients with diabetes, metabolic syndrome, and atherosclerotic cardiovascular diseases. The aim of this review is to provide a contemporary view of PPAR alpha in association with the underlying pathophysiological changes in DCM. We discuss the PPAR alpha -related drugs in clinical applications and facts related to the drugs that may be considered as risky (such as fenofibrate, bezafibrate, clofibrate) or safe (pemafibrate, metformin and glucagon-like peptide 1-receptor agonists) or having the potential (sodium-glucose co-transporter 2 inhibitor) in treating DCM.
C1 [Wang, Lin; Cai, Yin; Zhang, Liangqing; Xia, Zhengyuan] Guangdong Med Univ, Dept Anesthesiol, Affiliated Hosp, Zhanjiang, Peoples R China.
   [Wang, Lin; Cai, Yin; Cheung, Chi Wai; Xia, Zhengyuan] Univ Hong Kong, Dept Anaesthesiol, Hong Kong, Peoples R China.
   [Cai, Yin] Hong Kong Polytech Univ, Dept Hlth Technol & Informat, Hong Kong, Peoples R China.
   [Jian, Liguo] Zhengzhou Univ, Affiliated Hosp 2, Dept Cardiol, Zhengzhou, Peoples R China.
C3 Guangdong Medical University; University of Hong Kong; Hong Kong
   Polytechnic University; Zhengzhou University
RP Zhang, LQ; Xia, ZY (corresponding author), Guangdong Med Univ, Dept Anesthesiol, Affiliated Hosp, Zhanjiang, Peoples R China.
EM zhanglq1970@163.com; zyxia@hku.hk
RI Irwin, Michael/C-4286-2009
OI Cai, Yin/0000-0002-7763-0612; Xia, Zhengyuan/0000-0002-7002-5524; Jian,
   Liguo/0009-0003-1557-8796
FU General Research Fund [17123718, 17118619]; Health and Medical Research
   Fund [05161826]; National Natural Science Foundation of China [81870247,
   81800245]
FX The authors' work was supported by the General Research Fund (Nos.
   17123718, 17118619 to Z. Xia), Health and Medical Research Fund (No.
   05161826 to Z. Xia) and in part by The National Natural Science
   Foundation of China (No. 81870247 to Z. Xia, No. 81800245 to Y. Cai).
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NR 192
TC 80
Z9 90
U1 3
U2 21
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1475-2840
J9 CARDIOVASC DIABETOL
JI Cardiovasc. Diabetol.
PD JAN 4
PY 2021
VL 20
IS 1
AR 2
DI 10.1186/s12933-020-01188-0
PG 15
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism
GA PR2HE
UT WOS:000607061600002
PM 33397369
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Chakraborty, S
   Prasad, G
   Marwaha, RK
   Basu, A
   Tandon, N
   Bharadwaj, D
AF Chakraborty, Shraddha
   Prasad, Gauri
   Marwaha, Raman Kumar
   Basu, Analabha
   Tandon, Nikhil
   Bharadwaj, Dwaipayan
TI Comparison of plasma adipocytokines & C-reactive protein levels in
   healthy schoolgoing adolescents from private & government-funded schools
   of Delhi, India
SO INDIAN JOURNAL OF MEDICAL RESEARCH
LA English
DT Article
ID INFLAMMATORY MARKERS; INSULIN-RESISTANCE; OXIDATIVE STRESS; OBESITY;
   ADIPONECTIN; OVERWEIGHT; CHILDREN; LEPTIN; INTERLEUKIN-6; PREVALENCE
AB Background & objectives: Obesity-mediated chronic inflammatory state is primarily governed by lifestyle and food habits in adolescents and marked by alterations in the level of various inflammatory markers. This cross-sectional study was aimed to compare the inflammatory status of healthy Indian adolescents vis-a-vis their obesity profile. The inflammatory state of urban adolescents attending private and government-funded schools, and the relationship between inflammatory marker levels and anthropometric indices in the study participants from both groups were examined. Methods: A total of 4438 study participants (10-17 yr) were chosen from various schools of Delhi, India, and their anthropometric parameters were measured. Plasma adipocytokines (adiponectin, leptin and resistin) of the study participants were measured by enzyme-linked immunosorbent assay, and plasma C-reactive protein (CRP) levels were assayed by a biochemical analyzer. Metabolic syndrome-related risk factors such as waist circumference, hip circumference (HC), fasting glucose, fasting insulin, Homeostatic Model Assessment of Insulin Resistance, total cholesterol, high-density lipoprotein-cholesterol, low-density lipoprotein-cholesterol and triglycerides of normal-weight adolescents were also evaluated. Results: The level of leptin and CRP increased with increasing adiposity, whereas adiponectin levels were found to be negatively related to obesity. All plasma cytokine levels (adiponectin, leptin and resistin) were significantly elevated in female than male adolescents. Age-based classification revealed a distinct trend of variability in the levels of all the inflammatory markers among adolescents of varying age groups. Significant differences were observed between private and government schoolgoing adolescents in terms of anthropometric and inflammatory parameters, with higher adiposity indices in the former group. The relationship of plasma adipokine and CRP levels with various adiposity indices was found to be distinctly different between private and government schoolgoing students. Interpretation & conclusions: Inflammatory markers were significantly elevated in overweight/obese adolescents. The socio-economic condition of urban Indian schoolgoing adolescents reflecting lifestyle transition has profound effects on their adiposity indices and inflammatory states. Longitudinal studies in different regions of the country need to be done to further confirm the findings.
C1 [Chakraborty, Shraddha; Prasad, Gauri] Inst Genom & Integrat Biol, CSIR, Genom & Mol Med Unit, New Delhi, India.
   [Chakraborty, Shraddha; Prasad, Gauri; Bharadwaj, Dwaipayan] Inst Genom & Integrat Biol, CSIR, Acad Sci & Innovat Res, South Campus, New Delhi, India.
   [Marwaha, Raman Kumar] Int Life Sci Inst, Dept Endocrinol, New Delhi, India.
   [Tandon, Nikhil] All India Inst Med Sci, Dept Endocrinol & Metab, New Delhi, India.
   [Bharadwaj, Dwaipayan] Jawaharlal Nehru Univ, Sch Biotechnol, Syst Genom Lab, New Delhi 110067, India.
   [Basu, Analabha] Natl Inst Biomed Genom, Stat & Computat Genom, Kalyani, W Bengal, India.
C3 Council of Scientific & Industrial Research (CSIR) - India; CSIR -
   Institute of Genomics & Integrative Biology (IGIB); Council of
   Scientific & Industrial Research (CSIR) - India; CSIR - Institute of
   Genomics & Integrative Biology (IGIB); Academy of Scientific &
   Innovative Research (AcSIR); All India Institute of Medical Sciences
   (AIIMS) New Delhi; Jawaharlal Nehru University, New Delhi; Department of
   Biotechnology (DBT) India; National Institute of Biomedical Genomics
   (NIBMG)
RP Bharadwaj, D (corresponding author), Jawaharlal Nehru Univ, Sch Biotechnol, Syst Genom Lab, New Delhi 110067, India.
EM db@jnu.ac.in
RI Marwaha, Raman/AAQ-7475-2021
OI Prasad, Gauri/0000-0002-8139-1351; Bharadwaj,
   Dwaipayan/0000-0001-5268-8482; Chakraborty,
   Shraddha/0000-0002-4634-1068; Marwaha, Raman/0000-0002-9698-4280
FU Department of Biotechnology, India, under the projects named 'Childhood
   obesity', inflammatory markers, gene variation and epigenetics' (GLUE)
   [N 1292, GAP 0089]; Department of Science and Technology, Government of
   India [PURSE II CDST/SR/PURSE PHASE II/11]; University Grants
   Commission, Government of India
FX The study was majorly supported by Department of Biotechnology, India,
   under the projects named 'Childhood obesity', inflammatory markers, gene
   variation and epigenetics' (GLUE) (N 1292) and 'Genetics and systems
   biology of childhood obesity in India and Denmark' (BIOCHILD) (GAP
   0089), given to CSIR-Institute of Genomics and Integrative Biology. This
   study was also partially supported by the Department of Science and
   Technology, Government of India (PURSE II CDST/SR/PURSE PHASE II/11),
   given to Jawaharlal Nehru University, New Delhi. The second author (GP)
   acknowledges University Grants Commission, Government of India, for
   providing Senior Research Fellowship.
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NR 30
TC 6
Z9 6
U1 1
U2 1
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, Maharashtra, INDIA
SN 0971-5916
J9 INDIAN J MED RES
JI Indian J. Med. Res.
PD JAN
PY 2020
VL 151
IS 1
BP 47
EP 58
DI 10.4103/ijmr.IJMR_1631_18
PG 12
WC Immunology; Medicine, General & Internal; Medicine, Research &
   Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; General & Internal Medicine; Research & Experimental
   Medicine
GA KT6OZ
UT WOS:000519135000006
PM 32134014
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Gabryelska, A
   Lukasik, ZM
   Makowska, JS
   Bialasiewicz, P
AF Gabryelska, Agata
   Lukasik, Zuzanna M.
   Makowska, Joanna S.
   Bialasiewicz, Piotr
TI Obstructive Sleep Apnea: From Intermittent Hypoxia to Cardiovascular
   Complications via Blood Platelets
SO FRONTIERS IN NEUROLOGY
LA English
DT Review
DE osa; blood platelets; cardiovascular diseases; hypoxia; sleep apnea
ID POSITIVE AIRWAY PRESSURE; LOW-DENSITY-LIPOPROTEIN; C-REACTIVE PROTEIN;
   ENDOTHELIAL DYSFUNCTION; METABOLIC SYNDROME; OXIDATIVE STRESS; THERAPY;
   DISEASE; VOLUME; ACTIVATION
AB Obstructive sleep apnea is a chronic condition characterized by recurrent episodes of apneas or hypopneas during sleep leading to intermittent hypoxemia and arousals. The prevalence of the sleep disordered breathing is estimated that almost 50% of men and 24% of women suffer from moderate to severe form of the disorder. Snoring, collapse of upper airways and intermittent hypoxia are main causes of smoldering systemic inflammation in patients suffering from obstructive sleep apnea. The systematic inflammation is considered one of the key mechanisms leading to significant cardiovascular complications. Blood platelets, formerly not even recognized as cells, are currently gaining attention as crucial players in the immune continuum. Platelet surface is endowed with receptors characteristic for cells classically belonging to the immune system, which enables them to recognize pathogens, immune complexes, and interact in a homo-and heterotypic aggregates. Platelets participate in the process of transcellular production of bioactive lipids by delivering both specific enzymes and substrate molecules. Despite their lack of nucleus, platelets synthetize proteins in a stimuli-dependent manner. Atherosclerosis and consequent cardiovascular complications result from disruption in homeostasis of both of the platelet roles: blood coagulation and inflammatory processes modulation. Platelet parameters, routinely evaluated as a part of complete blood count test, were proposed as markers of cardiovascular comorbidity in patients with obstructive sleep apnea. Platelets were found to be excessively activated in this group of patients, especially in obese subjects. Persistent activation results in enhanced spontaneous aggregability and change in cytokine production. Platelet-lymphocyte ratio was suggested as an independent marker for cardiovascular disease in obstructive sleep apnea syndrome and continuous positive air pressure therapy was found to have an impact on platelet parameters and phenotype. In this literature review we summarize the current knowledge on the subject of platelets involvement in obstructive sleep apnea syndrome and consider the possible pathways in which they contribute to cardiovascular comorbidity.
C1 [Gabryelska, Agata; Bialasiewicz, Piotr] Med Univ Lodz, Dept Sleep Med & Metab Disorders, Lodz, Poland.
   [Lukasik, Zuzanna M.; Makowska, Joanna S.] Med Univ Lodz, Dept Rheumatol, Lodz, Poland.
C3 Medical University Lodz; Medical University Lodz
RP Gabryelska, A (corresponding author), Med Univ Lodz, Dept Sleep Med & Metab Disorders, Lodz, Poland.
EM agata.gabryelska@gmail.com
RI Makowska, Joanna/F-6054-2013; Łukasik, Zuzanna/AAN-1312-2020
OI Lukasik, Zuzanna/0000-0001-9551-3578; Gabryelska,
   Agata/0000-0002-4430-6488; Makowska, Joanna/0000-0003-2036-375X;
   Bialasiewicz, Piotr/0000-0002-8338-1747
FU Medical University of Lodz [564/1-000-00/564-20-021]
FX AG is supported by grant no. 564/1-000-00/564-20-021 from Medical
   University of Lodz.
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NR 122
TC 73
Z9 77
U1 0
U2 15
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2295
J9 FRONT NEUROL
JI Front. Neurol.
PD AUG 3
PY 2018
VL 9
AR 635
DI 10.3389/fneur.2018.00635
PG 10
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA GP3FB
UT WOS:000440726300001
PM 30123179
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Nobili, V
   Mosca, A
   De Vito, R
   Raponi, M
   Scorletti, E
   Byrne, CD
AF Nobili, Valerio
   Mosca, Antonella
   De Vito, Rita
   Raponi, Massimiliano
   Scorletti, Eleonora
   Byrne, Christopher D.
TI Liver zonation in children with non-alcoholic fatty liver disease:
   Associations with dietary fructose and uric acid concentrations
SO LIVER INTERNATIONAL
LA English
DT Article
DE dietary fructose; liver cell plate; liver zonation; lobule;
   non-alcoholic fatty liver disease; non-alcoholic steatohepatitis;
   periportal; perivenous; uric acid
ID METABOLIC SYNDROME; ZONAL DIFFERENCES; KIDNEY-DISEASE; POTENTIAL-ROLE;
   STRESS; NASH; GENERATION; MECHANISM; CELLS
AB Background & AimsAs dietary components are delivered directly to the periportal zone of the liver lobule, there is the potential for greater injury in this zone (zone 1) compared to the perivenous zone (zone 3). We investigated the associations between dietary fructose consumption and uric acid concentrations and differential zonal injury in periportal and perivenous zones.
   MethodsA total of 271 children's histological images were scored in 5 periportal and 5 perivenous zones for steatosis, ballooning, inflammation and fibrosis severity. Dietary fructose consumption (g/d) was assessed and uric acid measured in serum. Logistic regression was undertaken to test associations between both high fructose consumption and hyperuricaemia, and histological disease in periportal and perivenous zones.
   ResultsChildren with a mean age of 12.5years were included in the study. Inflammation (meanSD) was increased in the periportal vs perivenous zones (0.78 +/- 0.43 vs 0.41 +/- 0.48, P=.041). There were non-significant trends towards greater steatosis, ballooning and fibrosis in the periportal zone. In the fully adjusted models, high fructose intake was associated with disease in both zones. Example for periportal and perivenous zones, respectively, steatosis 1.56 (1.12, 2.49) and 1.21 (1.09, 2.73); inflammation 4.29 (2.31, 5.88) and 3.69 (2.14, 4.56); and fibrosis 2.72 (1.43, 3.76) and 1.96 (1.24, 2.37). Hyperuricaemia (uric acid 5.9mg/dL) was associated with inflammation in the periportal zone 1.71 (1.17, 2.35); and was associated with steatosis and fibrosis in both zones; for example, for periportal and perivenous zones, respectively, steatosis 2.98 (1.65, 3.23) and 1.14 (1.05, 1.99); and fibrosis, 2.65 (1.35, 2.99) and 1.31 (1.13, 2.17).
   ConclusionsHigh fructose consumption is associated with disease severity in both lobular zones and hyperuricaemia may be associated with more severe disease in the periportal zone.
C1 [Nobili, Valerio; Mosca, Antonella] Bambino Gesu Pediat Hosp, Hepatometab Unit, Rome, Italy.
   [Nobili, Valerio] Sapienza Univ Rome, Fac Med & Psicol, Dept Pediat, Rome, Italy.
   [De Vito, Rita] Bambino Gesu Pediat Hosp, IRCCS, Histopathol Unit, Rome, Italy.
   [Raponi, Massimiliano] Bambino Gesu Pediat Hosp, IRCCS, Med Directorate, Rome, Italy.
   [Scorletti, Eleonora; Byrne, Christopher D.] Univ Southampton, Fac Med, Human Dev & Hlth Acad Unit, Southampton, Hants, England.
   [Byrne, Christopher D.] Univ Southampton, Univ Hosp Southampton NHS Fdn Trust, NIHR Southampton Biomed Res Ctr, Southampton, Hants, England.
C3 IRCCS Bambino Gesu; Sapienza University Rome; IRCCS Bambino Gesu; IRCCS
   Bambino Gesu; University of Southampton; University of Southampton;
   University Hospital Southampton NHS Foundation Trust
RP Nobili, V (corresponding author), Bambino Gesu Pediat Hosp, IRCCS, Hepatometab Dis Unit, Rome, Italy.
EM valerio.nobili@opbg.net
RI mosca, antonella/JTS-6893-2023; Scorletti, Eleonora/GMX-0079-2022;
   Nobili, Valerio/K-8670-2018
OI Byrne, Christopher D/0000-0001-6322-7753; Mosca,
   Antonella/0000-0001-9646-7462; De Vito, rita/0000-0002-7450-8398
FU Southampton NIHR Biomedical Research Centre
FX ES and CDB are supported in part by the Southampton NIHR Biomedical
   Research Centre.
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NR 35
TC 17
Z9 17
U1 0
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1478-3223
EI 1478-3231
J9 LIVER INT
JI Liver Int.
PD JUN
PY 2018
VL 38
IS 6
BP 1102
EP 1109
DI 10.1111/liv.13661
PG 8
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA GI2UW
UT WOS:000434228400017
PM 29222961
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Wells, GD
   Banks, L
   Caterini, JE
   Thompson, S
   Noseworthy, MD
   Rayner, T
   Syme, C
   McCrindle, BW
   Hamilton, J
AF Wells, Greg D.
   Banks, Laura
   Caterini, Jessica E.
   Thompson, Sara
   Noseworthy, Michael D.
   Rayner, Tammy
   Syme, Catriona
   McCrindle, Brian W.
   Hamilton, Jill
TI The association among skeletal muscle phosphocreatine recovery,
   adiposity, and insulin resistance in children
SO PEDIATRIC OBESITY
LA English
DT Article
DE childhood obesity; P-31-magnetic resonance spectroscopy; phosphocreatine
   recovery; insulin resistance; exercise
ID MITOCHONDRIAL-FUNCTION; METABOLIC SYNDROME; OBESE ADOLESCENTS;
   CYSTIC-FIBROSIS; EXERCISE; SENSITIVITY; FAT; DYSFUNCTION; GLUCOSE;
   WEIGHT
AB BackgroundObesity is associated with cardiometabolic disturbances, which may have significant implications for musculoskeletal health and exercise tolerance.
   ObjectiveWe sought to determine the association between muscle structure, function, and metabolism in adolescents across the weight spectrum.
   MethodsThis cross-sectional case-control study included overweight and obese participants (n=24) 8-18 years of age with a body mass index (BMI)85th percentile for age and gender, and non-obese participants (n=24) with a BMI<85(th) percentile. Body composition, physical activity, peak aerobic capacity, cardiometabolic blood markers and insulin resistance (measured by the homeostatic model assessment of insulin resistance, HOMA-IR), skeletal muscle mitochondrial oxidative capacity (via (31)Phosphorous-Magnetic Resonance Spectroscopy, P-31-MRS, to assess phosphocreatine (PCr) recovery after exercise), and extramyocellular and intramyocellular lipid (IMCL) levels (via (1)Hydrogen-MRS) were assessed. Stepwise regression was performed to examine the factors associated with oxidative capacity.
   Resultsbese and overweight patients had similar age, height, and physical activity to non-obese controls, but obese and overweight participants exhibited higher insulin resistance. Obese and overweight participants had longer PCr recovery than non-obese controls following 5x30s of moderate-intensity exercise (51.220.1s vs. 23.9 +/- 7.5s, p=0.004). In univariate correlation analysis, impaired PCr recovery was associated with a higher BMI z-score (r(s)=0.51, p<0.001), circulating triglycerides (r(s)=0.41, p=0.005), and HOMA-IR (r(s)=0.46, p=0.001). In stepwise multivariate regression analysis, impaired PCr recovery was associated with a higher BMI z-score (=0.47, p=0.002), but not insulin resistance (=0.07, p=0.07) or circulating triglycerides (=0.16 p=0.33).
   ConclusionA slower phosphocreatine recovery following aerobic exercise is strongly associated with increasing adiposity. A slower metabolic recovery following aerobic exercise stress suggests that endurance exercise training in obese adolescents may be an optimal strategy to target exercise intolerance in this cohort.
C1 [Wells, Greg D.; Banks, Laura; Caterini, Jessica E.; Thompson, Sara; Hamilton, Jill] Hosp Sick Children, Physiol & Expt Med, 555 Univ Ave, Toronto, ON M5G 1X8, Canada.
   [Wells, Greg D.; Banks, Laura; Caterini, Jessica E.; Thompson, Sara] Fac Kinesiol & Phys Educ, 100 Devonshire Pl, Toronto, ON M5S 2C9, Canada.
   [Noseworthy, Michael D.] McMaster Univ, Sch Biomed Engn, 1280 Main St W, Hamilton, ON, Canada.
   [Noseworthy, Michael D.] McMaster Univ, Dept Elect & Comp Engn, 1280 Main St W, Hamilton, ON, Canada.
   [Rayner, Tammy] Hosp Sick Children, Dept Diagnost Imaging, 555 Univ Ave, Toronto, ON M5G 1X8, Canada.
   [Syme, Catriona; Hamilton, Jill] Hosp Sick Children, Div Endocrinol, 555 Univ Ave, Toronto, ON M5G 1X8, Canada.
   [McCrindle, Brian W.] Hosp Sick Children, Div Cardiol, 555 Univ Ave, Toronto, ON M5G 1X8, Canada.
   [McCrindle, Brian W.; Hamilton, Jill] Univ Toronto, Dept Pediat, Toronto, ON M5S 1A8, Canada.
C3 University of Toronto; Hospital for Sick Children (SickKids); McMaster
   University; McMaster University; University of Toronto; Hospital for
   Sick Children (SickKids); University of Toronto; Hospital for Sick
   Children (SickKids); University of Toronto; Hospital for Sick Children
   (SickKids); University of Toronto
RP Wells, GD (corresponding author), Univ Toronto, Fac Kinesiol & Phys Educ, 100 Devonshire Pl, Toronto, ON M5S 2C9, Canada.
EM greg.wells@utoronto.ca
RI Caterini, Jessica/B-7905-2016; Noseworthy, Michael/B-2957-2011
OI Caterini, Jessica/0000-0002-4065-0775; Wells, Greg/0000-0001-5197-5041;
   Noseworthy, Michael/0000-0003-1464-159X
FU Canadian Institute of Health Research
FX This work was supported by a Canadian Institute of Health Research team
   grant in childhood obesity (HISTORY: High Impact Strategies Towards
   Overweight Reduction in Youth).
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NR 27
TC 8
Z9 9
U1 0
U2 17
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2047-6310
EI 2047-6302
J9 PEDIATR OBES
JI Pediatr. Obes.
PD APR
PY 2017
VL 12
IS 2
BP 163
EP 170
DI 10.1111/ijpo.12123
PG 8
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA EM7KP
UT WOS:000395490200011
PM 26916682
DA 2025-06-11
ER

PT J
AU Koksal, AR
   Boga, S
   Alkim, H
   Sen, I
   Neijmann, ST
   Alkim, C
AF Koksal, Ali R.
   Boga, Salih
   Alkim, Huseyin
   Sen, Ilker
   Neijmann, Sebnem T.
   Alkim, Canan
TI Chemerin: a new biomarker to predict postendoscopic retrograde
   cholangiopancreatography pancreatitis
SO EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
LA English
DT Article
ID POST-ERCP PANCREATITIS; NECROSIS-FACTOR-ALPHA; INSULIN-RESISTANCE;
   RISK-FACTORS; METABOLIC SYNDROME; OXIDATIVE STRESS; FAT DISTRIBUTION;
   PIVOTAL ROLE; ASSOCIATION; INFLAMMATION
AB Introduction Individuals with increased visceral adiposity are considered to be more sensitive and more prone to severe acute pancreatitis because of the inflammatory microenvironment they have. We hypothesized that insulin resistance, adipokines, and proinflammatory cytokines that markedly affect the course of pancreatitis can contribute toward development of postendoscopic retrograde cholangiopancreatography (post-ERCP) pancreatitis (PEP) and aimed to investigate the association between PEP risk and preprocedural serum vaspin, chemerin, tumor necrosis factor a, interleukin-6 (IL-6) levels, and homeostasis model assessment of insulin resistance.
   Patients and methods Eighty-two patients with a diagnosis of choledocholithiasis and 30 controls were enrolled. Preprocedural chemerin, vaspin, IL-6, and well-known PEP risk factors were compared between PEP and non-PEP groups.
   Results The mean age of the patients was 56.3 +/- 14.4 years; 52 patients were women. Adipocytokine levels, BMIs, and waist circumferences of the patient group were found to be higher than those of the controls. Total cannulation success and the mean procedure time were 82.9% and 28.7 +/- 8.8 min, respectively. PEP developed in 12 (14.6%) patients. Chemerin levels in the PEP group were higher than those in the non-PEP group (580.2 +/- 172.5 vs. 392.2 +/- 168.2 ng/ml, P<0.01). Insulin resistance was higher in the PEP group than the non-PEP group (P = 0.001), but there was no significant difference between PEP and non-PEP groups in terms of preprocedural vaspin, tumor necrosis factor a, IL-6, and C-reactive protein levels. According to logistic regression analysis, increased chemerin levels, homeostasis model assessment of insulin resistance 2.5 or greater, and pancreatic duct cannulation were found to be independent risk factors for PEP [odds ratio (OR)= 1.006, P= 0.006; OR= 4.57, P= 0.05; OR= 6.54, P= 0.02].
   Conclusion Elevated serum chemerin levels and insulin resistance are independent risk factors of PEP development. Copyright (C) 2016 Wolters Kluwer Health, Inc. All rights reserved.
C1 [Koksal, Ali R.; Boga, Salih; Alkim, Huseyin; Sen, Ilker; Alkim, Canan] Sisli Hamidiye Etfal Educ & Res Hosp, Dept Gastroenterol, Halaskargazi Av Etfal St, TR-34371 Istanbul, Turkey.
   [Neijmann, Sebnem T.] Bakirkoy Dr Sadi Konuk Educ & Res Hosp, Dept Biochem, Istanbul, Turkey.
C3 Istanbul Sisli Hamidiye Etfal Training & Research Hospital; Bakirkoy Dr.
   Sadi Konuk Research & Training Hospital
RP Koksal, AR (corresponding author), Sisli Hamidiye Etfal Educ & Res Hosp, Dept Gastroenterol, Halaskargazi Av Etfal St, TR-34371 Istanbul, Turkey.
EM arkoksal@gmail.com
RI Alkim, Huseyin/IZD-8869-2023; Şen, İlker/AFQ-5754-2022; Koksal,
   Ali/AAG-1478-2019
OI Koksal, Ali Riza/0000-0002-5693-5951; sen, ilker/0000-0001-6230-5457;
   Alkim, Huseyin/0000-0001-7875-0627; Alkim, Canan/0000-0002-6388-518X
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NR 53
TC 4
Z9 4
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0954-691X
EI 1473-5687
J9 EUR J GASTROEN HEPAT
JI Eur. J. Gastroenterol. Hepatol.
PD JUN
PY 2016
VL 28
IS 6
BP 714
EP 721
DI 10.1097/MEG.0000000000000597
PG 8
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA DK7ZX
UT WOS:000375147100017
PM 26854798
DA 2025-06-11
ER

PT J
AU Nichols, TC
   Merricks, EP
   Bellinger, DA
   Raymer, RA
   Yu, J
   Lam, D
   Koch, GG
   Busby, WH
   Clemmons, DR
AF Nichols, Timothy C.
   Merricks, Elizabeth P.
   Bellinger, Dwight A.
   Raymer, Robin A.
   Yu, Jing
   Lam, Diana
   Koch, Gary G.
   Busby, Walker H., Jr.
   Clemmons, David R.
TI Oxidized LDL and Fructosamine Associated with Severity of Coronary
   Artery Atherosclerosis in Insulin Resistant Pigs Fed a High Fat/High
   NaCl Diet
SO PLOS ONE
LA English
DT Article
ID LOW-DENSITY-LIPOPROTEIN; TYPE-2 DIABETES-MELLITUS; IMPAIRED
   GLUCOSE-TOLERANCE; ADIPOSE-TISSUE CELLULARITY; LOW-GRADE INFLAMMATION;
   VON-WILLEBRAND-FACTOR; METABOLIC-SYNDROME; OXIDATIVE STRESS; ACCELERATED
   ATHEROSCLEROSIS; CARDIOVASCULAR-DISEASE
AB Background
   Insulin-resistant subjects develop more severe and diffuse coronary artery atherosclerosis than insulin-sensitive controls but the mechanisms that mediate this atherosclerosis phenotype are unknown.
   Research Objective
   To determine the metabolic parameters that associate with the severity of coronary atherosclerosis in insulin resistant pigs fed a high fat/high NaCl diet.
   Key Methods
   The primary endpoint was severity of coronary atherosclerosis in adult pigs (Sus scrofa, n = 37) fed a high fat diet that also contained high NaCl (56% above recommended levels) for 1 year.
   Principal Findings
   Twenty pigs developed severe and diffuse distal coronary artery atherosclerosis (i.e., severe = intimal area as a percent medial area > 200% in at least 2 coronary artery cross sections and diffuse distal = intimal area as a percent medial area >= 150% over 3 sections separated by 2 cm in the distal half of the coronary artery). The other 17 pigs had substantially less coronary artery atherosclerosis. All 37 pigs had blood pressure in a range that would be considered hypertensive in humans and developed elevations in total and LDL and HDL cholesterol, weight gain, increased backfat, and increased insulin resistance (Bergman Si) without overt diabetes. Insulin resistance was not associated with atherosclerosis severity. Five additional pigs fed regular pig chow also developed increased insulin resistance but essentially no change in the other variables and little to no detectible coronary atherosclerosis. Most importantly, the 20 high fat/high NaCl diet -fed pigs with severe and diffuse distal coronary artery atherosclerosis had substantially greater increases (p<0.05) in oxidized LDL (oxLDL) and fructosamine consistent with increased protein glycation.
   Conclusion
   In pigs fed a high fat/high NaCl diet, glycated proteins are induced in the absence of overt diabetes and this degree of increase is associated with the development of severe and diffuse distal coronary artery atherosclerosis.
C1 [Nichols, Timothy C.; Merricks, Elizabeth P.; Bellinger, Dwight A.; Raymer, Robin A.] Univ N Carolina, Dept Pathol & Lab Med, Chapel Hill, NC 27599 USA.
   [Nichols, Timothy C.; Busby, Walker H., Jr.; Clemmons, David R.] Univ N Carolina, Dept Med, Chapel Hill, NC USA.
   [Yu, Jing; Lam, Diana; Koch, Gary G.] Univ N Carolina, Dept Biostat, Chapel Hill, NC USA.
C3 University of North Carolina; University of North Carolina Chapel Hill;
   University of North Carolina; University of North Carolina Chapel Hill;
   University of North Carolina; University of North Carolina Chapel Hill
RP Nichols, TC (corresponding author), Univ N Carolina, Dept Pathol & Lab Med, Chapel Hill, NC 27599 USA.
EM tnichols@med.unc.edu
FU National Heart, Lung, and Blood institute of the National Institutes of
   Health [HL069364]; North Carolina Biotechnology Center (NCBC) [MRG1101]
FX This work was supported by the National Heart, Lung, and Blood institute
   of the National Institutes of Health (HL069364, DRC, TCN) and the North
   Carolina Biotechnology Center (NCBC MRG1101, TCN and DRC). The funders
   had no role in study design, data collection and analysis, decision to
   publish, or preparation of the manuscript.
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NR 117
TC 7
Z9 7
U1 0
U2 5
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JUL 6
PY 2015
VL 10
IS 7
AR e0132302
DI 10.1371/journal.pone.0132302
PG 26
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA CN1DQ
UT WOS:000358157600235
PM 26147990
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Salehi-Abargouei, A
   Maghsoudi, Z
   Shirani, F
   Azadbakht, L
AF Salehi-Abargouei, Amin
   Maghsoudi, Zahra
   Shirani, Fatemeh
   Azadbakht, Leila
TI Effects of Dietary Approaches to Stop Hypertension (DASH)-style diet on
   fatal or nonfatal cardiovascular diseases-Incidence: A systematic review
   and meta-analysis on observational prospective studies
SO NUTRITION
LA English
DT Review
DE DASH diet; Cardiovascular diseases; Coronary heart disease; Stroke;
   Heart failure; Cohort studies
ID TYPE-2 DIABETIC-PATIENTS; CORONARY-HEART-DISEASE; BLOOD-PRESSURE CHANGE;
   OXIDATIVE STRESS; DASH DIET; EATING PLAN; WEIGHT-LOSS; VEGETABLE
   CONSUMPTION; RISK-FACTORS; PATTERNS
AB Background: Cardiovascular diseases (CVDs) are a group of disorders affecting heart and blood vessels. However, protective roles are proposed for Dietary Approaches to Stop Hypertension (DASH)-style diets.
   Objective: The aim of this review was to summarize and if possible quantify the longitudinal effects of a DASH-style diet on the incidence of CVDs.
   Design: Pubmed, ISI web of science, and EMBASE were searched and cohort studies that examined the DASH-style diet in relation to CVDs, coronary heart disease (CHD), stroke, and heart failure (HF) were selected. Cohort studies which included participants with specific CVD risk factors like diabetes mellitus, metabolic syndrome, obesity or hypertension were excluded from review. Relative risks (RRs) that were reported for fully adjusted models and their confidence intervals were extracted for meta-analysis.
   Results: Regarding the adherence to the DASH diet and the incidence of CVDs, stroke, CHD, and HF, only 6 studies met our criteria to be included in this systematic review. Meta-analysis showed that imitating a DASH-like diet can significantly reduce CVDs (RR = 0.80; 95% confidence interval [CI], 0.74-0.86; P < 0.001), CHD (RR = 0.79; 95% CI, 0.71-0.88; P < 0.001), stroke (RR = 0.81, 95% CI, 0.72-0.92; P < 0.001), and HF (RR = 0.71, 95% CI, 0.58-0.88; P < 0.001) risk. A linear and negative association was obtained between DASH-style diet concordance and all CVDs, as well.
   Conclusion: In conclusion, our results showed that a DASH-like diet can significantly protect against CVDs, CHD, stroke, and HF risk by 20%, 21%, 19% and 29%, respectively. Furthermore, there is a significant reverse linear association between DASH diet consumption and CVDs, CHD, stroke, and HF risk. (C) 2013 Elsevier Inc. All rights reserved.
C1 [Salehi-Abargouei, Amin; Maghsoudi, Zahra; Shirani, Fatemeh; Azadbakht, Leila] Isfahan Univ Med Sci, Food Secur Res Ctr, Esfahan, Iran.
   [Salehi-Abargouei, Amin; Maghsoudi, Zahra; Shirani, Fatemeh; Azadbakht, Leila] Isfahan Univ Med Sci, Sch Nutr & Food Sci, Dept Community Nutr, Esfahan, Iran.
   [Salehi-Abargouei, Amin; Maghsoudi, Zahra; Shirani, Fatemeh] Isfahan Univ Med Sci, Students Res Comm, Esfahan, Iran.
C3 Isfahan University of Medical Sciences; Isfahan University of Medical
   Sciences; Isfahan University of Medical Sciences
RP Azadbakht, L (corresponding author), Isfahan Univ Med Sci, Food Secur Res Ctr, Esfahan, Iran.
EM azadbakht@hlth.mui.ac.ir
RI Shirani, Fatemeh/D-7442-2016; Shirani, Fatemeh/O-8882-2018;
   Salehi-Abargouei, Amin/C-9039-2011; Azadbakht, Leila/N-2801-2018
OI Shirani, Fatemeh/0000-0003-2802-1033; Shirani, Dr
   Fatemeh/0000-0001-5223-2530; Salehi-Abargouei, Amin/0000-0002-7580-6717;
   Azadbakht, Leila/0000-0002-5955-6818
FU Food Security Research Center, Isfahan University of Medical Sciences,
   Isfahan, Iran
FX This paper is funded by Food Security Research Center, Isfahan
   University of Medical Sciences, Isfahan, Iran.
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NR 49
TC 250
Z9 288
U1 3
U2 116
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0899-9007
EI 1873-1244
J9 NUTRITION
JI Nutrition
PD APR
PY 2013
VL 29
IS 4
BP 611
EP 618
DI 10.1016/j.nut.2012.12.018
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 114YQ
UT WOS:000316779300004
PM 23466047
DA 2025-06-11
ER

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AU Duran, M
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   Gunebakmaz, Ozgur
   Uysal, Onur Kadir
   Celik, Ahmet
   Yarlioglues, Mikail
   Karakaya, Ekrem
   Oguzhan, Abdurrahman
   Eryol, Namik Kemal
   Kaya, Mehmet Gungor
TI Increased gamma-glutamyl transferase level is associated with absence of
   coronary collateral vessels in patients with acute coronary syndrome: an
   observational study
SO ANATOLIAN JOURNAL OF CARDIOLOGY
LA English
DT Article
DE Gamma-glutamyl transferase; coronary collateral vessel; acute coronary
   syndrome; regression analysis; sensitivity; specificity
ID CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; OXIDATIVE STRESS; ARTERY
   OCCLUSION; BLOOD-FLOW; RISK; MECHANISMS; MORTALITY; HEART;
   ATHEROSCLEROSIS
AB Objective: Elevated serum gamma-glutamyl transferase (GGT) level has been proposed as a risk factor for coronary artery disease and is associated with poor clinical outcome in acute coronary syndrome (ACS). We aimed to evaluate the relationship between GGT level and presence of coronary collateral vessels (CCV) patients with ACS.
   Methods: We evaluated 178 patients with ACS in this cross-sectional-observational study. Traditional laboratory and clinical parameters and serum GGT levels were measured. All patients underwent coronary angiography on the first day after admission and patients who had >80% stenosis of coronary artery were included in the study. The CCVs graded according to the Rentrop scoring system and Rentrop 0, 1, 2 and 3 were determined in respectively 76 (42.7%), 32 (18.0%), 33 (18.5%), and 37 (20.8%) patients. Rentrop grade 0 was accepted as no CCV development (Group 1), Rentrop grades 1-2-3 were accepted as presence of CCV development (Group 2). Statistical analysis was performed using independent-samples t, Mann-Whitney U and Chi-squared tests, logistic regression and receiver operator curve analyses.
   Results: Mean age was 62+/-10 years and 134 (75.3%) of patients were male. Group 1 consisted of 76 (42.7%) patients and Group 2 consisted of 102 (57.3%) patients. The median and minimum-maximum values of serum GGT were 33.5 (8-128) U/L for Group 1 and 23 (2-83) U/L for Group 2. Absence of CCV was significantly associated with high levels of GGT (p<0.001), alanine-aminotransferase (p=0.001), glucose (p=0.011) and low levels of total protein (p=0.020). At multivariate analysis, high levels of GGT were independent predictors of absence of CCV (OR=0.953, 95% CI 0.912-0.996, p=0.031).
   Conclusion: High levels of GGT on admission were associated with absence of CCV in patients with ACS. (Anadolu Kardiyol Derg 2012; 12: 652-8)
C1 [Gunebakmaz, Ozgur; Karakaya, Ekrem] Dunya Hosp, Clin Cardiol, Kayseri, Turkey.
   [Celik, Ahmet] Elazig Educ & Res Hosp, Clin Cardiol, Elazig, Turkey.
   [Yarlioglues, Mikail] Ankara Educ & Res Hosp, Clin Cardiol, Ankara, Turkey.
   [Oguzhan, Abdurrahman; Eryol, Namik Kemal; Kaya, Mehmet Gungor] Erciyes Univ, Fac Med, Dept Cardiol, Kayseri, Turkey.
   [Duran, Mustafa; Uysal, Onur Kadir] Kayseri Educ & Res Hosp, Clin Cardiol, Kayseri, Turkey.
C3 Dunya Medical Center; Elazig Training & Research Hospital; Ankara
   Training & Research Hospital; Erciyes University; Kayseri Training &
   Research Hospital
RP Duran, M (corresponding author), Kayseri Egitim & Arastirma Hastanesi, Kardiyol Klin, Kayseri, Turkey.
EM mduran2@gmail.com
RI Yarlioglues, Mikail/IZD-4680-2023; Duran, Mustafa/ABT-9168-2022; Celik,
   Ahmet/AAA-6615-2021
OI Celik, Ahmet/0000-0002-9417-7610; Yarlioglues,
   Mikail/0000-0001-8905-9807
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NR 41
TC 5
Z9 5
U1 0
U2 4
PU TURKISH SOC CARDIOLOGY
PI BAHCELIEVLER
PA COBANCESME SANAYI CAD NO 11, NISH ISTANBUL A BLOK KAT 8 NO 47-48,
   YENIBOSNA, BAHCELIEVLER, ISTANBUL 34196, TURKEY
SN 2149-2263
EI 2149-2271
J9 ANATOL J CARDIOL
JI Anat. J. Cardiol.
PD DEC
PY 2012
VL 12
IS 8
BP 652
EP 658
DI 10.5152/akd.2012.217
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 059YP
UT WOS:000312741900014
PM 22968300
DA 2025-06-11
ER

PT J
AU Teixeira, TFS
   Collado, MC
   Ferreira, CLLF
   Bressan, J
   Peluzio, MDG
AF Teixeira, Tatiana F. S.
   Carmen Collado, Maria
   Ferreira, Celia L. L. F.
   Bressan, Josefina
   Peluzio, Maria do Carmo G.
TI Potential mechanisms for the emerging link between obesity and increased
   intestinal permeability
SO NUTRITION RESEARCH
LA English
DT Review
DE Obesity; Microbiota; Endotoxins; Insulin resistance; Intestinal
   permeability; Nutritional deficiencies
ID INFLAMMATORY BOWEL DISEASES; GUT MICROBIOTA COMPOSITION; DIET-INDUCED
   OBESITY; INSULIN-RESISTANCE; VITAMIN-D; BACTERIAL OVERGROWTH; METABOLIC
   SYNDROME; HEPATIC STEATOSIS; BARRIER FUNCTION; NONALCOHOLIC
   STEATOHEPATITIS
AB Recently, increased attention has been paid to the link between gut microbial composition and obesity. Gut microbiota is a source of endotoxins whose increase in plasma is related to obesity and insulin resistance through increased intestinal permeability in animal models; however, this relationship still needs to be confirmed in humans. That intestinal permeability is subject to change and that it might be the interface between gut microbiota and endotoxins in the core of metabolic dysfunctions reinforce the need to understand the mechanisms involved in these aspects to direct more efficient therapeutic approaches. Therefore, in this review, we focus on the emerging link between obesity and increased intestinal permeability, including the possible factors that contribute to increased intestinal permeability in obese subjects. We address the concept of intestinal permeability, how it is measured, and the intestinal segments that may be affected. We then describe 3 factors that may have an influence on intestinal permeability in obesity: microbial dysbiosis, dietary pattern (high-fructose and high-fat diet), and nutritional deficiencies. Gaps in the current knowledge of the role of Toll-like receptors ligands to induce insulin resistance, the routes for lipopolysaccharide circulation, and the impact of altered intestinal microbiota in obesity, as well as the limitations of current permeability tests and other potential useful markers, are discussed. More studies are needed to reveal how changes occur in the microbiota. The factors such as changes in the dietary pattern and the improvement of nutritional deficiencies appear to influence intestinal permeability, and impact metabolism must be examined. Also, additional studies are necessary to better understand how probiotic supplements, prebiotics, and micronutrients can improve stress-induced gastrointestinal barrier dysfunction and the influence these factors have on host defense. Hence, the topics presented in this review may be beneficial in directing future studies that assess gut barrier function in obesity. (C) 2012 Elsevier Inc. All rights reserved.
C1 [Teixeira, Tatiana F. S.; Bressan, Josefina; Peluzio, Maria do Carmo G.] Univ Fed Vicosa, Dept Nutr & Saude, BR-36570000 Vicosa, MG, Brazil.
   [Carmen Collado, Maria] Consejo Super Invest Cient IATA CSIC, Inst Agroquim & Tecnol Alimentos, Valencia 46980, Spain.
   [Ferreira, Celia L. L. F.] Univ Fed Vicosa, Dept Food Technol, BR-36570000 Vicosa, MG, Brazil.
C3 Universidade Federal de Vicosa; Consejo Superior de Investigaciones
   Cientificas (CSIC); Instituto de Agroquimica y Tecnologia de los
   Alimentos (IATA); Universidade Federal de Vicosa
RP Peluzio, MDG (corresponding author), Univ Fed Vicosa, Dept Nutr & Saude, Ave PH Rolfs S-N, BR-36570000 Vicosa, MG, Brazil.
EM mpeluzio@ufv.br
RI Bressan, Josefina/A-2598-2009; COLLADO, MARIA CARMEN/H-4924-2012
OI COLLADO, MARIA CARMEN/0000-0002-6204-4864; PELUZIO, MARIA DO CARMO
   GOUVEIA/0000-0003-4665-7043; Bressan, Josefina/0000-0002-4993-9436
FU Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (Capes);
   Fundacao de Amparo a Pesquisa do Estado de Minas Gerais (FAPEMIG)
   [001/2010]
FX We would like to thank Coordenacao de Aperfeicoamento de Pessoal de
   Nivel Superior (Capes) for the scholarship granted to T.F.S.T. and
   Fundacao de Amparo a Pesquisa do Estado de Minas Gerais (FAPEMIG) for
   funding the project related to intestinal permeability and obesity
   registered at Universidade Federal de Vicosa under the protocol number
   001/2010.
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NR 104
TC 185
Z9 208
U1 1
U2 77
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0271-5317
J9 NUTR RES
JI Nutr. Res.
PD SEP
PY 2012
VL 32
IS 9
BP 637
EP 647
DI 10.1016/j.nutres.2012.07.003
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 029LB
UT WOS:000310496000001
PM 23084636
DA 2025-06-11
ER

PT J
AU Patel, PJ
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   Wilensky, RL
   Rader, DJ
AF Patel, Parin J.
   Khera, Amit V.
   Jafri, Kashif
   Wilensky, Robert L.
   Rader, Daniel J.
TI The Anti-Oxidative Capacity of High-Density Lipoprotein Is Reduced in
   Acute Coronary Syndrome But Not in Stable Coronary Artery Disease
SO JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
LA English
DT Article
DE acute coronary syndrome(s); coronary artery disease; HDL function; HDL
   inflammatory index; oxidized LDL
ID FRACTIONAL ESTERIFICATION RATE; HEART-DISEASE; MYOCARDIAL-INFARCTION;
   OXIDATIVE STRESS; HDL-CHOLESTEROL; ENDOTHELIAL FUNCTION; METABOLIC
   SYNDROME; ATHEROGENIC INDEX; DEPLETED PLASMA; PARTICLE-SIZE
AB Objectives This study examined an anti-inflammatory property of high-density lipoprotein (HDL) in subjects with acute coronary syndrome (ACS) and stable coronary artery disease (CAD) compared with control subjects.
   Background HDL has anti-inflammatory properties in vitro, but its relationship to coronary disease in humans is unclear. The high-density lipoprotein inflammatory index (HII) measures the ability of HDL to mitigate oxidation of low-density lipoprotein; this function may be impaired in ACS and/or CAD.
   Methods We measured HII in 193 patients undergoing angiography for symptoms of CAD. Control subjects (n = 99) had no angiographic CAD, chronic CAD subjects (n = 51) had >= 70% vessel stenosis, and ACS subjects (n = 43) had >= 20% vessel stenosis and ischemia or infarction. We also examined HII in a cohort of healthy subjects randomly assigned to a statin or placebo.
   Results Subjects who had ACS had higher HII (less antioxidative capacity) compared with controls (1.57 vs. 1.17, p = 0.005) or those with chronic CAD (1.57 vs. 1.11, p = 0.006). HII was not different in subjects with stable CAD compared with controls. Furthermore, those subjects with higher HII were more likely to have ACS than no CAD (quartile 4 vs. 1, odds ratio [OR]: 1.74, p = 0.008). In a multivariate logistic regression model, HII was associated with ACS after adjusting for traditional cardiac risk factors (OR: 3.8, p = 0.003). There was a small improvement in HII after statin therapy compared with placebo (-14%, p = 0.03).
   Conclusions HDL has less anti-inflammatory capacity as assessed by HII in the setting of ACS compared with controls or subjects with chronic CAD. (J Am Coll Cardiol 2011;58:2068-75) (C) 2011 by the American College of Cardiology Foundation
C1 [Patel, Parin J.; Khera, Amit V.; Jafri, Kashif; Rader, Daniel J.] Univ Penn, Sch Med, Philadelphia, PA 19104 USA.
   [Patel, Parin J.; Wilensky, Robert L.; Rader, Daniel J.] Hosp Univ Penn, Dept Med, Div Cardiovasc Med, Philadelphia, PA 19104 USA.
   [Khera, Amit V.; Wilensky, Robert L.; Rader, Daniel J.] Cardiovasc Inst, Philadelphia, PA USA.
   [Khera, Amit V.; Rader, Daniel J.] Inst Translat Med & Therapeut, Philadelphia, PA USA.
C3 University of Pennsylvania; University of Pennsylvania
RP Patel, PJ (corresponding author), Univ Penn, Sch Med, 654 BRB 2-3,421 Curie Blvd, Philadelphia, PA 19104 USA.
EM parin.patel@post.harvard.edu; rader@mail.med.upenn.edu
RI Khera, Amit/ADI-2450-2022; Rader, Daniel/AFQ-9696-2022
FU National Heart, Lung, and Blood Institute [HL22633, P50 HL70128]; Doris
   Duke Charitable Foundation; Howard Hughes Medical Institute
FX This work was supported by grants from the National Heart, Lung, and
   Blood Institute (HL22633 and P50 HL70128) and a Distinguished Clinical
   Scientist Award from the Doris Duke Charitable Foundation. Dr. Khera was
   supported by a medical student research fellowship from the Howard
   Hughes Medical Institute. Dr. Wilensky has equity interest in Johnson &
   Johnson, Inc. All other authors have reported that they have no
   relationships relevant to the contents of this paper to disclose.
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NR 46
TC 103
Z9 115
U1 0
U2 9
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0735-1097
EI 1558-3597
J9 J AM COLL CARDIOL
JI J. Am. Coll. Cardiol.
PD NOV 8
PY 2011
VL 58
IS 20
BP 2068
EP 2075
DI 10.1016/j.jacc.2011.08.030
PG 8
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 842MN
UT WOS:000296603700003
PM 22051328
OA Bronze
DA 2025-06-11
ER

PT J
AU Schooling, CM
   Jiang, CQ
   Lam, TH
   Zhang, WS
   Cheng, KK
   Leung, GM
AF Schooling, C. Mary
   Jiang, ChaoQiang
   Lam, Tai Hing
   Zhang, WeiSen
   Cheng, Kar Keung
   Leung, Gabriel M.
TI Parental Death during Childhood and Adult Cardiovascular Risk in a
   Developing Country: The Guangzhou Biobank Cohort Study
SO PLOS ONE
LA English
DT Article
ID CORONARY-HEART-DISEASE; EARLY-LIFE STRESS; BLOOD-CELL COUNT; METABOLIC
   SYNDROME; TRUNK LENGTH; EXPERIENCES; PUBERTY; OBESITY; HEALTH;
   CIRCUMSTANCES
AB Background: In observational studies from western countries childhood emotional adversity is usually associated with adult cardiovascular disease. These findings are open to contextual biases making evidence from other settings valuable. We examined the association of a potential marker of childhood emotional adversity with cardiovascular disease risk factors in a developing country.
   Methods: We used multivariable regression in cross-sectional analysis of older (>= 50 years) men (n = 7,885) and women (n = 20,886) from the Guangzhou Biobank Cohort Study (2003-8) to examine the adjusted association of early life (<18 years) parental death (none, one or two deaths) with blood pressure, fasting glucose, LDL-cholesterol, HDL-cholesterol, triglycerides, body mass index (BMI), waist-hip ratio (WHR) and white blood cell count (WBC). We used seated height and delayed 10-word recall to assess content validity of parental death as a measure of childhood emotional adversity. We also examined whether associations varied by sex.
   Results: Early life parental death was associated with shorter age-and sex-adjusted seated height. It was also associated with lower 10-word recall score adjusted for age, sex, socio-economic position, leg length and lifestyle. Similarly, adjusted early life parental death was not associated with blood pressure, fasting glucose, LDL-cholesterol or HDL-cholesterol but was associated with lower BMI (-0.40, 95% confidence interval (CI) -0.62 to -0.19 for 2 compared with no early life parental deaths) and triglycerides. Associations varied by sex for WHR and WBC. Among men only, early life parental death was associated with lower WHR (-0.008, 95% CI -0.015 to -0.001) and WBC (-0.35 10(9)/L, 95% CI -0.56 to -0.13).
   Conclusions: In a non-western population from a developing country, childhood emotional adversity was negatively associated with some cardiovascular risk factors, particularly among men. Our study suggests that some of the observed associations in western populations may be socially rather than biologically based or may be population specific.
C1 [Schooling, C. Mary; Lam, Tai Hing; Leung, Gabriel M.] Univ Hong Kong, Sch Publ Hlth, Dept Community Med, Hong Kong, Hong Kong, Peoples R China.
   [Jiang, ChaoQiang; Zhang, WeiSen] Guangzhou 12 Hosp, Guangzhou Occupat Dis Prevent & Treatment Ctr, Guangzhou, Guangdong, Peoples R China.
   [Cheng, Kar Keung] Univ Birmingham, Dept Publ Hlth & Epidemiol, Birmingham, W Midlands, England.
   [Schooling, C. Mary] CUNY, Sch Publ Hlth, New York, NY 10021 USA.
C3 University of Hong Kong; University of Birmingham; City University of
   New York (CUNY) System
RP Schooling, CM (corresponding author), Univ Hong Kong, Sch Publ Hlth, Dept Community Med, Hong Kong, Hong Kong, Peoples R China.
EM cms1@hkucc.hku.hk
RI Leung, Gabriel/C-4336-2009; Schooling, Catherine/C-4386-2009; Jelakovic,
   Bojan/J-2058-2017; Cheng, KK/AAL-8899-2021; Lam, Tai Hing/C-4317-2009
OI Cheng, KK/0000-0002-1516-1857; Lam, Tai Hing/0000-0002-2033-9971;
   Schooling, Mary/0000-0001-9933-5887; Leung, Gabriel/0000-0002-2503-6283
FU University of Hong Kong Foundation for Development and Research;
   University of Hong Kong University Research Committee Strategic Research
   Theme Public Health, Hong Kong; Guangzhou Public Health Bureau;
   Guangzhou Science and Technology Bureau, Guangzhou, China; University of
   Birmingham, UK
FX The study was funded by The University of Hong Kong Foundation for
   Development and Research, and the University of Hong Kong University
   Research Committee Strategic Research Theme Public Health, Hong Kong;
   Guangzhou Public Health Bureau, and Guangzhou Science and Technology
   Bureau, Guangzhou, China, and The University of Birmingham, UK. The
   funders had no role in study design, data collection and analysis,
   decision to publish or preparation of the manuscript.
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NR 51
TC 17
Z9 18
U1 0
U2 6
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAY 16
PY 2011
VL 6
IS 5
AR e19675
DI 10.1371/journal.pone.0019675
PG 8
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Science & Technology - Other Topics
GA 764TP
UT WOS:000290656300017
PM 21603607
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Pitsavos, C
   Skoumas, I
   Masoura, C
   Aznaouridis, K
   Papadimitriou, L
   Chrysohoou, C
   Giotsas, N
   Toutouza, M
   Stefanadis, C
AF Pitsavos, Christos
   Skoumas, Ioannis
   Masoura, Constantina
   Aznaouridis, Konstantinos
   Papadimitriou, Lambros
   Chrysohoou, Christina
   Giotsas, Nikolaos
   Toutouza, Marina
   Stefanadis, Christodoulos
TI Prevalence and determinants of coronary artery disease in males and
   females with familial combined hyperlipidaemia
SO ATHEROSCLEROSIS
LA English
DT Article
DE familial combined hyperlipidaemia; coronary artery disease; gender risk
   factors
ID CARDIOVASCULAR RISK-FACTORS; HEART-DISEASE; INSULIN-RESISTANCE;
   METABOLIC SYNDROME; ISCHEMIC-STROKE; LIPOPROTEIN; ASSOCIATION; COMMON;
   WOMEN; MEN
AB Background; Familial combined hyperlipidaemia (FCH) is all inlicrited dyslipidaernia that is related to a high risk of coronary artery disease (CAD). We evaluated the prevalence of CAD in a large FCH population and the association of risk factors with CAD accordino to gender.
   Methods: In this single-center, observational study, lipid and lipoprotein variables were measure in untreated patients with FCH (565 males and 302 females). CAD was defined as a documented history of myocardial infarction or coronary revascularization, or all abnormal coronary angiogram (stenosis of >50% in in epicardial coronary artery), or angina plus abnormal imaging stress test.
   Results: Males had higher triglyceride level (P < 0.001) but lower total cholesterol (P < 0.001) and HDL-cholesterol level (P< 0.001) compared to women. The prevalence of CAD was 22.2% in men and 4.6% in women (P<0.001). In logistic regression analysis, male gender was associated with a higher risk of CAD independent of lipid parameters and other risk factors (adjusted ORs for CAD 9.4. P<0.001). In gender-specific analysis. age (OR= 1.06 per 1-year increase, P<0.001), diabetes (OR=2.42, P<0.01) and Lp(a) (OR=1.09 per 1-mg/dL increase, P<0.01) were independent predictors of CAD in men. In women, age (OR=1.24 P<0.01), total cholesterol (OR=1.022 per 1-mg/dl increase, P<0.05) and fasting glucose (OR=1.031 per 1-mg/dL increase, P<0.05) were independently associated with CAD.
   Conclusions; In FCH patients, the prevalence of CAD is higher in males than in females, independent of lipidaemic profile and other risk factors. Among lipid variables, Lp(a) and cholesterol level are predictors of CAD in males and females respectively. (C) 2007 Elsevier Ireland Ltd. All rights reserved.
C1 [Pitsavos, Christos; Skoumas, Ioannis; Masoura, Constantina; Aznaouridis, Konstantinos; Papadimitriou, Lambros; Chrysohoou, Christina; Giotsas, Nikolaos; Toutouza, Marina; Stefanadis, Christodoulos] Hippokrateion Hosp, Dept Cardiol 1, Athens Med Sch, Athens, Greece.
C3 Hippokration General Hospital; National & Kapodistrian University of
   Athens
RP Masoura, C (corresponding author), Agiou Thoma 48, Athens 19002, Greece.
EM kmasoura@gmail.com
RI Stefanadis, Christodoulos/ABH-2232-2020; papadimitriou,
   lampros/I-3316-2013
OI Stefanadis, Christodoulos/0000-0001-5974-6454; papadimitriou,
   lampros/0000-0003-3356-0963; Chrysohoou, Christina/0000-0002-6340-3996
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NR 33
TC 17
Z9 19
U1 0
U2 6
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0021-9150
EI 1879-1484
J9 ATHEROSCLEROSIS
JI Atherosclerosis
PD AUG
PY 2008
VL 199
IS 2
BP 402
EP 407
DI 10.1016/j.atherosclerosis.2007.11.021
PG 6
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 342LQ
UT WOS:000258786000024
PM 18164018
DA 2025-06-11
ER

PT J
AU Wei, YM
   Guo, JQ
AF Wei, Yimin
   Guo, Jianqiang
TI High Triglyceride-Glucose Index Is Associated with Poor Prognosis in
   Patients with Acute Pancreatitis
SO DIGESTIVE DISEASES AND SCIENCES
LA English
DT Article
DE TyG index; Insulin resistance; Acute pancreatitis; Prognosis; Biomarker
ID NEUTROPHIL-LYMPHOCYTE RATIO; METABOLIC SYNDROME; ATLANTA CLASSIFICATION;
   INTERNATIONAL COHORT; INSULIN-RESISTANCE; OXIDATIVE STRESS;
   HYPERTRIGLYCERIDEMIA; SEVERITY; OUTCOMES; INDICATOR
AB Background Acute pancreatitis (AP) is a common gastrointestinal disease worldwide. Severe acute pancreatitis (SAP) is characterized as persistent organ failure with a mortality rate as high as 20-30%. Early assessment of the severity and screening out possible SAP is of great significance. Given that there is still a lack of both convenient and practical tools for evaluating SAP, we conducted this study to explore the association between TyG index and acute pancreatitis prognosis. Methods A total of 353 in-patients diagnosed with acute pancreatitis in the Second Hospital of Shandong University were retrospectively enrolled from January 2018 to November 2021 in this study. According to the Atlanta Classification, they were divided into two groups based on the AP severity. Demographic information and clinical materials were retrospectively collected. The TyG index calculation formula is as follows: ln [fasting triglycerides (mg/dL) x fasting plasma glucose (mg/dL)/2]. Statistical analyses were performed using SPSS software (IBM version 22.0) and Medcalc software. Multivariable logistic regression analyses were used to investigate independent predictors for SAP. ROC curve was plotted to assess the predictive ability and cutoffs of TyG index. Results A total of 353 AP patients were respectively enrolled in this study, of which 47 suffered from SAP. Compared with the non-SAP group, TyG index was significantly higher in the SAP group (10.44 +/- 1.55 vs 9.33 +/- 1.44, P < 0.001). Multivariate logistic regression analysis showed that TyG index was an independent risk factor for SAP (OR 1.835, 95% CI 1.380-2.442 P < 0.001), with a cutoff of 8.76 for non-HTG/AAP and 11.81 for HTG/AAP by ROC curve. TyG index of patients who suffered from SIRS, OF, APFC, and ANC was higher than those without (P < 0.05). Conclusions The triglyceride-glucose index is an independent risk factor for SAP. High TyG index is closely related to SAP and AP-related complications.
C1 [Wei, Yimin] Shandong Univ, Cheeloo Coll Med, Jinan 250012, Peoples R China.
   [Guo, Jianqiang] Shandong Univ, Second Hosp, Dept Gastroenterol, Cheeloo Coll Med, Jinan 250033, Peoples R China.
C3 Shandong University; Shandong University
RP Guo, JQ (corresponding author), Shandong Univ, Second Hosp, Dept Gastroenterol, Cheeloo Coll Med, Jinan 250033, Peoples R China.
EM anymanwei@163.com; jianqiangg@sdu.edu.cn
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NR 54
TC 8
Z9 10
U1 2
U2 16
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0163-2116
EI 1573-2568
J9 DIGEST DIS SCI
JI Dig. Dis. Sci.
PD MAR
PY 2023
VL 68
IS 3
BP 978
EP 987
DI 10.1007/s10620-022-07567-9
EA JUN 2022
PG 10
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 9X8FJ
UT WOS:000814473000002
PM 35731427
DA 2025-06-11
ER

PT J
AU Shaikh, SU
   Yasmeen, G
AF Shaikh, Saif Ullah
   Yasmeen, Ghazala
TI β Natriuretic Peptide evaluation as prognostic biomarker in chronic
   kidney disease associated cardiovascular complications
SO BIOSCIENCE RESEARCH
LA English
DT Article
DE CVD; CKD; BNP; GFR; Cardiac risk ratio
ID METABOLIC SYNDROME; DYSFUNCTION
AB Background: B-type natriuretic peptides (BNP) were initially discovered in the porcrine brain, but the highest levels were reported in heart. It is a peptide with 32 aminoacids and is synthesized from the left ventricle as a result of increased myocardial wall stress. There is sufficient data in support of its cardiac damage contribution in the cardio vascular disease (CVD) but does it work in the development of chronic kidney disease (CKD) associated CVD is yet unclear that is why we planned to investigate its relation with the primary cardiac insult in CKD patients by executing a case control study. A case control study was carried out on 140 male and female subjects with chronic kidney disease especially secondary to hypertensive and diabetic nephropathy. Demographics and case history of patients were noted on a performa and categorize patients in to groups according to base line levels of Glomerular filteration rate (GFR) as defined by the classification of the national kidney foundation. The BNP levels of these patients and controls were recorded and correlate to lipid profile for the assessment of cardiac risk ratio in these patients Out of 210 subjects, 70 served as controls while 140 were CKD patients. The results showed mean ranks of TC levels in cases, 158.2mg%, where as in controls it was 131.6mg% with significance of p -value <0.025, Similarly for lipid profile the difference in case -control values found statistically significant as LDL(p<0.05), HDL (p<0.0001), TG (p<0.05), while the deterioration in renal function measured through blood urea (p<0.0001), and creatinine (p<0.0001) found also significant in CKD patient. BNP levels in CKD population were measured significantly higher (p<0.005) as matched with those of controls. This study is helpful in identifying the risk population at the right time to initiate the preventive measures. The findings showed a set BNP value to start prophylactic therapy thus would delay the cardiac disease onset and its complications.
C1 [Shaikh, Saif Ullah] Bahria Univ Med & Dent Coll, Dept Physiol, Karachi, Pakistan.
   [Yasmeen, Ghazala] Univ Karachi, Dept Physiol, Karachi, Pakistan.
C3 University of Karachi
RP Yasmeen, G (corresponding author), Univ Karachi, Dept Physiol, Karachi, Pakistan.
EM ghazmeen@uok.edu.pk
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NR 28
TC 0
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PU INNOVATIVE SCIENTIFIC INFORMATION & SERVICES NETWORK
PI FAISALABAD
PA INNOVATIVE SCIENTIFIC INFORMATION & SERVICES NETWORK, FAISALABAD, 00000,
   PAKISTAN
SN 1811-9506
EI 2218-3973
J9 BIOSCI RES
JI Biosci. Res.
PD JAN-MAR
PY 2022
VL 19
IS 1
BP 198
EP 203
PG 6
WC Biology
WE Emerging Sources Citation Index (ESCI)
SC Life Sciences & Biomedicine - Other Topics
GA YZ0UX
UT WOS:000755199800022
DA 2025-06-11
ER

PT J
AU Lee, HS
   Park, BS
   Kang, HM
   Kim, JH
   Shin, SH
   Kim, IR
AF Lee, Hye-Sung
   Park, Bong-Soo
   Kang, Hae-Mi
   Kim, Jung-Han
   Shin, Sang-Hun
   Kim, In-Ryoung
TI Role of Luteolin-Induced Apoptosis and Autophagy in Human Glioblastoma
   Cell Lines
SO MEDICINA-LITHUANIA
LA English
DT Article
DE luteolin; globlastoma; apoptosis; autophagy
ID CANCER; PATHWAYS; DEATH; LC3; RESISTANCE; STRESS; FLOW
AB Background and Objectives: Malignant glioblastoma (GBM) is caused by abnormal proliferation of glial cells, which are found in the brain. The therapeutic effects of surgical treatment, radiation therapy, and chemo-therapy against GBM are relatively poor compared with their effects against other tumors. Luteolin is abundant in peanut shells and is also found in herbs and other plants, such as thyme, green pepper, and celery. Luteolin is known to be effective against obesity and metabolic syndrome. The anti-inflammatory, and anti-cancer activities of luteolin have been investigated. Most studies have focused on the antioxidant and anti-inflammatory effects of luteolin, which is a natural flavonoid. However, the association between the induction of apoptosis by luteolin in GBM and autophagy has not yet been investigated. This study thus aimed to confirm the occurrence of luteolin-induced apoptosis and autophagy in GBM cells and to assess their relationship. Materials and Methods: A172 and U-373MG glioblastoma cell lines were used for this experiment. We confirmed the apoptosis effect of Luteolin on GBM cells using methods such as 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, immunofluorescence, Flow cytometry (FACS) western blot, and real-time quantitative PCR (qPCR). Results: In the luteolin-treated A172 and U-373MG cells, cell viability decreased in a concentration- and time-dependent manner. In addition, in A172 and U-373MG cells treated with luteolin at concentrations greater than 100 mu M, nuclear fragmentation, which is a typical morphological change characterizing apoptosis, as well as fragmentation of caspase-3 and Poly (ADP-ribose) polymerase (PARP), which are apoptosis-related factors, were observed. Autophagy was induced after treatment with at least 50 mu M luteolin. Inhibition of autophagy using 3MA allowed for a low concentration of luteolin to more effectively induce apoptosis in A172 and U-373MG cells. Conclusions: Results showed that luteolin induces apoptosis and autophagy and that the luteolin-induced autophagy promotes cell survival. Therefore, an appropriate combination therapy involving luteolin and an autophagy inhibitor is expected to improve the prognosis of GBM treatment.
C1 [Lee, Hye-Sung; Shin, Sang-Hun] Pusan Natl Univ, Sch Dent, Dept Oral & Maxillofacial Surg, Yangsan Si 50612, South Korea.
   [Park, Bong-Soo; Kang, Hae-Mi; Kim, In-Ryoung] Pusan Natl Univ, Sch Dent, Dept Oral Anat, Busandaehak Ro 49, Mulguem Eup 50612, Yangsan Si, South Korea.
   [Park, Bong-Soo; Kim, In-Ryoung] Pusan Natl Univ, Dent & Life Sci Inst, Sch Dent, Yangsan Si 50612, South Korea.
   [Kim, Jung-Han] Dong A Univ, Dept Oral & Maxillofacial Surg, Med Ctr, 26 Daesingongwon Ro, Busan 49201, South Korea.
C3 Pusan National University; Pusan National University; Pusan National
   University; Dong A University
RP Kim, IR (corresponding author), Pusan Natl Univ, Sch Dent, Dept Oral Anat, Busandaehak Ro 49, Mulguem Eup 50612, Yangsan Si, South Korea.; Kim, IR (corresponding author), Pusan Natl Univ, Dent & Life Sci Inst, Sch Dent, Yangsan Si 50612, South Korea.
EM sofun28@naver.com; parkbs@pusan.ac.kr; khaemi90@naver.com;
   omfsjhkim@dau.ac.kr; ssh8080@pusan.ac.kr; biowool@pusan.ac.kr
RI Lee, Hye-Sung/M-9755-2019; kim, Inryoung/AGF-2385-2022
OI kim, Inryoung/0000-0003-0232-0385
FU National Research Foundation of Korea (NRF) - Korea government
   [NRF-2018R1D1A1B07047739, NRF-2019R1A2C108405712]
FX This research was funded by the National Research Foundation of Korea
   (NRF) grant funded by the Korea government (No. NRF-2018R1D1A1B07047739
   and NRF-2019R1A2C108405712).
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NR 58
TC 31
Z9 31
U1 4
U2 21
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1010-660X
EI 1648-9144
J9 MEDICINA-LITHUANIA
JI Med. Lith.
PD SEP
PY 2021
VL 57
IS 9
AR 879
DI 10.3390/medicina57090879
PG 14
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA UV7FK
UT WOS:000699639100001
PM 34577802
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Dallak, M
AF Dallak, Mohammad
TI Unacylated ghrelin stimulates steroidogenesis in lean rats and reverses
   reproductive dysfunction in high fat diet-fed rats
SO SYSTEMS BIOLOGY IN REPRODUCTIVE MEDICINE
LA English
DT Article
DE Ghrelin; HFD; obese; sperm; steroidogenesis; rats
ID HORMONE-BINDING GLOBULIN; BODY-MASS INDEX; INSULIN SENSITIVITY; ACYLATED
   GHRELIN; NONACYLATED GHRELIN; MALE-INFERTILITY; TESTICULAR FUNCTION;
   METABOLIC SYNDROME; LEPTIN RECEPTOR; MALE-FERTILITY
AB This study investigated the effect of sub-chronic administration of unacylated ghrelin (UAG) on steroidogenesis, sperm parameter, and reproductive function in lean and high fat diet (HFD)-induced obese male rats. Rats were divided into 4 groups (n = 12 each) as 1) Control-fed standard diets (STD): (10 kcal%), 2) STD + UAG (200 ng/kg, i.p.), 3) HFD obese: fed HFD (45 kcal%), and 4) HFD + UAG. Diet regimen was continued for 16 weeks after which normal saline as a vehicle or UAG was administered to desired groups for the next 4 weeks. In vitro, testicular slices were incubated with increasing concentrations of UAG (10(-8)-10(-6) M) in the presence or absence of GSH-R1a antagonist, [D-Lys-3]-GHRP-6 (10(-6) M). UAG significantly increased the circulatory levels of FSH, LH and testosterone, increased testicular testosterone levels and sperm count and motility in lean and obese rats and reduced sperm morphological abnormalities and increased pregnancy rate and number of pups at birth in HFD-obese rats. Associated with the reduction in the final body and fat masses weights and independent of food intake, UAG post-therapy to both lean and HFD-fed rats significantly lowered fasting blood glucose and insulin levels, lowered HOMA-IR value, enhanced OGTT and ITT, lowered circulatory leptin levels, downregulated aromatase expression in adipose and testicular tissue and inhibited HFD-induced testicular oxidative stress and activation of cleaved caspase-3. Dysregulation of testicular levels of StAR, SF-1, CYP11A1 in the testis of both groups as well as in the in vitro preparation, in a dose-dependent manner, independent of GSH-R1a and not associated with activation of STAT3, a mediator of leptin signaling was apparent. In conclusion, administration of UAG can enhance reproductive function in lean rats and reverses HFD-induced reproductive dysfunction in obese rats.
C1 [Dallak, Mohammad] King Khalid Univ, Dept Physiol, Coll Med, Abha, Saudi Arabia.
C3 King Khalid University
RP Dallak, M (corresponding author), King Khalid Univ, Dept Physiol, Coll Med, Abha, Saudi Arabia.
EM mdallak@yahoo.com
RI Dallak, Mohammad/GQP-7852-2022
OI Dallak, Mohammad/0000-0003-2524-4426
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NR 72
TC 10
Z9 10
U1 1
U2 8
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1939-6368
EI 1939-6376
J9 SYST BIOL REPROD MED
JI Syst. Biol. Reprod. Med.
PD MAR 4
PY 2019
VL 65
IS 2
BP 129
EP 146
DI 10.1080/19396368.2018.1523971
PG 18
WC Andrology; Reproductive Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Reproductive Biology
GA HQ0OO
UT WOS:000462094900003
PM 30265152
DA 2025-06-11
ER

PT J
AU Rizzo, M
   Cappello, F
   Marfil, R
   Nibali, L
   Gammazza, AM
   Rappa, F
   Bonaventura, G
   Galindo-Moreno, P
   O'Valle, F
   Zummo, G
   de Macario, EC
   Macario, AJL
   Mesa, F
AF Rizzo, Manfredi
   Cappello, Francesco
   Marfil, Rafael
   Nibali, Luigi
   Gammazza, Antonella Marino
   Rappa, Francesca
   Bonaventura, Giuseppe
   Galindo-Moreno, Pablo
   O'Valle, Francisco
   Zummo, Giovanni
   de Macario, Everly Conway
   Macario, Alberto J. L.
   Mesa, Francisco
TI Heat-shock protein 60 kDa and atherogenic dyslipidemia in patients with
   untreated mild periodontitis: a pilot study
SO CELL STRESS & CHAPERONES
LA English
DT Article
DE Periodontitis; Hsp60; Small, dense LDL; Risk factors; Cardiovascular
   disease
ID HEAT-SHOCK-PROTEIN; DENSITY LIPOPROTEIN-CHOLESTEROL;
   PORPHYROMONAS-GINGIVALIS; ENZYMATIC DETERMINATION;
   CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; RISK-FACTORS;
   ATHEROSCLEROSIS; HSP60; STRESS
AB Identification of predictors of cardiovascular risk can help in the prevention of pathologic episodes and the management of patients at all stages of illness. Here, we investigated the relationships between serum levels of Hsp60 and dyslipidemia in patients with periodontitis by performing a cross-sectional study of 22 patients with mild periodontitis without any prior treatment for it (i.e., drug na < ve) and 22 healthy controls, matched for age and body mass index (BMI). All subjects were evaluated for periodontal status, gingival inflammation, and oral hygiene. Levels of circulating Hsp60, C-reactive protein (CRP), and plasma lipids were measured, and small, dense low-density lipoproteins (LDL) were indirectly assessed by determining the triglycerides/high-density lipoproteins (HDL) cholesterol ratio. We also assessed by immunohistochemistry Hsp60 levels in oral mucosa of patients and controls. No difference was found in CRP levels or plasma lipids between the two groups, but subjects with periodontitis showed, in comparison to controls, higher levels of small, dense LDL (p = 0.0355) and circulating Hsp60 concentrations (p < 0.0001). However, levels of mucosal Hsp60 did not change significantly between groups. Correlation analysis revealed that circulating Hsp60 inversely correlated with HDL-cholesterol (r = -0.589, p = 0.0039), and positively with triglycerides (r = +0.877, p < 0.0001), and small, dense LDL (r = +0.925, p < 0.0001). Serum Hsp60 significantly correlated with the degree of periodontal disease (r = +0.403, p = 0.0434). In brief, untreated patients with mild periodontitis had increased small, dense LDL and serum Hsp60 concentrations, in comparison to age- and BMI-matched controls and both parameters showed a strong positive correlation. Our data indicate that atherogenic dyslipidemia and elevated circulating Hsp60 tend to be linked and associated to periodontal pathology. Thus, the road is open to investigate the potential value of elevated levels of circulating Hsp60 as predictor of risk for cardiovascular disease when associated to dyslipidemia in periodontitis patients.
C1 [Rizzo, Manfredi; Cappello, Francesco; Gammazza, Antonella Marino; Rappa, Francesca; Macario, Alberto J. L.] Ist Euromediterraneo Sci & Tecnol, Palermo, Italy.
   [Cappello, Francesco; Gammazza, Antonella Marino; Rappa, Francesca; Bonaventura, Giuseppe; Zummo, Giovanni] Univ Palermo, Dept Expt Biomed & Clin Neurosci, Palermo, Italy.
   [Rizzo, Manfredi] Univ Palermo, Dept Internal Med & Med Specialties, I-90127 Palermo, Italy.
   [Marfil, Rafael; Galindo-Moreno, Pablo; O'Valle, Francisco; Mesa, Francisco] Univ Granada, Dept Periodontol, Granada, Spain.
   [Marfil, Rafael; Galindo-Moreno, Pablo; O'Valle, Francisco; Mesa, Francisco] Univ Granada, Dept Oral Surg & Pathol, Granada, Spain.
   [Nibali, Luigi] UCL, UCL Eastman Inst, Dept Periodontol, London, England.
   [de Macario, Everly Conway; Macario, Alberto J. L.] Univ Maryland, Sch Med, Dept Microbiol & Immunol, Baltimore, MD 21201 USA.
   [de Macario, Everly Conway; Macario, Alberto J. L.] IMET, Baltimore, MD USA.
C3 University of Palermo; University of Palermo; University of Granada;
   University of Granada; University of London; University College London;
   University System of Maryland; University of Maryland Baltimore
RP Rizzo, M (corresponding author), Ist Euromediterraneo Sci & Tecnol, Palermo, Italy.
EM mrizzo@unipa.it
RI O¨Valle, Francisco/AAA-9151-2019; Francesca, Rappa/ADW-8431-2022; RIZZO,
   MANFREDI/GZL-0551-2022; Gammazza, Antonella/AAV-3123-2020; Mesa,
   Francisco/L-9712-2018; Galindo-Moreno, Pablo/F-5567-2015; Cappello,
   Francesco/F-9153-2012
OI Mesa, Francisco/0000-0002-8293-2527; Marino Gammazza,
   Antonella/0000-0002-1683-3803; rappa, francesca/0000-0001-6610-5268;
   Galindo-Moreno, Pablo/0000-0002-6614-6470; RIZZO,
   Manfredi/0000-0002-9549-8504; Cappello, Francesco/0000-0001-9288-1148
FU University of Palermo; IEMEST (Istituto Euro-Mediterraneo di Scienza e
   Tecnologia)
FX This work has been supported by University of Palermo (funds MR and FC)
   and IEMEST (Istituto Euro-Mediterraneo di Scienza e Tecnologia; funds FC
   and AJLM).
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NR 56
TC 47
Z9 48
U1 0
U2 6
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1355-8145
J9 CELL STRESS CHAPERON
JI Cell Stress Chaperones
PD MAY
PY 2012
VL 17
IS 3
BP 399
EP 407
DI 10.1007/s12192-011-0315-1
PG 9
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA 918CP
UT WOS:000302227200011
PM 22215516
OA Green Published, Green Submitted, hybrid
DA 2025-06-11
ER

PT J
AU Elmarakby, AA
AF Elmarakby, Ahmed A.
TI Reno-protective mechanisms of epoxyeicosatrienoic acids in
   cardiovascular disease
SO AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE
   PHYSIOLOGY
LA English
DT Review
DE diabetes; hypertension; renal injury; hemeoxygenase; inflammation;
   oxidative stress
ID SOLUBLE EPOXIDE HYDROLASE; ACTIVATED-RECEPTOR-ALPHA; SPONTANEOUSLY
   HYPERTENSIVE-RATS; SALT-SENSITIVE HYPERTENSION; ISCHEMIA-REPERFUSION
   INJURY; EPOXYGENASE-DERIVED EICOSANOIDS; ENDOTHELIAL-CELL PROLIFERATION;
   BLOOD-PRESSURE REGULATION; ARTERIAL SMOOTH-MUSCLE;
   11,12-EPOXYEICOSATRIENOIC ACID
AB Elmarakby AA. Reno-protective mechanisms of epoxyeicosatrienoic acids in cardiovascular disease. Am J Physiol Regul Integr Comp Physiol 302: R321-R330, 2012. First published November 23, 2011; doi:10.1152/ajpregu.00606.2011.-Cardiovascular disease (CVD) is the leading cause of mortality worldwide, and it is well known that end-stage renal disease (ESRD) is a profound consequence of the progression of CVD. Present treatments only slow CVD progression to ESRD, and it is imperative that new therapeutic strategies are developed to prevent the incidence of ESRD. Because epoxyeicosatrienoic acids (EETs) have been shown to elicit reno-protective effects in hypertensive animal models, the current review will focus on addressing the reno-protective mechanisms of EETs in CVD. The cytochrome P-450 epoxygenase catalyzes the oxidation of arachidonic acid to EETs. EETs have been identified as endothelium-derived hyperpolarizing factors (EDHFs) with vasodilatory, anti-inflammatory, antihypertensive, and antiplatelet aggregation properties. EETs also have profound effects on vascular migration and proliferation and promote angiogenesis. The progression of CVD has been linked to decreased EETs levels, leading to the concept that EETs should be therapeutically targeted to prevent end-organ damage associated with CVD. However, EETs are quickly degraded by the enzyme soluble epoxide hydrolase (sEH) to their less active diols, dihydroxyeicosatrienoic acids (DHETs). As such, one way to increase EETs level is to inhibit their degradation to DHETs by using sEH inhibitors. Inhibition of sEH has been shown to effectively reduce blood pressure and organ damage in experimental models of CVD. Another approach to target EETs is to develop EET analogs with improved solubility and resistance to auto-oxidation and metabolism by sEH. For example, stable ether EET analogs dilate afferent arterioles and lower blood pressure in hypertensive rodent animal models. EET agonists also improve insulin signaling and vascular function in animal models of metabolic syndrome.
C1 Georgia Hlth Sci Univ, Div Pharmacol, Dept Oral Biol, Augusta, GA 30912 USA.
C3 University System of Georgia; Augusta University
RP Elmarakby, AA (corresponding author), Georgia Hlth Sci Univ, Div Pharmacol, Dept Oral Biol, Augusta, GA 30912 USA.
EM aelmarakby@georgiahealth.edu
RI Elmarakby, Ahmed/ABF-5055-2021
FU Georgia Health Sciences University; Pilot Study Research Program;
   American Heart Association
FX This work was supported by grants from Georgia Health Sciences
   University start-up fund and Pilot Study Research Program and the
   American Heart Association Scientist Development Grant (to A.A.
   Elmarakby).
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NR 131
TC 42
Z9 45
U1 0
U2 3
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0363-6119
EI 1522-1490
J9 AM J PHYSIOL-REG I
JI Am. J. Physiol.-Regul. Integr. Comp. Physiol.
PD FEB
PY 2012
VL 302
IS 3
BP R321
EP R330
DI 10.1152/ajpregu.00606.2011
PG 10
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA 896ZB
UT WOS:000300609000002
PM 22116511
DA 2025-06-11
ER

PT J
AU do Carmo, JM
   da Silva, AA
   Cai, ZW
   Lin, SY
   Dubinion, JH
   Hall, JE
AF do Carmo, Jussara M.
   da Silva, Alexandre A.
   Cai, Zhengwei
   Lin, Shuying
   Dubinion, John H.
   Hall, John E.
TI Control of Blood Pressure, Appetite, and Glucose by Leptin in Mice
   Lacking Leptin Receptors in Proopiomelanocortin Neurons
SO HYPERTENSION
LA English
DT Article
DE food intake; glucose; heart rate; acute stress; baroreceptor
   sensitivity; obesity; melanocortins
ID CARDIOVASCULAR ACTIONS; NERVOUS-SYSTEM; DEFICIENT MICE; OBESITY;
   CLONING; GENE; IDENTIFICATION; MUTATION; CNS
AB Although the central nervous system melanocortin system is an important regulator of energy balance, the role of proopiomelanocortin (POMC) neurons in mediating the chronic effects of leptin on appetite, blood pressure, and glucose regulation is unknown. Using Cre/loxP technology we tested whether leptin receptor deletion in POMC neurons (LepR(flox/flox)/POMC-Cre mice) attenuates the chronic effects of leptin to increase mean arterial pressure (MAP), enhance glucose use and oxygen consumption, and reduce appetite. LepR(flox/flox)/POMC-Cre, wild-type, LepR(flox/flox), and POMC-Cre mice were instrumented for MAP and heart rate measurement by telemetry and venous catheters for infusions. LepR(flox/flox)/POMC-Cre mice were heavier, hyperglycemic, hyperinsulinemic, and hyperleptinemic compared with wild-type, LepR(flox/flox), and POMC-Cre mice. Despite exhibiting features of metabolic syndrome, LepR(flox/flox)/ POMC-Cre mice had normal MAP and heart rate compared with LepR(flox/flox) but lower MAP and heart rate compared with wild-type mice. After a 5-day control period, leptin was infused (2 mu g/kg per minute, IV) for 7 days. In control mice, leptin increased MAP by approximate to 5 mm Hg despite decreasing food intake by approximate to 35%. In contrast, leptin infusion in LepR(flox/flox)/POMC-Cre mice reduced MAP by approximate to 3 mm Hg and food intake by approximate to 28%. Leptin significantly decreased insulin and glucose levels in control mice but not in LepR(flox/flox)/POMC-Cre mice. Leptin increased oxygen consumption in LepR(flox/flox)/POMC-Cre and wild-type mice. Activation of POMC neurons is necessary for the chronic effects of leptin to raise MAP and reduce insulin and glucose levels, whereas leptin receptors in other areas of the brain other than POMC neurons appear to play a key role in mediating the chronic effects of leptin on appetite and oxygen consumption. (Hypertension. 2011;57:918-926.) . Online Data Supplement
C1 [do Carmo, Jussara M.; da Silva, Alexandre A.; Dubinion, John H.; Hall, John E.] Univ Mississippi, Med Ctr, Dept Physiol, Jackson, MS 39216 USA.
   [do Carmo, Jussara M.; da Silva, Alexandre A.; Dubinion, John H.; Hall, John E.] Univ Mississippi, Med Ctr, Dept Biophys, Jackson, MS 39216 USA.
   [Cai, Zhengwei; Lin, Shuying] Univ Mississippi, Med Ctr, Dept Pediat, Jackson, MS 39216 USA.
C3 University of Mississippi Medical Center; University of Mississippi;
   University of Mississippi; University of Mississippi Medical Center;
   University of Mississippi; University of Mississippi Medical Center
RP do Carmo, JM (corresponding author), Univ Mississippi, Med Ctr, Dept Physiol & Biophys, 2500 N State St, Jackson, MS 39216 USA.
EM jdocarmo@umc.edu
RI da Silva, Alexandre/A-6947-2009; Silva, Alexandre/K-8054-2014
OI da Silva, Alexandre/0000-0002-3233-7674; Silva,
   Alexandre/0000-0003-4504-0607; Hall, John/0000-0001-9867-5855
FU National Heart, Lung, and Blood Institute [PO1HL-51971]; American Heart
   Association
FX This research was supported by the National Heart, Lung, and Blood
   Institute grant PO1HL-51971 and by the American Heart Association.
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NR 33
TC 103
Z9 111
U1 0
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0194-911X
EI 1524-4563
J9 HYPERTENSION
JI Hypertension
PD MAY
PY 2011
VL 57
IS 5
BP 918
EP U125
DI 10.1161/HYPERTENSIONAHA.110.161349
PG 17
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 752YA
UT WOS:000289730200018
PM 21422382
OA Bronze, Green Accepted
DA 2025-06-11
ER

PT J
AU Juvela, S
   Siironen, J
   Kuhmonen, J
AF Juvela, S
   Siironen, J
   Kuhmonen, J
TI Hyperglycemia, excess weight, and history of hypertension as risk
   factors for poor outcome and cerebral infarction after aneurysmal
   subarachnoid hemorrhage
SO JOURNAL OF NEUROSURGERY
LA English
DT Article
DE subarachnoid hemorrhage; cerebral infarction; hyperglycemia;
   hypertension; outcome
ID CASE-FATALITY RATES; ALCOHOL-CONSUMPTION; METABOLIC SYNDROME;
   BLOOD-PRESSURE; GLUCOSE-LEVELS; STROKE; SCALE
AB Object. Stress-induced hyperglycemia has been shown to be associated with poor outcome after aneurysmal subarachnoid hemorrhage (SAH). The authors prospectively tested whether hyperglycemia, independent of other factors, affects patient outcomes and the occurrence of cerebral infarction after SAH.
   Methods. Previous diseases, health habits, medications, clinical condition, and neuroimaging variables were recorded for 175 patients with SAH who were admitted to the hospital within 48 hours after bleeding. The plasma level of glucose was measured at admission and the fasting value of glucose was measured in the morning after aneurysm occlusion. Factors found to be independently predictive of patient outcomes at 3 months after SAH onset and the appearance of cerebral infarction were tested by performing multiple logistic regression.
   Plasma glucose values at admission were found to be associated with patient age, body mass index (BMI), history of hypertension, clinical condition, amount of subarachnoid or intraventricular blood, shunt-dependent hydrocephalus, outcome variables, and the appearance of cerebral infarction. When considered independently of age, clinical condition, or amount of subarachnoid, intraventricular, or intracerebral blood, the plasma glucose values at admission predicted poor outcome (per millimole/liter the odds ratio [OR] was 1.24 with a 95% confidence interval [CI] of 1.02-1.51). After an adjustment was made for the amount of subarachnoid blood, the clinical condition, and the duration of temporary artery occlusion during surgery, the BMI was found to be a significant predictor (per kilogram/square meter the OR was 1.15 with a 95% CI of 1.02-1.29) for the finding of cerebral infarction on the follow-up computerized tomography scan. Hypertension (OR 3.11, 95% CI 1. 1 1-8.73)-but not plasma glucose (OR 1.06, 95% CI 0.87-1.29)-also predicted the occurrence of infarction when tested instead of the BMI.
   Conclusions. Independent of the severity of bleeding, hyperglycemia at admission seems to impair outcome, and excess weight and hypertension appear to elevate the risk of cerebral infarction after SAH.
C1 Univ Helsinki, Cent Hosp, Dept Neurosurg, FI-00260 Helsinki, Finland.
C3 University of Helsinki; Helsinki University Central Hospital
RP Juvela, S (corresponding author), Univ Helsinki, Cent Hosp, Dept Neurosurg, Topeliuksenkatu 5, FI-00260 Helsinki, Finland.
EM seppo.juvela@helsinki.fi
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NR 20
TC 130
Z9 131
U1 1
U2 4
PU AMER ASSOC NEUROLOGICAL SURGEONS
PI CHARLOTTESVILLE
PA UNIV VIRGINIA, 1224 WEST MAIN ST, STE 450, CHARLOTTESVILLE, VA 22903 USA
SN 0022-3085
J9 J NEUROSURG
JI J. Neurosurg.
PD JUN
PY 2005
VL 102
IS 6
BP 998
EP 1003
DI 10.3171/jns.2005.102.6.0998
PG 6
WC Clinical Neurology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Surgery
GA 938NL
UT WOS:000230010000009
PM 16028757
DA 2025-06-11
ER

PT J
AU Abdollahi, S
   Vajdi, M
   Meshkini, F
   Vasmehjani, AA
   Sangsefidi, ZS
   Clark, CCT
   Soltani, S
AF Abdollahi, Shima
   Vajdi, Mahdi
   Meshkini, Fatemeh
   Vasmehjani, Azam Ahmadi
   Sangsefidi, Zohreh Sadat
   Clark, Cain C. T.
   Soltani, Sepideh
TI Resveratrol may mildly improve renal function in the general adult
   population: A systematic review and meta-analysis of randomized
   controlled clinical trials ?
SO NUTRITION RESEARCH
LA English
DT Review
DE Resveratrol; Uric acid; BUN; Creatinine; Kidney; Renal
ID DOUBLE-BLIND; KIDNEY-DISEASE; DIABETIC-NEPHROPATHY; INSULIN SENSITIVITY;
   METABOLIC SYNDROME; TRANS-RESVERATROL; OXIDATIVE STRESS;
   SUPPLEMENTATION; EXPRESSION; GLUCOSE
AB Whether renal health biomarkers can benefit from resveratrol supplements is unknown. Thus, we conducted a systematic review and meta-analysis to summarize evidence from randomized controlled trials investigating the effect of resveratrol supplementation on renal health biomarkers. We hypothesized that resveratrol supplementation is associated with improved renal health biomarkers. Four electronic databases, including PubMed, Scopus, and Institute for Scientific Information Web of Science, and Cochrane Central, were searched for relevant articles up to February 2023. The pooled effect sizes were estimated using a random effects model and expressed as weighted mean difference (WMD) and 95% CI. In total, 32 articles were eligible for inclusion in the current meta-analysis. The pooled results indicated that resveratrol significantly decreased blood urea nitrogen (weighted mean difference [WMD] = -0.84 mg/dL; 95% CI, -1.48 to -0.20; P = .01; I 2 = 64.4%) and creatinine levels (WMD = -1.90 mu mol/L; 95% CI, -3.59 to -0.21; P = .03; I 2 = 52.1%), and increased glomerular filtration rate (WMD = 7.58 mL/min/1.73 m 2 ; 95% CI, 5.25-9.91; P < .001; I 2 = 0%). The favor able change of blood urea nitrogen was significant in studies with short follow-up duration (12 weeks or less), with lower doses of resveratrol (less than 500 mg/d), and those conducted in patients with diabetes. However, higher doses of resveratrol are needed to observe significant reductions in creatinine. No significant change was observed in albumin, total protein, and uric acid concentrations. This meta-analysis provides a low certainty of evidence indicating a mild renal protective effect of resveratrol in adults. Further high-quality evidence in patients with impaired renal function and estimates of mortality risk in these patients is required before resveratrol can be advocated as an adjuvant therapy.
C1 [Abdollahi, Shima; Sangsefidi, Zohreh Sadat] North Khorasan Univ Med Sci, Sch Publ Hlth, Dept Nutr, Bojnurd, Iran.
   [Vajdi, Mahdi] Isfahan Univ Med Sci, Student Res Comm, Sch Nutr & Food Sci, Dept Clin Nutr, Esfahan, Iran.
   [Meshkini, Fatemeh] Shahid Sadoughi Univ Med Sci, Sch Med, Dept Biochem, Yazd, Iran.
   [Meshkini, Fatemeh] Shahid Sadoughi Univ Med Sci, Student Res Comm, Yazd, Iran.
   [Vasmehjani, Azam Ahmadi] Shahid Sadughi Univ Med Sci, Sch Publ Hlth, Dept Nutr, Yazd, Iran.
   [Clark, Cain C. T.] Coventry Univ, Ctr Intelligent Healthcare, Coventry CV1 5FB, England.
   [Soltani, Sepideh] Shahid Sadoughi Univ Med Sci, Noncommunicable Dis Res Inst, Yazd Cardiovasc Res Ctr, Yazd, Iran.
   [Soltani, Sepideh] Shahid Sadoughi Univ Med Sci, Noncommunicable Dis Res Inst, Yazd Cardiovasc Res Ctr, Yazd 8915173160, Iran.
C3 North Khorasan University of Medical Sciences; Isfahan University of
   Medical Sciences; Shahid Sadoughi University of Medical Sciences; Shahid
   Sadoughi University of Medical Sciences; Coventry University; Shahid
   Sadoughi University of Medical Sciences; Shahid Sadoughi University of
   Medical Sciences
RP Soltani, S (corresponding author), Shahid Sadoughi Univ Med Sci, Noncommunicable Dis Res Inst, Yazd Cardiovasc Res Ctr, Yazd 8915173160, Iran.
EM S.soltani1979@yahoo.com
RI Clark, Cain/I-4480-2019; Vajdi, Mahdi/GZG-7674-2022; Soltani,
   Sepideh/AAH-2679-2020; Sangsefidi, Zohreh Sadat/AAZ-7335-2021;
   Abdollahi, Shima/AAA-8999-2020
OI Soltani, Sepideh/0000-0002-1591-2569; Clark, Dr.
   Cain/0000-0002-6610-4617
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NR 102
TC 7
Z9 7
U1 0
U2 4
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0271-5317
EI 1879-0739
J9 NUTR RES
JI Nutr. Res.
PD MAY
PY 2023
VL 113
BP 1
EP 13
DI 10.1016/j.nutres.2023.03.002
EA MAR 2023
PG 13
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA D1WW1
UT WOS:000966702700001
PM 36996691
DA 2025-06-11
ER

PT J
AU Cheng, YC
   Li, YH
   Hsu, CY
   Lee, IT
AF Cheng, Yu-Cheng
   Li, Yu-Hsuan
   Hsu, Chiann-Yi
   Lee, I-Te
TI Synergistic Association of Carcinoembryonic Antigen and Carbohydrate
   Antigen 19-9 on the Risk of Abnormal Glucose Regulation
SO DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
LA English
DT Article
DE CA19-9; CEA; diabetes; prediabetes; tumor marker
ID TYPE-2 DIABETES-MELLITUS; CHRONIC KIDNEY-DISEASE; SERUM CA19-9 LEVELS;
   BETA-CELL FAILURE; INSULIN-RESISTANCE; OXIDATIVE STRESS; VITAMIN-D;
   ATHEROSCLEROSIS RISK; ADHESION MOLECULES; METABOLIC SYNDROME
AB Purpose: Carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9) are tumor-associated antigens. An increased serum level of CEA and CA19-9 separately has been reported in diabetes. In this study, we examined the composite effect of elevated serum levels of both CEA and CA19-9 on subjects with type 2 diabetes and prediabetes.
   Patients and Methods: A total of 3568 adults who attended a health examination were enrolled into this cross-sectional study. Subjects were grouped into four groups according to the median serum CEA and CA19-9 levels.
   Results: Subjects with high CEA and high CA19-9 levels had the highest proportions of diabetes (43.9%) and prediabetes (33.04%). There was a statistically significant trend in the proportion of diabetes across the four groups (P < 0.001). Multivariable logistic regression analysis revealed higher risks of type 2 diabetes in subjects with high CEA and low CA19-9 levels (odds ratio [OR] = 2.10, 95% confidence interval [CI]: 1.39-3.18, P < 0.001) and in those with high CA19-9 and low CEA levels (OR = 2.18, 95% CI: 1.42-3.34, P < 0.001) than in those with low CEA and low CA19-9 levels; among these four groups, the highest risk of type 2 diabetes was observed in subjects with high CEA and high CA19-9 levels (OR = 2.65, 95% CI: 1.81-3.88, P < 0.001). The risk of prediabetes was significantly higher only in subjects with high CEA and high CA19-9 levels compared to those with low CEA and low CA19-9 levels (OR = 1.32, 95% CI: 1.08-1.61, P = 0.006).
   Conclusion: CEA and CA19-9 had a synergistic ability to increase the risk of type 2 diabetes and prediabetes.
C1 [Cheng, Yu-Cheng; Li, Yu-Hsuan; Lee, I-Te] Taichung Vet Gen Hosp, Dept Internal Med, Div Endocrinol & Metab, Taichung, Taiwan.
   [Li, Yu-Hsuan] Taipei Med Univ, Grad Inst Data Sci, Taipei, Taiwan.
   [Hsu, Chiann-Yi] Biostat Task Force Taichung Vet Gen Hosp, Taichung, Taiwan.
   [Lee, I-Te] Natl Yang Ming Univ, Sch Med, Taipei, Taiwan.
   [Lee, I-Te] Chung Shan Med Univ, Sch Med, Taichung, Taiwan.
   [Lee, I-Te] Tunghai Univ, Coll Sci, Taichung, Taiwan.
C3 Taichung Veterans General Hospital; Taipei Medical University; National
   Yang Ming Chiao Tung University; Chung Shan Medical University; Tunghai
   University
RP Lee, IT (corresponding author), Taichung Vet Gen Hosp, Dept Internal Med, Div Endocrinol & Metab, Taichung, Taiwan.; Lee, IT (corresponding author), Natl Yang Ming Univ, Sch Med, Taipei, Taiwan.; Lee, IT (corresponding author), Chung Shan Med Univ, Sch Med, Taichung, Taiwan.; Lee, IT (corresponding author), Tunghai Univ, Coll Sci, Taichung, Taiwan.
EM itlee@vghtc.gov.tw
OI Cheng, Yu-Cheng/0000-0003-0980-2248
FU Ministry of Science and Technology, Taiwan [MOST 108-2314-B-075A-002];
   Taichung Veterans General Hospital, Taichung, Taiwan [TCVGH-1093505D]
FX This work was supported by a grant from the Ministry of Science and
   Technology, Taiwan (MOST 108-2314-B-075A-002), and Taichung Veterans
   General Hospital, Taichung, Taiwan (TCVGH-1093505D). The funders had no
   role in the decision to submit the manuscript for publication.
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NR 70
TC 3
Z9 3
U1 0
U2 8
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-7007
J9 DIABET METAB SYND OB
JI Diabetes Metab. Syndr. Obes.
PY 2020
VL 13
DI 10.2147/DMSO.S256223
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA LZ3CP
UT WOS:000541105400001
PM 32606853
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Darroudi, S
   Saberi-Karimian, M
   Tayefi, M
   Tayefi, B
   Khashyarmanesh, Z
   Fereydouni, N
   Haghighi, HM
   Mahmoudi, AA
   Kharazmi-Khorassani, J
   Gonoodi, K
   Esmaeili, H
   Mohammadpour, AH
   Ferns, GA
   Ghayour-Mobarhan, M
AF Darroudi, Susan
   Saberi-Karimian, Maryam
   Tayefi, Maryam
   Tayefi, Batool
   Khashyarmanesh, Zahra
   Fereydouni, Narges
   Haghighi, Hamideh Moalemzadeh
   Mahmoudi, Ali Asghar
   Kharazmi-Khorassani, Jasmine
   Gonoodi, Kayhan
   Esmaeili, Habibolah
   Mohammadpour, Amir Hooshang
   Ferns, Gordon A.
   Ghayour-Mobarhan, Majid
TI Association Between Hypertension in Healthy Participants and Zinc and
   Copper Status: a Population-Based Study
SO BIOLOGICAL TRACE ELEMENT RESEARCH
LA English
DT Article
DE Blood pressure; Hypertension; Micronutrient; Copper; Zinc
ID CORONARY-ARTERY-DISEASE; IRANIAN POPULATION; METABOLIC SYNDROME;
   BLOOD-PRESSURE; STRESS; CERULOPLASMIN; HOMOCYSTEINE; PREVALENCE
AB The prevalence of hypertension (HTN) is increasing globally. It has been shown that there is an association between micronutrient deficiency and HTN. In the current study, we aimed to assess the association between HTN with serum copper and zinc concentrations in a large representative Iranian population. The participants were enrolled into the Mashhad stroke and heart atherosclerotic disorders study (MASHAD study), a cohort study that was initiated in 2010. Anthropometric indices were assessed using standard procedures. Systolic (SBP) and diastolic (DBP) blood pressures were measured using a standard mercury sphygmomanometer. Fasting blood glucose (FBG), lipid profile, uric acid and blood urea nitrogen (BUN), and hs-CRP were measured using routine methods. HTN defined as persons who had SBP >= 130 mmHg and/or DBP >= 85 mmHg and/or medication use. Flame atomic absorption (Varian AA240FS) was used to measure serum Zn and Cu concentrations. SPSS software was used for all statistical analyses. A total of 9588 participants were recruited into the MASHAD study project. Participants were divided into two groups; 5695 healthy (non-hypertensive) (mean age 45.85 +/- 7.5 years) and 3893 hypertensive participants (mean age 51.18 +/- 7.67 years). Systolic (p < 0.001) and diastolic blood pressure (p < 0.001) were significantly different for different serum copper quartiles. The participants with serum copper levels < 80 mu g/dl had 1.33 times greater risk of an increased blood pressure than other participants. Participants with serum copper levels > 130 mu g/dl had a 1.94-fold higher risk of raised blood pressure. Serum zinc was not associated with systolic blood pressure, but individuals in the first quartile level of serum zinc had a diastolic blood pressure that was significantly higher than other quartiles (p = 0.035). Serum copper is associated with blood pressure status in adults in a U-shaped relationship, with a range of serum copper between 80 and 130 mu g/dl being associated with normal blood pressure.
C1 [Darroudi, Susan; Saberi-Karimian, Maryam; Fereydouni, Narges; Kharazmi-Khorassani, Jasmine] Mashhad Univ Med Sci, Sch Med, Dept Modern Sci & Technol, Mol Med Grp, Mashhad, Razavi Khorasan, Iran.
   [Tayefi, Maryam] MUMS, Imam Reza Hosp, Dept Cardiovasc, Mashhad, Razavi Khorasan, Iran.
   [Tayefi, Maryam] Mashhad Univ Med Sci, Univ Int Accreditat, Int Off, Clin Res Unit, Mashhad, Razavi Khorasan, Iran.
   [Tayefi, Batool] Iran Univ Med Sci, Prevent Med & Publ Hlth Res Ctr, Tehran, Iran.
   [Khashyarmanesh, Zahra; Haghighi, Hamideh Moalemzadeh] Mashhad Univ Med Sci, Sch Pharmacol, Dept Med Chem, Mashhad, Razavi Khorasan, Iran.
   [Mahmoudi, Ali Asghar] Hlth Ctr 2, Mashhad, Razavi Khorasan, Iran.
   [Gonoodi, Kayhan] Mashhad Univ Med Sci, Fac Med, Dept Nutr, Mashhad, Razavi Khorasan, Iran.
   [Esmaeili, Habibolah] Mashhad Univ Med Sci, Sch Hlth, Dept Biostat, Mashhad, Razavi Khorasan, Iran.
   [Mohammadpour, Amir Hooshang] Mashhad Univ Med Sci, Sch Pharm, Dept Clin Pharm, Mashhad, Razavi Khorasan, Iran.
   [Mohammadpour, Amir Hooshang] Mashhad Univ Med Sci, Pharmaceut Inst Technol, Pharmaceut Res Ctr, POB 91775-1365, Mashhad, Razavi Khorasan, Iran.
   [Ferns, Gordon A.] Brighton & Sussex Med Sch, Div Med Educ, Brighton BN1 9PH, Sussex, England.
   [Ghayour-Mobarhan, Majid] Mashhad Univ Med Sci, Sch Med, Metab Syndrome Res Ctr, Mashhad, Razavi Khorasan, Iran.
   [Ghayour-Mobarhan, Majid] Mashhad Univ Med Sci, Sch Med, Biochem Nutr Res Ctr, Mashhad 9919991766, Razavi Khorasan, Iran.
C3 Mashhad University of Medical Sciences; Mashhad University of Medical
   Sciences; Mashhad University of Medical Sciences; Iran University of
   Medical Sciences; Mashhad University of Medical Sciences; Mashhad
   University of Medical Sciences; Mashhad University of Medical Sciences;
   Mashhad University of Medical Sciences; Mashhad University of Medical
   Sciences; University of Brighton; University of Sussex; Mashhad
   University of Medical Sciences; Mashhad University of Medical Sciences
RP Mohammadpour, AH (corresponding author), Mashhad Univ Med Sci, Sch Pharm, Dept Clin Pharm, Mashhad, Razavi Khorasan, Iran.; Mohammadpour, AH (corresponding author), Mashhad Univ Med Sci, Pharmaceut Inst Technol, Pharmaceut Res Ctr, POB 91775-1365, Mashhad, Razavi Khorasan, Iran.; Ghayour-Mobarhan, M (corresponding author), Mashhad Univ Med Sci, Sch Med, Metab Syndrome Res Ctr, Mashhad, Razavi Khorasan, Iran.; Ghayour-Mobarhan, M (corresponding author), Mashhad Univ Med Sci, Sch Med, Biochem Nutr Res Ctr, Mashhad 9919991766, Razavi Khorasan, Iran.
EM mohamadpoorah@mums.ac.ir; ghayourm@mums.ac.ir
RI Tayefi Nasrabadi, Batool/U-7014-2019; Fereydouni, Narges/ABD-8931-2020;
   Ghayour-Mobarhan, Majid/AAY-5963-2020
OI Tayefi Nasrabadi, Batool/0000-0002-0913-7324; tayefi,
   maryam/0000-0003-4637-7754; kharazmi-khorassani,
   Jasmin/0000-0001-5472-7916
FU Mashhad University of Medical Science
FX This study was support by grant from Mashhad University of Medical
   Science.
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NR 33
TC 35
Z9 36
U1 0
U2 10
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0163-4984
EI 1559-0720
J9 BIOL TRACE ELEM RES
JI Biol. Trace Elem. Res.
PD JUL
PY 2019
VL 190
IS 1
BP 38
EP 44
DI 10.1007/s12011-018-1518-4
PG 7
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA HZ3PG
UT WOS:000468760200005
PM 30267309
DA 2025-06-11
ER

PT J
AU Ebrahimi-Mameghani, M
   Sadeghi, Z
   Farhangi, MA
   Vaghef-Mehrabany, E
   Aliashrafi, S
AF Ebrahimi-Mameghani, Mehrangiz
   Sadeghi, Zahra
   Farhangi, Mandieh Abbasalizad
   Vaghef-Mehrabany, Elnaz
   Aliashrafi, Soodabeh
TI Glucose homeostasis, insulin resistance and inflammatory biomarkers in
   patients with non-alcoholic fatty liver disease: Beneficial effects of
   supplementation with microalgae Chlorella vulgaris: A
   double-blind placebo-controlled randomized clinical trial
SO CLINICAL NUTRITION
LA English
DT Article
DE Chlorella vulgaris; Non-alcoholic fatty liver disease; Inflammation;
   Insulin resistance
ID OXIDATIVE STRESS; PREVALENCE; STEATOSIS; DIAGNOSIS; THERAPY
AB Background: Chlorella vulgaris (C. vulgaris) is reported to improve dyslipidemia and hypertension; however, its effect on inflammatory biomarkers and insulin resistance has not been noticed thus far. Non-alcoholic fatty liver disease (NAFLD) as a hepatic symptom of metabolic syndrome is strongly associated with insulin resistance and inflammation.
   Aim of the study: In the current interventional trial, we aimed to study the effects of C. vulgaris supplementation on glucose homeostasis, insulin resistance and inflammatory biomarkers in patients with NAFLD.
   Methods: Seventy NAFLD patients confirmed by ultra-sonographic findings were randomly assigned into intervention group (four 300 mg tablets of C. vulgaris) or placebo group (four 300 mg tablets of placebos) for 8 weeks. Anthropometric measurements, liver enzymes, fasting serum glucose (FSG), insulin, high sensitive C-reactive protein (hs-CRP) and tumor necrosis factor-alpha (TNF-alpha) were assessed and homeostatic model assessment (HOMA) score for insulin resistance was estimated before and after the intervention.
   Results: Anthropometric measurements decreased significantly in both group (p < 0.001). However, mean reduction in weight was significantly higher in C. vulgaris - treated group compared to placebo group. Serum concentrations of liver enzymes, FSG and hs-CRP also significantly decreased and serum insulin concentration and HOMA score increased significantly only in C. vulgaris-treated group (P < 0.001, P < 0.006 and P < 0.025, respectively). Mean change in serum glucose and TNF-alpha levels were significant between the groups even after adjusting for the serum insulin and baseline values of variables (P = 0.014, P = 0.005, P = 0.014, respectively); between-group differences were not significant for the other variables by the end of study.
   Conclusion: To our finding, C. vulgaris supplementation could be considered as an adjunctive therapy to decrease weight and improve glycemic status and reducing hs-CRP as well as improving liver function in patients with NAFLD.
   IRCT number: 201202233320N7. (C) 2016 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.
C1 [Ebrahimi-Mameghani, Mehrangiz] Tabriz Univ Med Sci, Sch Nutr, Nutr Res Ctr, Tabriz, Iran.
   [Sadeghi, Zahra] Univ Payamnoor, Mashhad, Iran.
   [Farhangi, Mandieh Abbasalizad] Tabriz Univ Med Sci, Sch Nutr, Tabriz, Iran.
   [Vaghef-Mehrabany, Elnaz; Aliashrafi, Soodabeh] Tabriz Univ Med Sci, Fac Nutr & Food Sci, Student Res Comm, Tabriz, Iran.
C3 Tabriz University of Medical Science; Tabriz University of Medical
   Science; Tabriz University of Medical Science
RP Aliashrafi, S (corresponding author), Tabriz Univ Med Sci, Fac Nutr & Food Sci, Student Res Comm, Tabriz, Iran.
EM SA.NUT89@yahoo.com
RI Farhangi, Mahdieh/AAC-6758-2019; Aliashrafi, Soodabeh/AAA-1337-2020;
   Ebrahimi-Mameghani, Mehrangiz/G-6461-2017
OI Ebrahimi-Mameghani, Mehrangiz/0000-0002-0311-1289
FU Nutrition Research Center, Research Deputy and Student Research
   Committee of Tabriz University of Medical Sciences [5.71.433]
FX We kindly acknowledge Nutrition Research Center, Research Deputy and
   Student Research Committee of Tabriz University of Medical Sciences (No.
   5.71.433) for their financial support. This article is provided from
   MSc. Thesis with registered number at Tabriz University of Medical
   Sciences. Also, the authors appreciate Iranians Green Future Co.
   (Tehran, Iran) for providing C. vulgaris tablets.
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NR 31
TC 55
Z9 59
U1 4
U2 25
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0261-5614
EI 1532-1983
J9 CLIN NUTR
JI Clin. Nutr.
PD AUG
PY 2017
VL 36
IS 4
BP 1001
EP 1006
DI 10.1016/j.clnu.2016.07.004
PG 6
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA EY9JP
UT WOS:000404315200009
PM 27475283
DA 2025-06-11
ER

PT J
AU Le-Ha, C
   Herbison, CE
   Beilin, LJ
   Burrows, S
   Henley, DE
   Lye, SJ
   Matthews, SG
   Pennell, CE
   Mori, TA
AF Le-Ha, Chi
   Herbison, Carly E.
   Beilin, Lawrence J.
   Burrows, Sally
   Henley, David E.
   Lye, Stephen J.
   Matthews, Stephen G.
   Pennell, Craig E.
   Mori, Trevor A.
TI Hypothalamic-pituitary-adrenal axis activity under resting conditions
   and cardiovascular risk factors in adolescents
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE HPA axis activity; Cortisol; Corticosteroid binding globulin;
   Cardiovascular risk factors; Adolescence
ID CORTICOSTEROID-BINDING GLOBULIN; CORTISOL AWAKENING RESPONSE; SALIVARY
   CORTISOL; METABOLIC SYNDROME; SERUM CORTISOL; LATINO YOUTH; DISEASE;
   ATHEROSCLEROSIS; STRESS; ASSOCIATION
AB Background: Activation of the hypothalamic-pituitary-adrenal (HPA) axis has been associated with higher levels of cardiovascular (CVD) risk factors in adults. This study aimed to assess the relation between measures of HPA axis activity under resting conditions and CVD risk factors in a general population of adolescents at 17 years.
   Methods: A total of 1134 adolescents from the Western Australian Pregnancy Cohort (Raine) Study had phenotypic and socio-demographic data. The associations between HPA axis measures (plasma ACTH, total cortisol, calculated free cortisol, corticosteroid binding globulin (CBG), and salivary cortisol) and a range of cardiovascular risk factors were examined using multivariable linear regression models, with adjustment for gender, adiposity, birth weight, gestational age, and sodo-behavioural factors.
   Results: Plasma total cortisol was positively associated with systolic blood pressure (SBP) (p = 0.011), total cholesterol, HDL-cholesterol, and triglycerides (all p < 0.001), and hs-CRP (p = 0.047). Salivary cortisol was associated positively with HDL-C (p = 0.033) and negatively with LDL-cholesterol (p = 0.016); plasma calculated free cortisol was positively associated with triglycerides (p = 0.006); plasma CBG was positively associated with total cholesterol and HDL-cholesterol (both p < 0.001), LDL-cholesterol (p = 0.022), and hs-CRP (p = 0.001). After correction for multiple comparisons, significant associations remained for total cortisol with total cholesterol, HDL-C, and triglycerides; for calculated free cortisol with triglycerides; and for CBG with HDL-C, total cholesterol, and hs-CRP. Plasma ACTH was not associated with any cardiovascular risk factor. There was no association between BMI and any measure of HPA axis activity.
   Conclusion: In an adolescent population, HPA axis measures under resting conditions are associated with a range of CVD risk factors. Clarification of the mechanisms underlying these associations in adolescence would be an important step in understanding the evolution of adult CVD. (C) 2016 Elsevier Ltd. All rights reserved.
C1 [Le-Ha, Chi; Beilin, Lawrence J.; Burrows, Sally; Henley, David E.; Mori, Trevor A.] Univ Western Australia, Sch Med & Pharmacol, Nedlands, WA 6009, Australia.
   [Herbison, Carly E.; Pennell, Craig E.] Univ Western Australia, Sch Womens & Infants Hlth, Nedlands, WA 6009, Australia.
   [Henley, David E.] Sir Charles Gairdner Hosp, Dept Endocrinol & Diabet, Nedlands, WA 6009, Australia.
   [Lye, Stephen J.] Mt Sinai Hosp, Samuel Lunenfeld Res Inst, 600 Univ Ave, Toronto, ON M5G 1X5, Canada.
   [Matthews, Stephen G.] Univ Toronto, Dept Physiol, Toronto, ON M5S 1A1, Canada.
C3 University of Western Australia; University of Western Australia;
   University of Western Australia; Sir Charles Gairdner Hospital;
   University of Toronto; Sinai Health System Toronto; Lunenfeld Tanenbaum
   Research Institute; University of Toronto
RP Le-Ha, C (corresponding author), Royal Perth Hosp Unit, Sch Med & Pharmacol, GPO Box X2213, Perth, WA 6847, Australia.
EM cleha@meddent.uwa.edu.au
RI Mori, Trevor/H-5485-2014; Matthews, Stephen/N-7555-2018; Lye,
   Stephen/E-7269-2013; Pennell, Craig/ABD-6902-2020; Burrows,
   Sally/H-8914-2014; Pennell, Craig/C-5190-2011
OI Matthews, Stephen/0000-0002-9654-9940; Burrows,
   Sally/0000-0002-8499-4537; Beilin, Lawrence/0000-0003-4853-7360;
   Pennell, Craig/0000-0002-0937-6165; Mori, Trevor A/0000-0002-5264-9229;
   McLaughlin, Carly/0000-0003-2514-9330; Le-Ha, Chi/0000-0003-2459-6673
FU National Health and Medical Research Council of Australia [353514,
   403981, 458623]; Canadian Institutes of Health Research [MOP 82893];
   University of Western Australia (UWA); Raine Medical Research
   Foundation; Telethon Kids Institute; UWA Faculty of Medicine, Dentistry
   and Health Sciences; Women and Infants Research Foundation; Curtin
   University; Edith Cowan University; Australian Government; Raine Study
   PhD Scholarship
FX We are thankful to the Raine Study adolescents and their families, the
   Raine Study Team for cohort co-ordination and data collection, and Ms
   Lynette McCahon for technical assistance. We acknowledge the support of
   the National Health and Medical Research Council of Australia (Program
   grant 353514 and Project grants 403981 and 458623), and the Canadian
   Institutes of Health Research (Grant MOP 82893). Core management of the
   Raine Study is funded by the University of Western Australia (UWA); the
   Raine Medical Research Foundation; the Telethon Kids Institute; the UWA
   Faculty of Medicine, Dentistry and Health Sciences; the Women and
   Infants Research Foundation; Curtin University and Edith Cowan
   University. Dr Le-Ha was supported by an Endeavour Postgraduate Award
   from the Australian Government, and a Raine Study PhD Scholarship.
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NR 45
TC 16
Z9 19
U1 0
U2 10
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD APR
PY 2016
VL 66
BP 118
EP 124
DI 10.1016/j.psyneuen.2016.01.002
PG 7
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA DH4OG
UT WOS:000372764700014
PM 26802599
DA 2025-06-11
ER

PT J
AU Amin, MM
   Asaad, GF
   Salam, RMA
   El-Abhar, HS
   Arbid, MS
AF Amin, Mohamed M.
   Asaad, Gihan F.
   Salam, Rania M. Abdel
   El-Abhar, Hanan S.
   Arbid, Mahmoud S.
TI Novel CoQ10 Antidiabetic Mechanisms Underlie Its Positive Effect:
   Modulation of Insulin and Adiponectine Receptors, Tyrosine Kinase, PI3K,
   Glucose Transporters, sRAGE and Visfatin in Insulin Resistant/Diabetic
   Rats
SO PLOS ONE
LA English
DT Article
ID ENDOGENOUS SECRETORY RAGE; BETA-CELL FUNCTION; COENZYME Q(10);
   SKELETAL-MUSCLE; MESSENGER-RNA; METABOLIC SYNDROME; OXIDATIVE STRESS;
   GLYCEMIC CONTROL; SOLUBLE RAGE; VISCERAL FAT
AB As a nutritional supplement, coenzyme Q10 (CoQ10) was tested previously in several models of diabetes and/or insulin resistance (IR); however, its exact mechanisms have not been profoundly explicated. Hence, the objective of this work is to verify some of the possible mechanisms that underlie its therapeutic efficacy. Moreover, the study aimed to assess the potential modulatory effect of CoQ10 on the antidiabetic action of glimebiride. An insulin resistance/type 2 diabetic model was adopted, in which rats were fed high fat/high fructose diet (HFFD) for 6 weeks followed by a single sub-diabetogenic dose of streptozotocin (35 mg/kg, i. p.). At the end of the 7 th week animals were treated with CoQ10 (20 mg/kg, p. o) and/or glimebiride (0.5 mg/kg, p. o) for 2 weeks. CoQ10 alone opposed the HFFD effect and increased the hepatic/muscular content/activity of tyrosine kinase (TK), phosphatidylinositol kinase (PI3K), and adiponectin receptors. Conversely, it decreased the content/activity of insulin receptor isoforms, myeloperoxidase and glucose transporters (GLUT4; 2). Besides, it lowered significantly the serum levels of glucose, insulin, fructosamine and HOMA index, improved the serum lipid panel and elevated the levels of glutathione, sRAGE and adiponectin. On the other hand, CoQ10 lowered the serum levels of malondialdehyde, visfatin, ALT and AST. Surprisingly, CoQ10 effect surpassed that of glimepiride in almost all the assessed parameters, except for glucose, fructosamine, TK, PI3K, and GLUT4. Combining CoQ10 with glimepiride enhanced the effect of the latter on the aforementioned parameters. Conclusion: These results provided a new insight into the possible mechanisms by which CoQ10 improves insulin sensitivity and adjusts type 2 diabetic disorder. These mechanisms involve modulation of insulin and adiponectin receptors, as well as TK, PI3K, glucose transporters, besides improving lipid profile, redox system, sRAGE, and adipocytokines. The study also points to the potential positive effect of CoQ10 as an adds-on to conventional antidiabetic therapies.
C1 [Salam, Rania M. Abdel; El-Abhar, Hanan S.] Cairo Univ, Fac Pharm, Dept Pharmacol & Toxicol, Cairo, Egypt.
   [Amin, Mohamed M.; Asaad, Gihan F.; Arbid, Mahmoud S.] Natl Res Ctr, Div Med, Dept Pharmacol, Cairo, Egypt.
C3 Egyptian Knowledge Bank (EKB); Cairo University; Egyptian Knowledge Bank
   (EKB); National Research Centre (NRC)
RP El-Abhar, HS (corresponding author), Cairo Univ, Fac Pharm, Dept Pharmacol & Toxicol, Cairo, Egypt.
EM Hanabhar@yahoo.com
RI Abdelsalam, rania/IQS-3961-2023; El-Abhar, Hanan/L-2289-2019; Amin,
   Mohamed/O-2396-2018; Asaad, Gihan F./AAB-8649-2022
OI Abd El Salam, Rania/0000-0003-4623-8754; , Gihan/0000-0002-8017-6668;
   Amin, Mohamed/0000-0002-3602-5555; Arbid, Mahmoud/0000-0002-6773-3650;
   Asaad, Gihan F./0000-0002-7679-5968
FU NOAA Ocean Acidification Program, NOAA Pacific Marine Environmental
   Laboratory; University of Washington including the PRISM program;
   Washington State Department of Ecology; Hood Canal Dissolved Oxygen
   Program via Naval Sea Systems Command [N00024-02-D-6602 Task 50];
   National Research Fellowship award; National Oceanic and Atmospheric
   Administration's Northwest Fisheries Science Center, Pacific Marine
   Environmental Laboratory, Ocean Acidification Program, and Integrated
   Ocean Observing System Program; University of Washington, including
   Northwest Association of Networked Ocean Observing Systems (NANOOS),
   Puget Sound Regional Synthesis Model (PRISM), Applied Physics
   Laboratory, and School of Oceanography
FX This research was supported by the NOAA Ocean Acidification Program,
   NOAA Pacific Marine Environmental Laboratory, the University of
   Washington including the PRISM program, and the Washington State
   Department of Ecology. Work in Hood Canal was partially funded through
   the Hood Canal Dissolved Oxygen Program via Naval Sea Systems Command
   Contract # N00024-02-D-6602 Task 50. J. C. P. R was supported by a
   National Research Fellowship award. This work was co-sponsored by the
   National Oceanic and Atmospheric Administration's Northwest Fisheries
   Science Center, Pacific Marine Environmental Laboratory, Ocean
   Acidification Program, and Integrated Ocean Observing System Program;
   the University of Washington, including Northwest Association of
   Networked Ocean Observing Systems (NANOOS), Puget Sound Regional
   Synthesis Model (PRISM), Applied Physics Laboratory, and School of
   Oceanography; and the Washington State Department of Ecology. Work in
   Hood Canal was partially funded through the Hood Canal Dissolved Oxygen
   Program via Naval Sea Systems Command Contract # N00024-02-D-6602 Task
   50. The funders had no role in study design, data collection and
   analysis, decision to publish, or preparation of the manuscript.
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NR 74
TC 66
Z9 67
U1 0
U2 28
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD FEB 20
PY 2014
VL 9
IS 2
AR e89169
DI 10.1371/journal.pone.0089169
PG 12
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA AB3UC
UT WOS:000331714700068
PM 24586567
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Coskun, A
   Arikan, T
   Kilinc, M
   Arikan, DC
   Ekerbiçer, HC
AF Coskun, Ayhan
   Arikan, Tugba
   Kilinc, Metin
   Arikan, Deniz Cemgil
   Ekerbicer, Hasan Cetin
TI Plasma selenium levels in Turkish women with polycystic ovary syndrome
SO EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
LA English
DT Article
DE PCOS; Selenium; Antioxidant; Turkish women
ID THECA-INTERSTITIAL CELLS; TOTAL ANTIOXIDANT STATUS; ACUTE-PHASE
   RESPONSE; OXIDATIVE STRESS; CARDIOVASCULAR-DISEASE; INSULIN-RESISTANCE;
   SERUM SELENIUM; ENDOTHELIAL DYSFUNCTION; PARAOXONASE ACTIVITY; METABOLIC
   SYNDROME
AB Objective(s): To evaluate selenium (Se) levels in serum and their relation with hyperandrogenism and insulin resistance (IR) in women with polycystic ovary syndrome (PCOS) and in control subjects.
   Study design: Women with any gynecological problem who presented to the Kahramanmaras Sutcuimam University Medical Faculty Gynecology and Obstetric Outpatient Clinic were invited to participate. Group 1 consisted of 36 cases with a diagnosis of PCOS according to the 2003 Rotterdam Consensus Criteria, and Group 2 (control group) consisted of 33 age- and BMI-matched healthy women. In all cases, serum total testosterone (tT), dihydroepiandrostenedione-sulfate (DHEAS), follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), insulin, glucose (mg/dL), total cholesterol (TC) (mg/dL), high density lipoprotein-cholesterol (HDL-C) (mg/dL), low density lipoprotein-cholesterol (LDL-C) (mg/dL), triglyceride (TG) (mg/dL) and Se levels were measured.
   Results: The level of FSH was significantly lower, and the levels of LH, E2, tT, and DHEAS were significantly higher in group 1 than in group 2 (p < 0.05). The hirsutism score was significantly higher among PCOS women compared to the control group (p < 0.05). Although insulin levels and HOMA-IR were markedly increased in the PCOS group compared to the control group, the differences were not significant (p > 0.05). The plasma Se level was significantly lower in PCOS women compared to the control group (p < 0.05). When we combined the all women in two groups, regarding them as one group (combined group, n = 69), a negative correlation between Se and LH and tT was present (p < 0.05).
   Conclusion(s): Our results show decreased plasma concentrations of Se and a negative correlation between Se and LH, tT in women with PCOS. These results indicate that Se May play a role in the pathogenesis of PCOS related with hyperandrogenism. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
C1 [Coskun, Ayhan; Arikan, Deniz Cemgil] Kahramanmaras Sutcu Imam Univ, Tip Fak, Kadin Hastaliklari & Dogum Anabilim Dali, TR-46050 Kahramanmaras, Turkey.
   [Arikan, Tugba] Kahramanmaras Sutcu Imam Univ, Fac Educ, Dept Sci Teaching, TR-46050 Kahramanmaras, Turkey.
   [Kilinc, Metin] Kahramanmaras Sutcu Imam Univ, Fac Med, Dept Biochem, TR-46050 Kahramanmaras, Turkey.
   [Ekerbicer, Hasan Cetin] Kahramanmaras Sutcu Imam Univ, Fac Med, Dept Publ Hlth, TR-46050 Kahramanmaras, Turkey.
C3 Kahramanmaras Sutcu Imam University; Kahramanmaras Sutcu Imam
   University; Kahramanmaras Sutcu Imam University; Kahramanmaras Sutcu
   Imam University
RP Coskun, A (corresponding author), Kahramanmaras Sutcu Imam Univ, Tip Fak, Kadin Hastaliklari & Dogum Anabilim Dali, Yoruk Selim Mah Hastane Cad 32, TR-46050 Kahramanmaras, Turkey.
EM drayhancoskun@hotmail.com
RI Ekerbiçer, Hasan Çetin/HHT-0237-2022
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NR 49
TC 53
Z9 54
U1 0
U2 28
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0301-2115
J9 EUR J OBSTET GYN R B
JI Eur. J. Obstet. Gynecol. Reprod. Biol.
PD JUN
PY 2013
VL 168
IS 2
BP 183
EP 186
DI 10.1016/j.ejogrb.2013.01.021
PG 4
WC Obstetrics & Gynecology; Reproductive Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology; Reproductive Biology
GA 170EZ
UT WOS:000320834500012
PM 23490536
DA 2025-06-11
ER

PT J
AU Rhee, SD
   Kim, CH
   Park, JS
   Jung, WH
   Park, SB
   Kim, HY
   Bae, GH
   Kim, TJ
   Kim, KY
AF Rhee, Sang Dal
   Kim, Chi-Hyun
   Park, Ji Seon
   Jung, Won Hoon
   Park, Sung Bum
   Kim, Hee Youn
   Bae, Gyu Hwan
   Kim, Ta Jan
   Kim, Ki Young
TI Carbenoxolone prevents the development of fatty liver in
   C57BL/6-Lep<SUP>ob/ob</SUP> mice via the inhibition of
   sterol regulatory element binding protein-1c activity and apoptosis
SO EUROPEAN JOURNAL OF PHARMACOLOGY
LA English
DT Article
DE Fatty liver; Sterol regulatory element binding protein-1c; Inflammation;
   Reactive oxygen species; Apoptosis
ID 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1; DIET-INDUCED OBESITY;
   HEPATIC STEATOSIS; INSULIN-RESISTANCE; METABOLIC SYNDROME; OXIDATIVE
   STRESS; ADIPOGENESIS; MITOCHONDRIA; STEATOHEPATITIS; LIPOGENESIS
AB Carbenoxolone is the 3-hemisuccinate of glycyrrhetinic acid, the active principal of licorice (Glycyrrhiza glabra). It was reported that carbenoxolone improved glucose tolerance with increased insulin sensitivity in mice with high fat diet-induced obesity. In the present study, we elucidated the protective effect of carbenoxolone in fatty liver animal models of C57BL/6-Lep(ob/ob) mice through inhibition of hepatic lipogenesis and apoptosis. In addition, the potential mechanisms by which carbenoxolone could exert such protection were elucidated. Carbenoxolone was daily administrated by gavage for 28 days in C57BL/6 and C57BL/6-Lep(ob/ob) mice. Carbenoxolone prevented the plasma triglyceride and free fatty acid accumulation associated with the reduction of the expression of sterol regulatory element binding protein-1c, liver X receptor, fatty acid synthase and acethyl-CoA carboxylase in the livers of C57BL/6-Lep(ob/ob) mice. Carbenoxolone also prevented hepatic injury through anti-apoptotic action in the livers of C57BL/6-Lep(ob/ob) mice, accompanied by increased Bcl-2 expression and suppressed Bax and cytochrome c expression. As a mechanism, increased inflammatory cytokine expressions were inhibited by carbenoxolone in the fatty livers of C57BL/6-Lep(ob/ob) mice. Furthermore, carbenoxolone inhibited free fatty acid (oleate/palmitate) induced reactive oxygen species formation and reversed free fatty acid induced mitochondrial membrane depolarization in HepG2 cells. Carbenoxolone prevents the development of fatty liver by inhibiting sterol regulatory element binding protein-1c expression and activity with an anti-apoptotic mechanism via the inhibition of inflammatory cytokine and reactive oxygen species formation in the livers of C57BL/6-Lep(ob/ob) mice. It is suggested that carbenoxolone prevents the development and progression of fatty liver disease in patients with insulin resistance. (c) 2012 Elsevier B.V. All rights reserved.
C1 [Rhee, Sang Dal; Kim, Chi-Hyun; Park, Ji Seon; Jung, Won Hoon; Park, Sung Bum; Kim, Hee Youn; Bae, Gyu Hwan; Kim, Ta Jan; Kim, Ki Young] Korea Res Inst Chem Technol, Bioorgan Sci Div, Taejon 305600, South Korea.
   [Park, Sung Bum] Chungnam Natl Univ, Coll Pharm, Dept Toxicol, Taejon 305764, South Korea.
C3 Korea Research Institute of Chemical Technology (KRICT); Chungnam
   National University
RP Kim, KY (corresponding author), Korea Res Inst Chem Technol, Bioorgan Sci Div, POB 107, Taejon 305600, South Korea.
EM kykim@krict.re.kr
RI Park, Jin-Young/HDN-0483-2022; Kim, Yun Hak/ABF-3331-2021; Kim,
   Kyung-Min Kim/C-7007-2014; Park, Joohyun/KAL-8175-2024
FU Center for Biological Modulators of the 21st Century Frontier RD
   Program; Ministry of Education, Science and Technology; Ministry of
   Knowledge Economy, Korea; Korea Research Institute of Chemical
   Technology
FX This research was supported by the Center for Biological Modulators of
   the 21st Century Frontier R&D Program, the Ministry of Education,
   Science and Technology, and the Ministry of Knowledge Economy, Korea and
   the Korea Research Institute of Chemical Technology.
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NR 31
TC 24
Z9 26
U1 0
U2 11
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0014-2999
EI 1879-0712
J9 EUR J PHARMACOL
JI Eur. J. Pharmacol.
PD SEP 15
PY 2012
VL 691
IS 1-3
BP 9
EP 18
DI 10.1016/j.ejphar.2012.06.021
PG 10
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 992XZ
UT WOS:000307815800002
PM 22742899
DA 2025-06-11
ER

PT J
AU Savonen, K
   Krachler, B
   Hassinen, M
   Komulainen, P
   Kiviniemi, V
   Lakka, TA
   Rauramaa, R
AF Savonen, K.
   Krachler, B.
   Hassinen, M.
   Komulainen, P.
   Kiviniemi, V.
   Lakka, T. A.
   Rauramaa, R.
TI The current standard measure of cardiorespiratory fitness introduces
   confounding by body mass: the DR's EXTRA study
SO INTERNATIONAL JOURNAL OF OBESITY
LA English
DT Article
DE abnormal glucose metabolism; body mass; cardiorespiratory fitness;
   maximal oxygen uptake
ID ACTIVITY ENERGY-EXPENDITURE; METABOLIC SYNDROME; PHYSICAL-ACTIVITY;
   OXYGEN-UPTAKE; EXERCISE; SIZE; ASSOCIATION; CAPACITY; WEIGHT; ADULTS
AB OBJECTIVE: Cardiorespiratory fitness is currently estimated by dividing maximal oxygen consumption (VO2max) by body weight (per-weight standard). However, the statistically correct way to neutralize the effect of weight on VO2max in a given population is adjustment for body weight by regression techniques (adjusted standard). Our objective is to quantify the bias introduced by the per-weight standard in a population distributed across different categories of body mass.
   DESIGN: This is a cross-sectional study.
   SUBJECTS AND METHODS: Baseline measures from participants of the Dose-Responses to Exercise Training Study (DR's EXTRA), 635 men (body mass index (BMI): 19-47 kgm(-2)) and 638 women (BMI: 16-49 kgm(-2)) aged 57-78 years who performed oral glucose tolerance tests and maximal exercise stress tests with direct measurement of VO2max. We compare the increase in VO2max implied by the per-weight standard with the real increase of VO2max per kg body weight. A linear logistic regression model estimates odds for abnormal glucose metabolism (either impaired fasting glycemia or impaired glucose tolerance or Type 2 diabetes) of the least-fit versus most-fit quartile according to both per-weight standard and adjusted standard.
   RESULTS: The per-weight standard implies an increase of VO2max with 20.9 ml min(-1) in women and 26.4 ml min(-1) in men per additional kg body weight. The true increase per kg is only 7.0 ml min(-1) (95% confidence interval: 5.3-8.8) and 8.0 ml min(-1) (95% confidence interval: 5.3-10.7), respectively. Risk for abnormal glucose metabolism in the least-fit quartile of the population is overestimated by 52% if the per-weight standard is used.
   CONCLUSIONS: In comparisons across different categories of body mass, the per-weight standard systematically underestimates cardiorespiratory fitness in obese subjects. Use of the per-weight standard markedly inflates associations between poor fitness and co-morbidities of obesity.
C1 [Savonen, K.; Krachler, B.; Hassinen, M.; Komulainen, P.; Lakka, T. A.; Rauramaa, R.] Kuopio Res Inst Exercise Med, Kuopio 70100, Finland.
   [Savonen, K.; Rauramaa, R.] Kuopio Univ Hosp, Dept Clin Physiol & Nucl Med, SF-70210 Kuopio, Finland.
   [Krachler, B.] Umea Univ, Dept Publ Hlth & Clin Med, Umea, Sweden.
   [Kiviniemi, V.] Univ Eastern Finland, Informat Technol Ctr, Kuopio, Finland.
   [Lakka, T. A.] Univ Eastern Finland, Inst Biomed Physiol, Kuopio, Finland.
C3 University of Eastern Finland; University of Eastern Finland Hospital;
   Kuopio University Hospital; Umea University; University of Eastern
   Finland; University of Eastern Finland
RP Rauramaa, R (corresponding author), Kuopio Res Inst Exercise Med, Haapaniementie 16, Kuopio 70100, Finland.
EM Rainer.Rauramaa@uef.fi
RI Komulainen, Pirjo/MVY-1409-2025
OI Krachler, Benno/0000-0002-4209-9999; Lakka, Timo/0000-0002-9199-2871
FU Ministry of Education of Finland [116/722/2004, 134/627/2005,
   44/627/2006, 113/627/2007, 41/627/2008]; Academy of Finland [104943,
   211119, 123885]; European Commission [LSHM-CT-2004-005272]; City of
   Kuopio; Finnish Diabetes Association; Kuopio University Hospital;
   Paivikki and Sakari Sohlberg Foundation; Social Insurance Institution of
   Finland; Finnish Medical Foundation; Swedish Council for Working Life;
   Finnish Heart Association; Bruno Krachler
FX The DR's EXTRA study was supported by grants from the Ministry of
   Education of Finland (116/722/2004, 134/627/2005, 44/627/2006,
   113/627/2007, 41/627/2008), the Academy of Finland (104943, 211119,
   123885), the European Commission FP6 Integrated Project (EXEGENESIS):
   LSHM-CT-2004-005272, the City of Kuopio, the Finnish Diabetes
   Association, the Finnish Heart Association, Kuopio University Hospital,
   Paivikki and Sakari Sohlberg Foundation and the Social Insurance
   Institution of Finland. KS was supported by a grant from the Finnish
   Medical Foundation; BK was supported by grants from Bruno Krachler and
   the Swedish Council for Working Life
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NR 24
TC 38
Z9 38
U1 0
U2 7
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0307-0565
EI 1476-5497
J9 INT J OBESITY
JI Int. J. Obes.
PD AUG
PY 2012
VL 36
IS 8
BP 1135
EP 1140
DI 10.1038/ijo.2011.212
PG 6
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 990KK
UT WOS:000307629500018
PM 22105518
DA 2025-06-11
ER

PT J
AU Pushpass, RAG
   Alzoufairi, S
   Mancini, A
   Quilter, K
   Fava, F
   Delaiti, S
   Vrhovsek, U
   Christensen, C
   Joyce, SA
   Tuohy, KM
   Jackson, KG
   Lovegrove, JA
AF Pushpass, Rose -Anna Grace
   Alzoufairi, Shouq
   Mancini, Andrea
   Quilter, Karena
   Fava, Francesca
   Delaiti, Simone
   Vrhovsek, Urska
   Christensen, Camilla
   Joyce, Susan A.
   Tuohy, Kieran M.
   Jackson, Kim G.
   Lovegrove, Julie A.
TI Chronic consumption of probiotics, oats, and apples has differential
   effects on postprandial bile acid profile and cardiometabolic disease
   risk markers compared with an isocaloric control (cornflakes): a
   randomized trial
SO AMERICAN JOURNAL OF CLINICAL NUTRITION
LA English
DT Article
DE Renetta Canada Apples; probiotic; fiber; polyphenols; gut microbiota;
   apolipoprotein B; bile acids; glucose; insulin
ID CORONARY-HEART-DISEASE; REUTERI NCIMB 30242; REGULAR CONSUMPTION; STEROL
   ABSORPTION; UNSATURATED FATS; OXIDATIVE STRESS; LDL CHOLESTEROL; LIPID
   PROFILES; BLOOD-GLUCOSE; PLASMA-LIPIDS
AB Background: Dietary components that impact the gut microbiota may beneficially affect cardiometabolic health, possibly by altered bile acid meta-bolism. However, impacts of these foods on postprandial bile acids, gut microbiota, and cardiometabolic risk markers are unclear.Objectives: The aim of this study was to determine the chronic effects of probiotics, oats, and apples on postprandial bile acids, gut microbiota, and cardiometabolic health biomarkers.Methods: Using an acute within chronic parallel design, 61 volunteers (mean +/- SD: age 52 +/- 12 y; BMI 24.8 +/- 3.4 kg/m2) were randomly assigned to consume 40 g cornflakes (control), 40 g oats or 2 Renetta Canada apples each with 2 placebo capsules per day or 40 g cornflakes with 2 Lactobacillus reuteri capsules (>5 x 109 CFU) per day, for 8 wk. Fasting and postprandial serum/plasma bile acids and cardiometabolic health biomarkers, fecal bile acids, and gut microbiota composition were determined.Results: At week 0, oats and apples significantly decreased postprandial serum insulin [area under the curve (AUC): 25.6 (17.4, 33.8) and 23.4 (15.4, 31.4) vs. 42.0 (33.7, 50.2) pmol/L x min and incremental AUC (iAUC): 17.8 (11.6, 24.0) and 13.7 (7.7, 19.8) vs. 29.6 (23.3, 35.8) pmol/L x min] and C -peptide responses [AUC: 599 (514, 684) and 550 (467, 632) vs. 750 (665, 835) ng/mL x min], whereas non-esterified fatty acids were increased [AUC 135 (117, 153) vs. 86.3 (67.9, 105) and iAUC 96.2 (78.8, 114) vs. 60 (42.1, 77.9) mmol/L x min] after the apples vs. control (P < 0.05). Postprandial unconjugated [AUC: predicted means (95% CI) 1469 (1101, 1837) vs. 363 (-28, 754) mu mol/L x min and iAUC: 923 (682, 1165) vs. 22.0 (-235, 279) mu mol/L x min)] and hydrophobic [iAUC: 1210 (911, 1510) vs. 487 (168, 806) mu mol/L x min] bile acid responses were increased after 8 wk probiotic intervention vs. control (P < 0.049). None of the interventions modulated the gut microbiota.Conclusions: These results support beneficial effects of apples and oats on postprandial glycemia and the ability of the probiotic Lactobacillus reuteri to modulate postprandial plasma bile acid profiles compared with control (cornflakes), with no relationship evident between circulating bile acids and cardiometabolic health biomarkers.
C1 [Pushpass, Rose -Anna Grace; Alzoufairi, Shouq; Christensen, Camilla; Jackson, Kim G.; Lovegrove, Julie A.] Univ Reading, Inst Food Nutr & Hlth, Dept Food & Nutr Sci, Hugh Sinclair Unit Human Nutr, Harry Nursten Bldg, Reading, England.
   [Pushpass, Rose -Anna Grace; Alzoufairi, Shouq; Christensen, Camilla; Jackson, Kim G.; Lovegrove, Julie A.] Univ Reading, Inst Cardiovasc & Metab Res, Harry Nursten Bldg, Reading, England.
   [Mancini, Andrea; Fava, Francesca; Delaiti, Simone; Vrhovsek, Urska; Tuohy, Kieran M.] Fdn Edmund Mach, Res & Innovat Ctr, San Michele All Adige, Italy.
   [Quilter, Karena; Joyce, Susan A.] Univ Coll Cork, Biosci Inst, Sch Biochem & Cell Biol, Cork, Ireland.
   [Quilter, Karena; Joyce, Susan A.] Univ Coll Cork, APC Microbiome Ireland, Cork, Ireland.
   [Tuohy, Kieran M.] Univ Leeds, Sch Food Sci & Nutr, Leeds LS2 9JT, England.
C3 University of Reading; University of Reading; Fondazione Edmund Mach;
   University College Cork; University College Cork; University of Leeds
RP Lovegrove, JA (corresponding author), Univ Reading, Inst Food Nutr & Hlth, Dept Food & Nutr Sci, Hugh Sinclair Unit Human Nutr, Harry Nursten Bldg, Reading, England.; Lovegrove, JA (corresponding author), Univ Reading, Inst Cardiovasc & Metab Res, Harry Nursten Bldg, Reading, England.
EM j.a.lovegrove@reading.ac.uk
RI Christensen, Camilla/JXM-4105-2024; Jackson, Kim/G-7356-2016; Lovegrove,
   Julie/LRV-2592-2024; Tuohy, Kieran/G-9142-2011; Joyce, Susan
   A/ABE-2616-2020; Fava, Francesca/M-8213-2014
OI Delaiti, Simone/0000-0001-8886-0942; Tuohy, Kieran/0000-0001-6882-7192;
   Joyce, Susan A/0000-0003-4771-3123; Fava, Francesca/0000-0001-8530-2152;
   Christensen, Camilla/0000-0002-3253-124X
FU BBSRC; JPI-HDHL project CABALA_diethealth; MIPAAF [BB/P028209/1]; SFI
   Centres [ERA -Net Cofund ERA-HDHL N696295];  [31965/7303/16]; 
   [12/RC/2273- P2]; BBSRC [BB/P028209/1] Funding Source: UKRI
FX Supported by the BBSRC (grant number: BB/P028209/1) in conjunction with
   the JPI-HDHL project CABALA_diet & health
   (https://eventi.fmach.it/CABALA; ERA -Net Cofund ERA-HDHL N696295) and
   MIPAAF Decree n. 31965/7303/16 of 29/12/2016. SAJ and KQ are also
   supported by SFI Centres funding (12/RC/2273- P2) to APC Microbiome
   Ireland.
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NR 84
TC 4
Z9 4
U1 6
U2 17
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0002-9165
EI 1938-3207
J9 AM J CLIN NUTR
JI Am. J. Clin. Nutr.
PD FEB
PY 2023
VL 117
IS 2
BP 252
EP 265
DI 10.1016/j.ajcnut.2022.10.013
EA FEB 2023
PG 14
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 9W2WS
UT WOS:000948940800001
PM 36811563
OA Bronze, Green Published, Green Accepted
DA 2025-06-11
ER

PT J
AU Ungvari, Z
   Kunutsor, SK
AF Ungvari, Zoltan
   Kunutsor, Setor K.
TI Coffee consumption and cardiometabolic health: a comprehensive review of
   the evidence
SO GEROSCIENCE
LA English
DT Review
DE Coffee consumption; Caffeine; Cardiometabolic; Type 2 diabetes;
   Hypertension; Chronic kidney disease; Cardiovascular disease; Mortality
ID DOSE-RESPONSE METAANALYSIS; CORONARY-HEART-DISEASE; FATTY LIVER-DISEASE;
   GASTRIC-INHIBITORY POLYPEPTIDE; VASCULAR OXIDATIVE STRESS; TYPE-2
   DIABETES-MELLITUS; CHRONIC KIDNEY-DISEASE; BONE-MINERAL DENSITY; KAPPA-B
   ACTIVATION; LIFE-STYLE FACTORS
AB This review provides a comprehensive synthesis of longitudinal observational and interventional studies on the cardiometabolic effects of coffee consumption. It explores biological mechanisms, and clinical and policy implications, and highlights gaps in the evidence while suggesting future research directions. It also reviews evidence on the causal relationships between coffee consumption and cardiometabolic outcomes from Mendelian randomization (MR) studies. Findings indicate that while coffee may cause short-term increases in blood pressure, it does not contribute to long-term hypertension risk. There is limited evidence indicating that coffee intake might reduce the risk of metabolic syndrome and non-alcoholic fatty liver disease. Furthermore, coffee consumption is consistently linked with reduced risks of type 2 diabetes (T2D) and chronic kidney disease (CKD), showing dose-response relationships. The relationship between coffee and cardiovascular disease is complex, showing potential stroke prevention benefits but ambiguous effects on coronary heart disease. Moderate coffee consumption, typically ranging from 1 to 5 cups per day, is linked to a reduced risk of heart failure, while its impact on atrial fibrillation remains inconclusive. Furthermore, coffee consumption is associated with a lower risk of all-cause mortality, following a U-shaped pattern, with the largest risk reduction observed at moderate consumption levels. Except for T2D and CKD, MR studies do not robustly support a causal link between coffee consumption and adverse cardiometabolic outcomes. The potential beneficial effects of coffee on cardiometabolic health are consistent across age, sex, geographical regions, and coffee subtypes and are multi-dimensional, involving antioxidative, anti-inflammatory, lipid-modulating, insulin-sensitizing, and thermogenic effects. Based on its beneficial effects on cardiometabolic health and fundamental biological processes involved in aging, moderate coffee consumption has the potential to contribute to extending the healthspan and increasing longevity. The findings underscore the need for future research to understand the underlying mechanisms and refine health recommendations regarding coffee consumption.
C1 [Ungvari, Zoltan] Univ Oklahoma, Dept Neurosurg, Neurodegenerat & Hlth Brain Aging Program, Vasc Cognit Impairment,Hlth Sci Ctr, Oklahoma City, OK USA.
   [Ungvari, Zoltan] Univ Oklahoma, Stephenson Canc Ctr, Oklahoma City, OK USA.
   [Ungvari, Zoltan] Univ Oklahoma, Hlth Sci Ctr, Oklahoma Ctr Gerosci & Hlth Brain Aging, Oklahoma City, OK USA.
   [Ungvari, Zoltan] Univ Oklahoma, Hlth Sci Ctr, Coll Publ Hlth, Dept Hlth Promot Sci, Oklahoma City, OK USA.
   [Ungvari, Zoltan] Semmelweis Univ, Doctoral Coll, Dept Prevent Med & Publ Hlth, Int Training Program Gerosci, Budapest, Hungary.
   [Kunutsor, Setor K.] Univ Leicester, Leicester Gen Hosp, Diabet Res Ctr, Leicester Real World Evidence Unit, Gwendolen Rd, Leicester LE5 4WP, England.
   [Kunutsor, Setor K.] Univ Manitoba, St Boniface Hosp, Rady Fac Hlth Sci, Dept Internal Med, Winnipeg, MB R2H 2A6, Canada.
C3 University of Oklahoma System; University of Oklahoma Health Sciences
   Center; University of Oklahoma System; University of Oklahoma Health
   Sciences Center; University of Oklahoma System; University of Oklahoma
   Health Sciences Center; University of Oklahoma System; University of
   Oklahoma Health Sciences Center; Semmelweis University; University of
   Leicester; University Hospitals of Leicester NHS Trust; Leicester
   General Hospital; University of Manitoba; Saint Boniface Hospital;
   Children's Hospital Research Institute of Manitoba
RP Kunutsor, SK (corresponding author), Univ Leicester, Leicester Gen Hosp, Diabet Res Ctr, Leicester Real World Evidence Unit, Gwendolen Rd, Leicester LE5 4WP, England.; Kunutsor, SK (corresponding author), Univ Manitoba, St Boniface Hosp, Rady Fac Hlth Sci, Dept Internal Med, Winnipeg, MB R2H 2A6, Canada.
EM skk31@cantab.net
RI Ungvari, Zoltan/GZK-8127-2022; Kunutsor, Setor/H-9807-2019
OI KUNUTSOR, SETOR/0000-0002-2625-0273
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NR 285
TC 13
Z9 13
U1 7
U2 17
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 2509-2715
EI 2509-2723
J9 GEROSCIENCE
JI GeroScience
PD DEC
PY 2024
VL 46
IS 6
SI SI
BP 6473
EP 6510
DI 10.1007/s11357-024-01262-5
EA JUL 2024
PG 38
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA J5Y0T
UT WOS:001262207400001
PM 38963648
OA hybrid
DA 2025-06-11
ER

PT J
AU Kienes, HF
   Egert, S
AF Kienes, Hannah F.
   Egert, Sarah
TI A Systematic Review of the Impact of Fat Quantity and Fatty Acid
   Composition on Postprandial Vascular Function in Healthy Adults and
   Patients at Risk of Cardiovascular Disease
SO CURRENT DEVELOPMENTS IN NUTRITION
LA English
DT Review
DE fat quantity; SFA; MUFA; PUFA; CVD; postprandial; vascular function;
   FMD; PWV; AIx
ID ENDOTHELIAL FUNCTION; ARTERIAL STIFFNESS; OXIDATIVE STRESS;
   BRACHIAL-ARTERY; BLOOD-PRESSURE; AUGMENTATION INDEX; SATURATED FAT;
   OLIVE OIL; MEAL; DIETARY
AB Atherosclerosis is a key risk factor for developing cardiovascular diseases (CVDs). Flow-mediated dilation (FMD), which reflects vascular reactivity, as well as pulse wave velocity (PWV) and augmentation index (AIx), both markers of arterial stiffness, have emerged as noninvasive, subclinical atherosclerotic markers for the early stages of altered vascular function. In addition to the long-term effects of diet, postprandial processes have been identified as important determinants of CVD risk, and evidence suggests an acute effect of fat quantity and fatty acid (FA) composition on vascular function. However, robust analyses of this association are lacking, especially concerning parameters of arterial stiffness. Therefore, we carried out a systematic literature search in PubMed, Scopus, and the Cochrane Library to investigate the impact of fat quantity and FA composition of meals on postprandial vascular function. Postprandial studies measuring FMD, PWV, and/or AIx in healthy adults and subjects with increased CVD risk (e.g., those with hypercholesterolemia or metabolic syndrome) were analyzed. In total, 24 articles were included; 9 studies focused on the effect of high-fat meals compared with control; and 15 studies investigated the effects of different fat sources. We found that consumption of a high-fat meal causes a reduction in FMD (decrease in vasodilation) and AIx (decrease in arterial stiffness). For eicosapentaenoic acid/docosahexaenoic acid (from fish oil), postprandial assessment (FMD and AIx) indicates a beneficial effect on vascular function. There is limited evidence of an influence of CVD risk on the vascular response to meals with varying fat doses or FA composition. However, meaningful conclusions were difficult to draw because of the large heterogeneity of the studies. Inconsistent results regarding both the impact of fat dose and FA composition on postprandial vascular function should be noted. We propose standardized methods for postprandial protocols to improve data quality in future studies. This review was registered in PROSPERO as CRD42022352986.
C1 [Kienes, Hannah F.; Egert, Sarah] Univ Bonn, Inst Nutr & Food Sci, Nutr Physiol, Bonn, Germany.
C3 University of Bonn
RP Egert, S (corresponding author), Univ Bonn, Inst Nutr & Food Sci, Nutr Physiol, Bonn, Germany.
EM s.egert@uni-bonn.de
FU University of Bonn
FX This work was supported by the Open Access Publication Fund of the
   University of Bonn.
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NR 71
TC 1
Z9 1
U1 1
U2 3
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 2475-2991
J9 CURR DEV NUTR
JI Curr. Dev. Nutr.
PD DEC
PY 2023
VL 7
IS 12
AR 102025
DI 10.1016/j.cdnut.2023.102025
EA NOV 2023
PG 22
WC Nutrition & Dietetics
WE Emerging Sources Citation Index (ESCI)
SC Nutrition & Dietetics
GA CL0O4
UT WOS:001125291700001
PM 38076399
DA 2025-06-11
ER

PT J
AU Wang, XH
   Wu, WH
   Zheng, WR
   Fang, XX
   Chen, LY
   Rink, L
   Min, JX
   Wang, FD
AF Wang, Xinhui
   Wu, Wenhui
   Zheng, Wanru
   Fang, Xuexian
   Chen, Liyun
   Rink, Lothar
   Min, Junxia
   Wang, Fudi
TI Zinc supplementation improves glycemic control for diabetes prevention
   and management: a systematic review and meta-analysis of randomized
   controlled trials
SO AMERICAN JOURNAL OF CLINICAL NUTRITION
LA English
DT Review
DE zinc supplementation; glycemic control; type 2 diabetes; prediabetes;
   obesity; meta-analysis
ID C-REACTIVE PROTEIN; INSULIN-RESISTANCE; DOUBLE-BLIND; METABOLIC
   SYNDROME; MINERAL SUPPLEMENTATION; OXIDATIVE STRESS; LIPID PROFILES;
   GLUCOSE; MARKERS; RISK
AB Background: Although many studies have shown that low zinc status is associated with diabetes, the putative effects of zinc supplementation on glycemic control are inconclusive.
   Objectives: The aim of this meta-analysis of randomized controlled trials was to assess the effects of zinc supplementation in preventing and managing diabetes.
   Methods: PubMed, Embase, and the Cochrane Library were searched for articles that were published through February 10, 2019 and contained estimates for the outcomes of interest. The pooled results were then analyzed with the use of a random-effects model.
   Results: Thirty-two placebo-controlled interventions were extracted from 36 publications, involving a total of 1700 participants in 14 countries. Overall, compared with their respective control groups, the subjects in the zinc-supplementation group had a statistically significant reduction in fasting glucose [FG, weighted mean difference (WMD): -14.15 mg/dL; 95% CI: -17.36, -10.93 mg/dL], 2-h postprandial glucose (WMD: -36.85 mg/dL; 95% CI: -62.05, -11.65 mg/dL), fasting insulin (WMD: -1.82 mU/L; 95% CI: -3.10, -0.54 mU/L), homeostasis model assessment for insulin resistance (WMD: -0.73; 95% CI: -1.22, -0.24), glycated hemoglobin (WMD: -0.55%; 95% CI: -0.84, -0.27%), and high-sensitivity C-reactive protein (WMD: -1.31 mg/L; 95% CI: -2.05, -0.56 mg/L) concentrations. Moreover, subgroup analyses revealed that the effects of zinc supplementation on FG are significantly influenced by diabetic status and the formulation of the zinc supplement.
   Conclusions: Our analysis revealed that several key glycemic indicators are significantly reduced by zinc supplementation, particularly the FG in subjects with diabetes and in subjects who received an inorganic zinc supplement. Together, these findings support the notion that zinc supplementation may have clinical potential as an adjunct therapy for preventing or managing diabetes.
C1 [Wang, Xinhui; Wu, Wenhui; Zheng, Wanru; Fang, Xuexian; Chen, Liyun; Min, Junxia; Wang, Fudi] Zhejiang Univ, Affiliated Hosp 1, Sch Publ Hlth, Inst Translat Med,Sch Med, Hangzhou, Zhejiang, Peoples R China.
   [Wu, Wenhui; Wang, Fudi] China Agr Univ, Beijing Adv Innovat Ctr Food Nutr & Human Hlth, Beijing, Peoples R China.
   [Rink, Lothar] Rhein Westfal TH Aachen, RWTH, Fac Med, Inst Immunol, Aachen, Germany.
C3 Zhejiang University; China Agricultural University; RWTH Aachen
   University
RP Min, JX; Wang, FD (corresponding author), Zhejiang Univ, Affiliated Hosp 1, Sch Publ Hlth, Inst Translat Med,Sch Med, Hangzhou, Zhejiang, Peoples R China.; Wang, FD (corresponding author), China Agr Univ, Beijing Adv Innovat Ctr Food Nutr & Human Hlth, Beijing, Peoples R China.
EM junxiamin@zju.edu.cn; fwang@zju.edu.cn
RI wu, wenhui/IXX-0116-2023; Fang, Xuexian/Z-4786-2019; Wang,
   Fudi/L-7888-2018; Min, Junxia/E-7622-2016; Rink, Lothar/C-1055-2014
OI Wang, Xinhui/0000-0001-7713-6262; Wang, Fudi/0000-0001-8730-0003; Min,
   Junxia/0000-0001-8099-6327; Rink, Lothar/0000-0002-5658-2893
FU National Natural Science Foundation of China [31600953, 31530034,
   31570791, 91542205]; National Key R&D Program of China [2018YFA0507801,
   2018YFA0507802]; Zhejiang Provincial Natural Science Foundation of China
   [LQ15C110002]
FX This study was supported by research grants from the National Natural
   Science Foundation of China (31600953 to XW, 31530034 to FW, 31570791
   and 91542205 to JM), the National Key R&D Program of China
   (2018YFA0507801 to JM and 2018YFA0507802 to FW), and the Zhejiang
   Provincial Natural Science Foundation of China (LQ15C110002 to XW).
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NR 82
TC 117
Z9 118
U1 3
U2 35
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0002-9165
EI 1938-3207
J9 AM J CLIN NUTR
JI Am. J. Clin. Nutr.
PD JUL
PY 2019
VL 110
IS 1
BP 76
EP 90
DI 10.1093/ajcn/nqz041
PG 15
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA IM5YP
UT WOS:000478070200012
PM 31161192
OA Bronze
DA 2025-06-11
ER

PT J
AU Jackson, K
   Dressler, N
   Ben-Shushan, RS
   Meerson, A
   LeBaron, TW
   Tamir, S
AF Jackson, Karen
   Dressler, Noa
   Ben-Shushan, Rotem S.
   Meerson, Ari
   LeBaron, Tyler W.
   Tamir, Snait
TI Effects of alkaline-electrolyzed and hydrogen-rich water, in a
   high-fat-diet nonalcoholic fatty liver disease mouse model
SO WORLD JOURNAL OF GASTROENTEROLOGY
LA English
DT Article
DE Hydrogen-rich-water; Nonalcoholic fatty liver disease; Alkaline water;
   Metabolic syndrome; Molecular hydrogen; High-fat diet
ID REDUCED WATER; MOLECULAR-HYDROGEN; OXIDATIVE STRESS; IMPROVES;
   STEATOHEPATITIS; PATHOGENESIS; ANTIOXIDANT; METABOLISM; ADIPONECTIN;
   EXPRESSION
AB AIM
   To identify the effect of hydrogen-rich water (HRW) and electrolyzed-alkaline water (EAW) on high-fat-induced non-alcoholic fatty acid disease in mice.
   METHODS
   Mice were divided into four groups: (1) Regular diet (RD)/regular water (RW); (2) high-fat diet (HFD)/RW; (3) RD/EAW; and (4) HFD/EAW. Weight and body composition were measured. After twelve weeks, animals were sacrificed, and livers were processed for histology and reverse-transcriptase polymerase chain reaction. A similar experiment was performed using HRW to determine the influence and importance of molecular hydrogen (H-2) in EAW. Finally, we compared the response of hepatocytes isolated from mice drinking HRW or RW to palmitate overload.
   RESULTS
   EAW had several properties important to the study: (1) pH = 11; (2) oxidation-reduction potential of -495 mV; and (3) H-2 = 0.2 mg/L. However, in contrast to other studies, there were no differences between the groups drinking EAW or RW in either the RD or HFD groups. We hypothesized that the null result was due to low H-2 concentrations. Therefore, we evaluated the effects of RW and low and high HRW concentrations (L-HRW = 0.3 mg H-2/L and H-HRW = 0.8 mg H-2/L, respectively) in mice fed an HFD. Compared to RW and L-HRW, H-HRW resulted in a lower increase in fat mass (46% vs 61%), an increase in lean body mass (42% vs 28%), and a decrease in hepatic lipid accumulation (P < 0.01). Lastly, exposure of hepatocytes isolated from mice drinking H-HRW to palmitate overload demonstrated a protective effect from H-2 by reducing hepatocyte lipid accumulation in comparison to mice drinking regular water.
   CONCLUSION
   H-2 is the therapeutic agent in electrolyzed-alkaline water and attenuates HFD-induced nonalcoholic fatty liver disease in mice.
C1 [Jackson, Karen; Dressler, Noa; Ben-Shushan, Rotem S.; Meerson, Ari; Tamir, Snait] MIGAL Galilee Res Inst, Lab Human Hlth & Nutr Sci, POB 831, IL-11016 Kyriat Shmona, Israel.
   [Jackson, Karen; Dressler, Noa; Tamir, Snait] Tel Hai Coll, IL-12110 Upper Galilee, Israel.
   [LeBaron, Tyler W.] Slovak Acad Sci, Inst Heart Res, Ctr Expt Med, Bratislava 84005, Slovakia.
   [LeBaron, Tyler W.] Mol Hydrogen Inst, Salt Lake City, UT 48101 USA.
C3 Tel Hai Academic College; Slovak Academy of Sciences; Centre of
   Experimental Medicine, SAS; Institute for Heart Research, SAS
RP Jackson, K (corresponding author), MIGAL Galilee Res Inst, Lab Human Hlth & Nutr Sci, POB 831, IL-11016 Kyriat Shmona, Israel.
EM karen@migal.org.il
RI LeBaron, Tyler/GLT-7071-2022; Meerson, Ari/N-2338-2019
OI LeBaron, Tyler/0000-0001-9164-6728; Meerson, Ari/0000-0002-5811-7952
FU Tel Hai College Research funding Grant [25-2-14-114]
FX Supported by Tel Hai College Research funding Grant, No. 25-2-14-114.
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NR 60
TC 28
Z9 31
U1 0
U2 22
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 8226 REGENCY DR, PLEASANTON, CA 94588 USA
SN 1007-9327
EI 2219-2840
J9 WORLD J GASTROENTERO
JI World J. Gastroenterol.
PD DEC 7
PY 2018
VL 24
IS 45
BP 5095
EP 5108
DI 10.3748/wjg.v24.i45.5095
PG 14
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA HD7UQ
UT WOS:000452759500005
PM 30568387
OA Green Submitted, Green Published, hybrid
DA 2025-06-11
ER

PT J
AU de Oliveira, DM
   Dourado, GKZS
   Cesar, TB
AF de Oliveira, David Michel
   Zanotti Simoes Dourado, Grace Kelly
   Cesar, Thais Borges
TI Hesperidin associated with continuous and interval swimming improved
   biochemical and oxidative biomarkers in rats
SO JOURNAL OF THE INTERNATIONAL SOCIETY OF SPORTS NUTRITION
LA English
DT Article
DE Hesperidin; Continuous swimming; Interval swimming; Blood serum
   biomarkers; Antioxidant; Rat
ID RESISTANCE EXERCISE; ANTIOXIDANT STATUS; METABOLIC SYNDROME; CITRUS
   FLAVONOIDS; LIPID-METABOLISM; ORANGE JUICE; CHOLESTEROL; HESPERETIN;
   SERUM; RESPONSES
AB Background: Citrus flavonoids, such as hesperidin, have shown therapeutic properties that improve hyperglycemia and insulin resistance, and decrease blood serum lipids and inflammation. The current investigation studied the effects of hesperidin supplementation associated with continuous and interval swimming on the biochemical parameters (glucose, cholesterol and triglycerides), and oxidative stress markers (TBARS and DPPH) in rats.
   Methods: The animals (n = 60) were randomly divided in six groups: negative (C) and positive control (CH) for hesperidin supplementation, and continuous or interval swimming without (CS and IS) or with hesperidin supplementation (CSH and ISH). Hesperidin was given by gavage for four weeks (100 mg/kg body mass) before the exercise. Continuous swimming was performed for 50 min with loads from 5% to 8 % of body weight from the first to fourth week, while interval swimming training was performed for 50 min in sessions of 1 min of swimming followed by 2 min of resting, carrying loads from 10% to 15, 20 and 25% from the first to fourth week. At the end of the experiment, blood serum samples were draw to perform analysis of glucose, total cholesterol, HDL-C and triglycerides. Oxidative biomarkers were evaluated by lipid peroxidation (TBARS) and antioxidant capacity assay (DPPH) of the blood serum.
   Results: There was a continuous decline of serum glucose from C (100%) > CH (97%) > CS (94%) > CSH (91%, p < .05), IS (87%, p < .05) > ISH (80%, p < .05), showing a combined beneficial effect of hesperidin and swimming. Also, continuous or intermittent swimming with hesperidin supplementation lowered total cholesterol (-16%, p < .05), LDL-C (-50%, p < 0.05) and triglycerides (-19%, p < 0.05), and increased HDL-C (48%, p < .05). Furthermore, hesperidin enhanced the antioxidant capacity on the continuous swimming group (183%, p < .05) and lowered the lipid peroxidation on the interval swimming group (-45%, p < .05).
   Conclusions: Hesperidin supplementation per se, or in combination with swimming exercise protocols, improved the biochemical profile and antioxidant biomarkers evidencing that the use of flavanones may enhance the health benefits promoted by exercise.
C1 [de Oliveira, David Michel; Zanotti Simoes Dourado, Grace Kelly; Cesar, Thais Borges] UNESP, Sch Pharmaceut Sci, Dept Food & Nutr, BR-14802901 Araraquara, Brazil.
C3 Universidade Estadual Paulista
RP Cesar, TB (corresponding author), UNESP, Sch Pharmaceut Sci, Dept Food & Nutr, Rodovia Araraquara Jau,Km 1, BR-14802901 Araraquara, Brazil.
EM tcesar@fcfar.unesp.br
RI Cesar, Thais/T-6110-2019; Cesar, Thais/I-4540-2013; Oliveira, David
   Michel/B-6838-2019
OI Cesar, Thais/0000-0001-7878-7075; Oliveira, David
   Michel/0000-0003-0658-7693
FU Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq),
   Brazil
FX We are grateful to the Conselho Nacional de Desenvolvimento Cientifico e
   Tecnologico (CNPq), Brazil, for the scholarship to Grace Dourado. We
   also thank to Hayashibara, Japan, for providing glucosyl hesperidin for
   the experiments.
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NR 54
TC 26
Z9 27
U1 0
U2 7
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1550-2783
J9 J INT SOC SPORT NUTR
JI J. Int. Soc. Sport Nutr.
PD MAY 24
PY 2013
VL 10
AR 27
DI 10.1186/1550-2783-10-27
PG 7
WC Nutrition & Dietetics; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics; Sport Sciences
GA 156CR
UT WOS:000319798700001
PM 23705637
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Gitt, AK
   Schmieder, RE
   Duetting, E
   Bramlage, P
   Schneider, S
   Tschöpe, D
AF Gitt, Anselm K.
   Schmieder, Roland E.
   Duetting, Eva
   Bramlage, Peter
   Schneider, Steffen
   Tschoepe, Diethelm
CA DIALOGUE Study Grp
TI Achievement of recommended glucose and blood pressure targets in
   patients with type 2 diabetes and hypertension in clinical practice -
   study rationale and protocol of DIALOGUE
SO CARDIOVASCULAR DIABETOLOGY
LA English
DT Article
DE Type-2 diabetes; Hypertension; Efficacy; Effectiveness; Safety;
   Vildagliptin
ID ANTIDIABETIC PHARMACOTHERAPY; MULTIFACTORIAL INTERVENTION; EUROPEAN
   GUIDELINES; METABOLIC SYNDROME; GERMAN POPULATION; OXIDATIVE STRESS;
   VASCULAR-DISEASE; HEART-FAILURE; MANAGEMENT; METFORMIN
AB Background: Patients with type 2 diabetes have 2-4 times greater risk for cardiovascular morbidity and mortality than those without, and this is even further aggravated if they also suffer from hypertension. Unfortunately, less than one third of hypertensive diabetic patients meet blood pressure targets, and more than half fail to achieve target HbA1c values. Thus, appropriate blood pressure and glucose control are of utmost importance. Since treatment sometimes fails in clinical practice while clinical trials generally suggest good efficacy, data from daily clinical practice, especially with regard to the use of newly developed anti-diabetic and anti-hypertensive compounds in unselected patient populations, are essential. The DIALOGUE registry aims to close this important gap by evaluating different treatment approaches in hypertensive type 2 diabetic patients with respect to their effectiveness and tolerability and their impact on outcomes. In addition, DIALOGUE is the first registry to determine treatment success based on the new individualized treatment targets recommended by the ADA and the EASD.
   Methods: DIALOGUE is a prospective observational German multicentre registry and will enrol 10,000 patients with both diabetes and hypertension in up to 700 sites. After a baseline visit, further documentations are scheduled at 6, 12 and 24 months. There are two co-primary objectives referring to the most recent guidelines for the treatment of diabetes and hypertension: 1) individual HbA1c goal achievement with respect to anti-diabetic pharmacotherapy and 2) individual blood pressure goal achievement with different antihypertensive treatments. Among the secondary objectives the rate of major cardio-vascular and cerebro-vascular events (MACCE) and the rate of hospitalizations are the most important.
   Conclusion: The registry will be able to gain insights into the reasons for the obvious gap between the demonstrated efficacy and safety of anti-diabetic and anti-hypertensive drugs in clinical trials and their real world balance of effectiveness and safety.
C1 [Gitt, Anselm K.; Schneider, Steffen] Stiftung Inst Herzinfarktforsch Ludwigshafen, D-67063 Ludwigshafen, Germany.
   [Gitt, Anselm K.] Herzzentrum Ludwigshafen, Med Klin B, Ludwigshafen, Germany.
   [Schmieder, Roland E.] Univ Klinikum Erlangen, Med Klin 4, Erlangen, Germany.
   [Duetting, Eva] Novartis Pharma GmbH, Nurnberg, Germany.
   [Bramlage, Peter] Inst Pharmakol & Pravent Med, Mahlow, Germany.
   [Tschoepe, Diethelm] Deutsch Diabet Stiftung, D-32545 Bad Oeynhausen, Germany.
   [Tschoepe, Diethelm] Ruhr Univ Bochum, Herz & Diabet Zentrum Nordrhein Westfalen Bad Oey, Univ Klin, Bochum, Germany.
C3 Institute Heart Attack Research; University of Erlangen Nuremberg;
   Novartis; Novartis Germany; Ruhr University Bochum
RP Gitt, AK (corresponding author), Stiftung Inst Herzinfarktforsch Ludwigshafen, Bremser Str 79, D-67063 Ludwigshafen, Germany.
EM gitta@klilu.de
RI Gitt, Anselm/JNE-0672-2023
OI Bramlage, Peter/0000-0003-4970-2110
FU Novartis Pharma GmbH, Numberg, Germany
FX Novartis Pharma GmbH, Numberg, Germany funded this registry.
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NR 45
TC 4
Z9 4
U1 0
U2 7
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1475-2840
J9 CARDIOVASC DIABETOL
JI Cardiovasc. Diabetol.
PD DEC 5
PY 2012
VL 11
AR 148
DI 10.1186/1475-2840-11-148
PG 8
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism
GA 076EP
UT WOS:000313939600001
PM 23216660
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Schloms, L
   Storbeck, KH
   Swart, P
   Gelderblom, WCA
   Swart, AC
AF Schloms, Lindie
   Storbeck, Karl-Heinz
   Swart, Pieter
   Gelderblom, Wentzel C. A.
   Swart, Amanda C.
TI The influence of Aspalathus linearis (Rooibos) and
   dihydrochalcones on adrenal steroidogenesis: Quantification of steroid
   intermediates and end products in H295R cells
SO JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
LA English
DT Article
DE Adrenal steroidogenesis; H295R; Cortisol; Rooibos; Flavonoids;
   UPLC-MS/MS
ID AFRICAN HERBAL TEAS; HONEYBUSH CYCLOPIA-INTERMEDIA; ALDOSTERONE
   SYNTHASE; CORTISOL PRODUCTION; GUINEA-PIG; BLACK TEA; BIOSYNTHESIS;
   INHIBITION; FLAVONOIDS; GENISTEIN
AB The steroid hormone output of the adrenal gland is crucial in the maintenance of hormonal homeostasis, with hormonal imbalances being associated with numerous clinical conditions which include, amongst others, hypertension, metabolic syndrome, cardiovascular disease, insulin resistance and type 2 diabetes. Aspalathus linearis (Rooibos), which has been reported to aid stress-related symptoms linked to metabolic diseases, contains a wide spectrum of bioactive phenolic compounds of which aspalathin is unique. In this study the inhibitory effects of Rooibos and the dihydrochalcones, aspalathin and nothofagin, were investigated on adrenal steroidogenesis. The activities of both cytochrome P450 17 alpha-hydroxylase/17,20 lyase and cytochrome P450 21-hydroxylase were significantly inhibited in COS-1 cells. In order to study the effect of these compounds in H295R cells, a human adrenal carcinoma cell line, a novel UPLC-MS/MS method was developed for the detection and quantification of twenty-one steroid metabolites using a single chromatographic separation. Under both basal and forskolin-stimulated conditions, the total amount of steroids produced in H295R cells significantly decreased in the presence of Rooibos, aspalathin and nothofagin. Under stimulated conditions, Rooibos decreased the total steroid output 4-fold and resulted in a significant reduction of aldosterone and cortisol precursors. Dehydroepiandrosterone-sulfate levels were unchanged, while the levels of androstenedione (A4) and 11 beta-hydroxyandrostenedione (11 beta OH-A4) were inhibited 5.5 and 2.3-fold, respectively. Quantification of 11 beta OH-A4 showed this metabolite to be a major product of steroidogenesis in H295R cells and we confirm, for the first time, that this steroid metabolite is the product of the hydroxylation of A4 by human cytochrome P450 11 beta-hydroxylase. Taken together our results demonstrate that Rooibos, aspalathin and nothofagin influence steroid hormone biosynthesis and the flux through the mineralocorticoid, glucocorticoid and androgen pathways, thus possibly contributing to the alleviation of negative effects arising from elevated glucocorticoid levels. (C) 2011 Elsevier Ltd. All rights reserved.
C1 [Schloms, Lindie; Storbeck, Karl-Heinz; Swart, Pieter; Gelderblom, Wentzel C. A.; Swart, Amanda C.] Univ Stellenbosch, Dept Biochem, ZA-7600 Stellenbosch, South Africa.
   [Gelderblom, Wentzel C. A.] MRC, PROMEC Unit, ZA-7505 Tygerberg, South Africa.
C3 Stellenbosch University
RP Swart, AC (corresponding author), Univ Stellenbosch, Dept Biochem, Private Bag X1, ZA-7602 Matieland, South Africa.
EM acswart@sun.ac.za
RI Storbeck, Karl/AAF-5126-2020; Swart, Amanda C./O-5939-2017; Swart,
   Pieter/J-3856-2015
OI Swart, Amanda C./0000-0001-7529-8989; Storbeck,
   Karl-Heinz/0000-0003-1669-6383; Swart, Pieter/0000-0001-8610-4799
FU South African Rooibos Council; Medical Research Council of South Africa;
   Harry Crossley foundation
FX The authors wish to acknowledge the financial support of the South
   African Rooibos Council, the Medical Research Council of South Africa
   and the Harry Crossley foundation. The authors would also like to thank
   Patricia Storbeck for her assistance with the preparation of this
   manuscript as well as Dr. Marietjie Stander and Ms. Denise Hough for
   technical advice. The H295R cell line was a kind gift from William E.
   Rainey.
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NR 58
TC 75
Z9 77
U1 1
U2 21
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0960-0760
J9 J STEROID BIOCHEM
JI J. Steroid Biochem. Mol. Biol.
PD FEB
PY 2012
VL 128
IS 3-5
BP 128
EP 138
DI 10.1016/j.jsbmb.2011.11.003
PG 11
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 901LY
UT WOS:000300969600006
PM 22101210
DA 2025-06-11
ER

PT J
AU Ioachimescu, AG
   Brennan, DM
   Hoar, BM
   Hazen, SL
   Hoogwerf, BJ
AF Ioachimescu, Adriana G.
   Brennan, Danielle M.
   Hoar, Brian M.
   Hazen, Stanley L.
   Hoogwerf, Byron J.
TI Serum uric acid is an independent predictor of all-cause mortality in
   patients at high risk of cardiovascular disease
SO ARTHRITIS AND RHEUMATISM
LA English
DT Article
ID CORONARY-HEART-DISEASE; SYSTOLIC HYPERTENSION; EVENTS; DEATH;
   HYPERURICEMIA; CREATININE; OXIDATION; OUTCOMES; PROTEIN; IMPACT
AB Objective. Uric acid is a product of the activity of xanthine oxidase, an enzyme linked to oxidative stress, endothelial dysfunction, and heart failure. It is unclear whether adding uric acid levels to the assessment of cardiovascular risk might contribute to the improved ability to stratify cardiovascular risk. The purpose of this study was to evaluate the prognostic value of serum uric acid levels in a large cohort of men and women at high risk of cardiovascular disease.
   Methods. Serum uric acid levels were determined in all patients seen for primary/secondary cardiovascular disease prevention at the Cleveland Clinic Section of Preventive Cardiology and Rehabilitation between 1998 and 2004, and all data were entered into the Preventive Cardiology Information System (PreCIS) database. Vital status of the patients was determined through the Social Security Death Index. Death from all causes was summarized across quartiles of uric acid values.
   Results. A total of 3,098 patients (age range 18-87 years) were identified in the database, among whom 43% had cardiovascular disease. There were 156 deaths (5%) during the 14,262 person-years of followup. For each 1-mg/dl increase in the serum uric acid level, there was a 39% increase in the risk of death (by Cox regression analysis). After adjusting for age, sex, smoking status, alcohol consumption, weight, body mass index, waist circumference, blood pressure, history of cardiovascular disease, estimated glomerular filtration rate, levels of cholesterol fractions, and plasma glucose levels, the serum uric acid level continued to predict the risk of death (hazard ratio = 1.26 [95% confidence interval 1.15-1.38], P < 0.001). This association was present regardless of diuretic use. Concordance index (C statistic) analyses showed that uric acid significantly improved the predictive accuracy of a model that included Framingham Heart Study score factors, metabolic syndrome components, and fibrinogen levels.
   Conclusion. Serum uric acid levels are an independent predictor of death in patients at high risk of cardiovascular disease. Further studies are warranted to evaluate its prognostic implications and potential utility in the monitoring of therapy.
C1 [Ioachimescu, Adriana G.; Brennan, Danielle M.; Hoar, Brian M.; Hazen, Stanley L.; Hoogwerf, Byron J.] Cleveland Clin, Dept Diabet Endocrinol & Metab, Cleveland, OH 44195 USA.
C3 Cleveland Clinic Foundation
RP Hoogwerf, BJ (corresponding author), Cleveland Clin, Dept Diabet Endocrinol & Metab, 9500 Euclid Ave, Cleveland, OH 44195 USA.
EM hoogweb@ccf.org
RI Elgar, Frank/ABE-7450-2020; Hazen, Stanley/ABD-5845-2021; Ioachimescu,
   Adriana/V-8070-2019
FU NHLBI NIH HHS [P01-HL-076491] Funding Source: Medline
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NR 35
TC 159
Z9 174
U1 0
U2 12
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0004-3591
EI 1529-0131
J9 ARTHRITIS RHEUM-US
JI Arthritis Rheum.
PD FEB
PY 2008
VL 58
IS 2
BP 623
EP 630
DI 10.1002/art.23121
PG 8
WC Rheumatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Rheumatology
GA 264BR
UT WOS:000253260700035
PM 18240236
OA Bronze
DA 2025-06-11
ER

PT J
AU Si, SA
   Chen, MQ
   Zhang, GJ
AF Si, Shang-An
   Chen, Meng-Qi
   Zhang, Gui-Ju
TI Association of serum uric acid with hypertriglyceridemia in children and
   adolescents: a cross-sectional study
SO LIPIDS IN HEALTH AND DISEASE
LA English
DT Article
DE Serum uric acid; Hypertriglyceridemia; NHANES; Children; Adolescent
ID ENDOTHELIAL DYSFUNCTION; METABOLIC SYNDROME; HYPERURICEMIA; GENERATION;
   PREVALENCE; OBESITY; STRESS; LEVEL; RISK; FAT
AB Background Uric acid (UA), a liver-derived metabolite, is intimately tied to metabolic disorders. Although ample research underscores its connection with hypertriglyceridemia (HTG), studies focusing on adolescents remain limited. To fill the gaps in epidemiology,this study focused on analyzing the relationship between the levels of uric acid and HTG in a demographic sample comprising adolescents from the United States. Methods In this study, a total of 4,435 participants through the National Health and Nutrition Examination Survey (NHANES) from 2011 to 2020. The exposure variable was serum uric acid (SUA), the effect variable was HTG, and the covariates included demographic, questionnaire, physical examination and laboratory indicators. We utilized weighted logistic regression and meticulous subgroup evaluations to discern the intrinsic link between SUA and HTG. Stratified analyses augmented the validation of this association, while smooth curve fitting probed for potential nonlinear correlations. Results The study included 4,435 participants. Male adolescents exhibit elevated SUA levels. After adjusting for all variables, the weighted multiple logistic regression model revealed that SUA was positively correlated with HTG risk (OR = 1.006, 95% CI: 1.005-1.007). This relationship was consistent across the three tertiles group of SUA (T1: OR = 1.006 [95% CI: 1.005-1.007]; T2: OR = 1.006 [95% CI: 1.005-1.007]; T3: OR = 1.004 [95% CI: 1.003-1.006]; P for trend < 0.001). Stratified analyses confirmed that the positive correlation between SUA and HTG risk was significant, irrespective of sex, age or race. Conclusions In American children and adolescents aged 12 to 18 years, there was a pronounced association between SUA and HTG. SUA could serve as a risk indicator for HTG. It is recommended that children diagnosed with HTG should be regularly tested for SUA levels. In addition, it is recommended that SUA be included in the comprehensive care of children diagnosed with HTG.
C1 [Si, Shang-An; Chen, Meng-Qi; Zhang, Gui-Ju] Shandong Univ Tradit Chinese Med, Clin Med Coll 1, Shandong 250014, Peoples R China.
   [Zhang, Gui-Ju] Shandong Univ Tradit Chinese Med, Affiliated Hosp, Shandong 250014, Peoples R China.
C3 Shandong University of Traditional Chinese Medicine; Shandong University
   of Traditional Chinese Medicine
RP Zhang, GJ (corresponding author), Shandong Univ Tradit Chinese Med, Clin Med Coll 1, Shandong 250014, Peoples R China.; Zhang, GJ (corresponding author), Shandong Univ Tradit Chinese Med, Affiliated Hosp, Shandong 250014, Peoples R China.
EM 60170068@sdutcm.edu.cn
RI Zhang, Guiju/GNP-0911-2022
FU Shandong focused on Research and Development Projects [2019GSF108157]
FX This work was supported by Shandong focused on Research and Development
   Projects (project number: 2019GSF108157).
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NR 53
TC 2
Z9 2
U1 5
U2 7
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1476-511X
J9 LIPIDS HEALTH DIS
JI Lipids Health Dis.
PD JUN 24
PY 2024
VL 23
IS 1
AR 195
DI 10.1186/s12944-024-02182-1
PG 10
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA WE7H3
UT WOS:001253253200001
PM 38915087
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Lopez-Escalera, S
   Lund, ML
   Hermes, GDA
   Choi, BSY
   Sakamoto, K
   Wellejus, A
AF Lopez-Escalera, Silvia
   Lund, Mari L. L.
   Hermes, Gerben D. A.
   Choi, Beatrice S. -Y.
   Sakamoto, Kei
   Wellejus, Anja
TI In Vitro Screening for Probiotic Properties of Lactobacillus and
   Bifidobacterium Strains in Assays Relevant for Non-Alcoholic
   Fatty Liver Disease Prevention
SO NUTRIENTS
LA English
DT Article
DE probiotics; lactobacillus; bifidobacterium; NAFLD; gut health; GLP-1;
   intestinal organoids; microbial metabolomics; bacteria-host interaction;
   de novo lipogenesis
ID GUT MICROBIAL METABOLITES; ARYL-HYDROCARBON RECEPTOR; INTESTINAL
   PERMEABILITY; PEPTIDE-1 SECRETION; RHAMNOSUS GG; ACIDS; PHYSIOLOGY;
   HEALTH; INDOLE; INTERPLAY
AB Non-alcoholic fatty liver disease (NAFLD) is a multifactorial metabolic disorder that poses health challenges worldwide and is expected to continue to rise dramatically. NAFLD is associated with metabolic syndrome, type 2 diabetes mellitus, and impaired gut health. Increased gut permeability, caused by disturbance of tight junction proteins, allows passage of damaging microbial components that, upon reaching the liver, have been proposed to trigger the release of inflammatory cytokines and generate cellular stress. A growing body of research has suggested the utilization of targeted probiotic supplements as a preventive therapy to improve gut barrier function and tight junctions. Furthermore, specific microbial interactions and metabolites induce the secretion of hormones such as GLP-1, resulting in beneficial effects on liver health. To increase the likelihood of finding beneficial probiotic strains, we set up a novel screening platform consisting of multiple in vitro and ex vivo assays for the screening of 42 bacterial strains. Analysis of transepithelial electrical resistance response via co-incubation of the 42 bacterial strains with human colonic cells (Caco-2) revealed improved barrier integrity. Then, strain-individual metabolome profiling was performed revealing species-specific clusters. GLP-1 secretion assay with intestinal secretin tumor cell line (STC-1) found at least seven of the strains tested capable of enhancing GLP-1 secretion in vitro. Gene expression profiling in human biopsy-derived intestinal organoids was performed using next generation sequencing transcriptomics post bacterial co-incubation. Here, different degrees of immunomodulation by the increase in certain cytokine and chemokine transcripts were found. Treatment of mouse primary hepatocytes with selected highly produced bacterial metabolites revealed that indole metabolites robustly inhibited de novo lipogenesis. Collectively, through our comprehensive bacterial screening pipeline, not previously ascribed strains from both Lactobacillus and Bifidobacterium genera were proposed as potential probiotics based on their ability to increase epithelial barrier integrity and immunity, promote GLP-1 secretion, and produce metabolites relevant to liver health.
C1 [Lopez-Escalera, Silvia; Lund, Mari L. L.; Hermes, Gerben D. A.; Wellejus, Anja] Chr Hansen AS, Human Hlth Res, Sci Affairs, Boge 10-12, DK-2970 Horsholm, Denmark.
   [Lopez-Escalera, Silvia] Friedrich Schiller Univ Jena, Fak Biowissensch, Bachstr 18K, D-07743 Jena, Germany.
   [Choi, Beatrice S. -Y.] Univ Copenhagen, Fac Hlth & Med Sci, Dept Biomed Sci, DK-2200 Copenhagen, Denmark.
   [Sakamoto, Kei] Univ Copenhagen, Novo Nordisk Fdn, Ctr Basic Metab Res, DK-2200 Copenhagen, Denmark.
C3 Chr Hansen; Friedrich Schiller University of Jena; University of
   Copenhagen; Novo Nordisk Foundation; University of Copenhagen
RP Wellejus, A (corresponding author), Chr Hansen AS, Human Hlth Res, Sci Affairs, Boge 10-12, DK-2970 Horsholm, Denmark.
EM dkawe@chr-hansen.com
RI Hermes, Gerben/S-9661-2019; Sakamoto, Kei/HJB-0815-2022; Choi,
   Beatrice/GZK-9348-2022; Sakamoto, Kei/C-8806-2019
OI Wellejus, Anja/0000-0003-4350-6063; Lund, Mari
   Lilith/0000-0003-0811-5040; Lopez-Escalera, Silvia/0000-0002-0546-4926;
   Sakamoto, Kei/0000-0001-8839-5980; Hermes, Gerben D.
   A./0000-0003-4314-9553; Choi, Beatrice/0000-0001-8160-9448
FU European Union [813781]; Novo Nordisk Foundation Center for Basic
   Metabolic Research; Novo Nordisk Foundation [NNF18CC0034900]; Marie
   Curie Actions (MSCA) [813781] Funding Source: Marie Curie Actions (MSCA)
FX This project has received funding from the European Union's Horizon 2020
   research and innovation program under Marie Sklodowska-Curie grant
   agreement number 813781. The Novo Nordisk Foundation Center for Basic
   Metabolic Research is an independent research center based at the
   University of Copenhagen, Denmark, and partially funded by an
   unconditional donation from the Novo Nordisk Foundation (grant number
   NNF18CC0034900).
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NR 104
TC 11
Z9 12
U1 3
U2 24
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD MAY 18
PY 2023
VL 15
IS 10
AR 2361
DI 10.3390/nu15102361
PG 23
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA H7HO1
UT WOS:000997632200001
PM 37242245
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Tenorio-Mucha, J
   Busta-Flores, P
   Lazo-Porras, M
   Vetter, B
   Safary, E
   Moran, AE
   Gupta, R
   Bernabé-Ortiz, A
AF Tenorio-Mucha, Janeth
   Busta-Flores, Patricia
   Lazo-Porras, Maria
   Vetter, Beatrice
   Safary, Elvis
   Moran, Andrew E.
   Gupta, Reena
   Bernabe-Ortiz, Antonio
TI Facilitators and barriers of the implementation of point-of-care devices
   for cardiometabolic diseases: a scoping review
SO BMC HEALTH SERVICES RESEARCH
LA English
DT Review
DE Point-of-care testing; Noncommunicable diseases; Chronic disease;
   Metabolic syndrome; Implementation science
ID DIAGNOSIS; TESTS; CHALLENGES
AB BackgroundPoint-of-care testing (POCT) devices may facilitate the delivery of rapid and timely results, providing a clinically important advantage in patient management. The challenges and constraints in the implementation process, considering different levels of actors have not been much explored. This scoping review aimed to assess literature pertaining to implementation facilitators and barriers of POCT devices for the diagnosis or monitoring of cardiometabolic diseases.MethodsA scoping review of the literature was conducted. The inclusion criteria were studies on the inception, planning, or implementation of interventions with POCT devices for the diagnosis or monitoring of cardiometabolic diseases defined as dyslipidemia, cardiovascular diseases, type 2 diabetes, and chronic kidney disease. We searched MEDLINE, Embase, and Global Health databases using the OVID searching engine until May 2022. The Consolidated Framework of Implementation Research (CFIR) was used to classify implementation barriers and facilitators in five constructs. Also, patient, healthcare professional (HCP), and organization level was used.ResultsTwenty studies met the eligibility criteria for data extraction. All studies except two were conducted in high-income countries. Some findings are: 1) Intervention: the most widely recognized facilitator was the quick turnaround time with which results are obtained. 2) Outer setting: at the organizational level, the lack of clear regulatory and accreditation mechanisms has hindered the adoption and sustainability of the use of POCT. 3) Inner setting: for HCP, performing POCT during the consultation was both a facilitator and a barrier in terms of time, personnel, and service delivery. 4) Individuals: the implementation of POCT may generate stress and discomfort in some HCP in terms of training and new responsibilities. 5) Process: for patients, it is highly appreciated that obtaining the sample was simple and more comfortable if venipuncture was not used.ConclusionThis scoping review has described the facilitators and barriers of implementing a POCT device for cardiometabolic conditions using the CFIR. The information can be used to design better strategies to implement these devices and benefit more populations that have low access to cardiometabolic tests.
C1 [Tenorio-Mucha, Janeth; Lazo-Porras, Maria; Bernabe-Ortiz, Antonio] Univ Peruana Cayetano Heredia, CRONICAS Ctr Excellence Chron Dis, Ave Armendariz 445 Miraflores, Lima, Peru.
   [Busta-Flores, Patricia] Univ Peruana Cayetano Heredia, Fac Med Alberto Hurtado, CONEVID Unidad Conocimiento & Evidencia, Lima, Peru.
   [Vetter, Beatrice; Safary, Elvis] FIND, Geneva, Switzerland.
   [Moran, Andrew E.; Gupta, Reena] Resolve Save Lives, New York, NY USA.
   [Gupta, Reena] Univ Calif San Francisco, Dept Med Med, San Francisco, CA USA.
C3 Universidad Peruana Cayetano Heredia; Universidad Peruana Cayetano
   Heredia; Foundation For Innovative New Diagnostics; University of
   California System; University of California San Francisco
RP Bernabé-Ortiz, A (corresponding author), Univ Peruana Cayetano Heredia, CRONICAS Ctr Excellence Chron Dis, Ave Armendariz 445 Miraflores, Lima, Peru.
RI Tenorio-Mucha, Janeth/LXA-5911-2024; Benet, Mikhail/AAS-2086-2020
OI Tenorio-Mucha, Janeth/0000-0003-2837-5149; Gupta,
   Reena/0009-0004-7116-7278; BUSTA FLORES, PATRICIA
   JANET/0000-0003-2470-3520
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NR 53
TC 10
Z9 10
U1 2
U2 8
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1472-6963
J9 BMC HEALTH SERV RES
JI BMC Health Serv. Res.
PD APR 28
PY 2023
VL 23
IS 1
AR 412
DI 10.1186/s12913-023-09419-2
PG 11
WC Health Care Sciences & Services
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Health Care Sciences & Services
GA E5PQ1
UT WOS:000976063300001
PM 37118750
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Al-Abdulla, R
   Ferrero, H
   Soriano, S
   Boronat-Belda, T
   Alonso-Magdalena, P
AF Al-Abdulla, Ruba
   Ferrero, Hilda
   Soriano, Sergi
   Boronat-Belda, Talia
   Alonso-Magdalena, Paloma
TI Screening of Relevant Metabolism-Disrupting Chemicals on Pancreatic
   β-Cells: Evaluation of Murine and Human In Vitro Models
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE metabolism-disrupting chemicals; pancreatic beta-cell; diabetes;
   metabolic disorders; insulin secretion; electrical activity
ID DI(2-ETHYLHEXYL) PHTHALATE DEHP; GLUCOSE-HOMEOSTASIS; INSULIN-SECRETION;
   BISPHENOL-A; EXPOSURE; ASSOCIATION; MECHANISMS; CHANNELS; CADMIUM;
   STRESS
AB Endocrine-disrupting chemicals (EDCs) are chemical substances that can interfere with the normal function of the endocrine system. EDCs are ubiquitous and can be found in a variety of consumer products such as food packaging materials, personal care and household products, plastic additives, and flame retardants. Over the last decade, the impact of EDCs on human health has been widely acknowledged as they have been associated with different endocrine diseases. Among them, a subset called metabolism-disrupting chemicals (MDCs) is able to promote metabolic changes that can lead to the development of metabolic disorders such as diabetes, obesity, hepatic steatosis, and metabolic syndrome, among others. Despite this, today, there are still no definitive and standardized in vitro tools to support the metabolic risk assessment of existing and emerging MDCs for regulatory purposes. Here, we evaluated the following two different pancreatic cell-based in vitro systems: the murine pancreatic beta-cell line MIN6 as well as the human pancreatic beta-cell line EndoC-beta H1. Both were challenged with the following range of relevant concentrations of seven well-known EDCs: (bisphenol-A (BPA), bisphenol-S (BPS), bisphenol-F (BPF), perfluorooctanesulfonic acid (PFOS), di(2-ethylhexyl) phthalate (DEHP), cadmium chloride (CdCl2), and dichlorodiphenyldichloroethylene (DDE)). The screening revealed that most of the tested chemicals have detectable, deleterious effects on glucose-stimulated insulin release, insulin content, electrical activity, gene expression, and/or viability. Our data provide new molecular information on the direct effects of the selected chemicals on key aspects of pancreatic beta-cell function, such as the stimulus-secretion coupling and ion channel activity. In addition, we found that, in general, the sensitivity and responses were comparable to those from other in vivo studies reported in the literature. Overall, our results suggest that both systems can serve as effective tools for the rapid screening of potential MDC effects on pancreatic beta-cell physiology as well as for deciphering and better understanding the molecular mechanisms that underlie their action.
C1 [Al-Abdulla, Ruba; Ferrero, Hilda; Soriano, Sergi; Boronat-Belda, Talia; Alonso-Magdalena, Paloma] Univ Miguel Hernandez, Inst Invest Desarrollo & Innovac Biotecnol Sanita, Elche 03202, Spain.
   [Ferrero, Hilda; Alonso-Magdalena, Paloma] Ctr Invest Biomed Red Diabet & Enfermedades Metab, Madrid 28029, Spain.
   [Soriano, Sergi] Univ Alicante, Dept Fisiol Genet & Microbiol, Alicante 03690, Spain.
C3 Universidad Miguel Hernandez de Elche; CIBER - Centro de Investigacion
   Biomedica en Red; CIBERDEM; Universitat d'Alacant
RP Alonso-Magdalena, P (corresponding author), Univ Miguel Hernandez, Inst Invest Desarrollo & Innovac Biotecnol Sanita, Elche 03202, Spain.; Alonso-Magdalena, P (corresponding author), Ctr Invest Biomed Red Diabet & Enfermedades Metab, Madrid 28029, Spain.
EM ral@umh.es; hferrero@umh.es; sergi.soriano@ua.es; tboronat@umh.es;
   palonso@umh.es
RI Al Abdulla, Ruba/ABH-3686-2020; Alonso-Magdalena, Paloma/AAH-2076-2021;
   Boronat Belda, Talía/GYD-4123-2022; Soriano, Sergi/M-5255-2017
OI ALONSO MAGDALENA, PALOMA/0000-0003-1065-5388; Al-Abdulla,
   Ruba/0000-0002-5194-9801; Soriano, Sergi/0000-0001-9844-7027; Ferrero,
   Hilda/0000-0001-7960-7523; Boronat-Belda, Talia/0000-0002-6548-5251
FU European Union [825712]; MCIN/AEI [PID2020-113112RB-I00]
FX This study received funding from the European Union's Horizon 2020
   Research and Innovation programme under Grant agreement no 825712
   (OBERON) project. The author's laboratory also holds grant
   PID2020-113112RB-I00 funded by MCIN/AEI/10.13039/501100011033. CIBERDEM
   is an initiative of the Instituto de Salud Carlos III.
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NR 79
TC 16
Z9 16
U1 6
U2 27
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD APR
PY 2022
VL 23
IS 8
AR 4182
DI 10.3390/ijms23084182
PG 29
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 0S2ZD
UT WOS:000786146700001
PM 35457000
OA Green Submitted, gold, Green Published
DA 2025-06-11
ER

PT J
AU Cheshmazar, E
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   Yazdani, B
   Razmpoosh, E
   Zarrati, M
AF Cheshmazar, Elhameh
   Hosseini, Agha Fatemeh
   Yazdani, Bahareh
   Razmpoosh, Elham
   Zarrati, Mitra
TI Effects of Vitamin D Supplementation on Omentin-1 and Spexin Levels,
   Inflammatory Parameters, Lipid Profile, and Anthropometric Indices in
   Obese and Overweight Adults with Vitamin D Deficiency under Low-Calorie
   Diet: A Randomized Placebo Controlled Trial
SO EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Article
ID NONALCOHOLIC FATTY LIVER; C-REACTIVE PROTEIN; WEIGHT-LOSS; DOUBLE-BLIND;
   METABOLIC SYNDROME; POSTMENOPAUSAL WOMEN; OXIDATIVE STRESS;
   ADIPOSE-TISSUE; BIOMARKERS; ADIPOKINES
AB Background and Aims. Improved vitamin D levels can have a favorable effect on some metabolic variables. The objective of the current study was to determine the effects of vitamin D supplementation during a weight-loss intervention on the levels of omentin-1, spexin, lipid profiles, and inflammatory factors in obese and overweight participants. Methods and Materials. In this double-blind placebo-controlled randomized clinical trial, 70 overweight and obese participants with vitamin D deficiency (25(OH)D <= 20 nmol/L) were assigned into the intervention (a daily dose of 2,000 IU vitamin D + low-calorie diet) and placebo (placebo + low-calorie diet) groups for 8 weeks. Anthropometric parameters, serum levels of 25-hydroxy vitamin D (25(OH)D), lipid profiles, omentin-1 and spexin levels, high-sensitivity C-reactive protein (hs-CRP), and soluble intercellular adhesion molecule-1 (sICAM-1) concentrations were assessed before and after the intervention. Results. Vitamin D supplementation after the intervention led to a significant decrease in triglycerides (TG) (P=0.02), very-low-density lipoprotein-cholesterol (VLDL-C) (P=0.02), and hs-CRP (P=0.03) concentrations and a significant increase in the serum vitamin D level (P<0.001). Furthermore, after adjusting for baseline values, age, and baseline BMI, the levels of serum high-density lipoprotein-cholesterol (HDL-C) (P=0.01) increased significantly, and a significant reduction was observed in the concentration of sICAM-1 (P=0.01) in the intervention group. However, we did not find any significant difference in serum omentin-1 and spexin concentrations between the groups after intervention. Conclusions. Vitamin D supplementation along with a low-calorie diet (LCD) program for 8 weeks significantly decreased the inflammatory markers in obese individuals, while it did not alter serum omentin-1 and spexin concentrations.
C1 [Cheshmazar, Elhameh; Zarrati, Mitra] Iran Univ Med Sci, Sch Publ Hlth, Dept Nutr, Tehran, Iran.
   [Hosseini, Agha Fatemeh] Iran Univ Med Sci, Sch Publ Hlth, Dept Biostat, Tehran, Iran.
   [Yazdani, Bahareh] Nilou Lab, Neonatal Screening Dept, Tehran, Iran.
   [Razmpoosh, Elham] Shahid Beheshti Univ Med Sci, Res Inst Endocrine Sci, Nutr & Endocrine Res Ctr, Tehran, Iran.
   [Razmpoosh, Elham] ACECR, Motamed Canc Inst, Integrat Oncol & Qual Life Dept, Breast Canc Res Ctr, Tehran, Iran.
C3 Iran University of Medical Sciences; Iran University of Medical
   Sciences; Shahid Beheshti University Medical Sciences; Academic Center
   for Education, Culture & Research (ACECR)
RP Zarrati, M (corresponding author), Iran Univ Med Sci, Sch Publ Hlth, Dept Nutr, Tehran, Iran.
EM cheshmazar.elham@yahoo.com; fatemeh_h@yahoo.com; bahareh1156@gmail.com;
   e_razmpoosh@yahoo.com; zarrati_ms@yahoo.com
RI HOSSEINI, AGHA/H-6302-2018; Razmpoosh, Elham/S-4133-2016
OI Hossini, fateme/0009-0003-8368-1453
FU Iran University of Medical Sciences (IUMS) [26191]
FX This study was supported by the Iran University of Medical Sciences
   (IUMS) (Grant no. 26191).
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NR 45
TC 12
Z9 13
U1 0
U2 6
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1741-427X
EI 1741-4288
J9 EVID-BASED COMPL ALT
JI Evid.-based Complement Altern. Med.
PD NOV 11
PY 2020
VL 2020
AR 3826237
DI 10.1155/2020/3826237
PG 10
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA PA4XA
UT WOS:000595639400005
PM 33224249
OA Green Published, Green Submitted, hybrid
DA 2025-06-11
ER

PT J
AU Pazos, F
AF Pazos, Fernando
TI Range of adiposity and cardiorenal syndrome
SO WORLD JOURNAL OF DIABETES
LA English
DT Review
DE Obesity; Morbid obesity; Cardiorenal syndrome; Heart failure; Chronic
   kidney disease
ID CHRONIC KIDNEY-DISEASE; DECOMPENSATED HEART-FAILURE; REDUCED EJECTION
   FRACTION; WORSENING RENAL-FUNCTION; BODY-MASS INDEX;
   ANGIOTENSIN-ALDOSTERONE SYSTEM; OBESITY-INDUCED HYPERTENSION; BASE-LINE
   CHARACTERISTICS; BARIATRIC SURGERY; WEIGHT-LOSS
AB Obesity and obesity-related co-morbidities, diabetes mellitus, and hypertension are among the fastest-growing risk factors of heart failure and kidney disease worldwide. Obesity, which is not a unitary concept, or a static process, ranges from alterations in distribution to the amount of adiposity. Visceral adiposity, which includes intraabdominal visceral fat mass and ectopic fat deposition such as hepatic, cardiac, or renal, was robustly associated with a greater risk for cardiorenal morbidity than subcutaneous adiposity. In addition, morbid obesity has also demonstrated a negative effect on cardiac and renal functioning. The mechanisms by which adipose tissue is linked with the cardiorenal syndrome (CRS) are hemodynamic and mechanical changes, as well neurohumoral pathways such as insulin resistance, endothelial dysfunction, nitric oxide bioavailability, renin-angiotensin-aldosterone, oxidative stress, sympathetic nervous systems, natriuretic peptides, adipokines and inflammation. Adiposity and other associated co-morbidities induce adverse cardiac remodeling and interstitial fibrosis. Heart failure with preserved ejection fraction has been associated with obesity-related functional and structural abnormalities. Obesity might also impair kidney function through hyperfiltration, increased glomerular capillary wall tension, and podocyte dysfunction, which leads to tubulointerstitial fibrosis and loss of nephrons and, finally, chronic kidney disease. The development of new treatments with renal and cardiac effects in the context of type 2 diabetes, which improves mortality outcome, has highlighted the importance of CRS and its prevalence. Increased body fat triggers cellular, neuro-humoral and metabolic pathways, which create a phenotype of the CRS with specific cellular and biochemical biomarkers. Obesity has become a single cardiorenal umbrella or type of cardiorenal metabolic syndrome. This review article provides a clinical overview of the available data on the relationship between a range of adiposity and CRS, the support for obesity as a single cardiorenal umbrella, and the most relevant studies on the recent therapeutic approaches.
C1 [Pazos, Fernando] Cantabria Univ, Dept Med, Med Fac, Valdecilla Hosp, POB 2257, Santander 39080, Cantabria, Spain.
C3 Universidad de Cantabria; Hospital Universitario Marques de Valdecilla
   (HUMV)
RP Pazos, F (corresponding author), Cantabria Univ, Dept Med, Med Fac, Valdecilla Hosp, POB 2257, Santander 39080, Cantabria, Spain.
EM fernandoantonio.pazos@scsalud.es
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NR 200
TC 17
Z9 17
U1 0
U2 1
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 7041 Koll Center Parkway, Suite 160, PLEASANTON, CA, UNITED STATES
EI 1948-9358
J9 WORLD J DIABETES
JI World J. Diabetes
PD AUG 15
PY 2020
VL 11
IS 8
DI 10.4239/wjd.v11.i8.322
PG 30
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA NF8QW
UT WOS:000563558600001
PM 32864046
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Chapman, CL
   Grigoryan, T
   Vargas, NT
   Reed, EL
   Kueck, PJ
   Pietrafesa, LD
   Bloomfield, AC
   Johnson, BD
   Schlader, ZJ
AF Chapman, Christopher L.
   Grigoryan, Tigran
   Vargas, Nicole T.
   Reed, Emma L.
   Kueck, Paul J.
   Pietrafesa, Leonard D.
   Bloomfield, Adam C.
   Johnson, Blair D.
   Schlader, Zachary J.
TI High-fructose corn syrup-sweetened soft drink consumption increases
   vascular resistance in the kidneys at rest and during sympathetic
   activation
SO AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
LA English
DT Article
DE Doppler ultrasound; renal blood velocity; renal vascular resistance;
   soda; vasopressin; uric acid
ID METABOLIC SYNDROME; URIC-ACID; HEAT-STRESS; BLOOD-PRESSURE;
   HYPERTENSION; VASOPRESSIN; DISEASE; VASOCONSTRICTION; HYPERURICEMIA;
   FRUCTOKINASE
AB We first tested the hypothesis that consuming a high-fructose corn syrup (HFCS)-sweetened soft drink augments kidney vasoconstriction to sympathetic stimulation compared with water (study 1). In a second study, we examined the mechanisms underlying these observations (study 2). In study 1, 13 healthy adults completed a cold pressor test, a sympathoexcitatory maneuver, before (preconsumption) and 30 min after drinking 500 mL of decarbonated HFCS-sweetened soft drink or water (postconsumption). In study 2, venous blood samples were obtained in 12 healthy adults before and 30 min after consumption of 500 mL water or soft drinks matched for caffeine content and taste, which were either artificially sweetened (Diet trial), sucrose-sweetened (Sucrose trial), or sweetened with HFCS (HFCS trial). In both study 1 and study 2, vascular resistance was calculated as mean arterial pressure divided by blood velocity, which was measured via Doppler ultrasound in renal and segmental arteries. In study 1, HFCS consumption increased vascular resistance in the segmental artery at rest (by 0.5 +/- 0.6 mmHg.cm(-1).s(-1), P = 0.01) and during the cold pressor test (average change: 0.5 +/- 1.0 mmHg.cm(-1).s(-1), main effect: P = 0.05). In study 2, segmental artery vascular resistance increased in the HFCS trial (by 0.8 +/- 0.7 mmHg.cm(-1).s(-1), P = 0.02) but not in the other trials. Increases in serum uric acid were greater in the HFCS trial (0.3 +/- 0.4 mg/dL, P = 0.04) compared with the Water and Diet trials, and serum copeptin increased in the HFCS trial (by 0.8 +/- 1.0 pmol/L, P = 0.06). These findings indicate that HFCS acutely increases vascular resistance in the kidneys, independent of caffeine content and beverage osmolality, which likely occurs via simultaneous elevations in circulating uric acid and vasopressin.
C1 [Chapman, Christopher L.; Grigoryan, Tigran; Vargas, Nicole T.; Reed, Emma L.; Kueck, Paul J.; Pietrafesa, Leonard D.; Bloomfield, Adam C.; Johnson, Blair D.; Schlader, Zachary J.] Univ Buffalo, Ctr Res & Educ Special Environm, Dept Exercise & Nutr Sci, Buffalo, NY USA.
   [Schlader, Zachary J.] Indiana Univ, Dept Kinesiol, Sch Publ Hlth, Bloomington, IN 47405 USA.
C3 State University of New York (SUNY) System; University at Buffalo, SUNY;
   Indiana University System; Indiana University Bloomington
RP Schlader, ZJ (corresponding author), Indiana Univ, Dept Kinesiol, Rm 112,1025 E 7th St, Bloomington, IN 47405 USA.
EM zschlade@indiana.edu
RI Vargas, Nicole/AAG-7349-2020
OI Vargas, Nicole/0000-0002-2634-7120; Johnson, Blair/0000-0002-1731-4415;
   Schlader, Zachary/0000-0003-3590-3958; Chapman,
   Christopher/0000-0001-9717-4776; Chapman,
   Christopher/0000-0001-8251-9356
FU United States Centers for Disease Control and Prevention [R01-OH-011528]
FX This work was partially supported by United States Centers for Disease
   Control and Prevention Grant R01-OH-011528.
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NR 49
TC 24
Z9 26
U1 0
U2 13
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 1931-857X
EI 1522-1466
J9 AM J PHYSIOL-RENAL
JI Am. J. Physiol.-Renal Physiol.
PD APR
PY 2020
VL 318
IS 4
BP F1053
EP F1065
DI 10.1152/ajprenal.00374.2019
PG 13
WC Physiology; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology; Urology & Nephrology
GA LD5ZZ
UT WOS:000526110200018
PM 32174139
OA Green Published
DA 2025-06-11
ER

PT J
AU Tabrizi, R
   Tamtaji, OR
   Lankarani, KB
   Akbari, M
   Dadgostar, E
   Dabbaghmanesh, MH
   Kolahdooz, F
   Shamshirian, A
   Momen-Heravi, M
   Asemi, Z
AF Tabrizi, Reza
   Tamtaji, Omid Reza
   Lankarani, Kamran B.
   Akbari, Maryam
   Dadgostar, Ehsan
   Dabbaghmanesh, Mohammad Hossein
   Kolahdooz, Fariba
   Shamshirian, Amir
   Momen-Heravi, Mansooreh
   Asemi, Zatollah
TI The effects of resveratrol intake on weight loss: a systematic review
   and meta-analysis of randomized controlled trials
SO CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
LA English
DT Review
DE Resveratrol; weight loss; overweight; meta-analysis
ID TYPE-2 DIABETES-MELLITUS; BLOOD MONONUCLEAR-CELLS; METABOLIC SYNDROME;
   INSULIN SENSITIVITY; CLINICAL-TRIAL; DOUBLE-BLIND; OXIDATIVE STRESS;
   SUPPLEMENTATION; OBESITY; IMPROVES
AB This systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted to summarize the effect of resveratrol intake on weight loss. We searched the following databases until July 2018: MEDLINE, EMBASE, Web of Science and Cochrane Central Register of Controlled Trials. Data were pooled using the inverse variance method and expressed as standardized mean difference (SMD) with 95% confidence intervals (95% CI). Out of 831 reports, 36 RCTs were eligible for including to our meta-analysis. The pooled results, using random-effects model showed that resveratrol supplementation significantly decreased body weight (SMD = -0.17; 95% CI, -0.33, -0.01; P = 0.03; I-2: 62.6), body mass index (BMI) (SMD = -0.20; 95% CI, -0.35, -0.05; P = 0.01; I-2: 60.6), fat mass (SMD = -0.32; 95% CI, -0.62, -0.03; P = 0.03; I-2: 77.9) and waist circumference (WC) (SMD = -0.42; 95% CI, -0.68, -0.16; P = 0.001; I-2: 75.2), and significantly increased lean mass (SMD = 1.21; 95% CI, 0.75, 1.67; P < 0.001; I-2: 87.6). We found no significant effect of resveratrol administration on leptin (SMD = -0.20; 95% CI, -0.68, 0.27; P = 0.40; I-2: 85.3) and adiponectin levels (SMD = 0.08; 95% CI, -0.39, 0.55; P = 0.74; I-2: 91.0). Resveratrol supplementation significantly decreased body weight in obese patients (SMD -0.43; 95% CI, -0.60, -0.26) compared with other diseases (SMD 0.02; 95% CI, -0.29, 0.33), and type 2 diabetes mellitus (SMD -0.17; 95% CI, -0.37, 0.02). Overall, the current meta-analysis demonstrated that resveratrol intake significantly reduced weight, BMI, WC and fat mass, and significantly increased lean mass, but did not affect leptin and adiponectin levels.
C1 [Tabrizi, Reza; Akbari, Maryam] Shiraz Univ Med Sci, Student Res Comm, Hlth Policy Res Ctr Inst Hlth, Shiraz, Iran.
   [Tamtaji, Omid Reza] Kashan Univ Med Sci, Physiol Res Ctr, Kashan, Iran.
   [Tamtaji, Omid Reza; Dadgostar, Ehsan] Halal Res Ctr IRI, FDA, Tehran, Iran.
   [Lankarani, Kamran B.] Shiraz Univ Med Sci, Hlth Policy Res Ctr, Shiraz, Iran.
   [Dabbaghmanesh, Mohammad Hossein] Shiraz Univ Med Sci, Nemazee Hosp, Endocrine & Metab Res Ctr, Dept Internal Med, Shiraz, Iran.
   [Kolahdooz, Fariba] Univ Alberta, Dept Med, Indigenous & Global Hlth Res, Edmonton, AB, Canada.
   [Shamshirian, Amir] Mazandaran Univ Med Sci, Sch Allied Med Sci, Student Res Comm, Dept Med Lab Sci, Sari, Iran.
   [Momen-Heravi, Mansooreh] Kashan Univ Med Sci, Sch Med, Dept Infect Dis, Kashan, Iran.
   [Momen-Heravi, Mansooreh] Kashan Univ Med Sci, Social Determinants Hlth Res Ctr, Kashan, Iran.
   [Asemi, Zatollah] Kashan Univ Med Sci, Res Ctr Biochem & Nutr Metab Dis, Kashan, Iran.
C3 Shiraz University of Medical Science; Shiraz University of Medical
   Science; Shiraz University of Medical Science; University of Alberta;
   Mazandaran University of Medical Sciences
RP Asemi, Z (corresponding author), Kashan Univ Med Sci, Res Ctr Biochem & Nutr Metab Dis, Kashan, Iran.
EM asemi_r@yahoo.com
RI asemi, zatollah/J-2677-2018; Akbari, Ali/G-6044-2016; Dabbaghmanesh,
   Mohammad/A-4906-2019; tamtaji, M/KWU-3655-2024; lankarani,
   kamran/D-5901-2012; Tabrizi, Reza/AAC-2486-2021; Shamshirian,
   Amir/K-4975-2017
OI Shamshirian, Amir/0000-0002-2735-0209; dadgostar,
   ehsan/0000-0002-4041-7324; tabrizi, reza/0000-0001-7634-3948;
   Dabbaghmanesh, Mohammad Hossein/0000-0002-4877-0376
FU SUMS, Shiraz; SUMS, Iran
FX The present study was supported by a grant from the Vice-chancellor for
   Research, SUMS, Shiraz, and Iran.
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NR 55
TC 75
Z9 78
U1 1
U2 26
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1040-8398
EI 1549-7852
J9 CRIT REV FOOD SCI
JI Crit. Rev. Food Sci. Nutr.
PD FEB 4
PY 2020
VL 60
IS 3
BP 375
EP 390
DI 10.1080/10408398.2018.1529654
PG 16
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA JZ5GY
UT WOS:000505131400002
PM 30421960
DA 2025-06-11
ER

PT J
AU Rui, YH
   Lv, ML
   Chang, J
   Xu, JY
   Qin, LQ
   Wan, ZX
AF Rui, Yehua
   Lv, Menglian
   Chang, Jie
   Xu, Jiaying
   Qin, Liqiang
   Wan, Zhongxiao
TI Chia Seed Does Not Improve Cognitive Impairment in SAMP8 Mice Fed with
   High Fat Diet
SO NUTRIENTS
LA English
DT Article
DE chia seed; Alzheimer's disease; amyloid; Tau; neuro-inflammation
ID SALVIA-HISPANICA L.; RANDOMIZED CONTROLLED-TRIAL; DISEASE RISK-FACTORS;
   INDUCED OBESE RATS; ALZHEIMERS-DISEASE; ADIPOSE-TISSUE; TAU PATHOLOGY;
   PROTEIN; OVERWEIGHT; GRAIN
AB Background: Chia seed is an ancient seed with the richest plant source of -linolenic acid, which has been demonstrated to improve metabolic syndrome associated risk factors. Under high fat diet (HFD) condition, the senescence-accelerated mouse-prone 8 (SAMP8) mice demonstrated worsen Alzheimer's disease (AD) related pathology compared to low fat diet fed SAMP8 mice. Objective: To explore whether chia seed supplementation might improve cognitive impairment under aging and metabolic stress via high fat diet (HFD) fed SAMP8 mice as a model. Design: SAMP8 mice and senescence-accelerated mouse-resistant 1 (SAMR1) were randomized into 4 groups, i.e., SAMR1 low fat diet group (SAMR1-LFD), SAMP8-HFD and SAMP8-HFD group supplemented with 10% chia seed (SAMP8-HFD+Chia). At the end of the intervention, cognitive function was measured via Morris water maze (MWM) test. Hippocampus and parietal cortex were dissected for further analysis to measure key markers involved AD pathology including A, tau and neuro-inflammation. Results: During navigation trials of MWM test, mice in SAMP8-LFD group demonstrated impaired learning ability compared to SAMR1-LFD group, and chia seed had no effect on learning and memory ability for HFD fed SAMP8 mice. As for Alzheimer's disease (AD) related pathology, chia seed not only increased -secretase such as ADAM10 and insulin degrading enzyme (IDE), but also increased -secretase including beta-secretase 1 (BACE1) and cathepsin B, with an overall effects of elevation in the hippocampal A(42) level; chia seed slightly reduced p-Tauser404 in the hippocampus; while an elevation in neuro-inflammation with the activation of glial fibrillary acidic protein (GFAP) and Ib-1 were observed post chia seed supplementation. Conclusions: Chia seed supplementation did not improve cognitive impairment via MWM in HFD fed SAMP8 mice. This might be associated with that chia seed increased key enzymes involved both in non-amyloidogenic and amyloidogenic pathways, and neuro-inflammation. Future studies are necessary to confirm our present study.
C1 [Rui, Yehua; Lv, Menglian; Qin, Liqiang; Wan, Zhongxiao] Soochow Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Suzhou 215123, Peoples R China.
   [Chang, Jie] Soochow Univ, Sch Publ Hlth, Dept Occupat & Environm Hlth, 199 Renai Rd, Suzhou 215123, Peoples R China.
   [Xu, Jiaying] Soochow Univ, Sch Radiat Med & Protect, 199 Renai Rd, Suzhou 215123, Peoples R China.
   [Wan, Zhongxiao] Soochow Univ, Jiangsu Key Lab Prevent & Translat Med Geriatr Di, 199 Renai Rd, Suzhou 215123, Peoples R China.
C3 Soochow University - China; Soochow University - China; Soochow
   University - China; Soochow University - China
RP Wan, ZX (corresponding author), Soochow Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Suzhou 215123, Peoples R China.; Wan, ZX (corresponding author), Soochow Univ, Jiangsu Key Lab Prevent & Translat Med Geriatr Di, 199 Renai Rd, Suzhou 215123, Peoples R China.
EM Ruiyehua2018@163.com; lvmenglian23@163.com; jchang@suda.edu.cn;
   xujiaying@suda.edu.cn; qinliqiang@suda.edu.cn; zhxwan@suda.edu.cn
RI xu, jiaying/ISA-2500-2023; Chang, Jie/AFR-8580-2022
OI Wan, Zhongxiao/0000-0002-6297-5933
FU Natural Science Foundation of China [81472975]; scientific and
   technological projects of Suzhou City [SYS201707]; National Key R&D
   Program of China [2017YFC1310700, 2017YFC1310701]
FX This research was funded by the Natural Science Foundation of China
   (grant NO. 81472975), scientific and technological projects of Suzhou
   City (grant NO. SYS201707) and the grant 2017YFC1310700, 2017YFC1310701
   from National Key R&D Program of China, and The APC was funded by the
   Natural Science Foundation of China (grant NO. 81472975).
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NR 41
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Z9 10
U1 0
U2 7
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 2072-6643
J9 NUTRIENTS
JI Nutrients
PD AUG
PY 2018
VL 10
IS 8
AR 1084
DI 10.3390/nu10081084
PG 15
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA GU9PD
UT WOS:000445680200132
PM 30110883
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Jazinaki, MS
   Rashidmayvan, M
   Pahlavani, N
AF Jazinaki, Mostafa Shahraki
   Rashidmayvan, Mohammad
   Pahlavani, Naseh
TI The effect of pomegranate juice supplementation on C-reactive protein
   levels: GRADE-assessed systematic review and dose-response updated
   meta-analysis of data from randomized controlled trials
SO PHYTOTHERAPY RESEARCH
LA English
DT Review
DE C-reactive protein; inflammation; meta-analysis; pomegranate juice;
   Punica juice; systematic review
ID CARDIOVASCULAR RISK-FACTORS; OXIDATIVE STRESS; SEED OIL; BLOOD-PRESSURE;
   NITRIC-OXIDE; EXTRACT SUPPLEMENTATION; ENDOTHELIAL FUNCTION; ANTIOXIDANT
   ACTIVITY; DENSITY-LIPOPROTEIN; METABOLIC SYNDROME
AB Pomegranate juice (PJ) has a possible anti-inflammatory effect because of its polyphenol content and antioxidants. However, the anti-inflammatory effect of PJ in randomized controlled trials (RCTs) has not been consistent. A previous meta-analysis conducted in 2016 reported a nonsignificant lowering effect of PJ on C-reactive protein (CRP) levels. This systematic review and meta-analysis aim to update the pooled effect size of PJ supplementation on CRP levels in RCT studies. PubMed, Scopus, and Web of Science databases were comprehensively searched until July 2023. Eligible studies were found by screening, their relevant data was extracted, and a risk of bias assessment was performed. The pooled effect size was calculated using a random effect model as the weighted mean difference (WMD) with a 95% confidence interval. This systematic review included 11 studies with 13 effect sizes and 696 participants. Meta-analysis showed that PJ supplementation led to a significant decrease in CRP levels compared to control groups (WMD: -2.55mg/L; 95%CI: -3.44 to -1.66; p<0.001). Subgroup analysis demonstrated the significant reduction effect of PJ on CRP levels in studies conducted on the both sexes or only females as well as Iranian population, individuals with 40years<less than or equal to>, type 2 diabetes, polycystic ovary syndrome, or trials that intervened with PJ dosage of <250ml/day. Meta-regression and dose-response analysis reported a nonsignificant linear and nonlinear relationship between intervention characteristics (duration and dose of PJ) and CRP changes. The current meta-analysis revealed that PJ supplemantation has a beneficial effect in improving CRP levels. It is recommended to understand this effect better, and find the optimal dose and duration of PJ supplementation to reduce CRP levels in the blood, and repeat meta-analysis after related RCTs are available. For the final proof of these effects, more detailed human studies are needed.
C1 [Jazinaki, Mostafa Shahraki] Mashhad Univ Med Sci, Dept Nutr, Fac Med, Mashhad, Razavi Khorasan, Iran.
   [Rashidmayvan, Mohammad] Gonabad Univ Med Sci, Sch Med, Dept Nutr Food Sci & Clin Biochem, Social Determinants Hlth Res Ctr, Gonabad, Iran.
   [Pahlavani, Naseh] Torbat Heydariyeh Univ Med Sci, Hlth Sci Res Ctr, Torbat Heydariyeh, Iran.
   [Pahlavani, Naseh] Torbat Heydariyeh Univ Med Sci, Social Determinants Hlth Res Ctr, Torbat Heydariyeh, Iran.
C3 Mashhad University of Medical Sciences
RP Pahlavani, N (corresponding author), Torbat Heydariyeh Univ Med Sci, Hlth Sci Res Ctr, Torbat Heydariyeh, Iran.
EM nasehpahlavanine91@yahoo.com
RI Pahlavani, Naseh/Y-5149-2019; Rashidmayvan, mohammad/HTP-3902-2023
OI Pahlavani, Naseh/0000-0001-7960-7267
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NR 88
TC 1
Z9 1
U1 0
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0951-418X
EI 1099-1573
J9 PHYTOTHER RES
JI Phytother. Res.
PD JUN
PY 2024
VL 38
IS 6
BP 2818
EP 2831
DI 10.1002/ptr.8188
EA MAR 2024
PG 14
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA UL6N1
UT WOS:001193674500001
PM 38553998
DA 2025-06-11
ER

PT J
AU Gustaite, S
   Everatt, V
   Kairiene, I
   Vaisnore, R
   Rascon, J
   Vaitkeviciene, GE
AF Gustaite, Sigita
   Everatt, Veronika
   Kairiene, Igne
   Vaisnore, Ramune
   Rascon, Jelena
   Vaitkeviciene, Goda Elizabeta
TI Changes in Nutritional Status during Induction Phase and Their
   Association with Fever and Minimal Residual Disease in Paediatric Acute
   Lymphoblastic Leukaemia
SO MEDICINA-LITHUANIA
LA English
DT Article
DE acute lymphoblastic leukaemia; nutrition; body mass index; fever;
   minimal residual disease
ID BODY-MASS INDEX; METABOLIC SYNDROME; CHILDREN; OBESITY; CHEMOTHERAPY;
   MALNUTRITION; INFECTION; SURVIVAL; THERAPY; BIRTH
AB Background and objectives: Acute lymphoblastic leukaemia (ALL) is associated with a cytokine imbalance and oxidative stress, which can be aggravated by malnutrition. Malnutrition, defined by the World Health Organisation (WHO) as obesity or undernutrition, can affect treatment complications and outcomes. Therefore, we aimed to analyse the change in the body mass index (BMI) z-score during induction, as well as evaluate the impact of childhood malnutrition on fevers at an ALL presentation and early response to therapy. Methods: An observational cohort study of 50 consecutive children with ALL, diagnosed in 2019-2022, was performed. Patients were divided into age groups of 0-5, 6-11, and 12-17 years. BMI-for-age z-scores were used to define undernutrition and overnutrition according to WHO growth standards. Results: The number of patients with an abnormal BMI increased from 3 (6%) at diagnosis to 10 (20%) at the end of induction (from 2 (4%) to 6 (12%) in overweight/obese, and from 1 (2%) to 4 (8%) in underweight patients). At the end of induction, all overweight/obese patients were 0-5 years old. On the other hand, a statistically significant decrease in the mean BMI z-score among patients aged 12-17 was observed (p = 0.005). The mean BMI z-score differed statistically significantly among children aged 0-5 presenting with and without fever (p = 0.001). The minimal residual disease (MRD) level at the end of induction was not related to BMI at diagnosis. Conclusions: Despite the use of steroids, adolescents are prone to losing weight during an ALL induction, in contrast to preschool children, who tend to gain weight under the same treatment. BMI at diagnosis was related to a fever of & GE;38 & DEG;C (at ALL presentation) in the 0-5 age group. The results emphasise the importance of careful nutritional status monitoring, with younger and older children as important target groups for weight gain and weight loss interventions, respectively.
C1 [Gustaite, Sigita; Everatt, Veronika; Kairiene, Igne; Rascon, Jelena; Vaitkeviciene, Goda Elizabeta] Vilnius Univ, Fac Med, LT-03101 Vilnius, Lithuania.
   [Vaisnore, Ramune] Vilnius Univ Hosp Santaros Klin, Reference Ctr Oncohaematol Dis, Haematol Oncol & Transfus Med Ctr, LT-08661 Vilnius, Lithuania.
C3 Vilnius University
RP Gustaite, S; Everatt, V (corresponding author), Vilnius Univ, Fac Med, LT-03101 Vilnius, Lithuania.
EM sigita.gustaite@mf.stud.vu.lt; sigita.gustaite@gmail.com
RI Everatt, Veronika/KIG-7352-2024; Rascon, Jelena/E-5513-2012;
   Vaitkeviciene, Goda/ABE-6910-2022
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NR 47
TC 2
Z9 2
U1 0
U2 3
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1010-660X
EI 1648-9144
J9 MEDICINA-LITHUANIA
JI Med. Lith.
PD JUN
PY 2023
VL 59
IS 6
AR 1008
DI 10.3390/medicina59061008
PG 11
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA K3GQ7
UT WOS:001015359900001
PM 37374212
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU González, F
   Considine, RV
   Abdelhadi, OA
   Xue, JP
   Acton, AJ
AF Gonzalez, Frank
   Considine, Robert, V
   Abdelhadi, Ola A.
   Xue, Jiaping
   Acton, Anthony J.
TI Saturated fat ingestion stimulates proatherogenic inflammation in
   polycystic ovary syndrome
SO AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
LA English
DT Article
DE atherogenesis; abdominal adiposity; hyperandrogenism; polycystic ovary
   syndrome; saturated fat
ID C-REACTIVE PROTEIN; EXCESS ABDOMINAL ADIPOSITY; INDUCED OXIDATIVE
   STRESS; NORMAL-WEIGHT WOMEN; INSULIN-RESISTANCE; GLUCOSE-INGESTION;
   MATRIX METALLOPROTEINASES; METABOLIC SYNDROME; MONONUCLEAR-CELLS;
   YOUNG-WOMEN
AB Inflammation and dyslipidemia are often present in polycystic ovary syndrome (PCOS). We determined the effect of saturated fat ingestion on circulating heat shock protein-70 (HSP-70) and mononuclear cell (MNC) toll-like receptor-2 (TLR2) gene expression, activator protein-1 (AP-1) activation, and matrix matalloproteinase-2 (MMP-2) protein in women with PCOS. Twenty reproductive-age women with PCOS (10 lean, 10 with obesity) and 20 ovulatory controls (10 lean, 10 with obesity) participated in the study. HSP-70 was measured in serum and TLR2 mRNA and protein, AP-1 activation, and MMP-2 protein were quantified in MNC from blood drawn while fasting and 2, 3, and 5 h after saturated fat ingestion. Insulin sensitivity was derived from an oral glucose tolerance test (ISOGTT). Androgen secretion was assessed from blood drawn while fasting and 24, 48, and 72 h after human chorionic gonadotropin (HCG) administration. In response to saturated fat ingestion, serum HSP-70, TLR2 gene expression, activated AP-1, and MMP-2 protein were greater in lean women with PCOS compared with lean controls and in women with PCOS and obesity compared with controls with obesity. Both PCOS groups exhibited lower ISOGTT and greater HCG-stimulated androgen secretion compared with control subjects of their respective weight classes. Lipid-stimulated proatherogenic inflammation marker responses were negatively correlated with ISOGTT and positively correlated with abdominal adiposity and HCG-stimulated androgen secretion. In PCOS, saturated fat ingestion stimulates proatherogenic inflammation independent of obesity. This effect is greater when PCOS is combined with obesity compared with obesity alone. Abdominal adiposity and hyperandrogenism may perpetuate proatherogenic inflammation.
   NEW & NOTEWORTHY This paper demonstrates that in polycystic ovary syndrome (PCOS), ingestion of saturated fat triggers a molecular pathway of inflammation known to drive atherogenesis. This effect is independent of obesity as it occurs in lean women with PCOS and not in lean ovulatory control subjects. Furthermore, the combined effects of PCOS and obesity are greater compared with obesity alone.
C1 [Gonzalez, Frank; Xue, Jiaping] Univ Illinois, Dept Obstet & Gynecol, Chicago Coll Med, Chicago, IL 60612 USA.
   [Considine, Robert, V; Acton, Anthony J.] Indiana Univ Sch Med, Dept Med, Indianapolis, IN 46202 USA.
   [Abdelhadi, Ola A.] Indiana Univ Sch Med, Dept Obstet & Gynecol, Indianapolis, IN 46202 USA.
C3 University of Illinois System; University of Illinois Chicago;
   University of Illinois Chicago Hospital; Indiana University System;
   Indiana University Bloomington; Indiana University System; Indiana
   University Bloomington
RP González, F (corresponding author), Univ Illinois, Dept Obstet & Gynecol, Chicago Coll Med, Chicago, IL 60612 USA.
EM frgz12@uic.edu
FU National Institutes of Health [R01 DK107605]; Indiana Clinical and
   Translational Sciences Institute Clinical Research Center - National
   Institutes of Health, National Center for Advancing Translational
   Sciences, Clinical and Translational Sciences Award [UL1TR002529];
   Indiana University Center for Diabetes and Metabolic Diseases - National
   Institutes of Health [P30 DK097512]
FX This research was supported by grant R01 DK107605 to F.G. from the
   National Institutes of Health; the Indiana Clinical and Translational
   Sciences Institute Clinical Research Center which is funded in part by
   grant UL1TR002529 from the National Institutes of Health, National
   Center for Advancing Translational Sciences, Clinical and Translational
   Sciences Award; and the Indiana University Center for Diabetes and
   Metabolic Diseases funded by grant P30 DK097512 from the National
   Institutes of Health.
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NR 66
TC 9
Z9 10
U1 0
U2 14
PU AMER PHYSIOLOGICAL SOC
PI Rockville
PA 6120 Executive Blvd, Suite 600, Rockville, MD, UNITED STATES
SN 0193-1849
EI 1522-1555
J9 AM J PHYSIOL-ENDOC M
JI Am. J. Physiol.-Endocrinol. Metab.
PD NOV
PY 2021
VL 321
IS 5
BP E689
EP E701
DI 10.1152/ajpendo.00213.2021
PG 13
WC Endocrinology & Metabolism; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Physiology
GA XE8KK
UT WOS:000723630800005
PM 34632798
OA Green Published
DA 2025-06-11
ER

PT J
AU Cui, N
   Cui, J
   Sun, JP
   Xu, XP
   Aslam, B
   Bai, L
   Li, DC
   Wu, D
   Ma, ZR
   Gu, H
   Baloch, Z
AF Cui, Nan
   Cui, Jing
   Sun, Jianping
   Xu, Xinping
   Aslam, Bilal
   Bai, Lan
   Li, Decheng
   Wu, Di
   Ma, Zhongren
   Gu, Hai
   Baloch, Zulqarnain
TI Triglycerides and Total Cholesterol Concentrations in Association with
   Hyperuricemia in Chinese Adults in Qingdao, China
SO RISK MANAGEMENT AND HEALTHCARE POLICY
LA English
DT Article
DE triglycerides; total cholesterol; hyperuricemia; Qingdao; Chinese
   population
ID METABOLIC SYNDROME; URIC-ACID; OXIDATIVE STRESS; SIRT1; ROLES; RISK;
   GOUT
AB Objective: To assess the association between triglycerides (TG), total cholesterol (TC) and hyperuricemia (HUA) in the general Chinese population.
   Methods: A population-based cross-sectional survey included 9680 participants aged 35-74 years in 2006 and 2009 in Qingdao, China. TG, TC and uric acid (UA) were measured. The logistic regression model was performed to estimate the association between TG, TC, and HUA with an odds ratio (OR) and 95% confidence intervals (CI). Meanwhile, age stratification analysis (<= 55 years group and >= 55 years group) was performed to evaluate whether age potentially affects the association between TG, TC and HUA using multivariable logistic regression.
   Results: Higher TG and TC showed significantly increased HUA prevalence in both men and women (P(trend )all <0.05). Multivariate logistic regression indicated that borderline high TG (OR: 1.68, 95% CI: 1.31, 2.15 and HTG (OR: 2.98, 95% CI: 2.39, 3.72) indicated increased risk for HUA in men, and borderline high TG (OR: 2.09; 95% CI: 1.68,2.62); HTG (OR: 3.62; 95% CI: 2.90,4.51), borderline high TC (OR: 2.09, 95% CI: 1.68, 2.62) and HTC (OR: 3.62, 95% CI: 2.90, 4.51) showed significant association with HUA in women after adjusted age, school years, marital status, geographic division, personal monthly income, BMI and HDL-C. Age stratification analyses demonstrated that the association between TG and HUA was stronger in males aged >= 55 years and female aged <55 years, and the association between TC and HUA was stronger in both gender aged <55 years.
   Conclusion: This large cross-sectional study focusing on the association between single indictor of blood lipid as exposure and HUA as outcome on the east coast of China for the first time. From a sample of Chinese adults, this study demonstrated that elevated TG in men and women and TC in women were associated with increased HUA prevalence.
C1 [Cui, Nan; Xu, Xinping; Bai, Lan; Li, Decheng; Wu, Di; Gu, Hai] Nanjing Univ, Res Ctr Hlth Policy & Management, 101 Longmian Ave, Nanjing 210093, Peoples R China.
   [Cui, Jing; Sun, Jianping] Qingdao Ctr Dis Control & Prevent, Qingdao Inst Prevent Med, Qingdao, Peoples R China.
   [Aslam, Bilal; Ma, Zhongren; Baloch, Zulqarnain] Northwest Minzu Univ, Biomed Res Ctr, Minying Rd, Lanzhou 730030, Peoples R China.
   [Aslam, Bilal] Govt Coll Univ Faisalabad, Dept Microbiol, Faisalabad, Punjab, Pakistan.
C3 Nanjing University; Northwest Minzu University; Government College
   University Faisalabad
RP Gu, H (corresponding author), Nanjing Univ, Res Ctr Hlth Policy & Management, 101 Longmian Ave, Nanjing 210093, Peoples R China.; Baloch, Z (corresponding author), Northwest Minzu Univ, Biomed Res Ctr, Minying Rd, Lanzhou 730030, Peoples R China.
EM njuhaigu@126.com; znbalooch@yahoo.com
RI Xu, Xinping/HNI-8126-2023; wu, di/IYS-9217-2023; baloch, Dr.
   Zulqarnain/A-8455-2017; Aslam, Bilal/AAX-6227-2020
OI baloch, Dr. Zulqarnain/0000-0002-7873-1343; Aslam,
   Bilal/0000-0002-5568-5049
FU Qingdao Diabetes Prevention Program [WDF05-108, WDF07-308]; World
   Diabetes Foundation [WDF05-108, WDF07-308]; Qingdao Science & Technology
   department program [19-6-1-5-nsh]; Qingdao Outstanding Health
   Professional Development Fund
FX This work was supported by grants from Qingdao Diabetes Prevention
   Program and World Diabetes Foundation (WDF05-108 and WDF07-308), Qingdao
   Science & Technology department program (19-6-1-5-nsh) and Qingdao
   Outstanding Health Professional Development Fund.
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NR 42
TC 6
Z9 10
U1 1
U2 14
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
EI 1179-1594
J9 RISK MANAG HEALTHC P
JI RISK MANAG. HEALTHC. POLICY
PY 2020
VL 13
BP 165
EP 173
DI 10.2147/RMHP.S243381
PG 9
WC Health Care Sciences & Services; Health Policy & Services
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services
GA KU9VU
UT WOS:000520073200001
PM 32184687
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Lizarbe, B
   Soares, AF
   Larsson, S
   Duarte, JMN
AF Lizarbe, Blanca
   Soares, Ana Francisca
   Larsson, Sara
   Duarte, Joao M. N.
TI Neurochemical Modifications in the Hippocampus, Cortex and Hypothalamus
   of Mice Exposed to Long-Term High-Fat Diet
SO FRONTIERS IN NEUROSCIENCE
LA English
DT Article
DE glucose; insulin; diabetes; brain metabolism; synaptic dysfunction;
   gliosis
ID CENTRAL-NERVOUS-SYSTEM; N-ACETYLASPARTATE; IN-VIVO; RAT-BRAIN;
   INSULIN-RECEPTORS; OXIDATIVE STRESS; MR SPECTROSCOPY; MEMBRANE;
   NEUROINFLAMMATION; METABOLISM
AB Metabolic syndrome and diabetes impact brain function and metabolism. While it is well established that rodents exposed to diets rich in saturated fat develop brain dysfunction, contrasting results abound in the literature, likely as result of exposure to different high-fat diet (HFD) compositions and for varied periods of time. In the present study, we investigated alterations of hippocampal-dependent spatial memory by measuring Y-maze spontaneous alternation, metabolic profiles of the hippocampus, cortex and hypothalamus by H-1 magnetic resonance spectroscopy (MRS), and levels of proteins specific to synaptic and glial compartments in mice exposed for 6 months to different amounts of fat (10, 45, or 60% of total energy intake). Increasing the dietary amount of fat from 10 to 45% or 60% resulted in obesity accompanied by increased leptin, fasting blood glucose and insulin, and reduced glucose tolerance. In comparison to controls (10%-fat), only mice fed the 60%-fat diet showed increased fed glycemia, as well as plasma corticosterone that has a major impact on brain function. HFD-induced metabolic profile modifications measured by H-1 MRS were observed across the three brain areas in mice exposed to 60%- but not 45%-fat diet, while both HFD groups displayed impaired hippocampal-dependent memory. HFD also affected systems involved in neuro- or gliotransmission in the hippocampus. Namely, relative to controls, 60%-fat-fed mice showed reduced SNAP-25, PSD-95 and syntaxin-4 immunoreactivity, while 45%-fat-fed mice showed reduced gephyrin and syntaxin-4 immunoreactivity. For both HFD levels, reductions of the vesicular glutamate transporter vGlut1 and levels of the vesicular GABA transporter were observed in the hippocampus and hypothalamus, relative to controls. Immunoreactivity against GFAP and/or Iba-1 in the hypothalamus was higher in mice exposed to HFD than controls, suggesting occurrence of gliosis. We conclude that different levels of dietary fat result in distinct neurochemical alterations in the brain.
C1 [Lizarbe, Blanca; Soares, Ana Francisca] Ecole Polytech Fed Lausanne, Lab Funct & Metab Imaging, Lausanne, Switzerland.
   [Lizarbe, Blanca] Univ Autonoma Madrid, CSIC, Inst Invest Biomed Alberto Sols, Madrid, Spain.
   [Larsson, Sara; Duarte, Joao M. N.] Lund Univ, Fac Med, Dept Expt Med Sci, Lund, Sweden.
   [Larsson, Sara; Duarte, Joao M. N.] Lund Univ, Wallenberg Ctr Mol Med, Fac Med, Lund, Sweden.
C3 Swiss Federal Institutes of Technology Domain; Ecole Polytechnique
   Federale de Lausanne; Autonomous University of Madrid; Consejo Superior
   de Investigaciones Cientificas (CSIC); CSIC - Instituto de
   Investigaciones Biomedicas Alberto Sols (IIBM); Lund University; Lund
   University
RP Duarte, JMN (corresponding author), Lund Univ, Fac Med, Dept Expt Med Sci, Lund, Sweden.; Duarte, JMN (corresponding author), Lund Univ, Wallenberg Ctr Mol Med, Fac Med, Lund, Sweden.
EM joao.duarte@med.lu.se
RI Lizarbe, Blanca/KVZ-2861-2024; Duarte, Joao/H-4887-2012
OI Lizarbe, Blanca/0000-0002-5531-4088; Duarte, Joao/0000-0001-5984-1574
FU Knut and Alice Wallenberg Foundation; Swedish Research Council
   (Strategic Research Area EXODIAB) [2009-1039]; Swedish Foundation for
   Strategic Research [IRC15-0067]; Community of Madrid, Spain
   [S2017/BMD-3688 MULTITARGETVIEW-CM]; Swiss National Science Foundation
   [148250]; Centre d'Imagerie BioMedicale (CIBM) of the UNIL; Centre
   d'Imagerie BioMedicale (CIBM) of the UNIGE; Centre d'Imagerie
   BioMedicale (CIBM) of the HUG; Centre d'Imagerie BioMedicale (CIBM) of
   the CHUV; Centre d'Imagerie BioMedicale (CIBM) of the EPFL; Leenaards
   Foundation; Jeantet Foundation
FX This work was supported by the Knut and Alice Wallenberg Foundation, the
   Swedish Research Council (Strategic Research Area EXODIAB, grant
   2009-1039), the Swedish Foundation for Strategic Research (grant
   IRC15-0067), the Community of Madrid, Spain (grant S2017/BMD-3688
   MULTITARGET&VIEW-CM), the Swiss National Science Foundation (grant
   148250), and the Centre d'Imagerie BioMedicale (CIBM) of the UNIL,
   UNIGE, HUG, CHUV, EPFL, and the Leenaards and Jeantet Foundations.
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NR 73
TC 94
Z9 106
U1 1
U2 20
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1662-453X
J9 FRONT NEUROSCI-SWITZ
JI Front. Neurosci.
PD JAN 8
PY 2019
VL 12
AR 985
DI 10.3389/fnins.2018.00985
PG 15
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA HG6ZV
UT WOS:000455138200001
PM 30670942
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Patik, JC
   Christmas, KM
   Hurr, C
   Brothers, RM
AF Patik, Jordan C.
   Christmas, Kevin M.
   Hurr, Chansol
   Brothers, R. Matthew
TI Impaired endothelium independent vasodilation in the cutaneous
   microvasculature of young obese adults
SO MICROVASCULAR RESEARCH
LA English
DT Article
DE Obesity; Microvascular; Endothelium-independent; Nitric oxide; Sodium
   nitroprusside; Microdialysis
ID AGED HUMAN SKIN; NITRIC-OXIDE; METABOLIC SYNDROME; BLOOD-PRESSURE;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; DYSFUNCTION; GLUCOSE; HUMANS; FLOW
AB Microvascular dysfunction contributes to the development of cardiovascular and metabolic disease. This study tested the hypothesis that young obese (BMI > 30 kg m(-2)), otherwise healthy, adults (N = 15) have impaired microvascular function relative to age and sex matched, lean (BMI < 25 kg m(-2)) individuals (N = 14). Participants were instrumented with two microdialysis probes in the cutaneous vasculature of one forearm; one for a wide dose range of infusions of the endothelium-dependent vasodilator methacholine (MCh) and the other for the endothelium-independent vasodilator sodium nitroprusside (SNP). Local temperature at each site was clamped at 33 degrees C and cutaneous blood flow was indexed by laser Doppler flowmetry (LDF). LDF was recorded while 7 doses of each drug (MCh: 10(-6)-1 M; SNP: 5 x 10(-8)-5 x 10(-2) M) were infused at a rate of 2 mu l/min for 8 min per dose. Both sites finished with heating to 43 degrees C and 5 x 10(-2) M SNP to achieve site specific maximal vasodilation. Mean arterial blood pressure (MAP) was assessed in the last minute of each dose and was used for subsequent calculation of cutaneous vascular conductance (CVC; LDF/MAP) and responses were normalized to each individual site's maximal response (%CVCmax). Group four-parameter dose response curves were compared with an extra sum of squares F-test. SNP EC50 was greater in obese relative to lean (-2.931 +/- 0.10 vs -3.746 +/- 0.18 Log[SNP] M, P < 0.001); however, there was no difference in MCh EC50 between groups (-3.796 +/- 0.23 vs 3.852 +/- 0.25 Log[MCh] M, P = 0.81). Additionally, baseline and maximal CVC in both sites were similar between groups (all P > 0.05). These results suggest attenuated endothelium-independent response to nitric oxide while endothelium-dependent vasodilation function is maintained. (C) 2015 Elsevier Inc. All rights reserved.
C1 [Patik, Jordan C.; Christmas, Kevin M.; Hurr, Chansol; Brothers, R. Matthew] Univ Texas Austin, Dept Kinesiol & Hlth Educ, Environm & Auton Physiol Lab, Austin, TX 78712 USA.
C3 University of Texas System; University of Texas Austin
RP Brothers, RM (corresponding author), Univ Texas Arlington, Dept Kinesiol, Maverick Activ Ctr 155, Box 19259, Arlington, TX 76109 USA.
EM matthew.brothers@uta.edu
RI Patik, Jordan/GXG-7772-2022
OI Patik, Jordan/0000-0002-1463-1335; Hurr, Chansol/0000-0003-4062-7441
FU University of Texas at Austin
FX This research was supported by start-up funds to R. Matthew Brothers
   from The University of Texas at Austin.
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NR 46
TC 22
Z9 23
U1 0
U2 15
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0026-2862
EI 1095-9319
J9 MICROVASC RES
JI Microvasc. Res.
PD MAR
PY 2016
VL 104
BP 63
EP 68
DI 10.1016/j.mvr.2015.11.007
PG 6
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA DA4JN
UT WOS:000367766300008
PM 26631530
DA 2025-06-11
ER

PT J
AU Martin, CA
   Cameron, JD
   Chen, SS
   McGrath, BP
AF Martin, Catherine A.
   Cameron, James D.
   Chen, Suzi S.
   McGrath, Barry P.
TI Two hour glucose post loading: a biomarker of cardiovascular risk in
   isolated clinic hypertension
SO JOURNAL OF HYPERTENSION
LA English
DT Article
DE autonomic function; circulating biomarkers; glucose; insulin resistance;
   isolated clinic hypertension; pulse wave velocity; white-coat
   hypertension
ID WHITE-COAT HYPERTENSION; IMPAIRED FASTING GLUCOSE;
   HEART-RATE-VARIABILITY; LONG-TERM RISK; SUSTAINED HYPERTENSION;
   SYMPATHETIC ACTIVITY; METABOLIC SYNDROME; BLOOD-PRESSURE; ALL-CAUSE;
   POPULATION
AB Background Isolated clinic hypertension (ICHT) may be an indicator of both future hypertension and diabetes. This study examines the 2-h plasma glucose level post load (2hPG), and measures of arterial stiffness, autonomic function and circulating biomarkers in ICHT, normotension and hypertension.
   Methods Participants aged 39-75 years, who were untreated for hypertension, nonsmokers and not known diabetic (n=105) were categorized as normotension, ICHT and hypertension, based on clinic and mean daytime ambulatory blood pressures. Participants had measurements of autonomic function, aorto-femoral pulse wave velocity (PWVc), as well as blood sampling for lipids and potential circulating biomarkers [high sensitivity C-reactive protein (hsCRP), plasminogen activator inhibitor 1 (PAI-1), asymmetric dimethylarginine (ADMA), and von Willebrand factor (vWF)], followed by a glucose tolerance test.
   Results A total of 8.3% normotension, 37.9% ICHT and 15% hypertension patients had impaired glucose tolerance. Mean 2hPG adjusted for age and waist circumference was 5.7 mmol/l [ interquartile range (IQR) 5.2-6.4] for normotension, 7.4 mmol/l (IQR 6.5-8.3) for ICHT (P=0.002 vs. normotension) and 6.2 mmol/l (IQR 5.6-6.9) for hypertension group. Other measures of insulin resistance were similar in the three groups. Mental stress testing induced a greater blood pressure response in the ICHT group (P=0.01 vs. normotension); other autonomic function measures were similar in the three groups. Mean PWVc, adjusted for age and blood pressure, was similar in ICHT and normotension but increased in the hypertension group. Circulating biomarker levels were not different in the three groups.
   Conclusion Assessment of total cardiovascular risk in patients with ICHT should include measurement of postprandial glucose. J Hypertens 29:749-757(C) 2011 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
C1 [Martin, Catherine A.; Chen, Suzi S.; McGrath, Barry P.] Dandenong Hosp, Dept Vasc Sci & Med, Dandenong, Vic, Australia.
   [Martin, Catherine A.; Chen, Suzi S.; McGrath, Barry P.] Monash Univ, Dandenong, Australia.
   [Cameron, James D.] La Trobe Univ, Bundoora, Vic, Australia.
C3 Monash Health; Dandenong Hospital; Monash University; La Trobe
   University
RP McGrath, BP (corresponding author), Dandenong Hosp, Dept Vasc Sci & Med, David St, Dandenong, Vic, Australia.
EM barry.mcgrath@med.monash.edu
RI Cameron, james/GQP-4595-2022
OI Cameron, James/0000-0003-0589-0367
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NR 44
TC 16
Z9 17
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0263-6352
EI 1473-5598
J9 J HYPERTENS
JI J. Hypertens.
PD APR
PY 2011
VL 29
IS 4
BP 749
EP 757
DI 10.1097/HJH.0b013e328342eeeb
PG 9
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 732PH
UT WOS:000288199500019
PM 21192271
DA 2025-06-11
ER

PT J
AU Buscemi, S
   Verga, S
   Tranchina, MR
   Cottone, S
   Cerasola, G
AF Buscemi, S.
   Verga, S.
   Tranchina, M. R.
   Cottone, S.
   Cerasola, G.
TI Effects of hypocaloric very-low-carbohydrate diet vs. Mediterranean diet
   on endothelial function in obese women
SO EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
LA English
DT Article
DE FMD; low-carbohydrate diet; Mediterranean diet; obesity
ID FLOW-MEDIATED DILATATION; LOW-FAT DIET; INSULIN-RESISTANCE; WEIGHT-LOSS;
   CARDIOVASCULAR EVENTS; METABOLIC SYNDROME; HEALTHY HUMANS; RISK-FACTORS;
   DYSFUNCTION; DISEASE
AB Obesity is a cardiovascular risk factor associated with endothelial dysfunction, but the effect of different weight loss strategies on endothelial function is not known. The effect of diet on endothelial function in two hypocaloric diets, a very-low-carbohydrate diet (A) and a Mediterranean diet (M), was measured by brachial artery flow-mediated dilation (FMD).
   Using a longitudinal, randomized, open study design, subjects were engaged in a 2-month weight loss diet. FMD, inflammatory cytokines [interleukin-6 (IL-6) and tumour necrosis factor-alpha] and a marker of oxidative stress [8-iso-prostaglandin F2 alpha (8-iso-PGF2 alpha)] were measured in subjects on three occasions: before initiating the diet (T0), after 5-7 days of dieting (T5) and after 2 months of dieting (T60). The very short- and medium-term time points were established to discriminate respectively the effect of the diet itself (T5) from that of weight loss (T60). Twenty overweight/obese but otherwise healthy women (BMI: 27-34.9 kg m(-2); age 30-50 years) completed the study.
   Group A lost more weight (mean +/- SEM; -7.6 +/- 0.8 kg) than group M (-4.9 +/- 0.6 kg, P = 0.014) at T60. The FMD was not significantly different between the two groups at T0 (group A: 12.2 +/- 2.9% vs. group B: 10.3 +/- 2.3%, P = ns). In group A, FMD was significantly reduced at T5 and returned to baseline at T60; in group M, FMD increased at T5 and returned to baseline at T60 (P = 0.007 for diet x time interaction). Serum concentrations of IL-6 and 8-iso-PGF2 alpha were not significantly different between the two groups at T0 and increased significantly at T5 only in group A (P < 0.001 and P < 0.005 respectively).
   As endothelial dysfunction is known to be associated with acute cardiovascular events, this study suggests that the cardiovascular risk might be increased in the first days of a very-low-carbohydrate diet.
C1 [Buscemi, S.; Verga, S.; Tranchina, M. R.; Cottone, S.; Cerasola, G.] Univ Palermo, Dipartimento Med Interna Malattie Cardiovasc & Ne, Fac Med, Palermo, Italy.
C3 University of Palermo
RP Buscemi, S (corresponding author), Policlin P Giaccone, UO Med Interna Nefrol & Ipertens, Via Vespro 129, I-90127 Palermo, Italy.
EM silbus@tin.it
RI ; buscemi, silvio/K-9662-2016
OI cottone, santina/0000-0001-6226-5846; buscemi,
   silvio/0000-0003-0730-7649; VERGA, Salvatore/0000-0002-7743-7847
FU Italian Ministry of Education [ORPA06JR3L]
FX This study was supported by the Italian Ministry of Education (ex 60%
   funds; ref.: ORPA06JR3L).
CR [Anonymous], Hearing Pertaining to Dr. Atkins's "Diet
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NR 49
TC 73
Z9 76
U1 2
U2 16
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0014-2972
EI 1365-2362
J9 EUR J CLIN INVEST
JI Eur. J. Clin. Invest.
PD MAY
PY 2009
VL 39
IS 5
BP 339
EP 347
DI 10.1111/j.1365-2362.2009.02091.x
PG 9
WC Medicine, General & Internal; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Research & Experimental Medicine
GA 428BF
UT WOS:000264822100001
PM 19302563
DA 2025-06-11
ER

PT J
AU Günday, ÖK
   Erdogan, MÖ
   Pehlivan, A
   Yilmazer, M
AF Gunday, Ozlem Kayacik
   Erdogan, Mujgan Ozdemir
   Pehlivan, Aysen
   Yilmazer, Mehmet
TI The effect of metformin treatment on leukocyte telomere length in
   patients with polycystic ovary syndrome: a prospective case-control
   study
SO JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
LA English
DT Article
DE Telomere; Polycystic ovary syndrome; Metformin; Peripheral blood
   leukocytes
ID C-REACTIVE PROTEIN; INSULIN-RESISTANCE; METABOLIC SYNDROME; SYNDROME
   PCOS; INFLAMMATORY BIOMARKERS; GLUCOSE-TOLERANCE; OXIDATIVE STRESS;
   NORMAL MENSES; DOUBLE-BLIND; ASSOCIATION
AB Purpose The study aimed to investigate the effect of metformin treatment on leukocyte telomere length (LTL) and the relationship of LTL with C-reactive protein (CRP), homocysteine, albumin, complete blood count, and HOMA-IR values in patients with polycystic ovary syndrome (PCOS).
   Material and method A prospective case-control study consisting of 30 women with PCOS and 30 healthy women without PCOS was performed. The relationship between clinical and laboratory parameters and LTL was analyzed. PCOS patients were treated with metformin (850 mg/day) for three months. Before treatment (BT) and after treatment (AT), each patient's LTL was evaluated and compared with the control group.
   Results In the comparison between PCOS and control groups, the difference was significant for LTL, age, body mass index (BMI), and CRP (p = 0.002; p < 0.001; p = 0.001; p = 0.01, respectively). In PCOS patients, the difference between BT and AT, LTL was not statistically significant (BT: 6.06 +/- 2.12; AT: 6.30 +/- 1.93; p = 0.623; 95% C.I: - 1.22-0.74); however, the difference for weight was significant (BT: 83.78 +/- 15.31; AT: 80.62 +/- 15.40; p = 0.02; 95% CI: 1.34-4.99). The logistic regression model established by BMI (group 1: 21-24, group 2: 24-29, group 3: 29-34, group 4: > 34), age, and RDW, which predicted the PCOS group by affecting the LTL level, was statistically significant (p < 0.001/PPV = 96.3%; NPV = 88.5%). Each unit reduction in telomere length increased women's probability of PCOS by 0.4 times (p = 0.013; OR = 0.419, 95% CI: 0.211-0.835).
   Conclusion Although statistically insignificant, LTL increased after metformin use in PCOS patients, and the mean weight loss reduction was statistically significant. Telomere shortening increased the likelihood of PCOS 0.4 times.
C1 [Gunday, Ozlem Kayacik; Yilmazer, Mehmet] Afyonkarahisar Univ Hlth Sci, Fac Med, Dept Obstet & Gynecol, Afyon, Turkey.
   [Erdogan, Mujgan Ozdemir; Pehlivan, Aysen] Afyonkarahisar Univ Hlth Sci, Fac Med, Dept Genet, Afyon, Turkey.
C3 Afyonkarahisar Health Sciences University; Afyonkarahisar Health
   Sciences University
RP Günday, ÖK (corresponding author), Afyonkarahisar Univ Hlth Sci, Fac Med, Dept Obstet & Gynecol, Afyon, Turkey.
EM kayacikozlem@yahoo.com.tr; mozdemir1977@gmail.com;
   aysen.27.06@hotmail.com; drmehmetyilmazer@yahoo.com
RI KAYACIK GUNDAY, Özlem/ABP-5662-2022; PEHLIVAN, AYSEN/JCE-7308-2023
OI PEHLIVAN, AYSEN/0000-0001-9805-4223
FU Afyonkarahisar Health Sciences University Scientific Research Projects
   Unit [20.011]
FX This study was supported by Afyonkarahisar Health Sciences University
   Scientific Research Projects Unit (project no: 20.011).
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NR 61
TC 3
Z9 3
U1 4
U2 6
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1058-0468
EI 1573-7330
J9 J ASSIST REPROD GEN
JI J. Assist. Reprod. Genet.
PD SEP
PY 2022
VL 39
IS 9
BP 2153
EP 2161
DI 10.1007/s10815-022-02577-y
EA JUL 2022
PG 9
WC Genetics & Heredity; Obstetrics & Gynecology; Reproductive Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Genetics & Heredity; Obstetrics & Gynecology; Reproductive Biology
GA 4O7YL
UT WOS:000829768000001
PM 35861921
OA Green Published
DA 2025-06-11
ER

PT J
AU Kou, HJ
   Deng, J
   Gao, DF
   Song, AQ
   Han, ZH
   Wei, J
   Jin, X
   Ma, R
   Zheng, QS
AF Kou, Huijuan
   Deng, Jie
   Gao, Dengfeng
   Song, Anqi
   Han, Zhenhua
   Wei, Jin
   Jin, Xin
   Ma, Rui
   Zheng, Qiangsun
TI Relationship among adiponectin, insulin resistance and atherosclerosis
   in non-diabetic hypertensive patients and healthy adults
SO CLINICAL AND EXPERIMENTAL HYPERTENSION
LA English
DT Article
DE Adiponectin; Insulin resistance; atherosclerosis; hypertension; HOMA-IR;
   AIP
ID DENSITY-LIPOPROTEIN-CHOLESTEROL; MOLECULAR-WEIGHT ADIPONECTIN; OXIDATIVE
   STRESS; METABOLIC SYNDROME; ATHEROGENIC INDEX; PLASMA; RISK;
   ASSOCIATION; PROTEIN; PREDICTOR
AB Adiponectin, which is secreted specifically by adipose tissue, has been shown to have anti-atherogenic and anti-inflammatory effects and to improve insulin resistance (IR). The aim of this study was to determine the correlations among adiponectin, IR and atherosclerosis in non-diabetic hypertensive patients and healthy volunteers. In this case control study, we collected complete demographic data from and measured several laboratory parameters in all enrolled subjects. The homeostasis model of assessment for insulin resistance (HOMA-IR) was calculated as an insulin sensitivity index. The atherogenic index of plasma (AIP), which is calculated as log (triglyceride (TG)/high-density lipoprotein cholesterol (HDL-C)), was a significant predictor of atherosclerosis and was a better predictor of atherosclerosis than low-density lipoprotein cholesterol (LDL-C). Plasma adiponectin, interleukin (IL)-6, monocyte chemoattractant protein-1 (MCP-1) and matrix metalloprotein-9 (MMP-9) concentrations were determined using enzyme-linked immunosorbent assay (ELISA). All data were analyzed using Statistical Product and Service Solutions for Windows (SPSS) 13.0 software. A total of 309 participants were enrolled in the study. Hypertensive patients with IR (n = 93) displayed significantly higher HOMA-IR values and AIPs and lower adiponectin levels than hypertensive patients without IR (n = 121) and healthy adults (n = 95) (P < 0.05). Furthermore, circulating IL-6, MCP-1 and MMP-9 concentrations differed significantly between hypertensive patients and healthy adults (P < 0.05). Additionally, adiponectin levels were found to be inversely correlated with IL-6, MCP-1, and MMP-9 levels; HOMA-IR values; and AIPs in the clinical study. HOMA-IR values and adiponectin and creatinine (Cr) concentrations remained independently associated with AIPs in all participants after adjustment for confounders via multivariate linear regression. Low adiponectin levels are positively correlated with decreased insulin sensitivity, increased pro-inflammatory cytokine production and worsening atherosclerosis in hypertensive patients and healthy adults.
C1 [Kou, Huijuan; Deng, Jie; Gao, Dengfeng; Song, Anqi; Han, Zhenhua; Wei, Jin; Ma, Rui; Zheng, Qiangsun] Xi An Jiao Tong Univ, Affiliated Hosp 2, Dept Cardiol, Xian 710004, Shaanxi, Peoples R China.
   [Jin, Xin] Xi An Jiao Tong Univ, Affiliated Hosp 2, Dept Ultrasonog, Xian, Shaanxi, Peoples R China.
C3 Xi'an Jiaotong University; Xi'an Jiaotong University
RP Kou, HJ; Zheng, QS (corresponding author), Xi An Jiao Tong Univ, Affiliated Hosp 2, Dept Cardiol, Xian 710004, Shaanxi, Peoples R China.
EM khjsarah@163.com; zhengqs@mail.xjtu.edu.cn
RI Jin, Xin/ABF-1329-2020
FU Fundamental Research Funds for the Central Universities
   [0817-1191320079]; Second Affiliated Hospital of Xi'an Jiaotong
   University [RC-XM-201608, YJ-QN-201419]
FX This study was supported by the Fundamental Research Funds for the
   Central Universities (NO: 0817-1191320079) and the Research Project of
   the Second Affiliated Hospital of Xi'an Jiaotong University (NO:
   RC-XM-201608 and NO: YJ-QN-201419).
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NR 39
TC 25
Z9 25
U1 1
U2 9
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1064-1963
EI 1525-6006
J9 CLIN EXP HYPERTENS
JI Clin. Exp. Hypertens.
PY 2018
VL 40
IS 7
BP 656
EP 663
DI 10.1080/10641963.2018.1425414
PG 8
WC Pharmacology & Pharmacy; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Cardiovascular System & Cardiology
GA GS7BC
UT WOS:000443853300010
PM 29336612
DA 2025-06-11
ER

PT J
AU Zhang, HL
   Liu, S
   Li, L
   Liu, SS
   Liu, SQ
   Mi, J
   Tian, G
AF Zhang, Haili
   Liu, Shuang
   Li, Lan
   Liu, Shisong
   Liu, Shuqi
   Mi, Jia
   Tian, Geng
TI The impact of grape seed extract treatment on blood pressure changes A
   meta-analysis of 16 randomized controlled trials
SO MEDICINE
LA English
DT Article
DE diastolic blood pressure; grape seed extract; meta-analysis; randomized
   controlled trial; systolic blood pressure
ID OXIDATIVE STRESS; DOUBLE-BLIND; ESSENTIAL-HYPERTENSION; ENDOTHELIAL
   FUNCTION; RED WINE; POLYPHENOLS; JUICE; PARAMETERS; OBESITY; MEN
AB Backgrounds and Objective: Several clinical trials have shown that grape seed extract can reduce blood pressure, but the results are often irreproducible. We therefore sought to systematically evaluate the impact of grape seed extract treatment on the changes of systolic/diastolic blood pressure (SBP/DBP) by meta-analyzing available randomized controlled trials.
   Methods: Trial selection and data extraction were completed independently by 2 investigators. Effect-size estimates were expressed as weighted mean difference (WMD) and 95% confidence interval (CI).
   Results: Twelve articles involving 16 clinical trials and 810 study subjects were analyzed. Overall analyses found significant reductions for SBP (WMD=-6.077; 95% CI: -10.736 to -1.419; P=0.011) and DBP (WMD=-2.803; 95% CI: -4.417 to -1.189; P=0.001) after grape seed extract treatment. In subgroup analyses, there were significant reductions in younger subjects (mean age <50 years) for SBP (WMD=-6.049; 95% CI: -10.223 to -1.875; P=0.005) and DBP (WMD=-3.116; 95% CI: -4.773 to -1.459; P<0.001), in obese subjects (mean body mass index >= 25kg/m(2)) for SBP (WMD=-4.469; 95% CI: -6.628 to -2.310; P<0.001), and in patients with metabolic syndrome for SBP (WMD=-8.487; 95% CI: -11.869 to -5.106; P<0.001). Further meta-regression analyses showed that age, body mass index, and baseline blood pressure were negatively associated with the significant reductions of SBP and DBP after treatment. There was no indication of publication bias.
   Conclusion: Our findings demonstrate that grape seed extract exerted a beneficial impact on blood pressure, and this impact was more obvious in younger or obese subjects, as well as in patients with metabolic disorders. In view of the small sample size involved, we agree that confirmation of our findings in a large-scale, long-term, multiple-dose randomized controlled trial, especially among hypertensive patients is warranted.
C1 [Zhang, Haili] Binzhou Med Univ, Coll Pharm, Yantai, Shandong, Peoples R China.
   [Liu, Shuang; Li, Lan; Liu, Shisong; Liu, Shuqi] Binzhou Med Univ, Sch Enol, Yantai, Shandong, Peoples R China.
   [Mi, Jia; Tian, Geng] Binzhou Med Univ, Med & Pharm Res Ctr, Yantai, Shandong, Peoples R China.
C3 Binzhou Medical University; Binzhou Medical University; Binzhou Medical
   University
RP Liu, SQ; Mi, J; Tian, G (corresponding author), Guanhai Rd 346, Yantai 264003, Shandong, Peoples R China.
EM zhangshuqisd@sohu.com; mimi_mj@yeah.net; tiangengshandong@yeah.net
RI Zhang, Haili/JTT-7717-2023
FU National Natural Science Foundation of China [81400771]; Natural Science
   Foundation of Shandong Province [ZR2014HL028, ZR2015PH043, ZR2015HL040];
   Technology Project for the Universities of Shandong Province [J14LE01];
   Binzhou Medical University Scientific Research Funds [BY2013KYQD18,
   BY2013KYQD17, BY2013KJ62]; Science and Technology Key Project of Binzhou
   Medical University [BY2012KJZD08]
FX This work was supported by the National Natural Science Foundation of
   China (81400771), the Natural Science Foundation of Shandong Province
   (ZR2014HL028, ZR2015PH043, and ZR2015HL040), the Technology Project for
   the Universities of Shandong Province (J14LE01), the Binzhou Medical
   University Scientific Research Funds (BY2013KYQD18, BY2013KYQD17, and
   BY2013KJ62), and the Science and Technology Key Project of Binzhou
   Medical University (BY2012KJZD08).
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NR 28
TC 32
Z9 33
U1 2
U2 10
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD AUG
PY 2016
VL 95
IS 33
AR e4247
DI 10.1097/MD.0000000000004247
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA DU5KR
UT WOS:000382251100006
PM 27537554
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Du, JH
   Li, R
   Xu, L
   Ma, RR
   Liu, JL
   Cheng, J
   Zhang, Z
   Sun, HZ
AF Du, Junhui
   Li, Rong
   Xu, Lin
   Ma, Ranran
   Liu, Jiali
   Cheng, Jing
   Zhang, Zhong
   Sun, Hongzhi
TI Increased Serum Chemerin Levels in Diabetic Retinopathy of Type 2
   Diabetic Patients
SO CURRENT EYE RESEARCH
LA English
DT Article
DE Chemerin; diabetic retinopathy; retinopathy; vascularization; VEGF
ID METABOLIC SYNDROME; ENDOTHELIAL-CELLS; OXIDATIVE STRESS; MACULAR EDEMA;
   LIPID LEVELS; INFLAMMATION; DISEASE; OBESITY; ADIPOGENESIS; POPULATION
AB Purpose: To compare serum levels of chemerin in type 2 diabetes mellitus (T2DM) with or without retinopathy, and to investigate the relationship between serum chemerin levels and diabetes retinopathy.
   Materials and methods: A total of 60 T2DM patients and 20 healthy subjects (control group) were enrolled in this study. Of the T2DM patients, 15 had proliferative diabetic retinopathy (PDR group), 20 had non-proliferative retinopathy (NPDR group) and 25 had no retinopathy (T2DM group). Their serum samples were collected for testing the levels of chemerin, vascular endothelial growth factor (VEGF), C-reactive protein (CRP) and so on. The values were analyzed to compare the differences among the groups. Simple linear regression analysis and multiple stepwise linear regression analysis were used to determine the correlations between variables and chemerin. Trend chi-square was used to determine the correlations between chemerin and the severity of diabetic retinopathy (DR).
   Results: Chemerin levels in group PDR, NPDR and no DR were 147.5635.98g/l, 128.09 +/- 16.33g/l and 113.19 +/- 19.89g/l, with the significant difference across the three groups (p<0.05). But there was no difference between control group (109.55 +/- 20.98g/l) and T2DM group. Simple linear regression show that serum chemerin was correlated with duration of diabetes, body mass index (BMI), serum triglycerides, total-cholesterol, CRP and VEGF, and not correlated with age, systolic and diastolic blood pressure in T2DM patients. Stepwise regression analysis showed that BMI, CRP and VEGF were significantly associated with serum chemerin (p=0.006, p=0.011 and p=0.036, respectively). In addition, the more severity of DR as the chemerin levels increased ((2)=16.07, p<0.001).
   Conclusions: Serum levels of chemerin were significantly increased in the NPDR and PDR group. Elevated serum level of chemerin and its positive correlation with BMI, CRP and VEGF suggested that chemerin was associated with obesity, inflammation and neovascularization and might be involved in the development of DR.
C1 [Du, Junhui; Ma, Ranran; Liu, Jiali; Sun, Hongzhi] Xi An Jiao Tong Univ, Sch Med, Minist Educ, Key Lab Environm & Genes Related Dis, Xian 710061, Shaanxi, Peoples R China.
   [Du, Junhui; Cheng, Jing; Zhang, Zhong] Xi An Jiao Tong Univ, Coll Med, Xian Hosp 9, Dept Ophthalmol, Xian 710061, Shaanxi, Peoples R China.
   [Li, Rong] Xian Med Univ, Affiliated Hosp, Dept Ophthalmol, Xian, Shaanxi, Peoples R China.
   [Xu, Lin] Xi An Jiao Tong Univ, Coll Med, Affiliated Guangren Hosp, Dept Endocrinol, Xian, Shaanxi, Peoples R China.
C3 Ministry of Education - China; Xi'an Jiaotong University; Xi'an Jiaotong
   University; Xi'an Medical University; Xi'an Jiaotong University
RP Sun, HZ (corresponding author), Xi An Jiao Tong Univ, Sch Med, Minist Educ, Key Lab Environm & Genes Related Dis, Xian 710061, Shaanxi, Peoples R China.
EM sunhongzhi@mail.xjtu.edu.cn
RI Du, junhui/P-3183-2019; Li, Rong/AAW-7730-2020
OI Du, junhui/0000-0001-6692-3877
FU National Natural Science Foundation of China [30971392, 81170741]
FX This work was supported by grants from the National Natural Science
   Foundation of China (General Program no. 30971392 and 81170741).
CR Abu El-Asrar AM, 2006, EUR CYTOKINE NETW, V17, P155, DOI 10.1684/ecn.2006.0033
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NR 45
TC 20
Z9 24
U1 0
U2 13
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 0271-3683
EI 1460-2202
J9 CURR EYE RES
JI Curr. Eye Res.
PD JAN 2
PY 2016
VL 41
IS 1
BP 114
EP 120
DI 10.3109/02713683.2015.1004718
PG 7
WC Ophthalmology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Ophthalmology
GA DA1BE
UT WOS:000367530500015
PM 25848840
DA 2025-06-11
ER

PT J
AU Koshy, SM
   Bobby, Z
   Hariharan, AP
   Gopalakrishna, SM
AF Koshy, Smitha M.
   Bobby, Zachariah
   Hariharan, Ananthanarayanan P.
   Gopalakrishna, Sridhar M.
TI Amla (Emblica officinalis) extract is effective in preventing
   high fructose diet-induced insulin resistance and atherogenic
   dyslipidemic profile in ovariectomized female albino rats
SO MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY
LA English
DT Article
DE Atherogenic dyslipidemia; Amla; Fructose; Menopause; Ovariectomy
ID DENSITY-LIPOPROTEIN CHOLESTEROL; CORONARY-HEART-DISEASE; SPONTANEOUSLY
   HYPERTENSIVE-RATS; ELLAGIC ACID; CARDIOVASCULAR-DISEASE; POSTMENOPAUSAL
   WOMEN; OXIDATIVE STRESS; MYOCARDIAL-INFARCTION; PHYLLANTHUS-EMBLICA;
   METABOLIC SYNDROME
AB Objective: The aim of this study was to evaluate the effect of ovarian hormone withdrawal and a high fructose diet on the development of atherogenic dyslipidemia in rats. Because amla (Indian gooseberry) is known to possess hypolipidemic properties, its preventive effect on the above was also studied.
   Methods: Three-month-old female albino rats were either ovariectomized (n = 48) or sham-operated (n = 12). The study was performed in two phases: phase 1 (first 12 wk) and phase 2 (next 6 wk). The sham-operated rats were fed rodent chow in both phases (control). The ovariectomized rats were assigned to four groups: rats fed chow in both phases (O), rats fed a 60% fructose-rich diet in phase 2 alone (O + F), rats administered chow and amla extract in both phases (O + A), and rats administered chow + amla extract in phase 1 and then fed a 60% fructose-rich diet + amla extract in phase 2 (O + F + A).
   Results: O + F rats developed insulin resistance and had increased triglycerides (TGs) and total cholesterol. O + A and O + F + A groups had significantly lower low-density lipoprotein cholesterol and higher high-density lipoprotein (HDL) cholesterol compared with controls. O + F + A did not develop insulin resistance and had reduced TGs compared with O + F rats. O + A and O + F + A rats showed a tremendous decrease in non-HDL cholesterol and non-HDL cholesterol/HDL cholesterol, TG/HDL cholesterol, and total cholesterol/HDL cholesterol ratios.
   Conclusions: Amla decreased low-density lipoprotein cholesterol and increased HDL cholesterol in ovariectomized rats fed chow or fructose. In ovariectomized and fructose-fed rats, it prevented insulin resistance aside from subduing the rise in TG. Amla may be explored for its use in preventing dyslipidemia in postmenopausal women.
C1 [Koshy, Smitha M.; Bobby, Zachariah; Hariharan, Ananthanarayanan P.; Gopalakrishna, Sridhar M.] Jawaharlal Inst Postgrad Med Educ & Res, Dept Biochem, Pondicherry 605006, India.
C3 Jawaharlal Institute of Postgraduate Medical Education & Research
RP Bobby, Z (corresponding author), Jawaharlal Inst Postgrad Med Educ & Res, Dept Biochem, Pondicherry 605006, India.
EM zacbobby@yahoo.com
RI Zachariah, Bobby/IUQ-0806-2023
FU Indian Council of Medical Research, New Delhi
FX This work was supported by the institutional intramural research grant
   in favor of the corresponding author (Z.B.). It was also supported by
   the Indian Council of Medical Research, New Delhi, toward research
   fellowships to the first author (S.M.K.).
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NR 95
TC 16
Z9 18
U1 0
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1072-3714
EI 1530-0374
J9 MENOPAUSE
JI Menopause-J. N. Am. Menopause Soc.
PD OCT
PY 2012
VL 19
IS 10
BP 1146
EP 1155
DI 10.1097/gme.0b013e31824e5bf7
PG 10
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA 016ZQ
UT WOS:000309558800017
PM 22692334
DA 2025-06-11
ER

PT J
AU Liu, JL
   Han, LN
   Zhu, LL
   Yu, YR
AF Liu, Jiali
   Han, Lina
   Zhu, Leilei
   Yu, Yerong
TI Free fatty acids, not triglycerides, are associated with non-alcoholic
   liver injury progression in high fat diet induced obese rats
SO LIPIDS IN HEALTH AND DISEASE
LA English
DT Article
DE Non-alcoholic fatty liver disease; Free fatty acids; Triglycerides;
   Oxidative stress; Lipid metabolism
ID HEPATIC STEATOSIS; STEATOHEPATITIS; PATHOGENESIS; RESISTANCE; PROTECTS;
   DISEASE; MODELS; HEART; MICE
AB Background: The incidence of non-alcoholic fatty liver disease (NAFLD), commonly associated with obesity and metabolic syndrome, is increasing worldwide. However, the specific mechanisms that mediate the progression from simple steatosis to non-alcoholic steatohepatitis remain largely unclear. This study aimed to investigate the timedependent changes of triglyceride (TG) and free fatty acid (FFA) levels in the blood and liver over 24 weeks in high-fat diet-induced obese rats with NAFLD and to clarify the role of high FFA levels in the progression of liver injury.
   Methods: Male Wistar rats were randomly divided into three groups (n = 30 per group): the Control group, fed standard chow; the High-fat diet (HFD) group, fed high-fat chow; and the Acipimox group, fed an HFD plus acipimox (100 mg/kg/d, ig) for 8, 16 and 24 weeks. After treatment, blood and liver samples were collected for biochemical analyses, western blotting analysis and a histopathological study.
   Results: The visceral fat/weight and liver/body weight ratios were higher in both the HFD and Acipimox groups than in the Control group. The TG and FFA concentrations in blood and liver were increased in the HFD group and associated with elevated serum alanine aminotransferase (ALT) and liver malondialdehyde (MDA) levels and macro/microvesicular steatosis on hepatic fragments. Although the TG levels in the liver were similar between the HFD and Acipimox groups (p > 0.05), the FFA concentrations in the blood and liver were much lower in the latter group (p < 0.05). The Acipimox group showed normal ALT and MDA levels as well as less severe hepatic histological changes than did the HFD group (NAFLD activity score: 2.14 +/- 0.14, 2.43 +/- 0.20 and 2.63 +/- 0.26 at 8, 16 and 24 weeks, respectively; p < 0.05 versus the HFD group at 24 weeks). The diacylglycerol acyltransferase 2 (DGAT2) protein levels were similar between the HFD and Acipimox groups (p > 0.05), but the protein expression level of carnitine palmitoyltransferase 1a (CPT-1a) was higher in the Acipimox group.
   Conclusions: Liver TG accumulation does not cause cellular injury in the liver; rather, FFAs or their metabolites are responsible for liver injury via increased oxidative stress. It is suggested that the therapeutic efforts to prevent nonalcoholic liver injury progression should be focused on reducing the burden of fatty acids transported to the liver or those being synthesized in the liver.
C1 [Liu, Jiali; Han, Lina; Zhu, Leilei; Yu, Yerong] Sichuan Univ, West China Hosp, Dept Endocrinol & Metab, Guoxue Lane 37, Chengdu 610041, Sichuan, Peoples R China.
C3 Sichuan University
RP Yu, YR (corresponding author), Sichuan Univ, West China Hosp, Dept Endocrinol & Metab, Guoxue Lane 37, Chengdu 610041, Sichuan, Peoples R China.
EM yerongyu@scu.edu.cn
RI Han, Lina/ABG-9162-2020; yu, ye/KVB-7532-2024
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NR 26
TC 107
Z9 123
U1 1
U2 19
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1476-511X
J9 LIPIDS HEALTH DIS
JI Lipids Health Dis.
PD FEB 11
PY 2016
VL 15
AR 27
DI 10.1186/s12944-016-0194-7
PG 9
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA DE2QN
UT WOS:000370471900001
PM 26868515
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Puig, L
   Belloso, RI
   Rivera-Díaz, R
   Sánchez, JM
   Fernández-Freire, LR
   Sahuquillo-Torralba, A
   Ruiz-Villaverde, R
   IMPULSE Investigators Grp
AF Puig, Lluis
   Belloso, Rosa Izu
   Rivera-Diaz, Raquel
   Sanchez, Jordi Mollet
   Fernandez-Freire, Lourdes Rodriguez
   Sahuquillo-Torralba, Antonio
   Ruiz-Villaverde, Ricardo
   IMPULSE Investigators Grp
TI A Non-Interventional, Multicenter Study to Characterize the
   Socio-Demographics, Clinical Characteristics, and Management of
   Generalized Pustular Psoriasis Patients in Spain: IMPULSE Study
SO DERMATOLOGY
LA English
DT Article
DE Generalized pustular psoriasis; Biologic treatment; Spesolimab; Disease
   management
ID RISK-FACTORS; CONSENSUS DOCUMENT; METABOLIC SYNDROME; SPANISH ACADEMY;
   DISEASE; DERMATOLOGY; SPESOLIMAB; INDUCTION; PREGNANCY; JOHOR
AB Introduction: Generalized pustular psoriasis (GPP) is a chronic, rare, and potentially life-threatening skin condition characterized by flares comprising widespread sterile pustules and systemic inflammation. Both the rarity and heterogeneity of the disease have made GPP classification and standardization of clinical criteria challenging. Before the approval of spesolimab (IL-36R antibody) in 2022, there were no approved treatments in the USA or Europe for GPP flares. Treatment for GPP has amounted to off-label use of medicines approved to treat plaque psoriasis. Our aim was to describe the sociodemographics, clinical characteristics, and treatment patterns of patients with GPP in Spain. Methods: Non-interventional, descriptive, multi-center, retrospective chart review of patients diagnosed with GPP in Spain. Results: 56 patients (50% women) were included, with a mean (standard deviation, SD) age at diagnosis of 53.7 (20.5) and a mean (SD) time of follow-up of 3.7 (3.1) years. In 80% of patients, GPP diagnosis was associated with a fl are and 67.3% had known risk factors for GPP (such as previous diagnosis or family history of plaque psoriasis, comorbidities, smoking or stress). Hypertension and plaque psoriasis were the most frequent comorbidities (44.6% each). The number of GPP flares per patient-year was 0.55 with (range 0-4) a mean (SD) body surface area involvement of 21.3% (19.1). The most frequent manifestations of GPP flares were pustules (88.5%), erythema (76.9%), and scaling (76.9%). Additionally, 65.4% of patients had plaque psoriasis, 53.8% had unspecified skin lesions, and 30.8% experienced pain. The treatments used for GPP flares were off-label conventional systemic drugs (75%), mostly corticosteroids, cyclosporine, and acitretin. In the periods between flares, off-label biologics were used in 56.5% of patients. During the study period, 9 patients (16.1%) had at least one complication and 5 of them required hospitalization. Conclusion: This is the first multicenter study in Spanish GPP patients. Most patients were in their fifties, with personal or family history of plaque psoriasis, stress, smoking and a wide range of co- morbidities and complications. Even though the number of fl ares per patient/year was 0.55, there was variability between patients. Both off-label conventional systemics and off-label biologics were used for fl are management without a clear treatment pattern. (c) 2024 The Author(s). Published by S. Karger AG, Basel
C1 [Puig, Lluis] Hosp Santa Creu & Sant Pau, Dermatol Dept, Barcelona, Spain.
   [Belloso, Rosa Izu] Hosp Univ Basurto, Dermatol Dept, Bilbao, Spain.
   [Rivera-Diaz, Raquel] Hosp Univ 12 Octubre, Dermatol Dept, Madrid, Spain.
   [Sanchez, Jordi Mollet] Hosp Univ Vall dHebron, Dermatol Dept, Barcelona, Spain.
   [Fernandez-Freire, Lourdes Rodriguez] Hosp Univ Virgen Rocio, Dermatol Dept, Seville, Spain.
   [Sahuquillo-Torralba, Antonio] Hosp Univ & Politecn La Fe, Dermatol Dept, Valencia, Spain.
   [Ruiz-Villaverde, Ricardo] Hosp Univ Clin San Cecilio, Dermatol Dept, Granada, Spain.
C3 Hospital of Santa Creu i Sant Pau; Basurto Hospital; Hospital
   Universitario 12 de Octubre; Hospital Universitari Vall d'Hebron; Virgen
   del Rocio University Hospital; Hospital Universitari i Politecnic La Fe
RP Puig, L (corresponding author), Hosp Santa Creu & Sant Pau, Dermatol Dept, Barcelona, Spain.
EM lpuig@santpau.cat
RI Rivera Díaz, Raquel/HHN-1810-2022; Ruiz-Villaverde, Ricardo/F-5007-2016
OI Ruiz-Villaverde, Ricardo/0000-0002-0381-6174
FU Boehringer Ingelheim (BI) Spain
FX The study was promoted and funded by Boehringer Ingelheim (BI) Spain. BI
   was given the opportunity to review the manuscript for medical and
   scientific accuracy as well as intellectual property considerations.
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NR 66
TC 0
Z9 0
U1 0
U2 1
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1018-8665
EI 1421-9832
J9 DERMATOLOGY
JI Dermatology
PD SEP
PY 2024
VL 240
IS 5-6
BP 778
EP 792
DI 10.1159/000540019
PG 15
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA O7Y8E
UT WOS:001373244100001
PM 39019021
OA hybrid
DA 2025-06-11
ER

PT J
AU Roh, H
   Park, J
   Kim, A
   Kim, N
   Lee, Y
   Kim, BS
   Vijayan, J
   Lee, MK
   Park, CI
   Kim, D
AF Roh, HyeongJin
   Park, Jiyeon
   Kim, Ahran
   Kim, Nameun
   Lee, Yoonhang
   Kim, Bo Seong
   Vijayan, Jasna
   Lee, Mu Kun
   Park, Chan-Il
   Kim, Do-Hyung
TI Overfeeding-Induced Obesity Could Cause Potential Immuno-Physiological
   Disorders in Rainbow Trout (Oncorhynchus mykiss)
SO ANIMALS
LA English
DT Article
DE overfeeding-induced obesity; OxLDL; immune disorder; rainbow trout;
   apoptosis; nutritional disease
ID FREE FATTY-ACIDS; ADIPOSE-TISSUE; INSULIN-RESISTANCE; METABOLIC
   SYNDROME; T-LYMPHOCYTES; LIVER; INFLAMMATION; EXPRESSION; MACROPHAGES;
   APOPTOSIS
AB Simple Summary In this study, we have successfully generated overfeeding-induced obesity in rainbow trout and demonstrated that the overfeeding regime causes adverse effects on the health status of fish. What we found in this study is that fish in the overfed group harbor enlarged liver and macrophages due to high lipid accumulation. The expression of IL-10, CD36, TLR2, and HSP70 (stress and/or obesity-related genes) was significantly upregulated in overfed fish. Moreover, oxidized low-density lipoprotein (OxLDL), which is known to be produced more in obese individuals, caused apoptosis of trout lymphocyte. These results clearly indicate that overfeeding-induced obesity can be the source of stress and cause immuno-physiological disorders in rainbow trout. Awareness and knowledge of farmers on the relationship between overfeeding and fish health might contribute to increased disease resistance and aquaculture production. Although over-nutrition from overfeeding-induced obesity is known to be highly associated with metabolic and immunological disorders in humans, little is known about overfeeding-induced obesity in fish farming. The purpose of this study was to investigate changes in immuno-physiological parameters, to better understand the potential risk of overfeeding-induced obesity in fish. Commercial feed was provided to fish in the overfed group until they refuse to eat, but fish in the control group was fed with the feed at 1% bodyweight per day. The hemato-serological, histological, and immunological changes were observed at weeks 2 and 8. Rainbow trout leukocytes were co-incubated with oxidized low-density lipoprotein (OxLDL), and the phagocytes engulfing the OxLDL and the presence of apoptotic cells were evaluated. The body weight, body mass index (BMI), and hepatosomatic index (HSI) index were significantly higher in the overfed group, and high lipid accumulation and fatty changes were also observed in their livers, indicating that the feeding regime used in this study led to overfeeding-induced obesity. Likewise, much higher numbers of and larger vacuoles were observed in overfed fish macrophages, showing unclear boundaries between the cytoplasm and extracellular space. In the overfed group, the expression of IL-10, HSP70, TLR2, and CD36 was significantly higher, and lymphocyte apoptosis was more evident, indicating that overfeeding-induced obese fish might have immunologic disorders. This was the first study to demonstrate that overfeeding-induced obesity could cause an immune-physiological imbalance in rainbow trout, making them more vulnerable to infectious diseases and various stressful conditions. This study will contribute to improvements in fish nutrition, feeding practices, fish nutrition, and disease prevention in the aquaculture industry.
C1 [Roh, HyeongJin; Park, Jiyeon; Kim, Ahran; Kim, Nameun; Lee, Yoonhang; Vijayan, Jasna; Kim, Do-Hyung] Pukyong Natl Univ, Dept Aquat Life Med, Coll Fisheries Sci, Busan 48513, South Korea.
   [Kim, Ahran] Pusan Natl Univ, Chem Inst Funct Mat, Dept Chem, Ctr Proteome Biophys, Busan 46241, South Korea.
   [Kim, Bo Seong] Natl Inst Fisheries Sci NIFS, Aquat Dis Control Div, Busan 46083, South Korea.
   [Lee, Mu Kun] Korean Aquat Organism Dis Inspector Assoc, Busan 46008, South Korea.
   [Park, Chan-Il] Gyeongsang Natl Univ, Dept Marine Biol & Aquaculture, Coll Marine Sci, Tongyeong 53064, South Korea.
C3 Pukyong National University; Pusan National University; National
   Institute of Fisheries Science; Gyeongsang National University
RP Kim, D (corresponding author), Pukyong Natl Univ, Dept Aquat Life Med, Coll Fisheries Sci, Busan 48513, South Korea.; Park, CI (corresponding author), Gyeongsang Natl Univ, Dept Marine Biol & Aquaculture, Coll Marine Sci, Tongyeong 53064, South Korea.
EM hjroh@pukyong.ac.kr; jiyeon1388@naver.com; ahran110@naver.com;
   skansl123@naver.com; dldbsgkd07@naver.com; fishpath@korea.kr;
   jasnavijayan@gmail.com; leemukun@naver.com; vinus96@hanmail.net;
   dhkim@pknu.ac.kr
RI Roh, HyeongJin/IUN-5479-2023; Park, Chan Il/MGV-3811-2025
OI vijayan, jasna/0000-0002-9528-9622; Roh, HyeongJin/0000-0002-1825-2375
FU Ministry of Oceans and Fisheries, Korea [20150592]
FX Ministry of Oceans and Fisheries, Korea (20150592).
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NR 69
TC 21
Z9 22
U1 0
U2 14
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 2076-2615
J9 ANIMALS-BASEL
JI Animals
PD SEP
PY 2020
VL 10
IS 9
AR 1499
DI 10.3390/ani10091499
PG 15
WC Agriculture, Dairy & Animal Science; Veterinary Sciences; Zoology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture; Veterinary Sciences; Zoology
GA OD6CV
UT WOS:000579940500001
PM 32854279
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Li, RX
   Li, WK
   Xie, JY
   Liu, ZX
   Xiao, Y
   Tocher, DR
   Chen, CY
   Lin, F
   Liu, XJ
   Xie, DZ
   Hong, YC
   Wang, SQ
AF Li, Ruixin
   Li, Wenkai
   Xie, Jiaying
   Liu, Zhixiao
   Xiao, Yi
   Tocher, Douglas R.
   Chen, Cuiying
   Lin, Fan
   Liu, Xiaojuan
   Xie, Dizhi
   Hong, Yucong
   Wang, Shuqi
TI Porphyra Polysaccharides Alleviated High-Carbohydrate
   Diet-Induced Growth Retardation, Lipid Deposition, Impairment of Immune
   and Antioxidant Functions, and Intestinal Morphology in Rabbitfish
   (Siganus canaliculatus)
SO AQUACULTURE NUTRITION
LA English
DT Article
DE antioxidant capacity; gut microbiota; lipid metabolism;
   Porphyra polysaccharides
ID OXIDATIVE STRESS; GENE-EXPRESSION; PERFORMANCE; METABOLISM; EXTRACT;
   MICROBIOTA; APOPTOSIS; MEAL; FISH
AB Porphyra polysaccharide (PPS), derived from marine red seaweeds of the Porphyra genus, has been reported to improve growth performance, lipid metabolism, and antioxidant capability in animals. The present study investigated the effects of PPS supplementation to a high-carbohydrate diet on growth performance, lipid metabolism, immunity, antioxidant capacity, intestinal morphology, and microbial composition in rabbitfish (Siganus canaliculatus). Rabbitfish were fed a basal starch diet (BSD, 15% starch) and high-starch diets (HSD, 25% starch) supplemented with varying levels of PPS (0%, 1.25%, 2.5%, and 5%) for 8 weeks. The results showed that HSD intake significantly decreased body weight and increased hepatosomatic index compared to rabbitfish fed BSD. But all dietary levels of PPS reversed these two indicators of fish fed HSD. In addition, the supplementation of 2.5% and 5% PPS significantly reduced the higher lipid contents in whole fish and abdominal muscle of fish fed HSD. Notably, 2.5% PPS reduced lipid droplets in the liver, possibly through the downregulation of genes associated with lipid synthesis and the upregulation of genes associated with lipid catabolism. Moreover, all levels of PPS supplementation decreased the higher serum alanine aminotransferase activity in fish fed HSD, indicating the alleviation of HSD-induced liver impairment. Additionally, PPS inclusion significantly increased the activity of serum lysozyme, superoxide dismutase, and catalase while decreasing serum malondialdehyde in fish fed HSD, suggesting improvements in immunity and antioxidant capacity. Furthermore, PPS inclusion mitigated damage to intestinal villi induced by HSD. Interestingly, 2.5% PPS increased the abundance of Bacteroidetes and Tenericutes while reducing the abundance of Proteobacteria and Spirochetes, indicating the reshaping of gut microbiota. In summary, dietary PPS alleviated the negative effects of HSD on growth performance, lipid metabolism, immunity, antioxidant capacity, and intestinal morphology and altered microbial composition in rabbitfish. This highlighted the beneficial effects of dietary PPS in fish and suggested it could contribute to the new strategies for treating metabolic syndrome and health impacts in aquatic animals.
C1 [Li, Ruixin; Li, Wenkai; Xie, Jiaying; Liu, Zhixiao; Xiao, Yi; Tocher, Douglas R.; Chen, Cuiying; Lin, Fan; Liu, Xiaojuan; Wang, Shuqi] Shantou Univ, Guangdong Prov Key Labs Marine Biotechnol & Marine, Shantou 515063, Peoples R China.
   [Xie, Dizhi] South China Agr Univ, Sch Marine Sci, Guangzhou 510642, Peoples R China.
   [Hong, Yucong] Guangdong Yuequn Marine Biotechnol Co Ltd, Enterprise Key Lab Micro Feed Aquat Seedlings Guan, Jieyang 515500, Peoples R China.
C3 Shantou University; South China Agricultural University
RP Wang, SQ (corresponding author), Shantou Univ, Guangdong Prov Key Labs Marine Biotechnol & Marine, Shantou 515063, Peoples R China.
EM rxli@stu.edu.cn; 19wkli@stu.edu.cn; 21jyxie1@stu.edu.cn;
   19zxliu@alumni.stu.edu.cn; 21yxiao1@stu.edu.cn; d.r.tocher@stir.ac.uk;
   cychen@stu.edu.cn; linfan@stu.edu.cn; liuxiaojuan@stu.edu.cn;
   xiedizhi@scau.edu.cn; 13822047799@139.com; sqw@stu.edu.cn
RI Li, Wenkai/JNS-2170-2023; Lin, Fan/JZT-1441-2024; chen,
   cuiying/C-9375-2012; Xie, Jiaying/LCP-5061-2024; liu,
   zhixiao/F-8809-2015; Wang, Shuqi/HJA-2592-2022; Tocher,
   Douglas/C-5652-2011
OI Li, Ruixin/0000-0001-7718-1370
FU National Natural Science Foundation of China [32373146]; Guangdong
   Provincial Key RD Program [2021B0202050001]; Innovation and Strong
   School Projects in Guangdong Province [2020ZDZXlO14]; Special Fund for
   Science and Technology of Guangdong Province [210726116902191];
   Guangdong Agriculture Research System [2023KJ150]; General Program of
   the Natural Science Foundation of Guangdong Province [2024A1515012777];
   Scientific Research Start-up Project of Shantou University [NTF23031]
FX This research was fi nancially supported by the National Nat- ural
   Science Foundation of China (32373146), the Guangdong Provincial Key R&D
   Program (2021B0202050001), the Innovation and Strong School Projects in
   Guangdong Province (2020ZDZXlO14), the Special Fund for Science and
   Technology of Guangdong Province (210726116902191), the Guangdong
   Agriculture Research System (2023KJ150), the General Program of the
   Natural Science Foundation of <EM><STRONG> </STRONG></EM>Guangdong
   Province (2024A1515012777), and the Scientific Research Start-up Project
   of Shantou University (NTF23031).
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NR 55
TC 1
Z9 1
U1 12
U2 21
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1353-5773
EI 1365-2095
J9 AQUACULT NUTR
JI Aquac. Nutr.
PD OCT 23
PY 2024
VL 2024
AR 7022813
DI 10.1155/2024/7022813
PG 13
WC Fisheries
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Fisheries
GA K9O1B
UT WOS:001347108400002
OA gold
DA 2025-06-11
ER

PT J
AU Barisik, V
   Korkmaz, HA
   Çekdemir, YE
   Torlak, D
   Aktug, H
   Yavasoglu, A
   Erbas, O
AF Barisik, V.
   Korkmaz, H. A.
   Cekdemir, Y. E.
   Torlak, D.
   Aktug, H.
   Yavasoglu, A.
   Erbas, O.
TI THE THERAPEUTIC EFFECT OF ALLOPURINOL IN FATTY LIVER DISEASE IN RATS
SO ACTA ENDOCRINOLOGICA-BUCHAREST
LA English
DT Article
DE Allopurinol; hyperuricemia; non-alcoholic fatty liver disease
ID SERUM URIC-ACID; NF-KAPPA-B; OXIDATIVE STRESS; INSULIN-RESISTANCE;
   METABOLIC SYNDROME; FRUCTOSE CONSUMPTION; OBESE ADOLESCENTS;
   STEATOHEPATITIS; INFLAMMATION; FIBROSIS
AB Background. Hyperuricemia is associated with non-alcoholic fatty liver disease (NAFLD).Aim. We therefore aimed at evaluating the influence of allopurinol on the course of NAFLD in rats.Study Design. We divided 21 mature albino Sprague Dawley rats into three groups: controls (n = 7, normal diet for 12 weeks); NAFLD rat models (by feeding water containing 30% fructose for first 8 weeks) treated with allopurinol subsequently for the next 4 weeks (n = 7); and similar case treated with placebo (saline) subsequently for the next 4 weeks (n = 7).Methods. We compared the histopathological scores, IL-1 and IL-2 immunoexpression levels across the groups. Liver histopathological score was determined by observing the steatosis (the percentage of liver cells containing fat): <25% = 1+, 25% -50% = 2+, 51% -75% = 3+, >75% = 4+; inflammation and necrosis: 1 focus per low-power field = 1+; and 2 or more foci = 2+. The number of liver IL-1 and IL-2 positive cells was measured by systematically scoring at least 100 hepatocyte cells per field in 10 fields of tissue sections by a magnification of 100. Results. Xanthine oxidase (XO) activity and lipid peroxidation was significantly different in the allopurinol group compared to the saline group (XO; 0.098 +/- 0.006 mU/mg vs. 0.162 +/- 0.008 mU/mg, p = 0.01, 0.116 +/- 0.040 nmol malondialdehyde/mg versus 0.246 +/- 0.040 nmol malondialdehyde /mg, p = 0.01). The allopurinol group had lower histopathological scores, IL-1 and IL-2 immunoexpression levels in the liver compared to the saline group (2.13 +/- 0.35 against 5.45 +/- 0.24, p = 0.003, IL-1; 5.76 +/- 0.43 against 12.85 +/- 3.26, p = 0.023, IL-2; 8.55 +/- 1.14 against 56.23 +/- 7.12, p = 0.002).Conclusions. Allopurinol has a therapeutic role against the progression of NAFLD of the rats.
C1 [Barisik, V.] Metropol Med Ctr, Dept Internal Med, Izmir, Turkiye.
   [Korkmaz, H. A.] Dr Behcet Uz Childrens Hosp, Div Pediat Endocrinol, Izmir, Turkiye.
   [Cekdemir, Y. E.] Dokuz Eylul Univ, Dept Radiol, Izmir, Turkiye.
   [Torlak, D.] Acibadem Univ, Dept Pathol, Istanbul, Turkiye.
   [Aktug, H.; Yavasoglu, A.] Ege Univ, Dept Histol & Embryol, Izmir, Turkiye.
   [Erbas, O.] Ege Univ, Dept Physiol, Izmir, Turkiye.
   [Korkmaz, H. A.] Dr Behcet Uz Childrens Hosp, Div Pediat Endocrinol, 1374 St 11 Alsancak Izmir, TR-35210 Izmir, Turkiye.
C3 Izmir Dr Behcet Uz Children's Disease & Surgery Training & Research
   Hospital; Dokuz Eylul University; Acibadem University; Ege University;
   Ege University; Izmir Dr Behcet Uz Children's Disease & Surgery Training
   & Research Hospital
RP Korkmaz, HA (corresponding author), Dr Behcet Uz Childrens Hosp, Div Pediat Endocrinol, 1374 St 11 Alsancak Izmir, TR-35210 Izmir, Turkiye.
EM hanilkorkmaz@gmail.com
RI Artuvan Korkmaz, Hazal/AAQ-4359-2021; Yavasoglu, Altug/LPQ-1313-2024;
   ERBAS, OYTUN/ABA-7380-2021
OI Erbas, Oytun/0000-0001-5427-8428
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NR 52
TC 1
Z9 1
U1 0
U2 31
PU EDITURA ACAD ROMANE
PI BUCURESTI
PA CALEA 13 SEPTEMBRIE NR 13, SECTOR 5, BUCURESTI 050711, ROMANIA
SN 1841-0987
EI 1843-066X
J9 ACTA ENDOCRINOL-BUCH
JI Acta Endocrinol.
PD APR-JUN
PY 2023
VL 19
IS 2
BP 155
EP 162
DI 10.4183/aeb.2023.155
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA EF5W3
UT WOS:001137531100019
PM 37908883
OA Green Published
DA 2025-06-11
ER

PT J
AU Berdina, O
   Madaeva, I
   Bolshakova, S
   Sholokhov, L
   Rychkova, L
AF Berdina, Olga
   Madaeva, Irina
   Bolshakova, Svetlana
   Sholokhov, Leonid
   Rychkova, Liubov
TI Circadian Rhythm of Salivary Cortisol in Obese Adolescents With and
   Without Apnea: A Pilot Study
SO FRONTIERS IN PEDIATRICS
LA English
DT Article
DE salivary cortisol; circadian rhythm; obstructive sleep apnea; obesity;
   adolescents
ID OBSTRUCTIVE SLEEP-APNEA; PITUITARY-ADRENAL AXIS; METABOLIC SYNDROME;
   SERUM CORTISOL; BLOOD-PRESSURE; HAIR CORTISOL; MEN; CHILDREN;
   OVERWEIGHT; ASSOCIATION
AB Background and ObjectiveObstructive sleep apnea (OSA) and obesity are associated with stress system activation involving the hypothalamic-pituitary-adrenal (HPA) axis in adults, but these effects in childhood and adolescence remain unclear. We examined diurnal salivary cortisol as a measurement of the HPA axis function in obese adolescents with and without OSA and the relationships between cortisol levels, body weight, and parameters of polysomnography (PSG). MethodsAfter PSG, saliva samples were collected from obese participants (with and without OSA) and lean participants four times over a 24-h period, namely, at 7:00 h (m-sCort), 13:00 h (a-sCort), 19:00 h (e-sCort), and 23:00 h (n-sCort). An enzyme-linked immunosorbent assay (ELISA) was used to measure salivary cortisol levels. The mean values of cortisol levels and fixed-time point diurnal cortisol slope (DCS) were calculated and compared among the three study groups. Correlations between parameters were analyzed using Spearman's correlation coefficients. ResultsObese OSA participants had significantly higher e-sCort and n-sCort levels than both obese non-OSA participants and lean controls. However, m-sCort and a-sCort in these patients had a pronounced upward trend. M-sCort was significantly correlated with both the lowest oxygen saturation (SpO(2)) and time with SpO(2) <90%. Moreover, in the obese OSA group, DCS was significantly flatter than in the other two groups. The a-sCort in obese non-OSA participants was significantly higher than that in the lean control group and, surprisingly, was positively correlated with the apnea/hypopnea index. Additionally, m-sCort was related to body weight. ConclusionThis study provided further evidence for alterations in diurnal cortisol production in obese adolescents, which may indicate a chronically stressed HPA axis. However, there were significant differences in salivary cortisol parameters between participants with and without OSA. Furthermore, patients with OSA had more associations between time-point cortisol levels and OSA-related indices. Nonetheless, this research is a pilot study, and further investigations are necessary.
C1 [Berdina, Olga; Madaeva, Irina; Bolshakova, Svetlana] Sci Ctr Family Hlth & Human Reprod Problems, Dept Personalized & Prevent Med, Lab Somnol & Neurophysiol, Irkutsk, Russia.
   [Sholokhov, Leonid] Sci Ctr Family Hlth & Human Reprod Problems, Dept Reprod Hlth Care, Lab Physiol & Pathol Endocrine Syst, Irkutsk, Russia.
   [Rychkova, Liubov] Sci Ctr Family Hlth & Human Reprod Problems, Irkutsk, Russia.
C3 Irkutsk Science Centre of the Russian Academy of Sciences; Scientific
   Centre for Family Health & Human Reproduction Problems; Irkutsk Science
   Centre of the Russian Academy of Sciences; Scientific Centre for Family
   Health & Human Reproduction Problems; Irkutsk Science Centre of the
   Russian Academy of Sciences; Scientific Centre for Family Health & Human
   Reproduction Problems
RP Berdina, O (corresponding author), Sci Ctr Family Hlth & Human Reprod Problems, Dept Personalized & Prevent Med, Lab Somnol & Neurophysiol, Irkutsk, Russia.
EM goodnight_84@mail.ru
RI Madaeva, Irina/O-6301-2015
OI Madaeva, Irina/0000-0003-3423-7260
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NR 48
TC 4
Z9 5
U1 0
U2 6
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-2360
J9 FRONT PEDIATR
JI Front. Pediatr.
PD APR 26
PY 2022
VL 10
AR 795635
DI 10.3389/fped.2022.795635
PG 9
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Pediatrics
GA 1F3XY
UT WOS:000795105000001
PM 35558378
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Al-Zalabani, AH
   Wesselius, A
   Yu, EYW
   van den Brandt, P
   Grant, EJ
   White, E
   Skeie, G
   Liedberg, F
   Weiderpass, E
   Zeegers, MP
AF Al-Zalabani, Abdulmohsen H.
   Wesselius, Anke
   Yu, Evan Yi-Wen
   van den Brandt, Piet
   Grant, Eric J.
   White, Emily
   Skeie, Guri
   Liedberg, Fredrik
   Weiderpass, Elisabete
   Zeegers, Maurice P.
TI Tea consumption and risk of bladder cancer in the Bladder Cancer
   Epidemiology and Nutritional Determinants (BLEND) Study: Pooled analysis
   of 12 international cohort studies
SO CLINICAL NUTRITION
LA English
DT Article
DE Urinary bladder cancer; Tea; Smoking; Dose-response analysis; Cohort
   studies; Epidemiology
ID GREEN TEA; OXIDATIVE STRESS; FLUID INTAKE; BLACK TEA; DESIGN;
   CARCINOGENESIS; CAFFEINE; SMOKERS; COFFEE; INHIBITION
AB Background & aims: Tea has been shown to be associated with reduced risk of several diseases including cardiovascular diseases, stroke, metabolic syndrome, and obesity. However, the results on the relation-ship between tea consumption and bladder cancer are conflicting. This research aimed to assess the association between tea consumption and risk of bladder cancer using a pooled analysis of prospective cohort data. Methods: Individual data from 532,949 participants in 12 cohort studies, were pooled for analyses. Cox regression models stratified by study centre was used to estimate hazard ratios (HR) and corresponding 95% CIs. Fractional polynomial regression models were used to examine the dose-response relationship. Results: A higher level of tea consumption was associated with lower risk of bladder cancer incidence (compared with no tea consumption: HR = 0.87, 95% C.I. = 0.77-0.98 for low consumption; HR = 0.86, 95% C.I. = 0.77-0.96 for moderate consumption; HR = 0.84, 95% C.I. = 0.75-0.95 for high consumption). When stratified by sex and smoking status, this reduced risk was statistically significant among men and current and former smokers. In addition, dose-response analyses showed a lower bladder cancer risk with increment of 100 ml of tea consumption per day (HR-increment = 0.97; 95% CI = 0.96-0.98). A similar inverse association was found among males, current and former smokers while never smokers and females showed non-significant results, suggesting potential sex-dependent effect. Conclusions: Higher consumption of tea is associated with reduced risk of bladder cancer with potential interaction with sex and smoking status. Further studies are needed to clarify the mechanisms for a protective effect of tea (e.g. inhibition of the survival and proliferation of cancer cells and antiinflammatory mechanisms) and its interaction with smoking and sex. (c) 2022 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
C1 [Al-Zalabani, Abdulmohsen H.] Taibah Univ, Coll Med, Dept Family & Community Med, Madinah 41541, Saudi Arabia.
   [Wesselius, Anke; Zeegers, Maurice P.] Maastricht Univ, Sch Nutr & Translat Res Metab, Dept Epidemiol, Univ Singel 40,Room C5-570, NL-6229 ER Maastricht, Netherlands.
   [Yu, Evan Yi-Wen] Southeast Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Key Lab Environm Med & Engn,Minist Educ, Nanjing, Peoples R China.
   [Yu, Evan Yi-Wen] Maastricht Univ, Sch Nutr & Translat Res Metab, CAPHRI Care & Publ Hlth Res Inst, Dept Epidemiol, Maastricht, Netherlands.
   [van den Brandt, Piet] Maastricht Univ Med Ctr, Sch Oncol & Dev Biol, Dept Epidemiol, Maastricht, Netherlands.
   [van den Brandt, Piet] Maastricht Univ Med Ctr, Sch Publ Hlth, Dept Epidemiol, Maastricht, Netherlands.
   [van den Brandt, Piet] Maastricht Univ Med Ctr, Sch Primary Care, Dept Epidemiol, Maastricht, Netherlands.
   [Grant, Eric J.] Radiat Effects Res Fdn, Dept Epidemiol, Hiroshima, Japan.
   [White, Emily] Fred Hutchinson Canc Res Ctr, 1124 Columbia St, Seattle, WA 98104 USA.
   [Skeie, Guri] UiT Arctic Univ Norway, Dept Community Med, Tromso, Norway.
   [Liedberg, Fredrik] Lund Univ, Inst Translat Med, Malmo, Sweden.
   [Weiderpass, Elisabete] World Hlth Org, Int Agcy Res Canc, Lyon, France.
   [Zeegers, Maurice P.] Maastricht Univ, CAPHRI Sch Publ Hlth & Primary Care, Maastricht, Netherlands.
C3 Taibah University; Maastricht University; Ministry of Education - China;
   Southeast University - China; Maastricht University; Maastricht
   University; Maastricht University Medical Centre (MUMC); Maastricht
   University; Maastricht University Medical Centre (MUMC); Maastricht
   University; Maastricht University Medical Centre (MUMC); Radiation
   Effects Research Foundation - Japan; Fred Hutchinson Cancer Center; UiT
   The Arctic University of Tromso; Lund University; World Health
   Organization; International Agency for Research on Cancer (IARC);
   Maastricht University
RP Wesselius, A (corresponding author), Maastricht Univ, Sch Nutr & Translat Res Metab, Dept Epidemiol, Univ Singel 40,Room C5-570, NL-6229 ER Maastricht, Netherlands.
EM anke.wesselius@maastrichtuniversity.nl
RI Al-Zalabani, Abdulmohsen/E-9869-2013; Weiderpass, Elisabete/M-4029-2016
OI Weiderpass, Elisabete/0000-0003-2237-0128; Wesselius,
   Anke/0000-0003-4474-9665; Liedberg, Fredrik/0000-0001-8193-0370; van den
   Brandt, Piet/0000-0001-8781-8099; Skeie, Guri/0000-0003-2476-4251
FU World Cancer Research Fund International [WCRF 2012/590]; European
   Commission [FP7-PEOPLE-618308]; Dutch Cancer Society; US Department of
   Energy (DOE); DOE [DEHS0000031]; RERF [RP-A5-12]; National Cancer
   Institute [R01CA74846]; Radiation Effects Research Foundation (RERF),
   Hiroshima and Nagasaki, Japan, a public interest foundation - Japanese
   Ministry of Health, Labour and Welfare (MHLW); "Europe Against Cancer"
   Programme of the European Commission (SANCO); Ligue contre le Cancer
   (France); Societe 3 M (France); Mutuelle Generale de l'Education
   Nationale; Institut National de la Sante et de la Recherche Medicale
   (INSERM); Institute Gustave Roussy; German Cancer Aid; German Cancer
   Research Centre; German Federal Ministry of Education and Research;
   Danish Cancer Society; Health Research Fund (FIS) of the Spanish
   Ministry of Health; Spanish Regional Government of Andalucia; Spanish
   Regional Government of Asturias; Spanish Regional Government of Basque
   Country; Spanish Regional Government of Murcia; Spanish Regional
   Government of Navarra; Cancer Research UK; Medical Research Council, UK;
   Stroke Association, UK; British Heart Foundation; Department of Health,
   UK; Food Standards Agency, UK; Wellcome Trust, UK; Italian Association
   for Research on Cancer; Italian National Research Council; Dutch
   Ministry of Public Health, Welfare and Sports; Dutch Prevention Funds;
   LK Research Funds; Dutch ZON (Zorg Onderzoek Nederland); World Cancer
   Research Fund; Swedish Cancer Society; Swedish Scientific Council;
   Regional Government of Skane, Sweden; Norwegian Cancer Society;
   Norwegian Research Council; Centre de Recherche etd'In-formation
   Nutritionnelles (CERIN)
FX This work was partly funded by the World Cancer Research Fund
   International (WCRF 2012/590) and European Commission
   (FP7-PEOPLE-618308) . The Netherlands Cohort Study on diet and can-cer
   was supported by the Dutch Cancer Society. The RERF atomic bomb
   survivors Study was supported by The Radiation Effects Research
   Foundation (RERF) , Hiroshima and Nagasaki, Japan, a public interest
   foundation funded by the Japanese Ministry of Health, Labour and Welfare
   (MHLW) and the US Department of Energy (DOE) . The research was also
   funded in part through DOE award DEHS0000031 to the National Academy of
   Sciences. This publication was supported by RERF Research Protocol
   RP-A5-12. The VITamins and Lifestyle Study (VITAL) was supported by a
   grant (R01CA74846) from the National Cancer Institute. The Euro-pean
   Prospective Investigation into Cancer and Nutrition (EPIC) was carried
   out with financial support of the "Europe Against Cancer" Programme of
   the European Commission (SANCO) ; Ligue contre le Cancer (France) ;
   Societe 3 M (France) ; Mutuelle Generale de l'Education Nationale;
   Institut National de la Sante et de la Recherche M?edicale (INSERM) ;
   Institute Gustave Roussy; German Cancer Aid; German Cancer Research
   Centre; German Federal Ministry of Education and Research; Danish Cancer
   Society; Health Research Fund (FIS) of the Spanish Ministry of Health;
   the Spanish Regional Governments of Andalucia, Asturias, Basque Country,
   Murcia and Navarra; Cancer Research UK; Medical Research Council, UK;
   Stroke Association, UK; British Heart Foundation; Department of Health,
   UK; Food Standards Agency, UK; Wellcome Trust, UK; Italian Association
   for Research on Cancer; Italian National Research Council; Dutch
   Ministry of Public Health, Welfare and Sports; Dutch Prevention Funds;
   LK Research Funds; Dutch ZON (Zorg Onderzoek Nederland) ; World Cancer
   Research Fund; Swedish Cancer Society; Swedish Scientific Council;
   Regional Government of Skane, Sweden; Norwegian Cancer Society;Norwegian
   Research Council. Partial support for the publication this supplement
   was provided by the Centre de Recherche etd'In-formation Nutritionnelles
   (CERIN) .
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NR 60
TC 17
Z9 17
U1 3
U2 13
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0261-5614
EI 1532-1983
J9 CLIN NUTR
JI Clin. Nutr.
PD MAY
PY 2022
VL 41
IS 5
BP 1122
EP 1130
DI 10.1016/j.clnu.2022.03.020
EA APR 2022
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 0V1DR
UT WOS:000788086300013
PM 35413574
OA Green Published, Green Submitted, hybrid
DA 2025-06-11
ER

PT J
AU Okamura, T
   Hashimoto, Y
   Hamaguchi, M
   Obora, A
   Kojima, T
   Fukui, M
AF Okamura, Takuro
   Hashimoto, Yoshitaka
   Hamaguchi, Masahide
   Obora, Akihiro
   Kojima, Takao
   Fukui, Michiaki
TI The visceral adiposity index is a predictor of incident nonalcoholic
   fatty liver disease: A population-based longitudinal study
SO CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY
LA English
DT Article
DE Cohort study; Epidemiology; Non-alcoholic fatty liver disease; Visceral
   adiposity index
ID INDUCED INSULIN-RESISTANCE; NECROSIS-FACTOR-ALPHA; METABOLIC SYNDROME;
   OXIDATIVE STRESS; ACCUMULATION; OBESITY; INFLAMMATION; ACCURACY;
   HEALTHY; IMPACT
AB Background and aims: : Visceral adiposity index (VAI), calculated with body mass index, high density lipoprotein cholesterol, triglyceride and waist circumference, has been proposed as a marker of visceral fat accumulation and dysfunction. Methods: The impact of VAI on incident nonalcoholic fatty liver disease (NAFLD) in a historical cohort study of 8399 (3773 men and 4626 women) participants. NAFLD was defined as having fatty liver diagnosed by abdominal ultrasonography. We divided the participants into two groups according to sex and into quartiles according to VAI (Q1-4). We calculated VAI using the formulas. Men: VAI = [waist circumference (WC)/39.68 + (1.88 x body mass index [BMI])] x [triglycerides (TG)/1.03] x [1.31/high-density lipoprotein cholesterol (HDL)]; women: VAI = [WC/36.58+ (1.89 x BMI)] x (TG/0.81) x (1.52/HDL). We performed Cox proportional hazard models, adjusting for age, alanine aminotransferase, fasting plasma glucose, systolic blood pressure, alcohol consumption, smoking status and exercise. Results: During the median 4.5-year follow-up for men and 4.9-year follow-up for women, 1078 participants (737 men and 341 women) developed NAFLD. The 4000 days cumulative incidence rate of NAFLD for men and women were 7.5% and 2.2% in Q1, 14.5% and 4.0% in Q2, 22.3% and 6.7% in Q3 and 33.8% and 16.7% in Q4. The hazard ratios of incident NAFLD in Q4 (VAI: men, >1.13; women, > 0.83) were 3.69 (95% confidence interval 2.84-4.86, P<0.001) in men and 4.93 (3.28-7.73, P<0.001) in women, compared to Q1 (VAI: men, < 0.44; women, < 0.36). Conclusions: The visceral adiposity index can be a predictor of incident NAFLD. (C) 2019 Elsevier Masson SAS. All rights reserved.
C1 [Okamura, Takuro; Hashimoto, Yoshitaka; Hamaguchi, Masahide; Fukui, Michiaki] Kyoto Prefectural Univ Med, Grad Sch Med Sci, Dept Endocrinol & Metab, Kamigyo Ku, 465 Kajii Cho, Kyoto 6028566, Japan.
   [Obora, Akihiro; Kojima, Takao] Asahi Univ Hosp, Dept Gastroenterol, Gifu, Japan.
C3 Kyoto Prefectural University of Medicine; Asahi University
RP Hamaguchi, M (corresponding author), Kyoto Prefectural Univ Med, Grad Sch Med Sci, Dept Endocrinol & Metab, Kamigyo Ku, 465 Kajii Cho, Kyoto 6028566, Japan.
EM mhama@koto.kpu-m.ac.jp
RI Hashimoto, Yoshitaka/AAH-8503-2020; Okamura, Takuro/AAP-3050-2020
OI Okamura, Takuro/0000-0001-7269-1697; Hashimoto,
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NR 42
TC 17
Z9 20
U1 0
U2 4
PU ELSEVIER MASSON, CORP OFF
PI PARIS
PA 65 CAMILLE DESMOULINS CS50083 ISSY-LES-MOULINEAUX, 92442 PARIS, FRANCE
SN 2210-7401
EI 2210-741X
J9 CLIN RES HEPATOL GAS
JI Clin. Res. Hepatol. Gastroenterol.
PD JUN
PY 2020
VL 44
IS 3
BP 375
EP 383
DI 10.1016/j.clinre.2019.04.002
PG 9
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA MD1YF
UT WOS:000543769900026
PM 32434704
OA hybrid
DA 2025-06-11
ER

PT J
AU Mopuri, R
   Ganjayi, M
   Meriga, B
   Koorbanally, NA
   Islam, MS
AF Mopuri, Ramgopal
   Ganjayi, Muniswamy
   Meriga, Balaji
   Koorbanally, Neil Anthony
   Islam, Md. Shahidul
TI The effects of Ficus carica on the activity of enzymes related to
   metabolic syndrome
SO JOURNAL OF FOOD AND DRUG ANALYSIS
LA English
DT Article
DE alpha-amylase; alpha-glucosidase; antioxidants; Ficus carica; pancreatic
   lipase
ID ANTIOXIDANT ACTIVITIES; ALPHA-GLUCOSIDASE; OXIDATIVE STRESS;
   SOUTH-AFRICA; FIG; EXTRACT; PREVENTION; LIPASE; OBESITY; FRUITS
AB The present study aimed to investigate the effects of the various parts of Ficus carica L. (figs) on antioxidant, antidiabetic, and antiobesogenic effects in vitro. Fruit, leaves, and stembark of the F. carica plant were sequentially extracted using organic and inorganic solvents and their total polyphenol and flavonoid contents were estimated. The effects of the extracts on antioxidative, antidiabetic (inhibition of alpha-amylase and alpha-glucosidase enzymes), and antiobesogenic (antilipase) activities were measured using several experimental models. The fruit ethanolic extract contained a high quantity of polyphenols and flavonoids (104.67 +/- 5.51 mu g/mL and 81.67 +/- 4.00 mu g/mL) compared with all other extracts. The activity of the ethanolic extract of F. carica fruit was significantly (p < 0.05) higher than all other extracts and parts of the plant in terms of antioxidative, antidiabetic, and antiobesogenic effects. The IC50 values of the fruit ethanolic extract in terms of antioxidative (134.44 +/- 18.43 mu g/mL), and inhibition of alpha-glucosidase (255.57 +/- 36.46 mu g/mL), alpha-amylase (315.8(+/- 3.83 mu g/mL), and pancreatic lipase (230.475 +/- 9.65 mu g/mL) activity indicate that the activity of fruit ethanolic extract is better than all other extracts of the plant. The gas chromatography-mass spectroscopy analysis of the fruit ethanolic extract showed the presence of a number of bioactive compounds such as butyl butyrate, 5-hydroxymethyl furfural, 1-butoxy-1-isobutoxy butane, malic acid, tetradecanoic acid, phytol acetate, trans phytol, n-hexadecanoic acid, 9Z, 12Z-octadecadienoic acid, stearic acid, sitosterol, 3,5-dihydroxy-6-methyl-2,3-dihydro-4H-pyran-4-one, and 2,4,5-trimethyl-2,4-dihydro-3H-pyrazol-3-one. The results of this study suggest that the ethanolic extract of the fruit of F. carica may have potential antidiabetic and antiobesogenic agents. Copyright (C) 2017, Food and Drug Administration, Taiwan. Published by Elsevier Taiwan LLC.
C1 [Mopuri, Ramgopal; Islam, Md. Shahidul] Univ KwaZulu Natal, Sch Life Sci, Dept Biochem, Westville Campus,Private Bag X54001, ZA-4000 Durban, South Africa.
   [Ganjayi, Muniswamy; Meriga, Balaji] Sri Venkateswara Univ, Dept Biochem, Anim Physiol & Biochem Lab, Tirupati, Andhra Pradesh, India.
   [Koorbanally, Neil Anthony] Univ KwaZulu Natal, Sch Chem & Phys, Westville Campus, Durban, South Africa.
C3 University of Kwazulu Natal; Sri Venkateswara University; University of
   Kwazulu Natal
RP Islam, MS (corresponding author), Univ KwaZulu Natal, Sch Life Sci, Dept Biochem, Westville Campus,Private Bag X54001, ZA-4000 Durban, South Africa.
EM islamd@ukzn.ac.za
RI Islam, Shahidul/N-5897-2013; Meriga, Balaji/ACP-0407-2022; Muni Swamy,
   Ganjayi/GYD-5307-2022; Koorbanally, Neil/N-6000-2013
OI Ganjayi, Muni Swamy/0000-0002-0007-5630
FU University of KwaZulu-Natal, Durban; National Research Foundation,
   Pretoria, South Africa [74297:2010]; College of Agriculture,
   Engineering, and Science of the University of KwaZulu-Natal, Durban,
   South Africa
FX The study was supported by a competitive research grant from the
   University of KwaZulu-Natal, Durban; grant support for Young and Women
   researchers (Grant no. 74297:2010) from the National Research
   Foundation, Pretoria, South Africa. First author received a Postdoctoral
   Fellowship from the College of Agriculture, Engineering, and Science of
   the University of KwaZulu-Natal, Durban, South Africa.
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NR 44
TC 54
Z9 56
U1 1
U2 19
PU FOOD & DRUG ADMINSTRATION
PI TAIPEI
PA 161-2 KUNYANG STREET, NANGANG, TAIPEI, 00000, TAIWAN
SN 1021-9498
J9 J FOOD DRUG ANAL
JI J. Food Drug Anal.
PD JAN
PY 2018
VL 26
IS 1
BP 201
EP 210
DI 10.1016/j.jfda.2017.03.001
PG 10
WC Food Science & Technology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Pharmacology & Pharmacy
GA GD1FN
UT WOS:000430245600023
PM 29389556
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Sobers-Grannum, N
   Murphy, MM
   Nielsen, A
   Guell, C
   Samuels, TA
   Bishop, L
   Unwin, N
AF Sobers-Grannum, Natasha
   Murphy, Madhuvanti M.
   Nielsen, Anders
   Guell, Cornelia
   Samuels, T. Alafia
   Bishop, Lisa
   Unwin, Nigel
TI Female Gender Is a Social Determinant of Diabetes in the Caribbean: A
   Systematic Review and Meta-Analysis
SO PLOS ONE
LA English
DT Article
ID PERCEIVED ACADEMIC STRESS; BODY-MASS INDEX; LATIN-AMERICA;
   SOCIODEMOGRAPHIC CHARACTERISTICS; PHYSICAL-ACTIVITY; DIETARY PATTERNS;
   BLOOD-PRESSURE; OLDER-ADULTS; WAIST CIRCUMFERENCE; METABOLIC SYNDROME
AB Background
   Diabetes (DM) is estimated to affect 10-15% of the adult population in the Caribbean. Preventive efforts require population wide measures to address its social determinants. We undertook a systematic review to determine current knowledge about the social distribution of diabetes, its risk factors and major complications in the Caribbean. This paper describes our findings on the distribution by gender.
   Methods
   We searched Medline, Embase and five databases through the Virtual Health Library, for Caribbean studies published between 2007 and 2013 that described the distribution by gender for: known risk factors for Type 2 DM, prevalence of DM, and DM control or complications. PRISMA guidance on reporting systematic reviews on health equity was followed. Only quantitative studies (n>50) were included; each was assessed for risk of bias. Meta-analyses were performed, where appropriate, on studies with a low or medium risk of bias, using random effects models.
   Results
   We found 50 articles from 27 studies, yielding 118 relationships between gender and the outcomes. Women were more likely to have DM, obesity, be less physically active but less likely to smoke. In meta-analyses of good quality population-based studies odds ratios for women vs. men for DM, obesity and smoking were: 1.65 (95% CI 1.43, 1.91), 3.10 (2.43, 3.94), and 0.24 (0.17, 0.34). Three studies found men more likely to have better glycaemic control but only one achieved statistical significance.
   Conclusion and Implications
   Female gender is a determinant of DM prevalence in the Caribbean. In the vast majority of world regions women are at a similar or lower risk of type 2 diabetes than men, even when obesity is higher in women. Caribbean female excess of diabetes may be due to a much greater excess of risk factors in women, especially obesity. These findings have major implications for preventive policies and research.
C1 [Sobers-Grannum, Natasha; Murphy, Madhuvanti M.; Nielsen, Anders; Guell, Cornelia; Samuels, T. Alafia; Bishop, Lisa; Unwin, Nigel] Univ W Indies, Fac Med Sci, Bridgetown, Barbados.
   [Guell, Cornelia; Unwin, Nigel] Univ Cambridge, MRC Epidemiol Unit, Cambridge, England.
   [Guell, Cornelia; Unwin, Nigel] Univ Cambridge, UKCRC Ctr Diet & Activ Res CEDAR, Cambridge, England.
   [Unwin, Nigel] Univ W Indies, Chron Dis Res Ctr, Res Inst Trop Med, Bridgetown, Barbados.
C3 University West Indies Mona Jamaica; University of the West Indies Open
   Campus; University of Cambridge; University of Cambridge; University
   West Indies Mona Jamaica; University of the West Indies Open Campus
RP Sobers-Grannum, N (corresponding author), Univ W Indies, Fac Med Sci, Bridgetown, Barbados.
EM Natasha.sobers@cavehill.uwi.edu
RI Nielsen, Anders/I-2536-2016; Murphy, Madhuvanti/MIP-7155-2025; Guell,
   Cornelia/GYU-2765-2022
OI Guell, Cornelia/0000-0003-0105-410X; Sobers,
   Natasha/0000-0002-9444-0706; Murphy, Madhuvanti/0000-0002-9346-5450;
   Unwin, Nigel/0000-0002-1368-1648
FU National Institute on Minority Health and Health Disparities
   [U24MD006959]; ESRC [ES/G007462/1] Funding Source: UKRI; MRC
   [MR/K023187/1, MC_UU_12015/6] Funding Source: UKRI
FX This study was funded in part by grant number U24MD006959 from the
   National Institute on Minority Health and Health Disparities. The
   funders had no role in the study design, data collection, analysis,
   decision to publish or preparation of the manuscript. There were no
   other funders associated with this work.
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NR 76
TC 41
Z9 50
U1 0
U2 3
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAY 21
PY 2015
VL 10
IS 5
AR e0126799
DI 10.1371/journal.pone.0126799
PG 22
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Science & Technology - Other Topics
GA CK7VW
UT WOS:000356444000032
PM 25996933
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Modesti, PA
   Bianchi, S
   Borghi, C
   Cameli, M
   Capasso, G
   Ceriello, A
   Ciccone, MM
   Germanò, G
   Maiello, M
   Muiesan, ML
   Novo, S
   Padeletti, L
   Palmiero, P
   Pillon, S
   Rotella, CM
   Saba, PS
   Scicchitano, P
   Trimarco, B
   Volpe, M
   Pedrinelli, R
   Di Biase, M
AF Modesti, Pietro A.
   Bianchi, Stefano
   Borghi, Claudio
   Cameli, Matteo
   Capasso, Giovambattista
   Ceriello, Antonio
   Ciccone, Marco Matteo
   Germano, Giuseppe
   Maiello, Maria
   Muiesan, Maria Lorenza
   Novo, Salvatore
   Padeletti, Luigi
   Palmiero, Pasquale
   Pillon, Sergio
   Rotella, Carlo Maria
   Saba, Pier Sergio
   Scicchitano, Pietro
   Trimarco, Bruno
   Volpe, Massimo
   Pedrinelli, Roberto
   Di Biase, Matteo
CA SIC
   SIIA
   SIMI
   SIN
   AMD
   AIAC
   SIO
   Soc Italiana
   ONSET
TI Cardiovascular health in migrants: current status and issues for
   prevention. A collaborative multidisciplinary task force report
SO JOURNAL OF CARDIOVASCULAR MEDICINE
LA English
DT Article
DE cardiovascular risk; ethnic; ethnicity; global health; immigration;
   migrant; minorities
ID CORONARY-HEART-DISEASE; RENAL REPLACEMENT THERAPY; AFRICAN-ORIGIN
   POPULATIONS; RISK-FACTORS; BLOOD-PRESSURE; ETHNIC-GROUPS; FOLLOW-UP;
   GLOBAL BURDEN; SOUTH ASIANS; DIABETES-MELLITUS
AB Objectives To review information on cardiovascular health and migration, to stress the attention of researchers that much needs to be done in the collection of sound data in Italy and to allow policy-makers to identify this issue as an important public health concern.
   Background In Italy, the rate of immigrants in the total number of residents increased from 2.5% in 1990 to 7.4% in 2010, and currently exceeds 10% in regions such as Lombardia, Emilia Romagna and Toscana.
   Methods A consensus statement was developed by approaching relevant Italian national scientific societies involved in cardiovascular prevention. Task force members were identified by the president and/or the boards of each relevant scientific society or working group, as appropriate. To obtain a widespread consensus, drafts were merged and distributed to the scientific societies for local evaluation and revision by as many experts as possible. The ensuing final draft was finally approved by scientific societies.
   Results In several western European countries, the prevalence of hypertension, diabetes, chronic kidney disease, obesity and metabolic syndrome was found to be higher among immigrants than in the native population. Although migrants are often initially healthier than non-migrant populations in their host countries, genetic factors, and changing environments with lifestyle changes, social exclusion and insufficient medical control may expose them to health challenges. Cultural reasons may also hamper both the dissemination of prevention strategies and migrant communication with healthcare providers. However, great diversity exists across and within different groups of migrants, making generalizations very difficult and many countries do not collect registry or survey data for migrant's health.
   Conclusions In the present economic context, the European Union is placing great attention to improve data collection for migrant health and to support the implementation of specific prevention policies aimed at limiting the future burden of cardiovascular and renal disease, and the consequent load for health systems. Wider initiatives on the topic are awaited in Italy.
C1 [Modesti, Pietro A.; Padeletti, Luigi] Univ Florence, Dept Med Sperimentale & Clin, I-50134 Florence, Italy.
   [Bianchi, Stefano] Ospedali Riuniti Livorno, Dept Med Interna Nefrol & Dialisi, Livorno, Italy.
   [Borghi, Claudio] S Orsola Malpighi Univ Hosp, Dept Sci Med & Chirurg, Bologna, Italy.
   [Cameli, Matteo] Univ Siena, Dept Malattie Cardiovasc, I-53100 Siena, Italy.
   [Capasso, Giovambattista] Univ Naples 2, Dept Nephrol, Naples, Italy.
   [Ceriello, Antonio] Inst Invest Biomed August Pi & Sunyer, Barcelona, Spain.
   [Ciccone, Marco Matteo; Scicchitano, Pietro] Univ Bari, Sez Malattie Apparato Cardiovasc, DETO, Bari, Italy.
   [Germano, Giuseppe] Univ Roma La Sapienza, Dept Sci Cardiovasc Resp Geriat & Nefrol, Rome, Italy.
   [Maiello, Maria] AS Dept Cardiol, Brindisi Dist, Italy.
   [Muiesan, Maria Lorenza] Univ Brescia, Dept Clin & Expt Sci, Brescia, Italy.
   [Novo, Salvatore] Univ Palermo, Div Cardiol, Dipartimanto Med Interna Malattie Cardiovasc & Ne, Palermo, Italy.
   [Palmiero, Pasquale] ASL BR, Div Cardiol, Brindisi, Italy.
   [Pillon, Sergio] AO San Camillo Forlanini, Dipartimento Cardiovasc, UOD Telemed, Rome, Italy.
   [Rotella, Carlo Maria] Univ Florence, Sez Endocrinol, Dept Fisiopatol Clin, Div Cardiol, Florence, Italy.
   [Saba, Pier Sergio] AOU Sassari, Div Cardiol, Sassari, Italy.
   [Trimarco, Bruno] Univ Naples Federico II, Dept Adv Biomed Sci, Naples, Italy.
   [Volpe, Massimo] Univ Roma La Sapienza, Fac Med & Psicol, Azienda Osped St Andrea, Div Cardiol,Dept Med Clin & Mol, I-00185 Rome, Italy.
   [Volpe, Massimo] IRCCS Neuromed, Rome, Italy.
   [Pedrinelli, Roberto] Univ Pisa, Dept Cardio Torac & Vasc, Pisa, Italy.
   [Di Biase, Matteo] Univ Foggia, Dept Sci Med & Chirurg, Foggia, Italy.
C3 University of Florence; IRCCS Azienda Ospedaliero-Universitaria di
   Bologna; University of Siena; Universita della Campania Vanvitelli;
   University of Barcelona; Hospital Clinic de Barcelona; IDIBAPS;
   Universita degli Studi di Bari Aldo Moro; Sapienza University Rome;
   University of Brescia; University of Palermo; Azienda Ospedaliera San
   Camillo-Forlanini; University of Florence; University of Naples Federico
   II; Sapienza University Rome; Azienda Ospedaliera Sant'Andrea; IRCCS
   Neuromed; University of Pisa; University of Foggia
RP Modesti, PA (corresponding author), Univ Florence, Dept Med Sperimentale & Clin, Largo Brambilla 3, I-50134 Florence, Italy.
EM pamodesti@unifi.it
RI Saba, Pier/AAH-3180-2019; Muiesan, M.L./AAC-2060-2022; Capasso,
   Giovambattista/AEZ-8886-2022; Volpe, Massimo/K-5240-2016; Ceriello,
   Antonio/J-9575-2016; Scicchitano, Pietro/K-8870-2016; Trimarco,
   Bruno/K-7851-2016; Palmiero, Pasquale/F-4200-2016; Cameli,
   Matteo/K-7231-2016; Modesti, Pietro Amedeo/B-2638-2012; Ciccone,
   Marco/C-5271-2013
OI Scicchitano, Pietro/0000-0003-0471-0053; Trimarco,
   Bruno/0000-0002-0701-6449; Saba, Pier Sergio/0000-0001-8196-8491;
   Ceriello, Antonio/0000-0001-8122-3203; Novo,
   Salvatore/0000-0002-7995-184X; Pillon, Sergio/0000-0002-8076-964X;
   Palmiero, Pasquale/0000-0001-8285-1623; Cameli,
   Matteo/0000-0003-3872-8964; Modesti, Pietro Amedeo/0000-0002-9511-2173;
   Volpe, Massimo/0000-0002-9642-8380; Ciccone, Marco/0000-0002-5710-4228;
   Capasso, Giovambattista/0000-0003-3469-8614; Rotella, Carlo
   Maria/0000-0001-9462-2334
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NR 124
TC 30
Z9 31
U1 0
U2 31
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1558-2027
EI 1558-2035
J9 J CARDIOVASC MED
JI J. Cardiovasc. Med.
PD SEP
PY 2014
VL 15
IS 9
BP 683
EP 692
DI 10.2459/JCM.0000000000000069
PG 10
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA AN1VM
UT WOS:000340371900001
PM 25090156
DA 2025-06-11
ER

PT J
AU Sharma, A
   Sarwal, Y
   Devi, NK
   Saraswathy, KN
AF Sharma, Apoorva
   Sarwal, Yamini
   Devi, Naorem Kiranmala
   Saraswathy, Kallur Nava
TI Polycystic Ovary Syndrome prevalence and associated sociodemographic
   risk factors: a study among young adults in Delhi NCR, India
SO REPRODUCTIVE HEALTH
LA English
DT Article
DE Polycystic Ovary Syndrome (PCOS); Prevalence; Sociodemographic Risk
   Factors; Young Adults; Delhi NCR
ID METABOLIC SYNDROME; LIFE-STYLE; WOMEN; OBESITY; OVERWEIGHT; TRANSITION;
   PATTERNS; DISEASE; STRESS; GIRLS
AB IntroductionPolycystic Ovary Syndrome (PCOS) is a prevalent yet under-researched endocrinologic disorder affecting females of reproductive age, characterized by menstrual dysfunction, infertility, hirsutism, acne, and obesity. Despite its global prevalence, with rates varying significantly among Asian communities, there is a notable lack of region-specific epidemiological data, particularly for urban areas in India. The aim of this study is to assess the prevalence of PCOS and associated sociodemographic risk factors among young adult females in Delhi and National Capital Region (NCR), India.MethodsThis study is comprised of two components: a cross-sectional survey and a systematic review. The cross-sectional survey involved 1,164 college-going females aged 18-25 years in Delhi NCR, with data collected through a structured interview schedule assessing sociodemographic variables and PCOS symptoms. PCOS diagnosis was based on the already diagnosed cases and cases diagnosed during the study (Rotterdam criteria, 2003), through symptoms and additional assessment through ultrasonography. The systematic review analysed prevalence studies from 2010 to 2024 across India, focusing on the similar age group.ResultsThe study found a high 17.40% prevalence rate of PCOS among the participants, with 70.30% already diagnosed and 29.70% newly diagnosed during the study. The prevalence is significantly higher compared to the pooled prevalence of 8.41% reported in previous studies across India. Sociodemographic factors such as age (20 years and above), higher education, ancestry (East India and immigrants), and nuclear family structure were associated with increased PCOS risk. Conversely, factors like belonging to the OBC category and lower middle class were linked to reduced risk.DiscussionThe high prevalence of PCOS in Delhi NCR compared to other regions highlights the need for targeted epidemiological research and intervention strategies in urban settings. The association of PCOS with modern lifestyle factors and socioeconomic status underscores the importance of addressing these determinants in managing PCOS effectively. The study contributes valuable insights into the sociodemographic dimensions of PCOS and calls for more comprehensive studies to inform public health strategies.
C1 [Sharma, Apoorva; Devi, Naorem Kiranmala; Saraswathy, Kallur Nava] Univ Delhi, Dept Anthropol, New Delhi, India.
   [Sarwal, Yamini] VMMC & Safdarjung Hosp, New Delhi, India.
C3 University of Delhi; Vardhman Mahavir Medical College & Safdarjung
   Hospital
RP Saraswathy, KN (corresponding author), Univ Delhi, Dept Anthropol, New Delhi, India.
EM knsaraswathy@yahoo.com
RI Sarwal, Yamini/AAA-1594-2022
FU Indian Council of Medical Research; University of Delhi
FX The authors express their gratitude to the Indian Council of Medical
   Research for fellowship to AS which helped in funding the present study.
   We are thankful to Institute of Eminence, University of Delhi for
   funding the fieldwork of the study. We are thankful to the participants
   who cooperated with the research team.
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NR 83
TC 0
Z9 0
U1 1
U2 1
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1742-4755
J9 REPROD HEALTH
JI Reprod. Health
PD APR 28
PY 2025
VL 22
IS 1
AR 61
DI 10.1186/s12978-025-02019-9
PG 12
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA 2AO7J
UT WOS:001478076500001
PM 40296029
DA 2025-06-11
ER

PT J
AU Al Kudsee, K
   Vahid, F
   Bohn, T
   ORISCAV Working Grp
AF Al Kudsee, Kinda
   Vahid, Farhad
   Bohn, Torsten
   ORISCAV Working Grp
TI High adherence to the Mediterranean diet and Alternative Healthy Eating
   Index are associated with reduced odds of metabolic syndrome and its
   components in participants of the ORISCAV-LUX2 study
SO FRONTIERS IN NUTRITION
LA English
DT Article
DE inflammation; oxidative stress; heart disease; type 2 diabetes;
   hypertension; dietary indices
ID BLOOD-PRESSURE; CARDIOVASCULAR RISK; QUALITY INDEXES; METAANALYSIS;
   PATTERNS; HYPERTENSION; CONSUMPTION; POPULATION; SURVIVAL; SCORE
AB BackgroundMetabolic syndrome (MetS) is a major risk factor for cardiometabolic complications. Certain dietary patterns play a pivotal role in improving MetS components. The aim of this investigation was to study associations between the Mediterranean Diet Score (MDS) and the Alternative Healthy Eating Index (AHEI) and the odds of MetS and its components in adults living in Luxembourg. MethodsData from 1,404 adults participating in the cross-sectional ORISCAV-LUX2 study were analyzed by a self-reported questionnaire, anthropometric measures, a food frequency questionnaire (174 items), and blood/urine samples. ResultsA significant association of dietary indices and MetS was not found except when expressing MetS as a score (continuous variable, log-transformed), based on the weighting of compounds using exploratory factor analysis with the MDS (beta = -0.118, 95% CI: -0.346, -0.120) and AHEI (beta = -0.133, 95% CI: -0.059, -0.019). Fully adjusted linear regression models further showed significant inverse associations between components of MetS and MDS (all as log-transformed variables), including body mass index (BMI) (beta = -0.0067, 95% CI: -0.0099, -0.0036), waist-circumference (WC) (beta = -0.0048, 95% CI: -0.0072, -0.0024), systolic blood pressure (SBP) (beta = -0.0038, 95% CI: -0.0061, -0.0016), and diastolic blood pressure (DBP) (beta = -0.0035, 95% CI: -0.0060, -0.0009). Similarly, significant inverse associations between AHEI and components of MetS (log-transformed) included BMI (beta = -0.0001, 95% CI: -0.0016, -0.0002), WC (beta = -0.0007, 95% CI: -0.0011, -0.0002), SBP (beta = -0.0006, 95% CI: -0.0010, -0.0002), and DBP (beta = -0.0006, 95% CI: -0.0011, -0.0001). ConclusionHigher adherence to a Mediterranean diet and following healthy eating guidelines were associated with reduced odds of MetS and several of its components in Luxembourgish residents, highlighting that balanced and healthy eating patterns are a crucial cornerstone in the fight against MetS.
C1 [Al Kudsee, Kinda; Vahid, Farhad; Bohn, Torsten; ORISCAV Working Grp] Luxembourg Inst Hlth, Dept Precis Hlth, Nutr & Hlth Res Grp, Strassen, Luxembourg.
C3 Luxembourg Institute of Health
RP Bohn, T (corresponding author), Luxembourg Inst Hlth, Dept Precis Hlth, Nutr & Hlth Res Grp, Strassen, Luxembourg.
EM Torsten.bohn@lih.lu
RI Bohn, Torsten/AAE-8393-2019; Vahid, Farhad/L-7547-2018
OI Bohn, Torsten/0000-0002-7825-0697; Alkoudsi / Al Kudsee,
   kinda/0000-0002-5056-5849; Vahid, Farhad/0000-0002-7380-3790
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PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD DEC 13
PY 2022
VL 9
AR 1087985
DI 10.3389/fnut.2022.1087985
PG 17
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 7G3PQ
UT WOS:000902441200001
PM 36583217
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Torres, MCP
   Bodini, G
   Furnari, M
   Marabotto, E
   Zentilin, P
   Giannini, EG
AF Plaz Torres, Maria Corina
   Bodini, Giorgia
   Furnari, Manuele
   Marabotto, Elisa
   Zentilin, Patrizia
   Giannini, Edoardo G.
TI Nuts and Non-Alcoholic Fatty Liver Disease: Are Nuts Safe for Patients
   with Fatty Liver Disease?
SO NUTRIENTS
LA English
DT Review
DE steatosis; steatohepatitis; liver disease; hepatocellular carcinoma;
   aflatoxin; peanuts
ID AFLATOXIN B-1 HEPATOTOXICITY; CAUSE-SPECIFIC MORTALITY; MEDITERRANEAN
   DIET; METABOLIC SYNDROME; CONSUMPTION; RISK; EXPOSURE; METAANALYSIS;
   ALMONDS; FOOD
AB Diet and lifestyle interventions are the recommended treatment for patients with non-alcoholic fatty liver disease (NAFLD), with the aim of achieving a 7-10% weight loss. Several dietary patterns have been suggested for this purpose, however, to date, the best one is represented by the Mediterranean diet (MD) as it is rich in macro- and micro- nutrients known for their effectiveness in health-promotion and cardio-vascular disease prevention. Moreover, MD is characterized by the inclusion of nuts. These foods have shown potential benefits in health-promotion as they are rich in fibers, which have lipid-lowering effects, rich in mono- and poly-unsaturated fatty acids, which help reduce insulin-resistance and serum cholesterol, and contain anti-oxidants which reduce oxidative stress and inflammation. Additionally, nuts are associated with a better control, or reduction, of Body Mass Index (BMI). All these effects are useful targets to achieve in NAFLD, so that nuts have been proposed as a suitable dietary treatment supplement for weight and metabolic control in these patients. In recent years, health authorities raised an alert on nuts consumption as these may be at high risk of aflatoxin (AF) contamination, for which controls and legislations are different among countries. AF is a well-known cancerogenic agent and a recognized risk factor for hepatocellular carcinoma. Patients with NAFLD have an overall, inherent sevenfold increased risk of developing hepatocellular carcinoma as compared with the general population. In this context, one could argue that recommending the inclusion of nuts in the diet of NAFLD patients has to be balanced with the risk of potential chronic exposure to AF, and every effort should be pursued to assure the safety of these nutrients. In this review, we aim to summarize the benefits of nuts consumption, the evidence for AF contamination of nuts and the consequent potential risks in patients with NAFLD.
C1 [Plaz Torres, Maria Corina; Bodini, Giorgia; Furnari, Manuele; Marabotto, Elisa; Zentilin, Patrizia; Giannini, Edoardo G.] Univ Genoa, Dept Internal Med, Gastroenterol Unit, IRCCS Osped Policlin San Martino, I-16132 Genoa, Italy.
C3 University of Genoa; IRCCS AOU San Martino IST
RP Giannini, EG (corresponding author), Univ Genoa, Dept Internal Med, Gastroenterol Unit, IRCCS Osped Policlin San Martino, I-16132 Genoa, Italy.
EM maco.plaz87@gmail.com; giorgia.bodini@unige.it;
   manuele.furnari@unige.it; elisa.marabotto@unige.it; pzentilin@unige.it;
   egiannini@unige.it
RI Zentilin, Patrizia/AAH-4451-2020; Torres, Maria/JBI-9165-2023; Furnarl,
   Manuele/N-5545-2015; Marabotto, Elisa/AAB-2874-2021; Giannini,
   Edoardo/E-1120-2012; Bodini, Giorgia/AAC-2888-2019
OI Giannini, Edoardo/0000-0001-8526-837X; Bodini,
   Giorgia/0000-0002-8367-0338
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NR 100
TC 20
Z9 21
U1 0
U2 11
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD NOV
PY 2020
VL 12
IS 11
AR 3363
DI 10.3390/nu12113363
PG 15
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA OX7RW
UT WOS:000593758300001
PM 33139607
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Jerez-Roig, J
   Booth, J
   Skelton, DA
   Giné-Garriga, M
   Chastin, SFM
   Hagen, S
AF Jerez-Roig, Javier
   Booth, Joanne
   Skelton, Dawn A.
   Gine-Garriga, Maria
   Chastin, Sebastien F. M.
   Hagen, Suzanne
TI Is urinary incontinence associated with sedentary behaviour in older
   women? Analysis of data from the National Health and Nutrition
   Examination Survey
SO PLOS ONE
LA English
DT Article
ID OVERACTIVE BLADDER; METABOLIC SYNDROME; LIFE-STYLE; OBESITY; RISK;
   PREVALENCE; FRAILTY; SCIENCE; TRACT; LINK
AB Background
   Urinary incontinence (UI) is a common geriatric syndrome associated with physical and cognitive impairments. The association between type of UI and sedentary behaviour (SB) has not been explored.
   Aim
   To determine association between moderate-severe UI, or any stress UI (SUI) or any urgency UI (UUI) and SB in community-dwelling older women.
   Methods
   Women aged 60 and over from the 2005-2006 cycle of the National Health and Nutrition Examination Survey (NHANES) with objectively measured (accelerometer) and selfreported SB and UI data were selected. Multivariate models exploring association between moderate-severe UI and SB, or SUI and SB, or UUI and SB were analysed using logistic regression adjusted for factors associated with UI.
   Results
   In the overall sample of 459 older women, 23.5% reported moderate-severe UI, 50.5% reported any SUI and 41.4% reported any UUI. In bivariate analysis objectively measured proportion of time in SB was associated with moderate-severe UI and UUI (p = 0.014 and p = 0.047) but not SUI. Average duration of SB bouts in those with moderate-severe UI or any SUI was no longer than older women reporting no continence issues, but it was significantly (19%) longer in older women with any UUI (mean difference 3.2 minutes; p = 0.001). Selfreported SB variables were not associated with any type of UI. Multivariate analysis showed an association between UUI and a longer average duration of SB bouts (OR = 1.05, 95% CI = 1.01-1.09, p = 0.006) but no association with moderate-severe UI or SUI.
   Conclusion
   UUI was significantly associated with increased average duration of SB bouts in communitydwelling older women. The importance of objective measurement of SB is highlighted and suggests that decreasing time in prolonged sitting may be a target intervention to reduce UUI. Future studies are required to further explore the association between SB and incontinence.
C1 [Jerez-Roig, Javier] Cent Univ Catalonia UVic UCC, Res Grp Methodol Methods Models & Outcomes Hlth &, Fac Hlth Sci & Welf, Ctr Hlth & Social Care Res CESS,Univ Vic, Vic, Spain.
   [Booth, Joanne; Skelton, Dawn A.; Gine-Garriga, Maria; Chastin, Sebastien F. M.] Glasgow Caledonian Univ, Sch Hlth & Life Sci, Glasgow, Lanark, Scotland.
   [Gine-Garriga, Maria] Ramon Llull Univ, Blanquerna Fac Psychol Educ & Sport Sci, Barcelona, Spain.
   [Chastin, Sebastien F. M.] Univ Ghent, Dept Sport & Movement Sci, Ghent, Belgium.
   [Hagen, Suzanne] Glasgow Caledonian Univ, Nursing Midwifery & Allied Hlth Profess Res Unit, Glasgow, Lanark, Scotland.
C3 Universitat de Vic - Universitat Central de Catalunya (UVic-UCC);
   Glasgow Caledonian University; Universitat Ramon Llull; Ghent
   University; Glasgow Caledonian University
RP Jerez-Roig, J (corresponding author), Cent Univ Catalonia UVic UCC, Res Grp Methodol Methods Models & Outcomes Hlth &, Fac Hlth Sci & Welf, Ctr Hlth & Social Care Res CESS,Univ Vic, Vic, Spain.
EM javier.jerez@uvic.cat
RI HAGEN, SUZANNE/LIH-4781-2024; Giné-Garriga, Maria/AAF-9828-2019;
   Chastin, Sebastien/ABF-1455-2020; Skelton, Dawn/B-7552-2013; Jerez-Roig,
   Javier/V-6119-2018
OI Gine-Garriga, Maria/0000-0003-4449-3524; Chastin,
   Sebastien/0000-0003-1421-9348; HAGEN, SUZANNE/0000-0002-9741-9160;
   Skelton, Dawn A/0000-0001-6223-9840; Booth, Joanne/0000-0002-7870-6391;
   Jerez-Roig, Javier/0000-0002-1968-4452
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NR 34
TC 16
Z9 17
U1 0
U2 5
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD FEB 4
PY 2020
VL 15
IS 2
AR e0227195
DI 10.1371/journal.pone.0227195
PG 13
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA LP9EF
UT WOS:000534618100009
PM 32017767
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Mazidi, M
   Rezaie, P
   Banach, M
AF Mazidi, Mohsen
   Rezaie, Peyman
   Banach, Maciej
CA Lipid & Blood Pressure Meta Anal
TI Effect of magnesium supplements on serum C-reactive protein: a
   systematic review and meta-analysis
SO ARCHIVES OF MEDICAL SCIENCE
LA English
DT Review
DE meta-analysis; magnesium; C-reactive protein
ID DIETARY MAGNESIUM; ENDOTHELIAL DYSFUNCTION; METABOLIC SYNDROME;
   DOUBLE-BLIND; INFLAMMATION; HYPOMAGNESEMIA; DECREASES; STRESS; OLDER;
   RISK
AB Introduction: The aim of the study was to undertake a systematic review and meta-analysis of prospective studies to determine the effect of magnesium (Mg) supplementation on C-reactive protein (CRP). Design: Systematic review and meta-analysis of randomised controlled trials (RCTs).
   Material and methods: Data sources: PubMed-Medline, Web of Science, Cochrane Database, and Google Scholar databases were searched (up until December 2016). Eligibility criteria: Randomized controlled trials evaluating the impact of Mg supplementation on CRP. We used random effects models meta-analysis for quantitative data synthesis. For sensitivity analysis was used the leave-one-out method. Heterogeneity was quantitatively assessed using the I-2 index.Main outcome: Level of CRP after Mg supplementation.
   Results: From a total of 96 entries identified via searches, eight studies were included in the final selection. The meta-analysis indicated a significant reduction in serum CRP concentrations following Mg supplementation (weighted mean difference (WMD) -1.33 mg/l; 95% CI: -2.63 to -0.02, heterogeneity p < 0.123; I-2 = 29.1%). The WMD for interleukin 6 was - 0.16 pg/dl (95% CI: -3.52 to 3.26, heterogeneity p = 0.802; I-2 = 2.3%), and 0.61 mg/dl (95% CI: -2.72 to 1.48, p = 0.182, heterogeneity p = 0.742; I-2 = 6.1%) for fasting blood glucose. These findings were robust in sensitivity analyses. Random-effects meta-regression revealed that changes in serum CRP levels were independent of the dosage of Mg supplementation (slope: -0.004; 95% CI: - 0.03, 0.02; p = 0.720) or duration of follow-up (slope: -0.06; 95% CI: -0.37, 0.24; p = 0.681).
   Conclusions: This meta-analysis suggests that Mg supplementation significantly reduces serum CRP level. RCTs with a larger sample size and a longer follow-up period should be considered for future investigations to give an unequivocal answer.
C1 [Mazidi, Mohsen] Chinese Acad Sci, Inst Genet & Dev Biol, Key State Lab Mol Dev Biol, Beijing, Peoples R China.
   [Mazidi, Mohsen] Univ Chinese Acad Sci IC UCAS, Int Coll, Inst Genet & Dev Biol, West Beichen Rd, Chaoyang, Peoples R China.
   [Rezaie, Peyman] Mashhad Univ Med Sci, Sch Med, Biochem & Nutr Res Ctr, Mashhad, Iran.
   [Banach, Maciej] Med Univ Lodz, Chair Nephrol & Hypertens, Dept Hypertens, Lodz, Poland.
   [Banach, Maciej] PMMHRI, Lodz, Poland.
   [Banach, Maciej] Univ Zielona Gora, Cardiovasc Res Ctr, Zielona Gora, Poland.
C3 Chinese Academy of Sciences; Institute of Genetics & Developmental
   Biology, CAS; Chinese Academy of Sciences; Institute of Genetics &
   Developmental Biology, CAS; University of Chinese Academy of Sciences,
   CAS; Mashhad University of Medical Sciences; Medical University Lodz;
   University of Zielona Gora
RP Mazidi, M (corresponding author), Chinese Acad Sci, Inst Genet & Dev Biol, Key State Lab Mol Dev Biol, Beijing, Peoples R China.
EM moshen@genetics.ac.cn
RI Rezaie, Peyman/GMX-3967-2022; Linn, Shai/N-3079-2019; Banach,
   Maciej/A-1271-2009
OI Banach, Maciej/0000-0001-6690-6874
FU TWAS studentship of the Chinese Academy of Sciences
FX MM was supported by a TWAS studentship of the Chinese Academy of
   Sciences, during the preparation of this manuscript.
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NR 45
TC 62
Z9 65
U1 1
U2 6
PU TERMEDIA PUBLISHING HOUSE LTD
PI POZNAN
PA KLEEBERGA ST 2, POZNAN, 61-615, POLAND
SN 1734-1922
EI 1896-9151
J9 ARCH MED SCI
JI Arch. Med. Sci.
PD JUN
PY 2018
VL 14
IS 4
BP 707
EP 716
DI 10.5114/aoms.2018.75719
PG 10
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA GK7FI
UT WOS:000436361500001
PM 30002686
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Park, JA
   Lee, JH
   Lee, HJ
   Jin, BH
   Bae, KH
AF Park, Ji-A
   Lee, Jung-Hwa
   Lee, Hyo-Jin
   Jin, Bo-Hyoung
   Bae, Kwang-Hak
TI Association of Some Vitamins and Minerals with Periodontitis in a
   Nationally Representative Sample of Korean Young Adults
SO BIOLOGICAL TRACE ELEMENT RESEARCH
LA English
DT Article
DE Niacin; vitamin C; iron; periodontitis; association
ID OXIDATIVE STRESS; NICOTINIC-ACID; METABOLIC SYNDROME; DISEASE;
   SUPPLEMENTATION; HEALTH; SERUM; OLDER
AB The purpose of this study was to investigate whether the intakes of some kinds of vitamins and minerals are associated with periodontitis in a nationally representative sample of young adults. This study comprised 2049 young adults aged 19-39 years who took both periodontal examination and nutrition survey. The vitamin and mineral intakes were calculated from dietary intake data gained by complete one-day 24-h recall interviews, and the intake levels for each nutrient were classified by the Recommended Nutrient Intake (RNI) in Dietary Reference Intakes for Koreans and median values. Periodontitis was assessed using Community Periodontal Index (CPI). Multivariate logistic regression analyses were performed in a whole sample and subgroups with the strata of gender or smoking, following a complex sampling design. In analyses according to RNI, a lower intake of niacin was significantly associated with periodontitis in young adults (odd ratio [OR] 1.47, 95% confidential interval [CI] 1.09-2.00) and in its subgroup of women (OR 1.70; 95% CI 1.10-2.64) and current non-smokers (OR 1.75; 95% CI 1.22-2.51). Whereas, in analyses according to median intake values, there were significant associations of periodontitis with a lower intake of niacin in women (OR 1.58; 95% CI 1.02-2.46) and current non-smokers (OR 1.50; 95% CI 1.01-2.22), with lower intake of vitamin C in women (OR 1.66; 95% CI 1.04-2.64) and in current non-smokers (OR 1.49; 95% CI 1.04-2.14), with lower intake of iron in women (OR 1.85; 95% CI 1.11-3.07), and with lower intake of vitamin A marginally in women (OR 1.56; 95% CI 1.00-2.44). In young adults, periodonitis is significantly associated with the lower intakes of niacin, vitamin C, and iron, especially in women and current non-smokers.
C1 [Park, Ji-A; Lee, Hyo-Jin; Jin, Bo-Hyoung] Seoul Natl Univ, Sch Dent, Dept Prevent & Publ Hlth Dent, Seoul, South Korea.
   [Park, Ji-A; Lee, Hyo-Jin; Jin, Bo-Hyoung] Seoul Natl Univ, Dent Res Inst, Sch Dent, Seoul, South Korea.
   [Lee, Jung-Hwa] Dong Eui Univ, Dept Dent Hyg, Coll Nursing & Healthcare Sci, Busan, South Korea.
   [Bae, Kwang-Hak] Apple Tree Dent Hosp, Oral Hlth Sci Res Ctr, Jungang Ro 1573, Goyang Si 10381, Gyounggi Do, South Korea.
C3 Seoul National University (SNU); Seoul National University (SNU);
   Dong-Eui University
RP Bae, KH (corresponding author), Apple Tree Dent Hosp, Oral Hlth Sci Res Ctr, Jungang Ro 1573, Goyang Si 10381, Gyounggi Do, South Korea.
EM baekh@snu.ac.kr
RI jin, bo-hyoung/AAU-8576-2021
OI Lee, Hyo-Jin/0000-0002-3465-1747; PARK, JI-A/0000-0002-7397-5701
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NR 44
TC 24
Z9 25
U1 0
U2 10
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0163-4984
EI 1559-0720
J9 BIOL TRACE ELEM RES
JI Biol. Trace Elem. Res.
PD AUG
PY 2017
VL 178
IS 2
BP 171
EP 179
DI 10.1007/s12011-016-0914-x
PG 9
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA FA5IG
UT WOS:000405475800001
PM 28035581
DA 2025-06-11
ER

PT J
AU Abu-Farha, M
   Cherian, P
   Al-Khairi, I
   Madhu, D
   Tiss, A
   Warsam, S
   Alhubail, A
   Sriraman, D
   Al-Refaei, F
   Abubaker, J
AF Abu-Farha, Mohamed
   Cherian, Preethi
   Al-Khairi, Irina
   Madhu, Dhanya
   Tiss, Ali
   Warsam, Samia
   Alhubail, Asma
   Sriraman, Devarajan
   Al-Refaei, Faisal
   Abubaker, Jehad
TI Plasma and adipose tissue level of angiopoietin-like 7 (ANGPTL7) are
   increased in obesity and reduced after physical exercise
SO PLOS ONE
LA English
DT Article
ID METABOLIC SYNDROME; OXIDATIVE STRESS; BETATROPHIN/ANGPTL8 LEVEL;
   TRIGLYCERIDE-METABOLISM; CALORIC RESTRICTION; HEMATOPOIETIC STEM;
   LIPOPROTEIN-LIPASE; LIPID-METABOLISM; PROTEINS 3; INFLAMMATION
AB Objective
   ANGPTL7 is a member of the Angiopoietin- like (ANGPTL) protein family that is composed of eight proteins (1-8). Increasing evidence is associating ANGPTL proteins to obesity and insulin resistance. The biological role of ANGPTL7 is yet to be understood except for a recently proposed role in the pathophysiology of glaucoma. This study was designed to shed light on the function of ANGPTL7 in obesity and its modulation by physical exercise as well as its potential association with lipid profile.
   Methods
   A total of 144 subjects were enrolled in this study and finished three months of physical exercise. The participants were classified based on their BMI, 82 subjects were non-obese and 62 obese. ANGPTL7 levels in plasma and adipose tissue were measured by ELISA, RTPCR and immunohistochemistry.
   Results
   In this study, we showed that ANGPTL7 level was increased in the plasma of obese subjects (1249.05 +/- 130.39 pg/mL) as compared to non-obese (930.34 +/- 87.27 pg/mL) (p-Value = 0.032). ANGPTL7 Gene and protein expression levels in adipose tissue also showed over two fold increase. Physical exercise reduced circulating level of ANGPTL7 in the obese subjects to 740.98 +/- 127.18 pg/mL, (p-Value = 0.007). ANGPTL7 expression in adipose tissue was also reduced after exercise. Finally, ANGPTL7 circulating level showed significant association with TG level in the obese subjects (R-2 = 0.183, p-Value = 0.03).
   Conclusion
   In conclusion, our data shows for the first time that obesity increases the level of ANGPTL7 in both plasma and adipose tissue. Increased expression of ANGPTL7 might play a minor role in the regulation of TG level in obese subjects either directly or through interaction with other ANGPTL protein members. Physical exercise reduced the level of ANGPTL7 highlighting the potential for targeting this protein as a therapeutic target for regulating dyslipidemia.
C1 [Abu-Farha, Mohamed; Cherian, Preethi; Al-Khairi, Irina; Madhu, Dhanya; Tiss, Ali; Warsam, Samia; Abubaker, Jehad] Dasman Diabet Inst, Biochem & Mol Biol Unit, Kuwait, Kuwait.
   [Alhubail, Asma; Al-Refaei, Faisal] Dasman Diabet Inst, Clin Serv Dept, Kuwait, Kuwait.
   [Sriraman, Devarajan] Dasman Diabet Inst, Tissue Banking Unit, Kuwait, Kuwait.
C3 Dasman Diabetes Institute (DDI); Dasman Diabetes Institute (DDI); Dasman
   Diabetes Institute (DDI)
RP Abubaker, J (corresponding author), Dasman Diabet Inst, Biochem & Mol Biol Unit, Kuwait, Kuwait.
EM mohamed.abufarha@dasmaninstitute.org; jehad.abubakr@dasmaninstitute.org
RI Abubaker, Jehad/KHV-9373-2024; Tiss, Ali/L-6656-2019; Abu-Farha,
   Mohamed/KHW-8579-2024
OI Abubaker, Jehad/0000-0003-0681-7305; madhu, Dhanya/0009-0006-2501-542X;
   Cherian, Preethi/0000-0002-2132-3533; Tiss, Ali/0000-0002-3024-5370;
   Abu-Farha, Mohamed/0000-0001-8357-1252
FU Kuwait Foundation for the Advancement of Sciences (KFAS) [RA-2016-025]
FX This work was supported by Kuwait Foundation for the Advancement of
   Sciences (KFAS).We are grateful to Clinical Laboratory and the Tissue
   Bank Core Facility at DDI for their contribution in handling samples. We
   are also indebted to Kuwait Foundation for the Advancement of Sciences
   (KFAS) for financial support of this research project (RA-2016-025). The
   funding agency was not involved in data collection, analysis, or
   interpretation; trial design; patient recruitment; or any aspect
   pertinent to the study. Special thanks to Dr. Veeramani Marimuthu for
   his help in accessing journal articles used in this study. The
   corresponding authors had full access to all the data in the study and
   had final responsibility for the decision to submit for publication.
   None of the authors have been paid to write this article by a
   pharmaceutical company or other agency. Due to institute policy as well
   as the ethical review board where they restrict sharing such data in a
   public domain, data are available upon request. This data will be
   available through direct requisition by contacting Dr. Mohamed Abu-Farha
   or Dr. Jehad Abubaker. Approval to access data is to be addressed to the
   Chairman of the Ethical Review Committee Dr. Abdullah Bennakhi,
   (abdullah.bennakhi@dasmaninstitute.org).
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NR 67
TC 20
Z9 24
U1 0
U2 10
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAR 6
PY 2017
VL 12
IS 3
AR e0173024
DI 10.1371/journal.pone.0173024
PG 16
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA EN5OE
UT WOS:000396054300035
PM 28264047
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Nielsen, FH
AF Nielsen, Forrest H.
TI Importance of plant sources of magnesium for human health
SO CROP & PASTURE SCIENCE
LA English
DT Article
ID C-REACTIVE PROTEIN; PLACEBO-CONTROLLED TRIAL; LOW SERUM MAGNESIUM;
   DIETARY MAGNESIUM; METABOLIC SYNDROME; CARDIOVASCULAR-DISEASE; OBESE
   SUBJECTS; US ADULTS; SUPPLEMENTATION IMPROVES; ATHEROSCLEROSIS-RISK
AB Based on established dietary reference intakes (DRIs) (e.g. estimated average requirements, recommended dietary allowances (RDAs), and reference nutrient intakes), magnesium (Mg) deficiency in the range 50-99% of the requirement commonly occurs throughout the world. Yet, Mg is not often considered a major nutrient of concern for health and wellbeing, although deficient intakes and serum concentrations have been associated with numerous pathological conditions including atherosclerosis, diabetes, osteoporosis and some cancers. Probable reasons for this dichotomy are that evidence of Mg deficiency is not consistently found in pathological conditions with which it has been associated, and not all individuals considered Mg-deficient consistently exhibit these pathological conditions. These inconsistencies could be the outcome of chronic inflammatory stress exacerbated or induced by Mg deficiency being alleviated or prevented by other factors that have anti-inflammatory action (e.g. long-chain n-3 fatty acids). Questionable DRIs resulting in the incorrect conclusion that individuals are Mg-deficient when they are not also may be responsible for the inconsistencies. Since 1997, improved balance data have been reported for the determination of DRIs, which suggest that the RDA for a 70-kg healthy adult would be similar to 250 mg day(-1). Based on the finding that neutral Mg balance was determined to be 2.36 mg day(-1) kg(-1) bodyweight, the RDA would vary by bodyweight. Even with changed DRIs, a significant number of adults who do not eat recommended amounts of foods of plant origin would not achieve the suggested adequate intake of Mg. Foods of plant origin, including green vegetables, nuts, pulses and whole grains, are good sources of Mg. However, Mg in these foods can be influenced by the availability of Mg to plants from the soil, and plant genotype. Thus, crop breeding and cultural practices, through modifying the amount of Mg in plant-origin foods, can have a significant impact on achieving an adequate dietary intake of Mg for health.
C1 [Nielsen, Forrest H.] ARS, USDA, Grand Forks Human Nutr Res Ctr, Grand Forks, ND 58202 USA.
C3 United States Department of Agriculture (USDA)
RP Nielsen, FH (corresponding author), ARS, USDA, Grand Forks Human Nutr Res Ctr, 2420 2nd Ave N,Stop 9034, Grand Forks, ND 58202 USA.
EM forrest.nielsen@ars.usda.gov
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NR 66
TC 16
Z9 18
U1 0
U2 22
PU CSIRO PUBLISHING
PI CLAYTON
PA UNIPARK, BLDG 1, LEVEL 1, 195 WELLINGTON RD, LOCKED BAG 10, CLAYTON, VIC
   3168, AUSTRALIA
SN 1836-0947
EI 1836-5795
J9 CROP PASTURE SCI
JI Crop Pasture Sci.
PY 2015
VL 66
IS 12
BP 1259
EP 1264
DI 10.1071/CP15072
PG 6
WC Agriculture, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture
GA CZ7GF
UT WOS:000367267200007
DA 2025-06-11
ER

PT J
AU Casteràs, A
   Fidilio, E
   Comas, M
   Zabalegui, A
   Flores, V
   Giralt, M
   Díaz-Troyano, N
   Ferrer, R
   Vilallonga, R
   Ciudin, A
   Biagetti, B
AF Casteras, Anna
   Fidilio, Enzamaria
   Comas, Marta
   Zabalegui, Alba
   Flores, Vanesa
   Giralt, Marina
   Diaz-Troyano, Noelia
   Ferrer, Roser
   Vilallonga, Ramon
   Ciudin, Andreea
   Biagetti, Betina
TI Pre-Surgery Cortisol Levels as Biomarker of Evolution after Bariatric
   Surgery: Weight Loss and Weight Regain
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Article
DE dexamethasone suppression test; DST 1 mg; morning serum cortisol;
   bariatric surgery; weight regain; weight loss; severe obesity
ID BODY-FAT DISTRIBUTION; GASTRIC BYPASS; METABOLIC SYNDROME; ABDOMINAL
   OBESITY; CUSHINGS-SYNDROME; 1 MG; STRESS; DEXAMETHASONE; PREDICTORS;
   SECRETION
AB Background: Bariatric surgery (BS) is effective for achieving significant weight loss. However, weight regain (WR) is an emerging problem. Objective: To assess the prognostic value of morning serum cortisol, a 1 mg dexamethasone suppression test (DST), 24 h urinary free cortisol (UFC) and late-night salivary cortisol (LNSC) in a cohort of patients with severe obesity (pwSO) undergoing BS in terms of weight loss and WR. Methods: Patients scheduled for BS underwent the following procedures at baseline, 12 months and 24 months after BS: medical history, anthropometric data, blood analysis and cortisol tests. We evaluated total weight loss (TWL) >= 30% at 1 year and WR after 2 years as an increase of >= 10% of the maximum weight lost. Results: In total, 142 subjects were included; 101 (71.1%) were females and the mean age was 45.9 +/- 9.2 years. Up to 76.8% of subjects achieved >= 30% TWL, without statistically significant differences in DST results or morning serum cortisol, UFC or LNSC levels. However, a higher pre-surgery morning serum cortisol level was a significant predictor of a WR >= 10% (cortisol 17.8 [IQR 13.1-18.5] vs. 12.0 [IQR 8.8-15.8] mu g/dL; p < 0.01); OR of 1.216 (95% CI 1.069-1.384); AUC [0.761, CI: (0.616-0.906); p < 0.01]. A cut-off value of cortisol > 13.0 mu g/dL was predictive of a WR >= 10% (sensitivity 0.71; specificity 0.63). Conclusions: No cortisol test was useful in predicting weight loss; however, the pre-surgery morning serum cortisol level was able to predict a WR >= 10% in a cohort of pwSO 2 years after BS. A cut-off value of cortisol > 13 mu g/dL might be an easy tool to identify patients at higher risk of WR, enabling healthcare providers to implement tailored, long-term strategies to minimize this outcome.
C1 [Casteras, Anna; Fidilio, Enzamaria; Comas, Marta; Zabalegui, Alba; Flores, Vanesa; Ciudin, Andreea; Biagetti, Betina] Hosp Univ Vall dHebron, Endocrinol & Nutr Dept, Passeig Vall dHebron 119-121, Barcelona 08035, Spain.
   [Casteras, Anna; Ferrer, Roser; Vilallonga, Ramon; Ciudin, Andreea; Biagetti, Betina] Univ Autonoma Barcelona, Dept Med, Cerdanyola Del Valles 08193, Barcelona, Spain.
   [Casteras, Anna; Fidilio, Enzamaria; Comas, Marta; Ciudin, Andreea; Biagetti, Betina] Vall dHebron Inst Recerca, Diabet & Metab Res Unit, Barcelona 08035, Spain.
   [Giralt, Marina; Diaz-Troyano, Noelia; Ferrer, Roser] Hosp Univ Vall dHebron, Biochem Dept, Barcelona 08035, Spain.
   [Vilallonga, Ramon] Hosp Univ Vall dHebron, Gen Surg Dept, Endocrine Metab & Bariatr Unit, Barcelona 08035, Spain.
C3 Hospital Universitari Vall d'Hebron; Autonomous University of Barcelona;
   Autonomous University of Barcelona; Hospital Universitari Vall d'Hebron;
   Vall d'Hebron Institut de Recerca (VHIR); Hospital Universitari Vall
   d'Hebron; Hospital Universitari Vall d'Hebron
RP Biagetti, B (corresponding author), Hosp Univ Vall dHebron, Endocrinol & Nutr Dept, Passeig Vall dHebron 119-121, Barcelona 08035, Spain.; Biagetti, B (corresponding author), Univ Autonoma Barcelona, Dept Med, Cerdanyola Del Valles 08193, Barcelona, Spain.; Biagetti, B (corresponding author), Vall dHebron Inst Recerca, Diabet & Metab Res Unit, Barcelona 08035, Spain.
EM anna.casteras@vallhebron.cat; enzamaria.fidilio@vallhebron.cat;
   marta.comas@vallhebron.cat; alba.zabalegui@vallhebron.cat;
   vanesapaola.flores@vallhebron.cat; marina.giralt@vallhebron.cat;
   noelia.diaz@vallhebron.cat; roser.ferrer@vallhebron.cat;
   ramon.vilallonga@vallhebron.cat; andreea.ciudin@vallhebron.cat;
   betinaloys.biagetti@vallhebron.cat
RI VILALLONGA, RAMON/AAO-5437-2020; CIUDIN, ANDREEA/O-5250-2016; Biagetti,
   Betina/L-4269-2018
OI Comas Martinez, Marta/0000-0002-1511-5447; Biagetti,
   Betina/0000-0002-8837-4343; Ferrer Costa, Roser/0000-0002-8925-3172;
   Diaz-Troyano, Noelia/0000-0002-9392-0142; VILALLONGA,
   RAMON/0000-0001-9333-2765
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NR 70
TC 2
Z9 2
U1 3
U2 3
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD SEP
PY 2024
VL 13
IS 17
AR 5146
DI 10.3390/jcm13175146
PG 13
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA F8I1P
UT WOS:001312179100001
PM 39274358
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Kelem, A
   Shiferaw, E
   Adane, T
AF Kelem, Amanuel
   Shiferaw, Elias
   Adane, Tiruneh
TI Hematological abnormalities and associated factors among metabolic
   syndrome patients at the University of Gondar comprehensive specialized
   hospital, Northwest Ethiopia
SO PLOS ONE
LA English
DT Article
ID BLOOD-CELL COUNT; INSULIN-RESISTANCE; DIABETES-MELLITUS; OXIDATIVE
   STRESS; PLATELET COUNT; RISK-FACTOR; ANEMIA; PARAMETERS; COMPONENTS;
   PREVALENCE
AB BackgroundMetabolic Syndrome (MetS) is a cluster of interconnected metabolic diseases. Hematological abnormalities are common but neglected complications of MetS. Thus, this study aimed to determine the magnitude of hematological abnormalities and their associated factors among MetS patients at the University of Gondar comprehensive specialized hospital, Northwest Ethiopia. MethodA hospital-based cross-sectional study was conducted at the University of Gondar comprehensive specialized hospital from March to May 2022. A total of 384 MetS patients were selected using a systematic random sampling technique. Data were collected using pre-tested structured questionnaires and checklists. Anthropometric and blood pressure measurements were taken, and blood sample was collected for complete blood count determination. Stool and blood film examinations were performed to detect intestinal and malaria parasites, respectively. Data were entered into EpiData 3.1 and analyzed by Stata 14.0 software. Bivariate and multivariate logistic regression models were fitted to identify factors associated with hematological abnormalities. A p-value of < 0.05 was considered statistically significant. ResultsThe magnitude of anemia, leukopenia, leukocytosis, thrombocytopenia, and thrombocytosis was found to be 13.3%, 0.5%, 2.9%, 1.6%, and 2.3%, respectively. Being male (AOR = 2.65, 95% CI: 1.14, 6.20), rural residency (AOR = 5.79, 95% CI: 1.72, 19.51), taking antihypertensive medications (AOR = 3.85, 95% CI: 1.16, 12.78), having elevated triglyceride level (AOR = 2.21, 95% CI: 1.03, 4.75), and being overweight or obese (AOR = 0.32, 95% CI: 0.16, 0.64) were significantly associated with anemia. ConclusionsAnemia was the most prevalent hematological abnormality identified in the present study, followed by leukocytosis and thrombocytosis. Anemia was a mild public health problem among MetS patients in the study area. Routine anemia screening for all MetS patients, especially for those with significant associated factors, may help in the early detection and effective management of anemia, which subsequently improves the patients' quality of life.
C1 [Kelem, Amanuel] Debre Berhan Univ, Dept Med Lab Sci, Asrat Woldeyes Hlth Sci Campus, Debre Berhan, Ethiopia.
   [Shiferaw, Elias; Adane, Tiruneh] Univ Gondar, Coll Med & Hlth Sci, Sch Biomed & Lab Sci, Dept Hematol & Immunohematol, Gondar, Ethiopia.
C3 University of Gondar
RP Kelem, A (corresponding author), Debre Berhan Univ, Dept Med Lab Sci, Asrat Woldeyes Hlth Sci Campus, Debre Berhan, Ethiopia.
EM amanuelkelem@gmail.com
RI Adane, Tiruneh/AAV-2999-2021
OI Adane, Tiruneh/0000-0001-6597-5755; Kelem, Amanuel/0000-0002-4021-0171
FU University of Gondar
FX The study was funded by the University of Gondar. The funders had no
   role in study design, data collection and analysis, decision to publish,
   or preparation of the manuscript.
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NR 89
TC 4
Z9 4
U1 0
U2 1
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAY 25
PY 2023
VL 18
IS 5
AR e0286163
DI 10.1371/journal.pone.0286163
PG 22
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA H4ZZ2
UT WOS:000996075100043
PM 37228109
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Peiseler, M
   Schwabe, RF
   Hampe, J
   Kubes, P
   Heikenwaelder, M
   Tacke, F
AF Peiseler, Moritz
   Schwabe, Robert F.
   Hampe, Jochen
   Kubes, Paul
   Heikenwaelder, Mathias
   Tacke, Frank
TI Immune mechanisms linking metabolic injury to inflammation and fibrosis
   in fatty liver disease - novel insights into cellular communication
   circuits
SO JOURNAL OF HEPATOLOGY
LA English
DT Review
DE NAFLD; NASH; Single-cell sequencing; spatial transcriptomics; Kupffer
   cells; immune-mediated liver disease; macrophages; cancer immunotherapy;
   HCC; exhausted T cells; PPAR agonists; FXR agonists; scRNA-seq; MAFLD
ID NEUTROPHIL EXTRACELLULAR TRAPS; PROMOTE INSULIN-RESISTANCE; CAUSES
   NONALCOHOLIC STEATOHEPATITIS; HEPATIC STELLATE CELLS; T-CELL; KUPFFER
   CELLS; TISSUE HOMEOSTASIS; MOUSE MODEL; MACROPHAGES; OBESITY
AB Non-alcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease and is emerging as the leading cause of cirrhosis, liver transplantation and hepatocellular carcinoma (HCC). NAFLD is a metabolic disease that is considered the hepatic manifestation of the metabolic syndrome; however, during the evolution of NAFLD from steatosis to non-alcoholic steatohepatitis (NASH), to more advanced stages of NASH with liver fibrosis, the immune system plays an integral role. Triggers for inflammation are rooted in hepatic (lipid overload, lipotoxicity, oxidative stress) and extrahepatic (gut-liver axis, adipose tissue, skeletal muscle) systems, resulting in unique immune-mediated pathomechanisms in NAFLD. In recent years, the implementation of single-cell RNA-sequencing and high dimensional multiomics (proteogenomics, lipidomics) and spatial transcriptomics have tremendously advanced our understanding of the complex heterogeneity of various liver immune cell subsets in health and disease. In NAFLD, several emerging inflammatory mechanisms have been uncovered, including profound macrophage heterogeneity, auto-aggressive T cells, the role of unconventional T cells and platelet-immune cell interactions, potentially yielding novel therapeutics. In this review, we will highlight the recent discoveries related to inflammation in NAFLD, discuss the role of immune cell subsets during the different stages of the disease (including disease regression) and integrate the multiple systems driving inflammation. We propose a refined concept by which the immune system contributes to all stages of NAFLD and discuss open scientific questions arising from this paradigm shift that need to be unravelled in the coming years. Finally, we discuss novel therapeutic approaches to target the multiple triggers of inflammation, including combination therapy via nuclear receptors (FXR agonists, PPAR agonists). (c) 2022 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
C1 [Peiseler, Moritz; Schwabe, Robert F.; Tacke, Frank] Charite Univ Med Berlin, Dept Hepatol & Gastroenterol, Campus Virchow Klinikum & Campus Charite Mitte, Berlin, Germany.
   [Peiseler, Moritz] Berlin Inst Hlth BIH, Berlin, Germany.
   [Schwabe, Robert F.] Columbia Univ, Berlin Med, New York, NY USA.
   [Hampe, Jochen] Tech Univ Dresden, Univ Med Ctr Dresden, Dept Med 1, Dresden, Germany.
   [Kubes, Paul] Univ Calgary, Snyder Inst Chron Dis, Calgary, AB, Canada.
   [Heikenwaelder, Mathias] German Canc Res Ctr Heidelberg DKZF, Div Chron flammat & Canc, Heidelberg, Germany.
   [Tacke, Frank] Charite Univ Med Berlin, Augustenburger Pl 1, D-13353 Berlin, Germany.
C3 Berlin Institute of Health; Free University of Berlin; Humboldt
   University of Berlin; Charite Universitatsmedizin Berlin; Berlin
   Institute of Health; Columbia University; Technische Universitat
   Dresden; University of Calgary; Berlin Institute of Health; Free
   University of Berlin; Humboldt University of Berlin; Charite
   Universitatsmedizin Berlin
RP Tacke, F (corresponding author), Charite Univ Med Berlin, Augustenburger Pl 1, D-13353 Berlin, Germany.
EM frank.tacke@charite.de
RI Tacke, Frank/ABF-2212-2020; Schwabe, Robert/AAY-6506-2021; Hampe,
   Jochen/A-2555-2010
OI Tacke, Frank/0000-0001-6206-0226; Peiseler, Moritz/0000-0001-6195-3866;
   Hampe, Jochen/0000-0002-2421-6127
FU BIH clinician scientist program; German Research Foundation (DFG)
   [SFB/TRR 296, CRC1382, 403224013]; German Ministry of Education and
   Research (BMBF DEEP-HCC consortium); NSERC [RGPIN/07191-2019]; Heart &
   Stroke Foundation of Canada; CIHR; Canada Research Chairs Program;
   European Reseach Council, EU (ERC) [272983813, SFB/TR 209, 314905040,
   360372040, SFBTR179, SFBTR1335]; Wilhelm Sander-Stiftung; Research
   Foundation Flanders (FWO) [30826052]; Rainer Hoenig Stiftung; Deutsche
   Krebshilfe [70113166, 70113167]; Horizon 2020 grant; German-Israeli
   Cooperation in Cancer Research (DKFZ-MOST); Zukunftsthema"Immunology and
   Inflammation"; Helmholtz-Gemeinschaft; NIH [CA190844, CA228483]; German
   Ministry of Research and Education (BmBF) through the Liver Systems
   Medicine (LiSyM) network grant; ERACOSysMed (Dynaflow) grant;  [ZT-0027]
FX <STRONG>Acknowledgements</STRONG>MP is supported by the BIH clinician
   scientist program. FT is supported by the German Research Foundation
   (DFG SFB/TRR 296 and CRC1382, Project-ID 403224013) and the German
   Ministry of Education and Research (BMBF DEEP-HCC con-sortium). PK is
   supported by the NSERC Discover grant (RGPIN/07191-2019), the Heart &
   Stroke Foundation of Canada, CIHR and Canada Research Chairs Program. MH
   is supported by an European Reseach Council, EU (ERC) Consolidator
   grant(HepatoMetaboPath), SFBTR179 Project-ID272983813, SFB/TR 209
   Project-ID 314905040,SFBTR1335 Project-ID 360372040, the
   WilhelmSander-Stiftung, the Rainer Hoenig Stiftung, a Ho-rizon 2020
   grant (Hepcar), Research FoundationFlanders (FWO) under grant 30826052
   (EOSConvention MODEL-IDI), Deutsche Krebshilfe pro-jects 70113166 and
   70113167, German-IsraeliCooperation in Cancer Research (DKFZ-MOST), and
   the Helmholtz-Gemeinschaft, Zukunftsthema"Immunology and
   Inflammation"(ZT-0027). RFS issupported by NIH grants CA190844 and
   CA228483.JH is supported by the German Ministry of Research and
   Education (BmBF) through the LiverSystems Medicine (LiSyM) network grant
   and ERACOSysMed (Dynaflow) grant.
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NR 289
TC 295
Z9 310
U1 60
U2 381
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0168-8278
EI 1600-0641
J9 J HEPATOL
JI J. Hepatol.
PD OCT
PY 2022
VL 77
IS 4
BP 1136
EP 1160
DI 10.1016/j.jhep.2022.06.012
EA SEP 2022
PG 25
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 4Z5RP
UT WOS:000862265900005
PM 35750137
OA Bronze
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Rudnicka, E
   Suchta, K
   Grymowicz, M
   Calik-Ksepka, A
   Smolarczyk, K
   Duszewska, AM
   Smolarczyk, R
   Meczekalski, B
AF Rudnicka, Ewa
   Suchta, Katarzyna
   Grymowicz, Monika
   Calik-Ksepka, Anna
   Smolarczyk, Katarzyna
   Duszewska, Anna M.
   Smolarczyk, Roman
   Meczekalski, Blazej
TI Chronic Low Grade Inflammation in Pathogenesis of PCOS
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE polycystic ovary syndrome; insulin resistance; chronic inflammation;
   interleukins; CRP
ID OBESITY
AB Polycystic ovary syndrome (PCOS) is a one of the most common endocrine disorders, with a prevalence rate of 5-10% in reproductive aged women. It's characterized by (1) chronic anovulation, (2) biochemical and/or clinical hyperandrogenism, and (3) polycystic ovarian morphology. PCOS has significant clinical implications and can lead to health problems related to the accumulation of adipose tissue, such as obesity, insulin resistance, metabolic syndrome, and type 2 diabetes. There is also evidence that PCOS patients are at higher risk of cardiovascular diseases, atherosclerosis, and high blood pressure. Several studies have reported the association between polycystic ovary syndrome (PCOS) and low-grade chronic inflammation. According to known data, inflammatory markers or their gene markers are higher in PCOS patients. Correlations have been found between increased levels of C-reactive protein (CRP), interleukin 18 (IL-18), tumor necrosis factor (TNF-alpha), interleukin 6 (IL-6), white blood cell count (WBC), monocyte chemoattractant protein-1 (MCP-1) and macrophage inflammatory protein-1 alpha (MIP-1 alpha) in the PCOS women compared with age- and BMI-matched controls. Women with PCOS present also elevated levels of AGEs and increased RAGE (receptor for advanced glycation end products) expression. This chronic inflammatory state is aggravating by obesity and hyperinsulinemia. There are studies describing mutual impact of hyperinsulinemia and obesity, hyperandrogenism, and inflammatory state. Endothelial cell dysfunction may be also triggered by inflammatory cytokines. Many factors involved in oxidative stress, inflammation, and thrombosis were proposed as cardiovascular risk markers showing the endothelial cell damage in PCOS. Those markers include asymmetric dimethylarginine (ADMA), C-reactive protein (CRP), homocysteine, plasminogen activator inhibitor-I (PAI-I), PAI-I activity, vascular endothelial growth factor (VEGF) etc. It was also proposed that the uterine hyperinflammatory state in polycystic ovary syndrome may be responsible for significant pregnancy complications ranging from miscarriage to placental insufficiency. In this review, we discuss the most importance evidence concerning the role of the process of chronic inflammation in pathogenesis of PCOS.
C1 [Rudnicka, Ewa; Suchta, Katarzyna; Grymowicz, Monika; Calik-Ksepka, Anna; Smolarczyk, Roman] Med Univ Warsaw, Dept Gynaecol Endocrinol, PL-00315 Warsaw, Poland.
   [Smolarczyk, Katarzyna] Med Univ Warsaw, Dept Dermatol & Venereol, PL-00315 Warsaw, Poland.
   [Duszewska, Anna M.] Warsaw Univ Life Sci, Fac Vet Med, Dept Morphol Sci, PL-02787 Warsaw, Poland.
   [Meczekalski, Blazej] Poznan Univ Med Sci, Dept Gynaecol Endocrinol, PL-60535 Poznan, Poland.
C3 Medical University of Warsaw; Medical University of Warsaw; Warsaw
   University of Life Sciences; Poznan University of Medical Sciences
RP Rudnicka, E (corresponding author), Med Univ Warsaw, Dept Gynaecol Endocrinol, PL-00315 Warsaw, Poland.
EM ewa.rudnicka@poczta.onet.pl; suchta.katarzyna@gmail.com;
   monika.grymowicz@wp.pl; calikowna@wp.pl; rsmolarczyk@poczta.onet.pl;
   anna_duszewska@sggw.edu.pl; ksmolarczyk@gmail.com;
   blazejmeczekalski@ump.edu.pl
RI Suchta, Katarzyna/KBA-7024-2024; Rudnicka, Ewa/U-4988-2018
OI Suchta, Katarzyna/0000-0003-1715-1262; Rudnicka,
   Ewa/0000-0002-3936-5598; Duszewska, Anna/0000-0003-3336-9667;
   Smolarczyk, Roman/0000-0002-4420-5433
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NR 97
TC 327
Z9 358
U1 25
U2 126
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD APR
PY 2021
VL 22
IS 7
AR 3789
DI 10.3390/ijms22073789
PG 12
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA RK9TO
UT WOS:000638629300001
PM 33917519
OA gold, Green Published
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Barre, DE
   Mizier-Barre, KA
AF Barre, Douglas Edward
   Mizier-Barre, Kazimiera Amella
TI Lignans' Potential in Pre and Post-onset Type 2 Diabetes Management
SO CURRENT DIABETES REVIEWS
LA English
DT Review
DE Lignans; type 2 diabetes; polypharmacy; low density lipoprotein; plasma;
   glucose
ID C-REACTIVE PROTEIN; LOW-DENSITY-LIPOPROTEIN; CORONARY-HEART-DISEASE;
   STAGE RENAL-DISEASE; SECOISOLARICIRESINOL DIGLUCOSIDE; OXIDATIVE STRESS;
   METABOLIC SYNDROME; ENDOTHELIAL DYSFUNCTION; INSULIN-RESISTANCE;
   DIETARY-INTAKE
AB Introduction: Type 2 Diabetes (T2D) cases continue to rise dramatically despite efforts to get people to exercise and eat with a view to health and combatting the cluster of 7 issues (central obesity (elevated waist circumference), hyperglycaemia, hypertension, dyslipidemia, pro-thrombotic state, increased oxidation (including Low-density Lipoprotein (LDL)) and the pro-inflammatory state associated with pre- and post-onset T2D.
   Background: There are numerous medications available to deal with these seven major issues. However, each medication currently available manages a maximum of two cluster members at a time. Consequently, polypharmacy is frequently required to manage the cluster of seven. Polypharmacy brings with it high financial costs for numerous medications, the risk of poor compliance (particularly so in older patients), side effects and drug interactions. Thus, there is a search for new agents that reduce the high costs and risks of polypharmacy while at the same time combatting three or more of the cluster of seven. There is very limited evidence to suggest that one or more lignans may efficaciously and safely, in the short and long term, manage at least three of the cluster of seven, pre- and post-T2D onset, thus reducing polypharmacy. However, multi-centre, large clinical trials are required before any definitive conclusions about these lignans can be reached regarding their safe and efficacious polypharmacy reduction potential, both long and short-term, in pre and post-onset T2D management.
   Conclusion: It is concluded that some lignans appear to have the potential to manage at least three members of the cluster of seven in pre- or post-T2D onset and hence reduce polypharmacy but much more investigation is required to confirm if such is the case. At the moment, there is not enough evidence that any of the lignans will, in the long or short term, safely and efficaciously manage the cluster of seven via polypharmacy reduction.
C1 [Barre, Douglas Edward; Mizier-Barre, Kazimiera Amella] Cape Breton Univ, Dept Hlth Sci, Sydney, NS, Canada.
C3 Cape Breton University
RP Barre, DE (corresponding author), Cape Breton Univ, Dept Hlth Sci, Sydney, NS, Canada.
EM ed_barre@cbu.ca
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NR 114
TC 13
Z9 13
U1 1
U2 6
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1573-3998
EI 1875-6417
J9 CURR DIABETES REV
JI Curr. Diabetes Reviews
PY 2020
VL 16
IS 1
BP 2
EP 11
DI 10.2174/1573399814666180914094520
PG 10
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA KE3QP
UT WOS:000508474100002
PM 30215336
DA 2025-06-11
ER

PT J
AU Suraphad, P
   Suklaew, PO
   Ngamukote, S
   Adisakwattana, S
   Mäkynen, K
AF Suraphad, Passakorn
   Suklaew, Phim On
   Ngamukote, Sathaporn
   Adisakwattana, Sirichai
   Makynen, Kittana
TI The Effect of Isomaltulose Together with Green Tea on Glycemic Response
   and Antioxidant Capacity: A Single-Blind, Crossover Study in Healthy
   Subjects
SO NUTRIENTS
LA English
DT Article
DE isomaltulose; green tea; sucrose; glycemic response; antioxidant
   capacity
ID POSTPRANDIAL PLASMA-GLUCOSE; TYPE-2 DIABETES-MELLITUS;
   CORONARY-ARTERY-DISEASE; BEVERAGE CONSUMPTION; OVERWEIGHT SUBJECTS;
   METABOLIC SYNDROME; OXIDATIVE STRESS; BLOOD-GLUCOSE; BODY-WEIGHT; HUMANS
AB Isomaltulose, a naturally-occurring isomer of sucrose, is commonly used as an alternative sweetener in foods and beverages. The goal of this study was to determine the effect of isomaltulose together with green tea on postprandial plasma glucose and insulin concentration, as well as antioxidant capacity in healthy subjects. In a randomized, single-blind, crossover study, 15 healthy subjects (eight women and seven men; ages 23.5 +/- 0.7 years; with body mass index of 22.6 +/- 0.4 kg/m(2)) consumed five beverages: (1) 50 g sucrose in 400 mL water; (2) 50 g isomaltulose in 400 mL of water; (3) 400 mL of green tea; (4) 50 g sucrose in 400 mL of green tea; and (5) 50 g isomaltulose in 400 mL of green tea. Incremental area under postprandial plasma glucose, insulin, ferric reducing ability of plasma (FRAP) and malondialdehyde (MDA) concentration were determined during 120 min of administration. Following the consumption of isomaltulose, the incremental 2-h area under the curve (AUC(0-2 h)) indicated a higher reduction of postprandial glucose (43.4%) and insulin concentration (42.0%) than the consumption of sucrose. The addition of green tea to isomaltulose produced a greater suppression of postprandial plasma glucose (20.9%) and insulin concentration (37.7%). In accordance with antioxidant capacity, consumption of sucrose (40.0%) and isomaltulose (28.7%) caused the reduction of green tea-induced postprandial increases in FRAP. A reduction in postprandial MDA after drinking green tea was attenuated when consumed with sucrose (34.7%) and isomaltulose (17.2%). In conclusion, green tea could enhance the reduction of postprandial glucose and insulin concentration when consumed with isomaltulose. In comparison with sucrose, isomaltulose demonstrated less alteration of plasma antioxidant capacity after being consumed with green tea.
C1 [Suraphad, Passakorn; Suklaew, Phim On; Ngamukote, Sathaporn; Adisakwattana, Sirichai; Makynen, Kittana] Chulalongkorn Univ, Fac Allied Hlth Sci, Dept Nutr & Dietet, Bangkok 10330, Thailand.
C3 Chulalongkorn University
RP Mäkynen, K (corresponding author), Chulalongkorn Univ, Fac Allied Hlth Sci, Dept Nutr & Dietet, Bangkok 10330, Thailand.
EM tostimulus@hotmail.com; red_flower_bow@hotmail.com; amppam10@gmail.com;
   Sirichai.a@chula.ac.th; Kittana.m@chula.ac.th
OI Makynen, Kittana/0000-0002-3856-5600; Adisakwattana,
   Sirichai/0000-0002-7938-6561
FU 90th Anniversary of Chulalongkorn University Fund (Ratchadaphiseksomphot
   Endowment Fund); Grant for International Research Integration: Chula
   Research Scholar, Ratchadaphiseksomphot Endowment Fund
FX We acknowledge the financial support of the 90th Anniversary of
   Chulalongkorn University Fund (Ratchadaphiseksomphot Endowment Fund).
   This research was supported by the Grant for International Research
   Integration: Chula Research Scholar, Ratchadaphiseksomphot Endowment
   Fund.
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NR 54
TC 14
Z9 14
U1 3
U2 20
PU MDPI AG
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 2072-6643
J9 NUTRIENTS
JI Nutrients
PD MAY
PY 2017
VL 9
IS 5
AR 464
DI 10.3390/nu9050464
PG 13
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA EV8SU
UT WOS:000402054500042
PM 28481230
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Kroy, DC
   Schumacher, F
   Ramadori, P
   Hatting, M
   Bergheim, I
   Gassler, N
   Boekschoten, MV
   Müller, M
   Streetz, KL
   Trautwein, C
AF Kroy, Daniela C.
   Schumacher, Fabienne
   Ramadori, Pierluigi
   Hatting, Maximilian
   Bergheim, Ina
   Gassler, Nikolaus
   Boekschoten, Mark V.
   Mueller, Michael
   Streetz, Konrad L.
   Trautwein, Christian
TI Hepatocyte specific deletion of c-Met leads to the
   development of severe non-alcoholic steatohepatitis in mice
SO JOURNAL OF HEPATOLOGY
LA English
DT Article
DE HGF; c-Met; NASH
ID FATTY LIVER-DISEASE; GROWTH-FACTOR; HEPATOCELLULAR-CARCINOMA;
   NATURAL-HISTORY; RISK-FACTORS; RECEPTOR; FAS; PROGRESSION; STEATOSIS;
   HOMEOSTASIS
AB Background & Aims: Non-alcoholic-fatty-liver disease (NAFLD) is part of the metabolic syndrome. The spectrum of NAFLD includes NASH (non-alcoholic steatohepatitis), which is characterised by progressive inflammation associated with oxidative stress and apoptosis, finally triggering liver cirrhosis and hepatocellular carcinoma. HGF (hepatocyte growth factor)/ mesenchymal-epithelial transition factor (c-Met) receptor signalling is known to activate distinct intracellular pathways mediating among others anti-apoptotic properties to hepatocytes. Therefore, the aim was to characterise the role of c-Met during NASH development.
   Methods: Hepatocyte specific c-Met knockout mice (c-Met Delta(hepa)) using the cre-loxP system and wild type controls (c-Met(loxP/loxP)) were fed a methionine-choline deficient (MCD) diet.
   Results: MCD feeding triggered massive steatosis, decreased survival and higher transaminases in c-Met Delta(hepa) livers compared to c-Met(loxP/loxP). Gene array analysis demonstrated that genes involved in fatty acid metabolism were strongly upregulated in c-Met Delta(hepa) livers correlating with higher amounts of hepatic free fatty acids. Consequently, c-Met Delta(hepa) mice showed significantly more TUNEL positive cells and more superoxide anion production than c-Met(loxPloxP) animals. Additionally, c-Met Delta(hepa) livers showed significantly larger fractions of infiltrating neutrophils, macrophages, and cytotoxic T cells. These changes correlated with an enhanced progression of liver fibrosis as evidenced by higher collagen deposition in c-Metz Delta(hepa) livers. As increased apoptosis was a prominent feature in c-Met Delta(hepa) livers, we generated c-Met Delta(hepa) double knockout mice. In these animals compared to c-Met Delta(hepa) animals the increase in apoptosis could be reverted.
   Conclusions: c-Met deletion in hepatocytes triggers NASH progression. A prominent mechanism is higher fatty acid accumulation and increased apoptosis, which in part can be reverted by blocking caspase 8. (C) 2014 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
C1 [Kroy, Daniela C.; Schumacher, Fabienne; Ramadori, Pierluigi; Hatting, Maximilian; Streetz, Konrad L.; Trautwein, Christian] RWTH Univ Hosp, Dept Med 3, D-52074 Aachen, Germany.
   [Gassler, Nikolaus] RWTH Univ Hosp, Inst Pathol, D-52074 Aachen, Germany.
   [Boekschoten, Mark V.; Mueller, Michael] Wageningen Univ, Nutr Metab & Genom Grp, Div Human Nutr, NL-6700 AP Wageningen, Netherlands.
   [Bergheim, Ina] Univ Jena, Inst Nutr, D-07743 Jena, Germany.
C3 RWTH Aachen University; RWTH Aachen University Hospital; RWTH Aachen
   University; RWTH Aachen University Hospital; Wageningen University &
   Research; Friedrich Schiller University of Jena
RP Kroy, DC (corresponding author), RWTH Univ Hosp, Dept Med 3, Pauwelsstr 30, D-52074 Aachen, Germany.
EM dkroy@ukaachen.de
RI Muller, Michael/M-5724-2019; Boekschoten, Mark/AAS-4597-2021; Ramadori,
   Pierluigi/AAZ-7533-2021; Boekschoten, Mark/A-2458-2011; Muller,
   Michael/B-5795-2008
OI Boekschoten, Mark/0000-0002-2139-0795; Muller,
   Michael/0000-0002-5930-9905
FU Bundesministerium fur Bildung und Forschung [01KU1214B];  [SFB/TRR57]
FX This work was supported by the SFB/TRR57 and the Bundesministerium fur
   Bildung und Forschung (ObiHep grant #01KU1214B).
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NR 35
TC 56
Z9 59
U1 0
U2 19
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0168-8278
EI 1600-0641
J9 J HEPATOL
JI J. Hepatol.
PD OCT
PY 2014
VL 61
IS 4
BP 883
EP 890
DI 10.1016/j.jhep.2014.05.019
PG 8
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA AP7IY
UT WOS:000342252200025
PM 24845607
DA 2025-06-11
ER

PT J
AU Wang, SF
   Shu, Z
   Tao, QS
   Yu, CQ
   Zhan, SY
   Li, LM
AF Wang, Shengfeng
   Shu, Zheng
   Tao, Qiushan
   Yu, Canqing
   Zhan, Siyan
   Li, Liming
TI Uric acid and incident chronic kidney disease in a large health check-up
   population in Taiwan
SO NEPHROLOGY
LA English
DT Article
DE chronic kidney disease; clinical epidemiology; glomerular filtration
   rate; uric acid
ID STAGE RENAL-DISEASE; ALL-CAUSE MORTALITY; SERUM CREATININE;
   CARDIOVASCULAR-DISEASE; ESSENTIAL-HYPERTENSION; RISK-FACTOR;
   CLASSIFICATION; ASSOCIATION; PROGRESSION; PREVALENCE
AB Aim: Uric acid (UA) is strongly associated with the confirmed chronic kidney disease (CKD) risk factors, such as hypertension, diabetes and metabolic syndrome (MS); however, whether higher UA is independently associated with CKD is still debatable. Other studies found that low UA level may reflect inadequate protection against oxidant-mediated stress; it is also unknown whether hypouricemia may have a harmful effect on the kidney. No studies have examined whether there is a J-shaped relationship between UA and incident CKD.
   Methods: The association between UA and incident kidney disease (Glomerular filtration rate <60 mL/min per 1.73 m(2)) was examined among 94 422 Taiwanese participants, aged >= 20 years with a mean 3.5 years follow-up in a retrospective cohort. The association between UA and CKD was evaluated using Cox models with adjustment for confounders.
   Results: The adjusted hazard ratio (HR) for incident CKD was 1.03 (95% confidence interval (CI), 1.01 to 1.06) for baseline UA level (increase by 1 mg/dL). Compared with serum UA in the first quintile (2.0 to 4.5 mg/dL), the multivariate-adjusted HR for CKD of the fifth (>= 7.3 mg/dL), fourth (6.3 to 7.2 mg/dL), third (5.5 to 6.2 mg/dL), second (4.6 to 5.4 mg/dL) and hyopuricemia (<2.0 mg/dL) were 1.15 (95% CI, 1.01-1.30), 0.98 (95% CI, 0.87-1.10), 1.06 (95% CI, 0.94-1.19), 1.02 (95% CI, 0.91-1.14) and 1.65(95% CI, 0.53-5.15), respectively. The tests for the non-linear association were all not significant for both male and female. Gender-specific model revealed only the UA above 7.3 mg/dL with the increased risk of new-onset CKD in males.
   Conclusion: Hyperuricemia is a risk factor for CKD in Taiwan, future studies are still necessary to determine whether hypouricemia increases the risk of CKD.
C1 [Wang, Shengfeng; Shu, Zheng; Tao, Qiushan; Yu, Canqing; Zhan, Siyan; Li, Liming] Peking Univ, Hlth Sci Ctr, Dept Epidemiol & Biostat, Sch Publ Hlth, Beijing 100191, Peoples R China.
C3 Peking University
RP Li, LM (corresponding author), Peking Univ, Hlth Sci Ctr, Dept Epidemiol & Biostat, Sch Publ Hlth, Beijing 100191, Peoples R China.
EM lmlee@vip.163.com
RI Tao, Qiushan/HOC-8683-2023; Li, Linze/J-5187-2017
OI Tao, Qiushan/0000-0002-1852-3681; YU, Canqing/0000-0002-0019-0014
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NR 35
TC 53
Z9 55
U1 1
U2 8
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1320-5358
EI 1440-1797
J9 NEPHROLOGY
JI Nephrology
PD NOV
PY 2011
VL 16
IS 8
BP 767
EP 776
DI 10.1111/j.1440-1797.2011.01513.x
PG 10
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 853GN
UT WOS:000297414300014
PM 21854506
DA 2025-06-11
ER

PT J
AU Tatsumi, K
   Sasaki, H
   Fujita, A
   Doi, A
   Kanaya, Y
   Furuta, H
   Nishi, M
   Tsuno, T
   Taniguchi, H
   Nanjo, K
AF Tatsumi, Kunihiro
   Sasaki, Hideyuki
   Fujita, Atsuyo
   Doi, Asako
   Kanaya, Yumi
   Furuta, Hiroto
   Nishi, Masahiro
   Tsuno, Takuo
   Taniguchi, Hisaji
   Nanjo, Kishio
TI Effect of anti-oxidants, Ricetrienol and α-tocopherol, on adipocytokine
   abnormalities and fatty liver in Otsuka Long-Evans Tokushima Fatty
   diabetic rats
SO JOURNAL OF DIABETES INVESTIGATION
LA English
DT Article
DE Adipocytokine; Anti-oxidant; Fatty liver
ID ENDOTHELIAL ADHESION MOLECULES; CORONARY-HEART-DISEASE; NONALCOHOLIC
   STEATOHEPATITIS; METABOLIC SYNDROME; OXIDATIVE STRESS; VITAMIN-E;
   ADIPONECTIN; MORTALITY; MICE; TELMISARTAN
AB Introduction:
   We investigated the effect of Ricetrienol, which is an anti-oxidant extracted from rice bran, and alpha-tocopherol on the adipocytokine abnormalities and fatty liver in Otsuka Long-Evans Tokushima Fatty (OLETF) rats.
   Materials and Methods:
   A total of 18 OLETF rats were bred using a 30% sucrose solution (the diabetic group; DM), whereas another 18 OLETF rats were bred using ordinary water (the non-diabetic obese group; OB) as drinking water, respectively. After the sucrose-fed rats developed diabetes, all of the rats from the diabetic and obese groups were randomly divided into three groups. Then each group was fed either standard chow (DM-S, OB-S group), 0.05% Ricetrienol-containing chow (DM-R, OB-R group) or 0.05%alpha-tocopherol-containing chow (DM-A, OB-A group), respectively. After 12 weeks of feeding, all the rats were killed. Plasma insulin, adiponectin, resistin and leptin were assayed by enzyme immunoassay. Histopathological findings of liver tissue were scored according to Brunt and Kleiner's method, and triglyceride contents of the liver tissue were investigated.
   Results:
   Plasma adiponectin was significantly reduced in DM-S compared with OB-S, but it had significantly increased in DM-R and DM-A as opposed to DM-S. Plasma resistin showed a significant increase in DM-S compared with OB-S, but it was significantly reduced in DM-A than in DM-S. Though the triglyceride contents of liver tissue significantly increased in DM-S as opposed to OB-S, they were significantly reduced in DM-R compared with DM-S. Histopathological scores were significantly higher in DM-S than OB-S.
   Conclusions:
   The present study shows that Ricetrienol might prevent adipocytokine abnormalities and fatty liver in OLETF diabetic rats. (J Diabetes Invest, doi: 10.1111/j.2040-1124.2010.00090.x, 2011).
C1 [Tatsumi, Kunihiro; Sasaki, Hideyuki; Fujita, Atsuyo; Doi, Asako; Furuta, Hiroto; Nishi, Masahiro; Nanjo, Kishio] Wakayama Med Univ, Dept Med 1, Wakayama, Japan.
   [Kanaya, Yumi; Tsuno, Takuo] Tsuno Food Ind Co Ltd, Dept Res & Dev, Wakayama, Japan.
   [Taniguchi, Hisaji] Wakayama Prefectural Ind Tech Ctr, Div Chem Technol, Wakayama, Japan.
C3 Wakayama Medical University
RP Sasaki, H (corresponding author), Wakayama Med Univ, Dept Med 1, Wakayama, Japan.
EM sasaki-h@wakayama-med.ac.jp
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NR 26
TC 3
Z9 3
U1 0
U2 4
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 2040-1116
J9 J DIABETES INVEST
JI J. Diabetes Investig.
PD JUN
PY 2011
VL 2
IS 3
BP 186
EP 192
DI 10.1111/j.2040-1124.2010.00090.x
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 773MA
UT WOS:000291310200007
PM 24843482
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Erdei, N
   Toth, A
   Pasztor, ET
   Papp, Z
   Edes, I
   Koller, A
   Bagi, Z
AF Erdei, Nora
   Toth, Attila
   Pasztor, Eniko T.
   Papp, Zoltan
   Edes, Istvan
   Koller, Akos
   Bagi, Zsolt
TI High-fat diet-induced reduction in nitric oxide-dependent arteriolar
   dilation in rats: role of xanthine oxidase-derived superoxide anion
SO AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
LA English
DT Article
DE metabolic syndrome; high-fat diet; microvessel; endothelium; nitric
   oxide; superoxide; xanthine oxidase; allopurinol
ID ENDOTHELIAL DYSFUNCTION; CORONARY ARTERIOLES; CARDIOVASCULAR-DISEASE;
   HYPERPOLARIZING FACTOR; RESISTANCE VESSELS; OXIDATIVE STRESS;
   BLOOD-PRESSURE; SYNTHASE; NO; HYPERTENSION
AB Obesity frequently leads to the development of hypertension. We hypothesized that high-fat diet (HFD)-induced obesity impairs the endothelium-dependent dilation of arterioles. Male Wistar rats were fed with normal (control) or HFD (60% of saturated fat, for 10 wk). In rats with HFD, body weight, mean arterial blood pressure, and serum insulin, cholesterol, and glucose were elevated. In isolated gracilis muscle arterioles (diameter: similar to 160 mu m) of HFD, rat dilations to ACh (at 1 mu M, maximum: 83 +/- 3%) and histamine (at 10 mu M, maximum: 16 +/- 4%) were significantly (P < 0.05) decreased compared with those of control responses (maximum: 90 +/- 2 and 46 +/- 4%, respectively). Dilations to the NO donor sodium nitroprusside were similar in the two groups. Inhibition of NO synthesis by N-omega-nitro-L-arginine methyl ester reduced ACh-and histamine-induced dilations in control arterioles but had no effect on microvessels of HFD rats. The superoxide dismutase mimetic Tiron or xanthine oxidase inhibitor allopurinol enhanced ACh (maximum: 90 +/- 2 and 93 +/- 2%, respectively) and histamine (maximum: 30 +/- 7 and 37 +/- 8%, respectively)-induced dilations in HFD arterioles, whereas the NAD(P)H oxidase inhibitor apocynin had no significant effect. Correspondingly, in carotid arteries of HFD rats, an enhanced superoxide production was shown by lucigenin- enhanced chemiluminescence, in association with an increased xanthine oxidase, but not NAD(P)H oxidase activity. In addition, a marked xanthine oxidase immunostaining was detected in the endothelial layer of the gracilis arterioles of HFD, but not in control rats. These findings suggest that, in obese rats, NO mediation of endothelium-dependent dilation of skeletal muscle arterioles is reduced because of an enhanced xanthine oxidase-derived superoxide production. These alterations demonstrate substantial dysregulation of arteriolar tone by the endothelium in HFD-induced obesity, which may contribute to disturbed tissue blood flow and development of increased peripheral resistance.
C1 Univ Debrecen, Inst Cardiol, Div Clin Physiol, H-4004 Debrecen, Hungary.
   Semmelweis Univ, Dept Pathophysiol, Budapest, Hungary.
   New York Med Coll, Dept Physiol, Valhalla, NY 10595 USA.
C3 University of Debrecen; Semmelweis University; New York Medical College
RP Bagi, Z (corresponding author), Univ Debrecen, Inst Cardiol, Div Clin Physiol, POB 1, H-4004 Debrecen, Hungary.
EM bagizs@jaguar.unideb.hu
RI Papp, Zoltán/HDO-3347-2022; Édes, István/B-8795-2011; Ákos,
   Koller/Q-4672-2019; Toth, Attila/F-4859-2010
OI Toth, Attila/0000-0001-6503-3653; Bagi, Zsolt/0000-0001-8755-2980
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NR 44
TC 91
Z9 106
U1 0
U2 7
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0363-6135
EI 1522-1539
J9 AM J PHYSIOL-HEART C
JI Am. J. Physiol.-Heart Circul. Physiol.
PD NOV
PY 2006
VL 291
IS 5
BP H2107
EP H2115
DI 10.1152/ajpheart.00389.2006
PG 9
WC Cardiac & Cardiovascular Systems; Physiology; Peripheral Vascular
   Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Physiology
GA 092NB
UT WOS:000241102700014
PM 16798827
DA 2025-06-11
ER

PT S
AU Seres, I
   Bajnok, L
   Harangi, M
   Sztanek, F
   Koncsos, P
   Paragh, G
AF Seres, Ildiko
   Bajnok, Laszlo
   Harangi, Mariann
   Sztanek, Ferenc
   Koncsos, Peter
   Paragh, Gyoergy
BE Reddy, ST
TI Alteration of PON1 Activity in Adult and Childhood Obesity and Its
   Relation to Adipokine Levels
SO PARAOXONASES IN INFLAMMATION, INFECTION, AND TOXICOLOGY
SE Advances in Experimental Medicine and Biology
LA English
DT Article; Proceedings Paper
CT 3rd International Conference on Paraoxonases
CY SEP 07-10, 2008
CL Univ Calif Los Angeles, Los Angeles, CA
SP US Def Dept, Def Threat Reduct Agcy, Bristol-Myers Squibb
HO Univ Calif Los Angeles
DE Adipokines; Leptin; Adiponectin; Resistin; Obesity; Paraoxonase-1;
   Childhood
ID SERUM PARAOXONASE ACTIVITY; LOW-DENSITY-LIPOPROTEIN; METABOLIC SYNDROME;
   OXIDATIVE STRESS; CARDIOVASCULAR-DISEASE; OXIDIZED LDL; LEPTIN;
   ADIPONECTIN; HYPOADIPONECTINEMIA; CHOLESTEROL
AB Obesity as a pathogenic disorder is a predisposing factor for cardiovascular diseases and shows an increasing incidence in the industrialized countries. Adipokines such as leptin, adiponectin and resistin have a great impact on the development of atherosclerosis in obesity. Elevated levels of leptin have been found to be atherogenic whereas decreased levels of adiponectin have been proved to be anti-atherogenic in recent studies. The exact role of resistin in the process of atherosclerosis has so far remained uncertain and controversial. In our recent work, we studied the alteration in human paraoxonase-1 (PON1) activity and adipokine levels; furthermore, we also aimed at identifying the potential correlation between these parameters in this metabolic disorder. We investigated the above-mentioned parameters both in adults and in children, with regard to the emerging role of childhood obesity and to get a clearer view of these factors during a whole lifetime. Investigating the adult population with a broad range of body mass index (BMI) we found significantly increased leptin and significantly decreased adiponectin and resistin levels and PON1 activity in the obese group compared to the lean controls. Adiponectin and resistin levels showed significantly positive correlation, while leptin and BMI showed significantly negative correlation with PON1 activity.
   Our findings were similar in childhood obesity: leptin showed significantly negative correlation, while adiponectin showed significantly positive correlation with PON1 activity. We found gender differences in the univariate correlations of leptin and adiponectin levels with PON1 activity in the adult population. In multiple regression analysis, adiponectin proved to be an independent factor of PON1 activity both in childhood and adult obesity, furthermore thiobarbituric acid-reactive substances (TBARS) also proved to be an independent predictor of the enzyme in adults, reflecting the important role of oxidative stress in obesity. Investigating PON 192 Q/R polymorphism by phenotypic distribution (NB isoenzyme) in obese children, we found a significant correlation of PON1 arylesterase activity with leptin and adiponectin levels, and of body fat percentage with PON1 192 B isoenzyme.
   According to our studies, these metabolic changes in obesity predispose to the early development of atherosclerosis throughout our whole lifetime. Decreased activity of PON1 and alterations in adipokine levels in childhood obesity could contribute to an early commencement of this process, detected only later in adulthood by increased cardiovascular morbidity and mortality. Changed levels of leptin, adiponectin, resistin and PON1 activity at all ages, just like 192 Q/R polymorphism determined by phenotypic distribution, may be useful markers beside the general risk factors.
C1 [Seres, Ildiko; Harangi, Mariann; Sztanek, Ferenc; Koncsos, Peter; Paragh, Gyoergy] Univ Debrecen, Dept Internal Med, Med & Hlth Sci Ctr, Debrecen, Hungary.
   [Bajnok, Laszlo] Univ Pecs, Sch Med, Dept Med, Pecs, Hungary.
C3 University of Debrecen; University of Pecs
RP Seres, I (corresponding author), Univ Debrecen, Dept Internal Med, Med & Hlth Sci Ctr, Debrecen, Hungary.
EM seres@internal.med.unideb.hu; laszlo.bajnok@aok.pte.hu;
   mharangi@hotmail.com; sztanekf@yahoo.com; peterkoncsos@yahoo.com;
   paragh@internal.med.unideb.hu
RI Harangi, Mariann/ACY-2278-2022
OI Sztanek, Ferenc/0009-0005-6657-7579; Harangi,
   Mariann/0000-0001-9761-9595
CR Bajnok L, 2008, EXP CLIN ENDOCR DIAB, V116, P592, DOI 10.1055/s-2008-1065350
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NR 39
TC 27
Z9 30
U1 0
U2 7
PU SPRINGER-VERLAG BERLIN
PI BERLIN
PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY
SN 0065-2598
EI 2214-8019
BN 978-1-60761-349-7
J9 ADV EXP MED BIOL
JI Adv.Exp.Med.Biol.
PY 2010
VL 660
BP 129
EP 142
DI 10.1007/978-1-60761-350-3_12
PG 14
WC Medicine, Research & Experimental
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA BOB96
UT WOS:000276140000012
PM 20221876
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Mao, HY
   Lin, T
   Huang, SS
   Xie, ZY
   Chen, JL
   Shen, XK
   Ding, Y
   Xu, GZ
   Chen, ZK
AF Mao, Haiyan
   Lin, Tong
   Huang, Shanshan
   Xie, Zhenye
   Chen, Jialu
   Shen, Xingkai
   Ding, Yi
   Xu, Guangze
   Chen, Zhikui
TI Association between monocyte to high-density lipoprotein cholesterol
   ratio and telomere length: based on NHANES 1999-2002
SO BMC CARDIOVASCULAR DISORDERS
LA English
DT Article
DE Telomere length; Monocyte to high-density lipoprotein cholesterol ratio;
   Cardiovascular disease; NHANES
ID NUTRITION EXAMINATION SURVEY; NATIONAL-HEALTH; DISEASE; INFLAMMATION;
   RISK
AB Background Telomere length is closely associated with the occurrence and development of cardiovascular and other diseases. Monocyte to high-density lipoprotein cholesterol ratio (MHR) is a novel indicator of inflammation, oxidative stress, and metabolic syndrome, with some predictive ability for related disease risks in clinical practice. However, there is no research on the correlation between these two factors.
   Methods Using data from the National Health and Nutrition Examination Survey (NHANES) from 1999 to 2002, we conducted analysis and research on the correlation between MHR and telomere length using the Kruskal-Wallis H test, Spearman rank correlation analysis, and partial correlation analysis. Weighted linear regression analysis assessed the strength of the association between the two variables, while restricted cubic spline regression (RCS) explored potential nonlinear relationships between them.
   Results The results of correlation analysis showed that MHR levels were negatively correlated with telomere length (rho=-0.083, P < 0.001), and this relationship remained statistically significant after controlling for other covariates (P all < 0.001). Weighted linear regression analysis showed that after adjusting for all covariates, MHR remained negatively associated with telomere length (beta = -0.020; 95% CI: -0.039 to -0.002; P = 0.037). Subgroup analysis shows that the negative association between MHR and telomere length appeared more striking among females (beta = -0.024; 95%CI: -0.050 to 0.001; P = 0.058), the Non-Hispanic White (beta = -0.022; 95%CI: -0.045 to 0.002; P = 0.066), and other race (beta = -0.067; 95%CI: -0.134 to -0.000; P = 0.049). Using RCS explored potential nonlinear relationships between MHR and telomere length, revealing no nonlinear relationship between the two (P = 0.102).
   Conclusions This study suggests a negative correlation between MHR levels and telomere length in American adults. More comprehensive research is needed to confirm these findings in the future.
C1 [Mao, Haiyan; Lin, Tong; Huang, Shanshan; Xie, Zhenye; Chen, Jialu; Shen, Xingkai; Ding, Yi] Ningbo Med Ctr Lihuili Hosp, Dept Crit Care Med, Ningbo 315100, Peoples R China.
   [Xu, Guangze; Chen, Zhikui] Ningbo Med Ctr Lihuili Hosp, Dept Cardiovasc Med, Ningbo 315100, Peoples R China.
RP Chen, ZK (corresponding author), Ningbo Med Ctr Lihuili Hosp, Dept Cardiovasc Med, Ningbo 315100, Peoples R China.
EM czk32311@163.com
FU Medical Science and Technology Project of Zhejiang Province
FX Not applicable.
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NR 43
TC 0
Z9 0
U1 1
U2 1
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1471-2261
J9 BMC CARDIOVASC DISOR
JI BMC Cardiovasc. Disord.
PD NOV 4
PY 2024
VL 24
IS 1
AR 616
DI 10.1186/s12872-024-04301-3
PG 9
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA L0S3Y
UT WOS:001347903400002
PM 39497037
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Zhou, J
   Dai, Y
   Zuo, Z
   Liu, T
   Li, SY
AF Zhou, J.
   Dai, Y.
   Zuo, Z.
   Liu, Ting
   Li, Suyi
TI Famine Exposure during Early Life and Risk of Cancer in Adulthood: A
   Systematic Review and Meta-Analysis
SO JOURNAL OF NUTRITION HEALTH & AGING
LA English
DT Review
DE Famine exposure; early life; cancer; systematic review; meta-analysis
ID POSTTRAUMATIC-STRESS-DISORDER; 1944-1945 DUTCH FAMINE; BREAST-CANCER;
   ENERGY RESTRICTION; METABOLIC SYNDROME; PRENATAL FAMINE; CALORIC
   RESTRICTION; NETHERLANDS COHORT; ASSOCIATION; HETEROGENEITY
AB ObjectivesEmerging evidences have explored the association between famine exposure during early life and cancer risk in adulthood, but the results remain controversial and inconsistent. This study aimed to provide a comprehensive evidence on the relation of famine exposure to later cancer risk.DesignSystematic review and meta-analysis.MethodsRelevant reports published up to March, 2022 were identified by searching PubMed, Embase, Web of sciences and Medline databases. Pooled relative ratios (RRs) with 95% confidence intervals (CIs) were used to evaluate the effect famine exposure on cancer risk.ResultsTotally, 18 published articles with 6,061,147 subjects were included in this study. Compared with unexposed group, early life famine exposure dramatically increased the risk of cancer in adulthood (RR=1.13, 95% CI: 1.04-1.22). The pooled RRs were different in terms of sex, exposure severity, exposure period, famine type, study design type and cancer location. A remarkably elevated risk for cancer was discerned in women exposed to famine (RR=1.09, 95% CI: 1.00-1.18), severe exposure (RR=1.12, 95% CI: 1.02-1.22) and adolescence exposure (RR=1.76, 95% CI: 1.02-2.50), Chinese famine exposure (RR=1.55, 95% CI: 1.29-1.82) and cohort studies (RR=1.28, 95% CI: 1.13-1.42). Moreover, a significant association of early-life famine exposure with increased risk of breast (RR=1.16, 95% CI: 1.05-1.27) and stomach cancers (RR=1.89, 95% CI: 1.24-2.54) was observed.ConclusionThis meta-analysis suggests that exposure to famine during early life may increase the risk of cancer in adulthood. The above-mentioned association is pronounced in women exposed to famine, severe exposure, adolescence exposure, Chinese famine, cohort studies, breast and stomach cancers. It is essential for decision-makers to take targeted measures for improving population awareness regarding the long-term effect of early life nutritional status.
C1 [Zhou, J.; Zuo, Z.; Li, Suyi] Univ Sci & Technol China, Anhui Prov Canc Hosp, Affiliated Hosp 1, Dept Oncol, 107 Huanhu East Rd, Hefei, Anhui, Peoples R China.
   [Dai, Y.] Anhui Med Univ, Suzhou Hosp, Dept Urol, Suzhou, Anhui, Peoples R China.
   [Liu, Ting] Capital Med Univ, Sch Pharmaceut Sci, Dept Pharmaceut, Beijing 100069, Peoples R China.
C3 Chinese Academy of Sciences; University of Science & Technology of
   China, CAS; Anhui Medical University; Capital Medical University
RP Li, SY (corresponding author), Univ Sci & Technol China, Anhui Prov Canc Hosp, Affiliated Hosp 1, Dept Oncol, 107 Huanhu East Rd, Hefei, Anhui, Peoples R China.; Liu, T (corresponding author), Capital Med Univ, Sch Pharmaceut Sci, Dept Pharmaceut, Beijing 100069, Peoples R China.
EM liuting9019@163.com; njlisuyi@sina.com
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NR 63
TC 4
Z9 4
U1 0
U2 4
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1279-7707
EI 1760-4788
J9 J NUTR HEALTH AGING
JI J. Nutr. Health Aging
PD JUL
PY 2023
VL 27
IS 7
BP 550
EP 558
DI 10.1007/s12603-023-1947-4
EA JUL 2023
PG 9
WC Geriatrics & Gerontology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology; Nutrition & Dietetics
GA M8DX7
UT WOS:001023882400001
PM 37498102
OA hybrid
DA 2025-06-11
ER

PT J
AU Gulati, S
   Misra, A
   Tiwari, R
   Sharma, M
   Pandey, RM
   Upadhyay, AD
   Sati, HC
AF Gulati, Seema
   Misra, Anoop
   Tiwari, Rajneesh
   Sharma, Meenu
   Pandey, Ravindra M. M.
   Upadhyay, Ashish Datt
   Sati, Hem Chandra
TI Beneficial effects of premeal almond load on glucose profile on oral
   glucose tolerance and continuous glucose monitoring: randomized
   crossover trials in Asian Indians with prediabetes
SO EUROPEAN JOURNAL OF CLINICAL NUTRITION
LA English
DT Article
ID TYPE-2 DIABETES-MELLITUS; METABOLIC SYNDROME; POSTPRANDIAL GLYCEMIA;
   OXIDATIVE STRESS; CARDIOVASCULAR-DISEASES; RISK-FACTORS; HYPERGLYCEMIA;
   DIETARY; OBESITY; FLUCTUATIONS
AB BackgroundRapid conversion from prediabetes to diabetes and frequent postprandial hyperglycemia (PPHG) is seen in Asian Indians. These should be the target of dietary strategies.ObjectivesWe hypothesized that dietary intervention of preloading major meals with almonds in participants with prediabetes will decrease overall glycemia and PPHG.DesignThe study included two phases: (1) an oral glucose tolerance test (OGTT)-based crossover randomized control study, the effect of a single premeal almond load (20 g) given before OGTT was evaluated (n = 60, 30 each period). (2) The continuous glucose monitoring system (CGMS)-based study for 3 days including premeal almond load before three major meals was a free-living, open-labeled, crossover randomized control trial, where control and premeal almond load diets were compared for glycaemic control (n = 60, 30 in each period). The study was registered at clinicaltrials.gov (registration no. NCT04769726).ResultsIn the OGTT-based study phase, the overall AUC for blood glucose, serum insulin, C-peptide, and plasma glucagon post-75 g oral glucose load was significantly lower for treatment vs. control diet (p < 0.001). Specifically, with the former diet, PPHG was significantly lower (18.05% in AUC on OGTT, 24.8% at 1-h, 28.9% at 2-h post OGTT, and 10.07% during CGMS). The CGMS data showed that premeal almond load significantly improved 24-glucose variability; SD of mean glucose concentration and mean of daily differences. Daily glycaemic control improved significantly as per the following: mean 24-h blood glucose concentration (M), time spent above 7.8 mmol/L of blood glucose, together with the corresponding AUC values. Premeal almond load significantly decreased following: overall hyperglycemia (glucose AUC), PPHG, peak 24-h glycaemia, and minimum glucose level during night.ConclusionIncorporation of 20 g of almonds, 30 min before each major meal led to a significant decrease in PPHG (as revealed in OGTT-based study phase) and also improved insulin, C-peptide, glucagon levels, and improved glucose variability and glycemic parameters on CGMS in participants with prediabetes.
C1 [Gulati, Seema; Misra, Anoop] Diabet Fdn India, New Delhi, India.
   [Gulati, Seema; Misra, Anoop; Tiwari, Rajneesh; Sharma, Meenu] Natl Diabet Obes & Cholesterol Fdn N DOC, New Delhi, India.
   [Gulati, Seema; Misra, Anoop] Ctr Nutr & Metab Res C NET, New Delhi, India.
   [Misra, Anoop] Fortis C DOC Ctr Excellence Diabet Metab Dis & End, New Delhi, India.
   [Pandey, Ravindra M. M.; Upadhyay, Ashish Datt; Sati, Hem Chandra] All India Inst Med Sci, New Delhi, India.
C3 All India Institute of Medical Sciences (AIIMS) New Delhi
RP Misra, A (corresponding author), Diabet Fdn India, New Delhi, India.; Misra, A (corresponding author), Natl Diabet Obes & Cholesterol Fdn N DOC, New Delhi, India.; Misra, A (corresponding author), Ctr Nutr & Metab Res C NET, New Delhi, India.; Misra, A (corresponding author), Fortis C DOC Ctr Excellence Diabet Metab Dis & End, New Delhi, India.
EM anoopmisra@gmail.com
RI Upadhyay, Ashish Datt/GOJ-9023-2022
FU Almond Board of California, California, USA
FX Almond Board of California, California, USA.
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NR 47
TC 8
Z9 9
U1 0
U2 3
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0954-3007
EI 1476-5640
J9 EUR J CLIN NUTR
JI Eur. J. Clin. Nutr.
PD MAY
PY 2023
VL 77
IS 5
BP 586
EP 595
DI 10.1038/s41430-023-01263-1
EA FEB 2023
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA F8OR1
UT WOS:000924458000001
PM 36732571
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Tuomisto, K
   Palmu, J
   Long, T
   Watrous, JD
   Mercader, K
   Lagerborg, KA
   Andres, A
   Salmi, M
   Jalkanen, S
   Vasan, RS
   Inouye, M
   Havulinna, AS
   Tuomilehto, J
   Jousilahti, P
   Niiranen, TJ
   Cheng, SS
   Jain, M
   Salomaa, V
AF Tuomisto, Karolina
   Palmu, Joonatan
   Long, Tao
   Watrous, Jeramie D.
   Mercader, Kysha
   Lagerborg, Kim A.
   Andres, Allen
   Salmi, Marko
   Jalkanen, Sirpa
   Vasan, Ramachandran S.
   Inouye, Michael
   Havulinna, Aki S.
   Tuomilehto, Jaakko
   Jousilahti, Pekka
   Niiranen, Teemu J.
   Cheng, Susan
   Jain, Mohit
   Salomaa, Veikko
TI A plasma metabolite score of three eicosanoids predicts incident type 2
   diabetes: a prospective study in three independent cohorts
SO BMJ OPEN DIABETES RESEARCH & CARE
LA English
DT Article
ID BETA-CELL FUNCTION; INSULIN-RESISTANCE; OXIDATIVE STRESS; TARGETING
   INFLAMMATION
AB Introduction Peptide markers of inflammation have been associated with the development of type 2 diabetes. The role of upstream, lipid-derived mediators of inflammation such as eicosanoids, remains less clear. The aim of this study was to examine whether eicosanoids are associated with incident type 2 diabetes.
   Research design & methods In the FINRISK (Finnish Cardiovascular Risk Study) 2002 study, a population-based sample of Finnish men and women aged 25-74 years, we used directed, non-targeted liquid chromatography-mass spectrometry to identify 545 eicosanoids and related oxylipins in the participants' plasma samples (n=8292). We used multivariable-adjusted Cox regression to examine associations between eicosanoids and incident type 2 diabetes. The significant independent findings were replicated in the Framingham Heart Study (FHS, n=2886) and Dietary, Lifestyle and Genetic determinants of Obesity and Metabolic syndrome (DILGOM) 2007 (n=3905). Together, these three cohorts had 1070 cases of incident type 2 diabetes.
   Results In the FINRISK 2002 cohort, 76 eicosanoids were associated individually with incident type 2 diabetes. We identified three eicosanoids independently associated with incident type 2 diabetes using stepwise Cox regression with forward selection and a Bonferroni-corrected inclusion threshold. A three-eicosanoid risk score produced an HR of 1.56 (95% CI 1.41 to 1.72) per 1 SD increment for risk of incident diabetes. The HR for comparing the top quartile with the lowest was 2.80 (95% CI 2.53 to 3.07). In the replication analyses, the three-eicosanoid risk score was significant in FHS (HR 1.24 (95% CI 1.10 to 1.39, p<0.001)) and directionally consistent in DILGOM (HR 1.12 (95% CI 0.99 to 1.27, p=0.07)). Meta-analysis of the three cohorts yielded a pooled HR of 1.31 (95% CI 1.05 to 1.56).
   Conclusions Plasma eicosanoid profiles predict incident type 2 diabetes and the clearest signals replicate in three independent cohorts. Our findings give new information on the biology underlying type 2 diabetes and suggest opportunities for early identification of people at risk.
C1 [Tuomisto, Karolina; Tuomilehto, Jaakko] Univ Helsinki, Dept Publ Hlth, Helsinki, Finland.
   [Tuomisto, Karolina; Palmu, Joonatan; Havulinna, Aki S.; Tuomilehto, Jaakko; Jousilahti, Pekka; Niiranen, Teemu J.; Salomaa, Veikko] Finnish Inst Hlth & Welf, Dept Publ Hlth & Welf, Helsinki, Finland.
   [Palmu, Joonatan; Niiranen, Teemu J.] Univ Turku, Dept Internal Med, Turku, Finland.
   [Long, Tao; Watrous, Jeramie D.; Mercader, Kysha; Lagerborg, Kim A.; Andres, Allen; Jain, Mohit] Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA.
   [Long, Tao; Watrous, Jeramie D.; Mercader, Kysha; Lagerborg, Kim A.; Andres, Allen; Jain, Mohit] Univ Calif San Diego, Dept Pharmacol, La Jolla, CA 92093 USA.
   [Salmi, Marko; Jalkanen, Sirpa] Univ Turku, InFLAMES Flagship, MediCity, Turku, Finland.
   [Salmi, Marko; Jalkanen, Sirpa] Univ Turku, Inst Biomed, Turku, Finland.
   [Vasan, Ramachandran S.] Boston Univ, Framingham, MA USA.
   [Vasan, Ramachandran S.] Natl Heart Lung & Blood Inst Framingham Heart Stu, Framingham, MA USA.
   [Vasan, Ramachandran S.] Boston Univ, Sch Med, Dept Med, Sect Prevent Med & Epidemiol & Cardiovasc Med, Boston, MA 02118 USA.
   [Inouye, Michael] Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge Baker Syst Genom Initiat, Cambridge, England.
   [Inouye, Michael] Baker Heart & Diabet Inst, Cambridge Baker Syst Genom Initiat, Melbourne, Vic, Australia.
   [Havulinna, Aki S.] Univ Helsinki, Inst Mol Med Finland, Helsinki, Finland.
   [Cheng, Susan] Cedars Sinai Med Ctr, Smidt Heart Inst, Los Angeles, CA 90048 USA.
C3 University of Helsinki; University of Turku; University of California
   System; University of California San Diego; University of California
   System; University of California San Diego; University of Turku;
   University of Turku; Boston University; Framingham Heart Study; National
   Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood
   Institute (NHLBI); Boston University; University of Cambridge;
   University of Helsinki; Cedars Sinai Medical Center
RP Tuomisto, K (corresponding author), Univ Helsinki, Dept Publ Hlth, Helsinki, Finland.; Tuomisto, K (corresponding author), Finnish Inst Hlth & Welf, Dept Publ Hlth & Welf, Helsinki, Finland.
EM karolina.tuomisto@helsinki.fi
RI Salomaa, Veikko/AEO-8209-2022; Inouye, Michael/LSL-2558-2024; Havulinna,
   Aki/AAM-4769-2021; tuomilehto, jaakko/E-6504-2011; Cheng,
   Chi-An/AAD-7706-2022; Tuomisto, Karolina/LIH-5904-2024; Ramachandran,
   Vasan/Y-2527-2019; Niiranen, Teemu/R-1507-2017
OI Cheng, Susan/0000-0002-4977-036X; Niiranen, Teemu/0000-0002-7394-7487;
   Inouye, Michael/0000-0001-9413-6520; Palmu, Joonatan/0000-0003-0059-3347
FU Paavo Nurmi Foundation; Aarne Koskelo Foundation; Emil Aaltonen
   Foundation; Finnish Medical Foundation; Academy of Finland [141136,
   321356, 321351, 46558]; Finnish Foundation for Cardiovascular Research;
   US National Institutes of Health, NIH [S10OD020025, R01ES027595,
   K01DK116917]; National Heart, Lung and Blood Institute's Framingham
   Heart Study [N01-HC-25195, HHSN268201500001I, 75N92019D00031]; Evans
   Scholar award; Jay and Louis Coffman Foundation from the Department of
   Medicine, Boston University School of Medicine; Social Insurance
   Institution of Finland; Future Forum, Astra Zeneca; Eli Lilly Finland;
   Academy of Finland (AKA) [141136] Funding Source: Academy of Finland
   (AKA); National Institute of Diabetes and Digestive and Kidney Diseases
   [K01DK116917] Funding Source: NIH RePORTER; National Institute of
   Environmental Health Sciences [R01ES027595] Funding Source: NIH RePORTER
FX This work was supported by Paavo Nurmi, Aarne Koskelo, Emil Aaltonen and
   Finnish Medical Foundations, and Academy of Finland (#141136 to MS and
   SJ; #321356 to ASH; #321351 to TJN; #46558 to JT). VS was supported by
   the Finnish Foundation for Cardiovascular Research. MJ and JDW were
   supported by grants from the US National Institutes of Health, including
   NIH S10OD020025 and R01ES027595 to MJ and K01DK116917 to JDW. This work
   was partially supported by the National Heart, Lung and Blood
   Institute's Framingham Heart Study (contracts N01-HC-25195,
   HHSN268201500001I and 75N92019D00031). RSV is supported by an Evans
   Scholar award and Jay and Louis Coffman Foundation from the Department
   of Medicine, Boston University School of Medicine. The glucose tolerance
   testing in this work was supported by the grants to JT from Academy of
   Finland (grant 46558); the Social Insurance Institution of Finland; the
   Future Forum, Astra Zeneca and Eli Lilly Finland.
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   Vos T, 2015, LANCET, V386, P743, DOI 10.1016/S0140-6736(15)60692-4
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NR 40
TC 16
Z9 16
U1 0
U2 1
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
EI 2052-4897
J9 BMJ OPEN DIAB RES CA
JI BMJ Open Diab. Res. Care
PD MAR
PY 2022
VL 10
IS 2
AR e002519
DI 10.1136/bmjdrc-2021-002519
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 0F8RW
UT WOS:000777624100001
PM 35361620
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU de Oliveira, C
   Sabbah, W
   Schneider, IJC
   Bernabé, E
AF de Oliveira, Cesar
   Sabbah, Wael
   Ceola Schneider, Ione Jayce
   Bernabe, Eduardo
TI Complete Tooth Loss and Allostatic Load Changes Later in Life: A 12-Year
   Follow-Up Analysis of the English Longitudinal Study of Ageing
SO PSYCHOSOMATIC MEDICINE
LA English
DT Article
DE tooth loss; allostatic load; biomarkers; metabolism; fruit and vegetable
   consumption; aging; AL = allostatic load; CI = confidence interval; ELSA
   = English Longitudinal Study of Ageing; LME = linear mixed effects; SD =
   standard deviation
ID METABOLIC SYNDROME; ORAL-HEALTH; OLDER AGES; ASSOCIATIONS; POPULATION;
   NUTRITION; DISEASE; STRESS; NUMBER; TEETH
AB Objective
   There is little evidence of the association between complete tooth loss and allostatic load (AL). We investigated, firstly, the association between complete tooth loss and changes in AL for 12 years among older English adults. A second aim was to explore the role of fruit and vegetable consumption in explaining the aforementioned association. Methods
   AL was calculated for 2430 English Longitudinal Study of Ageing cohort (2004/5-2016/17) participants 50 years and older based on nine biomarkers: systolic and diastolic blood pressures, glycated hemoglobin, high- and low-density lipoprotein cholesterol, triglycerides, fibrinogen, C-reactive protein, and waist circumference. The exposure was complete tooth loss. Participants were classified as dentate or edentulous. A linear mixed-effects model was fitted to model the 12-year change in AL score and its association with complete tooth loss after adjustments for confounders (demographic factors, socioeconomic position, and health behaviors). Results
   Around 11% of the participants were edentulous. Complete tooth loss was positively associated with baseline AL scores but not with its rate of change over time. The predicted mean AL scores were 3.60 (95% confidence interval [CI] = 3.53-3.68) and 3.98 (95% CI = 3.76-4.21) as well as 4 center dot 28 (95% CI = 4 center dot 18, 4 center dot 39) and 4 center dot 66 (95% CI = 4 center dot 42, 4 center dot 90) for dentate and edentulous participants, at baseline and end of follow-up, respectively. Fruit and vegetable consumption was not associated with baseline AL or its rate of change. Conclusions
   Complete tooth loss was associated with baseline AL score but not with its development over time, whereas the consumption of fruit and vegetables did not help to explain this association. Both conditions may share common determinants earlier in life.
C1 [de Oliveira, Cesar] UCL, Dept Epidemiol & Publ Hlth, English Longitudinal Study Ageing ELSA, 1-19 Torrington Pl, London WC1E 6BT, England.
   [Sabbah, Wael; Bernabe, Eduardo] Kings Coll London, Dent Inst, Div Populat & Patient Hlth, London, England.
   [Ceola Schneider, Ione Jayce] Univ Fed Santa Catarina, Hlth Sci Dept, Ararangua, SC, Brazil.
   [Ceola Schneider, Ione Jayce] Univ Fed Santa Catarina, Rehabil Postgrad Program, Ararangua, SC, Brazil.
C3 University of London; University College London; University of London;
   King's College London; Universidade Federal de Santa Catarina (UFSC);
   Universidade Federal de Santa Catarina (UFSC)
RP de Oliveira, C (corresponding author), UCL, Dept Epidemiol & Publ Hlth, English Longitudinal Study Ageing ELSA, 1-19 Torrington Pl, London WC1E 6BT, England.
EM c.oliveira@ucl.ac.uk
RI Schneider, Ione/J-8762-2013; Sabbah, Wael/AAF-3460-2019; de Oliveira,
   Cesar/B-5251-2019; Bernabe, Eduardo/R-3441-2017
OI De Oliveira, Cesar/0000-0002-4099-4762; Bernabe,
   Eduardo/0000-0002-1858-3713
FU National Institute on Aging [R01AG017644]; consortium of UK government
   departments by the Economic and Social Research Council
FX The English Longitudinal Study of Ageing was developed by a team of
   researchers based at the University College London, NatCen Social
   Research, the Institute for Fiscal Studies, and the University of
   Manchester. The data were collected by NatCen Social Research. The
   funding is provided by National Institute on Aging Grant R01AG017644 and
   a consortium of UK government departments coordinated by the Economic
   and Social Research Council. The funders had no involvement in the
   article. The authors declare that they have no conflict of interest.
CR Ben-Shlomo Y, 2016, INT J EPIDEMIOL, V45, P973, DOI 10.1093/ije/dyw096
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NR 35
TC 3
Z9 3
U1 2
U2 9
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0033-3174
EI 1534-7796
J9 PSYCHOSOM MED
JI Psychosom. Med.
PD APR
PY 2021
VL 83
IS 3
BP 247
EP 255
DI 10.1097/PSY.0000000000000925
PG 9
WC Psychiatry; Psychology; Psychology, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry; Psychology
GA RM1CN
UT WOS:000639398400006
PM 33657084
OA Green Submitted, hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Hu, L
   Peng, X
   Qin, LL
   Wang, R
   Fang, ZF
   Lin, Y
   Xu, SY
   Feng, B
   Wu, D
   Che, LQ
AF Hu, Liang
   Peng, Xie
   Qin, Linlin
   Wang, Ru
   Fang, Zhengfeng
   Lin, Yan
   Xu, Shengyu
   Feng, Bin
   Wu, De
   Che, Lianqiang
TI Dietary nucleotides supplementation during the suckling period improves
   the antioxidative ability of neonates with intrauterine growth
   retardation when using a pig model
SO RSC ADVANCES
LA English
DT Article
ID OXIDATIVE STRESS; IMMUNE FUNCTION; DNA-DAMAGE; METABOLIC SYNDROME;
   MITOCHONDRIAL-DNA; GENE-EXPRESSION; FREE-RADICALS; RESTRICTION;
   PERFORMANCE; CAPACITY
AB The aim of the present study was to investigate the effect of dietary nucleotides supplementation on the antioxidant status of piglets affected by intrauterine growth retardation (IUGR). Fourteen pairs of normal birth weight (NBW) and IUGR piglets were fed either a control diet (CON) or a nucleotides supplementation diet (NT) from 7 d of age to 28 d postnatal. Blood, liver and jejunum samples were collected at the end of the study. The results showed that IUGR piglets had decreased (P < 0.05) concentrations of plasma total antioxidant capability (T-AOC) and total superoxide dismutase (T-SOD), gene expressions of hepatic cytoplasmic copper/zinc SOD (CuZnSOD) and PPAR gamma coactivator-1 alpha (PGC-1 alpha) and jejunal glutathione peroxidase (GP(X)) and extracellular superoxide dismutase (ESOD), accordingly, there was markedly higher (P < 0.05) plasma malondialdehyde (MDA) and hepatic and jejunal mitochondria DNA content in the IUGR piglets relative to NBW piglets. Regardless of body weight, dietary NT supplementation significantly increased (P < 0.05) plasma concentrations of T-AOC, T-SOD, CuZnSOD, GP(X) and the ratio of reduced glutathione to oxidized glutathione, hepatic T-SOD, GPX and mitochondria DNA content, while hepatic MDA concentration was markedly decreased (P < 0.05) 19.1% by NT diet. Furthermore, the gene expressions of hepatic glutathione reductase, CuZnSOD, nuclear erythroid 2-related factor 2, PGC-1 alpha and nuclear respiratory factor-1 (NRF-1) and jejunal GP(X), CuZnSOD, ESOD and NRF-1 were significantly increased (P < 0.05) by NT diet, whereas the gene expression of Kelch-like ECH-associated protein 1 were markedly decreased (P < 0.05) compared with that of piglets fed with CON diet. These results indicate that dietary NT supplementation prevents the effect of IUGR on oxidative status and mitochondria DNA damage through improving the non-enzymatic and enzymatic antioxidant capacities as well as mitochondria biogenesis of piglets.
C1 [Hu, Liang; Peng, Xie; Qin, Linlin; Wang, Ru; Fang, Zhengfeng; Lin, Yan; Xu, Shengyu; Feng, Bin; Wu, De; Che, Lianqiang] Sichuan Agr Univ, Inst Anim Nutr, 211 Huimin Rd, Chengdu 611130, Sichuan, Peoples R China.
   [Hu, Liang; Peng, Xie; Qin, Linlin; Wang, Ru; Fang, Zhengfeng; Lin, Yan; Xu, Shengyu; Feng, Bin; Wu, De; Che, Lianqiang] China Minist Educ, Key Lab Anim Dis Resistance Nutr, Chengdu 611130, Sichuan, Peoples R China.
C3 Sichuan Agricultural University; Ministry of Education - China
RP Che, LQ (corresponding author), Sichuan Agr Univ, Inst Anim Nutr, 211 Huimin Rd, Chengdu 611130, Sichuan, Peoples R China.; Che, LQ (corresponding author), China Minist Educ, Key Lab Anim Dis Resistance Nutr, Chengdu 611130, Sichuan, Peoples R China.
EM clianqiang@hotmail.com
RI Feng, Bin/GLU-0109-2022; Xu, Shengyu/AFN-8288-2022; Qin,
   linlin/HLX-3613-2023
OI Wu, De/0000-0003-1873-9914; hu, liang/0000-0001-5263-9314
FU National Key Research and Development Program of China [2016YFD0501204];
   Sichuan provincial project on S&T application and demonstration
   [2016CC0070]
FX The authors thank Jian Zhang, Chuan Yan, Qin Xu, Cheng Wu and Liu Yan
   for their excellent technical assistance. This work was supported by the
   National Key Research and Development Program of China (grant no.
   2016YFD0501204) and Sichuan provincial project on S&T application and
   demonstration (grant no. 2016CC0070).
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NR 61
TC 12
Z9 12
U1 0
U2 9
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
EI 2046-2069
J9 RSC ADV
JI RSC Adv.
PY 2018
VL 8
IS 29
BP 16152
EP 16160
DI 10.1039/c8ra00701b
PG 9
WC Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry
GA GF3AF
UT WOS:000431814200035
PM 35542194
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Yoon, CG
   Kang, MY
   Bae, KJ
   Yoon, JH
AF Yoon, Chang-Gyo
   Kang, Mo-Yeol
   Bae, Kyu-Jung
   Yoon, Jin-Ha
TI Do Working Hours and Type of Work Affect Obesity in South Korean Female
   Workers? Analysis of the Korean Community Health Survey
SO JOURNAL OF WOMENS HEALTH
LA English
DT Article
ID SHORT-SLEEP DURATION; BODY-MASS INDEX; SOCIOECONOMIC-STATUS; METABOLIC
   SYNDROME; CHRONIC STRESS; LEPTIN LEVELS; FOOD CHOICE; WEIGHT-GAIN;
   ADULTS; ASSOCIATION
AB Background: The prevalence of obesity and the female labor participation rate have been rapidly increasing in South Korea. To examine the relationship between these factors, we investigated the association between timing and type of work and obesity in the Korean female working population. Methods: Data collected by the 2008 Community Health Survey (CHS) were analyzed using a complex, stratified, multistage, probability cluster sampling method. Descriptive analysis of relevant variables was performed using the chi-square test, and work-related variables by work type were identified using multivariate logistic regression. The relationship between long working hours, night/shift work, and body-mass index in female workers and explanatory, stratifying, and dependent variables and covariates was analyzed using multiple logistic regression models. Results: A total of 42,234 CHS participants were eligible for study inclusion. Among both manual and nonmanual workers, working less than 40 (adjusted odds ratio [aOR] 1.18, 95% confidence interval [CI] 1.07-1.31 and aOR 1.29; 95% CI 1.09-0.52, respectively) or more than 60 (aOR 1.18, 95% CI 1.06-1.30 and aOR 1.28, 95% CI 1.04-1.57, respectively) hours per week was significantly associated with obesity after controlling for covariates. However, working type (day or night/shift) was significantly associated with obesity only in nonmanual workers (aOR 1.20, 95% CI 1.01-1.42). When we controlled working type in the model, manual workers who work more than 60 hours show higher likelihood of being obese (OR 1.10, 95% CI 1.02-1.18). Conclusion: Working fewer (<40) or more than (>60) hours per week is significantly associated with obesity in the Korean female working population, regardless of the type of work. The type of work (day vs. night/shift work) was significantly associated with obesity only in only nonmanual workers.
C1 [Yoon, Chang-Gyo; Bae, Kyu-Jung] Armed Forces Med Command, Dept Prevent Med, Songnam, South Korea.
   [Kang, Mo-Yeol] Occupat Safety & Hlth Res Inst, Ulsan, South Korea.
   [Kang, Mo-Yeol] Seoul Natl Univ, Coll Med, Dept Prevent Med, Seoul, South Korea.
   [Yoon, Jin-Ha] Yonsei Univ, Coll Med, Inst Occupat Hlth, Seoul 120749, South Korea.
   [Yoon, Jin-Ha] Yonsei Univ, Coll Med, Dept Prevent Med, 50 Yonsei Ro, Seoul 120749, South Korea.
C3 Seoul National University (SNU); Yonsei University; Yonsei University
   Health System; Yonsei University; Yonsei University Health System
RP Yoon, JH (corresponding author), Yonsei Univ, Coll Med, Dept Prevent Med, 50 Yonsei Ro, Seoul 120749, South Korea.
EM flyinyou@gmail.com
RI Yoon, Changgyo/F-7515-2011
OI Yoon, Jin-Ha/0000-0003-4198-2955
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NR 39
TC 12
Z9 16
U1 0
U2 9
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-9996
EI 1931-843X
J9 J WOMENS HEALTH
JI J. Womens Health
PD FEB 1
PY 2016
VL 25
IS 2
BP 173
EP 180
DI 10.1089/jwh.2014.5161
PG 8
WC Public, Environmental & Occupational Health; Medicine, General &
   Internal; Obstetrics & Gynecology; Women's Studies
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; General & Internal
   Medicine; Obstetrics & Gynecology; Women's Studies
GA DD0GV
UT WOS:000369599300010
PM 26667030
DA 2025-06-11
ER

PT J
AU Buscemi, S
   Cosentino, L
   Rosafio, G
   Morgana, M
   Mattina, A
   Sprini, D
   Verga, S
   Rini, GB
AF Buscemi, Silvio
   Cosentino, Loretta
   Rosafio, Giuseppe
   Morgana, Manuela
   Mattina, Alessandro
   Sprini, Delia
   Verga, Salvatore
   Rini, Giovam Battista
TI Effects of hypocaloric diets with different glycemic indexes on
   endothelial function and glycemic variability in overweight and in obese
   adult patients at increased cardiovascular risk
SO CLINICAL NUTRITION
LA English
DT Article
DE Endothelial function; Glycemic variability; Diet; Glycemic index;
   Glycemic load; Cardiovascular risk
ID FLOW-MEDIATED DILATION; CORONARY-HEART-DISEASE; POSTMENOPAUSAL WOMEN;
   METABOLIC SYNDROME; OXIDATIVE STRESS; WEIGHT-LOSS; LOAD; CARBOHYDRATE;
   CHOLESTEROL; MAINTENANCE
AB Background & aims: The role of glycemic index of the diet in glucose control and cardiovascular prevention is still not clear. The aim of this study was to determine the effects of hypocaloric diets with different glycemic indexes and glycemic loads on endothelial function and glycemic variability in nondiabetic participants at increased cardiovascular risk.
   Methods: Forty nondiabetic obese participants were randomly assigned to a three-month treatment with either a low glycemic index (LGI; n = 19) or high glycemic index (HGI; n = 21) hypocaloric diet with similar macronutrient and fiber content. Endothelial function was measured as flow-mediated dilatation (FMD) of the brachial artery before and after dieting. In addition, 48-h continuous subcutaneous glucose monitoring was done before and after dieting in a subgroup of 24 participants.
   Results: The amount of weight loss after dieting was similar in both groups. The glycemic index of the diet significantly influenced the FMD (P < 0.005). In particular, the change of FMD was 2.3 +/- 2.6% following the LGI diet, and -0.9 +/- 3.6% after the HGI diet (P < 0.005). The mean 48-h glycemia decreased significantly after dietary treatment (P < 0.05), but no significant effect of the glycemic index of the diet on results was observed. The glycemic index of the diet significantly influenced the 48-h glycemic variability measured as coefficient of variability (CV%; P < 0.001). The CV% decreased after the LGI diet (from 23.5 to 20.0%) and increased after the HGI diet (from 23.6 to 26.6%). The change in percentage of FMD was inversely correlated with the change in the 48-h glycemic CV% (r = -0.45; P < 0.05).
   Conclusions: Endothelial function and glycemic variability ameliorate in association with the adherence to an LGI hypocaloric diet in nondiabetic obese persons. Clinical trial registration number: ISRCTN56834511. (C) 2012 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.
C1 [Buscemi, Silvio; Cosentino, Loretta; Rosafio, Giuseppe; Morgana, Manuela; Mattina, Alessandro; Sprini, Delia; Verga, Salvatore; Rini, Giovam Battista] Univ Palermo, Policlin P Giaccone, Dipartimento Med Interna & Specialist DIMIS, Lab Nutr Clin,Fac Med, I-90127 Palermo, Italy.
C3 University of Palermo
RP Buscemi, S (corresponding author), Univ Palermo, Policlin P Giaccone, Dipartimento Med Interna & Specialist DIMIS, Lab Nutr Clin,Fac Med, Via Vespro 129, I-90127 Palermo, Italy.
EM silbus@tin.it
RI buscemi, silvio/K-9662-2016; Mattina, Alessandro/F-6020-2019
OI buscemi, silvio/0000-0003-0730-7649; VERGA,
   Salvatore/0000-0002-7743-7847; Mattina, Alessandro/0000-0003-3458-0894
CR Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
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NR 30
TC 36
Z9 41
U1 0
U2 16
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0261-5614
J9 CLIN NUTR
JI Clin. Nutr.
PD JUN
PY 2013
VL 32
IS 3
BP 346
EP 352
DI 10.1016/j.clnu.2012.10.006
PG 7
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 161UN
UT WOS:000320218900005
PM 23111004
DA 2025-06-11
ER

PT J
AU Shiao, TH
   Liu, CJ
   Luo, JC
   Su, KC
   Chen, YM
   Chen, TJ
   Chou, KT
   Shiao, GM
   Lee, YC
AF Shiao, Tsu-Hui
   Liu, Chia-Jen
   Luo, Jiing-Chyuan
   Su, Kang-Cheng
   Chen, Yuh-Min
   Chen, Tzeng-Ji
   Chou, Kun-Ta
   Shiao, Guang-Ming
   Lee, Yu-Chin
TI Sleep Apnea and Risk of Peptic Ulcer Bleeding: A Nationwide
   Population-based Study
SO AMERICAN JOURNAL OF MEDICINE
LA English
DT Article
DE Intermittent hypoxia; Peptic ulcer bleeding; Sleep apnea;
   Sleep-disordered breathing
ID HELICOBACTER-PYLORI INFECTION; CHRONIC INTERMITTENT HYPOXIA;
   GASTROESOPHAGEAL-REFLUX DISEASE; POSITIVE AIRWAY PRESSURE; MUCOSAL
   DEFENSE; HEART HEALTH; INSULIN-RESISTANCE; METABOLIC SYNDROME; OXIDATIVE
   STRESS; LIVER-INJURY
AB OBJECTIVE: Patients with sleep apnea sustain cessation of breath during sleep, leading to intermittent hypoxia, systemic inflammation, and sympathetic activation. These insults may contribute to initiation or progression of peptic ulcers. This retrospective matched-control cohort study explored the relationship of sleep apnea and subsequent development of peptic ulcer bleeding.
   METHODS: From 2000 to 2009, patients with newly diagnosed sleep apnea were identified from the Taiwan National Health Insurance Research Database. A control group without sleep apnea, matched for age, gender, comorbidities, and medications, was selected for comparison. In both groups, subjects with history of peptic ulcer bleeding, nonspecific gastrointestinal bleeding, or malignancy were excluded. The 2 cohorts were followed up and observed for occurrence of peptic ulcer bleeding.
   RESULTS: Of the 35,480 sampled patients (7096 patients with sleep apnea vs 28,384 controls), 84 (0.24%) experienced peptic ulcer bleeding during a follow-up period of 3.57 +/- 2.61 years, including 32 (0.45% of patients with sleep apnea) from the sleep apnea cohort and 52 (0.18% of control) from the control group (log-rank test, P < .0001). In comparison with subjects without development of peptic ulcer bleeding, those with peptic ulcer bleeding were older and had a higher percentage of sleep apnea, coronary artery disease, peptic ulcer, ischemic stroke, and medication for nonsteroidal anti-inflammatory drugs. By Cox regression analysis, sleep apnea, older age, and peptic ulcer history were independent predictors of peptic ulcer bleeding. Patients with sleep apnea experienced a 2.400-fold (95% confidence interval, 1.544-3.731; P < .001) higher risk for incident peptic ulcer bleeding after adjusting for other variables.
   CONCLUSIONS: Sleep apnea may be an independent risk factor for peptic ulcer bleeding. (C) 2013 Elsevier Inc. All rights reserved. The American Journal of Medicine (2013) 126, 249-255
C1 [Shiao, Tsu-Hui; Su, Kang-Cheng; Chen, Yuh-Min; Chou, Kun-Ta; Shiao, Guang-Ming; Lee, Yu-Chin] Taipei Vet Gen Hosp, Dept Chest Med, Taipei 112, Taiwan.
   [Liu, Chia-Jen] Taipei Vet Gen Hosp, Div Oncol, Dept Med, Taipei 112, Taiwan.
   [Luo, Jiing-Chyuan] Taipei Vet Gen Hosp, Div Gastroenterol, Dept Med, Taipei 112, Taiwan.
   [Chen, Tzeng-Ji] Taipei Vet Gen Hosp, Dept Family Med, Taipei 112, Taiwan.
   [Su, Kang-Cheng] Natl Yang Ming Univ, Inst Emergency & Crit Care Med, Taipei 112, Taiwan.
   [Liu, Chia-Jen; Chen, Yuh-Min; Shiao, Guang-Ming; Lee, Yu-Chin] Natl Yang Ming Univ, Fac Med, Sch Med, Taipei 112, Taiwan.
   [Chen, Tzeng-Ji] Natl Yang Ming Univ, Inst Hosp & Hlth Care Adm, Sch Med, Taipei 112, Taiwan.
   [Chou, Kun-Ta] Natl Yang Ming Univ, Inst Clin Med, Sch Med, Taipei 112, Taiwan.
   [Liu, Chia-Jen] Natl Yang Ming Univ Hosp, Dept Internal Med, Yilan, Taiwan.
   [Liu, Chia-Jen] Natl Yang Ming Univ, Inst Publ Hlth, Taipei 112, Taiwan.
C3 Taipei Veterans General Hospital; Taipei Veterans General Hospital;
   Taipei Veterans General Hospital; Taipei Veterans General Hospital;
   National Yang Ming Chiao Tung University; National Yang Ming Chiao Tung
   University; National Yang Ming Chiao Tung University; National Yang Ming
   Chiao Tung University; National Yang Ming Chiao Tung University
RP Chou, KT (corresponding author), Taipei Vet Gen Hosp, Dept Chest Med, 201,Sec 2,Shih Pai Rd, Taipei 112, Taiwan.
EM hbjoue@vghtpe.gov.tw
RI Chou, Kun-Ta/I-1433-2019; Su, Kang-Cheng/MGA-2675-2025; Chen,
   TJ/AAH-8430-2021
OI Chou, Kun-Ta/0000-0002-4822-5474
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NR 51
TC 41
Z9 41
U1 0
U2 7
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0002-9343
EI 1555-7162
J9 AM J MED
JI Am. J. Med.
PD MAR
PY 2013
VL 126
IS 3
BP 249
EP U106
DI 10.1016/j.amjmed.2012.08.017
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 088YM
UT WOS:000314873800025
PM 23410566
DA 2025-06-11
ER

PT J
AU Cortijo-Alfonso, ME
   Romero, MP
   Macia, A
   Yuste, S
   Moralejo, M
   Rubió-Piqué, L
   Pinol-Felis, C
AF Cortijo-Alfonso, Maria-Engracia
   Romero, Maria-Paz
   Macia, Alba
   Yuste, Silvia
   Moralejo, Marian
   Rubio-Pique, Laura
   Pinol-Felis, Carme
TI Effect of Barley and Oat Consumption on Immune System, Inflammation and
   Gut Microbiota: A Systematic Review of Randomized Controlled Trials
SO CURRENT NUTRITION REPORTS
LA English
DT Review
DE Barley; beta-glucans; Gut microbiota; Immune function; Inflammation;
   Systematic review; Oats
ID BETA-GLUCANS; INSULIN SENSITIVITY; OXIDATIVE STRESS; MARKERS;
   POLYPHENOLS; HEALTHY; BENEFITS; HORMONES; IMPACT; FOODS
AB Purpose of Review The aim of this systematic review was to investigate the effects of whole grain Avena sativa and Hordeum vulgare L., or their isolated fractions, on immune and inflammatory functions, as well as their influence on gut microbiota. A structured literature search was undertaken in line with PRISMA guidelines. Randomized controlled trials (RCTs) that investigated the effects of oats or barley consumption in adults and reported >= 1 of the following: C-reactive protein (CRP), tumor necrosis factor (TNF-alpha), interleukin-6 (IL-6), IL-2, IL-8, IL-18, lipopolysacharide binding protein (LBP) or gut microbiota-related outcomes, were included.Recent Findings A total of 16 RCTs were included, among which 6 studies recruited metabolically at-risk population, including individuals with overweight and obesity, metabolic syndrome or hypercholesterolemia. Additionally, 3 trials involved young healthy population, 5 trials targeted older individuals (aged over 50 years), and 2 studies encompassed populations with other disease states. A total of 1091 individuals were included in the evaluation of short-term (up to 14 days) and long-term (beyond 14 days, up to 90 days) supplementation with oats or barley-based products. 9 studies measured inflammatory biomarkers and 5 of them reported significant reductions, specifically in long-term studies. Notably, no evidence of anti-inflammatory benefits was found in healthy individuals, whereas studies involving metabolically at-risk populations showed promising reductions in inflammation. 13 studies measured the impact on gut microbiota, and collectively suggest that oats and barley food products can influence the composition of gut microbiota, associated in some cases with metabolic improvements.Summary Oats and barley consumption may confer anti-inflammatory effects in metabolically at-risk populations and influence gut microbiota outcomes. However, no anti-inflammatory benefits were observed in healthy individuals. Results from this systematic review suggests caution in interpreting findings due to limited trials and variations in interventions and health conditions.
C1 [Cortijo-Alfonso, Maria-Engracia; Romero, Maria-Paz; Macia, Alba; Yuste, Silvia; Moralejo, Marian; Rubio-Pique, Laura] Univ Lleida, Agrotecnio CERCA Ctr, Ave Alcalde Rovira Roure 191, Lleida 25198, Spain.
   [Pinol-Felis, Carme] Univ Lleida, Dept Med & Surg, Lleida, Catalonia, Spain.
   [Pinol-Felis, Carme] Inst Recerca Biomed Lleida Fundacio Dr Pifarre IRB, Lleida, Catalonia, Spain.
C3 Universitat de Lleida; Universitat de Lleida
RP Rubió-Piqué, L (corresponding author), Univ Lleida, Agrotecnio CERCA Ctr, Ave Alcalde Rovira Roure 191, Lleida 25198, Spain.
EM laura.rubio@udl.cat
RI Rubió Piqué, Laura/GWZ-4541-2022; Macià, Alba/L-6292-2014; Moralejo,
   Marian/L-5351-2014; Pérez, Silvia/AAU-7275-2021; Romero-Fabregat,
   Maria-Paz/H-3431-2011
OI Romero-Fabregat, Maria-Paz/0000-0001-9892-4874; Moralejo,
   Marian/0000-0003-4667-6770; Yuste Perez, Silvia/0000-0003-0775-2179
FU Agency for Management of University and Research Grants (AGAUR) from
   Generalitat de Catalunya
FX No Statement Available
CR Afzaal M, 2022, FRONT MICROBIOL, V13, DOI 10.3389/fmicb.2022.999001
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NR 65
TC 4
Z9 4
U1 3
U2 10
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
EI 2161-3311
J9 CURR NUTR REP
JI Curr. Nutr. Rep.
PD SEP
PY 2024
VL 13
IS 3
BP 582
EP 597
DI 10.1007/s13668-024-00543-x
EA MAY 2024
PG 16
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA C7R9F
UT WOS:001235727000001
PM 38789888
OA hybrid
DA 2025-06-11
ER

PT J
AU Han, X
   Lv, ZQ
   He, MA
   Cheng, JQ
   Zhang, YW
   Wang, T
   Chen, JX
   Liu, YW
   Hu, DS
   Wu, XL
   Zhai, RH
   Huang, H
   Huang, SL
AF Han, Xu
   Lv, Ziquan
   He, Mei'an
   Cheng, Jinquan
   Zhang, Yanwei
   Wang, Tian
   Chen, Jiaxin
   Liu, Yuewei
   Hu, Dongsheng
   Wu, Xuli
   Zhai, Rihong
   Huang, Hui
   Huang, Suli
TI Effects of multiple metals exposure on abnormal liver function: The
   mediating role of low-density lipoprotein cholesterol
SO ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
LA English
DT Article
DE plasma metals; liver function; dose -response relationship; mediation
   analysis
ID OXIDATIVE STRESS; METABOLIC SYNDROME; NATIONAL-HEALTH; HEAVY-METALS;
   HEPATOCYTES; APOPTOSIS; CADMIUM; RISK; SILYMARIN; AUTOPHAGY
AB Equilibration of metal metabolism is critical for normal liver function. Most epidemiological studies have only concentrated on the influence of limited metals. However, the single and synergistic impact of multiple-metal exposures on abnormal liver function (ALF) are still unknown. A cross-sectional study involving 1493 Chinese adults residing in Shenzhen was conducted. Plasma concentrations of 13 metals, including essential metals (calcium, copper, cobalt, iron, magnesium, manganese, molybdenum, zinc, and selenium) and toxic metals (aluminum, cadmium, arsenic, and thallium) were detected by the inductively coupled plasma spectrometry (ICP-MS). ALF was ascertained as any observed abnormality from albumin, alanine transaminase, aspartate transaminase, gamma-glutamyl transpeptidase, and direct bilirubin. Diverse statistical methods were used to evaluate the single and mixture effect of metals, as well as the dose-response relationships with ALF risk, respectively. Mediation analysis was conducted to evaluate the role of blood lipids in the relation of metal exposure with ALF. The average age of subjects was 59.7 years, and 56.7 % were females. Logistic regression and the least absolute shrinkage and selection operator (LASSO) penalized regression model consistently suggested that increased levels of arsenic, aluminum, manganese, and cadmium were related to elevated risk of ALF; while magnesium and zinc showed protective effects on ALF (all p-trend < 0.05). The grouped weighted quantile sum (GWQS) regression revealed that the WQS index of essential metals and toxic metals showed significantly negative or positive relationship with ALF, respectively. Aluminum, arsenic, cadmium, and manganese showed linear whilst magnesium and zinc showed non-linear dose-response relationships with ALF risk. Mediation analysis showed that LDL-c mediated 4.41 % and 14.74 % of the relationship of plasma cadmium and manganese with ALF, respectively. In summary, plasma aluminum, arsenic, manganese, cadmium, magnesium, and zinc related with ALF, and LDL-c might underlie the pathogenesis of ALF associated with cadmium and manganese exposure. This study may provide critical public health significances in liver injury prevention and scientific evidence for the establishment of environmental standard.
C1 [Han, Xu; Hu, Dongsheng; Wu, Xuli; Zhai, Rihong; Huang, Suli] Shenzhen Univ, Med Sch, Sch Publ Hlth, Shenzhen 518055, Guangdong, Peoples R China.
   [Lv, Ziquan; Cheng, Jinquan; Zhang, Yanwei; Wang, Tian; Chen, Jiaxin; Huang, Suli] Shenzhen Ctr Dis Control & Prevent, Shenzhen 518055, Guangdong, Peoples R China.
   [Han, Xu; He, Mei'an] Huazhong Univ Sci & Technol, Dept Occupat & Environm Hlth, Wuhan 430030, Hubei, Peoples R China.
   [Han, Xu; He, Mei'an] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Key Lab Environm Hlth, Wuhan 430030, Hubei, Peoples R China.
   [Liu, Yuewei] Sun Yat sen Univ, Sch Publ Hlth, Dept Epidemiol, Guangzhou 510080, Guangdong, Peoples R China.
   [Huang, Hui] Joint Lab Guangdong Hong Kong Macao Univ Nutr Meta, Affiliated Hosp 8, Dept Cardiol, Hong Kong 518303, Peoples R China.
C3 Shenzhen University; Shenzhen Center for Disease Control & Prevention
   (SZCDC); Huazhong University of Science & Technology; Huazhong
   University of Science & Technology; Sun Yat Sen University
RP Huang, SL (corresponding author), Shenzhen Univ, Med Sch, Sch Publ Hlth, Shenzhen 518055, Guangdong, Peoples R China.
EM huangsuli420@163.com
RI Liang, Chen/HNP-5916-2023; Liu, Yuewei/J-5147-2019
OI Liu, Yuewei/0000-0001-5970-4262
FU National Natural Science Foundation of China [81973004, 81903283,
   81502789]; Natural Science Foundation of Guangdong Province
   [2023A1515012744]; Natural Science Foundation of Shenzhen Municipality
   [JCYJ20220531102011027]
FX This study was financially supported by National Natural Science
   Foundation of China (81973004, 81903283, and 81502789) , Natural Science
   Foundation of Guangdong Province (2023A1515012744) , and Natural Science
   Foundation of Shenzhen Municipality (JCYJ20220531102011027) .
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NR 74
TC 3
Z9 3
U1 6
U2 17
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0147-6513
EI 1090-2414
J9 ECOTOX ENVIRON SAFE
JI Ecotox. Environ. Safe.
PD MAY
PY 2024
VL 276
AR 116283
DI 10.1016/j.ecoenv.2024.116283
EA APR 2024
PG 11
WC Environmental Sciences; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Toxicology
GA PV5Z6
UT WOS:001216884400001
PM 38574647
OA gold
DA 2025-06-11
ER

PT J
AU Valentin, B
   Maes-Festen, D
   Schoufour, J
   Oppewal, A
AF Valentin, B.
   Maes-Festen, D.
   Schoufour, J.
   Oppewal, A.
TI Sarcopenia predicts 5-year mortality in older adults with intellectual
   disabilities
SO JOURNAL OF INTELLECTUAL DISABILITY RESEARCH
LA English
DT Article
DE intellectual disabilities; mortality; older adults; sarcopenia
ID PHYSICAL-ACTIVITY; MUSCLE MASS; PEOPLE; FRAILTY; NUTRITION; FITNESS;
   INDEX
AB BackgroundPeople with intellectual disabilities (ID) have a lower life expectancy than their peers without ID. A contributing factor to the lower life expectancy and early mortality could be sarcopenia: low muscle mass and low muscle function. In the general population, sarcopenia strongly predicts early mortality, but this association is unknown in people with ID. Therefore, this study aims to explore the association between sarcopenia and 5-year mortality in older adults with ID. MethodsIn the Healthy Ageing and Intellectual Disabilities (HA-ID) study, the prevalence of sarcopenia was measured at baseline among 884 older adults (& GE;50 years) with ID. All-cause mortality was measured over a 5-year follow-up period. Univariable and multivariable Cox proportional hazard models were applied to determine the association between sarcopenia (no sarcopenia, pre-sarcopenia, sarcopenia, severe sarcopenia) and early mortality, adjusted for age, sex, level of ID, presence of Down syndrome, and co-morbidity (chronic obstructive pulmonary disease, diabetes type 2 and metabolic syndrome). ResultsThe unadjusted hazard ratio (HR) for sarcopenia was 2.28 [95% confidence interval (CI) 1.48-3.42], P < 0.001), and 2.40 (95% CI 1.40-4.10, P = 0.001) for severe sarcopenia. When adjusted for age, sex, level of ID, and Down syndrome, sarcopenia (HR = 1.72, 95% CI 1.08-2.75, P = 0.022) and severe sarcopenia (HR = 1.86, 95% CI 1.07-3.23, P = 0.028) were significantly associated with early mortality. When additionally adjusted for co-morbidity, the adjusted HR decreased to 1.62 (95% CI 1.02-2.59, P = 0.043) and 1.81 (95% CI 1.04-3.15, P = 0.035) for sarcopenia and severe sarcopenia, respectively. ConclusionSarcopenia is an independent risk factor for early mortality in older adults with ID over a 5-year follow-up period. Our results stress the need to delay the incidence and development of sarcopenia in older adults with ID.
C1 [Valentin, B.; Maes-Festen, D.; Oppewal, A.] Univ Med Ctr Rotterdam, Erasmus MC, Intellectual Disabil Med, Dept Gen Practice, Rotterdam, Netherlands.
   [Valentin, B.; Schoufour, J.] Amsterdam Univ Appl Sci, Ctr Expertise Urban Vital, Fac Sports & Nutr, Fac Hlth, Amsterdam, Netherlands.
   [Valentin, B.] Univ Med Ctr, Erasmus MC, Intellectual Disabil Med, Dept Gen Practice, Gravendijkwal 230, NL-3015 CE Rotterdam, Netherlands.
C3 Erasmus University Rotterdam; Erasmus MC; Erasmus University Rotterdam;
   Erasmus MC
RP Valentin, B (corresponding author), Univ Med Ctr, Erasmus MC, Intellectual Disabil Med, Dept Gen Practice, Gravendijkwal 230, NL-3015 CE Rotterdam, Netherlands.
EM b.valentin@hva.nl
RI Maes-Festen, Dederieke/P-8654-2016; Oppewal, Alyt/AFN-7707-2022
OI Valentin, Bas/0000-0001-9031-3630; Oppewal, Alyt/0000-0001-6630-8807
FU Netherlands Organization for Health Research and Development (ZonMw)
   [57,000,003, 314,030,302]
FX This study was carried out with the financial supportof the
   participating care organisations and the Netherlands Organization for
   Health Research and Development (ZonMw, No. 57,000,003 and No.
   314,030,302). The sponsors had no further role in the study.
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NR 57
TC 1
Z9 1
U1 1
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0964-2633
EI 1365-2788
J9 J INTELL DISABIL RES
JI J. Intell. Disabil. Res.
PD NOV
PY 2023
VL 67
IS 11
BP 1161
EP 1173
DI 10.1111/jir.13078
EA AUG 2023
PG 13
WC Education, Special; Genetics & Heredity; Clinical Neurology; Psychiatry;
   Rehabilitation
WE Social Science Citation Index (SSCI)
SC Education & Educational Research; Genetics & Heredity; Neurosciences &
   Neurology; Psychiatry; Rehabilitation
GA HI0Z9
UT WOS:001052325300001
PM 37608512
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Jin, MY
   Zhang, Z
   Li, YZ
   Teng, D
   Shi, XG
   Ba, JM
   Chen, B
   Du, JL
   He, LJ
   Lai, XY
   Teng, XC
   Li, YB
   Chi, HY
   Liao, EY
   Liu, C
   Liu, LB
   Qin, GJ
   Qin, YF
   Quan, HB
   Shi, BY
   Sun, H
   Tang, XL
   Tong, NW
   Wang, GX
   Zhang, JA
   Wang, YM
   Xue, YM
   Yan, L
   Yang, J
   Yang, LH
   Yao, YL
   Ye, Z
   Zhang, Q
   Zhang, LH
   Zhu, J
   Zhu, M
   Ning, G
   Mu, YM
   Zhao, JJ
   Teng, WP
   Shan, ZY
AF Jin, Mingyue
   Zhang, Zhuo
   Li, Yongze
   Teng, Di
   Shi, Xiaoguang
   Ba, Jianming
   Chen, Bing
   Du, Jianling
   He, Lanjie
   Lai, Xiaoyang
   Teng, Xiaochun
   Li, Yanbo
   Chi, Haiyi
   Liao, Eryuan
   Liu, Chao
   Liu, Libin
   Qin, Guijun
   Qin, Yingfen
   Quan, Huibiao
   Shi, Bingyin
   Sun, Hui
   Tang, Xulei
   Tong, Nanwei
   Wang, Guixia
   Zhang, Jin-an
   Wang, Youmin
   Xue, Yuanming
   Yan, Li
   Yang, Jing
   Yang, Lihui
   Yao, Yongli
   Ye, Zhen
   Zhang, Qiao
   Zhang, Lihui
   Zhu, Jun
   Zhu, Mei
   Ning, Guang
   Mu, Yiming
   Zhao, Jiajun
   Teng, Weiping
   Shan, Zhongyan
TI U-Shaped Associations Between Urinary Iodine Concentration and the
   Prevalence of Metabolic Disorders: A Cross-Sectional Study
SO THYROID
LA English
DT Article
DE iodine; metabolism; metabolic disorders; epidemiology; TIDE
ID OXIDATIVE STRESS; UNITED-STATES; SALT INTAKE; ANTIOXIDANT; ADULTS;
   CHINA; AWARENESS; DISEASE; WOMEN
AB Background: Iodine is important in both thyroid function and human metabolism. Studies have explored the effect of iodine on metabolic disorders through thyroid function. This study aimed to investigate the relationship between iodine status and metabolic disorders, such as metabolic syndrome (MetS), hypertension, impaired glucose metabolism, central obesity, and dyslipidemia.
   Methods: A total of 51,795 subjects aged >= 18 years from the TIDE (Thyroid Disorders, Iodine Status and Diabetes, a national epidemiological cross-sectional study) program were included. The prevalence of metabolic disorders and its related diseases was calculated based on the level of urinary iodine concentrations (UICs) using the chi-square method. To further explore whether the prevalence was associated with UIC, quadratic and UIC-stratified logistic regression models were used.
   Results: The prevalence of metabolic disorders as a function of UIC was found to be U-shaped with a lower prevalence of 76.0% at an UIC of 300-499 mu g/L. Participants with an UIC of 300-499 mu g/L showed an association with metabolic disorders (odds ratio [OR] = 0.857, 95% confidence interval [CI 0.796-0.922]) and hypertension (OR = 0.873 [CI 0.814-0.936]). An UIC of 300-799 mu g/L was found to be associated with the occurrence of MetS and impaired glucose tolerance. An UIC of 500-799 mu g/L was associated with the occurrence of prediabetes (OR = 0.883 [CI 0.797-0.978]). An UIC of >= 300 mu g/L was associated with the occurrence of hypertriglyceridemia, hypercholesterolemia, and high levels of low-density lipoprotein cholesterol. Furthermore, an UIC of <100 mu g/L showed an association with hypertension (OR = 1.097 [CI 1.035-1.162]) and hypercholesterolemia (OR = 1.178 [CI 1.117-1.242]).
   Conclusions: The association between UICs in adults and metabolic disorders and its related diseases is U-shaped. The association between UIC and metabolic disorders disappears in cases of iodine deficiency (<100 mu g/L) or excess (>= 500 mu g/L).
C1 [Jin, Mingyue; Zhang, Zhuo; Li, Yongze; Teng, Di; Shi, Xiaoguang; Teng, Xiaochun; Teng, Weiping; Shan, Zhongyan] China Med Univ, Dept Endocrinol & Metab, Hosp 1, 155 Nanjing Bei St, Shenyang 110001, Liaoning, Peoples R China.
   [Ba, Jianming; Mu, Yiming] Chinese Peoples Liberat Army Gen Hosp, Dept Endocrinol, Beijing, Peoples R China.
   [Chen, Bing] Third Mil Med Univ, Southwest Hosp, Dept Endocrinol, Chongqing, Peoples R China.
   [Du, Jianling] Dalian Med Univ, Dept Endocrinol, Affiliated Hosp 1, Dalian, Peoples R China.
   [He, Lanjie] Ningxia Med Univ, Dept Endocrinol, Cardiovasc & Cerebrovasc Dis Hosp, Yinchuan, Ningxia, Peoples R China.
   [Lai, Xiaoyang] Nanchang Univ, Dept Endocrinol & Metab, Affiliated Hosp 2, Nanchang, Jiangxi, Peoples R China.
   [Li, Yanbo] Harbin Med Univ, Dept Endocrinol, Affiliated Hosp 1, Harbin, Peoples R China.
   [Chi, Haiyi] Hohhot First Hosp, Dept Endocrinol, Hohhot, Peoples R China.
   [Liao, Eryuan] Cent South Univ, Xiangya Hosp 2, Dept Endocrinol & Metab, Changsha, Peoples R China.
   [Liu, Chao] Nanjing Univ Chinese Med, Affiliated Hosp Integrated Tradit Chinese & Weste, Res Ctr Endocrine & Metab Dis, Nanjing, Peoples R China.
   [Liu, Libin] Fujian Med Univ, Fujian Inst Endocrinol, Dept Endocrinol & Metab, Union Hosp, Fuzhou, Peoples R China.
   [Qin, Guijun] Zhengzhou Univ, Affiliated Hosp 1, Dept Internal Med, Div Endocrinol, Zhengzhou, Peoples R China.
   [Qin, Yingfen] Guangxi Med Univ, Dept Endocrine, Affiliated Hosp 1, Nanning, Peoples R China.
   [Quan, Huibiao] Hainan Gen Hosp, Dept Endocrinol, Haikou, Hainan, Peoples R China.
   [Shi, Bingyin] Xi An Jiao Tong Univ, Dept Endocrinol, Affiliated Hosp 1, Xian, Peoples R China.
   [Sun, Hui] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Endocrinol, Wuhan, Peoples R China.
   [Tang, Xulei] Lanzhou Univ, Dept Endocrinol, Hosp 1, Lanzhou, Peoples R China.
   [Tong, Nanwei] Sichuan Univ, West China Hosp, Dept Endocrinol & Metab, State Key Lab Biotherapy, Chengdu, Peoples R China.
   [Wang, Guixia] First Hosp Jilin Univ, Dept Endocrinol & Metab, Changchun, Peoples R China.
   [Zhang, Jin-an] Shanghai Univ Med & Hlth Sci, Dept Endocrinol, Affiliated Zhoupu Hosp, Shanghai, Peoples R China.
   [Wang, Youmin] Hui Med Univ, Dept Endocrinol, Hosp 1, Hefei, Peoples R China.
   [Xue, Yuanming] First Peoples Hosp Yunnan Prov, Dept Endocrinol, Kunming, Yunnan, Peoples R China.
   [Yan, Li] Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Endocrinol & Metab, Guangzhou, Peoples R China.
   [Yang, Jing] Shanxi Med Univ, Dept Endocrinol, Hosp 1, Taiyuan, Peoples R China.
   [Yang, Lihui] Peoples Hosp Tibet Autonomous Reg, Dept Endocrinol & Metab, Lhasa, Peoples R China.
   [Yao, Yongli] Qinghai Prov Peoples Hosp, Dept Endocrinol, Xining, Peoples R China.
   [Ye, Zhen] Zhejiang Prov Ctr Dis Control & Prevent, Hangzhou, Peoples R China.
   [Zhang, Qiao] Guiyang Med Univ, Dept Endocrinol & Metab, Affiliated Hosp, Guiyang, Peoples R China.
   [Zhang, Lihui] Hebei Med Univ, Dept Endocrinol, Hosp 2, Shijiazhuang, Hebei, Peoples R China.
   [Zhu, Jun] Xinjiang Med Univ, Dept Endocrinol, Affiliated Hosp 1, Urumqi, Xinjiang, Peoples R China.
   [Zhu, Mei] Tianjin Med Univ, Dept Endocrinol & Metab, Gen Hosp, Tianjin, Peoples R China.
   [Ning, Guang] Shanghai Jiao Tong Univ, Dept Endocrinol & Metab, Rui Jin Hosp, Sch Med, Shanghai, Peoples R China.
   [Ning, Guang] Shanghai Jiao Tong Univ, Inst Endocrinol, Rui Jin Hosp, Sch Med, Shanghai, Peoples R China.
   [Zhao, Jiajun] Shandong Univ, Dept Endocrinol, Shandong Prov Hosp, Jinan, Peoples R China.
C3 China Medical University; Chinese People's Liberation Army General
   Hospital; Army Medical University; Dalian Medical University; Ningxia
   Medical University; Nanchang University; Harbin Medical University;
   Central South University; Nanjing University of Chinese Medicine; Fujian
   Medical University; Zhengzhou University; Guangxi Medical University;
   Hainan Medical University; Xi'an Jiaotong University; Huazhong
   University of Science & Technology; Lanzhou University; Sichuan
   University; Jilin University; Shanghai University of Medicine & Health
   Sciences; Kunming University of Science & Technology; Sun Yat Sen
   University; Shanxi Medical University; Zhejiang Provincial Center for
   Disease Control & Prevention; Guizhou Medical University; Hebei Medical
   University; Xinjiang Medical University; Tianjin Medical University;
   Shanghai Jiao Tong University; Shanghai Jiao Tong University; Shandong
   University; Shandong First Medical University & Shandong Academy of
   Medical Sciences
RP Shan, ZY (corresponding author), China Med Univ, Dept Endocrinol & Metab, Hosp 1, 155 Nanjing Bei St, Shenyang 110001, Liaoning, Peoples R China.; Teng, WP (corresponding author), China Med Univ, Hosp 1, Inst Endocrinol, 155 Nanjing Bei St, Shenyang 110001, Peoples R China.
EM twp@vip.163.com; cmushanzhongyan@163.com
RI yin, yue/JQV-9753-2023; YE, Zhen/IYS-1774-2023; Zhao,
   Jiajun/W-2963-2018; Liu, Libin/ABH-6019-2020; Lai, Xiaoyang/L-5445-2019;
   Martinez, Ramfis/I-7205-2019; Zhiyun, Zhao/ABH-9036-2020
OI LI, YONGZE/0000-0001-8782-3314; Zhao, Jiajun/0000-0003-3267-9292; LIU,
   CHAO/0000-0002-3643-3903
FU Research Fund for Public Welfare from the National Health and Family
   Planning Commission of China [201402005]; Scientific Bolstering Project
   of Sichuan Province [2014SZ0005]
FX This work was supported by the Research Fund for Public Welfare from the
   National Health and Family Planning Commission of China (Grant No.
   201402005). Scientific Bolstering Project of Sichuan Province (Grant No.
   2014SZ0005).
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NR 33
TC 31
Z9 33
U1 0
U2 30
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1050-7256
EI 1557-9077
J9 THYROID
JI Thyroid
PD JUL 1
PY 2020
VL 30
IS 7
BP 1053
EP 1065
DI 10.1089/thy.2019.0516
EA APR 2020
PG 13
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA MN5DH
UT WOS:000529522300001
PM 32188373
DA 2025-06-11
ER

PT J
AU Larzul, C
   Terenina, E
   Foury, A
   Billon, Y
   Louveau, I
   Merlot, E
   Mormede, P
AF Larzul, C.
   Terenina, E.
   Foury, A.
   Billon, Y.
   Louveau, I.
   Merlot, E.
   Mormede, P.
TI The cortisol response to ACTH in pigs, heritability and influence of
   corticosteroid-binding globulin
SO ANIMAL
LA English
DT Article
DE ACTH stimulation test; cortisol; CBG; robustness; pig
ID PITUITARY-ADRENAL AXIS; LARGE-WHITE; MOLECULAR-GENETICS; MEAT QUALITY;
   STRESS; GROWTH; LINES; GLUCOCORTICOIDS; PERFORMANCE; METABOLISM
AB In the search for biological basis of robustness, this study aimed (i) at the determination of the heritability of the cortisol response to ACTH in juvenile pigs, using restricted maximum likelihood methodology applied to a multiple trait animal model, and (ii) at the study of the relationships between basal and stimulated cortisol levels with corticosteroid-binding globulin (CBG), IGF-I and haptoglobin, all important players in glucose metabolism and production traits. At 6 weeks of age, 298 intact male and female piglets from 30 litters (30 dams and 30 boars) were injected with 250 jug ACTH(1-24) (Synacthen). Blood was taken before ACTH injection to measure basal levels of cortisol, glucose, CBG, IGF-I and haptoglobin, and 60 min later to measure stimulated cortisol levels and glucose. Cortisol increased 2.8-fold after ACTH injection, with a high correlation between basal and stimulated levels (phenotypic correlation, r(p) = 0.539; genetic correlation, r(g) = 0.938). Post-ACTH cortisol levels were highly heritable (h(2) = 0.684) and could therefore be used for genetic selection of animals with a more reactive hypothalamic pituitary adrenocortical axis. CBG binding capacity correlated with cortisol levels measured in basal conditions in males only. No correlation was found between CBG binding capacity and post-ACTH cortisol levels. Basal IGF-I concentration was positively correlated with BW at birth and weaning, and showed a high correlation with CBG binding capacity with a strong sexual dimorphism, the correlation being much higher in males than in females. Basal haptoglobin concentrations were negatively correlated with CBG binding capacity and IGF-I concentrations. Complex relationships were also found between circulating glucose levels and these different variables that have been shown to be related to glucose resistance in humans. These data are therefore valuable for the genetic selection of animals to explore the consequences on production and robustness traits, but also point at pigs as a relevant model to explore the underlying mechanisms of the metabolic syndrome including the contribution of genetic factors.
C1 [Larzul, C.] GABI, INRA, F-78352 Jouy En Josas, France.
   [Larzul, C.; Terenina, E.; Mormede, P.] Genet Physiol & Syst Elevage GenPhySE, INRA, F-31326 Castanet Tolosan, France.
   [Larzul, C.; Terenina, E.; Mormede, P.] Univ Toulouse, Genet Physiol & Syst Elevage GenPhySE, ENSAT, INP, F-31326 Castanet Tolosan, France.
   [Larzul, C.; Terenina, E.; Mormede, P.] Univ Toulouse, Genet Physiol & Syst Elevage GenPhySE, ENVT, INP, F-31076 Toulouse, France.
   [Foury, A.] Nutr & Neurobiol Integree NutriNeuro, INRA, F-33076 Bordeaux, France.
   [Billon, Y.] Genet Experimentat & Syst Innovants GenESI, INRA, F-17700 St Pierre Damilly, France.
   [Louveau, I.; Merlot, E.] PEGASE, INRA, UMR1348, F-35590 St Gilles, France.
   [Louveau, I.; Merlot, E.] PEGASE, Agrocampus Ouest, UMR1348, F-35000 Rennes, France.
C3 AgroParisTech; Universite Paris Saclay; INRAE; INRAE; Centre National de
   la Recherche Scientifique (CNRS); CNRS - Institute of Physics (INP);
   Universite Federale Toulouse Midi-Pyrenees (ComUE); Universite de
   Toulouse; Institut National Polytechnique de Toulouse; Universite de
   Toulouse; Ecole Nationale Veterinaire de Toulouse; Universite Federale
   Toulouse Midi-Pyrenees (ComUE); Institut National Polytechnique de
   Toulouse; Centre National de la Recherche Scientifique (CNRS); CNRS -
   Institute of Physics (INP); INRAE; INRAE; INRAE; Institut Agro;
   Agrocampus Ouest
RP Larzul, C (corresponding author), GABI, INRA, F-78352 Jouy En Josas, France.
EM Pierre.Mormede@toulouse.inra.fr
RI Larzul, Catherine/AAX-8677-2020; Merlot, Elodie/AAQ-8761-2020; Mormede,
   Pierre/N-3918-2019; yvon, Billon/HOH-7578-2023; Mormede,
   Pierre/K-5537-2015
OI Foury, Aline/0000-0002-4552-3222; Merlot, Elodie/0000-0003-2300-0970;
   Mormede, Pierre/0000-0003-0345-1432; Terenina,
   Elena/0009-0005-1398-4525; Larzul, Catherine/0000-0002-0533-331X
FU INRA; Animal Genetics Division
FX The authors wish to thank C. Trefeu and F. Thomas for their expert
   technical assistance in IGF-I and haptoglobin assays, and M.-P. Moisan
   for her comments on a previous version of the manuscript. This work was
   supported by INRA, including a special grant from the Animal Genetics
   Division.
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NR 45
TC 24
Z9 26
U1 0
U2 36
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1751-7311
EI 1751-732X
J9 ANIMAL
JI Animal
PD DEC
PY 2015
VL 9
IS 12
BP 1929
EP 1934
DI 10.1017/S1751731115001767
PG 6
WC Agriculture, Dairy & Animal Science; Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture; Veterinary Sciences
GA CX2GG
UT WOS:000365514200002
PM 26302113
OA hybrid, Green Submitted
DA 2025-06-11
ER

PT J
AU Zhou, MS
   Liu, C
   Tian, RX
   Nishiyama, A
   Raij, L
AF Zhou, Ming-Sheng
   Liu, Chang
   Tian, Runxia
   Nishiyama, Akira
   Raij, Leopoldo
TI Skeletal muscle insulin resistance in salt-sensitive hypertension: role
   of angiotensin II activation of NFκB
SO CARDIOVASCULAR DIABETOLOGY
LA English
DT Article
DE Angiotensin II; Hypertension; Insulin resistance; NF kappa B; Skeletal
   muscle
ID OXIDATIVE STRESS; RECEPTOR BLOCKERS; CARDIOVASCULAR-DISEASE; ALDOSTERONE
   SYSTEM; METABOLIC SYNDROME; DIABETES-MELLITUS; BLOOD-PRESSURE; NADPH
   OXIDASE; NITRIC-OXIDE; IKK-BETA
AB Background: We have previously shown that in hypertensive Dahl salt-sensitive (DS) rats, impaired endothelium-dependent relaxation to acetylcholine and to insulin is mechanistically linked to up-regulation of angiotensin (Ang) II actions and the production of reactive oxygen species (ROS) and to activation of the proinflammatory transcription factor (NF)kappa B. Here we investigated whether Ang II activation of NF kappa B contributed to insulin resistance in the skeletal muscle of this animal model.
   Methods: DS rats were fed either a normal (NS, 0.5% NaCl) or high (HS, 4% NaCl) salt diet for 6 weeks. In addition, 3 separate groups of HS rats were given angiotensin receptor 1 blocker candesartan (ARB, 10 mg/kg/day in drinking water), antioxidant tempol (1 mmol/L in drinking water) or NF kappa B inhibitor PDTC (150 mg/kg in drinking water).
   Results: DS rats manifested an increase in soleus muscle Ang II content, ROS production and phosopho-I kappa Ba/I kappa Ba ratio, ARB or tempol reduced ROS and phospho-I kappa Ba/I kappa Ba ratio. Hypertensive DS rats also manifested a reduction in glucose infusion rate, impaired insulin-induced Akt phosphorylation and Glut-4 translocation in the soleus muscle, which were prevented with treatment of either ARB, tempol, or PDTC. Data from the rat diabetes signaling pathway PCR array showed that 8 genes among 84 target genes were altered in the muscle of hypertensive rats with the increase in gene expression of ACE1 and 5 proinflammatory genes, and decrease of 2 glucose metabolic genes. Incubation of the muscle with NF kappa B SN50 (a specific peptide inhibitor of NF kappa B) ex vivo reversed changes in hypertension-induced gene expression.
   Conclusion: The current findings strongly suggest that the activation of NF kappa B inflammatory pathway by Ang II play a critical role in skeletal muscle insulin resistance in salt-sensitive hypertension.
C1 [Zhou, Ming-Sheng] Liaoning Med Univ, Dept Physiol, Jinzhou, Peoples R China.
   [Liu, Chang] Liaoning Med Univ, Dept Endocrinol, Jinzhou, Peoples R China.
   [Zhou, Ming-Sheng; Tian, Runxia; Raij, Leopoldo] Miami VA Med Ctr, Hypertens Nephrol Sect, Miami, FL USA.
   [Nishiyama, Akira] Kagawa Univ, Sch Med, Dept Pharmacol, Kagawa, Japan.
   [Raij, Leopoldo] Univ Miami, Miller Sch Med, Hypertens Nephrol Sect, Vasc Biol Inst, Miami, FL 33136 USA.
C3 Jinzhou Medical University; Jinzhou Medical University; Kagawa
   University; University of Miami
RP Zhou, MS (corresponding author), Liaoning Med Univ, Dept Physiol, Jinzhou, Peoples R China.
EM zhoums1963@163.com
OI Nishiyama, Akira/0000-0001-5971-820X
FU National Natural Science Foundation of China [81470532]; American Heart
   Association National Scientist Development Award; South Florida Veterans
   Affairs Foundation for Research and Education
FX This work was supported by the grant from the National Natural Science
   Foundation of China (No. 81470532) and American Heart Association
   National Scientist Development Award to Ming-Sheng Zhou, and by funds
   from the South Florida Veterans Affairs Foundation for Research and
   Education to Leopoldo Raij.
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NR 48
TC 30
Z9 31
U1 0
U2 21
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1475-2840
J9 CARDIOVASC DIABETOL
JI Cardiovasc. Diabetol.
PD MAY 1
PY 2015
VL 14
AR 45
DI 10.1186/s12933-015-0211-6
PG 9
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism
GA CH3SC
UT WOS:000353949600001
PM 25928697
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Park, JY
   Paik, JK
   Kim, OY
   Chae, JS
   Jang, Y
   Lee, JH
AF Park, Ju Yeon
   Paik, Jean Kyung
   Kim, Oh Yoen
   Chae, Jey Sook
   Jang, Yangsoo
   Lee, Jong Ho
TI Interactions between the APOA5-1131T&gt;C and the FEN1
   10154G&gt;T polymorphisms on ω6 polyunsaturated fatty acids in serum
   phospholipids and coronary artery disease
SO JOURNAL OF LIPID RESEARCH
LA English
DT Article
DE arachidonic acid; linoleic acid; CAD risk; apolipoprotein A5
ID APOLIPOPROTEIN-A-V; TRIGLYCERIDE-RICH LIPOPROTEINS; ACUTE
   MYOCARDIAL-INFARCTION; METABOLIC SYNDROME; ARACHIDONIC-ACID; OXIDATIVE
   STRESS; ADIPOSE-TISSUE; DIETARY-FAT; PARTICLE-SIZE; HEART-DISEASE
AB We determined the contribution of the combination of FEN1 10154G>T with the most significant association in the analysis of plasma arachidonic acid (AA, 20:4 omega 6) and the APOA5-1131T>C on phospholipid omega 6PUFA and coronary artery disease (CAD). Patients with CAD (n = 807, 27-81 years of age) and healthy controls (n = 1123) were genotyped for FEN1 10154G>T and APOA5-1131T>C. We found a significant interaction between these two genes for CAD risk (P = 0.007) adjusted for confounding factors. APOA5-1131C allele carriers had a higher CAD risk [ odds ratio (OR): 1.484, 95% confidence interval (CI): 1.31-1.96; P = 0.005] compared with APOA5-1131TT individuals in the FEN1 10154GG genotype group but not in the FEN1 10154T allele group (OR: 1.096, 95% CI:0.84-1.43; P = 0.504). Significant interactions between these two genes were also observed for the AA proportion (P = 0.04) and the ratio of AA/linoleic acid (LA, 18:2 omega 6) (P = 0.004) in serum phospholipids of controls. The APOA5-1131C allele was associated with lower AA (P = 0.027) and AA/LA (P = 0.014) only in controls carrying the FEN1 10154T allele. In conclusion, the interaction between these genes suggests that the FEN1 10154T variant allele decreases AA and AA/LA in the serum phospholipids of carriers of the APOA5-1131C allele, but contributes no significant increase in CAD risk for this population subset despite their increased triglylcerides and decreased apoA5.-Park, J. Y., J. K. Paik, O. Y. Kim, J. S. Chae, Y. Jang, and J. H. Lee. Interactions between the APOA5-1131T>C and the FEN1 10154G>T polymorphisms on omega 6 polyunsaturated fatty acids in serum phospholipids and coronary artery disease. J. Lipid Res. 2010. 51: 3281-3288.
C1 [Park, Ju Yeon; Paik, Jean Kyung; Kim, Oh Yoen; Chae, Jey Sook; Lee, Jong Ho] Yonsei Univ, Coll Human Ecol, Natl Res Lab Clin Nutrigenet Nutrigenom, Dept Food & Nutr, Seoul 120749, South Korea.
   [Park, Ju Yeon; Lee, Jong Ho] Yonsei Univ, Coll Human Ecol, Dept Food & Nutr, Project BK21, Seoul 120749, South Korea.
   [Paik, Jean Kyung; Kim, Oh Yoen; Chae, Jey Sook; Jang, Yangsoo; Lee, Jong Ho] Yonsei Univ, Yonsei Univ Res Inst Sci Aging, Seoul 120749, South Korea.
   [Jang, Yangsoo] Yonsei Univ, Coll Med, Div Cardiol, Cardiovasc Genome Ctr, Seoul, South Korea.
   [Jang, Yangsoo] Yonsei Univ, Coll Med, Severance Med Res Inst, Seoul, South Korea.
   [Jang, Yangsoo] Yonsei Univ, Coll Med, Severance Biomed Sci Res Inst, Seoul, South Korea.
C3 Yonsei University; Yonsei University; Yonsei University; Yonsei
   University; Yonsei University Health System; Yonsei University; Yonsei
   University Health System; Yonsei University; Yonsei University Health
   System
RP Lee, JH (corresponding author), Yonsei Univ, Coll Human Ecol, Natl Res Lab Clin Nutrigenet Nutrigenom, Dept Food & Nutr, Seoul 120749, South Korea.
EM jhleeb@yonsei.ac.kr
RI Park, Ju-Yeon/MYR-6366-2025; Jang, Yang/D-4803-2012; Kim,
   Oh/AAA-6492-2022
OI Jang, Yangsoo/0000-0002-2169-3112
FU National Research Foundation, Ministry of Education, Science and
   Technology, Seoul, Korea [2010-0015017, M10642120002-06N4212-00210,
   C00048]; Ministry of Health & Welfare, Seoul, Korea [A000385]
FX This work was supported by the National Research Foundation, Ministry of
   Education, Science and Technology (Mid-career Researcher Program:
   2010-0015017, M10642120002-06N4212-00210 and C00048), Seoul, Korea, and
   Korea Health 21 R&D Projects, Ministry of Health & Welfare (A000385),
   Seoul, Korea. None of the authors have any conflicts of interest in
   relation to the materials presented in this paper.
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NR 43
TC 12
Z9 13
U1 0
U2 3
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0022-2275
EI 1539-7262
J9 J LIPID RES
JI J. Lipid Res.
PD NOV
PY 2010
VL 51
IS 11
BP 3281
EP 3288
DI 10.1194/jlr.M010330
PG 8
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 662LG
UT WOS:000282808200020
PM 20802161
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Vitaglione, P
   Morisco, F
   Mazzone, G
   Amoruso, DC
   Ribecco, MT
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   Fogliano, V
   Caporaso, N
   D'Argenio, G
AF Vitaglione, Paola
   Morisco, Filomena
   Mazzone, Giovanna
   Amoruso, Daniela Caterina
   Ribecco, Maria Teresa
   Romano, Antonietta
   Fogliano, Vincenzo
   Caporaso, Nicola
   D'Argenio, Giuseppe
TI Coffee Reduces Liver Damage in a Rat Model of Steatohepatitis: The
   Underlying Mechanisms and the Role of Polyphenols and Melanoidins
SO HEPATOLOGY
LA English
DT Article
ID GAMMA-GLUTAMYL-TRANSFERASE; NF-KAPPA-B; NONALCOHOLIC STEATOHEPATITIS;
   HEPATOCELLULAR-CARCINOMA; METABOLIC SYNDROME; HEPATIC STEATOSIS; TEA
   CONSUMPTION; UNITED-STATES; RISK; DISEASE
AB Epidemiological data associate coffee consumption with a lower prevalence of chronic liver disease and a reduced risk of elevated liver enzyme levels (gamma glutamyl transpeptidase and alanine aminotransferase), advanced liver disease and its complications, and hepatocellular carcinoma. Knowledge of the mechanisms underlying these effects and the coffee components responsible for these properties is still lacking. In this study, 1.5 mL/day of decaffeinated coffee or its polyphenols or melanoidins (corresponding to approximately 2 cups of filtered coffee or 6 cups of espresso coffee for a 70-kg person) were added for 8 weeks to the drinking water of rats who were being fed a high-fat, high-calorie solid diet (HFD) for the previous 4 weeks. At week 12, HFD + water rats showed a clinical picture typical of advanced nonalcoholic steatohepatitis compared with control rats (normal diet + water). In comparison, HFD + coffee rats showed: (1) reduced hepatic fat and collagen, as well as reduced serum alanine aminotransferase and triglycerides; (2) a two-fold reduced/oxidized glutathione ratio in both serum and liver; (3) reduced serum malondialdehyde (lipid peroxidation) and increased ferric reducing antioxidant power (reducing activity); (4) reduced expression of tumor necrosis factor alpha (TNF-alpha), tissue transglutaminase, and transforming growth factor beta and increased expression of adiponectin receptor and peroxisome proliferator-activated receptor alpha in liver tissue; and (5) reduced hepatic concentrations of proinflammatory TNF-alpha and interferon-gamma and increased anti-inflammatory interleukin-4 and interleukin-10. Conclusion: Our data demonstrate that coffee consumption protects the liver from damage caused by a high-fat diet. This effect was mediated by a reduction in hepatic fat accumulation (through increased fatty acid beta-oxidation); systemic and liver oxidative stress (through the glutathione system); liver inflammation (through modulation of genes); and expression and concentrations of proteins and cytokines related to inflammation. (HEPATOLOGY 2010;52:1652-1661)
C1 [Vitaglione, Paola; Morisco, Filomena; Fogliano, Vincenzo] Univ Napoli Federico II, Dept Food Sci, I-80055 Portici, Italy.
   [Mazzone, Giovanna; Amoruso, Daniela Caterina; Ribecco, Maria Teresa; Romano, Antonietta; Caporaso, Nicola; D'Argenio, Giuseppe] Univ Napoli Federico II, Gastroenterol Unit, Dept Clin & Expt Med, I-80055 Naples, Italy.
C3 University of Naples Federico II; University of Naples Federico II
RP Vitaglione, P (corresponding author), Univ Napoli Federico II, Dept Food Sci, Via Univ 100,Pco Gussone Ed 84, I-80055 Portici, Italy.
EM paola.vitaglione@unina.it
RI caporaso, nicola/F-6502-2012; Morisco, Filomena/AHI-0851-2022; fogliano,
   vincenzo/A-1419-2009; Vitaglione, Paola/B-2864-2010; Romano,
   Antonietta/K-4060-2018
OI fogliano, vincenzo/0000-0001-8786-9355; Ribecco, Maria Teresa
   Silvia/0000-0003-3278-9221; Vitaglione, Paola/0000-0002-6608-5209;
   morisco, filomena/0000-0002-9059-8311; Romano,
   Antonietta/0000-0001-7391-0038; Morisco, Filomena/0009-0006-1537-5034
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NR 29
TC 179
Z9 186
U1 3
U2 47
PU JOHN WILEY & SONS INC
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 0270-9139
J9 HEPATOLOGY
JI Hepatology
PD NOV
PY 2010
VL 52
IS 5
BP 1652
EP 1661
DI 10.1002/hep.23902
PG 10
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 674RH
UT WOS:000283764800015
PM 21038411
DA 2025-06-11
ER

PT J
AU Sherman, CB
   Peterson, SJ
   Frishman, WH
AF Sherman, Courtney B.
   Peterson, Stephen J.
   Frishman, William H.
TI Apolipoprotein A-I Mimetic Peptides A Potential New Therapy for the
   Prevention of Atherosclerosis
SO CARDIOLOGY IN REVIEW
LA English
DT Review
DE apolipoprotein A-I mimetic peptides; 4F; atherosclerosis
ID HIGH-DENSITY-LIPOPROTEIN; ESTER TRANSFER PROTEIN; LDL RECEPTOR-NULL;
   CORONARY-HEART-DISEASE; WESTERN DIET; OXIDIZED PHOSPHOLIPIDS;
   CHOLESTEROL TRANSPORT; HEME OXYGENASE-1; OBESE MICE; INHIBITS 3
AB The beneficial effects of high-density lipoprotein (HDL) on atherosclerosis have largely been attributed to its major protein, apolipoprotein A-I (apoA-I). Used as a therapeutic intervention, apoA-I is a large protein that requires venous administration, and is both difficult and expensive to manufacture. Because of these problems with apoA-I, the generation of smaller, easier to manufacture apoA-I mimetic peptides has become a target for pharmacologic development in the therapeutic management of human atherosclerosis. A potent apoA-I mimetic peptide, 4F, was found to have significant activity in various inflammatory states in both mice and monkeys. The anti-inflammatory and antiatherogenic effects of 4F include increased pre-beta HDL formation, increased cholesterol efflux, the conversion of pro-inflammatory HDL to anti-inflammatory HDL, and reduced lipoprotein oxidation. In addition, improved arterial vasoreactivity is another important function of 4F. In a rat model of diabetes, D-4F increased arterial concentrations of heme oxygenase-1 (HO-1) and superoxide dismutase, decreased superoxide levels, reduced levels of circulating endothelial cells, decreased endothelial cell fragmentation, and restored arterial vasoreactivity to normal. In a mouse model of systemic sclerosis, D-4F functioned to improve vasodilation and angiogenic potential, while reducing myocardial inflammation and oxidative stress. With respect to mouse models of heart transplant-associated atherosclerosis, D-4F induced HO-1. In addition, D-4F was shown to improve cognitive performance in low-density lipoprotein-receptor null mice with Western diet-induced cognitive decline. D-4F also reduced the kidney content of oxidized phospholipids in a mouse model of hyperlipidemia-induced renal inflammation. In early human studies in patients with significant cardiovascular risk, a single dose of oral D-4F was found to safely improve the anti-inflammatory index of HDL. L-4F is also being studied in clinical trials as a potential treatment modality for obesity and the metabolic syndrome.
C1 [Peterson, Stephen J.; Frishman, William H.] New York Med Coll, Dept Med, Westchester Med Ctr, Valhalla, NY 10595 USA.
   [Peterson, Stephen J.; Frishman, William H.] New York Med Coll, Dept Pharmacol, Westchester Med Ctr, Valhalla, NY 10595 USA.
   [Sherman, Courtney B.] Univ Calif San Francisco, Dept Med, San Francisco, CA USA.
C3 Westchester Medical Center; New York Medical College; Westchester
   Medical Center; New York Medical College; University of California
   System; University of California San Francisco
RP Frishman, WH (corresponding author), New York Med Coll, Dept Med, Westchester Med Ctr, Munger 263, Valhalla, NY 10595 USA.
EM william_frishman@nymc.edu
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NR 59
TC 84
Z9 94
U1 1
U2 9
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1061-5377
EI 1538-4683
J9 CARDIOL REV
JI Cardiol. Rev.
PD MAY-JUN
PY 2010
VL 18
IS 3
BP 141
EP 147
DI 10.1097/CRD.0b013e3181c4b508
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 585PF
UT WOS:000276837900005
PM 20395699
DA 2025-06-11
ER

PT J
AU Yin, RX
   Wu, JZ
   Pan, SL
   Lin, WX
   Yang, DZ
   Chen, YM
AF Yin Ruixing
   Wu Jinzhen
   Pan Shangling
   Lin Weixiong
   Yang Dezhai
   Chen Yuming
TI Sex differences in environmental and genetic factors for hypertension
SO AMERICAN JOURNAL OF MEDICINE
LA English
DT Article
DE blood pressure; environmental factors; genetic factors; hypertension;
   polymorphism; sex difference
ID AMBULATORY BLOOD-PRESSURE; AT1-TYPE ANGIOTENSIN RECEPTOR;
   LIPOPROTEIN-LIPASE GENE; METABOLIC SYNDROME; OXIDATIVE STRESS; ALCOHOL
   INTAKE; FOLLOW-UP; PREVALENCE; RISK; ASSOCIATION
AB BACKGROUND: Sex differences are observed in many aspects of mammalian cardiovascular function and pathology. Hypertension is more common in men than in women of the same age. Although the effects of gonadal hormones on blood pressure are considered contributing factors, the reasons for sex differences in hypertension are still not fully understood. The present study was undertaken to compare the differences in several environmental and genetic factors beween men and women in the Hei Yi Zhuang, an isolated subgroup of the Zhuang minority in China.
   METHODS: Information on demography, diet, and lifestyle was collected in 835 women and 834 men aged 15 to 84 years. Genotyping of angiotensin-converting enzyme, adrenergic receptor beta(3), aldehyde dehydrogenase 2, calpastatin, connexin 37, hepatic lipase, lipoprotein lipase, peroxisome proliferator-activated receptor gamma, thyrotropin-releasing hormone receptor, and von Willebrand factor also was performed in these subjects.
   RESULTS: The levels of systolic and diastolic blood pressure, and the prevalence, awareness, and treatment of hypertension were lower in women than in men (P < .05). Hypertension was positively associated with age, physical activity, alcohol consumption, body mass index, waist circumference, hyperlipidemia, total energy, total fat, sodium intake, and sodium/potassium ratio, and negatively associated with education level, total dietary fiber, potassium intake, angiotensin-converting enzyme, aldehyde dehydrogenase 2, and hepatic lipase genotypes in men (P < .05). Hypertension was positively associated with age, hyperlipidemia, total energy, total fat, sodium intake, sodium/potassium ratio, calpastatin, and von Willebrand factor genotypes, and negatively associated with education level, total dietary fiber, potassium, calcium intake, lipoprotein lipase, and thyrotropin-releasing hormone receptor genotypes in women (P < .05).
   CONCLUSION: Sex differences in the prevalence of hypertension in the Hei Yi Zhuang population may be mainly attributed to the differences in dietary habits, lifestyle choices, sodium and potassium intakes, physical activity level, and some genetic polymorphisms. (C) 2008 Elsevier Inc. All rights reserved.
C1 [Yin Ruixing; Wu Jinzhen; Chen Yuming] Guangxi Med Univ, Inst Cardiovasc Dis, Dept Cardiol, Affiliated Hosp 1, Nanning 530021, Guangxi, Peoples R China.
   [Pan Shangling] Guangxi Med Univ, Sch Premed Sci, Dept Pathophysiol, Nanning 530021, Guangxi, Peoples R China.
   [Lin Weixiong; Yang Dezhai] Guangxi Med Univ, Med Sci Res Ctr, Dept Mol Biol, Nanning 530021, Guangxi, Peoples R China.
C3 Guangxi Medical University; Guangxi Medical University; Guangxi Medical
   University
RP Yin, RX (corresponding author), Guangxi Med Univ, Inst Cardiovasc Dis, Dept Cardiol, 22 Shuangyong Rd, Nanning 530021, Guangxi, Peoples R China.
EM yinruixing@yahoo.com.cn
RI Pan, Shang-Ling/G-9581-2016
FU National Natural Science Foundation of China [30360038]
FX This study was supported by the National Natural Science Foundation of
   China (No. 30360038).
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NR 45
TC 32
Z9 39
U1 0
U2 21
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0002-9343
EI 1555-7162
J9 AM J MED
JI Am. J. Med.
PD SEP
PY 2008
VL 121
IS 9
BP 811
EP 819
DI 10.1016/j.amjmed.2008.04.026
PG 9
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 347UC
UT WOS:000259165600016
PM 18724972
DA 2025-06-11
ER

PT J
AU Marciniak, M
   Sato, M
   Rutkowski, R
   Zawada, A
   Juchacz, A
   Mahadea, D
   Grzymislawski, M
   Dobrowolska, A
   Kawka, E
   Korybalska, K
   Breborowicz, A
   Witowski, J
   Kanikowska, D
AF Marciniak, Martyna
   Sato, Maki
   Rutkowski, Rafal
   Zawada, Agnieszka
   Juchacz, Aldona
   Mahadea, Dagmara
   Grzymislawski, Marian
   Dobrowolska, Agnieszka
   Kawka, Edyta
   Korybalska, Katarzyna
   Breborowicz, Andrzej
   Witowski, Janusz
   Kanikowska, Dominika
TI Effect of the one-day fasting on cortisol and DHEA daily rhythm
   regarding sex, chronotype, and age among obese adults
SO FRONTIERS IN NUTRITION
LA English
DT Article
DE cortisol; DHEA; fasting; obesity; rhythm
ID PITUITARY-ADRENAL AXIS; DEHYDROEPIANDROSTERONE-SULFATE LEVELS;
   WEIGHT-LOSS; CIRCADIAN-RHYTHM; ORAL-CONTRACEPTIVES; SALIVARY CORTISOL;
   METABOLIC SYNDROME; PLASMA-CORTISOL; STRESS; WOMEN
AB IntroductionPhysiological and biochemical processes in the human body occur in a specific order and show rhythmic variability. Time dependence characterizes the secretion of cortisol and dehydroepiandrosterone (DHEA). One-day fasting implies alternating fasting days and eating days. The study aimed to determine how 24-h fasting affects the daily rhythm of cortisol and DHEA levels in obese people while taking into account gender and chronotype. MethodsForty-nine obese patients (BMI 32.2-67.1 kg/m(2); 25 women and 24 men) underwent a 3-week hospital-controlled calorie restriction diet to reduce body weight. During hospitalization, patients fasted for 1 day, during which only water could be consumed. Samples of whole mixed unstimulated saliva were collected at 2-3-h intervals over a 64-h period and analyzed for cortisol and DHEA by immunoassays. The individual chronotypes were assessed by the morning and evening questionnaire, according to Horne and ostberg. Three components of daily rhythm were evaluated: amplitude, acrophase, and the so-called MESOR. ResultsCortisol rhythm showed differences in amplitude (p = 0.0127) and acrophase (p = 0.0005). The amplitude on the fasting day was 11% higher (p = 0.224) than the day after. The acrophase advanced on the day of fasting, 48 min earlier than the day before (p = 0.0064), and by 39 min to the day after fasting (p = 0.0005). In the rhythm of DHEA, differences were found in the MESOR (p = 0.0381). The MESOR on the fasting day increased. DiscussionOur results obtained during 64 consecutive hours of saliva sampling suggest that one-day fasting may affect three components of cortisol and DHEA daily rhythm. Additionally, no differences were found in the daily rhythm between the morning and evening chronotypes and between females and males. Although aging did not influence daily cortisol rhythm, DHEA amplitude, MESOR, and acrophase changed with age. To the best of our knowledge, this is the first presentation of changes in DHEA rhythm during one-day fasting.
C1 [Marciniak, Martyna; Rutkowski, Rafal; Kawka, Edyta; Korybalska, Katarzyna; Breborowicz, Andrzej; Witowski, Janusz; Kanikowska, Dominika] Poznan Univ Med Sci, Dept Pathophysiol, Poznan, Poland.
   [Marciniak, Martyna; Zawada, Agnieszka; Mahadea, Dagmara; Grzymislawski, Marian; Dobrowolska, Agnieszka] Poznan Univ Med Sci, Dept Gastroenterol Dietet & Internal Dis, Poznan, Poland.
   [Sato, Maki] Aichi Med Univ, Inst Res, Sch Med, Nagakute, Japan.
   [Juchacz, Aldona] Greater Poland Ctr Pulmonol & Thorac Surg Eugenia, Poznan, Poland.
   [Breborowicz, Andrzej] Zielona Gora Univ, Coll Medicum, Zielona Gora, Poland.
C3 Poznan University of Medical Sciences; Poznan University of Medical
   Sciences; Aichi Medical University; University of Zielona Gora
RP Kanikowska, D (corresponding author), Poznan Univ Med Sci, Dept Pathophysiol, Poznan, Poland.
EM dkanikowska@ump.edu.pl
RI Korybalska, Katarzyna/ABG-1654-2021; Dobrowolska, Agnieszka/J-4753-2016;
   Kawka, Edyta/ABE-8097-2021; Duman, Soner/AAA-7811-2020; Kanikowska,
   Dominika/AAJ-9454-2020
OI Kawka, Edyta/0000-0002-5846-6239; Kanikowska,
   Dominika/0000-0001-8433-5745
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NR 76
TC 5
Z9 5
U1 0
U2 2
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD FEB 6
PY 2023
VL 10
AR 1078508
DI 10.3389/fnut.2023.1078508
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 9F9CJ
UT WOS:000937760100001
PM 36814510
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Mischley, LK
   Shankland, E
   Liu, SZ
   Bhayana, S
   Fox, DJ
   Marcinek, DJ
AF Mischley, Laurie K. K.
   Shankland, Eric
   Liu, Sophia Z. Z.
   Bhayana, Saakshi
   Fox, Devon J. J.
   Marcinek, David J. J.
TI ATP and NAD<SUP>+</SUP> Deficiency in Parkinson's Disease
SO NUTRIENTS
LA English
DT Article
DE neurodegenerative; bioenergetics; magnetic resonance spectroscopy;
   deficiency; metabolic perturbation; mitochondrial respiratory chain;
   complex I; NAD
ID MAGNETIC-RESONANCE-SPECTROSCOPY; SKELETAL-MUSCLE; MITOCHONDRIAL
   DYSFUNCTION; REDOX STATE; HUMAN BRAIN; CAPACITY
AB The goal of this study is to identify a signature of bioenergetic and functional markers in the muscles of individuals with Parkinson's disease (PD). Quantitative physiological properties of in vivo hand muscle (FDI, first dorsal interosseus) and leg muscle (TA, Tibialis Anterior) of older individuals with PD were compared to historical age/gender-matched controls (N = 30). Magnetic resonance spectroscopy and imaging (MRS) were used to assess in vivo mitochondrial and cell energetic dysfunction, including maximum mitochondrial ATP production (ATPmax), NAD concentrations linked to energy/stress pathways, and muscle size. Muscle function was measured via a single muscle fatigue test. TA ATPmax and NAD levels were significantly lower in the PD cohort compared to controls (ATPmax: 0.66 mM/s +/- 0.03 vs. 0.76 +/- 0.02; NAD: 0.75 mM +/- 0.05 vs. 0.91 +/- 0.04). Muscle endurance and specific force were also lower in both hand and leg muscles in the PD subjects. Exploratory analyses of mitochondrial markers and individual symptoms suggested that higher ATPmax was associated with a greater sense of motivation and engagement and less REM sleep behavior disorder (RBD). ATPmax was not associated with clinical severity or individual symptom(s), years since diagnosis, or quality of life. Results from this pilot study contribute to a growing body of evidence that PD is not a brain disease, but a systemic metabolic syndrome with disrupted cellular energetics and function in peripheral tissues. The significant impairment of both mitochondrial ATP production and resting metabolite levels in the TA muscles of the PD patients suggests that skeletal muscle mitochondrial function may be an important tool for mechanistic understanding and clinical application in PD patients. This study looked at individuals with mid-stage PD; future research should evaluate whether the observed metabolic perturbations in muscle dysfunction occur in the early stages of the disease and whether they have value as theragnostic biomarkers.
C1 [Mischley, Laurie K. K.; Shankland, Eric; Liu, Sophia Z. Z.; Bhayana, Saakshi; Marcinek, David J. J.] Univ Washington, Dept Radiol, Translat Bioenerget Lab, Seattle, WA 98105 USA.
   [Mischley, Laurie K. K.; Fox, Devon J. J.] Parkinson Ctr Pragmat Res, Seattle, WA 98133 USA.
   [Marcinek, David J. J.] Univ Washington, Dept Lab Med & Pathol, Seattle, WA 98195 USA.
C3 University of Washington; University of Washington Seattle; University
   of Washington; University of Washington Seattle
RP Marcinek, DJ (corresponding author), Univ Washington, Dept Radiol, Translat Bioenerget Lab, Seattle, WA 98105 USA.; Marcinek, DJ (corresponding author), Univ Washington, Dept Lab Med & Pathol, Seattle, WA 98195 USA.
EM dmarc@uw.edu
OI Fox, Devon J./0000-0003-1254-7065; Mischley, Laurie/0000-0003-1166-6978;
   Marcinek, David/0000-0001-5187-2149
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NR 54
TC 16
Z9 16
U1 1
U2 3
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD FEB
PY 2023
VL 15
IS 4
AR 943
DI 10.3390/nu15040943
PG 14
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 9J3CO
UT WOS:000940069500001
PM 36839301
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Sivamaruthi, BS
   Kesika, P
   Chaiyasut, C
AF Sivamaruthi, Bhagavathi Sundaram
   Kesika, Periyanaina
   Chaiyasut, Chaiyavat
TI The Influence of Supplementation of Anthocyanins on Obesity-Associated
   Comorbidities: A Concise Review
SO FOODS
LA English
DT Review
DE anthocyanins; obesity; cyanidin-3-O-beta-D-glucoside; body weight;
   chronic diseases
ID HIGH-FAT-DIET; HEPATIC LIPID-ACCUMULATION; ACTIVATED PROTEIN-KINASE;
   BODY-WEIGHT GAIN; INSULIN-RESISTANCE; OXIDATIVE STRESS; BIOACTIVE
   COMPOUNDS; METABOLIC SYNDROME; GENE-EXPRESSION; ADIPOSE-TISSUE
AB Anthocyanins are water-soluble plant pigments, and based on their chemical structure (nature, position, and the number of sugar moieties attached; the number of hydroxyl groups; acylation of sugars with acids) about 635 different anthocyanins have been identified and reported from plants. Cyanidin, peonidin, pelargonidin, petunidin, and malvidin are the commonly found anthocyanidins (aglycon forms of anthocyanins) in edible plants out of almost 25 anthocyanidins that are identified (based on the position of methoxyl and hydroxyl groups in the rings) in nature. Anthocyanins are known for numerous health benefits including anti-diabetes, anti-obesity, anti-inflammatory bowel disease, anti-cancer, etc. Obesity can be defined as excessive or abnormal adipose tissue and body mass, which increases the risk of developing chronic diseases such as diabetes, cardiovascular diseases, cancers, etc. The manuscript summarizes the recent updates in the effects of anthocyanins supplementation on the health status of obese subjects, and briefly the results of in vitro and in vivo studies. Several studies confirmed that the consumption of anthocyanins-rich food improved obesity-associated dysbiosis in gut microbiota and inflammation in adipose tissue. Anthocyanin consumption prevents obesity in healthy subjects, and aids in maintaining or reducing the body weight of obese subjects, also improving the metabolism and energy balance. Though preclinical studies proved the beneficial effects of anthocyanins such as the fact that daily intake of anthocyanin rich fruits and vegetables might aid weight maintenance in every healthy individual, Jucara pulp might control the inflammatory status of obesity, Queen garnet plum juice reduced the blood pressure and risk factors associated with metabolic disorders, and highbush organic blueberries improved the metabolism of obese individuals, we don't have an established treatment procedure to prevent or manage the over-weight condition and its comorbidities. Thus, further studies on the optimum dose, duration, and mode of supplementation of anthocyanins are required to develop an anthocyanins-based clinical procedure.
C1 [Sivamaruthi, Bhagavathi Sundaram; Kesika, Periyanaina; Chaiyasut, Chaiyavat] Chiang Mai Univ, Innovat Ctr Holist Hlth Nutraceut & Cosmeceut, Fac Pharm, Chiang Mai 50200, Thailand.
C3 Chiang Mai University
RP Sivamaruthi, BS; Chaiyasut, C (corresponding author), Chiang Mai Univ, Innovat Ctr Holist Hlth Nutraceut & Cosmeceut, Fac Pharm, Chiang Mai 50200, Thailand.
EM sivasgene@gmail.com; p.kesika@gmail.com; chaiyavat@gmail.com
RI Kesika, Periyanaina/GPK-7090-2022; Bhagavathi Sundaram,
   Sivamaruthi/S-5580-2016
OI Bhagavathi Sundaram, Sivamaruthi/0000-0002-5499-8350; Kesika,
   Periyanaina/0000-0002-3342-0947
FU Chiang Mai University
FX The authors gratefully acknowledge the Faculty of Pharmacy, and Chiang
   Mai University, Chiang Mai, Thailand. B.S.S. wish to thank Chiang Mai
   University, Post-doctoral grant for the support.
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NR 83
TC 44
Z9 46
U1 1
U2 51
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2304-8158
J9 FOODS
JI Foods
PD JUN
PY 2020
VL 9
IS 6
AR 687
DI 10.3390/foods9060687
PG 25
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA MP8XM
UT WOS:000552482200001
PM 32466434
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Huang, TF
   Tang, ZP
   Wang, S
   Hu, MW
   Zhan, L
   Yi, Y
   He, YL
   Cai, ZY
AF Huang, Ting-Fu
   Tang, Zhi-Pei
   Wang, Shan
   Hu, Ming-Wei
   Zhan, Lu
   Yi, Yi
   He, Yong-Li
   Cai, Zhi-You
TI Decrease in Serum Levels of Adiponectin and Increase in 8-OHdG: a
   Culprit for Cognitive Impairment in the Elderly Patients with Type 2
   Diabetes
SO CURRENT MOLECULAR MEDICINE
LA English
DT Article
DE Diabetes; adiponectin; 8-OhdG; cognitive impairment; oxidative stress;
   T2DM
AB Background: Adiponectin and 8-Hydroxy-2'-deoxyguanosine (8-OHdG) are identified as important biomarkers in the pathogenesis process of type 2 diabetes mellitus (T2DM). Whether adiponectin and 8-OHdG have a relation to cognitive decline in the elderly T2DM patients has been poorly understood. The aim of this study was to evaluate the effects of adiponectin and 8-OHdG in the elderly patients with T2DM and to determine the role of adiponectin and 8-OHdG in the cognitive impairment of the elderly patients with T2DM.
   Methods: 57 individuals were recruited and analyzed, with 26 cases of T2DM without cognitive impairment and 31 cases of T2DM with cognitive impairment. All of them underwent an examination of diabetes scales and blood glucose at different times. A primary diagnosis of diabetes was in line with the diagnosis criteria set by the American Diabetes Association (ADA). Statistical significance was defined as a P-value of less than 0.05.
   Results: The variables of sex, age, body mass index (BMI), hypertension, diabetes, metabolic syndrome, lacunar cerebral infarction, smoking and drinking in T2DM patients without cognitive impairment and with cognitive impairment showed no difference according to the univariate analysis exploring each variable separately (p>0.05). A significant difference was observed in the serum levels of adiponectin and 8-OHdG and the scales of MMSE and MoCA (p<0.05). Therefore, it was inferred that there is no correlation between glucose metabolic value and cognitive outcome of T2DM patients. Serum levels of adiponectin and 8-OHdG could act as biomarkers of cognitive impairment degree in the elderly T2DM patients.
   Conclusion: Serum levels of adiponectin and 8-OHdG could act as specific and sensitive biomarkers for the early diagnosis and treatment of cognitive impairment in elderly T2DM patients. Serum levels of adiponectin and 8-OHdG have a close relation to the neurological cognitive outcome of the elderly T2DM patients.
C1 [Huang, Ting-Fu; Tang, Zhi-Pei; Wang, Shan; Hu, Ming-Wei; Zhan, Lu; Yi, Yi; He, Yong-Li] Chongqing Prevent & Treatment Ctr Occupat Dis, Dept Neurol, Chongqing, Peoples R China.
   [Cai, Zhi-You] Univ Chinese Acad Sci, Chongqing Gen Hosp, Dept Neurol, 312 Zhongshan First Rd, Chongqing 400013, Peoples R China.
   [Cai, Zhi-You] Chongqing Key Lab Neurodegenerat Dis, Chongqing 400013, Peoples R China.
C3 Chinese Academy of Sciences; University of Chinese Academy of Sciences,
   CAS
RP Cai, ZY (corresponding author), Univ Chinese Acad Sci, Chongqing Gen Hosp, Dept Neurol, 312 Zhongshan First Rd, Chongqing 400013, Peoples R China.; He, YL (corresponding author), Prevent & Treatment Ctr Occupat Dis, Dept Internal Med, 301 Nancheng Rd, Chongqing 400060, Peoples R China.
EM heyongli72@163.com; caizhiyou@ucas.ac.cn
FU Chongqing Health Scientific Research Project [2017MSXM095]
FX This work was supported by grants from the Chongqing Health Scientific
   Research Project (2017MSXM095).
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NR 24
TC 12
Z9 14
U1 0
U2 10
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1566-5240
EI 1875-5666
J9 CURR MOL MED
JI Curr. Mol. Med.
PY 2020
VL 20
IS 1
BP 44
EP 50
DI 10.2174/1566524019666190819160403
PG 7
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA KC9DM
UT WOS:000507471400005
PM 31424368
DA 2025-06-11
ER

PT J
AU Krittanawong, C
   Tunhasiriwet, A
   Wang, Z
   Zhang, HJ
   Farrell, AM
   Chirapongsathorn, S
   Sun, T
   Kitai, T
   Argulian, E
AF Krittanawong, Chayakrit
   Tunhasiriwet, Anusith
   Wang, Zhen
   Zhang, HongJu
   Farrell, Ann M.
   Chirapongsathorn, Sakkarin
   Sun, Tao
   Kitai, Takeshi
   Argulian, Edgar
TI Association between short and long sleep durations and cardiovascular
   outcomes: a systematic review and meta-analysis
SO EUROPEAN HEART JOURNAL-ACUTE CARDIOVASCULAR CARE
LA English
DT Review
DE Sleep duration; cardiovascular disease; stroke; coronary heart disease;
   metabolic syndrome; type 2 diabetes; systematic review; meta-analysis
ID GLUCOSE-METABOLISM; ELEVATED GHRELIN; MORTALITY; DISEASE; RISK;
   RESTRICTION; OBESITY; LEPTIN; APNEA
AB Background: A shorter sleep duration has been identified as a risk factor for cardiovascular diseases and increased mortality. It has been hypothesized that a short sleep duration may be linked to changes in ghrelin and leptin production, leading to an alteration of stress hormone production. Here, we conducted a systematic review and meta-analysis to investigate the potential relationship between a sleep duration and cardiovascular disease mortality. Methods: We conducted a comprehensive search of Ovid Medline In-Process and other non-indexed citations, Ovid MEDLINE, Ovid Embase, Ovid Cochrane Central Register of Controlled Trials, and Scopus from database inception to March 2017. Observational studies were included if the studies reported hazard ratios or odds ratios of the associations between sleep durations (short and long) and cardiovascular disease mortality. Data were extracted by a reviewer and then reviewed by two separate reviewers. Conflicts were resolved through consensus. Using the DerSimonian and Laird random effects models, we calculated pooled hazard ratios and pooled odds ratios with 95% confidence intervals (CI). Subgroup analyses were performed to explore potential sources of heterogeneity. The quality of the included studies and publication bias were assessed. Results: In total, our meta-analysis included 19 studies (31 cohorts) with a total of 816,995 individuals with 42,870 cardiovascular disease mortality cases. In pooled analyses, both short (risk ratio 1.19; 95% CI 1.13 to 1.26, P<0.001, I-2=30.7, P-heterogeneity=0.034), and long (risk ratio 1.37; 95% CI 1.23 to 1.52, P<0.001, I-2=79.75, P-heterogeneity<0.001) sleep durations were associated with a greater risk of cardiovascular disease mortality. Conclusions: Both short (<7 hours) and long sleep durations (>9 hours) can increase the risk of overall cardiovascular disease mortality, particularly in Asian populations and elderly individuals. Future epidemiological studies would ideally include objective sleep measurements, rather than self-report measures, and all potential confounders, such as genetic variants.
C1 [Krittanawong, Chayakrit] Icahn Sch Med Mt Sinai, Dept Internal Med, 1000 10th Ave, New York, NY 10019 USA.
   [Krittanawong, Chayakrit; Argulian, Edgar] Icahn Sch Med Mt Sinai St Luke, Dept Cardiovasc Dis, Mt Sinai Heart, New York, NY USA.
   [Tunhasiriwet, Anusith; Zhang, HongJu; Sun, Tao] Mayo Clin, Div Cardiovasc Dis, Rochester, MN USA.
   [Wang, Zhen] Mayo Clin, Robert D & Patricia E Kern Ctr Sci Hlth Care Deli, Rochester, MN USA.
   [Wang, Zhen] Mayo Clin, Div Hlth Care Policy & Res, Dept Hlth Sci Res, Rochester, MN USA.
   [Farrell, Ann M.] Mayo Clin, Mayo Clin Lib, Rochester, MN USA.
   [Chirapongsathorn, Sakkarin] Mayo Clin, Div Gastroenterol & Hepatol, Rochester, MN USA.
   [Chirapongsathorn, Sakkarin] Phramongkutklao Hosp & Coll Med, Div Gastroenterol, Royal Thai Army, Bangkok, Thailand.
   [Kitai, Takeshi] Kobe City Med Ctr Gen Hosp, Dept Cardiovasc Med, Kobe, Hyogo, Japan.
   [Kitai, Takeshi] Cleveland Clin, Dept Cardiovasc Med, Cleveland, OH 44106 USA.
C3 Icahn School of Medicine at Mount Sinai; Mayo Clinic; Mayo Clinic; Mayo
   Clinic; Mayo Clinic; Mayo Clinic; Phramongkutklao Hospital;
   Phramongkutklao College of Medicine; Kobe City Medical Center General
   Hospital; Cleveland Clinic Foundation
RP Krittanawong, C (corresponding author), Icahn Sch Med Mt Sinai, Dept Internal Med, 1000 10th Ave, New York, NY 10019 USA.
EM Chayakrit.Krittanawong@Mountsinai.org
RI Sun, Tao/HKO-1723-2023
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NR 35
TC 105
Z9 109
U1 3
U2 26
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 2048-8726
EI 2048-8734
J9 EUR HEART J-ACUTE CA
JI Eur. Heart J.-Acute Cardiovasc. Care
PD DEC
PY 2019
VL 8
IS 8
BP 762
EP 770
DI 10.1177/2048872617741733
PG 9
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA JT5NZ
UT WOS:000501037700011
PM 29206050
OA Bronze
DA 2025-06-11
ER

PT J
AU Ramamoorthi, R
   Gahreman, D
   Moss, S
   Skinner, T
AF Ramamoorthi, Ramya
   Gahreman, Daniel
   Moss, Simon
   Skinner, Timothy
TI The effectiveness of yoga to prevent diabetes mellitus type 2 A protocol
   for systematic review and meta-analysis
SO MEDICINE
LA English
DT Review
DE meta-analyses; prediabetes; protocol; systematic review; yoga
ID LIFE-STYLE INTERVENTION; DISEASE PROGRESSION; RISK-FACTORS; STRESS;
   INTERLEUKIN-6
AB Background: Type 2 diabetes mellitus (T2DM) is becoming a leading problem worldwide. Emerging reports reveal alarming evidence of increasing prevalence of T2DM that has reached pandemic levels. Despite the significant incidence, there are limited reliable data resources and comprehensive systematic review and meta-analysis on the effects of yoga on people who are a prediabetic or high risk for developing T2DM.
   Objective: The objective of this protocol is to conduct a full-scale systematic review and meta-analyses on the effects of yoga on people who are prediabetes or high risk of developing T2DM.
   Methods: The articles enrolled in the study will be retrieved from the online databases between 2002 and the date the searches are executed. The searches will be repeated just before the final analyses and further relevant studies for inclusion. We will conduct a bibliographic search in databases: Medline/PubMed, Scopus, Cochrane Library, EBSCO, and IndMED using keywords including prediabetes state, high risk for diabetes, metabolic syndrome, and yoga. A defined search strategy will be implemented along with selection criteria to obtain full-text articles of relevant studies. This study protocol was prepared according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis for Protocols 2015 guidelines. There will be no language restrictions.
   Ethics and dissemination: The proposed study will be based on published studies and publicly available anonymized data without directly involving human participants and therefore requires neither formal human ethical review nor approval by a human research ethics committee. We published an outline of the protocol in the International Prospective Register of Systematic Reviews (PROSPERO) in 2018. We plan to disseminate the findings of this systematic review and meta-analysis through publication in a peer-reviewed journal and presentation at relevant conference proceedings. In addition, we believe the results of the systematic review will have implications for policy and practice. We will prepare policymaker summary using a validated format, disseminate through social media and email discussion groups.
   Review registration number: PROSPERO registration number CRD 42018106657
C1 [Ramamoorthi, Ramya; Gahreman, Daniel; Moss, Simon] Charles Darwin Univ, Coll Hlth & Human Sci, Darwin, NT, Australia.
   [Skinner, Timothy] Univ Copenhagen, Ctr Sundhed & Samfund, Inst Psykol, Copenhagen, Denmark.
C3 Charles Darwin University; University of Copenhagen
RP Ramamoorthi, R (corresponding author), Charles Darwin Univ, Coll Hlth & Human Sci, Clin Sci, Blue 5-1-43,Ellengowan Dr, Darwin, NT 0909, Australia.
EM Ramya.Ramamoorthi@cdu.edu.au
RI ; Skinner, Timothy/N-2221-2013
OI Ramamoorthi, Ramya/0000-0001-8325-1785; Gahreman,
   Daniel/0000-0002-2375-6746; Skinner, Timothy/0000-0002-0018-6963
CR [Anonymous], FACT SHEET DIAB
   [Anonymous], J BANGLA SOC PHYSL
   [Anonymous], THESIS
   [Anonymous], N AM YOGA PRACTITION
   Black PH, 2003, BRAIN BEHAV IMMUN, V17, P350, DOI 10.1016/S0889-1591(03)00048-5
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NR 37
TC 4
Z9 4
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD JAN
PY 2019
VL 98
IS 3
AR e14019
DI 10.1097/MD.0000000000014019
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA HQ3EZ
UT WOS:000462294100022
PM 30653107
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Xu, QY
   Zhang, M
   Abeysekera, IR
   Wang, XL
AF Xu, Qiyao
   Zhang, Mei
   Abeysekera, Iruni R.
   Wang, Xiaolong
TI High serum uric acid levels may increase mortality and major adverse
   cardiovascular events in patients with acute myocardial infarction
SO SAUDI MEDICAL JOURNAL
LA English
DT Review
ID CORONARY-HEART-DISEASE; METABOLIC-SYNDROME; HYPERTENSIVE PATIENTS;
   OXIDATIVE STRESS; HYPERURICEMIA; METAANALYSIS; ALLOPURINOL; ASSOCIATION;
   FENOFIBRATE; CLOPIDOGREL
AB Objectives: To determine the validity of uric acid as a potential prognostic marker for long-term outcomes of patients with acute myocardial infarction (AMI) and those with AMI undergoing percutaneous coronary intervention (PCI).
   Methods: Systematic review and meta-analysis were performed. We retrieved data from retrospective and prospective cohort studies that investigated whether serum uric acid (SUA) level affects the prognosis of patients with AMI.
   Results: Thirteen studies involving 9371 patients were included. High serum uric acid (HSUA) level increased mid/long-term mortality (risk ratio (RR)=2.32, 95% confidence intervals (CI): 2.00-2.70) and had higher short-term mortality (RR=3.09, 95% CI: 2.58-3.71), higher mid/long-term major adverse cardiovascular events (MACE) risk (RR=1.70, 95% CI: 1.54-1.88), and higher short-term MACE risk (RR=2.47, 95% CI: 2.08-2.92) for patients with AMI. In the PCI subgroup, the HSUA level also increased mid/long-term mortality (RR=2.33, 95% CI: 1.89 to 2.87) and had higher mid/long-term MACE risk (RR=1.64, 95% CI: 1.48-1.82), and higher short-term MACE risk (RR 2.43, 95% CI: 2.02-2.93) for patients who were treated with PCI after AMI. Particularly in the PCI subgroup, a higher short-term mortality (RR=6.70, 95% CI: 3.14-14.31) was presented in the group with lower HSUA cut-off level, and the mortality was higher than the group with higher HSUA cut-off level (RR=2.69, 95% CI: 2.09-3.46).
   Conclusion: The HSUA level significantly increased the mortality and MACE risk of patients with AMI. Mild elevation of SUA levels (normal range) have started to have a significant impact on the short-term mortality of patients who underwent PCI, and has not received the attention of previous studies. However, this condition should be further investigated.
C1 [Xu, Qiyao; Zhang, Mei] Univ PAP, Cardiol Ctr, Affiliated Hosp Logist, Tianjin, Peoples R China.
   [Abeysekera, Iruni R.] Tianjin Med Univ, Dept Physiol & Pathophysiol, Tianjin, Peoples R China.
   [Xu, Qiyao] Second Peoples Hosp Yichang, Yichang, Hubei, Peoples R China.
   [Wang, Xiaolong] Tech Univ Munich, Klinikum Rechts Isar, Munich, Germany.
C3 Tianjin Medical University; Technical University of Munich
RP Zhang, M (corresponding author), Univ PAP, Cardiol Ctr, Affiliated Hosp Logist, Tianjin, Peoples R China.
EM dr_zhangmei@163.com
RI WANG, XIAOLONG/AAA-4301-2022
OI xu, qi yao/0000-0003-3426-4541; Abeysekera, Iruni
   Roshanie/0000-0002-6284-356X; Wang, Xiaolong/0000-0001-6142-9722
FU Natural Science Foundation of Tianjin, China [16JCZDJC31900];
   International Student's Science & Technology Innovation Project of
   Tianjin Medical University, China [2110/2GJ006]
FX The authors declare that there is no conflict of interest regarding the
   publication of this article, and the work was not supported or funded by
   any drug company. This project is funded by the Natural Science
   Foundation of Tianjin, China (Grant number: 16JCZDJC31900) and
   International Student's Science & Technology Innovation Project
   (Scientific Research Project number: 2110/2GJ006) of Tianjin Medical
   University, China.
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NR 54
TC 18
Z9 21
U1 0
U2 9
PU SAUDI MED J
PI RIYADH
PA ARMED FORCES HOSPITAL, PO BOX 7897,, RIYADH 11159, SAUDI ARABIA
SN 0379-5284
EI 1658-3175
J9 SAUDI MED J
JI Saudi Med. J.
PD JUN
PY 2017
VL 38
IS 6
BP 577
EP 585
DI 10.15537/smj.2017.6.17190
PG 9
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA EY8CX
UT WOS:000404223100001
PM 28578435
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Qiu, SQ
   Mintz, JD
   Salet, CD
   Han, WH
   Giannis, A
   Chen, F
   Yu, YF
   Su, YC
   Fulton, DJ
   Stepp, DW
AF Qiu, Shuiqing
   Mintz, James D.
   Salet, Christina D.
   Han, Weihong
   Giannis, Athanassios
   Chen, Feng
   Yu, Yanfang
   Su, Yunchao
   Fulton, David J.
   Stepp, David W.
TI Increasing Muscle Mass Improves Vascular Function in Obese
   (db/db) Mice
SO JOURNAL OF THE AMERICAN HEART ASSOCIATION
LA English
DT Article
DE muscle mass; myostatin; NOX1; oxidant stress; tetrahydrobiopterin;
   vasodilation
ID INSULIN-RESISTANCE; SKELETAL-MUSCLE; ENDOTHELIAL FUNCTION; NITRIC-OXIDE;
   PHYSICAL-ACTIVITY; MYOSTATIN INHIBITION; METABOLIC SYNDROME;
   BLOOD-PRESSURE; EXERCISE; TETRAHYDROBIOPTERIN
AB Background-A sedentary lifestyle is an independent risk factor for cardiovascular disease and exercise has been shown to ameliorate this risk. Inactivity is associated with a loss of muscle mass, which is also reversed with isometric exercise training. The relationship between muscle mass and vascular function is poorly defined. The aims of the current study were to determine whether increasing muscle mass by genetic deletion of myostatin, a negative regulator of muscle growth, can influence vascular function in mesenteric arteries from obese db/db mice.
   Methods and Results-Myostatin expression was elevated in skeletal muscle of obese mice and associated with reduced muscle mass (30% to 50%). Myostatin deletion increased muscle mass in lean (40% to 60%) and obese (80% to 115%) mice through increased muscle fiber size (P<0.05). Myostatin deletion decreased adipose tissue in lean mice, but not obese mice. Markers of insulin resistance and glucose tolerance were improved in obese myostatin knockout mice. Obese mice demonstrated an impaired endothelial vasodilation, compared to lean mice. This impairment was improved by superoxide dismutase mimic Tempol. Deletion of myostatin improved endothelial vasodilation in mesenteric arteries in obese, but not in lean, mice. This improvement was blunted by nitric oxide (NO) synthase inhibitor L-NG-nitroarginine methyl ester (L-NAME). Prostacyclin (PGI(2))- and endothelium-derived hyperpolarizing factor (EDHF)-mediated vasodilation were preserved in obese mice and unaffected by myostatin deletion. Reactive oxygen species) was elevated in the mesenteric endothelium of obese mice and down-regulated by deletion of myostatin in obese mice. Impaired vasodilation in obese mice was improved by NADPH oxidase inhibitor (GKT136901). Treatment with sepiapterin, which increases levels of tetrahydrobiopterin, improved vasodilation in obese mice, an improvement blocked by L-NAME.
   Conclusions-Increasing muscle mass by genetic deletion of myostatin improves NO-, but not PGI(2)- or EDHF-mediated vasodilation in obese mice; this vasodilation improvement is mediated by down-regulation of superoxide.
C1 [Qiu, Shuiqing; Mintz, James D.; Salet, Christina D.; Han, Weihong; Giannis, Athanassios; Chen, Feng; Yu, Yanfang; Su, Yunchao; Fulton, David J.; Stepp, David W.] Georgia Regents Univ, Vasc Biol Ctr, Augusta, GA 30907 USA.
   [Qiu, Shuiqing; Mintz, James D.; Salet, Christina D.; Han, Weihong; Giannis, Athanassios; Chen, Feng; Yu, Yanfang; Su, Yunchao; Fulton, David J.; Stepp, David W.] Georgia Regents Univ, Dept Physiol, Augusta, GA 30907 USA.
   [Han, Weihong; Su, Yunchao] Georgia Regents Univ, Dept Pharmacol, Augusta, GA 30907 USA.
   [Giannis, Athanassios] Univ Leipzig, Inst Organ Chem, D-04109 Leipzig, Germany.
C3 University System of Georgia; Augusta University; University System of
   Georgia; Augusta University; University System of Georgia; Augusta
   University; Leipzig University
RP Stepp, DW (corresponding author), Georgia Regents Univ, Vasc Biol Ctr, 1459 Laney Walker Blvd, Augusta, GA 30907 USA.
EM dstepp@gru.edu
RI Yu, Yan/C-7031-2012; Stepp, David/F-4250-2011; Chen, Feng/E-1133-2011
OI Chen, Feng/0000-0003-3508-8834
FU NIH [R01 HL092446, R21 HL098829]; American Heart Association
   [13PRE14680055]; American Heart Association (AHA) [13PRE14680055]
   Funding Source: American Heart Association (AHA)
FX This work was supported by the NIH (R01 HL092446 and R21 HL098829; to
   Stepp and Fulton) and an American Heart Association predoctoral
   fellowship (13PRE14680055; to Qiu).
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NR 62
TC 28
Z9 30
U1 0
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2047-9980
J9 J AM HEART ASSOC
JI J. Am. Heart Assoc.
PD JUN
PY 2014
VL 3
IS 3
AR e000854
DI 10.1161/JAHA.114.000854
PG 18
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA V41RD
UT WOS:000209562400024
PM 24965025
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Heltemes, A
   Gingery, A
   Soldner, ELB
   Bozadjieva, N
   Jahr, KN
   Johnson, BK
   Gilbert, JS
AF Heltemes, Alaina
   Gingery, Anne
   Soldner, Emma L. B.
   Bozadjieva, Nadejda
   Jahr, Kristen N.
   Johnson, Britt K.
   Gilbert, Jeffrey S.
TI Chronic placental ischemia alters amniotic fluid milieu and results in
   impaired glucose tolerance, insulin resistance and hyperleptinemia in
   young rats
SO EXPERIMENTAL BIOLOGY AND MEDICINE
LA English
DT Article
DE pregnancy; hypertension; diabetes; fetal programming; pre-eclampsia;
   IGF-2
ID REDUCED UTERINE PERFUSION; INTRAUTERINE GROWTH RESTRICTION; MATERNAL
   NUTRIENT RESTRICTION; FETAL-GROWTH; PREGNANT RATS; UTEROPLACENTAL
   INSUFFICIENCY; DEVELOPMENTAL ORIGINS; METABOLIC SYNDROME;
   DIABETES-MELLITUS; PROTEIN-DIET
AB Although small size at birth is associated with hypertension and associated co-morbidities such as insulin resistance and type II diabetes mellitus, many of the animal models employed to simulate this phenomenon do not closely mimic the ontogeny of growth restriction observed clinically. While intrauterine growth restriction (IUGR) is often detected near mid-pregnancy in women and persists until term, most rodent models of IUGR employ ligation of uterine arteries for a brief period during late gestation (days 19-21 of pregnancy). We hypothesized that IUGR associated with chronic reduction in uteroplacental perfusion (RUPP) and placental ischemia during the third trimester of pregnancy in the rat alters the amniotic fluid (AF) environment and results in hypertensive offspring presenting with metabolic abnormalities such as glucose intolerance and insulin resistance. Insulin-like growth factor-1 (IGF-1), IGF-2, Na+ concentration and oxidative stress in the AF were increased, while K+ concentration was decreased in the RUPP compared with normal pregnant (NP) fetuses. RUPP-offspring (RUPP-O) were smaller (6.1 +/- 0.2 versus 6.7 +/- 0.2 g; P < 0.05) at birth compared with NP-offspring (NP-O) groups. At nine weeks of age, mean arterial pressure (121 +/- 3 versus 107 +/- 5 mmHg; P < 0.05), fasting insulin (0.71 +/- 0.014 versus 0.30 +/- 0.08 ng/mL; P < 0.05), glucose (4.4 +/- 0.2 versus 3.1 +/- 0.3 mmol/L; P < 0.05), leptin (3.8 +/- 0.5 versus 2.3 +/- 0.3 ng/mL; P < 0.05) and the homeostasis model assessment of insulin resistance index was greater (2.9 +/- 0.6 versus 1.0 +/- 0.3; P < 0.05) in the RUPP-O compared with the NP-O rats. These data indicate that chronic placental ischemia results in numerous alterations to the fetal environment that contributes to the development of impaired glucose metabolism, insulin resistance and hyperleptinemia in young offspring.
C1 [Heltemes, Alaina; Gingery, Anne; Soldner, Emma L. B.; Bozadjieva, Nadejda; Jahr, Kristen N.; Johnson, Britt K.; Gilbert, Jeffrey S.] Univ Minnesota Med Sch Duluth, Dept Physiol & Pharmacol, Duluth, MN 55812 USA.
C3 University of Minnesota System; University of Minnesota Duluth
RP Gilbert, JS (corresponding author), Univ Minnesota Med Sch Duluth, Dept Physiol & Pharmacol, 1035 Univ Dr, Duluth, MN 55812 USA.
EM jgilbert@d.umn.edu
RI Gilbert, Jeffrey/G-4930-2013; Gingery, Anne/GVS-2792-2022; Bozadjieva
   Kramer, Nadejda/KJM-7543-2024
OI Gingery, Anne/0000-0002-1690-7382; Bozadjieva Kramer,
   Nadejda/0000-0001-9796-2916
FU National Institutes of Health [GM074628]; American Heart Association
   [10SDG2600040]; University of Minnesota Graduate School; American Heart
   Association (AHA) [10SDG2600040] Funding Source: American Heart
   Association (AHA)
FX This work was supported in part by grants from National Institutes of
   Health GM074628, American Heart Association 10SDG2600040 and a
   Grant-in-Aid from the University of Minnesota Graduate School.
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NR 54
TC 40
Z9 48
U1 0
U2 4
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1535-3702
EI 1535-3699
J9 EXP BIOL MED
JI Exp. Biol. Med.
PD JUL
PY 2010
VL 235
IS 7
BP 892
EP 899
DI 10.1258/ebm.2010.009357
PG 8
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 622AI
UT WOS:000279628800014
PM 20558843
DA 2025-06-11
ER

PT J
AU Saenz-Medina, J
   Dos Santos, VG
   Rodriguez-Monsalve, M
   Muriel-Garcia, A
   Duran-Poveda, M
   del Val, AG
   Revilla, JB
   Prieto, D
AF Saenz-Medina, Javier
   Dos Santos, Victoria Gomez
   Rodriguez-Monsalve, Maria
   Muriel-Garcia, Alfonso
   Duran-Poveda, Manuel
   del Val, Alfonso Gomez
   Revilla, Javier Burgos
   Prieto, Dolores
TI Cardiovascular and Cerebrovascular Morbidity in Patients with
   Urolithiasis: An Epidemiological Approach Based on Hospitalization
   Burden Data from 1997 to 2021
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Article
DE urolithiasis; coronary heart disease; cerebrovascular disease;
   endothelial dysfunction; epidemiology
ID KIDNEY-STONES; ENDOTHELIAL DYSFUNCTION; METABOLIC SYNDROME; OXIDATIVE
   STRESS; RISK; OBESITY; HYPERTENSION; ASSOCIATION; HISTORY; DISEASE
AB Background: Patients with kidney stones (KSFs) are known to have a heightened risk of coronary heart disease (CHD) or stroke. The objective of the present study was to describe the natural history of these complications through the longitudinal analysis of the hospitalizations due to kidney stones in Spain from 1997 to 2021. Methods: A retrospective longitudinal observational study was developed based on nationwide hospitalization data (minimum basic data base). Three different analyses were carried out. In the first step, the prevalence of coronary or cerebrovascular events in kidney stone hospitalizations was compared with the hospitalization burden of CHD or strokes related to the general population. In the second step, a survival analysis of the kidney stones-hospitalized patients using the Kaplan-Meier method was conducted. In the third step, a Cox regression was used to assess the influence of the classical comorbidities in the development of the lithiasic patients-cardiovascular disease. Results: Kidney stone-hospitalized patients exhibit a significantly higher risk of CHD (OR = 14.8 CI95%: 14.7-14.9) and stroke (OR = 6.7 CI95%: 6.6-6.8) compared to the general population across in all age groups, although they had less cardiovascular risk factors. A total of 9352 KSFs (1.5%) developed a coronary event within an average time of 78.8 months. A total of 2120 KSFs (0.33%) suffered a stroke in an average time of 71.1 months. Diabetes, hypertension, hyperlipidemia, and being overweight were identified as risk factors for developing CHD and stroke using a univariate and multivariate analysis. Conclusions: Our study confirms previous studies in which kidney stones must be considered as a risk factor for developing CHD or cerebrovascular disease. Preventive strategies should target patients with kidney stones and classical risk cardiovascular factors to mitigate modifiable conditions associated with cardiovascular diseases.
C1 [Saenz-Medina, Javier; Rodriguez-Monsalve, Maria] Puerta Hierro Majadahonda Univ Hosp, Dept Urol, Calle Manuel Falla 1, Majadahonda 28222, Spain.
   [Saenz-Medina, Javier; Rodriguez-Monsalve, Maria; Duran-Poveda, Manuel; Prieto, Dolores] King Juan Carlos Univ, Dept Med Specialties & Publ Hlth, Madrid 28922, Spain.
   [Dos Santos, Victoria Gomez; Revilla, Javier Burgos] Ramon & Cajal Univ Hosp, Dept Urol, Madrid 28034, Spain.
   [Muriel-Garcia, Alfonso] Ramon & Cajal Univ Hosp, Dept Clin Biostat, Madrid 28034, Spain.
   [del Val, Alfonso Gomez] Univ Complutense, Pharm Fac, Dept Physiol, Madrid 28040, Spain.
C3 Hospital Puerta de Hierro-Majadahonda; Universidad Rey Juan Carlos;
   Hospital Universitario Ramon y Cajal; Hospital Universitario Ramon y
   Cajal; Complutense University of Madrid
RP Saenz-Medina, J (corresponding author), Puerta Hierro Majadahonda Univ Hosp, Dept Urol, Calle Manuel Falla 1, Majadahonda 28222, Spain.; Saenz-Medina, J (corresponding author), King Juan Carlos Univ, Dept Med Specialties & Publ Hlth, Madrid 28922, Spain.
EM javier.saenz@salud.madrid.org; vgomezd@salud.madrid.org;
   mrmonsalveherrero@salud.madrid.org; alfonso.muriel@uah.es;
   manuel.duran@hospitalreyjuancarlos.es; alfonsovaldelgomez@gmail.com;
   fjavier.burgos@salud.madrid.org; dprieto@ucm.es
RI Durán-Poveda, Manuel/AAS-6519-2021; Dos Santos, Victoria/I-8569-2019;
   PRIETO, DOLORES/S-8172-2018; Saenz Medina, Javier/E-9391-2016; Muriel,
   Alfonso/F-9948-2015
OI PRIETO, DOLORES/0000-0001-7049-5991; Saenz Medina,
   Javier/0000-0002-8568-854X; Muriel, Alfonso/0000-0002-4805-4011;
   Duran-Poveda, Manuel/0000-0002-4335-7208
FU Spanish Ministry of Science and Innovation [PID2019-105689RB,
   PID2022-140536OB-I00]
FX This work was supported by PID2019-105689RB and PID2022-140536OB-I00
   from the Spanish Ministry of Science and Innovation.
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NR 38
TC 0
Z9 0
U1 1
U2 1
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD JUN
PY 2024
VL 13
IS 12
AR 3564
DI 10.3390/jcm13123564
PG 12
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA WQ8W0
UT WOS:001256439200001
PM 38930093
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Brady, TM
   Horst, G
   Appel, LJ
   Khoury, PR
   Urbina, EM
AF Brady, Tammy M.
   Horst, Gilbert
   Appel, Lawrence J.
   Khoury, Philip R.
   Urbina, Elaine M.
TI Dietary sodium intake and sodium load is associated with arterial
   stiffness in children and young adults
SO JOURNAL OF HYPERTENSION
LA English
DT Article
DE cardiovascular disease; pediatrics; vascular aging; vascular disease
ID PULSE-WAVE VELOCITY; LEFT-VENTRICULAR HYPERTROPHY; CARDIOVASCULAR
   RISK-FACTORS; BLOOD-PRESSURE; AORTIC STIFFNESS; SCIENTIFIC STATEMENT;
   HYPERTENSION PREVENTION; INDEPENDENT PREDICTOR; AUGMENTATION INDEX;
   METABOLIC SYNDROME
AB Objective: The aim of this study was to examine the association of sodium intake (g/day) and sodium load (Na-L; mg/kcal/day) on arterial stiffness in youth. Methods: A cross-sectional analysis of 723 youth enrolled in a study evaluating the cardiovascular effects of obesity and type 2 diabetes mellitus (T2DM). Three measures of arterial stiffness were evaluated: brachial distensibility (BrachD), carotid-femoral pulse wave velocity (PWVcf) and augmentation index (AIx). Three-day diet histories yielded mean daily sodium and calorie intake. Youth were divided into Na-L tertiles: Low (<= 1.67 mg/kcal per day); Medium (1.68--1.98 mg/kcal per day) and High (>1.98 mg/kcal per day). General linear models adjusting for demographics, % body fat, T2DM and SBP z-score evaluated the independent association of Na-L with arterial stiffness Results: Mean age was 17.9 years (10-24 years), 35% male, 59% nonwhite and 31% T2DM. Mean (+/- standard deviation) dietary intake was calories = 2074 (+/- 797) kcal/day; Na = 3.793 (+/- 1567) g/day; Na- = 1.86 (+/- 0.753) mg/kcal per day. With higher levels of dietary Na intake and Na-L, measures of arterial stiffness worsened: BrachD decreased (Na intake: beta = -0.09, P = 0.003; Na-L: beta = -0.28, P < 0.0001), PWVcf increased (Na intake: beta = 0.07, P = 0.007; Na-L: beta = 0.21, P < 0.0001) but AIx did not change (Na intake: beta = -0.4, P = 0.2; Na-L: beta = 0.89, P = 0.11). In multivariable analysis, High Na-L was independently associated with BrachD, PWVcf and AIx (P < 0.05 for all), with age modifying the association of High Na-L with PWVcf and AIx. Conclusion: Sodium intake and load are associated with arterial stiffness, a preclinical measure of CVD, among a paediatric population. Paediatricians should stress healthy dietary choices to reduce accelerated vascular ageing.
C1 [Brady, Tammy M.; Horst, Gilbert; Appel, Lawrence J.] Johns Hopkins Univ, Baltimore, MD USA.
   [Khoury, Philip R.; Urbina, Elaine M.] Cincinnati Childrens Hosp Med Ctr, Cincinnati, OH 45229 USA.
C3 Johns Hopkins University; Cincinnati Children's Hospital Medical Center
RP Brady, TM (corresponding author), David M Rubenstein Child Hlth Bldg,200 N Wolfe, Baltimore, MD 21287 USA.
EM tbrady8@jhmi.edu
RI Appel, Larry/GLT-2608-2022
FU NIH/NHLBI [R56-HL139620, R01 HL076269, R01 HL105591-01]; National Center
   for Advancing Translational Sciences of the National Institutes of
   Health
FX An earlier version of part of this work was presented as a Platform
   Presentation at the Pediatric Academic Society's annual meeting in 2017.
   T.M.B. was supported by the NIH/NHLBI (R56-HL139620). E.M.U. and P.R.K.
   were supported by R01 HL076269, R01 HL105591-01 and the National Center
   for Advancing Translational Sciences of the National Institutes of
   Health under
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NR 60
TC 5
Z9 9
U1 0
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0263-6352
EI 1473-5598
J9 J HYPERTENS
JI J. Hypertens.
PD FEB
PY 2022
VL 40
IS 2
BP 292
EP 299
DI 10.1097/HJH.0000000000003007
PG 8
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA YC7CS
UT WOS:000739845900014
PM 34475346
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Xing, YL
   Cheng, TT
   Zhou, F
   Ma, HJ
AF Xing, Yuling
   Cheng, Tiantian
   Zhou, Fei
   Ma, Huijuan
TI The Association Between Vitamin D and Type 2 Diabetes Mellitus
   Complicated with Non-Alcoholic Fatty Liver Disease: An Observational
   Cross-Sectional Study
SO DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
LA English
DT Article
DE type 2 diabetes mellitus; non-alcoholic fatty liver disease; vitamin D
ID BODY-MASS INDEX; METABOLIC SYNDROME; D SUPPLEMENTATION; OXIDATIVE
   STRESS; D DEFICIENCY; INCREASED RISK; STEATOHEPATITIS; OBESITY;
   INFLAMMATION; METAANALYSIS
AB Objective: To investigate the association between vitamin D deficiency and NAFLD risk in patients with type 2 diabetes mellitus Methods: Overall, 434 patients with T2DM admitted to Hebei General Hospital from January 2019 to December 2019 were selected as the study subjects. According to abdominal ultrasound findings, patients were divided into the NAFLD group and the non-NAFLD group. Participants were divided into two study groups according to the 25-hydroxyvitamin D [25(OH)D] level. 25(OH)D deficiency was defined if 25(OH)D vitamin levels were <20 ng/mL. Chi-square test and one-way analysis of variance were used to compare groups. The relationship between 25(OH)D and NAFLD risk was analyzed using correlation and regression analyses. Furthermore, subgroup analyses were performed to verify the robustness of the results. Results: The 25(OH)D level in patients with T2DM complicated by NAFLD was significantly lower than in patients with T2DM only. Vitamin D deficiency was highly prevalent among T2DM patients with NAFLD. This study suggested that vitamin D deficiency was an independent factor for developing NAFLD in patients with T2DM. T2DM patients with vitamin D deficiency had 2.045 times higher risk of developing NAFLD than those without vitamin D deficiency. Vitamin D deficiency was associated with high NAFLD preference in T2DM patients with BMI >23kg/m2, but not those with BMI <= 23kg/m2. The significant correlation between vitamin D deficiency and NAFLD was found in participants with BMI >23kg/m2, age <= 65 years, without hypertension, TG <1.7mmol/l, HDL >= 1 mmol/l in men, >= 1.3 mmol/l in women, HBA1C <= 7%, or females. Conclusion: This study suggests that T2DM people with BMI >23kg/m2 were more susceptible to NAFLD by vitamin D deficiency and that it is necessary to maintain optimal serum vitamin D levels in this population.
C1 [Xing, Yuling; Cheng, Tiantian; Zhou, Fei; Ma, Huijuan] Hebei Gen Hosp, Dept Endocrinol, Shijiazhuang 050017, Hebei, Peoples R China.
   [Xing, Yuling; Zhou, Fei] Hebei Med Univ, Grad Sch, Shijiazhuang 050017, Hebei, Peoples R China.
   [Cheng, Tiantian] North China Univ Sci & Technol, Sch Clin Med, Dept Internal Med, Tangshan 063210, Hebei, Peoples R China.
   [Ma, Huijuan] Hebei Gen Hosp Shijiazhuang, Hebei Key Lab Metab Dis, Shijiazhuang 050051, Hebei, Peoples R China.
   [Ma, Huijuan] Hebei Med Univ, Dept Internal Med, Shijiazhuang 050017, Hebei, Peoples R China.
C3 Hebei Medical University; North China University of Science &
   Technology; Hebei Medical University
RP Ma, HJ (corresponding author), Hebei Gen Hosp, Dept Endocrinol, Shijiazhuang 050017, Hebei, Peoples R China.; Ma, HJ (corresponding author), Hebei Gen Hosp Shijiazhuang, Hebei Key Lab Metab Dis, Shijiazhuang 050051, Hebei, Peoples R China.; Ma, HJ (corresponding author), Hebei Med Univ, Dept Internal Med, Shijiazhuang 050017, Hebei, Peoples R China.
EM xingyl95@163.com; huijuanma19@163.com
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NR 70
TC 4
Z9 7
U1 1
U2 11
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-7007
J9 DIABET METAB SYND OB
JI Diabetes Metab. Syndr. Obes.
PY 2022
VL 15
BP 269
EP 280
DI 10.2147/DMSO.S348870
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA YU1AG
UT WOS:000751781400002
PM 35140487
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Soares, S
   Santos, AC
   Peres, FS
   Barros, H
   Fraga, S
AF Soares, Sara
   Santos, Ana Cristina
   Peres, Flavia Soares
   Barros, Henrique
   Fraga, Silvia
TI Early life socioeconomic circumstances and cardiometabolic health in
   childhood: Evidence from the Generation XXI cohort
SO PREVENTIVE MEDICINE
LA English
DT Article
DE Cardiometabolic health; Cardiometabolic biomarkers; Socioeconomic
   circumstances; Health inequalities; Social adversity biology
ID CAUSE-SPECIFIC MORTALITY; METABOLIC SYNDROME; CARDIOVASCULAR RISK;
   EXPERIENCES; OBESITY; STRESS; DISADVANTAGE; ADULTHOOD; PATTERNS;
   POSITION
AB Social adversity is thought to become biologically embedded during sensitive periods of development which could set children on a trajectory of increased risk for later diseases. This study estimated the association between early socioeconomic circumstances and cardiometabolic biomarkers during childhood.
   We analyzed data from 2962 participants in the birth cohort Generation XXI. Early socioeconomic circumstances included parental education and occupation and household income measured at the child's birth; cardiometabolic biomarkers included a set of parameters that were determined at seven and 10 years old. The association between early socioeconomic circumstances and cardiometabolic biomarkers in children aged seven and 10 years old was estimated using generalized estimating equations.
   We observed, after adjustment for birth weight, sex, five-a-day fruit and vegetable intake and sedentary activity, that children with low educated mothers presented higher body mass index z-score (beta = 0.22; 95%CI: 0.12, 0.33), higher waist circumference (beta = 1.14; 95%CI: 0.55, 1.73) and increased systolic blood pressure z-score (beta = 0.15; 95%CI: 0.08, 0.22) at the age of seven. At 10 years, children with mothers with low education, presented higher body mass index z-score (beta = 0.32; 95%CI: 0.21, 0.43), higher waist circumference (beta = 2.79; 95%CI: 1.94, 3.64), increased diastolic blood pressure z-score (beta = 0.11; 95%CI: 0.06, 0.17) and increased systolic blood pressure s-score (beta = 0.20; 95%CI: 0.12, 0.28). When repeated measures of cardiometabolic biomarkers were taken into account, the association between socioeconomic circumstances and cardiometabolic biomarkers remained significant.
   Low socioeconomic circumstances have a possible detrimental effect on children's cardiometabolic health. Thus, socioeconomic adversity might impact health outcomes already in the first decade of life, emphasizing the early social patterning of cardiometabolic health and the need of social policies targeting children and families to modify or reverse its negative impact on health.
C1 [Soares, Sara; Santos, Ana Cristina; Peres, Flavia Soares; Barros, Henrique; Fraga, Silvia] Univ Porto, Inst Saude Publ, EPIUnit, Porto, Portugal.
   [Soares, Sara; Santos, Ana Cristina; Barros, Henrique; Fraga, Silvia] Univ Porto, Fac Med, Dept Ciencias Saude Publ & Forenses & Educ Med, Porto, Portugal.
C3 Universidade do Porto; Universidade do Porto
RP Fraga, S (corresponding author), Univ Porto, Inst Saude Publ, Rua Taipas 135, P-4050600 Porto, Portugal.
EM silvia.fraga@ispup.up.pt
RI Santos, Ana/AAY-2314-2020; Soares, Sara/N-6285-2019; Barros,
   Henrique/A-5488-2008
OI Santos, Ana/0000-0002-2992-5299; Fraga, Silvia/0000-0002-5268-7751;
   Barros, Henrique/0000-0003-4699-6571; Soares Peres,
   Flavia/0000-0002-1306-1342; Soares, Sara/0000-0002-7996-0519
FU European Regional Development Fund (ERDF) through the Operational
   Programme Competitiveness and Internationalization; Foundation for
   Science and Technology (FCT), Portuguese Ministry of Science, Technology
   and Higher Education [POCI-01-0145-FEDER-016838, FCT
   PTDC/DTPEPI/1687/2014, POCI-01-0145-FEDER029567,
   PTDC/SAU-PUB/29567/2017, POCI-01-0145-FEDER-016837, FCT
   PTDC/DTP-EPI/3306/2014]; Unidade de Investigacao em Epidemiologia
   -Instituto de Saude Publica da Universidade do Porto (EPIUnit)
   [POCI-01-0145-FEDER-006862, UID/DTP/04750/2013]; Administracao Regional
   de Saude Norte (Regional Department of Ministry of Health); Fundacao
   Calouste Gulbenkian; FCT [SFRH/BD/108742/2015,
   CEECIND/01516/2017/CP1406/CT0001, IF/01060/2015]; Human Capital
   Operational Programme (POCH/FSE Program) [SFRH/BD/108742/2015]; Norte
   Portugal Regional Operational Programme (NORTE 2020), under the PORTUGAL
   2020 Partnership Agreement [NORTE-01-0145-FEDER-000003]; Fundação para a
   Ciência e a Tecnologia [CEECIND/01516/2017/CP1406/CT0001,
   SFRH/BD/108742/2015] Funding Source: FCT
FX This work was supported by the European Regional Development Fund (ERDF)
   through the Operational Programme Competitiveness and
   Internationalization and national funding from the Foundation for
   Science and Technology (FCT), Portuguese Ministry of Science, Technology
   and Higher Education under the projects "BioAdversity: How childhood
   social adversity shapes health: The biology of social adversity"
   (POCI-01-0145-FEDER-016838; Reference FCT PTDC/DTPEPI/1687/2014),
   "HIneC: When do health inequalities start? Understanding the impact of
   childhood social adversity on health trajectories from birth to early
   adolescence" (POCI-01-0145-FEDER029567; Reference:
   PTDC/SAU-PUB/29567/2017), and "PathMOB: Pathways from early life to
   cardiometabolic risk during childhood" (POCI-01-0145-FEDER-016837;
   Reference FCT PTDC/DTP-EPI/3306/2014). It is also supported by the
   Unidade de Investigacao em Epidemiologia -Instituto de Saude Publica da
   Universidade do Porto (EPIUnit) (POCI-01-0145-FEDER-006862; Reference
   UID/DTP/04750/2013), Administracao Regional de Saude Norte (Regional
   Department of Ministry of Health) and Fundacao Calouste Gulbenkian; PhD
   Grant SFRH/BD/108742/2015 (to SS) co-funded by FCT and the Human Capital
   Operational Programme (POCH/FSE Program); FCT Investigator contracts
   CEECIND/01516/2017/CP1406/CT0001 (to SF) and IF/01060/2015 (to ACS).
   This study is also a result of the project DOCnet
   (NORTE-01-0145-FEDER-000003), supported by the Norte Portugal Regional
   Operational Programme (NORTE 2020), under the PORTUGAL 2020 Partnership
   Agreement.
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NR 55
TC 3
Z9 4
U1 0
U2 7
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0091-7435
EI 1096-0260
J9 PREV MED
JI Prev. Med.
PD APR
PY 2020
VL 133
AR 106002
DI 10.1016/j.ypmed.2020.106002
PG 11
WC Public, Environmental & Occupational Health; Medicine, General &
   Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; General & Internal Medicine
GA KZ9FW
UT WOS:000523565500005
PM 32007527
DA 2025-06-11
ER

PT J
AU Wang, K
   Hu, L
   Chen, JK
AF Wang, Kang
   Hu, Lei
   Chen, Jian-Kang
TI RIP3-deficience attenuates potassium oxonate-induced hyperuricemia and
   kidney injury
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Article
DE Hyperuricemia; RIP3; Inflammation; Necrosis and apoptosis
ID NF-KAPPA-B; OXIDATIVE STRESS; CELL-DEATH; URIC-ACID; INTESTINAL
   INFLAMMATION; PROGRAMMED NECROSIS; METABOLIC DISEASE; RIP3; APOPTOSIS;
   NECROPTOSIS
AB Recent preclinical and clinical evidence suggests that hyperuricemia (HU) is an independent risk factor for metabolic syndrome, hypertension, cardiovascular disease and chronic kidney disease. Receptor-interacting protein 3 (RIP3) is an important contributor in inducing programmed necrosis, representing a newly identified mechanism of cell death combining features of both apoptosis and necrosis. In our study, RIP3 was strongly expressed in mice with hyperuricemia. RIP3 deficiency attenuated hyperuricemia in mice, evidenced by reduced serum uric acid and creatinine and enhanced urinary uric acid and creatinine, as well as the improved histological alterations in renal sections. Additionally, RIP3-deletion reduced malondialdehyde (MDA), H2O2 and O-2(-), whereas enhanced superoxide dismutase (SOD), GSH and GSH-Px levels in potassium oxonate-induced mice. Potassium oxonate-treated mice showed significantly high mRNA levels of ATP-binding cassette, subfamily G, membrane 2 (ABCG2), organic anion transporter 1 (OAT1), OAT3, organic cation transporter 1 (OCT1) and organic cation/carnitine transporter 1 (OCTN1) in renal tissue samples, which were reversed by RIP3-deficiency. Meanwhile, down-regulation of circulating and kidney pro-inflammatory cytokines (IL-1 beta, TNF-alpha and IL-6) were observed in RIP3-knockout mice with hyperuricemia, associated with inactivation of toll-like receptor 4 (TLR4), inhibitor of NF-kappa B alpha (I kappa B alpha) and nuclear factor kappa B (NF-kappa B). NLR family, pyrin domain-containing 3 (NLRP3) inflammasome was also suppressed by RIP3 knockout in potassium oxonate-treated mice. Importantly, RIP3-knockout mice exhibited the decrease of FAS-associated protein with a death domain (FADD), cleaved Caspase-8/-3 and Poly (ADP-ribose) polymerase (PARP) in renal samples, along with TUNEL reduction in mice with hyperuricemia. Similar results were observed in uric acid-incubated cells with RIP3 knockdown. Thus, we suggested that RIP3 played an important role in mice with hyperuricemia, which might be a novel signal pathway targeting for therapeutic strategies in future.
C1 [Wang, Kang; Hu, Lei; Chen, Jian-Kang] Nanchang Univ, Affiliated Hosp 2, Dept Tradit Chinese Med, Nanchang 330006, Jiangxi, Peoples R China.
C3 Nanchang University
RP Chen, JK (corresponding author), Zhejiang Univ, Coll Med, Affiliated Hosp 1, Kidney Dis Ctr, Hangzhou 310000, Zhejiang, Peoples R China.
EM 2427235914@qq.com
RI chen, jia/JDW-7660-2023
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NR 47
TC 24
Z9 28
U1 2
U2 46
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD MAY
PY 2018
VL 101
BP 617
EP 626
DI 10.1016/j.biopha.2018.02.010
PG 10
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA GC2BG
UT WOS:000429586400071
PM 29518608
DA 2025-06-11
ER

PT J
AU Li, J
   Shi, Z
   Mi, YJ
AF Li, Jian
   Shi, Zhao
   Mi, Yongjie
TI Purple sweet potato color attenuates high fat-induced neuroinflammation
   in mouse brain by inhibiting MAPK and NF-B activation
SO MOLECULAR MEDICINE REPORTS
LA English
DT Article
DE neuroinflammation; high-fat diet; purple sweet potato color;
   mitogen-activated protein kinase; nuclear factor-B
ID WHITE ADIPOSE-TISSUE; OXIDATIVE STRESS; KAPPA-B; PARKINSONS-DISEASE;
   NLRP3 INFLAMMASOME; METABOLIC SYNDROME; PROTEIN-KINASES; DIETARY-FAT;
   ANTHOCYANINS; MICE
AB Purple sweet potato color (PSPC) is a natural anthocyanin pigment that is derived from purple sweet potato storage roots. PSPC possesses a variety of biological activities, including antioxidant, anti-inflammatory and neuroprotective effects; however, the detailed effects of PSPC on high-fat diet (HFD)-induced neuroinflammation remain to be determined. The aim of the present study was to investigate whether PSPC has a protective role in HFD-associated neuroinflammation in the mouse brain and to provide novel insight into the mechanisms of the action. C57BL 6J mice were maintained on a normal diet (10 kcal% fat), a HFD (60 kcal% fat), a HFD with PSPC (700 mg/kg/day) or PSPC alone, which was administrated over 20 weeks. Open field and step-through tests were used to evaluate the effects of HFD and PSPC on mouse behavior and memory function. Western blotting and ELISA analyses were used to assess the expression of inflammatory cytokines and the activation of mitogen-activated protein kinase and nuclear factor-B (NF-B). The results demonstrated that PSPC treatment was able to significantly improve the HFD-induced impairment of mouse behavior and memory function, and suppressed the increase in body weight, fat content, hyperlipemia and the level of endotoxin. PSPC treatment also markedly decreased the expression of cyclooxygenase-2, inducible nitric oxide synthase, tumor necrosis factor-, interleukin (IL)-1 and IL-6, and increased the level of IL-10 in the HFD-treated mouse brain. In addition, PSPC inhibited the HFD-induced phosphorylation of extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK) and p38, and the activation of NF-B. These findings indicated that PSPC treatment may alleviate HFD-induced neuroinflammation in the mouse brain by inhibiting ERK, JNK, p38 and NF-B activation.
C1 [Li, Jian; Shi, Zhao; Mi, Yongjie] Chengdu Med Coll, Dept Anat, Chengdu 610500, Sichuan, Peoples R China.
   [Mi, Yongjie] Hebei Univ Chinese Med, Dept Surg, 3 Xingyuan Rd, Shijiazhuang 050200, Hebei, Peoples R China.
C3 Chengdu Medical College; Hebei University of Chinese Medicine
RP Mi, YJ (corresponding author), Hebei Univ Chinese Med, Dept Surg, 3 Xingyuan Rd, Shijiazhuang 050200, Hebei, Peoples R China.
EM yongjiemi@126.com
FU Key Laboratory of Sichuan Province for Developmental Regeneration
   [SYS10-006]
FX The present study was funded by a Special Grant from the Key Laboratory
   of Sichuan Province for Developmental Regeneration (grant no.
   SYS10-006).
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NR 46
TC 24
Z9 26
U1 0
U2 25
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1791-2997
EI 1791-3004
J9 MOL MED REP
JI Mol. Med. Rep.
PD MAR
PY 2018
VL 17
IS 3
BP 4823
EP 4831
DI 10.3892/mmr.2018.8440
PG 9
WC Oncology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Research & Experimental Medicine
GA FV2MB
UT WOS:000424400000179
PM 29344660
OA Bronze
DA 2025-06-11
ER

PT J
AU Raghav, A
   Ahmad, J
   Alam, K
AF Raghav, Alok
   Ahmad, Jamal
   Alam, Khursheed
TI Nonenzymatic glycosylation of human serum albumin and its effect on
   antibodies profile in patients with diabetes mellitus
SO PLOS ONE
LA English
DT Article
ID ADVANCED GLYCATION ENDPRODUCTS; MODIFIED HUMAN DNA; METABOLIC SYNDROME;
   END-PRODUCTS; INFLAMMATORY RESPONSE; OXIDATIVE STRESS; URIC-ACID;
   RECEPTOR; RAGE; NEPHROPATHY
AB Background
   Albumin glycation and subsequent formation of advanced glycation end products (AGEs) correlate with diabetes and associated complications.
   Methods
   Human Serum Albumin (HSA) was modified with D-glucose for a 40 day period under sterile conditions at 37 degrees C. Modified samples along with native HSA (unmodified) were analyzed for structural modifications by UV and fluorescence, FTIR, Liquid chromatography mass spectrometry (LCMS) and X-ray crystallography. New-Zealand white female rabbits immunized with AGEs, represent auto-antibodies formation as assessed by competitive and direct binding enzyme-linked immunosorbent assay (ELISA). Neo-epitopesagainst In-vitro formed AGEs were characterized in patients with diabetes mellitus type 2 (n = 50), type 1 (n = 50), gestational diabetes (n = 50) and type 2 with chronic kidney disease (CKD) with eGFR level 60-89 mL/min (n = 50) from serum direct binding ELISA.
   Results
   Glycated-HSA showed a marked increase in hyperchromicity of 65.82%, 71.98%, 73.62% and 76.63% at. 280 nm along with anincreasein fluorescence intensity of 65.82%, 71.98%, 73.62% and 76.63% in glycated-HSA compared to native. FTIR results showed theshifting of Amide I peak from 1656 cm(-1) to 1659 cm(-1) and Amide II peak from 1554 cm(-1) to 1564 cm(-1) in glycated-HSA, with anew peak appearance of carbonyl group at 1737 cm-1. LCMS chromatogram of glycated-HSA showed thepresence of carboxymethyl lysine (CML) at 279.1 m/z. Immunological analysis showed high antibody titre> 1: 12,800 in theserum of rabbits immunized with glycated-HSA (modified with 400 mg/dL glucose) and inhibition of 84.65% at anantigen concentration of 20 mu g/mL. Maximum serum auto-antibody titre was found in T2DM (0.517 +/- 0.086), T1DM (0.108 +/- 0.092), GDM (0.611 +/- 0.041) and T2DM + CKD (0.096 +/- 0.25) patients immunized with glycated-HSA (modified with 400 mg/dL glucose).
   Conclusions
   Non-enzymatic glycosylation of HSA manifests immunological complications in diabetes mellitus due to change in its structure that enhances neo-epitopes generation.
C1 [Raghav, Alok; Ahmad, Jamal] Aligarh Muslim Univ, JN Med Coll, Rajiv Gandhi Ctr Diabet & Endocrinol, Aligarh, Uttar Pradesh, India.
   [Alam, Khursheed] Aligarh Muslim Univ, JN Med Coll, Fac Med, Dept Biochem, Aligarh, Uttar Pradesh, India.
C3 Aligarh Muslim University; Aligarh Muslim University
RP Ahmad, J (corresponding author), Aligarh Muslim Univ, JN Med Coll, Rajiv Gandhi Ctr Diabet & Endocrinol, Aligarh, Uttar Pradesh, India.
EM alokalig@gmail.com
RI Raghav, Alok/AAX-3419-2021
OI Alam, Khursheed/0000-0001-9729-9966; Ahmad, Jamal/0000-0001-9108-5019
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NR 55
TC 37
Z9 38
U1 0
U2 22
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAY 17
PY 2017
VL 12
IS 5
AR e0176970
DI 10.1371/journal.pone.0176970
PG 22
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA EV1DX
UT WOS:000401487700034
PM 28520799
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Forsyth, CB
   Voigt, RM
   Burgess, HJ
   Swanson, GR
   Keshavarzian, A
AF Forsyth, Christopher B.
   Voigt, Robin M.
   Burgess, Helen J.
   Swanson, Garth R.
   Keshavarzian, Ali
TI Circadian rhythms, alcohol and gut interactions
SO ALCOHOL
LA English
DT Article
DE Intestinal permeability; Alcohol; Circadian rhythms; Per2; Cyp2e1;
   Dysbiosis
ID MESSENGER-RNA EXPRESSION; CLOCK GENE-EXPRESSION; INDUCED LIVER-INJURY;
   SHIFT WORK; INTESTINAL PERMEABILITY; ETHANOL INTAKE; POSSIBLE MECHANISM;
   METABOLIC SYNDROME; SLEEP DURATION; SOCIAL JETLAG
AB The circadian clock establishes rhythms throughout the body with an approximately 24 hour period that affect expression of hundreds of genes. Epidemiological data reveal chronic circadian misalignment, common in our society, significantly increases the risk for a myriad of diseases, including cardiovascular disease, diabetes, cancer, infertility and gastrointestinal disease. Disruption of intestinal barrier function, also known as gut leakiness, is especially important in alcoholic liver disease (ALD). Several studies have shown that alcohol causes ALD in only a 20-30% subset of alcoholics. Thus, a better understanding is needed of why only a subset of alcoholics develops ALD. Compelling evidence shows that increased gut leakiness to microbial products and especially LPS play a critical role in the pathogenesis of ALD. Clock and other circadian clock genes have been shown to regulate lipid transport, motility and other gut functions. We hypothesized that one possible mechanism for alcohol-induced intestinal hyperpermeability is through disruption of central or peripheral (intestinal) circadian regulation. In support of this hypothesis, our recent data shows that disruption of circadian rhythms makes the gut more susceptible to injury. Our in vitro data show that alcohol stimulates increased Clock and Per2 circadian clock proteins and that siRNA knockdown of these proteins prevents alcohol-induced permeability. We also show that intestinal Cyp2e1 -mediated oxidative stress is required for alcohol-induced upregulation of Clock and Per2 and intestinal hyperpermeability. Our mouse model of chronic alcohol feeding shows that circadian disruption through genetics (in Clock 19 mice) or environmental disruption by weekly 12h phase shifting results in gut leakiness alone and exacerbates alcohol-induced gut leakiness and liver pathology. Our data in human alcoholics show they exhibit abnormal melatonin profiles characteristic of circadian disruption. Taken together our data support circadian mechanisms for alcohol-induced gut leakiness that could provide new therapeutic targets for ALD. (C) 2015 Elsevier Inc. All rights reserved.
C1 [Forsyth, Christopher B.; Voigt, Robin M.; Swanson, Garth R.; Keshavarzian, Ali] Rush Univ, Med Ctr, Dept Internal Med, Div Digest Dis & Nutr, Chicago, IL 60612 USA.
   [Forsyth, Christopher B.] Rush Univ, Med Ctr, Dept Biochem, Chicago, IL 60612 USA.
   [Keshavarzian, Ali] Rush Univ, Med Ctr, Dept Pharmacol, Chicago, IL 60612 USA.
   [Keshavarzian, Ali] Rush Univ, Med Ctr, Dept Mol Biophys & Physiol, Chicago, IL 60612 USA.
   Univ Utrecht, Fac Sci, Utrecht Inst Pharmaceut Sci, Div Pharmacol, Utrecht, Netherlands.
   [Burgess, Helen J.] Rush Univ, Med Ctr, Dept Behav Sci, Chicago, IL 60612 USA.
C3 Rush University; Rush University; Rush University; Rush University;
   Utrecht University; Rush University
RP Forsyth, CB (corresponding author), Rush Univ, Med Ctr, 1725 W Harrison,Suite 206, Chicago, IL 60612 USA.
EM christopher_b_forsyth@rush.edu
RI Voigt-Zuwala, Robin/IQV-1690-2023; Keshavarzian, Ali/AFM-1148-2022
FU NIAAA NIH HHS [R01 AA023417, K23 AA019966, R01 AA020216] Funding Source:
   Medline
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NR 127
TC 48
Z9 59
U1 2
U2 41
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0741-8329
EI 1873-6823
J9 ALCOHOL
JI Alcohol
PD JUN
PY 2015
VL 49
IS 4
SI SI
BP 389
EP 398
DI 10.1016/j.alcohol.2014.07.021
PG 10
WC Substance Abuse; Pharmacology & Pharmacy; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Substance Abuse; Pharmacology & Pharmacy; Toxicology
GA CJ8YC
UT WOS:000355788400010
PM 25499101
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Luperini, BCO
   Almeida, DC
   Porto, MP
   Marcondes, JPC
   Prado, RP
   Rasera, I
   Oliveira, MRM
   Salvadori, DMF
AF Luperini, B. C. O.
   Almeida, D. C.
   Porto, M. P.
   Marcondes, J. P. C.
   Prado, R. P.
   Rasera, I.
   Oliveira, M. R. M.
   Salvadori, D. M. F.
TI Gene polymorphisms and increased DNA damage in morbidly obese women
SO MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
LA English
DT Article; Proceedings Paper
CT 11th International Conference on Environmental Mutagens
CY NOV 03-08, 2013
CL Foz do Iguassu, BRAZIL
DE Morbidly obese women; Gene polymorphisms; DNA damage; Systemic
   inflammation
ID FTO GENE; FAT MASS; OXIDATIVE STRESS; METABOLIC SYNDROME; CHILDHOOD
   OBESITY; ADIPOSE-TISSUE; LEPTIN GENE; ASSOCIATION; VARIANT; INFLAMMATION
AB Obesity is characterized by increased adipose tissue mass resulting from a chronic imbalance between energy intake and expenditure. Furthermore, there is a clearly defined relationship among fat mass expansion, chronic low-grade systemic inflammation and reactive oxygen species (ROS) generation; leading to ROS-related pathological events. In the past years, genome-wide association studies have generated convincing evidence associating genetic variation at multiple regions of the genome with traits that reflect obesity. Therefore, the present study aimed to evaluate the relationships among the gene polymorphisms ghrelin (GHRL-rs26802), ghrelin receptor (GHSR-rs572169), leptin (LEP-rs7799039), leptin receptor (LEPR-rs1137101) and fat mass and obesity-associated (FTO-rs9939609) and obesity. The relationships among these gene variants and the amount of DNA damage were also investigated. Three hundred Caucasian morbidly obese and 300 eutrophic (controls) women were recruited. In summary, the results demonstrated that the frequencies of the GHRL, GHSR, LEP and LEPR polymorphisms were not different between Brazilian white morbidly obese and eutrophic women. Exceptions were the AA-FTO genotype and allele A, which were significantly more frequent in obese women than in the controls (0.23% vs. 0.10%; 0.46 vs. 0.36, respectively), and the TT-FTO genotype and the T allele, which were less frequent in morbidly obese women (p < 0.01). Furthermore, significant differences in the amount of genetic lesions associated with FTO variants were observed only in obese women. In conclusion, this study demonstrated that the analyzed SNPs were not closely associated with morbid obesity, suggesting they are not the major contributors to obesity. Therefore, our data indicated that these gene variants are not good biomarkers for predicting risk susceptibility for obesity, whereas ROS generated by the inflammatory status might be one of the causes of DNA damage in obese women, favoring genetically related diseases as obesity comorbidities. (C) 2015 Elsevier B.V. All rights reserved.
C1 [Luperini, B. C. O.; Almeida, D. C.; Porto, M. P.; Marcondes, J. P. C.; Prado, R. P.; Salvadori, D. M. F.] UNESP, Botucatu Med Sch, Araraquara, SP, Brazil.
   [Oliveira, M. R. M.] UNESP, Biosci Inst, Araraquara, SP, Brazil.
   [Rasera, I.] Ctr Gastroenterol & Surg Obes, Piracicaba, SP, Brazil.
C3 Universidade Estadual Paulista; Universidade Estadual Paulista
RP Salvadori, DMF (corresponding author), UNESP, Botucatu Med Sch, Araraquara, SP, Brazil.
EM dfavero@fmb.unesp.br
RI Rasera Jr, Irineu/A-9533-2012; Porto, Marianna/N-2948-2013; de Oliveira,
   Maria/AAV-4670-2021; Almeida, Davidson/MSZ-9403-2025; Marcondes, Joao
   Paulo/G-6980-2012; FAVERO SALVADORI, DAISY MARIA/E-7744-2012
OI Marcondes, Joao Paulo/0000-0002-5116-2494; FAVERO SALVADORI, DAISY
   MARIA/0000-0001-9323-3134
FU Sao Paulo Research Foundation (FAPESP); National Council for
   Technological and Scientific Development (CNPq); Federal Agency for the
   Support and Evaluation of Graduate Education of Brazil (CAPES)
FX This study was financially supported by the Sao Paulo Research
   Foundation (FAPESP), the National Council for Technological and
   Scientific Development (CNPq) and the Federal Agency for the Support and
   Evaluation of Graduate Education of Brazil (CAPES).
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NR 60
TC 21
Z9 23
U1 0
U2 30
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0027-5107
EI 1873-135X
J9 MUTAT RES-FUND MOL M
JI Mutat. Res.-Fundam. Mol. Mech. Mutagen.
PD JUN
PY 2015
VL 776
SI SI
BP 111
EP 117
DI 10.1016/j.mrfmmm.2015.01.004
PG 7
WC Biotechnology & Applied Microbiology; Genetics & Heredity; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Biotechnology & Applied Microbiology; Genetics & Heredity; Toxicology
GA CL1WP
UT WOS:000356735900012
PM 26255942
DA 2025-06-11
ER

PT J
AU Bacanu, EV
   Lixandru, D
   Serafinceanu, C
AF Bacanu, E. V.
   Lixandru, D.
   Serafinceanu, C.
TI THE ASSOCIATION BETWEEN ADIPOKINES, INSULIN RESISTANCE MARKERS AND
   MICROALBUMINURIA IN OBESE TYPE 2 DIABETIC PATIENTS
SO ACTA ENDOCRINOLOGICA-BUCHAREST
LA English
DT Article
DE diabetes; obesity; adipokines; microalbuminuria
ID ADIPOSE-TISSUE; METABOLIC SYNDROME; ADIPONECTIN; INFLAMMATION; LEPTIN;
   HYPERLEPTINEMIA; DYSFUNCTION
AB Background. Adipose tissue is linked to cardiovascular and metabolic complications of diabetes by increased local production of adipokines that may lead to oxidative stress and endothelial dysfunction.
   Objective. The aim of the present study was to investigate the association between plasma adipokines levels and anthropometric and systemic endothelial dysfunction markers in obese type 2 diabetic patients.
   Materials and methods. Two groups of type 2 diabetic patients were selected considering their Body Mass Index (BMI) value: group 1, overweight (BMI=28.4-29.9 kg/m(2); n = 35) and group 2, obese (>= 30 BMI <= 40 kg/m(2); n = 45). In all patients there were assessed: height, weight, waist and hip circumference, visceral fat index, albumin/creatinine ratio (ACR), plasma levels of insulin, proinsulin, aliponectin and leptin. The HOMA-IR and waist to hip ratio (WHR)were calculated as well.
   Results. Comparing the obese diabetic patients with the overweight ones, plasma levels of leptin were higher (p<0.001) while adiponectin levels were lower (p<0.05). BMI was positively correlated with leptin (r=0.661, p<0.001) and negatively with adiponectin (r=-0.338, p=0.008). Moreover, leptin was positively correlated with the waist circumference (r=0.453, p<0.001), visceral fat index (r=0.555, p<0.001) and HOMA-IR (r=0.370, p=0.004) while adiponectin was negatively correlated with waist circumference (r=-0.350, p=0.006), visceral fat index (r=-0.269, p=0.038) and HOMA-IR (r=-0.318, p=0.013). We have also found positive correlation for ACR with HbAlc (r=0.549, p<0.001), glycemia (r=-0.411, p=0.001), HOMA-IR (r=0.445, p<0.001) and with leptin (r=0.276, p=0.033) and negative correlation with HDL-cholesterol (r=-0.304, p=0.018).
   Conclusions. Leptin and adiponectin, as indicators of chronic low grade inflammatory syndrome are involved in the pathogenesis of insulin resistance and endothelial dysfunction in obese type 2 diabetic patients.
C1 [Bacanu, E. V.; Serafinceanu, C.] NC Paulescu Natl Inst Diabet Nutr & Metab Dis, Dept Diabet, Bucharest, Romania.
   [Lixandru, D.; Serafinceanu, C.] Carol Davila Univ Med & Pharm, Dept Biochem, Bucharest 050474, Romania.
C3 Carol Davila University of Medicine & Pharmacy
RP Lixandru, D (corresponding author), Carol Davila Univ Med & Pharm, Dept Biochem, 8 Eroilor Sanitari St, Bucharest 050474, Romania.
EM daniela_lixandru@yahoo.com
RI Lixandru, Daniela/U-4330-2017; Serafinceanu, Cristian/AAL-5411-2021
FU European Social Found [POSDRU/89/1.57/S/60746]
FX D. Lixandru acknowledges the postdoctoral program
   POSDRU/89/1.57/S/60746, from European Social Found.
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NR 36
TC 1
Z9 1
U1 0
U2 4
PU EDITURA ACAD ROMANE
PI BUCURESTI
PA CALEA 13 SEPTEMBRIE NR 13, SECTOR 5, BUCURESTI 050711, ROMANIA
SN 1841-0987
EI 1843-066X
J9 ACTA ENDOCRINOL-BUCH
JI Acta Endocrinol.
PD APR-JUN
PY 2014
VL 10
IS 2
BP 228
EP 237
DI 10.4183/aeb.2014.228
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA AF4AQ
UT WOS:000334654200008
DA 2025-06-11
ER

PT J
AU Ding, XB
   Guo, L
   Zhang, Y
   Fan, SJ
   Gu, M
   Lu, Y
   Jiang, D
   Li, YM
   Huang, C
   Zhou, ZQ
AF Ding, Xiaobo
   Guo, Lu
   Zhang, Yu
   Fan, Shengjie
   Gu, Ming
   Lu, Yan
   Jiang, Dong
   Li, Yiming
   Huang, Cheng
   Zhou, Zhiqin
TI Extracts of Pomelo Peels Prevent High-Fat Diet-Induced Metabolic
   Disorders in C57BL/6 Mice through Activating the PPARα and GLUT4 Pathway
SO PLOS ONE
LA English
DT Article
ID MESSENGER-RNA LEVELS; CITRUS FLAVONOIDS; INSULIN-RESISTANCE;
   SERUM-CHOLESTEROL; ENERGY-METABOLISM; OXIDATIVE STRESS; NARINGIN;
   OBESITY; ANTIOBESITY; ANTIOXIDANT
AB Objective: Metabolic syndrome is a serious health problem in both developed and developing countries. The present study investigated the anti-metabolic disorder effects of different pomelo varieties on obese C57BL/6 mice induced by high-fat (HF) diet.
   Design: The peels of four pomelo varieties were extracted with ethanol and the total phenols and flavonoids content of these extracts were measured. For the animal experiment, the female C57BL/6 mice were fed with a Chow diet or a HF diet alone or supplemented with 1% (w/w) different pomelo peel extracts for 8 weeks. Body weight and food intake were measured every other day. At the end of the treatment, the fasting blood glucose, glucose tolerance and insulin (INS) tolerance test, serum lipid profile and insulin levels, and liver lipid contents were analyzed. The gene expression analysis was performed with a quantitative real-time PCR assay.
   Result: The present study showed that the Citrus grandis liangpinyou (LP) and beibeiyou (BB) extracts were more potent in anti-metabolic disorder effects than the duanshiyou (DS) and wubuyou (WB) extracts. Both LP and BB extracts blocked the body weight gain, lowered fasting blood glucose, serum TC, liver lipid levels, and improved glucose tolerance and insulin resistance, and lowered serum insulin levels in HF diet-fed mice. Compared with the HF group, LP and BB peel extracts increased the mRNA expression of PPAR alpha and its target genes, such as FAS, PGC-1 alpha and PGC-1 beta, and GLUT4 in the liver and white adipocyte tissue (WAT).
   Conclusion: We found that that pomelo peel extracts could prevent high-fat diet-induced metabolic disorders in C57BL/6 mice through the activation of the PPAR alpha and GLUT4 signaling. Our results indicate that pomelo peels could be used as a dietary therapy and the potential source of drug for metabolic disorders.
C1 [Ding, Xiaobo; Guo, Lu; Zhang, Yu; Fan, Shengjie; Gu, Ming; Lu, Yan; Li, Yiming; Huang, Cheng] Shanghai Univ Tradit Chinese Med, Sch Pharm, Shanghai, Peoples R China.
   [Ding, Xiaobo; Lu, Yan; Zhou, Zhiqin] Southwest Univ, Coll Hort & Landscape Architecture, Chongqing, Peoples R China.
   [Ding, Xiaobo; Lu, Yan; Zhou, Zhiqin] Minist Educ, Key Lab Hort Sci Southern Mountainous Reg, Chongqing, Peoples R China.
   [Jiang, Dong] Chinese Acad Agr Sci, Citrus Res Inst, Chongqing, Peoples R China.
C3 Shanghai University of Traditional Chinese Medicine; Southwest
   University - China; Ministry of Education - China; Chinese Academy of
   Agricultural Sciences
RP Li, YM (corresponding author), Shanghai Univ Tradit Chinese Med, Sch Pharm, Shanghai, Peoples R China.
EM ymlius@163.com; chuang.shutcm@gmail.com; zzqswu@yahoo.com
RI Guo, Lu/AAZ-7783-2020
OI Guo, Lu/0000-0003-2121-6401
FU National Natural Science Foundation of China [31171930]; Fundamental
   Research Funds for the Central Universities [XDJK2013A014]
FX This research was supported by the the National Natural Science
   Foundation of China (31171930) and the Fundamental Research Funds for
   the Central Universities (XDJK2013A014). All surgery was performed under
   ethyl urethane anesthesia, and all efforts were made to minimize
   suffering. The funders had no role in study design, data collection and
   analysis, decision to publish, or preparation of the manuscript.
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NR 43
TC 55
Z9 60
U1 0
U2 41
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD OCT 16
PY 2013
VL 8
IS 10
AR e77915
DI 10.1371/journal.pone.0077915
PG 9
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 239JR
UT WOS:000326019400142
PM 24147098
OA Green Submitted, gold, Green Published
DA 2025-06-11
ER

PT J
AU Dekker, LH
   Nicolaou, M
   van der A, DL
   Busschers, WB
   Brewster, LM
   Snijder, MB
   Stronks, K
   van Valkengoed, IGM
AF Dekker, Louise H.
   Nicolaou, Mary
   van der A, Daphne L.
   Busschers, Wim B.
   Brewster, Lizzy M.
   Snijder, Marieke B.
   Stronks, Karien
   van Valkengoed, Irene G. M.
TI Sex Differences in the Association Between Serum Ferritin and Fasting
   Glucose in Type 2 Diabetes Among South Asian Surinamese, African
   Surinamese, and Ethnic Dutch The population-based SUNSET study
SO DIABETES CARE
LA English
DT Article
ID BODY IRON STORES; INSULIN-RESISTANCE; TRANSFERRIN SATURATION; METABOLIC
   SYNDROME; OXIDATIVE STRESS; PLASMA FERRITIN; RISK; MEN; WOMEN; ADULTS
AB OBJECTIVE-Moderately elevated iron stores below the levels commonly associated with hemochromatosis have been implicated in the etiology of diabetes. Studies suggest that iron status (measured by serum ferritin) differs significantly according to sex, but inconsistent findings have been reported. Our aim is to test the association between serum ferritin and the prevalence of type 2 diabetes and fasting glucose concentrations in a population-based, multiethnic, cross-sectional study including men and women of African Surinamese, South Asian Surinamese, and ethnic Dutch origin.
   RESEARCH DESIGN AND METHODS-We analyzed data on 508 ethnic Dutch, 597 African Surinamese, and 339 South Asian Surinamese aged 35-60 years. Type 2 diabetes was defined as a fasting plasma glucose level >= 7.0 mmol/L or a self-reported diagnosis.
   RESULTS-Serum ferritin was positively associated with type 2 diabetes and fasting glucose, but differences in the associations according to sex were observed. Serum ferritin concentration was positively associated with type 2 diabetes among women in all ethnic groups (odds ratio [OR] ethnic Dutch: 1.07 [95% CI 1.01-1.13]; OR South Asian Surinamese: 1.05 [1.00-1.10]; OR African Surinamese: 1.05 [1.01-1.10]), but not among men. Serum ferritin was also more strongly associated with fasting glucose in women than in men. Moreover, the magnitude of sex differences in the association between serum ferritin and fasting glucose, but not type 2 diabetes, was more pronounced in the African Surinamese group than in the other ethnic groups (P for interaction <0.0001).
   CONCLUSIONS-We found a positive association between serum ferritin and type 2 diabetes and fasting glucose in our multiethnic population, which appeared stronger among women than men. Further evaluation of the variation in sex differences between ethnic groups is warranted, particularly among the African Surinamese, to understand the mechanisms behind these sex differences. Diabetes Care 36:965-971, 2013
C1 [Dekker, Louise H.; Nicolaou, Mary; Busschers, Wim B.; Snijder, Marieke B.; Stronks, Karien; van Valkengoed, Irene G. M.] Univ Amsterdam, Acad Med Ctr, Dept Publ Hlth, NL-1105 AZ Amsterdam, Netherlands.
   [van der A, Daphne L.] Natl Inst Publ Hlth & Environm, NL-3720 BA Bilthoven, Netherlands.
   [Brewster, Lizzy M.] Univ Amsterdam, Acad Med Ctr, Dept Vasc Med, NL-1105 AZ Amsterdam, Netherlands.
   [Brewster, Lizzy M.] Univ Amsterdam, Acad Med Ctr, Dept Internal Med, NL-1105 AZ Amsterdam, Netherlands.
C3 University of Amsterdam; Academic Medical Center Amsterdam; Netherlands
   National Institute for Public Health & the Environment; University of
   Amsterdam; Academic Medical Center Amsterdam; University of Amsterdam;
   Academic Medical Center Amsterdam
RP Dekker, LH (corresponding author), Univ Amsterdam, Acad Med Ctr, Dept Publ Hlth, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands.
EM l.h.dekker@amc.uva.nl
RI Sonestedt, Emily/I-3814-2016; Shiri, Rahman/ABB-1780-2021; Brewster,
   Lizzy/K-7675-2019; van Valkengoed, Irene/B-2974-2013
OI Stronks, Karien/0000-0002-0921-2232; Brewster, Lizzy
   M/0000-0002-7434-0038; van Valkengoed, Irene/0000-0002-9306-7831;
   Nicolaou, Mary/0000-0002-0419-5816
FU Netherlands Organization for Health Research and Development; Academic
   Medical Centre
FX This study was conducted with support of The Netherlands Organization
   for Health Research and Development and the Academic Medical Centre.
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NR 37
TC 26
Z9 30
U1 0
U2 7
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0149-5992
J9 DIABETES CARE
JI Diabetes Care
PD APR
PY 2013
VL 36
IS 4
BP 965
EP 971
DI 10.2337/dc12-1243
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 110RG
UT WOS:000316462400046
PM 23172974
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Madhira, SL
   Challa, SS
   Chalasani, M
   Nappanveethl, G
   Bhonde, RR
   Ajumeera, R
   Venkatesan, V
AF Madhira, Soundarya L.
   Challa, Satya S.
   Chalasani, Maniprabha
   Nappanveethl, Giridharan
   Bhonde, Ramesh R.
   Ajumeera, Rajanna
   Venkatesan, Vijayalakshmi
TI Promise(s) of Mesenchymal Stem Cells as an In Vitro Model System
   to Depict Pre-Diabetic/Diabetic Milieu in WNIN/GR-Ob Mutant Rats
SO PLOS ONE
LA English
DT Article
ID MUSCLE INSULIN-RESISTANCE; BONE-MARROW; DIABETES-MELLITUS; OXIDATIVE
   STRESS; METABOLIC SYNDROME; LIPID-PEROXIDATION; ANTIOXIDANT STATUS;
   ABDOMINAL OBESITY; STROMAL CELLS; MICROENVIRONMENT
AB Background: Development of model systems have helped to a large extent, in bridging gap to understand the mechanism(s) of disease including diabetes. Interestingly, WNIN/GR-Ob rats (Mutants), established at National Centre for Laboratory Animals (NCLAS) of National Institute of Nutrition (NIN), form a suitable model system to study obesity with Type 2 diabetes (T2D) demonstrating several secondary complications (cataract, cardiovascular complications, infertility, nephropathy etc). The present study has been carried out to explore the potent application(s) of multipotent stem cells such as bone marrow mesenchymal stem cells (BM-MSCs), to portray features of pre-diabetic/T2D vis-a-vis featuring obesity, with impaired glucose tolerance (IGT), hyperinsulinemia (HI) and insulin resistance (IR) seen with Mutant rats akin to human situation.
   Methodology/Principal Findings: Primary cultures of BM-MSCs (third passage) from Mutants, its lean littermate (Lean) and parental control (Control) were characterized for: proliferation markers, disease memory to mark obesity/T2D/HI/IR which included phased gene expression studies for adipogenic/pancreatic lineages, inflammatory markers and differentiation ability to form mature adipocytes/Insulin-like cellular aggregates (ILCAs). The data showed that BM-MSCs from Mutant demonstrated a state of disease memory, depicted by an upregulated expression of inflammatory markers (IL-6, TNF alpha); increased stem cell recruitment (Oct-4, Sox-2) and proliferation rates (CD90+/CD29+, PDA, 'S' phase of cell cycle by FACS and BrdU incorporation); accelerated preadipocyte induction (Dact-1, PPAR gamma 2) with a quantitative increase in mature adipocyte formation (Leptin); ILCAs, which were non-responsive to high glucose did confer the Obese/T2D memory in Mutants. Further, these observations were in compliance with the anthropometric data.
   Conclusions: Given the ease of accessibility and availability of MSCs, the present study form the basis to report for the first time, application of BM-MSCs as a feasible in vitro model system to portray the disease memory of pre-clinical/T2D with IR a major metabolic disorder of global concern.
C1 [Madhira, Soundarya L.; Challa, Satya S.; Chalasani, Maniprabha; Ajumeera, Rajanna; Venkatesan, Vijayalakshmi] Natl Inst Nutr, Dept Biochem Stem Cell Res, Hyderabad 500007, Andhra Pradesh, India.
   [Nappanveethl, Giridharan] Natl Inst Nutr, Natl Ctr Lab Anim Sci, Hyderabad 500007, Andhra Pradesh, India.
   [Bhonde, Ramesh R.] Manipal Inst Regenerat Med, Bangalore, Karnataka, India.
C3 Indian Council of Medical Research (ICMR); ICMR - National Institute of
   Nutrition (NIN); Indian Council of Medical Research (ICMR); ICMR -
   National Animal Resource Facility for Biomedical Research (NARFBR); ICMR
   - National Institute of Nutrition (NIN); Manipal Academy of Higher
   Education (MAHE)
RP Venkatesan, V (corresponding author), Natl Inst Nutr, Dept Biochem Stem Cell Res, Hyderabad 500007, Andhra Pradesh, India.
EM v.venkateshan@gmail.com
RI BHONDE, RAMESH/C-1233-2009
OI Venkatesan, Vijayalakhsmi/0000-0002-3142-9657
FU Department of Biotechnology (DBT) [BT/PR7950/MED/14/1192/2006]
FX National Institue of Nutrition provided the required infrastructure,
   consumables and fellowship towards manpower. This work has been
   supported by Department of Biotechnology
   (DBT)(BT/PR7950/MED/14/1192/2006). The funders had no role in study
   design, data collection and analysis, decision to publish, or
   preparation of the manuscript.
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NR 62
TC 22
Z9 25
U1 1
U2 13
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD OCT 29
PY 2012
VL 7
IS 10
AR e48061
DI 10.1371/journal.pone.0048061
PG 13
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 032HH
UT WOS:000310705300036
PM 23144726
OA gold, Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Meléndez-Oliva, E
   Martínez-Pozas, O
   Sinatti, P
   Carreras-Presas, CM
   Cuenca-Zaldívar, JN
   Turroni, S
   Romero, EAS
AF Melendez-Oliva, Erika
   Martinez-Pozas, Oliver
   Sinatti, Pierluigi
   Martin Carreras-Presas, Carmen
   Cuenca-Zaldivar, Juan Nicolas
   Turroni, Silvia
   Sanchez Romero, Eleuterio A.
TI Relationship Between the Gut Microbiome, Tryptophan-Derived Metabolites,
   and Osteoarthritis-Related Pain: A Systematic Review with Meta-Analysis
SO NUTRIENTS
LA English
DT Review
DE osteoarthritis; gut microbiome; dysbiosis; inflammation; tryptophan
AB Introduction: Osteoarthritis (OA) is the most prevalent form of arthritis and affects over 528 million people worldwide. Degenerative joint disease involves cartilage degradation, subchondral bone remodeling, and synovial inflammation, leading to chronic pain, stiffness, and impaired joint function. Initially regarded as a "wear and tear" condition associated with aging and mechanical stress, OA is now recognized as a multifaceted disease influenced by systemic factors such as metabolic syndrome, obesity, and chronic low-grade inflammation. Recent studies have focused on the gut-joint axis to investigate how the gut microbiome modulates inflammation and pain in OA. Materials and Methods: A systematic review was conducted following the PRISMA guidelines and was registered with PROSPERO (CRD42024556265). This review included studies involving adults with symptomatic OA and analyzed the relationship between the gut microbiome and OA-related pain. Randomized and non-randomized clinical trials, case reports, editorials, and pilot studies were excluded. Searches were performed in PubMed, Cochrane Library, and Web of Science without publication date restrictions, and filtered for "observational studies". The study selection and data extraction were performed by two independent researchers, and the risk of bias was assessed using appropriate tools. Results: Five observational studies were included in the systematic review, and three were included in the meta-analysis. Two studies reported an association between different tryptophan metabolites and pain levels in patients with OA. Two other studies demonstrated a correlation between lipopolysaccharide levels and pain in OA. A fifth study confirmed the relationship between Streptococcus relative abundance of Streptococcus spp. and knee pain. These results were not supported by a meta-analysis, which found no significant association between the presence of pain in OA and the presence of bacilli of the genus Streptococcus or plasma markers of the tryptophan pathway. Conclusions: Current evidence indicates a potential link between gut microbiome dysbiosis and OA-related pain. However, methodological limitations preclude definitive conclusions. Further research using advanced techniques and larger cohorts is needed to validate and extend these findings and elucidate the underlying mechanisms. Targeted manipulation of the gut microbiome may be a valuable strategy for pain management in OA patients.
C1 [Melendez-Oliva, Erika] Univ Alicante, Grp Opt & Visual Percept, Dept Opt Pharmacol & Anat, Alicante, Spain.
   [Melendez-Oliva, Erika; Sanchez Romero, Eleuterio A.] Univ Europea Valencia, Dept Ciencias Salud, Grp Invest Cal Vida & Salud, Alicante 03016, Spain.
   [Melendez-Oliva, Erika; Martinez-Pozas, Oliver; Sanchez Romero, Eleuterio A.] Soc Espanola Disfunc Craneomandibular & Dolor Orof, Physiotherapy & Orofacial Pain Working Grp, Madrid 28009, Spain.
   [Melendez-Oliva, Erika; Martinez-Pozas, Oliver; Sinatti, Pierluigi; Cuenca-Zaldivar, Juan Nicolas; Sanchez Romero, Eleuterio A.] Univ Europea Madrid, Fac Sport Sci, Interdisciplinary Grp Musculoskeletal Disorders, Villaviciosa De Odon 28670, Spain.
   [Martinez-Pozas, Oliver] Univ Rey Juan Carlos, Escuela Int Doctorado, Fac Hlth Sci, Alcorcon 28922, Spain.
   [Sinatti, Pierluigi] IPPOCRATE Ctr Med Specialist, Via La Spezia 38, Rome, Ladispoli, Italy.
   [Martin Carreras-Presas, Carmen] European Univ Madrid, Fac Dent, Oral Med Unit, Special Care Dent Oral Med & Qual Life Res Gorup S, Madrid 28670, Spain.
   [Cuenca-Zaldivar, Juan Nicolas] Univ Alcala, Fac Enfermeria & Fisioterapia, Dept Fisioterapia, Grp Invest Fisioterapia & Dolor, Alcala De Henares 28801, Spain.
   [Cuenca-Zaldivar, Juan Nicolas; Sanchez Romero, Eleuterio A.] Puerta de Hierro Hlth Res Inst Segovia de Arana ID, Res Grp Nursing & Hlth Care, Majadahonda 28222, Spain.
   [Cuenca-Zaldivar, Juan Nicolas] Primary Hlth Care Ctr El Abajon, Phys Therapy Unit, Las Rozas De Madrid 28231, Spain.
   [Turroni, Silvia] Univ Bologna, Dept Pharm & Biotechnol, Unit Microbiome Sci & Biotechnol, Via Belmeloro 6, I-40126 Bologna, Italy.
   [Sanchez Romero, Eleuterio A.] Univ Europea Madrid, Fac Med Hlth & Sports, Dept Physiotherapy, Villaviciosa De Odon 28670, Spain.
C3 Universitat d'Alacant; European University of Madrid; Universidad Rey
   Juan Carlos; European University of Madrid; Universidad de Alcala;
   University of Bologna; European University of Madrid
RP Romero, EAS (corresponding author), Univ Europea Valencia, Dept Ciencias Salud, Grp Invest Cal Vida & Salud, Alicante 03016, Spain.; Martínez-Pozas, O; Romero, EAS (corresponding author), Soc Espanola Disfunc Craneomandibular & Dolor Orof, Physiotherapy & Orofacial Pain Working Grp, Madrid 28009, Spain.; Martínez-Pozas, O; Cuenca-Zaldívar, JN; Romero, EAS (corresponding author), Univ Europea Madrid, Fac Sport Sci, Interdisciplinary Grp Musculoskeletal Disorders, Villaviciosa De Odon 28670, Spain.; Martínez-Pozas, O (corresponding author), Univ Rey Juan Carlos, Escuela Int Doctorado, Fac Hlth Sci, Alcorcon 28922, Spain.; Cuenca-Zaldívar, JN (corresponding author), Univ Alcala, Fac Enfermeria & Fisioterapia, Dept Fisioterapia, Grp Invest Fisioterapia & Dolor, Alcala De Henares 28801, Spain.; Cuenca-Zaldívar, JN; Romero, EAS (corresponding author), Puerta de Hierro Hlth Res Inst Segovia de Arana ID, Res Grp Nursing & Hlth Care, Majadahonda 28222, Spain.; Cuenca-Zaldívar, JN (corresponding author), Primary Hlth Care Ctr El Abajon, Phys Therapy Unit, Las Rozas De Madrid 28231, Spain.; Romero, EAS (corresponding author), Univ Europea Madrid, Fac Med Hlth & Sports, Dept Physiotherapy, Villaviciosa De Odon 28670, Spain.
EM erika.melendez@ua.es; oliver.martp@gmail.com; plgsinatti@gmail.com;
   carmen.martin2@universidadeuropea.es; nicolas.cuenca@salud.madrid.org;
   silvia.turroni@unibo.it; eleuterio.sanchez@universidadeuropea.es
RI MELÉNDEZ-OLIVA, ERIKA/AHC-0860-2022; Martinez, Oliver/LWJ-1968-2024;
   Sinatti, Pierluigi/IWU-5180-2023; Turroni, Silvia/J-7195-2016; Martín
   Carreras-Presas, Carmen/AAF-7303-2021; Sanchez Romero, Eleuterio
   A/AAE-6532-2019
OI MELENDEZ-OLIVA, ERIKA/0000-0001-9366-1614; Sanchez Romero, Eleuterio
   A/0000-0003-0254-6501; Turroni, Silvia/0000-0003-2345-9482; Martinez
   Pozas, Oliver/0000-0003-4804-550X; Cuenca Zaldivar, Juan
   Nicolas/0000-0002-6787-3944; Martin Carreras-Presas,
   Carmen/0000-0002-0937-0994; Sinatti, Pierluigi/0000-0002-3692-5748
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NR 41
TC 2
Z9 2
U1 1
U2 1
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JAN
PY 2025
VL 17
IS 2
AR 264
DI 10.3390/nu17020264
PG 15
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA T3P8F
UT WOS:001404177000001
PM 39861394
OA gold
DA 2025-06-11
ER

PT J
AU Gutiérrez-Cuevas, J
   Lucano-Landeros, S
   López-Cifuentes, D
   Santos, A
   Armendariz-Borunda, J
AF Gutierrez-Cuevas, Jorge
   Lucano-Landeros, Silvia
   Lopez-Cifuentes, Daniel
   Santos, Arturo
   Armendariz-Borunda, Juan
TI Epidemiologic, Genetic, Pathogenic, Metabolic, Epigenetic Aspects
   Involved in NASH-HCC: Current Therapeutic Strategies
SO CANCERS
LA English
DT Review
DE hepatocellular carcinoma; nonalcoholic steatohepatitis; epidemiology;
   genetic and risk factors; pathogenesis; metabolic reprogramming;
   epigenetic alterations; current therapeutic strategies
ID FATTY LIVER-DISEASE; LONG NONCODING RNA; UNRESECTABLE
   HEPATOCELLULAR-CARCINOMA; AMELIORATES HEPATIC STEATOSIS;
   FREE-CHOLESTEROL ACCUMULATION; ALTERED DNA METHYLATION; NONALCOHOLIC
   STEATOHEPATITIS; RISK-FACTORS; INSULIN-RESISTANCE; VITAMIN-E
AB Simple Summary Hepatocellular carcinoma (HCC) is an aggressive human cancer and is caused as consequences of chronic liver diseases. Although HCC is more common in patients with cirrhosis, there is increasing evidence that this cancer may develop in the setting of noncirrhotic nonalcoholic steatohepatitis (NASH), even simple hepatic steatosis may progress to carcinogenesis development. NASH is associated with obesity, hyperlipidemia, insulin resistance, and type 2 diabetes (T2D), which are becoming emerging risk factors for the development of HCC, as well as for cardiovascular disease. In this review, we discuss the current molecular data supporting the link between HCC and NASH, with a focus on metabolic alterations, genetic and epigenetic drivers, including current therapeutic strategies for NASH and HCC prevention and treatment. Hepatocellular carcinoma (HCC) is the most common primary liver cancer and is the sixth most frequent cancer in the world, being the third cause of cancer-related deaths. Nonalcoholic steatohepatitis (NASH) is characterized by fatty infiltration, oxidative stress and necroinflammation of the liver, with or without fibrosis, which can progress to advanced liver fibrosis, cirrhosis and HCC. Obesity, metabolic syndrome, insulin resistance, and diabetes exacerbates the course of NASH, which elevate the risk of HCC. The growing prevalence of obesity are related with increasing incidence of NASH, which may play a growing role in HCC epidemiology worldwide. In addition, HCC initiation and progression is driven by reprogramming of metabolism, which indicates growing appreciation of metabolism in the pathogenesis of this disease. Although no specific preventive pharmacological treatments have recommended for NASH, dietary restriction and exercise are recommended. This review focuses on the molecular connections between HCC and NASH, including genetic and risk factors, highlighting the metabolic reprogramming and aberrant epigenetic alterations in the development of HCC in NASH. Current therapeutic aspects of NASH/HCC are also reviewed.
C1 [Gutierrez-Cuevas, Jorge; Lucano-Landeros, Silvia; Lopez-Cifuentes, Daniel; Armendariz-Borunda, Juan] Univ Guadalajara, Inst Mol Biol Med & Gene Therapy, Dept Mol Biol & Genom, CUCS, Guadalajara 44340, Jalisco, Mexico.
   [Santos, Arturo; Armendariz-Borunda, Juan] Tecnol Monterrey, EMCS, Campus Guadalajara, Zapopan 45201, Jalisco, Mexico.
C3 Universidad de Guadalajara; Tecnologico de Monterrey
RP Gutiérrez-Cuevas, J; Armendariz-Borunda, J (corresponding author), Univ Guadalajara, Inst Mol Biol Med & Gene Therapy, Dept Mol Biol & Genom, CUCS, Guadalajara 44340, Jalisco, Mexico.; Armendariz-Borunda, J (corresponding author), Tecnol Monterrey, EMCS, Campus Guadalajara, Zapopan 45201, Jalisco, Mexico.
EM gutierrezcj05@gmail.com; armdbo@gmail.com
RI Santos, Arturo/GQQ-1431-2022; Armendáriz-Borunda, Juan/AAU-1471-2021
OI Armendariz-Borunda, Juan/0000-0002-7101-9943; Santos,
   Arturo/0000-0003-4640-7263; Gutierrez-Cuevas, Jorge/0000-0003-0276-0428;
   Lopez Cifuentes, Daniel/0000-0001-6741-0846
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NR 374
TC 37
Z9 37
U1 5
U2 50
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2072-6694
J9 CANCERS
JI Cancers
PD JAN
PY 2023
VL 15
IS 1
AR 23
DI 10.3390/cancers15010023
PG 54
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA 7P5GT
UT WOS:000908734500001
PM 36612019
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Chen, XY
   Chen, L
   Lin, G
   Wang, ZJ
   Kodali, MC
   Li, MQ
   Chen, HM
   Lebovitz, SG
   Ortyl, TC
   Li, LX
   Ismael, S
   Singh, P
   Malik, KU
   Ishrat, T
   Zhou, FM
   Zheng, W
   Liao, FF
AF Chen, Xingyong
   Chen, Ling
   Lin, Geng
   Wang, Zhengjun
   Kodali, Mahesh C.
   Li, Mingqi
   Chen, Huimin
   Lebovitz, Sarah G.
   Ortyl, Tyler C.
   Li, Lexiao
   Ismael, Saifudeen
   Singh, Purnima
   Malik, Kafait U.
   Ishrat, Tauheed
   Zhou, Fu-Ming
   Zheng, Wei
   Liao, Francesca-Fang
TI White matter damage as a consequence of vascular dysfunction in a
   spontaneous mouse model of chronic mild chronic hypoperfusion with eNOS
   deficiency
SO MOLECULAR PSYCHIATRY
LA English
DT Article
ID MYELIN BASIC-PROTEIN; CEREBRAL-BLOOD-FLOW; NITRIC-OXIDE; COGNITIVE
   IMPAIRMENT; ALZHEIMERS-DISEASE; METABOLIC SYNDROME; PYRAMIDAL NEURONS;
   RISK-FACTORS; DEMENTIA; HYPERTENSION
AB Vascular cognitive impairment and dementia (VCID) is the second most common form of dementia after Alzheimer's disease (AD). Currently, the mechanistic insights into the evolution and progression of VCID remain elusive. White matter change represents an invariant feature. Compelling clinical neuroimaging and pathological evidence suggest a link between white matter changes and neurodegeneration. Our prior study detected hypoperfused lesions in mice with partial deficiency of endothelial nitric oxide (eNOS) at very young age, precisely matching to those hypoperfused areas identified in preclinical AD patients. White matter tracts are particularly susceptible to the vascular damage induced by chronic hypoperfusion. Using immunohistochemistry, we detected severe demyelination in the middle-aged eNOS-deficient mice. The demyelinated areas were confined to cortical and subcortical areas including the corpus callosum and hippocampus. The intensity of demyelination correlated with behavioral deficits of gait and associative recognition memory performances. By Evans blue angiography, we detected blood-brain barrier (BBB) leakage as another early pathological change affecting frontal and parietal cortex in eNOS-deficient mice. Sodium nitrate fortified drinking water provided to young and middle-aged eNOS-deficient mice completely prevented non-perfusion, BBB leakage, and white matter pathology, indicating that impaired endothelium-derived NO signaling may have caused these pathological events. Furthermore, genome-wide transcriptomic analysis revealed altered gene clusters most related to mitochondrial respiratory pathways selectively in the white matter of young eNOS-deficient mice. Using eNOS-deficient mice, we identified BBB breakdown and hypoperfusion as the two earliest pathological events, resulting from insufficient vascular NO signaling. We speculate that the compromised BBB and mild chronic hypoperfusion trigger vascular damage, along with oxidative stress and astrogliosis, accounting for the white matter pathological changes in the eNOS-deficient mouse model. We conclude that eNOS-deficient mice represent an ideal spontaneous evolving model for studying the earliest events leading to white matter changes, which will be instrumental to future therapeutic testing of drug candidates and for targeting novel/specific vascular mechanisms contributing to VCID and AD.
C1 [Chen, Xingyong; Lin, Geng; Wang, Zhengjun; Kodali, Mahesh C.; Li, Mingqi; Chen, Huimin; Lebovitz, Sarah G.; Ortyl, Tyler C.; Singh, Purnima; Malik, Kafait U.; Zhou, Fu-Ming; Zheng, Wei; Liao, Francesca-Fang] Univ Tennessee, Coll Med, Dept Pharmacol Addict Sci Toxicol, Hlth Sci Ctr, Memphis, TN 38163 USA.
   [Chen, Xingyong] Fujian Med Univ, Fujian Prov Hosp, Dept Neurol, Shengli Clin Med Coll, Fuzhou 350001, Peoples R China.
   [Chen, Ling] Fujian Med Univ, Sch Basic Med Sci, Dept Cell Biol & Genet, Fuzhou 350001, Peoples R China.
   [Lin, Geng] China Med Univ, Teaching Ctr Basic Med Expt, Shenyang 110122, Liaoning, Peoples R China.
   [Li, Lexiao; Ismael, Saifudeen; Ishrat, Tauheed] Univ Tennessee, Coll Med, Dept Anat & Neurobiol, Hlth Sci Ctr, Memphis, TN 38163 USA.
   [Zheng, Wei] China Med Univ, Basic Med Univ, Dept Histol & Embryol, Shenyang 110122, Liaoning, Peoples R China.
C3 University of Tennessee System; University of Tennessee Health Science
   Center; Fujian Medical University; Fujian Provincial Hospital; Fujian
   Medical University; China Medical University; University of Tennessee
   System; University of Tennessee Health Science Center; China Medical
   University
RP Zheng, W; Liao, FF (corresponding author), Univ Tennessee, Coll Med, Dept Pharmacol Addict Sci Toxicol, Hlth Sci Ctr, Memphis, TN 38163 USA.; Zheng, W (corresponding author), China Med Univ, Basic Med Univ, Dept Histol & Embryol, Shenyang 110122, Liaoning, Peoples R China.
EM wzheng@cmu.edu.cn; fliao@uthsc.edu
RI Kodali, Mahesh Chandra/GVU-7043-2022; Singh, Purnima/AAP-9631-2020;
   Ismael, Saifudeen/AAE-1679-2021; wang, zhengjun/AAP-3704-2021; Chen,
   Lingling/JCD-4631-2023; Li, Lexiao/AAD-9166-2022
OI Li, Lexiao/0000-0002-3693-5452; Ortyl, Tyler/0000-0002-7479-4005;
   Kodali, Mahesh Chandra/0000-0001-6023-1060
FU Alzheimer Foundation [ZEN-16-362441]; NIH [RO1 NS097800, R21 AG041934,
   NS091593, R01 AG058467, R01 NS120327]; Joint Funds for the Innovation of
   Science and Technology of Fujian Province, China [2017Y9065]; High-level
   Hospital Foster Grants from Fujian Provincial Hospital, Fujian province,
   China [2020HSJJ07]
FX We specially thank Dr. Lubin Lan, Ms Kadijah Wainwrigh and Ms Sherry E
   Frazier Warford for providing excellent technical support; Drs. David
   Hamilton, Brianne M. Hibl and Samuel Tyler Aycock for general
   consultation on animal welfare. We also thank Dr Xing-Lin Tan (Nanhai
   Hospital of Southern Medical University, China) and Dr. Jon O Lundberg
   (Karolinska Institute, Sweden) for constructive discussion. This work
   was supported in part by Alzheimer Foundation ZEN-16-362441 to FFL, NIH
   grants R21 AG041934, NS091593, R01 AG058467 to FFL, NIH R01 NS120327 to
   FFL and FMZ, NIH grants RO1 NS097800 to TI, Joint Funds for the
   Innovation of Science and Technology of Fujian Province, China
   (2017Y9065) and High-level Hospital Foster Grants from Fujian Provincial
   Hospital, Fujian province, China (2020HSJJ07) to X-YC.
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NR 73
TC 29
Z9 30
U1 3
U2 32
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 1359-4184
EI 1476-5578
J9 MOL PSYCHIATR
JI Mol. Psychiatr.
PD NOV
PY 2022
VL 27
IS 11
BP 4754
EP 4769
DI 10.1038/s41380-022-01701-9
EA AUG 2022
PG 16
WC Biochemistry & Molecular Biology; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Neurosciences & Neurology; Psychiatry
GA 9B2MM
UT WOS:000838488700004
PM 35948662
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Kim, HJ
   Kwon, H
   Yun, JM
   Cho, B
   Park, JH
AF Kim, Hyun-Jin
   Kwon, Hyuktae
   Yun, Jae Moon
   Cho, Belong
   Park, Jin-Ho
TI Interaction between visceral adiposity and ambient air pollution on LDL
   cholesterol level in Korean adults
SO INTERNATIONAL JOURNAL OF OBESITY
LA English
DT Article
ID OXIDATIVE STRESS; METABOLIC SYNDROME; PARTICLE NUMBER; MOUSE MODEL;
   INFLAMMATION; EXPOSURE; TISSUE; LIPIDS; ACCUMULATION; ASSOCIATION
AB Background Although previous reports have found that obesity intensifies the negative impact of long-term air pollution exposure on the low-density lipoprotein-cholesterol (LDL-C) level, few studies have examined whether the type of abdominal adiposity, such as visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT), and the visceral-to-subcutaneous fat ratio (VSR) affects this relationship. We investigated the association between ambient air pollution and LDL-C in Korean adults and identified whether this association is different by the type of abdominal adiposity. Methods A total of 2737 adults were included. Abdominal fat areas were quantified by computed tomography, and the annual average concentration of air pollutants was included in this analysis. Results In the total sample, none of the air pollutants was associated with LDL-C level in either the crude or adjusted model (all p > 0.05). The association was not significant even in subgroups stratified according to the obesity status defined by body mass index, and no interaction on the LDL-C level was also found (all p(int) > 0.05). In the subgroup analysis stratified according to adiposity level, particulate matter with an aerodynamic diameter of <= 10 mu m (PM10) [beta (SE) = 3.58 (1.59); p = 0.0245] and sulfur dioxide (SO2) exposures [beta (SE) = 2.71 (1.27); p = 0.0330] in the high-VAT group were associated with the increased LDL-C level. Interactions on LDL-C level were also found between VAT level and ambient air pollutants such as PM10 and SO2 (both p(int) < 0.05). In the analysis of the VSR, PM10 exposure showed a significant interaction on LDL level (p(int) = 0.0032). However, the strength of these associations was not significant across all SAT subgroup (all p(int) > 0.05). Conclusions In conclusion, we found that association between air pollution exposure and LDL-C level is different by abdominal fat distribution.
C1 [Kim, Hyun-Jin] Natl Canc Ctr, Natl Canc Control Inst, Goyang 10408, South Korea.
   [Kwon, Hyuktae; Yun, Jae Moon; Cho, Belong; Park, Jin-Ho] Seoul Natl Univ Hosp, Dept Family Med, Seoul 03080, South Korea.
   [Cho, Belong; Park, Jin-Ho] Seoul Natl Univ, Coll Med, Dept Family Med, Seoul 03080, South Korea.
C3 National Cancer Center - Korea (NCC); Seoul National University (SNU);
   Seoul National University Hospital; Seoul National University (SNU)
RP Park, JH (corresponding author), Seoul Natl Univ Hosp, Dept Family Med, Seoul 03080, South Korea.; Park, JH (corresponding author), Seoul Natl Univ, Coll Med, Dept Family Med, Seoul 03080, South Korea.
EM pjhn@snu.ac.kr
RI Kwon, Hyuktae/C-4286-2013; Kim, So-Young/JFS-7698-2023; Cho,
   Belong/GLU-3443-2022; Jin-Ho, Park/J-6962-2019
OI Kwon, Hyuktae/0000-0002-0312-3650
FU Basic Science Research Program through the National Research Foundation
   of Korea - Ministry of Education, Science and Technology
   [2018R1D1A1A09083190]
FX This research was supported by the Basic Science Research Program
   through the National Research Foundation of Korea funded by the Ministry
   of Education, Science and Technology (Grant no. 2018R1D1A1A09083190).
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NR 35
TC 8
Z9 8
U1 0
U2 3
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0307-0565
EI 1476-5497
J9 INT J OBESITY
JI Int. J. Obes.
PD MAR
PY 2021
VL 45
IS 3
BP 547
EP 554
DI 10.1038/s41366-020-00714-0
EA NOV 2020
PG 8
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA QM5WD
UT WOS:000590459900001
PM 33203924
DA 2025-06-11
ER

PT J
AU Haghighatdoost, F
   Bellissimo, N
   de Zepetnek, JOT
   Rouhani, MH
AF Haghighatdoost, Fahimeh
   Bellissimo, Nick
   de Zepetnek, Julia O. Totosy
   Rouhani, Mohammad Hossein
TI Association of vegetarian diet with inflammatory biomarkers: a
   systematic review and meta-analysis of observational studies
SO PUBLIC HEALTH NUTRITION
LA English
DT Review
DE Vegetarianism; Omnivores; Inflammation; C-reactive protein; IL-6
ID C-REACTIVE PROTEIN; SOY LEGUME CONSUMPTION; INTIMA-MEDIA THICKNESS;
   RISK-FACTORS; CARDIOVASCULAR-DISEASE; OXIDATIVE STRESS; VEGETABLE
   CONSUMPTION; VITAMIN-B-12 STATUS; METABOLIC SYNDROME; GUT MICROBIOTA
AB Objective: Vegetarian diets contain various anti-inflammatory components. We aimed to investigate the effects of vegetarianism on inflammatory biomarkers when compared with omnivores.
   Design: Systematic review and meta-analysis.
   Setting: Literature search was conducted in Science Direct, Proquest, MEDLINE and Google Scholar up to June 2016. Summary estimates and corresponding 95 % CI were derived via the DerSimonian and Laird method using random effects, subgroup analyses were run to find the source of heterogeneity and a fixed-effect model examined between-subgroup heterogeneity.
   Subjects: Studies were included if they evaluated effects of any type of vegetarianism compared with omnivores on circulating levels of inflammatory biomarkers. No restriction was made in terms of language or the date of study publications.
   Results: Eighteen articles were included. Pooled effect size showed no difference in high-sensitivity C-reactive protein (hs-CRP) levels in vegetarians v. omnivores (Hedges' g=-0.15; 95 % CI -0.35, 0.05), with high heterogeneity (I-2=75.6 %, P<0.01). A subgroup analysis by minimum duration of vegetarianism showed that a minimum duration of 2 years vegetarianism was associated with lower hs-CRP levels v. omnivores (Hedges' g=-0.29; 95 % CI -0.59, 0.01), with moderate heterogeneity (I-2=68.9 %, P<0.01). No significant effect was found in studies using a minimum duration of 6 months of vegetarianism, with low heterogeneity. Vegetarianism was associated with increased IL-6 concentrations (0.21 pg/ml; 95 % CI 0.18, 0.25), with no heterogeneity (I-2=0.0 %, P=0.60).
   Conclusions: The meta-analysis provides evidence that vegetarianism is associated with lower serum concentrations of hs-CRP when individuals follow a vegetarian diet for at least 2 years. Further research is necessary to draw appropriate conclusions regarding potential associations between vegetarianism and IL-6 levels. A vegetarian diet might be a useful approach to manage inflammaging in the long term.
C1 [Haghighatdoost, Fahimeh; Rouhani, Mohammad Hossein] Isfahan Univ Med Sci, Food Secur Res Ctr, Hezar Jarib St,POB 81745, Esfahan, Iran.
   [Haghighatdoost, Fahimeh; Rouhani, Mohammad Hossein] Isfahan Univ Med Sci, Sch Nutr & Food Sci, Dept Community Nutr, Esfahan, Iran.
   [Bellissimo, Nick; de Zepetnek, Julia O. Totosy] Ryerson Univ, Sch Nutr, Toronto, ON, Canada.
C3 Isfahan University of Medical Sciences; Isfahan University of Medical
   Sciences; Toronto Metropolitan University
RP Rouhani, MH (corresponding author), Isfahan Univ Med Sci, Food Secur Res Ctr, Hezar Jarib St,POB 81745, Esfahan, Iran.; Rouhani, MH (corresponding author), Isfahan Univ Med Sci, Sch Nutr & Food Sci, Dept Community Nutr, Esfahan, Iran.
EM s_m_rouhani2003@yahoo.com
RI Rouhani, Mohammad/H-6937-2019
OI Totosy de Zepetnek, Julia/0000-0001-7011-5143; Bellissimo,
   Nick/0000-0002-6177-3731; Rouhani, Mohammad Hossein/0000-0003-2451-0083
FU Food Security Research Center, Isfahan University of Medical Sciences,
   Isfahan, Iran; School of Nutrition and Food Science, Isfahan University
   of Medical Sciences
FX The study was supported by Food Security Research Center, Isfahan
   University of Medical Sciences, Isfahan, Iran. This paper was supported
   by the School of Nutrition and Food Science, Isfahan University of
   Medical Sciences.
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NR 75
TC 103
Z9 109
U1 0
U2 19
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 1368-9800
EI 1475-2727
J9 PUBLIC HEALTH NUTR
JI Public Health Nutr.
PD OCT
PY 2017
VL 20
IS 15
BP 2713
EP 2721
DI 10.1017/S1368980017001768
PG 9
WC Public, Environmental & Occupational Health; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health; Nutrition & Dietetics
GA FP7SP
UT WOS:000417837700008
PM 28836492
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Li, BH
   He, FP
   Yang, X
   Chen, YW
   Fan, JG
AF Li, Bing-Hang
   He, Fang-Ping
   Yang, Xin
   Chen, Yuan-Wen
   Fan, Jian-Gao
TI Steatosis induced CCL5 contributes to early-stage liver fibrosis in
   nonalcoholic fatty liver disease progress
SO TRANSLATIONAL RESEARCH
LA English
DT Article
ID HEPATIC STELLATE CELLS; I COLLAGEN; INSULIN-RESISTANCE; METABOLIC
   SYNDROME; OXIDATIVE STRESS; CCR5 ANTAGONIST; UP-REGULATION; EXPRESSION;
   STEATOHEPATITIS; PATHOGENESIS
AB The rapidly increasing prevalence of nonalcoholic fatty liver disease (NAFLD) has become one of the major public health threats in China and worldwide. However, during the development of NAFLD, the key mechanism underlying the progression of related fibrosis remains unclear, which greatly impedes the development of optimal NAFLD therapy. In the current study, we were endeavored to characterize a proinflammatory cytokine, CCL5, as a major contributor for fibrosis in NAFLD. The results showed that CCL5 was highly expressed in fatty liver and NASH patients. In NAFLD rats induced by 8-week-HFD, CCL5 and its receptor, CCR5, were significantly up-regulated and liver fibrosis exclusively occurred in this group. In addition, we showed that hepatocytes are the major source contributing to this CCL5 elevation. Interestingly, a CCL5 inhibitor Met-CCL5, significantly decreased liver fibrosis but not hepatic steatosis. Using a cell model of hepatic steatosis, we found that the conditioned medium of lipid -overloaded hepatocytes (Fa2N-4 cells) which produced excessive CCL5 stimulated the profibrotic activities of hepatic stellate cells (LX-2) as manifested by increased migration rate, proliferation and collagen production of LX-2 cells. CCL5 knockdown in Fa2N-4 cells, Met-CCL5 or CCR5 antibody treatment on LX-2 cells all significantly inhibited the conditioned medium of FFA-treated Fa2N-4 cells to exert stimulatory effects on LX-2 cells. Consistently, the conditioned medium of Fa2N-4 cells with CCL5 over-expression significantly enhanced migration rate, cell proliferation and collagen production of LX-2 cells. All these results support that CCL5 produced by steatotic hepatocytes plays an essential role in fibrotic signaling machinery of NAFLD. In addition, we were able to identify C/EBP-beta as the up-stream regulator of CCL5 gene transcription in hepatocytes treated with free fatty acid (FFA). Our data strongly supported that CCL5 plays a pivotal regulatory role in hepatic fibrosis during NAFLD, which constitutes a novel and exciting observation that may call for potential future development of specific CCL5-targeted NAFLD therapy.
C1 [Chen, Yuan-Wen; Fan, Jian-Gao] Shanghai Jiao Tong Univ, Sch Med, Xinhua Hosp, Dept Gastroenterol, 1665 Kongjiang Rd, Shanghai 200092, Peoples R China.
   Xinjiang Med Univ, Affiliated Hosp 1, Dept Hepatol, Urumqi, Peoples R China.
   Univ Alabama, Dept Biol, Tuscaloosa, AL 35487 USA.
C3 Shanghai Jiao Tong University; Xinjiang Medical University; University
   of Alabama System; University of Alabama Tuscaloosa
RP Chen, YW; Fan, JG (corresponding author), Shanghai Jiao Tong Univ, Sch Med, Xinhua Hosp, Dept Gastroenterol, 1665 Kongjiang Rd, Shanghai 200092, Peoples R China.
EM drchenyuanwen@163.com; fattyliver2004@126.com
RI Chen, Yuanwen/AAL-6421-2020
OI Chen, Yuanwen/0000-0003-4210-007X
FU National Natural Science Foundation of China [81170410, 81360138]; New
   Talented Young Medical Specialist Cultivating Program of Shanghai
   [XYQ2011010]; State Key Development Program for Basic Research of China
   [2012CB517501]
FX This work was supported by Grants No. 81170410 (for Y.C.), No. 81360138
   (for F.H.) from the National Natural Science Foundation of China and
   sponsored by New Talented Young Medical Specialist Cultivating Program
   of Shanghai No. XYQ2011010 (for Y.C.), and by the State Key Development
   Program for Basic Research of China No. 2012CB517501 (for J.F.).
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NR 63
TC 51
Z9 55
U1 1
U2 21
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1931-5244
EI 1878-1810
J9 TRANSL RES
JI Transl. Res.
PD FEB
PY 2017
VL 180
BP 103
EP 117
DI 10.1016/j.trsl.2016.08.006
PG 15
WC Medical Laboratory Technology; Medicine, General & Internal; Medicine,
   Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology; General & Internal Medicine; Research &
   Experimental Medicine
GA EJ5KI
UT WOS:000393256500009
PM 27639593
DA 2025-06-11
ER

PT J
AU Bounihi, A
   Bitam, A
   Bouazza, A
   Yargui, L
   Koceir, EA
AF Bounihi, Abdenour
   Bitam, Arezki
   Bouazza, Asma
   Yargui, Lyece
   Koceir, Elhadj Ahmed
TI Fruit vinegars attenuate cardiac injury via anti-inflammatory and
   anti-adiposity actions in high-fat diet-induced obese rats
SO PHARMACEUTICAL BIOLOGY
LA English
DT Article
DE Visceral fat obesity; inflammation; adipokine; heart; prickly pear;
   apple; pomegranate
ID C-REACTIVE PROTEIN; OXIDATIVE STRESS; TNF-ALPHA; BODY-FAT; METABOLIC
   SYNDROME; LIPID PROFILE; INFLAMMATION; ADIPOKINES; LEPTIN; WEIGHT
AB Context: Fruit vinegars (FVs) are used in Mediterranean folk medicine for their hypolipidemic and weigh-treducing properties.
   Objective: To investigate the preventive effects of three types of FV, commonly available in Algeria, namely prickly pear [Opuntia ficus-indica (L.) Mill (Cectaceae)], pomegranate [Punica granatum L. (Punicaceae)], and apple [Malus domestica Borkh. (Rosaceae)], against obesity-induced cardiomyopathy and its underlying mechanisms.
   Materials and methods: Seventy-two male Wistar rats were equally divided into 12 groups. The first group served as normal control (distilled water, 7 mL/kg bw), and the remaining groups were respectively treated with distilled water (7 mL/kg bw), acetic acid (0.5% w/v, 7 mL/kg bw) and vinegars of pomegranate, apple or prickly pear (at doses of 3.5, 7 and 14 mL/kg bw, acetic acid content as mentioned above) along with a high-fat diet (HFD). The effects of the oral administration of FV for 18 weeks on the body and visceral adipose tissue (VAT) weights, plasma inflammatory and cardiac enzymes biomarkers, and in heart tissue were evaluated.
   Results: Vinegars treatments significantly (p < .05) attenuated the HFD-induced increase in bw (0.2-0.5-fold) and VAT mass (0.7-1.8-fold), as well as increase in plasma levels of CRP (0.1-0.3-fold), fibrinogen (0.2-0.3-fold), leptin (1.7-3.7-fold), TNF-alpha (0.1-0.6-fold), AST (0.9-1.4-fold), CK-MB (0.3-1.4-fold) and LDH (2.7-6.7-fold). Moreover, vinegar treatments preserved myocardial architecture and attenuated cardiac fibrosis.
   Discussion and conclusion: These findings suggest that pomegranate, apple and prickly pear vinegars may prevent HFD-induced obesity and obesity-related cardiac complications, and that this prevention may result from the potent anti-inflammatory and anti-adiposity properties of these vinegars.
C1 [Bounihi, Abdenour; Bitam, Arezki; Bouazza, Asma; Koceir, Elhadj Ahmed] USTHB, FSB, Dept Biol & Physiol Organisms, Bioenerget & Intermediary Metab Team, Algiers, Algeria.
   [Bitam, Arezki] Ecole Natl Super Agron, Dept Food Technol & Human Nutr, Algiers, Algeria.
   [Yargui, Lyece] Mustapha Bacha Hosp, Fac Hlth Sci, Dept Med, Cent Biochem Lab, Algiers, Algeria.
C3 University Science & Technology Houari Boumediene; Ecole Nationale
   Polytechnique - Algeria
RP Bounihi, A (corresponding author), USTHB, FSB, Dept Biol & Physiol Organisms, Bioenerget & Intermediary Metab Team, Algiers, Algeria.
EM abounihi@gmail.com
RI Bounihi, Abdenour/ABF-7589-2021
OI KOCEIR, Elhadj-Ahmed/0000-0003-1345-2535; BOUNIHI,
   Abdenour/0000-0001-7794-418X
FU Algerian Agency for the Research & Development in Health [PNR] from the
   National Administration of Algerian Higher Education and Scientific
   Research (DGRSDT) [208/ANDRS/2011, 41/ANDRS/2011]
FX The study was supported, in part, by the Algerian Agency for the
   Research & Development in Health [PNR nos. 208/ANDRS/2011 and
   41/ANDRS/2011] from the National Administration of Algerian Higher
   Education and Scientific Research (DGRSDT).
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NR 83
TC 33
Z9 37
U1 0
U2 25
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1388-0209
EI 1744-5116
J9 PHARM BIOL
JI Pharm. Biol.
PY 2017
VL 55
IS 1
BP 43
EP 52
DI 10.1080/13880209.2016.1226369
PG 10
WC Plant Sciences; Medical Laboratory Technology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Medical Laboratory Technology; Pharmacology & Pharmacy
GA EG2BE
UT WOS:000390846600049
PM 27595296
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Ishii, Y
   Motohashi, Y
   Muramatsu, M
   Katsuda, Y
   Miyajima, K
   Sasase, T
   Yamada, T
   Matsui, T
   Kume, S
   Ohta, T
AF Ishii, Yukihito
   Motohashi, Yu
   Muramatsu, Makoto
   Katsuda, Yoshiaki
   Miyajima, Katsuhiro
   Sasase, Tomohiko
   Yamada, Takahisa
   Matsui, Tohru
   Kume, Shinichi
   Ohta, Takeshi
TI Female spontaneously diabetic Torii fatty rats develop nonalcoholic
   steatohepatitis-like hepatic lesions
SO WORLD JOURNAL OF GASTROENTEROLOGY
LA English
DT Article
DE Nonalcoholic steatohepatitis; Spontaneously diabetic Torii fatty rat;
   Fibrosis; Fatty liver; Metabolic syndrome
ID LIVER-DISEASE; HEPATOCELLULAR-CARCINOMA; CYTOCHROME-P450 2E1;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; ADIPOSE-TISSUE; DB/DB MICE; MODEL;
   DIET; STEATOSIS
AB AIM: To investigate the histological features of the liver in spontaneously diabetic Torii (SDT) fatty rats compared with age-matched Sprague-Dawley (SD) rats.
   METHODS: Female SDT Lepr fa (SDT fatty) rats and age-matched SD rats were fed ad libitum. Body weight and biochemical parameters, such as serum glucose, triglyceride (TG), total cholesterol (TC), alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels as well as fatty acid and TG accumulation in the liver were evaluated at 8 wk of age in the nonfasting state and at 8-wk intervals from 8 to 40 wk of age. Histopathological examinations of the liver were performed using hematoxylin and eosin and Sirius Red staining as well as double staining for ED-1 and toluidine blue. The expression of genes involved in TG synthesis, inflammation, and fibrosis was examined in the liver.
   RESULTS: SDT fatty rats showed significantly increased body weight compared with SD rats. Serum glucose, TG, and TC levels were significantly higher in SDT fatty rats compared with SD rats. The serum AST and ALT levels in SDT fatty rats were significantly elevated at 8 wk of age compared with the levels in SD rats. Hepatic TG content was marked in SDT fatty rats from 8 to 32 wk of age. Histopathologically, severe hepatosteatosis accompanied by inflammation was observed at 8 wk of age, and fibrosis started to occur at 32 wk of age. Furthermore, Sirius Red and ED-1 staining were increased in the liver at 32 wk of age. Hepatic gene expression related to TG synthesis, inflammation and fibrosis tended to increase in SDT fatty rats compared with SD rats, and the gene expression related to TG secretion was decreased in SDT fatty rats compared with SD rats.
   CONCLUSION: Female SDT fatty rats have the potential to become an important animal model of nonalcoholic steatohepatitis with type 2 diabetes and obesity.
C1 [Ishii, Yukihito; Muramatsu, Makoto; Katsuda, Yoshiaki; Sasase, Tomohiko; Ohta, Takeshi] Japan Tobacco Inc, Cent Pharmaceut Res Inst, Osaka 5691125, Japan.
   [Miyajima, Katsuhiro] Japan Tobacco Inc, Cent Pharmaceut Res Inst, Toxicol Res Labs, Hadano, Kanagawa 2570024, Japan.
   [Yamada, Takahisa] Niigata Univ, Grad Sch Sci & Technol, Nishi Ku, Niigata 9502181, Japan.
   [Matsui, Tohru; Kume, Shinichi] Kyoto Univ, Grad Sch Agr, Sakyo Ku, Kyoto 6068502, Japan.
C3 Japan Tobacco Inc.; Japan Tobacco Inc.; Niigata University; Kyoto
   University
RP Ishii, Y (corresponding author), Japan Tobacco Inc, Cent Pharmaceut Res Inst, 1-1 Murasaki Cho, Takatsuki, Osaka 5691125, Japan.
EM yukihito.ishii@jt.com
OI tai tian, yi/0000-0002-9573-3455
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NR 37
TC 10
Z9 10
U1 0
U2 7
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 8226 REGENCY DR, PLEASANTON, CA 94588 USA
SN 1007-9327
EI 2219-2840
J9 WORLD J GASTROENTERO
JI World J. Gastroenterol.
PD AUG 14
PY 2015
VL 21
IS 30
BP 9067
EP 9078
DI 10.3748/wjg.v21.i30.9067
PG 12
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA CS6ZS
UT WOS:000362233700007
PM 26290633
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Seneff, S
   Davidson, RM
   Lauritzen, A
   Samsel, A
   Wainwright, G
AF Seneff, Stephanie
   Davidson, Robert M.
   Lauritzen, Ann
   Samsel, Anthony
   Wainwright, Glyn
TI A novel hypothesis for atherosclerosis as a cholesterol sulfate
   deficiency syndrome
SO THEORETICAL BIOLOGY AND MEDICAL MODELLING
LA English
DT Article
ID GAMMA-GLUTAMYL-TRANSFERASE; NITRIC-OXIDE SYNTHASE;
   CORONARY-HEART-DISEASE; CARDIOVASCULAR RISK-FACTORS; HYDROGEN-SULFIDE;
   HEPARAN-SULFATE; ENDOTHELIAL GLYCOCALYX; METABOLIC SYNDROME; OXIDATIVE
   STRESS; LIPID-METABOLISM
AB Background: Despite a vast literature, atherosclerosis and the associated ischemia/reperfusion injuries remain today in many ways a mystery. Why do atheromatous plaques make and store a supply of cholesterol and sulfate within the major arteries supplying the heart? Why are treatment programs aimed to suppress certain myocardial infarction risk factors, such as elevated serum homocysteine and inflammation, generally counterproductive?
   Methods: Our methods are based on an extensive search of the literature in atherosclerotic cardiovascular disease as well as in the area of the unique properties of water, the role of biosulfates in the vascular wall, and the role of electromagnetic fields in vascular flow. Our investigation reveals a novel pathology linked to atherosclerosis that better explains the observed facts than the currently held popular view.
   Results: We propose a novel theory that atherosclerosis can best be explained as being due to cholesterol sulfate deficiency. Furthermore, atheromatous plaques replenish the supply of cholesterol and sulfate to the microvasculature, by exploiting the inflammatory agent superoxide to derive sulfate from homocysteine and other sulfur sources. We argue that the sulfate anions attached to the glycosaminoglycans in the glycocalyx are essential in maintaining the structured water that is crucial for vascular endothelial health and erythrocyte mobility through capillaries. Sulfate depletion leads to cholesterol accumulation in atheromas, because its transport through water-based media depends on sulfurylation. We show that streaming potential induces nitric oxide (NO) release, and NO derivatives break down the extracellular matrix, redistributing sulfate to the microvasculature. We argue that low (less negative) zeta potential due to insufficient sulfate anions leads to hypertension and thrombosis, because these responses can increase streaming potential and induce nitric-oxide mediated vascular relaxation, promoting oxygen delivery. Our hypothesis is a parsimonious explanation of multiple features of atherosclerotic cardiovascular disease.
   Conclusions: If our interpretation is correct, then it would have a significant impact on how atherosclerosis is treated. We recommend a high intake of sulfur-containing foods as well as an avoidance of exposure to toxicants that may impair sulfate synthesis.
C1 [Seneff, Stephanie] MIT, Comp Sci & Artificial Intelligence Lab, Cambridge, MA 02139 USA.
   [Davidson, Robert M.] PhyNet Inc, Internal Med Grp Practice, Longview, TX 75605 USA.
C3 Massachusetts Institute of Technology (MIT)
RP Seneff, S (corresponding author), MIT, Comp Sci & Artificial Intelligence Lab, Cambridge, MA 02139 USA.
EM Seneff@csail.mit.edu
FU Quanta Computers, Taiwan
FX This research is supported in part by Quanta Computers, Taiwan, under
   the auspices of the Qmulus program. Gerald Koenig alerted us to the role
   of GGT in cardiovascular disease.
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NR 154
TC 23
Z9 27
U1 0
U2 21
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1742-4682
J9 THEOR BIOL MED MODEL
JI Theor. Biol. Med. Model.
PD MAY 27
PY 2015
VL 12
AR 9
DI 10.1186/s12976-015-0006-1
PG 24
WC Mathematical & Computational Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Mathematical & Computational Biology
GA CK2KI
UT WOS:000356038800001
PM 26014131
OA hybrid, Green Accepted
DA 2025-06-11
ER

PT J
AU Kraan, TCTMV
   Chen, WJ
   Bunck, MCM
   van Raalte, DH
   van der Zijl, NJ
   van Genugten, RE
   van Bloemendaal, L
   Baggen, JM
   Serné, EH
   Diamant, M
   Horrevoets, AJG
AF Kraan, Tineke C. T. M. van der Pouw
   Chen, Weena J.
   Bunck, Mathijs C. M.
   van Raalte, Daniel H.
   van der Zijl, Nynke J.
   van Genugten, Renate E.
   van Bloemendaal, Liselotte
   Baggen, Josefien M.
   Serne, Erik H.
   Diamant, Michaela
   Horrevoets, Anton J. G.
TI Metabolic changes in type 2 diabetes are reflected in peripheral blood
   cells, revealing aberrant cytotoxicity, a viral signature, and hypoxia
   inducible factor activity
SO BMC MEDICAL GENOMICS
LA English
DT Article
ID GENE-EXPRESSION PROFILES; CARDIOVASCULAR-DISEASE; INSULIN SENSITIVITY;
   ISLET INFLAMMATION; MONONUCLEAR-CELLS; IMMUNE-RESPONSE; MELLITUS;
   INFECTION; MICE; GLUCOSE
AB Background: Metabolic syndrome (MetS) is characterized by central obesity, insulin resistance, dysglycemia, and a pro-atherogenic plasma lipid profile. MetS creates a high risk for development of type 2 diabetes (T2DM) and cardiovascular disease (CVD), presumably by altering inflammatory responses. Presently, it is unknown how the chronic metabolic disturbances in acute hyperglycemia, MetS and T2DM affect the immune activity of peripheral blood cells.
   Methods: We performed genome-wide expression analysis of peripheral blood cells obtained from patients with T2DM (n = 6) and age-, sex-, BMI- and blood pressure-matched obese individuals with MetS (n = 4) and lean healthy normoglycemic controls (n = 3), both under fasting conditions and after controlled induction of acute hyperglycemia during a 70 min hyperglycemic clamp. Differential gene expression during fasting conditions was confirmed by real-time PCR, for which we included additional age-, sex-, BMI-, and blood pressure-matched obese individuals with (n = 4) or without (n = 4) MetS.
   Results: Pathway and Gene ontology analysis applied to baseline expression profiles of peripheral blood cells from MetS and T2DM patients revealed metabolic changes, highly similar to a reoviral infection gene signature in T2DM patients. Transcription factor binding site analysis indicated that increased HIF-1 alpha activity, a transcription factor induced by either hypoxia or oxidative stress, is responsible for this aberrant metabolic profile in peripheral blood cells from T2DM patients. Acute hyperglycemia in healthy controls resulted in reduced expression of cytotoxicity-related genes, representing NK- and CD8(+) cells. In obese controls, MetS and especially T2DM patients, baseline expression of genes involved in cytotoxicity was already low, compared to healthy controls and did not further decrease upon acute hyperglycemia.
   Conclusions: The reduced activity of cytotoxic genes in T2DM is explained by chronic hyperglycemia, but its acute effects are restricted to healthy controls. Genome expression of circulating leukocytes from T2DM patients differs from MetS individuals by a specific reovirus signature. Our data thus suggest a role for suppressed anti-viral capacity in the etiology of diabetes.
C1 [Kraan, Tineke C. T. M. van der Pouw; Baggen, Josefien M.; Horrevoets, Anton J. G.] Vrije Univ Amsterdam, Med Ctr, Dept Mol Cell Biol & Immunol, Amsterdam, Netherlands.
   [Chen, Weena J.; Bunck, Mathijs C. M.; van Raalte, Daniel H.; van der Zijl, Nynke J.; van Genugten, Renate E.; van Bloemendaal, Liselotte; Serne, Erik H.; Diamant, Michaela] Vrije Univ Amsterdam, Med Ctr, Ctr Diabet, Dept Internal Med, Amsterdam, Netherlands.
C3 Vrije Universiteit Amsterdam; Vrije Universiteit Amsterdam
RP Kraan, TCTMV (corresponding author), Vrije Univ Amsterdam, Med Ctr, Dept Mol Cell Biol & Immunol, Amsterdam, Netherlands.
EM t.vanderpouwkraan@vumc.nl
RI Bunck, Mathijs/C-6693-2008
OI van Raalte, Daniel/0000-0003-2894-6124; Serne, Erik/0000-0003-0657-7225
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NR 68
TC 23
Z9 23
U1 0
U2 3
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1755-8794
J9 BMC MED GENOMICS
JI BMC Med. Genomics
PD MAY 9
PY 2015
VL 8
AR 20
DI 10.1186/s12920-015-0096-y
PG 16
WC Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Genetics & Heredity
GA CJ0OE
UT WOS:000355175000001
PM 25956355
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Jones, KW
   Eller, LK
   Parnell, JA
   Doyle-Baker, PK
   Edwards, AL
   Reimer, RA
AF Jones, K. W.
   Eller, L. K.
   Parnell, J. A.
   Doyle-Baker, P. K.
   Edwards, A. L.
   Reimer, R. A.
TI Effect of a dairy- and calcium-rich diet on weight loss and appetite
   during energy restriction in overweight and obese adults: a randomized
   trial
SO EUROPEAN JOURNAL OF CLINICAL NUTRITION
LA English
DT Article
DE calcium; dairy; peptide YY; clinical trial; satiety
ID BODY-WEIGHT; PEPTIDE YY; INFLAMMATORY STRESS; FAT OXIDATION;
   SUPPLEMENTATION; METAANALYSIS; CONSUMPTION; PRODUCTS; HORMONE; WOMEN
AB BACKGROUND/OBJECTIVES: A diet rich in dairy and calcium (Ca) has been variably associated with improvements in body composition and decreased risk of type 2 diabetes. Our objective was to determine if a dietary pattern high in dairy and Ca improves weight loss and subjective appetite to a greater extent than a low dairy/Ca diet during energy restriction in overweight and obese adults with metabolic syndrome.
   SUBJECTS/METHODS: A total of 49 participants were randomized to one of two treatment groups: Control (low dairy, similar to 700mg/day Ca, -500 kcal/day) or Dairy/Ca (high dairy, similar to 1400 mg/day Ca, -500 kcal/day) for 12 weeks. Body composition, subjective ratings of appetite, food intake, plasma satiety hormones, glycemic response and inflammatory cytokines were measured.
   RESULTS: Control (-2.2 +/- 0.5 kg) and Dairy/Ca (-3.3 +/- 0.6 kg) had similar weight loss. Based on self-reported energy intake, the percentage of expected weight loss achieved was higher with Dairy/Ca (82.1 +/- 19.4%) than Control (32.2 +/- 7.7%; P = 0.03). Subjects in the Dairy/Ca group reported feeling more satisfied (P = 0.01) and had lower dietary fat intake (P = 0.02) over 12 weeks compared with Control. Compared with Control, Dairy/Ca had higher plasma levels of peptide tyrosine tyrosine (PYY, P = 0.01) during the meal tolerance test at week 12. Monocyte chemoattractant protein-1 was reduced at 30 min with Dairy/Ca compared with Control (P = 0.04).
   CONCLUSIONS: In conclusion, a dairy-and Ca-rich diet was not associated with greater weight loss than control. Modest increases in plasma PYY concentrations with increased dairy/Ca intake, however, may contribute to enhanced sensations of satisfaction and reduced dietary fat intake during energy restriction. European Journal of Clinical Nutrition (2013) 67, 371-376; doi:10.1038/ejcn.2013.52; published online 6 March 2013
C1 [Jones, K. W.; Doyle-Baker, P. K.; Reimer, R. A.] Univ Calgary, Fac Kinesiol, Calgary, AB T2N 1N4, Canada.
   [Eller, L. K.; Reimer, R. A.] Univ Calgary, Fac Med, Dept Biochem & Mol Biol, Calgary, AB T2N 1N4, Canada.
   [Parnell, J. A.] Mt Royal Univ, Fac Hlth & Community Studies, Dept Phys Educ & Recreat Studies, Calgary, AB, Canada.
   [Edwards, A. L.] Univ Calgary, Dept Med, Fac Med, Calgary, AB T2N 1N4, Canada.
C3 University of Calgary; University of Calgary; Mount Royal University;
   University of Calgary
RP Reimer, RA (corresponding author), Univ Calgary, Fac Kinesiol, 2500 Univ Dr NW, Calgary, AB T2N 1N4, Canada.
EM reimer@ucalgary.ca
RI Doyle-Baker, Patricia/W-7523-2019; Parnell, Jill/AAA-3476-2021
OI Doyle-Baker, Patricia K/0000-0001-9296-8921; Parnell,
   Jill/0000-0002-2936-0558; Reimer, Raylene/0000-0001-5088-7947
FU Dairy Farmers of Canada; Canadian Foundation for Dietetic Research;
   Canadian Institutes of Health Research [MOP 86460]; University of
   Calgary; NSERC; Canadian Diabetes Association
FX RAR previously held research funding from the Dairy Farmers of Canada
   for work distinct from this study. The remaining authors declare no
   conflict of interest.We thank the participants for their role in this
   study and MC Hallam, DT Reid and J Tunnicliffe for assistance on test
   days. Special thanks to the dietitians at the Diabetes, Hypertension and
   Cholesterol Center for help with recruitment. This project has been
   funded in part by research grants from the Canadian Foundation for
   Dietetic Research and Canadian Institutes of Health Research (MOP
   86460). KWJ was supported by an Obesity Training Grant from the
   University of Calgary. LKE was supported by NSERC and Canadian Diabetes
   Association graduate scholarships.
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NR 44
TC 75
Z9 83
U1 0
U2 38
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0954-3007
EI 1476-5640
J9 EUR J CLIN NUTR
JI Eur. J. Clin. Nutr.
PD APR
PY 2013
VL 67
IS 4
BP 371
EP 376
DI 10.1038/ejcn.2013.52
PG 6
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 118PB
UT WOS:000317036600012
PM 23462943
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Ritchie, RH
   Leo, CH
   Qin, CX
   Stephenson, EJ
   Bowden, MA
   Buxton, KD
   Lessard, SJ
   Rivas, DA
   Koch, LG
   Britton, SL
   Hawley, JA
   Woodman, OL
AF Ritchie, Rebecca H.
   Leo, Chen Huei
   Qin, Chengxue
   Stephenson, Erin J.
   Bowden, Marissa A.
   Buxton, Keith D.
   Lessard, Sarah J.
   Rivas, Donato A.
   Koch, Lauren G.
   Britton, Steven L.
   Hawley, John A.
   Woodman, Owen L.
TI Low intrinsic exercise capacity in rats predisposes to age-dependent
   cardiac remodeling independent of macrovascular function
SO AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
LA English
DT Article
DE cardiomyocyte hypertrophy; cardiac fibrosis; insulin resistance; EDHF;
   low-capacity runner; metabolic syndrome; resistance arteries
ID NITRIC-OXIDE SYNTHASE; DIASTOLIC DYSFUNCTION; ARTIFICIAL SELECTION;
   OXIDATIVE STRESS; SKELETAL-MUSCLE; MOUSE MODEL; HYPERPOLARIZING FACTOR;
   SUPEROXIDE GENERATION; MESENTERIC-ARTERIES; NATRIURETIC-PEPTIDE
AB Ritchie RH, Leo CH, Qin C, Stephenson EJ, Bowden MA, Buxton KD, Lessard SJ, Rivas DA, Koch LG, Britton SL, Hawley JA, Woodman OL. Low intrinsic exercise capacity in rats predisposes to age-dependent cardiac remodeling independent of macrovascular function. Am J Physiol Heart Circ Physiol 304: H729-H739, 2013. First published December 21, 2012; doi:10.1152/ajpheart.00638.2012.-Rats selectively bred for low (LCR) or high (HCR) intrinsic running capacity simultaneously present with contrasting risk factors for cardiovascular and metabolic disease. However, the impact of these phenotypes on left ventricular (LV) morphology and microvascular function, and their progression with aging, remains unresolved. We tested the hypothesis that the LCR phenotype induces progressive age-dependent LV remodeling and impairments in microvascular function, glucose utilization, and beta-adrenergic responsiveness, compared with HCR. Hearts and vessels isolated from female LCR (n = 22) or HCR (n = 26) were studied at 12 and 35 wk. Nonselected N:NIH founder rats (11 wk) were also investigated (n = 12). LCR had impaired glucose tolerance and elevated plasma insulin (but not glucose) and body-mass at 12 wk compared with HCR, with early LV remodeling. By 35 wk, LV prohypertrophic and glucose transporter GLUT4 gene expression were up- and downregulated, respectively. No differences in LV beta-adrenoceptor expression or cAMP content between phenotypes were observed. Macrovascular endothelial function was predominantly nitric oxide (NO)-mediated in both phenotypes and remained intact in LCR for both age-groups. In contrast, mesenteric arteries microvascular endothelial function, which was impaired in LCR rats regardless of age. At 35 wk, endothelial-derived hyperpolarizing factor-mediated relaxation was impaired whereas the NO contribution to relaxation is intact. Furthermore, there was reduced beta(2)-adrenoceptor responsiveness in both aorta and mesenteric LCR arteries. In conclusion, diminished intrinsic exercise capacity impairs systemic glucose tolerance and is accompanied by progressive development of LV remodeling. Impaired microvascular perfusion is a likely contributing factor to the cardiac phenotype.
C1 [Ritchie, Rebecca H.; Qin, Chengxue; Bowden, Marissa A.; Buxton, Keith D.] Baker IDI Heart & Diabet Inst, Melbourne, Vic, Australia.
   [Leo, Chen Huei; Stephenson, Erin J.; Lessard, Sarah J.; Rivas, Donato A.; Hawley, John A.; Woodman, Owen L.] RMIT Univ, Sch Med Sci, Bundoora, Vic 3083, Australia.
   [Koch, Lauren G.; Britton, Steven L.] Univ Michigan, Dept Anesthesiol, Ann Arbor, MI 48109 USA.
C3 Baker Heart and Diabetes Institute; Royal Melbourne Institute of
   Technology (RMIT); University of Michigan System; University of Michigan
RP Hawley, JA (corresponding author), RMIT Univ, Sch Med Sci, Exercise Metab Res Grp, Bundoora, Vic 3083, Australia.
EM john.hawley@rmit.edu.au
RI leo, Chen/ABD-2155-2020; Ritchie, Rebecca/E-7392-2011; Woodman,
   Owen/H-7297-2019; Stephenson, Erin/B-5183-2013; Koch,
   Lauren/D-1258-2010; Hawley, John/U-3814-2018; Rivas, Donato/N-6613-2017
OI Woodman, Owen/0000-0003-3759-1396; Qin, Chengxue/0000-0003-2169-2686;
   Hawley, John/0000-0002-0886-9881; Stephenson, Erin/0000-0001-5812-408X;
   Ritchie, Rebecca/0000-0002-8610-0058; Rivas, Donato/0000-0002-4500-6233
FU National Health and Medical Research Council (NHMRC) of Australia
   [ID526638]; National Heart Foundation [G-09M-4348]; Victorian
   Government; NHMRC [ID472673]; National Center for Research Resources
   [R24 RR017718]; Office of Research Infrastructure Programs/OD from the
   National Institutes of Health [ROD012098A]
FX This work was supported by National Health and Medical Research Council
   (NHMRC) of Australia Project Grant ID526638 (to R. H. Ritchie) and
   National Heart Foundation Grant-in-Aid G-09M-4348 (to J. A. Hawley and
   O. L. Woodman) and supported in part by the Victorian Government's
   Operational Infrastructure Support Program. R. H. Ritchie is an NHMRC
   Senior Research Fellow (ID472673). The LCR-HCR rat model system was
   funded by the National Center for Research Resources Grant R24 RR017718
   and is currently supported by the Office of Research Infrastructure
   Programs/OD Grant ROD012098A from the National Institutes of Health.
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NR 51
TC 21
Z9 25
U1 0
U2 26
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0363-6135
EI 1522-1539
J9 AM J PHYSIOL-HEART C
JI Am. J. Physiol.-Heart Circul. Physiol.
PD MAR
PY 2013
VL 304
IS 5
BP H729
EP H739
DI 10.1152/ajpheart.00638.2012
PG 11
WC Cardiac & Cardiovascular Systems; Physiology; Peripheral Vascular
   Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Physiology
GA 100EU
UT WOS:000315679900010
PM 23262135
OA Green Published
DA 2025-06-11
ER

PT J
AU Wu, GH
   Wang, MD
   Du, ZF
   Li, Z
   Han, TT
   Xie, ZW
   Gu, W
AF Wu, Guohuo
   Wang, Mengdi
   Du, Zhaofeng
   Li, Zhuang
   Han, Tingting
   Xie, Zhongwen
   Gu, Wei
TI Tea polyphenol EGCG enhances the improvements of calorie restriction on
   hepatic steatosis and obesity while reducing its adverse outcomes in
   obese rats
SO PHYTOMEDICINE
LA English
DT Article
DE Obesity; Calorie restriction; EGCG; Gut microbiota; Lipidomics
ID METABOLIC SYNDROME; GUT MICROBIOTA; HIGH-FAT; DYSBIOSIS
AB Background: Currently, calorie restriction (CR) is popular among young people as a way to lose weight and prevent obesity. However, CR can also cause a series of side effects, such as weight regain after resuming free eating. Tea polyphenol epigallocatechin-3-gallate (EGCG) has been widely recognized as antiobesity effects. However, whether EGCG can enhance the antiobesity effect of CR and reduce its adverse outcomes is still unclear. Purpose: This study aimed to explore the enhancing effect and molecular mechanism of EGCG supplementation on CR in improving hepatic steatosis and obesity. Methods: The enhancing effect and molecular mechanism of EGCG supplementation on CR in alleviating hepatic steatosis and obesity were explored using a leptin receptor-knockout (LepR KO) rat model by performing biochemical, histochemistry, qPCR, plasma lipidomic, and gut microbiota analysis. Results: Our results showed that CR plus EGCG exhibited enhanced preventive effects in reducing blood glucose, insulin, TC, TG, LDL-C, and FFA levels in plasma, and protection against hepatic steatosis in LepR KO rats than CR alone. In addition, CR plus EGCG remarkably reduced oxidative stress and systemic inflammatory responses in LepR KO rats. Moreover, the combined intervention showed an enhanced improvement effect on the homeostasis of gut microbiota than CR alone, including increasing gut microbiota diversity and modulating microbiota composition. Plasma lipidomics analysis showed that CR plus EGCG significantly improved glycerophospholipid, glycerolipid and sphingolipid metabolism in LepR KO rats. Mechanistic studies showed that CR combined EGCG enhanced SIRT6 and suppressed SREBP1 and FAS expression in the livers of LepR KO rats than CR alone, thereby improving host lipid metabolism. Conclusion: This study demonstrated that EGCG enhance the improvements of CR on hepatic steatosis and obesity in LepR KO rats, and reduce its adverse outcomes, especially in reducing hepatic lipogenesis and maintaining homeostasis of gut microbiota. This study provides a dietary strategy for preventing weight rebound following the transition from CR to a free diet by supplementing EGCG, suggesting that CR plus EGCG may offer a promising therapy for managing obesity in humans.
C1 [Wu, Guohuo; Du, Zhaofeng] Fuyang Normal Univ, Engn Technol Res Ctr Antiaging Chinese Herbal Med, Sch Biol & Food Engn, Fuyang, Peoples R China.
   [Gu, Wei] Anhui Med Univ, Lab Anim Ctr, Hefei, Peoples R China.
   [Wu, Guohuo; Du, Zhaofeng; Han, Tingting; Xie, Zhongwen; Gu, Wei] Anhui Agr Univ, Sch Tea & Food Sci Technol, State Key Lab Tea Plant Biol & Utilizat, Hefei, Peoples R China.
   [Wang, Mengdi] Fuyang Normal Univ, Affiliated Hosp 1, Dept Gen Surg, Fuyang, Peoples R China.
   [Li, Zhuang] Anhui Agr Univ, Biotechnol Ctr, Hefei, Peoples R China.
C3 Fuyang Normal University; Anhui Medical University; Anhui Agricultural
   University; Fuyang Normal University; Anhui Agricultural University
RP Gu, W (corresponding author), Anhui Med Univ, Lab Anim Ctr, Hefei, Peoples R China.; Xie, ZW; Gu, W (corresponding author), Anhui Agr Univ, Sch Tea & Food Sci Technol, State Key Lab Tea Plant Biol & Utilizat, Hefei, Peoples R China.
EM zhongwenxie@ahau.edu.cn; guwei_public@163.com
RI Xie, Zhongwen/I-7705-2019
FU Natural Science Research of Education Department of Anhui Province
   [2024AH051472]; Biological and Medical Sciences of Applied Summit
   Nurturing Disciplines in Anhui Province - Anhui Education Secretary
   Department [[2023] 13]; University Synergy Innovation Program of Anhui
   Province [GXXT-2019-49]
FX This research was funded by the key projects of Natural Science Research
   of Education Department of Anhui Province (2024AH051472) ; the
   Biological and Medical Sciences of Applied Summit Nurturing Disciplines
   in Anhui Province, grant number Anhui Education Secretary Department
   [2023] 13; the grant for University Synergy Innovation Program of Anhui
   Province (Grant No GXXT-2019-49) .
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NR 33
TC 0
Z9 0
U1 6
U2 6
PU ELSEVIER GMBH
PI MUNICH
PA HACKERBRUCKE 6, 80335 MUNICH, GERMANY
SN 0944-7113
EI 1618-095X
J9 PHYTOMEDICINE
JI Phytomedicine
PD JUN
PY 2025
VL 141
AR 156744
DI 10.1016/j.phymed.2025.156744
PG 12
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA 1QI7B
UT WOS:001471144700001
PM 40228342
DA 2025-06-11
ER

PT J
AU Simao, AL
   Afonso, MB
   Rodrigues, PM
   Gama-Carvalho, M
   Machado, MV
   Cortez-Pinto, H
   Rodrigues, CMP
   Castro, RE
AF Simao, Andre L.
   Afonso, Marta B.
   Rodrigues, Pedro M.
   Gama-Carvalho, Margarida
   Machado, Mariana V.
   Cortez-Pinto, Helena
   Rodrigues, Cecilia M. P.
   Castro, Rui E.
TI Skeletal muscle miR-34a/SIRT1:AMPK axis is activated in experimental and
   human non-alcoholic steatohepatitis
SO JOURNAL OF MOLECULAR MEDICINE-JMM
LA English
DT Article
DE NASH; miRNA-34a; SIRT1; AMPK; Mitochondrial dysfunction
ID FATTY LIVER-DISEASE; INSULIN-RESISTANCE; MITOCHONDRIAL DYSFUNCTION;
   URSODEOXYCHOLIC ACID; PROTEIN EXPRESSION; CHOLINE-DEFICIENT; AMPK;
   KINASE; SIRT1; METABOLISM
AB Non-alcoholic fatty liver disease (NAFLD) pathogenesis associates with intramyocellular lipid deposition and mitochondrial dysfunction. microRNAs (miRs), including pro-apoptotic miR-34a, are modulated during disease progression in liver tissue and plasma. We aimed to investigate the functional role of the miR-34a/SIRT1:AMP-activated protein kinase (AMPK) pathway in modulating local mitochondrial dysfunction in the skeletal muscle of human and experimental non-alcoholic steatohepatitis. Muscle biopsies were obtained from morbid obese NAFLD patients undergoing bariatric surgery. C57BL/6N mice were fed different NAFLD-inducing diets and C2C12 muscle cells incubated with palmitic acid (PA) in the presence or absence of an AMPK activator, or upon miR-34a functional modulation. Several muscle miRNAs, including miR-34a, were found increased with human NAFLD progression. Activation of the miR-34a/SIRT1:AMPK pathway, concomitant with impairment in insulin signalling mediators and deregulation of mitochondrial-shaping proteins, was evident in C2C12 cells incubated with PA, as well as in the skeletal muscle of all three diet-induced NAFLD mice models. Functional studies established the association between miR-34a- and PA-induced muscle cell deregulation. Of note, activation of AMPK almost completely prevented miR-34a- and PA-induced cellular stress. In addition, the miR-34a/SIRT1:AMPK pathway and mitochondrial dynamics dysfunction were also found amplified in muscle of human NAFLD. Finally, muscle miR-34a expression and mitofusin 2 (Mfn2) protein levels correlated with hallmarks of NAFLD and disease progression. Our results indicate that activation of the miR-34a/SIRT1:AMPK pathway leads to mitochondrial dynamics dysfunction in skeletal muscle of human and experimental NAFLD, representing an appealing prospective target in metabolic syndrome.Key messagesSkeletal muscle microRNAs are modulated during NAFLD progression.Palmitic acid-induced muscle cell dysfunction occurs, at least in part, through activation of the miR-34a/SIRT1:AMPK pathway.miR-34a/SIRT1:AMPK activation associates with mitochondria dynamics dysfunction in human NAFLD.
C1 [Simao, Andre L.; Afonso, Marta B.; Rodrigues, Pedro M.; Rodrigues, Cecilia M. P.; Castro, Rui E.] Univ Lisbon, Res Inst Med iMed ULisboa, Fac Pharm, Ave Prof Gama Pinto, P-1649003 Lisbon, Portugal.
   [Gama-Carvalho, Margarida] Univ Lisbon, BioISI Biosyst & Integrat Sci Inst, Fac Sci, Lisbon, Portugal.
   [Machado, Mariana V.; Cortez-Pinto, Helena] Hosp Santa Maria, Gastroenterol, Lisbon, Portugal.
C3 Universidade de Lisboa; Universidade de Lisboa; BIOISI; Universidade de
   Lisboa; Hospital Santa Maria
RP Castro, RE (corresponding author), Univ Lisbon, Res Inst Med iMed ULisboa, Fac Pharm, Ave Prof Gama Pinto, P-1649003 Lisbon, Portugal.
EM ruieduardocastro@ff.ulisboa.pt
RI Castro, Rui/AAG-4179-2021; Rodrigues, Pedro/GOP-0244-2022; Cortez-Pinto,
   Helena/AAN-2712-2020; Rodrigues, Pedro/M-6227-2017; da Gama Carvalho,
   Margarida/E-6180-2012; Afonso, Marta/N-5202-2017; Simao,
   Andre/M-9767-2018; Pereira Rodrigues, Cecilia Maria/M-3572-2013; Castro,
   Rui/I-2975-2013
OI Rodrigues, Pedro/0000-0001-6193-7436; da Gama Carvalho,
   Margarida/0000-0002-0365-6916; Afonso, Marta/0000-0003-3011-4941; Simao,
   Andre/0000-0002-5986-1089; Pereira Rodrigues, Cecilia
   Maria/0000-0002-4829-754X; Castro, Rui/0000-0002-7417-0091;
   Cortez-Pinto, Helena/0000-0002-8537-8744
FU Gilead Sciences Research Scholars Program in International Liver
   Disease; Fundacao para a Ciencia e a Tecnologia (FCT)
   [PTDC/BIM-MEC/0895/2014, UID/DTP/04138/2013, SFRH/BD/91119/2012,
   SFRH/BD/88212/2012, SFRH/BD/104160/2014]; FCT/MCTES/PIDDAC, Portugal
   [UID/MULTI/04046/2013]; Fundação para a Ciência e a Tecnologia
   [SFRH/BD/104160/2014, SFRH/BD/91119/2012, SFRH/BD/88212/2012,
   PTDC/BIM-MEC/0895/2014] Funding Source: FCT
FX We thank Tania Carvalho, Histology and Comparative Pathology Laboratory,
   Instituto de Medicina Molecular, for the histological and pathology
   analyses and Dr<SUP>a</SUP> Elisa Alves, Clinical Analysis Core
   Laboratory, Faculty of Pharmacy, University of Lisbon, for serum
   analyses. The study was supported in part by Gilead Sciences Research
   Scholars Program in International Liver Disease and Fundacao para a
   Ciencia e a Tecnologia (FCT) through grants PTDC/BIM-MEC/0895/2014 and
   UID/DTP/04138/2013, and fellowships SFRH/BD/91119/2012 (MBA),
   SFRH/BD/88212/2012 (PMR), and SFRH/BD/104160/2014 (ALS). Work in MGC lab
   is supported by a centre grant to BioISI, reference
   UID/MULTI/04046/2013, from FCT/MCTES/PIDDAC, Portugal.
CR Adrian L, 2017, LIPIDS, V52, P737, DOI 10.1007/s11745-017-4285-7
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NR 50
TC 28
Z9 30
U1 0
U2 23
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0946-2716
EI 1432-1440
J9 J MOL MED
JI J. Mol. Med.
PD AUG
PY 2019
VL 97
IS 8
BP 1113
EP 1126
DI 10.1007/s00109-019-01796-8
PG 14
WC Genetics & Heredity; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Genetics & Heredity; Research & Experimental Medicine
GA IJ4BO
UT WOS:000475849700005
PM 31139863
DA 2025-06-11
ER

PT J
AU Walters, BK
   Read, CR
   Estes, AR
AF Walters, Benjamin K.
   Read, Connor R.
   Estes, A. Reed
TI The effects of resistance training, overtraining, and early
   specialization on youth athlete injury and development
SO JOURNAL OF SPORTS MEDICINE AND PHYSICAL FITNESS
LA English
DT Review
DE Athletic injuries; Adolescent; Resistance training; Growth and
   development
ID POSITION STATEMENT; BASEBALL PITCHERS; OVERUSE INJURIES; MUSCULAR
   STRENGTH; PHYSICAL-ACTIVITY; CONCEPTUAL-MODEL; MOVEMENT SKILLS;
   DOSE-RESPONSE; SHOULDER PAIN; RISK-FACTORS
AB INTRODUCTION: In 2014, 60 million youth ages 6-18 participated in some form of generalized athletics. Around 3.5 million children are injured annually participating in organized sport or recreational activities. While sound physical education can decrease the burden of youth sports injuries, the median annual physical education budget of $ 764 for USA elementary, middle, and high schools may not allow enough flexibility to apply evidenced-based guidelines.
   EVIDENCE ACQUISITION: The topics were selected after a careful review of the 2016 National Strength and Conditioning Association Position Statement on Long-Term Athletic Development. Articles used to summarize the topics were located by using and cross-referencing sources from this statement. PubMed searches were also conducted using the key words "youth sports injuries," "early sports specialization," " training and maturation," "training versus developmental stage," and "long-term athletic development."
   EVIDENCE SYNTHESIS: Youth resistance training has been shown to decrease not only the risk of injury, but also of the development of diabetes and metabolic syndrome. Adequate recovery time also decreases injury risk, and resources such as the RESTQ-Sport are available to help coaches identify stress-recovery imbalances, which can be detected two months before an athlete becomes overreached. Through early detection of overtraining, a significant proportion of overuse injuries can be prevented. Early specialization causes fewer muscle groups to be worked and increased repetition, theoretically increasing the risk of injury and early sport dropout. Prior to puberty, increased neuronal activation and adaptation can be achieved through focusing on agility, balance and coordination, thus taking advantage of increased synaptoplasticity. In these early years, neuronal stimulation is more important than muscle hypertrophy, which plays a greater role in athletic development after puberty.
   CONCLUSIONS: A substantial proportion of youth injuries are preventable. Coaches and physical educators who correctly understand and apply the principles outlined in this review can help youth under their supervision engage in healthy training for sport.
C1 [Walters, Benjamin K.; Read, Connor R.] Univ Alabama Birmingham, Sch Med, Birmingham, AL USA.
   [Estes, A. Reed] Univ Alabama Birmingham, Dept Sports Med, Birmingham, AL USA.
C3 University of Alabama System; University of Alabama Birmingham;
   University of Alabama System; University of Alabama Birmingham
RP Estes, AR (corresponding author), 1600 7th Ave S,Lowder Bldg Suite 402, Birmingham, AL 35233 USA.
EM reed.estes@gmail.com
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NR 60
TC 29
Z9 32
U1 5
U2 124
PU EDIZIONI MINERVA MEDICA
PI TURIN
PA CORSO BRAMANTE 83-85 INT JOURNALS DEPT., 10126 TURIN, ITALY
SN 0022-4707
EI 1827-1928
J9 J SPORT MED PHYS FIT
JI J. Sports Med. Phys. Fit.
PD SEP
PY 2018
VL 58
IS 9
BP 1339
EP 1348
DI 10.23736/S0022-4707.17.07409-6
PG 10
WC Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Sport Sciences
GA GU3XE
UT WOS:000445212900023
PM 28597618
DA 2025-06-11
ER

PT J
AU Mitrovic, M
   Ilic, T
   Stokic, E
   Paro, JN
   Naglic, DT
   Bajkin, I
   Icin, T
AF Mitrovic, Milena
   Ilic, Tatjana
   Stokic, Edita
   Paro, Jovanka Novakovic
   Naglic, Dragana Tomic
   Bajkin, Ivana
   Icin, Tijana
TI Influence of glucoregulation quality on C-reactive protein,
   interleukin-6 and tumor necrosis factor-α level in patients with
   diabetes type 1
SO VOJNOSANITETSKI PREGLED
LA English
DT Article
DE diabetes mellitus, type 1; blood glucose; c-reactive protein;
   interleukin-6; tumor necrosis factor-alpha; sensitivity and specificity
ID MICROVASCULAR COMPLICATIONS; METABOLIC SYNDROME; GLYCEMIC CONTROL;
   MELLITUS TYPE-1; ASSOCIATION; RISK; INFLAMMATION; MORTALITY; INSULIN;
   DISEASE
AB Background/Aim. Results of studies which have proved an increased inflammatory activity in diabetes type 1, have been published over recent years. One of possible mechanisms that are used to explain chronic inflammation in diabetes is the state of hyperglycemia leading to the enhanced synthesis of glycosylation end products (AGEs) which activate macrophages, increase the oxidative stress and affect the synthesis of interleukins (IL-1, IL-6), tumor necrosis factor-alpha (TNF-alpha) and C-reactive protein (CRP). The aim of the study was to determine the inflammatory markers (CRP, IL-6, TNF-alpha) in patients with diabetes type 1 and to establish their correlation with glucoregulation parameters and other cardiovascular risk factors as well as to compare them with the healthy controls. Methods. The study included 76 patients with diabetes type 1 and 30 healthy controls. We determined values of inflammatory markers (CRP, IL-6, TNF-alpha) and glucoregulation parameters (fasting glucose HbA(1c)). Results. The values of CRP (p = 0.014), IL-6 (p = 0.020) and TNF-alpha (p = 0.037) were statistically significantly higher in the diabetic patients than in the healthy controls. There was a positive correlation between CRP with postprandial glycemia (p = 0.004); the multivariate regression analysis revealed a statistically significant correlation between CRP and age (p = 0.001), smoking (p = 0.055), fasting glucose (p = 0.021) and triglycerides (p = 0.048) as well as between IL-6 and LDL-cholesterol (p = 0,009). No statistically significant correlations were found between glycosilated hemoglobin (HbA(1c)) and the inflammatory markers (CRP, IL-6 and TNF-alpha). Conclusion. The patients with type 1 diabetes were found to have a low level of inflammatory activity manifested by the increased values of CRP, IL-6 and TNF-alpha.
C1 [Mitrovic, Milena; Stokic, Edita; Paro, Jovanka Novakovic; Naglic, Dragana Tomic; Bajkin, Ivana; Icin, Tijana] Clin Ctr Vojvodina, Dept Endocrinol Diabet & Metab Dis, Novi Sad 21000, Serbia.
   [Ilic, Tatjana] Clin Ctr Vojvodina, Dept Nephrol & Clin Immunol, Novi Sad 21000, Serbia.
RP Mitrovic, M (corresponding author), Clin Ctr Vojvodina, Dept Endocrinol Diabet & Metab Dis, Hajduk Veljkova 1-3, Novi Sad 21000, Serbia.
EM luka.mitrovic@neobee.net
RI Icin, Tijana/GQZ-0076-2022
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NR 39
TC 4
Z9 8
U1 0
U2 3
PU MILITARY MEDICAL ACAD-INI
PI BELGRADE
PA CRNOTRAVSKA 17, PO BOX 33-35, BELGRADE, 11040, SERBIA
SN 0042-8450
EI 2406-0720
J9 VOJNOSANIT PREGL
JI Vojnosanit. Pregl.
PD SEP
PY 2011
VL 68
IS 9
BP 756
EP 761
DI 10.2298/VSP1109756M
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 836QU
UT WOS:000296127000006
PM 22046880
OA Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Pavlatou, MG
   Mastorakos, G
   Margeli, A
   Kouskouni, E
   Tentolouris, N
   Katsilambros, N
   Chrousos, GP
   Papassotiriou, I
AF Pavlatou, Maria G.
   Mastorakos, George
   Margeli, Alexandra
   Kouskouni, Evangelia
   Tentolouris, Nicholas
   Katsilambros, Nikos
   Chrousos, George P.
   Papassotiriou, Ioannis
TI Angiotensin blockade in diabetic patients decreases insulin
   resistance-associated low-grade inflammation
SO EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
LA English
DT Article
DE Angiotensin II; angiotensin receptor blockers; diabetes mellitus type 2;
   insulin resistance; interleukin-6
ID C-REACTIVE PROTEIN; CONVERTING ENZYME; RECEPTOR ANTAGONIST;
   ADIPOSE-TISSUE; AT1 RECEPTOR; SUBCLINICAL INFLAMMATION; BRAIN
   MICROVESSELS; OXIDATIVE STRESS; TYPE-2; INTERLEUKIN-6
AB P>Background
   Insulin-resistant states, such as metabolic syndrome and diabetes mellitus type 2 (DM2), have been associated with chronic low-grade systemic inflammation. Elevated levels of interleukin-6 (IL-6), monocyte chemoattractant protein (MCP-1) and C-reactive protein (hs-CRP), are found in patients with type 2 diabetes with and without complications. Angiotensin II (Ang II), a potent vasopressor, seems to regulate also the expression of the above inflammatory mediators acting as proinflammatory cytokine. In this study, we examined the effects of candesartan, an angiotensin receptror blocker, in the chronic low-grade inflammation observed in DM 2.
   Materials and methods
   Seventeen patients with DM2 of < 5 years duration were recruited for the study. Patients received 4 mg of candesartan, an angiotensin receptor blocker, for 6 months. Blood levels of IL-6, MCP-1, hs-CRP and other inflammatory indices were measured before and at the end of candesartan administration.
   Results
   At the end of treatment with candesartan, IL-6 levels decreased significantly (P < 0 center dot 05). Serum levels of MCP-1 and hs-CRP showed a trend for significant decrease with treatment (P < 0 center dot 08 and P < 0 center dot 09, respectively). Statistically significant correlations were found between hs-CRP and MCP-1 (r = 0 center dot 623, P < 0 center dot 05), IL-6 and MCP-1 (r = 0 center dot 703, P < 0 center dot 05) and TRT and MCP-1 (r = 0 center dot 752, P < 0 center dot 05), before but not at the end of candesartan administration.
   Conclusions
   Candesartan could decrease the low-grade inflammation of type 2 DM as shown by the decrease of inflammatory mediators. Thus, angiotensin receptor blockers could be useful for treating patients with DM2 not only for their antihypertensive capacity but also for their anti-inflammatory actions.
C1 [Margeli, Alexandra; Papassotiriou, Ioannis] Aghia Sophia Childrens Hosp, Dept Clin Biochem, Athens 11527, Greece.
   [Pavlatou, Maria G.; Chrousos, George P.] Univ Athens, Sch Med, Dept Pediat 1, GR-11527 Athens, Greece.
   [Mastorakos, George; Kouskouni, Evangelia] Univ Athens, Sch Med, Endocrine Unit, Dept Obstet & Gynecol 2, GR-11527 Athens, Greece.
   [Tentolouris, Nicholas; Katsilambros, Nikos] Univ Athens, Sch Med, Dept Propaedeut Med 1, GR-11527 Athens, Greece.
C3 The Aghia Sophia Children's Hospital; Athens Medical School; National &
   Kapodistrian University of Athens; Athens Medical School; National &
   Kapodistrian University of Athens; National & Kapodistrian University of
   Athens; Athens Medical School
RP Papassotiriou, I (corresponding author), Aghia Sophia Childrens Hosp, Dept Clin Biochem, Athens 11527, Greece.
EM biochem@paidon-agiasofia.gr
RI TENTOLOURIS, NIKOLAOS/AAH-6231-2019; Chrousos, George/G-8702-2011
FU Athens University
FX Funding was received from Athens University to Prof George Chrousos. The
   funding source played no role in the study design; in the collection,
   analysis, and interpretation of data; in the writing of the report; or
   in the decision to submit the report for publication.
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NR 47
TC 11
Z9 13
U1 1
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0014-2972
EI 1365-2362
J9 EUR J CLIN INVEST
JI Eur. J. Clin. Invest.
PD JUN
PY 2011
VL 41
IS 6
BP 652
EP 658
DI 10.1111/j.1365-2362.2010.02453.x
PG 7
WC Medicine, General & Internal; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Research & Experimental Medicine
GA 759FP
UT WOS:000290226400010
PM 21175613
DA 2025-06-11
ER

PT J
AU Chawla, I
   Dhanawat, M
   Sharma, M
   Gupta, S
AF Chawla, Isha
   Dhanawat, Meenakshi
   Sharma, Manu
   Gupta, Sumeet
TI Exploring the Potential Benefits of Bovine Colostrum Supplementation in
   the Management of Diabetes and Its Complications: A Comprehensive Review
SO CURRENT DIABETES REVIEWS
LA English
DT Review
DE Colostrum; supplementation therapy; management; diabetes; complications
ID IMMUNE COMPONENTS; OXIDATIVE STRESS; PASSIVE-IMMUNITY; GLYCEMIC CONTROL;
   BLOOD-GLUCOSE; CAMEL MILK; ANTIOXIDANTS; COWS; CYTOKINES;
   IMMUNOGLOBULINS
AB Diabetes is a metabolic illness marked by elevated levels of glucose in the bloodstream due to the inadequate production or use of insulin in the body. Diabetes can result in a range of consequences, with the most prevalent being cardiovascular disease, renal failure, vision loss, and limb removal. Natural compounds isolated from different sources, like colostrum, are the most important compounds for the treatment of diabetes. Colostrum is a form of lactation produced by mammals in the first days after giving birth to their offspring, having a rich source of constituents and showing multipharmacological properties.This review was prepared on the basis of a variety of authoritative search databases, including Google Scholar, Scopus, and PubMed. In addition, the publications and other online sources were also included. In the literature search, the terms "colostrum," "diabetes," "uses," "management," "constituent," "composition," "alternative sources," "mechanism of action," "preclinical," "clinical," "marketed formulations," and "patents" were utilized as keywords and collected from last two decades.Colostrum has been utilized as a treatment for a wide variety of illnesses due to its active constituents. A variety of colostrums are available in the market, like goat colostrum, porcine colostrum, sheep colostrum, human colostrum and many more. They have the full potential of nutrients like minerals, vitamins, lactose, essential enzymes, proteins and high concentrations of immunoproteins. Mostly, the colostrums are used for treating diabetes and its complications. Preclinical and clinical studies of metabolic syndrome, especially on diabetes and its complications, were also reported at the National and International levels, which evidently prove that the use of colostrums in the long term can be beneficial for various ailments associated with diabetes.In general, the findings of this review indicate that supplementation with colostrum may hold promise as a novel therapeutic intervention for people who have diabetes and its complications; however, additional research is required to fully understand its mechanisms of action and determine the best possible dosage as well as the time period of supplementation.
C1 [Chawla, Isha; Gupta, Sumeet] MM, MM Coll Pharm, Dept Pharmacol, Ambala 133207, India.
   [Dhanawat, Meenakshi] Amity Univ, Dept Pharmaceut Chem, Gurugram, Haryana, India.
   [Sharma, Manu] Natl Forens Sci Lab, Dept Pharmaceut Sci, New Delhi, India.
C3 Maharishi Markandeshwar University
RP Gupta, S (corresponding author), MM, MM Coll Pharm, Dept Pharmacol, Ambala 133207, India.
EM sumeetgupta25@gmail.com
RI Bansal, Seema/GLN-7402-2022; Sharma, Manu/GYV-6165-2022; chawla,
   isha/GQP-9727-2022; Dhanawat, Meenakshi/AFT-0985-2022
OI CHAWLA, ISHA/0000-0002-8619-4410
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NR 104
TC 0
Z9 0
U1 4
U2 6
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1573-3998
EI 1875-6417
J9 CURR DIABETES REV
JI Curr. Diabetes Reviews
PY 2025
VL 21
IS 2
DI 10.2174/0115733998275676240202065952
EA FEB 2024
PG 15
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA K7I3Q
UT WOS:001178460500001
PM 38415443
DA 2025-06-11
ER

PT J
AU Graham, DS
   Liu, G
   Arasteh, A
   Yin, XM
   Yan, SM
AF Graham, Dalton S.
   Liu, Gang
   Arasteh, Ailar
   Yin, Xiao-Ming
   Yan, Shengmin
TI Ability of high fat diet to induce liver pathology correlates with the
   level of linoleic acid and Vitamin E in the diet
SO PLOS ONE
LA English
DT Article
ID LIPID-PEROXIDATION; OXIDATIVE STRESS; DISEASE; METABOLITES; OBESITY;
   ANANDAMIDE; FIBROSIS; ETHANOL; 2-AG; MICE
AB Increased uptake of fat, such as through the ingestion of high fat diet (HFD), can lead to fatty liver diseases and metabolic syndrome. It is not clear whether certain fatty acids may be more pathogenic than others to the liver. Linoleic acid (LA) is the most abundant polyunsaturated fatty acid in the Western diet and its excessive consumption can lead to increased lipid peroxidation. We hypothesized that a high level of LA in HFD will contribute significantly to the hepatic steatosis and injury, whereas vitamin E (VIT-E) may reverse the effects from LA by inhibiting lipid peroxidation. To test this hypothesis, we fed mice with the following diets for 20 weeks: a standard low-fat diet (CHOW), HFD with a low level of LA (LOW-LA, 1% of energy from LA), HFD with a high level of LA (HI-LA, 8% of energy from LA), or HI-LA diet with VIT-E supplement (HI-LA + VIT-E). We found that the HI-LA diet resulted in more body weight gain, larger adipocyte area, and higher serum levels of triglycerides (TG) and free fatty acids (FFA) relative to the CHOW and LOW-LA diets. In mice fed with the HI-LA diet, severer hepatic steatosis was seen with higher levels of hepatic TG and FFA. Expression of genes related to lipid metabolism was altered in the liver by HI-LA diet, including fibroblast growth factor 21 (Fgf21), cluster of differentiation 36 (Cd36), stearoyl-CoA desaturase 1 (Scd1), and acyl-CoA oxidase 1 (Acox1). Liver injury, inflammation and fibrotic response were all enhanced in mice fed with the HI-LA diet when compared with the LOW-LA diet. Notably, addition of VIT-E supplement, which restores the proper VIT-E/PUFA ratio, significantly reduced the detrimental effects of the high level of LA. Taken together, our results suggest that a high level of LA and a low ratio of VIT-E/PUFA in HFD can contribute significantly to metabolic abnormalities and hepatic injury.
C1 [Graham, Dalton S.; Liu, Gang; Arasteh, Ailar; Yin, Xiao-Ming; Yan, Shengmin] Tulane Univ, Sch Med, Dept Pathol & Lab Med, New Orleans, LA 70112 USA.
C3 Tulane University
RP Yin, XM; Yan, SM (corresponding author), Tulane Univ, Sch Med, Dept Pathol & Lab Med, New Orleans, LA 70112 USA.
EM syan2@tulane.edu; xmyin@tulane.edu
RI Yan, Xiaohui/T-8783-2019; Yan, Shengmin/W-4643-2017
OI Yan, Shengmin/0000-0003-4012-9557; Arasteh, Ailar/0000-0003-0893-9904
FU National Institute of Diabetes and Digestive and Kidney Diseases [R01
   DK116605]; Louisiana Clinical and Translational Science Center Pilot
   Grant [U54 GM104940]
FX National Institute of Diabetes and Digestive and Kidney Diseases (R01
   DK116605)(XMY) and the Louisiana Clinical and Translational Science
   Center Pilot Grant (U54 GM104940)(SY). The funders and sponsors did not
   play a role in the study design, data collection and analysis, decision
   to publish, or preparation of the manuscript.
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NR 48
TC 8
Z9 8
U1 0
U2 3
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JUN 2
PY 2023
VL 18
IS 6
AR e0286726
DI 10.1371/journal.pone.0286726
PG 15
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA I1YL4
UT WOS:001000808800027
PM 37267350
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Ketkar, H
   Alqahtani, M
   Tang, S
   Parambath, SP
   Bakshi, CS
   Jain, S
AF Ketkar, Harshada
   Alqahtani, Maha
   Tang, Samantha
   Parambath, Sreema Puthiya
   Bakshi, Chandra Shekhar
   Jain, Sudhir
TI Chronically hypertensive transgenic mice expressing human AT1R
   haplotype-I exhibit increased susceptibility to Francisella
   tularensis
SO FRONTIERS IN MICROBIOLOGY
LA English
DT Article
DE Francisella; aging; transgenic; hypertension; inflammation; sepsis;
   cytokine storm; respiratory tularemia
ID INNATE IMMUNE-RESPONSES; CHEMOKINE RECEPTORS; OXIDATIVE STRESS; AGED
   MICE; CELL; INFLAMMATION; INFECTION; MECHANISMS; RESISTANCE; DISEASE
AB Age-related illnesses, including hypertension and accompanying metabolic disorders, compromise immunity and exacerbate infection-associated fatalities. Renin-angiotensin system (RAS) is the key mechanism that controls blood pressure. Upregulation of RAS through angiotensin receptor type 1 (AT1R), a G-protein coupled receptor, contributes to the pathophysiological consequences leading to vascular remodeling, hypertension, and end-organ damage. Genetic variations that increase the expression of human AT1R may cause the above pathological outcomes associated with hypertension. Previously we have shown that our chronically hypertensive transgenic (TG) mice containing the haplotype-I variant (Hap-I, hypertensive genotype) of human AT1R (hAT1R) gene are more prone to develop the metabolic syndrome-related disorders as compared to the TG mice containing the haplotype-II variant (Hap-II, normotensive genotype). Since aging and an increased risk of hypertension can impact multiple organ systems in a complex manner, including susceptibility to various infections, the current study investigated the susceptibility and potential effect of acute bacterial infection using a Gram-negative intracellular bacterial pathogen, Francisella tularensis in our hAT1R TG mice. Our results show that compared to Hap-II, F. tularensis-infected aged Hap-I TG mice have significantly higher mortality post-infection, higher bacterial load and lung pathology, elevated inflammatory cytokines and altered gene expression profile favoring hypertension and inflammation. Consistent with worsened phenotype in aged Hap-I mice post-Francisella infection, gene expression profiles from their lungs revealed significantly altered expression of more than 1,400 genes. Furthermore, bioinformatics analysis identified genes associated with RAS and IFN-gamma pathways regulating blood pressure and inflammation. These studies demonstrate that haplotype-dependent over-expression of the hAT1R gene leads to enhanced susceptibility and lethality due to F. tularensis LVS infection, which gets aggravated in aged animals. Clinically, these findings will help in exploring the role of AT1R-induced hypertension and enhanced susceptibility to infection-related respiratory diseases.
C1 [Ketkar, Harshada; Alqahtani, Maha; Tang, Samantha; Parambath, Sreema Puthiya; Bakshi, Chandra Shekhar; Jain, Sudhir] New York Med Coll, Dept Pathol Microbiol & Immunol, Valhalla, NY 10595 USA.
C3 New York Medical College
RP Bakshi, CS; Jain, S (corresponding author), New York Med Coll, Dept Pathol Microbiol & Immunol, Valhalla, NY 10595 USA.
EM Shekhar_Bakshi@nymc.edu; sjain5@nymc.edu
FU National Institutes of Health [R01HL146628]
FX Funding This research was funded by National Institutes of Health grant
   R01HL146628 to SJ.
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NR 72
TC 2
Z9 2
U1 0
U2 1
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1664-302X
J9 FRONT MICROBIOL
JI Front. Microbiol.
PD MAY 17
PY 2023
VL 14
AR 1173577
DI 10.3389/fmicb.2023.1173577
PG 15
WC Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Microbiology
GA H7HK0
UT WOS:000997628100001
PM 37266014
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Yang, HJ
   Kong, B
   Shuai, W
   Zhang, JJ
   Huang, H
AF Yang, Hong-Jie
   Kong, Bin
   Shuai, Wei
   Zhang, Jing-jing
   Huang, He
TI Shensong Yangxin attenuates metabolic syndrome-induced atrial
   fibrillation via inhibition of ferroportin-mediated intracellular iron
   overload
SO PHYTOMEDICINE
LA English
DT Article
DE Shensong Yangxin; Atrial fibrillation; Ferroportin; Oxidative stress;
   Intracellular iron overload
ID ASSOCIATION; RISK; SUSCEPTIBILITY; ACCUMULATION; PROGRESSION;
   CONDUCTION; FIBROSIS; RATS
AB Background: Shensong Yangxin (SSYX) is a traditional Chinese medicine been widely used clinically to treat various arrhythmias including atrial fibrillation (AF). However, the role and precise mechanism of SSYX in MS induced AF have not yet been elucidated. Purpose: To elucidate the protective effects of SSYX on MS-induced AF and its possible mechanisms of action.Methods: Male Wistar rats (180-220 g) were fed a 16-week high-carbohydrate, high-fat (HCHF) diet together with 25% fructose in drinking water to produce a MS model. Low-concentration (SSYX-L, 0.4 g/kg) and high concentration (SSYX-H, 0.8 g/kg) of SSYX were given by daily gavage 8-weeks following HCHF diet for 8 weeks. In vivo electrophysiological study, histological analysis, RNA-sequence (RNA-Seq) and gene ontology (GO) analysis, qRT-PCR and western blot were performed.Results: Both low-concentration and high-concentration of SSYX could inhibit MS-induced AF susceptibility, electrical remodeling and structural remodeling. Results from RNA-sequence analysis revealed intracellular iron homeostasis mediated the protective effect of SSYX against MS. In vivo and in vitro experiments both demonstrated that SSYX up-regulated ferroportin (Fpn) expression and ameliorated intracellular iron overload induced by MS. To verified whether Fpn is the target of SSYX and intracellular iron overload mediated the protective effect of SSYX against MS, adeno-associated virus type 9 (AAV9) delivery system was used. Knocking down Fpn (AAV9-shFpn) markedly aggravated the reactive oxygen species (ROS) production, electrical remodeling and atrial fibrosis induced by MS, leading to a further increase of AF susceptibility induced by MS.Conclusion: Our study demonstrated for the first time that SSYX reduced AF susceptibility, inhibited electrical remodeling and structural remodeling via up-regulating Fpn, decreasing intracellular iron overload and reducing ROS production. These results suggest that SSYX might be a potential therapeutic agent for the treatment of MS induced AF.
C1 [Yang, Hong-Jie; Kong, Bin; Shuai, Wei; Zhang, Jing-jing; Huang, He] Wuhan Univ, Dept Cardiol, Renmin Hosp, 238 Jiefang Rd, Wuhan 430060, Peoples R China.
   [Yang, Hong-Jie; Kong, Bin; Shuai, Wei; Zhang, Jing-jing; Huang, He] Wuhan Univ, Cardiovasc Res Inst, 238 Jiefang Rd, Wuhan 430060, Peoples R China.
   [Yang, Hong-Jie; Kong, Bin; Shuai, Wei; Zhang, Jing-jing; Huang, He] Hubei Key Lab Cardiol, 238 Jiefang Rd, Wuhan 430060, Peoples R China.
C3 Wuhan University; Wuhan University
RP Huang, H (corresponding author), Wuhan Univ, Dept Cardiol, Renmin Hosp, 238 Jiefang Rd, Wuhan 430060, Peoples R China.
EM huanghe1977@whu.edu.cn
RI huang, he/HAZ-0257-2022; Yang, Hongjie/AAJ-9814-2021
OI Huang, He/0000-0003-3915-2733
FU Key R&D Program of China [2017YFC1700504]; National Natural
   ScienceFoundation of China [82070330]
FX Acknowledgments This work was supported by grants from the Key R&D
   Program of China (No. 2017YFC1700504) , and the National Natural
   ScienceFoundation of China (No. 82070330) .
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NR 48
TC 20
Z9 21
U1 3
U2 26
PU ELSEVIER GMBH
PI MUNICH
PA HACKERBRUCKE 6, 80335 MUNICH, GERMANY
SN 0944-7113
EI 1618-095X
J9 PHYTOMEDICINE
JI Phytomedicine
PD JUL
PY 2022
VL 101
AR 154086
DI 10.1016/j.phymed.2022.154086
EA APR 2022
PG 13
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA 1F4LP
UT WOS:000795140500003
PM 35421806
DA 2025-06-11
ER

PT J
AU Freire-Regatillo, A
   Fernandez-Gomez, MJ
   Diaz, F
   Barrios, V
   Sanchez-Jabonero, I
   Frago, LM
   Argente, J
   Garcia-Segura, LM
   Chowen, JA
AF Freire-Regatillo, Alejandra
   Fernandez-Gomez, Maria J.
   Diaz, Francisca
   Barrios, Vicente
   Sanchez-Jabonero, Ismael
   Frago, Laura M.
   Argente, Jesus
   Miguel Garcia-Segura, Luis
   Chowen, Julie A.
TI Sex differences in the peripubertal response to a short-term, high-fat
   diet intake
SO JOURNAL OF NEUROENDOCRINOLOGY
LA English
DT Article
DE age; glia; high-fat diet; obesity; sex differences
ID BETA/NF-KAPPA-B; BODY-WEIGHT; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   PALATABLE DIET; ER STRESS; PUBERTY; ADIPOSE; LEPTIN; ACTIVATION
AB Obesity is one of the most important health problems facing developed countries because being overweight is associated with a higher incidence of type 2 diabetes, cardiovascular disease and cancer, as well as other comorbidities. Although increased weight gain results from a combination of poor dietary habits and decreased energy expenditure, not all individuals have equal propensities to gain weight or to develop secondary complications of obesity. This is partially a result not only of genetics, including sex, but also the time during which an individual is exposed to an obesogenic environment. In the present study, we have compared the response of male and female mice to short-term exposure to a high-fat diet (HFD) or a low-fat diet during the peripubertal period (starting at 42 days of age) because this is a stage of dramatic hormonal and metabolic modifications. After 1 week on a HFD, there was no significant increase in body weight, although females significantly increased their energy intake. Serum leptin levels increased in both sexes, even though no change in fat mass was detected. Glyceamia and homeostasis model assessment increased in males, suggesting a rapid change in glucose metabolism. Hypothalamic pro-opiomelanocortin mRNA levels were significantly higher in females on a HFD compared to all other groups, which may be an attempt to reduce their increased energy intake. Hypothalamic inflammation and gliosis have been implicated in the development of secondary complications of obesity; however, no indication of activation of inflammatory processes or gliosis was found in response to 1 week of HFD in the hypothalamus, hippocampus or cerebellum of these young mice. These results indicate that there are both sex and age effects in the response to poor dietary intake because peripubertal male and female mice respond differently to short-term dietary changes and this response is different from that reported in adult rodents.
C1 [Freire-Regatillo, Alejandra; Fernandez-Gomez, Maria J.; Diaz, Francisca; Barrios, Vicente; Frago, Laura M.; Argente, Jesus; Chowen, Julie A.] Hosp Infantil Univ Nino Jesus, Inst Invest Princesa, Dept Endocrinol, Madrid, Spain.
   [Freire-Regatillo, Alejandra; Frago, Laura M.; Argente, Jesus] Univ Autonoma Madrid, Fac Med, Dept Pediat, Madrid, Spain.
   [Freire-Regatillo, Alejandra; Diaz, Francisca; Barrios, Vicente; Frago, Laura M.; Argente, Jesus; Chowen, Julie A.] Inst Carlos III, CIBEROBN Ctr Invest Biomed Red Fisiopatol Obesida, Madrid, Spain.
   [Sanchez-Jabonero, Ismael] Hosp Infantil Univ Nino Jesus, Dept Anat Pathol, Madrid, Spain.
   [Argente, Jesus; Chowen, Julie A.] CEI UAM CSIC, IMDEA Food Inst, Madrid, Spain.
   [Miguel Garcia-Segura, Luis] CSIC, Inst Cajal, Madrid, Spain.
   [Miguel Garcia-Segura, Luis] Inst Carlos III, CIBERFES, Madrid, Spain.
C3 Autonomous University of Madrid; CIBER - Centro de Investigacion
   Biomedica en Red; CIBEROBN; IMDEA Food Institute; Consejo Superior de
   Investigaciones Cientificas (CSIC); Consejo Superior de Investigaciones
   Cientificas (CSIC); CSIC - Instituto Cajal (IC); CIBER - Centro de
   Investigacion Biomedica en Red; CIBERFES
RP Chowen, JA (corresponding author), Hosp Infantil Univ Nino Jesus, Dept Endocrinol, Ave Menendez Pelayo 65, Madrid 28009, Spain.
EM julieann.chowen@salud.madrid.org
RI Barrios Sabador, Vicente/N-6982-2016; Garcia-Segura, Luis/U-3711-2017;
   Argente, Jesús/M-5226-2019; Frago, Laura M/B-9661-2012; Freire
   Fernandez-Regatillo, Alejandra/K-1158-2014; Chowen, Julie/C-8979-2011
OI Frago, Laura M/0000-0002-5927-9240; Freire Fernandez-Regatillo,
   Alejandra/0000-0002-8202-5871; Chowen, Julie/0000-0002-4770-2291
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NR 69
TC 17
Z9 18
U1 1
U2 10
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0953-8194
EI 1365-2826
J9 J NEUROENDOCRINOL
JI J. Neuroendocrinol.
PD JAN
PY 2020
VL 32
IS 1
AR e12756
DI 10.1111/jne.12756
PG 11
WC Endocrinology & Metabolism; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology
GA KG4ND
UT WOS:000509921400009
PM 31179596
DA 2025-06-11
ER

PT J
AU Lee, H
   Ahn, J
   Shin, SS
   Yoon, M
AF Lee, Hyunghee
   Ahn, Jiwon
   Shin, Soon Shik
   Yoon, Michung
TI Ascorbic acid inhibits visceral obesity and nonalcoholic fatty liver
   disease by activating peroxisome proliferator-activated receptor α in
   high-fat-diet-fed C57BL/6J mice
SO INTERNATIONAL JOURNAL OF OBESITY
LA English
DT Article
ID COMPOSITION GAMBIGYEONGSINHWAN 4; BODY-MASS INDEX; VITAMIN-C; OXIDATIVE
   STRESS; LIPID-ACCUMULATION; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   PPAR-ALPHA; STEATOHEPATITIS; APOPTOSIS
AB Background/objectives: Ascorbic acid is a known cofactor in the biosynthesis of carnitine, a molecule that has an obligatory role in fatty acid oxidation. Our previous studies have demonstrated that obesity is regulated effectively through peroxisome proliferator-activated receptor alpha (PPAR alpha)-mediated fatty acid beta-oxidation. Thus, this study aimed to determine whether ascorbic acid can inhibit obesity and nonalcoholic fatty liver disease (NAFLD) in part through the actions of PPAR alpha.
   Design: After C57BL/6J mice received a low-fat diet (LFD, 10% kcal fat), a high-fat diet (HFD, 45% kcal fat), or the same HFD supplemented with ascorbic acid (1% w/w) (HFD-AA) for 15 weeks, variables and determinants of visceral obesity and NAFLD were examined using metabolic measurements, histology, and gene expression.
   Results: Compared to HFD-fed obese mice, administration of HFD-AA to obese mice reduced body weight gain, visceral adipose tissue mass, and visceral adipocyte size without affecting food consumption profiles. Concomitantly, circulating ascorbic acid concentrations were significantly higher in HFD-AA mice than in RFD mice. Ascorbic acid supplementation increased the mRNA levels of PPAR alpha and its target enzymes involved in fatty acid beta-oxidation in visceral adipose tissues. Consistent with the effects of ascorbic acid on visceral obesity, ascorbic acid not only inhibited hepatic steatosis but also increased the mRNA levels of PPAR alpha-dependent fatty acid beta-oxidation genes in livers. Similarly, hepatic inflammation, fibrosis, and apoptosis were also decreased during ascorbic acid-induced inhibition of visceral obesity. In addition, serum levels of alanine aminotransferase, aspartate aminotransferase, total cholesterol, and LDL cholesterol were lower in HFDAA-fed mice than in those of HFD-fed mice.
   Conclusions: These results suggest that ascorbic acid seems to suppress HFD-induced visceral obesity and NAFLD in part through the activation of PPAR alpha.
C1 [Lee, Hyunghee; Yoon, Michung] Mokwon Univ, Dept Biomed Engn, Daejeon 35349, South Korea.
   [Ahn, Jiwon] Korea Res Inst Biosci & Biotechnol, Genome Res Ctr, Daejeon 34141, South Korea.
   [Shin, Soon Shik] Dong Eui Univ, Coll Korean Med, Dept Formula Sci, Busan 47340, South Korea.
C3 Mokwon University; Korea Research Institute of Bioscience &
   Biotechnology (KRIBB); Dong-Eui University
RP Yoon, M (corresponding author), Mokwon Univ, Dept Biomed Engn, Daejeon 35349, South Korea.; Shin, SS (corresponding author), Dong Eui Univ, Coll Korean Med, Dept Formula Sci, Busan 47340, South Korea.
EM ssshin@deu.ac.kr; yoon60@mokwon.ac.kr
RI Lee, Jong-Sub/G-2752-2012
FU National Research Foundation of Korea (NRF) - Korea Government (MEST)
   [2015R1A1A3A04001016, 2018R1D1A1B07042585]; Korea Health Industry
   Development Institute (KHIDI) Grant - Korea Government (MHW) [HI16C0753]
FX This work supported by the National Research Foundation of Korea (NRF)
   Grant funded by the Korea Government (MEST) (2015R1A1A3A04001016 and
   2018R1D1A1B07042585) and the Korea Health Industry Development Institute
   (KHIDI) Grant funded by the Korea Government (MHW) (HI16C0753).
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NR 60
TC 51
Z9 54
U1 2
U2 18
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0307-0565
EI 1476-5497
J9 INT J OBESITY
JI Int. J. Obes.
PD AUG
PY 2019
VL 43
IS 8
BP 1620
EP 1630
DI 10.1038/s41366-018-0212-0
PG 11
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA IN8AH
UT WOS:000478902500015
PM 30283077
DA 2025-06-11
ER

PT J
AU Amos-Kroohs, RM
   Nelson, DW
   Hacker, TA
   Yen, CLE
   Smith, SM
AF Amos-Kroohs, Robyn M.
   Nelson, David W.
   Hacker, Timothy A.
   Yen, Chi-Liang Eric
   Smith, Susan M.
TI Does prenatal alcohol exposure cause a metabolic syndrome?
   (Non-)evidence from a mouse model of fetal alcohol spectrum disorder
SO PLOS ONE
LA English
DT Article
ID ETHANOL EXPOSURE; DEVELOPMENTAL ORIGINS; GLUCOSE-INTOLERANCE;
   INSULIN-RESISTANCE; GROWTH RESTRICTION; BIRTH-WEIGHT; OBESITY; CHILDREN;
   AGE; EXPRESSION
AB Although prenatal alcohol exposure (PAE) reduces offspring growth, it may increase obesity risk at adolescence. Animal models of PAE display glucose intolerance and increased adiposity, suggesting that PAE causes metabolic reprogramming. We tested this hypothesis in a mouse model of binge PAE, wherein pregnant C57Bl/6J females received 3 g/kg alcohol (ETOH) daily from gestational day 12.5 to 17.5; maltodextrin (MD) and medium chain triglycerides (MCT) served as isocaloric nutritional controls, and sham (H2O) treatment controlled for gavage stress. Our comprehensive assessment quantified body composition, energy expenditure, glucose tolerance, and cardiovascular function in offspring at age 17 weeks. Although ETOH pups were initially lighter than all other groups, they did not have a unique obesogenic phenotype. Instead, a similar obesogenic phenotype emerged in all three caloric groups (MCT, MD, ETOH), such that caloric groups had greater post-weaning weight gain (both sexes), reduced gonadal fat weight (males), and reduced glucose clearance (males) compared against H2O offspring. PAE did not affect body composition, respiratory exchange ratio, metabolic adaption to high-fat or low-fat diet, eating behavior, and blood pressure, and ETOH values did not differ from those obtained from isocaloric controls. Exposure to a higher alcohol dose (4.5 g/kg) or a high-fat (60%) diet did not exacerbate differences in body composition or glucose tolerance. "PAE-specific" effects on postnatal growth, glucose tolerance, adiposity, or hypertension only emerged when PAE offspring were compared just against H2O controls, or against MD controls. We conclude that prior reports of obesity and glucose intolerance in adult PAE offspring reflect the contribution of added gestational calories, and not alcohol's pharmacologic action. Results suggest that the increased adiposity risk in FASD is not caused by metabolic reprogramming, and instead originates from behavioral, medication, and/or dietary practices. This study highlights the importance of appropriate dietary controls in nutritional studies of PAE.
C1 [Amos-Kroohs, Robyn M.; Smith, Susan M.] Univ N Carolina, UNC Nutr Res Inst, Kannapolis, NC 28223 USA.
   [Amos-Kroohs, Robyn M.; Smith, Susan M.] Univ N Carolina, Dept Nutr, Kannapolis, NC 28223 USA.
   [Amos-Kroohs, Robyn M.; Nelson, David W.; Yen, Chi-Liang Eric; Smith, Susan M.] Univ Wisconsin, Dept Nutr Sci, 1415 Linden Dr, Madison, WI 53706 USA.
   [Hacker, Timothy A.] Univ Wisconsin, Dept Med, Cardiovasc Res Ctr, Sch Med & Publ Hlth, Madison, WI USA.
C3 University of North Carolina; University of North Carolina Chapel Hill;
   University of North Carolina; University of Wisconsin System; University
   of Wisconsin Madison; University of Wisconsin System; University of
   Wisconsin Madison
RP Smith, SM (corresponding author), Univ N Carolina, UNC Nutr Res Inst, Kannapolis, NC 28223 USA.; Smith, SM (corresponding author), Univ N Carolina, Dept Nutr, Kannapolis, NC 28223 USA.; Smith, SM (corresponding author), Univ Wisconsin, Dept Nutr Sci, 1415 Linden Dr, Madison, WI 53706 USA.
EM Susan_Smith@unc.edu
OI Smith, Susan M/0000-0003-4782-6857
FU National Institute on Alcohol Abuse and Alcoholism [R01 AA22999, R37
   AA11085, F32 AA0024364]; National Institute of Diabetes and Digestive
   and Kidney Disorders [T32 DK007665, R01 DK88210]; Vilas Associate Award
   from the University of Wisconsin-Madison
FX This research was supported by Awards R01 AA22999 (SMS), R37 AA11085
   (SMS), and F32 AA0024364 (RMAK) from the National Institute on Alcohol
   Abuse and Alcoholism; T32 DK007665 (RMAK) and R01 DK88210 (CEY) from the
   National Institute of Diabetes and Digestive and Kidney Disorders; and a
   Vilas Associate Award from the University of Wisconsin-Madison (SMS).
   The funders had no role in study design, data collection and analysis,
   decision to publish, or preparation of the manuscript.
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NR 57
TC 16
Z9 16
U1 0
U2 11
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JUN 28
PY 2018
VL 13
IS 6
AR e0199213
DI 10.1371/journal.pone.0199213
PG 24
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA GL0GK
UT WOS:000436645400018
PM 29953483
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Oi, M
   Donner, D
   Peart, J
   Beck, B
   Wendt, L
   Headrick, JP
   du Toit, EF
AF Oi, Massa
   Donner, Daniel
   Peart, Jason
   Beck, Belinda
   Wendt, Lauren
   Headrick, John P.
   du Toit, Eugene F.
TI Pravastatin improves risk factors but not ischaemic tolerance in obese
   rats
SO EUROPEAN JOURNAL OF PHARMACOLOGY
LA English
DT Article
DE Statins; Ischaemia-reperfusion; Myocardial Infarction; Obesity;
   Reperfusion Injury; Mitochondrial dynamics
ID HIGH-FAT DIET; INSULIN-RESISTANCE; MYOCARDIAL-INFARCTION; MITOCHONDRIAL
   FISSION; STATIN THERAPY; CARDIOVASCULAR-DISEASE; REPERFUSION INJURY;
   METABOLIC SYNDROME; OXIDATIVE STRESS; ATORVASTATIN
AB Statins are effective in management of dyslipidaemia, and a cornerstone of CVD prevention strategies. However, the impacts of their pleiotropic effects on other cardiovascular risk factors and myocardial responses to infarction are not well characterised. We hypothesised that pravastatin treatment in obesity improves lipid profiles, insulin-resistance and myocardial resistance to ischaemia/reperfusion (I/R) injury. Wistar rats were fed a control (C) chow or high carbohydrate and fat diet (HCFD) for 16 weeks with vehicle or pravastatin (prava 7.5 mg/kg/day) treatment for 8 weeks. At 16 weeks HOMAs were performed, blood samples collected and hearts excised for Langendorff perfusions/biochemical analyses. Anti-oxidant activity and proteins regulating mitochondrial fission/fusion and apoptosis were assessed. The HCFD increased body weight (736 +/- 15 vs. 655 +/- 12 g for C; P < 0.001), serum triglycerides (2.91 +/- 0.52 vs. 1.64 +/- 0.26 mmol/L for C; P < 0.001) and insulin-resistance (HOMA-6.9 +/- 0.8 vs. 4.2 +/- 0.5 for C; P < 0.05) while prava prevented diet induced changes and paradoxically increased lipid peroxidation. The HCFD increased infarct size (34.1 +/- 3.1% vs. 18.8 +/- 3.0% of AAR for C; P < 0.05), which was unchanged by prava in C and HCFD animals. The HCFD decreased cardiac TxR activity and mitochondrial MFN-1 and increased mitochondrial DRP-1 (reducing MFN-1: DRP-1 ratio) and Bax expression, with the latter changes prevented by prava. While unaltered by diet, cytosolic levels of Bax and caspase-3 were reduced by prava in C and HCFD hearts (without changes in cleaved caspase-3). We conclude that obesity, hyper-triglyceridemia and impaired glycemic control in HCFD rats are countered by prava. Despite improved risk factors, prava did not reduce myocardial infarct size, potentially reflecting its complex pleiotropic impacts on cardiac GPX activity and MFN-1, DRP-1, caspase-3 and Bcl-2 proteins.
C1 [Oi, Massa; Donner, Daniel; Peart, Jason; Wendt, Lauren; Headrick, John P.; du Toit, Eugene F.] Griffith Univ Gold Coast, Sch Med Sci, Southport, Qld 4222, Australia.
   [Beck, Belinda] Griffith Univ Gold Coast, Menzies Hlth Inst Queensland, Sch Allied Hlth Sci, Southport, Qld 4222, Australia.
C3 Griffith University; Griffith University - Gold Coast Campus; Griffith
   University; Griffith University - Gold Coast Campus
RP du Toit, EF (corresponding author), Griffith Univ, Sch Med Sci, Southport, Qld 4222, Australia.
EM j.dutoit@griffith.edu.au
RI Beck, Belinda/B-9079-2008
OI Donner, Daniel G./0000-0003-4924-720X; Beck, Belinda/0000-0003-1295-6395
FU Griffith University; Griffith Health Institute
FX This study was supported by funds from the Griffith University Research
   Grant scheme and the Griffith Health Institute. We wish to thank Owain
   Evans for his technical assistance with the TrxR and GPX activity
   assays.
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NR 84
TC 10
Z9 11
U1 0
U2 17
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0014-2999
EI 1879-0712
J9 EUR J PHARMACOL
JI Eur. J. Pharmacol.
PD MAY 5
PY 2018
VL 826
BP 148
EP 157
DI 10.1016/j.ejphar.2018.02.050
PG 10
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA GA3UL
UT WOS:000428255000018
PM 29501869
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Neale, EP
   Tapsell, LC
   Guan, V
   Batterham, MJ
AF Neale, Elizabeth P.
   Tapsell, Linda C.
   Guan, Vivienne
   Batterham, Marijka J.
TI The effect of nut consumption on markers of inflammation and endothelial
   function: a systematic review and meta-analysis of randomised controlled
   trials
SO BMJ OPEN
LA English
DT Review
ID C-REACTIVE PROTEIN; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   CARDIOVASCULAR-DISEASE; MEDITERRANEAN DIET; RISK-FACTORS; WEIGHT-LOSS;
   ALMOND CONSUMPTION; OXIDATIVE STRESS; BODY-COMPOSITION
AB Objectives To examine the effect of nut consumption on inflammatory biomarkers and endothelial function.
   Design A systematic review and meta-analysis.
   Data sources MEDLINE, PubMed, Cumulative Index to Nursing and Allied Health Literature and Cochrane Central Register of Controlled Trials (all years to 13 January 2017).
   Eligibility criteria Randomised controlled trials (with a duration of 3 weeks or more) or prospective cohort designs conducted in adults; studies assessing the effect of consumption of tree nuts or peanuts on C-reactive protein (CRP), adiponectin, tumour necrosis factor alpha, interleukin-6, intercellular adhesion molecule 1, vascular cell adhesion protein 1 and flow-mediated dilation (FMD).
   Data extraction and analysis Relevant data were extracted for summary tables and analyses by two independent researchers. Random effects meta-analyses were conducted to explore weighted mean differences (WMD) in change or final mean values for each outcome.
   Results A total of 32 studies (all randomised controlled trials) were included in the review. The effect of nut consumption on FMD was explored in nine strata from eight studies (involving 652 participants), with consumption of nuts resulting in significant improvements in FMD (WMD: 0.79%(95% CI 0.35 to 1.23)). Nut consumption resulted in small, non-significant differences in CRP (WMD: -0.01 mg/L (95% CI -0.06 to 0.03)) (26 strata from 25 studies), although sensitivity analyses suggest results for CRP may have been influenced by two individual studies. Small, non-significant differences were also found for other biomarkers of inflammation.
   Conclusions This systematic review and metaanalysis of the effects of nut consumption on inflammation and endothelial function found evidence for favourable effects on FMD, a measure of endothelial function.
   Non-significant changes in other biomarkers indicate a lack of consistent evidence for effects of nut consumption on inflammation. The findings of this analysis suggest a need for more research in this area, with a particular focus on randomised controlled trials.
   PROSPERO registration number CRD42016045424.
C1 [Neale, Elizabeth P.; Tapsell, Linda C.; Guan, Vivienne] Univ Wollongong, Fac Sci Med & Hlth, Sch Med, Wollongong, NSW, Australia.
   [Neale, Elizabeth P.; Tapsell, Linda C.] Univ Wollongong, Illawarra Hlth & Med Res Inst, Wollongong, NSW, Australia.
   [Batterham, Marijka J.] Univ Wollongong, Fac Engn & Informat Sci, Stat Consulting Serv, Sch Math & Appl Stat, Wollongong, NSW, Australia.
C3 University of Wollongong; Illawarra Health & Medical Research Institute;
   University of Wollongong; University of Wollongong
RP Neale, EP (corresponding author), Univ Wollongong, Fac Sci Med & Hlth, Sch Med, Wollongong, NSW, Australia.; Neale, EP (corresponding author), Univ Wollongong, Illawarra Hlth & Med Res Inst, Wollongong, NSW, Australia.
EM elizan@uow.edu.au
RI Guan, Vivienne/R-1292-2019; Neale, Elizabeth/H-8514-2019; batterham,
   marijka/IQV-9028-2023
OI Guan, Vivienne/0000-0002-3162-1788; Tapsell, Linda/0000-0002-2546-6507;
   Batterham, Marijka/0000-0002-9520-6508
FU INC International Nut and Dried Fruit Council [2016-R02]
FX This study was supported by the INC International Nut and Dried Fruit
   Council (2016-R02)
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NR 76
TC 83
Z9 87
U1 0
U2 15
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2044-6055
J9 BMJ OPEN
JI BMJ Open
PD NOV
PY 2017
VL 7
IS 11
AR e016863
DI 10.1136/bmjopen-2017-016863
PG 14
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA FT1MA
UT WOS:000422898800063
PM 29170286
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Hoffman, JB
   Petriello, MC
   Hennig, B
AF Hoffman, Jessie B.
   Petriello, Michael C.
   Hennig, Bernhard
TI Impact of nutrition on pollutant toxicity: an update with new insights
   into epigenetic regulation
SO REVIEWS ON ENVIRONMENTAL HEALTH
LA English
DT Review
ID PERSISTENT ORGANIC POLLUTANTS; TRIMETHYLAMINE-N-OXIDE; ENDOTHELIAL-CELL
   INFLAMMATION; POLYUNSATURATED FATTY-ACIDS; POLYCHLORINATED-BIPHENYLS;
   GLUCOSE-HOMEOSTASIS; OXIDATIVE STRESS; HEALTH-BENEFITS; GUT MICROBIOTA;
   HEART-DISEASE
AB Exposure to environmental pollutants is a global health problem and is associated with the development of many chronic diseases, including cardiovascular disease, diabetes and metabolic syndrome. There is a growing body of evidence that nutrition can both positively and negatively modulate the toxic effects of pollutant exposure. Diets high in proinflammatory fats, such as linoleic acid, can exacerbate pollutant toxicity, whereas diets rich in bioactive and anti-inflammatory food components, including omega-3 fatty acids and polyphenols, can attenuate toxicant-associated inflammation. Previously, researchers have elucidated direct mechanisms of nutritional modulation, including alteration of nuclear factor kappa-lightchain-enhancer of activated B cells (NF-kB) signaling, but recently, increased focus has been given to the ways in which nutrition and pollutants affect epigenetics. Nutrition has been demonstrated to modulate epigenetic markers that have been linked either to increased disease risks or to protection against diseases. Overnutrition (i.e. obesity) and undernutrition (i. e. famine) have been observed to alter prenatal epigenetic tags that may increase the risk of offspring developing disease later in life. Conversely, bioactive food components, including curcumin, have been shown to alter epigenetic markers that suppress the activation of NF-.B, thus reducing inflammatory responses. Exposure to pollutants also alters epigenetic markers and may contribute to inflammation and disease. It has been demonstrated that pollutants, via epigenetic modulations, can increase the activation of NF-.B and upregulate microRNAs associated with inflammation, cardiac injury and oxidative damage. Importantly, recent evidence suggests that nutritional components, including epigallocatechin gallate (EGCG), can protect against pollutant-induced inflammation through epigenetic regulation of -proinflammatory target genes of NF-.B. Further research is needed to better understand how nutrition can modulate pollutant toxicity through epigenetic regulation. Therefore, the objective of this review is to elucidate the current evidence linking epigenetic changes to pollutant-induced diseases and how this regulation may be modulated by nutrients allowing for the development of future personalized lifestyle interventions.
C1 [Hoffman, Jessie B.; Petriello, Michael C.; Hennig, Bernhard] Univ Kentucky, Superfund Res Ctr, 900 S Limestone St, Lexington, KY 40536 USA.
   [Petriello, Michael C.; Hennig, Bernhard] Univ Kentucky, Coll Agr Food & Environm, Dept Anim & Food Sci, Lexington, KY 40536 USA.
   [Hoffman, Jessie B.] Univ Kentucky, Coll Med, Dept Pharmacol & Nutr Sci, Lexington, KY 40536 USA.
C3 University of Kentucky; University of Kentucky; University of Kentucky
RP Hennig, B (corresponding author), Univ Kentucky, Superfund Res Ctr, 900 S Limestone St, Lexington, KY 40536 USA.; Hennig, B (corresponding author), Univ Kentucky, Coll Agr Food & Environm, Dept Anim & Food Sci, Lexington, KY 40536 USA.
EM bhennig@uky.edu
FU National Institute of Environmental Health Sciences at the National
   Institutes of Health [P42ES007380]; University of Kentucky Agricultural
   Experiment Station
FX This work was supported by the National Institute of Environmental
   Health Sciences at the National Institutes of Health [P42ES007380], and
   the University of Kentucky Agricultural Experiment Station.
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NR 83
TC 18
Z9 21
U1 0
U2 24
PU WALTER DE GRUYTER GMBH
PI BERLIN
PA GENTHINER STRASSE 13, D-10785 BERLIN, GERMANY
SN 0048-7554
EI 2191-0308
J9 REV ENVIRON HEALTH
JI Rev. Environ. Health
PD MAR
PY 2017
VL 32
IS 1-2
SI SI
BP 65
EP 72
DI 10.1515/reveh-2016-0041
PG 8
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA EN5GJ
UT WOS:000396033300010
PM 28076319
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Yao, X
   Tian, Z
AF Yao, Xu
   Tian, Zhong
TI Dyslipidemia and colorectal cancer risk: a meta-analysis of prospective
   studies
SO CANCER CAUSES & CONTROL
LA English
DT Article
DE Cancer prevention; Colorectal neoplasms; Dyslipidemia; Epidemiology
ID NUTRITION EXAMINATION SURVEY; C-REACTIVE PROTEIN; DOSE-RESPONSE DATA;
   METABOLIC SYNDROME; SERUM-CHOLESTEROL; OXIDATIVE STRESS;
   NATIONAL-HEALTH; HEART-DISEASE; US ADULTS; FOLLOW-UP
AB The findings from epidemiologic studies of dyslipidemia and colorectal cancer risk have been conflicting. We performed a dose-response meta-analysis of published prospective studies to assess the aforementioned association.
   Relevant studies that reported the association between the components of dyslipidemia (serum triglyceride, total cholesterol, and high-/low-density lipoprotein cholesterol) and colorectal cancer risk were identified by searching PubMed until the end of May 2014. We pooled the relative risks (RRs) from individual studies using a random- and fixed-effects models and performed dose-response, heterogeneity, and publication bias analyses.
   Seventeen prospective studies, including 1,987,753 individuals with 10,876 colorectal cancer events, were included in the meta-analysis. The overall pooled RR for high versus low concentrations for triglyceride (n = 9 studies) was 1.18 (95 % CI 1.04-1.34; I (2) = 47.8 %), for total cholesterol (n = 10 studies) was 1.11 (95 % CI 1.01-1.21; I (2) = 46.7 %), for high-density lipoprotein cholesterol (n = 6 studies) was 0.84 (95 % CI 0.69-1.02; I (2) = 42.5 %), and for low-density lipoprotein cholesterol (n = 3 studies) was 1.04 (95 % CI 0.60-1.81; I (2) = 82.7 %). In the dose-response analysis, the overall pooled RR was 1.01 (95 % CI 1.00-1.03; I (2) = 0 %) per 50 mg/dL of triglyceride and 1.01 (95 % CI 0.97-1.05; I (2) = 64.3 %) per 100 mg/dL of total cholesterol.
   This meta-analysis of prospective studies suggests that dyslipidemia, especially high levels of serum triglyceride and total cholesterol, is associated with an increased risk of colorectal cancer, whereas high-density lipoprotein cholesterol might associate with a decreased risk of colorectal cancer. Further studies are warranted to determine whether altering the concentrations of these metabolic variables may reduce colorectal cancer risk.
C1 [Yao, Xu; Tian, Zhong] China Med Univ, Shengjing Hosp, Dept Gen Surg, Shenyang 110004, Liaoning, Peoples R China.
C3 China Medical University
RP Tian, Z (corresponding author), China Med Univ, Shengjing Hosp, Dept Gen Surg, 36 San Hao St, Shenyang 110004, Liaoning, Peoples R China.
EM zhongt_sjhospital@126.com
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NR 62
TC 95
Z9 101
U1 1
U2 18
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0957-5243
EI 1573-7225
J9 CANCER CAUSE CONTROL
JI Cancer Causes Control
PD FEB
PY 2015
VL 26
IS 2
BP 257
EP 268
DI 10.1007/s10552-014-0507-y
PG 12
WC Oncology; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Public, Environmental & Occupational Health
GA AZ4IF
UT WOS:000348184100010
PM 25488827
DA 2025-06-11
ER

PT J
AU Morel, O
   Luca, F
   Grunebaum, L
   Jesel, L
   Meyer, N
   Desprez, D
   Robert, S
   Dignat-George, F
   Toti, F
   Simon, C
   Goichot, B
AF Morel, O.
   Luca, F.
   Grunebaum, L.
   Jesel, L.
   Meyer, N.
   Desprez, D.
   Robert, S.
   Dignat-George, F.
   Toti, F.
   Simon, C.
   Goichot, B.
TI Short-term very low-calorie diet in obese females improves the
   haemostatic balance through the reduction of leptin levels, PAI-1
   concentrations and a diminished release of platelet and
   leukocyte-derived microparticles
SO INTERNATIONAL JOURNAL OF OBESITY
LA English
DT Article
DE apoptosis; thrombosis; endothelium; leukocyte; metabolic syndrome;
   coagulation
ID CIRCULATING PROCOAGULANT MICROPARTICLES; PLASMINOGEN-ACTIVATOR
   INHIBITOR; INSULIN-RESISTANCE; TISSUE FACTOR; CORONARY-ARTERY;
   WEIGHT-LOSS; IN-VIVO; THROMBOSIS; ELEVATION; DYSFUNCTION
AB Background: In obesity, metabolic stress and inflammation in injured tissues could favour enhanced shedding of procoagulant microparticles (MPs). At sites of endothelium injury, the swift recruitment of procoagulant leukocyte-derived MPs enables the initiation of blood coagulation and thrombus growth.
   Objectives: In obese females, we sought to evaluate the impact of a very low-calorie diet (VLCD) on procoagulant MP levels, fibrinolytic status, inflammation and endothelium damage.
   Methods: Circulating biomarkers of vascular damage, fibrinolytic status, platelet activation and inflammation were measured before, 30 and 90 days after starting a short-term VLCD. MPs were measured by flow cytometry and capture assays. Their procoagulant potential was quantified using functional prothrombinase assays and their cellular origin were determined using flow cytometry (endothelium, platelet, leukocyte, lymphocyte and erythrocyte-derived MP) or capture assays.
   Results: A total of 24 obese females (39 +/- 10 years) with a mean body mass index of 35 +/- 4 kg m(-2) were prospectively enroled. Procoagulant leukocyte-derived MPs were associated with the waist circumference at baseline (r = 0.534; P = 0.010) and at 90 days follow-up (r = 0.487; P = 0.021). At 90 days, weight reduction (-9.8%) was associated with a lowering of blood pressure, improvement of metabolic parameters and a significant reduction of plasminogen activator inhibitor-1 (PAI-1) (-38%), procoagulant platelet-derived MPs (-43%), leukocyte-derived MPs (-28%) and leptin (-32%) levels.
   Conclusion: In obese females, a short-term VLCD results in an overall improvement of the haemostatic balance characterized by the reduction of PAI-levels, diminished release of platelet and leukocyte-derived MPs and a reduction in leptin levels, an adipocyte-derived cytokine. International Journal of Obesity (2011) 35, 1479-1486; doi:10.1038/ijo.2011.19; published online 8 March 2011
C1 [Morel, O.; Jesel, L.] Univ Strasbourg, Nouvel Hop Civil, Hop Univ Strasbourg, F-67091 Strasbourg, France.
   [Morel, O.; Toti, F.] Univ Strasbourg, Fac Med, Inst Hematol & Immunol, F-67091 Strasbourg, France.
   [Morel, O.; Toti, F.] INSERM, U770, F-94275 Le Kremlin Bicetre, France.
   [Grunebaum, L.; Desprez, D.] CHU Hautepierre, Hop Univ, Dept Hemostase, F-67098 Strasbourg, France.
   [Meyer, N.] Univ Strasbourg, Fac Med, Dept Biostat, F-67091 Strasbourg, France.
   [Robert, S.; Dignat-George, F.] Univ Mediterranee, Fac Pharm, Marseille, France.
   [Toti, F.] Univ Paris 11, Fac Med Paris Sud, Paris, France.
   [Simon, C.] Univ Lyon, INSERM, INRA U870, U1235,CRNH Rhone Alpes,Hosp Civils Lyon, Oullins, France.
C3 CHU Strasbourg; Universites de Strasbourg Etablissements Associes;
   Universite de Strasbourg; Universites de Strasbourg Etablissements
   Associes; Universite de Strasbourg; Institut National de la Sante et de
   la Recherche Medicale (Inserm); CHU Strasbourg; Universites de
   Strasbourg Etablissements Associes; Universite de Strasbourg;
   Aix-Marseille Universite; Universite Paris Saclay; Universite Claude
   Bernard Lyon 1; INRAE; CHU Lyon; Institut National de la Sante et de la
   Recherche Medicale (Inserm)
RP Morel, O (corresponding author), Univ Strasbourg, Nouvel Hop Civil, Hop Univ Strasbourg, Pl Hop, F-67091 Strasbourg, France.
EM olivier.morel@chru-strasbourg.fr
RI , simon/B-2895-2011; Goichot, Bernard/MGW-7323-2025; DIGNAT-GEORGE,
   Francoise/R-1129-2016
OI Morel, Olivier/0000-0002-7295-3041; DIGNAT-GEORGE,
   Francoise/0000-0001-7006-4462
FU PHRC (Programme Hospitalier de Recherche Clinique)
FX This work was supported by the PHRC (Programme Hospitalier de Recherche
   Clinique) regional. VLCD was provided by Insudiet (ZI du Taillis, BP
   10006, 49270 Champtoceaux, France). The authors thank Drs Caneva, Perrin
   and Busch and the dieticians for the clinical supervision of the
   patients and Dr F McKenna for careful english editing.
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NR 41
TC 43
Z9 43
U1 0
U2 4
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0307-0565
EI 1476-5497
J9 INT J OBESITY
JI Int. J. Obes.
PD DEC
PY 2011
VL 35
IS 12
BP 1479
EP 1486
DI 10.1038/ijo.2011.19
PG 8
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 866VP
UT WOS:000298414500004
PM 21386797
DA 2025-06-11
ER

PT J
AU Musso, G
   Gambino, R
   Cassader, M
AF Musso, Giovanni
   Gambino, Roberto
   Cassader, Maurizio
TI Lipoprotein metabolism mediates the association of MTP polymorphism with
   β-cell dysfunction in healthy subjects and in nondiabetic normolipidemic
   patients with nonalcoholic steatohepatitis
SO JOURNAL OF NUTRITIONAL BIOCHEMISTRY
LA English
DT Article
DE Microsomal triglyceride transfer protein, VLDL subfractions,
   Postprandial; beta-cell, Disposition index, ApoB48; Oxidized LDL
ID TRIGLYCERIDE TRANSFER PROTEIN; LOW-DENSITY-LIPOPROTEIN; FATTY
   LIVER-DISEASE; ALANINE AMINOTRANSFERASE; INSULIN SENSITIVITY; TYPE-2;
   GENE; RISK; HUMANS
AB Nonalcoholic steatohepatitis (NASH) predicts incident diabetes independently of insulin resistance, adiposity and metabolic syndrome through unclear mechanisms. Dietary fat consumption and lipoperoxidative stress predispose to diabetes in the general population and to liver injury in NASH. Microsomal triglyceride transfer protein (MTP) polymorphism modulates lipoprotein metabolism in the general population and liver disease in NASH; a functional MTP polymorphism recently predicted incident diabetes independently of insulin resistance in the general population We simultaneously assessed the impact of MTP polymorphism, diet, adipokines and lipoprotein metabolism, on glucose homeostasis in NASH.
   MTP -493G/T polymorphism, dietary habits, adipokines and postprandial triglyceride-rich lipoproteins, high-density lipoprotein cholesterol (HDL-C) and oxidized low-density lipoprotein (oxLDL) responses to an oral fat load, were cross-sectionally correlated to oral glucose tolerance test- and frequently sampled intravenous glucose tolerance test-derived Minimal Model Indexes of glucose homeostasis in 40 nondiabetic normolipidemic patients with NASH and 40 age-, sex- and body mass index-matched healthy controls. Despite comparable insulin resistance, fasting lipids, adipokines and dietary habits, MTP GG genotype had significantly more severe beta-cell dysfunction, higher plasma Tg. FFA, intestinal and hepatic very low-density lipoprotein 1 subtractions and oxLDL responses and deeper HDL-C fall than GT/TT carriers in patients and controls
   Postprandial HDL-C and oxLDL responses independently predicted dysfunction and mediated the effect of MTP polymorphism on beta-cell function
   In nondiabetic normolipidemic NASH, MTP -493G/T polymorphism modulates beta-cell function, an effect mediated by postprandial HDL-C and oxLDL metabolism. The impact of this polymorphism on the risk of diabetes and the efficacy of lipid-lowering therapies in restoring beta-cell function in NASH, even with normal fasting lipid values, warrant further investigation (C) 2010 Elsevier Inc. All rights reserved.
C1 [Musso, Giovanni] Gradenigo Hosp, I-10132 Turin, Italy.
   [Gambino, Roberto; Cassader, Maurizio] Univ Turin, Dept Internal Med, I-10124 Turin, Italy.
C3 Humanitas Hospital Gradenigo; University of Turin
RP Musso, G (corresponding author), Gradenigo Hosp, I-10132 Turin, Italy.
RI Musso, Giovanni/AAB-7884-2022; GAMBINO, Roberto/AAC-7517-2022
FU Piedmont Region Funds Comitato Inter-ministeriale per la Programmazione
   Economica
FX No author has any conflict of interest to disclose. This work was partly
   funded by the Piedmont Region Funds Comitato Inter-ministeriale per la
   Programmazione Economica 2008.
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NR 30
TC 31
Z9 33
U1 0
U2 3
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0955-2863
EI 1873-4847
J9 J NUTR BIOCHEM
JI J. Nutr. Biochem.
PD SEP
PY 2010
VL 21
IS 9
BP 834
EP 840
DI 10.1016/j.jnutbio.2009.06.007
PG 7
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA 648RD
UT WOS:000281710700007
PM 19733470
DA 2025-06-11
ER

PT J
AU Theys, N
   Bouckenooghe, T
   Ahn, MT
   Remacle, C
   Reusens, B
AF Theys, Nicolas
   Bouckenooghe, Thomas
   Ahn, Marie-Therese
   Remacle, Claude
   Reusens, Brigitte
TI Maternal low-protein diet alters pancreatic islet mitochondrial function
   in a sex-specific manner in the adult rat
SO AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE
   PHYSIOLOGY
LA English
DT Article
DE developmental programming; malnutrition; metabolic syndrome; insulin
   secretion
ID STIMULATED INSULIN-SECRETION; LONG-TERM CHANGES; UNCOUPLING PROTEIN-2;
   GENE-EXPRESSION; GLUCOSE-HOMEOSTASIS; OXIDATIVE STRESS; SKELETAL-MUSCLE;
   REGULATORY ROLE; DNA MUTATIONS; BIRTH-WEIGHT
AB Theys N, Bouckenooghe T, Ahn M-T, Remacle C, Reusens B. Maternal low-protein diet alters pancreatic islet mitochondrial function in a sex-specific manner in the adult rat. Am J Physiol Regul Integr Comp Physiol 297: R1516-R1525, 2009. First published September 16, 2009; doi:10.1152/ajpregu.00280.2009.-Mitochondrial dysfunction may be a long-term consequence of a poor nutritional environment during early life. Our aim was to investigate whether a maternal low-protein (LP) diet may program mitochondrial dysfunction in islets of adult progeny before glucose intolerance ensues. To address this, pregnant Wistar rats were fed isocaloric diets containing either 20% protein (control) or 8% protein (LP diet) throughout gestation. From birth, offspring received the control diet. The mitochondrial function was analyzed in islets of 3-mo-old offspring. Related to their basal insulin release, cultured islets from both male and female LP offspring presented a lower response to glucose challenge and a blunted ATP production compared with control offspring. The expression of malate dehydrogenase as well as the subunit 6 of the ATP synthase encoded by mitochondrial genome (mtDNA) was lower in these islets, reducing the capacity of ATP production through the Krebs cycle and oxidative phosphorylation. However, mtDNA content was unchanged in LP islets compared with control. Several consequences of protein restriction during fetal life were more marked in male offspring. Only LP males showed an increased reactive oxygen species production associated with a higher expression of mitochondrial subunits of the electron transport chain NADH-ubiquinone oxireductase subunit 4L, an overexpression of peroxisome proliferator-activated receptor-gamma and uncoupling protein-2, and a strongly reduced beta-cell mass. In conclusion, mitochondrial function is clearly altered in islets from LP adult offspring in a sex-specific manner. That may provide a cellular explanation for the earlier development of glucose intolerance in male than in female offspring of dams fed an LP diet.
C1 [Theys, Nicolas; Bouckenooghe, Thomas; Ahn, Marie-Therese; Remacle, Claude; Reusens, Brigitte] Catholic Univ Louvain, Inst Life Sci, Cell Biol Lab, B-1348 Louvain, Belgium.
C3 Universite Catholique Louvain
RP Reusens, B (corresponding author), Pl Croix Sud,5 Box 2, B-1348 Louvain, Belgium.
EM brigitte.reusens@uclouvain.be
OI Bouckenooghe, Thomas/0000-0001-8872-8802
FU Parthenon Trust (London); European Project EARNEST
   [Food-CT-2005-007036]; Belgian Fonds National de la Recherche
   Scientifique; Fonds pour la Recherche dans l'Industrie et l'Agriculture
FX This work was supported by the Parthenon Trust (London), the European
   Project EARNEST (Food-CT-2005-007036, 6th Frame Programme), the Belgian
   Fonds National de la Recherche Scientifique, and Fonds pour la Recherche
   dans l'Industrie et l'Agriculture.
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NR 67
TC 77
Z9 83
U1 0
U2 13
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0363-6119
EI 1522-1490
J9 AM J PHYSIOL-REG I
JI Am. J. Physiol.-Regul. Integr. Comp. Physiol.
PD NOV
PY 2009
VL 297
IS 5
BP R1516
EP R1525
DI 10.1152/ajpregu.00280.2009
PG 10
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA 514CR
UT WOS:000271371900033
PM 19759337
DA 2025-06-11
ER

PT J
AU Johnston, CS
   Beezhold, BL
   Mostow, B
   Swan, PD
AF Johnston, Carol S.
   Beezhold, Bonnie L.
   Mostow, Bo
   Swan, Pamela D.
TI Plasma vitamin C is inversely related to body mass index and waist
   circumference but not to plasma adiponectin in nonsmoking adults
SO JOURNAL OF NUTRITION
LA English
DT Article
ID HUMAN ADIPOSE-TISSUE; OXIDATIVE STRESS; INSULIN-RESISTANCE;
   ASCORBIC-ACID; METABOLIC SYNDROME; SERUM ADIPONECTIN; FAT OXIDATION;
   WEIGHT-LOSS; OBESE; CARNITINE
AB We examined the relationships between plasma vita min C, adiposity, and the collagen-like adipokine, adiponectin. Of 118 sedentary, nonsmoking adults participating in the cross-sectional trial (35 men and 83 women aged 38.7 +/- 1.0 y with BMI of 30A +/- 0.6 kg/m(2), plasma vitamin C concentrations of 43.5 +/- 1.3 mu mol/L, and plasma adiponectin concentrations of 8.9 +/- 0.3 mg/L), 54% were obese and 24% were overweight. Plasma vitamin C was inversely related to BMI, percentage of body fat, and waist circumference in both women and men (r = -0.383 to -0.497, P < 0.025). In women but not men, these associations remained significant after controlling for body mass. Plasma vitamin C was directly related to plasma adiponectin in the women after controlling for age and vitamin C supplement use (r = 0.222, P = 0.049) but not after controlling for body mass. Twenty obese men and women participated in an intervention trial and consumed an energy-restricted diet low in vitamin C (approximate to 38 mg/d) for 8 wk. Subjects were stratified by age, gender, and BMI and randomly assigned to receive placebo or vitamin C (500 mg) capsules daily. At baseline, plasma adiponectin was directly related to plasma vitamin C (r = 0.609, P = 0.021) and inversely related to body mass (r = -0.785, P = 0.001). Body mass decreased significantly during the 8 wk study in both the vitamin C (n = 6, -5.9 +/- 0.9 kg) and placebo groups (n = 8, -6.5 +/- 0.7 kg). Plasma adiponectin increased 13% from baseline by wk 8 in both groups (P < 0.05). In summary, plasma vitamin C was inversely related to markers of adiposity, particularly in women, but vitamin C supplementation did not influence the circulating concentration of adiponectin.
C1 Arizona State Univ, Dept Nutr, Mesa, AZ 85212 USA.
   Arizona State Univ, Dept Exercise & Wellness, Mesa, AZ 85212 USA.
C3 Arizona State University; Arizona State University
RP Johnston, CS (corresponding author), Arizona State Univ, Dept Nutr, Mesa, AZ 85212 USA.
EM carol.johnston@asu.edu
RI Beezhold, Bonnie/ABE-5423-2020
OI Johnston, Carol/0000-0001-9540-6860
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NR 47
TC 81
Z9 93
U1 0
U2 7
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0022-3166
EI 1541-6100
J9 J NUTR
JI J. Nutr.
PD JUL
PY 2007
VL 137
IS 7
BP 1757
EP 1762
DI 10.1093/jn/137.7.1757
PG 6
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 189ET
UT WOS:000247972900009
PM 17585027
OA Bronze
DA 2025-06-11
ER

PT J
AU Quintanilla-García, CV
   Uribarri, J
   Fajardo-Araujo, ME
   Barrientos-Romero, JJ
   Romero-Gutiérrez, G
   Reynaga-Ornelas, MG
   Garay-Sevilla, ME
AF Quintanilla-Garcia, Claudia V.
   Uribarri, Jaime
   Fajardo-Araujo, Martha Eugenia
   Barrientos-Romero, Jose Juan
   Romero-Gutierrez, Gustavo
   Reynaga-Ornelas, Ma Guadalupe
   Garay-Sevilla, Ma Eugenia
TI Changes in circulating levels of carboxymethyllysine, soluble receptor
   for advanced glycation end products (sRAGE), and inflammation markers in
   women during normal pregnancy
SO JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
LA English
DT Article
DE N epsilon-carboxymethyllysine; sRAGE; physiological pregnancy
ID INSULIN-SENSITIVITY INDEX; METABOLIC SYNDROME; OXIDATIVE STRESS;
   PREECLAMPSIA; RISK; ENDPRODUCTS; RESISTANCE; DISEASE
AB Objective: To determine the circulating levels of insulin, N epsilon-carboxymethyllysine (CML), soluble receptor for advanced glycation end products (sRAGE), and markers of inflammation and oxidative stress (OS) in maternal and umbilical cord blood in a cohort of healthy women with normal pregnancy. Methods: We conducted an observational longitudinal study in a group of women (n = 31; age range 18-39 years) with healthy pregnancy starting at 30 weeks of gestation and finishing at the time of delivery. We collected weight and height in the participants and their neonates and calculated body mass index (BMI). Blood from each patient was collected at 30th week of pregnancy and at delivery when a sample of cord blood was also obtained. Glucose, lipid profile, CML, sRAGE, malondialdehyde (MDA), tumor necrosis factor-alpha (TNF-alpha), highly sensitivity C-reactive protein (hsPCR), and insulin were determined. The study was approved by the University of Guanajuato Institutional Ethics Committee. Results: All pregnancies reached term (mean gestational time 38.9 +/- 0.83 weeks) and there were no maternal complications. Mean age was 27.6 years. Lipid profile values were higher in the group compared with our values in nonpregnant women. During pregnancy, levels of insulin increased (p < .0006), CML (p < .0001) and sRAGE (p < .01) decreased, levels of MDA did not change, while those of TNF-alpha and hsPCR tended to increase. In the neonates, we found lower levels of CML (p < .003), hsPCR (p < .004), and insulin (p < .004) and higher levels of sRAGE (p < .013) and TNF-alpha (p < .022) compared to their mothers at delivery. In the total group, we found association of CML of the mother at baseline with the CML (p < .0006) and MDA (p < .002) in neonates, while maternal sRAGE at the end of pregnancy was associated with CML (p < .004) of their neonates. Conclusions: Our study confirms that normal pregnancy is accompanied by insulin resistance (IR) and significant increase in lipid profile, and demonstrates that circulating levels of CML and sRAGE decreased significantly at the end of pregnancy. The lack of association between the course of insulin levels and those of CML probably results from the predominant role of placental factors in the pathogenesis of IR in pregnancy. sRAGE levels in the neonates are markedly increased compared to their mothers suggesting a placental origin of this compound which may have a protective effect on the fetus since sRAGE restricts Advanced glycation end product (AGE) effects and may exert anti-inflammatory effects.
C1 [Quintanilla-Garcia, Claudia V.; Fajardo-Araujo, Martha Eugenia; Garay-Sevilla, Ma Eugenia] Dept Med Sci, Div Hlth Sci, Guanajuato, Mexico.
   [Uribarri, Jaime] Icahn Sch Med Mt Sinai, Dept Med, New York, NY 10029 USA.
   [Barrientos-Romero, Jose Juan] Maternal & Child Hosp, Leon, Guanajuato, Mexico.
   [Romero-Gutierrez, Gustavo] IMSS, Unit Ginecopediat UMAE 48, Leon, Guanajuato, Mexico.
   [Reynaga-Ornelas, Ma Guadalupe] Univ Guanajuato Campus, Dept Med & Nutr, Leon, Guanajuato, Mexico.
C3 Icahn School of Medicine at Mount Sinai
RP Garay-Sevilla, ME (corresponding author), Dept Med Sci, Div Hlth Sci, Guanajuato, Mexico.
EM marugaray_2000@yahoo.com
RI Uribarri, Jaime/ADX-7655-2022
OI Reynaga, Guadalupe/0000-0001-5698-7148; uribarri,
   jaime/0000-0001-9826-1134
FU DAIP-University of Guanajuato
FX The study was supported by DAIP-University of Guanajuato.
CR [Anonymous], ZANCO J MED SCI
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NR 38
TC 6
Z9 6
U1 0
U2 5
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1476-7058
EI 1476-4954
J9 J MATERN-FETAL NEO M
JI J. Matern.-Fetal Neonatal Med.
PD DEC 17
PY 2019
VL 32
IS 24
BP 4102
EP 4107
DI 10.1080/14767058.2018.1481948
PG 6
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA KS1UA
UT WOS:000518093900010
PM 29804482
DA 2025-06-11
ER

PT J
AU Gutierrez-Mariscal, FM
   Podadera-Herreros, A
   Alcalá-Diaz, JF
   Cardelo, MP
   Arenas-de Larriva, AP
   de la Cruz-ares, S
   Torres-Peña, JD
   Luque, RM
   Perez-Martinez, P
   Delgado-Lista, J
   Lopez-Miranda, J
   Yubero-Serrano, EM
AF Gutierrez-Mariscal, Francisco M.
   Podadera-Herreros, Alicia
   Alcala-Diaz, Juan F.
   Cardelo, Magdalena P.
   Arenas-de Larriva, Antonio P.
   de la Cruz-Ares, Silvia
   Torres-Pena, Jose D.
   Luque, Raul M.
   Perez-Martinez, Pablo
   Delgado-Lista, Javier
   Lopez-Miranda, Jose
   Yubero-Serrano, Elena M.
TI Reduction of circulating methylglyoxal levels by a Mediterranean diet is
   associated with preserved kidney function in patients with type 2
   diabetes and coronary heart disease: From the CORDIOPREV randomized
   controlled trial
SO DIABETES & METABOLISM
LA English
DT Article
DE Advanced glycation end products; Dietary strategy; Kidney function;
   Mediterranean diet; Methylglyoxal; Type 2 diabetes
ID GLYCATION END-PRODUCTS; LOW-FAT DIET; CARDIOVASCULAR-DISEASE;
   ANTIOXIDANT DEFENSES; METABOLIC SYNDROME; AGE RECEPTOR-1; CONSUMPTION;
   PREVENTION; STRESS; FOODS
AB Aim: Advanced glycation end products (AGEs) play a role in kidney disease in type 2 diabetes mellitus (T2DM). However, there have been no prior controlled clinical trials examining the effects of specific diets on AGE metabolism and their impact on kidney function. Our aim was to assess whether modulating AGE metabolism resulting in reduced AGEs levels, after consumption of two healthy diets, could delay kidney function decline in patients with T2DM and coronary heart disease (CHD).Methods: T2DM patients (540 out of 1002 patients from the CORDIOPREV study), with estimated glomerular filtration rate (eGFR) >= 30 ml/min/1.73 m(2), were classified based on their baseline kidney function: normal eGFR (>= 90 ml/min/1.73 m(2)), mildly decreased eGFR (60- < 90 ml/min/1.73 m(2)) and moderately decreased eGFR (<60 ml/min/1.73 m(2)). Serum AGE levels, methylglyoxal (MG) and N-carboximethyllysine (CML), and gene expression related to AGE metabolism (AGER1, RAGE, and GloxI mRNA) were measured before and after 5-years of dietary intervention (a Mediterranean diet or a low-fat diet).Results: Mediterranean diet produced a lower declined of eGFR compared to the low-fat diet only in patients with mildly decreased eGFR (P = 0.035). Moreover, Mediterranean diet was able to decrease MG levels and increase GloxI expression in normal and mildly decreased eGFR patients (all P < 0.05). One standard deviation increment of MG levels after dietary intervention resulted in a 6.8-fold (95 % CI 0.039;0.554) higher probability of eGFR decline.Conclusion: Our study showed that lowering circulating AGE levels, specifically MG, after following a Mediterranean diet, might be linked to the preservation of kidney function, evidenced by a decreased decline of eGFR in T2DM patients with CHD. Patients with mildly decreased eGFR could potentially benefit more from AGE reduction in maintaining kidney function.
C1 [Gutierrez-Mariscal, Francisco M.; Podadera-Herreros, Alicia; Alcala-Diaz, Juan F.; Cardelo, Magdalena P.; Arenas-de Larriva, Antonio P.; de la Cruz-Ares, Silvia; Torres-Pena, Jose D.; Perez-Martinez, Pablo; Delgado-Lista, Javier; Lopez-Miranda, Jose; Yubero-Serrano, Elena M.] Univ Cordoba, Reina Sofia Univ Hosp, Maimonides Inst Biomed Res Cordoba, Lipids & Atherosclerosis Unit,Unidad Gest Clin Med, Cordoba 14004, Spain.
   [Gutierrez-Mariscal, Francisco M.; Podadera-Herreros, Alicia; Alcala-Diaz, Juan F.; Cardelo, Magdalena P.; Arenas-de Larriva, Antonio P.; de la Cruz-Ares, Silvia; Torres-Pena, Jose D.; Luque, Raul M.; Perez-Martinez, Pablo; Delgado-Lista, Javier; Lopez-Miranda, Jose; Yubero-Serrano, Elena M.] Inst Hlth Carlos III, CIBER Physiopathol Obes & Nutr CIBEROBN, Madrid, Spain.
   [Luque, Raul M.] Univ Cordoba, Reina Sofia Univ Hosp, Maimonides Inst Biomed Res Cordoba, Dept Cell Biol Physiol & Immunol, Cordoba 14004, Spain.
   [Lopez-Miranda, Jose; Yubero-Serrano, Elena M.] Reina Sofia Univ Hosp, Lipids & Atherosclerosis Res Unit, IMIBIC, Avda Menendez Pidal S-N, Cordoba 14004, Spain.
C3 Universidad de Cordoba; CIBER - Centro de Investigacion Biomedica en
   Red; CIBEROBN; Universidad de Cordoba
RP Lopez-Miranda, J; Yubero-Serrano, EM (corresponding author), Reina Sofia Univ Hosp, Lipids & Atherosclerosis Res Unit, IMIBIC, Avda Menendez Pidal S-N, Cordoba 14004, Spain.
EM jlopezmir@uco.es; elena.yubero@imibic.org
RI Perez-Martinez, Pablo/AEL-6176-2022; de la Cruz Ares,
   Silvia/AAU-5933-2021; Gutierrez-Mariscal, Francisco M/AAX-3185-2021;
   Delgado-Lista, Javier/KAM-7412-2024; Arenas, Antonio/Y-9969-2019;
   YUBERO, ELENA/AFM-2738-2022; Peña, José/ABH-3312-2020; Alcala-Diaz,
   Juan/Q-4455-2019; Raul, Luque/M-6948-2018; Lopez-Miranda,
   Jose/Y-8306-2019; Pc, Maleni/Y-9987-2019; de la Cruz Ares,
   Silvia/L-7204-2017
OI de la Cruz Ares, Silvia/0000-0002-9013-228X; Alcala-Diaz, Juan
   Francisco/0000-0002-4572-3611; Lopez-Miranda, Jose/0000-0002-8844-0718;
   Delgado Lista, Francisco Javier/0000-0002-2982-2716; Podadera Herreros,
   Alicia/0000-0002-4555-4897
FU Fundacion Patrimonio Comunal Olivarero (Cordioprev-CEAS) [1/2016];
   Ministerio de Ciencia e Innovacion - MCIN/AEI [AGL2012-39615,
   AGL2015-67896-P, PID2019-104362RB-I00]; Consejeria de Salud-Junta de
   Andalucia [PC-0283-2017]; FIS [PI18/01822, PI21/00383]; Instituto de
   Salud Carlos III (ISCIII) of Spain; Directorate General for Assessment
   and Promotion of Research; EU's European Regional Development Fund
   (FEDER); Nicolas Monardes Programme from the "Servicio Andaluz de Salud,
   Junta de Andalucia", Spain [C1-0005-2019]
FX The CORDIOPREV study was supported by the Fundacion Patrimonio Comunal
   Olivarero (Cordioprev-CEAS, 1/2016 to Jose Lopez- Miranda). This study
   also received research grants from Ministerio de Ciencia e Innovacion
   (AGL2012-39615, AGL2015-67896-P and PID2019-104362RB-I00 funded by
   MCIN/AEI/1.0.13039/ 501100011033 to Jose Lopez-Miranda), from Consejeria
   de Salud-Junta de Andalucia (PC-0283-2017 to Elena M. Yubero-Serrano)
   and FIS (PI18/01822 and PI21/00383 to Elena M Yubero-Serrano),
   integrated into the framework of the National Plan for Scientific
   Research, Technological Development and Innovation 2013-2016,
   co-financed by the Instituto de Salud Carlos III (ISCIII) of Spain and
   also by the Directorate General for Assessment and Promotion of Research
   and the EU's European Regional Development Fund (FEDER). Elena M
   Yubero-Serrano was the recipient of the Nicolas Monardes Programme from
   the "Servicio Andaluz de Salud, Junta de Andalucia", Spain
   (C1-0005-2019). The funding bodies had no role in the study design, data
   collection and analysis, decision to publish, or preparation of the
   manuscript.
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NR 41
TC 6
Z9 6
U1 1
U2 13
PU MASSON EDITEUR
PI MOULINEAUX CEDEX 9
PA 21 STREET CAMILLE DESMOULINS, ISSY, 92789 MOULINEAUX CEDEX 9, FRANCE
SN 1262-3636
EI 1878-1780
J9 DIABETES METAB
JI Diabetes Metab.
PD JAN
PY 2024
VL 50
IS 1
AR 101503
DI 10.1016/j.diabet.2023.101503
EA DEC 2023
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA EF7J8
UT WOS:001137570600001
PM 38097011
OA hybrid
DA 2025-06-11
ER

PT J
AU Gelen, SU
   Ozkanlar, S
   Gedikli, S
   Atasever, M
AF Gelen, Sevda Urcar
   Ozkanlar, Seckin
   Gedikli, Semin
   Atasever, Mustafa
TI The investigation of the effects of monosodium glutamate on healthy rats
   and rats with STZ-induced diabetes
SO JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
LA English
DT Article
DE antioxidant; cytokine; diabetes mellitus; insulin; monosodium glutamate
ID OXIDATIVE STRESS; VITAMIN-E; DIET; INFLAMMATION; CYTOKINES; SYSTEM;
   MODEL; ASSAY
AB Monosodium glutamate (MSG, E621) is a flavor-enhancing food additive used widely in the food preparation industry and consumed regularly. It is considered that long-term consumption of MSG causes metabolic syndrome and obesity. Diabetes mellitus (DM) is a chronic metabolic disease characterized by high blood sugar, polyuria, polydipsia, and polyphagia, in which insulin secreted from pancreatic beta cells is inadequate for maintaining blood glucose homeostasis. Rats were application 65 mg/kg streptozotocin (STZ) solution intraperitoneally and a diabetes model was created. For this purpose, freshly prepared STZ was injected into the peritoneum. Tumor necrosis factor-alpha, interleukin (IL)-10, IL-6, and IL-1 beta levels in STZ, MSG, and STZ + MSG groups were found to be significantly increased in inflammation parameters measured on the 28th day of administration when compared to the Control Group (p < 0.001). Also, although malondialdehyde (MDA) levels increased significantly in the STZ + MSG group when compared to the control group (p < 0.001), glutathione (GSH), and superoxide dismutase (SOD) levels were significantly decreased in the STZ, MSG, and STZ + MSG groups when compared to the control group (p < 0.001). Also, although glucose levels increased significantly in STZ and STZ + MSG at the end of the 28th day (p < 0.01), insulin levels decreased in STZ, MSG, and STZ + MSG groups when compared to the control groups (p < 0.01). As a result, it was found that STZ and MSG application significantly increased cytokine production, increased MDA, which is an oxidant parameter in pancreatic tissue, and decreased antioxidants (GSH and SOD) when compared to the control groups. It was also found that MSG disrupted the normal histological structure in pancreatic cells, and the damage was much more in both exocrine and endocrine pancreatic areas in the STZ + MSG group when compared to the STZ and MSG groups. It was considered that with the increased use of MSG, the susceptibility to DM might increase along with tissue damage significantly in diabetic groups, therefore, MSG must be used in a limited and controlled manner.
C1 [Gelen, Sevda Urcar; Atasever, Mustafa] Ataturk Univ, Fac Vet Med, Dept Food Hyg & Technol, Erzurum, Turkiye.
   [Ozkanlar, Seckin] Ataturk Univ, Fac Vet Med, Dept Biochem, Erzurum, Turkiye.
   [Gedikli, Semin] Ataturk Univ, Fac Vet Med, Dept Histol & Embryol, Erzurum, Turkiye.
C3 Ataturk University; Ataturk University; Ataturk University
RP Gelen, SU (corresponding author), Ataturk Univ, Fac Vet Med, Dept Food Hyg & Technol, Erzurum, Turkiye.
EM surcar@atauni.edu.tr
RI gelen, sevda/AAR-2044-2020; Gedikli, Semin/AHB-0544-2022; atasever,
   mustafa/H-1018-2019
OI urcar gelen, sevda/0000-0002-1852-3614
FU Scientific Research Projects Coordination Unit of Ataturk University
   [TAB-2021-9373]
FX This study was supported financially by Scientific Research Projects
   Coordination Unit of Ataturk University (Project Grant No.
   TAB-2021-9373).
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NR 52
TC 2
Z9 2
U1 5
U2 12
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1095-6670
EI 1099-0461
J9 J BIOCHEM MOL TOXIC
JI J. Biochem. Mol. Toxicol.
PD JAN
PY 2024
VL 38
IS 1
DI 10.1002/jbt.23612
EA DEC 2023
PG 8
WC Biochemistry & Molecular Biology; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Toxicology
GA KA7U9
UT WOS:001123764000001
PM 38084638
OA hybrid
DA 2025-06-11
ER

PT J
AU Greff, D
   Juhász, AE
   Váncsa, S
   Váradi, A
   Sipos, Z
   Szinte, J
   Park, S
   Hegyi, P
   Nyirády, P
   Acs, N
   Várbíró, S
   Horváth, EM
AF Greff, Dorina
   Juhasz, Anna E. E.
   Vancsa, Szilard
   Varadi, Alex
   Sipos, Zoltan
   Szinte, Julia
   Park, Sunjune
   Hegyi, Peter
   Nyirady, Peter
   Acs, Nandor
   Varbiro, Szabolcs
   Horvath, Eszter M. M.
TI Inositol is an effective and safe treatment in polycystic ovary
   syndrome: a systematic review and meta-analysis of randomized controlled
   trials
SO REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
LA English
DT Review
DE Cycle length; Testosterone; Insulin; BMI; Metabolic syndrome; PCOS;
   Inositol; Metformin
ID D-CHIRO-INOSITOL; DOUBLE-BLIND; OXIDATIVE STRESS; MYOINOSITOL;
   METFORMIN; WOMEN; PARAMETERS; CRITERIA
AB BackgroundMetformin is the gold standard insulin sensitizer, which is widely used to treat insulin resistance in polycystic ovary syndrome (PCOS). However, metformin may induce gastrointestinal side effects.ObjectiveInositols have long been debated as a potential alternative for metformin in treating PCOS. Therefore, the present systematic review aimed to evaluate the efficacy and safety of inositols in treating PCOS.MethodsThe present systematic search was performed in CENTRAL, MEDLINE, and Embase from the inception until October 20th, 2021. Eligible randomized controlled trials (RCTs) included women diagnosed with PCOS and compared any inositols with metformin or placebo. Our primary outcome was cycle normalization, whereas secondary outcomes were body mass index (BMI), parameters of carbohydrate metabolism and clinical and laboratory hyperandrogenism. Results are reported as risk ratios or mean differences (MDs) with 95% confidence intervals (CIs).ResultsTwenty-six RCTs were identified, including data of 1691 patients (806 inositol, 311 with placebo, and 509 metformin groups). In patients treated with inositols, the risk (CI: 1.13; 2.85) of having a regular menstrual cycle was found by 1.79 higher than in the case of placebo. Moreover, the inositols showed non-inferiority compared to metformin in this outcome. In the case of BMI (MD = -0.45; CI: -0.89; -0.02), free testosterone (MD = -0,41, CI: -0.69; -0.13), total testosterone (MD = -20.39, CI: -40.12; -0.66), androstenedione (MD = -0.69, CI: -1,16; -0.22), glucose (MD = -3.14; CI: -5.75; -0.54) levels and AUC insulin (MD = -2081.05, CI: -2745.32; -1416.78) inositol treatment induced greater decrease compared to placebo. Inositol increased sex-hormone-binding globulin significantly compared to placebo (MD = 32.06, CI:1.27; 62.85).ConclusionInositol is an effective and safe treatment in PCOS. Moreover, inositols showed non-inferiority in most outcomes compared to the gold standard treatment; metformin.
C1 [Greff, Dorina; Juhasz, Anna E. E.; Vancsa, Szilard; Szinte, Julia; Park, Sunjune; Hegyi, Peter] Semmelweis Univ, Ctr Translat Med, Budapest, Hungary.
   [Greff, Dorina; Szinte, Julia; Acs, Nandor; Varbiro, Szabolcs] Semmelweis Univ, Dept Obstet & Gynecol, Ulloi Ut 78-A, H-1182 Budapest, Hungary.
   [Greff, Dorina; Szinte, Julia; Park, Sunjune; Horvath, Eszter M. M.] Semmelweis Univ, Dept Physiol, Budapest, Hungary.
   [Juhasz, Anna E. E.] Semmelweis Univ, Dept Dietet & Nutr Sci, Budapest, Hungary.
   [Vancsa, Szilard; Varadi, Alex; Sipos, Zoltan; Hegyi, Peter] Univ Pecs, Inst Translat Med, Szentagotha Res Ctr, Med Sch, Pecs, Hungary.
   [Vancsa, Szilard; Hegyi, Peter] Semmelweis Univ, Inst Pancreat Dis, Budapest, Hungary.
   [Nyirady, Peter] Semmelweis Univ, Dept Urol, Budapest, Hungary.
   [Varbiro, Szabolcs] Semmelweis Univ, Doctoral Sch, Workgrp Sci Management, Budapest, Hungary.
C3 Semmelweis University; Semmelweis University; Semmelweis University;
   Semmelweis University; University of Pecs; Semmelweis University;
   Semmelweis University; Semmelweis University
RP Várbíró, S (corresponding author), Semmelweis Univ, Dept Obstet & Gynecol, Ulloi Ut 78-A, H-1182 Budapest, Hungary.; Várbíró, S (corresponding author), Semmelweis Univ, Doctoral Sch, Workgrp Sci Management, Budapest, Hungary.
RI Vancsa, Szilard/HLP-7587-2023; Hegyi, Péter/B-3163-2016; Horvath,
   Eszter/I-9128-2017; Juhász, Anna Evelin/IAN-4300-2023; Acs,
   Nandor/I-4642-2019
OI Sipos, Zoltan/0000-0001-7845-8116; Juhasz, Anna
   Evelin/0000-0001-6946-045X
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NR 56
TC 56
Z9 61
U1 11
U2 35
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1477-7827
J9 REPROD BIOL ENDOCRIN
JI Reprod. Biol. Endocrinol.
PD JAN 26
PY 2023
VL 21
IS 1
AR 10
DI 10.1186/s12958-023-01055-z
PG 12
WC Endocrinology & Metabolism; Reproductive Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Reproductive Biology
GA 8K3OP
UT WOS:000923015500001
PM 36703143
OA gold, Green Published
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Niu, ZH
   Wu, QQ
   Luo, YG
   Wang, D
   Zheng, H
   Wu, YP
   Yang, XW
   Zeng, R
   Sun, L
   Lin, X
AF Niu, Zhenhua
   Wu, Qingqing
   Luo, Yaogan
   Wang, Di
   Zheng, He
   Wu, Yanpu
   Yang, Xiaowei
   Zeng, Rong
   Sun, Liang
   Lin, Xu
TI Plasma Lipidomic Subclasses and Risk of Hypertension in Middle-Aged and
   Elderly Chinese
SO PHENOMICS
LA English
DT Article
DE Hypertension; Lipidomic profiles; Phosphatidylethanolamines; Asian
   population
ID AT1-TYPE ANGIOTENSIN RECEPTOR; METABOLIC SYNDROME;
   CARDIOVASCULAR-DISEASE; INCIDENT HYPERTENSION; OXIDATIVE STRESS;
   BLOOD-PRESSURE; ATHEROGENESIS; DYSFUNCTION; OBESITY; PROFILE
AB While disrupted lipid metabolism is a well-established risk factor for hypertension in animal models, the links between various lipidomic signatures and hypertension in human studies remain unclear. We aimed to examine associations between plasma lipidomic profiles and prevalence of hypertension among 2248 community-living Chinese aged 50-70 years. Hypertension was defined according to 2020 International Society of Hypertension global hypertension practice guidelines and 2018 Chinese guidelines. In total, 728 plasma lipidomic species were profiled using high-coverage targeted lipidomics. After multivariate adjustment, including lifestyle, body mass index, blood lipids, and sodium intake, 110 metabolites from nine lipidomic subclasses showed significant associations with hypertension, among which phosphatidylethanolamines (PEs) had the strongest association. Eleven lipidomic signals for hypertension risk were further identified from the nine subclasses, including PE(18:0/18:2) (OR per SD, 1.49; 95% confidence intervals, 1.30-1.69), phosphatidylcholine (PC) (18:0/18:2) (1.27; 1.13-1.43), phosphatidylserine (18:0/18:0) (1.24; 1.09-1.41), lysophosphatidylinositol (18:1) (1.17; 1.06-1.29), triacylglycerol (52:5) (1.38; 1.18-1.61), diacylglycerol (16:0/18:2) (1.42; 1.19-1.69), dihydroceramide (24:0) (1.25; 1.09-1.43), hydroxyl-sphingomyelins (SM[2OH])C34:1 (1.19; 1.07-1.33), lysophosphatidylcholine (20:1) (0.86; 0.78-0.95), SM(OH)C38:1 (0.87; 0.79-0.96), and PC (18:2/20:1) (0.84; 0.75-0.94). Principal component analysis also showed that a factor mainly containing specific PEs was positively associated with hypertension (1.20; 1.09-1.33). Collectively, our study revealed that disturbances in multiple circulating lipidomic subclasses and signatures, especially PEs, were significantly associated with the prevalence of hypertension in middle-aged and elderly Chinese. Future studies are warranted to confirm our findings and determine the mechanisms underlying these associations.
C1 [Niu, Zhenhua; Luo, Yaogan; Wang, Di; Zheng, He; Wu, Yanpu; Yang, Xiaowei; Sun, Liang; Lin, Xu] Chinese Acad Sci, Univ Chinese Acad Sci, Shanghai Inst Nutr & Hlth, 320 Yue Yang Rd, Shanghai 200031, Peoples R China.
   [Wu, Qingqing; Zeng, Rong] Chinese Acad Sci, Shanghai Inst Biochem & Cell Biol, Ctr Excellence Mol Cell Sci, Shanghai 200031, Peoples R China.
   [Zeng, Rong; Lin, Xu] Chinese Acad Sci, Univ Chinese Acad Sci, Hangzhou Inst Adv Study, Key Lab Syst Biol, Hangzhou 310024, Peoples R China.
   [Zeng, Rong; Lin, Xu] Chinese Acad Sci, Univ Chinese Acad Sci, Hangzhou Inst Adv Study, Key Lab Syst Hlth Sci Zhejiang Prov, Hangzhou 310024, Peoples R China.
C3 Chinese Academy of Sciences; Shanghai Institute of Nutrition & Health,
   CAS; University of Chinese Academy of Sciences, CAS; Chinese Academy of
   Sciences; Center for Excellence in Molecular Cell Science, CAS; Chinese
   Academy of Sciences; University of Chinese Academy of Sciences, CAS;
   Chinese Academy of Sciences; University of Chinese Academy of Sciences,
   CAS
RP Sun, L; Lin, X (corresponding author), Chinese Acad Sci, Univ Chinese Acad Sci, Shanghai Inst Nutr & Hlth, 320 Yue Yang Rd, Shanghai 200031, Peoples R China.; Zeng, R (corresponding author), Chinese Acad Sci, Shanghai Inst Biochem & Cell Biol, Ctr Excellence Mol Cell Sci, Shanghai 200031, Peoples R China.; Zeng, R; Lin, X (corresponding author), Chinese Acad Sci, Univ Chinese Acad Sci, Hangzhou Inst Adv Study, Key Lab Syst Biol, Hangzhou 310024, Peoples R China.; Zeng, R; Lin, X (corresponding author), Chinese Acad Sci, Univ Chinese Acad Sci, Hangzhou Inst Adv Study, Key Lab Syst Hlth Sci Zhejiang Prov, Hangzhou 310024, Peoples R China.
EM zhniu@sibs.ac.cn; qqwu@sibs.ac.cn; ygluo@sibs.ac.cn; wangdi@sibs.ac.cn;
   zhenghe@sibs.ac.cn; wuyanpu2018@sibs.ac.cn; yangxiaowei2018@sibs.ac.cn;
   zr@sibs.ac.cn; sunliang@sibs.ac.cn; xlin@sibs.ac.cn
RI Zeng, Rong/P-2269-2017; yang, xiaowei/AAI-7847-2020; lin,
   xu/KOC-3517-2024
FU Strategic Priority CAS Project
FX We are grateful to Feijie Wang, Yiwei Ma, Quan Xiong, Shaofeng Huo, Huan
   Yun, Shuangshuang Chen, Boyu Song, Puchen Zhou, and Qianlu Jin of
   Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences
   for their kind assistance at various stages of this study. We especially
   acknowledge all the participants involved in this study.
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NR 48
TC 12
Z9 13
U1 1
U2 8
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 2730-583X
EI 2730-5848
J9 PHENOMICS
JI Phenomics
PD OCT
PY 2022
VL 2
IS 5
BP 283
EP 294
DI 10.1007/s43657-022-00057-y
PG 12
WC Genetics & Heredity
WE Emerging Sources Citation Index (ESCI)
SC Genetics & Heredity
GA CE0V3
UT WOS:001123463900003
PM 36939788
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Badri-Fariman, M
   Naeini, AA
   Mirzaei, K
   Moeini, A
   Hosseini, M
   Bagheri, SE
   Daneshi-Maskooni, M
AF Badri-Fariman, Mahtab
   Naeini, Amirmansour Alavi
   Mirzaei, Khadijeh
   Moeini, Ashraf
   Hosseini, Mostafa
   Bagheri, Seyedeh Elaheh
   Daneshi-Maskooni, Milad
TI Association between the food security status and dietary patterns with
   polycystic ovary syndrome (PCOS) in overweight and obese Iranian women:
   a case-control study
SO JOURNAL OF OVARIAN RESEARCH
LA English
DT Article
DE Food insecurity; Dietary patterns; Polycystic ovary syndrome; Obesity;
   Overweight
ID STOP HYPERTENSION DIET; INSULIN-RESISTANCE; PHYSICAL-ACTIVITY;
   RISK-FACTORS; METABOLIC SYNDROME; CARDIOVASCULAR-DISEASE; LIPID
   CONCENTRATIONS; OXIDATIVE STRESS; BODY-COMPOSITION; GLYCEMIC CONTROL
AB Background Polycystic ovary syndrome (PCOS), as one of the significant endocrine disorders, is common among women worldwide. Food insecurity (FI) and unhealthy dietary patterns can negatively affect reproductive health. The effects of the lifestyle modifications, especially dietary components, on PCOS are contradictory. The aim was the assessment of association between PCOS with food security status and dietary patterns among overweight or obese women. Methods This case-control study was performed on 240 overweight and obese women with and without PCOS (ratio 1:1) referred to the infertility clinic of Arash Hospital, Tehran, Iran. The general and socioeconomic characteristics, anthropometrics (weight, height, body mass index (BMI), waist circumference, hip circumference), physical activity, food security status, and dietary intakes (or patterns) were assessed using valid questionnaires, scales, stadiometer, and tape meter. The significant p-value was < 0.05. Results The prevalence of FI was 60% in women with PCOS and 30% in healthy women. PCOS risk was positively related to FI, quasi-western dietary patterns, low economic levels, waist circumference, and menstrual age and negatively with physical activity and healthy dietary patterns, even after controlling the potential confounders (P < 0.05). PCOS women had a higher intake of saturated fats, monounsaturated fats, oleic acid, fluorine, sucrose, and caffeine and a lower intake of vitamins A, B-5, B-6, B-12, C, and D, potassium, proteins, carbohydrates, cholesterols, docosahexaenoic acid, potassium, carotenes, lutein, beta-cryptoxanthin, lycopene, calcium, iron, thiamine, riboflavin, niacin, tetra- and dihydrofolate, biotin, phosphorus, magnesium, zinc, copper, fiber (total, insoluble, and crude), glucose, galactose, fructose, and lactose compared to the healthy women (P < 0.05). Conclusions FI, quasi-western dietary patterns, low economic levels, and waist circumference were significantly associated with the higher risk of PCOS. The lifestyle changes, especially dietary patterns, may be an essential strategy for reducing PCOS. Further studies are warranted to confirm these findings and to identify the underlying mechanisms.
C1 [Badri-Fariman, Mahtab; Mirzaei, Khadijeh] Univ Tehran Med Sci, Dept Community Nutr, Sch Nutr Sci & Dietet, Tehran, Iran.
   [Naeini, Amirmansour Alavi] Isfahan Univ Med Sci, Sch Nutr & Food Sci, Dept Community Nutr, Esfahan, Iran.
   [Moeini, Ashraf] Univ Tehran Med Sci, Sch Med, Dept Obstet & Gynecol, Tehran, Iran.
   [Hosseini, Mostafa] Univ Tehran Med Sci, Sch Publ Hlth, Dept Biostat & Epidemiol, Tehran, Iran.
   [Bagheri, Seyedeh Elaheh] Guilan Univ Med Sci, Sch Paramed, Langroud, Iran.
   [Daneshi-Maskooni, Milad] Jiroft Univ Med Sci, Sch Med, Dept Nutr, Kerman, Iran.
C3 Tehran University of Medical Sciences; Isfahan University of Medical
   Sciences; Tehran University of Medical Sciences; Tehran University of
   Medical Sciences
RP Naeini, AA (corresponding author), Isfahan Univ Med Sci, Sch Nutr & Food Sci, Dept Community Nutr, Esfahan, Iran.; Daneshi-Maskooni, M (corresponding author), Jiroft Univ Med Sci, Sch Med, Dept Nutr, Kerman, Iran.
EM am.alavi@nutr.mui.ac.ir; miladdaneshi@gmail.com
RI Bagheri, Seyedeh/AAL-1707-2021; Mirzaei, Khadijeh/D-5408-2018;
   Daneshi-Maskooni, Milad/AAC-6834-2021; Daneshi-Maskooni,
   Milad/C-1139-2019
OI Bagheri, Seyedeh Elaheh/0000-0003-4338-4262; Daneshi-Maskooni,
   Milad/0000-0003-1373-1358
FU Tehran University of Medical Sciences
FX This study was supported by the Tehran University of Medical Sciences.
   The valuable cooperation of the participants and staffs of the
   infertility clinic of Arash Hospital is acknowledged.
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NR 110
TC 13
Z9 15
U1 1
U2 16
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1757-2215
J9 J OVARIAN RES
JI J. Ovarian Res.
PD OCT 13
PY 2021
VL 14
IS 1
AR 134
DI 10.1186/s13048-021-00890-1
PG 14
WC Reproductive Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Reproductive Biology
GA WG5CP
UT WOS:000707012900004
PM 34645502
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Lou, YM
   Qin, P
   Wang, CY
   Ma, JP
   Peng, XL
   Xu, S
   Chen, HG
   Zhao, D
   Wang, L
   Liu, DC
   Li, Y
   Zhao, P
   Han, DZ
   Hu, DS
   Hu, FL
AF Lou, Yanmei
   Qin, Pei
   Wang, Changyi
   Ma, Jianping
   Peng, Xiaolin
   Xu, Shan
   Chen, Hongen
   Zhao, Dan
   Wang, Li
   Liu, Dechen
   Li, Yang
   Zhao, Ping
   Han, Dezhu
   Hu, Dongsheng
   Hu, Fulan
TI Sex-Specific Association of Serum Uric Acid Level and Change in
   Hyperuricemia Status with Risk of Type 2 Diabetes Mellitus: A Large
   Cohort Study in China
SO JOURNAL OF DIABETES RESEARCH
LA English
DT Article
ID METABOLIC SYNDROME; INSULIN-RESISTANCE; OXIDATIVE STRESS; HYPERTENSION;
   POPULATION; INHIBITION; GLUCOSE; KINASE; ADULTS; WOMEN
AB Background. Conflicting findings have been reported regarding the sex-specific association between serum uric acid (SUA) level and type 2 diabetes mellitus (T2DM) risk, and no study has explored the association between the change in hyperuricemia status and T2DM risk. The study was aimed at exploring the sex-specific association of baseline SUA and changes in hyperuricemia status with T2DM risk. Methods. We included 37,296 eligible adults without T2DM at the first examination who attended the baseline examination and at least one follow-up annual examination. Cox and logistic regression models were used to calculate hazard ratios (HRs) and odds ratios (ORs) with their 95% confidence intervals (CIs) for T2DM risk associated with baseline SUA and the change in hyperuricemia status, respectively. Results. During a median follow-up of 3.09 years, of 37,296 eligible adults, 2,263 developed T2DM. Compared with the first SUA quartile, higher quartiles were associated with an increased risk of T2DM in women (HR 1.78, 95% CI 1.17-2.71 for Q3 and 1.93, 1.27-2.93 for Q4; P-trend<0.001) but not in men. Compared with women with a persistent normal SUA level at baseline and the last follow-up, T2DM risk increased significantly among those whose SUA status changed from normal at baseline to hyperuricemia at the last follow-up (OR 1.71, 95% CI 1.12-2.55) and those with persistent hyperuricemia at baseline and the last follow-up (OR 2.37, 95% CI 1.60-3.46). However, for men, a nonsignificant association was found between the change in hyperuricemia status and T2DM risk. Conclusions. Baseline SUA and the change in hyperuricemia status were associated with T2DM risk only among women. The findings suggest the importance of monitoring SUA levels and maintaining them within a normal range for preventing or reducing incident T2DM in Chinese women.
C1 [Lou, Yanmei; Zhao, Ping] Beijing Xiaotangshan Hosp, Dept Hlth Management, Beijing, Peoples R China.
   [Qin, Pei; Li, Yang; Hu, Dongsheng; Hu, Fulan] Shenzhen Univ, Sch Publ Hlth, Dept Epidemiol & Hlth Stat, Hlth Sci Ctr, Shenzhen, Guangdong, Peoples R China.
   [Wang, Changyi; Ma, Jianping; Peng, Xiaolin; Xu, Shan; Chen, Hongen; Zhao, Dan; Wang, Li] Shenzhen Nanshan Ctr Chron Dis, Dept Noncommunicable Dis Prevent & Control, Shenzhen, Guangdong, Peoples R China.
   [Liu, Dechen; Hu, Dongsheng] Zhengzhou Univ, Sch Publ Hlth, Dept Epidemiol & Hlth Stat, Zhengzhou, Henan, Peoples R China.
   [Han, Dezhu] Beijing Fangshan Dist Yanshan Commiss Culture Hlt, Beijing, Peoples R China.
C3 Shenzhen University; Zhengzhou University
RP Hu, FL (corresponding author), Shenzhen Univ, Sch Publ Hlth, Dept Epidemiol & Hlth Stat, Hlth Sci Ctr, Shenzhen, Guangdong, Peoples R China.
EM hufu1525@163.com
RI Ma, Jianpeng/GXV-6535-2022
OI Lou, Yan-mei/0000-0002-5107-5331; Qin, Pei/0000-0003-2303-0379
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NR 39
TC 24
Z9 26
U1 0
U2 4
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2314-6745
EI 2314-6753
J9 J DIABETES RES
JI J. Diabetes Res.
PD JUL 24
PY 2020
VL 2020
AR 9637365
DI 10.1155/2020/9637365
PG 9
WC Endocrinology & Metabolism; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Research & Experimental Medicine
GA MY6YS
UT WOS:000558560700001
PM 32775463
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Asbaghi, O
   Sadeghian, M
   Sadeghi, O
   Rigi, S
   Tan, SC
   Shokri, A
   Mousavi, SM
AF Asbaghi, Omid
   Sadeghian, Mehdi
   Sadeghi, Omid
   Rigi, Somaye
   Tan, Shing Cheng
   Shokri, Azad
   Mousavi, Seyed Mohammad
TI Effects of saffron (Crocus sativusL.) supplementation on
   inflammatory biomarkers: A systematic review and meta-analysis
SO PHYTOTHERAPY RESEARCH
LA English
DT Review
DE Crocus sativus; cytokine; inflammation; meta-analysis; saffron
ID TYPE-2 DIABETES-MELLITUS; DOUBLE-BLIND; ANTIINFLAMMATORY PROPERTIES;
   METABOLIC SYNDROME; SAFETY EVALUATION; OXIDATIVE STRESS; L.; CELLS;
   CONSTITUENTS; ANTIOXIDANT
AB The effect of saffron supplementation on subclinical inflammation remains inconclusive. We performed a systematic review and meta-analysis to summarize available findings on the effect of saffron supplementation on inflammatory biomarkers (C-reactive protein [CRP], tumor necrosis factor-alpha [TNF-alpha], and interleukin-6 [IL-6]) in adults. We searched PubMed/Medline, Scopus, Web of Science, and Google Scholar databases up to November 2019 using relevant keywords to identify eligible trials. All randomized controlled trials (RCTs) that examined the effect of oral saffron supplementation on plasma concentrations of CRP, TNF-alpha, and IL-6 were included. For each outcome, mean differences andSDs were pooled using a random-effects model. Overall, eight RCTs were included in this meta-analysis. The pooled results showed that saffron supplementation did not result in significant changes in serum CRP (weighted mean difference [WMD]: -0.43 mg/L; 95% confidence interval [CI]: -1.04 to 0.17;p= .16), serum TNF-alpha (WMD: -1.29 pg/mL; 95% CI: -4.13 to 1.55;p= .37), and IL-6 concentrations (WMD: 0.11 pg/mL; 95% CI: -0.79 to 1.00;p= .81). Subgroup analysis indicated a significant reduction in serum CRP levels in studies with baseline CRP of >= 3 mg/L, saffron dosage of <= 30 mg/day, and intervention duration of <12 weeks, as well as trials that used crocin. Similarly, saffron was found to decrease TNF-alpha in studies that recruited non-diabetic subjects, subjects with baseline levels of >= 15 pg/mL, and participants with <50 years old, as well as trials that administered saffron at the dosage of <= 30 mg/day. We also found a significant non-linear effect of saffron dosage on serum CRP concentrations (p(non-linearity)= .03). The overall results indicated that saffron supplementation did not affect inflammatory cytokines. Further high-quality studies are needed to firmly establish the clinical efficacy of supplemental saffron on inflammatory biomarkers.
C1 [Asbaghi, Omid] Lorestan Univ Med Sci, Nutr Hlth Res Ctr, Khorramabad, Iran.
   [Sadeghian, Mehdi] Ahvaz Jundishapur Univ Med Sci, Student Res Comm, Ahvaz, Iran.
   [Sadeghi, Omid; Rigi, Somaye; Mousavi, Seyed Mohammad] Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Community Nutr, POB 14155-6117, Tehran, Iran.
   [Tan, Shing Cheng] Univ Kebangsaan Malaysia, UKM Med Mol Biol Inst, Kuala Lumpur, Malaysia.
   [Shokri, Azad] Gerash Univ Med Sci, Dept Nursing, Gerash, Iran.
   [Shokri, Azad] Kurdistan Univ Med Sci, Res Inst Hlth Dev, Social Determinants Hlth Res Ctr, Sanandaj, Iran.
   [Mousavi, Seyed Mohammad] Univ Tehran Med Sci, Students Sci Res Ctr, Tehran, Iran.
C3 Lorestan University of Medical Sciences; Ahvaz Jundishapur University of
   Medical Sciences (AJUMS); Tehran University of Medical Sciences;
   Universiti Kebangsaan Malaysia; Kurdistan University of Medical
   Sciences; Tehran University of Medical Sciences
RP Mousavi, SM (corresponding author), Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Community Nutr, POB 14155-6117, Tehran, Iran.
EM smmousavi@razi.tums.ac.ir
RI Mousavi, Seyed Mohammad/AAQ-7719-2020; Sadeghi, Omid/AAM-9006-2020; Tan,
   Shing Cheng/J-3435-2013
OI Shokri, Azad/0000-0003-2976-4488; Tan, Shing Cheng/0000-0002-0328-0023
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NR 77
TC 31
Z9 31
U1 0
U2 15
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0951-418X
EI 1099-1573
J9 PHYTOTHER RES
JI Phytother. Res.
PD JAN
PY 2021
VL 35
IS 1
BP 20
EP 32
DI 10.1002/ptr.6748
EA JUN 2020
PG 13
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA PZ1DN
UT WOS:000541363000001
PM 32525606
DA 2025-06-11
ER

PT J
AU Rameez, RM
   Sadana, D
   Kaur, S
   Ahmed, T
   Patel, J
   Khan, MS
   Misbah, S
   Simonson, MT
   Riaz, H
   Ahmed, HM
AF Rameez, Rabel Misbah
   Sadana, Divyajot
   Kaur, Simrat
   Ahmed, Taha
   Patel, Jay
   Khan, Muhammad Shahzeb
   Misbah, Sarah
   Simonson, Marian T.
   Riaz, Haris
   Ahmed, Haitham M.
TI Association of Maternal Lactation With Diabetes and Hypertension A
   Systematic Review and Meta-analysis
SO JAMA NETWORK OPEN
LA English
DT Review
ID CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; BLOOD-PRESSURE; DURATION;
   RISK; WOMEN; PREVALENCE; GUIDELINE; MOTHERS; STRESS
AB IMPORTANCE Lactation has been shown to be associated with lower rates of diabetes and hypertension in mothers. However, the strength of association has varied between studies, and sample sizes are relatively small.
   OBJECTIVE To conduct a systematic review and meta-analysis to determine whether lactation is associated with a lower risk of diabetes and hypertension.
   DATA SOURCES Ovid MEDLINE, Ovid Embase, Cochrane CENTRAL, and CINAHL databases were searched from inception to July 2018 with manual search of the references.
   STUDY SELECTION Studies of adult women that specified duration of breastfeeding for at least 12 months, evaluated primary hypertension and diabetes as outcomes, were full-text articles in English, and reported statistical outcomes as odds ratios were included.
   DATA EXTRACTION AND SYNTHESIS Study characteristics were independently extracted using a standard spreadsheet template and the data were pooled using the random-effects model. The Meta-analysis of Observational Studies in Epidemiology (MOOSE) guideline for reporting was followed.
   MAIN OUTCOMES AND MEASURES Diabetes and hypertension.
   RESULTS The search yielded 1558 articles, from which a total of 6 studies met inclusion criteria for association between breastfeeding and diabetes and/or hypertension. The 4 studies included in the meta-analysis for the association between lactation and diabetes had a total of 206 204 participants, and the 5 studies included in the meta-analysis for the association between lactation and hypertension had a total of 255 271 participants. Breastfeeding for more than 12 months was associated with a relative risk reduction of 30% for diabetes (pooled odds ratio, 0.70 [95% CI, 0.62-0.78]; P < .001) and a relative risk reduction of 13% for hypertension (pooled odds ratio, 0.87 [95% CI, 0.78-0.97]; P = .01).
   CONCLUSIONS AND RELEVANCE This study suggests that education about the benefits of breastfeeding for prevention of diabetes and hypertension in women is a low-risk intervention that can be easily included in daily practice and may have a positive impact on cardiovascular outcomes in mothers.
C1 [Rameez, Rabel Misbah; Kaur, Simrat; Patel, Jay] Cleveland Clin, Dept Internal Med, Cleveland, OH 44106 USA.
   [Sadana, Divyajot] Cleveland Clin, Dept Pulm & Crit Care Med, Cleveland, OH 44106 USA.
   [Ahmed, Taha] Cleveland Clin, Dept Internal Med, Fairview Hosp, Cleveland, OH 44106 USA.
   [Khan, Muhammad Shahzeb] John H Stroger Jr Hosp Cook Cty, Dept Internal Med, Chicago, IL USA.
   [Misbah, Sarah] Dow Med Coll, Karachi, Pakistan.
   [Simonson, Marian T.] Cleveland Clin, Floyd D Loop Alumni Lib, Cleveland, OH 44106 USA.
   [Riaz, Haris] Cleveland Clin, Heart & Vasc Inst, Cleveland, OH 44106 USA.
   [Ahmed, Haitham M.] AdvantageCare Phys, 101 Penn Ave, Brooklyn, NY 11207 USA.
C3 Cleveland Clinic Foundation; Cleveland Clinic Foundation; Cleveland
   Clinic Foundation; University of Illinois System; University of Illinois
   Chicago; University of Illinois Chicago Hospital; John H Stroger Junior
   Hospital Cook County; Dow University of Health Sciences; Dow Medical
   College; Cleveland Clinic Foundation; Cleveland Clinic Foundation
RP Ahmed, HM (corresponding author), AdvantageCare Phys, 101 Penn Ave, Brooklyn, NY 11207 USA.
EM ahmedh@acpny.com
RI Kaur, Simrat/KVY-4512-2024; Khan, Shahzeb/AAN-1515-2020; Patel,
   Jay/HDM-6251-2022
OI Kaur, Simrat/0000-0001-7180-6392
CR [Anonymous], The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses
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NR 49
TC 92
Z9 102
U1 1
U2 11
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 2574-3805
J9 JAMA NETW OPEN
JI JAMA Netw. Open
PD OCT
PY 2019
VL 2
IS 10
AR e1913401
DI 10.1001/jamanetworkopen.2019.13401
PG 11
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA JP0XK
UT WOS:000497997100053
PM 31617928
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Padró, T
   Cubedo, J
   Camino, S
   Béjar, MT
   Ben-Aicha, S
   Mendieta, G
   Escolà-Gil, JC
   Escate, R
   Gutiérrez, M
   Casani, L
   Badimon, L
   Vilahur, G
AF Padro, Teresa
   Cubedo, Judit
   Camino, Sandra
   Bejar, Maria Teresa
   Ben-Aicha, Soumaya
   Mendieta, Guiomar
   Carles Escola-Gil, Joan
   Escate, Rafael
   Gutierrez, Manuel
   Casani, Laura
   Badimon, Lina
   Vilahur, Gemma
TI Detrimental Effect of Hypercholesterolemia on High-Density Lipoprotein
   Particle Remodeling in Pigs
SO JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
LA English
DT Article
DE cardioprotection; cholesteryl ester; fatty acid; lipidomics; proteomics
ID CORONARY-ARTERY-DISEASE; REVERSE CHOLESTEROL TRANSPORT;
   RETINOL-BINDING-PROTEIN; APOLIPOPROTEIN-M; HEART-DISEASE;
   MYOCARDIAL-INFARCTION; HDL-CHOLESTEROL; EFFLUX CAPACITY; METABOLIC
   SYNDROME; OXIDATIVE STRESS
AB BACKGROUND Beneficial effects of high-density lipoproteins (HDL) seem altered in patients with symptomatic cardiovascular disease. We recently demonstrated in a swine model of ischemia-reperfusion (IR) that hypercholesterolemia abolishes HDL-related cardioprotection.
   OBJECTIVES This study sought to investigate, using the same animal model, whether the reported impairment of HDL cardioprotective function was associated with alterations in HDL remodeling and functionality.
   METHODS Pigs were fed a normocholesterolemic (NC) or hypercholesterolemic (HL) diet for 10 days, reaching non-HDL cholesterol concentrations of 38.2 +/- 3.5 mg/dl and 218.6 +/- 27.6 mg/dl, respectively (p < 0.0001). HDLs were isolated, and lipidomics and differential proteomics tests were performed to determine HDL molecular changes. HDL functionality and particle size were determined.
   RESULTS Using principal component analysis, we identified 255 molecular lipid species differentially clustered in NC-HDL and HL-HDL. Ninety lipid metabolites were differentially expressed, and 50 showed at least 1.5-fold variation (false discovery rate adjustment q value < 0.05). HL-HDLs presented a core enriched in cholesteryl esters and a surface depleted of phosphatidylcholine species containing polyunsaturated and long-chain fatty acids, indicating the presence of mature HDL particles with low surface fluidity. Hypercholesterolemia induced an important change in HDL-transported proteins (576 spots in HL-HDL vs. 621 spots in NC-HDL). HL-HDLs showed a reduced content of lipocalin retinol binding protein 4 and apolipoprotein M and in the retinoic acid-transporter cellular retinoic acid binding protein 1 (p < 0.05 vs. NC-HDL). No changes were observed in apolipoprotein A-I content and profile. Functionally, HL-HDL showed lower antioxidant activity (+/-35%) and a reduced capacity to efflux cholesterol (+/-60%) compared to NC-HDL (p < 0.05). Hypercholesterolemia induced larger HDL particles.
   CONCLUSIONS We demonstrate that hypercholesterolemia induces HDL lipidomic changes, losing phosphatidylcholine-lipid species and gaining cholesteryl esters, and proteomic changes, with losses in cardioprotective proteins. These remodeling changes shifted HDL particles toward a dysfunctional state. (C) 2017 by the American College of Cardiology Foundation.
C1 [Padro, Teresa; Cubedo, Judit; Camino, Sandra; Bejar, Maria Teresa; Ben-Aicha, Soumaya; Mendieta, Guiomar; Escate, Rafael; Gutierrez, Manuel; Casani, Laura; Badimon, Lina; Vilahur, Gemma] Cardiovasc Sci Inst ICCC, Barcelona, Spain.
   [Padro, Teresa; Cubedo, Judit; Camino, Sandra; Bejar, Maria Teresa; Ben-Aicha, Soumaya; Carles Escola-Gil, Joan; Escate, Rafael; Gutierrez, Manuel; Casani, Laura; Badimon, Lina; Vilahur, Gemma] IIB St Pau, Inst Invest Biomed, Barcelona, Spain.
   [Padro, Teresa; Cubedo, Judit; Badimon, Lina; Vilahur, Gemma] Inst Salud Carlos III, Ctr Invest Biomed Red Cardiovasc CIBERCV, Barcelona, Spain.
   [Mendieta, Guiomar] Hosp Clin Barcelona, Dept Cardiol, Barcelona, Spain.
   [Carles Escola-Gil, Joan] Ctr Invest Biomed Red Diabet & Enfermedades Metab, Barcelona, Spain.
   [Badimon, Lina] Univ Autonoma Barcelona, Barcelona, Spain.
C3 Instituto de Salud Carlos III; CIBER - Centro de Investigacion Biomedica
   en Red; CIBERCV; University of Barcelona; Hospital Clinic de Barcelona;
   CIBER - Centro de Investigacion Biomedica en Red; CIBERDEM; Autonomous
   University of Barcelona
RP Vilahur, G (corresponding author), Cardiovasc Sci Inst, C St Antoni Ma Claret 167, Barcelona 08025, Spain.
EM gvilahur@csic-iccc.org
RI BADIMON, LINA/S-2950-2019; Camino, Sandra/AAF-8006-2019; Casani,
   Laura/S-2115-2019; Mendieta, Guiomar/ABA-1871-2021; Escolà-Gil, Joan
   Carles/H-9522-2014; Gutierrez, Manuel/KIB-2534-2024; Ben-Aicha Gonzalez,
   Soumaya/M-8563-2018; Escate Chavez, Oscar Rafael/D-3271-2016; Badimon,
   Lina/O-4711-2014; Bejar Serrano, Maria Teresa/M-3876-2014
OI Casani, Laura/0000-0002-0139-4588; Ben-Aicha Gonzalez,
   Soumaya/0000-0001-5572-5883; Escola-Gil, Joan
   Carles/0000-0001-9021-2485; Camino Lopez, Sandra/0000-0002-2737-4892;
   Gutierrez Gimeno, Manuel/0000-0001-7362-4330; Escate Chavez, Oscar
   Rafael/0000-0002-8448-7244; Cubedo, Judit/0000-0003-3291-9137; Badimon,
   Lina/0000-0002-9162-2459; Bejar Serrano, Maria
   Teresa/0000-0002-8850-0178
FU Fundacion Investigacion Cardiovascular; Fundacion Jesus Serra
FX The authors thank the Fundacion Investigacion Cardiovascular and the
   Fundacion Jesus Serra for their continuous support and CERCA
   Programme/Generalitat de Catalunya. The authors also acknowledge M. A.
   Canovas, P. Catalina, J. Moreno, F.J. Rodriguez, and L. Fernandez for
   animal handling and care and for helping out with the molecular and in
   vitro work. The authors also thank Dr. N. Amigo for support with MRI
   technology and measurements of HDL particles.
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NR 72
TC 43
Z9 44
U1 0
U2 16
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0735-1097
EI 1558-3597
J9 J AM COLL CARDIOL
JI J. Am. Coll. Cardiol.
PD JUL 11
PY 2017
VL 70
IS 2
BP 165
EP 178
DI 10.1016/j.jacc.2017.05.018
PG 14
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA EZ2LM
UT WOS:000404540800007
PM 28683964
OA Bronze
DA 2025-06-11
ER

PT J
AU Akgun, B
   Sari, A
   Ozturk, S
   Erol, FS
   Ozercan, IH
   Ulu, R
AF Akgun, Bekir
   Sari, Aysel
   Ozturk, Sait
   Erol, Fatih Serhat
   Ozercan, Ibrahim Hanifi
   Ulu, Ramazan
TI Effects of Mucuna pruriens on Free Fatty Acid Levels and
   Histopathological Changes in the Brains of Rats Fed a High Fructose Diet
SO MEDICAL PRINCIPLES AND PRACTICE
LA English
DT Article
DE Brain; Free fatty acids; Fructose; Histopathology; Mucuna pruriens
ID METABOLIC SYNDROME
AB Objective: To investigate free fatty acid levels and histopathological changes in the brain of rats fed a high fructose diet (HFrD) and to evaluate the effects of Mucuna pruriens, known to have antidiabetic activity, on these changes. Materials and Methods: The study comprised 28 mature female Wistar rats. The rats were divided into 4 groups, each included 7 rats. Group 1: control; group 2: fed an HFrD; group 3: fed normal rat chow and M. pruriens; group 4: fed an HFrD and M. pruriens for 6 weeks. At the end of 6 weeks, the rats were decapitated, blood and brain tissues were obtained. Serum glucose and triglyceride levels were measured. Free fatty acid levels were measured in 1 cerebral hemisphere of each rat and histopathological changes in the other. The Mann-Whitney U test was used to compare quantitative continuous data between 2 independent groups, and the Kruskal-Wallis test was used to compare quantitative continuous data between more than 2 independent groups. Results: Arachidonic acid and docosahexaenoic acid levels were significantly higher in group 2 than in group 1 (p < 0.05). Free arachidonic acid and docosahexaenoic acid levels in group 4 were significantly less than in group 2 (p < 0.05). Histopathological examination of group 2 revealed extensive gliosis, neuronal hydropic degeneration, and edema. In group 4, gliosis was much lighter than in group 2, and edema was not observed. Neuronal structures in group 4 were similar to those in group 1. Conclusions: The HFrD increased the levels of free arachidonic acid and docosahexaenoic acid probably due to membrane degradation resulting from possible oxidative stress and inflammation in the brain. The HFrD also caused extensive gliosis, neuronal hydropic degeneration, and edema. Hence, M. pruriens could have therapeutic effects on free fatty acid metabolism and local inflammatory responses in the brains of rats fed an HFrD. (C) 2017 The Author(s) Published by S. Karger AG, Basel
C1 [Akgun, Bekir; Ozturk, Sait; Erol, Fatih Serhat] Firat Univ, Dept Neurosurg, Elazig, Turkey.
   [Sari, Aysel] Firat Univ, Dept Chem Biochem, Elazig, Turkey.
   [Ozercan, Ibrahim Hanifi] Firat Univ, Dept Clin Pathol, Elazig, Turkey.
   [Ulu, Ramazan] Firat Univ, Dept Internal Med, Elazig, Turkey.
C3 Firat University; Firat University; Firat University; Firat University
RP Akgun, B (corresponding author), Firat Univ Hosp, Dept Neurosurg, TR-23119 Elazig, Turkey.
EM bekirakgun@yahoo.com
RI OZERCAN, ibrahim Hanifi/W-7883-2018; ulu, ramazan/V-9751-2018; Ozturk,
   Sait/Q-1953-2016
OI Ozturk, Sait/0000-0002-7655-0127
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NR 26
TC 2
Z9 2
U1 1
U2 6
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1011-7571
EI 1423-0151
J9 MED PRIN PRACT
JI Med. Princ. Pract.
PY 2017
VL 26
IS 6
BP 561
EP 566
DI 10.1159/000481402
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA FX3ZH
UT WOS:000426011000010
PM 28898884
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Kann, PH
   Münzel, M
   Hadji, P
   Daniel, H
   Flache, S
   Nyarango, P
   Wilhelm, A
AF Kann, Peter Herbert
   Muenzel, Mark
   Hadji, Peyman
   Daniel, Hanna
   Flache, Stephan
   Nyarango, Peter
   Wilhelm, Anneke
TI Alterations of Cortisol Homeostasis May Link Changes of the
   Sociocultural Environment to an Increased Diabetes and Metabolic Risk in
   Developing Countries: A Prospective Diagnostic Study Performed in
   Cooperation With the Ovahimba People of the Kunene Region/Northwestern
SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Article
ID STRESS; WORLD; WOMEN
AB Context: Diabetes mellitus is increasingly affecting Africa.
   Objective: Urbanization of the Ovahimba people in Namibia is associated with an increased prevalence of disorders of glucose metabolism, and may thus be attributed to changes of cortisol homeostasis.
   Design: A prospective, cross-sectional, diagnostic study was applied.
   Setting: The study was conducted in the field.
   Location of the Diabetes Epidemic: Africa and Namibia.
   Participants: Ovahimba people: group 1 "urban" n = 60, 42 females, 46.3 +/- 11.3 years (town); group 2 "rural" n = 63, 44 females, 51.1 +/- 12.0 years (seminomadic).
   Interventions: oGTT, sunrise and sunset saliva cortisol, metabolic parameters, questionnaire.
   Main Outcome Measure: The prevalence of disorders of glucose metabolism (DM, IGT, IFT).
   Results: The prevalence of disorders of glucose metabolism differed significantly: urban group n = 17(28.3%) vsruralgroupn = 8(12.7%)(P = 0.04). The saliva cortisol concentrations also differed significantly: sunrise 0.34 +/- 0.18 vs 0.12 +/- 0.15 mu g/dL, sunset 0.18 +/- 0.20 vs 0.07 +/- 0.09 mu g/dL, areaunderthecurve 6.16 +/- 3.48 vs 2.28 +/- 2.56 mu g/dL (star) 24 h (all P < 0.001). Further metabolic parameters were unfavorably changed in the urban group: hip circumference (P < 0.001), waist circumference (P < 0.001), body mass index (P = 0.014), systolicBPatrest (P < 0.001), diastolic BP at rest (P = 0.002), systolic BP after exercise (P < 0.001), heart rate after exercise (P = 0.007), fastingglucose(P < 0.001), 2-h-glucose by OGTT (P = 0.002), triglycerides (P = 0.04), HDL-cholesterol (P = 0.014), prevalence of the metabolic syndrome (P < 0.001). Physical activity was higher in the rural group, and intake of fast food and sweets were higher in the urban group.
   Conclusions: Urbanization of the Ovahimba people is associated with an increasing prevalence of disorders of glucose metabolism and other unfavorable metabolic parameters. Besides changes of lifestyle, this may be attributed to an increased cortisol exposure of the Ovahimba people living in an urban environment.
C1 [Kann, Peter Herbert; Flache, Stephan; Wilhelm, Anneke] Philipps Univ Marburg, Div Endocrinol Diabetol, D-35033 Marburg, Germany.
   [Kann, Peter Herbert; Muenzel, Mark] Philipps Univ Marburg, Inst Cultural & Social Anthropol, D-35033 Marburg, Germany.
   [Hadji, Peyman] Philipps Univ Marburg, Dept Gynecol, D-35033 Marburg, Germany.
   [Daniel, Hanna] Philipps Univ Marburg, Inst Med Biometry & Epidemiol, D-35033 Marburg, Germany.
   [Flache, Stephan] Asklepios Hosp, Dept Surg, D-06667 Weissenfels, Germany.
   [Nyarango, Peter] Univ Namibia, Fac Med, Windhoek, Namibia.
C3 Philipps University Marburg; Philipps University Marburg; Philipps
   University Marburg; Philipps University Marburg; University of Namibia
RP Kann, PH (corresponding author), Philipps Univ Marburg, Div Endocrinol Diabetol, D-35033 Marburg, Germany.
EM kannp@med.uni-marburg.de
FU Novo Nordisk Pharma GmbH Germany
FX We thank Novo Nordisk Pharma GmbH Germany for generously supporting this
   study with an unrestricted grant. As with all research studies, there
   are many people providing technical support, whom we cannot all mention.
   A very special thanks to Mrs. E. Bothe and furthermore to Mr. E.J. Tolu
   and Mr. H. Philipps of Onkwele Tours in Namibia. Last but not least, and
   most importantly, our thanks go to the Ovahimba people for their
   welcoming, friendly, and fruitful cooperation. It was a real pleasure
   and honor.
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NR 18
TC 12
Z9 12
U1 0
U2 7
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0021-972X
EI 1945-7197
J9 J CLIN ENDOCR METAB
JI J. Clin. Endocrinol. Metab.
PD MAR
PY 2015
VL 100
IS 3
BP E482
EP E486
DI 10.1210/jc.2014-2625
PG 5
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA CG5TR
UT WOS:000353358900016
PM 25522263
OA Bronze
DA 2025-06-11
ER

PT J
AU Marquez, JL
   Rubinstein, S
   Fattor, JA
   Shah, O
   Hoffman, AR
   Friedlander, AL
AF Marquez, Juan L.
   Rubinstein, Scott
   Fattor, Jill A.
   Shah, Omer
   Hoffman, Andrew R.
   Friedlander, Anne L.
TI Cyclic Hypobaric Hypoxia Improves Markers of Glucose Metabolism in
   Middle-Aged Men
SO HIGH ALTITUDE MEDICINE & BIOLOGY
LA English
DT Article
DE endocrinology; glucose metabolism; hypobaric hypoxia; insulin;
   intermittent hypoxia
ID CHRONIC INTERMITTENT HYPOXIA; NORMOBARIC HYPOXIA; ENDURANCE PERFORMANCE;
   INSULIN SENSITIVITY; SUBMAXIMAL EXERCISE; OXYGEN-SATURATION; OXIDATIVE
   STRESS; SLEEP-APNEA; SEA-LEVEL; ALTITUDE
AB Marquez, Juan L., Scott Rubinstein, Jill A. Fattor, Omer Shah, Andrew R. Hoffman, and Anne L. Friedlander. Cyclic hypobaric hypoxia improves markers of glucose metabolism in middle-aged men. High Alt Med Biol 14:263272, 2013.Chronic hypoxia increases dependence on glucose in men and increases insulin sensitivity in men and women. Cyclic Variations in Altitude Conditioning (CVAC) is a novel technology that provides exposure to rapidly fluctuating cyclic hypobaric hypoxia (CHH). Purpose: To test the hypothesis that markers of glucose metabolism would change with CVAC CHH, two groups of middle-aged men were exposed to 10 weeks (40min/day, 3 day/week) of either CHH or sham (SH) sessions. Methods: CHH subjects (age: 48 +/- 6, weight: 86 +/- 12kg, BMI: 27.1 +/- 3, n=11) experienced cyclic pressures simulating altitudes ranging from sea level to 3048m (week 1) and progressing to 6096m (by week 5 through week 10). SH subjects (age: 50 +/- 4, weight: 89 +/- 15kg, BMI: 27.5 +/- 3, n=10) were exposed to slowly-fluctuating pressures up to 607m (all subjects blinded to elevation). Physical function and blood markers of glucose metabolism were measured at baseline, 3, 6, and 10 weeks. Results: Two CHH subjects were dropped from analysis for failure to progress past 3048m (CHH: n=9). Weight and physical activity remained stable for both groups. There was a group-by-time interaction in fasting glucose (CHH: 96 +/- 9 to 91 +/- 7mg/dL, SH: 94 +/- 7 to 97 +/- 9mg/dL, p<0.05). Reduction in plasma glucose response to oral glucose tolerance test [area under the curve] was greater in CHH compared to SH after 10 weeks of exposure (p<0.03). Neither group experienced changes in fasting insulin, insulin response during the OGTT, or changes in a timed walk test. Conclusion: Ten weeks of CVAC CHH exposure improves markers of glucose metabolism in middle-aged men at risk for metabolic syndrome.
C1 [Marquez, Juan L.; Rubinstein, Scott; Shah, Omer; Friedlander, Anne L.] VA Palo Alto Hlth Care Syst, Clin Studies Unit, Palo Alto, CA USA.
   [Hoffman, Andrew R.] VA Palo Alto Hlth Care Syst, Med Serv, Palo Alto, CA USA.
   [Fattor, Jill A.; Shah, Omer; Friedlander, Anne L.] Stanford Univ, Stanford Ctr Longev, Palo Alto, CA 94304 USA.
   [Friedlander, Anne L.] Stanford Univ, Program Human Biol, Palo Alto, CA 94304 USA.
C3 US Department of Veterans Affairs; Veterans Health Administration (VHA);
   VA Palo Alto Health Care System; US Department of Veterans Affairs;
   Veterans Health Administration (VHA); VA Palo Alto Health Care System;
   Stanford University; Stanford University
RP Friedlander, AL (corresponding author), Program Human Biol, 450 Serra Mall Bldg 20,Room 22J, Stanford, CA 94305 USA.
EM friedlan@stanford.edu
OI Hoffman, Andrew/0000-0002-0145-1917
FU CVAC Systems, Inc; Stanford Center on Longevity
FX We are truly grateful for the assistance of Forrest Schwartz and Amanda
   Trotter who diligently monitored many of the CVAC sessions. We would not
   have been able to complete the time intensive protocol without their
   help. This project was supported by CVAC Systems, Inc and The Stanford
   Center on Longevity.
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Z9 13
U1 1
U2 16
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1527-0297
J9 HIGH ALT MED BIOL
JI High Alt. Med. Biol.
PD SEP 1
PY 2013
VL 14
IS 3
BP 263
EP 272
DI 10.1089/ham.2012.1057
PG 10
WC Biophysics; Public, Environmental & Occupational Health; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biophysics; Public, Environmental & Occupational Health; Sport Sciences
GA 223TV
UT WOS:000324834700019
PM 24028640
DA 2025-06-11
ER

PT J
AU Udani, JK
   Singh, BB
   Singh, VJ
   Barrett, ML
AF Udani, Jay K.
   Singh, Betsy B.
   Singh, Vijay J.
   Barrett, Marilyn L.
TI Effects of Acai (Euterpe oleracea Mart.) berry preparation on
   metabolic parameters in a healthy overweight population: A pilot study
SO NUTRITION JOURNAL
LA English
DT Article
ID OXIDATIVE STRESS; ANTIOXIDANT CAPACITY; CONSUMPTION; ANTHOCYANINS;
   PREVENTION; GLUCOSE; JUICE
AB Background: The purpose of this study was to evaluate the effect of acai fruit pulp on risk factors for metabolic disorders in overweight subjects. The acai palm (Euterpe oleracea Mart.), which is native to South America, produces a small, black-purple fruit which is edible. The fruit has recently become popular as a functional food due to its antioxidant potential. Although several studies have been conducted in vitro and with animals, little is known about the potential health benefits in humans aside from an increase in plasma anti-oxidant capacity. Metabolic syndrome is a condition which is defined by a cluster of risk factors for cardiovascular disease and/or type-2 diabetes. Preliminary studies indicate that a reduction in reactive oxygen species can assist in the normalization of the metabolic pathways involved in this syndrome.
   Methods: This was an open label pilot study conducted with 10 overweight adults (BMI = 25 kg/m(2) and = 30 kg/m(2)) who took 100 g acai pulp twice daily for 1 month. The study endpoints included levels of fasting plasma glucose, insulin, cholesterol, triglycerides, exhaled (breath) nitric oxide metabolites (eNO) and plasma levels of high sensitivity C-reactive protein (hs-CRP). The response of blood glucose, blood pressure and eNO to a standardized meal was determined at baseline and following the 30 day treatment.
   Results: Compared to baseline, there were reductions in fasting glucose and insulin levels following the 30 day treatment (both p < 0.02). There was also a reduction in total cholesterol (p = 0.03), as well as borderline significant reductions in LDL-cholesterol and the ratio of total cholesterol to HDL-cholesterol (both p = 0.051). Compared to baseline, treatment with acai ameliorated the post-prandial increase in plasma glucose following the standardized meal, measured as the area under the curve (p = 0.047). There was no effect on blood pressure, hs-CRP or eNO.
   Conclusion: In this uncontrolled pilot study, consumption of acai fruit pulp reduced levels of selected markers of metabolic disease risk in overweight adults, indicating that further studies are warranted.
C1 [Udani, Jay K.; Singh, Betsy B.; Singh, Vijay J.] Medicus Res LLC, Northridge, CA 91325 USA.
   [Udani, Jay K.] Univ Calif Los Angeles, Sch Med, Dept Med, Los Angeles, CA 90024 USA.
   [Barrett, Marilyn L.] Pharmacognosy Consulting, Mill Valley, CA 94941 USA.
C3 University of California System; University of California Los Angeles;
   University of California Los Angeles Medical Center; David Geffen School
   of Medicine at UCLA
RP Udani, JK (corresponding author), Medicus Res LLC, Northridge, CA 91325 USA.
EM jay.udani@medicusresearch.com
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NR 29
TC 79
Z9 93
U1 0
U2 47
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1475-2891
J9 NUTR J
JI Nutr. J.
PD MAY 12
PY 2011
VL 10
AR 45
DI 10.1186/1475-2891-10-45
PG 7
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 780NT
UT WOS:000291865500001
PM 21569436
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Wang, YI
   Schulze, J
   Raymond, N
   Tomita, T
   Tam, K
   Simon, SI
   Passerini, AG
AF Wang, Ying I.
   Schulze, John
   Raymond, Nadine
   Tomita, Tyler
   Tam, Kayan
   Simon, Scott I.
   Passerini, Anthony G.
TI Endothelial inflammation correlates with subject triglycerides and waist
   size after a high-fat meal
SO AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
LA English
DT Article
DE atherosclerosis; dyslipidemia; triglyceride-rich lipoprotein; vascular
   cell adhesion molecule-1; tumor necrosis factor-alpha; endothelial cells
ID CELL-ADHESION MOLECULE-1; NECROSIS-FACTOR-ALPHA; RICH LIPOPROTEINS;
   HYPERTRIGLYCERIDEMIC SUBJECTS; NONFASTING TRIGLYCERIDES; POSTPRANDIAL
   STATE; METABOLIC SYNDROME; APOLIPOPROTEIN-E; GENE-EXPRESSION;
   ATHEROSCLEROSIS
AB Wang YI, Schulze J, Raymond N, Tomita T, Tam K, Simon SI, Passerini AG. Endothelial inflammation correlates with subject triglycerides and waist size after a high-fat meal. Am J Physiol Heart Circ Physiol 300: H784-H791, 2011. First published December 17, 2010; doi:10.1152/ajpheart.01036.2010.-A rise in postprandial serum triglycerides (PP-sTG) can potentiate inflammatory responses in vascular endothelial cells (ECs) and thus serves as an independent risk factor for predicting increased cardiovascular morbidity. We examined postprandial triglyceride-rich lipoproteins (PP-TGRLs) in subjects ranging from normal to hypertriglyceridemic for their capacity to alter EC acute inflammatory responses. Cultured human aortic ECs (HAECs) were conditioned with PP-TGRLs isolated from human serum at the peak after a moderately high-fat meal. VLDL particle size increased postprandially and varied directly with the subject's PP-sTG level and waist circumference. PP-TGRL particles bound to HAECs and were internalized via LDL receptor-mediated endocytosis. PP-TGRL alone did not induce an inflammatory response over the range of individuals studied. However, combined with low-dose TNF-alpha stimulation (0.3 ng/ml), it elicited a net 10-15% increase above cytokine alone in the membrane expression of VCAM-1, ICAM-1, and E-selectin, which was not observed with fasting TGRLs. In contrast to upregulation of ICAM-1 and E-selectin, VCAM-1 transcription and expression varied in direct proportion with individual PP-sTG and waist circumference. The extent of monocyte arrest on inflamed HAECs under shear stress also correlated closely with VCAM-1 expression induced by conditioning with PP-TGRL and TNF-alpha stimulation. This ex vivo approach provides a quantitative means to assess an individual's inflammatory potential, revealing a greater propensity for endothelial inflammation in hypertriglyceridemic individuals with abdominal obesity.
C1 [Wang, Ying I.; Schulze, John; Raymond, Nadine; Tomita, Tyler; Tam, Kayan; Simon, Scott I.; Passerini, Anthony G.] Univ Calif Davis, Dept Biomed Engn, Davis, CA 95616 USA.
C3 University of California System; University of California Davis
RP Passerini, AG (corresponding author), Univ Calif Davis, Dept Biomed Engn, 451 E Hlth Sci Dr, Davis, CA 95616 USA.
EM agpasserini@ucdavis.edu
RI Wang, Ying/AAW-4053-2021
OI Wang, Ying/0000-0003-0236-5962; Tam, Kayan/0000-0003-0534-1691;
   Passerini, Anthony/0000-0001-8007-4672
FU National Heart, Lung, and Blood Institute [R01-HL-082689]; Howard Hughes
   Medical Institute
FX This work was supported by National Heart, Lung, and Blood Institute
   Grant R01-HL-082689 (to S. I. Simon and A. G. Passerini) and a Howard
   Hughes Medical Institute Med Into Grad Fellowship (University of
   California-Davis; to Y. I. Wang).
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NR 37
TC 45
Z9 57
U1 0
U2 12
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0363-6135
EI 1522-1539
J9 AM J PHYSIOL-HEART C
JI Am. J. Physiol.-Heart Circul. Physiol.
PD MAR
PY 2011
VL 300
IS 3
BP H784
EP H791
DI 10.1152/ajpheart.01036.2010
PG 8
WC Cardiac & Cardiovascular Systems; Physiology; Peripheral Vascular
   Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Physiology
GA 728ZV
UT WOS:000287914900011
PM 21169396
OA Green Published
DA 2025-06-11
ER

PT J
AU Stojic, S
   Eriks-Hoogland, I
   Gamba, M
   Valido, E
   Minder, B
   Chatelan, A
   Karagounis, LG
   Ballesteros, M
   Díaz, C
   Brach, M
   Stoyanov, J
   Diviani, N
   Rubinelli, S
   Perret, C
   Glisic, M
AF Stojic, S.
   Eriks-Hoogland, I.
   Gamba, M.
   Valido, E.
   Minder, B.
   Chatelan, A.
   Karagounis, L. G.
   Ballesteros, M.
   Diaz, C.
   Brach, M.
   Stoyanov, J.
   Diviani, N.
   Rubinelli, S.
   Perret, C.
   Glisic, Marija
TI Mapping of Dietary Interventions Beneficial in the Prevention of
   Secondary Health Conditions in Spinal Cord Injured Population: A
   Systematic Review
SO JOURNAL OF NUTRITION HEALTH & AGING
LA English
DT Review
DE Spinal cord injury; nutrition; cardiovascular diseases; gastrointestinal
   health; functioning; neurological recovery
ID N-3 FATTY-ACIDS; URINARY-TRACT-INFECTIONS; DISEASE RISK-FACTORS;
   SERUM-LIPID PROFILE; CARDIOVASCULAR-DISEASE; GUT MICROBIOTA; CREATINE
   SUPPLEMENTATION; METABOLIC SYNDROME; BLOOD-PRESSURE; DOUBLE-BLIND
AB ObjectivesIndividuals with spinal cord injury are at risk of secondary health conditions (SHC) that develop as a consequence of autonomic dysfunction, prolonged oxidative stress and inflammation, and physical inactivity coupled with inadequate energy and nutritional intake. SHC can be debilitating and even life-threatening, and its prevention remains one of the major challenges in the continuum of medical care of aging SCI population. An unhealthy diet is a major driver of inflammation, oxidative stress, and unfavourable metabolic status and may be a practical preventive target to tackle increased SHC risk post-injury.AimsTo provide a catalogue of dietary interventions beneficial in prevention of SHC among individuals with SCI by conducting a systematic review of the literature on dietary interventions and dietary supplementation in promoting health and well-being after the injury. In addition, we aimed to provide a summary of observational studies exploring the association between habitual diet (macro- and micronutrients intake and dietary patterns) and health patterns following the injury.MethodThis review was registered at PROSPERO (University of York) with registration number CRD42022373773. Four medical databases (EMBASE.com, MEDLINE [Ovid], Cochrane CENTRAL, and Web of Science Core Collection) and Google Scholar were searched from inception until 11th July 2022. Studies were included if they were clinical trials or observational studies conducted in adult individuals with SCI and provided information of interest. Based on strength of the study design and risk of bias assessment (using the NIH tool), we classified studies from Level 1 (most reliable studies) to Level 4 (least reliable studies).ResultsOf 12,313 unique citations, 47 articles (based on 43 original studies) comprising 32 interventional (22 RCTs, 3 NRCT, and 7 pre-post studies) and 11 observational studies (2 cohort studies, 2 case-control, 1 post-intervention follow-up study, and 6 cross-sectional studies) were included in the present systematic review. Twenty studies (46.5%) were classified as Level 1 or 2, indicating high/moderate methodological quality. Based on those studies, dietary strategies including high protein diet, intermittent fasting, balanced diet in combination with physical conditioning and electrical stimulation, and dietary supplementation including alpha-lipoic acid, creatine, vitamin D, and cranberry-derived supplements and probiotics were mapped as the most promising in prevention of SHC among individuals with SCI.ConclusionsTo develop timely and effective preventive strategies targeting major SHC (e.g., cardiometabolic diseases, urinary tract infections) in SCI, further research is warranted to confirm the effectiveness of dietary strategies/interventions identified through the current systematic review of the literature.
C1 [Stojic, S.; Eriks-Hoogland, I.; Valido, E.; Brach, M.; Stoyanov, J.; Diviani, N.; Rubinelli, S.; Perret, C.; Glisic, Marija] Swiss Parapleg Res, Nottwil, Switzerland.
   [Eriks-Hoogland, I.; Valido, E.; Diviani, N.; Rubinelli, S.; Perret, C.] Univ Lucerne, Fac Hlth Sci & Med, Luzern, Switzerland.
   [Gamba, M.; Karagounis, L. G.; Ballesteros, M.; Diaz, C.; Glisic, Marija] Univ Bern, Inst Social & Prevent Med, Bern, Switzerland.
   [Gamba, M.] Univ Bern, Grad Sch Hlth Sci, Bern, Switzerland.
   [Minder, B.] Univ Bern, Univ Lib Bern, Publ Hlth & Primary Care Lib, Bern, Switzerland.
   [Chatelan, A.] HES SO Univ Appl Sci & Arts Western Switzerland, Geneva Sch Hlth Sci, Dept Nutr & Dietet, Geneva, Switzerland.
   [Karagounis, L. G.] Australian Catholic Univ ACU, Mary MacKillop Inst Hlth Res MMIHR, Melbourne, Australia.
   [Ballesteros, M.] Ctr Invest Red Epidemiol & Salud Publ CIBERESP, Madrid, Spain.
   [Glisic, Marija] Swiss Parapleg Res, Guido A Zach Str 4, CH-6207 Nottwil, Switzerland.
C3 Swiss Paraplegic Research; University of Lucerne; Swiss School of Public
   Health (SSPH+); University of Bern; University of Bern; University of
   Bern; University of Applied Sciences & Arts Western Switzerland;
   Australian Catholic University; CIBER - Centro de Investigacion
   Biomedica en Red; CIBERESP; Swiss Paraplegic Research
RP Glisic, M (corresponding author), Swiss Parapleg Res, Guido A Zach Str 4, CH-6207 Nottwil, Switzerland.
EM marija.glisic@paraplegie.ch
RI Diviani, Nicola/J-8074-2012; Valido, Ezra/HNC-2417-2023; Chatelan,
   Angeline/ABH-5265-2020
OI Valido, Ezra/0000-0002-2172-357X; Chatelan,
   Angeline/0000-0003-4326-4789; Rubinelli, Sara/0000-0003-1086-8914;
   Karagounis, Leonidas/0000-0003-2403-3387; Diviani,
   Nicola/0000-0002-1386-9915; Minder, Beatrice/0000-0003-1345-2594;
   Perret, Claudio/0000-0003-3953-589X
FU Swiss Paraplegic Foundation, Nottwil, Switzerland [Foko_2021_01];
   University of Bern
FX This work is supported by the Swiss Paraplegic Foundation, Nottwil,
   Switzerland (Project ID: Foko_2021_01). Open Access funding provided by
   University of Bern.
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NR 96
TC 3
Z9 3
U1 1
U2 3
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1279-7707
EI 1760-4788
J9 J NUTR HEALTH AGING
JI J. Nutr. Health Aging
PD JUL
PY 2023
VL 27
IS 7
BP 524
EP 541
DI 10.1007/s12603-023-1937-6
EA JUL 2023
PG 18
WC Geriatrics & Gerontology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology; Nutrition & Dietetics
GA M8DX7
UT WOS:001023408000001
PM 37498100
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Torres, A
   Rodríguez-Adanero, C
   Fernández-Rivera, C
   Marrero-Miranda, D
   de Bonis-Redondo, E
   Rodríguez-Hernández, AP
   Pérez-Tamajón, L
   González-Rinne, A
   alvarez-Sosa, D
   Alvarez-González, A
   Sanchez-Dorta, N
   Pérez-Carreño, E
   Díaz-Martín, L
   Luis-Lima, S
   Rodríguez-Rodríguez, AE
   González, AMD
   Romero-Delgado, C
   Calvo-Rodríguez, M
   Seijo-Bestilleiro, R
   Rodríguez-Jiménez, C
   López, MAP
   Rivero-González, AM
   Hernández-Marrero, D
   Porrini, E
AF Torres, Armando
   Rodriguez-Adanero, Concepcion
   Fernandez-Rivera, Constantino
   Marrero-Miranda, Domingo
   de Bonis-Redondo, Eduardo
   Rodriguez-Hernandez, Aurelio P.
   Perez-Tamajon, Lourdes
   Gonzalez-Rinne, Ana
   alvarez-Sosa, Diego
   alvarez-Gonzalez, Alejandra
   Sanchez-Dorta, Nuria
   Perez-Carreno, Estefania
   Diaz-Martin, Laura
   Luis-Lima, Sergio
   Rodriguez-Rodriguez, Ana E.
   Gonzalez, Antonia Maria de Vera
   Romero-Delgado, Cristina
   Calvo-Rodriguez, Maria
   Seijo-Bestilleiro, Rocio
   Rodriguez-Jimenez, Consuelo
   Lopez, Manuel Arturo Prieto
   Rivero-Gonzalez, Antonio Manuel
   Hernandez-Marrero, Domingo
   Porrini, Esteban
TI Efficacy of the Once-Daily Tacrolimus Formulation LCPT Compared to the
   Immediate-Release Formulation in Preventing Early Post-Transplant
   Diabetes in High-Risk Kidney Transplant Patients: A Randomized,
   Controlled, Open-Label Pilot Study (EUDRACT: 2017-000718-52)
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Article
DE kidney transplantation; post-transplant diabetes; post-transplant
   prediabetes; tacrolimus pharmacokinetics; early-release tacrolimus; LCPT
   tacrolimus
ID INSULIN; IMPACT; TRIAL
AB Background/Objectives: Post-transplant diabetes mellitus (PTDM) and prediabetes (PreDM) are common after renal transplantation and increase the risk of cardiovascular events and mortality. Compared to immediate-release tacrolimus (IR-Tac), the LCPT formulation, with delayed absorption, offers higher bioavailability and a smoother time-concentration curve, potentially reducing beta-cell stress. Methods: This randomized pilot trial compared de novo immunosuppression with IR-Tac (twice daily) and LCPT (once daily). At-risk recipients (age >= 60 years or 18-59 years with metabolic syndrome) were enrolled and followed for 3 months. The primary and secondary outcomes were the incidence of PTDM and PreDM, respectively. Results: 27 patients were randomized to IR-Tac and 25 to LCPT. The incidence of PTDM was comparable between groups [IR Tac: 18.5% (95% CI: 8.2-36.7%) vs. LCPT: 24% (95% CI: 11.5-43.4%); p = 0.7]. Although not statistically significant, the LCPT group exhibited a trend toward a reduction in PreDM incidence [IR-Tac: 40.7% (95% CI: 25-59%) vs. LCPT: 20% (95% CI: 9-39%); p = 0.1]. A sensitivity analysis showed similar results, with no significant differences in cumulative corticosteroid doses or baseline body mass index (BMI) between groups. The LCPT group showed a trend toward higher tacrolimus exposure at the end of the study [trough levels: IR-Tac group 8.3 (6.9-9.2) vs. LCPT group 9.4 (7.4-11.4) ng/mL; p = 0.05)], as well as fewer acute rejection episodes (none vs. three). Delayed graft function was more common in the IR-Tac group (37% vs. 8%; p = 0.01), and the eGFR was lower. Adverse events were comparable between groups. Conclusions: The potential biological activity of LCPT in preventing glucose metabolic alterations in at-risk patients warrants further investigation.
C1 [Torres, Armando; Rodriguez-Adanero, Concepcion; Marrero-Miranda, Domingo; de Bonis-Redondo, Eduardo; Rodriguez-Hernandez, Aurelio P.; Perez-Tamajon, Lourdes; Gonzalez-Rinne, Ana; alvarez-Sosa, Diego; alvarez-Gonzalez, Alejandra; Sanchez-Dorta, Nuria; Lopez, Manuel Arturo Prieto; Hernandez-Marrero, Domingo] Hosp Univ Canarias, Nephrol Serv, San Cristobal la Laguna 38320, Spain.
   [Torres, Armando; Rodriguez-Rodriguez, Ana E.; Hernandez-Marrero, Domingo; Porrini, Esteban] Univ La Laguna, Inst Tecnol Biomed ITB, San Cristobal la Laguna 38206, Spain.
   [Fernandez-Rivera, Constantino; Calvo-Rodriguez, Maria; Seijo-Bestilleiro, Rocio] Complejo Hosp Univ Coruna, Serv Nefrol, La Coruna 15006, Spain.
   [Perez-Carreno, Estefania; Diaz-Martin, Laura] Hosp Univ Canarias, Res Unit, San Cristobal la Laguna 38320, Spain.
   [Luis-Lima, Sergio; Gonzalez, Antonia Maria de Vera] Hosp Univ Canarias, Cent Lab, San Cristobal la Laguna 38320, Spain.
   [Romero-Delgado, Cristina] Hosp Univ Canarias, Pharm Serv, San Cristobal la Laguna 38320, Spain.
   [Rodriguez-Jimenez, Consuelo] Hosp Univ Canarias, Pharmacol Serv, San Cristobal la Laguna 38320, Spain.
   [Rivero-Gonzalez, Antonio Manuel] Hosp Univ Nuestra Senora Candelaria, Nephrol Serv, Tenerife 38010, Spain.
C3 Universidad de la Laguna; University Hospital of the Canary Islands;
   Universidad de la Laguna; Complejo Hospitalario Universitario A Coruna;
   Universidad de la Laguna; University Hospital of the Canary Islands;
   Universidad de la Laguna; University Hospital of the Canary Islands;
   Universidad de la Laguna; University Hospital of the Canary Islands;
   Universidad de la Laguna; University Hospital of the Canary Islands
RP Torres, A (corresponding author), Hosp Univ Canarias, Nephrol Serv, San Cristobal la Laguna 38320, Spain.; Torres, A (corresponding author), Univ La Laguna, Inst Tecnol Biomed ITB, San Cristobal la Laguna 38206, Spain.
EM atorresram@gmail.com; c.rguez.adanero@gmail.com;
   constantino.fernandez.rivera@sergas.es; dmarrero72@hotmail.com;
   ebonis@telefonica.net; aureliopas@hotmail.com; mpertam28@gmail.com;
   rinneanag@yahoo.es; diegoalvarezsosa@yahoo.es; alejandramag73@gmail.com;
   nuriasanchezdorta@gmail.com; estefaniaperezc@gmail.com;
   lauradiazmart@gmail.com; luis.lima.sergio@gmail.com;
   anarrguez@gmail.com; adeverag@gmail.com;
   cromdels@gobiernodecanarias.org; maria.calvo.rodriguez@sergas.es;
   rocio.seijo.bestilleiro@sergas.es; conrodjim@gmail.com;
   manuloprieto1999@gmail.com; arivero61@hotmail.com;
   domingohernandez@gmail.com; estebanporrini72@hotmail.com
RI Luis-Lima, Sergio/F-7241-2018; Hernandez, Domingo/R-4041-2019
FU Nephrology Department at Hospital Universitario de Canarias (Fundacion
   Bioavance) [FBIO 2024.001]
FX This study was supported by research funding from the Nephrology
   Department at Hospital Universitario de Canarias (Fundacion Bioavance,
   FBIO 2024.001).
CR American Diabetes Association, 2018, Diabetes Care, V41, pS13, DOI 10.2337/dc18-S002
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NR 21
TC 0
Z9 0
U1 1
U2 1
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD DEC
PY 2024
VL 13
IS 24
AR 7802
DI 10.3390/jcm13247802
PG 13
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA Q8F5U
UT WOS:001386968800001
PM 39768725
OA gold
DA 2025-06-11
ER

PT J
AU Zhang, ZR
   Xiao, Y
   Long, PP
   Yu, YQ
   Liu, YY
   Liu, K
   Yang, HD
   Li, XL
   He, MA
   Wu, TC
   Yuan, Y
AF Zhang, Zirui
   Xiao, Yang
   Long, Pinpin
   Yu, Yanqiu
   Liu, Yiyi
   Liu, Kang
   Yang, Handong
   Li, Xiulou
   He, Meian
   Wu, Tangchun
   Yuan, Yu
TI Associations between plasma metal/metalloid mixtures and the risk of
   central obesity: A prospective cohort study of Chinese adults
SO ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
LA English
DT Article
DE Plasma multiple metals; Central obesity; Joint association; Prospective
   study
ID METABOLIC SYNDROME; BODY-FAT; MITOCHONDRIAL DYSFUNCTION;
   CARDIOVASCULAR-DISEASE; MANGANESE DEFICIENCY; THALLIUM EXPOSURE;
   OXIDATIVE STRESS; ADIPOSE-TISSUE; SERUM ZINC; WEIGHT
AB Central obesity has increased rapidly over the past decade and posed a substantial disease burden worldwide. Exposure to metals/metalloids has been acknowledged to be involved in the development of central obesity through regulation of cortisol, insulin resistance, and glucocorticoid receptor reduction. Despite the importance, it is lack of prospective study which comprehensively evaluate the relations between multiple metals exposure and central obesity. We explored the prospective associations of plasma metal concentrations with central obesity in a prospective study of the Dongfeng-Tongji cohort. The present study included 2127 participants with a 6.87-year mean follow-up duration. We measured 23 plasma metal/metalloid concentrations at baseline. The associations between metals and incident central obesity were examined utilizing the Cox proportional hazard regression in single and multiple metals models. Additionally, we applied elastic net (ENET), Bayesian kernel machine regression (BKMR), plasma metal score (PMS), and quantile-based g-computation (Qgcomp) models to explore the joint associations of metal mixtures with central obesity. After adjusting potential confounders, we found significant associations of plasma manganese (Mn) and thallium (Tl) concentrations with a higher risk of central obesity, whereas plasma rubidium (Rb) concentration was associated with a lower risk of central obesity both in single and multiple metals models (all FDR <0.05). The ENET and Qqcomp models verified similar metals (Mn, Rb, and Tl) as important predictors for central obesity. The results of both BKMR model and PMS suggested cumulative exposure to metal mixtures was associated with a higher risk of central obesity. Our findings suggested that co-exposure to metals was associated with a higher risk of central obesity. This study expands our knowledge that the management of metals/metalloids exposure may be beneficial for the prevention of newonset central obesity, which may subsequently alleviate the disease burden of late-life health outcomes.
C1 [Zhang, Zirui; Xiao, Yang; Long, Pinpin; Yu, Yanqiu; Liu, Yiyi; Liu, Kang; He, Meian; Wu, Tangchun; Yuan, Yu] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Dept Occupat & Environm Hlth, Wuhan, Peoples R China.
   [Yang, Handong; Li, Xiulou] Hubei Univ Med, Dongfeng Cent Hosp, Dept Cardiovasc Dis, Shiyan, Peoples R China.
C3 Huazhong University of Science & Technology; Hubei University of
   Medicine
RP Yuan, Y (corresponding author), Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Dept Occupat & Environm Hlth, Wuhan, Peoples R China.
EM yuyuan8hust@163.com
RI yang, xiao/HJI-7815-2023; LONG, PP/LCQ-5408-2024; yu, ye/KVB-7532-2024
FU Key Laboratory of Environment and Health, Tongji Medical College;
   National Natural Science Foundation of China [81930092, 82021005,
   82192903, 82003428]; Fundamental Research Funds for the Central Univer-
   sities [2019kfyXMBZ015, 2021XXJS019]; Foundation of the Na- tional Key
   Research and Development Program of China [2016YFC0900800]; China
   Postdoctoral Science Foundation [2022M721242]
FX The present study would not have been possible without the participation
   of the study. We would like to thank the support of Key Laboratory of
   Environment and Health, Tongji Medical College. The authors gratefully
   acknowledge financial support from the National Natural Science
   Foundation of China (81930092, 82021005, 82192903, 82003428) , the
   Fundamental Research Funds for the Central Univer- sities
   (2019kfyXMBZ015, 2021XXJS019) , the Foundation of the Na- tional Key
   Research and Development Program of China (2016YFC0900800) , China
   Postdoctoral Science Foundation (2022M721242) .
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NR 105
TC 1
Z9 1
U1 3
U2 27
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0147-6513
EI 1090-2414
J9 ECOTOX ENVIRON SAFE
JI Ecotox. Environ. Safe.
PD JAN 15
PY 2024
VL 270
AR 115838
DI 10.1016/j.ecoenv.2023.115838
EA DEC 2023
PG 12
WC Environmental Sciences; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Toxicology
GA FQ4G1
UT WOS:001147295600001
PM 38128312
OA gold
DA 2025-06-11
ER

PT J
AU Yazdanpanah, Z
   Salehi-Abargouei, A
   Mozaffari, Z
   Hemayati, R
AF Yazdanpanah, Zeinab
   Salehi-Abargouei, Amin
   Mozaffari, Zohre
   Hemayati, Roya
TI The effect of green tea (Camellia sinensis) on lipid profiles and
   renal function in people with type 2 diabetes and nephropathy: a
   randomized controlled clinical trial
SO FRONTIERS IN NUTRITION
LA English
DT Article
DE diabetic nephropathy; green tea; lipid profiles; glycated hemoglobin
   A1c; kidney function
ID METABOLIC SYNDROME; OXIDATIVE STRESS; BLOOD-PRESSURE; EXTRACT; OBESE;
   SUPPLEMENTATION; POLYPHENOLS; CATECHIN; INDIVIDUALS; CHOLESTEROL
AB Introduction Diabetic nephropathy is one of the most important microvascular complications of diabetes. Despite the modern treatments, herbs or medicinal plants have gained wide attention. One of these herbs is green tea (Camellia sinensis), which may have an impact on renal function, lipid profiles, and HbA1c. However, the evidence for this is unclear and limited. The present study aimed to evaluate the effect of different doses of green tea on these parameters in type 2 diabetes patients (T2DM) with nephropathy.Methods Sixty-six individuals with T2DM nephropathy (aged 30-70 years) were randomly assigned to receive three cups of green tea/day (n = 22), two cups of green tea/day (n = 22), and the control group (n = 22) for 12 weeks. Lipid profiles, glycated hemoglobin A1c (HbA1c), and renal markers were measured before and after intervention. Data were analyzed using SPSS software version 23. One-way analysis of variance (ANOVA), least significant difference (LSD) post hoc, and analysis of covariance were used to compare quantitative variables.Results In total, 64 participants completed the study. Consuming three cups of infusion green tea per day (7.5 gr) led to a significant reduction in serum levels of total cholesterol (p = 0.009) and HbA1c (p = 0.006) and increased in high-density lipoprotein cholesterol (HDL-C) (p = 0.02) compared with the control group who did not drink green tea. However, no significant differences were observed for other variables.Conclusion In general, it was found that drinking three cups of green tea infusion (7.5 gr) per day produced beneficial effects on some lipid profiles and HbA1c without any adverse effects on renal function in patients with T2DM nephropathy. More studies are needed to fully elucidate these findings.Clinical trial registration Iranian Registry of Clinical Trials (www.irct.ir) under registry number: IRCT2014020114538N2.
C1 [Yazdanpanah, Zeinab; Salehi-Abargouei, Amin] Shahid Sadoughi Univ Med Sci, Res Ctr Food Hyg & Safety, Sch Publ Hlth, Yazd, Iran.
   [Yazdanpanah, Zeinab; Salehi-Abargouei, Amin] Shahid Sadoughi Univ Med Sci, Sch Publ Hlth, Dept Nutr, Yazd, Iran.
   [Salehi-Abargouei, Amin] Shahid Sadoughi Univ Med Sci, Noncommunicable Dis Res Inst, Yazd Cardiovasc Res Ctr, Yazd, Iran.
   [Mozaffari, Zohre; Hemayati, Roya] Shahid Sadoughi Univ Med Sci, Dept Internal Med, Yazd, Iran.
   [Hemayati, Roya] Shahid Sadoughi Univ Med Sci, Diabet Res Ctr, Yazd, Iran.
C3 Shahid Sadoughi University of Medical Sciences; Shahid Sadoughi
   University of Medical Sciences; Shahid Sadoughi University of Medical
   Sciences; Shahid Sadoughi University of Medical Sciences; Shahid
   Sadoughi University of Medical Sciences
RP Hemayati, R (corresponding author), Shahid Sadoughi Univ Med Sci, Dept Internal Med, Yazd, Iran.; Hemayati, R (corresponding author), Shahid Sadoughi Univ Med Sci, Diabet Res Ctr, Yazd, Iran.
EM drhemayati@ssu.ac.ir
RI Salehi-Abargouei, Amin/C-9039-2011; hemayati, roya/AAD-7765-2020
FU Diabetes Research Center and Clinics, Shahid Sadoughi University of
   Medical Sciences, Yazd, Iran
FX We appreciate all the participants for their interest and enthusiastic
   involvement in this study. This article is the result of a research
   project approved and funded at the Diabetes Research Center and Clinics,
   Shahid Sadoughi University of Medical Sciences, Yazd, Iran. We also
   grateful to the staff of this center for their executive assistance.r
   This manuscript was supported by the Diabetes Research Center and
   Clinics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
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NR 48
TC 3
Z9 3
U1 4
U2 11
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD DEC 14
PY 2023
VL 10
AR 1253275
DI 10.3389/fnut.2023.1253275
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA DP0N1
UT WOS:001133142100001
PM 38162524
OA gold
DA 2025-06-11
ER

PT J
AU Kong, M
   Zhong, CR
   Gao, Q
   Zhou, XZ
   Chen, RJ
   Xiong, GP
   Hao, LP
   Yang, XF
   Lu, ZX
   Yang, NH
AF Kong, Man
   Zhong, Chunrong
   Gao, Qin
   Zhou, Xuezhen
   Chen, Renjuan
   Xiong, Guoping
   Hao, Liping
   Yang, Xuefeng
   Lu, Zhongxin
   Yang, Nianhong
TI Association of elevated mid-pregnancy maternal plasma ferritin
   concentrations and triglyceride concentrations with the risk of
   gestational diabetes mellitus: A prospective cohort study
SO DIABETES-METABOLISM RESEARCH AND REVIEWS
LA English
DT Article
DE ferritin; gestational diabetes mellitus; mediation; triglyceride
ID SERUM FERRITIN; IRON OVERLOAD; METABOLIC SYNDROME; WOMEN; STRESS; ONSET
AB Objective: Ferritin levels are well known to be associated with gestational diabetes mellitus (GDM). However, the association of the combination of ferritin and triglyceride (TG) levels in early mid-pregnancy with GDM has not been studied in depth. We investigated the independent and combined relationships of plasma ferritin and TG concentrations with the risk of GDM as well as the mediation effect of TG on ferritin.
   Methods: We analysed 2071 pregnant women from the Tongji Maternal and Child Health Cohort who had their plasma ferritin and TG concentrations measured at 11-20 weeks of gestation. Associations between ferritin and TG concentrations and GDM risk were estimated using multivariable logistic regression models. Youden's index was calculated to find the cut-off values of ferritin and TG by ROC curve analysis. The mediation effect of the TG concentration on the ferritin level with GDM risk was explored by a mediation analysis.
   Results: A total of 264 (12.3%) participants developed GDM. The median and IQR of ferritin was 53.9 (30.5-92.7) ng/mL. After adjusting for potential confounders, the relative risks (RRs) and 95% confidence intervals of GDM were 2.19 (1.42, 3.39) for ferritin and 2.02 (1.37, 2.97) for TG. The adjusted RR for combination was 2.40 (1.62, 3.55). Moreover, we found that the TG concentration mediated 15.0% of the total effect of the ferritin concentration on the risk of GDM.
   Conclusions: Women with a combination of both high plasma ferritin (.55.7 ng/mL) and high TG (.1.9 mmoL/L) were at the highest risk of GDM. Additionally, we have revealed for the first time that an elevated maternal TG concentration in early pregnancy mediates the relationship between ferritin concentration and GDM risk. Trial registration: This trial is registered at https://ClinicalTrials.gov as NCT03099837.
C1 [Kong, Man; Lu, Zhongxin] Huazhong Univ Sci & Technol, Cent Hosp Wuhan, Tongji Med Coll, Dept Med Lab, Wuhan, Hubei, Peoples R China.
   [Zhong, Chunrong; Gao, Qin; Zhou, Xuezhen; Chen, Renjuan; Hao, Liping; Yang, Xuefeng; Yang, Nianhong] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Dept Nutr & Food Hyg,Hubei Key Lab Food Nutr & Saf, Wuhan, Hubei, Peoples R China.
   [Xiong, Guoping] Huazhong Univ Sci & Technol, Cent Hosp Wuhan, Tongji Med Coll, Dept Obstet, Wuhan, Hubei, Peoples R China.
C3 Huazhong University of Science & Technology; Huazhong University of
   Science & Technology; Huazhong University of Science & Technology
RP Lu, ZX (corresponding author), Huazhong Univ Sci & Technol, Cent Hosp Wuhan, Tongji Med Coll, Dept Med Lab, Wuhan, Hubei, Peoples R China.; Yang, NH (corresponding author), Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Dept Nutr & Food Hyg,Hubei Key Lab Food Nutr & Saf, Wuhan, Hubei, Peoples R China.
EM luzhongxin@zxhospital.com; zynh@mails.tjmu.edu.cn
RI Xiong, Guoping/H-9553-2014; Yang, Xuefeng/AAB-7163-2019; Yang,
   Nianhong/IQS-4379-2023
FU National Program on Basic Research Project of China [2013FY114200];
   Wuhan Central Hospital Discipline Fund [2021xk75]
FX ACKNOWLEDGEMENTS We thank all the participants involved in this study
   and the clinics for their indispensable contribution. Funding was
   received from the National Program on Basic Research Project of China
   (2013FY114200 for Nianhong Yang) and the Wuhan Central Hospital
   Discipline Fund (2021xk75 for Man Kong).
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NR 41
TC 3
Z9 5
U1 3
U2 16
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1520-7552
EI 1520-7560
J9 DIABETES-METAB RES
JI Diabetes-Metab. Res. Rev.
PD SEP
PY 2023
VL 39
IS 6
AR e3637
DI 10.1002/dmrr.3637
EA APR 2023
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA R0WO2
UT WOS:000969162900001
PM 36958940
DA 2025-06-11
ER

PT J
AU Zamani, M
   Zarei, M
   Nikbaf-Shandiz, M
   Hosseini, S
   Shiraseb, F
   Asbaghi, O
AF Zamani, Mohammad
   Zarei, Mahtab
   Nikbaf-Shandiz, Mahlagha
   Hosseini, Shabnam
   Shiraseb, Farideh
   Asbaghi, Omid
TI The effects of berberine supplementation on cardiovascular risk factors
   in adults: A systematic review and dose-response meta-analysis
SO FRONTIERS IN NUTRITION
LA English
DT Review
DE berberine; cardiovascular risk factors; systematic review;
   meta-analysis; adult
ID TYPE-2 DIABETES-MELLITUS; FATTY LIVER-DISEASE; C-REACTIVE PROTEIN;
   LINOLEIC-ACID CLA; METABOLIC SYNDROME; OXIDATIVE STRESS; GLYCEMIC
   CONTROL; DOUBLE-BLIND; AMP KINASE; SAFETY
AB Cardiovascular disease (CVD) is a major concern today. Herbal medicine is one helping way to control CVD risks. One conclusive of herbal medicine is Berberine (BBR) and converse about it still exists, to clarify this issue, this meta-analysis was performed. PubMed/Medline, Scopus, and Web of Science were searched for RCTs in adults on the effect of BBR supplementation on CVD risk factors up to July 2022. The pooled results showed BBR significantly reduced triglyceride (WMD = -23.70 mg/dl; 95%CI -30.16, -17.25; P < 0.001), total cholesterol (WMD = -20.64 mg/dl; 95%CI -23.65, -17.63; P < 0.001), low-density lipoprotein WMD = -9.63 mg/dl; 95%CI, -13.87, -5.39; P < 0.001), fasting blood glucose (FBG) (WMD = -7.74 mg/dl; 95%CI -10.79, -4.70; P < 0.001), insulin (WMD = -3.27 mg/dl; 95%CI -4.46,-2.07; P < 0.001), HbA1c (WMD = -0.45%; 95%CI -0.68, -0.23; P < 0.001), HOMA-IR (WMD = -1.04; 95%CI -1.55, -0.52; P < 0.001), systolic blood pressure (WMD = -5.46 mmHg; 95%CI -8.17, -2.76; P < 0.001), weight (WMD = -0.84; 95%CI -1.34,-0.34; P < 0.001), body mass index (WMD = -0.25 kg/m(2); 95%CI -0.46, -0.04; P = 0.020), while increased high-density lipoprotein (HDL) (WMD = 1.37 mg/dl; 95%CI 0.41,2.23; P = 0.005). The optimal dose of BBR was 1 g/day for TG, TC, and weight, 1.8 g/day for insulin and HOMA-IR, and 5 g/day for HDL. FBG's most efficient time frame was 40 weeks from the beginning of supplementation, whereas DBP and waist circumference was 50 weeks. In conclusion, the lipid profile, FBG balance, obesity parameters, and SBP were improved with BBR supplementation.
C1 [Zamani, Mohammad] Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Clin Nutr, Tehran, Iran.
   [Zarei, Mahtab] Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Cellular & Mol Nutr, Tehran, Iran.
   [Nikbaf-Shandiz, Mahlagha] Tabriz Univ Med Sci, Student Res Comm, Tabriz, Iran.
   [Hosseini, Shabnam] Shahid Beheshti Univ Med Sci, Res Inst Endocrine Sci, Nutr & Endocrine Res Ctr, Tehran, Iran.
   [Shiraseb, Farideh] Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Community Nutr, Tehran, Iran.
   [Asbaghi, Omid] Shahid Beheshti Univ Med Sci, Canc Res Ctr, Tehran, Iran.
   [Asbaghi, Omid] Shahid Beheshti Univ Med Sci, Student Res Comm, Tehran, Iran.
C3 Tehran University of Medical Sciences; Tehran University of Medical
   Sciences; Tabriz University of Medical Science; Shahid Beheshti
   University Medical Sciences; Tehran University of Medical Sciences;
   Shahid Beheshti University Medical Sciences; Shahid Beheshti University
   Medical Sciences
RP Shiraseb, F (corresponding author), Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Community Nutr, Tehran, Iran.; Asbaghi, O (corresponding author), Shahid Beheshti Univ Med Sci, Canc Res Ctr, Tehran, Iran.; Asbaghi, O (corresponding author), Shahid Beheshti Univ Med Sci, Student Res Comm, Tehran, Iran.
EM farideh_shiraseb@yahoo.com; omid.asbaghi@gmail.com
RI hosseini, shabnam/AAS-6180-2021; Zarei, Mahtab/GPP-3942-2022
OI Hosseini, Shabnam/0000-0001-5418-2821; Nikbaf-Shandiz,
   Mahlagha/0009-0001-7996-1597; Zamani, Mohammad/0000-0002-3853-023X;
   Zarei, Mahtab/0000-0003-2876-7847
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NR 120
TC 10
Z9 10
U1 0
U2 11
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD OCT 14
PY 2022
VL 9
AR 1013055
DI 10.3389/fnut.2022.1013055
PG 39
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 5V4IE
UT WOS:000877193500001
PM 36313096
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Rittiphairoj, T
   Pongpirul, K
   Janchot, K
   Mueller, NT
   Li, TJ
AF Rittiphairoj, Thanitsara
   Pongpirul, Krit
   Janchot, Kantima
   Mueller, Noel T.
   Li, Tianjing
TI Probiotics Contribute to Glycemic Control in Patients with Type 2
   Diabetes Mellitus: A Systematic Review and Meta-Analysis
SO ADVANCES IN NUTRITION
LA English
DT Review
DE probiotics; type 2 diabetes mellitus; glycemic control; systematic
   review; meta-analysis
ID BETA-CELL FUNCTION; LIPID PROFILE; DOUBLE-BLIND; FATTY-ACIDS;
   BIFIDOBACTERIUM-LACTIS; INFLAMMATORY MARKERS; INSULIN SENSITIVITY;
   METABOLIC SYNDROME; OXIDATIVE STRESS; SYNBIOTIC BREAD
AB This systematic review aimed to evaluate the effectiveness and safety of probiotics for glycemic control in adults with impaired glucose control, including prediabetes and type 2 diabetes mellitus (T2DM). We searched PubMed, Embase, and Cochrane databases, and trial registries up to February 2019. We included randomized controlled trials (RCTs) of participants with prediabetes or T2DM. Eligible trials compared probiotics versus either placebo, no intervention, or comparison probiotics, or compared synbiotics versus prebiotics. Primary outcomes were mean change in fasting blood glucose (FBG) and glycated hemoglobin (HbA1c) from baseline to short term (<12 wk) and long term (>= 12 wk). We performed meta-analyses using the random-effects model. We included 28 RCTs (1947 participants). Overall, probiotics reduced FBG more than the placebo/no intervention group with a mean difference (MD) of -12.99 mg/dL (95% CI: -2355, -2.42; P value: 0.016) over the short term; and -2.99 mg/dL (95% CI: -5.84, -0.13; P value: 0.040) over the long term. There was also some evidence for reduced HbA1 c in the probiotics group at both short term (MD: -0.17; 95% CI: -037, 0.02; P value: 0.084) and long term (MD: -0.14; 95% CI: -0.34, 0.06; P value: 0.172), however, these did not reach statistical significance possibly because only a few trials reported HbA1c as an outcome. Subgroup analyses showed a greater reduction in HbA1c in participants not receiving insulin therapy than those receiving insulin therapy. Furthermore, the effect of probiotics on the reduction of FBG was more pronounced in participants with FBG >130 mg/dL and those not receiving insulin therapy than their counterparts. Probiotics were also effective in lowering serum cholesterol over the short and long term. In conclusion, we found that probiotics may have a glucose-lowering effect in T2DM participants. The effect appeared to be stronger in participants with poorly controlled diabetes and those not on insulin therapy.
C1 [Rittiphairoj, Thanitsara; Mueller, Noel T.; Li, Tianjing] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA.
   [Rittiphairoj, Thanitsara; Pongpirul, Krit] Chulalongkorn Univ, Dept Prevent & Social Med, Fac Med, Bangkok, Thailand.
   [Pongpirul, Krit] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Int Hlth, Baltimore, MD 21205 USA.
   [Janchot, Kantima] Panacee Grp Co Ltd, Bangkok, Thailand.
   [Mueller, Noel T.] Welch Ctr Prevent Epidemiol & Clin Res, Baltimore, MD USA.
   [Li, Tianjing] Univ Colorado, Sch Med, Dept Ophthalmol, Anschutz Med Campus, Aurora, CO USA.
   [Rittiphairoj, Thanitsara] Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD USA.
C3 Johns Hopkins University; Johns Hopkins Bloomberg School of Public
   Health; Chulalongkorn University; Johns Hopkins University; Johns
   Hopkins Bloomberg School of Public Health; University of Colorado
   System; University of Colorado Anschutz Medical Campus; Johns Hopkins
   University; Johns Hopkins Bloomberg School of Public Health
RP Pongpirul, K (corresponding author), Johns Hopkins Bloomberg Sch Publ Hlth, Dept Int Hlth, Baltimore, MD 21205 USA.
EM doctorkrit@gmail.com
RI Pongpirul, Krit/H-4064-2019
OI Pongpirul, Krit/0000-0003-3818-9761; Li, Tianjing/0000-0001-5371-4558
FU Prince Mahidol Award Foundation under the Royal Patronage; Thailand
   Research Fund [RDG6150124]
FX TR was a visiting scholar at Johns Hopkins Bloomberg School of Public
   Health when the work was performed. Her scholarship was funded by the
   Prince Mahidol Award Foundation under the Royal Patronage. The project
   received partial funding support from the Thailand Research Fund
   (RDG6150124). The sponsors were not involved in the data analysis, data
   interpretation, or manuscript preparation.
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NR 57
TC 74
Z9 74
U1 1
U2 42
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 2161-8313
EI 2156-5376
J9 ADV NUTR
JI Adv. Nutr.
PD MAY
PY 2021
VL 12
IS 3
BP 722
EP 734
DI 10.1093/advances/nmaa133
PG 13
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA SS0XE
UT WOS:000661465200013
PM 33126241
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Wlodarczyk, M
   Ciebiera, M
   Nowicka, G
AF Wlodarczyk, Marta
   Ciebiera, Michal
   Nowicka, Grazyna
TI TNF-α G-308A genetic variants, serum CRP-hs concentration and DNA
   damage in obese women
SO MOLECULAR BIOLOGY REPORTS
LA English
DT Article
DE DNA damage; Obesity; CRP; TNF gene; Polymorphism
ID NECROSIS-FACTOR-ALPHA; C-REACTIVE PROTEIN; TUMOR-NECROSIS; OXIDATIVE
   STRESS; METABOLIC SYNDROME; PROMOTER POLYMORPHISM; RISK-FACTORS;
   INSULIN-RESISTANCE; ADIPOSE-TISSUE; CARDIOVASCULAR-DISEASE
AB Obesity is associated with inflammation, which can disturb genome stability. Tumor necrosis factor (TNF-alpha) polymorphism was found to affect TNF-alpha protein production and inflammation. Therefore, the present study illustrates the relationship between TNF-alpha polymorphism, the degree of inflammation assessed by serum high sensitivity C-reactive protein concentration (CRP-hs) and basal DNA damage in patients with obesity (BMI 30-34.9 kg/m(2)) and control subjects with proper body mass (BMI<25 kg/m(2)). A total of 115 participants (75 obese premenopausal women; and 40 age-, and gender-matched controls) were included. Biochemical parameters (serum concentrations of total-cholesterol, HDL-cholesterol, LDL- cholesterol, triglycerides, glucose, apolipoprotein AI, CRP-hs) and endogenous DNA damage (determined by comet assay) were measured. TNF-alpha G-308A polymorphism (rs1800629) was analyzed by PCR-RFLP (PCR-restriction fragments length polymorphism). An effect of TNF-alpha genotype on serum CRP-hs concentration was noted (p=0.031). In general, carriers of the rare A allele of the TNF-alpha G-308A polymorphism had significantly lower endogenous DNA damage and serum CRP-hs concentrations than GG homozygotes, however, the protective effect of the A allele was especially visible in non-obese women. Serum CRP-hs concentrations and levels of DNA damage (% DNA in tail) were significantly higher in obese than in controls (p=0.001 and p<0.0001, respectively). The adjusted multiple linear regression analyses revealed a significant, independent impact of obesity on DNA damage (p=0.00000) and no effect of other covariates i.e. age, TNF-alpha genotype and serum CRP-hs concentration. Our study showed that obesity has a significant impact on the levels of endogenous DNA damage. Obesity abolished the protective effect of A allele of the TNF-alpha G-308A polymorphism on DNA damage and on inflammation development observed in non-obese A allele carriers.
C1 [Wlodarczyk, Marta; Nowicka, Grazyna] Med Univ Warsaw, Fac Pharm, Dept Biochem & Pharmacogen, Div Lab Med, Banacha 1B, PL-02097 Warsaw, Poland.
   [Wlodarczyk, Marta; Nowicka, Grazyna] Med Univ Warsaw, Ctr Preclin Res, Banacha 1B, PL-02097 Warsaw, Poland.
   [Ciebiera, Michal] Ctr Postgrad Med Educ, Dept Obstet & Gynecol 2, Ceglowska 80, PL-01809 Warsaw, Poland.
C3 Medical University of Warsaw; Medical University of Warsaw; Centre of
   Postgraduate Medical Education - Poland
RP Wlodarczyk, M (corresponding author), Med Univ Warsaw, Fac Pharm, Dept Biochem & Pharmacogen, Div Lab Med, Banacha 1B, PL-02097 Warsaw, Poland.; Wlodarczyk, M (corresponding author), Med Univ Warsaw, Ctr Preclin Res, Banacha 1B, PL-02097 Warsaw, Poland.
EM marta.wlodarczyk@wum.edu.pl; michal.ciebiera@gmail.com;
   grazyna.nowicka@wum.edu.pl
RI Nowicka, Grażyna/U-6222-2019; Wlodarczyk, Marta/N-7700-2018
OI Ciebiera, Michal/0000-0001-5780-5983; Nowicka,
   Grazyna/0000-0001-9556-6813; Wlodarczyk, Marta/0000-0003-1545-2547
FU National Science Centre [NN404087940, N404042/32/0945]; European
   Union-the European Regional Development Fund within the Operational
   Program (Innovative economy for 2007-2013)
FX This work was supported by the National Science Centre (Grant Nos.
   NN404087940 and N404042/32/0945) and carried out with the use of the
   CePT infrastructure financed by the European Union-the European Regional
   Development Fund within the Operational Program (Innovative economy for
   2007-2013).
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NR 108
TC 9
Z9 11
U1 0
U2 2
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0301-4851
EI 1573-4978
J9 MOL BIOL REP
JI Mol. Biol. Rep.
PD FEB
PY 2020
VL 47
IS 2
BP 855
EP 866
DI 10.1007/s11033-019-04764-0
PG 12
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA KP9GH
UT WOS:000516538600002
PM 30900134
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Harari, A
   Coster, ACF
   Jenkins, A
   Xu, AM
   Greenfield, JR
   Harats, D
   Shaish, A
   Samocha-Bonet, D
AF Harari, Ayelet
   Coster, Adelle C. F.
   Jenkins, Arthur
   Xu, Aimin
   Greenfield, Jerry R.
   Harats, Dror
   Shaish, Aviv
   Samocha-Bonet, Dorit
TI Obesity and Insulin Resistance Are Inversely Associated with Serum and
   Adipose Tissue Carotenoid Concentrations in Adults
SO JOURNAL OF NUTRITION
LA English
DT Article
DE carotenoids; retinol; obesity; insulin resistance; dietary carotene;
   adipose tissue carotenoids; serum carotenoids
ID PROLIFERATION-ACTIVATED RECEPTOR; VITAMIN-A; BETA-CAROTENE;
   CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; REPRESSES OBESITY;
   DIABETES-MELLITUS; OXIDATIVE STRESS; ALPHA-TOCOPHEROL; PLASMA
AB Background: Low tissue concentrations of carotenoids have been suggested to contribute to insulin resistance in obesity.
   Objectives: The objectives of the study were to 1) evaluate the relations of adipose tissue and serum carotenoids with body fat, abdominal fat distribution, muscle, adipose tissue and liver insulin resistance, and dietary intake; 2) evaluate the relations and distributions of carotenoids detected in adipose tissue and serum; and 3) compare serum carotenoids and retinol concentrations in subjects with and without obesity.
   Methods: Post hoc analysis of serum and adipose tissue carotenoids in individuals [n = 80; 31 men, 49 women; age (mean +/- SEM): 51.4 +/- 1.1 y] who participated in 2 separate studies conducted at the Clinical Research Facility at the Garvan Institute of Medical Research (Sydney) between 2008 and 2013. Retinol, alpha-carotene, beta-carotene, zeta-carotene, lutein, lycopene, phytoene, and phytofluene were measured using HPLC. Body composition was measured by dualenergy X-ray absorptiometry. Insulin resistance was measured by 2-step hyperinsulinemic-euglycemic clamps with deuterated glucose (n = 64), and subcutaneous and visceral abdominal volume and liver and pancreatic fat by MRI (n = 60). Periumbilical subcutaneous fat biopsy was performed and carotenoids and retinol measured in the tissue (n = 16).
   Results: We found that zeta-carotene, phytoene, and phytofluene were stored in considerable amounts in adipose tissue (25% of adipose tissue carotenoids). Carotenoid concentrations in adipose tissue and serum correlated significantly, but they followed different distributions: zeta-carotene was 3-fold higher in adipose tissue compared with serum, while lutein and lycopene made up 20% and 21% of serum carotenoids compared with 2% and 12% of adipose tissue carotenoids, respectively. Liver (P = 0.028) and adipose tissue (P = 0.023), but not muscle (P = 0.16), insulin resistance correlated inversely with many of the serum carotenoids.
   Conclusions: Multiple serum and adipose tissue carotenoids are associated with favorable metabolic traits, including insulin sensitivity in liver and adipose tissue in humans.
C1 [Harari, Ayelet; Harats, Dror; Shaish, Aviv] Sheba Med Ctr, Bert W Strassburger Lipid Ctr, Tel Hashomer, Israel.
   [Coster, Adelle C. F.] UNSW, Sch Math & Stat, Sydney, NSW, Australia.
   [Jenkins, Arthur; Greenfield, Jerry R.; Samocha-Bonet, Dorit] Garvan Inst Med Res, Diabet & Metab Div, Sydney, NSW, Australia.
   [Jenkins, Arthur] Univ Wollongong, Sch Med, Wollongong, NSW, Australia.
   [Xu, Aimin] Univ Hong Kong, State Key Lab Pharmaceut Biotechnol, Hong Kong, Peoples R China.
   [Greenfield, Jerry R.; Samocha-Bonet, Dorit] UNSW, Fac Med, St Vincents Clin Sch, Sydney, NSW, Australia.
   [Greenfield, Jerry R.] St Vincents Hosp, Dept Endocrinol, Sydney, NSW, Australia.
   [Greenfield, Jerry R.] St Vincents Hosp, Diabet Ctr, Sydney, NSW, Australia.
   [Harats, Dror] Tel Aviv Univ, Sackler Sch Med, Tel Aviv, Israel.
   [Shaish, Aviv] Achva Acad Coll, Arugot, Israel.
C3 Tel Aviv University; Chaim Sheba Medical Center; University of New South
   Wales Sydney; Garvan Institute of Medical Research; University of
   Wollongong; University of Hong Kong; University of New South Wales
   Sydney; NSW Health; St Vincents Hospital Sydney; NSW Health; St Vincents
   Hospital Sydney; Tel Aviv University; Sackler Faculty of Medicine
RP Samocha-Bonet, D (corresponding author), Garvan Inst Med Res, Diabet & Metab Div, Sydney, NSW, Australia.; Samocha-Bonet, D (corresponding author), UNSW, Fac Med, St Vincents Clin Sch, Sydney, NSW, Australia.
EM d.samochabonet@garvan.org.au
RI Jenkins, Arthur/HTP-4062-2023; Coster, Adelle/A-7234-2013; Jenkins,
   Arthur/D-4533-2012
OI Coster, Adelle/0000-0002-5572-6832; Samocha-Bonet,
   Dorit/0000-0001-9422-7852; Jenkins, Arthur/0000-0003-1310-264X
FU Diabetes Australia Research Program; Garvan Research Foundation
FX The clinical studies were funded by grants from the Diabetes Australia
   Research Program and the Garvan Research Foundation.
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NR 51
TC 58
Z9 61
U1 0
U2 23
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0022-3166
EI 1541-6100
J9 J NUTR
JI J. Nutr.
PD JAN
PY 2020
VL 150
IS 1
BP 38
EP 46
DI 10.1093/jn/nxz184
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA KK8SY
UT WOS:000513007600006
PM 31504714
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Eng, JY
   Moy, FM
   Bulgiba, A
   Rampal, S
AF Eng, Jui-Yee
   Moy, Foong-Ming
   Bulgiba, Awang
   Rampal, Sanjay
TI Consistency and Generalizability of Dietary Patterns in a Multiethnic
   Working Population
SO JOURNAL OF THE ACADEMY OF NUTRITION AND DIETETICS
LA English
DT Article
DE Dietary pattern; Consistency; Generalizability; Multiethnic
ID EXPLORATORY FACTOR-ANALYSIS; LIFE-STYLE FACTORS; CANCER RISK;
   NUTRITIONAL EPIDEMIOLOGY; METABOLIC SYNDROME; MEASUREMENT ERROR;
   ETHNIC-GROUPS; YOUNG-ADULTS; FOOD; HEALTH
AB Background Dietary pattern analysis is a complementary method to nutrient analysis in evaluating overall diet-disease hypotheses. Although studies have been conducted to derive dietary patterns among Malaysians, their consistency across subgroups has not been examined.
   Objective The study aimed to derive dietary patterns empirically and to examine the consistency and generalizability of patterns across sex, ethnicity, and urban status in a working population.
   Design This was a cross-sectional study using data from the Clustering of Lifestyle Risk Factors and Understanding its Association with Stress on Health and Well-Being among School Teachers in Malaysia study collected between August 2014 and November 2015. Dietary intake was assessed using a food frequency questionnaire, and dietary patterns were derived using factor analysis.
   Participants/setting Participants were teachers from selected public schools from three states in Peninsular Malaysia (n=4,618).
   Main outcome measures Dietary patterns derived using factor analysis.
   Statistical analyses performed Separate factor analysis was conducted by sex, ethnicity, and urban status to identify dietary patterns. Eigenvalue >2, scree plot, Velicer's minimum average partial analysis, and Horn's parallel analysis were used to determine the number of factors to retain. The interpretability of each dietary pattern was evaluated. The consistency and generalizability of dietary patterns across subgroups were assessed using the Tucker congruence coefficient.
   Results There was no subgroup-specific dietary pattern found. Thus, dietary patterns were derived using the pooled sample in the final model. Two dietary patterns (Western and Prudent) were derived. The Western dietary pattern explained 15.4% of total variance, characterized by high intakes of refined grains, animal-based foods, added fat, and sugar-sweetened beverages as well as fast food. The Prudent dietary pattern explained 11.1% of total variance and was loaded with pulses, legumes, vegetables, and fruits.
   Conclusions The derived Western and Prudent dietary patterns were consistent and generalizable across subgroups of sex, ethnicity, and urban status. Further research is needed to explore associations between these dietary patterns and chronic diseases.
C1 [Eng, Jui-Yee; Moy, Foong-Ming; Bulgiba, Awang; Rampal, Sanjay] Univ Malaya, Julius Ctr Univ Malaya, Dept Social & Prevent Med, Fac Med, Kuala Lumpur 50603, Malaysia.
C3 Universiti Malaya
RP Moy, FM (corresponding author), Univ Malaya, Julius Ctr Univ Malaya, Dept Social & Prevent Med, Fac Med, Kuala Lumpur 50603, Malaysia.
EM moyfm@um.edu.my
RI Rampal, Sanjay/B-9691-2010; Bulgiba, Awang/B-8271-2010; Moy, Foong
   Ming/B-7899-2010
OI Bulgiba, Awang/0000-0002-5313-0445; ENG, JUI YEE/0000-0003-0131-5189;
   Moy, Foong Ming/0000-0002-0306-4419
FU Malaysia Ministry of Higher Education High Impact Research Grant
   [H-20001-00-E2000069]; University of Malaya [PG060-2013A]
FX This work was funded by a Malaysia Ministry of Higher Education High
   Impact Research Grant (no. H-20001-00-E2000069) and Postgraduate
   Research Grant from the University of Malaya (no. PG060-2013A).
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NR 76
TC 10
Z9 11
U1 1
U2 8
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 2212-2672
EI 2212-2680
J9 J ACAD NUTR DIET
JI J. Acad. Nutr. Diet.
PD JUL
PY 2018
VL 118
IS 7
BP 1249
EP +
DI 10.1016/j.jand.2018.01.014
PG 17
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA GK8OY
UT WOS:000436487300011
PM 29615325
DA 2025-06-11
ER

PT J
AU Woo, HJ
   Reifman, J
AF Woo, Hyung Jun
   Reifman, Jaques
TI Genetic interaction effects reveal lipid-metabolic and inflammatory
   pathways underlying common metabolic disease risks
SO BMC MEDICAL GENOMICS
LA English
DT Article
DE Metabolic syndrome; Type 2 diabetes; Coronary artery disease;
   Hypertension; Epistasis; Genome-wide association studies
ID GENOME-WIDE ASSOCIATION; CORONARY-ARTERY-DISEASE; PROTEIN SI-CLP;
   SUSCEPTIBILITY LOCUS; BLOOD-PRESSURE; IDENTIFIES 6; BETA-CELL; T-CELLS;
   MACROPHAGES; ATHEROSCLEROSIS
AB Background: Common metabolic diseases, including type 2 diabetes, coronary artery disease, and hypertension, arise from disruptions of the body's metabolic homeostasis, with relatively strong contributions from genetic risk factors and substantial comorbidity with obesity. Although genome-wide association studies have revealed many genomic loci robustly associated with these diseases, biological interpretation of such association is challenging because of the difficulty in mapping single-nucleotide polymorphisms (SNPs) onto the underlying causal genes and pathways. Furthermore, common diseases are typically highly polygenic, and conventional single variant-based association testing does not adequately capture potentially important large-scale interaction effects between multiple genetic factors.
   Methods: We analyzed moderately sized case-control data sets for type 2 diabetes, coronary artery disease, and hypertension to characterize the genetic risk factors arising from non-additive, collective interaction effects, using a recently developed algorithm (discrete discriminant analysis). We tested associations of genes and pathways with the disease status while including the cumulative sum of interaction effects between all variants contained in each group.
   Results: In contrast to non-interacting SNP mapping, which produced few genome-wide significant loci, our analysis revealed extensive arrays of pathways, many of which are involved in the pathogenesis of these metabolic diseases but have not been directly identified in genetic association studies. They comprised cell stress and apoptotic pathways for insulin-producing beta-cells in type 2 diabetes, processes covering different atherosclerotic stages in coronary artery disease, and elements of both type 2 diabetes and coronary artery disease risk factors (cell cycle, apoptosis, and hemostasis) associated with hypertension.
   Conclusions: Our results support the view that non-additive interaction effects significantly enhance the level of common metabolic disease associations and modify their genetic architectures and that many of the expected genetic factors behind metabolic disease risks reside in smaller genotyping samples in the form of interacting groups of SNPs.
C1 [Woo, Hyung Jun; Reifman, Jaques] US Army, Med Res & Mat Command, Biotechnol High Performance Comp Software Applica, Telemed & Adv Technol Res Ctr, Ft Detrick, MD 21702 USA.
RP Reifman, J (corresponding author), US Army, Med Res & Mat Command, Biotechnol High Performance Comp Software Applica, Telemed & Adv Technol Res Ctr, Ft Detrick, MD 21702 USA.
EM jaques.reifman.civ@mail.mil
OI Woo, Hyung Jun/0000-0003-3220-2064
FU U.S. Army Medical Research and Materiel Command (Ft. Detrick, Maryland)
FX This work was supported by the U.S. Army Medical Research and Materiel
   Command (Ft. Detrick, Maryland).
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NR 86
TC 8
Z9 9
U1 0
U2 1
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1755-8794
J9 BMC MED GENOMICS
JI BMC Med. Genomics
PD JUN 20
PY 2018
VL 11
AR 54
DI 10.1186/s12920-018-0373-7
PG 15
WC Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Genetics & Heredity
GA GK1MP
UT WOS:000435881600001
PM 29925367
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Lu, J
   Jiao, ZX
   Yu, Y
   Zhang, C
   He, X
   Li, Q
   Xu, D
   Wang, H
AF Lu, Juan
   Jiao, Zhexiao
   Yu, Ying
   Zhang, Chong
   He, Xia
   Li, Qiang
   Xu, Dan
   Wang, Hui
TI Programming for increased expression of hippocampal GAD67 mediated the
   hypersensitivity of the hypothalamic-pituitary-adrenal axis in male
   offspring rats with prenatal ethanol exposure
SO CELL DEATH & DISEASE
LA English
DT Article
ID GLUTAMIC-ACID DECARBOXYLASE; GLUCOCORTICOID-RECEPTOR; METABOLIC
   SYNDROME; TRANSCRIPTION FACTORS; GROWTH-RETARDATION; BODY-COMPOSITION;
   DNA METHYLATION; BLOOD-PRESSURE; STRESS; GABA
AB An imbalance of excitatory and inhibitory signals in the brain has been proposed to be one of the main pathological features of various diseases related to hypothalamic-pituitary-adrenal axis (HPAA) dysfunction. Excessive glutamate release induces neuronal excitotoxicity, while glutamic acid decarboxylase (GAD) 67 promotes the transformation of excessive glutamate to.-aminobutyric acid (GABA). Our previous studies demonstrated that prenatal ethanol exposure (PEE) causes foetal over-exposure to maternal corticosterone and hypersensitivity of the HPAA after birth, but its intrauterine programming mechanism is unknown. In this study, PEE was shown to lead to an enhanced potential excitatory ability of the hypothalamus and hypersensitivity of the HPAA, as well as mild abnormal hippocampal morphology, demethylation of the -1019 to -691-bp region in the hippocampal GAD67 promoter and upregulation of GAD67 expression accompanied by a reduction in glutamatergic neurons and increase in GABAergic neurons in PEE male offspring. Similar changes were also found in PEE male foetal rats. Furthermore, corticosterone increased the expression of the glucocorticoid receptor (GR) and GAD67 in foetal hippocampal H19-7 cells in a concentration-dependent manner, accompanied by demethylation of the GAD67 promoter, a decrease in glutamatergic neurons and increase in GABAergic neurons. The GR inhibitor, mifepristone, reversed the effects of corticosterone on H19-7 cells. These results suggested that PEE-induced excessive corticosterone can lead to upregulation of GAD67 through epigenetic modification mediated by the GR in the male foetal hippocampus, thereby weakening the negative regulation of the HPAA by the hippocampus and increasing the potential excitatory ability of the hypothalamus. These changes persisted until after birth, resulting in hypersensitivity of the HPAA. However, gender differences were observed in the hippocampal development, morphology and GAD67 expression associated with PEE. Programming for the increased expression of hippocampal GAD67 is a potential mechanism responsible for the hypersensitivity of the HPAA in PEE male rats.
C1 [Lu, Juan; Jiao, Zhexiao; Zhang, Chong; He, Xia; Xu, Dan; Wang, Hui] Wuhan Univ, Basic Med Sch, Dept Pharmacol, Wuhan, Hubei, Peoples R China.
   [Yu, Ying; Xu, Dan; Wang, Hui] Hubei Prov Key Lab Dev Originated Dis, Wuhan, Hubei, Peoples R China.
   [Yu, Ying] Wuhan Univ, Renmin Hosp, Dept Neurol, Wuhan 430060, Hubei, Peoples R China.
   [Lu, Juan; Li, Qiang] Gansu Univ Chinese Med, Gansu Prov Hosp TCM, Lanzhou 730050, Gansu, Peoples R China.
C3 Wuhan University; Wuhan University; Gansu University of Chinese Medicine
RP Xu, D; Wang, H (corresponding author), Wuhan Univ, Basic Med Sch, Dept Pharmacol, Wuhan, Hubei, Peoples R China.; Xu, D; Wang, H (corresponding author), Hubei Prov Key Lab Dev Originated Dis, Wuhan, Hubei, Peoples R China.
EM xuyidan70188@whu.edu.cn; wanghui19@whu.edu.cn
RI LI, QI/IUM-8577-2023; lu, juan/MEP-8121-2025
FU National Natural Science Foundation of China [81660544, 81430089,
   81673524, 81671472]; National Key Research and Development Programme of
   China [2017YFC1001300]; Hubei Province Health and Family Planning
   Scientific Research Project [WJ2017C0003]
FX This work was supported by the National Natural Science Foundation of
   China (No. 81660544, 81430089, 81673524 and 81671472), the National Key
   Research and Development Programme of China (No. 2017YFC1001300), and
   Hubei Province Health and Family Planning Scientific Research Project
   (No. WJ2017C0003).
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NR 58
TC 25
Z9 25
U1 2
U2 19
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 2041-4889
J9 CELL DEATH DIS
JI Cell Death Dis.
PD MAY 31
PY 2018
VL 9
AR 659
DI 10.1038/s41419-018-0663-1
PG 17
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA GH8ME
UT WOS:000433921800002
PM 29855476
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Ortega, RM
   Rodríguez-Rodríguez, E
   Aparicio, A
   Jiménez, AI
   López-Sobaler, AM
   González-Rodríguez, LG
   Andrés, P
AF Ortega, R. M.
   Rodriguez-Rodriguez, E.
   Aparicio, A.
   Jimenez, A. I.
   Lopez-Sobaler, A. M.
   Gonzalez-Rodriguez, L. G.
   Andres, P.
TI Poor zinc status is associated with increased risk of insulin resistance
   in Spanish children
SO BRITISH JOURNAL OF NUTRITION
LA English
DT Article
DE Zinc status; Zinc intake; Insulin resistance; Children
ID BODY-MASS INDEX; METABOLIC SYNDROME; GLUCOSE-TOLERANCE; OBESE CHILDREN;
   OXIDATIVE STRESS; ABDOMINAL FAT; SENSITIVITY; ADOLESCENTS;
   SUPPLEMENTATION; GROWTH
AB Zn plays a key role in the synthesis and action of insulin. The aim of the present work was to determine whether a poorer Zn status was associated with insulin resistance in a group of 357 Spanish schoolchildren. Zn intake was determined by using a 3 d food record (i.e. Sunday to Tuesday). The body weight, height and waist and hip circumferences of all subjects were recorded and fasting plasma glucose, insulin and Zn concentrations were determined. Insulin resistance was determined using the homoeostasis model assessment (HOMA) marker. Children (11.5%) with Zn deficiency (serum Zn concentration <10.7 mu mol/l) had higher HOMA values than those with a more satisfactory Zn status (1.73 (SD 0.93)) compared with 1.38 (SD 0.90; P<0.05). An inverse correlation was found between the HOMA value and the serum Zn concentration (r=0.149, P<0.05). The risk of having a greater insulin resistance value (HOMA greater than the 75th percentile) increased with age (OR 1.438; 95% CI 1.021, 2.027) and BMI (OR 1.448; 95% CI 1.294, 1.619) and decreased as Zn serum levels increased (OR 0.908; 95% CI 0.835, 0.987; P<0.001). Moreover, an inverse relationship was observed between HOMA values and Zn dietary density(r=0.122), and the Zn intakes of male children with a HOMA value of >3.16 made a significantly smaller contribution to the coverage of those recommended (59.7 (SD 14.7)%) than observed in children with lower HOMA values (73.6 (SD 18.2) %; P<0.05). Taking into account that Zn intake was below than that recommended in 89.4% of the children, it would appear that increasing the intake of Zn could improve the health and nutritional status of these children, and thus contribute to diminish problems of insulin resistance.
C1 [Ortega, R. M.; Aparicio, A.; Lopez-Sobaler, A. M.; Gonzalez-Rodriguez, L. G.] Univ Complutense Madrid, Fac Farm, Dept Nutr, E-28040 Madrid, Spain.
   [Ortega, R. M.; Rodriguez-Rodriguez, E.; Aparicio, A.; Jimenez, A. I.; Lopez-Sobaler, A. M.; Gonzalez-Rodriguez, L. G.; Andres, P.] Univ Complutense Madrid, UCM Res Grp 920030, E-28040 Madrid, Spain.
   [Rodriguez-Rodriguez, E.; Andres, P.] Univ Complutense Madrid, Fac Farm, Secc Dept Quim Analit, E-28040 Madrid, Spain.
   [Jimenez, A. I.] Hosp Infantil Univ Nino Jesus, Madrid 28009, Spain.
C3 Complutense University of Madrid; Complutense University of Madrid;
   Complutense University of Madrid
RP Ortega, RM (corresponding author), Univ Complutense Madrid, Fac Farm, Dept Nutr, E-28040 Madrid, Spain.
EM rortega@farm.ucm.es
RI Ortega, Rosa/S-5760-2016; Lopez-Sobaler, Ana M/I-3589-2016; Gonzalez
   Rodriguez, Liliana G./H-4386-2017; Aparicio, Aranzazu/I-9891-2016;
   Rodriguez-Rodriguez, Elena/I-1836-2017; Jimenez, Ana Isabel/I-2750-2017
OI Lopez-Sobaler, Ana M/0000-0002-4133-1450; Gonzalez Rodriguez, Liliana
   G./0000-0002-7741-5488; ORTEGA ANTA, ROSA MARIA/0000-0003-3837-9450;
   Perea Sanchez, Jose Miguel/0000-0003-3297-5614; Aparicio,
   Aranzazu/0000-0001-8500-9802; Rodriguez-Rodriguez,
   Elena/0000-0003-3513-4642; ANDRES, PEDRO/0000-0001-7850-7432; Jimenez,
   Ana Isabel/0000-0002-9868-1013
FU FISS [PI060318]; Creation and Consolidation Program Research Group at
   the Complutense University of Madrid, Madrid [GR58/08, 4120787]
FX This study was supported by the project FISS (PI060318) and the
   'Creation and Consolidation Program Research Group at the Complutense
   University of Madrid, Madrid' (ref. GR58/08; code 4120787). None of the
   authors had any personal or financial conflict of interest. R. M. O., A.
   M. L.-S., E. R.-R. and A. A. contributed to the study design and E.
   R.-R., A. A., A. I. J. and L. G. G. R. performed the data collection. R.
   M. O., A. M. L.-S., E. R.-R., A. A. and P. A. were involved in data
   analysis and the interpretation of results. R. M. O., A. A., A. I. J.
   and P. A. contributed to the writing of the manuscript.
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NR 48
TC 34
Z9 39
U1 0
U2 12
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1145
EI 1475-2662
J9 BRIT J NUTR
JI Br. J. Nutr.
PD FEB
PY 2012
VL 107
IS 3
BP 398
EP 404
DI 10.1017/S0007114511003114
PG 7
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 886UL
UT WOS:000299879300010
PM 22277170
OA Bronze
DA 2025-06-11
ER

PT J
AU Taher, A
   Das Trisha, A
   Ahmed, S
   Begum, J
   Sinha, F
   Sarna, NZ
   Ali, N
AF Taher, Abu
   Das Trisha, Aporajita
   Ahmed, Shamim
   Begum, Jannat
   Sinha, Falguni
   Sarna, Nusrat Zaman
   Ali, Nurshad
TI Investigating the Relationship Between Serum Uric Acid and Dyslipidemia
   in Young Adults in Bangladesh
SO ENDOCRINOLOGY DIABETES & METABOLISM
LA English
DT Article
DE Bangladesh; cardiovascular disease; dyslipidemia; serum uric acid; young
   adults
ID DENSITY-LIPOPROTEIN CHOLESTEROL; METABOLIC SYNDROME; OXIDATIVE STRESS;
   HYPERURICEMIA; DISEASE; RISK; PREVALENCE; PROTEIN; ATHEROSCLEROSIS;
   ACCUMULATION
AB Objectives: While some reports exist on the relationship between serum uric acid (SUA) and dyslipidemia in adults, there is limited information available regarding young adults. This study aimed to evaluate the relationship between SUA and dyslipidemia, as well as its components, among young adults in Bangladesh. Methods: This study consisted of 458 participants (281 male and 177 female) aged between 18 and 30 years. The levels of SUA, fasting blood glucose and lipid profile (TG, TC, HDL-C and LDL-C) were measured using standard colorimetric methods. Bivariate logistic regression modelling was used to examine the relationship between SUA and dyslipidemia and its components. Results: The overall prevalence of hyperuricemia was 24% with 27.6% in males and 18.6% in females. Males had a higher mean SUA level (6.6 +/- 1.5 mg/dL) than females (5.3 +/- 1.2 mg/dL) (p < 0.001). The prevalence of dyslipidemia was 74.2% with 83.2% in male and 59.8% in female subjects. The prevalence of hypertriglyceridemia, hypercholesterolemia, high LDL-C and low HDL-C was 30.1%, 26.2%, 28.8% and 64.8%, respectively. There was an increasing trend in the level and prevalence of elevated lipid profile markers across the SUA quartiles (p < 0.001). SUA level showed a positive correlation with TG, TC and LDL-C and a negative correlation with HDL (p < 0.001). In regression analysis, a significant association was found between SUA and dyslipidemia in all participants as well as in the male-female groups separately (at least p < 0.05). Furthermore, a significant association (p < 0.001) was found between SUA and individual lipid components in the regression models. Conclusion: Dyslipidemia and its components were more prevalent in individuals with hyperuricemia than in those without. This study identified a significant association between SUA and dyslipidemia in young adults in Bangladesh. Further research is needed to explore the mechanisms behind this association.
C1 [Taher, Abu; Das Trisha, Aporajita; Ahmed, Shamim; Begum, Jannat; Sinha, Falguni; Sarna, Nusrat Zaman; Ali, Nurshad] Shahjalal Univ Sci & Technol, Dept Biochem & Mol Biol, Sylhet, Bangladesh.
C3 Shahjalal University of Science & Technology (SUST)
RP Ali, N (corresponding author), Shahjalal Univ Sci & Technol, Dept Biochem & Mol Biol, Sylhet, Bangladesh.
EM nur_rubd@yahoo.com
RI Ali, Nurshad/R-7452-2018
FU SUST Research Centre [LS/2023/1/02]
FX The authors express gratitude to all volunteers for their cooperation in
   the study. This research was supported by an internal grant from the
   SUST Research Centre (LS/2023/1/02).
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NR 57
TC 0
Z9 0
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
EI 2398-9238
J9 ENDOCRIN DIAB METAB
JI Endocrinol. Diabetes Metab.
PD MAY
PY 2025
VL 8
IS 3
AR e70063
DI 10.1002/edm2.70063
PG 11
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA 3DL9G
UT WOS:001497719400001
PM 40420797
DA 2025-06-11
ER

PT J
AU Acevedo, S
   Andrade, JM
AF Acevedo, Sofia
   Andrade, Jeanette M.
TI Effects of a spice-blended honey muffin on salivary inflammation markers
   in adults with obesity: a feasibility trial
SO ANNALS OF MEDICINE
LA English
DT Article
DE Chronic inflammation; turmeric; IL-6; cRP; obesity
ID RANDOMIZED CONTROLLED-TRIAL; METABOLIC SYNDROME; OXIDATIVE STRESS;
   DOUBLE-BLIND; CURCUMIN; ANTIOXIDANT; EXPRESSION; MORTALITY; PLASMA;
   AGENT
AB Background Obesity is considered a low-grade chronically inflamed state that contributes to communicable chronic diseases. This inflammation may be modulated by consuming spices like turmeric daily. However, few studies have looked at the inclusion of spice within whole foods. Objective The purpose of this feasibility pre/posttrial was to assess the influence of turmeric in a muffin on salivary IL-6 and CRP in adults who were obese. Methods Participants consumed one, 60-gram muffin containing 3 g turmeric for 10 days. Participants provided a urinary sample at baseline, a 2-ml saliva sample, and a 30-day food frequency and spice consumption questionnaire at baseline and post-trial. A one-sample t-test was conducted using SAS v 9.4 with significance determined at p < 0.05. Results A total of 14 participants, average BMI of 32.16 kg/m(2) with 10 identifying as female, completed the trial after 5 dropped due to various reasons. The visit lengths and collection of data with participants adhering to the instructions were deemed a success. There was a significant decrease in salivary IL-6 (p = 0.03) but no statistical difference in salivary CRP (p = 0.46). Participants consumed fruits and vegetables at least once daily, chicken and eggs 5-6 times per week, and beef, pork, and fish at least once per week. Participants consumed chili pepper, garlic, cinnamon, cilantro, and ginger at least once per week. No changes were observed in dietary/spice habits during this trial. Conclusion The feasibility pre/post study revealed that consumption of a muffin with turmeric reduced at least salivary IL-6 in 10 days. Modifications to the study design such as lengthier trial time to assess the impact of this muffin on CRP is necessary prior to implementing larger-scale randomized control trials.
   KEY MESSAGES Chronic inflammation in obese patients can be modulated with the use of spices. The consumption of a spiced muffin with turmeric (2mg) reduced salivary IL-6 in 10 days (p = 0.03).
C1 [Acevedo, Sofia; Andrade, Jeanette M.] Univ FL Food Sci, Gainesville, FL USA.
   [Acevedo, Sofia; Andrade, Jeanette M.] Human Nutr Dept, Gainesville, FL USA.
RP Andrade, JM (corresponding author), Univ FL Food Sci, Gainesville, FL 32611 USA.; Andrade, JM (corresponding author), Human Nutr Dept, Gainesville, FL 32611 USA.
EM jandrade1@ufl.edu
RI Andrade, Juan/JMC-0573-2023
OI Andrade, Jeanette/0000-0003-4452-4546; Acevedo,
   Sofia/0009-0007-4892-8181
FU McNair's Scholars program
FX Partial funding was provided by McNair's Scholars program.
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NR 65
TC 0
Z9 0
U1 0
U2 2
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0785-3890
EI 1365-2060
J9 ANN MED
JI Ann. Med.
PD DEC 12
PY 2023
VL 55
IS 2
AR 2245325
DI 10.1080/07853890.2023.2245325
PG 11
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA O7ZE5
UT WOS:001045944800001
PM 37566728
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Zhong, YM
   Xu, YY
   Tan, YZ
   Zhang, XX
   Wang, RL
   Chen, DM
   Wang, ZT
   Zhong, XL
AF Zhong, Yanmei
   Xu, Yingying
   Tan, Yongzhen
   Zhang, Xuanxuan
   Wang, Ruolun
   Chen, Danmin
   Wang, Zhaotao
   Zhong, Xunlong
TI Lipidomics of the erythrocyte membrane and network pharmacology to
   explore the mechanism of mangiferin from Anemarrhenae
   rhizoma in treating type 2 diabetes mellitus rats
SO JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
LA English
DT Article
DE Mangiferin; Type 2 diabetes mellitus; Erythrocyte membrane; Lipidomics;
   Network pharmacology; Molecular docking
ID ACTIVATION; INFLAMMASOME; STRESS; RISK; ACID
AB Mangiferin, a natural C-glucoside xanthone, is one of the major bioactive ingredients derived from the dry rhizome of Anemarrhenae rhizome, which has been reported to exhibit various pharmacological effects, including anti-oxidant, anti-inflammatory, anti-fatty liver, anti-metabolic syndrome, and anti-diabetic. However, the precise molecular mechanisms underlying its impact on phospholipid metabolism in the erythrocyte membrane of type 2 diabetes mellitus (T2DM) remain unclear. The present research aimed to evaluate the effects of mangiferin on glucose and lipid metabolism in T2DM model rats and discuss the relationship between lipid metabolites and potential targets involved in the hypoglycemic effects by integrating lipidomics and network pharmacology method. After 8 consecutive weeks of treatment with mangiferin, the T2DM model rats exhibited significant improvements in several biochemical indices and cytokines, including fasting blood glucose (FBG) levels after 12 h of fasting, fasting insulin level (FINS), total cholesterol (T-CHO), triacylglycerols (TG), highdensity lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), homeostasis model assessment of insulin resistance (HMOA-IR), TNF-& alpha; and IL-6. A total of 22 differential lipid metabolites were selected from erythrocyte membrane phospholipids, which were closely associated with the processes of T2DM. These metabolites mainly belonged to glycerophospholipid metabolism and sphingolipid metabolism. Based on network pharmacology analysis, 22 genes were recognized as the potential targets of mangiferin against diabetes. Moreover, molecular docking analysis revealed that the targets of TNF, CASP3, PTGS2, MMP9, RELA, PLA2G2A, PPARA, and NOS3 could be involved in the modulation of inflammatory signaling pathways and arachidonic acid (AA) metabolism to improve IR and hyperglycemia. The combination of immunohistochemical staining and PCR showed that mangiferin could treat T2DM by regulating the expression of PPAR & gamma; protein and NF-& kappa;B mRNA expression to impact glycerophospholipids (GPs) and AA metabolism. The present study showed that mangiferin might alleviate IR and hyperglycemia of T2DM model rats via multiple targets and multiple
C1 [Zhong, Yanmei; Zhang, Xuanxuan] Guangdong Pharmaceut Univ, Ctr Drug Res & Dev, 280 Waihuan East Rd, Guangzhou 510006, Peoples R China.
   [Xu, Yingying; Wang, Ruolun; Zhong, Xunlong] Guangzhou Med Univ, Affiliated Hosp 2, Dept Pharm, 250 Changgang East Rd, Guangzhou 510260, Peoples R China.
   [Tan, Yongzhen] Guangzhou Med Univ, Affiliated Hosp 2, Dept Tradit Chinese Med, 250 Changgang East Rd, Guangzhou 510260, Peoples R China.
   [Chen, Danmin; Wang, Zhaotao] Guangzhou Med Univ, Affiliated Hosp 2, Inst Neurosci, Dept Neurosurg, 250 Changgang East Rd, Guangzhou 510260, Peoples R China.
C3 Guangdong Pharmaceutical University; Guangzhou Medical University;
   Guangzhou Medical University; Guangzhou Medical University
RP Zhong, XL (corresponding author), Guangzhou Med Univ, Affiliated Hosp 2, Dept Pharm, 250 Changgang East Rd, Guangzhou 510260, Peoples R China.; Wang, ZT (corresponding author), Guangzhou Med Univ, Affiliated Hosp 2, Inst Neurosci, Dept Neurosurg, 250 Changgang East Rd, Guangzhou 510260, Peoples R China.
EM wangzhaotao@gzhmu.edu.cn; gzzxls0923@163.com
RI wang, zhaotao/JVZ-9660-2024
FU National Natural Science Foundation of China [2019A1515010926]; Natural
   Science Foundation of Guangdong Province [20221242]; Projects of
   Traditional Chinese Medicine Bureau of Guangdong Province [YXKY202201];
   Special Fund for Hospital Pharmaceutical Research of Guangdong Province
   Hospital Association [A2023420]; Medical Scientific Research Foundation
   of Guang-dong Province [20222A011017]; Project of Traditional Chinese
   Medicine and Pharmacology of Guangzhou Municipal Health Commission; 
   [81901117]
FX This work was supported by the National Natural Science Foundation of
   China (grant number 81901117) , the Natural Science Foundation of
   Guangdong Province (grant number 2019A1515010926) , the Projects of
   Traditional Chinese Medicine Bureau of Guangdong Province (grant number
   20221242) , the Special Fund for Hospital Pharmaceutical Research of
   Guangdong Province Hospital Association (grant number YXKY202201) , the
   Medical Scientific Research Foundation of Guang-dong Province (grant
   number A2023420) , and the Project of Traditional Chinese Medicine and
   Pharmacology of Guangzhou Municipal Health Commission (grant number
   20222A011017) .
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NR 35
TC 9
Z9 9
U1 6
U2 27
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0731-7085
EI 1873-264X
J9 J PHARMACEUT BIOMED
JI J. Pharm. Biomed. Anal.
PD JUN 15
PY 2023
VL 230
AR 115386
DI 10.1016/j.jpba.2023.115386
EA APR 2023
PG 13
WC Chemistry, Analytical; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Pharmacology & Pharmacy
GA Q0AY0
UT WOS:001054231800001
PM 37044004
DA 2025-06-11
ER

PT J
AU Zhang, F
   Huai, RT
   Jia, FJ
   Cui, YX
   Wang, H
   Shen, XL
AF Zhang, Fan
   Huai, Ruituo
   Jia, Fengju
   Cui, Yixin
   Wang, Hao
   Shen, Xiaoli
TI Association between mixed dietary B vitamin intake and insulin
   resistance in US middle-aged and older adults without diabetes: The
   Bayesian kernel machine regression approach
SO ASIA PACIFIC JOURNAL OF CLINICAL NUTRITION
LA English
DT Article
DE dietary B vitamin intake; insulin resistance; joint effect;
   cross-sectional study; Bayesian Kernel Machine Regression (BKMR)
ID OXIDATIVE STRESS; HOMOCYSTEINE LEVELS; METABOLIC SYNDROME; FOLATE;
   HYPERHOMOCYSTEINEMIA; DEFICIENCY; BENZOPHENONE-3; HYPERGLYCEMIA;
   INFLAMMATION; RIBOFLAVIN
AB Background and Objectives: In daily life, the intake of dietary nutrients is mixed. However, evidence for the as-sociation between mixed dietary B vitamin intake and insulin resistance is limited. In this study, we estimated the joint effect of intake of various dietary B vitamins on insulin resistance. Methods and Study Design: This cross-sectional study used data from the National Health and Nutrition Examination Survey 2011-2018. We included 1,628 middle-aged and 1,058 older adults without diabetes. Multivariable logistic regression and Bayesian kernel machine regression models were constructed. Results: In the multivariable logistic regression, when all B vita-mins were included in the model, the ORs (95% CIs) of insulin resistance were 3.06 (1.00-9.37) and 0.42 (0.19-0.93) for the highest quartile of vitamin B-1 and B-12 intake in the middle-aged group when the lowest quartile was the reference. In the older group, no significant association was observed. In the Bayesian kernel machine re-gression analysis, a negative trend was noted between mixed B vitamin intake and insulin resistance in both ex-amined groups. The univariate exposure-response function indicated that vitamin B-12 intake was negatively as-sociated with insulin resistance in the middle-aged group, and that vitamin B-6 and dietary folate equivalent in-takes were negatively associated with insulin resistance in older group. The bivariate exposure-response function indicated a potential interaction effect between dietary intake of vitamin B-12 and those of vitamin B-1, B-2, nia-cin, and dietary folate equivalent on insulin resistance in older people. Conclusions: Our results suggest that mixed dietary B vitamin intake tends to decrease the OR of insulin resistance both in middle-aged and older peo-ple.
C1 [Zhang, Fan; Cui, Yixin; Wang, Hao; Shen, Xiaoli] Qingdao Univ, Sch Publ Hlth, Dept Epidemiol & Hlth Stat, Qingdao, Peoples R China.
   [Huai, Ruituo] Shandong Univ Sci & Technol, Dept Key Lab Robot & Intelligent Technol Shandong, Qingdao, Peoples R China.
   [Jia, Fengju] Qingdao Univ, Dept Sch Nursing, Qingdao, Peoples R China.
   [Shen, Xiaoli] Qingdao Univ, Dept Epidmiol & Hlth Stat, Med Coll, 308 Ningxia Rd, Qingdao 266071, Peoples R China.
C3 Qingdao University; Shandong University of Science & Technology; Qingdao
   University; Qingdao University
RP Shen, XL (corresponding author), Qingdao Univ, Dept Epidmiol & Hlth Stat, Med Coll, 308 Ningxia Rd, Qingdao 266071, Peoples R China.
EM shenxiaoli@qdu.edu.cn
RI Cui, Yixin/AAH-8561-2021
OI Cui, Yixin/0000-0001-8785-9608
FU National Natural Science Foundation of China [82171570]; Key Laboratory
   for Robot & Intelligent Technology of Shandong Province (Shan-dong
   University of Science and Technology, Qingdao) [266590]
FX The study was supported by the National Natural Science Foundation of
   China (82171570) and the Key Laboratory for Robot & Intelligent
   Technology of Shandong Province (Shan-dong University of Science and
   Technology, Qingdao 266590, China) .
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NR 66
TC 2
Z9 2
U1 1
U2 8
PU H E C PRESS, HEALTHY EATING CLUB PTY LTD
PI MCKINNON
PA PO BOX 4121, MCKINNON, VIC 3204, AUSTRALIA
SN 0964-7058
EI 1440-6047
J9 ASIA PAC J CLIN NUTR
JI Asia Pac. J. Clin. Nutr.
PD DEC
PY 2022
VL 31
IS 4
BP 768
EP 779
DI 10.6133/apjcn.202212_31(4).0019
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA A6YL7
UT WOS:000956556600019
PM 36576294
DA 2025-06-11
ER

PT J
AU Etzel, TM
   Braun, JM
   Kuiper, JR
   Calafat, AM
   Cecil, KM
   Chen, AM
   Lanphear, BP
   Yolton, K
   Kalkwarf, HJ
   Buckley, JP
AF Etzel, Taylor M.
   Braun, Joseph M.
   Kuiper, Jordan R.
   Calafat, Antonia M.
   Cecil, Kim M.
   Chen, Aimin
   Lanphear, Bruce P.
   Yolton, Kimberly
   Kalkwarf, Heidi J.
   Buckley, Jessie P.
TI Gestational and childhood phthalate exposures and adolescent body
   composition: The HOME study
SO ENVIRONMENTAL RESEARCH
LA English
DT Article
DE Phthalates; Prenatal exposures; Childhood exposures; Environmental
   epidemiology; Fat mass; Adolescent health
ID X-RAY ABSORPTIOMETRY; ADIPOSE-TISSUE DISTRIBUTION; BISPHENOL-A EXPOSURE;
   METABOLIC SYNDROME; CARDIOVASCULAR-DISEASE; IN-UTERO; ENVIRONMENTAL
   CHEMICALS; DIETHYLHEXYL PHTHALATE; OXIDATIVE STRESS; FOLLOW-UP
AB Background: Early life phthalate exposures may disrupt metabolism but results from human studies are inconsistent and few have examined body composition during adolescence. We investigated associations of gestational and childhood urinary phthalate biomarker concentrations with body composition at age 12 years.
   Methods: We used data from 206 mother-child pairs in a prospective pregnancy and birth cohort enrolled in Cincinnati, OH from 2003 to 2006. We measured nine phthalate metabolites in spot urine samples collected twice from mothers during pregnancy and up to seven times from children at 1, 2, 3, 4, 5, 8, and 12 years. At age 12 years, we assessed fat and lean mass of the whole body and android and gynoid subregions, and visceral fat area with dual x-ray absorptiometry, and calculated android to gynoid %fat ratio and age- and sex-standardized fat and lean mass index z-scores. Using a multiple informant model, we estimated covariate-adjusted associations between urinary phthalate biomarker concentrations at each time period and outcomes at age 12 years. We assessed effect measure modification by child sex using stratified models.
   Results: Generally, urinary mono-benzyl phthalate (MBzP) concentrations were modestly associated with lower fat and lean mass. Each 10-fold increase in urinary MBzP concentrations during gestation and at ages 5 and 8 years was associated with a -0.34 (95%CI: 0.72, 0.05), -0.44 (95% CI: 0.83, 0.05), and -0.35 (95% CI: -0.71, 0.00) z-score difference in lean body mass index, respectively. Urinary monoethyl phthalate, mono-(3-carboxypropyl) phthalate, and summed di(2-ethylhexyl) phthalate metabolites were associated with greater lean mass at some exposure periods. Slightly weaker but similar patterns of association were found with other body composition measures; associations did not differ by child sex.
   Conclusion: While most associations were weak, exposure to certain phthalates during gestation and childhood may be associated with adolescent body composition, particularly lean mass.
C1 [Etzel, Taylor M.; Kuiper, Jordan R.; Buckley, Jessie P.] Johns Hopkins Bloomberg Sch Publ Hlth, 615 N Wolfe St, Baltimore, MD 21205 USA.
   [Braun, Joseph M.] Brown Univ, 121 S Main St, Providence, RI 02903 USA.
   [Calafat, Antonia M.] Ctr Dis Control & Prevent, Div Lab Sci, Natl Ctr Environm Hlth, 4770 Buford Highway NE, Atlanta, GA 30341 USA.
   [Cecil, Kim M.; Yolton, Kimberly; Kalkwarf, Heidi J.] Cincinnati Childrens Hosp Med Ctr, 3333 Burnet Ave, Cincinnati, OH 45229 USA.
   [Cecil, Kim M.; Yolton, Kimberly; Kalkwarf, Heidi J.] Univ Cincinnati, Coll Med, 3230 Eden Ave, Cincinnati, OH 45267 USA.
   [Chen, Aimin] Univ Penn, 3400 Civ Ctr Blvd, Philadelphia, PA 19104 USA.
   [Lanphear, Bruce P.] Simon Fraser Univ, 8888 Univ Dr, Burnaby, BC V5A 1S6, Canada.
C3 Johns Hopkins University; Johns Hopkins Bloomberg School of Public
   Health; Brown University; Centers for Disease Control & Prevention -
   USA; Cincinnati Children's Hospital Medical Center; University System of
   Ohio; University of Cincinnati; University of Pennsylvania; Simon Fraser
   University
RP Buckley, JP (corresponding author), Johns Hopkins Bloomberg Sch Publ Hlth, Dept Environm Hlth & Engn, 615 N Wolfe St,Room W7515, Baltimore, MD 21205 USA.
EM Tetzel2@jh.edu; joseph_braun_1@brown.edu; jkuiper1@jhmi.edu;
   aic7@cdc.gov; kim.cecil@cchmc.org; Aimin.Chen@pennmedicine.upenn.edu;
   bruce_lanphear@sfu.ca; Kimberly.Yolton@cchmc.org;
   Heidi.Kalkwarf@cchmc.org; jbuckl19@jhu.edu
RI Yunkunis, Kimberly/AAO-5605-2021; Kuiper, Jordan/HRO-7455-2023; Calafat,
   Antonia/GOP-1115-2022
OI Kuiper, Jordan/0000-0002-4285-1562; Kalkwarf, Heidi/0000-0001-9030-8401;
   Yolton, Kimberly/0000-0002-4458-0516; Cecil, Kim/0000-0001-8233-5485;
   Buckley, Jessie/0000-0001-7976-0157
FU National Institute of Environmental Health Sciences of the National
   Institutes of Health [T32ES00714, R01ES030078, R01ES025214, R01ES014575,
   R01ES020349, R01ES027224, P01ES011261]; National Institute of
   Environmental Health Sciences [P30ES006096] Funding Source: NIH RePORTER
FX This work was supported by grants from the National Institute of
   Environmental Health Sciences of the National Institutes of Health
   (T32ES00714, R01ES030078, R01ES025214, R01ES014575, R01ES020349,
   R01ES027224, P01ES011261) . The content is solely the responsibility of
   the authors and does not necessarily represent the official views of the
   National Institutes of Health. We are grateful to the HOME Study
   participants for the time they have given to the study.
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NR 74
TC 5
Z9 5
U1 1
U2 9
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0013-9351
EI 1096-0953
J9 ENVIRON RES
JI Environ. Res.
PD SEP
PY 2022
VL 212
AR 113320
DI 10.1016/j.envres.2022.113320
EA APR 2022
PN B
PG 8
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA 3T4LK
UT WOS:000840247600011
PM 35461845
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Han, MM
   Pandey, D
AF Han, Mingming
   Pandey, Deepesh
TI ZMPSTE24 Regulates SARS-CoV-2 Spike Protein-enhanced Expression of
   Endothelial PAI-1
SO AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
LA English
DT Article
DE PAI-1; human pulmonary microvascular endothelial cell; zinc
   metallopeptidase STE24; angiotensin-converting enzyme 2; coronavirus
   disease
ID PLASMINOGEN-ACTIVATOR INHIBITOR; CONVERTING ENZYME 2; RENIN-ANGIOTENSIN
   SYSTEM; CELL SENESCENCE; GENE-EXPRESSION; IMMUNE-RESPONSE; RECEPTOR MAS;
   IN-VIVO; PRELAMIN; INDUCTION
AB Endothelial dysfunction is implicated in the thrombotic events reported in patients with coronavirus disease (COVID-19), but the underlying molecular mechanisms are unknown. Circulating levels of the coagulation cascade activator PAI-1 are substantially higher in patients with COVID-19 with severe respiratory dysfunction than in patients with bacterial sepsis and acute respiratory distress syndrome. Indeed, the elevation of PAI-1 is recognized as an early marker of endothelial dysfunction. Here, we report that the rSARS-CoV-2-S1 (recombinant severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2] viral envelope spike) glycoprotein stimulated robust production of PAI-1 by human pulmonary microvascular endothelial cells (HPMECs). We examined the role of protein degradation in this SARS-CoV-2-S1 induction of PAI-1 and found that the proteasomal degradation inhibitor bortezomib inhibited SARS-CoV-2-S1-mediated changes in PAI-1. Our data further show that bortezomib upregulated KLF2, a shear-stress-regulated transcription factor that suppresses PAI-1 expression. Aging and metabolic disorders are known to increase mortality and morbidity in patients with COVID-19. We therefore examined the role of ZMPSTE24 (zinc metallopeptidase STE24), a metalloprotease with a demonstrated role in host defense against RNA viruses that is decreased in older individuals and in metabolic syndrome, in the induction of PAI-1 in HPMECs by SARS-CoV-2S1. Indeed, overexpression of ZMPSTE24 blunted enhancement of PAI-1 production in spike protein-exposed HPMECs. In addition, we found that membrane expression of the SARS-CoV-2 entry receptor ACE2 was reduced by ZMPSTE24-mediated cleavage and shedding of the ACE2 ectodomain, leading to accumulation of ACE2 decoy fragments that may bind SARS-CoV-2. These data indicate that decreases in ZMPSTE24 with age and comorbidities may increase vulnerability to vascular endothelial injury by SARS-CoV-2 viruses and that enhanced production of endothelial PAI-1 might play role in prothrombotic events in patients with COVID-19.
C1 [Han, Mingming; Pandey, Deepesh] Johns Hopkins Univ, Dept Anesthesiol & Crit Care Med, 1721 East Madison St,Ross Bldg,Room 345, Baltimore, MD 21205 USA.
   [Han, Mingming] Univ Sci & Technol, Affiliated Hosp 1, Dept Anesthesiol, Hefei, Anhui, Peoples R China.
   [Han, Mingming] Univ Sci & Technol China, Div Life Sci & Med, Hefei, Anhui, Peoples R China.
C3 Johns Hopkins University; Chinese Academy of Sciences; University of
   Science & Technology of China, CAS; Chinese Academy of Sciences;
   University of Science & Technology of China, CAS
RP Pandey, D (corresponding author), Johns Hopkins Univ, Dept Anesthesiol & Crit Care Med, 1721 East Madison St,Ross Bldg,Room 345, Baltimore, MD 21205 USA.
EM dpandey2@jhmi.edu
RI HAN, MINGMING/AAR-5381-2021
FU American Heart Association Scientist Development Grant; National
   Institutes of Health [R56 HL139736]; Department of Anesthesiology and
   Critical Care Medicine at Johns Hopkins University
FX Supported by an American Heart Association Scientist Development Grant
   and National Institutes of Health grant R56 HL139736 (D.P.). Dr. Sujatha
   Kannan, Vice Chair of Research, Department of Anesthesiology and
   Critical Care Medicine at Johns Hopkins University, provided research
   funds to support this study.
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NR 49
TC 26
Z9 26
U1 1
U2 12
PU AMER THORACIC SOC
PI NEW YORK
PA 25 BROADWAY, 18 FL, NEW YORK, NY 10004 USA
SN 1044-1549
EI 1535-4989
J9 AM J RESP CELL MOL
JI Am. J. Respir. Cell Mol. Biol.
PD SEP
PY 2021
VL 65
IS 3
BP 300
EP 308
DI 10.1165/rcmb.2020-0544OC
PG 9
WC Biochemistry & Molecular Biology; Cell Biology; Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology; Respiratory System
GA UL5IM
UT WOS:000692684500011
PM 34003736
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Foucaut, AM
   Faure, C
   Julia, C
   Czernichow, S
   Levy, R
   Dupont, C
   Aknin, I
   Cedrin-Durnerin, I
   Cens, S
   Chavatte-Palmer, P
   Hercberg, S
   Pocate, K
   Sermondade, N
   Uthurriague, C
   Wolf, JP
AF Foucaut, Aude-Marie
   Faure, Celine
   Julia, Chantal
   Czernichow, Sebastien
   Levy, Rachel
   Dupont, Charlotte
   Aknin, Isabelle
   Cedrin-Durnerin, Isabelle
   Cens, Steven
   Chavatte-Palmer, Pascale
   Hercberg, Serge
   Pocate, Khaled
   Sermondade, Nathalie
   Uthurriague, Claude
   Wolf, Jean-Philippe
CA ALIFERT Collaborative Grp
TI Sedentary behavior, physical inactivity and body composition in relation
   to idiopathic infertility among men and women
SO PLOS ONE
LA English
DT Article
ID SEMEN QUALITY DATA; MASS INDEX; METABOLIC SYNDROME; OXIDATIVE STRESS;
   VITAMIN-D; REPRODUCTIVE HORMONES; INSULIN-RESISTANCE; OBESITY; TIME;
   ASSOCIATION
AB Background
   Physical activity (PA) and sedentary behavior have inconsistent effects on fertility. High body mass index is associated with infertility but to our knowledge, very few studies have explored body composition in association to fertility.
   Objective
   To assess the association between physical inactivity, sedentary behavior, body composition and idiopathic infertility in French men and women.
   Design
   We conducted a case-control multicentric observational study. 159 infertile (79 men and 80 women) and 143 fertile (72 men and 71 women) were recorded in four fertility centers.
   Main outcome measures
   Participants completed self-administered questionnaires on sociodemographic and lifestyle characteristics, dietary intake, physical activity and sedentary behavior. Anthropometrics were measured, and bioelectrical impedance analysis was used to estimate body composition. Multivariable logistic regression was used to analyze the association of fertility with PA level and sedentary behavior.
   Results
   In men, being physically inactive (Odd ratio [OR] 2.20; 95% confidence interval [CI], 1.06, 4.58) and having fat mass greater than the reference values for their age (OR 2.83; 95% CI, 1.31, 6.10) were positively associated with infertility. Sedentary behavior and fat-free mass were not related to infertility in men. In women, sedentary behavior (OR 3.61; 95% CI, 1.58, 8.24), high body fat (OR 3.16; 95% CI, 1.36, 7.37) and low fat-free mass (OR 2.65; 95% CI, 1.10, 6.37) were associated with infertility. PA level was not associated with fertility in women.
   Conclusions
   This study suggests that sedentary behavior and physical inactivity would represent two independent risk factors associated with infertility. The various elements that make up physical activity (frequency, intensity, time, and type of exercise) and the interrupting time spent sitting should be considered. Body composition variation should be explored further in relation to the biological pathways involved in idiopathic infertility. Moreover, the improvement of lifestyle factors should be considered in infertility treatment.
C1 [Foucaut, Aude-Marie] Univ Paris 13, Sorbonne Paris Cite, UFR SMBH, LEPS,EA 3412, Bobigny, France.
   [Faure, Celine; Sermondade, Nathalie] Hop Tenon, AP HP, Serv Biol Reprod, CECOS, Paris, France.
   [Julia, Chantal] Univ Paris 13, Ctr Epidemiol & Biostat, Sorbonne Paris Cite CRESS,EREN, Inserm U1153,Inra U1125,Cnam,COMUE Sorbonne Paris, Bobigny, France.
   [Julia, Chantal] Hop Avicenne, AP HP, Dept Sante Publ, Bobigny, France.
   [Czernichow, Sebastien] Hop Europeen Georges Pompidou, AP HP, Serv Nutr, Ctr Specialise Obesite IdF, Paris, France.
   [Czernichow, Sebastien] Univ Paris 05, Paris, France.
   [Levy, Rachel; Dupont, Charlotte] Sorbonne Univ, Hop Tenon, AP HP,Serv Biol Reprod CECOS, St Antoine Res Ctr,INSERM,Equipe Lipodystrophies, Paris, France.
   [Aknin, Isabelle] Hop Nord St Etienne, Unite Fonct Biol Reprod, Histol Embryol Cytogenet, St Etienne, France.
   [Cedrin-Durnerin, Isabelle] Hop Jean Verdier, AP HP, Serv Med Reprod, Bondy, France.
   [Cens, Steven; Uthurriague, Claude] PAU, Ctr AMP, Polyclin Navarre, Pau, France.
   [Chavatte-Palmer, Pascale] INRA, UMR1198, Biol Dev & Reprod, Jouy En Josas, France.
   [Hercberg, Serge] Univ Paris 13, CRNH IdF, INSERM, INRA,CNAM,EREN,U557, F-93017 Bobigny, France.
   [Pocate, Khaled; Wolf, Jean-Philippe] Hop Cochin, AP HP, Serv Histol Embryol Biol Reprod, Paris, France.
C3 Universite Paris 13; Assistance Publique Hopitaux Paris (APHP); Sorbonne
   Universite; Hopital Universitaire Tenon - APHP; Universite Paris Cite;
   heSam Universite; Conservatoire National Arts & Metiers (CNAM); INRAE;
   Universite Paris 13; Institut National de la Sante et de la Recherche
   Medicale (Inserm); Assistance Publique Hopitaux Paris (APHP); Hopital
   Universitaire Avicenne - APHP; Universite Paris 13; Assistance Publique
   Hopitaux Paris (APHP); Universite Paris Cite; Hopital Universitaire
   Europeen Georges-Pompidou - APHP; Universite Paris Cite; Assistance
   Publique Hopitaux Paris (APHP); Sorbonne Universite; Hopital
   Universitaire Saint-Antoine - APHP; Hopital Universitaire Tenon - APHP;
   Institut National de la Sante et de la Recherche Medicale (Inserm); CHU
   de St Etienne; Assistance Publique Hopitaux Paris (APHP); Hopital
   Universitaire Jean-Verdier - APHP; Universite Paris Saclay; INRAE;
   Universite Paris 13; heSam Universite; Conservatoire National Arts &
   Metiers (CNAM); INRAE; Institut National de la Sante et de la Recherche
   Medicale (Inserm); Assistance Publique Hopitaux Paris (APHP); Universite
   Paris Cite; Hopital Universitaire Cochin - APHP
RP Foucaut, AM (corresponding author), Univ Paris 13, Sorbonne Paris Cite, UFR SMBH, LEPS,EA 3412, Bobigny, France.
EM audemarie.foucaut@univ-paris13.fr
RI Dupont, Charlotte/AAL-8780-2020; Serge, Hercberg/F-3038-2017; Chantal,
   Julia/F-2805-2017; Sermondade, Nathalie/NEU-1253-2025; Chavatte-Palmer,
   Pascale/K-7349-2012
OI Foucaut, Aude-Marie/0000-0002-4258-1355; Chavatte-Palmer,
   Pascale/0000-0002-4581-6092; Julia, Chantal/0000-0003-2006-5269
FU  [P071224 ALIFERT]
FX This study was supported by national biomedical research P071224
   ALIFERT. The funder had no role in study design, data collection and
   analysis, decision to publish, or preparation of the manuscript.
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NR 85
TC 54
Z9 55
U1 0
U2 28
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD APR 24
PY 2019
VL 14
IS 4
AR e0210770
DI 10.1371/journal.pone.0210770
PG 15
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA HU6FU
UT WOS:000465375400005
PM 31017887
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU da Silva, AI
   Braz, GRF
   Silva, SCD
   Pedroza, AAD
   de Lima, NC
   Silva, TLD
   Lagranha, CJ
AF da Silva, Aline Isabel
   Braz, Glauber Ruda F.
   Silva, Severina Cassia de A.
   Pedroza, Anderson Apolonio da S.
   de Lima-Junior, Nelson Correia
   Silva, Tercya Lucidi de A.
   Lagranha, Claudia Jacques
TI Body composition, biochemical, behavioral and molecular alterations in
   overfed rats after chronic exposure to SSRI
SO BEHAVIOURAL BRAIN RESEARCH
LA English
DT Article
DE Overfeeding; Serotonin; Selective serotonin reuptake inhibitors (SSRIs);
   Food behavior; Energy balance; Hypothalamus
ID FLUOXETINE TREATMENT; FOOD-INTAKE; GENE-EXPRESSION; ADIPOSE-TISSUE;
   GLUCOSE-HOMEOSTASIS; METABOLIC SYNDROME; OXIDATIVE STRESS; RECEPTOR
   AGONIST; NEUROPEPTIDE-Y; 2C RECEPTORS
AB Serotonin (5-HT) plays a regulatory role in coordinating the neural circuits regulating energy balance, with differences in both 5-HT availability at the synapse and the activity of 5-HT receptors mediating anorectic (via POMC/CART activation) and orexigenic (via NPY/AgRP activation) responses. In conditions of overweight and obesity the control of energy balance is clearly deregulated, and serotonergic modulation appears to make a significant contribution to weight gain. Fluoxetine (FLX), a selective serotonin reuptake inhibitor (SSRI) that increases 5-HT availability in the synaptic cleft may thus have potential effects on energy balance. Our aim was to use an overfeeding model to investigate the effects of chronic FLX treatment on energy balance-related parameters regulated by hypothalamic neuropeptides. Nursing male Wistar rats were assigned to normofed (9 pups/dam) or overfed (3 pups/dam) groups beginning at 3 days of age and continuing until 21 days of age, when commercial chow and water were made available ad libitum until experimental treatments were begun. From 39 through 59 days of age groups were divided according to pharmacological treatment: 1) NV group, normofed + vehicle solution (NaCl 0.9%, 10 ml/kg b.w.), 2) NF group, normofed + FLX (10 mg/kg b.w., in vehicle solution, 10 ml/kg b.w.) 3), OV, overfed + vehicle solution and 4) OF, overfed + FLX. At 60 days of age, body weight, white and brown adipose tissue content, and food intake were determined, and serum biochemical parameters and hypothalamic neuropeptide gene expression were measured. Results showed that FLX induced reductions in several murinometric indices, improvement of adipose profile, hypophagic behavior, reduction in serum parameters, and positive modulation of hypophagia-related genes. These data suggest that the beneficial effects of FLX-treatment on overfeeding-induced physical and behavioral effects in rats was due to hypothalamic alterations that led to improvement in energy balance in animals with a compromised metabolism.
C1 [da Silva, Aline Isabel; Braz, Glauber Ruda F.; Silva, Tercya Lucidi de A.; Lagranha, Claudia Jacques] Univ Fed Pernambuco UFPE, Neuropsychiat & Behav Sci Grad Program, Recife, PE, Brazil.
   [da Silva, Aline Isabel; Braz, Glauber Ruda F.; Silva, Severina Cassia de A.; Pedroza, Anderson Apolonio da S.; de Lima-Junior, Nelson Correia; Silva, Tercya Lucidi de A.; Lagranha, Claudia Jacques] Univ Fed Pernambuco UFPE, Acad Ctr Vitoria CAV, Dept Phys Educ & Sports Sci, Lab Biochem & Exercise Biochem, Vitoria De Santo Antao, PE, Brazil.
C3 Universidade Federal de Pernambuco; Universidade Federal de Pernambuco
RP Lagranha, CJ (corresponding author), Nucleo Educ Fis & Ciencias Esporte UFPE CAV, Rua Alto Reservatorio S-N, BR-55608680 Vitoria De Santo Antao, PE, Brazil.
EM claudia.lagranha@ufpe.br
RI Braz, Glauber/D-4811-2016
OI Feitoza Braz, Glauber Ruda/0000-0001-6107-5047; da Silva, Aline
   Isabel/0009-0005-1102-6155; PEDROZA, ANDERSON/0000-0002-6136-6677;
   Lagranha, Claudia/0000-0001-6883-9476
FU FACEPE (Foundation for the Support of Science and Research from
   Pernambuco State, Brazil); CAPES (Brazilian Federal Agency for Support
   and Evaluation of Graduate Education within the Ministry of Education of
   Brazil); CNPq; FACEPE
FX The authors are thankful to Dr Donald F Sellitti, for collaborating in
   the editing of this manuscript for publication in English. The authors
   are grateful to Dr Sandra Lopes de Souza for the technical support with
   PCR experiments and comments that helped paper's discussion. The authors
   also appreciate funding provided by FACEPE (Foundation for the Support
   of Science and Research from Pernambuco State, Brazil) to acquirement of
   equipment and reagents used in this work, and to CAPES (Brazilian
   Federal Agency for Support and Evaluation of Graduate Education within
   the Ministry of Education of Brazil); CNPq and FACEPE that provided
   scholarships.
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NR 56
TC 19
Z9 19
U1 0
U2 15
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0166-4328
EI 1872-7549
J9 BEHAV BRAIN RES
JI Behav. Brain Res.
PD JAN 1
PY 2019
VL 356
BP 62
EP 70
DI 10.1016/j.bbr.2018.08.007
PG 9
WC Behavioral Sciences; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Behavioral Sciences; Neurosciences & Neurology
GA HA0JR
UT WOS:000449894800007
PM 30099029
DA 2025-06-11
ER

PT J
AU Almaida-Pagán, PF
   Ortega-Sabater, C
   Lucas-Sánchez, A
   Martinez-Nicolas, A
   Espinosa, C
   Esteban, MA
   Madrid, JA
   Rol, M
   Mendiola, P
   de Costa, J
AF Almaida-Pagan, P. F.
   Ortega-Sabater, C.
   Lucas-Sanchez, A.
   Martinez-Nicolas, A.
   Espinosa, C.
   Esteban, M. A.
   Madrid, J. A.
   Rol, M.
   Mendiola, P.
   de Costa, J.
TI Impact of a shift work-like lighting schedule on the functioning of the
   circadian system in the short-lived fish Nothobranchius furzeri
SO EXPERIMENTAL GERONTOLOGY
LA English
DT Article
DE Circadian rhythm; Chronodisruption; Nothobranchius; Shift-work;
   Molecular clock
ID SKIN MUCUS; SUPRACHIASMATIC NUCLEUS; METABOLIC SYNDROME; ACTIVITY
   RHYTHMS; GENE-EXPRESSION; OCTODON-DEGUS; SPARUS-AURATA; JET-LAG;
   MELATONIN; HEALTH
AB Adult Nothobranchius furzeri of the MZM-04/10 strain were individually kept and subjected to a "5 + 2" shifting lighting schedule (SHIFT) for 8 weeks in order to evaluate the desynchronizing effects of a simulated human-like shift-work schedule on the functioning of the circadian system (CS). With this aim, sixteen 21-week-old N. furzeri were placed into a Morning, Night and Evening schedule (lights on from 08: 00 to 16: 00, 00: 00 to 08: 00 and 16: 00 to 00: 00 h, respectively) and fed once a day in the middle of the corresponding photophase (12: 00, 04: 00 and 20: 00 h, respectively). Then, in the weekends (2 days), fish were always returned to the Morning shift. As controls, 16 fish were maintained under a non-shifting LD cycle condition (CONTROL) throughout the whole experiment, with lights on from 08: 00 to 16: 00 h.
   Rest-activity rhythm (RAR) of fish subjected to SHIFT showed several symptoms of chronodisruption, such as a decrease in the percentage of diurnal activity and a reduction of the relative amplitude and the circadian function index with time. When a periodogram analysis was performed, RAR of N. furzeri under SHIFT conditions showed up to three separate circadian components: one longer than 24 h (26.5 h) that followed the weekly 8 h delays; a short-period component (similar to 23 h) that was related to the weekend's phase advances, and finally, a 24 h component.
   The shifting LD schedule also affected fish CS at a molecular level, with several significant differences in the expression of core genes of the molecular clock (bmal1, clock, rora, rev-erba) between SHIFT and CONTROL animals. RAR impairment along with changes in clock gene expression could be associated with high stress and accelerated aging in these fish.
C1 [Almaida-Pagan, P. F.; Ortega-Sabater, C.; Lucas-Sanchez, A.; Martinez-Nicolas, A.; Madrid, J. A.; Rol, M.; Mendiola, P.; de Costa, J.] Univ Murcia, Dept Physiol, Coll Biol, Chronobiol Lab,IUIE,IMIB Arrixaca, Mare Nostrum Campus, Murcia, Spain.
   [Almaida-Pagan, P. F.; Ortega-Sabater, C.; Lucas-Sanchez, A.; Martinez-Nicolas, A.; Madrid, J. A.; Rol, M.; Mendiola, P.; de Costa, J.] CIBERFES, Madrid, Spain.
   [Espinosa, C.; Esteban, M. A.] Univ Murcia, Fish Innate Immune Syst Grp, Dept Cell Biol & Histol, Coll Biol, Mare Nostrum Campus, Murcia, Spain.
C3 University of Murcia; Hospital Clinico Universitario Virgen de la
   Arrixaca; CIBER - Centro de Investigacion Biomedica en Red; CIBERFES;
   University of Murcia
RP Almaida-Pagán, PF (corresponding author), Univ Murcia, Dept Physiol, Coll Biol, Chronobiol Lab,IUIE,IMIB Arrixaca, Mare Nostrum Campus, Murcia, Spain.
EM pfalmaida@um.es
RI madrid, juan/K-5322-2017; Lucas-Sánchez, Alejandro/H-1232-2015; ROL,
   ANGELES/ABH-6431-2020; Esteban, María/D-6709-2011; Martinez-Nicolas,
   Antonio/A-7560-2012; ORTEGA, CARMEN/ABC-8616-2021; Espinosa Ruiz,
   Cristobal/C-2555-2019; Almaida-Pagan, Pedro F/A-9190-2019; ROL,
   ANGELES/C-6718-2009
OI Esteban, Maria Angeles/0000-0002-6264-1458; Espinosa Ruiz,
   Cristobal/0000-0002-3063-1634; Almaida-Pagan, Pedro
   F/0000-0003-1965-3813; ROL, ANGELES/0000-0002-9343-3918
FU Fundacion ONCE, "Oportunidad al Talento" Programme (ESF); Ministry of
   Economy and Competitiveness; Instituto de Salud Carlos III through the
   RETICEF Network (The Aging and Frailty Cooperative Research Network)
   [RD12/0043/0011]; CIBERFES grant [CB16/10/00239]; FEDER [19899/GERM/15]
FX P.F.A.-P. was funded by a research grant from the Fundacion ONCE, as
   part of the "Oportunidad al Talento" Programme (co-financed by ESF).
   This work was supported by the Ministry of Economy and Competitiveness,
   the Instituto de Salud Carlos III through the RETICEF Network (The Aging
   and Frailty Cooperative Research Network, RD12/0043/0011), a CIBERFES
   grant (CB16/10/00239) and a grant 19899/GERM/15 awarded to JAM
   (co-financed by FEDER). We would like to thank Imanol Martinez for his
   kind revision of the manuscript.
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NR 65
TC 6
Z9 7
U1 1
U2 11
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0531-5565
EI 1873-6815
J9 EXP GERONTOL
JI Exp. Gerontol.
PD OCT 2
PY 2018
VL 112
BP 44
EP 53
DI 10.1016/j.exger.2018.08.010
PG 10
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA GV2HS
UT WOS:000445909300006
PM 30184464
DA 2025-06-11
ER

PT J
AU Kim, SY
   Kim, SG
   Sim, S
   Park, B
   Choi, HG
AF Kim, So Young
   Kim, Sung-Gyun
   Sim, Songyong
   Park, Bumjung
   Choi, Hyo Geun
TI Excessive Sleep and Lack of Sleep Are Associated With Slips and Falls in
   the Adult Korean Population A Population-Based Cross-Sectional Study
SO MEDICINE
LA English
DT Article
ID NUTRITION EXAMINATION SURVEY; COMMUNITY-HEALTH SURVEY; MENOPAUSAL
   TRANSITION; METABOLIC SYNDROME; NATIONAL-HEALTH; RISK-FACTOR; DURATION;
   DEPRIVATION; AGE; WOMEN
AB Few studies have evaluated the impacts of excessive sleep duration on falls. This study investigated the associations between sleep duration and falls among Korean adults in a wide range of age groups while adjusting for numerous confounding factors. Data collected from study participants ranging in age from 19 to 109 years old were analyzed from the 2013 Korean Community Health Survey (KCHS). Sleep duration was divided into 5 groups: <= 5, 6, 7, 8, and >= 9 hours per day. The relations between sleep duration and falls (>= 1 time or >= 2 times per year) were analyzed using simple and multiple logistic regression analyses with complex sampling. Age, sex, days of vigorous or moderate physical activity, income, education, alcohol use, smoking, stress, obesity, hypertension, diabetes mellitus, hyperlipidemia, stroke, angina or myocardial infarction, arthritis, and asthma were controlled for as confounding factors. Associations between sleep duration and falls were analyzed in 19 to 40, 41 to 60, and 61+ year age groups. Furthermore, the relations between sleep duration and indoor versus outdoor falls were analyzed. Both <= 6 and >= 8 hours of sleep per day were significantly associated with an increased incidence of falls (>= 1 time and >= 2 times per year) in the overall adult population (P < 0.001 in both instances). In a subgroup analysis, sleep durations of <= 5 and >= 9 hours were significantly associated with an increased incidence of falls (>= 1 time a year) in each age group. Six hours of sleep was not significantly associated with falls (>= 2 times per year) in the 61+ year age group, and 8 and 9 hours of sleep were not significantly associated with falls (>= 2 times a year) in the 19 to 40 year age group. This study demonstrated that long as well as short sleep durations are associated with an increased incidence of falls. However, these relations were not evident in elderly populations with short sleep durations or in young adults with long sleep durations.
C1 [Kim, So Young] Seoul Natl Univ, Coll Med, Dept Otorhinolaryngol Head & Neck Surg, Seoul, South Korea.
   [Kim, Sung-Gyun] Hallym Univ, Coll Med, Dept Internal Med, Anyang, South Korea.
   [Sim, Songyong] Hallym Univ, Dept Stat, Chunchon, South Korea.
   [Park, Bumjung; Choi, Hyo Geun] Hallym Univ, Sacred Heart Hosp, Dept Otorhinolaryngol Head & Neck Surg, Anyang, South Korea.
C3 Seoul National University (SNU); Hallym University; Hallym University;
   Hallym University
RP Choi, HG (corresponding author), Hallym Univ, Sacred Heart Hosp, Dept Otorhinolaryngol Head & Neck Surg, 22 Gwanpyeong Ro 170Beon Gil, Anyang Si 431796, Gyeonggi Do, South Korea.
EM pupen@naver.com
RI Kim, Yong-Tae/HQZ-0240-2023; Kim, Soo-Yeon/ADR-9663-2022; Lee,
   Hyo-Jeong/AAK-7973-2020; Choi, Hyo/K-4461-2019
FU National Research Foundation (NRF) of Korea [NRF-2015R1D1A1A01060860]
FX This work was supported by the National Research Foundation (NRF) of
   Korea (NRF-2015R1D1A1A01060860).
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NR 32
TC 25
Z9 28
U1 0
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD JAN
PY 2016
VL 95
IS 4
AR e2397
DI 10.1097/MD.0000000000002397
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA DE3JG
UT WOS:000370524100001
PM 26825881
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Trpkovic, A
   Resanovic, I
   Stanimirovic, J
   Radak, D
   Mousa, SA
   Cenic-Milosevic, D
   Jevremovic, D
   Isenovic, ER
AF Trpkovic, Andreja
   Resanovic, Ivana
   Stanimirovic, Julijana
   Radak, Djordje
   Mousa, Shaker A.
   Cenic-Milosevic, Desanka
   Jevremovic, Danimir
   Isenovic, Esma R.
TI Oxidized low-density lipoprotein as a biomarker of cardiovascular
   diseases
SO CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES
LA English
DT Review
DE Atherogenesis; biomarker; cardiovascular risk assessment; lipoprotein
   (a); oxidized lipoproteins; statins
ID C-REACTIVE PROTEIN; INTIMA-MEDIA THICKNESS; CORONARY-HEART-DISEASE;
   HUMAN-ENDOTHELIAL-CELLS; VASCULAR SMOOTH-MUSCLE; SUBCLINICAL
   ATHEROSCLEROSIS DEVELOPMENT; TYPE-2 DIABETES-MELLITUS; OXIDATIVE STRESS
   MARKERS; LDL-INDUCED CYTOTOXICITY; BIOCHEMICAL RISK MARKER
AB Atherosclerosis is a life-long illness that begins with risk factors, which in turn contribute to the development of subclinical disease, followed by the establishment of overt cardiovascular disease (CVD). Thrombotic-occlusive complications of atherosclerosis are among the most widespread and costly health problems. Oxidized low-density lipoprotein (OxLDL) plays an important role in atherogenesis by promoting an inflammatory environment and lipid deposition in the arterial wall. As cardiovascular events occur in individuals without common risk factors, there is a need for additional tools that may help in CVD risk assessment and management. The use of biomarkers has improved diagnostic, therapeutic and prognostic outcome in cardiovascular medicine. This review elaborates on the value of circulating OxLDL as a biomarker of CVD. Three enzyme-linked immunosorbent assays (4E6, DLH3 and E06) using murine monoclonal antibodies for determination of OxLDL blood levels have been developed. However, none of these assays are currently approved for routine clinical practice. We identified studies investigating OxLDL in CVD (measured by 4E6, DLH3 or E06 assay) by searching the PubMed database. Circulating OxLDL was found to be associated with all stages of atherosclerosis, from early atherogenesis to hypertension, coronary and peripheral arterial disease, acute coronary syndromes and ischemic cerebral infarction. The results of studies investigating the usefulness of OxLDL for CVD prediction were also summarized. Furthermore, OxLDL was found to be associated with pathologic conditions linked to CVD, including diabetes mellitus, obesity and metabolic syndrome (MetS). In addition, we have addressed the mechanisms by which OxLDL promotes atherogenesis, and the effects of antiatherogenic treatments on circulating OxLDL. Finally, we highlight the evidence suggesting that lipoprotein (a) [ Lp(a)] is the preferential carrier of oxidized phospholipids (OxPL) in human plasma. A strong association between OxPLapoB level (representing the content of OxPL on apolipoprotein B-100 particles, measured by E06 assay) and Lp(a) has been determined.
C1 [Trpkovic, Andreja; Resanovic, Ivana; Stanimirovic, Julijana; Isenovic, Esma R.] Univ Belgrade, Vinca Inst Nucl Sci, Lab Radiobiol & Mol Genet, Belgrade 11000, Serbia.
   [Radak, Djordje] Univ Belgrade, Dedinje Cardiovasc Inst, Dept Vasc Surg, Belgrade 11000, Serbia.
   [Mousa, Shaker A.] Albany Coll Pharm & Hlth Sci, Pharmaceut Res Inst, Albany, NY USA.
   [Cenic-Milosevic, Desanka; Jevremovic, Danimir] Univ Business Acad Novi Sad, Fac Stomatol Pancevo, Novi Sad, Serbia.
C3 University of Belgrade; University of Belgrade; Albany College of
   Pharmacy & Health Sciences; University of Novi Sad
RP Isenovic, ER (corresponding author), Univ Belgrade, Vinca Inst Nucl Sci, Lab Radiobiol & Mol Genet, Mike Petrovica Alasa 12-14 St,POB 522, Belgrade 11000, Serbia.
EM isenovic@yahoo.com
RI Isenovic, Esma/D-3017-2009; Stanimirovic, Julijana/LPQ-7867-2024; Mousa,
   Shaker/A-7151-2017
OI Isenovic, Esma/0000-0002-0012-2636; Mousa, Shaker/0000-0002-9294-015X;
   Stanimirovic, Julijana/0000-0002-0929-3482; Resanovic,
   Ivana/0000-0003-2742-7912
FU Ministry of Education and Science, Republic of Serbia [173033, 41002]
FX The Authors declare that there is no conflict of interest. This work was
   supported by grants funded by the Ministry of Education and Science,
   Republic of Serbia, No. 173033 (to E. R. I.) and No. 41002 (to Dj. R.).
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PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1040-8363
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J9 CRIT REV CL LAB SCI
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DA 2025-06-11
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PT J
AU Yang, H
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   Chen, A
   Adelson, DW
   Smutko, V
   Wijesuriya, J
   Go, VLW
   Tuck, ML
AF Yang, Hong
   Nyby, Michael D.
   Ao, Yan
   Chen, Ai
   Adelson, David W.
   Smutko, Victoria
   Wijesuriya, Janake
   Go, Vay Liang W.
   Tuck, Michael L.
TI Role of brainstem thyrotropin-releasing hormone-triggered sympathetic
   overactivation in cardiovascular mortality in type 2 diabetic
   Goto-Kakizaki rats
SO HYPERTENSION RESEARCH
LA English
DT Article
DE brainstem; cardiovascular mortality; sympathetic nerve;
   thyrotropin-releasing hormone; type 2 diabetes
ID ROSTRAL VENTROLATERAL MEDULLA; DORSAL VAGAL COMPLEX; GENE-EXPRESSION;
   HEART-FAILURE; TRH ANALOG; METABOLIC SYNDROME; THYROID-HORMONE;
   NERVOUS-SYSTEM; CONSCIOUS RATS; BLOOD-PRESSURE
AB Sympathetic hyperactivity has an important role in cardiovascular mortality in patients with type 2 diabetes (T2D). Thyrotropin-releasing hormone (TRH)-containing fibers innervate autonomic motor and premotor nuclei of the brainstem and spinal cord that regulate cardiovascular functions. We compared cardiovascular responses to application of TRH-analog in the brainstem of Wistar and T2D Goto-Kakizaki (GK) rats. GK rats exhibited basal systolic hypertension (152 +/- 2 mm Hg) and had a significantly potentiated, dose-related hypertensive response to intracisternal (i.c.) injection of the TRH-analog RX77368 (10-60 ng). In GK rats only, i.c. RX77368 (30-60 ng) markedly increased heart rate (HR; +88 b.p.m.) and induced acute cardiac mortality (100%), concurrent with extreme hyperglycemia (>26 mmol l(-1)), increased plasma H2O2 and 8-isoprostane, and enhanced heart expression of NADPH oxidase 4 and vascular cell adhesion molecule-1 mRNAs. GK rats also had elevated basal plasma epinephrine, higher adrenal gene expression of tyrosine hydroxylase and dopamine beta-hydroxylase (D beta H), and greater plasma catecholamine and adrenal DbH responses to i.c. TRH-analog, compared with Wistar rats. In GK rats, hexamethonium blocked i.c. RX77368-induced hypertensive and tachycardic responses, and reduced mortality by 86%, whereas phentolamine abolished the hypertensive response but enhanced tachycardia (+160 b.p.m.), and reduced mortality by 50%. The angiotensin II type 1 receptor antagonist irbesartan prevented i.c. RX77368-induced increases in blood pressure, HR and mortality. In conclusion, sympathetic overactivation triggered by brainstem TRH contributes to the mechanism of cardiovascular morbidity and mortality in T2D, which involves heightened cardiac inflammation and peripheral oxidative stress responses to sympathetic drive, and a mediating role of the renin-angiotensin system. Hypertension Research (2012) 35, 157-165; doi:10.1038/hr.2011.154; published online 8 September 2011
C1 [Yang, Hong; Nyby, Michael D.; Ao, Yan; Chen, Ai; Adelson, David W.; Go, Vay Liang W.; Tuck, Michael L.] Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USA.
   [Yang, Hong; Nyby, Michael D.; Ao, Yan; Chen, Ai; Adelson, David W.; Smutko, Victoria; Wijesuriya, Janake; Go, Vay Liang W.; Tuck, Michael L.] Great Los Angeles Hlth Care Syst, Dept Vet Affairs, Res & Dev, Los Angeles, CA USA.
C3 University of California System; University of California Los Angeles;
   University of California Los Angeles Medical Center; David Geffen School
   of Medicine at UCLA
RP Yang, H (corresponding author), CURE DDRC VA GLAHS, Dept Med, Bldg 115,Room 203,11301 Wilshire Blvd, Los Angeles, CA 90073 USA.
EM hoyang@ucla.edu
RI Yang, Hong/ABF-5410-2021
OI Adelson, David/0000-0002-4623-6030
FU Department of Veterans Affairs; National Institute of Diabetes and
   Digestive and Kidney Diseases [DK-41301]; American Heart Association
FX This work was supported by Department of Veterans Affairs Merit Award (H
   Yang), National Institute of Diabetes and Digestive and Kidney Diseases
   Grant DK-41301 (Center for Ulcer Research and Education Center grant
   Animal Core) and American Heart Association (M Tuck). We thank Dr Ke-Wei
   Zhao for his contribution on the manuscript preparation.
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NR 53
TC 4
Z9 5
U1 0
U2 3
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0916-9636
J9 HYPERTENS RES
JI Hypertens. Res.
PD FEB
PY 2012
VL 35
IS 2
BP 157
EP 165
DI 10.1038/hr.2011.154
PG 9
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 892WJ
UT WOS:000300316000006
PM 21900943
OA Bronze
DA 2025-06-11
ER

PT J
AU Liu, JR
   Wu, XX
   Franklin, JL
   Messina, JL
   Hill, HS
   Moellering, DR
   Walton, RG
   Martin, M
   Garvey, WT
AF Liu, Jiarong
   Wu, Xuxia
   Franklin, John L.
   Messina, Joseph L.
   Hill, Helliner S.
   Moellering, Douglas R.
   Walton, R. Grace
   Martin, Mitchell
   Garvey, W. Timothy
TI Mammalian Tribbles homolog 3 impairs insulin action in skeletal
   muscle: role in glucose-induced insulin resistance
SO AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
LA English
DT Article
DE glucose toxicity; type 2 diabetes; insulin signaling
ID FUNCTIONAL Q84R POLYMORPHISM; ACTIVATED PROTEIN-KINASE; GLUT4
   TRANSLOCATION; METABOLIC SYNDROME; TRANSPORT SYSTEM; TRB3 EXPRESSION; ER
   STRESS; CELL; DROSOPHILA; MORPHOGENESIS
AB Liu J, Wu X, Franklin JL, Messina JL, Hill HS, Moellering DR, Walton RG, Martin M, Garvey WT. Mammalian Tribbles homolog 3 impairs insulin action in skeletal muscle: role in glucose-induced insulin resistance. Am J Physiol Endocrinol Metab 298: E565-E576, 2010. First published December 8, 2009; doi:10.1152/ajpendo. 00467.2009.-Tribbles homolog 3 (TRIB3) was found to inhibit insulin-stimulated Akt phosphorylation and modulate gluconeogenesis in rodent liver. Currently, we examined a role for TRIB3 in skeletal muscle insulin resistance. Ten insulin-sensitive, ten insulin-resistant, and ten untreated type 2 diabetic (T2DM) patients were metabolically characterized by hyperinsulinemic euglycemic glucose clamps, and biopsies of vastus lateralis were obtained. Skeletal muscle samples were also collected from rodent models including streptozotocin (STZ)-induced diabetic rats, db/db mice, and Zucker fatty rats. Finally, L6 muscle cells were used to examine regulation of TRIB3 by glucose, and stable cell lines hyperexpressing TRIB3 were generated to identify mechanisms underlying TRIB3-induced insulin resistance. We found that 1) skeletal muscle TRIB3 protein levels are significantly elevated in T2DM patients; 2) muscle TRIB3 protein content is inversely correlated with glucose disposal rates and positively correlated with fasting glucose; 3) skeletal muscle TRIB3 protein levels are increased in STZ-diabetic rats, db/db mice, and Zucker fatty rats; 4) stable TRIB3 hyperexpression in muscle cells blocks insulin-stimulated glucose transport and glucose transporter 4 (GLUT4) translocation and impairs phosphorylation of Akt, ERK, and insulin receptor substrate-1 in insulin signal transduction; and 5) TRIB3 mRNA and protein levels are increased by high glucose concentrations, as well as by glucose deprivation in muscle cells. These data identify TRIB3 induction as a novel molecular mechanism in human insulin resistance and diabetes. TRIB3 acts as a nutrient sensor and could mediate the component of insulin resistance attributable to hyperglycemia (i.e., glucose toxicity) in diabetes.
C1 [Wu, Xuxia; Hill, Helliner S.; Moellering, Douglas R.; Walton, R. Grace; Garvey, W. Timothy] Univ Alabama Birmingham, Dept Nutr Sci, Birmingham, AL 35294 USA.
   [Messina, Joseph L.; Garvey, W. Timothy] Univ Alabama Birmingham, Birmingham Vet Affairs Med Ctr, Birmingham, AL 35294 USA.
   [Liu, Jiarong; Franklin, John L.; Messina, Joseph L.] Univ Alabama Birmingham, Dept Pathol, Div Mol & Cellular Pathol, Birmingham, AL 35294 USA.
   [Martin, Mitchell] Hoffmann La Roche Inc, Dept Res Informat Genet & Gen, Preclin Res & Dev, Nutley, NJ 07110 USA.
C3 University of Alabama System; University of Alabama Birmingham; US
   Department of Veterans Affairs; Veterans Health Administration (VHA);
   Veterans Affairs Medical Center - Birmingham; University of Alabama
   System; University of Alabama Birmingham; University of Alabama System;
   University of Alabama Birmingham; Roche Holding; Roche Holding USA
RP Wu, XX (corresponding author), Univ Alabama Birmingham, Dept Nutr Sci, 1675 Univ Blvd, Birmingham, AL 35294 USA.
EM xuxiawu@uab.edu
RI liu, JiaRong/KMA-7122-2024; Garvey, W. Timothy/KVX-9404-2024
OI Moellering, Douglas/0000-0003-2040-4187
FU National Institute of Diabetes and Digestive and Kidney Diseases
   [DK-038764, DK-083562, DK-62071]; National Heart, Lung, and Blood
   Institute [HL-055782]; American Heart Association; Department of Defense
   [W81XWH-0510387]; Merit Review Program of the Department of Veterans
   Affairs; University of Alabama at Birmingham (UAB) Center for Clinical
   and Translational Science [UL1 RR025777]; UAB Clinical Nutrition
   Research Unit [P30-DK56336]; UAB Diabetes Research and Training Center
   [P60-DK079626]
FX This work was supported by National Institute of Diabetes and Digestive
   and Kidney Diseases Grants DK-038764, DK-083562, and DK-62071 and
   National Heart, Lung, and Blood Institute Grant HL-055782, American
   Heart Association Beginning Grant-in-Aid (to X. Wu), the Department of
   Defense (W81XWH-0510387), and the Merit Review Program of the Department
   of Veterans Affairs (to W. T. Garvey and J. L. Messina). We also
   gratefully acknowledge the support of the University of Alabama at
   Birmingham (UAB) Center for Clinical and Translational Science (UL1
   RR025777), the UAB Clinical Nutrition Research Unit (P30-DK56336), and
   the UAB Diabetes Research and Training Center (P60-DK079626).
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NR 66
TC 69
Z9 84
U1 0
U2 9
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0193-1849
EI 1522-1555
J9 AM J PHYSIOL-ENDOC M
JI Am. J. Physiol.-Endocrinol. Metab.
PD MAR
PY 2010
VL 298
IS 3
BP E565
EP E576
DI 10.1152/ajpendo.00467.2009
PG 12
WC Endocrinology & Metabolism; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Physiology
GA 557YA
UT WOS:000274705200020
PM 19996382
OA Green Published
DA 2025-06-11
ER

PT J
AU Stonehouse, W
   Kruger, A
   Smuts, CM
   Loots, DT
   Wentzel-Viljoen, E
   Vorster, HH
AF Stonehouse, Welma
   Kruger, Annamarie
   Smuts, Cornelius M.
   Loots, Du Toit
   Wentzel-Viljoen, Edelweiss
   Vorster, Hester H.
TI Plasma polyunsaturated fatty acids and liver enzymes in HIV-infected
   subjects: the Prospective Urban and Rural Epidemiology (PURE) Study
SO AMERICAN JOURNAL OF CLINICAL NUTRITION
LA English
DT Article
ID GAMMA-GLUTAMYL-TRANSFERASE; OXIDATIVE STRESS; METABOLIC SYNDROME;
   BIOMARKERS; HEALTH; POPULATION; PREDICTOR; MEN
AB Background: Omega-6 (n-6) polyunsaturated fatty acid (PUFA) intake was previously reported to be adversely related to liver function in HIV-infected subjects, when compared with HIV-uninfected subjects, in a black population in South Africa. It was speculated that the use of heavily oxidized vegetable fats (abused fats) could have been responsible.
   Objectives: The objectives were to investigate the relation between plasma total PUFA concentrations (a marker of PUFA intake) and liver enzymes in HIV-infected asymptomatic compared with HIV-uninfected black South Africans and to investigate the reuse of oil and the use of abused oils.
   Design: This was a case-control study nested in an epidemiologic study in 305 HIV-infected cases and 301 HIV-uninfected matched controls (matched according to location, sex, and age), as part of the PURE (Prospective Urban and Rural Epidemiology) Study, a prospective cohort study that includes a representative sample of 2000 apparently healthy black volunteers, aged between 36 and 60 y, from the North West Province of South Africa.
   Results: Plasma total omega-6 PUFA concentrations were negatively (P < 0.05) associated with liver enzymes (gamma-glutamyl transpeptidase, alanine aminotransferase, aspartate aminotranferase, and alkaline phosphatase) in both HIV-infected and HIV-uninfected subjects (r values ranged from -20.22 to -0.56). Almost all subjects (99%) reported that they did not buy oil that had been used before. Oil was only used a mean (+/- SD) of 2.23 +/- 0.85 times for deep frying before being discarded.
   Conclusions: The adverse relations between omega-6 PUFA intake and liver enzymes that were previously shown could not be confirmed in this study. In contrast, plasma omega-6 PUFA concentration was inversely related to liver enzymes in both HIV-infected and HIV-uninfected subjects. Subjects in this study did not use abused fats, which could partly explain these findings. Am J Clin Nutr 2010; 91: 729-35.
C1 [Stonehouse, Welma] Massey Univ, Inst Food Nutr & Human Hlth, N Shore City 0745, Auckland, New Zealand.
   [Kruger, Annamarie; Smuts, Cornelius M.; Loots, Du Toit; Wentzel-Viljoen, Edelweiss; Vorster, Hester H.] North West Univ, Sch Physiol Nutr & Consumer Sci, Potchefstroom, South Africa.
   [Loots, Du Toit] North West Univ, Sch Phys & Chem Sci, Ctr Human Metab, Potchefstroom, South Africa.
C3 Massey University; North West University - South Africa; North West
   University - South Africa
RP Stonehouse, W (corresponding author), Massey Univ, Inst Food Nutr & Human Hlth, Private Bag 102 904, N Shore City 0745, Auckland, New Zealand.
EM w.stonehouse@massey.ac.nz
RI Smuts, Marius/AAJ-5257-2020; Stonehouse, Welma/H-2316-2013; Loots, Du
   Toit/U-1360-2017
OI Stonehouse, Welma/0000-0002-2856-4962; Smuts,
   Cornelius/0000-0003-4829-0054; Loots, Du Toit/0000-0002-0339-6237
FU SANPAD (South Africa-Netherlands Research Programme on Alternatives in
   Development); South African National Research Foundation [2069139,
   FA2006040700010]; North-West University; PHRI; Medical Research Council
   of South Africa; South African Sugar Association
FX Supported by SANPAD (South Africa-Netherlands Research Programme on
   Alternatives in Development), South African National Research Foundation
   (NRF GUN nos. 2069139 and FA2006040700010), North-West University, PHRI,
   Medical Research Council of South Africa, South African Sugar
   Association.
CR Allard JP, 1998, AM J CLIN NUTR, V67, P143, DOI 10.1093/ajcn/67.1.143
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NR 29
TC 7
Z9 7
U1 0
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0002-9165
EI 1938-3207
J9 AM J CLIN NUTR
JI Am. J. Clin. Nutr.
PD MAR
PY 2010
VL 91
IS 3
BP 729
EP 735
DI 10.3945/ajcn.2009.28874
PG 7
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 557YM
UT WOS:000274706500030
PM 20071647
OA Bronze
DA 2025-06-11
ER

PT J
AU Dain, A
   Repossi, G
   Diaz-Gerevini, GT
   Vanamala, J
   Das, UN
   Eynard, AR
AF Dain, Alejandro
   Repossi, Gaston
   Diaz-Gerevini, Gustavo T.
   Vanamala, Jairam
   Das, Undurti N.
   Eynard, Aldo R.
TI Long chain polyunsaturated fatty acids (LCPUFAs) and
   nordihydroguaiaretic acid (NDGA) modulate metabolic and inflammatory
   markers in a spontaneous type 2 diabetesmellitus model (Stillman Salgado
   rats)
SO LIPIDS IN HEALTH AND DISEASE
LA English
DT Article
DE Type 2 diabetes; eSS rats (Stillman Salgado rats); PUFAs; Chronic
   inflammation; Oxidation process; Plasma triglycerides;
   Nordihydroguaiaretic acid
ID SYNDROME-X; DESATURASE ACTIVITY; OXIDATIVE STRESS; DELTA-5 DESATURASE;
   CLINICAL-IMPLICATIONS; INSULIN-RESISTANCE; MELLITUS; PREVENTION;
   GLUCOSE; CANCER
AB Background: Diabetes mellitus (DM) is a complex disease with alterations in metabolic and inflammatory markers. Stillman Salgado rats (eSS) spontaneously develop type 2 DM by middle age showing progressive impairment of glucose tolerance with hyperglycemia, hypertriglyceridemia and hyperinsulinemia. We analyzed the effects of supplementation of omega-3 and omega-6 polyunsaturated fatty acids (PUFAs) with or without nordihydroguaiaretic acid (NDGA) added, an antioxidant and lipoxygenase inhibitor, on metabolic and inflammatory parameters in eSS rats to evaluate whether they can delay development and/or prevent progression of DM.
   Methods: After weaning, eSS rats received, intraperitoneally, once a month omega-3 (EPA 35% and DHA 40%-6.25mg/Kg) or omega-6 (90% arachidonic acid-6. 25 mg/Kg) for twelvemonths. Two additional groups of rats received 1.9 mg/kg NDGA added to omega-3 and omega-6 fatty acids. Blood samples were collected at day 40, and at the end of the 6thmonth and 12thmonth of age to determine plasma triglycerides (TGs), total plasma fatty acids (FA), A1C hemoglobin (HbA1C), C-reactive protein (CRP), gamma glutamyl transpeptidase (GGT), lipo and hydro peroxides, nitrites and IL-6 (in plasma and liver, kidney, and pancreas) and underwent oral glucose tolerance test (OGTT) as well. Wistar and eSS rats that received saline solution were used as controls.
   Results: Plasma lipids profile, TG, fasting and post-prandial blood glucose levels, and glycosylated HbA1C showed significant improvements in omega-3 and omega-3 + NDGA treated animals compared to eSS control group. omega-3 and omega-3 + NDGA groups showed an inverse correlation with fasting blood glucose and showed lower plasma levels of GGT, TG, and CRP. eSS rats treated with omega-3 LCPUFAs showed reduced level of inflammatory and oxidative indices in plasma and liver, kidney and pancreas tissues in comparison with eSS control (non-treated) and omega-6 treated groups.
   Conclusions: eSS rats are a useful model to study type 2 DM pathophysiology and related inflammatory indices. omega-3 + NDGA supplementation, at the doses tested, ameliorated inflammatory, metabolic and oxidative stress markers studied.
C1 [Dain, Alejandro; Repossi, Gaston; Diaz-Gerevini, Gustavo T.; Eynard, Aldo R.] Univ Nacl Cordoba, CONICET, INICSA, Biol Celular Histol & Embriol,Fac Ciencias Med, Cordoba, Argentina.
   [Repossi, Gaston] Univ Nacl La Rioja, Catedra Histol Embriol & Genet, La Rioja, Argentina.
   [Repossi, Gaston; Eynard, Aldo R.] Consejo Nacl Invest Cient & Tecn, Cordoba, Argentina.
   [Vanamala, Jairam] Penn State Univ, Dept Food Sci, 326 Food Sci Bldg, University Pk, PA 16802 USA.
   [Das, Undurti N.] UND Life Sci, 2020 S 360th St,K-202, Federal Way, WA 98003 USA.
   [Das, Undurti N.] GVP Hosp, BioSci Res Ctr, Gayatri Vidya Parishad Coll Engn Campus, Visakhapatnam 530048, Andhra Pradesh, India.
   [Das, Undurti N.] GVP Hosp, Dept Med, Gayatri Vidya Parishad Coll Engn Campus, Visakhapatnam 530048, Andhra Pradesh, India.
C3 Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET);
   National University of Cordoba; Consejo Nacional de Investigaciones
   Cientificas y Tecnicas (CONICET); Pennsylvania Commonwealth System of
   Higher Education (PCSHE); Pennsylvania State University; Penn State
   Behrend; Pennsylvania State University - University Park; Gayatri Vidya
   Parishad College of Engineering; Gayatri Vidya Parishad College of
   Engineering
RP Eynard, AR (corresponding author), Univ Nacl Cordoba, CONICET, INICSA, Biol Celular Histol & Embriol,Fac Ciencias Med, Cordoba, Argentina.; Eynard, AR (corresponding author), Consejo Nacl Invest Cient & Tecn, Cordoba, Argentina.; Das, UN (corresponding author), UND Life Sci, 2020 S 360th St,K-202, Federal Way, WA 98003 USA.; Das, UN (corresponding author), GVP Hosp, BioSci Res Ctr, Gayatri Vidya Parishad Coll Engn Campus, Visakhapatnam 530048, Andhra Pradesh, India.; Das, UN (corresponding author), GVP Hosp, Dept Med, Gayatri Vidya Parishad Coll Engn Campus, Visakhapatnam 530048, Andhra Pradesh, India.
EM Undurti@hotmail.com; aeynard@gmail.com
RI Das, Undurti/A-7918-2009
FU Department of Biotechnology (DBT) [BT/PR11627/MED/30/157/2010];
   Department of Science and Technology under Intensification of Research
   in High Priority Areas (IRPHA) [IR/SO/LU/03/2008/1]; Defence Research
   and Development Organization, New Delhi [(sic)TC/2519/INM -
   03/2011/CARS, INM-311]; CONICET (Argentina); SECYT-UNC (Argentina);
   SECYT-UNLaR (Argentina)
FX This work was supported, in part, by grants from the Department of
   Biotechnology (DBT No. BT/PR11627/MED/30/157/2010), Department of
   Science and Technology (No. IR/SO/LU/03/2008/1) under Intensification of
   Research in High Priority Areas (IRPHA), and Defence Research and
   Development Organization, New Delhi ((sic)TC/2519/INM - 03/2011/CARS]
   under R&D Project INM-311) to UND.This work was supported, in part, by
   the funds provided by CONICET, SECYT-UNC and SECYT-UNLaR (Argentina).
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NR 64
TC 16
Z9 18
U1 0
U2 10
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1476-511X
J9 LIPIDS HEALTH DIS
JI Lipids Health Dis.
PD NOV 25
PY 2016
VL 15
AR 205
DI 10.1186/s12944-016-0363-8
PG 15
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA ED3TD
UT WOS:000388770500001
PM 27884155
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Di Cristo, V
   Adorni, F
   Maserati, R
   Lodi, MA
   Bruno, G
   Maggi, P
   Volpe, A
   Vitiello, P
   Abeli, C
   Bonora, S
   Ferrara, M
   Cossu, MV
   Oreni, ML
   Colella, E
   Rusconi, S
AF Di Cristo, Valentina
   Adorni, Fulvio
   Maserati, Renato
   Annovazzi Lodi, Marco
   Bruno, Giuseppe
   Maggi, Paolo
   Volpe, Anna
   Vitiello, Paola
   Abeli, Clara
   Bonora, Stefano
   Ferrara, Micol
   Cossu, Maria Vittoria
   Oreni, Maria Letizia
   Colella, Elisa
   Rusconi, Stefano
TI 96-week results of a dual therapy with darunavir/ritonavir plus
   rilpivirine once a day vs triple therapy in patients with
   suppressed viraemia: virological success and non-HIV related morbidity
   evaluation
SO HIV RESEARCH & CLINICAL PRACTICE
LA English
DT Article
DE HIV-1; Darunavir; Rilpivirine; Dual therapy; Immunovirological success;
   Safety
ID METABOLIC SYNDROME; OPEN-LABEL; MAINTENANCE; LAMIVUDINE; TENOFOVIR
AB Antiretroviral therapies have been tested with the goal of maintaining virological suppression with a particular attention in limiting drug-related toxicity. With this aim we designed the DUAL study: a randomized, open-label, multicenter, 96 weeks-long pilot exploratory study in virologically suppressed HIV-1+ patients with the aim of evaluating the immunovirological success and the impact on non-HIV related morbidity of switching to a dual therapy with darunavir-ritonavir (DRV/r) and rilpivirine (RPV). We recruited patients who received a PI/r-containing HAART for >= 6 months, HIV-RNA < 50 cp/mL for >= 3 months, eGFR > 60 mL/min/1,73m2, without DRV or RPV RAMs. We randomized patients in arm A: RPV + DRV/r QD or arm B: ongoing triple therapy. The primary endpoint has been defined as the percentage of patients with HIV-RNA < 50 cp/mL at week 48 (ITT). VACS index, Framingham CVD risk (FRS) and urinary RBP (uRBP) were calculated. We used Chi-square or Fisher statistics for categorical variables and Mann-Whitney U for continuous ones. Forty-one patients were enrolled (22 in arm A, 14 in arm B, plus 5 screening failures): 30 patients reached 96 weeks: 100% had HIV-RNA < 50 cp/mL in arm A versus 91.7% in arm B. Similar changes were observed in median CD4/mL between baseline and week 96 (+59 versus - 31, p: n.s.). Thirty-one in arm A and 23 in arm B adverse events took place, whereas only 1 was serious (arm A: turbinate hypertrophy, unrelated to HAART). Among the 6 discontinuations (3 in A, 3 in B), only 1 was related to adverse event (arm A: G3 depression, insomnia, weakness). VACS index, median FRS and median uRBP values did not vary from baseline to week 96. At 96-weeks all patients switched to a QD 2-drug regimen based on DRV/r + RPV maintained HIV-RNA suppression, but a single patient who showed a virological failure at week 4. CD4 counts increased overtime without significant differences between the two arms. The novel dual regimen was well tolerated with the same amount of discontinuation as the control arm. VACS index, FRS and uRBP did not differ between arms at week 96.
C1 [Di Cristo, Valentina; Oreni, Maria Letizia; Colella, Elisa; Rusconi, Stefano] Univ Milan, DIBIC Luigi Sacco, Infect Dis Unit, Via GB Grassi 74, I-20157 Milan, Italy.
   [Adorni, Fulvio] CNR, ITB, Segrate, MI, Italy.
   [Maserati, Renato; Annovazzi Lodi, Marco] Policlin San Matteo Fdn, IRCCS, Infect Dis Unit, Pavia, Italy.
   [Bruno, Giuseppe; Maggi, Paolo; Volpe, Anna] Univ Bari, Infect Dis Unit, Bari, Italy.
   [Vitiello, Paola; Abeli, Clara] ASST Valle Olona, Osped Circolo, Infect Dis Unit, Busto Arsizio, VA, Italy.
   [Bonora, Stefano; Ferrara, Micol] Univ Turin, Infect Dis Unit, Turin, Italy.
   [Cossu, Maria Vittoria] ASST Fatebenefratelli Sacco, Infect Dis Unit 1, Milan, Italy.
   [Di Cristo, Valentina] Ctr Riferimento HIV & Malattie Sessualmente Trasm, Milan, Italy.
   [Bruno, Giuseppe] Osped Oncol San Giuseppe Moscati, Infect & Trop Dis Unit, Taranto, TA, Italy.
   [Maggi, Paolo] Univ Campania Luigi Vanvitelli, Infect Dis Unit, Caserta, CE, Italy.
   [Vitiello, Paola] San Gerardo Hosp, Infect Dis Unit, Monza, MB, Italy.
C3 University of Milan; Luigi Sacco Hospital; Consiglio Nazionale delle
   Ricerche (CNR); Istituto di Tecnologie Biomediche (ITB-CNR); University
   of Pavia; IRCCS Fondazione San Matteo; Universita degli Studi di Bari
   Aldo Moro; University of Turin; Universita della Campania Vanvitelli;
   San Gerardo Hospital
RP Rusconi, S (corresponding author), Univ Milan, DIBIC Luigi Sacco, Infect Dis Unit, Via GB Grassi 74, I-20157 Milan, Italy.
EM stefano.rusconi@unimi.it
RI Cossu, Maria Vittoria/LSK-8057-2024; Maggi, Paolo/K-6598-2016; Bonora,
   Stefano/D-6767-2011; Rusconi, Stefano/H-9263-2012; Adorni,
   Fulvio/P-7064-2018
OI Rusconi, Stefano/0000-0002-0375-9990; Adorni,
   Fulvio/0000-0001-6264-6876; cossu, maria vittoria/0000-0002-6984-3028;
   Ferrara, Micol/0000-0003-0377-9630
FU IIR grant from Janssen-Cilag (Cologno Monzese, Italy)
FX This study was supported by an IIR grant to Stefano Rusconi from
   Janssen-Cilag (Cologno Monzese, Italy).
CR BHIVA (British HIV Association), TREATM HIV 1 POS AD
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   van Wyk J, 2020, CLIN INFECT DIS
NR 24
TC 6
Z9 6
U1 0
U2 8
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 2578-7489
EI 2578-7470
J9 HIV RES CLIN PRACT
JI HIV Res. Clin. Pract.
PY 2020
VL 21
IS 1
BP 34
EP 43
DI 10.1080/25787489.2020.1734752
EA MAR 2020
PG 10
WC Infectious Diseases; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases; Pharmacology & Pharmacy
GA OQ3UP
UT WOS:000518625400001
PM 32129161
DA 2025-06-11
ER

PT J
AU Pladevall-Vila, M
   Pottegård, A
   Schink, T
   Reutfors, J
   Morros, R
   Poblador-Plou, B
   Timmer, A
   Forns, J
   Hellfritzsch, M
   Reinders, T
   Hägg, D
   Giner-Soriano, M
   Prados-Torres, A
   Cainzos-Achirica, M
   Hallas, J
   Brandt, L
   Cortés, J
   Aguado, J
   Perlemuter, G
   Falissard, B
   Castellsagué, J
   Jacquot, E
   Deltour, N
   Perez-Gutthann, S
AF Pladevall-Vila, Manel
   Pottegard, Anton
   Schink, Tania
   Reutfors, Johan
   Morros, Rosa
   Poblador-Plou, Beatriz
   Timmer, Antje
   Forns, Joan
   Hellfritzsch, Maja
   Reinders, Tammo
   Hagg, David
   Giner-Soriano, Maria
   Prados-Torres, Alexandra
   Cainzos-Achirica, Miguel
   Hallas, Jesper
   Brandt, Lena
   Cortes, Jordi
   Aguado, Jaume
   Perlemuter, Gabriel
   Falissard, Bruno
   Castellsague, Jordi
   Jacquot, Emmanuelle
   Deltour, Nicolas
   Perez-Gutthann, Susana
TI Risk of Acute Liver Injury in Agomelatine and Other Antidepressant Users
   in Four European Countries: A Cohort and Nested Case-Control Study Using
   Automated Health Data Sources
SO CNS DRUGS
LA English
DT Article
ID DIAGNOSTIC CODES; DULOXETINE; VALIDITY; OUTCOMES; EVENTS
AB BackgroundAgomelatine is a melatonin receptor agonist and serotonin 5-HT2C receptor antagonist indicated for depression in adults. Hepatotoxic reactions like acute liver injury (ALI) are an identified risk in the European risk management plan for agomelatine. Hepatotoxic reactions have been reported for other antidepressants, but population studies quantifying these risks are scarce. Antidepressants are widely prescribed, and users often have risk factors for ALI (e.g. metabolic syndrome).ObjectiveThe goal was to estimate the risk of ALI associated with agomelatine and other antidepressants (fluoxetine, paroxetine, sertraline, escitalopram, mirtazapine, venlafaxine, duloxetine, and amitriptyline) when compared with citalopram in routine clinical practice.MethodA nested case-control study was conducted using data sources in Denmark, Germany, Spain, and Sweden (study period 2009-2014). Three ALI endpoints were defined using International Classification of Diseases (ICD) codes: primary (specific codes) and secondary (all codes) endpoints used only hospital discharge codes; the tertiary endpoint included both inpatient and outpatient settings (all codes). Validation of endpoints was implemented. Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for current use were estimated for each data source and combined.ResultsWe evaluated 3,238,495 new antidepressant and 74,440 agomelatine users. For the primary endpoint, the OR for agomelatine versus citalopram was 0.48 (CI 0.13-1.71). Results were also<1 when no exclusion criteria were applied (OR 0.37; CI 0.19-0.74), when all exclusion criteria except alcohol and drug abuse were applied (OR 0.47; CI 0.20-1.07), and for the secondary (OR 0.40; CI 0.05-3.11) and tertiary (OR 0.79; CI 0.50-1.25) endpoints. Regarding other antidepressants versus citalopram, most OR point estimates were also below one, although with varying widths of the 95% CIs. The result of the tertiary endpoint and the sensitivity analyses of the primary endpoint were the most precise.ConclusionIn this study, using citalopram as a comparator, agomelatine was not associated with an increased risk of ALI hospitalisation. The results for agomelatine should be interpreted in the context of the European risk minimisation measures in place. Those measures may have induced selective prescribing and could explain the lower risk of ALI for agomelatine when compared with citalopram. Most other antidepressants evaluated had ORs suggesting a lower risk than citalopram, but additional studies are required to confirm or refute these results.
C1 [Pladevall-Vila, Manel; Forns, Joan; Cainzos-Achirica, Miguel; Aguado, Jaume; Castellsague, Jordi; Perez-Gutthann, Susana] RTI Hlth Solut, Epidemiol, Ave Diagonal 605,9-1, Barcelona 08028, Spain.
   [Pladevall-Vila, Manel] Henry Ford Hlth Syst, Ctr Hlth Policy & Hlth Serv Res, Detroit, MI 48202 USA.
   [Pottegard, Anton; Hellfritzsch, Maja; Hallas, Jesper] Univ Southern Denmark, Dept Publ Hlth, Clin Pharmacol & Pharm, Odense, Denmark.
   [Schink, Tania; Reinders, Tammo] Leibniz Inst Prevent Res & Epidemiol BIPS, Bremen, Germany.
   [Reutfors, Johan; Hagg, David; Brandt, Lena] Karolinska Inst, Karolinska Univ Hosp, Dept Med, Ctr Pharmacoepidemiol, Stockholm, Sweden.
   [Morros, Rosa; Giner-Soriano, Maria; Cortes, Jordi] Inst Univ Invest Atencio Primaria Jordi Gol IDIAP, Barcelona, Spain.
   [Morros, Rosa; Giner-Soriano, Maria; Cortes, Jordi] Univ Autonoma Barcelona, Bellaterra, Cerdanyola Del, Spain.
   [Morros, Rosa; Giner-Soriano, Maria; Cortes, Jordi] Inst Catala Salut, Barcelona, Spain.
   [Morros, Rosa] UICEC IDIAP Jordi Gol, Plataforma SCReN, Barcelona, Spain.
   [Poblador-Plou, Beatriz; Prados-Torres, Alexandra] Miguel Servet Univ Hosp, EpiChron Res Grp, Aragon Hlth Sci Inst IACS, IIS Aragon,REDISSEC ISCIII, Zaragoza, Spain.
   [Timmer, Antje] Carl von Ossietzky Univ Oldenburg, Fac Med, Div Epidemiol & Biometry, Oldenburg, Germany.
   [Cortes, Jordi] Univ Politecn Cataluna, Dept Estadist & Invest Operat, Barcelona, Spain.
   [Perlemuter, Gabriel] Hop Antoine Beclere, AP HP, Serv Hepatogastroenterol, F-92140 Clamart, France.
   [Perlemuter, Gabriel] Univ Paris Sud Paris Saclay, Fac Med, F-94270 Le Kremlin Bicetre, France.
   [Perlemuter, Gabriel] INSERM U996, F-92140 Clamart, France.
   [Falissard, Bruno] Univ Paris Sud, Univ Paris Saclay, AP HP, CESP INSERM U1018,UVSQ, Paris, France.
   [Jacquot, Emmanuelle; Deltour, Nicolas] Servier, Pharmacoepidemiol Dept, Suresnes, France.
C3 Research Triangle Institute; Henry Ford Health System; Henry Ford
   Hospital; University of Southern Denmark; Leibniz Association; Leibniz
   Institute for Prevention Research & Epidemiology (BIPS); Karolinska
   Institutet; Karolinska University Hospital; Autonomous University of
   Barcelona; Miguel Servet University Hospital; Carl von Ossietzky
   Universitat Oldenburg; Universitat Politecnica de Catalunya; Assistance
   Publique Hopitaux Paris (APHP); Hopital Universitaire Antoine-Beclere -
   APHP; Universite Paris Saclay; Institut National de la Sante et de la
   Recherche Medicale (Inserm); Assistance Publique Hopitaux Paris (APHP);
   Universite Paris Saclay; Institut National de la Sante et de la
   Recherche Medicale (Inserm); Servier
RP Pladevall-Vila, M (corresponding author), RTI Hlth Solut, Epidemiol, Ave Diagonal 605,9-1, Barcelona 08028, Spain.; Pladevall-Vila, M (corresponding author), Henry Ford Hlth Syst, Ctr Hlth Policy & Hlth Serv Res, Detroit, MI 48202 USA.
EM mpladevall@rti.org
RI Rouquette, Alexandra/AGY-2116-2022; Poblador-Plou,
   Beatriz/ABC-7915-2020; Cortes, Jordi/P-6563-2017; Schink,
   Tania/A-4585-2017; Timmer, Antje/N-8056-2015; Prados-Torres,
   Alexandra/P-5818-2017; Giner-Soriano, Maria/H-7419-2019
OI Hallas, Jesper/0000-0002-8097-8708; Cortes, Jordi/0000-0002-3764-0795;
   Reinders, Tammo/0000-0003-2684-7413; Pottegard,
   Anton/0000-0001-9314-5679; Schink, Tania/0000-0002-0224-1866; DELTOUR,
   Nicolas/0000-0003-3477-7021; Timmer, Antje/0000-0001-9579-0516; Forns,
   Joan/0000-0002-1066-0358; Prados-Torres, Alexandra/0000-0002-5704-6056;
   Poblador-Plou, Beatriz/0000-0002-5119-5093; Aguado,
   Jaume/0000-0002-9575-0212; Perez-Gutthann, Susana/0000-0001-5798-3691;
   Giner-Soriano, Maria/0000-0003-3750-9233
FU Servier
FX This study was funded by Servier under a contract granting independent
   publication rights to the research team. Servier co-authors of this
   manuscript, Emmanuelle Jacquot and Nicolas Deltour, provided feedback
   and contributed to the design of the study. The sponsor had the
   opportunity to review the report and contribute to the dissemination of
   the results. The open access fee was paid by RTI-HS with general funds
   from the study account, which was funded by Servier.
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NR 51
TC 21
Z9 21
U1 0
U2 7
PU ADIS INT LTD
PI NORTHCOTE
PA 5 THE WAREHOUSE WAY, NORTHCOTE 0627, AUCKLAND, NEW ZEALAND
SN 1172-7047
EI 1179-1934
J9 CNS DRUGS
JI CNS Drugs
PD APR
PY 2019
VL 33
IS 4
BP 383
EP 395
DI 10.1007/s40263-019-00611-9
PG 13
WC Clinical Neurology; Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA HR3XY
UT WOS:000463077500007
PM 30830574
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Tek, C
   Guloksuz, S
   Srihari, VH
   Reutenauer, EL
AF Tek, Cenk
   Guloksuz, Sinan
   Srihari, Vinod H.
   Reutenauer, Erin L.
TI Investigating the safety and efficacy of naltrexone for anti-psychotic
   induced weight gain in severe mental illness: study protocol of a
   double-blind, randomized, placebo-controlled trial
SO BMC PSYCHIATRY
LA English
DT Article
DE Naltrexone; Schizophrenia; Severe Mental Illness; Obesity; Metabolic
   Syndrome; Weight Loss; Antipsychotics
ID QUALITY-OF-LIFE; PHYSICAL-ACTIVITY; MEDICATION COMPLIANCE;
   SCHIZOPHRENIA; OBESITY; RISK; INDIVIDUALS; OPIOIDS; QUESTIONNAIRE;
   RIBOFLAVIN
AB Background: Obesity is a growing health problem leading to high rates of mortality and morbidity in patients with severe mental illness (SMI). The increased rate of obesity is largely attributed to antipsychotic use. The effect of antipsychotic medications on H1 and 5HT2 receptors has been associated with weight gain, but there is also a substantial amount of evidence showing that D2 receptor blockade may be responsible for weight gain by interacting with the dopamine-opioid system. Unfortunately, current available medications for weight loss have limited efficacy in this population. Naltrexone, an opioid receptor antagonist, may be a promising agent to reduce antipsychotic induced weight gain by decreasing food cravings. We aim to investigate the safety and efficacy of two doses of naltrexone (25 mg & 50 mg) versus placebo for weight and health risk reduction in overweight and obese individuals (BMI >= 28) with SMI, who gained weight while being treated with antipsychotics.
   Methods and design: One hundred and forty four patients will be recruited throughout the greater New Haven area. The participants will be randomized to naltrexone 25 mg/day, naltrexone 50 mg/day, or placebo in a 1:1:1 ratio. Participants will be on the study medication for 52 weeks, and assessed weekly for the first 4 weeks and bi-weekly thereafter. The primary outcome measurements are weight reduction and percentage achieving clinically significant weight loss (5% of total body weight). Waist circumference, body mass index, serum lipid profile, fasting glucose, and glycosylated hemoglobin are the secondary outcome measures. The effect of naltrexone on other outcome measurements such as schizophrenia symptoms, depression, dietary consumption, quality of life, cognitive functioning, physical activity, metabolism/inflammation markers, serum leptin, ghrelin, peptide YY, adinopectin, high sensitivity CRP, interleukin 6, interleukin-1B, interleukin-18, and tumor necrosis factor alpha (TNF-alpha) will be evaluated. The data will be analyzed by applying linear mixed effect models.
   Discussion: This is the first large scale study investigating the safety and efficacy of naltrexone in antipsychotic induced weight gain; and hopefully, this may lead to a novel pharmacological option for management of this major health problem.
   Trial registration: This trial is registered in www.clinicaltrials.gov as NCT01866098
C1 [Tek, Cenk; Guloksuz, Sinan; Srihari, Vinod H.; Reutenauer, Erin L.] Yale Univ, Sch Med, Dept Psychiat, New Haven, CT 06520 USA.
C3 Yale University
RP Tek, C (corresponding author), Yale Univ, Sch Med, Dept Psychiat, New Haven, CT 06520 USA.
EM cenk.tek@yale.edu
RI Guloksuz, Sinan/AAH-1076-2019; Tek, Cenk/M-1552-2019; Srihari,
   Vinod/B-9040-2018
OI Guloksuz, Sinan/0000-0002-6626-1874; Srihari, Vinod/0000-0003-1556-2332
FU National Institute of Diabetes and Digestive and Kidney Diseases
   (NIHDDK) at the National Institutes of Health [1R01 DK093924]; Women's
   Health Research at Yale (WHRY)
FX This research was supported by grant number 1R01 DK093924 from the
   National Institute of Diabetes and Digestive and Kidney Diseases
   (NIHDDK) at the National Institutes of Health. Pilot research leading to
   the development of this project was supported by a Pilot Project Grant
   from Women's Health Research at Yale (WHRY).
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NR 62
TC 16
Z9 18
U1 0
U2 24
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1471-244X
J9 BMC PSYCHIATRY
JI BMC Psychiatry
PD JUN 27
PY 2013
VL 13
AR 176
DI 10.1186/1471-244X-13-176
PG 10
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychiatry
GA 177HL
UT WOS:000321366000001
PM 23805859
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU De Long, NE
   Hardy, DB
   Ma, N
   Holloway, AC
AF De Long, Nicole E.
   Hardy, Daniel B.
   Ma, Noelle
   Holloway, Alison C.
TI Increased incidence of non-alcoholic fatty liver disease in male rat
   offspring exposed to fluoxetine during fetal and neonatal life involves
   the NLRP3 inflammasome and augmented de novo hepatic lipogenesis
SO JOURNAL OF APPLIED TOXICOLOGY
LA English
DT Article
DE developmental origins of disease; dyslipidemia; histone acetylation;
   inflammasome; metabolic syndrome; non-alcoholic fatty liver disease;
   post-translational histone modifications; selective serotonin reuptake
   inhibitors; triglycerides
ID SEROTONIN REUPTAKE INHIBITORS; LIPID-ACCUMULATION; ANTIDEPRESSANT USE;
   DNA METHYLATION; DEPRESSION; EPIDEMIOLOGY; PREVALENCE; ACTIVATION;
   PREGNANCY; ACIDS
AB Up to 10% of women take selective serotonin reuptake inhibitors (SSRI) during pregnancy. Children exposed to SSRIs in utero have an increased risk of being overweight suggesting that fetal exposure to SSRIs can cause permanent metabolic changes. We have previously shown in rats that fetal and neonatal exposure to the SSRI antidepressant fluoxetine results in metabolic perturbations including increased hepatic triglyceride content; a hallmark of non-alcoholic fatty liver disease (NAFLD). Therefore, the aim of this study was to identify the mechanism(s) underlying the fluoxetine-induced increase in intrahepatic triglyceride content. Female nulliparous Wistar rats were given vehicle or fluoxetine (10mg/kg/day) orally for 2weeks prior to mating until weaning. At 6months of age, we assessed whether SSRI exposure altered components of the hepatic triglyceride biosynthesis pathway in the offspring and examined the molecular mechanisms underlying these changes. Male SSRI-exposed offspring had a significant increase in the steady-state mRNA levels of Elovl6 and Dgat1 and core components of the NLRP3 inflammasome (apoptosis-associated speck-like protein containing a caspase activation recruitment domain [ASC] and caspase-1). Augmented expression of Asc in the SSRI-exposed offspring coincided with increased histone acetylation in the proximal promoter region. Given that we have previously demonstrated that antenatal exposure to SSRIs can lead to fatty liver in the offspring, this raises concerns regarding the long-term metabolic sequelae of fetal SSRI exposure. Moreover, this study suggests that elevated hepatic triglyceride levels observed in the SSRI-exposed offspring may be due, in part, to activation of the NLRP3 inflammasome and augmentation of de novo lipogenesis.
   There is limited information available regarding the long-term metabolic consequences of fetal and neonatal exposure to selective serotonin reuptake inhibitors (SSRI) antidepressants. The present study demonstrates that in male SSRI-exposed offspring at 6 months, the increase in the prevalence of fatty liver is associated with upregulation of genes important for de novo lipogenesis and activation of the NLRP3 inflammasome. This suggests that early life exposure to SSRIs may increase the risk of developing chronic liver disease in postnatal life.
C1 [De Long, Nicole E.; Holloway, Alison C.] McMaster Univ, Dept Obstet & Gynecol, RM HSC 3N52,1280 Main St West, Hamilton, ON L8S 4K1, Canada.
   [Hardy, Daniel B.; Ma, Noelle] Univ Western Ontario, Dept Obstet & Gynecol Physiol & Pharmacol, London, ON N6A 3K6, Canada.
C3 McMaster University; Western University (University of Western Ontario)
RP Holloway, AC (corresponding author), McMaster Univ, Dept Obstet & Gynecol, RM HSC 3N52,1280 Main St West, Hamilton, ON L8S 4K1, Canada.
EM hollow@mcmaster.ca
RI Hardy, Daniel/GYU-8976-2022
OI Holloway, Alison/0000-0002-4343-5325; Hardy, Daniel/0000-0001-5445-273X
FU Canadian Institutes of Health Research [MOP111001, MOP119323]; CIHR
   Training Program in Reproduction, Early Development and the Impact on
   Health (REDIH)
FX Canadian Institutes of Health Research, MOP111001 and MOP119323; CIHR
   Training Program in Reproduction, Early Development and the Impact on
   Health (REDIH)
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NR 63
TC 9
Z9 9
U1 0
U2 13
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0260-437X
EI 1099-1263
J9 J APPL TOXICOL
JI J. Appl. Toxicol.
PD DEC
PY 2017
VL 37
IS 12
BP 1507
EP 1516
DI 10.1002/jat.3502
PG 10
WC Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Toxicology
GA FK2LP
UT WOS:000413314000015
PM 28677866
DA 2025-06-11
ER

PT J
AU Blonde, L
   Umpierrez, GE
   Reddy, SS
   McGill, JB
   Berga, SL
   Bush, M
   Chandrasekaran, S
   DeFronzo, RA
   Einhorn, D
   Gardner, TW
   Garg, R
   Garvey, WT
   Hirsch, IB
   Hurley, DL
   Izuora, K
   Kosiborod, M
   Olson, D
   Patel, SB
   Pop-Busui, R
   Sadhu, AR
   Samson, SL
   Stec, C
   Tamborlane, WV 
   Tuttle, KR
   Twining, C
   Vella, A
   Vellanki, P
   Weber, SL
AF Blonde, Lawrence
   Umpierrez, Guillermo E.
   Reddy, S. Sethu
   McGill, Janet B.
   Berga, Sarah L.
   Bush, Michael
   Chandrasekaran, Suchitra
   DeFronzo, Ralph A.
   Einhorn, Daniel
   Gardner, Thomas W.
   Garg, Rajesh
   Garvey, W. Timothy
   Hirsch, Irl B.
   Hurley, Daniel L.
   Izuora, Kenneth
   Kosiborod, Mikhail
   Olson, Darin
   Patel, Shailendra B.
   Pop-Busui, Rodica
   Sadhu, Archana R.
   Samson, Susan L.
   Stec, Carla
   Tamborlane, William V., Jr.
   Tuttle, Katherine R.
   Twining, Christine
   Vella, Adrian
   Vellanki, Priyathama
   Weber, Sandra L.
TI American Association of Clinical Endocrinology Clinical Practice
   Guideline: Developing a Diabetes Mellitus Comprehensive Care Plan-2022
   Update
SO ENDOCRINE PRACTICE
LA English
DT Article
DE antihyperglycemic medications; atherosclerotic cardiovascular disease;
   cardiovascular diseases; diabetes; gestational; diabetes mellitus;
   diabetes mellitus, type 1; diabetes mellitus, type 2; diabetic
   nephropathies; diabetic neuropathies; diabetic retinopathy;
   dyslipidemias; guideline; hospitalization; hypertension; hypoglycemia;
   infertility; interdisciplinary communication; metabolic syndrome;
   obesity; occupations; prediabetic state; pregnancy; secondary diabetes;
   sleep apnea syndromes; telemedicine; vaccination
ID CHRONIC KIDNEY-DISEASE; RANDOMIZED CONTROLLED-TRIAL; LIFE-STYLE
   INTERVENTION; CORONARY-HEART-DISEASE; CARDIOVASCULAR RISK-FACTORS;
   INTENSIVE INSULIN THERAPY; DENSITY-LIPOPROTEIN-CHOLESTEROL;
   SELF-MANAGEMENT EDUCATION; OBSTRUCTIVE SLEEP-APNEA; ALL-CAUSE MORTALITY
AB Objective: The objective of this clinical practice guideline is to provide updated and new evidence-based recommendations for the comprehensive care of persons with diabetes mellitus to clinicians, diabetes-care teams, other health care professionals and stakeholders, and individuals with diabetes and their caregivers.
   Methods: The American Association of Clinical Endocrinology selected a task force of medical experts and staff who updated and assessed clinical questions and recommendations from the prior 2015 version of this guideline and conducted literature searches for relevant scientific papers published from January 1, 2015, through May 15, 2022. Selected studies from results of literature searches composed the evidence base to update 2015 recommendations as well as to develop new recommendations based on review of clinical evidence, current practice, expertise, and consensus, according to established American Association of Clinical Endocrinology protocol for guideline development.
   Results: This guideline includes 170 updated and new evidence-based clinical practice recommendations for the comprehensive care of persons with diabetes. Recommendations are divided into four sections: (1) screening, diagnosis, glycemic targets, and glycemic monitoring; (2) comorbidities and complications, including obesity and management with lifestyle, nutrition, and bariatric surgery, hypertension, dyslipidemia, retinopathy, neuropathy, diabetic kidney disease, and cardiovascular disease; (3) management of prediabetes, type 2 diabetes with antihyperglycemic pharmacotherapy and glycemic targets, type 1 diabetes with insulin therapy, hypoglycemia, hospitalized persons, and women with diabetes in pregnancy; (4) education and new topics regarding diabetes and infertility, nutritional supplements, secondary diabetes, social determinants of health, and virtual care, as well as updated recommendations on cancer risk, nonpharmacologic components of pediatric care plans, depression, education and team approach, occupational risk, role of sleep medicine, and vaccinations in persons with diabetes.
   Conclusions: This updated clinical practice guideline provides evidence-based recommendations to assist with person-centered, team-based clinical decision-making to improve the care of persons with diabetes mellitus. (c) 2022 AACE. Published by Elsevier Inc. All rights reserved.
C1 [Blonde, Lawrence] Ochsner Hlth, New Orleans, LA USA.
   [Umpierrez, Guillermo E.; Chandrasekaran, Suchitra; Weber, Sandra L.] Emory Univ, Atlanta, GA USA.
   [Reddy, S. Sethu] Cent Michigan Univ, Mt Pleasant, MI USA.
   [McGill, Janet B.] Washington Univ St Louis, St Louis, MO USA.
   [Berga, Sarah L.] SUNY Buffalo, Buffalo, NY USA.
   [Bush, Michael] Cedars Sinai, Beverly Hills, CA USA.
   [DeFronzo, Ralph A.] Univ Texas San Antonio, San Antonio, TX USA.
   [Einhorn, Daniel] Scripps Whittier Diabet Inst, La Jolla, CA USA.
   [Gardner, Thomas W.; Pop-Busui, Rodica] Univ Michigan, Ann Arbor, MI USA.
   [Garg, Rajesh] Harbor UCLA Med Ctr, Lundquist Inst, Torrance, CA USA.
   [Garvey, W. Timothy] Univ Alabama Birmingham, Birmingham, AL USA.
   [Hirsch, Irl B.] Univ Washington, Seattle, WA USA.
   [Hurley, Daniel L.; Vellanki, Priyathama] Mayo Clin, Rochester, MN USA.
   [Izuora, Kenneth] Univ Nevadae Las Vegas, Las Vegas, NV USA.
   [Kosiborod, Mikhail] St Lukes Mid Amer Heart Inst, Kansas City, MO USA.
   [Olson, Darin] Colorado Mt Med LLC, Avon, CO USA.
   [Patel, Shailendra B.] Univ Cincinnati, Med Ctr, Cincinnati, OH USA.
   [Sadhu, Archana R.] Houston Methodist, Houston, TX USA.
   [Sadhu, Archana R.] Weill Cornell Med, Houston, TX USA.
   [Sadhu, Archana R.] Texas A&M Coll Med, Houston, TX USA.
   [Samson, Susan L.] Mayo Clin, Jacksonville, FL USA.
   [Stec, Carla] Amer Assoc Clin Endocrinol, Jacksonville, FL USA.
   [Tamborlane, William V., Jr.] Yale Sch Med, New Haven, CT USA.
   [Tuttle, Katherine R.] Univ Washington, Seattle, WA USA.
   [Tuttle, Katherine R.] Providence Hlth Care, Seattle, WA USA.
   [Tuttle, Katherine R.] Providence Hlth Care, Spokane, WA USA.
   [Twining, Christine] Maine Med Ctr, Scarborough, ME USA.
   [Weber, Sandra L.] Univ South Carolina, Sch Med Greenville, Prisma Hlth Syst, Greenville, SC USA.
C3 Emory University; Central Michigan University; Washington University
   (WUSTL); State University of New York (SUNY) System; University at
   Buffalo, SUNY; Cedars Sinai Medical Center; University of Texas System;
   University of Texas at San Antonio (UTSA); University of Michigan
   System; University of Michigan; University of California System;
   University of California Los Angeles; University of California Los
   Angeles Medical Center; University of Alabama System; University of
   Alabama Birmingham; University of Washington; University of Washington
   Seattle; Mayo Clinic; Saint Luke's Mid America Heart Institute;
   University System of Ohio; University of Cincinnati; Houston Methodist;
   Texas A&M University System; Texas A&M University College Station; Texas
   A&M Health Science Center; Mayo Clinic; Yale University; University of
   Washington; University of Washington Seattle; Maine Medical Center;
   Greenville Health System
RP Blonde, L (corresponding author), Amer Assoc Clin Endocrinol, 7643 Gate Pkwy,Suite 104-328, Jacksonville, FL 32256 USA.
EM publications@aace.com
RI Garvey, W. Timothy/KVX-9404-2024; Kosiborod, Mikhail/HDO-1541-2022;
   Berga, Sarah/KHT-7239-2024
OI Galindo, Rodolfo/0000-0002-9295-3225; Tuttle,
   Katherine/0000-0002-2235-0103; Garg, Rajesh/0000-0002-7779-1619
FU American Association of Clinical Endocrinology (AACE)
FX This CPG on developing a comprehensive plan for the care of persons with
   diabetes mellitus was developed with financial support from the American
   Association of Clinical Endocrinology (AACE). All members who served on
   this AACE task force completed work on the manuscript electronically and
   met via video conferences. AACE received no outside funding for the
   development of this guideline. Volunteer authors on this task force
   received no remuneration for their participation in development of this
   guideline.
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PA 525 B STREET, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 1530-891X
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PY 2022
VL 28
IS 10
BP 923
EP 1049
DI 10.1016/j.eprac.2022.08.002
PG 127
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA T6WI9
UT WOS:001079364300001
PM 35963508
OA Green Submitted, Green Accepted
HC Y
HP N
DA 2025-06-11
ER

PT J
AU McHugh, C
   Hind, K
   Davey, D
   Wilson, F
AF McHugh, Cliodhna
   Hind, Karen
   Davey, Daniel
   Wilson, Fiona
TI Cardiovascular Health of Retired Field-Based Athletes: A Systematic
   Review and Meta-analysis
SO ORTHOPAEDIC JOURNAL OF SPORTS MEDICINE
LA English
DT Review
DE cardiovascular; heart disease; retired athletes; field-based;
   evidence-based review; risk factors
ID CORONARY-ARTERY CALCIUM; ASSOCIATION TASK-FORCE; HIGH BLOOD-PRESSURE;
   BODY-MASS INDEX; RISK-FACTORS; METABOLIC SYNDROME; SUBCLINICAL
   ATHEROSCLEROSIS; AMERICAN-COLLEGE; EUROPEAN-SOCIETY; FOOTBALL PLAYERS
AB Background: Retirement from elite sport participation is associated with decreased physical activity, depression, obesity, and ischemic heart disease. Although engagement in physical activity through sport is recognized as cardioprotective, an estimated one-quarter of deaths in American football players are associated with cardiovascular disease (CVD), predominately in players classified as obese. Purpose: To systematically investigate the cardiovascular health profile of retired field-based athletes. Study Design: Systematic review; Level of evidence, 4. Methods: This review was conducted and reported in accordance with the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines and preregistered with PROSPERO. Four databases (PubMed, CINAHL, Embase, and Web of Science) were systematically searched from inception to October 2018 using MeSH terms and keywords. Inclusion criteria were retired field-based athletes, age >18 years, and at least 1 CVD risk factor according to the European Society of Cardiology and the American Heart Association. Review articles were not included. Control groups were not required for inclusion, but when available, an analysis was included. Eligible articles were extracted using Covidence. Methodological quality was assessed independently by 2 reviewers using the AXIS tool. The accuracy of individual study estimates was analyzed using a random-effects meta-analysis. Results: This review yielded 13 studies. A total of 4350 male retired field-based athletes from 2 sports (football and soccer; age range, 42.2-66 years) were included. Eight studies compared retired athletes with control groups. Retired athletes had elevated systolic blood pressure in 4 of 6 studies; approximately 50% of studies found greater high-density lipoprotein, approximately 80% found lower triglyceride levels, and all studies found greater low-density lipoprotein for retired athletes compared with controls. The prevalence and severity of coronary artery calcium and carotid artery plaque were similar to controls. Retired linemen had double the prevalence of cardiometabolic syndrome compared with nonlinemen. Conclusion: The overall findings were mixed. Inconsistencies in the reporting of CVD risk factors and methodological biases reduced the study quality. Retired athletes had a comparable CVD risk profile with the general population. Retired athletes with an elevated body mass index had an increased prevalence and severity of risk factors. Significant gaps remain in understanding the long-term cardiovascular effects of elite athleticism.
C1 [McHugh, Cliodhna; Wilson, Fiona] Trinity Coll Dublin, Sch Med, St Jamess Hosp, Discipline Physiotherapy,Trinity Ctr Hlth Sci, Dublin, Ireland.
   [Hind, Karen; Davey, Daniel] Trinity Coll Dublin, Dublin, Ireland.
   [Hind, Karen] Univ Durham, Dept Sport & Exercise Sci, Durham, England.
   [Davey, Daniel] Univ Coll Dublin, Dublin, Ireland.
C3 Trinity College Dublin; Trinity College Dublin; Durham University;
   University College Dublin
RP McHugh, C (corresponding author), Trinity Coll Dublin, Sch Med, St Jamess Hosp, Trinity Ctr Hlth Sci, Jamess St, Dublin 8, Ireland.
EM cmchugh1@tcd.ie
RI Wilson, Fiona/AAZ-1849-2020; mchugh, cliodhna/GZK-5100-2022; Hind,
   Karen/AAE-6433-2021
OI Wilson, Fiona/0000-0002-0292-1087; McHugh, Cliodhna/0000-0001-9960-1954
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NR 75
TC 19
Z9 19
U1 1
U2 18
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
EI 2325-9671
J9 ORTHOP J SPORTS MED
JI Orthop. J. Sports Med.
PD AUG 19
PY 2019
VL 7
IS 8
AR 2325967119862750
DI 10.1177/2325967119862750
PG 18
WC Orthopedics; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Sport Sciences
GA IR9NJ
UT WOS:000481771500001
PM 31457065
OA Green Published, Green Accepted, gold
DA 2025-06-11
ER

PT J
AU López-Barneo, J
   Ortega-Sáenz, P
   González-Rodríguez, P
   Fernández-Agüra, MC
   Macías, D
   Pardal, R
   Gao, L
AF Lopez-Barneo, Jose
   Ortega-Saenz, Patricia
   Gonzalez-Rodriguez, Patricia
   Carmen Fernandez-Aguera, M.
   Macias, David
   Pardal, Ricardo
   Gao, Lin
TI Oxygen-sensing by arterial chemoreceptors: Mechanisms and medical
   translation
SO MOLECULAR ASPECTS OF MEDICINE
LA English
DT Review
DE Hypoxia; Acute oxygen sensing; Arterial chemoreceptors; Carotid body;
   Adrenal medulla; Oxygen-regulated ion channels; Carotid body stem cells;
   Acclimatization to hypoxia; Pathogenesis of disease
ID RAT CAROTID-BODY; ADRENAL CHROMAFFIN CELLS; NARCOTICS VENTILATORY
   CHEMOSENSITIVITY; HYPOXIC PULMONARY VASOCONSTRICTION; INDUCED
   CATECHOLAMINE SECRETION; NEURAL STEM-CELLS; NEONATAL-RAT; I CELLS;
   GLOMUS CELLS; K+ CHANNELS
AB Acute O-2 sensing is necessary for the activation of cardiorespiratory reflexes (hyperventilation and sympathetic activation), which permit the survival of individuals under hypoxic environments (e.g. high altitude) or medical conditions presenting with reduced capacity for gas exchange between the lung alveoli and the blood. Changes in blood O-2 tension are detected by the arterial chemoreceptors, in particular the carotid body (CB), which act in concert with the adrenal medulla (AM) to facilitate rapid adaptations to hypoxia. The field of arterial chemoreception has undergone a considerable expansion in recent years, with many of the fundamental observations made at the molecular and cellular levels serving to improve our understanding of the pathogenesis of numerous medical disorders, and even to propose advances in the treatment strategies. In this review, after a short historical preface, we describe the current model of chemosensory transduction based on the modulation of membrane K+ channels by O-2 in specialized chemoreceptor cells. Recent progress in elucidating the molecular mechanisms underlying the modulation of ion channels by O-2 tension, which involves mitochondrial complex I, is also discussed. The discovery in the last few years of a specific population of neural crest-derived stem cells in the CB explains the reversible growth of this organ, an intriguing and unusual property of this type of neuronal tissue that contributes to acclimatization under chronic hypoxia. The essential homeostatic role of the CB-AM axis is clearly evident in newly generated mouse models that reach adulthood, albeit with CB and AM atrophy. These animals exhibit a marked intolerance to even mild hypoxia. CB inhibition or over-activation can have important medical consequences. Respiratory depression by general anesthetics or by opioid use is a common clinical condition that frequently causes death in susceptible individuals. An exaggerated sympathetic outflow due to over-activation of the CB-AM axis may contribute to the pathogenesis of several highly prevalent medical conditions, such as chronic heart failure, obstructive sleep apnea, obesity, metabolic syndrome, and diabetes. A detailed understanding of the molecular mechanisms underlying acute O-2 sensing may help in the design of more efficient therapeutic approaches to combat these disorders. (C) 2015 Elsevier Ltd. All rights reserved.
C1 [Lopez-Barneo, Jose; Ortega-Saenz, Patricia; Gonzalez-Rodriguez, Patricia; Carmen Fernandez-Aguera, M.; Macias, David; Pardal, Ricardo; Gao, Lin] Univ Seville, Hosp Univ Virgen del Rocio, Dept Fisiol Med & Biofis, Inst Biomed Sevilla IBiS,CSIC, Seville, Spain.
   [Lopez-Barneo, Jose; Ortega-Saenz, Patricia; Gonzalez-Rodriguez, Patricia; Carmen Fernandez-Aguera, M.; Macias, David; Pardal, Ricardo; Gao, Lin] Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain.
C3 Virgen del Rocio University Hospital; Consejo Superior de
   Investigaciones Cientificas (CSIC); University of Sevilla; CSIC-JA-USE -
   Instituto de Biomedicina de Sevilla (IBIS); CIBERNED
RP López-Barneo, J; Gao, L (corresponding author), Campus Hosp Univ Virgen del Rocio, Inst Biomed Sevilla IBiS, Ave Manuel Siurot S-N, Seville 41013, Spain.
EM lbarneo@us.es; lgao-ibis@us.es
RI Lopez-Barneo, Jose/B-4050-2013; Rodriguez, Patricia/AAV-5006-2020;
   Sáenz, Patricia/E-8623-2016; Pardal, Ricardo/C-4370-2015; Gao,
   Lin/C-8318-2015; Macias, David/AAA-4114-2020
OI Pardal, Ricardo/0000-0003-1085-0714; Gao, Lin/0000-0002-1781-4671;
   Ortega Saenz, Patricia/0000-0003-4962-8483; Fernandez-Aguera Rodriguez,
   Maria del Carmen/0000-0002-0769-213X; Macias, David/0000-0002-8676-1964;
   Gonzalez, Patricia/0000-0002-2561-3984
FU Botin Foundation; Spanish Ministry of Science and Innovation
   [SAF2012-39343]; European Research Council (ERC) [PRJ201502629]
FX The research was supported by grants from the Botin Foundation, Spanish
   Ministry of Science and Innovation (SAF2012-39343), and the European
   Research Council (ERC: PRJ201502629).
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NR 196
TC 50
Z9 54
U1 1
U2 37
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0098-2997
EI 1872-9452
J9 MOL ASPECTS MED
JI Mol. Asp. Med.
PD FEB-MAR
PY 2016
VL 47-48
BP 90
EP 108
DI 10.1016/j.mam.2015.12.002
PG 19
WC Biochemistry & Molecular Biology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Research & Experimental Medicine
GA DD0VH
UT WOS:000369638000008
PM 26709054
DA 2025-06-11
ER

PT J
AU Trovato, E
   Dragotto, M
   Capalbo, E
   Cartocci, A
   Rubegni, P
   Calabrese, L
AF Trovato, Emanuele
   Dragotto, Martina
   Capalbo, Eugenio
   Cartocci, Alessandra
   Rubegni, Pietro
   Calabrese, Laura
TI Risk of Skin Cancer in Patients with Psoriasis: Single-Center
   Retrospective Study Comparing Anti-TNFα and Phototherapy
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Article
DE psoriasis; non-melanoma skin cancers; basal cell carcinoma; squamous
   cell carcinoma; biologic agents; anti-TNF alpha; phototherapy; nb-UVB
ID RHEUMATOID-ARTHRITIS; IMMUNOGENETICS; REGISTRY
AB Background: The risk of developing non-melanoma skin cancers (NMSCs) in patients with psoriasis is highly debated, and, to date, there is no unambiguous consensus opinion. Psoriasis is known to be related to an increased likelihood of other comorbidities such as psoriatic arthritis, obesity, metabolic syndrome, depression, and cardiovascular disease. Regarding cancer risk, previous studies have reported a greater tendency for the development of cutaneous T-lymphomas and colon, breast, kidney, and lung cancers. Furthermore, data from network meta-analyses have shown that patients with psoriasis have a higher risk of developing squamous cell carcinomas (SCCs) and/or basal cell carcinomas (BCCs). Multiple factors may contribute to the development of NMSCs in psoriatic patients, ranging from immunosuppression induced by biologic agents to previous phototherapy. However, the extent to which each factor may impact this risk has not been entirely assessed. The aim of this study was to evaluate the risk of developing NMSCs in patients with psoriasis observed for at least 5 years, by directly comparing patients only treated with phototherapy and patients treated with anti-tumor necrosis factor alpha (TNF alpha) agents, naive to other systemic treatments or phototherapy. Methods: We conducted a single-center retrospective study at Siena University Hospital, Italy, on 200 adult patients with psoriasis divided into two groups: (i) group 1, including 100 patients treated with narrow-band UVB phototherapy (nb-UVB), and (ii) group 2, including 100 patients treated with anti-TNF alpha. The patients included in group 2 had to be naive to cDMARDs and biologics and treated with anti-TNF alpha continuously for 5 years without loss of efficacy. All patients were observed for 5 years and underwent annual dermatologic examinations to assess for the occurrence of BCC or SCC. Results: A total of 34 out of 100 patients treated with phototherapy had one BCC or one SCC and 10 out of 34 developed two skin cancers. In particular, five had both types (one BCC and one SCC), and five had two BCCs. Conclusions: The results of our study highlight how the risk of developing NMSCs is greater in patients undergoing phototherapy compared to those treated with anti-TNF alpha. It also draws attention to the consideration that patients with scalp psoriasis might need closer follow-up as they could be more at risk of developing NMSCs.
C1 [Trovato, Emanuele; Dragotto, Martina; Capalbo, Eugenio; Rubegni, Pietro; Calabrese, Laura] Univ Siena, Dept Med Surg & Neurol Sci, Dermatol Unit, I-53100 Siena, Italy.
   [Cartocci, Alessandra] Univ Siena, Dept Med Biotechnol, I-53100 Siena, Italy.
   [Calabrese, Laura] Univ Cattolica Sacro Cuore, Dipartimento Med & Chirurg Traslazionale, Dermatol, I-00168 Rome, Italy.
C3 University of Siena; University of Siena; Catholic University of the
   Sacred Heart; IRCCS Policlinico Gemelli
RP Calabrese, L (corresponding author), Univ Siena, Dept Med Surg & Neurol Sci, Dermatol Unit, I-53100 Siena, Italy.; Calabrese, L (corresponding author), Univ Cattolica Sacro Cuore, Dipartimento Med & Chirurg Traslazionale, Dermatol, I-00168 Rome, Italy.
EM emanuele.trovato@unisi.it; m.dragotto@student.unisi.it;
   pietro.rubegni@unisi.it; laura.calabrese@unisi.it
RI Calabrese, Laura/HLX-1893-2023; Cartocci, Alessandra/AAB-5831-2020
OI Cartocci, Alessandra/0000-0002-1818-6275; Trovato,
   Emanuele/0000-0001-8301-9206
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NR 40
TC 2
Z9 2
U1 0
U2 7
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD MAY
PY 2024
VL 13
IS 9
AR 2452
DI 10.3390/jcm13092452
PG 11
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA QH1D3
UT WOS:001219886700001
PM 38730981
OA Green Published, gold
DA 2025-06-11
ER

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   Anastasiou, E
   Noctor, E
   de Valk, HW
   van Poppel, MNM
   Agostini, A
   Clarson, C
   Egan, AM
   O'Shea, PM
   Devane, D
   Dunne, FP
AF Bogdanet, Delia
   Reddin, Catriona
   Macken, Esther
   Griffin, Tomas P.
   Fhelelboom, Narjes
   Biesty, Linda
   Thangaratinam, Shakila
   Dempsey, Eugene
   Crowther, Caroline
   Galjaard, Sander
   Maresh, Michael
   Loeken, Mary R.
   Napoli, Angela
   Anastasiou, Eleni
   Noctor, Eoin
   de Valk, Harold W.
   van Poppel, Mireille N. M.
   Agostini, Andrea
   Clarson, Cheril
   Egan, Aoife M.
   O'Shea, Paula M.
   Devane, Declan
   Dunne, Fidelma P.
TI Follow-up at 1 year and beyond of women with gestational diabetes
   treated with insulin and/or oral glucose-lowering agents: a core outcome
   set using a Delphi survey
SO DIABETOLOGIA
LA English
DT Article
DE Core outcome set; Gestational diabetes mellitus; Insulin; Oral
   hypoglycaemic agents
ID PREVALENCE; ASSOCIATION; PREGNANCY; MELLITUS
AB Aims/hypothesis Gestational diabetes mellitus (GDM) is linked with a higher lifetime risk for the development of impaired fasting glucose, impaired glucose tolerance, type 2 diabetes, the metabolic syndrome, cardiovascular disease, postpartum depression and tumours. Despite this, there is no consistency in the long-term follow-up of women with a previous diagnosis of GDM. Further, the outcomes selected and reported in the research involving this population are heterogeneous and lack standardisation. This amplifies the risk of reporting bias and diminishes the likelihood of significant comparisons between studies. The aim of this study is to develop a core outcome set (COS) for RCTs and other studies evaluating the long-term follow-up at 1 year and beyond of women with previous GDM treated with insulin and/oral glucose-lowering agents. Methods The study consisted of three work packages: (1) a systematic review of the outcomes reported in previous RCTs of the follow-up at 1 year and beyond of women with GDM treated with insulin and/or oral glucose-lowering agents; (2) a three-round online Delphi survey with key stakeholders to prioritise these outcomes; and (3) a consensus meeting where the final COS was decided. Results Of 3344 abstracts identified and evaluated, 62 papers were retrieved and 25/62 papers were included in this review. A total of 121 outcomes were identified and included in the Delphi survey. Delphi round 1 was emailed to 835 participants and 288 (34.5%) responded. In round 2, 190 of 288 (65.9%) participants responded and in round 3, 165 of 190 (86.8%) participants responded. In total, nine outcomes were selected and agreed for inclusion in the final COS: assessment of glycaemic status; diagnosis of type 2 diabetes since the index pregnancy; number of pregnancies since the index pregnancy; number of pregnancies with a diagnosis of GDM since the index pregnancy; diagnosis of prediabetes since the index pregnancy; BMI; post-pregnancy weight retention; resting blood pressure; and breastfeeding. Conclusions/interpretation This study identified a COS that will help bring consistency and uniformity to outcome selection and reporting in clinical trials and other studies involving the follow-up at 1 year and beyond of women diagnosed with GDM treated with insulin and/or oral glucose-lowering agents during pregnancy.
C1 [Bogdanet, Delia; Reddin, Catriona; Macken, Esther; Griffin, Tomas P.; Fhelelboom, Narjes; Biesty, Linda; O'Shea, Paula M.; Devane, Declan; Dunne, Fidelma P.] Natl Univ Ireland, Coll Med Nursing & Hlth Sci, Univ Rd, Galway H91 TK33, Ireland.
   [Thangaratinam, Shakila] Queen Mary Univ London, Womens Hlth Res Unit, London, England.
   [Dempsey, Eugene] Univ Coll Cork, INFANT Ctr, Cork, Ireland.
   [Dempsey, Eugene] Univ Coll Cork, Dept Paediat & Child Hlth, Cork, Ireland.
   [Crowther, Caroline] Univ Auckland, Liggins Inst, Auckland, New Zealand.
   [Galjaard, Sander] Univ Med Ctr Rotterdam, Erasmus MC, Dept Obstet & Gynaecol, Div Obstet & Prenatal Med, Gravendijkwal 230, NL-3015 CE Rotterdam, Netherlands.
   [Maresh, Michael] Manchester Univ Hosp NHS Fdn Trust, Manchester Acad Hlth Sci Ctr, St Marys Hosp, Dept Obstet, Manchester, Lancs, England.
   [Loeken, Mary R.] Joslin Diabet Ctr, Sect Islet Cell & Regenerat Biol, Boston, MA 02215 USA.
   [Loeken, Mary R.] Harvard Med Sch, Dept Med, Boston, MA 02115 USA.
   [Napoli, Angela] Sapienza Univ Rome, St Andrea Univ Hosp, Dept Clin & Mol Med, Rome, Italy.
   [Anastasiou, Eleni] Alexandra Hosp, Metab & Diabet Ctr, Dept Endocrinol, Athens, Greece.
   [Noctor, Eoin] Univ Hosp Limerick, Dept Endocrinol, Limerick, Ireland.
   [de Valk, Harold W.] Univ Med Ctr Utrecht, Dept Internal Med, Utrecht, Netherlands.
   [van Poppel, Mireille N. M.] Karl Franzens Univ Graz, Inst Sport Sci, Graz, Austria.
   [Agostini, Andrea] ASL Viterbo Dist A, Consultorio Montefiascone, Rome, Italy.
   [Clarson, Cheril] Univ Western Ontario, Dept Pediat, London, ON, Canada.
   [Clarson, Cheril] Lawson Hlth Res Inst, London, ON, Canada.
   [Egan, Aoife M.] Mayo Clin, Div Endocrinol Diabet & Metab, Rochester, MN USA.
C3 University of London; Queen Mary University London; University College
   Cork; University College Cork; University of Auckland; Erasmus
   University Rotterdam; Erasmus MC; University of Manchester; Wythenshawe
   Hospital NHS Foundation Trust; Harvard University; Harvard University
   Medical Affiliates; Joslin Diabetes Center, Inc.; Harvard University;
   Harvard Medical School; Sapienza University Rome; Azienda Ospedaliera
   Sant'Andrea; Alexandra Hospital; University of Limerick; Utrecht
   University; Utrecht University Medical Center; University of Graz;
   Western University (University of Western Ontario); Western University
   (University of Western Ontario); University Western Ontario Hospital;
   Mayo Clinic
RP Bogdanet, D (corresponding author), Natl Univ Ireland, Coll Med Nursing & Hlth Sci, Univ Rd, Galway H91 TK33, Ireland.; Galjaard, S (corresponding author), Univ Med Ctr Rotterdam, Erasmus MC, Dept Obstet & Gynaecol, Div Obstet & Prenatal Med, Gravendijkwal 230, NL-3015 CE Rotterdam, Netherlands.
EM deliabogdanet@gmail.com; s.galjaard@erasmusmc.nl
RI Bogdanet, Delia/R-8263-2017; Napoli, Angela/AAN-2409-2020; O'Shea,
   Paula/JFB-1706-2023; Thangaratinam, Shakila/AAP-3724-2021; Griffin,
   Tomas Patrick/HRA-1241-2023; Dempsey, Eugene/AAG-3037-2021; Loeken,
   Mary/AAC-2450-2022; Van Poppel, Mireille/AAL-8228-2020; Dempsey, Eugene
   Michael/H-8051-2015; Devane, Declan/B-8357-2008
OI Biesty, Linda/0000-0002-1108-1518; Reddin, Catriona/0000-0002-6396-5913;
   Dempsey, Eugene Michael/0000-0002-6266-3462; Bogdanet,
   Delia/0000-0001-6127-5049; Noctor, Eoin/0000-0002-8173-4289; Loeken,
   Mary/0000-0002-8056-9816; O'Shea, Paula/0000-0001-9392-1711; Dunne,
   Fidelma/0000-0003-3682-9403; Thangaratinam, Shakila/0000-0002-4254-460X;
   Devane, Declan/0000-0002-9393-7075
FU HRB-Trials Methodology Research Network; Hardiman Scholarship from the
   College of Medicine, Nursing and Health Science, National University of
   Ireland, Galway, Ireland; Irish Endocrine Society/Royal College of
   Physicians of Ireland
FX The HRB-Trials Methodology Research Network part funded the consensus
   meeting. TPG is supported by a Hardiman Scholarship from the College of
   Medicine, Nursing and Health Science, National University of Ireland,
   Galway, Ireland, and a bursary from the Irish Endocrine Society/Royal
   College of Physicians of Ireland.
CR [Anonymous], 2015, DIABETES CARE, V38, pS77, DOI 10.2337/dc15-S015
   [Anonymous], 1969, DELPHI METHOD EXPT S
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NR 25
TC 20
Z9 23
U1 0
U2 3
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0012-186X
EI 1432-0428
J9 DIABETOLOGIA
JI Diabetologia
PD NOV
PY 2019
VL 62
IS 11
BP 2007
EP 2016
DI 10.1007/s00125-019-4935-9
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA JG2ZU
UT WOS:000491944900006
PM 31273408
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Bener, A
   Abdulmalik, M
   Al-Kazaz, M
   Sanya, R
   Buhmaid, S
   Al-Harthy, M
   Mohammad, AG
AF Bener, Abdulbari
   Abdulmalik, Mariam
   Al-Kazaz, Mohammed
   Sanya, Rahima
   Buhmaid, Sara
   Al-Harthy, Munjid
   Mohammad, Abdul-Ghani
TI Does good clinical practice at the primary care improve the outcome care
   for diabetic patients? Gender differences
SO PRIMARY CARE DIABETES
LA English
DT Article
DE Audit; Evaluation; HbA1c; Gender; Treatment; Intervention; Primary care
ID CORONARY-HEART-DISEASE; METABOLIC SYNDROME; TREATMENT SATISFACTION;
   MEDICATION ADHERENCE; LIFE-STYLE; DEPRESSION; MELLITUS; PREVALENCE;
   PEOPLE; HEALTH
AB Background: The Middle East region is predicted to have one of the highest prevalence of diabetes mellitus (DM) in the world. This is the first study in the region to assess treatment outcome of DM according to gender.
   Objective: To assess the quality and effectiveness of diabetes care provided to patients attending primary care settings according to gender in the State of Qatar.
   Design: It is an observational cohort study.
   Setting: The survey was carried out in primary health care (PHC) centers in the State of Qatar.
   Subjects and methods: The study was conducted from January 2010 to August 2010 among diabetic patients attending (PHC) centers. Of the 2334 registered with diagnosed diabetes, 1705 agreed and gave their consent to take part in this study, thus giving a response rate of 73.1%. Face to face interviews were conducted using a structured questionnaire including socio-demographic, clinical and satisfaction score of the patients.
   Results: Majority of subjects were diagnosed with type 2 DM (84.9%). A significantly larger proportion of females with DM were divorced or widowed (9.1%) in comparison to males with DM (3.4%; p < 0.001). A significantly larger proportion of females were overweight (46.5%; p = 0.009) and obese (29.5%; p = 0.003) in comparison to males. Males reported significantly greater improvements in mean values of blood glucose (mmol/l) (-2.11 vs. -0.66; p = 0.007), HbA1c (%) (-1.44 vs. -0.25; p = 0.006), cholesterol (mmol/l) (-0.16 vs. 0.12; p = 0.053) and systolic blood pressure (mmHg) (-9.04 vs. -6.62; p < 0.001) in comparison to females. While there was a remarkable increase in male patients with normal range of fasting blood glucose (FBG; 51.6%) as compared to the FBG measurement 1 year before (28.5%: p < 0.001) there was only a slight increase in females normal range FBG during this period from 28.0% to 30.4% (p = 0.357).
   Conclusion: The present study revealed that the current form of PHC centers afforded to diabetic patients provided significantly improved outcomes for males, but only minor improved outcomes for females. This study reinforces calls for a gender-specific approach to diabetes care. (C) 2012 Primary Care Diabetes Europe. Published by Elsevier Ltd. All rights reserved.
C1 [Bener, Abdulbari] Hamad Med Corp, Dept Med Stat & Epidemiol, Hamad Gen Hosp, Doha, Qatar.
   [Bener, Abdulbari] Univ Manchester, Sch Epidemiol & Hlth Sci, Dept Evidence Populat Hlth Unit, Manchester, Lancs, England.
   [Bener, Abdulbari; Al-Kazaz, Mohammed; Sanya, Rahima; Buhmaid, Sara] Weill Cornell Med Coll, Dept Publ Hlth, Doha, Qatar.
   [Bener, Abdulbari; Al-Kazaz, Mohammed; Sanya, Rahima; Buhmaid, Sara] Weill Cornell Med Coll, Dept Med Educ, Doha, Qatar.
   [Mohammad, Abdul-Ghani] Univ Texas Hlth Sci Ctr San Antonio, Div Diabet, San Antonio, TX 78229 USA.
C3 Hamad Medical Corporation; Hamad General Hospital; University of
   Manchester; Qatar Foundation (QF); Weill Cornell Medical College Qatar;
   Qatar Foundation (QF); Weill Cornell Medical College Qatar; University
   of Texas System; University of Texas Health Science Center at San
   Antonio
RP Bener, A (corresponding author), Hamad Med Corp, Dept Med Stat & Epidemiol, Hamad Gen Hosp, POB 3050, Doha, Qatar.
EM abener@hmc.org.qa
RI Al-Kazaz, Mohamed/LOR-3276-2024; BENER, ABDULBARİ/AAC-4436-2020
OI Al-Kazaz, Mohamed/0009-0003-9357-0175
FU Qatar Foundation [UREP 07-099-3-023]; Hamad Medical Corporation
FX This work was generously supported and funded by the Qatar Foundation
   Grant No. UREP 07-099-3-023. The authors would like to thank the Hamad
   Medical Corporation for their support and ethical approval. The authors
   would also like to thank Mariam Abdel-Hafiz for preparation and editing
   of the manuscript.
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NR 38
TC 9
Z9 11
U1 0
U2 12
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1751-9918
EI 1878-0210
J9 PRIM CARE DIABETES
JI Prim. Care Diabetes
PD DEC
PY 2012
VL 6
IS 4
BP 285
EP 292
DI 10.1016/j.pcd.2012.04.007
PG 8
WC Endocrinology & Metabolism; Primary Health Care
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; General & Internal Medicine
GA 052XD
UT WOS:000312232800006
PM 22622594
DA 2025-06-11
ER

PT J
AU Shoaib, M
   Zia, MQ
   Latif, A
   Ansar, A
   Liaqat, I
AF Shoaib, Muhammad
   Zia, Muhammad Qasim
   Latif, Ansar
   Ansar, Anila
   Liaqat, Ibrahim
TI Diabetes Type 2; Correlation of Magnesium Levels in managing the
   patients - A cohort study at Khawaja Safdar Medical College, Sialkot
SO PAKISTAN JOURNAL OF MEDICAL & HEALTH SCIENCES
LA English
DT Article
DE Aging; Endothelium Hypertension; Inflammation; Insulin resistance;
   Magnesium; Metabolic syndrome
ID LOW SERUM MAGNESIUM; SUPPLEMENTATION; HYPOMAGNESEMIA; DEPRESSION;
   SULFATE; PLACEBO; INSULIN; RISK
AB Aim: To evaluate and monitor Magnesium levels in the management of patients with Diabetes type 2 at Khawaja Muhammad Safdar Medical College, Sialkot
   Study Design: Prospective Study
   Place and Duration of Study: Departments of Physiology and Medicine, Khawaja Muhammad Safdar Medical College, Sialkot from June 2016 to May June 2020.
   Methodology: The diabetic (type 2) were patients included in this study were managed at treated and followed in Department of Physiology and Department of Medicine, Khawaja Muhammad Safdar Medical college. Sialkot. Written consent was taken from the patients before including them in the study conducted. All patients reporting to medical OPD 2000 type-II diabetes during the study duration were included. These patients were divided into three groups according to their HbA1c levels. First group (Group I) included 1100 subjects who had borderline HBA1c (5.7-6.4%) with good control of diabetes on oral hypoglycemic agents, (Group II) 500 subjects had moderately high HBA1c (6.5%-7.4%) and poorly controlled diabetes with oral hypoglycemic agents while (Group III) 400 subjects had very high HBA1c (>= 7.5%) levels and very poor control of diabetes and these patients were also admitted in the hospital to control hyperglycemia.
   Results: Total 2234 patients were enrolled in this study. 234 lost to follow up and they were excluded from the study. 2000 subjects included in the study. Age range of subjects was 17-89years with mean age of 46 +/- 9.7(S.D) years. Male to females (622:1378) ratio was 1:2.21. Total duration of diabetes diagnosis in these patients ranged from 1-15 years with mean age 9 +/- 4.5(S.D) years. Total 7883 blood complete picture and 7883 serum magnesium tests were performed. Total 3451 fasting plasma glucose tests and 3900 glycosylated hemoglobin (HbA1c)% tests were carried out. Follow up duration was ranged from 3 months to 15 months with mean duration of 5 +/- 3.11(S.D) months. Subjects were divided into three groups according to their fasting glucose and HbA1c levels. Group I (n=1100) had diabetes with good control, Group II (n=500) included diabetics with poor control while Group III (n=400) were uncontrolled diabetics.
   Conclusion: Low Magnesium levels have a strong relation in poor glycaemic control in patients with Type 2 Diabetes. The laboratory investigations including Serum Mg levels can guide better in management of such patients.
C1 [Shoaib, Muhammad] Safdar Med Coll, Dept Physiol, Sialkot, Pakistan.
   [Zia, Muhammad Qasim] Khawaja Muhammad Safdar Med Coll, Dept Gastroenterol, Sialkot, Pakistan.
   [Latif, Ansar] Khawaja Safdar Med Coll, Surg Dept, Sialkot, Pakistan.
   [Ansar, Anila] Khawaja Safdar Med Coll, Gynae Dept, Sialkot, Pakistan.
   [Liaqat, Ibrahim] Khawaja Muhammad Safdar Med Coll, Dept Physiol, Sialkot, Pakistan.
RP Shoaib, M (corresponding author), Safdar Med Coll, Dept Physiol, Sialkot, Pakistan.
EM drshoaib11@yahoo.com
RI Munir, Muhammad/T-4965-2019
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   Yu L, 2017, BLOOD PURIFICAT, V43, P31, DOI 10.1159/000451052
NR 26
TC 0
Z9 0
U1 0
U2 0
PU LAHORE MEDICAL & DENTAL COLL
PI Lahore
PA Tulspura, North Canal Bank, Lahore, PAKISTAN
SN 1996-7195
J9 PAK J MED HLTH SCI
JI Pakistan J. Med. Hlth. Sci.
PD JAN
PY 2021
VL 15
IS 1
BP 19
EP 22
PG 4
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA RC1VN
UT WOS:000632592200006
DA 2025-06-11
ER

PT J
AU Gong, W
   Lin, H
   Ma, XT
   Ma, HL
   Lan, YL
   Sun, P
   Yang, JJ
AF Gong, Wei
   Lin, Hong
   Ma, Xiuting
   Ma, Hongliang
   Lan, Yali
   Sun, Peng
   Yang, Jianjun
TI The regional disparities in liver disease comorbidity among elderly
   Chinese based on a health ecological model: the China Health and
   Retirement Longitudinal Study
SO BMC PUBLIC HEALTH
LA English
DT Article
DE Liver disease comorbidity; Elderly people; Co-morbid co-causal pattern;
   Association rules; Geographic information system
ID MULTIMORBIDITY PATTERNS; COMPLEX INTERRELATIONSHIPS; METABOLIC SYNDROME;
   DEPRESSION; PREVALENCE; POPULATION; REGRESSION; MORTALITY; KIDNEY;
   ADULTS
AB Purpose This study aimed to investigate the risk factors for liver disease comorbidity among older adults in eastern, central, and western China, and explored binary, ternary and quaternary co-morbid co-causal patterns of liver disease within a health ecological model.Method Basic information from 9,763 older adults was analyzed using data from the China Health and Retirement Longitudinal Study (CHARLS). LASSO regression was employed to identify significant predictors in eastern, central, and western China. Patterns of liver disease comorbidity were studied using association rules, and spatial distribution was analyzed using a geographic information system. Furthermore, binary, ternary, and quaternary network diagrams were constructed to illustrate the relationships between liver disease comorbidity and co-causes.Results Among the 9,763 elderly adults studied, 536 were found to have liver disease comorbidity, with binary or ternary comorbidity being the most prevalent. Provinces with a high prevalence of liver disease comorbidity were primarily concentrated in Inner Mongolia, Sichuan, and Henan. The most common comorbidity patterns identified were "liver-heart-metabolic", "liver-kidney", "liver-lung", and "liver-stomach-arthritic". In the eastern region, important combination patterns included "liver disease-metabolic disease", "liver disease-stomach disease", and "liver disease-arthritis", with the main influencing factors being sleep duration of less than 6 h, frequent drinking, female, and daily activity capability. In the central region, common combination patterns included "liver disease-heart disease", "liver disease-metabolic disease", and "liver disease-kidney disease", with the main influencing factors being an education level of primary school or below, marriage, having medical insurance, exercise, and no disabilities. In the western region, the main comorbidity patterns were "liver disease-chronic lung disease", "liver disease-stomach disease", "liver disease-heart disease", and "liver disease-arthritis", with the main influencing factors being general or poor health satisfaction, general or poor health condition, severe pain, and no disabilities.Conclusion The comorbidities associated with liver disease exhibit specific clustering patterns at both the overall and local levels. By analyzing the comorbidity patterns of liver diseases in different regions and establishing co-morbid co-causal patterns, this study offers a new perspective and scientific basis for the prevention and treatment of liver diseases.
C1 [Gong, Wei; Lin, Hong; Ma, Xiuting; Lan, Yali; Sun, Peng; Yang, Jianjun] Ningxia Med Univ, Publ Hlth Sch, Yinchuan 750004, Peoples R China.
   [Gong, Wei; Lin, Hong; Sun, Peng; Yang, Jianjun] Key Lab Environm Factors & Chron Dis Control, Yinchuan 750004, Peoples R China.
   [Gong, Wei] Ningxia Med Univ, Sch Med Informat & Engn, Yinchuan 750004, Peoples R China.
   [Ma, Hongliang] Ningxia Med Univ, Sch Clin Med, Yinchuan 750004, Peoples R China.
   [Sun, Peng] Ningxia Med Univ, Res Ctr Med Sci & Technol, Yinchuan 750004, Peoples R China.
   [Sun, Peng] Ningxia Inst Med Sci, Yinchuan 750004, Peoples R China.
C3 Ningxia Medical University; Ningxia Medical University; Ningxia Medical
   University; Ningxia Medical University
RP Sun, P; Yang, JJ (corresponding author), Ningxia Med Univ, Publ Hlth Sch, Yinchuan 750004, Peoples R China.; Sun, P; Yang, JJ (corresponding author), Key Lab Environm Factors & Chron Dis Control, Yinchuan 750004, Peoples R China.; Sun, P (corresponding author), Ningxia Med Univ, Res Ctr Med Sci & Technol, Yinchuan 750004, Peoples R China.; Sun, P (corresponding author), Ningxia Inst Med Sci, Yinchuan 750004, Peoples R China.
EM preston.sunpeng@gmail.com; yangjj@nxmu.edu.cn
RI Ma, Hongliang/Z-2638-2019
FU Scientific research project of Ningxia Medical University in 2020
FX We would like to express our sincere gratitude to Peking University for
   providing data of CHARLS and to those involved in data collection and
   management.
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NR 69
TC 1
Z9 1
U1 24
U2 45
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2458
J9 BMC PUBLIC HEALTH
JI BMC Public Health
PD APR 23
PY 2024
VL 24
IS 1
AR 1123
DI 10.1186/s12889-024-18494-x
PG 20
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA OK8Y7
UT WOS:001207269400004
PM 38654168
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Giugliano, F
   Maiorino, MI
   Di Palo, C
   Autorino, R
   De Sio, M
   Giugliano, D
   Esposito, K
AF Giugliano, Francesco
   Maiorino, Maria Ida
   Di Palo, Carmen
   Autorino, Riccardo
   De Sio, Marco
   Giugliano, Dario
   Esposito, Katherine
TI Adherence to Mediterranean Diet and Sexual Function in Women with Type 2
   Diabetes
SO JOURNAL OF SEXUAL MEDICINE
LA English
DT Article
DE Mediterranean Diet; Female Sexual Dysfunction; Type 2 Diabetes
ID FUNCTION INDEX FSFI; ERECTILE DYSFUNCTION; RISK-FACTORS; PREVALENCE;
   INFLAMMATION; EMPHASIS; FIBER; LIFE
AB Introduction.
   There are no reported studies assessing the relation between diet and sexual function in women with diabetes.
   Aim.
   In the present study, we explored the relation between consumption of a Mediterranean-type diet and sexual function in a population of type 2 diabetic women.
   Methods.
   Patients with type 2 diabetes were enrolled if they had a diagnosis of type 2 diabetes for at least six months but less than 10 years, age 35-70 years, body mass index (BMI) of 24 or higher, HbA1c of 6.5% or higher, treatment with diet or oral drugs. All diabetic patients were invited to complete a food-frequency questionnaire and self-report measures of sexual function. A total of 595 (90.2%) of the 659 women completed both questionnaires and were analyzed in the present study.
   Main Outcome Measures.
   Adherence to a Mediterranean diet was assessed by a 9-point scale that incorporated the salient characteristics of this diet (range of scores, 0-9, with higher scores indicating greater adherence). The Female Sexual Function Index (FSFI) was used for assessing the key dimensions of female sexual function.
   Results.
   Diabetic women with the highest scores (6-9) had lower BMI, waist circumference, and waist-to-hip ratio, a lower prevalence of depression, obesity and metabolic syndrome, a higher level of physical activity, and better glucose and lipid profiles than the diabetic women who scored < 3 points on the scale. The proportion of sexually active women showed a significant increase across tertiles of adherence to Mediterranean diet (from 54.2% to 65.1%, P = 0.01). Based on the FSFI cutoff score for female sexual dysfunction (FSD) of 23, women with the highest score of adherence had a lower prevalence of sexual dysfunction as compared with women of lower tertiles (47.6%, 53.9%, and 57.8%, higher, middle, and lower tertile, respectively, P = 0.01). These associations remained significant after adjustment for many potential confounders.
   Conclusions.
   In women with type 2 diabetes, greater adherence to Mediterranean diet is associated with a lower prevalence of FSD. Giugliano F, Maiorino MI, Di Palo C, Autorino R, De Sio M, Giugliano D, and Esposito K. Adherence to mediterranean diet and sexual function in women with type 2 diabetes. J Sex Med 2010;7:1883-1890.
C1 [Esposito, Katherine] Univ Naples 2, Dept Geriatr & Metab Dis, Chair Diabetol & Metab Dis, Div Diabetol & Metab Dis, I-80138 Naples, Italy.
   [Giugliano, Francesco; Autorino, Riccardo; De Sio, Marco] Univ Naples 2, Dept Geriatr & Metab Dis, Div Urol, I-80138 Naples, Italy.
C3 Universita della Campania Vanvitelli; Universita della Campania
   Vanvitelli
RP Esposito, K (corresponding author), Univ Naples 2, Dept Geriatr & Metab Dis, Chair Diabetol & Metab Dis, Div Diabetol & Metab Dis, I-80138 Naples, Italy.
EM katherine.esposito@unina2.it
RI Autorino, Riccardo/AAJ-7994-2020; Maiorino, Maria Ida/AHE-9986-2022;
   Esposito, Katherine/AHE-2564-2022; De Sio, Marco/AAA-6330-2021;
   Maiorino, Maria Ida/K-3264-2016
OI De Sio, Marco/0000-0003-0820-6030; Maiorino, Maria
   Ida/0000-0003-4659-7546; Giugliano, Dario/0000-0002-9377-873X
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NR 40
TC 43
Z9 44
U1 0
U2 11
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1743-6095
EI 1743-6109
J9 J SEX MED
JI J. Sex. Med.
PD MAY
PY 2010
VL 7
IS 5
BP 1883
EP 1890
DI 10.1111/j.1743-6109.2010.01714.x
PG 8
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 587PI
UT WOS:000277004400022
PM 20214715
DA 2025-06-11
ER

PT J
AU Hartley, L
   Dyakova, M
   Holmes, J
   Clarke, A
   Lee, MS
   Ernst, E
   Rees, K
AF Hartley, Louise
   Dyakova, Mariana
   Holmes, Jennifer
   Clarke, Aileen
   Lee, Myeong Soo
   Ernst, Edzard
   Rees, Karen
TI Yoga for the primary prevention of cardiovascular disease
SO COCHRANE DATABASE OF SYSTEMATIC REVIEWS
LA English
DT Review
ID METABOLIC SYNDROME; STRESS REDUCTION; HATHA-YOGA; EXERCISE; ADULTS;
   INTERVENTION; METAANALYSIS; PUBLICATION; PREVALENCE; WOMEN
AB Background
   A sedentary lifestyle and stress are major risk factors for cardiovascular disease (CVD). Since yoga involves exercise and is thought to help in stress reduction it may be an effective strategy in the primary prevention of CVD.
   Objectives
   To determine the effect of any type of yoga on the primary prevention of CVD.
   Search methods
   We searched the following electronic databases: the Cochrane Central Register of Controlled Trials (CENTRAL) (2013, Issue 11) in The Cochrane Library; MEDLINE (Ovid) (1946 to November Week 3 2013); EMBASE Classic + EMBASE (Ovid) (1947 to 2013 Week 48); Web of Science (Thomson Reuters) (1970 to 4 December 2013); Database of Abstracts of Reviews of Effects (DARE), Health Technology Assessment Database and Health Economics Evaluations Database (Issue 4 of 4, 2013) in The Cochrane Library. We also searched a number of Asian databases and the Allied and Complementary Medicine Database (AMED) (inception to December 2012). We searched trial registers and reference lists of reviews and articles, and approached experts in the field. We applied no language restrictions.
   Selection criteria
   Randomised controlled trials lasting at least three months involving healthy adults or those at high risk of CVD. Trials examined any type of yoga and the comparison group was no intervention or minimal intervention. Outcomes of interest were clinical CVD events and major CVD risk factors. We did not include any trials that involved multifactorial lifestyle interventions or weight loss.
   Data collection and analysis
   Two authors independently selected trials for inclusion, extracted data and assessed the risk of bias.
   Main results
   We identified 11 trials (800 participants) and two ongoing studies. Style and duration of yoga differed between trials. Half of the participants recruited to the studies were at high risk of CVD. Most of studies were at risk of performance bias, with inadequate details reported in many of them to judge the risk of selection bias.
   No study reported cardiovascular mortality, all-cause mortality or non-fatal events, and most studies were small and short-term. There was substantial heterogeneity between studies making it impossible to combine studies statistically for systolic blood pressure and total cholesterol. Yoga was found to produce reductions in diastolic blood pressure (mean difference (MD) -2.90 mmHg, 95% confidence interval (CI) -4.52 to -1.28), which was stable on sensitivity analysis, triglycerides (MD -0.27 mmol/l, 95% CI -0.44 to -0.11) and high-density lipoprotein (HDL) cholesterol (MD 0.08 mmol/l, 95% CI 0.02 to 0.14). However, the contributing studies were small, short-term and at unclear or high risk of bias. There was no clear evidence of a difference between groups for low-density lipoprotein (LDL) cholesterol (MD -0.09 mmol/l, 95% CI -0.48 to 0.30), although there was moderate statistical heterogeneity. Adverse events, occurrence of type 2 diabetes and costs were not reported in any of the included studies. Quality of life was measured in three trials but the results were inconclusive.
   Authors' conclusions
   The limited evidence comes from small, short-term, low-quality studies. There is some evidence that yoga has favourable effects on diastolic blood pressure, HDL cholesterol and triglycerides, and uncertain effects on LDL cholesterol. These results should be considered as exploratory and interpreted with caution.
C1 [Hartley, Louise; Dyakova, Mariana; Clarke, Aileen; Rees, Karen] Univ Warwick, Warwick Med Sch, Div Hlth Sci, Coventry CV4 7AL, Warwick, England.
   [Holmes, Jennifer] Univ Warwick, Warwick Med Sch, Coventry CV4 7AL, Warwick, England.
   [Lee, Myeong Soo] Korea Inst Oriental Med, Med Res Div, Taejon, South Korea.
   [Ernst, Edzard] Univ Exeter, Peninsula Med Sch, Complementary Med Dept, Exeter, Devon, England.
C3 University of Warwick; University of Warwick; Korea Institute of
   Oriental Medicine (KIOM); University of Exeter
RP Rees, K (corresponding author), Univ Warwick, Warwick Med Sch, Div Hlth Sci, Coventry CV4 7AL, Warwick, England.
EM Karen.Rees@warwick.ac.uk
RI Lee, Myeong Soo/C-8147-2013; Clarke, Aileen/I-5679-2012
OI Clarke, Aileen/0000-0001-8299-3146; Rees, Karen/0000-0003-1832-3679
FU Warwick Medical School, University of Warwick, UK; NIHR Cochrane
   Programme Grant, UK; National Institute for Health Research (NIHR)
   Collaboration for Leadership in Applied Health Research and Care West
   Midlands at University Hospitals Birmingham NHS Foundation Trust, UK
FX Internal sources Warwick Medical School, University of Warwick, UK.
   External sources NIHR Cochrane Programme Grant, UK. Karen Rees is also
   supported by the National Institute for Health Research (NIHR)
   Collaboration for Leadership in Applied Health Research and Care West
   Midlands at University Hospitals Birmingham NHS Foundation Trust, UK.
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NR 74
TC 48
Z9 55
U1 0
U2 30
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1469-493X
EI 1361-6137
J9 COCHRANE DB SYST REV
JI Cochrane Database Syst Rev.
PY 2014
IS 5
AR CD010072
DI 10.1002/14651858.CD010072.pub2
PG 51
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA AI2AD
UT WOS:000336657000030
PM 24825181
OA Green Published
DA 2025-06-11
ER

PT J
AU Yu, JC
   Deng, YL
   Tao, ZW
   Liang, WX
   Guan, XF
   Wu, JH
   Ning, X
   Liu, YL
   Liu, Q
   He, ZQ
AF Yu, Junchuan
   Deng, Yaoliang
   Tao, Zhiwei
   Liang, Weixia
   Guan, Xiaofeng
   Wu, Jihua
   Ning, Xin
   Liu, Yunlong
   Liu, Quan
   He, Ziqi
TI The effects of HAP and macrophage cells to the expression of
   inflammatory factors and apoptosis in HK-2 cells of vitro co-cultured
   system
SO UROLITHIASIS
LA English
DT Article
DE Macrophage cells; Hydroxyapatite; Renal tubular epithelial cells;
   Co-culture; Fetuin-A
ID KIDNEY-STONE FORMATION; RENAL TUBULAR CELLS; CALCIUM-OXALATE
   NEPHROLITHIASIS; METABOLIC SYNDROME; OXIDATIVE STRESS; EPITHELIAL-CELLS;
   DIHYDRATE CRYSTALS; RANDALLS PLAQUE; RAT MODEL; IN-VITRO
AB This study developed an in vitro system by co-culturing HK-2 cells with different concentration of hydroxyapatite (HAP) and/or macrophage cells to simulate the internal environment of urolithiasis as far as possible, investigating the regulatory effects of macrophage cells on HAP-induced expression of relative inflammatory factors of HK-2 cells. The control group (H group) was only comprised of HK-2 cells. Experimental groups included co-culturing HK-2 cells and macrophage cells (H + M group), co-culturing HK-2 cells and HAP (H + A group), co-culturing macrophage cells and HAP (M + A group), and co-culturing HK-2 cells and macrophage cells with HAP (H + M + A group). In the H + A, M + A, and H + M + A group, we set the concentration of HAP as 5 mu g/cm(2) (A1) and 10 mu g/cm(2) (A2). After co-culturing for 2, 4, and 6 h, we detected the expression of CCL-2 in the liquid by ELISA. We tested the expression of LDH and ROS to evaluate the damage of HK-2 cells. We assessed the apoptosis of HK-2 cells using DAPI staining assay, flow cytometry, and the rate of BAX/BCL-2. Western Blotting detected OPN, Fetuin-A, BAX, and BCL-2 of HK-2 cells. The expression of CCL-2 in the medium of H + A1 and H + A2 group increased significantly compared with the control (P < 0.05); CCL-2 of M + A1 and M + A2 group was higher than the H + A1 and H + A2 group (P < 0.05). The expression of CCL-2 in H + M + A1 and H + M + A2 group was also higher than M + A1 and M + A2 group (P < 0.05). Compared with control, the expression of OPN, LDH release, the ratio of BAX/BCL-2, and the generation of ROS in HK-2 cells increased in a dose- and time-dependent manner. Compared with the control, the expression of Fetuin-A decreased in various degrees at different incubation periods. Especially when co-culturing for 6 h, Fetuin-A decreased most seriously in the H + M + A1 group. (1) The HAP can induce the HK-2 cells oxidative stress and inflammatory damage and apoptosis, when adding the macrophages to co-culture, macrophage cells can aggravate the damage and apoptosis of the HK-2 cells. (2) After the stimulation of HAP, the expression of OPN in HK-2 cells increased in a time- and dose-dependent manner; macrophage cells can aggravate the increase of OPN in HK-2 cells. (3) In the HAP and HK-2 cells co-cultured system, the low-level Fetuin-A of HK-2 cells may be related to the excessive consumption of Fetuin-A in the process of HAP-induced renal tubular epithelial cell excessive oxidative stress, inflammatory injury, and cell apoptosis. When adding macrophage cells to co-culture, Fetuin-A decreased even more seriously, it reminds us that macrophage cells can slightly regulate the expression of Fetuin-A in the HK-2 cells.
C1 [Yu, Junchuan; Deng, Yaoliang; Tao, Zhiwei; Liang, Weixia; Guan, Xiaofeng; Wu, Jihua; Ning, Xin; Liu, Yunlong; Liu, Quan; He, Ziqi] Guangxi Med Univ, Dept Urol, Affiliated Hosp 1, Nanning 530021, Peoples R China.
C3 Guangxi Medical University
RP Deng, YL; Liang, WX (corresponding author), Guangxi Med Univ, Dept Urol, Affiliated Hosp 1, Nanning 530021, Peoples R China.
EM dylkf317@163.com; liangweixia2004@163.com
RI Yu, Junchuan/CAI-0495-2022
OI Deng deng, Yaoliang yao liang/0000-0003-3265-7835
FU National Natural Science Foundation of China [81360113, 30860280,
   30960455, 81760127]
FX This study was funded by the National Natural Science Foundation of
   China (No. 81360113, 30860280, 30960455, 81760127).
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NR 63
TC 8
Z9 10
U1 1
U2 14
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 2194-7228
EI 2194-7236
J9 UROLITHIASIS
JI Urolithiasis
PD OCT
PY 2018
VL 46
IS 5
BP 429
EP 443
DI 10.1007/s00240-017-1032-8
PG 15
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA GU6NV
UT WOS:000445433100003
PM 29236151
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Gao, H
   Meng, J
   Xing, H
   Nie, SK
   Xu, MJ
   Zhang, S
   Jin, YL
   Sun, TP
   Huang, H
   Zhang, HW
   Wang, D
   Liu, LG
AF Gao, Hui
   Meng, Jie
   Xing, Hui
   Nie, Shuke
   Xu, Mengjing
   Zhang, Shun
   Jin, Yilin
   Sun, Taoping
   Huang, Hao
   Zhang, Hanwang
   Wang, Di
   Liu, Liegang
TI Association of heme oxygenase-1 with the risk of polycystic ovary
   syndrome in non-obese women
SO HUMAN REPRODUCTION
LA English
DT Article
DE polycystic ovary syndrome; insulin resistance; oxidative stress;
   inflammation; heme oxygenase-1
ID IMPROVES INSULIN SENSITIVITY; OXIDATIVE STRESS; GLUCOSE-TOLERANCE;
   METABOLIC SYNDROME; ADIPOSE-TISSUE; DIABETIC MICE; SYNDROME PCOS;
   RESISTANCE; OBESITY; INFLAMMATION
AB Is circulating heme oxygenase-1 (HO-1) associated with the risk of polycystic ovary syndrome (PCOS)?
   Lower circulating HO-1 is associated with a higher risk of PCOS in non-obese women, in a dose-related manner.
   PCOS is one of the most common endocrine disorders in women of reproductive age, with increasing worldwide incidence. HO-1 plays a crucial role in many physiological systems, with potent anti-inflammatory, antioxidant and antimetabolic properties.
   This hospital-based casecontrol study included 80 women with PCOS and 80 healthy control women seen at the Reproductive Center of Tongji Hospital (Wuhan, China) from November 2011 to May 2012. Cases and controls were frequency-matched on age and BMI and were enrolled into the study once written informed consent had been obtained.
   Serum hormones, glucose, insulin and lipid concentrations were measured using an automated platform. Correlation coefficients and multiple linear regression models were calculated in the combined group (both cases and controls) using serum HO-1 concentration as the independent variable and age and BMI as covariate variables to explore the association between HO-1 and the pathophysiology of PCOS. To examine the independent association of serum HO-1 levels with the likelihood of PCOS, multivariate logistic analysis was used. The strength of the association was tested further by receiver-operating characteristic (ROC) curve models, with or without the addition of HO-1.
   Compared with controls, women with PCOS were found to have significantly increased insulin resistance (IR), oxidative stress (OS) and inflammation levels, creating a vicious circle of effects in the pathophysiology of PCOS. However, serum HO-1 was negatively associated with this vicious circle. Women with the highest tertile of HO-1 (5.29 ng/ml) had an odds ratio (OR) of PCOS of 0.02 (95 CI 0.00340.07) compared with women with the lowest quartile (3.14 ng/ml) (P 0.01). This trend remained after adjustment for potential confounders in the multivariable model (all P 0.01). ROC analysis based on an existing prognostic model yielded significantly discriminative values for PCOS, with or without the addition of HO-1 (areas under the curves were 0.86 (95 CI 0.810.92) versus 0.95 (95 CI 0.920.98); P for difference 0.0005).
   It is difficult to establish a time-integrated measure of circulating HO-1 during the progression of PCOS and these findings should be confirmed in large-scale studies involving different ethnic groups. Moreover, the study lacks measurements of glycated hemoglobin (HbA(1c)) to provide an index of blood glucose concentrations over time.
   Circulating HO-1 that provides protection against IR, OS and chronic inflammation is markedly reduced in non-obese women with PCOS. Low serum HO-1 is suggested as an independent risk factor for PCOS; thus, circulating HO-1 levels may be a novel biomarker for PCOS in young, non-obese women.
   This work was supported by grants from the National Natural Science Foundation of China (81202210) and the National Science and Technology Support Program of China (2012BAI02B02). None of the authors has any conflict of interest to declare.
C1 [Gao, Hui; Xu, Mengjing; Jin, Yilin; Sun, Taoping; Huang, Hao; Wang, Di; Liu, Liegang] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Hubei Key Lab Food Nutr & Safety,Dept Nutr & Food, Wuhan 430030, Peoples R China.
   [Gao, Hui; Xu, Mengjing; Zhang, Shun; Jin, Yilin; Sun, Taoping; Huang, Hao; Wang, Di; Liu, Liegang] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, MOE Key Lab Environm & Hlth, Wuhan 430030, Peoples R China.
   [Meng, Jie; Zhang, Hanwang] Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Reprod Med Ctr, Wuhan 430030, Peoples R China.
   [Meng, Jie; Xing, Hui] Hubei Univ Arts & Sci, Dept Obstet & Gynecol, Xiangyang Centrol Hosp, Xiangyang 441021, Peoples R China.
   [Nie, Shuke] Huazhong Univ Sci & Technol, Union Hosp, Dept Neurol, Tongji Med Coll, Wuhan 430030, Peoples R China.
   [Wang, Di] Xiangyang Food & Drug Adm, Xiangyang 441021, Peoples R China.
C3 Huazhong University of Science & Technology; Huazhong University of
   Science & Technology; Huazhong University of Science & Technology; Hubei
   University of Arts & Science; Huazhong University of Science &
   Technology
RP Liu, LG (corresponding author), Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Hubei Key Lab Food Nutr & Safety,Dept Nutr & Food, Wuhan 430030, Peoples R China.
EM wad1983@126.com; lgliu@mails.tjmu.edu.cn
RI shuke, nie/S-9784-2019; Zhang, Shun/CAA-8456-2022
OI nie, shuke/0000-0003-3776-2749; Sun, Taoping/0000-0002-6412-5166
FU National Natural Science Foundation of China [81202210]; National
   Science and Technology Support Program of China [2012BAI02B02]
FX This work was supported by grants from the National Natural Science
   Foundation of China (81202210) and the National Science and Technology
   Support Program of China (2012BAI02B02).
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NR 40
TC 10
Z9 13
U1 0
U2 11
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0268-1161
EI 1460-2350
J9 HUM REPROD
JI Hum. Reprod.
PD MAY
PY 2014
VL 29
IS 5
BP 1058
EP 1066
DI 10.1093/humrep/deu029
PG 9
WC Obstetrics & Gynecology; Reproductive Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology; Reproductive Biology
GA AF7UX
UT WOS:000334921400017
PM 24585089
OA Bronze
DA 2025-06-11
ER

PT J
AU Maresch, CC
   Stute, DC
   Alves, MG
   Oliveira, PF
   de Kretser, DM
   Linn, T
AF Maresch, Constanze C.
   Stute, Dina C.
   Alves, Marco G.
   Oliveira, Pedro F.
   de Kretser, David M.
   Linn, Thomas
TI Diabetes-induced hyperglycemia impairs male reproductive function: a
   systematic review
SO HUMAN REPRODUCTION UPDATE
LA English
DT Review
DE hyperglycemia; diabetes mellitus type 1; blood glucose; insulin; male
   infertility; testis; prostate; epididymis; activins; poly(ADP-ribose)
   polymerases
ID POLY(ADP-RIBOSE) POLYMERASE ACTIVATION; PITUITARY-TESTICULAR AXIS;
   GLYCATION END-PRODUCTS; RAT SERTOLI CELLS; HIGH-ENERGY DIETS; OXIDATIVE
   STRESS; RETROGRADE EJACULATION; DNA-DAMAGE; GLUCOSE TRANSPORTERS;
   INSULIN REPLACEMENT
AB BACKGROUND: Hyperglycemia can result from a loss of pancreatic beta-cells or a decline in their function leading to decreased insulin secretion or may arise from insulin resistance and variable degrees of inadequate insulin secretion resulting in diabetes and related comorbidities. To date several reviews have addressed the issue of diabetes-related male infertility but most have focused on how metabolic syndrome causes the decline in male fertility. However, a comprehensive overview as to how diabetes-induced hyperglycemia impairs male fertility is missing. Impaired regulation of glucose and the resultant hyperglycemia are major threats to the health of individuals in modern societies especially given the rapidly rising prevalence affecting an increasing number of men in their reproductive years. Consequently, diabetes-induced hyperglycemia is likely to contribute to a decline in global birth rates especially in those societies with a high diabetic prevalence.
   OBJECTIVE AND RATIONALE: This systematic review addresses and summarizes the impact of hyperglycemia on male reproductive health with a particular emphasis on the molecular mechanisms that influence the testis and other parts of the male reproductive tract.
   SEARCH METHODS: A systematic search of the literature published in the MEDLINE-Pubmed database (http://www.ncbi.nlm.nih.gov/pubmed) and Cochrane Library (http://www.cochranelibrary.com) was performed, as well as hand searching reference lists, from the earliest available online indexing year until May 2017, using diabetes-and male fertility-related keywords in combination with other search phrases relevant to the topic of hyperglycemia. Inclusion criteria were: clinical studies on type 1 diabetic (T1D) men and studies on T1D animal models with a focus on reproductive parameters. Case reports/series, observational studies and clinical trials were included. Studies on patients with type 2 diabetes (T2D) or animal models of T2D were excluded to distinguish hyperglycemia from other metabolic effects.
   OUTCOMES: A total of 890 articles were identified of which 197 (32 clinical, 165 animal studies) were selected for qualitative analysis. While the clinical data from men with hyperglycemia-induced reproductive dysfunction were reported in most studies on T1D, the study designs were variable and lacked complete information on patients. Moreover, only a few studies (and mostly animal studies) addressed the underlying mechanisms of how hyperglycemia induces infertility. Potential causes included impaired function of the hypothalamic-pituitary-gonadal axis, increased DNA damage, perturbations in the system of advanced glycation endproducts and their receptor, oxidative stress, increased endoplasmatic reticulum stress, modulation of cellular pathways, impaired mitochondrial function and disrupted sympathetic innervation. However, intervention studies to identify and confirm the pathological mechanisms were missing: data that are essential in understanding these interactions.
   WIDER IMPLICATIONS: While the effects of regulating the hyperglycemia by the use of insulin and other modulators of glucose metabolism have been reported, more clinical trials providing high quality evidence and specifically addressing the beneficial effects on male reproduction are required. We conclude that interventions using insulin to restore normoglycemia should be a feasible approach to assess the proposed underlying mechanisms of infertility.
C1 [Maresch, Constanze C.; Stute, Dina C.; Linn, Thomas] Justus Liebig Univ, Ctr Internal Med, Clin Res Unit, Klin Str 33, Giessen, Germany.
   [Maresch, Constanze C.; de Kretser, David M.] Monash Univ, Hudson Inst Med Res, Melbourne, Australia.
   [Maresch, Constanze C.; de Kretser, David M.] Monash Univ, Dept Anat & Dev Biol, Melbourne, Australia.
   [Alves, Marco G.; Oliveira, Pedro F.] Univ Porto, Inst Biomed Sci Abel Salazar ICBAS, Dept Microscopy, Lab Cell Biol, Oporto, Portugal.
   [Alves, Marco G.; Oliveira, Pedro F.] Univ Porto, Inst Biomed Sci Abel Salazar ICBAS, Unit Multidisciplinary Res Biomed UMIB, Oporto, Portugal.
   [Oliveira, Pedro F.] Univ Porto, Fac Med, Dept Genet, Oporto, Portugal.
   [Oliveira, Pedro F.] Univ Porto, Inst Invest Inovacao Saude I3S, Oporto, Portugal.
C3 Justus Liebig University Giessen; Hudson Institute of Medical Research;
   Monash University; Monash University; Universidade do Porto;
   Universidade do Porto; Universidade do Porto; Universidade do Porto; i3S
   - Instituto de Investigacao e Inovacao em Saude, Universidade do Porto
RP Maresch, CC (corresponding author), Justus Liebig Univ, Ctr Internal Med, Clin Res Unit, Klin Str 33, Giessen, Germany.
EM Constanze.C.Maresch@chiru.med.uni-giessen.de
RI Alves, Marco/G-4821-2010; Oliveira, Pedro Fontes/G-4795-2010
OI Oliveira, Pedro Fontes/0000-0002-4989-5699; Maresch,
   Constanze/0000-0002-4685-535X; Alves, Marco G./0000-0001-7635-783X
FU State of Hessia (LOEWE-MIBI); Bundesministerium fur Bildung und
   Forschung [BMBF 01DL13015]; Deutsche Forschungsgemeinschaft (DFG)
   [353/17-1]; DFG as part of an International Research Training Group
   project [1871/8]; National Health and Medical Research Council of
   Australia (NHMRC) Project Grant [1063843]; Victorian Government's
   Operational Infrastructure Support Program; "Fundacao para a Ciencia e a
   Tecnologia"-FCT - Fundo Europeu de Desenvolvimento Regional-FEDER via
   Programa Operacional Factores de Competitividade-COMPETE/QREN
   [PEst-OE/SAU/UI0215/2014, SFRH/BPD/108837/2015, PTDC/BBB-BQB/1368/2014,
   SFRH/BPD/80451/2011, PTDC/BIMMET/4712/2014]; National Health and Medical
   Research Council of Australia [1063843] Funding Source: NHMRC
FX The State of Hessia (LOEWE-MIBI, T.L.), the Bundesministerium fur
   Bildung und Forschung (BMBF 01DL13015, T.L.), the Deutsche
   Forschungsgemeinschaft (DFG, 353/17-1, T.L.), the DFG as part of an
   International Research Training Group project (1871/8), by a National
   Health and Medical Research Council of Australia (NHMRC) Project Grant
   (1063843; to D.M.de.K.), by the Victorian Government's Operational
   Infrastructure Support Program, and by the "Fundacao para a Ciencia e a
   Tecnologia"-FCT co-funded by Fundo Europeu de Desenvolvimento
   Regional-FEDER via Programa Operacional Factores de
   Competitividade-COMPETE/QREN to Unit for Multidisciplinary Research in
   Biomedicine (UMIB), Projectos de IC&DT Estrategicos e de Interesse
   Publico (PEst-OE/SAU/UI0215/2014); P.F.O. (SFRH/BPD/108837/2015;
   PTDC/BBB-BQB/1368/2014) and M.G.A. (SFRH/BPD/80451/2011;
   PTDC/BIMMET/4712/2014). The funders had no role in study design, data
   collection and analysis, decision to publish, or preparation of the
   manuscript.
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NR 209
TC 216
Z9 224
U1 3
U2 51
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1355-4786
EI 1460-2369
J9 HUM REPROD UPDATE
JI Hum. Reprod. Update
PD JAN-FEB
PY 2018
VL 24
IS 1
BP 86
EP 105
DI 10.1093/humupd/dmx033
PG 20
WC Obstetrics & Gynecology; Reproductive Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology; Reproductive Biology
GA FU6SJ
UT WOS:000423982500005
PM 29136166
OA Bronze
DA 2025-06-11
ER

PT J
AU Cao, G
   González, J
   Fragola, JPO
   Muller, A
   Tumarkin, M
   Moriondo, M
   Azzato, F
   Blanco, MV
   Milei, J
AF Cao, Gabriel
   Gonzalez, Julian
   Ortiz Fragola, Juan P.
   Muller, Angelica
   Tumarkin, Mariano
   Moriondo, Marisa
   Azzato, Francisco
   Vazquez Blanco, Manuel
   Milei, Jose
TI Structural changes in endocrine pancreas of male Wistar rats due to
   chronic cola drink consumption. Role of PDX-1
SO PLOS ONE
LA English
DT Article
ID SUGAR-SWEETENED BEVERAGES; NUCLEUS-ACCUMBENS SHELL; INSULIN-RESISTANCE;
   GLUCAGON-SECRETION; OXIDATIVE STRESS; WEIGHT-GAIN; SOFT DRINK; GLUCOSE;
   FRUCTOSE; SUCROSE
AB Aim: The objective of this work was to analyze the structural changes of the pancreatic islets in rats, after 6 month consuming regular and light cola for 6 months. Also, we have analyzed the possible role of PDX-1 in that process. Finally, with the available knowledge, we propose a general working hypothesis that explains the succession of phenomena observed. Previously, we reported evidence showing that chronic cola consumption in rats impairs pancreatic metabolism of insulin and glucagon and produces some alterations typically observed in the metabolic syndrome, with an increase in oxidative stress. Of note It is worth mentioning that no apoptosis nor proliferation of islet cells could be demonstrated. In the present study, 36 male Wistar rats were divided into three groups to and given free access to freely drink regular cola (C), light cola (L), or water (W, control). We assessed the impact of the three different beverages in on glucose tolerance, lipid levels, creatinine levels and immunohistochemical changes addressed for the expression of insulin, glucagon, PDX-1 and NGN3 in islet cells, to evaluate the possible participation of PDX-1 in the changes observed in alpha and beta cells after 6 months of treatment. Moreover, we assessed by stereological methods, the mean volume of islets (Vi) and three important variables: the fractional beta -cell area, the cross-sectional area of alpha (A alpha-cell) and beta cells (A beta-cell), and the number of beta and alpha cell per body weight. Data were analyzed by two-way ANOVA followed by Bonferroni's multiple t-test or by Kruskal-Wallis test, then followed by Dunn's test (depending on distribution). Statistical significance was set at p<0.05. Cola drinking caused impaired glucose tolerance as well as fasting hyperglycemia (mean:148; CI:137-153; p<0.05 vs W) and an increase of in insulin immunolabeling (27.3 +/- 19.7; p<0.05 vs W and L). Immunohistochemical expression for PDX-1 was significantly high in C group compared to W (0.79 +/- 0.71; p<0.05). In this case, we observed cytoplasmatic and nuclear localization. Likewise, a mild but significant decrease of in Vi was detected after 6 months in C compared to W group (8.2 +/- 2.5; p<0.05). Also, we observed a significant decrease of in the fractional beta cell area (78.2 +/- 30.9; p<0.05) compared to W. Accordingly, a reduced mean value of islet alpha and beta cell number per body weight (0.05 +/- 0.02 and 0.08 +/- 0.04 respectively; both p<0.05) compared to W was detected. Interestingly, consumption of light cola increased the Vi (10.7 +/- 3.6; p<0.05) compared to W. In line with this, a decreased cross-sectional area of beta-cells was observed after chronic consumption of both, regular (78.2 +/- 30.9; p<0.05) and light cola (110.5 +/- 24.3; p<0.05), compared to W. As for, NGN3, it was negative in all three groups. Our results support the idea that PDX-1 plays a key role in the dynamics of the pancreatic islets after chronic consumption of sweetened beverages. In this experimental model, the loss of islets cells might be attributed to autophagy, favored by the local metabolic conditions and oxidative stress.
C1 [Cao, Gabriel] Univ Abierta Interamer, Ctr Altos Estudios Ciencias Humanas & Salud CAECI, Buenos Aires, DF, Argentina.
   [Gonzalez, Julian; Ortiz Fragola, Juan P.; Muller, Angelica; Tumarkin, Mariano; Moriondo, Marisa; Milei, Jose] Consejo Nacl Invest Cient & Tecn, Consejo Nacl Invest Cient & Tecn, Buenos Aires, DF, Argentina.
   [Azzato, Francisco; Vazquez Blanco, Manuel; Milei, Jose] Univ Buenos Aires, CONICET, Fac Med, Inst Alberto C Taquini Invest Med Traslac IATIMET, Buenos Aires, DF, Argentina.
   Hosp Clin Buenos Aires, Fac Med, Sexta Catedra Med, Buenos Aires, DF, Argentina.
C3 Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET);
   University of Buenos Aires; Consejo Nacional de Investigaciones
   Cientificas y Tecnicas (CONICET); University of Buenos Aires; University
   of Buenos Aires Hospital
RP Cao, G (corresponding author), Univ Abierta Interamer, Ctr Altos Estudios Ciencias Humanas & Salud CAECI, Buenos Aires, DF, Argentina.
EM gabrielcao@fibertel.com.ar
RI Cao, Gabriel/LJL-8755-2024
FU University of Buenos Aires, Argentina [UBACYT 20020150100027BA]
FX The author JM, received specific funding for this work from University
   of Buenos Aires, Argentina, UBACYT 20020150100027BA.
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NR 60
TC 3
Z9 3
U1 1
U2 3
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JUN 11
PY 2021
VL 16
IS 6
AR e0243340
DI 10.1371/journal.pone.0243340
PG 17
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA SW6SD
UT WOS:000664643000002
PM 34115756
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Kemp, DE
   Gao, KM
   Ganocy, SJ
   Caldes, E
   Feldman, K
   Chan, PK
   Conroy, C
   Bilali, S
   Findling, RL
   Calabrese, JR
AF Kemp, David E.
   Gao, Keming
   Ganocy, Stephen J.
   Caldes, Emily
   Feldman, Kathryn
   Chan, Philip K.
   Conroy, Carla
   Bilali, Sarah
   Findling, Robert L.
   Calabrese, Joseph R.
TI Medical and substance use comorbidity in bipolar disorder
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Bipolar disorder; Medical comorbidity; Cumulative Illness Rating Scale;
   Substance use disorders; Rapid cycling; Lithium; Valproate
ID MAJOR DEPRESSIVE DISORDER; ILLNESS RATING-SCALE; PITUITARY-ADRENAL AXIS;
   I-DISORDER; METABOLIC SYNDROME; PHYSICAL ILLNESS; ALCOHOL; BURDEN;
   HEALTH; PREVALENCE
AB Objective: National Comorbidity Survey data indicate that bipolar disorder is characterized by high lifetime rates of co-occurring anxiety and substance use disorders (SUDs). Although compelling evidence suggests SLID comorbidity predicts non-response to treatment, the relationship between medical comorbidity and treatment response has not been studied adequately. In an attempt to understand the impact of medical comorbidity on treatment outcome, an analysis was conducted to inform the relationship between co-occurring medical illness, the phenomenology of bipolar disorder, and response to treatment with mood stabilizers.
   Method: A total of 98 adult outpatients with rapid-cycling bipolar I or II disorder and co-occurring SUDs were prospectively treated with the combination of lithium and valproate for up to 24 weeks. A logistic regression analysis was conducted to explore the relationship between phenomenology, response to mood stabilizers, and medical comorbidity as assessed by the Cumulative Illness Rating Scale (CIRS). High and low medical comorbidity burden were defined as a CIRS total score 4 and 3, respectively.
   Results: Every patient enrolled into this study had at least 1 medical illness (most commonly respiratory, 72%) and on average had 4.9 different medical conditions. Over half of patients (52%) exhibited illnesses across four or more different organ systems, 24% had uncontrollable medical illnesses, and the mean overall total CIRS score was 5.56. The average body mass index (BMI) was 28.1 with 38% being overweight and 29% being obese. High medical burden was observed in 64% and was most strongly predicted by a diagnosis of bipolar I disorder (OR = 34.9, p = 0.002, 95%CI = 3.9-316.1). A history of attempted suicide (OR = 10.3, p = 0.01, 95%CI = 1.7-62.0), a history of physical abuse (OR = 7.6, p = 0.03, 95%CI = 1.3-45.7) and advancing age (OR = 1.2, p<0.001, 95%CI = 1.1-1.3) also independently predicted a high burden of general medical problems. Only 21% (N = 21) of subjects enrolled into this study showed a bimodal response to treatment with lithium plus valproate, and neither BMI nor any summary CIRS measure predicted response.
   Conclusion: Rapid cycling with co-occurring substance use is not only associated with poor response to mood stabilizers, but is also a harbinger of serious medical problems. A high burden of medical comorbidity was associated with the bipolar I subtype, a history of attempted suicide, a history of physical abuse, and advancing age. (C) 2008 Elsevier B.V. All rights reserved.
C1 [Kemp, David E.; Gao, Keming; Ganocy, Stephen J.; Caldes, Emily; Feldman, Kathryn; Chan, Philip K.; Conroy, Carla; Bilali, Sarah; Findling, Robert L.; Calabrese, Joseph R.] Case Western Reserve Univ, Univ Hosp, Case Med Ctr, Cleveland, OH 44106 USA.
C3 University System of Ohio; Case Western Reserve University; University
   Hospitals of Cleveland
RP Kemp, DE (corresponding author), 10524 Euclid Ave,12th Floor, Cleveland, OH 44106 USA.
EM kemp.david@gmail.com
RI Gao, Keming/W-6017-2019
FU NIH [R01 MH-50165, P20 MH-66054, 1KL2RR024990]
FX Funding for this study was provided by NIH grants R01 MH-50165 to Dr.
   Calabrese, P20 MH-66054 to Drs. Calabrese and Findling, and in part by
   1KL2RR024990 to Dr. Kemp. The NIH had no further role in the study
   design; in the collection, analysis and interpretation of data; in the
   writing of the report; and in the decision to submit the paper for
   publication.
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NR 39
TC 30
Z9 33
U1 0
U2 9
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0165-0327
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD JUL
PY 2009
VL 116
IS 1-2
BP 64
EP 69
DI 10.1016/j.jad.2008.11.011
PG 6
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA 461EI
UT WOS:000267247000011
PM 19100627
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Cadney, MD
   Hiramatsu, L
   Thompson, Z
   Zhao, M
   Kay, JC
   Singleton, JM
   de Albuquerque, RL
   Schmill, MP
   Saltzman, W
   Garland, T
AF Cadney, Marcell D.
   Hiramatsu, Layla
   Thompson, Zoe
   Zhao, Meng
   Kay, Jarren C.
   Singleton, Jennifer M.
   de Albuquerque, Ralph Lacerda
   Schmill, Margaret P.
   Saltzman, Wendy
   Garland, Theodore, Jr.
TI Effects of early-life exposure to Western diet and voluntary exercise on
   adult activity levels, exercise physiology, and associated traits in
   selectively bred High Runner mice
SO PHYSIOLOGY & BEHAVIOR
LA English
DT Article
DE Developmental programming; Early-life effects; Exercise; Reward; Western
   diet; Wheel running
ID HIGH-FAT DIET; SPONTANEOUS PHYSICAL-ACTIVITY; WHEEL-RUNNING BEHAVIOR;
   DEVELOPMENTAL ORIGINS; SEXUAL-DIMORPHISM; ARTIFICIAL SELECTION; HOUSE
   MICE; CARDIOVASCULAR-DISEASE; ENERGY-EXPENDITURE; METABOLIC SYNDROME
AB Exercise behavior is under partial genetic control, but it is also affected by numerous environmental factors, potentially including early-life experiences whose effects persist into adulthood. We studied genetic and early-life environmental effects on wheel-running behavior in a mouse model that includes four replicate high runner (HR) lines selectively bred for increased voluntary wheel running as young adults and four non-selected control (C) lines. In a full factorial design, mice from each line were granted wheel access or not and administered either standard or Western diet (WD) from weaning (3 weeks old) to 6 weeks of age (sexual maturity). In addition to acute effects, after a washout period of 8 weeks (similar to 6 human years) in which all mice had standard diet and no wheel access, we found both beneficial and detrimental effects of these early-life exposures. During the first week of treatments, WD increased distance run by 29% in C mice and 48% in HR mice (significant Diet x Linetype interaction), but diet effects disappeared by the third week. Across the three weeks of juvenile treatment, WD significantly increased fat mass (with lean mass as a covariate). Tested as adults, early-life exercise increased wheel running of C mice but not HR mice in the first week. Early-life exercise also reduced adult anxiety-like behavior and increased adult fasted blood glucose levels, triceps surae mass, subdermal fat pad mass, and brain mass, but decreased heart ventricle mass. Using fat mass as a covariate, early-life exercise treatment increased adult leptin concentration. In contrast, early-life WD increased adult wheel running of HR mice but not C mice. Early-life WD also increased adult lean mass and adult preference for Western diet in all groups. Surprisingly, early-life treatment had no significant effect on adult body fat or maximal aerobic capacity (VO(2)max). No previous study has tested for combined or interactive effects of early-life WD and exercise. Our results demonstrate that both factors can have long-lasting effects on adult voluntary exercise and related phenotypes, and that these effects are modulated by genetic background. Overall, the long-lasting effects of early-life exercise were more pervasive than those of WD, suggesting critical opportunities for health intervention in childhood habits, as well as possible threats from modern challenges. These results may be relevant for understanding potential effects of activity reductions and dietary changes associated with the obesity epidemic and COVID-19 pandemic.
C1 [Cadney, Marcell D.; Hiramatsu, Layla; Zhao, Meng; Kay, Jarren C.; Singleton, Jennifer M.; de Albuquerque, Ralph Lacerda; Saltzman, Wendy; Garland, Theodore, Jr.] Univ Calif Riverside, Dept Evolut Ecol & Organismal Biol, Riverside, CA 92521 USA.
   [Thompson, Zoe; Schmill, Margaret P.] Univ Calif Riverside, Neurosci Grad Program, Riverside, CA 92521 USA.
C3 University of California System; University of California Riverside;
   University of California System; University of California Riverside
RP Garland, T (corresponding author), Univ Calif Riverside, Dept Evolut Ecol & Organismal Biol, Riverside, CA 92521 USA.
EM tgarland@ucr.edu
OI Zhao, Meng/0000-0002-5415-8335
FU US NIH [R21HD084856]; US NSF [DEB-1655362]; US USDA project
   [CA-R-EEOB-5205-H]
FX This work was supported US NIH grant R21HD084856 to T.G. and Wendy
   Saltzman, in part by US NSF grant DEB-1655362 to T.G., and in part by US
   USDA project CA-R-EEOB-5205-H to T.G. We thank M. A. Chappell for
   technical and methodological assistance, and T. H. Meek helpful
   discussions.
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NR 182
TC 20
Z9 27
U1 2
U2 12
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0031-9384
EI 1873-507X
J9 PHYSIOL BEHAV
JI Physiol. Behav.
PD MAY 15
PY 2021
VL 234
AR 113389
DI 10.1016/j.physbeh.2021.113389
EA MAR 2021
PG 15
WC Psychology, Biological; Behavioral Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Behavioral Sciences
GA RN2MU
UT WOS:000640186900015
PM 33741375
OA Green Accepted, Green Submitted
DA 2025-06-11
ER

PT J
AU Gannamani, R
   Forte, JC
   Folkertsma, P
   Hermans, S
   Kumaraswamy, S
   van Dam, S
   Chavannes, N
   van Os, H
   Pijl, H
   Wolffenbuttel, BHR
AF Gannamani, Rahul
   Forte, Jose Castela
   Folkertsma, Pytrik
   Hermans, Sven
   Kumaraswamy, Sridhar
   van Dam, Sipko
   Chavannes, Niels
   van Os, Hendrikus
   Pijl, Hanno
   Wolffenbuttel, Bruce H. R.
TI A Digitally Enabled Combined Lifestyle Intervention for Weight Loss:
   Pilot Study in a Dutch General Population Cohort
SO JMIR FORMATIVE RESEARCH
LA English
DT Article
DE lifestyle intervention; prevention; obesity; overweight; weight loss;
   digital health; intervention; weight; pilot; digital; data; Fogg
   Behavior Model
ID BEHAVIORAL DETERMINANTS; HEALTH INTERVENTIONS; MOBILE APPLICATIONS;
   PHYSICAL-ACTIVITY; PREVENTION; MANAGEMENT; EFFICACY; OBESITY; ADULTS
AB Background: Overweight and obesity rates among the general population of the Netherlands keep increasing. Combined lifestyle interventions (CLIs) focused on physical activity, nutrition, sleep, and stress management can be effective in reducing weight and improving health behaviors. Currently available CLIs for weight loss (CLI-WLs) in the Netherlands consist of face-to-face and community -based sessions, which face scalability challenges. A digitally enabled CLI-WL with digital and human components may provide a solution for this challenge; however, the feasibility of such an intervention has not yet been assessed in the Netherlands. Objective: The aim of this study was two -fold: (1) to determine how weight and other secondary cardiometabolic outcomes (lipids and blood pressure) change over time in a Dutch population with overweight or obesity and cardiometabolic risk participating in a pilot digitally enabled CLI-WL and (2) to collect feedback from participants to guide the further development of future iterations of the intervention. Methods: Participants followed a 16 -week digitally enabled lifestyle coaching program rooted in the Fogg Behavior Model, focused on nutrition, physical activity, and other health behaviors, from January 2020 to December 2021. Participants could access the digital app to register and track health behaviors, weight, and anthropometrics data at any time. We retrospectively analyzed changes in weight, blood pressure, and lipids for remeasured users. Surveys and semistructured interviews were conducted to assess critical positive and improvement points reported by participants and health care professionals. Results: Of the 420 participants evaluated at baseline, 53 participated in the pilot. Of these, 37 (70%) were classified as overweight and 16 (30%) had obesity. Mean weight loss of 4.2% occurred at a median of 10 months postintervention. The subpopulation with obesity (n=16) showed a 5.6% weight loss on average. Total cholesterol decreased by 10.2% and low -density lipoprotein cholesterol decreased by 12.9% on average. Systolic and diastolic blood pressure decreased by 3.5% and 7.5%, respectively. Participants identified the possibility of setting clear action plans to work toward and the multiple weekly touch points with coaches as two of the most positive and distinctive components of the digitally enabled intervention. Surveys and interviews demonstrated that the digital implementation of a CLI-WL is feasible and well -received by both participants and health care professionals. Conclusions: Albeit preliminary, these findings suggest that a behavioral lifestyle program with a digital component can achieve greater weight loss than reported for currently available offline CLI-WLs. Thus, a digitally enabled CLI-WL is feasible and may be a scalable alternative to offline CLI-WL programs. Evidence from future studies in a Dutch population may help elucidate the mechanisms behind the effectiveness of a digitally enabled CLI-WL.
C1 [Gannamani, Rahul; Forte, Jose Castela; Folkertsma, Pytrik; Hermans, Sven; Kumaraswamy, Sridhar; van Dam, Sipko] Ancora Hlth BV, Herepl 34, NL-9711 LM Groningen, Netherlands.
   [Gannamani, Rahul] Univ Groningen, Univ Med Ctr Groningen, Dept Neurol, Groningen, Netherlands.
   [Forte, Jose Castela] Univ Groningen, Univ Med Ctr Groningen, Dept Clin Pharm & Pharmacol, Groningen, Netherlands.
   [Folkertsma, Pytrik; van Dam, Sipko; Wolffenbuttel, Bruce H. R.] Univ Groningen, Univ Med Ctr Groningen, Dept Endocrinol, Groningen, Netherlands.
   [Chavannes, Niels; van Os, Hendrikus] Leiden Univ, Dept Publ Hlth & Primary Care, Med Ctr, Leiden, Netherlands.
   [Chavannes, Niels; van Os, Hendrikus] Natl EHlth Living Lab, Leiden, Netherlands.
   [Pijl, Hanno] Leiden Univ, Dept Endocrinol, Med Ctr, Leiden, Netherlands.
C3 University of Groningen; University of Groningen; University of
   Groningen; Leiden University; Leiden University Medical Center (LUMC);
   Leiden University - Excl LUMC; Leiden University - Excl LUMC; Leiden
   University; Leiden University Medical Center (LUMC)
RP Forte, JC (corresponding author), Ancora Hlth BV, Herepl 34, NL-9711 LM Groningen, Netherlands.
EM jose@ancora.health
RI ; Chavannes, Niels Henrik/F-1148-2011; Pijl, Hanno/W-8719-2018
OI Folkertsma, Pytrik/0000-0003-1823-8706; Castela Forte,
   Jose/0000-0001-9273-0702; Chavannes, Niels Henrik/0000-0002-8607-9199;
   Pijl, Hanno/0000-0002-3076-1551; van Os, Hendrikus/0000-0002-8911-8608;
   Gannamani, Rahul/0000-0003-4576-2271; Wolffenbuttel, Bruce
   H.R./0000-0001-9262-6921
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NR 62
TC 1
Z9 1
U1 1
U2 2
PU JMIR PUBLICATIONS, INC
PI TORONTO
PA 130 QUEENS QUAY East, Unit 1100, TORONTO, ON M5A 0P6, CANADA
EI 2561-326X
J9 JMIR FORM RES
JI JMIR Form. Res.
PY 2024
VL 8
AR e38891
DI 10.2196/38891
PG 13
WC Health Care Sciences & Services; Medical Informatics
WE Emerging Sources Citation Index (ESCI)
SC Health Care Sciences & Services; Medical Informatics
GA IG3X9
UT WOS:001165148700005
PM 38329792
OA gold, Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Gandolfi, MG
   Zamparini, F
   Spinelli, A
   Prati, C
AF Gandolfi, Maria Giovanna
   Zamparini, Fausto
   Spinelli, Andrea
   Prati, Carlo
TI Āsana for Back, Hips and Legs to Prevent Musculoskeletal Disorders among
   Dental Professionals: In-Office Yóga Protocol
SO JOURNAL OF FUNCTIONAL MORPHOLOGY AND KINESIOLOGY
LA English
DT Article
DE Yoga; Yoga Therapy; asana; musculoskeletal disorders; dental
   professionals; dental ergonomics; posture; low-back pain; spinopelvic
   mobility; iliopsoas syndrome; ischiofemoral impingement; piriformis
   syndrome; quadratus femoris dysfunction
ID PATELLOFEMORAL PAIN SYNDROME; RANDOMIZED CONTROLLED-TRIAL; CHRONIC NECK
   PAIN; YOGA THERAPY; METABOLIC SYNDROME; LUMBAR MULTIFIDUS; COMPARING
   YOGA; MUSCLE; METAANALYSIS; QUADRICEPS
AB Dental professionals are exposed to significant unavoidable physical stress, and theoretical ergonomic recommendations for a sitting workplace are inapplicable in many dental activities. Work-related musculoskeletal disorders (WMSDs) represent a serious health problem among dental professionals (prevalence: 64-93%), showing involvement of 34-60% for the low back and 15-25% for the hips. Muscle stress; prolonged sitting; forward bending and twisting of the torso and head; unbalanced working postures with asymmetrical weight on the hips and uneven shoulders; and others are inevitable for dental professionals. Therefore, the approach for the prevention and treatment of WMSDs must be therapeutic and compensatory. This project was conceived to provide a Yoga protocol for dental professionals to prevent or treat WMSDs from a preventive medicine perspective, and it would represent a Yoga-based guideline for the self-cure and prevention of musculoskeletal problems. Methods: Specific Yoga positions (asana, such as Virasana, Virabhadrasana, Garudasana, Utkatasana, Trikonasana, Anuvittasana, Chakrasana, Uttanasana, Pashimottanasana) have been selected, elaborated on and adapted to be practiced in a dental office using a dental stool or the dental office walls or a dental unit chair. The protocol is specifically devised for dental professionals (dentists, dental hygienists and dental assistants) and targeted for the low back, hips and legs (including knees and ankles). The protocol includes Visranta Karaka Sthiti (supported positions) in sitting (Upavistha Sthiti) and standing (Utthistha Sthiti) positions, twisting/torsions (Parivrtta), flexions/forward bend positions (Pashima) and extensions/arching (Purva) for musculo-articular system decompression and mobilization. Results: Over 60 Yogasana-specifically ideated for back detensioning and mobilization, lumbar lordosis restoration, trunk side elongation, hip release and leg stretches and decontraction-are shown and described. The paper provides a meticulous description for each position, including the detailed movement, recommendations and mistakes to avoid, and the breathing pattern (breath control) in all the breath-driven movements (asana in vinyasa). An exhaustive analysis of posture-related disorders affecting the lower body among dental professionals is reported, including low-back pain, hip pain and disorders, piriformis syndrome and quadratus femoris dysfunction (gluteal pain), iliopsoas syndrome, multifidus disorders, femoroacetabular and ischiofemoral impingement, spinopelvic mobility, lumbopelvic rhythm, impairment syndromes, lower crossed syndrome, leg pain, knee pain and ankle disorders. Conclusions: A detailed guideline of asana for low-back decompression, hip joint destress, piriformis and gluteal muscle release, lumbar lordosis recovery and a spinopelvic mobility increase has been elaborated on. The designed Yogasana protocol represents a powerful tool for dental professionals to provide relief to retracted stiff muscles and unbalanced musculoskeletal structures in the lower body.
C1 [Gandolfi, Maria Giovanna] Univ Bologna, Sch Med, Program Ergon Posturol & Yoga Therapy Degree Dent, I-40125 Bologna, Italy.
   [Gandolfi, Maria Giovanna] Univ Bologna, Sch Med, Program Yoga Therapy Specializat Course Sports Med, I-40125 Bologna, Italy.
   [Gandolfi, Maria Giovanna; Zamparini, Fausto; Spinelli, Andrea; Prati, Carlo] Univ Bologna, Dent Sch, Dept Biomed & Neuromotor Sci, I-40125 Bologna, Italy.
C3 University of Bologna; University of Bologna; University of Bologna
RP Gandolfi, MG (corresponding author), Univ Bologna, Sch Med, Program Ergon Posturol & Yoga Therapy Degree Dent, I-40125 Bologna, Italy.; Gandolfi, MG (corresponding author), Univ Bologna, Sch Med, Program Yoga Therapy Specializat Course Sports Med, I-40125 Bologna, Italy.; Gandolfi, MG (corresponding author), Univ Bologna, Dent Sch, Dept Biomed & Neuromotor Sci, I-40125 Bologna, Italy.
EM mgiovanna.gandolfi@unibo.it; andrea.spinelli4@unibo.it;
   carlo.prati@unibo.it
RI ; Zamparini, Fausto/N-9625-2019
OI Spinelli, Andrea/0000-0002-4674-1766; Gandolfi, Maria
   Giovanna/0000-0001-7793-6227; Zamparini, Fausto/0000-0002-0071-4463
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NR 97
TC 3
Z9 3
U1 7
U2 15
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2411-5142
J9 J FUNCT MORPHOL KIN
JI J Funct. Morphol. Kinesiol.
PD MAR
PY 2024
VL 9
IS 1
AR 6
DI 10.3390/jfmk9010006
PG 32
WC Sport Sciences
WE Emerging Sources Citation Index (ESCI)
SC Sport Sciences
GA MI1L8
UT WOS:001192901900001
PM 38249083
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Fekedulegn, D
   Burchfiel, CM
   Hartley, TA
   Andrew, ME
   Charles, LE
   Tinney-Zara, CA
   Violanti, JM
AF Fekedulegn, Desta
   Burchfiel, Cecil M.
   Hartley, Tara A.
   Andrew, Michael E.
   Charles, Luenda E.
   Tinney-Zara, Cathy A.
   Violanti, John M.
TI Shiftwork and Sickness Absence Among Police Officers: The BCOPS Study
SO CHRONOBIOLOGY INTERNATIONAL
LA English
DT Article
DE BMI; police officers; shiftwork; sick leave; ungrouped poisson
   regression
ID RISK-FACTORS; METABOLIC SYNDROME; WORK FACTORS; LEAVE; SLEEP;
   ASSOCIATION; PREDICTORS; REFERENT; OBESITY; COHORT
AB Shiftwork, regarded as a significant occupational stressor, has become increasingly prevalent across a wide range of occupations. The adverse health outcomes associated with shiftwork are well documented. Shiftwork is an integral part of law enforcement, a high-stress occupation with elevated risks of chronic disease and mortality. Sickness absence is an important source of productivity loss and may also serve as an indirect measure of workers' morbidity. Prior studies of shiftwork and sickness absenteeism have yielded varying results and the association has not been examined specifically among police officers. The objective of this study was to compare the incidence rate of sick leave (any, >= 3 consecutive days) among day-, afternoon-, and night-shift workers in a cohort of police officers and also examine the role of lifestyle factors as potential moderators of the association. Participants (N = 464) from the Buffalo Cardio-Metabolic Occupational Police Stress (BCOPS) study examined between 2004 and 2009 were used. Daily work history records that included the shift schedule, number of hours worked, and occurrence of sick leave were available for up to 15 yrs starting in 1994 to the date of the BCOPS study examination for each officer. Poisson regression analysis for ungrouped data was used to estimate incidence rates (IRs) of sick leave by shift, and comparison of IRs across shifts were made by computing incidence rate ratios (IRRs) and their 95% confidence intervals (CIs). Sick leave occurred at a higher rate on the night shift (4.37 per 10 000 person-hours) compared with either day (1.55 per 10 000 person-hours) or afternoon (1.96 per 10 000 person-hours) shifts. The association between shiftwork and sickness absence depended on body mass index (BMI). For overweight individuals (BMI >= 25 kg/m(2)), the covariate-adjusted incidence rate of sick leave (>= 1 day) was twice as large for night-shift officers compared with those working on the day (IRR = 2.29, 95% CI: 1.69-3.10) or afternoon (IRR = 1.74, 95% CI: 1.29-2.34) shift. The IR of three or more consecutive days of sick leave was 1.7 times larger for those working on night shift (IRR = 1.65, 95% CI: 1.17-2.31) and 1.5 times larger for those working on afternoon shift (IRR = 1.50, 95% CI: 1.08-2.08) compared with day shiftworkers. For subjects with normal BMI (<25 kg/m(2)), the incidence rates of sick leave did not differ significantly across shifts. In conclusion, shiftwork is independently associated with sickness absence, with officers who work the night shift having elevated incidence of sick leave. In addition, overweight officers who work the night shift may be at additional risk for sickness absence.
C1 [Fekedulegn, Desta; Burchfiel, Cecil M.; Hartley, Tara A.; Andrew, Michael E.; Charles, Luenda E.; Tinney-Zara, Cathy A.] NIOSH, Biostat & Epidemiol Branch, Hlth Effects Lab Div, Ctr Dis Control & Prevent, Morgantown, WV 26505 USA.
   [Violanti, John M.] SUNY Buffalo, Sch Publ Hlth & Hlth Profess, Dept Social & Prevent Med, Buffalo, NY 14260 USA.
C3 Centers for Disease Control & Prevention - USA; National Institute for
   Occupational Safety & Health (NIOSH); State University of New York
   (SUNY) System; University at Buffalo, SUNY
RP Fekedulegn, D (corresponding author), NIOSH, HELD BEB, MS L-4050,1095 Willowdale Rd, Morgantown, WV 26505 USA.
EM djf7@cdc.gov
RI Charles, Luenda/H-6008-2011
OI Tinney-Zara, Cathy/0000-0002-6529-9619
FU National Institute for Occupational Safety and Health (NIOSH)
   [200-2003-01580]
FX This work was supported by the National Institute for Occupational
   Safety and Health (NIOSH), contract no. 200-2003-01580. The findings and
   conclusions in this article are those of the authors and do not
   necessarily represent the views of the National Institute for
   Occupational Safety and Health.
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NR 48
TC 46
Z9 70
U1 0
U2 33
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 0742-0528
EI 1525-6073
J9 CHRONOBIOL INT
JI Chronobiol. Int.
PY 2013
VL 30
IS 7
BP 930
EP 941
DI 10.3109/07420528.2013.790043
PG 12
WC Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Life Sciences & Biomedicine - Other Topics; Physiology
GA 176CL
UT WOS:000321280700008
PM 23808812
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Kopytek, M
   Mazur, P
   Zabczyk, M
   Undas, A
   Natorska, J
AF Kopytek, Magdalena
   Mazur, Piotr
   Zabczyk, Michal
   Undas, Anetta
   Natorska, Joanna
TI Diabetes concomitant to aortic stenosis is associated with increased
   expression of NF-κB and more pronounced valve calcification
SO DIABETOLOGIA
LA English
DT Article
DE Aortic stenosis; Bone morphogenetic protein 2; Coagulation factors;
   Diabetes mellitus; Inflammation; NF-kappa B; Oxidative stress
ID GLYCATION END-PRODUCTS; METABOLIC SYNDROME; PROGRESSION; RECEPTOR;
   INFLAMMATION; COAGULATION; PREVALENCE; ACCELERATE; DISEASE
AB Aims/hypothesis Type 2 diabetes has been demonstrated to predispose to aortic valve calcification. We investigated whether type 2 diabetes concomitant to aortic stenosis (AS) enhances valvular inflammation and coagulation activation via upregulated expression of NF-kappa B, with subsequent increased expression of bone morphogenetic protein 2 (BMP-2).
   Methods In this case-control study, 50 individuals with severe isolated AS and concomitant type 2 diabetes were compared with a control group of 100 individuals without diabetes. The median (IQR) duration of diabetes since diagnosis was 11 (7-18) years, and 36 (72%) individuals had HbA(1c) >= 48 mmol/mol (>= 6.5%). Stenotic aortic valves obtained during valve replacement surgery served for in loco NF-kappa B, BMP-2, prothrombin (FII) and active factor X (FXa) immunostaining. In vitro cultures of valve interstitial cells (VICs), isolated from obtained valves were used for mechanistic experiments and PCR investigations.
   Results Diabetic compared with non-diabetic individuals displayed enhanced valvular expression of NF-kappa B, BMP-2, FII and FXa (all p <= 0.001). Moreover, the expression of NF-kappa B and BMP-2 positively correlated with amounts of valvular FII and FXa. Only in diabetic participants, valvular NF-kappa B expression was strongly associated with serum levels of HbA(1c), and moderately with fructosamine. Of importance, in diabetic participants, valvular expression of NF-kappa B correlated with aortic valve area (AVA) and maximal transvalvular pressure gradient. In vitro experiments conducted using VIC cultures revealed that glucose (11 mmol/l) upregulated expression of both NF-kappa B and BMP-2 (p < 0.001). In VIC cultures treated with glucose in combination with reactive oxygen species (ROS) inhibitor (N-acetyl-l-cysteine), the expression of NF-kappa B and BMP-2 was significantly suppressed. A comparable effect was observed for VICs cultured with glucose in combination with NF-kappa B inhibitor (BAY 11-7082), suggesting that high doses of glucose activate oxidative stress leading to proinflammatory actions in VICs. Analysis of mRNA expression in VICs confirmed these findings; glucose caused a 6.9-fold increase in expression of RELA (NF-kappa B p65 subunit), with the ROS and NF-kappa B inhibitor reducing the raised expression of RELA by 1.8- and 3.2-fold, respectively.
   Conclusions/interpretation Type 2 diabetes enhances in loco inflammation and coagulation activation within stenotic valve leaflets. Increased valvular expression of NF-kappa B in diabetic individuals is associated not only with serum HbA(1c) and fructosamine levels but also with AVA and transvalvular gradient, indicating that strict long-term glycaemic control is needed in AS patients with concomitant type 2 diabetes. This study suggests that maintaining these variables within the normal range may slow the rate of AS progression.
C1 [Kopytek, Magdalena; Zabczyk, Michal; Undas, Anetta; Natorska, Joanna] John Paul 2 Hosp, Krakow, Poland.
   [Kopytek, Magdalena; Mazur, Piotr; Zabczyk, Michal; Undas, Anetta; Natorska, Joanna] Jagiellonian Univ Med Coll, Krakow, Poland.
C3 Jagiellonian University; Collegium Medicum Jagiellonian University
RP Natorska, J (corresponding author), John Paul 2 Hosp, Krakow, Poland.; Natorska, J (corresponding author), Jagiellonian Univ Med Coll, Krakow, Poland.
EM j.natorska@szpitaljp2.krakow.pl
RI Kopytek, Magdalena/KHE-3603-2024; Ząbczyk, Michał/AHA-6044-2022;
   Natorska, Joanna/AHA-6096-2022
OI Natorska, Joanna/0000-0003-3176-8007; Mazur, Piotr/0000-0003-4077-1232;
   Kopytek, Magdalena/0000-0002-4026-8971; Zabczyk,
   Michal/0000-0003-1762-308X
FU Polish National Science Centre [UMO-2015/19/B/NZ5/00647]
FX This work was supported by the grant from the Polish National Science
   Centre (UMO-2015/19/B/NZ5/00647 to JN).
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NR 39
TC 29
Z9 30
U1 0
U2 3
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0012-186X
EI 1432-0428
J9 DIABETOLOGIA
JI Diabetologia
PD NOV
PY 2021
VL 64
IS 11
BP 2562
EP 2574
DI 10.1007/s00125-021-05545-w
EA SEP 2021
PG 13
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA WE8JT
UT WOS:000693503300001
PM 34494136
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Kopytek, M
   Zabczyk, M
   Mazur, P
   Undas, A
   Natorska, J
AF Kopytek, Magdalena
   Zabczyk, Michal
   Mazur, Piotr
   Undas, Anetta
   Natorska, Joanna
TI Accumulation of advanced glycation end products (AGEs) is associated
   with the severity of aortic stenosis in patients with concomitant type 2
   diabetes
SO CARDIOVASCULAR DIABETOLOGY
LA English
DT Article
DE Aortic stenosis (AS); Diabetes mellitus (DM); Advanced glycation end
   products (AGEs); Inflammation; Oxidative stress
ID VALVE CALCIFICATION; SOLUBLE RAGE; METABOLIC SYNDROME; PROGRESSION;
   RECEPTOR; DISEASE; SERUM; ACCELERATE; STRESS; MICE
AB Background Accumulation of advanced glycation end products (AGEs) leads to chronic glycation of proteins and tissue damage, particularly in patients with diabetes mellitus (DM). We aimed to evaluate whether increased accumulation of AGEs in patients with aortic stenosis (AS) and concomitant type 2 diabetes (DM) is associated with AS severity. Methods We prospectively enrolled 76 patients with severe AS (47.1% males; nonDM), aged 68 [66-72] years, and 50 age-matched DM patients with a median blood glucose level of 7.5 [5.9-9.1] mM and glycated hemoglobin (HbA1c) of 6.8 [6.3-7.8]%, scheduled for aortic valve replacement. Valvular expression of AGEs, AGEs receptor (RAGE), interleukin-6 (IL-6), and reactive oxygen species (ROS) induction were evaluated ex vivo by immunostaining and calculated as the extent of positive immunoreactive areas/total sample area. Plasma levels of AGEs and soluble RAGE (sRAGE) were assessed by ELISAs. Results Subjects with DM had increased valvular expression of both AGEs (6.6-fold higher, 15.53 [9.96-23.28]%) and RAGE (1.8-fold higher, 6.8 [4.9-8.45]%) compared to nonDM patients (2.05 [1.21-2.58]% and 2.4 [1.56-3.02]%, respectively; both p < 0.001). Plasma levels of AGEs (12-fold higher) and sRAGE (1.3-fold higher) were elevated in DM patients, compared to nonDM (both p < 0.0001). The percentage of valvular ROS-positive (2.28 [1.6-3.09] vs. 1.15 [0.94-1.4]%, p < 0.0001) but not IL-6-positive areas was higher within DM, compared to nonDM valves. In DM patients, the percentage of valvular AGEs- and RAGE-positive areas correlated with HbA1c (r = 0.77, p < 0.0001 and r = 0.30, p = 0.034). Similarly, plasma AGEs and sRAGE levels were associated with HbA1c in the DM group (r = 0.32, p = 0.024 and r = 0.33, p = 0.014, respectively). In all DM patients, we found an association between the amount of valvular AGEs and the disease severity measured as aortic valve area (AVA; r = 0.68, p < 0.0001). Additionally, in DM patients with HbA1c > 7% (n = 24, 48%) we found that valvular expression of AGEs correlated with mean transvalvular pressure gradient (PG(mean); r = 0.45, p = 0.027). Plasma AGEs levels in the whole DM group correlated with AVA (r = - 0.32, p = 0.02), PG(mean)(r = 0.31, p = 0.023), and PG(max)(r = 0.30, p = 0.03). Conclusions Our study suggests that poorly-controlled diabetes leads to increased AGEs and RAGE valvular accumulation, which at least partially, might result in AS progression in DM patients.
C1 [Kopytek, Magdalena; Zabczyk, Michal; Mazur, Piotr; Undas, Anetta; Natorska, Joanna] John Paul 2 Hosp, Krakow, Poland.
   [Kopytek, Magdalena; Zabczyk, Michal; Mazur, Piotr; Undas, Anetta; Natorska, Joanna] Jagiellonian Univ, Coll Med, Inst Cardiol, 80 Pradnicka St, PL-31202 Krakow, Poland.
C3 Jagiellonian University; Collegium Medicum Jagiellonian University
RP Natorska, J (corresponding author), Jagiellonian Univ, Coll Med, Inst Cardiol, 80 Pradnicka St, PL-31202 Krakow, Poland.
EM j.natorska@szpitaljp2.krakow.pl
RI Natorska, Joanna/AHA-6096-2022; Ząbczyk, Michał/AHA-6044-2022; Kopytek,
   Magdalena/KHE-3603-2024
OI Kopytek, Magdalena/0000-0002-4026-8971; Zabczyk,
   Michal/0000-0003-1762-308X; Natorska, Joanna/0000-0003-3176-8007; Mazur,
   Piotr/0000-0003-4077-1232
FU Polish National Science Center [UMO-2015/19/B/NZ5/00647]
FX This study was supported by the grant from the Polish National Science
   Center (UMO-2015/19/B/NZ5/00647 to J.N).
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NR 37
TC 50
Z9 53
U1 0
U2 2
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1475-2840
J9 CARDIOVASC DIABETOL
JI Cardiovasc. Diabetol.
PD JUN 17
PY 2020
VL 19
IS 1
AR 92
DI 10.1186/s12933-020-01068-7
PG 12
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism
GA MB6NE
UT WOS:000542717800001
PM 32552684
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Kapila, YL
AF Kapila, Yvonne L.
TI Oral health's inextricable connection to systemic health: Special
   populations bring to bear multimodal relationships and factors
   connecting periodontal disease to systemic diseases and conditions
SO PERIODONTOLOGY 2000
LA English
DT Review
DE microbemias; oral health; periodontal disease; susceptible host;
   systemic disease; systemic inflammation
AB The landscape in dentistry is changing as emerging studies continue to reveal that periodontal health impacts systemic health, and vice versa. Population studies, clinical studies, and in vitro animal studies underscore the critical importance of oral health to systemic health. These inextricable relationships come to the forefront as oral diseases, such as periodontal disease, take root. Special populations bring to bear the multimodal relationships between oral and systemic health. Specifically, periodontal disease has been associated with diabetes, metabolic syndrome, obesity, eating disorders, liver disease, cardiovascular disease, Alzheimer disease, rheumatoid arthritis, adverse pregnancy outcomes, and cancer. Although bidirectional relationships are recognized, the potential for multiple comorbidities, relationships, and connections (multimodal relationships) also exists. Proposed mechanisms that mediate this connection between oral and systemic health include predisposing and precipitating factors, such as genetic factors (gene polymorphisms), environmental factors (stress, habits-such as smoking and high-fat diets/consumption of highly processed foods), medications, microbial dysbiosis and bacteremias/viremias/microbemias, and an altered host immune response. Thus, in a susceptible host, these predisposing and precipitating factors trigger the onset of periodontal disease and systemic disease/conditions. Further, high-throughput sequencing technologies are shedding light on the dark matter that comprises the oral microbiome. This has resulted in better characterization of the oral microbial dysbiosis, including putative bacterial periodontopathogens and shifts in oral virome composition during disease. Multiple laboratory and clinical studies have illustrated that both eukaryotic and prokaryotic viruses within subgingival plaque and periodontal tissues affect periodontal inflammation, putative periodontopathogens, and the host immune response. Although the association between herpesviruses and periodontitis and the degree to which these viruses directly aggravate periodontal tissue damage remain unclear, the benefits to periodontal health found from prolonged administration of antivirals in immunocompromised or immunodeficient individuals demonstrates that specific populations are possibly more susceptible to viral periodontopathogens. Thus, it may be important to further examine the implications of viral pathogen involvement in periodontitis and perhaps it is time to embrace the viral dark matter within the periodontal environment to fully comprehend the pathogenesis and systemic implications of periodontitis. Emerging data from the coronavirus disease 2019 pandemic further underscores the inextricable connection between oral and systemic health, with high levels of the severe acute respiratory syndrome coronavirus 2 angiotensin-converting enzyme 2 receptor noted on oral tissues (tongue) and an allostatic load or overload paradigm of chronic stress likely contributing to rapid breakdown of oral/dental, periodontal, and peri-implant tissues. These associations exist within a framework of viremias/bacteremias/microbemias, systemic inflammation, and/or disturbances of the immune system in a susceptible host. A thorough review of systemic and oral diseases and conditions and their mechanistic, predisposing, and precipitating factors are paramount to better addressing the oral and systemic health and needs of our patients.
C1 [Kapila, Yvonne L.] Univ Calif San Francisco, Sch Dent, Dept Orofacial Sci, San Francisco, CA 94143 USA.
C3 University of California System; University of California San Francisco
RP Kapila, YL (corresponding author), Univ Calif San Francisco, Sch Dent, Dept Orofacial Sci, San Francisco, CA 94143 USA.
EM yvonne.kapila@ucsf.edu
RI Kapila, Yvonne/AAG-5418-2021
OI Kapila, Yvonne/0000-0003-1330-0654
FU National Institute of Dental and Craniofacial Research [R01DE025225]
   Funding Source: NIH RePORTER; NIDCR NIH HHS [R01 DE025225] Funding
   Source: Medline
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NR 32
TC 194
Z9 207
U1 20
U2 120
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0906-6713
EI 1600-0757
J9 PERIODONTOL 2000
JI Periodontol. 2000
PD OCT
PY 2021
VL 87
IS 1
BP 11
EP 16
DI 10.1111/prd.12398
PG 6
WC Dentistry, Oral Surgery & Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dentistry, Oral Surgery & Medicine
GA UK2BO
UT WOS:000691780100003
PM 34463994
OA Green Published, Green Accepted, hybrid
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Kineman, RD
   del Rio-Moreno, M
   Waxman, DJ
AF Kineman, Rhonda D.
   del Rio-Moreno, Mercedes
   Waxman, David J.
TI Liver-specific actions of GH and IGF1 that protect against MASLD
SO NATURE REVIEWS ENDOCRINOLOGY
LA English
DT Review
ID GROWTH-HORMONE RECEPTOR; DIET-INDUCED OBESITY; FATTY LIVER; NONALCOHOLIC
   STEATOHEPATITIS; MOUSE-LIVER; BILE-ACID; HEPATOCELLULAR-CARCINOMA;
   INSULIN SENSITIVITY; SIGNAL TRANSDUCER; BODY-COMPOSITION
AB Metabolic dysfunction-associated steatotic liver disease (MASLD; also known as nonalcoholic fatty liver disease) is a chronic condition associated with metabolic syndrome, a group of conditions that includes obesity, insulin resistance, hyperlipidaemia and cardiovascular disease. Primary growth hormone (GH) deficiency is associated with MASLD, and the decline in circulating levels of GH with weight gain might contribute to the development of MASLD. Raising endogenous GH secretion or administering GH replacement therapy in the context of MASLD enhances insulin-like growth factor 1 (IGF1) production and reduces steatosis and the severity of liver injury. GH and IGF1 indirectly control MASLD progression by regulating systemic metabolic function. Evidence supports the proposal that GH and IGF1 also have a direct role in regulating liver metabolism and health. This Review focuses on how GH acts on the hepatocyte in a sex-dependent manner to limit lipid accumulation, reduce stress, and promote survival and regeneration. In addition, we discuss how GH and IGF1 might regulate non-parenchymal cells of the liver to control inflammation and fibrosis, which have a major effect on hepatocyte survival and regeneration. Development of a better understanding of how GH and IGF1 coordinate the functions of specific, individual liver cell types might provide insight into the aetiology of MASLD initiation and progression and suggest novel approaches for the treatment of MASLD.
   Growth hormone deficiency (GHD) is associated with metabolic dysfunction-associated steatotic liver disease (MASLD), and therapies that raise GH levels reduce steatosis and liver injury in patients with MASLD, in part mediated by the systemic metabolic actions of GH and insulin-like growth factor 1 (IGF1).The sex-dependent temporal patterns of pituitary release of GH are in part regulated by gonadal steroids and translate into sex-dependent patterns of activation of the hepatocyte transcription factor STAT5, which might help to explain the reduced risk of MASLD in women in premenopause.GH acts directly on hepatocytes to prevent excess lipid accumulation by shifting nutrient utilization from de novo lipogenesis to lipid oxidation, which is partly dependent on STAT5 signalling.GH-GH receptor (GHR)-STAT5 signalling regulates hepatocyte detoxification programmes that can prevent or ameliorate hepatocyte stress and death.GH-GHR-mediated STAT5-dependent and STAT5-independent pathways directly support hepatocyte survival and regeneration, including regulation of factors that modify the immune response.GH and IGF1 act on liver non-parenchymal cells to modify the inflammatory response, regenerative programmes and fibrosis progression.
   This Review discusses the roles of growth hormone (GH) and insulin-like growth factor 1 (IGF1) signalling in reducing the risk of metabolic dysfunction-associated steatotic liver disease (MASLD). Sex-dependent differences in MASLD susceptibility and the effects of GH and IGF1 on hepatocytes and non-parenchymal cells are considered.
C1 [Kineman, Rhonda D.; del Rio-Moreno, Mercedes] Univ Illinois, Dept Med, Sect Endocrinol Diabet & Metab, Chicago, IL 60607 USA.
   [Kineman, Rhonda D.; del Rio-Moreno, Mercedes] Jesse Brown VA Med Ctr, Res & Dev Div, Chicago, IL 60612 USA.
   [Waxman, David J.] Boston Univ, Dept Biol, Boston, MA USA.
   [Waxman, David J.] Boston Univ, Bioinformat Program, Boston, MA USA.
C3 University of Illinois System; University of Illinois Chicago;
   University of Illinois Chicago Hospital; US Department of Veterans
   Affairs; Veterans Health Administration (VHA); Jesse Brown VA Medical
   Center; Boston University; Boston University
RP Kineman, RD (corresponding author), Univ Illinois, Dept Med, Sect Endocrinol Diabet & Metab, Chicago, IL 60607 USA.; Kineman, RD (corresponding author), Jesse Brown VA Med Ctr, Res & Dev Div, Chicago, IL 60612 USA.
EM kineman@uic.edu
RI Kineman, Rhonda/H-2221-2011; del Rio-Moreno, Mercedes/M-8050-2019
OI Waxman, David/0000-0001-7982-9206
FU National Institutes of Health [DK116878, DK121998]; Veterans
   Administration [BX004448, BX005382]
FX The authors receive support from the National Institutes of Health
   (DK116878 to R.D.K. and DK121998 to D.J.W.) and Veterans Administration
   (BX004448 and BX005382 to R.D.K.).
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NR 208
TC 3
Z9 3
U1 9
U2 13
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 1759-5029
EI 1759-5037
J9 NAT REV ENDOCRINOL
JI Nat. Rev. Endocrinol.
PD FEB
PY 2025
VL 21
IS 2
BP 105
EP 117
DI 10.1038/s41574-024-01037-0
EA SEP 2024
PG 13
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA S2U9P
UT WOS:001319509300001
PM 39322791
DA 2025-06-11
ER

PT J
AU Thilavech, T
   Adisakwattana, S
   Channuwong, P
   Radarit, K
   Jantarapat, K
   Ngewlai, K
   Sonprasan, N
   Chusak, C
AF Thilavech, Thavaree
   Adisakwattana, Sirichai
   Channuwong, Pilailak
   Radarit, Korntima
   Jantarapat, Kanthida
   Ngewlai, Kittisak
   Sonprasan, Nantarat
   Chusak, Charoonsri
TI Clitoria ternatea Flower Extract Attenuates Postprandial Lipemia
   and Increases Plasma Antioxidant Status Responses to a High-Fat Meal
   Challenge in Overweight and Obese Participants
SO BIOLOGY-BASEL
LA English
DT Article
DE anthocyanins; Clitoria ternatea; high-fat meal; postprandial lipemia;
   antioxidant status
ID OXIDATIVE STRESS; METABOLIC SYNDROME; PANCREATIC LIPASE; INFLAMMATION;
   HYPERTRIGLYCERIDEMIA; MEN; ANTHOCYANINS; CONSUMPTION; OVERLOAD; LIPIDS
AB Simple Summary:& nbsp;Supplementation of high-fat meals with edible plants is the principal strategy to control postprandial dysmetabolism and inflammation. This study demonstrated that consumption of Clitoria ternatea flower extract (CTE) decreased postprandial serum triglyceride and serum free fatty acids, and improved plasma antioxidant status and glutathione peroxidase activity responses to a high-fat meal challenge in overweight and obese participants. However, CTE could not reduce the effect of HF meal-induced increase in postprandial glycemia and the level of pro-inflammatory cytokines. The findings of the present study suggest that CTE may be used as an effective ingredient to suppress postprandial lipemia and improve the antioxidant status in overweight and obese individuals that frequently consume HF diets.</p>
   </p>
   High-fat (HF) meal-induced postprandial lipemia, oxidative stress and low-grade inflammation is exacerbated in overweight and obese individuals. This postprandial dysmetabolism contributes to an increased risk of cardiovascular disease and metabolic disorders. Clitoria ternatea flower extract (CTE) possesses antioxidant potential and carbohydrate and fat digestive enzyme inhibitory activity in vitro. However, no evidence supporting a favorable role of CTE in the modulation of postprandial lipemia, antioxidant status and inflammation in humans presently exists. In the present study, we determine the effect of CTE on changes in postprandial glycemic and lipemic response, antioxidant status and pro-inflammatory markers in overweight and obese men after consumption of an HF meal. Following a randomized design, sixteen participants (age, 23.5 & PLUSMN; 0.6 years, and BMI, 25.7 & PLUSMN; 0.7 kg/m(2)) were assigned to three groups that consumed the HF meal, or HF meal supplemented by 1 g and 2 g of CTE. Blood samples were collected at fasting state and then at 30, 60, 90, 120, 180, 240, 300 and 360 min after the meal consumption. No significant differences were observed in the incremental area under the curve (iAUC) for postprandial glucose among the three groups. Furthermore, 2 g of CTE decreased the iAUC for serum triglyceride and attenuated postprandial serum free fatty acids at 360 min after consuming the HF meal. In addition, 2 g of CTE significantly improved the iAUC for plasma antioxidant status, as characterized by increased postprandial plasma FRAP and thiol levels. Postprandial plasma glutathione peroxidase activity was significantly higher at 180 min after the consumption of HF meal with 2 g of CTE. No significant differences in the level of pro-inflammatory cytokines (interleukin-6, interleukin-1 beta and tumor necrosis factor-a) were observed at 360 min among the three groups. These findings suggest that CTE can be used as a natural ingredient for reducing postprandial lipemia and improving the antioxidant status in overweight and obese men after consuming HF meals.</p>
C1 [Thilavech, Thavaree] Mahidol Univ, Dept Food Chem, Fac Pharm, Bangkok 10400, Thailand.
   [Adisakwattana, Sirichai; Channuwong, Pilailak; Chusak, Charoonsri] Chulalongkorn Univ, Fac Allied Hlth Sci, Dept Nutr & Dietet, Phytochem & Funct Food Res Unit Clin Nutr, Bangkok 10330, Thailand.
   [Radarit, Korntima; Jantarapat, Kanthida; Ngewlai, Kittisak; Sonprasan, Nantarat] Mahidol Univ, Fac Pharm, Program Doctor Pharm, Bangkok 10400, Thailand.
C3 Mahidol University; Chulalongkorn University; Mahidol University
RP Chusak, C (corresponding author), Chulalongkorn Univ, Fac Allied Hlth Sci, Dept Nutr & Dietet, Phytochem & Funct Food Res Unit Clin Nutr, Bangkok 10330, Thailand.
EM Thavaree.thi@mahidol.edu; Sirichai.a@chula.ac.th;
   6177051537@student.chula.ac.th; korntima.rad@student.mahidol.ac.th;
   Kanthida.jan@student.mahidol.ac.th; kittisak.nge@student.mahidol.ac.th;
   nantarat.son@student.mahidol.ac.th; charoonsri.c@chula.ac.th
RI Thilavech, Thavaree/AFS-9945-2022
OI Adisakwattana, Sirichai/0000-0002-7938-6561
FU Mahidol University [A9/2563]; National Research Council of Thailand
   (NRCT) [N42A640325]
FX This research project was supported by Mahidol University (A9/2563) and
   the National Research Council of Thailand (NRCT): N42A640325.
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NR 55
TC 11
Z9 12
U1 0
U2 4
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2079-7737
J9 BIOLOGY-BASEL
JI Biology-Basel
PD OCT
PY 2021
VL 10
IS 10
AR 975
DI 10.3390/biology10100975
PG 16
WC Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics
GA WN9ST
UT WOS:000712105700001
PM 34681074
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Kinnunen, PKJ
   Domanov, YA
   Mattila, JP
   Varis, T
AF Kinnunen, Paavo K. J.
   Domanov, Yegor A.
   Mattila, Juha-Pekka
   Varis, Teemu
TI Formation of lipid/peptide tubules by IAPP and temporin B on supported
   lipid membranes
SO SOFT MATTER
LA English
DT Article
ID ISLET AMYLOID POLYPEPTIDE; PHOSPHATIDYLSERINE-CONTAINING MEMBRANES;
   PROTEIN MISFOLDING DISEASES; OXIDATIVE STRESS; FIBRIL FORMATION;
   LEPTOSPIRA-INTERROGANS; PHOSPHOLIPID-BILAYERS; METABOLIC SYNDROME;
   PANCREATIC-ISLETS; SOLID-SURFACES
AB The conversion of various proteins and peptides to amyloid fibrils is accelerated by lipid membranes, which are also postulated to represent targets mediating the cytotoxicity of amyloid protofibrils. Yet, our understanding of the molecular details governing membrane-catalyzed fibrillogenesis of amyloid precursors remains limited. To obtain insight into the intricate interplay of amyloid growth and membrane biophysics we have recently introduced supported lipid bilayers (SLBs) with fluorescent lipid analogs as model biomembranes, observed by time-lapse confocal microscopy. Here we demonstrate that human islet amyloid polypeptide (IAPP) induces within minutes of its application on zwitterionic phosphatidylcholine bilayers the expulsion of numerous flexible lipid tubules from the SLB. Intriguingly, these flexible tubules gradually evolve into a network of straight tubes locally attached to the SLB substrate. Two-color imaging of the membrane and the fluorescently labeled peptide revealed IAPP to be distributed along the lipid tubes. Similar linear tubules were observed with the antimicrobial peptide temporin B and the non-amyloidogenic rat IAPP, revealing that the above mesoscopic membrane perturbations are not related to amyloid formation by the human IAPP. Micromanipulation experiments revealed that the linearity of the tubules was caused by tension, stretching the tubules between their points of attachment to the SLB substrate. After longer incubation times, for SLBs containing the oxidatively modified phospholipid 1-palmitoyl-2-azelaoyl-snglycero- 3-phosphocholine (PazePC, bearing a terminal carboxyl group at the end of the sn-2 azelaoyl chain) and human IAPP (but not the other peptides) some of the straight lipid tubes transformed into highly regular helices. This is likely to reflect tension originating from an efficient aggregation of the IAPP into parallelly aligned fibril bundles, associated with membrane tubes containing the oxidized phospholipid, possibly together with a concomitant flow of IAPP fibrils along the tubules to the immobile IAPP aggregates attaching the tubules to the SLB substrate, these two processes cause, upon shortening of the linear peptide scaffold, the attached excess lipid tubule to adopt a helical morphology, coiling around the peptide fibril core. The above fluorescence microscopy studies are in line with the multiphasic kinetics of IAPP fibrillation in the presence of oxidized lipid containing liposomes, assessed by thioflavin T fluorescence enhancement. In addition to demonstrating the feasibility of SLBs as biomimetic model system for studying lipid-assisted protein fibrillation, our results accentuate the role of membrane chemical composition in modulation of different stages of this process and the associated transformation of membrane architecture. Accordingly, changes in the chemical nature of cellular membranes arising from pathophysiological processes such as oxidative stress may participate in the triggering amyloidogenesis as well as amplification of its detrimental effects in vivo.
C1 [Kinnunen, Paavo K. J.; Domanov, Yegor A.; Mattila, Juha-Pekka; Varis, Teemu] Univ Helsinki, Med Biochem Inst Biomed, Helsinki Biophys & Biomembrane Grp, FIN-00014 Helsinki, Finland.
C3 University of Helsinki
RP Kinnunen, PKJ (corresponding author), Univ Helsinki, Med Biochem Inst Biomed, Helsinki Biophys & Biomembrane Grp, POB 63 Haartmaninkatu 8, FIN-00014 Helsinki, Finland.
EM paavo.kinnunen@helsinki.fi
OI Domanov, Yegor/0000-0003-1531-6457
FU EUROCORES Programme EUROMEMBRANE, European Science Foundation; Finnish
   Academy; Sigrid Juselius Foundation; European Commission (Marie Curie
   International Fellowship); FP6 (Nanoear); FP7 (Sonodrugs); Kibron Inc.
FX The authors thank Kristiina Soderlund for skillful assistance and Karen
   Sabatini, PhD, for her help in the acquisition of some of the image
   sequences. HBBG is supported by grants from the EUROCORES Programme
   EUROMEMBRANE by European Science Foundation (www.esf.org/euromembrane),
   Finnish Academy, the Sigrid Juselius Foundation, European Commission
   (Marie Curie International Fellowship, Y.A.D.), FP6 (Nanoear), FP7
   (Sonodrugs), and Kibron Inc. (K.S.).
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NR 53
TC 12
Z9 12
U1 0
U2 15
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 1744-683X
EI 1744-6848
J9 SOFT MATTER
JI Soft Matter
PY 2015
VL 11
IS 47
BP 9188
EP 9200
DI 10.1039/b925228b
PG 13
WC Chemistry, Physical; Materials Science, Multidisciplinary; Physics,
   Multidisciplinary; Polymer Science
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Materials Science; Physics; Polymer Science
GA CX0SQ
UT WOS:000365407500014
PM 26575388
DA 2025-06-11
ER

PT J
AU Krajewska, M
   Witkowska-Sedek, E
   Ruminska, M
   Kucharska, AM
   Stelmaszczyk-Emmel, A
   Sobol, M
   Majcher, A
   Pyrzak, B
AF Krajewska, Maria
   Witkowska-Sedek, Ewelina
   Ruminska, Malgorzata
   Kucharska, Anna M.
   Stelmaszczyk-Emmel, Anna
   Sobol, Maria
   Majcher, Anna
   Pyrzak, Beata
TI The link between vitamin D, chemerin and metabolic profile in overweight
   and obese children-preliminary results
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Article
DE obesity; children; vitamin D; chemerin; C-reactive protein; glucose;
   insulin; lipid profile
ID CARDIOMETABOLIC RISK-FACTORS; INSULIN-RESISTANCE; D DEFICIENCY; SERUM
   CHEMERIN; CHILDHOOD OBESITY; D INSUFFICIENCY; ADIPOSE-TISSUE;
   ASSOCIATION; ADOLESCENTS; MARKERS
AB Background: Vitamin D affects adipogenesis, oxidative stress, inflammation, secretion of adipocytokines, lipid metabolism and thermogenesis. Some researchers postulate that those effects could be exerted by the influence of vitamin D on chemerin levels.
   Aim of the study: We aimed to investigate if there is a link between serum 25-hydroksyvitamin D [25(OH)D], chemerin and metabolic profile in overweight and obese children before and after vitamin D supplementation.
   Material and methods: The prospective study included 65 overweight and obese children aged 9.08-17.5 years and 26 peers as a control. None of the patients in the study group had received vitamin D within the last twelve months before the study.
   Results: The study group had lower baseline 25(OH)D (p<0.001) and higher chemerin (p<0.001), triglycerides (TG, p<0.001), triglycerides/ high density lipoprotein cholesterol ( TG/HDL-C, p< 0.001), C- reactive protein (CRP, p<0.05), fasting insulin (p<0.001), Homeostasis Model Assessment - Insulin Resistance (HOMA-IR, p<0.001), alanine aminotransferase (ALT, p<0.001) and uric acid (p<0.001) compared to the control group. Baseline vitamin D was related to fasting insulin (R=-0.29, p=0.021), HOMA-IR (R=-0.30, p=0.016), HDL-C (R=0.29, p=0.020) and uric acid (R=-0.28, p=0.037) in the study group. Baseline chemerin was related to insulin at 30' (R=0.27, p=0.030), 60' (R=0.27, p=0.033), 90' (R=0.26, p=0.037) and 120' (R=0.26, p=0.040) during the oral glucose tolerance test (OGTT) and ALT (R=0.25, p=0.041) in the study group. Correlation between vitamin D and chemerin (R=-0.39, p=0.046) was found only in the control group. After six months of vitamin D supplementation a decrease in CRP (p<0.01), total cholesterol (p<0.05), ALT (p<0.01), glucose at 150' OGTT (p<0.05) was observed. Moreover, we noticed a tendency for negative association between 25(OH)D and chemerin levels ( p=0.085). Multivariable backward linear regression models were build using baseline vitamin D, baseline chemerin and six months chemerin as the dependent variables.
   Conclusions: Our study confirmed that vitamin D has positive effect on metabolic profile in overweight and obese children. The relationship between vitamin D and chemerin is not clear, nevertheless we have observed a tendency to decrease chemerin concentrations after improving vitamin D status, even without a significant reduction in body fat mass.
C1 [Krajewska, Maria; Witkowska-Sedek, Ewelina; Ruminska, Malgorzata; Kucharska, Anna M.; Majcher, Anna; Pyrzak, Beata] Med Univ Warsaw, Dept Paediat & Endocrinol, Warsaw, Poland.
   [Stelmaszczyk-Emmel, Anna] Med Univ Warsaw, Dept Lab Diagnost & Clin Immunol Dev Age, Warsaw, Poland.
   [Sobol, Maria] Med Univ Warsaw, Dept Biophys Physiol & Pathophysiol, Warsaw, Poland.
C3 Medical University of Warsaw; Medical University of Warsaw; Medical
   University of Warsaw
RP Krajewska, M (corresponding author), Med Univ Warsaw, Dept Paediat & Endocrinol, Warsaw, Poland.
EM mkrajewska@wum.edu.pl
RI Kucharska, Anna/U-8957-2018; Rumińska, Małgorzata/T-8225-2018; Pyrzak,
   Beata/U-6048-2018; Stelmaszczyk-Emmel, Anna/O-3297-2014;
   Witkowska-Sedek, Ewelina/T-8223-2018
OI Pyrzak, Beata/0000-0001-8914-7815; Stelmaszczyk-Emmel,
   Anna/0000-0003-3667-1220; Witkowska-Sedek, Ewelina/0000-0002-6022-9478;
   Sobol, Maria/0000-0002-5105-0687; Majcher, Anna/0000-0002-6115-5044;
   Kucharska, Anna/0000-0002-1714-7709
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NR 79
TC 2
Z9 2
U1 0
U2 5
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD APR 20
PY 2023
VL 14
AR 1143755
DI 10.3389/fendo.2023.1143755
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA F1FQ0
UT WOS:000979878000001
PM 37152969
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Vors, C
   Rancourt-Bouchard, M
   Couillard, C
   Gigleux, I
   Couture, P
   Lamarche, B
AF Vors, Cecile
   Rancourt-Bouchard, Maryka
   Couillard, Charles
   Gigleux, Iris
   Couture, Patrick
   Lamarche, Benoit
TI Sex May Modulate the Effects of Combined Polyphenol Extract and
   L-citrulline Supplementation on Ambulatory Blood Pressure in Adults with
   Prehypertension: A Randomized Controlled Trial
SO NUTRIENTS
LA English
DT Article
DE polyphenols; grape seeds; cranberries; L-citrulline; antioxidants;
   hypertension; cardiovascular diseases; glycation end products;
   endothelial function
ID GLYCATION END-PRODUCTS; GRAPE SEED EXTRACT; C-REACTIVE PROTEIN; SKIN
   AUTOFLUORESCENCE; METABOLIC SYNDROME; DOUBLE-BLIND; DIETARY PATTERNS;
   OXIDATIVE STRESS; SURROGATE MARKER; NITRIC-OXIDE
AB Increased blood pressure (BP), vascular dysfunction and inflammation are involved in the etiology of cardiovascular disease (CVD). Although several dietary components such as polyphenols and L-citrulline may help to control BP, their combined impact on ambulatory BP in individuals at risk of CVD remains unknown. The objective of this research was to investigate the short-term impact of supplementation with a combination of polyphenol extract and L-citrulline on ambulatory BP, endothelial function and inflammation. In a randomized double-blind parallel trial, 73 men and women with prehypertension were supplemented with a placebo (cellulose, n = 34, Plac) or 548 mg/day of polyphenols and 2 g/day of L-citrulline (n = 35, Suppl) for 6 weeks. The primary outcome of this study was the difference between groups in 24-h ambulatory diastolic BP (DBP) at week six. Secondary outcomes were a difference between groups at week six in ambulatory systolic BP (SBP), casual BP, serum lipids and high-sensitivity C-reactive protein (hs-CRP) concentrations and skin advanced glycation end products (AGEs). Potential interaction of treatment with sex was examined. Suppl had no impact on mean ambulatory SBP and DBP (p > 0.10 vs. placebo). Daytime and 24-h SBP were reduced with Suppl in women (p <= 0.01), but not in men (p >= 0.27). A non-significant reduction in AGEs was observed after Suppl compared to Plac among all participants (p = 0.07) and there was no difference in the concentrations of blood lipids (p > 0.20) or CRP (p = 0.36) between treatments at week six. Therefore, supplementation with polyphenol extract and L-citrulline for 6 weeks has no impact on ambulatory BP, blood lipids and CRP in adults with prehypertension. However, the polyphenol extract/L-citrulline supplement may reduce ambulatory SBP in women, but not in men. These preliminary results need further research efforts towards further documenting this sex-dependent BP response to supplementation with polyphenols and L-citrulline.
C1 [Vors, Cecile; Rancourt-Bouchard, Maryka; Couillard, Charles; Gigleux, Iris; Couture, Patrick; Lamarche, Benoit] Univ Laval, Ctr Nutr Sante & Soc NUTRISS, Inst Nutr & Aliments Fonct INAF, Quebec City, PQ G1V 0A6, Canada.
   [Couture, Patrick] Univ Laval, CHU Quebec Res Ctr, Quebec City, PQ G1V 0A6, Canada.
C3 Laval University; Laval University
RP Vors, C (corresponding author), Univ Laval, Ctr Nutr Sante & Soc NUTRISS, Inst Nutr & Aliments Fonct INAF, Quebec City, PQ G1V 0A6, Canada.
EM cecile.vors@univ-lyon1.fr; maryka.rancourt-bouchard@fsaa.ulaval.ca;
   Charles.Couillard@fsaa.ulaval.ca; Iris.Gigleux@fsaa.ulaval.ca;
   patrick.couture@crchul.ulaval.ca; Benoit.Lamarche@fsaa.ulaval.ca
RI ; Vors, Cecile/M-8487-2018
OI Couillard, Charles/0000-0002-6281-8663; Lab, Carmen/0000-0002-5935-3236;
   Carmen, Team1/0000-0003-4234-1746; Vors, Cecile/0000-0002-5595-7833
FU Atrium Innovations; Canadian Institutes for Health Research; Agriculture
   and Agri-Food Canada (Growing Forward program - Dairy Farmers of
   Canada); Agriculture and Agri-Food Canada (Canola Council of Canada);
   Agriculture and Agri-Food Canada (Flax Council of Canada); Agriculture
   and Agri-Food Canada (Dow Agrosciences); Dairy Research Institute; Dairy
   Australia; Danone Institute; Merck Frosst; Pfizer; Amgen; Sanofi; Kaneka
   Corporation; National Mango Board; National Processed Raspberry Council;
   U.S. Highbush Blueberry Council; Atrium Innovations between 2012 and
   2019
FX This RCT was supported by Atrium Innovations. The supplements of
   polyphenol extract and L-citrulline as well as the placebo were supplied
   by Pure Encapsulations. B.L. received research funding from Atrium
   Innovations between 2012 and 2019, including funding for the trial
   described in this paper. P.C. received funding during the past 5 years
   from the Canadian Institutes for Health Research, Agriculture and
   Agri-Food Canada (Growing Forward program supported by the Dairy Farmers
   of Canada, Canola Council of Canada, Flax Council of Canada, and Dow
   Agrosciences), Dairy Research Institute, Dairy Australia, Danone
   Institute, Merck Frosst, Pfizer, Amgen, Sanofi, Kaneka Corporation, and
   Atrium Innovations. C.C. has received funding in the last 5 years from
   the Canadian Institutes for Health Research, National Mango Board,
   National Processed Raspberry Council, U.S. Highbush Blueberry Council.
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NR 60
TC 6
Z9 6
U1 0
U2 3
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD FEB
PY 2021
VL 13
IS 2
AR 399
DI 10.3390/nu13020399
PG 14
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA QO1ME
UT WOS:000622910100001
PM 33513929
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Zhang, YH
   Hu, M
   Jia, WY
   Liu, GQ
   Zhang, J
   Wang, B
   Li, J
   Cui, P
   Li, X
   Lager, S
   Sferruzzi-Perri, AN
   Han, YH
   Liu, SJ
   Wu, XK
   Brännström, M
   Shao, LR
   Billig, H
AF Zhang, Yuehui
   Hu, Min
   Jia, Wenyan
   Liu, Guoqi
   Zhang, Jiao
   Wang, Bing
   Li, Juan
   Cui, Peng
   Li, Xin
   Lager, Susanne
   Sferruzzi-Perri, Amanda Nancy
   Han, Yanhua
   Liu, Songjiang
   Wu, Xiaoke
   Brannstrom, Mats
   Shao, Linus R.
   Billig, Hakan
TI Hyperandrogenism and insulin resistance modulate gravid uterine and
   placental ferroptos's in PCOS-like rats
SO JOURNAL OF ENDOCRINOLOGY
LA English
DT Article
DE ferroptosis; mitochondria; gravid uterus; placenta; PCOS
ID OVARY-SYNDROME PCOS; GLUTATHIONE-PEROXIDASE; METABOLIC SYNDROME;
   OXIDATIVE STRESS; PREGNANT-WOMEN; CELL-DEATH; ASSOCIATION; DYSFUNCTION;
   SELENIUM; SYSTEM
AB Women with polycystic ovary syndrome (PCOS) have hyperandrogenism and insulin resistance and a high risk of miscarriage during pregnancy. Similarly, in rats, maternal exposure to 5 alpha-dihydrotestosterone (DHT) and insulin from gestational day 7.5 to 13.5 leads to hyperandrogenism and insulin resistance and subsequently increased fetal loss. A variety of hormonal and metabolic stimuli are able to trigger different types of regulated cell death under physiological and pathological conditions. These include ferroptosis, apoptosis and necroptosis. We hypothesized that, in rats, maternal hyperandrogenism and insulin-resistance-induced fetal loss is mediated, at least in part, by changes in the ferroptosis, apoptosis and necroptosis pathways in the gravid uterus and placenta. Compared with controls, we found that co-exposure to DHT and insulin led to decreased levels of glutathione peroxidase 4 (GPX4) and glutathione, increased glutathione + glutathione disulfide and malondialdehyde, aberrant expression of ferroptosis-associated genes (Acsl4, Tfrc, Slc7a11, and Gclc), increased iron deposition and activated ERK/p38/JNK phosphorylation in the gravid uterus. In addition, we observed shrunken mitochondria with electron-dense cristae, which are key features of ferroptosis-related mitochondrial morphology, as well as increased expression of Dpp4, a mitochondria-encoded gene responsible for ferroptosis induction in the uteri of rats co-exposed to DHT and insulin. However, in the placenta, DHT and insulin exposure only partially altered the expression of ferroptosis-related markers (e.g. region-dependent GPX4, glutathione + glutathione disulfide, malondialdehyde, Gls2 and Slc7a11 mRNAs, and phosphorylated p38 levels). Moreover, we found decreased expression of Dpp4 mRNA and increased expression of Cisdl mRNA in placentas of rats co-exposed to DHT and insulin. Further, DHT+ insulin-exposed pregnant rats exhibited decreased apoptosis in the uterus and increased necroptosis in the placenta. Our findings suggest that maternal hyperandrogenism and insulin resistance causes the activation of ferroptosis in the gravid uterus and placenta, although this is mediated via different mechanisms operating at the molecular and cellular levels. Our data also suggest that apoptosis and necroptosis may play a role in coordinating or compensating for hyperandrogenism and insulin-resistance-induced ferroptosis when the gravid uterus and placenta are dysfunctional.
C1 [Zhang, Yuehui; Jia, Wenyan; Liu, Guoqi; Wang, Bing; Han, Yanhua; Liu, Songjiang; Wu, Xiaoke] Heilongjiang Univ Chinese Med, Affiliated Hosp 1, Key Lab, Dept Obstet & Gynecol, Harbin, Peoples R China.
   [Zhang, Yuehui; Jia, Wenyan; Liu, Guoqi; Wang, Bing; Han, Yanhua; Liu, Songjiang; Wu, Xiaoke] Heilongjiang Univ Chinese Med, Affiliated Hosp 1, Unit Infertil Chinese Med, Harbin, Peoples R China.
   [Hu, Min; Li, Juan; Cui, Peng; Li, Xin; Shao, Linus R.; Billig, Hakan] Univ Gothenburg, Sahlgrenska Acad, Inst Neurosci & Physiol, Dept Physiol Endocrinol, Gothenburg, Sweden.
   [Hu, Min; Li, Juan] Guangzhou Med Univ, Dept Tradit Chinese Med, Affiliated Hosp 1, Guangzhou, Peoples R China.
   [Zhang, Jiao] Heilongjiang Univ Chinese Med, Affiliated Hosp 2, Dept Acupuncture & Moxibust, Harbin, Peoples R China.
   [Cui, Peng] Shanghai Univ Tradit Chinese Med, Dept Gynecol, Shuguang Hosp, Shanghai, Peoples R China.
   [Li, Xin] Fudan Univ, Dept Gynecol, Obstet & Gynecol Hosp, Shanghai, Peoples R China.
   [Li, Xin] Shanghai Key Lab Female Reprod Endocrine Related, Shanghai, Peoples R China.
   [Lager, Susanne] Uppsala Univ, Dept Womens & Childrens Hlth, Uppsala, Sweden.
   [Sferruzzi-Perri, Amanda Nancy] Univ Cambridge, Dept Physiol Dev & Neurosci, Ctr Trophoblast Res, Cambridge, England.
   [Brannstrom, Mats] Univ Gothenburg, Sahlgrenska Univ Hosp, Sahlgrenska Acad, Dept Obstet & Gynecol, Gothenburg, Sweden.
C3 Heilongjiang University of Chinese Medicine; Heilongjiang University of
   Chinese Medicine; University of Gothenburg; Guangzhou Medical
   University; Heilongjiang University of Chinese Medicine; Shanghai
   University of Traditional Chinese Medicine; Fudan University; Shanghai
   Academy of Science & Technology; Uppsala University; University of
   Cambridge; Sahlgrenska University Hospital; University of Gothenburg
RP Shao, LR (corresponding author), Univ Gothenburg, Sahlgrenska Acad, Inst Neurosci & Physiol, Dept Physiol Endocrinol, Gothenburg, Sweden.
EM ruijin.shao@fysiologi.gu.se
RI wu, jialin/JPY-4408-2023; Zhang, Yuehui/H-7821-2013; Shao,
   Linus/M-3134-2019; Lager, Susanne/O-4193-2017
OI Shao, Linus/0000-0002-1339-9570; Sferruzzi-Perri,
   Amanda/0000-0002-4931-4233; Zhang, Yuehui/0000-0001-8517-7603; Cui,
   Peng/0000-0002-4566-6223; Hu, Min/0000-0002-7731-5874; Lager,
   Susanne/0000-0003-3556-065X
FU Swedish Medical Research Council [10380]; Swedish government
   [ALFGBG-147791]; Swedish county councils -the ALF [ALFGBG-147791]; Jane
   and Dan Olsson's Foundation; Knut and Alice Wallenberg Foundation;
   Adlerbert Research Foundation; National Natural Science Foundation of
   China [81774136]; Project of Young Innovation Talents in Heilongjiang
   Provincial University [UNPYSCT-2015121]; Scientific Research Foundation
   for Postdoctoral Researchers of Heilong Jiang Province; Project of
   Science Foundation by Heilongjiang University of Chinese Medicine;
   Project of Excellent Innovation Talents by Heilongjiang University of
   Chinese Medicine; Guangzhou Medical University High-level University
   Construction Talents Fund [B185006010046]; Royal Society Dorothy Hodgkin
   Research Fellowship; MRC [MR/R022690/1] Funding Source: UKRI
FX This study was financed by grants from the Swedish Medical Research
   Council (grant number 10380), the Swedish state under the agreement
   between the Swedish government and the county councils -the ALF
   agreement (grant number ALFGBG-147791), Jane and Dan Olsson's
   Foundation, the Knut and Alice Wallenberg Foundation, and the Adlerbert
   Research Foundation to HB and LRS as well as the National Natural
   Science Foundation of China (Grant No. 81774136), the Project of Young
   Innovation Talents in Heilongjiang Provincial University (Grant
   No.UNPYSCT-2015121), the Scientific Research Foundation for Postdoctoral
   Researchers of Heilong Jiang Province, the Project of Science Foundation
   by Heilongjiang University of Chinese Medicine, and the Project of
   Excellent Innovation Talents by Heilongjiang University of Chinese
   Medicine to YZ. The Guangzhou Medical University High-level University
   Construction Talents Fund (grant number B185006010046) supported MH.
   ANSP is supported by a Royal Society Dorothy Hodgkin Research
   Fellowship.
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NR 62
TC 82
Z9 89
U1 2
U2 65
PU BIOSCIENTIFICA LTD
PI BRISTOL
PA STARLING HOUSE, 1600 BRISTOL PARKWAY N, BRISTOL, ENGLAND
SN 0022-0795
EI 1479-6805
J9 J ENDOCRINOL
JI J. Endocrinol.
PD SEP
PY 2020
VL 246
IS 3
BP 247
EP 263
DI 10.1530/JOE-20-0155
PG 17
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA NK0DV
UT WOS:000566413300008
PM 32590339
OA Bronze
DA 2025-06-11
ER

PT J
AU Goon, MDME
   Zulkanain, NI
   Kadir, SHSA
   Ab Rahim, S
   Mazlan, M
   Abd Latip, N
   Aziz, MA
   Noor, NM
AF Goon, Mohd Danial Mohd Efendy
   Zulkanain, Nur Izzati
   Kadir, Siti Hamimah Sheikh Abdul
   Ab Rahim, Sharaniza
   Mazlan, Musalmah
   Abd Latip, Normala
   Aziz, Mardiana Abdul
   Noor, Norizal Mohd
TI Palm tocotrienol rich fraction with palm kernel oil supplementation
   prevents development of liver steatosis in high fat diet ICR mice
SO TRANSLATIONAL GASTROENTEROLOGY AND HEPATOLOGY
LA English
DT Article
DE Tocotrienol; anti-oxidant; fatty liver; medium-chain triglycerides;
   inbred ICR mice
ID LONG-CHAIN TRIGLYCERIDES; VITAMIN-E; METABOLIC SYNDROME; DISEASE;
   ASSOCIATION; OBESITY
AB Background: The prevalence of non-alcoholic fatty liver disease (NAFLD) in Asian countries is increasing at concerning level. Currently, no specific treatment available to prevent its oxidative stress and progression except for diet and lifestyle changes. Vitamin E such as tocotrienol-rich fraction (TRF) has a promising potential in preventing NAFLD progression. TRF is a potent antioxidant but has low bioavailability due u) the use of long-chain triglycerides (LCT) as its carrier. Testing of potential therapeutic agents such as TRF are commonly carried out using animal models. These animal models are often costly due to limited access to the supply especially Asian countries and predisposed to high transportation cost. Lower expenditure of NAFLD model should be investigated without forfeiting the outcome of study. Therefore, this study addresses the gap by utilizing the ICR mice as NAFLD model through dietary modification and testing on the newly formulated TRF with combination of palm kernel oil (PKO) as a medium-chain triglycerides (MCT) carrier.
   Methods: Fifteen ICR strain mice were randomly group into two control and one treatment group. Control groups received high-fat diet (HFD) only and standard diet while treatment group was given HFD with TRF (200 mg/kg/day). Study was carried out for 10 weeks. Weights were recorded twice a week. At the end of study, all mice were euthanized and data such weights, waist circumference and random blood glucose were recorded. Liver from each mouse were prepared for histology assessment.
   Results: Mice mean weights and random blood sugar showed no difference between group (P>0.05) while significance waist circumference was larger in HFD and TRF groups compared to SD (P<0.05). Histology assessment showed steatosis in TRF group had lower severity compared to HFD group. NAFLD activity score (NAS) was lower in treatment group compared to HFD group.
   Conclusions: TRF showed promising potential as an agent to reduce NAFLD progression in ICR mice. Further study at gene and protein levels are required to fully elucidate the mechanism of this new TRF formulation in reducing NAFLD progression.
C1 [Goon, Mohd Danial Mohd Efendy; Zulkanain, Nur Izzati; Kadir, Siti Hamimah Sheikh Abdul; Ab Rahim, Sharaniza; Mazlan, Musalmah] Univ Teknol MARA UiTM, Fac Med, Dept Biochem, Sungai Buloh 47000, Selangor, Malaysia.
   [Goon, Mohd Danial Mohd Efendy; Zulkanain, Nur Izzati; Kadir, Siti Hamimah Sheikh Abdul] Univ Teknol MARA UiTM, Inst Pathol, Lab & Forensies I PPerForM, Sungai Buloh, Selangor, Malaysia.
   [Goon, Mohd Danial Mohd Efendy; Kadir, Siti Hamimah Sheikh Abdul] Univ Teknol MARA UiTM, Fac Med, Inst Mol Med Biotechnol, Sungai Buloh, Selangor, Malaysia.
   [Abd Latip, Normala] Univ Teknol MARA UiTM, Fac Pharm, Atta Ur Rahman Inst Nat Prod Discovery AuRIns, Sungai Buloh, Selangor, Malaysia.
   [Aziz, Mardiana Abdul; Noor, Norizal Mohd] Univ Teknol MARA UiTM, Fac Med, Dept Pathol, Sungai Buloh, Selangor, Malaysia.
RP Kadir, SHSA (corresponding author), Univ Teknol MARA UiTM, Fac Med, Dept Biochem, Sungai Buloh 47000, Selangor, Malaysia.
EM sitih587@salam.uitm.edu.my
RI Mazlan, Musalmah/AAP-8496-2020; Mohd Efendy Goon, Mohd
   Danial/AIE-9937-2022; Noor, Norizal/ABC-5376-2020; Sheikh Abdul Kadir,
   Siti Hamimah/ABA-7769-2021; Abd Latip, Normala/O-1425-2017
OI Abd Latip, Normala/0000-0003-4957-5369
FU MITRA Perdana Grant [600-IRMI/PERDANA 5/3/MITRA (007-2018)-2]; Research
   Initiative Grant (GIP) through Universiti Teknologi MARA (UiTM,
   Malaysia) from the Malaysian government (Ministry of Higher Education)
   [600-IRMI/5/3/GIP (053/2018)]
FX This study was funded by the MITRA Perdana Grant [600-IRMI/PERDANA
   5/3/MITRA (007-2018)-2] and Research Initiative Grant (GIP)
   [600-IRMI/5/3/GIP (053/2018)] through Universiti Teknologi MARA (UiTM,
   Malaysia) from the Malaysian government (Ministry of Higher Education).
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NR 34
TC 2
Z9 2
U1 1
U2 4
PU AME PUBL CO
PI SHATIN
PA FLAT-RM C 16F, KINGS WING PLAZA 1, NO 3 KWAN ST, SHATIN, HONG KONG
   00000, PEOPLES R CHINA
EI 2415-1289
J9 TRANSL GASTROENT HEP
JI Transl. Gastroenterol. Hepatol.
PD JAN
PY 2022
VL 7
AR 2
DI 10.21037/tgh.2020.02.20
EA FEB 2020
PG 9
WC Gastroenterology & Hepatology
WE Emerging Sources Citation Index (ESCI)
SC Gastroenterology & Hepatology
GA ZS9GL
UT WOS:000675480900001
PM 35243111
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Wu, T
   Jiang, JG
   Yang, LN
   Li, HF
   Zhang, WJ
   Chen, YY
   Zhao, BG
   Kong, BD
   Lu, P
   Zhao, ZZ
   Zhu, JW
   Fu, ZW
AF Wu, Tao
   Jiang, Jianguo
   Yang, Luna
   Li, Haifeng
   Zhang, Wanjing
   Chen, Yangyang
   Zhao, Binggong
   Kong, Boda
   Lu, Ping
   Zhao, Zhenzhen
   Zhu, Jiawei
   Fu, Zhengwei
TI Timing of glucocorticoid administration determines severity of lipid
   metabolism and behavioral effects in rats
SO CHRONOBIOLOGY INTERNATIONAL
LA English
DT Article
DE Glucocorticoids; GR; lipid accumulation; locomotor activity; timing
ID CIRCADIAN GENE-EXPRESSION; CUSHINGS-SYNDROME; CHRONIC STRESS;
   PPAR-ALPHA; DEXAMETHASONE; SIGNALS; INSULIN; PROTEIN; CLOCK; MICE
AB Glucocorticoids (GCs) are a group of steroid hormones secreted by the adrenal glands in circadian cycles, and the dysregulation of GC signaling has been suggested to cause metabolic syndrome. Even though prolonged GC exposure is associated with serious side effects such asmetabolic syndromeand central nervous system disorders, the use of GCs in anti-inflammatory and immunosuppressive therapies has been continuously rising. Meanwhile, the exact mechanisms by which GCs can influence the lipid metabolism as well as behavior and how they are affected by time remain unknown. In this study, the effects of two different long-term GC dosing regimens on lipid metabolism and behavior were investigated. Male Wistar rats received daily administrations of the GC dexamethasone sodium phosphate (DEX, 0.5 mg/kg body weight) at either ZT0 (Dex0) or ZT12 (Dex12). After 6 weeks of treatment, DEX-treated rats, especially those treated at ZT0, had higher hepatic lipid accumulation and serum triglyceride levels and less locomotor activity than did control rats. In addition, serum levels of corticosterone, 5-hydroxy tryptamine and norepinephrine were decreased in the Dex0 group but not in the Dex12 group compared to the control group. Furthermore, quantitative real-time polymerase chain reaction analysis indicated that the chronic administration of GCs at ZT0 upregulated genes related to glycolysis and lipid synthesis and downregulated genes related to fatty acid beta-oxidation in the liver more remarkably than administration at ZT12. Both DEX-treated groups displayed severely altered expression patterns of the core clock genes Bmal1 and Per2 in the liver and in fat. In addition, the expression of glutamate aspartate transporter, glial fibrillary acidic protein and glutamate transporter- 1, astrocyte-related genes important for maintaining nervous system functions, was drastically decreased in the hippocampus of DEX-treated rats, especially when DEX was given at ZT0. In conclusion, our findings confirm that the severity of side effects, indicated by altered lipid metabolism and behavioral activity, depends on the timing of GC administration and is associated with the degree of glucocorticoid receptor dysfunction after dosing at disparate time points.
C1 [Wu, Tao; Jiang, Jianguo; Yang, Luna; Zhang, Wanjing; Chen, Yangyang; Zhao, Binggong; Kong, Boda; Lu, Ping; Zhao, Zhenzhen; Zhu, Jiawei; Fu, Zhengwei] Zhejiang Univ Technol, Coll Biotechnol & Bioengn, 6 Dist, Hangzhou 310032, Zhejiang, Peoples R China.
   [Li, Haifeng] Zhejiang Univ, Sch Med, Childrens Hosp, Hangzhou, Zhejiang, Peoples R China.
C3 Zhejiang University of Technology; Zhejiang University
RP Fu, ZW (corresponding author), Zhejiang Univ Technol, Coll Biotechnol & Bioengn, 6 Dist, Hangzhou 310032, Zhejiang, Peoples R China.
EM azwfu@zjut.edu.cn
RI Chen, Yangyang/K-4388-2016; Jiang, Yueming/AAJ-5538-2020; Wu,
   Tao/A-7783-2012; Fu, Zhengwei/G-3162-2011
OI Fu, Zhengwei/0000-0003-3351-3075
FU National Natural Science Foundation of China [31200890]; Open Research
   Fund Program of Collaborative Innovation Center of Membrane Separation
   and Water Treatment, Zhejiang Province Public Welfare Research Project
   [2015C33178]; Scientific Innovation Program for University Students in
   Zhejiang Province [2014R403060]
FX This work was supported by a grant from the National Natural Science
   Foundation of China (grant number 31200890), the Open Research Fund
   Program of Collaborative Innovation Center of Membrane Separation and
   Water Treatment, Zhejiang Province Public Welfare Research Project
   (grant number 2015C33178) and the Scientific Innovation Program for
   University Students in Zhejiang Province (grant number 2014R403060).
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NR 62
TC 24
Z9 27
U1 0
U2 3
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 0742-0528
EI 1525-6073
J9 CHRONOBIOL INT
JI Chronobiol. Int.
PY 2017
VL 34
IS 1
BP 78
EP 92
DI 10.1080/07420528.2016.1238831
PG 15
WC Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics; Physiology
GA EO5JA
UT WOS:000396728000007
PM 27791398
DA 2025-06-11
ER

PT J
AU Romero, MD
   Fernández-López, JA
   Esteve, M
   Alemany, M
AF del Mar Romero, Maria
   Antonio Fernandez-Lopez, Jose
   Esteve, Montserrat
   Alemany, Maria
TI Different modulation by dietary restriction of adipokine expression in
   white adipose tissue sites in the rat
SO CARDIOVASCULAR DIABETOLOGY
LA English
DT Article
ID ORAL OLEOYL-ESTRONE; INSULIN-RESISTANCE; GENE-EXPRESSION; NITRIC-OXIDE;
   VEGF-A; OBESITY; LEPTIN; FAT; INFLAMMATION; ACCUMULATION
AB Background: White adipose tissue (WAT) is a disperse organ acting as energy storage depot and endocrine/paracrine controlling factor in the management of energy availability and inflammation. WAT sites response under energy-related stress is not uniform. In the present study we have analyzed how different WAT sites respond to limited food restriction as a way to better understand the role of WAT in the pathogenesis of the metabolic syndrome.
   Methods: Overweight male rats had their food intake reduced a 40% compared with free-feeding controls. On day ten, the rats were killed; circulating glucose, insulin, leptin, adiponectin, triacylglycerols and other parameters were measured. The main WAT sites were dissected: mesenteric, retroperitoneal, epididymal and subcutaneous inguinal, which were weighed and frozen. Later all subcutaneous WAT was also dissected and weighed. Samples were used for DNA (cellularity) analysis and mRNA extraction and semiquantitarive RT-PCR analysis of specific cytokine gene expressions.
   Results: There was a good correlation between serum leptin and cumulative WAT leptin gene mRNA, but not for adiponectin. Food restriction reduced WAT size, but not its DNA content (except for epididymal WAT). Most cytokines were correlated to WAT site weight, but not to DNA. There was WAT site specialization in the differential expression (and probably secretion) of adipokines: subcutaneous WAT showed the highest concentration for leptin, CD68 and MCP-1, mesenteric WAT for TNF alpha (and both tissues for the interleukins 1 beta and 6); resistin was highly expressed in subcutaneous and retroperitoneal WAT.
   Conclusion: Food restriction induced different patterns for mesenteric and the other WAT sites, which may be directly related to both the response to intestine-derived energy availability, and an inflammatory-related response. However, retroperitoneal WAT, and to a lower extent, subcutaneous and epididymal, reacted decreasing the expression of inflammatory markers and the signaling of decreased energy availability in their stores. The varying cytokine expression patterns highlight the fact that WAT sites show different inflammatory and signaling responses to energy availability; they are too much different to simply extend to the whole-body WAT the findings of one or even a couple of sites.
C1 [del Mar Romero, Maria; Antonio Fernandez-Lopez, Jose; Esteve, Montserrat; Alemany, Maria] Univ Barcelona, Fac Biol, Dept Nutr & Food Sci, Barcelona, Spain.
C3 University of Barcelona
RP Alemany, M (corresponding author), Univ Barcelona, Fac Biol, Dept Nutr & Food Sci, Barcelona, Spain.
EM marromero@ub.edu; josfernandez@ub.edu; mesteve@ub.edu; malemany@ub.edu
RI Esteve, Montserrat/L-6272-2014; Romero, Maria del Mar/K-9004-2017;
   Fernandez-Lopez, Jose-Antonio/C-5467-2017; Alemany, Maria/H-5224-2011
OI Esteve, Montserrat/0000-0003-2128-7859; Romero, Maria del
   Mar/0000-0001-6274-5743; Fernandez-Lopez,
   Jose-Antonio/0000-0002-2856-7223; Alemany, Maria/0000-0002-9783-8293
FU Government of Spain [PI052179, SAF2006-05134]; CIBER Obesity and
   Nutrition of the Health Institute Carlos III of Spain; OED SL
   (Barcelona, Spain)
FX This study was supported by grants PI052179 of the "Fondo de
   Investigaciones Sanitarias" and SAF2006-05134 from the "Plan Nacional de
   Investigacion en Biomedicina", both from the Government of Spain, as
   well as by funds from the CIBER Obesity and Nutrition of the Health
   Institute Carlos III of Spain. Material and financial help from OED SL
   (Barcelona, Spain) is gratefully acknowledged.
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NR 50
TC 18
Z9 19
U1 0
U2 5
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1475-2840
J9 CARDIOVASC DIABETOL
JI Cardiovasc. Diabetol.
PD JUL 30
PY 2009
VL 8
AR 42
DI 10.1186/1475-2840-8-42
PG 13
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism
GA 493PS
UT WOS:000269750100001
PM 19642981
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Mahjoob, G
   Ahmadi, Y
   Rajani, HF
   Khanbabaei, N
   Abolhasani, S
AF Mahjoob, Golnoosh
   Ahmadi, Yasin
   Rajani, Huda Fatima
   Khanbabaei, Nafiseh
   Abolhasani, Sakhavat
TI Circulating microRNAs as predictive biomarkers of coronary artery
   diseases in type 2 diabetes patients
SO JOURNAL OF CLINICAL LABORATORY ANALYSIS
LA English
DT Review
DE biomarker; coronary artery diseases (CAD); diabetes mellitus type 2
   (T2DM); microRNAs
ID BLOOD MONONUCLEAR-CELLS; CARDIOVASCULAR-DISEASE; OXIDATIVE STRESS;
   EXPRESSION; SERUM; MELLITUS; MIRNAS; PLASMA; INFLAMMATION; HYPERTROPHY
AB Background Type 2 diabetes mellitus (T2DM) is an increasing metabolic disorder mostly resulting from unhealthy lifestyles. T2DM patients are prone to develop heart conditions such as coronary artery disease (CAD) which is a major cause of death in the world. Most clinical symptoms emerge at the advanced stages of CAD; therefore, establishing new biomarkers detectable in the early stages of the disease is crucial to enhance the efficiency of treatment. Recently, a significant body of evidence has shown alteration in miRNA levels associate with dysregulated gene expression occurring in T2DM and CAD, highlighting significance of circulating miRNAs in early detection of CAD arising from T2DM. Therefore, it seems crucial to establish a link between the miRNAs prognosing value and development of CAD in T2DM. Aim This study provides an overview on the alterations of the circulatory miRNAs in T2DM and various CADs and consider the potentials of miRNAs as biomarkers prognosing CADs in T2DM patients. Materials and Methods Literature search was conducted for miRNAs involved in development of T2DM and CAD using the following key words: "miRNAs", "Biomarker", "Diabetes Mellitus Type 2 (T2DM)", "coronary artery diseases (CAD)". Articles written in the English language. Result There has been shown a rise in miR-375, miR-9, miR-30a-5p, miR-150, miR-9, miR-29a, miR-30d, miR-34a, miR-124a, miR-146a, miR-27a, and miR-320a in T2DM; whereas, miR-126, miR-21, miR-103, miR-28-3p, miR-15a, miR-145, miR-375, miR-223 have been shown to decrease. In addition to T2DM, some miRNAs such as mirR-1, miR-122, miR-132, and miR-133 play a part in development of subclinical aortic atherosclerosis associated with metabolic syndrome. Some miRNAs increase in both T2DM and CAD such as miR-1, miR-132, miR-133, and miR-373-3-p. More interestingly, some of these miRNAs such as miR-92a elevate years before emerging CAD in T2DM. Conclusion dysregulation of miRNAs plays outstanding roles in development of T2DM and CAD. Also, elevation of some miRNAs such as miR-92a in T2DM patients can efficiently prognose development of CAD in these patients, so these miRNAs can be used as biomarkers in this regard.
C1 [Mahjoob, Golnoosh; Khanbabaei, Nafiseh; Abolhasani, Sakhavat] Sarab Fac Med Sci, Dept Clin Biochem, Sarab, Iran.
   [Mahjoob, Golnoosh; Khanbabaei, Nafiseh; Abolhasani, Sakhavat] Tarbiat Modares Univ, Dept Clin Biochem, Tehran, Iran.
   [Ahmadi, Yasin] Komar Univ Sci & Technol, Coll Sci, Dept Med Lab Sci, Sulaimani, Iraq.
   [Rajani, Huda Fatima] Univ Tehran Med Sci, Sch Adv Sci Med, Dept Med Biotechnol, Tehran, Iran.
C3 Tarbiat Modares University; Tehran University of Medical Sciences
RP Abolhasani, S (corresponding author), Sarab Fac Med Sci, Sarab Sch Med Sci & Hlth Serv, Imam Khomeini St, Sarab, East Azerbaijan, Iran.
EM bio.sakhi@gmail.com
RI Ahmadi, Yasin/ACP-8598-2022; ABOLHASANI, SAKHAVAT/AGO-2030-2022
OI Ahmadi, Yasin/0000-0001-6721-1775; ABOLHASANI,
   SAKHAVAT/0000-0001-9888-7508; Khanbabaei, Nafiseh/0000-0003-4960-7295;
   Rajani, Huda/0000-0001-9764-2154
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NR 104
TC 22
Z9 24
U1 2
U2 9
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 0887-8013
EI 1098-2825
J9 J CLIN LAB ANAL
JI J. Clin. Lab. Anal.
PD MAY
PY 2022
VL 36
IS 5
AR e24380
DI 10.1002/jcla.24380
EA MAR 2022
PG 8
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA 1F1SD
UT WOS:000774171900001
PM 35349731
OA Green Published
DA 2025-06-11
ER

PT J
AU Wang, XC
   Huang, YY
   Gao, JY
   Sun, H
   Jayachandran, M
   Qu, S
AF Wang, Xingchun
   Huang, Yueye
   Gao, Jingyang
   Sun, Hang
   Jayachandran, Muthukumaran
   Qu, Shen
TI Changes of serum retinol-binding protein 4 associated with improved
   insulin resistance after laparoscopic sleeve gastrectomy in Chinese
   obese patients
SO DIABETOLOGY & METABOLIC SYNDROME
LA English
DT Article
DE Retinol binding protein 4; Insulin resistance; Laparoscopic sleeve
   gastrectomy; Obesity
ID Y GASTRIC BYPASS; METABOLIC SYNDROME; RETINOL-BINDING-PROTEIN-4;
   GLUCOSE; RBP4; ADIPOSITY; DISEASE; RISK; FAT
AB Background Serum retinol-binding protein 4 (RBP4) plays a critical role in insulin resistance. The mechanism behind the impact of laparoscopic sleeve gastrectomy (LSG) on glucose metabolism is unclear. Hence, we aimed to investigate the triangle relationship between the RBP4, glucose metabolism, and LSG in patients of Chinese ethnicity. Methods The study enrolled eighty-two obese patients. Glucose-lipid metabolic index, uric acid (UA), superoxide dismutase (SOD), free triiodothyronine (FT3), free thyroxin (FT4) and thyrotropin (TSH) were measured. RBP4 levels were detected by enzyme-link immunosorbent assay. 30 obese patients underwent LSG were studied. All these markers were measured again at a time interval of 3 and 6 months after surgery. Results (1) Circulating RBP4 levels were positively associated with body mass index(BMI), blood glucose in 0 min (BG0), BG30, BG120, BG180, fasting inulin(FINS), fasting C peptide(FCP), homeostasis model of assessment for insulin resistance index (HOMA-IR), SOD, TSH and negatively associated with Matsuda index in obesity with a significant difference (P < 0.05). RBP4 levels in the patients with impaired fasting glucose (IFG), insulin resistance or hyperinsulinemia were significantly higher than the patients without IFG, insulin resistance or hyperinsulinemia (P = 0.035, P = 0.001, and P = 0.007). (2) LSG resulted in significantly decreased FBG, FINS, FCP and HOMA-IR at 3, 6 months after surgery (all P < 0.05). The RBP4 levels were significantly decreased after surgery (all P < 0.05) with no gender difference. (3) The change in RBP4 levels was significantly associated with the change in FINS, FCP, HOMA-IR, and HOMA-beta at 6 months and the change in TSH at 3 months after surgery in males (all P < 0.05). The change in RBP4 levels were significantly associated with the change in FINS, FCP, HOMA-IR, HOMA-beta, and TCH at 3 months after surgery in females (all P < 0.05). Conclusions Overall, our results interpret the significant correlations between RBP4, glucose-lipid metabolism, oxidative stress and thyroid function in obese patients. Further, the LSG brings a decline in RBP4 levels and that may contribute partly to the improved insulin resistance in obese Chinese patients.
C1 [Wang, Xingchun; Huang, Yueye; Gao, Jingyang; Sun, Hang; Jayachandran, Muthukumaran; Qu, Shen] Tongji Univ, Shanghai Peoples Hosp 10, Sch Med, Dept Endocrinol & Metab, Shanghai, Peoples R China.
   [Wang, Xingchun; Huang, Yueye; Gao, Jingyang; Sun, Hang; Jayachandran, Muthukumaran; Qu, Shen] 10th Hosp, Natl Metab Management Ctr, Shanghai 200072, Peoples R China.
C3 Tongji University
RP Qu, S (corresponding author), Tongji Univ, Shanghai Peoples Hosp 10, Sch Med, Dept Endocrinol & Metab, Shanghai, Peoples R China.
EM qushencn@hotmail.com
RI Jayachandran, Muthukumaran/AET-2681-2022; Wang, Xingchun/JCO-2698-2023;
   Qu, Shen/B-3405-2014
FU National Natural Science Foundation of China [NSFC 81900781]
FX This research was supported by the National Natural Science Foundation
   of China (NSFC 81900781).
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NR 39
TC 17
Z9 17
U1 0
U2 8
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1758-5996
J9 DIABETOL METAB SYNDR
JI Diabetol. Metab. Syndr.
PD JAN 14
PY 2020
VL 12
IS 1
AR 7
DI 10.1186/s13098-019-0511-1
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA KL8KR
UT WOS:000513667500001
PM 31956345
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Ding, SB
   Jiang, JJ
   Wang, Z
   Zhang, GF
   Yin, JL
   Wang, XY
   Wang, S
   Yu, ZL
AF Ding, Shibin
   Jiang, Jinjin
   Wang, Zhe
   Zhang, Guofu
   Yin, Jianli
   Wang, Xiaoya
   Wang, Sui
   Yu, Zengli
TI Resveratrol reduces the inflammatory response in adipose tissue and
   improves adipose insulin signaling in high-fat diet-fed mice
SO PEERJ
LA English
DT Article
DE Resveratrol; High-fat diet; Inflammation; Insulin resistance; Adipose
   tissue
ID ENDOPLASMIC-RETICULUM STRESS; NECROSIS-FACTOR-ALPHA; MACROPHAGE
   INFILTRATION; GLUCOSE-HOMEOSTASIS; HEPATIC STEATOSIS; RESISTANCE;
   OBESITY; EXPRESSION; CCR2; ACCUMULATION
AB Background: Obesity-induced glucose metabolism disorder is associated with chronic, low-grade, systemic inflammation and is considered a risk factor for diabetes and metabolic syndrome. Resveratrol (RES), a natural anti-inflammatory compound, is observed to improve glucose tolerance and insulin sensitivity in obese rodents and humans. This study aimed to test the effects of RES administration on insulin signaling and the inflammatory response in visceral white adipose tissue (WAT) caused by a high-fat diet (HFD) in mice.
   Methods: A total of 40 wild-type C57BL/6 male mice were divided into four groups (10 in each group): the standard chow diet (STD) group was fed a STD; the HFD group was fed a HFD; and the HFD-RES/L and HFD-RES/H groups were fed a HFD plus RES (200 and 400 mg/kg/day, respectively). The L and H in RES/L and RES/H stand for low and high, respectively. Glucose tolerance, insulin sensitivity, circulating inflammatory biomarkers and lipid profile were determined. Quantitative PCR and Western blot were used to determine the expression of CC-chemokine receptor 2 (CCR2), other inflammation markers, glucose transporter 4 (GLUT4), insulin receptor substrate 1 (IRS-1) and pAkt/Akt and to assess targets of interest involving glucose metabolism and inflammation in visceral WAT.
   Results: HFD increased the levels of total cholesterol, triglycerides, low-density lipoprotein cholesterol and proinflammatory cytokines in serum, decreased the high-density lipoprotein cholesterol level in serum, and induced insulin resistance and WAT inflammation in mice. However, RES treatment alleviated insulin resistance, increased the expressions of pAkt, GFUT4 and IRS-1 in WAT, and decreased serum proinflammatory cytokine levels, macrophage infiltration and CCR2 expression in WAT.
   Conclusion: Our results indicated that WAT CCR2 may play a vital role in macrophage infiltration and the inflammatory response during the development of insulin resistance in HFD-induced obesity. These data suggested that administration of RES offers protection against abnormal glucose metabolism and inflammatory adaptations in visceral WAT in mice with HFD-induced obesity.
C1 [Ding, Shibin; Wang, Zhe; Zhang, Guofu; Yin, Jianli; Wang, Xiaoya; Wang, Sui; Yu, Zengli] Xinxiang Med Univ, Sch Publ Hlth, Xinxiang, Henan, Peoples R China.
   [Ding, Shibin] Xinxiang Med Univ, Henan Collaborat Innovat Ctr Mol Diag & Lab Med, Xinxiang, Henan, Peoples R China.
   [Jiang, Jinjin] Capital Med Univ, Sch Publ Hlth, Beijing, Peoples R China.
C3 Xinxiang Medical University; Xinxiang Medical University; Capital
   Medical University
RP Ding, SB; Yu, ZL (corresponding author), Xinxiang Med Univ, Sch Publ Hlth, Xinxiang, Henan, Peoples R China.; Ding, SB (corresponding author), Xinxiang Med Univ, Henan Collaborat Innovat Ctr Mol Diag & Lab Med, Xinxiang, Henan, Peoples R China.
EM 141022@xxmu.edu.cn; zly@zzu.edu.cn
FU Key Scientific Research Project of Universities in Henan Province
   [16A330002]; Xinxiang Medical University [2014QN107]
FX This work was supported by the Key Scientific Research Project of
   Universities in Henan Province (No.16A330002) and the Scientific
   Research Fund of Xinxiang Medical University (No.2014QN107). The funders
   had no role in study design, data collection and analysis, decision to
   publish, or preparation of the manuscript.
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NR 43
TC 38
Z9 42
U1 1
U2 25
PU PEERJ INC
PI LONDON
PA 341-345 OLD ST, THIRD FLR, LONDON, EC1V 9LL, ENGLAND
SN 2167-8359
J9 PEERJ
JI PeerJ
PD JUN 29
PY 2018
VL 6
AR e5173
DI 10.7717/peerj.5173
PG 18
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA GL6AB
UT WOS:000437257100013
PM 29967759
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Hsieh, CJ
   Wang, PW
   Chen, TY
AF Hsieh, Ching-Jung
   Wang, Pei-Wen
   Chen, Tse-Ying
TI The relationship between regional abdominal fat distribution and both
   insulin resistance and subclinical chronic inflammation in non-diabetic
   adults
SO DIABETOLOGY & METABOLIC SYNDROME
LA English
DT Article
DE Subcutaneous fat; Intra-peritoneal fat; Retroperitoneal fat; Insulin
   resistance; High sensitive C-reactive protein; Adiponectin
ID C-REACTIVE PROTEIN; BODY-FAT; ADIPOSE-TISSUE; ASIAN INDIANS; METABOLIC
   SYNDROME; OXIDATIVE STRESS; VISCERAL FAT; ADIPONECTIN; SENSITIVITY;
   ADIPOKINES
AB Objective: Obesity is associated with a high risk of insulin resistance (IR) and its metabolic complications. It is still debated that distributions of adipose tissue relate to an excess risk of IR and chronic inflammation in different race. This study was designed to examine the relation between insulin sensitivity, chronic inflammation and central fat distribution in non-diabetic volunteers in Taiwanese.
   Methods: There were 328 volunteers without family history of diabetes mellitus and with normal oral glucose tolerance test enrolled. Total body fat and abdominal fat were measured. Abdominal fat was categorized into intraperitoneal (IP), retroperitoneal (RP) and subcutaneous (SC) fat. The IR index was estimated by homeostatic model assessment. Five inflammatory markers: adiponectin, leptin, tumor necrosing factor-alpha (TNF-alpha), resistin and high sensitive CRP (hs-CRP) were measured.
   Results: IR was related to IP fat (r = 0.23, p < 0.001), but not RP fat, SC fat or total body fat. After correcting for age and sex, IP fat was the only significant predictor of IR (r2 = 58%, p = 0.001). Leptin showed the strongest relationship with all fat compartments (IP fat: r = 0.44, p = 0.001; RP fat: r = 0.36, p = 0.005, SC fat: r = 0.54, p < 0.001; total body fat: r = 0.61, p < 0.001). The hs-CRP and adiponectin were closely related both to IP (r = 0.29, p = 0.004; r = -0.20, p = 0.046, respectively) and total body fat (r = 0.29, p = 0.004; r = -0.29, p = 0.005, respectively), but not RP, or SC fat. TNF-a and resistin were not correlated to any fat compartment. After correcting for age and sex, leptin variance was mostly explained by SC fat (41.3%), followed by IP fat (33.6%) and RP fat (25.3%). The hs-CRP and adiponectin variance were mostly explained by IP fat (40% and 49% respectively).
   Conclusions: IP fat is better predictors of IR and subclinical chronic inflammation in Taiwanese adults. A disproportionate accumulation of abdominal fat is associated with increased risk of cardiovascular diseases.
C1 [Hsieh, Ching-Jung; Wang, Pei-Wen; Chen, Tse-Ying] Chang Gung Univ, Coll Med, Dept Internal Med, Div Endocrinol & Metab,Kaohsiung Chang Gung Mem H, Niao Sung Hsiang 83305, Kaohsiung Hsien, Taiwan.
C3 Chang Gung University
RP Hsieh, CJ (corresponding author), Chang Gung Univ, Coll Med, Dept Internal Med, Div Endocrinol & Metab,Kaohsiung Chang Gung Mem H, 123 Ta Pei Rd, Niao Sung Hsiang 83305, Kaohsiung Hsien, Taiwan.
EM c2607c@ms56.hinet.net
RI Wang, Ying/I-5100-2019
FU Chang Gung Memorial Hospital - Kaohsiung Medical Center, Chang Gung
   University College of Medicine, Taiwan [CMRPG8065]
FX This work was supported by research grant (CMRPG8065) from Chang Gung
   Memorial Hospital - Kaohsiung Medical Center, Chang Gung University
   College of Medicine, Taiwan.
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NR 38
TC 43
Z9 49
U1 0
U2 13
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1758-5996
J9 DIABETOL METAB SYNDR
JI Diabetol. Metab. Syndr.
PD APR 1
PY 2014
VL 6
AR 49
DI 10.1186/1758-5996-6-49
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA AF3NW
UT WOS:000334620100001
PM 24684833
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Lim, SY
   Davidson, SM
   Paramanathan, AJ
   Smith, CCT
   Yellon, DM
   Hausenloy, DJ
AF Lim, Shiang Y.
   Davidson, Sean M.
   Paramanathan, Ajeev J.
   Smith, Christopher C. T.
   Yellon, Derek M.
   Hausenloy, Derek J.
TI The novel adipocytokine visfatin exerts direct cardioprotective effects
SO JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
LA English
DT Article
DE visfatin; ischaemia; reperfusion; cardioprotection
ID COLONY-ENHANCING FACTOR; PERMEABILITY TRANSITION PORE;
   ISCHEMIA-REPERFUSION INJURY; TYPE-2 DIABETES-MELLITUS; METABOLIC
   SYNDROME; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE;
   CARDIOVASCULAR-DISEASE; MYOCARDIAL-INFARCTION; WEIGHT-LOSS; EXPRESSION
AB Visfatin is an adipocytokine capable of mimicking the glucose-lowering effects of insulin and activating the pro-survival kinases phosphatidylinositol-3-OH kinase (PI3K)-protein kinase B (Akt) and mitogen-activated protein kinase kinase 1 and 2 (MEK1/2)-extracellular signal-regulated kinase 1 and 2 (Erk 1/2). Experimental studies have demonstrated that the activation of these kinases confers cardioprotection through the inhibition of the mitochondrial permeability transition pore (mPTP). Whether visfatin is capable of exerting direct cardioprotective effects through these mechanisms is unknown and is the subject of the current study. Anaesthetized C57BL/6 male mice were subjected to in situ 30 min. of regional myocardial ischaemia and 120 min. of reperfusion. The administration of an intravenous bolus of visfatin (5 x 10(-6) mu mol) at the time of myocardial reperfusion reduced the myocardial infarct size from 46.1 +/- 4.1% in control hearts to 27.3 +/- 4.0% (n >= 6/group, P < 0.05), an effect that was blocked by the PI3K inhibitor, wortmannin, and the MEK1/2 inhibitor, U0126 (48.8 +/- 5.5% and 45.9 +/- 8.4%, respectively, versus 27.3 +/- 4.0% with visfatin; n >= 6/group, P < 0.05). In murine ventricular cardiomyocytes subjected to 30 min. of hypoxia followed by 30 min. of reoxygenation, visfatin (100 ng/ml), administered at the time of reoxygenation, reduced the cell death from 65.2 +/- 4.6% in control to 49.2 +/- 3.7% (n > 200 cells/group, P < 0.05), an effect that was abrogated by wortmannin and U0126 (68.1 +/- 5.2% and 59.7 +/- 6.2%, respectively; n > 200 cells/group, P > 0.05). Finally, the treatment of murine ventricular cardiomyocytes with visfatin (100 ng/ml) delayed the opening of the mPTP induced by oxidative stress from 81.2 +/- 4 sec. in control to 120 +/- 7 sec. (n > 20 cells/group, P < 0.05) in a PI3K- and MEK1/2-dependent manner. We report that the adipocytokine, visfatin, is capable of reducing myocardial injury when administered at the time of myocardial reperfusion in both the in situ murine heart and the isolated murine cardiomyocytes. The mechanism appears to involve the PI3K and MEK1/2 pathways and the mPTP.
C1 [Yellon, Derek M.] UCL Hosp, Hatter Cardiovasc Inst, London WC1E 6HX, England.
   Sch Med, London WC1E 6HX, England.
C3 University College London Hospitals NHS Foundation Trust; University of
   London; University College London
RP Yellon, DM (corresponding author), UCL Hosp, Hatter Cardiovasc Inst, 67 Chenies Mews, London WC1E 6HX, England.
EM hatter-institute@ucl.ac.uk
RI Yellon, Derek/ABD-5110-2021; Lim, Shiang/E-9640-2011; Hausenloy,
   Derek/C-5348-2008; Davidson, Sean/F-5275-2010
OI Hausenloy, Derek/0000-0003-0729-4956; Yellon, Derek/0000-0001-7791-9320;
   Davidson, Sean/0000-0001-5182-4980; Lim, Shiang Yong/0000-0002-0442-3655
FU British Heart Foundation Funding Source: Medline; Wellcome Trust Funding
   Source: Medline
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NR 40
TC 121
Z9 138
U1 0
U2 12
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
EI 1582-4934
J9 J CELL MOL MED
JI J. Cell. Mol. Med.
PD AUG
PY 2008
VL 12
IS 4
BP 1395
EP 1403
DI 10.1111/j.1582-4934.2008.00332.x
PG 9
WC Cell Biology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Research & Experimental Medicine
GA 336IU
UT WOS:000258358300034
PM 18400051
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Lee, TL
   Hsuan, CF
   Hsu, CC
   Wei, CT
   Wang, CP
   Lu, YC
   Tang, WH
   Lu, NH
   Chung, FM
   Lee, YJ
   Tsai, IT
AF Lee, Thung-Lip
   Hsuan, Chin-Feng
   Hsu, Chia-Chang
   Wei, Ching-Ting
   Wang, Chao-Ping
   Lu, Yung-Chuan
   Tang, Wei-Hua
   Lu, Nan-Han
   Chung, Fu-Mei
   Lee, Yau-Jiunn
   Tsai, I-Ting
TI Associations of circulating total p-cresylsulfate and indoxyl
   sulfate concentrations with central obesity in patients with stable
   coronary artery disease: sex-specific insights
SO INTERNATIONAL JOURNAL OF OBESITY
LA English
DT Article
ID CHRONIC KIDNEY-DISEASE; BOUND UREMIC TOXINS; METABOLIC SYNDROME;
   ABDOMINAL OBESITY; OXIDATIVE STRESS; CRESYL SULFATE; INSULIN-RESISTANCE;
   POPULATION; PROTEIN; ADULTS
AB Background/aimsElevated systemic inflammation, common in obesity, increases cardiovascular disease risk. Obesity is linked to a pro-inflammatory gut microbiota that releases uremic toxins like p-cresylsulfate (PCS) and indoxyl sulfate (IS), which are implicated in coronary atherosclerosis, insulin resistance, and chronic kidney disease. This study examines the relationship between total PCS and IS levels and central obesity in patients with stable coronary artery disease (CAD). MethodsA cross-sectional study was conducted on 373 consecutive patients with stable CAD from a single center. Serum levels of total PCS and IS were measured using an Ultra Performance LC System. Central obesity was evaluated using a body shape index (ABSI) and conicity index (CI). Six obesity-related proteins were also analyzed. Structural equation modeling (SEM) assessed direct and indirect effects of total PCS, IS, and the six obesity-related proteins on central obesity. ResultsSignificant positive correlations were found between total PCS and IS with waist-to-hip ratio (WHR) (r = 0.174, p = 0.005 for total PCS; r = 0.144, p = 0.021 for IS), CI (r = 0.273, p < 0.0001 for total PCS; r = 0.260, p < 0.0001 for IS), and ABSI (r = 0.297, p < 0.0001 for total PCS; r = 0.285, p < 0.0001 for IS) in male patients, but not in female patients. Multivariate analysis showed higher odds ratios (ORs) for elevated CI (OR = 3.18, 95% CI: 1.54-6.75, p = 0.002) and ABSI (OR = 3.28, 95% CI: 1.54-7.24, p = 0.002) in patients with high PCS levels, and elevated CI (OR = 2.30, 95% CI: 1.15-4.66, p = 0.018) and ABSI (OR = 2.22, 95% CI: 1.07-4.72, p = 0.033) in those with high IS levels, compared to those with low toxin levels. SEM analysis indicated that total PCS and IS directly impacted central obesity indices and indirectly influenced central adiposity measures like WHR through high sensitivity C-reactive protein (hs-CRP) (beta = 0.252, p < 0.001). ConclusionsCirculating total PCS and IS contribute to central obesity in male patients with stable CAD, partially mediated by hs-CRP.
C1 [Lee, Thung-Lip; Hsuan, Chin-Feng; Wang, Chao-Ping; Chung, Fu-Mei] I Shou Univ, E Da Hosp, Dept Internal Med, Div Cardiol, Kaohsiung 82445, Taiwan.
   [Lee, Thung-Lip; Wang, Chao-Ping] I Shou Univ, Coll Med, Sch Med Int Students, Kaohsiung 82445, Taiwan.
   [Hsuan, Chin-Feng; Lu, Nan-Han; Tsai, I-Ting] I Shou Univ, Coll Med, Sch Med, Kaohsiung 82445, Taiwan.
   [Hsuan, Chin-Feng] I Shou Univ, E Da Dachang Hosp, Dept Internal Med, Div Cardiol, Kaohsiung 807066, Taiwan.
   [Hsu, Chia-Chang] I Shou Univ, E Da Hosp, Dept Internal Med, Div Gastroenterol & Hepatol, Kaohsiung 82445, Taiwan.
   [Hsu, Chia-Chang] I Shou Univ, E Da Dachang Hosp, Hlth Examinat Ctr, Kaohsiung 807066, Taiwan.
   [Hsu, Chia-Chang; Wei, Ching-Ting] I Shou Univ, Coll Med, Sch Chinese Med Post Baccalaureate, Kaohsiung 82445, Taiwan.
   [Wei, Ching-Ting] I Shou Univ, E Da Hosp, Dept Surg, Div Gen Surg, Kaohsiung 82445, Taiwan.
   [Lu, Yung-Chuan] E Da Hosp, Dept Internal Med, Div Endocrinol & Metab, Kaohsiung 82445, Taiwan.
   [Tang, Wei-Hua] Taipei Vet Gen Hosp, Dept Internal Med, Div Cardiol, Yuli Branch, Hualien 98142, Taiwan.
   [Tang, Wei-Hua] Natl Yang Ming Chiao Tung Univ, Fac Med, Sch Med, Taipei 112304, Taiwan.
   [Lu, Nan-Han] I Shou Univ, E Da Canc Hosp, Dept Radiol, Kaohsiung 82445, Taiwan.
   [Lee, Yau-Jiunn] Lees Endocrinol Clin, Pingtung 90000, Taiwan.
   [Tsai, I-Ting] I Shou Univ, E Da Hosp, Dept Emergency, Kaohsiung 82445, Taiwan.
C3 I Shou University; E-Da Hospital; I Shou University; I Shou University;
   I Shou University; E-Da Hospital; E-Da Hospital; I Shou University; I
   Shou University; E-Da Hospital; I Shou University; I Shou University;
   E-Da Hospital; E-Da Hospital; Taipei Veterans General Hospital; National
   Yang Ming Chiao Tung University; I Shou University; E-Da Hospital; E-Da
   Hospital; I Shou University
RP Tsai, IT (corresponding author), I Shou Univ, Coll Med, Sch Med, Kaohsiung 82445, Taiwan.; Tsai, IT (corresponding author), I Shou Univ, E Da Hosp, Dept Emergency, Kaohsiung 82445, Taiwan.
EM tsai.iting@gmail.com
RI Wei, Ching-Ting/GSI-4081-2022
FU E-Da Hospital of the Republic of China, Taiwan [EDAHP103052,
   EDAHP106058, EDCHP106009, EDAHI112001]
FX This work was supported by grants from E-Da Hospital of the Republic of
   China, Taiwan (contract no. EDAHP103052, EDAHP106058, EDCHP106009, and
   EDAHI112001)
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NR 61
TC 2
Z9 2
U1 0
U2 2
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0307-0565
EI 1476-5497
J9 INT J OBESITY
JI Int. J. Obes.
PD DEC
PY 2024
VL 48
IS 12
BP 1775
EP 1784
DI 10.1038/s41366-024-01624-1
EA SEP 2024
PG 10
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA N0K1Z
UT WOS:001307605500001
PM 39237758
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Nalbantoglu, IC
   Sevgi, S
   Kerimoglu, G
   Kadioglu Duman, M
   Kalyoncu, NI
AF Nalbantoglu, Irem Cavusoglu
   Sevgi, Serhat
   Kerimoglu, Gokcen
   Kadioglu Duman, Mine
   Kalyoncu, Nuri Ihsan
TI Ursodeoxycholic acid ameliorates erectile dysfunction and corporal
   fibrosis in diabetic rats by inhibiting the TGF-β1/Smad2 pathway
SO INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH
LA English
DT Article
ID GROWTH-FACTOR-BETA; TGF-BETA; PENILE FIBROSIS; CAVERNOUS NERVE;
   ELECTRICAL-STIMULATION; METABOLIC SYNDROME; SIGNALING PATHWAY; OXIDATIVE
   STRESS; MESANGIAL CELLS; RENAL FIBROSIS
AB Corporal tissue fibrosis is critical in diabetes-associated erectile dysfunction. Transforming growth factor-beta 1/Small mothers against decapentaplegic-2 (TGF-beta 1/Smad2) contributes to the induction of fibrosis in corporal tissue. Smad7 is accepted as a general negative regulator of Smad signaling, although its role in corporal fibrosis is unknown. Ursodeoxycholic acid (UDCA) is a hydrophilic bile acid used for biliary and liver related disorders and has antifibrotic effects in the liver. This study investigated the effects of UDCA on diabetic erectile dysfunction. Forty-eight male Spraque Dawley rats were divided into six groups: nondiabetic (n=6), nondiabetic+20mg/kg UDCA (n=6), nondiabetic+80mg/kg UDCA (n=6), diabetic (n=10), diabetic+20mg/kg UDCA (n=10), diabetic+80mg/kg UDCA (n=10). Diabetes was induced by intraperitoneal injection of 60mg/kg Streptozocin. UDCA (20 and 80mg/kg/day) or saline was subsequently administered via oral gavage for 56 days. Erectile function was evaluated as measurement of maximum intracavernosal pressure (m-ICP)/mean arterial pressure (MAP) and total ICP/MAP. Corporal tissues were evaluated by Western blotting and Masson's trichrome staining. Electrical stimulation-induced m-ICP/MAP responses were higher in UDCA-treated diabetic rats compared to untreated diabetic rats, respectively (20mg/kg; 4V: 0.77 +/- 0.11 vs 0.45 +/- 0.09, p=0.0001 and 80mg/kg; 4V: 0.78 +/- 0.11 vs 0.45 +/- 0.09, p=0.0001) UDCA prevented the increase in phospho-Smad2 and fibronectin protein expressions in diabetic corporal tissue both at 20mg/kg (p=0.0002, p=0.002 respectively) and 80mg/kg doses (p<0.0001 for both). Smad7 protein expressions were significantly increased in the UDCA-treated diabetic groups compared to the untreated diabetic group (20mg/kg: p=0.0079; 80mg/kg: p=0.004). Furthermore, UDCA significantly prevented diabetes-induced increase in collagen (20mg/kg: p=0.0172; 80mg/kg: p=0.0003) and smooth muscle loss (20mg/kg: p=0.044; 80mg/kg: p=0.039). In conclusion, UDCA has a potential protective effect on erectile function in diabetic rats by altering fibrotic pathways via inhibition of TGF-beta 1/Smad2 and activation of Smad7.
C1 [Nalbantoglu, Irem Cavusoglu] Karadeniz Tech Univ, Grad Sch Hlth Sci, Dept Pharmacol, Trabzon, Turkiye.
   [Sevgi, Serhat] Karadeniz Tech Univ, Dept Pharmacol, Fac Pharm, Trabzon, Turkiye.
   [Kerimoglu, Gokcen] Karadeniz Tech Univ, Dept Histol & Embryol, Fac Med, Trabzon, Turkiye.
   [Kadioglu Duman, Mine; Kalyoncu, Nuri Ihsan] Karadeniz Tech Univ, Dept Pharmacol, Fac Med, Trabzon, Turkiye.
C3 Karadeniz Technical University; Karadeniz Technical University;
   Karadeniz Technical University; Karadeniz Technical University
RP Nalbantoglu, IC (corresponding author), Karadeniz Tech Univ, Grad Sch Hlth Sci, Dept Pharmacol, Trabzon, Turkiye.
EM iremcavusoglu@ktu.edu.tr
RI Kerimoğlu, Gökçen/AAS-5020-2020; KALYONCU, NURI/AAL-9829-2021; sevgi,
   serhat/AAK-6273-2021; Kadioglu, Mine/B-1427-2012
OI Cavusoglu, Irem/0000-0001-5487-7527; Kerimoglu,
   Gokcen/0000-0002-4349-7796
FU Scientific Research Project Coordination Unit of Karadeniz Technical
   University [TDK-2020-8748]
FX This study was supported by the Scientific Research Project Coordination
   Unit of Karadeniz Technical University (Grant Number: TDK-2020-8748) and
   presented as a part of doctoral thesis.
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NR 83
TC 1
Z9 1
U1 5
U2 8
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0955-9930
EI 1476-5489
J9 INT J IMPOT RES
JI Int. J. Impot. Res.
PD DEC
PY 2024
VL 36
IS 8
BP 886
EP 895
DI 10.1038/s41443-024-00868-9
EA MAR 2024
PG 10
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA O4Z7F
UT WOS:001181141900001
PM 38454160
DA 2025-06-11
ER

PT J
AU Ahsan, F
   Oliveri, F
   Goud, HK
   Mehkari, Z
   Mohammed, L
   Javed, M
   Althwanay, A
   Rutkofsky, IH
AF Ahsan, Farah
   Oliveri, Federico
   Goud, Harshit K.
   Mehkari, Zainab
   Mohammed, Lubna
   Javed, Moiz
   Althwanay, Aldanah
   Rutkofsky, Ian H.
TI Pleiotropic Effects of Statins in the Light of Non-Alcoholic Fatty Liver
   Disease and Non-Alcoholic Steatohepatitis
SO CUREUS JOURNAL OF MEDICAL SCIENCE
LA English
DT Review
DE nafld; nash; statins; steatosis; fatty acid oxidation; cytokines; nash
   and statins
ID ROSUVASTATIN; RESOLUTION; MORTALITY; NAFLD
AB Statins, the lipid-lowering drugs, and non-alcoholic fatty liver disease (NAFLD)/non-alcoholic steatohepatitis (NASH), a lipid-related pathology, share a complex relationship, one known to be hepatotoxic and other being hepatic injury. NASH is an unresolved mystery in terms of treatment. Could statins prove to be a promising solution due to their pleiotropic properties in addition to the cholesterol-lowering effect? This study aims to find statin effectiveness in NAFLD/NASH treatment and prevention of associated adverse outcomes. An extensive data search was done to identify the studies assessing statin effect on NAFLD/NASH and then analyzed to establish the relationship. Several studies demonstrated a reduction in NAFLD/NASH-associated inflammation and fibrosis with statin treatment. These anti-inflammatory and anti-fibrotic effects were through their pleiotropic properties, which were in addition to their cholesterol-lowering effect. In various animal studies, statins were found to improve hepatic lipotoxicity, oxidative stress, inflammatory responses, and fibrosis associated with NASH through multiple pathways. Statins exert these protective effects by recovering the gene expression level of peroxisomal proliferator-activated receptor alpha (PPAR alpha) and therefore restore the mitochondrial and peroxisomal fatty acid oxidation (FAO). Statin treatment also increased the levels of paraoxonase 1 (PON1), an antioxidant and antiatherogenic enzyme that is reduced in NAFLD as well as encounter the hepatic lipotoxicity by resolving cholesterol crystals and Kupffer cells (KCs) with crown-like structures (CLSs). They exhibited antitumor properties by inhibiting proinflammatory cytokines and vascular proliferative factors. Moreover, they restored a healthy liver sinusoidal endothelial cell (LSEC) and hepatic stellate cells (HSC) along with inhibiting the activation of HSC via modulating inducible nitric oxide synthase (iNOS) and expressions of endothelial nitric oxide synthase (eNOS). Besides, they were protective against cardiovascular disease (CVD)-related morbidity and mortality, hepatocellular carcinoma (HCC), and metabolic syndrome (MS) associated with NAFLD/NASH. NASH and its precursor, NAFLD, could be treated and prevented with statins owing to their pleiotropic properties. This study helps to prove this by looking back at different literature and has successfully enlightened the point. Once proved through large clinical trials on humans, it could revolutionize the NASH therapy.
C1 [Ahsan, Farah; Goud, Harshit K.; Mehkari, Zainab; Mohammed, Lubna; Javed, Moiz; Althwanay, Aldanah] Calif Inst Behav Neurosci & Psychol, Internal Med, Fairfield, CT 94534 USA.
   [Oliveri, Federico] Calif Inst Behav Neurosci & Psychol, Cardiol, Fairfield, CT USA.
   [Rutkofsky, Ian H.] Calif Inst Behav Neurosci & Psychol, Neurosci, Psychiat, Fairfield, CT USA.
RP Ahsan, F (corresponding author), Calif Inst Behav Neurosci & Psychol, Internal Med, Fairfield, CT 94534 USA.
EM farahahsanes@gmail.com
RI Mohammed, Lubna/AAK-4226-2021
OI Mohammed, Lubna/0000-0002-1803-6867; Oliveri,
   Federico/0000-0001-5946-0827
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NR 32
TC 31
Z9 32
U1 0
U2 12
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
EI 2168-8184
J9 CUREUS J MED SCIENCE
JI Cureus J Med Sci
PD SEP 14
PY 2020
VL 12
IS 9
AR e10446
DI 10.7759/cureus.10446
PG 17
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA NN8EW
UT WOS:000569020800012
PM 33072455
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Martinez-Navarro, I
   Vilchis-Gil, J
   Cossio-Torres, PE
   Hernandez-Mendoza, H
   Kluender-Kluender, M
   Layseca-Espinosa, E
   Galicia-Cruz, OG
   Rios-Lugo, MJ
AF Martinez-Navarro, Israel
   Vilchis-Gil, Jenny
   Cossio-Torres, Patricia Elizabeth
   Hernandez-Mendoza, Hector
   Kluender-Kluender, Miguel
   Layseca-Espinosa, Esther
   Galicia-Cruz, Othir Gidalti
   Rios-Lugo, Maria Judith
TI Relationship of Serum Zinc Levels with Cardiometabolic Traits in
   Overweight and Obese Schoolchildren from Mexico City
SO BIOLOGICAL TRACE ELEMENT RESEARCH
LA English
DT Article
DE Serum zinc level; Body mass index z score; Overweight/obesity;
   Cardiometabolic traits; Schoolchildren
ID CHILDREN AGED 1; NUTRITIONAL-STATUS; CHILDHOOD OVERWEIGHT; METABOLIC
   SYNDROME; OXIDATIVE STRESS; WAIST CIRCUMFERENCE; INSULIN-RESISTANCE;
   BODY-COMPOSITION; TRACE-ELEMENTS; ASSOCIATION
AB Zinc (Zn) participates as a cofactor for many enzymes in the cellular metabolism, and its serum levels have been associated with different metabolic diseases, especially obesity (OB). Nevertheless, its associations are not clear in the children population. The objective of this study is to evaluate the association between serum Zn levels (SZn) with overweight/obesity status (OW/OB), as well as its cardiometabolic traits in a population of children in Mexico City. Anthropometrical data (body mass index z score (BMIz)), demographic variables (age and sex), and cardiometabolic traits (total cholesterol (TC), high-density lipoprotein cholesterol (HDLc), low-density lipoprotein cholesterol (LDLc), triglycerides (TG), fasting plasma glucose (FPG), and insulin) were analyzed in this cross-sectional study. SZn were measured by inductively coupled plasma mass spectrometry (ICP-MS). The population included 210 children from Mexico City (girls (n = 105) and boys (n = 105)) between ages 6 and 10 years. Normal-weight (NW) schoolchildren had higher SZn concentrations (66 mu g/dL; IQR: 48 to 91) compared to OW or OB schoolchildren (61 mu g/dL; IQR: 45 to 76). The data showed a significant negative association between SZn and BMIz without sex exclusion (r = - 0.181 and p = 0.009). The boy's population did not show an association between the SZn and BMIz compared to the girl's population which showed a significant negative association (r = - 0.277 and p = 0.004). In addition, other associations were found between SZn and TC (boys (r = 0.214 and p = 0.025), LDLc (boys (r = 0.213 and p = 0.029), and TG (girls (r = - 0.260 and p = 0.007)). Moreover, 38.6% of the total children in our population study had Zn deficiency (ZnD). NW schoolchildren had higher SZn concentrations compared to OW or OB schoolchildren. A diet low in Zn can be a factor to evaluate in the development of childhood OB in Mexico. However, further studies need to be performed on the children Mexican population to replicate and confirm our findings.
C1 [Martinez-Navarro, Israel] Univ Autonoma San Luis Potosi, Fac Med, Posgrad Ciencias Bas, Ave Venustiano Carranza 2405, Venustiano Carranza 78210, San Luis Potosi, Mexico.
   [Vilchis-Gil, Jenny] Hosp Infantil Mex Feder Gomez, Unidad Invest Epidemiol Endocrinol & Nutr, Secretaria Salud, Mexico City 06720, Mexico.
   [Cossio-Torres, Patricia Elizabeth] Univ Autonoma San Luis Potosi, Fac Med, Dept Salud Publ & Ciencias Med, Ave Venustiano Carranza 2405, Venustiano Carranza 78210, San Luis Potosi, Mexico.
   [Hernandez-Mendoza, Hector] Univ Autonoma San Luis Potosi, Inst Invest Zonas Desert, Altair 200, San Luis Potosi 78377, Mexico.
   [Hernandez-Mendoza, Hector] Hosp Gen Soledad Graciano Sanchez, Secretaria Salud, Soledad Graciano Sanchez,Valentin Amador 1112, San Luis Potosi 78435, Mexico.
   [Kluender-Kluender, Miguel] Hosp Infantil Mex Feder Gomez, Direcc Invest, Secretaria Salud, Mexico City 06720, Mexico.
   [Layseca-Espinosa, Esther; Rios-Lugo, Maria Judith] Univ Autonoma San Luis Potosi, Ctr Invest Ciencias Salud & Biomed, Secc Med Mol & Traslac, Avda Sierra Leona 550, San Luis Potosi 78210, Mexico.
   [Galicia-Cruz, Othir Gidalti] Univ Autonoma San Luis Potosi, Fac Med, Dept Farmacol, Ave Venustiano Carranza 2405, Venustiano Carranza 78210, San Luis Potosi, Mexico.
   [Rios-Lugo, Maria Judith] Univ Autonoma San Luis Potosi, Fac Enfermeria & Nutr, Un Posgrad, Avda Nino Artillero 130, San Luis Potosi 78210, Mexico.
C3 Universidad Autonoma de San Luis Potosi; Hospital Infantil de Mexico
   Federico Gomez; Universidad Autonoma de San Luis Potosi; Universidad
   Autonoma de San Luis Potosi; Hospital Infantil de Mexico Federico Gomez;
   Universidad Autonoma de San Luis Potosi; Universidad Autonoma de San
   Luis Potosi; Universidad Autonoma de San Luis Potosi
RP Hernandez-Mendoza, H (corresponding author), Univ Autonoma San Luis Potosi, Inst Invest Zonas Desert, Altair 200, San Luis Potosi 78377, Mexico.; Hernandez-Mendoza, H (corresponding author), Hosp Gen Soledad Graciano Sanchez, Secretaria Salud, Soledad Graciano Sanchez,Valentin Amador 1112, San Luis Potosi 78435, Mexico.; Rios-Lugo, MJ (corresponding author), Univ Autonoma San Luis Potosi, Ctr Invest Ciencias Salud & Biomed, Secc Med Mol & Traslac, Avda Sierra Leona 550, San Luis Potosi 78210, Mexico.; Rios-Lugo, MJ (corresponding author), Univ Autonoma San Luis Potosi, Fac Enfermeria & Nutr, Un Posgrad, Avda Nino Artillero 130, San Luis Potosi 78210, Mexico.
EM hector.mendoza@uaslp.mx; judith.rios@uaslp.mx
RI Klunder-Klunder, Miguel/F-6539-2014; Lugo, María Judith/GWU-9400-2022;
   Vilchis-Gil, Jenny/AAD-6485-2021; Cossio-Torres, Patricia/AAA-3632-2021
OI Cossio-Torres, Patricia Elizabeth/0000-0002-7626-8949; Vilchis-Gil,
   Jenny/0000-0002-5473-6772; Galicia Cruz, Othir
   Gidalti/0009-0007-5497-2576
FU Consejo Nacional de Ciencia y Tecnologia (CONACYT) [315880-CONACYT];
   Hospital Infantil de Mexico Federico Gomez (Fondos Federales)
   [HIM/2013/003]; CONACYT [2020-000026-02NACF-17180]
FX The present work was supported by Consejo Nacional de Ciencia y
   Tecnologia (CONACYT) in the following projects: Labora-torio Nacional de
   Ciencia, Tecnologia y Gestion Integrada del Agua (Project:
   315880-CONACYT) and by Hospital Infantil de Mexico Federico Gomez
   (Fondos Federales HIM/2013/003). We thank CONACYT for the doctoral
   scholarship awarded (2020-000026-02NACF-17180).
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NR 102
TC 4
Z9 5
U1 1
U2 6
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0163-4984
EI 1559-0720
J9 BIOL TRACE ELEM RES
JI Biol. Trace Elem. Res.
PD SEP
PY 2023
VL 201
IS 9
BP 4307
EP 4319
DI 10.1007/s12011-022-03533-8
EA DEC 2022
PG 13
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA M6DF9
UT WOS:000904030900001
PM 36572827
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Ronningen, R
   Wammer, ACP
   Grabner, NH
   Valderhaug, TG
AF Ronningen, Reidun
   Wammer, Anne Cathrine Parelius
   Grabner, Nina Holte
   Valderhaug, Tone Gretland
TI Associations between Lifetime Adversity and Obesity Treatment in
   Patients with Morbid Obesity
SO OBESITY FACTS
LA English
DT Article
DE Bariatric surgery; Eating behavior; Obesity; Psychological aspects;
   Stress overnutrition
ID BARIATRIC SURGERY; PHYSICAL-ACTIVITY; METABOLIC SYNDROME; WEIGHT STIGMA;
   HEALTH; ADULTS; CARE; BEHAVIORS; MORTALITY; DEATH
AB Background: Bariatric surgery is associated with greater and more sustainable weight loss compared with lifestyle intervention programs. On the other hand, bariatric surgery may also be associated with physical and psychosocial complications. The influence of psychological evaluation on treatment choice, however, is not known. We aimed to examine variables associated with treatment choice and, specifically, if self-reported lifetime adversity influenced obesity treatment, i.e. bariatric surgery, high-intensive lifestyle treatment or low-intensive lifestyle treatment in primary care. Methods: We consecutively included 924 patients from the registry study of patients with morbid obesity at Akershus University Hospital, Lorenskog, Norway. Treatment selection was made through a shared decision-making process. Self-reported lifetime adversity was registered by trained personnel. Logistic regression models were used to assess the associations between obesity treatment and possible predictors. Results: Patients who chose bariatric surgery were more likely to have type 2 diabetes (DM2) compared with patients who chose lifestyle treatment (bariatric surgery: 35%, high-intensive lifestyle treatment: 26%, and low-intensive lifestyle treatment: 26%; p = 0.035). Patients who chose bariatric surgery were less likely than patients who chose lifestyle intervention to report lifetime adversity (bariatric surgery: 39%, high-intensive lifestyle treatment: 47%, and low-intensive lifestyle treatment: 51%; p = 0.004). After multivariable adjustments, increasing BMI, having DM2, and joint pain were associated with choosing bariatric surgery over non-surgical obesity treatment (odds ratio [95% CI]: BMI 1.03 [1.01-1.06], DM2 1.47 [1.09-1.99], and joint pain 1.46 [1.08-1.96]). Self-reported lifetime adversity was furthermore associated with lower odds of choosing bariatric surgery in patients with morbid obesity (0.67 [0.51-0.89]). Conclusion: This study shows that increasing BMI, DM2, and joint pain were all associated with treatment choice for obesity. In addition, self-reported lifetime adversity was associated with the patients' treatment choice for morbid obesity. Consequently, we suggest that decisions concerning obesity treatment should include dialogue-based assessments of the patients' lifetime adversity. (C) 2019 The Author(s) Published by S. Karger AG, Basel
C1 [Ronningen, Reidun; Wammer, Anne Cathrine Parelius; Valderhaug, Tone Gretland] Akershus Univ Hosp HF, Dept Endocrinol, Lorenskog, Norway.
   [Grabner, Nina Holte] Akershus Univ Hosp, Dept Psychiat, Unit Consultat Liason Psychiat, Lorenskog, Norway.
C3 University of Oslo
RP Valderhaug, TG (corresponding author), Akershus Univ Hosp, Dept Endocrinol, Div Med, Sykehusveien 25, NO-1478 Lorenskog, Norway.
EM t.g.valderhaug@medisin.uio.no
RI Valderhaug, Tone/Y-2993-2019
OI Valderhaug, Tone Gretland/0000-0002-9953-7865
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NR 46
TC 9
Z9 9
U1 0
U2 7
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1662-4025
EI 1662-4033
J9 OBESITY FACTS
JI Obes. Facts
PY 2019
VL 12
IS 1
BP 1
EP 13
DI 10.1159/000494333
PG 13
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA HP9UA
UT WOS:000462037300001
PM 30654360
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Guo, YJ
   Cao, LM
   Zhou, Y
   Xiao, LL
   Zhang, XM
   Yuan, J
   Chen, WH
AF Guo, Yanjun
   Cao, Limin
   Zhou, Yun
   Xiao, Lili
   Zhang, Xiaomin
   Yuan, Jing
   Chen, Weihong
TI Cardiometabolic traits mediated the relationship from urinary polycyclic
   aromatic hydrocarbons metabolites to heart rate variability reduction: A
   community-based study
SO ENVIRONMENTAL POLLUTION
LA English
DT Article
DE Urinary polycyclic aromatic hydrocarbons metabolites (OH-PAHs);
   Metabolic traits; Heart rate variability (HRV); Mediate effect
ID AMBIENT AIR-POLLUTION; DOSE-RESPONSE RELATIONSHIP;
   CARDIOVASCULAR-DISEASE; CHILDHOOD OBESITY; OXIDATIVE STRESS; EXPOSURE;
   DAMAGE; RISK; MORTALITY; DNA
AB Polycyclic Aromatic Hydrocarbons (PAHs) exposure was related with metabolic syndrome (MetS) and heart rate variability (HRV) reduction, and HRV was also affected by cardiometabolic traits. However, the role of cardiometabolic traits in the associations from PAHs exposures to HRV was largely unknown. We conducted this study to investigate whether the relationship between PAHs exposure and HRV reduction was mediated by cardiometabolic traits. Levels of urinary polycyclic aromatic hydrocarbons metabolites (OH-PAHs), 10min-HRV, and metabolic traits were accurately measured for 2476 participants from Wuhan-Zhuhai (WHZH) cohort. Single mediator and multiple mediator models were used to evaluate the mediation effects of cadiometabolic traits. The concentrations of Sigma OH-PAHs ranged from 4.20 to 8.63 mg/mmot Cr. When compared with the lowest tertile, Sigma OH-PAHs in the highest tertile were significantly related with 20% (95% confidence interval [95%CI]:1%, 40%), 35% (95%CI: 14%, 56%), 22% (95% CI: 1%, 44%), and 38% (95%CI: 9%, 68%) decreases in very low frequency (VLF), low frequency (LF), high frequency (HF), and total power (TP) for participants with MetS, respectively. No statistically significant associations between Sigma OH-PAHs and HRV indices were observed for participants without MetS. Similar results were found when we investigated the relationships between OH-PAHs and HRV indices by three groups of OH-PAHs (including total hydroxynaphthalene [Sigma OHNa], total hydroxy fluorene [Sigma OHFlu], and total hydroxyphenanthrene [Sigma OHPh] metabolites). Further, mediation analysis suggested that cardiometabolic traits, including fasting glucose (GLU), high density lipoprotein (HDL), and blood pressure partially mediated the relationship from Sigma OH-PAHs to HRV reduction. GLU was the strongest mediator, with mediation percentages of 15.70% for VLF, 14.70% for LF, 43.03% for HF, and 5.61% for TP. Our study found that the relationships between OH-PAHs and HRV reduction differed among participants with and without MetS, and these relationships were found to be partially mediated by cardiometabolic traits, especially fasting glucose. Further studies are encouraged to validate our findings and investigate potential mechanisms. (C) 2018 Elsevier Ltd. All rights reserved.
C1 [Guo, Yanjun; Cao, Limin; Zhou, Yun; Xiao, Lili; Zhang, Xiaomin; Yuan, Jing; Chen, Weihong] Huazhong Univ Sci & Technol, Dept Occupat & Environm Hlth, Sch Publ Hlth, Tongji Med Coll, Wuhan 430030, Hubei, Peoples R China.
   [Guo, Yanjun; Cao, Limin; Zhou, Yun; Xiao, Lili; Zhang, Xiaomin; Yuan, Jing; Chen, Weihong] Huazhong Univ Sci & Technol, Key Lab Environm & Hlth, Minist Educ, Sch Publ Hlth,Tongji Med Coll, Wuhan, Hubei, Peoples R China.
   [Guo, Yanjun; Cao, Limin; Zhou, Yun; Xiao, Lili; Zhang, Xiaomin; Yuan, Jing; Chen, Weihong] Huazhong Univ Sci & Technol, Minist Environm Protect, Sch Publ Hlth, Tongji Med Coll, Wuhan, Hubei, Peoples R China.
   [Guo, Yanjun; Cao, Limin; Zhou, Yun; Xiao, Lili; Zhang, Xiaomin; Yuan, Jing; Chen, Weihong] Huazhong Univ Sci & Technol, State Key Lab Environm Hlth Incubating, Sch Publ Hlth, Tongji Med Coll, Wuhan, Hubei, Peoples R China.
C3 Huazhong University of Science & Technology; Huazhong University of
   Science & Technology; Ministry of Education - China; Huazhong University
   of Science & Technology; Huazhong University of Science & Technology
RP Chen, WH (corresponding author), Huazhong Univ Sci & Technol, Dept Occupat & Environm Hlth, Sch Publ Hlth, Tongji Med Coll, Wuhan 430030, Hubei, Peoples R China.
EM wchen@mails.tjmu.edu.cn
RI zhang, xiaomin/IQX-1078-2023; Chen, Weihong/D-2177-2011
FU Key Program of the National Natural Science Foundation of China
   [91543207]; China Postdoctoral Science Foundation [2016M600598]
FX This study was supported by the Key Program of the National Natural
   Science Foundation of China (91543207) and China Postdoctoral Science
   Foundation Funded Project (2016M600598). The funder had no involvement
   in the study design, study management, data collection, data analysis,
   data interpretation, or writing of the manuscript.
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NR 49
TC 12
Z9 12
U1 0
U2 35
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0269-7491
EI 1873-6424
J9 ENVIRON POLLUT
JI Environ. Pollut.
PD DEC
PY 2018
VL 243
BP 28
EP 36
DI 10.1016/j.envpol.2018.08.057
PN A
PG 9
WC Environmental Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology
GA HA0IN
UT WOS:000449891800004
PM 30172123
DA 2025-06-11
ER

PT J
AU Li, HW
   Beg, OU
   Rafie, AR
   Kanwal, S
   Ovalle-Cisneros, A
   Faison, MO
   Siddiqui, RA
AF Li, Haiwen
   Beg, Obaid Ullah
   Rafie, Ahmed Reza
   Kanwal, Sadia
   Ovalle-Cisneros, Alexandra
   Faison, Milton Omar
   Siddiqui, Rafat Ali
TI Characterization of Green and Yellow Papaya (Carica papaya) for
   Anti-Diabetic Activity in Liver and Myoblast Cells and Wound-Healing
   Activity in Fibroblast Cells
SO NUTRIENTS
LA English
DT Article
DE glucose uptake; polyphenols; anti-oxidation; GLUT-2; triglycerides
ID INDUCED OXIDATIVE STRESS; ANTHELMINTIC ACTIVITY; ANTIOXIDANT; OBESITY;
   EXTRACTS; LATEX; FRUIT; RISK; INFLAMMATION; INFECTIONS
AB Obesity and diabetes, often characterized as "metabolic syndrome", have been recognized as two of the most important public health issues worldwide. The objective of the present research was to evaluate green and yellow papaya for anti-oxidation and anti-diabetic properties. Leaves, skin, pulp, and seed samples from papayas were freeze-dried and then extracted in water or 80% methanol. The extracts were used to determine total polyphenolic content and anti-oxidation activities, and to determine biological activities, including glucose uptake, Glut-2 expression, triglyceride reduction, and wound-healing activity. Our data demonstrated that methanol and water extracts of green and yellow papaya have similar concentrations of polyphenols in skin (10-20 mg/g dry powder), leaf (25-30 mg/g dry powder), and pulp (1-3 mg/g dry powder) fractions. However, both methanol and water extracts of seeds from yellow papaya have substantially higher concentrations of polyphenols compared to green papaya. Both water and methanol extracts of yellow papaya exhibited higher anti-oxidation activity compared to green papaya in skin (50-60%), pulp (200-300%), and seeds (10-800%). Old leaves also showed greater anti-oxidation activity (30-40%) compared to new leaves. Pulp extracts from both yellow and green papaya stimulated greater glucose uptake, but only pulp from green papaya stimulated glucose uptake in muscle cells. Similarly, pulp extract stimulated glucose transporter Glut-2 expression in liver cells. The skin, pulp, and seeds of green or yellow papaya showed triglyceride-lowering activity in liver cells by 60-80%, but samples taken from yellow papaya had a more potent effect. Seeds from both green and yellow papaya significantly stimulated the migration of fibroblasts in the wounded area by 2-2.5-fold compared to the untreated control. Consistent with these data, seeds from both green and yellow papaya also significantly stimulated collagen synthesis in fibroblast cells by almost 3-fold. In conclusion, our data indicate that different parts of papaya produce stimulatory effects on glucose uptake, Glut-2 expression, TG reduction, and wound-healing activities. This study concludes that different parts of the papaya can be beneficial for preventing diabetes and diabetes-related wound healing.
C1 [Li, Haiwen; Beg, Obaid Ullah; Kanwal, Sadia; Siddiqui, Rafat Ali] Virginia State Univ, Coll Agr, Food Chem & Nutr Sci Lab, Agr Res Stn, Petersburg, VA 23806 USA.
   [Rafie, Ahmed Reza] Virginia State Univ, Coll Agr, Cooperate Extens, Petersburg, VA 23806 USA.
   [Ovalle-Cisneros, Alexandra; Faison, Milton Omar] Virginia State Univ, Coll Nat Sci, Dept Biol, Petersburg, VA 23806 USA.
C3 Virginia State University; Virginia State University; Virginia State
   University
RP Siddiqui, RA (corresponding author), Virginia State Univ, Coll Agr, Food Chem & Nutr Sci Lab, Agr Res Stn, Petersburg, VA 23806 USA.
EM hali@vsu.edu; obaidbeg@gmail.com; arafie@vsu.edu; skanwal@vsu.edu;
   aova7540@students.vsu.edu; mfaison@vsu.edu; rsiddiqui@vsu.edu
RI kanwal, sadia/K-5987-2019; Faison, M/GQH-9051-2022
OI kanwal, sadia/0000-0002-7455-591X; Siddiqui, Rafat/0000-0001-5936-1239
FU Evens-Allen grant; NIFA-USDA [2018-38821-27756]
FX This work was supported by an Evens-Allen grant and a Capacity Building
   grant to RAS from NIFA-USDA (2018-38821-27756).
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NR 86
TC 3
Z9 3
U1 2
U2 8
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD APR
PY 2023
VL 15
IS 8
AR 1929
DI 10.3390/nu15081929
PG 18
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA E9XB4
UT WOS:000978972700001
PM 37111148
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Arefhosseini, S
   Roshanravan, N
   Tutunchi, H
   Rostami, S
   Khoshbaten, M
   Ebrahimi-Mameghani, M
AF Arefhosseini, Sara
   Roshanravan, Neda
   Tutunchi, Helda
   Rostami, Somayyeh
   Khoshbaten, Manuchehr
   Ebrahimi-Mameghani, Mehrangiz
TI Myo-inositol supplementation improves cardiometabolic factors,
   anthropometric measures, and liver function in obese patients with
   non-alcoholic fatty liver disease
SO FRONTIERS IN NUTRITION
LA English
DT Article
DE anthropometric measures; glycemic indices; lipid profile; myo-inositol;
   non-alcoholic fatty liver disease; NAFLD; obesity
ID INSULIN-RESISTANCE; OXIDATIVE STRESS; RISK-FACTORS; INOSITOL;
   MANAGEMENT; PINITOL; PLASMA; MODEL; ACID; RATS
AB BackgroundNon-alcoholic fatty liver disease (NAFLD) as the hepatic manifestation of metabolic syndrome is closely associated with type 2 diabetes mellitus. Myo-inositol (MI)-a 6-C sugar alcohol-with insulin-mimetic, anti-diabetic, lipid-lowering, and anti-inflammatory properties has exerted favorable effects on insulin resistance-related disorders and metabolic disease, while recent animal studies revealed its positive effects on liver function. This study aimed to investigate the effects of MI supplementation on cardiometabolic factors, anthropometric measures, and liver function in obese patients with NAFLD. MethodsThis double-blinded placebo-controlled randomized clinical trial was carried out on 48 obese patients with NAFLD who were randomly assigned to either MI (4g/day) or placebo (maltodextrin 4g/day) along with dietary recommendations for 8 weeks. Glycemic indices, lipid profile, liver enzymes anthropometric measures, and blood pressure were evaluated pre- and post-intervention. Dietary intakes were assessed using a 3-day 24 h recall and analyzed by Nutritionist IV software. Insulin resistance was estimated using the homeostasis model assessment of insulin resistance (HOMA-IR), and beta-cell function (HOMA-B) was also estimated. ResultsAnthropometric measures decreased significantly in both groups, while the reduction in weight (p = 0.049) and systolic blood pressure (p = 0.006) in the MI group was significantly greater than in the placebo group after adjusting for baseline values and energy intake. Although energy and macronutrient intakes decreased significantly in both groups, between-group differences were not significant after adjusting for the potential confounders. MI supplementation led to a significant reduction in serum fasting insulin (p = 0.008) and HOMA-IR (p = 0.046). There were significant improvements in lipid profile, liver enzymes, and aspartate aminotransferase/alanine aminotransferase ratio as well as serum ferritin level in the MI group, compared to the placebo group at the endpoint. By MI supplementation for eight weeks, 1 in 3 patients reduced one- grade in the severity of NAFLD. ConclusionMI supplementation could significantly improve IR, lipid profile, and liver function in patients with NAFLD. Further clinical trials with larger sample sizes, longer duration, different MI doses, and other inositol derivatives are recommended.
C1 [Arefhosseini, Sara; Rostami, Somayyeh] Tabriz Univ Med Sci, Student Res Comm, Tabriz, Iran.
   [Roshanravan, Neda] Tabriz Univ Med Sci, Cardiovasc Res Ctr, Tabriz, Iran.
   [Tutunchi, Helda] Tabriz Univ Med Sci, Endocrine Res Ctr, Tabriz, Iran.
   [Khoshbaten, Manuchehr] Tabriz Univ Med Sci, Fac Med, Dept Internal Med, Tabriz, Iran.
   [Ebrahimi-Mameghani, Mehrangiz] Tabriz Univ Med Sci, Fac Nutr & Food Sci, Nutr Res Ctr, Dept Biochem & Diet Therapy, Tabriz, Iran.
C3 Tabriz University of Medical Science; Tabriz University of Medical
   Science; Tabriz University of Medical Science; Tabriz University of
   Medical Science; Tabriz University of Medical Science
RP Ebrahimi-Mameghani, M (corresponding author), Tabriz Univ Med Sci, Fac Nutr & Food Sci, Nutr Res Ctr, Dept Biochem & Diet Therapy, Tabriz, Iran.
EM ebrahimimamagani@tbzmed.ac.ir
RI Tutunchi, Helda/AAC-1573-2022
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NR 46
TC 10
Z9 11
U1 0
U2 5
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD FEB 7
PY 2023
VL 10
AR 1092544
DI 10.3389/fnut.2023.1092544
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 9A6CU
UT WOS:000934144900001
PM 36824177
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Calis, Z
   Dasdelen, D
   Baltaci, AK
   Mogulkoc, R
AF Calis, Zehra
   Dasdelen, Dervis
   Baltaci, Abdulkerim Kasim
   Mogulkoc, Rasim
TI Naringenin Prevents Inflammation, Apoptosis, and DNA Damage in Potassium
   Oxonate-Induced Hyperuricemia in Rat Liver Tissue: Roles of Cytochrome
   C, NF-κB, Caspase-3, and 8-Hydroxydeoxyguanosine
SO METABOLIC SYNDROME AND RELATED DISORDERS
LA English
DT Article
DE hyperuricemia; liver; naringenin; XO; IL-17; cytochrome C
ID URIC-ACID; XANTHINE-OXIDASE; OXIDATIVE STRESS; FLAVONOIDS; INHIBITORS;
   PATHWAY; CANCER; RISK; MICE
AB Background: Hyperuricemia (HU) is a metabolic disease characterized by high uric acid levels in the blood. HU is a risk factor for diabetes, cardiovascular complications, metabolic syndrome, and chronic kidney disease.Purpose: The present study was performed to determine the effect of experimental HU on xanthine oxidase (XO), tumor necrosis factor-alpha (TNF-alpha), nuclear factor-kappa B (NF-kappa B), interleukin-17 (IL-17), cytochrome C, glutathione peroxidase (GPx), caspase-3, and 8-hydroxydeoxyguanosine (8-OHdG) levels in liver tissues of rats.Study Design: Thirty-five, male, Wistar albino-type rats were used for this study. Experimental groups were formed as follows: Group 1: control group; Group 2: potassium oxonate (PO) group; group 3: PO+NAR (naringenin; 2 weeks) group; and Group 4: PO (2 weeks)+NAR (2 weeks) group (total of 4 weeks).Methods: The first group was not given anything other than normal rat food and drinking water. In the second group, a 250 mg/kg intraperitoneal dose of PO was administered for 2 weeks. In the third group, 250 mg/kg intraperitoneal PO (application for 2 weeks) and 100 mg/kg NAR intraperitoneally 1 hr after each application were administered. In the fourth group, intraperitoneal PO administration was applied for 2 weeks, followed by intraperitoneal administration of NAR for 2 weeks (4 weeks in total). At the end of the experimental period, XO, TNF-alpha, NF-kappa B, IL-17, cytochrome C, GPx, caspase-3, and 8-OHdG levels were determined in liver tissues.Results: HU increased XO, TNF-alpha, NF-kappa B, IL-17, cytochrome C, caspase-3, and 8-OHdG levels in liver tissues. However, both 2 and 4 weeks of NAR supplementation decreased these values, and also NAR supplementation led to an increase in GPx levels in tissues.Conclusions: The results of the study show that increased inflammation, apoptosis, and DNA damage in experimental HU can be prevented by administration of NAR due to inhibition of cytochrome C, NF-kappa B, caspase-3, and 8-OHdG.
C1 [Calis, Zehra; Dasdelen, Dervis; Baltaci, Abdulkerim Kasim; Mogulkoc, Rasim] Selcuk Univ, Med Fac, Dept Physiol, Konya, Turkey.
   [Mogulkoc, Rasim] Selcuk Univ, Med Fac, Dept Physiol, TR-42075 Konya, Turkey.
C3 Selcuk University; Selcuk University
RP Mogulkoc, R (corresponding author), Selcuk Univ, Med Fac, Dept Physiol, TR-42075 Konya, Turkey.
EM rasimmogulkoc@yahoo.com
RI Çalış, Zehra/GRX-7592-2022; Baltaci, Abdulkerim/ABA-7831-2020; Dasdelen,
   Dervis/MAI-2051-2025
OI Dasdelen, Dervis/0000-0002-2378-8780
FU Selcuk University Scientific Research Project Coordinatorship (SUB-AP)
   [19202068]
FX This research has been supported by the Selcuk University Scientific
   Research Project Coordinatorship (SUB-AP; Project number: 19202068).
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NR 58
TC 13
Z9 13
U1 3
U2 24
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-4196
EI 1557-8518
J9 METAB SYNDR RELAT D
JI Metab. Syndr. Relat. Disord.
PD OCT 1
PY 2022
VL 20
IS 8
BP 473
EP 479
DI 10.1089/met.2022.0028
EA JUL 2022
PG 7
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 5R0JL
UT WOS:000821904800001
PM 35796694
DA 2025-06-11
ER

PT J
AU Severance, EG
   Dickerson, F
   Yolken, RH
AF Severance, Emily G.
   Dickerson, Faith
   Yolken, Robert H.
TI Complex Gastrointestinal and Endocrine Sources of Inflammation in
   Schizophrenia
SO FRONTIERS IN PSYCHIATRY
LA English
DT Article
DE gut-brain axis; immune system; microbiome; bacterial translocation;
   metabolic syndrome
ID GLUTEN SENSITIVITY; ONSET PSYCHOSIS; IMMUNE; DISORDERS; DISEASE;
   MICROBIOME; ACTIVATION; ANTIBODIES; RISK
AB A low level, inflammatory phenotype is prevalent in individuals with schizophrenia, but the source of this inflammation is not known. Studies of the gut-brain axis indicate that this inflammation may be related to the translocation of intestinal microbes across a permeabilized gut-vasculature barrier. In addition, studies of the endocrine system support that this inflammation may derive from effects of stress hormones and metabolic imbalances. Gastrointestinal (GI) and endocrine conditions are not mutually exclusive, but rather may have additive effects to produce this inflammatory phenotype in schizophrenia. Here, we examined a series of plasma biomarkers used to measure general inflammation and presumably microbial, gut-derived inflammation in 409 individuals with schizophrenia: c-reactive protein (CRP), lipopolysaccharide-binding protein (LBP), soluble CD14 (sCD14), and IgG antibodies toS. cerevisiae, bovine milk casein, and wheat gluten. Individuals were stratified according to whether or not they had a comorbid GI or endocrine condition, both, or neither. In multivariate regression models, the presence of GI and endocrine conditions was additive for the GI-based marker, LBP, with significant associations only when both conditions were present compared to when both conditions were absent (OR = 2.32, 95(th)% CI 1.05-5.13, p < 0.03). In contrast, the marker of general inflammation, CRP, was strongly associated with primarily endocrine conditions (OR = 3.64, 95th% CI 1.35-9.84, p < 0.05). Overall associations were largely driven by the GI condition, gastroesophageal reflux disease (GERD), and by the endocrine condition, obesity. In univariate comparisons,S. cerevisiaeIgG levels were significantly elevated only in persons with GI conditions (p < 0.02), whereas antibodies to the food antigens were elevated in the presence of either or both conditions (p < 0.005-0.04). More severe psychiatric symptoms were associated only with GI conditions (p < 0.01-0.04). In conclusion, both GI and endocrine abnormalities may contribute to inflammation in schizophrenia, sometimes independently and sometimes as part of interactions which may represent complex integrated pathways. The accumulating evidence for multisystem inflammation in schizophrenia may lead to the development of new strategies to prevent and treat this devastating disorder.
C1 [Severance, Emily G.; Yolken, Robert H.] Johns Hopkins Univ, Sch Med, Dept Pediat, Stanley Div Dev Neurovirol, Baltimore, MD 21205 USA.
   [Dickerson, Faith] Sheppard Pratt Hlth Syst, Towson, MD USA.
C3 Johns Hopkins University
RP Severance, EG (corresponding author), Johns Hopkins Univ, Sch Med, Dept Pediat, Stanley Div Dev Neurovirol, Baltimore, MD 21205 USA.
EM eseverance@jhmi.edu
RI yolken, robert/AAW-2556-2021; Dickerson, Faith/C-8311-2019
FU NIMH P50 Silvio O. Conte Center at Johns Hopkins [MH-94268]; Stanley
   Medical Research Institute
FX This work was supported by a NIMH P50 Silvio O. Conte Center at Johns
   Hopkins (grant#MH-94268) and by the Stanley Medical Research Institute.
   The funding sources had no involvement in study design; collection,
   analysis and interpretation of data; in the writing of the report; and
   in the decision to submit the article for publication.
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NR 38
TC 14
Z9 15
U1 0
U2 7
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-0640
J9 FRONT PSYCHIATRY
JI Front. Psychiatry
PD JUN 16
PY 2020
VL 11
AR 549
DI 10.3389/fpsyt.2020.00549
PG 9
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA MH7OP
UT WOS:000546913900001
PM 32625121
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Rizzo, MR
   Fasano, R
   Paolisso, G
AF Rizzo, Maria Rosaria
   Fasano, Renata
   Paolisso, Giuseppe
TI Adiponectin and Cognitive Decline
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE adiponectin; cognitive function; MCI; dementia
ID BLOOD-BRAIN-BARRIER; ALZHEIMERS-DISEASE; METABOLIC SYNDROME;
   INSULIN-RESISTANCE; SERUM ADIPONECTIN; RISK; IMPAIRMENT; DEMENTIA;
   ADIPOKINES; OBESITY
AB Adiponectin (ADPN) is a plasma protein secreted by adipose tissue showing pleiotropic effects with anti-diabetic, anti-atherogenic, and anti-inflammatory properties. Initially, it was thought that the main role was only the metabolism control. Later, ADPN receptors were also found in the central nervous system (CNS). In fact, the receptors AdipoR1 and AdipoR2 are expressed in various areas of the brain, including the hypothalamus, hippocampus, and cortex. While AdipoR1 regulates insulin sensitivity through the activation of the AMP-activated protein kinase (AMPK) pathway, AdipoR2 stimulates the neural plasticity through the activation of the peroxisome proliferator-activated receptor alpha (PPAR alpha) pathway that inhibits inflammation and oxidative stress. Overall, based on its central and peripheral actions, ADPN appears to have neuroprotective effects by reducing inflammatory markers, such as C-reactive protein (PCR), interleukin 6 (IL6), and Tumor Necrosis Factor a (TNFa). Conversely, high levels of inflammatory cascade factors appear to inhibit the production of ADPN, suggesting bidirectional modulation. In addition, ADPN appears to have insulin-sensitizing action. It is known that a reduction in insulin signaling is associated with cognitive impairment. Based on this, it is of great interest to investigate the mechanism of restoration of the insulin signal in the brain as an action of ADPN, because it is useful for testing a possible pharmacological treatment for the improvement of cognitive decline. Anyway, if ADPN regulates neuronal functioning and cognitive performances by the glycemic metabolic system remains poorly explored. Moreover, although the mechanism is still unclear, women compared to men have a doubled risk of developing cognitive decline. Several studies have also supported that during the menopausal transition, the estrogen reduction can adversely affect the brain, in particular, verbal memory and verbal fluency. During the postmenopausal period, in obese and insulin-resistant individuals, ADPN serum levels are significantly reduced. Our recent study has evaluated the relationship between plasma ADPN levels and cognitive performances in menopausal women. Thus, the aim of this review is to summarize both the mechanisms and the effects of ADPN in the central nervous system and the relationship between plasma ADPN levels and cognitive performances, also in menopausal women.
C1 [Rizzo, Maria Rosaria; Fasano, Renata; Paolisso, Giuseppe] Univ Campania Luigi Vanvitelli, Dept Adv Med & Surg Sci, Piazza Miraglia 2, I-80138 Naples, Italy.
C3 Universita della Campania Vanvitelli
RP Rizzo, MR (corresponding author), Univ Campania Luigi Vanvitelli, Dept Adv Med & Surg Sci, Piazza Miraglia 2, I-80138 Naples, Italy.
EM mariarosaria.rizzo@unicampania.it; renatafasano2@gmail.com;
   giuseppe.paolisso@unicampania.it
RI Rizzo, Maria Rosaria/AHH-3649-2022; paolisso, giuseppe/AAP-8516-2020;
   Stefanadis, Christodoulos/ABH-2232-2020
OI Rizzo, Maria Rosaria/0000-0002-1023-4260; Stefanadis,
   Christodoulos/0000-0001-5974-6454
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NR 98
TC 91
Z9 93
U1 5
U2 27
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD MAR
PY 2020
VL 21
IS 6
AR 2010
DI 10.3390/ijms21062010
PG 14
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA LJ0UU
UT WOS:000529890200106
PM 32188008
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Xiong, JP
   Long, JY
   Chen, X
   Li, Y
   Song, H
AF Xiong, Jianping
   Long, Junyu
   Chen, Xi
   Li, Ye
   Song, Hai
TI Dyslipidemia Might Be Associated with an Increased Risk of
   Osteoarthritis
SO BIOMED RESEARCH INTERNATIONAL
LA English
DT Review
ID RADIOGRAPHIC KNEE OSTEOARTHRITIS; METABOLIC SYNDROME; OXIDATIVE STRESS;
   HAND OSTEOARTHRITIS; NATIONAL-HEALTH; LIPID-LEVELS; METAANALYSIS;
   CHOLESTEROL; PREVALENCE; ARTHRITIS
AB Background. According to several studies, the autoimmune response may lead to osteoarthritis and dyslipidemia and may affect the homeostasis of the human body's internal environment and then cause its own immune regulation. Consequently, the risk of osteoarthritis might be increased by dyslipidemia, but this association is not universally acknowledged. Therefore, a systematic review and meta-analysis was conducted to study the relationship between dyslipidemia and the risk of osteoarthritis. Methods. In this study, PubMed, EMBASE, and the ISI Web of Science were used to identify related studies published before July 2018. The relationship between dyslipidemia and the risk of osteoarthritis was evaluated on the basis of relative risk (RR) values and the corresponding 95% confidence intervals (CIs). To further investigate this relationship, we also employed the random effects model proposed by DerSimonian and Laird. Results. A total of nine studies were included to study the effect of dyslipidemia on the risk of osteoarthritis, including four cohort, three case-control, and two cross-sectional studies. Among these studies, six stated data for knee osteoarthritis, two reported on hand osteoarthritis, and one reported on hip osteoarthritis. A total of 53,955 participants were included in the meta-analysis, comprising 22,501 patients with OA (19,733 hand OA, 2,679 knee OA, and 89 hip OA). Based on the meta-analysis of case-control and cross-sectional studies, osteoarthritis was clearly higher in those with dyslipidemia compared to those who did not suffer from dyslipidemia (case-control: OR=1.37; 95%CI=1.27-1.46; cross-sectional: OR=1.33; 95%CI=1.21-1.46). In addition, the meta-analysis of cohort studies did not present any relationship between dyslipidemia and OA (RR=1.00; 95%CI=0.85-1.14). Conclusions. Even though our meta-analysis of case-control and cross-sectional studies suggested a strong relationship between dyslipidemia and osteoarthritis; this relationship was not validated by our meta-analysis of only cohort studies. As a result, further investigation needs to be conducted on the relationship between dyslipidemia and osteoarthritis, considering the significant public health relevance of the topic.
C1 [Xiong, Jianping; Long, Junyu; Chen, Xi; Li, Ye] Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Surg, Beijing, Peoples R China.
   [Li, Ye] Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Orthped, Beijing, Peoples R China.
   [Song, Hai] Tangshan Peoples Hosp, Dept Sci & Educ, Tangshan 063000, Peoples R China.
C3 Chinese Academy of Medical Sciences - Peking Union Medical College;
   Peking Union Medical College Hospital; Peking Union Medical College;
   Chinese Academy of Medical Sciences - Peking Union Medical College;
   Peking Union Medical College Hospital; Peking Union Medical College
RP Li, Y (corresponding author), Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Surg, Beijing, Peoples R China.; Li, Y (corresponding author), Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Orthped, Beijing, Peoples R China.; Song, H (corresponding author), Tangshan Peoples Hosp, Dept Sci & Educ, Tangshan 063000, Peoples R China.
EM 626955357@qq.com; lancet_junyu@163.com; 368198684@qq.com; liye@pumch.cn;
   songhz2018@163.com
RI Xiong, Jianping/AHD-3099-2022
OI Xiong, Jianping/0000-0001-6593-6377; Chen, Xi/0000-0003-0165-6426
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NR 46
TC 29
Z9 31
U1 0
U2 13
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2314-6133
EI 2314-6141
J9 BIOMED RES INT-UK
JI Biomed Res. Int.
PD FEB 17
PY 2020
VL 2020
AR 3105248
DI 10.1155/2020/3105248
PG 9
WC Biotechnology & Applied Microbiology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Research & Experimental Medicine
GA KS9LD
UT WOS:000518629300005
PM 32149100
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Liu, L
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   Wu, HH
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   Gao, C
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AF Liu, Liang
   Hu, Qinling
   Wu, Huihui
   Wang, Xiujing
   Gao, Chao
   Chen, Guoxun
   Yao, Ping
   Gong, Zhiyong
TI Dietary DHA/EPA Ratio Changes Fatty Acid Composition and Attenuates
   Diet-Induced Accumulation of Lipid in the Liver of ApoE<SUP>-/-</SUP>
   Mice
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Article
ID PUFA SUPPLEMENTATION; NONALCOHOLIC STEATOHEPATITIS; METABOLIC SYNDROME;
   HEPATIC STEATOSIS; PPAR-ALPHA; N-3 PUFA; DISEASE; OMEGA-3; ADIPONECTIN;
   PREVENTS
AB Diets containing various docosahexaenoic acid (DHA)/eicosapentaenoic acid (EPA) ratios protect against liver damage in mice fed with a high-fat diet (HFD). However, it is unclear whether these beneficial roles of DHA and EPA are associated with alterations of fatty acid (FA) composition in the liver. This study evaluated the positive impacts of n-6/n-3 polyunsaturated fatty acids (PUFAs) containing different DHA/EPA ratios on HFD-induced liver disease and alterations of the hepatic FA composition. ApoE(-/-) mice were fed with HFDs with various ratios of DHA/EPA (2 : 1, 1 : 1, and 1 : 2) and an n-6/n-3 ratio of 4 : 1 for 12 weeks. After treatment, the serum and hepatic FA compositions, serum biochemical parameters, liver injury, and hepatic lipid metabolism-related gene expression were determined. Our results demonstrated that dietary DHA/EPA changed serum and hepatic FA composition by increasing contents of n-6 and n-3 PUFAs and decreasing amounts of monounsaturated fatty acids (MUFAs) and the n-6/n-3 ratio. Among the three DHA/EPA groups, the DHA/EPA 2 : 1 group tended to raise n-3 PUFAs concentration and lower the n-6/n-3 ratio in the liver, whereas DHA/EPA 1 : 2 tended to raise n-6 PUFAs concentration and improve the n-6/n-3 ratio. DHA/EPA supplementation reduced the hepatic impairment of lipid homeostasis, oxidative stress, and the inflammatory responses in HFD-fed mice. The DHA/EPA 2 : 1 group had lower serum levels of total cholesterol, triglycerides, and low-density lipoprotein cholesterol and higher levels of adiponectin than HFD group. The DHA/EPA 1 : 2 group had elevated serum levels of aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase, without significant change the expression of genes for inflammation or hepatic lipid metabolism among the three DHA/EPA groups. The results suggest that DHA/EPA-enriched diet with an n-6/n-3 ratio of 4 : 1 may reverse HFD-induced nonalcoholic fatty liver disease to some extent by increasing n-6 and n-3 PUFAs and decreasing the amount of MUFAs and the n-6/n-3 ratio.
C1 [Liu, Liang; Hu, Qinling; Wu, Huihui; Wang, Xiujing; Gong, Zhiyong] Minist Educ, Key Lab Deep Proc Major Grain & Oil, Wuhan 430023, Hubei, Peoples R China.
   [Liu, Liang; Hu, Qinling; Wu, Huihui; Wang, Xiujing; Gong, Zhiyong] Wuhan Polytech Univ, Coll Food Sci & Engn, Wuhan 430023, Hubei, Peoples R China.
   [Liu, Liang; Gong, Zhiyong] Wuhan Polytech Univ, Hubei Key Lab Proc & Transformat Agr Prod, Wuhan 430023, Hubei, Peoples R China.
   [Gao, Chao] Chinese Ctr Dis Control & Prevent, Natl Inst Nutr & Hlth, Beijing 100050, Peoples R China.
   [Chen, Guoxun] Univ Tennessee, Dept Nutr, Knoxville, TN 37996 USA.
   [Yao, Ping] Huazhong Univ Sci & Technol, Sch Publ Hlth, Dept Nutr & Food Hyg, Tongji Med Coll, Wuhan 430030, Hubei, Peoples R China.
C3 Ministry of Education - China; Wuhan Polytechnic University; Wuhan
   Polytechnic University; Chinese Center for Disease Control & Prevention;
   University of Tennessee System; University of Tennessee Knoxville;
   Huazhong University of Science & Technology
RP Gong, ZY (corresponding author), Minist Educ, Key Lab Deep Proc Major Grain & Oil, Wuhan 430023, Hubei, Peoples R China.; Gong, ZY (corresponding author), Wuhan Polytech Univ, Coll Food Sci & Engn, Wuhan 430023, Hubei, Peoples R China.; Gong, ZY (corresponding author), Wuhan Polytech Univ, Hubei Key Lab Proc & Transformat Agr Prod, Wuhan 430023, Hubei, Peoples R China.
EM gongwhpu@126.com
RI Liu, Liang/AAG-9705-2019; GAO, Chao/AAM-3839-2020; li, yan/GXH-7943-2022
OI Chen, Guoxun/0000-0001-6226-4050; Liu, Liang/0000-0002-1423-4997; Yao,
   Ping/0000-0002-0192-9546
FU National Key Research and Development Program of China [2017YFC1600500];
   National High-Tech Research and Development Projects [2010AA023003];
   National Natural Science Foundation of China [31201351]; Young Elite
   Scientists Sponsorship Program by CAST (China Association for Science
   and Technology) [YESS20160164]; Chinese Nutrition Society DSM Research
   Fund
FX This work was supported by the National Key Research and Development
   Program of China (no. 2017YFC1600500), the National High-Tech Research
   and Development Projects (no. 2010AA023003), the National Natural
   Science Foundation of China (no. 31201351), the Young Elite Scientists
   Sponsorship Program by CAST (China Association for Science and
   Technology) (no. YESS20160164), and the 2015 Chinese Nutrition Society
   DSM Research Fund. We would like to thank LetPub for English language
   editing.
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NR 44
TC 24
Z9 24
U1 1
U2 23
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PY 2018
VL 2018
AR 6256802
DI 10.1155/2018/6256802
PG 12
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA HB6LR
UT WOS:000451181700001
PM 30538803
OA Green Published, Green Submitted, hybrid
DA 2025-06-11
ER

PT J
AU Zong, CL
   Song, GH
   Yao, ST
   Guo, SD
   Yu, Y
   Yang, NN
   Guo, Z
   Qin, SC
AF Zong, Chuanlong
   Song, Guohua
   Yao, Shutong
   Guo, Shoudong
   Yu, Yang
   Yang, Nana
   Guo, Zheng
   Qin, Shucun
TI Cigarette smoke exposure impairs reverse cholesterol transport which can
   be minimized by treatment of hydrogen-saturated saline
SO LIPIDS IN HEALTH AND DISEASE
LA English
DT Article
DE Cigarette smoke exposure; Hydrogen; Reverse cholesterol transport;
   High-density lipoprotein; Human CETP transgenic mice
ID HIGH-DENSITY-LIPOPROTEIN; ESTER TRANSFER PROTEIN; E KNOCKOUT MICE;
   OXIDATIVE MODIFICATION; SCAVENGER RECEPTOR; TRANSGENIC MICE; PLASMA
   LECITHIN; TOBACCO-SMOKE; EFFLUX; BINDING
AB Background: Cigarette smoke (CS) exposure impaired plasma lipid profiles by modification of apolipoproteins. Hydrogen (H-2) has been proved effective on reducing oxidative stress or improving HDL functionalities in animal models or metabolic syndrome volunteers. This study was undertaken to explore the effects of CS exposure on reverse cholesterol transport (RCT) and the antioxidative effects of H-2 treatment against CS exposure in mice transgenic for human cholesteryl ester transfer protein (CETP).
   Methods: [H-3]-cholesterol-laden macrophages were injected intraperitoneally into mice, and the samples of blood, bile, liver, and feces were collected for radioactivity determination to evaluate RCT. [H-3]-cholesterol-laden macrophages were incubated with HDL isolated from different groups of mice, and the samples of cell medium supernatants were collected for evaluating the HDL functionality to elicit cholesterol efflux.
   Results: CS exposure significantly decreased plasma HDL cholesterol level (HDL-C) by 22 % and increased LDL cholesterol level (LDL-C) by 21 % compared with the control group (p < 0.05, p < 0.01), while H-2 treatment significantly improved the CS-impaired levels of TC, LDL-C and HDL-C by 10, 27 and 31 %, respectively, compared with the CS group (p < 0.05, p < 0.01 and p < 0.05). Besides, CS exposure significantly decreased [H-3] tracer concentrations in liver, bile and feces by 17, 35 and 48 %, respectively, compared with the control group (p < 0.05 for liver and feces), while H-2 treatment significantly improved them by 21, 72 % and 89 %, respectively, compared with the CS group (all p < 0.05). Furthermore, CS exposure significantly decreased the HDL functionality to elicit cholesterol efflux by 26 % (p < 0.05), while H-2 treatment also improved it by 32 % (p < 0.05). We did not find any significant alterations in protein expressions of RCT involved genes.
   Conclusions: These findings provided direct evidence supporting the notion that CS exposure in vivo impairs plasma lipid profiles, HDL functionalities and macrophage-to-feces RCT pathway in CETP transgenic mice, all of which can be minimized by treatment of H-2-saturated saline.
C1 [Zong, Chuanlong; Song, Guohua; Yao, Shutong; Guo, Shoudong; Yu, Yang; Yang, Nana; Qin, Shucun] Taishan Med Univ, Inst Atherosclerosis, Key Lab Atherosclerosis Univ Shandong Prov, Tai An 271000, Shandong, Peoples R China.
   [Guo, Zheng] Taishan Med Univ, Sch Basic Med Sci, Tai An 271000, Shandong, Peoples R China.
C3 Taishan University; Shandong First Medical University & Shandong Academy
   of Medical Sciences; Shandong First Medical University & Shandong
   Academy of Medical Sciences; Taishan University
RP Zong, CL (corresponding author), Taishan Med Univ, Inst Atherosclerosis, Key Lab Atherosclerosis Univ Shandong Prov, 2 Yingsheng East Rd, Tai An 271000, Shandong, Peoples R China.
EM chlzong@tsmc.edu.cn; shucunqin@hotmail.com
RI Guo, Zheng/JHT-9665-2023
OI GUO, ZHENG/0000-0003-2105-4537
FU Shandong Provincial Natural Science Foundation, China [ZR2012HM034];
   Taishan Scholars Foundation of Shandong Province [200811]; National
   Natural Science Foundation of China [81200216]; Promotive Research Fund
   for Excellent Young and Middle-aged Scientists of Shandong Province,
   China [BS2012YY034]
FX The present study was supported by Shandong Provincial Natural Science
   Foundation, China (ZR2012HM034) for C Z, the Taishan Scholars Foundation
   of Shandong Province (200811) for S Q, the National Natural Science
   Foundation of China (81200216) and the Promotive Research Fund for
   Excellent Young and Middle-aged Scientists of Shandong Province, China
   (BS2012YY034) for GS.
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NR 44
TC 19
Z9 20
U1 1
U2 6
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1476-511X
J9 LIPIDS HEALTH DIS
JI Lipids Health Dis.
PD DEC 3
PY 2015
VL 14
AR 159
DI 10.1186/s12944-015-0160-9
PG 10
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA CX6WE
UT WOS:000365841600002
PM 26634341
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Roriz, JS
   Sá-Roriz, TM
   Rosset, I
   Camozzato, AL
   Santos, AC
   Chaves, MLF
   Moriguti, JC
   Roriz-Cruz, M
AF Roriz-Filho, Jarbas S.
   Sa-Roriz, Ticiana M.
   Rosset, Idiane
   Camozzato, Ana L.
   Santos, Antonio C.
   Chaves, Marcia L. F.
   Moriguti, Julio Cesar
   Roriz-Cruz, Matheus
TI (Pre)diabetes, brain aging, and cognition
SO BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
LA English
DT Review
DE Diabetes; Insulin; 'Brain aging'; Cognition; Dementia
ID IMPAIRED GLUCOSE-TOLERANCE; AMYLOID-BETA-PROTEIN; HIPPOCAMPAL SYNAPTIC
   PLASTICITY; STREPTOZOTOCIN-DIABETIC RATS; GLYCOGEN-SYNTHASE KINASE-3;
   INSULIN-DEGRADING ENZYME; GROWTH-FACTOR EXPRESSION; C-REACTIVE PROTEIN;
   ALZHEIMERS-DISEASE; RISK-FACTORS
AB Cognitive dysfunction and dementia have recently been proven to be common (and underrecognized) complications of diabetes mellitus (DM). In fact, several studies have evidenced that phenotypes associated with obesity and/or alterations on insulin homeostasis are at increased risk for developing cognitive decline and dementia, including not only vascular dementia, but also Alzheimer's disease (AD). These phenotypes include prediabetes, diabetes, and the metabolic syndrome. Both types I and 2 diabetes are also important risk factors for decreased performance in several neuropsychological functions. Chronic hyperglycemia and hyperinsulinemia primarily stimulates the formation of Advanced Glucose Endproducts (AGEs), which leads to an overproduction of Reactive Oxygen Species (ROS). Protein glycation and increased oxidative stress are the two main mechanisms involved in biological aging, both being also probably related to the etiopathogeny of AD. AD patients were found to have lower than normal cerebrospinal fluid levels of insulin. Besides its traditional glucoregulatory importance, insulin has significant neurothrophic properties in the brain. How can clinical hyperinsulinism be a risk factor for AD whereas lab experiments evidence insulin to be an important neurothrophic factor? These two apparent paradoxal findings may be reconciliated by evoking the concept of insulin resistance. Whereas insulin is clearly neurothrophic at moderate concentrations, too much insulin in the brain may be associated with reduced amyloid-beta (A beta) clearance due to competition for their common and main depurative mechanism - the Insulin-Degrading Enzyme (IDE). Since IDE is much more selective for insulin than for A beta, brain hyperinsulinism may deprive A beta of its main clearance mechanism. Hyperglycemia and hyperinsulinemia seems to accelerate brain aging also by inducing tau hyperphosphorylation and amyloid oligomerization, as well as by leading to widespread brain microangiopathy. In fact, diabetes subjects are more prone to develop extense and earlier-than-usual leukoaraiosis (White Matter High-intensity Lesions - WMHL). WMHL are usually present at different degrees in brain scans of elderly people. People with more advanced WMHL are at increased risk for executive dysfunction, cognitive impairment and dementia. Clinical phenotypes associated with insulin resistance possibly represent true clinical models for brain and systemic aging. (C) 2008 Elsevier B.V. All rights reserved.
C1 [Roriz-Filho, Jarbas S.; Santos, Antonio C.; Moriguti, Julio Cesar] Univ Sao Paulo RP, Fac Med, Dept Internal Med, Div Geriatr, Sao Paulo, Brazil.
   [Roriz-Filho, Jarbas S.; Santos, Antonio C.; Moriguti, Julio Cesar] Univ Sao Paulo RP, Fac Med, Dept Internal Med, Div Neuroimage, Sao Paulo, Brazil.
   [Sa-Roriz, Ticiana M.] Univ Sao Paulo RP, Dept Psychol, Sao Paulo, Brazil.
   [Rosset, Idiane] Univ Sao Paulo RP, Fac Nursing, Div Gerontol Nursing, Sao Paulo, Brazil.
   [Camozzato, Ana L.; Chaves, Marcia L. F.; Roriz-Cruz, Matheus] Brazilian Fed Univ Rio Grande do Sul State, Fac Med, Dept Neurol, Div Neurogeriatr, Porto Alegre, RS, Brazil.
C3 Universidade de Sao Paulo; Universidade de Sao Paulo; Universidade de
   Sao Paulo; Universidade de Sao Paulo; Universidade Federal do Rio Grande
   do Sul
RP Roriz-Cruz, M (corresponding author), Hosp Clin, Dept Neurol, 3rd Floor,Ramiro Barcelos St 2350, BR-90035903 Porto Alegre, RS, Brazil.
EM mcruz@hcpa.ufrgs.br
RI Moriguti, Julio/P-7207-2016; Santos, Antonio/F-5419-2012; Chaves,
   Marcia/K-8353-2014
OI Moriguti, Julio/0000-0001-5499-3552; Chaves, Marcia/0000-0002-1940-4043;
   Roriz Filho, Jarbas/0000-0002-5928-0399
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NR 223
TC 289
Z9 323
U1 2
U2 39
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0925-4439
EI 1879-260X
J9 BBA-MOL BASIS DIS
JI Biochim. Biophys. Acta-Mol. Basis Dis.
PD MAY
PY 2009
VL 1792
IS 5
SI SI
BP 432
EP 443
DI 10.1016/j.bbadis.2008.12.003
PG 12
WC Biochemistry & Molecular Biology; Biophysics; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Biochemistry & Molecular Biology; Biophysics; Cell Biology
GA 444CC
UT WOS:000265956700007
PM 19135149
OA Bronze, Green Submitted
DA 2025-06-11
ER

PT J
AU Larsson, CA
   Gullberg, B
   Råstam, L
   Lindblad, U
AF Larsson, Charlotte A.
   Gullberg, Bo
   Rastam, Lennart
   Lindblad, Ulf
TI Salivary cortisol differs with age and sex and shows inverse
   associations with WHR in Swedish women: a cross-sectional study
SO BMC ENDOCRINE DISORDERS
LA English
DT Article
ID PITUITARY-ADRENAL AXIS; BODY-FAT DISTRIBUTION; ABDOMINAL VISCERAL FAT;
   METABOLIC SYNDROME; OBESE WOMEN; CARDIOVASCULAR-DISEASE;
   GENDER-DIFFERENCES; NERVOUS-SYSTEM; SECRETION; STRESS
AB Background: Most studies on cortisol have focused on smaller, selected samples. We therefore aimed to sex-specifically study the diurnal cortisol pattern and explore its association with abdominal obesity in a large unselected population.
   Methods: In 2001-2004, 1811 men and women (30-75 years) were randomly selected from the Vara population, south-western Sweden (81% participation rate). Of these, 1671 subjects with full information on basal morning and evening salivary cortisol and anthropometric measurements were included in this cross-sectional study. Differences between groups were examined by general linear model and by logistic and linear regression analyses.
   Results: Morning and Delta-cortisol (morning - evening cortisol) were significantly higher in women than men. In both genders older age was significantly associated with higher levels of all cortisol measures, however, most consistently with evening cortisol. In women only, age-adjusted means of WHR were significantly lower in the highest compared to the lowest quartile of morning cortisol (p = 0.036) and Delta-cortisol (p < 0.001), respectively. Furthermore, when comparing WHR above and below the mean, the age-adjusted OR in women for the lowest quartile of cortisol compared to the highest was 1.5 (1.0-2.2, p = 0.058) for morning cortisol and 1.9 (1.3-2.8) for Delta-cortisol. All findings for Delta-cortisol remained after adjustments for multiple covariates and were also seen in a linear regression analysis (p = 0.003).
   Conclusion: In summary, our findings of generally higher cortisol levels in women than men of all ages are novel and the stronger results seen for Delta-cortisol as opposed to morning cortisol in the association with WHR emphasise the need of studying cortisol variation intra-individually. To our knowledge, the associations in this study have never before been investigated in such a large population sample of both men and women. Our results therefore offer important knowledge on the descriptive characteristics of cortisol in relation to age and gender, and on the impact that associations previously seen between cortisol and abdominal obesity in smaller, selected samples have on a population level.
C1 [Larsson, Charlotte A.; Gullberg, Bo; Rastam, Lennart] Lund Univ, Dept Clin Sci, Malmo, Sweden.
   [Lindblad, Ulf] Gothenburg Univ, Sahlgrenska Acad, Dept Publ Hlth & Community Med Primary Hlth Care, Gothenburg, Sweden.
   [Lindblad, Ulf] Skaraborg Inst, Skovde, Sweden.
C3 Lund University; University of Gothenburg
RP Larsson, CA (corresponding author), Lund Univ, Dept Clin Sci, Malmo, Sweden.
EM charlotte_a.larsson@med.lu.se; bo.gullberg@med.lu.se;
   lennart.rastam@med.lu.se; ulf.lindblad@med.lu.se
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NR 40
TC 127
Z9 151
U1 0
U2 12
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1472-6823
J9 BMC ENDOCR DISORD
JI BMC Endocr. Disord.
PY 2009
VL 9
AR 16
DI 10.1186/1472-6823-9-16
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA V20CX
UT WOS:000208119200016
PM 19545400
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Drummer, C
   Saaoud, F
   Jhala, NC
   Cueto, R
   Sun, Y
   Xu, KM
   Shao, Y
   Lu, YF
   Shen, HM
   Yang, L
   Zhou, Y
   Yu, J
   Wu, S
   Snyder, NW
   Hu, WH
   Zhuo, JJ
   Zhong, YH
   Jiang, XH
   Wang, H
   Yang, XF
AF Drummer, Charles
   Saaoud, Fatma
   Jhala, Nirag C.
   Cueto, Ramon
   Sun, Yu
   Xu, Keman
   Shao, Ying
   Lu, Yifan
   Shen, Huimin
   Yang, Ling
   Zhou, Yan
   Yu, Jun
   Wu, Sheng
   Snyder, Nathaniel W.
   Hu, Wenhui
   Zhuo, Jia Joe
   Zhong, Yinghui
   Jiang, Xiaohua
   Wang, Hong
   Yang, Xiaofeng
TI Caspase-11 promotes high-fat diet-induced NAFLD by increasing
   glycolysis, OXPHOS, and pyroptosis in macrophages
SO FRONTIERS IN IMMUNOLOGY
LA English
DT Article
DE non-alcoholic fatty liver disease (NAFLD); non-alcoholic steatohepatitis
   (NASH); caspase-11; inflammation; pyroptosis
ID LIVER-DISEASE; NONALCOHOLIC STEATOHEPATITIS; ENDOTHELIAL-CELLS;
   INFLAMMASOME ACTIVATION; UNITED-STATES; FIBROSIS; EXPRESSION; BURDEN;
   DIFFERENTIATION; CENICRIVIROC
AB Introduction: Non-alcoholic fatty liver disease (NAFLD) has a global prevalence of 25% of the population and is a leading cause of cirrhosis and hepatocellular carcinoma. NAFLD ranges from simple steatosis (non-alcoholic fatty liver) to non-alcoholic steatohepatitis (NASH). Hepatic macrophages, specifically Kupffer cells (KCs) and monocyte-derived macrophages, act as key players in the progression of NAFLD. Caspases are a family of endoproteases that provide critical connections to cell regulatory networks that sense disease risk factors, control inflammation, and mediate inflammatory cell death (pyroptosis). Caspase-11 can cleave gasdermin D (GSDMD) to induce pyroptosis and specifically defends against bacterial pathogens that invade the cytosol. However, it's still unknown whether high fat diet (HFD)-facilitated gut microbiota- generated cytoplasmic lipopolysaccharides (LPS) activate caspase-11 and promote NAFLD.
   Methods: To examine this hypothesis, we performed liver pathological analysis, RNA- seq, FACS, Western blots, Seahorse mitochondrial stress analyses of macrophages and bone marrow transplantation on HFD-induced NAFLD in WT and Casp11-/- mice.
   Results and Discussion: Our results showed that 1) HFD increases body wight, liver wight, plasma cholesterol levels, liver fat deposition, and NAFLD activity score (NAS score) in wild-type (WT) mice; 2) HFD increases the expression of caspase-11, GSDMD, interleukin-1b, and guanylate-binding proteins in WT mice; 3) Caspase-11 deficiency decreases fat liver deposition and NAS score; 4) Caspase-11 deficiency decreases bone marrow monocyte-derived macrophage (MDM) pyroptosis (inflammatory cell death) and inflammatory monocyte ( IM) surface GSDMD expression; 5) Caspase-11 deficiency re- programs liver transcriptomes and reduces HFD-induced NAFLD; 6) Caspase-11 deficiency decreases extracellular acidification rates (glycolysis) and oxidative phosphorylation (OXPHOS) in inflammatory fatty acid palmitic acid-stimulated macrophages, indicating that caspase-11 significantly contributes to maintain dual fuel bioenergetics-glycolysis and OXPHOS for promoting pyroptosis in macrophages. These results provide novel insights on the roles of the caspase- 11-GSDMD pathway in promoting hepatic macrophage inflammation and pyroptosis and novel targets for future therapeutic interventions involving the transition of NAFLD to NASH, hyperlipidemia, type II diabetes, metabolic syndrome, metabolically healthy obesity, atherosclerotic cardiovascular diseases, autoimmune diseases, liver transplantation, and hepatic cancers.
C1 [Drummer, Charles; Saaoud, Fatma; Sun, Yu; Xu, Keman; Shao, Ying; Lu, Yifan; Yang, Xiaofeng] Temple Univ, Ctr Cardiovasc Res, Lewis Katz Sch Med, Philadelphia, PA 19122 USA.
   [Jhala, Nirag C.] Temple Univ, Dept Pathol & Lab Med, Lewis Katz Sch Med, Philadelphia, PA USA.
   [Cueto, Ramon; Shen, Huimin; Yu, Jun; Wu, Sheng; Snyder, Nathaniel W.; Hu, Wenhui; Jiang, Xiaohua; Wang, Hong; Yang, Xiaofeng] Temple Univ, Metab Dis Res & Thrombosis Res Ctr, Dept Cardiovasc Sci, Lewis Katz Sch Med, Philadelphia, PA 19122 USA.
   [Yang, Ling] Temple Univ, Dept Med Genet & Mol Biochem, Lewis Katz Sch Med, Philadelphia, PA USA.
   [Zhou, Yan] Temple Hlth, Fox Chase Canc Ctr, Biostat & Bioinformat Facil, Philadelphia, PA USA.
   [Zhuo, Jia Joe] Tulane Univ, Tulane Hypertens & Renal Ctr Excellence, Sch Med, New Orleans, LA USA.
   [Zhong, Yinghui] Drexel Univ, Sch Biomed Engn Sci & Hlth Syst, Philadelphia, PA USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE); Temple
   University; Pennsylvania Commonwealth System of Higher Education
   (PCSHE); Temple University; Pennsylvania Commonwealth System of Higher
   Education (PCSHE); Temple University; Pennsylvania Commonwealth System
   of Higher Education (PCSHE); Temple University; Fox Chase Cancer Center;
   Tulane University; Drexel University
RP Yang, XF (corresponding author), Temple Univ, Ctr Cardiovasc Res, Lewis Katz Sch Med, Philadelphia, PA 19122 USA.; Yang, XF (corresponding author), Temple Univ, Metab Dis Res & Thrombosis Res Ctr, Dept Cardiovasc Sci, Lewis Katz Sch Med, Philadelphia, PA 19122 USA.
EM xfyang@temple.edu
RI SUN, YU/ABE-7355-2021; 仲, 英惠/HZH-3357-2023; XU, KEMAN/JJC-6529-2023;
   shen, huimin/LUY-0510-2024
OI Lu, Yifan/0000-0003-4461-0698; Hu, Wenhui/0000-0001-8152-6116
FU National Institutes of Health (NIH)/National Heart, Lung, and Blood
   Institute [HL131460, HL132399, HL138749, HL147565, DK104116, DK113775]
FX Funding Our research activities are supported by grants from the
   National Institutes of Health (NIH)/National Heart, Lung, and Blood
   Institute (HL131460, HL132399, HL138749, HL147565, DK104116, and
   DK113775). The content in this article is solely the responsibility of
   the authors and does not necessarily represent the official views of the
   NIH. We are very grateful to Dr. Edward A. Miao in the Department of
   Immunology at Duke University School of Medicine for his most insightful
   advices and corrections.
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NR 145
TC 42
Z9 43
U1 7
U2 37
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-3224
J9 FRONT IMMUNOL
JI Front. Immunol.
PD JAN 26
PY 2023
VL 14
AR 1113883
DI 10.3389/fimmu.2023.1113883
PG 17
WC Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology
GA 8S7JS
UT WOS:000928753600001
PM 36776889
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Moghadam, BH
   Bagheri, R
   Ghanavati, M
   Khodadadi, F
   Cheraghloo, N
   Wong, ALX
   Nordvall, M
   Suzuki, K
   Shabkhiz, F
AF Hooshmand Moghadam, Babak
   Bagheri, Reza
   Ghanavati, Matin
   Khodadadi, Fatemeh
   Cheraghloo, Neda
   Wong, Alexei
   Nordvall, Michael
   Suzuki, Katsuhiko
   Shabkhiz, Fatemeh
TI The Combined Effects of 6 Weeks of Jump Rope Interval Exercise and Dark
   Chocolate Consumption on Antioxidant Markers in Obese Adolescent Boys
SO ANTIOXIDANTS
LA English
DT Article
DE antioxidants; dark chocolate; body composition; obesity; metabolic
   syndrome
ID OXIDATIVE STRESS RESPONSES; WEIGHT-LOSS; ADIPOSE-TISSUE; MITOCHONDRIAL
   BIOGENESIS; INSULIN SENSITIVITY; VITAMIN-C; IMPROVES; INFLAMMATION;
   RESTRICTION; RESISTANCE
AB Research has shown that both dark chocolate and exercise training may have favorable effects on antioxidant function in obese cohorts. However, their combined effect has not been established. We assessed the influences of six weeks of dark chocolate consumption combined with jump rope exercise on antioxidant markers in adolescent boys with obesity. Fifty adolescent boys with obesity (age = 15 & PLUSMN; 1 years) were randomly assigned into one of four groups; jump rope exercise + white chocolate consumption (JW; n = 13), jump rope exercise + dark chocolate consumption (JD; n = 13), dark chocolate consumption (DC; n = 12), or control (C; n = 12). Two participants dropped out of the study. Participants in JW and JD groups performed jump rope exercise three times per week for six weeks. Participants in the DC and JD groups consumed 30 g of dark chocolate containing 83% of cocoa during the same period. Serum concentrations of superoxide dismutase (SOD), total antioxidant capacity (TAC), glutathione peroxidase (GPx), and thiobarbituric acid reactive substances (TBARS) were evaluated prior to and after the interventions. All 3 intervention groups noted significant (p < 0.01) increases in serum concentrations of TAC, SOD, and GPx from baseline to post-test. In contrast, all intervention groups showed significantly reduced serum concentrations of TBARS from pre- to post-test (p & LE; 0.01). Bonferroni post hoc analysis revealed that post-test serum concentrations of TAC in the JD group were significantly greater than C (p < 0.001), DC (p = 0.010), and JW (p < 0.001) groups. In addition, post-test serum concentrations of SOD in the JD group were significantly greater than C group (p = 0.001). Post-test serum concentrations of GPx in the JD group were significantly greater than C (p < 0.001), DC (p = 0.021), and JW (p = 0.032) groups. The post-test serum concentrations of TBARS in the JD group was significantly lower than C (p < 0.001). No other significant between-group differences were observed. The current study provides evidence that dark chocolate consumption in combination with jump rope exercise is more efficient in improving antioxidant capacity than dark chocolate consumption or jump rope exercise alone among obese adolescent boys.
C1 [Hooshmand Moghadam, Babak; Khodadadi, Fatemeh; Shabkhiz, Fatemeh] Ferdowsi Univ Mashhad, Dept Exercise Physiol, Mashhad 9177948974, Razavi Khorasan, Iran.
   [Hooshmand Moghadam, Babak] Univ Tehran, Dept Exercise Physiol, Tehran 1961733114, Iran.
   [Bagheri, Reza] Univ Isfahan, Dept Exercise Physiol, Esfahan 8174673441, Iran.
   [Ghanavati, Matin] Shahid Beheshti Univ Med Sci, Natl Nutr & Food Technol Res Inst, Fac Nutr Sci & Food Technol, Tehran 1416753955, Iran.
   [Cheraghloo, Neda] Univ Tehran Med Sci, Sch Publ Hlth, Dept Epidmiol & Biostat, Tehran 1417613151, Iran.
   [Wong, Alexei; Nordvall, Michael] Marymount Univ, Dept Hlth & Human Performance, Arlington, VA 22207 USA.
   [Suzuki, Katsuhiko] Waseda Univ, Fac Sport Sci, 2-579-15 Mikajima, Tokorozawa, Saitama 3591192, Japan.
C3 Ferdowsi University Mashhad; University of Tehran; University of
   Isfahan; Shahid Beheshti University Medical Sciences; Tehran University
   of Medical Sciences; Marymount University; Waseda University
RP Shabkhiz, F (corresponding author), Ferdowsi Univ Mashhad, Dept Exercise Physiol, Mashhad 9177948974, Razavi Khorasan, Iran.; Suzuki, K (corresponding author), Waseda Univ, Fac Sport Sci, 2-579-15 Mikajima, Tokorozawa, Saitama 3591192, Japan.
EM babak.hooshmand@mail.um.ac.ir; reza.bagheri@alumni.um.ac.ir;
   matinghanavati@sbmu.ac.ir; Fateme.khodadadi@mail.um.ac.ir;
   n-cheraghloo@razi.tums.ac.ir; awong@marymount.edu;
   mnordval@marymount.edu; katsu.suzu@waseda.jp; Shabkhiz@ut.ac.ir
RI Hooshmand, Babak/LKJ-7311-2024; shabkhiz, fatemeh/ABH-2559-2020;
   Ghanavati, Matin/AAD-6617-2022
OI Hooshmand Moghadam, Babak/0000-0002-2036-9492; Suzuki,
   Katsuhiko/0000-0002-6572-5809; Ghanavati, Matin/0000-0001-7447-3845;
   khodadadi, fatemeh/0000-0001-5653-3920; Nordvall,
   Michael/0000-0003-1100-478X; cheraghloo, neda/0000-0003-1924-3435; Wong,
   Alexei/0000-0003-2695-8850
FU Department of Exercise Physiology, University of Tehran, Tehran, Iran
   [1397]
FX This study was supported by Department of Exercise Physiology,
   University of Tehran, Tehran, Iran. (Grant number: 1397).
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NR 81
TC 5
Z9 5
U1 0
U2 14
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD NOV
PY 2021
VL 10
IS 11
AR 1675
DI 10.3390/antiox10111675
PG 16
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA XL2NH
UT WOS:000727985400001
PM 34829546
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Egea, MB
   Pierce, G
   Becraft, AR
   Sturm, M
   Yu, W
   Shay, NF
AF Egea, Mariana Buranelo
   Pierce, Gavin
   Becraft, Alexandra R.
   Sturm, Marlena
   Yu, Wesley
   Shay, Neil F.
TI Intake of Watermelon and Watermelon Byproducts in Male Mice Fed a
   Western-Style Obesogenic Diet Alters Hepatic Gene Expression Patterns,
   as Determined by RNA Sequencing
SO CURRENT DEVELOPMENTS IN NUTRITION
LA English
DT Article
DE watermelon; RNA sequencing; obesity; diabetes; metabolic syndrome; mice;
   nuclear hormone receptors
ID NUCLEAR RECEPTOR; TARGET GENES; X RECEPTOR; LIVER; STRESS; CHOLESTEROL;
   LYCOPENE; BINDING; OBESITY; NAFLD
AB Background: Consumption of watermelon has been associated with beneficial effects on metabolism, including reductions in systolic blood pressure, improved fasting blood glucose levels, and changes in hepatic metabolite accumulation.
   Objectives: In the present study, we investigated the impact of consumption of watermelon flesh (WF), watermelon rind (WR), and watermelon skin (WS) on hepatic gene expression patterns in an obesogenic mouse model.
   Methods: Hepatic RNA was isolated and RNA sequencing was performed following a 10-week feeding trial during which C57BL/6 J mice were provided either a low-fat diet (LF), high-fat diet (HF; controls), or HF plus either WS, WR, or WF. Bioinformatic approaches were used to determine changes in the canonical pathways and gene expression levels for lipid- and xenobiotic-regulating nuclear hormone receptors and other related transcription factors, including the aryl hydrocarbon receptor (AhR), constitutive androstane receptor (CAR), farnesyl X receptor, peroxisome proliferator-activated receptor alpha (PPARa), peroxisome proliferator-activated receptor gamma, liver X receptor, pregnane X receptor, and nuclear factor erythroid 2-related factor 2.
   Results: There were 9394 genes that had unchanged expression levels between all 5 diet groups, and 247, 58, and 34 genes were uniquely expressed in the WF, WR, and WS groups, respectively. The relative levels of mRNAs regulated by AhR, CAR, and PPARa were upregulated in mice in the WF group, as compared to the HF control mice; in comparison, mRNAs regulated mainly by CAR were upregulated in mice in the WR and WS groups, compared to those in the HF control group.
   Conclusions: At modest levels of intake reflective of typical human consumption, mice in the WF, WS, and WR groups exhibited hepatic gene expression profiles that were altered when compared to mice in the HF control group. Several of these changes involve genes regulated by ligand-responsive transcription factors implicated in xenobiotic and lipid metabolisms, suggesting that the modulation of these transcription factors occurred in response to the consumption of WS, WR, and WF. Some of these changes are likely due to nuclear hormone receptor-mediated changes involved in lipid and xenobiotic metabolisms.
C1 [Egea, Mariana Buranelo] Inst Fed Educ Ciencia & Tecnol Goiano, Food Sci & Technol, Goiano, Brazil.
   [Egea, Mariana Buranelo; Pierce, Gavin; Becraft, Alexandra R.; Sturm, Marlena; Yu, Wesley; Shay, Neil F.] Oregon State Univ, Food Sci & Technol, Corvallis, OR 97331 USA.
C3 Instituto Federal Goiano; Oregon State University
RP Shay, NF (corresponding author), Oregon State Univ, Food Sci & Technol, Corvallis, OR 97331 USA.
EM neil.shay@oregonstate.edu
RI Egea, Mariana/B-1889-2014
OI Yu, Wesley/0000-0001-9593-9560
FU National Watermelon Promotion Board
FX This work was supported by the National Watermelon Promotion Board. This
   organization had no role in the design, implementation, analysis, nor
   interpretation of the data.
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NR 46
TC 5
Z9 5
U1 0
U2 7
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 2475-2991
J9 CURR DEV NUTR
JI Curr. Dev. Nutr.
PD AUG
PY 2020
VL 4
IS 8
AR nzaa122
DI 10.1093/cdn/nzaa122
PG 14
WC Nutrition & Dietetics
WE Emerging Sources Citation Index (ESCI)
SC Nutrition & Dietetics
GA OW6TY
UT WOS:000593017800014
PM 32856011
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Moore, BF
   Clark, ML
   Bachand, A
   Reynolds, SJ
   Nelson, TL
   Peel, JL
AF Moore, Brianna F.
   Clark, Maggie L.
   Bachand, Annette
   Reynolds, Stephen J.
   Nelson, Tracy L.
   Peel, Jennifer L.
TI Interactions Between Diet and Exposure to Secondhand Smoke on Glycated
   Hemoglobin Levels Among US Children: Results From NHANES 2007-2012
SO NICOTINE & TOBACCO RESEARCH
LA English
DT Article
ID CORONARY-HEART-DISEASE; OXIDATIVE STRESS; CARDIOVASCULAR-DISEASE;
   METABOLIC SYNDROME; PLASMA-GLUCOSE; RISK; NICOTINE; SUPPLEMENTATION;
   PREVALENCE; COTININE
AB Antioxidant-rich diets may lessen the adverse metabolic responses triggered by exposure to secondhand smoke (SHS), but no studies have investigated these potential interactions.
   To examine the interaction between diet and exposure to SHS on glycated hemoglobin (HbA1c) levels among 2551 children, ages 12-19 years, who participated in the 2007-2012 National Health and Nutrition Examination Survey (NHANES).
   Exposure to SHS was assessed by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), cotinine, and self-report. Weighted linear regression models evaluated the cross-sectional association between exposure to SHS and HbA1c levels. Additive interaction was assessed by introducing product terms (with SHS) of individual nutrients (dietary fiber, eicosapentaenoic acid [EPA], docosahexaenoic acid [DHA], vitamin C, and vitamin E) to separate models.
   Over half of the children had NNAL or cotinine levels above the limit of detection (56% and 71%, respectively). The median HbA1c level was 5.2% (95% confidence interval: 5.17%, 5.23%). The interaction results suggest that the effects of exposure to SHS and certain dietary nutrients (EPA, DHA, vitamin C) on HbA1c levels may not be independent. For example, although there was only a slight difference in adjusted mean HbA1c levels across NNAL categories among children with high EPA intakes, the adjusted mean HbA1c level was 0.09% higher for high NNAL as compared to low NNAL among children with low EPA intakes.
   Further research is needed to inform public health strategies for limiting increases in HbA1c levels among children. Messages may need to focus both on reducing exposure to SHS and improving diets to obtain the maximum benefit.
   Our results suggest that the effects of exposure to SHS and diet on HbA1c levels may not be independent. For example, although there was little effect of exposure to SHS on HbA1c levels among children with high EPA intakes, high exposure to SHS was associated with an increase in HbA1c levels among children with low EPA intakes. Further research is necessary; however, based on these joint effects, strategies for limiting increases in HbA1c levels that focus both on reducing exposure to SHS and improving diets may achieve the largest public health benefits.
C1 [Moore, Brianna F.] CSPH, Dept Epidemiol, Aurora, CO 80045 USA.
   [Clark, Maggie L.; Bachand, Annette; Reynolds, Stephen J.; Peel, Jennifer L.] Colorado State Univ, Dept Environm & Radiol Hlth Sci, Ft Collins, CO 80523 USA.
   [Nelson, Tracy L.] Colorado State Univ, Dept Hlth & Exercise Sci, Ft Collins, CO 80523 USA.
C3 Colorado State University System; Colorado State University Fort
   Collins; Colorado State University System; Colorado State University
   Fort Collins
RP Moore, BF (corresponding author), CSPH, Dept Epidemiol, Aurora, CO 80045 USA.
EM Brianna.F.Moore@ucdenver.edu
RI Nelson, Tracy/ACF-1636-2022; Moore, Brianna/AAZ-1342-2020
OI Clark, Maggie/0000-0002-8613-5736; Moore, Brianna/0000-0002-1084-3349
FU American Heart Association [14PRE18230007]; American Heart Association
   (AHA) [14PRE18230007] Funding Source: American Heart Association (AHA)
FX This project was supported by the American Heart Association (fund
   number 14PRE18230007).
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NR 50
TC 2
Z9 3
U1 0
U2 10
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1462-2203
EI 1469-994X
J9 NICOTINE TOB RES
JI Nicotine Tob. Res.
PD JUL
PY 2017
VL 19
IS 7
BP 845
EP 851
DI 10.1093/ntr/ntw261
PG 7
WC Substance Abuse; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Substance Abuse; Public, Environmental & Occupational Health
GA EZ7UD
UT WOS:000404930300011
PM 27679605
DA 2025-06-11
ER

PT J
AU Verzola, D
   Gandolfo, MT
   Gaetani, G
   Ferraris, A
   Mangerini, R
   Ferrario, F
   Villaggio, B
   Gianiorio, F
   Tosetti, F
   Weiss, U
   Traverso, P
   Mji, M
   Deferrari, G
   Garibotto, G
AF Verzola, Daniela
   Gandolfo, Maria Teresa
   Gaetani, Gianfranco
   Ferraris, Annamaria
   Mangerini, Rosa
   Ferrario, Franco
   Villaggio, Barbara
   Gianiorio, Fabio
   Tosetti, Fanny
   Weiss, Ursula
   Traverso, Paolo
   Mji, Mariano
   Deferrari, Giacomo
   Garibotto, Giacomo
TI Accelerated senescence in the kidneys of patients with type 2 diabetic
   nephropathy
SO AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
LA English
DT Article
DE tubular cells; telomeres; p16(INK4A); senescence-associated
   beta-galactosidase
ID GLUCOSE-INDUCED HYPERTROPHY; CYCLE INHIBITOR P16(INK4A); HUMAN
   FIBROBLASTS; MESANGIAL CELLS; TELOMERE ATTRITION; OXIDATIVE STRESS;
   RENAL INJURY; EXPRESSION; APOPTOSIS; DISEASE
AB Verzola D, Gandolfo MT, Gaetani G, Ferraris AM, Mangerini R, Ferrario F, Villaggio B, Gianiorio F, Tosetti F, Weiss U, Traverso P, Mji M, Deferrari G, Garibotto G. Accelerated senescence in the kidneys of patients with type 2 diabetic nephropathy. Am J Physiol Renal Physiol 295: F1563-F1573, 2008. First published September 3, 2008; doi:10.1152/ajprenal.90302.2008. -We examined the hypothesis that senescence represents a proximate mechanism by which the kidney is damaged in type 2 diabetic nephropathy (DN). As a first step, we studied whether the senescence-associated beta- galactosidase (SA-beta-Gal) and the cell cycle inhibitor p16(INK4A) are induced in renal biopsies from patients with type 2 DN. SA-beta-Gal staining was approximately threefold higher (P < 0.05) than in controls in the tubular compartment of diabetic kidneys and correlated directly with body mass index and blood glucose. P16(INK4A) expression was significantly increased in tubules (P < 0.005) and in podocytes (P = 0.04). Nuclear p16(INK4A) in glomeruli was associated with proteinuria (P < 0.002), while tubular p16(INK4A) was directly associated with body mass index, LDL cholesterol, and HbA1c (P < 0.001-0.05). In a parallel set of experiments, proximal tubule cells passaged under high glucose presented a limited life span and an approximately twofold increase in SA-beta-Gal and p16(INK4A) protein. Mean telomere lengths decreased similar to 20% as an effect of replicative senescence. In addition, mean telomere decreased further by similar to 30% in cells cultivated under high glucose. Our results show that the kidney with type 2 diabetic nephropathy displays an accelerated senescent phenotype in defined renal cell types, mainly tubule cells and, to a lesser extent, podocytes. A similar senescent pattern was observed when proximal tubule cell cultures where incubated under high-glucose media. These changes are associated with shortening tubular telomere length in vitro. These findings indicate that diabetes may boost common pathways involving kidney cell senescence, thus reinforcing the role of the metabolic syndrome on biological aging of tissues.
C1 [Verzola, Daniela; Gandolfo, Maria Teresa; Villaggio, Barbara; Gianiorio, Fabio; Tosetti, Fanny; Weiss, Ursula; Deferrari, Giacomo; Garibotto, Giacomo] Univ Genoa, Azienda Univ Osped San Martino, Dept Internal Med & Cardionephrol, I-16126 Genoa, Italy.
   [Gaetani, Gianfranco; Ferraris, Annamaria; Mangerini, Rosa] Univ Genoa, Dipartimento Oncol Biol & Genet, Genoa, Italy.
   [Gaetani, Gianfranco; Ferraris, Annamaria; Mangerini, Rosa] Ist Nazl Ric Canc, I-16132 Genoa, Italy.
   [Ferrario, Franco] San Carlo Hosp, Renal Immunopathol Ctr, Milan, Italy.
   [Traverso, Paolo] Univ Genoa, Dept Urol, I-16126 Genoa, Italy.
   [Mji, Mariano] Imperia Hosp, Div Nephrol, Imperia, Italy.
C3 University of Genoa; IRCCS AOU San Martino IST; University of Genoa;
   University of Genoa; IRCCS AOU San Martino IST; San Carlo Borromeo
   Hospital; University of Genoa
RP Deferrari, G (corresponding author), Dept Internal Med, Div Nephrol, Viale Benedetto XV,6, I-16132 Genoa, Italy.
EM gari@unige.it
RI Verzola, Daniela/U-2761-2019; Garibotto, Giacomo/AAB-1190-2019
OI GARIBOTTO, GIACOMO/0000-0001-6432-2429; DEFERRARI,
   GIACOMO/0000-0001-8703-2416
FU Ministero dell'Universitae della Ricerca Scientifica e Tecnologica;
   Regione Liguria; AIL Cuneo
FX This study was supported by a grant from the Ministero dell'Universitae
   della Ricerca Scientifica e Tecnologica (FIRB 2001) and from Grants P.
   F. Regione Liguria 2003, AIL Cuneo, and Regione Liguria 2005 n. 1582.
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   KIDNEY INT
NR 37
TC 221
Z9 237
U1 1
U2 32
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 1931-857X
EI 1522-1466
J9 AM J PHYSIOL-RENAL
JI Am. J. Physiol.-Renal Physiol.
PD NOV
PY 2008
VL 295
IS 5
BP F1563
EP F1573
DI 10.1152/ajprenal.90302.2008
PG 11
WC Physiology; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology; Urology & Nephrology
GA 369DP
UT WOS:000260674800035
PM 18768588
DA 2025-06-11
ER

PT J
AU Lu, CYZ
   Zhang, JL
   Zhang, YJ
   Bao, XS
AF Lu, Chuanyingzi
   Zhang, Jingli
   Zhang, Yajing
   Bao, Xiaoshi
TI NR1I2 as a core biological target in chronic venous ulcer tissues
   treated with ultrasound therapy
SO MEDICINE
LA English
DT Article
DE biological target; chronic venous; tissues treated; ultrasound therapy
ID INFLAMMATION; DISEASE
AB Ultrasound therapy is a method of applying ultrasonic energy to the stimulation produced by human body to change the function and tissue state of the body in order to achieve the purpose of treating diseases. Chronic venous ulcer is a common chronic skin ulcer. GSE222503 for ultrasound therapy of chronic venous ulcers was downloaded from gene expression omnibus database, which were used to identify differentially expressed genes. Weighted gene co-expression network analysis, functional enrichment analysis, gene set enrichment analysis, immune infiltration analysis and construction and analysis of protein-protein interaction network were performed. Draw gene expression heatmaps. Comparative toxicogenomics database analysis was performed. Two hundred thirty-five differentially expressed genes were obtained. According to gene ontology analysis, in biological process analysis, they were mainly enriched in positive regulation of cellular biosynthetic process, reproductive cell development, vasculogenesis, vascular morphogenesis, and inflammatory response. In cellular component analysis, they were mainly enriched in leading edge of growing cell, extracellular matrix binding organelle, F-actin capping protein complex. In molecular function analysis, they were mainly concentrated in receptor ligand activity, cytokine receptor binding. In Kyoto encyclopedia of genes and genomes analysis, they were mainly enriched in cytokine-cytokine receptor interaction, PI3K-Akt signaling pathway, HIF-1 signaling pathway, heme biosynthesis. In weighted gene co-expression network analysis, the soft threshold power was set to 9. Thirty modules were generated. PF4, NR1I2, TTC16, H3C12, KLRB1, CYP21A2 identified by 4 algorithms (MCC, EPC, closeness, stress). Heatmap of core gene expression showed that H3C12, KLRB1, PF4, NR1I2 were all underexpressed in samples of ultrasound-treated chronic venous ulcers and overexpressed in samples of untreated chronic venous ulcers. Comparative toxicogenomics database analysis showed that H3C12, KLRB1, PF4, NR1I2 are associated with thrombophlebitis, phlebitis, vascular malformations, metabolic syndrome, ulcers, and inflammation. In samples of chronic venous ulcer tissue treated with ultrasound, NR1I2 shows low expression, while in samples of chronic venous ulcer tissue without ultrasound treatment, it shows high expression. This finding suggests a potential role of NR1I2 in the process of ultrasound therapy for chronic venous ulcers, which may be related to the therapeutic effect of ultrasound therapy on chronic venous ulcers.
C1 [Lu, Chuanyingzi; Zhang, Jingli; Zhang, Yajing; Bao, Xiaoshi] Capital Med Univ, Beijing Rehabil Hosp, Rehabil Ultrason Dept, Beijing 100144, Peoples R China.
C3 Capital Medical University
RP Lu, CYZ (corresponding author), Capital Med Univ, Beijing Rehabil Hosp, Rehabil Ultrason Dept, Beijing 100144, Peoples R China.
EM luchuanyingzi51@163.com; bjzyj322@126.com; bjzyj322@126.com;
   13552095007@139.com
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NR 25
TC 0
Z9 0
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD MAY 10
PY 2024
VL 103
IS 19
AR e38092
DI 10.1097/MD.0000000000038092
PG 11
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA QA3O4
UT WOS:001218122900053
PM 38728468
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Sumbalová, Z
   Kucharská, J
   Rausová, Z
   Gvozdjáková, A
   Szántová, M
   Kura, B
   Mojto, V
   Slezák, J
AF Sumbalova, Zuzana
   Kucharska, Jarmila
   Rausova, Zuzana
   Gvozdjakova, Anna
   Szantova, Maria
   Kura, Branislav
   Mojto, Viliam
   Slezak, Jan
TI The Effect of Adjuvant Therapy with Molecular Hydrogen on Endogenous
   Coenzyme Q10 Levels and Platelet Mitochondrial Bioenergetics
   in Patients with Non-Alcoholic Fatty Liver Disease
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE molecular hydrogen; platelets; mitochondria; oxidative phosphorylation;
   coenzyme Q(10)
ID RICH WATER; PERMEABILIZED FIBERS; LIPID-PEROXIDATION; METABOLIC
   SYNDROME; OXPHOS PROTOCOLS; SMALL BIOPSIES; HUMAN-CELLS; PLASMA;
   STEATOHEPATITIS; ANTIOXIDANT
AB Molecular hydrogen (H-2) has been recognized as a novel medical gas with antioxidant and anti-inflammatory effects. Non-alcoholic fatty liver disease (NAFLD) is a liver pathology with increased fat accumulation in liver tissue caused by factors other than alcohol consumption. Platelet mitochondrial function is considered to reflect systemic mitochondrial health. We studied the effect of adjuvant therapy with hydrogen-rich water (HRW) on coenzyme Q(10) (CoQ(10)) content and platelet mitochondrial bioenergetics in patients with NAFLD. A total of 30 patients with NAFLD and 15 healthy volunteers were included in this clinical trial. A total of 17 patients (H-2 group) drank water three x 330 mL/day with tablets producing HRW (>4 mg/L H-2) for 8 weeks, and 13 patients (P group) drank water with placebo tablets producing CO2. The concentration of CoQ(10-TOTAL) was determined by the HPLC method, the parameter of oxidative stress, thiobarbituric acid reactive substances (TBARS), by the spectrophotometric method, and mitochondrial bioenergetics in platelets isolated from whole blood by high-resolution respirometry. The patients with NAFLD had lower concentrations of CoQ(10-TOTAL) in the blood, plasma, and platelets vs. the control group. Mitochondrial CI-linked LEAK respiration was higher, and CI-linked oxidative phosphorylation (OXPHOS) and CII-linked electron transfer (ET) capacities were lower vs. the control group. Plasma TBARS concentrations were higher in the H-2 group. After 8 weeks of adjuvant therapy with HRW, the concentration of CoQ(10) in platelets increased, plasma TBARS decreased, and the efficiency of OXPHOS improved, while in the P group, the changes were non-significant. Long-term supplementation with HRW could be a promising strategy for the acceleration of health recovery in patients with NAFLD. The application of H-2 appears to be a new treatment strategy for targeted therapy of mitochondrial disorders. Additional and longer-term studies are needed to confirm and elucidate the exact mechanisms of the mitochondria-targeted effects of H-2 therapy in patients with NAFLD.
C1 [Sumbalova, Zuzana; Kucharska, Jarmila; Rausova, Zuzana; Gvozdjakova, Anna] Comenius Univ, Fac Med, Dept Internal Med 3, Pharmacobiochem Lab, Bratislava 81108, Slovakia.
   [Szantova, Maria; Mojto, Viliam] Comenius Univ, Fac Med, Dept Internal Med 3, Bratislava 81372, Slovakia.
   [Kura, Branislav; Slezak, Jan] Slovak Acad Sci, Inst Heart Res, Ctr Expt Med, Bratislava 84104, Slovakia.
C3 Comenius University Bratislava; Comenius University Bratislava; Slovak
   Academy of Sciences; Institute for Heart Research, SAS; Centre of
   Experimental Medicine, SAS
RP Sumbalová, Z (corresponding author), Comenius Univ, Fac Med, Dept Internal Med 3, Pharmacobiochem Lab, Bratislava 81108, Slovakia.
EM zuzana.sumbalova@fmed.uniba.sk; jarmila.kucharska@fmed.uniba.sk;
   zuzana.rausova@fmed.uniba.sk; anna.gvozdjakova@fmed.uniba.sk;
   maria.szantova@kr.unb.sk; branislav.kura@savba.sk;
   viliam.mojto@kr.unb.sk; jan.slezak@savba.sk
OI Kura, Branislav/0000-0001-6743-491X; Sumbalova,
   Zuzana/0000-0001-9454-6255
FU Slovak Research and Development Agency [APVV-19-0317]; Scientific Grant
   Agency of the Ministry of Education, Science, Research and Sport of the
   Slovak Republic; Slovak Academy of Sciences (VEGA) [2/0063/18,
   2/0092/222, 2/0148/22, 2018/7838:1-26C0]; Grant of Ministry of Health of
   Slovak Republic [2019/4-CEMSAV-1]; HRW Natural Health Products Inc;
   Operational Program Integrated Infrastructure for the project: Research
   and development in medical sciences-the way to personalized treatment of
   serious neurological, cardiovascular, and cancer diseases [ITMS
   313011T431]; European Regional Development Fund
FX This research was funded by the Slovak Research and Development Agency
   (APVV-19-0317); the Scientific Grant Agency of the Ministry of
   Education, Science, Research and Sport of the Slovak Republic and the
   Slovak Academy of Sciences (VEGA) 2/0063/18, 2/0092/222, 2/0148/22,
   grant 2018/7838:1-26C0; the Grant of Ministry of Health of Slovak
   Republic: 2019/4-CEMSAV-1; and by the HRW Natural Health Products Inc.
   This paper was financially supported by the Operational Program
   Integrated Infrastructure for the project: Research and development in
   medical sciences-the way to personalized treatment of serious
   neurological, cardiovascular, and cancer diseases (ITMS 313011T431),
   co-financed from the resources of the European Regional Development
   Fund. The funders had no role in randomization, data collection,
   interpretation, manuscript writing, or the decision to publish.
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NR 61
TC 12
Z9 12
U1 1
U2 9
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD AUG
PY 2023
VL 24
IS 15
AR 12477
DI 10.3390/ijms241512477
PG 16
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA O8MC8
UT WOS:001046287000001
PM 37569850
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Karamali, M
   Kashanian, M
   Alaeinasab, S
   Asemi, Z
AF Karamali, M.
   Kashanian, M.
   Alaeinasab, S.
   Asemi, Z.
TI The effect of dietary soy intake on weight loss, glycaemic control,
   lipid profiles and biomarkers of inflammation and oxidative stress in
   women with polycystic ovary syndrome: a randomised clinical trial
SO JOURNAL OF HUMAN NUTRITION AND DIETETICS
LA English
DT Article
DE soy diet; weight loss; metabolic status; polycystic ovary syndrome
ID POSTMENOPAUSAL WOMEN; PROTEIN-INTAKE; METABOLIC SYNDROME;
   GENE-EXPRESSION; SERUM-LIPIDS; GENISTEIN; METAANALYSIS; CHOLESTEROL;
   ISOFLAVONES; OVERWEIGHT
AB BackgroundThe present study aimed to evaluate the effects of dietary soy intake on weight loss and metabolic status of patients with polycystic ovary syndrome (PCOS).
   MethodsA randomised clinical trial was conducted among 60 women with PCOS. Participants were randomly assigned into two groups to receive either a test diet (n=30) or a control diet (n=30) for 8weeks. Participants in the test group consumed a diet containing 0.8g proteinkg(-1) body weight (35% animal proteins, 35% soy protein and 30% vegetable proteins) and participants in the control group consumed a similar diet containing 70% animal proteins and 30% vegetable proteins.
   ResultsAdherence to the test diet, compared with the control diet, resulted in significant decreases [mean (SD)] in body mass index (BMI) [-0.3(0.6) versus +0.1(0.5)kgm(-2), P=0.02], fasting plasma glucose [-0.2(0.5) versus +0.1(0.3)mmolL(-1), P=0.01], total testosterone [-0.3(0.7) versus +0.3(0.3)mmolL(-1), P<0.001], insulin [-15.0(18.0) versus +4.8 (18.6)pmolL(-1), P<0.001] and insulin resistance [-0.6(0.6) versus +0.2(0.7), P<0.001], as well as a significant increase in quantitative insulin sensitivity check index [+0.01(0.01) versus -0.002(0.02), P=0.01]. In addition, significant decreases in triglycerides [-0.1(0.4) versus +0.2(0.3)mmolL(-1), P=0.01] and malondialdehyde (MDA) [-1.2(1.0) versus +0.2(1.2)molL(-1), P<0.001] and significant increases in nitric oxide (NO) [+13.6(14.1) versus +0.9(24.3)molL(-1), P=0.01] and glutathione (GSH) [+170.1(175.5) versus +24.2(168.7)molL(-1), P=0.002] were seen in the test group compared to the control.
   ConclusionsAdherence to test diet among subjects with PCOS significantly decreased BMI, glycaemic control, total testosterone, triglycerides and MDA, and significantly increased NO and GSH compared to the control diet.
C1 [Karamali, M.; Kashanian, M.] Iran Univ Med Sci, Sch Med, Dept Gynecol & Obstet, Tehran, Iran.
   [Alaeinasab, S.] Imam Sajad Hosp, Tehran, Iran.
   [Asemi, Z.] Kashan Univ Med Sci, Res Ctr Biochem & Nutr Metab Dis, Kashan, Iran.
C3 Iran University of Medical Sciences
RP Asemi, Z (corresponding author), Kashan Univ Med Sci, Res Ctr Biochem & Nutr Metab Dis, Kashan, Iran.
EM asemi_r@yahoo.com
RI asemi, zatollah/J-2677-2018; Asemi, Zatollah/G-7393-2017
OI Asemi, Zatollah/0000-0001-5265-4792
FU IUMS
FX The present study was funded by a grant from the Vice-chancellor for
   Research, IUMS, and Iran. We thank the staff of Akbarabadi Clinic
   (Tehran, Iran) for their assistance with this project.
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NR 57
TC 34
Z9 36
U1 0
U2 29
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0952-3871
EI 1365-277X
J9 J HUM NUTR DIET
JI J. Hum. Nutr. Diet.
PD AUG
PY 2018
VL 31
IS 4
BP 533
EP 543
DI 10.1111/jhn.12545
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA GN1DA
UT WOS:000438723800010
PM 29468748
DA 2025-06-11
ER

PT J
AU Köninger, A
   Mathan, A
   Mach, P
   Frank, M
   Schmidt, B
   Schleussner, E
   Kimmig, R
   Gellhaus, A
   Dieplinger, H
AF Koeninger, Angela
   Mathan, Annette
   Mach, Pawel
   Frank, Mirjam
   Schmidt, Boerge
   Schleussner, Ekkehard
   Kimmig, Rainer
   Gellhaus, Alexandra
   Dieplinger, Hans
TI Is Afamin a novel biomarker for gestational diabetes mellitus? A pilot
   study
SO REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
LA English
DT Article
DE Afamin; Pregnancy; Insulin resistance; Gestational diabetes mellitus;
   Oral glucose tolerance test
ID INSULIN-RESISTANCE; CARBOHYDRATE-METABOLISM; PREGNANCY; GLUCOSE; WOMEN;
   HYPERGLYCEMIA; PREVALENCE; DIAGNOSIS; ALPHA; INFLAMMATION
AB Background: In search of potential early biomarkers for timely prediction of gestational diabetes mellitus (GDM), we focused on afamin, a vitamin E-binding protein in human plasma.. Afamin plays a role in anti-apoptotic cellular processes related to oxidative stress and is associated with insulin resistance and other features of metabolic syndrome. During uncomplicated pregnancy its serum concentrations increase linearly. The aim of this study was to investigate the suitability of afamin as early marker for predicting GDM.
   Methods: In a first-trimester cohort from a prospective observational study of adverse pregnancy outcomes we secondarily analyzed afamin concentrations in 59 patients diagnosed with GDM and 51 controls. Additionally, afamin concentrations were cross-sectionally examined in a mid-trimester cohort of 105 women and compared with results from a simultaneously performed oral glucose tolerance test (OGTT). Subgroup analysis comparing patients treated with either insulin (iGDM) or dietary intervention (dGDM) was performed in both cohorts. Patients were recruited at the University Hospital Essen, Germany, between 2003 and 2016.
   Results: Results were adjusted for body-mass-index (BMI) and gestational age. First and mid-trimester cohorts yielded significantly elevated afamin concentrations in patients with pathological OGTT compared to patients without GDM (first trimester cohort: mean, 113.4 mg/l; 95% CI, 106.4-120.5 mg/l and 87.2 mg/l; 95% CI, 79.7-94. 7 mg/l; mid-trimester cohort: mean, 182.9 mg/l; 95% CI, 169.6-196.2 mg/l and 157.3 mg/l; 95% CI, 149.1-165.4 mg/l, respectively). In the first-trimester cohort, patients developing iGDM later in pregnancy presented with significantly higher afamin concentrations compared to patients developing dGDM and compared to patients without GDM. In the mid-trimester cohort, mean concentrations of afamin differed significantly between patients with dGDM compared to controls and between patients with iGDM and controls. Patients with iGDM showed only slightly higher afamin levels compared to patients with dGDM.
   Conclusion: Afamin may serve as a new early biomarker for pathological glucose metabolism during pregnancy. Further research is needed to determine afamin's concentrations during pregnancy, its predictive value for early detection of pregnancies at high risk to develop GDM and its diagnostic role during the second trimester.
C1 [Koeninger, Angela; Mathan, Annette; Mach, Pawel; Kimmig, Rainer; Gellhaus, Alexandra] Univ Duisburg Essen, Dept Gynecol & Obstet, Hufelandstr 55, D-45122 Essen, Germany.
   [Mathan, Annette] Klinikum Wurzburg Mitte, Dept Gynecol & Obstet, Salvatorstr 7, D-97074 Wurzburg, Germany.
   [Frank, Mirjam; Schmidt, Boerge] Univ Duisburg Essen, Inst Med Informat Biometry & Epidemiol IMIBE, Hufelandstr 55, D-45122 Essen, Germany.
   [Schleussner, Ekkehard] Jena Univ Hosp, Dept Obstet, Klinikum 1, D-07747 Jena, Germany.
   [Dieplinger, Hans] Med Univ Innsbruck, Div Genet Epidemiol, Dept Med Genet Mol & Clin Pharmacol, Schopfstr 41, A-6020 Innsbruck, Austria.
   [Dieplinger, Hans] Vitateq Biotechnol GmbH, A-6020 Innsbruck, Austria.
C3 University of Duisburg Essen; University of Duisburg Essen; Friedrich
   Schiller University of Jena; Medical University of Innsbruck
RP Dieplinger, H (corresponding author), Med Univ Innsbruck, Div Genet Epidemiol, Dept Med Genet Mol & Clin Pharmacol, Schopfstr 41, A-6020 Innsbruck, Austria.; Dieplinger, H (corresponding author), Vitateq Biotechnol GmbH, A-6020 Innsbruck, Austria.
EM hans.dieplinger@i-med.ac.at
RI Köninger, Angela/I-1971-2016
FU University of Duisburg-Essen; Austrian Research Fund [P19969-B11];
   Austrian Science Fund (FWF) [P19969] Funding Source: Austrian Science
   Fund (FWF)
FX Provided by the University of Duisburg-Essen to A.K. and the Austrian
   Research Fund (P19969-B11) to H.D.
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NR 39
TC 35
Z9 36
U1 0
U2 17
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1477-7827
J9 REPROD BIOL ENDOCRIN
JI Reprod. Biol. Endocrinol.
PD MAR 27
PY 2018
VL 16
AR 30
DI 10.1186/s12958-018-0338-x
PG 11
WC Endocrinology & Metabolism; Reproductive Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Reproductive Biology
GA GB2WR
UT WOS:000428917100004
PM 29587878
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Freire, TO
   Boulhosa, RSSB
   Oliveira, LPM
   de Jesus, RP
   Cavalcante, LN
   Lemaire, DC
   Toralles, MBP
   Lyra, LGC
   Lyra, AC
AF Freire, T. O.
   Boulhosa, R. S. S. B.
   Oliveira, L. P. M.
   de Jesus, R. P.
   Cavalcante, L. N.
   Lemaire, D. C.
   Toralles, M. B. P.
   Lyra, L. G. C.
   Lyra, A. C.
TI n-3 polyunsaturated fatty acid supplementation reduces insulin
   resistance in hepatitis C virus infected patients: a randomised
   controlled trial
SO JOURNAL OF HUMAN NUTRITION AND DIETETICS
LA English
DT Article
DE chronic hepatitis C; inflammation; insulin resistance; n-3 PUFA
   supplementation; nutrition
ID LIVER-DISEASE; METABOLIC SYNDROME; OXIDATIVE STRESS; LIPID-PEROXIDATION;
   DIABETES-MELLITUS; MOUSE MODEL; STEATOSIS; ACTIVATION; PROTEIN; RISK
AB BackgroundInsulin resistance promotes liver disease progression and may be associated with a lower response rate in treated hepatitis C virus (HCV) infected patients. n-3 polyunsaturated fatty acid (PUFA) supplementation may reduce insulin resistance.
   The present study aimed to evaluate the effect of n-3 PUFA supplementation on insulin resistance in these patients.
   MethodsIn a randomised, double-blind clinical trial, 154 patients were screened. After applying inclusion criteria, 52 patients [homeostasis model assessment index of insulin resistance (HOMA-IR2.5)] were randomly divided into two groups: n-3 PUFA (n=25/6000mgday(-1) of fish oil) or control (n=27/6000mgday(-1) of soybean oil). Both groups were supplemented for 12weeks and underwent monthly nutritional consultation. Biochemical tests were performed at baseline and after intervention. Statistical analysis was performed using the Wilcoxon Mann-Whitney test for comparisons and the Wilcoxon test for paired data. Statistical package r, version 3.02 (The R Project for Statistical Computing) was used and P<0.05 (two-tailed) was considered statistically significant.
   ResultsComparisons between groups showed that n-3 PUFA supplementation was more effective than the control for reducing HOMA-IR (P=0.015) and serum insulin (P=0.016). The n-3 PUFA group not only showed a significant reduction in HOMA-IR 3.8 (3.2-5.0) versus 2.4 (1.8-3.3) (P=0.002); serum insulin 17.1 (13.8-20.6)IUmL(-1) versus 10.9 (8.6-14.6)IUmL(-1) (P=0.001); and glycated haemoglobin 5.4% (5.0-5.7%) versus 5.1% (4.8-5.6%) (P=0.011), but also presented an increase in interleukin-1 97.5 (0.0-199.8)pgmL(-1) versus 192.4 (102.2-266.8)pgmL(-1) (P=0.003) and tumour necrosis factor 121.2 (0.0-171.3)pgmL(-1) versus 185.7 (98.0-246.9) pgmL(-1) (P=0.003).
   Conclusionsn-3 PUFA supplementation reduces insulin resistance in genotype 1 HCV infected patients.
C1 [Freire, T. O.; Lyra, L. G. C.; Lyra, A. C.] Univ Fed Bahia, Postgrad Course Med & Hlth, BR-40110150 Salvador, BA, Brazil.
   [Freire, T. O.; Boulhosa, R. S. S. B.; Oliveira, L. P. M.; de Jesus, R. P.] Univ Fed Bahia, Dept Nutr Sci, BR-40110150 Salvador, BA, Brazil.
   [Cavalcante, L. N.; Lyra, A. C.] Univ Fed Bahia, Dept Med, Div Gastroenterol & Hepatol, BR-40110150 Salvador, BA, Brazil.
   [Lemaire, D. C.] Univ Fed Bahia, Hlth Sci Inst, Immunol Lab, BR-40110150 Salvador, BA, Brazil.
   [Toralles, M. B. P.] Univ Fed Bahia, Dept Pediat, BR-40110150 Salvador, BA, Brazil.
   [Lyra, L. G. C.; Lyra, A. C.] Hosp Sao Rafael Bahia, Gastrohepatol Unit, Salvador, BA, Brazil.
C3 Universidade Federal da Bahia; Universidade Federal da Bahia;
   Universidade Federal da Bahia; Universidade Federal da Bahia;
   Universidade Federal da Bahia
RP Freire, TO (corresponding author), Univ Fed Bahia, Dept Ciencia Nutr, Escola Nutr, Ave Araujo Pinho,32-Canela, BR-40110150 Salvador, BA, Brazil.
EM thiagonofre@yahoo.com.br
RI Boulhosa, Ramona/KHX-2630-2024; da Silva martins, Maria/AAH-3160-2021
OI , Lucivalda/0000-0003-4822-5930; Boulhosa, Ramona/0000-0001-7590-5793
FU Foundation for Research Support of the State of Bahia (FAPESB) [PPSUS
   20/20]
FX Financial support for the present study was provided by the Foundation
   for Research Support of the State of Bahia (FAPESB), edict PPSUS 20/20.
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NR 61
TC 6
Z9 6
U1 1
U2 15
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0952-3871
EI 1365-277X
J9 J HUM NUTR DIET
JI J. Hum. Nutr. Diet.
PD JUN
PY 2016
VL 29
IS 3
BP 345
EP 353
DI 10.1111/jhn.12327
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA DJ3VS
UT WOS:000374135400008
PM 26216648
OA Bronze
DA 2025-06-11
ER

PT J
AU Chen, JW
   Wu, SY
   Pan, WH
AF Chen, JW
   Wu, SY
   Pan, WH
TI Clinical characteristics of young-onset hypertension-implications for
   different genders
SO INTERNATIONAL JOURNAL OF CARDIOLOGY
LA English
DT Article
DE blood pressure; body mass index; triglyceride; young-onset hypertension
ID CARDIOVASCULAR RISK-FACTORS; SODIUM-LITHIUM COUNTERTRANSPORT;
   BLOOD-PRESSURE; MENTAL STRESS; INSULIN; LIPIDS; TRIGLYCERIDES;
   ASSOCIATION; PREDICTORS; HEALTH
AB Background: Hypertension may develop early, before the age of 40 years, in both genders, so-called young-onset hypertension. The clinical characteristics of young-onset hypertension have not been well defined. Methods: The personal history and clinical characteristics were evaluated in a series of patients with young-onset hypertension. With the individual-matching, case-controlled design, patients were initially matched for age, gender and residence with the first control (C1) group in either 2:1 or 1:1 fashion. They were then additionally matched for body mass index (BMI) with the second control (C2) group in 1: 1 fashion. To elucidate the possible difference between genders, all the comparisons were conducted in males and females separately. Results: A total of 82 consecutive patients, 56 males and 26 females, with young-onset hypertension were included. Compared with the 148 subjects in C I group, hypertensive patients were relatively highly educated and had less alcohol drinking in either gender. BMI (25.10 +/- 0.49 vs. 22.34 +/- 0.31 kg/m(2), P < 0.001) and serum triglyceride level (153.35 +/- 10.71 vs. 98.76 +/- 5.12 mg/dl, P < 0.001) were significantly increased in male patients, while serum uric acid (5.74 +/- 0.34 vs. 4.78 +/- 0.17 mg/dl, P = 0.006) and triglyceride level (121.39 +/- 12.71 vs. 76.58 +/- 4.88 mg/dl, P = 0.002) were increased in female ones. Compared to that in C2 group, serum triglyceride level was still increased in patients of either gender. Interestingly, serum cholesterol level in female patients was lower than that in either C I or C2 group. Further, serum triglyceride level was significantly correlated to BMI, serum cholesterol and glucose level in male patients but only to serum uric acid level in female ones. Conclusions: Clinical characteristics of young-onset hypertension were unique and different by gender. Though consistently increased in patients of either gender, serum triglyceride level was correlated to BMI, serum cholesterol and glucose level only in males, suggesting the gender-specific presence of metabolic syndrome in young-onset hypertension. (C) 2003 Elsevier Ireland Ltd. All rights reserved.
C1 Taipei Vet Gen Hosp, Dept Med, Div Cardiol, Taipei 11217, Taiwan.
   Natl Yang Ming Univ, Sch Med, Cardiovasc Res Ctr, Taipei 11217, Taiwan.
   Acad Sinica, Inst Biomed Sci, Taipei 115, Taiwan.
C3 Taipei Veterans General Hospital; National Yang Ming Chiao Tung
   University; Academia Sinica - Taiwan
RP Taipei Vet Gen Hosp, Dept Med, Div Cardiol, 201 Shih Pai Rd,Sect 2, Taipei 11217, Taiwan.
EM jwchen@vghtpe.gov.tw
RI Chen, Jiunn-Wei/AAI-9509-2021; Pan, Wen-Harn/F-9972-2010
CR [Anonymous], ARCH INTERN MED
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NR 38
TC 12
Z9 13
U1 0
U2 5
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0167-5273
EI 1874-1754
J9 INT J CARDIOL
JI Int. J. Cardiol.
PD JUL
PY 2004
VL 96
IS 1
BP 65
EP 71
DI 10.1016/j.ijcard.2003.07.010
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 838UG
UT WOS:000222738200010
PM 15203263
DA 2025-06-11
ER

PT J
AU Veras, K
   Lucena, CF
   Goedcke, J
   Evangelista, FS
   Carpinelli, A
   Carvalho, CRD
AF Veras, Katherine
   Lucena, Camila Ferraz
   Goedcke, Julia
   Evangelista, Fabiana S.
   Carpinelli, Angelo
   Carvalho, Carla Roberta de Oliveira
TI Moderate Exercise Training Combined With a High-Fat and Sucrose Diet
   Protects Pancreatic Islet Function in Male C57BL/6J Mice
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Article
DE high fat and sucrose diet; aerobic exercise training; obesity;
   pancreatic islets; glucose tolerance; insulin sensitivity
ID BETA-CELL FUNCTION; HOMEOSTASIS MODEL ASSESSMENT; TERM HIGH-FAT;
   INSULIN-RESISTANCE; UNCOUPLING PROTEIN-2; METABOLIC SYNDROME; OXIDATIVE
   STRESS; BODY-WEIGHT; GLUCOSE; RAT
AB Obesity is mainly caused by excess energy intake and physical inactivity, and the number of overweight/obese individuals has been steadily increasing for decades. Previous studies showed that rodents fed westernized diets exhibit endocrine pancreas deterioration and a range of metabolic disorders. This study evaluated the effects of moderated aerobic treadmill exercise training on pancreatic islet cell viability and function in mice consuming a high-fat and sucrose diet. In the present study, 60-day-old male C57BL/6J mice were divided into four groups: control (C), fed a standard diet AIN-93M (3.83 kcal/g; 70% carbohydrate (cornstarch and dextrinized starch were chosen as the major source of carbohydrate for the AIN-93 diet. In addition, a small amount of sucrose), 20% protein (casein), and 10% fat (soybean) with no training (i.e., sedentary); C + training (CTR, fed the standard diet with eight weeks of exercise; high-fat diet + sucrose (HFDS), fed a high fat and sucrose diet (5.2 kcal/g; 20% carbohydrate (cornstarch and dextrinized starch were chosen as the major source of carbohydrate), 20% protein (casein), 60% fat (Lard was chosen as the major source of fat and a small amount of soybean) + 20% sucrose diluted in drinking water with no training; and HFDS + training (HFDSTR). After eight weeks, the HFDS mice displayed increased body weight (P<0.001) and epididymal, inguinal and retroperitoneal adipose tissue mass (P<0.01). These mice also presented insulin resistance (P<0.01), glucose intolerance (P<0.001), impaired glucose-stimulated insulin secretion (GSIS) and were less responsive to the physiological net ROS production induced by glucose stimulus. The HFDS group's pancreatic islet cells were 38% less viable and 59% more apoptotic than those from the C group (P<0.05). The HFDSTR improved glucose tolerance, body mass, insulin sensitivity and GSIS (P<0.05). Furthermore, HFDSTR mice had 53% more viable isolated pancreatic islets cells and 29% fewer apoptotic cells than the HFDS group (P<0.01). Thus, exercise training may slow down and/or prevent adverse metabolic effects associated with consuming a westernized diet.
C1 [Veras, Katherine; Lucena, Camila Ferraz; Carpinelli, Angelo; Carvalho, Carla Roberta de Oliveira] Univ Sao Paulo, Inst Biomed Sci, Dept Physiol & Biophys, Sao Paulo, Brazil.
   [Goedcke, Julia] South African Med Res Council, Noncommunicable Dis Res Unit, Cape Town, South Africa.
   [Evangelista, Fabiana S.] Univ Sao Paulo, Sch Arts Sci & Humanities, Sao Paulo, Brazil.
   [Veras, Katherine] Dublin City Univ, Sch Hlth & HumanPerformance, Dublin, Ireland.
C3 Universidade de Sao Paulo; Institute Biomed Science, University Sao
   Paulo; South African Medical Research Council; Universidade de Sao
   Paulo; Dublin City University
RP Veras, K (corresponding author), Univ Sao Paulo, Inst Biomed Sci, Dept Physiol & Biophys, Sao Paulo, Brazil.
RI VERAS, KATHERINE/HTS-8114-2023; Carpinelli, Angelo/G-8566-2011;
   Evangelista, Fabiana/A-5298-2013; Carvalho, Carla/H-6476-2018
OI Evangelista, Fabiana/0000-0002-8103-6923; Carvalho,
   Carla/0000-0001-5824-8656
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NR 61
TC 1
Z9 1
U1 0
U2 4
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD MAY 20
PY 2022
VL 13
AR 881236
DI 10.3389/fendo.2022.881236
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 1V4VV
UT WOS:000806090200001
PM 35669687
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Goracy, I
   Rebacz-Maron, E
   Korbecki, J
   Goracy, J
AF Goracy, Iwona
   Rebacz-Maron, Ewa
   Korbecki, Jan
   Goracy, Jaroslaw
TI Concentrations of Mg, Ca, Fe, Cu, Zn, P and anthropometric and
   biochemical parameters in adults with chronic heart failure
SO PEERJ
LA English
DT Article
DE Anthropometry; Chronic heart failure; Biochemical parameters;
   Cardiology; Blood serum; Overweight; Diabetes; Hypertension; High
   triglycerides; NYHA
ID 2016 ESC GUIDELINES; IRON-DEFICIENCY; CARDIOVASCULAR-DISEASE; SERUM
   COPPER; DIASTOLIC DYSFUNCTION; SIGNAL-TRANSDUCTION; METABOLIC SYNDROME;
   DIETARY MAGNESIUM; OXIDATIVE STRESS; TRACE-ELEMENTS
AB Background: The study investigated the relationship between the concentrations of Mg, Ca, Fe, Cu, Zn, P and anthropometric and biochemical parameters in the blood serum of patients with heart failure (HF) and the potential influence on the development and progression of HF.
   Material & methods: The study included 214 patients (155 men and 59 women), aged 40-87 years, presenting symptoms or signs typical of HF (according to the NYHA functional classification). Serum concentrations were determined for Mg, Ca, Fe, Cu, Zn, P, C-reactive protein (CRP), creatinine, urea, triglyceride levels (TG), total cholesterol (CH), high density protein (HDL), low density protein (LDL). The levels of macro-and microminerals were analysed using inductively coupled serum optical emission spectrometry (ICP-OES).
   Results: Our study confirmed the role of known risk factors in the development of heart failure, including: overweight, diabetes, hypertension, high triglycerides (TG), high total cholesterol (CH), high levels of low density protein (LDL) and reduced levels of high density protein (HDL), high CRP, high creatinine. Moreover, deficient serum concentrations of Mg (47% of the studied men and 54% of the women) and Cu (in 44% of men and more than 30% of women) were observed, as well as subnormal serum Fe (2% of women) and Zn (1% of men). Elevated serum Ca was found in 50% of men and 49% of women. In 44% of the studied men and 52% of the studied women, P levels in serum were also above-average. The study revealed a significant positive correlation between serum levels of Ca and Mg, and also Ca and Cu in women. In men, serum Cu was positively correlated with Mg and Ca concentrations. In patients from group 1 (NYHA I-II), Mg content was positively correlated with Ca and Cu. In this patient group, Ca was also positively associated with Cu content in serum. In group 2 (NYHA III-IV), serum Mg concentration was significantly positively correlated with that of Cu and Ca.
   Conclusions: Changes in the serum concentrations of macro-and microminerals may significantly affect the severity of HF in Polish patients.
C1 [Goracy, Iwona] Pomeranian Med Univ, Dept Clin & Mol Biochem, Szczecin, Poland.
   [Rebacz-Maron, Ewa] Univ Szczecin, Inst Biol, Dept Ecol & Anthropol, Szczecin, Poland.
   [Korbecki, Jan] Wroclaw Med Univ, Dept Histol & Embryol, Dept Human Morphol & Embryol, Wroclaw, Poland.
   [Goracy, Jaroslaw] Pomeranian Med Univ, Clin Cardiol, Szczecin, Poland.
C3 Pomeranian Medical University; University of Szczecin; Wroclaw Medical
   University; Pomeranian Medical University
RP Rebacz-Maron, E (corresponding author), Univ Szczecin, Inst Biol, Dept Ecol & Anthropol, Szczecin, Poland.
EM ewa.rebacz-maron@usz.edu.pl
RI Rębacz-Maron, Ewa/D-3526-2016
FU Pomeranian Medical University, Szczecin, Poland
FX The study was financed by internal funding of the Pomeranian Medical
   University, Szczecin, Poland. No other external funding was received.
   The funders had no role in study design, data collection and analysis,
   decision to publish, or preparation of the manuscript.
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NR 95
TC 6
Z9 7
U1 1
U2 10
PU PEERJ INC
PI LONDON
PA 341-345 OLD ST, THIRD FLR, LONDON, EC1V 9LL, ENGLAND
SN 2167-8359
J9 PEERJ
JI PeerJ
PD NOV 1
PY 2021
VL 9
AR e12207
DI 10.7717/peerj.12207
PG 33
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA WW7NC
UT WOS:000718097400002
PM 34760349
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU de Souza, DC
   Matos, VAF
   dos Santos, VOA
   Medeiros, IF
   Marinho, CSR
   Nascimento, PRP
   Dorneles, GP
   Peres, A
   Müller, CH
   Krause, M
   Costa, EC
   Fayh, APT
AF de Souza, Daniel C.
   Matos, Victor A. F.
   dos Santos, Victor O. A.
   Medeiros, Italo F.
   Marinho, Cristiane S. R.
   Nascimento, Paulo R. P.
   Dorneles, Gilson P.
   Peres, Alessandra
   Mueller, Carlos H.
   Krause, Mauricio
   Costa, Eduardo C.
   Fayh, Ana P. T.
TI Effects of High-Intensity Interval and Moderate-Intensity Continuous
   Exercise on Inflammatory, Leptin, IgA, and Lipid Peroxidation Responses
   in Obese Males
SO FRONTIERS IN PHYSIOLOGY
LA English
DT Article
DE obesity; aerobic exercise; high-intensity interval training; cytokines;
   immunoglobulin-A; lipoperoxidation
ID ADIPOSE-TISSUE; METABOLIC SYNDROME; PHYSICAL-ACTIVITY; OXIDATIVE STRESS;
   T-CELLS; ADULTS; OVERWEIGHT; INFECTION; EXERTION; CRITERIA
AB Purpose: To compare the effects of a single high-intensity interval exercise session (HIIE) with a moderate-intensity continuous exercise session (MICE) on the inflammatory profile, IgA levels, and lipid peroxidation in sedentary obese males.
   Methods: Ten sedentary obese men (age 28.5 +/- 2.7 years; BMI 35.9 +/- 4.9 kg/m(2); body fat 40.6 +/- 2.0%) performed three experimental sessions, on separate days with 1 week wash-out period between interventions, according to a randomized order: (1) HIIE: 10 x 60 s at 90% of the HRmax alternated by 60 s of active recovery; (2) MICE: 20 min at 70% of the HRmax; (3) Rest-control. Blood and saliva samples were collected before, immediately after and 60 min after the end of each session in order to analyse serum levels of cytokines, IgA, and lipoperoxidation markers.
   Results: Leptin levels decreased immediately after HIIE (P = 0.033) and was different from the MICE (P = 0.025). IFN-gamma levels were reduced immediately after (P = 0.032) and 60 min after HIIE (P = 0.003) compared to baseline, and it also increased IL-4 levels immediately after exercise (P = 0.007) compared to resting values. MICE promoted an increase in IFN-gamma levels immediately after exercise (P = 0.025) and 60 min after exercise (P = 0.004) in relation to baseline. Both exercise conditions increased IL-6 levels up to 60 min after exercise (P < 0.05). The IFN-gamma/IL-4 ratio decreased immediately after (P = 0.002) and 60 min after HIIE (P = 0.005) in relation to pre-exercise. No changes were found for IgA-S and TBARS for any of the conditions.
   Conclusion: A single HIIE session is able to decrease IFN-gamma/IL-4 ratio, indicating an anti-inflammatory response, without alterations in the function of the mucosal immune system and lipoperoxidation. On the other hand, a brief session of MICE induced changes in the pattern of cytokines associated with increased cellular immune function.
C1 [de Souza, Daniel C.; Matos, Victor A. F.; dos Santos, Victor O. A.; Costa, Eduardo C.; Fayh, Ana P. T.] Univ Fed Rio Grande do Norte, Hlth Sci Ctr, Postgrad Program Phys Educ, Natal, RN, Brazil.
   [Medeiros, Italo F.; Fayh, Ana P. T.] Univ Fed Rio Grande do Norte, Hlth Sci Ctr, Dept Nutr, Natal, RN, Brazil.
   [Marinho, Cristiane S. R.] Univ Fed Rio Grande do Norte, Hlth Sci Coll Trairi, Natal, RN, Brazil.
   [Nascimento, Paulo R. P.] Univ Fed Rio Grande do Norte, Trop Med Inst, Natal, RN, Brazil.
   [Dorneles, Gilson P.; Peres, Alessandra] Fed Univ Hlth Sci Porto Alegre, Lab Cellular & Mol Immunol, Porto Alegre, RS, Brazil.
   [Peres, Alessandra] Methodist Univ, Ctr IPA, Res Ctr, Porto Alegre, RS, Brazil.
   [Mueller, Carlos H.] Univ Fed Rio Grande do Sul, Inst Basic Hlth Sci, Dept Physiol, Lab Pesquisa Inflamacao Metab & Exercicio, Porto Alegre, RS, Brazil.
   [Krause, Mauricio] Univ Fed Rio Grande do Sul, Inst Basic Hlth Sci, Dept Physiol, Lab Inflammat Metab & Exercise Res,Lab Cellular P, Porto Alegre, RS, Brazil.
C3 Universidade Federal do Rio Grande do Norte; Universidade Federal do Rio
   Grande do Norte; Universidade Federal do Rio Grande do Norte;
   Universidade Federal do Rio Grande do Norte; Universidade Federal do Rio
   Grande do Sul; Universidade Federal do Rio Grande do Sul
RP Fayh, APT (corresponding author), Univ Fed Rio Grande do Norte, Hlth Sci Ctr, Postgrad Program Phys Educ, Natal, RN, Brazil.; Fayh, APT (corresponding author), Univ Fed Rio Grande do Norte, Hlth Sci Ctr, Dept Nutr, Natal, RN, Brazil.
EM apfayh@yahoo.com.br
RI Muller, Carlos/AAP-1890-2020; Peres, Alessandra/W-7190-2018; Souza,
   Daniel/AAW-3239-2021; Krause, Mauricio/AAF-1160-2019; Dorneles,
   Gilson/D-5474-2019; Caldas Costa, Eduardo/X-7891-2018
OI Caldas Costa, Eduardo/0000-0003-2807-7109; matos,
   victor/0000-0003-4995-7922; Marinho, Cristiane da Silva
   Ramos/0000-0003-3825-3057; Krause, Mauricio/0000-0001-9814-742X; de
   Lemos Muller, Carlos Henrique/0000-0003-0205-7775
FU Ministry of Science, Technology, Innovation and Communication of Brazil
   [14-2014, 447741/2014-4]
FX The present study was supported by the Ministry of Science, Technology,
   Innovation and Communication of Brazil (Edital Universal
   MCTI/CNPq/Universal 14-2014, Process 447741/2014-4).
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NR 50
TC 54
Z9 56
U1 0
U2 13
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-042X
J9 FRONT PHYSIOL
JI Front. Physiol.
PD MAY 23
PY 2018
VL 9
AR 567
DI 10.3389/fphys.2018.00567
PG 9
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA GG6ZQ
UT WOS:000432847900001
PM 29875681
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Lamichhane, G
   Lee, DY
   Franks, R
   Olawale, F
   Jin, JB
   Egan, JM
   Kim, Y
AF Lamichhane, Gopal
   Lee, Da-Yeon
   Franks, Rienna
   Olawale, Femi
   Jin, Jong-Beom
   Egan, Josephine M.
   Kim, Yoo
TI Curcumin-Rich Diet Mitigates Non-Alcoholic Fatty Liver Disease (NAFLD)
   by Attenuating Fat Accumulation and Improving Insulin Sensitivity in
   Aged Female Mice under Nutritional Stress
SO BIOLOGY-BASEL
LA English
DT Article
DE curcumin; aging; NAFLD; obesity; insulin resistance
ID WEIGHT MANAGEMENT; ABDOMINAL OBESITY; PREVALENCE; RESISTANCE; RISK;
   GENE; SEX
AB Simple Summary This study aimed to understand how dietary curcumin influences metabolic abnormalities induced by a high-fat high-sugar diet (HFHSD) in aged female mice. We observed that curcumin effectively reduced body fat accumulation, steatosis of liver, and insulin resistance caused by a nutritional challenge, suggesting its potential in mitigating age-related metabolic disturbances. These findings highlight curcumin supplementation as a potential strategy to address metabolic issues associated with female aging.Abstract Background: The high incidence of metabolic syndrome in the elderly poses a significant challenge to the healthcare system, emphasizing the need for interventions tailored to geriatric patients. Given the limited focus on females in previous studies, this research aimed to evaluate the effects of dietary curcumin on obesity and NAFLD outcomes in naturally aged (18-month-old) female mice. Methods: Female C57BL/6 mice aged 18 months were fed a normal chow diet (NCD) and a HFHSD, with or without curcumin (0.4% w/w), for an 8-week period. Parameters included food intake, body weight, insulin tolerance test (ITT), glucose tolerance test (GTT), percentage fat mass, hepatic triglyceride, and cholesterol levels, and a histological examination for NAFLD detection, qPCR, and immunoblotting analyses were performed. Results: The cumulative body weight gain after 8 weeks in the aged female mice supplemented with curcumin and fed an HFHSD was significantly lower (10.84 +/- 1.09 g) compared to those fed a HFHSD alone (15.28 +/- 1.26 g). Curcumin supplementation also resulted in reduced total body fat (HFHSD group 50.83 +/- 1.71% vs. HFHSD+CUR 41.46 +/- 3.21%), decreased epidydimal fat mass (HFHSD: 3.79 +/- 0.29 g vs. HFHSD+CUR: 2.66 +/- 0.30 g), and repaired adipogenic signaling in the white adipose tissue. Furthermore, curcumin lowered triglyceride and cholesterol deposition in the liver, preventing hepatic steatosis and improving hepatic insulin sensitivity. Conclusions: Curcumin demonstrates the ability to ameliorate the deleterious effects of HFHSD in aged female mice by reducing body fat composition, modulating adipogenic signaling in the white adipose tissue, and improving insulin homeostasis and non-alcoholic fatty deposition in the liver.
C1 [Lamichhane, Gopal; Lee, Da-Yeon; Franks, Rienna; Olawale, Femi; Jin, Jong-Beom; Kim, Yoo] Oklahoma State Univ, Dept Nutr Sci, Stillwater, OK 74078 USA.
   [Egan, Josephine M.] NIA, Lab Clin Invest, Baltimore, MD 21224 USA.
C3 Oklahoma State University System; Oklahoma State University -
   Stillwater; National Institutes of Health (NIH) - USA; NIH National
   Institute on Aging (NIA)
RP Kim, Y (corresponding author), Oklahoma State Univ, Dept Nutr Sci, Stillwater, OK 74078 USA.
EM gopal.lamichhane@okstate.edu; dayeon.lee@okstate.edu;
   rienna.franks@okstate.edu; femi.olawale@okstate.edu; jojin@okstate.edu;
   eganj@grc.nia.nih.gov; yoo.kim@okstate.edu
RI Olawale, Femi/JEO-9218-2023; lamichhane, Gopal/AHD-4491-2022
OI lamichhane, Gopal/0000-0003-1487-7578; Kim, Yoo/0000-0002-4525-1319;
   Lee, Da-Yeon/0000-0002-4085-0689
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NR 66
TC 2
Z9 2
U1 4
U2 7
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2079-7737
J9 BIOLOGY-BASEL
JI Biology-Basel
PD JUL
PY 2024
VL 13
IS 7
AR 472
DI 10.3390/biology13070472
PG 15
WC Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics
GA ZP8F3
UT WOS:001276584100001
PM 39056667
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Mo, MQ
   Pan, L
   Deng, L
   Liang, M
   Xia, N
   Liang, YZ
AF Mo, Manqiu
   Pan, Ling
   Deng, Ling
   Liang, Min
   Xia, Ning
   Liang, Yuzhen
TI Iron Overload Induces Hepatic Ferroptosis and Insulin Resistance by
   Inhibiting the Jak2/stat3/slc7a11 Signaling Pathway
SO CELL BIOCHEMISTRY AND BIOPHYSICS
LA English
DT Article
DE Iron overload; Insulin resistance; Deferasirox; Ferroptosis; JAK2/STAT3
ID CHELATION-THERAPY; METABOLIC SYNDROME; BONE-DISEASE; DEFERASIROX;
   ACTIVATION; ENDOCRINE; STRESS; CANCER; STAT3
AB Recent studies showed that patients with iron overload had increased risk of insulin resistance or diabetes. Ferroptosis is a new type of cell death mainly caused by iron-dependent oxidative damage. In the present study, we investigated potential mechanisms of iron overload induced hepatic ferroptosis and insulin resistance through in vivo and in vitro experiments. In vivo, the mice models of iron overload were established by intraperitoneal injection of iron dextran. The changes of body weight, serum ferritin and blood glucose were measured. Hematoxylin-eosin (HE) and Perl's stainings were used to observe the pathological changes and iron deposition in the liver of mice. In vitro, HepG2 cells were treated with ferric ammonium citrate (FAC, 9 mmol/L, 24 h) to establish the cell models of iron overload. The labile iron pool, cell viability, glucose consumption and glycogen contents were measured. The ultrastructure of mitochondria was observed by transmission electron microscope (TEM). The malondialdehyde (MDA) and glutathione (GSH) kits were used to detect lipid peroxidation in liver tissues of mice and HepG2 cells. RT-PCR and Western blot were used to detect the mRNA and protein expression levels of ferroptosis factors and JAK2/STAT3 signaling pathway. In this study, we used the iron chelator deferasirox in mice and HepG2 cells. Iron overload caused weight loss, elevated serum ferritin, fasting blood glucose, fasting insulin, HOMA-IR, impaired glucose tolerance, and decreased insulin sensitivity in mice. HE staining and Perls staining showed clumps of iron deposition in the liver of iron overload mice. Iron overload could reduce the glucose consumption, increase MDA contents of HepG2 cells, while reduce glycogen and GSH contents in liver tissues of mice and HepG2 cells. TEM showed deletion of mitochondrial ridge and rupture of outer membrane in HepG2 cells with iron overload. Iron chelator deferasirox could significantly improve the above indicators, which might be related to the activation of JAK2/STAT3/SLC7A11 signaling pathway and hepatic ferroptosis. Iron overload could induce hepatic ferroptosis and insulin resistance by inhibiting the JAK2/STAT3/SLC7A11 signaling pathway, and the iron chelator deferasirox might improve hepatic insulin resistance induced by iron overload.
C1 [Mo, Manqiu; Liang, Min; Xia, Ning] Guangxi Med Univ, Affiliated Hosp 1, Geriatr Dept Endocrinol, Nanning, Peoples R China.
   [Pan, Ling] Guangxi Med Univ, Affiliated Hosp 1, Dept Nephrol, Nanning, Peoples R China.
   [Deng, Ling; Liang, Yuzhen] Guangxi Med Univ, Affiliated Hosp 2, Dept Endocrinol, Nanning, Peoples R China.
C3 Guangxi Medical University; Guangxi Medical University; Guangxi Medical
   University
RP Xia, N (corresponding author), Guangxi Med Univ, Affiliated Hosp 1, Geriatr Dept Endocrinol, Nanning, Peoples R China.; Liang, YZ (corresponding author), Guangxi Med Univ, Affiliated Hosp 2, Dept Endocrinol, Nanning, Peoples R China.
EM ningxiagxmu@163.com; liangyuzhen26@163.com
FU Middle/ Young aged Teachers' Research Ability Improvement Project of
   Guangxi Higher Education
FX No Statement Available
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NR 60
TC 4
Z9 4
U1 3
U2 10
PU HUMANA PRESS INC
PI TOTOWA
PA 999 RIVERVIEW DRIVE SUITE 208, TOTOWA, NJ 07512 USA
SN 1085-9195
EI 1559-0283
J9 CELL BIOCHEM BIOPHYS
JI Cell Biochem. Biophys.
PD SEP
PY 2024
VL 82
IS 3
BP 2079
EP 2094
DI 10.1007/s12013-024-01315-8
EA MAY 2024
PG 16
WC Biochemistry & Molecular Biology; Biophysics; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Cell Biology
GA H6B3R
UT WOS:001234308000002
PM 38801513
DA 2025-06-11
ER

PT J
AU Li, XX
   Xue, YX
   Zhang, YD
   Wang, QA
   Qiu, JW
   Zhang, JX
   Yang, C
   Zhao, Y
   Zhang, YH
AF Li, Xiaoxia
   Xue, Yixuan
   Zhang, Yadi
   Wang, Qingan
   Qiu, Jiangwei
   Zhang, Jiaxing
   Yang, Chan
   Zhao, Yi
   Zhang, Yuhong
TI Association between dietary antioxidant capacity and type 2 diabetes
   mellitus in Chinese adults: a population-based cross-sectional study
SO NUTRITION & METABOLISM
LA English
DT Article
DE Type 2 diabetes mellitus; Dietary total antioxidant capacity; Dietary
   antioxidant quality scores
ID METABOLIC SYNDROME; OXIDATIVE STRESS; ZINC SUPPLEMENTATION; RISK;
   CANCER; FRUIT
AB Background Higher intakes of dietary antioxidants have been linked to a lower type 2 diabetes mellitus (T2DM) risk. However, few studies have comprehensively examined the overall dietary antioxidant capacity, assessed by dietary antioxidant quality scores (DAQS) and dietary total antioxidant capacity (DTAC), related to T2DM risk, especially in populations consuming relatively monotonous diets. This study aimed to evaluate the associations of DAQS, DTAC, and T2DM among rural Chinese adults. Methods Data from 12,467 participants from the Natural Population Cohort of Northwest China: Ningxia Project was analyzed. Dietary intake was assessed using a validated semi-quantitative food frequency questionnaire. DAQS were calculated based on vitamins A, C, and E, zinc (Zn), and selenium (Se) intake. DTAC was estimated using the ferric-reducing ability of plasma assay. Logistic regression models were used to evaluate the associations of DAQS and DTAC with T2DM risk. Restricted cubic splines were used to assess potential non-linear relationships between DTAC and T2DM. Results T2DM was observed in 1,238 (9.9%) participants. After adjusting for confounders, compared to the lowest tertiles (T1) of DAQS, the odds ratios (ORs) for T2DM were 1.03 (95% CI 0.82-1.30) in T2 and 0.85 (95% CI 0.68-1.06) in T3 (P = 0.010). Compared to T1, the ORs for T2DM in the highest T3 were 0.78 (95% CI 0.67-0.91, P-trend = 0.008) for vitamin A, 1.34 (95% CI 1.15-1.56, P-trend < 0.001) for vitamin E, 0.83 (95% CI 0.71-0.97, P-trend = 0.007) for Se, and 0.86 (95% CI 0.74-1.01, P-trend = 0.033) for Zn. Compared to the lowest quartile(Q1) of DTAC, the OR in the highest Q4 was 0.96 (95% CI 0.80-1.17, P-trend = 0.024) for T2DM. A non-linear relationship was observed between DATC and T2DM. Conclusion Higher DAQS and DATC were associated with a lower T2DM risk, suggesting that consuming antioxidant-rich foods may reduce the T2DM risk.
C1 [Li, Xiaoxia; Xue, Yixuan; Zhang, Yadi; Wang, Qingan; Qiu, Jiangwei; Zhang, Jiaxing; Yang, Chan; Zhao, Yi; Zhang, Yuhong] Ningxia Med Univ, Key Lab Environm Factors & Chron Dis Control, Yinchuan 750004, Peoples R China.
   [Li, Xiaoxia; Xue, Yixuan; Zhang, Yadi; Wang, Qingan; Qiu, Jiangwei; Zhang, Jiaxing; Yang, Chan; Zhao, Yi; Zhang, Yuhong] Ningxia Med Univ, NHC Key Lab Metab Cardiovasc Dis Res, Yinchuan 750004, Peoples R China.
   [Li, Xiaoxia; Xue, Yixuan; Zhang, Yadi; Wang, Qingan; Qiu, Jiangwei; Zhang, Jiaxing; Yang, Chan; Zhao, Yi; Zhang, Yuhong] Ningxia Med Univ, Sch Publ Hlth, Yinchuan 750004, Peoples R China.
C3 Ningxia Medical University; Ningxia Medical University; Ningxia Medical
   University
RP Zhao, Y; Zhang, YH (corresponding author), Ningxia Med Univ, Key Lab Environm Factors & Chron Dis Control, Yinchuan 750004, Peoples R China.; Zhao, Y; Zhang, YH (corresponding author), Ningxia Med Univ, NHC Key Lab Metab Cardiovasc Dis Res, Yinchuan 750004, Peoples R China.; Zhao, Y; Zhang, YH (corresponding author), Ningxia Med Univ, Sch Publ Hlth, Yinchuan 750004, Peoples R China.
EM zhaoyi751114@hotmail.com; zhangyh@nxmu.edu.cn
RI Qiu, bobo/JRY-3876-2023; Zhao, Jiajun/W-2963-2018
FU Natural Science Foundation of Ningxia Province
FX We thank all participants and staff working for the China Northwest
   Natural Population Cohort, Ningxia Project.
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NR 52
TC 6
Z9 6
U1 3
U2 11
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1743-7075
J9 NUTR METAB
JI Nutr. Metab.
PD MAR 29
PY 2024
VL 21
IS 1
AR 16
DI 10.1186/s12986-024-00786-z
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA MR6Q5
UT WOS:001195403100001
PM 38553719
OA gold
DA 2025-06-11
ER

PT J
AU Ito, S
   Nakashima, H
   Ishikiriyama, T
   Nakashima, M
   Yamagata, A
   Imakiire, T
   Kinoshita, M
   Seki, S
   Kumagai, H
   Oshima, N
AF Ito, Seigo
   Nakashima, Hiroyuki
   Ishikiriyama, Takuya
   Nakashima, Masahiro
   Yamagata, Akira
   Imakiire, Toshihiko
   Kinoshita, Manabu
   Seki, Shuhji
   Kumagai, Hiroo
   Oshima, Naoki
TI Effects of a CCR2 antagonist on macrophages and Toll-like receptor 9
   expression in a mouse model of diabetic nephropathy
SO AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
LA English
DT Article
DE C-C chemokine receptor type 2; diabetic nephropathy; macrophage;
   Toll-like receptor 9; tumor necrosis factor-alpha
ID RENAL INJURY; PHARMACOLOGICAL CHARACTERIZATION;
   ALPHA-GALACTOSYLCERAMIDE; MCP-1/CCR2 SYSTEM; CHEMOKINE; RESIDENT;
   PROGRESSION; PROMOTES; CELLS; LIVER
AB The pathogenesis of diabetic nephropathy (DN) is related to macrophage (M phi) recruitment to the kidneys, tumor necrosis factor-alpha (TNF-alpha) production, and oxidative stress. Toll-like receptor 9 (TLR9) activation is reportedly involved in systemic inflammation, and it exacerbates this condition in metabolic syndrome. Therefore, we hypothesized that TLR9 plays a role in the pathogenesis of DN. Two subsets of kidney M phi s in DN model (db/db) mice were analyzed using flow cytometry to evaluate their distribution and TLR9 expression and function. Mice were administered the CCR2 antagonist INCB3344 for 8 wk; changes in M phi distribution and function and its therapeutic effects on DN pathology were examined. Bone marrow-derived CD11b(high) (BM-M phi) and tissue-resident CD11b(low) M phi s (Res-M phi) were identified in the mouse kidneys. As DN progressed, the BM-M phi number, TLR9 expression, and TNF-alpha production increased significantly. In Res-M phi s, reactive oxygen species (ROS) production and phagocytic activity were enhanced. INCB3344 decreased albuminuria, serum creatinine level, BM-M phi abundance, TLR9 expression, and TNF-alpha production by BM-M phi s and ROS production by Res-M phi s. Both increased activation of BM-M phi via TLR9 and TNF-alpha production and increased ROS production by Res-M phi s were involved in DN progression. Thus, inactivating M phi s and their TLR9 expression by INCB3344 is a potential therapeutic strategy for DN.
   NEW & NOTEWORTHY We classified kidney macrophages (M phi s) into bone marrow-derived M phi s (BM-M phi s) expressing high CD11b and tissue-specific resident Mop (Res-M phi s) expressing low CD11b. In diabetic nephropathy (DN) model mice, Toll-like receptor 9 (TLR9) expression and TNF-alpha production via TLR9 activation in BM-M phi s and ROS production in Res-M phi s were enhanced. Furthermore, CCR2 antagonist suppressed the kidney infiltration of BM-M phi s and their function and the ROS production by Res-M phi s, with concomitant TLR9 suppression. Our study presents a new therapeutic strategy for DN.
C1 [Ito, Seigo; Yamagata, Akira; Imakiire, Toshihiko; Kumagai, Hiroo; Oshima, Naoki] Natl Def Med Coll, Dept Nephrol & Endocrinol, Tokorozawa, Saitama, Japan.
   [Nakashima, Hiroyuki; Ishikiriyama, Takuya; Nakashima, Masahiro; Kinoshita, Manabu; Seki, Shuhji] Natl Def Med Coll, Dept Immunol & Microbiol, Tokorozawa, Saitama, Japan.
C3 National Defense Medical College - Japan; National Defense Medical
   College - Japan
RP Ito, S (corresponding author), Natl Def Med Coll, Dept Nephrol & Endocrinol, Tokorozawa, Saitama, Japan.
EM sitoh@ndmc.ac.jp
OI Nakashima, Hiroyuki/0000-0001-6066-3031
FU National Defense Medical College; Grants-in-Aid for Scientific Research
   [21H03038, 20K07438] Funding Source: KAKEN
FX GRANTS This work was supported by grants from National Defense Medical
   College to our department.
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NR 62
TC 22
Z9 24
U1 2
U2 10
PU AMER PHYSIOLOGICAL SOC
PI Rockville
PA 6120 Executive Blvd, Suite 600, Rockville, MD, UNITED STATES
SN 1931-857X
EI 1522-1466
J9 AM J PHYSIOL-RENAL
JI Am. J. Physiol.-Renal Physiol.
PD DEC
PY 2021
VL 321
IS 6
BP F757
EP F770
DI 10.1152/ajprenal.00191.2021
PG 14
WC Physiology; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology; Urology & Nephrology
GA XL9OH
UT WOS:000728468100006
PM 34719947
OA hybrid, Green Submitted
DA 2025-06-11
ER

PT J
AU Terock, J
   Hannemann, A
   Van der Auwera, S
   Janowitz, D
   Spitzer, C
   Bonk, S
   Völzke, H
   Grabe, HJ
AF Terock, Jan
   Hannemann, Anke
   Van der Auwera, Sandra
   Janowitz, Deborah
   Spitzer, Carsten
   Bonk, Sarah
   Voelzke, Henry
   Grabe, Hans Joergen
TI Posttraumatic stress disorder is associated with reduced vitamin D
   levels and functional polymorphisms of the vitamin D binding-protein in
   a population-based sample
SO PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
LA English
DT Article
DE Vitamin D; Vitamin D binding-protein; rs4588; rs7041; PTSD
ID GROUP-SPECIFIC COMPONENT; ANGIOTENSIN-ALDOSTERONE-SYSTEM; D DEFICIENCY;
   D-RECEPTOR; PLASMA-CONCENTRATIONS; METABOLIC SYNDROME; D
   SUPPLEMENTATION; GC-GLOBULIN; PTSD; GENE
AB Objective: Low levels of vitamin D were found to be associated with different mental disorders. However, the role of vitamin D in the pathogenesis of PTSD is unclear. In this study, we aimed at investigating whether PTSD is linked to reduced vitamin D levels and vitamin D deficiency. Moreover, we sought to investigate the role of the vitamin D-binding protein (also group-specific component or Gc) by testing if two functional polymorphisms (rs4588 and rs7041) were associated with vitamin D levels and PTSD.
   Methods: Serum levels of total 25(OH)D were measured in a general-population sample of the Study of Health in Pomerania (SHIP-1). The number of traumatic events and status of PTSD were assessed using the PTSD module of the Structured Clinical Interview for the DSM-IV. Study participants were genotyped for rs4588 and rs7041. Associations of 25(OH)D levels and the genotypes with PTSD were tested in subjects with at least one traumatic event (n=1653).
   Results: 25(OH)D levels were inversely (OR: 0.96; p=0.044) and vitamin D deficiency was positively (OR=2.02; p=0.028) associated with PTSD. Both polymorphisms of the Gc were associated with 25(OH)D levels and PTSD: Carriers of the CC-genotype of rs4588 showed significantly higher 25(OH)D levels (beta=0.179, p < 0.001) and lower odds for PTSD (OR=0.35; p=0.023) compared to the AA-genotype. Likewise, carriers of the TT-allele of rs7041 showed lower 25(OH)D levels (-0.122; p < 0.001) and increased odds for PTSD (OR=2.80; p=0.015) compared to the GG-genotype.
   Conclusions: Our results suggest that an altered vitamin D metabolism may be involved in the pathophysiology of PTSD. Also, genotypes of the Gc and thus Gc serum levels may impact on PTSD development over and above the effects of 25(OH)D. Our findings contribute to explain the associations of PTSD with different mental and physical disorders.
C1 [Terock, Jan] HELIOS Hanseklinikum Stralsund, Dept Psychiat & Psychotherapy, Rostocker Chaussee 70, D-18437 Stralsund, Germany.
   [Terock, Jan; Van der Auwera, Sandra; Janowitz, Deborah; Bonk, Sarah; Grabe, Hans Joergen] Univ Med Greifswald, Dept Psychiat & Psychotherapy, Ellernholzstr 1-2, D-17475 Greifswald, Germany.
   [Hannemann, Anke] Univ Med Greifswald, Inst Clin Chem & Lab Med, Ferdinand Sauerbruch Str, Greifswald, Germany.
   [Van der Auwera, Sandra; Grabe, Hans Joergen] German Ctr Neurodegenerat Dis DZNE, Site Rostock Greifswald, Ellernholzstr 1, D-17475 Greifswald, Germany.
   [Spitzer, Carsten] Univ Med Rostock, Dept Psychosomat & Psychotherapeut Med, Gehlsheimer Str 20, D-18147 Rostock, Germany.
   [Voelzke, Henry] Univ Med Greifswald, Inst Community Med, Ellernholzstr 1-2, Greifswald, Germany.
   [Hannemann, Anke] Univ Med Greifswald, German Ctr Cardiovasc Res DZHK, Partner Site Greifswald, Ferdinand Sauerbruch Str, D-17475 Greifswald, Germany.
C3 Universitat Greifswald; Greifswald Medical School; Universitat
   Greifswald; Greifswald Medical School; Helmholtz Association; German
   Center for Neurodegenerative Diseases (DZNE); University of Rostock;
   Universitat Greifswald; Greifswald Medical School; Universitat
   Greifswald; Greifswald Medical School; German Centre for Cardiovascular
   Research
RP Terock, J (corresponding author), Univ Med Greifswald, Dept Psychiat & Psychotherapy, HELIOS Klinikum Stralsund, Rostocker Chaussee 70, D-18437 Stralsund, Germany.
EM jan.terock@helios-gesundheit.de
RI Terock, Jan/ABB-6392-2020
FU Federal Ministry of Education and Research [01ZZ9603, 01ZZ0103,
   01ZZ0403, 03IS2061A, 03ZIK012]; Ministry of Cultural Affairs; Social
   Ministry of the Federal State of Mecklenburg-West Pomerania; Siemens
   Healthineers, Erlangen, Germany; Federal State of Mecklenburg- West
   Pomerania; Deutsche Forschungsgemeinschaft (DFG) [257691738]; Germany
   Ministry of Education and Research (BMBF); DAMP Foundation; EU "Joint
   Program Neurodegenerative Disorders"; German Federal Ministry of
   Education and Research (BMBF) [01ZX1614E]
FX SHIP is part of the Community Medicine Research net of the University of
   Greifswald, Germany, which is funded by the Federal Ministry of
   Education and Research (grants no. 01ZZ9603, 01ZZ0103, and 01ZZ0403),
   the Ministry of Cultural Affairs as well as the Social Ministry of the
   Federal State of Mecklenburg-West Pomerania, and the network 'Greifswald
   Approach to Individualized Medicine (GANI_MED)' funded by the Federal
   Ministry of Education and Research (grant 03IS2061A). Genome-wide data
   have been supported by the Federal Ministry of Education and Research
   (grant no. 03ZIK012) and a joint grant from Siemens Healthineers,
   Erlangen, Germany and the Federal State of Mecklenburg- West Pomerania.
   The University of Greifswald is a member of the Cache Campus program of
   the InterSystems GmbH. HJG received research funding from the Deutsche
   Forschungsgemeinschaft (DFG), the Germany Ministry of Education and
   Research (BMBF), DAMP Foundation, the EU "Joint Program
   Neurodegenerative Disorders". SV was funded by the German Federal
   Ministry of Education and Research (BMBF) within the framework of the
   e:Med research and funding concept (Integrament; grant no. 01ZX1614E).
   DJ was funded by the Deutsche Forschungsgemeinschaft (grant no.
   257691738).
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NR 80
TC 16
Z9 17
U1 1
U2 32
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0278-5846
EI 1878-4216
J9 PROG NEURO-PSYCHOPH
JI Prog. Neuro-Psychopharmacol. Biol. Psychiatry
PD JAN 10
PY 2020
VL 96
AR 109760
DI 10.1016/j.pnpbp.2019.109760
PG 9
WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA JG2DL
UT WOS:000491886400021
PM 31518608
DA 2025-06-11
ER

PT J
AU Mason, AE
   Hecht, FM
   Daubenmier, JJ
   Sbarra, DA
   Lin, J
   Moran, PJ
   Schleicher, SG
   Acree, M
   Prather, AA
   Epel, ES
AF Mason, Ashley E.
   Hecht, Frederick M.
   Daubenmier, Jennifer J.
   Sbarra, David A.
   Lin, Jue
   Moran, Patricia J.
   Schleicher, Samantha G.
   Acree, Michael
   Prather, Aric A.
   Epel, Elissa S.
TI Weight Loss Maintenance and Cellular Aging in the Supporting Health
   Through Nutrition and Exercise Study
SO PSYCHOSOMATIC MEDICINE
LA English
DT Article
DE behavioral intervention; mindfulness; telomere length; weight loss
   maintenance
ID LEUKOCYTE TELOMERE LENGTH; BODY-MASS INDEX; METABOLIC SYNDROME;
   PHYSICAL-ACTIVITY; HUMAN T; CARDIOVASCULAR-DISEASE; LOSS INTERVENTION;
   STRESS; ASSOCIATION; LIFE
AB Objective The aim of the study was to determine, within a weight loss clinical trial for obesity, the impact of intervention arm, weight change, and weight loss maintenance on telomere length (TL).
   Methods Adults (N = 194) with a body mass index between 30 and 45 were randomized to a 5.5-month weight loss program with (n = 100) or without (n = 94) mindfulness training and identical diet-exercise guidelines. We assessed TL at baseline and 3-, 6-, and 12-month postbaseline in immune cell populations (primarily in peripheral blood mononuclear cells [PBMCs], but also in granulocytes and T and B lymphocytes). We defined weight loss maintenance as having lost at least 5% or 10% of body weight (tested in separate models) from preintervention to postintervention, and having maintained this loss at 12 months. We predicted that greater weight loss and weight loss maintenance would be associated with TL lengthening.
   Results Neither weight loss intervention significantly predicted TL change nor did amount of weight change, at any time point. Across all participants, weight loss maintenance of at least 10% was associated with longer PBMC TL (b = 239.08, 95% CI = 0.92 to 477.25, p = .049), CD8+ TL (b = 417.26, 95% CI = 58.95 to 775.57, p = .023), and longer granulocyte TL (b = 191.56, 95% CI = -4.23 to 387.35, p = .055) at 12 months after accounting for baseline TL. Weight loss maintenance of 5% or more was associated with longer PBMC TL (b = 163.32, 95% CI = 4.00 to 320.62, p = .045) at 12 months after accounting for baseline TL. These tests should be interpreted in light of corrections for multiple tests.
   Conclusions Among individuals with obesity, losing and maintaining a weight loss of 10% or more may lead to TL lengthening, which may portend improved immune and metabolic function. TL lengthening in this study is of unknown duration beyond 12 months and requires further study. Trial Registration: Clinicaltrials.gov identifier NCT00960414; Open Science Framework (OSF) preregistration: https://osf.io/t3r2g/.
C1 [Mason, Ashley E.; Schleicher, Samantha G.; Prather, Aric A.; Epel, Elissa S.] UCSF, Ctr Hlth & Community, Dept Psychiat, San Francisco, CA USA.
   [Mason, Ashley E.; Hecht, Frederick M.; Moran, Patricia J.; Schleicher, Samantha G.; Acree, Michael; Epel, Elissa S.] UCSF, Osher Ctr Integrat Med, San Francisco, CA USA.
   [Daubenmier, Jennifer J.] SF State Univ, Inst Holist Hlth Studies, Dept Hlth Educ, San Francisco, CA USA.
   [Sbarra, David A.] Univ Arizona, Dept Psychol, Tucson, AZ 85721 USA.
   [Lin, Jue] UCSF, Dept Biochem & Biophys, San Francisco, CA USA.
C3 University of California System; University of California San Francisco;
   University of California System; University of California San Francisco;
   California State University System; San Francisco State University;
   University of Arizona; University of California System; University of
   California San Francisco
RP Mason, AE (corresponding author), Univ Calif San Francisco, San Francisco Osher Ctr Integrat Med, 1545 Divisadero St,Suite 301, San Francisco, CA 94115 USA.
EM ashley.mason@ucsf.edu
RI Mason, Ashley/JXL-5014-2024; Epel, Elissa/ABI-6703-2022
FU National Institutes of Health (NIH) from the National Heart, Lung, and
   Blood Institute (NHLBI) [K23HL133442]; National Institutes of Health
   (NIH) from the National Center for Complementary and Integrative Health
   (NCCIH) [P01AT005013, K24AT007827, K01AT004199]; National Institutes of
   Health (NIH) from the National Center for Advancing Translational
   Sciences, UCSF-CTSI [UL1TR000004]; National Center for Complementary and
   Integrative Health [K24AT007827, T32AT003997] Funding Source: NIH
   RePORTER
FX This research was supported by National Institutes of Health (NIH)
   grants from the National Heart, Lung, and Blood Institute (NHLBI)
   K23HL133442 (Mason), the National Center for Complementary and
   Integrative Health (NCCIH) P01AT005013 (Hecht), K24AT007827 (Hecht), and
   K01AT004199 (Daubenmier), and the National Center for Advancing
   Translational Sciences, UCSF-CTSI Grant Number UL1TR000004. All authors
   declare no conflicts of interest.
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NR 77
TC 22
Z9 22
U1 0
U2 21
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0033-3174
EI 1534-7796
J9 PSYCHOSOM MED
JI Psychosom. Med.
PD SEP
PY 2018
VL 80
IS 7
BP 609
EP 619
DI 10.1097/PSY.0000000000000616
PG 11
WC Psychiatry; Psychology; Psychology, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry; Psychology
GA GS8IY
UT WOS:000443954400003
PM 29901486
OA Green Accepted, Green Published
DA 2025-06-11
ER

PT J
AU Cramer, H
   Lauche, R
   Haller, H
   Steckhan, N
   Michalsen, A
   Dobos, G
AF Cramer, Holger
   Lauche, Romy
   Haller, Heidemarie
   Steckhan, Nico
   Michalsen, Andreas
   Dobos, Gustav
TI Effects of yoga on cardiovascular disease risk factors: A systematic
   review and meta-analysis
SO INTERNATIONAL JOURNAL OF CARDIOLOGY
LA English
DT Review
DE Cardiovascular diseases; Hypertension; Metabolic syndrome; Type 2
   diabetes; Yoga; Meta-analysis
ID TYPE-2 DIABETES-MELLITUS; OXIDATIVE STRESS; LIPID PROFILE;
   BLOOD-PRESSURE; METABOLIC PARAMETERS; PHYSICAL-FITNESS; EXERCISE
   THERAPY; GLOBAL BURDEN; BIO-FEEDBACK; MANAGEMENT
AB Background: The aim of this review was to systematically assess and meta-analyze the effects of yoga on modifiable biological cardiovascular disease risk factors in the general population and in high-risk disease groups.
   Methods: MEDLINE/PubMed, Scopus, the Cochrane Library, and IndMED were screened through August 2013 for randomized controlled trials (RCTs) on yoga for predefined cardiovascular risk factors in healthy participants, non-diabetic participants with high risk for cardiovascular disease, or participants with type 2 diabetes mellitus. Risk of bias was assessed using the Cochrane risk of bias tool.
   Results: Forty-four RCTs with a total of 3168 participants were included. Risk of bias was high or unclear for most RCTs. Relative to usual care or no intervention, yoga improved systolic (mean difference (MD)=-5.85 mm Hg; 95% confidence interval (CI) = -8.81, -2.89) and diastolic blood pressure (MD = -4.12 mm Hg; 95% CI = -6.55, -1.69), heart rate (MD = -6.59 bpm; 95% CI = -12.89, -0.28), respiratory rate (MD = -0.93 breaths/min; 95% CI = -1.70, -0.15), waist circumference (MD = -1.95 cm; 95% CI = -3.01, -0.89), waist/hip ratio (MD = -0.02; 95% CI = -0.03, -0.00), total cholesterol (MD = -13.09 mg/dl; 95% CI = -19.60, -6.59), HDL (MD = 2.94 mg/dl; 95% CI = 0.57, 5.31), VLDL (MD= -5.70 mg/dl; 95% CI = -7.36, -4.03), triglycerides (MD = -20.97 mg/dl; 95% CI = -28.61, -13.32), HbA1c (MD = -0.45%; 95% CI=-0.87,-0.02), and insulin resistance (MD=-0.19; 95% CI=-0.30,-0.08). Relative to exercise, yoga improved HDL (MD= 3.70 mg/dl; 95% CI = 1.14, 6.26).
   Conclusions: This meta-analysis revealed evidence for clinically important effects of yoga on most biological cardiovascular disease risk factors. Despite methodological drawbacks of the included studies, yoga can be considered as an ancillary intervention for the general population and for patients with increased risk of cardiovascular disease. (c) 2014 Elsevier Ireland Ltd. All rights reserved.
C1 [Cramer, Holger; Lauche, Romy; Haller, Heidemarie; Dobos, Gustav] Univ Duisburg Essen, Fac Med, Kliniken Essen Mitte, Dept Internal & Integrat Med, Essen, Germany.
   [Steckhan, Nico; Michalsen, Andreas] Immanuel Hosp Berlin, Dept Internal & Complementary Med, Berlin, Germany.
   [Steckhan, Nico; Michalsen, Andreas] Charite Univ Med Berlin, Inst Sozialmed Epidemiol & Gesundheitsokon, Berlin, Germany.
C3 Kliniken Essen-Mitte; University of Duisburg Essen; Berlin Institute of
   Health; Free University of Berlin; Humboldt University of Berlin;
   Charite Universitatsmedizin Berlin
RP Cramer, H (corresponding author), Kliniken Essen Mitte, Knappschafts Krankenhaus, Klin Nat Heilkunde & Integrat Med, Deimelsberg 34a, D-45276 Essen, Germany.
EM h.cramer@kliniken-essen-mitte.de
RI Haller, Heidemarie/AAX-5927-2021; Cramer, Holger/AAH-1794-2019; Lauche,
   Romy/AAQ-7175-2021
OI Lauche, Romy/0000-0002-4171-7935; Steckhan, Nico/0000-0003-0245-2046;
   Haller, Heidemarie/0000-0001-7973-4071; Cramer,
   Holger/0000-0002-3640-8046
FU Corona-Foundation, Germany
FX This review was supported by a grant from the Corona-Foundation,
   Germany. The funding source had no influence on the design or conduct of
   the review; the collection, management, analysis, or interpretation of
   the data; or in the preparation, review, or approval of the manuscript.
   The authors would like to express their appreciation to Dr. Petra Klose,
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   Greenhalgh, London, UK, and to Dr. Lily O'Hara, Abu Dhabi, United Arab
   Emirates for providing the raw data of Ref. [117] and [91],
   respectively.
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NR 142
TC 172
Z9 193
U1 1
U2 71
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0167-5273
EI 1874-1754
J9 INT J CARDIOL
JI Int. J. Cardiol.
PD MAY 1
PY 2014
VL 173
IS 2
BP 170
EP 183
DI 10.1016/j.ijcard.2014.02.017
PG 14
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA AF1XW
UT WOS:000334508200016
PM 24636547
DA 2025-06-11
ER

PT J
AU Kim, OY
   Jo, SH
   Jang, Y
   Chae, JS
   Kim, JY
   Hyun, YJ
   Lee, JH
AF Kim, Oh Yoen
   Jo, Seog Hyun
   Jang, Yangsoo
   Chae, Jey Sook
   Kim, Ji Young
   Hyun, Yae Jung
   Lee, Jong Ho
TI G allele at RAGE SNP82 is associated with proinflammatory markers
   in obese subjects
SO NUTRITION RESEARCH
LA English
DT Article
DE RAGEG82S; sRAGE; AGEs; hs-CRP; Humans; Obesity
ID GLYCATION END-PRODUCTS; C-REACTIVE PROTEIN; INFLAMMATORY MARKERS;
   METABOLIC SYNDROME; ENDOTHELIAL-CELLS; MONONUCLEAR-CELLS; SOLUBLE
   RECEPTOR; OXIDANT STRESS; PLASMA; GENE
AB Obesity is closely associated with low-grade inflammation. The Gly82Ser (G82S) polymorphism in the receptor for the advanced glycation end products (RAGE) gene related to RAGE expression is also involved in inflammatory response. We examined the association between RAGEG82S and obesity on soluble RAGE (sPAGE) and inflammatory markers in Korean men. The following were measured: anthropometric and biochemical parameters, RAGEG82S polymorphism, sRAGE, advanced glycation end products (AGEs), and inflammatory markers in men (n = 1252; range, 30-70 years; body mass index [BMI], >= 18.5 kg/m(2)). Allele frequencies satisfied Hardy-Weinberg Equilibrium (G/G: 72.2%, G/S: 25.5%, S/S: 2.3%). RAGEG82S (beta-coefficient = -0.384, P < .001) and BMI (beta-coefficient = -0.168, P = .001) were major factors affecting sRAGE concentrations. In all subjects, those with 'S/S' homozygotes showed the lowest levels of sRAGE (G/G: 1036.3 +/- 40.3, G/S: 807.0 +/- 49.6, S/S: 443.0 +/- 47.8 pg/mL) before (P < .001) and after adjusted for age, BMI, cigarette smoking, and alcohol drinking (P < .001). When subdivided according to BMI of 25 kg/m(2) (Asian Pacific guideline), obese subjects (BMI >= 25 kg/m(2)) had significantly lower levels of sRAGE (831.7 +/- 36.7 vs 1022.7 +/- 47.8 pg/mL, P = .009) and higher levels of high sensitivity C-reactive protein (hs-CRP) (1.10 +/- 0.07 vs 0.72 +/- 0.05 mg/dL, P < .001) compared with nonobese subjects (BMI < 25 kg/m(2)). Particularly in obese subjects, S/S carriers showed significantly higher concentrations of AGEs (P = .0 12) and hs-CRP (P = .006) than G allele carriers, whereas nonobese people had no significant RAGEG82S-related differences in AGEs (P = .743) and hs-CRP (P = .436). In conclusion, G allele at RAGEG82S may be more associated with inflammatory markers under obese status than nonobese conditions. In this case, it may help to suggest proper dietary modification for controlling obesity to people with genetic variants. (c) 2009 Elsevier Inc. All fights reserved.
C1 [Kim, Oh Yoen; Chae, Jey Sook; Kim, Ji Young; Hyun, Yae Jung; Lee, Jong Ho] Yonsei Univ, Coll Human Ecol, Dept Food & Nutr, Clin Nutrigenet Nutrigenom Lab, Seoul 120749, South Korea.
   [Kim, Oh Yoen; Jang, Yangsoo; Chae, Jey Sook; Kim, Ji Young; Lee, Jong Ho] Yonsei Univ, Res Inst Sci Aging, Seoul 120749, South Korea.
   [Jo, Seog Hyun; Jang, Yangsoo] Yonsei Univ, Grad Sch, Interdisciplinary Program Sci Aging, Seoul 120749, South Korea.
   [Jang, Yangsoo] Yonsei Univ, Yonsei Med Inst, Cardiovasc Genome Ctr, Div Cardiol, Seoul 120749, South Korea.
   [Hyun, Yae Jung; Lee, Jong Ho] Yonsei Univ, Coll Human Ecol, Dept Food & Nutr, Brain Korea Project 21, Seoul 120749, South Korea.
C3 Yonsei University; Yonsei University; Yonsei University; Yonsei
   University; Yonsei University
RP Lee, JH (corresponding author), Yonsei Univ, Coll Human Ecol, Dept Food & Nutr, Clin Nutrigenet Nutrigenom Lab, 134 Shinchon Dong, Seoul 120749, South Korea.
EM ohkitc@yonsei.ac.kr
RI Jang, Yang/D-4803-2012; Kim, Ji Young/HNS-6229-2023; Kim,
   Oh/AAA-6492-2022
OI Jang, Yangsoo/0000-0002-2169-3112
FU Korea Science and Engineering Foundation (KOSEF), Seoul, Korea; Ministry
   of Science Technology [M10642120002-06N4212-00210]; National Research
   Laboratory Program [R0A-2005-000-10144-0]; Korea Health 21 R&D Projects,
   Seoul, Korea; Brain Korea 21 Project, Yonsei University College of Human
   Ecology, Seoul, Korea
FX This study was partly supported by the Korea Science and Engineering
   Foundation (KOSEF), Seoul, Korea; the Ministry of Science & Technology
   (M10642120002-06N4212-00210), Seoul, Korea; the National Research
   Laboratory Program (#R0A-2005-000-10144-0), Seoul, Korea; the Korea
   Health 21 R&D Projects, Seoul, Korea; and the Brain Korea 21 Project,
   Yonsei University College of Human Ecology, Seoul, Korea.
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NR 41
TC 25
Z9 27
U1 0
U2 2
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0271-5317
J9 NUTR RES
JI Nutr. Res.
PD FEB
PY 2009
VL 29
IS 2
BP 106
EP 113
DI 10.1016/j.nutres.2009.01.006
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 424VP
UT WOS:000264596700006
PM 19285601
DA 2025-06-11
ER

PT J
AU Wei, B
   Hu, X
   Shu, BL
   Huang, QY
   Chai, H
   Yuan, HY
   Zhou, L
   Duan, YC
   Yao, LL
   Dong, ZE
   Wu, XR
AF Wei, Bin
   Hu, Xin
   Shu, Ben-Liang
   Huang, Qin-Yi
   Chai, Hua
   Yuan, Hao-Yu
   Zhou, Lin
   Duan, Yi-Chong
   Yao, Li-Li
   Dong, Zhuo-Er
   Wu, Xiao-rong
TI Association of triglyceride-glucose index and derived indices with
   cataract in middle-aged and elderly Americans: NHANES 2005-2008
SO LIPIDS IN HEALTH AND DISEASE
LA English
DT Article
DE TyG; Cataract; Metabolic syndrome
ID OXIDATIVE STRESS; LENS
AB Aim Explore the relationship between the triglyceride-glucose (TyG) index, along with its derivative indices, and the prevalence of cataracts. Methods Data from 20,497 participants in the 2005-2008 National Health and Nutrition Examination Survey (NHANES) were compiled. A final total of 4,499 individuals met the eligibility criteria. Cataract presence was assessed through a self-reported history of cataract surgery. The TyG index and its derivatives-TyG-waist-to-height ratio (WHtR), TyG-neutrophil-to-lymphocyte ratio (NLR), TyG-monocyte-to-lymphocyte ratio (MLR), TyG-log platelet-to-lymphocyte ratio (lgPLR), TyG-log systemic inflammation index (lgSII), and TyG-systemic inflammation response index (SIRI)-were calculated. Statistical analyses included multivariable logistic regression, restricted cubic spline (RCS) curves for nonlinear relationships, and receiver operating characteristic (ROC) analysis. Results Higher TyG indices were significantly associated with cataract presence (P < 0.001). Specifically, TyG-WHtR, TyG-NLR, TyG-lgPLR, TyG-lgSII, and TyG-SIRI exhibited positive correlations with cataract prevalence, even after adjustment for potential confounders (odds ratio [OR] = 1.17; 95% confidence interval [CI]: 1.01, 1.37; P = 0.0403; [OR] = 1.01; 95% [CI]: 1.00, 1.02; P = 0.0258; [OR] = 1.08; 95% [CI]: 1.01, 1.16; P = 0.0223; [OR] = 1.08; 95% [CI]: 1.03, 1.14; P = 0.001; [OR] = 1.02; 95% [CI]: 1.00, 1.04; P = 0.0120). Furthermore, the stratified analysis showed that in the 61-85 age group, TyG-lgPLR and TyG-lgSII remained positively associated with cataract prevalence ([OR] = 1.09; 95% [CI]: 1.01, 1.17; P = 0.024; [OR] = 1.08; 95% [CI]: 1.02, 1.13; P = 0.005). RCS analysis revealed a linear association between these indices and cataracts, with no apparent threshold effect. ROC analysis indicated that TyG-MLR demonstrated the highest predictive ability for cataract presence. Conclusion The study results indicate a positive association between TyG-related indicators and cataract the prevalence of cataracts in middle-aged and elderly individuals, suggesting that these markers may serve as practical biomarkers for identifying high-risk individuals. Early detection and management of metabolic and inflammatory factors could contribute to effective preventive strategies for cataract development in the elderly population.
C1 [Wei, Bin; Hu, Xin; Shu, Ben-Liang; Huang, Qin-Yi; Chai, Hua; Yuan, Hao-Yu; Zhou, Lin; Duan, Yi-Chong; Yao, Li-Li; Dong, Zhuo-Er; Wu, Xiao-rong] Nanchang Univ, Affiliated Hosp 1, Jiangxi Med Coll, Nanchang, Jiangxi, Peoples R China.
C3 Nanchang University
RP Wu, XR (corresponding author), Nanchang Univ, Affiliated Hosp 1, Jiangxi Med Coll, Nanchang, Jiangxi, Peoples R China.
EM wxr98021@126.com
RI Yuan, Haoyu/KBB-7364-2024; Dong, Zhuoer/HNI-0707-2023
FU the National Natural Science Foundation of China; National Health and
   Nutrition Examination Survey (NHANES)
FX We acknowledge the data from the National Health and Nutrition
   Examination Survey (NHANES).
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NR 38
TC 1
Z9 1
U1 2
U2 2
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1476-511X
J9 LIPIDS HEALTH DIS
JI Lipids Health Dis.
PD FEB 14
PY 2025
VL 24
IS 1
AR 48
DI 10.1186/s12944-025-02470-4
PG 11
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA X0K6C
UT WOS:001422349400003
PM 39953544
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Silveira, BKS
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   Hermsdorff, HHM
AF Silveira, Brenda Kelly Souza
   da Silva, Alessandra
   Rocha, Daniela Mayumi Usuda Prado
   Waskow, Karina
   Martino, Hercia Stampini Duarte
   Bressan, Josefina
   Hermsdorff, Helen Hermana Miranda
TI Brazil Nut (Bertholletia excelsa HBK) Consumption in
   Energy-Restricted Intervention Decreases Proinflammatory Markers and
   Intestinal Permeability of Women with Overweight/Obesity: A Controlled
   Trial (Brazilian Nuts Study)
SO JOURNAL OF NUTRITION
LA English
DT Article
DE Brazil nut; gut permeability; intestinal health; meta-in fl ammation;
   selenium
ID OXIDATIVE STRESS; METABOLIC SYNDROME; GUT PERMEABILITY; SELENIUM;
   OBESITY; RISK; BIOMARKERS; WEIGHT; DIET
AB Background: Obesity is associated with low-grade inflammation and increased intestinal permeability (IP). The Brazil nut (BN) (Bertholletia excelsa H.B.K.) appears to be a promising dietary intervention to control inflammation by enhancing antioxidant defenses. Objectives: We aimed to assess the effect of daily BN consumption on inflammatory biomarkers and IP in the context of an energy-restricted intervention. Furthermore, we evaluated the correlation between the changes in these inflammatory markers and the changes in serum selenium and IP. Methods: In this 8-wk nonrandomized controlled trial, 56 women with overweight or obesity were allocated into 2 groups, both following an energy-restricted diet (-500 kcal/d). The control group (CO) consumed a nut-free diet, while the BN group consumed 8 g BN/d, providing 347.2 mu g selenium (Se). Inflammatory cytokines were analyzed in plasma and Se in serum. IP was assessed using the lactulose/mannitol test (LM ratio). Results: Forty-six women completed the intervention. Both groups achieved similar energy restriction (CO Delta= -253.7 +/- 169.4 kcal/d; BN Delta= -265.8 +/- 141.8 kcal/d) and weight loss (CO Delta= -2.5 +/- 0.5 kg; BN Delta= -3.5 +/- 0.5 kg). The BN group showed lower values of C-reactive protein, tumor necrosis factor, interleukin (IL)1-beta, IL-8, percentage lactulose excretion, and LM ratio than the CO group. Additionally, changes in serum Se concentration were predictive of changes in IL-8 concentration (beta: -0.054; adjusted R-2: 0.100; 95% confidence interval [CI]: -0.100; -0.007; P = 0.025), and changes in IL-8 were predictive of changes in the LM ratio (beta: 0.006; adjusted R-2: 0.101; 95% CI: 0.001, 0.011; P = 0.024). Conclusions: Regular intake of BNs can be a promising complementary dietary strategy for controlling low-grade inflammation and improving IP in women with overweight/obesity undergoing energy-restricted treatment. However, the effects of BNs seem to be Se status-dependent.
C1 [Silveira, Brenda Kelly Souza; da Silva, Alessandra; Rocha, Daniela Mayumi Usuda Prado; Waskow, Karina; Bressan, Josefina; Hermsdorff, Helen Hermana Miranda] Univ Fed Vicosa, Dept Nutr & Hlth, Lab Energy Metab & Body Composit, Vicosa, Brazil.
   [Rocha, Daniela Mayumi Usuda Prado; Bressan, Josefina; Hermsdorff, Helen Hermana Miranda] Univ Fed Vicosa, Dept Nutr & Hlth, Lab Clin Anal & Genom, Vicosa, Brazil.
   [Martino, Hercia Stampini Duarte] Univ Fed Vicosa, Dept Nutr & Hlth, Lab Expt Nutr, Vicosa, Brazil.
C3 Universidade Federal de Vicosa; Universidade Federal de Vicosa;
   Universidade Federal de Vicosa
RP Hermsdorff, HHM (corresponding author), Univ Fed Vicosa, Dept Nutr & Hlth, Lab Energy Metab & Body Composit, Vicosa, Brazil.; Hermsdorff, HHM (corresponding author), Univ Fed Vicosa, Dept Nutr & Hlth, Lab Clin Anal & Genom, Vicosa, Brazil.
EM helenhermana@ufv.br
RI Bressan, Josefina/A-2598-2009; Rocha, Daniela Mayumi/B-4255-2018
OI Rocha, Daniela Mayumi/0000-0001-6130-0179
FU Nacional de Desenvolvimento Cientifico fi co e Tecnoloygico y gico
   (CNPq) [428038/2018-2]; Nucleus of Microscopy and Microanalysis of the
   Universidade Federal de Viosa (UFV); Bioclin
FX This work was financed by the Coordenacao de Aperfeicoamento de Pessoal
   de Nivel Superior (CAPES, Code 001) , Fundacao de Amparo a Pesquisa do
   Estado de Minas Gerais (FAPEMIG, process CDS-APQ-00369-17) , and
   Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq,
   process 428038/2018-2) . JB and HHMH are CNPq fellows. This research was
   also supported by ECONUT (Amazon state, Brazil) which provided supplies
   (Brazil nuts) . The Nucleus of Microscopy and Microanalysis of the
   Universidade Federal de Vicosa (UFV) provided the facilities for the
   conduction of the experiments and data analysis. Bioclin
   (Quibasa-Quimica Basica Ltda) , through the project Projeto Brasil
   Escola, provided supplies for the biochemical dosages necessary to
   characterize the biochemical profiles of the study's participants.r
   Nacional de Desenvolvimento Cientifico fi co e Tecnoloygico y gico
   (CNPq, process 428038/2018-2) . JB and HHMH are CNPq fellows. This
   research was also supported by ECONUT (Amazon state, Brazil) which
   provided supplies (Brazil nuts) . The Nucleus of Microscopy and
   Microanalysis of the Universidade Federal de Vicosa (UFV) provided the
   facilities for the conduction of the experiments and data analysis.
   Bioclin (Quibasa-Quimica Baysica y sica Ltda) , through the project
   Projeto Brasil Escola, pro-vided supplies for the biochemical dosages
   necessary to characterize the biochemical profiles fi les of the study's
   participants.
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NR 64
TC 1
Z9 1
U1 0
U2 2
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0022-3166
EI 1541-6100
J9 J NUTR
JI J. Nutr.
PD SEP
PY 2024
VL 154
IS 9
BP 2670
EP 2679
DI 10.1016/j.tjnut.2024.07.016
EA SEP 2024
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA F3U4C
UT WOS:001309104100001
PM 39025334
DA 2025-06-11
ER

PT J
AU Rodríguez, JM
   Garranzo, M
   Segura, J
   Orgaz, B
   Arroyo, R
   Alba, C
   Beltrán, D
   Fernández, L
AF Rodriguez, Juan M.
   Garranzo, Marco
   Segura, Jose
   Orgaz, Belen
   Arroyo, Rebeca
   Alba, Claudio
   Beltran, David
   Fernandez, Leonides
TI A randomized pilot trial assessing the reduction of gout episodes in
   hyperuricemic patients by oral administration of Ligilactobacillus
   salivarius CECT 30632, a strain with the ability to degrade purines
SO FRONTIERS IN MICROBIOLOGY
LA English
DT Article
DE probiotics; Ligilactobacillus salivarius; gout; hyperuricemia; uric
   acid; inosine; guanosine
ID URIC-ACID; NUCLEOTIDE-METABOLISM; INFECTIOUS MASTITIS
AB IntroductionHyperuricemia and gout are receiving an increasing scientific and medical attention because of their relatively high prevalence and their association with relevant co-morbidities. Recently, it has been suggested that gout patients have an altered gut microbiota. The first objective of this study was to investigate the potential of some Ligilactobacillus salivarius strains to metabolize purine-related metabolites. The second objective was to evaluate the effect of administering a selected potential probiotic strain in individuals with a history of hyperuricemia. MethodsInosine, guanosine, hypoxanthine, guanine, xanthine, and uric acid were identified and quantified by high-performance liquid chromatography analysis. The uptake and biotransformation of these compounds by a selection of L. salivarius strains were assessed using bacterial whole cells and cell-free extracts, respectively. The efficacy of L. salivarius CECT 30632 to prevent gout was assessed in a pilot randomized controlled clinical trial involving 30 patients with hyperuricemia and a history of recurrent gout episodes. Half of the patients consumed L. salivarius CECT 30632 (9 log(10) CFU/day; probiotic group; n = 15) for 6 months while the remaining patients consumed allopurinol (100-300 mg/daily; control group; n = 15) for the same period. The clinical evolution and medical treatment received by the participants were followed, as well as the changes in several blood biochemical parameters. ResultsL. salivarius CECT 30632 was the most efficient strain for inosine (100%), guanosine (100%) and uric acid (50%) conversion and, therefore, it was selected for the pilot clinical trial. In comparison with the control group, administration of L. salivarius CECT 30632 resulted in a significant reduction in the number of gout episodes and in the use of gout-related drugs as well as an improvement in some blood parameters related to oxidative stress, liver damage or metabolic syndrome. ConclusionRegular administration of L. salivarius CECT 30632 reduced serum urate levels, the number of gout episodes and the pharmacological therapy required to control both hyperuricemia and gout episodes in individuals with a history of hyperuricemia and suffering from repeated episodes of gout.
C1 [Rodriguez, Juan M.; Arroyo, Rebeca; Alba, Claudio] Univ Complutense Madrid, Dept Nutr & Food Sci, Madrid, Spain.
   [Garranzo, Marco; Segura, Jose; Orgaz, Belen; Fernandez, Leonides] Univ Complutense Madrid, Dept Galen Pharm & Food Technol, Madrid, Spain.
   [Beltran, David] Ayuntamiento Madrid, Ctr Diagnost Med, Madrid, Spain.
C3 Complutense University of Madrid; Complutense University of Madrid
RP Rodríguez, JM (corresponding author), Univ Complutense Madrid, Dept Nutr & Food Sci, Madrid, Spain.; Fernández, L (corresponding author), Univ Complutense Madrid, Dept Galen Pharm & Food Technol, Madrid, Spain.
EM jmrodrig@ucm.es
RI Rodriguez, Juan/ABB-6650-2020; orgaz, belen/F-6454-2016; Fernández,
   Leonides/N-7521-2019; SEGURA PLAZA, JOSE FRANCISCO/P-4888-2019
OI Rodriguez, Juan/0000-0002-1285-9686; Alba, Claudio/0000-0003-0620-0313;
   SEGURA PLAZA, JOSE FRANCISCO/0000-0001-7090-7124
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NR 65
TC 15
Z9 15
U1 15
U2 50
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1664-302X
J9 FRONT MICROBIOL
JI Front. Microbiol.
PD FEB 14
PY 2023
VL 14
AR 1111652
DI 10.3389/fmicb.2023.1111652
PG 12
WC Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Microbiology
GA 9J0EH
UT WOS:000939871200001
PM 36865781
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Aminuddin, A
   Hashim, MFN
   Zaberi, NASM
   Wei, LZ
   Chu, BC
   Jamaludin, NA
   Salamt, N
   Roos, NAC
   Ugusman, A
AF Aminuddin, Amilia
   Noor Hashim, Muhammad Fakhrurrazi
   Mohd Zaberi, Nur Aina Syazana
   Zheng Wei, Lee
   Ching Chu, Beh
   Jamaludin, Nur Amalina
   Salamt, Norizam
   Che Roos, Nur Aishah
   Ugusman, Azizah
TI The Association Between Arterial Stiffness and Muscle Indices Among
   Healthy Subjects and Subjects With Cardiovascular Risk Factors: An
   Evidence-Based Review
SO FRONTIERS IN PHYSIOLOGY
LA English
DT Review
DE arterial stiffness; pulse wave velocity; muscle mass; muscle strength;
   muscle flexibility; cardiovascular
ID PULSE-WAVE VELOCITY; OXIDATIVE STRESS; NITRIC-OXIDE; AORTIC STIFFNESS;
   MICROVASCULAR FUNCTION; 1ST-DEGREE RELATIVES; INSULIN-RESISTANCE;
   METABOLIC SYNDROME; TRUNK FLEXIBILITY; DISEASE RISK
AB Skeletal muscle is one of the major tissues in the body and is important for performing daily physical activity. Previous studies suggest that vascular dysfunction contributes to reduced skeletal muscle mass. However, the association between vascular dysfunction and muscle mass, muscle strength and muscle flexibility are less established. Therefore, the focus of this review was to investigate the association between arterial stiffness (AS) which is a marker of vascular function, and muscle indices among healthy and those with cardiovascular risk factors. Three databases were used to search for relevant studies. These keywords were used: "arterial stiffness" OR "vascular stiffness" OR "aortic stiffness" OR "pulse wave velocity" OR "carotid femoral pulse wave velocity" OR "pulse wave analysis" AND "muscle" OR "skeletal" OR "flexibility" OR "range of motion" OR "articular" OR "arthrometry" OR "strength" OR "hand strength" OR "pinch strength" OR "mass" OR "lean" OR "body composition." The criteria were; (1) original, full-text articles, (2) articles written in English language, (3) human studies involving healthy adults and/or adults with cardiovascular disease (CVD) or CVD risk factors (4) articles that reported the relationship between AS (measured as carotid-femoral pulse wave velocity or brachial-ankle pulse wave velocity) and muscle indices (measured as muscle mass, muscle flexibility and muscle strength) after adjusting for relevant confounders. The search identified 2295 articles published between 1971 and June 2021. Only 17 articles fulfilled the criteria. Two studies showed an inverse association between AS and muscle strength in healthy subjects, whereas in subjects with CVD risk factors, five out of seven studies found an inverse correlation between the two parameters. Eleven studies showed an inverse association between AS and muscle mass in subjects with CVD and CVD risk factors. The association between AS and muscle flexibility was not studied in any of the articles reviewed. In conclusion, there is an inverse correlation between muscle indices and AS in healthy adults and those with CVD or CVD risk factors. However, most of the studies were cross-sectional studies, hence the need for future prospective studies to address this issue.
C1 [Aminuddin, Amilia; Noor Hashim, Muhammad Fakhrurrazi; Mohd Zaberi, Nur Aina Syazana; Zheng Wei, Lee; Ching Chu, Beh; Jamaludin, Nur Amalina; Salamt, Norizam; Ugusman, Azizah] Univ Kebangsaan Malaysia, Dept Physiol, Fac Med, Med Ctr, Cheras, Malaysia.
   [Che Roos, Nur Aishah] Natl Def Univ Malaysia, Fac Med & Def Hlth, Kem Sungai Besi, Malaysia.
C3 Universiti Kebangsaan Malaysia; Universiti Pertahanan Nasional Malaysia
RP Ugusman, A (corresponding author), Univ Kebangsaan Malaysia, Dept Physiol, Fac Med, Med Ctr, Cheras, Malaysia.
EM dr.azizah@ppukm.ukm.edu.my
RI Aminuddin, Amilia/AAC-5414-2020; Che Roos, Nur Aishah/ABE-4616-2021;
   Ugusman, Azizah/N-6731-2019
OI Aminuddin, Amilia/0000-0002-1329-0444; Che Roos, Nur
   Aishah/0000-0002-6497-5515; Ugusman, Azizah/0000-0001-8268-3316
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NR 63
TC 14
Z9 15
U1 0
U2 4
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1664-042X
J9 FRONT PHYSIOL
JI Front. Physiol.
PD NOV 23
PY 2021
VL 12
AR 742338
DI 10.3389/fphys.2021.742338
PG 13
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA XK7MU
UT WOS:000727645700001
PM 34887771
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Dongway, AC
   Faggad, AS
   Zaki, HY
   Abdalla, BE
AF Dongway, Angelo C.
   Faggad, Areeg S.
   Zaki, Hani Y.
   Abdalla, Badreldin E.
TI C-reactive protein is associated with low-density lipoprotein
   cholesterol and obesity in type 2 diabetic Sudanese
SO DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
LA English
DT Article
DE C-reactive protein; type 2 diabetes; lipid profile; obesity;
   cardiovascular disease; Sudanese
ID INFLAMMATORY MARKERS; OXIDATIVE STRESS; WAIST CIRCUMFERENCE; METABOLIC
   SYNDROME; CRP LEVELS; DYSLIPIDEMIA; MELLITUS; DISEASE; HEALTH;
   COMPLICATIONS
AB Background: Type 2 diabetes is emerging in Sudan and is associated with obesity. Deregulated lipid metabolism and inflammatory states are suggested risk factors for cardiovascular disease, which is a leading cause of diabetic death. This study aimed to investigate C-reactive protein (CRP) levels and the lipid profile in type 2 diabetic adult Sudanese compared with nondiabetics, and to test their associations with other characteristics.
   Methods: A cross-sectional study including 70 diabetics and 40 nondiabetics was conducted. Anthropometric measurements were assessed, and demographic and medical data were obtained using a structured questionnaire. Blood specimens were collected and biochemical parameters were analyzed applying standard methods.
   Results: CRP and triglycerides were significantly higher in the diabetic group (P<0.001 and P=0.01, respectively). Differences in total cholesterol, low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) were not statistically significant between the diabetic and nondiabetic groups. In the diabetic group, correlation analysis revealed that the CRP level had a significant positive correlation with LDL-C (r=0.255, P=0.034) and body mass index (r=0.29, P=0.016). Body mass index showed a significant positive correlation with triglycerides (r=0.386, P=0.001). Within the lipid parameters, a number of significant correlations were observed. Elevated levels of CRP, LDL-C, and triglycerides were markedly more prevalent in the diabetic group of patients. Diabetics showed significantly higher CRP levels compared with nondiabetics (odds ratio 5.56, P=0.001).
   Conclusion: The high prevalence of obesity among diabetics, together with elevated levels of triglycerides and CRP, suggest coexistence of dyslipidemia and inflammation in diabetes. Our findings emphasize that diabetics were 5.6 times more likely to have high CRP levels than nondiabetics; as CRP is a predictor of cardiovascular disease risk, it can be recognized that diabetics are at more risk of cardiovascular disease than nondiabetics. Considering evaluation of CRP together with the lipid profile in prediction of cardiovascular disease risk in Sudanese diabetics should be further tested in large-scale studies.
C1 [Dongway, Angelo C.] Upper Nile Univ, Dept Biochem, Fac Med, Malakal, South Sudan.
   [Faggad, Areeg S.; Zaki, Hani Y.; Abdalla, Badreldin E.] Univ Gezira, Fac Med, Dept Biochem & Nutr, Wad Madani, Sudan.
   [Faggad, Areeg S.] Univ Gezira, Natl Canc Inst, Dept Mol Biol, POB 20, Wad Madani, Sudan.
   [Abdalla, Badreldin E.] King Abdulaziz Univ, Fac Sci, Dept Biochem, Jeddah, Saudi Arabia.
C3 King Abdulaziz University
RP Faggad, AS (corresponding author), Univ Gezira, Natl Canc Inst, Dept Mol Biol, POB 20, Wad Madani, Sudan.
EM areegfaggad@hotmail.com
RI Faggad, Areeg/MVU-1608-2025
OI Zaki, Hani/0000-0001-8783-8073; Faggad, Areeg/0000-0003-1214-0046
FU Ministry of Education, Unity State, South Sudan
FX The authors are grateful to the study participants for their
   cooperation. The laboratory technicians at Abu Agla diabetes management
   center are acknowledged for their facilitation of the laboratory
   analyses. This work was funded by the Ministry of Education, Unity
   State, South Sudan.
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NR 60
TC 18
Z9 19
U1 0
U2 3
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-7007
J9 DIABET METAB SYND OB
JI Diabetes Metab. Syndr. Obes.
PY 2015
VL 8
BP 427
EP 435
DI 10.2147/DMSO.S85451
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA V06QL
UT WOS:000213954600046
PM 26379442
OA Green Submitted, gold, Green Published
DA 2025-06-11
ER

PT J
AU Aldana, SI
   Colicino, E
   Preciado, AC
   Tolentino, M
   Baccarelli, AA
   Wright, RO
   Rojo, MMT
   Valvi, D
AF Aldana, Sandra India
   Colicino, Elena
   Preciado, Alejandra Cantoral
   Tolentino, Maricruz
   Baccarelli, Andrea A.
   Wright, Robert O.
   Rojo, Martha Maria Tellez
   Valvi, Damaskini
TI Longitudinal associations between early-life fluoride exposures and
   cardiometabolic outcomes in school-aged children
SO ENVIRONMENT INTERNATIONAL
LA English
DT Article
DE Fluoride; Endocrine-disrupting chemicals; Cardiometabolic health;
   Obesity; Children
ID DRINKING-WATER; OXIDATIVE STRESS; INDUCED HEPATOTOXICITY; REPRODUCTIVE
   HORMONES; METABOLIC SYNDROME; DENTAL FLUOROSIS; PUBERTAL CHANGES;
   SODIUM-FLUORIDE; NATIONAL-HEALTH; BLOOD-PRESSURE
AB Background/Aim: Fluoride is a natural mineral present in food, water, and dental products, constituting ubiquitous long-term exposure in early childhood and across the lifespan. Experimental evidence shows fluoride -induced lipid disturbances with potential implications for cardiometabolic health. However, epidemiological studies are scarce. For the first time, we evaluated associations between repeated fluoride measures and cardiometabolic outcomes in children.
   Methods: We studied similar to 500 Mexican children from the Programming Research in Obesity, Growth, Environment and Social Stressors (PROGRESS) cohort with measurements on urinary fluoride at age 4, and dietary fluoride at ages 4, 6, and 8 years approximately. We used covariate-adjusted linear mixed-effects and linear regression models to assess fluoride associations with multiple cardiometabolic outcomes (ages 4-8): lipids (total cholesterol, HDL, LDL, and triglycerides), glucose, HbA1c, adipokines (leptin and adiponectin), body fat, and age-and sex-specific z-scores of body mass index (zBMI), waist circumference, and blood pressure.
   Results: Dietary fluoride intake at age 4 was associated with annual increases in triglycerides [beta per-fluoride -doubling = 2.02 (95 % CI: 0.37, 3.69)], cholesterol [beta = 1.46 (95 % CI: 0.52, 2.39)], HDL [beta = 0.39 (95 % CI: 0.02, 0.76)], LDL [beta = 0.87 (95 % CI: 0.02, 1.71)], and HbA1c [beta = 0.76 (95 % CI: 0.28, 1.24)], and decreased leptin [beta =-3.58 (95 % CI:-6.34,-0.75)] between the ages 4 and 8. In cross-sectional analyses at age 8, higher tertiles of fluoride exposure were associated with increases in zBMI, triglycerides, glucose, and leptin (p-tertile trend < 0.05). Stronger associations were observed in boys at year 8 and in girls prior to year 8 (p-sex interaction < 0.05). Fewer but consistent associations were observed for urinary fluoride at age 4, indicating increased annual changes in HDL and HbA1c with higher fluoride levels.
   Conclusion: Dietary fluoride exposures in early-and mid-childhood were associated with adverse cardiometabolic outcomes in school-aged children. Further research is needed to elucidate whether these associations persist at later ages.
C1 [Aldana, Sandra India; Colicino, Elena; Wright, Robert O.; Valvi, Damaskini] Icahn Sch Med Mt Sinai, Dept Environm Med & Publ Hlth, New York, NY USA.
   [Preciado, Alejandra Cantoral] Iberoamer Univ, Hlth Dept, Mexico City, Mexico.
   [Tolentino, Maricruz] Natl Inst Perinatol, Dept Nutr, Mexico City, Mexico.
   [Baccarelli, Andrea A.] Columbia Univ, Mailman Sch Publ Hlth, Dept Environm Hlth Sci, New York, NY USA.
   [Baccarelli, Andrea A.] Columbia Univ, Dept Epidemiol, Mailman Sch Publ Hlth, New York, NY USA.
   [Rojo, Martha Maria Tellez] Natl Inst Publ Hlth, Ctr Nutr & Hlth Res, Cuernavaca, Morelos, Mexico.
   [Aldana, Sandra India] Icahn Sch Med Mt Sinai, Ctr Adv Med, Dept Environm Med & Publ Hlth, 17 E 102nd St 3rd Fl, New York, NY 10029 USA.
C3 Icahn School of Medicine at Mount Sinai; Universidad Iberoamericana
   Ciudad de Mexico; Columbia University; Columbia University; Instituto
   Nacional de Salud Publica; Icahn School of Medicine at Mount Sinai
RP Aldana, SI (corresponding author), Icahn Sch Med Mt Sinai, Ctr Adv Med, Dept Environm Med & Publ Hlth, 17 E 102nd St 3rd Fl, New York, NY 10029 USA.
EM sandra.india-aldana@mssm.edu
RI Colicino, Elena/Q-4973-2016; Valvi, Dania/ABE-6650-2020
OI Valvi, Dania/0000-0003-4633-229X
FU National Institute of Environmental Health Sciences [R01ES033688,
   P30ES023515]
FX <BOLD>Funding</BOLD> This study was supported by grants from the
   National Institute of Environmental Health Sciences (R01ES033688 and
   P30ES023515) .
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NR 113
TC 5
Z9 5
U1 1
U2 4
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0160-4120
EI 1873-6750
J9 ENVIRON INT
JI Environ. Int.
PD JAN
PY 2024
VL 183
AR 108375
DI 10.1016/j.envint.2023.108375
EA DEC 2023
PG 13
WC Environmental Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology
GA FE3R0
UT WOS:001144051300001
PM 38128386
OA Green Accepted, gold
DA 2025-06-11
ER

PT J
AU Nederveen, JP
   Mastrolonardo, AJ
   Xhuti, D
   Di Carlo, A
   Manta, K
   Fuda, MR
   Tarnopolsky, MA
AF Nederveen, Joshua P.
   Mastrolonardo, Alexander J.
   Xhuti, Donald
   Di Carlo, Alessia
   Manta, Katherine
   Fuda, Matthew R.
   Tarnopolsky, Mark A.
TI Novel Multi-Ingredient Supplement Facilitates Weight Loss and Improves
   Body Composition in Overweight and Obese Individuals: A Randomized,
   Double-Blind, Placebo-Controlled Clinical Trial
SO NUTRIENTS
LA English
DT Article
DE nutraceutical; catechin; polyphenol; chlorogenic acids; biomarker;
   multi-ingredient supplement
ID FATTY LIVER-DISEASE; RESTING ENERGY-EXPENDITURE; ALPHA-LIPOIC ACID;
   GREEN TEA; METABOLIC SYNDROME; OXIDATIVE STRESS; WAIST CIRCUMFERENCE;
   INSULIN-RESISTANCE; VITAMIN-E; CATECHIN-POLYPHENOLS
AB Background: Despite the growing recognition of the obesity crisis, its rates continue to rise. The current first-line therapies, such as dietary changes, energy restriction, and physical activity, are typically met with poor adherence. Novel nutritional interventions can address the root causes of obesity, including mitochondrial dysfunction, and facilitate weight loss. Objective: The objective of this study was to investigate the effects of a multi-ingredient nutritional supplement designed to facilitate mitochondrial function and metabolic health outcomes over a 12 wk period. Methods: Fifty-five overweight and/or obese participants (age (mean +/- SEM): 26 +/- 1; body mass index (BMI) (kg/m(2)): 30.5 +/- 0.6) completed this double-blind, placebo-controlled clinical trial. Participants were randomized to 12 wks of daily consumption of multi-ingredient supplement (MIS; n = 28; containing 50 mg forskolin, 500 mg green coffee bean extract, 500 mg green tea extract, 500 mg beet root extract, 400 mg ff-lipoic acid, 200 IU vitamin E, and 200 mg CoQ10) or control placebo (PLA, n = 27; containing microcrystalline cellulose) matched in appearance. The co-primary outcomes were bodyweight and fat mass (kg) changes. The secondary outcomes included other body composition measures, plasma markers of obesity, fatty liver disease biomarkers, resting energy metabolism, blood pressure, physical performance, and quality of life. The post-intervention differences between MIS and PLA were examined via ANCOVA which was adjusted for the respective pre-intervention variables. Results: After adjustment for pre-intervention data, there was a significant difference in weight (p < 0.001) and fat mass (p < 0.001) post-intervention between the PLA and MIS treatment arms. Post-intervention weight and fat mass were significantly lower in MIS. Significant post-intervention differences corrected for baseline were found in markers of clinical biochemistry (AST, p = 0.017; ALT, p = 0.008), molecular metabolism (GDF15, p = 0.028), and extracellular vesicle-associated miRNA species miR-122 and miR-34a in MIS (p < 0.05). Conclusions: Following the 12 wks of MIS supplementation, weight and body composition significantly improved, concomitant with improvements in molecular markers of liver health and metabolism.
C1 [Nederveen, Joshua P.; Mastrolonardo, Alexander J.; Xhuti, Donald; Di Carlo, Alessia; Manta, Katherine; Fuda, Matthew R.; Tarnopolsky, Mark A.] McMaster Univ Med Ctr MUMC, Fac Hlth Sci, Dept Pediat, Hamilton, ON L8N 3Z5, Canada.
   [Tarnopolsky, Mark A.] McMaster Univ Med Ctr MUMC, Exerkine Corp, Hamilton, ON L8N 3Z5, Canada.
C3 McMaster University
RP Tarnopolsky, MA (corresponding author), McMaster Univ Med Ctr MUMC, Fac Hlth Sci, Dept Pediat, Hamilton, ON L8N 3Z5, Canada.; Tarnopolsky, MA (corresponding author), McMaster Univ Med Ctr MUMC, Exerkine Corp, Hamilton, ON L8N 3Z5, Canada.
EM nedervj@mcmaster.ca; tarnopol@mcmaster.ca
OI tarnopolsky, mark/0000-0003-0312-3746
FU The authors would like to thank the Hamilton Regional Laboratory
   Medicine Program-McMaster Site Core Laboratory for their assistance in
   clinical blood analysis. We would like to thank Mahek Minhas for her
   technical assistance. Data are available upon reaso
FX The authors would like to thank the Hamilton Regional Laboratory
   Medicine Program-McMaster Site Core Laboratory for their assistance in
   clinical blood analysis. We would like to thank Mahek Minhas for her
   technical assistance. Data are available upon reasonable request to the
   corresponding author. Figures were created with Biorender.
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NR 157
TC 10
Z9 10
U1 3
U2 16
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD SEP
PY 2023
VL 15
IS 17
AR 3693
DI 10.3390/nu15173693
PG 26
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA S3GP6
UT WOS:001070090200001
PM 37686725
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Srivastava, S
   Virmani, T
   Haque, MR
   Alhalmi, A
   Al Kamaly, O
   Alshawwa, SZ
   Nasr, FA
AF Srivastava, Swati
   Virmani, Tarun
   Haque, Md. Rafiul
   Alhalmi, Abdulsalam
   Al Kamaly, Omkulthom
   Alshawwa, Samar Zuhair
   Nasr, Fahd A. A.
TI Extraction, HPTLC Analysis and Antiobesity Activity of Jatropha
   tanjorensis and Fraxinus micrantha on High-Fat Diet Model in
   Rats
SO LIFE-BASEL
LA English
DT Article
DE Jatropha tanjorensis; Fraxinus micrantha; HPTLC; anti-obesity activity;
   high-fat diet model; histological
ID BIOACTIVE COMPOUNDS; OBESITY; ANTIOXIDANT; TOXICITY; LEAVES
AB The accumulation of body fat due to an imbalance between calorie intake and energy expenditure is called obesity. Metabolic syndrome increases the risk of heart disease, type 2 diabetes, and stroke. The purpose of this study was to determine the effect of Jatropha tanjorensis (J.T.) and Fraxinus micrantha (F.M.) leaf extracts on high-fat diet-induced obesity in rats. Normal control, high-fat diet (HFD) control, orlistat standard, and test groups were created using male Albino Wistar rats (n = 6 per group) weighing 190 & PLUSMN; 15 g. Except for the control group, all regimens were administered orally and continued for 6 weeks while on HFD. Evaluation criteria included body weight, food intake, blood glucose, lipid profile, oxidative stress, and liver histology. High-Performance Thin Layer Chromatography (HPTLC) analysis was performed using a solvent system (7:3 hexane: ethyl acetate for sitosterol solution and Jatropha tanjorensis extracts and 6:4 hexane: ethyl acetate: 1 drop of acetic acid for esculetin and Fraxinus micrantha extracts). There were no deaths during the 14 days before the acute toxicity test, indicating that aqueous and ethanolic extracts of both J.T. and F.M. did not produce acute toxicity at any dose (5, 50, 300, and 2000 mg/kg). The ethanolic and aqueous extracts of J.T. and F.M. leaves at 200 and 400 mg/kg/orally showed a reduction in weight gain, feed intake, and significant decreases in serum glucose and lipid profile. As compared to inducer HFD animals, co-treatment of aqueous and ethanolic extract of both J.T. and F.M. and orlistat increased the levels of antioxidant enzymes and decreased lipid peroxidation. The liver's histological findings showed that the sample had some degree of protection. These results indicate that ethanolic samples of J.T. have antidiabetic potential in diabetic rats fed an HFD. The strong antioxidant potential and restoration of serum lipid levels may be related to this. Co-treatment of samples JTE, JTAQ, FME, FMAQ and orlistat resulted in an increase in antioxidant enzymes and reduction in lipid peroxidation as compared to inducer HFD animals. We report, for the first time, on using these leaves to combat obesity.
C1 [Srivastava, Swati; Virmani, Tarun] MVN Univ, Sch Pharmaceut Sci, Palwal 121105, India.
   [Haque, Md. Rafiul] Al Karim Univ, Sch Pharm, Katihar 854106, India.
   [Alhalmi, Abdulsalam] Aden Univ, Coll Pharm, Dept Pharmaceut Sci, Aden 6312, Yemen.
   [Al Kamaly, Omkulthom; Alshawwa, Samar Zuhair] Princess Nourah Bint Abdulrahman Univ, Coll Pharm, Dept Pharmaceut Sci, POB 84428, Riyadh 11671, Saudi Arabia.
   [Nasr, Fahd A. A.] King Saud Univ, Coll Pharm, Dept Pharmacognosy, Riyadh 11451, Saudi Arabia.
C3 Princess Nourah bint Abdulrahman University; King Saud University
RP Virmani, T (corresponding author), MVN Univ, Sch Pharmaceut Sci, Palwal 121105, India.
EM swatisrivastva186@gmail.com; tarun.virmani@mvn.edu.in;
   hrafiul@gmail.com; omalkmali@pnu.edu.sa; szalshawwa@pnu.edu.sa;
   fnasr@ksu.edu.sa
RI Alhalmi, Abdulsalam/AAV-8724-2020; VIRMANI, TARUN/AAB-5648-2021;
   Srivastava, Swati/JNS-8266-2023; Nasr, Fahd/ABG-5258-2020; Al kamaly,
   Omkulthom/AFV-8845-2022; Alshawwa, Samar/AGO-8238-2022
OI Nasr, Fahd A/0000-0002-6496-7822; Alhalmi,
   Abdulsalam/0000-0001-7985-4241; Alshawwa, Samar/0000-0001-9232-7956;
   VIRMANI, TARUN/0000-0002-1615-5213; Al kamaly,
   Omkulthom/0000-0003-4706-4311; Srivastava, Swati/0009-0004-0605-7355
FU Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia
   [PNURSP2023R165]
FX This research was funded by Princess Nourah bint Abdulrahman University
   Researchers Supporting Project number (PNURSP2023R165), Princess Nourah
   bint Abdulrahman University, Riyadh, Saudi Arabia.
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NR 38
TC 3
Z9 3
U1 0
U2 4
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2075-1729
J9 LIFE-BASEL
JI Life-Basel
PD JUN
PY 2023
VL 13
IS 6
AR 1248
DI 10.3390/life13061248
PG 14
WC Biology; Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics; Microbiology
GA K6FZ3
UT WOS:001017390600001
PM 37374031
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Aleliunas, RE
   Aljaadi, AM
   Laher, I
   Glier, MB
   Green, TJ
   Murphy, M
   Miller, JW
   Devlin, AM
AF Aleliunas, Rika E.
   Aljaadi, Abeer M.
   Laher, Ismail
   Glier, Melissa B.
   Green, Tim J.
   Murphy, Melissa
   Miller, Joshua W.
   Devlin, Angela M.
TI Folic Acid Supplementation of Female Mice, with or without Vitamin B-12,
   before and during Pregnancy and Lactation Programs Adiposity and
   Vascular Health in Adult Male Offspring
SO JOURNAL OF NUTRITION
LA English
DT Article
DE developmental programming; vitamin B-12; folate; adiposity; glucose
   intolerance
ID HIGH-FAT DIET; IMPROVES ENDOTHELIAL FUNCTION; INSULIN-RESISTANCE;
   DIHYDROFOLATE-REDUCTASE; FOLATE CONCENTRATIONS; METABOLIC SYNDROME;
   OXIDATIVE STRESS; NATIONAL-HEALTH; INDUCED OBESITY; UNITED-STATES
AB Background: The developmental origins of health and disease theory suggest that disturbances in the fetal and early postnatal environment contribute to chronic adulthood diseases, such as type 2 diabetes and cardiovascular disease. Greater adiposity and insulin resistance have been reported in children of women with high erythrocyte folate but poor vitamin B-12 status during pregnancy. The mechanisms underlying this relation are not known.
   Objective: The objective of this study was to investigate the effects of maternal supplemental folic acid, with or without vitamin B-12, on adiposity, glucose homeostasis, and vascular health in adult male offspring mice.
   Methods: Female C57BL/6J mice were fed a control diet (M-CON, 2 mg folic acid/kg, 50 mg vitamin B-12/kg) or a folic acid-supplemented diet with [10 mg folic acid/kg, 50 mg vitamin B-12/kg (SFA+B12)] or without [10 mg folic acid/kg, no vitamin B-12 (SFA-B12)] vitamin B-12 for 6 wk before mating and during pregnancy and lactation. The offspring were weaned onto a control diet (16% energy from fat) or a western diet (45% energy from fat) until 23 wk of age. The effects of maternal diet on adiposity, vascular function, and glucose tolerance were assessed in 6 groups of adult male offspring: control diet-fed M-CON, SFA+B12, and SFA-B12 and western diet-fed M-CON, SFA+B12, and SFA-B12.
   Results: Control and western diet-fed SFA-B12 and SFA+B12 offspring had smaller visceral and subcutaneous adipose tissue than M-CON offspring (P < 0.05). Control SFA-B12 and SFA+B12 offspring had lower serum total adiponectin and vitamin B-12 concentrations and lower NADPH oxidase 2 expression in aorta compared with M-CON offspring (P < 0.05). These effects were not observed in western diet-fed offspring.
   Conclusions: Folic acid supplementation of female mice before and during pregnancy and lactation, with or without dietary vitamin B-12, affects adult male offspring adiposity, vascular function, and one-carbon metabolism in those fed a control diet but not a western diet.
C1 [Aleliunas, Rika E.; Glier, Melissa B.; Devlin, Angela M.] Univ British Columbia, Child & Family Res Inst, Dept Pathol & Lab Med, Vancouver, BC, Canada.
   [Aljaadi, Abeer M.; Green, Tim J.] Univ British Columbia, Child & Family Res Inst, Dept Food Nutr & Hlth, Vancouver, BC, Canada.
   [Laher, Ismail] Univ British Columbia, Child & Family Res Inst, Dept Anesthesiol Pharmacol & Therapeut, Vancouver, BC, Canada.
   [Devlin, Angela M.] Univ British Columbia, Dept Pediat, Child & Family Res Inst, Vancouver, BC V6T 1W5, Canada.
   [Murphy, Melissa; Miller, Joshua W.] Rutgers State Univ, Dept Nutr Sci, New Brunswick, NJ 08903 USA.
   [Green, Tim J.] South Australian Hlth & Med Res Inst, Adelaide, SA, Australia.
   [Green, Tim J.] Womens & Childrens Hlth Res Inst, Adelaide, SA, Australia.
C3 University of British Columbia; Child & Family Research Institute; Child
   & Family Research Institute; University of British Columbia; Child &
   Family Research Institute; University of British Columbia; University of
   British Columbia; Child & Family Research Institute; Rutgers University
   System; Rutgers University New Brunswick; South Australian Health &
   Medical Research Institute (SAHMRI); Women's & Children's Health
   Research Institute; Women's & Children's Hospital
RP Devlin, AM (corresponding author), Univ British Columbia, Child & Family Res Inst, Dept Pathol & Lab Med, Vancouver, BC, Canada.; Devlin, AM (corresponding author), Univ British Columbia, Dept Pediat, Child & Family Res Inst, Vancouver, BC V6T 1W5, Canada.
EM adevlin@cfri.ubc.ca
RI Green, Tim/AAA-8601-2019; Laher, Ismail/X-3323-2019; Aljaadi,
   Abeer/GQO-9845-2022
OI Green, Timothy/0000-0002-0667-4300; Devlin, Angela/0000-0002-1390-6587;
   Laher, Ismail/0000-0002-3917-4417; Aljaadi, Abeer/0000-0003-4646-9210;
   Glier, Melissa/0000-0003-3723-3177
FU Natural Sciences and Engineering Council of Canada Discovery Grant
   [RGPGP-2014-00066]; Canadian Institutes for Health Research
   [MOP-133399]; Child and Family Research Institute; University of British
   Columbia; Umm Al Qura University
FX Supported by the Natural Sciences and Engineering Council of Canada
   Discovery Grant RGPGP-2014-00066 (to AMD) and Canadian Institutes for
   Health Research operating grant MOP-133399 (to IL and AMD). AMD is
   supported by an investigator award from the Child and Family Research
   Institute. MBG is supported by a doctoral fellowship from the University
   of British Columbia. AMA is supported by a scholarship from Umm Al Qura
   University administered by the Saudi Arabian Cultural Bureau in Canada.
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NR 49
TC 23
Z9 22
U1 0
U2 17
PU AMER SOC NUTRITION-ASN
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-3166
EI 1541-6100
J9 J NUTR
JI J. Nutr.
PD APR
PY 2016
VL 146
IS 4
BP 688
EP 696
DI 10.3945/jn.115.227629
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA DI3RA
UT WOS:000373415000005
PM 26962174
OA Bronze
DA 2025-06-11
ER

PT J
AU Scheen, AJ
   Esser, N
   Paquot, N
AF Scheen, A. J.
   Esser, N.
   Paquot, N.
TI Antidiabetic agents: Potential anti-inflammatory activity beyond glucose
   control
SO DIABETES & METABOLISM
LA English
DT Review
DE Inflammation; Gliptin; GLP-1 receptor agonist; Metformin;
   Thiazolidinedione; Type 2 diabetes mellitus
ID POLYCYSTIC-OVARY-SYNDROME; DIPEPTIDYL PEPTIDASE-4 INHIBITOR; ACTIVATED
   PROTEIN-KINASE; TYPE-2 DIABETIC-PATIENTS; CARDIOVASCULAR RISK-FACTORS;
   FACTOR-KAPPA-B; OXIDATIVE STRESS; INSULIN THERAPY; ENDOTHELIAL
   DYSFUNCTION; INFLAMMATORY MARKERS
AB A growing body of evidence is emerging to show that abdominal obesity, the metabolic syndrome, type 2 diabetes, cardiovascular disease and microvascular diabetic complications are intimately related to chronic inflammation. These observations pave the way to the development of new pharmacological strategies that aim to reduce silent inflammation. However, besides specific anti-inflammatory agents, glucose-lowering medications may also exert anti-inflammatory effects that could contribute to improved outcomes in diabetic patients. Most studies have used metformin, an AMP-activated protein kinase (AMPK) activator, and thiazolidinediones (TZDs), which act as peroxisome proliferator-activated receptor-gamma (PPAR gamma) agonists. Both pharmacological classes (considered insulin-sparing agents or insulin sensitizers) appear to have greater anti-inflammatory activity than insulin-secreting agents such as sulphonylureas or glinides. In particular, TZDs have shown the widest range of evidence of lowered tissue (visceral fat and liver) and serum inflammation. In contrast, despite reducing postprandial hyperglycaemia, the effect of a-glucosidase inhibitors on inflammatory markers appears rather modest, whereas dipeptidyl peptidase-4 (DPP-4) inhibitors (gliptins) and glucagon-like peptide-1 (GLP-1) receptor agonists appear more promising in this respect. These incretin-based therapies exert pleiotropic effects, including reports of anti-inflammatory activity. No human data are available so far regarding sodium-glucose cotransporter type 2 (SGLT2) inhibitors. Although they may have indirect effects due to reduced glucotoxicity, their specific mode of action in the kidneys does not suggest systemic anti-inflammatory activity. Also, in spite of the complex relationship between insulin and atherosclerosis, exogenous insulin may also exert anti-inflammatory effects. Nevertheless, for all these glucose-lowering agents, it is essential to distinguish between anti-inflammatory effects resulting from better glucose control and potential anti-inflammatory effects related to intrinsic actions of the pharmacological class. Finally, it would also be of major clinical interest to define what role the anti-inflammatory effects of these glucose-lowering agents may play in the prevention of macrovascular and microvascular diabetic complications. (C) 2015 Published by Elsevier Masson SAS.
C1 [Scheen, A. J.] Univ Liege, CIRM, Clin Pharmacol Unit, B-4000 Liege 1, Belgium.
   [Scheen, A. J.] CHU Sart Tilman, CHU Liege, Dept Med, Div Diabet Nutr & Metab Disorders, B-4000 Liege 1, Belgium.
   [Esser, N.; Paquot, N.] Univ Liege, GIGA 13, Diabetol & Nutr Unit, B-4000 Liege 1, Belgium.
   [Esser, N.; Paquot, N.] CHU Liege, Dept Med, Div Diabet Nutr & Metab Disorders, Liege, Belgium.
C3 University of Liege; University of Liege; University of Liege;
   University of Liege
RP Scheen, AJ (corresponding author), CHU Sart Tilman, Dept Med, B35, B-4000 Liege 1, Belgium.
EM andre.scheen@chu.ulg.ac.be
FU AstraZeneca/BMS; Boehringer Ingelheim; Eli Lilly; Glaxo-SmithKline;
   Janssen; Merck Sharp Dohme; Novartis; Novo Nordisk; Sanofi; Takeda
FX A.J. Scheen has received lecture/advisor fees from AstraZeneca/BMS,
   Boehringer Ingelheim, Eli Lilly, Glaxo-SmithKline, Janssen, Merck Sharp
   & Dohme, Novartis, Novo Nordisk, Sanofi and Takeda.N. Paquot has
   received lecturer fees from Merck Sharp & Dohme and Novo Nordisk.
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NR 141
TC 121
Z9 130
U1 1
U2 50
PU MASSON EDITEUR
PI MOULINEAUX CEDEX 9
PA 21 STREET CAMILLE DESMOULINS, ISSY, 92789 MOULINEAUX CEDEX 9, FRANCE
SN 1262-3636
EI 1878-1780
J9 DIABETES METAB
JI Diabetes Metab.
PD JUN
PY 2015
VL 41
IS 3
BP 183
EP 194
DI 10.1016/j.diabet.2015.02.003
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA CL8TT
UT WOS:000357247700002
PM 25794703
DA 2025-06-11
ER

PT J
AU Marycz, K
   Wiatrak, B
   Irwin-Houston, JM
   Marcinkowska, K
   Mularczyk, M
   Bourebaba, L
AF Marycz, Krzysztof
   Wiatrak, Benita
   Irwin-Houston, Jennifer M.
   Marcinkowska, Klaudia
   Mularczyk, Malwina
   Bourebaba, Lynda
TI Sex hormone binding globulin (SHBG) modulates mitochondrial dynamics in
   PPARγ-depleted equine adipose derived stromal cells
SO JOURNAL OF MOLECULAR MEDICINE-JMM
LA English
DT Article
DE PPAR gamma; SHBG; Equine ASCs; Metabolic syndrome; Mitochondria;
   Senescence
ID PROLIFERATOR-ACTIVATED RECEPTOR; INSULIN-SENSITIVITY; STEM-CELLS;
   APOPTOSIS; INHIBITION; PATHOPHYSIOLOGY; DYSFUNCTION; BIOGENESIS;
   RESISTANCE; SURVIVAL
AB Peroxisome proliferator-activated receptor gamma (PPAR gamma) is a transcription factor that promotes adipogenesis, lipid uptake and storage, insulin sensitivity, and glucose metabolism. Hence, defects in PPAR gamma have been associated to the development of metabolic disorders. Sex hormone-binding globulin (SHBG) is a glycoprotein primarily produced in the liver that regulates the bioavailability of sex hormones. Alike PPAR gamma, low SHBG levels have been correlated with insulin resistance and associated endocrine abnormalities. Therefore, this study aimed to verify whether SHBG may restore depleted PPAR gamma functions and thus serve as a new candidate for the management of metabolic conditions. A model of equine adipose-derived stromal cells (EqASCs) has been used, in which a PPAR gamma silencing and SHBG treatment have been achieved to determine the changes in cell viability, premature senescence, oxidative stress, and mitochondrial functions. Obtained data demonstrated that loss in PPAR gamma triggers cell apoptosis which is not reversed by SHBG application. Moreover, PPAR gamma knockdown cells exhibited premature senescence, which has been substantially alleviated by SHBG concomitantly to increased BAX/BCL2 ratio, suggesting a possible effect on senescence-induced apoptosis resistance. Interestingly, PPAR gamma silencing induced a significant alteration in mitochondrial membrane potential as well as the expression of dynamics and metabolism-related markers. SHBG treatment enabled to ameliorate the transmembrane potential, to normalize the expression levels of key dynamics and metabolism mediators, and to restore the protein levels of PINK, which is critically involved in mitochondria recycling machinery. Presented data suggest that SHBG may provide new mechanistic insights into the regulation of PPAR gamma functions, and thus offers a preliminary picture on a possible SHBG-PPAR gamma metabolic crosstalk.
   Key messages
   PPAR gamma is a transcription factor that tightly regulates cell metabolism.
   Low SHBG levels correlate with insulin resistance and associated endocrine abnormalities.
   PPAR gamma silencing reduces cell viability, triggers premature senescence and profound mitochondrial failure in equine ASCs.
   SHBG protein reverses senescent phenotype and apoptosis resistance of PPAR gamma- ASCs.
   SHBG improves mitochondrial dynamics and metabolism following PPAR gamma knockdown.
   SHBG might serve as a PPAR gamma potential mimicking agent for the modulation of ASCs metabolic processes.
C1 [Marycz, Krzysztof; Wiatrak, Benita; Irwin-Houston, Jennifer M.; Marcinkowska, Klaudia; Mularczyk, Malwina; Bourebaba, Lynda] Wrocaw Univ Environm & Life Sci, Fac Biol & Anim Sci, Dept Expt Biol, PL-50375 Wroclaw, Poland.
   [Marycz, Krzysztof; Mularczyk, Malwina] Int Inst Translat Med, Jesionowa 11, PL-55114 Malin, Wisznia Mala, Poland.
   [Marycz, Krzysztof] Univ Calif Davis, Sch Vet Med, Dept Med & Epidemiol, Davis, CA 95516 USA.
C3 Wroclaw University of Environmental & Life Sciences; University of
   California System; University of California Davis
RP Bourebaba, L (corresponding author), Wrocaw Univ Environm & Life Sci, Fac Biol & Anim Sci, Dept Expt Biol, PL-50375 Wroclaw, Poland.
EM lynda.bourebaba@upwr.edu.pl
RI Wiatrak, Benita/T-3402-2018; Marycz, Krzysztof/A-2249-2017; Bourebaba,
   Lynda/AAX-7613-2020
FU National Science Centre in Poland [2019/35/B/NZ7/03651]; Wroclaw
   University of Environmental and Life Sciences
FX The work was supported by a research grant financed by the National
   Science Centre in Poland over the course of the realization of the
   project: "Exploring the role and therapeutic potential of sex hormone
   binding globulin (SHBG) in the course of insulin resistance,
   inflammation, lipotoxicity in adipose stem progenitor cells and
   adipocytes in equine metabolic syndrome (EMS) mares" (No 2019/35/B/
   NZ7/03651). The APC was co-financed by Wroclaw University of
   Environmental and Life Sciences.
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NR 67
TC 2
Z9 2
U1 3
U2 6
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0946-2716
EI 1432-1440
J9 J MOL MED
JI J. Mol. Med.
PD AUG
PY 2024
VL 102
IS 8
BP 1015
EP 1036
DI 10.1007/s00109-024-02459-z
EA JUN 2024
PG 22
WC Genetics & Heredity; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Genetics & Heredity; Research & Experimental Medicine
GA L4J6X
UT WOS:001246514000001
PM 38874666
OA hybrid
DA 2025-06-11
ER

PT J
AU Ho, KC
   Gupta, P
   Fenwick, EK
   Man, REK
   Gan, ATL
   Lamoureux, EL
AF Ho, Kam Chun
   Gupta, Preeti
   Fenwick, Eva K.
   Man, Ryan E. K.
   Gan, Alfred T. L.
   Lamoureux, Ecosse L.
TI Association between age-related sensory impairment with sarcopenia and
   its related components in older adults: a systematic review
SO JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
LA English
DT Review
DE Sarcopenia; Sensory impairment; Visual impairment; Hearing impairment;
   Taste impairment; Smell impairment
ID SARC-F QUESTIONNAIRE; OXIDATIVE STRESS; PHYSICAL-ACTIVITY; HEARING
   IMPAIRMENT; METABOLIC SYNDROME; COST-EFFECTIVENESS; GAIT SPEED;
   COMMUNITY; RISK; PREVALENCE
AB Sensory impairments and sarcopenia are both highly prevalent age-related conditions, with the former having been postulated to contribute to the pathogenesis of the latter condition. Confirming this hypothesis may therefore help to better inform strategies for early treatment and intervention of sarcopenia. We performed a systematic review of the current literature examining the relationships between four major sensory impairments [vision (VI), hearing (HI), smell (SI), and taste (TI)] with (i) sarcopenia; and (ii) its associated components (low handgrip strength, slow gait speed, and low muscle mass). PubMed, EMBASE, CINAHL, and Cochrane Library databases were searched for observational studies investigating the relationship of VI, HI, SI, and TI with sarcopenia, low handgrip strength, slow gait speed, and low muscle mass, in adults aged 50 years or older, from inception until 24 May 2021. The risk of bias of the included studies was assessed using the Newcastle-Ottawa Scale. This study was registered with PROSPERO, reference CRD42021247967. Ten cross-sectional and three longitudinal population-based studies of community-dwelling adults (N = 68 235) were included, with five studies investigating more than one sensory impairment. In total, 8, 6, 3, and 1 studies investigated the relationship between VI, HI, SI, and TI and sarcopenia and its related components, respectively. Follow-up duration for the longitudinal studies ranged from 4 to 11 years. All studies had a low or moderate risk of bias. We found that the presence of VI and SI, but not TI, independently increased the odds of sarcopenia. In addition, VI and SI were each independently associated with low muscle mass; and VI, HI, and SI were each independently associated with slow gait speed. However, we found inconclusive evidence for the associations between VI, HI and SI, and low handgrip strength. Our systematic review suggests a potential association between the presence of single or multiple sensory impairments and a greater likelihood of sarcopenia and/or deficits in its associated components, especially for VI, HI, and SI. Prospective studies are needed to untangle the relationship between sensory impairment and sarcopenia to better inform clinical guidelines for disease prevention and management.
C1 [Ho, Kam Chun; Gupta, Preeti; Fenwick, Eva K.; Man, Ryan E. K.; Gan, Alfred T. L.; Lamoureux, Ecosse L.] Singapore Eye Res Inst SERI, Singapore Natl Eye Ctr, 20 Coll Rd,Level 6, Singapore, Singapore.
   [Ho, Kam Chun] Univ Canberra, Fac Hlth, Discipline Optometry & Vis Sci, Canberra, ACT, Australia.
   [Ho, Kam Chun] UNSW Sydney, Fac Med & Hlth, Sch Optometry & Vis Sci, Sydney, NSW, Australia.
   [Gupta, Preeti; Fenwick, Eva K.; Man, Ryan E. K.; Lamoureux, Ecosse L.] Duke NUS Med Sch, Singapore, Singapore.
   [Lamoureux, Ecosse L.] Natl Univ Singapore, Dept Ophthalmol, Singapore, Singapore.
   [Lamoureux, Ecosse L.] Univ Melbourne, Dept Surg & Med, Melbourne, Vic, Australia.
C3 Singapore National Eye Center; University of Canberra; University of New
   South Wales Sydney; National University of Singapore; National
   University of Singapore; University of Melbourne
RP Lamoureux, EL (corresponding author), Singapore Eye Res Inst SERI, Singapore Natl Eye Ctr, 20 Coll Rd,Level 6, Singapore, Singapore.
EM ecosse.lamoureux@duke-nus.edu.sg
RI Lamoureux, Ecosse/Z-5482-2019; Ho, Kam Chun/AAX-9509-2021
OI Ho, Kam Chun/0000-0001-9029-4329; Lamoureux, Ecosse/0000-0001-8674-5705;
   Fenwick, Eva/0000-0003-0417-2048; Man, Ryan/0000-0001-5028-605X
FU National Medical Research Council Senior Clinician Scientist Award
   (NMRC-CSA-SI) [JRNMRR140601]; NMRC Transition Award [MOH-TA19may-0002]
FX Professor Lamoureux is supported by the National Medical Research
   Council Senior Clinician Scientist Award (NMRC-CSA-SI #JRNMRR140601).
   Asst. Prof. Man is supported by the NMRC Transition Award
   (#MOH-TA19may-0002). The funding organizations had no role in the design
   or conduct of this research or preparation of this manuscript. The
   authors of this manuscript certify that they comply with the ethical
   guidelines for authorship and publishing in the Journal of Cachexia,
   Sarcopenia and Muscle.<SUP>72</SUP</SUP>
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NR 72
TC 11
Z9 11
U1 0
U2 22
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2190-5991
EI 2190-6009
J9 J CACHEXIA SARCOPENI
JI J. Cachexia Sarcopenia Muscle
PD APR
PY 2022
VL 13
IS 2
BP 811
EP 823
DI 10.1002/jcsm.12930
EA MAR 2022
PG 13
WC Geriatrics & Gerontology; Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; General & Internal Medicine
GA 0K6NM
UT WOS:000762253700001
PM 35229470
OA Green Published
DA 2025-06-11
ER

PT J
AU Maissan, P
   Mooij, EJ
   Barberis, M
AF Maissan, Parcival
   Mooij, Eva J.
   Barberis, Matteo
TI Sirtuins-Mediated System-Level Regulation of Mammalian Tissues at the
   Interface between Metabolism and Cell Cycle: A Systematic Review
SO BIOLOGY-BASEL
LA English
DT Review
DE Sirtuins; metabolic disorders; metabolic syndrome; cell cycle; pancreas;
   liver; brain; adipose tissue; muscle; heart
ID PROLIFERATOR-ACTIVATED-RECEPTOR; HIGH-FAT DIET; PANCREATIC BETA-CELLS;
   FOXO TRANSCRIPTION FACTORS; STIMULATED INSULIN-SECRETION; MESSENGER-RNA
   EXPRESSION; HEPATIC LIPID-METABOLISM; TUMOR-SUPPRESSOR PROTEIN;
   SKELETAL-MUSCLE SIRT1; WHITE ADIPOSE-TISSUE
AB Simple Summary
   A vast number of molecules are involved in regulating metabolism in mammals. Among these molecules, Sirtuins play pivotal roles in the regulation of metabolism. Sirtuins are a family of seven members that are expressed in several tissues/organs and connect the inner and outer environment of the mammalian body to ensure a proper balance of metabolic activities. Deregulation of Sirtuins can be involved in a disturbed balance that is found in metabolic diseases such as obesity and cancer. The level and function of Sirtuins differ per tissue/organ and among mammals and shall be taken into account when envisioning administration of drugs that may affect Sirtuin activity. This systematic review provides an overview of the function of Sirtuins in six metabolic tissues/organs, and of the relevant processes that they regulate. Both healthy and metabolic disease conditions are discussed.
   Sirtuins are a family of highly conserved NAD+-dependent proteins and this dependency links Sirtuins directly to metabolism. Sirtuins' activity has been shown to extend the lifespan of several organisms and mainly through the post-translational modification of their many target proteins, with deacetylation being the most common modification. The seven mammalian Sirtuins, SIRT1 through SIRT7, have been implicated in regulating physiological responses to metabolism and stress by acting as nutrient sensors, linking environmental and nutrient signals to mammalian metabolic homeostasis. Furthermore, mammalian Sirtuins have been implicated in playing major roles in mammalian pathophysiological conditions such as inflammation, obesity and cancer. Mammalian Sirtuins are expressed heterogeneously among different organs and tissues, and the same holds true for their substrates. Thus, the function of mammalian Sirtuins together with their substrates is expected to vary among tissues. Any therapy depending on Sirtuins could therefore have different local as well as systemic effects. Here, an introduction to processes relevant for the actions of Sirtuins, such as metabolism and cell cycle, will be followed by reasoning on the system-level function of Sirtuins and their substrates in different mammalian tissues. Their involvement in the healthy metabolism and metabolic disorders will be reviewed and critically discussed.
C1 [Maissan, Parcival; Barberis, Matteo] Univ Amsterdam, Swammerdam Inst Life Sci, Synthet Syst Biol & Nucl Org, NL-1098 XH Amsterdam, Netherlands.
   [Mooij, Eva J.; Barberis, Matteo] Univ Surrey, Fac Hlth & Med Sci, Sch Biosci & Med, Syst Biol, Guildford GU2 7XH, Surrey, England.
   [Mooij, Eva J.; Barberis, Matteo] Univ Surrey, Ctr Math & Computat Biol, CMCB, Guildford GU2 7XH, Surrey, England.
C3 University of Amsterdam; University of Surrey; University of Surrey
RP Barberis, M (corresponding author), Univ Amsterdam, Swammerdam Inst Life Sci, Synthet Syst Biol & Nucl Org, NL-1098 XH Amsterdam, Netherlands.; Barberis, M (corresponding author), Univ Surrey, Fac Hlth & Med Sci, Sch Biosci & Med, Syst Biol, Guildford GU2 7XH, Surrey, England.; Barberis, M (corresponding author), Univ Surrey, Ctr Math & Computat Biol, CMCB, Guildford GU2 7XH, Surrey, England.
EM p.maissan@uva.nl; e.mooij@surrey.ac.uk; matteo@barberislab.com
RI Barberis, Matteo/JNE-9357-2023
OI Mooij, Eva/0000-0003-4316-8949; Maissan, Parcival/0009-0009-6961-7109;
   Barberis, Matteo/0000-0001-5640-7422
FU Systems Biology Grant of the University of Surrey
FX This research was funded by the Systems Biology Grant of the University
   of Surrey to M.B.
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NR 709
TC 30
Z9 31
U1 3
U2 38
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2079-7737
J9 BIOLOGY-BASEL
JI Biology-Basel
PD MAR
PY 2021
VL 10
IS 3
AR 194
DI 10.3390/biology10030194
PG 78
WC Biology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Life Sciences & Biomedicine - Other Topics
GA RD2JP
UT WOS:000633311500001
PM 33806509
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Marunaka, Y
AF Marunaka, Yoshinori
TI The Proposal of Molecular Mechanisms of Weak Organic Acids
   Intake-Induced Improvement of Insulin Resistance in Diabetes Mellitus
   via Elevation of Interstitial Fluid pH
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE weak organic acid; food; pH; interstitial fluid; insulin; binding
   affinity; alkalization
ID BROWN ADIPOSE-TISSUE; PROTEIN-KINASE-C; LOW URINE PH; SKELETAL-MUSCLE;
   GLUCOSE-UPTAKE; METABOLIC SYNDROME; BLOOD-PRESSURE; CARDIOVASCULAR RISK;
   OXIDATIVE STRESS; EXTRACELLULAR PH
AB Blood contains powerful pH-buffering molecules such as hemoglobin (Hb) and albumin, while interstitial fluids have little pH-buffering molecules. Thus, even under metabolic disorder conditions except severe cases, arterial blood pH is kept constant within the normal range (7.35 similar to 7.45), but the interstitial fluid pH under metabolic disorder conditions becomes lower than the normal level. Insulin resistance is one of the most important key factors in pathogenesis of diabetes mellitus, nevertheless the molecular mechanism of insulin resistance occurrence is still unclear. Our studies indicate that lowered interstitial fluid pH occurs in diabetes mellitus, causing insulin resistance via reduction of the binding affinity of insulin to its receptor. Therefore, the key point for improvement of insulin resistance occurring in diabetes mellitus is development of methods or techniques elevating the lowered interstitial fluid pH. Intake of weak organic acids is found to improve the insulin resistance by elevating the lowered interstitial fluid pH in diabetes mellitus. One of the molecular mechanisms of the pH elevation is that: (1) the carboxyl group (R-COO-) but not H+ composing weak organic acids in foods is absorbed into the body, and (2) the absorbed the carboxyl group (R-COO-) behaves as a pH buffer material, elevating the interstitial fluid pH. On the other hand, high salt intake has been suggested to cause diabetes mellitus; however, the molecular mechanism is unclear. A possible mechanism of high salt intake-caused diabetes mellitus is proposed from a viewpoint of regulation of the interstitial fluid pH: high salt intake lowers the interstitial fluid pH via high production of H+ associated with ATP synthesis required for the Na+,K+-ATPase to extrude the high leveled intracellular Na+ caused by high salt intake. This review article introduces the molecular mechanism causing the lowered interstitial fluid pH and insulin resistance in diabetes mellitus, the improvement of insulin resistance via intake of weak organic acid-containing foods, and a proposal mechanism of high salt intake-caused diabetes mellitus.
C1 [Marunaka, Yoshinori] Kyoto Ind Hlth Assoc, Res Inst Clin Physiol, Kyoto 6048472, Japan.
   [Marunaka, Yoshinori] Ritsumeikan Univ, Res Ctr Drug Discovery & Pharmaceut Dev Sci, Res Org Sci & Technol, Kusatsu 5258577, Japan.
   [Marunaka, Yoshinori] Kyoto Prefectural Univ Med, Grad Sch Med Sci, Dept Mol Cell Physiol, Kyoto 6028566, Japan.
   [Marunaka, Yoshinori] St Agnes Univ, Japan Inst Food Educ & Hlth, Kyoto 6028013, Japan.
C3 Ritsumeikan University; Kyoto Prefectural University of Medicine
RP Marunaka, Y (corresponding author), Kyoto Ind Hlth Assoc, Res Inst Clin Physiol, Kyoto 6048472, Japan.; Marunaka, Y (corresponding author), Ritsumeikan Univ, Res Ctr Drug Discovery & Pharmaceut Dev Sci, Res Org Sci & Technol, Kusatsu 5258577, Japan.; Marunaka, Y (corresponding author), Kyoto Prefectural Univ Med, Grad Sch Med Sci, Dept Mol Cell Physiol, Kyoto 6028566, Japan.; Marunaka, Y (corresponding author), St Agnes Univ, Japan Inst Food Educ & Hlth, Kyoto 6028013, Japan.
EM marunaka@koto.kpu-m.ac.jp
OI Marunaka, Yoshinori/0000-0003-3846-0937
FU Japan Society of the Promotion of Science (JSPS KAKENHI Grant)
   [JP15K15034, JP18H03182]; Salt Science Research Foundation [1235];
   Adaptable and Seamless Technology Transfer Program through target-driven
   R&D, Japan Science and Technology Agency (JST); KIT-KPUM-KPU-KPhU
   Collaborative Research Grant; Fuji Foundation for Protein Research, and
   the Cell Research Conference; Kyoto-Funding for Innovation in
   Health-related RD Fields
FX This research was funded by grants-in-aid from the Japan Society of the
   Promotion of Science (JSPS KAKENHI Grant Number JP15K15034 and
   JP18H03182), the Salt Science Research Foundation (1235), Adaptable and
   Seamless Technology Transfer Program through target-driven R&D, Japan
   Science and Technology Agency (JST; 2012), a KIT-KPUM-KPU-KPhU
   Collaborative Research Grant (2013 and 2015), the Kyoto-Funding for
   Innovation in Health-related R&D Fields, the Fuji Foundation for Protein
   Research, and the Cell Research Conference.
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NR 174
TC 46
Z9 47
U1 0
U2 14
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD OCT
PY 2018
VL 19
IS 10
AR 3244
DI 10.3390/ijms19103244
PG 24
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA GY9HB
UT WOS:000448951000399
PM 30347717
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Sen, S
   Rifas-Shiman, SL
   Shivappa, N
   Wirth, MD
   Hébert, JR
   Gold, DR
   Gillman, MW
   Oken, E
AF Sen, Sarbattama
   Rifas-Shiman, Sheryl L.
   Shivappa, Nitin
   Wirth, Michael D.
   Hebert, James R.
   Gold, Diane R.
   Gillman, Matthew W.
   Oken, Emily
TI Dietary Inflammatory Potential during Pregnancy Is Associated with Lower
   Fetal Growth and Breastfeeding Failure: Results from Project Viva
SO JOURNAL OF NUTRITION
LA English
DT Article
DE obesity; inflammation; pregnancy; diet; breastfeeding; fetal growth
ID C-REACTIVE PROTEIN; OXIDATIVE STRESS; METABOLIC SYNDROME;
   HEALTHY-ADULTS; MARKERS; INDEX; RISK; SUPPLEMENTATION; HYPERTENSION;
   OBESITY
AB Background: Inflammation during pregnancy has been linked to adverse maternal and infant outcomes. There is limited information available on the contribution of maternal diet to systemic inflammation and pregnancy health.
   Objective: The objective of this study was to examine associations of maternal prenatal dietary inflammatory index (DII), a composite measure of the inflammatory potential of diet, with markers of maternal systemic inflammation and pregnancy outcomes.
   Methods: We studied 1808 mother-child pairs from Project Viva, a pre-birth cohort study in Massachusetts. We calculated the DII from first-and second-trimester food-frequency questionnaires by standardizing the dietary intakes of participants to global means, which were multiplied by the inflammatory effect score and summed. We examined associations of DII with maternal plasma C-reactive protein and white blood cell count in the second trimester and the following perinatal outcomes: gestational diabetes, preeclampsia, length of gestation, fetal growth, mode of delivery, and duration of breastfeeding. We used multivariable linear and logistic regression models to analyze the strength of these associations.
   Results: Maternal age was (mean 6 SD) 32.2 +/- 5.0 y, prepregnancy body mass index (BMI; in kg/m(2)) was 24.9 +/- 5.2, and DII was -2.56 +/- 1.42 units with a range of -5.4 to 3.7. DII was positively correlated with prepregnancy BMI (Pearson's r = 0.13, P < 0.0001). Higher DII scores, reflecting more proinflammatory dietary potential, were associated with higher second trimester plasma CRP (beta: 0.08 mg/L per 1-unit increase in maternal DII; 95% CI: 0.02, 0.14) and lower birth weight for gestational age z score in infants born to obesemothers (b: 20.10 z score per 1-unit increase in maternal DII; 95% CI: 20.18, -0.02). Higher DII scores were associated with lower odds of breastfeeding for at least 1mo (OR = 0.85; 95% CI: 0.74, 0.98).
   Conclusion: A proinflammatory diet during pregnancy is associated with maternal systemic inflammation and may be associated with impaired fetal growth and breastfeeding failure.
C1 [Sen, Sarbattama] Brigham & Womens Hosp, Pediat Newborn Med, 75 Francis St, Boston, MA 02115 USA.
   [Gold, Diane R.] Brigham & Womens Hosp, Channing Lab, 75 Francis St, Boston, MA 02115 USA.
   [Rifas-Shiman, Sheryl L.; Gillman, Matthew W.; Oken, Emily] Harvard Univ, Sch Med, Dept Populat Med, Obes Prevent Program, Boston, MA 02115 USA.
   [Rifas-Shiman, Sheryl L.; Gillman, Matthew W.; Oken, Emily] Harvard Pilgrim Hlth Care Inst, Boston, MA USA.
   [Shivappa, Nitin; Wirth, Michael D.; Hebert, James R.] Univ S Carolina, South Carolina Statewide Canc Prevent & Control P, Columbia, SC 29208 USA.
   [Shivappa, Nitin; Wirth, Michael D.; Hebert, James R.] Univ S Carolina, Dept Epidemiol & Biostat, Columbia, SC 29208 USA.
   [Shivappa, Nitin; Wirth, Michael D.; Hebert, James R.] Connecting Hlth Innovat LLC, Columbia, SC USA.
C3 Harvard University; Harvard University Medical Affiliates; Brigham &
   Women's Hospital; Harvard University; Harvard University Medical
   Affiliates; Brigham & Women's Hospital; Harvard University; Harvard
   Medical School; Harvard Pilgrim Health Care; University of South
   Carolina System; University of South Carolina Columbia; University of
   South Carolina System; University of South Carolina Columbia; Connecting
   Health Innovations LLC
RP Sen, S (corresponding author), Brigham & Womens Hosp, Pediat Newborn Med, 75 Francis St, Boston, MA 02115 USA.
EM ssen2@partners.org
RI Shivappa, Nitin/X-2215-2018; Hebert, James/IUO-5628-2023; Wirth,
   Michael/C-6330-2013; Gold, Diane/HHM-6239-2022
FU National Institute of Child Health and Human Development [K23HD074648,
   R37HD034568, K24HD069408, R01AI102960]; National Institute of Diabetes
   and Digestive and Kidney Diseases [R44DK103377]
FX Supported by the National Institute of Child Health and Human
   Development (K23HD074648 to S Sen, R37HD034568 to MWG, K24HD069408 to
   EO, and R01AI102960 to DRG and EO) and National Institute of Diabetes
   and Digestive and Kidney Diseases (R44DK103377 to NS, MDW, and JRH).
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NR 42
TC 90
Z9 100
U1 0
U2 30
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0022-3166
EI 1541-6100
J9 J NUTR
JI J. Nutr.
PD APR
PY 2016
VL 146
IS 4
BP 728
EP 736
DI 10.3945/jn.115.225581
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA DI3RA
UT WOS:000373415000010
PM 26936137
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Ma, WW
   Chen, HG
   Deng, J
   Yuan, QP
   Li, HA
AF Ma, Weiwei
   Chen, Honggu
   Deng, Jing
   Yuan, Qipeng
   Li, Huanan
TI The role of triglycerides in predicting new-onset arthritis in the
   general population over 45 years old: evidence from the China health and
   retirement longitudinal study
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Article
DE arthritis; triglycerides; lipids; China health and retirement
   longitudinal study; longitudinal evidence
ID METABOLIC SYNDROME; OXIDATIVE STRESS; OSTEOARTHRITIS; RISK
AB Background: Arthritis is a common degenerative joint disease with a high prevalence especially in the elderly population. Due to its strong association with chronic pain and dysfunction, arthritis has become an important challenge in public health. Recent studies have shown that triglyceride (TG) levels, as key metabolic markers, may play an important role in the pathogenesis of arthritis, and its associated inflammatory response may accelerate joint degeneration and inflammatory process. Objective: Based on the above findings, the aim of this study was to investigate the association between baseline TG levels and the incidence of arthritis in adults aged 45 years and older, utilizing data from the China Health and Retirement Longitudinal Study(CHARLS). Methods: This study utilized the CHARLS from 2011 to 2018, which included 7,551 participants aged 45 years and older. The association between TG levels and new-onset arthritis was assessed by logistic regression modeling, adjusting for demographic and health-related variables. The potential role of HDL-C, LDL-C, and BMI in the TG-arthritis association was further assessed by mediation analysis, which decomposed the association into direct and indirect effects. Results: During the study period, 3,363 participants (44.5%) developed arthritis. Higher TG levels were significantly associated with arthritis risk, with an 8% increase in arthritis risk for each interquartile range (IQR) increase in TG (OR=1.08; 95% CI, 1.039-1.137.) Interquartile analyses of TG levels showed a significant dose-response trend (P trend <0.05), suggesting that the risk of arthritis tended to rise progressively with higher TG levels. Mediation analysis further revealed that HDL-C mediated approximately 43.5% of the TG-arthritis association, suggesting an important role of HDL-C in the metabolic pathway of arthritis development. Conclusion: Elevated TG levels were significantly associated with an increased risk of arthritis, and this association was partially mediated by HDL-C. The findings suggest that interventions targeting reduced TG levels and enhanced HDL function may have potential value in arthritis prevention. Future studies should focus on lipid metabolism intervention strategies to reduce arthritis risk and delay disease progression, providing a new scientific basis for arthritis management.
C1 [Ma, Weiwei; Yuan, Qipeng; Li, Huanan] Jiangxi Univ Chinese Med, Clin Med Coll, Nanchang, Peoples R China.
   [Chen, Honggu] Taizhou Hosp Zhejiang Prov, Orthopaed Dept, Taizhou, Peoples R China.
   [Deng, Jing] Guangxi Univ Chinese Med, Grad Sch, Nanning, Peoples R China.
   [Li, Huanan] Jiangxi Univ Chinese Med, Orthopaed Dept, Nanchang, Peoples R China.
C3 Jiangxi University of Traditional Chinese Medicine; Guangxi University
   of Chinese Medicine; Jiangxi University of Traditional Chinese Medicine
RP Li, HA (corresponding author), Jiangxi Univ Chinese Med, Clin Med Coll, Nanchang, Peoples R China.; Li, HA (corresponding author), Jiangxi Univ Chinese Med, Orthopaed Dept, Nanchang, Peoples R China.
EM lihuanan1974@126.com
RI li, huanan/IWM-7615-2023
FU National Natural Science Foundation of China [82060871]; Jiangxi
   Province 2024 Science and Technology Special Funds [20243BCE51009]
FX The author(s) declare that financial support was received for the
   research and/or publication of this article. This work was supported by
   grants from the National Natural Science Foundation of China (82060871)
   and Jiangxi Province 2024 Science and Technology Special Funds
   (20243BCE51009).The funders had no role in the study design or in the
   collection, analysis, and interpretation of the data, writing of the
   report, or decision to submit the article for publication.
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NR 40
TC 0
Z9 0
U1 0
U2 0
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD MAY 8
PY 2025
VL 16
AR 1530874
DI 10.3389/fendo.2025.1530874
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 2WD5K
UT WOS:001492743000001
PM 40405982
DA 2025-06-11
ER

PT J
AU Igboanugo, S
   O'Connor, C
   Zitoun, OA
   Ramezan, R
   Mielke, JG
AF Igboanugo, Somkene
   O'Connor, Claire
   Zitoun, Osama A.
   Ramezan, Reza
   Mielke, John G.
TI A systematic review of hair cortisol in healthy adults measured using
   immunoassays: Methodological considerations and proposed reference
   values for research
SO PSYCHOPHYSIOLOGY
LA English
DT Review
DE adult human; glucocorticoids; hair cortisol concentration; immunoassay;
   reference value
ID METABOLIC SYNDROME; CHRONIC STRESS; BIOMARKER; MARKER; INDIVIDUALS;
   SALIVARY; HUMANS; STATE
AB Hair cortisol concentration (HCC) has shown remarkable promise as a stable, non-invasive measure of systemic cortisol; however, despite methodological advances, the value that would typically be seen in healthy adults has not been established. Therefore, we sought to review the relevant literature to determine a reference value for HCC in healthy (i.e., non-clinical) adults. To this end, we conducted a systematic review of the PubMed, Scopus, and CINAHL databases for studies that measured healthy adult HCC using immunoassay methods, given that these are the most widely accessible analytical tools. To be eligible, studies were required to have been published in English, to have provided relevant descriptive statistics (i.e., means and standard deviations), and to have used a healthy adult human sample. We found 17 studies that met our inclusion criteria; the reports involved 1348 participants with a mean age of about 38 years. Since we identified a large amount of between-study heterogeneity, we completed a random-effect meta-regression analysis and found that test kit vendor was the only significant variable of the model. As a result, when using methodologies from traditional finite mixture distributions to determine reference values for mean and elevated HCC in individual healthy adults, we calculated these estimates for each of the major test kit vendors. Future work will need to determine whether our estimated reference values need to be modified, and these efforts will be greatly assisted by studies that account for potential moderating factors, such as age, sex, and ethnicity.
   Due to ease and cost, immunoassays are widely used for hair cortisol analysis. However, guidelines for typical hair cortisol concentration (HCC) in healthy adults are lacking. Therefore, we completed a systematic review of relevant studies and used methodologies from traditional finite mixture distributions to determine reference values for mean and elevated HCC in individual healthy adults. Given that our random-effect meta-regression analysis found test kit vendor to be the only significant variable of the model, we prepared estimates for each of the major test kit vendors.
C1 [Igboanugo, Somkene; O'Connor, Claire; Zitoun, Osama A.; Mielke, John G.] Univ Waterloo, Sch Publ Hlth Sci, Waterloo, ON, Canada.
   [Ramezan, Reza] Univ Waterloo, Dept Stat & Actuarial Sci, Waterloo, ON, Canada.
   [Mielke, John G.] Univ Waterloo, Sch Publ Hlth Sci, 200 Univ Ave West, Waterloo, ON N2L 3G1, Canada.
C3 University of Waterloo; University of Waterloo; University of Waterloo
RP Mielke, JG (corresponding author), Univ Waterloo, Sch Publ Hlth Sci, 200 Univ Ave West, Waterloo, ON N2L 3G1, Canada.
EM jgmielke@uwaterloo.ca
RI Zitoun, Osama/ABG-2417-2020; Igboanugo, Somkene/GYR-0236-2022
OI Mielke, John/0000-0002-2151-9691
FU This work was generously supported by an Occupational Health and Safety
   (OHS) Futures Grant provided to JGM by the Government of Alberta, Canada
   (grant number 095 244 771).; Occupational Health and Safety (OHS)
   Futures Grant [095 244 771]; Government of Alberta, Canada
FX This work was generously supported by an Occupational Health and Safety
   (OHS) Futures Grant provided to JGM by the Government of Alberta, Canada
   (grant number 095 244 771).
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NR 66
TC 5
Z9 5
U1 4
U2 8
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0048-5772
EI 1469-8986
J9 PSYCHOPHYSIOLOGY
JI Psychophysiology
PD JAN
PY 2024
VL 61
IS 1
DI 10.1111/psyp.14474
EA NOV 2023
PG 15
WC Psychology, Biological; Neurosciences; Physiology; Psychology;
   Psychology, Experimental
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Neurosciences & Neurology; Physiology
GA CB1Q0
UT WOS:001099695900001
PM 37950380
OA hybrid
DA 2025-06-11
ER

PT J
AU LaPenna, KB
   Werthmann, DW
   Rabito, FA
   Baker, JW
   Cook, MW
AF LaPenna, Kyle B.
   Werthmann, Derek W.
   Rabito, Felicia A.
   Baker, John W.
   Cook, Michael W.
TI Elevation of Serum Copper in the New Orleans Bariatric Clinic
   Population: the Norm or Geographically Localized Findings?
SO OBESITY SURGERY
LA English
DT Article
DE Obesity; Bariatric; Metabolic syndrome; Copper; Zinc; BMI; Age; Race
ID OXIDATIVE STRESS; OBESITY; INFLAMMATION; SURGERY; CANCER
AB Introduction Circulating micronutrient levels of both serum copper and zinc have been studied to varying degrees in both the general public and patients having undergone bariatric surgery. According to the 2019 ASMBS clinical guidelines, copper supplementation is recommended for patients undergoing metabolic surgery, especially after Roux-en-Y gastric bypass and duodenal switch. Copper excess has not been previously reported to any significant degree in any population.
   Objective In this study, we investigate an elevated serum copper level in the pre-surgical intervention population of the Bariatric Center of the University Medical Center-New Orleans, a primary safety net hospital for the state of Louisiana.
   Methods Five hundred five consecutive patients from the bariatric surgery undergoing a workup for surgical intervention were assessed. Patients were included regardless of whether they proceeded to surgery. The study was conducted as a retrospective review of deidentified data that was collected as part of our routine workup for bariatric surgery.
   Results The study population of the clinic consisted of a mean BMI of approximately 50 kg/m(2), with 91% of the population reporting female and 69% recording an African American race. It was discovered in this population that 26% of the patients had an elevated copper level of > 155 mcg/dl. Additional analysis was performed attempting to elucidate an environmental role in the elevation by qualitative analysis of patient's location of residence using reported home address. Additional variables were studied as well including serum zinc concentration, age, BMI, and race to address any correlative variables with our findings.
   Conclusion This study identifies an elevated serum copper concentration in a pre-intervention underserved bariatric center population positively associated with BMI, female gender, and African American race. Additional studies will be necessary to see if these trends are also apparent in normal weight controls, or if weight loss influences copper levels. Pre-existing serum copper deficiencies may be more prevalent in the bariatric populations than previously believed. Increased serum copper in this population was positively associated with increased BMI, age, and female gender compared to that of the male group. Increased serum copper was also associated more closely with African American ethnicity compared to Caucasian patients.
C1 [LaPenna, Kyle B.; Cook, Michael W.] Louisiana State Univ, Dept Surg, New Orleans Sch Med, New Orleans, LA USA.
   [Werthmann, Derek W.; Rabito, Felicia A.] Tulane Univ, Sch Publ Hlth & Trop Med, Dept Epidemiol, New Orleans, LA USA.
   [Baker, John W.] Tulane Univ, Sch Med, Dept Surg, Louisiana Med, New Orleans, LA 70112 USA.
C3 Louisiana State University System; Tulane University; Tulane University
RP Cook, MW (corresponding author), Louisiana State Univ, Dept Surg, New Orleans Sch Med, New Orleans, LA USA.
EM Mcoo11@lsuhsc.edu
RI Baker, John/Y-8268-2019; Cook, Michael/JCO-8381-2023
OI Cook, Michael/0000-0001-6719-7379; LaPenna, Kyle/0000-0003-0470-0138
CR Andolfi C, 2018, J LAPAROENDOSC ADV S, V28, P919, DOI 10.1089/lap.2018.0380
   Apovian Caroline M, 2016, Am J Manag Care, V22, ps176
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   Gu KF, 2020, BIOL TRACE ELEM RES, V194, P336, DOI 10.1007/s12011-019-01803-6
   Hales Craig M, 2020, NCHS Data Brief, P1, DOI 10.21608/seaf.2020.162168
   Kolb R, 2016, CURR OPIN PHARMACOL, V29, P77, DOI 10.1016/j.coph.2016.07.005
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NR 22
TC 2
Z9 2
U1 0
U2 1
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0960-8923
EI 1708-0428
J9 OBES SURG
JI Obes. Surg.
PD NOV
PY 2021
VL 31
IS 11
BP 4911
EP 4917
DI 10.1007/s11695-021-05666-6
EA AUG 2021
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA WB5PH
UT WOS:000685716200001
PM 34405337
DA 2025-06-11
ER

PT J
AU Hu, JW
   Wang, Y
   Chu, C
   Yan, Y
   Wang, KK
   Zheng, WL
   Ma, Q
   Lv, YB
   Deng, Y
   Yan, B
   Mu, JJ
AF Hu, Jia-Wen
   Wang, Yang
   Chu, Chao
   Yan, Yu
   Wang, Keke
   Zheng, Wenling
   Ma, Qiong
   Lv, Yong-bo
   Deng, Yin
   Yan, Bo
   Mu, Jian-Jun
TI The Relationships of the Fractional Excretion of Uric Acid with
   Brachial-Ankle Pulse Wave Velocity and Ankle Brachial Index in Chinese
   Young Adults
SO KIDNEY & BLOOD PRESSURE RESEARCH
LA English
DT Article
DE UA; FEUA; BaPWV; ABI
ID ALL-CAUSE MORTALITY; CARDIOVASCULAR RISK; ESSENTIAL-HYPERTENSION;
   ARTERIAL STIFFNESS; METABOLIC SYNDROME; JAPANESE INDIVIDUALS;
   GENERAL-POPULATION; OXIDATIVE STRESS; HEALTHY-ADULTS; BLOOD-PRESSURE
AB Background/Aims: Elevated serum uric acid (UA) was intimately correlated with vascular stiffness and abnormal ankle brachial index (ABI) in various populations. These correlations lost significance after adjustment for estimated glomerular filtration rate (eGFR), indicating that the association of UA and brachial-ankle pulse wave velocity (baPWV) or ABI might be driven by kidney function. UA is predominantly eliminated through the kidneys, and metabolic disorders can influence the clearance of UA. In this study, we aimed to explore the putative correlation between FEUA and baPWV or ABI to determine to what extent the associations with UA were affected by renal function. Methods: This cross-sectional study enrolled 2351 participants, who underwent general health screening in Hanzhong people's hospital from March to June of 2017. BaPWV and ABI were measured using a volume-plethysmographic apparatus (BP-203RPEII; Nihon Colin, Tokyo, Japan). FEUA was divided into quartiles: Q1:FEUA <= 3.07; Q2:3.07<FEUA <= 5.32; Q3: 5.32<FEUA <= 9.19; and Q4: FEUA>9.19. Results: Lower FEUA predicted a higher prevalence of high baPWV and low ABI (p for trend <0.001). The respective ORs for high baPWV from the first to the third quartiles of FEUA were 1.777(1.323, 2.387); 1.561(1.158, 2.104); and 1.680 (1.250, 2.259). The prevalence of low ABI was greatly elevated with the decrement of FEUA [ORs for the first to third FEUA quartiles were 6.977(2.062, 23.610); 5.123(1.475, 17.790); and 2.685(0.709, 10.171), respectively]. The association of FEUA and ABI was independent of related confounding factors. However, the association between FEUA and baPWV was greatly influenced by corresponding confounders, especially gender. The efficacy of FEUA in the prediction of low ABI was stronger than that of serum UA. However, serum UA was more powerful in the prediction of high baPWV. Conclusion: Kidney function exerted a profound influence on the relationship between UA and baPWV or ABI, revealing complex interactions among cardiovascular risk factors. (C) 2018 The Author(s) Published by S. Karger AG, Basel
C1 [Hu, Jia-Wen; Wang, Yang; Chu, Chao; Yan, Yu; Wang, Keke; Zheng, Wenling; Ma, Qiong; Lv, Yong-bo; Deng, Yin; Yan, Bo; Mu, Jian-Jun] Xi An Jiao Tong Univ, Med Sch, Affiliated Hosp 1, Dept Cardiol, 277 Yanta West Rd, Xian 710061, Shaanxi, Peoples R China.
   [Hu, Jia-Wen; Wang, Yang; Chu, Chao; Yan, Yu; Wang, Keke; Zheng, Wenling; Ma, Qiong; Lv, Yong-bo; Mu, Jian-Jun] Key Lab Mol Cardiol Shaanxi Prov, Xian, Shaanxi, Peoples R China.
C3 Xi'an Jiaotong University
RP Mu, JJ (corresponding author), Xi An Jiao Tong Univ, Med Sch, Affiliated Hosp 1, Dept Cardiol, 277 Yanta West Rd, Xian 710061, Shaanxi, Peoples R China.
EM mujjun@163.com
RI Yan, Yu/KAM-4269-2024
OI Lyu, Yongbo/0000-0002-1759-8673; Yan, Yu/0000-0001-5942-5853
FU National Natural Science Foundation of China [81370357, 81570381,
   81600327, 81700368]; Clinical Research Award of the First Affiliated
   Hospital of Xi'an Jiaotong University of China [XJTU1AF-CRF-2015-006];
   Ministry of Science and Technology of the People's Republic of China
   [2017YFC1307604]; Key Research Project of Shaanxi Province
   [2017ZDXM-SF-107]
FX This work was supported by the National Natural Science Foundation of
   China No. 81370357, No. 81570381 (J.-J.M.), No. 81600327 (Y.W.) and No.
   81700368 (C.C.), the Clinical Research Award of the First Affiliated
   Hospital of Xi'an Jiaotong University of China No. XJTU1AF-CRF-2015-006,
   Grant 2017YFC1307604 from the Major Chronic Non-communicable Disease
   Prevention and Control Research Key Project of the Ministry of Science
   and Technology of the People's Republic of China, and Grant
   2017ZDXM-SF-107 from the Key Research Project of Shaanxi Province.
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NR 45
TC 6
Z9 6
U1 0
U2 5
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1420-4096
EI 1423-0143
J9 KIDNEY BLOOD PRESS R
JI Kidney Blood Pressure Res.
PY 2018
VL 43
IS 1
BP 234
EP 245
DI 10.1159/000487677
PG 12
WC Physiology; Urology & Nephrology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology; Urology & Nephrology; Cardiovascular System & Cardiology
GA GB1OH
UT WOS:000428819600023
PM 29587296
OA gold
DA 2025-06-11
ER

PT J
AU DiMarco, DM
   Norris, GH
   Millar, CL
   Blesso, CN
   Fernandez, ML
AF DiMarco, Diana M.
   Norris, Gregory H.
   Millar, Courtney L.
   Blesso, Christopher N.
   Fernandez, Maria Luz
TI Intake of up to 3 Eggs per Day Is Associated with Changes in HDL
   Function and Increased Plasma Antioxidants in Healthy, Young Adults
SO JOURNAL OF NUTRITION
LA English
DT Article
DE eggs; healthy population; HDL function; lecithin cholesterol
   acyltransferase; plasma carotenoids; paraoxonase-1
ID HIGH-DENSITY-LIPOPROTEIN; CORONARY-HEART-DISEASE;
   MAGNETIC-RESONANCE-SPECTROSCOPY; DIETARY-CHOLESTEROL; METABOLIC
   SYNDROME; OXIDATIVE STRESS; ENZYME-ACTIVITY; ATHEROSCLEROSIS;
   PARAOXONASE; INFLAMMATION
AB Background: HDL functionmay bemore important than HDL concentration in determining risk for cardiovascular disease. In addition, HDL is a carrier of carotenoids and antioxidant enzymes, which protect HDL and LDL particles against oxidation.
   Objective: The goal of this study was to determine the impact of consuming 0-3 eggs/d on LDL and HDL particle size, HDL function, and plasma antioxidants in a young, healthy population.
   Methods: Thirty-eight healthy men and women [age 18-30 y, body mass index (in kg/m(2)) 18.5-29.9] participated in this 14-wk crossover intervention. Subjects underwent a 2-wk washout (0 eggs/d) followed by sequentially increasing intake of 1, 2, and 3 eggs/d for 4 wk each. After each period, fasting blood was collected for analysis of lipoprotein subfractions, plasma apolipoprotein (apo) concentration, lutein and zeaxanthin concentration, and activities of lecithin-cholesterol acyltransferase, cholesteryl ester transfer protein, and paraoxonase-1.
   Results: Compared with intake of 0 eggs/d, consuming 1-3 eggs/d resulted in increased large-LDL (21-37%) and largeHDL (6-13%) particle concentrations, plasma apoAI (9-15%), and lecithin-cholesterol acyltransferase activity (5-15%) (P < 0.05 for all biomarkers). Intake of 2-3 eggs/d also promoted an 11% increase in apoAII (P < 0.05) and a 20-31% increase in plasma lutein and zeaxanthin (P < 0.05), whereas intake of 3 eggs/d resulted in a 9-16% increase in serum paraoxonase1 activity compared with intake of 1-2 eggs/d (P < 0.05). Egg intake did not affect cholesteryl ester transfer protein activity.
   Conclusions: Intake of 1 egg/d was sufficient to increase HDL function and large-LDL particle concentration; however, intake of 2-3 eggs/d supported greater improvements in HDL function as well as increased plasma carotenoids. Overall, intake of # 3 eggs/d favored a less atherogenic LDL particle profile, improved HDL function, and increased plasma antioxidants in young, healthy adults. This trial was registered at clinicaltrials. gov as NCT02531958.
C1 [DiMarco, Diana M.; Norris, Gregory H.; Millar, Courtney L.; Blesso, Christopher N.; Fernandez, Maria Luz] Univ Connecticut, Dept Nutrit Sci, Storrs, CT USA.
C3 University of Connecticut
RP Fernandez, ML (corresponding author), Univ Connecticut, Dept Nutrit Sci, Storrs, CT USA.
EM maria-luz.fernandez@uconn.edu
RI Blesso, Christopher/N-9495-2014
FU Esperance Family Foundation; Egg Nutrition Center
FX Supported by an award to MLF from the Esperance Family Foundation and a
   grant to DMD from the Egg Nutrition Center.
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NR 47
TC 49
Z9 60
U1 0
U2 27
PU AMER SOC NUTRITION-ASN
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0022-3166
EI 1541-6100
J9 J NUTR
JI J. Nutr.
PD MAR
PY 2017
VL 147
IS 3
BP 323
EP 329
DI 10.3945/jn.116.241877
PG 7
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA EQ4EY
UT WOS:000398028800006
PM 28077734
OA Bronze
DA 2025-06-11
ER

PT J
AU Dhanavathy, G
AF Dhanavathy, G.
TI Immunohistochemistry, histopathology, and biomarker studies of
   swertiamarin, a secoiridoid glycoside, prevents and protects
   streptozotocin-induced β-cell damage in Wistar rat pancreas
SO JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
LA English
DT Article
DE Swertiamarin; Neuropathy; Nephropathy; Morphometry; Streptozotocin
ID ENICOSTEMMA-LITTORALE BLUME; AQUEOUS EXTRACT; INSULIN-RESISTANCE;
   DIABETES-MELLITUS; OXIDATIVE STRESS; SERUM; EXPRESSION; GLYCOGEN;
   GLUCOSE; BARK
AB Background Diabetes mellitus is globally the major cause for metabolic syndrome in STZ-induced diabetic rats, leading to mortality. Treatment of diabetes by oral hypoglycemic agents causes adverse side effects and thus treatment with natural herbal drugs like swertiamarin is promising. Swertiamarin, an active compound isolated from Enicostemma littorale possesses antidiabetic activity and enhances beta cell regeneration which causes reversal of diabetes.
   Objectives The present study aims at the following: (1) to evaluate antidiabetic, anti-hyperlipidaemic, activity of swertiamarin in Streptozotocin-induced diabetic rats using biomarkers. (2) To assess histopathological alterations in Pancreas, Liver, Kidney, and Heart of swertiamarin-treated STZ-induced diabetic rats and confirm cytoprotective activity of swertiamarin by Immunohistochemistry and morphometric investigations.
   Methods Diabetes was induced intraperitoneally in male Wistar rats by Streptozotocin (STZ 50 mg/kg). After STZ-induction, hyperglycemic rats were treated with doses of swertiamarin orally (15, 25, 50 mg/kg) each for 28 days. Glibenclamide (2.5 mg/kg), a sulphonyl urea, was used as a standard drug. The glycemic control was measured by the biochemical parameter assays. Histopathology analysis of organs and immunohistochemistry of islets were carried out.
   Results Our study results showed that oral administration of swertiamarin at a dosage of 15, 25, 50 mg/kg bw for 28 days resulted in a significant (p < 0.01) decrease in fasting blood glucose, HbA1c, TC, TG, LDL, and increased the levels of hemoglobin, plasma insulin, TP, body weight, and HDL levels significantly (p < 0.01) when compared to STZ-induced diabetic rats, as confirmed by immunohistochemical studies. The effect of swertiamarin on Carbohydrate-metabolizing enzymes was investigated and found to have normal therapeutic activity. Histopathological studies of Pancreas of swertiamarin-treated diabetic rats showed regeneration of islets when compared to STZ-induced diabetic rats, as confirmed by immunohistochemical studies.
   Conclusion Our research results clearly substantiate that swertiamarin possesses antihyperglycemic, antihyperlipidemic, cytoprotective, and immune reactivity and also a broad spectrum potential of treating diabetes and other complications related to diabetes and hence can be developed into a potent oral antidiabetic drug.
C1 SRM Univ, Dept Biotechnol, Madras 603203, Tamil Nadu, India.
C3 SRM Institute of Science & Technology Chennai
RP Dhanavathy, G (corresponding author), SRM Univ, Dept Biotechnol, Madras 603203, Tamil Nadu, India.
EM dhanavathy.rajabala@gmail.com
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NR 71
TC 23
Z9 25
U1 1
U2 19
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0391-4097
EI 1720-8386
J9 J ENDOCRINOL INVEST
JI J. Endocrinol. Invest.
PD JUN
PY 2015
VL 38
IS 6
BP 669
EP 684
DI 10.1007/s40618-015-0243-5
PG 16
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA CI0CO
UT WOS:000354403600011
PM 25770453
DA 2025-06-11
ER

PT J
AU Eldin, EEMN
   Almarzouki, A
   Assiri, AM
   Elsheikh, OM
   Mohamed, BEA
   Babakr, AT
AF Eldin, Essam Eldin Mohamed Nour
   Almarzouki, Abdullah
   Assiri, Adel Mohamed
   Elsheikh, Osman Mohammed
   Mohamed, Badreldin Elsonni Abdalla
   Babakr, Abdullatif Taha
TI Oxidized low density lipoprotein and total antioxidant capacity in
   type-2 diabetic and impaired glucose tolerance Saudi men
SO DIABETOLOGY & METABOLIC SYNDROME
LA English
DT Article
DE Oxidized LDL (Ox-LDL); Total antioxidant capacity; Prediabetics;
   Malondialdehyde (MDA)
ID OXIDATIVE STRESS; LDL CONCENTRATIONS; METABOLIC SYNDROME; PLASMA;
   MELLITUS; CONSUMPTION; ASSOCIATION; PREVALENCE; DISEASE; PROFILE
AB Background: Oxidative modification of low density lipoproteins (LDL) convert these native particles into pathogenic, immunogenic and atherogenic particles. Factors enhance LDL oxidation are poorly understood, especially in conditions of hyperglycemia. The present study was conducted to investigate which metabolic conditions are associated with the promotion of LDL oxidation in different glycemic situations.
   Methods: Adult male participants (274) were selected from patients admitted to the outpatient department of Diabetes Center in Al-Noor Specialized Hospital in Makkah and other citizens and residents in the city. The studied group was classified into three sub-groups: Group-I: control group of non-diabetic normal subjects, Group-II: subjects with impaired glucose tolerance (IGT) and Group-III: cases of type-2 diabetes mellitus (DM). Measurement of fasting blood glucose, 2 hour post-prandial blood glucose, glycosylated hemoglobin (HbA1c), triglycerides, serum cholesterol, HDL-cholesterol, LDL-cholesterol, ox-LDL, Total Antoxidant capacity (TAC) and Malondialdehyde (MDA) were performed. The obtained results were statistically analyzed.
   Results: Oxidation of native LDL increase nearly two folds in Type-2 DM group compared to controls. There is also significant increase in Ox-LDL of IGT group compared to controls. The correlation between Ox-LDL concentration and HbA1c in the whole population of the study confirms the increased Ox-LDL in subjects with hyperglycemia. A negative correlation exists between the concentration of Ox-LDL and total antioxidant capacity (TAC) in each studied group and in the whole population of the study as well. A positive correlation also exists between Ox-LDL concentrations and LDL values, more clear in controls and Type-2 DM, while this correlation was not significant in IGT group. The ratio of LDL oxidation as expressed by ox-LDL/LDL was increased in IGT group compared to control. More significant increase was observed in type-2 DM group.
   Conclusion: We concluded that the concentration of Ox-LDL increased in subjects with type-2 DM and IGT compared to controls. Moreover, oxidation of native LDL was associated with low levels of TAC and positively correlated with LDL levels, total cholesterol, HbA1c, body mass index (BMI) and increased age.
C1 [Eldin, Essam Eldin Mohamed Nour; Assiri, Adel Mohamed] Umm Al Qura Univ, Fac Med, Dept Med Biochem, Abdia, Makkah, Saudi Arabia.
   [Almarzouki, Abdullah] Umm Al Qura Univ, Dept Internal Med, Fac Med, Mecca, Saudi Arabia.
   [Elsheikh, Osman Mohammed] Int Univ Africa, Dept Biochem, Fac Med, Khartoum, Sudan.
   [Mohamed, Badreldin Elsonni Abdalla] King Abdulaziz Univ, Sci Fac Girls, Dept Biochem, Jeddah 21413, Saudi Arabia.
   [Babakr, Abdullatif Taha] Umm Al Qura Univ, Fac Med, Dept Med Biochem, Mecca, Saudi Arabia.
C3 Umm Al-Qura University; Umm Al-Qura University; King Abdulaziz
   University; Umm Al-Qura University
RP Eldin, EEMN (corresponding author), Umm Al Qura Univ, Fac Med, Dept Med Biochem, Abdia, Makkah, Saudi Arabia.
EM emattia@uqu.edu.sa
RI Noureldin, Essam Eldin/JAC-7558-2023; Noureldin, Siddig/HPD-5414-2023;
   Babakr, Abdullatif/AGJ-6342-2022
OI Babakr, Abdullatif/0000-0003-0966-9707; Mohamed Noureldin,
   Essameldin/0000-0001-7263-7527
FU Institute of Scientific Research and Revival of Islamic Culture, Umm
   Al-Qura University, Makkah, KSA [43109012]
FX This research project was supported and funded by the Institute of
   Scientific Research and Revival of Islamic Culture (Grant No. 43109012),
   Umm Al-Qura University, Makkah, KSA.
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NR 43
TC 24
Z9 25
U1 0
U2 7
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1758-5996
J9 DIABETOL METAB SYNDR
JI Diabetol. Metab. Syndr.
PD AUG 30
PY 2014
VL 6
AR 94
DI 10.1186/1758-5996-6-94
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA AP4KG
UT WOS:000342045000001
PM 25221629
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Alsherif, DA
   Hussein, MA
   Abuelkasem, SS
AF Alsherif, Diana A.
   Hussein, Mohammed A.
   Abuelkasem, Suzan S.
TI Salvia officinalis Improves Glycemia and Suppresses
   Pro-inflammatory Features in Obese Rats with Metabolic Syndrome
SO CURRENT PHARMACEUTICAL BIOTECHNOLOGY
LA English
DT Article
DE SAGE; insulin; leptin; PCK1; GK; LepRb; SIRT1; adiponectin; GLUT4;
   mRNA33-5P
ID FATTY LIVER-DISEASE; INSULIN-RESISTANCE; CLINICAL-IMPLICATIONS; SIRTUIN
   SYSTEM; ADIPOSE-TISSUE; POTENTIAL ROLE; RESVERATROL; SERUM; DYSFUNCTION;
   PROTEIN-1
AB Objectives: Obesity is regarded as the main cause of metabolic diseases and a core factor for all-cause mortality in the general population, notably from cardiovascular disease. The majority of people with type 2 diabetes have obesity and insulin resistance. Some evidence indicates that an individual with obesity is approximately 10 times more likely to develop type 2 diabetes than someone with moderate body weight. One of the most significant therapeutic herbs, Salvia officinalis (Lamiaceae) (SAGE), possesses potent medicinal importance. The aim of this article was to evaluate the anti-diabetic and antiobesity activity of SAGEAE against HFD-induced obesity in rats. Methods: Thirty adult albino rats were randomly divided into five equal groups: control, High-fat Diet (HFD) administrated rats, HFD + Salvia officinalis Aqueous Extract (SAGEAE) (150 mg/kg.bw.), HFD + SAGEAE (300 mg/kg.bw.) and HFD + metformin (500 mg/kg.bw.). Body weight, plasma biochemical parameters, oxidative stress, inflammatory indicators, hepatic Phosphoenolpyruvate Carboxykinase 1 (PCK1), Glucokinase (GK), brain Leptin Receptor (LepRb), Glucose Transporter-4 (GLUT4), Sirtuin 1 (SIRT1) and mRNA33-5P gene signalling mRNA levels were all assessed after 8 weeks. A histological examination of the liver was also performed to check for lipid accumulation. Results: The administration of HFD resulted in increased body weight, glucose, insulin, leptin, Total Cholesterol (TC), Triglycerides (TG), Thiobarbaturic Acid Reactive Substances (TBARS), Monocyte Chemoattractant Protein-1 (MCP1), Interleukine-6 (IL-6) and tumor necrosis factor-alpha (TNF- alpha) as well as hepatic PCK1, brain LepRb and adipose tissue mRNA33-5P gene expression. However, our findings revealed a significant reduction in adiponectin, High-density Lipoproteincholesterol (HDL-C), reduced glutathione (GSH) and Superoxide Dismutase (SOD) levels as well as the expression of hepatic GK and adipose tissue SIRT1 and GLUT4 genes. Also, administration of SAGEAE significantly normalized body weight, glucose, insulin, leptin, adiponectin, TC, TG, HDL-C, TBARs, SOD, IL-6, MCP-1 and TNF-alpha in plasma and liver tissue of HFD-treated rats. On the other hand, PCK1, GK, LepRb, SIRT1, GLUT4 and mRNA33-5P gene expression was enhanced in obese rats when administrated with SAGEAE. Histological and US studies support the biochemical, PCR and electrophoretic results.
C1 [Alsherif, Diana A.] October 6th Univ, Fac Appl Hlth Sci Technol, Dept Radiol & Med Imaging, October 6th City, Egypt.
   [Hussein, Mohammed A.] October 6th Univ, Fac Appl Hlth Sci Technol, Dept Biotechnol, October 6th City, Egypt.
   [Abuelkasem, Suzan S.] October 6th Univ, Fac Appl Hlth Sci Technol, Dept Biochem, October 6th City, Egypt.
C3 Egyptian Knowledge Bank (EKB); October 6 University (O6U); Egyptian
   Knowledge Bank (EKB); October 6 University (O6U); Egyptian Knowledge
   Bank (EKB); October 6 University (O6U)
RP Hussein, MA (corresponding author), October 6th Univ, Fac Appl Hlth Sci Technol, Dept Biotechnol, October 6th City, Egypt.
EM Prof.husseinma@o6u.edu.eg
RI Abdalla Hussein, Prof. Mohammed/LSK-9218-2024
OI Hussein, Prof. Mohammed Abdalla/0000-0002-1811-2794
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NR 73
TC 6
Z9 6
U1 1
U2 6
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1389-2010
EI 1873-4316
J9 CURR PHARM BIOTECHNO
JI Curr. Pharm. Biotechnol.
PY 2024
VL 25
IS 5
BP 623
EP 636
DI 10.2174/1389201024666230811104740
PG 14
WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
GA OB2E3
UT WOS:001204727000005
PM 37581324
DA 2025-06-11
ER

PT J
AU Wang, P
   Zhang, Q
   Hou, HJ
   Liu, ZY
   Wang, L
   Rasekhmagham, R
   Kord-Varkaneh, H
   Santos, HO
   Yao, GT
AF Wang, Peng
   Zhang, Qiang
   Hou, Huijuan
   Liu, Zhiyong
   Wang, Li
   Rasekhmagham, Reyhaneh
   Kord-Varkaneh, Hamed
   Santos, Heitor O.
   Yao, Guangtao
TI The effects of pomegranate supplementation on biomarkers of inflammation
   and endothelial dysfunction: A meta-analysis and systematic review
SO COMPLEMENTARY THERAPIES IN MEDICINE
LA English
DT Review
DE Meta-analysis; Inflammation; Endothelial; Pomegranate
ID C-REACTIVE PROTEIN; CARDIOVASCULAR RISK-FACTORS; INTIMA-MEDIA THICKNESS;
   JUICE CONSUMPTION; TNF-ALPHA; METABOLIC SYNDROME; OXIDATIVE STRESS;
   BLOOD-PRESSURE; IN-VITRO; EXTRACT
AB Objects: Cardiovascular disease (CVD) is one of the leading causes of death worldwide. CVD is associated with increased levels of reactive oxygen species which are pro-inflammatory and can damage the endothelium. The pomegranate fruit is a rich source of phytochemicals with a high antioxidant and anti-inflammatory activity, possessing thus health benefits. This systematic review and meta-analysis aims to evaluate the effect of pomegranate juice on the biomarkers of inflammation and vascular dysfunction.
   Methods: Studies were identified using the PubMed/Medline and SCOPUS databases. Screening of relevant articles and references was carried out from inception until May 2019. This systematic review and meta-analysis was performed using the Preferred Items for Reporting of Systematic Reviews and Meta-Analyses (PRISMA) guidelines.
   Results: Overall, 16 randomized controlled trials (RCTs) involving 572 subjects were included in this study. Combining effect sizes from 16 studies, we recorded that pomegranate supplementation significantly reduced hsCRP, IL-6 and TNF-alpha (Weighted Mean Differences (WMD): -6.57 mg/L, 95 % CI: -10.04 to -3.10, P = 0.000; WMD: -1.68 pg/mL, 95 % CI: -3.52, 0.157, P = 0.000; WMD: -2.37 pg/mL, 95 % CI: -3.67, -1.07, P = 0.00, respectively) levels, when compared to placebo. No significant reduction was found in CRP (WMD: 2.19 mg/dL, 95 % CI: -3.28, 7.67, P = 0.61), E-selectin (WMD: 8.42 ng/mL, 95 % CI: -22.9, 39.8, P= 0.599), ICAM (WMD= -17.38 ng/mL, 95 % CI: -53.43, 18.66, P = 0.107), VCAM (WMD: -69.32 ng/mL, 95 % CI: -229.26, 90.61, P = 0.396) or MDA (WMD: 0.031 mu mol/L, 95 % CI: -1.56, 0.218, P = 0.746) comparing pomegranate supplementation to placebo.
   Conclusion: We found a significant effect of pomegranate supplementation on hs-CRP, IL-6 and TNF-alpha in adults. However, the effects of pomegranate supplementation on CRP, E-selectin, ICAM, VCAM or MDA were not significant in this meta-analysis.
C1 [Wang, Peng; Zhang, Qiang; Hou, Huijuan; Liu, Zhiyong; Yao, Guangtao] Dezhou Peoples Hosp, Dept Cardiovasc, 1166 Dongfanghong West Rd, Dezhou City 253000, Shandong, Peoples R China.
   [Wang, Li] Yucheng Peoples Hosp, Dept Gastroenterol, 753 Kaifa Rd, Yucheng City 251200, Shandong, Peoples R China.
   [Rasekhmagham, Reyhaneh] Islamic Azad Univ, Fac Med Sci, Dept Nutr, Sci & Res Branch, Tehran, Iran.
   [Kord-Varkaneh, Hamed] Shahid Beheshti Univ Med Sci, Fac Nutr & Food Technol, Dept Clin Nutr & Dietet, Student Res Comm, Tehran, Iran.
   [Santos, Heitor O.] Fed Univ Uberlandia UFU, Sch Med, Uberlandia, MG, Brazil.
C3 Islamic Azad University; Shahid Beheshti University Medical Sciences;
   Universidade Federal de Uberlandia
RP Yao, GT (corresponding author), Dezhou Peoples Hosp, Dept Cardiovasc, 1166 Dongfanghong West Rd, Dezhou City 253000, Shandong, Peoples R China.
EM yaoguangtao1976@sina.com
RI hou, huijuan/KIG-5279-2024
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NR 55
TC 48
Z9 49
U1 0
U2 7
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0965-2299
EI 1873-6963
J9 COMPLEMENT THER MED
JI Complement. Ther. Med.
PD MAR
PY 2020
VL 49
AR 102358
DI 10.1016/j.ctim.2020.102358
PG 8
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA LG1NY
UT WOS:000527877700057
PM 32147056
DA 2025-06-11
ER

PT J
AU Beraldo, RA
   Meliscki, GC
   Silva, BR
   Navarro, AM
   Bollela, VR
   Schmidt, A
   Foss-Freitas, MC
AF Beraldo, Rebeca A.
   Meliscki, Gabriela C.
   Silva, Bruna R.
   Navarro, Anderson M.
   Bollela, Valdes R.
   Schmidt, Andre
   Foss-Freitas, Maria C.
TI Anthropometric measures of central adiposity are highly concordant with
   predictors of cardiovascular disease risk in HIV patients
SO AMERICAN JOURNAL OF CLINICAL NUTRITION
LA English
DT Article
DE cardiovascular disease risk; HIV; lipodystrophy; anthropometry;
   adiposity indexes; cutoffs
ID BODY-MASS INDEX; TO-HEIGHT RATIO; WAIST CIRCUMFERENCE; METABOLIC
   SYNDROME; ANTIRETROVIRAL THERAPY; MYOCARDIAL-INFARCTION; NECK
   CIRCUMFERENCE; SCREENING TOOL; OBESITY; FAT
AB Background: Body fat redistribution and metabolic abnormalities found in HIV patients receiving highly active antiretroviral therapy (HAART) contribute to an atherogenic profile, increasing cardiovascular disease risk.
   Objective: We aimed to evaluate adiposity measures/indexes and propose cutoffs associated with predictors of cardiovascular disease risk in HIV patients on HAART.
   Design: To evaluate cardiovascular disease risk in this crosssectional study, we conducted electrocardiogram exams and stress electrocardiography, measured the ankle brachial index and blood pressure arterial hypertension, conducted lipid biochemical tests, and measured blood glucose. We measured circumferences [waist (WC), hip, thigh, calf, neck, trunk] and skinfold thicknesses (biceps, triceps, subscapular, suprailiac), conducted bioelectrical impedance analysis (BIA), and calculated indexes [body mass index, waist-to-hip ratio, waist-to-thigh ratio, waist-to-calf ratio, waist-to-height ratio (WHtR), trunk-to-arm ratio, body mass index corrected for body fat mass, Body Adiposity Index, comcity index, body shape index, fat mass (percentage), and phase angle]. For evaluating the performance of all adiposity measures/indexes, we used receiver operating characteristic (ROC) curves.
   Results: Measures of central adiposity WC and WHtR showed the best performances-WC area under the curve (AUC) for men: 0.83 (95% Cl: 0.78, 0.89; P < 0.05); WC AUC for women: 0.86 (95% CI: 0.81, 0.91; P < 0.05); WHtR AUC for men: 0.83 (95% CI: 0.78, 0.88; P < 0.05); and WHtR AUC for women: 0.85 (95% CI: 0.80, 0.91; P < 0.05). All adiposity measures/indexes presented different cutoffs from those proposed for the HIV seronegative population. The cutoffs for WC were 87.75 cm (sensitivity: 82.2%; specificity: 75.5%) for men and 90.5 cm (sensitivity: 84.0%; specificity: 73.0%) for women.
   Conclusions: The measures/indexes of central adiposity presented excellent associations with predictors of cardiovascular disease risk, and the use of the cutoffs proposed in the present study aims to contribute to the early identification of increasing risk of cardiovascular diseases, enabling interventions. This trial was registered at the Brazilian clinical trials registry Registro brasileiro de ensaios clmicos (Rebec) as RBR-9rcxbq. Am J Clin Nutr 2018;107:883-893.
C1 [Beraldo, Rebeca A.; Navarro, Anderson M.; Bollela, Valdes R.; Schmidt, Andre; Foss-Freitas, Maria C.] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Internal Med, Ribeirao Preto, SP, Brazil.
   [Meliscki, Gabriela C.; Silva, Bruna R.] Univ Sao Paulo, Ribeirao Preto Med Sch, Nutr & Metab Grad Course, Ribeirao Preto, SP, Brazil.
C3 Universidade de Sao Paulo; Universidade de Sao Paulo
RP Beraldo, RA (corresponding author), Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Internal Med, Ribeirao Preto, SP, Brazil.
EM rebecaberaldo@yahoo.com.br
RI da Silva, Bruna/JNR-9840-2023; Beraldo, Rebeca/J-7380-2016; Schmidt,
   André/G-1569-2011; Foss-Freitas, Maria/AAV-5971-2021; Bollela,
   Valdes/JCD-7777-2023; Navarro, Anderson Marliere/D-8601-2016;
   Foss-Freitas, Maria Cristina/F-1197-2013
OI Ramos da Silva, Bruna/0000-0002-8674-5753; Navarro, Anderson
   Marliere/0000-0001-9127-3001; Foss-Freitas, Maria
   Cristina/0000-0002-1350-1125
FU Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
   [2013/23287-3, 2016/14698-8]; Fundacao de Amparo a Pesquisa do Estado de
   Sao Paulo (FAPESP) [13/23287-3, 16/14698-8] Funding Source: FAPESP
FX Supported by Fundacao de Amparo a Pesquisa do Estado de Sao Paulo
   (FAPESP), to RAB (process numbers: 2013/23287-3 and 2016/14698-8).
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NR 56
TC 17
Z9 17
U1 0
U2 1
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0002-9165
EI 1938-3207
J9 AM J CLIN NUTR
JI Am. J. Clin. Nutr.
PD JUN
PY 2018
VL 107
IS 6
BP 883
EP 893
DI 10.1093/ajcn/nqy049
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA GJ5YJ
UT WOS:000435459400007
PM 29868914
OA Bronze
DA 2025-06-11
ER

PT J
AU Nestel, PJ
   Mellett, N
   Pally, S
   Wong, G
   Barlow, CK
   Croft, K
   Mori, TA
   Meikle, PJ
AF Nestel, Paul J.
   Mellett, Natalie
   Pally, Suzana
   Wong, Gerard
   Barlow, Chris K.
   Croft, Kevin
   Mori, Trevor A.
   Meikle, Peter J.
TI Effects of low-fat or full-fat fermented and non-fermented dairy foods
   on selected cardiovascular biomarkers in overweight adults
SO BRITISH JOURNAL OF NUTRITION
LA English
DT Article
DE Fermented dairy foods; Nutrition trials; Inflammatory biomarkers;
   Lipidomics
ID CORONARY-HEART-DISEASE; PLASMA SPHINGOMYELIN; METABOLIC SYNDROME; RISK;
   OBESE; ATHEROSCLEROSIS; INFLAMMATION; CONSUMPTION; MARKERS; EVENTS
AB The association between consumption of full-fat dairy foods and CVD may depend partly on the nature of products and may not apply to low-fat dairy foods. Increased circulating levels of inflammatory biomarkers after consumption of dairy product-rich meals suggest an association with CVD. In the present study, we tested the effects of low-fat and full-fat dairy diets on biomarkers associated with inflammation, oxidative stress or atherogenesis and on plasma lipid classes. Within full-fat dairy diets, we also compared fermented v. non-fermented products. In a randomised cross-over study, twelve overweight/obese subjects consumed during two 3-week periods two full-fat dairy diets containing either yogurt plus cheese (fermented) or butter, cream and ice cream (non-fermented) or a low-fat milk plus yogurt diet, with the latter being consumed between and at the end of the full-fat dairy dietary periods. The concentrations of six inflammatory and two atherogenic biomarkers known to be raised in CVD were measured as well as those of plasma F2-isoprostanes and lipid classes. The concentrations of six of the eight biomarkers tended to be higher on consumption of the low-fat dairy diet than on that of the fermented dairy diet and the concentrations of two plasmalogen lipid classes reported to be associated with increased oxidisability were also higher on consumption of the low-fat dairy diet than on that of the fermented dairy diet (P < 0.001), although plasma F2-isoprostane concentrations did not differ on consumption of any of the diets. On the other hand, the concentrations of plasma sphingomyelin and IL-6 were significantly higher on consumption of the non-fermented dairy diet than on that of the low-fat dairy diet (P < 0.02). In conclusion, short-term diets containing low-fat dairy products did not lead to a more favourable biomarker profile associated with CVD risk compared with the full-fat dairy products, suggesting that full-fat fermented dairy products may be the more favourable.
C1 [Nestel, Paul J.; Mellett, Natalie; Pally, Suzana; Wong, Gerard; Barlow, Chris K.; Meikle, Peter J.] Baker Heart & Diabet Inst, Melbourne, Vic, Australia.
   [Croft, Kevin; Mori, Trevor A.] Univ Western Australia, Sch Med & Pharmacol, Perth, WA 6009, Australia.
C3 Baker Heart and Diabetes Institute; University of Western Australia
RP Nestel, PJ (corresponding author), Baker Heart & Diabet Inst, Melbourne, Vic, Australia.
EM paul.nestel@bakeridi.edu.au
RI Croft, Kevin/C-4675-2013; Meikle, Peter/B-4023-2009; Mori,
   Trevor/H-5485-2014
OI Mori, Trevor A/0000-0002-5264-9229; Meikle, Peter/0000-0002-2593-4665;
   Croft, Kevin/0000-0003-1596-4913
FU Dairy Health and Nutrition Consortium
FX The following food companies provided partial support through the Dairy
   Health and Nutrition Consortium, with several of them providing bulk
   supplies of butter, cheese and ice cream: Bega Cheese/Tatura Milk
   Industries; Lion Dairy & Drinks; Fonterra Australia; Parmalat Australia;
   Murray Goulburn Co-operative; Warrnambool Cheese and Butter; Geoffrey
   Gardiner Foundation; Dairy Australia; Dairy Innovation Australia.We
   thank Sonja Middleton for dietetic advice. The authors' responsibilities
   are as follows: P. J. N. and P. J. M. were responsible for devising and
   conducting the study and for the writing of the manuscript; G. W. was
   responsible for the statistical analysis; K. C. and T. A. M. were
   responsible for the F2-isoprostane measurements and interpretation; S.
   P. was the research nurse and N. M. and C. K. B. were the laboratory
   scientists responsible for the measurements. The sponsor provided funds
   directly to the Institute. Author disclosures: P. J. M. and P. J. N.
   received grant-in-aid for the present study from the Dairy Health and
   Nutrition Consortium. N. M., S. P., G. W., C. K. B., K. C. and T. A. M.
   report no conflicts of interest.
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NR 35
TC 65
Z9 74
U1 2
U2 41
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1145
EI 1475-2662
J9 BRIT J NUTR
JI Br. J. Nutr.
PD DEC 28
PY 2013
VL 110
IS 12
BP 2242
EP 2249
DI 10.1017/S0007114513001621
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 298TC
UT WOS:000330346400015
PM 23756569
OA Bronze
DA 2025-06-11
ER

PT J
AU Shokri-Mashhadi, N
   Baechle, C
   Schiemann, T
   Schaefer, E
   Barbaresko, J
   Schlesinger, S
AF Shokri-Mashhadi, Nafiseh
   Baechle, Christina
   Schiemann, Tim
   Schaefer, Edyta
   Barbaresko, Janett
   Schlesinger, Sabrina
TI Effects of carotenoid supplementation on glycemic control: a systematic
   review and meta-analysis of randomized clinical trials
SO EUROPEAN JOURNAL OF CLINICAL NUTRITION
LA English
DT Review
ID TYPE-2 DIABETES-MELLITUS; METABOLIC SYNDROME; INSULIN-RESISTANCE;
   OXIDATIVE STRESS; DIETARY-INTAKE; DOSE-RESPONSE; RISK-FACTORS;
   ASTAXANTHIN; SAFFRON; CROCIN
AB ObjectivesWe conducted a systematic review and meta-analysis to assess the effects of carotenoid supplementation on glycemic indices, and the certainty of evidence.MethodsA systematic literature search in PubMed, SCOPUS, ISI-Web of Science, and Cochrane Library was conducted from inception up to Jun 17, 2024. Randomized controlled trials (RCTs) investigating the effect of carotenoid supplementation on circulating glycemic parameters were included. Records were excluded when studies reported the effect of co-interventions with other nutrients, did not provide mean differences (MDs) and standard deviations (SD) for outcomes, or administered whole food rather than supplements of carotenoids. Summary mean differences (MDs) and 95% CI between intervention and control groups were estimated using a random-effects model. The risk of bias of the included studies was assessed using the Risk of Bias 2.0 (RoB 2.0) tool.ResultsOverall, 36 publications with 45 estimated effect sizes were included in the meta-analyses. The overall findings showed an improvement in fasting blood glucose (FBG) (MD = -4.54 mg/dl; 95% CI: -5.9, -3.2; n = 45), and hemoglobin A1C (HbA1C) (MD = -0.25% (95% CI: -0.4, -0.11; n = 22) in the intervention group in comparison with the control group. Moreover, in individuals with type 2 diabetes (T2D), interventions with astaxanthin and fucoxanthin led to a reduction in FBG by 4.36 mg/dl (95% CI: -6.13, -2.6; n = 10). The findings also showed that the intervention with crocin reduced FBG levels by 13.5 mg/dl (95% CI: -15.5, -7.8; n = 5), and HbA1C by 0.55% (95% CI: -0.77, -0.34; n = 5) in individuals with T2D. However, the certainty of evidence was very low.ConclusionCarotenoid's supplementation improved glycemic parameters especially in people with T2D. However. the certainty of evidence was very low, mainly due to small sample size, and indirectness. Therefore, no specific recommendations can be provided at present and well-designed RCTs are required.Registry URLhttps://www.crd.york.ac.uk/PROSPERO/Registry numberCRD42021285084Registry and registry number for systematic reviews or meta-analysesPROSPERO ID: CRD42021285084
C1 [Shokri-Mashhadi, Nafiseh; Baechle, Christina; Schiemann, Tim; Schaefer, Edyta; Barbaresko, Janett; Schlesinger, Sabrina] Heinrich Heine Univ Dusseldorf, Inst Biometr & Epidemiol, German Diabet Ctr, Leibniz Ctr Diabet Res, Dusseldorf, Germany.
   [Shokri-Mashhadi, Nafiseh; Baechle, Christina; Schaefer, Edyta; Schlesinger, Sabrina] German Ctr Diabet Res DZD, Partner Dusseldorf, Dusseldorf, Germany.
   [Schiemann, Tim] Univ Bonn, Inst Nutr & Food Sci, Bonn, Germany.
C3 Heinrich Heine University Dusseldorf; Leibniz Association; Deutsches
   Diabetes-Zentrum (DDZ); German Center for Diabetes Research (DZD);
   University of Bonn
RP Shokri-Mashhadi, N (corresponding author), Heinrich Heine Univ Dusseldorf, Inst Biometr & Epidemiol, German Diabet Ctr, Leibniz Ctr Diabet Res, Dusseldorf, Germany.; Shokri-Mashhadi, N (corresponding author), German Ctr Diabet Res DZD, Partner Dusseldorf, Dusseldorf, Germany.
EM nafiseh.shokri@ddz.de
RI shokri-Mashhadi, nafiseh/AAU-5129-2020; Bächle, Christina/ABC-3136-2020;
   Schlesinger, Sabrina/AAE-7640-2020
OI Schlesinger, Sabrina/0000-0003-4244-0832
FU German Federal Ministry of Health; Ministry of Innovation, Science,
   Research, and Technology of the State North Rhine Westphalia; German
   Federal Ministry of Education and Research
FX The German Diabetes Center is funded by the German Federal Ministry of
   Health and the Ministry of Innovation, Science, Research, and Technology
   of the State North Rhine Westphalia. This study was also supported in
   part by a grant from the German Federal Ministry of Education and
   Research to the German Center for Diabetes Research. The funders had no
   role in the study design or in the collection, analysis, interpretation
   of data, writing of the report, or decision to submit the article for
   publication.
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NR 84
TC 0
Z9 0
U1 2
U2 3
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0954-3007
EI 1476-5640
J9 EUR J CLIN NUTR
JI Eur. J. Clin. Nutr.
PD MAR
PY 2025
VL 79
IS 2
BP 113
EP 125
DI 10.1038/s41430-024-01511-y
EA SEP 2024
PG 13
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA W3J8E
UT WOS:001320099600001
PM 39327454
DA 2025-06-11
ER

PT J
AU Moon, SW
   Kim, SY
   Jung, JY
   Kang, YA
   Park, MS
   Kim, YS
   Chang, J
   Ro, JS
   Lee, YH
   Lee, SH
AF Moon, Sung Woo
   Kim, Song Yee
   Jung, Ji Ye
   Kang, Young Ae
   Park, Moo Suk
   Kim, Young Sam
   Chang, Joon
   Ro, Jun Soo
   Lee, Yong-Ho
   Lee, Sang Hoon
TI Relationship between obstructive lung disease and non-alcoholic fatty
   liver disease in the Korean population: Korea National Health and
   Nutrition Examination Survey, 2007-2010
SO INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
LA English
DT Article
DE obstructive lung disease; non-alcoholic fatty liver disease;
   epidemiology; comorbidities
ID INSULIN-RESISTANCE; METABOLIC SYNDROME; ATHEROSCLEROSIS RISK;
   PULMONARY-DISEASE; OXIDATIVE STRESS; PREVALENCE; NAFLD; STEATOHEPATITIS;
   COMORBIDITIES; INTERLEUKIN-8
AB Purpose: Previous studies have shown that progressive forms of non-alcoholic fatty liver disease (NAFLD) occur frequently in patients with obstructive lung disease (OLD). However, few studies have written about this relationship. This study aimed to investigate the relationship between OLD and NAFLD.
   Subjects and methods: The Korea National Health and Nutrition Examination Survey is a national population-based, cross-sectional surveillance program that was initiated to assess the health and nutritional status of the Korean population. From 2007 to 2010, 11,738 subjects were enrolled. The subjects were defined as having NAFLD when they had scores higher than -0.640 in a NAFLD liver fat score prediction model, which was a previously validated prediction score. Individuals with forced expiratory volume in one second/forced vital capacity <0.7 were considered to have OLD. The subjects were divided into non-OLD and OLD groups and non-NAFLD and NAFLD groups. All analyses were performed using sample weighting using the complex samples plan.
   Results: The prevalences of NAFLD and OLD were 30.2% and 8.9%, respectively. Although not statistically significant, subjects in the NAFLD group involved a higher tendency of having OLD than did those in the non-NAFLD group (8.5% vs 10.0%, respectively, P=0.060). Subjects with OLD showed a higher tendency to have NAFLD than non-OLD subjects (30.0% vs 33.7%, respectively, P=0.060). NAFLD subjects were at higher odds of OLD (odds ratio=1.334; 95% confidence interval=1.108-1.607, P=0.002) than non-NAFLD subjects, after adjusting for age, sex, and smoking history. OLD subjects were at higher odds of NAFLD (odds ratio=1.556; 95% confidence interval=1.288-1.879, P<0.001) than non-OLD subjects, after adjusting for age, sex, and smoking history.
   Conclusion: This study showed that NAFLD is related to OLD. Clinicians should be aware of possible liver comorbidities in OLD patients and that extrahepatic disease in NAFLD patients may vary more than previously thought.
C1 [Moon, Sung Woo; Kim, Song Yee; Jung, Ji Ye; Kang, Young Ae; Park, Moo Suk; Kim, Young Sam; Chang, Joon; Lee, Sang Hoon] Yonsei Univ, Coll Med, Severance Hosp, Div Pulm Med,Dept Internal Med,Inst Chest Dis, 50-1 Yonsei Ro, Seoul 120752, South Korea.
   [Ro, Jun Soo] Seoul Natl Univ, Bundang Hosp, Ctr Prevent Med & Publ Hlth, Seongnam Si, Gyeonggi Do, South Korea.
   [Lee, Yong-Ho] Yonsei Univ, Coll Med, Severance Hosp, Div Endocrinol,Dept Internal Med, Seoul, South Korea.
   [Lee, Sang Hoon] Seoul Natl Univ, Bundang Hosp, Div Pulm & Crit Care Med, Dept Internal Med, Seongnam Si, Gyeonggi Do, South Korea.
C3 Yonsei University; Yonsei University Health System; Seoul National
   University (SNU); Yonsei University; Yonsei University Health System;
   Seoul National University (SNU)
RP Lee, SH (corresponding author), Yonsei Univ, Coll Med, Severance Hosp, Div Pulm Med,Dept Internal Med,Inst Chest Dis, 50-1 Yonsei Ro, Seoul 120752, South Korea.
EM tearpoem9@gmail.com
RI Moon, Sungwoo/MAI-5006-2025; Park, Moo Suk/N-3531-2018; Lee,
   Sang-Hoon/ABH-6210-2020; Jung, Ji/AAB-4993-2021; Kim, Yoon/G-6633-2015;
   Lee, Yong-ho/AAT-4106-2020; Kim, Sun/GSN-4867-2022
OI Kim, Young Sam/0000-0001-9656-8482; Kang, Young Ae/0000-0002-7783-5271;
   Chang, Joon/0000-0003-4542-6841; Park, Moo Suk/0000-0003-0820-7615; Ro,
   Jun-soo/0000-0002-8156-5294; Lee, Sang Hoon/0000-0002-7706-5318; Kim,
   Song Yee/0000-0001-8627-486X; Moon, Sung Woo/0000-0001-9917-9802; Lee,
   Yong-ho/0000-0002-6219-4942; Jung, Ji Ye/0000-0003-1589-4142
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NR 39
TC 23
Z9 23
U1 0
U2 2
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-2005
J9 INT J CHRONIC OBSTR
JI Int. J. Chronic Obstr. Pulm. Dis.
PY 2018
VL 13
BP 2603
EP 2611
DI 10.2147/COPD.S166902
PG 9
WC Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Respiratory System
GA GR7WU
UT WOS:000442909800001
PM 30214178
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Tatsch, E
   De Carvalho, JAM
   Hausen, BS
   Bollick, YS
   Torbitz, VD
   Duarte, T
   Scolari, R
   Duarte, MMMF
   Londero, SWK
   Vaucher, RA
   Premaor, MO
   Comim, FV
   Moresco, RN
AF Tatsch, Etiane
   De Carvalho, Jose A. M.
   Hausen, Bruna S.
   Bollick, Yanai S.
   Torbitz, Vanessa D.
   Duarte, Thiago
   Scolari, Rogerio
   Duarte, Marta M. M. F.
   Londero, Silvia W. K.
   Vaucher, Rodrigo A.
   Premaor, Melissa O.
   Comim, Fabio V.
   Moresco, Rafael N.
TI Oxidative DNA damage is associated with inflammatory response, insulin
   resistance and microvascular complications in type 2 diabetes
SO MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
LA English
DT Article
DE Type 2 diabetes; DNA damage; Inflammation; Insulin resistance
ID GLYCATION END-PRODUCTS; PROTEIN PRODUCTS; URINARY
   8-HYDROXYDEOXYGUANOSINE; VASCULAR COMPLICATIONS; GENE POLYMORPHISMS;
   METABOLIC SYNDROME; CELL-FUNCTION; MELLITUS; STRESS; MECHANISMS
AB Urinary markers of nucleic acid oxidation may be useful biomarkers in diabetes. It has been demonstrated that T2DM patients have an increased level of oxidative DNA damage; however, it is unclear whether increased DNA damage may be related to a greater degree of inflammation and insulin resistance. Thus, the aim of this present study was to investigate the relation of the impact of oxidative DNA damage, assessed by urinary 8-OHdG, on the levels of inflammatory cytokines, as well as insulin resistance. In addition, we also investigated the diagnostic ability of urinary 8-OHdG in the identification of microvascular complications in T2DM.A case-control study, enrolling 22 healthy controls and 54 subjects with T2DM, was performed to evaluate the relation between oxidative DNA damage and interleukin-6 (IL-6), IL-1,tumor necrosis factor-alpha (TNF-alpha), IL-10, and Homeostasis Model Assessment (HOMA-IR) index. T2DM patients presented higher urinary 8-OHdG, IL-6, IL-1, TNF-alpha levels and HOMA-IR, and lower IL-10 levels than control subjects. Moreover, urinary 8-OHdG levels were significantly higher in the group T2DM with microvascular complications when compared to the without complications. The areas under the curve for urinary 8-OHdG and urinary albumin were, respectively, 0.836 (P<0.001) and 0.786 (P=0.002). Thus, urinary 8-OHdG has a slightly higher ability to discriminate microvascular complications in T2DM compared with urinary albumin. It was also demonstrated that T2DM patients with higher median of urinary 8-OHdG had significantly elevated levels of IL-6, TNF-alpha and HOMA-IR, and decreased IL-10 levels. Our findings showed that T2DM patients with higher urinary 8-OHdG levels showed a greater inflammatory degree and higher insulin resistance. It is possible to speculate that T2DM patients present a cascade of events as increasing metabolic abnormalities such as insulin resistance and inflammatory activation, as well as increased ROS generation factors that may contribute directly to greater oxidative DNA damage. (C) 2015 Elsevier B.V. All rights reserved.
C1 [Tatsch, Etiane; De Carvalho, Jose A. M.; Hausen, Bruna S.; Bollick, Yanai S.; Torbitz, Vanessa D.; Moresco, Rafael N.] Univ Fed Santa Maria, Ctr Hlth Sci, Dept Clin & Toxicol Anal, Lab Clin Biochem, BR-97105900 Santa Maria, RS, Brazil.
   [De Carvalho, Jose A. M.; Londero, Silvia W. K.] Univ Hosp, Santa Maria, RS, Brazil.
   [Duarte, Thiago] Univ Fed Santa Maria, Ctr Hlth Sci, Lab Biogen, BR-97105900 Santa Maria, RS, Brazil.
   [Scolari, Rogerio; Duarte, Marta M. M. F.] Labimed Clin Chem & Med Lab, Santa Maria, RS, Brazil.
   [Duarte, Marta M. M. F.] Univ Luterana Brasil, Dept Hlth Sci, Santa Maria, RS, Brazil.
   [Vaucher, Rodrigo A.] UNIFRA, Franciscan Univ Ctr, Microbiol Lab, Santa Maria, RS, Brazil.
   [Premaor, Melissa O.; Comim, Fabio V.] Univ Fed Santa Maria, Ctr Hlth Sci, Dept Clin Med, BR-97105900 Santa Maria, RS, Brazil.
C3 Universidade Federal de Santa Maria (UFSM); Universidade Federal de
   Santa Maria (UFSM); Universidade Luterana do Brasil; Universidade
   Federal de Santa Maria (UFSM)
RP Moresco, RN (corresponding author), Univ Fed Santa Maria, Ctr Ciencias Saude, Dept Anal Clin & Toxicol, Ave Roraima 1000,Predio 26,Sala 1401, BR-97105900 Santa Maria, RS, Brazil.
EM rnmoresco@ufsm.br
RI de Carvalho, José/F-9418-2015; Comim, Fabio/L-1298-2015; Premaor,
   Melissa/K-7401-2016; Moresco, Rafael/K-6118-2017
OI Premaor, Melissa/0000-0002-0770-9202; Moresco,
   Rafael/0000-0003-3072-5080; Vasconcellos Comim,
   Fabio/0000-0002-2726-233X; VAUCHER, RODRIGO/0000-0002-8306-9243
FU National Council for Scientific and Technological Development (CNPq,
   Brazil); Capes Foundation (Brazil)
FX This study was supported by scholarships from the National Council for
   Scientific and Technological Development (CNPq, Brazil) and Capes
   Foundation (Brazil). The authors thank Bioclin/Quibasa (Belo Horizonte,
   Brazil) and Laborsys (Porto Alegre, Brazil) for providing biochemical
   reagents. We also thank the team of the Clinical Analysis Laboratory
   (LAC) of the University Hospital of Santa Maria for the support
   provided.
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NR 52
TC 46
Z9 48
U1 0
U2 16
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0027-5107
EI 1873-135X
J9 MUTAT RES-FUND MOL M
JI Mutat. Res.-Fundam. Mol. Mech. Mutagen.
PD DEC
PY 2015
VL 782
BP 17
EP 22
DI 10.1016/j.mrfmmm.2015.10.003
PG 6
WC Biotechnology & Applied Microbiology; Genetics & Heredity; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Genetics & Heredity; Toxicology
GA CZ3SE
UT WOS:000367023500003
PM 26520687
DA 2025-06-11
ER

PT J
AU Bender, SB
   McGraw, AP
   Jaffe, IZ
   Sowers, JR
AF Bender, Shawn B.
   McGraw, Adam P.
   Jaffe, Iris Z.
   Sowers, James R.
TI Mineralocorticoid Receptor-Mediated Vascular Insulin Resistance An Early
   Contributor to Diabetes-Related Vascular Disease?
SO DIABETES
LA English
DT Article
ID SMOOTH-MUSCLE-CELLS; ANGIOTENSIN-II; ENDOTHELIAL FUNCTION;
   HEART-FAILURE; ALDOSTERONE PRODUCTION; MYOCARDIAL-INFARCTION;
   GENE-TRANSCRIPTION; OXIDATIVE STRESS; SKELETAL-MUSCLE; APOE(-/-) MICE
AB Two-thirds of adults in the U.S. are overweight or obese, and another 26 million have type 2 diabetes (T2D). Patients with diabetes and/or the metabolic syndrome have a significantly increased risk of heart attack and stroke compared with people with normal insulin sensitivity. Decreased insulin sensitivity in cardiovascular tissues as well as in traditional targets of insulin metabolic signaling, such as skeletal muscle, is an underlying abnormality in obesity, hypertension, and T2D. In the vasculature, insulin signaling plays a critical role in normal vascular function via endothelial cell nitric oxide production and modulation of Ca2+ handling and sensitivity in vascular smooth muscle cells. Available evidence suggests that impaired vascular insulin sensitivity may be an early, perhaps principal, defect of vascular function and contributor to the pathogenesis of vascular disease in persons with obesity, hypertension, and T2D. In the overweight and obese individual, as well as in persons with hypertension, systemic and vascular insulin resistance often occur in concert with elevations in plasma aldosterone. Indeed, basic and clinical studies have demonstrated that elevated plasma aldosterone levels predict the development of insulin resistance and that aldosterone directly interferes with insulin signaling in vascular tissues. Furthermore, elevated plasma aldosterone levels are associated with increased heart attack and stroke risk. Conversely, renin-angiotensin-aldosterone system and mineralocorticoid receptor (MR) antagonism reduces cardiovascular risk in these patient populations. Recent and accumulating evidence in this area has implicated excessive Ser phosphorylation and proteosomal degradation of the docking protein, insulin receptor substrate, and enhanced signaling through hybrid insulin/IGF-1 receptor as important mechanisms underlying aldosterone-mediated interruption of downstream vascular insulin signaling. Prevention or restoration of these changes via blockade of aldosterone action in the vascular wall with MR antagonists (i.e., spironolactone, eplerenone) may therefore account for the clinical benefit of these compounds in obese and diabetic patients with cardiovascular disease. This review will highlight recent evidence supporting the hypothesis that aldosterone and MR signaling represent an ideal candidate pathway linking early promoters of diabetes, especially overnutrition and obesity, to vascular insulin resistance, dysfunction, and disease. Diabetes 62:313-319, 2013
C1 [Bender, Shawn B.; Sowers, James R.] Univ Missouri, Sch Med, Dept Internal Med, Columbia, MO 65211 USA.
   [Bender, Shawn B.; Sowers, James R.] Harry S Truman VA Med Ctr, Diabet & Cardiovasc Ctr, Columbia, MO USA.
   [McGraw, Adam P.; Jaffe, Iris Z.] Mol Cardiol Res Inst, Tufts Med Ctr, Boston, MA USA.
   [Sowers, James R.] Univ Missouri, Sch Med, Dept Med Pharmacol & Physiol, Columbia, MO USA.
C3 University of Missouri System; University of Missouri Columbia;
   University of Missouri System; University of Missouri Columbia; US
   Department of Veterans Affairs; Veterans Health Administration (VHA);
   Harry S. Truman Memorial Veterans' Hospital; Tufts Medical Center;
   University of Missouri System; University of Missouri Columbia
RP Bender, SB (corresponding author), Univ Missouri, Sch Med, Dept Internal Med, Columbia, MO 65211 USA.
EM benders@health.missouri.edu
FU National Institutes of Health [HL-073101, HL-107910, HL-095590];
   Veterans Affairs Merit System [0018]
FX This work was supported by grants from the National Institutes of Health
   (HL-073101 and HL-107910 to J.R.S. and HL-095590 to I.Z.J.) and the
   Veterans Affairs Merit System (0018 to J.R.S.).
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NR 50
TC 131
Z9 133
U1 0
U2 27
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0012-1797
J9 DIABETES
JI Diabetes
PD FEB
PY 2013
VL 62
IS 2
BP 313
EP 319
DI 10.2337/db12-0905
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 080SM
UT WOS:000314263600001
PM 23349535
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Pengnet, S
   Sumarithum, P
   Phongnu, N
   Prommaouan, S
   Kantip, N
   Phoungpetchara, I
   Malakul, W
AF Pengnet, Sirinat
   Sumarithum, Phinsuda
   Phongnu, Nuttaphong
   Prommaouan, Sakdina
   Kantip, Napapas
   Phoungpetchara, Ittipon
   Malakul, Wachirawadee
TI Naringin attenuates fructose-induced NAFLD progression in rats through
   reducing endogenous triglyceride synthesis and activating the Nrf2/HO-1
   pathway
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Article
DE naringin; fructose; non-alcoholic fatty liver disease; inflammation; de
   novo lipogenesis
ID AMELIORATES ENDOTHELIAL DYSFUNCTION; FATTY LIVER-DISEASE; HEPATIC
   STEATOSIS; OXIDATIVE STRESS; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   ANTIOXIDANT; CARBOHYDRATE; FIBROSIS; EXTRACT
AB Background: Excessive fructose consumption causes hepatic lipid accumulation via increased triglyceride (TG) synthesis, leading to the development and progression of non-alcoholic fatty liver disease (NALFD). Naringin, a flavanone glycoside found in citrus fruit, has antioxidant and hypolipidemic properties. Therefore, the aim of this study was to investigate the effect of naringin on fructose-induced NAFLD in rats and the possible underlying mechanism. Methods: Male Sprague Dawley rats were given 10% (w/v) fructose in drinking water for 12 weeks. Naringin (100 mg/kg/day) was administered orally to rats for the last 4 weeks of fructose overload. After 12 weeks of treatment, the hepatic lipid content was determined. In addition, the expression of proteins involved in de novo lipogenesis (DNL) and TG synthesis as well as antioxidant and inflammatory mediators in the liver were examined by western blot analysis. Results: Treatment of fructose-fed rats with naringin significantly decreased the hepatic TG and cholesterol content as well as serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) activities. Naringin treatment also decreased the hepatic expression of carbohydrate response element binding protein (ChREBP), sterol regulatory element-binding protein-1c (SREBP-1c) and nuclear SREBP-1c (nSREBP-1c) as well as enzymes involved in DNL (acetyl CoA carboxylase [ACC] and fatty acid synthase [FAS]) and an enzyme involved in TG synthesis (glycerol-3-phosphate acyltransferase 1 [GPAT-1] and diacylglycerol acyltransferase2 [DGAT2]) in fructose-fed rats. In addition, naringin induced a significant decrease in the hepatic expression of nuclear factor kappa B (NF-kappa B) and tumor necrosis factor alpha (TNF-alpha). Furthermore, naringin administration restored the expression of the antioxidant mediators nuclear factor (erythroid-derived 2)-like 2 (Nrf2) and heme oxygenase-1 (HO-1) in the liver of fructose-fed rats. Conclusion: These results demonstrate that oral administration of naringin protects against fructose-induced hepatic steatosis by decreasing DNL and TG synthesis. In addition, naringin could prevent NAFLD progression via targeting the Nrf2/HO-1 and the NF-kappa B/TNF-alpha pathways.
C1 [Pengnet, Sirinat] Univ Phayao, Sch Med Sci, Div Physiol, Phayao, Thailand.
   [Sumarithum, Phinsuda; Phongnu, Nuttaphong; Prommaouan, Sakdina; Kantip, Napapas; Malakul, Wachirawadee] Naresuan Univ, Fac Med Sci, Dept Physiol, Phitsanulok, Thailand.
   [Phoungpetchara, Ittipon] Naresuan Univ, Fac Med Sci, Dept Anat, Phitsanulok, Thailand.
   [Malakul, Wachirawadee] Naresuan Univ, Ctr Excellence Med Biotechnol, Phitsanulok, Thailand.
C3 University of Phayao; Naresuan University; Naresuan University; Naresuan
   University
RP Malakul, W (corresponding author), Naresuan Univ, Fac Med Sci, Dept Physiol, Phitsanulok, Thailand.; Malakul, W (corresponding author), Naresuan Univ, Ctr Excellence Med Biotechnol, Phitsanulok, Thailand.
EM wachirawadeema@nu.ac.th
RI Malakul, Wachirawadee/GQQ-6452-2022
OI Malakul, Wachirawadee/0000-0002-1677-2086
FU National Research Council of Thailand; Thailand Science Research and
   Innovation fund [R2561B030]; University of Phayao (SIP);  [FF64-RIM039]
FX The present study was supported by the National Research Council of
   Thailand (Grant no. R2561B030, WM), and partially supported by the
   Thailand Science Research and Innovation fund and The University of
   Phayao (Grant No. FF64-RIM039, SIP).
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NR 60
TC 12
Z9 13
U1 10
U2 18
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD DEC 15
PY 2022
VL 13
AR 1049818
DI 10.3389/fphar.2022.1049818
PG 14
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 7K5SV
UT WOS:000905343400001
PM 36588703
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Hong, SH
   Kim, M
   Woo, M
   Song, YO
AF Hong, Sun Hee
   Kim, Mijeong
   Woo, Minji
   Song, Yeong Ok
TI Effects of ingredients of Korean brown rice cookies on attenuation of
   cholesterol level and oxidative stress in high-fat diet-fed mice
SO NUTRITION RESEARCH AND PRACTICE
LA English
DT Article
DE Antioxidants; lipid metabolism; SREBP2 Protein; ginseng; inflammation
ID ACTIVATED PROTEIN-KINASE; RED GINSENG; METABOLIC SYNDROME;
   PANAX-GINSENG; ANIMAL-TISSUES; HEPG2 CELLS; OBESE MICE; RATS; LIVER;
   7-ALPHA-HYDROXYLASE
AB BACKGROUND/OBJECTIVES: Owing to health concerns related to the consumption of traditional snacks high in sugars and fats, much effort has been made to develop functional snacks with low calorie content. In this study, a new recipe for Korean rice cookie, dasik, was developed and its antioxidative, lipid-lowering, and anti-inflammatory effects and related mechanisms were elucidated. The effects were compared with those of traditional rice cake dasik (RCD), the lipid-lowering effect of which is greater than that of traditional western-style cookies.
   MATERIALS/METHODS: Ginseng-added brown rice dasik (GBRD) was prepared with brown rice flour, fructooligosaccharide, red ginseng extract, and propolis. Mice were grouped (n = 7 per group) into those fed a normal AIN-76 diet, a high-fat diet (HFD), and HFD supplemented with RCD or GBRD. Dasik in the HFD accounted for 7% of the total calories. The lipid, reactive oxygen species, and peroxynitrite levels, and degree of lipid peroxidation in the plasma or liver were determined. The expression levels of proteins involved in lipid metabolism and inflammation, and those of antioxidant enzymes were determined by western blot analysis.
   RESULTS: The plasma and hepatic total cholesterol concentrations in the GBRD group were significantly decreased via downregulation of sterol regulatory element-binding protein-2 and 3-hydroxy-3-methylglutaryl-CoA reductase (P < 0.05). The hepatic peroxynitrite level was significantly lower, whereas glutathione was higher, in the GBRD group than in the RCD group. Among the antioxidant enzymes, catalase (CAT) and glutathione peroxidase (GPx) were significantly upregulated in the GBRD group (P < 0.05). In addition, nuclear factor-kappaB (NF-kappa B) expression in the GBRD group was significantly lower than that in the RCD group.
   CONCLUSIONS: GBRD decreases the plasma and hepatic cholesterol levels by downregulating cholesterol synthesis. This new dasik recipe also improves the antioxidative and anti-inflammatory status in HFD:fed mice via CAT and GPx upregulation and NF-kappa B downregulation. These effects were significantly higher than those of RCD.
C1 [Song, Yeong Ok] Pusan Natl Univ, Dept Food Sci & Nutr, 2 Busandaehak Ro 63 Beon Gil, Busan 46241, South Korea.
   Pusan Natl Univ, Kimchi Res Inst, 2 Busandaehak Ro 63 Beon Gil, Busan 46241, South Korea.
C3 Pusan National University; Pusan National University
RP Song, YO (corresponding author), Pusan Natl Univ, Dept Food Sci & Nutr, 2 Busandaehak Ro 63 Beon Gil, Busan 46241, South Korea.
EM yosong@pusan.ac.kr
FU iPET (Korea Institute of Planning and Evaluation for Technology in Food,
   Agriculture, Forestry and Fisheries), Ministry of Agriculture, Food and
   Rural Affairs [911040-1]
FX This research was supported by Superiority and Functionality of Hansik
   (Korean Food) Research Program (#911040-1), iPET (Korea Institute of
   Planning and Evaluation for Technology in Food, Agriculture, Forestry
   and Fisheries), Ministry of Agriculture, Food and Rural Affairs.
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NR 46
TC 3
Z9 3
U1 0
U2 16
PU KOREAN NUTRITION SOC
PI SEOUL
PA 804 KST CTR, 635-4 YEOGSAM-SONG KANGNAM-KU, SEOUL, 135-703, SOUTH KOREA
SN 1976-1457
EI 2005-6168
J9 NUTR RES PRACT
JI Nutr. Res. Pract.
PD OCT
PY 2017
VL 11
IS 5
BP 365
EP 372
DI 10.4162/nrp.2017.11.5.365
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA FK3NK
UT WOS:000413391600002
PM 28989572
OA Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Wang, LX
   Liu, K
   Gao, DW
   Hao, JK
AF Wang, Li-Xin
   Liu, Kai
   Gao, Da-Wei
   Hao, Ji-Kui
TI Protective effects of two Lactobacillus plantarum strains in
   hyperlipidemic mice
SO WORLD JOURNAL OF GASTROENTEROLOGY
LA English
DT Article
DE Lactobacillus plantarum; Hypolipidemic; Nuclear factor erythroid
   2-related factor 2; Metabolic syndrome; Hepatic steatosis;
   Cardiovascular disease
ID LACTIC-ACID BACTERIA; OXIDATIVE STRESS; CHOLESTEROL; PLASMA; EXTRACT;
   CASEI; L.
AB AIM: To investigate the effects of Lactobacillus plantarum (L. plantarum) CAI6 and L. plantarum SC4 on hyperlipidemic mice.
   METHODS: Male Kunming mice were fed a high-cholesterol diet for 28 d to construct hyperlipidemic models. Hyperlipidemic mice and normal mice were assigned to 3 groups which were separately treated with L. plantarum CAI6, L. plantarum SC4, and physiological saline through oral gavage for 28 d. Total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) levels were measured by commercially available enzyme kits. FACS Calibur flow cytometry was used to examine hepatic and renal nuclear factor-erythroid 2-related factor 2 (Nrf2) expression. The morphology of livers was checked by hematoxylin and eosin staining and optical microscope observation.
   RESULTS: Compared with normal mice, hyperlipidemic mice possessed significantly higher TC (3.50 +/- 0.43 vs 2.89 +/- 0.36, P < 0.01), TG (1.76 +/- 0.07 vs 1.10 +/- 0.16, P < 0.01), and LDL-C (1.72 +/- 0.20 vs 0.82 +/- 0.10, P < 0.01) levels, resulting in an increase of atherogenic index (AI) (2.34 +/- 1.60 vs 0.93 +/- 0.55, P < 0.05) and LDL-C/HDL-C ratio (1.43 +/- 0.12 vs 0.51 +/- 0.16, P < 0.05). After treatment with L. plantarum CAI6/L. plantarum SC4, TG (1.43 +/- 0.27/1.54 +/- 0.10 vs 1.76 +/- 0.07, P < 0.01/P < 0.05) and LDL-C (1.42 +/- 0.07/1.47 +/- 0.12 vs 1.72 +/- 0.20, P < 0.01/P < 0.01) in hyperlipidemic mice significantly decreased. In addition, TC, HDL-C, AI, and LDL-C/HDL-C ratio were all positively changed. Meanwhile, the treatment markedly alleviated hepatic steatosis and significantly stimulated Nrf2 expression (73.79 +/- 0.80/72.96 +/- 1.22 vs 54.94 +/- 1.84, P < 0.01/P < 0.01) in hepatocytes of hyperlipidemic mice.
   CONCLUSION: L. plantarum CAI6 and L. plantarum SC4 may protect against cardiovascular disease by lipid metabolism regulation and Nrf2-induced antioxidative defense in hyperlipidemic mice. (C) 2013 Baishideng. All rights reserved.
C1 [Wang, Li-Xin; Liu, Kai; Gao, Da-Wei] Yanshan Univ, Dept Biol Engn, Coll Environm & Chem Engn, Qinhuangdao 066004, Hebei Province, Peoples R China.
   [Hao, Ji-Kui] IIT, Dept Chem & Biol Engn, Armour Coll Engn, Chicago, IL 60616 USA.
C3 Yanshan University; Illinois Institute of Technology
RP Gao, DW (corresponding author), Yanshan Univ, Dept Biol Engn, Coll Environm & Chem Engn, 438 Hebei St, Qinhuangdao 066004, Hebei Province, Peoples R China.
EM dwgao@ysu.edu.cn
RI Liu, Kai/I-9041-2016; Stefanadis, Christodoulos/ABH-2232-2020
OI Liu, Kai/0000-0002-8233-2310; Stefanadis,
   Christodoulos/0000-0001-5974-6454
FU Chinese Ministry of Education Doctor Degree grant [20101333120011];
   Hebei Province Natural Science Fund [C2011203137, 11965152D]; Chinese
   Postdoctoral grant [480013]
FX Supported by Chinese Ministry of Education Doctor Degree grant, No.
   20101333120011; Hebei Province Natural Science Fund, No. C2011203137 and
   No. 11965152D; Chinese Postdoctoral grant, No. 480013
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NR 34
TC 55
Z9 55
U1 0
U2 34
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 7041 Koll Center Parkway, Suite 160, PLEASANTON, CA, UNITED STATES
SN 1007-9327
EI 2219-2840
J9 WORLD J GASTROENTERO
JI World J. Gastroenterol.
PD MAY 28
PY 2013
VL 19
IS 20
BP 3150
EP 3156
DI 10.3748/wjg.v19.i20.3150
PG 7
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 157BB
UT WOS:000319869200021
PM 23716997
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Guarano, A
   Capozzi, A
   Cristodoro, M
   Di Simone, N
   Lello, S
AF Guarano, Alice
   Capozzi, Anna
   Cristodoro, Martina
   Di Simone, Nicoletta
   Lello, Stefano
TI Alpha Lipoic Acid Efficacy in PCOS Treatment: What Is the Truth?
SO NUTRIENTS
LA English
DT Review
DE alpha lipoic acid; polycystic ovary syndrome; insulin resistance;
   chronic inflammation; insulin-sensitizing factors
ID POLYCYSTIC-OVARY-SYNDROME; D-CHIRO-INOSITOL; ACTIVATED PROTEIN-KINASE;
   LUTEINIZING-HORMONE; INSULIN SENSITIVITY; GRANULOSA-CELLS; ANOVULATORY
   WOMEN; OXIDATIVE STRESS; MEIOTIC SPINDLE; GLUCOSE-UPTAKE
AB Polycystic ovary syndrome (PCOS) is among the most common female endocrinopathies, affecting about 4-25% of women of reproductive age. Women affected by PCOS have an increased risk of developing metabolic syndrome, type 2 diabetes mellitus, cardiovascular diseases, and endometrial cancer. Given the pivotal role of insulin resistance (IR) in the pathogenesis of PCOS, in the last years, many insulin-sensitizing factors have been proposed for PCOS treatment. The first insulin sensitizer recommended by evidence-based guidelines for the assessment and treatment of PCOS was metformin, but the burden of side effects is responsible for treatment discontinuation in many patients. Inositols have insulin-mimetic properties and contribute to decreasing postprandial blood glucose, acting by different pathways. ALA is a natural amphipathic compound with a very strong anti-inflammatory and antioxidant effect and a very noteworthy role in the improvement of insulin metabolic pathway. Given the multiple effects of ALA, a therapeutic strategy based on the synergy between inositols and ALA has been recently proposed by many groups with the aim of improving insulin resistance, reducing androgen levels, and ameliorating reproductive outcomes in PCOS patients. The purpose of this study is to review the existing literature and to evaluate the existing data showing the efficacy and the limitation of a treatment strategy based on this promising molecule. ALA is a valid therapeutic strategy applicable in the treatment of PCOS patients: Its multiple actions, including antinflammatory, antioxidant, and insulin-sensitizing, may be of utmost importance in the treatment of a very complex syndrome. Specifically, the combination of MYO plus ALA creates a synergistic effect that improves insulin resistance in PCOS patients, especially in obese/overweight patients with T2DM familiarity. Moreover, ALA treatment also exerts beneficial effects on endocrine patterns, especially if combined with MYO, improving menstrual regularity and ovulation rhythm. The purpose of our study is to review the existing literature and to evaluate the data showing the efficacy and the limitations of a treatment strategy based on this promising molecule.
C1 [Guarano, Alice; Cristodoro, Martina; Di Simone, Nicoletta] Humanitas Univ, Dept Biomed Sci, Via Rita Levi Montalcini 4, I-20072 Milan, Italy.
   [Guarano, Alice] Humanitas San Pio X, Via Francesco Nava 31, I-20159 Milan, Italy.
   [Capozzi, Anna; Lello, Stefano] Fdn Policlin Univ Agostino Gemelli, Ist Ricovero & Cura Carattere Sci IRCCS, Dipartimento Sci Salute Donna Bambino & Sanita Pub, Largo Agostino Gemelli 8, I-00168 Rome, Italy.
   [Cristodoro, Martina; Di Simone, Nicoletta] IRCCS Humanitas Res Hosp, Via Manzoni 56, I-20089 Milan, Italy.
C3 Humanitas University; Catholic University of the Sacred Heart; IRCCS
   Policlinico Gemelli
RP Di Simone, N (corresponding author), Humanitas Univ, Dept Biomed Sci, Via Rita Levi Montalcini 4, I-20072 Milan, Italy.; Di Simone, N (corresponding author), IRCCS Humanitas Res Hosp, Via Manzoni 56, I-20089 Milan, Italy.
EM alice.guarano@sanpiox.humanitas.it;
   anna.capozzi@guest.policlinicogemelli.it;
   martina.cristodoro@st.hunimed.eu; nicoletta.disimone@hunimed.eu;
   lello.stefano@gmail.com
RI Lello, Stefano/ADU-2239-2022; Capozzi, Anna/AAF-2793-2019; Di Simone,
   Nicoletta/ACK-1974-2022
OI Capozzi, Anna/0000-0003-0488-1215; DI SIMONE,
   NICOLETTA/0000-0003-1273-3335
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NR 75
TC 8
Z9 8
U1 0
U2 4
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JUL
PY 2023
VL 15
IS 14
AR 3209
DI 10.3390/nu15143209
PG 13
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA N5RS3
UT WOS:001037588100001
PM 37513627
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Rojas, MM
   Villalpando, DM
   Ferrer, M
   Alexander-Aguilera, A
   García, HS
AF Margot Rojas, Mibsam
   Maria Villalpando, Diva
   Ferrer, Mercedes
   Alexander-Aguilera, Alfonso
   Sergio Garcia, Hugo
TI Conjugated Linoleic Acid Supplemented Diet Influences Serum Markers in
   Orchidectomized Sprague-Dawley Rats
SO EUROPEAN JOURNAL OF LIPID SCIENCE AND TECHNOLOGY
LA English
DT Article
DE conjugated linoleic acid; orchidectomy; serum markers; sex hormones
ID CHRONIC KIDNEY-DISEASE; CARDIOVASCULAR-DISEASE; ENDOTHELIAL DYSFUNCTION;
   HEART-DISEASE; PLASMA-LIPIDS; TESTOSTERONE; INCREASES; LIVER;
   POPULATION; METABOLISM
AB Conjugated isomers of linoleic acid have beneficial effects on human health, with demonstrated anticarcinogenic, antiatherogenic, antioxidant, and anti-inflammatory properties. Previous studies have shown that the loss of sex hormones induced by orchidectomy affects vascular function and serum lipids. The objective of this work is to evaluate the effect of conjugated linoleic acid (CLA) on serum lipids, cardiac, renal, and hepatic markers in orchidectomized Sprague-Dawley rats. Male sex hormone deprivation is induced by orchidectomy to 24-week-old rats. The rats are fed a diet containing 1.8% w/w CLA, or a control diet for 8 weeks. At the end of the treatment, serum markers are measured using commercially available kits. The concentrations found in the orchidectomized-CLA (ORX-CLA) group of total cholesterol, low-density lipoproteins (LDL), as well as the atherogenic index, concentrations of creatine kinase, lactate dehydrogenase, C-reactive protein, glucose, urea, uric acid, creatinine, albumin, calcium, total protein, and bilirubin are significantly lower compared to the orchidectomized-control (ORX-C) group. The concentrations of high-density lipoproteins (HDL), calcium, total protein, albumin, total bilirubin, and indirect bilirubin are significantly higher in the ORX-CLA group than in the ORX-C group. The CLA-supplemented diet exerts a beneficial effect on different biochemical parameters negatively affected by orchidectomy, which may result in vascular protection. Practical Applications: The relationship between testosterone deficiency and the alteration of serum lipids is demonstrated; however, it is demonstrated in this study that the markers of renal damage, cardiac damage, and oxidative stress are also negatively affected by the lack of this hormone. This information has enriched the understanding about the relationship between testosterone deficiency and the development of different diseases such as metabolic syndrome, type 2 diabetes, kidney failure, osteoporosis, cardiovascular diseases, and cancer. On the other hand, CLA has been studied mainly as a nutraceutical and sports supplement; the information in this study will help to expand the knowledge about the benefits of these isomers of linoleic acid, providing guidelines for its use as a protection against negative effects triggered by orchidectomy.
C1 [Margot Rojas, Mibsam; Sergio Garcia, Hugo] UNIDA, Tecnol Nacl Mexico, Inst Tecnol Veracruz, MA de Quevedo 2779, Xalapa 91897, Veracruz, Mexico.
   [Maria Villalpando, Diva; Ferrer, Mercedes] Univ Autonoma Madrid, Fac Med, Dept Fisiol, C Arzobispo Morcillo 4, E-28049 Madrid 28029, Spain.
   [Ferrer, Mercedes] Hosp Univ La Paz IdiPAZ, Inst Invest, Madrid, Spain.
   [Alexander-Aguilera, Alfonso] Univ Veracruzana, Fac Bioanal, Carmen Serdan S-N, Xalapa 91700, Veracruz, Mexico.
C3 Autonomous University of Madrid; Hospital Universitario La Paz;
   Universidad Veracruzana
RP García, HS (corresponding author), UNIDA, Tecnol Nacl Mexico, Inst Tecnol Veracruz, MA de Quevedo 2779, Xalapa 91897, Veracruz, Mexico.; Ferrer, M (corresponding author), Univ Autonoma Madrid, Fac Med, Dept Fisiol, C Arzobispo Morcillo 4, E-28049 Madrid 28029, Spain.; Ferrer, M (corresponding author), Hosp Univ La Paz IdiPAZ, Inst Invest, Madrid, Spain.; Alexander-Aguilera, A (corresponding author), Univ Veracruzana, Fac Bioanal, Carmen Serdan S-N, Xalapa 91700, Veracruz, Mexico.
EM mercedes.ferrer@uam.es; aalexander_2000@yahoo.com;
   hugo.gg@veracruz.tecnm.mx
RI Alexander-Aguilera, Alfonso/AAH-9203-2019; Villalpando,
   Diva/AAG-6337-2020; Ferrer, Mercedes/E-3556-2018
OI Ferrer Parra, Mercedes/0000-0002-4670-7146
FU CONACyT
FX The authors thank Cesia J. Rojas for her support on biochemical analyses
   and Laura N. Bober (D.V.M.) for performing the surgeries. This study was
   supported by graduate fellowships from CONACyT to M.M.R. and D.M.V.
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NR 59
TC 7
Z9 7
U1 0
U2 8
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1438-7697
EI 1438-9312
J9 EUR J LIPID SCI TECH
JI Eur. J. Lipid Sci. Technol.
PD MAR
PY 2020
VL 122
IS 3
AR 1900098
DI 10.1002/ejlt.201900098
EA JAN 2020
PG 8
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA KT7QO
UT WOS:000510050700001
DA 2025-06-11
ER

PT J
AU Kedenko, L
   Lamina, C
   Kedenko, I
   Kollerits, B
   Kiesslich, T
   Iglseder, B
   Kronenberg, F
   Paulweber, B
AF Kedenko, Lyudmyla
   Lamina, Claudia
   Kedenko, Igor
   Kollerits, Barbara
   Kiesslich, Tobias
   Iglseder, Bernhard
   Kronenberg, Florian
   Paulweber, Bernhard
TI Genetic polymorphisms at SIRT1 and FOXO1 are associated
   with carotid atherosclerosis in the SAPHIR cohort
SO BMC MEDICAL GENETICS
LA English
DT Article
ID INTIMA-MEDIA THICKNESS; METABOLIC SYNDROME; TRANSCRIPTION FACTORS;
   RISK-FACTORS; TASK-FORCE; INSULIN; DYSFUNCTION; WOMEN; PHOSPHORYLATION;
   ENDOTHELIUM
AB Background: SIRT1 and FOXO1 interact with each other in multiple pathways regulating aging, metabolism and resistance to oxidative stress and control different pathways involved in atherosclerotic process. It is not known, if genetic polymorphisms (SNPs) at the SIRT1 and FOXO1 have an influence on carotid atherosclerosis.
   Methods: Intima-media thickness (IMT) was measured on the common and internal carotid arteries. Morphological alterations of the carotid arteries and size of these alterations were included in the B-score grading on a five point scale. Eleven SNPs at SIRT1 and FOXO1 gene loci were genotyped in the SAPHIR cohort (n = 1742). The association of each SNP with common carotid IMT, internal carotid IMT and B-score was analyzed using linear regression models.
   Results: A significant association was found between common carotid IMT and two SNPs at FOXO1 -rs10507486, rs2297627 (beta = -0.00168, p = 0.0007 and beta = -0.00144, p = 0.0008 respectively) and at least a trend for rs12413112 at SIRT1 (beta = 0.00177, p = 0.0157) using an additive model adjusting for age and sex. Additional adjustment for traditional cardiovascular risk factors and markers (BMI, smoking status, hypertension, total cholesterol, HDL-cholesterol, hsCRP) even improved the strength of this association (p = 0.0037 for SIRT1 and p = 0.0002 for both SNPs at FOXO1). Analysis for internal carotis IMT and B-score did not reveal any significant association. One haplotype in FOXO1 showed a moderate effect on common carotid IMT and B-score in comparison to the reference haplotype of this gene. Several SNPs within SIRT1 showed differential effects for men and women with higher effect sizes for women: rs3740051 on all three investigated phenotypes (interaction p-value < 0.0069); rs2236319 on common and internal carotid IMT (interaction p-value < 0.0083), rs10823108, rs2273773 on common carotid IMT and rs1467568 on B-score (interaction p-value = 0.0007). The latter was significant in women only (beta(women) = 0.111, p(women) = 0.00008; beta(men) = -0.009, p(men) = 0.6464).
   Conclusions: This study demonstrated associations of genetic variations at the SIRT1 and FOXO1 loci with carotid atherosclerosis and highlighted the need for further investigation by functional studies.
C1 [Kedenko, Lyudmyla; Kedenko, Igor; Kiesslich, Tobias; Paulweber, Bernhard] Paracelsus Med Univ, Dept Internal Med 1, Salzburger Landeskliniken, A-5020 Salzburg, Austria.
   [Lamina, Claudia; Kollerits, Barbara; Kronenberg, Florian] Paracelsus Med Univ, Inst Physiol & Pathophysiol, A-5020 Salzburg, Austria.
   [Kiesslich, Tobias] Paracelsus Med Univ, Dept Geriatr Med, Christian Doppler Klin, A-5020 Salzburg, Austria.
C3 Paracelsus Private Medical University; Paracelsus Private Medical
   University; Paracelsus Private Medical University
RP Kronenberg, F (corresponding author), Med Univ Innsbruck, Div Genet Epidemiol, Schopfstr 41, A-6020 Innsbruck, Austria.
EM Florian.Kronenberg@i-med.ac.at
RI Lamina, Claudia/F-7608-2010; Kronenberg, Florian/B-1736-2008
OI Kiesslich, Tobias/0000-0001-5403-9478; Kronenberg,
   Florian/0000-0003-2229-1120; Kollerits, Barbara/0000-0002-8889-8315;
   Iglseder, Bernhard/0000-0002-6132-8670; Lamina,
   Claudia/0000-0002-5398-5806
FU Kamilo-Eisner Stiftung; Salzburger Forschungsgesellschaft;
   Forschungsforderungsfond of the Paracelsus Medical University
   [E-09/09/055-PAU]
FX The SAPHIR population was supported by Kamilo-Eisner Stiftung and
   Salzburger Forschungsgesellschaft. Current study was funded by the
   Forschungsforderungsfond of the Paracelsus Medical University (grant Nr.
   E-09/09/055-PAU). The authors would like to thank the field
   investigators of the SAPHIR cohort for their assistance with data
   collection. We appreciate the technical assistance of Fabienne
   Buchsteiner from the University Clinic for Internal Medicine I for
   TaqMan genotyping. Above all, the authors thank the study participants.
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NR 45
TC 53
Z9 55
U1 0
U2 8
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2350
J9 BMC MED GENET
JI BMC Med. Genet.
PD OCT 2
PY 2014
VL 15
AR 112
DI 10.1186/s12881-014-0112-7
PG 11
WC Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Genetics & Heredity
GA AU6LD
UT WOS:000345713700001
PM 25273948
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Long, T
   Cheng, BH
   Zhang, K
AF Long, Ting
   Cheng, Bohuai
   Zhang, Ke
TI Abdominal obesity as assessed by anthropometric measures associates with
   urinary incontinence in females: findings from the National Health and
   Nutrition Examination Survey 2005-2018
SO BMC WOMENS HEALTH
LA English
DT Article
DE Body roundness index; Conicity index; Waist-to-height ratio; Abdominal
   obesity; Urinary incontinence
ID BODY-MASS INDEX; POSTMENOPAUSAL WOMEN; METABOLIC SYNDROME; PREVALENCE;
   MENOPAUSE
AB Background Urinary incontinence (UI) is significantly link to abdominal obesity. This study aimed to assess the association between anthropometric indices of abdominal obesity, including body roundness index (BRI), conicity index (CI), and waist-to-height ratio (WHtR), and UI risk in adult females. Methods We analyzed data from 10, 317 adult females in the National Health and Nutrition Examination Survey (NHANES) database (2005-2018). Weighted multivariable-adjusted regression analysis was conducted to determine the odds ratio (OR) and 95% confidence intervals (CI) for the association between BRI, CI, WHtR, and UI. Stratified analyses revealed the association based on the population type. Receiver operating characteristic curve (ROC) analyses were used to assess the predictive value of UI. Results All indices of abdominal obesity investigated were positively and independently associated with the prevalence and severity of three types of UI. After adjusting for all relevant confounding variables, a significantly positive association between BRI and the prevalence of UI were observed (OR quartile 4 vs. quartile 1: urge UI (UUI): 1.93, 95% CI 1.61-2.30; stress UI (SUI): 2.29, 95% CI 1.94-2.70; mixed UI (MUI): 2.26, 95% CI 1.82-2.82; all P < 0.0001, P for trend < 0.0001, respectively), as well as WHtR and CI, which particularly prominent for female in premenopausal. Moreover, a one-unit increment of BRI was significantly associated with an increased severity index of UUI (beta: 0.06, 95% CI 0.04-0.09, P < 0.0001), SUI (beta: 0.10, 95% CI 0.07-0.13, P < 0.0001) and MUI (beta: 0.07, 95% CI 0.04-0.10, P < 0.0001), which this trend was also observed in each subtype of UI for WHtR and CI. Furthermore, the ROC analysis demonstrated a higher diagnostic efficacy of BRI and WHtR compared with BMI in discriminating UI with an AUC of 0.600 for SUI, 0.617 for UUI, and 0.622 for MUI (all P < 0.05). Conclusions An increased BRI, CI, and WHtR are significantly associated with higher prevalence and severity of UI in females.
C1 [Long, Ting; Zhang, Ke] Hunan Prov Maternal & Child Hlth Care Hosp, Dept Pelv Floor, Changsha 410007, Peoples R China.
   [Cheng, Bohuai] Sun Yat Sen Univ, Affiliated Hosp 6, Dept Otorhinolaryngol Head & Neck Surg, Guangzhou 510655, Peoples R China.
C3 Sun Yat Sen University
RP Zhang, K (corresponding author), Hunan Prov Maternal & Child Hlth Care Hosp, Dept Pelv Floor, Changsha 410007, Peoples R China.
EM 178352865@qq.com
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NR 43
TC 7
Z9 7
U1 3
U2 9
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1472-6874
J9 BMC WOMENS HEALTH
JI BMC Womens Health
PD APR 2
PY 2024
VL 24
IS 1
AR 212
DI 10.1186/s12905-024-03059-2
PG 12
WC Public, Environmental & Occupational Health; Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; Obstetrics & Gynecology
GA MY7R1
UT WOS:001197266500005
PM 38566030
OA gold
DA 2025-06-11
ER

PT J
AU Houston, L
   Probst, YC
   Singh, MC
   Neale, EP
AF Houston, Lauren
   Probst, Yasmine C.
   Singh, Mamatha Chandra
   Neale, Elizabeth P.
TI Tree Nut and Peanut Consumption and Risk of Cardiovascular Disease: A
   Systematic Review and Meta-Analysis of Randomized Controlled Trials
SO ADVANCES IN NUTRITION
LA English
DT Review
DE nuts; peanuts; CVD; cholesterol; lipids; apo; blood pressure;
   meta-analysis
ID SERUM-LIPID PROFILE; IMPROVES ENDOTHELIAL FUNCTION; MODERATE WALNUT
   CONSUMPTION; MONOUNSATURATED FAT DIET; SYSTOLIC BLOOD-PRESSURE;
   HIGH-OLEIC PEANUTS; ENRICHED DIET; ALMOND CONSUMPTION; METABOLIC
   SYNDROME; OXIDATIVE STRESS
AB Cardiovascular disease (CVD) is the leading cause of death globally. Habitual consumption of tree nuts and peanuts is associated with cardioprotective benefits. Food-based dietary guidelines globally recommend nuts as a key component of a healthy diet. This systematic review and meta-analysis were conducted to examine the relationship between tree nut and peanut consumption and risk factors for CVD in randomized controlled trials (RCTs) (PROSPERO: CRD42022309156). MEDLINE, PubMed, CINAHL, and Cochrane Central databases were searched up to 26 September, 2021. All RCT studies that assessed the effects of tree nut or peanut consumption of any dose on CVD risk factors were included. Review Manager software was used to conduct a random effect meta-analysis for CVD outcomes from RCTs. Forest plots were generated for each outcome, between-study heterogeneity was estimated using the I2 test statistic and funnel plots and Egger's test for outcomes with >10 strata. The quality assessment used the Health Canada Quality Appraisal Tool, and the certainty of the evidence was assessed using grading of recommendations assessment, development, and evaluation (GRADE). A total of 153 articles describing 139 studies (81 parallel design and 58 cross-over design) were included in the systematic review, with 129 studies in the meta-analysis. The meta-analysis showed a significant decrease for low-density lipoprotein (LDL) cholesterol, total cholesterol (TC), triglycerides (TG), TC:high-density lipoprotein (HDL) cholesterol, LDL cholesterol:HDL cholesterol, and apolipoprotein B (apoB) following nut consumption. However, the quality of evidence was "low" for only 18 intervention studies. The certainty of the body of evidence for TC:HDL cholesterol, LDL cholesterol:HDL cholesterol, and apoB were "moderate" because of inconsistency, for TG were "low," and for LDL cholesterol and TC were "very low" because of inconsistency and the likelihood of publication bias. The findings of this review provide evidence of a combined effect of tree nuts and peanuts on a range of biomarkers to create an overall CVD risk reduction.
C1 [Houston, Lauren] Univ New South Wales, George Inst Global Hlth, Sydney, NSW, Australia.
   [Houston, Lauren] Univ New South Wales, Fac Med, Sch Med Sci, Sydney, NSW, Australia.
   [Houston, Lauren; Probst, Yasmine C.; Singh, Mamatha Chandra; Neale, Elizabeth P.] Univ Wollongong, Fac Sci, Sch Med Indigenous & Hlth Sci, Wollongong, NSW, Australia.
   [Probst, Yasmine C.; Singh, Mamatha Chandra; Neale, Elizabeth P.] Univ Wollongong, Illawarra Hlth & Med Res Inst, Wollongong, NSW, Australia.
C3 University of New South Wales Sydney; George Institute for Global
   Health; University of New South Wales Sydney; University of Wollongong;
   University of Wollongong; Illawarra Health & Medical Research Institute
RP Houston, L (corresponding author), Univ New South Wales, George Inst Global Hlth, Sydney, NSW, Australia.; Houston, L (corresponding author), Univ New South Wales, Fac Med, Sch Med Sci, Sydney, NSW, Australia.; Houston, L (corresponding author), Univ Wollongong, Fac Sci, Sch Med Indigenous & Hlth Sci, Wollongong, NSW, Australia.
EM lhouston@georgeinstitute.org.au
RI Neale, Elizabeth/H-8514-2019; Singh, Mamatha/AAK-7967-2021; Houston,
   Lauren/J-9728-2016; Probst, Yasmine/A-1342-2008
OI Probst, Yasmine/0000-0002-1971-173X; Houston,
   Lauren/0000-0003-0825-0373; Chandra Singh, Mamatha/0000-0002-5190-9439
FU Australian Nut Industry Council Ltd
FX This research was funded by the Australian Nut Industry Council Ltd,
   which did not provide any input into the design, collection, analysis,
   interpretation of the data, or manuscript writing.
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NR 213
TC 15
Z9 15
U1 1
U2 12
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 2161-8313
EI 2156-5376
J9 ADV NUTR
JI Adv. Nutr.
PD SEP
PY 2023
VL 14
IS 5
BP 1029
EP 1049
DI 10.1016/j.advnut.2023.05.004
EA SEP 2023
PG 21
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA T6RU4
UT WOS:001079245800001
PM 37149262
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Wang, C
   Sun, WY
   Dalbeth, N
   Wang, ZJ
   Wang, XF
   Ji, XP
   Xue, XM
   Han, L
   Cui, LL
   Li, XD
   Liu, Z
   Ji, AC
   He, YW
   Sun, MS
   Li, CG
AF Wang, Can
   Sun, Wenyan
   Dalbeth, Nicola
   Wang, Zhongjun
   Wang, Xuefeng
   Ji, Xiaopeng
   Xue, Xiaomei
   Han, Lin
   Cui, Lingling
   Li, Xinde
   Liu, Zhen
   Ji, Aichang
   He, Yuwei
   Sun, Mingshu
   Li, Changgui
TI Efficacy and safety of tart cherry supplementary citrate mixture on gout
   patients: a prospective, randomized, controlled study
SO ARTHRITIS RESEARCH & THERAPY
LA English
DT Article
DE Gout; Urine alkalization; Sodium bicarbonate; Citrate; Tart cherry
ID LOW URINE PH; OXIDATIVE STRESS; AMERICAN-COLLEGE; CONSUMPTION;
   MANAGEMENT; RISK
AB Background Low urine pH, which may be mediated by metabolic syndrome (MetS), is common in gout. Tar t cherries are shown to improve MetS symptoms and possess anti-inflammatory properties. However, the efficacy of tart cherry supplements on urine pH has yet to be studied.
   Objectives This study aimed to investigate the efficacy and safety of tart cherry supplementary citrate (TaCCi) mixture on urine pH, serum urate (sUA), C-reactive protein (CRP), and gout flares in gout patients initiating urate-lowering therapy (ULT), in comparison to citrate mixture and sodium bicarbonate.
   Methods A prospective, randomized (1:1:1), open-label, parallel-controlled trial was conducted among 282 men with gout and fasting urine pH <= 6, who were initiating ULT with febuxostat (initially 20 mg daily, escalating to 40 mg daily if serum urate >= 360 mu mol/L). Participants were randomized to groups taking either sodium bicarbonate, citrate mixture, or TaCCi mixture. All participants were followed every 4 weeks until week 12. Urine pH and sUA were co-primary outcomes, with various biochemical and clinical secondary endpoints.
   Results Urine pH increased to a similar extent in all three groups. SUA levels declined in all three groups as well, with no significant differences observed between the groups. At week 12, the TaCCi mixture group exhibited a greater reduction in the urine albumin/creatinine ratio (UACR) compared to the other two groups (p < 0.05). Participants taking TaCCi mixture or citrate mixture experienced fewer gout flares than those in the sodium bicarbonate group over the study period (p < 0.05). Additionally, the TaCCi mixture group had a lower CRP level at week 12 relative to the other two groups (p < 0.01). Adverse events were similar across all three groups.
   Conclusion The TaCCi mixture had similar efficacy and safety on urine alkalization and sUA-lowering as the citrate mixture and sodium bicarbonate in patients with gout. However, the TaCCi mixture resulted in greater improvements in UACR and CRP, which suggests that tart cherry supplements may provide additional benefits for renal protection and reduce inflammation in gout, particularly when starting ULT.
C1 [Wang, Can; Wang, Xuefeng; Ji, Xiaopeng; Xue, Xiaomei; Han, Lin; Cui, Lingling; Li, Xinde; Liu, Zhen; Ji, Aichang; He, Yuwei; Li, Changgui] Qingdao Univ, Affiliated Hosp, Shandong Prov Key Lab Metab Dis, Qingdao, Peoples R China.
   [Wang, Can; Wang, Xuefeng; Ji, Xiaopeng; Xue, Xiaomei; Han, Lin; Cui, Lingling; Li, Xinde; Liu, Zhen; Ji, Aichang; He, Yuwei; Li, Changgui] Qingdao Univ, Affiliated Hosp, Qingdao Key Lab Gout, Qingdao, Peoples R China.
   [Wang, Can; Sun, Wenyan; Wang, Xuefeng; Ji, Xiaopeng; Xue, Xiaomei; Han, Lin; Cui, Lingling; Li, Xinde; Liu, Zhen; Ji, Aichang; He, Yuwei; Li, Changgui] Qingdao Univ, Inst Metab Dis, Qingdao, Peoples R China.
   [Wang, Can; Wang, Xuefeng; Ji, Xiaopeng; Xue, Xiaomei; Han, Lin; Cui, Lingling; Li, Xinde; Liu, Zhen; Ji, Aichang; He, Yuwei; Sun, Mingshu; Li, Changgui] Shandong Prov Clin Res Ctr Immune Dis & Gout, Qingdao, Peoples R China.
   [Dalbeth, Nicola] Univ Auckland, Dept Med, Auckland, New Zealand.
   [Wang, Zhongjun] Qingdao Univ, Dept Clin Lab, Affiliated Hosp, Qingdao, Peoples R China.
   [Sun, Mingshu] Qingdao Univ, Affiliated Hosp, Dept Rheumatol, Qingdao, Peoples R China.
C3 Qingdao University; Qingdao University; Qingdao University; University
   of Auckland; Qingdao University; Qingdao University
RP Li, CG (corresponding author), Qingdao Univ, Affiliated Hosp, Shandong Prov Key Lab Metab Dis, Qingdao, Peoples R China.; Li, CG (corresponding author), Qingdao Univ, Affiliated Hosp, Qingdao Key Lab Gout, Qingdao, Peoples R China.; Li, CG (corresponding author), Qingdao Univ, Inst Metab Dis, Qingdao, Peoples R China.; Sun, MS; Li, CG (corresponding author), Shandong Prov Clin Res Ctr Immune Dis & Gout, Qingdao, Peoples R China.; Sun, MS (corresponding author), Qingdao Univ, Affiliated Hosp, Dept Rheumatol, Qingdao, Peoples R China.
EM mingshu.sun@qdu.edu.cn; lichanggui@medmail.com.cn
RI JI, Xiao-Peng/X-2622-2019; Ji, Aichang/IQS-3806-2023; He,
   Yuwei/ABD-4266-2021
OI wang, haoyu/0009-0001-2467-5331; Li, Changgui/0000-0002-4622-3731; Ji,
   Aichang/0000-0002-3726-6844
FU We would like to thank all participants enrolled in this study, and the
   efforts all authors did for this work.
FX We would like to thank all participants enrolled in this study, and the
   efforts all authors did for this work.
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NR 36
TC 7
Z9 7
U1 6
U2 16
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1478-6354
EI 1478-6362
J9 ARTHRITIS RES THER
JI Arthritis Res. Ther.
PD SEP 7
PY 2023
VL 25
IS 1
AR 164
DI 10.1186/s13075-023-03152-1
PG 11
WC Rheumatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Rheumatology
GA R4IN3
UT WOS:001064000100001
PM 37679816
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Armandi, A
   Rosso, C
   Caviglia, GP
   Ribaldone, DG
   Bugianesi, E
AF Armandi, Angelo
   Rosso, Chiara
   Caviglia, Gian Paolo
   Ribaldone, Davide Giuseppe
   Bugianesi, Elisabetta
TI The Impact of Dysmetabolic Sarcopenia Among Insulin Sensitive Tissues: A
   Narrative Review
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Review
DE sarcopenia; insulin resistance; obesity; NAFLD; leptin; microbiota;
   irisin; myostatin
ID HUMAN SKELETAL-MUSCLE; ACID-BINDING PROTEIN; FATTY LIVER-DISEASE; GUT
   MICROBIOTA; SIGNALING PATHWAYS; ADIPOSE-TISSUE; OBESITY; RESISTANCE;
   MICE; INFLAMMATION
AB Sarcopenia is a common muscular affection among elderly individuals. More recently, it has been recognized as the skeletal muscle (SM) expression of the metabolic syndrome. The prevalence of sarcopenia is increasing along with visceral obesity, to which it is tightly associated. Nonetheless, it is a still underreported entity by clinicians, despite the worsening in disease burden and reduced patient quality of life. Recognition of sarcopenia is clinically challenging, and variability in study populations and diagnostic methods across the clinical studies makes it hard to reach a strong evidence. Impaired insulin activity in SM is responsible for the altered molecular pathways and clinical manifestations of sarcopenia, which is morphologically expressed by myosteatosis. Lipotoxicity, oxidative stress and adipose tissue-derived inflammation lead to both alterations in glucose disposal and protein synthesis in SM, with raising insulin resistance (IR) and SM atrophy. In particular, hyperleptinemia and leptin resistance interfere directly with SM activity, but also with the release of Growth Hormone from the hypohysis, leading to a lack in its anabolic effect on SM. Moreover, sarcopenia is independently associated to liver fibrosis in Non-Alcoholic Fatty Liver Disease (NAFLD), which in turn worsens SM functionality through the secretion of proinflammatory heptokines. The cross-talk between the liver and SM in the IR setting is of crucial relevance, given the high prevalence of NAFLD and the reciprocal impact of insulin-sensitive tissues on the overall disease burden. Along with the efforts of non-invasive diagnostic approaches, irisin and myostatin are two myokines currently evaluated as potential biomarkers for diagnosis and prognostication. Decreased irisin levels seem to be potentially associated to sarcopenia, whereas increased myostatin has shown to negatively impact on sarcopenia in pre-clinical studies. Gene variants in irisin have been explored with regard to the impact on the liver disease phenotype, with conflicting results. The gut-muscle axis has gain relevance with the evidence that insulin resistance-derived gut dysbiosis is responsible for increased endotoxemia and reduction in short-chain free fatty acids, directly affecting and predisposing to sarcopenia. Based on the current evidence, more efforts are needed to increase awareness and improve the management of sarcopenic patients.
C1 [Armandi, Angelo; Rosso, Chiara; Caviglia, Gian Paolo; Ribaldone, Davide Giuseppe; Bugianesi, Elisabetta] Univ Turin, Dept Med Sci, Div Gastroenterol & Hepatol, AO Citta Salute & Sci Torino, Turin, Italy.
C3 University of Turin; A.O.U. Citta della Salute e della Scienza di Torino
RP Bugianesi, E (corresponding author), Univ Turin, Dept Med Sci, Div Gastroenterol & Hepatol, AO Citta Salute & Sci Torino, Turin, Italy.
EM elisabetta.bugianesi@unito.it
RI Rosso, Chiara/AAY-4336-2021; Bugianesi, Elisabetta/K-8008-2016;
   Ribaldone, Davide/H-3478-2019; Caviglia, Gian/H-6076-2012; Armandi,
   Angelo/AAU-6395-2020
OI Ribaldone, Davide Giuseppe/0000-0002-9421-3087; Caviglia, Gian
   Paolo/0000-0002-0529-9481
FU Italian Ministry for Education, University and Research (Ministero
   dell'Istruzione, dell'Universita e della Ricerca - MIUR) under the
   programme "Dipartimenti di Eccellenza 2018 - 2022" [D15D18000410001]
FX Italian Ministry for Education, University and Research (Ministero
   dell'Istruzione, dell'Universita e della Ricerca - MIUR) under the
   programme "Dipartimenti di Eccellenza 2018 - 2022" Project code
   D15D18000410001.
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NR 104
TC 29
Z9 30
U1 2
U2 15
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD NOV 10
PY 2021
VL 12
AR 716533
DI 10.3389/fendo.2021.716533
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA XT7OV
UT WOS:000733773100001
PM 34858322
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Dosa, MD
   Hangan, LT
   Crauciuc, E
   Gales, C
   Nechifor, M
AF Dosa, Monica Daniela
   Hangan, Laurentiu-Tony
   Crauciuc, Eduard
   Gales, Cristina
   Nechifor, Mihai
TI Influence of Therapy with Metformin on the Concentration of Certain
   Divalent Cations in Patients with Non-insulin-Dependent Diabetes
   Mellitus
SO BIOLOGICAL TRACE ELEMENT RESEARCH
LA English
DT Article
DE NIDDM; Magnesium; Zinc; Copper; Metformin; Plasma glucose
ID LOW DIETARY MAGNESIUM; METABOLIC SYNDROME; OXIDATIVE STRESS; ZINC;
   RESISTANCE; COPPER; SUPPLEMENTATION; DEFICIENCY; MANGANESE; CHROMIUM
AB Research was performed on a group of 30 patients with non-insulin-dependent diabetes mellitus (NIDDM), who never received antidiabetic medication before, and on a group of 17 healthy adults. The patients were administered treatment with metformin, 1,000 mg/day. Plasmatic and urinary concentration of magnesium have been measured, copper and zinc along with the concentrations of glucose, HDL, LDL, cholesterol, tryglicerides, HbA1c, and total erythrocyte magnesium, in advance and after 3 months of treatment. Data showed significant differences in the NIDDM group vs the control group: for plasma magnesium-1.95 +/- 0.19 vs 2.20 +/- 0.18 mg/dl, p < 0.001; urine magnesium-237.28 +/- 34.51 vs 126.25 +/- 38.22 mg/24 h, p < 0.001; erythrocyte magnesium-5.09 +/- 0.63 vs 6.38 +/- 0.75 mg/dl, p < 0.001; plasma zinc-67.56 +/- 6.21 vs 98.41 +/- 20.47 mu g/dl, p < 0.001; urine zinc-1,347.54 +/- 158.24 vs 851.65 +/- 209.75 mu g/24 h, p < 0.001; plasma copper-111.91 +/- 20.98 vs 96.33 +/- 8.56 mu g/dl, p < 0.001; and urine copper-51.70 +/- 23.79 vs 36.00 +/- 11.70 mu g/24 h, p < 0.05. Treatment with metformin for 3 months modified significant erythrocyte magnesium-5.75 +/- 0.61 vs 5.09 +/- 0.63 mg/dl, p < 0.001 and urine magnesium-198.27 +/- 27.07 vs 237.28 +/- 34.51 mg/24 h, p < 0.001, whereas it did not modify significant the plasmatic and urinary concentration of the other cations. The erythrocyte magnesium concentration was inversely correlated with HbA1c (r = -0.438, p = 0.015). The plasma level of copper was positively correlated with HbA1c (r = 0.517, p < 0.003), tryglicerides (r = 0.534, p < 0.003), and cholesterol (r = 0.440, p < 0.05), and the plasma level of zinc was inversely correlated with glycemia (r = -0.399, p = 0.029). Our data show a significant action of metformin therapy, by increasing the total intraerythrocyte magnesium concentration and decreasing the urinary magnesium elimination, positively correlated with the decrease of glycemia and HbA1c in NIDDM patients.
C1 [Dosa, Monica Daniela] Ovidius Univ Constanta, Dept Pharmacol, Sch Med, Constanta 900470, Romania.
   [Dosa, Monica Daniela] Gr T Popa Univ Med & Pharm Iasi, Iasi, Romania.
   [Crauciuc, Eduard] UMF GR T Popa Univ Med & Pharm Iasi, Obstet Gynecol Dept, Iasi, Romania.
   [Gales, Cristina] GR T Popa Univ Med & Pharm Iasi, Hystol Dept, Iasi, Romania.
   [Nechifor, Mihai] UMF GR T Popa Univ Med & Pharm Iasi, Dept Pharmacol, Iasi, Romania.
C3 Ovidius University; Grigore T Popa University of Medicine & Pharmacy;
   Grigore T Popa University of Medicine & Pharmacy; Grigore T Popa
   University of Medicine & Pharmacy; Grigore T Popa University of Medicine
   & Pharmacy
RP Dosa, MD (corresponding author), Ovidius Univ Constanta, Dept Pharmacol, Sch Med, Univ Alley 2, Constanta 900470, Romania.
EM monicadanielad@yahoo.com
RI nechifor, mihai/GQO-9715-2022; Hangan, Laurentiu/HSG-2618-2023; Dosa,
   Monica/S-4656-2019; gales, cristina/C-9564-2015
OI Hangan, Laurentiu Tony/0009-0004-0902-337X
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NR 41
TC 19
Z9 19
U1 0
U2 13
PU HUMANA PRESS INC
PI TOTOWA
PA 999 RIVERVIEW DRIVE SUITE 208, TOTOWA, NJ 07512 USA
SN 0163-4984
EI 1559-0720
J9 BIOL TRACE ELEM RES
JI Biol. Trace Elem. Res.
PD JUL
PY 2011
VL 142
IS 1
BP 36
EP 46
DI 10.1007/s12011-010-8751-9
PG 11
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 775RS
UT WOS:000291481600005
PM 20567934
DA 2025-06-11
ER

PT J
AU Jackson, G
   Boon, N
   Eardley, I
   Kirby, M
   Dean, J
   Hackett, G
   Montorsi, P
   Montorsi, F
   Vlachopoulos, C
   Kloner, R
   Sharlip, I
   Miner, M
AF Jackson, G.
   Boon, N.
   Eardley, I.
   Kirby, M.
   Dean, J.
   Hackett, G.
   Montorsi, P.
   Montorsi, F.
   Vlachopoulos, C.
   Kloner, R.
   Sharlip, I.
   Miner, M.
TI Erectile dysfunction and coronary artery disease prediction:
   evidence-based guidance and consensus
SO INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
LA English
DT Article
ID RANDOMIZED CONTROLLED-TRIAL; HIGH-RISK PATIENTS; ACE-INTOLERANT
   SUBJECTS; ISCHEMIC-HEART-DISEASE; CHRONIC STABLE ANGINA; LIFE-STYLE
   CHANGES; CARDIOVASCULAR-DISEASE; SILDENAFIL-CITRATE; DOUBLE-BLIND;
   METABOLIC SYNDROME
AB P>A significant proportion of men with erectile dysfunction (ED) exhibit early signs of coronary artery disease (CAD), and this group may develop more severe CAD than men without ED (Level 1, Grade A).
   The time interval among the onset of ED symptoms and the occurrence of CAD symptoms and cardiovascular events is estimated at 2-3 years and 3-5 years respectively; this interval allows for risk factor reduction (Level 2, Grade B).
   ED is associated with increased all-cause mortality primarily due to increased cardiovascular mortality (Level 1, Grade A).
   All men with ED should undergo a thorough medical assessment, including testosterone, fasting lipids, fasting glucose and blood pressure measurement. Following assessment, patients should be stratified according to the risk of future cardiovascular events. Those at high risk of cardiovascular disease should be evaluated by stress testing with selective use of computed tomography (CT) or coronary angiography (Level 1, Grade A).
   Improvement in cardiovascular risk factors such as weight loss and increased physical activity has been reported to improve erectile function (Level 1, Grade A).
   In men with ED, hypertension, diabetes and hyperlipidaemia should be treated aggressively, bearing in mind the potential side effects (Level 1, Grade A).
   Management of ED is secondary to stabilising cardiovascular function, and controlling cardiovascular symptoms and exercise tolerance should be established prior to initiation of ED therapy (Level 1, Grade A).
   Clinical evidence supports the use of phosphodiesterase 5 (PDE5) inhibitors as first-line therapy in men with CAD and comorbid ED and those with diabetes and ED (Level 1, Grade A).
   Total testosterone and selectively free testosterone levels should be measured in all men with ED in accordance with contemporary guidelines and particularly in those who fail to respond to PDE5 inhibitors or have a chronic illness associated with low testosterone (Level 1, Grade A).
   Testosterone replacement therapy may lead to symptomatic improvement (improved wellbeing) and enhance the effectiveness of PDE5 inhibitors (Level 1, Grade A).
   Review of cardiovascular status and response to ED therapy should be performed at regular intervals (Level 1, Grade A).
C1 [Jackson, G.] London Bridge Hosp, London SE1 2PR, England.
   [Eardley, I.] St James Hosp, Leeds, W Yorkshire, England.
   [Dean, J.] Plymouth Nuffield Hosp, Plymouth, Devon, England.
   [Montorsi, P.] Univ Milan, Inst Cardiol, Milan, Italy.
   [Montorsi, F.] Univ Vita Salute Osped S Raffaele, Dept Urol & Sexual Dis, Milan, Italy.
   [Vlachopoulos, C.] Hippokrateion Hosp, Athens Med Sch, Dept Cardiol 1, Cardiovasc Dis & Sexual Hlth Unit, Athens, Greece.
   [Kloner, R.] Univ So Calif, Good Samaritan Hosp, Inst Heart, Los Angeles, CA USA.
   [Sharlip, I.] Univ Calif San Francisco, San Francisco, CA 94143 USA.
   [Miner, M.] Brown Univ, Miriam Hosp, Warren Alpert Sch Med, Mens Hlth Ctr, Providence, RI USA.
   [Kloner, R.] Univ So Calif, Keck Sch Med, Los Angeles, CA 90033 USA.
   [Hackett, G.] Good Hope Hosp Sutton Coldfield, Birmingham, W Midlands, England.
   [Kirby, M.] Univ Hertfordshire, Fac Hlth & Human Sci, Hertford, England.
   [Boon, N.] Univ Edinburgh, Ctr Cardiovasc Sci, Edinburgh, Midlothian, Scotland.
C3 Saint James's University Hospital; University of Milan; National &
   Kapodistrian University of Athens; Hippokration General Hospital;
   University of Southern California; University of California System;
   University of California San Francisco; Lifespan Health Rhode Island;
   Miriam Hospital; Brown University; University of Southern California;
   Heart of England NHS Foundation Trust; Good Hope Hospital; University of
   Hertfordshire; University of Edinburgh
RP Jackson, G (corresponding author), London Bridge Hosp, 27 Tooley St, London SE1 2PR, England.
EM gjcardiol@talk21.com
RI Montorsi, Piero/ABG-9579-2020; Montorsi, Francesco/AAN-2473-2020;
   Kloner, Robert/B-2971-2012
FU Lilly [1104691]
FX The development of this manuscript was supported by an educational grant
   from Lilly donated to the Sexual Advice Association (Charity
   Registration Number: 1104691). The content of this study has not been
   influenced in any way by Lilly.
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NR 105
TC 161
Z9 176
U1 0
U2 9
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1368-5031
EI 1742-1241
J9 INT J CLIN PRACT
JI Int. J. Clin. Pract.
PD JUN
PY 2010
VL 64
IS 7
BP 848
EP 857
DI 10.1111/j.1742-1241.2010.02410.x
PG 10
WC Medicine, General & Internal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Pharmacology & Pharmacy
GA 597UX
UT WOS:000277788700006
PM 20584218
OA gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Yamashima, T
AF Yamashima, Tetsumori
TI 4-Hydroxynonenal from Mitochondrial and Dietary Sources Causes Lysosomal
   Cell Death for Lifestyle-Related Diseases
SO NUTRIENTS
LA English
DT Review
DE calpain-cathepsin hypothesis; cardiolipin; GPR40; Hsp70.1; lysosomal
   rupture; POMC neuron; ROS
ID FATTY-ACID RECEPTOR; HOMOCYSTEINE S-METHYLTRANSFERASE; DENSITY
   LIPOPROTEIN SECRETION; ONSET ALZHEIMERS-DISEASE; ENZYME GENE-EXPRESSION;
   PANCREATIC BETA-CELLS; LIPID-PEROXIDATION; OXIDATIVE STRESS;
   INSULIN-RESISTANCE; ALDEHYDE DEHYDROGENASE
AB Excessive consumption of vegetable oils such as soybean and canolla oils containing omega-6 polyunsaturated fatty acids is considered one of the most important epidemiological factors leading to the progression of lifestyle-related diseases. However, the underlying mechanism of vegetable-oil-induced organ damage is incompletely elucidated. Since proopiomelanocortin (POMC) neurons in the hypothalamus are related to the control of appetite and energy expenditure, their cell degeneration/death is crucial for the occurrence of obesity. In patients with metabolic syndrome, saturated fatty acids, especially palmitate, are used as an energy source. Since abundant reactive oxygen species are produced during beta-oxidation of the palmitate in mitochondria, an increased amount of 4-hydroxy-2-nonenal (4-HNE) is endogenously generated from linoleic acids constituting cardiolipin of the inner membranes. Further, due to the daily intake of deep-fried foods and/or high-fat diets cooked using vegetable oils, exogenous 4-HNE being generated via lipid peroxidation during heating is incorporated into the blood. By binding with atheromatous and/or senile plaques, 4-HNE inactivates proteins via forming hybrid covalent chemical addition compounds and causes cellular dysfunction and tissue damage by the specific oxidation carbonylation. 4-HNE overstimulates G-protein-coupled receptors to induce abnormal Ca2+ mobilization and mu -calpain activation. This endogenous and exogenous 4-HNE synergically causes POMC neuronal degeneration/death and obesity. Then, the resultant metabolic disorder facilitates degeneration/death of hippocampal neurons, pancreatic beta-cells, and hepatocytes. Hsp70.1 is a molecular chaperone which is crucial for both protein quality control and the stabilization of lysosomal limiting membranes. Focusing on the monkey hippocampus after ischemia, previously we formulated the 'calpain-cathepsin hypothesis', i.e., that calpain-mediated cleavage of carbonylated Hsp70.1 is a trigger of programmed neuronal death. This review aims to report that in diverse organs, lysosomal cell degeneration/death occurs via the calpain-cathepsin cascade after the consecutive injections of synthetic 4-HNE in monkeys. Presumably, 4-HNE is a root substance of lysosomal cell death for lifestyle-related diseases.
C1 [Yamashima, Tetsumori] Kanazawa Univ, Grad Sch Med Sci, Dept Psychiat & Behav Sci, Takara Machi 13-1, Kanazawa 9208040, Japan.
C3 Kanazawa University
RP Yamashima, T (corresponding author), Kanazawa Univ, Grad Sch Med Sci, Dept Psychiat & Behav Sci, Takara Machi 13-1, Kanazawa 9208040, Japan.
EM yamashima215@gmail.com
FU Japanese Ministry of Education, Culture, Sports, Science and Technology;
    [19H04029]
FX This work was supported by a grant from Kiban-Kenkyu (B) (19H04029) from
   the Japanese Ministry of Education, Culture, Sports, Science and
   Technology.
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NR 169
TC 2
Z9 2
U1 1
U2 1
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD DEC
PY 2024
VL 16
IS 23
AR 4171
DI 10.3390/nu16234171
PG 26
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA P2U0I
UT WOS:001376512100001
PM 39683565
OA gold
DA 2025-06-11
ER

PT J
AU Li, YX
   Zhou, YY
   Wang, LY
   Lin, XQ
   Mao, MH
   Yin, SQ
   Zhu, L
   Jiao, YF
   Yu, WF
   Gao, P
   Yang, LQ
AF Li, Yixuan
   Zhou, Yanyu
   Wang, Liya
   Lin, Xiaoqi
   Mao, Menghan
   Yin, Suqing
   Zhu, Ling
   Jiao, Yingfu
   Yu, Weifeng
   Gao, Po
   Yang, Liqun
TI Emerging trends and hotspots in the links between the gut microbiota and
   MAFLD from 2002 to 2021: A bibliometric analysis
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Article
DE gut microbiota (GM); MAFLD; bibliometric analysis (BA); hotspots;
   CiteSpace
ID NONALCOHOLIC FATTY LIVER; DISEASE; PROGRESSION; DYSBIOSIS;
   STEATOHEPATITIS; METABOLOME; FIBROSIS; ACID
AB BackgroundThe prevalence of metabolic associated fatty liver disease (MAFLD) presented a booming growth over recent years in the whole world. MAFLD was associated with a higher risk of end-stage liver disease, hepatocellular carcinoma and liver transplantation. Accumulating evidence indicated that gut microbiota and MAFLD were interrelated and interacted with each other. However, to the knowledge of the authors, no bibliometric quantitative analysis has been carried out to evaluate the links between the gut microbiota and MAFLD. This study aimed to use bibliometric analysis to evaluate current publication trends and hotspots in the links between the gut microbiota and MAFLD, in order to advance research in this field. MethodsThe articles regarding the links between gut microbiota and MAFLD from 2002 to 2021 were identified from the Science Citation Index-Expanded of Web of Science Core Collection. CiteSpace software, Vosviewer, the R package "bibliometrix" and the Online Analysis Platform of Literature Metrology were used to analyze current publication trends and hotspots in this field. ResultsA total of 707 articles were retrieved regarding the links between gut microbiota and MAFLD from 2002 to 2021. The USA occupied the leading role until 2015 and the dominance of China started in 2016. The USA was the most frequently involved country in international cooperation. Shanghai Jiao Tong University was the most productive institution. Ina Bergheim was the most productive author, publishing 14 articles. The co-citation keywords cluster label displayed ten main clusters: probiotics, bile acid, immune function, adolescents, nutritional genomics, high fat diet, systems biology, lipopolysaccharides, phosphatidylcholine, and oxidative stress. Keyword bursts analysis indicated that diet induced obesity, metabolic syndrome, ppar alpha, and lactobacillus were the research hotspots with high strength. ConclusionThe number of publications covering the links of gut microbiota and MAFLD increased dramatically in the past decade and especially became exponential growth in the last 3 years. Probiotics and bile acid will be the research direction of great importance in the etiology and novel treatment for MAFLD. This study provided systematic information and instructive assistance for future research work, that helped to discover the mechanisms and new treatments of MAFLD.
C1 [Li, Yixuan; Zhou, Yanyu; Lin, Xiaoqi; Mao, Menghan; Yin, Suqing; Zhu, Ling; Jiao, Yingfu; Yu, Weifeng; Gao, Po; Yang, Liqun] Shanghai Jiao Tong Univ, Sch Med, Renji Hosp, Dept Anesthesiol, Shanghai, Peoples R China.
   [Wang, Liya] Shanghai Jiao Tong Univ, Sch Med, Int Peace Matern & Child Hlth Hosp, Dept Gynecol Oncol,Shanghai Key Lab Embryo Origina, Shanghai, Peoples R China.
C3 Shanghai Jiao Tong University; Shanghai Jiao Tong University
RP Gao, P; Yang, LQ (corresponding author), Shanghai Jiao Tong Univ, Sch Med, Renji Hosp, Dept Anesthesiol, Shanghai, Peoples R China.
EM gaopo0908@163.com; lqyang72721@126.com
RI Jiao, Yingfu/HNS-2307-2023; Zhou, Yanyu/GXF-4357-2022; Yang,
   Liqun/M-3626-2019; Lin, Xiaoqi/KFS-5750-2024; Gao, Po/JXN-1788-2024; li,
   yixuan/KIL-2742-2024
FU National Natural Science Foundation of China [82270916]; Shanghai
   Hospital Development Center [SHDC2020CR2055B]; Science and Technology
   Commission of Shanghai Municipality [20410760500]; National key research
   and development program [2018YFC201803]; Key Specialty Construction
   Project of Pudong Health and Family Planning Commission of Shanghai
   [PWZXQ2017-06]; Shanghai Municipal Key Clinical Specialty
   [shslczdzk03601]; Innovation Program of Shanghai Municipal Education
   Commission [2019-01-07-00-01-E00074]; Shanghai Engineering Research
   Center of Peri-operative Organ Support and Function Preservation
   [20DZ2254200]
FX This study was funded by the National Natural Science Foundation of
   China (No. 82270916), Shanghai Hospital Development Center (No.
   SHDC2020CR2055B), Science and Technology Commission of Shanghai
   Municipality (No. 20410760500), National key research and development
   program (No. 2018YFC201803), Key Specialty Construction Project of
   Pudong Health and Family Planning Commission of Shanghai (No.
   PWZXQ2017-06), Shanghai Municipal Key Clinical Specialty (No.
   shslczdzk03601), Innovation Program of Shanghai Municipal Education
   Commission (No. 2019-01-07-00-01-E00074) and Shanghai Engineering
   Research Center of Peri-operative Organ Support and Function
   Preservation (20DZ2254200).
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NR 48
TC 20
Z9 21
U1 4
U2 44
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD OCT 13
PY 2022
VL 13
AR 990953
DI 10.3389/fendo.2022.990953
PG 17
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 5X5QI
UT WOS:000878653800001
PM 36329894
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Xu, MX
   Qin, YT
   Ge, CX
   Gu, TT
   Lou, DS
   Li, Q
   Hu, LF
   Li, YY
   Yang, WW
   Tan, J
AF Xu, Min-Xuan
   Qin, Yu-Ting
   Ge, Chen-Xu
   Gu, Ting-Ting
   Lou, De-Shuai
   Li, Qiang
   Hu, Lin-Feng
   Li, Yuan-Yuan
   Yang, Wei-Wei
   Tan, Jun
TI Activated iRhom2 drives prolonged PM2.5 exposure-triggered
   renal injury in Nrf2-defective mice
SO NANOTOXICOLOGY
LA English
DT Article
DE Particulate matter 2.5 (PM2.5); iRhom2; TNF-alpha; kidney injury; Nrf2
ID LONG-TERM EXPOSURE; AIR-POLLUTION; PARTICULATE MATTER; ATTRIBUTABLE
   RISK; AMBIENT PM2.5; TNF-ALPHA; INFLAMMATION; DISEASE; MACROPHAGES;
   MECHANISMS
AB Research suggests that particulate matter (PM2.5) is a predisposing factor for metabolic syndrome-related systemic inflammation and oxidative stress injury. TNF-alpha as a major pro-inflammatory cytokine was confirmed to participate in various diseases. Inactive rhomboid protein 2 (iRhom2) was recently determined as a necessary regulator for shedding of TNF-alpha in immune cells. Importantly, kidney-resident macrophages are critical to inflammation-associated chronic renal injury. Podocyte injury can be induced by stimulants and give rise to nephritis, but how iRhom2 contributes to PM2.5-induced renal injury is unclear. Thus, we studied whether PM2.5 causes renal injury and characterized iRhom2 with respect to TNF-alpha release in mice macrophages and renal tissues in long-term PM2.5-exposed mouse models. After long-term PM2.5 exposures, renal injury was confirmed via inflammatory cytokine, chemokine expression, and reduced antioxidant activity. Patients with kidney-related diseases had increased TNF-alpha, which may contribute to renal injury. We observed up-regulation of serum creatinine, serum urea nitrogen, kidney injury molecule 1, uric acid, TNF-alpha, MDA, H2O2, and O-2(-) in PM2.5-treated mice, which was greater than that found in Nrf2(-/-) mice. Meanwhile, increases in metabolic disorder-associated indicators were involved in PM2.5-induced nephritis. In vitro, kidney-resident macrophages were observed to be critical to renal inflammatory infiltration and function loss via regulation of iRhom2/TACE/TNF-alpha signaling, and suppression of Nrf2-associated anti-oxidant response. PM2.5 exposure led to renal injury partly by inflammation-mediated podocyte injury. Reduced SOD1, SOD2, Nrf2 activation, and increased XO, NF-kappa B activity, TACE, iNOS, IL-1 beta, TNF-alpha, IL-6, MIP-1 alpha, Emr-1, MCP-1, and Cxcr4, were also noted. Long-term PM2.5 exposure causes chronic renal injury by up-regulation of iRhom2/TACE/TNF-alpha axis in kidney-resident macrophages. Overexpression of TNF-alpha derived from macrophages causes podocyte injury and kidney function loss. Thus, PM2.5 toxicities are related to exposure duration and iRhom2 may be a potential therapeutic renal target.
C1 [Xu, Min-Xuan; Ge, Chen-Xu; Lou, De-Shuai; Li, Qiang; Hu, Lin-Feng; Tan, Jun] Chongqing Univ Educ, Sch Biol & Chem Engn, Chongqing Key Lab Med Resources Three Gorges Rese, Chongqing 400067, Peoples R China.
   [Qin, Yu-Ting] Ocean Univ China, Sch Med & Pharm, Qingdao, Peoples R China.
   [Gu, Ting-Ting] Nanjing Univ, Coll Engn & Appl Sci, Nanjing, Jiangsu, Peoples R China.
   [Li, Yuan-Yuan] Chongqing Univ Educ, Sch Biol & Chem Engn, Chongqing, Peoples R China.
   [Yang, Wei-Wei] Nanjing Med Univ, Huaian Peoples Hosp 1, Dept Nephrol, Nanjing, Jiangsu, Peoples R China.
   [Xu, Min-Xuan; Ge, Chen-Xu; Lou, De-Shuai; Li, Qiang; Hu, Lin-Feng; Tan, Jun] Chongqing Univ Educ, Res Ctr Brain Intellectual Promot & Dev Children, Chongqing, Peoples R China.
C3 Chongqing University of Education; Ocean University of China; Nanjing
   University; Chongqing University of Education; Nanjing Medical
   University; Chongqing University of Education
RP Xu, MX; Tan, J (corresponding author), Chongqing Univ Educ, Sch Biol & Chem Engn, Chongqing Key Lab Med Resources Three Gorges Rese, Chongqing 400067, Peoples R China.
EM minxuanxu@foxmail.com; tanjunmail@126.com
RI hu, linfeng/C-6491-2014
OI Xu, Minxuan/0000-0002-0742-4717
FU National Natural Science Foundation of China (NSFC) [81703527];
   Chongqing Research Program of Basic Research and Frontier Technology
   [cstc2017jcyjAXE6, cstc2018jcyjA3686, cstc2018jcyjA1472,
   cstc2018jcyjA3533]; School-level Research Program of Chongqing
   University of Education [KY201710B, 17GZKP01]; Advanced Programs of
   Post-doctor of Chongqing [2017LY39]; Fudamental Research Funds for the
   Central Universities [021314380120]
FX This work was supported by National Natural Science Foundation of China
   (NSFC Grant number: 81703527); Chongqing Research Program of Basic
   Research and Frontier Technology (Grant number: cstc2017jcyjAXE6,
   cstc2018jcyjA3686, cstc2018jcyjA1472 and cstc2018jcyjA3533);
   School-level Research Program of Chongqing University of Education
   (Grant number: KY201710B and 17GZKP01); Advanced Programs of Post-doctor
   of Chongqing (Grant number: 2017LY39) and Fudamental Research Funds for
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NR 53
TC 31
Z9 33
U1 1
U2 51
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1743-5390
EI 1743-5404
J9 NANOTOXICOLOGY
JI Nanotoxicology
PD OCT 21
PY 2018
VL 12
IS 9
BP 1045
EP 1067
DI 10.1080/17435390.2018.1513093
PG 23
WC Nanoscience & Nanotechnology; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics; Toxicology
GA HL7BK
UT WOS:000458891700007
PM 30257117
DA 2025-06-11
ER

PT J
AU Miao, MQ
   Yang, YY
   Dai, HL
AF Miao, Meiqi
   Yang, Yuanyuan
   Dai, Hailong
TI Current research status and future prospects of NLRP3 inflammasome in
   cardiovascular diseases: a bibliometric and visualization analysis
SO FRONTIERS IN CARDIOVASCULAR MEDICINE
LA English
DT Review
DE cardiovascular diseases (CVDs); bibliometrics; CiteSpace; NLPR3
   inflammasome; visualization analysis
ID C-REACTIVE PROTEIN; ATHEROSCLEROSIS; INTERLEUKIN-6; RISK; CHOLESTEROL;
   THERAPY
AB Background Cardiovascular disease (CVD) is a leading cause of global mortality, with atherosclerosis (AS) contributing to its pathological basis. Inflammation plays a critical role in the pathophysiological process of AS, and the NOD-like receptor protein 3 (NLRP3) inflammasome has been extensively studied in this context. This study aimed to analyze the research status of the NLRP3 inflammasome in cardiovascular disease and provide research directions for further exploration in this field.Methods Using the "Bibliometrix" and "CiteSpace" software, a total of 516 articles were retrieved from the Web of Science (WoS) database published between 2012 and 2023. The search query used the keywords "["CVD" OR "cardiovascular disease"] AND ["NLRP3 inflammasome "OR "NLRP3"]". Visual analysis was performed on authors, countries, institutions, journal sources, keywords, references, and future trends.Results A total of 516 English articles were retrieved, showing an overall upward trend in annual publication volume with slight fluctuations. China, the United States, and Europe were the countries and regions with the highest number of published articles. Among them, China had the highest article count (170), while the United States had the highest citation count (18,664), centrality score (0.43), and h-index (90), indicating its influential role in this research area. These countries also possessed elite institutions, professional researchers, and high-impact journals, making them leading contributors in this field. The main pathogenic mechanisms of the NLRP3 inflammasome in CVD were identified as "oxidative stress", "pyroptosis", and "inflammation". The most frequently studied signaling pathways included "NF-kappa B", "IL-1", and "C-reactive protein". The most studied disease types were coronary heart disease, atherosclerosis, metabolic syndrome, and myocardial infarction. Additionally, research on the correlation between cholesterol markers and inflammatory indicators associated with NLRP3 inflammasome in CVD risk assessment has gained significant momentum, with the main mechanism being NLRP3/IL-6/hs-CRP and cholesterol lipoproteins emerging as a major keyword in this context.Conclusion This study provides valuable insights into the research hotspots and emerging trends of the NLRP3 inflammasome in cardiovascular disease. The findings offer guidance for researchers and scholars in this field and facilitate the exploration of new research directions.
C1 [Miao, Meiqi] Heilongjiang Univ Tradit Chinese Med, Affiliated Hosp 1, Dept Cardiol, Harbin, Peoples R China.
   [Yang, Yuanyuan] Beijing Univ Tradit Chinese Med, Dongzhimen Hosp, Dept Acupuncture, Beijing, Peoples R China.
   [Dai, Hailong] Kunming Med Univ, Yanan Affiliated Hosp, Dept Cardiol, Kunming, Peoples R China.
   [Miao, Meiqi] Kunshan Hosp Chinese Med, Dept Cardiovasc Med, Kunshan, Peoples R China.
C3 Heilongjiang University of Chinese Medicine; Beijing University of
   Chinese Medicine; Kunming Medical University
RP Yang, YY (corresponding author), Beijing Univ Tradit Chinese Med, Dongzhimen Hosp, Dept Acupuncture, Beijing, Peoples R China.; Dai, HL (corresponding author), Kunming Med Univ, Yanan Affiliated Hosp, Dept Cardiol, Kunming, Peoples R China.
EM yuanyuan5250@163.com; 46944404@qq.com
RI Miao, Meiqi/HNB-8408-2023
OI Miao, Meiqi/0000-0003-3675-5248
FU National Natural Science Foundation of China [82060018, 81700438];
   Yunnan Fundamental Research Projects [202301AY070001-300,
   202101AS070043, 202102AA310003-7]
FX The author(s) declare financial support was received for the research,
   authorship, and/or publication of this article. This work was supported
   by the National Natural Science Foundation of China (82060018 and
   81700438), Yunnan Fundamental Research Projects
   (202301AY070001-300,202101AS070043 and 202102AA310003-7).
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NR 45
TC 0
Z9 0
U1 5
U2 15
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2297-055X
J9 FRONT CARDIOVASC MED
JI Front. Cardiovasc. Med.
PD JUL 3
PY 2024
VL 11
AR 1407721
DI 10.3389/fcvm.2024.1407721
PG 17
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA ZW1Q4
UT WOS:001278235800001
PM 39022620
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Jain, SK
   Margret, JJ
   Abrams, SA
   Levine, SN
   Bhusal, K
AF Jain, Sushil K.
   Margret, Jeffrey Justin
   Abrams, Steven A.
   Levine, Steven N.
   Bhusal, Kamal
TI The Impact of Vitamin D and L-Cysteine Co-Supplementation on
   Upregulating Glutathione and Vitamin D-Metabolizing Genes and in the
   Treatment of Circulating 25-Hydroxy Vitamin D Deficiency
SO NUTRIENTS
LA English
DT Review
DE 25(OH)VD deficiency; African American; androgenic index; GSH; H2S;
   inflammation; L-cysteine; NO; SHBG; vitamin D
ID D-BINDING PROTEIN; OXIDATIVE STRESS; INSULIN-RESISTANCE;
   N-ACETYLCYSTEINE; NITRIC-OXIDE; IN-VIVO; DIETARY SUPPLEMENTATION;
   GLYCATED HEMOGLOBIN; GLUCOSE-METABOLISM; PLASMA GLUTATHIONE
AB Vitamin D receptors are expressed in many organs and tissues, which suggests that vitamin D (VD) affects physiological functions beyond its role in maintaining bone health. Deficiency or inadequacy of 25(OH)VD is widespread globally. Population studies demonstrate that a positive association exists between a high incidence of VD deficiency and a high incidence of chronic diseases, including dementia, diabetes, and heart disease. However, many subjects have difficulty achieving the required circulating levels of 25(OH)VD even after high-dose VD supplementation, and randomized controlled clinical trials have reported limited therapeutic success post-VD supplementation. Thus, there is a discordance between the benefits of VD supplementation and the prevention of chronic diseases in those with VD deficiency. Why this dissociation exists is currently under debate and is of significant public interest. This review discusses the downregulation of VD-metabolizing genes needed to convert consumed VD into 25(OH)VD to enable its metabolic action exhibited by subjects with metabolic syndrome, obesity, and other chronic diseases. Research findings indicate a positive correlation between the levels of 25(OH)VD and glutathione (GSH) in both healthy and diabetic individuals. Cell culture and animal experiments reveal a novel mechanism through which the status of GSH can positively impact the expression of VD metabolism genes. This review highlights that for better success, VD deficiency needs to be corrected at multiple levels: (i) VD supplements and/or VD-rich foods need to be consumed to provide adequate VD, and (ii) the body needs to be able to upregulate VD-metabolizing genes to convert VD into 25(OH)VD and then to 1,25(OH)2VD to enhance its metabolic action. This review outlines the association between 25(OH)VD deficiency/inadequacy and decreased GSH levels, highlighting the positive impact of combined VD+LC supplementation on upregulating GSH, VD-metabolizing genes, and VDR. These effects have the potential to enhance 25(OH)VD levels and its therapeutic efficacy.
C1 [Jain, Sushil K.; Margret, Jeffrey Justin] Louisiana State Univ, Dept Pediat, Hlth Sci Ctr, Shreveport, LA 71103 USA.
   [Abrams, Steven A.] Univ Texas Austin, Dept Pediat, Dell Med Sch, Austin, TX 78723 USA.
   [Abrams, Steven A.] Univ Texas Austin, Dell Pediat Res Inst, Dell Med Sch, Austin, TX 78723 USA.
   [Levine, Steven N.; Bhusal, Kamal] Louisiana State Univ, Hlth Sci Ctr, Dept Med, Shreveport, LA 71103 USA.
C3 Louisiana State University System; Louisiana State University Health
   Sciences Center at Shreveport; University of Texas System; University of
   Texas Austin; University of Texas System; University of Texas Austin;
   Louisiana State University System; Louisiana State University Health
   Sciences Center at Shreveport
RP Jain, SK (corresponding author), Louisiana State Univ, Dept Pediat, Hlth Sci Ctr, Shreveport, LA 71103 USA.
EM sushil.jain@lsuhs.edu; jeffrey.justinmargret@lsuhs.edu;
   sabrams@austin.utexas.edu; steven.levine@lsuhs.edu;
   kamal.bhusal@lsuhs.edu
RI Justin Margret, Jeffrey/GRF-1738-2022
OI Jain, Sushil/0000-0002-9574-0436; Justin Margret,
   Jeffrey/0000-0001-7905-1887
FU National Institute of Health (NIH/NCCIH) [5R33AT010637-01A1, 3R33
   AT010637-02S1]; Malcolm Feist Endowed Chair in Diabetes
FX The authors are supported by grants from the National Institute of
   Health (NIH/NCCIH)-(5R33AT010637-01A1 and 3R33 AT010637-02S1) and the
   Malcolm Feist Endowed Chair in Diabetes.
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NR 157
TC 6
Z9 6
U1 2
U2 3
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JUL
PY 2024
VL 16
IS 13
AR 2004
DI 10.3390/nu16132004
PG 20
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA YS5H6
UT WOS:001270481000001
PM 38999752
OA gold
DA 2025-06-11
ER

PT J
AU Naz, MSG
   Farhadi-Azar, M
   Noroozzadeh, M
   Farahmand, M
   Tehrani, FR
AF Naz, Marzieh Saei Ghare
   Farhadi-Azar, Mahbanoo
   Noroozzadeh, Mahsa
   Farahmand, Maryam
   Tehrani, Fahimeh Ramezani
TI Follicle-Stimulating Hormone and Diabetes in Postmenopausal Women: A
   Systematic Review and Meta-Analysis
SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Review
DE follicle-stimulating hormone; menopause; diabetes mellitus; women
ID EARLY MENOPAUSAL TRANSITION; POPULATION-BASED COHORT; RISK-FACTORS;
   METABOLIC SYNDROME; OXIDATIVE STRESS; SEX-HORMONES; ESTRADIOL;
   ASSOCIATION; FSH; ATHEROSCLEROSIS
AB Context The co-occurrence of hormonal changes during menopause and the risk of cardio-metabolic disorders has been well studied.Objective We explored the association of circulating levels of follicle-stimulating hormone (FSH) with diabetes (DM) among postmenopausal women.Method In this systematic review and meta-analysis, the search was performed in PubMed, Scopus, Web of Sciences, Epistemonikos, and Cochrane Library up to September 2023. Risk of bias was assessed by Newcastle-Ottawa Quality Assessment Scale. Pooled estimates of mean differences in FSH levels were compared between postmenopausal women with and without DM. Correlations between FSH and fasting blood glucose (FBG)/insulin/homeostatic model assessment for insulin resistance (HOMA-IR) as well as pooled effect sizes with their 95% CIs for risk of DM were calculated.Results In this study, 14 articles, including 7878 postmenopausal women, met eligibility criteria. Most of the included studies had a low/moderate risk of bias. Women with DM had significantly lower FSH levels than those without DM (standardized mean difference [SMD] -0.751 [95% CI, -1.129 to -.372], I2 = 82.46%, n = 1416). The pooled effect size for diabetes was 0.861 (95% CI, 0.740-1.001; I2 = 80.11%). The pooled risk estimate for DM based on the categorical FSH levels (high vs low) was (HR = 0.550; 95% CI, 0.356-0.850, I2 = 0). The significant inverse correlation was found between FSH levels and glycemic parameters: FBG (r= -0.285 [95% CI -0.441 to -0.113]; n = 1229), HOMA-IR (r = -0.241[-0.378 to -0.0924]; n = 1229) and insulin (r = -0.337 [-0.434 to -0.232]; n = 959)]. There were no statistically significant differences between estradiol levels among diabetic and nondiabetic groups; however, the SMD for luteinizing hormone was similar to that reported for FSH.Conclusion The available data indicated an indirect association between FSH levels and glucose disturbances among postmenopausal women, notwithstanding heterogeneity among included studies, and the complexity of various influential factors needs to be considered. Further efforts should be made to clarify the underlying mechanisms.
C1 [Naz, Marzieh Saei Ghare; Farhadi-Azar, Mahbanoo; Noroozzadeh, Mahsa; Farahmand, Maryam; Tehrani, Fahimeh Ramezani] Shahid Beheshti Univ Med Sci, Res Inst Endocrine Sci, Reprod Endocrinol Res Ctr, 24,Arabi Ave,Yaman St, Tehran 1985717413, Iran.
   [Tehrani, Fahimeh Ramezani] Fdn Res & Educ Excellence, Vestavia, AL 35243 USA.
C3 Shahid Beheshti University Medical Sciences
RP Tehrani, FR (corresponding author), Fdn Res & Educ Excellence, Vestavia, AL 35243 USA.
EM fah.tehrani@gmail.com
RI Naz, Marzieh/K-8811-2019; Azar, Mahbanoo/ACE-7591-2022; Tehrani,
   Fahimeh/H-6133-2017; Noroozzadeh, Mahsa/K-4765-2017; Farahmand,
   Maryam/K-4678-2017
OI Ramezani Tehrani, Fahimeh/0000-0002-4609-065X; Farhadi-Azar,
   Mahbanoo/0000-0003-3769-5160
FU Research Institute for Endocrine Sciences, Shahid Beheshti University of
   Medical Sciences, Tehran, Iran [4-43007433]
FX This study funded by the Research Institute for Endocrine Sciences,
   Shahid Beheshti University of Medical Sciences, Tehran, Iran (Grant
   number: 4-43007433).
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SN 0021-972X
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PD APR 24
PY 2024
VL 109
IS 8
BP 2149
EP 2160
DI 10.1210/clinem/dgae198
EA MAR 2024
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA YO7U3
UT WOS:001207390500001
PM 38553980
DA 2025-06-11
ER

PT J
AU Liu, Y
   Azad, MA
   Kong, XF
   Zhu, Q
   Yu, ZG
AF Liu, Yang
   Azad, Md. Abul Kalam
   Kong, Xiangfeng
   Zhu, Qian
   Yu, Zugong
TI Dietary bile acids supplementation modulates immune response,
   antioxidant capacity, glucose, and lipid metabolism in normal and
   intrauterine growth retardation piglets
SO FRONTIERS IN NUTRITION
LA English
DT Article
DE antioxidant capacity; bile acid; intrauterine growth retardation;
   immunity; oxidative stress; weaned piglets
ID LIVER; FXR
AB Intrauterine growth retardation (IUGR) results in intestinal dysfunction contributing to metabolic syndrome and growth lag of piglets. Bile acid (BA) presents various bioactivities, including regulation roles in antioxidant, anti-inflammation, and glucose and lipid metabolism. Forty-eight weaned piglets were allocated to four groups in a 2 x 2 factorial arrangement with the effects of BA supplementation and IUGR challenge. Twenty-four IUGR piglets and 24 normal birth weight (NBW) piglets were allocated into two groups, respectively, including the control group fed with a basal diet, and the treatment group fed a basal diet supplemented with 400 mg/kg BA. The experiment lasted 28 days. The results indicated that BA improved liver and spleen indexes in IUGR piglets, whereas decreased blood RDW-CV and RDW-SD regardless of IUGR (P < 0.05). Dietary BA supplementation decreased plasma CAT activity and liver GSH concentration regardless of IUGR, whereas increased plasma GSH and liver H2O2 and decreased liver T-AOC in weaned piglets (P < 0.05). In addition, IUGR downregulated liver Nrf1 and Nrf2 expression levels, while BA supplementation upregulated the Nrf2 expression of liver in weaned piglets (P < 0.05). Dietary BA decreased (P < 0.05) jejunal GSH concentration and ileal CAT activity regardless of IUGR. Furthermore, IUGR upregulated (P < 0.05) jejunal SOD and CAT expression levels; however, dietary BA upregulated ileal Nrf1 (P < 0.05) and Keap1 (P = 0.07) expression levels in piglets regardless of IUGR. Moreover, IUGR upregulated the liver lipid synthesis (FAS) and downregulated HSL and SCD1 expression levels, while dietary BA downregulated liver FAS and SCD1 expression levels (P < 0.05). However, BA supplementation could enhance liver gluconeogenesis by upregulating (P < 0.05) the liver G6PC and PCK1 expression levels in the NBW piglets but not in the IUGR piglets. Collectively, these findings suggest that BA could regulate the redox status of weaned piglets by regulating the Nrf2/Keap1 pathway and improving liver glucose and lipid metabolism of IUGR piglets. These findings will provide a reference for the application of BA in swine production; moreover, considering the physiological similarity between pigs and humans, these findings will provide a reference for IUGR research in humans.
C1 [Liu, Yang; Kong, Xiangfeng; Yu, Zugong] Nanjing Agr Univ, Coll Vet Med, Nanjing, Peoples R China.
   [Liu, Yang; Azad, Md. Abul Kalam; Kong, Xiangfeng; Zhu, Qian] Chinese Acad Sci, Inst Subtrop Agr, Key Lab Agroecol Proc Subtrop Reg, Hunan Prov Key Lab Anim Nutr Physiol & Metab Proc, Changsha, Peoples R China.
C3 Nanjing Agricultural University; Chinese Academy of Sciences; Institute
   of Subtropical Agriculture, CAS
RP Kong, XF; Yu, ZG (corresponding author), Nanjing Agr Univ, Coll Vet Med, Nanjing, Peoples R China.; Kong, XF (corresponding author), Chinese Acad Sci, Inst Subtrop Agr, Key Lab Agroecol Proc Subtrop Reg, Hunan Prov Key Lab Anim Nutr Physiol & Metab Proc, Changsha, Peoples R China.
EM nnkxf@isa.ac.cn; yuzugong@njau.edu.cn
RI Azad, Md. Abul Kalam/N-2044-2018
OI Azad, Md. Abul Kalam/0000-0003-0118-5708
FU National Natural Science Foundation of China; China Agriculture Research
   System of MOF and MARA [U20A2056]; Special Funds for Construction of
   Innovative Provinces in Hunan Province [CARS-35];  [2019RS3022]
FX This study was jointly supported by the National Natural Science
   Foundation of China (U20A2056), China Agriculture Research System of MOF
   and MARA (CARS-35), and Special Funds for Construction of Innovative
   Provinces in Hunan Province (2019RS3022).
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NR 35
TC 12
Z9 13
U1 1
U2 28
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD SEP 21
PY 2022
VL 9
AR 991812
DI 10.3389/fnut.2022.991812
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 5D1UE
UT WOS:000864734900001
PM 36211492
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Casimiro, I
   Stull, ND
   Tersey, SA
   Mirmira, RG
AF Casimiro, Isabel
   Stull, Natalie D.
   Tersey, Sarah A.
   Mirmira, Raghavendra G.
TI Phenotypic sexual dimorphism in response to dietary fat manipulation in
   C57BL/6J mice
SO JOURNAL OF DIABETES AND ITS COMPLICATIONS
LA English
DT Article
DE Sexual dimorphism; Obesity; High fat diet; Western diet; C57BL/6J
ID BETA-CELL FAILURE; INDUCED OBESITY; BODY-WEIGHT; MOUSE; METABOLISM;
   ACTIVATION; STRESS; GENDER; MODELS
AB Background: Obesity and the metabolic syndrome are increasingly prevalent in society and their complications and response to treatment exhibit sexual dimorphism. Mouse models of high fat diet-induced obesity are commonly used for both mechanistic and therapeutic studies of metabolic disease and diabetes. However, the inclusion of female mammals in obesity research has not been a common practice, and has resulted in a paucity of data regarding the effect of sex on metabolic parameters and its applicability to humans.
   Methods: Here we analyzed male and female C57BLI6 J mice beginning at 4 weeks of age that were placed on a low-fat diet (LFD, 10% calories from fat), a Western Diet (WD, 45% calories from fat), or a high fat diet (HFD, 60% calories from fat). Assessments of body composition, glucose homeostasis, insulin production, and energy metabolism, as well as histological analyses of pancreata were performed.
   Results: Both male and female C57BL/6 J mice had similar increases in total percent body weight gain with both WD and HFD compared to LFD, however, male mice gained weight earlier upon HFD or WD feeding compared to female mice. Male mice maintained their caloric food intake while reducing their locomotor activity with either WD or HFD compared to LFD, whereas female mice increased their caloric food intake with WD feeding. Locomotor activity of female mice did not significantly change upon WD or HFD feeding, yet female mice exhibited increased energy expenditure compared to WD or HFD fed male mice. Glucose tolerance tests performed at 4. 12 and 20 weeks of dietary intervention revealed impaired glucose tolerance that was worse in male mice compared to females. Furthermore, male mice exhibited an increase in pancreatic beta cell area as well as reduced insulin sensitivity alter HFD feeding compared to WD or LFD, whereas female mice did not.
   Conclusions: Male and female CS7BL/6 J mice exhibited strikingly different responses in weight, food consumption, locomotor activity, energy expenditure and beta 1.5 cell adaptation upon dietary manipulation, with the latter exhibiting less striking phenotypic changes. We conclude that the nature of these responses emphasizes the need to contextualize studies of obesity pathophysiology and treatment with respect to sex. (C) 2020 The Authors.
C1 [Casimiro, Isabel; Tersey, Sarah A.; Mirmira, Raghavendra G.] Univ Chicago, Sect Endocrinol Diabet & Metab, Dept Med, Chicago, IL 60637 USA.
   [Stull, Natalie D.] Indiana Biosci Res Inst, Indianapolis, IN 46202 USA.
C3 University of Chicago
RP Tersey, SA; Mirmira, RG (corresponding author), Univ Chicago, Sect Endocrinol Diabet & Metab, Dept Med, Chicago, IL 60637 USA.
EM stersey@uchicago.edu; mirmira@uchicago.edu
RI Mirmira, Raghavendra/AAD-7592-2020; Casimiro, Isabel/Y-6425-2019
OI Tersey, Sarah/0000-0003-0667-2361
FU National Institutes of Health grants [R01 DK060581, R01 DK124906];
   Indiana Biosciences Research Institute; National Institutes of Health
   [P30 DK097512, P30 DK020595, T32DK007011]
FX Thiswork was supported by National Institutes of Health grants R01
   DK060581, R01 DK124906 and by the Indiana Biosciences Research Institute
   (to RGM). This study utilized core resources provided by National
   Institutes of Health grants P30 DK097512 (to Indiana University), P30
   DK020595 (to University of Chicago) and T32DK007011 (to IC).
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NR 50
TC 124
Z9 133
U1 3
U2 7
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1056-8727
EI 1873-460X
J9 J DIABETES COMPLICAT
JI J. Diabetes Complications
PD FEB
PY 2021
VL 35
IS 2
AR 107795
DI 10.1016/j.jdiacomp.2020.107795
EA JAN 2021
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA PU7AP
UT WOS:000609452700001
PM 33308894
OA hybrid, Green Accepted, Green Submitted
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Qiu, Y
   Deng, X
   Sha, YJ
   Wu, XN
   Zhang, PP
   Chen, K
   Zhao, ZC
   Wei, WP
   Yang, L
   Yuan, GY
   Zhao, L
   Wang, D
AF Qiu, Yue
   Deng, Xia
   Sha, Yujing
   Wu, Xunan
   Zhang, Panpan
   Chen, Ke
   Zhao, Zhicong
   Wei, Weiping
   Yang, Ling
   Yuan, Guoyue
   Zhao, Li
   Wang, Dong
TI Visceral Fat Area, Not Subcutaneous Fat Area, is Associated with Cardiac
   Hemodynamics in Type 2 Diabetes
SO DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
LA English
DT Article
DE cardiac hemodynamics; left ventricular mass index; type 2 diabetes
   mellitus; visceral fat area
ID EPICARDIAL ADIPOSE-TISSUE; INSULIN-RESISTANCE; CARDIOVASCULAR-DISEASE;
   METABOLIC SYNDROME; OXIDATIVE STRESS; HYPERTENSION; ADULTS; MELLITUS;
   OBESITY; RISK
AB Background: This study was conducted in patients with type 2 diabetes mellitus (T2DM) to assess the association between visceral fat area (VFA) and cardiac hemodynamics.
   Methods: A total of 568 patients with type 2 diabetes (mean age 5412 years; 40.8% of women) were enrolled. Visceral fat area (VFA, m2) and subcutaneous fat area (SFA, m2) were evaluated by a bioelectrical impedance analyzer. Cardiac hemodynamics were measured by echocardiography, and other clinical and laboratory variables were also assessed and recorded. Patients were divided into those with VFA <= 100 (n=369) and those with VFA > 100 (n=199).
   Results: VFA, SFA, LVMI (left ventricular mass index), left atrial diameter, left ventricular diastolic diameter (LvDd), interventricular septal thickness (IVST), left ventricular systolic diameter (LvSd), and posterior wall thickness (PWT) levels in high-V groups were signifi-cantly higher than those in low-V groups. Correlation analysis showed that VFA was positively correlated with LVMI (r=0.120, p=0.004), LVM (r=0.249, p<0.0001), left atrial diameter (r=0.375, p<0.0001), aortic root diameter (r=0.243, p<0.0001), left ventricular systolic diameter (LvSd) (r=0.211, p<0.0001) and negatively correlated with LVEF (r= -0.107, p=0.011). In multivariate linear regression analysis, VFA was the strongest independent determinant of LVMI (beta=0.04, p=0.016), LVEF (beta=-0.01, p=0.023), and left atrial diameter (beta=0.035, p<0.0001), Internal diameter of the aortic root (beta=0.014, p<0.0001) and LvSd (beta=0.017, p<0.0001). In addition, the VFA also better predicted cardiovascular disease risk with AUC of 0.609 (95% CI:0.563-0.656), compared with SFA, waist-hip ratio (WHR), in a statistically significant manner.
   Conclusion: We found a significant correlation between VFA (but not SFA) and cardiac hemodynamic parameters. The VFA has advantages as a predictor of visceral obesity and is significantly associated with the development of cardiovascular risk factors (CVD) in T2DM patients.
C1 [Qiu, Yue; Deng, Xia; Sha, Yujing; Wu, Xunan; Zhang, Panpan; Chen, Ke; Zhao, Zhicong; Wei, Weiping; Yang, Ling; Yuan, Guoyue; Zhao, Li; Wang, Dong] Jiangsu Univ, Affiliated Hosp, Dept Endocrinol, 438 Jiefang Rd, Zhenjiang 212001, Jiangsu, Peoples R China.
C3 Jiangsu University
RP Zhao, L; Wang, D (corresponding author), Jiangsu Univ, Affiliated Hosp, Dept Endocrinol, 438 Jiefang Rd, Zhenjiang 212001, Jiangsu, Peoples R China.
EM zhaoli863@163.com; zjdongdonghao@aliyun.com
RI qiu, yue/IAN-7956-2023
FU National Natural Science Foundation of China [81870548, 81570721,
   82000809]; Social Development Project of Jiangsu Province [BE2018692];
   Natural Science Foundation of Jiangsu Province, China [BK20191222];
   Fifth "169 project" Scientific Research Project of Zhenjiang City,
   Jiangsu Province; Social Development Project of Zhenjiang City, Jiangsu
   Province [SH2019041]; Scientific Research Projects of Jiangsu Health and
   Family Planning Commission [Y2018109]
FX This study was supported in part by grants from the National Natural
   Science Foundation of China (81870548, 81570721, 82000809), the Social
   Development Project of Jiangsu Province (BE2018692), the Natural Science
   Foundation of Jiangsu Province, China (BK20191222), the Fifth "169
   project" Scientific Research Project of Zhenjiang City, Jiangsu
   Province, and the Social Development Project of Zhenjiang
   City(SH2019041), Jiangsu Province. The Scientific Research Projects of
   Jiangsu Health and Family Planning Commission (Y2018109).
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NR 40
TC 17
Z9 17
U1 0
U2 9
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-7007
J9 DIABET METAB SYND OB
JI Diabetes Metab. Syndr. Obes.
PY 2020
VL 13
BP 4413
EP 4422
DI 10.2147/DMSO.S284420
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA OS5LJ
UT WOS:000590205000012
PM 33235479
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Ushiroda, C
   Naito, Y
   Takagi, T
   Uchiyama, K
   Mizushima, K
   Higashimura, Y
   Yasukawa, Z
   Okubo, T
   Inoue, R
   Honda, A
   Matsuzaki, Y
   Itohl, Y
AF Ushiroda, Chihiro
   Naito, Yuji
   Takagi, Tomohisa
   Uchiyama, Kazuhiko
   Mizushima, Katsura
   Higashimura, Yasuki
   Yasukawa, Zenta
   Okubo, Tsutomu
   Inoue, Ryo
   Honda, Akira
   Matsuzaki, Yasushi
   Itohl, Yoshito
TI Green tea polyphenol (epigallocatechin-3-gallate) improves gut dysbiosis
   and serum bile acids dysregulation in high-fat diet-fed mice
SO JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION
LA English
DT Article
DE Akkermansia; dysbiosis; epigallocatechin-3-gallate; high-fat diet;
   taurine-conjugated bile acids
ID AKKERMANSIA-MUCINIPHILA; METABOLIC SYNDROME; OXIDATIVE STRESS; INDUCED
   OBESITY; LIVER-DISEASE; MICROBIOTA; (-)-EPIGALLOCATECHIN-3-GALLATE;
   INFLAMMATION; FIBROSIS; OLIGOSACCHARIDES
AB Gut microbiota have profound effects on bile acid metabolism by promoting deconjugation, dehydrogenation, and dehydroxylation of primary bile acids in the distal small intestine and colon. High-fat diet-induced dysbiosis of gut microbiota and bile acid dysregulation may be involved in the pathology of steatosis in patients with non-alcoholic fatty liver disease. Epigallocatechin-3-gallate (EGCG), the most abundant polyphenolic catechin in green tea, has been widely investigated for its inhibitory or preventive effects against fatty liver. The aim of the present study was to investigate the effects of EGCG on the abundance of gut microbiota and the composition of serum bile acids in high-fat diet-fed mice and determine the specific bacterial genera that can improve the serum bile acid dysregulation associated with EGCG anti-hepatic steatosis action. Male C57BL/6N mice were fed with the control diet, high-fat diet, or high-fat diet + EGCG at a concentration of 0.32% for 8 weeks. EGCG significantly inhibited the increases in weight, the area of fatty lesions, and the triglyceride content in the liver induced by the high-fat diet. Principal coordinate analysis revealed significant differences in microbial structure among the groups. At the genus level, EGCG induced changes in the microbiota composition in high-fat diet-fed mice, showing a significantly higher abundance of Adlercreutzia, Akkermansia, Allobaculum and a significantly lower abundance of Desulfovibrionaceae. EGCG significantly reversed the decreased population of serum primary cholic acid and beta-muricholic acid as well as the increased population of taurine-conjugated cholic acid, beta-muricholic acid and deoxycholic acid in high-fat diet-fed mice. Finally, the correlation analysis between bile acid profiles and gut microbiota demonstrated the contribution of Akkermansia and Desulfovibrionaceae in the improvement of bile acid dysregulation in high-fat diet-fed mice by treatment with EGCG. In conclusion, the present study suggests that EGCG could alter bile acid metabolism, especially taurine deconjugation, and suppress fatty liver disease by improving the intestinal luminal environment.
C1 [Ushiroda, Chihiro; Naito, Yuji; Takagi, Tomohisa; Uchiyama, Kazuhiko; Mizushima, Katsura; Itohl, Yoshito] Kyoto Prefectural Univ Med, Grad Sch Med Sci, Mol Gastroenterol & Hepatol, Kamigyo Ku, 465 Kajii Cho, Kyoto 6028566, Japan.
   [Higashimura, Yasuki] Ishikawa Prefectural Univ, Dept Food Sci, 1-308 Suematsu, Nonoichi, Ishikawa 9218836, Japan.
   [Yasukawa, Zenta; Okubo, Tsutomu] Taiyo Kagaku Co Ltd, Nutr Div, 1-3 Takaramachi, Yokaichi, Mie 5100844, Japan.
   [Inoue, Ryo] Kyoto Prefectural Univ, Dept Agr & Life Sci, Lab Anim Sci, Sakyo Ku, 1-5 Shimogamohangi Cho, Kyoto 6068522, Japan.
   [Honda, Akira; Matsuzaki, Yasushi] Tokyo Med Univ, Ibaraki Med Ctr, Gastroenterol, 3-20-1 Ami Machi Chuo, Ibaraki 3000395, Japan.
C3 Kyoto Prefectural University of Medicine; Ishikawa Prefectural
   University; TAIYO KAGAKU CO., LTD.; Kyoto Prefectural University; Tokyo
   Medical University
RP Naito, Y (corresponding author), Kyoto Prefectural Univ Med, Grad Sch Med Sci, Mol Gastroenterol & Hepatol, Kamigyo Ku, 465 Kajii Cho, Kyoto 6028566, Japan.
EM ynaito@koto.kpu-m.ac.jp
RI Honda, Akira/ACN-8249-2022
OI Honda, Akira/0000-0003-0902-8272
FU JSPS KAKENHI [JP 16H05289]; Ministry of Agriculture, Forestry and
   Fisheries of Japan [16824414]
FX This work was supported by Grants-in-Aid for Scientific Research (B)
   (JSPS KAKENHI) to YN (Grant Number JP 16H05289) and by Grant of
   Industry-Academia-Government Collaboration of "Field for Knowledge
   Integration and Innovation" (FKII) to YN (No. 16824414) from the
   Ministry of Agriculture, Forestry and Fisheries of Japan.
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NR 54
TC 111
Z9 117
U1 8
U2 95
PU JOURNAL CLINICAL BIOCHEMISTRY & NUTRITION
PI KYOTO
PA KYOTO PREFECTURAL UNIV MED, GRAD SCH MEDICAL SCIENCE, DEPT MOLECULAR
   GASTROENTEROLOGY & HEPATOLOGY, KYOTO, 602-8566, JAPAN
SN 0912-0009
EI 1880-5086
J9 J CLIN BIOCHEM NUTR
JI J. Clin. Biochem. Nutr.
PD JUL 1
PY 2019
VL 65
IS 1
BP 34
EP 46
DI 10.3164/jcbn.18-116
PG 13
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA IM0QI
UT WOS:000477692900006
PM 31379412
OA gold, Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Gegotek, A
   Domingues, P
   Wronski, A
   Wójcik, P
   Skrzydlewska, E
AF Gegotek, Agnieszka
   Domingues, Pedro
   Wronski, Adam
   Wojcik, Piotr
   Skrzydlewska, Elzbieta
TI Proteomic plasma profile of psoriatic patients
SO JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
LA English
DT Article
DE Psoriasis; Proteome; 4-HNE-protein adducts; Plasma
ID MATRIX METALLOPROTEINASES; TRANSCRIPTION FACTORS; METABOLIC SYNDROME;
   OXIDATIVE STRESS; BINDING PROTEINS; CELL-MIGRATION; SKIN-DISEASE;
   EXPRESSION; INFLAMMATION; PATHOGENESIS
AB Background: Psoriasis is a chronic, immune-mediated inflammatory skin disease with severe consequences for the whole organism. The lack of complete knowledge of the main factors predisposing an individual to the appearance of psoriatic lesions, has recently led to the search for modifications in biochemical pathways participating in the development of this disease. We therefore aimed to investigate changes in the plasma proteomic profile of patients with psoriasis.
   Material and methods: A proteomics approach was used to analyze the expression of proteins in plasma from psoriatic patients and healthy controls (sex- and age-matched individuals). The analysis was performed using gel electrophoresis, followed by nanoflow LC-MS/MS using a Q-Exactive OrbiTrap mass spectrometer.
   Results: Proteomic data indicated a significant decrease in the level of proteins involved in lipid metabolism, such as apolipoprotein M, and proteins involved in the management of vitamin D levels in psoriatic patients' plasma. These changes were accompanied by the expression of proteins involved in immune response and signal transduction. This was particularly evident by the level of transcriptional factors, including AT motif binding factor 1, which regulates excessive cellular proliferation and differentiation. It was also suggested that psoriasis development was associated with increased expression of proteins directly involved in signaling molecule secretion [biotinidase and BAI1-associated protein 3]. In addition, the lipid peroxidation product - 4-hydroxynonenal (4-HNE) generates higher level of adducts with proteins in the plasma of psoriatic patients. Moreover, plasma proteins from healthy subjects creating with 4-HNE adducts were mainly characterized as structural, while in the plasma of psoriatic patients, increased levels of 4-HNE-protein adducts with catalytic activity were observed.
   Conclusion: The results presented herein confirm the current knowledge about the profile of proteins responsible for the immune response and management of vitamin D in the plasma of psoriatic patients. However, several new proteins were also identified, which are involved in signal transduction and lipid metabolism as well as catalytic activity. The expression or structure of these proteins was shown to change through the course of the development of psoriasis. This knowledge may help contribute to the design of more specific pharmacotherapy. (C) 2018 Elsevier B.V. All rights reserved.
C1 [Gegotek, Agnieszka; Wojcik, Piotr; Skrzydlewska, Elzbieta] Med Univ Bialystok, Dept Analyt Chem, Bialystok, Poland.
   [Domingues, Pedro] Univ Aveiro, Dept Chem, Mass Spectrometry Ctr, QOPNA, Aveiro, Portugal.
   [Wronski, Adam] Dermatol Specialized Ctr DERMAL NZOZ Bialystok, Bialystok, Poland.
C3 Medical University of Bialystok; Universidade de Aveiro
RP Skrzydlewska, E (corresponding author), Med Univ Bialystok, Mickiewicza 2D, PL-15222 Bialystok, Poland.
EM elzbieta.skrzydlewska@umb.edu.pl
RI Gęgotek, Agnieszka/GVU-1667-2022; Domingues, Pedro/E-5202-2010
OI Gegotek, Agnieszka/0000-0002-5240-1346; Domingues,
   Pedro/0000-0002-8060-7675; Skrzydlewska, Elzbieta/0000-0001-5397-7139;
   Wojcik, Piotr/0000-0002-4455-3788
FU National Science Centre Poland (NCN) [2016/23/B/NZ7/02350]; Medical
   University of Bialystok as part of the OP DEP [POPW.01.03.00-20-022/09];
   FCT/MEC [UID/QUI/00062/2013]; FEDER within the PT2020 Partnership
   Agreement; Mass Spectrometry Network [REDE/1504/REM/2005]
FX This study was financed by the National Science Centre Poland (NCN)
   grant no. 2016/23/B/NZ7/02350 and was conducted with the use of
   equipment purchased by the Medical University of Bialystok as part of
   the OP DEP 2007-2013, Priority Axis I.3, contract No.
   POPW.01.03.00-20-022/09. Thanks are due FCT/MEC for the financial
   support to QOPNA (UID/QUI/00062/2013), at University of Aveiro through
   national funds, and the co-funding by the FEDER, within the PT2020
   Partnership Agreement and to Mass Spectrometry Network
   (REDE/1504/REM/2005).
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   Zhou Q, 2009, FREE RADICAL BIO MED, V47, P891, DOI 10.1016/j.freeradbiomed.2009.06.033
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NR 75
TC 53
Z9 53
U1 0
U2 17
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0731-7085
EI 1873-264X
J9 J PHARMACEUT BIOMED
JI J. Pharm. Biomed. Anal.
PD JUN 5
PY 2018
VL 155
BP 185
EP 193
DI 10.1016/j.jpba.2018.03.068
PG 9
WC Chemistry, Analytical; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Pharmacology & Pharmacy
GA GH2YK
UT WOS:000433267700022
PM 29635173
DA 2025-06-11
ER

PT J
AU Fond, G
   Resseguier, N
   Schürhoff, F
   Godin, O
   Andrianarisoa, M
   Brunel, L
   Bulzacka, E
   Aouizerate, B
   Berna, F
   Capdevielle, D
   Chereau, I
   D'Amato, T
   Dubertret, C
   Dubreucq, J
   Faget, C
   Gabayet, F
   Lançon, C
   Llorca, PM
   Mallet, J
   Misdrahi, D
   Passerieux, C
   Rey, R
   Schandrin, A
   Urbach, M
   Vidailhet, P
   Boyer, L
   Leboyer, M
AF Fond, G.
   Resseguier, N.
   Schurhoff, F.
   Godin, O.
   Andrianarisoa, M.
   Brunel, L.
   Bulzacka, E.
   Aouizerate, B.
   Berna, F.
   Capdevielle, D.
   Chereau, I
   D'Amato, T.
   Dubertret, C.
   Dubreucq, J.
   Faget, C.
   Gabayet, F.
   Lancon, C.
   Llorca, P. M.
   Mallet, J.
   Misdrahi, D.
   Passerieux, C.
   Rey, R.
   Schandrin, A.
   Urbach, M.
   Vidailhet, P.
   Boyer, L.
   Leboyer, M.
CA FACE-SZ FondaMental Acad Ctr Exper
TI Relationships between low-grade peripheral inflammation and psychotropic
   drugs in schizophrenia: results from the national FACE-SZ cohort
SO EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
LA English
DT Article
DE Schizophrenia; Inflammation; Antipsychotic; Antidepressant; Valproate
ID C-REACTIVE PROTEIN; RANDOMIZED CONTROLLED-TRIALS; VALPROIC ACID;
   OXIDATIVE STRESS; PROINFLAMMATORY CYTOKINES; ANTIINFLAMMATORY DRUGS;
   ANTIPSYCHOTIC-DRUGS; METABOLIC SYNDROME; BIPOLAR DISORDER; IN-VITRO
AB Low-grade inflammation has repeatedly been associated with schizophrenia (SZ) and in particular with cognitive impairment. Female gender, overweight and tobacco smoking have been suggested as risk factors to increase inflammation while preclinical inconsistent findings have been found regarding the association with psychotropic drugs. The aim of this study was to explore if psychotropic drugs were associated with inflammation in SZ and to determine which psychotropic drug was associated with inflammation in stable SZ subjects while considering clinical confounding factors. Participants were consecutively included in the network of the FondaMental Expert Centers for Schizophrenia and received a thorough clinical assessment, including recording of current treatment. High-sensitivity CRP (hs-CRP) was measured for each participant as a proxy to define peripheral low-grade inflammation. The zero-inflated Poisson regression model estimated the relationship between low-grade inflammation and psychotropic drug. Four hundred and five stabilized, community-dwelling SZ subjects (mean age = 32.6 years, 74% male gender) have been included. In total, 148 participants (36.5%) were found with undetectable blood hs-CRP level. The probability of having an undetectable CRP was associated with a lower body mass index (p < 0.0001) and no cyamemazine add-on antipsychotic therapy (p = 0.001). The other 257 participants (63.5%) were found to have low-grade inflammation (hs-CRP > 0 mg/L). Low-grade inflammation was significantly associated with female gender (p = 0.004), higher body mass index (p < 0.0001), current tobacco smoking (p < 0.0001), clomipramine (p = 0.04), quetiapine (p < 0.0001) and hypnotic (p = 0.0006) consumption while decreased hs-CRP blood levels was associated with aripiprazole (p = 0.004) and valproate/valpromide (p = 0.03) consumption. The present study suggests that some psychotropic drugs (quetiapine, cyamemazine, clomipramine) may be associated with increased peripheral low-grade inflammation in SZ patients while others (aripiprazole, valproate) may be associated with decreased peripheral low-grade inflammation. These results should be replicated in SZ and non-SZ populations and the biological underpinnings should be further explored.
C1 [Fond, G.; Resseguier, N.; Schurhoff, F.; Godin, O.; Andrianarisoa, M.; Brunel, L.; Bulzacka, E.; Aouizerate, B.; Berna, F.; Capdevielle, D.; Chereau, I; D'Amato, T.; Dubertret, C.; Dubreucq, J.; Faget, C.; Gabayet, F.; Lancon, C.; Llorca, P. M.; Mallet, J.; Misdrahi, D.; Passerieux, C.; Rey, R.; Schandrin, A.; Urbach, M.; Boyer, L.; Leboyer, M.] Fdn FondaMental, Creteil, France.
   [Fond, G.; Schurhoff, F.; Godin, O.; Andrianarisoa, M.; Brunel, L.; Bulzacka, E.; Leboyer, M.] Equipe Psychiat Translat, INSERM U955, Creteil, France.
   [Fond, G.; Schurhoff, F.; Godin, O.; Andrianarisoa, M.; Brunel, L.; Bulzacka, E.; Leboyer, M.] Univ Paris Est Creteil, Hop Univ H Mondor, DHU Pe PSY, Pole Psychiat, Creteil, France.
   [Resseguier, N.; Boyer, L.] CHU St Marguerite, Pole Psychiat Univ, F-13274 Marseille 09, France.
   [Aouizerate, B.; Misdrahi, D.] Ctr Hosp Charles Perrens, F-33076 Bordeaux, France.
   [Aouizerate, B.; Misdrahi, D.] Univ Bordeaux, F-33000 Bordeaux, France.
   [Berna, F.; Vidailhet, P.] Univ Strasbourg, Hop Univ Strasbourg, INSERM U1114, Federat Med Translat Strasbourg, F-67000 Strasbourg, France.
   [Capdevielle, D.; Schandrin, A.] Univ Montpellier I, CHRU Montpellier, Hop Colombiere, Serv Univ Psychiat Adulte,Inserm 1061, Montpellier, France.
   [Chereau, I; Llorca, P. M.] Univ Auvergne, Fac Med, CHU, CMP B,EA 7280, BP 69, F-63003 Clermont Ferrand 1, France.
   [D'Amato, T.; Rey, R.] Univ Claude Bernard Lyon 1, Equipe PSYR2, Ctr Hosp Le Vinatier, Ctr Rech Neurosci Lyon,INSERM U1028,CNRS UMR5292, 95 Bd Pinel,BP 30039, F-69678 Bron, France.
   [Dubertret, C.; Mallet, J.] Univ Paris Diderot, Sorbonne Paris Cite, AP HP, Louis Mourier Hosp,Fac Med,Dept Psychiat,Inserm U, F-92700 Colombes, France.
   [Dubreucq, J.; Gabayet, F.] CH Alpes Isere, Ctr Referent Rehabil Psychosociale, Grenoble, France.
   [Faget, C.; Lancon, C.] AP HM, Pole Univ Psychiat, Marseille, France.
   [Passerieux, C.; Urbach, M.] Univ Versailles St Quentin Yvelines, UFR Sci Sante Simone Veil, Ctr Hosp Versailles, Serv Psychiat Adulte, Versailles, France.
   [Fond, G.; Resseguier, N.; Schurhoff, F.; Godin, O.; Andrianarisoa, M.; Brunel, L.; Bulzacka, E.; Aouizerate, B.; Berna, F.; Capdevielle, D.; Chereau, I; D'Amato, T.; Dubertret, C.; Dubreucq, J.; Faget, C.; Gabayet, F.; Lancon, C.; Llorca, P. M.; Mallet, J.; Misdrahi, D.; Passerieux, C.; Rey, R.; Schandrin, A.; Urbach, M.; Vidailhet, P.; Boyer, L.; Leboyer, M.] Bordeaux Univ, Pellegrin Univ Hosp, Bordeaux Sleep Clin, USR CNRS SANPSY 3413,Res Unit, F-33000 Bordeaux, France.
   [Aouizerate, B.] Inserm, Neuroctr Magendie Physiopathol Plasticite Neurona, F-33000 Bordeaux, France.
   [Misdrahi, D.] CNRS, UMR INCIA 5287, Bordeaux, France.
   [Fond, G.] Hop A Chenevier, Pole Psychiat, 40 Rue Mesly, F-94010 Creteil, France.
C3 Universite Paris-Est-Creteil-Val-de-Marne (UPEC); Institut National de
   la Sante et de la Recherche Medicale (Inserm); Assistance Publique
   Hopitaux Paris (APHP); Universite Paris-Est-Creteil-Val-de-Marne (UPEC);
   Hopital Universitaire Henri-Mondor - APHP; Aix-Marseille Universite;
   Universite de Bordeaux; CHU Strasbourg; Institut National de la Sante et
   de la Recherche Medicale (Inserm); Universites de Strasbourg
   Etablissements Associes; Universite de Strasbourg; Universite de
   Montpellier; CHU de Montpellier; Institut National de la Sante et de la
   Recherche Medicale (Inserm); Universite Clermont Auvergne (UCA); CHU
   Clermont Ferrand; Centre National de la Recherche Scientifique (CNRS);
   Institut National de la Sante et de la Recherche Medicale (Inserm);
   Universite Claude Bernard Lyon 1; Universite Jean Monnet; CNRS -
   National Institute for Biology (INSB); Institut National de la Sante et
   de la Recherche Medicale (Inserm); Assistance Publique Hopitaux Paris
   (APHP); Universite Paris Cite; Hopital Universitaire Louis-Mourier -
   APHP; Aix-Marseille Universite; Assistance Publique-Hopitaux de
   Marseille; Centre Hospitalier de Versailles; Universite Paris Saclay;
   Centre National de la Recherche Scientifique (CNRS); CNRS - National
   Institute for Biology (INSB); Universite de Bordeaux; CHU Bordeaux;
   Institut National de la Sante et de la Recherche Medicale (Inserm);
   Centre National de la Recherche Scientifique (CNRS); Universite
   Paris-Est-Creteil-Val-de-Marne (UPEC); Assistance Publique Hopitaux
   Paris (APHP); Hopital Universitaire Henri-Mondor - APHP
RP Fond, G (corresponding author), Fdn FondaMental, Creteil, France.; Fond, G (corresponding author), Equipe Psychiat Translat, INSERM U955, Creteil, France.; Fond, G (corresponding author), Univ Paris Est Creteil, Hop Univ H Mondor, DHU Pe PSY, Pole Psychiat, Creteil, France.; Fond, G (corresponding author), Bordeaux Univ, Pellegrin Univ Hosp, Bordeaux Sleep Clin, USR CNRS SANPSY 3413,Res Unit, F-33000 Bordeaux, France.; Fond, G (corresponding author), Hop A Chenevier, Pole Psychiat, 40 Rue Mesly, F-94010 Creteil, France.
EM guillaume.fond@gmail.com
RI Schandrin, Aurélie/ISV-4608-2023; Boyer, Laurent/E-5728-2016; Leboyer,
   Marion/AAW-3648-2021; Mallet, Jasmina/GNP-7160-2022; Berna,
   Fabrice/J-2701-2019; Capdevielle, Delphine/HTO-4229-2023; TESSIER,
   Arnaud/A-4022-2017; FOND, Guillaume/D-7646-2011
OI LEBOYER, Marion/0000-0001-5473-3697; dubreucq,
   julien/0000-0003-4079-4194; Capdevielle, Delphine/0000-0002-7146-8554;
   REY, Romain/0000-0002-4603-3575; Misdrahi, David/0000-0003-1146-3206;
   TESSIER, Arnaud/0000-0001-5758-5693; D'Amato,
   Thierry/0000-0001-8983-0315; Aouizerate, Bruno/0000-0002-7092-7747;
   FOND, Guillaume/0000-0003-3249-2030
FU AP-HP (Assistance Publique des Hopitaux de Paris), Fondation FondaMental
   (RTRS Sante Mentale); Investissements d'Avenir program
   [ANR-11-IDEX-0004-02, ANR-10-COHO-10-01]; INSERM (Institut National de
   la Sante et de la Recherche Medicale)
FX This work was funded by AP-HP (Assistance Publique des Hopitaux de
   Paris), Fondation FondaMental (RTRS Sante Mentale), by the
   Investissements d'Avenir program managed by the ANR under reference
   ANR-11-IDEX-0004-02 and ANR-10-COHO-10-01, and by INSERM (Institut
   National de la Sante et de la Recherche Medicale).
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NR 73
TC 26
Z9 27
U1 0
U2 9
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0940-1334
EI 1433-8491
J9 EUR ARCH PSY CLIN N
JI Eur. Arch. Psych. Clin. Neurosci.
PD SEP
PY 2018
VL 268
IS 6
BP 541
EP 553
DI 10.1007/s00406-017-0847-1
PG 13
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA GQ0CP
UT WOS:000441284300003
PM 29127503
DA 2025-06-11
ER

PT J
AU Ilea, A
   Babtan, AM
   Bosca, BA
   Crisan, M
   Petrescu, NB
   Collino, M
   Sainz, RM
   Gerlach, JQ
   Câmpian, RS
AF Ilea, Aranka
   Babtan, Anida M.
   Bosca, Bianca A.
   Crisan, Maria
   Petrescu, Nausica B.
   Collino, Massimo
   Sainz, Rosa M.
   Gerlach, Jared Q.
   Campian, Radu Septimiu
TI Advanced glycation end products (AGEs) in oral pathology
SO ARCHIVES OF ORAL BIOLOGY
LA English
DT Review
DE Advanced glycation end products - AGEs; Chronic inflammation;
   Diet-related disease; Oral pathology; Salivary biosensor
ID ACCELERATED PERIODONTAL-DISEASE; FACTOR-KAPPA-B; NONENZYMATIC GLYCATION;
   LIPID-PEROXIDATION; SALIVARY MARKERS; OXIDATIVE STRESS; DENTAL-PULP;
   RECEPTOR; COLLAGEN; EXPRESSION
AB Objective: Maillard advanced glycation end products (AGEs) are connected with high dry temperature food processing, color and flavor modification of food products. Oral cavity pathology is strongly influenced by dietary intake. The aim of the present paper is to update current data regarding the sources and metabolism of AGEs, their impact on oral cavity tissues, to discuss and suggest new approaches for the early diagnosis and efficient treatment of AGEs-related oral pathology.
   Design: This paper is a narrative review of the studies discussing AGEs and mainly the dietary AGEs (dAGEs) sources, metabolism, linkage to general diseases, and specifically the oral cavity pathology. The authors used "PUBMED" and MeSH for the finding of English written and published articles concerning AGEs. There were used the next keywords association: "advanced glycation end products-AGEs" AND "Maillard products", "AGEs" AND "diet-related disease, "AGEs" AND "salivary biosensor", "AGEs" AND "metabolic syndrome AGEs", "AGEs" AND "oral pathology", "AGEs" AND "dentin AGEs" OR "periodontal AGEs", "AGEs" AND "diagnosis and monitoring". The authors used free full-text articles to determine the etiology and physiopathology of AGEs, their association with general diseases and oral cavity disease, assessment methods used in biofluids and tissues, AGEs prevention and treatment approaches. Articles concerning AGEs etiology, metabolism and effect in the human body and specific implication in oral pathology were selected. There were no exclusion criteria in what concerns the study design. Studies in other language than English and articles abstracts were excluded.
   Criteria of inclusion were free full-text articles written in English. Equally human and animal model studies were included. Regarding the date of publication, all subjects concerning glycation products after 1953 (first published article) were included.
   Results: Evidence show that AGEs are responsible for inducing low intensity chronic inflammation and thereby, for initiating and/or aggravating chronic diseases. Nowadays, research has demonstrated a significant association between AGEs and dental or periodontal pathology. Moreover, salivary AGEs are consistent with the levels of AGEs in other biological fluids and are correlated with the general and oral pathology. Conclusions: Assessment of salivary AGEs could be a reliable tool for early diagnosis and monitoring diet-related disease.
C1 [Ilea, Aranka; Babtan, Anida M.; Petrescu, Nausica B.; Campian, Radu Septimiu] Iuliu Hatieganu Univ Med & Pharm, Fac Dent, Oral Hlth & Dent Off Management, Dept Oral Rehabil, Cluj Napoca, Romania.
   [Bosca, Bianca A.; Crisan, Maria] Iuliu Hatieganu Univ Med & Pharm, Fac Med, Dept Histol, Cluj Napoca, Romania.
   [Collino, Massimo] Univ Turin, Dept Drug Sci & Technol, Turin, Italy.
   [Sainz, Rosa M.] Univ Oviedo, Dept Morphol & Cell Biol, Oviedo, Spain.
   [Gerlach, Jared Q.] Natl Univ Ireland Galway, Natl Ctr Biomed Engn Sci, Glycosci Grp, Galway, Ireland.
   Str L Pasteur 4, Cluj Napoca 400349, Romania.
C3 Iuliu Hatieganu University of Medicine & Pharmacy; Iuliu Hatieganu
   University of Medicine & Pharmacy; University of Turin; University of
   Oviedo; Ollscoil na Gaillimhe-University of Galway
RP Bosca, BA (corresponding author), Iuliu Hatieganu Univ Med & Pharm, Fac Med, Dept Histol, Cluj Napoca, Romania.
EM aranka.ilea@umfcluj.ro; babtan.anida@umfcluj.ro;
   bianca.bosca@umfcluj.ro; maria.crisan@umfcluj.ro;
   petrescu.bianca@umfcluj.ro; Massimo_collino@unito.it;
   sainzrosa@uniovi.es; jared.gerlach@nuigalway.ie; rcampian@umfcluj.ro
RI Collino, Massimo/AAK-8532-2020; Petrescu, Nausica/ABA-2480-2022; Boșca,
   Bianca/AAS-7779-2021; Babtan, Anida-Maria/AAO-2548-2020; crisan,
   maria/AAA-8119-2021; Ilea, Aranka/N-6040-2014; Sainz, Rosa
   M./N-5885-2014; Gerlach, Jared/K-2698-2013
OI Sainz, Rosa M./0000-0003-3048-5582; Bosca, Adina
   Bianca/0000-0002-3835-2090; Gerlach, Jared/0000-0001-7343-7201
FU "Iuliu Hatieganu" University of Medicine and Pharmacy Cluj-Napoca,
   Romania PhD Grant [3999/01.10.2016]; COFUND-ERA-HDHL ERANET Project,
   European and International Cooperation - Subprogram 3.2 - Horizon 2020,
   PNCDI III Program - Biomarkers for Nutrition and Health-"Innovative
   technological approaches for validation of salivary AGEs as novel
   biomarkers in eval [25/1.09.2017]; European and International
   Cooperation - Subprogram 3.2 - Horizon 2020
FX This study was supported by "Iuliu Hatieganu" University of Medicine and
   Pharmacy Cluj-Napoca, Romania PhD Grant no 3999/01.10.2016, and
   partially by the COFUND-ERA-HDHL ERANET Project, European and
   International Cooperation - Subprogram 3.2 - Horizon 2020, PNCDI III
   Program - Biomarkers for Nutrition and Health-"Innovative technological
   approaches for validation of salivary AGEs as novel biomarkers in
   evaluation of risk factors in diet-related diseases", grant no
   25/1.09.2017.
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NR 72
TC 31
Z9 33
U1 0
U2 35
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0003-9969
EI 1879-1506
J9 ARCH ORAL BIOL
JI Arch. Oral Biol.
PD SEP
PY 2018
VL 93
BP 22
EP 30
DI 10.1016/j.archoralbio.2018.05.013
PG 9
WC Dentistry, Oral Surgery & Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dentistry, Oral Surgery & Medicine
GA GO1AJ
UT WOS:000439677500004
PM 29803117
DA 2025-06-11
ER

PT J
AU Shoeib, S
   Abdel-Atti, E
   Dala, AG
   El-Noamany, M
   Kamal, SM
   Gabr, HM
AF Shoeib, Sabry
   Abdel-Atti, Ehab
   Dala, Ashraf G.
   El-Noamany, Mohamed
   Kamal, Samar M.
   Gabr, Hala M.
TI Is hyperuricaemia one of the cardiovascular risk factors clustering in
   type 2 diabetic patients?
SO LIFE SCIENCE JOURNAL-ACTA ZHENGZHOU UNIVERSITY OVERSEAS EDITION
LA English
DT Article
DE Type 2 diabetes mellitus; hyperuricemia; microangiopathy and ischaemic
   heart disease
ID SERUM URIC-ACID; CORONARY-HEART-DISEASE; METABOLIC SYNDROME; ENDOTHELIAL
   FUNCTION; INSULIN-RESISTANCE; HYPERTENSION; LEVEL; ALLOPURINOL;
   ASSOCIATION; PROGRESSION
AB Background & Aim: The prevalence of hyperuricaemia (HU) in type 2 diabetic patients (T2DM) and its relation with diabetic micro-and macro-vascular complications has been conflicting. The aim of the present study was to investigate the relationship between HU and both micro and macroangiopathies (IHD and diabetic nephropathy and neuropathy) in patients with type 2 diabetes mellitus. Methods: The cohort of this cross-sectional study was sixty T2 diabetic patients (26 men and 34 women, aged 52.4 +/- 8.6 years). They have been recruited from the Outpatient Department of Menofia University Hospital between January and June, 2010. In addition to comprehensive clinical examination, they were subjected to laboratory check-up for serum uric acid, fasting blood glucose (FBG) and postprandial blood glucose (PPBG), glycated hemoglobin A1c (HbA1c), serum lipids, 24-hours urine collection for microalbuminuria (mu A), stress ECG and coronary angiography as indicated. Results: HU was detected in 18 out of out 60 (30%) type 2 diabetic patients. The frequency of hypertension (HT), ischaemic heart disease (IHD), peripheral neuropathy (PN) and mu A were significantly higher in diabetic patients with (78%, 67%, 78% and 78%, respectively) than in those without HU (48%, 5%, 38% and 33% respectively) (P=0.04, 0.0001, 0.01 and 0.001, respectively). We also observed a significantly higher FBG, PPBG and HbA1c in the diabetic patients with compared to those without HU (P=0.02, 0.01 and 0.01 respectively) have. Likewise, total cholesterol, triglyceride (TG) and creatinine levels in diabetic patients with HU were again significantly (P=0.02, 0.001 and 0.001, respectively) above their counterparts values in diabetics without HU. Conclusion: The cheap, basically available and modifiable serum uric acid level we observed to prevail in T2 diabetic patients would be a useful investigational tool to prompt a cost-effective search for other cardiovascular risk factors known to cluster in them. [Sabry Shoeib; Ehab Abdel-Atti; Ashraf G. Dala; Mohamed El-Noamany; Samar M. Kamal and Hala M Gabr. Is hyperuricaemia one of the cardiovascular risk factors clustering in type 2 diabetic patients? Life Sci J 2012;9(3):657-666] (ISSN: 1097-8135). http://www.lifesciencesite.com. 92
C1 [Shoeib, Sabry; Abdel-Atti, Ehab; Dala, Ashraf G.] Menofiya Univ Hosp, Fac Med, Dept Internal Med, Assiut, Egypt.
   [El-Noamany, Mohamed] Menofiya Univ Hosp, Fac Med, Dept Cardiol, Assiut, Egypt.
   [Kamal, Samar M.] Menofiya Univ Hosp, Fac Med, Dept Clin Pathol, Assiut, Egypt.
   [Gabr, Hala M.] Menofiya Univ Hosp, Fac Med, Community Dept, Assiut, Egypt.
C3 Egyptian Knowledge Bank (EKB); Menofia University; Assiut University;
   Egyptian Knowledge Bank (EKB); Assiut University; Menofia University;
   Egyptian Knowledge Bank (EKB); Assiut University; Menofia University;
   Egyptian Knowledge Bank (EKB); Menofia University; Assiut University
RP Shoeib, S (corresponding author), Menofiya Univ Hosp, Fac Med, Dept Internal Med, Assiut, Egypt.
EM ehab_abdelatty@hotmail.com
RI Gabr, Hala/AAC-4053-2021; abdelatti, ehab/AAI-2053-2021
OI Gabr, Hala/0000-0003-0262-8558
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NR 48
TC 1
Z9 1
U1 0
U2 4
PU MARSLAND PRESS
PI LANSING
PA PO BOX 21126, LANSING, MI 48909 USA
SN 1097-8135
J9 LIFE SCI J
JI Life Sci. J.
PY 2012
VL 9
IS 3
BP 657
EP 666
PG 10
WC Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics
GA 100SX
UT WOS:000315724100091
DA 2025-06-11
ER

PT J
AU Dickerson, B
   Maury, J
   Jenkins, V
   Nottingham, K
   Xing, D
   Gonzalez, DE
   Leonard, M
   Kendra, J
   Ko, JB
   Yoo, C
   Pradelles, R
   Johnson, S
   Purpura, M
   Jäger, R
   Sowinski, R
   Rasmussen, CJ
   Kreider, RB
AF Dickerson, Broderick
   Maury, Jonathan
   Jenkins, Victoria
   Nottingham, Kay
   Xing, Dante
   Gonzalez, Drew E.
   Leonard, Megan
   Kendra, Jacob
   Ko, Joungbo
   Yoo, Choongsung
   Pradelles, Remi
   Johnson, Sarah
   Purpura, Martin
   Jager, Ralf
   Sowinski, Ryan
   Rasmussen, Christopher J.
   Kreider, Richard B.
TI Effects of Supplementation with Microalgae Extract from Phaeodactylum
   tricornutum (Mi136) to Support Benefits from a Weight Management
   Intervention in Overweight Women
SO NUTRIENTS
LA English
DT Article
DE fucoxanthin; obesity; appetite; bone mineral content; bone density;
   aerobic capacity; inflammation; blood lipids; functional capacity;
   quality of life
ID DIET-INDUCED OBESITY; BODY-COMPOSITION; METABOLIC SYNDROME; OXIDATIVE
   STRESS; LIPID-METABOLISM; FUCOXANTHIN; SEAWEED; ANTIOBESITY; EXERCISE;
   INSULIN
AB Background: Microalgae like Phaeodactylum tricornutum (PT) contain the carotenoid, fucoxanthin, which has been purported to promote fat loss, lower blood lipids, and improve glucose management. This study examined whether dietary supplementation with microalgae extracts from PT containing 4.4 mg/d of fucoxanthin affects changes in body composition or health markers in overweight women during an exercise and diet intervention. Materials and Methods: A total of 37 females (28.6 +/- 7.9 years, 80.2 +/- 14.9 kg, 29.6 +/- 3.8 kg/m(2), 41.4 +/- 4.2% fat) fasted for 12 h, donated a fasting blood sample, completed health and mood state inventories, and undertook body composition, health, and exercise assessments. In a counterbalanced, randomized, and double-blind manner, participants ingested a placebo (PL), or microalgae extract of Phaeodactylum tricornutum standardized to 4.4 mg of fucoxanthin (FX) for 12 weeks while participating in a supervised exercise program that included resistance-training and walking (3 days/week) with encouragement to accumulate 10,000 steps/day on remaining days of the week. The diet intervention involved reducing energy intake by about -300 kcal/d (i.e., approximate to 1400-1600 kcals/d, 55% carbohydrate, 30% fat, 15% protein) to promote a -500 kcal/d energy deficit with exercise. Follow-up testing was performed at 6 and 12 weeks. A general linear model (GLM) with repeated measures statistical analysis was used to analyze group responses and changes from baseline with 95% confidence intervals. Results: Dietary supplementation with microalgae extract from PT containing fucoxanthin for 12 weeks did not promote additional weight loss or fat loss in overweight but otherwise healthy females initiating an exercise and diet intervention designed to promote modest weight loss. However, fucoxanthin supplementation preserved bone mass, increased bone density, and saw greater improvements in walking steps/day, resting heart rate, aerobic capacity, blood lipid profiles, adherence to diet goals, functional activity tolerance, and measures of quality of life. Consequently, there appears to be some benefit to supplementing microalgae extract from PT containing fucoxanthin during a diet and exercise program. Registered clinical trial #NCT04761406.
C1 [Dickerson, Broderick; Jenkins, Victoria; Nottingham, Kay; Xing, Dante; Gonzalez, Drew E.; Leonard, Megan; Kendra, Jacob; Ko, Joungbo; Yoo, Choongsung; Johnson, Sarah; Sowinski, Ryan; Rasmussen, Christopher J.; Kreider, Richard B.] Texas A&M Univ, Dept Kinesiol & Sports Management, Exercise & Sport Nutr Lab, College Stn, TX 77843 USA.
   [Maury, Jonathan; Pradelles, Remi] Res & Dev Dept, Microphyt, F-34670 Baillargues, France.
   [Purpura, Martin; Jager, Ralf] Increnovo LLC, Whitefish Bay, WI 53217 USA.
C3 Texas A&M University System; Texas A&M University College Station
RP Kreider, RB (corresponding author), Texas A&M Univ, Dept Kinesiol & Sports Management, Exercise & Sport Nutr Lab, College Stn, TX 77843 USA.
EM dickersobl5@email.tamu.edu; jonathan.maury@microphyt.eu;
   victoria.jenkins@tamu.edu; kirsten.nottingham@cpcmed.org;
   dantexing@tamu.edu; dg18@tamu.edu; meganleonard10@tamu.edu;
   jkendra@tamu.edu; joungboko10@tamu.edu; choongsungyoo@tamu.edu;
   remi.pradelles@microphyt.eu; sjohnson2216@tamu.edu;
   martin.purpura@increnovo.com; ralf.jaeger@increnovo.com;
   rjs370@tamu.edu; crasmussen@tamu.edu; rbkreider@tamu.edu
RI Rasmussen, Christopher/B-9478-2011; Kreider, Richard/AEE-5745-2022;
   Kreider, Richard/O-1804-2014
OI Kendra, Jacob/0009-0002-9940-8497; Gonzalez, Andrew
   Edward/0000-0002-7279-4968; Sowinski, Ryan/0000-0003-3885-4100; Kreider,
   Richard/0000-0002-3906-1658; Leonard, Megan/0000-0003-4209-3885;
   Jenkins, Victoria/0000-0002-2348-5114; Yoo,
   Choongsung/0000-0002-1112-336X; Dickerson,
   Broderick/0000-0002-9216-2941; MAURY, Jonathan/0009-0005-0370-8949
FU Microphyt (Baillargues, FRA)
FX We thank the participants, J.P. Bramhall who served as medical
   supervisor, Peter Murano who served as an external quality assurance
   monitor, and the students and staff who provided additional support
   including Elena Chavez, Jisun Chun, Jacob Broeckel, and Landry Estes.
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NR 114
TC 9
Z9 9
U1 6
U2 10
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD APR
PY 2024
VL 16
IS 7
AR 990
DI 10.3390/nu16070990
PG 24
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA NP4U2
UT WOS:001201650300001
PM 38613023
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Dehghani, F
   Hajhashemy, Z
   Keshteli, AH
   Yazdannik, A
   Falahi, E
   Saneei, P
   Esmaillzadeh, A
AF Dehghani, Farimah
   Hajhashemy, Zahra
   Keshteli, Ammar Hassanzadeh
   Yazdannik, Ahmadreza
   Falahi, Ebrahim
   Saneei, Parvane
   Esmaillzadeh, Ahmad
TI Nutrient patterns in relation to insulin resistance and endothelial
   dysfunction in Iranian women
SO SCIENTIFIC REPORTS
LA English
DT Article
ID SENSITIVITY CHECK INDEX; METABOLIC SYNDROME; CARDIOVASCULAR-DISEASE;
   OXIDATIVE STRESS; RISK-FACTORS; OLIVE OIL; DASH DIET; RED MEAT; OBESITY;
   MARKERS
AB Prior studies have mainly focused on the association of one specific nutrient with insulin resistance (IR) and endothelial dysfunction and limited studies have assessed the association with different nutrient patterns (NPs). We examined the association between various NPs and IR and endothelial dysfunction among Iranian women. This cross-sectional study was carried out on a sample of 368 female nurses. A 106-items food frequency questionnaire (FFQ) was applied for dietary assessments. Using factor analysis, the relationships between NPs and markers of insulin resistance (HOMA-IR, HOMA-beta, and QUICKY), and endothelial dysfunction (E-selectin, sICAM-1, and sVCAM-1) were assessed. Mean age and body mass index of participants were respectively 35.21 years and 24.04 kg/m2. Three major NPs were identified. NP1, named as "dairy, fruits, and vegetables" had high values of potassium, folate, vitamins A and C, magnesium, and beta carotene. No significant association was observed between this NP and insulin resistance or endothelial dysfunction indices. The second NP was full of chromium, selenium, copper, vitamin B6, monounsaturated fatty acid (MUFA), thiamin, vitamin D, and iron. Adherence to NP2 (named "legumes, nuts, and protein foods") was associated with lower values of insulin (6.8 +/- 1.1 versus 8.4 +/- 1.1, P = 0.01), homeostasis model assessment-Insulin resistance (HOMA-IR) (1.3 +/- 0.2 versus 1.7 +/- 0.2, P = 0.02), and vascular adhesion molecule 1 (VCAM-1) (444.2 +/- 27.9 versus 475.8 +/- 28.4, P = 0.03). However, adherence to the third NP, rich in saturated fatty acid (SFA), cholesterol, sodium, zinc, vitamin E, and B12, described as "animal fat and meat + vitamin E", was associated with higher amounts of homeostasis model assessment-beta (HOMA-beta) (531.3 +/- 176.2 versus 48.7 +/- 179.8, P = 0.03). In conclusion, following the NP2, correlated with higher intakes of chromium, selenium, copper, vitamin B6, MUFA and thiamin was associated with lower values of insulin, HOMA-IR, and sVCAM-1. Adherence to NP3, rich in SFA, cholesterol, vitamin E, vitamin B12, and zinc was associated with higher levels of HOMA-beta.
C1 [Dehghani, Farimah; Esmaillzadeh, Ahmad] Univ Tehran Med Sci, Sch Nutrit Sci & Dietet, Dept Community Nutr, POB 14155-6117, Tehran, Iran.
   [Hajhashemy, Zahra; Saneei, Parvane] Isfahan Univ Med Sci, Nutr & Food Secur Res Ctr, Sch Nutr & Food Sci, Dept Community Nutr, POB 81745-151, Esfahan, Iran.
   [Hajhashemy, Zahra] Isfahan Univ Med Sci, Students Res Comm, Esfahan, Iran.
   [Keshteli, Ammar Hassanzadeh] Univ Alberta, Dept Med, Edmonton, AB, Canada.
   [Yazdannik, Ahmadreza] Isfahan Univ Med Sci, Sch Nursing & Midwifery, Dept Crit Care Nursing, Esfahan, Iran.
   [Falahi, Ebrahim] Lorestan Univ Med Sci, Sch Hlth & Nutr, Dept Nutr, Khorramabad, Iran.
   [Esmaillzadeh, Ahmad] Univ Tehran Med Sci, Endocrinol & Metab Mol Cellular Sci Inst, Obes & Eating Habits Res Ctr, Tehran, Iran.
   [Esmaillzadeh, Ahmad] Univ Tehran Med Sci, Endocrinol & Metab Clin Sci Inst, Endocrinol & Metab Res Ctr, Tehran, Iran.
C3 Tehran University of Medical Sciences; Isfahan University of Medical
   Sciences; Isfahan University of Medical Sciences; University of Alberta;
   Isfahan University of Medical Sciences; Lorestan University of Medical
   Sciences; Tehran University of Medical Sciences; Tehran University of
   Medical Sciences
RP Esmaillzadeh, A (corresponding author), Univ Tehran Med Sci, Sch Nutrit Sci & Dietet, Dept Community Nutr, POB 14155-6117, Tehran, Iran.; Saneei, P (corresponding author), Isfahan Univ Med Sci, Nutr & Food Secur Res Ctr, Sch Nutr & Food Sci, Dept Community Nutr, POB 81745-151, Esfahan, Iran.; Esmaillzadeh, A (corresponding author), Univ Tehran Med Sci, Endocrinol & Metab Mol Cellular Sci Inst, Obes & Eating Habits Res Ctr, Tehran, Iran.; Esmaillzadeh, A (corresponding author), Univ Tehran Med Sci, Endocrinol & Metab Clin Sci Inst, Endocrinol & Metab Res Ctr, Tehran, Iran.
EM saneeip@yahoo.com; a.esmaillzadeh@gmail.com
RI Falahi, Ebrahim/D-7319-2017; Saneei, Parvane/T-5434-2019; Keshteli,
   Ammar/K-7473-2012; Esmaillzadeh, Ahmad/N-5704-2014
FU Tehran University of Medical Sciences, Tehran, Iran [9911323005]
FX The financial support for conception, design, data analysis and
   manuscript drafting comes from Tehran University of Medical Sciences,
   Tehran, Iran (9911323005).
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NR 64
TC 1
Z9 1
U1 1
U2 1
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD FEB 3
PY 2024
VL 14
IS 1
AR 2857
DI 10.1038/s41598-024-53263-1
PG 13
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA HG3S6
UT WOS:001158306200012
PM 38310135
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Bourebaba, L
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   Sikora, M
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   Mularczyk, M
   Al Naem, M
   Marycz, K
AF Bourebaba, Lynda
   Zyzak, Magdalena
   Sikora, Mateusz
   Serwotka-Suszczak, Anna
   Mularczyk, Malwina
   Al Naem, Mohamad
   Marycz, Krzysztof
TI Sex Hormone-Binding Globulin (SHBG) Maintains Proper Equine
   Adipose-Derived Stromal Cells (ASCs)' Metabolic Functions and Negatively
   Regulates their Basal Adipogenic Potential
SO STEM CELL REVIEWS AND REPORTS
LA English
DT Article
DE SHBG; ASCs; Knockdown; Apoptosis; Antiadipogenic; Mitochondrial dynamics
ID IMPAIRED APOPTOSIS; PROLIFERATION; EXPRESSION; GENES; GAMMA; BAX
AB Background Sex hormone binding globulin (SHBG) deteriorated expression has been recently strongly correlated to increased level of circulating pro-inflammatory cytokines and insulin resistance, which are typical manifestations of equine metabolic syndrome (EMS). Despite previous reports demonstrated the potential therapeutic application of SHBG for liver-related dysfunctions, whether SHBG might modulate equine adipose-derived stem/stromal cells (EqASCs) metabolic machinery remains unknown. Therefore, we evaluated for the first time the impact of SHBG protein on metabolic changes in ASCs isolated from healthy horses.Methods Beforehand, SHBG protein expression has been experimentally lowered using a predesigned siRNA in EqASCs to verify its metabolic implications and potential therapeutic value. Then, apoptosis profile, oxidative stress, mitochondrial network dynamics and basal adipogenic potential have been evaluated using various molecular and analytical techniques.Results The SHBG knockdown altered the proliferative and metabolic activity of EqASCs, while dampening basal apoptosis via Bax transcript suppression. Furthermore, the cells treated with siRNA were characterized by senescent phenotype, accumulation of reactive oxygen species (ROS), nitric oxide, as well as decreased mitochondrial potential that was shown by mitochondrial membrane depolarization and lower expression of key mitophagy factors: PINK, PARKIN and MFN. The addition of SHBG protein reversed the impaired and senescent phenotype of EMS-like cells that was proven by enhanced proliferative activity, reduced apoptosis resistance, lower ROS accumulation and greater mitochondrial dynamics, which is proposed to be related to a normalization of Bax expression. Crucially, SHBG silencing enhanced the expression of key pro-adipogenic effectors, while decreased the abundance of anti-adipogenic factors namely HIF1-a and FABP4. The addition of exogenous SHBG further depleted the expression of PPAR? and C/EBPa and restored the levels of FABP4 and HIF1-a evoking a strong inhibitory potential toward ASCs adipogenesis.Conclusion Herein, we provide for the first time the evidence that SHBG protein in importantly involved in various key metabolic pathways governing EqASCs functions, and more importantly we showed that SHBG negatively affect the basal adipogenic potential of tested ASCs through a FABP4-dependant pathway, and provide thus new insights for the development of potential anti-obesity therapeutic approach in both animals and humans.
C1 [Bourebaba, Lynda; Zyzak, Magdalena; Sikora, Mateusz; Serwotka-Suszczak, Anna; Mularczyk, Malwina; Marycz, Krzysztof] Wroclaw Univ Environm & Life Sci, Fac Biol & Anim Sci, Dept Expt Biol, Norwida 27B, PL-50375 Wroclaw, Poland.
   [Al Naem, Mohamad] Justus Liebig Univ, Fac Vet Med, Equine Clin Equine Surg, D-35392 Giessen, Germany.
   [Marycz, Krzysztof] Univ Calif Davis, Vet Inst Regenerat Cures, Sch Vet Med, Dept Vet Med & Epidemiol, Davis, CA 95616 USA.
C3 Wroclaw University of Environmental & Life Sciences; Justus Liebig
   University Giessen; University of California System; University of
   California Davis
RP Marycz, K (corresponding author), Wroclaw Univ Environm & Life Sci, Fac Biol & Anim Sci, Dept Expt Biol, Norwida 27B, PL-50375 Wroclaw, Poland.; Marycz, K (corresponding author), Univ Calif Davis, Vet Inst Regenerat Cures, Sch Vet Med, Dept Vet Med & Epidemiol, Davis, CA 95616 USA.
EM krzysztof.marycz@upwr.edu.pl
RI Bourebaba, Lynda/AAX-7613-2020; Serwotka-Suszczak, Anna/L-7188-2019;
   Marycz, Krzysztof/A-2249-2017; Zyzak, Magdalena/KCY-7464-2024
OI Zyzak, Magdalena/0000-0001-5960-9695
FU National Science Centre in Poland [2019/35/B/NZ7/03651]; Higher
   Education and Science
FX & nbsp;The work was supported by a research grant financed by the
   National Science Centre in Poland over the course of the realization of
   the project: "Exploring the role and therapeutic potential of sex
   hormone binding globulin (SHBG) in the course of insulin resistance,
   inflammation, lipotoxicity in adipose stem progenitor cells and
   adipo-cytes in equine metabolic syndrome (EMS) mares" (No
   2019/35/B/NZ7/03651). "Publication fees have been supported by the
   Leading Research Groups support project from the subsidy increased for
   the period 2020-2025 in the amount of 2% of the subsidy referred to Art.
   387 (3) of the Law of 20 July 2018 on Higher Education and Science,
   obtained in 2019".
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NR 57
TC 3
Z9 3
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 2629-3269
EI 2629-3277
J9 STEM CELL REV REP
JI Stem Cell Rev. Rep.
PD OCT
PY 2023
VL 19
IS 7
BP 2251
EP 2273
DI 10.1007/s12015-023-10580-8
EA JUL 2023
PG 23
WC Cell & Tissue Engineering; Cell Biology; Medicine, Research &
   Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Research & Experimental Medicine
GA U5AZ2
UT WOS:001025081400002
PM 37402098
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Zhao, ZY
   Ji, HX
   Zhao, YS
   Liu, ZY
   Sun, RT
   Li, YQ
   Ni, TS
AF Zhao, Ziyi
   Ji, Hongxiang
   Zhao, Yunsheng
   Liu, Zeyu
   Sun, Ruitao
   Li, Yuquan
   Ni, Tongshang
TI Effectiveness and safety of hydrogen inhalation as an adjunct treatment
   in Chinese type 2 diabetes patients: A retrospective, observational,
   double-arm, real-life clinical study
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Article
DE type 2 diabetes; observational study; hydrogen inhalation; glycemic
   control; real world study
ID MOLECULAR-HYDROGEN; RICH WATER; METABOLIC SYNDROME; CONSENSUS STATEMENT;
   OXIDATIVE STRESS; LIPID PROFILES; ANTIOXIDANT; ASSOCIATION; PREVALENCE;
   SALINE
AB AimTo analyze the effectiveness and safety of hydrogen inhalation (HI) therapy as an adjunct treatment in Chinese type 2 diabetes mellitus (T2DM) patients in a real-life clinical setting. MethodsThis observational, non-interventional, retrospective, double-arm, 6-month clinical study included T2DM patients receiving conventional anti-diabetes medication with or without HI initiation from 2018 to 2021. Patients were assigned to the HI group or non-HI group (control group) after 1:1 propensity score matching (PSM). The mean change in glycated hemoglobin (HbA1c) after 6 months in different groups was evaluated primarily. The secondary outcome was composed of the mean change of fasting plasma glucose (FPG), weight, lipid profile, and homeostasis model assessment. Logistics regression was performed to evaluate the likelihood of reaching different HbA1c levels after 6-month treatment between the groups. Adverse event (AE) was also evaluated in patients of both groups. ResultsIn total, 1088 patients were selected into the analysis. Compared to the control group, subjects in HI group maintained greater improvement in the level of HbA1c (-0.94% vs -0.46%), FPG (-22.7 mg/dL vs -11.7 mg/dL), total cholesterol (-12.9 mg/dL vs -4.4 mg/dL), HOMA-IR (-0.76 vs -0.17) and HOMA-beta (8.2% vs 1.98%) with all p< 0.001 post the treatment. Logistics regression revealed that the likelihood of reaching HbA1c< 7%, >= 7% to< 8% and > 1% reduction at the follow-up period was higher in the HI group, while patients in the control group were more likely to attain HbA1c >= 9%. Patients in HI group was observed a lower incidence of several AEs including hypoglycemia (2.0% vs 6.8%), vomiting (2.6% vs 7.4%), constipation (1.7% vs 4.4%) and giddiness (3.3% vs 6.3%) with significance in comparison to the control group. ConclusionHI as an adjunct therapy ameliorates glycemic control, lipid metabolism, insulin resistance and AE incidence of T2DM patients after 6-month treatment, presenting a noteworthy inspiration to existing clinical diabetic treatment.
C1 [Zhao, Ziyi; Liu, Zeyu; Sun, Ruitao] Qingdao Univ, Sch Clin Med, Dept Med, Qingdao, Peoples R China.
   [Ji, Hongxiang; Li, Yuquan] Shandong Univ Tradit Chinese Med, Coll Tradit Chinese Med, Jinan, Peoples R China.
   [Zhao, Yunsheng] Qingdao Hiser Hosp, Qingdao Hosp Tradit Chinese Med, Dept Endocrinol, Qingdao, Peoples R China.
   [Ni, Tongshang] Qingdao Univ, Ctr Integrated Tradit Chinese & Western Med, Dept Med, Qingdao, Peoples R China.
C3 Qingdao University; Shandong University of Traditional Chinese Medicine;
   Qingdao University
RP Ni, TS (corresponding author), Qingdao Univ, Ctr Integrated Tradit Chinese & Western Med, Dept Med, Qingdao, Peoples R China.
EM neetongshang@126.com
RI Zhao, Ziyi/GXH-2348-2022
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NR 61
TC 3
Z9 4
U1 0
U2 6
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD JAN 18
PY 2023
VL 13
AR 1114221
DI 10.3389/fendo.2022.1114221
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 8G0AW
UT WOS:000920016000001
PM 36743938
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Jiang, YW
   Sun, ZH
   Tong, WW
   Yang, K
   Guo, KQ
   Liu, G
   Pan, A
AF Jiang, Yi-Wen
   Sun, Zhong-Han
   Tong, Wen-Wei
   Yang, Kun
   Guo, Kun-Quan
   Liu, Gang
   Pan, An
TI Dietary Intake and Circulating Concentrations of Carotenoids and Risk of
   Type 2 Diabetes: A Dose-Response Meta-Analysis of Prospective
   Observational Studies
SO ADVANCES IN NUTRITION
LA English
DT Review
DE carotenoids; type 2 diabetes; prospective observational study;
   systematic review; meta-analysis
ID TOTAL ANTIOXIDANT CAPACITY; BETA-CAROTENE; CARDIOVASCULAR-DISEASE;
   OXIDATIVE STRESS; SUPPLEMENTATION; LYCOPENE; WOMEN; ASSOCIATION;
   METABOLISM; MELLITUS
AB Previous meta-analysis studies have indicated inverse associations between some carotenoids and risks of metabolic syndrome, cardiovascular disease, cancer, and all-cause mortality. However, the results for associations between carotenoids and type 2 diabetes (T2D) remain inconsistent and no systematic assessment has been done on this topic. We conducted a systematic review and meta-analysis to examine the associations of dietary intakes and circulating concentrations of carotenoids with risk of T2D. We searched PubMed and Ovid Embase from database inception to July 2020. Prospective observational studies of carotenoids and T2D risk were included. Random-effects models were used to summarize the RRs and 95% CIs. Thirteen publications were included. Dietary intake of beta-carotene was inversely associated with the risk of T2D, and the pooled RR comparing the highest with the lowest categories was 0.78 (95% CI: 0.70, 0.87; I-2 = 13.7%; n = 6); inverse associations were also found for total carotenoids (n = 2), alpha-carotene (n = 4), and lutein/zeaxanthin (n = 4), with pooled RRs ranging from 0.80 to 0.91, whereas no significant associations were observed for beta-cryptoxanthin and lycopene. Circulating concentration of beta-carotene was associated with a lower risk of T2D, and the pooled RR comparing extreme categories was 0.60 (95% CI: 0.46, 0.78; I-2 = 56.2%; n = 7); inverse associations were also found for total carotenoids (n = 3), lycopene (n = 4), and lutein (n = 2), with pooled RRs ranging from 0.63 to 0.85, whereas no significant association was found for circulating concentrations of alpha-carotene and zeaxanthin when comparing extreme categories. Dose-response analysis indicated that nonlinear relations were observed for circulating concentrations of alpha-carotene, beta-carotene, lutein, and total carotenoids (all P-nonlinearity < 0.05), but not for other carotenoids or dietary exposures. In conclusion, higher dietary intakes and circulating concentrations of total carotenoids, especially beta-carotene, were associated with a lower risk of T2D. More studies are needed to confirm the causality and explore the role of foods rich in carotenoids in prevention of T2D.
C1 [Jiang, Yi-Wen; Sun, Zhong-Han; Pan, An] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Dept Epidemiol & Biostat, Wuhan, Hubei, Peoples R China.
   [Jiang, Yi-Wen; Sun, Zhong-Han; Pan, An] Huazhong Univ Sci & Technol, State Key Lab Environm Hlth Incubating, Key Lab Environm & Hlth, Minist Educ,Sch Publ Hlth,Tongji Med Coll, Wuhan, Hubei, Peoples R China.
   [Jiang, Yi-Wen; Sun, Zhong-Han; Pan, An] Huazhong Univ Sci & Technol, State Key Lab Environm Hlth Incubating, Minist Environm Protect, Sch Publ Hlth,Tongji Med Coll, Wuhan, Hubei, Peoples R China.
   [Sun, Zhong-Han] Fudan Univ, Sch Life Sci, Human Phenome Inst, Dept Anthropol & Human Genet, Shanghai, Peoples R China.
   [Tong, Wen-Wei; Yang, Kun; Guo, Kun-Quan] Hubei Univ Med, Affiliated Dongfeng Hosp, Dept Endocrinol, Shiyan, Hubei, Peoples R China.
   [Liu, Gang] Huazhong Univ Sci & Technol, Hubei Key Lab Food Nutr & Safety, Dept Nutr & Food Hyg, Sch Publ Hlth,Tongji Med Coll,Minist Educ,Key Lab, Wuhan, Hubei, Peoples R China.
   [Pan, An] Chinese Acad Sci, Univ Chinese Acad Sci, Hangzhou Inst Adv Study, Key Lab Syst Biol, Hangzhou, Zhejiang, Peoples R China.
C3 Huazhong University of Science & Technology; Huazhong University of
   Science & Technology; Ministry of Education - China; Huazhong University
   of Science & Technology; Fudan University; Hubei University of Medicine;
   Huazhong University of Science & Technology; Ministry of Education -
   China; Chinese Academy of Sciences; University of Chinese Academy of
   Sciences, CAS
RP Pan, A (corresponding author), Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Dept Epidemiol & Biostat, Wuhan, Hubei, Peoples R China.; Pan, A (corresponding author), Huazhong Univ Sci & Technol, State Key Lab Environm Hlth Incubating, Key Lab Environm & Hlth, Minist Educ,Sch Publ Hlth,Tongji Med Coll, Wuhan, Hubei, Peoples R China.; Pan, A (corresponding author), Huazhong Univ Sci & Technol, State Key Lab Environm Hlth Incubating, Minist Environm Protect, Sch Publ Hlth,Tongji Med Coll, Wuhan, Hubei, Peoples R China.; Liu, G (corresponding author), Huazhong Univ Sci & Technol, Hubei Key Lab Food Nutr & Safety, Dept Nutr & Food Hyg, Sch Publ Hlth,Tongji Med Coll,Minist Educ,Key Lab, Wuhan, Hubei, Peoples R China.; Pan, A (corresponding author), Chinese Acad Sci, Univ Chinese Acad Sci, Hangzhou Inst Adv Study, Key Lab Syst Biol, Hangzhou, Zhejiang, Peoples R China.
EM liugang026@hust.edu.cn; panan@hust.edu.cn
RI Liu, Gang/H-6420-2019; Sun, Zhonghan/HKD-8761-2023; Pan, An/C-5572-2011
OI Sun, Zhonghan/0000-0003-4171-9794; Pan, An/0000-0002-1089-7945; Liu,
   Gang/0000-0002-1430-3016
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NR 57
TC 46
Z9 46
U1 2
U2 20
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 2161-8313
EI 2156-5376
J9 ADV NUTR
JI Adv. Nutr.
PD SEP
PY 2021
VL 12
IS 5
BP 1723
EP 1733
DI 10.1093/advances/nmab048
EA MAY 2021
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA WE1VW
UT WOS:000705416200010
PM 33979433
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Pitter, G
   Jeddi, MZ
   Barbieri, G
   Gion, M
   Fabricio, ASC
   Daprà, F
   Russo, F
   Fletcher, T
   Canova, C
AF Pitter, Gisella
   Zare Jeddi, Maryam
   Barbieri, Giulia
   Gion, Massimo
   Fabricio, Aline S. C.
   Dapra, Francesca
   Russo, Francesca
   Fletcher, Tony
   Canova, Cristina
TI Perfluoroalkyl substances are associated with elevated blood pressure
   and hypertension in highly exposed young adults
SO ENVIRONMENTAL HEALTH
LA English
DT Article
DE Perfluoroalkyl substances; Blood pressure; Hypertension; Epidemiology;
   Cross-sectional study; Community exposure
ID PERFLUOROOCTANOIC ACID EXPOSURE; OXIDATIVE STRESS; PERFLUORINATED
   COMPOUNDS; METABOLIC SYNDROME; SERUM ISOMERS; LIPID-LEVELS; PFOA; RISK;
   CHEMICALS; MORTALITY
AB Background Residents in a large area of North-Eastern Italy were exposed to perfluoroalkyl substances (PFAS) via drinking water. Studies on the association between PFAS and blood pressure levels are limited, and results are inconsistent. Using cross-sectional data from the Regional health surveillance program, we aimed to quantify the associations between PFAS serum concentrations and blood pressure and hypertension prevalence. Methods The study comprised 16,224 individuals aged 20-39 years. Pregnant women (n = 327), or individuals with missing information on the selected covariates (n = 111) were excluded, leaving 15,786 subjects for the analyses. Hypertension was defined as any self-reported diagnosis, use of antihypertensive drugs, or elevated systolic blood pressure (SBP >= 140 mmHg)/diastolic blood pressure (DBP >= 90 mmHg). Generalized additive models were used to investigate the relation between perfluorooctanoic acid (PFOA), perfluorooctane sulfonic acid (PFOS), perfluorohexane sulfonic acid (PFHxS), and perfluorononanoic acid (PFNA)) natural log (ln) transformed and by decile, and SBP, DBP, hypertension, adjusted for potential confounders. Results Both SBP and DBP increased significantly with an increase in the ln-transformed serum PFAS concentrations in a monotonic way. The predicted increase in SBP and DBP were 1.54 mmHg (95%CI 0.61-2.47), 1.60 mmHg (95%CI 0.92-2.27) from lowest to highest decile of PFOA. The associations were stronger for SBP in men and for DBP in women. One unit increase in each In-transformed PFAS was positively associated with an increased odd of hypertension in men: PFOA OR = 1.06 (1.01-1.11), PFOS OR = 1.13 (1.03-1.23), PFHxS OR = 1.08 (1.02-1.15), PFNA OR = 1.20 (1.02-1.40). Conclusions Our findings suggest that serum PFAS concentrations were associated with increased systolic and diastolic blood pressure in a large highly exposed young adult population.Although the magnitude of the observed effect was relatively small, if confirmed it would be of public health relevance since even small increases in blood pressure levels at the population level may be associated to a raised risk of adverse outcomes such as cardiovascular disease and target organ damage.
C1 [Pitter, Gisella] Azienda Zero Veneto Reg, Screening & Hlth Impact Assessment Unit, Padua, Italy.
   [Zare Jeddi, Maryam; Barbieri, Giulia; Canova, Cristina] Dept Cardiothoracovac Sci & Publ Hlth, Unit Biostat Epidemiol & Publ Hlth, Via Loredan 18, I-35131 Padua, Italy.
   [Gion, Massimo; Fabricio, Aline S. C.] Azienda ULSS 3 Serenissima, Dept Clin Pathol, Reg Ctr Biomarkers, Venice, Italy.
   [Dapra, Francesca] Reg Agcy Environm Prevent & Protect Veneto Reg, Lab Dept, Venice, Italy.
   [Russo, Francesca] Directorate Prevent Food Safety & Vet Publ Hlth V, Venice, Italy.
   [Fletcher, Tony] London Sch Hyg & Trop Med, London, England.
C3 ULSS 3 Serenissima; Ospedale SS Giovanni Paolo Venezia; University of
   London; London School of Hygiene & Tropical Medicine
RP Canova, C (corresponding author), Dept Cardiothoracovac Sci & Publ Hlth, Unit Biostat Epidemiol & Publ Hlth, Via Loredan 18, I-35131 Padua, Italy.
EM cristina.canova@unipd.it
RI Pitter, Gisella/HZJ-0124-2023; Zare Jeddi, Maryam/KXQ-7738-2024;
   Fabricio, Aline/ISV-5265-2023; Russo, Francesca/AAY-7245-2020; Fletcher,
   Tony/D-2394-2011
OI Zare Jeddi, Maryam/0000-0002-9505-812X; Fletcher,
   Tony/0000-0003-3385-200X; Fabricio, Aline/0000-0003-0153-8809
FU CONVENZIONE CORIS PER REALIZZAZIONE PROGETTI DI RICERCA INNOVATIVI SUI
   PFAS 2017-18 [CANO_ALFREVE18_01]; RIS/REGIONE VENETO (IT)
FX RIS/REGIONE VENETO (IT) supported this research with a grant to Cristina
   Canova. Award Number: CANO_ALFREVE18_01 (CONVENZIONE CORIS PER
   REALIZZAZIONE PROGETTI DI RICERCA INNOVATIVI SUI PFAS 2017-18). The
   funder had no role in study design, data collection and analysis,
   decision to publish, or preparation of the manuscript.
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NR 48
TC 56
Z9 62
U1 2
U2 44
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1476-069X
J9 ENVIRON HEALTH-GLOB
JI Environ. Health
PD SEP 21
PY 2020
VL 19
IS 1
AR 102
DI 10.1186/s12940-020-00656-0
PG 11
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA NV4OQ
UT WOS:000574303500001
PM 32958007
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Zhang, KX
   Rao, FW
   Wang, L
   Rana, BK
   Ghosh, S
   Mahata, M
   Salem, RM
   Rodriguez-Flores, JL
   Fung, MM
   Waalen, J
   Tayo, B
   Taupenot, L
   Mahata, SK
   O'Connor, DT
AF Zhang, Kuixing
   Rao, Fangwen
   Wang, Lei
   Rana, Brinda K.
   Ghosh, Sajalendu
   Mahata, Manjula
   Salem, Rany M.
   Rodriguez-Flores, Juan L.
   Fung, Maple M.
   Waalen, Jill
   Tayo, Bamidele
   Taupenot, Laurent
   Mahata, Sushil K.
   O'Connor, Daniel T.
TI Common Functional Genetic Variants in Catecholamine Storage Vesicle
   Protein Promoter Motifs Interact to Trigger Systemic Hypertension
SO JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
LA English
DT Article
DE hypertension; catecholamine; chromaffin; chromogranin; exocytosis
ID AUTONOMIC NERVOUS-SYSTEM; CHROMOGRANIN-B; BLOOD-PRESSURE; LINKAGE
   DISEQUILIBRIUM; SEX DETERMINATION; SYMPATHOCHROMAFFIN SECRETION;
   METABOLIC SYNDROME; SECRETOGRANIN-II; C-FOS; ASSOCIATION
AB Objectives
   The purpose of this study is to understand whether naturally occurring genetic variation in the promoter of chromogranin B (CHGB), a major constituent of catecholamine storage vesicles, is functional and confers risk for cardiovascular disease.
   Background
   CHGB plays a necessary (catalytic) role in catecholamine storage vesicle biogenesis. Previously, we found that genetic variation at CHGB influenced autonomic function, with association maximal toward the 5' region. Methods Here we explored transcriptional mechanisms of such effects, characterizing 2 common variants in the proximal promoter, A-296C and A-261T, using transfection/cotransfection, electrophoretic mobility shift assay (EMSA), and chromatin immunoprecipitation (ChIP). We then tested the effects of promoter variation on cardiovascular traits.
   Results
   The A-296C disrupted a c-FOS motif, exhibiting differential mobility shifting to chromaffin cell nuclear proteins during EMSA, binding of endogenous c-FOS on ChIP, and differential response to exogenous c-FOS. The A-261T disrupted motifs for SRY and YY1, with similar consequences for EMSA, endogenous factor binding, and responses to exogenous factors. The 2-SNP CHGB promoter haplotypes had a profound (p = 3.16E-20) effect on blood pressure (BP) in the European ancestry population, with a rank order of CT <AA <<CA<AT on both systolic blood pressure (SBP) and diastolic blood pressure (DBP), accounting for approximate to 2.3% to approximate to 3.4% of SBP/DBP variance; the haplotype effects on BP in vivo paralleled those on promoter activity in cella. Site-by-site interactions at A-296C and A-261T yielded highly nonadditive effects on SBP/DBP. The CHGB haplotype effects on BP were also noted in an independent (African ancestry) sample. In normotensive twins, parallel effects were noted for a pre-hypertensive phenotype, BP response to environmental stress.
   Conclusions
   The common CHGB promoter variants A-296C and A-261T, and their consequent haplotypes, alter binding of specific transcription factors to influence gene expression in cella as well as BP in vivo. Such variation contributes substantially to risk for human hypertension. Involvement of the sex-specific factor SRY suggests a novel mechanism for development of sexual dimorphism in BP. (J Am Coll Cardiol 2010; 55: 1463-75) (C) 2010 by the American College of Cardiology Foundation
C1 [Zhang, Kuixing; Rao, Fangwen; Wang, Lei; Ghosh, Sajalendu; Mahata, Manjula; Salem, Rany M.; Rodriguez-Flores, Juan L.; Fung, Maple M.; Taupenot, Laurent; Mahata, Sushil K.; O'Connor, Daniel T.] Univ Calif San Diego, Dept Med, San Diego, CA 92103 USA.
   [O'Connor, Daniel T.] Univ Calif San Diego, Dept Pharmacol, San Diego, CA 92103 USA.
   [Rana, Brinda K.] Univ Calif San Diego, Dept Psychiat, San Diego, CA 92103 USA.
   [O'Connor, Daniel T.] Univ Calif San Diego, Inst Genom Med, San Diego, CA 92103 USA.
   [Mahata, Sushil K.; O'Connor, Daniel T.] VA San Diego Healthcare Syst, La Jolla, CA USA.
   [Waalen, Jill] Scripps Res Inst, Dept Mol & Expt Med, La Jolla, CA 92037 USA.
   [Tayo, Bamidele] Loyola Univ, Sch Med, Dept Prevent Med, Maywood, IL 60153 USA.
C3 University of California System; University of California San Diego;
   University of California System; University of California San Diego;
   University of California System; University of California San Diego;
   University of California System; University of California San Diego; US
   Department of Veterans Affairs; Veterans Health Administration (VHA); VA
   San Diego Healthcare System; Scripps Research Institute; Loyola
   University Chicago
RP O'Connor, DT (corresponding author), UCSD Sch Med, Dept Med, 9500 Gilman Dr, La Jolla, CA 92093 USA.
EM smahata@ucsd.edu; doconnor@ucsd.edu
RI Mahata, Sushil/AAF-8781-2021; Rodriguez-Flores, Juan/AAJ-7565-2020;
   Rodriguez-Flores, Juan L/M-4899-2013
OI Taupenot, Laurent/0000-0003-2316-3825; Salem, Rany/0000-0001-8816-6862;
   Rodriguez-Flores, Juan L/0000-0002-0394-8062
FU Department of Veterans Affairs, National Institutes of Health (NIH);
   NIH/National Heart, Lung, and Blood Institute [HL58120]; NIH/National
   Center on Minority Health and Health Disparities-sponsored [MD000220];
   EXPORT/Comprehensive Research Center in Health Disparities Minority
   Health Center; NIH/National Center for Research Resources-sponsored
   [RR00827]
FX This study is supported by the Department of Veterans Affairs, National
   Institutes of Health (NIH), the NIH/National Heart, Lung, and Blood
   Institute (HL58120), the NIH/National Center on Minority Health and
   Health Disparities-sponsored (MD000220) EXPORT/Comprehensive Research
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NR 61
TC 17
Z9 18
U1 0
U2 3
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0735-1097
EI 1558-3597
J9 J AM COLL CARDIOL
JI J. Am. Coll. Cardiol.
PD APR 6
PY 2010
VL 55
IS 14
BP 1463
EP 1475
DI 10.1016/j.jacc.2009.11.064
PG 13
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 583AV
UT WOS:000276644500010
PM 20359597
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Badi, FM
   Bathaie, SZ
   Borazjani, F
   Hosseini, SA
   Sheikhi, MA
   Islam, SMS
   Angali, KA
   Sadeghi, MT
   Rahimi, P
AF Moeini Badi, Faezeh
   Bathaie, S. Zahra
   Borazjani, Fatemeh
   Hosseini, Seyed Ahmad
   Sheikhi, Mohammad Ali
   Shariful Islam, Sheikh Mohammed
   Ahmadi Angali, Kambiz
   Taban Sadeghi, Mohammadreza
   Rahimi, Parisa
TI The effect of crocetin (a saffron carotenoid) supplementation on
   antioxidant and inflammatory indexes and serum leptin concentration in
   patients with coronary artery disease
SO FOOD & FUNCTION
LA English
DT Article
ID C-REACTIVE PROTEIN; CROCUS-SATIVUS L.; DOUBLE-BLIND; INDUCED
   ATHEROSCLEROSIS; METABOLIC SYNDROME; AQUEOUS EXTRACT; TRIPLE-BLIND;
   INSULIN; IRAN; SENSITIVITY
AB Background: Coronary artery disease (CAD) is a common heart disease characterized by plaque buildup in the coronary arteries. Saffron, which is rich in active compounds, has strong antioxidant properties that help reduce free radicals and plasma malondialdehyde (MDA) levels. This study aimed to evaluate the effects of crocetin supplementation on antioxidant and inflammatory markers, as well as serum leptin levels, in CAD patients. Methods: In this double-blind, placebo-controlled trial conducted in Ahvaz, Iran, 50 clinically diagnosed CAD patients, including men and women aged 40-65, were randomly assigned to two parallel groups to receive either one tablet of 10 mg crocetin (n = 25) or one placebo (n = 25) daily for eight weeks. The primary outcome was high-sensitivity C-reactive protein (hs-CRP) levels, and the secondary outcomes included the activities of superoxide dismutase (SOD) and catalase (CAT), malondialdehyde (MDA) levels, the atherogenic index of plasma (AIP), leptin levels, anthropometric measurements, and body composition. Both groups followed similar dietary and exercise regimens. Results: We found no significant differences between the intervention and placebo groups regarding C-reactive protein (CRP) levels, as indicated by ANCOVA (P = 0.695). Similarly, ANCOVA results for leptin (P = 0.854), superoxide dismutase (SOD) (P = 0.520), malondialdehyde (MDA) (P = 0.178), and the atherogenic index of plasma (AIP) (P = 0.409) also did not show significant differences. However, a significant result was observed for catalase (CAT) (P = 0.008). The comparison of mean differences within the intervention and placebo groups showed clinical improvements for several measurements. Importantly, hs-CRP levels were -119.62 in the intervention group compared to -156.91 in the placebo group. Other mean differences included SOD (41.72 vs. -7.33), MDA (-0.99 vs. -0.16), AIP (-0.13 vs. 0.04), leptin (-1.86 vs. -0.09), systolic blood pressure (SBP) (-0.25 vs. 0.13), and diastolic blood pressure (DBP) (-0.24 vs. -0.01). Conclusions: Crocetin supplementation significantly improved inflammation, oxidative stress status, and leptin levels in CAD patients. Although further studies are needed to confirm these results in a larger population, crocetin administration may be recommended to prevent CAD.
C1 [Moeini Badi, Faezeh] Ahvaz Jundishapur Univ Med Sci, Clin Sci Res Inst, Nutr & Metab Dis Res Ctr, Ahvaz, Iran.
   [Bathaie, S. Zahra] Tarbiat Modares Univ, Fac Med Sci, Dept Clin Biochem, Tehran, Iran.
   [Bathaie, S. Zahra] Tarbiat Modares Univ, Inst Nat Prod & Med Plants INPMP, Tehran, Iran.
   [Borazjani, Fatemeh; Hosseini, Seyed Ahmad] Ahvaz Jundishapur Univ Med Sci, Clin Sci Res Inst, Nutr & Metab Dis Res Ctr, Ahvaz, Iran.
   [Shariful Islam, Sheikh Mohammed] Deakin Univ, Inst Phys Act & Nutr, Melbourne, Vic, Australia.
   [Borazjani, Fatemeh; Hosseini, Seyed Ahmad] Ahvaz Jundishapur Univ Med Sci, Sch Allied Med Sci, Dept Nutr, Ahvaz, Iran.
   [Sheikhi, Mohammad Ali] Ahvaz Jundishapur Univ Med Sci, Golestan Hosp, Atherosclerosis Res Ctr, Dept Cardiac Surg, Ahvaz, Iran.
   [Ahmadi Angali, Kambiz] Ahvaz Jundishapur Univ Med Sci, Sch Hlth Sci, Dept Biostat, Ahvaz, Iran.
   [Ahmadi Angali, Kambiz] Ahvaz Jundishapur Univ Med Sci, Social Determinant Hlth Res Ctr, Ahvaz, Iran.
C3 Ahvaz Jundishapur University of Medical Sciences (AJUMS); Tarbiat
   Modares University; Tarbiat Modares University; Ahvaz Jundishapur
   University of Medical Sciences (AJUMS); Deakin University; Ahvaz
   Jundishapur University of Medical Sciences (AJUMS); Ahvaz Jundishapur
   University of Medical Sciences (AJUMS); Ahvaz Jundishapur University of
   Medical Sciences (AJUMS); Ahvaz Jundishapur University of Medical
   Sciences (AJUMS)
RP Borazjani, F (corresponding author), Ahvaz Jundishapur Univ Med Sci, Clin Sci Res Inst, Nutr & Metab Dis Res Ctr, Ahvaz, Iran.; Borazjani, F (corresponding author), Ahvaz Jundishapur Univ Med Sci, Sch Allied Med Sci, Dept Nutr, Ahvaz, Iran.
EM moeinibadifaezeh@gmail.com; bathai_z@modares.ac.ir;
   borazjani-f@ajums.ac.ir; seyedahmadhosseini@yahoo.com;
   mohammadalisheikhi2016@gmail.com; drsislam@gmail.com;
   Iran.kzfir4@gmail.com; m_r_taban@yahoo.com; prs.rahimi@gmail.com
RI Hosseini, Seyed/V-3114-2017; Bathaie, S.Zahra/D-4165-2009; borazjani,
   fatemeh/I-9264-2018; Sheikhi, Mohammad/AAB-2825-2020
FU Ahvaz Jundishapur University of Medical Sciences [IR.AJUMS.REC.1402.024,
   NRC-0201]; Research Deputy of Ahvaz Jundishapur University of Medical
   Sciences and Nutrition and Metabolic Diseases Research Center, Clinical
   Sciences Research Institute, Ahvaz Jundishapur University of Medical
   Sciences, Ahvaz, Iran; Nutrition and Metabolic Diseases Research Center
   [IR.AJUMS.REC.1402.024]; Clinical Sciences Research Institute, Ahvaz
   Jundishapur University of Medical Sciences
FX This research was supported by the Research Deputy of Ahvaz Jundishapur
   University of Medical Sciences and Nutrition and Metabolic Diseases
   Research Center, Clinical Sciences Research Institute, Ahvaz Jundishapur
   University of Medical Sciences, Ahvaz, Iran (Ethic number:
   IR.AJUMS.REC.1402.024). The present study is based on data from the MSc
   thesis of Faezeh Moeini Badi (Project no. NRC-0201). We are grateful to
   the Research Deputy, the Nutrition and Metabolic Diseases Research
   Center, and the Clinical Sciences Research Institute, Ahvaz Jundishapur
   University of Medical Sciences, for approving this research project
   (IR.AJUMS.REC.1402.024), and special thanks are also extended to the
   patients who participated in this study.
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NR 60
TC 0
Z9 0
U1 0
U2 0
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PD JUN 3
PY 2025
VL 16
IS 11
BP 4604
EP 4614
DI 10.1039/d4fo03396e
EA MAY 2025
PG 11
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA 3HW3O
UT WOS:001492443400001
PM 40400479
DA 2025-06-11
ER

PT J
AU Diaf, M
   Khaled, MB
AF Diaf, Mustapha
   Khaled, Meghit Boumediene
TI Associations Between Dietary Antioxidant Intake and Markers of
   Atherosclerosis in Middle-Aged Women From North-Western Algeria
SO FRONTIERS IN NUTRITION
LA English
DT Article
DE atherosclerosis; dietary antioxidant; type 2 diabetes; middle-aged
   women; Algeria
ID CORONARY-HEART-DISEASE; APOLIPOPROTEIN-A-I; CARDIOVASCULAR-DISEASE;
   METABOLIC SYNDROME; OXIDATIVE STRESS; MYOCARDIAL-INFARCTION;
   RISK-FACTORS; RECOMMENDATIONS; INFLAMMATION; RATIOS
AB Background: The role of several dietary antioxidants in preventing the development and the progression of atherosclerosis has recently aroused considerable interest. Although they are not yet conclusive, most of the existing suggestions support this hypothesis.
   Objective: The aim of the present work was to investigate the intake of dietary antioxidant nutrients in relation to atherogenic indices in a group of Algerian middle aged women with and without type 2 diabetes.
   Methods: A cross-sectional study was conducted on a group of middle-aged women from the north western region of Algeria. Anthropometric and biochemical parameters were measured. Dietary intake was assessed using a validated 3-days food record. Atherogenic indices -total cholesterol-to-high-density lipoprotein cholesterol ratio (TC/HDL) and apolipoprotein (apo) B-to-apo A1 ratio, were calculated. Associations between antioxidants dietary intake and atherogenic indices were examined using logistic regressions.
   Results: 95 women with type 2 diabetes were compared to 93 non-diabetic ones. Statistical differences (p < 0.05) were revealed for body weight, height, body mass index (BMI), glycosylated hemoglobin (HbA1c) and total cholesterol levels. Furthermore, significant differences were noted for vitamin C, E and copper dietary intakes. The TC/HDL ratio was significantly associated to the highest quartiles of vitamin C in all patients; 3.519[2.405-4.408], p = 0.009 and in non-diabetic women; 3.984[1.775-7.412], p = 0.020, respectively. The odd ratios of vitamin E intakes were about 2.425[2.017-5.715], p = 0.012 in all patients and 1.843[1.877-2.731], p = 0.019 in non-diabetic group, respectively. However, the Apo B/Apo A1 ratio was more correlated to the highest quartiles of zinc and copper in non-diabetic group; OR = 0.059[0.006-0.572], p = 0.015 and 0.192[0.048-0.766], p = 0.019, respectively.
   Conclusion: The estimated risk of atherosclerosis measured through the TC/HDL ratio was correlated to vitamins antioxidant intake, while the probable risk assessed by the Apo B/Apo A1 ratio was more associated to the mineral profile.
C1 [Diaf, Mustapha; Khaled, Meghit Boumediene] Djillali Liabes Univ Sidi Bel Abbes, Fac Nat & Life Sci, Dept Biol, Sidi Bel Abbes, Algeria.
C3 University Djillali Liabes Sidi Bel Abbes
RP Khaled, MB (corresponding author), Djillali Liabes Univ Sidi Bel Abbes, Fac Nat & Life Sci, Dept Biol, Sidi Bel Abbes, Algeria.
EM khaled@khaledmb.co.uk
RI Khaled, Meghit Boumediene/C-4834-2014; DIAF, Mustapha/Q-2703-2018;
   Khaled, Meghit Boumediene/G-3945-2011
OI DIAF, Mustapha/0000-0001-6065-6659; Khaled, Meghit
   Boumediene/0000-0001-5281-2498
CR [Anonymous], 2005, WHO STEPWISE APPR CH
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NR 41
TC 8
Z9 8
U1 0
U2 3
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD APR 24
PY 2018
VL 5
AR 29
DI 10.3389/fnut.2018.00029
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA GF1BM
UT WOS:000431666600001
PM 29740584
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Hamana, T
   Sekimoto, T
   Finn, AV
   Virmani, R
AF Hamana, Tomoyo
   Sekimoto, Teruo
   Finn, Aloke V.
   Virmani, Renu
TI Age Differences in Aortic Stenosis
SO REVIEWS IN CARDIOVASCULAR MEDICINE
LA English
DT Review
DE aortic stenosis; calcific aortic valve disease; bioprosthetic valve
   failure
ID CORONARY-ARTERY-DISEASE; RHEUMATIC HEART-DISEASE;
   LOW-DENSITY-LIPOPROTEIN; KAPPA-B LIGAND; VALVE-REPLACEMENT; CELLULAR
   MECHANISMS; RECEPTOR ACTIVATOR; ADAPTIVE IMMUNITY; ANGIOTENSIN-II;
   LONG-TERM
AB Aortic stenosis (AS) is a significant and growing concern, with a prevalence of 2-3% in individuals aged over 65 years. Moreover, with an aging global population, the prevalence is anticipated to double by 2050. Indeed, AS can arise from various etiologies, including calcific trileaflets, congenital valve abnormalities (e.g., bicuspid and unicuspid valves), and post-rheumatic, whereby each has a distinct influence that shapes the onset and progression of the disease. The normal aortic valve has a trilaminar structure comprising the fibrosa, spongiosa, and ventricularis, which work together to maintain its function. In calcific AS, the disease begins with early calcification starting in high mechanical stress areas of the valve and progresses slowly over decades, eventually leading to extensive calcification resulting in impaired valve function. This process involves mechanisms similar to atherosclerosis, including lipid deposition, chronic inflammation, and mineralization. The progression of calcific AS is strongly associated with aging, with additional risk factors including male gender, smoking, dyslipidemia, and metabolic syndrome exacerbating the condition. Conversely, congenital forms of AS, such as bicuspid and unicuspid aortic valves, result in an earlier disease onset, typically 10-20 years earlier than that observed in patients with a normal tricuspid aortic valve. Rheumatic AS, although less common in developed countries due to effective antibiotic treatments, also exhibits age-related characteristics, with an earlier onset in individuals who experienced rheumatic fever in their youth. The only curative therapies currently available are surgical and transcatheter aortic valve replacement (TAVR). However, these options are sometimes too invasive for older patients; thus, management of AS, particularly in older patients, requires a comprehensive approach that considers age, disease severity, comorbidities, frailty, and each patient's individual needs. Although the valves used in TAVR demonstrate promising midterm durability, long-term data are still required, especially when used in younger individuals, usually with low surgical risk. Moreover, understanding the causes and mechanisms of structural valve deterioration is crucial for appropriate treatment selections, including valve selection and pharmacological therapy, since this knowledge is essential for optimizing the lifelong management of AS.
C1 [Hamana, Tomoyo; Sekimoto, Teruo; Finn, Aloke V.; Virmani, Renu] CVPath Inst Inc, Gaithersburg, MD 20878 USA.
   [Finn, Aloke V.] Univ Maryland, Sch Med, Baltimore, MD 21201 USA.
C3 CVPath Institute; University System of Maryland; University of Maryland
   Baltimore
RP Virmani, R (corresponding author), CVPath Inst Inc, Gaithersburg, MD 20878 USA.
EM rvirmani@cvpath.org
RI Virmani, Renu/ADN-4400-2022
OI Virmani, Renu/0000-0003-1879-0015
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NR 124
TC 0
Z9 0
U1 0
U2 0
PU IMR PRESS
PI ROBINSON
PA 112 ROBINSON RD, ROBINSON, SINGAPORE
SN 1530-6550
EI 2153-8174
J9 REV CARDIOVASC MED
JI Rev. Cardiovasc. Med.
PD APR 17
PY 2025
VL 26
IS 4
AR 28185
DI 10.31083/RCM28185
PG 18
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 2CD3Q
UT WOS:001479137400004
PM 40351685
DA 2025-06-11
ER

PT J
AU Jovanovski, E
   Marques, ADR
   Li, DD
   Ho, HVT
   Mejia, SB
   Sievenpiper, JL
   Zurbau, A
   Komishon, A
   Duvnjak, L
   Bazotte, RB
   Vuksan, V
AF Jovanovski, Elena
   Ruiz Marques, Any de Castro
   Li, Dandan
   Ho, Hoang V. T.
   Mejia, Sonia Blanco
   Sievenpiper, John L.
   Zurbau, Andreea
   Komishon, Allison
   Duvnjak, Lea
   Bazotte, Roberto B.
   Vuksan, Vladimir
TI Effect of high-carbohydrate or high-monounsaturated fatty acid diets on
   blood pressure: a systematic review and meta-analysis of randomized
   controlled trials
SO NUTRITION REVIEWS
LA English
DT Review
DE carbohydrate; diastolic blood pressure; isocaloric diet; macronutrient;
   meta-analysis; monounsaturated fatty acid; randomized controlled trial;
   systematic review; systolic blood pressure
ID CARDIOVASCULAR RISK-FACTORS; ENDOTHELIAL DYSFUNCTION; INSULIN
   SENSITIVITY; METABOLIC SYNDROME; OXIDATIVE STRESS; SERUM-LIPIDS;
   DISEASE; GLUCOSE; IMPROVES; NIDDM
AB Context: Current dietary guidelines for cardiovascular disease risk management recommend restricting intake of saturated fatty acids (SFAs). However, the optimal macronutrient profile, in the context of a low-SFA diet, remains controversial. The blood-pressure effect of replacing SFAs in diets with monounsaturated fatty acids (MUFAs) compared with carbohydrate has not been quantified to date. Objective: To synthesize the evidence for the effect of substituting a high-carbohydrate (high-CHO) diet for a high-monounsaturated fatty acid (high-MUFA) diet on blood pressure, a systematic review and meta-analysis of randomized clinical trials in a population without health restrictions was conducted. Data Sources: MEDLINE, EMBASE, and Cochrane Central Register of Controlled Clinical Trials were searched through June 7, 2017. Randomized controlled trials of > 3 weeks duration that assessed the effect of high-MUFA diets in isocaloric substitution for high-CHO diets on systolic blood pressure (SBP) and diastolic blood pressure (DBP) were included. Data Extraction: Data were pooled using the generic-inverse variance method with random effects models and expressed as mean differences (MDs) with 95% confidence intervals (CIs). Heterogeneity was assessed by Cochran Q statistic and quantified by the I-2 statistic. The quality of the evidence was assessed with the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) system. Results: Fourteen trials (n = 980 participants) were included in the analysis. Comparatively, the high-MUFA diets in isocaloric substitution for high-CHO diets did not demonstrate a greater reduction in blood pressure (SBP: MD, -0.08 mmHg [95% CI, -1.01 to 0.84], P = 0.86; DBP: MD = 0.01 mmHg [95% CI, -0.73 to 0.75], P = 0.98). The overall quality of the evidence was assessed as moderate. Conclusions: In the context of low SFAs, high-MUFA diets in isocaloric substitution for high-CHO diets did not affect blood pressure in individuals with and without hypertension. Large-scale trials achieving higher MUFA targets are required to support these findings.
C1 [Jovanovski, Elena; Ruiz Marques, Any de Castro; Li, Dandan; Ho, Hoang V. T.; Mejia, Sonia Blanco; Sievenpiper, John L.; Zurbau, Andreea; Komishon, Allison; Vuksan, Vladimir] St Michaels Hosp, Clin Nutr & Risk Factor Modificat Ctr, 30 Bond St, Toronto, ON M5B 1M8, Canada.
   [Jovanovski, Elena; Li, Dandan; Ho, Hoang V. T.; Mejia, Sonia Blanco; Sievenpiper, John L.; Zurbau, Andreea; Vuksan, Vladimir] Univ Toronto, Fac Med, Dept Nutr Sci, Toronto, ON, Canada.
   [Ruiz Marques, Any de Castro; Bazotte, Roberto B.] Univ Estadual Maringa, Dept Pharmacol & Therapeut, Maringa, Parana, Brazil.
   [Ho, Hoang V. T.; Sievenpiper, John L.; Vuksan, Vladimir] St Michaels Hosp, Li Ka Shing Knowledge Inst, Toronto, ON, Canada.
   [Ho, Hoang V. T.; Sievenpiper, John L.; Vuksan, Vladimir] St Michaels Hosp, Div Endocrinol & Metab, Toronto, ON, Canada.
   [Ho, Hoang V. T.; Mejia, Sonia Blanco; Sievenpiper, John L.] St Michaels Hosp, Toronto 3D Knowledge Synth & Clin Trials Unit, Toronto, ON, Canada.
   [Duvnjak, Lea] Univ Zagreb, Univ Hosp Merkur, Sch Med, Clin Diabet Endocrinol & Metab Dis Vuk Vrhovac, Zagreb, Croatia.
C3 University of Toronto; Saint Michaels Hospital Toronto; University of
   Toronto; Universidade Estadual de Maringa; University of Toronto; Saint
   Michaels Hospital Toronto; Li Ka Shing Knowledge Institute; University
   of Toronto; Saint Michaels Hospital Toronto; University of Toronto;
   Saint Michaels Hospital Toronto; University of Zagreb
RP Vuksan, V (corresponding author), St Michaels Hosp, Clin Nutr & Risk Factor Modificat Ctr, 30 Bond St, Toronto, ON M5B 1M8, Canada.
EM v.vuksan@utoronto.ca
RI BAZOTTE, ROBERTO/S-5851-2019; Sievenpiper, John/JVN-7555-2024
FU PSI Graham Farquharson Knowledge Translation Fellowship; Diabetes Canada
   Clinician Scientist award; Canadian Institutes of Health Research (CIHR)
   Institute of Nutrition, Metabolism and Diabetes (INMD)/Canadian
   Nutrition Society (CNS) New Investigator Partnership Prize; Banting &
   Best Diabetes Centre Sun Life Financial New Investigator Award
FX There was no direct funding for the project. J.L.S. was funded by a PSI
   Graham Farquharson Knowledge Translation Fellowship, Diabetes Canada
   Clinician Scientist award, Canadian Institutes of Health Research (CIHR)
   Institute of Nutrition, Metabolism and Diabetes (INMD)/Canadian
   Nutrition Society (CNS) New Investigator Partnership Prize, and Banting
   & Best Diabetes Centre Sun Life Financial New Investigator Award. None
   of the sponsors had a role in any aspect of the present study, including
   design and conduct of the study; collection, management, analysis, and
   interpretation of the data; and preparation, review, approval of the
   manuscript, or decision to publish.
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NR 64
TC 22
Z9 21
U1 0
U2 19
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0029-6643
EI 1753-4887
J9 NUTR REV
JI Nutr. Rev.
PD JAN
PY 2019
VL 77
IS 1
BP 19
EP 31
DI 10.1093/nutrit/nuy040
PG 13
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA HH8ZS
UT WOS:000456023400002
PM 30165599
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Kataoka, T
   Hotta, Y
   Maeda, Y
   Kimura, K
AF Kataoka, Tomoya
   Hotta, Yuji
   Maeda, Yasuhiro
   Kimura, Kazunori
TI Assessment of Androgen Replacement Therapy for Erectile Function in Rats
   with Type 2 Diabetes Mellitus by Examining Nitric Oxide-Related and
   Inflammatory Factors
SO JOURNAL OF SEXUAL MEDICINE
LA English
DT Article
DE Erectile Dysfunction; Testosterone; Obesity; Type 2 Diabetes Mellitus;
   Endothelial Dysfunction; Inflammation; Androgen Replacement Therapy
ID METABOLIC-SYNDROME; INSULIN-RESISTANCE; OXIDATIVE STRESS; ANIMAL-MODEL;
   OLETF RATS; DYSFUNCTION; TESTOSTERONE; MEN; VARDENAFIL; OBESITY
AB IntroductionType 2 diabetes mellitus (T2DM) has become a major public health issue and is considered a risk factor for erectile dysfunction (ED). T2DM is also associated with androgen deficiency. However, there have been few basic studies on androgen replacement therapy (ART) for ED treatment in T2DM animal models, and the mechanism underlying the effect of ART on T2DM-induced ED is unclear.
   AimTo investigate the effect of ART on ED in T2DM rats by examining inflammatory and nitric oxide (NO)-related factors.
   MethodsOtsuka Long-Evans Tokushima Fatty (OLETF) rats and their controls, Long-Evans Tokushima Otsuka (LETO) rats, were distributed into three groups: LETO, OLETF, and ART. In the ART group, OLETF rats were treated daily with testosterone (3mg/kg/day, subcutaneously) from 20 to 25 weeks of age; LETO and OLETF rats received vehicle only.
   Main Outcome MeasuresWe measured erectile function by using measurements of the ratio between intracavernosal pressure (ICP) and mean arterial pressure (MAP) following electrical stimulation of the cavernous nerve and by evaluating the endothelial function of the corpus cavernosum in an isometric tension study. Expression of endothelial NO synthase (eNOS), inducible NO synthase (iNOS), sirtuin-1 (Sirt1), interleukin-6 (IL-6), and tumor necrosis factor alpha (TNF-) mRNA was detected using polymerase chain reaction.
   ResultsThe ICP/MAP ratio in the OLETF group was significantly decreased and that in the ART group was significantly improved (P<0.01). The response to acetylcholine was significantly decreased in the OLETF group and improved in the ART group (P<0.01). Although expression of eNOS and Sirt1 mRNA was decreased and that of iNOS, IL-6, and TNF- mRNA was increased in the OLETF group, ART improved mRNA expression.
   ConclusionsART suppressed inflammation in rats with T2DM and metabolic disorders and improved their endothelial and erectile functions. ART could be effective for T2DM-induced ED and may be considered a potential ED treatment method. Kataoka T, Hotta Y, Maeda Y, and Kimura K. Assessment of androgen replacement therapy for erectile function in rats with type 2 diabetes mellitus by examining nitric oxide-related and inflammatory factors. J Sex Med 2014;11:920-929.
C1 [Kataoka, Tomoya; Hotta, Yuji; Maeda, Yasuhiro; Kimura, Kazunori] Nagoya City Univ, Grad Sch Pharmaceut Sci, Dept Hosp Pharm, Nagoya, Aichi 4678601, Japan.
   [Kimura, Kazunori] Nagoya City Univ, Dept Clin Pharm, Grad Sch Med Sci, Nagoya, Aichi 4678601, Japan.
RP Kimura, K (corresponding author), Nagoya City Univ, Dept Clin Pharm, Grad Sch Med Sci, 1 Kawasumi,Mizuho Cho, Nagoya, Aichi 4678601, Japan.
EM kkimura@med.nagoya-cu.ac.jp
RI HOTTA, YUJI/ADQ-0667-2022; Kataoka, Tomoya/HTM-3619-2023
OI Kataoka, Tomoya/0000-0001-9683-4680; HOTTA, Yuji/0000-0002-9474-7775
FU Otsuka Pharmaceutical Co., Ltd.
FX The authors thank Otsuka Pharmaceutical Co., Ltd. for partially
   financing the purchase of the OLETF and LETO rats.
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NR 43
TC 35
Z9 38
U1 0
U2 7
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1743-6095
EI 1743-6109
J9 J SEX MED
JI J. Sex. Med.
PD APR
PY 2014
VL 11
IS 4
BP 920
EP 929
DI 10.1111/jsm.12447
PG 10
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA AE0RD
UT WOS:000333672900010
PM 24467772
DA 2025-06-11
ER

PT J
AU Ryan, AS
   Ge, S
   Blumenthal, JB
   Serra, MC
   Prior, SJ
   Goldberg, AP
AF Ryan, Alice S.
   Ge, Shealinna
   Blumenthal, Jacob B.
   Serra, Monica C.
   Prior, Steven J.
   Goldberg, Andrew P.
TI Aerobic Exercise and Weight Loss Reduce Vascular Markers of Inflammation
   and Improve Insulin Sensitivity in Obese Women
SO JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
LA English
DT Article
DE diet; insulin sensitivity; inflammation; exercise
ID C-REACTIVE PROTEIN; ACUTE-PHASE PROTEINS; SERUM AMYLOID-A; METABOLIC
   SYNDROME; ADIPOSE-TISSUE; ENDOTHELIAL FUNCTION; OXIDATIVE STRESS; STROKE
   INCIDENCE; SEX-DIFFERENCES; SECULAR TRENDS
AB Objectives
   To examine the relationships between plasma and tissue markers of systemic and vascular inflammation and obesity and insulin resistance and determine the effects of aerobic exercise training plus weight loss (AEX+WL) and weight loss (WL) alone on these biomarkers.
   Design
   Prospective controlled study.
   Setting
   Veterans Affairs Medical Center and University research setting.
   Participants
   Overweight and obese sedentary postmenopausal women (N=77).
   Interventions
   Six months, 3d/wk AEX+WL (n= 37) or WL (n=40).
   Measurements
   Total-body dual-energy X-ray absorptiometry, abdominal computed tomography, hyperinsulinemic-euglycemic clamps (a criterion standard method of assessing insulin sensitivity), adipose tissue biopsies (n=28), and blood for homeostasis model assessment-insulin resistance, and soluble forms of intracellular adhesion molecule 1 (sICAM-1) and vascular cell adhesion molecule 1 (sVCAM-1), C-reactive protein (CRP), and serum amyloid A (SAA).
   Results
   Body weight (P<.001), percentage of fat (P<.001), visceral fat (P<.005), triglyceride levels (P<.001), and systolic blood pressure decreased comparably after WL and AEX+WL (P=.04). Maximal oxygen consumption increased 16% after AEX+WL (P<.001). Insulin resistance decreased in both groups (P=.005). Glucose utilization according to the clamp increased 10% (P=.04) with AEX+WL and 8% with WL (P=.07). AEX+WL decreased CRP by 29% (P<.001) and WL by 21% (P=.02). SAA levels decreased twice as much after AEX+WL (-19%, P=.02) as after WL (-9%, P=.08). Plasma sICAM-1 and sVCAM-1 levels did not change, but women with the greatest reduction in plasma sICAM-1 levels had the greatest reductions in fasting glucose (P=.02), insulin (P=.02), and insulin resistance (P=.004). Gluteal ICAM messenger ribonucleic acid levels decreased 27% after AEX+WL (P=.02) and did not change after WL.
   Conclusion
   Obesity and insulin resistance worsen markers of systemic and vascular inflammation. A reduction in plasma sICAM-1 is important to improve insulin sensitivity. CRP, SAA, and tissue ICAM decrease with exercise and weight loss, suggesting that exercise training is a necessary component of lifestyle modification in obese postmenopausal women.
C1 [Ryan, Alice S.; Blumenthal, Jacob B.; Serra, Monica C.; Prior, Steven J.; Goldberg, Andrew P.] Baltimore Vet Affairs Med Ctr, Baltimore, MD 21201 USA.
   [Ryan, Alice S.; Blumenthal, Jacob B.; Serra, Monica C.; Prior, Steven J.; Goldberg, Andrew P.] Vet Affairs Maryland Hlth Care Syst, Res & Dev Serv, Baltimore, MD USA.
   [Ryan, Alice S.; Ge, Shealinna; Blumenthal, Jacob B.; Serra, Monica C.; Prior, Steven J.; Goldberg, Andrew P.] Univ Maryland, Sch Med, Dept Med, Div Gerontol & Geriatr Med, Baltimore, MD 21201 USA.
   [Ryan, Alice S.; Blumenthal, Jacob B.; Serra, Monica C.; Prior, Steven J.; Goldberg, Andrew P.] Baltimore Geriatr Res Educ & Clin Ctr, Baltimore, MD USA.
C3 US Department of Veterans Affairs; Veterans Health Administration (VHA);
   Baltimore VA Medical Center; University System of Maryland; University
   of Maryland Baltimore; Geriatric Research Education & Clinical Center
RP Ryan, AS (corresponding author), Baltimore Vet Affairs Med Ctr, Div Gerontol & Geriatr Med, BT 18 GR,10 N Greene St, Baltimore, MD 21201 USA.
EM aryan@grecc.umaryland.edu
RI Prior, Steven/AAC-8232-2020
FU Veterans Affairs (VA) Research Career Scientist Award; VA Merit Award;
   Baltimore VA Medical Center Geriatric Research, Education and Clinical
   Center; VA Career Development Awards [T32-AG-00219]; National Institutes
   of Health [R01-AG-019310, RO1-AG-20116]; General Clinical Research
   Center [M01 RR016500]; Nutrition, Obesity, Research Center of Maryland
   [DK072488]; University of Maryland Claude D. Pepper Center
   [P30-AG-12583]
FX This research was supported by a Veterans Affairs (VA) Research Career
   Scientist Award (ASR), VA Merit Award (ASR), the Baltimore VA Medical
   Center Geriatric Research, Education and Clinical Center, VA Career
   Development Awards (JBB and SJP), T32-AG-00219, National Institutes of
   Health Grant R01-AG-019310 (ASR), RO1-AG-20116 (APG), General Clinical
   Research Center (#M01 RR016500), Nutrition, Obesity, Research Center of
   Maryland (DK072488), and the University of Maryland Claude D. Pepper
   Center (P30-AG-12583). Clinical Trials: NCT00882141.
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NR 55
TC 61
Z9 72
U1 0
U2 33
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0002-8614
EI 1532-5415
J9 J AM GERIATR SOC
JI J. Am. Geriatr. Soc.
PD APR
PY 2014
VL 62
IS 4
BP 607
EP 614
DI 10.1111/jgs.12749
PG 8
WC Geriatrics & Gerontology; Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA AE8YV
UT WOS:000334289900002
PM 24635342
OA Green Accepted
DA 2025-06-11
ER

PT J
AU García, RA
   Search, DJ
   Lupisella, JA
   Ostrowski, J
   Guan, B
   Chen, J
   Yang, WP
   Truong, A
   He, AQ
   Zhang, RG
   Yan, MJ
   Hellings, SE
   Gargalovic, PS
   Ryan, CS
   Watson, LM
   Langish, RA
   Shipkova, PA
   Carson, NL
   Taylor, JR
   Yang, R
   Psaltis, GC
   Harrity, TW
   Robl, JA
   Gordon, DA
AF Garcia, Ricardo A.
   Search, Debra J.
   Lupisella, John A.
   Ostrowski, Jacek
   Guan, Bo
   Chen, Jian
   Yang, Wen-Pin
   Amy Truong
   He, Aiqing
   Zhang, Rongan
   Yan, Mujing
   Hellings, Samuel E.
   Gargalovic, Peter S.
   Ryan, Carol S.
   Watson, Linda M.
   Langish, Robert A.
   Shipkova, Petia A.
   Carson, Nancy L.
   Taylor, Joseph R.
   Yang, Richard
   Psaltis, George C.
   Harrity, Thomas W.
   Robl, Jeffrey A.
   Gordon, David A.
TI 11β-Hydroxysteroid Dehydrogenase Type 1 Gene Knockout Attenuates
   Atherosclerosis and In Vivo Foam Cell Formation in Hyperlipidemic
   apoE<SUP>-/-</SUP> Mice
SO PLOS ONE
LA English
DT Article
ID LOW-DENSITY-LIPOPROTEIN; TOLL-LIKE RECEPTOR-4; METABOLIC SYNDROME;
   CARDIOVASCULAR-DISEASE; VISCERAL OBESITY; OXIDIZED LDL; MACROPHAGES;
   INHIBITION; ACCUMULATION; APOPTOSIS
AB Background: Chronic glucocorticoid excess has been linked to increased atherosclerosis and general cardiovascular risk in humans. The enzyme 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta HSD1) increases active glucocorticoid levels within tissues by catalyzing the conversion of cortisone to cortisol. Pharmacological inhibition of 11 beta HSD1 has been shown to reduce atherosclerosis in murine models. However, the cellular and molecular details for this effect have not been elucidated.
   Methodology/Principal Findings: To examine the role of 11 beta HSD1 in atherogenesis, 11 beta HSD1 knockout mice were created on the pro-atherogenic apoE(-/-) background. Following 14 weeks of Western diet, aortic cholesterol levels were reduced 50% in 11 beta HSD1(-/-)/apoE(-/-) mice vs. 11 beta HSD1(+/+)/apoE(-/-) mice without changes in plasma cholesterol. Aortic 7-ketocholesterol content was reduced 40% in 11 beta HSD1(-/-)/apoE(-/-) mice vs. control. In the aortic root, plaque size, necrotic core area and macrophage content were reduced similar to 30% in 11 beta HSD1(-/-)/apoE(-/-) mice. Bone marrow transplantation from 11 beta HSD1(-/-)/apoE(-/-) mice into apoE(-/-) recipients reduced plaque area 39-46% in the thoracic aorta. In vivo foam cell formation was evaluated in thioglycollate-elicited peritoneal macrophages from 11 beta HSD1(+/+)/apoE(-/-) and 11 beta HSD1(-/-)/apoE(-/-) mice fed a Western diet for similar to 5 weeks. Foam cell cholesterol levels were reduced 48% in 11 beta HSD1(-/-)/apoE(-/-) mice vs. control. Microarray profiling of peritoneal macrophages revealed differential expression of genes involved in inflammation, stress response and energy metabolism. Several toll-like receptors (TLRs) were downregulated in 11 beta HSD1(-/-)/apoE(-/-) mice including TLR 1, 3 and 4. Cytokine release from 11 beta HSD1(-/-)/apoE(-/-)-derived peritoneal foam cells was attenuated following challenge with oxidized LDL.
   Conclusions: These findings suggest that 11 beta HSD1 inhibition may have the potential to limit plaque development at the vessel wall and regulate foam cell formation independent of changes in plasma lipids. The diminished cytokine response to oxidized LDL stimulation is consistent with the reduction in TLR expression and suggests involvement of 11 beta HSD1 in modulating binding of pro-atherogenic TLR ligands.
C1 [Garcia, Ricardo A.; Search, Debra J.; Lupisella, John A.; Ostrowski, Jacek; Zhang, Rongan; Yan, Mujing; Hellings, Samuel E.; Gargalovic, Peter S.; Ryan, Carol S.; Carson, Nancy L.; Yang, Richard; Harrity, Thomas W.; Gordon, David A.] Bristol Myers Squibb Co, Cardiovasc Drug Discovery, Pennington, NJ 08534 USA.
   [Guan, Bo; Chen, Jian; Yang, Wen-Pin; Amy Truong; He, Aiqing] Bristol Myers Squibb Co, Appl Genom, Pennington, NJ USA.
   [Watson, Linda M.] Bristol Myers Squibb Co, Pharmaceut Compound Optimizat Discovery Toxicol, Lawrenceville, NJ USA.
   [Langish, Robert A.; Shipkova, Petia A.] Bristol Myers Squibb Co, Pharmaceut Compound Optimizat Discovery Analyt Sc, Pennington, NJ USA.
   [Taylor, Joseph R.] Bristol Myers Squibb Co, Metab Dis, Pennington, NJ USA.
   [Psaltis, George C.] Bristol Myers Squibb Co, Vet Sci, Pennington, NJ USA.
   [Robl, Jeffrey A.] Bristol Myers Squibb Co, Discovery Chem, Pennington, NJ USA.
C3 Bristol-Myers Squibb; Bristol-Myers Squibb; Bristol-Myers Squibb;
   Bristol-Myers Squibb; Bristol-Myers Squibb; Bristol-Myers Squibb;
   Bristol-Myers Squibb
RP Gordon, DA (corresponding author), Bristol Myers Squibb Co, Cardiovasc Drug Discovery, Pennington, NJ 08534 USA.
EM david.gordon@bms.com
OI Lupisella, John/0000-0003-1343-6412
FU Bristol-Myers Squibb Company
FX Studies described in this report were funded by Bristol-Myers Squibb
   Company. The funders had no role in study design, data collection and
   analysis, decision to publish, or preparation of the manuscript.
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NR 48
TC 27
Z9 27
U1 0
U2 17
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD FEB 1
PY 2013
VL 8
IS 2
AR e53192
DI 10.1371/journal.pone.0053192
PG 15
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 085EU
UT WOS:000314597900004
PM 23383297
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Muniyappa, R
   Sachdev, V
   Sidenko, S
   Ricks, M
   Castillo, DC
   Courville, AB
   Sumner, AE
AF Muniyappa, Ranganath
   Sachdev, Vandana
   Sidenko, Stanislav
   Ricks, Madia
   Castillo, Darleen C.
   Courville, Amber B.
   Sumner, Anne E.
TI Postprandial endothelial function does not differ in women by race: an
   insulin resistance paradox?
SO AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
LA English
DT Article
DE African Americans; endothelial function
ID AFRICAN-AMERICAN PATIENTS; FLOW-MEDIATED DILATION; HIGH-FAT MEAL;
   VASCULAR REACTIVITY; RACIAL-DIFFERENCES; METABOLIC SYNDROME; OXIDATIVE
   STRESS; BRACHIAL-ARTERY; ETHNIC-DIFFERENCES; DIABETES-MELLITUS
AB Muniyappa R, Sachdev V, Sidenko S, Ricks M, Castillo DC, Courville AB, Sumner AE. Postprandial endothelial function does not differ in women by race: an insulin resistance paradox? Am J Physiol Endocrinol Metab 302: E218-E225, 2012. First published November 1, 2011; doi: 10.1152/ajpendo.00434.2011.-Insulin resistance is associated with endothelial dysfunction. Because African-American women are more insulin-resistant than white women, it is assumed that African-American women have impaired endothelial function. However, racial differences in postprandial endothelial function have not been examined. In this study, we test the hypothesis that African-American women have impaired postprandial endothelial function compared with white women. Postprandial endothelial function following a breakfast (20% protein, 40% fat, and 40% carbohydrate) was evaluated in 36 (18 AfricanAmerican women, 18 white women) age-and body mass index (BMI)-matched (age: 37 +/- 11 yr; BMI: 30 +/- 6 kg/m(2)) women. Endothelial function, defined by percent change in brachial artery flow-mediated dilation (FMD), was measured at 0, 2, 4, and 6 h following a meal. There were no significant differences between the groups in baseline FMD, total body fat, abdominal visceral fat, and fasting levels of glucose, insulin, total cholesterol, low-density lipoprotein cholesterol, or serum estradiol. Although AfricanAmerican women were less insulin-sensitive [insulin sensitivity index (mean +/- SD): 3.6 +/- 1.5 vs. 5.2 +/- 2.6, P = 0.02], both fasting triglyceride (TG: 56 +/- 37 vs. 97 +/- 49 mg/dl, P = 0.007) and incremental TG area under the curve (AUC(0-6hr): 279 +/- 190 vs. 492 +/- 255 mg.dl(-1).min(-1).10(-2), P = 0.008) were lower in African-American than white women. Breakfast was associated with a significant increase in FMD in whites and African-Americans, and there was no significant difference in postprandial FMD between the groups (P > 0.1 for group x time interactions). Despite being insulin-resistant, postprandial endothelial function in African-American women was comparable to white women. These results imply that insulin sensitivity may not be an important determinant of racial differences in endothelial function.
C1 [Muniyappa, Ranganath] NIDDK, Diabet Endocrinol & Obes Branch, Intramural Program, Bethesda, MD 20892 USA.
   [Sachdev, Vandana; Sidenko, Stanislav] NHLBI, Cardiovasc & Pulm Branch, Bethesda, MD 20892 USA.
   [Courville, Amber B.] NIH, Dept Nutr, Ctr Clin, Bethesda, MD 20892 USA.
C3 National Institutes of Health (NIH) - USA; NIH National Institute of
   Diabetes & Digestive & Kidney Diseases (NIDDK); National Institutes of
   Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI);
   National Institutes of Health (NIH) - USA; NIH Clinical Center (CC)
RP Muniyappa, R (corresponding author), NIDDK, Diabet Endocrinol & Obes Branch, Intramural Program, 10 Ctr Dr,Bldg 10,Rm 4-1730,MSC 1302, Bethesda, MD 20892 USA.
EM muniyapr@mail.nih.gov
FU National Institute of Diabetes and Digestive and Kidney Diseases;
   National Heart, Lung, and Blood Institute, National Institutes of Health
FX This work was supported by the Intramural Research Programs of National
   Institute of Diabetes and Digestive and Kidney Diseases and National
   Heart, Lung, and Blood Institute, National Institutes of Health.
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NR 54
TC 14
Z9 14
U1 0
U2 2
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0193-1849
EI 1522-1555
J9 AM J PHYSIOL-ENDOC M
JI Am. J. Physiol.-Endocrinol. Metab.
PD JAN
PY 2012
VL 302
IS 2
BP E218
EP E225
DI 10.1152/ajpendo.00434.2011
PG 8
WC Endocrinology & Metabolism; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Physiology
GA 876MX
UT WOS:000299112700007
PM 22045315
OA Green Published
DA 2025-06-11
ER

PT J
AU Rutters, F
   Nieuwenhuizen, AG
   Lemmens, SGT
   Born, JM
   Westerterp-Plantenga, MS
AF Rutters, Femke
   Nieuwenhuizen, Arie G.
   Lemmens, Sofie G. T.
   Born, Jurriaan M.
   Westerterp-Plantenga, Margriet S.
TI Hypothalamic-Pituitary-Adrenal (HPA) axis functioning in relation to
   body fat distribution
SO CLINICAL ENDOCRINOLOGY
LA English
DT Article
ID X-RAY ABSORPTIOMETRY; CORTISOL SECRETION; VISCERAL FAT; OBESE WOMEN;
   NEUROENDOCRINE FACTORS; METABOLIC SYNDROME; ABDOMINAL OBESITY;
   DOSE-RESPONSE; STRESS; MEN
AB Objective To relate hypothalamic-pituitary-adrenal (HPA) axis functioning and HPA feedback functioning to body fat distribution in normal weight to obese subjects.
   Patients 91 men and 103 women [age 18-45 years, BMI 19-35 kg/m(2), waist-to-hip ratio (WHR) 0.6-1.1]
   Measurements Anthropometry, body composition using hydrodensitometry and deuterium dilution method, cortisol variability by measuring 5-h cortisol concentrations, HPA axis feedback functioning using a dexamethasone suppression test, and HPA axis functioning under a challenged condition consisting of a standardized high-intensity test with ingestion of 4 mg dexamethasone.
   Results In men, an inverse relationship was observed between 5-h cortisol exposure (nmol/ml) and fat mass index (FMI) (kg/m(2)) (r = -0.55, P < 0.001). In women, relationships were observed between 5-h cortisol exposure (nmol/ml.min) and WHR (r = -0.49, P < 0.001), maximal workload (r = 0.32, P < 0.001) as well as oral contraceptive use (r = 0.38, P < 0.001). Similarly, in men, an inverse relationship was observed between negative feedback expressed as baseline concentrations minus post dexamethasone cortisol concentrations (nmol/ml) and FMI (r = -0.53, P < 0.001). In women, relationships were observed between negative feedback expressed as baseline concentrations minus post dexamethasone cortisol concentrations (nmol/ml) and WHR (r = -0.43, P < 0.001), maximal workload (r = 0.30, P < 0.001) as well as oral contraceptive use (r = 0.43, P < 0.001) in women. Moreover, an inverse relationship was observed between HPA axis functioning in a challenged condition expressed as percentage increase of cortisol concentrations after standardized high-intensity test with ingestion of 4 mg dexamethasone (%) and waist circumference (r = 0.21, P < 0.10) in men and WHR (r = 0.21, P < 0 05) in women. In men, strong positive relationships were observed between FMI and waist circumference (r = 0 85, P < 0 001), as well as waist-to-hip ratio (r = 0 70, P < 0 001).
   Conclusion Disturbance of HPA axis functioning under basal and challenged conditions is related to visceral fat accumulation.
C1 [Rutters, Femke; Nieuwenhuizen, Arie G.; Lemmens, Sofie G. T.; Born, Jurriaan M.; Westerterp-Plantenga, Margriet S.] Maastricht Univ, Dept Human Biol, NL-6200 MD Maastricht, Netherlands.
C3 Maastricht University
RP Rutters, F (corresponding author), Maastricht Univ, Dept Human Biol, POB 616, NL-6200 MD Maastricht, Netherlands.
EM F.Rutters@hb.unimaas.nl
OI Nieuwenhuizen, Arie/0000-0003-0999-5422
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NR 32
TC 37
Z9 40
U1 0
U2 4
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0300-0664
EI 1365-2265
J9 CLIN ENDOCRINOL
JI Clin. Endocrinol.
PD JUN
PY 2010
VL 72
IS 6
BP 738
EP 743
DI 10.1111/j.1365-2265.2009.03712.x
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 598VD
UT WOS:000277866200004
PM 19769618
DA 2025-06-11
ER

PT J
AU Grabczewska, Z
   Thews, M
   Goralczyk, K
   Kubica, J
AF Grabczewska, Zofia
   Thews, Maciej
   Goralczyk, Krzysztof
   Kubica, Jacek
TI Endothelial function in patients with chest pain and normal coronary
   angiograms
SO KARDIOLOGIA POLSKA
LA English
DT Article
DE endothelium; dysfunction; methods of examination
ID ARTERY-DISEASE; BRACHIAL-ARTERY; DYSFUNCTION; RISK; ATHEROSCLEROSIS;
   STRESS
AB Background: A normal coronary angiogram is found in about 20% of patients who undergo coronary angiography due to chest pain. In some of them syndrome X is diagnosed. Endothelial dysfunction is one possible cause of this pathology.
   Aim: To compare the endothelial function estimated by two different methods in patients with typical or atypical anginal pain and with no chest pain.
   Methods: Fifty-three patients who underwent coronary angiography due to suspected coronary artery disease and who had a normal coronary angiogram were included in the study: 34 patients had typical anginal pain (group 1) and 19 patients had atypical chest pain (group 2). The control group consisted with 20 subjects without chest pain. The plasma concentration of such endothelial markers as von Willebrand factor (vWF), thrombomodulin (TM), endothelin 1 (ET-1), tissue plasminogen activator (tPA), plasminogen activator inhibitor type 1 (PAI-1) and C-reactive protein were measured. We also determined endothelial-dependent brachial arterial dilatation (flow-mediated dilation, FMD).
   Results: The groups of patients were different with regard to the factors of known effects on endothelial function but endothelial markers were not different in all groups with two exceptions. The concentration of tPA was the highest in patients with typical chest pain and the concentration of PAI-1 was the highest in patients without chest pain. The FMD values were low in all patients and there were no significant differences in the FMD values between the three analysed groups. We did not find any correlation between the concentration of examined endothelial markers and FMD. A non-significant relationship between the presence of classical risk factors and decreased FMP was observed. We have found a significant relationship between the number of risk factors and FMD, tPA, PAI-1 and hsCRP.
   Conclusions: The assessment of endothelial function using FMD or estimation of endothelial markers is not useful to differentiate chest pain.
C1 [Grabczewska, Zofia; Kubica, Jacek] A Jurasz Univ Hosp, Chair & Dept Cardiol & Internal Dis, PL-85094 Bydgoszcz, Poland.
   [Thews, Maciej] A Jurasz Univ Hosp, Chair & Dept Gen & Vasc Surg, PL-85094 Bydgoszcz, Poland.
   [Goralczyk, Krzysztof] Nicholas Copernicus Univ, Coll Med, Chair & Dept Pathophysiol, Torun, Poland.
C3 Nicolaus Copernicus University
RP Grabczewska, Z (corresponding author), A Jurasz Univ Hosp, Chair & Dept Cardiol & Internal Dis, Ul Marii Sklodowskiej Curie 9, PL-85094 Bydgoszcz, Poland.
EM z.grabczewska@cm.umk.pl
RI Góralczyk, Krzysztof/H-4715-2014; Grąbczewska, Zofia/H-5015-2014;
   Kubica, Jacek/D-6906-2014
OI Grabczewska, Zofia/0000-0002-4449-6699; Goralczyk,
   Krzysztof/0000-0002-0804-6412; Kubica, Jacek/0000-0001-8250-754X
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NR 31
TC 8
Z9 9
U1 0
U2 0
PU VIA MEDICA
PI GDANSK
PA UL SWIETOKRZYSKA 73, 80-180 GDANSK, POLAND
SN 0022-9032
EI 1897-4279
J9 KARDIOL POL
JI Kardiol. Pol.
PD OCT
PY 2007
VL 65
IS 10
BP 1199
EP +
PG 9
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 281IV
UT WOS:000254491000005
PM 17979048
DA 2025-06-11
ER

PT J
AU Spiekermann, J
   Sinningen, K
   Hanusch, B
   Kleber, M
   Schündeln, MM
   Kiewert, C
   Siggelkow, H
   Höppner, J
   Grasemann, C
AF Spiekermann, Julia
   Sinningen, Kathrin
   Hanusch, Beatrice
   Kleber, Michaela
   Schuendeln, Michael M.
   Kiewert, Cordula
   Siggelkow, Heide
   Hoeppner, Jakob
   Grasemann, Corinna
TI Cardiorespiratory fitness in adolescents and young adults with
   Klinefelter syndrome - a pilot study
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Article
DE Klinefelter syndrome; XXY; adolescence; children; cardiovascular
   disease; chronotropic insufficiency; physical activity
ID INSULIN-RESISTANCE; METABOLIC SYNDROME; PHYSICAL-ACTIVITY; HEART-RATE;
   MORTALITY; PREDICTOR; CHILDREN
AB BackgroundKlinefelter syndrome (KS) may be associated with a wide spectrum of phenotypic changes including endocrine, metabolic, cognitive, psychiatric and cardiorespiratory pathologies in adults. However, in adolescence the clinical phenotype of KS is not well described, especially regarding physical fitness. The present study reports on cardiorespiratory function in adolescents and young adults with KS. MethodsAdolescents and young adults with KS were recruited in a cross-sectional pilot study. Biochemical parameters of fitness including hormonal status, a body impedance analysis, the grip strength, the amount of physical activity at home for 5 days via trackbands and anamnestic parameters were assessed. In addition, participants underwent an incremental symptom-limited cardiopulmonary exercise test (CPET) on a bicycle ergometer. ResultsNineteen participants with KS aged 15.90 +/- 4.12 years (range: 9.00 - 25.00) participated in the study. Pubertal status was Tanner 1 (n = 2), Tanner 2 - 4 (n = 7) and Tanner 5 (n = 10). Seven participants received testosterone replacement therapy. Mean BMI z-score was 0.45 +/- 1.36 and mean fat mass was 22.93% +/- 9.09. Grip strength was age-appropriate or above normal. 18 participants underwent CPET with subnormal results for maximum heart rate (z-score -2.84 +/- 2.04); maximum workload (Watt(max); z score -1.28 +/- 1.15) and maximum oxygen uptake per minute (z- score -2.25 +/- 2.46). Eight participants (42.1%) met the criteria for chronotropic insufficiency (CI). Data from track-bands showed sedentary behavior for 81.15% +/- 6.72 of the wear time. ConclusionA substantial impairment of cardiopulmonary function can be detected in this group of boys to young adults with KS, including chronotropic insufficiency in 40%. The track-band data suggest a predominantly sedentary lifestyle, despite normal muscular strength as assessed via grip strength. Future studies need to investigate the cardiorespiratory system and its adaption to physical stress in a larger cohort and in more detail. It is feasible that the observed impairments contribute to the avoidance of sports in individuals with KS and may contribute to the development of obesity and the unfavorable metabolic phenotype.
C1 [Spiekermann, Julia; Sinningen, Kathrin; Hanusch, Beatrice; Kleber, Michaela; Hoeppner, Jakob; Grasemann, Corinna] Ruhr Univ Bochum, Univ Hosp Pediat & Adolescent Med, St Josef Hosp, Bochum, Germany.
   [Spiekermann, Julia; Hoeppner, Jakob; Grasemann, Corinna] Ruhr Univ Bochum, Ctr Rare Dis Ruhr CeSER, Witten, Germany.
   [Spiekermann, Julia; Hoeppner, Jakob; Grasemann, Corinna] Witten Herdecke Univ, Witten, Germany.
   [Schuendeln, Michael M.] Univ Duisburg Essen, Univ Hosp Essen, Dept Pediat 3, Div Pediat Hematol & Oncol, Essen, Germany.
   [Kiewert, Cordula] Univ Duisburg Essen, Univ Hosp Essen, Dept Pediat 2, Div Pediat Endocrinol, Essen, Germany.
   [Siggelkow, Heide] Univ Med Ctr Goettingen, Clin Gastroenterol Gastrointestinal Oncol & Endoc, Gottingen, Germany.
   [Siggelkow, Heide] MVZ Endokrinol Goettingen, Gottingen, Germany.
C3 Ruhr University Bochum; Ruhr University Bochum; University of Duisburg
   Essen; University of Duisburg Essen; University of Gottingen; UNIVERSITY
   GOTTINGEN HOSPITAL
RP Grasemann, C (corresponding author), Ruhr Univ Bochum, Univ Hosp Pediat & Adolescent Med, St Josef Hosp, Bochum, Germany.; Grasemann, C (corresponding author), Ruhr Univ Bochum, Ctr Rare Dis Ruhr CeSER, Witten, Germany.; Grasemann, C (corresponding author), Witten Herdecke Univ, Witten, Germany.
EM corinna.grasemann@rub.de
RI Hanusch, Beatrice/IQR-6557-2023; Grasemann, Corinna/AAG-3861-2021;
   Schündeln, Michael/W-3455-2018; Sinningen, Kathrin/AFM-6340-2022;
   Höppner, Jakob/ADQ-8953-2022
OI Hoppner, Jakob/0000-0001-9908-2066; Hanusch,
   Beatrice/0000-0003-3495-4614; Spiekermann, Julia/0000-0002-9461-7727;
   Grasemann, Corinna/0000-0003-1793-4603
FU Deutsche Gesellschaft fuer Sozialpaediatrie und Jugendmedizin; Open
   Access Publication Funds' of the Ruhr-University Bochum
FX The study was supported by funding from the "Deutsche Gesellschaft fuer
   Sozialpaediatrie und Jugendmedizin". The online publication of this
   study has been supported by the Open Access Publication Funds' of the
   Ruhr-University Bochum.
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NR 53
TC 1
Z9 1
U1 0
U2 3
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD JAN 30
PY 2023
VL 14
AR 1106118
DI 10.3389/fendo.2023.1106118
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 8X2QI
UT WOS:000931861700001
PM 36793286
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Guevara-Olaya, L
   Chimal-Vega, B
   Castañeda-Sánchez, CY
   López-Cossio, LY
   Pulido-Capiz, A
   Galindo-Hernández, O
   Díaz-Molina, R
   Esparza-Cisneros, JR
   García-González, V
AF Guevara-Olaya, Lizbeth
   Chimal-Vega, Brenda
   Yahel Castaneda-Sanchez, Cesar
   Lopez-Cossio, Leslie Y.
   Pulido-Capiz, Angel
   Galindo-Hernandez, Octavio
   Diaz-Molina, Raul
   Ruiz Esparza-Cisneros, Josefina
   Garcia-Gonzalez, Victor
TI LDL Promotes Disorders in β-Cell Cholesterol Metabolism, Implications on
   Insulin Cellular Communication Mediated by EVs
SO METABOLITES
LA English
DT Article
DE beta-cells; LDL; insulin; cholesterol; metainflammation; PDX-1;
   auraptene; extracellular vesicles
ID UNFOLDED PROTEIN RESPONSE; CONVERTING ENZYME 2; GLUCOSE-HOMEOSTASIS;
   TRANSCRIPTION; SECRETION; STRESS; CA2+; HYPERCHOLESTEROLEMIA;
   LIPOTOXICITY; HNF1-ALPHA
AB Dyslipidemia is described as a hallmark of metabolic syndrome, promoting a stage of metabolic inflammation (metainflammation) that could lead to misbalances in energetic metabolism, contributing to insulin resistance, and modifying intracellular cholesterol pathways and the renin- angiotensin system (RAS) in pancreatic islets. Low-density lipoprotein (LDL) hypercholesterolemia could disrupt the tissue communication between Langerhans beta-cells and hepatocytes, wherein extracellular vesicles (EVs) are secreted by beta-cells, and exposition to LDL can impair these phenomena. beta-cells activate compensatory mechanisms to maintain insulin and metabolic homeostasis; therefore, the work aimed to characterize the impact of LDL on beta-cell cholesterol metabolism and the implication on insulin secretion, connected with the regulation of cellular communication mediated by EVs on hepatocytes. Our results suggest that beta-cells can endocytose LDL, promoting an increase in de novo cholesterol synthesis targets. Notably, LDL treatment increased mRNA levels and insulin secretion; this hyperinsulinism condition was associated with the transcription factor PDX-1. However, a compensatory response that maintains basal levels of intracellular calcium was described, mediated by the overexpression of calcium targets PMCA1/4, SERCA2, and NCX1, together with the upregulation of the unfolded protein response (UPR) through the activation of IRE1 and PERK arms to maintain protein homeostasis. The LDL treatment induced metainflammation by IL-6, NF-kappa B, and COX-2 overexpression. Furthermore, LDL endocytosis triggered an imbalance of the RAS components. LDL treatment increased the intracellular levels of cholesterol on lipid droplets; the adaptive beta-cell response was portrayed by the overexpression of cholesterol transporters ABCA1 and ABCG1. Therefore, lipotoxicity and hyperinsulinism induced by LDL were regulated by the natural compound auraptene, a geranyloxyn coumarin modulator of cholesterol-esterification by ACAT1 enzyme inhibition. EVs isolated from beta-cells impaired insulin signaling via mTOR/p70S6Koc in hepatocytes, a phenomenon regulated by auraptene. Our results show that LDL overload plays a novel role in hyperinsulinism, mechanisms associated with a dysregulation of intracellular cholesterol, lipotoxicity, and the adaptive UPR, which may be regulated by coumarin-auraptene; these conditions explain the affectations that occur during the initial stages of insulin resistance.
C1 [Guevara-Olaya, Lizbeth; Chimal-Vega, Brenda; Yahel Castaneda-Sanchez, Cesar; Lopez-Cossio, Leslie Y.; Pulido-Capiz, Angel; Galindo-Hernandez, Octavio; Diaz-Molina, Raul; Garcia-Gonzalez, Victor] Univ Autonoma Baja California, Fac Med Mexicali, Dept Bioquim, Mexicali 21000, Baja California, Mexico.
   [Guevara-Olaya, Lizbeth; Chimal-Vega, Brenda; Yahel Castaneda-Sanchez, Cesar; Lopez-Cossio, Leslie Y.; Galindo-Hernandez, Octavio; Diaz-Molina, Raul; Garcia-Gonzalez, Victor] Univ Autonoma BC, Fac Med Mexicali, Lab Multidisciplinario Estudios Metabol & Canc, Mexicali 21000, Baja California, Mexico.
   [Pulido-Capiz, Angel] Univ Autonoma Baja California, Fac Med Mexicali, Lab Biol Mol, Mexicali 21000, Baja California, Mexico.
   [Ruiz Esparza-Cisneros, Josefina] Univ Autonoma Baja California, Fac Med, Dept Nutr, Mexicali 21000, Baja California, Mexico.
C3 Universidad Autonoma de Baja California; Universidad Autonoma de Baja
   California; Universidad Autonoma de Baja California
RP García-González, V (corresponding author), Univ Autonoma Baja California, Fac Med Mexicali, Dept Bioquim, Mexicali 21000, Baja California, Mexico.; García-González, V (corresponding author), Univ Autonoma BC, Fac Med Mexicali, Lab Multidisciplinario Estudios Metabol & Canc, Mexicali 21000, Baja California, Mexico.
EM vgarcia62@uabc.edu.mx
RI Diaz-Molina, Raul/AAZ-3358-2021; García-González, Victor/AAE-8340-2020
OI Chimal-Vega, Brenda/0000-0002-2238-0708; Pulido Capiz,
   Angel/0000-0001-9650-2555
FU Coordinacion General de Posgrado e Investigacion/UABC; Fondo Sectorial
   de Investigacion para la Educacion CB 2017-2018 [A1-S-28653/SEP/CONACYT]
FX This research was supported by 21a. Convocatoria Interna de Apoyo a
   Proyectos de Investigacion (Coordinacion General de Posgrado e
   Investigacion/UABC) and Fondo Sectorial de Investigacion para la
   Educacion CB 2017-2018 (A1-S-28653/SEP/CONACYT).
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NR 79
TC 10
Z9 10
U1 1
U2 10
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2218-1989
J9 METABOLITES
JI Metabolites
PD AUG
PY 2022
VL 12
IS 8
AR 754
DI 10.3390/metabo12080754
PG 22
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 4B2CC
UT WOS:000845591500001
PM 36005626
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Ungurianu, A
   Zanfirescu, A
   Gradinaru, D
   Ionescu-Tîrgoviste, C
   Miulescu, RD
   Margina, D
AF Ungurianu, Anca
   Zanfirescu, Anca
   Gradinaru, Daniela
   Ionescu-Tirgoviste, Constantin
   Miulescu, Rucsandra Danciulescu
   Margina, Denisa
TI Interleukins and redox impairment in type 2 diabetes mellitus:
   mini-review and pilot study
SO CURRENT MEDICAL RESEARCH AND OPINION
LA English
DT Article
DE Redox impairment; inflammation; type 2 diabetes mellitus; biomarkers
ID LOW-GRADE INFLAMMATION; C-REACTIVE PROTEIN; ALL-CAUSE MORTALITY;
   OXIDATIVE STRESS; TARGETING INFLAMMATION; INSULIN-RESISTANCE; METABOLIC
   SYNDROME; PROGNOSTIC VALUE; CARDIOVASCULAR-DISEASE; DENSITY-LIPOPROTEIN
AB Type 2 diabetes mellitus (T2DM) represents a leading cause of morbidity and premature mortality, low-grade inflammation being acknowledged as a key contributor to its development and progression. A tailored therapeutic approach, based on sensitive and specific biomarkers, could allow a more accurate analysis of disease susceptibility/prognostic and of the response to treatment. Objectives: This mini-review and pilot study had two main goals: (1) reviewing the most recent literature encompassing the use of interleukins as inflammatory markers influenced by the redox imbalances in T2DM and (2) assessing parameters that conjunctly evaluate the redox impairment and inflammatory burden of T2DM patients, taking into consideration smoking status, as such group-specific biomarkers are scarcely reported in literature. Methods: Firstly, PubMed database was surveyed to select and review the relevant studies employing interleukins as T2DM biomarkers and to assess if studies using combined inflammatory-redox indices were reported. Then, routine biochemical parameters were assessed in a pilot study -T2DM patients with 3 subgroups: non-smokers, smokers and ex-smokers, were compared to a control group of non-diabetic, apparently healthy non-smokers. Protein (AOPPs, AGEs), lipid/HDL (Amplex Red-based method) oxidative damage and inflammatory status (CRP, IL-1 beta, IL-6, IL-10) biomarkers were assessed. Cytokine ratios and 2 oxidative-inflammatory status indices were developed (IH1 and IH2) and evaluated. Results: We observed significant differences in terms of serum redox and inflammatory status (AOPPs, AGEs, CRP, CRP/HDL, CRP/IL-6, IL-10/IL-6, IH1) between T2DM patients compared to control and, moreover, between the subgroups formed considering smoking status (CRP, CRP/HDL, IH1). Glycemic control strongly influenced inflammatory status biomarkers: glycemia was positively correlated with the inflammatory parameters (CRP/IL-10) and inversely with the anti-inflammatory ones (IL-10, IL-10/IL-1 beta ratio). Conclusions: Several of the assessed parameters may possess prognostic value for diabetics, especially when comparing subgroups with a different smoking history and could prove useful in clinical practice for assessing disease progress and therapeutic efficacy.
C1 [Ungurianu, Anca; Gradinaru, Daniela; Margina, Denisa] Carol Davila Univ Med & Pharm, Fac Pharm, Dept Biochem, Bucharest, Romania.
   [Zanfirescu, Anca] Carol Davila Univ Med & Pharm, Fac Pharm, Dept Pharmacol, Traian Vuia 6, Bucharest 020956, Romania.
   [Ionescu-Tirgoviste, Constantin; Miulescu, Rucsandra Danciulescu] N Paulescu Natl Inst Diabet Nutr & Metab Dis, Bucharest, Romania.
   [Miulescu, Rucsandra Danciulescu] Carol Davila Univ Med & Pharm, Fac Dent, Dept Dept Endocrinol, Bucharest, Romania.
C3 Carol Davila University of Medicine & Pharmacy; Carol Davila University
   of Medicine & Pharmacy; Carol Davila University of Medicine & Pharmacy
RP Zanfirescu, A (corresponding author), Carol Davila Univ Med & Pharm, Fac Pharm, Dept Pharmacol, Traian Vuia 6, Bucharest 020956, Romania.
EM anca.zanfirescu@umfcd.ro
RI Gradinaru, Daniela/A-4952-2019; Ungurianu, Anca/U-5657-2019; Margina,
   Denisa/J-7312-2013
OI Gradinaru, Daniela/0000-0001-7666-3108; Ungurianu,
   Anca/0000-0002-6887-1035; Zanfirescu, Anca/0009-0006-0069-7575; Margina,
   Denisa/0000-0003-3289-147X
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NR 112
TC 4
Z9 4
U1 0
U2 4
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0300-7995
EI 1473-4877
J9 CURR MED RES OPIN
JI Curr. Med. Res. Opin.
PD APR 3
PY 2022
VL 38
IS 4
BP 511
EP 522
DI 10.1080/03007995.2022.2033049
EA FEB 2022
PG 12
WC Medicine, General & Internal; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Research & Experimental Medicine
GA 0D1TJ
UT WOS:000752212500001
PM 35067142
DA 2025-06-11
ER

PT J
AU Ferguson, JJA
   Abbott, KA
   Garg, ML
AF Ferguson, Jessica J. A.
   Abbott, Kylie A.
   Garg, Manohar L.
TI Anti-inflammatory effects of oral supplementation with curcumin: a
   systematic review and meta-analysis of randomized controlled trials
SO NUTRITION REVIEWS
LA English
DT Review
DE curcumin; curcuminoids; cytokines; inflammation; inflammatory mediators;
   meta-analysis; randomized controlled trials; systematic review; turmeric
ID DOUBLE-BLIND; METABOLIC SYNDROME; OXIDATIVE STRESS;
   RHEUMATOID-ARTHRITIS; KNEE OSTEOARTHRITIS; CARDIOVASCULAR RISK;
   CLINICAL-TRIAL; PLACEBO; INFLAMMATION; PIPERINE
AB Context: Chronic inflammation is a major contributor to the development of noncommunicable diseases. Curcumin, a bioactive polyphenol from turmeric, is a well-known anti-inflammatory agent in preclinical research. Clinical evidence remains inconclusive because of discrepancies regarding optimal dosage, duration, and formulation of curcumin. Objective: The aim of this systematic review, conducted and reported in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines and checklist, was to evaluate the efficacy of curcumin supplementation on systemic inflammatory mediators, comparing dose, duration, and bioavailability status of interventions. Data Sources: The Medline, CINAHL, EMBASE, Scopus, and Cochrane literature databases were searched from 1980 to May-end 2019. Randomized controlled trials investigating effects of dietary curcumin on inflammatory mediators in humans not receiving anti-inflammatory treatment were eligible for inclusion. Two authors independently assessed titles and abstracts of identified articles for potential eligibility and respective, retrieved, full-text articles; disagreements were resolved by a third author. Evidence quality was critically appraised using the Quality Criteria Checklist for Primary Research. Data Extraction: Thirty-two trials (N = 2,038 participants) were included and 28 were meta-analyzed using a random-effects model; effect sizes were expressed as Hedges' g (95%Cl). Data Analysis: Pooled data (reported here as weighted mean difference [WMD]; 95%Cl) showed a reduction in C-reactive protein (-1.55 mg/L; -1.81 to -1.30), interleukin-6 (-1.69 pg/mL, -2.56 to -0.82), tumor necrosis factor alpha (-3.13 pg/mL; -4.62 to -1.64), IL-8 (-0.54 pg/mL; -0.82 to -0.28), monocyte chemoattractant protein-1 (-2.48 pg/mL; -3.96 to -1.00), and an increase in IL-10 (0.49 pg/mL; 0.10 to 0.88), with no effect on intracellular adhesion molecule-1. Conclusion: These findings provide evidence for the anti-inflammatory effects of curcumin and support further investigation to confirm dose, duration, and formulation to optimize anti-inflammatory effects in humans with chronic inflammation.
C1 [Ferguson, Jessica J. A.; Abbott, Kylie A.; Garg, Manohar L.] Univ Newcastle, Sch Biomed Sci & Pharm, Nutraceut Res Program, Callaghan, NSW, Australia.
C3 University of Newcastle
RP Garg, ML (corresponding author), Univ Newcastle, Nutraceut Res Program, 305C Med Sci Bldg, Callaghan, NSW 2308, Australia.
EM Manohar.Garg@newcastle.edu.au
RI Garg, Manohar/A-5795-2009; Ferguson, Jessica/ABC-2840-2021
OI Garg, Manohar/0000-0003-0514-0865; Ferguson, Jessica/0000-0002-7962-1840
FU Advanced Nutrition Unit at Sanitarium Health & Wellbeing Company
FX This work was partially supported by a contribution from the Advanced
   Nutrition Unit at Sanitarium Health & Wellbeing Company, which had no
   input in the conduct, analysis, or reporting of this study.
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NR 76
TC 59
Z9 63
U1 3
U2 24
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0029-6643
EI 1753-4887
J9 NUTR REV
JI Nutr. Rev.
PD SEP
PY 2021
VL 79
IS 9
BP 1043
EP 1066
DI 10.1093/nutrit/nuaa114
PG 24
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA XT8ES
UT WOS:000733814500006
PM 34378053
DA 2025-06-11
ER

PT J
AU Osterholm, EA
   Hostinar, CE
   Gunnar, MR
AF Osterholm, Erin A.
   Hostinar, Camelia E.
   Gunnar, Megan R.
TI Alterations in stress responses of the hypothalamic-pituitary-adrenal
   axis in small for gestational age infants
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE Hypothalamic-pituitary-adrenal (HPA) axis; Intrauterine adversity;
   Newborn; Developmental programming; Cortisol
ID LOW-BIRTH-WEIGHT; SALIVARY CORTISOL; ADULT LIFE; PLASMA; BORN; SIZE; SEX
AB Mounting epidemiologic evidence and animal models suggest that stressful conditions during the intrauterine period may increase susceptibility to several adult conditions, including metabolic syndrome, cardiovascular disease, and psychiatric disorders. Increased cortisol levels due to alterations in the regulation of the hypothalamic-pituitary-adrenal (HPA) axis are believed to be one mediating mechanism. Infants born after significant exposure to stressful conditions are often small for gestational age (SGA) based on standardized growth norms. Lifelong programming of the HPA axis has been proposed as a mechanism to explain the association between SGA infants and adult disease. However, few studies have measured HPA axis function proximal to birth as done in this study of SGA infants during the first week of life. Participants included 37 infants in two groups based on birth size (gestational age range: 34-41 weeks). SGA infants were <10th percentile for age (n = 21) and appropriate for gestational age (AGA) infants (n = 16) were from 20 to 90th percentile for age. Cortisol response to a heel lance for blood collection was measured for all infants. Hierarchical Linear Modeling was used to test the effect of AGA/SGA group status on cortisol trajectories in response to the stressor. Group was a significant predictor of quadratic slopes (t = 2.84, chi(2) = 8.19, p = .004) after controlling for the effect of group on intercepts and linear slopes. Predicted growth curves for In-cortisol were plotted for each group based on regression coefficients. The predicted curves capture the significant group difference in trajectories, as well as the blunted response for the SGA group and the robust peak in cortisol production in response to the stressor for the AGA group. This evidence suggests SGA neonates have blunted HPA axis responses to stressors in comparison to AGA infants. These findings are consistent with animal models showing that adverse intrauterine conditions can result in blunted cortisol responses to acute stressors and may provide a mechanism for adult susceptibility to disease for individuals that are SGA at birth. (C) 2012 Elsevier Ltd. All rights reserved.
C1 [Osterholm, Erin A.] Univ Minnesota, Dept Pediat, Div Neonatol, Minneapolis, MN 55406 USA.
   [Hostinar, Camelia E.; Gunnar, Megan R.] Univ Minnesota, Inst Child Dev, Minneapolis, MN 55406 USA.
C3 University of Minnesota System; University of Minnesota Twin Cities;
   University of Minnesota System; University of Minnesota Twin Cities
RP Osterholm, EA (corresponding author), Univ Minnesota, Dept Pediat, Div Neonatol, 2450 Riverside Ave,MB 630, Minneapolis, MN 55406 USA.
EM oste0123@umn.edu
FU Med-Immune(R) for follow-up care of the preterm infant
FX This project was financed by a fellowship grant from Med-Immune (R) for
   follow-up care of the preterm infant. The funding sources had no role in
   study design; in the collection, analysis, and interpretation of the
   data; in the writing of the manuscript; and in the decision to submit
   the paper for publication.
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NR 29
TC 33
Z9 36
U1 0
U2 8
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD OCT
PY 2012
VL 37
IS 10
BP 1719
EP 1725
DI 10.1016/j.psyneuen.2012.03.005
PG 7
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA 010MA
UT WOS:000309097300012
PM 22480998
DA 2025-06-11
ER

PT J
AU Tarantino, G
   Conca, P
   Coppola, A
   Vecchione, R
   Di Minno, G
AF Tarantino, G.
   Conca, P.
   Coppola, A.
   Vecchione, R.
   Di Minno, G.
TI Serum concentrations of the tissue polypeptide specific antigen in
   patients suffering from non-alcoholic steatohepatitis
SO EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
LA English
DT Article; Proceedings Paper
CT Digestive Disease Week Meeting/105th Annual Meeting of the
   American-Gastroenterological-Association
CY MAY 16-20, 2004
CL New Orleans, LA
SP Amer Gastroenterol Assoc
DE alanine aminotransferase; metabolic syndrome; non-alcoholic fatty liver
   disease; non-alcoholic steatohepatitis; tissue polypeptide specific
   antigen; ultrasonography
ID FATTY LIVER-DISEASE; HOMEOSTASIS MODEL ASSESSMENT; TUMOR-MARKERS;
   CYTOKERATINS; EXPRESSION; APOPTOSIS; KERATIN; TPS; CYFRA-21-1; GLUCOSE
AB Background: Liver histology is the gold standard for diagnosis of non-alcoholic fatty liver disease. Ethical considerations and patient choice often preclude performing a liver biopsy, especially considering the rare but potential risk. Searching for a good serological marker substitute for the invasive procedure was the aim of our study. Keratins, mainly 8 and 18, play not only a mere structural role providing mechanical stability to hepatocytes, but also represent a target via toxic stress ultimately inducing apoptosis/necrosis. Tissue polypeptide-specific antigen (TPS), a serological mirror of keratin 18, is widely used as a marker for various cancers. This antigen was assessed in three different groups who were overweight or obese.
   Materials and methods: In this cross-sectional case-control study, 48 cancer-free patients with non-alcoholic steatohepatitis (NASH, Group 1), 48 patients with pure fatty liver (FL, Group 2), and 47 volunteers (Group 3) were studied. All of them were referred to our metabolic unit for routine evaluation.
   Results: The median (range) TPS levels were 123 (56-286) ng mL(-1) in NASH patients. FL patients and volunteers had significantly lower TPS levels, 76 (38-98) ng mL(-1) and 64 (28-87) ng mL(-1), respectively (P = 0.0001). A value of 88 ng mL(-1) in patients with underlying bright liver was associated with a high probability of NASH (sensitivity and specificity = 92% and 96%, respectively). One patient (2.1%) with FL had a TPS value > 88 ng mL(-1), but in the same group, 29 FL patients (60.4%) had an alanine aminotransferase value > 40 U L-1. Based on a recent classification of liver fibrosis, the median (range) TPS values were significantly different among the stages: F1 (n = 23) = 100 (76-264) ng mL(-1); F2 (n = 21) = 134 (56-276) ng mL(-1); and F3 (n = 4) = 199.5 (123-286) ng mL(-1), respectively (P = 0.014).
   Conclusions: Our study shows that TPS is a better marker than alanine aminotransferase activity, ultrasonography or the combination of both parameters in differentiating NASH from FL.
C1 Univ Naples Federico II, Fac Med & Chirurg, Dipartimento Med Clin & Sperimentale, I-80131 Naples, Italy.
   Univ Naples Federico II, Sch Med, Dept Clin & Expt Med, I-80131 Naples, Italy.
   Univ Naples Federico II, Sch Med, Inst Pathol, I-80131 Naples, Italy.
C3 University of Naples Federico II; University of Naples Federico II;
   University of Naples Federico II
RP Tarantino, G (corresponding author), Univ Naples Federico II, Fac Med & Chirurg, Dipartimento Med Clin & Sperimentale, Via Sergio Pansini 5, I-80131 Naples, Italy.
EM tarantin@unina.it
RI Tarantino, Giovanni/AAW-2007-2021; Coppola, Antonio/J-1846-2012
OI Di Minno, Giovanni/0000-0003-4235-7166; Coppola,
   Antonio/0000-0003-3697-706X
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NR 29
TC 38
Z9 41
U1 0
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0014-2972
EI 1365-2362
J9 EUR J CLIN INVEST
JI Eur. J. Clin. Invest.
PD JAN
PY 2007
VL 37
IS 1
BP 48
EP 53
DI 10.1111/j.1365-2362.2007.01745.x
PG 6
WC Medicine, General & Internal; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC General & Internal Medicine; Research & Experimental Medicine
GA 114HQ
UT WOS:000242657700007
PM 17181567
DA 2025-06-11
ER

PT J
AU Hu, XF
   Loan, A
   Chan, HM
AF Hu, Xue Feng
   Loan, Allison
   Chan, Hing Man
TI Re-thinking the link between exposure to mercury and blood pressure
SO ARCHIVES OF TOXICOLOGY
LA English
DT Review
DE Mercury; Hypertension; Mechanism; Animal studies; Epidemiology;
   Narrative review
ID CARDIAC AUTONOMIC ACTIVITY; PRENATAL METHYLMERCURY EXPOSURE; INORGANIC
   MERCURY; METABOLIC SYNDROME; METHYL MERCURY; OXIDATIVE STRESS;
   ENDOTHELIAL DYSFUNCTION; CARDIOVASCULAR-DISEASE; NATIONAL-HEALTH;
   NITRIC-OXIDE
AB Hypertension or high blood pressure (BP) is a prevalent and manageable chronic condition which is a significant contributor to the total global disease burden. Environmental chemicals, including mercury (Hg), may contribute to hypertension onset and development. Hg is a global health concern, listed by the World Health Organization (WHO) as a top ten chemical of public health concern. Most people are exposed to some level of Hg, with vulnerable groups, including Indigenous peoples and small-scale gold miners, at a higher risk for exposure. We published a systematic review and meta-analysis in 2018 showing a dose-response relationship between Hg exposure and hypertension. This critical review summarizes the biological effects of Hg (both organic and inorganic form) on the underlying mechanisms that may facilitate the onset and development of hypertension and related health outcomes and updates the association between Hg exposure (total Hg concentrations in hair) and BP outcomes. We also evaluated the weight of evidence using the Bradford Hill criteria. There is a strong dose-response relationship between Hg (both organic and inorganic) exposure and BP in animal studies and convincing evidence that Hg contributes to hypertension by causing structural and functional changes, vascular reactivity, vasoconstriction, atherosclerosis, dyslipidemia, and thrombosis. The underlying mechanisms are vast and include impairments in antioxidant defense mechanisms, increased ROS production, endothelial dysfunction, and alteration of the renin-angiotensin system. We found additional 16 recent epidemiological studies that have reported the relationship between Hg exposure and hypertension in the last 5 years. Strong evidence from epidemiological studies shows a positive association between Hg exposure and the risk of hypertension and elevated BP. The association is mixed at lower exposure levels but suggests that Hg can affect BP even at low doses when co-exposed with other metals. Further research is needed to develop robust conversion factors among different biomarkers and standardized measures of Hg exposure. Regulatory agencies should consider adopting a 2 mu g/g hair Hg level as a cut-off for public health regulation, especially for adults older than child-bearing age.
C1 [Hu, Xue Feng; Loan, Allison; Chan, Hing Man] Univ Ottawa, Dept Biol, Chem & Environm Toxicol Program, 30 Marie Curie, Ottawa, ON K1N 6N5, Canada.
C3 University of Ottawa
RP Chan, HM (corresponding author), Univ Ottawa, Dept Biol, Chem & Environm Toxicol Program, 30 Marie Curie, Ottawa, ON K1N 6N5, Canada.
EM laurie.chan@uottawa.ca
RI Chan, Laurie/C-4055-2014
OI Chan, Laurie/0000-0003-4351-7483
FU Canada Research Chairs; Canada Research Chair Program (CRC); Natural
   Science and Engineering Research Council of Canada (NSERC); NSERC
FX H.M.C. received findings from the Canada Research Chair Program (CRC)
   and a Discovery Grant from the Natural Science and Engineering Research
   Council of Canada (NSERC). CRC and NSERC have no role in the design,
   analysis, or writing of this article.
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   TOXICOL MECH METHOD
NR 222
TC 0
Z9 0
U1 5
U2 5
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0340-5761
EI 1432-0738
J9 ARCH TOXICOL
JI Arch. Toxicol.
PD FEB
PY 2025
VL 99
IS 2
BP 481
EP 512
DI 10.1007/s00204-024-03919-8
EA JAN 2025
PG 32
WC Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Toxicology
GA T9M7O
UT WOS:001395451900001
PM 39804370
OA hybrid, Green Accepted
DA 2025-06-11
ER

PT J
AU Kazibwe, R
   Singleton, MJ
   Ahmad, MI
   Kaze, AD
   Chevli, PA
   Namutebi, JH
   Kasozi, RN
   Asiimwe, DD
   Kazibwe, J
   Shapiro, MD
   Yeboah, J
AF Kazibwe, Richard
   Singleton, Matthew J.
   Ahmad, Muhammad Imtiaz
   Kaze, Arnaud D.
   Chevli, Parag A.
   Namutebi, Juliana H.
   Kasozi, Ramla N.
   Asiimwe, Denis D.
   Kazibwe, Joseph
   Shapiro, Michael D.
   Yeboah, Joseph
TI Association between weight variability, weight change and clinical
   outcomes in hypertension
SO AMERICAN JOURNAL OF PREVENTIVE CARDIOLOGY
LA English
DT Article
DE Weight variability; Weight change; Hypertension; Clinical outcomes
ID BODY-MASS INDEX; METABOLIC SYNDROME; BLOOD-PRESSURE; OLDER-ADULTS;
   RISK-FACTOR; FLUCTUATIONS; MORTALITY; OBESITY; DISEASE; HEALTH
AB Objective: The effect of body weight variability (BWV) and body weight change (BWC) in high-risk individuals with hypertension, but without diabetes mellitus (DM) remains unclear. We examined the effect of BWV and BWC on the primary outcome [the composite of myocardial infarction (MI), other acute coronary syndromes, stroke, acute decompensated heart failure (HF), or cardiovascular (CV) death] and all-cause mortality in the Systolic Blood Pressure Intervention Trial (SPRINT).Methods: In this post-hoc analysis, we used multivariate Cox regression models to examine the risk associated with BWV and BWC for the primary outcome in SPRINT. BWV was defined as the intra-individual average successive variability (ASV). BWC was defined as baseline weight minus final weight.Results: A total of 8714 SPRINT participants (mean age 67.8 +/- 9.4 years, 35.1 % women, 58.9 % Whites) with available data on body weight were included. The median follow-up was about 3.9 years (IQR, 3.3-4.4). In multivariable-adjusted Cox models, each 1 unit standard deviation (SD) of BWV was significantly associated with a higher risk for the primary outcome, all-cause mortality, HF, MI, and stroke [HR(95 % CI)]: 1.13 (1.07-1.19; p < 0.0001), 1.22 (1.14-1.30; p < 0.0001), 1.16 (1.07-1.26; p < 0.001), 1.10 (1.00-1.20; p = 0.047), and 1.15 (1.05-1.27; p = 0.005), respectively. Similarly, each 1 unit SD of BWC was significantly associated with a higher risk of the primary outcome, all-cause mortality, MI, and HF: 1.11(1.02-1.21; p = 0.017), 1.44 (1.26-1.65; p < 0.0001), 1.16 (1.01-1.32; p = 0.041) and 1.19 (1.02-1.40; p = 0.031) respectively. However, there was no significant association with CV death (for both BWV and BWC) or stroke (BWC).Conclusion: In high-risk hypertension, BWV and BWC were both associated with higher risk of the primary outcome and all-cause mortality. These results further stress the clinical importance of sustained weight loss and minimizing fluctuations in weight in hypertension.
C1 [Kazibwe, Richard; Chevli, Parag A.] Wake Forest Univ, Sch Med, Sect Hosp Med, Dept Med, Winston Salem, NC USA.
   [Singleton, Matthew J.] WellSpan Hlth, Sect Cardiovasc Med, Dept Med, York, PA USA.
   [Ahmad, Muhammad Imtiaz] Med Coll Wisconsin, Sect Hosp Med, Dept Internal Med, Wauwatosa, WI USA.
   [Kaze, Arnaud D.] Sovah Hlth, Dept Med, Danville, VA USA.
   [Namutebi, Juliana H.] Wake Forest Univ, Sch Grad Studies, Winston Salem, NC USA.
   [Kasozi, Ramla N.] Mayo Clin, Dept Family Med, Jacksonville, FL USA.
   [Asiimwe, Denis D.] Univ Florida, Dept Med, Gainesville, FL USA.
   [Kazibwe, Joseph] Sheffield Teaching Hosp, Dept Cardiol, Sheffield, England.
   [Shapiro, Michael D.] Wake Forest Univ, Sch Med, Ctr Prevent Cardiovasc Dis, Sect Cardiovasc Med, Winston Salem, NC USA.
   [Yeboah, Joseph] Wake Forest Univ, Sch Med, Dept Med, Sect Cardiovasc Med, Winston Salem, NC USA.
   [Kazibwe, Richard] Wake Forest Univ, Sch Med, Med Ctr Blvd, Winston Salem, NC 27157 USA.
C3 Wake Forest University; Medical College of Wisconsin; Wake Forest
   University; Mayo Clinic; State University System of Florida; University
   of Florida; University of Sheffield; Wake Forest University; Wake Forest
   University; Wake Forest University
RP Kazibwe, R (corresponding author), Wake Forest Univ, Sch Med, Med Ctr Blvd, Winston Salem, NC 27157 USA.
EM rkazibwe@wakehealth.edu
RI CHEVLI, PARAG/W-3133-2019
OI Kazibwe, Richard/0000-0001-7085-3373; Kasozi, Ramla/0000-0001-9621-1619
FU National Institutes of Health (NIH); National Heart, Lung, and Blood
   Institute (NHLBI); National Institute of Diabetes and Digestive and
   Kidney Diseases (NIDDK); National Institute of Neurological Disorders
   and Stroke (NINDS) [HHSN268200900040C, HHSN268200900046C, HHSN2682009000
   47C, HHSN268200900048C, HHSN268200900049C, A-HL-13-002-001]; National
   Institute on Aging (NIA)
FX The Systolic Blood Pressure Intervention Trial was funded with Federal
   funds from the National Institutes of Health (NIH), including the
   National Heart, Lung, and Blood Institute (NHLBI), the National
   Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), the
   National Institute on Aging (NIA), and the National Institute of
   Neurological Disorders and Stroke (NINDS), under Contract Numbers
   HHSN268200900040C, HHSN268200900046C, HHSN2682009000 47C,
   HHSN268200900048C, HHSN268200900049C, and Inter-Agency Agreement Number
   A-HL-13-002-001. This post hoc analysis was unfunded.
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NR 28
TC 2
Z9 2
U1 0
U2 2
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2666-6677
J9 AM J PREVENT CARDIOL
JI American J. Preventive Cardiology
PD DEC
PY 2023
VL 16
AR 100610
DI 10.1016/j.ajpc.2023.100610
EA OCT 2023
PG 7
WC Cardiac & Cardiovascular Systems
WE Emerging Sources Citation Index (ESCI)
SC Cardiovascular System & Cardiology
GA Y5PN7
UT WOS:001105776100001
PM 37942025
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Cui, QW
   Zhu, X
   Guan, GC
   Hui, RT
   Zhu, L
   Wang, JK
AF Cui, Qianwei
   Zhu, Xu
   Guan, Gongchang
   Hui, Rutai
   Zhu, Ling
   Wang, Junkui
TI Association of N,N-diethyl-m-toluamide (DEET) with obesity among adult
   participants: Results from NHANES 2007-2016
SO CHEMOSPHERE
LA English
DT Article
DE DEET; Obesity; Abdominal obesity; NHANES; Epidemiology
ID OXIDATIVE STRESS; ABDOMINAL OBESITY; INSECT REPELLENT; PYRIDOSTIGMINE
   BROMIDE; CARDIOVASCULAR-DISEASE; WAIST CIRCUMFERENCE; DERMAL
   APPLICATION; METABOLIC SYNDROME; NATIONAL-HEALTH; EXPOSURE
AB Background: The purpose of this study was to examine the relationship between N,N-diethyl-m-toluamide (DEET) exposure and obesity-related outcomes in the general adult population using the data from the National Health and Nutrition Examination Survey (NHANES). Methods: This cross-sectional study examined the data from the NHANES from 2007 to 2016 and totally evaluated 8,770 individuals. DEET's primary oxidative metabolite, 3-(diethylcarbamoyl) benzoic acid (DCBA), is a sensitive and specific indicator of DEET exposure. DCBA was divided into three groups based on the interquartile range. Body mass index (BMI) and waist circumference (WC) were used to define obesity and abdominal obesity, respectively. The association among DCBA and obesity-related outcomes was evaluated using a multivariable linear and logistic regression model. Results: Overall, median age of participants was 46.0 (IQR 31.0, 59.0) years, with 4295 (49.2%) men, while median BMI and WC were 27.8 (24.0, 32.0) and 29.6 (86.6, 108.1) kg/m(2), respectively. Approximately 3,251 (35.9%) cases of obesity and 4,778 cases (54.4%) of abdominal obesity were observed. In multivariable-adjusted linear regression models, as the tertiles of DCBA increased, BMI and WC monotonically increased regardless of the adjustments (allp for trend < 0.01). By referring the lowest tertile of DCBA, the highest tertile was associated with a higher BMI (beta = 0.83, 95% confidence intervals [CI] [0.45, 1.21]; p < 0.001) and WC (beta = 1.59, 95% CI [0.59, 2.60]; p = 0.002). The multivariate odds ratios (95% CI) for obesity increased monotonically as 1.18 (0.97-1.44) and 1.36 (1.15-1.61) (p for trend 0.001). Similar associations between DCBA and the prevalence of abdominal obesity were observed across increasing DCBA tertiles compared with the reference tertile (OR = 1.22, 95% CI [1.02, 1.44]; OR = 1.28, 95% CI [1.08-1.54]; p for trend = 0.002). Conclusions: These findings suggested that higher DCBA concentrations are positively associated with the prevalence of obesity and abdominal obesity in the general adult population.
C1 [Cui, Qianwei; Guan, Gongchang; Zhu, Ling; Wang, Junkui] Shaanxi Prov Peoples Hosp, Dept Cardiol, Xian 710000, Shaanxi, Peoples R China.
   [Zhu, Xu] Nanjing Med Univ, Jiangsu Prov Hosp, Dept Cardiol, Affiliated Hosp 1, Nanjing 210000, Jiangsu, Peoples R China.
   [Hui, Rutai] Chinese Acad Med Sci & Peking Union Med Coll, Fuwai Hosp, Natl Ctr Cardiovasc Dis, Dept Cardiol,State Key Lab Cardiovasc Dis, Beijing 100037, Peoples R China.
   [Zhu, Ling; Wang, Junkui] Xi An Jiao Tong Univ, Dept Cardiol, Affiliated Hosp 3, Xian 710000, Shaanxi, Peoples R China.
   [Zhu, Ling; Wang, Junkui] Shaanxi Prov Peoples Hosp, Dept Cardiol, 256 youyi West Rd, Xian 710000, Shaanxi, Peoples R China.
C3 Xi'an Medical University; Nanjing Medical University; Chinese Academy of
   Medical Sciences - Peking Union Medical College; Fu Wai Hospital - CAMS;
   Peking Union Medical College; Xi'an Jiaotong University; Xi'an Medical
   University
RP Zhu, L; Wang, JK (corresponding author), Shaanxi Prov Peoples Hosp, Dept Cardiol, 256 youyi West Rd, Xian 710000, Shaanxi, Peoples R China.
EM lingzhu2360@163.com; junkuiwang@yeah.net
RI Zhu, Ling/IUO-3706-2023; Zhu, Xu/IWE-0017-2023
OI Zhu, Xu/0000-0002-4347-3639; Zhu, Ling/0000-0002-6559-0967
FU Science and Technology Talents Support Program of Shaanxi Provincial
   People's Hospital [2021BJ- 10, 2021LJ-03]; Science and technology
   development incubation fund of Shaanxi Provincial People's Hospital
   [2020YXM-06, 2020YXM- 22]; Fundamental Research Funds for the Central
   Universities [xzy012019127]; Chinese Cardiovascular Association -Access
   fund [2019-CCA-ACCESS-052]
FX This work was supported by the Science and Technology Talents Support
   Program of Shaanxi Provincial People's Hospital (No. 2021BJ- 10, No.
   2021LJ-03) . Science and technology development incubation fund of
   Shaanxi Provincial People's Hospital (2020YXM-06, 2020YXM- 22) .
   Fundamental Research Funds for the Central Universities (No.
   xzy012019127) . Chinese Cardiovascular Association -Access fund (No.
   2019-CCA-ACCESS-052) .
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NR 66
TC 9
Z9 10
U1 2
U2 22
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0045-6535
EI 1879-1298
J9 CHEMOSPHERE
JI Chemosphere
PD NOV
PY 2022
VL 307
AR 135669
DI 10.1016/j.chemosphere.2022.135669
EA JUL 2022
PN 1
PG 8
WC Environmental Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology
GA 4Y9AZ
UT WOS:000861814500001
PM 35835239
DA 2025-06-11
ER

PT J
AU Gigante, E
   Picciocchi, E
   Valenzano, A
   Cibelli, G
   Ruberto, V
   Cantone, D
   Moretto, E
   Di Sarno, AD
   Longobardi, T
   Iennaco, D
   Messina, M
   Nascivera, N
   Pisanelli, D
   Polito, AN
   Marsala, G
   Costa, V
   Mosca, L
   Dell'Orco, S
AF Gigante, Elena
   Picciocchi, Elisabetta
   Valenzano, Anna
   Cibelli, Giuseppe
   Ruberto, Valentina
   Cantone, Daniela
   Moretto, Enrico
   Di Sarno, Alfonso Davide
   Longobardi, Teresa
   Iennaco, Daniela
   Messina, Martina
   Nascivera, Nicole
   Pisanelli, Daniela
   Polito, Anna Nunzia
   Marsala, Gabriella
   Costa, Vania
   Mosca, Luciana
   Dell'Orco, Sivia
TI THE EFFECTS OF THE ENDOCRINE DISRUPTORS AND OF THE HALOGENS ON THE
   FEMALE REPRODUCTIVE SYSTEM AND ON EPIGENETICS: A BRIEF REVIEW
SO ACTA MEDICA MEDITERRANEA
LA English
DT Review
DE Bisphenol A; embryonic development; endocrine disruptors; epigenetic;
   female reproductive system; halogens; Metal; Polybrominated Diphenyl
   Ethers; Phthalates; Pesticide
ID BISPHENOL-A; POLYCHLORINATED-BIPHENYLS; HYPERTHERMIC REACTIONS;
   INHIBITOR DEVELOPMENT; CHILDHOOD MIGRAINE; CEREBRAL INJECTION; OXIDATIVE
   STRESS; ITALIAN PATIENTS; EXPOSURE; CHILDREN
AB Introduction: An endocrine-disrupting chemical (EDC) is defined as "an exogenous chemical or a mixture of chemicals that interfere with any aspect of the hormonal action". Endocrine systems are a physiological interface with the environment and genetic-environmental interactions are disrupted by EDCs. Today, there are almost 1000 chemicals reported to have endocrine effects: the prevalence of EDC in our environment and in our bodies represents a major global health challenge. This review gathers the studies that have investigated the correlations between exposure to EDC and pathologies of the female reproductive system and fetal development.
   Methods: A PubMed research was conducted using the keywords, their variants, and their combinations (BPA, DES, MXC, pesticides, phthalates, plasticizers, PCBs, dioxins, ovaries, oocytes, ovaries, fallopian tubes, follicles, vagina, uterus, fibroids, fertility, infertility, puberty, polycystic ovary syndrome, premature ovarian failure, birth, preterm birth, birth outcome, steroid, hormone, female, girl and menopause).
   Results: The endocrine system plays a central role in all vertebrates and regulates critical biological functions such as metabolism, development, reproduction, and behavior. Epidemiological studies link EDCs with reproductive effects, neuro-behavioral and neurodevelopment alterations, metabolic syndrome, bone disorders, immune disorders, and cancers in humans. Human investigations confirm the results of the studies carried out on animal showing associations with many additional effects on health, including asthma, learning and behavior problems, premature puberty, infertility, breast and prostate cancer, Parkinson's disease, obesity and other diseases.
   Conclusions: It is important to undertake research with follow-up methodologies and/or longitudinal studies to detect the extent of exposure of pregnant women to EDCs and halogenated substances and the effects of such exposure on brain development. A future research hypothesis may consider the effect that these substances have on neuro-development and, more specifically, how EDCs are involved in pathogenic disorders such as autism spectrum disorders (ASD). In addition, a scientific study could be performed on the correlations between this type of substance and the inconveniences found in the field of executive frontal functions.
C1 [Gigante, Elena; Moretto, Enrico; Di Sarno, Alfonso Davide; Longobardi, Teresa; Iennaco, Daniela; Messina, Martina; Nascivera, Nicole; Costa, Vania; Mosca, Luciana; Dell'Orco, Sivia] SiPGI Postgrad Sch Integrated Gestalt Psychothera, DM 12-10-2007,Via V Veneto 240, I-80058 Naples, Italy.
   [Picciocchi, Elisabetta; Valenzano, Anna; Cibelli, Giuseppe; Ruberto, Valentina; Pisanelli, Daniela] Univ Foggia, Dept Clin & Expt Med, Foggia, Italy.
   [Picciocchi, Elisabetta] Casa Cura Villa dei Fiori Acerra, Naples, Italy.
   [Cantone, Daniela] Univ Campania Luigi Vanvitelli, Dept Psychol, Naples, Italy.
   [Polito, Anna Nunzia] Osped Riuniti Foggia, Complex Struct Neuropsychiat Childhood Adolescenc, Foggia, Italy.
   [Marsala, Gabriella] Osped Riuniti Foggia, Azienda Osped Univ, Foggia, Italy.
C3 University of Foggia; Universita della Campania Vanvitelli
RP Gigante, E (corresponding author), SiPGI Postgrad Sch Integrated Gestalt Psychothera, DM 12-10-2007,Via V Veneto 240, I-80058 Naples, Italy.
EM gigantelena@gmail.com
RI Mosca, Lucia/LUY-0201-2024; Moretto, Enrico/AFV-4935-2022; Di Sarno,
   Davide/JLL-2161-2023; Cibelli, Giuseppe/AAC-2635-2019
OI MOSCA, LUCIA LUCIANA/0000-0001-9090-094X; CIBELLI,
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PU CARBONE EDITORE
PI PALERMO
PA VIA QUINTINO SELLA, 68, PALERMO, 90139, ITALY
SN 0393-6384
EI 2283-9720
J9 ACTA MEDICA MEDITERR
JI Acta Medica Mediterr.
PY 2018
VL 34
IS 5
BP 1295
EP 1303
DI 10.19193/0393-6384_2018_5_199
PG 9
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA GL3JV
UT WOS:000437030700021
DA 2025-06-11
ER

PT J
AU Scheller, EL
   Khoury, B
   Moller, KL
   Wee, NKY
   Khandaker, S
   Kozloff, KM
   Abrishami, SH
   Zamarron, BF
   Singer, K
AF Scheller, Erica L.
   Khoury, Basma
   Moller, Kayla L.
   Wee, Natalie K. Y.
   Khandaker, Shaima
   Kozloff, Kenneth M.
   Abrishami, Simin H.
   Zamarron, Brian F.
   Singer, Kanakadurga
TI Changes in Skeletal Integrity and Marrow Adiposity during High-Fat Diet
   and after Weight Loss
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Article
DE obesity; bone; marrow adipose tissue; marrow fat; weight loss; leptin;
   high-fat diet; fracture
ID BONE-MINERAL DENSITY; SYMPATHETIC-NERVOUS-SYSTEM; BODY-MASS INDEX;
   INDUCED OBESITY; METABOLIC SYNDROME; OXIDATIVE STRESS; CANCELLOUS BONE;
   CORTICAL BONE; MOUSE MODEL; POSTMENOPAUSAL WOMEN
AB The prevalence of obesity has continued to rise over the past three decades leading to significant increases in obesity-related medical care costs from metabolic and non metabolic sequelae. It is now clear that expansion of body fat leads to an increase in inflammation with systemic effects on metabolism. In mouse models of diet-induced obesity, there is also an expansion of bone marrow adipocytes. However, the persistence of these changes after weight loss has not been well described. The objective of this study was to investigate the impact of high-fat diet (HFD) and subsequent weight loss on skeletal parameters in C57BI6/J mice. Male mice were given a normal chow diet (ND) or 60% HFD at 6 weeks of age for 12, 16, or 20 weeks. A third group of mice was put on HFD for 12 weeks and then on ND for 8 weeks to mimic weight loss. After these dietary challenges, the tibia and femur were removed and analyzed by micro computed-tomography for bone morphology. Decalcification followed by osmium staining was used to assess bone marrow adiposity, and mechanical testing was performed to assess bone strength. After 12, 16, or 20 weeks of HFD, mice had significant weight gain relative to controls. Body mass returned to normal after weight loss. Marrow adipose tissue (MAT) volume in the tibia increased after 16 weeks of HFD and persisted in the 20-week HFD group. Weight loss prevented HFD-induced MAT expansion. Trabecular bone volume fraction, mineral content, and number were decreased after 12, 16, or 20 weeks of HFD, relative to ND controls, with only partial recovery after weight loss. Mechanical testing demonstrated decreased fracture resistance after 20 weeks of HFD. Loss of mechanical integrity did not recover after weight loss. Our study demonstrates that HFD causes long-term, persistent changes in bone quality, despite prevention of marrow adipose tissue accumulation, as demonstrated through changes in bone morphology and mechanical strength in a mouse model of diet-induced obesity and weight loss.
C1 [Scheller, Erica L.; Moller, Kayla L.] Washington Univ, Dept Med, Div Bone & Mineral Dis, St Louis, MO 63130 USA.
   [Scheller, Erica L.; Khandaker, Shaima] Univ Michigan, Dept Mol & Integrat Physiol, Ann Arbor, MI 48109 USA.
   [Khoury, Basma; Kozloff, Kenneth M.] Univ Michigan, Dept Orthopaed Surg, Ann Arbor, MI 48109 USA.
   [Wee, Natalie K. Y.] Garvan Inst Med Res, Osteoporosis & Bone Biol Div, Sydney, NSW, Australia.
   [Abrishami, Simin H.] Univ Michigan, Sch Med, Dept Pediat & Communicable Dis, Div Pediat Endocrinol, Ann Arbor, MI USA.
   [Zamarron, Brian F.; Singer, Kanakadurga] Univ Michigan, Grad Program Immunol, Ann Arbor, MI 48109 USA.
C3 Washington University (WUSTL); University of Michigan System; University
   of Michigan; University of Michigan System; University of Michigan;
   Garvan Institute of Medical Research; University of Michigan System;
   University of Michigan; University of Michigan System; University of
   Michigan
RP Scheller, EL (corresponding author), Washington Univ, Dept Med, Div Bone & Mineral Dis, St Louis, MO 63130 USA.; Scheller, EL (corresponding author), Univ Michigan, Dept Mol & Integrat Physiol, Ann Arbor, MI 48109 USA.
EM scheller@wustl.edu
RI Wee, Natalie/AAF-2134-2019; Khandaker, Shaima/JLL-0462-2023; Scheller,
   Erica/H-6993-2019
OI Singer, Kanakadurga/0000-0001-8278-3800; Wee,
   Natalie/0000-0002-7314-2646; Zamarron, Brian/0000-0001-6549-4230;
   Scheller, Erica/0000-0002-1551-3816; Khandaker,
   Shaima/0000-0003-4855-358X
FU National Institute of Health [K99-DE024178, R00-DE024178, K08-DK101755];
   National Institute of Diabetes and Digestive and Kidney Diseases
   [P30DK020572, T32DK094775] Funding Source: NIH RePORTER
FX This work was supported by grants from the National Institute of Health,
   K99-DE024178 and R00-DE024178 (ES) and K08-DK101755 (KS).
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NR 65
TC 92
Z9 100
U1 0
U2 6
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD JUL 27
PY 2016
VL 7
AR 102
DI 10.3389/fendo.2016.00102
PG 13
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA DY7GR
UT WOS:000385298100001
PM 27512386
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Kelder, T
   Summer, G
   Caspers, M
   van Schothorst, EM
   Keijer, J
   Duivenvoorde, L
   Klaus, S
   Voigt, A
   Bohnert, L
   Pico, C
   Palou, A
   Bonet, ML
   Dembinska-Kiec, A
   Malczewska-Malec, M
   Kiec-Wilk, B
   del Bas, JM
   Caimari, A
   Arola, L
   van Erk, M
   van Ommen, B
   Radonjic, M
AF Kelder, Thomas
   Summer, Georg
   Caspers, Martien
   van Schothorst, Evert M.
   Keijer, Jaap
   Duivenvoorde, Loes
   Klaus, Susanne
   Voigt, Anja
   Bohnert, Laura
   Pico, Catalina
   Palou, Andreu
   Luisa Bonet, M.
   Dembinska-Kiec, Aldona
   Malczewska-Malec, Malgorzata
   Kiec-Wilk, Beata
   del Bas, Josep M.
   Caimari, Antoni
   Arola, Lluis
   van Erk, Marjan
   van Ommen, Ben
   Radonjic, Marijana
TI White adipose tissue reference network: a knowledge resource for
   exploring health-relevant relations
SO GENES AND NUTRITION
LA English
DT Article
DE Network biology; Systems biology; Data integration; Adipose tissue;
   Nutrition; Drugs
ID HIGH-FAT; TRANSCRIPTION FACTOR; METABOLIC SYNDROME; GENE-EXPRESSION;
   SHORT-TERM; OBESITY; INTERVENTION; MEDICINE; PROTEIN; MODEL
AB Optimal health is maintained by interaction of multiple intrinsic and environmental factors at different levels of complexity-from molecular, to physiological, to social. Understanding and quantification of these interactions will aid design of successful health interventions. We introduce the reference network concept as a platform for multi-level exploration of biological relations relevant for metabolic health, by integration and mining of biological interactions derived from public resources and context-specific experimental data. A White Adipose Tissue Health Reference Network (WATRefNet) was constructed as a resource for discovery and prioritization of mechanism-based biomarkers for white adipose tissue (WAT) health status and the effect of food and drug compounds on WAT health status. The WATRefNet (6,797 nodes and 32,171 edges) is based on (1) experimental data obtained from 10 studies addressing different adiposity states, (2) seven public knowledge bases of molecular interactions, (3) expert's definitions of five physiologically relevant processes key to WAT health, namely WAT expandability, Oxidative capacity, Metabolic state, Oxidative stress and Tissue inflammation, and (4) a collection of relevant biomarkers of these processes identified by BIOCLAIMS (http://bioclaims.uib.es). The WATRefNet comprehends multiple layers of biological complexity as it contains various types of nodes and edges that represent different biological levels and interactions. We have validated the reference network by showing overrepresentation with anti-obesity drug targets, pathology-associated genes and differentially expressed genes from an external disease model dataset. The resulting network has been used to extract subnetworks specific to the above-mentioned expert-defined physiological processes. Each of these process-specific signatures represents a mechanistically supported composite biomarker for assessing and quantifying the effect of interventions on a physiological aspect that determines WAT health status. Following this principle, five anti-diabetic drug interventions and one diet intervention were scored for the match of their expression signature to the five biomarker signatures derived from the WATRefNet. This confirmed previous observations of successful intervention by dietary lifestyle and revealed WAT-specific effects of drug interventions. The WATRefNet represents a sustainable knowledge resource for extraction of relevant relationships such as mechanisms of action, nutrient intervention targets and biomarkers and for assessment of health effects for support of health claims made on food products.
C1 [Kelder, Thomas; Summer, Georg; Caspers, Martien; van Erk, Marjan; van Ommen, Ben; Radonjic, Marijana] TNO, Microbiol & Syst Biol, NL-3700 AJ Zeist, Netherlands.
   [Summer, Georg] Maastricht Univ, CARIM, NL-6200 MD Maastricht, Netherlands.
   [van Schothorst, Evert M.; Keijer, Jaap; Duivenvoorde, Loes] Wageningen Univ, Human & Anim Physiol, NL-6700 AP Wageningen, Netherlands.
   [Klaus, Susanne; Voigt, Anja; Bohnert, Laura] German Inst Human Nutr Potsdam Rehbrucke, Grp Energy Metab, Nuthetal, Germany.
   [Pico, Catalina; Palou, Andreu; Luisa Bonet, M.] UIB, Mol Biol Nutr & Biotechnol Nutrigen, Palma De Mallorca, Spain.
   [Pico, Catalina; Palou, Andreu; Luisa Bonet, M.] CIBER Fisiopatol Obesidad & Nutr CIBEROBN, Palma De Mallorca, Spain.
   [Dembinska-Kiec, Aldona; Malczewska-Malec, Malgorzata] Jagiellonian Univ, Dept Clin Biochem, Coll Med, Krakow, Poland.
   [Kiec-Wilk, Beata] Jagiellonian Univ, Dept Metab Disorders, Coll Med, Krakow, Poland.
   [del Bas, Josep M.; Caimari, Antoni; Arola, Lluis] TECNIO, CTNS, Reus, Spain.
   [Arola, Lluis] Univ Rovira & Virgili, E-43007 Tarragona, Spain.
C3 Netherlands Organization Applied Science Research; Maastricht
   University; Maastricht University Medical Centre (MUMC); Wageningen
   University & Research; Leibniz Association; Deutsches Institut fur
   Ernahrungsforschung Potsdam-Rehbrucke (DIfE); Universitat de les Illes
   Balears; CIBER - Centro de Investigacion Biomedica en Red; CIBEROBN;
   Jagiellonian University; Collegium Medicum Jagiellonian University;
   Jagiellonian University; Collegium Medicum Jagiellonian University;
   Universitat Rovira i Virgili
RP Radonjic, M (corresponding author), EdgeLeap BV, Hooghiemstrapl 15, NL-3514 AX Utrecht, Netherlands.
EM marijana@edgeleap.com
RI Kelder, Thomas/B-8216-2008; del Bas, Josep/K-9310-2019; Palou,
   Andreu/K-9881-2014; Keijer, Jaap/J-8089-2013; Bonet,
   M.Luisa/H-6722-2015; Klaus, Susanne/P-9299-2018; Arola,
   Lluis/C-6074-2011; Pico, Catalina/H-7115-2015
OI Palou, Andreu/0000-0002-0295-4452; Keijer, Jaap/0000-0002-9720-7491;
   Bonet, M.Luisa/0000-0002-8698-0630; Klaus, Susanne/0000-0001-8726-185X;
   van Schothorst, Evert/0000-0002-3036-5903; del Bas, Josep
   Maria/0000-0002-0700-2004; Caimari, Antoni/0000-0001-6144-0294; Arola,
   Lluis/0000-0003-2767-1974; Pico, Catalina/0000-0001-6759-5844
FU European Union [244995]
FX We thank Francesc Puiggros for his contribution to definition of
   relevant physiological processes determining WAT health status, critical
   assessment of the manuscript and support of collaboration logistics from
   CTNS partner institute. The research leading to these results has
   received funding from the European Union's Seventh Framework Programme
   FP7 2007-2013 under grant agreement no 244995 (BIOCLAIMS Project).
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NR 72
TC 8
Z9 9
U1 0
U2 12
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1555-8932
EI 1865-3499
J9 GENES NUTR
JI Genes Nutr.
PD JAN
PY 2015
VL 10
IS 1
AR 439
DI 10.1007/s12263-014-0439-x
PG 18
WC Genetics & Heredity; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Genetics & Heredity; Nutrition & Dietetics
GA CD0HL
UT WOS:000350751300002
PM 25466819
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU He, ZX
   Sun, ZH
   Tan, ZL
   Tang, SX
   Zhou, CS
   Han, XF
   Wang, M
   Wu, DQ
   Kang, JH
   Beauchemin, KA
AF He, Z. X.
   Sun, Z. H.
   Tan, Z. L.
   Tang, S. X.
   Zhou, C. S.
   Han, X. F.
   Wang, M.
   Wu, D. Q.
   Kang, J. H.
   Beauchemin, K. A.
TI Effects of maternal protein or energy restriction during late gestation
   on antioxidant status of plasma and immune tissues in postnatal goats
SO JOURNAL OF ANIMAL SCIENCE
LA English
DT Article
DE antioxidant capacity; goat; maternal energy restriction; maternal
   protein restriction
ID INSULIN-PRODUCING CELLS; ENZYME GENE-EXPRESSION; OXIDATIVE STRESS;
   METABOLIC SYNDROME; RAT ISLETS; LIFE-SPAN; GROWTH; UNDERNUTRITION;
   VULNERABILITY; ADAPTATION
AB Maternal malnutrition can have temporary or long-lasting effects on development and physiological function of offspring. Our objective was to investigate whether maternal protein or energy restriction in late gestation affects the antioxidant status of plasma, immune organs (thymus and spleen), and natural barrier organs (jejunum) in neonatal goats and whether the effects could be reversed after nutritional recovery. Forty-five pregnant goats (Liuyang Blacks) of similar age (2.0 +/- 0.3 yr) and BW (22.2 +/- 1.5 kg at d 90 of gestation) were assigned to 3 dietary treatments during late gestation: control (ME = 9.34 MJ/kg and CP = 12.5%, DM basis), 40% protein restricted (PR), and 40% energy restricted (ER) until parturition, after which offspring received the normal diet for nutritional recovery. Plasma and tissues of kids were sampled to determine antioxidant enzymes [superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), total antioxidant capacity (T-AOC), and catalase (CAT)] and gene expression of antioxidant enzymes (Cu/Zn-SOD [SOD1], CAT, and peroxiredoxin 2 [PRDX2]). Maternal protein or energy restriction decreased (P < 0.05) SOD activities in plasma, liver, thymus, and spleen and SOD1 expression in thymus, and maternal energy restriction also decreased (P < 0.05) plasma GSH-Px activity and expressions of SOD1 and CAT in liver at birth. After nutritional recovery of 6 wk, SOD activities in thymus (both in PR and ER) and spleen (only in PR) were greater (P < 0.05), but CAT activity of thymus (both in PR and ER) and CAT expression (only in ER) were less (P < 0.01) than those in control. After nutritional recovery of 22 wk, SOD1 and PRDX2 expression in thymus (both in PR and ER) and SOD1 expression in liver (only in ER) were greater (P < 0.05) whereas CAT expression in thymus (both in PR and ER) was less (P < 0.001) than in control. The current results indicate that maternal protein or energy restriction can decrease the antioxidant capacity of the neonatal kids and result in an imbalance of SOD and hydrogen peroxide-inactivating systems in thymus, even after 6 or 22 wk of nutritional recovery.
C1 [He, Z. X.; Tan, Z. L.; Tang, S. X.; Zhou, C. S.; Han, X. F.; Wang, M.; Wu, D. Q.; Kang, J. H.] Chinese Acad Sci, Inst Subtrop Agr, Key Lab Agroecol Proc Subtrop Reg, Changsha 410125, Hunan, Peoples R China.
   [He, Z. X.; Wu, D. Q.] Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China.
   [Sun, Z. H.] Southwest Univ, Coll Anim Sci & Technol, Chongqing 400715, Peoples R China.
   [Beauchemin, K. A.] Agr & Agri Food Canada, Lethbridge Res Ctr, Lethbridge, AB T1J 4B1, Canada.
C3 Chinese Academy of Sciences; Institute of Subtropical Agriculture, CAS;
   Chinese Academy of Sciences; University of Chinese Academy of Sciences,
   CAS; Southwest University - China; Agriculture & Agri Food Canada
RP Tan, ZL (corresponding author), Chinese Acad Sci, Inst Subtrop Agr, Key Lab Agroecol Proc Subtrop Reg, Changsha 410125, Hunan, Peoples R China.
EM zltan@isa.ac.cn
RI Wu, Duanqin/GLR-0201-2022
OI He, Zhixiong/0000-0002-4802-3506
FU Chinese Academy of Sciences [KZCX2-YW-455]; CAS/SAFEA International
   Partnership Program for Creative Research Teams [KZCX2-YW-T07]; CAS
   Visiting Professorship for Senior International Scientists [2010T2S13]
FX This study was financially supported by the Chinese Academy of Sciences
   Grant No. KZCX2-YW-455, CAS/SAFEA International Partnership Program for
   Creative Research Teams Grant No. KZCX2-YW-T07, and CAS Visiting
   Professorship for Senior International Scientists Grant No. 2010T2S13.
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NR 44
TC 21
Z9 29
U1 0
U2 45
PU AMER SOC ANIMAL SCIENCE
PI CHAMPAIGN
PA PO BOX 7410, CHAMPAIGN, IL 61826-7410 USA
SN 0021-8812
EI 1525-3163
J9 J ANIM SCI
JI J. Anim. Sci.
PD DEC
PY 2012
VL 90
IS 12
BP 4319
EP 4326
DI 10.2527/jas.2012-5088
PG 8
WC Agriculture, Dairy & Animal Science
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture
GA 059XH
UT WOS:000312738400018
PM 22952363
DA 2025-06-11
ER

PT J
AU Derosa, G
   Cicero, AFG
   Fogari, E
   D'Angelo, A
   Bonaventura, A
   Maffioli, P
AF Derosa, Giuseppe
   Cicero, Arrigo F. G.
   Fogari, Elena
   D'Angelo, Angela
   Bonaventura, Aldo
   Maffioli, Pamela
TI Effects of n-3 PUFA on insulin resistance after an oral fat load
SO EUROPEAN JOURNAL OF LIPID SCIENCE AND TECHNOLOGY
LA English
DT Article
DE n-3 PUFA; Adiponectin; Insulin-resistance; Oral fat load; Resistin
ID MYOCARDIAL-INFARCTION; METABOLIC SYNDROME; OXIDATIVE STRESS;
   HEART-DISEASE; ACIDS; GLUCOSE; SUPPLEMENTATION; INFLAMMATION;
   METAANALYSIS; ASSOCIATION
AB The aim of this study was to evaluate the effects of omega-3 PUFA (n-3 PUFA) on lipid profile and insulin resistance biomarkers. Patients were assigned to receive placebo or n-3 PUFA 1 g three times a day, during the meals, for 6 months. We evaluated: body mass index (BMI), body weight, fasting plasma glucose (FPG), fasting plasma insulin (FPI), homeostasis model assessment insulin resistance index (HOMA-IR), blood pressure, lipid profile, resistin (r), retinol binding protein-4 (RBP-4), adiponectin (ADN), visfatin, and vaspin. Furthermore patients underwent an oral fat load (OFL) and an euglycemic hyperinsulinemic clamp to evaluate M value, and total glucose requirement (TGR). Triglycerides value obtained with n-3 PUFA was lower, while HDL-C, and ADN values were higher compared to placebo. After the OFL, and comparing the OFL performed at the baseline and at the end of the study, there was a decrease of triglycerides (Tg), resistin (r), and RBP-4 values, and an increase of ADN value with n-3 PUFA, but not with placebo. We conclude that the treatment with n-3 PUFA resulted in a greater improvement of lipid profile and ADN compared to placebo in a baseline condition, and an improvement of all insulin resistance parameters after an OFL.
   Practical applications: The inverse association between dietary intake of n-3 PUFA and cardiovascular disease morbidity/mortality was primarily established following the observation that the Greenland Inuits had low mortality from coronary heart disease despite a fat-rich diet. Our group has already shown that n-3 PUFA improved the lipid profile and the coagulation, fibrinolytic, and inflammatory parameters compared to placebo. We also observed that highly purified n-3 PUFA supplementation significantly reduced the blood pressure, pulse pressure, and basal heart rate in hypertriglyceridemic patients with normal-high blood pressure. The current study showed that treatment with n-3 PUFA not only improved lipid profile in a baseline situation, but it also improved all insulin resistance parameters in a post-prandial situation simulated with an OFL. This is another important action of the n-3 PUFA which can increase their utility in the clinical practice.
C1 [Derosa, Giuseppe; Cicero, Arrigo F. G.; Fogari, Elena; D'Angelo, Angela; Bonaventura, Aldo; Maffioli, Pamela] Univ Pavia, Dept Internal Med & Therapeut, I-27100 Pavia, Italy.
   [Derosa, Giuseppe] Univ Bologna, Dept Internal Med Aging & Kidney Dis, G Descovich Atherosclerosis Study Ctr, Bologna, Italy.
C3 University of Pavia; University of Bologna
RP Derosa, G (corresponding author), Univ Pavia, Dept Internal Med & Therapeut, Ple C Golgi 2, I-27100 Pavia, Italy.
EM giuseppe.derosa@unipv.it
RI Cicero, Arrigo/H-8244-2019; Bonaventura, Aldo/ABC-4051-2020; Derosa,
   Giuseppe/H-8571-2019; Bonaventura, Aldo/O-7712-2015; Derosa,
   Giuseppe/F-2615-2012; Maffioli, Pamela/E-9753-2012
OI Cicero, Arrigo Francesco Giuseppe/0000-0002-4367-3884; Bonaventura,
   Aldo/0000-0002-4747-5535; Fogari, Elena/0000-0002-9446-7546; Derosa,
   Giuseppe/0000-0003-3573-4760; Maffioli, Pamela/0000-0002-4285-6507;
   D'Angelo, Angela/0000-0003-3008-9264
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NR 51
TC 29
Z9 29
U1 0
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1438-7697
EI 1438-9312
J9 EUR J LIPID SCI TECH
JI Eur. J. Lipid Sci. Technol.
PD AUG
PY 2011
VL 113
IS 8
BP 950
EP 960
DI 10.1002/ejlt.201000504
PG 11
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA 818NV
UT WOS:000294760200002
DA 2025-06-11
ER

PT J
AU Hardwick, JP
   Osei-Hyiaman, D
   Wiland, H
   Abdelmegeed, MA
   Song, BJ
AF Hardwick, James P.
   Osei-Hyiaman, Douglas
   Wiland, Homer
   Abdelmegeed, Mohamed A.
   Song, Byoung-Joon
TI PPAR/RXR Regulation of Fatty Acid Metabolism and Fatty Acid
   ω-Hydroxylase (CYP4) Isozymes: Implications for Prevention of
   Lipotoxicity in Fatty Liver Disease
SO PPAR RESEARCH
LA English
DT Review
ID ACTIVATED-RECEPTOR-ALPHA; TRIGLYCERIDE TRANSFER PROTEIN; HEPATIC
   CYTOCHROME-P450 2E1; ELEMENT-BINDING PROTEIN; ACYL-COA OXIDASE;
   VERY-LONG-CHAIN; INSULIN-RESISTANCE; LIPID-METABOLISM;
   MOLECULAR-MECHANISMS; PEROXISOMAL PROLIFERATORS
AB Fatty liver disease is a common lipid metabolism disorder influenced by the combination of individual genetic makeup, drug exposure, and life-style choices that are frequently associated with metabolic syndrome, which encompasses obesity, dyslipidemia, hypertension, hypertriglyceridemia, and insulin resistant diabetes. Common to obesity related dyslipidemia is the excessive storage of hepatic fatty acids (steatosis), due to a decrease in mitochondria beta-oxidation with an increase in both peroxisomal beta-oxidation, and microsomal.-oxidation of fatty acids through peroxisome proliferator activated receptors (PPARs). How steatosis increases PPAR alpha activated gene expression of fatty acid transport proteins, peroxisomal and mitochondrial fatty acid beta-oxidation and omega-oxidation of fatty acids genes regardless of whether dietary fatty acids are polyunsaturated (PUFA), monounsaturated (MUFA), or saturated (SFA) may be determined by the interplay of PPARs and HNF4 alpha with the fatty acid transport proteins L-FABP and ACBP. In hepatic steatosis and steatohepatitis, the omega-oxidation cytochrome P450 CYP4A gene expression is increased even with reduced hepatic levels of PPARa. Although numerous studies have suggested the role ethanol-inducible CYP2E1 in contributing to increased oxidative stress, Cyp2e1-null mice still develop steatohepatitis with a dramatic increase in CYP4A gene expression. This strongly implies that CYP4A fatty acid.-hydroxylase P450s may play an important role in the development of steatohepatitis. In this review and tutorial, we briefly describe how fatty acids are partitioned by fatty acid transport proteins to either anabolic or catabolic pathways regulated by PPARs, and we explore how medium-chain fatty acid (MCFA) CYP4A and long-chain fatty acid (LCFA) CYP4F omega-hydroxylase genes are regulated in fatty liver. We finally propose a hypothesis that increased CYP4A expression with a decrease in CYP4F genes may promote the progression of steatosis to steatohepatitis. Copyright (C) 2009 James P. Hardwick et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
C1 [Hardwick, James P.; Wiland, Homer] NE OH Univ Coll Med & Pharm NEOUCOM NEOUCOP, Dept Integrat Med Sci, Rootstown, OH 44272 USA.
   [Osei-Hyiaman, Douglas] NIAAA, Lab Physiol Studies, NIH, Bethesda, MD 20892 USA.
   [Osei-Hyiaman, Douglas] Nippon Boehringer Ingelheim Co Ltd, CardioMetab Dis Res Grp, Dept Mol & Cellular Biol, Kobe Pharma Res Inst,Chuo Ku, Kobe, Hyogo 6500047, Japan.
   [Abdelmegeed, Mohamed A.; Song, Byoung-Joon] NIAAA, Lab Membrane Biochem & Biophys, NIH, Bethesda, MD 20892 USA.
C3 University System of Ohio; Northeast Ohio Medical University (NEOMED);
   National Institutes of Health (NIH) - USA; NIH National Institute on
   Alcohol Abuse & Alcoholism (NIAAA); Boehringer Ingelheim; National
   Institutes of Health (NIH) - USA; NIH National Institute on Alcohol
   Abuse & Alcoholism (NIAAA)
RP Hardwick, JP (corresponding author), NE OH Univ Coll Med & Pharm NEOUCOM NEOUCOP, Dept Integrat Med Sci, 4209 State Route 44, Rootstown, OH 44272 USA.
EM jph@neoucom.edu
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NR 152
TC 103
Z9 110
U1 3
U2 27
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1687-4757
EI 1687-4765
J9 PPAR RES
JI PPAR Res.
PY 2009
VL 2009
AR 952734
DI 10.1155/2009/952734
PG 20
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 670JV
UT WOS:000283418500001
PM 20300478
OA Green Submitted, gold, Green Published
DA 2025-06-11
ER

PT J
AU Goodman, E
   McEwen, BS
   Huang, B
   Dolan, LM
   Adler, NE
AF Goodman, E
   McEwen, BS
   Huang, B
   Dolan, LM
   Adler, NE
TI Social inequalities in biomarkers of cardiovascular risk in adolescence
SO PSYCHOSOMATIC MEDICINE
LA English
DT Article
DE adolescence; socioeconomic status; disparities; insulin; allostatic load
ID SOCIOECONOMIC-STATUS; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   DIABETES-MELLITUS; CHILDREN; STRESS; OBESITY; HEALTH; HEART; CHILDHOOD
AB Objective: Cardiovascular disease, which begins early in life but often is not manifest until adulthood, is the nation's leading cause of mortality. Social inequalities in cardiovascular disease are pervasive, yet the process by which they accrue is poorly understood. The objective of this study was to explore the associations between socioeconomic status, a range of biomarkers reflective of cardiovascular risks, and a cumulative physiological risk score among adolescents. Methods: Non-Hispanic black and white high school students (N = 758) in a suburban Midwestern public school district had a physical examination to measure height, weight, and waist circumference and a fasting morning blood sample drawn to assess cortisol, insulin, glucose, glycosylated hemoglobin, fibrinogen, low-density lipoprotein (LDL) and high-density lipoprotein (HDL) cholesterol, and triglycerides. A cumulative risk score was created from these physiological measures and waist circumference. Information on parent education and household income was obtained from a parent in a separate survey. Generalized estimating equation models were used to assess the association of parent education to the risks and the cumulative risk score adjusting for age, gender, and race. Results: Lower parent education was associated with higher insulin, higher glucose, greater insulin resistance, higher LDL cholesterol, lower HDL cholesterol, higher waist circumference, and higher body mass index (p<.05 for all), but not cortisol, fibrinogen, glycosylated hemoglobin, or triglycerides in adjusted analyses. Cumulative risk scores ranged from 0 to 7 and were highly skewed; the median risk score was 1. A total of 7.4% had risk scores of 4 or more. Lower parent education was also associated with higher cumulative risk score (P<.001) and this association was maintained after adjustment for body mass index. Risk scores were highest, on average, among those with insulin levels greater than I standard deviation above the mean (mean risk score = 3.2, standard error = 0.18, median = 3). Conclusion: Lower parent education is associated with multiple metabolic risks and cumulative risk in adolescents, suggesting that there is a strong intergenerational transfer of education's influence on cardiovascular health. Our data imply that regulation of insulin may be a key factor underlying the influence of lower parent education on cardiovascular health early in the life course. Key words: adolescence, socioeconomic status, disparities, insulin, allostatic load.
C1 Brandeis Univ, Heller Sch Social Policy & Management, Waltham, MA 02453 USA.
   Rockefeller Univ, Harold & Margaret Milliken Hatch Lab Neuroendocri, New York, NY 10021 USA.
   Cincinnati Childrens Hosp, Ctr Med, Ctr Biostat & Epidemiol, Cincinnati, OH USA.
   Cincinnati Childrens Hosp, Ctr Med, Div Endocrinol, Cincinnati, OH USA.
   Univ Calif San Francisco, Sch Med, Dept Psychiat, San Francisco, CA 94143 USA.
C3 Brandeis University; Rockefeller University; Cincinnati Children's
   Hospital Medical Center; Cincinnati Children's Hospital Medical Center;
   University of California System; University of California San Francisco
RP Brandeis Univ, Heller Sch Social Policy & Management, MS 35,415 S St, Waltham, MA 02453 USA.
EM goodman@brandeis.edu
RI Huang, Bin/G-2468-2014; Adler, Nancy/ABR-3334-2022; McEwen,
   Bruce/Z-1630-2019
FU NCRR NIH HHS [M01 RR 08084] Funding Source: Medline; NICHD NIH HHS [R01
   HD041527, HD41527] Funding Source: Medline; NIDDK NIH HHS [DK59183]
   Funding Source: Medline
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PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0033-3174
EI 1534-7796
J9 PSYCHOSOM MED
JI Psychosom. Med.
PD JAN-FEB
PY 2005
VL 67
IS 1
BP 9
EP 15
DI 10.1097/01.psy.0000149254.36133.1a
PG 7
WC Psychiatry; Psychology; Psychology, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry; Psychology
GA 892TU
UT WOS:000226673700002
PM 15673618
DA 2025-06-11
ER

PT J
AU Khan, F
   Green, FC
   Forsyth, JS
   Greene, SA
   Morris, AD
   Belch, JJF
AF Khan, F
   Green, FC
   Forsyth, JS
   Greene, SA
   Morris, AD
   Belch, JJF
TI Impaired microvascular function in normal children: effects of adiposity
   and poor glucose handling
SO JOURNAL OF PHYSIOLOGY-LONDON
LA English
DT Article
ID SKIN BLOOD-FLOW; ENDOTHELIUM-DEPENDENT VASODILATION; CARDIOVASCULAR
   RISK; YOUNG ADULTHOOD; INSULIN-RESISTANCE; SODIUM-NITROPRUSSIDE;
   PHYSICAL-ACTIVITY; OXIDATIVE STRESS; SYNDROME-X; DYSFUNCTION
AB Clustering of cardiovascular risk factors is thought to occur early in life. The endothelium is an important regulator of microvascular function. We investigated the relationship between microvascular function and cardiovascular risk factors in 145 normal, healthy children aged 11-14 years. Skin microvascular responses, measured using laser Doppler imaging, to iontophoresis of acetylcholine (ACh) and sodium nitroprusside (SNP), were negatively correlated with percentage body fat (r = -0.20, P < 0.05 and r = -0. 18, P < 0.05, respectively). Subjects were stratified into quintiles based on 2-h, post-feeding glucose levels. Subjects in the upper glucose quintile (range 7.4-11.4 mmol l(-1)) showed significantly lower vasodilatation to both ACh (P < 0.005) and SNP (P < 0.02) than those in the lower quintile (range 3.9-4.9 mmol l(-1)). Waist-to-hip ratio and the fasting insulin resistance index were significantly greater in subjects in the upper quintile than those in the lower quintile (P < 0.001 and P < 0.05, respectively). Additionally, in subjects in the upper glucose quintile, fasting triglyceride correlated with fasting insulin (r = 0.59, P < 0.001) and with the fasting insulin resistance index (r = 0.49, P < 0.009), and plasma levels of cholesterol and 2-h glucose were also correlated (r = 0.40, P < 0.05). In a cross-section of normal children, microvascular function was negatively associated with adiposity. Additionally, in a subgroup of subjects, there was a clustering of high post-feeding glucose, impaired microvascular function, increased insulin resistance and higher central fat distribution. These findings suggest that risk factors for adult cardiovascular disease begin to cluster in normal children, which might have important consequences for development of atherosclerosis later in life.
C1 Univ Dundee, Ninewells Hosp & Med Sch, Vasc Dis Res Unit, Dept Med, Dundee DD1 9SY, Scotland.
   Univ Dundee, Ninewells Hosp & Med Sch, Tayside Inst Child Hlth, Dundee DD1 9SY, Scotland.
C3 University of Dundee; University of Dundee
RP Univ Dundee, Ninewells Hosp & Med Sch, Vasc Dis Res Unit, Dept Med, Dundee DD1 9SY, Scotland.
EM f.khan@durdee.ac.uk
RI Morris, Andrew/C-2837-2009; Belch, Jill JF/AAE-9189-2019
OI Khan, Faisel/0000-0002-9889-0229; Belch, Jill JF/0000-0001-8280-6689
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NR 40
TC 60
Z9 65
U1 0
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-3751
EI 1469-7793
J9 J PHYSIOL-LONDON
JI J. Physiol.-London
PD SEP 1
PY 2003
VL 551
IS 2
BP 705
EP 711
DI 10.1113/jphysiol.2003.045351
PG 7
WC Neurosciences; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Physiology
GA 727XK
UT WOS:000185686000030
PM 12824443
OA Green Published
DA 2025-06-11
ER

PT J
AU Ammann, P
   Marschall, S
   Kraus, M
   Schmid, L
   Angehrn, W
   Krapf, R
   Rickli, H
AF Ammann, P
   Marschall, S
   Kraus, M
   Schmid, L
   Angehrn, W
   Krapf, R
   Rickli, H
TI Characteristics and prognosis of myocardial infarction in patients with
   normal coronary arteries
SO CHEST
LA English
DT Article
DE angiography; coronary artery disease; myocardial infarction; syndrome X
ID NITRIC-OXIDE; HEART-DISEASE; THROMBOSIS; SPASM; PATHOGENESIS
AB Study objectives: Myocardial infarction with angiographically normal coronary arteries (MINC) is a life-threatening event with man open questions for physicians and patients, There are little data concerning the prognosis for patients with MINC,
   Design: Retrospective follow-up study,
   Setting: Tertiary referral center.
   Patients: Patients with MINC were investigated and compared to age- and sex-matched control subjects with myocardial infarction due to coronary artery disease (CAD). The patients were examined clinically using stress exercise and hyperventilation tests, Migraine and Raynaud's symptoms were determined by means of a standardized questionnaire. Serum lipoproteins; the seroprevalence of cytomegalovirus, Helicobacter pylori, and Chlamydia pneumoniae infections; and the most frequent causes of thrombophilia were assessed.
   Measurements and results: From > 4,300 angiographies that were pet-formed between 1989 and 1996, 21 patients with MINC were identified, The mean +/- SD patient age at the time of myocardial infarction was 42 +/- 7.5 years. When compared to control subjects (n 21), patients with MINC had fewer risk factors for CAD. In contrast, MINC patients had more frequent febrile reactions prior to myocardial infarction (six patients vs zero patients; p < 0.05), and the migraine score was significantly higher (7.1 +/- 6.3 vs 2.2 +/- 4.1; p < 0.01), The seroprevalence of antibodies against cytomegalovirus, C pneumoniae, and H pylori tended to be higher in patients with MINC and CAD as compared to matched healthy control subjects. Three patients with MINC cs none with CAD had coagulopathy, During follow-up (53 +/- 37 months), no major cardiac event occurred in the MINC group; no patients with MINC vs nine with CAD (p = 0.0001) underwent repeated angiography.
   Conclusion: High migraine score and prior febrile infection together with a lower cardiovascular risk profile are compatible with an inflammatory and a vasomotor component in the pathophysiology of the acute coronary event in MINC patients. The prognosis for these patients is excellent.
C1 Kantonsspital, Dept Cardiol, St Gallen, Switzerland.
   Kantonsspital, Inst Clin Hematol & Chem, St Gallen, Switzerland.
   Inst Microbiol & Immunol, St Gallen, Switzerland.
C3 Kantonsspital Aarau AG (KSA); Kantonsspital St. Gallen; Kantonsspital
   Aarau AG (KSA); Kantonsspital St. Gallen
RP Ammann, P (corresponding author), Triemli Hosp, Dept Cardiol, CH-8063 Zurich, Switzerland.
RI Ammann, Peter/IQW-5347-2023
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NR 27
TC 86
Z9 96
U1 0
U2 0
PU AMER COLL CHEST PHYSICIANS
PI NORTHBROOK
PA 3300 DUNDEE ROAD, NORTHBROOK, IL 60062-2348 USA
SN 0012-3692
J9 CHEST
JI Chest
PD FEB
PY 2000
VL 117
IS 2
BP 333
EP 338
DI 10.1378/chest.117.2.333
PG 6
WC Critical Care Medicine; Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Respiratory System
GA 286MH
UT WOS:000085449400010
PM 10669671
DA 2025-06-11
ER

PT J
AU Arrebola-Moreno, AL
   Arrebola, JP
   Moral-Ruiz, A
   Ramirez-Hernandez, JA
   Melgares-Moreno, R
   Kaski, JC
AF Luis Arrebola-Moreno, Antonio
   Pedro Arrebola, Juan
   Moral-Ruiz, Antonio
   Antonio Ramirez-Hernandez, Jose
   Melgares-Moreno, Rafael
   Carlos Kaski, Juan
TI Coronary microvascular spasm triggers transient ischemic left
   ventricular diastolic abnormalities in patients with chest pain and
   angiographically normal coronary arteries
SO ATHEROSCLEROSIS
LA English
DT Article
DE Stable angina; Unobstructed coronary arteries; Echocardiographic
   diastolic changes; Ultrasensitive cardiac troponins; Epicardial coronary
   artery spasm; Coronary microvascular spasm
ID CARDIAC SYNDROME-X; CARDIOVASCULAR MAGNETIC-RESONANCE;
   MYOCARDIAL-PERFUSION DEFECTS; ANGINA-PECTORIS; DYSFUNCTION;
   ACETYLCHOLINE; ECHOCARDIOGRAPHY; STRESS; POPULATION; ERGONOVINE
AB Aims: Impaired coronary microvascular dilatory function can lead to exercise induced myocardial ischemia and angina pectoris even in patients without significant (>50%) obstructive coronary atherosclerosis (APWOCA). Diffuse distal vessel epicardial spasm and microvascular spasm have been also proposed as a plausible explanation for angina at rest in these patients. However, objective systematic evidence for the latter i.e. echocardiographic wall motion abnormalities during angina, is lacking at present. Coronary epicardial and microvascular spasm can be triggered in susceptible patients by the administration of intracoronary acetylcholine (Ach). We sought to assess whether Ach induced diffuse distal epicardial coronary artery spasm (>= 75% diameter reduction) and coronary microvascular spasm can cause transient ischemic left ventricular dysfunction, as assessed by echocardiography.
   Methods: 50 patients (19 men aged 60.5 +/- 8.9 years) with stable APWOCA were assessed for coronary spasm and myocardial ischemia with intracoronary Ach infusion, 2D transthoracic echocardiography (before and during Ach testing), continuous 12-lead ECG monitoring, and ultrasensitive cardiac troponin (US-cTn) measurement before and within 4 h after Ach testing.
   Results: 14 patients (28%) had a "negative" Ach test, 14 (28%) developed coronary microvascular spasm and 17 (34%) had diffuse distal epicardial spasm. In 5 patients (10%) the test was inconclusive. Echocardiographic variables including deceleration time, EF slope and E/A, as well as ultrasensitive-cTn concentrations were abnormal during Ach induced ischemic ECG changes.
   Conclusions: We have, for the first time, demonstrated that Ach induced coronary microvascular spasm is associated with echocardiographic changes and ultrasensitive-cTn elevations, indicative of myocardial ischemia. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
C1 [Luis Arrebola-Moreno, Antonio; Antonio Ramirez-Hernandez, Jose; Melgares-Moreno, Rafael; Carlos Kaski, Juan] Hosp Univ Virgen Nieves, Serv Cardiol, Unidad Hemodinam, Granada, Spain.
   [Luis Arrebola-Moreno, Antonio] St Georges Univ London, Cardiovasc & Cell Sci Res Inst, London SW17 0RE, England.
   [Pedro Arrebola, Juan] Univ Granada, Hosp Univ San Cecilio, Lab Invest Med, Granada, Spain.
   [Moral-Ruiz, Antonio] Hosp Univ Virgen Nieves, Nucl Med Serv, Granada, Spain.
C3 Hospital Universitario Virgen de las Nieves; City St Georges, University
   of London; St Georges University London; University of Granada; Hospital
   Universitario San Cecilio; Hospital Universitario Virgen de las Nieves
RP Kaski, JC (corresponding author), St Georges Univ London, Cardiovasc & Cell Sci Res Inst, Cranmer Terrace, London SW17 0RE, England.
EM jkaski@sgul.ac.uk
RI Kaski, Juan Carlos/LKM-8031-2024; Arrebola, Juan/A-5205-2017
OI Arrebola, Juan P./0000-0002-8643-2423
FU Nieves M Coronado-Alvarez from H. U San Cecilio, Granada, Spain;
   Norberto Herrera-Gomez; Joaquin Sanchez-Gila; Jose A Romero-Hinojosa;
   Eduardo Molina-Navarro from H.U. Virgen de las Nieves, Granada, Spain;
   Amelia Carro-Hevia from H.U. Vall d'Hebron. Barcelona, Spain
FX The authors greatly appreciate the support of Nieves M Coronado-Alvarez
   from H. U San Cecilio, Granada, Spain; Norberto Herrera-Gomez, Joaquin
   Sanchez-Gila, Jose A Romero-Hinojosa and Eduardo Molina-Navarro from
   H.U. Virgen de las Nieves, Granada, Spain; Amelia Carro-Hevia from H.U.
   Vall d'Hebron. Barcelona, Spain; the nurses, technicians, auxiliary and
   ward staff in the catheterization laboratories of H.U. Virgen de las
   Nieves and St George's Hospital, and all members of staff.
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NR 30
TC 34
Z9 37
U1 0
U2 6
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0021-9150
EI 1879-1484
J9 ATHEROSCLEROSIS
JI Atherosclerosis
PD SEP
PY 2014
VL 236
IS 1
BP 207
EP 214
DI 10.1016/j.atherosclerosis.2014.07.009
PG 8
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA AP9PP
UT WOS:000342412000030
PM 25075937
OA Bronze
DA 2025-06-11
ER

PT J
AU Merz, CNB
   Olson, MB
   McClure, C
   Yang, YC
   Symons, J
   Sopko, G
   Kelsey, SF
   Handberg, E
   Johnson, BD
   Cooper-DeHoff, RM
   Sharaf, B
   Rogers, WJ
   Pepine, CJ
AF Merz, C. Noel Bairey
   Olson, Marian B.
   McClure, Candace
   Yang, Yu-Ching
   Symons, James
   Sopko, George
   Kelsey, Sheryl F.
   Handberg, Eileen
   Johnson, B. Delia
   Cooper-DeHoff, Rhonda M.
   Sharaf, Barry
   Rogers, William J.
   Pepine, Carl J.
TI A randomized controlled trial of low-dose hormone therapy on myocardial
   ischemia in postmenopausal women with no obstructive coronary artery
   disease: Results from the National Institutes of Health/National Heart,
   Lung, and Blood Institute-sponsored Women's Ischemia Syndrome Evaluation
   (WISE)
SO AMERICAN HEART JOURNAL
LA English
DT Article
ID ESTROGEN PLUS PROGESTIN; QUALITY-OF-LIFE; CHEST-PAIN; SYNDROME-X;
   ENDOTHELIAL DYSFUNCTION; CARDIOVASCULAR-DISEASE; TERM; ATHEROSCLEROSIS;
   ANGIOGRAMS; ANGINA
AB Background Compared with men, women have more evidence of myocardial ischemia with no obstructive coronary artery disease. Although low endogenous estrogen levels are associated with endothelial dysfunction, the role of low-dose hormone therapy has not been fully evaluated. We postulate that a 12-week duration of low-dose hormone replacement therapy is associated with myocardial ischemia and endothelial dysfunction.
   Methods and Results Using a multicenter, randomized, placebo-controlled design, subjects were randomized to receive either 1 mg norethindrone/10 mu g ethinyl estradiol or placebo for 12 weeks. Chest pain and menopausal symptoms, cardiac magnetic resonance spectroscopy, brachial artery reactivity, exercise stress testing, and psychosocial questionnaires were evaluated at baseline and exit. Recruitment was closed prematurely because of failure to recruit after publication of the Women's Health Initiative hormone trial. Of the 35 women who completed the study, there was less frequent chest pain in the treatment group compared with the placebo group (P=.02) at exit. Women taking 1 mg norethindrone/10 mu g ethinyl estradiol also had significantly fewer hot flashes/night sweats (P=.003), less avoidance of intimacy (P=.05), and borderline differences in sexual desire and vaginal dryness (P=.06). There were no differences in magnetic resonance spectroscopy, brachial artery reactivity, compliance, or reported adverse events between the groups.
   Conclusions These data suggest that low-dose hormone therapy improved chest pain symptoms, menopausal symptoms, and quality of life, but did not improve ischemia or endothelial dysfunction. Given that it was not possible to enroll the prespecified sample size, these results should not be considered definitive. (Am Heart J 2010; 159: 987.e1-987.e7.)
C1 [Merz, C. Noel Bairey; Yang, Yu-Ching] Cedars Sinai Med Ctr, Cedars Sinai Res Inst, Dept Med, Div Cardiol, Los Angeles, CA 90048 USA.
   [Olson, Marian B.; McClure, Candace; Kelsey, Sheryl F.; Johnson, B. Delia] Univ Pittsburgh, Dept Epidemiol, Grad Sch Publ Hlth, Pittsburgh, PA 15261 USA.
   [Sopko, George] NHLBI, NIH, Bethesda, MD 20892 USA.
   [Handberg, Eileen; Cooper-DeHoff, Rhonda M.; Pepine, Carl J.] Univ Florida, Dept Med, Div Cardiol, Gainesville, FL USA.
   [Sharaf, Barry] Rhode Isl Hosp, Div Cardiol, Providence, RI USA.
   [Rogers, William J.] Univ Alabama, Dept Med, Div Cardiovasc Dis, Birmingham, AL 35294 USA.
C3 Cedars Sinai Medical Center; Pennsylvania Commonwealth System of Higher
   Education (PCSHE); University of Pittsburgh; National Institutes of
   Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI);
   State University System of Florida; University of Florida; Lifespan
   Health Rhode Island; Rhode Island Hospital; University of Alabama
   System; University of Alabama Birmingham
RP Merz, CNB (corresponding author), Univ Pittsburgh, WISE Coordinating Ctr, Grad Sch Publ Hlth, 127 Parran Hall,130 DeSoto St, Pittsburgh, PA 15261 USA.
EM merz@cshs.org
RI Wang, Yuhui/JTT-7711-2023
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NR 44
TC 31
Z9 33
U1 0
U2 5
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0002-8703
J9 AM HEART J
JI Am. Heart J.
PD JUN
PY 2010
VL 159
IS 6
BP 987
EP U9
AR 987.e1
DI 10.1016/j.ahj.2010.03.024
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 607UU
UT WOS:000278533200009
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Hillier, E
   Elharram, M
   White, JA
   Anderson, T
   Luu, J
   Labib, D
   Alhussein, M
   Friedrich, MG
   Pilote, L
AF Hillier, Elizabeth
   Elharram, Malik
   White, James A.
   Anderson, Todd
   Luu, Judy
   Labib, Dina
   Alhussein, Muhammad
   Friedrich, Matthias G.
   Pilote, Louise
TI Heterogeneity of coronary vascular function and myocardial oxygenation
   in women with angina and non-obstructive coronary artery disease
SO EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
LA English
DT Article
DE ANOCA; OS-CMR; B-MORE; angina with no obstructive coronary artery
   disease; oxygenation sensitive; myocardial oxygenation; vasoactive
   breathing manoeuvres; cardiac MRI; CMR
ID RISK-FACTORS; SYNDROME-X; ISCHEMIA; HEART; WISE; PATHOPHYSIOLOGY;
   DYSFUNCTION; CARDIOLOGY; INSIGHTS; STRESS
AB Aims Women with angina and non-obstructive coronary artery disease (ANOCA) have a heightened risk for cardiovascular events, and the pathophysiology for ischaemic symptoms may be related to alterations in microvascular structure and function. We examined the use of breathing-enhanced oxygenation-sensitive cardiac magnetic resonance imaging (OS-CMR) using vasoactive breathing manoeuvres to assess myocardial oxygenation in women with ANOCA.Methods and results We recruited women (aged 40-65 years) from two sites in Canada who presented to healthcare with persistent retrosternal chest pain and found to have ANOCA, or without a history of cardiovascular disease. All participants were scanned using a clinical 3T MRI scanner, and OS-CMR images were acquired over a breath hold following paced hyperventilation to measure global and regional measurements of heterogeneity. Fifty-four women with ANOCA (age: 55 +/- 6.2 years) and 48 healthy controls (age: 51.2 +/- 4.8 years) were recruited. There was no significant difference in volume, function, mass, or global myocardial oxygenation between the two groups [mean %Delta in signal intensity (SI): 4.9 (+/- 7.3) vs. 4.5 (+/- 10.1), P = 0.82]. Women with ANOCA had higher regional variations in myocardial oxygenation in circumferential [median %Delta in SI: 5.1 (2.0-7.6) vs. 2.2 (1.4-3.5), P = 0.0004] and longitudinal directions [median %Delta in SI: 11.4 (5.4-16.7) vs. 6.0 (3.0-7.0), P = 0.001], which remained present in a multivariate model.Conclusion Heterogeneous myocardial oxygenation may explain ischaemic symptoms without any associated epicardial obstructive coronary artery disease. Regional variations in myocardial oxygenation on OS-CMR could serve as an important diagnostic marker for microvascular dysfunction in women with ANOCA.
   Graphical Abstract
C1 [Hillier, Elizabeth; Luu, Judy; Friedrich, Matthias G.; Pilote, Louise] McGill Univ, Fac Med & Hlth Sci, 3605 Montagne, Montreal, PQ H3G 2M1, Canada.
   [Hillier, Elizabeth; Elharram, Malik] Univ Alberta, Fac Med & Dent, 2J2 00 Walter C MacKenzie Hlth Sci Ctr, Edmonton, AB T6G 2R7, Canada.
   [White, James A.; Anderson, Todd; Labib, Dina; Alhussein, Muhammad] Univ Calgary, Fac Med, 2500 Univ Dr NW, Calgary, AB T2N 1N4, Canada.
   [Pilote, Louise] McGill Univ, Hlth Ctr, Ctr Outcomes Res & Evaluat, 5252 Blvd Maisonneuve West, Montreal, PQ H3A 1A1, Canada.
C3 McGill University; University of Alberta; University of Calgary; McGill
   University
RP Pilote, L (corresponding author), McGill Univ, Fac Med & Hlth Sci, 3605 Montagne, Montreal, PQ H3G 2M1, Canada.; Pilote, L (corresponding author), McGill Univ, Hlth Ctr, Ctr Outcomes Res & Evaluat, 5252 Blvd Maisonneuve West, Montreal, PQ H3A 1A1, Canada.
EM louise.pilote@mcgill.ca
RI Labib, Dina/GMX-0374-2022
OI Labib, Dina/0000-0001-7108-8554; Pilote, Louise/0000-0002-6159-0628
FU Canadian Institutes of Health Research award
   [201709PJT-389497-CID-CFAC-40513]
FX Canadian Institutes of Health Research award
   #201709PJT-389497-CID-CFAC-40513.
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NR 32
TC 3
Z9 3
U1 0
U2 0
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 2047-2404
EI 2047-2412
J9 EUR HEART J-CARD IMG
JI Eur. Heart J.-Cardiovasc. Imaging
PD APR 9
PY 2024
VL 25
IS 8
BP 1136
EP 1143
DI 10.1093/ehjci/jeae076
EA APR 2024
PG 8
WC Cardiac & Cardiovascular Systems; Radiology, Nuclear Medicine & Medical
   Imaging
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Radiology, Nuclear Medicine &
   Medical Imaging
GA A2V5G
UT WOS:001198747200001
PM 38546135
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Liga, R
   Rovai, D
   Sampietro, T
   Vecoli, C
   Todiere, G
   Caselli, C
   Rossi, G
   L'Abbate, A
   Neglia, D
AF Liga, Riccardo
   Rovai, Daniele
   Sampietro, Tiziana
   Vecoli, Cecilia
   Todiere, Giancarlo
   Caselli, Chiara
   Rossi, Giuseppe
   L'Abbate, Antonio
   Neglia, Danilo
TI Insulin resistance is a major determinant of myocardial blood flow
   impairment in anginal patients
SO EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
LA English
DT Article
DE Insulin resistance; Endothelial/microvascular dysfunction; PET; MBF
ID CORONARY MICROVASCULAR DYSFUNCTION; POSITRON-EMISSION-TOMOGRAPHY;
   DILATED CARDIOMYOPATHY; GLUCOSE-TOLERANCE; PERFUSION RESERVE; STABLE
   ANGINA; HEART-DISEASE; SYNDROME-X; GUIDELINES
AB Purpose In patients with chest pain, stress-induced myocardial perfusion abnormalities are often the result of depressed myocardial blood flow (MBF) reserve. We investigated the relative contribution of cardiovascular risk factors and coronary atherosclerosis to MBF abnormalities in anginal patients.
   Methods We studied 167 patients with typical (n = 100) or atypical (n = 67) chest pain who underwent quantitative evaluation of MBF by PET at rest and after dipyridamole infusion, and quantitative coronary angiography (invasive or by 64-slice CT). Patients with left ventricular (LV) dysfunction (ejection fraction < 45 %) were excluded. Coronary athero-sclerosis of >= 50 % was defined as obstructive.
   Results At rest median MBF was 0.60 ml min(-1) g(-1), and after dipyridamole infusion median MBF was 1.22 ml min(-1) g(-1). MBF reserve was < 2 in 77 of 167 patients (46 %). Coronary atherosclerosis was present in 67 patients (40 %), 26 with obstructive disease. In a univariate analysis several variables were associated with reduced MBF at rest, including male gender, coronary atherosclerosis and elevated LV end-diastolic diameter, and during hyperaemia, including male gender, insulin resistance (IR), smoking habit, LV ejection fraction and end-diastolic diameter. In a multivariate analysis, after adjustment for LV function and for pharmacological treatments, male gender was the only independent predictor of reduced MBF at rest (P < 0.001), while male gender (P=0.003), IR (P=0.033) and coronary atherosclerosis (P < 0.001) remained the only independent predictors of reduced hyperaemic MBF. IR (P=0.043) and coronary atherosclerosis (P=0.005) were the only predictors of depressed MBF reserve. Coronary atherosclerosis, male gender and IR showed additive effects on hyperaemic MBF.
   Conclusion In patients with chest pain and normal LV systolic function, IR, male gender and coronary atherosclerosis are independent and additive determinants of impaired hyperaemic MBF.
C1 [Liga, Riccardo; Vecoli, Cecilia; L'Abbate, Antonio] Scuola Super Sant Anna, Pisa, Italy.
   [Rovai, Daniele; Sampietro, Tiziana; Caselli, Chiara; Rossi, Giuseppe; Neglia, Danilo] CNR, Inst Clin Physiol, I-56124 Pisa, Italy.
   [Todiere, Giancarlo; Neglia, Danilo] Fdn Toscana G Monasterio, Pisa, Italy.
C3 Scuola Superiore Sant'Anna; Consiglio Nazionale delle Ricerche (CNR);
   Istituto di Fisiologia Clinica (IFC-CNR)
RP Neglia, D (corresponding author), CNR, Inst Clin Physiol, Via G Moruzzi 1, I-56124 Pisa, Italy.
EM dneglia@ifc.cnr.it
RI Neglia, Danilo/AAR-6384-2020; Rossi, Giuseppe/G-7838-2012; Liga,
   Riccardo/AAC-1691-2019; Caselli, Chiara/I-7922-2014; Vecoli,
   Cecilia/K-8613-2016
OI Liga, Riccardo/0000-0002-9964-5604; Caselli, Chiara/0000-0001-6705-2460;
   Vecoli, Cecilia/0000-0002-5921-3604; Neglia, Danilo/0000-0003-0016-9538
FU European Union [222915]
FX We thank Piero Salvadori, Luca Menichetti and Silvia Pardini for their
   participation to the cardiac PET studies. This study was partially
   supported by a grant from the European Union FP7-CP-FP 2007 project
   (grant agreement no. 222915, EVINCI).
CR Bonora E, 2000, DIABETES CARE, V23, P57, DOI 10.2337/diacare.23.1.57
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NR 27
TC 8
Z9 8
U1 0
U2 6
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1619-7070
EI 1619-7089
J9 EUR J NUCL MED MOL I
JI Eur. J. Nucl. Med. Mol. Imaging
PD DEC
PY 2013
VL 40
IS 12
BP 1905
EP 1913
DI 10.1007/s00259-013-2523-7
PG 9
WC Radiology, Nuclear Medicine & Medical Imaging
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Radiology, Nuclear Medicine & Medical Imaging
GA 248HZ
UT WOS:000326690600015
DA 2025-06-11
ER

PT J
AU Durakoglugil, ME
   Kocaman, SA
   Çetin, M
   Kirbas, A
   Çanga, A
   Erdogan, T
   Çiçek, Y
AF Durakoglugil, Murtaza Emre
   Kocaman, Sinan Altan
   Cetin, Mustafa
   Kirbas, Aynur
   Canga, Aytun
   Erdogan, Turan
   Cicek, Yuksel
TI Increased circulating soluble CD40 levels in patients with slow coronary
   flow phenomenon: an observational study
SO ANADOLU KARDIYOLOJI DERGISI-THE ANATOLIAN JOURNAL OF CARDIOLOGY
LA English
DT Article
DE Slow coronary flow; soluble CD40; C-reactive protein; coronary
   angiography; regression analysis
ID HUMAN VASCULAR CELLS; ENDOTHELIAL FUNCTION; OXIDATIVE STRESS;
   ANGINA-PECTORIS; HUMAN MONOCYTES; ARTERY FLOW; SYNDROME-X; EXPRESSION;
   LIGAND; ATHEROSCLEROSIS
AB Objective: Slow coronary flow (SCF) is an angiographic finding characterized with delayed opacification of epicardial coronary arteries without obstructive coronary disease. CD40/CD40 ligand (CD40L) signaling seems closely related to atherosclerosis due to increased inflammation and prothrombotic state. We investigated whether soluble CD40 (sCD40), an indirect marker of CD40/CD40L dyad, is related to SCF.
   Methods: The present study was cross-sectional and observational, consisting of seventy individuals who underwent coronary angiography with suspicion of CAD and had angiographically normal coronary arteries of varying coronary flow rates. The relationship between sCD40, C-reactive protein (CRP) and SCF phenomenon was investigated. Fifty patients with isolated SCF (mean age: 56 +/- 10 years) and 20 age- and gender-matched control participants with normal coronary flow (NCF) and normal coronary arteries (NCA), (mean age: 55 +/- 10 years) were included in the study. We used logistic regression analysis to determine the predictors of SCF.
   Results: The clinical characteristics were not statistically significant different between SCF and NCA group. Serum CRP levels were also similar between two groups. Serum sCD40 level was significantly higher in the SCF group compared to control group (74 +/- 31 vs. 59 +/- 16 pg/mL, p=0.014). In multiple regression analyses, mean coronary diameter strongly (OR: 7.358, 95% CI: 1.990-27.20, p=0.003) and sCD40 (OR: 1.044, 95% CI: 1.006-1.084, p=0.023) weakly predicted SCF.
   Conclusion: This study revealed, significantly increased serum sCD40 levels in patients with SCF. Although we cannot conclude the underlying pathological process of SCF, we believe that these findings may be pivotal for further studies searching the specific roles of CD40/CD40L signaling on SCF phenomenon in coronary vasculature. (Anadolu Kardiyol Derg 2013; 13: 39-44)
C1 [Durakoglugil, Murtaza Emre; Erdogan, Turan; Cicek, Yuksel] Recep Tayyip Erdogan Univ, Fac Med, Dept Cardiol, TR-53100 Rize, Turkey.
   [Kirbas, Aynur] Recep Tayyip Erdogan Univ, Fac Med, Dept Biochem, TR-53100 Rize, Turkey.
   [Kocaman, Sinan Altan; Cetin, Mustafa; Canga, Aytun] Rize Educ & Res Hosp, Clin Cardiol, Rize, Turkey.
C3 Recep Tayyip Erdogan University; Recep Tayyip Erdogan University; Rize
   Training & Research Hospital
RP Durakoglugil, ME (corresponding author), Recep Tayyip Erdogan Univ, Fac Med, Dept Cardiol, Islampasa Mah, TR-53100 Rize, Turkey.
EM emredur@hotmail.com
RI KIRBAS, Aynur/JSK-8787-2023; Durakoglugil, Emre/Q-3547-2019; Cetin,
   Mustafa/A-2919-2016
OI Cetin, Mustafa/0000-0001-6342-436X
CR Ari H, 2010, TURK KARDIYOL DERN A, V38, P327
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NR 38
TC 13
Z9 14
U1 0
U2 4
PU AVES YAYINCILIK
PI FINDIKZADE
PA IBRAHIM KARA, KIZILELMA CAD 5-3, FINDIKZADE, ISTANBUL 34096, TURKEY
SN 1302-8723
J9 ANADOLU KARDIYOL DER
JI Anadolu Kardiyol. Derg.
PD FEB
PY 2013
VL 13
IS 1
BP 39
EP 44
DI 10.5152/akd.2013.005
PG 6
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 123BB
UT WOS:000317361900006
PM 23070634
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Moteshafi, H
   Zhornitsky, S
   Brunelle, S
   Stip, E
AF Moteshafi, Hoda
   Zhornitsky, Simon
   Brunelle, Sarah
   Stip, Emmanuel
TI Comparing Tolerability of Olanzapine in Schizophrenia and Affective
   Disorders A Meta-Analysis
SO DRUG SAFETY
LA English
DT Review
ID PLACEBO-CONTROLLED TRIAL; BIPOLAR-I DISORDER; DRUG-NAIVE PATIENTS;
   INDUCED WEIGHT-GAIN; DOUBLE-BLIND; ATYPICAL ANTIPSYCHOTICS; ACUTE MANIA;
   1ST-EPISODE SCHIZOPHRENIA; TARDIVE-DYSKINESIA; GLUCOSE-TOLERANCE
AB Background: Olanzapine is prescribed for a number of psychiatric disorders, including schizophrenia, bipolar mania, and unipolar and bipolar depression. Olanzapine treatment is associated with tolerability issues such as metabolic adverse effects (e.g. weight gain, increase in blood glucose, triglycerides and total cholesterol levels), extrapyramidal symptoms [EPS] (e.g. parkinsonism, akathisia, tardive dyskinesia) and sedative adverse effects. Metabolic issues lead to some long-term consequences, which include cardiovascular diseases (CVD) and type 2 diabetes mellitus, and these complications cause high rates of mortality and morbidity among patients with severe mental illnesses. The expanded indications of olanzapine in psychiatry suggest a need to investigate whether there is a difference in the incidence and severity of adverse effects related to category diagnosis. Are the adverse effects expressed differently according to phenotype? Unfortunately, there are no reported studies that investigated these differences in adverse effects associated with olanzapine treatment in psychiatric patients with different phenotypes.
   Objective: The aim of the present meta-analysis is to separately examine olanzapine-induced cardiometabolic adverse effects and EPS in patients with schizophrenia and affective disorders.
   Data Sources: A search of computerized literature databases PsycINFO (1967-2010), PubMed (MEDLINE), EMBASE (1980-2010) and the clinicaltrials.gov website for randomized clinical trials was conducted. A manual search of reference lists of published review articles was carried out to gather further data.
   Study Selection: Randomized controlled trials were included in our study if (i) they assessed olanzapine adverse effects (metabolic or extrapyramidal) in adult patients with schizophrenia or affective disorders; and (ii) they administered oral olanzapine as monotherapy during study.
   Data Extraction: Two reviewers independently screened abstracts for choosing articles and one reviewer extracted relevant data on the basis of predetermined exclusion and inclusion criteria. It should be mentioned that for the affective disorders group we could only find articles related to bipolar disorder.
   Data Synthesis: Thirty-three studies (4831 patients) that address olanzapine monotherapy treatment of adults with schizophrenia or bipolar disorder were included in the analysis. The primary outcomes were metabolic adverse effects (changes in weight, blood glucose, low-density lipoprotein, total cholesterol and triglyceride levels). The secondary outcomes of our study were assessing the incidence of some EPS (parkinsonism, akathisia and use of antiparkinson medication). The tolerability outcomes were calculated separately for the schizophrenia and bipolar disorder groups and were combined in a meta-analysis. Tolerability outcomes show that olanzapine contributes to weight gain and elevates blood triglycerides, glucose and total cholesterol levels in both schizophrenia and bipolar disorder patients. However, olanzapine treatment produced significantly more weight gain in schizophrenia patients than in bipolar disorder patients. In addition, increases in blood glucose, total cholesterol and triglyceride levels were higher in the schizophrenia group compared with the bipolar disorder group, even though these differences were not statistically significant. Based on our results, the incidence of parkinsonism was significantly higher in the schizophrenia group than in the bipolar disorder group. Subgroup analysis and logistic regression were used to assess the influence of treatment duration, dose, industry sponsorship, age and sex ratio on tolerability outcome.
   Conclusions: Our results suggest that schizophrenia patients may be more vulnerable to olanzapine-induced weight gain. The findings may be explained by considering the fact that in addition to genetic disposition for metabolic syndrome in schizophrenia patients, they have an especially high incidence of lifestyle risk factors for CVD, such as poor diet, lack of exercise, stress and smoking. It might be that an antipsychotic induces severity of adverse effect according to the phenotype.
C1 [Moteshafi, Hoda; Zhornitsky, Simon; Stip, Emmanuel] Hop Louis H Lafontaine, Ctr Rech Fernand Seguin, Montreal, PQ H1N 3V2, Canada.
   [Moteshafi, Hoda; Stip, Emmanuel] Univ Montreal, Dept Pharmacol, Montreal, PQ H3C 3J7, Canada.
   [Zhornitsky, Simon; Brunelle, Sarah; Stip, Emmanuel] Univ Montreal, Dept Psychiat, Montreal, PQ H3C 3J7, Canada.
C3 Universite de Montreal; Universite de Montreal; Universite de Montreal
RP Stip, E (corresponding author), Hop Louis H Lafontaine, Ctr Rech Fernand Seguin, 7331 Hochelaga, Montreal, PQ H1N 3V2, Canada.
EM emmanuel.stip@umontreal.ca
OI Zhornitsky, Simon/0000-0003-2024-7062
FU Pfizer; AstraZeneca; Eli Lilly Canada
FX Emmanuel Stip is holder of the Eli Lilly Chair on Schizophrenia from the
   University of Montreal. This study was supported in part by an operating
   grant, IIT (Investigator-Initiated Trial), from Pfizer, AstraZeneca, and
   Eli Lilly Canada; however, no funding was received for this specific
   meta-analysis. All other authors have no conflicts of interest to
   declare that are directly relevant to the content of this review.
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NR 90
TC 22
Z9 23
U1 0
U2 20
PU ADIS INT LTD
PI NORTHCOTE
PA 5 THE WAREHOUSE WAY, NORTHCOTE 0627, AUCKLAND, NEW ZEALAND
SN 0114-5916
EI 1179-1942
J9 DRUG SAFETY
JI Drug Saf.
PY 2012
VL 35
IS 10
BP 819
EP 836
DI 10.1007/BF03261978
PG 18
WC Public, Environmental & Occupational Health; Pharmacology & Pharmacy;
   Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health; Pharmacology & Pharmacy;
   Toxicology
GA 010GT
UT WOS:000309083600005
PM 22967188
DA 2025-06-11
ER

PT J
AU Hagemann, CE
   Hoffmann, S
   Olsen, FJ
   Jorgensen, PG
   Fritz-Hansen, T
   Jensen, JS
   Biering-Sorensen, T
AF Hagemann, Christoffer E.
   Hoffmann, Soren
   Olsen, Flemming J.
   Jorgensen, Peter G.
   Fritz-Hansen, Thomas
   Jensen, Jan S.
   Biering-Sorensen, Tor
TI Layer-specific global longitudinal strain reveals impaired cardiac
   function in patients with reversible ischemia
SO ECHOCARDIOGRAPHY-A JOURNAL OF CARDIOVASCULAR ULTRASOUND AND ALLIED
   TECHNIQUES
LA English
DT Article
DE coronary artery disease; echocardiography; myocardial strain
ID CORONARY-ARTERY-DISEASE; 2-DIMENSIONAL SPECKLE-TRACKING; DOBUTAMINE
   STRESS ECHOCARDIOGRAPHY; STABLE ANGINA-PECTORIS;
   DOPPLER-ECHOCARDIOGRAPHY; MYOCARDIAL-INFARCTION; SYNDROME-X; STENOSIS;
   QUANTIFICATION; DYSFUNCTION
AB AimsTwo-dimensional speckle tracking echocardiography (2DSTE) detects early signs of left ventricular dysfunction; however, it is unknown whether layer-specific global longitudinal strain (GLS) has incremental value in diagnosis of patients with reversible ischemia assessed by single photon emission computed tomography (SPECT).
   Methods and ResultsEighty patients with stable angina pectoris (SAP), normal left ventricular ejection fraction (LVEF), and no history of ischemic heart disease were retrospectively identified to have been examined by 2DSTE, SPECT, and coronary angiography (CAG). Patients with a normal SPECT constituted the control group, and patients with a positive SPECT were divided into patients with or without (true- or false- positive SPECT) significant stenosis assessed by CAG. GLS was measured for two myocardial layers (endocardial and epicardial) and as well as mid-myocardial GLS. Patients with reversible ischemia had significantly lower GLS compared to the control group (GLS(Endocardial): -19.04.4% vs -21.4 +/- 3.7%, P=.011; GLS(Epicardial): -14.3 +/- 2.9% vs -16.3 +/- 2.9%, P=.004); GLS(Mid-myocardial): -16.5 +/- 3.6% vs -18.6 +/- 3.2%, P=.006. This difference was even more evident in patients with a true-positive SPECT (GLS(Endocardial): -18.0 +/- 4.4% vs -21.4 +/- 3.7%, P<.001; GLS(Epicardial): -13.6 +/- 3.0% vs -16.3 +/- 2.9%, P<.001); GLS(Mid-myocardial): -15.6 +/- 3.6% vs -18.6 +/- 3.2%, P<.001. Notably, no significant differences existed in patients with a false-positive SPECT. GLS(Epicardial) was the only independent predictor of coronary artery disease.
   In conclusionIn patients with SAP and preserved LVEF, layer-specific GLS at rest identifies patients with reversible ischemia. This seems to be evident only in patients with a true-positive SPECT, thus, 2DSTE at rest might improve the diagnostic accuracy of a positive SPECT.
C1 [Hagemann, Christoffer E.; Hoffmann, Soren; Olsen, Flemming J.; Jorgensen, Peter G.; Fritz-Hansen, Thomas; Jensen, Jan S.; Biering-Sorensen, Tor] Univ Copenhagen, Herlev & Gentofte Hosp, Dept Cardiol, Fac Hlth Sci, Copenhagen, Denmark.
C3 University of Copenhagen
RP Hagemann, CE (corresponding author), Univ Copenhagen, Herlev & Gentofte Hosp, Dept Cardiol, Copenhagen, Denmark.
EM christofferhag@hotmail.com
RI Biering-Sørensen, Tor/G-9465-2013; Olsen, Flemming/AAS-8127-2021
OI Olsen, Flemming Javier/0000-0001-9511-8375; Biering-Sorensen,
   Tor/0000-0003-4209-2778
FU Family Hede Nielsens Foundation; Aase and Ejnar Danielsens Foundation;
   Augustinus Foundation
FX The study was supported by grants from the Family Hede Nielsens
   Foundation, Aase and Ejnar Danielsens Foundation, and the Augustinus
   Foundation. The sponsors had no role in the study design, data
   collection, data analysis, or writing of the manuscript.
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NR 40
TC 19
Z9 21
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0742-2822
EI 1540-8175
J9 ECHOCARDIOGR-J CARD
JI Echocardiography-J. Cardiovasc. Ultrasound Allied Tech.
PD MAY
PY 2018
VL 35
IS 5
BP 632
EP 642
DI 10.1111/echo.13830
PG 11
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA GG6RQ
UT WOS:000432826700006
PM 29446126
DA 2025-06-11
ER

PT J
AU Madaric, J
   Bartunek, J
   Verhamme, K
   Penicka, M
   Van Schuerbeeck, E
   Nellens, P
   Heyndrickx, GR
   Wijns, W
   Vanderheyden, M
   De Bruyne, B
AF Madaric, J
   Bartunek, J
   Verhamme, K
   Penicka, M
   Van Schuerbeeck, E
   Nellens, P
   Heyndrickx, GR
   Wijns, W
   Vanderheyden, M
   De Bruyne, B
TI Hyperdynamic myocardial response to beta-adrenergic stimulation in
   patients with chest pain and normal coronary arteries
SO JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
LA English
DT Article
ID DOBUTAMINE STRESS ECHOCARDIOGRAPHY; CARDIAC SYNDROME-X; ANGINA-PECTORIS;
   PERCEPTION; RESERVE; ARTERIOGRAMS; OBSTRUCTION; ENDOTHELIN
AB Objectives: The goal of this study was to test the hypothesis that an abnormal response to beta-adrenergic stimulation may play a role in the pathophysiology of chest pain in patients with normal coronary arteries.
   Background: The mechanism of angina-like (AL) chest pain in patients with angiographically normal coronary arteries remains controversial.
   Methods: Fifty-eight patients with AL pain and a normal coronary angiogram underwent dobutamine echocardiography (DE) to evaluate regional wall motion and intraventricular flow velocities (IFV). Control patients consisted of 22 matched patients free of angina and coronary artery disease. Abnormal IFV were defined as dagger-shaped Doppler spectrum >= 3 m/s.
   Results: Dobutamine-induced regional wall motion abnormalities did not develop in any of the patients. An IFV >= 3 m/s was found in 28 patients (48%) with AL pain but in only 4 (18%) control patients (p < 0.05). In the subgroup of patients with AL pain and IFV >= 3 m/s, plasma renin concentration (PRC) was higher as compared with those with IFV < 3 m/s (18 +/- 17 pg/ml vs. 9 +/- 6 pg/ml, p < 0.05). There were no differences in plasma ADR, NADR, or angiotensin-converting enzyme levels. Fourteen patients with angina and IFV >= 3 underwent control DE and blood sampling after 6 weeks treatment with 10 mg of bisoprolol. In these patients, a decrease in IFV (from 3.4 +/- 0.35 m/s to 2.46 +/- 0.64 m/s, p < 0.001) and a decrease in angina score (from 5.4 +/- 1.5 to 0.6 +/- 1.4, p < 0.001) were observed at follow-up.
   Conclusion: The present data suggest that an exaggerated myocardial response to beta-adrenergic stimulation plays a role in the mechanisms of chest pain in some patients with normal coronary arteries.
C1 Ctr Cardiovasc, Aalst, Belgium.
   OLV Clin, Dept Epidemiol, Aalst, Belgium.
RP Ctr Cardiovasc, Aalst, Belgium.
EM jozef.bartunek@olvz-aalst.be; bernard.de.bruyne@olvz-aalst.be
RI Wijns, William/ACQ-0269-2022; De Bruyne, Bernard/ACL-1718-2022;
   verhamme, katia/N-2782-2015
OI Madaric, Juraj/0000-0003-1326-2336; Wijns, William/0000-0002-7267-4376
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NR 30
TC 16
Z9 17
U1 0
U2 4
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0735-1097
EI 1558-3597
J9 J AM COLL CARDIOL
JI J. Am. Coll. Cardiol.
PD OCT 4
PY 2005
VL 46
IS 7
BP 1270
EP 1275
DI 10.1016/j.jacc.2005.06.052
PG 6
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 970NC
UT WOS:000232315900010
PM 16198842
OA Bronze
DA 2025-06-11
ER

PT J
AU Ekhator, C
   Rak, R
   Tadipatri, R
   Fonkem, E
   Grewal, J
AF Ekhator, Chukwuyem
   Rak, Ramin
   Tadipatri, Ramya
   Fonkem, Ekokobe
   Grewal, Jai
TI A Single-Center Experience of Dopamine Antagonist ONC201 for Recurrent
   Histone H3 Lysine 27-to-Methionine (H3K27M)-Mutant Glioblastoma in
   Adults
SO CUREUS JOURNAL OF MEDICAL SCIENCE
LA English
DT Article
DE md anderson symptom inventory instrument (mdasi); karnofsky performance
   scale (kps); h3k27m mutation; onc018; glioblastoma; onc-201
ID ENDOPLASMIC-RETICULUM STRESS; CELL-DEATH; EZH2; PROGRESSION
AB This study aimed to report a single-center experience of three adult subjects receiving ONC201 as part of the ONC018-expanded access clinical trial (NCT03134131). ONC201 is an oral investigational antagonist against the D2 dopamine receptor that has shown encouraging results for malignant gliomas harboring the histone H3 lysine 27-to-methionine (H3K27M) mutation in the H3 histone complex. Responses have been reported in pediatric subjects with such tumors. An expanded access clinical trial (ONC018) was available to eligible patients allowing them access to this agent pending FDA review. Our site enrolled three subjects in the ONC018 trial. We present the demographic, clinical, and molecular characteristics of our enrolled subjects. We report the tolerability, adverse events, and outcome measures including survival, Karnofsky Performance Status (KPS), and quality-of-life measured by the MD Anderson symptom inventory instrument (MDASI). Three subjects were registered at our site onto ONC018 with the age range of 18-44 years, two of three were female, residing in Norway, India, and the United States. Tumor locations were brainstem, corpus callosum, and thalamus. Pathology includes glioblastoma (3/3), methylguanine-DNA methyltransferase (MGMT) methylated (2/3), isocitrate dehydrogenase 1 (IDH1) mutant (0/3), epidermal growth factor receptor (EGFR) amplification (0/3), and alpha thalassemia/mental retardation syndrome X-linked (ATRX) (3/3). Median change from baseline KPS <= 20% decrease; MDASI of 2/3 experienced decrease from baseline (median 6%), consistent with improved quality of life. No clinically significant laboratory abnormalities were found. All adverse events were grades I-II. We found that the study drug was quite tolerable. No serious adverse events nor radiographic responses were seen. Analyses of the larger study cohort and additional randomized controlled trials are necessary to provide insight into the safety and efficacy.
C1 [Ekhator, Chukwuyem] New York Inst Technol Coll Osteopath Med, Neurooncol, Old Westbury, NY 11545 USA.
   [Rak, Ramin] PC NSPC Rockville Ctr, Neurosurg, Neurol Surg, New York, NY USA.
   [Tadipatri, Ramya] Barrow Neurol Inst, Neurol, Phoenix, AZ USA.
   [Fonkem, Ekokobe] Baylor Scott & White Med Ctr, Neurooncol, Temple, TX USA.
   [Grewal, Jai] Mt Sinai South Nassau Hosp, Neurooncol, Oceanside, NY USA.
C3 New York Institute Technology; Barrow Neurological Institute; Baylor
   Health Care System
RP Ekhator, C (corresponding author), New York Inst Technol Coll Osteopath Med, Neurooncol, Old Westbury, NY 11545 USA.
EM chukkiecmd@gmail.com
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NR 41
TC 2
Z9 3
U1 0
U2 0
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
EI 2168-8184
J9 CUREUS J MED SCIENCE
JI Cureus J Med Sci
PD AUG 19
PY 2022
VL 14
IS 8
DI 10.7759/cureus.28175
PG 9
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA 3Y7CY
UT WOS:000843880600024
PM 36148206
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Dennett, EJ
   Janjua, S
   Stovold, E
   Harrison, SL
   McDonnell, MJ
   Holland, AE
AF Dennett, Emma J.
   Janjua, Sadia
   Stovold, Elizabeth
   Harrison, Samantha L.
   McDonnell, Melissa J.
   Holland, Anne E.
TI Tailored or adapted interventions for adults with chronic obstructive
   pulmonary disease and at least one other long-term condition: a mixed
   methods review
SO COCHRANE DATABASE OF SYSTEMATIC REVIEWS
LA English
DT Review
ID CHRONIC HEART-FAILURE; CLINICALLY IMPORTANT DIFFERENCE; RANDOMIZED
   CONTROLLED-TRIAL; MULTIPLE CHRONIC CONDITIONS; HEALTH-CARE
   PROFESSIONALS; SELF-MANAGEMENT; HYPERTENSIVE PATIENTS; CHRONIC ILLNESS;
   BETA-BLOCKERS; DOUBLE-BLIND
AB Background
   Chronic obstructive pulmonary disease (COPD) is a chronic respiratory condition characterised by shortness of breath, cough and recurrent exacerbations. People with COPD often live with one or more co-existing long-term health conditions (comorbidities). People with more severe COPD often have a higher number of comorbidities, putting them at greater risk of morbidity and mortality.
   Objectives
   To assess the effectiveness of any single intervention for COPD adapted or tailored to their comorbidity(s) compared to any other intervention for people with COPD and one or more common comorbidities (quantitative data, RCTs) in terms of the following outcomes: Quality of life, exacerbations, functional status, all-cause and respiratory-related hospital admissions, mortality, pain, and depression and anxiety.
   To assess the effectiveness of an adapted or tailored single COPD intervention (simple or complex) that is aimed at changing the management of people with COPD and one or more common comorbidities (quantitative data, RCTs) compared to usual care in terms of the following outcomes: Quality of life, exacerbations, functional status, all-cause and respiratory-related hospital admissions, mortality, pain, and depression and anxiety.
   To identify emerging themes that describe the views and experiences of patients, carers and healthcare professionals when receiving or providing care to manage multimorbidities (qualitative data).
   Search methods
   We searched multiple databases including the Cochrane Airways Trials Register, CENTRAL, MEDLINE, Embase, and CINAHL, to identify relevant randomised and qualitative studies. We also searched trial registries and conducted citation searches. The latest search was conducted in January 2021.
   Selection criteria
   Eligible randomised controlled trials (RCTs) compared a) any single intervention for COPD adapted or tailored to their comorbidity(s) compared to any other intervention, orb) any adapted or tailored single COPD intervention (simple or complex) that is aimed at changing the management of people with COPD and one or more comorbidities, compared to usual care. We included qualitative studies or mixed-methods studies to identify themes.
   Data collection and analysis
   We used standard Cochrane methods for analysis of the RCTs. We used Cochrane's risk of bias tool for the RCTs and the CASP checklist for the qualitative studies. We planned to use the Mixed Methods Appraisal tool (MMAT) to assess the risk of bias in mixed-methods studies, but we found none. We used GRADE and CERQual to assess the quality of the quantitative and qualitative evidence respectively. The primary outcome measures for this review were quality of life and exacerbations.
   Main results
   Quantitative studies
   We included seven studies (1197 participants) in the quantitative analyses, with interventions including telemonitoring, pulmonary rehabilitation, treatment optimisation, water-based exercise training and case management. Interventions were either compared with usual care or with an active comparator (such as land-based exercise training). Duration of trials ranged from 4 to 52 weeks. Mean age of participants ranged from 64 to 72 years and COPD severity ranged from mild to very severe. Trials included either people with COPD and a specific comorbidity (including cardiovascular disease, metabolic syndrome, lung cancer, head or neck cancer, and musculoskeletal conditions), or with one or more comorbidities of any type.
   Overall, we judged the evidence presented to be of moderate to very low certainty (GRADE), mainly due to the methodological quality of included trials and imprecision of effect estimates.
   Intervention versus usual care
   Quality of life as measured by the St George's Respiratory Questionnaire (SGRQ) total score may improve with tailored pulmonary rehabilitation compared to usual care at 52 weeks (mean difference (MD) -10.85, 95% confidence interval (CI) -12.66 to -9.04; 1 study, 70 participants; low-certainty evidence). Tailored pulmonary rehabilitation is likely to improve COPD assessment test (CAT) scores compared with usual care at 52 weeks (MD -8.02, 95% CI -9.44 to -6.60; 1 study, 70 participants, moderate-certainty evidence) and with a multicomponent telehealth intervention at 52 weeks (M D -6.90, 95% CI -9.56 to -4.24; moderate-certainty evidence). Evidence is uncertain about effects of pharmacotherapy optimisation or telemonitoring interventions on CAT improvement compared with usual care.
   There may be little to no difference in the number of people experiencing exacerbations, or mean exacerbations with case management compared with usual care (OR 1.09, 95% CI 0.75 to 1.57; 1 study, 470 participants; very low-certainty evidence).
   For secondary outcomes, six-minute walk distance (6MWD) may improve with pulmonary rehabilitation, water-based exercise or multicomponent interventions at 38 to 52 weeks (low-certainty evidence). A multicomponent intervention may result in fewer people being admitted to hospital at 17 weeks, although there may be little to no difference in a telemonitoring intervention. There may be little to no difference between intervention and usual care for mortality.
   Intervention versus active comparator
   We included one study comparing water-based and land-based exercise (30 participants). We found no evidence for quality of life or exacerbations.
   There may be little to no difference between water- and land-based exercise for 6MWD (MD 5 metres, 95% CI -22 to 32; 38 participants; very low-certainty evidence).
   Qualitative studies
   One nested qualitative study (21 participants) explored perceptions and experiences of people with COPD and long-term conditions, and of researchers and health professionals who were involved in an RCT of telemonitoring equipment.
   Several themes were identified, including health status, beliefs and concerns, reliability of equipment, self-efficacy, perceived ease of use, factors affecting usefulness and perceived usefulness, attitudes and intention, self-management and changes in healthcare use. We judged the qualitative evidence presented as of very low certainty overall.
   Authors' conclusions
   Owing to a paucity of eligible trials, as well as diversity in the intervention type, comorbidities and the outcome measures reported, we were unable to provide a robust synthesis of data. Pulmonary rehabilitation or multicomponent interventions may improve quality of life and functional status (6MWD), but the evidence is too limited to draw a robust conclusion. The key take-home message from this review is the lack of data from RCTs on treatments for people living with COPD and comorbidities.
   Given the variation in number and type of comorbidity(s) an individual may have, and severity of COPD, larger studies reporting individual patient data are required to determine these effects.
C1 [Dennett, Emma J.; Janjua, Sadia; Stovold, Elizabeth] St Georges Univ London, Populat Hlth Res Inst, Cochrane Airways, London, England.
   [Harrison, Samantha L.] Teesside Univ, Sch Hlth & Social Care, Middlesbrough, Cleveland, England.
   [McDonnell, Melissa J.] Galway Univ Hosp, Dept Resp Med, Galway, Ireland.
   [Holland, Anne E.] Alfred Hlth, Physiotherapy, Melbourne, Vic, Australia.
   [Holland, Anne E.] La Trobe Univ, Sch Allied Hlth Human Serv & Sport, Discipline Physiotherapy, Melbourne, Vic, Australia.
   [Holland, Anne E.] Inst Breathing & Sleep, Melbourne, Vic, Australia.
C3 City St Georges, University of London; St Georges University London;
   University of Teesside; Ollscoil na Gaillimhe-University of Galway;
   Alfred Health; La Trobe University; Institute for Breathing & Sleep
   (IBAS)
RP Dennett, EJ (corresponding author), St Georges Univ London, Populat Hlth Res Inst, Cochrane Airways, London, England.
EM edennett@sgul.ac.uk
RI Stovold, Elizabeth/L-6981-2019; Holland, Anne/AAB-3055-2019; Dennett,
   Emma/ABD-1420-2021
OI Harrison, Samantha/0000-0002-8871-781X; Stovold,
   Elizabeth/0000-0002-5405-7737
FU National Institute for Health Research, UK; Cochrane Programme Grant
   [16/114/21]
FX National Institute for Health Research, UKCochrane Programme Grant
   16/114/21: NHS priorities in the management of chronic respiratory
   disease
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NR 323
TC 19
Z9 19
U1 2
U2 37
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1469-493X
EI 1361-6137
J9 COCHRANE DB SYST REV
JI Cochrane Database Syst Rev.
PY 2021
IS 7
AR CD013384
DI 10.1002/14651858.CD013384.pub2
PG 114
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA TS9QE
UT WOS:000679985300009
PM 34309831
OA Green Published, Green Accepted
DA 2025-06-11
ER

PT J
AU Eslami, L
   Merat, S
   Malekzadeh, R
   Nasseri-Moghaddam, S
   Aramin, H
AF Eslami, Layli
   Merat, Shahin
   Malekzadeh, Reza
   Nasseri-Moghaddam, Siavosh
   Aramin, Hermineh
TI Statins for non-alcoholic fatty liver disease and non-alcoholic
   steatohepatitis
SO COCHRANE DATABASE OF SYSTEMATIC REVIEWS
LA English
DT Review
ID ENDOPLASMIC-RETICULUM STRESS; CONTROLLED-TRIALS; HYPERCHOLESTEROLEMIC
   PATIENTS; DESIGN CHARACTERISTICS; METABOLIC SYNDROME;
   EMPIRICAL-EVIDENCE; RANDOMIZED-TRIALS; EFFICACY; ATORVASTATIN; QUALITY
AB Background
   Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are common causes of elevated liver enzymes in the general population. NASH and to some extent NAFLD have been associated with increased liver-related and all-cause mortality. No effective treatment is yet available. Recent reports have shown that the use of hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors (statins) in patients with elevated plasma aminotransferases may result in normalisation of these liver enzymes. Whether this is a consistent effect or whether it can lead to improved clinical outcomes beyond normalisation of abnormal liver enzymes is not clear.
   Objectives
   To assess the beneficial and harmful effects of statins (that is, lovastatin, atorvastatin, simvastatin, pravastatin, rosuvastatin, and fluvastatin) on all-cause and liver-related mortality, adverse events, and histological, biochemical, and imaging responses in patients with NAFLD or NASH.
   Search methods
   We performed a computerised literature search in the Cochrane Hepato-Biliary Group Controlled Trials Register, Cochrane Central Register of Controlled Trials (CENTRAL) in The Cochrane Library, MEDLINE, EMBASE, and Science Citation Index Expanded up to March 2013. We did fully recursive searches from the reference lists of all retrieved relevant publications to ensure a complete and comprehensive search of the published literature. We did not apply any restrictions regarding language of publication or publication date.
   Selection criteria
   All randomised clinical trials using statins as the primary treatment for NAFLD or NASH versus no treatment, placebo, or other hypolipidaemic agents.
   Data collection and analysis
   Data were extracted, and risk of bias of each trial was assessed independently by two or more review authors. Meta-analyses were performed whenever possible. Review Manager 5.2 was used.
   Main results
   When the described search method was used and the eligibility criteria of the search results were applied, 653 records were found. Only two of these were randomised clinical trials that were considered eligible for inclusion. We assessed both trials as trials with high risk of bias. One of the trials was a pilot trial in which 16 participants with biopsy-proven NASH were randomised to receive simvastatin 40 mg (n = 10) or placebo (n = 6) once daily for 12 months. No statistically significant improvement in the aminotransferase level was seen in the simvastatin group compared with the placebo group. Liver histology was not significantly affected by simvastatin.
   The other trial had three arms. The trial compared atorvastatin 20 mg daily (n = 63) versus fenofibrate 200 mg daily (n = 62) versus a group treated with a combination of the two interventions (n = 61). There were no statistically significant differences between any of the three intervention groups regarding the week 54 mean activity levels of aspartate aminotransferase, alanine aminotransferase, gamma-glutamyl transpeptidase, and alkaline phosphatase. The triglyceride levels seemed higher in the fenofibrate group compared with the atorvastatin group. Liver histology was not assessed in this trial. The presence of biochemical and ultrasonographic evidence of NAFLD seemed to be higher in the fenofibrate group compared with the atorvastatin group (58% versus 33%). Three patients discontinued treatment due to myalgia and elevated serum creatine kinase activity; one from the atorvastatin group and two from the combination group. Another patient from the atorvastatin group discontinued treatment due to alanine aminotransferase activity that was over three times the upper normal limit.
   No data for all-cause mortality and hepatic-related mortality were reported in the included trials.
   Authors' conclusions
   Based on the findings of this review, which included two trials with high risk of bias and a small numbers of participants, it seems possible that statins may improve serum aminotransferase levels as well as ultrasound findings. Neither of the trials reported on possible histological changes, liver-related morbidity or mortality. Trials with larger sample sizes and low risk of bias are necessary before we may suggest statins as an effective treatment for patients with NASH. However, as statins can improve the adverse outcomes of other conditions commonly associated with NASH (for example, hyperlipidaemia, diabetes mellitus, metabolic syndrome), their use in patients with non-alcoholic steatohepatitis may be justified.
C1 [Eslami, Layli] Golestan Univ Med Sci, Taleghani Hosp, Gonbad 4979131983, Golestan Provin, Iran.
   [Eslami, Layli] Golestan Univ Med Sci, Taleghani Hosp, Kavous 4979131983, Golestan Provin, Iran.
   [Merat, Shahin; Malekzadeh, Reza; Nasseri-Moghaddam, Siavosh; Aramin, Hermineh] Univ Tehran Med Sci, Shariati Hosp, Digest Dis Res Ctr, Tehran, Iran.
C3 Golestan University of Medical Sciences; Golestan University of Medical
   Sciences; Tehran University of Medical Sciences
RP Eslami, L (corresponding author), Golestan Univ Med Sci, Taleghani Hosp, North Khayyam Crossrd,East Taleghani Ave, Gonbad 4979131983, Golestan Provin, Iran.
EM laylieslami@gmail.com
RI Malekzadeh, Reza/U-1382-2017; Merat, Shahin/A-5478-2009
OI Merat, Shahin/0000-0002-8088-6723; Malekzadeh, Reza/0000-0003-1043-3814
FU Tehran University of Medical Sciences (TUMS), Iran
FX Internal sourcesTehran University of Medical Sciences (TUMS), Iran.
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NR 61
TC 119
Z9 125
U1 0
U2 18
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1469-493X
EI 1361-6137
J9 COCHRANE DB SYST REV
JI Cochrane Database Syst Rev.
PY 2013
IS 12
AR CD008623
DI 10.1002/14651858.CD008623.pub2
PG 25
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 282QW
UT WOS:000329188500010
PM 24374462
DA 2025-06-11
ER

PT J
AU Jain, SK
   Justin Margret, J
   Zachary, A
   Lally, MM
   Vanchiere, JA
   Mhanna, MJ
   Shi, R
   Levine, SN
AF Jain, Sushil K.
   Justin Margret, Jeffrey
   Zachary, Alonzo
   Lally, Marissa M.
   Vanchiere, John A.
   Mhanna, Maroun J.
   Shi, Runhua
   Levine, Steven N.
TI Effects of vitamin D and L-cysteine cosupplementation on circulating
   bioavailable and total 25-hydroxy-vitamin D, the free/total testosterone
   ratio and inflammatory biomarkers in healthy vitamin D-deficient African
   Americans: a placebo-controlled double-blind clinical trial
SO BMJ NUTRITION, PREVENTION & HEALTH
LA English
DT Article
DE Nutritional treatment; Biomarker
ID D-BINDING PROTEIN; 25-HYDROXYVITAMIN D; HIGH-GLUCOSE; SUPPLEMENTATION;
   MEN; POPULATION; BLOOD
AB Background Subjects with metabolic syndrome and obesity have higher levels of inflammation with depression of the vitamin D (VD) hydroxylase/metabolising genes (CYP2R1/CYP27A1/CYP27B1/VDR) required to convert VD consumed in the diet into 25(OH)VD. Compared with total 25(OH)VD levels, measurement of bioavailable 25(OH)VD is a better method to determine the beneficial effect of VD.
   Objective This study investigates whether cosupplementation with VD and L-cysteine (LC), which downregulates inflammation and upregulates VD-regulating genes, provides a better therapeutic benefit than supplementation with VD-alone in African Americans (AA).
   Methods AA participants (men/women, aged 18-65 years; n=165) were block randomised into one of four groups and received daily, oral supplementation for 6 months with placebo, LC (1000 mg/day), VD (2000 IU/day) or VD+LC. Fasting blood collected at the baseline and final visits was analysed for total, free and bioavailable 25(OH)VD along with insulin, VD-binding protein (VDBP), sex hormone-binding globulin (SHBG), free and total testosterone, and inflammatory marker levels. Studies were carried out in THP-1 monocytes to elucidate the direct effect of LC and testosterone on VD-regulating genes.
   Results Baseline data showed no differences in age, body mass index, calcium, liver or kidney function among the groups. Compared with levels in the group that received VD-alone supplementation, levels of neutrophil-to-lymphocyte ratio, C reactive protein, HOMA-IR, VDBP and HbA1c were significantly lower in the VD+LC group while the VD+LC group showed a significant increase in bioavailable 25(OH)VD in both sexes, total 25(OH)VD levels were significantly elevated in men but not in women treated with VD+LC. Blood levels of SHBG and free/total testosterone were elevated in the VD+LC group but not in the VD-alone group. LC and testosterone treatment significantly upregulated VD-metabolising genes (CYP2R1/CYP27A1/CYP27B1/VDR) and SHBG in THP-1 monocytes.
   Conclusions VD cosupplemented with LC upregulates circulating bioavailable 25(OH)VD and reduces inflammation. Total 25(OH)VD levels were higher in men but not in women in the VD+LC group. This pilot study suggests that compared with supplementation with VD-alone, VD+LC cosupplementation could be a better approach to raising the total 25(OH)VD in men and the bioavailable 25(OH)VD in both sexes and lowering the inflammatory risk in the AA population.
C1 [Jain, Sushil K.; Justin Margret, Jeffrey; Zachary, Alonzo; Lally, Marissa M.; Vanchiere, John A.; Mhanna, Maroun J.] Louisiana State Univ, Dept Pediat, Hlth Sci Ctr, Shreveport, LA 70112 USA.
   [Shi, Runhua; Levine, Steven N.] Louisiana State Univ, Dept Med, Hlth Sci Ctr, Shreveport, LA USA.
C3 Louisiana State University System; Louisiana State University Health
   Sciences Center at Shreveport; Louisiana State University System;
   Louisiana State University Health Sciences Center at Shreveport
RP Jain, SK (corresponding author), Louisiana State Univ, Dept Pediat, Hlth Sci Ctr, Shreveport, LA 70112 USA.
EM sushil.jain@lsuhs.edu
RI Vanchiere, John/AAD-8979-2019; Justin Margret, Jeffrey/GRF-1738-2022
OI Jain, Sushil/0000-0002-9574-0436
FU NIH/NCCIH [5R33AT010637, AT010637-02S1]; Malcolm Feist Endowed Chair in
   Diabetes
FX The authors are supported by grants from NIH/NCCIH (5R33AT010637 and
   3R33 AT010637-02S1) and the Malcolm Feist Endowed Chair in Diabetes.
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NR 40
TC 2
Z9 2
U1 0
U2 1
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
EI 2516-5542
J9 BMJ NUTR PREV HLTH
JI BMJ Nutr. Prev. Health
PD DEC
PY 2024
VL 7
IS 2
BP 230
EP 239
DI 10.1136/bmjnph-2023-000856
EA JUL 2024
PG 10
WC Nutrition & Dietetics
WE Emerging Sources Citation Index (ESCI)
SC Nutrition & Dietetics
GA U0U7M
UT WOS:001288625500001
PM 39882299
OA gold
DA 2025-06-11
ER

PT J
AU Cahoon, D
   Shertukde, SP
   Avendano, EE
   Tanprasertsuk, J
   Scott, TM
   Johnson, EJ
   Chung, M
   Nirmala, N
AF Cahoon, Danielle
   Shertukde, Shruti P.
   Avendano, Esther E.
   Tanprasertsuk, Jirayu
   Scott, Tammy M.
   Johnson, Elizabeth J.
   Chung, Mei
   Nirmala, Nanguneri
TI Walnut intake, cognitive outcomes and risk factors: a systematic review
   and meta-analysis
SO ANNALS OF MEDICINE
LA English
DT Review
DE Walnut; cognition; cognitive decline; mood; depression; stroke;
   inflammation; HbA1c; HOMA-IR; glucose metabolism
ID HEALTHY CAUCASIAN SUBJECTS; SMALL VESSEL DISEASE; ENDOTHELIAL FUNCTION;
   METABOLIC SYNDROME; ANTIOXIDANT CAPACITY; MEDITERRANEAN DIET;
   HDL-CHOLESTEROL; NUT CONSUMPTION; HIGH CASHEW; CROSSOVER
AB Background
   Walnuts contain nutrients that are associated with improved cognitive health. To our knowledge, no review has systematically examined the effects of walnuts on cognitive function and risk for cognitive decline.
   Objective
   To conduct a systematic review and meta-analysis evaluating the effects of walnut intake on cognition-related outcomes and risk-factors for cognitive decline in adults.
   Methods
   Medline(R), Commonwealth Agricultural Bureau, and Cochrane Central Register of Controlled Trials were searched for randomized controlled trials (RCTs) and observational studies published until April 2020 on walnut intake, cognition (e.g. cognitive function, stroke, and mood), and selected risk factors for cognitive decline (e.g. glucose homeostasis and inflammation). Risk-of-bias and strength-of-evidence assessments were conducted using standard validated tools. Random-effects meta-analyses were conducted when >= 3 studies reported quantitative data for each outcome.
   Results
   32 RCT and 7 observational study publications were included. Meta-analysis of cognition-related outcomes could not be conducted due to heterogeneity of tests. None of the 5 cognition RCTs found significant effects of walnuts on overall cognition, although 3 studies found improvements on subdomains and/or subgroups. All 7 observational studies found significant associations and a dose-response relationship between walnut intake and cognition-related outcomes. Meta-analyses of 27 RCTs reporting glucose homeostasis and inflammation outcomes, selected risk factors for cognitive decline, did not show significant effects of walnut intake.
   Conclusions
   Due to the non-uniformity of tests for cognition-related outcomes, definitive conclusions regarding the effect of walnut consumption on cognition could not be reached. Additionally, evidence does not show associations between walnut intake and glucose homeostasis or inflammation, cognitive decline risk-factors. High-quality studies with standardized measures are needed to clarify the role of walnuts in cognitive health. KEY MESSAGES
   This is a systematic review and meta-analysis of 5 randomized clinical trials and 7 observational study articles of the impact of walnut intake on cognition decline and 27 randomized clinical trials of the effect of walnut intake on risk factors for cognitive decline including glucose homeostasis and inflammation.
   The non-uniformity of tests performed to measure cognitive function in the various studies did not allow for a meta-analysis of these studies. A definitive conclusion could therefore not be reached regarding the effect of walnut intake on cognitive decline.
   The evidence available does not show an association between walnut intake and glucose homeostasis or inflammation.
C1 [Cahoon, Danielle; Shertukde, Shruti P.; Tanprasertsuk, Jirayu; Scott, Tammy M.; Johnson, Elizabeth J.; Chung, Mei] Tufts Univ, Gerald J & Dorothy R Friedman Sch Nutr Sci & Poli, Boston, MA 02111 USA.
   [Avendano, Esther E.; Chung, Mei] Tufts Univ, Sch Med, Dept Publ Hlth & Community Med, Boston, MA 02111 USA.
   [Nirmala, Nanguneri] Tufts Med Ctr, Inst Clin Res & Hlth Policy Studies, Ctr Clin Evidence Synth, Boston, MA 02111 USA.
C3 Tufts University; Tufts University; Massachusetts Department of Public
   Health; Tufts Medical Center
RP Nirmala, N (corresponding author), Tufts Med Ctr, Inst Clin Res & Hlth Policy Studies, Ctr Clin Evidence Synth, Boston, MA 02111 USA.
EM nnirmala@tuftsmedicalcenter.org
RI Tanprasertsuk, Jirayu/AAR-1538-2020
OI Tanprasertsuk, Jirayu/0000-0001-6203-3797; Nirmala,
   Nanguneri/0000-0003-0267-9793
FU California Walnut Commission
FX The California Walnut Commission funded this work.
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NR 81
TC 14
Z9 17
U1 1
U2 26
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0785-3890
EI 1365-2060
J9 ANN MED
JI Ann. Med.
PD JAN 1
PY 2021
VL 53
IS 1
BP 971
EP 997
DI 10.1080/07853890.2021.1925955
PG 27
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA ST1YF
UT WOS:000662246100001
PM 34132152
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Chengappa, KNR
   Kupfer, DJ
   Parepally, H
   John, V
   Basu, R
   Buttenfield, J
   Schlicht, P
   Houck, P
   Brar, JS
   Gershon, S
AF Chengappa, K. N. Roy
   Kupfer, David J.
   Parepally, Haranath
   John, Vineeth
   Basu, Ranita
   Buttenfield, Joan
   Schlicht, Patricia
   Houck, Patricia
   Brar, Jaspreet S.
   Gershon, Samuel
TI A placebo-controlled, random-assignment, parallel-group pilot study of
   adjunctive topiramate for patients with schizoaffective disorder,
   bipolar type
SO BIPOLAR DISORDERS
LA English
DT Article
DE bipolar type; body mass index; body weight; clinical trial; placebo;
   schizoaffective disorder; topiramate
ID DOUBLE-BLIND; METABOLIC SYNDROME; RATING-SCALE; ACUTE MANIA; EFFICACY;
   LITHIUM; RELIABILITY; HALOPERIDOL; COMBINATION; MANAGEMENT
AB Objectives: This pilot study evaluated the efficacy and safety of adjunctive topiramate compared with placebo in the treatment of patients with a diagnosis of schizoaffective disorder, bipolar type (SAD-BT).
   Methods:A sample of 48 adult patients with a Diagnostic and Statistical Manual of Mental Disorders, 4th Edition, Text Revision (DSM-IV-TR) diagnosis of SAD-BT (supported by the Structured Clinical Interview for DSM-IV Axis I Disorder, Patient Edition) were randomly assigned in a 2:1 ratio (favoring topiramate) to 8 weeks of double-blind treatment with topiramate (100-400 mg/day) or placebo. Patients who had achieved a >= 20% decrease from baseline in their Positive and Negative Syndrome Scale (PANSS) total scores were given the opportunity to continue for an additional 8 weeks of double-blind treatment. The dosage of the study medicine was continued unchanged from the earlier 8-week study period. At the end of the study period, the study medicine was tapered and discontinued over a 2-week period. Primary efficacy was assessed at 8 weeks using the mean change between treatment groups of the PANSS total scores in the intent-to-treat population of randomized patients. Several secondary measures were also assessed. Safety analyses included monitoring of adverse events, vital signs, electrocardiogram (ECG) and laboratory values.
   Results:Even though both treatments reduced scores on various psychopathology rating scales, adjunctive topiramate treatment (nearly 275 mg/day) did not show increased efficacy relative to placebo on the primary outcome measure (PANSS scale) or any of the secondary outcome measures. Topiramate-treated patients lost significantly more body weight than placebo-treated patients, which led to a significant reduction in body mass index (BMI). Relative to adjunctive placebo, topiramate-treated patients experienced higher rates of paresthesia, sedation, word-finding difficulty, sleepiness, and forgetfulness, but these differences were not statistically significant. There were no clinically significant abnormalities in either the ECG or laboratory results. There were no serious adverse events in the study. Further, there was no worsening of the PANSS total scores (to >= 10% from baseline), and no significant differences between the treatments on worsening of total Montgomery-Asberg Depression Rating Scale (MADRS) scores [1/13 (7.7%) for placebo; 1/25 (4.0%) for topiramate].
   Conclusions:This pilot study did not support clinical efficacy for adjunctive topiramate treatment in patients with SAD-BT. There were no major safety or tolerability issues in this study. Confirming the results of other studies, topiramate-treated patients did experience greater body weight loss and reduction in BMI.
C1 Univ Pittsburgh, Sch Med, Western Psychiat Inst & Clin, Pittsburgh, PA 15260 USA.
   Mayview State Hosp, Pittsburgh, PA USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE); University
   of Pittsburgh; Western Psychiatric Institute & Clinic of UPMC
RP Chengappa, KNR (corresponding author), Western Psychiat Inst & Clin, 3811 OHara St, Pittsburgh, PA 15213 USA.
EM chengappakn@upmc.edu
RI Brar, Jaspreet/J-7816-2019
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NR 30
TC 30
Z9 30
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1398-5647
EI 1399-5618
J9 BIPOLAR DISORD
JI Bipolar Disord.
PD SEP
PY 2007
VL 9
IS 6
BP 609
EP 617
DI 10.1111/j.1399-5618.2007.00506.x
PG 9
WC Clinical Neurology; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Psychiatry
GA 207TY
UT WOS:000249275200008
PM 17845276
DA 2025-06-11
ER

PT J
AU Guan, ZF
   Zhou, XL
   Zhang, XM
   Zhang, Y
   Wang, YM
   Guo, QL
   Ji, G
   Wu, GF
   Wang, NN
   Yang, H
   Yu, ZY
   Zhou, HG
   Guo, JC
   Liu, YC
AF Guan, Zhu-Fei
   Zhou, Xiu-Ling
   Zhang, Xiao-Ming
   Zhang, Yu
   Wang, Yan-Mei
   Guo, Qi-Lin
   Ji, Gang
   Wu, Guo-Feng
   Wang, Na-Na
   Yang, Hao
   Yu, Zhong-Yu
   Zhou, Hou-Guang
   Guo, Jing-Chun
   Liu, Ying-Chao
TI Beclin-1-mediated autophagy may be involved in the elderly cognitive and
   affective disorders in streptozotocin-induced diabetic mice
SO TRANSLATIONAL NEURODEGENERATION
LA English
DT Article
ID NF-KAPPA-B; ALZHEIMER-DISEASE; MITOCHONDRIAL AUTOPHAGY; NERVOUS-SYSTEM;
   NITRIC-OXIDE; MELLITUS; CELLS; RAT; ENCEPHALOPATHY; INTERVENTION
AB Background: Diabetes is the most common metabolic disease with many chronic complications, and cognitive disorders are one of the common complications in patients with diabetes. Previous studies have showed that autophagy played important roles in the progression of metabolic syndrome, diabetes and other diseases. So we investigated whether aged diabetic mice are prone to be associated with the cognitive and affective disorders and whether Beclin-1-mediated autophagy might be involved in thepahological process.
   Methods: High-fat diet/streptozotocin (STZ) injection-induced diabetic C57 mice were adopted in this study. Cognitive disorders were detected by Morris water maze and fear conditional test. Affective disorders were detected by tail suspension test and forced swimming test. Magnetic resonance imaging was applied to observe changes of morphology and metabolism in the brain. The F-18-fluorodeoxyglucose positron emission tomography (FDG-PET) was used to assess metabolism changes in the brain of aged diabetic mice. Autophagy were evaluated by Beclin-1, LC3II/I and P62, which were detected by western blot analysis and observed by electron microscopy.
   Results: 1. Compared with control group, diabetes mice showed significantly decreasing abilities in spatial memory and conditioned fear memory (all P < 0.05), and increasing tendency of depression (P < 0.05). 2. MRI showed that the majority of elderly diabetic mice were associated with multiple cerebral small vessel disease. Some even showed hippocampal atrophy, ventricular dilatation and leukoaraiosis. 3. FDG-PET-CT discovered that the glucose metabolism in the amygdala and hippocampus was significantly decreased compared with normal aged mice (P < 0.05). 4. Electron microscopy found that, although autophagy bodies was not widespread, and there was no significant difference between the two groups, yet compared with normal aged mice, apparent cell edema, myelinated tow reduction and intracellular lipofuscin augmentation existed in elderly diabetic mice brain. 5. The level of p62 was increased in the STZ-induced diabetic mice hippocampus and striatum, and beclin1 protein expression were significantly decreased in diabetic mice hippocampus compared with normal aged mice (P < 0.05). There was a upward trend of the ratio of LC3II/I in hippocampus, cortex and striatum, but no statistically difference between the two groups.
   Conclusion: Compared with normal aged mice, diabetic aged mice were apt to cerebral small vessel disease and associated with cognitive and affective disorders, which may be related to the significantly reduced glucose metabolism in hippocampus and amygdala. Beclin1 mediated autophagy in hippocampus probably played an important role in cognitive and affective disorders of STZ-induced aged diabetic mice.
C1 [Guan, Zhu-Fei; Zhang, Xiao-Ming; Zhang, Yu; Wang, Yan-Mei; Wang, Na-Na; Yang, Hao; Yu, Zhong-Yu; Zhou, Hou-Guang] Fudan Univ, Huashan Hosp, Dept Geriatr Neurol, Natl Clin Med Res Ctr Age Related Dis, 12 Middle WuLuMuQi Rd, Shanghai 200040, Peoples R China.
   [Guan, Zhu-Fei; Guo, Qi-Lin; Ji, Gang; Guo, Jing-Chun] Fudan Univ, State Key Lab Med Neurobiol, Dept Neurobiol,Shanghai Med Coll, Sch Basic Med Neurobiol,Sch Basic Med Sci, 131 DongAn Rd, Shanghai 200032, Peoples R China.
   [Zhou, Xiu-Ling] Fudan Univ, Huashan Hosp, Dept Ultrason, Shanghai 200040, Peoples R China.
   [Wu, Guo-Feng] Guiyang Med Univ, Dept Emergency Neurol, Guiyang 550004, Peoples R China.
   [Liu, Ying-Chao] Shandong Prov Hosp, Dept Neurosurg, 5 Latitude & 7 Longitude Rd, Jinan 250021, Peoples R China.
C3 Fudan University; Fudan University; Fudan University; Guizhou Medical
   University; Shandong First Medical University & Shandong Academy of
   Medical Sciences
RP Zhou, HG (corresponding author), Fudan Univ, Huashan Hosp, Dept Geriatr Neurol, Natl Clin Med Res Ctr Age Related Dis, 12 Middle WuLuMuQi Rd, Shanghai 200040, Peoples R China.; Guo, JC (corresponding author), Fudan Univ, State Key Lab Med Neurobiol, Dept Neurobiol,Shanghai Med Coll, Sch Basic Med Neurobiol,Sch Basic Med Sci, 131 DongAn Rd, Shanghai 200032, Peoples R China.; Liu, YC (corresponding author), Shandong Prov Hosp, Dept Neurosurg, 5 Latitude & 7 Longitude Rd, Jinan 250021, Peoples R China.
EM zhg7376@163.com; jingchunguo@shmu.edu.cn; fdlyc@aliyun.com
RI Yang, Hao/MAH-8089-2025
OI Guo, Qilin/0000-0002-7531-0818
FU National Natural Scientific Foundation, China [81170322, 81571361,
   U1632120]; Shanghai Natural Scientific Foundation, China [11ZR1405300];
   Shanghai Municipal Outstanding Talent Development Foundation [2012052]
FX This work was supported by grants from the National Natural Scientific
   Foundation, China (81170322, 81571361, U1632120), Shanghai Natural
   Scientific Foundation, China (11ZR1405300), and Shanghai Municipal
   Outstanding Talent Development Foundation (2012052).
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NR 51
TC 46
Z9 49
U1 1
U2 33
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 2047-9158
J9 TRANSL NEURODEGENER
JI Transl. Neurodegener.
PD DEC 12
PY 2016
VL 5
AR 22
DI 10.1186/s40035-016-0070-4
PG 10
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA EG0JE
UT WOS:000390717200001
PM 27999666
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Vinuesa, A
   Pomilio, C
   Menafra, M
   Bonaventura, MM
   Garay, L
   Mercogliano, MF
   Schillaci, R
   Lantos, VL
   Brites, F
   Beauquis, J
   Saravia, F
AF Vinuesa, Angeles
   Pomilio, Carlos
   Menafra, Martin
   Marta Bonaventura, Maria
   Garay, Laura
   Florencia Mercogliano, Maria
   Schillaci, Roxana
   Lux Lantos, Victoria
   Brites, Fernando
   Beauquis, Juan
   Saravia, Flavia
TI Juvenile exposure to a high fat diet promotes behavioral and limbic
   alterations in the absence of obesity
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE High fat diet; Hippocampal neuroinflammation; Neurogenesis;
   Periadolescence; Cognitive performance; Emotionality
ID HIPPOCAMPAL NEUROGENESIS; GLIAL ALTERATIONS; NESTING-BEHAVIOR; SPATIAL
   MEMORY; BRAIN; MODEL; AGE; IMPAIRMENT; NEUROINFLAMMATION; DEPRESSION
AB The incidence of metabolic disorders including obesity, type 2 diabetes and metabolic syndrome have seriously increased in the last decades. These diseases - with growing impact in modern societies constitute major risk factors for neurodegenerative disorders such as Alzheimer's disease (AD), sharing insulin resistance, inflammation and associated cognitive impairment. However, cerebral cellular and molecular pathways involved are not yet clearly understood. Thus, our aim was to study the impact of a non-severe high fat diet (HFD) that resembles western-like alimentary habits, particularly involving juvenile stages where the brain physiology and connectivity are in plain maturation. To this end, one month-old C57BL/6J male mice were given either a control diet or HFD during 4 months. Exposure to HFD produced metabolic alterations along with changes in behavioral and central parameters, in the absence of obesity. Two-month-old HFD mice showed increased glycemia and plasmatic IL1 beta but these values normalized at the end of the HFD protocol at 5 months of age, probably representing an acute response that is compensated at later stages. After four months of HFD exposure, mice presented dyslipidemia, increased Lipoprotein-associated phospholipase A2 (Lp-PLA2) activity, hepatic insulin resistance and inflammation. Alterations in the behavioral profile of the HFD group were shown by the impediment in nest building behavior, deficiencies in short and mid-term spatial memories, anxious and depressive like behavior. Regarding the latter disruptions in emotional processing, we found an increased neural activity in the amygdala, shown by a greater number of c-Fos+ nuclei. We found that hippocampal adult neurogenesis was decreased in HFD mice, showing diminished cell proliferation measured as Ki67+ cells and neuronal differentiation in SGZ by doublecortin labeling. These phenomena were accompanied by a neuroinflammatory and insulin-resistant state in the hippocampus, depicted by a reactive phenotype in Iba1+ microglia cells (increased in number and soma size) and an impaired response to insulin given by decreased phosphorylated Akt levels and increased levels of inhibitory phosphorylation of IRS1. Our data portray a set of alterations in behavioral and neural parameters as a consequence of an early-life exposure to a quite moderate high fat diet, many of which can resemble AD-related features. These results highly emphasize the need to study how metabolic and neurodegenerative disorders are interrelated in deep, thus allowing the finding of successful preventive and therapeutic approaches. (C) 2016 Elsevier Ltd. All rights reserved.
C1 [Vinuesa, Angeles; Pomilio, Carlos; Beauquis, Juan; Saravia, Flavia] Univ Buenos Aires, Fac Ciencias Exactas & Nat, Dept Quim Biol, Neurobiol Aging, RA-1053 Buenos Aires, DF, Argentina.
   [Vinuesa, Angeles; Pomilio, Carlos; Marta Bonaventura, Maria; Garay, Laura; Florencia Mercogliano, Maria; Schillaci, Roxana; Lux Lantos, Victoria; Beauquis, Juan; Saravia, Flavia] Consejo Nacl Invest Cient & Tecn, Inst Biol & Med Expt, Buenos Aires, DF, Argentina.
   [Menafra, Martin; Brites, Fernando] Univ Buenos Aires, Fac Farm & Bioquim, Buenos Aires, DF, Argentina.
C3 University of Buenos Aires; Consejo Nacional de Investigaciones
   Cientificas y Tecnicas (CONICET); Institute of Biology & Experimental
   Medicine; University of Buenos Aires
RP Saravia, F (corresponding author), Univ Buenos Aires, Fac Ciencias Exactas & Nat, CONICET, Inst Biol & Med Expt, Obligado 2490, RA-1428 Buenos Aires, DF, Argentina.; Saravia, F (corresponding author), Univ Buenos Aires, Fac Ciencias Exactas & Nat, Dept Quim Biol, RA-1428 Buenos Aires, DF, Argentina.
EM fsaravia@qb.fcen.uba.ar
RI Beauquis, Juan/AAT-5042-2020; Mercogliano, Florencia/HTM-7998-2023;
   Evelson, Pablo/J-1245-2014
OI Pomilio, Carlos Javier/0009-0008-0733-224X; Mercogliano, Maria
   Florencia/0000-0003-1094-9247; Menafra, Martin/0009-0004-8579-6948;
   Saravia, Flavia/0000-0002-0781-0140; Schillaci,
   Roxana/0000-0002-7776-3378; Beauquis, Juan/0000-0003-1404-5632
FU Alberto Roemmers Foundation; Agencia Nacional de Promocion de Ciencia y
   Tecnologia of Argentina (ANPCyT) PICT [2645]; ANPCyT PICT [1012, 1168];
   PIP CONICET [473]; Fundacion Rene Baron
FX This work was supported by a grant to JB from Alberto Roemmers
   Foundation and Agencia Nacional de Promocion de Ciencia y Tecnologia of
   Argentina (ANPCyT) PICT 2013- #2645 and to FS from ANPCyT PICT 2011
   #1012 2014#1168; PIP CONICET 2013-2015 No 473 and Fundacion Rene Baron.
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NR 53
TC 51
Z9 56
U1 0
U2 41
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD OCT
PY 2016
VL 72
BP 22
EP 33
DI 10.1016/j.psyneuen.2016.06.004
PG 12
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA DV0FY
UT WOS:000382594600003
PM 27337091
OA Green Published
DA 2025-06-11
ER

PT J
AU Tsai, TF
   Wang, TS
   Hung, ST
   Tsai, PIC
   Schenkel, B
   Zhang, ML
   Tang, CH
AF Tsai, Tsen-Fang
   Wang, Ting-Shun
   Hung, Sheng-Tzu
   Tsai, Phiona I-Ching
   Schenkel, Brad
   Zhang, Mingliang
   Tang, Chao-Hsiun
TI Epidemiology and comorbidities of psoriasis patients in a national
   database in Taiwan
SO JOURNAL OF DERMATOLOGICAL SCIENCE
LA English
DT Article
DE Epidemiology; Comorbidities; Metabolic syndrome; Psoriasis; National
   Health Insurance; Claims data; Taiwan
ID SYSTEMIC-LUPUS-ERYTHEMATOSUS; HEPATITIS-C; PEMPHIGUS-VULGARIS;
   VIRUS-INFECTION; DISEASE; RISK; PREVALENCE; MORBIDITY; ASSOCIATION;
   COEXISTENCE
AB Background: Recent findings in psoriasis research have shown that psoriasis is frequently associated with systemic comorbidities.
   Objectives: This study aims to describe the epidemiology of psoriasis and the prevalence of comorbidities in patients with psoriasis in Taiwan.
   Methods: Patients who had at least one outpatient visit or admission with ICD-9-CM diagnosis code 696.0-1 in the Taiwan National Health Insurance (NHI) claims database during 2006 were identified as psoriasis cases. The cases were further classified into moderate to severe psoriasis (sPsO) for those who had previously received systemic therapy during the study period and mild psoriasis (mPsO) for those who had not. The cases were matched in a 1:4 ratio with controls from a sample cohort of 997,771 enrolees representative of the Taiwan population. Matching variables included age, gender and residential area. Prevalence of comorbidities was assessed using prevalence relative risk (RR) based upon a Cox proportional regression model.
   Results: 51,800 psoriasis cases were identified (prevalence = 0.235%; mean age = 46.4 +/- 18.6; male:female = 1.6:1) and 17.5% of cases were sPsO type. Psoriasis was associated with a significantly increased prevalence ratio (RR; [95% confidence interval]) for hypertension (1.51; [1.47, 1.56]), diabetes (1.64; [1.58, 1.70]), hyperglyceridaemia (1.61; [1.54, 1.68]), heart disease (1.32; [1.26, 1.37]), hepatitis B viral infection (1.73; [1.47, 2.04]), hepatitis C viral infection (2.02; [1.67, 2.44]), rheumatoid arthritis (3.02; [2.68, 3.41]), systemic lupus erythematosus (6.16; [4.70, 8.09]), vitiligo (5.94; [3.79, 9.31]), pemphigoid (14.75; [5.00, 43.50]), pemphigus (41.81; [12.41, 140.90]), alopecia areata (4.71; [2.98, 7.45]), lip, oral cavity and pharynx cancer (1.49; [1.22, 1.80]), digestive organs and peritoneum cancer (1.57; [1.41, 1.74]), depression (1.50; [1.39, 1.61]), fatty liver (2.27; [1.90, 2.71]), chronic airways obstruction (1.47; [1.34, 1.61]), sleep disorder (3.89; [2.26, 6.71]), asthma (1.29; [1.18, 1.40]), and allergic rhinitis (1.25; [1.18, 1.33]). Conversely, psoriasis was not associated with an increased risk of Crohn's disease.
   Conclusions: Psoriasis was associated with a significantly increased risk of comorbidities, especially for those patients with moderate to severe disease. These health associations should be taken into consideration when evaluating the burdens of psoriasis and designing effective treatment plans. (C) 2011 Japanese Society for Investigative Dermatology. Published by Elsevier Ireland Ltd. All rights reserved.
C1 [Hung, Sheng-Tzu; Tang, Chao-Hsiun] Taipei Med Univ, Sch Hlth Care Adm, Taipei 110, Taiwan.
   [Tsai, Tsen-Fang; Wang, Ting-Shun] Natl Taiwan Univ, Coll Med, Dept Dermatol, Taipei 10764, Taiwan.
   [Tsai, Tsen-Fang; Wang, Ting-Shun] Natl Taiwan Univ Hosp, Taipei, Taiwan.
   [Tsai, Phiona I-Ching] Janssen Cilag Taiwan, Taipei, Taiwan.
   [Schenkel, Brad; Zhang, Mingliang] Johnson & Johnson Pharmaceut Serv LLC, Horsham, PA USA.
   [Tang, Chao-Hsiun] Taipei Med Univ Hosp, Gynecol Res Ctr, Taipei, Taiwan.
C3 Taipei Medical University; National Taiwan University; National Taiwan
   University; National Taiwan University Hospital; Johnson & Johnson;
   Johnson & Johnson Taiwan; Johnson & Johnson; Johnson & Johnson USA;
   Taipei Medical University; Taipei Medical University Hospital
RP Tang, CH (corresponding author), Taipei Med Univ, Sch Hlth Care Adm, 250 Wu Hsing St, Taipei 110, Taiwan.
EM chtang@tmu.edu.tw
RI Chan, Lung/AAI-6349-2020
OI TSAI, TSEN-FANG/0000-0002-1498-1474
FU Janssen-Cilag
FX The financial support provided by Janssen-Cilag is gratefully
   acknowledged; it should, however, be emphasized that the authors have
   retained total independence in the preparation of this manuscript.
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NR 52
TC 254
Z9 266
U1 2
U2 34
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0923-1811
EI 1873-569X
J9 J DERMATOL SCI
JI J. Dermatol. Sci.
PD JUL
PY 2011
VL 63
IS 1
BP 40
EP 46
DI 10.1016/j.jdermsci.2011.03.002
PG 7
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 780IA
UT WOS:000291846500006
PM 21543188
DA 2025-06-11
ER

PT J
AU Gernier, F
   Ahmed-Lecheheb, D
   Pautier, P
   Floquet, A
   Nadeau, C
   Frank, S
   Alexandre, J
   Selle, F
   Berton-Rigaud, D
   Kalbacher, E
   Orfeuvre, H
   Lortholary, A
   Augereau, P
   Labombarda, F
   Perrier, L
   Grellard, JM
   Licaj, I
   Clarisse, B
   Savoye, AM
   Bourien, H
   Rouge, TD
   Kurtz, JE
   Kerdja, K
   Lelaidier, A
   Charreton, A
   Ray-Coquard, I
   Joly, F
AF Gernier, Francois
   Ahmed-Lecheheb, Djihane
   Pautier, Patricia
   Floquet, Anne
   Nadeau, Cedric
   Frank, Sophie
   Alexandre, Jerome
   Selle, Frederic
   Berton-Rigaud, Dominique
   Kalbacher, Elsa
   Orfeuvre, Hubert
   Lortholary, Alain
   Augereau, Paule
   Labombarda, Fabien
   Perrier, Lionel
   Grellard, Jean-Michel
   Licaj, Idlir
   Clarisse, Benedicte
   Savoye, Aude-Marie
   Bourien, Heloise
   Rouge, Thibaut De La Motte
   Kurtz, Jean-Emmanuel
   Kerdja, Katia
   Lelaidier, Anais
   Charreton, Amandine
   Ray-Coquard, Isabelle
   Joly, Florence
TI "Chronic fatigue, quality of life and long-term side-effects of
   chemotherapy in patients treated for non-epithelial ovarian cancer:
   national case-control protocol study of the GINECO-Vivrovaire rare
   tumors INCa French network for rare malignant ovarian tumors"
SO BMC CANCER
LA English
DT Article
DE Germ cell ovarian neoplasms; Sex cord stromal tumors; Long-term effects;
   Survivorship; Chemotherapy; Fatigue; Quality of life; Physical sequelae;
   Cardiovascular and pulmonary disorders
ID CISPLATIN-BASED CHEMOTHERAPY; TESTICULAR CANCER; SURVIVORSHIP RESEARCH;
   METABOLIC SYNDROME; CARDIAC-FUNCTION; PREVALENCE; VALIDATION;
   OTOTOXICITY; DEPRESSION; STRATEGIES
AB Background: Germ cell tumors and sex cord stromal tumors are rare cancers of the ovary. They mainly affect young women and are associated with a high survival rate. The standard treatment mainly involves conservative surgery combined with chemotherapy [bleomycin, etoposide and cisplatin (BEP)] depending on the stage and the prognostic factors, as for testicular cancers. As reported in testicular cancer survivors, chemotherapy may induce sequelae impacting quality of life, which has not yet been evaluated in survivors of germ cell tumors and sex cord stromal tumors. The GINECO-VIVROVAIRE-Rare tumor study is a two-step investigation aiming to assess i) chronic fatigue and quality of life and ii) long-term side-effects of chemotherapy with a focus on cardiovascular and pulmonary disorders.
   Methods: Using self-reported questionnaires, chronic fatigue and quality of life are compared between 134 ovarian cancer survivors (cancer-free >= 2 years after treatment) treated with surgery and chemotherapy and 2 control groups (67 ovarian cancer survivors treated with surgery alone and 67 age-matched healthy women). Medical data are collected from patient records. In the second step evaluating the long-term side-effects of chemotherapy, a subgroup of 90 patients treated with chemotherapy and 45 controls undergo the following work-up: cardiovascular evaluation (clinical examination, non-invasive cardiovascular tests to explore heart disease, blood tests), pulmonary function testing, audiogram, metabolic and hormonal blood tests. Costs of sequelae will be also assessed. Patients are selected from the registry of the INCa French Network for Rare Malignant Ovarian Tumors, and healthy women by the 'Seintinelles' connected network (collaborative research platform).
   Discussion: This study will provide important data on the potential long-term physical side-effects of chemotherapy in survivors of Germ Cell Tumors (GCT) and Sex Cord Stromal Tumors (SCST), especially cardiovascular and pulmonary disorders, and neurotoxicity. The identification of long-term side-effects can contribute to adjusting the treatment of ovarian GCT or SCST patients and to managing follow-up with adapted recommendations regarding practices and chemotherapy regimens, in order to reduce toxicity while maintaining efficacy. Based on the results, intervention strategies could be proposed to improve the management of these patients during their treatment and in the long term.
C1 [Gernier, Francois; Ahmed-Lecheheb, Djihane; Grellard, Jean-Michel; Licaj, Idlir; Clarisse, Benedicte; Kerdja, Katia; Joly, Florence] Baclesse Canc Ctr, Clin Res Dept, 3 Av Gen Harris, F-14076 Caen, France.
   [Gernier, Francois; Ahmed-Lecheheb, Djihane; Licaj, Idlir; Joly, Florence] INSERM, U1086, Caen, France.
   [Pautier, Patricia] Univ Paris Saclay, Gustave Roussy Canc Ctr, Dept Med Oncol, Villejuif, France.
   [Floquet, Anne] Bergonie Canc Ctr, Bordeaux, France.
   [Nadeau, Cedric] Univ Hosp Poitiers, Poitiers, France.
   [Frank, Sophie] Curie Canc Ctr, Paris, France.
   [Alexandre, Jerome] Univ Hosp Cochin Hotel Dieu Broca, Paris, France.
   [Selle, Frederic] Hosp Diaconesses Croix St Simon, Paris, France.
   [Berton-Rigaud, Dominique] Integrated Ctr Oncol Nantes Angers, St Herblain, France.
   [Kalbacher, Elsa] Univ Hosp Jean Minjoz, Besancon, France.
   [Orfeuvre, Hubert] Hosp Fleyriat, Bourg En Bresse, France.
   [Lortholary, Alain] Catherine Sienne Ctr, Nantes, France.
   [Augereau, Paule] Integrated Ctr Oncol Nantes Angers, Angers, France.
   [Labombarda, Fabien] Univ Hosp Caen, Dept Cardiol, Caen, France.
   [Perrier, Lionel] Univ Lyon, Ctr Leon Berard, GATE L SE UMR 5824, Lyon, France.
   [Savoye, Aude-Marie] Jean Godinot Canc Ctr, Reims, France.
   [Bourien, Heloise; Rouge, Thibaut De La Motte] Eugene Marquis Canc Ctr, Rennes, France.
   [Kurtz, Jean-Emmanuel] Univ Hosp Strasbourg, Strasbourg, France.
   [Lelaidier, Anais] Baclesse Canc Ctr, North West Canceropole Data Ctr, Caen, France.
   [Charreton, Amandine; Ray-Coquard, Isabelle] Univ Claude Bernard, Leon Berard Canc Ctr, Lab HESPER, Lyon, France.
   [Joly, Florence] Univ Caen Basse Normandie, UMR S1077, Caen, France.
   [Joly, Florence] CHU Caen, Dept Oncol, Caen, France.
C3 Institut National de la Sante et de la Recherche Medicale (Inserm);
   Universite Paris Saclay; UNICANCER; Gustave Roussy; Universite de
   Poitiers; CHU Poitiers; Universite Paris Cite; Universite de
   Franche-Comte; CHU Besancon; CHU de Caen NORMANDIE; Universite de Caen
   Normandie; Centre National de la Recherche Scientifique (CNRS); CNRS -
   Institute for Humanities & Social Sciences (INSHS); UNICANCER; Centre
   Leon Berard; UNICANCER; Institut Jean Godinot; Universite de Rennes;
   UNICANCER; Centre Eugene Marquis; CHU Strasbourg; Universite Claude
   Bernard Lyon 1; UNICANCER; Centre Leon Berard; Universite de Caen
   Normandie; CHU de Caen NORMANDIE; Universite de Caen Normandie
RP Gernier, F (corresponding author), Baclesse Canc Ctr, Clin Res Dept, 3 Av Gen Harris, F-14076 Caen, France.; Gernier, F (corresponding author), INSERM, U1086, Caen, France.
EM f.gernier@baclesse.unicancer.fr
RI joly, florence/AAF-9191-2020; Labombarda, Fabien/AAE-7747-2020; Gernier,
   François/AAI-3677-2021; GRELLARD, Jean-Michel/GPX-7642-2022; Licaj,
   Idlir/AAC-2772-2021
OI Licaj, PhD, Idlir/0000-0003-3389-0735; CHARRETON,
   Amandine/0009-0000-6369-7413; GERNIER, Francois/0000-0001-9287-0246
FU ARC Foundation for Cancer Research
FX This work is supported by the ARC Foundation for Cancer Research. In the
   context of this major external funding, the study protocol has undergone
   peer-review by the funding body. The funding body played no role in the
   design of the study and collection, analysis, and interpretation of data
   and in writing the manuscript.
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NR 38
TC 6
Z9 7
U1 0
U2 3
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2407
J9 BMC CANCER
JI BMC Cancer
PD OCT 26
PY 2021
VL 21
IS 1
AR 1147
DI 10.1186/s12885-021-08864-8
PG 12
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA WN0CB
UT WOS:000711443600002
PM 34702204
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Ong, P
   Athanasiadis, A
   Borgulya, G
   Mahrholdt, H
   Kaski, JC
   Sechtem, U
AF Ong, Peter
   Athanasiadis, Anastasios
   Borgulya, Gabor
   Mahrholdt, Heiko
   Kaski, Juan Carlos
   Sechtem, Udo
TI High Prevalence of a Pathological Response to Acetylcholine Testing in
   Patients With Stable Angina Pectoris and Unobstructed Coronary Arteries
   The ACOVA Study (Abnormal COronary VAsomotion in patients with stable
   angina and unobstructed coronary arteries)
SO JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
LA English
DT Article
DE acetylcholine; coronary spasm; normal coronary arteries; stable angina
ID CARDIAC SYNDROME-X; ISCHEMIA SYNDROME EVALUATION; OXIDE SYNTHASE GENE;
   CHEST-PAIN; MYOCARDIAL-ISCHEMIA; MICROVASCULAR SPASM; VASOSPASTIC
   ANGINA; SEGMENT DEPRESSION; NATIONAL-HEART; ANGIOGRAPHY
AB Objectives This study aimed at determining the prevalence of epicardial and microvascular coronary spasm in patients with anginal symptoms, despite angiographically normal coronary arteries.
   Background Despite a typical clinical presentation with exercise-related anginal symptoms (chest pain or dyspnea) with or without occasional attacks of resting chest pain suggestive of coronary artery disease, 40% of patients undergoing diagnostic angiography have normal or "near" normal coronary arteriograms. Many of these patients are given a diagnosis of noncardiac chest pain, and some are considered to have microvascular angina. However, we speculate that abnormal coronary vasomotion (reduced vasodilatation with exercise = reduced coronary flow reserve and/or vasospasm at rest) might also represent a plausible explanation for the symptoms of the patient.
   Methods This was a prospective study in 304 consecutive patients (50% men, mean age 66 +/- 10 years) with exertional anginal symptoms undergoing diagnostic angiography. A total of 139 patients (46%) had >= 50% coronary artery disease in at least 1 coronary artery, 21 patients (7%) had luminal narrowings ranging from >20% to 49%, and 144 patients (47%) had normal coronary arteries or only minimal irregularities (<20% diameter reduction).
   Results One hundred twenty-four patients of the latter (86%) underwent intracoronary acetylcholine (ACH) testing, which7 elicited coronary spasm in 77 patients (62%), 35 patients (45%) with epicardial spasm (>= 75% diameter reduction with reproduction of the symptoms of the patient) and 42 patients (55%) with microvascular spasm (reproduction of symptoms, ischemic electrocardiographic changes, and no epicardial spasm).
   Conclusions Nearly 50% of patients undergoing diagnostic angiography for assessment of stable angina had angiographically normal or near normal coronary arteriograms. The ACH test triggered epicardial or microvascular coronary spasm in nearly two-thirds of these patients. Our results suggest that abnormal coronary vasomotion plays a pathogenic role in this setting and that the ACH test might be useful to identify patients with cardiac symptoms, despite normal coronaries. (Abnormal Coronary Vasomotion in Patients With Suspected CAD But Normal Coronary Arteries; NCT00921856) (J Am Coll Cardiol 2012;59:655-62) (C) 2012 by the American College of Cardiology Foundation
C1 [Ong, Peter; Athanasiadis, Anastasios; Mahrholdt, Heiko; Sechtem, Udo] Robert Bosch Krankenhaus, Dept Cardiol, D-70376 Stuttgart, Germany.
   [Borgulya, Gabor] St Georges Univ London, Clin Trials Unit, London, England.
   [Kaski, Juan Carlos] St Georges Univ London, Cardiovasc Sci Res Ctr, London, England.
C3 Bosch; Robert Bosch Krankenhaus; City St Georges, University of London;
   St Georges University London; City St Georges, University of London; St
   Georges University London
RP Ong, P (corresponding author), Robert Bosch Krankenhaus, Dept Cardiol, Auerbach St 110, D-70376 Stuttgart, Germany.
EM Peter.Ong@rbk.de
RI Sechtem, Udo/ADK-6380-2022; Kaski, Juan Carlos/LKM-8031-2024
OI Borgulya, Gabor/0000-0001-6396-6126
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NR 34
TC 300
Z9 314
U1 1
U2 12
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0735-1097
J9 J AM COLL CARDIOL
JI J. Am. Coll. Cardiol.
PD FEB 14
PY 2012
VL 59
IS 7
BP 655
EP 662
DI 10.1016/j.jacc.2011.11.015
PG 8
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 893YN
UT WOS:000300393900005
PM 22322081
OA Bronze
DA 2025-06-11
ER

PT J
AU Natae, SF
   Kósa, Z
   Sándor, J
   Merzah, MA
   Bereczky, Z
   Pikó, P
   Adány, R
   Fiatal, S
AF Natae, Shewaye Fituma
   Kosa, Zsigmond
   Sandor, Janos
   Merzah, Mohammed Abdulridha
   Bereczky, Zsuzsanna
   Piko, Peter
   Adany, Roza
   Fiatal, Szilvia
TI The Higher Prevalence of Venous Thromboembolism in the Hungarian Roma
   Population Could Be Due to Elevated Genetic Risk and Stronger
   Gene-Environmental Interactions
SO FRONTIERS IN CARDIOVASCULAR MEDICINE
LA English
DT Article
DE VTE; GxE interactions; ATBp3 mutation; SERPINC1; Roma population;
   general Hungarian
ID METABOLIC SYNDROME; THROMBOSIS; SMOKING; EPIDEMIOLOGY; ASSOCIATION;
   THROMBOPHILIA; SETTLEMENTS; MECHANISMS; DEPRESSION; MUTATIONS
AB Background: Interactions between genetic and environmental risk factors (GxE) contribute to an increased risk of venous thromboembolism (VTE). Understanding how these factors interact provides insight for the early identification of at-risk groups within a population and creates an opportunity to apply appropriate preventive and curative measures.Objective: To estimate and compare GxE for VTE risk in the general Hungarian and Roma populations.Methods: The study was based on data extracted from a database consisting of results previously obtained from a complex health survey with three pillars (questionnaire-based, physical, and laboratory examinations) involving 406 general Hungarian and 395 Roma subjects. DNA was genotyped for rs121909567 (SERPINC1), rs1799963 (F2), rs2036914 (F11), rs2066865 (FGG), rs6025 (F5), and rs8176719 (ABO) polymorphisms. After allele frequency comparisons, the odds ratio (OR) was calculated for individual SNPs. Furthermore, genetic risk scores (weighted GRS, unweighted GRS) were computed to estimate the joint effect of the genetic factors. Multivariable linear regression analysis was applied to test the impact of GxE on VTE risk after interaction terms were created between genetic and VTE risk factors [diabetes mellitus (DM), cancer, chronic kidney diseases (CKD), coronary artery diseases (CAD), migraine, depression, obesity, total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high density lipoprotein (HDL-C), triglyceride (TG), and smoking].Results: Interestingly, the rs121909567 (SERPINC1, ATBp3 mutation) SNP was not present in the general population at all. However, the risk allele frequency was 1% among the Roma population, which might suggest a founder effect in this minority. This polymorphism multiplicatively interacted with CAD, CKD, cancer, DM, depression, migraine, and obesity. Even though interactions were not statistically significant, the trend of interaction showed the probability of an incremental VTE risk among the Roma population. The risk of VTE was 4.7 times higher (p > 0.05) for Roma subjects who had >= 3 wGRS (median value) compared with individuals having lower wGRS values but lower for the general subjects (OR = 3.1 x 10(-8)). Additionally, the risk of VTE was 6.6 times higher in the Roma population that had >= 3 risk alleles (median value) than in individuals with the 0-1 risk allele, and the overall risk was much higher for the Roma population (OR = 6.6; p > 0.05) than for the general Hungarian population (OR = 1.5; p > 0.05). Five positive and significant GxE interactions were identified in the Roma population. The risk of VTE was higher among depressive Roma subjects who carried the risk variant rs2036914 (beta = 0.819, p = 0.02); however, this interaction was not significant for the general subjects. The joint presence of high levels of LDL-C and rs2066865 (FGG) increased the VTE risk only among Roma individuals (beta = 0.389, p = 0.002). The possibility of VTE risk increment, as a result of a multiplicative interaction between rs8176719 (ABO) and cancer, was identified, which was higher for the Roma population (beta = 0.370, p < 0.001) than for the general population (beta = -0.042, p = 0.6). The VTE risk increased in the Roma population (beta = 0.280, p = 0.001), but was higher in the general population (beta = 0.423, p = 0.001) as a result of the multiplicative interaction between CAD and rs2036914 (F11).
   The presence of a multiplicative interaction between rs2066865 (FGG) and CAD increased the VTE risk for the Roma population (beta = 0.143, p = 0.046) but not for the general population (beta = -0.329, p < 0.001).Conclusions: rs121909567 (SERPINC1, ATBp3) was confirmed as a founder mutation in the Roma population. Our study revealed some evidence on the burden of the joint presence of genetic and environmental risk factors on VTE, although the finding is highly subjected to the selection and observational biases due to the very small number of VTE cases and the observational nature of the study design, respectively. As a result of higher genetic load and GxE interactions, this minority Roma population is at higher risk of VTE than the general Hungarian population. Thus, our results suggest the need for an intensive search for the rs121909567 (SERPINC1; ATBp3) founder mutation, which might be an important factor for the assessment of thrombotic disease susceptibility among the Roma population. In addition, we strongly recommend further studies among a large number of VTE cases to explore the more precise impact of genetic and environmental risk factors on VTE in the study populations.
C1 [Natae, Shewaye Fituma; Sandor, Janos; Merzah, Mohammed Abdulridha; Adany, Roza; Fiatal, Szilvia] Univ Debrecen, Fac Med, Dept Publ Hlth & Epidemiol, Debrecen, Hungary.
   [Natae, Shewaye Fituma; Merzah, Mohammed Abdulridha; Adany, Roza] Univ Debrecen, Doctoral Sch Hlth Sci, Debrecen, Hungary.
   [Kosa, Zsigmond] Univ Debrecen, Fac Hlth, Dept Hlth Methodol & Publ Hlth, Nyiregyhaza, Hungary.
   [Bereczky, Zsuzsanna] Univ Debrecen, Fac Med, Dept Lab Med, Div Clin Lab Sci, Debrecen, Hungary.
   [Piko, Peter; Adany, Roza] Univ Debrecen, Magyar Tud Akad Debreceni Egyet MTA Publ Hlth Res, Debrecen, Hungary.
C3 University of Debrecen; University of Debrecen; University of Debrecen;
   University of Debrecen; University of Debrecen
RP Fiatal, S (corresponding author), Univ Debrecen, Fac Med, Dept Publ Hlth & Epidemiol, Debrecen, Hungary.
EM fiatal.szilvia@med.unideb.hu
RI Merzah, Mohammed/AAL-9462-2020; Dr Fiatal, Szilvia/GQH-2653-2022; Piko,
   Peter/AAG-5784-2021
OI Merzah, Mohammed/0000-0003-4019-6290; Piko, Peter/0000-0001-5539-907X
FU Stipendium Hungaricum Scholarship Programme of the Tempus Public
   Foundation; European Union under the European Regional Development Fund
   [GINOP-2.3.2-15-2016-00005, GINOP-2.3.2-15-2016-00039]; Hungarian
   Academy of Sciences [MTA11010, TK2016-78]; National Research,
   Development and Innovation Office, Hungarian Ministry of Innovation and
   Technology [OTKA K116228]; National Research, Development and Innovation
   Fund of Hungary under the K_20 funding scheme [135784];  [K116228]; 
   [K_20]
FX This study was financed by the Stipendium Hungaricum Scholarship
   Programme of the Tempus Public Foundation, the European Union under the
   European Regional Development Fund (GINOP-2.3.2-15-2016-00005 and
   GINOP-2.3.2-15-2016-00039), the Hungarian Academy of Sciences (MTA11010
   and TK2016-78) and the National Research, Development and Innovation
   Office, Hungarian Ministry of Innovation and Technology (Grant No. OTKA
   K116228). Project no. 135784 has also been implemented with the support
   provided by the National Research, Development and Innovation Fund of
   Hungary, financed under the K_20 funding scheme.
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NR 76
TC 4
Z9 4
U1 0
U2 5
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2297-055X
J9 FRONT CARDIOVASC MED
JI Front. Cardiovasc. Med.
PD OCT 26
PY 2021
VL 8
AR 647416
DI 10.3389/fcvm.2021.647416
PG 13
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA XI6EL
UT WOS:000726202200001
PM 34765649
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Ryu, SK
   King, TJ
   Fujioka, K
   Pattison, J
   Pashkow, FJ
   Tsimikas, S
AF Ryu, Sung Kee
   King, Timothy J.
   Fujioka, Kazutoshi
   Pattison, Jennifer
   Pashkow, Fredrick J.
   Tsimikas, Sotirios
TI Effect of an oral astaxanthin prodrug (CDX-085) on lipoprotein levels
   and progression of atherosclerosis in LDLR<SUP>-/-</SUP> and
   ApoE<SUP>-/-</SUP> mice
SO ATHEROSCLEROSIS
LA English
DT Article
DE Antioxidants; Lipoproteins; Atherosclerosis; Carotenoids; Inflammation
ID LOW-DENSITY-LIPOPROTEIN; CARDIOVASCULAR-DISEASE; OXIDATIVE STRESS;
   IN-VIVO; METABOLIC SYNDROME; ALPHA-TOCOPHEROL; PART I; ANTIOXIDANT;
   CHOLESTEROL; ADIPONECTIN
AB Oxidative stress and inflammation are key promoters of atherosclerosis and myocardial damage. When orally administered, the novel astaxanthin prodrug CDX-085 delivers high levels of the xanthophyll antioxidant astaxanthin that protects LDL from oxidation and reduces primary thrombosis. In this study, we analyzed whether delivery of astaxanthin from administration of the CDX-085 prodrug reduces plasma lipoprotein levels and the progression of atherosclerosis in low-density lipoprotein receptor negative (LDLR-/-) and apolipoprotein E deficient (ApoE(-/-)) mice.
   Methods: Relative circulating levels of astaxanthin derived from CDX-085 administration compared to administration of pure astaxanthin was initially evaluated in a canine model. In mouse Study #1, 16 wild-type and 16 LDLR-/- mice on 0.5% cholesterol diet supplemented with either 0.0%, 0.08%, 0.2% and 0.4% CDX-085 were used to assess plasma levels and lipoprotein biodistribution measured by FPLC after 4 weeks treatment. In Study #2, 36 male LDLR-/- mice were randomized to a 0.5% cholesterol chow diet (CHOW group, n = 12) or 0.5% cholesterol chow fortified with 0.08% CDX-085 (n = 12) or 0.5% cholesterol chow with 0.4% CDX-085 (n = 12) for 12 weeks. In Study #3, 34 male ApoE(-/-) mice were randomized in the same fashion as the Study #2 and fed similar diets for 9 weeks.
   Results: CDX-085 administration was shown to result in significantly higher levels of circulating astaxanthin (p < 0.001 ANOVA) over a 72 h period compared to pure, non-esterified astaxanthin in a single-dose pharmacokinetic study in beagles. In Study #1, plasma astaxanthin levels were 5-9-fold higher in LDLR-/- mice compared to wild-type mice. Astaxanthin was highly distributed among all lipoprotein fractions, generally reflecting cholesterol content of lipoproteins. In Study #2, administration of CDX-085 resulted in significantly lower total cholesterol levels (528 +/- 68 mg/dL vs. 550 +/- 67 mg/dL vs. 602 +/- 80 mg/dL, p = 0.047) and aortic arch atherosclerosis (9.0 +/- 4.2% vs. 9.8 +/- 3.5% vs. 13.2 +/- 3.6%, p = 0.023) in the 0.4% CDX-085 group compared to the 0.08% CDX-085 and CHOW groups, respectively. In ApoE(-/-) mice, a 72% reduction in triglycerides in the 0.4% CDX-085 group and 50% reduction in the 0.08% CDX-085 groups was noted compared to CHOW group (final levels 17 +/- 11 mg/dL vs. 30 +/- 15 mg/dL vs. 60 +/- 32 mg/dL, respectively, p = 0.001).
   Conclusion: Oral administration of the novel astaxanthin prodrug CDX-085 shows that it distributes among lipoproteins. CDX-085 lowers total cholesterol and aortic arch atherosclerosis in LDLR-/-mice and triglyceride levels in ApoE(-/-) mice and shows promise for further evaluation in human studies. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
C1 [Tsimikas, Sotirios] Univ Calif San Diego, Vasc Med Program, Div Cardiovasc Dis, La Jolla, CA 92093 USA.
   [Ryu, Sung Kee] Eulji Univ, Sch Med, Eulji Gen Hosp, Div Cardiol, Seoul, South Korea.
   [King, Timothy J.; Fujioka, Kazutoshi; Pashkow, Fredrick J.] Cardax Pharmaceut, Honolulu, HI USA.
C3 University of California System; University of California San Diego;
   Eulji University
RP Tsimikas, S (corresponding author), Univ Calif San Diego, Vasc Med Program, Div Cardiovasc Dis, 9500 Gilman Dr, La Jolla, CA 92093 USA.
EM stsimikas@ucssd.edu
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NR 36
TC 38
Z9 40
U1 2
U2 52
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0021-9150
EI 1879-1484
J9 ATHEROSCLEROSIS
JI Atherosclerosis
PD MAY
PY 2012
VL 222
IS 1
BP 99
EP 105
DI 10.1016/j.atherosclerosis.2012.02.002
PG 7
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 928DJ
UT WOS:000302960600015
PM 22406426
DA 2025-06-11
ER

PT J
AU Korkmaz-Icöz, S
   Al Said, S
   Radovits, T
   Li, SL
   Brune, M
   Hegedus, P
   Atmanli, A
   Ruppert, M
   Brlecic, P
   Lehmann, LH
   Lahrmann, B
   Grabe, N
   Yoshikawa, Y
   Yasui, H
   Most, P
   Karck, M
   Szabó, G
AF Korkmaz-Icoz, Sevil
   Al Said, Samer
   Radovits, Tamas
   Li, Shiliang
   Brune, Maik
   Hegedus, Peter
   Atmanli, Ayhan
   Ruppert, Mihaly
   Brlecic, Paige
   Lehmann, Lorenz Heyne
   Lahrmann, Bernd
   Grabe, Niels
   Yoshikawa, Yutaka
   Yasui, Hiroyuki
   Most, Patrick
   Karck, Matthias
   Szabo, Gabor
TI Oral treatment with a zinc complex of acetylsalicylic acid prevents
   diabetic cardiomyopathy in a rat model of type-2 diabetes: activation of
   the Akt pathway
SO CARDIOVASCULAR DIABETOLOGY
LA English
DT Article
DE Cardiac function; Diabetic cardiomyopathy; Type-2 diabetes mellitus;
   Zinc-aspirin complex
ID ISCHEMIA-REPERFUSION INJURY; GENE-EXPRESSION PATTERN; METABOLIC
   SYNDROME; ANGIOTENSIN-II; CONTRACTILE FUNCTION; PATHOLOGICAL-CHANGES;
   CARDIAC-HYPERTROPHY; INSULIN-RESISTANCE; HEART; ASPARTATE
AB Background: Type-2 diabetics have an increased risk of cardiomyopathy, and heart failure is a major cause of death among these patients. Growing evidence indicates that proinflammatory cytokines may induce the development of insulin resistance, and that anti-inflammatory medications may reverse this process. We investigated the effects of the oral administration of zinc and acetylsalicylic acid, in the form of bis(aspirinato)zinc(II)-complex Zn(ASA)(2), on different aspects of cardiac damage in Zucker diabetic fatty (ZDF) rats, an experimental model of type-2 diabetic cardiomyopathy.
   Methods: Nondiabetic control (ZL) and ZDF rats were treated orally with vehicle or Zn(ASA)(2) for 24 days. At the age of 29-30 weeks, the electrical activities, left-ventricular functional parameters and left-ventricular wall thicknesses were assessed. Nitrotyrosine immunohistochemistry, TUNEL-assay, and hematoxylin-eosin staining were performed. The protein expression of the insulin-receptor and PI3K/AKT pathway were quantified by Western blot.
   Results: Zn(ASA)(2)-treatment significantly decreased plasma glucose concentration in ZDF rats (39.0 +/- 3.6 vs 49.4 +/- 2.8 mM, P < 0.05) while serum insulin-levels were similar among the groups. Data from cardiac catheterization showed that Zn(ASA)(2) normalized the increased left-ventricular diastolic stiffness (end-diastolic pressure-volume relationship: 0.064 +/- 0.008 vs 0.084 +/- 0.014 mmHg/mu l; end-diastolic pressure: 6.5 +/- 0.6 vs 7.9 +/- 0.7 mmHg, P < 0.05). Furthermore, ECG-recordings revealed a restoration of prolonged QT-intervals (63 +/- 3 vs 83 +/- 4 ms, P < 0.05) with Zn(ASA)(2). Left-ventricular wall thickness, assessed by echocardiography, did not differ among the groups. However histological examination revealed an increase in the cardiomyocytes' transverse cross-section area in ZDF compared to the ZL rats, which was significantly decreased after Zn(ASA)(2)-treatment. Additionally, a significant fibrotic remodeling was observed in the diabetic rats compared to ZL rats, and Zn(ASA)(2)-administered ZDF rats showed a similar collagen content as ZL animals. In diabetic hearts Zn(ASA)(2) significantly decreased DNA-fragmentation, and nitro-oxidative stress, and up-regulated myocardial phosphorylated-AKT/AKT protein expression. Zn(ASA)(2) reduced cardio-myocyte death in a cellular model of oxidative stress. Zn(ASA)(2) had no effects on altered myocardial CD36, GLUT-4, and PI3K protein expression.
   Conclusions: We demonstrated that treatment of type-2 diabetic rats with Zn(ASA)(2) reduced plasma glucose-levels and prevented diabetic cardiomyopathy. The increased myocardial AKT activation could, in part, help to explain the cardioprotective effects of Zn(ASA)(2). The oral administration of Zn(ASA)(2) may have therapeutic potential, aiming to prevent/treat cardiac complications in type-2 diabetic patients.
C1 [Korkmaz-Icoz, Sevil; Al Said, Samer; Li, Shiliang; Hegedus, Peter; Atmanli, Ayhan; Ruppert, Mihaly; Brlecic, Paige; Karck, Matthias; Szabo, Gabor] Univ Heidelberg Hosp, Dept Cardiac Surg, Lab Cardiac Surg, Neuenheimer Feld 326, D-69120 Heidelberg, Germany.
   [Radovits, Tamas; Ruppert, Mihaly] Semmelweis Univ, Heart & Vasc Ctr, Varosmajor U 68, H-1122 Budapest, Hungary.
   [Brune, Maik] Univ Heidelberg Hosp, Dept Internal Med & Clin Chem, Neuenheimer Feld 671, D-69120 Heidelberg, Germany.
   [Lehmann, Lorenz Heyne] Univ Heidelberg Hosp, Dept Cardiol Angiol & Pulmonol, Neuenheimer Feld 410, D-69120 Heidelberg, Germany.
   [Lahrmann, Bernd; Grabe, Niels] Heidelberg Univ, Bioquant, Hamamatsu Tissue Imaging & Anal Ctr TIGA, D-69120 Heidelberg, Germany.
   [Lahrmann, Bernd; Grabe, Niels] Steinbeis Transfer Ctr Med Syst Biol, D-69124 Heidelberg, Germany.
   [Grabe, Niels] Heidelberg Univ, Natl Ctr Tumor Dis, Dept Med Oncol, D-69120 Heidelberg, Germany.
   [Yoshikawa, Yutaka; Yasui, Hiroyuki] Kyoto Pharmaceut Univ, Dept Analyt & Bioinorgan Chem, Kyoto 6078414, Japan.
   [Most, Patrick] Univ Heidelberg Hosp, Dept Internal Med 3, Mol & Translat Cardiol, Neuenheimer Feld 410, D-69120 Heidelberg, Germany.
C3 Ruprecht Karls University Heidelberg; Semmelweis University; Ruprecht
   Karls University Heidelberg; Ruprecht Karls University Heidelberg;
   Ruprecht Karls University Heidelberg; Helmholtz Association; German
   Cancer Research Center (DKFZ); Ruprecht Karls University Heidelberg;
   National Center for Tumor Diseases; Kyoto Pharmaceutical University;
   Ruprecht Karls University Heidelberg
RP Korkmaz-Icöz, S (corresponding author), Univ Heidelberg Hosp, Dept Cardiac Surg, Lab Cardiac Surg, Neuenheimer Feld 326, D-69120 Heidelberg, Germany.
EM korkmaz@uni-heidelberg.de
RI Hegedus, Peter/ABA-8580-2021; Grabe, Niels/AAP-6493-2020; Yasui,
   Hiroyuki/AAW-7976-2020; Lehmann, Lorenz/IQS-8243-2023; li,
   shiliang/K-9864-2018
OI Al Said, Samer/0000-0002-3262-3785; Lehmann, Lorenz/0000-0001-5077-8580;
   Szabo, Gabor/0000-0001-6038-9968; Hegedus, Peter/0000-0003-1452-1571;
   Grabe, Niels/0000-0003-1732-3706; Yasui, Hiroyuki/0000-0003-3317-3947;
   Atmanli, Ayhan/0000-0001-6951-8893; Yoshikawa,
   Yutaka/0000-0002-7177-1975
FU Deutsche Stiftung fur Herzforschung (German Heart Research Foundation);
   Medical Faculty of the University of Heidelberg; Hungarian Scientific
   Research Fund [OTKA PD100245]; Janos Bolyai Research Scholarship of the
   Hungarian Academy of Sciences
FX This study was supported by the Deutsche Stiftung fur Herzforschung
   (German Heart Research Foundation) (to S. Korkmaz-Icoz and T. Radovits),
   by the Medical Faculty of the University of Heidelberg (to S.
   Korkmaz-Icoz), by the Hungarian Scientific Research Fund (OTKA PD100245
   to T. Radovits), and by the Janos Bolyai Research Scholarship of the
   Hungarian Academy of Sciences (to T. Radovits). The excellent technical
   assistance of Patricia Kraft, Tobias Mayer, Karin Sonnenberg, Ulrike
   Vogt, and Lutz Hoffmann is greatly acknowledged.
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NR 55
TC 31
Z9 33
U1 0
U2 21
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1475-2840
J9 CARDIOVASC DIABETOL
JI Cardiovasc. Diabetol.
PD MAY 6
PY 2016
VL 15
AR 75
DI 10.1186/s12933-016-0383-8
PG 16
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism
GA DL8SF
UT WOS:000375911000001
PM 27153943
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Wallimann, T
   Riek, U
   Möddel, M
AF Wallimann, Theo
   Riek, Uwe
   Moddel, Michael
TI Intradialytic creatine supplementation: A scientific rationale for
   improving the health and quality of life of dialysis patients
SO MEDICAL HYPOTHESES
LA English
DT Article
DE CKD patients; Dialysis patients; Hemodialysis and peritoneal dialysis
   with creatine; Intra-dialytic or oral creatine supplementation; Kidney
   insufficiency; Kidney failure; Chronic dialysis treatment; Muscle loss;
   Muscle fatigue; Sarcopenia; Mental fatigue; Depressions; Kidney
   transplant; Cardiovascular complications; Atherosclerosis; Inflammation;
   Hyper-homo-cysteinemia; Protection by creatine of erythrocytes and
   immune cells; Protection from oxidative damage and mechanical stress by
   creatine; Sparing of erythropoietin (EPO); Diabetes mellitus type-2;
   Insulin sensitivity; Metabolic syndrome; Dyslipidemia; Fatty liver
   disease; NASH; NAFL; X-ray contrast media induced kidney failure
ID MITOCHONDRIAL PERMEABILITY TRANSITION; MAJOR DEPRESSIVE DISORDER; RIBOSE
   PREVENTS APOPTOSIS; PLACEBO-CONTROLLED TRIAL; II DIABETIC-PATIENTS;
   RED-BLOOD-CELLS; DOUBLE-BLIND; COGNITIVE PERFORMANCE; KINASE ISOENZYMES;
   OXIDATIVE STRESS
AB The CK/PCr-system, with creatine (Cr) as an energy precursor, plays a crucial role in cellular physiology. In the kidney, as in other organs and cells with high and fluctuating energy requirements, energy-charged phospho-creatine (PCr) acts as an immediate high-energy source and energy buffer, and as an intracellular energy transport vehicle. A maximally filled total Cr (Cr plus PCr) pool is a prerequisite for optimal functioning of the body and its organs, and health. Skeletal- and cardiac muscles of dialysis patients with chronic kidney disease (CKD) are depleted of Cr in parallel with the duration of dialysis. The accompanying accumulation of cellular damage seen in CKD patients lead to a deterioration of musculo-skeletal and neurological functioning and poor quality of life (QOL). Therefore, to counteract Cr depletion, it is proposed to supplement CKD patients with Cr. The anticipated benefits include previously documented improvements in the musculo-skeletal system, brain and peripheral nervous system, as well as improvements in the common comorbidities of CKD patients (see below). Thus, with a relatively simple, safe and inexpensive Cr supplementation marked improvements in quality of life (QOL) and life span are likely reached. To avoid Cr and fluid overload by oral Cr administration, we propose intradialytic Cr supplementation, whereby a relatively small amount of Cr is added to the large volume of dialysis solution to a final concentration of 1-10mM. From there, Cr enters the patient's circulation by back diffusion during dialysis. Because of the high affinity of the Cr transporter (CRT) for Cr affinity for Cr (Vmax of CRT for Cr=20-40 mu M Cr), Cr is actively transported from the blood stream into the target cells and organs, including skeletal and cardiac muscle, brain, proximal tubules of kidney epithelial cells, neurons, and leukocytes and erythrocytes, which all express CRT and depend on the CK/PCr system. By this intradialytic strategy, only as much Cr is taken up by the body as is needed to fill the tissue Cr pools and no excess Cr has to be excreted, as is the case with oral Cr. Because aqueous solutions of Cr are not very stable, Cr must be added immediately before dialysis either as solid Cr powder or from a frozen Cr stock solution to the dialysate, or alternatively, Cr could become an additional component of a novel dry dialysate mixture in a cartridge device. (C) 2016 The Authors. Published by Elsevier Ltd.
C1 [Wallimann, Theo; Riek, Uwe] ETH, Dept Biol, Zurich, Switzerland.
   [Moddel, Michael] Nephrol Klin Pk, Zurich, Switzerland.
C3 Swiss Federal Institutes of Technology Domain; ETH Zurich
RP Wallimann, T (corresponding author), Schurmattstr 23, CH-8962 Bergdietikon, AG, Switzerland.
EM theo.wallimann@cell.biol.ethz.ch
RI Wallimann, Theo/C-6047-2008
OI Wallimann, Theo/0000-0003-4957-5836
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NR 163
TC 24
Z9 26
U1 2
U2 19
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0306-9877
EI 1532-2777
J9 MED HYPOTHESES
JI Med. Hypotheses
PD FEB
PY 2017
VL 99
BP 1
EP 14
DI 10.1016/j.mehy.2016.12.002
PG 14
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA EK1XT
UT WOS:000393721800001
PM 28110688
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Yaymaci, B
   Dagdelen, S
   Bozbuga, N
   Demirkol, O
   Say, B
   Guzelmeric, F
   Dindar, I
AF Yaymaci, B
   Dagdelen, S
   Bozbuga, N
   Demirkol, O
   Say, B
   Guzelmeric, F
   Dindar, I
TI The response of the myocardial metabolism to atrial pacing in patients
   with coronary slow flow
SO INTERNATIONAL JOURNAL OF CARDIOLOGY
LA English
DT Article
DE coronary slow flow; myocardial ischemia; atrial pacing; myocardial
   metabolism
ID ANGINA-PECTORIS; SYNDROME-X; ARTERY DISEASE; CHEST PAIN; ARTERIOGRAMS;
   ISCHEMIA
AB The pathophysiology of angina pectoris is not precisely known yet in patients who have no coronary lesion bur slow coronary how by angiography. In this study we aim to display metabolic ischemia via atrial pacing to determine the difference of lactate production and arterio-venous O-2 content difference (AVO(2)). Thirty-four patients with slow coronary flow detected by coronary angiography via the TIMI 'frame count' method were included in this study. The resting and stress images from the patients undergoing myocardial perfusion tomography were recorded, pre and postpacing lactate extraction and AVO(2) content difference values were calculated. Patients were classified according to their metabolic responses to atrial pacing stress. Group I consisted of 28 patients (18 male. 10 female, mean age 54.42 +/-9.61) who did not demonstrate metabolic ischemia and group IT consisted of six patients (four male, two female. mean age 60 +/-5.76) who had metabolic ischemia after the procedure. There was no statistically significant difference between prepacing AVO(2) content difference in group I (57.38 +/-2.05%) and group II (58.23 +/-2.11%) (P=NS). However postpacing AVO(2) content difference of group I and group II was statistically significant (respectively. 57.96 +/-2.65 vs. 68.35 +/-2.15%, P <0.001). In other words, postpacing AVO(2) content difference was unchanged from the basal AVO, content difference level in group I (respectively, 57.38 +/-2.05 vs. 57.96 +/-2.65%; P=NS) in contrast to the postpacing AVO, content difference which increased significantly in group II (58.23 +/-2.11 vs. 68.35 +/-2.15%; P <0.028). Although basal lactate extraction rates were similar in groups I and II (respectively, 0.24 +/-0.1 vs. 0.23 +/-0.18; P=NS), postpacing lactate extraction rates were decreased significantly in the two groups, prominently in group II (0.154 +/-0.15 vs. -0.471 +/-0.27; P <0.0001) which indicated that lactate extraction converted to lactate production. Metabolic ischemia was detected in only 17.6% of patients included in this study and 83.4% of these six patients with proven metabolic ischemia had perfusion defects in scintigraphy. Our data confirmed that angina pectoris was not originated from myocardial ischemia in most of the patients with slow coronary flow. We conclude that perfusion scintigraphy is a reliable and accurate method for detection of true ischemia in this group of patients. (C) 2001 Published by Elsevier Science Ireland Ltd.
C1 Kosuyolu Heart & Res Hosp, Istanbul, Turkey.
C3 Istanbul Kartal Kosuyolu Yuksek Ihtisas Training & Research Hospital
RP Yaymaci, B (corresponding author), Karlidere Caddesi Cumhuriyet Sitesi,B-4 Blok D16, TR-81190 Istanbul, Turkey.
RI Dagdelen, Sinan/B-5869-2018
OI Demirkol, Mehmet Onur/0000-0003-3928-5026
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NR 22
TC 17
Z9 20
U1 0
U2 1
PU ELSEVIER SCI IRELAND LTD
PI CLARE
PA CUSTOMER RELATIONS MANAGER, BAY 15, SHANNON INDUSTRIAL ESTATE CO, CLARE,
   IRELAND
SN 0167-5273
J9 INT J CARDIOL
JI Int. J. Cardiol.
PD APR
PY 2001
VL 78
IS 2
BP 151
EP 156
DI 10.1016/S0167-5273(01)00366-7
PG 6
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 434LA
UT WOS:000168815100007
PM 11334659
DA 2025-06-11
ER

PT J
AU Sjöland, O
   Svensson, T
   Madhawa, K
   Hoang, NT
   Chung, UI
   Svensson, AK
AF Sjoland, Olivia
   Svensson, Thomas
   Madhawa, Kaushalya
   Hoang, N. T.
   Chung, Ung-Il
   Svensson, Akiko Kishi
TI Associations of Subjective Sleep Quality with Wearable Device-Derived
   Resting Heart Rate During REM Sleep and Non-REM Sleep in a Cohort of
   Japanese Office Workers
SO NATURE AND SCIENCE OF SLEEP
LA English
DT Article
DE sleep quality; heart rate; sleep stages; REMS; NREMS; wearable device
ID RATE-VARIABILITY; RISK-FACTOR; MEN; CONSEQUENCES; HYPERTENSION;
   POPULATION; COMPLAINTS; DURATION; INSOMNIA; STRESS
AB Background: Associations between subjective sleep quality and stage-specific heart rate (HR) may have important clinical relevance when aiming to optimize sleep and overall health. The majority of previously studies have been performed during short periods under laboratory-based conditions. The aim of this study was to investigate the associations of subjective sleep quality with heart rate during REM sleep (HR REMS) and non-REM sleep (HR NREMS) using a wearable device (Fitbit Versa). Methods: This is a secondary analysis of data from the intervention group of a randomized controlled trial (RCT) performed between December 3, 2018, and March 2, 2019, in Tokyo, Japan. The intervention group consisted of 179 Japanese office workers with metabolic syndrome (MetS), Pre-MetS or a high risk of developing MetS. HR was collected with a wearable device and sleep quality was assessed with a mobile application where participants answered The St. Mary's Hospital Sleep Questionnaire. Both HR and sleep quality was collected daily for a period of 90 days. Associations of between-individual and within-individual sleep quality with HR REMS and HR NREMS were analyzed with multi-level model regression in 3 multivariate models. Results: The cohort consisted of 92.6% men (n=151) with a mean age (+/- standard deviation) of 44.1 (+/- 7.5) years. A non-significant inverse between-individual association was observed for sleep quality with HR REMS (HR REMS -0.18; 95% CI -0.61, 0.24) and HR NREMS (HR NREMS -0.23; 95% CI -0.66, 0.21), in the final multivariable adjusted models; a statistically significant inverse within-individual association was observed for sleep quality with HR REMS (HR REMS -0.21 95% CI -0.27, -0.15) and HR NREMS (HR NREMS -0.21 95% CI -0.27, -0.14) after final adjustments for covariates. Conclusion: The present study shows a statistically significant within-individual association of subjective sleep quality with HR REMS and HR NREMS. These findings emphasize the importance of considering sleep quality on the individual level. The results may contribute to early detection and prevention of diseases associated with sleep quality which may have important implications on public health given the high prevalence of sleep disturbances in the population.
C1 [Sjoland, Olivia; Svensson, Thomas; Madhawa, Kaushalya; Hoang, N. T.; Chung, Ung-Il; Svensson, Akiko Kishi] Univ Tokyo, Grad Sch Engn, Dept Bioengn, Precis Hlth, 7-3-1 Hongo,Bunkyo Ku, Tokyo 1138656, Japan.
   [Sjoland, Olivia; Svensson, Akiko Kishi] Lund Univ, Skane Univ Hosp, Dept Clin Sci, Malmo, Sweden.
   [Svensson, Thomas; Chung, Ung-Il] Kanagawa Univ Human Serv, Grad Sch Hlth Innovat, Kawasaki Ku, Kawasaki, Kanagawa, Japan.
   [Chung, Ung-Il] Ctr Dis Biol & Integrat Med, Grad Sch Med, Clin Biotechnol, Tokyo, Japan.
   [Svensson, Akiko Kishi] Univ Tokyo, Dept Diabet & Metab Dis, Tokyo, Japan.
C3 University of Tokyo; Lund University; Skane University Hospital;
   University of Tokyo
RP Svensson, T (corresponding author), Univ Tokyo, Grad Sch Engn, Dept Bioengn, Precis Hlth, 7-3-1 Hongo,Bunkyo Ku, Tokyo 1138656, Japan.
EM thomas.svensson@med.lu.se
RI Svensson, Thomas/AAJ-4578-2020
FU Center of Innovation Program of the Japan Science and Technology Agency,
   JST [JPMJCE1304]; Kanagawa prefecture's "A project to expand the use of
   metabolic syndrome risk index in municipalities" (2018)
FX This research was supported by the Center of Innovation Program of the
   Japan Science and Technology Agency, JST (Grant Number JPMJCE1304) , and
   Kanagawa prefecture's "A project to expand the use of metabolic syndrome
   risk index in municipalities" (2018) .
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NR 41
TC 2
Z9 2
U1 3
U2 6
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1179-1608
J9 NAT SCI SLEEP
JI NAT. SCI. SLEEP
PY 2024
VL 16
BP 867
EP 877
DI 10.2147/NSS.S455784
PG 11
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA WK6V5
UT WOS:001254811400001
PM 38947940
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Patil, SG
   Khode, V
   Christa, E
   Desai, RM
   Chandrasekaran, AM
   Vadiraja, HS
   Raghavendra, R
   Aithal, K
   Champa, R
   Deepak, KK
   Roy, A
   Kinra, S
   Dorairaj, P
AF Patil, Satish G.
   Khode, Vitthal
   Christa, Edmin
   Desai, Rathnamala M.
   Chandrasekaran, Ambalam M.
   Vadiraja, Hosakote S.
   Raghavendra, Rao
   Aithal, Kiran
   Champa, R.
   Deepak, Kishore Kumar
   Roy, Ambuj
   Kinra, Sanjay
   Dorairaj, Prabhakaran
TI Effect of Yoga on Endothelial Function: A Systematic Review and
   Meta-Analysis
SO JOURNAL OF INTEGRATIVE AND COMPLEMENTARY MEDICINE
LA English
DT Review
DE yoga; endothelial function; flow-mediated dilatation; meta-analysis
ID DISEASE RISK-FACTORS; OXIDATIVE STRESS; METABOLIC SYNDROME; VASCULAR
   FUNCTION; 3-MONTH YOGA; BIKRAM YOGA; MEDITATION; CORONARY; DYSFUNCTION;
   INTERVENTION
AB Introduction: Endothelial dysfunction is the initial step in the pathogenesis of atherosclerosis; and it plays a central role in the development of cardiovascular diseases and many types of human diseases (diabetes, kidney failure, cancer, and viral infections). Strategies that are effective in protecting vascular endothelial function and retard or reversing endothelial dysfunction in the early stage appear to be potential in the prevention of vascular, cardiac, and many human diseases. Several studies have been carried out on the effects of yoga on endothelial function, but the results of these studies have not been synthesized. This study aimed at conducting a systematic review and meta-analysis to determine the effectiveness of yoga on endothelial function.Methods: A systematic review and meta-analysis of studies that assessed the effect of yoga practice on vascular endothelial function was done as per the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. The PubMed, Scopus, Google Scholar, and Cochrane controlled register of trials (CENTRAL) were searched from inception to August 2022. The search strategy was constructed around yoga-based techniques and endothelial function. All the yoga-based interventional studies on endothelial function or dysfunction were included in this review. A narrative synthesis and descriptive analysis were done due to the diverse methodology of selected studies. We carried out a formal meta-analysis of controlled trials that assessed the effect of yoga on flow-mediated dilatation (FMD), a measure of endothelial function.Results: A total of 18 studies were included for review involving 1043 participants. Yoga training showed improved endothelial function in 12 studies, whereas 6 studies did not find any statistically robust effect. Meta-analysis (n = 395 participants, 6-studies, 7 comparisons) showed an increase in brachial FMD by yoga practice (mean difference = -1.23%; 95% confidence interval -2.23 to -0.23; p = 0.02). The heterogeneity between the studies was 43% (Tau2 = 0.70, chi 2 = 10.49). The risk of bias was low to moderate in these studies. No adverse effects were reported.Conclusions: Yoga practice improved endothelial function. Yoga could be a safe and potential integrative medicine to improve endothelial function. However, as the statistical heterogeneity, that is, variation in the FMD among the studies was moderate, large clinical trials are necessary for its clinical recommendations.
C1 [Patil, Satish G.; Khode, Vitthal; Desai, Rathnamala M.; Aithal, Kiran; Champa, R.] Shri Dharmasthala Manjunatheshwara Univ, SDM Coll Med Sci & Hosp, Dept Physiol, Dharwad, India.
   [Christa, Edmin; Deepak, Kishore Kumar; Roy, Ambuj] All India Inst Med Sci, New Delhi, India.
   [Christa, Edmin] Govt Yoga & Naturopathy Med Coll & Hosp, Chennai, India.
   [Chandrasekaran, Ambalam M.; Dorairaj, Prabhakaran] Ctr Chron Dis Control, New Delhi, India.
   [Vadiraja, Hosakote S.; Raghavendra, Rao] Cent Council Res Yoga & Naturopathy, New Delhi, India.
   [Kinra, Sanjay] London Sch Hyg & Trop Med, London, England.
   [Dorairaj, Prabhakaran] Publ Hlth Fdn India, New Delhi, India.
   [Patil, Satish G.] SDM Coll Med Sci & Hosp, Dept Physiol, Lab Adv Res Yoga & Vasc Physiol Yoga VPRL, Dharwad 580009, Karnataka, India.
C3 All India Institute of Medical Sciences (AIIMS) New Delhi; University of
   London; London School of Hygiene & Tropical Medicine; Public Health
   Foundation of India
RP Patil, SG (corresponding author), SDM Coll Med Sci & Hosp, Dept Physiol, Lab Adv Res Yoga & Vasc Physiol Yoga VPRL, Dharwad 580009, Karnataka, India.
EM satish.patil@sdmuniversity.edu.in
RI Aithal, Kiran/LCD-5429-2024; Prabhakaran, Dorairaj/B-4147-2011; Raj,
   Vadi Raj/ABA-7015-2021; Chandrasekaran, Ambalam M/JZU-0255-2024; .,
   Champa R./I-7678-2016; Patil, Satish/N-9579-2013
OI Aithal, Kiran/0000-0002-0323-5679; ., Champa R./0000-0002-6002-3031;
   Patil, Satish/0000-0001-8502-0884
FU Shri Dharmasthala Manjunatheshwara University; MRC [MR/J000175/1]
   Funding Source: UKRI
FX The authors are thankful to Shri Dharmasthala Manjunatheshwara
   University for the partial support to this project.
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NR 56
TC 2
Z9 2
U1 2
U2 6
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 2768-3605
EI 2768-3613
J9 J INTEGR COMPLEMENT
JI J. Integr. Complement. Med.
PD MAR 1
PY 2024
VL 30
IS 3
BP 233
EP 249
DI 10.1089/jicm.2023.0189
EA OCT 2023
PG 17
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA LM2C9
UT WOS:001139377100001
PM 37878297
DA 2025-06-11
ER

PT J
AU Abdulan, IM
   Popescu, G
   Mastaleru, A
   Oancea, A
   Costache, AD
   Cojocaru, DC
   Cumpat, CM
   Ciuntu, BM
   Rusu, B
   Leon, MM
AF Abdulan, Irina Mihaela
   Popescu, Gabriela
   Mastaleru, Alexandra
   Oancea, Andra
   Costache, Alexandru Dan
   Cojocaru, Doina-Clementina
   Cumpat, Carmen-Marinela
   Ciuntu, Bogdan Mihnea
   Rusu, Bogdan
   Leon, Maria Magdalena
TI Winter Holidays and Their Impact on Eating Behavior-A Systematic Review
SO NUTRIENTS
LA English
DT Review
DE overeating; holidays; obesity; weight loss
ID BODY-MASS INDEX; WEIGHT-GAIN; FAST-FOOD; INDULGENCE; MANAGEMENT;
   CHRISTMAS; COOKING; OBESITY; STRESS; ADULTS
AB (1) Background: There has been a growing interest in understanding the causes of obesity and developing effective prevention strategies. Lifestyle change programs are often considered the gold standard for weight reduction, and they can help individuals with obesity achieve an annual weight loss of around 8-10%. The aim of this review was to evaluate the effect of food during the winter holidays. This knowledge will serve as a valuable foundation for the development of targeted interventions and prevention programs. (2) Methods: We conducted a systematic search of the literature via one database (PubMed). The search was limited to studies published in English in the last 10 years, with adult participants, but without specifying limits regarding the study design. We excluded articles that addressed intermittent fasting diets or weight loss intervention methods during the holidays through various diets. (3) In separate sections, we analyzed the psychological causes of gaining weight during the winter holidays, behavioral patterns, prevention strategies and the nutritional composition of the different types of food served during the festive period. Results: Using the combination of the terms "holiday and obesity", "holiday and weight gain", "festive season and obesity", and "festive season and weight gain" we obtained 216 results involving the addressed topic. Thus, only ten articles remained after screening, with a total of 4627 participants. Most participants experienced weight fluctuations during the study period, particularly during holidays. One concerning observation was that most of the weight gained during these periods was maintained even after the end of the studies, especially in those with obesity. A supervised exercise program and a controlled diet at work over the Christmas period are effective strategies for avoiding weight gain and its deleterious effects in people with metabolic syndrome or weight problems. (4) In addition, attention must be focused on the psycho-social factors during the holidays because for some people it is a stressful period and can cause a much higher caloric consumption. The simplest method to approach during the holidays is to implement small tips and tricks during this period that will prevent individuals from gaining extra pounds. Conclusions: It is essential to acknowledge that obesity is a multifaceted condition that requires a comprehensive and multidisciplinary approach to address its underlying factors and provide ongoing assistance to individuals in their weight-management endeavors. Even the most effective short-term interventions are likely to produce continued positive outcomes with persistent intervention and support.
C1 [Abdulan, Irina Mihaela; Mastaleru, Alexandra; Oancea, Andra; Costache, Alexandru Dan; Cojocaru, Doina-Clementina; Cumpat, Carmen-Marinela; Leon, Maria Magdalena] Grigore T Popa Univ Med & Pharm, Dept Med Specialties 1, Iasi 700115, Romania.
   [Abdulan, Irina Mihaela; Popescu, Gabriela; Mastaleru, Alexandra; Oancea, Andra; Costache, Alexandru Dan; Cojocaru, Doina-Clementina; Cumpat, Carmen-Marinela; Leon, Maria Magdalena] Clin Rehabil Hosp, Iasi 700661, Romania.
   [Ciuntu, Bogdan Mihnea] Grigore T Popa Univ Med & Pharm, Dept Gen Surg, Univ St 16, Iasi 700115, Romania.
   [Rusu, Bogdan] Gheorghe Asachi Tech Univ Iasi, Fac Ind Design & Business Management, Iasi 700050, Romania.
C3 Grigore T Popa University of Medicine & Pharmacy; Grigore T Popa
   University of Medicine & Pharmacy; GH Asachi Technical University
RP Mastaleru, A; Oancea, A (corresponding author), Grigore T Popa Univ Med & Pharm, Dept Med Specialties 1, Iasi 700115, Romania.; Mastaleru, A; Oancea, A (corresponding author), Clin Rehabil Hosp, Iasi 700661, Romania.
EM irina.abdulan@yahoo.com; popescu_gabriela96@yahoo.com;
   alexandra.mastaleru@gmail.com; andra.radulescu@yahoo.com;
   adcostache@yahoo.com; clementina.cojocaru@gmail.com;
   marinela.cumpat@umfiasi.ro; bogdan-mihnea.ciuntu@umfiasi.ro;
   bogdan.rusu@academic.tuiasi.ro; leon_mariamagdalena@yahoo.com
RI Ciuntu, Bogdan/MTF-9477-2025; Popescu, Gabriela/LPP-7515-2024; Leon,
   Maria/AAP-5791-2021; Abdulan, Irina/AAA-3089-2020; Oancea,
   Andra/IAN-9148-2023; Rusu, Bogdan/F-9081-2017; CUMPAT,
   CARMEN/JZE-3747-2024; Mastaleru, Alexandra/HFZ-8523-2022; Cojocaru,
   Doina-Clementina/U-9853-2017
OI CUMPAT, CARMEN/0000-0002-2564-537X; Oancea, Andra/0000-0003-1356-9581;
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   Alexandra/0000-0002-0008-9696; Costache,
   Alexandru-Dan/0000-0001-8544-9904; Cojocaru,
   Doina-Clementina/0000-0003-1286-5979
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NR 95
TC 10
Z9 10
U1 6
U2 18
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD OCT
PY 2023
VL 15
IS 19
AR 4201
DI 10.3390/nu15194201
PG 29
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA U2HZ1
UT WOS:001083079100001
PM 37836485
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Kim, J
   Baek, Y
   Jeong, K
   Lee, S
AF Kim, Jieun
   Baek, Younghwa
   Jeong, Kyoungsik
   Lee, Siwoo
TI Association of Dietary Factors With Grip Strength, Body Fat, and
   Prevalence of Sarcopenic Obesity in Rural Korean Elderly With
   Cardiometabolic Multimorbidity
SO FRONTIERS IN NUTRITION
LA English
DT Article
DE diet; elderly; macronutrients; sarcopenic obesity; cardiometabolic
   multimorbidity
ID METABOLIC SYNDROME; CARDIOVASCULAR-DISEASE; CARBOHYDRATE INTAKE;
   PROTEIN-INTAKE; OLDER-ADULTS; HEALTH-CARE; MUSCLE MASS; ALL-CAUSE;
   QUALITY; RISK
AB Background and AimsAging accompanied by cardiometabolic multimorbidity (CM) promotes chronic low-grade inflammation, increased oxidative stress, and insulin resistance (IR), which result in loss of muscle mass and functional impairment. Better quality diets have been directly associated with muscle health and decreased risk of all-cause mortality. However, no study has investigated the relationship of dietary factors with grip strength, body composition, and prevalence of sarcopenic obesity (SO) in Korean rural residents according to their CM pattern. Therefore, we aimed to examine this association among this population. Materials and MethodsThis cross-sectional study utilized data from 932 rural residents aged >= 65 years. An exploratory tetrachoric factor analysis revealed four multimorbidity patterns: CM, inflammatory disease, respiratory disease, and cancer and other diseases. All participants were categorized into the CM and non-CM groups. Skeletal muscle mass and the prevalence of sarcopenia were estimated using bioelectrical impedance analysis (BIA). Dietary assessment was analyzed using a validated 106-item food frequency questionnaire. Adjusted multiple linear regression and multivariate logistic regression were employed to examine the association of dietary factors with muscle strength, quality, and SO prevalence ratio in elderly participants. ResultsThe mean age of the participants was 71.8 +/- 0.1 years (65.8% women). Dietary fat and protein intake were positively correlated with handgrip strength in women with CM, after adjusting for covariates (p = 0.001). Similarly, protein intake (g/kg) was positively associated with appendicular skeletal muscle mass (ASM; kg/m(2)) and ASM (%) in both sexes in the CM and non-CM groups. Regarding the tertiles of wheat intake (g/d), 2.1-fold increase in SO prevalence ratios [prevalence ratio (PR): 2.149, confidence intervals (CIs): 1.134-4.071] was observed in the highest tertile (T3: 269.1 g/d), compared to the lowest tertile (Q1: 8.6 g/d) in the CM group. Higher tertile of meat intake (T2: 34.8 g/d, T3: 99.5 g/d) had a 2-fold increase in SO (PR: 1.932, CIs: 1.066-3.500) compared to the lowest tertile (T1: 9.2 g/d) in the CM group. ConclusionOverconsumption of wheat and meat negatively impacted the development of SO, while protein intake was positively associated with grip strength and skeletal muscle mass in elderly Koreans with CM.
C1 [Kim, Jieun; Baek, Younghwa; Jeong, Kyoungsik; Lee, Siwoo] Korea Inst Oriental Med, Div Korean Med Data, Daejeon, South Korea.
C3 Korea Institute of Oriental Medicine (KIOM)
RP Baek, Y; Lee, S (corresponding author), Korea Inst Oriental Med, Div Korean Med Data, Daejeon, South Korea.
EM aori79@kiom.re.kr; ifree72@gmail.com
RI Lee, Jong-Young/M-6319-2013
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NR 66
TC 14
Z9 14
U1 0
U2 8
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD JUL 14
PY 2022
VL 9
AR 910481
DI 10.3389/fnut.2022.910481
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 3K2ZG
UT WOS:000833948900001
PM 35911108
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Yang, B
   Li, M
   Chen, B
   Li, TD
AF Yang, Bo
   Li, Min
   Chen, Bin
   Li, Tian-De
TI Resistin involved in endothelial dysfunction among preclinical Tibetan
   male young adults
SO JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM
LA English
DT Article
DE Resistin; ET-1; endothelial function; preclinical; Tibet
ID INSULIN-RESISTANCE; OXIDATIVE STRESS; OBESITY; ATHEROSCLEROSIS;
   DETERMINANTS; HYPERTENSION; ADIPONECTIN; SENSITIVITY; INHIBITION;
   DISEASE
AB Introduction: Resistin, an adipocyte-derived hormone, was found to be linked to metabolic syndrome and insulin resistance over the past decade. There is growing evidence that resistin plays a potential role in endothelial dysfunction. To the best of our knowledge, few studies have been concerned with the effect of resistin on endothelial function in a Tibetan population.
   Aims: To investigate the correlation of resistin and endothelial function among preclinical Tibetan male young adults.
   Materials and methods: All participants recruited were young adults between 30 and 40 years old of male gender in Lhasa city. All subjects were native Tibetan. A total of 90 healthy subjects were accepted after excluding hypertension, diabetes, hyperlipidemia or coronary artery disease. The subjects were divided into three groups according to flow-mediated dilation (FMD): lower FMD (group A), intermediate FMD (group B) and higher FMD (group C). Body mass index, systolic blood pressure (SBP), diastolic blood pressure (DBP) and cigarette smoking were evaluated. Venous blood was sampled for the measurement of lipid profile, fasting blood glucose (FBG), fasting insulin (FINS), endothelin-1 (ET-1) and plasma resistin quantitation. The non-invasive vascular endothelial function was evaluated through the measurement of FMD with B-mode ultrasound. The insulin resistance was estimated as homeostatic model assessment of insulin resistance (HOMA-IR) = FINS(mu/L)*FBG(mmol/L)/22.5.
   Results: No statistical significance was found between groups in age, smoking, SBP, DBP, fasting insulin, total cholesterol and HOMA-IR (p>0.05). In the lipid profile, high density lipoprotein (HDL) and low density lipoprotein (LDL) cholesterol in group C were better than in groups A and B (p<0.01). Body mass index, which is an indicator for obesity, was much lower in group C than in group A and B (p<0.05 and 0.01 respectively). Comparison of plasma resistin concentrations: group A > group B > group C (p<0.01). Comparison of plasma ET-1 concentrations had a similar result: group A > group B > group C (p<0.05). The multivariate regression analysis showed that total cholesterol (p<0.05), LDL cholesterol (p<0.01), plasma resistin (p<0.01) and plasma ET-1 (p<0.01) were correlated with FMD.
   Conclusions: Resistin is involved in endothelial dysfunction in preclinical male young Tibetan adults.
C1 [Yang, Bo; Li, Tian-De] Chinese Peoples Liberat Army Gen Hosp, Cardiovasc Dept, Beijing 100853, Peoples R China.
   [Li, Min] Chinese Peoples Liberat Army Gen Hosp, Inst Tradit Chinese Med, Beijing 100853, Peoples R China.
   [Chen, Bin] Tibet Gen Hosp, Dept Cardiol, Lhasa, Peoples R China.
C3 Chinese People's Liberation Army General Hospital; Chinese People's
   Liberation Army General Hospital
RP Yang, B (corresponding author), Chinese Peoples Liberat Army Gen Hosp, Dept Cardiol, 28 Fu Xing Rd, Beijing 100853, Peoples R China.
EM dryangb@yahoo.com.cn
FU Beijing Nova Program from the Beijing Municipal Science and Technology
   Commission [2008B55]; VB Foundation from the Chinese Medical Association
   [09010500205]
FX This work was supported by Beijing Nova Program (No. 2008B55) from the
   Beijing Municipal Science and Technology Commission, and VB Foundation
   (09010500205) from the Chinese Medical Association.
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NR 35
TC 9
Z9 10
U1 0
U2 10
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1470-3203
EI 1752-8976
J9 J RENIN-ANGIO-ALDO S
JI J. Renin-Angiotensin-Aldosterone Syst.
PD DEC
PY 2012
VL 13
IS 4
BP 420
EP 425
DI 10.1177/1470320312444745
PG 6
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 040EK
UT WOS:000311304100002
PM 22554824
DA 2025-06-11
ER

PT J
AU Motawi, TMK
   Hashem, RM
   Rashed, LA
   Abd El-Razek, SM
AF Motawi, Tarek M. Kamal
   Hashem, Reem M.
   Rashed, Laila A.
   Abd El-Razek, Sabry M.
TI Comparative study between the effect of the peroxisome proliferator
   activated receptor-α ligands fenofibrate and n-3 polyunsaturated fatty
   acids on activation of 5′-AMP-activated protein kinase-α1 in high-fat
   fed rats
SO JOURNAL OF PHARMACY AND PHARMACOLOGY
LA English
DT Article
DE AMPK-alpha 1; CPT-1; diabetes mellitus; fenofibrate; PPAR-alpha
ID SKELETAL-MUSCLE; GLUCOSE-TRANSPORT; METABOLIC SYNDROME; OBESE RATS;
   KINASE; INSULIN; GLUT4; ADIPOSITY; EXPRESSION; INCREASES
AB Objectives Obesity is a risk factor for type 2 diabetes mellitus. It results from an energy imbalance in which energy intake exceeds energy expenditure. The cellular fuel gauge 5'-AMP-activated protein kinase (AMPK) is a heterotrimeric protein consisting of one catalytic subunit (alpha) and two non-catalytic subunits (beta and gamma), and approximately equal levels of alpha 1 and alpha 2 complexes are present in the liver. AMPK regulates metabolic pathways in response to metabolic stress and in particular ATP depletion to switch on energy-producing catabolic pathways such as beta-oxidation of fatty acids and switch off energy-depleting processes such as synthesis of fatty acid and cholesterol. A high-fat diet alters AMPK-alpha 1 gene expression in the liver and skeletal muscle of rats and results in body weight gain and hyperglycaemia. The aim of this study was to investigate and compare the potential effects of peroxisome proliferator-activated receptor (PPAR)-alpha agonists fenofibrate and n-3 polyunsaturated fatty acids (PUFAs) in modulation of AMPK-alpha 1 activity in liver and skeletal muscle of high-fat diet fed rats.
   Methods Reverse transcription-polymerase chain reaction was used for determination of AMPK-alpha 1 in liver and soleus muscle and both PPAR-alpha and CPT-1 in hepatic tissues. Serum, total cholesterol, triacylglycerol, fatty acid and fasting blood glucose were determined colorimetrically.
   Key findings Both PPAR-alpha agonists, fenofibrate and n-3 PUFA, increased the mRNA expression of AMPK-alpha 1 activity in liver and skeletal muscle of obese diabetic rats. Fenofibrate was superior in its activation of hepatic mRNA expression of AMPK-alpha 1 to exert more lipolytic effect and body weight reduction, as estimated through the decrease of triacylglycerol Output and serum levels of fatty acid on the one hand and the increase in CPT-1 mRNA expression, the key enzyme in beta-oxidation of fatty acid, on the other hand. n-3 PUFA activated AMPK-alpha 1 mRNA expression in skeletal muscle much more than fenofibrate to reveal more hypoglycaemic effect.
   Conclusions The PPAR-alpha agonists fenofibrate and n-3 PUFA could efficiently activate AMPK-alpha 1 mRNA expression in liver and skeletal muscle to exert body weight reduction and hypoglycaemic effect, respectively.
C1 [Hashem, Reem M.] Beni Sueif Univ, Dept Biochem, Fac Pharm, Bani Suwayf 62514, Egypt.
   [Motawi, Tarek M. Kamal] Cairo Univ, Dept Biochem, Fac Pharm, Cairo, Egypt.
   [Rashed, Laila A.] Cairo Univ, Fac Med, Cairo, Egypt.
C3 Egyptian Knowledge Bank (EKB); Beni Suef University; Egyptian Knowledge
   Bank (EKB); Cairo University; Egyptian Knowledge Bank (EKB); Cairo
   University
RP Hashem, RM (corresponding author), Beni Sueif Univ, Dept Biochem, Fac Pharm, Bani Suwayf 62514, Egypt.
EM drreem30@yahoo.com
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NR 47
TC 26
Z9 29
U1 0
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-3573
EI 2042-7158
J9 J PHARM PHARMACOL
JI J. Pharm. Pharmacol.
PD OCT
PY 2009
VL 61
IS 10
BP 1339
EP 1346
DI 10.1211/jpp/61.10.0010
PG 8
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 507RX
UT WOS:000270873400010
PM 19814866
OA Bronze
DA 2025-06-11
ER

PT J
AU Anfossi, CM
   Muñoz, MA
   Fredes, CT
   Rojas, FP
   Ross, J
   Head, J
   Britton, A
AF Moretti Anfossi, Christian
   Ahumada Munoz, Magdalena
   Tobar Fredes, Christian
   Perez Rojas, Felipe
   Ross, Jamie
   Head, Jenny
   Britton, Annie
TI Work Exposures and Development of Cardiovascular Diseases: A Systematic
   Review
SO ANNALS OF WORK EXPOSURES AND HEALTH
LA English
DT Review
DE cardiovascular disease; effort-reward imbalance; job insecurity; job
   strain; long working hours; occupational noise; shift work; systematic
   review
ID CORONARY-HEART-DISEASE; EFFORT-REWARD IMBALANCE; NIGHT-SHIFT WORK;
   MYOCARDIAL-INFARCTION RISK; PERCEIVED JOB INSECURITY; DECISION LATITUDE;
   FOLLOW-UP; PSYCHOSOCIAL FACTORS; OCCUPATIONAL STRESS; METABOLIC SYNDROME
AB Introduction Cardiovascular diseases (CVDs) are the number one cause of death, and there is evidence that work exposures could be associated with their development. This study aimed to systematically review observational studies of adults exposed to job strain, effort-reward imbalance, long working hours, job insecurity, shift work, and occupational noise, and assess the association of those work exposures with CVDs. Methods The Navigation Guide framework was applied. The population were adults of working age (18-65), and cohort and case-control studies were included. The work exposures were job strain, effort-reward imbalance, long working hours, job insecurity, shift work, and occupational noise. The outcomes were cerebrovascular diseases, ischaemic heart disease, and hypertensive diseases. The selection, data extraction, risk of bias assessment, and quality assessment were carried out by two reviewers independently and disagreements were solved by a third reviewer or by consensus. The synthesis of the results was done by applying the 'vote counting based on direction' method, and the results were summarized in an effect direction plot. The strength of the evidence for every risk factor and CVD was defined by consensus. Results A total of 17 643 papers were initially identified in the literature search, but after applying the filters by title and abstract, and full text, 86 studies were finally included. From the included studies, sufficient evidence was found of the harmfulness of job strain for cerebrovascular disease and ischemic heart disease. Furthermore, there was sufficient evidence of the harmfulness of shift work for ischemic heart disease. Evidence of no relationship was found between long working hours and shift work with ischaemic heart disease and hypertensive disease, respectively. The other associations of work exposures and CVDs had limited or inadequate evidence of harmfulness. Conclusions In this comprehensive review, there was sufficient evidence of a harmful relationship between job strain, shift work, and CVDs. For the other work exposures, more high-quality studies are needed. In order to improve current prevention strategies for CVDs, the findings of this review imply that job strain and shift work are work exposures that constitute additional risk factors that could be approached as targets for worksite interventions. Systematic review registration PROSPERO CRD42020179972.
C1 [Moretti Anfossi, Christian; Head, Jenny; Britton, Annie] UCL, Dept Epidemiol & Publ Hlth, 1-19 Torrington Pl, London WC1E 7HB, England.
   [Ahumada Munoz, Magdalena] Inst Salud Publ Chile, Av Marathon 1000, Santiago 7780050, Chile.
   [Tobar Fredes, Christian] Univ San Sebastian, Fac Ciencias Salud, Campus Los Leones,Lota 2465, Santiago 7510157, Chile.
   [Perez Rojas, Felipe] Univ Mayor Sede Temuco, Av Alemania 281, Temuco 4801043, Chile.
   [Ross, Jamie] UCL, Dept Primary Care & Populat Hlth, Rowland Hill St, London NW3 2PF, England.
C3 University of London; University College London; Universidad San
   Sebastian; Universidad Mayor; University of London; University College
   London
RP Anfossi, CM (corresponding author), UCL, Dept Epidemiol & Publ Hlth, 1-19 Torrington Pl, London WC1E 7HB, England.
EM christian.anfossi.19@ucl.ac.uk
RI Ahumada, Magdalena/MCY-7179-2025; Head, Jenny/GYA-2625-2022
OI Moretti Anfossi, Christian/0000-0001-6366-6561; Ahumada,
   Magdalena/0000-0003-2838-0458; Ross, Jamie Anne
   Dolan/0000-0001-8720-5911; Head, Jennifer/0000-0002-6054-0872
FU National Research and Development Agency of Chile; University College
   London; MRC [MR/M006638/1] Funding Source: UKRI
FX This study has been funded by the National Research and Development
   Agency of Chile (ANID), and the University College London.
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NR 104
TC 15
Z9 15
U1 2
U2 15
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 2398-7308
EI 2398-7316
J9 ANN WORK EXPOS HEAL
JI Ann. Work Expos. Health
PD JUL 2
PY 2022
VL 66
IS 6
BP 698
EP 713
DI 10.1093/annweh/wxac004
EA MAR 2022
PG 16
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA 2P6PL
UT WOS:000763100400001
PM 35237787
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Nunn, AVW
   Guy, GW
   Bell, JD
AF Nunn, Alistair Victor William
   Guy, Geoffrey William
   Bell, Jimmy David
TI Thermodynamics and Inflammation: Insights into Quantum Biology and
   Ageing
SO QUANTUM REPORTS
LA English
DT Review
DE quantum biology; thermodynamics; ageing; inflammation; mitochondria;
   hormesis
ID OXYGEN SPECIES PRODUCTION; CALORIE RESTRICTION; MITOCHONDRIAL DYNAMICS;
   TRANSPOSABLE ELEMENTS; UNCOUPLING PROTEINS; METABOLIC SYNDROME;
   ELECTRON-TRANSFER; CELL-DEATH; LIFE-SPAN; KAPPA-B
AB Inflammation as a biological concept has been around a long time and derives from the Latin "to set on fire" and refers to the redness and heat, and usually swelling, which accompanies injury and infection. Chronic inflammation is also associated with ageing and is described by the term "inflammaging". Likewise, the biological concept of hormesis, in the guise of what "does not kill you, makes you stronger", has long been recognized, but in contrast, seems to have anti-inflammatory and age-slowing characteristics. As both phenomena act to restore homeostasis, they may share some common underlying principles. Thermodynamics describes the relationship between heat and energy, but is also intimately related to quantum mechanics. Life can be viewed as a series of self-renewing dissipative structures existing far from equilibrium as vortexes of "negentropy" that ages and dies; but, through reproduction and speciation, new robust structures are created, enabling life to adapt and continue in response to ever changing environments. In short, life can be viewed as a natural consequence of thermodynamics to dissipate energy to restore equilibrium; each component of this system is replaceable. However, at the molecular level, there is perhaps a deeper question: is life dependent on, or has it enhanced, quantum effects in space and time beyond those normally expected at the atomistic scale and temperatures that life operates at? There is some evidence it has. Certainly, the dissipative adaptive mechanism described by thermodynamics is now being extended into the quantum realm. Fascinating though this topic is, does exploring the relationship between quantum mechanics, thermodynamics, and biology give us a greater insight into ageing and, thus, medicine? It could be said that hormesis and inflammation are expressions of thermodynamic and quantum principles that control ageing via natural selection that could operate at all scales of life. Inflammation could be viewed as a mechanism to remove inefficient systems in response to stress to enable rebuilding of more functional dissipative structures, and hormesis as the process describing the ability to adapt; underlying this is the manipulation of fundamental quantum principles. Defining what "quantum biological normality" is has been a long-term problem, but perhaps we do not need to, as it is simply an expression of one end of the normal quantum mechanical spectrum, implying that biology could inform us as to how we can define the quantum world.
C1 [Nunn, Alistair Victor William; Bell, Jimmy David] Univ Westminster, Res Ctr Optimal Hlth, Dept Life Sci, London W1W 6UW, England.
   [Guy, Geoffrey William] Guy Fdn, Dorset DT8 3HY, England.
C3 University of Westminster
RP Nunn, AVW (corresponding author), Univ Westminster, Res Ctr Optimal Hlth, Dept Life Sci, London W1W 6UW, England.
EM a.nunn@westminster.ac.uk; gwg@theguyfoundation.org;
   j.bell@westminster.ac.uk
OI Nunn, Alistair/0000-0003-0728-1995; Bell, Jimmy/0000-0003-3804-1281
FU Guy Foundation
FX FundingThe writing of this manuscript was supported by the Guy
   Foundation.
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NR 179
TC 6
Z9 6
U1 2
U2 2
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2624-960X
J9 QUANTUM REP
JI Quantum Rep.
PD MAR
PY 2022
VL 4
IS 1
BP 47
EP 74
DI 10.3390/quantum4010005
PG 28
WC Quantum Science & Technology
WE Emerging Sources Citation Index (ESCI)
SC Physics
GA P6E0T
UT WOS:001378805900001
OA Green Published, gold, Green Accepted
DA 2025-06-11
ER

PT J
AU Barragán, R
   Sánchez-González, C
   Aranda, P
   Sorlí, J
   Asensio, EM
   Portolés, O
   Ortega-Azorín, C
   Villamil, LV
   Coltell, O
   Llopis, J
   Rivas-García, L
   Corella, D
AF Barragan, Rocio
   Sanchez-Gonzalez, Cristina
   Aranda, Pilar
   Sorli, Jose, V
   Asensio, Eva M.
   Portoles, Olga
   Ortega-Azorin, Carolina
   Villamil, Laura V.
   Coltell, Oscar
   Llopis, Juan
   Rivas-Garcia, Lorenzo
   Corella, Dolores
TI Single and Combined Associations of Plasma and Urine Essential Trace
   Elements (Zn, Cu, Se, and Mn) with Cardiovascular Risk Factors in a
   Mediterranean Population
SO ANTIOXIDANTS
LA English
DT Article
DE zinc; copper; selenium; manganese; cardiovascular risk factors; mixture;
   quantile-g-computation
ID CORONARY-HEART-DISEASE; DAILY DIETARY-INTAKE; OXIDATIVE STRESS; ZINC
   STATUS; SELENIUM STATUS; EXPOSURE BIOMARKER; METABOLIC SYNDROME;
   GLYCEMIC CONTROL; FORTIFIED FOODS; HEAVY-METALS
AB Trace elements are micronutrients that are required in very small quantities through diet but are crucial for the prevention of acute and chronic diseases. Despite the fact that initial studies demonstrated inverse associations between some of the most important essential trace elements (Zn, Cu, Se, and Mn) and cardiovascular disease, several recent studies have reported a direct association with cardiovascular risk factors due to the fact that these elements can act as both antioxidants and pro-oxidants, depending on several factors. This study aims to investigate the association between plasma and urine concentrations of trace elements and cardiovascular risk factors in a general population from the Mediterranean region, including 484 men and women aged 18-80 years and considering trace elements individually and as joint exposure. Zn, Cu, Se, and Mn were determined in plasma and urine using an inductively coupled plasma mass spectrometer (ICP-MS). Single and combined analysis of trace elements with plasma lipid, blood pressure, diabetes, and anthropometric variables was undertaken. Principal component analysis, quantile-based g-computation, and calculation of trace element risk scores (TERS) were used for the combined analyses. Models were adjusted for covariates. In single trace element models, we found statistically significant associations between plasma Se and increased total cholesterol and systolic blood pressure; plasma Cu and increased triglycerides and body mass index; and urine Zn and increased glucose. Moreover, in the joint exposure analysis using quantile g-computation and TERS, the combined plasma levels of Zn, Cu, Se (directly), and Mn (inversely) were strongly associated with hypercholesterolemia (OR: 2.03; 95%CI: 1.37-2.99; p < 0.001 per quartile increase in the g-computation approach). The analysis of urine mixtures revealed a significant relationship with both fasting glucose and diabetes (OR: 1.91; 95%CI: 1.01-3.04; p = 0.046). In conclusion, in this Mediterranean population, the combined effect of higher plasma trace element levels (primarily Se, Cu, and Zn) was directly associated with elevated plasma lipids, whereas the mixture effect in urine was primarily associated with plasma glucose. Both parameters are relevant cardiovascular risk factors, and increased trace element exposures should be considered with caution.
C1 [Barragan, Rocio; Sorli, Jose, V; Asensio, Eva M.; Portoles, Olga; Ortega-Azorin, Carolina; Corella, Dolores] Univ Valencia, Sch Med, Dept Prevent Med & Publ Hlth, Valencia 46010, Spain.
   [Barragan, Rocio; Sorli, Jose, V; Asensio, Eva M.; Portoles, Olga; Ortega-Azorin, Carolina; Coltell, Oscar; Corella, Dolores] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr, Madrid 28029, Spain.
   [Sanchez-Gonzalez, Cristina; Aranda, Pilar; Llopis, Juan; Rivas-Garcia, Lorenzo] Univ Granada, Sport & Hlth Res Ctr, Granada 18016, Spain.
   [Sanchez-Gonzalez, Cristina; Aranda, Pilar; Llopis, Juan; Rivas-Garcia, Lorenzo] Inst Nutr & Food Technol Jose Mataix, Biomed Res Ctr, Dept Physiol, Granada 18100, Spain.
   [Ortega-Azorin, Carolina; Coltell, Oscar] Univ Jaume 1, Dept Comp Languages & Syst, Castellon de La Plana 12071, Spain.
   [Villamil, Laura V.] Univ Antonio Narino, Sch Med, Dept Physiol, Bogota 111511, Colombia.
C3 University of Valencia; Instituto de Salud Carlos III; CIBER - Centro de
   Investigacion Biomedica en Red; CIBEROBN; University of Granada;
   Universitat Jaume I; Universidad Antonio Narino
RP Barragán, R; Corella, D (corresponding author), Univ Valencia, Sch Med, Dept Prevent Med & Publ Hlth, Valencia 46010, Spain.; Barragán, R; Corella, D (corresponding author), Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr, Madrid 28029, Spain.
EM rocio.barragan@uv.es; dolores.corella@uv.es
RI García, Lorenzo/ABD-6217-2020; LLOPIS, juan/JQV-8992-2023; Sorlí,
   José/L-8758-2014; Coltell, Oscar/AAA-9936-2019; Reparaz,
   Olga/AAB-3243-2019; Coltell, Oscar/L-8549-2014; Sanchez Gonzalez,
   Cristina/Q-6219-2017; Aranda Ramirez, Pilar/B-8037-2016; Corella,
   Dolores/L-9888-2014
OI Coltell, Oscar/0000-0002-4518-8495; Sanchez Gonzalez,
   Cristina/0000-0002-1044-4858; CAROLINA,
   ORTEGA-AZORIN/0000-0001-6719-9358; Aranda Ramirez,
   Pilar/0000-0002-7982-1359; Corella, Dolores/0000-0002-2366-4104;
   Asensio, Eva Maria/0000-0003-4558-0988; Rivas Garcia,
   Lorenzo/0000-0002-0413-8432; Barragan-Arnal, Rocio/0000-0001-8072-3791;
   Sorli, Jose V/0000-0002-0130-2006
FU Spanish Ministry of Health (Instituto de Salud Carlos III); Ministerio
   de Economia y Competitividad-Fondo Europeo de Desarrollo Regional
   (FEDER) [CIBER 06/03, SAF2016-80532-R]; Junta de Andalucia [AGR145];
   Generalitat Valenciana [PROMETEO2017/017, APOSTD/2019/136,
   PROMETEO/2021/021]; ERDF A way of making Europe; AEI
   [PID2019-108858RB-I00]
FX This study was partially funded, by the Spanish Ministry of Health
   (Instituto de Salud Carlos III) and the Ministerio de Economia y
   Competitividad-Fondo Europeo de Desarrollo Regional (FEDER) (grants
   CIBER 06/03, SAF2016-80532-R); the Junta de Andalucia (AGR145 research
   group); and the Generalitat Valenciana (grants PROMETEO2017/017,
   APOSTD/2019/136, and PROMETEO/2021/021); grant PID2019-108858RB-I00
   funded by AEI 10.13039/501100011033 and by "ERDF A way of making
   Europe".
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NR 184
TC 15
Z9 16
U1 1
U2 28
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD OCT
PY 2022
VL 11
IS 10
AR 1991
DI 10.3390/antiox11101991
PG 29
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA 5N8YP
UT WOS:000872074000001
PM 36290714
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Lin, M
   Mao, ZJ
AF Lin, Min
   Mao, Zhu-Jun
TI lncRNA-mRNA competing endogenous RNA network in IR-hepG2 cells
   ameliorated by APBBR decreasing ROS levels: a systematic analysis
SO PEERJ
LA English
DT Article
DE Astragalus polysaccharide combined with berberine; Insulin resistance;
   IR-HepG2 cell model; ROS; Long non-coding RNA; Messenger RNA; Competing
   endogenous RNA network
ID INSULIN-RESISTANCE; METABOLIC SYNDROME; ASSOCIATION; STRESS; LONG
AB Background. Radix Astragali (Astragalus membranaceus var. mongholicus (Bunge)) and Coptis chinensis (Coptis chinensis var. angustiloba) are two commonly prescribed traditional Chinese herbs for diabetes. Astragalus Polysaccharide (AP) and Berberine (BBR) are active ingredients of these two herbs respectively and they are scientifically proved to have immunomodulatory and anti-inflammatory effects. They are also known for their antidiabetic potential by ameliorating insulin resistance (IR). AP and BBR have shown different advantages in treating diabetes according to previous reports. However, very few studies focus on the combined activities of the two potential antidiabetic ingredients. In this study, we discovered that reactive oxygen species (ROS) accumulated in IR-hepG2 cells and APBBR can decrease ROS level in model group significantly. We conjectured that APBBR can ameliorate IR in hepG2 cells by decreasing ROS level. In order to verify this hypothesis, we obtained phenotype and transcriptome information of IR-HepG2 cells and explore the underlying mechanism of the combination of AP and BBR(APBBR) activity on the relationship between ROS change in IR at whole-transcriptome level, so as to shed new light to efficacy and application of APBBR in treating diabetes.
   Methods. The IR cell model was established with high-level insulin intervention. Glucose content, HepG2 cell viability as well as ROS level was detected to study the effect of IR-hepG2 cell phenotype. Unbiased genome-wide RNA sequencing was used to investigate alterations in experimental groups. Then, GO and KEGG functional enrichment was performed to explore the function and pathway of target genes. Venn analysis found out the differentially expressed lncRNAs that had close relationship with IR and ROS. Finally, we screened out candidate lncRNAs and these target genes to construct interaction network of differentiated lncRNA-miRNA-mRNA
   Results. The biochemical experiments showed that APBBR administration could improve the proliferation activity of IR-HepG2 cells and decrease ROS level in model cells. The GO and KEGG functional enrichment analyses demonstrated several mRNAs remarkably enriched in biological processes and signaling pathways related to ROS production and IR progression. Interaction network suggest that APBBR ameliorates IR in HepG2 cells by regulating the expression of multiple genes and activating relevant signaling pathway to decrease ROS level. Thus, we demonstrated that APBBR ameliorated IR in hepG2 cells via the ROS-dependent pathway.
C1 [Lin, Min] Zhejiang Chinese Med Univ, Coll Basic Med, Hangzhou, Peoples R China.
   [Mao, Zhu-Jun] Zhejiang Chinese Med Univ, Coll Pharmaceut Sci, Hangzhou, Peoples R China.
C3 Zhejiang Chinese Medical University; Zhejiang Chinese Medical University
RP Mao, ZJ (corresponding author), Zhejiang Chinese Med Univ, Coll Pharmaceut Sci, Hangzhou, Peoples R China.
EM maozhu-jun0107@zcmu.cdu.cn
RI min, lin/AAJ-7325-2020
FU National Natural Science Foundation of China [81603351]
FX This study was supported by the grants from the National Natural Science
   Foundation of China (No. 81603351). The funders had no role in study
   design, data collection and analysis, decision to publish, or
   preparation of the manuscript.
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NR 41
TC 9
Z9 11
U1 1
U2 28
PU PEERJ INC
PI LONDON
PA 341-345 OLD ST, THIRD FLR, LONDON, EC1V 9LL, ENGLAND
SN 2167-8359
J9 PEERJ
JI PeerJ
PD FEB 24
PY 2020
VL 8
AR e8604
DI 10.7717/peerj.8604
PG 20
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA KO5FK
UT WOS:000515575000003
PM 32140303
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Foote, CA
   Castorena-Gonzalez, JA
   Ramirez-Perez, FI
   Jia, GH
   Hill, MA
   Reyes-Aldasoro, CC
   Sowers, JR
   Martinez-Lemus, LA
AF Foote, Christopher A.
   Castorena-Gonzalez, Jorge A.
   Ramirez-Perez, Francisco I.
   Jia, Guanghong
   Hill, Michael A.
   Reyes-Aldasoro, Constantino C.
   Sowers, James R.
   Martinez-Lemus, Luis A.
TI Arterial Stiffening in Western Diet-Fed Mice Is Associated with
   Increased Vascular Elastin, Transforming Growth Factor-β, and Plasma
   Neuraminidase
SO FRONTIERS IN PHYSIOLOGY
LA English
DT Article
DE vascular compliance; neuraminidase; TGF-beta; vascular remodeling;
   overnutrition
ID HOMEOSTASIS MODEL ASSESSMENT; INSULIN-RESISTANCE; LUNG FIBROBLASTS;
   TGF-BETA; ENDOTHELIAL DYSFUNCTION; DIASTOLIC DYSFUNCTION; INCREASED
   STIFFNESS; VISCERAL ADIPOSITY; METABOLIC SYNDROME; AORTIC STIFFNESS
AB Consumption of excess fat and carbohydrate (Western diet, WD) is associated with alterations in the structural characteristics of blood vessels. This vascular remodeling contributes to the development of cardiovascular disease, particularly as it affects conduit and resistance arteries. Vascular remodeling is often associated with changes in the elastin-rich internal elastic lamina (IEL) and the activation of transforming growth factor (TGF)-beta. In addition, obesity and type II diabetes have been associated with increased serum neuraminidase, an enzyme known to increase TGF-beta cellular output. Therefore, we hypothesized that WD-feeding would induce structural modifications to the IEL of mesenteric resistance arteries in mice, and that these changes would be associated with increased levels of circulating neuraminidase and the up-regulation of elastin and TGF-beta in the arterial wall. To test this hypothesis, a WD, high in fat and sugar, was used to induce obesity in mice, and the effect of this diet on the structure of mesenteric resistance arteries was investigated. 4-week old, Post-weaning mice were fed either a normal diet (ND) or WD for 16 weeks. Mechanically, arteries from WD fed mice were stiffer and less distensible, with marginally increased wall stress for a given strain, and a significantly increased Young's modulus of elasticity. Structurally, the wall cross-sectional area and the number of fenestrae found in the internal elastic lamina (IEL) of mesenteric arteries from mice fed a WD were significantly smaller than those of arteries from the ND fed mice. There was also a significant increase in the volume of elastin, but not collagen in arteries from the WD cohort. Plasma levels of neuraminidase and the amount of TGF-beta in mesenteric arteries were elevated in mice fed a WD, while ex vivo, cultured vascular smooth muscle cells exposed to neuraminidase secreted greater amounts of tropoelastin and TGF-beta than those exposed to vehicle. These data suggest that consumption of a diet high in fat and sugar causes stiffening of the vascular wall in resistance arteries through a process that may involve increased neuraminidase and TGF-beta activity, elevated production of elastin, and a reduction in the size and number of fenestrae in the arterial IEL.
C1 [Foote, Christopher A.; Castorena-Gonzalez, Jorge A.; Ramirez-Perez, Francisco I.; Hill, Michael A.; Martinez-Lemus, Luis A.] Univ Missouri, Dalton Cardiovasc Res Ctr, Columbia, MO 65211 USA.
   [Castorena-Gonzalez, Jorge A.; Ramirez-Perez, Francisco I.; Martinez-Lemus, Luis A.] Univ Missouri, Dept Biol Engn, Columbia, MO 65211 USA.
   [Jia, Guanghong; Sowers, James R.] Univ Missouri, Diabet & Cardiovasc Res Ctr, Columbia, MO USA.
   [Jia, Guanghong; Sowers, James R.] Harry S Truman Mem Vet Hosp, Columbia, MO 65201 USA.
   [Hill, Michael A.; Martinez-Lemus, Luis A.] Univ Missouri, Dept Med Pharmacol & Physiol, Columbia, MO 65211 USA.
   [Reyes-Aldasoro, Constantino C.] City Univ London, Sch Engn & Math Sci, London, England.
C3 University of Missouri System; University of Missouri Columbia;
   University of Missouri System; University of Missouri Columbia;
   University of Missouri System; University of Missouri Columbia; US
   Department of Veterans Affairs; Veterans Health Administration (VHA);
   Harry S. Truman Memorial Veterans' Hospital; University of Missouri
   System; University of Missouri Columbia; City St Georges, University of
   London; City, University of London
RP Martinez-Lemus, LA (corresponding author), Univ Missouri, Dalton Cardiovasc Res Ctr, Columbia, MO 65211 USA.; Martinez-Lemus, LA (corresponding author), Univ Missouri, Dept Biol Engn, Columbia, MO 65211 USA.; Martinez-Lemus, LA (corresponding author), Univ Missouri, Dept Med Pharmacol & Physiol, Columbia, MO 65211 USA.
EM martinezlemusl@missouri.edu
RI Ramirez-Perez, Francisco/HSC-3380-2023; Reyes-Aldasoro,
   Constantino/S-5093-2019; Hill, Michael/AAV-5350-2020
OI Castorena-Gonzalez, Jorge/0000-0001-5252-375X; Hill,
   Michael/0000-0002-4455-2072; Reyes-Aldasoro,
   Constantino/0000-0002-9466-2018
FU National Institutes of Health [HL088105, HL-107910]; Department of
   Veterans Affairs Biomedical Laboratory Research and Development [0018]
FX This work was supported by the National Institutes of Health (HL088105
   to LM and HL-107910 to JS) and Department of Veterans Affairs Biomedical
   Laboratory Research and Development 0018 to JS. The authors thank
   Guiling Zhao and Brady Barron for their excellent technical assistance.
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NR 67
TC 35
Z9 37
U1 0
U2 11
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-042X
J9 FRONT PHYSIOL
JI Front. Physiol.
PD JUL 7
PY 2016
VL 7
AR 285
DI 10.3389/fphys.2016.00285
PG 15
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA DQ7TP
UT WOS:000379411100001
PM 27458385
OA Green Published, Green Accepted, gold
DA 2025-06-11
ER

PT J
AU Grgurevic, I
   Bozin, T
   Mikus, M
   Kukla, M
   O'Beirne, J
AF Grgurevic, Ivica
   Bozin, Tonci
   Mikus, Mislav
   Kukla, Michal
   O'Beirne, James
TI Hepatocellular Carcinoma in Non-Alcoholic Fatty Liver Disease: From
   Epidemiology to Diagnostic Approach
SO CANCERS
LA English
DT Review
DE hepatocellular carcinoma; non-alcoholic fatty liver disease; metabolic
   syndrome; diabetes mellitus; screening programs; biomarkers; ultrasound
ID ENDOPLASMIC-RETICULUM STRESS; ULTRASOUND SURVEILLANCE; CONFERS
   SUSCEPTIBILITY; INTESTINAL MICROBIOTA; CLINICAL-PATTERNS; WIDE
   ASSOCIATION; PROGENITOR CELLS; GUT MICROBIOTA; RISK-FACTORS; T-CELLS
AB Simple Summary: Non-alcoholic fatty liver disease (NAFLD) is expected to become the leading cause of hepatocellular carcinoma (HCC) in the near future. In this article, we review the current knowledge about the epidemiology, risk factors, pathogenesis, clinical presentation and diagnostic approach to HCC in NAFLD. Knowledge of these facts is of great importance to improve the early identification of patients that are at risk, allowing for early detection of HCC and, thus, an improvement in clinical outcomes. This is especially important given that around 30% of NAFLD-related HCCs develop in a non-cirrhotic liver. The presence of diabetes, male sex, older age and Hispanic race, in addition to liver cirrhosis, are the most important risk factors for HCC in this setting. In summarising the current knowledge of genetic susceptibility, metabolic derangements and immunological mechanisms involved in the pathogenesis of NAFLD-related HCC, we illustrate the need for further research on this intriguing topic.
   Non-alcoholic fatty liver disease (NAFLD) is becoming the leading cause of liver morbidity worldwide and, as such, represents the pathogenic background for the increasing incidence of hepatocellular carcinoma (HCC). The annual incidence of NAFLD-related HCC is expected to increase by 45-130% by 2030. Diabetes mellitus is the most important risk factor for HCC development in NAFLD, with the risk further increased when associated with other metabolic traits, such as obesity, arterial hypertension and dyslipidemia. The highest risk of HCC exists in patients with advanced fibrosis or cirrhosis, although 20-50% of HCC cases arise in NAFLD patients with an absence of cirrhosis. This calls for further investigation of the pathogenic mechanisms that are involved in hepatocarcinogenesis, including genetics, metabolomics, the influence of the gut microbiota and immunological responses. Early identification of patients with or at risk of NAFLD is of utmost importance to improve outcomes. As NAFLD is highly prevalent in the community, the identification of cases should rely upon simple demographic and clinical characteristics. Once identified, these patients should then be evaluated for the presence of advanced fibrosis or cirrhosis and subsequently enter HCC surveillance programs if appropriate. A significant problem is the early recognition of non-cirrhotic NAFLD patients who will develop HCC, where new biomarkers and scores are potential solutions to tackle this issue.
C1 [Grgurevic, Ivica; Bozin, Tonci] Univ Hosp Dubrava, Dept Gastroenterol Hepatol & Clin Nutr, Zagreb 10000, Croatia.
   [Grgurevic, Ivica] Univ Zagreb, Fac Pharm & Biochem, Sch Med, Zagreb 10000, Croatia.
   [Mikus, Mislav] Univ Hosp Ctr Zagreb, Dept Obstet & Gynecol, Zagreb 10000, Croatia.
   [Kukla, Michal] Jagiellonian Univ Med Coll, Fac Med, Dept Internal Med & Geriatr, PL-30688 Krakow, Poland.
   [O'Beirne, James] Univ Sunshine Coast, Dept Hepatol, Sunshine Coast 4556, Australia.
C3 University of Zagreb; University of Zagreb; UNIVERSITY ZAGREB HOSPITAL;
   Jagiellonian University; Collegium Medicum Jagiellonian University;
   University of the Sunshine Coast
RP Grgurevic, I (corresponding author), Univ Hosp Dubrava, Dept Gastroenterol Hepatol & Clin Nutr, Zagreb 10000, Croatia.; Grgurevic, I (corresponding author), Univ Zagreb, Fac Pharm & Biochem, Sch Med, Zagreb 10000, Croatia.
EM ivica.grgurevic@zg.htnet.hr; tbozin@kbd.hr; mmikus@mef.hr;
   michal.kukla@uj.edu.pl; jobeirne@usc.edu.au
RI Grgurevic, Ivica/AEN-2615-2022; Kukla, Michal/ABH-8665-2020; O'Beirne,
   James/I-8251-2019
OI O'Beirne, James/0000-0003-3400-2816
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NR 144
TC 41
Z9 41
U1 1
U2 6
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6694
J9 CANCERS
JI Cancers
PD NOV
PY 2021
VL 13
IS 22
AR 5844
DI 10.3390/cancers13225844
PG 20
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA 0A4HQ
UT WOS:000773917700042
PM 34830997
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Imran, A
   Butt, MS
   Arshad, MS
   Arshad, MU
   Saeed, F
   Sohaib, M
   Munir, R
AF Imran, Ali
   Butt, Masood Sadiq
   Arshad, Muhammad Sajid
   Arshad, Muhammad Umair
   Saeed, Farhan
   Sohaib, Muhammad
   Munir, Rizwan
TI Exploring the potential of black tea based flavonoids against
   hyperlipidemia related disorders
SO LIPIDS IN HEALTH AND DISEASE
LA English
DT Article
DE Hyperlipidemia; Dietary interventions; Flavonoids; Thearubigins
ID INTESTINAL-ABSORPTION; LIPID-METABOLISM; RATS; CHOLESTEROL; GREEN;
   GLUCOSE; DIET; TRIGLYCERIDE; POLYPHENOLS; CONSUMPTION
AB Background: In recent decade, Hyperlipidemia related disorders like obesity, hypercholesterolemia and diabetes are considered as the leading killers for mankind. Fundamental nexus between nutrition and health diverting the consumers focus towards plant based natural products as a remedy against various metabolic syndrome. Considering this, present study was conducted to explicate the role of black tea polyphenols such as Theaflavins and thearubigins therapeutic potential to tackle targeted maladies especially oxidative stress related disorders like hypercholesterolemia and diabetes.
   Methods: The mandate of current investigation was to explore the hypoglycemic and hypocholestrolemic perspective of isolated theaflavin and thearubigins through a model feeding trial. For the purpose, theaflavin & thearubigins were isolated from black tea through solvent partition method and utilize to form three types of nutraceutical drinks (theaflavin, thearubigins & theaflavin + thearubigins based) alongside control to be further utilized in bioefficacy trial. In bioefficacy trial, three types of independent studies were design on the bases of diet by involving 20 male wistar rats in each study (5 for each group). In study I, normal diet was administrated while, in study II & III high cholesterol and high sucrose diet was given, respectively along with prepared nutraceutical drinks to synchronize their therapeutic effect for a period of 56 days. At the termination of trial, Feed & drink intakes, body weight, total cholesterol, LDL, HDL, triglycerides, glucose and insulin levels were measured.
   Results: The results indicated reduction in cholesterol, LDL and triglycerides levels of experimental rats in all studies with significant increase in HDL. In this context, theaflavin based drink imparted maximum reduction in cholesterol (3.75, 11.03 & 10.39%), LDL (3.84, 14.25&10.84%) & triglycerides (2.99, 8.54 & 6.65%) in respective studies compared to thearubigins and theaflavin + thearubigins based drinks. However, theaflavin+ thearubigins based drink caused highest glucose decline and maximum insulin increase in all studies as compared to other nutraceutical drinks. The reported value for the insulin increase were 13.02 +/- 1.02 & 14.55 +/- 1.13, 10.09 +/- 0.15 & 11.59 +/- 0.86 for Hyperglycemic and Hypocholestrolemic rats respectively compared to control (7.84 +/- 0.45 & 9.10 +/- 0.41) for study I and II.
   Conclusions: In the nutshell, theaflavin and thearubigins based dietary interventions are helpful to alleviate the hypercholestrolemia and hyperglycemia and should be promoted as parallel therapy to combat these disorders.
C1 [Imran, Ali; Arshad, Muhammad Sajid; Arshad, Muhammad Umair; Saeed, Farhan] Govt Coll Univ, Inst Home & Food Sci, Faisalabad 38040, Pakistan.
   [Butt, Masood Sadiq] Univ Agr Faisalabad, Natl Inst Food Sci & Technol, Faisalabad 38040, Pakistan.
   [Sohaib, Muhammad] Univ Vet & Anim Sci, Dept Food Sci & Human Nutr, Lahore 54000, Pakistan.
   [Munir, Rizwan] Govt Coll Univ, Dept Stat, Faisalabad 38040, Pakistan.
C3 Government College University Faisalabad; University of Agriculture
   Faisalabad; University of Veterinary & Animal Science - Pakistan;
   Government College University Faisalabad
RP Arshad, MS (corresponding author), Govt Coll Univ, Inst Home & Food Sci, Faisalabad 38040, Pakistan.
EM sajid_ft@yahoo.com
RI Saeed, Farhan/AAB-9559-2022; Butt, Masood Sadiq/AAZ-8801-2021; Sohaib,
   Muhammad/M-4978-2016; Arshad, Muhammad/D-4269-2011; Arshad,
   Muhammad/AAR-4975-2020; Imran, Ali/J-1316-2019; Saeed,
   Farhan/ABD-2112-2021
OI Sohaib, Muhammad/0000-0003-2743-3706; Saeed, Farhan/0000-0001-5340-4015;
   Butt, Masood Sadiq/0000-0002-5805-8702; Munir,
   Rizwan/0000-0001-9021-3920
FU Higher Education Commission (HEC), Government of Pakistan
FX The authors are grateful to Higher Education Commission (HEC),
   Government of Pakistan for their financial support to carry out the
   present research.
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NR 43
TC 42
Z9 56
U1 1
U2 56
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1476-511X
J9 LIPIDS HEALTH DIS
JI Lipids Health Dis.
PD MAR 27
PY 2018
VL 17
AR 57
DI 10.1186/s12944-018-0688-6
PG 16
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA GA7ZL
UT WOS:000428557500001
PM 29592809
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Guo, FF
   Estévez-Vázquez, O
   Benedé-Ubieto, R
   Maya-Miles, D
   Zheng, K
   Gallego-Durán, R
   Rojas, A
   Ampuero, J
   Romero-Gómez, M
   Philip, K
   Egbuniwe, IU
   Chen, CB
   Simon, J
   Delgado, TC
   Martínez-Chantar, ML
   Sun, J
   Reissing, J
   Bruns, T
   Lamas-Paz, A
   del Moral, MG
   Woitok, MM
   Vaquero, J
   Regueiro, JR
   Liedtke, C
   Trautwein, C
   Bañares, R
   Cubero, FJ
   Nevzorova, YA
AF Guo, Feifei
   Estevez-Vazquez, Olga
   Benede-Ubieto, Raquel
   Maya-Miles, Douglas
   Zheng, Kang
   Gallego-Duran, Rocio
   Rojas, Angela
   Ampuero, Javier
   Romero-Gomez, Manuel
   Philip, Kaye
   Egbuniwe, Isioma U.
   Chen, Chaobo
   Simon, Jorge
   Delgado, Teresa C.
   Martinez-Chantar, Maria Luz
   Sun, Jie
   Reissing, Johanna
   Bruns, Tony
   Lamas-Paz, Arantza
   del Moral, Manuel Gomez
   Woitok, Marius Maximilian
   Vaquero, Javier
   Regueiro, Jose R.
   Liedtke, Christian
   Trautwein, Christian
   Banares, Rafael
   Cubero, Francisco Javier
   Nevzorova, Yulia A.
TI A Shortcut from Metabolic-Associated Fatty Liver Disease (MAFLD) to
   Hepatocellular Carcinoma (HCC): c-MYC a Promising Target for
   Preventative Strategies and Individualized Therapy
SO CANCERS
LA English
DT Article
DE metabolic-associated fatty liver disease (MAFLD); c-myc; oncogene;
   tumorigenesis; metformin
ID METFORMIN; CANCER; NAFLD; PROGRESSION; EXPRESSION; ONCOGENES; MODEL;
   RISK
AB Simple Summary Metabolic-associated fatty liver disease (MAFLD) is a chronic liver disease associated with obesity, diabetes mellitus type 2 (DM2), and hyperlipidemia. It can also progress to end-stage hepatocellular carcinoma (HCC); the underlying mechanisms are still unknown, but endogenous (i.e., genetic) factors such as oncogenes have been suggested to play a role. We found that c-MYC transgenic mice with ageing are prone to develop obesity, metabolic syndrome (MS), and abnormal accumulation of lipids in the liver compared to control mice. A short-term application of the Western diet (WD) significantly worsened the phenotype and accelerate HCC development. Importantly, we found that metformin as therapeutic approach significantly attenuated MAFLD phenotype in transgenic mice. We also observed that c-MYC is up-regulated in human patients with MAFLD and MAFLD-related HCC. Altogether the current study suggests an important role of the oncogene c-MYC during the progression from MAFLD to HCC and makes c-MYC a possible target for preventative strategies and individualized therapy. Background: Metabolic-associated fatty liver disease (MAFLD) has risen as one of the leading etiologies for hepatocellular carcinoma (HCC). Oncogenes have been suggested to be responsible for the high risk of MAFLD-related HCC. We analyzed the impact of the proto-oncogene c-MYC in the development of human and murine MAFLD and MAFLD-associated HCC. Methods: alb-myc(tg) mice were studied at baseline conditions and after administration of Western diet (WD) in comparison to WT littermates. c-MYC expression was analyzed in biopsies of patients with MAFLD and MAFLD-associated HCC by immunohistochemistry. Results: Mild obesity, spontaneous hyperlipidaemia, glucose intolerance and insulin resistance were characteristic of 36-week-old alb-myc(tg) mice. Middle-aged alb-myc(tg) exhibited liver steatosis and increased triglyceride content. Liver injury and inflammation were associated with elevated ALT, an upregulation of ER-stress response and increased ROS production, collagen deposition and compensatory proliferation. At 52 weeks, 20% of transgenic mice developed HCC. WD feeding exacerbated metabolic abnormalities, steatohepatitis, fibrogenesis and tumor prevalence. Therapeutic use of metformin partly attenuated the spontaneous MAFLD phenotype of alb-myc(tg) mice. Importantly, upregulation and nuclear localization of c-MYC were characteristic of patients with MAFLD and MAFLD-related HCC. Conclusions: A novel function of c-MYC in MAFLD progression was identified opening new avenues for preventative strategies.
C1 [Guo, Feifei; Estevez-Vazquez, Olga; Benede-Ubieto, Raquel; Zheng, Kang; Chen, Chaobo; Lamas-Paz, Arantza; Regueiro, Jose R.; Banares, Rafael; Cubero, Francisco Javier; Nevzorova, Yulia A.] Univ Complutense Madrid, Dept Immunol Ophthalmol & ENT, Sch Med, 12 Octubre Imas12 Hlth Res Inst, Madrid 28040, Spain.
   [Guo, Feifei] Nanjing Univ, Dept Obstet & Gynaecol, Sch Med, Drum Tower Hosp, Nanjing 210023, Peoples R China.
   [Benede-Ubieto, Raquel] Univ Complutense Madrid, Fac Biol, Dept Physiol Genet & Microbiol, Madrid 28040, Spain.
   [Maya-Miles, Douglas; Gallego-Duran, Rocio; Rojas, Angela; Ampuero, Javier; Romero-Gomez, Manuel] Univ Seville, Inst Biomed Seville IBiS, SeLiver Grp, Virgen Rocio Univ Hosp,CSIC, Seville 41013, Spain.
   [Maya-Miles, Douglas; Gallego-Duran, Rocio; Rojas, Angela; Ampuero, Javier; Romero-Gomez, Manuel] Virgen Rocio Univ Hosp, UCM Digest Dis, Seville 41013, Spain.
   [Maya-Miles, Douglas; Gallego-Duran, Rocio; Rojas, Angela; Ampuero, Javier; Romero-Gomez, Manuel; Simon, Jorge; Martinez-Chantar, Maria Luz; Vaquero, Javier; Banares, Rafael; Cubero, Francisco Javier; Nevzorova, Yulia A.] Ctr Invest Biomed Red Enfermedades Hepat & Digest, Madrid 28220, Spain.
   [Zheng, Kang; Sun, Jie] Southeast Univ, Zhongda Hosp, Sch Med, Dept Anesthesiol, Nanjing 210009, Peoples R China.
   [Romero-Gomez, Manuel] Univ Seville, Dept Med, Seville 41009, Spain.
   [Philip, Kaye; Egbuniwe, Isioma U.] Nottingham Univ Hosp NHS Trust, Queens Med Ctr Campus, Dept Pathol, Nottingham NG7 2UH, England.
   [Chen, Chaobo] Wuxi Xishan Peoples Hosp, Dept Gen Surg, Wuxi 214000, Peoples R China.
   [Chen, Chaobo] Nanjing Univ, Sch Med, Dept Hepat Biliary Pancreat Surg, Affiliated Drum Tower Hosp, Nanjing 210023, Peoples R China.
   [Simon, Jorge; Delgado, Teresa C.; Martinez-Chantar, Maria Luz] Ctr Cooperat Res Biosci CIC bioGUNE, Liver Dis Lab, Basque Res & Technol Alliance BRTA, Derio 48160, Spain.
   [Reissing, Johanna; Bruns, Tony; Woitok, Marius Maximilian; Liedtke, Christian; Trautwein, Christian; Nevzorova, Yulia A.] Univ Hosp RWTH Aachen, Dept Internal Med 3, D-52074 Aachen, Germany.
   [del Moral, Manuel Gomez] Univ Complutense, Dept Cell Biol, Sch Med, Madrid 28040, Spain.
   [Vaquero, Javier; Banares, Rafael] Univ Gregorio Maranon, Serv Aparato Digest, Hosp Gen, Madrid 28009, Spain.
   [Vaquero, Javier; Banares, Rafael; Cubero, Francisco Javier; Nevzorova, Yulia A.] Inst Invest Sanitaria Gregorio Maranon IiSGM, Madrid 28007, Spain.
C3 Complutense University of Madrid; Nanjing University; Complutense
   University of Madrid; Virgen del Rocio University Hospital; Consejo
   Superior de Investigaciones Cientificas (CSIC); University of Sevilla;
   CSIC-JA-USE - Instituto de Biomedicina de Sevilla (IBIS); Virgen del
   Rocio University Hospital; CIBER - Centro de Investigacion Biomedica en
   Red; CIBEREHD; Southeast University - China; University of Sevilla;
   Nottingham University Hospital NHS Trust; Nanjing University; CIC
   bioGUNE; RWTH Aachen University; RWTH Aachen University Hospital;
   Complutense University of Madrid; General University Gregorio Maranon
   Hospital
RP Nevzorova, YA (corresponding author), Univ Complutense Madrid, Dept Immunol Ophthalmol & ENT, Sch Med, 12 Octubre Imas12 Hlth Res Inst, Madrid 28040, Spain.; Nevzorova, YA (corresponding author), Ctr Invest Biomed Red Enfermedades Hepat & Digest, Madrid 28220, Spain.; Nevzorova, YA (corresponding author), Univ Hosp RWTH Aachen, Dept Internal Med 3, D-52074 Aachen, Germany.; Nevzorova, YA (corresponding author), Inst Invest Sanitaria Gregorio Maranon IiSGM, Madrid 28007, Spain.
EM feiguo@ucm.es; olgaeste@ucm.es; rabenede@ucm.es; dmaya-ibis@us.es;
   kzheng@ucm.es; rgallego-ibis@us.es; marojas-ibis@us.es;
   jampuero-ibis@us.es; mromerogomez@us.es; Philip.Kaye@nuh.nhs.uk;
   Isioma.Egbuniwe@nottingham.ac.uk; chaochen@ucm.es;
   jsimon.ciberehd@cicbiogune.es; tcardoso@cicbiogune.es;
   mlmartinez@cicbiogune.es; sunjie@seu.edu.cn; joreissing@ukaachen.de;
   tbruns@ukaachen.de; arlamas@ucm.es; mgomezm@med.ucm.es;
   M.Woitok@eclevar.com; j.vaquero@iisgm.com; regueiro@med.ucm.es;
   cliedtke@ukaachen.de; ctrautwein@ukaachen.de;
   Rafael.banares@salud.madrid.org; fcubero@ucm.es; yulianev@ucm.es
RI Liedtke, Christian/DTV-1874-2022; Gallego-Durán, Rocío/AAB-1791-2020;
   BENEDE, RAQUEL/ABG-1209-2020; Ampuero, Javier/AAI-2582-2019; Rojas,
   Ana/D-5777-2011; chen, chenbo/AEA-9700-2022; Gomez del Moral,
   Manuel/ABB-4917-2021; Lamas Paz, Arantza/HTO-8730-2023; Banares,
   Rafael/J-1460-2012; Simon, Jorge/E-8663-2019; Delgado,
   Teresa/ABF-9171-2020; Martinez Chantar, Maria Luz/F-5190-2011; Vaquero,
   Javier/C-5094-2018; Regueiro, Jose/B-5499-2014; Romero-Gomez,
   Manuel/L-8030-2014; chaobo, chen/X-6937-2019; Delgado,
   Teresa/L-1681-2014; Bruns, Tony/C-5720-2011
OI Gomez, Manuel/0000-0002-0642-8142; Martinez Chantar, Maria
   Luz/0000-0002-6446-9911; Nevzorova, Yulia A/0000-0003-1390-8002;
   Vaquero, Javier/0000-0001-8903-7288; Regueiro, Jose/0000-0001-8442-7762;
   Romero-Gomez, Manuel/0000-0001-8494-8947; chaobo,
   chen/0000-0001-5963-5295; Cubero, Francisco Javier/0000-0003-1499-650X;
   Benede-Ubieto, Raquel/0000-0003-1779-8832; Rojas,
   Angela/0000-0003-0853-4800; Simon, Jorge/0000-0003-0404-6244; Banares,
   Rafael/0000-0002-0412-8437; Lamas Paz, Arantza/0000-0001-5857-4320;
   Delgado, Teresa/0000-0001-9204-581X; Maya Miles,
   Douglas/0000-0002-0669-6526; Liedtke, Christian/0000-0003-4681-7887;
   Estevez Vazquez, Olga/0000-0002-7983-8521; Bruns,
   Tony/0000-0002-5576-6914
FU MINECO [Retos SAF2016-78711, SAF2017-87919-R, PID2020-117827RB-IOO,
   PID2020-117941RB-IOO, PID2020-117116RB-I00, EXOHEP-CM S2017/BMD3727,
   NanoLiver-CM Y2018/NMT-4949]; COST Action [CA17112, UCM-25/2019]; La
   Caixa Foundation Program [HR17-00601]; Asociacion Espanola Contra el
   Cancer [AECC PROYE20084 REGU]; German Research Foundation
   [403224013/A02, SFB1382, 403224013/B07]; Ramon y Cajal [RYC-2014-15242,
   RYC-2015-17438]; Beca FPI associated to MINECO [SAR2017-87919R];
   programa de Financiacion de Universidad Complutense de Madrid-Banco
   Santander [CT63/19]; CIBEREHD; Andalusian government (Proyectos
   Estrategicos-Fondos Feder) [PE-0451-2018]; Instituto de Salud Carlos III
   [PI16/01842, PI19/01404, PI19/00589]; AMMF [2018/117]
FX This work was supported by the MINECO Retos SAF2016-78711,
   SAF2017-87919-R, PID2020-117827RB-IOO, PID2020-117941RB-IOO,
   PID2020-117116RB-I00, EXOHEP-CM S2017/BMD3727, NanoLiver-CM
   Y2018/NMT-4949, AMMF 2018/117, COST Action CA17112 and UCM-25/2019, La
   Caixa Foundation ProgramHR17-00601; Asociacion Espanola Contra el Cancer
   (AECC PROYE20084 REGU); the German Research Foundation (SFB1382 Project
   ID 403224013/A02). FJC and YAN are Ramon y Cajal Researchers
   RYC-2014-15242 and RYC-2015-17438, respectively. FJC is a Gilead Liver
   Research Scholar. The research group belongs to the validated Research
   Groups Ref. 970935 "Liver Pathophysiology", 920631 "Lymphocyte
   immunobiology", 920361 "Inmunogenetica e inmunologia de las mucosas" and
   IBL-6 (imas12-associated). FG and KZ are Chinese Scholarship Council
   (CSC) fellows. O.E.-V is supported by Beca FPI associated to MINECO
   SAR2017-87919R and R.B.-U by programa de Financiacion de Universidad
   Complutense de Madrid-Banco Santander, CT63/19. DMM contract is
   supported by CIBEREHD. DMM, MRG, AR, JA and RG receive support from the
   Andalusian government (Proyectos Estrategicos-Fondos Feder PE-0451-2018)
   and from the Instituto de Salud Carlos III (PI16/01842, PI19/01404;
   PI19/00589). TB is supported by the German Research Foundation (SFB1382
   Project ID 403224013/B07).
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NR 42
TC 14
Z9 15
U1 0
U2 12
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6694
J9 CANCERS
JI Cancers
PD JAN
PY 2022
VL 14
IS 1
AR 192
DI 10.3390/cancers14010192
PG 19
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA ZE9VV
UT WOS:000759226000001
PM 35008356
OA Green Accepted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Grove, JI
   Lo, PCK
   Shrine, N
   Barwell, J
   Wain, LV
   Tobin, MD
   Salter, AM
   Borkar, AN
   Cuevas-Ocaña, S
   Bennett, N
   John, C
   Ntalla, I
   Jones, GE
   Neal, CP
   Thomas, MG
   Kuht, H
   Gupta, P
   Vemala, VM
   Grant, A
   Adewoye, AB
   Shenoy, KT
   Balakumaran, LK
   Hollox, EJ
   Hannan, NRF
   Aithal, GP
AF Grove, Jane I.
   Lo, Peggy C. K.
   Shrine, Nick
   Barwell, Julian
   V. Wain, Louise
   Tobin, Martin D.
   Salter, Andrew M.
   Borkar, Aditi N.
   Cuevas-Ocana, Sara
   Bennett, Neil
   John, Catherine
   Ntalla, Ioanna
   Jones, Gabriela E.
   Neal, Christopher P.
   Thomas, Mervyn G.
   Kuht, Helen
   Gupta, Pankaj
   Vemala, Vishwaraj M.
   Grant, Allister
   Adewoye, Adeolu B.
   Shenoy, Kotacherry T.
   Balakumaran, Leena K.
   Hollox, Edward J.
   Hannan, Nicholas R. F.
   Aithal, Guruprasad P.
TI Identification and characterisation of a rare MTTP variant
   underlying hereditary non-alcoholic fatty liver disease
SO JHEP REPORTS
LA English
DT Article
DE Microsomal triglyceride transfer protein; Abetalipoproteinaemia;
   hiPSC-derived hepatocytes; Lipoprotein ApoB
ID TRIGLYCERIDE TRANSFER PROTEIN; GENE-MUTATIONS; ABETALIPOPROTEINEMIA;
   MTTP; SECRETION; FIBROSIS; ABSENCE; RISK; VLDL
AB Background & Aims: Non-alcoholic fatty liver disease (NAFLD) is a complex trait with an estimated prevalence of 25% globally. We aimed to identify the genetic variant underlying a four-generation family with progressive NAFLD leading to cirrhosis, decompensation, and development of hepatocellular carcinoma in the absence of common risk factors such as obesity and type 2 diabetes.Methods: Exome sequencing and genome comparisons were used to identify the likely causal variant. We extensively characterised the clinical phenotype and post-prandial metabolic responses of family members with the identified novel variant in comparison with healthy non-carriers and wild-type patients with NAFLD. Variant-expressing hepatocyte-like cells (HLCs) were derived from human-induced pluripotent stem cells generated from homozygous donor skin fibroblasts and restored to wild-type using CRISPR-Cas9. The phenotype was assessed using imaging, targeted RNA analysis, and molecular expression arrays.Results: We identified a rare causal variant c.1691T>C p.I564T (rs745447480) in MTTP, encoding microsomal triglyceride transfer protein (MTP), associated with progressive NAFLD, unrelated to metabolic syndrome and without characteristic features of abetalipoproteinaemia. HLCs derived from a homozygote donor had significantly lower MTP activity and lower lipoprotein ApoB secretion than wild-type cells, while having similar levels of MTP mRNA and protein. Cytoplasmic triglyceride accumulation in HLCs triggered endoplasmic reticulum stress, secretion of pro-inflammatory mediators, and production of reactive oxygen species.Conclusions: We have identified and characterised a rare causal variant in MTTP, and homozygosity for MTTP p.I564T is associated with progressive NAFLD without any other manifestations of abetalipoproteinaemia. Our findings provide insights into mechanisms driving progressive NAFLD.Impact and Implications: A rare genetic variant in the gene MTTP has been identified as responsible for the development of severe non-alcoholic fatty liver disease in a four-generation family with no typical disease risk factors. A cell line culture created harbouring this variant gene was characterised to understand how this genetic variation leads to a defect in liver cells, which results in accumulation of fat and processes that promote disease. This is now a useful model for studying the disease pathways and to discover new ways to treat common types of fatty liver disease.(c) 2023 The Authors. Published by Elsevier B.V. on behalf of European Association for the Study of the Liver (EASL). This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
C1 [Grove, Jane I.; Aithal, Guruprasad P.] Nottingham Univ Hosp NHS Trust, Natl Inst Hlth Res NIHR Nottingham Biomed Res Ctr, Nottingham, England.
   [Grove, Jane I.; Aithal, Guruprasad P.] Univ Nottingham, Nottingham, England.
   [Grove, Jane I.; Aithal, Guruprasad P.] Univ Nottingham, Nottingham Digest Dis Ctr, Sch Med, Translat Med Sci, Nottingham, England.
   [Lo, Peggy C. K.; Cuevas-Ocana, Sara; Hannan, Nicholas R. F.] Univ Nottingham, Sch Med, Translat Med Sci, Nottingham, England.
   [Lo, Peggy C. K.; Cuevas-Ocana, Sara; Vemala, Vishwaraj M.; Hannan, Nicholas R. F.] Univ Nottingham, Biodiscovery Inst, Nottingham, England.
   [Shrine, Nick; V. Wain, Louise; Tobin, Martin D.; Adewoye, Adeolu B.] Univ Leicester, Dept Populat Hlth Sci, Genet Epidemiol Grp, Leicester, England.
   [Barwell, Julian; Ntalla, Ioanna; Jones, Gabriela E.] Univ Hosp Leicester NHS Trust, Clin Genet Dept, Leicester, England.
   [V. Wain, Louise; Tobin, Martin D.] Glen field Hosp, NIHR Leicester Resp Biomed Res Ctr, Leicester, England.
   [Salter, Andrew M.] Univ Nottingham, Sch Biosci, Nottingham, England.
   [Borkar, Aditi N.] Univ Nottingham, Sch Vet Med & Sci, Nottingham, England.
   [Neal, Christopher P.] Univ Leicester, Leicester Canc Res Ctr, Leicester, England.
   [Thomas, Mervyn G.; Kuht, Helen] Univ Leicester, Dept Neurosci Psychol & Behav, Ulverscroft Eye Unit, Leicester, England.
   [Gupta, Pankaj] Univ Hosp Leicester NHS Trust, Dept Chem Pathol & Metab Dis, Leicester, England.
   [Gupta, Pankaj] Univ Leicester, Dept Cardiovasc Sci, Leicester, England.
   [Vemala, Vishwaraj M.; Grant, Allister] Univ Hosp Leicester NHS Trust, Dept Gastroenterol, Leicester, England.
   [Adewoye, Adeolu B.; Hollox, Edward J.] Univ Leicester, Dept Genet & Genome Biol, Leicester, England.
   [Shenoy, Kotacherry T.; Balakumaran, Leena K.] Populat Hlth & Res Inst, Trivandrum, India.
   [Grant, Allister] Treliske Hosp, Truro, Cornwall, England.
   [Jones, Gabriela E.] Nottingham Univ Hosp NHS Trust, Dept Genet, Nottingham, England.
   [Adewoye, Adeolu B.] Nottingham Trent Univ, Sch Sci & Technol, Dept Biosci, Clifton Campus, Nottingham, England.
   [Aithal, Guruprasad P.] Univ Nottingham, Nottingham Digest Dis Ctr, Queens Med Ctr Campus, Nottingham NG7 2UH, England.
C3 Nottingham University Hospital NHS Trust; University of Nottingham;
   University of Nottingham; University of Nottingham; University of
   Nottingham; University of Leicester; University of Leicester; University
   Hospitals of Leicester NHS Trust; University of Nottingham; University
   of Nottingham; University of Leicester; University of Leicester;
   University Hospitals of Leicester NHS Trust; University of Leicester;
   University of Leicester; University of Leicester; University Hospitals
   of Leicester NHS Trust; University of Leicester; Royal Cornwall
   Hospital; Nottingham University Hospital NHS Trust; Nottingham Trent
   University; University of Nottingham
RP Aithal, GP (corresponding author), Univ Nottingham, Nottingham Digest Dis Ctr, Queens Med Ctr Campus, Nottingham NG7 2UH, England.
EM guru.aithal@nottingham.ac.uk
RI Salter, Andrew/JYQ-4173-2024; Cuevas Ocana, Sara/HDO-1094-2022
OI Wain, Louise/0000-0003-4951-1867; Barwell, Julian/0000-0003-0254-2308;
   Borkar, Aditi/0000-0001-9278-1438; John, Catherine/0000-0002-6057-2073;
   Aithal, Guruprasad/0000-0003-3924-4830; Tobin,
   Martin/0000-0002-3596-7874; Kondarappasserry Balakumaran,
   Leena/0000-0002-8885-4398; Grove, Jane/0000-0002-9950-7201; Cuevas
   Ocana, Sara/0000-0002-8326-5279
FU Medical Research Council (MRC) Nottingham Molecular Pathology Node
   [MR/N005953/1]; National Institute of Health Research (NIHR) Nottingham
   Digestive Diseases Biomedical Research Unit; Nottingham Biomedical
   Research Centre [BRC-1215-200 03]; NIHR Nottingham Biomedical Research
   Centre; Population Health and Research Institute; RoseTrees Trust and
   the Stoneygate Trust [M546]; Medical Research Council [MR/S009930/1];
   GSK/British Lung Foundation Chair in Respiratory Research [C17-1]; NIHR
   Leicester Biomedical Research Centre; Medical Research Council Clinical
   Research Training Fellowship [MR/P00167X/1]; University of Leicester;
   NIHR Leicester Respiratory Biomedical Research Centre; Wellcome [202849,
   G0902313]; Medical Research Council (MRC); BBRSC; NIHR; UK Space Agency;
   GSK; BREATHE - The Health Data Research Hub for Respiratory Health
   [WT202849/Z/16/Z]; MRC Grant Senior Clinical Fellowship [UKR_PC_19004];
   NIHR Senior Investigator Award; Academy of Finland (AKA) [202849]
   Funding Source: Academy of Finland (AKA)
FX This work was supported by the Medical Research Council (MRC) Nottingham
   Molecular Pathology Node (grant number MR/N005953/1), National Institute
   of Health Research (NIHR) Nottingham Digestive Diseases Biomedical
   Research Unit, and Nottingham Biomedical Research Centre (BRC-1215-200
   03). JIG and GPA are supported by NIHR Nottingham Biomedical Research
   Centre. KTS and LKB are supported by Population Health and Research
   Institute. All cell modelling was supported by the RoseTrees Trust and
   the Stoneygate Trust (M546). NRFH and SCO are supported by the Medical
   Research Council (MR/S009930/1). LVW holds a GSK/British Lung Foundation
   Chair in Respiratory Research (C17-1). The research was supported by the
   NIHR Leicester Biomedical Research Centre; CJ held a Medical Research
   Council Clinical Research Training Fellowship (MR/P00167X/1). EXCEED is
   supported by the University of Leicester, the NIHR Leicester Respiratory
   Biomedical Research Centre; by Wellcome (202849); and by Cohort Access
   fees from studies funded by the Medical Research Council (MRC), BBRSC,
   NIHR, the UK Space Agency, and GSK. This work is supported by BREATHE -
   The Health Data Research Hub for Respiratory Health (UKR_PC_19004) in
   partnership with SAIL Databank. The exome sequencing was funded by MRC
   Grant Senior Clinical Fellowship to MDT (G0902313), and we thank the
   high-throughput genomics group at the Wellcome Trust Centre for Human
   Genetics (funded by Wellcome Trust Grant 090532/Z/09/Z and MRC Hub Grant
   G090074791070) for the generation of the sequence data. MDT is supported
   by a Wellcome Trust Investigator Award (WT202849/Z/16/Z) and holds an
   NIHR Senior Investigator Award. The funders had no role in study design,
   data collection and analysis, decision to publish, or prepa-ration of
   the manuscript.
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NR 43
TC 10
Z9 11
U1 0
U2 4
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
EI 2589-5559
J9 JHEP REP
JI JHEP Rep.
PD AUG
PY 2023
VL 5
IS 8
AR 100764
DI 10.1016/j.jhepr.2023.100764
EA JUL 2023
PG 15
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA T5PP6
UT WOS:001078509700001
PM 37484212
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Parween, S
   Rihs, S
   Flück, CE
AF Parween, Shaheena
   Rihs, Silvia
   Fluck, Christa E.
TI Metformin inhibits the activation of melanocortin receptors 2 and 3
   in vitro: A possible mechanism for its anti-androgenic and weight
   balancing effects in vivo?
SO JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
LA English
DT Article; Proceedings Paper
CT 17th International Congress on Hormonal Steroids and Hormones and Cancer
CY NOV 26-29, 2018
CL Stellenbosch Inst Adv Study, Stellenbosch, SOUTH AFRICA
HO Stellenbosch Inst Adv Study
DE ACTH; Metformin; MC2R; MC3R; Antagonist; Steroidogenesis; 0S3 cells
ID TUMOR-CELLS; ADRENOCORTICOTROPIN; STEROIDOGENESIS; MUTATIONS; GROWTH;
   WOMEN
AB Metformin is recommended as one of the first-line drugs for the treatment of type 2 diabetes and the metabolic syndrome. In addition to its insulin sensitizing effects, it has been shown to attenuate androgen excess in women with polycystic ovary syndrome (PCOS) or congenital adrenal hyperplasia (CAH), as well as to ameliorate obesity. The mechanisms of metformin action seem manifold. Preclinical studies suggest that it inhibits the cellular stress response at the level of the mitochondrial OXPHOS system and through AMPK dependent and independent mechanisms. Recent studies have shown that metformin decreases ACTH secretion from pituitary and reduces ACTH-stimulated adrenal secretion. In this study we investigated its specific effect through the melanocortin receptor 2 (MC2R) on signaling targeting adrenal steroidogenesis. To assess this effect, we used mouse adrenal 0S3 cells, which do not express the MC2R. Cells were transfected with the MC2R and stimulated by ACTH. Downstream cyclic AMP production was then assessed by a co-transfected cAMP-responsive vector producing luciferase that was measured by a dual luciferase assay. The amount of luciferase produced in this assay corresponds to the amount of receptor activation with varying amount of ACTH. The effect of metformin was then tested in this system. We found a significant inhibition of ACTH induced MC2R activation and signaling with 10 mM metformin. The ACTH concentration response curve (CRC) was half-log shifted and a similar to 30 % reduction in maximum receptor response (Rmax) to ACTH in presence of metformin was observed. This effect was dose dependent with an IC50, of 4.2 mM. qRT-PCR analyses showed that metformin decreased ACTH induced MC2R expression. Metformin did not affect cell viability and basal cAMP levels. We also tested the effect of metformin on homologous melanocortin receptors (MCRs). No significant effect was found on MC1R and MC4R activity. However, a log shift of EC50 of ACTH stimulation on MC3R was observed with metformin treatment. Metformin also inhibited melanocortin stimulating hormone (alpha MSH) induced MC3R activity. In conclusion, we show that metformin acts on MC2R and MC3R signaling directly. The role of MC2R for steroidogenesis is well established. MC3R is involved in energy balance and seems to act as a rheostat when the metabolism is challenged. Our study may explain how metformin helps in weight loss and attenuates the excess response to ACTH in androgen excess disorders such as PCOS and CAH.
C1 [Parween, Shaheena; Rihs, Silvia; Fluck, Christa E.] Univ Childrens Hosp Bern, Dept Pediat, Pediat Endocrinol Diabetol & Metab, CH-3010 Bern, Switzerland.
   [Parween, Shaheena; Rihs, Silvia; Fluck, Christa E.] Univ Bern, Dept Biomed Res, CH-3010 Bern, Switzerland.
C3 University of Bern; University Hospital of Bern; University of Bern
RP Flück, CE (corresponding author), Univ Childrens Hosp, Pediat Endocrinol & Diabetol, Freiburgstr 15-C845, CH-3010 Bern, Switzerland.
EM christa.flueck@dbmr.unibe.ch
OI Parween, Shaheena/0000-0002-2013-8037
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NR 47
TC 9
Z9 11
U1 0
U2 4
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0960-0760
J9 J STEROID BIOCHEM
JI J. Steroid Biochem. Mol. Biol.
PD JUN
PY 2020
VL 200
AR 105684
DI 10.1016/j.jsbmb.2020.105684
PG 7
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA LU3PO
UT WOS:000537671500028
PM 32360359
DA 2025-06-11
ER

PT J
AU Logstrup, BB
   Hofsten, DE
   Christophersen, TB
   Moller, JE
   Botker, HE
   Pellikka, PA
   Egstrup, K
AF Logstrup, Brian B.
   Hofsten, Dan E.
   Christophersen, Thomas B.
   Moller, Jacob E.
   Botker, Hans E.
   Pellikka, Patricia A.
   Egstrup, Kenneth
TI Influence of Abnormal Glucose Metabolism on Coronary Microvascular
   Function After a Recent Myocardial Infarction
SO JACC-CARDIOVASCULAR IMAGING
LA English
DT Article
DE coronary flow reserve; transthoracic echocardiography; acute myocardial
   infarction; dysglycemia; impaired glucose tolerance; oral glucose
   tolerance test
ID TRANSTHORACIC DOPPLER-ECHOCARDIOGRAPHY; VENTRICULAR SYSTOLIC FUNCTION;
   2ND-HARMONIC ECHO-DOPPLER; SOCIETY-OF-CARDIOLOGY; LONG-TERM MORTALITY;
   FLOW RESERVE; DIABETES-MELLITUS; STRESS ECHOCARDIOGRAPHY; INTRACORONARY
   DOPPLER; AMERICAN-SOCIETY
AB OBJECTIVES This study sought to assess the association between abnormal glucose metabolism and abnormal coronary flow reserve (CFR) in patients with a recent acute myocardial infarction (AMI).
   BACKGROUND Mortality and morbidity after AMI is high among patients with abnormal glucose metabolism, which may be related to abnormal microcirculation.
   METHODS We studied 183 patients with a first AMI. In 161 patients with no history of diabetes mellitus (DM), an oral glucose tolerance test was performed, and patients were categorized according to World Health Organization criteria for whole blood glucose into 3 groups. After coronary angiography and revascularization, a comprehensive transthoracic echocardiogram and noninvasive assessment of CFR was performed in the distal part of left descending artery, as an indicator of microvascular function. Adenosine was administered by intravenous infusion (140 mu g/kg/min) to obtain the hyperemic flow profiles. The CFR was defined as the ratio of hyperemic to baseline peak diastolic coronary flow velocities.
   RESULTS Median CFR was 1.9 (interquartile range [IQR] 1.4 to 2.4], and 109 (60%) patients had a CFR <= 2. The lowest CFR was seen in patients with a history of DM (1.4 [IQR 1.4 to 1.7], n = 22) and in patients with newly diagnosed DM (1.6 [IQR 1.3 to 2], n = 39), whereas CFR did not differ in patients with abnormal glucose tolerance (2.1 [IQR 1.4 to 2.6], n = 58) and in patients with normal glucose tolerance (2.2 [IQR 1.7 to 2.6], n = 62). In a stepwise logistic regression model adjusting for age, sex, site and size of AMI, heart rate, risk factors of the metabolic syndrome, degree of angiographic evidence of coronary artery disease, and medical therapy, newly diagnosed DM (odds ratio: 3.0) and a history of DM (odds ratio: 9.9) remained significant predictors of CFR <2, whereas impaired glucose tolerance was not.
   CONCLUSIONS CFR is decreased in patients with known or newly diagnosed DM even after adjustment of possible confounders, whereas CFR in patients with impaired glucose tolerance seems less affected. (Coronary Flow Reserve and Glucometabolic State [CFRGS]; NCT00845468) (J Am Coll Cardiol Img 2009; 2: 1159-66) (C) 2009 by the American College of Cardiology Foundation
C1 [Logstrup, Brian B.; Hofsten, Dan E.; Christophersen, Thomas B.; Egstrup, Kenneth] Funen Hosp Svendborg, Dept Med Res, DK-5700 Svendborg, Denmark.
   [Moller, Jacob E.] Rigshosp, Copenhagen Univ Hosp, Dept Cardiol, DK-2100 Copenhagen, Denmark.
   [Botker, Hans E.] Aarhus Univ Hosp Skejby, Dept Cardiol, Aarhus, Denmark.
   [Pellikka, Patricia A.] Mayo Clin, Div Cardiovasc Dis, Rochester, MN USA.
C3 University of Copenhagen; Copenhagen University Hospital;
   Rigshospitalet; Aarhus University; Mayo Clinic
RP Logstrup, BB (corresponding author), Funen Hosp Svendborg, Dept Med Res, DK-5700 Svendborg, Denmark.
EM bbl@dadlnet.dk
RI Pellikka, Patricia/N-5387-2014; Bøtker, Hans Erik/AFB-5630-2022;
   Hoefsten, Dan/MHQ-1259-2025
OI Pellikka, Patricia/0000-0001-6800-3521; Botker, Hans
   Erik/0000-0001-6358-8962; Moller, Jacob Eifer/0000-0003-2873-5845
FU Danish Heart Foundation [07-4-B368-A1392-22379]
FX The Danish Heart Foundation supported the Research fellowship of Dr.
   Logstrup (grant no. 07-4-B368-A1392-22379).
CR Abbate A, 2004, CIRCULATION, V110, P46, DOI 10.1161/01.CIR.0000133316.92316.81
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NR 26
TC 22
Z9 25
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1936-878X
EI 1876-7591
J9 JACC-CARDIOVASC IMAG
JI JACC-Cardiovasc. Imag.
PD OCT
PY 2009
VL 2
IS 10
BP 1159
EP 1166
DI 10.1016/j.jcmg.2009.06.012
PG 8
WC Cardiac & Cardiovascular Systems; Radiology, Nuclear Medicine & Medical
   Imaging
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Radiology, Nuclear Medicine &
   Medical Imaging
GA 725OS
UT WOS:000287655700003
PM 19833304
OA Bronze
DA 2025-06-11
ER

PT J
AU Graelmann, FJ
   Gondorf, F
   Majlesain, Y
   Niemann, B
   Klepac, K
   Gosejacob, D
   Gottschalk, M
   Mayer, M
   Iriady, I
   Hatzfeld, P
   Lindenberg, SK
   Wunderling, K
   Thiele, C
   Abdullah, Z
   He, W
   Hiller, K
   Händler, K
   Beyer, MD
   Ulas, T
   Pfeifer, A
   Esser, C
   Weighardt, H
   Förster, I
   Reverte-Salisa, L
AF Graelmann, Frederike J.
   Gondorf, Fabian
   Majlesain, Yasmin
   Niemann, Birte
   Klepac, Katarina
   Gosejacob, Dominic
   Gottschalk, Marlene
   Mayer, Michelle
   Iriady, Irina
   Hatzfeld, Philip
   Lindenberg, Sophie K.
   Wunderling, Klaus
   Thiele, Christoph
   Abdullah, Zeinab
   He, Wei
   Hiller, Karsten
   Haendler, Kristian
   Beyer, Marc D.
   Ulas, Thomas
   Pfeifer, Alexander
   Esser, Charlotte
   Weighardt, Heike
   Foerster, Irmgard
   Reverte-Salisa, Laia
TI Differential cell type-specific function of the aryl hydrocarbon
   receptor and its repressor in diet-induced obesity and fibrosis
SO MOLECULAR METABOLISM
LA English
DT Article
DE Metabolic dysfunction; Indole-3-carbinol; Collagen deposition; Energy
   expenditure; Macrophage metabolism; Hepatic steatosis
ID ADIPOSE-TISSUE; LIVER FIBROSIS; AH RECEPTOR; DIOXIN RECEPTOR; FATTY
   LIVER; MACROPHAGES; MICE; ACTIVATION; DEFICIENCY; TCDD
AB Objective: The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor regulating xenobiotic responses as well as physiological metabolism. Dietary AhR ligands activate the AhR signaling axis, whereas AhR activation is negatively regulated by the AhR repressor (AhRR). While AhR-de ficient mice are known to be resistant to diet-induced obesity (DIO), the in fluence of the AhRR on DIO has not been assessed so far. Methods: In this study, we analyzed AhRR - / - mice and mice with a conditional deletion of either AhRR or AhR in myeloid cells under conditions of DIO and after supplementation of dietary AhR ligands. Moreover, macrophage metabolism was assessed using Seahorse Mito Stress Test and ROS assays as well as transcriptomic analysis. Results: We demonstrate that global AhRR de ficiency leads to a robust, but not as profound protection from DIO and hepatosteatosis as AhR de ficiency. Under conditions of DIO, AhRR - / - mice did not accumulate TCA cycle intermediates in the circulation in contrast to wild -type (WT) mice, indicating protection from metabolic dysfunction. This effect could be mimicked by dietary supplementation of AhR ligands in WT mice. Because of the predominant expression of the AhRR in myeloid cells, AhRR-de ficient macrophages were analyzed for changes in metabolism and showed major metabolic alterations regarding oxidative phosphorylation and mitochondrial activity. Unbiased transcriptomic analysis revealed increased expression of genes involved in de novo lipogenesis and mitochondrial biogenesis. Mice with a genetic de ficiency of the AhRR in myeloid cells did not show alterations in weight gain after high fat diet (HFD) but demonstrated ameliorated liver damage compared to control mice. Further, deficiency of the AhR in myeloid cells also did not affect weight gain but led to enhanced liver damage and adipose tissue fibrosis compared to controls. Conclusions: AhRR-deficient mice are resistant to diet-induced metabolic syndrome. Although conditional ablation of either the AhR or AhRR in myeloid cells did not recapitulate the phenotype of the global knockout, our findings suggest that enhanced AhR signaling in myeloid cells de ficient for AhRR protects from diet-induced liver damage and fibrosis, whereas myeloid cell-specific AhR de ficiency is detrimental. (c) 2024 The Author(s). Published by Elsevier GmbH. This is an open access article under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).
C1 [Graelmann, Frederike J.; Gondorf, Fabian; Majlesain, Yasmin; Gottschalk, Marlene; Mayer, Michelle; Iriady, Irina; Hatzfeld, Philip; Lindenberg, Sophie K.; Weighardt, Heike; Foerster, Irmgard; Reverte-Salisa, Laia] Univ Bonn, Life & Med Sci LIMES Inst, Immunol & Environm, Bonn, Germany.
   [Niemann, Birte; Klepac, Katarina; Gosejacob, Dominic; Pfeifer, Alexander] Univ Bonn, Univ Hosp Bonn, Inst Pharmacol & Toxicol, Bonn, Germany.
   [Wunderling, Klaus; Thiele, Christoph] Univ Bonn, Life & Med Sci LIMES Inst, Biochem & Cell Biol Lipids, Bonn, Germany.
   [Abdullah, Zeinab] Univ Bonn, Univ Hosp Bonn, Inst Mol Med & Expt Immunol, Bonn, Germany.
   [He, Wei; Hiller, Karsten] Tech Univ Carolo Wilhelmina Braunschweig, Braunschweig Integrated Ctr Syst Biol BRICS, Braunschweig, Germany.
   [Haendler, Kristian; Beyer, Marc D.; Ulas, Thomas] German Ctr Neurodegenerat Dis, PRECISE Platform Single cell Genom & Epigen, Bonn, Germany.
   [Haendler, Kristian; Beyer, Marc D.; Ulas, Thomas] Univ Bonn, Bonn, Germany.
   [Haendler, Kristian; Beyer, Marc D.; Ulas, Thomas] West German Genome Ctr, Bonn, Germany.
   [Haendler, Kristian; Ulas, Thomas] Univ Bonn, Life & Med Sci LIMES Inst, Genom & Immunoregulat, Bonn, Germany.
   [Haendler, Kristian] Univ Lubeck, Inst Human Genet, Univ Klinikum Schleswig Holstein, D-23562 Lubeck, Germany.
   [Haendler, Kristian] Univ Kiel, D-23562 Lubeck, Germany.
   [Beyer, Marc D.] German Ctr Neurodegenerat Dis, Immunogen & Neurodegenerat, Bonn, Germany.
   [Esser, Charlotte; Weighardt, Heike] IUF Leibniz Res Inst Environm Med gGmbH, Dusseldorf, Germany.
C3 University of Bonn; University of Bonn; University of Bonn; University
   of Bonn; Braunschweig University of Technology; Helmholtz Association;
   German Center for Neurodegenerative Diseases (DZNE); University of Bonn;
   University of Bonn; University of Lubeck; University of Kiel; Schleswig
   Holstein University Hospital; University of Kiel; Helmholtz Association;
   German Center for Neurodegenerative Diseases (DZNE); Leibniz
   Association; Leibniz Institut fur Umweltmedizinische Forschung (IUF)
RP Förster, I; Reverte-Salisa, L (corresponding author), LIMES Inst, Immunol & Environm, Carl Troll Str 31, D-53115 Bonn, Germany.
EM laia@uni-bonn.de
RI Beyer, Marc/GQP-5814-2022; Abdullah, Zeinab/HII-5346-2022
OI Gottschalk, Marlene/0000-0003-1881-438X; He, Wei/0000-0003-2377-7456;
   Reverte-Salisa, Laia/0000-0002-9216-682X; Lindenberg,
   Sophie/0009-0000-6590-8771
FU Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) [SFB
   1454, 432325352, EXC 1023, 194445620, EXC 2151, 390873048, WE 2625/4-1,
   TRR 333/1-450149205]; University of Bonn through an Argelander grant;
   Jrgen Manchot Foundation
FX We are grateful to Babette Martiensen for technical help. This work was
   supported by the Deutsche Forschungsgemeinschaft (DFG, German Research
   Foundation) through SFB 1454 (Project No. 432325352) (to I.F., K.H.,
   M.D.B., A. P. and C.T.) , EXC 1023 (Project No. 194445620) (to I.F.) ,
   EXC 2151 (Project No. 390873048) (to I.F.) , WE 2625/4-1 (to H.W.) , and
   TRR 333/1-450149205 (to I.F. and A.P.); the University of Bonn through
   an Argelander grant to F.G., as well as the Juergen Manchot Foundation
   (to I.F. and H.W.) .
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NR 109
TC 3
Z9 3
U1 3
U2 6
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2212-8778
J9 MOL METAB
JI Mol. Metab.
PD JUL
PY 2024
VL 85
AR 101963
DI 10.1016/j.molmet.2024.101963
EA JUN 2024
PG 14
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA WR5V3
UT WOS:001256622200001
PM 38821174
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Alblihd, MA
   Alsharif, KF
   Hamad, AA
   Ali, FAZ
   Hussein, MT
   Alhegaili, AS
   Hassan, MA
   Al-Amer, OM
   Albezrah, NKA
   Almalki, AA
   Albarakati, AJA
   Alghamdi, KS
   Alzahrani, KJ
   Albrakati, A
   Alrubai, EH
   ElAshmouny, N
   Elmahallawy, EK
AF Alblihd, Mohamed A.
   Alsharif, Khalaf F.
   Hamad, Asmaa A.
   Ali, Fatma Abo Zakaib
   Hussein, Manal T.
   Alhegaili, Alaa S.
   Hassan, Mohamed Ahmed
   Al-Amer, Osama M.
   Albezrah, Nisreen Khalid Aref
   Almalki, Abdulraheem Ali
   Albarakati, Alaa Jameel A.
   Alghamdi, Khalid S.
   Alzahrani, Khalid J.
   Albrakati, Ashraf
   Alrubai, Elham Hamed
   ElAshmouny, Naira
   Elmahallawy, Ehab Kotb
TI Okra [Abelmoschus esculentus (L.) Moench] improved blood glucose
   and restored histopathological alterations in splenic tissues in a rat
   model with streptozotocin-induced type 1 diabetes through
   CD8<SUP>+</SUP> T cells and NF-kβ expression
SO FRONTIERS IN VETERINARY SCIENCE
LA English
DT Article
DE diabetes; okra; white pulp; lymphocyte; hemosiderosis; NF-k beta
ID OXIDATIVE STRESS; KAPPA-B; FERULIC ACID; SPLEEN; INFLAMMATION;
   MECHANISMS; QUERCETIN; EXTRACTS; MICE; POLYSACCHARIDES
AB Diabetes mellitus is a complex metabolic syndrome that involves dysfunction of spleen and other lymphoid organs. Medicinal plants, including okra (Abelmoschus esculentus (L.) Moench), were used widely for diabetes treatment. Scarce data are available about the potential anti-diabetic effects of okra, the histopathological alterations in splenic tissues and the mechanistic pathways underlying this association. The current research investigated the effects of okra pod extract on the biochemical parameters and expression of CD8(+) T cells and nuclear factor kappa (NF-k) B and releasing proinflammatory cytokines in spleen in streptozotocin (STZ)-induced diabetic rat models. A total of 50 mature male Wister albino rats were divided into five isolated groups; the first served as control (untreated) animals, the second (DM group) diabetes induced by STZ (at a dose of 45 mg/kg body weight, administered intraperitoneally), the third group (DM + Insulin): diabetic rats administered insulin subcutaneously (10 units/kg bw/day) daily for 4 weeks, the fourth group was administrated 400 mg/kg okra extract daily for 4 weeks, and diabetic induced rats in the fifth group were administrated 400 mg/kg okra extract daily for 4 weeks. The 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging activity in Abelmoschus esculentus (L.) Moench was studied, and the content of phenolic compounds in okra pods was estimated using high-performance liquid chromatography. Diabetes induction led to decreased body weight, increased blood glucose levels. Capsular thickness was significantly increased, white pulp was widely dispersed, and mature lymphocytes in the periphery were also drastically decreased, with thick follicular arteries, necrosis, and depletion of lymphocytes in the germinal center. Red pulp revealed severe congestion and degenerative changes, deposition of hemosiderin granules and lymphocytic depletion. In addition, collagen fiber deposition was increased also in this group. The induction of diabetes exaggerated NF-k beta expression and mediated downregulation of the expression of CD8(+) T cells in spleen tissue. Interestingly, oral administration of okra extracts post diabetes induction could mitigate and reverse such adverse effects. Altogether, our study points out the potential benefits of okra in improving blood glucose levels and restoring histopathological alterations in splenic tissues through CD8(+) T cells and NF-k beta expression in a diabetic rat model.
C1 [Alblihd, Mohamed A.] Taif Univ, Coll Med, Dept Med Microbiol & Immunol, Taif, Saudi Arabia.
   [Alblihd, Mohamed A.; Alsharif, Khalaf F.; Hamad, Asmaa A.] Taif Univ, High Altitude Res Ctr, Taif, Saudi Arabia.
   [Alsharif, Khalaf F.] Taif Univ, Coll Appl Med Sci, Dept Clin Labs Sci, Taif, Saudi Arabia.
   [Hamad, Asmaa A.] Taif Univ, Coll Sci, Dept Biol, Taif, Saudi Arabia.
   [Ali, Fatma Abo Zakaib] Sohag Univ, Fac Vet Med, Dept Pathol & Clin Pathol, Sohag, Egypt.
   [Hussein, Manal T.] Assiut Univ, Fac Vet Med, Dept Cell & Tissues, Asyut, Egypt.
   [Alhegaili, Alaa S.] Prince Sattam bin Abdulaziz Univ, Coll Appl Med Sci, Dept Med Lab, Alkharj, Saudi Arabia.
   [Hassan, Mohamed Ahmed] Al Azhar Univ, Fac Agr, Assiut Branch, Food Sci & Technol Dept, Asyut, Egypt.
   [Al-Amer, Osama M.] Univ Tabuk, Fac Appl Med Sci, Dept Med Lab Technol, Tabuk, Saudi Arabia.
   [Al-Amer, Osama M.] Univ Tabuk, Fac Sci, Genome & Biotechnol Unit, Tabuk, Saudi Arabia.
   [Albezrah, Nisreen Khalid Aref] Taif Univ, Coll Med, Dept Ophthalmol, Taif, Saudi Arabia.
   [Almalki, Abdulraheem Ali] Taif Univ, Coll Appl Med Sci, Dept Clin Lab Sci, Taif, Saudi Arabia.
   [Albarakati, Alaa Jameel A.] Umm Al Qura Univ, Coll Med, Surg Dept, Al Qunfudah Branch, Mecca, Saudi Arabia.
   [Alghamdi, Khalid S.] Minist Hlth Saudi Arabia, Forens Poison Serv Adm, Forens Med Serv Ctr Taif, Taif, Saudi Arabia.
   [Alzahrani, Khalid J.] Taif Univ, Coll Appl Med Sci, Dept Clin Lab Sci, Taif, Saudi Arabia.
   [Albrakati, Ashraf] Taif Univ, Coll Med, Dept Human Anat, Taif, Saudi Arabia.
   [Alrubai, Elham Hamed] Secur Forces Hosp, Internal Med Dept, Riyadh, Saudi Arabia.
   [ElAshmouny, Naira] Kafrelsheikh Univ, Fac Med, Dept Histol & Cell Biol, Kafr Al Sheikh, Egypt.
   [Elmahallawy, Ehab Kotb] Univ Cordoba, Fac Vet, Dept Sanidad Anim, Grp Invest San Anim & Zoonosis GISAZ, Cordoba, Spain.
   [Elmahallawy, Ehab Kotb] Sohag Univ, Fac Vet Med, Dept Zoonoses, Sohag, Egypt.
C3 Taif University; Taif University; Taif University; Taif University;
   Egyptian Knowledge Bank (EKB); Sohag University; Egyptian Knowledge Bank
   (EKB); Assiut University; Prince Sattam Bin Abdulaziz University;
   Egyptian Knowledge Bank (EKB); Al Azhar University; University of Tabuk;
   University of Tabuk; Taif University; Taif University; Umm Al-Qura
   University; Taif University; Taif University; Security Forces Hospital -
   Saudi Arabia; Egyptian Knowledge Bank (EKB); Kafrelsheikh University;
   Universidad de Cordoba; Egyptian Knowledge Bank (EKB); Sohag University
RP Alsharif, KF (corresponding author), Taif Univ, High Altitude Res Ctr, Taif, Saudi Arabia.; Alsharif, KF (corresponding author), Taif Univ, Coll Appl Med Sci, Dept Clin Labs Sci, Taif, Saudi Arabia.; Elmahallawy, EK (corresponding author), Univ Cordoba, Fac Vet, Dept Sanidad Anim, Grp Invest San Anim & Zoonosis GISAZ, Cordoba, Spain.; Elmahallawy, EK (corresponding author), Sohag Univ, Fac Vet Med, Dept Zoonoses, Sohag, Egypt.
EM alsharif@tu.edu.sa; eehaa@unileon.es
RI Albarakati, Alaa Jameel A/HKV-7289-2023; Al-Amer, Osama/ABB-5368-2020;
   Almalki, Abdulraheem/KYP-1626-2024; Alhegaili, Alaa/JEF-8854-2023;
   Hussein, Manal/ABG-9411-2020; Alzahrani, Khalid/AAJ-4886-2021; Ali,
   Fatma/ADS-4464-2022; Hassan, Mohamed/HMW-0806-2023; Kotb Elmahallawy,
   Ehab/N-1060-2018; Albrakati, Ashraf/AHA-0672-2022
OI Kotb Elmahallawy, Ehab/0000-0003-4484-3678; Albrakati,
   Ashraf/0000-0002-4116-7865; Alhegaili, Alaa/0000-0002-0984-167X; Ahmed
   Hassan, Mohamed/0000-0002-9483-9872; Albarakati, Alaa Jameel
   A./0000-0001-8211-9133
FU Taif University through the Research Group [1-442-48]
FX The author(s) declare financial support was received for the research,
   authorship, and/or publication of this article. This study was financed
   by Taif University through the Research Group; project number: 1-442-48.
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NR 93
TC 4
Z9 4
U1 1
U2 7
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 2297-1769
J9 FRONT VET SCI
JI Front. Vet. Sci.
PD NOV 16
PY 2023
VL 10
AR 1268968
DI 10.3389/fvets.2023.1268968
PG 18
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA Z4JH9
UT WOS:001111749600001
PM 38046568
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Le, MT
   Lanaspa, MA
   Cicerchi, CM
   Rana, J
   Scholten, JD
   Hunter, BL
   Rivard, CJ
   Randolph, RK
   Johnson, RJ
AF Le, MyPhuong T.
   Lanaspa, Miguel A.
   Cicerchi, Christina M.
   Rana, Jatinder
   Scholten, Jeffrey D.
   Hunter, Brandi L.
   Rivard, Christopher J.
   Randolph, R. Keith
   Johnson, Richard J.
TI Bioactivity-Guided Identification of Botanical Inhibitors of
   Ketohexokinase
SO PLOS ONE
LA English
DT Article
ID SUGAR-SWEETENED BEVERAGES; SOFT DRINK CONSUMPTION; CHOW-FED RATS;
   METABOLIC SYNDROME; INSULIN-RESISTANCE; CIRCULATING CONCENTRATIONS;
   OVERWEIGHT/OBESE HUMANS; DIABETES-MELLITUS; FRUCTOSE INFUSION;
   KIDNEY-DISEASE
AB Objective
   In developed countries with westernized diets, the excessive consumption of added sugar in beverages and highly refined and processed foods is associated with increased risk for obesity, diabetes, and cardiovascular diseases. As a major constituent of added sugars, fructose has been shown to cause a variety of adverse metabolic effects, such as impaired insulin sensitivity, hypertriglyceridemia, and oxidative stress. Recent studies have shown that ketohexokinase isoform C is the key enzyme responsible in fructose metabolism that drive's fructose's adverse effects. The objective of this study was to identify botanical ingredients with potential for inhibitory activity against ketohexokinase-C and fructose-induced metabolic effects by using a series of in vitro model systems.
   Methods
   Extracts from 406 botanicals and 1200 purified phytochemicals were screened (initial concentration of 50 mu g/mL and 50 mu M, respectively) for their inhibitory activity using a cell free, recombinant human ketohexokinase-C assay. Dose response evaluations were conducted on botanical extracts and phytochemicals that inhibited ketohexokinase-C by > 30% and > 40%, respectively. Two different extract lots of the top botanical candidates were further evaluated in lysates of HepG2 cells overexpressing ketohexokinase-C for inhibition of fructose-induced ATP depletion. In addition, extracts were evaluated in intact Hep G2 cells for inhibition of fructose-induced elevation of triglyceride and uric acid production.
   Results
   Among the botanical extracts, phloretin (Malus domestica) extracts were the most potent (IC50: 8.9-9.2 mu g/mL) followed by extracts of Angelica archangelica (IC50: 22.6 mu g/mL-57.3 mu g/mL). Among the purified phytochemicals, methoxy-isobavachalcone (Psoralea corylifolia, IC50 = 0.2 mu M) exhibited the highest potency against ketohexokinase isoform C activity followed by osthole (Angelica archangelica, IC50 = 0.7 mu M), cratoxyarborenone E (Cratoxylum prunifolium, IC50 = 1.0 mu M), and alpha-/gamma-mangostin (Cratoxylum prunifolium, IC50 = 1.5 mu M). Extracts of Angelica archangelica, Garcinia mangostana, Petroselinum crispum, and Scutellaria baicalensis exhibited ketohexokinase inhibitory activity and blocked fructose-induced ATP depletion and fructose-induced elevation in triglyerides and uric acid.
   Conclusions
   Angelica archangelica, Garcinia mangostana, Petroselinum crispum, and Scutellaria baicalensis were the top four botanical candidiates identified with inhibitory activity against ketohexokinase-C. Future studies are needed to show proof of mechanism and the efficacy of these botanical extracts in humans to blunt the negative metabolic effects of fructose-containing added sugars.
C1 [Le, MyPhuong T.; Lanaspa, Miguel A.; Cicerchi, Christina M.; Hunter, Brandi L.; Rivard, Christopher J.; Johnson, Richard J.] Univ Colorado, Dept Med, Div Renal Dis & Hypertens, Anschutz Med Campus, Aurora, CO USA.
   [Rana, Jatinder; Scholten, Jeffrey D.; Randolph, R. Keith] Amway Res & Dev, Ada, MI USA.
C3 University of Colorado System; University of Colorado Anschutz Medical
   Campus
RP Le, MT (corresponding author), Univ Colorado, Dept Med, Div Renal Dis & Hypertens, Anschutz Med Campus, Aurora, CO USA.
EM myphuong.le@ucdenver.edu
RI Lanaspa, Miguel/AAO-4971-2020
OI Le, MyPhuong/0000-0002-1136-3419
FU RJJ; Amway Research and Development
FX The study was supported by funding from startup funds of RJJ and
   research funding from Amway Research and Development that was received
   by RJJ.
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NR 55
TC 16
Z9 20
U1 0
U2 13
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JUN 20
PY 2016
VL 11
IS 6
AR e0157458
DI 10.1371/journal.pone.0157458
PG 17
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA DP0WR
UT WOS:000378212000017
PM 27322374
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Olszanecka-Glinianowicz, M
   Chudek, J
AF Olszanecka-Glinianowicz, Magdalena
   Chudek, Jerzy
TI The level of health education in the Polish population
SO ANNALS OF AGRICULTURAL AND ENVIRONMENTAL MEDICINE
LA English
DT Article
DE lifestyle; education; obesity; type-2 diabetes; cardiovascular diseases
ID LIFE-STYLE INTERVENTION; SCIENTIFIC STATEMENT; METABOLIC SYNDROME; CARE
   COSTS; OBESITY; RISK; UNIVERSITY; STUDENTS; DISEASE; WEIGHT
AB Background: The study assessed factors influencing awareness of Poles concerning lifestyle factors that affect development of obesity, type 2 diabetes and cardiovascular diseases (CVD).
   Methods: A questionnaire survey covering awareness of lifestyle factors performed by general practitioners in 37,557 unselected patients.
   Results: 96.1% of respondents believed that lifestyle has an impact on the occurrence of CVDs, especially: tobacco smoking (91.4%), excessive intake of fat (81.3%), alcohol (67.5%), salt (64.9%), and stress (64.9%). 79.0% respondents believed the smoking cessation, 77.5% weight loss and 66.8% healthy diet are most important to prevent diseases. Additionally, the belief in the need for an early weight reduction decreased with increasing BMI (82.9% with normal weight vs. 77.5% overweight and 70.4% obese).The most common source of health education was a physician (75.8%), the mass media, such as television and the press (62.0% and 64.8%, respectively), less often were educational materials (37.8%) and books (20.3 %), the Internet (3.8%) and radio (0.8%). Younger respondents presented a higher level of awareness about all analysed aspects of healthy lifestyle. The multiple regression analysis revealed that low education level and rural residence are the most important factors decreasing awareness of the lifestyle effect on health.
   Conclusions: 1. The level of knowledge about non-pharmacological methods of preventing lifestyle diseases in the Polish population is high except of the role of physical activity and daily vegetables consumption. This, however, has no impact on reducing the percentage of overweight and obese people and on increasing the tendency to pursue lifestyle changes. 2. Frustrating is the fact that more than one fifth of the study population is unaware that excessive weight reduction prevents development of cardiovascular diseases. Moreover, the convince to early weight decreases with increasing BMI. 3. The highest level of the knowledge among younger subjects reflect improvement of health education in Polish population. 4. In addition to education performed by physician the main sources of patients knowledge are television and the press with the growing role of the Internet among younger. 5. Further health education programs are necessary, which should include not only activities that increase the level of health education and health awareness, but also aspects such as changes in beliefs, sense of self-efficacy and social support.
C1 [Olszanecka-Glinianowicz, Magdalena] Med Univ Silesia, Dept Pathophysiol, Hlth Promot & Obes Management Unit, Katowice, Poland.
   [Chudek, Jerzy] Med Univ Silesia, Dept Pathophysiol, Pathophysiol Unit, Katowice, Poland.
C3 Medical University of Silesia; Medical University of Silesia
RP Chudek, J (corresponding author), Dept Pathophysiol, Medykow 18, PL-40752 Katowice, Poland.
EM chj@poczta.fm
RI Chudek, Jerzy/I-2826-2019
OI Olszanecka-Glinianowicz, Magdalena/0000-0001-5632-5590; Chudek,
   Jerzy/0000-0002-6367-7794
FU Europharma M.Rachtan Sp. z o.o
FX The study was carried out as a research project supported by a grant
   from Europharma M.Rachtan Sp. z o.o.
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NR 40
TC 8
Z9 8
U1 0
U2 13
PU INST AGRICULTURAL MEDICINE
PI LUBLIN
PA JACZEWSKIEGO 2, PO BOX 185, 20-950 LUBLIN, POLAND
SN 1232-1966
EI 1898-2263
J9 ANN AGR ENV MED
JI Ann. Agr. Env. Med.
PY 2013
VL 20
IS 3
BP 559
EP 565
PG 7
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA 225LI
UT WOS:000324964000025
PM 24069865
DA 2025-06-11
ER

PT J
AU Yin, JJ
   Luo, YQ
   Deng, HL
   Qin, SM
   Tang, WJ
   Zeng, L
   Zhou, BJ
AF Yin, JinJin
   Luo, YanQin
   Deng, HouLiang
   Qin, ShuMin
   Tang, WaiJiao
   Zeng, Lu
   Zhou, BenJie
TI Hugan Qingzhi medication ameliorates hepatic steatosis by activating
   AMPK and PPARα pathways in L02 cells and HepG2 cells
SO JOURNAL OF ETHNOPHARMACOLOGY
LA English
DT Article
DE Hugan Qingzhi tablet; Hepatic steatosis; Oxidative stress; Adiponectin;
   AMPK; PPAR alpha
ID FATTY LIVER-DISEASE; PROTEIN-KINASE; INSULIN-RESISTANCE; TRANSCRIPTION
   FACTOR; METABOLIC SYNDROME; ENERGY-METABOLISM; LIPID-METABOLISM;
   ADIPONECTIN; ACID; MICE
AB Ethnopharmacological relevance: Hugan Qingzhi tablet (HQT), a lipid- lowering traditional Chinese medicine formula, has been used for the prevention and treatment of nonalcoholic fatty liver (NAFLD). Aim of the study: This study was realized to evaluate the effects of HQT-medicated serum on hepatic steatosis using in vitro experiments with cells and explore the relevant mechanisms with method of serum pharmacology.
   Materials and methods: A model of hepatic steatosis in the L02 and HepG2 cells was induced by free fatty acid (FFA). The components in the HQT-medicated serum were assayed by high-performance liquid chromatography. Intracellular lipid droplets were detected by Oil Red 0 staining, and their ultrastructure was examined by transmission electron microscope. The biochemical parameters, including triglyceride (TG), lactate dehydrogenase (LDH), aspartate aminotransferase (AST) and alanine aminotransferase (ALT), total antioxidant capacity (T-AOC), malondialdehyde (MDA), superoxide dismutase (SOD) and glutathione (GSH), were measured with commercial kits. Furthermore, the expression of adiponectin, AMP-activated protein kinase (AMPK) phosphorylation, sterol regulatory element-binding protein 1 (SREBP-1), peroxisome proliferator activated receptor-alpha (PPAR alpha), carnitine palmitoyltransferase 1 (CPT-1), and acetyl-CoA oxidase 1 (ACOX1) was analyzed by Western blot and/or quantitative reverse transcription-polymerase chain reaction (qRT-PCR).
   Results: Moderate- and high-dose HQT-medicated serum reduced (P < 0.05 or P < 0.01) the accumulation of lipid droplets and the cellular TG content in L02 and HepG2 cells. They caused significant reductions (P <0.01) in LDH, AST, ALT and MDA and significant increase (P <0.05 or P <0.01) in T-AOC in the culture medium. They also caused increase (P <0.05 or P < 0.01) in GSH level and SOD activity in FFA-induced steatotic L02 and HepG2 cells. Furthermore, moderate- and high-dose HQT-medicated serum enhanced (P < 0.01) adiponectin expression in a concentration-dependent manner and increased (P < 0.05 or P <0.01) the phosphorylation of AMPK and the expression of PPARa, CPT-1, and ACOX1, and reduced (P <0.05 or P <0.01) the expression of SREBP-1.
   Conclusion: The results suggested that HQT-medicated serum exerts a preventive effect against hepatic steatosis, and the potential mechanism might be activation of AMPK and PPARa pathways. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
C1 [Yin, JinJin; Deng, HouLiang; Tang, WaiJiao; Zeng, Lu; Zhou, BenJie] Southern Med Univ, Zhujiang Hosp, Ctr Drug Res & Dev, Guangzhou 510282, Guangdong, Peoples R China.
   [Luo, YanQin] Southern Med Univ, Nanfang Hosp, Dept Pharm, Guangzhou 510515, Guangdong, Peoples R China.
   [Qin, ShuMin] Shanghai Univ Tradit Chinese Med, Longhua Hosp, Inst Digest Dis, Shanghai 200032, Peoples R China.
C3 Southern Medical University - China; Southern Medical University -
   China; Shanghai University of Traditional Chinese Medicine
RP Zhou, BJ (corresponding author), Southern Med Univ, Zhujiang Hosp, Ctr Drug Res & Dev, Guangzhou 510282, Guangdong, Peoples R China.
EM zhoubj163@163.com
OI deng, houliang/0000-0002-7217-0063
FU Natural Science Foundation of China [81274160]; Natural Science
   Foundation of Guangdong Province [S2012010009380]; Science and
   Technology Development project of Guangdong province [2010B060900056]
FX This study was supported by grants from the Natural Science Foundation
   of China (No. 81274160), the Natural Science Foundation of Guangdong
   Province (No. S2012010009380) and the Science and Technology Development
   project of Guangdong province (No. 2010B060900056)
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NR 44
TC 62
Z9 70
U1 4
U2 123
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0378-8741
J9 J ETHNOPHARMACOL
JI J. Ethnopharmacol.
PD MAY 28
PY 2014
VL 154
IS 1
BP 229
EP 239
DI 10.1016/j.jep.2014.04.011
PG 11
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA AI6AQ
UT WOS:000336952600022
PM 24735863
DA 2025-06-11
ER

PT J
AU Arumugam, MK
   Gopal, T
   Kandy, RRK
   Boopathy, LK
   Perumal, SK
   Ganesan, M
   Rasineni, K
   Donohue, TM Jr
   Osna, NA
   Kharbanda, KK
AF Arumugam, Madan Kumar
   Gopal, Thiyagarajan
   Kandy, Rakhee Rathnam Kalari
   Boopathy, Lokesh Kumar
   Perumal, Sathish Kumar
   Ganesan, Murali
   Rasineni, Karuna
   Donohue Jr, Terrence M.
   Osna, Natalia A.
   Kharbanda, Kusum K.
TI Mitochondrial Dysfunction-Associated Mechanisms in the Development of
   Chronic Liver Diseases
SO BIOLOGY-BASEL
LA English
DT Review
DE mitochondria; metabolic-dysfunction-associated steatotic liver disease;
   alcohol-associated liver disease; liver; hepatocytes; steatotic liver
   diseases
ID NONALCOHOLIC FATTY LIVER; ELECTRON-TRANSPORT CHAIN; OXIDATIVE STRESS;
   SUPEROXIDE-PRODUCTION; COMPLEX II; TCA CYCLE; INSULIN-RESISTANCE; NLRP3
   INFLAMMASOME; REDOX HOMEOSTASIS; ROS GENERATION
AB Simple Summary Mitochondria are crucially important organelles involved in various metabolic activities, including energy generation. The involvement of mitochondrial dysfunction in the etiology of major chronic liver diseases, including alcohol-associated liver disease and metabolic-dysfunction-associated steatotic liver disease, is receiving increasing attention. This review summarizes the current literature on common mitochondrial defects, including the enhanced production of mitochondrial reactive oxygen species, impaired ATP production and mitochondria-mediated inflammatory responses and cell injury/death. Understanding mitochondrial dysfunction and its involvement in the pathogeneses of chronic liver diseases is important for developing innovative and efficient treatment options.Abstract The liver is a major metabolic organ that performs many essential biological functions such as detoxification and the synthesis of proteins and biochemicals necessary for digestion and growth. Any disruption in normal liver function can lead to the development of more severe liver disorders. Overall, about 3 million Americans have some type of liver disease and 5.5 million people have progressive liver disease or cirrhosis, in which scar tissue replaces the healthy liver tissue. An estimated 20% to 30% of adults have excess fat in their livers, a condition called steatosis. The most common etiologies for steatosis development are (1) high caloric intake that causes non-alcoholic fatty liver disease (NAFLD) and (2) excessive alcohol consumption, which results in alcohol-associated liver disease (ALD). NAFLD is now termed "metabolic-dysfunction-associated steatotic liver disease" (MASLD), which reflects its association with the metabolic syndrome and conditions including diabetes, high blood pressure, high cholesterol and obesity. ALD represents a spectrum of liver injury that ranges from hepatic steatosis to more advanced liver pathologies, including alcoholic hepatitis (AH), alcohol-associated cirrhosis (AC) and acute AH, presenting as acute-on-chronic liver failure. The predominant liver cells, hepatocytes, comprise more than 70% of the total liver mass in human adults and are the basic metabolic cells. Mitochondria are intracellular organelles that are the principal sources of energy in hepatocytes and play a major role in oxidative metabolism and sustaining liver cell energy needs. In addition to regulating cellular energy homeostasis, mitochondria perform other key physiologic and metabolic activities, including ion homeostasis, reactive oxygen species (ROS) generation, redox signaling and participation in cell injury/death. Here, we discuss the main mechanism of mitochondrial dysfunction in chronic liver disease and some treatment strategies available for targeting mitochondria.
C1 [Arumugam, Madan Kumar; Perumal, Sathish Kumar; Ganesan, Murali; Donohue Jr, Terrence M.; Osna, Natalia A.; Kharbanda, Kusum K.] Vet Affairs Nebraska Western Iowa Hlth Care Syst, Res Serv, Omaha, NE 68105 USA.
   [Arumugam, Madan Kumar; Perumal, Sathish Kumar; Ganesan, Murali; Donohue Jr, Terrence M.; Osna, Natalia A.; Kharbanda, Kusum K.] Univ Nebraska, Med Ctr, Dept Internal Med, Omaha, NE 68198 USA.
   [Arumugam, Madan Kumar] Sathyabama Inst Sci & Technol, Ctr Mol & Nanomed Sci, Canc Biol Lab, Chennai 600119, Tamil Nadu, India.
   [Gopal, Thiyagarajan; Boopathy, Lokesh Kumar] Sathyabama Inst Sci & Technol, Ctr Lab Anim Technol & Res, Chennai 600119, Tamil Nadu, India.
   [Kandy, Rakhee Rathnam Kalari] Univ Maryland, Dept Biochem & Mol Biol, Baltimore, MD 21201 USA.
   [Rasineni, Karuna; Donohue Jr, Terrence M.; Kharbanda, Kusum K.] Univ Nebraska, Med Ctr, Dept Biochem Mol Biol, Omaha, NE 68198 USA.
C3 US Department of Veterans Affairs; Veterans Health Administration (VHA);
   VA Nebraska-Western Iowa Health Care System; University of Nebraska
   System; University of Nebraska Medical Center; Sathyabama Institute of
   Science & Technology; Sathyabama Institute of Science & Technology;
   University System of Maryland; University of Maryland Baltimore;
   University of Nebraska System; University of Nebraska Medical Center
RP Kharbanda, KK (corresponding author), Vet Affairs Nebraska Western Iowa Hlth Care Syst, Res Serv, Omaha, NE 68105 USA.; Kharbanda, KK (corresponding author), Univ Nebraska, Med Ctr, Dept Internal Med, Omaha, NE 68198 USA.; Kharbanda, KK (corresponding author), Univ Nebraska, Med Ctr, Dept Biochem Mol Biol, Omaha, NE 68198 USA.
EM madankumarbio@gmail.com; mailthiyagarajang@gmail.com;
   rakheerathnam@gmail.com; lokeshkumarunom@gmail.com; perumal@unmc.edu;
   murali.ganesan@unmc.edu; karuna.rasineni@unmc.edu; tdonohue@unmc.edu;
   nosna@unmc.edu; kkharbanda@unmc.edu
RI Madan Kumar, Arumugam/AGT-2278-2022; Perumal, Sathish
   kumar/JBI-7520-2023; Arumugam, Madan Kumar/E-5278-2017; Booupathy,
   Lokeshkumar/HHN-0056-2022; Thiyagarajan, Gopal/AFO-0731-2022
OI Arumugam, Madan Kumar/0000-0003-0567-7857; KALARI KANDY, RAKHEE
   RATHNAM/0009-0007-1102-7929; Kharbanda, Kusum/0000-0001-7759-8889;
   Booupathy, Lokeshkumar/0000-0001-8730-7440; Osna,
   Natalia/0000-0001-7498-0556; Thiyagarajan, Gopal/0000-0003-1031-6300;
   Perumal, Sathish kumar/0000-0003-0151-521X; rasineni,
   Karuna/0000-0002-9581-3957
FU National Institute of Health [R01 AA026723]; US Department of Veterans
   Affairs, Biomedical Laboratory Research, and Development Service
   [BX004053, BX006064]
FX This work was supported by the National Institute of Health, grant R01
   AA026723 (K.K.K.) and Merit Review grants BX004053 (K.K.K.) and BX006064
   (K.K.K.) from the US Department of Veterans Affairs, Biomedical
   Laboratory Research, and Development Service.
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NR 218
TC 12
Z9 12
U1 6
U2 16
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2079-7737
J9 BIOLOGY-BASEL
JI Biology-Basel
PD OCT
PY 2023
VL 12
IS 10
AR 1311
DI 10.3390/biology12101311
PG 26
WC Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics
GA W8QX1
UT WOS:001094229600001
PM 37887021
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Kulik-Kupka, K
   Jabczyk, M
   Nowak, J
   Jagielski, P
   Hudzik, B
   Zubelewicz-Szkodzinska, B
AF Kulik-Kupka, Karolina
   Jabczyk, Marzena
   Nowak, Justyna
   Jagielski, Pawel
   Hudzik, Bartosz
   Zubelewicz-Szkodzinska, Barbara
TI Fetuin-A and Its Association with Anthropometric, Atherogenic, and
   Biochemical Parameters and Indices among Women with Polycystic Ovary
   Syndrome
SO NUTRIENTS
LA English
DT Article
DE fetuin-A; polycystic ovary syndrome; dyslipidemia; dysglycemia;
   anthropometric indices; BAI; VAI; ABSI; LAP; AIP; atherogenic
   coefficient; Castelli risk index-I; Castelli risk index-II
ID LIVER FAT-CONTENT; INSULIN-RESISTANCE; CARDIOVASCULAR-DISEASE; METABOLIC
   SYNDROME; OXIDATIVE STRESS; OBESITY; RISK; RATIO
AB Background: Polycystic ovary syndrome (PCOS) contributes to metabolic and endocrine complications for women of reproductive age. We set out to assess the relationship between fetuin-A and anthropometric parameters, anthropometric indices, body composition, and atherogenic indices, as well as carbohydrate and lipid profile in women with polycystic ovary syndrome (PCOS). Methods. The study included 49 women with PCOS, aged between 18 and 39 years. All patients were tested for fetuin-A, fasting glucose and insulin, and lipid parameters, after oral-glucose administration were done. All of them underwent anthropometric measurements and body composition analyses such as BMI (Body Mass Index), WHR (Waist to Hip Ratio), WHtR (Waist to Height Ratio), BAI (Body Adiposity Index), VAI (Visceral Adiposity Index), LAP (Lipid Accumulation Product), BRI (Body Roundness Index), ABSI (A Body Shape Index), ABSI z-core (ABSI with added mortality risk in correlation with age and gender), AIP (Atherogenic Risk of Plasma), AC (Atherogenic Coefficient), Castelli risk index-I, and Castelli risk index-II. Results: Obesity was diagnosed in 18 patients (36.7%) based on BMI index and 7 patients (14.3%) based on BAI index. Significantly increased risk of metabolic complications was observed among 26 patients (53.1%) based on waist circumferences. Based on VAI index, risk of metabolic disease was observed among 17 women (34.7%). Dyslipidemia such as hypercholesterolemia, hypertriglyceridemia, and mixed hyperlipidemia was detected among 14 patients (28.6%), and insulin resistance was observed among 29 (59.2%). There was a positive correlation between fetuin-A and total cholesterol (r = 0.30, p = 0.0034). There was no statistically significant correlation between fetuin-A and all of the anthropometric measurements and anthropometric indices, atherogenic indices, and other biochemical parameters. Conclusion: Fetuin-A correlates with hypercholesterolemia. It is necessary to conduct further research regarding the relationship between fetuin-A concentrations and body composition, anthropometric indices, and metabolic disorders in women with PCOS. Surprisingly, the effects of concentration of fetuin-A and anthropometric indices (BAI, VAI, LAP, ABSI, ABSI z-core) in woman with PCOS have not been closely examined. Future studies that take these variables into account will need to be undertaken. More information on the relationship between fetuin-A concentrations and anthropometric indices would aid us in establishing a greater degree of accuracy on this matter.
C1 [Kulik-Kupka, Karolina; Jabczyk, Marzena; Zubelewicz-Szkodzinska, Barbara] Med Univ Silesia, Fac Hlth Sci Bytom, Dept Nutr Related Dis Prevent, Dept Metab Dis Prevent, PL-41900 Bytom, Poland.
   [Nowak, Justyna; Hudzik, Bartosz] Med Univ Silesia, Fac Hlth Sci Bytom, Dept Cardiovasc Dis Prevent, Dept Metab Dis Prevent, PL-41900 Bytom, Poland.
   [Jagielski, Pawel] Jagiellonian Univ Med Coll, Fac Hlth Sci, Inst Publ Hlth, Dept Nutr & Drug Res, PL-31066 Krakow, Poland.
   [Hudzik, Bartosz] Med Univ Silesia, Fac Med Sci Zabrze, Silesian Ctr Heart Dis, Dept Cardiol 3, PL-41800 Zabrze, Poland.
   [Zubelewicz-Szkodzinska, Barbara] Dist Hosp, Dept Endocrinol, PL-41940 Piekary Slaskie, Poland.
C3 Medical University of Silesia; Medical University of Silesia;
   Jagiellonian University; Collegium Medicum Jagiellonian University;
   Medical University of Silesia; Silesian Center for Heart Diseases
RP Nowak, J (corresponding author), Med Univ Silesia, Fac Hlth Sci Bytom, Dept Cardiovasc Dis Prevent, Dept Metab Dis Prevent, PL-41900 Bytom, Poland.
EM justyna.nowak@sum.edu.pl
RI Hudzik, Bartosz/AAZ-8263-2020; Jagielski, Pawel/U-4944-2018
OI Jagielski, Pawel/0000-0001-7583-8965; Hudzik,
   Bartosz/0000-0003-3880-5325; Nowak, Justyna/0000-0002-0029-1341;
   Zubelewicz-Szkodzinska, Barbara/0000-0002-8670-8581; Jabczyk,
   Marzena/0000-0002-7767-6207
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WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 5I1OQ
UT WOS:000868135500001
PM 36235688
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Pinyol, R
   Torrecilla, S
   Wang, H
   Montironi, C
   Piqué-Gili, M
   Torres-Martin, M
   Wei-Qiang, L
   Willoughby, CE
   Ramadori, P
   Andreu-Oller, C
   Taik, P
   Lee, YA
   Moeini, A
   Peix, J
   Faure-Dupuy, S
   Riedl, T
   Schuehle, S
   Oliveira, CP
   Alves, VA
   Boffetta, P
   Lachenmayer, A
   Roessler, S
   Minguez, B
   Schirmacher, P
   Dufour, JF
   Thung, SN
   Reeves, HL
   Carrilho, FJ
   Chang, C
   Uzilov, AV
   Heikenwalder, M
   Sanyal, A
   Friedman, SL
   Sia, D
   Llovet, JM
AF Pinyol, Roser
   Torrecilla, Sara
   Wang, Huan
   Montironi, Carla
   Pique-Gili, Marta
   Torres-Martin, Miguel
   Wei-Qiang, Leow
   Willoughby, Catherine E.
   Ramadori, Pierluigi
   Andreu-Oller, Carmen
   Taik, Patricia
   Lee, Youngmin A.
   Moeini, Agrin
   Peix, Judit
   Faure-Dupuy, Suzanne
   Riedl, Tobias
   Schuehle, Svenja
   Oliveira, Claudia P.
   Alves, Venancio A.
   Boffetta, Paolo
   Lachenmayer, Anja
   Roessler, Stephanie
   Minguez, Beatriz
   Schirmacher, Peter
   Dufour, Jean-Francois
   Thung, Swan N.
   Reeves, Helen L.
   Carrilho, Flair J.
   Chang, Charissa
   Uzilov, Andrew, V
   Heikenwalder, Mathias
   Sanyal, Arun
   Friedman, Scott L.
   Sia, Daniela
   Llovet, Josep M.
TI Molecular characterisation of hepatocellular carcinoma in patients with
   non-alcoholic steatohepatitis
SO JOURNAL OF HEPATOLOGY
LA English
DT Article
DE liver cancer; obesity; metabolic syndrome; molecular class; mutational
   signature; animal model
ID GREATER-THAN-G; GENE-EXPRESSION SIGNATURE; MUTATIONS; VARIANT; RISK;
   NASH
AB Background and Aims: Non-alcoholic steatohepatitis (NASH)-related hepatocellular carcinoma (HCC) is increasing globally, but its molecular features are not well defined. We aimed to identify unique molecular traits characterising NASH-HCC compared to other HCC aetiologies.
   Methods: We collected 80 NASH-HCC and 125 NASH samples from 5 institutions. Expression array (n = 53 NASH-HCC; n = 74 NASH) and whole exome sequencing (n = 52 NASH-HCC) data were compared to HCCs of other aetiologies (n = 184). Three NASH-HCC mouse models were analysed by RNA-seq/expression-array (n = 20). Activin A receptor type 2A (ACVR2A) was silenced in HCC cells and proliferation assessed by colorimetric and colony formation assays.
   Results: Mutational profiling of NASH-HCC tumours revealed TERT promoter (56%), CTNNB1 (28%), TP53 (18%) and ACVR2A (10%) as the most frequently mutated genes. ACVR2A mutation rates were higher in NASH-HCC than in other HCC aetiologies (10% vs. 3%, p <0.05). In vitro, ACVR2A silencing prompted a significant increase in cell proliferation in HCC cells. We identified a novel mutational signature (MutSig-NASH-HCC) significantly associated with NASH-HCC (16% vs. 2% in viral/alcohol-HCC, p = 0.03). Tumour mutational burden was higher in non-cirrhotic than in cirrhotic NASH-HCCs (1.45 vs. 0.94 mutations/megabase; p <0.0017). Compared to other aetiologies of HCC, NASH-HCCs were enriched in bile and fatty acid signalling, oxidative stress and inflammation, and presented a higher fraction of Wnt/ TGF-beta proliferation subclass tumours (42% vs. 26%, p = 0.01) and a lower prevalence of the CTNNB1 subclass. Compared to other aetiologies, NASH-HCC showed a significantly higher prevalence of an immunosuppressive cancer field. In 3 murine models of NASH-HCC, key features of human NASH-HCC were preserved.
   Conclusions: NASH-HCCs display unique molecular features including higher rates of ACVR2A mutations and the presence of a newly identified mutational signature.
   Lay summary: The prevalence of hepatocellular carcinoma (HCC) associated with non-alcoholic steatohepatitis (NASH) is increasing globally, but its molecular traits are not well characterised. In this study, we uncovered higher rates of ACVR2A mutations (10%) - a potential tumour suppressor - and the presence of a novel mutational signature that characterises NASH-related HCC. (C) 2021 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
C1 [Pinyol, Roser; Torrecilla, Sara; Montironi, Carla; Pique-Gili, Marta; Torres-Martin, Miguel; Willoughby, Catherine E.; Andreu-Oller, Carmen; Moeini, Agrin; Peix, Judit; Llovet, Josep M.] Univ Barcelona, Hosp Clin, Inst Invest Biomed August Pi & Sunyer IDIBAPS, Liver Canc Translat Res Lab, Barcelona, Catalonia, Spain.
   [Wang, Huan; Taik, Patricia; Uzilov, Andrew, V] Sema4, Stamford, CT USA.
   [Torres-Martin, Miguel; Wei-Qiang, Leow; Andreu-Oller, Carmen; Lee, Youngmin A.; Boffetta, Paolo; Thung, Swan N.; Chang, Charissa; Friedman, Scott L.; Sia, Daniela; Llovet, Josep M.] Icahn Sch Med Mt Sinai, Tisch Canc Inst, Dept Hematol Oncol,Div Liver Dis, Dept Pathol,Mt Sinai Liver Canc Program,Dept Med, New York, NY 10029 USA.
   [Wei-Qiang, Leow] Singapore Gen Hosp, Dept Anat Pathol, Singapore, Singapore.
   [Ramadori, Pierluigi; Faure-Dupuy, Suzanne; Riedl, Tobias; Schuehle, Svenja; Heikenwalder, Mathias] German Canc Res Ctr Heidelberg DKFZ, Div Chron Inflammat & Canc, Heidelberg, Germany.
   [Lee, Youngmin A.] Vanderbilt Univ, Med Ctr, Dept Surg Sci, Nashville, TN USA.
   [Oliveira, Claudia P.; Alves, Venancio A.; Carrilho, Flair J.] Univ Sao Paulo, Sch Med, Dept Gastroenterol, Sao Paulo, Brazil.
   [Oliveira, Claudia P.; Alves, Venancio A.; Carrilho, Flair J.] Univ Sao Paulo, Sch Med, Dept Pathol, Sao Paulo, Brazil.
   [Boffetta, Paolo] Univ Bologna, Dept Med & Surg Sci, Bologna, Italy.
   [Lachenmayer, Anja; Dufour, Jean-Francois] Univ Bern, Bern Univ Hosp, Dept Visceral Surg & Med, CH-3010 Bern, Switzerland.
   [Roessler, Stephanie; Schirmacher, Peter] Univ Hosp Heidelberg, Inst Pathol, Heidelberg, Germany.
   [Minguez, Beatriz] Univ Autonoma Barcelona, Vall dHebron Hosp Univ, Vall dHebron Hosp Campus,Liver Unit, CIBERehd,Vall dHebron Inst Res VHIR,Liver Dis Res, Barcelona, Spain.
   [Reeves, Helen L.] Newcastle Univ, Translat & Clin Res Inst, Framlington Pl, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England.
   [Reeves, Helen L.] Newcastle Univ, Canc Med, Med Sch, Framlington Pl, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England.
   [Reeves, Helen L.] Newcastle Upon Tyne NHS Fdn Trust, Freeman Hosp, Hepatopancreatobiliary Multidisciplinary Team, Newcastle Upon Tyne, Tyne & Wear, England.
   [Uzilov, Andrew, V] Icahn Sch Med Mt Sinai, Dept Genet & Genom Sci, New York, NY 10029 USA.
   [Uzilov, Andrew, V] Icahn Sch Med Mt Sinai, Icahn Inst Data Sci & Genom Technol, New York, NY 10029 USA.
   [Sanyal, Arun] Virginia Commonwealth Univ, Div Gastroenterol, Richmond, VA USA.
   [Sanyal, Arun] Virginia Commonwealth Univ, Div Hepatol, Richmond, VA USA.
   [Llovet, Josep M.] Inst Catalana Recerca & Estudis Avancats, Barcelona, Catalonia, Spain.
C3 University of Barcelona; Hospital Clinic de Barcelona; IDIBAPS; Icahn
   School of Medicine at Mount Sinai; Singapore General Hospital; Helmholtz
   Association; German Cancer Research Center (DKFZ); Vanderbilt
   University; Universidade de Sao Paulo; Universidade de Sao Paulo;
   University of Bologna; University of Bern; University Hospital of Bern;
   Ruprecht Karls University Heidelberg; Autonomous University of
   Barcelona; Hospital Universitari Vall d'Hebron; Vall d'Hebron Institut
   de Recerca (VHIR); CIBER - Centro de Investigacion Biomedica en Red;
   CIBEREHD; Newcastle University - UK; Newcastle University - UK;
   Newcastle Upon Tyne Hospitals NHS Foundation Trust; Newcastle Freeman
   Hospital; Icahn School of Medicine at Mount Sinai; Icahn School of
   Medicine at Mount Sinai; Virginia Commonwealth University; Virginia
   Commonwealth University; ICREA
RP Llovet, JM (corresponding author), Icahn Sch Med Mt Sinai, Tisch Canc Inst, Div Liver Dis, Mt Sinai Liver Canc Program, New York, NY 10029 USA.
EM josep.llovet@mssm.edu
RI Ramadori, Pierluigi/AAZ-7533-2021; Lachenmayer, Anja/CAH-3461-2022;
   Carrilho, Flair/I-3046-2012; Willoughby, Catherine/AAA-4705-2019;
   Oliveira, Claudia/D-1216-2014; Dufour, Jean/AAL-9866-2020; Llovet, Josep
   M/ABB-6264-2021; Lee, Youngmin/KYQ-3944-2024; Pinyol,
   Roser/AAA-4404-2019; Boffetta, Paolo/AAI-7767-2021; Friedman,
   Scott/AFV-6304-2022; Llovet, Josep M/D-4340-2014; Minguez,
   Beatriz/N-4456-2014; Roessler, Stephanie/J-8432-2019; Faure-Dupuy,
   Suzanne/E-8094-2016
OI Llovet, Josep M/0000-0003-0547-2667; Wang, Huan/0000-0001-5628-5250;
   Andreu-Oller, Carmen/0000-0001-7405-9134; Minguez,
   Beatriz/0000-0002-7276-9666; Sia, Daniela/0000-0002-9000-611X; P
   Oliveira, Claudia/0000-0002-2848-417X; Riedl,
   Tobias/0000-0003-3236-4442; Carrilho, Flair Jose/0000-0002-7682-3105;
   Schuehle, Svenja/0000-0002-6992-7440; Willoughby,
   Catherine/0000-0002-0617-8833; Reeves, Helen/0000-0003-0359-9795; Leow,
   Wei Qiang/0000-0001-6003-9837; Roessler, Stephanie/0000-0002-5333-5942;
   Faure-Dupuy, Suzanne/0000-0001-7898-6795; Pinyol,
   Roser/0000-0002-0288-6314; Lachenmayer, Anja/0000-0002-5879-5737;
   Ramadori, Pierluigi/0000-0001-6581-9648; Torres Martin,
   Miguel/0000-0003-1589-8936
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NR 47
TC 158
Z9 163
U1 10
U2 98
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0168-8278
EI 1600-0641
J9 J HEPATOL
JI J. Hepatol.
PD OCT
PY 2021
VL 75
IS 4
BP 865
EP 878
DI 10.1016/j.jhep.2021.04.049
EA SEP 2021
PG 15
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA WA3DW
UT WOS:000702770800008
PM 34627652
OA Green Published, Bronze, Green Submitted
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Jahromi, MK
   Daftari, G
   Tehrani, AN
   Amirshekari, G
   Farhadnejad, H
   Teymoori, F
   Salehi-Sahlabadi, A
   Mirmiran, P
AF Jahromi, Mitra Kazemi
   Daftari, Ghazal
   Tehrani, Asal Neshatbini
   Amirshekari, Golshan
   Farhadnejad, Hossein
   Teymoori, Farshad
   Salehi-Sahlabadi, Ammar
   Mirmiran, Parvin
TI The association of the healthy food diversity index with the risk of
   non-alcoholic fatty liver disease among the adult population
SO CLINICAL NUTRITION ESPEN
LA English
DT Article
DE Dietary diversity; US healthy food diversity index; Non-alcoholic fatty
   liver disease; Adults
ID ENDOPLASMIC-RETICULUM STRESS; DIETARY DIVERSITY; METABOLIC SYNDROME;
   PHYSICAL-ACTIVITY; BODY ADIPOSITY; VARIETY; PREVALENCE; SCORE
AB Background and aim: Dietary diversity index is a useful evaluation index for examining the role of dietary pattern in predicting chronic diseases risk, including non-alcoholic fatty liver disease(NAFLD). In the present study, we aimed to examine the possible association of dietary diversity using US Healthy Food Diversity(US HFD) index and the NAFLD risk in Iranian adults. Methods: A total of 675 individuals (225 patients with NAFLD and 450 controls) aged 20-60 years were recruited for the current case-control study. Data on dietary intakes were determined using a validated food frequency questionnaire, and dietary diversity was calculated using the US HFD index. In patients with NAFLD, an ultrasound scan of the liver was used to detect NAFLD. Logistic regression models were used to estimate the odds ratios(ORs) and 95 % confidence interval(CI) of NAFLD across tertiles of the US HFD index. Results: Mean +/- SD age of the study population were 38.13 +/- 8.85 years. The median (interquartile) score of the US HFD index in patients with NAFLD and healthy subjects was 0.08(0.07-0.09) and 0.09(0.08-0.10), respectively. In the age and sex-adjusted model, the odds of NAFLD were considerably reduced across tertiles of the US HFD index (OR:0.48; 95%CI:0.32-0.72, P-trend<0.001). Also, in the final model, after adjusting for age, sex, waist-to-hip ratio, smoking, physical activity, marital status, socioeconomic status, and energy intake, the odds of NAFLD were significantly reduced across tertiles US HFD index (OR:0.55; 95%CI:0.31-0.97, P-trend<0.001). Furthermore, for each SD increase in the US HFD index, the odds of NAFLD are reduced by 23 % (OR:0.77;95%CI:0.60-0.97,P-Value<0.001). Conclusions: Our findings revealed that greater adherence to dietary pattern with a high US HFD score, defined by higher intakes of fruits, vegetables, whole grains, legumes, nuts, low-fat dairy, seeds, soya products, and plant oils may be related to reducing the odds of NAFLD. (c) 2023 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights reserved.
C1 [Jahromi, Mitra Kazemi] Hormozgan Univ Med Sci, Endocrinol & Metab Res Ctr, Bandar Abbas, Iran.
   [Daftari, Ghazal] Univ Tehran Med Sci, Sch Med, Tehran, Iran.
   [Tehrani, Asal Neshatbini] Ahvaz Jundishapur Univ Med Sci, Student Res Comm, Ahvaz, Iran.
   [Tehrani, Asal Neshatbini] Ahvaz Jundishapur Univ Med Sci, Sch Allied Med Sci, Dept Nutr, Ahvaz, Iran.
   [Amirshekari, Golshan] Shahid Beheshti Univ Med Sci, Res Inst Endocrine Sci, Endocrine Res Ctr, Tehran, Iran.
   [Farhadnejad, Hossein; Teymoori, Farshad; Mirmiran, Parvin] Shahid Beheshti Univ Med Sci, Res Inst Endocrine Sci, Nutr & Endocrine Res Ctr, Tehran, Iran.
   [Teymoori, Farshad] Iran Univ Med Sci, Sch Publ Hlth, Dept Nutr, Tehran, Iran.
   [Salehi-Sahlabadi, Ammar] Shahid Beheshti Univ Med Sci, Natl Nutr & Food Technol Res Inst, Fac Nutr & Food Technol, Dept Clin Nutr & Dietet, Tehran, Iran.
   [Salehi-Sahlabadi, Ammar] Isfahan Univ Med Sci, Sch Nutr & Food Sci, Dept Community Nutr, Esfahan, Iran.
C3 Tehran University of Medical Sciences; Ahvaz Jundishapur University of
   Medical Sciences (AJUMS); Ahvaz Jundishapur University of Medical
   Sciences (AJUMS); Shahid Beheshti University Medical Sciences; Shahid
   Beheshti University Medical Sciences; Iran University of Medical
   Sciences; Shahid Beheshti University Medical Sciences; Isfahan
   University of Medical Sciences
RP Teymoori, F; Mirmiran, P (corresponding author), Shahid Beheshti Univ Med Sci, Res Inst Endocrine Sci, Nutr & Endocrine Res Ctr, Tehran, Iran.
EM teymoori.f@iums.ac.ir; mirmiran@endocrine.ac.ir
RI salehi-sahlabadi, ammar/KHD-7718-2024; Neshatbini Tehrani,
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   Mitra/V-1943-2017; Farhadnejad, Hossein/H-1405-2018; Daftari,
   Ghazal/IZD-7434-2023
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NR 55
TC 2
Z9 2
U1 0
U2 3
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2405-4577
J9 CLIN NUTR ESPEN
JI Clin. Nutr. ESPEN
PD FEB
PY 2024
VL 59
BP 404
EP 411
DI 10.1016/j.clnesp.2023.12.144
EA JAN 2024
PG 8
WC Nutrition & Dietetics
WE Emerging Sources Citation Index (ESCI)
SC Nutrition & Dietetics
GA GW4Z3
UT WOS:001155709600001
PM 38220403
DA 2025-06-11
ER

PT J
AU Xie, ZJ
   Novograd, J
   Itzkowitz, Y
   Sher, A
   Buchen, YD
   Sodhi, K
   Abraham, NG
   Shapiro, JI
AF Xie, Zi-jian
   Novograd, Joel
   Itzkowitz, Yaakov
   Sher, Ariel
   Buchen, Yosef D.
   Sodhi, Komal
   Abraham, Nader G.
   Shapiro, Joseph, I
TI The Pivotal Role of Adipocyte-Na K peptide in Reversing Systemic
   Inflammation in Obesity and COVID-19 in the Development of Heart Failure
SO ANTIOXIDANTS
LA English
DT Review
DE Na; K-ATPase; reactive oxygen species; coronavirus disease; heme
   oxygenase; obesity; adipocytes; heart failure
ID EPICARDIAL ADIPOSE-TISSUE; IMPROVES INSULIN SENSITIVITY; HEME OXYGENASE;
   CYTOKINE STORM; COMORBIDITY INCREASE; VASCULAR DYSFUNCTION;
   ATRIAL-FIBRILLATION; METABOLIC SYNDROME; OXIDATIVE STRESS; PERICARDIAL
   FAT
AB This review summarizes data from several laboratories that have demonstrated a role of the Na/K-ATPase, specifically its alpha 1 subunit, in the generation of reactive oxygen species (ROS) via the negative regulator of Src. Together with Src and other signaling proteins, the Na/K-ATPase forms an oxidant amplification loop (NKAL), amplifies ROS, and participates in cytokines storm in obesity. The development of a peptide fragment of the alpha 1 subunit, NaKtide, has been shown to negatively regulate Src. Several groups showed that the systemic administration of the cell permeable modification of NaKtide (pNaKtide) or its selective delivery to fat tissue-adipocyte specific expression of NaKtide-ameliorate the systemic elevation of inflammatory cytokines seen in chronic obesity. Severe acute respiratory syndrome - coronavirus 2 (SARS-CoV-2), the RNA Coronavirus responsible for the COVID-19 global pandemic, invades cells via the angiotensin converting enzyme 2 (ACE-2) receptor (ACE2R) that is appended in inflamed fat tissue and exacerbates the formation of the cytokines storm. Both obesity and heart and renal failure are well known risks for adverse outcomes in patients infected with COVID-19. White adipocytes express ACE-2 receptors in high concentration, especially in obese patients. Once the virus invades the white adipocyte cell, it creates a COVID19-porphyrin complex which degrades and produces free porphyrin and iron and increases ROS. The increased formation of ROS and activation of the NKAL results in a further potentiated formation of ROS production, and ultimately, adipocyte generation of more inflammatory mediators, leading to systemic cytokines storm and heart failure. Moreover, chronic obesity also results in the reduction of antioxidant genes such as heme oxygenase-1 (HO-1), increasing adipocyte susceptibility to ROS and cytokines. It is the systemic inflammation and cytokine storm which is responsible for many of the adverse outcomes seen with COVID-19 infections in obese subjects, leading to heart failure and death. This review will also describe the potential antioxidant drugs and role of NaKtide and their demonstrated antioxidant effect used as a major strategy for improving obesity and epicardial fat mediated heart failure in the context of the COVID pandemic.
C1 [Xie, Zi-jian; Sodhi, Komal; Abraham, Nader G.; Shapiro, Joseph, I] Marshall Univ, Joan C Edwards Sch Med, Huntington, WV 25755 USA.
   [Novograd, Joel; Itzkowitz, Yaakov; Sher, Ariel; Buchen, Yosef D.; Abraham, Nader G.] New York Med Coll, Dept Med, Valhalla, NY 10595 USA.
C3 Marshall University; New York Medical College
RP Abraham, NG; Shapiro, JI (corresponding author), Marshall Univ, Joan C Edwards Sch Med, Huntington, WV 25755 USA.; Abraham, NG (corresponding author), New York Med Coll, Dept Med, Valhalla, NY 10595 USA.
EM jnovogra@student.nymc.edu; yitzkowitz90@gmail.com;
   asher@student.touro.edu; ybuchen@student.nymc.edu; sodhi@marshall.edu;
   nader_abraham@nymc.edu; ShapiroJ@marshall.edu
OI Abraham, Nader/0000-0001-8983-1959
FU National Institutes of Health [HL34300, R56-139561]
FX This work is supported by National Institutes of Health grant [HL34300
   to NGA]. The content is solely the responsibility of the authors and
   does not necessarily represent the official views of the National
   Institutes of Health. The study was supported by R56-139561.
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NR 135
TC 7
Z9 7
U1 1
U2 8
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD NOV
PY 2020
VL 9
IS 11
AR 1129
DI 10.3390/antiox9111129
PG 22
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA OW6NY
UT WOS:000593002200001
PM 33202598
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Chang, E
   Kim, L
   Park, SE
   Rhee, EJ
   Lee, WY
   Oh, KW
   Park, SW
   Park, CY
AF Chang, Eugene
   Kim, Lisa
   Park, Se Eun
   Rhee, Eun-Jung
   Lee, Won-Young
   Oh, Ki-Won
   Park, Sung-Woo
   Park, Cheol-Young
TI Ezetimibe improves hepatic steatosis in relation to autophagy in obese
   and diabetic rats
SO WORLD JOURNAL OF GASTROENTEROLOGY
LA English
DT Article
DE Autophagy; Ezetimibe; Hepatic steatosis; Nonalcoholic fatty liver
   disease
ID FATTY LIVER-DISEASE; ENDOPLASMIC-RETICULUM STRESS; INSULIN-RESISTANCE;
   CHOLESTEROL ABSORPTION; METABOLIC SYNDROME; MICE; DIET; YEAST;
   STEATOHEPATITIS; COMPLICATIONS
AB AIM: To investigate whether ezetimibe ameliorates hepatic steatosis and induces autophagy in a rat model of obesity and type 2 diabetes.
   METHODS: Male age-matched lean control LETO and obese and diabetic OLETF rats were administered either PBS or ezetimibe (10 mg/kg per day) via stomach gavage for 20 wk. Changes in weight gain and energy intake were regularly monitored. Blood and liver tissue were harvested after overnight fasting at the end of study. Histological assessment was performed in liver tissue. The concentrations of glucose, insulin, triglycerides (TG), free fatty acids (FFA), and total cholesterol (TC) in blood and TG, FFA, and TG in liver tissue were measured. mRNA and protein abundance involved in autophagy was analyzed in the liver. To investigate the effect of ezetimibe on autophagy and reduction in hepatic fat accumulation, human Huh7 hepatocytes were incubated with ezetimibe (10 mu mol/L) together with or without palmitic acid (PA, 0.5 mmol/L, 24 h). Transmission electron microscopy (TEM) was employed to demonstrate effect of ezetimibe on autophagy formation. Autophagic flux was measured with bafilomycin A1, an inhibitor of autophagy and following immunoblotting for autophagy-related protein expression.
   RESULTS: In the OLETF rats that received ezetimibe (10 mg/kg per day), liver weight were significantly decreased by 20% compared to OLETF control rats without changes in food intake and body weight (P < 0.05). Lipid parameters including TG, FFA, and TC in liver tissue of ezetimibe-administrated OLETF rats were dramatically decreased at least by 30% compared to OLETF controls (P < 0.01). The serum glucose, insulin, HOMA-IR, and lipid profiles were also improved by ezetimibe (P < 0.05). In addition, autophagy-related mRNA expression including ATG5, ATG6, and ATG7 and the protein level of microtubule-associated protein light chain 3 (LC3) were significantly increased in the liver in rats that received ezetimibe (P < 0.05). Likewise, for hepatocytes cultured in vitro, ezetimibe treatment significantly decreased PA-induced fat accumulation and increased PA-reduced mRNA and protein expression involved in autophagy (P < 0.05). Ezetimibe-increased autophagosomes was observed in TEM analysis. Immunoblotting analysis of autophagy formation with an inhibitor of autophagy demonstrated that ezetimibe-increased autophagy resulted from increased autophagic flux.
   CONCLUSION: The present study demonstrates that ezetimibe-mediated improvement in hepatic steatosis might involve the induction of autophagy.
C1 [Chang, Eugene] Ewha Womans Univ, Dept Nutr Sci & Food Management, Seoul 120750, South Korea.
   [Kim, Lisa; Park, Cheol-Young] Sungkyunkwan Univ, Sch Med, Diabet Res Inst, Kangbuk Samsung Hosp, Seoul 110746, South Korea.
   [Park, Se Eun; Rhee, Eun-Jung; Lee, Won-Young; Oh, Ki-Won; Park, Sung-Woo; Park, Cheol-Young] Sungkyunkwan Univ, Sch Med, Div Endocrinol & Metab, Dept Internal Med,Kangbuk Samsung Hosp, Seoul 110746, South Korea.
C3 Ewha Womans University; Sungkyunkwan University (SKKU); Samsung Medical
   Center; Sungkyunkwan University (SKKU); Samsung Medical Center
RP Park, CY (corresponding author), Sungkyunkwan Univ, Sch Med, Div Endocrinol & Metab, Dept Internal Med,Kangbuk Samsung Hosp, 108 Pyung Dong, Seoul 110746, South Korea.
EM cydoctor@chol.com
RI park, sung woo/JTS-5921-2023; Rhee, Eun-Jung/M-9294-2015; LEE,
   WON-YOUNG/C-7249-2018
OI Rhee, Eun-Jung/0000-0002-6108-7758; LEE, WON-YOUNG/0000-0002-1082-7592
FU Samsung Biomedical Research Institute [SBRI C-B1-111-3]; National
   Research Foundation of Korea [2012R1A1A2009143/2013027171]; Korean
   Diabetes Association [2014S-1]
FX Supported by Samsung Biomedical Research Institute, Grant No. SBRI
   C-B1-111-3; National Research Foundation of Korea, No.
   2012R1A1A2009143/2013027171; and Korean Diabetes Association (to Park
   CY, 2014S-1)
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NR 50
TC 30
Z9 33
U1 0
U2 15
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 8226 REGENCY DR, PLEASANTON, CA 94588 USA
SN 1007-9327
EI 2219-2840
J9 WORLD J GASTROENTERO
JI World J. Gastroenterol.
PD JUL 7
PY 2015
VL 21
IS 25
BP 7754
EP 7763
DI 10.3748/wjg.v21.i25.7754
PG 10
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA CM3LW
UT WOS:000357584700012
PM 26167075
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Li, B
   Zhang, FZ
   Jiang, HQ
   Wang, C
   Zhao, QH
   Yang, WS
   Hu, AL
AF Li, Bin
   Zhang, Fengzhan
   Jiang, Haoqi
   Wang, Chen
   Zhao, Qihong
   Yang, Wanshui
   Hu, Anla
TI Adequate Intake of Dietary Fiber May Relieve the Detrimental Impact of
   Blood Lead on Dyslipidemia among US Adults: A Study of Data from the
   National Health and Nutrition Examination Survey Database
SO NUTRIENTS
LA English
DT Article
DE lead; dyslipidemia; dietary fiber; National Health and Nutrition
   Examination Survey
ID OXIDATIVE STRESS; QUALITY-CONTROL; INFLAMMATION; EXPOSURE
AB Lead (Pb) exposure is a well-established risk factor for dyslipidemia, and people are exposed to it in multiple ways daily. Dietary fiber is presumed to improve lipid metabolism disorders, but it is still unknown whether it can relieve the detrimental impact of Pb on dyslipidemia. We used publicly accessible data from the 2011-2016 cycles of the National Health and Nutrition Examination Survey (NHANES). A total of 2128 US adults were enrolled for the subsequent analysis. Heavy metal concentrations in blood were measured using inductively coupled plasma mass spectrometry (ICP-MS). A weighted logistic regression was conducted to calculate odds ratios (ORs) and 95% confidence intervals (CIs). The dose-response relationship between blood heavy metals and dyslipidemia was explored using a weighted restricted cubic spline (RCS) analysis. After fully adjusting for potential confounding factors (age, gender, race, education level, ratio of family income to poverty, marital status, body mass index, physical activity, waist circumference, smoke, alcohol drinking and history of metabolic syndrome, hypertension, and diabetes), a positive association between blood Pb levels and dyslipidemia risk was revealed (OR = 1.20, 95% CI: 1.03-1.40). Dietary fiber intake may significantly modify the association between blood Pb levels and dyslipidemia (p-interaction = 0.049), with a stronger association (OR = 1.26, 95% CI: 1.05-1.52) being revealed in individuals with an inadequate intake of dietary fiber (<14 g/1000 kcal/day), but a null association (OR = 1.01, 95% CI: 0.72-1.42) being observed in those with an adequate intake of dietary fiber (>= 14 g/1000 kcal/day). Moreover, the weighted RCS analysis showed that compared with the average blood Pb exposure level (4.24 <mu>g/dL), a lower blood Pb exposure level (3.08 mu g/dL) may contribute to the risk of dyslipidemia in the group with an inadequate dietary fiber intake. Our findings suggest that Pb exposure in blood may be a risk factor for dyslipidemia. However, an adequate dietary fiber intake may offset the risk of dyslipidemia caused by blood Pb exposure. Since avoiding Pb exposure in daily life is difficult, increasing dietary fiber intake in the future might be a promising approach to alleviate dyslipidemia caused by Pb exposure.
C1 [Li, Bin; Zhang, Fengzhan; Jiang, Haoqi; Wang, Chen; Zhao, Qihong; Yang, Wanshui; Hu, Anla] Anhui Med Univ, Ctr Big Data & Populat Hlth IHM, Sch Publ Hlth, Dept Nutr & Food Hyg, 81 Meishan Rd, Hefei 230032, Peoples R China.
C3 Anhui Medical University
RP Hu, AL (corresponding author), Anhui Med Univ, Ctr Big Data & Populat Hlth IHM, Sch Publ Hlth, Dept Nutr & Food Hyg, 81 Meishan Rd, Hefei 230032, Peoples R China.
EM lb19990920@163.com; zfz2286880392@163.com; jhq0716@163.com;
   unciawang@126.com; qihong@ahmu.edu.cn; wanshuiyang@gmail.com;
   huanla@ahmu.edu.cn
RI Zhao, Qihong/GWV-8029-2022; Wang, Chen/KFS-8530-2024; Yang,
   Wanshui/S-9322-2019
OI Hu, Anla/0000-0003-3611-8572; Zhao, Qihong/0000-0002-7894-5691; Yang,
   Wanshui/0000-0002-7365-2689
FU The authors are thankful for publicly available data provided by the
   National Health and Nutrition Examination Survey.
FX The authors are thankful for publicly available data provided by the
   National Health and Nutrition Examination Survey.
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NR 45
TC 6
Z9 6
U1 3
U2 7
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD OCT
PY 2023
VL 15
IS 20
AR 4434
DI 10.3390/nu15204434
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA X3ZE8
UT WOS:001097862500001
PM 37892509
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Shinjyo, N
   Parkinson, J
   Bell, J
   Katsuno, T
   Bligh, A
AF Shinjyo, Noriko
   Parkinson, James
   Bell, Jimmy
   Katsuno, Tatsuro
   Bligh, Annie
TI Berberine for prevention of dementia associated with diabetes and its
   comorbidities: A systematic review
SO JOURNAL OF INTEGRATIVE MEDICINE-JIM
LA English
DT Article
DE Berberine; Diabetes; Dementia; Alzheimer's disease; Vascular dementia
ID ACTIVATED PROTEIN-KINASE; HIGH-FAT DIET; PERFORMANCE
   LIQUID-CHROMATOGRAPHY; BRAIN INSULIN-RESISTANCE; BETA-AMYLOID PATHOLOGY;
   CENTRAL-NERVOUS-SYSTEM; ALZHEIMERS-DISEASE; COGNITIVE IMPAIRMENT;
   OXIDATIVE STRESS; HIGH GLUCOSE
AB Background: A growing number of epidemiological studies indicate that metabolic syndrome (MetS) and its associated features play a key role in the development of certain degenerative brain disorders, including Alzheimer's disease and vascular dementia. Produced by several different medicinal plants, berberine is a bioactive alkaloid with a wide range of pharmacological effects, including antidiabetic effects. However, it is not clear whether berberine could prevent the development of dementia in association with diabetes.
   Objective: To give an overview of the therapeutic potential of berberine as a treatment for dementia associated with diabetes.
   Search strategy: Database searches A and B were conducted using PubMed and ScienceDirect. In search A, studies on berberine's antidementia activities were identified using "berberine" and "dementia" as search terms. In search B, recent studies on berberine's effects on diabetes were surveyed using "berberine" and "diabetes" as search terms.
   Inclusion criteria: Clinical and preclinical studies that investigated berberine's effects associated with MetS and cognitive dysfunction were included. Data extraction and analysis: Data from studies were extracted by one author, and checked by a second; quality assessments were performed independently by two authors.
   Results: In search A, 61 articles were identified, and 22 original research articles were selected. In search B, 458 articles were identified, of which 101 were deemed relevant and selected. Three duplicates were removed, and a total of 120 articles were reviewed for this study. The results demonstrate that berberine exerts beneficial effects directly in the brain: enhancing cholinergic neurotransmission, improving cerebral blood flow, protecting neurons from inflammation, limiting hyperphosphorylation of tau and facilitating beta-amyloid peptide clearance. In addition, evidence is growing that berberine is effective against diabetes and associated disorders, such as atherosclerosis, cardiomyopathy, hypertension, hepatic steatosis, diabetic nephropathy, gut dysbiosis, retinopathy and neuropathy, suggesting indirect benefits for the prevention of dementia.
   Conclusion: Berberine could impede the development of dementia via multiple mechanisms: preventing brain damages and enhancing cognition directly in the brain, and indirectly through alleviating risk factors such as metabolic dysfunction, and cardiovascular, kidney and liver diseases. This study provided evidence to support the value of berberine in the prevention of dementia associated with MetS. (C) 2020 Shanghai Changhai Hospital. Published by Elsevier B.V. All rights reserved.
C1 [Shinjyo, Noriko] Chiba Univ, Grad Sch Med, Dept Infect & Host Def, Chuo Ku, Chiba 2608670, Japan.
   [Parkinson, James; Bell, Jimmy] Univ Westminster, Fac Sci & Technol, Dept Life Sci, London W1W 6UW, England.
   [Katsuno, Tatsuro] Chiba Univ Hosp, Kashiwanoha Clin East Asian Med, Kashiwa, Chiba 2770882, Japan.
   [Bligh, Annie] Caritas Inst Higher Educ, Sch Hlth Sci, Tseung Kwan O, Hong Kong 999077, Peoples R China.
C3 Chiba University; University of Westminster; Chiba University; Saint
   Francis University Hong Kong
RP Shinjyo, N (corresponding author), Chiba Univ, Grad Sch Med, Dept Infect & Host Def, Chuo Ku, Chiba 2608670, Japan.; Bell, J (corresponding author), Univ Westminster, Fac Sci & Technol, Dept Life Sci, London W1W 6UW, England.; Bligh, A (corresponding author), Caritas Inst Higher Educ, Sch Hlth Sci, Tseung Kwan O, Hong Kong 999077, Peoples R China.
EM nshinjyo@chiba-u.jp; J.Bell@westminster.ac.uk; abligh@cihe.edu.hk
RI ; Bligh, S W Annie/AAI-9786-2020
OI Shinjyo, Noriko/0000-0003-4501-4513; Bell, Jimmy/0000-0003-3804-1281;
   Bligh, S W Annie/0000-0002-4757-2159
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NR 230
TC 33
Z9 34
U1 2
U2 43
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2095-4964
J9 J INTEGR MED-JIM
JI J. Integr. Med.-JIM
PD MAR
PY 2020
VL 18
IS 2
BP 125
EP 151
DI 10.1016/j.joim.2020.01.004
PG 27
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA KU8WN
UT WOS:000519993900005
PM 32005442
OA Green Published
DA 2025-06-11
ER

EF﻿FN Clarivate Analytics Web of Science
VR 1.0
PT J
AU Drescher, HK
   Weiskirchen, R
   Fülöp, A
   Hopf, C
   de San Román, EG
   Huesgen, PF
   de Bruin, A
   Bongiovanni, L
   Christ, A
   Tolba, R
   Trautwein, C
   Kroy, DC
AF Drescher, Hannah K.
   Weiskirchen, Ralf
   Fueloep, Annabelle
   Hopf, Carsten
   de San Roman, Estibaliz Gonzalez
   Huesgen, Pitter F.
   de Bruin, Alain
   Bongiovanni, Laura
   Christ, Annette
   Tolba, Rene
   Trautwein, Christian
   Kroy, Daniela C.
TI The Influence of Different Fat Sources on Steatohepatitis and Fibrosis
   Development in the Western Diet Mouse Model of Non-alcoholic
   Steatohepatitis (NASH)
SO FRONTIERS IN PHYSIOLOGY
LA English
DT Article
DE non-alcoholic steatohepatitis; Western diet; fatty liver; fibrosis;
   animal model and liver injury
ID LIVER-TRANSPLANTATION; HEPATIC STEATOSIS; OXIDATIVE STRESS; TRIGLYCERIDE
   SYNTHESIS; OBESE MICE; CORN-OIL; FISH-OIL; ACIDS; INFLAMMATION;
   CHOLESTEROL
AB Non-alcoholic steatohepatitis (NASH) is the leading cause of chronic liver injury and the third most common reason for liver transplantations in Western countries. It is unclear so far how different fat sources in Western diets (WD) influence the development of NASH. Our study investigates the impact of non-trans fat (NTF) and corn oil (Corn) as fat source in a WD mouse model of steatohepatitis on disease development and progression. C57BL/6J wildtype (WT) mice were fed "standard" WD (WD-Std), WDNTF or WD-Corn for 24 weeks. WT animals treated with WD-NTF exhibit distinct features of the metabolic syndrome compared to WD-Std and WD-Corn. This becomes evident by a worsened insulin resistance and elevated serum ALT, cholesterol and triglyceride (TO) levels compared to WD-Corn. Animals fed WD-Corn on the contrary tend to a weakened disease progression in the described parameters. After 24 weeks feeding with WD-NTF and WD-Std, WD-Corn lead to a comparable steatohepatitis initiation by histomorphological changes and immune cell infiltration compared to WD-Std. Immune cell infiltration results in a significant increase in mRNA expression of the pro-inflammatory cytokines IL-6 and TNF-alpha, which is more pronounced in WD-NTF compared to WD-Std and WD-Corn. Interestingly the fat source has no impact on the composition of accumulating fat within liver tissue as determined by matrix-assisted laser desorption/ionization mass spectrometry imaging of multiple lipid classes. The described effects of different fat sources on the development of steatohepatitis finally resulted in variations in fibrosis development. Animals treated with WD-NTF displayed massive collagen accumulation, whereas WD-Corn even seems to protect from extracellular matrix deposition. Noteworthy, WD-Corn provokes massive histomorphological modifications in epididymal white adipose tissue (eWAT) and severe accumulation of extracellular matrix which are not apparent in WD-Std and WDNTF treatment. Different fat sources in WD-Std contribute to strong steatohepatitis development in WT mice after 24 weeks treatment. Surprisingly, corn oil provokes histomorphological changes in eWAT tissue. Accordingly, both WD-NTF and WD-Corn appear suitable as alternative dietary treatment to replace "standard" WD-Std as a diet mouse model of steatohepatitis whereas WD-Corn leads to strong changes in eWAT morphology.
C1 [Drescher, Hannah K.; Trautwein, Christian; Kroy, Daniela C.] Univ Hosp RWTH Aachen, Dept Internal Med 3, Aachen, Germany.
   [Weiskirchen, Ralf] Univ Hosp RWTH Aachen, IFMPEGKC, Inst Mol Pathobiochem Expt Gene Therapy & Clin Ch, Aachen, Germany.
   [Fueloep, Annabelle; Hopf, Carsten] Mannheim Univ Appl Sci, Ctr Biomed Mass Spectrometry & Opt Spect CeMOS, Mannheim, Germany.
   [de San Roman, Estibaliz Gonzalez; Huesgen, Pitter F.] Forschungszentrum Julich, ZEA 3, Cent Inst Engn Elect & Analyt, Julich, Germany.
   [de Bruin, Alain; Bongiovanni, Laura] Univ Utrecht, Fac Vet Med, Dept Pathobiol, Utrecht, Netherlands.
   [Christ, Annette] Univ Hosp Bonn, Inst Innate Immun, Bonn, Germany.
   [Christ, Annette] Univ Massachusetts, Sch Med, Dept Infect Dis & Immunol, Worcester, MA USA.
   [Tolba, Rene] Univ Hosp RWTH Aachen, Inst Lab Anim Sci & Expt Surg, Aachen, Germany.
   [Tolba, Rene] Univ Hosp RWTH Aachen, Cent Lab Lab Anim Sci, Aachen, Germany.
C3 RWTH Aachen University; RWTH Aachen University Hospital; RWTH Aachen
   University; RWTH Aachen University Hospital; Helmholtz Association;
   Research Center Julich; Utrecht University; University of Bonn;
   University of Massachusetts System; University of Massachusetts
   Worcester; RWTH Aachen University; RWTH Aachen University Hospital; RWTH
   Aachen University; RWTH Aachen University Hospital
RP Drescher, HK (corresponding author), Univ Hosp RWTH Aachen, Dept Internal Med 3, Aachen, Germany.
EM hannah.drescher@rwth-aachen.de
RI de Bruin, Alain/AAL-9195-2020; Hopf, Carsten/A-3275-2015; Huesgen,
   Pitter/E-9246-2019; Weiskirchen, Ralf/O-1734-2018
OI Hopf, Carsten/0000-0003-0802-6451; de Bruin, Alain/0000-0001-8579-2649;
   Huesgen, Pitter/0000-0002-0335-2242; Weiskirchen,
   Ralf/0000-0003-3888-0931; Gonzalez de San Roman,
   Estibaliz/0000-0001-5440-2695; Fulop, Annabelle/0000-0003-0938-1092;
   Drescher, Hannah/0000-0001-9945-1239
FU Deutsche Forschungsgemeinschaft DFG [SFB/TRR 57]
FX This work was supported by the SFB/TRR 57 of the Deutsche
   Forschungsgemeinschaft DFG to DCK, CT, and RW.
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NR 54
TC 25
Z9 26
U1 1
U2 18
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-042X
J9 FRONT PHYSIOL
JI Front. Physiol.
PD JUN 25
PY 2019
VL 10
AR 770
DI 10.3389/fphys.2019.00770
PG 17
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA IF6RF
UT WOS:000473207100001
PM 31293441
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Wong, H
   Wong, MCS
   Wong, SYS
   Lee, A
AF Wong, Hidy
   Wong, Martin C. S.
   Wong, Samuel Y. S.
   Lee, Albert
TI The association between shift duty and abnormal eating behavior among
   nurses working in a major hospital: A cross-sectional study
SO INTERNATIONAL JOURNAL OF NURSING STUDIES
LA English
DT Article
DE Shift duty; Nurses; Abnormal eating behavior; Emotional eating; External
   eating; Restraint eating
ID METABOLIC SYNDROME; HEALTH; ENVIRONMENT; WORKERS; HABITS; LIFE
AB Background: Shift work induces stress, disturbs family life and interrupts regular meal schedules. Few studies have addressed the association between shift duties and abnormal eating behavior among hospital nurses.
   Objectives and design: We tested the hypothesis that shift duties were independent predictors of abnormal eating. Self-administered surveys consisting of socio-demographic data, working pattern, Perceived Organizational Support (POS) questionnaire and the patterns of eating style identified by the Dutch Eating Behavior Questionnaires (DEBQ) were used.
   Settings: One major acute hospital in one Territory of Hong Kong.
   Participants: All 662 nurses who worked on a full-time basis in this hospital were invited to join the study and among them, 378 completed surveys were collected with a response rate of 57.1%. The average age was 37.2 years, and 91.5% were female. 67.3 were registered nurses, 17.9% enrolled nurses; and 14.5% were ranked nursing officers or above. 39.1% worked in acute settings (medical wards, intensive care units and emergency departments), and 62.1% of respondents had at least 11 years of clinical experience and 76.2% of respondents had shift duties with 81.9% having at least four shift duties per month. Only 66.7% of respondents had normal body mass index (BMI 18.5-22.9 kg/m(2)).
   Methods: Three binary logistic regression analyses were conducted with abnormal emotional, external and restraint DEBQ as outcome variables, respectively. We controlled for age, gender, marital status, work setting (acute vs. non-acute), years of clinical experience, the frequency of shift duties, body mass index, perception of body weight changes in the past 6 months, self-perception of recent overeating and POS.
   Results: The proportions of participants having abnormal emotional, external and restraint DEBQ scores were 66.4%, 61.4% and 64.0%, respectively. From multiple regression analysis, nurses having 4 or more shift duties per month were more likely to present with abnormal emotional (adjusted odds ratio aOR 2.91, 95% C.I. 1.57-5.42, p = 0.001) and restraint (aOR 3.35, 95% C.I. 1.76-6.38, p < 0.001) DEBS scores.
   Conclusions: Shift duties were positively associated with abnormal eating behavior among nurses working in hospitals. More health promotional initiatives should be targeted towards hospital nurses whose duties require frequent night shifts to enhance healthy eating. (C) 2010 Elsevier Ltd. All rights reserved.
C1 [Wong, Hidy; Wong, Martin C. S.; Wong, Samuel Y. S.; Lee, Albert] Chinese Univ Hong Kong, Fac Med, Sch Publ Hlth & Primary Care, Hong Kong, Hong Kong, Peoples R China.
C3 Chinese University of Hong Kong
RP Wong, MCS (corresponding author), Prince Wales Hosp, Sch Publ Hlth Bldg, 4-F, Shatin, Hong Kong, Peoples R China.
EM drwong_martin@yahoo.com.hk; wong_martin@cuhk.edu.hk
RI Lee, Albert/M-2743-2019; Wong, Martin/L-4568-2014; Wong, Samuel
   Yeung-shan/D-7311-2013
OI Wong, Martin/0000-0001-7706-9370; Wong, Samuel
   Yeung-shan/0000-0003-0934-6385
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NR 37
TC 78
Z9 101
U1 1
U2 31
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0020-7489
EI 1873-491X
J9 INT J NURS STUD
JI Int. J. Nurs. Stud.
PD AUG
PY 2010
VL 47
IS 8
BP 1021
EP 1027
DI 10.1016/j.ijnurstu.2010.01.001
PG 7
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA 631JO
UT WOS:000280343000013
PM 20116059
DA 2025-06-11
ER

PT J
AU Murphy, CC
   Zaki, TA
AF Murphy, Caitlin C.
   Zaki, Timothy A.
TI Changing epidemiology of colorectal cancer - birth cohort effects and
   emerging risk factors
SO NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
LA English
DT Review
ID BODY-MASS INDEX; NONCARDIA GASTRIC-CANCER; ATOMIC-BOMB SURVIVORS;
   EARLY-LIFE EXPOSURES; AGE-PERIOD-COHORT; OXIDATIVE STRESS; METABOLIC
   SYNDROME; SUBSEQUENT RISK; DDT EXPOSURE; LUNG-CANCER
AB Incidence and mortality of colorectal cancer (CRC) are increasing worldwide, suggesting broad changes in the epidemiology of CRC. In this Review, we discuss the changes that are becoming evident, including trends in CRC incidence and mortality by age and birth cohort, and consider the contributions of early-life exposures and emerging risk factors to these changes. Importantly, incidence of CRC has increased among people born since the early 1950s in nearly all regions of the world. These so-called birth cohort effects imply the involvement of factors that influence the earliest stages of carcinogenesis and have effects across the life course. Accumulating evidence supports the idea that early-life exposures are important risk factors for CRC, including exposures during fetal development, childhood, adolescence and young adulthood. Environmental chemicals could also have a role because the introduction of many in the 1950s and 1960s coincides with increasing incidence of CRC among people born during those years. To reverse the expected increases in the global burden of CRC, participation in average-risk screening programmes needs to be increased by scaling up and implementing evidence-based screening strategies, and emerging risk factors responsible for these increases need to be identified.
   In this Review, Murphy and Zaki discuss changes in the incidence and mortality of colorectal cancer, including trends by age and birth cohort, and consider the contributions of early-life exposures and emerging risk factors.
   Incidence and mortality of colorectal cancer (CRC) are increasing worldwide, suggesting broad changes in the epidemiology of CRC.The incidence of CRC has increased among people born since the early 1950s in nearly all regions of the world; so-called birth cohort effects.Birth cohort effects implicate factors that influence the earliest stages of carcinogenesis and have effects across the life course.Accumulating evidence supports the idea that early-life exposures, including those during fetal development, childhood, adolescence and young adulthood, are important risk factors for CRC.Environmental chemicals could have a role in birth cohort effects because the introduction of many in the 1950s and 1960s coincides with increasing incidence of CRC among people born during those years.To prevent expected increases in the global burden of CRC, participation in average-risk screening programmes needs to be increased, and emerging risk factors responsible for the increases need to be identified.
C1 [Murphy, Caitlin C.] Univ Texas Hlth Sci Ctr Houston UTHealth Houston, Dept Hlth Promot & Behav Sci, Sch Publ Hlth, Houston, TX 77030 USA.
   [Zaki, Timothy A.] Univ Texas Southwestern Med Ctr, Dept Internal Med, Dallas, TX USA.
   [Zaki, Timothy A.] UCLA, David Geffen Sch Med, Dept Med, Los Angeles, CA USA.
C3 University of Texas System; University of Texas Health Science Center
   Houston; University of Texas School Public Health; University of Texas
   System; University of Texas Southwestern Medical Center Dallas;
   University of California System; University of California Los Angeles;
   University of California Los Angeles Medical Center; David Geffen School
   of Medicine at UCLA
RP Murphy, CC (corresponding author), Univ Texas Hlth Sci Ctr Houston UTHealth Houston, Dept Hlth Promot & Behav Sci, Sch Publ Hlth, Houston, TX 77030 USA.
EM caitlin.c.murphy@uth.tmc.edu
OI Zaki, Timothy/0000-0003-0299-5171; Murphy, Caitlin/0000-0001-9365-0691
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NR 150
TC 65
Z9 68
U1 13
U2 53
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 1759-5045
EI 1759-5053
J9 NAT REV GASTRO HEPAT
JI Nat. Rev. Gastroenterol. Hepatol.
PD JAN
PY 2024
VL 21
IS 1
BP 25
EP 34
DI 10.1038/s41575-023-00841-9
EA SEP 2023
PG 10
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA EH7T2
UT WOS:001069057000001
PM 37723270
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Bourgeois, C
   Gorwood, J
   Olivo, A
   Le Pelletier, L
   Capeau, J
   Lambotte, O
   Béréziat, V
   Lagathu, C
AF Bourgeois, Christine
   Gorwood, Jennifer
   Olivo, Anaelle
   Le Pelletier, Laura
   Capeau, Jacqueline
   Lambotte, Olivier
   Bereziat, Veronique
   Lagathu, Claire
TI Contribution of Adipose Tissue to the Chronic Immune Activation and
   Inflammation Associated With HIV Infection and Its Treatment
SO FRONTIERS IN IMMUNOLOGY
LA English
DT Review
DE adipose tissue; HIV infection; fat; antiretroviral treatment; chronic
   inflammation; chronic immune activation
ID BODY-MASS INDEX; REVERSE-TRANSCRIPTASE INHIBITORS; MITOCHONDRIAL-DNA
   HAPLOGROUPS; NECROSIS-FACTOR-ALPHA; INSULIN-RESISTANCE; T-CELLS;
   ANTIRETROVIRAL THERAPY; GENE-EXPRESSION; METABOLIC SYNDROME;
   SUBCUTANEOUS FAT
AB White adipose tissue (AT) contributes significantly to inflammation - especially in the context of obesity. Several of AT's intrinsic features favor its key role in local and systemic inflammation: (i) large distribution throughout the body, (ii) major endocrine activity, and (iii) presence of metabolic and immune cells in close proximity. In obesity, the concomitant pro-inflammatory signals produced by immune cells, adipocytes and adipose stem cells help to drive local inflammation in a vicious circle. Although the secretion of adipokines by AT is a prime contributor to systemic inflammation, the lipotoxicity associated with AT dysfunction might also be involved and could affect distant organs. In HIV-infected patients, the AT is targeted by both HIV infection and antiretroviral therapy (ART). During the primary phase of infection, the virus targets AT directly (by infecting AT CD4 T cells) and indirectly (via viral protein release, inflammatory signals, and gut disruption). The initiation of ART drastically changes the picture: ART reduces viral load, restores (at least partially) the CD4 T cell count, and dampens inflammatory processes on the whole-body level but also within the AT. However, ART induces AT dysfunction and metabolic side effects, which are highly dependent on the individual molecules and the combination used. First generation thymidine reverse transcriptase inhibitors predominantly target mitochondrial DNA and induce oxidative stress and adipocyte death. Protease inhibitors predominantly affect metabolic pathways (affecting adipogenesis and adipocyte homeostasis) resulting in insulin resistance. Recently marketed integrase strand transfer inhibitors induce both adipocyte adipogenesis, hypertrophy and fibrosis. It is challenging to distinguish between the respective effects of viral persistence, persistent immune defects and ART toxicity on the inflammatory profile present in ART-controlled HIV-infected patients. The host metabolic status, the size of the pre-established viral reservoir, the quality of the immune restoration, and the natural ageing with associated comorbidities may mitigate and/or reinforce the contribution of antiretrovirals (ARVs) toxicity to the development of low-grade inflammation in HIV-infected patients. Protecting AT functions appears highly relevant in ART-controlled HIV-infected patients. It requires lifestyle habits improvement in the absence of effective anti-inflammatory treatment. Besides, reducing ART toxicities remains a crucial therapeutic goal.
C1 [Bourgeois, Christine; Olivo, Anaelle; Lambotte, Olivier] Univ Paris Saclay, Ctr Immunol Viral Infect & Autoimmune Dis, IDMIT Dept, IBFJ,CEA,INSERM,U1184, Fontenay Aux Roses, France.
   [Gorwood, Jennifer; Le Pelletier, Laura; Capeau, Jacqueline; Bereziat, Veronique; Lagathu, Claire] Sorbonne Univ, Ctr Rech St Antoine, UMR S 938, INSERM,Inst Hosp Univ Cardiometab & Nutr ICAN, FRM EQU201903007868, Paris, France.
   [Lambotte, Olivier] Grp Hosp Univ Paris Saclay, Serv Med Interne & Immunal Clin, Hop Bicetre, AP HP, Le Kremlin Bicetre, France.
C3 CEA; Universite Paris Saclay; Institut National de la Sante et de la
   Recherche Medicale (Inserm); Sorbonne Universite; Institut National de
   la Sante et de la Recherche Medicale (Inserm); Assistance Publique
   Hopitaux Paris (APHP); Hopital Universitaire Antoine-Beclere - APHP;
   Hopital Universitaire Bicetre - APHP; Universite Paris Saclay
RP Bourgeois, C (corresponding author), Univ Paris Saclay, Ctr Immunol Viral Infect & Autoimmune Dis, IDMIT Dept, IBFJ,CEA,INSERM,U1184, Fontenay Aux Roses, France.; Béréziat, V; Lagathu, C (corresponding author), Sorbonne Univ, Ctr Rech St Antoine, UMR S 938, INSERM,Inst Hosp Univ Cardiometab & Nutr ICAN, FRM EQU201903007868, Paris, France.
EM christine.bourgeois@u-psud.fr; claire.lagathu@inserm.fr
RI Bourgeois, Christine/ABA-1432-2021; Lambotte, Olivier/GRT-0160-2022
OI Lambotte, Olivier/0000-0003-4425-8516; BEREZIAT,
   Veronique/0000-0002-9795-549X; Lagathu, Claire/0000-0003-0700-8286;
   Olivo, Anaelle/0000-0001-5090-2115
FU French National Research Agency for HIV and Viral Hepatitis (ANRS);
   French National Research Agency [ANR15-RHUS-0003]; Sidaction; DIM
   OneHealth; Fondation Dormeur; Gilead
FX The research was funded by the French National Research Agency for HIV
   and Viral Hepatitis (ANRS), the French National Research Agency
   (reference: RHU CARMMA ANR15-RHUS-0003), Sidaction, DIM OneHealth,
   Fondation Dormeur, and Gilead.
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NR 206
TC 19
Z9 19
U1 0
U2 8
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-3224
J9 FRONT IMMUNOL
JI Front. Immunol.
PD JUN 18
PY 2021
VL 12
AR 670566
DI 10.3389/fimmu.2021.670566
PG 22
WC Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology
GA TC8ZT
UT WOS:000668927500001
PM 34220817
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Nicolaides, NC
   Ioannidi, MK
   Koniari, E
   Papageorgiou, I
   Bartzeliotou, A
   Sertedaki, A
   Klapa, MI
   Charmandari, E
AF Nicolaides, Nicolas C.
   Ioannidi, Maria-Konstantina
   Koniari, Eleni
   Papageorgiou, Ifigeneia
   Bartzeliotou, Anastasia
   Sertedaki, Amalia
   Klapa, Maria, I
   Charmandari, Evangelia
TI Untargeted Plasma Metabolomics Unravels a Metabolic Signature for Tissue
   Sensitivity to Glucocorticoids in Healthy Subjects: Its Implications in
   Dietary Planning for a Healthy Lifestyle
SO NUTRIENTS
LA English
DT Article
DE tissue glucocorticoid sensitivity in healthy adults; dietary planning;
   glucocorticoid receptor; untargeted GC-MS metabolomics; blood plasma
   metabolic signature; precision medicine
ID RECEPTOR GENE; POLYMORPHISMS; MECHANISMS; RESISTANCE; ASSOCIATION;
   EXPRESSION; MANAGEMENT; DISEASE; STRESS; TM4
AB In clinical practice, differences in glucocorticoid sensitivity among healthy subjects may influence the outcome and any adverse effects of glucocorticoid therapy. Thus, a fast and accurate methodology that could enable the classification of individuals based on their tissue glucocorticoid sensitivity would be of value. We investigated the usefulness of untargeted plasma metabolomics in identifying a panel of metabolites to distinguish glucocorticoid-resistant from glucocorticoid-sensitive healthy subjects who do not carry mutations in the human glucocorticoid receptor (NR3C1) gene. Applying a published methodology designed for the study of glucocorticoid sensitivity in healthy adults, 101 healthy subjects were ranked according to their tissue glucocorticoid sensitivity based on 8:00 a.m. serum cortisol concentrations following a very low-dose dexamethasone suppression test. Ten percent of the cohort, i.e., 11 participants, on each side of the ranking, with no NR3C1 mutations or polymorphisms, were selected, respectively, as the most glucocorticoid-sensitive and most glucocorticoid-resistant of the cohort to be analyzed and compared with untargeted blood plasma metabolomics using gas chromatography-mass spectrometry (GC-MS). The acquired metabolic profiles were evaluated using multivariate statistical analysis methods. Nineteen metabolites were identified with significantly lower abundance in the most sensitive compared to the most resistant group of the cohort, including fatty acids, sugar alcohols, and serine/threonine metabolism intermediates. These results, combined with a higher glucose, sorbitol, and lactate abundance, suggest a higher Cori cycle, polyol pathway, and inter-tissue one-carbon metabolism rate and a lower fat mobilization rate at the fasting state in the most sensitive compared to the most resistant group. In fact, this was the first study correlating tissue glucocorticoid sensitivity with serine/threonine metabolism. Overall, the observed metabolic signature in this cohort implies a worse cardiometabolic profile in the most glucocorticoid-sensitive compared to the most glucocorticoid-resistant healthy subjects. These findings offer a metabolic signature that distinguishes most glucocorticoid-sensitive from most glucocorticoid-resistant healthy subjects to be further validated in larger cohorts. Moreover, they support the correlation of tissue glucocorticoid sensitivity with insulin resistance and metabolic syndrome-associated pathways, further emphasizing the need for nutritionists and doctors to consider the tissue glucocorticoid sensitivity in dietary and exercise planning, particularly when these subjects are to be treated with glucocorticoids.
C1 [Nicolaides, Nicolas C.; Koniari, Eleni; Papageorgiou, Ifigeneia; Sertedaki, Amalia; Charmandari, Evangelia] Natl & Kapodistrian Univ Athens, Aghia Sophia Childrens Hosp, Dept Pediat 1, Div Endocrinol Metab & Diabet,Med Sch, Athens 11527, Greece.
   [Nicolaides, Nicolas C.; Charmandari, Evangelia] Acad Athens, Ctr Clin Expt Surg & Translat Res, Div Endocrinol & Metab, Biomed Res Fdn, Athens 11528, Greece.
   [Ioannidi, Maria-Konstantina; Klapa, Maria, I] Fdn Res & Technol Hellas FORTH ICE HT, Inst Chem Engn Sci, Metab Engn & Syst Biol Lab, Patras 26504, Greece.
   [Ioannidi, Maria-Konstantina] Univ Patras, Dept Biol, Patras 26500, Greece.
   [Bartzeliotou, Anastasia] Natl & Kapodistrian Univ Athens, Aghia Sophia Childrens Hosp, Dept Clin Biochem, Med Sch, Athens 11527, Greece.
C3 The Aghia Sophia Children's Hospital; National & Kapodistrian University
   of Athens; Academy of Athens; Foundation for Research & Technology -
   Hellas (FORTH); Institute of Chemical Engineering Sciences (ICE-HT);
   University of Patras; National & Kapodistrian University of Athens; The
   Aghia Sophia Children's Hospital
RP Charmandari, E (corresponding author), Natl & Kapodistrian Univ Athens, Aghia Sophia Childrens Hosp, Dept Pediat 1, Div Endocrinol Metab & Diabet,Med Sch, Athens 11527, Greece.; Charmandari, E (corresponding author), Acad Athens, Ctr Clin Expt Surg & Translat Res, Div Endocrinol & Metab, Biomed Res Fdn, Athens 11528, Greece.; Klapa, MI (corresponding author), Fdn Res & Technol Hellas FORTH ICE HT, Inst Chem Engn Sci, Metab Engn & Syst Biol Lab, Patras 26504, Greece.
EM nicolaidesnc@gmail.com; m.k.ioannidi@gmail.com; helenia8@yahoo.it;
   ifipap88@gmail.com; anbartz@ymail.com; aserted@med.uoa.gr;
   mklapa@iceht.forth.gr; evangelia.charmandari@googlemail.com
RI Charmandari, Evangelia/AAF-2038-2019; KLAPA, MARIA/ITT-8426-2023
OI Ioannidi, Maria-Konstantina/0000-0001-7914-8363; Charmandari,
   Evangelia/0000-0002-0851-6998
FU European Regional Development Fund of the European Union; Greek national
   funds through the Operational Program Competitiveness, Entrepreneurship
   and Innovation, under the call RESEARCH-CREATE-INNOVATE [T1EDK-01386,
   MIS: 5030543]; project "EATRIS-GR: Infrastructure for preclinical and
   early-phase clinical development of drugs, therapeutics and biomedical
   devices" - operational program "Competitiveness, Entrepreneurship and
   Innovation"(NSRF 2014-2020) [MIS 5028091]; project "ELIXIR-GR: The Greek
   Research Infrastructure for Data Management and Analysis in Life
   Sciences" - operational program "Competitiveness, Entrepreneurship and
   Innovation"(NSRF 2014-2020) [MIS 5002780]; project "INSPIRED: The
   National Research Infrastructures on Integrated Structural Biology, Drug
   Screening Efforts and Drug target functional characterisation" -
   operational program "Competitiveness, Entrepreneurship and
   Innovation"(NSRF 2014-2020) [MIS 5002550]; European Union (European
   Regional Development Fund); project "BITAD: Advanced Research Activities
   in Biomedical and Agroalimentary Technologies" - operational program
   "Competitiveness, Entrepreneurship and Innovation"(NSRF 2014-2020)
FX The clinical study was co-financed by the European Regional Development
   Fund of the European Union and Greek national funds through the
   Operational Program Competitiveness, Entrepreneurship and Innovation,
   under the call RESEARCH-CREATE-INNOVATE (project code: T1EDK-01386, MIS:
   5030543, Acronym: PEDOBESITY). The metabolomic and bioinformatic
   analyses at FORTH/ICE-HT were supported by the project "BITAD: Advanced
   Research Activities in Biomedical and Agroalimentary Technologies" (MIS
   5002469), implemented under the "Action for the Strategic Development on
   the Research and Technological Sector", and the projects "EATRIS-GR:
   Infrastructure for preclinical and early-phase clinical development of
   drugs, therapeutics and biomedical devices" (MIS 5028091), "ELIXIR-GR:
   The Greek Research Infrastructure for Data Management and Analysis in
   Life Sciences" (MIS 5002780), and "INSPIRED: The National Research
   Infrastructures on Integrated Structural Biology, Drug Screening Efforts
   and Drug target functional characterisation" (MIS 5002550), implemented
   under the action "Reinforcement of the Research and Innovation
   Infrastructure", all four funded by the operational program
   "Competitiveness, Entrepreneurship and Innovation"(NSRF 2014-2020) and
   co-financed by Greece and the European Union (European Regional
   Development Fund).
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NR 59
TC 6
Z9 6
U1 1
U2 11
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JUN
PY 2021
VL 13
IS 6
AR 2120
DI 10.3390/nu13062120
PG 14
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA SZ1FP
UT WOS:000666320500001
PM 34205537
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Gaike, AH
   Paul, D
   Bhute, S
   Dhotre, DP
   Pande, P
   Upadhyaya, S
   Reddy, Y
   Sampath, R
   Ghosh, D
   Chandraprabha, D
   Acharya, J
   Banerjee, G
   Sinkar, VP
   Ghaskadbi, SS
   Shouche, YS
AF Gaike, Akshay H.
   Paul, Dhiraj
   Bhute, Shrikant
   Dhotre, Dhiraj P.
   Pande, Pranav
   Upadhyaya, Smitha
   Reddy, Yugandhar
   Sampath, Ramya
   Ghosh, Debjani
   Chandraprabha, D.
   Acharya, Jhankar
   Banerjee, Gautam
   Sinkar, Vilas P.
   Ghaskadbi, Saroj S.
   Shouche, Yogesh S.
TI The Gut Microbial Diversity of Newly Diagnosed Diabetics but Not of
   Prediabetics Is Significantly Different from That of Healthy
   Nondiabetics
SO MSYSTEMS
LA English
DT Article
DE 16S rRNA gene; T2D; driver genera; gut microbiome; newly diagnosed
   diabetics; prediabetes; serum biomarkers; total antioxidants
ID INSULIN-RESISTANCE; OXIDATIVE STRESS; INTESTINAL MICROBIOTA; BACTERIAL
   DIVERSITY; BRANCHED-CHAIN; OBESITY; INFLAMMATION; INDIVIDUALS;
   ASSOCIATION; METABOLISM
AB Type 2 diabetes (T2D) is a complex metabolic syndrome characterized by insulin dysfunction and abnormalities in glucose and lipid metabolism. The gut microbiome has been recently identified as an important factor for development of T2D. In this study, a total of 102 subjects were recruited, and we have looked at the gut microbiota of prediabetics (PreDMs) (n = 17), newly diagnosed diabetics (NewDMs) (n = 11), and diabetics on antidiabetic treatment (KnownDMs) (n = 39) and compared them with healthy nondiabetics (ND) (n = 35). Twenty-five different serum biomarkers were measured to assess the status of diabetes and their association with gut microbiota. Our analysis revealed nine different genera as differentially abundant in four study groups. Among them, Akkermansia, Blautia, and Ruminococcus were found to be significantly (P = 0.05) decreased, while Lactobacillus was increased in NewDMs compared to ND and recovered in KnownDMs. Akkermansia was inversely correlated with HbA1c and positively correlated with total antioxidants. Compared to ND, there was increased abundance of Megasphaera, Escherichia, and Acidaminococcus and decreased abundance of Sutterella in KnownDMs. Among many taxa known to act as community drivers during disease progression, we observed genus Sutterella as a common driver taxon among all diabetic groups. On the basis of the results of random forest analysis, we found that the genera Akkermansia and Sutterella and that the serum metabolites fasting glucose, HbA1c, methionine, and total antioxidants were highly discriminative factors among studied groups. Taken together, our data revealed that gut microbial diversity of NewDMs but not of PreDMs is significantly different from that of ND. Interestingly, after antidiabetic treatment, the microbial diversity of KnownDMs tends to recover toward that of ND.
   IMPORTANCE Gut microbiota is considered to play a role in disease progression, and previous studies have reported an association of microbiome dysbiosis with T2D. In this study, we have attempted to investigate gut microbiota of ND, PreDMs, NewDMs, and KnownDMs. We found that the genera Akkermansia and Blautia decreased significantly (P = 0.05) in treatment-naive diabetics and were restored in KnownDMs on antidiabetic treatment. To the best of our knowledge, comparative studies on shifts in the microbial community in individuals of different diabetic states are lacking. Understanding the transition of microbiota and its association with serum biomarkers in diabetics with different disease states may pave the way for new therapeutic approaches for T2D.
C1 [Gaike, Akshay H.; Paul, Dhiraj; Dhotre, Dhiraj P.; Pande, Pranav; Sinkar, Vilas P.; Shouche, Yogesh S.] Natl Ctr Cell Sci, Natl Ctr Microbial Resource, Pune, Maharashtra, India.
   [Upadhyaya, Smitha; Reddy, Yugandhar; Sampath, Ramya; Ghosh, Debjani; Chandraprabha, D.; Banerjee, Gautam] Unilever R&D, Bangalore, Karnataka, India.
   [Gaike, Akshay H.; Bhute, Shrikant; Acharya, Jhankar; Ghaskadbi, Saroj S.] Savitribai Phule Pune Univ, Dept Zool, Pune, Maharashtra, India.
   [Bhute, Shrikant] Univ Nevada, Sch Life Sci, Las Vegas, NV 89154 USA.
   [Pande, Pranav] Univ Quebec, Ctr INRS, Inst Armand Frappier, Inst Natl Rech Sci, Laval, PQ, Canada.
   [Pande, Pranav] Univ Montreal, Inst Rech Biol Vet, Montreal, PQ, Canada.
   [Pande, Pranav] Jardin Bot Montreal, Montreal, PQ, Canada.
   [Banerjee, Gautam] Tata Chem Innovat Ctr, Pune, Maharashtra, India.
C3 Department of Biotechnology (DBT) India; National Centre for Cell
   Science, Pune (NCCS); Unilever; Savitribai Phule Pune University; Nevada
   System of Higher Education (NSHE); University of Nevada Las Vegas;
   University of Quebec; Institut national de la recherche scientifique
   (INRS); Universite de Montreal; Tata Sons; Tata Chemicals Limited
RP Shouche, YS (corresponding author), Natl Ctr Cell Sci, Natl Ctr Microbial Resource, Pune, Maharashtra, India.; Ghaskadbi, SS (corresponding author), Savitribai Phule Pune Univ, Dept Zool, Pune, Maharashtra, India.
EM ssg@unipune.ac.in; yogesh@nccs.res.in
RI Bhute, Shrikant/ABD-2437-2021
OI Gaike, Akshay/0000-0002-5355-3018; Banerjee, Gautam/0000-0001-5595-8521
FU Unilever R&D, Bangalore, India; Department of Science and Technology
   (DST), Government of India
FX This study was supported by Unilever R&D, Bangalore, India. D.P.
   acknowledges the Department of Science and Technology (DST), Government
   of India, for fellowship.
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NR 70
TC 79
Z9 86
U1 2
U2 14
PU AMER SOC MICROBIOLOGY
PI WASHINGTON
PA 1752 N ST NW, WASHINGTON, DC 20036-2904 USA
SN 2379-5077
J9 MSYSTEMS
JI mSystems
PD MAR-APR
PY 2020
VL 5
IS 2
AR e00578-19
DI 10.1128/mSystems.00578-19
PG 17
WC Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Microbiology
GA LK7YM
UT WOS:000531077500013
PM 32234773
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Tinkov, AA
   Sinitskii, AI
   Popova, EV
   Nemereshina, ON
   Gatiatulina, ER
   Skalnaya, MG
   Skalny, AV
   Nikonorov, AA
AF Tinkov, Alexey A.
   Sinitskii, Anton I.
   Popova, Elizaveta V.
   Nemereshina, Olga N.
   Gatiatulina, Evgenia R.
   Skalnaya, Margarita G.
   Skalny, Anatoly V.
   Nikonorov, Alexandr A.
TI Alteration of local adipose tissue trace element homeostasis as a
   possible mechanism of obesity-related insulin resistance
SO MEDICAL HYPOTHESES
LA English
DT Article
ID CHROMIUM DINICOCYSTEINATE SUPPLEMENTATION; NF-KAPPA-B; ZINC
   SUPPLEMENTATION; METABOLIC SYNDROME; OXIDATIVE STRESS; VANADYL SULFATE;
   IN-VIVO; PICOLINATE SUPPLEMENTATION; TYROSINE PHOSPHORYLATION;
   BLOOD-GLUCOSE
AB The mechanisms of association between obesity and the related metabolic disturbances in general and insulin resistance in particular are extensively studied. Taking into account a key role of adipose tissue insulin resistance in the development of systemic obesity-related insulin resistance, the estimation of mechanisms linking increased adiposity and impaired insulin signaling in adipocytes will allow to develop novel prophylactic and therapeutic approaches to treatment of these states. A number of trace elements like chromium, zinc, and vanadium have been shown to take part in insulin signaling via various mechanisms. Taking into account a key role of adipocyte in systemic carbohydrate homeostasis it can be asked if trace element homeostasis in adipose tissue may influence regulatory mechanisms of glucose metabolism. We hypothesize that caloric excess through currently unknown mechanisms results in decreased chromium, vanadium, and zinc content in adipocytes. Decreased content of trace elements in the adipose tissue causes impairment of intra-adipocyte insulin signaling subsequently leading to adipose tissue insulin resistance. The latter significantly contributes to systemic insulin resistance and further metabolic disruption in obesity. It is also possible that decreased adipose tissue trace element content is associated with dysregulation of insulin-sensitizing and proinflammatory adipokines also leading to insulin resistance. We hypothesize that insulin resistance and adipokine dysbalance increase the severity of obesity subsequently aggravating alteration of adipose tissue trace element balance. Single indications of high relative adipose tissue trace element content, decreased Cr, V, and Zn content in obese adipose tissue, and tight association between fat tissue chromium, vanadium, and zinc levels and metabolic parameters in obesity may be useful for hypothesis validation. If our hypothesis will be confirmed by later studies, adipose tissue chromium, vanadium, and zinc content may be used as a prognostic biomarker of metabolic disturbances in obesity. Hypothetically, development and approbation of drugs increasing adipose tissue chromium, vanadium, and zinc content may help to achieve better metabolic control in obesity and obesity-related insulin resistance. However, stronger basis is required to prove our hypothesis. In particular, future studies should investigate the influence of obesity severity of adipose tissue trace element content, estimate the association between adipose tissue metals and metabolic parameters, and highlight the mechanisms involved in these changes. Both in vivo and in vitro studies are required to support the hypothesis. (C) 2015 Elsevier Ltd. All rights reserved.
C1 [Tinkov, Alexey A.; Skalny, Anatoly V.] Yaroslavl State Univ, Lab Biotechnol & Appl Bioelementol, Yaroslavl 150000, Russia.
   [Tinkov, Alexey A.; Popova, Elizaveta V.; Nemereshina, Olga N.; Gatiatulina, Evgenia R.; Nikonorov, Alexandr A.] Orenburg State Med Univ, Dept Biochem, Orenburg 460000, Russia.
   [Sinitskii, Anton I.] South Ural State Med Univ, Pharmaceut Fac, Dept Chem, Chelyabinsk 453092, Russia.
   [Skalnaya, Margarita G.; Skalny, Anatoly V.] Orenburg State Univ, Inst Bioelementol, Russian Satellite Ctr Trace Element, Inst UNESCO, Orenburg 460352, Russia.
   [Tinkov, Alexey A.; Skalnaya, Margarita G.; Skalny, Anatoly V.; Nikonorov, Alexandr A.] ANO Ctr Biot Med, Russian Soc Trace Elements Med, Moscow 105064, Russia.
C3 Yaroslavl State University; South Ural State Medical University;
   Orenburg State University
RP Tinkov, AA (corresponding author), Yaroslavl State Univ, Lab Biotechnol & Appl Bioelementol, Sovetskaya St 14, Yaroslavl 150000, Russia.
EM tinkov.a.a@gmail.com
RI Skalny, Anatoly/J-3953-2019; Nikonorova, Eugenia/AAQ-5445-2020; Tinkov,
   Alexey/H-5842-2016; Sinitskii, Anton/D-6010-2014
OI Tinkov, Alexey/0000-0003-0348-6192; Popova,
   Elizabeth/0000-0001-6703-4756; Skalnaya, Margarita/0000-0003-1099-2560;
   Sinitskii, Anton/0000-0001-5687-3976; Nemereshina,
   Olga/0000-0001-5399-7498; Nikonorov, Alexandr/0000-0001-7214-8176;
   Skalny, Anatoly/0000-0001-7838-1366; Nikonorova,
   Eugenia/0000-0002-6360-2194
FU Russian Ministry of Education and Science [2014/258-544]
FX The work has been supported by the Russian Ministry of Education and
   Science within project No. 2014/258-544.
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NR 79
TC 30
Z9 32
U1 0
U2 32
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0306-9877
EI 1532-2777
J9 MED HYPOTHESES
JI Med. Hypotheses
PD SEP
PY 2015
VL 85
IS 3
BP 343
EP 347
DI 10.1016/j.mehy.2015.06.005
PG 5
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA CQ8OP
UT WOS:000360868100021
PM 26112161
DA 2025-06-11
ER

PT J
AU Salomao, R
   Assis, V
   Neto, IVD
   Petriz, B
   Babault, N
   Durigan, JLQ
   Marqueti, RD
AF Salomao, Rebecca
   Assis, Victoria
   Neto, Ivo Vieira de Sousa
   Petriz, Bernardo
   Babault, Nicolas
   Durigan, Joao Luiz Quaglioti
   Marqueti, Rita de Cassia
TI Involvement of Matrix Metalloproteinases in COVID-19: Molecular Targets,
   Mechanisms, and Insights for Therapeutic Interventions
SO BIOLOGY-BASEL
LA English
DT Article
DE extracellular compartment; biomarker; inflammation; diseases;
   SARS-CoV-2; metallopeptidases
ID ISCHEMIA-REPERFUSION INJURY; TRANSFER-RNA SYNTHETASE; ISOLATED RAT
   HEARTS; MYOSIN LIGHT-CHAIN; EXTRACELLULAR-MATRIX; TISSUE INHIBITORS;
   OXIDATIVE STRESS; ALVEOLAR MACROPHAGES; METABOLIC SYNDROME;
   NERVOUS-SYSTEM
AB Simple Summary The costs worldwide of the coronavirus disease 2019 (COVID-19) have been tremendous. With millions of deaths in different countries, understanding biomarkers is essential to diminish the disease burden. For this purpose, a reflective understanding of the pathobiology of COVID-19 is required. During viral infection, some proteins require proteolytic activation and are involved in cell repair and maladaptive organ remodeling. This review summarizes the current findings on the role of increasing matrix metalloproteinases (MMPs) during acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection. COVID-19 patients present distinct complications that can be distinguished by MMP levels. MMPs in excess can generate tissue damage and aggravate the possible complications of COVID-19. MMPs participate in chronic inflammation, and their abnormal regulation is associated with human diseases. Interestingly, individuals with comorbidities or pathological conditions are more susceptible to increasing MMPs and to developing severe COVID-19 illnesses. Furthermore, MMP levels can predict the risk of in-hospital death by COVID-19, suggesting possible prognostic roles. Extensive knowledge of MMPs could provide novel perspectives on the symptoms, pathogenesis, and treatment of COVID-19. MMPs are enzymes involved in SARS-CoV-2 pathogenesis. Notably, the proteolytic activation of MMPs can occur through angiotensin II, immune cells, cytokines, and pro-oxidant agents. However, comprehensive information regarding the impact of MMPs in the different physiological systems with disease progression is not fully understood. In the current study, we review the recent biological advances in understanding the function of MMPs and examine time-course changes in MMPs during COVID-19. In addition, we explore the interplay between pre-existing comorbidities, disease severity, and MMPs. The reviewed studies showed increases in different MMP classes in the cerebrospinal fluid, lung, myocardium, peripheral blood cells, serum, and plasma in patients with COVID-19 compared to non-infected individuals. Individuals with arthritis, obesity, diabetes, hypertension, autoimmune diseases, and cancer had higher MMP levels when infected. Furthermore, this up-regulation may be associated with disease severity and the hospitalization period. Clarifying the molecular pathways and specific mechanisms that mediate MMP activity is important in developing optimized interventions to improve health and clinical outcomes during COVID-19. Furthermore, better knowledge of MMPs will likely provide possible pharmacological and non-pharmacological interventions. This relevant topic might add new concepts and implications for public health in the near future.
C1 [Salomao, Rebecca; Marqueti, Rita de Cassia] Univ Brasilia, Fac Ceilandia, Postgrad Program Hlth & Sci & Technol, Lab Mol Anal, BR-72220275 Brasilia, DF, Brazil.
   [Assis, Victoria; Durigan, Joao Luiz Quaglioti; Marqueti, Rita de Cassia] Univ Brasilia, Fac Ceilandia, Postgrad Program Rehabil Sci, Lab Mol Anal, BR-72220275 Brasilia, DF, Brazil.
   [Neto, Ivo Vieira de Sousa] Univ Sao Paulo, Sch Phys Educ & Sport Ribeirao Preto, BR-14040907 Ribeirao Preto, SP, Brazil.
   [Petriz, Bernardo] Univ Catolica Brasilia, Grad Program Genom Sci & Biotechnol, BR-71966700 Brasilia, DF, Brazil.
   [Petriz, Bernardo] Univ Ctr UDF, Lab Exercise Mol Physiol, BR-71966900 Brasilia, DF, Brazil.
   [Babault, Nicolas] Univ Bourgogne, INSERM, UMR1093, CAPS,UFR Sci Sport, F-21000 Dijon, France.
   [Babault, Nicolas] Univ Bourgogne, Ctr Expertise Performance, UFR Sci Sport, F-21000 Dijon, France.
C3 Universidade de Brasilia; Universidade de Brasilia; Universidade de Sao
   Paulo; Universidade Catolica de Brasilia; Centro Universitario do
   Distrito Federal; Institut National de la Sante et de la Recherche
   Medicale (Inserm); Universite Bourgogne Europe; Universite Bourgogne
   Europe
RP Salomao, R; Marqueti, RD (corresponding author), Univ Brasilia, Fac Ceilandia, Postgrad Program Hlth & Sci & Technol, Lab Mol Anal, BR-72220275 Brasilia, DF, Brazil.; Marqueti, RD (corresponding author), Univ Brasilia, Fac Ceilandia, Postgrad Program Rehabil Sci, Lab Mol Anal, BR-72220275 Brasilia, DF, Brazil.
EM rebecca.salomao@hotmail.com; vicassis.assis@gmail.com;
   ivoneto04@hotmail.com; bernardopetriz@gmail.com;
   nicolas.babault@u-bourgogne.fr; joaodurigan@gmail.com; marqueti@unb.br
RI SALOMÃO, REBECCA/JXL-9166-2024; de Sousa Neto, Ivo/F-6965-2018; Babault,
   Nicolas/D-7541-2013; Petriz, Bernardo/E-2343-2015; Marqueti, Rita de
   Cassia/D-1622-2012; Durigan, Joao/D-1110-2012
OI Vieira de Sousa Neto, Ivo/0000-0002-1479-5866; Babault,
   Nicolas/0000-0001-6563-503X; Petriz, Bernardo/0000-0002-3841-7616;
   Marqueti, Rita de Cassia/0000-0001-9126-3882; Salomao,
   Rebecca/0000-0002-1200-0513; Durigan, Joao/0000-0002-7511-5289
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NR 237
TC 15
Z9 16
U1 0
U2 7
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2079-7737
J9 BIOLOGY-BASEL
JI Biology-Basel
PD JUN
PY 2023
VL 12
IS 6
AR 843
DI 10.3390/biology12060843
PG 32
WC Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics
GA K1HR6
UT WOS:001014030000001
PM 37372128
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Abdullah, K
   AL-Habori, M
   Al-Eryani, E
AF Abdullah, Khaldoon
   Al-Habori, Molham
   Al-Eryani, Ekram
TI Ramadan Intermittent Fasting Affects Adipokines and Leptin/Adiponectin
   Ratio in Type 2 Diabetes Mellitus and Their First-Degree Relatives
SO BIOMED RESEARCH INTERNATIONAL
LA English
DT Article
ID BODY-COMPOSITION; BIOCHEMICAL PARAMETERS; GLYCEMIC CONTROL; LIPID
   PROFILE; INSULIN-RESISTANCE; ADIPONECTIN LEVELS; OXIDATIVE STRESS; SERUM
   LEPTIN; HS-CRP; HEALTHY
AB Background. In view of the association of Ramadan intermittent fasting with profound changes in lifestyle both in nondiabetic and diabetic patients, the aim of this study was to investigate the effect of Ramadan fasting on adiponectin, leptin and leptin to adiponectin ratio (LAR), growth hormone (GH), human-sensitive C-reactive protein (hs-CRP), and diabetic and metabolic syndrome factors in patients with Type 2 Diabetes Mellitus (Type 2 DM), their first-degree relatives (FDRs), and healthy controls.Methods. This cohort study involved 98 Yemeni male subjects aged 30-70 years old: 30 Type 2 DM, 37 FDRs of Type 2 diabetic patients, and 31 healthy control subjects. Subjects' body mass index (BMI), waist circumference (WC), and blood pressure (BP) were measured, and venous blood samples were collected twice: the first samples were collected a couple of days prior to Ramadan fasting (baseline) and the second samples after 3 weeks of fasting.Results. Ramadan fasting did not affect BMI, WC, and BP in Type 2 DM and their FDRs with respect to the baseline levels prior to Ramadan, whereas triglyceride and cholesterol were borderline significantly decreased in Type 2 DM with no effect in FDRs. Fasting blood glucose was not affected in Type 2 DM but was significantly increased in FDRs and control groups, whereas glycated haemoglobin (HbA1c) was slightly decreased in Type 2 DM, FDRs, and healthy controls. C-peptide, insulin, and insulin resistance (HOMA-IR) were significantly increased in Type 2 DM and FDRs, with no effect in the control group, whereas beta-cell function (HOMA-beta) was significantly decreased in FDRs and controls with no change in Type 2 DM. Ramadan fasting significantly decreased GH in both FDRs and control groups, and significantly increased hs-CRP in the control with no effect in Type 2 DM and FDRs. Adiponectin was significantly decreased, and leptin and LAR were significantly increased in Type 2 DM, FDRs, and control groups.Conclusion. Ramadan intermittent fasting decreased adiponectin and increased leptin, LAR, insulin, and insulin resistance in both Type 2 DM and FDRs as well as decreased GH in both FDRs and healthy controls and increased hs-CRP in healthy controls. Moreover, Ramadan intermittent fasting neither worsens a patient's glycemic parameters nor improves it, with the exception of a slight improvement in HbA1c in Type 2 DM, FDRs, and healthy controls.
C1 [Abdullah, Khaldoon; Al-Habori, Molham; Al-Eryani, Ekram] Univ Sanaa, Dept Biochem & Mol Biol, Fac Med & Hlth Sci, Sanaa, Yemen.
RP AL-Habori, M (corresponding author), Univ Sanaa, Dept Biochem & Mol Biol, Fac Med & Hlth Sci, Sanaa, Yemen.
EM sadaiqkhaldoon@gmail.com; malhabori@hotmail.com;
   heartcarebiolab@gmail.com
OI Abdullah, khaldoon Sadiq Ahmed/0000-0001-9980-3724
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NR 86
TC 11
Z9 11
U1 3
U2 24
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2314-6133
EI 2314-6141
J9 BIOMED RES INT
JI Biomed Res. Int.
PD JUL 28
PY 2020
VL 2020
AR 1281792
DI 10.1155/2020/1281792
PG 12
WC Biotechnology & Applied Microbiology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Research & Experimental Medicine
GA NC7AV
UT WOS:000561369000004
PM 32775407
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Tarantino, G
   Scopacasa, F
   Colao, A
   Capone, D
   Tarantino, M
   Grimaldi, E
   Savastano, S
AF Tarantino, Giovanni
   Scopacasa, Francesco
   Colao, Annamaria
   Capone, Domenico
   Tarantino, Marianna
   Grimaldi, Ernesto
   Savastano, Silvia
TI Serum Bcl-2 concentrations in overweight-obese subjects with
   nonalcoholic fatty liver disease
SO WORLD JOURNAL OF GASTROENTEROLOGY
LA English
DT Article
DE Bcl-2; Nonalcoholic fatty liver disease; Metabolically unhealthy
   overweight/obese
ID GROWTH-FACTOR-I; CYTOCHROME-C RELEASE; METABOLIC SYNDROME; OXIDATIVE
   STRESS; SOLUBLE FAS; URIC-ACID; APOPTOSIS; EXPRESSION; STEATOHEPATITIS;
   ACTIVATION
AB AIM: To shed some light on the relationship between anti-apoptotic serum Bcl-2 concentrations and metabolic status, anthropometric parameters, inflammation indices, and non-alcoholic fatty liver disease severity were investigated in 43 young individuals with fatty liver (FL) and 41 with nonalcoholic steatohepatitis (NASH).
   METHODS: Circulating levels of Bcl-2 were detected in 84 patients with ultrasonographic findings of "bright liver" and/or hyper-transaminasemia of unknown origin and/or increase in gamma-glutamyl-transpeptidase (gamma-GT) strictly in the absence of other acute or chronic liver disease, whose age was not advanced, who gave consent to liver biopsy and were then divided on the basis of the histological results into two groups (43 with FL and 41 with NASH). Twenty lean subjects, apparently healthy and young, were chosen as controls.
   RESULTS: Serum Bcl-2 concentrations were significantly higher in the FL group than in the NASH group. Insulin resistance and gamma-GT activity were significantly higher in NASH subjects. Apoptotic hepatocytes were significantly more numerous in NASH patients. NASH patients presented with larger spleens and augmented C-reactive protein (CRP) concentrations than healthy subjects. Steatosis grade at histology was similar in both NASH and FL populations. The number of apoptotic cells was significantly related to anti-apoptotic Bcl-2 protein values in FL patients. Bcl-2 serum levels positively correlated to body mass index (BMI) values (P <= 0.0001) but not to age of the population. Triglycerides/HDL ratio correlated well to waist circumference in males (P = 0.0008). gamma-GT activity was associated with homeostatic metabolic assessment (HOMA) (P = 0.0003) and with serum ferritin (P = 0.02). Bcl-2 concentrations were not related to either spleen size or CRP values. NASH patients presented a weak negative correlation between lobular inflammation and Bcl-2 levels. A prediction by low values of serum Bcl-2 towards a greater presence of metabolically unhealthy overweight/obese patients (MUOs) was evidenced. HOMA, BMI and uric acid, in that sequence, best predicted serum Bcl-2 concentrations.
   CONCLUSION: MUOs could be detected by Bcl-2 levels. By favoring the life span of hepatocytes, and enhancing triglyceride formation, the anti-apoptotic process inhibits free fatty acids toxicity in FL. (C) 2011 Baishideng. All rights reserved.
C1 [Tarantino, Giovanni] Federico II Univ Med Sch Naples, Dept Clin & Expt Med, I-80131 Naples, Italy.
   [Scopacasa, Francesco; Grimaldi, Ernesto] Federico II Univ Med Sch Naples, Dept Biochem & Med Biotechnol, I-80131 Naples, Italy.
   [Colao, Annamaria; Savastano, Silvia] Federico II Univ Med Sch Naples, Dept Mol & Clin Endocrinol & Oncol, Endocrinol Unit, I-80131 Naples, Italy.
   [Capone, Domenico] Federico II Univ Med Sch Naples, Dept Neurosci, Clin Pharmacol Unit, I-80131 Naples, Italy.
   [Tarantino, Marianna] Federico II Univ Med Sch Naples, Dept Biomorphol & Funct Sci, I-80131 Naples, Italy.
C3 University of Naples Federico II; University of Naples Federico II;
   University of Naples Federico II; University of Naples Federico II;
   University of Naples Federico II
RP Tarantino, G (corresponding author), Federico II Univ Med Sch Naples, Dept Clin & Expt Med, Via Sergio Pansini 5, I-80131 Naples, Italy.
EM tarantin@unina.it
RI Tarantino, Giovanni/AAW-2007-2021; Colao, Annamaria/A-7671-2011;
   Savastano, Silvia/K-6546-2016
OI Savastano, Silvia/0000-0002-3211-4307
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NR 37
TC 67
Z9 69
U1 0
U2 3
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 7041 Koll Center Parkway, Suite 160, PLEASANTON, CA, UNITED STATES
SN 1007-9327
EI 2219-2840
J9 WORLD J GASTROENTERO
JI World J. Gastroenterol.
PD DEC 28
PY 2011
VL 17
IS 48
BP 5280
EP 5288
DI 10.3748/wjg.v17.i48.5280
PG 9
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 871MI
UT WOS:000298741800007
PM 22219597
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Campbell, JE
   Király, MA
   Atkinson, DJ
   D'souza, AM
   Vranic, M
   Riddell, MC
AF Campbell, Jonathan E.
   Kiraly, Michael A.
   Atkinson, Daniel J.
   D'souza, Anna M.
   Vranic, Mladen
   Riddell, Michael C.
TI Regular exercise prevents the development of hyperglucocorticoidemia via
   adaptations in the brain and adrenal glands in male Zucker diabetic
   fatty rats
SO AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE
   PHYSIOLOGY
LA English
DT Article
DE glucocorticoid; stress; hippocampus; type 2 diabetes; wheel running
ID 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1; METABOLIC SYNDROME; ZDF
   RATS; INSULIN-RESISTANCE; SKELETAL-MUSCLE; TRANSGENIC MICE;
   ADIPOSE-TISSUE; FOOD-INTAKE; PITUITARY; HYPERGLYCEMIA
AB Campbell JE, Kiraly MA, Atkinson DJ, D'Souza AM, Vranic M, Riddell MC. Regular exercise prevents the development of hyperglucocorticoidemia via adaptations in the brain and adrenal glands in male Zucker diabetic fatty rats. Am J Physiol Regul Integr Comp Physiol 299: R168-R176, 2010. First published April 14, 2010; doi:10.1152/ajpregu.00155.2010.-We determined the effects of voluntary wheel running on the hypothalamic-pituitary-adrenal (HPA) axis, and the peripheral determinants of glucocorticoids action, in male Zucker diabetic fatty (ZDF) rats. Six-week-old euglycemic ZDF rats were divided into Basal, Sedentary, and Exercise groups (n = 8-9 per group). Basal animals were immediately killed, whereas Sedentary and Exercising rats were monitored for 10 wk. Basal (i.e., similar to 0900 AM in the resting state) glucocorticoid levels increased 2.3-fold by week 3 in Sedentary rats where they remained elevated for the duration of the study. After an initial elevation in basal glucocorticoid levels at week 1, Exercise rats maintained low glucocorticoid levels from week 3 through week 10. Hyperglycemia was evident in Sedentary animals by week 7, whereas Exercising animals maintained euglycemia throughout. At the time of death, the Sedentary group had similar to 40% lower glucocorticoid receptor (GR) content in the hippocampus, compared with the Basal and Exercise groups (P < 0.05), suggesting that the former group had impaired negative feedback regulation of the HPA axis. Both Sedentary and Exercise groups had elevated ACTH compared with Basal rats, indicating that central drive of the axis was similar between groups. However, Sedentary, but not Exercise, animals had elevated adrenal ACTH receptor and steroidogenic acute regulatory protein content compared with the Basal animals, suggesting that regular exercise protects against elevations in glucocorticoids by a downregulation of adrenal sensitivity to ACTH. GR and 11 beta-hydroxysteroid dehydrogenase type 1 content in skeletal muscle and liver were similar between groups, however, GR content in adipose tissue was elevated in the Sedentary groups compared with the Basal and Exercise (P < 0.05) groups. Thus, the gradual elevations in glucocorticoid levels associated with the development of insulin resistance in male ZDF rats can be prevented with regular exercise, likely because of adaptations that occur primarily in the adrenal glands.
C1 [Campbell, Jonathan E.; Atkinson, Daniel J.; D'souza, Anna M.; Riddell, Michael C.] York Univ, Fac Hlth, Muscle Hlth Res Ctr, Sch Kinesiol & Hlth Sci, Toronto, ON M3J 1P3, Canada.
   [Kiraly, Michael A.; Vranic, Mladen] Univ Toronto, Dept Physiol, Toronto, ON, Canada.
   [Kiraly, Michael A.; Vranic, Mladen] Univ Toronto, Dept Med, Toronto, ON, Canada.
C3 York University - Canada; University of Toronto; University of Toronto
RP Riddell, MC (corresponding author), York Univ, Fac Hlth, Muscle Hlth Res Ctr, Sch Kinesiol & Hlth Sci, 4700 Keele St, Toronto, ON M3J 1P3, Canada.
EM mriddell@yorku.ca
OI Campbell, Jonathan/0000-0001-8223-1600
FU Canadian Diabetes Association [09-2904]; Natural Science and Engineering
   Research Council of Canada [261306]; Canadian Institutes of Health
   Research
FX This work was supported by Canadian Diabetes Association Grant 09-2904
   (to M.C. Riddell and M. Vranic) and the Natural Science and Engineering
   Research Council of Canada Grant 261306 (to M.C. Riddell). J.E. Campbell
   is a recipient of the Canadian Institutes of Health Research-Graduate
   Scholarship Doctoral Award.
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NR 42
TC 44
Z9 52
U1 0
U2 10
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0363-6119
EI 1522-1490
J9 AM J PHYSIOL-REG I
JI Am. J. Physiol.-Regul. Integr. Comp. Physiol.
PD JUL
PY 2010
VL 299
IS 1
BP R168
EP R176
DI 10.1152/ajpregu.00155.2010
PG 9
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA 616FR
UT WOS:000279194900017
PM 20393161
DA 2025-06-11
ER

PT J
AU Urraza-Robledo, AI
   Giralt, M
   González-Galarza, FF
   Villarroya, F
   Pérez, AAM
   Flores, PR
   Pérez, MEG
   Domingo, P
   López-Márquez, FC
AF Ivonne Urraza-Robledo, Arguine
   Giralt, Marta
   Francisco Gonzalez-Galarza, Faviel
   Villarroya, Francesc
   Miranda Perez, Alberto Alejandro
   Ruiz Flores, Pablo
   Gutierrez Perez, Maria Elena
   Domingo, Pere
   Carlos Lopez-Marquez, Francisco
TI FGF21 serum levels are related to insulin resistance, metabolic changes
   and obesity in Mexican people living with HIV (PLWH)
SO PLOS ONE
LA English
DT Article
ID GROWTH-FACTOR 21; ANTIRETROVIRAL THERAPY; LIPODYSTROPHY; EXPRESSION;
   FGF-21
AB Background Antiretroviral therapy has significantly improved prognosis in treatment against HIV infection, however, prolonged exposure is associated to cardiovascular diseases, lipodystrophy, type 2 diabetes, insulin resistance, metabolic alteration, as obesity which includes the accumulation of oxidative stress in adipose tissue. FGF21 is a peptide hormone that is known to regulate glucose and lipid metabolism. FGF21 is expressed and secreted primarily in the liver and adipose tissue, promoting oxidation of glucose/fatty acids and insulin sensitivity. Alterations in FGF21 may be associated with the development of insulin resistance, metabolic syndrome and cardiovascular disease. We hypothesized that FGF21 protein levels are associated with metabolic abnormalities, placing special attention to the alterations in relation to the concurrence of overweight/obesity in people living with HIV (PLWH).
   Design Serum FGF21 was analyzed in 241 subjects, 160 PLWH and 81 unrelated HIV-uninfected subjects as a control group. Clinical records were consulted to obtain CD4+ cell counting and number of viral RNA copies. Serum FGF21 levels were tested for correlation with anthropometric and metabolic parameters; glucose, cholesterol, HDL, LDL, VLDL, triglycerides, insulin and indexes of atherogenesis and insulin resistance (HOMA).
   Results The participants were classified into four groups: (i) PLWH with normal weight, (ii) PLWH with overweight/obesity, (iii) HIV-uninfected with normal weight, and (iv) HIV-uninfected with overweight/obesity. Insulin levels were higher in normal-weight PLWH than in the HIV-uninfected group but not statistically significant, however, for the overweight/obesity PLWH group, insulin levels were significantly higher in comparison with the other three groups (p<0.0001). For FGF21, serum levels were slightly higher in the overweight/obesity groups in both patients and controls. In HIV-infected subjects, FGF21 levels showed a strong positive correlation with triglycerides, insulin levels and insulin resistance with a p-value <0.0001. In the seronegative group, FGF21 was only correlated with weight and waist circumference, showing an important association of FGF21 levels with the degree of obesity of the individuals.
   Conclusion Insulin resistance and FGF21 elevations were observed in overweight-obese PLWH. FGF21 elevation could be viewed as a compensation mechanism as, in the control group, FGF21 correlations appeared to be confined to weight and waist circumference. This can be explained based on the action of FGF21 promoting the uptake of glucose in adipose tissue. In PLWH, FGF21 was low, possibly as a result of a change in adiposity leading to a metabolic disruption.
C1 [Ivonne Urraza-Robledo, Arguine] Autonomous Univ Coahuila IMSS, Med Sch, Ctr Biomed Res, Torreon, Mexico.
   [Ivonne Urraza-Robledo, Arguine] Mexican Social Secur Inst, High Specialty Med Unit UMAE 71, Mexico City, DF, Mexico.
   [Giralt, Marta; Villarroya, Francesc] Univ Barcelona, CIBER Fisiopatol Obesidad & Nutr, Dept Bioquim & Biomed Mol, Barcelona, Spain.
   [Giralt, Marta; Villarroya, Francesc] Univ Barcelona, CIBER Fisiopatol Obesidad & Nutr, Inst Biomed IBUB, Barcelona, Spain.
   [Francisco Gonzalez-Galarza, Faviel; Ruiz Flores, Pablo; Carlos Lopez-Marquez, Francisco] Autonomous Univ Coahuila, Fac Med, Ctr Biomed Res, Torreon, Mexico.
   [Miranda Perez, Alberto Alejandro; Gutierrez Perez, Maria Elena] Autonomous Univ Coahuila, Med Sch, Biomed Res Ctr, Torreon, Mexico.
   [Domingo, Pere] Hosp Santa Creu & Sant Pau, Inst Recerca, Dept Infect Dis, Barcelona, Spain.
C3 Instituto Mexicano del Seguro Social; CIBER - Centro de Investigacion
   Biomedica en Red; CIBEROBN; University of Barcelona; CIBER - Centro de
   Investigacion Biomedica en Red; CIBEROBN; University of Barcelona;
   Universidad Autonoma de Coahuila; Universidad Autonoma de Coahuila;
   Autonomous University of Barcelona; Hospital Universitari Vall d'Hebron;
   Vall d'Hebron Institut de Recerca (VHIR); Hospital of Santa Creu i Sant
   Pau
RP López-Márquez, FC (corresponding author), Autonomous Univ Coahuila, Fac Med, Ctr Biomed Res, Torreon, Mexico.
EM francisco.lopez@uadec.edu.mx
RI Domingo, Pere/CAH-9641-2022; Villarroya, Francesc/K-4357-2014; Giralt,
   Marta/A-4756-2013
OI LOPEZ MARQUEZ, FRANCISCO CARLOS/0000-0003-2939-7411; Giralt,
   Marta/0000-0001-7968-4190
FU State Council of Science and Technology (FONCYT) [COAH-2019-C13-C054];
   Instituto de Salud Carlos III, Spain [PI17/00498, PI17/00420]; European
   Regional Development Fund
FX We received funding from The State Council of Science and Technology
   (FONCYT) COAH-2019-C13-C054, for the purchase of reagents used in this
   project, in addition to having a grant from supported by PI17/00498 &
   PI17/00420 from the Instituto de Salud Carlos III, Spain, co-financed by
   the European Regional Development Fund.
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NR 37
TC 7
Z9 7
U1 0
U2 2
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAY 21
PY 2021
VL 16
IS 5
AR e0252144
DI 10.1371/journal.pone.0252144
PG 12
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA SW6OD
UT WOS:000664632300055
PM 34019585
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Meyer, MF
   Lieps, D
   Schatz, H
   Klein, HH
   Pfohl, M
AF Meyer, M. F.
   Lieps, D.
   Schatz, H.
   Klein, H. H.
   Pfohl, M.
TI Influence of the duration of type 2 diabetes on early functional and
   morphological markers of atherosclerosis compared to the impact of
   coexisting classic cardiovascular risk factors
SO EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
LA English
DT Article
DE diabetes duration; endothelial dysfunction; endothelium-dependent
   vasodilation; endothelium-independent vasodilation; flow-mediated
   dilation; intima-media thickness; type 2 diabetes
ID PROTEIN-KINASE-C; HUMAN-ENDOTHELIAL-CELLS; INTIMA-MEDIA THICKNESS;
   CORONARY-HEART-DISEASE; NITRIC-OXIDE; INSULIN-RESISTANCE;
   CIGARETTE-SMOKING; OXIDATIVE STRESS; VASCULAR COMPLICATIONS; ADVANCED
   GLYCATION
AB Aim: The increased incidence of atherosclerotic macrovascular disease in type 2 diabetic patients is associated both with diabetes specific factors and coexisting classic cardiovascular risk factors as components of the metabolic syndrome. The aim of this study was to investigate the association between the duration of diabetes and early functional and morphological markers of atherosclerosis compared to the impact of coexisting cardiovascular risk factors such as hypertension, dyslipoproteinemia and cigarette smoking.
   Methods: 63 type 2 diabetic patients and 25 non-diabetic control subjects were investigated. Lumen diameter of the brachial artery was measured by high-resolution ultrasound at rest and after 5-min suprasystolic arterial compression. Endothelium-independent dilatation of the brachial artery was measured 4 min after sublingual administration of 400 mu g of glycerol trinitrate (GTN). Percentage change of arterial lumen diameter during reactive hyperemia (FMD%) and after GTN administration (GTN%) relative to the baseline measurements were calculated. The intima-media thickness (IMT) of the common carotid artery was measured bilaterally and averages were calculated.
   Results: FMD%(3.8 +/- 0.8%vs.6.9 +/- 0.9%;p<0.01) and GTN% (5.6 +/- 0.7% vs. 14.9 +/- 1.7%; p<0.01) were reduced in the diabetic patients compared to their control subjects. IMT was increased in diabetic patients compared to their controls (0.82 +/- 0.02mm vs. 0.62 +/- 0.02mm; p<0.01). The age-adjusted diabetes duration was inversely related to FMD% (r=-0.27; p=0.016). On multiple regression analysis including packyears, hypertension, hypercholesterolemia, and hypertriglyceridemia, only diabetes duration remained a significant independent determinant of FMD. GTN% and IMT were not associated with diabetes duration, packyears, hypertension, hypercholesterolemia, and hypertriglyceridemia when all variables were taken into account.
   Conclusion: The present data lend support to the suggestion that diabetic specific factors compared to coexisting cardiovascular risk factors such as hypertension, hyperlipoproteinemia, and smoking are of major importance for the pathogenesis of endothelial dysfunction in type 2 diabetes, because only the diabetes duration was shown to be related to endothelium-dependent vasodilation when all variables were taken into account.
C1 [Meyer, M. F.; Schatz, H.; Klein, H. H.] Ruhr Univ Bochum, Dept Internal Med, Univ Clin Bergmannsheil, D-44789 Bochum, Germany.
   [Lieps, D.] Univ Med Berlin, Dept Dermatol & Venerol, Vivantes Klinikum Neukolln, Acad Teaching Hosp Charite, Berlin, Germany.
   [Pfohl, M.] Bethesda Hosp, Dept Internal Med, Duisburg, Germany.
C3 Ruhr University Bochum; VIivantes Klinikum Neukolln; Berlin Institute of
   Health; Free University of Berlin; Humboldt University of Berlin;
   Charite Universitatsmedizin Berlin
RP Meyer, MF (corresponding author), Ruhr Univ Bochum, Dept Internal Med, Univ Clin Bergmannsheil, Burkle Camp Pl 1, D-44789 Bochum, Germany.
EM martin.meyer-2@rub.de
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NR 49
TC 8
Z9 8
U1 0
U2 2
PU JOHANN AMBROSIUS BARTH VERLAG MEDIZINVERLAGE HEIDELBERG GMBH
PI STUTTGART
PA RUEDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0947-7349
J9 EXP CLIN ENDOCR DIAB
JI Exp. Clin. Endocrinol. Diabet.
PD MAY
PY 2008
VL 116
IS 5
BP 298
EP 304
DI 10.1055/s-2008-1042404
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 310MK
UT WOS:000256533500009
PM 18273756
DA 2025-06-11
ER

PT J
AU Frey, FJ
   Odermatt, A
   Frey, BM
AF Frey, FJ
   Odermatt, A
   Frey, BM
TI Glucocorticoid-mediated mineralocorticoid receptor activation and
   hypertension
SO CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION
LA English
DT Review
DE aldosterone; cortisol; 11 beta-hydroxysteroid dehydrogenase;
   hypertension; liver cirrhosis; mineralocorticoid receptor; nephrotic
   syndrome; PPAR-gamma; salt sensitivity
ID 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-2; BLOOD-PRESSURE; PPAR-GAMMA;
   SALT-SENSITIVITY; DOWN-REGULATION; CARDIAC FIBROSIS; REDUCED ACTIVITY;
   GENE-EXPRESSION; BINDING DOMAIN; ALDOSTERONE
AB Purpose of review
   Traditionally, the mineralocorticoid receptor was thought to be activated by the mineralocorticoid hormone aldosterone, and to exhibit its main action on epithelia by promoting renal sodium retention, potassium excretion and inducing hypertension upon excessive activation. Recently, evidence appeared that mineralocorticoid receptors are expressed in nonepithelial cells and activated by endogenous glucocorticoids including cortisol. Therefore, the prereceptor regulation of cortisol access to the mineralocorticoid receptors by 11beta-hydroxysteroid dehydrogenase enzymes (11beta-HSDs), a mechanism absent in most nonepithelial cells, appears to be relevant for disease states with cortisol-induced mineralocorticoid action. The present review focuses on direct and indirect effects attributable to mineralocorticoid receptor activation by glucocorticoids.
   Recent findings
   The determination of the intracellular topology of 11beta-HSD 1, facing the endoplasmic reticulum lumen, and 11beta-HSD2, facing the cytoplasm, suggests that 11beta-HSD1 acts as a prereceptor mechanism in the local activation of glucocorticoid receptors, whereas 11beta-HSD2 controls mineralocorticoid receptors by interacting with the receptor in the absence of aldosterone. Downregulation of 11beta-HSD2 was observed with various stimuli including hypoxia, shear stress, angiotensin 11 and tumor necrosis factor a. The corresponding signal transcription pathways and some relevant transcription factors have been identified. Renal sodium retention in liver cirrhosis, nephrotic syndrome and hypoxia have been linked to 11beta-HSD2 reduced activity. Overexpression of 11beta-HSD1 specifically in adipose tissue in mice caused central obesity, a metabolic syndrome and hypertension due to increased intracellular cortisol concentrations. Peroxisome proliferator-activated receptor gamma agonists reduce 11beta-HSD1 activity and diminish the intracellular availability of cortisol, an effect accompanied by a decline in blood pressure. Three individuals with loss-of-function mutations of peroxisome proliferator-activated receptor developed early hypertension. A potential mechanism might be glucocorticoid dependent mineralocorticoid receptor-mediated downregulation of endothelial nitric oxide synthase.
   Summary
   Recently, mineralocorticoid receptor antagonists have been used in the randomized aldactone evaluation study (RALES) with spironolactone, the eplerenone post-AMI heart failure efficacy and survival study (EPHESUS), and in severe and postmyocardial infarct heart failure, respectively. These investigations cannot be understood on the basis of the present physiological knowledge and underscore the relevance of focusing on mineralocorticoid receptor activation by ligands other than aldosterone.
C1 Univ Bern, Inselspital, Dept Hypertens & Nephrol, CH-3010 Bern, Switzerland.
C3 University of Bern; University Hospital of Bern
RP Univ Bern, Inselspital, Dept Hypertens & Nephrol, Freiburgstr 10, CH-3010 Bern, Switzerland.
EM felix.frey@insel.ch
OI Odermatt, Alex/0000-0002-6820-2712
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NR 81
TC 114
Z9 130
U1 0
U2 18
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1062-4821
EI 1473-6543
J9 CURR OPIN NEPHROL HY
JI Curr. Opin. Nephrol. Hypertens.
PD JUL
PY 2004
VL 13
IS 4
BP 451
EP 458
DI 10.1097/01.mnh.0000133976.32559.b0
PG 8
WC Urology & Nephrology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology; Cardiovascular System & Cardiology
GA 836BV
UT WOS:000222531000008
PM 15199296
DA 2025-06-11
ER

PT J
AU Shi, YJ
   Liu, CQ
   Xiong, S
   Yang, L
   Yang, CG
   Qiao, WB
   Liu, YC
   Liu, SY
   Liu, JA
   Dong, GJ
AF Shi, Yujiao
   Liu, Chunqiu
   Xiong, Shuang
   Yang, Ling
   Yang, Chenguang
   Qiao, Wenbo
   Liu, Yongcheng
   Liu, Siyu
   Liu, Jiangang
   Dong, Guoju
TI Ling-Gui-Qi-Hua formula alleviates left ventricular myocardial fibrosis
   in rats with heart failure with preserved ejection fraction by blocking
   the transforming growth factor-81/Smads signaling pathway
SO JOURNAL OF ETHNOPHARMACOLOGY
LA English
DT Article
DE Heart failure with preserved ejection fraction; Ling-qui-qi-hua
   decoction; Liquid chromatography-mass spectrometry; Left ventricular
   fibrosis; Left ventricular remodeling; TGF-81; Smads signaling pathway
ID GALLIC ACID; PORIA-COCOS; OXIDATIVE STRESS; PAEONIFLORIN; INFLAMMATION;
   POLYSACCHARIDES; QUANTIFICATION; DYSFUNCTION; EXTRACTION; MICE
AB Ethnopharmacological relevance: Ling-Qui-Qi-Hua (LGQH) decoction, composed of Poria cocos (Schw.) Wolf, Cinnamomum cassia (L.) J. Presl, Paeonia veitchii Lynch, and Atractylodes macrocephala Koidz., is a compound formula derived from Ling-Gui-Zhu-Gan decoction recorded in the Treatise on Febrile and Miscellaneous. It has shown cardioprotective effects on patients or rats with heart failure with preserved ejection fraction (HFpEF). Nevertheless, the active ingredients of LGQH and its anti-fibrotic mechanism remain unknown.Aim of the study: To determine the active ingredients in LGQH decoction and verify that LGQH decoction may inhibit left ventricular (LV) myocardial fibrosis in HFpEF rats by blocking the transforming growth factor-81 (TGF-81)/Smads signaling pathway from the perspective of animal experiments.Materials and methods: First, liquid chromatography-mass spectrometry (LC-MS) technology was used to identify active components in the LGQH decoction. Secondly, a rat model of the metabolic syndrome-associated HFpEF phenotype was established and subsequently received LGQH intervention. The mRNA and protein expression of targets in the TGF-81/Smads pathway were detected by quantitative real-time polymerase chain reaction and western blot analysis. Finally, molecular docking was conducted to examine the interactions between the active ingredients in the LGQH decoction and key proteins of the TGF-81/Smads pathways.Results: According to LC-MS analysis, the LGQH decoction contained 13 active ingredients. In animal experiments, LGQH attenuated LV hypertrophy, enlargement, and diastolic function in HEpEF rats. Mechanically, LGQH not only down-regulated TGF-81, Smad2, Smad3, Smad4, a-SMA, Coll I, and Coll III mRNA expressions and TGF-81, Smad2, Smad3, P-Smad2/Smad3, Smad4, a-SMA, and Coll I protein expressions, but also upregulated Smad7 mRNA and protein expressions, which ultimately led to myocardial fibrosis. Furthermore, molecular docking confirmed that 13 active ingredients in the LGQH decoction have excellent binding activities to the critical targets of the TGF-81/Smads pathway.Conclusion: LGQH is a modified herbal formulation with multiple active ingredients. It might alleviate LV remodeling and diastolic dysfunction and inhibit LV myocardial fibrosis by blocking TGF-81/Smads pathways in HFpEF rats.
C1 [Shi, Yujiao; Liu, Chunqiu; Xiong, Shuang; Yang, Chenguang; Qiao, Wenbo; Liu, Yongcheng; Liu, Siyu; Dong, Guoju] Chinese Acad Tradit Chinese Med, Xiyuan Hosp, Dept Cardiovasc Internal Med, Beijing 100091, Peoples R China.
   [Yang, Ling; Liu, Jiangang; Dong, Guoju] Chinese Acad Tradit Chinese Med, Xiyuan Hosp, Natl Clin Res Ctr Chinese Med Cardiol, Beijing 100091, Peoples R China.
C3 Xiyuan Hospital, CACMS; China Academy of Chinese Medical Sciences; China
   Academy of Chinese Medical Sciences; Xiyuan Hospital, CACMS
RP Dong, GJ (corresponding author), Chinese Acad Tradit Chinese Med, Xiyuan Hosp, Dept Cardiovasc Internal Med, Beijing 100091, Peoples R China.; Liu, JA; Dong, GJ (corresponding author), Chinese Acad Tradit Chinese Med, Xiyuan Hosp, Natl Clin Res Ctr Chinese Med Cardiol, Beijing 100091, Peoples R China.
EM liujiangang2002@sina.com; 13691393589@163.com
RI Yang, Chenguang/ABE-7755-2020; liu, chunqiu/MTD-7990-2025
OI Shi, Yujiao/0000-0002-3079-0459
FU National Natural Sci-ence Foundation of China [82074423]; Major
   Innovation Project of the China Academy of Traditional Chinese Medicine;
    [CI2021A00903]
FX (CI2021A00903) . This study was supported by grants from the National
   Natural Sci-ence Foundation of China (82074423) and the Major Innovation
   Project of the China Academy of Traditional Chinese Medicine
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NR 75
TC 9
Z9 10
U1 6
U2 24
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0378-8741
EI 1872-7573
J9 J ETHNOPHARMACOL
JI J. Ethnopharmacol.
PD DEC 5
PY 2023
VL 317
AR 116849
DI 10.1016/j.jep.2023.116849
EA JUL 2023
PG 14
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA N8OP7
UT WOS:001039546100001
PM 37385575
OA hybrid
DA 2025-06-11
ER

PT J
AU Chuang, CC
   Martinez, K
   Xie, GX
   Kennedy, A
   Bumrungpert, A
   Overman, A
   Jia, W
   McIntosh, MK
AF Chuang, Chia Chi
   Martinez, Kristina
   Xie, Guoxiang
   Kennedy, Arion
   Bumrungpert, Akkarach
   Overman, Angel
   Jia, Wei
   McIntosh, Michael K.
TI Quercetin is equally or more effective than resveratrol in attenuating
   tumor necrosis factor-α-mediated inflammation and insulin resistance in
   primary human adipocytes
SO AMERICAN JOURNAL OF CLINICAL NUTRITION
LA English
DT Article
ID NF-KAPPA-B; 3T3-L1 ADIPOCYTES; TNF-ALPHA; RECEPTOR SUBSTRATE-1; DIETARY
   POLYPHENOLS; METABOLIC SYNDROME; OXIDATIVE STRESS; PROTEIN-KINASES;
   ADIPOSE-TISSUE; GLUCOSE-UPTAKE
AB Background Quercetin and trans resveratrol (trans RSV) are plant polyphenols reported to reduce inflammation or insulin resistance associated with obesity Recently we showed that grape powder extract which contains quercetin and trans RSV attenuates markers of inflammation in human adipocytes and macrophages and insulin resistance in human adipocytes However we do not know how quercetin and trans RSV individually affected these outcomes
   Objective The aim of this study was to examine the extent to which quercetin and trans RSV prevented inflammation or insulin resistance in primary cultures of human adipocytes treated with tumor necrosis factor alpha (TNF alpha) an inflammatory cytokine elevated in the plasma and adipose tissue of obese diabetic individuals
   Design Cultures of human adipocytes were pretreated with quercetin and trans RSV followed by treatment with TNF alpha Subsequently gene and protein markers of inflammation and insulin resistance were measured
   Results Quercetin and to a lesser extent trans RSV attenuated the TNF a induced expression of inflammatory genes such as interleukin (IL) 6 IL I beta IL 8 and monocyte chemoattractant protein 1 (MCP I) and the secretion of IL 6 IL 8 and MCP 1 Quercetin attenuated TNF alpha-mediated phosphorylation of cxtracellular signal related kinase and c Jun NH2 terminal kinase whereas trans RSV attenuated only c Jun NH2 terminal kinase phosphorylation Querce tin and trans RSV attenuated TNF alpha-mediated phosphorylation of c Jun and degradation of inhibitory KB protein Quercenn but not trans RSV decreased TNF a induced nuclear factor kappa B transcnp tional activity Quercetin and trans RSV attenuated the TNF alpha-mediated suppression of peroxisome proliferator activated receptor y (PPAR gamma) and PPAR gamma target genes and of PPAR gamma protein concen trations and transcriptional activity Quercetin prevented the TNF alpha-mediated senne phosphorylation of insulin receptor substrate 1 and protein tyrosine phosphatase kappa B gene expression and the suppression of insulin stimulated glucose uptake whereas trans RSV prevented only the TNF alpha-mediated senne phosphorylation of insulin receptor substrate I
   Conclusion These data suggest that quercetin is equally or more effective than trans RSV in attenuating TNF alpha-mediated inflamma tion and insulin resistance in primary human adipocytes Am J Chn Ntttr 2010 92 1511-21
C1 [Chuang, Chia Chi; Martinez, Kristina; Kennedy, Arion; Overman, Angel; McIntosh, Michael K.] Univ N Carolina, Dept Nutr, Greensboro, NC 27402 USA.
   [Xie, Guoxiang; Jia, Wei] Univ N Carolina, Ctr Res Excellence Bioact Food Components, Kannapolis, NC USA.
   [Bumrungpert, Akkarach] Mahidol Univ, Fac Publ Hlth, Dept Nutr, Bangkok 10700, Thailand.
C3 University of North Carolina; University of North Carolina Greensboro;
   University of North Carolina; Mahidol University
RP McIntosh, MK (corresponding author), Univ N Carolina, Dept Nutr, 318 Stone Bldg,POB 26170, Greensboro, NC 27402 USA.
RI Jia, Wei/AAN-5102-2020; Xie, Guoxiang/F-3022-2016; Martinez-Guryn,
   Kristina/Y-9770-2019
OI Jia, Wei/0000-0002-3739-8994; Kennedy, Arion/0000-0002-8443-3131; Xie,
   Guoxiang/0000-0002-0951-4150; Martinez, Kristina/0000-0002-9676-0009;
   Chuang Key, Chia-Chi/0000-0003-0669-2936
FU WB Kellogg Institute for Food and Marketing; North Carolina Agricultural
   Research Service (NCARS) [02288]
FX Supported in part by a grant from the WB Kellogg Institute for Food and
   Marketing and the North Carolina Agricultural Research Service (NCARS
   02288)
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NR 55
TC 172
Z9 194
U1 0
U2 31
PU AMER SOC NUTRITION-ASN
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0002-9165
J9 AM J CLIN NUTR
JI Am. J. Clin. Nutr.
PD DEC
PY 2010
VL 92
IS 6
BP 1511
EP 1521
DI 10.3945/ajcn.2010.29807
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 690HM
UT WOS:000284993600031
PM 20943792
OA Bronze
DA 2025-06-11
ER

PT J
AU Sfayyih, HS
   Jewad, AM
   Khudhair, HA
AF Sfayyih, Hussein Saeed
   Jewad, Abdulkareem M.
   Khudhair, Hasan Abd Ali
TI Clinical significances of circulating serum fetuin-A, netrin-1, and
   α-hydroxybutyrate levels in type 2 diabetes mellitus patients with and
   without hypertension
SO ANAESTHESIA PAIN & INTENSIVE CARE
LA English
DT Article
DE Diabetes; Fetuin-A; Netrin-1; alpha-HB; HOMA-IR
ID INSULIN-RESISTANCE; METABOLIC SYNDROME; OXIDATIVE STRESS; PATHOGENESIS;
   OBESITY; MARKER; LIVER; RISK
AB Background & Objective: Type 2 diabetes (T2D) is a rising global health issue, with biomarkers such as fetuin-A (FetA), netrin-1 (NTN-1), and alpha-hydroxybutyrate (alpha-HB) showing potential for early diagnosis and management. These biomarkers can help predict T2D risk and understand insulin resistance (IR), emphasizing the need for further research. The current investigation evaluated the effectiveness of Fet-A, NTN-1, and, alpha-HB as novel biomarkers to diagnose T2D with hypertension. Methodology: A cross-sectional study was conducted from August to December 2023, involved 60 diabetic participants, which were divided into two groups: T2D without hypertension and T2D with hypertension. A third group consisted of 30 healthy controls (HC) for comparison. Serum samples were analyzed for fasting blood glucose (FBG) using the Roche/Cobas c111 system, as well as insulin, Fet-A, NTN-1, and alpha-HB levels using kits for the enzyme- linked immune-sorbent assay (ELISA). Descriptive statistics were used in the statistical package for social sciences (SPSS) for data analysis. Results: The study found significantly elevated Fet-A, NTN-1, and alpha-HB levels in T2D patients compared to HC, with no significant differences between T2D subgroups. Fetuin-A and alpha-HB showed non-significant correlations with FBG and homeostatic model assessment of IR (HOMA-IR) across all groups. NTN-1 positively correlated with FBG and HOMA-IR in T2D patients with hypertension. Conclusions: Elevated levels of fetuin-A and netrin-1, regardless of the presence of hypertension, are suggested by the study as possible biomarkers for the diagnosis of T2D. Netrin-1's significant correlation with HOMA-IR in hypertensive T2D patients underscores its utility in assessing insulin resistance severity. Although alphahydroxybutyrate levels were higher in T2D patients, their non-significant correlation with FBG and HOMA-IR requires further research. These biomarkers could aid in early diagnosis and disease monitoring for T2D management. Abbreviations: alpha-KB- alpha-ketobutyrate; ELISA- enzyme linked immune-sorbent assay; FA- fatty acids; FBG- fasting blood glucose; Fet-A- fetuin-A; HOMA-IR- homeostatic model assessment of IR; IR- insulin resistance; NAD- nicotinamide adenine dinucleotide; NADH- nicotinamide adenine dinucleotide hydrogen; ng- nanograms; NTN-1- netrin-1; PB- peripheral blood; pg- picogram; SPSS- Statistical Package for Social Sciences; T2D- Type-2 diabetes mellitus; alpha-HB- alpha-hydroxybutyrate
C1 [Sfayyih, Hussein Saeed; Jewad, Abdulkareem M.] Southern Tech Univ, Coll Hlth & Med Tech Al Basrah, Minist Higher Educ & Sci Res, Basra, Iraq.
   [Khudhair, Hasan Abd Ali] Southern Tech Univ, Al Nasiriyah Tech Inst, Minist Higher Educ & Sci Res, Basra, Iraq.
C3 Southern Technical University; Southern Technical University
RP Khudhair, HA (corresponding author), Southern Tech Univ, Al Nasiriyah Tech Inst, Minist Higher Educ & Sci Res, Basra, Iraq.
EM hsynalshwyly859@gmail.com; drkreem.mohammed@stu.edu.iq;
   hasanabdali89@stu.edu.iq
RI Khudhair, Hasan Abd Ali/ABD-1252-2020
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NR 46
TC 0
Z9 0
U1 1
U2 1
PU ANAESTHESIA PAIN & INTENSIVE CARE
PI ISLAMABAD
PA C/O TARIQ HAYAT KHAN, ED, 60-A, NAZIM-UD-DIN RD, ISLAMABAD, 00000,
   PAKISTAN
SN 1607-8322
EI 2220-5799
J9 ANAESTH PAIN INTENSI
JI Anaesth. Pain Intensive Care
PD OCT
PY 2024
VL 28
IS 5
BP 883
EP 893
DI 10.35975/apic.v28i5.2569
PG 11
WC Anesthesiology
WE Emerging Sources Citation Index (ESCI)
SC Anesthesiology
GA J4W0F
UT WOS:001337071800017
OA gold
DA 2025-06-11
ER

PT J
AU Aravindraj, R
   Renuka, P
   Vinodhini, VM
   Sundari, SM
AF Aravindraj, R.
   Renuka, P.
   Vinodhini, V. M.
   Sundari, S. N. Meenakshi
TI Circulating Chemerin Levels in Obese and Non- obese Individuals and Its
   Association With Obesity in Metabolic Dysfunction-Associated Fatty Liver
   Disease
SO CUREUS JOURNAL OF MEDICAL SCIENCE
LA English
DT Article
DE nafld; mafld; chemerin; insulin resistance; inflammation; obesity;
   physical activity
ID INFLAMMATION
AB Introduction The prevalence of obesity and related disorders is rapidly rising due to altered food habits, sedentary lifestyles and stress. Adipose tissue releases various hormones known as adipokines; one example is chemerin, which is primarily expressed by hepatocytes, adipocytes, and immune cells. Adipokine dysregulation in obesity initiates the cascade of inflammation and insulin resistance that leads to various metabolic disorders such as diabetes mellitus, metabolic syndrome (MS), and metabolic dysfunction- associated fatty liver disease (MAFLD). Aim The aim of our research is to determine serum chemerin levels in obese and non-obese individuals and to estimate the prevalence of MAFLD in obesity. Materials and methods This cross-sectional study was conducted at SRM Medical College Hospital & Research Centre, Tamil Nadu from August 2023 to December 2023. The study group comprised 45 obese and 45 non-obese individuals above 18 years of age. New MAFLD diagnostic criteria and FLI (Fatty Liver Index) formula were used to stratify the cohort. The Godin Leisure-Time Exercise questionnaire was used to assess physical activity levels. Visceral fat was assessed using a body composition analyzer. Student's t-test and ANOVA were used to compare the difference in mean levels across the groups. Pearson's correlation was used to correlate the analyzed parameters. Results Among our obese study participants, nearly 50% reported following a sedentary lifestyle. The prevalence of MAFLD in our obese study group was 44% whereas the prevalence of non-alcoholic fatty disease was found to be only 33%. Fasting plasma glucose (FPG), HbA1c, triglycerides (TG) and chemerin levels were found to vary significantly between the two groups. However, our study did not reveal the association of chemerin with MAFLD, BMI, or visceral fat in obesity. A significant difference in BMI, and visceral fat was observed across groups stratified by their physical activity levels assessed using the Godin leisure questionnaire. Conclusion Our study highlights the effect of physical activity on adipose tissue distribution and metabolic health and does not reveal any significant association of chemerin with MAFLD, BMI, or visceral fat in obesity. Nearly half of the studied obese individuals lead sedentary lifestyles, which highlights the importance of promoting physical activity in the prevention of obesity and related metabolic dysfunction. To validate these findings, future research should involve larger, diverse cohorts and include longitudinal data to track shifts in chemerin levels over time and their impact on metabolic health.
C1 [Aravindraj, R.; Renuka, P.; Vinodhini, V. M.] SRM Med Coll Hosp & Res Ctr, Dept Biochem, Chengalpattu, India.
   [Sundari, S. N. Meenakshi] SRM Med Coll Hosp & Res Ctr, Dept Internal Med, Chengalpattu, India.
C3 SRM Institute of Science & Technology Chennai; SRM Institute of Science
   & Technology Chennai
RP Vinodhini, VM (corresponding author), SRM Med Coll Hosp & Res Ctr, Dept Biochem, Chengalpattu, India.
EM vinodhiv1@srmist.edu.in
RI vinodhini, v.m/ABE-6875-2021
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NR 29
TC 0
Z9 0
U1 0
U2 0
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
EI 2168-8184
J9 CUREUS J MED SCIENCE
JI Cureus J Med Sci
PD AUG 29
PY 2024
VL 16
IS 8
AR e68105
DI 10.7759/cureus.68105
PG 8
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA E7T3D
UT WOS:001304987400009
PM 39347124
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Chan, YM
   Shariff, ZM
   Chin, YS
   Ghazali, SS
   Lee, PY
   Chan, KS
AF Chan, Yoke Mun
   Shariff, Zalilah Mohd
   Chin, Yit Siew
   Ghazali, Sazlina Shariff
   Lee, Ping Yein
   Chan, Kai Sze
TI Associations of alkaline water with metabolic risks, sleep quality,
   muscle strength: A cross-sectional study among postmenopausal women
SO PLOS ONE
LA English
DT Article
ID LIPOPROTEIN CHOLESTEROL RATIO; DRINKING-WATER; REDUCED WATER;
   CARDIOVASCULAR-DISEASE; MENOPAUSAL TRANSITION; OXIDATIVE STRESS;
   MORTALITY; MAGNESIUM; PREVALENCE; CALCIUM
AB Much has been claimed on the health benefits of alkaline water including metabolic syndrome (MetS) and its features with scarcity of scientific evidence. Methods: This cross-sectional comparative study was conducted to determine whether regular consumption of alkaline water confers health advantage on blood metabolites, anthropometric measures, sleep quality and muscle strength among postmenopausal women. A total of 304 community-dwelling postmenopausal women were recruited with comparable proportion of regular drinkers of alkaline water and non-drinkers. Participants were ascertained on dietary intake, lifestyle factors, anthropometric and biochemical measurements. Diagnosis of MetS was made according to Joint Interim Statement definition. A total of 47.7% of the participants met MS criteria, with a significant lower proportion of MetS among the alkaline water drinkers. The observed lower fasting plasma glucose (F(1,294) = 24.20, p = 0.025, partial eta(2) = 0.435), triglyceride/high-density lipoprotein concentration ratio (F(1,294) = 21.06, p = 0.023, partial eta(2) = 0.360), diastolic blood pressure (F(1,294) = 7.85, p = 0.046, partial eta(2) = 0.258) and waist circumference (F(1,294) = 9.261, p = 0.038, partial eta(2) = 0.263) in the alkaline water drinkers could be considered as favourable outcomes of regular consumption of alkaline water. In addition, water alkalization improved duration of sleep (F(1,294) = 32.05, p = 0.007, partial eta(2) = 0.451) and handgrip strength F(1,294) = 27.51, p = 0.011, partial eta(2) = 0.448). Low density lipoprotein cholesterol concentration (F(1,294) = 1.772, p = 0.287, partial eta(2) = 0.014), body weight (F(1,294) = 1.985, p = 0.145, partial eta(2) = 0.013) and systolic blood pressure (F(1,294) = 1.656, p = 0.301, partial eta(2) = 0.010) were comparable between the two different water drinking behaviours. In conclusion, drinking adequate of water is paramount for public health with access to good quality drinking water remains a critical issue. While consumption of alkaline water may be considered as a source of easy-to implement lifestyle to modulate metabolic features, sleep duration and muscle strength, further studies are warranted for unravelling the precise mechanism of alkaline water consumption on the improvement and prevention of MetS and its individual features, muscle strength and sleep duration as well as identification of full spectrum of individuals that could benefit from its consumption.
C1 [Chan, Yoke Mun; Chan, Kai Sze] Univ Putra Malaysia UPM, Dept Dietet, Fac Med & Hlth Sci, Serdang, Malaysia.
   [Chan, Yoke Mun; Chin, Yit Siew] Univ Putra Malaysia UPM, Res Ctr Excellence Nutr & Non Communicable Dis, Fac Med & Hlth Sci, Serdang, Malaysia.
   [Chan, Yoke Mun] Univ Putra Malaysia, Malaysian Res Inst Ageing, Serdang, Malaysia.
   [Shariff, Zalilah Mohd; Chin, Yit Siew] Univ Putra Malaysia UPM, Dept Nutr, Fac Med & Hlth Sci, Serdang, Malaysia.
   [Ghazali, Sazlina Shariff] Univ Putra Malaysia UPM, Dept Family Med, Fac Med & Hlth Sci, Serdang, Malaysia.
   [Lee, Ping Yein] Univ Malaya, UMeHealth Unit, Fac Med, Kuala Lumpur, Malaysia.
C3 Universiti Putra Malaysia; Universiti Putra Malaysia; Universiti Putra
   Malaysia; Universiti Putra Malaysia; Universiti Putra Malaysia;
   Universiti Malaya
RP Chan, YM (corresponding author), Univ Putra Malaysia UPM, Dept Dietet, Fac Med & Hlth Sci, Serdang, Malaysia.; Chan, YM (corresponding author), Univ Putra Malaysia UPM, Res Ctr Excellence Nutr & Non Communicable Dis, Fac Med & Hlth Sci, Serdang, Malaysia.; Chan, YM (corresponding author), Univ Putra Malaysia, Malaysian Res Inst Ageing, Serdang, Malaysia.
EM cym@upm.edu.my
RI Chin, Yit/G-2001-2015; Chan, Kai Sze/IQU-8287-2023; Chan, Yoke
   Mun/L-2965-2015
OI Chan, Yoke Mun/0000-0002-3853-736X
FU Universiti Putra Malaysia
FX The funder (Universiti Putra Malaysia) provided financial research grant
   and support in the form of salaries for authors [YMC, ZMS, YSC, SSG],
   but did not have any additional role in the study design, data
   collection and analysis, decision to publish, or preparation of the
   manuscript. The specific roles of these authors are articulated in the
   'author contributions' section. One of the authors, YMC received
   financial research fund from CUCKOO International (MAL) Pte Ltd. The
   funder had no role in the study design, data collection and analysis,
   decision to publish, or preparation of the manuscript. The fund
   recipient, YMC did not involve in the consultancy, patents, products in
   development or marketed products of the funder. The financial assistant
   does not alter our adherence to PLOS ONE policies on sharing data and
   materials.
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NR 102
TC 4
Z9 4
U1 3
U2 10
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD OCT 31
PY 2022
VL 17
IS 10
AR e0275640
DI 10.1371/journal.pone.0275640
PG 16
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA O6MF8
UT WOS:001044919700011
PM 36315555
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Del Bo, C
   Deon, V
   Campolo, J
   Lanti, C
   Parolini, M
   Porrini, M
   Klimis-Zacas, D
   Riso, P
AF Del Bo, Cristian
   Deon, Valeria
   Campolo, Jonica
   Lanti, Claudia
   Parolini, Marina
   Porrini, Marisa
   Klimis-Zacas, Dorothy
   Riso, Patrizia
TI A serving of blueberry (V. corymbosum) acutely improves
   peripheral arterial dysfunction in young smokers and non-smokers: two
   randomized, controlled, crossover pilot studies
SO FOOD & FUNCTION
LA English
DT Article
ID CONTROLLED CLINICAL-TRIAL; ACUTE CIGARETTE-SMOKING; ENDOTHELIAL
   FUNCTION; BLOOD-PRESSURE; DOUBLE-BLIND; VASCULAR FUNCTION; DARK
   CHOCOLATE; AUGMENTATION INDEX; METABOLIC SYNDROME; OXIDATIVE STRESS
AB cSeveral studies have documented the important role of polyphenol-rich foods in the modulation of vascular remodelling and function. This study aimed to evaluate the capacity of a single portion of blueberry (V. corymbosum) to acutely improve peripheral arterial dysfunction in a group of young volunteers. Twenty-four healthy males (12 non-smokers and 12 smokers) were recruited for two different randomized, controlled, crossover pilot acute studies. In the first study, non-smokers were exposed to a control treatment (C; 300 mL of water with sugar) and a blueberry treatment (BB; 300 g of blueberry). In the second study, smokers underwent 3 different protocols: (1) - smoking treatment (S); (2) - control treatment (CS; 300 mL of water with sugar + smoking); (3) - blueberry treatment (BS; 300 g of blueberry + smoking). Each treatment (1 day long) was separated by a one week washout period. Blood pressure, peripheral arterial function (reactive hyperemia index, RHI, a marker of endothelial function) and arterial stiffness (digital augmentation index, dAix and dAix normalized by considering a heart rate of 75 bpm, dAix@75) were measured before and after each treatment. In the first study, the consumption of blueberry and control treatment acutely increased peripheral arterial function in the group of non-smokers. The improvement in RHI was higher and significantly different after blueberry treatment compared to the control treatment (54.8 +/- 8.4% BB vs. 28.2 +/- 8.3% C; p = 0.01). No effects were observed for markers of arterial stiffness, blood pressure and heart rate. Acute cigarette smoke significantly increased blood pressure and heart rate, while no significant effect was registered in peripheral arterial function and stiffness. The intake of blueberry and control treatment before a cigarette did not counteract the increase in blood pressure and heart rate, while it significantly improved peripheral arterial function. In particular, a significant increase was observed following BS (35.2 +/- 7.5% RHI; p = 0.02) and CS treatments (34.6 +/- 11.9% RHI; p = 0.02) when compared to only smoking treatment. No difference between BS and CS was detected. In conclusion, the intake of blueberry and control treatments acutely improved peripheral arterial dysfunction both in smoker and in non-smoker subjects. Further studies should be performed to confirm the results obtained and reveal the potential mechanisms of blueberry in the improvement of endothelial function.
C1 [Del Bo, Cristian; Deon, Valeria; Lanti, Claudia; Porrini, Marisa; Riso, Patrizia] Univ Milan, Div Human Nutr, Dept Food Environm & Nutr Sci, Milan, Italy.
   [Campolo, Jonica; Parolini, Marina] ASST Great Metropolitan Hosp Niguarda, CNR Inst Clin Physiol CardioThorac & Vasc Dept, Milan, Italy.
   [Klimis-Zacas, Dorothy] Univ Maine, Sch Food & Agr, Orono, ME USA.
C3 University of Milan; Consiglio Nazionale delle Ricerche (CNR); Istituto
   di Fisiologia Clinica (IFC-CNR); University of Maine System; University
   of Maine Orono
RP Del Bo, C (corresponding author), Univ Milan, Div Human Nutr, Dept Food Environm & Nutr Sci, Milan, Italy.
EM cristian.delbo@unimi.it
RI Campolo, Jonica/ABC-5841-2020; Riso, Patrizia/AAC-2072-2019; Del Bò,
   Cristian/AFT-1534-2022; porrini, marisa/AAF-6788-2021
OI DEL BO', CRISTIAN/0000-0001-7562-377X; porrini,
   marisa/0000-0003-2693-3311; Riso, Patrizia/0000-0002-9204-7257; DEON,
   VALERIA/0000-0002-6354-318X
FU Cariplo Foundation [2010.2303]
FX This study was supported by intramural fundings and by a grant (Rif.
   Pratica 2010.2303) from the Cariplo Foundation. We are grateful to all
   our volunteers for their time and commitment.
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NR 52
TC 36
Z9 38
U1 0
U2 14
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PD NOV
PY 2017
VL 8
IS 11
BP 4108
EP 4117
DI 10.1039/c7fo00861a
PG 10
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA FM9HW
UT WOS:000415578600026
PM 29019364
OA Green Submitted
DA 2025-06-11
ER

PT J
AU von Bibra, H
   Siegmund, T
   Kingreen, I
   Riemer, M
   Schuster, T
   Schumm-Draeger, PM
AF von Bibra, Helene
   Siegmund, Thorsten
   Kingreen, Iris
   Riemer, Markus
   Schuster, Tibor
   Schumm-Draeger, Petra-Maria
TI Effects of analogue insulin in multiple daily injection therapy of type
   2 diabetes on postprandial glucose control and cardiac function compared
   to human insulin: a randomized controlled long-term study
SO CARDIOVASCULAR DIABETOLOGY
LA English
DT Article
DE Analogue insulins; Human insulin; Postprandial glucose; Metabolic
   control; Diastolic cardiac function; Insulin resistance; Type 2
   diabetes; Diastolic dysfunction
ID MYOCARDIAL DIASTOLIC FUNCTION; METABOLIC SYNDROME; OXIDATIVE STRESS;
   OBESE-PATIENTS; HEART-FAILURE; ASSOCIATION; DYSFUNCTION; RESISTANCE;
   HYPERGLYCEMIA; VARIABILITY
AB Background: The prevention of cardiovascular disease, including diastolic cardiac dysfunction with its high prevalence and ominous prognosis, is a therapeutic challenge for patients with type 2 diabetes. Both short and long-acting insulin analogues (AI) have been shown to reduce glucose variability and provide potential benefit for cardiovascular disease although the effects on cardiac function have not yet been evaluated. This long-term, prospective, randomized controlled trial in patients with type 2 diabetes (T2D) tested the hypothesis that a multiple daily injection regimen (MDI) with AI improves postmeal glucose excursions in comparison to human insulin (HI) and that the effects of AI improve diastolic cardiac function.
   Methods: For 36 months, MDI treatment in 109 T2D patients was adapted every 3 months (targets: fasting glucose <= 110 mg/dl, postmeal glucose <= 150 mg/dl) in both groups: AI (insulin detemir and insulin aspart, n = 61) and HI (NPH-insulin and regular HI, n = 48). Diastolic cardiac function (myocardial velocity E' using tissue Doppler imaging and the mitral inflow ratio E/A) and vascular function were assessed before and 2 h after a standardized breakfast (48 g carbohydrates). At baseline, both groups were comparable with regards to demographic, cardiac and metabolic data. Analysis of data included traditional statistics as well as the use of a multiple imputation technique shown in brackets [].
   Results: At 36 months, the primary endpoint, postmeal glucose, decreased by 20 +/- 62 mg/dl, p = 0.038 [ p = 0.021] with AI and increased insignificantly with HI (inter-group p = 0.032 [ p = 0.047]) to postmeal glucose levels of 161 +/- 39 with AI vs. 195 +/- 54 mg/dl with HI (inter-group p = 0.002 [ p = 0.010]) whereas the levels of fasting glucose and HbA1c were comparable. With AI, postmeal E' improved by 0.6 +/- 1.4 cm/s, p = 0.009 [ p = 0.002] and fasting E' by 0.4 +/- 1.4 cm/s, p = 0.069 [ p = 0.013], however, E' remained unchanged with HI. These changes were consistent with those of the traditional parameter E/A.
   Conclusions: MDI with AI results in better postmeal glucose control compared to HI. The treatment with AI is associated with improved diastolic cardiac function.
C1 [von Bibra, Helene; Siegmund, Thorsten; Kingreen, Iris; Riemer, Markus; Schumm-Draeger, Petra-Maria] Stadt Klinikum Munchen GmbH, Klinikum Bogenhausen, Clin Endocrinol Diabet & Vasc Med, Munich, Germany.
   [Schuster, Tibor] Tech Univ Munich, Inst Stat & Epidemiol Med, D-80290 Munich, Germany.
C3 Munchen Klinik; Technical University of Munich
RP von Bibra, H (corresponding author), Stadt Klinikum Munchen GmbH, Klinikum Bogenhausen, Clin Endocrinol Diabet & Vasc Med, Munich, Germany.
EM vonbibra@gmx.de
RI Schuster, Tibor/LQJ-4546-2024
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NR 50
TC 4
Z9 4
U1 0
U2 4
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1475-2840
J9 CARDIOVASC DIABETOL
JI Cardiovasc. Diabetol.
PD JAN 16
PY 2016
VL 15
AR 7
DI 10.1186/s12933-015-0320-2
PG 11
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism
GA DA8KK
UT WOS:000368053300001
PM 26772807
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Ghafoorunissa
AF Ghafoorunissa
TI Impact of quality of dietary fat on serum cholesterol and coronary heart
   disease: Focus on plant sterols and other non-glyceride components
SO NATIONAL MEDICAL JOURNAL OF INDIA
LA English
DT Review
ID RICE BRAN OIL; OLIVE OIL; OXIDATIVE STRESS; HDL CHOLESTEROL; LIPID
   PROFILE; PHYTOSTEROLS; ABSORPTION; SAFETY; FOODS; ACIDS
AB Elevated serum low density lipoprotein (LDL) cholesterol is a strong risk factor for coronary heart disease; dietary as well as therapeutic regimens target reduction of serum LDL cholesterol to decrease the morbidity and mortality of coronary heart disease. The fatty acid composition of dietary fat has a marked Impact on serum LDL cholesterol and other risk factors of diet-related chronic diseases (metabolic syndrome, diabetes and coronary heart disease). Besides fatty acids, which constitute >95% of their content, fats in foods contain other fat-soluble chemicals collectively called non-glyceride components. Sterols are a major part of the non-glyceride components of fats in plant foods and get concentrated in vegetable oils. Current evidence suggests that properly solubilized plant sterols or stanols incorporated in ester or free form in various food formulations effectively restrict the absorption of both dietary and biliary cholesterol causing 10%-14% reduction in serum LDL cholesterol in normal, hyperlipidaemic and diabetic subjects. The carotenoid-lowering effect of foods enriched with plant sterols can be corrected by increasing the intake of foods rich in carotenoids. The use of foods enriched with plant sterols as a part of a heart-healthy diet is recommended only after consulting a clinician. Recent studies strongly suggest that even smaller amounts of sterols available from natural plant foods and vegetable oils are important dietary components for lowering serum LDL cholesterol. Furthermore, some of the other non-glyceride components of food fats have one or more of the following functions-vitamin activity, serum LDL cholesterol-lowering and antioxidant activity. Since the hypocholesterolaemic and antioxidant effects of a combination of the non-glyceride components may be more than their individual effects, increasing dietary plant sterols and non-glyceride components from natural plant foods and vegetable oils could provide an additional dietary means for prevention/correction of dyslipidaemia and increasing the antioxidant potential of human diets. The food-based dietary guidelines recommended to ensure an optimal fat quality in the diet of Indians provide high levels of natural plant sterols and other health-promoting non-glyceride components in addition to adequate absolute levels of Individual fatty acids and their optimal balance. National policies to promote these dietary guidelines may contribute to the prevention of coronary heart disease and other diet-related chronic diseases.
C1 [Ghafoorunissa] Natl Inst Nutr, Dept Biochem, Hyderabad 500007, Andhra Pradesh, India.
C3 Indian Council of Medical Research (ICMR); ICMR - National Institute of
   Nutrition (NIN)
RP Ghafoorunissa (corresponding author), Maphar Comfortek, Flat 402, Hyderabad 500028, Andhra Pradesh, India.
EM drghafoor2000@yahoo.com
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NR 69
TC 10
Z9 10
U1 0
U2 3
PU ALL INDIA INST MEDICAL SCIENCES
PI NEW DELHI
PA ANSARI NAGAR, NEW DELHI 110 029, INDIA
SN 0970-258X
J9 NATL MED J INDIA
JI Natl. Med. J. India
PD MAY-JUN
PY 2009
VL 22
IS 3
BP 126
EP 132
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 496JS
UT WOS:000269968000005
PM 19764688
DA 2025-06-11
ER

PT J
AU Lv, CH
   Liu, X
   Chen, SY
   Yi, YH
   Wen, XN
   Li, T
   Qin, S
AF Lv, Chenghao
   Liu, Xin
   Chen, Shiyun
   Yi, Yuhang
   Wen, Xinnian
   Li, Tao
   Qin, Si
TI Extract of Gardenia jasminoides Ellis Attenuates High-Fat
   Diet-Induced Glycolipid Metabolism Disorder in Rats by Targeting Gut
   Microbiota and TLR4/Myd88/NF-κB Pathway
SO ANTIOXIDANTS
LA English
DT Article
DE crocin; Gardenia jasminoides Ellis; glycolipid metabolism disorder; gut
   microbiota; TLR4/Myd88/NF-kappa B pathway
ID ALPHA-AMYLASE; CROCIN; MECHANISMS; TOXICITY; AXIS
AB Gardenia jasminoides Ellis is abundant in crocin and has a longstanding historical usage both as a dietary and natural ethnic medicine. Enhanced studies have increasingly revealed the intricate interplay between glycolipid metabolism and gut microbiota, wherein their imbalance is regarded as a pivotal indicator of metabolic disorders. Currently, the precise molecular mechanism of the crude extract of crocin from Gardenia jasminoides Ellis (GC) targeting gut microbiota to regulate glycolipid metabolism disorder is still unclear. Firstly, we explored the effect of GC on digestive enzymes (alpha-amylase and alpha-glucosidase) in vitro. Secondly, we investigated the effect of GC on the physical and chemical parameters of high-fat diet (HFD) rats, such as body weight change, fasting blood glucose and lipid levels, and liver oxidative stress and injury. Then, 16S rDNA sequencing was used to analyze the effects of GC on the composition and structure of gut microbiota. Finally, the impact of GC on the TLR4/Myd88/NF-kappa B signaling pathway in the intestine was assessed by Western Blotting. In the present study, GC was found to exhibit a hypoglycemic effect in vitro, by inhibition of digestive enzymes. In animal experiments, we observed that GC significantly reduced fasting blood glucose, TC, and TG levels while increasing HDL-C levels. Additionally, GC demonstrated hepatoprotective properties by enhancing liver antioxidative capacity through the upregulation of SOD, CAT, and GSH-Px, while reducing ROS. 16S rDNA sequencing results showed that GC had a significant effect on the gut microbiota of HFD rats, mainly by reducing the ratio of Firmicutes/Bateroidota, and significantly affected the genera related to glycolipid metabolism, such as Akkermansia, Ligilactobacillus, Lactobacillus, Bacteroides, Prevotellaceae, etc. The Western Blotting results demonstrated that GC effectively downregulated the protein expressions of TLR4, Myd88, and NF-kappa B in the intestine of HFD rats, indicating that GC could target the TLR4/Myd88/NF-kappa B pathway to interfere with glycolipid metabolism disorder. Correlation analysis revealed that GC could target the Akkermansia-TLR4/Myd88/NF-kappa B pathway axis which attenuates glycolipid metabolism disorder. Therefore, this study establishes the foundation for GC as a novel therapeutic agent for glycolipid metabolism disorder chemoprevention, and it introduces a novel methodology for harnessing the potential of natural botanical extracts in the prevention and treatment of metabolic syndrome.
C1 [Lv, Chenghao; Liu, Xin; Qin, Si] Hunan Agr Univ, Coll Biosci & Biotechnol, Changsha 410128, Peoples R China.
   [Chen, Shiyun; Yi, Yuhang; Wen, Xinnian; Qin, Si] Hunan Agr Univ, Coll Food Sci & Technol, Changsha 410128, Peoples R China.
   [Li, Tao] Hunan Acad Agr Sci, Hunan Agr Prod Proc Inst, Changsha 410125, Peoples R China.
C3 Hunan Agricultural University; Hunan Agricultural University; Hunan
   Academy of Agricultural Sciences
RP Qin, S (corresponding author), Hunan Agr Univ, Coll Biosci & Biotechnol, Changsha 410128, Peoples R China.; Qin, S (corresponding author), Hunan Agr Univ, Coll Food Sci & Technol, Changsha 410128, Peoples R China.; Li, T (corresponding author), Hunan Acad Agr Sci, Hunan Agr Prod Proc Inst, Changsha 410125, Peoples R China.
EM lvchenghao@stu.hunau.edu.cn; yu_xin@stu.hunau.edu.cn;
   shiyunchen0531@stu.hunau.edu.cn; yiyuhang@stu.hunau.edu.cn;
   wenxinnian@stu.hunau.edu.cn; litao@hunaas.cn; qinsiman@hunau.edu.cn
RI WEN, XIN/KJM-5734-2024; Lv, Chenghao/ABO-9390-2022; Chen,
   Shiyun/GXW-0609-2022
OI Lv, Chenghao/0000-0002-1165-2720
FU Natural Science Foundation of Hunan Province
FX No Statement Available
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NR 44
TC 6
Z9 6
U1 2
U2 15
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD MAR
PY 2024
VL 13
IS 3
AR 293
DI 10.3390/antiox13030293
PG 17
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA ME7L1
UT WOS:001192014300001
PM 38539827
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Petruzzelli, MG
   Margari, M
   Peschechera, A
   de Giambattista, C
   De Giacomo, A
   Matera, E
   Margari, F
AF Petruzzelli, Maria Giuseppina
   Margari, Mariella
   Peschechera, Antonia
   de Giambattista, Concetta
   De Giacomo, Andrea
   Matera, Emilia
   Margari, Francesco
TI Hyperprolactinemia and insulin resistance in drug naive patients with
   early onset first episode psychosis
SO BMC PSYCHIATRY
LA English
DT Article
DE Prolactin regulation; Glucose tolerance; Neuroendocrine dysfunctions;
   Schizophrenia spectrum psychosis; Clinical high risk of psychosis;
   Adolescence; Stress
ID HOMEOSTASIS MODEL ASSESSMENT; METABOLIC SYNDROME; NONAFFECTIVE
   PSYCHOSIS; SCHIZOPHRENIA-PATIENTS; HEALTHY CONTROLS; HOMA-IR;
   1ST-EPISODE PSYCHOSIS; GLUCOSE-TOLERANCE; PITUITARY-GLAND; OBESE
   CHILDREN
AB Background: Hyperprolactinemia and glucose and lipid metabolism abnormalities are often found in patients with schizophrenia and are generally considered secondary to the use of antipsychotic drugs. More recent studies have shown these same neuroendocrine and metabolic abnormalities in antipsychotic naive patients with first episode psychosis (FEP), rising the hypothesis that schizophrenia itself may be related to an abnormal regulation of prolactin secretion and to impaired glucose tolerance. The aim of this study was to compare prolactin levels, glycometabolism parameters and lipid profile between a sample of 31 drug-naive adolescents in the acute phase of FEP and a control group of 23 subjects at clinical high risk (CHR) of developing psychosis.
   Methods: The assessment involved anthropometric data (weight, height, BMI index, pubertal stage) and blood tests (levels of glucose, glycated hemoglobin, serum insulin, triglycerides, total and fractionated cholesterol, prolactin). Insulin resistance (IR) was calculated through the homeostatic model of assessment (HOMA-IR), assuming a cut-off point of 3.16 for adolescent population. FEP patients and CHR controls were compared by using Student's t-distribution (t-test) for parametric data. P < 0.05 was considered significant.
   Results: Significant higher level of prolactin was found in FEP group than in CHR group (mean = 28.93 +/- 27.16 vs 14.29 +/- 7.86, P = 0.009), suggesting a condition of hyperprolactinemia (HPRL). Patients with FEP were more insulin resistant compared to patients at CHR, as assessed by HOMA-IR (mean = 3.07 +/- 1.76 vs 2.11 +/- 1.11, P = 0.043). Differences of fasting glucose (FEP = 4.82 +/- 0.71, CHR = 4.35 +/- 0.62, P = 0.016) and HbA1c (FEP = 25.86 +/- 13.31, CHR = 33.00 +/- 2.95, P = 0.013), were not clinically significant as the mean values were within normal range for both groups. No significant differences were found for lipid profile. A BMI value within the range of normal weight was found for both groups, with no significant differences.
   Conclusion: We suggested that HPRL, increase in HOMA-IR, and psychotic symptoms may be considered different manifestations of the acute onset of schizophrenia spectrum psychosis, with a common neurobiological vulnerability emerging since adolescence. The influence of age and gender on clinical manifestations of psychotic onset should be considered for early prevention and treatment of both schizophrenia spectrum psychosis and neuroendocrine-metabolic dysfunctions.
C1 [Petruzzelli, Maria Giuseppina; Margari, Mariella; Peschechera, Antonia; de Giambattista, Concetta; De Giacomo, Andrea; Matera, Emilia] Univ Bari Aldo Moro, Azienda Osped Univ Policlin Bari, Dept Basic Med Sci Neurosci & Sense Organs, Child Neuropsychiat Unit, Piazza Giulio Cesare 11, I-70124 Bari, Italy.
   [Margari, Francesco] Univ Bari Aldo Moro, Azienda Osped Univ Policlin Bari, Dept Basic Med Sci Neurosci & Sense Organ, Psychiat Unit, Piazza Giulio Cesare 11, I-70124 Bari, Italy.
C3 Universita degli Studi di Bari Aldo Moro; Universita degli Studi di Bari
   Aldo Moro
RP Petruzzelli, MG (corresponding author), Univ Bari Aldo Moro, Azienda Osped Univ Policlin Bari, Dept Basic Med Sci Neurosci & Sense Organs, Child Neuropsychiat Unit, Piazza Giulio Cesare 11, I-70124 Bari, Italy.
EM maria.petruzzelli@uniba.it
RI Peschechera, Antonia/CAG-1792-2022; matera, emilia/GVT-0488-2022;
   Margari, Francesco/K-9457-2016
OI de Giambattista, concetta/0000-0002-7931-5392; De Giacomo,
   Andrea/0000-0002-3454-1679; petruzzelli, maria
   giuseppina/0000-0003-1734-788X
CR [Anonymous], 2014, SCHIZOPHR RES TREATM
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NR 51
TC 22
Z9 22
U1 0
U2 11
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1471-244X
J9 BMC PSYCHIATRY
JI BMC Psychiatry
PD AUG 1
PY 2018
VL 18
AR 246
DI 10.1186/s12888-018-1827-3
PG 7
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA GP0NA
UT WOS:000440505800001
PM 30068291
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Patel, SR
   Bellary, S
   Qin, L
   Balanos, GM
   McIntyre, D
   Gherghel, D
AF Patel, Sunni R.
   Bellary, Srikanth
   Qin, Lu
   Balanos, George M.
   McIntyre, David
   Gherghel, Doina
TI Abnormal Retinal Vascular Reactivity in Individuals with Impaired
   Glucose Tolerance: A Preliminary Study
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Article
ID FLOW-MEDIATED VASODILATION; ENDOTHELIAL DYSFUNCTION; DIABETES-MELLITUS;
   OXIDATIVE STRESS; CARDIOVASCULAR RISK; METABOLIC SYNDROME; VESSEL
   DIAMETERS; FASTING GLUCOSE; BLOOD-FLOW; DISEASE
AB PURPOSE. To investigate the relationship between vascular function parameters measured at the retinal and systemic level and known markers for cardiovascular risk in patients with impaired glucose tolerance (IGT).
   METHODS. Sixty age-and sex-matched white European adults (30 with IGT and 30 with normal glucose tolerance [NGT]) were recruited for the study. Fasting plasma glucose, lipids, and 24-hour blood pressure (BP) were measured in all subjects. Systemic vascular and endothelial function was assessed by using carotid-artery intimal media thickness (cIMT) and flow-mediated dilation (FMD). Retinal vascular reactivity was assessed by the dynamic retinal vessel analyzer. Additionally, blood glutathione (reduced glutathione [GSH], glutathione disulfide [GSSG], and total glutathione [tGSH]) and plasma von Willebrand (vWF) factor levels were also measured.
   RESULTS. Individuals with IGT demonstrated higher BP values (P < 0.001), fasting triglyceride (TG) levels and TG: high-density lipoprotein (HDL) ratios (P < 0.001) than NGT subjects. Furthermore, total: HDL-cholesterol (HDL-C) ratios and Framingham scores were raised (P = 0.010 and P < 0.001, respectively). Blood glutathione levels (GSH, GSSG, and tGSH) were lower (P < 0.001, P = 0.039, and P < 0.001, respectively) while plasma vWF was increased (P = 0.014) in IGT subjects compared to controls. IGT individuals also demonstrated higher IMT in right and left carotid arteries (P = 0.017 and P = 0.005, respectively) alongside larger brachial artery diameter (P = 0.015) and lower FMD percentage (P = 0.026) and glyceryl trinitrate-induced dilation (P = 0.012) than healthy controls. At the retinal arterial level, the IGT subjects showed higher baseline diameter fluctuations (BDFs) (P = 0.026), longer reaction time (RT) (P = 0.032), and reduced baseline-corrected flicker response (bFR) (P = 0.045). In IGT subjects, retinal BDF correlated with total: HDL (P = 0.003) and HDL-C (P = 0.004). Arterial RT also correlated with FMD (P = 0.017) in IGT but not NGT subjects.
   CONCLUSIONS. In IGT individuals there is a relationship between macro-and microvascular function, as well as a direct correlation between the observed retinal microcirculatory changes and established plasma markers for cardiovascular diseases. Multifactorial preventive interventions to decrease vascular risk in these individuals should be considered. (Invest Ophthalmol Vis Sci. 2012; 53: 5102-5108) DOI: 10.1167/iovs.12-9512
C1 [Patel, Sunni R.; Qin, Lu; Gherghel, Doina] Aston Univ, Sch Life & Hlth Sci, Vasc Res Lab, Ophthalm Res Grp, Birmingham B4 7ET, W Midlands, England.
   [Bellary, Srikanth] Aston Univ, Aston Res Ctr Hlth Ageing, Birmingham B4 7ET, W Midlands, England.
   [Balanos, George M.; McIntyre, David] Univ Birmingham, Sch Sport & Exercise Sci, Birmingham B15 2TT, W Midlands, England.
C3 Aston University; Aston University; University of Birmingham
RP Gherghel, D (corresponding author), Aston Univ, Sch Life & Hlth Sci, Vasc Res Lab, Ophthalm Res Grp, Birmingham B4 7ET, W Midlands, England.
EM d.gherghel@aston.ac.uk
RI Bellary, Srikanth/ABA-1977-2020
OI Balanos, George/0000-0002-8971-6691; Gherghel,
   Doina/0000-0001-9439-5573; BELLARY, SRIKANTH/0000-0002-5924-5278
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NR 44
TC 17
Z9 17
U1 0
U2 6
PU ASSOC RESEARCH VISION OPHTHALMOLOGY INC
PI ROCKVILLE
PA 12300 TWINBROOK PARKWAY, ROCKVILLE, MD 20852-1606 USA
SN 0146-0404
EI 1552-5783
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD AUG
PY 2012
VL 53
IS 9
BP 5102
EP 5108
DI 10.1167/iovs.12-9512
PG 7
WC Ophthalmology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Ophthalmology
GA 004QE
UT WOS:000308695400002
PM 22743316
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Hu, Q
   Zhao, LL
   Wang, ZY
   Han, P
   Ding, J
   Wang, T
   Li, J
   Mao, HJ
AF Hu, Qian
   Zhao, Lili
   Wang, Zeyuan
   Han, Ping
   Ding, Jing
   Wang, Ting
   Li, Jia
   Mao, Hongjun
TI Effect of exposure to traffic-related air pollution on liver function
   during the compensation period for cirrhosis: a 4-year follow-up cohort
   study
SO JOURNAL OF ENVIRONMENTAL EXPOSURE ASSESSMENT
LA English
DT Article
DE Traffic-related air pollution; liver function; blood index; compensated
   cirrhosis; distance from roads
ID LONG-TERM EXPOSURE; AIRBORNE PARTICULATE MATTER; METABOLIC SYNDROME;
   OXIDATIVE STRESS; PM2.5; DISEASE; ENZYMES; IMPACT; RISK
AB The increasing number of motor vehicles due to economic and urbanization development has raised concerns about the impact of traffic-related air pollution on human health. Research on the impact of traffic-related pollution on populations, particularly in individuals with liver cirrhosis, is currently lacking. In this study, we utilized data from compensated cirrhosis patients at the Second People's Hospital in Tianjin, China, to investigate the effects of traffic-related air pollution exposure on liver function-related blood indicators. A multiple linear regression model was applied to analyze the exposure to six air pollutants as well as the proximity of patients' residential (or work) addresses to traffic arteries (main roads, secondary roads, highways). The results indicated a significant correlation between traffic-related air pollution and certain levels of liver function. Specifically, PM2.5 exposure was positively correlated with prothrombin time [PT, P < 0.05, 95%CI = (0.119, 0.424)] and international normalized ratio [INR, P < 0.05, 95%CI = (0.003, 0.041)]; SO2 exposure was positively correlated with cholesterol [CHO, P < 0.05, 95%CI = (0.126, 0.947)]; CO exposure was positively correlated with cholinesterase [CHE, P < 0.05, 95%CI = (15,276.644, 55,907.446)], triglyceride [TG, P < 0.05, 95%CI = (0.741, 7.215)], and hemoglobin [Hb, P < 0.05, 95%CI = (26.211, 305.697)]; O-3 exposure was positively correlated with creatine kinase [CK, P < 0.05, 95%CI = (0.012, 0.126)], CHO [P < 0.05, 95%CI = (0.008, 0.248)], and INR [P < 0.05, 95%CI = (0.001, 0.02)]; the distance to main roads was negatively correlated with aspartate aminotransferase [AST, P < 0.05, 95%CI = (-0.041, -0.001)], gamma-glutamyl transferase [GGT, P < 0.05, 95%CI = (-0.041, -0.001)], and serum ferritin [SF, P < 0.05, 95%CI = (-0.348, -0.062)]; and the distance to secondary roads was negatively correlated with PT [P < 0.05, 95%CI = (-0.007, -0.001)]. High-intensity traffic-related air pollution was found to have a negative influence on liver function, potentially causing liver damage. This research provides evidence of the detrimental effects of traffic-related air pollution on the liver.
C1 [Hu, Qian; Wang, Zeyuan; Wang, Ting; Mao, Hongjun] Nankai Univ, Coll Environm Sci & Engn, Tianjin Key Lab Urban Transport Emiss Res, State Environm Protect Key Lab Urban Ambient Air P, Tianjin 300071, Peoples R China.
   [Zhao, Lili; Han, Ping] Tianjin Med Univ, Tianjin Peoples Hosp 2, Dept Hepatol, Peoples Clin Coll 2, Tianjin 300192, Peoples R China.
   [Ding, Jing] Tianjin Environm Meteorol Ctr, CMA NKU Cooperat Lab Atmospher Environm Hlth Res, Tianjin 300074, Peoples R China.
   [Li, Jia] Nankai Univ, Tianjin Peoples Hosp 2, Dept Hepatol, State Key Lab Med Chem Biol, Tianjin 300071, Peoples R China.
C3 Nankai University; Tianjin Medical University; Nankai University
RP Wang, T; Mao, HJ (corresponding author), Nankai Univ, Coll Environm Sci & Engn, Tianjin Key Lab Urban Transport Emiss Res, State Environm Protect Key Lab Urban Ambient Air P, Tianjin 300071, Peoples R China.; Li, J (corresponding author), Nankai Univ, Tianjin Peoples Hosp 2, Dept Hepatol, State Key Lab Med Chem Biol, Tianjin 300071, Peoples R China.
EM wangting@nankai.edu.cn; 18622663700@163.com; hongjun_mao@hotmail.com
RI Wang, zeyuan/LSJ-4913-2024; wang, tingting/IYJ-7765-2023
FU Fundamental Research Funds for the Central Universities of China
   [63241318, 63241322]; Tianjin Key Medical Discipline (Specialty)
   Construction Project [TJYXZDXK-059B]
FX This study is supported by the Fundamental Research Funds for the
   Central Universities of China [63241318, 63241322] and Tianjin Key
   Medical Discipline (Specialty) Construction Project (TJYXZDXK-059B) .
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PU OAE PUBLISHING INC
PI ALHAMBRA
PA 245 E MAIN ST, ST122, ALHAMBRA, CA 91801 USA
EI 2771-5949
J9 J ENVIRON EXPO ASSES
JI J. Environ. Expo. Assess.
PD DEC
PY 2024
VL 3
IS 4
AR 28
DI 10.20517/jeea.2024.19
PG 16
WC Environmental Sciences; Public, Environmental & Occupational Health;
   Toxicology
WE Emerging Sources Citation Index (ESCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health; Toxicology
GA 2KT0H
UT WOS:001484981200001
OA gold
DA 2025-06-11
ER

PT J
AU Kuang, MB
   Yang, RJ
   Huang, X
   Wang, C
   Sheng, GT
   Xie, GB
   Zou, Y
AF Kuang, Maobin
   Yang, Ruijuan
   Huang, Xin
   Wang, Chao
   Sheng, Guotai
   Xie, Guobo
   Zou, Yang
TI Assessing temporal differences in the predictive power of baseline
   TyG-related parameters for future diabetes: an analysis using
   time-dependent receiver operating characteristics
SO JOURNAL OF TRANSLATIONAL MEDICINE
LA English
DT Article
DE TyG index; TyG-related parameters; Diabetes; Time-dependent ROC
   analysis; Prediction
ID TRIGLYCERIDE-GLUCOSE INDEX; FATTY LIVER-DISEASE; INSULIN-RESISTANCE;
   METABOLIC SYNDROME; OXIDATIVE STRESS; SKELETAL-MUSCLE; LIFE-STYLE;
   MELLITUS; OBESITY; CELLS
AB BackgroundIt is known that measuring the triglyceride glucose (TyG) index and TyG-related parameters [triglyceride glucose-body mass index (TyG-BMI), triglyceride glucose-waist circumference (TyG-WC), and triglyceride glucose-waist to height ratio (TyG-WHtR)] can predict diabetes; this study aimed to compare the predictive value of the baseline TyG index and TyG-related parameters for the onset of diabetes at different future periods.MethodsWe conducted a longitudinal cohort study involving 15,464 Japanese people who had undergone health physical examinations. The subject's TyG index and TyG-related parameters were measured at the first physical examination, and diabetes was defined according to the American Diabetes Association criteria. Multivariate Cox regression models and time-dependent receiver operating characteristic (ROC) curves were constructed to examine and compare the risk assessment/predictive value of the TyG index and TyG-related parameters for the onset of diabetes in different future periods.ResultsThe mean follow-up period of the current study cohort was 6.13 years, with a maximum of 13 years, and the incidence density of diabetes was 39.88/10,000 person-years. In multivariate Cox regression models with standardized hazard ratios (HRs), we found that both the TyG index and TyG-related parameters were significantly and positively associated with diabetes risk and that the TyG-related parameters were stronger in assessing diabetes risk than the TyG index, with TyG-WC being the best parameter (HR per SD increase: 1.70, 95% CI 1.46, 1.97). In addition, TyG-WC also showed the highest predictive accuracy in time-dependent ROC analysis for diabetes occurring in the short-term (2-6 years), while TyG-WHtR had the highest predictive accuracy and the most stable predictive threshold for predicting the onset of diabetes in the medium- to long-term (6-12 years).ConclusionsThese results suggest that the TyG index combined with BMI, WC, and WHtR can further improve its ability to assess/predict the risk of diabetes in different future periods, where TyG-WC was not only the best parameter for assessing diabetes risk but also the best risk marker for predicting future diabetes in the short-term, while TyG-WHtR may be more suitable for predicting future diabetes in the medium- to long-term.
C1 [Kuang, Maobin; Yang, Ruijuan; Huang, Xin; Wang, Chao] Nanchang Univ, Med Coll, Nanchang 330006, Jiangxi, Peoples R China.
   [Kuang, Maobin; Huang, Xin; Wang, Chao; Sheng, Guotai; Xie, Guobo] Nanchang Med Coll, Jiangxi Prov Peoples Hosp, Affiliated Hosp 1, Dept Cardiol, Nanchang 330006, Jiangxi, Peoples R China.
   [Kuang, Maobin; Huang, Xin; Wang, Chao; Zou, Yang] Nanchang Med Coll, Jiangxi Prov Peoples Hosp, Affiliated Hosp 1, Jiangxi Cardiovasc Res Inst, Nanchang 330006, Jiangxi, Peoples R China.
   [Yang, Ruijuan] Nanchang Med Coll, Jiangxi Prov Peoples Hosp, Affiliated Hosp 1, Dept Endocrinol, Nanchang 330006, Jiangxi, Peoples R China.
C3 Nanchang University; Nanchang Medical College; Nanchang Medical College;
   Nanchang Medical College
RP Xie, GB (corresponding author), Nanchang Med Coll, Jiangxi Prov Peoples Hosp, Affiliated Hosp 1, Dept Cardiol, Nanchang 330006, Jiangxi, Peoples R China.; Zou, Y (corresponding author), Nanchang Med Coll, Jiangxi Prov Peoples Hosp, Affiliated Hosp 1, Jiangxi Cardiovasc Res Inst, Nanchang 330006, Jiangxi, Peoples R China.
EM xgb19810830@163.com; jxyxyzy@163.com
OI Kuang, maobin/0009-0000-0136-7566; Zou, Yang/0000-0002-9373-928X
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NR 65
TC 24
Z9 26
U1 5
U2 19
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1479-5876
J9 J TRANSL MED
JI J. Transl. Med.
PD MAY 4
PY 2023
VL 21
IS 1
AR 299
DI 10.1186/s12967-023-04159-7
PG 13
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA F1HT7
UT WOS:000979933900001
PM 37138277
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Teich, T
   Pivovarov, JA
   Porras, DP
   Dunford, EC
   Riddell, MC
AF Teich, Trevor
   Pivovarov, Jacklyn A.
   Porras, Deanna P.
   Dunford, Emily C.
   Riddell, Michael C.
TI Curcumin limits weight gain, adipose tissue growth, and glucose
   intolerance following the cessation of exercise and caloric restriction
   in rats
SO JOURNAL OF APPLIED PHYSIOLOGY
LA English
DT Article
DE weight regain; detraining; curcumin; inflammation; adipose tissue
ID INDUCED INSULIN-RESISTANCE; DIET-INDUCED OBESITY; VOLUNTARY EXERCISE;
   METABOLIC SYNDROME; VISCERAL OBESITY; EPIDIDYMAL FAT; INFLAMMATION;
   MUSCLE; MEN; MECHANISMS
AB Weight regain, adipose tissue growth, and insulin resistance can occur within days after the cessation of regular dieting and exercise. This phenomenon has been attributed, in part, to the actions of stress hormones as well as local and systemic inflammation. We investigated the effect of curcumin, a naturally occurring polyphenol known for its anti-inflammatory properties and inhibitory action on 11 beta-HSD1 activity, on preserving metabolic health and limiting adipose tissue growth following the cessation of daily exercise and caloric restriction (CR). SpragueDawley rats (6-7 wk old) underwent a "training" protocol of 24-h voluntary running wheel access and CR (15-20 g/day; similar to 50-65% of ad libitum intake) for 3 wk ("All Trained") or were sedentary and fed ad libitum ("Sed"). After 3 wk, All Trained were randomly divided into one group which was terminated immediately ("Trained"), and two detrained groups which had their wheels locked and were reintroduced to ad libitum feeding for 1 wk. The wheel locked groups received either a daily gavage of a placebo ("Detrained + Placebo") or curcumin (200 mg/kg) ("Detrained + Curcumin"). Cessation of daily CR and exercise caused an increase in body mass, as well as a 9- to 14-fold increase in epididymal, perirenal, and inguinal adipose tissue mass, all of which were attenuated by curcumin (P < 0.05). Insulin area under the curve (AUC) during an oral glucose tolerance test, HOMA-IR, and C-reactive protein (CRP) were elevated 6-, 9-, and 2-fold, respectively, in the Detrained + Placebo group vs. the Trained group (all P < 0.05). Curcumin reduced insulin AUC, HOMA-IR, and CRP vs. the placebo group (all P < 0.05). Our results indicate that curcumin has a protective effect against weight regain and impaired metabolic control following a successful period of weight loss through diet and exercise, perhaps via inhibition of glucocorticoid action and inflammation.
   NEW & NOTEWORTHY Weight regain after dieting and exercise is a common phenomenon plaguing many individuals. The biological mechanisms underlying weight regain are incompletely understood and are likely multifactorial. In this paper, we examined the metabolic implications of curcumin, a compound known for its anti-inflammatory properties and inhibitory action on the enzyme 11 beta-HSD1, in a rodent model of adiposity rebound after the cessation of diet and exercise.
C1 [Teich, Trevor; Pivovarov, Jacklyn A.; Porras, Deanna P.; Dunford, Emily C.; Riddell, Michael C.] York Univ, Muscle Hlth Res Ctr, Sch Kinesiol & Hlth Sci, Toronto, ON M3J 1P3, Canada.
C3 York University - Canada
RP Riddell, MC (corresponding author), York Univ, Muscle Hlth Res Ctr, Sch Kinesiol & Hlth Sci, Toronto, ON M3J 1P3, Canada.
EM mriddell@yorku.ca
FU Natural Science and Engineering Research Council of Canada Discovery
   Grant [261306]; York University Muscle Health Research Centre Graduate
   Student Fellowship; Ontario Graduate Scholarship; Natural Science and
   Engineering Research Council of Canada Doctoral Scholarship
FX This work was funded by the Natural Science and Engineering Research
   Council of Canada Discovery Grant (Grant No. 261306) to M. C. Riddell.
   T. Teich is the recipient of the York University Muscle Health Research
   Centre Graduate Student Fellowship. D. P. Porras is a recipient of the
   Ontario Graduate Scholarship. E. C. Dunford is a recipient of the
   Natural Science and Engineering Research Council of Canada Doctoral
   Scholarship.
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NR 56
TC 11
Z9 11
U1 1
U2 18
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 8750-7587
EI 1522-1601
J9 J APPL PHYSIOL
JI J. Appl. Physiol.
PD DEC
PY 2017
VL 123
IS 6
BP 1625
EP 1634
DI 10.1152/japplphysiol.01115.2016
PG 10
WC Physiology; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology; Sport Sciences
GA FU0RB
UT WOS:000423556900018
PM 28839007
OA Green Published
DA 2025-06-11
ER

PT J
AU Giles, ED
   Hagman, J
   Pan, ZX
   MacLean, PS
   Higgins, JA
AF Giles, Erin D.
   Hagman, Jennifer
   Pan, Zhaoxing
   MacLean, Paul S.
   Higgins, Janine A.
TI Weight restoration on a high carbohydrate refeeding diet promotes rapid
   weight regain and hepatic lipid accumulation in female anorexic rats
SO NUTRITION & METABOLISM
LA English
DT Article
DE Anorexia nervosa; Refeeding; Indirect calorimetry; Energy expenditure;
   Activity-based anorexia; Carbohydrate; Diet; Rat; Clinical
ID OBESITY-PRONE RATS; METABOLIC SYNDROME; EATING-DISORDERS; HEALTHY-MEN;
   HIGH-FAT; EXERCISE; NERVOSA; PATHOGENESIS; DEPOSITION; REDUCTION
AB Background: There is currently no standard clinical refeeding diet for the treatment of anorexia nervosa (AN). To provide the most efficacious AN clinical care, it is necessary to define the metabolic effects of current refeeding diets.
   Methods: An activity-based model of anorexia nervosa (AN) was used in female rats. AN was induced over 7d by timed access to low fat (LF) diet with free access to a running wheel. Plasma hormones/metabolites and body composition were assessed at baseline, AN diagnosis (day 0), and following 28d of refeeding on LF diet. Energy balance and expenditure were measured via continuous indirect calorimetry on days -3 to +3.
   Results: AN induction caused stress as indicated by higher levels of corticosterone versus controls (p < 0.0001). The rate of weight gain during refeeding was higher in AN rats than controls (p = 0.0188), despite lower overall energy intake (p < 0.0001). This was possible due to lower total energy expenditure (TEE) at the time of AN diagnosis which remained significantly lower during the entire refeeding period, driven by markedly lower resting energy expenditure (REE). AN rats exhibited lower lipid accumulation in visceral adipose tissues (VAT) but much higher liver accumulation (62 % higher in AN than control; p < 0.05) while maintaining the same total body weight as controls. It is possible that liver lipid accumulation was caused by overfeeding of carbohydrate suggesting that a lower carbohydrate, higher fat diet may be beneficial during AN treatment. To test whether such a diet would be accepted clinically, we conducted a study in adolescent female AN patients which showed equivalent palatability and acceptability for LF and moderate fat diets. In addition, this diet was feasible to provide clinically during inpatient treatment in this population.
   Conclusion: Refeeding a LF diet to restore body weight in female AN rats caused depressed TEE and REE which facilitated rapid regain. However, this weight gain was metabolically unhealthy as it resulted in elevated lipid accumulation in the liver. It is necessary to investigate the use of other diets, such as lower carbohydrate, moderate fat diets, in pre-clinical models to develop the optimal clinical refeeding diets for AN.
C1 [Giles, Erin D.; MacLean, Paul S.; Higgins, Janine A.] Univ Colorado Anschutz Med Campus, Ctr Human Nutr, Aurora, CO USA.
   [Giles, Erin D.; MacLean, Paul S.] Univ Colorado Anschutz Med Campus, Sch Med, Div Endocrinol Diabet & Metab, Aurora, CO USA.
   [Hagman, Jennifer] Univ Colorado Anschutz Med Campus, Sch Med, Dept Psychiat, Aurora, CO USA.
   [Pan, Zhaoxing] Childrens Hosp Colorado, Biostat Core, Res Inst, Aurora, CO USA.
   [Higgins, Janine A.] Univ Colorado Anschutz Med Campus, Sch Med, Dept Pediat, Aurora, CO USA.
C3 University of Colorado System; University of Colorado Anschutz Medical
   Campus; University of Colorado System; University of Colorado Anschutz
   Medical Campus; University of Colorado System; University of Colorado
   Anschutz Medical Campus; Children's Hospital Colorado; University of
   Colorado System; University of Colorado Anschutz Medical Campus
RP Higgins, JA (corresponding author), Univ Colorado Anschutz Med Campus, Ctr Human Nutr, Aurora, CO USA.; Higgins, JA (corresponding author), Univ Colorado Anschutz Med Campus, Sch Med, Dept Pediat, Aurora, CO USA.
EM Janine.Higgins@childrenscolorado.org
RI MacLean, Paul/A-7887-2008; Giles, Erin/AAD-9753-2020; Hagman,
   Jennifer/R-8240-2017
OI Giles, Erin/0000-0002-8677-2831; Hagman, Jennifer/0000-0002-7770-3092;
   Higgins, Janine/0000-0002-4273-194X
FU National Institutes of Health [R01 DK038088]; Pilot Award from the
   Colorado Clinical Translational Research Institute [UL1 TR001082];
   Colorado Nutrition Obesity Research Center (NORC) [P30 DK48520]
FX This work was supported by the National Institutes of Health to PSM (R01
   DK038088) and a Pilot Award from the Colorado Clinical Translational
   Research Institute to JAH (UL1 TR001082). We appreciate the support from
   the core facilities of the Colorado Nutrition Obesity Research Center
   (NORC, P30 DK48520).
CR American Psychiatric Association American Psychiatric Association, 2013, Diagnostic and statistical manual of mental disorders: DSM-5TM, DOI DOI 10.1176/APPI.BOOKS.9780890425596
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NR 38
TC 6
Z9 8
U1 0
U2 11
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1743-7075
J9 NUTR METAB
JI Nutr. Metab.
PD MAR 1
PY 2016
VL 13
AR 18
DI 10.1186/s12986-016-0077-y
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA DF4EU
UT WOS:000371301400002
PM 26937246
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Di Minno, MND
   Russolillo, A
   Lupoli, R
   Ambrosino, P
   Di Minno, A
   Tarantino, G
AF Di Minno, Matteo Nicola Dario
   Russolillo, Anna
   Lupoli, Roberta
   Ambrosino, Pasquale
   Di Minno, Alessandro
   Tarantino, Giovanni
TI Omega-3 fatty acids for the treatment of non-alcoholic fatty liver
   disease
SO WORLD JOURNAL OF GASTROENTEROLOGY
LA English
DT Article
DE Hepatic steatosis; Non-alcoholic fatty liver disease; Omega-3
   polyunsaturated fatty acids; Animal models
ID ACTIVATED-RECEPTOR-ALPHA; ELEMENT-BINDING PROTEIN-1; AMELIORATE HEPATIC
   STEATOSIS; OXIDATIVE STRESS; INSULIN-RESISTANCE; GENE-EXPRESSION; ACID
   REGULATION; MURINE MODEL; MOLECULAR-MECHANISMS; METABOLIC SYNDROME
AB Non-alcoholic fatty liver disease (NAFLD) has been recognized as a major health burden. It is the most important cause of chronic liver disease and a major independent cardiovascular risk factor. Lacking a definite treatment for NAFLD, a specific diet and an increase in physical activity represent the most commonly used therapeutic approaches. In this review, major literature data about the use of omega-3 polyunsaturated fatty acids (n-3 PUFAs) as a potential treatment of NAFLD have been described. n-3 PUFAs, besides having a beneficial impact on most of the cardio-metabolic risk factors (hypertension, hyperlipidemia, endothelial dysfunction and atherosclerosis) by regulating gene transcription factors [i.e., peroxisome proliferator-activated receptor (PPAR) alpha, PPAR gamma, sterol regulatory element-binding protein-1, carbohydrate responsive element-binding protein], impacts both lipid metabolism and on insulin sensitivity. In addition to an enhancement of hepatic beta oxidation and a decrease of the endogenous lipid production, n-3 PUFAs are able to determine a significant reduction of the expression of pro-inflammatory molecules (tumor necrosis factor-alpha and interleukin-6) and of oxygen reactive species. Further strengthening the results of the in vitro studies, both animal models and human intervention trials, showed a beneficial effect of n-3 PUFAs on the severity of NAFLD as expressed by laboratory parameters and imaging measurements. Despite available results provided encouraging data about the efficacy of n-3 PUFAs as a treatment of NAFLD in humans, well-designed randomized controlled trials of adequate size and duration, with histological endpoints, are needed to assess the long-term safety and efficacy of PUFA, as well as other therapies, for the treatment of NAFLD and non-alcoholic steatohepatitis patients. It is worthwhile to consider that n-3 PUFAs cannot be synthesized by the human body and must be derived from exogenous sources (fish oil, flaxseeds, olive oil) which are typical foods of the Mediterranean diet, known for its beneficial effects in preventing obesity, diabetes and, in turn, cardiovascular events. According to these data, it is important to consider that most of the beneficial effects of n-3 PUFAs can also be obtained by an equilibrate nutrition program. (C) 2012 Baishideng. All rights reserved.
C1 [Di Minno, Matteo Nicola Dario; Russolillo, Anna; Lupoli, Roberta; Ambrosino, Pasquale; Di Minno, Alessandro; Tarantino, Giovanni] Univ Naples Federico II, Dept Clin & Expt Med, Reg Reference Ctr Coagulat Disorders, I-80131 Naples, Italy.
C3 University of Naples Federico II
RP Di Minno, MND (corresponding author), Univ Naples Federico II, Dept Clin & Expt Med, Reg Reference Ctr Coagulat Disorders, Via S Pansini 5, I-80131 Naples, Italy.
EM dario.diminno@hotmail.it
RI Tarantino, Giovanni/AAW-2007-2021; Ambrosino, Pasquale/AAD-1934-2020; Di
   Minno, Matteo/D-5141-2012; Di Minno, Alessandro/K-1948-2016; Lupoli,
   Roberta/K-9880-2016
OI Ambrosino, Pasquale/0000-0002-9398-0428; Di Minno,
   Matteo/0000-0001-8059-3819; Di Minno, Alessandro/0000-0001-8084-9976;
   Lupoli, Roberta/0000-0002-1701-7197
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NR 82
TC 129
Z9 137
U1 0
U2 52
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 8226 REGENCY DR, PLEASANTON, CA 94588 USA
SN 1007-9327
EI 2219-2840
J9 WORLD J GASTROENTERO
JI World J. Gastroenterol.
PD NOV 7
PY 2012
VL 18
IS 41
BP 5839
EP 5847
DI 10.3748/wjg.v18.i41.5839
PG 9
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 038SU
UT WOS:000311195200002
PM 23139599
OA Green Accepted, Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Huang, SQ
   He, Q
   Zhao, JM
   Choi, S
   Gong, H
AF Huang, Shaoqun
   He, Qiao
   Zhao, Jingmin
   Choi, Seok
   Gong, Hongyang
TI Association of weight-adjusted waist index (WWI) with overactive bladder
   (OAB): a cross-sectional study from NHANES 2005-2018
SO SCIENTIFIC REPORTS
LA English
DT Article
DE Weight-adjusted waist index; Overactive bladder; NHANES; Cross-sectional
   study; Dietary inflammatory index
ID DIETARY INFLAMMATORY INDEX; PELVIC FLOOR DISORDERS; BODY-MASS INDEX;
   URINARY-INCONTINENCE; METABOLIC SYNDROME; OBESE WOMEN; OVERWEIGHT;
   PREVALENCE; SYMPTOMS; STRESS
AB The overactive bladder (OAB) is associated with obesity and inflammation. The weight-adjusted waist index (WWI) has emerged as a novel and more accurate measure of obesity compared to traditional indices, while the Dietary Inflammatory Index (DII) quantifies the inflammatory potential of one's diet. However, the relationship between WWI, DII, and OAB remains unclear. This study aims to elucidate the association between WWI and OAB and to determine whether this relationship is mediated by dietary inflammation. Data from the National Health and Nutrition Examination Survey (NHANES) between 2005 and 2018, comprising 10,176 participants, were analyzed in this study. The association between WWI and OAB was examined using multivariate logistic regression models, smooth curve fitting, and subgroup analysis. Furthermore, the predictive capabilities of various anthropometric indices-including WWI, body roundness index (BRI), body mass index (BMI), waist circumference, body fat percentage (BF%), and weight-on OAB incidence were assessed using Receiver Operating Characteristic (ROC) curve analysis. Finally, a mediation analysis was conducted to explore whether the DII mediates the relationship between WWI and OAB. There was a significant positive association between WWI and OAB. After adjusting for covariates, for each unit increase in WWI, there was a 40% increase in the prevalence of OAB (OR 1.40, 95% CI 1.25-1.58, P < 0.001). This positive correlation persisted when WWI was categorized into quartiles. The dose-response curve showed a significant linear positive correlation between WWI and OAB. The correlation between WWI and OAB persisted in subgroup analysis. The ROC curve analysis revealed that WWI had a superior predictive capability compared to traditional obesity indices, with an area under the curve (AUC) of 0.661 (95% CI 0.648-0.674, all P < 0.001). The results of the mediation analysis showed that 5.02% of the association between WWI and OAB was mediated by DII (P = 0.016). Our findings suggest that individuals with higher WWI may have an increased risk of OAB. Additionally, an anti-inflammatory diet may be beneficial in preventing OAB. Given the cross-sectional nature of this study, we cannot establish a causal relationship. Future longitudinal studies are needed to validate this association and investigate the potential biological mechanisms underlying this relationship.
C1 [Huang, Shaoqun] Fujian Univ Tradit Chinese Med, Dept Oncol Surg, Fuzhou Hosp Tradit Chinese Med, Fuzhou, Fujian, Peoples R China.
   [He, Qiao; Zhao, Jingmin] Tianjin Univ Tradit Chinese Med, Grad Sch, Tianjin, Peoples R China.
   [Choi, Seok; Gong, Hongyang] Chosun Univ, Coll Med, Dept Physiol, 309 Pilmun Daero, Gwangju 61452, South Korea.
C3 Fujian University of Traditional Chinese Medicine; Tianjin University of
   Traditional Chinese Medicine; Chosun University
RP Gong, H (corresponding author), Chosun Univ, Coll Med, Dept Physiol, 309 Pilmun Daero, Gwangju 61452, South Korea.
EM hygong@chosun.ac.kr
RI huang, shaoqun/LIG-2455-2024
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NR 47
TC 1
Z9 1
U1 1
U2 1
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD APR 16
PY 2025
VL 15
IS 1
AR 13207
DI 10.1038/s41598-025-98050-8
PG 11
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 1PA7Y
UT WOS:001470261000007
PM 40240487
DA 2025-06-11
ER

PT J
AU Beejmohun, V
   Peytavy-Izard, M
   Mignon, C
   Muscente-Paque, D
   Deplanque, X
   Ripoll, C
   Chapal, N
AF Beejmohun, Vickram
   Peytavy-Izard, Marie
   Mignon, Cyril
   Muscente-Paque, Delphine
   Deplanque, Xavier
   Ripoll, Christophe
   Chapal, Nicolas
TI Acute effect of Ceylon cinnamon extract on postprandial glycemia:
   alpha-amylase inhibition, starch tolerance test in rats, and randomized
   crossover clinical trial in healthy volunteers
SO BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Article
DE Cinnamon extract; Postprandial glycemia; Glycemic index; Alpha-amylase
   inhibitor; Starch digestion; Pre-diabetes; Metabolic syndrome
ID TYPE-2 DIABETIC-PATIENTS; DISEASE RISK-FACTORS; PLASMA-GLUCOSE;
   BLOOD-GLUCOSE; HEART-DISEASE; INDEX DIET; OVERWEIGHT; WEIGHT; LIPIDS;
   HYPERGLYCEMIA
AB Background: Postprandial hyperglycemia is a known risk factor for the development of several health disorders including type 2 diabetes, obesity, oxidative stress, and cardiovascular diseases. One encouraging approach for a better control of postprandial glycemia is to reduce carbohydrate digestion. Cinnamon extracts have been known for managing blood glucose. However, their effects on inhibiting digestion of carbohydrate have been poorly analyzed to date. The aim of this study was to investigate the acute effect of a specific Ceylon cinnamon hydro-alcoholic extract (CCE) on carbohydrate digestion and post-meal blood glucose reduction.
   Methods: In vitro enzymatic assays and in vivo starch tolerance tests in rats were designed as preclinical assays. Then, a randomized, double-blind, placebo-controlled, cross-over clinical trial was conducted in 18 healthy female and male volunteers. Following the intake of 1 g of CCE, the subjects ate a standardized meal. Blood samples were collected during the 2 hours following the meal to measure glucose and insulin concentrations. Areas under the curves were calculated and statistical differences between the CCE and placebo groups were analyzed using the Mann Whitney-Wilcoxon test.
   Results: CCE has demonstrated in the in vitro study that it inhibited pancreatic alpha-amylase activity with an IC50 of 25 mu g/mL. In the in vivo study, CCE was shown to acutely reduce the glycemic response to starch in a dose-dependent manner in rats. This effect was significant from the dose of 12.5 mg/kg of body weight. In both, the in vitro and in vivo studies, the hydro-alcoholic extract has shown to be more efficacious than the aqueous extract. In the human clinical trial, 1 g of CCE lowered the area under the curve of glycemia between 0 and 120 min by 14.8% (P = 0.15) and between 0 and 60 min by 21.2% (P < 0.05) compared to the placebo. This effect occurred without stimulating insulin secretion. No adverse effects were reported.
   Conclusion: These results suggest that Ceylon cinnamon hydro-alcoholic extract (CCE) may provide a natural and safe solution for the reduction of postprandial hyperglycemia and therefore help to reduce the risks of developing metabolic disorders.
C1 [Beejmohun, Vickram; Peytavy-Izard, Marie; Mignon, Cyril; Chapal, Nicolas] Dialpha SAS, F-34980 Montferrier Sur Lez, France.
   [Muscente-Paque, Delphine; Deplanque, Xavier; Ripoll, Christophe] Naturalpha SAS, F-59120 Loos, France.
RP Chapal, N (corresponding author), Dialpha SAS, Parc Agropolis 2,2196 Blvd Lironde, F-34980 Montferrier Sur Lez, France.
EM n.chapal@dialpha.com
OI Ripoll, Christophe/0009-0004-1264-7001
FU French Ministry of Education and Research; BpiFrance; Region
   Languedoc-Roussillon; Business & Innovation Center of Montpellier
   Agglomeration
FX This research was supported by the French Ministry of Education and
   Research, the BpiFrance, the Region Languedoc-Roussillon, and the
   Business & Innovation Center of Montpellier Agglomeration.
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NR 32
TC 54
Z9 56
U1 0
U2 38
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1472-6882
J9 BMC COMPLEM ALTERN M
JI BMC Complement. Altern. Med.
PD SEP 23
PY 2014
VL 14
AR 351
DI 10.1186/1472-6882-14-351
PG 11
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA AQ2VJ
UT WOS:000342647500005
PM 25249234
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Ungvari, Z
   Fekete, M
   Varga, P
   Lehoczki, A
   Fekete, JT
   Ungvari, A
   Gyorffy, B
AF Ungvari, Zoltan
   Fekete, Monika
   Varga, Peter
   Lehoczki, Andrea
   Fekete, Janos Tibor
   Ungvari, Anna
   Gyorffy, Balazs
TI Overweight and obesity significantly increase colorectal cancer risk: a
   meta-analysis of 66 studies revealing a 25-57% elevation in risk
SO GEROSCIENCE
LA English
DT Article; Early Access
DE Epidemiology; Aging; Age-related disease; Malignancy; Neoplasm;
   Adiposity; Adipose; Colon carcinoma
ID BODY-MASS-INDEX; PERIVASCULAR ADIPOSE-TISSUE; POPULATION-BASED COHORT;
   LOW-GRADE INFLAMMATION; WEIGHT CHANGE; COLON-CANCER; OXIDATIVE STRESS;
   COGNITIVE IMPAIRMENT; METABOLIC SYNDROME; RECTAL-CANCER
AB The incidence of colorectal cancer (CRC) has been steadily rising, and obesity has been identified as a significant risk factor. Numerous studies suggest a strong correlation between excess body weight and increased risk of CRC, but comprehensive quantification through pooled analysis remains limited. This study aims to systematically review and meta-analyze the existing literature to evaluate the association between obesity and CRC risk, considering variations across sex and study designs. A systematic literature search was conducted in PubMed, Cochrane Central Register of Controlled Trials (CENTRAL), and Web of Science to identify randomized controlled trials and human clinical trials from 1992 to 2024. Statistical analysis was performed using the https://metaanalysisonline.com web application using a random effects model to estimate the pooled hazard rates (HR). Forest plots, funnel plots, and Z-score plots were utilized to visualize results. We identified 52 clinical trials and 14 case-control studies, encompassing a total of 83,251,050 and 236,877 subjects, respectively. The pooled analysis indicated that obesity significantly increased the prevalence of CRC (HR = 1.36, 95% CI = 1.24-1.48, p < 0.01). This effect was consistent across sexes, with HRs of 1.57 (95% CI = 1.38-1.78, p = 0.01) for males and 1.25 (95% CI = 1.14-1.38, p < 0.01) for females. Case-control studies specifically showed an effect, but with marginal significance only (HR = 1.27, 95% CI = 0.98-1.65, p = 0.07). The Z-score plot indicated the need for additional analysis in the case-control group. A significant heterogeneity was observed across studies in all four settings. This meta-analysis provides robust evidence that obesity is a significant risk factor for colorectal cancer, with an overall hazard rate indicating a 36% increased risk. The effect is pronounced across both sexes, with males showing a slightly higher risk compared to females. Although case-control studies showed a weaker association, the overall trend supports the link between obesity and CRC. These results underscore the importance of public health interventions aimed at reducing obesity to potentially lower the risk of colorectal cancer.
C1 [Ungvari, Zoltan] Univ Oklahoma, Hlth Sci Ctr, Dept Neurosurg, Vasc Cognit Impairment Neurodegenerat & Hlth Brain, Oklahoma City, OK USA.
   [Ungvari, Zoltan] Univ Oklahoma, Stephenson Canc Ctr, Oklahoma City, OK USA.
   [Ungvari, Zoltan] Univ Oklahoma, Hlth Sci Ctr, Oklahoma Ctr Geroscience & Hlth Brain Aging, Oklahoma City, OK USA.
   [Ungvari, Zoltan] Univ Oklahoma, Hlth Sci Ctr, Coll Publ Hlth, Dept Hlth Promot Sci, Oklahoma City, OK USA.
   [Ungvari, Zoltan] Semmelweis Univ, Inst Prevent Med & Publ Hlth, Doctoral Coll, Int Training Program Geroscience, Budapest, Hungary.
   [Fekete, Monika; Varga, Peter; Lehoczki, Andrea; Ungvari, Anna] Semmelweis Univ, Inst Prevent Med & Publ Hlth, Budapest, Hungary.
   [Fekete, Janos Tibor; Gyorffy, Balazs] Semmelweis Univ, Dept Bioinformat, H-1094 Budapest, Hungary.
   [Fekete, Janos Tibor; Gyorffy, Balazs] HUN REN Res Ctr Nat Sci, Inst Mol Life Sci, Canc Biomarker Res Grp, H-1117 Budapest, Hungary.
   [Gyorffy, Balazs] Univ Pecs, Med Sch, Dept Biophys, H-7624 Pecs, Hungary.
C3 University of Oklahoma System; University of Oklahoma Health Sciences
   Center; University of Oklahoma System; University of Oklahoma Health
   Sciences Center; University of Oklahoma System; University of Oklahoma
   Health Sciences Center; University of Oklahoma System; University of
   Oklahoma Health Sciences Center; Semmelweis University; Semmelweis
   University; Semmelweis University; HUN-REN; HUN-REN Research Centre for
   Natural Sciences; University of Pecs
RP Ungvari, A (corresponding author), Semmelweis Univ, Inst Prevent Med & Publ Hlth, Budapest, Hungary.
EM Ungann2004@gmail.com
RI Gyorffy, Balazs/AAA-9135-2021; Ungvari, Zoltan/GZK-8127-2022; Fekete,
   János Tibor/J-4505-2018; monika, fekete/AAE-4135-2020; Lehoczki,
   Andrea/LQK-7571-2024
FU Semmelweis University; National Institute on Aging [RF1AG072295,
   R01AG055395, R01AG068295, R01AG070915]; National Institute of
   Neurological Disorders and Stroke [R01NS100782]; National Cancer
   Institute [R01CA255840]; Ministry of Innovation and Technology of
   Hungary from the National Research, Development and Innovation Fund
   [TKP2021-NKTA-47]; National Cardiovascular Laboratory Program
   [RRF-2.3.1-21-2022-00003]; National Laboratory for Drug Research and
   Development (PharmaLab) by the Ministry of Innovation and Technology of
   Hungary from the National Research, Development and Innovation Fund
   [RRF-2.3.1-21-2022-00015]; National Research, Development and Innovation
   Fund of Hungary [135784]; European University for Well-Being (EUniWell)
   program [101004093/EUniWell/EAC-A02-2019/EAC-A02-2019-1]; New National
   Excellence Program of the Ministry for Culture and Innovation from the
   Source of the National Research, Development and Innovation Fund
   [EKOEP-2024-9, EKOEP-2024-2]
FX Open access funding provided by Semmelweis University. This work was
   supported by grants from the National Institute on Aging (RF1AG072295,
   R01AG055395, R01AG068295; R01AG070915), the National Institute of
   Neurological Disorders and Stroke (R01NS100782), and the National Cancer
   Institute (R01CA255840). AU was supported by TKP2021-NKTA-47,
   implemented with the support provided by the Ministry of Innovation and
   Technology of Hungary from the National Research, Development and
   Innovation Fund, financed under the TKP2021-NKTA funding scheme; by
   funding through the National Cardiovascular Laboratory Program
   (RRF-2.3.1-21-2022-00003) and by the National Laboratory for Drug
   Research and Development (PharmaLab, RRF- 2.3.1-21-2022-00015) provided
   by the Ministry of Innovation and Technology of Hungary from the
   National Research, Development and Innovation Fund; and Project no.
   135784 implemented with the support provided from the National Research,
   Development and Innovation Fund of Hungary, financed under the K20
   funding scheme and the European University for Well-Being (EUniWell)
   program (grant agreement number:
   101004093/EUniWell/EAC-A02-2019/EAC-A02-2019-1). AL and AU were
   supported by the EKOEP-2024-9 and EKOEP-2024-2, respectively, New
   National Excellence Program of the Ministry for Culture and Innovation
   from the Source of the National Research, Development and Innovation
   Fund. A5 Genetics Ltd (Kutaso, Hungary) provided computational
   infrastructure for the study. The funding sources had no role in the
   study design; in the collection, analysis, and interpretation of data;
   in the writing of the report; and in the decision to submit the article
   for publication. The content is solely the responsibility of the authors
   and does not necessarily represent the official views of the National
   Institutes of Health, the American Heart Associa- tion, or the
   Presbyterian Health Foundation. The 4.0 version of ChatGPT, developed by
   OpenAI, was used as a language tool to refine our writing and enhancing
   the clarity of our work.
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NR 205
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Z9 7
U1 5
U2 8
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 2509-2715
EI 2509-2723
J9 GEROSCIENCE
JI GeroScience
PD 2024 OCT 8
PY 2024
DI 10.1007/s11357-024-01375-x
EA OCT 2024
PG 22
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
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PM 39379738
OA hybrid
DA 2025-06-11
ER

PT J
AU Roberts, MJ
   Thackray, AE
   Wadley, AJ
   Alotaibi, TF
   Hunter, DJ
   Thompson, J
   Fujihira, K
   Miyashita, M
   Mastana, S
   Bishop, NC
   O'donnell, E
   Davies, MJ
   King, JA
   Yates, T
   Webb, D
   Stensel, DJ
AF Roberts, Matthew J.
   Thackray, Alice E.
   Wadley, Alex J.
   Alotaibi, Tareq F.
   Hunter, David J.
   Thompson, Julie
   Fujihira, Kyoko
   Miyashita, Masashi
   Mastana, Sarabjit
   Bishop, Nicolette C.
   O'donnell, Emma
   Davies, Melanie J.
   King, James A.
   Yates, Thomas
   Webb, David
   Stensel, David J.
TI Effect of Acute Walking on Endothelial Function and Postprandial Lipemia
   in South Asians and White Europeans
SO MEDICINE & SCIENCE IN SPORTS & EXERCISE
LA English
DT Article
DE EXERCISE; FLOW-MEDIATED DILATATION; METABOLIC SYNDROME; ETHNICITY
ID DISEASE RISK MARKERS; OXIDATIVE STRESS; CARDIOVASCULAR-DISEASE; VASCULAR
   DYSFUNCTION; BRACHIAL-ARTERY; EXERCISE; HEALTH
AB ROBERTS, M. J., A. E. THACKRAY, A. J. WADLEY, T. F. ALOTAIBI, D. J. HUNTER, J. THOMPSON, K. FUJIHIRA, M. MIYASHITA, S. MASTANA, N. C. BISHOP, E. ODONNELL, M. J. DAVIES, J. A. KING, T. YATES, D. WEBB, andD. J. STENSEL. Effect ofAcuteWalking on Endothelial Function and Postprandial Lipemia in South Asians and White Europeans. Med. Sci. Sports Exerc., Vol. 55, No. 5, pp. 794-802, 2023. Introduction: South Asians (SAs) have an elevated risk of cardiovascular disease (CVD) compared with White Europeans (WEs). Postprandial endothelial function (flow-mediated dilatation (FMD%)) in SA women and SA men with central obesity has not been investigated. Research in other populations has highlighted that a 1% higher FMD% is associated with a similar to 13% lower risk of future CVD events. We investigated whether FMD% and lipemia, twomarkers for CVD risk, were higher in SAs versusWEs, whether walking improved FMD% and lipemia, and if there were ethnic differences in the response. Methods: Lean premenopausal women (study 1; 12 SA, 12 WE) and men with central obesity (study 2; 15 SA, 15 WE) completed two 2-d trials. On day 1, participants walked for 60 min at 60% of their peak oxygen uptake or rested. On day 2, participants rested and consumed two high-fat meals over 8 h. Repeated ultrasound assessments of endothelial function and venous blood samples for CVD risk markers were taken. Results: Compared with WEs, SAs had lower postprandial FMD%(study 1, -1.32%; study 2, -0.54%) and higher postprandial triacylglycerol concentrations (study 1, 0.31 mmol center dot L-1 center dot h(-1); study 2, 0.55 mmol center dot L-1 center dot h(-1)). Walking improved postprandial FMD% (study 1, 1.12%; study 2, 0.94%) and resulted in no significant change or small reductions in postprandial triacylglycerol concentrations (study 1, -0.01 mmol center dot L-1 center dot h(-1); study 2, -0.25 mmol center dot L-1 center dot h(-1)). Exercise-induced changes in FMD% and triacylglycerol were consistent between ethnic groups. Conclusions: Walkingmitigated the adverse postprandial effect of a high-fat diet on FMD% to a similar extent in SA and WE women and men, even with no/small improvements in triacylglycerol. This study highlights the importance of exercise to clinically improve FMD% in SAs and WEs.
C1 [Roberts, Matthew J.; Thackray, Alice E.; Thompson, Julie; Mastana, Sarabjit; Bishop, Nicolette C.; O'donnell, Emma; Stensel, David J.] Loughborough Univ, Natl Ctr Sport & Exercise Med, Sch Sport Exercise & Hlth Sci, Loughborough, Leics, England.
   [Roberts, Matthew J.; Thackray, Alice E.; Bishop, Nicolette C.; O'donnell, Emma; Davies, Melanie J.; Yates, Thomas; Webb, David; Stensel, David J.] NIHR, Univ Hosp Leicester, Natl Hlth Serv Trust, Leicester Biomed Res Ctr, Leicester, England.
   [Roberts, Matthew J.; Thackray, Alice E.; Bishop, Nicolette C.; O'donnell, Emma; Davies, Melanie J.; King, James A.; Yates, Thomas; Webb, David; Stensel, David J.] Univ Leicester, Leicester, Leics, England.
   [Wadley, Alex J.] Univ Birmingham, Coll Life & Environm Sci, Sch Sport Exercise & Rehabil Sci, Birmingham, England.
   [Alotaibi, Tareq F.] King Saud bin Abdulaziz Univ Hlth Sci, Resp Therapy Dept, Riyadh, Saudi Arabia.
   [Alotaibi, Tareq F.] King Saud Bin Abdulaziz Univ Hlth Sci, King Abdullah Int Med Res Ctr, Riyadh, Saudi Arabia.
   [Thompson, Julie] Univ Hosp Leicester NHS Trust, Infirm Sq, Leicester, England.
   [Fujihira, Kyoko] Waseda Univ, Grad Sch Sport Sci, Tokorozawa, Japan.
   [Miyashita, Masashi; Stensel, David J.] Waseda Univ, Fac Sport Sci, Tokorozawa, Japan.
   [Davies, Melanie J.; Yates, Thomas; Webb, David] Univ Leicester, Leicester Diabet Res Ctr, Leicester, England.
   [Stensel, David J.] Loughborough Univ, Natl Ctr Sport & Exercise Med, Sch Sport Exercise & Hlth Sci, Loughborough LE11 3TU, England.
C3 Loughborough University; University of Leicester; University Hospitals
   of Leicester NHS Trust; University of Leicester; University of
   Birmingham; King Saud Bin Abdulaziz University for Health Sciences; King
   Saud Bin Abdulaziz University for Health Sciences; King Abdullah
   International Medical Research Center (KAIMRC); University Hospitals of
   Leicester NHS Trust; University of Leicester; Waseda University; Waseda
   University; University of Leicester; Loughborough University
RP Stensel, DJ (corresponding author), Loughborough Univ, Natl Ctr Sport & Exercise Med, Sch Sport Exercise & Hlth Sci, Loughborough LE11 3TU, England.
EM M.Roberts3@lboro.ac.uk; A.E.Thackray@lboro.ac.uk; A.J.Wadley@bham.ac.uk;
   alotaibita@ksau-hs.edu.sa; D.J.Hunter@lboro.ac.uk;
   julie.g.thompson@uhl-tr.nhs.uk; fujihira.k.ac@m.titech.ac.jp;
   m.miyashita@waseda.jp; S.S.Mastana@lboro.ac.uk; N.C.Bishop@lboro.ac.uk;
   E.ODonnell@lboro.ac.uk; melanie.davies@uhl-tr.nhs.uk;
   J.A.King@lboro.ac.uk; ty20@leicester.ac.uk; david.webb@uhl-tr.nhs.uk;
   D.J.Stensel@lboro.ac.uk
RI Davies, Melanie/AFA-4210-2022; King, James/AAG-7805-2021; Mastana,
   Sarabjit/A-1405-2011; Roberts, Matthew/JHT-6315-2023; Miyashita,
   Masashi/ABA-5423-2020; Thackray, Alice/G-7254-2015
OI Yates, Thomas/0000-0002-5724-5178; Roberts, Matthew/0000-0003-2952-103X;
   Fujihira, Kyoko/0000-0001-5015-572X; O'Donnell,
   Emma/0000-0002-4037-4213; Thackray, Alice/0000-0002-7800-3207; Bishop,
   Nicolette/0000-0001-6221-3907
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NR 36
TC 2
Z9 2
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0195-9131
EI 1530-0315
J9 MED SCI SPORT EXER
JI Med. Sci. Sports Exerc.
PD MAY
PY 2023
VL 55
IS 5
BP 794
EP 802
DI 10.1249/MSS.0000000000003098
PG 9
WC Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Sport Sciences
GA P7EB1
UT WOS:001052257200004
PM 36729923
OA Green Published
DA 2025-06-11
ER

PT J
AU Tesanovic, S
   Radman, M
   Tesanovic, D
   Erzen, DJ
   Hozo, I
AF Tesanovic, Sanda
   Radman, Maja
   Tesanovic, Desa
   Erzen, Dubravka Jurisic
   Hozo, Izet
TI Preliminary Report of Hypoglycemic Response in Obese Metabolic Syndrome
   Males Treated with Metformin after Weight Loss Intervention
SO COLLEGIUM ANTROPOLOGICUM
LA English
DT Article
DE obesity; cortisol; growth hormone
ID INSULIN-INDUCED HYPOGLYCEMIA; GROWTH-HORMONE; SECRETION; CORTISOL;
   RESISTANCE
AB We conducted this study to determine the degree of obesity influence on the hypoglycemic response of growth hormone and cortisol after weight loss of 5%. A total of 45 non-diabetic, male subjects followed in the outpatient endocrinological departments were divided into three groups comprising 15 subjects in each group, based upon body mass index (BMI) to healthy, overweight and obese group. Metformin was administered in the dose of 50 mg daily to the overweight and obese participants. Cortisol was measured at 0, 60 and 120 minutes. Growth hormone (GH) was measured at -15, 0, 30, 60, 90 and 120 minutes.Values of cortisol and GH were compared upon changes in hypothalamo-pituitary-adrenal (HPA) response to insulin induced hypoglycemia initially and after weight loss of 5% for overweight and obese participants.The BMI of the healthy group ranged 20.0-24.5 kg/m(2) (median: 22.8); overweight group ranged 25.9-29.7 kg/m(2) (median: 28.3); and obese group ranged 30.9-34.6 kg/m(2) (median: 32.6). There were no significant differencesof cortisol values among groups at 0 (chi(2)=2.0; p=0.365); 60 (chi(2)=0.754; P=0.686) and at 120 minutes (chi(2)=0.466; p=0.792). The comparisons among groups were significant for differences of GH values at -15 (chi(2)=25.0; p<0.01); 0 (chi(2)=16.2; p<0.01); 30 (chi(2)=16.2; p<0.01); 60 (chi(2)=32.8; p<0.01); 90 (chi(2)=30.2; p<0.01) and at 120 minutes (chi(2)=27.3; p<0.01).Healthy and obese subjects significantly differed in growth hormone response at -15 (Z=4.67; p<0.01); 0 (Z=3.83; p<0.01); 60 (Z=2.78; p =0.05); 90 (Z=4.67; p<0.01) and at 120 minutes (Z=4.23; p<0.01).Changes on the various levels of HPA axis, when it is activated by a stress as it is the case in insulin-induced hypoglycemia correspond to the degree of obesity. Weight loss of 5% was not enough for restoration of a normal stimulated growth hormone release and did not influence on the level of cortisol.
C1 [Tesanovic, Sanda] Dubrovnik Gen Hosp, Dept Endocrinol, Dubrovnik, Croatia.
   [Radman, Maja; Hozo, Izet] Univ Split, Split Univ Hosp Ctr, Dept Endocrinol, Split 21000, Croatia.
   [Tesanovic, Desa] Univ Zagreb, Sch Med, Zagreb 41001, Croatia.
   [Erzen, Dubravka Jurisic] Univ Rijeka, Rijeka Univ Hosp Ctr, Dept Endocrinol, Rijeka, Croatia.
C3 University of Split; University of Zagreb; University of Rijeka
RP Radman, M (corresponding author), Univ Split, Split Univ Hosp Ctr, Dept Endocrinol, Soltanska 1, Split 21000, Croatia.
EM maja.radman1@st.t-com.hr
RI Radman, Maja/H-2891-2017; Dubravka, Jurisic-Erzen/S-1769-2018
OI Dubravka, Jurisic-Erzen/0000-0002-6614-9778
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NR 20
TC 3
Z9 3
U1 0
U2 4
PU COLLEGIUM ANTROPOLOGICUM
PI ZAGREB
PA INST ANTHROPOLOGICAL RESEARCH, GAJEVA 32, PO BOX 290, HR-10000 ZAGREB,
   CROATIA
SN 0350-6134
J9 COLLEGIUM ANTROPOL
JI Coll. Anthropol.
PD JUN
PY 2013
VL 37
IS 2
BP 367
EP 371
PG 5
WC Anthropology
WE Social Science Citation Index (SSCI)
SC Anthropology
GA 196TW
UT WOS:000322801300006
PM 23940976
DA 2025-06-11
ER

PT J
AU Singer, M
AF Singer, Merrill
TI The biosocial health of US long haul truckers: Syndemics of the road
SO JOURNAL OF TRANSPORT & HEALTH
LA English
DT Article
ID WHOLE-BODY VIBRATION; METABOLIC SYNDROME; RISK-FACTORS; SLEEP-APNEA;
   CIGARETTE-SMOKING; NATIONAL-SURVEY; WORKING-CONDITIONS; DRIVER HEALTH;
   UNITED-STATES; STRESS
AB Introduction: Due to daily and enduring economic and other pressures, poor working conditions, and a common pattern of behaviors and practices, long-haul truck driving is a physiologically stressful and both biologically and psychologically challenging job that is not conducive to healthy living or routine healthcare seeking. The work context of this occupation fits the definition of a "risk environment," namely a space in which a variety of factors interact to increase the chances of harm occurring. While prior research on this population has tended to focus on one or two primary health conditions or separately review multiple health conditions as a consequence of specific trucker lifestyle and working conditions, newer models of health, like syndemic theory, consider synergistic interactions among comorbid diseases that are interconnected within a set of linked social determinants of health. This approach is concerned with assessing how intersecting living/working conditions promote the clustering and adverse interaction of diseases and other health factors. Methods: This paper reviews identified bodies of literature that address: the nature of the work conditions of long haul truckdrivers and the factors responsible for these conditions, the health risks associated with the conditions, and the potential syndemic interactions of diseases that are frequent in this population and pathways of disease interaction. Because of the multiple literatures involved the paper does not employ a systematic review approach. Setting: and Population: The paper focuses on long haul truck drivers-who may travel coast to coast remaining on the road for weeks and sometimes months at a time-in the U.S. Results: A number of likely syndemics common among long haul truck drivers are identified and assessed. This review affirms that a syndemics approach is well suited to the challenge of better understanding and improving worker health. A syndemics lens pushes researchers to develop a comprehensive biosocial picture of health in a population and to consider biosocial and multi-disease interventions. Conclusion: This paper employs a syndemics lens to review the key health risks of long haul truck drivers in the U.S., identify the factors increasing their behavioral and other health risks, and suggest likely synergistic health consequences in need of public health intervention. In light of the serious consequences of the health, social, and economic cost of syndemics of the road, there is a need for expanded attention to this issue in research, funding, and policy.
C1 [Singer, Merrill] Univ Connecticut, Dept Anthropol, Storrs, CT 06269 USA.
   [Singer, Merrill] 2207 Creighton Dr, Norman, OK 37071 USA.
C3 University of Connecticut
RP Singer, M (corresponding author), Univ Connecticut, Dept Anthropol, Storrs, CT 06269 USA.; Singer, M (corresponding author), 2207 Creighton Dr, Norman, OK 37071 USA.
EM Merrill.Singer@uconn.edu
OI Singer, Merrill/0000-0002-2040-4622
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NR 122
TC 0
Z9 0
U1 1
U2 2
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 2214-1405
J9 J TRANSP HEALTH
JI J. Transp. Health
PD FEB
PY 2025
VL 40
AR 101939
DI 10.1016/j.jth.2024.101939
EA NOV 2024
PG 14
WC Public, Environmental & Occupational Health; Transportation
WE Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; Transportation
GA M3R2U
UT WOS:001356745100001
DA 2025-06-11
ER

PT J
AU Wang, CX
   Min, RX
   Zhou, QL
   Qi, Y
   Ma, YL
   Zhang, XF
AF Wang, Caixia
   Min, Ruixue
   Zhou, Qilun
   Qi, Yue
   Ma, Yanli
   Zhang, Xiaofeng
TI Multiple health outcomes associated with algae and its extracts
   supplementation: An umbrella review of systematic reviews and
   meta-analyses
SO PHYTOTHERAPY RESEARCH
LA English
DT Review
DE algae; extracts; health; meta-analysis; metabolic syndrome; umbrella
   review
ID SPIRULINA SUPPLEMENTATION; IMPACT
AB Algae and its extracts, widely consumed as functional foods, offer numerous health benefits; however, a comprehensive systematic summary of clinical evidence is currently lacking. The study was to assess the available evidence and provide an accurate estimate of the overall effects of algae and its extracts supplementation on various health outcomes. The comprehensive searches in PubMed, Scopus, Embase, Web of Science, and the Cochrane Library until December 22, 2023 were implemented. The random-effects model was employed to pool the overall effect sizes (ESs) and the corresponding 95% confidence intervals (CIs) using Stata software. Moreover, detecting the methodological quality and evidence level of the eligible studies were employed by A Measurement Tool to Assess Systematic Review 2 (AMSTAR2) and the Grading of Recommendations Assessment Development and Evaluation. Ultimately, 25 articles covering 133 health outcomes were included in this umbrella review. The pooled results demonstrated that the algae and its extracts could significantly decrease body weight (ES = -1.65; 95% CI: -1.97, -1.34; p < 0.001), body mass index (BMI) (ES = -0.42; 95% CI: -0.78, -0.07; p = 0.020), waist circumference (WC) (ES = -1.40; 95% CI: -1.40, -1.39; p < 0.001), triglyceride (TG) (ES = -1.38; 95% CI: -2.15, -0.62; p < 0.001), total cholesterol (TC) (ES: -1.40; 95% CI: -2.09, -0.72; p < 0.001), very low-density lipoprotein cholesterol (VLDL-C) (ES = -7.85; 95% CI: -8.55, -7.15; p < 0.001), fasting blood glucose (ES = -2.68; 95% CI: -4.57, -0.79; p = 0.005), glycated hemoglobin (HbA1c) (ES = -0.15; 95% CI: -0.24, -0.07; p < 0.001), systolic blood pressure (ES = -3.21; 95% CI: -5.25, -1.17; p = 0.002), diastolic blood pressure (ES = -3.84; 95% CI: -7.02, -0.65; p = 0.018), alanine transaminase (ES = -0.42; 95% CI: -0.70, -0.14; p = 0.003), and alkaline phosphatase (ES = -0.54; 95% CI: -0.99, -0.10; p = 0.017). Due to the limited number of studies, no benefit was displayed on markers of inflammation and oxidative stress. Considering the suboptimal quality of studies and the insufficient articles pertaining to certain outcomes, further well-designed research is imperative to substantiate the observed findings.
C1 [Wang, Caixia; Min, Ruixue; Zhou, Qilun; Qi, Yue; Zhang, Xiaofeng] Zhengzhou Univ, Coll Publ Hlth, Dept Nutr & Food Hyg, Zhengzhou, Henan, Peoples R China.
   [Ma, Yanli] Nanyang Inst Technol, Henan Key Lab Zhang Zhongjing Formulae & Herbs Imm, Nanyang, Peoples R China.
C3 Zhengzhou University; Nanyang Institute of Technology
RP Zhang, XF (corresponding author), Zhengzhou Univ, Coll Publ Hlth, Dept Nutr & Food Hyg, Zhengzhou, Henan, Peoples R China.
EM zhangxf@zzu.edu.cn
RI wang, caixia/IUO-6154-2023
FU Major Collaborative Innovation Project of Nanyang City, Henan Province,
   China
FX Henan Institute of Science and Technology, Grant/Award Number:
   152102310260; Major Collaborative Innovation Project of Nanyang City,
   Henan Province, China, Grant/Award Number: 21XTCX12005.r No Statement
   Available
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NR 91
TC 1
Z9 1
U1 3
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0951-418X
EI 1099-1573
J9 PHYTOTHER RES
JI Phytother. Res.
PD NOV
PY 2024
VL 38
IS 11
BP 5162
EP 5183
DI 10.1002/ptr.8305
EA AUG 2024
PG 22
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA M0F5A
UT WOS:001294100700001
PM 39161296
OA Bronze
DA 2025-06-11
ER

PT J
AU de Leeuw, MJ
   Böhmer, MN
   Leening, MJG
   Kors, JA
   Bindels, PJE
   Oppewal, A
   Maes-Festen, DAM
AF de Leeuw, M. J.
   Bohmer, M. N.
   Leening, M. J. G.
   Kors, J. A.
   Bindels, P. J. E.
   Oppewal, A.
   Maes-Festen, D. A. M.
TI Feasibility and findings of electrocardiogram recording in older adults
   with intellectual disabilities: results of the Healthy Ageing and
   Intellectual Disabilities study
SO JOURNAL OF INTELLECTUAL DISABILITY RESEARCH
LA English
DT Article
DE aged; electrocardiography; feasibility studies; intellectual disability
ID UNRECOGNIZED MYOCARDIAL-INFARCTION; CORONARY-HEART-DISEASE;
   ATRIAL-FIBRILLATION; CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME;
   CLINICAL-PRACTICE; QTC PROLONGATION; COMPUTER-PROGRAM; CARDIAC DEATH;
   PRIMARY-CARE
AB BackgroundOlder adults with intellectual disabilities (ID) have a high risk of cardiovascular diseases (CVD). At the same time, challenging diagnostic work-up increases the likelihood of underdiagnosis of CVD in this population. To limit this underdiagnosis, it would be beneficial to use objective measures such as the electrocardiogram (ECG). However, little is known about the feasibility of ECG recording and the prevalence of ECG abnormalities in this population. Therefore, the aims of this study were to investigate the feasibility of resting ECG recording, to study the prevalence of ECG abnormalities, and to compare the frequency of ECG abnormalities with medical records in older adults with ID.MethodA cross-sectional study was performed within a cohort of older adults (>= 60 years) with ID as part of the Healthy Ageing and Intellectual Disabilities (HA-ID) study. A resting 12-lead ECG was attempted, and the ECG recording was considered feasible if the recording could be made and if the ECG could be interpreted by a cardiologist and the Modular ECG Analysis System (MEANS). ECGs were assessed for the presence of ECG abnormalities and medical record review was performed. If the cardiologist or MEANS concluded that there was evidence of myocardial infarction, atrial fibrillation or QTc prolongation on the ECG in the absence of this ECG diagnosis in the participant's medical record, this was classified as a previously undiagnosed ECG diagnosis.ResultsECG recording was feasible in 134 of the 200 participants (67.0%). Of these 134 participants (70.6 +/- 5.8 years; 52.2% female), 103 (76.9%) had one or more ECG abnormality, with the most prevalent being prolonged P-wave duration (27.6%), QTc prolongation (18.7%), minor T-wave abnormalities (17.9%), first degree atrioventricular block (12.7%) and myocardial infarction (6.7%). Eight out of 9 (88.9%) myocardial infarctions and all cases of (significant) QTc prolongation (100%) were previously undiagnosed.ConclusionsThis study showed that ECG recording is feasible in the majority of older adults with ID and revealed a substantial underdiagnosis of ECG abnormalities. These results stress the importance of ECG recording and warrant further research into the yield of opportunistic ECG screening in older adults with ID.
C1 [de Leeuw, M. J.; Bohmer, M. N.; Bindels, P. J. E.; Oppewal, A.; Maes-Festen, D. A. M.] Erasmus MC Univ Med Ctr Rotterdam, Dept Gen Practice, Intellectual Disabil Med, POB 2040, NL-3000 CA Rotterdam, Netherlands.
   [Leening, M. J. G.] Erasmus MC Univ Med Ctr Rotterdam, Dept Epidemiol, Rotterdam, Netherlands.
   [Leening, M. J. G.] Erasmus MC Univ Med Ctr Rotterdam, Dept Cardiol, Rotterdam, Netherlands.
   [Kors, J. A.] Erasmus MC Univ Med Ctr Rotterdam, Dept Med Informat, Rotterdam, Netherlands.
C3 Erasmus University Rotterdam; Erasmus MC; Erasmus University Rotterdam;
   Erasmus MC; Erasmus University Rotterdam; Erasmus MC; Erasmus University
   Rotterdam; Erasmus MC
RP de Leeuw, MJ (corresponding author), Erasmus MC Univ Med Ctr Rotterdam, Dept Gen Practice, Intellectual Disabil Med, POB 2040, NL-3000 CA Rotterdam, Netherlands.
EM m.j.deleeuw@erasmusmc.nl
RI Bohmer, Mylene/IVH-5572-2023; Maes-Festen, Dederieke/P-8654-2016;
   Oppewal, Alyt/AFN-7707-2022; de Leeuw, Marleen/JRY-3325-2023
OI Leening, Maarten J. G./0000-0002-4143-4839; Oppewal,
   Alyt/0000-0001-6630-8807; Maes-Festen, Dederieke/0000-0002-7613-0720;
   Bindels, Patrick/0000-0001-5941-4820; de Leeuw,
   Marleen/0000-0002-6357-6213
FU Abrona; Amarant; Ipse de Bruggen; Department of General Practice,
   Intellectual Disability Medicine of the Erasmus MC - University Medical
   Center Rotterdam
FX The follow-up of the HA-ID study is financially supported by three Dutch
   care organisations (Abrona, Amarant and Ipse de Bruggen) and the
   Department of General Practice, Intellectual Disability Medicine of the
   Erasmus MC - University Medical Center Rotterdam. The funding sources
   were not involved in the conduct of the research and/or preparation of
   the manuscript.
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NR 70
TC 1
Z9 1
U1 1
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0964-2633
EI 1365-2788
J9 J INTELL DISABIL RES
JI J. Intell. Disabil. Res.
PD DEC
PY 2024
VL 68
IS 12
BP 1344
EP 1357
DI 10.1111/jir.13181
EA AUG 2024
PG 14
WC Education, Special; Genetics & Heredity; Clinical Neurology; Psychiatry;
   Rehabilitation
WE Social Science Citation Index (SSCI)
SC Education & Educational Research; Genetics & Heredity; Neurosciences &
   Neurology; Psychiatry; Rehabilitation
GA L1H0Z
UT WOS:001291109200001
PM 39148342
OA hybrid
DA 2025-06-11
ER

PT J
AU Li, XY
   Zhou, WW
   Hu, GS
AF Li, Xinyuan
   Zhou, Weiwei
   Hu, Guangsheng
TI The association between non-alcoholic fatty liver disease and urinary
   incontinence among adult females in the United States
SO BMC PUBLIC HEALTH
LA English
DT Article
DE Urinary incontinence; NAFLD; NHANES; Cross-sectional; United States
ID RISK-FACTORS; METABOLIC SYNDROME; PREVALENCE; WOMEN; OBESITY; MEN;
   GLUCOSE; PEOPLE; LEVEL
AB Background and objectives Non-alcoholic fatty liver disease (NAFLD) and urinary incontinence (UI) are both highly prevalent and age-related diseases. Nevertheless, the link between NAFLD and UI is unclear. Hence, the study was designed to evaluate the association between the NAFLD and UI (including UI types) in a nationally representative sample of United States (US) female adults. Methods We conducted this study used data from U.S. female adults in the National Health and Nutrition Examination Survey (NHANES) 2017-March 2020 (pre-pandemic) cycles. The diagnosis of NAFLD is based on Vibration controlled transient elastography (VCTE) and absence of know liver diseases and significant alcohol consumption. The diagnosis and types of UI were assessment using a self-report questionnaire. Multivariable logistic regression models were used to analyze the association between NALFD and UI. Stratified analyses based on age, obesity, race, educational level, married status, PIR, and smoking status were conducted. Results Of the 2149 participants, the mean (95% CI) age was 53.9 (52.7-55.0), 686 (61.1%) were Non-Hispanic White. UI was significantly more common in participants with NAFLD [490 (64.7%)] than those without NAFLD [552 (44.9%)]. Adjusted for age, race/ethnicity, marital status, educational level, family poverty income ratio (PIR) status, alanine aminotransferase (ALT), aspartate aminotransferase (AST), smoking status, obesity, type 2 diabetes mellitus (T2DM), hypertension and insulin resistance (IR) in a multivariable logistic regression model, NALFD were associated with UI [OR: 1.93, 95%CI 1.23-3.02, P = 0.01] and urge UI [OR: 1.55, 95%CI 1.03-2.33, P = 0.03], while patients with NAFLD did not show an increased odds in stress UI and mixed UI when compared with those without NAFLD subject (P > 0.05). In the subgroup analyses, NAFLD remained significantly associated with UI, particularly among those participants without obesity (OR: 2.69, 95% CI 1.84-4.00) and aged >= 60 years (OR: 2.20, 95% CI 1.38-3.51). Conclusions Among US female adults, NAFLD has a strong positive correlation with UI. Given that NAFLD is a modifiable disease, these results may help clinicians to target female patients with NAFLD for treatments and interventions that may help prevent the occurrence of UI and reduce the symptoms of UI.
C1 [Li, Xinyuan; Zhou, Weiwei; Hu, Guangsheng] Univ South China, Affiliated Hosp 1, Dept Gastroenterol, Hengyang 421001, Hunan, Peoples R China.
C3 University of South China
RP Zhou, WW; Hu, GS (corresponding author), Univ South China, Affiliated Hosp 1, Dept Gastroenterol, Hengyang 421001, Hunan, Peoples R China.
EM zw137543@163.com; 360680725@qq.com
RI Li, Xinyuan/Z-6299-2019
FU National Key Research and Development Program of China
FX The authors thank the staff of the National Health and Nutrition
   Examination in this study for their indispensable contribution.
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NR 41
TC 1
Z9 1
U1 3
U2 16
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2458
J9 BMC PUBLIC HEALTH
JI BMC Public Health
PD MAY 22
PY 2024
VL 24
IS 1
AR 1373
DI 10.1186/s12889-024-18578-8
PG 8
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA RR7P9
UT WOS:001229457400002
PM 38778285
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Moleda, P
   Fronczyk, A
   Safranow, K
   Majkowska, L
AF Moleda, Piotr
   Fronczyk, Aneta
   Safranow, Krzysztof
   Majkowska, Lilianna
TI Is Uric Acid a Missing Link between Previous Gestational Diabetes
   Mellitus and the Development of Type 2 Diabetes at a Later Time of Life?
SO PLOS ONE
LA English
DT Article
ID ACTIVATED PROTEIN-KINASE; OXIDATIVE STRESS; ENDOTHELIAL DYSFUNCTION;
   METABOLIC SYNDROME; RISK; INSULIN; HYPERURICEMIA; INFLAMMATION;
   ASSOCIATION; GLUCOSE
AB Introduction
   A high level of uric acid (UA) is a strong, independent risk factor for type 2 diabetes mellitus. The relationship between UA levels and the development of type 2 diabetes in women with previous gestational diabetes mellitus (pGDM) remains unclear. The aim of study was to evaluate the UA levels in pGDM women in relation to their current nutritional status and carbohydrate metabolism.
   Material and Methods
   199 women with pGDM diagnoses based on oral glucose tolerance tests (OGTTs) 5-12 years previously and a control group of 50 women without pGDM. The assessment included anthropometric parameters, body composition (Tanita SC-330S), current OGTT, insulin resistance index (HOMA-IR), beta-cell function (HOMA-%B), HbA1c, lipids, and uric acid.
   Results
   No differences between groups were found in terms of age, time from the index pregnancy, anthropometric parameters, lipids or creatinine levels. The incidences of overweight and obesity were similar. Carbohydrate abnormalities were more frequent in the pGDM group than the control group (43.2% vs 12.0% p<0.001). The women with pGDM had significantly higher fasting glucose, HbA1c, glucose and insulin levels in the OGTTs, but similar HOMA-IR values. Their UA levels were significantly higher (258 +/- 58 vs 230 +/- 50 mu mol/L, p<0.005) and correlated with BMI and the severity of carbohydrate disorders. The normal weight and normoglycemic pGDM women also demonstrated higher UA levels than a similar control subgroup (232 +/- 48 vs 208 +/- 48 mu mol/L, p<0.05). Multivariate analysis revealed significant correlations of UA level with BMI (beta = 0.38, 95% CI 0.25-0.51, p<0.0001), creatinine level (beta = 0.23, 95% CI 0.11-0.35, p<0.0005), triglycerides (beta = 0.20, 95% CI 0.07-0.33, p<0.005) and family history of diabetes (beta = 0.13, 95% CI 0.01-0.25, p<0.05). In logistic regression analysis, the association between higher UA level (defined as value >= 297 mu mol/L) and presence of any carbohydrate metabolism disorder (IFG, IGT or diabetes) was statistically significant (odds ratio 3.62 [95% CI 1.8-7.3], p<0.001).
   Conclusions
   Higher UA levels may be associated with the development of type 2 diabetes in pGDM women, also in these with normal body weights.
C1 [Moleda, Piotr; Fronczyk, Aneta; Majkowska, Lilianna] Pomeranian Med Univ, Dept Diabetol & Internal Med, Szczecin, Poland.
   [Safranow, Krzysztof] Pomeranian Med Univ, Dept Biochem & Med Chem, Szczecin, Poland.
C3 Pomeranian Medical University; Pomeranian Medical University
RP Moleda, P (corresponding author), Pomeranian Med Univ, Dept Diabetol & Internal Med, Szczecin, Poland.
EM pmoleda@wp.pl
RI Majkowska, Lilianna/O-5016-2014; Fronczyk, Aneta/N-2417-2014; Moleda,
   Piotr/A-6852-2015; Safranow, Krzysztof/B-5127-2015
OI Moleda, Piotr/0000-0002-1148-5483; Safranow,
   Krzysztof/0000-0001-9415-2758
FU Ministry of Science and Higher Education [N 402 069 32/2047]
FX This work was supported by a scientific grant from the Ministry of
   Science and Higher Education as research project no. N 402 069 32/2047
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NR 39
TC 12
Z9 13
U1 0
U2 9
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAY 11
PY 2016
VL 11
IS 5
AR e0154921
DI 10.1371/journal.pone.0154921
PG 11
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA DM8CD
UT WOS:000376587300054
PM 27166795
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Matsushima, S
   Kinugawa, S
   Yokota, T
   Inoue, N
   Ohta, Y
   Hamaguchi, S
   Tsutsui, H
AF Matsushima, Shouji
   Kinugawa, Shintaro
   Yokota, Takashi
   Inoue, Naoki
   Ohta, Yukihiro
   Hamaguchi, Sanae
   Tsutsui, Hiroyuki
TI Increased myocardial NAD(P)H oxidase-derived superoxide causes the
   exacerbation of postinfarct heart failure in type 2 diabetes
SO AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
LA English
DT Article
DE diabetes; heart failure; remodeling; antioxidants; free radicals
ID LEFT-VENTRICULAR DYSFUNCTION; OXIDATIVE STRESS; NADPH OXIDASE;
   ANGIOTENSIN-II; ENDOTHELIAL DYSFUNCTION; INSULIN-RESISTANCE; METABOLIC
   SYNDROME; INFARCTION; MICE; ACTIVATION
AB Matsushima S, Kinugawa S, Yokota T, Inoue N, Ohta Y, Hamaguchi S, Tsutsui H. Increased myocardial NAD(P)H oxidase-derived superoxide causes the exacerbation of postinfarct heart failure in type 2 diabetes. Am J Physiol Heart Circ Physiol 297: H409-H416, 2009. First published May 22, 2009; doi: 10.1152/ajpheart.01332.2008.-Type 2 diabetes adversely affects the outcomes in patients with myocardial infarction (MI), which is associated with the development of left ventricular (LV) failure. NAD(P)H oxidase-derived superoxide (O-2(-)) production is increased in type 2 diabetes. However, its pathophysiological significance in advanced post-MI LV failure associated with type 2 diabetes remains unestablished. We thus hypothesized that an inhibitor of NAD(P)H oxidase activation, apocynin, could attenuate the exacerbated LV failure after MI in high-fat diet (HFD)-induced obese mice with type 2 diabetes. Male C57BL/6J mice were fed on either HFD or normal diet (ND) for 8 wk. At 4 wk of feeding, MI was created in mice by ligating the left coronary artery. HFD-fed MI mice were treated with either 10 mmol/l apocynin or vehicle. HFD + MI had significantly greater LV end-diastolic diameter (LVEDD; 5.7 +/- 0.1 vs. 5.3 +/- 0.2 mm), end-diastolic pressure (12 +/- 2 vs. 8 +/- 1 mmHg), and lung weight/tibial length (10.1 +/- 0.3 vs. 8.7 +/- 0.7 mg/mm) than ND + MI, which was accompanied by an increased interstitial fibrosis of non-infarcted LV. Treatment of HFD (MI with apocynin significantly decreased LVEDD (5.4 +/- 0.1 mm), LV end-diastolic pressure (9.7 +/- 0.8 mmHg), lung weight/tibial length (9.0 +/- 0.3 mg/mm), and concomitantly interstitial fibrosis of noninfarcted LV to the ND + MI level without affecting body weight, glucose metabolism, and infarct size. NAD(P)H oxidase activity and O-2(-) (production were increased in noninfarcted LV tissues from HFD + MI, both of which were attenuated by apocynin to the ND + MI level. Type 2 diabetes was associated with the exacerbation of LV failure after MI via increasing NAD(P)H oxidase-derived O-2(-), which may be a novel important therapeutic target in advanced heart failure with diabetes.
C1 [Matsushima, Shouji; Kinugawa, Shintaro; Yokota, Takashi; Inoue, Naoki; Ohta, Yukihiro; Hamaguchi, Sanae; Tsutsui, Hiroyuki] Hokkaido Univ, Grad Sch Med, Dept Cardiovasc Med, Kita Ku, Sapporo, Hokkaido 0608638, Japan.
C3 Hokkaido University
RP Kinugawa, S (corresponding author), Hokkaido Univ, Grad Sch Med, Dept Cardiovasc Med, Kita Ku, Kita 15,Nishi 7, Sapporo, Hokkaido 0608638, Japan.
EM tuckahoe@med.hokudai.ac.jp
RI matsushima, shouji/IUO-9529-2023; Tsutsui, Hiroyuki/A-4070-2012;
   Kinugawa, Shintaro/E-1268-2012; Inoue, Naoki/AAG-5171-2019
FU Ministry of Education, Science, and Culture [18790487, 17390223];
   Grants-in-Aid for Scientific Research [18790487, 17390223] Funding
   Source: KAKEN
FX This study was supported in part by grants from the Ministry of
   Education, Science, and Culture (18790487, 17390223).
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NR 45
TC 41
Z9 44
U1 0
U2 4
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0363-6135
EI 1522-1539
J9 AM J PHYSIOL-HEART C
JI Am. J. Physiol.-Heart Circul. Physiol.
PD JUL
PY 2009
VL 297
IS 1
BP H409
EP H416
DI 10.1152/ajpheart.01332.2008
PG 8
WC Cardiac & Cardiovascular Systems; Physiology; Peripheral Vascular
   Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Physiology
GA 464GI
UT WOS:000267492900048
PM 19465539
DA 2025-06-11
ER

PT J
AU Gokdemir, I
   Bezen, D
   Dikker, O
   Dursun, H
   Dag, H
AF Gokdemir, Irem
   Bezen, Digdem
   Dikker, Okan
   Dursun, Hasan
   Dag, Huseyin
TI Evaluation of the Relationship Between Adropin Levels and Blood Pressure
   in Obese Adolescents
SO IRANIAN JOURNAL OF PEDIATRICS
LA English
DT Article
DE Adropin; Blood Pressure; Obesity; Adolescents
ID VITAMIN-D STATUS; SERUM ADROPIN; RISK-FACTORS; INSULIN-RESISTANCE;
   METABOLIC SYNDROME; OXIDATIVE STRESS; NITRIC-OXIDE; PROTEIN; PLASMA;
   HEART
AB Background: Adropin is a bioactive protein that maintains energy balance through the metabolism of glucose and lipids. Adropin is associated with blood pressure, endothelial function, and glucose metabolism, according to reported studies. High blood pressure is one of the complications of obesity.
   Objectives: Our study investigated the relationship between adropin levels and systolic and diastolic blood pressure in obese adolescents.
   Methods: The study was conducted with a total of 88 adolescents, 45 females and 43 males, aged 10 - 18 years. The mean age of the participants was 13.79 +/- 1.98 years. Participants were divided into two groups: "obese" (n = 61) and "control" (n = 27). Adolescents with a body mass index (BMI) above the 95% percentile for age, gender, and race were defined as "obese." The control group comprised adolescents with a body mass index between the 5th and 85th percentiles. A sample was taken from the forearm pit of the subjects after fasting for at least 12 hours for the determination of glucose, insulin, urea, creatinine, aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma-glutamyl transferase (GGT), C- reactive protein (CRP), total cholesterol, low-density lipoprotein-cholesterol (LDL-cholesterol), high-density lipoprotein- cholesterol (HDL- cholesterol), triglyceride, thyroid-stimulating hormone (TSH), free T4 (fT4), and 25-hydroxyvitamin D3. In both groups, systolic and diastolic blood pressures were assessed using an aneroid manometer and a suitable cuff after subjects had rested for at least 10 minutes in the outpatient clinic. The following formula determined the homeostatic model of assessment for insulin resistance (HOMA-IR): fasting insulin (uIU/mL) x fasting glucose (mg/dL) /405. An enzyme-linked immunosorbent assay (ELISA) kit was used to measure adropin levels.
   Results: The insulin, HOMA-IR, AST, ALT, GGT, CRP, triglyceride, and LDL-cholesterol levels of adolescents in the obese group were statistically significantly higher than those in the control group (P < 0.05). HDL-cholesterol and 25-hydroxyvitamin D3 levels of adolescents in the obese group were statistically significantly lower than those of the control group (P < 0.05). There was no statistically significant difference between groups in glucose, urea, creatinine, total cholesterol, TSH, fT4, and adropin levels (P > 0.05). In the obese group, there was an inverse and statistically significant correlation between adropin level and diastolic blood pressure (P: 0.029; P < 0.05).
   Conclusions: We found an inverse relationship between adropin levels and DBP but no relationship between adropin levels and SBP in obese adolescents.
C1 [Gokdemir, Irem; Dursun, Hasan; Dag, Huseyin] Univ Hlth Sci, Istanbul Prof Dr Cemil Tascioglu City Hosp, Dept Pediat, Istanbul, Turkiye.
   [Bezen, Digdem] Univ Hlth Sci, Istanbul Prof Dr Cemil Tascioglu City Hosp, Dept Pediat, Pediat Endocrinol, Istanbul, Turkiye.
   [Dikker, Okan] Univ Hlth Sci, Istanbul Prof Dr Cemil Tascioglu City Hosp, Dept Med Biochem, Istanbul, Turkiye.
   [Dag, Huseyin] Istanbul Univ, Adolesance Hlth, Inst Child Hlth, Dept Pediat Basic Sci, Istanbul, Turkiye.
C3 University of Health Sciences Turkey; University of Health Sciences
   Turkey; University of Health Sciences Turkey; Istanbul University
RP Dag, H (corresponding author), Univ Hlth Sci, Istanbul Prof Dr Cemil Tascioglu City Hosp, Dept Pediat, Istanbul, Turkiye.
EM huseyindag2003@gmail.com
RI Dağ, Hüseyin/AEL-6162-2022
OI Dag, Huseyin/0000-0001-7596-7687
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NR 43
TC 0
Z9 0
U1 0
U2 0
PU BRIEFLAND
PI Shertogenbosch
PA 25 Derde Morgen, Shertogenbosch, NETHERLANDS
SN 2008-2142
EI 2008-2150
J9 IRAN J PEDIATR
JI Iran. J. Pediatr.
PD DEC
PY 2023
VL 33
IS 6
AR e139957
DI 10.5812/ijp-139957
PG 10
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA IT2L7
UT WOS:001168518000010
OA gold
DA 2025-06-11
ER

PT J
AU Sharma, P
   Yadav, RK
   Khadgawat, R
   Dada, R
AF Sharma, Piyush
   Yadav, Raj Kumar
   Khadgawat, Rajesh
   Dada, Rima
TI A 12-Week Yoga-Based Lifestyle Intervention Might Positively Modify
   Cellular Aging in Indian Obese Individuals: A Randomized-Controlled
   Trial
SO JOURNAL OF INTEGRATIVE AND COMPLEMENTARY MEDICINE
LA English
DT Article
DE aging; obesity; telomere; telomerase; yoga
ID LEUKOCYTE TELOMERE LENGTH; CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME;
   PHYSICAL-ACTIVITY; OXIDATIVE STRESS; RISK-FACTORS; OVERWEIGHT; EXERCISE;
   INFLAMMATION; ASSOCIATION
AB Background: Telomeres and telomerase are considered cardinal biomarkers of cellular aging. Shorter telomeres and low telomerase activity have been associated with obesity and accelerated aging.Objective: To compare the effects of a yoga-based lifestyle intervention (YBLI) with the standard of care (SOC) on cellular aging by estimating telomere length (TL) and telomerase activity in obesity.Design and setting: A parallel, two-arm, randomized-controlled trial was conducted at the Integral Health Clinic, Department of Physiology, All India Institute of Medical Sciences, New Delhi, from March 2017 to October 2019.Participants: Obese (n = 72), body mass index (BMI), 25-35 kg/m(2), aged 20-45 years, male (21), and female (51).Intervention: Seventy-two obese participants were randomized to receive either a 12-week SOC (n = 36) or YBLI (n = 36). SOC included management of obesity as per Indian guidelines including a hypocaloric individualized diet and physical activity. The pretested YBLI included asana (physical postures), pranayama (breathing exercises), and meditation.Methods: Blood samples were collected from both the groups at baseline, 2, 4, and 12 weeks. DNA was extracted from peripheral blood mononuclear cells. TL was measured by quantitative PCR, and serum telomerase levels by immunoassay.Outcome measures: Primary outcome measures were the changes in the TL and telomerase levels between the two groups at week 12. Secondary outcome measures were the changes in TL and telomerase, and anthropometric parameters (body weight, BMI, waist-to-hip ratio) at 2, 4, and 12 weeks of intervention in both SOC and YBLI groups.Results: There were no significant changes in TL and telomerase levels between the groups at week 12. The TL was significantly greater in the YBLI group versus the SOC group (p < 0.0001) at 2 weeks. The anthropometric and physiological parameters were influenced positively by both SOC and YBLI.Conclusion: The study did not meet the primary objective, although the results are suggestive of a positive impact of YBLI on aging in obesity as noted within the YBLI group. However, the results should be interpreted carefully, and in the light of other published data. Larger studies to better understand the possible positive benefits of YBLI on cellular aging are recommended. Clinical Trail Registration No. CTRI/2016/08/007136.
C1 [Sharma, Piyush; Yadav, Raj Kumar] All India Inst Med Sci, Dept Physiol, Integral Hlth & Wellness Clin, New Delhi, India.
   [Khadgawat, Rajesh] All India Inst Med Sci, Dept Endocrinol Metab & Diabet, New Delhi, India.
   [Dada, Rima] All India Inst Med Sci, Dept Anat, New Delhi, India.
   [Yadav, Raj Kumar] All India Inst Med Sci, Dept Physiol, Integral Hlth & Wellness Clin, New Delhi 110029, India.
C3 All India Institute of Medical Sciences (AIIMS) New Delhi; All India
   Institute of Medical Sciences (AIIMS) New Delhi; All India Institute of
   Medical Sciences (AIIMS) New Delhi; All India Institute of Medical
   Sciences (AIIMS) New Delhi
RP Yadav, RK (corresponding author), All India Inst Med Sci, Dept Physiol, Integral Hlth & Wellness Clin, New Delhi 110029, India.
EM raj3kr@gmail.com
RI Sharma, Piyush/LJL-6107-2024; Yadav, Raj Kumar/AFT-0686-2022
OI Yadav, Raj Kumar/0000-0002-5066-7028; Sharma, Dr.
   Piyush/0000-0002-8705-8699
FU AIIMS, New Delhi; Indian Council of Medical Research, Government of
   India
FX The authors extend their sincere thanks to Dr. V. Sreenivas, Professor
   (superannuated) Department of Biostatistics, AIIMS, New Delhi, to decide
   the optimal sample size for the study and for providing the
   randomization sequence codes, Ms. Varsha Saini (Yoga therapist, Central
   Council for Research in Yoga and Naturopathy), and Dr. Pragati Pragya
   (Clinical Nutritionist) for providing yoga training and dietary advice
   to the study participants, respectively. Dr. Vishwajeet Singh
   Scientist-III (Biostatistics) Department of Geriatric Medicine, AIIMS,
   New Delhi, and Ms. Nandita Gupta (Dr. Akhilesh Das Gupta Institute of
   Technology and Management, New Delhi) for helping in the data analysis.
   The authors are also grateful to the AIIMS, New Delhi, and the Indian
   Council of Medical Research, Government of India, for providing
   financial support. Most importantly, the authors sincerely acknowledge
   all the study participants.
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NR 58
TC 3
Z9 4
U1 2
U2 11
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 2768-3605
EI 2768-3613
J9 J INTEGR COMPLEMENT
JI J. Integr. Complement. Med.
PD FEB 1
PY 2022
VL 28
IS 2
BP 168
EP 178
DI 10.1089/jicm.2021.0215
EA JAN 2022
PG 11
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA 6R3NN
UT WOS:000838976400001
PM 35167359
DA 2025-06-11
ER

PT J
AU Rodenbeck, SD
   Zarse, CA
   McKenney-Drake, ML
   Bruning, RS
   Sturek, M
   Chen, NX
   Moe, SM
AF Rodenbeck, Stacey Dineen
   Zarse, Chad A.
   McKenney-Drake, Mikaela L.
   Bruning, Rebecca S.
   Sturek, Michael
   Chen, Neal X.
   Moe, Sharon M.
TI Intracellular calcium increases in vascular smooth muscle cells with
   progression of chronic kidney disease in a rat model
SO NEPHROLOGY DIALYSIS TRANSPLANTATION
LA English
DT Article
DE calcium signaling; cell phenotype; chronic kidney disease; rat model;
   vascular smooth muscle cells
ID MINERAL-BONE DISORDER; CHRONIC-RENAL-FAILURE; ARTERIAL MEDIAL
   CALCIFICATION; SARCOPLASMIC-RETICULUM; OXIDATIVE STRESS;
   HEMODIALYSIS-PATIENTS; METABOLIC SYNDROME; SECONDARY
   HYPERPARATHYROIDISM; VENTRICULAR HYPERTROPHY; IMPAIRED PHAGOCYTOSIS
AB Background: Vascular smooth muscle cells (VSMCs) exhibit phenotypic plasticity, promoting vascular calcification and increasing cardiovascular risk. Changes in VSMC intracellular calcium ([Ca2+](i)) are a major determinant of plasticity, but little is known about changes in [Ca2+](i) in chronic kidney disease (CKD). We have previously demonstrated such plasticity in aortas fromour rat model of CKD and therefore sought to examine changes in [Ca2+](i) during CKD progression.
   Materials and Methods: We examined freshly isolated VSMCs from aortas of normal rats, Cy/+ rats (CKD) with early and advanced CKD, and advanced CKD rats treated without and with 3% calcium gluconate (CKD + Ca2+) to lower parathyroid hormone (PTH) levels. [Ca2+](i) was measured with fura-2.
   Results: Cy/+ rats developed progressive CKD, as assessed by plasma levels of blood urea nitrogen, calcium, phosphorus, parathyroid hormone and fibroblast growth factor 23. VSMCs isolated from rats with CKD demonstrated biphasic alterations in resting [Ca2+](i): VSMCs from rats with early CKD exhibited reduced resting [Ca2+](i), while VSMCs from rats with advanced CKD exhibited elevated resting [Ca2+](i). Caffeine-induced sarcoplasmic reticulum (SR) Ca2+ store release was modestly increased in early CKD and was more drastically increased in advanced CKD. The advanced CKD elevation in SR Ca2+ store release was associated with a significant increase in the activity of the sarco-endoplasmic reticulum Ca2+ ATPase (SERCA); however, SERCA2a protein expression was decreased in advanced CKD. Following SR Ca2+ store release, recovery of [Ca2+](i) in the presence of caffeine and extracellular Ca2+ was attenuated in VSMCs from rats with advanced CKD. This impairment, together with reductions in expression of the Na+/Ca2+ exchanger, suggest a reduction in Ca2+ extrusion capability. Finally, store-operated Ca2+ entry (SOCE) was assessed following SR Ca2+ store depletion. Ca2+ entry during recovery from caffeine-induced SR Ca2+ store release was elevated in advanced CKD, suggesting a role for exacerbated SOCE with progressing CKD.
   Conclusions: With progressive CKD in the Cy/+ rat there is increased resting [Ca2+] i in VSMCs due, in part, to increased SOCE and impaired calcium extrusion from the cell. Such changes may predispose VSMCs to phenotypic changes that are a prerequisite to calcification.
C1 [Rodenbeck, Stacey Dineen; McKenney-Drake, Mikaela L.; Bruning, Rebecca S.; Sturek, Michael] Indiana Univ Sch Med, Dept Cellular & Integrat Physiol, Indianapolis, IN 46202 USA.
   [Zarse, Chad A.; Chen, Neal X.; Moe, Sharon M.] Indiana Univ Sch Med, Div Nephrol, Dept Med, 950 W Walnut St,R2-202, Indianapolis, IN 46202 USA.
   [Moe, Sharon M.] Indiana Univ Sch Med, Dept Anat & Cell Biol, Indianapolis, IN 46202 USA.
   [Moe, Sharon M.] Roudebush Vet Affairs Med Ctr, Dept Med, Indianapolis, IN 46202 USA.
C3 Indiana University System; Indiana University Bloomington; Indiana
   University System; Indiana University Bloomington; Indiana University
   System; Indiana University Bloomington; US Department of Veterans
   Affairs; Veterans Health Administration (VHA); Richard L. Roudebush VA
   Medical Center
RP Moe, SM (corresponding author), Indiana Univ Sch Med, Div Nephrol, Dept Med, 950 W Walnut St,R2-202, Indianapolis, IN 46202 USA.; Moe, SM (corresponding author), Indiana Univ Sch Med, Dept Anat & Cell Biol, Indianapolis, IN 46202 USA.; Moe, SM (corresponding author), Roudebush Vet Affairs Med Ctr, Dept Med, Indianapolis, IN 46202 USA.
EM smoe@iu.edu
RI Sturek, Michael/CAH-2948-2022
OI Bruning-Barry, Rebecca/0000-0003-1229-247X; Sturek,
   Michael/0000-0002-2920-7406
FU National Institutes of Health [R01-AR058005]; VA Merit Award; Sanofi
   Nephrology Fellowship; NIH Vascular Biology Training [T32 HL079995]
FX This study was supported by National Institutes of Health Grant
   R01-AR058005 (to S.M.M.), a VA Merit Award (to S.M.M.), a 2013-2014
   Sanofi Nephrology Fellowship award (to C.A.Z.) and an NIH T32 HL079995
   Vascular Biology Training grant (C.A.Z., R.S.B.). We thank Zhenhui Chen,
   MD for the gift of SERCA2a antibody and Shannon Roy and Kalisha O'Neill
   for measuring serum biochemistries. This was presented in poster form at
   the 2015 American Society of Nephrology annual meeting.
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NR 87
TC 21
Z9 23
U1 0
U2 7
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0931-0509
EI 1460-2385
J9 NEPHROL DIAL TRANSPL
JI Nephrol. Dial. Transplant.
PD MAR
PY 2017
VL 32
IS 3
BP 450
EP 458
DI 10.1093/ndt/gfw274
PG 9
WC Transplantation; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Transplantation; Urology & Nephrology
GA EQ5IZ
UT WOS:000398117600011
PM 27510531
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU De Maddalena, C
   Bellini, M
   Berra, M
   Meriggiola, MC
   Aloisi, AM
AF De Maddalena, Chiara
   Bellini, Martina
   Berra, Marta
   Meriggiola, Maria Cristina
   Aloisi, Anna Maria
TI Opioid-Induced Hypogonadism: Why and How to Treat It
SO PAIN PHYSICIAN
LA English
DT Review
DE Pain; pain therapy; hypogonadism; adverse effects; morphine; HRT;
   testosterone
ID MIDDLE-AGED MEN; LATE-ONSET HYPOGONADISM; SEXUAL DESIRE DISORDER;
   TESTOSTERONE UNDECANOATE; SERUM TESTOSTERONE; BIOAVAILABLE TESTOSTERONE;
   DEFICIENCY SYNDROMES; METABOLIC SYNDROME; NONMALIGNANT PAIN; MENOPAUSAL
   WOMEN
AB Background: Gonadal hormones are critical factors in modulating the experience of pain, as suggested by the several sex differences observed: women have a greater risk of many clinical pain conditions, and postoperative and procedural pain may be more severe in them than in men. A growing body of literature demonstrates the role of estrogen in the female pain experience, whereas less attention has been given to testosterone and its functions.
   Nevertheless, testosterone has an appreciable role in both women and men: adequate serum levels are required in males and females for libido and sexuality; cellular growth; maintenance of muscle mass and bone; healing; blood-brain barrier; and for central nervous system maintenance. Pain therapy, and particularly opioid therapy, has been shown to affect testosterone plasma levels. Thus, the chronic administration of pain killers, such as opioids, requires the physician to be aware of both the consequences that can develop due to long-term testosterone impairment and the available means to restore and maintain physiological testosterone levels.
   Objective: The objective is to highlight to pain physicians that the endocrine changes occurring during chronic pain therapy can participate in the body dysfunctions often present in chronic pain patients and that there are possible hormone replacement methods that can be carried out in men and women to improve their quality of life.
   Study Design: A comprehensive review of the literature.
   Methods: A comprehensive review of the literature relating to opioid-induced hypogonadism, as well as other very common forms of hypogonadism, its endocrine effects, and possible therapeutic actions. The literature was collected from electronic and other sources. The reviewed literature included observational studies, case reports, systematic reviews, and guidelines.
   Outcome Measures: Evaluation of the endocrine changes described in chronic pain therapy was the primary outcome measure. The secondary outcome measures were functional improvement and adverse effects of hormone replacement.
   Results: The results of the survey clearly show that sex hormone determination is very rare in pain centers. Given the complexity and widespread nature of pain therapy, there is a paucity of qualitative and quantitative literature regarding its endocrine consequences. The available evidence is weak for pain relief, but is consistent for many collateral effects, possibly deriving from pain therapy, such as fatigue, depression, and neurodegenerative diseases.
   Limitation: This is a narrative review without application of methodological quality assessment criteria. Even so, there is a paucity of literature concerning both controlled and observational literature for the endocrine effects of most analgesic drugs.
   Conclusion: Testosterone replacement suffers from old prejudices about its utility and safety. With this review we illustrate the available therapeutic choices able to maintain T concentration into physiological ranges and reduce nociception with a final goal of improving patients' quality of life.
C1 [De Maddalena, Chiara; Bellini, Martina; Berra, Marta; Meriggiola, Maria Cristina; Aloisi, Anna Maria] Univ Siena, I-53100 Siena, Italy.
C3 University of Siena
RP Aloisi, AM (corresponding author), Univ Siena, Dept Physiol, Neurophysiol Lab, Via Aldo Moro 2, I-53100 Siena, Italy.
EM annamaria.aloisi@unisi.it
RI Aloisi, Anna/AAV-7384-2021
FU Fondazione Emilio Bernardelli (Milano, Italy)
FX The authors thank the Fondazione Emilio Bernardelli (Milano, Italy) for
   funding this research.
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NR 57
TC 40
Z9 43
U1 0
U2 6
PU AM SOC INTERVENTIONAL PAIN PHYSICIANS
PI PADUCAH
PA 81 LAKEVIEW DR, PADUCAH, KY 42001 USA
SN 1533-3159
J9 PAIN PHYSICIAN
JI Pain Physician
PD JUL
PY 2012
VL 15
IS 3
SU S
SI SI
BP ES111
EP ES118
PG 8
WC Anesthesiology; Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Anesthesiology; Neurosciences & Neurology
GA 083KD
UT WOS:000314461300007
PM 22786450
DA 2025-06-11
ER

PT J
AU Zhong, X
   Ao, Q
   Xing, F
AF Zhong, Xiao
   Ao, Qin
   Xing, Fei
TI RETRACTED: Serum Levels of HCY, MIF, and hs-CRP Correlate with
   Glycolipid Metabolism in Adults with Never-Medicated First-Episode
   Schizophrenia (Retracted Article)
SO EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Article; Retracted Publication
ID BIPOLAR DISORDER; PREVALENCE; COMPONENTS; PROTEIN; DISEASE; TIME; RISK
AB Objective. It has been reported that the prevalence of metabolic syndrome (MS) in multiepisode patients with schizophrenia is 35.3%, which is 2- to 4-fold higher than in the general population. The study is designed to compare the glycolipid metabolism in patients with first-episode schizophrenia (FES) with sex- and age-matched healthy controls to investigate changes in serum levels of homocysteine (Hcy), macrophage migration inhibitory factor (MIF), and high-sensitive C-reactive protein (hs-CRP) and their relationships with the glycolipid metabolism in patients with FES. Methods. His case-control study included 88 patients diagnosed with FES and 88 sex- and age-matched healthy controls. Patient psychopathology was assessed using the Positive and Negative Syndrome Scale (PANSS), Young Mania Rating Scale (YMRS), and 17-item Hamilton Rating Scale for Depression (HAMD-17). Patients with FES were classified into MS and non-MS groups. Results.There were significant differences in the education level, body mass index (BMI), and waist circumference between the patients with FES and healthy controls (all p > 0.05). The patients with FES had higher levels of FPG and blood glucose at the oral glucose tolerance test (OGTT) (2 h glucose) concomitant with higher proportion of impaired glucose tolerance (IGT) and homeostasis model assessment of insulin resistance (HOMA2-IR) than healthy controls (all p < 0.001). It was revealed that the patients with FES showed higher serum levels of Hcy, MIF, and hs-CRP than healthy controls (all p < 0.001). The serum level of Hcy shared positive correlations with the score of PANSS totals (r = 0.551) and the negative syndrome of the PANSS scale (r = 0.494).The serum levels of MIF and hs-CRP was only positively correlated with the negative syndrome of the PANSS scale (r = 0.320 and r = 0.446). The level of Hcy shared positive correlations with the levels of FPG, 2 h glucose, and HOMA2-IR; the level of MIF was only positively correlated with the level of HOMA2-IR; the level of hs-CRP had a positive correlation with both levels of FPG and 2 h glucose (all p < 0.001). The levels of Hcy, MIF, and hs-CRP all shared positive correlations with the TG level and negative correlations with the HDLC level (all p < 0.001). There were remarkable differences between the MS and non-MS groups with regard to BMI, waist circumference, negative subscale of the PANSS scale, FPG, TG, and HDL-C (all p < 0.05). Elevated levels of Hcy, MIF, and hs-CRP were detected in the MS group compared to the non-MS group (all p < 0.05). Conclusion.These findings suggest that increased concentrations of HCY, MIF, and hs-CRP may contribute to the abnormal glycolipid metabolism in the context of schizophrenia.
C1 [Zhong, Xiao; Ao, Qin] Jiangxi Kangning Hosp, Jiangxi Prov Honorary Mil Rehabil Hosp, Psychiat Dept, Yuhushan Ave, Nanchang 330103, Jiangxi, Peoples R China.
   [Xing, Fei] Second Peoples Hosp Huaian, Dept Clin Lab, 62 Huaihai South Rd, Huaian City 223001, Jiangsu, Peoples R China.
RP Xing, F (corresponding author), Second Peoples Hosp Huaian, Dept Clin Lab, 62 Huaihai South Rd, Huaian City 223001, Jiangsu, Peoples R China.
EM xinghy2016@sina.com
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NR 37
TC 5
Z9 5
U1 0
U2 3
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1741-427X
EI 1741-4288
J9 EVID-BASED COMPL ALT
JI Evid.-based Complement Altern. Med.
PD NOV 13
PY 2021
VL 2021
AR 7394699
DI 10.1155/2021/7394699
PG 9
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Integrative & Complementary Medicine
GA ZQ0CP
UT WOS:000766782400003
PM 34812265
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Correll, CU
   Solmi, M
   Veronese, N
   Bortolato, B
   Rosson, S
   Santonastaso, P
   Thapa-Chhetri, N
   Fornaro, M
   Gallicchio, D
   Collantoni, E
   Pigato, G
   Favaro, A
   Monaco, F
   Kohler, C
   Vancampfort, D
   Ward, PB
   Gaughran, F
   Carvalho, AF
   Stubbs, B
AF Correll, Christoph U.
   Solmi, Marco
   Veronese, Nicola
   Bortolato, Beatrice
   Rosson, Stella
   Santonastaso, Paolo
   Thapa-Chhetri, Nita
   Fornaro, Michele
   Gallicchio, Davide
   Collantoni, Enrico
   Pigato, Giorgio
   Favaro, Angela
   Monaco, Francesco
   Kohler, Cristiano
   Vancampfort, Davy
   Ward, Philip B.
   Gaughran, Fiona
   Carvalho, Andre F.
   Stubbs, Brendon
TI Prevalence, incidence and mortality from cardiovascular disease in
   patients with pooled and specific severe mental illness: a large-scale
   meta-analysis of 3,211,768 patients and 113,383,368 controls
SO WORLD PSYCHIATRY
LA English
DT Article
DE Cardiovascular disease; severe mental illness; schizophrenia; bipolar
   disorder; major depression; coronary heart disease; cerebrovascular
   disease; congestive heart failure; premature mortality
ID CORONARY-HEART-DISEASE; SCHIZOPHRENIA SPECTRUM DISORDERS; ACUTE
   MYOCARDIAL-INFARCTION; GENERAL-MEDICAL CONDITIONS; MAJOR DEPRESSIVE
   DISORDER; BIPOLAR DISORDER; FOLLOW-UP; METABOLIC SYNDROME; RISK-FACTORS;
   PHYSICAL ILLNESS
AB People with severe mental illness (SMI) - schizophrenia, bipolar disorder and major depressive disorder - appear at risk for cardiovascular disease (CVD), but a comprehensive meta-analysis is lacking. We conducted a large-scale meta-analysis assessing the prevalence and incidence of CVD; coronary heart disease; stroke, transient ischemic attack or cerebrovascular disease; congestive heart failure; peripheral vascular disease; and CVD-related death in SMI patients (N=3,211,768) versus controls (N=113,383,368) (92 studies). The pooled CVD prevalence in SMI patients (mean age 50 years) was 9.9% (95% CI: 7.4-13.3). Adjusting for a median of seven confounders, patients had significantly higher odds of CVD versus controls in cross-sectional studies (odds ratio, OR=1.53, 95% CI: 1.27-1.83; 11 studies), and higher odds of coronary heart disease (OR=1.51, 95% CI: 1.47-1.55) and cerebrovascular disease (OR=1.42, 95% CI: 1.21-1.66). People with major depressive disorder were at increased risk for coronary heart disease, while those with schizophrenia were at increased risk for coronary heart disease, cerebrovascular disease and congestive heart failure. Cumulative CVD incidence in SMI patients was 3.6% (95% CI: 2.7-5.3) during a median follow-up of 8.4 years (range 1.8-30.0). Adjusting for a median of six confounders, SMI patients had significantly higher CVD incidence than controls in longitudinal studies (hazard ratio, HR=1.78, 95% CI: 1.60-1.98; 31 studies). The incidence was also higher for coronary heart disease (HR=1.54, 95% CI: 1.30-1.82), cerebrovascular disease (HR=1.64, 95% CI: 1.26-2.14), congestive heart failure (HR=2.10, 95% CI: 1.64-2.70), and CVD-related death (HR=1.85, 95% CI: 1.53-2.24). People with major depressive disorder, bipolar disorder and schizophrenia were all at increased risk of CVD-related death versus controls. CVD incidence increased with antipsychotic use (p=0.008), higher body mass index (p=0.008) and higher baseline CVD prevalence (p=0.03) in patients vs. controls. Moreover, CVD prevalence (p=0.007), but not CVD incidence (p=0.21), increased in more recently conducted studies. This large-scale meta-analysis confirms that SMI patients have significantly increased risk of CVD and CVD-related mortality, and that elevated body mass index, antipsychotic use, and CVD screening and management require urgent clinical attention.
C1 [Correll, Christoph U.] Northwell Hlth, Psychiat Res, Zucker Hillside Hosp, Glen Oaks, NY 11004 USA.
   [Correll, Christoph U.] Hofstra Northwell Sch Med, Dept Psychiat & Mol Med, Hempstead, NY 11549 USA.
   [Correll, Christoph U.] Feinstein Inst Med Res, Ctr Psychiat Neurosci, Manhasset, NY 11030 USA.
   [Correll, Christoph U.] Albert Einstein Coll Med, Dept Psychiat & Behav Med, Bronx, NY 10467 USA.
   [Correll, Christoph U.; Solmi, Marco; Veronese, Nicola; Bortolato, Beatrice; Monaco, Francesco; Carvalho, Andre F.; Stubbs, Brendon] Inst Clin Res & Educ Med, Padua, Italy.
   [Solmi, Marco; Rosson, Stella; Santonastaso, Paolo; Gallicchio, Davide; Collantoni, Enrico; Pigato, Giorgio; Favaro, Angela] Univ Padua, Dept Neurosci, Padua, Italy.
   [Solmi, Marco] Mental Hlth Dept, Local Hlth Unit 17, Padua, Italy.
   [Bortolato, Beatrice] Mental Hlth Dept, Local Hlth Unit 10, Portogruaro, Italy.
   [Thapa-Chhetri, Nita] Univ Connecticut, Ctr Hlth, Farmington, CT USA.
   [Fornaro, Michele] Columbia Univ, New York Psychiat Inst, New York, NY USA.
   [Kohler, Cristiano; Carvalho, Andre F.] Univ Fed Ceara, Dept Clin Med & Translat Psychiat Res Grp, Fortaleza, Ceara, Brazil.
   [Vancampfort, Davy] KU Leuven Dept Rehabil Sci, Leuven, Belgium.
   [Vancampfort, Davy] KU Leuven Univ Psychiat Ctr, Leuven Kortenberg, Belgium.
   [Ward, Philip B.] Univ New South Wales, Sch Psychiat, Sydney, NSW, Australia.
   [Gaughran, Fiona; Stubbs, Brendon] NHS Fdn Trust, South London & Maudsley, London, England.
   [Stubbs, Brendon] Kings Coll London, Hlth Serv & Populat Res Dept, Inst Psychiat Psychol & Neurosci, London, England.
   [Stubbs, Brendon] Kings Coll London, Dept Psychosis Studies, Inst Psychiat Psychol & Neurosci, London, England.
C3 Northwell Health; Northwell Health; Northwell Health; Yeshiva
   University; Montefiore Medical Center; Albert Einstein College of
   Medicine; University of Padua; University of Connecticut; Columbia
   University; New York State Psychiatry Institute; Universidade Federal do
   Ceara; KU Leuven; University of New South Wales Sydney; Oxford
   University Hospitals NHS Foundation Trust; University of London; King's
   College London; University of London; King's College London
RP Correll, CU (corresponding author), Northwell Hlth, Psychiat Res, Zucker Hillside Hosp, Glen Oaks, NY 11004 USA.; Correll, CU (corresponding author), Hofstra Northwell Sch Med, Dept Psychiat & Mol Med, Hempstead, NY 11549 USA.; Correll, CU (corresponding author), Feinstein Inst Med Res, Ctr Psychiat Neurosci, Manhasset, NY 11030 USA.; Correll, CU (corresponding author), Albert Einstein Coll Med, Dept Psychiat & Behav Med, Bronx, NY 10467 USA.; Correll, CU (corresponding author), Inst Clin Res & Educ Med, Padua, Italy.
RI Stubbs, Brendon/X-1904-2018; Veronese, Nicola/K-4343-2018; Vancampfort,
   Davy/AAD-1987-2019; Correll, Christoph/D-3530-2011; Carvalho,
   Andre/AEZ-4001-2022; Gaughran, Fiona/AAC-7160-2019; solmi,
   marco/K-3906-2018; Stubbs, Brendon/C-5696-2015; Ward,
   Philip/JCE-6293-2023; Favaro, Angela/J-2966-2012; Monaco,
   Francesco/ADD-7161-2022; Gaughran, Fiona/H-5495-2011
OI solmi, marco/0000-0003-4877-7233; Stubbs, Brendon/0000-0001-7387-3791;
   Ward, Philip/0000-0002-5779-7722; Favaro, Angela/0000-0002-6540-5194;
   collantoni, enrico/0000-0002-6730-1778; Monaco,
   Francesco/0000-0002-1854-292X; Rosson, Stella/0000-0002-8554-3519;
   Gaughran, Fiona/0000-0001-7414-5569
FU National Institute for Health Research (NIHR) Collaboration for
   Leadership in Applied Health Research and Care South London at King's
   College Hospital NHS Foundation Trust; National Institute for Health
   Research Collaboration for Leadership in Applied Health Research and
   Care Funding scheme; Stanley Medical Research Institute
FX B. Stubbs and F. Gaughran receive support from the National Institute
   for Health Research (NIHR) Collaboration for Leadership in Applied
   Health Research and Care South London at King's College Hospital NHS
   Foundation Trust. F. Gaughran is also funded by the National Institute
   for Health Research Collaboration for Leadership in Applied Health
   Research and Care Funding scheme and by the Stanley Medical Research
   Institute. The views expressed in this publication are those of the
   authors and not necessarily those of the funding institutions. C.U.
   Correll, M. Solmi and N. Veronese are joint first authors of the paper.
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NR 132
TC 1184
Z9 1234
U1 6
U2 135
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1723-8617
EI 2051-5545
J9 WORLD PSYCHIATRY
JI World Psychiatry
PD JUN
PY 2017
VL 16
IS 2
BP 163
EP 180
DI 10.1002/wps.20420
PG 18
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA EV3XI
UT WOS:000401692000017
PM 28498599
OA Green Submitted, Green Published, Bronze
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Ananloo, ES
   Ghaeli, P
   Kamkar, MZ
   Sadeghi, M
AF Ananloo, Esmaeil Shahsavand
   Ghaeli, Padideh
   Kamkar, Mohammad-Zaman
   Sadeghi, Majid
TI Comparing the effects of fluoxetine and imipramine on total cholesterol,
   triglyceride, and weight in patients with major depression
SO DARU-JOURNAL OF PHARMACEUTICAL SCIENCES
LA English
DT Article
DE Tricyclic antidepressants; Serotonin reuptake inhibitors; Cholesterol;
   Triglyceride; Body weight
ID SERUM-CHOLESTEROL; GAIN; DISORDER; ANTIDEPRESSANTS; COMORBIDITY
AB Background: There are some reports on the effects of antidepressants on metabolic syndrome. However, our search in the previously published literature showed a lack of information on the comparison of the effects of different classes of antidepressants on lipid profile. Therefore, this study was aimed to compare the effects of fluoxetine and imipramine on serum total cholesterol (TC) and triglyceride (TG) as well as body weight (BW) in patients with major depressive disorder.
   Methods: Fifty one patients, 18 to 70 years of age, with major depressive disorder complied with the criteria of this preliminary, open-label clinical trial. Subjects received either imipramine (75-200 mg/day) or fluoxetine (20-40 mg/day) for 8 weeks. Total cholesterol and TG levels, as well as BW were compared at baseline with those at weeks 4 and 8. Data was analyzed by SPSS software version 16.0.
   Results: In the fluoxetine group, TC levels decreased from 165.71 mg/dL to 156.71 mg/dL at week 4 (P = 0.07), and to 143.94 mg/dL at week 8 (P = 0.16); TG levels decreased from 129.35 mg/dL to 115.88 mg/dL at week 4 (P < 0.001), and to 110.41 mg/dL at week 8 (P = 0.56). In the imipramine group, TC levels increased from 169.10 mg/dL to 178.69 mg/dL at week 4 (P = 0.07), and to 208.69 mg/dL at week 8 (P < 0.001) while TG levels increased from 111.73 mg/dL to 128.83 mg/dL at week 4 (P = 0.005), and to 160.90 mg/dL at week 8 (P < 0.001). BW was significantly increased in the imipramine group at weeks 4 and 8. In the fluoxetine group, BW was non-significantly decreased from 75.69 +/- 7.97 Kg (baseline) to 75.67 +/- 8.01 Kg at week 4 (P = 0.88), and to 75.22 +/- 8.67 Kg at week 8 (P = 0.20), while in the imipramine group, BW had significant increases from 72.53 +/- 8.55 Kg (baseline) to 73.95 +/- 8.61 mg/dL at week 4 (P < 0.001), and to 75.13 +/- 8.34 mg/dL at week 8 (P < 0.001). Repeated measures ANOVA showed significant effects on both TC and TG levels as well as on BW in all patients receiving imipramine. However, in patients on fluoxetine, repeated measures ANOVA showed significant effects of this medication only on TC levels in males.
   Conclusions: Monitoring TC and TG and BW is recommended before starting imipramine in depressed patients with increased risk for cardiovascular disease. Fluoxetine may be the preferred agent in those with high or borderline high lipid levels.
C1 [Ananloo, Esmaeil Shahsavand] Tehran Univ Med Sci, Roozbeh Hosp, DGP, Tehran, Iran.
   [Ghaeli, Padideh] Tehran Univ Med Sci, Roozbeh Hosp, Tehran, Iran.
   [Kamkar, Mohammad-Zaman] Golestan Univ Med Sci, Azar Hosp 5, Gorgan, Iran.
   [Sadeghi, Majid] Tehran Univ Med Sci, Roozbeh Hosp, Psychiat & Psychol Res Ctr, Tehran, Iran.
C3 Tehran University of Medical Sciences; Roozbeh Hospital; Tehran
   University of Medical Sciences; Roozbeh Hospital; Golestan University of
   Medical Sciences; Tehran University of Medical Sciences; Roozbeh
   Hospital
RP Ghaeli, P (corresponding author), Tehran Univ Med Sci, Roozbeh Hosp, Tehran, Iran.
EM mmppg@yahoo.com
RI kamkar, mohammad zaman/S-8140-2016
OI kamkar, mohammad zaman/0000-0002-4613-7745
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NR 24
TC 16
Z9 16
U1 0
U2 13
PU SPRINGER INTERNATIONAL PUBLISHING AG
PI CHAM
PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND
SN 2008-2231
J9 DARU
JI DARU
PD JAN 5
PY 2013
VL 21
AR 4
DI 10.1186/2008-2231-21-4
PG 7
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 100PB
UT WOS:000315712100002
PM 23351476
OA Green Published
DA 2025-06-11
ER

PT J
AU Ibeneme, SC
   Mah, J
   Omeje, C
   Fortwengel, G
   Nwosu, AO
   Irem, FO
   Ibeneme, GC
   Myezwa, H
   Nweke, M
AF Ibeneme, Sam Chidi
   Mah, Juliet
   Omeje, Chidimma
   Fortwengel, Gerhard
   Nwosu, Akachukwu Omumuagwula
   Irem, Frank Onyemaechi
   Ibeneme, Georgian Chiaka
   Myezwa, Hellen
   Nweke, Martins
TI Effectiveness of pedometer-based walking programmes in improving some
   modifiable risk factors of stroke among community-dwelling older adults:
   a systematic review, theoretical synthesis and meta-analysis
SO BMC GERIATRICS
LA English
DT Review
DE Community-dwelling older adults; Stroke prevention; Modifiable risk
   factors; Pedometer-based walking
ID INCREASE PHYSICAL-ACTIVITY; SOCIAL COGNITIVE THEORY; POSTSTROKE
   DEPRESSION; ACTIVITY INTERVENTION; CLINICAL-TRIALS; BLOOD-PRESSURE;
   GLOBAL BURDEN; HEALTH; DISEASE; QUALITY
AB Background Pedometer-based walking programs hold promise as a health promotion strategy for stroke prevention in community-dwelling older adults, particularly when targeted at physical activity-related modifiable risk factors. The question arises: What is the effectiveness of pedometer-based walking program interventions in improving modifiable stroke risk factors among community-dwelling older adults? Method Eight databases were searched up to December 2nd, 2023, following the Preferred Reporting Items for Systematic Review and Meta-Analysis protocol. Inclusion criteria focused on randomized controlled trials (RCTS) involving community-dwelling older adults and reported in English. Two independent reviewers utilized Physiotherapy Evidence Database (PEDro) tool to extract data, assess eligibility, evaluate study quality, and identify potential bias. Standardized mean difference (SMD) was employed as summary statistics for primary -physical activity level -and secondary outcomes related to cardiovascular function (blood pressure) and metabolic syndrome, including obesity (measured by body mass index and waist circumference), fasting blood sugar, glycated hemoglobin, high-density lipoprotein cholesterol (HDL-C), and triglycerides. A random-effects model was used to generate summary estimates of effects. Results The review analyzed eight studies involving 1546 participants aged 60-85 years, with 1348 successfully completing the studies. Across these studies, pedometer-based walking programs were implemented 2-3 times per week, with sessions lasting 40-60 minutes, over a duration of 4-26 weeks. The risk of bias varied from high to moderate. Our narrative synthesis revealed positive trends in HDL-C levels, fasting blood sugar, and glycated hemoglobin, suggesting improved glycemic control and long-term blood sugar management. However, the impact on triglycerides was only marginal. Primary meta-analysis demonstrated significantly improved physical activity behavior (SMD=0.44,95%CI:0.26, 0.61,p=<0.00001;I-2=0%;4 studies; 532 participants) and systolic blood pressure (SMD=-0.34,95%CI:-0.59,-0.09;p=<0.008;I-2=65%,2 studies;249 participants), unlike diastolic blood pressure (SMD=0.13,95%CI:-0.13,-0.38,p=0.33; I-2=91%; 2 studies; 237 participants). Interventions based on social cognitive, self-efficacy, and self-efficiency theory(ies), and social cognitive theory applied in an ecological framework, were linked to successful physical activity behavior outcomes. Conclusion Pedometer-based walking programs, utilizing interpersonal health behavior theory/ecological framework, enhance physical activity behavior and have antihypertensive effects in community-dwelling older adults. While they do not significantly affect diastolic blood pressure, these programs potentially serve as a primary stroke prevention strategy aligning with global health goals.
C1 [Ibeneme, Sam Chidi; Mah, Juliet; Omeje, Chidimma; Nwosu, Akachukwu Omumuagwula; Irem, Frank Onyemaechi] Univ Nigeria, Coll Med, Fac Hlth Sci, Dept Med Rehabil, Enugu Campus, Enugu, Enugu State, Nigeria.
   [Fortwengel, Gerhard] Hsch Hannover Univ Appl Sci & Arts, Fac 3, D-30159 Hannover, Lower Saxony, Germany.
   [Mah, Juliet] Univ Nigeria, Teaching Hosp, Dept Physiotherapy, Enugu, Enugu State, Nigeria.
   [Ibeneme, Georgian Chiaka] Ebonyi State Univ, Coll Med, Fac Hlth Sci & Technol, Dept Nursing Sci, Abakaliki, Ebonyi State, Nigeria.
   [Ibeneme, Sam Chidi; Myezwa, Hellen] Univ Witwatersrand, Fac Hlth Sci, Dept Physiotherapy, Sch Therapeut Studies, 7 York Rd, ZA-2193 Johannesburg, Gauteng, South Africa.
   [Ibeneme, Sam Chidi; Nweke, Martins] David Umahi Fed Univ Hlth Sci, Fac Hlth Sci & Technol, Dept Physiotherapy, Uburu, Ebonyi State, Nigeria.
   [Ibeneme, Sam Chidi; Nweke, Martins] Univ Pretoria, Fac Hlth Sci, Dept Physiotherapy, Pretoria, South Africa.
   [Ibeneme, Georgian Chiaka] David Umahi Fed Univ Hlth Sci, Fac Hlth Sci & Technol, Dept Nursing Sci, Uburu, Ebonyi State, Nigeria.
C3 University of Nigeria; Hochschule Hannover-University of Applied
   Sciences & Arts; University of Nigeria; University of Witwatersrand;
   University of Pretoria
RP Ibeneme, SC (corresponding author), Univ Nigeria, Coll Med, Fac Hlth Sci, Dept Med Rehabil, Enugu Campus, Enugu, Enugu State, Nigeria.; Ibeneme, SC (corresponding author), Univ Witwatersrand, Fac Hlth Sci, Dept Physiotherapy, Sch Therapeut Studies, 7 York Rd, ZA-2193 Johannesburg, Gauteng, South Africa.; Ibeneme, SC (corresponding author), David Umahi Fed Univ Hlth Sci, Fac Hlth Sci & Technol, Dept Physiotherapy, Uburu, Ebonyi State, Nigeria.; Ibeneme, SC (corresponding author), Univ Pretoria, Fac Hlth Sci, Dept Physiotherapy, Pretoria, South Africa.
EM sam.ibeneme@unn.edu.ng
RI Nweke, Martins/AFU-8955-2022; Ibeneme, Sam/AAU-6547-2021; Myezwa,
   Hellen/AAH-1380-2021; Fortwengel, Gerhard/KWV-0671-2024
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NR 134
TC 0
Z9 0
U1 5
U2 9
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2318
J9 BMC GERIATR
JI BMC Geriatr.
PD JUN 13
PY 2024
VL 24
IS 1
AR 516
DI 10.1186/s12877-024-05069-z
PG 41
WC Geriatrics & Gerontology; Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA UP1F8
UT WOS:001249162200002
PM 38872081
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Kopetz, VA
   Penno, MAS
   Hoffmann, P
   Wilson, DP
   Beltrame, JF
AF Kopetz, Victoria A.
   Penno, Megan A. S.
   Hoffmann, Peter
   Wilson, David P.
   Beltrame, John F.
TI Potential mechanisms of the acute coronary syndrome presentation in
   patients with the coronary slow flow phenomenon - Insight from a plasma
   proteomic approach
SO INTERNATIONAL JOURNAL OF CARDIOLOGY
LA English
DT Article
DE Syndrome X; Coronary slow flow; Proteomics; 2-D DIGE
ID C-REACTIVE PROTEIN; PARAOXONASE-1 ACTIVITY; GEL-ELECTROPHORESIS;
   ALPHA-1-ANTITRYPSIN; FIBRONECTIN; ASSOCIATION; INFARCTION; DISEASE;
   ANGINA; LEVEL
AB Aims: The coronary slow flow phenomenon [CSFP] is a coronary microvascular disorder, characterized by delayed distal vessel opacification despite the absence of obstructive coronary artery disease. Patients frequently present with an acute coronary syndrome [ACS] although the pathophysiological mechanisms responsible are unknown. The aim of this study was to identify potential mechanisms for the ACS presentation associated with the CSFP using a plasma proteomic profiling approach.
   Methods and results: Plasma samples from nine CSFP subjects [56 +/- 11 years] were assayed for high sensitivity C-reactive protein [hsCRP], troponin T [TnT], creatine kinase [CK], and proteomic analyses (n=6), during an ACS presentation and one month later [chronic phase]. Proteomic analysis involved chromatographic depletion of abundant plasma proteins followed by two-dimensional differential gel electrophoresis [2-D DIGE]. Protein spots demonstrating +/- 1.5-fold change relative to the control were identified by mass spectrometry and two differentially expressed proteins were selected for validation via Western blotting. During the ACS presentation, hsCRP was elevated [ACS=14.9 +/- 3.9 mg/L vs chronic=4.23 +/- 1.37 mg/L, p=0.05] but TnT and CK levels were unchanged. Proteomic analysis identified six proteins that were significantly different in abundance between the acute and chronic samples. During the ACS presentation there was a 1.6 +/- 0.13 fold increase in the anti-oxidant enzyme paraoxonase-1 and an increase in inflammatory proteins alpha-1-antichymotrypsin [1.65 +/- 0.13 fold] and alpha-1-antitrypsin [2.5 +/- 0.34 fold]. The latter was confirmed by Western blotting [1.33 +/- 0.17 OD acute/chronic ratio, p=0.05].
   Conclusion: The findings from this novel detailed approach, implicate an inflammatory/oxidative stress process in the pathogenesis of the ACS presentation associated with the CSFP. Future studies should further elucidate these mechanisms. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
C1 [Kopetz, Victoria A.; Beltrame, John F.] Univ Adelaide, Queen Elizabeth Hosp, Discipline Med, Cardiol Unit, Woodville, SA 5011, Australia.
   [Penno, Megan A. S.; Hoffmann, Peter] Univ Adelaide, Adelaide Prote Ctr, Sch Mol & Biomed Sci, Woodville, SA 5011, Australia.
   [Wilson, David P.] Univ Adelaide, Discipline Physiol, Mol Physiol Vasc Funct Lab, Woodville, SA 5011, Australia.
C3 University of Adelaide; University of Adelaide; University of Adelaide
RP Beltrame, JF (corresponding author), Univ Adelaide, Queen Elizabeth Hosp, Discipline Med, Cardiol Unit, 28 Woodville Rd, Woodville, SA 5011, Australia.
EM john.beltrame@adelaide.edu.au
RI Beltrame, John/C-1687-2017; Penno, Megan/E-9626-2011; Hoffmann,
   Peter/U-5996-2017
OI Penno, Megan/0000-0002-9617-0826; Hoffmann, Peter/0000-0001-8493-2208
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NR 33
TC 32
Z9 42
U1 1
U2 29
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0167-5273
EI 1874-1754
J9 INT J CARDIOL
JI Int. J. Cardiol.
PD APR 5
PY 2012
VL 156
IS 1
BP 84
EP 91
DI 10.1016/j.ijcard.2011.09.014
PG 8
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 903QH
UT WOS:000301132900027
PM 21963214
DA 2025-06-11
ER

PT J
AU Brainin, P
   Frestad, D
   Prescott, E
AF Brainin, Philip
   Frestad, Daria
   Prescott, Eva
TI The prognostic value of coronary endothelial and microvascular
   dysfunction in subjects with normal or non-obstructive coronary artery
   disease: A systematic review and meta-analysis
SO INTERNATIONAL JOURNAL OF CARDIOLOGY
LA English
DT Review
DE Coronary vascular dysfunction; Epicardial endothelial dependent
   dysfunction; Non-endothelial dependent dysfunction; Coronary flow
   reserve; Coronary flow velocity reserve; Coronary heart disease
ID MYOCARDIAL BLOOD-FLOW; POSITRON-EMISSION-TOMOGRAPHY; DIPYRIDAMOLE STRESS
   ECHOCARDIOGRAPHY; ADVERSE CARDIOVASCULAR OUTCOMES; ANTERIOR DESCENDING
   ARTERY; VELOCITY RESERVE; VASCULAR DYSFUNCTION; NATIONAL-HEART;
   CHEST-PAIN; SYNDROME-X
AB Aims: Coronary vascular dysfunction is linked with poor cardiovascular prognosis in patients without obstructive coronary artery disease (CAD) but a critical appraisal of the literature is lacking.
   Methods and results: We performed a systematic review and meta-analysis to quantify the cardiovascular risk associated with endothelial dependent and non-endothelial dependent coronary vascular dysfunction in patients with normal or non-obstructive CAD (epicardial stenosis <50%). Prospective cohort studies that reported coronary vascular dysfunction at baseline and cardiovascular outcomes at follow-up were included. We identified 52 papers of which 26 were included in the meta-analyses. Study populations included stable angina (n = 15), heart failure (n = 4), diabetes (n = 2), hypertrophic obstructive cardiomyopathy (n = 2), chronic kidney disease, aortic stenosis and left atrial enlargement (each n = 1): RR estimates were similar in patients with stable angina and other patient groups. For epicardial endothelial dependent dysfunction (six studies, 243 events in 1192 patients) the summarized RR was 2.38 (95% confidence intervals (95% CI) 1.74-3.25), for non-endothelial dependent dysfunction assessed as coronary flow velocity reserve (CFVR) by echocardiography (10 studies, 428 events in 5134 patients) RR was 4.58 (95% CI 3.58-5.87) and for coronary flow reserve (CFR) by PET (10 studies, 538 events in 3687 patients) RR was 2.44 (95% CI 1.80-3.30). However, RR estimates were robust in a series of sensitivity analyses.
   Conclusion: The presence of coronary vascular dysfunction in patients with normal or non-obstructive CAD predicts adverse cardiovascular outcome. Multicentre studies and uniform guidelines for assessing coronary vascular dysfunction are encouraged. (c) 2017 Elsevier B.V. All rights reserved.
C1 [Brainin, Philip; Frestad, Daria; Prescott, Eva] Bispebjerg Hosp, Dept Cardiol, Bispebjerg Bakke 23, DK-2400 Copenhagen NV, Denmark.
   [Frestad, Daria] Hvidovre Univ Hosp, Dept Cardiol, Copenhagen, Denmark.
C3 University of Copenhagen; Copenhagen University Hospital; Bispebjerg
   Hospital; University of Copenhagen
RP Prescott, E (corresponding author), Bispebjerg Hosp, Dept Cardiol, Bispebjerg Bakke 23, DK-2400 Copenhagen NV, Denmark.
EM epre0004@regionh.dk
RI Prescott, Eva/AAJ-7441-2020
OI Prescott, Eva/0000-0002-4134-0349; Brainin, Philip/0000-0001-6880-0424;
   Bechsgaard, Daria Frestad/0000-0003-1767-4848
FU Danish Heart Association; Arvid Nilssons Foundation
FX Daria Frestad was funded by the Danish Heart Association and Arvid
   Nilssons Foundation.
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NR 94
TC 107
Z9 115
U1 2
U2 20
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0167-5273
EI 1874-1754
J9 INT J CARDIOL
JI Int. J. Cardiol.
PD MAR 1
PY 2018
VL 254
BP 1
EP 9
DI 10.1016/j.ijcard.2017.10.052
PG 9
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA FV4AB
UT WOS:000424514800001
PM 29407076
DA 2025-06-11
ER

PT J
AU Çamsari, A
   Pekdemir, H
   Çiçek, D
   Polat, G
   Akkus, MN
   Döven, O
   Cin, G
   Katircibasi, T
   Parmaksiz, T
AF Çamsari, A
   Pekdemir, H
   Çiçek, D
   Polat, G
   Akkus, MN
   Döven, O
   Cin, G
   Katircibasi, T
   Parmaksiz, T
TI Endothelin-1 and nitric oxide concentrations and their response to
   exercise in patients with slow coronary flow
SO CIRCULATION JOURNAL
LA English
DT Article
DE endothelin-1; nitric oxide; slow coronary flow
ID INTRAVASCULAR ULTRASOUND; SYNDROME-X; ANGINA-PECTORIS; EARLY
   ATHEROSCLEROSIS; PLASMA ENDOTHELIN; ARTERY FLOW; FRAME COUNT; HUMANS;
   HEART; ARTERIOGRAMS
AB In this study, the endothelin-1 (ET-1) and nitric oxide (NO) concentrations in slow coronary flow (SCF) patients were assessed before and at the peak of the exercise stress test and compared with the values from healthy controls. The study population was 25 patients who underwent coronary angiography and were diagnosed as SCF (I I females (44%), aged 56.7 +/- 9.8 years), and 20 normal subjects (9 females (45%), aged 54.3 +/- 9.2 years). Mean TIMI frame count in the patients was 54.1 +/- 13.4. Blood samples were drawn at rest and immediately at the end of exercise testing. The baseline ET-1 concentrations of the control subjects were lower than those of the patients (7.0 +/- 4.5 pg/ml vs 11.1 +/- 5.9 pg/ml p<0.0001) and this difference increased after exercise (6.2 +/- 4.3 pg/ml vs 20.1 +/- 10.4 pg/ml, p<0.0001). Post-exercise ET-1 concentrations were significantly higher than baseline in patients with SCF (p<0.0001) and a reduction in the ET-1 concentrations was observed in control subjects (p<0.05). Baseline NO concentrations of the patients were lower than those of the control subjects (27 +/- 5.1 mumol/L vs 31.2 +/- 4.9 mumol/L, p=0.0001). Although the NO concentrations in both groups were significantly increased after exercise (29.4 +/- 5.9 mumol/L vs 33.3 +/- 5.6 mumol/L, p<0.05 for both), the difference was not significant. A significant negative correlation among post-exercise ET-1 concentrations and maximal heart rate, exercise duration and exercise rate-pressure product, and a significant positive correlation among post-exercise NO concentrations and maximal heart rate and exercise duration were observed in both groups. The results of this study show that endothelial function (assessed by ET-I and NO concentrations) and its response to exercise were abnormal in SCF patients compared with healthy subjects, and this may play some pathophysiologic role.
C1 Mersin Univ, Fac Med, Dept Cardiol, TR-33070 Mersin, Turkey.
   Mersin Univ, Fac Med, Dept Biochem, TR-33070 Mersin, Turkey.
C3 Mersin University; Mersin University
RP Çamsari, A (corresponding author), Mersin Univ, Tip Fak, Kardiyol Ogretim Uyesi, TR-33070 Mersin, Turkey.
EM ahmetcamsari@hotmail.com
RI Pekdemir, Hasan/ABI-6096-2020; Camsari, Ahmet/F-4540-2015
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NR 40
TC 94
Z9 105
U1 0
U2 15
PU JAPANESE CIRCULATION SOC
PI KYOTO
PA KINKI INVENTION CENTER, 14 YOSHIDA KAWAHARACHO, SAKYO-KU, KYOTO,
   606-8305, JAPAN
SN 1346-9843
J9 CIRC J
JI Circ. J.
PD DEC
PY 2003
VL 67
IS 12
BP 1022
EP 1028
DI 10.1253/circj.67.1022
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 749PA
UT WOS:000186928100009
PM 14639018
OA Bronze
DA 2025-06-11
ER

PT J
AU Gavrieli, A
   Farr, OM
   Davis, CR
   Crowell, JA
   Mantzoros, CS
AF Gavrieli, Anna
   Farr, Olivia M.
   Davis, Cynthia R.
   Crowell, Judith A.
   Mantzoros, Christos S.
TI Early life adversity and/or posttraumatic stress disorder severity are
   associated with poor diet quality, including consumption of trans fatty
   acids, and fewer hours of resting or sleeping in a US middle-aged
   population: A cross-sectional and prospective study
SO METABOLISM-CLINICAL AND EXPERIMENTAL
LA English
DT Article
DE PTSD; Early life adversity; Diet quality; Physical activity; Resting and
   sleeping
ID CORONARY-HEART-DISEASE; CIGARETTE-SMOKING; CHILDHOOD EXPERIENCES;
   INSUFFICIENT SLEEP; METABOLIC SYNDROME; SODA CONSUMPTION; PHYSICAL
   HEALTH; TRAUMA EXPOSURE; RISK-FACTORS; OBESITY
AB Background. Early life adversity (ELA) and post-traumatic stress disorder (PTSD) are associated with poorer psychological and physical health. Potential underlying mechanisms and mediators remain to be elucidated, and the lifestyle habits and characteristics of individuals with ELA and/or PTSD have not been fully explored. We investigated whether the presence of ELA and/or PTSD are associated with nutrition, physical activity, resting and sleeping and smoking.
   Methods. A cross-sectional sample of 151 males and females (age: 45.6 +/- 3.5 years, BMI: 30.0 +/- 7.1 kg/m(2)) underwent anthropometric measurements, as well as detailed questionnaires for dietary assessment, physical activity, resting and sleeping, smoking habits and psychosocial assessments. A prospective follow-up visit of 49 individuals was performed 2.5 years later and the same outcomes were assessed. ELA and PTSD were evaluated as predictors, in addition to a variable assessing the combined presence/severity of ELA PTSD. Data were analyzed using analysis of covariance after adjusting for several socioeconomic, psychosocial and anthropometric characteristics.
   Results. Individuals with higher ELA or PTSD severity were found to have a poorer diet quality (DASH score: p = 0.006 and p = 0.003, respectively; aHEI-2010 score: ELA p = 0.009), including further consumption of trans fatty acids (ELA p = 0.003); the differences were significantly attenuated null after adjusting mainly for education or income and/or race. Further, individuals with higher ELA severity reported less hours of resting and sleeping (p = 0.043) compared to those with zero/lower ELA severity, and the difference remained significant in the fully adjusted model indicating independence from potential confounders. When ELA and PTSD were combined, an additive effect was observed on resting and sleeping (p = 0.001); results remained significant in the fully adjusted model. They also consumed more energy from trans fatty acids (p = 0.017) tended to smoke more (p = 0.008), and have less physical activity (PTSD p = 0.024) compared to those with no or lower ELA and PTSD severity. Adjustments for sociodemographic factors and/or BMI rendered results of the above lifestyle parameters non-significant. The analysis of the prospective data showed similar trends to the cross-sectional analysis, further supporting the conclusions, although statistical significance of results was lower due to the lower number of participants.
   Conclusion. Fewer hours of resting and sleeping and poorer diet quality are linked to ELA and/or PTSD, indicating that these pathways might underlie the development of several metabolic abnormalities in individuals with ELA and/or PTSD. Differences in terms of diet quality are significantly attenuated by race and/or education and/or income, whereas differences in other lifestyle habits of individuals with and without ELA and/or PTSD, such as physical activity, are mostly explained by confounding sociodemographic variables and/or body mass index. (C) 2015 Elsevier Inc. All rights reserved.
C1 [Gavrieli, Anna; Farr, Olivia M.; Mantzoros, Christos S.] Harvard Univ, Sch Med, Boston VA Healthcare Syst, Endocrinol Sect, Jamaica Plain, MA 02130 USA.
   [Gavrieli, Anna; Farr, Olivia M.; Mantzoros, Christos S.] Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Dept Internal Med, Boston, MA 02215 USA.
   [Davis, Cynthia R.; Crowell, Judith A.] Judge Baker Childrens Ctr, Boston, MA 02120 USA.
   [Crowell, Judith A.] SUNY Stony Brook, Dept Psychiat, Sch Med, Stony Brook, NY 11794 USA.
C3 Harvard University; Harvard University; Harvard University Medical
   Affiliates; Beth Israel Deaconess Medical Center; Harvard Medical
   School; Harvard University; Harvard University Medical Affiliates; Judge
   Baker's Children's Center; State University of New York (SUNY) System;
   Stony Brook University
RP Farr, OM (corresponding author), Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Dept Internal Med, 330 Brookline Ave, Boston, MA 02215 USA.
EM ofarr@bidmc.harvard.edu
RI Farr, Olivia/H-6929-2019; Mantzoros, Christos/Y-2902-2019
OI Farr, Olivia/0000-0002-5182-3432
FU National Institute of Aging [RO1-AG032030]; National Institute of
   Diabetes and Digestive and Kidney Diseases [DK81913]; Clinical Science
   Research and Development Service of the VA Office of Research and
   Development [1I01CX000422-01A1]; National Center for Research Resources
   [UL1 RR025758]; NICHD [5T32HD052961]
FX This study was supported by the National Institute of Aging Grant
   RO1-AG032030 and National Institute of Diabetes and Digestive and Kidney
   Diseases Grant DK81913 and Award 1I01CX000422-01A1 from the Clinical
   Science Research and Development Service of the VA Office of Research
   and Development. The project was also supported by Harvard Clinical and
   Translational Science Center Grant UL1 RR025758 from the National Center
   for Research Resources. Olivia M. Farr is supported by a training grant
   through the NICHD 5T32HD052961.
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NR 74
TC 38
Z9 40
U1 0
U2 32
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0026-0495
EI 1532-8600
J9 METABOLISM
JI Metab.-Clin. Exp.
PD NOV
PY 2015
VL 64
IS 11
BP 1597
EP 1610
DI 10.1016/j.metabol.2015.08.017
PG 14
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism
GA CU3PJ
UT WOS:000363437000027
PM 26404481
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Chai, JT
   Wang, YT
   Sun, ZY
   Zhou, Q
   Xu, JC
AF Chai, Jiatong
   Wang, Yiting
   Sun, Zeyu
   Zhou, Qi
   Xu, Jiancheng
TI Evaluation among trace elements, clinical parameters and type 1 diabetes
   according to sex: A new sight of auxiliary prediction in negative
   insulin auto-antibodies population
SO JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
LA English
DT Article
DE Type 1 diabetes; Trace elements; Sex; Prediction model; Clinical
   parameters
ID BETA-CELL FUNCTION; OXIDATIVE STRESS; METABOLIC SYNDROME; DIETARY
   MAGNESIUM; GLYCEMIC CONTROL; ZINC; CHILDREN; MELLITUS; RISK; IRON
AB Background: Type 1 diabetes (T1D) exhibited sex-specific metabolic status including oxidative stress with dy-namic change of trace elements, which emphasized the importance of the evaluation of trace elements according to sex. Besides, the most significant characteristic, insulin auto-antibodies, could not be found in all T1D patients, which needed the auxiliary prediction of clinical parameters. And it would benefit the early detection and treatment if some high-risk groups of T1D could predict and prevent the occurrence of disease through common clinical parameters. Hence, there was an urgent need to construct more effective and scientific statistical pre-diction models to serve clinic better. This study aimed to evaluate the sex-specific levels of trace elements and the relationship between trace elements and clinical parameters in T1D, and construct sex-specific auxiliary pre-diction model combined with trace elements and clinical parameters. Methods: A total of 105 T1D patients with negative insulin auto-antibodies and 105 age/sex-matched healthy individuals were enrolled in First Hospital of Jilin University. Inductively Coupled Plasma Mass Spectrometry was performed for the measurement of calcium (Ca), magnesium (Mg), zinc (Zn), copper (Cu), iron (Fe), sele-nium (Se) in the serum, and the data of clinical parameters were received from medical record system. The lambda-mu-sigma method was used to evaluate the relationship between abnormal clinical parameters and trace elements. Training set and validation set were divided for the construction of predictable models in males and females: clinical parameters model, trace element model and the combined model (clinical parameters and trace elements). Goodness fit test, decision curve analysis and other related statistical methods were used to perform data analysis. Results: Lower levels of Mg, Ca, Fe in the serum were found in T1D population in females compared with healthy population, while levels of Fe, Zn and Cu of serum in T1D individuals were higher than those of healthy pop-ulation in males. Levels of serum Mg, Fe and Cu in T1D group were found with significant sex difference for (P < 0.05), and the levels of Fe and Cu in serum of males were higher than those of females, level of serum Mg in males was lower than those of females. Levels of serum Mg and Zn showed fluctuation trend with increased numbers of abnormal clinical parameters (NACP) in males. Serum Zn in females showed consistent elevated trend with NACP; serum Se increased first and then decreased with NACP in males and females. The auxiliary prediction model (Triglyceride, Total protein, serum Mg) was found with the highest predicted efficiency in males (AUC=0.993), while the model in females (Apolipoprotein A, Creatinine, Fe, Se, Zn/Cu ratio) showed the best predicted efficiency (AUC=0.951). The models had passed the verification in validation set, and Chi-square goodness-of-fit test, DCA results both confirmed their satisfactory clinical applicability. Conclusion: Sex-specific difference were found in serum Mg, Fe and Cu in T1D. The combination of triglyceride, total protein and serum Mg for males, and apolipoprotein A, creatinine, Fe, Se, Zn/Cu ratio for females could effectively predict T1D in patients with negative anti-bodies, which would provide alarm for the population with high-risk of T1D and serve the T1D prediction in patients with negative anti-bodies.
C1 [Chai, Jiatong; Wang, Yiting; Sun, Zeyu; Zhou, Qi; Xu, Jiancheng] Jilin Univ, Hosp 1, Dept Lab Med, Changchun, Peoples R China.
C3 Jilin University
RP Xu, JC (corresponding author), Jilin Univ, Hosp 1, Dept Lab Med, Changchun, Peoples R China.
EM xjc@jlu.edu.cn
RI Wang, Yiting/S-2558-2017
FU Jilin Science and Technology Development Program;  [20190304110YY]; 
   [20200404171YY]
FX Funding Statement This work was supported by grants from the Jilin
   Science and Technology Development Program (no. 20190304110YY to Dr.
   Jian-cheng Xu; no. 20200404171YY to Dr. Qi Zhou) .
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NR 82
TC 4
Z9 4
U1 0
U2 4
PU ELSEVIER GMBH
PI MUNICH
PA HACKERBRUCKE 6, 80335 MUNICH, GERMANY
SN 0946-672X
EI 1878-3252
J9 J TRACE ELEM MED BIO
JI J. Trace Elem. Med. Biol.
PD JAN
PY 2023
VL 75
AR 127100
DI 10.1016/j.jtemb.2022.127100
EA NOV 2022
PG 18
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 7S6JJ
UT WOS:000910858400003
PM 36410305
OA hybrid
DA 2025-06-11
ER

PT J
AU de la Monte, SM
AF de la Monte, Suzanne M.
TI Contributions of Brain Insulin Resistance and Deficiency in
   Amyloid-Related Neurodegeneration in Alzheimer's Disease
SO DRUGS
LA English
DT Review
ID MILD COGNITIVE IMPAIRMENT; CEREBROSPINAL-FLUID BIOMARKERS; GROWTH-FACTOR
   EXPRESSION; GLUCAGON-LIKE PEPTIDE-1; CEREBRAL GLUCOSE-METABOLISM;
   ACTIVATED PROTEIN-KINASE; FACTOR BINDING-PROTEINS;
   CENTRAL-NERVOUS-SYSTEM; INTRANASAL INSULIN; PRECURSOR PROTEIN
AB Alzheimer's disease (AD) is the most common cause of dementia in North America. Growing evidence supports the concept that AD is fundamentally a metabolic disease that results in progressive impairment in the brain's capacity to utilize glucose and respond to insulin and insulin-like growth factor (IGF) stimulation. Moreover, the heterogeneous nature of AD is only partly explained by the brain's propensity to accumulate aberrantly processed, misfolded and aggregated oligomeric structural proteins, including amyloid-p peptides and hyperphosphorylated tau. Evidence suggests that other factors, including impaired energy metabolism, oxidative stress, neuroinflammation, insulin and IGF resistance, and insulin/IGF deficiency in the brain should be incorporated into an overarching hypothesis to develop more realistic diagnostic and therapeutic approaches to AD. In this review, the interrelationship between impaired insulin and IGF signalling and amyloid-beta pathology is discussed along with potential therapeutic approaches. Impairments in brain insulin/IGF signalling lead to increased expression of amyloid-beta precursor protein (A beta PP) and accumulation of A beta PP-A beta. In addition, they promote oxidative stress and deficits in energy metabolism, leading to the activation of pro-A beta PP-A beta-mediated neurodegeneration cascades. Although brain insulin/IGF resistance and deficiency can be induced by primary or secondary disease processes, the soaring rates of peripheral insulin resistance associated with obesity, diabetes mellitus and metabolic syndrome quite likely play major roles in the current AD epidemic. Both clinical and experimental data have linked chronic hyper-insulinaemia to cognitive impairment and neurodegeneration with increased A beta PP-A beta accumulation/reduced clearance in the CNS. Correspondingly, both the restoration of insulin responsiveness and the use of insulin therapy can lead to improved cognitive performance, although with variable effects on brain A beta PP-A beta load. On the other hand, experimental evidence supports the concept that the toxic effects of A beta PP-A beta can promote insulin resistance. Together, these findings suggest that a positive feedback loop of progressive neurodegeneration can develop whereby insulin resistance drives A beta PP-A beta accumulation, and A beta PP-A beta fibril toxicity drives brain insulin resistance. This phenomenon could explain why measuring A beta PP-A beta levels in cerebrospinal fluid or imaging of the brain has proven to be inadequate as a stand-alone biomarker for diagnosing AD, and why the clinical trial results of anti-A beta PP-A beta monotherapy have been disappointing. Instead, the aggregate data suggest that brain insulin resistance and deficiency must also be therapeutically targeted to halt AD progression or reverse its natural course. The positive therapeutic effects of different treatments that address the role of brain insulin/IGF resistance and deficiency, including the use of intranasal insulin delivery, incretins and insulin sensitizer agents are discussed along with potential benefits of lifestyle changes to modify risk for developing mild cognitive impairment or AD. Altogether, the data strongly support the notion that we must shift toward the implementation of multimodal rather than unimodal diagnostic and therapeutic strategies for AD.
C1 [de la Monte, Suzanne M.] Brown Univ, Dept Pathol, Rhode Isl Hosp, Providence, RI 02903 USA.
   [de la Monte, Suzanne M.] Brown Univ, Warren Alpert Med Sch, Providence, RI 02912 USA.
   [de la Monte, Suzanne M.] Brown Univ, Dept Neurosurg, Rhode Isl Hosp, Providence, RI 02912 USA.
   [de la Monte, Suzanne M.] Brown Univ, Dept Neurol, Rhode Isl Hosp, Providence, RI 02912 USA.
   [de la Monte, Suzanne M.] Brown Univ, Dept Med, Rhode Isl Hosp, Providence, RI 02912 USA.
C3 Brown University; Lifespan Health Rhode Island; Rhode Island Hospital;
   Brown University; Brown University; Lifespan Health Rhode Island; Rhode
   Island Hospital; Brown University; Lifespan Health Rhode Island; Rhode
   Island Hospital; Lifespan Health Rhode Island; Rhode Island Hospital;
   Brown University
RP de la Monte, SM (corresponding author), Brown Univ, Dept Pathol, Rhode Isl Hosp, 55 Claverick St,Room 419, Providence, RI 02903 USA.
EM Suzanne_DeLaMonte_MD@Brown.edu
RI de la monte, suzanne/L-7670-2019
FU National Institutes of Health [AA11431, AA12908, AA16260]
FX The author has no conflicts of interest that are directly relevant to
   the content of this review. Research support was provided by the
   National Institutes of Health through grants AA11431, AA12908 and
   AA16260.
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NR 175
TC 187
Z9 205
U1 0
U2 21
PU ADIS INT LTD
PI NORTHCOTE
PA 5 THE WAREHOUSE WAY, NORTHCOTE 0627, AUCKLAND, NEW ZEALAND
SN 0012-6667
EI 1179-1950
J9 DRUGS
JI Drugs
PY 2012
VL 72
IS 1
BP 49
EP 66
PG 18
WC Pharmacology & Pharmacy; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Toxicology
GA 878GG
UT WOS:000299242900004
PM 22191795
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Erlich, MN
   Ghidanac, D
   Mejia, SB
   Khan, TA
   Chiavaroli, L
   Zurbau, A
   Ayoub-Charette, S
   Almneni, A
   Messina, M
   Leiter, LA
   Bazinet, RP
   Jenkins, DJA
   Kendall, CWC
   Sievenpiper, JL
AF Erlich, M. N.
   Ghidanac, D.
   Blanco Mejia, S.
   Khan, T. A.
   Chiavaroli, L.
   Zurbau, A.
   Ayoub-Charette, S.
   Almneni, A.
   Messina, M.
   Leiter, L. A.
   Bazinet, R. P.
   Jenkins, D. J. A.
   Kendall, C. W. C.
   Sievenpiper, J. L.
TI A systematic review and meta-analysis of randomized trials of
   substituting soymilk for cow's milk and intermediate cardiometabolic
   outcomes: understanding the impact of dairy alternatives in the
   transition to plant-based diets on cardiometabolic health
SO BMC MEDICINE
LA English
DT Article
DE Soy protein; Soymilk; Cardiovascular disease; Systematic review;
   Meta-analysis; Randomized controlled feeding trials
ID SOY MILK; OXIDATIVE STRESS; BLOOD-PRESSURE; PUBLICATION BIAS; FINDINGS
   TABLES; PLASMA-LIPIDS; RISK-FACTORS; ALL-CAUSE; QUALITY; CONSUMPTION
AB Background Dietary guidelines recommend a shift to plant-based diets. Fortified soymilk, a prototypical plant protein food used in the transition to plant-based diets, usually contains added sugars to match the sweetness of cow's milk and is classified as an ultra-processed food. Whether soymilk can replace minimally processed cow's milk without the adverse cardiometabolic effects attributed to added sugars and ultra-processed foods remains unclear. We conducted a systematic review and meta-analysis of randomized controlled trials, to assess the effect of substituting soymilk for cow's milk and its modification by added sugars (sweetened versus unsweetened) on intermediate cardiometabolic outcomes. Methods MEDLINE, Embase, and the Cochrane Central Register of Controlled Trials were searched (through June 2024) for randomized controlled trials of >= 3 weeks in adults. Outcomes included established markers of blood lipids, glycemic control, blood pressure, inflammation, adiposity, renal disease, uric acid, and non-alcoholic fatty liver disease. Two independent reviewers extracted data and assessed risk of bias. The certainty of evidence was assessed using GRADE (Grading of Recommendations, Assessment, Development, and Evaluation). A sub-study of lactose versus sucrose outside of a dairy-like matrix was conducted to explore the role of sweetened soymilk which followed the same methodology. Results Eligibility criteria were met by 17 trials (n = 504 adults with a range of health statuses), assessing the effect of a median daily dose of 500 mL of soymilk (22 g soy protein and 17.2 g or 6.9 g/250 mL added sugars) in substitution for 500 mL of cow's milk (24 g milk protein and 24 g or 12 g/250 mL total sugars as lactose) on 19 intermediate outcomes. The substitution of soymilk for cow's milk resulted in moderate reductions in non-HDL-C (mean difference, - 0.26 mmol/L [95% confidence interval, - 0.43 to - 0.10]), systolic blood pressure (- 8.00 mmHg [- 14.89 to - 1.11]), and diastolic blood pressure (- 4.74 mmHg [- 9.17 to - 0.31]); small important reductions in LDL-C (- 0.19 mmol/L [- 0.29 to - 0.09]) and c-reactive protein (CRP) (- 0.82 mg/L [- 1.26 to - 0.37]); and trivial increases in HDL-C (0.05 mmol/L [0.00 to 0.09]). No other outcomes showed differences. There was no meaningful effect modification by added sugars across outcomes. The certainty of evidence was high for LDL-C and non-HDL-C; moderate for systolic blood pressure, diastolic blood pressure, CRP, and HDL-C; and generally moderate-to-low for all other outcomes. We could not conduct the sub-study of the effect of lactose versus added sugars, as no eligible trials could be identified. ConclusionsCurrent evidence provides a good indication that replacing cow's milk with soymilk (including sweetened soymilk) does not adversely affect established cardiometabolic risk factors and may result in advantages for blood lipids, blood pressure, and inflammation in adults with a mix of health statuses. The classification of plant-based dairy alternatives such as soymilk as ultra-processed may be misleading as it relates to their cardiometabolic effects and may need to be reconsidered in the transition to plant-based diets.
C1 [Erlich, M. N.; Ghidanac, D.; Blanco Mejia, S.; Khan, T. A.; Chiavaroli, L.; Zurbau, A.; Ayoub-Charette, S.; Leiter, L. A.; Bazinet, R. P.; Jenkins, D. J. A.; Kendall, C. W. C.; Sievenpiper, J. L.] Univ Toronto, Temerty Fac Med, Dept Nutr Sci, Toronto, ON, Canada.
   [Erlich, M. N.; Ghidanac, D.; Blanco Mejia, S.; Khan, T. A.; Chiavaroli, L.; Zurbau, A.; Ayoub-Charette, S.; Leiter, L. A.; Jenkins, D. J. A.; Kendall, C. W. C.; Sievenpiper, J. L.] St Michaels Hosp, Clin Nutr & Risk Factor Modificat Ctr, Toronto Knowledge Synth & Clin Trials Unit 3D, Toronto, ON, Canada.
   [Chiavaroli, L.; Leiter, L. A.; Jenkins, D. J. A.; Sievenpiper, J. L.] St Michaels Hosp, Li Ka Shing Knowledge Inst, Toronto, ON, Canada.
   [Almneni, A.] Royal Coll Surgeons Ireland, Dublin, Ireland.
   [Messina, M.] Soy Nutr Inst Global, Washington, DC USA.
   [Leiter, L. A.; Jenkins, D. J. A.; Sievenpiper, J. L.] Univ Toronto, Temerty Fac Med, Dept Med, Toronto, ON, Canada.
   [Leiter, L. A.; Jenkins, D. J. A.; Sievenpiper, J. L.] St Michaels Hosp, Dept Med, Div Endocrinol & Metab, Toronto, ON, Canada.
   [Kendall, C. W. C.] Univ Saskatchewan, Coll Pharm & Nutr, Saskatoon, SK, Canada.
C3 University of Toronto; University of Toronto; Saint Michaels Hospital
   Toronto; University of Toronto; Saint Michaels Hospital Toronto; Li Ka
   Shing Knowledge Institute; Royal College of Surgeons - Ireland;
   University of Toronto; University of Toronto; Saint Michaels Hospital
   Toronto; University of Saskatchewan
RP Sievenpiper, JL (corresponding author), Univ Toronto, Temerty Fac Med, Dept Nutr Sci, Toronto, ON, Canada.; Sievenpiper, JL (corresponding author), St Michaels Hosp, Clin Nutr & Risk Factor Modificat Ctr, Toronto Knowledge Synth & Clin Trials Unit 3D, Toronto, ON, Canada.; Sievenpiper, JL (corresponding author), St Michaels Hosp, Li Ka Shing Knowledge Inst, Toronto, ON, Canada.; Sievenpiper, JL (corresponding author), Univ Toronto, Temerty Fac Med, Dept Med, Toronto, ON, Canada.; Sievenpiper, JL (corresponding author), St Michaels Hosp, Dept Med, Div Endocrinol & Metab, Toronto, ON, Canada.
EM john.sievenpiper@utoronto.ca
RI Leiter, Lawrence/AAG-4059-2020; Rao, Jagadeesh/GRN-8594-2022;
   Sievenpiper, John/JVN-7555-2024; Jenkins, David/A-1992-2009
FU Canadian Nutrition Society (CNS), Quebec City, Canada [2023]
FX Aspects of this work were presented at the following conferences:
   Canadian Nutrition Society (CNS), Quebec City, Canada, May 4-6, 2023;
   40th International Symposium on Diabetes and Nutrition, Pula, Croatia,
   June 15-18, 2023; and Nutrition 2023-American Society for Nutrition
   (ASN), Boston, USA, July 22-25, 2023.
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NR 83
TC 4
Z9 4
U1 0
U2 4
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1741-7015
J9 BMC MED
JI BMC Med.
PD AUG 22
PY 2024
VL 22
IS 1
AR 336
DI 10.1186/s12916-024-03524-7
PG 16
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA D4K7M
UT WOS:001295894000001
PM 39169353
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Rahman, H
   Ryan, M
   Lumley, M
   Modi, B
   McConkey, H
   Ellis, H
   Scannell, C
   Clapp, B
   Marber, M
   Webb, A
   Chiribiri, A
   Perera, D
AF Rahman, Haseeb
   Ryan, Matthew
   Lumley, Matthew
   Modi, Bhavik
   McConkey, Hannah
   Ellis, Howard
   Scannell, Cian
   Clapp, Brian
   Marber, Michael
   Webb, Andrew
   Chiribiri, Amedeo
   Perera, Divaka
TI Coronary Microvascular Dysfunction Is Associated With Myocardial
   Ischemia and Abnormal Coronary Perfusion During Exercise
SO CIRCULATION
LA English
DT Article
DE coronary artery disease; exercise; microvascular angina; perfusion
   imaging
ID ARTERY-DISEASE; SYNDROME-X; FLOW RESERVE; BLOOD-FLOW; ANGINA; HEART;
   RESISTANCE; DIAGNOSIS
AB BACKGROUND: Coronary microvascular dysfunction (MVD) is defined by impaired flow augmentation in response to a pharmacological vasodilator in the presence of nonobstructive coronary artery disease. It is unknown whether diminished coronary vasodilator response correlates with abnormal exercise physiology or inducible myocardial ischemia.
   METHODS: Patients with angina and nonobstructive coronary artery disease had simultaneous coronary pressure and flow velocity measured using a dual sensor-tipped guidewire during rest, supine bicycle exercise, and adenosine-mediated hyperemia. Microvascular resistance (MR) was calculated as coronary pressure divided by flow velocity. Wave intensity analysis quantified the proportion of accelerating wave energy (perfusion efficiency). Global myocardial blood flow and subendocardial:subepicardial perfusion ratio were quantified using 3-Tesla cardiac magnetic resonance imaging during hyperemia and rest; inducible ischemia was defined as hyperemic subendocardial:subepicardial perfusion ratio <1.0. Patients were classified as having MVD if coronary flow reserve <2.5 and controls if coronary flow reserve >= 2.5, with researchers blinded to the classification.
   RESULTS: Eighty-five patients were enrolled (78% female, 5710 years), 45 (53%) were classified as having MVD. Of the MVD group, 82% had inducible ischemia compared with 22% of controls (P<0.001); global myocardial perfusion reserve was 2.01 +/- 0.41 and 2.68 +/- 0.49 (P<0.001). In controls, coronary perfusion efficiency improved from rest to exercise and was unchanged during hyperemia (59 +/- 11% vs 65 +/- 14% vs 57 +/- 18%; P=0.02 and P=0.14). In contrast, perfusion efficiency decreased during both forms of stress in MVD (61 +/- 12 vs 44 +/- 10 vs 42 +/- 11%; both P<0.001). Among patients with a coronary flow reserve <2.5, 62% had functional MVD, with normal minimal MR (hyperemic MR<2.5 mmHg/cm/s), and 38% had structural MVD with elevated hyperemic MR. Resting MR was lower in those with functional MVD (4.2 +/- 1.0 mmHg/cm/s) than in those with structural MVD (6.9 +/- 1.7 mmHg/cm/s) or controls (7.3 +/- 2.2 mmHg/cm/s; both P<0.001). During exercise, the structural group had a higher systolic blood pressure (188 +/- 25 mmHg) than did those with functional MVD (161 +/- 27 mmHg; P=0.004) and controls (156 +/- 30 mmHg; P<0.001). Functional and structural MVD had similar stress myocardial perfusion and exercise perfusion efficiency values.
   CONCLUSION: In patients with angina and nonobstructive coronary artery disease, diminished coronary flow reserve characterizes a cohort with inducible ischemia and a maladaptive physiological response to exercise. We have identified 2 endotypes of MVD with distinctive systemic vascular responses to exercise; whether endotypes have a different prognosis or require different treatments merits further investigation.
C1 [Rahman, Haseeb; Ryan, Matthew; Lumley, Matthew; Modi, Bhavik; McConkey, Hannah; Ellis, Howard; Clapp, Brian; Marber, Michael; Webb, Andrew; Perera, Divaka] Kings Coll London, British Heart Fdn Ctr Res Excellence, Sch Cardiovasc Med, London, England.
   [Rahman, Haseeb; Ryan, Matthew; Lumley, Matthew; Modi, Bhavik; McConkey, Hannah; Ellis, Howard; Clapp, Brian; Marber, Michael; Webb, Andrew; Perera, Divaka] Kings Coll London, British Heart Fdn Ctr Res Excellence, Sch Sci, London, England.
   [Scannell, Cian; Chiribiri, Amedeo] Kings Coll London, Biomed Engn & Imaging Sci, London, England.
C3 University of London; King's College London; University of London;
   King's College London; University of London; King's College London
RP Perera, D (corresponding author), St Thomas Hosp, Dept Cardiol, London SE1 7EH, England.
EM divaka.perera@kcl.ac.uk
RI marber, michael/AAW-7916-2021; Chiribiri, Amedeo/T-2771-2019; Scannell,
   Cian/AAO-5657-2020; Webb, Andrew/G-9642-2016
OI Ellis, Howard/0000-0001-9004-9964; Webb, Andrew/0000-0002-8109-1877;
   Modi, Bhavik/0000-0002-9413-8291; Ryan, Matthew/0000-0001-8256-195X;
   Chiribiri, Amedeo/0000-0003-3394-4289; Scannell,
   Cian/0000-0001-9240-793X; Marber, Michael/0000-0002-3463-7128
FU British Heart Foundation [FS/16/49/32320, FS/13/15/30026]; National
   Institute for Health Research (Biomedical Research Centre award)
FX This work was supported by the British Heart Foundation (primarily
   through the fellowships FS/16/49/32320 and FS/13/15/30026) and by the
   National Institute for Health Research (through the Biomedical Research
   Centre award to King's College London and Guy's and St Thomas'
   Hospital).
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NR 41
TC 144
Z9 148
U1 0
U2 11
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0009-7322
EI 1524-4539
J9 CIRCULATION
JI Circulation
PD NOV 26
PY 2019
VL 140
IS 22
BP 1805
EP 1816
DI 10.1161/CIRCULATIONAHA.119.041595
PG 12
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA JV5DL
UT WOS:000502385200011
PM 31707835
OA Green Published, Green Submitted, hybrid
DA 2025-06-11
ER

PT J
AU Zhou, HY
   Toshiyoshi, M
   Zhao, WL
   Zhao, Y
   Zhao, Y
AF Zhou, Haiyan
   Toshiyoshi, Maeda
   Zhao, Wenli
   Zhao, Ye
   Zhao, Yan
TI Statins on nonalcoholic fatty liver disease: A systematic review and
   meta-analysis of 14 RCTs
SO MEDICINE
LA English
DT Review
DE meta-analysis; NAFLD; NASH; statins; systematic review
ID METABOLIC SYNDROME; OXIDATIVE STRESS; STEATOHEPATITIS; PATHOGENESIS;
   MITOCHONDRIAL; SIMVASTATIN; SITAGLIPTIN
AB Background:The prevalence of nonalcoholic fatty liver disease (NAFLD) is rising rapidly in the world. Our aim is to investigate the efficacy and safety of statins in the treatment of NAFLD. Methods:This study was conducted by searching The National Library of Medicine, Cochrane Library, China National Knowledge Infrastructure, Web of Science, and Wanfang Data Knowledge Service Platform databases. Literature data are expressed as mean difference (MD) and 95% confidence intervals (CIs) or relative risk and 95% CI. For I-2 > 50% trials, random effect model is used for statistical analysis, otherwise fixed effect model is used. Results:Fourteen studies are selected for this meta-analysis, which includes totally 534 patients in the treatment group and 527 patients in the control group. As a result, 5 studies show that the total effective rate of the treatment group is 17% higher than that of the control group (Z = 2.11, relative risk = 1.17, 95% CI: [1.01-1.35]). Twelve studies show that alanine aminotransferase levels of the experimental group are lower than that of the control group (Z = 2.63, P = .009, MD = -5.53, 95% CI: [-9.64 to -1.41]). Eleven studies show that aspartate transaminase levels of the experimental group are lower than that of the control group (Z = 2.01, P = .04, MD = -3.43, 95% CI: [-6.77 to -0.08]). Six studies show that alkaline phosphatase levels of the experimental group are lower than that of the control group (Z = 0.79, P = .43, MD = -3.46, 95% CI: [-12.08 to 5.16]). Eight studies show that gamma-glutamyl transpeptidase levels of the experimental group are lower than that of the control group (Z = 2.04, P = .04, MD = -4.05, 95% CI: [-7.96 to -0.15]). Thirteen studies show that triglyceride levels of the experimental group are lower than that of the control group (Z = 4.15, P < .0001, MD = -0.94, 95% CI: [-1.39 to -0.50]). Eleven studies show that the total cholesterol levels of the experimental group are lower than that of the control group (Z = 5.42, P < .00001, MD = -1.51, 95% CI: [-2.05 to -0.96]). Seven studies show that low-density lipoprotein-cholesterol levels of the experimental group are lower than that of the control group (Z = 5.00, P < .00001, MD = -0.85, 95% CI: [-1.18 to -0.52]). Conclusion:Statins can significantly reduce liver biochemical indicators in patients with NAFLD.
C1 [Zhou, Haiyan] Yueyang Vocat Tech Coll, Dept Med, Yueyang, Peoples R China.
   [Toshiyoshi, Maeda] Shandong Univ Tradit Chinese Med, Int Educ Coll, Jinan, Peoples R China.
   [Zhao, Wenli] Saga Univ, Saga Univ Hosp, Liver Ctr, Saga, Japan.
   [Zhao, Ye] Krirk Univ, Int Coll, Dept Publ Hlth, Bangkok 10220, Thailand.
   [Zhao, Yan] Krirk Univ, Int Coll, Dept Publ Hlth, Bangkok, Thailand.
C3 Shandong University of Traditional Chinese Medicine; Saga University;
   Krirk University; Krirk University
RP Zhao, Y (corresponding author), Krirk Univ, Int Coll, Dept Publ Hlth, Bangkok 10220, Thailand.
EM 2283945668@qq.com; mar31880@gmail.com; 820761907@qq.com;
   820761907@qq.com; 820761907@qq.com
RI Zhao, Yan/A-1136-2009; Zhao, Wenli/ABK-2519-2022
FU 2022 Scientific Research Project of Hunan Provincial Education
   Department [22C1372]
FX This project was supported by the 2022 Scientific Research Project of
   Hunan Provincial Education Department (22C1372).
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NR 42
TC 12
Z9 12
U1 1
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD JUN 30
PY 2023
VL 102
IS 26
DI 10.1097/MD.0000000000033981
PG 9
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA L2QA5
UT WOS:001021744000019
PM 37390233
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Yamagishi, K
   Tsukamoto, I
   Nakamura, F
   Hashimoto, K
   Ohtani, K
   Akagi, M
AF Yamagishi, Kotaro
   Tsukamoto, Ichiro
   Nakamura, Fumihisa
   Hashimoto, Kazuhiko
   Ohtani, Kazuhiro
   Akagi, Masao
TI Activation of the renin-angiotensin system in mice aggravates mechanical
   loading-induced knee osteoarthritis
SO EUROPEAN JOURNAL OF HISTOCHEMISTRY
LA English
DT Article
DE Osteoarthritis; hypertension; RAS; AT1R; mechanical stress
ID TISSUE-SPECIFIC EXPRESSION; II TYPE-2 RECEPTOR; METABOLIC SYNDROME;
   TRANSGENIC MICE; UP-REGULATION; CARTILAGE; BONE; HYPERTROPHY;
   PROGRESSION; INCREASES
AB Epidemiological studies have shown an association between hypertension and knee osteoarthritis (OA). The purpose of this study was to investigate whether activation of the renin-angiotensin system (RAS) can aggravate mechanical loading-induced knee OA in mice. Eight-week-old male Tsukuba hypertensive mice (THM) and C57BL/6 mice were divided into four groups: i) running THM group, running C57BL/6 mice group, non-running THM group, and iv) non-running C57BL/6 mice group. Mice in the running group were forced to run (25 m/min, 30 min/day, 5 days/week) on a treadmill. All mice in the four groups (n=10 in each group) were euthanized after 0, 2, 4, 6, or 8 weeks of running or natural breeding. Cartilage degeneration in the left knees was histologically evaluated using the modified Mankin score. Expression of Col X, MMP-13, angiotensin type 1 receptor (AT1R), and AT2R was examined immunohistochemically. To study the effects of stimulation of the AT1R in chondrocytes by mechanical loading and/or Angiotensin II (AngII) on transduction of intracellular signals, phosphorylation levels of JNK and Src were measured in bovine articular chondrocytes cultured in three-dimensional agarose scaffolds. After 4 weeks, the mean Mankin score for the lateral femoral condylar cartilage was significantly higher in the THM nmning group than in the C57BL/6 running group and non-numing groups. AT1R and AT2R expression was not detected at 0 weeks in any group but was noted after 4 weeks in the THM running group. AT1R expression was also noted at 8 weeks in the C57BL/6 running group. The expression levels of AT1R, COL X, and MMP-13 in chondrocytes were significantly higher in the THM running group than in the control groups. Positive significant correlations were noted between the Mankin score and the rate of AT1R-inununopositive cells, between the rates of AT1R- and Col X-positive cells. and between the rates of AT1R and AT2R-positive cells. The phosphorylation level of JNK was increased by cyclic compression loading or addition of AngII to the cultured chondrocytes and was reversed by pretreatment with an AT1R blocker. A synergistic effect on JNK phosphorylation was observed between compression loading and AngII addition. Transgene activation of renin and angiotensinogen aggravated mechanical load-induced knee OA in mice. These findings suggest that AT1R expression in chondrocytes is associated with early knee OA and plays a role in the progression of cartilage degeneration. The RAS may be a common molecular mechanism involved in the pathogenesis of hypertension and knee OA.
C1 [Yamagishi, Kotaro; Tsukamoto, Ichiro; Nakamura, Fumihisa; Hashimoto, Kazuhiko; Ohtani, Kazuhiro; Akagi, Masao] Kindai Univ Hosp, Dept Orthopaed Surg, 377-2 Ohno Higashi, Osaka, Osaka 5898511, Japan.
RP Akagi, M (corresponding author), Kindai Univ Hosp, Dept Orthopaed Surg, 377-2 Ohno Higashi, Osaka, Osaka 5898511, Japan.
EM makagi@med.kindai.ac.jp
RI Tsukamoto, Ichiro/LBH-2339-2024
OI Tsukamoto, Ichiro/0000-0002-2054-0384
FU Ministry of Education, Culture, Sports, Science and Technology of Japan
   [16K10923]; Grants-in-Aid for Scientific Research [16K10923] Funding
   Source: KAKEN
FX This work was partially supported by the Grant-in-Aid from the Ministry
   of Education, Culture, Sports, Science and Technology of Japan (Grant
   No. 16K10923).
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NR 49
TC 21
Z9 23
U1 1
U2 4
PU PAGEPRESS PUBL
PI PAVIA
PA MEDITGROUP, VIA G BELLI, 4, PAVIA, 27100, ITALY
SN 1121-760X
EI 2038-8306
J9 EUR J HISTOCHEM
JI Eur. J. Histochem.
PY 2018
VL 62
IS 3
BP 177
EP 187
AR 2930
DI 10.4081/ejh.2018.2930
PG 11
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA HG0FW
UT WOS:000454619200001
PM 30043596
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Taneja, SK
   Mandal, R
AF Taneja, Satish Kumar
   Mandal, Reshu
TI Assessment of minerals in obesity-related diseases in the Chandigarh
   (India) population
SO BIOLOGICAL TRACE ELEMENT RESEARCH
LA English
DT Review
DE minerals (Zn, Cu, Mg and Mn); obesity; diabetes; osteoarthritis;
   rheumatoid arthritis; osteoarthritis with diabetes
ID TUMOR-NECROSIS-FACTOR; RHEUMATOID-ARTHRITIS; DIABETES-MELLITUS;
   TRACE-ELEMENTS; PLASMA ZINC; SUPEROXIDE-DISMUTASE; ADIPOSE-TISSUE;
   METABOLIC SYNDROME; CONNECTIVE-TISSUE; OXIDATIVE STRESS
AB Excessive Zn but normal Cu and Mg in the staple food consumed by the people of Chandigarh ( Union territory and capital of Punjab and Haryana States of India) has been considered to be the major risk factor for the prevalence of obesity (33.15%) and obesity-related diseases in this region. Therefore, in the present investigations, in obesity-related diseases, the status of these minerals was estimated in their tissues, including hair, nails, and blood serum and urine, and compared with those of normal subjects. They were grouped as: normal subjects in control Group A, middle-aged diabetics in Group D-M, older diabetics in Group DO, and diabetics with osteoarthritis in Group D+OA, osteoarthritis in Group OA and rheumatoid arthritis in Group RA, respectively. The results evaluated in the order as: hair Zn, group D+OA>D-M>OA>A (control)>RA>D-O (p<0.001); hair Cu, group A (control)>D-M>OA> D+OA>D-O>RA (p<0.001); hair Mg, group A (control)>D-M>OA>D+OA>RA>D-O (p<0.001, 0.01); hair Mn, group A (control)>RA>OA>D-OA>D-M>D-O (p<0.001); nail Zn, group D-M>D+OA>OA>A (control)>RA>D-O (p<0.001, 0.05); nail Cu, group A (control)> OA>D-M>D+OA>RA>D-O (p<0.001); nail Mg, group A (control)>OA>D-M>D-O>D+OA>RA (p<0.001); nail Mn, group A (control)>RA>OA>D+OA>D-M>D-O (p<0.01); urine Zn, group D-O>D-M>D+OA>A (control)>RA>OA (p<0.01); urine Cu, group RA>D+OA>D-O>OA> D-M>A (control) (p<0.001); urine Mg, group RA>OA>D+OA>D-O>D-M>A (control; p<0.001); urine Mn, group D-O>D-M>OA>D+OA>RA>A (control; p<0.001), respectively. The analysis of the mineral status in serum of diabetics further showed their highly significant rise from lower mean age subgroup to higher mean age subgroup than their control counter parts (p<0.001, 0.01, and 0.05) with coincident deficiencies of Cu, Mg, and Mn in their tissues. This study would be helpful considering the status of minerals in these obesity-related diseases depending on the choice of the food consumed to improve the quality of life and prognosis for the diseases.
C1 [Taneja, Satish Kumar; Mandal, Reshu] Panjab Univ, Dept Zool, Chandigarh 160014, India.
C3 Panjab University
RP Taneja, SK (corresponding author), Panjab Univ, Dept Zool, Chandigarh 160014, India.
EM sktaneja@gmail.com
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NR 108
TC 5
Z9 5
U1 0
U2 5
PU HUMANA PRESS INC
PI TOTOWA
PA 999 RIVERVIEW DRIVE SUITE 208, TOTOWA, NJ 07512 USA
SN 0163-4984
EI 1559-0720
J9 BIOL TRACE ELEM RES
JI Biol. Trace Elem. Res.
PD FEB
PY 2008
VL 121
IS 2
BP 106
EP 123
DI 10.1007/s12011-007-8035-1
PG 18
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 254UY
UT WOS:000252614700002
PM 17952386
DA 2025-06-11
ER

PT J
AU San-Millan, I
AF San-Millan, Inigo
TI The Key Role of Mitochondrial Function in Health and Disease
SO ANTIOXIDANTS
LA English
DT Review
DE mitochondrial dysfunction; cellular bioenergetics; diabetes;
   cardiovascular disease; cancer; Alzheimer's disease; metabolic
   flexibility; exercise
ID FATTY-ACID-METABOLISM; HUMAN SKELETAL-MUSCLE; BRAIN INSULIN-RESISTANCE;
   PHYSICAL-ACTIVITY; OXIDATIVE STRESS; ALZHEIMERS-DISEASE;
   CARDIOVASCULAR-DISEASE; IN-VIVO; DIABETES-MELLITUS; RESPIRATORY-CHAIN
AB The role of mitochondrial function in health and disease has become increasingly recognized, particularly in the last two decades. Mitochondrial dysfunction as well as disruptions of cellular bioenergetics have been shown to be ubiquitous in some of the most prevalent diseases in our society, such as type 2 diabetes, cardiovascular disease, metabolic syndrome, cancer, and Alzheimer's disease. However, the etiology and pathogenesis of mitochondrial dysfunction in multiple diseases have yet to be elucidated, making it one of the most significant medical challenges in our history. However, the rapid advances in our knowledge of cellular metabolism coupled with the novel understanding at the molecular and genetic levels show tremendous promise to one day elucidate the mysteries of this ancient organelle in order to treat it therapeutically when needed. Mitochondrial DNA mutations, infections, aging, and a lack of physical activity have been identified to be major players in mitochondrial dysfunction in multiple diseases. This review examines the complexities of mitochondrial function, whose ancient incorporation into eukaryotic cells for energy purposes was key for the survival and creation of new species. Among these complexities, the tightly intertwined bioenergetics derived from the combustion of alimentary substrates and oxygen are necessary for cellular homeostasis, including the production of reactive oxygen species. This review discusses different etiological mechanisms by which mitochondria could become dysregulated, determining the fate of multiple tissues and organs and being a protagonist in the pathogenesis of many non-communicable diseases. Finally, physical activity is a canonical evolutionary characteristic of humans that remains embedded in our genes. The normalization of a lack of physical activity in our modern society has led to the perception that exercise is an "intervention". However, physical activity remains the modus vivendi engrained in our genes and being sedentary has been the real intervention and collateral effect of modern societies. It is well known that a lack of physical activity leads to mitochondrial dysfunction and, hence, it probably becomes a major etiological factor of many non-communicable diseases affecting modern societies. Since physical activity remains the only stimulus we know that can improve and maintain mitochondrial function, a significant emphasis on exercise promotion should be imperative in order to prevent multiple diseases. Finally, in populations with chronic diseases where mitochondrial dysfunction is involved, an individualized exercise prescription should be crucial for the "metabolic rehabilitation" of many patients. From lessons learned from elite athletes (the perfect human machines), it is possible to translate and apply multiple concepts to the betterment of populations with chronic diseases.
C1 [San-Millan, Inigo] Univ Colorado, Dept Human Physiol & Nutr, Colorado Springs, CO 80198 USA.
   [San-Millan, Inigo] Univ Colorado Anschutz Med Campus, Dept Med, Div Endocrinol Metab & Diabet, Aurora, CO 80045 USA.
   [San-Millan, Inigo] Univ Colorado Anschutz Med Campus, Dept Med, Div Med Oncol, Aurora, CO 80045 USA.
C3 University of Colorado System; University of Colorado at Colorado
   Springs; University of Colorado System; University of Colorado Anschutz
   Medical Campus; University of Colorado System; University of Colorado
   Anschutz Medical Campus
RP San-Millan, I (corresponding author), Univ Colorado, Dept Human Physiol & Nutr, Colorado Springs, CO 80198 USA.; San-Millan, I (corresponding author), Univ Colorado Anschutz Med Campus, Dept Med, Div Endocrinol Metab & Diabet, Aurora, CO 80045 USA.; San-Millan, I (corresponding author), Univ Colorado Anschutz Med Campus, Dept Med, Div Med Oncol, Aurora, CO 80045 USA.
EM isanmill@uccs.edu
OI San-Millan, Inigo/0000-0002-7975-917X
FU IS-M Cellular Metabolism Laboratory funds.
FX This study was funded with IS-M Cellular Metabolism Laboratory funds.
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NR 327
TC 104
Z9 108
U1 29
U2 90
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD APR
PY 2023
VL 12
IS 4
AR 782
DI 10.3390/antiox12040782
PG 30
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA E7MO4
UT WOS:000977344100001
PM 37107158
OA Green Published, gold
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Vecchi, C
   Montosi, G
   Garuti, C
   Corradini, E
   Sabelli, M
   Canali, S
   Pietrangelo, A
AF Vecchi, Chiara
   Montosi, Giuliana
   Garuti, Cinzia
   Corradini, Elena
   Sabelli, Manuela
   Canali, Susanna
   Pietrangelo, Antonello
TI Gluconeogenic Signals Regulate Iron Homeostasis via Hepcidin in Mice
SO GASTROENTEROLOGY
LA English
DT Article
DE Peroxisome Proliferator-Activated Receptor-Gamma Co-activator 1-Alpha
   (PGC1A); cAMP Response Element-Binding Protein-H (CREBH); Glucagon;
   Mouse Model
ID ENDOPLASMIC-RETICULUM STRESS; ELEMENT-BINDING PROTEIN; FATTY
   LIVER-DISEASE; HEPATIC GLUCONEOGENESIS; TRANSCRIPTION FACTOR;
   GLUCOSE-METABOLISM; COACTIVATOR PGC-1; MOUSE-LIVER; IN-VIVO; EXPRESSION
AB BACKGROUND & AIMS: Hepatic gluconeogenesis provides fuel during starvation, and is abnormally induced in obese individuals or those with diabetes. Common metabolic disorders associated with active gluconeogenesis and insulin resistance (obesity, metabolic syndrome, diabetes, and nonalcoholic fatty liver disease) have been associated with alterations in iron homeostasis that disrupt insulin sensitivity and promote disease progression. We investigated whether gluconeogenic signals directly control Hepcidin, an important regulator of iron homeostasis, in starving mice (a model of persistently activated gluconeogenesis and insulin resistance).METHODS: We investigated hepatic regulation of Hepcidin expression in C57BL/6Crl, 129S2/SvPas, BALB/c, and Creb3l3-/- null mice. Mice were fed a standard, iron-balanced chow diet or an iron-deficient diet for 9 days before death, or for 7 days before a 24- to 48-hour starvation period; liver and spleen tissues then were collected and analyzed by quantitative reverse-transcription polymerase chain reaction and immunoblot analyses. Serum levels of iron, hemoglobin, Hepcidin, and glucose also were measured. We analyzed human hepatoma (HepG2) cells and mouse primary hepatocytes to study transcriptional control of Hamp (the gene that encodes Hepcidin) in response to gluconeogenic stimuli using small interfering RNA, luciferase promoter, and chromatin immunoprecipitation analyses. RESULTS: Starvation led to increased transcription of the gene that encodes phosphoenolpyruvate carboxykinase 1 (a protein involved in gluconeogenesis) in livers of mice, increased levels of Hepcidin, and degradation of Ferroportin, compared with nonstarved mice. These changes resulted in hypoferremia and iron retention in liver tissue. Livers of starved mice also had increased levels of Ppargc1a mRNA and Creb3l3 mRNA, which encode a transcriptional co-activator involved in energy metabolism and a liver-specific transcription factor, respectively. Glucagon and a cyclic adenosine monophosphate analog increased promoter activity and transcription of Hampin cultured liver cells; levels of Hamp were reduced after administration of small interfering RNAs against Ppargc1a and Creb3l3. PPARGC1A and CREB3L3 bound the Hamp promoter to activate its transcription in response to a cyclic adenosine monophosphate analog. Creb3l3-/-mice did not up-regulate Hamp or become hypoferremic during starvation. CONCLUSIONS: We identified a link between glucose and iron homeostasis, showing that Hepcidin is a gluconeogenic sensor in mice during starvation. This response is involved in hepatic metabolic adaptation to increased energy demands; it preserves tissue iron for vital activities during food withdrawal, but can cause excessive iron retention and hypoferremia in disorders with persistently activated gluconeogenesis and insulin resistance.
C1 [Vecchi, Chiara; Montosi, Giuliana; Garuti, Cinzia; Corradini, Elena; Sabelli, Manuela; Canali, Susanna; Pietrangelo, Antonello] Univ Hosp Modena, Ctr Hemochromatosis & Metab Liver Dis, Dept Med & Surg Sci, I-41100 Modena, Italy.
C3 Universita di Modena e Reggio Emilia; Universita di Modena e Reggio
   Emilia Hospital
RP Pietrangelo, A (corresponding author), Univ Hosp Modena, Div Internal Med 2, Via Pozzo 71, I-41100 Modena, Italy.
EM antonello.pietrangelo@unimore.it
RI Vecchi, Chiara/C-1552-2014; Pietrangelo, Antonello/K-1517-2016;
   Corradini, Elena/O-4167-2016
OI Pietrangelo, Antonello/0000-0002-7411-935X; VECCHI,
   Chiara/0000-0001-7761-4922; Corradini, Elena/0000-0001-9477-2164
FU Telethon grant [GGP10233]; PRIN grant [2010REYFZH_005]
FX This work was supported by Telethon grant GGP10233 and PRIN grant
   2010REYFZH_005 to AP.
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NR 50
TC 107
Z9 119
U1 0
U2 18
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0016-5085
EI 1528-0012
J9 GASTROENTEROLOGY
JI Gastroenterology
PD APR
PY 2014
VL 146
IS 4
BP 1060
EP U618
DI 10.1053/j.gastro.2013.12.016
PG 13
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA AD4XH
UT WOS:000333254500035
PM 24361124
OA hybrid, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Sampa, MB
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AF Sampa, Masuda Begum
   Hossain, Nazmul
   Hoque, Rakibul
   Islam, Rafiqul
   Yokota, Fumihiko
   Nishikitani, Mariko
   Ahmed, Ashir
TI Blood Uric Acid Prediction With Machine Learning: Model Development and
   Performance Comparison
SO JMIR MEDICAL INFORMATICS
LA English
DT Article
DE blood uric acid; urban corporate population; machine learning;
   noncommunicable diseases; Bangladesh; boosted decision tree regression
   model
ID CROSS-VALIDATION; RANDOM FOREST; CLASSIFICATION; REGRESSION;
   HYPERURICEMIA; HYPERTENSION; HEALTH; ADOLESCENTS; EVOLUTION; DIAGNOSIS
AB Background: Uric acid is associated with noncommunicable diseases such as cardiovascular diseases, chronic kidney disease, coronary artery disease, stroke, diabetes, metabolic syndrome, vascular dementia, and hypertension. Therefore, uric acid is considered to be a risk factor for the development of noncommunicable diseases. Most studies on uric acid have been performed in developed countries, and the application of machine-learning approaches in uric acid prediction in developing countries is rare. Different machine-learning algorithms will work differently on different types of data in various diseases; therefore, a different investigation is needed for different types of data to identify the most accurate algorithms. Specifically, no study has yet focused on the urban corporate population in Bangladesh, despite the high risk of developing noncommunicable diseases for this population.
   Objective: The aim of this study was to develop a model for predicting blood uric acid values based on basic health checkup test results, dietary information, and sociodemographic characteristics using machine-learning algorithms. The prediction of health checkup test measurements can be very helpful to reduce health management costs.
   Methods: Various machine-learning approaches were used in this study because clinical input data are not completely independent and exhibit complex interactions. Conventional statistical models have limitations to consider these complex interactions, whereas machine learning can consider all possible interactions among input data. We used boosted decision tree regression, decision forest regression, Bayesian linear regression, and linear regression to predict personalized blood uric acid based on basic health checkup test results, dietary information, and sociodemographic characteristics. We evaluated the performance of these five widely used machine-learning models using data collected from 271 employees in the Grameen Bank complex of Dhaka, Bangladesh.
   Results: The mean uric acid level was 6.63 mg/dL, indicating a borderline result for the majority of the sample (normal range <7.0 mg/dL). Therefore, these individuals should be monitoring their uric acid regularly. The boosted decision tree regression model showed the best performance among the models tested based on the root mean squared error of 0.03, which is also better than that of any previously reported model.
   Conclusions: A uric acid prediction model was developed based on personal characteristics, dietary information, and some basic health checkup measurements. This model will be useful for improving awareness among high-risk individuals and populations, which can help to save medical costs. A future study could include additional features (eg, work stress, daily physical activity, alcohol intake, eating red meat) in improving prediction.
C1 [Sampa, Masuda Begum; Ahmed, Ashir] Kyushu Univ, Dept Adv Informat Technol, Fukuoka, Japan.
   [Hossain, Nazmul] Univ Dhaka, Fac Business Studies, Dept Mkt, Dhaka, Bangladesh.
   [Hoque, Rakibul] Emporia State Univ, Sch Business, Emporia, KS 66801 USA.
   [Islam, Rafiqul; Nishikitani, Mariko] Kyushu Univ Hosp, Med Informat Ctr, Fukuoka, Japan.
   [Yokota, Fumihiko] Kyushu Univ, Inst Decis Sci Sustainable Soc, Fukuoka, Japan.
C3 Kyushu University; University of Dhaka; Kyushu University; Kyushu
   University
RP Sampa, MB (corresponding author), Kyushu Univ, Dept Adv Informat Technol, Nishi Ku, 744 Motooka, Fukuoka, Japan.
EM sampa@kyudai.jp
RI Sampa, Masuda/JYP-7499-2024; Yokota, Fumihiko/KTI-8230-2024; HOQUE, MD
   RAKIBUL/N-9368-2013
OI Hossain, Md. Nazmul/0000-0003-0574-5223; Ahmed,
   Ashir/0000-0002-8125-471X; HOQUE, MD RAKIBUL/0000-0002-4516-1081;
   Islam-Maruf, Rafiqul/0000-0002-6275-9472; Nishikitani,
   Mariko/0000-0001-5181-0263
FU Japan Society for the Promotion of Science (JSPS) KAKENHI [18K11529];
   Future Earth Research Fund [18-161009264]; Grants-in-Aid for Scientific
   Research [18K11529] Funding Source: KAKEN
FX This research was supported by multiple organizations. Japan Society for
   the Promotion of Science (JSPS) KAKENHI (grant number 18K11529) and the
   Future Earth Research Fund (grant number 18-161009264) jointly financed
   the core research. The Institute of Decision Science for a Sustainable
   Society (IDS3), Kyushu University, Japan, provided travel expenses for
   data collection, and Grameen Communications, Bangladesh, provided
   technical assistance.
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NR 69
TC 11
Z9 11
U1 3
U2 19
PU JMIR PUBLICATIONS, INC
PI TORONTO
PA 130 QUEENS QUAY E, STE 1102, TORONTO, ON M5A 0P6, CANADA
EI 2291-9694
J9 JMIR MED INF
JI JMIR Med. Inf.
PD OCT
PY 2020
VL 8
IS 10
AR e18331
DI 10.2196/18331
PG 13
WC Medical Informatics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Informatics
GA OO6FW
UT WOS:000587474400009
PM 33030442
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Amor, S
   González-Hedström, D
   Martín-Carro, B
   Inarejos-García, AM
   Almodóvar, P
   Prodanov, M
   García-Villalón, AL
   Granado, M
AF Amor, Sara
   Gonzalez-Hedstrom, Daniel
   Martin-Carro, Beatriz
   Manuel Inarejos-Garcia, Antonio
   Almodovar, Paula
   Prodanov, Marin
   Luis Garcia-Villalon, Angel
   Granado, Miriam
TI Beneficial Effects of an Aged Black Garlic Extract in the Metabolic and
   Vascular Alterations Induced by a High Fat/Sucrose Diet in Male Rats
SO NUTRIENTS
LA English
DT Article
DE aged black garlic; metabolic syndrome; obesity; adipose tissue; insulin;
   cardiovascular; rat
ID HIGH-FAT DIET; S-ALLYL CYSTEINE; OXIDATIVE STRESS; GENE-EXPRESSION;
   ADIPOSE-TISSUE; IN-VITRO; INSULIN; RECEPTOR; ALLYLCYSTEINE; INFLAMMATION
AB Aged black garlic (ABG) is a functional food with antioxidant and anti-inflammatory properties. Recent studies also report its beneficial metabolic effects in a context of obesity or diabetes, although the mechanisms involved are poorly understood. The aim of this work was to analyze the effects of an ABG extract in the vascular and metabolic alterations induced by a high-fat/sucrose diet in rats. For this purpose, male Sprague-Dawley rats were fed either a standard chow (controls; n = 12) or a high-fat/sucrose diet (HFD; n = 24) for 16 weeks. From week 8 on, half of the HFD rats were treated with a commercial ABG extract concentrated in S-allyl cysteine and melanoidins (ABG10+(R); 250 mg/kg daily by gavage; 5 mL/kg). ABG10+(R)-treated rats showed lower mean caloric intake, body weight, triglycerides, low density lipoprotein cholesterol (LDL-c), insulin and leptin serum concentrations and higher high density lipoprotein cholesterol (HDL-c) and adiponectin serum concentrations than non-treated rats. In the hypothalamus, ABG10+(R) treatment induced an increase in the gene expression of proopiomelanocortin (POMC) and a decrease in leptin receptor (ObR) mRNA levels. No significant changes were found in visceral adipose tissue except for an overexpression of beta 3-adrenergic receptor (beta 3-ADR) in ABG-treated rats. In subcutaneous adipose tissue, ABG10+(R) treatment decreased adipose weight and downregulated the gene expression of PPAR-gamma, LPL, ObR and HSL. In brown adipose tissue, an overexpression of InsR, GLUT-4, UCP-1 and beta 3-ADR in ABG10+(R)-treated rats was found, whereas PPAR-gamma mRNA levels were significantly decreased. Regarding vascular function, ABG10+(R) treatment attenuated the obesity-induced vasoconstriction in response to potassium chloride both in presence/absence of perivascular adipose tissue (PVAT). On the contrary, aorta segments from ABG-treated rats showed and improved relaxation in response to acetylcholine only when PVAT was present, with this fact possible being related to the decreased gene expression of proinflammatory cytokines in this tissue. In conclusion, ABG10+(R) administration partially improves the metabolic and vascular alterations induced by a high-fat/high-sucrose diet in rats through modifications in the gene expression of proteins and neuropeptides involved in inflammation, fat metabolism and food intake regulation. Further studies are required to assess the bioavailability of ABG between rats and humans.
C1 [Amor, Sara; Gonzalez-Hedstrom, Daniel; Martin-Carro, Beatriz; Luis Garcia-Villalon, Angel; Granado, Miriam] Univ Autonoma Madrid, Fac Med, Dept Fisiol, C Arzobispo Morcillo 2, Madrid 28029, Spain.
   [Gonzalez-Hedstrom, Daniel; Manuel Inarejos-Garcia, Antonio; Almodovar, Paula] Pharmact Biotech Prod SL, Parque Cient Madrid, Madrid 28049, Spain.
   [Prodanov, Marin] Univ Autonoma Madrid, Fac Ciencias, Dept Quim Fis Aplicada, CIAL,CEI,CSIC, E-28049 Madrid, Spain.
   [Granado, Miriam] Inst Salud Carlos III, CIBER Fisiopatol Obes & Nutr, Madrid 28029, Spain.
C3 Autonomous University of Madrid; Consejo Superior de Investigaciones
   Cientificas (CSIC); CSIC-UAM - Instituto de Investigacion en Ciencias de
   la Alimentacion (CIAL); Autonomous University of Madrid; Instituto de
   Salud Carlos III; CIBER - Centro de Investigacion Biomedica en Red;
   CIBEROBN
RP Granado, M (corresponding author), Univ Autonoma Madrid, Fac Med, Dept Fisiol, C Arzobispo Morcillo 2, Madrid 28029, Spain.; Granado, M (corresponding author), Inst Salud Carlos III, CIBER Fisiopatol Obes & Nutr, Madrid 28029, Spain.
EM sara.amor@uam.es; dgonzalez@pharmactive.eu; beatriz.martinc@uam.es;
   aminarejos@pharmactive.eu; palmodovar@pharmactive.eu;
   marin.prodanov@uam.es; angeluis.villalon@uam.es; miriam.granado@uam.es
RI Garcia-Villalon, Angel/AAA-3067-2019; Granado, Miriam/B-8978-2017;
   Martin Carro, Beatriz/F-1481-2018
OI INAREJOS GARCIA, ANTONIO MANUEL/0000-0002-4869-6188; Granado,
   Miriam/0000-0001-9178-8822; Martin Carro, Beatriz/0000-0002-1683-6617;
   Gonzalez-Hedstrom, Daniel/0000-0001-9425-1115
FU Pharmactive Biotech Products S.L.
FX This study has been funded by Pharmactive Biotech Products S.L.
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NR 55
TC 41
Z9 43
U1 1
U2 23
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JAN
PY 2019
VL 11
IS 1
AR 153
DI 10.3390/nu11010153
PG 18
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA HJ8VI
UT WOS:000457477800030
PM 30642033
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Neuman, MG
   French, SW
   French, BA
   Seitz, HK
   Cohen, LB
   Mueller, S
   Osna, NA
   Kharbanda, KK
   Seth, D
   Bautista, A
   Thompson, KJ
   McKillop, IH
   Kirpich, IA
   McClain, CJ
   Bataller, R
   Nanau, RM
   Voiculescu, M
   Opris, M
   Shen, H
   Tillman, B
   Li, J
   Liu, H
   Thomes, PG
   Ganesan, M
   Malnick, S
AF Neuman, Manuela G.
   French, Samuel W.
   French, Barbara A.
   Seitz, Helmut K.
   Cohen, Lawrence B.
   Mueller, Sebastian
   Osna, Natalia A.
   Kharbanda, Kusum K.
   Seth, Devanshi
   Bautista, Abraham
   Thompson, Kyle J.
   McKillop, Iain H.
   Kirpich, Irina A.
   McClain, Craig J.
   Bataller, Ramon
   Nanau, Radu M.
   Voiculescu, Mihai
   Opris, Mihai
   Shen, Hong
   Tillman, Brittany
   Li, Jun
   Liu, Hui
   Thomes, Paul G.
   Ganesan, Murali
   Malnick, Steve
TI Alcoholic and non-alcoholic steatohepatitis
SO EXPERIMENTAL AND MOLECULAR PATHOLOGY
LA English
DT Review
DE Alcoholic hepatitis; Nonalcoholic steatohepatitis; Alcoholic liver
   disease; CYP2E1; Hangover; Hepatocarcinogenesis; Immunohistochemistry;
   Laboratory markers; Mallory-Denk bodies; Methylation; Mitochondrion;
   Micronutrients; Viral hepatitis; Human immunodeficiency virus
ID FATTY LIVER-DISEASE; CARBOHYDRATE-DEFICIENT TRANSFERRIN; HEPATOCYTE
   NUCLEAR FACTOR-4-ALPHA; GAMMA-GLUTAMYL-TRANSFERASE; INDUCED OXIDATIVE
   STRESS; HEPATOCELLULAR-CARCINOMA; HEPATITIS-C; SCORING SYSTEM;
   DIETARY-FAT; MOUSE MODEL
AB This paper is based upon the "Charles Lieber Satellite Symposia" organized by Manuela G. Neuman at the Research Society on Alcoholism (RSA) Annual Meetings, 2013 and 2014. The present review includes pre-clinical, translational and clinical research that characterize alcoholic liver disease (ALD) and non-alcoholic steatohepatitis (NASH). In addition, a literature search in the discussed area was performed.
   Strong clinical and experimental evidence lead to recognition of the key toxic role of alcohol in the pathogenesis of ALD. The liver biopsy can confirm the etiology of NASH or alcoholic steatohepatitis (ASH) and assess structural alterations of cells, their organelles, as well as inflammatory activity. Three histological stages of ALD are simple steatosis, ASH, and chronic hepatitis with hepatic fibrosis or cirrhosis. These latter stages may also be associated with a number of cellular and histological changes, including the presence of Mallory's hyaline, megamitochondria, or perivenular and perisinusoidal fibrosis. Genetic polymorphisms of ethanol metabolizing enzymes such as cytochrome p450 (CYP) 2E1 activation may change the severity of ASH and NASH. Alcohol mediated hepatocarcinogenesis, immune response to alcohol in ASH, as well as the role of other risk factors such as its co-morbidities with chronic viral hepatitis in the presence or absence of human immunodeficiency virus are discussed. Dysregulation of hepatic methylation, as result of ethanol exposure, in hepatocytes transfected with hepatitis C virus (HCV), illustrates an impaired interferon signaling. The hepatotoxic effects of ethanol undermine the contribution of malnutrition to the liver injury. Dietary interventions such as micro and macronutrients, as well as changes to the microbiota are suggested. The clinical aspects of NASH, as part of metabolic syndrome in the aging population, are offered.
   The integrative symposia investigate different aspects of alcohol-induced liver damage and possible repair. We aim to (1) determine the immuno-pathology of alcohol-induced liver damage, (2) examine the role of genetics in the development of ASH, (3) propose diagnostic markers of ASH and NASH, (4) examine age differences, (5) develop common research tools to study alcohol-induced effects in clinical and pre-clinical studies, and (6) focus on factors that aggravate severity of organ-damage. The intention of these symposia is to advance the international profile of the biological research on alcoholism. We also wish to further our mission of leading the forum to progress the science and practice of translational research in alcoholism. (C) 2014 Elsevier Inc. All rights reserved.
C1 [Neuman, Manuela G.; Nanau, Radu M.; Opris, Mihai] Univ Toronto, Toronto, ON M5G 0A3, Canada.
   [Neuman, Manuela G.] Univ Toronto, Fac Med, Dept Pharmacol & Toxicol, Toronto, ON M5G 0A3, Canada.
   [French, Samuel W.; French, Barbara A.; Shen, Hong; Tillman, Brittany; Li, Jun; Liu, Hui] Harbor UCLA Med Ctr, Torrance, CA 90509 USA.
   [Seitz, Helmut K.; Mueller, Sebastian] Heidelberg Univ, Alcohol Res Ctr, Heidelberg, Germany.
   [Seitz, Helmut K.; Mueller, Sebastian] Salem Med Ctr, Dept Med Gastroenterol & Hepatol, Heidelberg, Germany.
   [Cohen, Lawrence B.] Univ Toronto, Fac Med, Sunnybrook Hlth Sci Ctr, Dept Med,Div Gastroenterol, Toronto, ON M5G 0A3, Canada.
   [Osna, Natalia A.; Kharbanda, Kusum K.; Thomes, Paul G.; Ganesan, Murali] Univ Nebraska, Med Ctr, Vet Affairs Nebraska Western Iowa Hlth Care Syst, Res Serv, Omaha, NE 68182 USA.
   [Seth, Devanshi] Royal Prince Alfred Hosp, Centenary Inst Canc Med & Cell Biol, Drug Hlth Serv, Camperdown, NSW 2050, Australia.
   [Seth, Devanshi] Univ Sydney, Fac Med, Sydney, NSW 2006, Australia.
   [Bautista, Abraham] NIAAA, Off Extramural Activ, NIH, Rockville, MD 20852 USA.
   [Thompson, Kyle J.; McKillop, Iain H.] NIAAA, Off Extramural Activ, NIH, Rockville, MD 20852 USA.
   [McClain, Craig J.] Univ Louisville, Sch Med, Louisville, KY 40292 USA.
   [Bataller, Ramon] Robley Rex Vet Med Ctr, Louisville, KY USA.
   [Bataller, Ramon] Univ N Carolina, Dept Med, Div Gastroenterol & Hepatol, Chapel Hill, NC USA.
   [Malnick, Steve] Univ N Carolina, Dept Nutr, Chapel Hill, NC USA.
   [Malnick, Steve] Kaplan Med Ctr, Dept Internal Med, Rehovot, Israel.
   [Voiculescu, Mihai] Hebrew Univ Jerusalem, IL-76100 Rehovot, Israel.
   [Opris, Mihai] Fundeni Clin Inst, Div Nephrol & Internal Med, Bucharest, Romania.
   [Opris, Mihai] Univ Med & Pharm Carol Davila, Bucharest, Romania.
   [Opris, Mihai] Family Med Clin CAR, Bucharest, Romania.
C3 University of Toronto; University of Toronto; University of California
   System; University of California Los Angeles; University of California
   Los Angeles Medical Center; Ruprecht Karls University Heidelberg;
   University of Toronto; Sunnybrook Health Science Center; Sunnybrook
   Research Institute; US Department of Veterans Affairs; Veterans Health
   Administration (VHA); VA Nebraska-Western Iowa Health Care System;
   University of Nebraska System; University of Nebraska Medical Center;
   NSW Health; Royal Prince Alfred Hospital; University of Sydney;
   Centenary Institute; University of Sydney; National Institutes of Health
   (NIH) - USA; NIH National Institute on Alcohol Abuse & Alcoholism
   (NIAAA); National Institutes of Health (NIH) - USA; NIH National
   Institute on Alcohol Abuse & Alcoholism (NIAAA); University of
   Louisville; University of North Carolina; University of North Carolina
   Chapel Hill; University of North Carolina; University of North Carolina
   Chapel Hill; Hebrew University of Jerusalem; Kaplan Medical Center;
   Hebrew University of Jerusalem; Institutul Clinic Fundeni; Carol Davila
   University of Medicine & Pharmacy
RP Neuman, MG (corresponding author), Univ Toronto, Fac Med, Vitro Drug Safety & Biotechnol Banting Inst, Dept Pharmacol & Toxicol, 100 Coll St,Lab 217, Toronto, ON M5G 0A3, Canada.
EM manuela.neuman@utoronto.ca
OI Bataller, Ramon/0000-0002-1119-7799
FU NIH [AAUOI-021848-02, P50-11999]; Merit Review grants from the
   Department of Veterans Affairs, Office of Research and Development
   (Biomedical Laboratory and Development) [BX001673, BX001155]; In Vitro
   Drug Safety and Biotechnology; Mahaffy Grant, Sunnybrook HSC
FX S. French and his team thank Adriana Flores for typing the manuscript
   and thank NIH for the grant support (AAUOI-021848-02 and P50-11999
   Morphology Core).Drs. Osna and Kharbanda acknowledge that their research
   reported here was supported by Merit Review grants BX001673 (NAO) and
   BX001155 (KKK) from the Department of Veterans Affairs, Office of
   Research and Development (Biomedical Laboratory and Development).Drs.
   Neuman and Cohen thank In Vitro Drug Safety and Biotechnology and
   Mahaffy Grant, Sunnybrook HSC for the funding.
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NR 243
TC 49
Z9 55
U1 1
U2 50
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0014-4800
EI 1096-0945
J9 EXP MOL PATHOL
JI Exp. Mol. Pathol.
PD DEC
PY 2014
VL 97
IS 3
BP 492
EP 510
DI 10.1016/j.yexmp.2014.09.005
PG 19
WC Pathology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pathology
GA AX1CK
UT WOS:000346685700024
PM 25217800
OA Green Submitted, Green Accepted
DA 2025-06-11
ER

PT J
AU Bahrami, P
   Aromolaran, KA
   Aromolaran, AS
AF Bahrami, Pegah
   Aromolaran, Kelly A.
   Aromolaran, Ademuyiwa S.
TI Mechanistic Relevance of Ventricular Arrhythmias in Heart Failure with
   Preserved Ejection Fraction
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE obesity; diabetes; heart failure; sudden cardiac death; ventricular;
   arrhythmias; ion channel remodeling
ID LATE SODIUM CURRENT; LEUKOTRIENE B-4; OXIDATIVE STRESS; DIASTOLIC
   DYSFUNCTION; ANGIOTENSIN-II; DELAYED AFTERDEPOLARIZATIONS; MYOCARDIAL
   DYSFUNCTION; INSULIN-RESISTANCE; POTASSIUM CURRENTS; CHANNEL CURRENT
AB Heart failure with preserved ejection fraction (HFpEF) is increasing at an alarming rate worldwide, with limited effective therapeutic interventions in patients. Sudden cardiac death (SCD) and ventricular arrhythmias present substantial risks for the prognosis of these patients. Obesity is a risk factor for HFpEF and life-threatening arrhythmias. Obesity and its associated metabolic dysregulation, leading to metabolic syndrome, are an epidemic that poses a significant public health problem. More than one-third of the world population is overweight or obese, leading to an enhanced risk of incidence and mortality due to cardiovascular disease (CVD). Obesity predisposes patients to atrial fibrillation and ventricular and supraventricular arrhythmias-conditions that are caused by dysfunction in the electrical activity of the heart. To date, current therapeutic options for the cardiomyopathy of obesity are limited, suggesting that there is considerable room for the development of therapeutic interventions with novel mechanisms of action that will help normalize sinus rhythms in obese patients. Emerging candidates for modulation by obesity are cardiac ion channels and Ca-handling proteins. However, the underlying molecular mechanisms of the impact of obesity on these channels and Ca-handling proteins remain incompletely understood. Obesity is marked by the accumulation of adipose tissue, which is associated with a variety of adverse adaptations, including dyslipidemia (or abnormal systemic levels of free fatty acids), increased secretion of proinflammatory cytokines, fibrosis, hyperglycemia, and insulin resistance, which cause electrical remodeling and, thus, predispose patients to arrhythmias. Furthermore, adipose tissue is also associated with the accumulation of subcutaneous and visceral fat, which is marked by distinct signaling mechanisms. Thus, there may also be functional differences in the effects of the regional distribution of fat deposits on ion channel/Ca-handling protein expression. Evaluating alterations in their functional expression in obesity will lead to progress in the knowledge of the mechanisms responsible for obesity-related arrhythmias. These advances are likely to reveal new targets for pharmacological modulation. Understanding how obesity and related mechanisms lead to cardiac electrical remodeling is likely to have a significant medical and economic impact. Nevertheless, substantial knowledge gaps remain regarding HFpEF treatment, requiring further investigations to identify potential therapeutic targets. The objective of this study is to review cardiac ion channel/Ca-handling protein remodeling in the predisposition to metabolic HFpEF and arrhythmias. This review further highlights interleukin-6 (IL-6) as a potential target, cardiac bridging integrator 1 (cBIN1) as a promising gene therapy agent, and leukotriene B4 (LTB4) as an underappreciated pathway in future HFpEF management.
C1 [Bahrami, Pegah; Aromolaran, Kelly A.; Aromolaran, Ademuyiwa S.] Univ Utah, Sch Med, Nora Eccles Harrison Cardiovasc Res & Training Ins, 95 S 2000 E, Salt Lake City, UT 84112 USA.
   [Aromolaran, Ademuyiwa S.] Univ Utah, Dept Surg, Biochem & Mol Med Program, Sch Med,Div Cardiothorac Surg Nutr & Integrat Phys, Salt Lake City, UT 84112 USA.
C3 Utah System of Higher Education; University of Utah; Utah System of
   Higher Education; University of Utah
RP Aromolaran, AS (corresponding author), Univ Utah, Sch Med, Nora Eccles Harrison Cardiovasc Res & Training Ins, 95 S 2000 E, Salt Lake City, UT 84112 USA.; Aromolaran, AS (corresponding author), Univ Utah, Dept Surg, Biochem & Mol Med Program, Sch Med,Div Cardiothorac Surg Nutr & Integrat Phys, Salt Lake City, UT 84112 USA.
EM u6061560@utah.edu; kelly.aromolaran@utah.edu;
   ademuyiwa.aromolaran@hsc.utah.edu
RI Aromolaran, Ademuyiwa/AAF-5555-2019; Bahrami, Pegah/IZP-6822-2023
FU Nora Eccles Harrison Treadwell Foundation; NIH [R01 HL147044-01, R01
   HL174450-01]
FX This study was supported by the Nora Eccles Harrison Treadwell
   Foundation and the NIH (R01 HL147044-01; R01 HL174450-01 to A.S.A.).
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NR 236
TC 0
Z9 0
U1 2
U2 2
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD DEC
PY 2024
VL 25
IS 24
AR 13423
DI 10.3390/ijms252413423
PG 29
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA Q5E1W
UT WOS:001384902200001
PM 39769189
OA gold
DA 2025-06-11
ER

PT J
AU Chen, SS
   Zong, G
   Wu, QQ
   Yun, H
   Niu, ZH
   Zheng, H
   Zeng, R
   Sun, L
   Lin, X
AF Chen, Shuangshuang
   Zong, Geng
   Wu, Qingqing
   Yun, Huan
   Niu, Zhenhua
   Zheng, He
   Zeng, Rong
   Sun, Liang
   Lin, Xu
TI Associations of plasma glycerophospholipid profile with modifiable
   lifestyles and incident diabetes in middle-aged and older Chinese
SO DIABETOLOGIA
LA English
DT Article
DE Asian; Biomarker; Carbohydrate; Diabetes; Diet; Glycerophospholipid;
   Physical activity; Prospective study
ID ENDOPLASMIC-RETICULUM STRESS; N-3 FATTY-ACIDS; METABOLIC SYNDROME;
   INSULIN-RESISTANCE; DIET; PHOSPHATIDYLETHANOLAMINE; EXERCISE; RISK;
   MICE; PHOSPHATIDYLCHOLINE
AB Aims/hypothesis Glycerophospholipid (GPL) perturbance was linked to the pathogenesis of diabetes in animal studies but prospective studies in humans are rare, particularly in Asians. We aimed to investigate the associations between plasma GPLs and incident diabetes and to explore effects of lifestyle on the associations in a Chinese population.
   Methods The study included 1877 community-dwelling Chinese individuals aged 50-70 years (751 men and 1126 women), free of diabetes at baseline and followed for 6 years. A total of 160 GPL species were quantified in plasma at baseline by using high-throughput targeted lipidomics. Log-Poisson regression was used to assess the associations between GPLs and incidence of diabetes.
   Results Over the 6 years of follow-up, 499 participants (26.6%) developed diabetes. After multivariable adjustment, eight GPLs were positively associated with incident diabetes (RRper SD 1.13-1.25; all false-discovery rate [FDR]-corrected p < 0.05), including five novel GLPs, namely phosphatidylcholines (PCs; 16:0/18:1, 18:0/16:1, 18:1/20:3), lysophosphatidylcholine (LPC; 20:3) and phosphatidylethanolamine (PE; 16:0/16:1), and three reported GPLs (PCs 16:0/16:1, 16:0/20:3 and 18:0/20:3). In network analysis, a PC-containing module was positively associated with incident diabetes (RRper SD 1.16 [95% CI 1.06, 1.26]; FDR-corrected p < 0.05). Notably, three of the diabetes-associated PCs (16:0/16:1, 16:0/18:1 and 18:0/16:1) and PE (16:0/16:1) were associated not only with fatty acids in the de novo lipogenesis (DNL) pathway, especially 16:1n-7 (Spearman correlation coefficients = 0.35-0.62, p < 0.001), but also with an unhealthy dietary pattern high in refined grains and low in fish, dairy and soy products (|factor loadings| >= 0.2). When stratified by physical activity levels, the associations of the eight GPLs and the PC module with incident diabetes were stronger in participants with lower physical activity (RRper SD 1.24-1.49, FDR-corrected p < 0.05) than in those with the median and higher physical activity levels (RRper SD 1.03-1.12, FDR-corrected p >= 0.05; FDR-corrected p(interaction) < 0.05).
   Conclusions/interpretation Eight GPLs, especially PCs associated with the DNL pathway, were positively associated with incident diabetes in a cohort of Chinese men and women. The associations were most prominent in participants with a low level of physical activity.
C1 [Chen, Shuangshuang; Zong, Geng; Yun, Huan; Niu, Zhenhua; Zheng, He; Sun, Liang] Chinese Acad Sci, Univ Chinese Acad Sci, Shanghai Inst Nutr & Hlth, Shanghai, Peoples R China.
   [Wu, Qingqing; Zeng, Rong] Chinese Acad Sci, Ctr Excellence Mol Cell Sci, Shanghai Inst Biochem & Cell Biol, Shanghai, Peoples R China.
   [Zeng, Rong; Lin, Xu] Univ Chinese Acad Sci, Hangzhou Inst Adv Study, Key Lab Syst Hlth Sci Zhejiang Prov, Hangzhou, Peoples R China.
   [Lin, Xu] Chinese Acad Sci, Shanghai Inst Nutr & Hlth, Shanghai, Peoples R China.
C3 Chinese Academy of Sciences; University of Chinese Academy of Sciences,
   CAS; Shanghai Institute of Nutrition & Health, CAS; Chinese Academy of
   Sciences; Center for Excellence in Molecular Cell Science, CAS; Chinese
   Academy of Sciences; University of Chinese Academy of Sciences, CAS;
   Chinese Academy of Sciences; Shanghai Institute of Nutrition & Health,
   CAS
RP Sun, L (corresponding author), Chinese Acad Sci, Univ Chinese Acad Sci, Shanghai Inst Nutr & Hlth, Shanghai, Peoples R China.; Zeng, R (corresponding author), Chinese Acad Sci, Ctr Excellence Mol Cell Sci, Shanghai Inst Biochem & Cell Biol, Shanghai, Peoples R China.; Zeng, R; Lin, X (corresponding author), Univ Chinese Acad Sci, Hangzhou Inst Adv Study, Key Lab Syst Hlth Sci Zhejiang Prov, Hangzhou, Peoples R China.; Lin, X (corresponding author), Chinese Acad Sci, Shanghai Inst Nutr & Hlth, Shanghai, Peoples R China.
EM zr@sibs.ac.cn; sunliang@sibs.ac.cn; xlin@sibs.ac.cn
RI Zeng, Rong/P-2269-2017; Zong, Geng/ABG-6946-2021; lin, xu/KOC-3517-2024
OI Wu, Qingqing/0000-0001-8087-2420
FU Strategic Priority Research Program of the Chinese Academy of Sciences
   [XDB38000000]; Major Project of the Ministry of Science and Technology
   of China [2017YFC0909701, 2016YFC1304903]; National Natural Science
   Foundation of China [81700700, 81970684, 81561128018]; Chinese Academy
   of Sciences [ZDBS-SSW-DQC-02, KSCX2-EW-R10, KJZD-EW-L14-2-2]; Shanghai
   Municipal Science and Technology Major Project [2017SHZDZX01]
FX This study was supported by the Strategic Priority Research Program of
   the Chinese Academy of Sciences (XDB38000000), the Major Project of the
   Ministry of Science and Technology of China (2017YFC0909701,
   2016YFC1304903), the National Natural Science Foundation of China
   (81700700, 81970684, 81561128018), the Chinese Academy of Sciences
   (ZDBS-SSW-DQC-02, KSCX2-EW-R10, KJZD-EW-L14-2-2) and the Shanghai
   Municipal Science and Technology Major Project (2017SHZDZX01).
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NR 48
TC 41
Z9 44
U1 1
U2 32
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0012-186X
EI 1432-0428
J9 DIABETOLOGIA
JI Diabetologia
PD FEB
PY 2022
VL 65
IS 2
BP 315
EP 328
DI 10.1007/s00125-021-05611-3
EA NOV 2021
PG 14
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA YD3GA
UT WOS:000720704500002
PM 34800146
OA Bronze
DA 2025-06-11
ER

PT J
AU Yan, Z
   Luo, J
   Wang, Y
   Yang, J
   Su, ML
   Jiang, L
   Yang, JL
   Dai, MY
   Liu, AM
AF Yan, Zheng
   Luo, Jia
   Wang, Ying
   Yang, Jie
   Su, Mingli
   Jiang, Lei
   Yang, Julin
   Dai, Manyun
   Liu, Aiming
TI PPARα suppresses low-intensity-noise-induced body weight gain in mice:
   the activated HPA axis plays an critical role
SO INTERNATIONAL JOURNAL OF OBESITY
LA English
DT Article
ID INDUCED HEARING-LOSS; METABOLIC SYNDROME; HEPATIC STEATOSIS; MODEL;
   EXPOSURE; STRESS
AB BackgroundAs the second most risky environmental pollution, noise imposes threats to human health. Exposure to high-intensity noise causes hearing impairment, psychotic disorders, endocrine modifications. The relationship among low-intensity noise, obesity and lipid-regulating nuclear factor PPAR alpha is not yet clear.MethodsIn this study, male wild-type (WT) and Ppar alpha-null (KO) mice on a high-fat diet (HFD) were exposed to 75 dB noise for 12 weeks to explore the effect of low-intensity noise on obesity development and the role of PPAR alpha. 3T3-L1 cells were treated with dexamethasone (DEX) and sodium oleate (OA) to verify the down-stream effect of hypothalamic-pituitary-adrenal (HPA) axis activation on the adipose tissues.ResultsThe average body weight gain (BWG) of WT mice on HFD exposed to noise was inhibited, which was not observed in KO mice. The mass and adipocyte size of adipose tissues accounted for the above difference of BWG tendency. In WT mice on HFD, the adrenocorticotropic hormone level was increased by the noise challenge. The aggravation of fatty liver by noise exposure occurred in both mouse lines, and the transport of hepatic redundant lipid to adipose tissues were similar. The lipid metabolism in adipose tissue driven by HPA axis accorded with the BWG inhibition in vivo, validated in 3T3-L1 adipogenic stem cells.ConclusionChronic exposure to low-intensity noise aggravated fatty liver in both WT and KO mice. BWG inhibition was observed only in WT mice, which covered up the aggravation of fatty liver by noise exposure. PPAR alpha mediates the activation of HPA axis by noise exposure in mice on HFD. Elevated adrenocorticotropic hormone (ACTH) promoted lipid metabolism in adipocytes, which contributed to the disassociation of BWG and fatty liver development in male WT mice.Summary of PPAR alpha suppresses noise-induced body weight gain in mice on high-fat-diet. Chronic exposure to low-intensity noise exposure inhibited BWG by PPAR alpha-dependent activation of the HPA axis.ConclusionChronic exposure to low-intensity noise aggravated fatty liver in both WT and KO mice. BWG inhibition was observed only in WT mice, which covered up the aggravation of fatty liver by noise exposure. PPAR alpha mediates the activation of HPA axis by noise exposure in mice on HFD. Elevated adrenocorticotropic hormone (ACTH) promoted lipid metabolism in adipocytes, which contributed to the disassociation of BWG and fatty liver development in male WT mice.Summary of PPAR alpha suppresses noise-induced body weight gain in mice on high-fat-diet. Chronic exposure to low-intensity noise exposure inhibited BWG by PPAR alpha-dependent activation of the HPA axis.
C1 [Yan, Zheng; Luo, Jia; Wang, Ying; Yang, Jie; Su, Mingli; Jiang, Lei; Dai, Manyun; Liu, Aiming] Ningbo Univ, Hlth Sci Ctr, Ningbo 315211, Peoples R China.
   [Yang, Julin] Ningbo Coll Hlth Sci, Dept Basic Nutr, Ningbo 315211, Peoples R China.
C3 Ningbo University
RP Dai, MY; Liu, AM (corresponding author), Ningbo Univ, Hlth Sci Ctr, Ningbo 315211, Peoples R China.
EM daimanyun@nbu.edu.cn; liuaiming@nbu.edu.cn
RI Dai, Manyun/GZB-0789-2022
FU NCI NIH
FX Dr. Frank J Gonzalez at NCI NIH was greatly appreciated for gift of PPAR
   alpha transgenic mice. The authors thank the technical support group at
   the core facility platform of Ningbo University School of Medicine. The
   Graphical Abstract was partly generated using Servier Medical Art,
   provided by Servier, licensed under a Creative Commons Attribution 3.0
   Unported License.
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NR 45
TC 0
Z9 0
U1 2
U2 6
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0307-0565
EI 1476-5497
J9 INT J OBESITY
JI Int. J. Obes.
PD SEP
PY 2024
VL 48
IS 9
BP 1274
EP 1282
DI 10.1038/s41366-024-01550-2
EA JUN 2024
PG 9
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA D8U0B
UT WOS:001252101300001
PM 38902386
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Khalili-Moghadam, S
   Hedayati, M
   Golzarand, M
   Mirmiran, P
AF Khalili-Moghadam, Sajad
   Hedayati, Mehdi
   Golzarand, Mahdieh
   Mirmiran, Parvin
TI Effects of green coffee aqueous extract supplementation on glycemic
   indices, lipid profile, CRP, and malondialdehyde in patients with type 2
   diabetes: a randomized, double-blind, placebo-controlled trial
SO FRONTIERS IN NUTRITION
LA English
DT Article
DE type 2 diabetes; Hs-CRP; Malondialdehyde; Insulin; lipid profile; green
   coffee
ID INSULIN-RESISTANCE; METABOLIC SYNDROME; MODEL ASSESSMENT; GLUCOSE;
   METAANALYSIS; FAT; DIETARY
AB Background/objectivesStudies have reported the health benefits of green coffee extract (GCE) in experimental models. In the current study, we aimed to determine whether supplementation with GCE improves glycemic indices, inflammation, and oxidative stress in patients with type 2 diabetes (T2D).Methods and study designThis randomized, double-blind, placebo-controlled trial included 44 patients (26 male and 18 female) with T2D and overweight/obesity. After blocked randomization, patients received either capsules containing 400 mg GCE twice per day (n = 22) or a placebo (n = 22) and were followed for 10 weeks. In this study, glycemic indices, lipid profiles, anthropometric examinations, blood pressure, high-sensitivity C-reactive protein (hs-CRP), and malondialdehyde (MDA) were measured twice; at baseline and at the end of the study.ResultsAfter 10 weeks of supplementation, GCE supplementation significantly reduced body weight (p = 0.04) and body mass index (BMI) (p = 0.03) compared to the placebo. The intention-to-treat (ITT) analysis indicated patients in the GCE group had a lower fasting blood glucose (FBG) concentration compared to the placebo group; however, this decreasing was marginally significant (8.48 +/- 8.41 vs. 1.70 +/- 5.82 mg/dL, p = 0.05). There was no significant difference in insulin levels and HOMA-IR between the groups. At the end of the study, significant changes in systolic blood pressure (SBP) (p = 0.01), triglyceride (TG) level (p = 0.02), high-density lipoprotein (HDL) (p = 0.001), and TG-to-HDL ratio (p = 0.001) were found between the intervention and placebo groups. Our trial indicated GCE supplementation had no effect on diastolic blood pressure (DBP), low-density lipoprotein (LDL), or total cholesterol. During the supplementation period, the hs-CRP level significantly decreased in the GCE group compared to the placebo group (p = 0.02). No significant changes were observed in the MDA level between the two groups at the end of the study (p = 0.54).ConclusionOur findings showed beneficial effects of GCE on SBP, TG, hs-CRP, and HDL levels in patients with T2D and overweight/obesity over a 10-week period of supplementation.Clinical trial registration:https://en.irct.ir/trial/48549, identifier [IRCT20090203001640N18].ConclusionOur findings showed beneficial effects of GCE on SBP, TG, hs-CRP, and HDL levels in patients with T2D and overweight/obesity over a 10-week period of supplementation.Clinical trial registration:https://en.irct.ir/trial/48549, identifier [IRCT20090203001640N18].
C1 [Khalili-Moghadam, Sajad; Mirmiran, Parvin] Shahid Beheshti Univ Med Sci, Natl Nutr & Food Technol Res Inst, Fac Nutr & Food Technol, Dept Clin Nutr & Dietet, Tehran, Iran.
   [Hedayati, Mehdi] Shahid Beheshti Univ Med Sci, Res Inst Endocrine Sci, Cellular & Mol Endocrine Res Ctr, Tehran, Iran.
   [Golzarand, Mahdieh; Mirmiran, Parvin] Shahid Beheshti Univ Med Sci, Res Inst Endocrine Sci, Nutr & Endocrine Res Ctr, Tehran, Iran.
C3 Shahid Beheshti University Medical Sciences; Shahid Beheshti University
   Medical Sciences; Shahid Beheshti University Medical Sciences
RP Mirmiran, P (corresponding author), Shahid Beheshti Univ Med Sci, Natl Nutr & Food Technol Res Inst, Fac Nutr & Food Technol, Dept Clin Nutr & Dietet, Tehran, Iran.; Golzarand, M; Mirmiran, P (corresponding author), Shahid Beheshti Univ Med Sci, Res Inst Endocrine Sci, Nutr & Endocrine Res Ctr, Tehran, Iran.
EM mahdieh_golzarand@yahoo.com; mirmiran@endocrine.ac.ir
RI Hedayati, Mehdi/AAG-3006-2019; Mirmiran, Parvin/V-1433-2019
OI khalili moghadam, sajad/0000-0002-3722-5153
FU National Nutrition and Food Technology Research Institute, Shahid
   Beheshti University of Medical Sciences; National Nutrition and Food
   Technology Research Institute, Shahid Beheshti University of Medical
   Sciences, Tehran, Iran; Research Institute for Endocrine Science, Shahid
   Beheshti University of Medical Sciences
FX The authors gratefully wish to thank the National Nutrition and Food
   Technology Research Institute, Shahid Beheshti University of Medical
   Sciences, Tehran, Iran, for their study funding and financial support.
   We thank the laboratory section of the Research Institute for Endocrine
   Science, Shahid Beheshti University of Medical Sciences. We also thank
   all the patients who participated in the study.
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NR 37
TC 5
Z9 5
U1 0
U2 6
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD NOV 16
PY 2023
VL 10
AR 1241844
DI 10.3389/fnut.2023.1241844
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA Z2PJ1
UT WOS:001110544700001
PM 38035358
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Kim, IH
   Choi, JW
   Lee, MK
   Kwon, CJ
   Nam, TJ
AF Kim, In-Hye
   Choi, Jung-Wook
   Lee, Min-Kyeong
   Kwon, Chang-Ju
   Nam, Taek-Jeong
TI Anti-obesity effects of pectinase and cellulase enzyme-treated
   Ecklonia cava extract in high-fat diet-fed C57BL/6N mice
SO INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
LA English
DT Article
DE anti-obesity; C57BL/6N mice; Ecklonia cava; rapidase X-Press L; Rohament
   CL; acetyl-CoA carboxylase; glucose transporter type 4
ID INDUCED CELL-DAMAGE; EDIBLE BROWN-ALGAE; NF-KAPPA-B; METABOLIC SYNDROME;
   CARDIOVASCULAR-DISEASE; LIVER-DISEASE; INSULIN-RESISTANCE; OXIDATIVE
   STRESS; ANTIOXIDANT PROPERTIES; BIOLOGICAL-ACTIVITIES
AB The present study investigated the anti-obesity effects of enzyme-treated Ecklonia cava extract (EEc) in C57BL/6N mice with high-fat diet (HFD)-induced obesity. The EEc was separated and purified with the digestive enzymes pectinase (Rapidase X-Press L) and cellulase (Rohament CL) and its effects on the progression of HFD-induced obesity were examined over 10 weeks. The mice were divided into 6 groups (n=10/group) as follows: Normal diet group, HFD group, mice fed a HFD with 25 mg/kg/day Garcinia cambogia extract and mice fed a HFD with 5, 25 or 150 mg/kg/day EEc (EHD groups). Changes in body weight, fat, serum lipid levels and lipogenic enzyme levels were determined. The body weight and liver weight were increased in the HFD group compared with those in the ND group, which was significantly reduced by EEc supplementation. In addition, significant reductions in epididymal, perirenal and mesenteric white adipose tissues were present in the EHD groups and all three EHD groups exhibited decreases in insulin, leptin and glutamate pyruvate transaminase levels compared with those in the HFD group. In addition, EEc treatment significantly decreased the serum and hepatic triglyceride levels compared with those in the HFD group. However, the levels of high-density lipoprotein cholesterol/total cholesterol ration increased significantly in EHD-25 and -150 groups compared with those in the HFD group. Changes in adipogenic and lipogenic protein expression in the liver was assessed by western blot analysis. The EHD-25 and -150 groups exhibited reduced levels of CCAAT/enhancer-binding protein and peroxisome proliferator activated receptor . However, the phosphorylation ratios of AMP-activated protein kinase and acetyl-CoA carboxylase were significantly increased in the liver tissue obtained from the EHD (5, -25 and -150 mg/kg/day) groups compared with those in the HFD group. EEc supplementation reduced levels of sterol regulatory element-binding protein-1c, adipose fatty acid-binding protein, fatty acid synthase and leptin, while it significantly increased glucose transporter type 4 and adiponectin protein levels in the liver tissues of all three EHD groups compared with those in the HFD group. Taken together, these results suggest that EEc exerts anti-obesity effects by reducing body weight and the serum and hepatic levels of obesity-associated factors. Thus, EEc supplementation reduces HFD-induced obesity in C57BL/6N mice and has the potential to prevent obesity and subsequent metabolic disorders.
C1 [Kim, In-Hye; Nam, Taek-Jeong] Pukyong Natl Univ, Inst Fisheries Sci, Cell Biol Lab, Busan 46041, South Korea.
   [Choi, Jung-Wook; Lee, Min-Kyeong; Nam, Taek-Jeong] Pukyong Natl Univ, Dept Food Sci & Nutr, 45 Yongso Ro, Busan 48513, South Korea.
   [Kwon, Chang-Ju] Ju Yeong NS Co Ltd, Chunchon 24232, Gangwon Do, South Korea.
C3 Pukyong National University; Pukyong National University
RP Nam, TJ (corresponding author), Pukyong Natl Univ, Dept Food Sci & Nutr, 45 Yongso Ro, Busan 48513, South Korea.
EM namtj@pknu.ac.kr
RI Kim, Eun/AAS-6706-2020
FU Fishery Commercialization Technology Development Program through iPET
   (Korea Institute of Planning and Evaluation for Technology in Food,
   Agriculture, Forestry and Fisheries) - Ministry of Oceans and Fisheries
   [111090-03-3-HD110]; Basic Science Research Program through the National
   Research Foundation of Korea - Ministry of Education [2012R1A6A1028677]
FX This study was supported by the Fishery Commercialization Technology
   Development Program through iPET (Korea Institute of Planning and
   Evaluation for Technology in Food, Agriculture, Forestry and Fisheries)
   funded by the Ministry of Oceans and Fisheries (grant no.
   111090-03-3-HD110). This study was also supported by the Basic Science
   Research Program through the National Research Foundation of Korea
   funded by the Ministry of Education (grant no. 2012R1A6A1028677).
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NR 83
TC 11
Z9 11
U1 0
U2 8
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1107-3756
EI 1791-244X
J9 INT J MOL MED
JI Int. J. Mol. Med.
PD FEB
PY 2018
VL 41
IS 2
BP 924
EP 934
DI 10.3892/ijmm.2017.3295
PG 11
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA FT5VV
UT WOS:000423222200036
PM 29207025
OA hybrid, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Atlantis, E
   Fahey, P
   Martin, S
   O'Loughlin, P
   Taylor, AW
   Adams, RJ
   Shi, ZM
   Wittert, G
AF Atlantis, Evan
   Fahey, Paul
   Martin, Sean
   O'Loughlin, Peter
   Taylor, Anne W.
   Adams, Robert J.
   Shi, Zumin
   Wittert, Gary
TI Predictive value of serum testosterone for type 2 diabetes risk
   assessment in men
SO BMC ENDOCRINE DISORDERS
LA English
DT Article
DE Testosterone; Diabetes; Incidence; Screening; Prognosis; ROC; Cohort
ID LIFE-STYLE; INSULIN-RESISTANCE; METABOLIC SYNDROME; BODY-COMPOSITION;
   COHORT PROFILE; SYSTEMATIC ANALYSIS; GLUCOSE-TOLERANCE; GLYCEMIC
   CONTROL; ADIPOSE-TISSUE; HEART-FAILURE
AB Background: Effective prevention of type 2 diabetes (T2D) requires early identification of high-risk individuals who might benefit from intervention. We sought to determine whether low serum testosterone, a novel risk factor for T2D in men, adds clinically meaningful information beyond current T2D risk models.
   Methods: The Men Androgen Inflammation Lifestyle Environment and Stress (MAILES) study population consists of 2563 community-dwelling men aged 35-80 years in Adelaide, Australia. Of the MAILES participants, 2038 (80.0 %) provided information at baseline (2002-2006) and follow-up (2007-2010). After excluding participants with diabetes (n = 317), underweight (n = 5), and unknown BMI status (n = 11) at baseline; and unknown diabetes status (n = 50) at follow-up; 1655 participants were followed for 5 years. T2D at baseline and follow-up was defined by self-reported diabetes, or fasting plasma glucose (FPG) >= 7.0 mmol/L (126.1 mg/dL), or glycated haemoglobin (HbA1c) >= 6.5 %, or diabetes medications. Risk models were tested using logistic regression models. Sensitivity, specificity, positive predictive values (PPV) were used to identify the optimal cut-off point for low serum testosterone for incident T2D and the area under the receiver operating characteristic (AROC) curve was used to summarise the predictive power of the model. 15.5 % of men had at least one missing predictor variable; addressed through multiple imputation.
   Results: The incidence rate of T2D was 8.9 % (147/1655) over a median follow-up of 4.95 years (interquartile range: 4.35-5.00). Serum testosterone level predicted incident T2D (relative risk 0.96 [95 % CI: 0.92,1.00], P = 0.032) independent of current risk models including the AUSDRISK, but did not improve corresponding AROC statistics. A cut-off point of < 16 nmol/L for low serum testosterone, which classified about 43 % of men, returned equal sensitivity (61.3 % [95 % CI: 52.6,69.4]) and specificity (58.3 % [95 % CI: 55.6,60.9) for predicting T2D risk, with a PPV of 12.9 % (95 % CI: 10.4,15.8).
   Conclusions: Low serum testosterone predicts an increased risk of developing T2D in men over 5 years independent of current T2D risk models applicable for use in routine clinical practice. Screening for low serum testosterone in addition to risk factors from current T2D risk assessment models or tools, including the AUSDRISK, would identify a large subgroup of distinct men who might benefit from targeted preventive interventions.
C1 [Atlantis, Evan] Univ Western Sydney, Sch Nursing & Midwifery, Sydney, NSW, Australia.
   [Atlantis, Evan; Martin, Sean; Adams, Robert J.; Wittert, Gary] Univ Adelaide, Sch Med, Adelaide, SA, Australia.
   [Fahey, Paul] Univ Western Sydney, Sch Sci & Hlth, Sydney, NSW, Australia.
   [Martin, Sean] Univ Adelaide, Freemasons Fdn Ctr Mens Hlth, Adelaide, SA, Australia.
   [O'Loughlin, Peter] SA Pathology, Chem Pathol, Adelaide, SA, Australia.
   [Taylor, Anne W.; Shi, Zumin] Univ Adelaide, Populat Res & Outcome Studies, Adelaide, SA, Australia.
C3 Western Sydney University; University of Adelaide; Western Sydney
   University; University of Adelaide; SA Pathology; University of Adelaide
RP Atlantis, E (corresponding author), Univ Western Sydney, Sch Nursing & Midwifery, Sydney, NSW, Australia.; Atlantis, E (corresponding author), Univ Adelaide, Sch Med, Adelaide, SA, Australia.
EM e.atlantis@westernsydney.edu.au
RI Adams, Robert/Z-3197-2019; Atlantis, Evan/ABC-8075-2021; Shi,
   Zumin/A-1093-2009; Fahey, P/AGP-0614-2022; wittert, gary/AAE-2398-2019;
   Fahey, Paul/B-7985-2013; Taylor, Anne/F-5708-2010
OI Shi, Zumin/0000-0002-3099-3299; Atlantis, Evan/0000-0001-5877-6141;
   Fahey, Paul/0000-0002-6351-9876; O'Loughlin, Peter/0009-0002-0500-4433;
   Taylor, Anne/0000-0002-4422-7974; Wittert, Gary/0000-0001-6818-6065
FU National Health and Medical Research Council [627227]
FX This work was supported by the National Health and Medical Research
   Council [627227].
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NR 59
TC 36
Z9 38
U1 0
U2 8
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1472-6823
J9 BMC ENDOCR DISORD
JI BMC Endocr. Disord.
PD MAY 27
PY 2016
VL 16
AR 26
DI 10.1186/s12902-016-0109-7
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA DM9WL
UT WOS:000376716300001
PM 27230668
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Selvais, CM
   de Carrizosa, MADL
   Nachit, M
   Versele, R
   Dubuisson, N
   Noel, L
   Gillard, J
   Leclercq, IA
   Brichard, SM
   Abou-Samra, M
AF Selvais, Camille M. M.
   de Carrizosa, Maria A. Davis-Lopez
   Nachit, Maxime
   Versele, Romain
   Dubuisson, Nicolas
   Noel, Laurence
   Gillard, Justine
   Leclercq, Isabelle A. A.
   Brichard, Sonia M. M.
   Abou-Samra, Michel
TI AdipoRon enhances healthspan in middle-aged obese mice: striking
   alleviation of myosteatosis and muscle degenerative markers
SO JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
LA English
DT Article
DE adiponectin; myosteatosis; intramyocellular lipids; ageing; nonalcoholic
   fatty liver disease; endurance
ID INSULIN SENSITIVITY; CYLINDRICAL SPIRALS; OXIDATIVE STRESS; ADIPONECTIN;
   ACTIVATION; EXERCISE; AUTOPHAGY
AB BackgroundObesity among older adults has increased tremendously. Obesity accelerates ageing and predisposes to age-related conditions and diseases, such as loss of endurance capacity, insulin resistance and features of the metabolic syndrome. Namely, ectopic lipids play a key role in the development of nonalcoholic fatty liver disease (NAFLD) and myosteatosis, two severe burdens of ageing and metabolic diseases. Adiponectin (ApN) is a hormone, mainly secreted by adipocytes, which exerts insulin-sensitizing and fat-burning properties in several tissues including the liver and the muscle. Its overexpression also increases lifespan in mice. In this study, we investigated whether an ApN receptor agonist, AdipoRon (AR), could slow muscle dysfunction, myosteatosis and degenerative muscle markers in middle-aged obese mice. The effects on myosteatosis were compared with those on NAFLD. MethodsThree groups of mice were studied up to 62 weeks of age: One group received normal diet (ND), another, high-fat diet (HFD); and the last, HFD combined with AR given orally for almost 1 year. An additional group of young mice under an ND was used. Treadmill tests and micro-computed tomography (CT) were carried out in vivo. Histological, biochemical and molecular analyses were performed on tissues ex vivo. Bodipy staining was used to assess intramyocellular lipid (IMCL) and lipid droplet morphology. ResultsAR did not markedly alter diet-induced obesity. Yet, this treatment rescued exercise endurance in obese mice (up to 2.4-fold, P < 0.05), an event that preceded the improvement of insulin sensitivity. Dorsal muscles and liver densities, measured by CT, were reduced in obese mice (-42% and -109%, respectively, P < 0.0001), suggesting fatty infiltration. This reduction tended to be attenuated by AR. Accordingly, AR significantly mitigated steatosis and cellular ballooning at liver histology, thereby decreasing the NALFD activity score (-30%, P < 0.05). AR also strikingly reversed IMCL accumulation either due to ageing in oxidative fibres (types 1/2a, soleus) or to HFD in glycolytic ones (types 2x/2b, extensor digitorum longus) (-50% to -85%, P < 0.05 or less). Size of subsarcolemmal lipid droplets, known to be associated with adverse metabolic outcomes, was reduced as well. Alleviation of myosteatosis resulted from improved mitochondrial function and lipid oxidation. Meanwhile, AR halved aged-related accumulation of dysfunctional proteins identified as tubular aggregates and cylindrical spirals by electron microscopy (P < 0.05). ConclusionsLong-term AdipoRon treatment promotes 'healthy ageing' in obese middle-aged mice by enhancing endurance and protecting skeletal muscle and liver against the adverse metabolic and degenerative effects of ageing and caloric excess.
C1 [Selvais, Camille M. M.; de Carrizosa, Maria A. Davis-Lopez; Versele, Romain; Dubuisson, Nicolas; Noel, Laurence; Brichard, Sonia M. M.; Abou-Samra, Michel] UCLouvain, Inst Expt & Clin Res, Endocrinol Diabet & Nutr Unit, Brussels, Belgium.
   [de Carrizosa, Maria A. Davis-Lopez] Univ Seville, Fac Biol, Dept Physiol, Seville, Spain.
   [Nachit, Maxime; Gillard, Justine; Leclercq, Isabelle A. A.] UCLouvain, Inst Expt & Clin Res, Hepatogastroenterol Unit, Brussels, Belgium.
C3 Universite Catholique Louvain; University of Sevilla; Universite
   Catholique Louvain
RP Selvais, CM (corresponding author), UCLouvain, Inst Expt & Clin Res, Endocrinol Diabet & Nutr Unit, Brussels, Belgium.
EM camille.selvais@uclouvain.be
RI ; Davis Lopez de Carrizosa/F-9383-2015
OI ABOU-SAMRA, Michel/0000-0003-2312-7998; Nachit,
   Maxime/0000-0002-2333-9213; Davis Lopez de
   Carrizosa/0000-0002-2551-3115; Gillard, Justine/0000-0002-3372-8802
FU UCL University; Societe Francophone du Diabete/Roche Diabetes Care 2020;
   Fund for Scientific Research-FNRS; FRIA; Wallonie-Bruxelles
   International Excellence Program;  [35275437]
FX This work was supported by grants from UCL University (Research project
   FSR 2017), Societe Francophone du Diabete/Roche Diabetes Care 2020 and
   Fund for Scientific Research-FNRS (Research Credit 35275437, 2019). M.
   A. -S. is Charge de Recherches and C. M. S. has received a fellowship
   from the FRIA. M. A. D. -L. d. C. received a fellowship from the
   Wallonie-Bruxelles International Excellence Program. We are grateful to
   Caroline Bouzin and the IREC imaging platform for the use of the
   equipment and their aid, to Professor Philippe Gailly and Dr. Olivier
   Schakman for providing the necessary equipment and the know-how for the
   in vivo functional tests. We thank Camille Pichon for her involvement in
   the analysis of micro-CT scans; Marie-Christine Many and Peter Van den
   Bergh for their help in the interpretation of TEM images; Veronique Van
   Den Berge and Corinne Picalausa for their technical support; Laura De
   Cock, Alice Monnier and Marie Clerbois for their participation in mice
   experiments and tissue analysis. We also thank Greetje Vande Velde
   (MoSAIC, KU Leuven) for providing the micro-CT scan and the personnel of
   the microscopy services (CITIUS, Universidad de Sevilla) for their
   technical support for transmission electron microscopy. All authors
   certify that they comply with the ethical guidelines for authorship and
   publishing in the Journal of Cachexia, Sarcopenia and Muscle.42
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NR 42
TC 20
Z9 20
U1 1
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2190-5991
EI 2190-6009
J9 J CACHEXIA SARCOPENI
JI J. Cachexia Sarcopenia Muscle
PD FEB
PY 2023
VL 14
BP 464
EP 478
DI 10.1002/jcsm.13148
EA DEC 2022
PG 15
WC Geriatrics & Gerontology; Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology; General & Internal Medicine
GA H4HS5
UT WOS:000897976400001
PM 36513619
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Kopf, JC
   Suhr, MJ
   Clarke, J
   Eyun, SI
   Riethoven, JJM
   Ramer-Tait, AE
   Rose, DJ
AF Kopf, Julianne C.
   Suhr, Mallory J.
   Clarke, Jennifer
   Eyun, Seong-il
   Riethoven, Jean-Jack M.
   Ramer-Tait, Amanda E.
   Rose, Devin J.
TI Role of whole grains versus fruits and vegetables in reducing
   subclinical inflammation and promoting gastrointestinal health in
   individuals affected by overweight and obesity: a randomized controlled
   trial
SO NUTRITION JOURNAL
LA English
DT Article
DE Metabolic syndrome; Gut microbiota; Interleukin-6; Lipopolysaccharide;
   Tumor necrosis factor-alpha; C-reactive protein; Short chain fatty acids
ID HUMAN COLONIC MICROBIOTA; C-REACTIVE PROTEIN; CHAIN FATTY-ACIDS; GUT
   MICROBIOTA; CRUCIFEROUS VEGETABLES; INTESTINAL MICROBIOTA;
   CARDIOVASCULAR RISK; OXIDATIVE STRESS; DASH DIET; MARKERS
AB Background: Whole grains (WG) and fruits and vegetables (FV) have been shown to reduce the risk of metabolic disease, possibly via modulation of the gut microbiota. The purpose of this study was to determine the impact of increasing intake of either WG or FV on inflammatory markers and gut microbiota composition.
   Methods: A randomized parallel arm feeding trial was completed on forty-nine subjects with overweight or obesity and low intakes of FV and WG. Individuals were randomized into three groups (3 servings/d provided): WG, FV, and a control (refined grains). Stool and blood samples were collected at the beginning of the study and after 6 weeks. Inflammatory markers [tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), lipopolysaccharide binding protein (LBP), and high sensitivity C-reactive protein (hs-CRP)] were measured. Stool sample analysis included short/branched chain fatty acids (S/BCFA) and microbiota composition.
   Results: There was a significant decrease in LBP for participants on the WG (-0.2 mu g/mL, p = 0.02) and FV (-0.2 mu g/mL, p = 0.005) diets, with no change in those on the control diet (0.1 mu g/mL, p = 0.08). The FV diet induced a significant change in IL-6 (-1.5 pg/mL, p = 0.006), but no significant change was observed for the other treatments (control, -0.009 pg/mL, p = 0.99; WG, -0.29, p = 0.68). The WG diet resulted in a significant decrease in TNF-alpha (-3.7 pg/mL; p < 0.001), whereas no significant effects were found for those on the other diets (control, -0.6 pg/mL, p = 0.6; FV, -1.4 pg/mL, p = 0.2). The treatments induced individualized changes in microbiota composition such that treatment group differences were not identified, except for a significant increase in alpha-diversity in the FV group. The proportions of Clostridiales (Firmicutes phylum) at baseline were correlated with the magnitude of change in LBP during the study.
   Conclusions: These data demonstrate that WG and FV intake can have positive effects on metabolic health; however, different markers of inflammation were reduced on each diet suggesting that the anti-inflammatory effects were facilitated via different mechanisms. The anti-inflammatory effects were not related to changes in gut microbiota composition during the intervention, but were correlated with microbiota composition at baseline.
C1 [Kopf, Julianne C.; Suhr, Mallory J.; Clarke, Jennifer; Ramer-Tait, Amanda E.; Rose, Devin J.] Univ Nebraska, Dept Food Sci & Technol, 1901 North 21st St, Lincoln, NE 68588 USA.
   [Clarke, Jennifer] Univ Nebraska, Dept Stat, Lincoln, NE USA.
   [Clarke, Jennifer; Ramer-Tait, Amanda E.; Rose, Devin J.] Univ Nebraska, Nebraska Food Hlth Ctr, 1901 North 21st St, Lincoln, NE 68588 USA.
   [Eyun, Seong-il] Chung Ang Univ, Dept Life Sci, Seoul, South Korea.
   [Riethoven, Jean-Jack M.] Univ Nebraska, Ctr Biotechnol, Lincoln, NE USA.
   [Rose, Devin J.] Univ Nebraska, Dept Agron & Hort, 1901 North 21st St, Lincoln, NE 68588 USA.
C3 University of Nebraska System; University of Nebraska Lincoln;
   University of Nebraska System; University of Nebraska Lincoln;
   University of Nebraska System; University of Nebraska Lincoln; Chung Ang
   University; University of Nebraska System; University of Nebraska
   Lincoln; University of Nebraska System; University of Nebraska Lincoln
RP Rose, DJ (corresponding author), Univ Nebraska, Dept Food Sci & Technol, 1901 North 21st St, Lincoln, NE 68588 USA.; Rose, DJ (corresponding author), Univ Nebraska, Nebraska Food Hlth Ctr, 1901 North 21st St, Lincoln, NE 68588 USA.
EM drose3@unl.edu
RI Ramer-Tait, Amanda/B-4542-2008; Eyun, Seong-il/Q-8872-2019
OI Suhr Van Haute, Mallory/0000-0002-2106-5124; Eyun,
   Seong-il/0000-0003-4687-1066; Clarke, Jennifer/0000-0002-2723-7249;
   Riethoven, Jean-Jack/0000-0002-2709-7880; Ramer-Tait,
   Amanda/0000-0003-0950-7548
FU Agricultural Research Division at the University of Nebraska-Lincoln;
   Nebraska Research Initiative
FX This project was funded by the Agricultural Research Division at the
   University of Nebraska-Lincoln (JK, JC, ARI, DR) and by the Nebraska
   Research Initiative (SE and JR). The funders were not involved in study
   design, data collection, analysis, or interpretation, or in preparation
   or submission of the manuscript for publication.
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NR 65
TC 71
Z9 78
U1 0
U2 26
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1475-2891
J9 NUTR J
JI Nutr. J.
PD JUL 30
PY 2018
VL 17
AR 72
DI 10.1186/s12937-018-0381-7
PG 13
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA GO9TQ
UT WOS:000440450900001
PM 30060746
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Umbaugh, DS
   Maciejewski, JC
   Wooten, JS
   Guilford, BL
AF Umbaugh, David S.
   Maciejewski, J. Claire
   Wooten, Joshua S.
   Guilford, Brianne L.
TI Neuronal Inflammation is Associated with Changes in Epidermal
   Innervation in High Fat Fed Mice
SO FRONTIERS IN PHYSIOLOGY
LA English
DT Article
DE peripheral neuropathy; prediabetes; intraepidermal nerve fiber density;
   von Frey; mechanical allodynia; TrkA; insulin resisitance
ID NERVE GROWTH-FACTOR; DIABETIC-NEUROPATHY; PERIPHERAL NEUROPATHY;
   NEUROTROPHIN TREATMENT; INDUCED HYPERALGESIA; PAINFUL NEUROPATHY;
   SENSORY NEUROPATHY; ALDOSE REDUCTASE; OXIDATIVE STRESS; ANIMAL-MODELS
AB Peripheral neuropathy (PN), a debilitating complication of diabetes, is associated with obesity and the metabolic syndrome in nondiabetic individuals. Evidence indicates that a high fat diet can induce signs of diabetic peripheral PN in mice but the pathogenesis of high fat diet-induced PN remains unknown. PURPOSE: Determine if neuronal inflammation is associated with the development of mechanical hypersensitivity and nerve fiber changes in high fat fed mice. METHODS: Male C57Bl/6 mice were randomized to a standard (Std, 15% kcal from fat) or high fat diet (HF, 54% kcal from fat) for 2, 4, or 8 weeks (n = 11-12 per group). Lumbar dorsal root ganglia were harvested and inflammatory mediators (IL-1 alpha, IL-1 beta, IL-2, IL-3, IL-4, IL-5, IL-6, IL-10, IL-12p70, IL-17, MCP-1, IFN-gamma, TNF-alpha, MIP-1 alpha, GMCSF, RANTES) were quantified. Hindpaw mechanical sensitivity was assessed using the von Frey test. Intraepidermal nerve fiber density (IENFD) and TrkA nerve fiber density were quantified via immunohistochemistry. RESULTS: After 8 weeks, HF had greater body mass (33.3 +/- 1.0 vs 26.7 +/- 0.5 g, p < 0.001), fasting blood glucose (160.3 +/- 9.4 vs 138.5 +/- 3.4 mg/dl, p < 0.05) and insulin (3.58 +/- 0.46 vs 0.82 +/- 0.14 ng/ml, p < 0.001) compared to Std. IL-1 alpha, RANTES and IL-5 were higher in HF compared to Std after 2 and 4 weeks, respectively (IL-1 alpha: 4.8 +/- 1.3 vs 2.9 +/- 0.6 pg/mg, p < 0.05; RANTES: 19.6 +/- 2.2 vs 13.3 +/- 1.2 pg/mg p < 0.05; IL-5: 5.8 +/- 0.7 vs 3.1 +/- 0.5 pg/mg, p < 0.05). IENFD and TrkA fiber density were also higher in HF vs Std after 4 weeks (IENFD: 39.4 +/- 1.2 vs 32.2 +/- 1.3 fibers/mm, p < 0.001; TrkA: 30.4 +/- 1.8 vs 22.4 +/- 1.3 fibers/mm). There were no significant differences in hindpaw sensitivity for Std vs HF. CONCLUSION: Increased inflammatory mediators preceded and accompanied an increase in cutaneous pain sensing nerve fibers in high fat fed mice but was not accompanied by significant mechanical allodynia. Diets high in fat may increase neuronal inflammation and lead to increased nociceptive nerve fiber density.
C1 [Umbaugh, David S.; Maciejewski, J. Claire; Wooten, Joshua S.; Guilford, Brianne L.] Southern Illinois Univ Edwardsville, Dept Appl Hlth, Edwardsville, IL 62026 USA.
C3 Southern Illinois University System; Southern Illinois University
   Edwardsville
RP Guilford, BL (corresponding author), Southern Illinois Univ Edwardsville, Dept Appl Hlth, Edwardsville, IL 62026 USA.
EM bguilfo@siue.edu
RI Wooten, Joshua/K-9703-2017; Umbaugh, David/ABD-6775-2021
OI Umbaugh, David/0000-0002-5327-9020
FU Southern Illinois University Edwardsville (SIUE) Graduate School;
   Undergraduate Research and Creative Activities Program at SIUE
FX This research was supported by Seed Grants for Transitional and
   Exploratory Projects and Research Grants for Graduate Students from
   Southern Illinois University Edwardsville (SIUE) Graduate School and the
   Undergraduate Research and Creative Activities Program at SIUE.
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NR 68
TC 5
Z9 5
U1 0
U2 3
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1664-042X
J9 FRONT PHYSIOL
JI Front. Physiol.
PD AUG 23
PY 2022
VL 13
AR 891550
DI 10.3389/fphys.2022.891550
PG 12
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA 6I4KU
UT WOS:000886096700001
PM 36082224
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Oswal, N
   Lizardo, K
   Dhanyalayam, D
   Ayyappan, JP
   Thangavel, H
   Heysell, SK
   Nagajyothi, JF
AF Oswal, Neelam
   Lizardo, Kezia
   Dhanyalayam, Dhanya
   Ayyappan, Janeesh P.
   Thangavel, Hariprasad
   Heysell, Scott K.
   Nagajyothi, Jyothi F.
TI Host Metabolic Changes during Mycobacterium Tuberculosis Infection Cause
   Insulin Resistance in Adult Mice
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Article
DE tuberculosis; type 2 diabetes; diet and age; insulin resistance; adipose
   tissue; inflammation; lipolysis; lipid and energy metabolism
ID ADIPOSE TRIGLYCERIDE LIPASE; LIPID-METABOLISM; KAPPA-B; LIPOLYSIS;
   INFLAMMATION; ADIPONECTIN; IMPACT; TISSUE; RISK; ATGL
AB Tuberculosis (TB) is a highly infectious bacterial disease that primarily attacks the lungs. TB is manifested either as latent TB infection (LTBI) or active TB disease, the latter posing a greater threat to life. The risk of developing active TB disease from LTBI is three times higher in individuals with type 2 diabetes mellitus (T2DM). The association between TB and T2DM is becoming more prominent as T2DM is rapidly increasing in settings where TB is endemic. T2DM is a chronic metabolic disorder characterized by elevated blood glucose, insulin resistance, and relative insulin deficiency. Insulin resistance and stress-induced hyperglycemia have been shown to be increased by TB and to return to normal upon treatment. Previously, we demonstrated that adipocytes (or fat tissue) regulate pulmonary pathology, inflammation, and Mycobacterium tuberculosis (Mtb) load in a murine model of TB. Metabolic disturbances of adipose tissue and/or adipocyte dysfunction contribute to the pathogenesis of T2DM. Thus, pathological adipocytes not only regulate pulmonary pathology, but also increase the risk for T2DM during TB infection. However, the cellular and molecular mechanisms driving the interaction between hyperglycemia, T2DM and TB remain poorly understood. Here, we report the impact of Mtb infection on the development of insulin resistance in mice fed on a regular diet (RD) versus high-fat diet (HFD) and, conversely, the effect of hyperglycemia on pulmonary pathogenesis in juvenile and adult mouse models. Overall, our study demonstrated that Mtb persists in adipose tissue and that Mtb infection induces irregular adipocyte lipolysis and loss of fat cells via different pathways in RD- and HFD-fed mice. In RD-fed mice, the levels of TNF alpha and HSL (hormone sensitive lipase) play an important role whereas in HFD-fed mice, ATGL (adipose triglyceride lipase) plays a major role in regulating adipocyte lipolysis and apoptosis during Mtb infection in adult mice. We also showed that Mtb infected adult mice that were fed an RD developed insulin resistance similar to infected adult mice that were overweight due to a HFD diet. Importantly, we found that a consequence of Mtb infection was increased lipid accumulation in the lungs, which altered cellular energy metabolism by inhibiting major energy signaling pathways such as insulin, AMPK and mToR. Thus, an altered balance between lipid metabolism and glucose metabolism in adipose tissue and other organs including the lungs may be an important component of the link between Mtb infection and subsequent metabolic syndrome.
C1 [Oswal, Neelam; Lizardo, Kezia; Dhanyalayam, Dhanya; Thangavel, Hariprasad; Nagajyothi, Jyothi F.] Hackensack Univ, Ctr Discovery & Innovat, Med Ctr, Hackensack, NJ 07110 USA.
   [Ayyappan, Janeesh P.] Univ Kerala, Dept Biochem, Thiruvananthapuram 695034, Kerala, India.
   [Heysell, Scott K.] Univ Virginia, Div Infect Dis & Int Hlth, Charlottesville, VA 22908 USA.
C3 Hackensack University Medical Center; University of Kerala; University
   of Virginia
RP Nagajyothi, JF (corresponding author), Hackensack Univ, Ctr Discovery & Innovat, Med Ctr, Hackensack, NJ 07110 USA.
EM neelam.oswal@hmh-cdi.org; kezia.lizardo@hmh-cdi.org;
   dhanya.dhanyalayam@hmh-cdi.org;
   janeeshbiochemistry@keralauniversity.ac.in;
   hariprasad.thangavel@hmh-cdi.org; skh8r@hscnaail.mcc.virginia.edu;
   jyothi.nagajyothi@hmh-cdi.org
RI Oswal, Neelam/AAT-7680-2021
OI Oswal, Neelam/0000-0002-3531-5948; Thangavel,
   Hariprasad/0000-0001-5119-2661; PLAKKAL AYYAPPAN,
   JANEESH/0000-0001-8074-3709
FU National Institute of Allergy and Infectious Diseases (National
   Institutes of Health) [AI150765-01]; National Institute of Allergy and
   Infectious Diseases [R01AI137080] Funding Source: NIH RePORTER
FX This study was supported by grants from the National Institute of
   Allergy and Infectious Diseases (National Institutes of Health
   AI150765-01) to Jyothi Nagajyothi.
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NR 63
TC 17
Z9 18
U1 1
U2 2
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD MAR
PY 2022
VL 11
IS 6
AR 1646
DI 10.3390/jcm11061646
PG 21
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 0C1QT
UT WOS:000775096900001
PM 35329973
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Meng, HY
   Zhu, L
   Kord-Varkaneh, H
   Santos, HO
   Tinsley, GM
   Fu, P
AF Meng, Haiyan
   Zhu, Lei
   Kord-Varkaneh, Hamed
   Santos, Heitor O.
   Tinsley, Grant M.
   Fu, Peng
TI Effects of intermittent fasting and energy-restricted diets on lipid
   profile: A systematic review and meta-analysis
SO NUTRITION
LA English
DT Review
DE Intermittent fasting; Energy-restricted diet; Lipids; Low-density
   lipoprotein cholesterol; High-density lipoprotein cholesterol;
   Triacylglycerols; Meta-analysis
ID DENSITY-LIPOPROTEIN CHOLESTEROL; LOW-CALORIE DIET; BODY-COMPOSITION;
   WEIGHT-LOSS; METABOLIC SYNDROME; OXIDATIVE STRESS; MARKED INCREASE;
   PROTEIN-INTAKE; HEART-DISEASE; RISK-FACTORS
AB Objectives: To the best of our knowledge, no systematic review and meta-analysis has evaluated the cholesterol-lowering effects of intermittent fasting (IF) and energy-restricted diets (ERD) compared with control groups. The aim of this review and meta-analysis was to summarize the effects of controlled clinical trials examining the influence of IF and ERD on lipid profiles.
   Methods: A systematic review of four independent databases (PubMed/Medline, Scopus, Web of Science and Google Scholar) was performed to identify clinical trials reporting the effects of IF or ERD, relative to non-diet controls, on lipid profiles in humans. A random-effects model, employing the method of DerSimonian and Laird, was used to evaluate effect sizes, and results were expressed as weighted mean difference (WMD) and 95% confidence intervals (CIs). Heterogeneity between studies was calculated using Higgins I-2, with values >= 50% considered to represent high heterogeneity. Subgroup analyses were performed to examine the influence of intervention type, baseline lipid concentrations, degree of energy deficit, sex, health status, and intervention duration.
   Results: For the outcomes of low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), and triacylglycerols (TG), there were 34, 33, 35, and 33 studies meeting all inclusion criteria, respectively. Overall, results from the random-effects model indicated that IF and ERD interventions resulted significant changes in TC (WMD, -6.93 mg/dL; 95% CI, -10.18 to -3.67; P < 0.001; I-2 = 78.2%), LDL-C (WMD, -6.16 mg/dL; 95% CI, -8.42 to -3.90; P < 0.001; I-2 = 52%), and TG concentrations (WMD, -6.46 mg/dL; 95% CI, -10.64 to -2.27; P = 0.002; I-2 = 61%). HDL-C concentrations did not change significantly after IF or ERD (WMD, 0.50 mg/dL; 95% CI, -0.69 to 1.70; P = 0.411; I-2 = 80%). Subgroup analyses indicated potentially differential effects between subgroups for one or more lipid parameters in the majority of analyses.
   Conclusions: Relative to a non-diet control, IF and ERD are effective for the improvement of circulating TC, LDL-C, and TG concentrations, but have no meaningful effects on HDL-C concentration. These effects are influenced by several factors that may inform clinical practice and future research. The present results suggest that these dietary practices are a means of enhancing the lipid profile in humans. (C) 2020 Elsevier Inc. All rights reserved.
C1 [Meng, Haiyan] Shandong Prov Third Hosp, Dept Cardiovasc Med, Jinan, Shandong, Peoples R China.
   [Zhu, Lei; Fu, Peng] Shandong Prov Third Hosp, Dept Endocrinol, Shadowless Hill Rd, Jinan, Shandong, Peoples R China.
   [Kord-Varkaneh, Hamed] Shahid Beheshti Univ Med Sci, Fac Nutr & Food Technol, Dept Clin Nutr & Dietet, Student Res Comm, Tehran, Iran.
   [Santos, Heitor O.] Fed Univ Uberlandia UFU, Sch Med, Uberlandia, MG, Brazil.
   [Tinsley, Grant M.] Texas Tech Univ, Dept Kinesiol & Sport Management, Lubbock, TX 79409 USA.
C3 Shahid Beheshti University Medical Sciences; Universidade Federal de
   Uberlandia; Texas Tech University System; Texas Tech University
RP Fu, P (corresponding author), Shandong Prov Third Hosp, Dept Endocrinol, Shadowless Hill Rd, Jinan, Shandong, Peoples R China.
EM garuda1981@126.com
RI Fu, Peng/D-6010-2017; Tinsley, Grant/S-4582-2019
OI Tinsley, Grant/0000-0002-0230-6586; kord varkaneh,
   hamed/0000-0001-7675-4405
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NR 79
TC 103
Z9 106
U1 1
U2 35
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0899-9007
EI 1873-1244
J9 NUTRITION
JI Nutrition
PD SEP
PY 2020
VL 77
AR 110801
DI 10.1016/j.nut.2020.110801
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA NM0TT
UT WOS:000567818300005
PM 32428841
DA 2025-06-11
ER

PT J
AU Heath, P
   Claus, SP
AF Heath, Peter
   Claus, Sandrine Paule
TI Assessing Hepatic Metabolic Changes During Progressive Colonization of
   Germ-free Mouse by <SUP>1</SUP>H NMR Spectroscopy
SO JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
LA English
DT Article
DE Immunology; Issue 58; Germ-free animal; colonization; NMR; HR MAS NMR;
   metabonomics
ID SPINNING NMR-SPECTROSCOPY; PATTERN-RECOGNITION; TISSUE; H-1; MICROFLORA;
   PROFILES; OBESITY; MODELS; HEALTH; IMPACT
AB It is well known that gut bacteria contribute significantly to the host homeostasis, providing a range of benefits such as immune protection and vitamin synthesis. They also supply the host with a considerable amount of nutrients, making this ecosystem an essential metabolic organ. In the context of increasing evidence of the link between the gut flora and the metabolic syndrome, understanding the metabolic interaction between the host and its gut microbiota is becoming an important challenge of modern biology.(1-4)
   Colonization (also referred to as normalization process) designates the establishment of micro-organisms in a former germ-free animal. While it is a natural process occurring at birth, it is also used in adult germ-free animals to control the gut floral ecosystem and further determine its impact on the host metabolism. A common procedure to control the colonization process is to use the gavage method with a single or a mixture of micro-organisms. This method results in a very quick colonization and presents the disadvantage of being extremely stressful(5). It is therefore useful to minimize the stress and to obtain a slower colonization process to observe gradually the impact of bacterial establishment on the host metabolism.
   In this manuscript, we describe a procedure to assess the modification of hepatic metabolism during a gradual colonization process using a non-destructive metabolic profiling technique. We propose to monitor gut microbial colonization by assessing the gut microbial metabolic activity reflected by the urinary excretion of microbial co-metabolites by H-1 NMR-based metabolic profiling. This allows an appreciation of the stability of gut microbial activity beyond the stable establishment of the gut microbial ecosystem usually assessed by monitoring fecal bacteria by DGGE (denaturing gradient gel electrophoresis).(6) The colonization takes place in a conventional open environment and is initiated by a dirty litter soiled by conventional animals, which will serve as controls. Rodents being coprophagous animals, this ensures a homogenous colonization as previously described.(7)
   Hepatic metabolic profiling is measured directly from an intact liver biopsy using H-1 High Resolution Magic Angle Spinning NMR spectroscopy. This semi-quantitative technique offers a quick way to assess, without damaging the cell structure, the major metabolites such as triglycerides, glucose and glycogen in order to further estimate the complex interaction between the colonization process and the hepatic metabolism(7-10). This method can also be applied to any tissue biopsy(11,12).
C1 [Heath, Peter] Univ Reading, Sch Chem Food & Pharm, Reading RG6 2AH, Berks, England.
   [Claus, Sandrine Paule] Univ Reading, Dept Nutr Sci, Reading RG6 2AH, Berks, England.
C3 University of Reading; University of Reading
RP Claus, SP (corresponding author), Univ Reading, Dept Nutr Sci, Reading RG6 2AH, Berks, England.
EM s.p.claus@reading.ac.uk
OI Claus, Sandrine/0000-0002-3789-9780
FU Nestle
FX All NMR spectra used as illustrative examples are derived from a
   previously published study<SUP>7</SUP> which was financially supported
   by Nestle.
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NR 37
TC 4
Z9 4
U1 0
U2 5
PU JOURNAL OF VISUALIZED EXPERIMENTS
PI CAMBRIDGE
PA 1 ALEWIFE CENTER, STE 200, CAMBRIDGE, MA 02140 USA
SN 1940-087X
J9 JOVE-J VIS EXP
JI J. Vis. Exp.
PD DEC
PY 2011
IS 58
AR e3642
DI 10.3791/3642
PG 7
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA V36PA
UT WOS:000209222300039
PM 22215201
OA Green Published
DA 2025-06-11
ER

PT J
AU Yokoyama, K
   Yamada, Y
   Akamatsu, Y
   Yoshinaka, Y
   Yamamoto, A
   Koizumi, T
   Ohyama, K
   Suzuki, K
   Hashimoto, M
   Sato, H
   Kimura, M
AF Yokoyama, Keiichi
   Yamada, Yosuke
   Akamatsu, Yasunori
   Yoshinaka, Yasuko
   Yamamoto, Akiko
   Koizumi, Tomonori
   Ohyama, Kana
   Suzuki, Katsuya
   Hashimoto, Masaki
   Sato, Hitoshi
   Kimura, Misaka
TI Effects of Capsinoids on Daily Physical Activity, Body Composition and
   Cold Hypersensitivity in Middle-Aged and Older Adults: A Randomized
   Study
SO NUTRIENTS
LA English
DT Article
DE capsinoids; brown adipose tissue; physical activity; percent body fat;
   visceral fat; energy metabolism; energy expenditure; chilly sensation;
   brain inflammation; clinical
ID CAPSAICINOID-LIKE SUBSTANCES; HEALTH-BENEFITS; CH-19 SWEET;
   CARDIOVASCULAR-DISEASE; SEDENTARY BEHAVIORS; BLOOD-PRESSURE; CAPSIATE;
   RISK; DEMENTIA; PEPPER
AB Sedentary/inactive lifestyle leads middle-aged and older adults to metabolic syndrome and frailty. Capsinoids from nonpungent chili pepper cultivar have been reported to reduce body fat mass, promote metabolism, and improve unidentified complaints of chills. Additionally, they have an anti-inflammation effect; therefore, we hypothesized that continuous oral ingestion of capsinoids alleviates age-related inflammation in the brain and improves the physical activity (PA) in middle-aged and older adults. In our double-blind human study, 69 participants (17 male, 52 female; mean age: 74.1 +/- 7.7 years; range: 52-87 years) were administered either 9 mg of capsinoids which were extracted from pepper fruit variety CH-19 Sweet (Capsicum anuum L.) (CP group), or a placebo (PL group) daily over a 3 month period. In an animal study, PA and inflammation-related mRNA expression in the brain were examined in 5-week (young) and 53-week (old) aged mice fed a diet with or without 0.3% dihydrocapsiate, a type of capsinoids, for 12 weeks. In a human study, capsinoids intake did not increase the amount of light-to-moderate PA less than 6.0 metabolic equivalents (METs) (CP: 103.0 +/- 28.2 at baseline to 108.2 +/- 28.3 at 12 weeks; PL: 104.6 +/- 19.8 at baseline to 115.2 +/- 23.6 at 12 weeks, METs x hour/week); however, in participants exhibiting an inactive lifestyle, it showed significant increase (CP: 84.5 +/- 17.2 at baseline to 99.2 +/- 24.9 at 12 weeks; PL: 99.7 +/- 23.3 at baseline to 103.8 +/- 21.9 at 12 weeks). The energy expenditure in physical activity also improved in the inactive CP group (CP: 481.2 +/- 96.3 at baseline to 562.5 +/- 145.5 at 12 weeks; PL: 536.8 +/- 112.2 at baseline to 598.6 +/- 127.6 at 12 weeks; kcal/day). In all participants, CP showed reduced waist circumference, percent body fat, and visceral fat volume; in addition, chills were eased in subjects aged 80 years and older. The older mice fed capsinoids showed increased locomotion activity, decreased inflammation, and oxidative stress in the brain. The results suggest that the continuous oral ingestion of capsinoids gains PA through anti-inflammation effect in the brain as well as reduces fat accumulation and chills in inactive and older humans.
C1 [Yokoyama, Keiichi; Yamada, Yosuke; Kimura, Misaka] Kyoto Univ Adv Sci, Inst Act Hlth, Inst Interdisciplinary Res, 1-1 Nanjo Otani,Sogabe Cho, Kameoka City, Kyoto 6218555, Japan.
   [Yokoyama, Keiichi; Yamada, Yosuke; Yoshinaka, Yasuko; Kimura, Misaka] Nonprofit Org Genki Up AGE Project, Kameoka City, Kyoto 6218555, Japan.
   [Akamatsu, Yasunori; Yoshinaka, Yasuko] Kyoto Univ Adv Sci, Ctr Fac Dev, 1-1 Nanjo Otani,Sogabe Cho, Kameoka City, Kyoto 6218555, Japan.
   [Akamatsu, Yasunori] Natl Hosp Org Kyoto Med Ctr, Dept Endocrinol Metab & Hypertens Res, Clin Res Inst, Fushimi Ku, 1-1 Mukaihata Cho, Kyoto, Kyoto 6128555, Japan.
   [Yamamoto, Akiko; Koizumi, Tomonori; Suzuki, Katsuya] Ajinomoto Co Inc, Inst Food Sci & Technol, Kawasaki Ku, 1-1 Suzuki Cho, Kawasaki, Kanagawa 2108681, Japan.
   [Ohyama, Kana] Ajinomoto Co Inc, Task Force Nutr Strategy, Chuo Ku, 15-1,Kyobashi 1 Chome, Tokyo 1048315, Japan.
   [Hashimoto, Masaki] Ajinomoto Co Inc, Direct Mkt Dept, Chuo Ku, 15-1,Kyobashi 1 Chome, Tokyo 1048315, Japan.
   [Sato, Hitoshi] Ajinomoto Co Inc, Qual Assurance Dept, Chuo Ku, 15-1,Kyobashi 1 Chome, Tokyo 1048315, Japan.
C3 Ajinomoto Co Inc; Ajinomoto Co Inc; Ajinomoto Co Inc; Ajinomoto Co Inc
RP Yokoyama, K (corresponding author), Kyoto Univ Adv Sci, Inst Act Hlth, Inst Interdisciplinary Res, 1-1 Nanjo Otani,Sogabe Cho, Kameoka City, Kyoto 6218555, Japan.; Yokoyama, K (corresponding author), Nonprofit Org Genki Up AGE Project, Kameoka City, Kyoto 6218555, Japan.
EM physiol.yokoyama@gmail.com; yamada.yousuke@kuas.ac.jp;
   akamatsu.yasunori@gmail.com; yoshinaka.yasuko@kuas.ac.jp;
   akiko_yamamoto01@ajinomoto.com; tomonori_koizumi@ajinomoto.com;
   kana_oyama@ajinomoto.com; katsuya_suzuki@ajinomoto.com;
   masaki_hashimoto@ajinomoto.com; hitoshi_sato@ajinomoto.com;
   kimura.misaka@kuas.ac.jp
RI Yamada, Yosuke/AAX-7073-2020
OI Yoshinaka, Yasuko/0000-0001-6524-1954; Akamatsu,
   Yasunori/0000-0002-1285-595X; Yamada, Yosuke/0000-0002-4284-6317
FU Ajinomoto Co.
FX This study was funded by Ajinomoto Co. Inc.
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NR 49
TC 12
Z9 12
U1 0
U2 16
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JAN
PY 2020
VL 12
IS 1
AR 212
DI 10.3390/nu12010212
PG 23
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nutrition & Dietetics
GA KQ3KN
UT WOS:000516825500212
PM 31947529
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Vitzthum, VJ
   Thornburg, J
   McDade, TW
   Hicks, KA
   Miller, A
   Chester, EM
   Goodlett, B
   Caceres, E
   Spielvogel, H
AF Vitzthum, Virginia J.
   Thornburg, Jonathan
   McDade, Thomas W.
   Hicks, Kathryn A.
   Miller, Aaron
   Chester, Emily M.
   Goodlett, Baileigh
   Caceres, Esperanza
   Spielvogel, Hilde
TI C-reactive protein (CRP) in high altitude Bolivian peri-urban
   adolescents varies by adiposity, current illness, height, socioeconomic
   status, sex, and menarcheal status: The potential benefits and costs of
   adipose reserves in arduous environments
SO AMERICAN JOURNAL OF HUMAN BIOLOGY
LA English
DT Article
ID LOW-GRADE INFLAMMATION; SPONTANEOUS MENSTRUAL-CYCLE; LIFE-HISTORY
   THEORY; METABOLIC-SYNDROME; CENTILE CURVES; IMMUNE-SYSTEM; LMS METHOD;
   CHILDREN; GROWTH; PREDICTORS
AB Objectives: In non-industrialized and low-income populations, adipose stores can serve as a valuable buffer against harsh conditions such as seasonal food scarcity. However, these reserves may incur costs due to adipocytes' production of pro-inflammatory cytokines; inflammation is associated with increased risk for cardiometabolic diseases later in life. Life history theory posits that, especially in populations with high juvenile mortality, higher adiposity may nonetheless be advantageous if its benefits in early life outweigh its later costs. Relatively little is known about adolescents' C-reactive protein concentration (CRP; an inflammation biomarker) in such environments. We investigated CRP and its associations with several hypothesized predictors in adolescents in an economically diverse peri-urban Andean community.
   Methods: We measured CRP in dried blood spots and collected data on anthropometrics, illnesses, socioeconomic status (SES), and menarcheal status in 59 female and 40 male adolescents ("Altenos", 11.0-14.9 years old) with normal vital signs in El Alto, Bolivia (similar to 4150 m amsl). We used Cole's LMS method to standardize all anthropometrics for sex and age, and principal components analysis to construct a "fat-factor" variable loading on these standardized z-scores. We used multiple linear regression to assess the influence of fat-factor and other likely predictors on CRP rank.
   Results: Compared to a national Bolivian growth reference, Altenos were, on average, shorter and leaner; only 6% were classified as overweight and none were obese. Pre-menarche females were on average leaner than post-menarche females. The best-fitting model explained 24% of the variance in CRP rank. Significant predictors were fat-factor, SES, current illness for males and pre-menarche females, and z-height for females.
   Conclusions: Our results are consistent with a tradeoff between investments in growth versus immune functioning, as might be expected in an environment with limited resources and high pathogen exposure (e.g., soil-transmitted helminths, poor sanitation). Thinner Altenos appear to maintain a minimum CRP concentration independent of fat-factor, while fatter (or less-thin) Altenos' CRP rises with fat-factor. Female Altenos appear to be trading off investment in immune response for investment in growth and maturation. Altenos' high rate of stunting and absence of obesity suggests chronic, presumably multifactorial, stress. Adipose stores likely buffer against some of these stressors and, in an environment such as this-in which many lack sufficient nutritious foods, potable water, adequate sewage, and health care-may confer a net lifetime benefit.
C1 [Vitzthum, Virginia J.; Chester, Emily M.] Indiana Univ, Dept Anthropol, Bloomington, IN USA.
   [Vitzthum, Virginia J.] Univ British Columbia, Ctr Menstrual Cycle & Ovulat Res, Dept Med, Vancouver, BC, Canada.
   [Vitzthum, Virginia J.; Thornburg, Jonathan] BKIS Orchards, Thetis Isl, BC, Canada.
   [Thornburg, Jonathan] Indiana Univ, Ctr Spacetime Symmetries, Bloomington, IN USA.
   [McDade, Thomas W.; Hicks, Kathryn A.; Miller, Aaron] Northwestern Univ, Dept Anthropol, Evanston, IL USA.
   [Goodlett, Baileigh] Indiana Univ, Human Biol Program, Bloomington, IN USA.
   [Caceres, Esperanza; Spielvogel, Hilde] Inst Boliviano Biol Altura IBBA, La Paz, Bolivia.
   [Vitzthum, Virginia J.] Indiana Univ, Bloomington, IN 47405 USA.
   [Hicks, Kathryn A.] Univ Memphis, Dept Anthropol, Memphis, TN USA.
   [Chester, Emily M.] Auburn Univ, Coll Vet Med, Auburn, AL USA.
C3 Indiana University System; Indiana University Bloomington; University of
   British Columbia; Indiana University System; Indiana University
   Bloomington; Northwestern University; Indiana University System; Indiana
   University Bloomington; Indiana University System; Indiana University
   Bloomington; University of Memphis; Auburn University System; Auburn
   University
RP Vitzthum, VJ (corresponding author), Indiana Univ, Bloomington, IN 47405 USA.
EM vitzthum@iu.edu
OI McDade, Thomas/0000-0001-5829-648X; , Aaron/0000-0003-2744-8916;
   Vitzthum, Virginia J./0000-0002-6765-4557
FU CIFAR Child and Brain Development Program; U.S. National Science
   Foundation; Northwestern University Latin American and Caribbean Studies
   Summer Funding Grant (KAH)
FX This work is dedicated to the memory of our friend and collaborator,
   Dra. Lieselotte Bauer de Barragan, who was Director of the Foundation
   for the Hospital San Gabriel, La Paz (the first Baby Friendly Hospital
   in Bolivia) and a tireless advocate for children's and women's health
   throughout her professional life. We deeply appreciate the El Alto
   school teachers' thoughtful guidance, commitment, and unflagging good
   humor. We are grateful to all the parents and students for their
   interest and patience. Funding for data collection provided by the U.S.
   National Science Foundation (VJV), and a Northwestern University Latin
   American and Caribbean Studies Summer Funding Grant (KAH); and for
   laboratory work at Northwestern University by the CIFAR Child and Brain
   Development program (TWM).
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NR 69
TC 3
Z9 3
U1 1
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1042-0533
EI 1520-6300
J9 AM J HUM BIOL
JI Am. J. Hum. Biol.
PD SEP
PY 2024
VL 36
IS 9
AR e24107
DI 10.1002/ajhb.24107
EA JUN 2024
PG 15
WC Anthropology; Biology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Anthropology; Life Sciences & Biomedicine - Other Topics
GA K2D7Y
UT WOS:001237564900001
PM 38828631
OA hybrid
DA 2025-06-11
ER

PT J
AU Duan, YP
   Liang, W
   Guo, L
   Wienert, J
   Yan, G
   Si, GY
   Lippke, S
AF Duan, Yan Ping
   Liang, Wei
   Guo, Lan
   Wienert, Julian
   Yan, Gang
   Si, Gang Yan
   Lippke, Sonia
TI Evaluation of a Web-Based Intervention for Multiple Health Behavior
   Changes in Patients With Coronary Heart Disease in Home-Based
   Rehabilitation: Pilot Randomized Controlled Trial
SO JOURNAL OF MEDICAL INTERNET RESEARCH
LA English
DT Article
DE eHealth; physical activity; diet; cardiac rehabilitation; health
   resources
ID PHYSICAL-ACTIVITY; CARDIAC REHABILITATION; METABOLIC SYNDROME;
   SELF-REGULATION; EXERCISE; DIET; VALIDITY; LIFE; RELIABILITY; EFFICACY
AB Background: Web-based and theory-based interventions for multiple health behaviors appears to be a promising approach with respect to the adoption and maintenance of a healthy lifestyle in cardiac patients who have been discharged from the hospital. Until now, no randomized controlled trials have tested this assumption among Chinese rehabilitation patients with coronary heart disease using a Web-based intervention.
   Objective: The study aim was to evaluate the effect of an 8-week Web-based intervention in terms of physical activity (PA), fruit and vegetable consumption (FVC), lifestyle changes, social-cognitive outcomes, and health outcomes compared with a waiting control group in Chinese cardiac patients. The intervention content was theory-based on the health action process approach Self-reported data were evaluated, including PA, FVC, healthy lifestyle (the synthesis of PA and FVC), internal resources (combination of intention, self-efficacy, and planning), and an external resource (social support) of PA and FVC behaviors, as well as perceived health outcomes (body mass index, quality of life, and depression).
   Methods: In a randomized controlled trial, 136 outpatients with coronary heart disease from the cardiac rehabilitation center of a hospital in China were recruited. After randomization and exclusion of unsuitable participants, 114 patients were assigned to 1 of the 2 groups: (1) the intervention group: first 4 weeks on PA and subsequent 4 weeks on FVC and (2) the waiting control group. A total of 2 Web-based assessments were conducted, including 1 at the beginning of the intervention (T1, N=114), and 1 at the end of the 8-week intervention (T2, N=83). The enrollment and follow-up took place from December 2015 to May 2016.
   Results: The Web-based intervention outperformed the control condition for PA, FVC, internal resources of PA and FVC, and an external resource of FVC, with an eta-squared effect size ranging from 0.06 to 0.43. Furthermore, the intervention effect was seen in the improvement of quality of life (F-1,F-79 =16.36, P<.001, eta(2)=.17). When predicting a healthy lifestyle at follow-up, baseline lifestyle (odds ratio, OR 145.60, 95% CI 11.24-1886; P<.001) and the intervention (OR 21.32, 95% CI 2.40-189.20; P=.006) were found to be significant predictors. Internal resources for FVC mediated the effect of the intervention on the adoption of a healthy lifestyle (R-adj(2)=.29; P=.001), indicating that if the intervention increased the internal resource of behavior, the adoption of a healthy lifestyle was more likely.
   Conclusions: Patients' psychological resources such as motivation, self-efficacy, planning, and social support as well as lifestyle can be improved by a Web-based intervention that focuses on both PA and FVC. Such an intervention enriches extended rehabilitation approaches for cardiac patients to be active and remain healthy in daily life after hospital discharge.
C1 [Duan, Yan Ping; Liang, Wei] Hong Kong Baptist Univ, Fac Social Sci, Dept Sport & Phys Educ, 12-F Shek Mun Campus,8 On Muk St, Shatin, Hong Kong, Peoples R China.
   [Guo, Lan] Guangdong Gen Hosp, Cardiac Rehabil Ctr, Guangzhou, Guangdong, Peoples R China.
   [Wienert, Julian; Lippke, Sonia] Jacobs Univ Bremen, Dept Psychol & Methods, Bremen, Germany.
   [Si, Gang Yan] Hong Kong Sports Inst, Sport Psychol Ctr, Hong Kong, Hong Kong, Peoples R China.
C3 Hong Kong Baptist University; Guangdong Academy of Medical Sciences &
   Guangdong General Hospital; Constructor University
RP Duan, YP (corresponding author), Hong Kong Baptist Univ, Fac Social Sci, Dept Sport & Phys Educ, 12-F Shek Mun Campus,8 On Muk St, Shatin, Hong Kong, Peoples R China.
EM duanyp@hkbu.edu.hk
RI Wienert, Julian/J-6458-2019; Yan, Gang/B-9020-2009; Lippke,
   Sonia/B-7564-2014; Liang, Wei/JYO-8476-2024
OI GUO, Lan/0000-0002-9073-0888; Duan, Yanping/0000-0002-6432-7542; Lippke,
   Sonia/0000-0002-8272-0399; Wienert, Julian/0000-0003-1246-7591; Liang,
   Wei/0000-0002-8120-7905
FU Wilhelm-Stiftung fur Rehabilitationsforschung in Germany; Hong Kong
   Baptist University in Hong Kong [FRG1/12-13/064]
FX This research was supported by a junior research group grant from the
   Wilhelm-Stiftung fur Rehabilitationsforschung in Germany and Faculty
   Research Grant from Hong Kong Baptist University in Hong Kong
   (FRG1/12-13/064). All authors would like to thank Ms Guilan Wu, the
   chief nurse of Cardiac Rehabilitation Centre of Guangdong General
   Hospital, for her active assistance and engagement in recruiting cardiac
   patients during the research process.
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NR 44
TC 75
Z9 80
U1 2
U2 55
PU JMIR PUBLICATIONS, INC
PI TORONTO
PA 130 QUEENS QUAY E, STE 1102, TORONTO, ON M5A 0P6, CANADA
SN 1438-8871
J9 J MED INTERNET RES
JI J. Med. Internet Res.
PD NOV 19
PY 2018
VL 20
IS 11
AR e12052
DI 10.2196/12052
PG 13
WC Health Care Sciences & Services; Medical Informatics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services; Medical Informatics
GA HC4KO
UT WOS:000451772600001
PM 30455167
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Mikelsaar, M
   Stsepetova, J
   Hütt, P
   Kolk, H
   Sepp, E
   Loivukene, K
   Zilmer, K
   Zilmer, M
AF Mikelsaar, Marika
   Stsepetova, Jelena
   Hutt, Pirje
   Kolk, Helgi
   Sepp, Epp
   Loivukene, Krista
   Zilmer, Kersti
   Zilmer, Mihkel
TI Intestinal Lactobacillus sp is associated with some cellular and
   metabolic characteristics of blood in elderly people
SO ANAEROBE
LA English
DT Article
DE Intestinal lactobacilli; Elderly; Blood WBC count; Blood Glucose; Blood
   ox-LDL
ID LOW-DENSITY-LIPOPROTEIN; LACTIC-ACID BACTERIA; OXIDATIVE STRESS;
   RIBOSOMAL-RNA; OLDER-ADULTS; IDENTIFICATION; MICROBIOTA; CATALASE;
   OBESITY; DIVERSITY
AB The higher counts or particular groups (Firmicutes/Bacteroidetes) of intestinal microbiota are related to host metabolic reactions, supporting a balance of human ecosystem. We further explored whether intestinal lactobacilli were associated with some principal cellular and metabolic markers of blood in 38 healthy >65-year-old persons. The questionnaire, routine clinical and laboratory data of blood indices as much as the oxidized low-density lipoprotein (ox-LDL) and baseline diene conjugates in low-density lipoprotein (BDC-LDL) of blood sera were explored. The PCR-based intestinal Lactobacillus sp. composition and counts of cultivable lactobacilli (LAB) were tested. The facultative heterofermentative lactobacilli (Lactobacillus casei and Lactobacillus paracasei) were the most frequent (89 and 97%, respectively) species found, while Lactobacillus acidophilus, Lactobacillus plantarum and Lactobacillus reuteri were present in almost half of the elderly persons. The number of species simultaneously colonizing the individuals ranged from 1 to 7 (median 4). In elderly consuming probiotics the LAB counts were significantly higher than in these not consuming (median 7.8, range 4.2-10.8 vs. median 6.3, range 3.3-9.7 log cfu/g; p = 0.005), adjusted (OR = 1.71, CI95 1.04-2.82; p = 0.035) for age and body mass index (BMI). The colonization by L acidophilus was negatively related (r = -0.367, p = 0.0275) to L reuteri, staying significant after adjusting for age, sex and BMI (OR = 0.16, CI95 0.04-0.73; p = 0.018). However, the blood glucose concentration showed a tendency for a negative correlation for colonization with Lactobacillus fermentum (r = -0.309, p = 0.062) adjusted for BMI (Adj. R-2 = 0.181; p = 0.013) but not for age and sex. The higher white blood cells (WBC) count was positively related (r = 0.434, p = 0.007) to presence of Lactobacillus reuteri adjusted for age, sex and BMI (Adj. R-2 = 0.193, p = 0.027). The lower values of ox-LDL were predicted by higher counts of cultivable lactobacilli adjusted by sex, age and BMI (r = -0.389, p = 0.016; Adj. R-2 = 0.184 p = 0.029). In conclusion, the pilot study of elderly persons shows that the intestinal lactobacilli are tightly associated with WBC count, blood glucose and content of ox-LDL which all serve as risk markers in pathogenesis of inflammation, metabolic syndrome and cardiovascular disease (CVD). (C) 2010 Elsevier Ltd. All rights reserved.
C1 [Mikelsaar, Marika; Stsepetova, Jelena; Hutt, Pirje; Sepp, Epp] Univ Tartu, Fac Med, Dept Microbiol, EE-50411 Tartu, Estonia.
   [Zilmer, Kersti; Zilmer, Mihkel] Univ Tartu, Fac Med, Dept Biochem, EE-50411 Tartu, Estonia.
   [Kolk, Helgi] Univ Tartu, Dept Traumatol & Orthopaed, EE-51014 Tartu, Estonia.
   [Loivukene, Krista] Tartu Univ Clin, Dept Clin Microbiol, United Labs, EE-50406 Tartu, Estonia.
C3 University of Tartu; University of Tartu; University of Tartu;
   University of Tartu
RP Mikelsaar, M (corresponding author), Univ Tartu, Fac Med, Dept Microbiol, Ravila 19, EE-50411 Tartu, Estonia.
EM marika.mikelsaar@ut.ee
RI Kolk, Helgi/AID-5582-2022; Sepp, Epp/H-6798-2015
OI Kolk, Helgi/0000-0001-7860-1082
FU Estonian Science Foundation [6782]; Ministry of Higher Education and
   Research [SF018255]
FX This study was supported by grants from the Estonian Science Foundation
   grant no. 6782 and the Ministry of Higher Education and Research (grant
   no. SF018255). We are thankful to Tiiu Kullisaar and medical students
   Piret Soovares and Liina Salusaar for their invaluable help in
   organizing the study. We appreciate the help from Irja Lutsar in
   preparation of the manuscript, the excellent statistical evaluation by
   Heti Pisarev and the technical assistance from Agnes Laasimer. We thank
   Zachary M. Gagnon for the English reading.
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NR 49
TC 31
Z9 33
U1 0
U2 17
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1075-9964
EI 1095-8274
J9 ANAEROBE
JI Anaerobe
PD JUN
PY 2010
VL 16
IS 3
BP 240
EP 246
DI 10.1016/j.anaerobe.2010.03.001
PG 7
WC Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Microbiology
GA 613AZ
UT WOS:000278949500013
PM 20223288
DA 2025-06-11
ER

PT J
AU Balázi, A
   Sirotkin, A
   Makovicky, P
   Chrastinová, L
   Makarevich, A
   Chrenek, P
AF Balazi, Andrei
   Sirotkin, Alexander, V
   Makovicky, Pavol
   Chrastinova, L'ubica
   Makarevich, Alexander
   Chrenek, Peter
TI Effect of Green Tea on Weight Gain and Semen Quality of Rabbit Males
SO VETERINARY SCIENCES
LA English
DT Article
DE rabbit male; sperm concentration and motility; testicular histology;
   weight gain
ID CAMELLIA-SINENSIS; OXIDATIVE STRESS; METABOLIC SYNDROME; EXTRACT; RATS;
   EPIGALLOCATECHIN-3-GALLATE; ANTIOXIDANT; PERFORMANCE; SUPPLEMENTS;
   POLYPHENOL
AB Simple Summary The consumption of green tea can reduce the occurrence of inflammatory and cardiovascular diseases, diabetes, cancer and obesity in humans. Due to its antioxidant and anti-microbial effects, green tea is considered an additive to feed in animal production to substitute for antibiotics. The goal of this study was to evaluate the action of the green tea plant (Camellia sinensis, L) given in powder form on male rabbits' reproductive functions (sperm concentration and motility, testicular morphology) and some non-reproductive traits (weight gain, blood metabolic/haematological and biochemical parameters). The obtained results demonstrate a reduction in rabbit weight gain, but deterioration of sperm quality under the influence of green tea feeding. This study suggests that green tea can affect the metabolic and reproductive systems of rabbit males in different manners, which should be taken into account when assessing the impact of green tea on a living organism. The goal of the current study was to evaluate the action of the green tea plant (Camellia sinensis, L) on male rabbit reproduction and some non-reproductive indexes. Male rabbits were fed either a standard diet (control group) or a diet enriched with green tea powder (experimental groups; E): 5 g (E1) or 20 g (E2) per 100 kg of the milled complete feed mixture. Weight gain, sperm concentration, total and progressive motility, as well as haematological, and biochemical parameters and changes in testicular tissue histomorphology were evaluated. Feeding with green tea, at both tested concentrations, decreased weight gain per week and the total average weight gain compared to the control group (p < 0.05). Furthermore, green tea decreased sperm concentration, motility and progressive motility in the group fed with a lower dose (5 g) of green tea powder (p < 0.05), whilst a higher dose (20 g) was neutral. Some haematological and biochemical indexes, like medium-size cell count (MID), mean corpuscular haemoglobin concentration (MCHC), platelet percentage (PCT), levels of phosphorus (P) and total proteins (TP) were decreased in one or both experimental groups (p < 0.05), whilst the triglyceride level (TG) was increased in the E2 group (p < 0.05). The thicknesses of the testicular seminiferous tubules and epithelial layer were not affected by any concentration of green tea powder (p > 0.05). These observations suggest that green tea in the diet may have an adverse effect on rabbit growth and sperm quality, but their effect may be potentially dose-dependent.
C1 [Balazi, Andrei; Chrastinova, L'ubica; Makarevich, Alexander; Chrenek, Peter] NPPC, Res Inst Anim Prod Nitra, Inst Farm Anim Genet & Reprod, Hlohovecka 2, Luzianky 95141, Slovakia.
   [Sirotkin, Alexander, V] Constantine Philosopher Univ Nitra, Dept Zool & Anthropol, Nabrezie Mladeze 91, Nitra 94901, Slovakia.
   [Makovicky, Pavol] J Selye Univ, Fac Educ, Dept Biol, Bratislava 94501, Slovakia.
   [Chrenek, Peter] Slovak Univ Agr, Fac Biotechnol & Food Sci, Inst Biotechnol, Tr A Hlinku 2, Nitra 94976, Slovakia.
C3 Constantine the Philosopher University in Nitra; J. Selye University;
   Comenius University Bratislava; Slovak University of Agriculture Nitra
RP Balázi, A; Chrenek, P (corresponding author), NPPC, Res Inst Anim Prod Nitra, Inst Farm Anim Genet & Reprod, Hlohovecka 2, Luzianky 95141, Slovakia.; Chrenek, P (corresponding author), Slovak Univ Agr, Fac Biotechnol & Food Sci, Inst Biotechnol, Tr A Hlinku 2, Nitra 94976, Slovakia.
EM andrej.balazi@nppc.sk; pavel.makovicky@gmail.cz;
   lubica.chrastinova@nppc.sk; alexander.makarevic@nppc.sk;
   peter.chrenek@uniag.sk
RI Chrenek, Peter/S-8273-2019; Makarevich, Alexander/HMV-5589-2023; Baláži,
   Andrej/HKN-7357-2023; Sirotkin, Alexander/U-3466-2017
OI Sirotkin, Alexander/0000-0001-9364-3512; Balazi,
   Andrej/0000-0003-0303-4794
FU Slovak Research and Development Agency (APVV) [APVV-17-0124,
   APVV-20-0006]; Slovak Grant Agency of the Ministry of Education, Science
   and Sport; Slovak Academy of Science (VEGA) [VEGA 1/0392/17, VEGA
   1/0049/19]
FX This work was supported by the Slovak Research and Development Agency
   (APVV) under the contracts APVV-17-0124, APVV-20-0006 and by the Slovak
   Grant Agency of the Ministry of Education, Science and Sport and the
   Slovak Academy of Science (VEGA), project VEGA 1/0392/17 and VEGA
   1/0049/19.
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NR 60
TC 1
Z9 1
U1 5
U2 9
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2306-7381
J9 VET SCI
JI Vet. Sci.
PD JUL
PY 2022
VL 9
IS 7
AR 321
DI 10.3390/vetsci9070321
PG 14
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA 3H8QW
UT WOS:000832296200001
PM 35878338
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Gardner, AW
   Parker, DE
   Montgomery, PS
AF Gardner, Andrew W.
   Parker, Donald E.
   Montgomery, Polly S.
TI Changes in vascular and inflammatory biomarkers after exercise
   rehabilitation in patients with symptomatic peripheral artery disease
SO JOURNAL OF VASCULAR SURGERY
LA English
DT Article
DE Angiogenesis; Antioxidant capacity; Claudication; Endothelial cell
   apoptosis; Exercise; Inflammation
ID ENDOTHELIAL GROWTH-FACTOR; OXIDATIVE STRESS; INTERMITTENT CLAUDICATION;
   ANTIOXIDANT CAPACITY; FUNCTIONAL DECLINE; METABOLIC SYNDROME;
   RISK-FACTORS; D-DIMER; MARKERS; WALKING
AB Objective: Home-based exercise is an alternative exercise mode to a structured supervised program to improve symptoms in patients with peripheral artery disease (PAD), but little is known about whether the slow-paced and less intense home program also elicits changes in vascular and inflammatory biomarkers. In an exploratory analysis from a randomized controlled trial, we compared changes in vascular and inflammatory biomarkers in patients with symptomatic PAD (typical and atypical of claudication) after home-based exercise and supervised exercise programs and in an attention-control group.
   Methods: A total of 114 patients were randomized into one of the three groups (n = 38 per group). Two groups performed exercise interventions, consisting of home-based and supervised programs of intermittent walking to mild to moderate claudication pain for 12 weeks; a third group performed light resistance training as a nonwalking attention-control group. Before and after intervention, patients were characterized on treadmill performance and endothelial effects of circulating factors present in sera by a cell culture-based bioassay on primary human arterial endothelial cells, and they were further evaluated on circulating vascular and inflammatory biomarkers.
   Results: Treadmill peak walking time increased (P = .008) in the two exercise groups but not in the control group (P > .05). Cultured endothelial cell apoptosis decreased after home-based exercise (P < .001) and supervised exercise (P = .007), and the change in the exercise groups combined was different from that in the control group (P = .005). For circulating biomarkers, increases were found in hydroxyl radical antioxidant capacity (P = .003) and vascular endothelial growth factor A (P = .037), and decreases were observed in E-selectin (P = .007) and blood glucose concentration (P = .012) after home-based exercise only. The changes in hydroxyl radical antioxidant capacity (P = .005), vascular endothelial growth factor A (P = .008), and E-selectin (P = .034) in the exercise groups combined were different from those in the control group.
   Conclusions: This exploratory analysis found that both home-based and supervised exercise programs are efficacious to decrease cultured endothelial cell apoptosis in patients with symptomatic PAD. Furthermore, a monitored home-based exercise program elicits additional vascular benefits by improving circulating markers of endogenous antioxidant capacity, angiogenesis, endothelium-derived inflammation, and blood glucose concentration in patients with symptomatic PAD. The novel clinical significance is that important trends were found in this exploratory analysis that a contemporary home-based exercise program and a traditional supervised exercise program may favorably improve vascular and inflammatory biomarkers in addition to the well-described ambulatory improvements in symptomatic patients with PAD.
C1 [Gardner, Andrew W.; Montgomery, Polly S.] Penn State Coll Med, Dept Phys Med & Rehabil, Hershey, PA USA.
   [Parker, Donald E.] Univ Oklahoma, Hlth Sci Ctr, Dept Biostat & Epidemiol, Oklahoma City, OK USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE);
   Pennsylvania State University; Penn State Health; University of Oklahoma
   System; University of Oklahoma Health Sciences Center
RP Gardner, AW (corresponding author), Penn State Coll Med, Dept PM&R, Res, 500 Univ Dr,POB 850,Mail Code HP28, Hershey, PA 17033 USA.
EM agardner4@pennstatehealth.psu.edu
FU National Institute on Aging [R01-AG-24296]; General Clinical Research
   Center [M01-RR-14467]
FX Supported by grants from the National Institute on Aging (R01-AG-24296)
   and General Clinical Research Center (M01-RR-14467).
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NR 39
TC 26
Z9 29
U1 1
U2 7
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0741-5214
J9 J VASC SURG
JI J. Vasc. Surg.
PD OCT
PY 2019
VL 70
IS 4
BP 1280
EP 1290
DI 10.1016/j.jvs.2018.12.056
PG 11
WC Surgery; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Surgery; Cardiovascular System & Cardiology
GA IY8AA
UT WOS:000486615200037
PM 30922751
OA Bronze, Green Accepted
DA 2025-06-11
ER

PT J
AU Yakovenko, A
   Cameron, M
   Trevino, JG
AF Yakovenko, Anastasiya
   Cameron, Miles
   Trevino, Jose Gilberto
TI Molecular therapeutic strategies targeting pancreatic cancer induced
   cachexia
SO WORLD JOURNAL OF GASTROINTESTINAL SURGERY
LA English
DT Review
DE Cachexia; Muscle wasting; Pancreatic cancer; Cachexia therapies;
   Molecular signaling
ID NECROSIS-FACTOR-ALPHA; POLYUNSATURATED FATTY-ACIDS; CELL LUNG-CANCER;
   DOUBLE-BLIND; SERUM-LEVELS; PHASE-II; PLACEBO; GEMCITABINE; COMBINATION;
   ANAMORELIN
AB Pancreatic cancer (PC) induced cachexia is a complex metabolic syndrome associated with significantly increased morbidity and mortality and reduced quality of life. The pathophysiology of cachexia is complex and poorly understood. Many molecular signaling pathways are involved in PC and cachexia. Though our understanding of cancer cachexia is growing, therapeutic options remain limited. Thus, further discovery and investigation of the molecular signaling pathways involved in the pathophysiology of cachexia can be applied to development of targeted therapies. This review focuses on three main pathophysiologic processes implicated in the development and progression of cachexia in PC, as well as their utility in the discovery of novel targeted therapies.
   Skeletal muscle wasting is the most prominent pathophysiologic anomaly in cachectic patients and driven by multiple regulatory pathways. Several known molecular pathways that mediate muscle wasting and cachexia include transforming growth factor-beta (TGF-beta), myostatin and activin, IGF-1/PI3K/AKT, and JAK-STAT signaling. TGF-beta antagonism in cachectic mice reduces skeletal muscle catabolism and weight loss, while improving overall survival. Myostatin/activin inhibition has a great therapeutic potential since it plays an essential role in skeletal muscle regulation. Overexpression of insulin-like growth factor binding protein-3 (IGFBP-3) leads to increased ubiquitination associated proteolysis, inhibition of myogenesis, and decreased muscle mass in PC induced cachexia. IGFBP-3 antagonism alleviates muscle cell wasting.
   Another component of cachexia is profound systemic inflammation driven by pro-cachectic cytokines such as interleukin-6 (IL-6), tumor necrosis factoralpha (TNF-alpha), and interferon gamma (INF-gamma). IL-6 antagonism has been shown to reduce inflammation, reduce skeletal muscle loss, and ameliorate cachexia. While TNF-alpha inhibitors are clinically available, blocking TNF-alpha signaling is not effective in the treatment of cancer cachexia. Blocking the synthesis or action of acute phase reactants and cytokines is a feasible therapeutic strategy, but no anti-cytokine therapies are currently approved for use in PC. Metabolic alterations such as increased energy expenditure and gluconeogenesis, insulin resistance, fat tissue browning, excessive oxidative stress, and proteolysis with amino acid mobilization support tumor growth and the development of cachexia. Current innovative nutritional strategies for cachexia management include ketogenic diet, utilization of natural compounds such as silibinin, and supplementation with.3-polyunsaturated fatty acids. Elevated ketone bodies exhibit an anticancer and anticachectic effect. Silibinin has been shown to inhibit growth of PC cells, induce metabolic alterations, and reduce myofiber degradation. Consumption of omega 3-polyunsaturated fatty acids has been shown to significantly decrease resting energy expenditure and regulate metabolic dysfunction.
C1 [Yakovenko, Anastasiya; Cameron, Miles] Univ Florida, Coll Med, Gainesville, FL 32610 USA.
   [Trevino, Jose Gilberto] Univ Florida, Dept Surg, Hlth Sci Ctr, Gainesville, FL 32610 USA.
C3 State University System of Florida; University of Florida; State
   University System of Florida; University of Florida
RP Trevino, JG (corresponding author), Univ Florida, Coll Med, Dept Surg, 1600 SW Archer Rd,POB 100109, Gainesville, FL 32610 USA.
EM jose.trevino@surgery.ufl.edu
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NR 86
TC 40
Z9 44
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U2 9
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 7041 Koll Center Parkway, Suite 160, PLEASANTON, CA, UNITED STATES
SN 1948-9366
J9 WORLD J GASTRO SURG
JI World J. Gastrointest. Surg.
PD DEC 27
PY 2018
VL 10
IS 9
BP 95
EP 106
DI 10.4240/wjgs.v10.i9.95
PG 12
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA HG1GU
UT WOS:000454700900001
PM 30622678
OA Green Submitted, Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Bengmark, S
AF Bengmark, Stig
TI Obesity, the deadly quartet and the contribution of the neglected daily
   organ rest - a new dimension of un-health and its prevention
SO HEPATOBILIARY SURGERY AND NUTRITION
LA English
DT Review
DE Postprandial; hyperglycaemia; detoxification; organ rest; sleep
   deprivation
ID CIRCADIAN-RHYTHMS; SKELETAL-MUSCLE; ADIPOSE-TISSUE; METABOLIC SYNDROME;
   DIETARY PRACTICES; SHIFT WORK; DISEASE; INFLAMMATION; SLEEP; BURDEN
AB The "deadly quartet": excessive weight, hypertension, impaired glucose homeostasis, and atherogenic dyslipidemia constitute a greater threat to health than the added effects of smoking and alcohol abuse. It is strongly associated with unrestricted consumption of processed, refined foods. Recent observations from experience in South East Asia shows that the interval between lifestyle changes and associated change in disease pattern is shorter than earlier believed. Recent experience from obesity studies in Africa demonstrates not only dramatic changes in health but also large social consequences from being overweight. Obesity is not only a result of overeating - dozens of other factors are known to contribute. Our palaeolithic forefathers and those living a similar lifestyle today are reported to rarely have diseases and to live a long life. One such group is the Hunzas, living in Northern Pakistan, are reported to live on a daily 1,800-calorie 99% plant-based diet, consisting in 73% of mostly unrefined/unprocessed carbohydrates, 17% fat and 10% protein. They, and most likely also our forefathers, do/did most likely only eat twice a day, at noon and early evening. Calorie-restriction (CR) and also fasting was early recommended and has been so during thousands of years - early Greek medicine and giants such as Hippocrates, Galenus and later also Paracelsus prescribed restrictions in eating and fasting. So did Middle Age physicians and other nutrition experts such as Louis Cornado. Today it is again practiced around the World. Overeating and heavy postprandial metabolism is a great burden to the body causing elevated levels in blood of endotoxin, increased inflammatory and oxidative stress, release of tumor necrosis factor-alpha, and other pro-inflammatory cytokines, increases in numbers of and activating of leukocytes, a reaction that is potentiated by the presence of large-chain fatty acids and sugars. Various metabolic, uremic, microbiota-derived and environmental poisons accumulate in large amounts in the adipose tissues. High levels of poisons in the adipose tissues decreases the turnover of fats in order to protect other organs. The content in adipose of POPs - altogether 17 dioxins/furans and 18 polychlorinated biphenyl congeners, has been reported to be 2-3 times higher in obese compared to lean persons. Daily fasting consisting in 16 to 18 hours of avoidance of calorie intake offers an interesting alternative. An attractive policy is to abstain from eating between 18:00 in the evening and 10:00 or 12:00 AM, a plan, which I personally have practiced during many years.
C1 [Bengmark, Stig] UCL, Div Surg & Intervent Sci, London WC1E 6AU, England.
C3 University of London; University College London
RP Bengmark, S (corresponding author), 185 Barrier Point Rd,Pontoon Docks, London E16 2SE, England.
EM stig@bengmark.se
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NR 56
TC 6
Z9 6
U1 0
U2 16
PU AME PUBLISHING COMPANY
PI SHATIN
PA FLAT-RM C 16F, KINGS WING PLAZA 1, NO 3 KWAN ST, SHATIN, HONG KONG
   00000, PEOPLES R CHINA
SN 2304-3881
EI 2304-389X
J9 HEPATOBIL SURG NUTR
JI Hepatobil. Surg. Nutr.
PD AUG
PY 2015
VL 4
IS 4
BP 278
EP 288
DI 10.3978/j.issn.2304-3881.2015.07.02
PN 1
PG 11
WC Gastroenterology & Hepatology; Nutrition & Dietetics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Nutrition & Dietetics; Surgery
GA V70OX
UT WOS:000211517000006
PM 26312244
DA 2025-06-11
ER

PT J
AU Yuan, QM
   Zhou, XH
   Ma, L
   Cai, BY
   Zhang, ZL
   Deng, LH
   Hu, D
   Jiang, ZY
   Wang, MD
   Wei, Q
   Qiu, S
AF Yuan, Qiming
   Zhou, Xianghong
   Ma, Li
   Cai, Boyu
   Zhang, Zilong
   Deng, Linghu
   Hu, Dan
   Jiang, Zhongyuan
   Wang, Mingda
   Wei, Qiang
   Qiu, Shi
TI The Association Between Solid Fuel Use and Lower Urinary Tract Symptoms
   Suggestive of Benign Prostatic Hyperplasia in Sichuan, China:
   Cross-Sectional Study
SO JMIR PUBLIC HEALTH AND SURVEILLANCE
LA English
DT Article
DE benign prostatic hyperplasia; lower urinary tract symptoms; solid fuel;
   household air pollution; China; male; cohort study; prostate; aging;
   smoking; alcohol
ID OXIDATIVE STRESS; AIR-POLLUTION; TESTOSTERONE; HEALTH; EXPRESSION;
   EXPOSURE; OBESITY; CANCER
AB Background: Benign prostatic hyperplasia (BPH) is a global age-related disease. It has been reported that over half of the Chinese male population aged 70 years or older are experiencing BPH. Solid fuel, which is the major source of household air pollution, has been reportedly associated with several adverse events, including sex hormone disorders. Due to the certain relationship between sex hormone levels and prostate disease, the relationship between solid fuel use and lower urinary tract symptoms (LUTSs) suggestive of BPH (LUTS/BPH) deserves further exploration. Objective: This study mainly aimed to investigate the association between solid fuel use and LUTS/BPH. Methods: The data used in this study were obtained from the West China Natural Population Cohort Study. Household energy sources were assessed using questionnaires. LUTS/BPH was evaluated based on participant self-reports. We performed propensity score matching (PSM) to reduce the influence of bias and unmeasured confounders. The odds ratio (OR) and 95% CI of LUTS/BPH for the solid fuel group compared with the clean fuel group were calculated. We also conducted stratified analyses based on BMI, metabolic syndrome, waist to hip ratio, drinking status, smoking status, and age. Results: A total of 5463 participants were included in this study, including 399 solid fuel users and 5064 clean fuel users. After PSM, the solid fuel group included 354 participants, while the clean fuel group included 701 participants. Solid fuel use was positively correlated with LUTS/BPH before and after PSM (OR 1.68, 95% CI 1.31-2.15 and OR 1.81, 95% CI 1.35-2.44, respectively). In stratified analyses, the OR of the nonsmoking group was higher than that of the smoking group (OR 2.56, 95% CI 1.56-4.20 and OR 1.47, 95% CI 0.99-2.18, respectively). Similarly, the OR of the nondrinking group was higher than that of the drinking group (OR 2.70, 95% CI 1.46-4.99 and OR 1.48, 95% CI 1.01-2.17, respectively). Conclusions: A positive correlation between solid fuel use and LUTS/BPH was observed. The results suggest that improving fuel structure for household cooking and other household needs can possibly help reduce the risk of LUTS/BPH. Trial Registration: China Clinical Trial Registration Center ChiCTR1900024623; https://www.chictr.org.cn/showproj.html? proj=40590
C1 [Yuan, Qiming; Zhou, Xianghong; Cai, Boyu; Zhang, Zilong; Deng, Linghu; Wei, Qiang; Qiu, Shi] Sichuan Univ, West China Hosp, Dept Urol, Inst Urol,Natl Clin Res Ctr Geriatr, 37 Guoxue Alley, Chengdu 610041, Peoples R China.
   [Yuan, Qiming; Zhou, Xianghong; Cai, Boyu; Zhang, Zilong; Deng, Linghu; Wei, Qiang; Qiu, Shi] Sichuan Univ, Ctr Biomed Big Data, West China Hosp, 37 Guoxue Alley, Chengdu 610041, Peoples R China.
   [Ma, Li] Sichuan Univ, Inst Hosp Management, West China Hosp, West China Sch Nursing, Chengdu, Peoples R China.
   [Deng, Linghu] Ente Osped Cantonale, Labs Translat Res, Neurodegenerat Disorders Lab, Bellinzona, Switzerland.
   [Hu, Dan; Jiang, Zhongyuan; Wang, Mingda] Sichuan Univ, West China Hosp, Clin Res Dept, Chengdu, Peoples R China.
   [Qiu, Shi] Sichuan Univ, West China Hosp, Natl Clin Res Ctr Geriatr, Dept Urol,Inst Urol, 37 Guoxue Alley, Chengdu 610041, Sichuan, Peoples R China.
C3 Sichuan University; Sichuan University; Sichuan University; Sichuan
   University; Sichuan University
RP Qiu, S (corresponding author), Sichuan Univ, West China Hosp, Dept Urol, Inst Urol,Natl Clin Res Ctr Geriatr, 37 Guoxue Alley, Chengdu 610041, Peoples R China.; Qiu, S (corresponding author), Sichuan Univ, Ctr Biomed Big Data, West China Hosp, 37 Guoxue Alley, Chengdu 610041, Peoples R China.; Qiu, S (corresponding author), Sichuan Univ, West China Hosp, Natl Clin Res Ctr Geriatr, Dept Urol,Inst Urol, 37 Guoxue Alley, Chengdu 610041, Sichuan, Peoples R China.
EM qiushi@scu.edu.cn
RI ma, li/ABH-3350-2022; Jiang, Zhongyuan/B-3847-2012; Wang,
   Mingda/GRS-9652-2022; Deng, Linghui/HMV-6304-2023; Cai,
   Boyu/JMQ-4001-2023; HU, DANRONG/JQI-7308-2023
OI D, L/0000-0003-2153-6421; ma, li/0000-0003-0831-332X
FU National Natural Science Foundation of China [81974099, 82170785,
   81974098, 82170784]; Foundation of National Clinical Research Center for
   Geriatrics [Z2024LC003]; Science and Technology Department of Sichuan
   Province [21GJHZ0246]; Young Investigator Award of Sichuan University
   [2017SCU04A17]; Technology Innovation Research and Development Project
   of Chengdu Science and Technology Bureau [2019-YF05-00296-SN,
   2022-YF05-01884-SN]; Sichuan University-Panzhihua science and technology
   coopera-tion special fund [2020CDPZH-4]; Postdoctoral Fellowship Program
   of the Chinese Postdoctoral Science Foundation [GZC20241158]
FX This program was supported by the National Natural Science Foundation of
   China (grants 81974099, 82170785, 81974098, and 82170784) , Foundation
   of National Clinical Research Center for Geriatrics (Z2024LC003) ,
   programs from the Science and Technology Department of Sichuan Province
   (grant 21GJHZ0246) , Young Investigator Award of Sichuan University 2017
   (grant 2017SCU04A17) , Technology Innovation Research and Development
   Project of Chengdu Science and Technology Bureau (2019-YF05-00296-SN and
   2022-YF05-01884-SN) , Sichuan University-Panzhihua science and
   technology coopera-tion special fund (2020CDPZH-4) , and the
   Postdoctoral Fellowship Program of the Chinese Postdoctoral Science
   Foundation (GZC20241158) .
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NR 36
TC 0
Z9 0
U1 3
U2 8
PU JMIR PUBLICATIONS, INC
PI TORONTO
PA 130 QUEENS QUAY East, Unit 1100, TORONTO, ON M5A 0P6, CANADA
SN 2369-2960
J9 JMIR PUBLIC HLTH SUR
JI JMIR Public Health Surveill.
PY 2024
VL 10
AR e53673
DI 10.2196/53673
PG 12
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA M8B9M
UT WOS:001359742900001
PM 39481119
OA gold
DA 2025-06-11
ER

PT J
AU Banasiak, W
   Pociupany, R
   Wilkins, A
   Ponikowski, P
AF Banasiak, Waldemar
   Pociupany, Robert
   Wilkins, Arleta
   Ponikowski, Piotr
TI Characteristics of patients with coronary artery disease managed on an
   outpatient basis in the population of Poland. Results of the multicentre
   RECENT trial
SO KARDIOLOGIA POLSKA
LA English
DT Article
DE stable ischaemic heart disease; risk factors
ID ISCHEMIC-HEART-DISEASE; CLINICAL CHARACTERISTICS; STABLE ANGINA;
   GENDER-DIFFERENCES; EUROPEAN-SOCIETY; TASK-FORCE; PREVENTION; MORTALITY;
   CARDIOLOGY; BURDEN
AB Introduction: Comprehension of clinical characteristics and therapeutic methods in patients with coronary artery disease (CAD) is mandatory for the introduction of successful prevention.
   Aim: The aim of the multicentre RECENT trial carried out in Poland in 2005 was to gather comprehensive information regarding individuals with CAD treated by specialists as well as by general practitioners on an outpatient basis. In this report, clinical characteristics of the Polish patient population with confirmed CAD are presented.
   Methods: A representative group of 215 general practitioners and 67 specialists participated in this study. They collected information about 2593 patients with CAD and filled-in a specially designed questionnaire.
   Results: Coronary artery disease was confirmed predominantly based on a history of myocardial infarction (50.1%), followed by positive electrocardiographic stress test (38.8%), history of typical angina in subjects at the age of >60 years (36.4%), history of previous acute coronary syndrome (29.0%), PCI (22.1%) or CABG (14.3%) or positive coronary angiography (17.6%). In patients with diagnosed stable CAD, 44.6% were women and the mean age was 65.0+/-9.8 years. Among patients with a history of hypertension (78.0%), only 34.0% had blood pressure within the normal range. History of dyslipidaemia was positive in 57.6% of patients. Normal LDL cholesterol concentrations (6.36 mmol/L) were found in 56.7% of patients. A family history of CAD had 17.3% of subjects, 23.5% had previously detected diabetes mellitus and 11.0% were active smokers at the time of study enrolment. Overweight or obesity both in men and women was found in 79.3% of patients while metabolic syndrome (diagnosed according to NCEP ATP III criteria) was found in 31.3%. The following comorbidities were detected: 34.3% presented symptoms of congestive heart failure, 32.1% had rhythm or conduction disturbances (most commonly atrial fibrillation - in 19.0% of cases). Previous stroke was noted in 4.7% of patients with CAD and transient ischaemic attack in 5.5%. Peripheral artery disease was observed in 9.9% of CAD patients, whereas asthma or COPD - in 9.0%.
   Conclusions: The results of the RECENT trial are representative for the CAD patient population managed on an outpatient basis in our country. They suggest that CAD in the Polish population is rather advanced, and indicate still insufficient use of imaging modalities (particularly coronary angiography) and significant prevalence of risk factors throughout this population.
C1 [Banasiak, Waldemar; Ponikowski, Piotr] 4th Mil Clin Hosp, Heard Dis Ctr, Wroclaw, Poland.
   [Pociupany, Robert; Wilkins, Arleta] Servier Polska, Warsaw, Poland.
C3 Servier
RP Ponikowski, P (corresponding author), 4 Wojskowy Szpital Klin, Kardiol Klin, Osrodek Chorob Serca, Ul Weigla 5, PL-50089 Wroclaw, Poland.
EM piotrponikowski@4wsk.pl
RI Ponikowski, Piotr/O-6454-2015
OI Ponikowski, Piotr/0000-0002-3391-7064
CR [Anonymous], 2002, HEART DIS STROK STAT
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NR 28
TC 13
Z9 14
U1 0
U2 2
PU POLSKIE TOWARZYSTOWO KARDIOLOGICZNE
PI WARSZAWA
PA UL STAWKI 3 A LOK 1-2, WARSZAWA, POLAND
SN 0022-9032
EI 1897-4279
J9 KARDIOL POL
JI Kardiol. Pol.
PD FEB
PY 2007
VL 65
IS 2
BP 132
EP 138
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 281IH
UT WOS:000254489600007
PM 17366357
DA 2025-06-11
ER

PT J
AU Mironczuk, A
   Kapica-Topczewska, K
   Socha, K
   Soroczynska, J
   Jamiolkowski, J
   Chorazy, M
   Czarnowska, A
   Mitrosz, A
   Kulakowska, A
   Kochanowicz, J
AF Mironczuk, Anna
   Kapica-Topczewska, Katarzyna
   Socha, Katarzyna
   Soroczynska, Jolanta
   Jamiolkowski, Jacek
   Chorazy, Monika
   Czarnowska, Agata
   Mitrosz, Agnieszka
   Kulakowska, Alina
   Kochanowicz, Jan
TI Disturbed Ratios between Essential and Toxic Trace Elements as Potential
   Biomarkers of Acute Ischemic Stroke
SO NUTRIENTS
LA English
DT Article
DE essential trace elements; heavy metals; cadmium; lead; ischemic stroke;
   atherosclerosis
ID CADMIUM EXPOSURE; MALMO DIET; METABOLIC SYNDROME; US ADULTS; RISK; LEAD;
   ATHEROSCLEROSIS; MECHANISMS; MORTALITY; SMOKING
AB Background: Cadmium (Cd) and lead (Pb) are known to be two of the metal contaminants that pose the greatest potential threat to human health. The purpose of this research study was to compare the levels of toxic metals (Cd, Pb) in patients with acute ischemic stroke (AIS), with a control group in Podlaskie Voivodeship, Poland. The study also aimed to assess the correlations between toxic metals and clinical data in AIS patients, and to assess the potential effect of smoking. Materials and methods: The levels of mineral components in the collected blood samples were assessed by means of atomic absorption spectrometry (AAS). Results: The Cd blood concentration was significantly higher in AIS patients as compared to the control group. We found that the molar ratios of Cd/Zn and Cd/Pb were significantly higher (p < 0.001; p < 0.001, respectively), when the molar ratios of Se/Pb, Se/Cd, and Cu/Cd were significantly lower (p = 0.01; p < 0.001; p < 0.001, respectively), in AIS patients as compared to control subjects. However, there were no considerable fluctuations in relation to the blood Pb concentration or molar ratios of Zn/Pb and Cu/Pb between our AIS patients and the control group. We also found that patients with internal carotid artery (ICA) atherosclerosis, particularly those with 20-50% ICA stenosis, had higher concentrations of Cd and Cd/Zn, but lower Cu/Cd and Se/Cd molar ratios. In the course of our analysis, we observed that current smokers among AIS patients had significantly higher blood-Cd concentrations, Cd/Zn and Cd/Pb molar ratios, and hemoglobin levels, but significantly lower HDL-C concentrations, Se/Cd, and Cu/Cd molar ratios. Conclusions: Our research has shown that the disruption of the metal balance plays a crucial role in the pathogenesis of AIS. Furthermore, our results broaden those of previous studies on the exposure to Cd and Pb as risk factors for AIS. Further investigations are necessary to examine the probable mechanisms of Cd and Pb in the onset of ischemic stroke. The Cd/Zn molar ratio may be a useful biomarker of atherosclerosis in AIS patients. An accurate assessment of changes in the molar ratios of essential and toxic trace elements could serve as a valuable indicator of the nutritional status and levels of oxidative stress in AIS patients. It is critical to investigate the potential role of exposure to metal mixtures in AIS, due to its public health implications.
C1 [Mironczuk, Anna; Kapica-Topczewska, Katarzyna; Chorazy, Monika; Czarnowska, Agata; Mitrosz, Agnieszka; Kulakowska, Alina; Kochanowicz, Jan] Med Univ Bialystok, Dept Neurol, M Sklodowskiej Curie 24a St, PL-15276 Bialystok, Poland.
   [Socha, Katarzyna; Soroczynska, Jolanta] Med Univ Bialystok, Fac Pharm, Dept Bromatol, Div Lab Med, Mickiewicza 2D St, PL-15222 Bialystok, Poland.
   [Jamiolkowski, Jacek] Med Univ Bialystok, Dept Populat Med & Lifestyle Dis Prevent, M Sklodowskiej Curie 24a St, PL-15276 Bialystok, Poland.
C3 Medical University of Bialystok; Medical University of Bialystok;
   Medical University of Bialystok
RP Mironczuk, A (corresponding author), Med Univ Bialystok, Dept Neurol, M Sklodowskiej Curie 24a St, PL-15276 Bialystok, Poland.
EM anna-mironczuk@wp.pl
RI Kochanowicz, Jan/AAI-6412-2020; Jamiolkowski, Jacek/T-6324-2018;
   Chorazy, Monika/ABI-6365-2020; kapica-topczewska,
   katarzyna/ABD-9114-2020
OI Mironczuk, Anna/0000-0001-9624-6299; Czarnowska,
   Agata/0000-0003-2920-1271; Socha, Katarzyna/0000-0002-5949-7061
FU Medical University of Bialystok (Poland) [SUB/1/DN/22/002/1144]
FX This work was supported by the Medical University of Bialystok (Poland),
   grant number SUB/1/DN/22/002/1144. The funders had no role in data
   collection and analysis, study design, preparation of the manuscript or
   decision to publish. All authors had full open access at all stages to
   all the data in the study and had final responsibility for the decision
   to submit for publication.
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NR 114
TC 7
Z9 7
U1 0
U2 5
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD MAR
PY 2023
VL 15
IS 6
AR 1434
DI 10.3390/nu15061434
PG 21
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA A9WK4
UT WOS:000958545300001
PM 36986164
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Furlong, MA
   Klimentidis, YC
AF Furlong, Melissa A.
   Klimentidis, Yann C.
TI Associations of air pollution with obesity and body fat percentage, and
   modification by polygenic risk score for BMI in the UK Biobank
SO ENVIRONMENTAL RESEARCH
LA English
DT Article
DE Air pollution; Obesity; BMI; Gene by environment interactions;
   Epidemiology
ID FINE PARTICULATE MATTER; LONG-TERM EXPOSURE; OXIDATIVE STRESS;
   INSULIN-RESISTANCE; CIGARETTE-SMOKING; TRAFFIC NOISE; MASS INDEX;
   RESIDENTIAL PROXIMITY; METABOLIC SYNDROME; DNA METHYLATION
AB Air pollution has consistently been associated with cardiometabolic outcomes, although associations with obesity have only been recently reported. Studies of air pollution and adiposity have mostly relied on body mass index (BMI) rather than body fat percentage (BF%), and most have not accounted for noise as a possible confounder. Additionally, it is unknown whether genetic predisposition for obesity increases susceptibility to the obesogenic effects of air pollution. To help fill these gaps, we used the UK Biobank, a large, prospective cohort study in the United Kingdom, to explore the relationship between air pollution and adiposity, and modification by a polygenic risk score for BMI. We used 2010 annual averages of air pollution estimates from land use regression (NO2, NOX, PM2.5, PM2.5absorbance, PM2.5-10, PM10), traffic intensity (TI), inverse distance to road (IDTR), along with examiner-measured BMI, waist-hip-ratio (WHR), and impedance measures of BF%, which were collected at enrollment (2006-2010, n = 473,026) and at follow-up (2012-2013, n = 19,518). We estimated associations of air pollution with BMI, WHR, and BF% at enrollment and follow-up, and with obesity, abdominal obesity, and BF%-obesity at enrollment and follow-up. We used linear and logistic regression and controlled for noise and other covariates. We also assessed interactions of air pollution with a polygenic risk score for BMI. On average, participants at enrollment were 56 years of age, 54% were female, and 32% had completed college or a higher degree. Almost all participants (similar to 95%) were white. All air pollution measures except IDTR were positively associated with at least one continuous measure of adiposity at enrollment. However, NO2 was negatively associated with BMI but positively associated with WHR at enrollment, and IDTR was also negatively associated with BMI. At follow-up (controlling for enrollment adiposity), we observed positive associations for PM2.5-10 with BMI, PM10 with BF%, and TI with BF% and BMI. Associations were similar for binary measures of adiposity, with minor differences for some pollutants. Associations of NOX, NO2, PM2.5absorbance, PM2.5 and PM10, with BMI at enrollment, but not at follow-up, were stronger among individuals with higher BMI polygenic risk scores (interaction p < 0.05). In this large, prospective cohort, air pollution was associated with several measures of adiposity at enrollment and follow-up, and associations with adiposity at enrollment were modified by a polygenic risk score for obesity.
C1 [Furlong, Melissa A.] Univ Arizona, Mel & Enid Zuckerman Coll Publ Hlth, Dept Commun Environm & Policy, Div Environm Hlth Sci, Tucson, AZ 85721 USA.
   [Klimentidis, Yann C.] Univ Arizona, Mel & Enid Zuckerman Coll Publ Hlth, Dept Epidemiol & Biostat, Tucson, AZ 85721 USA.
C3 University of Arizona; University of Arizona
RP Furlong, MA (corresponding author), 1656 E Mabel St, Tucson, AZ 85724 USA.
EM mfurlong@email.arizona.edu
RI Klimentidis, Yann/B-2348-2015
OI Klimentidis, Yann/0000-0002-6065-4044
FU United States National Heart, Lung, and Blood Institute [R01-HL136528];
   United States National Institute of Environmental Health Sciences
   [K99ES028743]
FX This project was supported by funding from the United States National
   Heart, Lung, and Blood Institute R01-HL136528, and by funding from the
   United States National Institute of Environmental Health Sciences
   K99ES028743 (MF).
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NR 77
TC 70
Z9 72
U1 6
U2 36
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0013-9351
EI 1096-0953
J9 ENVIRON RES
JI Environ. Res.
PD JUN
PY 2020
VL 185
AR 109364
DI 10.1016/j.envres.2020.109364
PG 8
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA LJ2YB
UT WOS:000530034100015
PM 32247148
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Takeuchi, M
   Sakasai-Sakai, A
   Takata, T
   Ueda, T
   Takino, J
   Tsutsumi, M
   Hyogo, H
   Yamagishi, S
AF Takeuchi, M.
   Sakasai-Sakai, A.
   Takata, T.
   Ueda, T.
   Takino, J.
   Tsutsumi, M.
   Hyogo, H.
   Yamagishi, S.
TI Serum levels of toxic AGEs (TAGE) may be a promising novel biomarker in
   development and progression of NASH
SO MEDICAL HYPOTHESES
LA English
DT Article
ID FATTY LIVER-DISEASE; GLYCATION END-PRODUCTS; GAMMA-GLUTAMYL-TRANSFERASE;
   DIABETIC VASCULAR COMPLICATIONS; HEPATOCELLULAR-CARCINOMA; NONALCOHOLIC
   STEATOHEPATITIS; ALZHEIMERS-DISEASE; FRUCTOSE CONSUMPTION; POLYOL
   PATHWAY; INVOLVEMENT
AB Nonalcoholic fatty liver disease (NAFLD) ranges from simple steatosis to nonalcoholic steatohepatitis (NASH), leads to fibrosis and potentially cirrhosis, liver failure, and hepatocellular carcinoma, and is one of the most common causes of liver disease worldwide. NAFLD has also been implicated in other medical conditions such as insulin resistance, obesity, metabolic syndrome, hyperlipemia, hypertension, cardiovascular disease, and diabetes. Continuous hyperglycemia has been implicated in the pathogenesis of diabetic micro- and macro-vascular complications via various metabolic pathways, and numerous hyperglycemia-induced metabolic and hemodynamic conditions exist, including the increased generation of various types of advanced glycation end-products (AGEs). We recently demonstrated that glyceraldehyde-derived AGEs (Glycer-AGEs), the predominant components of toxic AGEs (TAGE), played an important role in the pathogenesis of angiopathy in diabetic patients. Moreover, a growing body of evidence suggests that the interaction between TAGE and the receptor for AGEs may alter intracellular signaling, gene expression, and the release of pro-inflammatory molecules and also elicits the generation of oxidative stress in numerous types of cells including hepatocytes and hepatic stellate cells. Serum levels of TAGE were significantly higher in NASH patients than in those with simple steatosis and healthy controls. Moreover, serum levels of TAGE inversely correlated with adiponectin (adiponectin is produced by adipose tissue and is an anti-inflammatory adipokine that can increase insulin sensitivity). Furthermore, immunohistochemical staining of TAGE showed intense staining in the livers of patients with NASH. Serum levels of TAGE may be a useful biomarker for discriminating NASH from simple steatosis. The administration of atorvastatin (10 mg daily) for 12 months significantly improved NASH-related metabolic parameters and significantly decreased serum levels of TAGE. The steatosis grade and NAFLD activity score were also significantly improved. These results demonstrated that atorvastatin decreased the serum levels of TAGE in NASH patients with dyslipidemia and suggest the usefulness of TAGE as a biomarker for the attenuation of NASH. Serum levels of TAGE were significantly higher in non-B or non-C hepatocellular carcinoma (NBNC-HCC) patients than in NASH subjects without HCC or control subjects. TAGE may be involved in the pathogenesis of NBNC-HCC, and could, therefore, be a biomarker that could discriminate NBNC-HCC from NASH. We propose that serum levels of TAGE are promising novel targets for the diagnosis of and therapeutic interventions against NASH. (C) 2015 The Author. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
C1 [Takeuchi, M.; Sakasai-Sakai, A.; Takata, T.; Ueda, T.] Kanazawa Med Univ, Med Res Inst, Dept Adv Med, Uchinada, Ishikawa 9200293, Japan.
   [Takino, J.] Hiroshima Int Univ, Fac Pharmaceut Sci, Lab Biochem, Hiroshima, Japan.
   [Tsutsumi, M.] Kanazawa Med Univ, Dept Hepatol, Kanazawa, Ishikawa, Japan.
   [Hyogo, H.] Hiroshima Univ Hosp, Dept Gastroenterol & Metab, Hiroshima, Japan.
   [Yamagishi, S.] Kurume Univ, Sch Med, Dept Pathophysiol & Therapeut Diabet Vasc Complic, Fukuoka, Japan.
C3 Kanazawa Medical University; Kanazawa Medical University; Hiroshima
   University; Kurume University
RP Takeuchi, M (corresponding author), Kanazawa Med Univ, Med Res Inst, Dept Adv Med, Uchinada, Ishikawa 9200293, Japan.
EM takeuchi@kanazawa-med.ac.jp
RI Sakai-Sakasai, Akiko/AAC-9814-2020
OI Sakai-Sakasai, Akiko/0000-0002-1258-1725
FU JSPS KAKENHI [19300254, 22300264, 25282029]; Kanazawa Medical University
   [SR2012-04]; MEXT; Grants-in-Aid for Scientific Research [22300264,
   25282029, 19300254] Funding Source: KAKEN
FX This work was supported in part by JSPS KAKENHI Grant Nos. 19300254,
   22300264, & 25282029 (for Takeuchi), by Grant No. SR2012-04 (for
   Tsutsumi) for research from Kanazawa Medical University, and by MEXT:
   Regional Innovation Strategy Support Program (for Takeuchi).
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NR 45
TC 21
Z9 23
U1 1
U2 16
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0306-9877
EI 1532-2777
J9 MED HYPOTHESES
JI Med. Hypotheses
PD MAY
PY 2015
VL 84
IS 5
BP 490
EP 493
DI 10.1016/j.mehy.2015.02.002
PG 4
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA CF6NH
UT WOS:000352672900017
PM 25697114
OA hybrid
DA 2025-06-11
ER

PT J
AU Hoyer, S
   Riis, AH
   Toft, G
   Wise, LA
   Hatch, EE
   Wesselink, AK
   Rothman, KJ
   Sorensen, HT
   Mikkelsen, EM
AF Hoyer, S.
   Riis, A. H.
   Toft, G.
   Wise, L. A.
   Hatch, E. E.
   Wesselink, A. K.
   Rothman, K. J.
   Sorensen, H. T.
   Mikkelsen, E. M.
TI Male alcohol consumption and fecundability
SO HUMAN REPRODUCTION
LA English
DT Article
DE alcohol; fecundability; time to pregnancy; male fertility; infertility
ID MALE REPRODUCTIVE FUNCTION; CIGARETTE-SMOKING; PHYSICAL-ACTIVITY;
   SELECTION BIAS; SEMEN QUALITY; INFERTILITY; PREGNANCY; COHORT; TIME;
   EPIDEMIOLOGY
AB STUDY QUESTION: Does male alcohol consumption affect fecundability?
   SUMMARY ANSWER: In data pooled across Danish and North American preconception cohort studies, we found little evidence of an association between male alcohol consumption and reduced fecundability.
   WHAT IS KNOWN ALREADY: Experimental and clinical studies have shown that alcohol affects male reproductive physiology, mainly by altering male reproductive hormones and spermatogenesis. However, few epidemiologic studies have examined the association between alcohol consumption and male fertility.
   STUDY DESIGN, SIZE, DURATION: Data were collected from two ongoing prospective preconception cohort studies: the Danish 'SnartForaeldre' (SF) study (662 couples) and the North American 'Pregnancy Study Online' (PRESTO) (2017 couples). Participants included in the current analysis were enrolled from August 2011 through June 2019 (SF) and from June 2013 through June 2019 (PRESTO).
   PARTICIPANTS/MATERIALS, SETTING, METHODS: Eligible men were aged >= 18 years in SF and >= 21 years in PRESTO, in a stable relationship with a female partner and not using contraception or receiving fertility treatment. In both cohorts, alcohol consumption/serving size was self-reported as number of beers (330 mL/12 oz.), glasses of white or red wine (120 mL/4 oz. each), dessert wine (50 mL/2 oz.) and spirits (20 mL/1.5 oz.). Overall alcohol consumption was categorized as none, 1-5, 6-13 and >= 14 standard servings per week. Total menstrual cycles at risk were calculated using data from female partners' follow-up questionnaires, which were completed every 8 weeks until self-reported pregnancy or 12 menstrual cycles, whichever came first. Analyses were restricted to couples that had been trying to conceive for <= 6 cycles at study entry. Proportional probability regression models were used to compute fecundability ratios (FRs) and 95% confidence interval (CIs). We adjusted for male and female age, female partner's alcohol consumption, intercourse frequency, previous history of fathering a child, race/ethnicity, education, BMI, smoking and consumption of sugar-sweetened beverages and caffeine.
   MAIN RESULTS AND THE ROLE OF CHANCE: The cumulative proportion of couples who conceived during 12 cycles of follow-up were 1727 (64.5%). The median (interquartile range) of total male alcohol consumption was 4.5 (2.0-7.8) and 4.1 (1.0-8.6) standard servings per week in the SF and PRESTO cohorts, respectively. In pooled analyses, adjusted FRs for male alcohol consumption of 1-5, 6-13 and >= 14 standard servings per week compared with no alcohol consumption >= 14 standard servings per week compared with no alcohol consumption were 0.97 (95% CI: 0.73-1.28), 0.81 (95% CI: 0.60-1.10) and 0.82 (95% CI: 0.51-1.30), respectively. For PRESTO, adjusted FRs of 1-5, 6-13 and >= 14 standard servings per week compared with no alcohol consumption were 1.02 (95% CI: 0.88-1.18), 1.20 (95% CI: 1.03-1.40) and 1.03 (95% CI: 0.84-1.26), respectively.
   LIMITATIONS, REASONS FOR CAUTION: Male alcohol consumption was ascertained at baseline only, and we did not distinguish between regular and binge drinking. In addition, we had insufficient numbers to study the effects of specific types of alcoholic beverages. As always, residual confounding by unmeasured factors, such as dietary factors and mental health, cannot be ruled out. Comorbidities thought to play a role in the reproductive setting (i.e. cancer, metabolic syndrome) were not considered in this study; however, the prevalence of cancer and diabetes was low in this age group. Findings for the highest categories of alcohol consumption (6-13 and >= 14 servings/week) were not consistent across the two cohorts.
   WIDER IMPLICATIONS OF THE FINDINGS: Despite little evidence of an association between male alcohol consumption and reduced fecundability in the pooled analysis, data from the Danish cohort might indicate a weak association between reduced fecundability and consumption of six or more servings per week.
C1 [Hoyer, S.; Riis, A. H.; Toft, G.; Rothman, K. J.; Sorensen, H. T.; Mikkelsen, E. M.] Aarhus Univ Hosp, Dept Clin Epidemiol, DK-8200 Aarhus N, Denmark.
   [Wise, L. A.; Hatch, E. E.; Wesselink, A. K.; Rothman, K. J.; Sorensen, H. T.] Boston Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA USA.
   [Rothman, K. J.] RTI Hlth Solut, Res Triangle Pk, NC 27709 USA.
C3 Aarhus University; Boston University; Research Triangle Institute
RP Hoyer, S (corresponding author), Dept Clin Epidemiol, Olof Palmes 43-45, DK-8200 Aarhus N, Denmark.
EM sidse.hoeyer@hotmail.com
RI Sørensen, Henrik/Z-6181-2019
OI Riis, Anders Hammerich/0000-0002-6684-4068; Hoyer,
   Sidse/0000-0002-1477-5400; Toft, Gunnar/0000-0002-7542-6853; Toft
   Sorensen, Henrik/0000-0003-4299-7040
FU National Institutes of Health [R01-HD060680, R01-HD086742, R21-HD050264,
   R21-HD072326, R03-HD090315]; Novo Nordisk Foundation; Oticon Fonden;
   Politimester J.P.N. Colind og hustru Asmine Colinds mindelegat; Erna og
   Peter Houtveds studielegat
FX This study was supported by the National Institutes of Health
   (R01-HD060680, R01HD086742, R21-HD050264, R21-HD072326, R03-HD090315),
   the Novo Nordisk Foundation, Oticon Fonden, Politimester J.P.N. Colind
   og hustru Asmine Colinds mindelegat and Erna og Peter Houtveds
   studielegat. PRESTO receives in-kind donations from FertilityFriend.com,
   Kindara.com, Swiss Precision Diagnostics and Sandstone Diagnostics for
   the collection of data pertaining to fertility.This study was supported
   by the National Institutes of Health (R01-HD060680, R01HD086742,
   R21-HD050264, R21-HD072326, R03-HD090315), the Novo Nordisk Foundation,
   Oticon Fonden, Politimester J.P.N. Colind og hustru Asmine Colinds
   mindelegat and Erna og Peter Houtveds studielegat. PRESTO receives
   in-kind donations from FertilityFriend.com, Kindara.com, Swiss Precision
   Diagnostics and Sandstone Diagnostics for the collection of data
   pertaining to fertility. Dr Wise serves as a consultant on uterine
   leiomyomata for AbbVie.com. All other authors declare no conflict of
   interest.
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NR 52
TC 11
Z9 11
U1 2
U2 17
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0268-1161
EI 1460-2350
J9 HUM REPROD
JI Hum. Reprod.
PD APR
PY 2020
VL 35
IS 4
BP 816
EP 825
DI 10.1093/humrep/dez294
PG 10
WC Obstetrics & Gynecology; Reproductive Biology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Obstetrics & Gynecology; Reproductive Biology
GA NN8PV
UT WOS:000569049800009
PM 32155263
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Bugiardini, R
   Merz, CNB
AF Bugiardini, R
   Merz, CNB
TI Angina with "normal" coronary arteries a changing philosophy
SO JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
LA English
DT Review
ID CARDIAC SYNDROME-X; LONG-TERM PROGNOSIS; CHEST-PAIN; ENDOTHELIAL
   FUNCTION; MYOCARDIAL-ISCHEMIA; NITRIC-OXIDE; CLINICAL CHARACTERISTICS;
   MICROVASCULAR FUNCTION; OXIDATIVE STRESS; NATIONAL-HEART
AB Context Many women with angina are told that they have no significant heart disease following demonstration of normal or near-normal coronary arteries and are offered no specific treatment beyond reassurance.
   Evidence Acquisition MEDLINE and the Cochrane Database of Systematic Reviews were searched from their start dates until June 2004 for analysis using specific key words including diagnosis and therapy of angina with normal angiography and angina with normal coronary arteries. Reference list of published articles and data of meeting presentations were also consulted.
   Evidence Synthesis Normal or nonobstructive coronary disease at angiography is not uncommon and occurs in 10% of women presenting with ST-segment elevation myocardial infarction compared with 6% in men. Patients with evidence of myocardial ischemia or myocardial infarction and nonobstructive atherosclerotic disease of the coronary arteries are more likely to be women and nonwhite. Symptoms are often indistinguishable from those with obstructive coronary artery disease. The prognosis of patients with unstable angina and nonobstructive atherosclerotic coronary artery disease is not benign and includes a 2% risk of death or myocardial infarction at 30 days of follow-up. Recent work has shown that at least 20% of women with normal or nonobstructive angiography have myocardial ischemia. likely due to atherosclerosis-related endothelial dysfunction, which itself is associated with an increased risk of later adverse cardiac events and development of frank future obstructive disease. Randomized placebo-controlled studies have demonstrated that tricyclic antidepressants, beta-blockers, angiotensin-converting enzyme inhibitors, L-arginine, statins, and exercise may relieve symptoms, vascular dysfunction, or both; however, longer-term studies evaluating cardiac event rates need to be performed.
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C1 Univ Bologna, Dept Internal Med Cardioangiol & Hepatol, I-40138 Bologna, Italy.
   Univ Calif Los Angeles, Sch Med, Cedars Sinai Med Ctr, Dept Med,Div Cardiol, Los Angeles, CA USA.
C3 University of Bologna; Cedars Sinai Medical Center; University of
   California System; University of California Los Angeles; University of
   California Los Angeles Medical Center; David Geffen School of Medicine
   at UCLA
RP Univ Bologna, Dept Internal Med Cardioangiol & Hepatol, Padiglione 11,Via Massarenti 9, I-40138 Bologna, Italy.
EM raffaele.bugiardini@unibo.it
RI Bugiardini, Raffaele/L-6446-2015
OI Bugiardini, Raffaele/0000-0002-6819-6818
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NR 78
TC 425
Z9 438
U1 3
U2 16
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 0098-7484
EI 1538-3598
J9 JAMA-J AM MED ASSOC
JI JAMA-J. Am. Med. Assoc.
PD JAN 26
PY 2005
VL 293
IS 4
BP 477
EP 484
DI 10.1001/jama.293.4.477
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 890DW
UT WOS:000226492900027
PM 15671433
DA 2025-06-11
ER

PT J
AU Milan, R
   LeLorier, J
   Brouillette, MJ
   Holbrook, A
   Litvinov, IV
   Rahme, E
AF Milan, Raymond
   LeLorier, Jacques
   Brouillette, Marie-Josee
   Holbrook, Anne
   Litvinov, Ivan V.
   Rahme, Elham
TI Sex Differences in the Patterns of Systemic Agent use Among Patients
   With Psoriasis: A Retrospective Cohort Study in Quebec, Canada
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Article
DE sex; biologic agents; conventional systemic agents; treatment patterns;
   psoriasis
ID METABOLIC SYNDROME; CLINICAL-RESPONSE; DOUBLE-BLIND; IMPACT; CARE;
   POPULATION; DEPRESSION; ARTHRITIS; ADULTS; EPIDEMIOLOGY
AB Background: Sex differences exist in psoriasis manifestation and expectations from treatment with systemic agents, including, conventional systemic agents (CSA) and tumor necrosis factor inhibitors or ustekinumab (TNFi/UST). However, sex differences in patterns of systemic agent use, such as CSA discontinuation and switch from CSA to TNFi/UST have not been examined.Objectives: To assess sex differences in patterns of CSA use and identify factors associated with switch to (or add) a TNFi/UST and those associated with CSA discontinuation.Methods: We conducted a retrospective cohort study using the Quebec health administrative databases. We included patients with psoriasis initiating a CSA in 2002-2015. We excluded patients with a psoriasis diagnosis in the 3 years prior to the first diagnosis date between 2002 and 2015, and those with a systemic agent dispensation in the year prior to that date. We used Cox regression models with the Least Absolute Shrinkage and Selection Operator method to identify factors associated with Switch/add TNFi/UST, and those associated with CSA discontinuation. Separate analyses were performed for male and female patients.Results: We included 1,644 patients (55.7% females, mean age 60.3 years), among whom 60.4% discontinued their CSA and 7.4%, switched/added TNFi/UST (3.4% switched and 4.0% added) within a median of 0.78 years of follow-up. Among male and female patients, rates of Switch/add TNFi/UST per 1,000 person-year were 49.1 and 41.0 and rates of CSA discontinuation were 381.2 and 352.8. Clinical obesity in male patients (HR 3.53, 95% CI 1.20-10.35), and adjustment/somatoform/dissociative disorders (HR 3.17, 95% CI 1.28-7.85) and use of nonsteroidal anti-inflammatory drugs (HR 2.70, 95% CI 1.56-4.70) in female patients were associated with Switch/add TNFi/UST. Male patients followed by a rheumatologist (HR 0.66, 95% CI 0.46-0.94) and those with a prior hospitalization (HR 0.70, 95% CI 0.57-0.87) were at lower risk of CSA discontinuation, while those initiated on acitretin (vs methotrexate) were at higher risk to discontinue their CSA (HR 1.61, 95% CI 1.30-2.01). Female patients with rheumatoid arthritis comorbidity (HR 0.69, 95% CI 0.51-0.93), those with a dispensed lipid-lowering agent (HR 0.72, 95% CI 0.59-0.88) and hypoglycemic agent (HR 0.75, 95% CI 0.57-0.98) and those initiated on methotrexate (vs all other CSAs) were less likely to discontinue their CSA. Male and female patients entering the cohort between 2011 and 2015 were at reduced risk of CSA discontinuation compared to those entering the cohort before 2011.Conclusion: Most male and female patients discontinued their CSA within 1 year of follow-up. Our study highlighted sex differences in patients' characteristics associated with switch/add a TNFi/UST and CSA discontinuation; treatment switch and discontinuation may be indications of treatment failure in most patients.
C1 [Milan, Raymond] McGill Univ, Dept Med, Div Expt Med, Montreal, PQ, Canada.
   [Milan, Raymond; Brouillette, Marie-Josee; Rahme, Elham] McGill Univ, Ctr Hlth, Res Inst, Ctr Outcomes Res & Evaluat, Montreal, PQ, Canada.
   [LeLorier, Jacques] Univ Montreal, Fac Med, Montreal, PQ, Canada.
   [LeLorier, Jacques] Ctr Hosp Univ Montreal, Ctr Rech, Montreal, PQ, Canada.
   [Brouillette, Marie-Josee] McGill Univ, Dept Psychiat, Montreal, PQ, Canada.
   [Holbrook, Anne] McMaster Univ, Dept Med, Div Clin Pharmacol & Toxicol, Hamilton, ON, Canada.
   [Holbrook, Anne] McMaster Univ, Dept Hlth Res Methods Evidence & Impact, Hamilton, ON, Canada.
   [Holbrook, Anne] St Josephs Healthcare Hamilton, Res Inst St Joes Hamilton, Hamilton, ON, Canada.
   [Litvinov, Ivan V.] McGill Univ, Dept Med, Div Dermatol, Montreal, PQ, Canada.
   [Rahme, Elham] McGill Univ, Dept Med, Div Clin Epidmiol, Montreal, PQ, Canada.
C3 McGill University; McGill University; Universite de Montreal; Universite
   de Montreal; McGill University; McMaster University; McMaster
   University; McMaster University; McGill University; McGill University
RP Rahme, E (corresponding author), McGill Univ, Ctr Hlth, Res Inst, Ctr Outcomes Res & Evaluat, Montreal, PQ, Canada.; Rahme, E (corresponding author), McGill Univ, Dept Med, Div Clin Epidmiol, Montreal, PQ, Canada.
EM Elham.Rahme@mcgill.ca
RI Brouillette, Marie-Josee/AGX-7314-2022
FU Fonds de Recherche du Quebec-Sante (FRQS, Quebec foundation for Health
   Research) doctoral training award; Canadian Institutes of Health
   Research (CIHR) Drug Safety and Effectiveness Cross-Disciplinary
   Training (DSECT) program award; Junior I Clinician Scientist award from
   the FRQS
FX RM is supported by the Fonds de Recherche du Quebec-Sante (FRQS, Quebec
   foundation for Health Research) doctoral training award and the Canadian
   Institutes of Health Research (CIHR) Drug Safety and Effectiveness
   Cross-Disciplinary Training (DSECT) program award. IL is supported by a
   Junior I Clinician Scientist award from the FRQS and has received
   consulting fees from Novartis, Janssen, Galderma and BristolMyers Squibb
   in the course of unrelated studies. ER has received funds and consulting
   fees from Janssen in the course of an unrelated study.
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NR 63
TC 2
Z9 2
U1 0
U2 1
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD FEB 15
PY 2022
VL 13
AR 810309
DI 10.3389/fphar.2022.810309
PG 11
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA ZM3ST
UT WOS:000764282300001
PM 35242034
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Grashow, R
   Weisskopf, MG
   Miller, KK
   Nathan, DM
   Zafonte, R
   Speizer, FE
   Courtney, TK
   Baggish, A
   Taylor, HA
   Pascual-Leone, A
   Nadler, LM
   Roberts, AL
AF Grashow, Rachel
   Weisskopf, Marc G.
   Miller, Karen K.
   Nathan, David M.
   Zafonte, Ross
   Speizer, Frank E.
   Courtney, Theodore K.
   Baggish, Aaron
   Taylor, Herman A.
   Pascual-Leone, Alvaro
   Nadler, Lee M.
   Roberts, Andrea L.
TI Association of Concussion Symptoms With Testosterone Levels and Erectile
   Dysfunction in Former Professional US-Style Football Players
SO JAMA NEUROLOGY
LA English
DT Article
ID TRAUMATIC BRAIN-INJURY; DISEASE RISK-FACTORS; PITUITARY DYSFUNCTION;
   ANTIPITUITARY ANTIBODIES; PREMATURE EJACULATION; SEXUAL DYSFUNCTION;
   METABOLIC SYNDROME; SELF-ASSESSMENT; DRUG-USE; DEPRESSION
AB This cross-sectional study examines the association between self-reported concussion symptoms at the time of US-style football injury and self-reported low testosterone levels and erectile dysfunction indicators in US former professional football players.
   Question Are professional US-style football players with a history of multiple concussion symptoms more likely to report indicators of low testosterone levels or erectile dysfunction (ED)? Findings In this cross-sectional study of 3409 former players, a monotonically increasing association was found between the number of concussion symptoms and the odds of reporting an indicator of low testosterone level and ED. Meaning Concussion symptoms among former football players were associated with low testosterone levels and ED indicators, suggesting that men with a history of head injury may benefit from discussions with their health care clinicians regarding these treatable outcomes.
   Importance Small studies suggest that head trauma in men may be associated with low testosterone levels and sexual dysfunction through mechanisms that likely include hypopituitarism secondary to ischemic injury and pituitary axonal tract damage. Athletes in contact sports may be at risk for pituitary insufficiencies or erectile dysfunction (ED) because of the high number of head traumas experienced during their careers. Whether multiple symptomatic concussive events are associated with later indicators of low testosterone levels and ED is unknown. Objective To explore the associations between concussion symptom history and participant-reported indicators of low testosterone levels and ED. Design, Setting, and Participants This cross-sectional study of former professional US-style football players was conducted in Boston, Massachusetts, from January 2015 to March 2017. Surveys on past football exposures, demographic factors, and current health conditions were sent via electronic and postal mail to participants within and outside of the United States. Analyses were conducted in Boston, Massachusetts; the data analysis began in March 2018 and additional analyses were performed through June 2019. Of the 13720 male former players eligible to enroll who were contacted, 3506 (25.6%) responded. Exposures Concussion symptom score was calculated by summing the frequency with which participants reported 10 symptoms, such as loss of consciousness, disorientation, nausea, memory problems, and dizziness, at the time of football-related head injury. Main Outcomes and Measures Self-reported recommendations or prescriptions for low testosterone or ED medication served as indicators for testosterone insufficiency and ED. Results In 3409 former players (mean [SD] age, 52.5 [14.1] years), the prevalence of indicators of low testosterone levels and ED was 18.3% and 22.7%, respectively. The odds of reporting low testosterone levels or ED indicators were elevated for previously established risk factors (eg, diabetes, sleep apnea, and mood disorders). Models adjusted for demographic characteristics, football exposures, and current health factors showed a significant monotonically increasing association of concussion symptom score with the odds of reporting the low testosterone indicator (highest vs lowest quartile, odds ratio, 2.39; 95% CI, 1.79-3.19; P < .001). The ED indicator showed a similar association (highest quartile vs lowest, odds ratio, 1.72; 95% CI, 1.30-2.27; P < .001). Conclusions and Relevance Concussion symptoms at the time of injury among former football players were associated with current participant-reported low testosterone levels and ED indicators. These findings suggest that men with a history of head injury may benefit from discussions with their health care clinicians regarding testosterone deficiency and sexual dysfunction.
C1 [Grashow, Rachel; Weisskopf, Marc G.; Speizer, Frank E.; Courtney, Theodore K.; Roberts, Andrea L.] Harvard TH Chan Sch Publ Hlth, Dept Environm Hlth, 655 Huntington Ave,Bldg 1,Ste 1402, Boston, MA 02215 USA.
   [Grashow, Rachel; Weisskopf, Marc G.; Miller, Karen K.; Nathan, David M.; Zafonte, Ross; Speizer, Frank E.; Courtney, Theodore K.; Baggish, Aaron; Taylor, Herman A.; Pascual-Leone, Alvaro; Nadler, Lee M.] Harvard Med Sch, Football Players Hlth Study, Boston, MA 02115 USA.
   [Weisskopf, Marc G.; Courtney, Theodore K.] Harvard TH Chan Sch Publ Hlth, Environm & Occupat Med & Epidemiol Program, Boston, MA USA.
   [Miller, Karen K.] Massachusetts Gen Hosp, Dept Med, Neuroendocrine Unit, Boston, MA 02114 USA.
   [Miller, Karen K.] Harvard Med Sch, Boston, MA 02115 USA.
   [Nathan, David M.] Massachusetts Gen Hosp, Ctr Diabet, Boston, MA 02114 USA.
   [Nathan, David M.] Harvard Med Sch, Dept Med, Boston, MA 02115 USA.
   [Zafonte, Ross] Spaulding Rehabil Hosp, Dept Phys Med & Rehabil, Boston, MA USA.
   [Zafonte, Ross] Harvard Med Sch, Massachusetts Gen Hosp, Boston, MA 02115 USA.
   [Zafonte, Ross] Harvard Med Sch, Brigham & Womens Hosp, Boston, MA 02115 USA.
   [Speizer, Frank E.] Harvard Med Sch, Channing Div Network Med, Brigham & Womens Hosp, Boston, MA 02115 USA.
   [Baggish, Aaron] Massachusetts Gen Hosp, Cardiovasc Performance Program, Boston, MA 02114 USA.
   [Taylor, Herman A.] Morehouse Sch Med, Cardiovasc Res Inst, Atlanta, GA 30310 USA.
   [Pascual-Leone, Alvaro] Harvard Med Sch, Beth Israel Deaconess Med Ctr, Berenson Allen Ctr Noninvas Brain Stimulat, Div Cognit Neurol,Dept Neurol, Boston, MA 02115 USA.
   [Nadler, Lee M.] Dana Farber Canc Inst, Boston, MA 02115 USA.
C3 Harvard University; Harvard T.H. Chan School of Public Health; Harvard
   University; Harvard Medical School; Harvard University; Harvard T.H.
   Chan School of Public Health; Harvard University; Harvard University
   Medical Affiliates; Massachusetts General Hospital; Harvard University;
   Harvard Medical School; Harvard University; Harvard University Medical
   Affiliates; Massachusetts General Hospital; Harvard University; Harvard
   Medical School; Harvard University; Harvard Medical School; Harvard
   University Medical Affiliates; Spaulding Rehabilitation Hospital;
   Harvard University; Harvard University Medical Affiliates; Massachusetts
   General Hospital; Harvard Medical School; Harvard University; Harvard
   Medical School; Harvard University Medical Affiliates; Brigham & Women's
   Hospital; Harvard University; Harvard University Medical Affiliates;
   Brigham & Women's Hospital; Harvard Medical School; Harvard University;
   Harvard University Medical Affiliates; Massachusetts General Hospital;
   Morehouse School of Medicine; Harvard University; Harvard Medical
   School; Harvard University Medical Affiliates; Beth Israel Deaconess
   Medical Center; Harvard University; Harvard University Medical
   Affiliates; Dana-Farber Cancer Institute
RP Grashow, R (corresponding author), Harvard TH Chan Sch Publ Hlth, Dept Environm Hlth, 655 Huntington Ave,Bldg 1,Ste 1402, Boston, MA 02215 USA.
EM rgrashow@hsph.harvard.edu
RI Pascual-Leone, Alvaro/AAC-5101-2019; Courtney, Theodore/P-4829-2019;
   Miller, Karen/AAI-6901-2021
OI Baggish, Aaron/0000-0003-2042-1489
FU Sidney R. Baer Jr Foundation; National Institutes of Health
   [R01MH100186, R21AG051846, R01MH111875, R01MH115949, R01 MH117063,
   R24AG06142, P01 AG031720]; National Science Foundation; DARPA; Football
   Players Health Study at Harvard University; Harvard Catalyst/The Harvard
   Clinical and Translational Science Center (National Center for Research
   Resources); Harvard Catalyst/The Harvard Clinical and Translational
   Science Center (National Center for Advancing Translational Studies
   National Institutes of Health [UL1 RR025758]; NFLPA
FX This study was partly supported by the Sidney R. Baer Jr Foundation, the
   National Institutes of Health (grants R01MH100186, R21AG051846,
   R01MH111875, R01MH115949, R01 MH117063, R24AG06142, and P01 AG031720),
   the National Science Foundation, DARPA, the Football Players Health
   Study at Harvard University, and Harvard Catalyst/The Harvard Clinical
   and Translational Science Center (National Center for Research Resources
   and the National Center for Advancing Translational Studies National
   Institutes of Health grant UL1 RR025758; Dr Pascual Leone) as well as
   the NFLPA.
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NR 89
TC 32
Z9 33
U1 2
U2 6
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 2168-6149
EI 2168-6157
J9 JAMA NEUROL
JI JAMA Neurol.
PD DEC
PY 2019
VL 76
IS 12
BP 1428
EP 1438
DI 10.1001/jamaneurol.2019.2664
PG 11
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology
GA JZ6BI
UT WOS:000505186000006
PM 31449296
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Ohdo, S
   Koyanagi, S
   Matsunaga, N
AF Ohdo, Shigehiro
   Koyanagi, Satoru
   Matsunaga, Naoya
TI Chronopharmacological strategies focused on chrono-drug discovery
SO PHARMACOLOGY & THERAPEUTICS
LA English
DT Review
DE Chrono-DDS; Chronopharmacokinetics; Chronopharmacology; Chronotherapy;
   Clock gene
ID ACTIVATING TRANSCRIPTION FACTOR-4; REGULATING 24-HOUR RHYTHM; MAMMALIAN
   CIRCADIAN CLOCK; TIME-DEPENDENT CHANGES; SLEEP-PHASE SYNDROME;
   SUPRACHIASMATIC NUCLEUS; INTESTINAL EXPRESSION; CORTICOSTERONE RHYTHM;
   RELEASE PREDNISONE; PERIPHERAL-TISSUES
AB In mammals, the circadian pacemaker resides in the paired suprachiasmatic nuclei (SCN) and influences a multitude of biological processes, including the sleep-wake rhythm. Circadian rhythms regulate diverse physiologic processes, including homeostatic functions of steroid hormones and their receptors. Perturbation of these rhythms is associated with pathogenic conditions such as cancer, metabolic syndrome, cardiovascular disease, sleep disorder and depression. Clock genes ultimately control a vast array of circadian rhythms involved in physiology and behavior. They regulate several diseases described above. Chronotherapy is especially relevant when the risk and/or intensity of symptoms of a disease vary predictably over time. The effectiveness and toxicity of several drugs vary depending on the dosing time. Such chronopharmacological phenomena are influenced by not only the pharmacodynamics but also the pharmacokinetics of a medication. The underlying mechanisms are associated with the 24-h rhythms of biochemical, physiological, and behavioral processes under the control of the circadian clock. Identifying a rhythmic marker based on the molecular clock for choosing dosing time can lead to the progress and diffusion of chronopharmacotherapy. To monitor the rhythmic markers such as clock genes, it might be useful to choose the most appropriate time of a day for the administration of a drug, to increase its therapeutic effects and/or reduce its side effects. On the contrary, several drugs affect the molecular clock and alter the 24-h rhythms of various processes. Alterations in rhythmicity are sometimes associated with therapeutic effects, or it might lead to illness and altered homeostatic regulation. Furthermore, to produce new rhythmicity by manipulating the molecular clock of organs by rhythmic administration of drugs at altered feeding schedules appears to lead to a new concept of chronopharmacotherapy. An approach to increase the efficiency of pharmacotherapy is administering drugs at times when they are best tolerated. From the perspective of pharmaceutics, the application of biological rhythm to pharmacotherapy can be accomplished by the appropriate timing of administration of conventionally formulated tablets and capsules, and also by the use of special drug-delivery system to synchronize drug concentrations to the rhythms in disease activity. New drugs targeting the molecular clock are being developed to manage diseases in human. For instance, novel molecular mechanisms that mediate renal dysfunction in mice with chronic kidney disease (CKD) have been identified by examining the relationship between the circadian clock and CKD aggravation. The inhibition of cell cycle regulatory factor ameliorated renal inflammation in a mouse model of CKD. A novel inhibitor of cell cycle regulatory factor has been identified, supporting the potential utility of cell cycle regulatory factor inhibition in the treatment of CKD. Although malignant phenotypes of triple negative breast cancer are subject to circadian alterations, the role of cancer stem cells (CSCs) in defining this circadian change remains unclear. The effectiveness of anticancer drugs varies with the circadian dynamics of CSCs, which are regulated by the tumor microenvironmental factors. The finding reveals that the circadian dynamics of CSCs are regulated by the tumor microenvironment and provides a proof of principle of its implication for chronotherapy against triple-negative breast cancer.
   Therefore, we present an overview of the dosing-time-dependent alterations in therapeutic outcome and safety of a drug and the regulatory system of biological rhythm from the perspective of clock genes and the possibility of pharmacotherapy based on the molecular clock. (C) 2019 Elsevier Inc. All rights reserved.
C1 [Ohdo, Shigehiro; Koyanagi, Satoru; Matsunaga, Naoya] Kyushu Univ, Grad Sch Pharmaceut Sci, Dept Pharmaceut, Higashi Ku, 3-1-1 Maidashi, Fukuoka, Fukuoka 8128582, Japan.
C3 Kyushu University
RP Ohdo, S (corresponding author), Kyushu Univ, Grad Sch Pharmaceut Sci, Dept Pharmaceut, Higashi Ku, 3-1-1 Maidashi, Fukuoka, Fukuoka 8128582, Japan.
EM ohdo@phar.kyushu-u.acjp
RI Koyanagi, Satoru/AAE-6843-2020
OI matsunaga2, naoya2/0000-0001-6226-8473
FU Platform Project for Supporting Drug Discovery and Life Science Research
   [Basis for Supporting Innovative Drug Discovery and Life Science
   Research (BINDS)] from AMED [JP18am0101091]
FX This research was supported by Platform Project for Supporting Drug
   Discovery and Life Science Research [Basis for Supporting Innovative
   Drug Discovery and Life Science Research (BINDS)] from AMED under Grant
   Number JP18am0101091.
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Z9 43
U1 2
U2 28
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0163-7258
EI 1879-016X
J9 PHARMACOL THERAPEUT
JI Pharmacol. Ther.
PD OCT
PY 2019
VL 202
BP 72
EP 90
DI 10.1016/j.pharmthera.2019.05.018
PG 19
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA JA9DA
UT WOS:000488149000006
PM 31173839
DA 2025-06-11
ER

PT J
AU Anagnostis, P
   Livadas, S
   Goulis, DG
   Bretz, S
   Ceausu, I
   Durmusoglu, F
   Erkkola, R
   Fistonic, I
   Gambacciani, M
   Geukes, M
   Hamoda, H
   Hartley, C
   Hirschberg, AL
   Meczekalski, B
   Mendoza, N
   Mueck, A
   Smetnik, A
   Stute, P
   van Trotsenburg, M
   Rees, M
   Lambrinoudaki, I
AF Anagnostis, Panagiotis
   Livadas, Sarantis
   Goulis, Dimitrios G.
   Bretz, Silvia
   Ceausu, Iuliana
   Durmusoglu, Fatih
   Erkkola, Risto
   Fistonic, Ivan
   Gambacciani, Marco
   Geukes, Marije
   Hamoda, Haitham
   Hartley, Caoimhe
   Hirschberg, Angelica Linden
   Meczekalski, Blazej
   Mendoza, Nicolas
   Mueck, Alfred
   Smetnik, Antonina
   Stute, Petra
   van Trotsenburg, Mick
   Rees, Margaret
   Lambrinoudaki, Irene
TI EMAS position statement: Vitamin D and menopausal health
SO MATURITAS
LA English
DT Article
DE Vitamin D; Menopause; Postmenopausal women; Vasomotor symptomatology;
   Cardiovascular disease; Cancer; COVID-19
ID SERUM 25-HYDROXYVITAMIN D; POSTMENOPAUSAL WOMEN; D SUPPLEMENTATION; D
   DEFICIENCY; D INADEQUACY; CARDIOVASCULAR-DISEASE; PRIMARY PREVENTION;
   FRACTURE RISK; METAANALYSIS; CALCIUM
AB Introduction: There is increasing evidence that vitamin D has widespread tissue effects. In addition to osteopo-rosis, vitamin D deficiency has been associated with cardiovascular disease, diabetes, cancer, infections and neurodegenerative disease. However, the effect of vitamin D supplementation on non-skeletal outcomes requires clarification, especially in postmenopausal women.Aim: This position statement provides an evidence-based overview of the role of vitamin D in the health of postmenopausal women based on observational and interventional studies.Materials and methods: Literature review and consensus of expert opinion.Results and conclusions: Vitamin D status is determined by measuring serum 25-hydroxyvitamin D levels. Con-centrations <20 ng/ml (<50 nmol/l) and <10 ng/ml (<25 nmol/l) are considered to constitute vitamin D deficiency and severe deficiency, respectively. Observational data suggest an association between vitamin D deficiency and adverse health outcomes in postmenopausal women, although they cannot establish causality.The evidence from randomized controlled trials concerning vitamin D supplementation is not robust, since many studies did not consider whether people were deficient at baseline. Moreover, high heterogeneity exists in terms of the population studied, vitamin D dosage, calcium co-administration and duration of intervention.Concerning skeletal health, vitamin D deficiency is associated with low bone mass and an increased risk of fractures. Vitamin D supplementation at maintenance doses of 800-2000 IU/day (20-50 mu g/day), after repletion of vitamin D status with higher weekly or daily doses, may be of benefit only when co-administered with calcium (1000-1200 mg/day), especially in the elderly populations and those with severe vitamin D deficiency. Concerning cardiovascular disease, vitamin D deficiency is associated with an increased prevalence of cardio-vascular risk factors, mainly metabolic syndrome, type 2 diabetes mellitus and dyslipidemia. Vitamin D defi-ciency, especially its severe form, is associated with an increased risk of cardiovascular events (coronary heart disease, stroke, mortality), independently of traditional risk factors. Vitamin D supplementation may have a modestly beneficial effect on lipid profile and glucose homeostasis, especially in obese individuals or those >= 60 years old and at doses of >= 2000 IU/day (>= 50 mu g/day). However, it has no effect on the incidence of cardio-vascular events.Concerning cancer, vitamin D deficiency is associated with increased incidence of and mortality from several types of cancer, such as colorectal, lung and breast cancer. However, the data on other types of gynecological cancer are inconsistent. Vitamin D supplementation has no effect on cancer incidence, although a modest reduction in cancer-related mortality has been observed.Concerning infections, vitamin D deficiency has been associated with acute respiratory tract infections, including coronavirus disease 2019 (COVID-19). Vitamin D supplementation may decrease the risk of acute respiratory tract infections and the severity of COVID-19 (not the risk of infection).Concerning menopausal symptomatology, vitamin D deficiency may have a negative impact on some aspects, such as sleep disturbances, depression, sexual function and joint pains. However, vitamin D supplementation has no effect on these, except for vulvovaginal atrophy, at relatively high doses, i.e., 40,000-60,000 IU/week (1000-1500 IU/week) orally or 1000 IU/day (25 mu g/day) as a vaginal suppository.
C1 [Anagnostis, Panagiotis; Goulis, Dimitrios G.] Aristotle Univ Thessaloniki, Med Sch, Dept Obstet & Gynecol 1, Unit Reprod Endocrinol, Thessaloniki, Greece.
   [Livadas, Sarantis] Athens Med Ctr, Endocrine Unit, Athens, Greece.
   [Bretz, Silvia] Clin Silvia Bretz, Rio De Janeiro, Brazil.
   [Ceausu, Iuliana] Carol Davila Univ Med & Pharm, Dr I Cantacuzino Clin Hosp, Dept Obstet & Gynecol 1, Bucharest, Romania.
   [Durmusoglu, Fatih] Istanbul Medipol Int, Sch Med, Istanbul, Turkey.
   [Erkkola, Risto] Univ Cent Hosp, Dept Obstet & Gynecol, Turku, Finland.
   [Fistonic, Ivan] Inst Womens Hlth, Zagreb, Croatia.
   [Gambacciani, Marco] San Rossore Clin Ctr, Menopause & Osteoporosis Unit, Pisa, Italy.
   [Geukes, Marije] Hosp Grp Twente, Dept Obstet & Gynecol, Ziekenhuisgroep Twente, POB 7600, NL-7600 SZ Almelo, Netherlands.
   [Hamoda, Haitham] Kings Coll Hosp London, Dept Gynaecol, Denmark Hill, London SE5 9RS, England.
   [Hartley, Caoimhe] Rotunda Hosp, Menopause Hlth Clin, Med Sch, Dept Obstet & Gynecol 2, Dublin, Ireland.
   [Hirschberg, Angelica Linden] Karolinska Inst, Dept Womens & Childrens Hlth, Stockholm, Sweden.
   [Hirschberg, Angelica Linden] Karolinska Univ Hosp, Dept Gynecol & Reprod Med, Stockholm, Sweden.
   [Meczekalski, Blazej] Poznan Univ Med Sci, Dept Gynecol Endocrinol, Poznan, Poland.
   [Mendoza, Nicolas] Univ Granada, Dept Obstet & Gynecol, Granada, Spain.
   [Mueck, Alfred] Univ Hosp Tuebingen, Dept Womens Hlth, Tubingen, Germany.
   [Mueck, Alfred] Capital Med Univ, Beijing OB GYN Hosp, Beijing, Peoples R China.
   [Smetnik, Antonina] Minist Healthcare Russian Federat, Dept Gynecol Endocrinol, Natl Med Res Ctr Obstet Gynecol & Perinatol, Moscow, Russia.
   [Stute, Petra] Univ Clin Inselspital, Dept Obstet & Gynecol, Bern, Switzerland.
   [van Trotsenburg, Mick] Sigmund Freud Univ, Vienna, Austria.
   [van Trotsenburg, Mick] Consultancy genderPRO, Vienna, Austria.
C3 Aristotle University of Thessaloniki; Carol Davila University of
   Medicine & Pharmacy; University of Turku; King's College Hospital NHS
   Foundation Trust; King's College Hospital; Karolinska Institutet;
   Karolinska Institutet; Karolinska University Hospital; Poznan University
   of Medical Sciences; University of Granada; Eberhard Karls University of
   Tubingen; Eberhard Karls University Hospital; Capital Medical
   University; Russian Academy of Medical Sciences; Research Center for
   Obstetrics, Gynecology & Perinatology; University of Bern; University
   Hospital of Bern
RP Anagnostis, P (corresponding author), Aristotle Univ Thessaloniki, Med Sch, Dept Obstet & Gynecol 1, Unit Reprod Endocrinol, Thessaloniki, Greece.
EM pan.anagnostis@gmail.com
RI Livadas, Sarantis/D-2668-2014; Gambacciani, Marco/AAO-2858-2021;
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OI Hirschberg, Angelica Linden/0000-0001-6481-6277; Stute,
   Petra/0000-0002-5591-1552
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NR 92
TC 17
Z9 18
U1 7
U2 35
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0378-5122
EI 1873-4111
J9 MATURITAS
JI Maturitas
PD MAR
PY 2023
VL 169
BP 2
EP 9
DI 10.1016/j.maturitas.2022.12.006
EA DEC 2022
PG 8
WC Geriatrics & Gerontology; Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology; Obstetrics & Gynecology
GA 7X4PE
UT WOS:000914182100001
PM 36566517
OA Bronze
DA 2025-06-11
ER

PT J
AU Chen, YS
   Zhu, XX
   Zhao, XY
   Xing, HY
   Li, YG
AF Chen Yong-Song
   Zhu Xu-Xin
   Zhao Xiao-Yun
   Xing Han-Ying
   Li Yu-Guang
TI Hemin, a heme oxygenase-1 inducer, improves aortic endothelial
   dysfunction in insulin resistant rats
SO CHINESE MEDICAL JOURNAL
LA English
DT Article
DE heme oxygenase-1; hemin; insulin resistance; oxidative stress
ID NITRIC-OXIDE SYNTHASE; SMOOTH-MUSCLE-CELLS; OXIDATIVE STRESS;
   CARBON-MONOXIDE; SERINE PHOSPHORYLATION; VASCULAR-RESPONSES; METABOLIC
   SYNDROME; ATHEROSCLEROSIS; EXPRESSION; ACTIVATION
AB Background Under an insulin resistance (IR) state, overproduction of reactive oxygen species (ROS) may be playing a major role in the pathogenesis of endothelial dysfunction, hypertension and atherosclerosis. Recently, increasing attention has been drawn to the beneficial effects of heme oxygenase-1 (HO-1) in the cardiovascular system. This study aimed to investigate the effects of HO-1 on vascular function of thoracic aorta in IR rats and demonstrate the probable mechanisms of HO-1 against endothelial dysfunction in IR states.
   Methods Sprague-Dawley (SD) rats fed with high-fat diet for 6 weeks and the IR models were validated with hyperinsulinemic-euglycemic clamp test. Then the IR rat models (n=44) were further randomized into 3 subgroups, namely, the IR control group (n=26, in which 12 were sacrificed immediately and evaluated for all study measures), a hemin treated IR group (n=10) and a zinc protoporphyrin-IX (ZnPP-IX) treated IR group (n=8) that were fed with a high-fat diet. Rats with standardized chow diet were used as the normal control group (n=12). The rats in IR control group, hemin treated IR group and ZnPP-IX treated IR group were subsequently treated every other day with an intraperitoneal injection of normal saline, hemin (inducer of HO-1, 30 mu mol/kg) or ZnPP-IX (inhibitor of HO-1, 10 mu mol/kg) for 4 weeks. Rats in the normal control group remained on a standardized chow diet and were treated with intraperitoneal injections of normal saline every other day for 4 weeks. Systolic arterial blood pressure (SABP) was measured by tail-cuffed microphotoelectric plethysmography. The blood carbon monoxide (CO) was measured by blood gas analysis. The levels of nitric oxide (NO), inducible nitric oxide synthase (NOS), endothelial nitric oxide synthase (eNOS), blood glucose (BG), insulin, total cholesterol (TC) and triglycericle (TG) in serum, and the levels of total antioxidant capacity (TAOC), malondialdehyde (MDA) and superoxide dismutase (SOD) in the aorta were measured. The expression of HO-1 mRNA and HO-1 protein in aortal tissue were detected by semi-quantitative RT-PCR and Western blot. The vasoreactive tensometry was performed with thoracic aortic rings (TARs).
   Results Compared with the normal control group, the levels of SABP, BG, insulin, TC, TG, NO, NOS and MDA were higher, while the levels of CO, TAOC, SOD and eNOS were lower in IR control rats. After treatment of IR rats for 4 weeks a more intensive expression of HO-1 mRNA and HO-1 protein were observed in hemin treated IR group compared with the normal control group. And compared with 4-week IR control rats, the levels of CO, TAOC, SOD and eNOS were increased, while the levels of SABP and NOS activity were lower in the hemin treated IR group. Administration of hemin in IR rats appeared to improve the disordered vasorelaxation of TARs to acetylcholine (ACh). Alternatively, the reverse results of SABP, CO, TAOC, SOD, NOS and vasorelaxation responses to ACh were observed in IR rats with administration of ZnPP-IX.
   Conclusions The endothelial dysfunction in the aorta is present in the IR state. The protective effects of HO-1 against aortic endothelial dysfunction may be due to its antioxidation and regulative effect of vasoactive substances. It is proposed that hemin, inducer of HO-1, could be a potential therapeutic option for vascular dysfunction in IR states.
C1 [Li Yu-Guang] Shantou Univ Med Coll, Affiliated Hosp 1, Dept Cardiol, Shantou 515041, Guangdong, Peoples R China.
   [Chen Yong-Song; Zhu Xu-Xin] Shantou Univ Med Coll, Affiliated Hosp 1, Dept Endocrinol, Shantou 515041, Guangdong, Peoples R China.
   [Zhao Xiao-Yun; Xing Han-Ying] Hebei Provincial Geriat Key Lab, Shijiazhuang 050051, Hebei, Peoples R China.
C3 Shantou University; Shantou University
RP Li, YG (corresponding author), Shantou Univ Med Coll, Affiliated Hosp 1, Dept Cardiol, Shantou 515041, Guangdong, Peoples R China.
EM yglee317@126.com
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NR 24
TC 17
Z9 20
U1 0
U2 2
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, 400059, INDIA
SN 0366-6999
J9 CHINESE MED J-PEKING
JI Chin. Med. J.
PD FEB 5
PY 2008
VL 121
IS 3
BP 241
EP 247
DI 10.1097/00029330-200802010-00012
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 261YT
UT WOS:000253116600012
PM 18298918
OA gold
DA 2025-06-11
ER

PT J
AU Kinshella, MLW
   Omar, S
   Scherbinsky, K
   Vidler, M
   Magee, LA
   von Dadelszen, P
   Moore, SE
   Elango, R
AF Kinshella, Mai-Lei Woo
   Omar, Shazmeen
   Scherbinsky, Kerri
   Vidler, Marianne
   Magee, Laura A.
   von Dadelszen, Peter
   Moore, Sophie E.
   Elango, Rajavel
CA PRECISE Conceptual Framework Worki
TI Maternal nutritional risk factors for pre-eclampsia incidence: findings
   from a narrative scoping review
SO REPRODUCTIVE HEALTH
LA English
DT Review
ID PREGNANCY-INDUCED HYPERTENSION; POLYUNSATURATED FATTY-ACIDS; VITAMIN-D
   DEFICIENCY; CALCIUM INTAKE; OXIDATIVE STRESS; PARATHYROID-HORMONE;
   MEDITERRANEAN DIET; METABOLIC SYNDROME; PRETERM DELIVERY; ZINC LEVEL
AB Background: Pre-eclampsia is a leading cause of maternal mortality and morbidity that involves pregnancy-related stressors on the maternal cardiovascular and metabolic systems. As nutrition is important to support optimal development of the placenta and for the developing fetus, maternal diets may play a role in preventing pre-eclampsia. The purpose of this scoping review is to map the maternal nutritional deficiencies and imbalances associated with pre-eclampsia incidence and discuss evidence consistency and linkages with current understandings of the etiology of pre-eclampsia.
   Methods: A narrative scoping review was conducted to provide a descriptive account of available research, summarize research findings and identify gaps in the evidence base. Relevant observational studies and reviews of observational studies were identified in an iterative two-stage process first involving electronic database searches then more sensitive searches as familiarity with the literature increased. Results were considered in terms of their consistency of evidence, effect sizes and biological plausibility.
   Results: The review found evidence for associations between nutritional inadequacies and a greater risk of pre-eclampsia. These associations were most likely mediated through oxidative stress, inflammation, maternal endothelial dysfunction and blood pressure in the pathophysiology of pre-eclampsia. Maternal nutritional risk factors for pre-eclampsia incidence with the strongest consistency, effect and biological plausibility include vitamin C and its potential relationship with iron status, vitamin D (both on its own and combined with calcium and magnesium), and healthy dietary patterns featuring high consumption of fruits, vegetables, whole grains, fish, seafood and monounsaturated vegetable oils. Foods high in added sugar, such as sugary drinks, were associated with increased risk of pre-eclampsia incidence.
   Conclusion: A growing body of literature highlights the involvement of maternal dietary factors in the development of pre-eclampsia. Our review findings support the need for further investigation into potential interactions between dietary factors and consideration of nutritional homeostasis and healthy dietary patterns. Further research is recommended to explore gestational age, potential non-linear relationships, dietary diversity and social, cultural contexts of food and meals.
   Plain language summary: Pre-eclampsia is a condition of high blood pressure during the second half of pregnancy with signs of damage to another organ system, often the liver and kidneys. It is a serious and potentially deadly disease and is the second top cause of deaths related to pregnancy and childbirth globally. Though the exact cause of pre-eclampsia is unclear, researchers have discovered that pre-eclampsia develops through abnormal development of the placenta, which is the interface between the growing baby and the mother in the womb. The placenta helps to transfer nutrients, oxygen and waste between the mother and fetus. Nutrition has important roles to play in the development of the placenta and certain vitamins and minerals have clinical properties that may help prevent pre-eclampsia. We conducted a review to summarize observational studies on maternal nutritional risk factors associated with the development of pre-eclampsia. Promising maternal dietary factors that fit with current understandings of how pre-eclampsia develops include vitamin C and its potential relationship with iron, calcium and vitamin D. Healthy dietary patterns with high consumption of fruits, vegetables, whole grains, fish and seafood and monounsaturated vegetable oils are likely beneficial. Foods high in added sugar, such as sugary drinks, may be linked to higher rates of developing pre-eclampsia. Instead of focusing on single nutrient deficiencies, our findings support a broader approach to explore interrelationships between dietary factors and balanced healthy dietary intake for the prevention of pre-eclampsia.
C1 [Kinshella, Mai-Lei Woo; Omar, Shazmeen; Scherbinsky, Kerri; Vidler, Marianne; Magee, Laura A.; von Dadelszen, Peter] BC Childrens & Womens Hosp, Dept Obstet & Gynaecol, Vancouver, BC, Canada.
   [Kinshella, Mai-Lei Woo; Omar, Shazmeen; Scherbinsky, Kerri; Vidler, Marianne; Magee, Laura A.; von Dadelszen, Peter] Univ British Columbia, Vancouver, BC, Canada.
   [Scherbinsky, Kerri; Elango, Rajavel] Univ British Columbia, Dept Pediat, BC Childrens & Womens Hosp, Rm170,950 West 28th Ave, Vancouver, BC, Canada.
   [Magee, Laura A.; von Dadelszen, Peter; Moore, Sophie E.] Kings Coll London, Dept Women & Childrens Hlth, London, England.
   [Moore, Sophie E.] Sch Hyg & Trop Med, MRC Unit Gambia London, Fajara, Gambia.
   [Elango, Rajavel] Univ British Columbia, Sch Populat & Publ Hlth, Vancouver, BC, Canada.
C3 University of British Columbia; University of British Columbia;
   University of British Columbia; University of London; King's College
   London; University of British Columbia
RP Elango, R (corresponding author), Univ British Columbia, Dept Pediat, BC Childrens & Womens Hosp, Rm170,950 West 28th Ave, Vancouver, BC, Canada.
EM relango@bcchr.ubc.ca
RI von Dadelszen, Peter/AAP-7480-2021; Kinshella, Mai-Lei
   Woo/AAA-8117-2022; Chappell, Lucy/U-4778-2018
OI Magee, Laura/0000-0002-1355-610X; Elango, Rajavel/0000-0002-9380-1725;
   Wanyonyi, Sikolia/0000-0001-6160-8720; Scherbinsky,
   Kerri/0000-0003-2311-808X; Shennan, Andrew/0000-0001-5273-3132; Koech,
   Angela/0000-0003-4838-3269; Jah, Hawanatu/0000-0002-4347-5247;
   Kinshella, Mai-Lei Woo/0000-0001-5846-3014; Chappell,
   Lucy/0000-0001-6219-3379; von Dadelszen, Peter/0000-0003-4136-3070;
   Taylor Salisbury, Tatiana/0000-0002-8249-3886; Moore,
   Sophie/0000-0003-1650-3238; OMUSE, GEOFFREY/0000-0002-3866-5118; Lawn,
   Joy E/0000-0002-4573-1443; Mlambo, Reason/0000-0001-6661-2841
FU UK Research and Innovation Grand Challenges Research Fund GROW Award
   scheme [MR/P027938/1]; Vanier Canada Graduate Scholarship - Government
   of Canada through the Canadian Institutes of Health Research (CIHR);
   Canadian Institute of Health Research [FRN 10321]
FX The PRECISE Network is funded by the UK Research and Innovation Grand
   Challenges Research Fund GROW Award scheme (Grant number: MR/P027938/1).
   MWK is supported by the Vanier Canada Graduate Scholarship funded by the
   Government of Canada through the Canadian Institutes of Health Research
   (CIHR); and Canadian Institute of Health Research (FRN 10321) to R.E.
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NR 129
TC 21
Z9 21
U1 0
U2 15
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1742-4755
J9 REPROD HEALTH
JI Reprod. Health
PD SEP 5
PY 2022
VL 19
IS 1
AR 188
DI 10.1186/s12978-022-01485-9
PG 13
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA 4H7OI
UT WOS:000850066000001
PM 36064716
OA Green Published, gold, Green Accepted
DA 2025-06-11
ER

PT J
AU Liu, C
   Schönke, M
   Spoorenberg, B
   Lambooij, JM
   van der Zande, HJP
   Zhou, EN
   Tushuizen, ME
   Andreasson, AC
   Park, A
   Oldham, S
   Uhrbom, M
   Ahlstedt, I
   Ikeda, Y
   Wallenius, K
   Peng, XR
   Guigas, B
   Boon, MR
   Wang, YN
   Rensen, PC
AF Liu, Cong
   Schonke, Milena
   Spoorenberg, Borah
   Lambooij, Joost M.
   van der Zande, Hendrik J. P.
   Zhou, Enchen
   Tushuizen, Maarten E.
   Andreasson, Anne-Christine
   Park, Andrew
   Oldham, Stephanie
   Uhrbom, Martin
   Ahlstedt, Ingela
   Ikeda, Yasuhiro
   Wallenius, Kristina
   Peng, Xiao-Rong
   Guigas, Bruno
   Boon, Mariëtte R.
   Wang, Yanan
   Rensen, Patrick C. N.
TI FGF21 protects against hepatic lipotoxicity and macrophage activation to
   attenuate fibrogenesis in nonalcoholic steatohepatitis
SO ELIFE
LA English
DT Article
DE fibroblast growth factor 21; steatohepatitis; lipid; scar-associated
   macrophages; liver-adipose tissue crosstalk; Mouse
ID FATTY LIVER-DISEASE; METABOLIC SYNDROME; ADIPOSE-TISSUE; KUPFFER CELLS;
   PATHOGENESIS; FIBROSIS; GLUCOSE; MICE; ATHEROSCLEROSIS; TRIACYLGLYCEROL
AB Analogues of the hepatokine fibroblast growth factor 21 (FGF21) are in clinical development for type 2 diabetes and nonalcoholic steatohepatitis (NASH) treatment. Although their glucose-lowering and insulin-sensitizing effects have been largely unraveled, the mechanisms by which they alleviate liver injury have only been scarcely addressed. Here, we aimed to unveil the mechanisms underlying the protective effects of FGF21 on NASH using APOE*3-Leiden.CETP mice, a well-established model for human-like metabolic diseases. Liver-specific FGF21 overexpression was achieved in mice, followed by administration of a high-fat high-cholesterol diet for 23 weeks. FGF21 prevented hepatic lipotoxicity, accompanied by activation of thermogenic tissues and attenuation of adipose tissue inflammation, improvement of hyperglycemia and hypertriglyceridemia, and upregulation of hepatic programs involved in fatty acid oxidation and cholesterol removal. Furthermore, FGF21 inhibited hepatic inflammation, as evidenced by reduced Kupffer cell (KC) activation, diminished monocyte infiltration, and lowered accumulation of monocyte-derived macrophages. Moreover, FGF21 decreased lipid- and scar-associated macrophages, which correlated with less hepatic fibrosis as demonstrated by reduced collagen accumulation. Collectively, hepatic FGF21 overexpression limits hepatic lipotoxicity, inflammation, and fibrogenesis. Mechanistically, FGF21 blocks hepatic lipid influx and accumulation through combined endocrine and autocrine signaling, respectively, which prevents KC activation and lowers the presence of lipid- and scar-associated macrophages to inhibit fibrogenesis.
   eLife digest High-calorie modern diets have contributed to growing rates of obesity-linked diseases. One such disease is non-alcoholic steatohepatitis or NASH for short, which affects about 5% of adults in the United States. The livers of people with this condition accumulate fat, become inflamed, and develop scar tissue. People with NASH are also at increased risk of developing liver cancer, type 2 diabetes, and heart disease. Currently, no drugs are available to treat the condition and prevent such severe complications. Previous research has shown the liver produces a stress hormone, called FGF21, in response to fat accumulation. This hormone boosts fat burning and so helps to reduce excess fat in the liver. Drugs that mimic FGF21 have already been developed for type 2 diabetes. But so far, it was unclear if such drugs could also help reduce liver inflammation and scarring in patients with NASH. Liu et al. show that increasing the production of FGF21 in mice with a NASH-like condition reduces fat accumulation, liver inflammation, and scarring. In the experiments, the researchers used gene therapy to ramp up FGF21 production in the livers of mice that develop obesity and a NASH-like condition when fed a high-fat diet for 23 weeks. Increasing FGF21 production prevented the mice from developing obesity while on the high fat diet by making the body burn more fat in the liver and brown fat tissue. The treatment also reduced inflammation and prevented scarring by reducing the number and activity of immune cells in the liver. Increasing the production of the stress hormone FGF21 prevents diet-induced obesity and NASH in mice fed a high-fat diet. More studies are necessary to determine if using gene therapy to increase FGF21 may also cause weight loss and could reverse liver damage in mice that already have NASH. If this approach is effective in mice, it may be tested in humans, a process that may take several years. If human studies are successful, FGF21-boosting therapy might provide a new treatment approach for obesity or NASH.
C1 [Liu, Cong; Schonke, Milena; Spoorenberg, Borah; Zhou, Enchen; Boon, Mariëtte R.; Rensen, Patrick C. N.] Leiden Univ Med Ctr, Dept Med, Div Endocrinol, Leiden, Netherlands.
   [Liu, Cong; Schonke, Milena; Spoorenberg, Borah; Zhou, Enchen; Boon, Mariëtte R.; Rensen, Patrick C. N.] Leiden Univ Med Ctr, Einthoven Lab Expt Vasc Med, Leiden, Netherlands.
   [Lambooij, Joost M.; van der Zande, Hendrik J. P.; Guigas, Bruno] Leiden Univ Med Ctr, Dept Parasitol, Leiden, Netherlands.
   [Lambooij, Joost M.] Leiden Univ Med Ctr, Dept Cell & Chem Biol, Leiden, Netherlands.
   [Tushuizen, Maarten E.] Leiden Univ Med Ctr, Dept Gastroenterol & Hepatol, Leiden, Netherlands.
   [Andreasson, Anne-Christine; Uhrbom, Martin; Ahlstedt, Ingela; Wallenius, Kristina; Peng, Xiao-Rong] AstraZeneca, BioPharmaceut R&D, Biosci Metab Res & Early Dev Cardiovasc Renal & M, Gothenburg, Sweden.
   [Park, Andrew; Ikeda, Yasuhiro] AstraZeneca, Oncol R&D, Biol Engn & Targeted Delivery, Gaithersburg, MD USA.
   [Oldham, Stephanie] AstraZeneca, BioPharmaceut R&D, Biosci Metab Res & Early Dev Cardiovasc Renal & M, Gaithersburg, MD USA.
   [Wang, Yanan; Rensen, Patrick C. N.] Xi An Jiao Tong Univ, Affiliated Hosp 1, Med X Inst, Ctr Immunol & Metab Dis, Xian, Peoples R China.
   [Wang, Yanan; Rensen, Patrick C. N.] Xi An Jiao Tong Univ, Affiliated Hosp 1, Dept Endocrinol, Xian, Peoples R China.
C3 Leiden University; Leiden University Medical Center (LUMC); Leiden
   University; Leiden University Medical Center (LUMC); Leiden University;
   Leiden University Medical Center (LUMC); Leiden University; Leiden
   University Medical Center (LUMC); Leiden University; Leiden University
   Medical Center (LUMC); AstraZeneca; AstraZeneca; AstraZeneca; Xi'an
   Jiaotong University; Xi'an Jiaotong University
RP Boon, MR; Rensen, PC (corresponding author), Leiden Univ Med Ctr, Dept Med, Div Endocrinol, Leiden, Netherlands.; Boon, MR; Rensen, PC (corresponding author), Leiden Univ Med Ctr, Einthoven Lab Expt Vasc Med, Leiden, Netherlands.; Wang, YN; Rensen, PC (corresponding author), Xi An Jiao Tong Univ, Affiliated Hosp 1, Med X Inst, Ctr Immunol & Metab Dis, Xian, Peoples R China.; Wang, YN; Rensen, PC (corresponding author), Xi An Jiao Tong Univ, Affiliated Hosp 1, Dept Endocrinol, Xian, Peoples R China.
EM m.r.boon@lumc.nl; y_wang@xjtufh.edu.cn; p.c.n.rensen@lumc.nl
RI Boon, Mariëtte/O-3660-2016; Liu, Cong/LMO-3538-2024; van der Zande,
   Patrick/GPT-3511-2022; Schönke, Milena/HOF-1220-2023; Wang,
   Yanan/C-4143-2019
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NR 67
TC 33
Z9 35
U1 5
U2 21
PU eLIFE SCIENCES PUBL LTD
PI CAMBRIDGE
PA SHERATON HOUSE, CASTLE PARK, CAMBRIDGE, CB3 0AX, ENGLAND
SN 2050-084X
J9 ELIFE
JI eLife
PD JAN 17
PY 2023
VL 12
AR e83075
DI 10.7554/eLife.83075; 10.7554/eLife.83075.sa0; 10.7554/eLife.83075.sa1;
   10.7554/eLife.83075.sa2
PG 24
WC Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics
GA 9R9IH
UT WOS:000945960500001
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Gonciarz, M
   Gonciarz, Z
   Bielanski, W
   Mularczyk, A
   Konturek, PC
   Brzozowski, T
   Konturek, SJ
AF Gonciarz, M.
   Gonciarz, Z.
   Bielanski, W.
   Mularczyk, A.
   Konturek, P. C.
   Brzozowski, T.
   Konturek, S. J.
TI THE PILOT STUDY OF 3-MONTH COURSE OF MELATONIN TREATMENT OF PATIENTS
   WITH NONALCOHOLIC STEATOHEPATITIS: EFFECT ON PLASMA LEVELS OF LIVER
   ENZYMES, LIPIDS AND MELATONIN
SO JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
LA English
DT Article
DE nonalcoholic fatty liver disease; antioxidants; liver enzymes;
   melatonin; nonalcoholic steatohepatitis; triglycerides; cholesterol
ID FATTY LIVER; METABOLIC SYNDROME; LIFE-STYLE; VITAMIN-E; DISEASE;
   CHILDREN; THERAPY
AB The mechanism by which nonalcoholic fatty liver disease (NAFLD) progresses into nonalcoholic steatohepatitis (NASH) is unknown, however, the major process is oxidative stress with increased production of reactive oxygen species and excessive inflammatory cytokine generation. To date, there are no effective treatments for NASH and the published data with treatment using antioxidants are not satisfactory. Melatonin (MT), the potent endogenous antioxidant secreted in circadian rhythm by pinealocytes and in large amounts in the digestive system, was reported to improve oxidative status and to exert beneficial effects in NASH pathology in experimental animals, but no study attempted to determine the possible effectiveness of MT in humans with NASH. In this study, 42 patients (12 placebo controls and 30 MT-treated) with histological evidence (liver biopsy) of NASH and no history of alcohol abuse, were included. The treatment group took melatonin (2x5 mg/daily orally), while controls were treated with placebo. At baseline no significant differences between the groups were found for age, body mass index (BMI) as well as for plasma alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma-glutamyl transpeptidase (GGT), alkaline phosphatase (ALP), and concentrations of cholesterol, triglycerides (TG), glucose and MT. During the study period plasma ALT level and cholesterol concentration decreased significantly in both MT-treated and control groups, however AST and GGT levels decreased significantly only in MT-treated groups. Median value of AST level at baseline was 76.5 (64.2-114.2) IU/L and its percentage decrease at 4, 8 and 12 week was 20, 36 and 38%, resp. Baseline GGT median level was 113 (75.7-210.7) IU/L, and its mean percentage decrease at week 4, 8 and 12 was 46,48 and 47%, resp. Plasma ALP levels did not change significantly during MT treatment. Median value of plasma concentrations of MT (pg/mL) in MT-treated group rose from 7.5 (5.0-14.25) at baseline to 35.5(18.8-110.0), 43.5(17.0-102.5) and 49.5(18.0-99.5) at the end of 4, 8 and 12 week of treatment, respectively. Plasma levels of TG and glucose as well as BMI in controls and MT-treated patients were not significantly different from baseline. This study demonstrates for the first time in humans that three months treatment with MT significantly improves plasma liver enzymes in patients with NASH without causing any side-effect. Plasma MT levels during the whole period of MT treatment persisted above that at baseline. Our findings show that treatment with MT significantly improves plasma liver enzymes in NASH patients, but larger cohort trials and longer treatment with MT are required before this indole could be included into the spectrum of the NASH treatment.
C1 [Bielanski, W.; Brzozowski, T.; Konturek, S. J.] Jagiellonian Univ Med Coll, Dept Physiol, PL-31531 Krakow, Poland.
   [Gonciarz, M.; Mularczyk, A.] St Barbaras Main Dist Hosp, Dept Gastroenterol, Sosnowiec, Poland.
   [Gonciarz, Z.] Silesian Sch Management, Katowice, Poland.
   [Konturek, P. C.] Thuringia Clin Saalfeld, Dept Internal Med, Saalfeld, Germany.
C3 Jagiellonian University; Collegium Medicum Jagiellonian University
RP Konturek, SJ (corresponding author), Jagiellonian Univ Med Coll, Dept Physiol, 16 Grzegorzecka St, PL-31531 Krakow, Poland.
EM mpkontur@cyf-kr.edu.pl
RI Gonciarz, Maciej/KLZ-7377-2024
FU Polish Ministry of Science and Higher Education [K/PBW/000495]
FX This work is supported by grant No K/PBW/000495 from the Polish Ministry
   of Science and Higher Education.
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NR 36
TC 46
Z9 47
U1 0
U2 3
PU POLISH PHYSIOLOGICAL SOC
PI GRZEGORZECKA
PA JAGIELLONIAN UNIV SCHOOL MED, INST PHYSIOLOGY, 31-531 KRAKOW, 16
   GRZEGORZECKA, POLAND
SN 0867-5910
J9 J PHYSIOL PHARMACOL
JI J. Physiol. Pharmacol.
PD DEC
PY 2010
VL 61
IS 6
BP 705
EP 710
PG 6
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA 708HV
UT WOS:000286353800008
PM 21224501
DA 2025-06-11
ER

EF﻿FN Clarivate Analytics Web of Science
VR 1.0
PT J
AU Chandola, T
   Britton, A
   Brunner, E
   Hemingway, H
   Malik, M
   Kumari, M
   Badrick, E
   Kivimaki, M
   Marmot, M
AF Chandola, Tarani
   Britton, Annie
   Brunner, Eric
   Hemingway, Harry
   Malik, Marek
   Kumari, Meena
   Badrick, Ellena
   Kivimaki, Mika
   Marmot, Michael
TI Work stress and coronary heart disease: what are the mechanisms?
SO EUROPEAN HEART JOURNAL
LA English
DT Article
DE work stress; autonomic nervous system; myocardial infarction; angina;
   coronary heart disease psychosocial
ID AMBULATORY BLOOD-PRESSURE; JOB STRAIN; MYOCARDIAL-INFARCTION; METABOLIC
   SYNDROME; CARDIOVASCULAR MORTALITY; DECISION LATITUDE; RISK;
   ASSOCIATION; MEN; COUNTRIES
AB Aims To determine the biological and behavioural factors linking work stress with coronary heart disease (CHD).
   Methods and results A total of 10 308 London-based male and female civil servants aged 35-55 at phase 1 (1985-88) of the Whitehall II study were studied. Exposures included work stress (assessed at phases 1 and 2), and outcomes included behavioural risk factors (phase 3), the metabolic syndrome (phase 3), heart rate variability, morning rise in cortisol (phase 7), and incident CHD (phases 2-7) on the basis of CHD death, non-fatal myocardial infarction, or definite angina. Chronic work stress was associated with CHD and this association was stronger among participants aged under 50 (RR 1.68, 95% CI 1.17-2.42). There were similar associations between work stress and low physical activity, poor diet, the metabolic syndrome, its components, and lower heart rate variability. Cross-sectionally, work stress was associated with a higher morning rise in cortisol. Around 32% of the effect of work stress on CHD was attributable to its effect on health behaviours and the metabolic syndrome.
   Conclusion Work stress may be an important determinant of CHD among working-age populations, which is mediated through indirect effects on health behaviours and direct effects on neuroendocrine stress pathways.
C1 [Chandola, Tarani; Britton, Annie; Brunner, Eric; Hemingway, Harry; Kumari, Meena; Badrick, Ellena; Kivimaki, Mika; Marmot, Michael] UCL, Dept Epidemiol & Publ Hlth, London WC1E 6BT, England.
   [Malik, Marek] St Georges Univ London, Dept Cardiac & Vasc Sci, London, England.
C3 University of London; University College London; City St Georges,
   University of London; St Georges University London
RP Chandola, T (corresponding author), UCL, Dept Epidemiol & Publ Hlth, 1-19 Torrington Pl, London WC1E 6BT, England.
EM t.chandola@ucl.ac.uk
RI Malik, Marek/KCY-3775-2024; Brunner, Eric/H-2114-2011; Kivimaki,
   Mika/B-3607-2012; Marmot, Michael/Y-3920-2019; Hemingway,
   Harry/C-1219-2009; Chandola, Tarani/I-3192-2013
OI Marmot, Michael/0000-0002-2431-6419; Hemingway,
   Harry/0000-0003-2279-0624; Brunner, Eric/0000-0002-0595-4474; Malik,
   Marek/0000-0002-3792-1407; Chandola, Tarani/0000-0002-1864-3413; Kumari,
   Meena/0000-0001-9716-1035; Kivimaki, Mika/0000-0002-4699-5627
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NR 32
TC 435
Z9 492
U1 1
U2 91
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0195-668X
EI 1522-9645
J9 EUR HEART J
JI Eur. Heart J.
PD MAR
PY 2008
VL 29
IS 5
BP 640
EP 648
DI 10.1093/eurheartj/ehm584
PG 9
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 272AY
UT WOS:000253831100016
PM 18216031
OA Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Avitan, I
   Halperin, Y
   Saha, T
   Bloch, N
   Atrahimovich, D
   Polis, B
   Samson, AO
   Braitbard, O
AF Avitan, Iska
   Halperin, Yudit
   Saha, Trishna
   Bloch, Naamah
   Atrahimovich, Dana
   Polis, Baruh
   Samson, Abraham O.
   Braitbard, Ori
TI Towards a Consensus on Alzheimer's Disease Comorbidity?
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Review
DE Alzheimer's disease; oxidative stress; bioinformatics; comorbidity
ID OXIDATIVE STRESS; METABOLIC SYNDROME; RISK; SCHIZOPHRENIA; ANTIOXIDANTS;
   MECHANISMS; DEPRESSION; DEMENTIA; HYPOXIA; CANCER
AB Alzheimer's disease (AD) is often comorbid with other pathologies. First, we review shortly the diseases most associated with AD in the clinic. Then we query PubMed citations for the co-occurrence of AD with other diseases, using a list of 400 common pathologies. Significantly, AD is found to be associated with schizophrenia and psychosis, sleep insomnia and apnea, type 2 diabetes, atherosclerosis, hypertension, cardiovascular diseases, obesity, fibrillation, osteoporosis, arthritis, glaucoma, metabolic syndrome, pain, herpes, HIV, alcoholism, heart failure, migraine, pneumonia, dyslipidemia, COPD and asthma, hearing loss, and tobacco smoking. Trivially, AD is also found to be associated with several neurodegenerative diseases, which are disregarded. Notably, our predicted results are consistent with the previously published clinical data and correlate nicely with individual publications. Our results emphasize risk factors and promulgate diseases often associated with AD. Interestingly, the comorbid diseases are often degenerative diseases exacerbated by reactive oxygen species, thus underlining the potential role of antioxidants in the treatment of AD and comorbid diseases.
C1 [Avitan, Iska; Halperin, Yudit; Braitbard, Ori] Jerusalem Coll Technol, Bioinformat Dept, IL-9548311 Jerusalem, Israel.
   [Saha, Trishna; Bloch, Naamah; Polis, Baruh; Samson, Abraham O.] Bar Ilan Univ, Azrieli Fac Med, IL-1311502 Safed, Israel.
   [Atrahimovich, Dana] Migal Galilee Technol Ctr, Galilee Res Inst, IL-11016 Kiryat Shmona, Israel.
   [Polis, Baruh] Yale Univ, Sch Med, New Haven, CT 06520 USA.
C3 Bar Ilan University; Yale University
RP Braitbard, O (corresponding author), Jerusalem Coll Technol, Bioinformat Dept, IL-9548311 Jerusalem, Israel.
EM iskavitan@gmail.com; yudithalperin@gmail.com; trishna.saha27@gmail.com;
   naamah.bloch@biu.ac.il; dana.atr@gmail.com; baruhpolis@gmail.com;
   Avraham.Samson@biu.ac.il; orib@g.jct.ac.il
RI Polis, Baruh/AAH-7293-2020
OI Saha Detroja, Trishna/0000-0002-6951-956X; Halperin,
   Yudit/0009-0009-7378-4946; Samson, Abraham O./0000-0001-7436-3515;
   Polis, Baruh/0000-0002-3496-8250
FU Ginsburg Foundation; Katz family foundation
FX This research was funded by the Ginsburg Foundation and Katz family
   foundation to AOS.
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NR 62
TC 31
Z9 31
U1 5
U2 18
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD OCT
PY 2021
VL 10
IS 19
AR 4360
DI 10.3390/jcm10194360
PG 13
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA 0F2JJ
UT WOS:000777191400006
PM 34640387
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Sanchez-Carro, Y
   de la Torre-luque, A
   Vassou, C
   Lopez-Garcia, P
   Georgousopoulou, E
   Pitsavos, C
   Ayuso-Mateos, JL
   Panagiotakos, D
AF Sanchez-Carro, Yolanda
   de la Torre-luque, Alejandro
   Vassou, Christina
   Lopez-Garcia, Pilar
   Georgousopoulou, Ekavi
   Pitsavos, Christos
   Ayuso-Mateos, Jose Luis
   Panagiotakos, Demostenes
TI Effects of elevated emotional symptoms on metabolic disease development:
   a 10-year follow-up study
SO FRONTIERS IN PSYCHIATRY
LA English
DT Article
DE depression; anxiety; inflammation; metabolic syndrome; diabetes;
   hypertension; hypercholesterolemia
ID C-REACTIVE PROTEIN; MAJOR DEPRESSIVE DISORDER; CARDIOVASCULAR-DISEASE;
   PHYSICAL-ACTIVITY; DIABETES-MELLITUS; ANXIETY SYMPTOMS; MENTAL-ILLNESS;
   HEALTHY-ADULTS; BLOOD-PRESSURE; GREEK ADULTS
AB Background: In recent decades, the relationship between emotional disorders (i.e., depression and anxiety) and alterations in physiological functions (i.e., inflammation or metabolism) have been well supported. However, studies on a symptom-based approach have provided mixed results. Our study aims to gain insight into how subclinical statuses, featured by elevated depressive and/or anxious symptoms, may influence immunometabolic alterations in the concurrent relationship; and the development of metabolic diseases at 10-year follow-up: diabetes, hypertension and hypercholesterolemia.Methods: Data from 758 Greek adults [394 men (aged 41 +/- 10 years) and 364 women (aged 37 +/- 12 years)] were used. Four groups were created according to the levels of depressive and anxiety symptoms: (1) control group (CG), (2) depressive group (DG), (3) anxiety group (AG) and (4) depressive and anxiety group (DAG). Multi-indicator multi-causes (MIMIC) modeling was used to estimate metabolic function and inflammatory response scores, on a wide selection of blood biomarkers. Finally, a binary logistic regression was carried out to study the influence of symptoms on the development of the aforementioned metabolic diseases on a 10-year follow-up.Results Group membership was not associated with metabolic function score. Conversely, DAG membership was related with higher inflammatory response score (B = 0.20, CI95 = 0.01, 0.40), with respect to the CG (p < 0.05). Both age and sex were significant variables in the calculation of both scores. Regarding disease at 10-year follow-up effect, risk of developing diabetes, hypertension and hypercholesterolemia was associated with age and socioeconomic status. Moreover, DG membership was significant for diabetes risk (OR = 2.08, CI95 = 1.00, 4.22) and DAG for hypercholesterolemia (OR = 1.68, CI95 = 1.16, 2.43).Limitations: Data on anti-inflammatory drugs and psychopharmacological medication were not collected in this study.Conclusions: Elevated symptoms of depression and anxiety accounts for inflammatory alterations at concurrent relationship and a higher risk of 10-year follow-up metabolic diseases.
C1 [Sanchez-Carro, Yolanda; Lopez-Garcia, Pilar; Ayuso-Mateos, Jose Luis] Univ Autonoma Madrid, Dept Psychiat, Madrid, Spain.
   [Sanchez-Carro, Yolanda; Lopez-Garcia, Pilar; Ayuso-Mateos, Jose Luis] Inst Invest Sanitaria Princesa IIS Princesa, Dept Psychiat, Madrid, Spain.
   [Sanchez-Carro, Yolanda; de la Torre-luque, Alejandro; Lopez-Garcia, Pilar; Ayuso-Mateos, Jose Luis] Carlos III Hlth Inst, Ctr Biomed Res Mental Hlth CIBERSAM, Madrid, Spain.
   [de la Torre-luque, Alejandro] Univ Complutense Madrid, Dept Legal Med Psychiat & Pathol, Madrid, Spain.
   [Vassou, Christina; Georgousopoulou, Ekavi; Panagiotakos, Demostenes] Harokopio Univ, Sch Hlth Sci & Educ, Athens, Greece.
   [Pitsavos, Christos] Univ Athens, Sch Med, Cardiol Clin 1, Athens, Greece.
C3 Autonomous University of Madrid; CIBER - Centro de Investigacion
   Biomedica en Red; CIBERSAM; Complutense University of Madrid; Harokopio
   University Athens; Athens Medical School; National & Kapodistrian
   University of Athens
RP de la Torre-luque, A (corresponding author), Carlos III Hlth Inst, Ctr Biomed Res Mental Hlth CIBERSAM, Madrid, Spain.; de la Torre-luque, A (corresponding author), Univ Complutense Madrid, Dept Legal Med Psychiat & Pathol, Madrid, Spain.
EM af.delatorre@ucm.es
RI Vassou, Christina/HLX-0360-2023; Panagiotakos, Demosthenes/K-8294-2019;
   Sanchez Carro, Yolanda/AAC-9898-2022; de la Torre-Luque,
   Alejandro/AAJ-3508-2020; Georgousopoulou, Ekavi/AAC-2563-2019
OI Sanchez, Yolanda/0000-0002-8644-9436
FU Instituto de Salud Carlos III [PI20/00229]; European Regional
   Development Fund (ERDF) [FPI 2016/17]; Universidad Autonoma de Madrid
FX This study was supported by the Instituto de Salud Carlos III (grant
   ref.: PI20/00229) and co-funded by the European Regional Development
   Fund (ERDF). YS-C work was supported by the FPI pre-doctoral grant (FPI
   2016/17) from the Universidad Autonoma de Madrid.
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NR 106
TC 3
Z9 3
U1 0
U2 3
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-0640
J9 FRONT PSYCHIATRY
JI Front. Psychiatry
PD DEC 4
PY 2023
VL 14
AR 1148643
DI 10.3389/fpsyt.2023.1148643
PG 12
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA CP8B8
UT WOS:001126529800001
PM 38111613
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Vinetti, G
   Mozzini, C
   Desenzani, P
   Boni, E
   Bulla, L
   Lorenzetti, I
   Romano, C
   Pasini, A
   Cominacini, L
   Assanelli, D
AF Vinetti, Giovanni
   Mozzini, Chiara
   Desenzani, Paolo
   Boni, Enrico
   Bulla, Laura
   Lorenzetti, Isabella
   Romano, Claudia
   Pasini, Andrea
   Cominacini, Luciano
   Assanelli, Deodato
TI Supervised exercise training reduces oxidative stress and
   cardiometabolic risk in adults with type 2 diabetes: a randomized
   controlled trial
SO SCIENTIFIC REPORTS
LA English
DT Article
ID PHYSICAL-ACTIVITY; MONONUCLEAR-CELLS; GLYCEMIC CONTROL; WEIGHT-LOSS;
   FITNESS; INTERVENTION; RESISTANCE; METFORMIN; HEALTHY; PHOSPHOLIPIDS
AB To evaluate the effects of supervised exercise training (SET) on cardiometabolic risk, cardiorespiratory fitness and oxidative stress status in 2 diabetes mellitus (T2DM), twenty male subjects with T2DM were randomly assigned to an intervention group, which performed SET in a hospital-based setting, and to a control group. SET consisted of a 12-month supervised aerobic, resistance and flexibility training. A reference group of ten healthy male subjects was also recruited for baseline evaluation only. Participants underwent medical examination, biochemical analyses and cardiopulmonary exercise testing. Oxidative stress markers (1-palmitoyl-2-[5-oxovaleroyl]-sn-glycero-3-phosphorylcholine [POVPC]; 1-palmitoyl-2-glutaroyl-sn-glycero-3-phosphorylcholine [PGPC]) were measured in plasma and in peripheral blood mononuclear cells. All investigations were carried out at baseline and after 12 months. SET yielded a significant modification (p < 0.05) in the following parameters: V'O-2max (+14.4%), gas exchange threshold (+23.4%), waist circumference (-1.4%), total cholesterol (-14.6%), LDL cholesterol (-20.2%), fasting insulinemia (-48.5%), HOMA-IR (-52.5%), plasma POVPC (-27.9%) and PGPC (231.6%). After 12 months, the control group presented a V'O-2max and a gas exchange threshold significantly lower than the intervention group. Plasma POVC and PGPC were significantly different from healthy subjects before the intervention, but not after. In conclusion, SET was effective in improving cardiorespiratory fitness, cardiometabolic risk and oxidative stress status in T2DM.
C1 [Vinetti, Giovanni; Bulla, Laura; Lorenzetti, Isabella; Romano, Claudia; Assanelli, Deodato] Univ Brescia, Dept Clin & Expt Sci, Brescia, Italy.
   [Mozzini, Chiara; Pasini, Andrea; Cominacini, Luciano] Univ Verona, Sect Internal Med, Dept Med, I-37100 Verona, Italy.
   [Desenzani, Paolo] Azienda Osped Spedali Civili Brescia, Diabetol Unit, Montichiari, Italy.
   [Boni, Enrico] Azienda Osped Spedali Civili Brescia, Div Gen Med 1, Montichiari, Italy.
C3 University of Brescia; University of Verona; Hospital Spedali Civili
   Brescia; Hospital Spedali Civili Brescia
RP Vinetti, G (corresponding author), Univ Brescia, Dept Clin & Expt Sci, Brescia, Italy.
EM giovanni.vinetti@gmail.com
RI mozzini, chiara/AAW-3028-2021; cominacini, luciano/B-2775-2011; pasini,
   andrea/AAC-4906-2022; Vinetti, Giovanni/AAY-2486-2020
OI Pasini, Andrea/0000-0001-8479-8379; mozzini, chiara/0000-0002-4414-6576;
   Vinetti, Giovanni/0000-0003-4743-532X
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NR 46
TC 50
Z9 58
U1 0
U2 18
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD MAR 18
PY 2015
VL 5
AR 9238
DI 10.1038/srep09238
PG 7
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA CD6XW
UT WOS:000351235000012
PM 25783765
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Lee, YJ
   Woo, SY
   Ahn, JH
   Cho, S
   Kim, SR
AF Lee, Yu-Ji
   Woo, Sook Young
   Ahn, Joong Hyun
   Cho, Seong
   Kim, Sung Rok
TI Health-Related Quality of Life in Adults with Metabolic Syndrome: The
   Korea National Health and Nutrition Examination Survey, 2007-2008
SO ANNALS OF NUTRITION AND METABOLISM
LA English
DT Article
DE Metabolic syndrome; Quality of life; Obesity; Comorbidity
ID CORONARY-ARTERY-DISEASE; RISK-FACTOR; CARDIOVASCULAR-DISEASE; FAT
   DISTRIBUTION; FOLLOW-UP; OBESITY; OVERWEIGHT; MORTALITY; HYPERTENSION;
   ASSOCIATION
AB Background/Aims: An association between metabolic syndrome and impaired health-related quality of life (HRQoL) is still controversial. We investigated the association between metabolic syndrome in itself and HRQoL in the Korean adult population. Methods: The study is a cross-sectional analysis of 8,941 adults 6 19 years of age who participated in the 2007 and 2008 Korean National Health and Nutrition Examination Survey. EuroQoL five-dimension (EQ-5D), the EQ-5D index and the EQ visual analogue scale (EQ VAS) were used to assess HRQoL. Results: The prevalence of metabolic syndrome was 26.2%. Compared to the participants without metabolic syndrome, those with metabolic syndrome were older and comprised a higher proportion of men. Moreover, participants with metabolic syndrome were more likely to have a lower education level, to be current smokers, to have activity limitation and to have more frequent metabolic abnormalities and comorbidities. Metabolic syndrome was associated with HRQoL based on EQ-5D and EQ VAS in simple regression analysis. However, metabolic syndrome was not significantly associated with HRQoL after adjusting for age, sex, smoking status, income, education level, marital status, obesity, diabetes mellitus, stroke, history of heart disease and chronic kidney disease for EQ-5D, and in addition history of depression for EQ VAS. Conclusion: Metabolic syndrome in itself was not associated with impaired HRQoL after adjusting for confounding variables such as socio-demographic factors, medical comorbidities and obesity. Copyright (C) 2012 S. Karger AG, Basel
C1 [Lee, Yu-Ji; Cho, Seong; Kim, Sung Rok] Sungkyunkwan Univ, Sch Med, Samsung Changwon Hosp, Dept Med, Chang Won 630723, South Korea.
   [Woo, Sook Young; Ahn, Joong Hyun] Samsung Biomed Res Inst, Biostat Team, Seoul, South Korea.
C3 Sungkyunkwan University (SKKU); Samsung Medical Center; Sungkyunkwan
   University (SKKU); Samsung Medical Center
RP Kim, SR (corresponding author), Sungkyunkwan Univ, Sch Med, Samsung Changwon Hosp, Dept Med, 50 Hapseong 2 Dong, Chang Won 630723, South Korea.
EM sungrok2.kim@samsung.com
OI Ahn, Joong Hyun/0000-0002-5768-5990
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NR 38
TC 29
Z9 32
U1 0
U2 5
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0250-6807
EI 1421-9697
J9 ANN NUTR METAB
JI Ann. Nutr. Metab.
PY 2012
VL 61
IS 4
BP 275
EP 280
DI 10.1159/000341494
PG 6
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 048HX
UT WOS:000311903100002
PM 23208156
OA Bronze
DA 2025-06-11
ER

PT J
AU Messina, J
   McCall, J
   Barron, A
AF Messina, Jenn
   McCall, Jane
   Barron, Alena
TI Overweight and Obesity Status in an Urban Canadian HIV Outpatient
   Population
SO JANAC-JOURNAL OF THE ASSOCIATION OF NURSES IN AIDS CARE
LA English
DT Article
DE body mass index (BMI); Canadian; female; HIV; obesity; overweight
ID BODY-MASS INDEX; FOOD INSECURITY; ANTIRETROVIRAL THERAPY; METABOLIC
   SYNDROME; NATIONAL-HEALTH; INFECTION; INDIVIDUALS; DEPRESSION;
   PREVALENT; ADULTS
C1 [Messina, Jenn; McCall, Jane; Barron, Alena] St Pauls Hosp, HIV Program, Providence Hlth Care, Vancouver, BC V6Z 1Y6, Canada.
C3 St. Paul's Hospital
RP Messina, J (corresponding author), St Pauls Hosp, HIV Program, Providence Hlth Care, Vancouver, BC V6Z 1Y6, Canada.
FU Providence Health Care Health Practice Based Research Challenge program
FX Funding for this study was received from the Providence Health Care
   Health Practice Based Research Challenge program. Keith Chan, MSc, a
   statistician with the BC Centre for Excellence in HIV/AIDS, provided
   assistance in the preparation of this manuscript. Mentorship was
   provided by Jiak Chin Koh, MSc, RD.
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NR 25
TC 4
Z9 6
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1055-3290
EI 1552-6917
J9 J ASSOC NURSE AIDS C
JI J. Assoc. Nurses Aids Care
PD NOV-DEC
PY 2014
VL 25
IS 6
BP 652
EP 656
DI 10.1016/j.jana.2014.04.002
PG 5
WC Public, Environmental & Occupational Health; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; Nursing
GA AS7EM
UT WOS:000344420100020
PM 24840252
DA 2025-06-11
ER

PT J
AU Chico-Barba, G
   Jiménez-Limas, K
   Sánchez-Jiménez, B
   Sámano, R
   Rodríguez-Ventura, AL
   Castillo-Pérez, R
   Tolentino, M
AF Chico-Barba, Gabriela
   Jimenez-Limas, Karime
   Sanchez-Jimenez, Bernarda
   Samano, Reyna
   Lilia Rodriguez-Ventura, Ana
   Castillo-Perez, Rafael
   Tolentino, Maricruz
TI Burnout and Metabolic Syndrome in Female Nurses: An Observational Study
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Article
DE nurses; burnout; metabolic syndrome; waist circumference; emotional
   exhaustion; personal accomplishment; Mexico
ID CARDIOVASCULAR-DISEASE; NURSING PERSONNEL; RISK-FACTORS; LIFE-STYLE;
   SHIFT-WORK; HEALTH; STRESS; YOGA; PREVALENCE; ASSOCIATIONS
AB Nurses are at risk of having burnout due to workload and job stressstudies have reported that chronic stress is associated with metabolic syndrome. This study aimed to assess the association between burnout and metabolic syndrome in a sample of female nurses. Data were collected from a cross-sectional study from 2016 to 2018 in a tertiary hospital in Mexico City. All nurses that work in the hospital were invited to participate. Information pertaining to sociodemographic (age, education level), work (labor seniority, service area, shift work), anthropometric (weight, waist circumference, blood pressure) and biochemical (glucose, serum lipids) variables were collected. Burnout was assessed using the Maslach Burnout Inventory test, and metabolic syndrome was defined according to the International Diabetes Federation criteria. A total of 168 nurses participated with a median age of 44 years. The prevalence of burnout and metabolic syndrome was 19.6% and 38.7%, respectively. There was no association between burnout and metabolic syndrome (p = 0.373). However, associations of emotional exhaustion (aOR: 14.95; 95% CI: 1.5-148.7), personal accomplishment (aOR: 0.13; 95% CI: 0.01-0.99), and night shift (aOR: 12.39; 95% CI: 1.02-150.5) with increased waist circumference were found. Strategies are needed to prevent burnout and metabolic syndrome in nurses, especially in those who work at night shift.
C1 [Chico-Barba, Gabriela; Samano, Reyna; Lilia Rodriguez-Ventura, Ana; Castillo-Perez, Rafael; Tolentino, Maricruz] Inst Nacl Perinatol, Dept Nutr & Bioprogramac, Mexico City 11000, DF, Mexico.
   [Chico-Barba, Gabriela; Jimenez-Limas, Karime] Univ Panamer, Fac Ciencias Salud, Escuela Enfermeria, Mexico City 03920, DF, Mexico.
   [Sanchez-Jimenez, Bernarda] Inst Nacl Perinatol, Subdirecc Invest Intervenc Comunitarias, Mexico City 11000, DF, Mexico.
C3 Universidad Nacional Autonoma de Mexico; Universidad Panamericana -
   Ciudad de Mexico; Universidad Nacional Autonoma de Mexico
RP Jiménez-Limas, K (corresponding author), Univ Panamer, Fac Ciencias Salud, Escuela Enfermeria, Mexico City 03920, DF, Mexico.
EM gabyc3@gmail.com; 0192342@up.edu.mx; emiberna20@yahoo.com.mx;
   ssmr0119@yahoo.com.mx; rovalilia@hotmail.com;
   armando.castillo1958@gmail.com; cruz_tolentino@yahoo.com.mx
RI Sámano, Reyna/AAU-7514-2020; Chico-Barba, Gabriela/AEI-7782-2022
OI Chico-Barba, Gabriela/0000-0002-5741-0241; Jimenez-Limas,
   Karime/0000-0002-6506-8212; Sanchez-Jimenez,
   Bernarda/0000-0001-7213-0080; Samano, Reyna/0000-0001-5490-1363;
   Rodriguez-Ventura, Ana/0000-0001-8000-755X
FU Instituto Nacional de Perinatologia [212250-3300-11402-01-15]
FX This research was funded by Instituto Nacional de Perinatologia, grant
   number 212250-3300-11402-01-15.
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NR 47
TC 26
Z9 29
U1 5
U2 23
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD JUN 1
PY 2019
VL 16
IS 11
AR 1993
DI 10.3390/ijerph16111993
PG 11
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA IE1GB
UT WOS:000472132900121
PM 31195593
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Singh, M
   Singh, S
   Arora, R
   Khosla, S
AF Singh, Mukesh
   Singh, Sarabjeet
   Arora, Rohit
   Khosla, Sandeep
TI Cardiac syndrome X: Current concepts
SO INTERNATIONAL JOURNAL OF CARDIOLOGY
LA English
DT Review
DE Angina; Cardiac syndrome X; Pathophysiology; Management
ID NORMAL CORONARY-ARTERIES; ELECTRICAL NERVE-STIMULATION;
   COGNITIVE-BEHAVIORAL THERAPY; LEFT-VENTRICULAR FUNCTION; ST SEGMENT
   DEPRESSION; C-REACTIVE PROTEIN; CHEST-PAIN; ANGINA-PECTORIS;
   MYOCARDIAL-INFARCTION; ENDOTHELIAL FUNCTION
AB Cardiac syndrome X is a heterogeneous entity, both clinically and pathophysiologically, encompassing a variety of pathogenic mechanisms. Management of this syndrome represents a major challenge to the treating physician. They often seek medical care because of recurring and disabling chest pain, which may imply repetitive and costly invasive and non-invasive investigations. A careful patient evaluation for underlying pathophysiologic mechanism and exclusion of other causes of chest pain along with attention to various psychological aspects is helpful in reducing the stress and suffering of these patients. This article reviews the available literature on the pathophysiology and current controversies surrounding the management of this difficult to treat condition. (C) 2009 Published by Elsevier Ireland Ltd.
C1 [Singh, Mukesh; Singh, Sarabjeet; Arora, Rohit; Khosla, Sandeep] Rosalind Franklin Univ Med & Sci, Chicago Med Sch, Dept Internal Med, N Chicago, IL 60064 USA.
C3 Rosalind Franklin University of Medicine & Science; Chicago Medical
   School
RP Singh, M (corresponding author), Rosalind Franklin Univ Med & Sci, Chicago Med Sch, Dept Internal Med, N Chicago, IL 60064 USA.
EM drmukeshsingh@yahoo.com
RI Singh, Mukesh/A-5759-2009
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   van Peski-Oosterbaan AS, 1999, AM J MED, V106, P424, DOI 10.1016/S0002-9343(99)00049-2
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NR 106
TC 45
Z9 48
U1 0
U2 3
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0167-5273
EI 1874-1754
J9 INT J CARDIOL
JI Int. J. Cardiol.
PD JUL 9
PY 2010
VL 142
IS 2
BP 113
EP 119
DI 10.1016/j.ijcard.2009.11.021
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 609JJ
UT WOS:000278652200002
PM 20138677
DA 2025-06-11
ER

PT J
AU Coplan, JD
   Abdallah, CG
   Mathew, SJ
   Shungu, DC
   Mao, XL
   Smith, ELP
   Kaufman, D
   Gorman, JM
   Owens, MJ
   Nemeroff, CB
   Banerji, MA
   Rosenblum, LA
   Kral, JG
AF Coplan, Jeremy D.
   Abdallah, Chadi G.
   Mathew, Sanjay J.
   Shungu, Dikoma C.
   Mao, Xiangling
   Smith, Eric L. P.
   Kaufman, Daniel
   Gorman, Jack M.
   Owens, Michael J.
   Nemeroff, Charles B.
   Banerji, Mary Ann
   Rosenblum, Leonard A.
   Kral, John G.
TI Metabolic syndrome and neurometabolic asymmetry of hippocampus in adult
   bonnet monkeys
SO PHYSIOLOGY & BEHAVIOR
LA English
DT Article
DE Corticotropin releasing factor; Hippocampus; Stress; Metabolic syndrome;
   Food insecurity; Obesity
ID CORTICOTROPIN-RELEASING-FACTOR; CEREBROSPINAL-FLUID CONCENTRATIONS;
   MAGNETIC-RESONANCE-SPECTROSCOPY; BODY-WEIGHT REGULATION; EARLY-LIFE
   STRESSORS; NONHUMAN-PRIMATES; OBESITY; ENERGY; MEMORY; BRAIN
AB Objective: Obesity is associated with the insulin resistance metabolic syndrome, postulated to be mediated by stress-induced alterations within the hypothalamic-pituitary-adrenal (HPA) axis. In adult bonnet macaques we examined relationships between components of the metabolic syndrome, hippocampal neurometabolic asymmetry, an indicator of negative affect, and juvenile cerebrospinal fluid (csf) corticotropin-releasing factor (CRF) levels obtained after stress exposure associated with maternal food insecurity and in controls.
   Methods: Eleven adult male monkeys (seven with early life stress) who had undergone csf-CRF analyses as juveniles had magnetic resonance spectroscopic imaging (MRSI) of bilateral hippocampus, morphometry (body mass index, BMI: sagittal abdominal diameter, SAD) and determination of fasting plasma glucose and insulin as adults. Neurometabolite ratios included N-acetyl-aspartate as numerator (NAA; a marker of neuronal integrity) and choline (Cho; cell turnover) and creatine (Cr; reference analyte) as denominators.
   Results: Elevated juvenile csf-CRF levels positively predicted adult BMI and SAD and were associated with right > left shift of NAA ratio within the hippocampus. Adult visceral obesity and insulin level correlated with right > left shift in hippocampal NAA concentrations, controlling for age and denominator.
   Conclusion: Juvenile csf-CRF levels, a neuropeptide associated with early life stress, predict adult visceral obesity and hippocampal asymmetry supporting the hypothesis that metabolic syndrome in adults may be related to early life stress. Furthermore, this study demonstrates asymmetrical hippocampal alterations related to obesity. (C) 2011 Elsevier Inc. All rights reserved.
C1 [Coplan, Jeremy D.; Abdallah, Chadi G.; Smith, Eric L. P.; Rosenblum, Leonard A.] Suny Downstate Med Ctr, Primate Behav Lab, Dept Psychiat, Brooklyn, NY 11203 USA.
   [Coplan, Jeremy D.] Columbia Univ Coll Phys & Surg, New York State Psychiat Inst, Dept Geriatr Psychiat, New York, NY 10032 USA.
   [Mathew, Sanjay J.] Baylor Coll Med, Dept Psychiat & Behav Sci, Houston, TX 77030 USA.
   [Shungu, Dikoma C.; Mao, Xiangling] Cornell Univ, Weill Med Coll, Dept Radiol, New York, NY 10021 USA.
   [Shungu, Dikoma C.; Mao, Xiangling] Cornell Univ, Weill Med Coll, Dept Psychiat & Biophys, New York, NY 10021 USA.
   [Kaufman, Daniel; Kral, John G.] Suny Downstate Med Ctr, Dept Surg, Brooklyn, NY 11203 USA.
   [Gorman, Jack M.] Comprehens NeuroSci Inc, White Plains, NY USA.
   [Owens, Michael J.] Emory Univ, Sch Med, Dept Psychiat & Behav Sci, Atlanta, GA USA.
   [Nemeroff, Charles B.] Univ Miami, Miller Sch Med, Dept Psychiat & Behav Sci, Miami, FL 33136 USA.
   [Banerji, Mary Ann] Suny Downstate Med Ctr, Dept Med, Brooklyn, NY 11203 USA.
C3 State University of New York (SUNY) System; SUNY Downstate Health
   Sciences University; Columbia University; New York State Psychiatry
   Institute; Baylor College of Medicine; Baylor College Medical Hospital;
   Cornell University; Weill Cornell Medicine; Cornell University; Weill
   Cornell Medicine; State University of New York (SUNY) System; SUNY
   Downstate Health Sciences University; Emory University; University of
   Miami; State University of New York (SUNY) System; SUNY Downstate Health
   Sciences University
RP Coplan, JD (corresponding author), Suny Downstate Med Ctr, Primate Behav Lab, Dept Psychiat, Box 120,450 Clarkson Ave, Brooklyn, NY 11203 USA.
EM Copstat00@aol.com
RI Mathew, Sanjay/J-2830-2014; Nemeroff, Charles/AEU-9195-2022; smith,
   Eric/KGL-0324-2024; Shungu, Dikoma/H-7110-2019; Owens,
   Michael/G-5191-2012; Abdallah, Chadi/M-9969-2017
OI Abdallah, Chadi/0000-0001-5783-6181; Shungu, Dikoma
   C/0000-0001-9452-2245; Nemeroff, Charles/0000-0001-7867-1160
FU National Institute of Mental Health [MH 59990, MH 58911, T32-MH15144];
   National Alliance for Research on Schizophrenia and Depression;
   Psychiatric Institute Research Support Grant; Smart Family Foundation
FX Research supported by: the National Institute of Mental Health Grant
   nos. MH 59990 and MH 58911 (JDC); the National Alliance for Research on
   Schizophrenia and Depression Mid-Investigator Award (JDC); the National
   Alliance for Research on Schizophrenia and Depression Young
   Investigator's Award (SJM); Psychiatric Institute Research Support Grant
   and by the National Institute of Mental Health research fellowship
   T32-MH15144 (SJM); and The Smart Family Foundation (JGK).
CR Abbott DH, 2003, HORM BEHAV, V43, P67, DOI 10.1016/S0018-506X(02)00037-5
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NR 33
TC 4
Z9 4
U1 0
U2 6
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0031-9384
J9 PHYSIOL BEHAV
JI Physiol. Behav.
PD JUL 6
PY 2011
VL 103
IS 5
BP 535
EP 539
DI 10.1016/j.physbeh.2011.03.020
PG 5
WC Psychology, Biological; Behavioral Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Behavioral Sciences
GA 788VA
UT WOS:000292471300016
PM 21459102
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Hernández, EAG
   Cobos, DS
   Valle, MDG
   Flores, JDB
   Chávez, RS
   Mondragón, LD
   Guerrero, GAM
   Sánchez, PL
AF Guzman Hernandez, Elizabeth Alejandrina
   Segura Cobos, David
   Gonzalez Valle, Maria del Rosario
   Benitez Flores, Jose del Carmen
   Miguel Chavez, Ruben San
   del Valle Mondragon, Leonardo
   Magos Guerrero, Gil Alfonso
   Lopez Sanchez, Pedro
TI Antihypertensive, antidyslipidemic, and renoprotective effects of
   Bursera simaruba on metabolic syndrome
SO IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
LA English
DT Article
DE Blood pressure; Bursera simaruba; Hyperlipidemia; Kidney failure;
   Metabolic syndrome; Obesity; Oxidative stress
ID OXIDATIVE STRESS; FRUCTOSE; DYSLIPIDEMIA; INFLAMMATION; EXTRACTS;
   CURCUMIN; LIPIDS; RATS
AB Objective(s): Metabolic syndrome is associated with the development of chronic kidney disease. Bursera simaruba "chaca" is a medicinal plant used in Mexico for hypertension and empirical therapy. In this study, were examined the effects of ethanol extract of B. simaruba on metabolic syndrome.Materials and Methods: For induction of metabolic syndrome, 20% fructose was used, and it was administered in the water and food to male Wistar rats for 12 weeks, after administering ethanol extract of B. simaruba intragastrically (100 and 200 mg/kg/day) for 6 weeks, blood pressure was determined. In plasma, glucose, cholesterol, triglycerides, angiotensin II, oxide nitric, and angiotensin 1-7 were quantified. In the kidney was performed histological study and the activity of anti-oxidant enzymes was quantified.Results: Rats with metabolic syndrome developed obesity, arterial hypertension, dyslipidemia, and kidney damage characterized by proliferative glomerulonephritis, necrosis, and reduced activity of anti-oxidant enzymes. These alterations were significantly ameliorated by ethanol extract of B. simaruba.Conclusion: The ethanolic extract of B. simaruba showed antidyslipidemic, antihypertensive, anti-oxidant, and renoprotective effects.
C1 [Guzman Hernandez, Elizabeth Alejandrina; Segura Cobos, David] Univ Nacl Autonoma Mexico, Fac Super Studies Iztacala, Tlalnepantla 54090, State Of Mexico, Mexico.
   [Gonzalez Valle, Maria del Rosario; Benitez Flores, Jose del Carmen] Univ Nacl Autonoma Mexico, Fac Super Studies Iztacala, Morphol & Funct Unit, Histol Lab, Tlalnepantla 54090, State Of Mexico, Mexico.
   [Miguel Chavez, Ruben San] Postgrad Coll, Phytochem Area, Postgrad Degree Bot, Campus Montecillo,Km 36-5 Mexico Texcoco Rd, Texcoco 56230, State Of Mexico, Mexico.
   [del Valle Mondragon, Leonardo] Natl Inst Cardiol Ignacio Chavez, Dept Pharmacol, Mexico City 04510, Mexico.
   [Magos Guerrero, Gil Alfonso] Univ Nacl Autonoma Mexico, Fac Med, Dept Pharmacol, Mexico City 04510, Mexico.
   [Lopez Sanchez, Pedro] Natl Polytech Inst, Higher Sch Med, Postgrad Studies & Res Sect, Mexico City 11340, Mexico.
C3 Universidad Nacional Autonoma de Mexico; Universidad Nacional Autonoma
   de Mexico; National Institute of Cardiology - Mexico; Universidad
   Nacional Autonoma de Mexico; Instituto Politecnico Nacional - Mexico
RP Hernández, EAG (corresponding author), Univ Nacl Autonoma Mexico, Fac Super Studies Iztacala, Tlalnepantla 54090, State Of Mexico, Mexico.
EM shponia2000@yahoo.com.mx
RI valle, maria/KII-1654-2024
CR Ajiboye TO, 2016, J SCI FOOD AGR, V96, P1522, DOI 10.1002/jsfa.7254
   Ajiboye TO, 2014, J BIOCHEM MOL TOXIC, V28, P558, DOI 10.1002/jbt.21598
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   Tenorio-López FA, 2010, TALANTA, V80, P1702, DOI 10.1016/j.talanta.2009.10.010
   Magos-Guerrero GA, 2017, J INTERCULT ETHNOPHA, V6, P274, DOI 10.5455/jice.20170706061922
   Bratoeva K, 2017, CUREUS J MED SCIENCE, V7, P1826
   Cho AS, 2010, FOOD CHEM TOXICOL, V48, P937, DOI 10.1016/j.fct.2010.01.003
   Fernandez A, 2019, J CLIN MED, V23, P345
   Huptas S, 2006, AM J CARDIOL, V98, P66, DOI 10.1016/j.amjcard.2006.01.055
   Kotsis V, 2010, HYPERTENS RES, V33, P386, DOI 10.1038/hr.2010.9
   Ku HK, 2013, ANAL BIOCHEM, V434, P178, DOI 10.1016/j.ab.2012.10.045
   Lam D. W., 2019, METABOLIC SYNDROME
   Maldini M, 2009, PHYTOCHEMISTRY, V70, P641, DOI 10.1016/j.phytochem.2009.02.009
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   Oboh G, 2019, J DIET SUPPL, V16, P105, DOI 10.1080/19390211.2018.1438553
   Oyinloye BE, 2016, PHARMACOGN MAG, V12, pS170, DOI 10.4103/0973-1296.182155
   Palanisamy N, 2008, RENAL FAILURE, V30, P645, DOI 10.1080/08860220802134532
   Patil CR, 2010, PHYTOTHER RES, V24, P33, DOI 10.1002/ptr.2861
   Prince PSM, 2012, FOOD RES INT, V45, P155, DOI 10.1016/j.foodres.2011.10.009
   Rajasekar P, 2008, DIABETES OBES METAB, V10, P171, DOI 10.1111/j.1463-1326.2007.00825.x
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   Ugur S, 2015, RENAL FAILURE, V37, P332, DOI 10.3109/0886022X.2014.986005
NR 26
TC 2
Z9 2
U1 1
U2 6
PU MASHHAD UNIV MED SCIENCES
PI MASHHAD
PA VICE-CHANCELLOR FOR RES CTR OFF IJBMS, DANESHGAH ST, PO BOX 9138813944 -
   445, MASHHAD, 00000, IRAN
SN 2008-3866
EI 2008-3874
J9 IRAN J BASIC MED SCI
JI Iran. J. Basic Med. Sci.
PD APR
PY 2023
VL 26
IS 4
BP 414
EP 419
DI 10.22038/IJBMS.2023.66530.14601
PG 6
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA H3ZO0
UT WOS:000995383400004
PM 37009005
DA 2025-06-11
ER

PT J
AU Moribe, R
   Minami, M
   Hirota, R
   Awn, JPN
   Kabayama, S
   Eitoku, M
   Yamasaki, K
   Kuroiwa, H
   Suganuma, N
AF Moribe, Reiko
   Minami, Marina
   Hirota, Ryoji
   Awn, J-p Naw
   Kabayama, Shigeru
   Eitoku, Masamitsu
   Yamasaki, Keiko
   Kuroiwa, Hajime
   Suganuma, Narufumi
TI Health Effects of Electrolyzed Hydrogen Water for the Metabolic Syndrome
   and Pre-Metabolic Syndrome: A 3-Month Randomized Controlled Trial and
   Subsequent Analyses
SO ANTIOXIDANTS
LA English
DT Article
DE electrolyzed hydrogen water; metabolic syndrome; waist circumference;
   physical activity; oxidative stress
ID MILD COGNITIVE IMPAIRMENT; OXIDATIVE STRESS; RICH WATER; INFLAMMATION;
   BLOOD; ANTIOXIDANT; BIOMARKERS; EXERCISE; DISEASE; BIOLOGY
AB We studied the effect of three months' use of electrolyzed hydrogen water (EHW, Electrolyzed Hydrogen Water conditioner produced by Nihon Trim Co., Ltd.) on metabolic and pre-metabolic syndrome groups. This research was carried out jointly by Susaki City; Nihon Trim Co., Ltd.; and Kochi University as part of a local revitalization project with health as a keyword. A randomized, placebo-controlled, double-blind, parallel-group trial was conducted to evaluate the clinical impact of EHW on participants who suffered from metabolic syndrome or pre-metabolic syndrome. EHW was produced via electrolysis using a commercially available apparatus (Nihon Trim Co., Ltd., Osaka, Japan). During exercise, oxidative stress increases, and active oxygen species increase. In this study, we examined 181 subjects with metabolic syndrome or pre-metabolic syndrome. Among the group that drank EHW for 3 months, those who also engaged in a high level of physical activity showed a significant difference in waist circumference reduction. Although no significant difference was observed, several positive results were found in the participants who engaged in a high level of physical activity. Urinary 8-OHdG, urinary nitrotyrosine, HbA1c, and blood glucose levels increased in the filtered water (FW) group but decreased in the EHW group. High-sensitivity CRP increased less in the EHW group. 8-Isoprostane decreased more in the EHW group. In subgroup analysis, the EHW group showed a significantly greater reduction in waist circumference than the FW group only when controlled for high physical activity. Based on the result, we suggest that, among participants in the study who suffered from metabolic syndrome and pre-metabolic syndrome in which the level of active oxygen species is said to be higher than in healthy subjects, the group that consumed EHW and also engaged in a high level of physical activity experienced a suppressed or reduced increase in active oxygen species.
C1 [Moribe, Reiko; Minami, Marina; Hirota, Ryoji; Awn, J-p Naw; Eitoku, Masamitsu; Yamasaki, Keiko; Suganuma, Narufumi] Kochi Univ, Kochi Med Sch, Dept Environm Med, Nankoku 7838505, Japan.
   [Minami, Marina; Kuroiwa, Hajime] Kochi Univ, Kochi Med Sch, Integrated Ctr Adv Med Technol ICAM Tech, Nankoku 7838505, Japan.
   [Hirota, Ryoji] Matsumoto Univ, Grad Sch Hlth Sci, Matsumoto 3901295, Japan.
   [Kabayama, Shigeru] Nihon Trim Co Ltd, 22F Herbis ENT Off Tower,2-2-22 Umeda,Kita Ku, Osaka 5300001, Japan.
   [Kabayama, Shigeru] Kobe Univ, Grad Sch Sci Technol & Innovat, 1-1 Rokkoudai Cho Nada Ku, Kobe 6578501, Japan.
C3 Kochi University; Kochi University; Kobe University
RP Minami, M (corresponding author), Kochi Univ, Kochi Med Sch, Dept Environm Med, Nankoku 7838505, Japan.; Minami, M (corresponding author), Kochi Univ, Kochi Med Sch, Integrated Ctr Adv Med Technol ICAM Tech, Nankoku 7838505, Japan.
EM reikojuriana@gmail.com; marina.minami@kochi-u.ac.jp;
   ryoji.hirota@t.matsu.ac.jp; jpnawawn@kochi-u.ac.jp;
   kabayama@nihon-trim.co.jp; meitoku@kochi-u.ac.jp;
   jm-keiko-yamasaki@kochi-u.ac.jp; kuroiwa-hajime@kochi-u.ac.jp;
   nsuganuma@kochi-u.ac.jp
RI kabayama, shigeru/MFH-2923-2025
OI Minami, Marina/0000-0003-4651-5061
FU Nihon Trim Co., Ltd.; Grants-in-Aid for Scientific Research [22K11063]
   Funding Source: KAKEN
FX The authors are greatly indebted to the Municipality of Susaki City Hall
   for their collaborative efforts in recruiting participants for this
   study.
CR [Anonymous], Physical Activity for Visceral Fat Reduction
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NR 34
TC 1
Z9 1
U1 2
U2 8
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD FEB
PY 2024
VL 13
IS 2
AR 145
DI 10.3390/antiox13020145
PG 14
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA IY6V3
UT WOS:001169949000001
PM 38397743
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Soreca, I
   Frank, E
   Kupfer, DJ
AF Soreca, Isabella
   Frank, Ellen
   Kupfer, David J.
TI THE PHENOMENOLOGY OF BIPOLAR DISORDER: WHAT DRIVES THE HIGH RATE OF
   MEDICAL BURDEN AND DETERMINES LONG-TERM PROGNOSIS?
SO DEPRESSION AND ANXIETY
LA English
DT Review
DE bipolar disorder; comorbidity; depression; cardiovascular diseases;
   anxiety; cognitive symptoms
ID MAJOR AFFECTIVE-DISORDERS; WEEKLY SYMPTOMATIC STATUS; SOCIAL RHYTHM
   DISRUPTION; PITUITARY-ADRENAL AXIS; STRESSFUL LIFE EVENTS;
   PSYCHIATRIC-DISORDERS; I DISORDER; METABOLIC SYNDROME;
   DIABETES-MELLITUS; NEUROPSYCHOLOGICAL PERFORMANCE
AB Bipolar disorder (BD) has been classically described as one of episodic mood disturbances. New evidence suggests that a chronic course and multisystem, involvement is the rule, rather than the exception, and that together with disturbances of circadian rhythms, mood instability, cognitive impairment, a high rate of medical burden is often observed. The current diagnostic approach for BD neither describes the multisystem involvement that the recent literature has highlighted nor points toward potential predictors of long-term outcome. In light of the new evidence that the long-term course of BD is associated with a high prevalence of psychiatric comorbidity and an increased mortality from medical disease, we propose a multidimensional approach that includes several symptom domains, namely affective instability, circadian rhythm dysregulation, and cognitive and executive dysfunction, presenting in various combinations that give shape to each individual presentation, and offers potential indicators of overall long. term prognosis. Depression and Anxiety 26.73-82, 2009. (c) 2008 Wiky-Liss, Inc.
C1 [Soreca, Isabella; Frank, Ellen; Kupfer, David J.] Univ Pittsburgh, Western Psychiat Inst & Clin, Dept Psychiat, Pittsburgh, PA 15213 USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE); University
   of Pittsburgh; Western Psychiatric Institute & Clinic of UPMC
RP Soreca, I (corresponding author), Univ Pittsburgh, Western Psychiat Inst & Clin, Dept Psychiat, WPIC-BT 807A,3811 OHara St, Pittsburgh, PA 15213 USA.
EM sorecai@upmc.edu
FU NIMH NIH HHS [R01 MH081003] Funding Source: Medline
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NR 117
TC 67
Z9 81
U1 0
U2 13
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1091-4269
EI 1520-6394
J9 DEPRESS ANXIETY
JI Depress. Anxiety
PD JAN
PY 2009
VL 26
IS 1
BP 73
EP 82
DI 10.1002/da.20521
PG 10
WC Psychology, Clinical; Psychiatry; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA 390EN
UT WOS:000262147200011
PM 18828143
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Hernández-González, M
   Solorio, S
   Solís-Jiménez, MC
   Rodríguez-Mariscal, L
   Murillo-Ortíz, B
   Vazquez-Olvera, S
AF Hernandez-Gonzalez, Martha
   Solorio, Sergio
   Crisostomo Solis-Jimenez, Manuel
   Rodriguez-Mariscal, Leticia
   Murillo-Ortiz, Blanca
   Vazquez-Olvera, Sergio
TI PROGNOSTIC VALUE OF DOBUTAMINE STRESS ECHOCARDIOGRAPHY IN PREDICTING
   MAJOR CARDIAC EVENTS IN PATIENTS WITH METABOLIC SYNDROME
SO REVISTA DE INVESTIGACION CLINICA-CLINICAL AND TRANSLATIONAL
   INVESTIGATION
LA English
DT Article
DE Dobutamine echo test; Metabolic syndrome; Coronary artery disease;
   Diagnostic test
ID ACUTE MYOCARDIAL-INFARCTION; DIABETES-MELLITUS; CARDIOVASCULAR-DISEASE;
   ASSOCIATION; TOMOGRAPHY; MORTALITY; CRITERIA; HEALTH; RISK; BIAS
AB Background: The metabolic syndrome increases cardiovascular mortality. We report the mid-tent prognostic value of dobutamine echocardiography for metabolic syndrome. Patients and methods: A dobutamine echocardiography protocol was performed in patients aged 18 years of age or older who suffered from chest pain and who were followed-up for two years. The patients were divided in two groups, with and without metabolic syndrome. Statistical analyses were performed using ROC curves and survival analysis; the Begg-Greenes method was used to correct for verification bias. We included 128 patients, 66 with metabolic syndrome and 62 without. Results: Forty-one patients with metabolic syndrome and 36 without had positive dobutamine echocardiography test results (p = 0.77). Coronary artery disease was found in 27 patients with metabolic syndrome and in 29 without metabolic syndrome; percutaneous revascularization was required in 24 and 26 patients, respectively (p = 0.29). Cardiovascular events occurred in 28 patients during follow-up (19 in metabolic syndrome vs. 9 in non-metabolic syndrome; p = 0.17). The odds ratio of major cardiovascular events in the metabolic syndrome group was 5.8 (95% Cl: 1.74-19.60); in the control group it was 8.6 (95% Cl: 2.53-29.59). Conclusion: Dobutamine echocardiography for metabolic syndrome has high sensitivity but is not a determining factor for mid-term prognosis.
C1 [Hernandez-Gonzalez, Martha] IMSS, Hosp Gen Zona 21, Dept Internal Med, Leon, Guanajuato, Mexico.
   [Solorio, Sergio; Crisostomo Solis-Jimenez, Manuel; Murillo-Ortiz, Blanca; Vazquez-Olvera, Sergio] IMSS, Unidad Med Alta Especialidad 1, Clin Res Unit, Leon, Guanajuato, Mexico.
   [Rodriguez-Mariscal, Leticia] IMSS, Unidad Med Alta Especialidad 1, Dept Cardiol, Leon, Guanajuato, Mexico.
RP Hernández-González, M (corresponding author), IMSS, Hosp Gen Zona 21, Dept Internal Med, Coral 101, Leon, Guanajuato, Mexico.
EM martha_hdz@hotmail.com
RI Ortiz, Blanca/ABD-4523-2020; Hernandez-Gonzalez, Martha/AAH-6053-2020
OI Hernandez-Gonzalez, Martha A./0000-0002-6903-2233
FU Consejo Nacional de Ciencia y Tecnologia del Estado de Guanajuato
   (CONCYTEG) [09-38-K662-091]
FX This study and/or authorship was supported by a grant from the Consejo
   Nacional de Ciencia y Tecnologia del Estado de Guanajuato (CONCYTEG,
   grant number 09-38-K662-091).
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NR 26
TC 0
Z9 0
U1 0
U2 0
PU INST NACIONAL NUTRICION
PI MEXICO
PA VASCO DE QUIROZA 15, COLONIA SECCION XVI, TLALPAN, MEXICO 14000 D F,
   MEXICO
SN 0034-8376
EI 2564-8896
J9 REV INVEST CLIN
JI Rev. Investig. Clin.
PD MAY-JUN
PY 2015
VL 67
IS 3
BP 199
EP 206
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA CN4HZ
UT WOS:000358392500007
PM 26202744
DA 2025-06-11
ER

PT J
AU García-Arroyo, FE
   Gonzaga-Sánchez, G
   Silva-Palacios, A
   Roldán, FJ
   Loredo-Mendoza, ML
   Alvarez-Alvarez, YQ
   Coyotl, JAD
   Orozco, KAV
   Tapia, E
   Osorio-Alonso, H
   Arellano-Buendía, AS
   Sánchez-Gloria, JL
   Lanaspa, MA
   Johnson, RJ
   Sánchez-Lozada, LG
AF Garcia-Arroyo, Fernando E. E.
   Gonzaga-Sanchez, Guillermo
   Silva-Palacios, Alejandro
   Roldan, Francisco Javier
   Loredo-Mendoza, Maria L.
   Alvarez-Alvarez, Yamnia Quetzal
   de los Santos Coyotl, Jesus A. A.
   Orozco, Kevin A. Velez A.
   Tapia, Edilia
   Osorio-Alonso, Horacio
   Arellano-Buendia, Abraham S. S.
   Sanchez-Gloria, Jose L.
   Lanaspa, Miguel A. A.
   Johnson, Richard J. J.
   Sanchez-Lozada, Laura Gabriela
TI Osthole Prevents Heart Damage Induced by Diet-Induced Metabolic
   Syndrome: Role of Fructokinase (KHK)
SO ANTIOXIDANTS
LA English
DT Article
DE cardiac hypertrophy; polyol pathway; hyperuricemia
ID FRUCTOSE; GLUTATHIONE; MEDIATORS
AB There is increasing evidence that either ingested or produced fructose may have a role in metabolic syndrome. While not commonly considered a criterion for metabolic syndrome, cardiac hypertrophy is often associated with metabolic syndrome, and its presence carries increased cardiovascular risk. Recently it has been shown that fructose and fructokinase C (KHK) can be induced in cardiac tissue. Here we tested whether diet-induced metabolic syndrome causes heart disease associated with increased fructose content and metabolism and whether it can be prevented with a fructokinase inhibitor (osthole). Male Wistar rats were provided a control diet (C) or high fat/sugar diet for 30 days (MS), with half of the latter group receiving osthol (MS+OT, 40 mg/kg/d). The Western diet increased fructose, uric acid, and triglyceride concentrations in cardiac tissue associated with cardiac hypertrophy, local hypoxia, oxidative stress, and increased activity and expression of KHK in cardiac tissue. Osthole reversed these effects. We conclude that the cardiac changes in metabolic syndrome involve increased fructose content and its metabolism and that blocking fructokinase can provide cardiac benefit through the inhibition of KHK with modulation of hypoxia, oxidative stress, hypertrophy, and fibrosis.
C1 [Garcia-Arroyo, Fernando E. E.; Gonzaga-Sanchez, Guillermo; Alvarez-Alvarez, Yamnia Quetzal; de los Santos Coyotl, Jesus A. A.; Orozco, Kevin A. Velez A.; Tapia, Edilia; Osorio-Alonso, Horacio; Arellano-Buendia, Abraham S. S.; Sanchez-Gloria, Jose L.; Sanchez-Lozada, Laura Gabriela] Inst Nacl Cardiol Ignacio Chavez, Dept Cardiorenal Physiopathol, Mexico City 14080, DF, Mexico.
   [Silva-Palacios, Alejandro] Inst Nacl Cardiol Ignacio Chavez, Dept Cardiovasc Biomed, Mexico City 14080, DF, Mexico.
   [Roldan, Francisco Javier] Inst Nacl Cardiol Ignacio Chavez, Dept External Consultat, Mexico City 14080, DF, Mexico.
   [Loredo-Mendoza, Maria L.] Inst Nacl Cardiol Ignacio Chavez, Dept Pathol, Mexico City 14080, DF, Mexico.
   [Lanaspa, Miguel A. A.; Johnson, Richard J. J.] Univ Colorado, Renal Dis & Hypertens, Aurora, CO 80045 USA.
C3 National Institute of Cardiology - Mexico; National Institute of
   Cardiology - Mexico; National Institute of Cardiology - Mexico; National
   Institute of Cardiology - Mexico; University of Colorado System;
   University of Colorado Anschutz Medical Campus
RP García-Arroyo, FE; Sánchez-Lozada, LG (corresponding author), Inst Nacl Cardiol Ignacio Chavez, Dept Cardiorenal Physiopathol, Mexico City 14080, DF, Mexico.
EM enrique.garcia@cardiologia.org.mx
RI Silva-Palacios, Alejandro/JCD-8759-2023; Alonso, Horacio/T-3946-2019;
   Sanchez-Lozada, Laura/AAS-2104-2021
OI Osorio Alonso, Horacio/0000-0002-9238-4202; Silva-Palacios,
   Alejandro/0000-0002-8409-7967; Sanchez-Lozada,
   Laura-Gabriela/0000-0003-0348-9617; ROLDAN,
   FRANCISCO-JAVIER/0000-0003-4726-0048; Sanchez Gloria, Jose
   Luis/0000-0002-2077-7007
FU CONACyT Mexico [1164561]
FX The APC was funded by Instituto Nacional de Cardiologia Ignacio Chavez.
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NR 29
TC 3
Z9 3
U1 4
U2 9
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD APR 28
PY 2023
VL 12
IS 5
AR 1023
DI 10.3390/antiox12051023
PG 15
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA H2FK4
UT WOS:000994172400001
PM 37237888
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Veltman, EM
   Lamers, F
   Comijs, HC
   de Waal, MWM
   Stek, ML
   van der Mast, RC
   Rhebergen, D
AF Veltman, E. M.
   Lamers, F.
   Comijs, H. C.
   de Waal, M. W. M.
   Stek, M. L.
   van der Mast, R. C.
   Rhebergen, D.
TI Depressive subtypes in an elderly cohort identified using latent class
   analysis
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Latent class analysis; Depression subtypes; Atypical depression;
   Melancholic depression; Metabolic syndrome
ID ATYPICAL DEPRESSION; OLDER-ADULTS; PSYCHOMETRIC PROPERTIES; COMMUNITY
   SAMPLE; SAO-PAULO; SYMPTOMS; HEALTH; POPULATION; DISORDER; FRAILTY
AB Background: Clinical findings indicate. heterogeneity of depressive disorders, stressing the importance of subtyping depression for research and clinical care. Subtypes of the common late life depression are however seldom studied. Data-driven methods may help provide a more empirically-based classification of late-life depression.
   Methods: Data were used from the Netherlands Study of Depression in Older People (NESDO) derived from 359 persons, aged 60 years or older, with a current diagnosis of major depressive disorder. Latent class analysis (LCA) was used to identify subtypes of depression, using ten CIDI-based depression items. Classes were then characterized using various sociodemographic and clinical characteristics.
   Results: The most prevalent class, as identified by LCA, was a moderate-severe class (prevalence 46.5%), followed by a severe melancholic class (prevalence 38.4%), and a severe atypical class (prevalence 15.0%). The strongest distinguishing features between the three classes were appetite and weight and, to a lesser extent, psychomotor symptoms and loss of interest. Compared with the melancholic class, the severe atypical class had the highest prevalence of females, the lowest mean age, the highest BMI, and highest prevalence of both cardiovascular disease, and metabolic syndrome.
   Limitations: The strongest distinguishing symptoms, appetite and weight, could be correlated. Further, only longitudinal studies could demonstrate whether the identified classes are stable on the long term.
   Discussion: In older persons with depressive disorders, three distinct subtypes were identified, similar to subtypes found in younger adults. The strongest distinguishing features were appetite and weight; moreover, classes differed strongly on prevalence of metabolic syndrome and cardiovascular disease. These findings suggest differences in the involvement of metabolic pathways across classes, which should be considered when investigating the pathogenesis and (eventually) treatment of depression in older persons.
C1 [Veltman, E. M.; van der Mast, R. C.] Leiden Univ, Med Ctr, Dept Psychiat, Leiden, Netherlands.
   [Lamers, F.; Comijs, H. C.; Stek, M. L.; Rhebergen, D.] Vrije Univ Amsterdam, Med Ctr, GGZ inGeest, Dept Psychiat, Amsterdam, Netherlands.
   [Lamers, F.; Comijs, H. C.; Stek, M. L.; Rhebergen, D.] Vrije Univ Amsterdam, Med Ctr, EMGO Inst Hlth & Care Res, Amsterdam, Netherlands.
   [van der Mast, R. C.] Univ Antwerp, CAPRI, Dept Psychiat, Antwerp, Belgium.
   [de Waal, M. W. M.] Leiden Univ, Med Ctr, Dept Publ Hlth & Primary Care, Leiden, Netherlands.
C3 Leiden University - Excl LUMC; Leiden University; Leiden University
   Medical Center (LUMC); Vrije Universiteit Amsterdam; Vrije Universiteit
   Amsterdam; University of Antwerp; Leiden University; Leiden University
   Medical Center (LUMC); Leiden University - Excl LUMC
RP Veltman, EM (corresponding author), Leiden Univ, Med Ctr, Dept Psychiat, Leiden, Netherlands.
EM evelineveltman@gmail.com
RI De Waal, Margot/HHZ-5204-2022; Lamers, Femke/G-5161-2012
OI Lamers, Femke/0000-0003-4344-5766
FU European Union Seventh Framework Programme (FP7) [PCIG12-GA-2012-334065]
FX FL has received funding from the European Union Seventh Framework
   Programme (FP7/2007-2013) under grant agreement No.
   PCIG12-GA-2012-334065.
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NR 68
TC 42
Z9 43
U1 2
U2 30
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD AUG 15
PY 2017
VL 218
BP 123
EP 130
DI 10.1016/j.jad.2017.04.059
PG 8
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA EZ1TA
UT WOS:000404492500018
PM 28472702
DA 2025-06-11
ER

PT J
AU Garin, MCB
   Kalix, B
   Morabia, A
   James, RW
AF Garin, MCB
   Kalix, B
   Morabia, A
   James, RW
TI Small, dense lipoprotein particles and reduced paraoxonase-1 in patients
   with the metabolic syndrome
SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Article
ID CORONARY-ARTERY-DISEASE; 3RD NATIONAL-HEALTH; SERUM PARAOXONASE;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; HYPERINSULINEMIA; ATHEROSCLEROSIS;
   CHOLESTEROL; PREVALENCE; RISK
AB The presence of the metabolic syndrome ( World Health Organization definition) and its association with lipoprotein abnormalities suggestive of greater susceptibility to oxidative stress have been analyzed in patients with angiographically defined coronary artery disease. The odds ratio for the presence of the metabolic syndrome was significantly higher in coronary artery disease-positive patients (P < 0.001). The metabolic syndrome was also associated with more severe coronary disease (P < 0.01). Patients with the metabolic syndrome had significantly decreased low-density lipoprotein-cholesterol/apolipoprotein B and high-density lipoprotein-cholesterol/ apolipoprotein AI ratios, indicative of the presence of small, dense lipoprotein particles. The syndrome was also associated with reduced concentrations and activities of the antioxidant enzyme, paraoxonase-1. The metabolic syndrome is characterized by smaller, denser lipoprotein particles that increase their susceptibility to oxidative modifications and diminished serum paraoxonase-1, which is a major determinant of the antioxidant capacity of high-density lipoproteins. These may be contributory factors to the increased presence and severity of coronary disease in such patients.
C1 Univ Hosp, Dept Endocrinol Diabet & Nutr, Clin Diabet Unit, CH-1211 Geneva, Switzerland.
   Univ Hosp, Dept Clin Epidemiol, CH-1211 Geneva, Switzerland.
C3 University of Geneva; University of Geneva
RP Univ Hosp, Dept Endocrinol Diabet & Nutr, Clin Diabet Unit, CH-1211 Geneva, Switzerland.
EM richard.james@hcuge.ch
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NR 36
TC 56
Z9 60
U1 0
U2 0
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0021-972X
EI 1945-7197
J9 J CLIN ENDOCR METAB
JI J. Clin. Endocrinol. Metab.
PD APR
PY 2005
VL 90
IS 4
BP 2264
EP 2269
DI 10.1210/jc.2004-1295
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 914BG
UT WOS:000228198900055
PM 15687341
OA Bronze
DA 2025-06-11
ER

PT J
AU Kozakova, M
   Gastaldelli, A
   Morizzo, C
   Hojlund, K
   Nilssson, PM
   Ferrannini, E
   Palombo, C
AF Kozakova, Michaela
   Gastaldelli, Amalia
   Morizzo, Carmela
   Hojlund, Kurt
   Nilssson, Peter M.
   Ferrannini, Ele
   Palombo, Carlo
CA RISC Investigators
TI Gamma-glutamyltransferase, arterial remodeling and prehypertension in a
   healthy population at low cardiometabolic risk
SO JOURNAL OF HUMAN HYPERTENSION
LA English
DT Article
ID FATTY LIVER INDEX; OXIDATIVE STRESS; INSULIN-RESISTANCE; GLUTATHIONE
   DEPLETION; BLOOD-PRESSURE; HYPERTENSION; STIFFNESS; YOUNG; MARKER;
   ADULTS
AB Plasma gamma-glutamyltransferase (GGT) was suggested to reflect the level of systemic oxidative stress. Oxidative stress induces changes in arterial structure and function and contributes to the development of hypertension. Therefore, GGT may be associated with arterial remodeling and blood pressure (BP) increment, even in absence of disease. To test this hypothesis, we evaluated, in 825 healthy subjects at low cardiometabolic risk, the associations of plasma GGT with carotid artery intima-media thickness (IMT), luminal diameter and prehypertension; in 154 subjects was evaluated also the association with aortic stiffness (cfPWV). Associations were controlled for insulin sensitivity, C-reactive protein, and life-style habits. In the main population, BP was remeasured after 3 years. Carotid diameter and cfPWV, but not IMT, were directly and independently related to plasma GGT. Subjects with prehypertension (N = 330) had higher GGT as compared with subjects with normal BP (22 [14] vs 17 [11] IU/L; adjusted P = 0.001), and within prehypertensive subjects, those who developed hypertension during 3 years had higher GGT than those without incident hypertension (27 [16] vs 21 [14] IU/L; adjusted P < 0.05). Within subjects with arterial stiffness measurement, those with prehypertension (N = 79) had higher both GGT and arterial stiffness (25 [14] vs 16 [20] IU/L and 9.11 +/- 1.24 vs 7.90 +/- 0.94 m/s; adjusted P < 0.01 and <0.05). In the view of previous evidence linking plasma GGT concentration to the level of systemic oxidative stress, our findings suggest a role of oxidative stress in subclinical arterial damage and in prehypertension, even in healthy subjects free of cardiometabolic risk. Arterial organ damage may represent the link between GGT and hypertension.
C1 [Kozakova, Michaela; Ferrannini, Ele] Univ Pisa, Dept Clin & Expt Med, Via Savi 10, Pisa 56126, Italy.
   [Gastaldelli, Amalia] CNR, Inst Clin Physiol, Cardiometab Risk Unit, Via Giuseppe Moruzzi 1, Pisa 56124, Italy.
   [Morizzo, Carmela; Palombo, Carlo] Univ Pisa, Dept Surg Med Mol Pathol & Crit Care Med, Via Savi 10, Pisa 56126, Italy.
   [Hojlund, Kurt] Univ Southern Denmark, Odense Univ Hosp, Steno Diabet Ctr Odense, JB Winslows Vej 4, Odense 5000 C, Denmark.
   [Hojlund, Kurt] Univ Southern Denmark, Dept Clin Res, JB Winslows Vej 4, Odense 5000 C, Denmark.
   [Nilssson, Peter M.] Lund Univ, Skane Univ Hosp, Dept Clin Sci, Malmo, Sweden.
C3 University of Pisa; Consiglio Nazionale delle Ricerche (CNR); Istituto
   di Fisiologia Clinica (IFC-CNR); University of Pisa; University of
   Southern Denmark; Odense University Hospital; University of Southern
   Denmark; Lund University; Skane University Hospital
RP Palombo, C (corresponding author), Univ Pisa, Dept Surg Med Mol Pathol & Crit Care Med, Via Savi 10, Pisa 56126, Italy.
EM carlo.palombo@unipi.it
RI Palombo, Carlo/K-7315-2016; Ferrannini, Ele/B-8198-2013; Gastaldelli,
   Amalia/H-3319-2014; Anderwald, Christian Heinz/AAG-2271-2021
OI Ciociaro, Demetrio/0009-0001-4701-0586; Jotic,
   Aleksandra/0000-0002-7997-9076; Nilsson, Peter/0000-0002-5652-8459;
   Gastaldelli, Amalia/0000-0003-2594-1651; Hojlund,
   Kurt/0000-0002-0891-4224; Lalic, Katarina/0000-0002-8070-1899; Guidone,
   Caterina/0000-0002-0241-7083; Nijpels, Giel/0000-0002-3679-9710; Lalic,
   Nebojsa/0000-0002-8082-6560; Anderwald, Christian
   Heinz/0000-0001-7485-0815; Melander, Olle/0000-0002-2581-484X; Boorsma,
   Wiebe/0009-0004-8619-6661
FU EU [QLG1-CT-2001-01252]
FX The European Group for the Study of Insulin Resistance (EGIR) RISC study
   was partly supported by EU grant QLG1-CT-2001-01252.
CR Block G, 2008, NUTR J, V7, DOI 10.1186/1475-2891-7-35
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NR 35
TC 1
Z9 1
U1 0
U2 6
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0950-9240
EI 1476-5527
J9 J HUM HYPERTENS
JI J. Hum. Hypertens.
PD APR
PY 2021
VL 35
IS 4
BP 334
EP 342
DI 10.1038/s41371-020-0337-1
EA APR 2020
PG 9
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA RO7WF
UT WOS:000529565500001
PM 32350440
DA 2025-06-11
ER

PT J
AU Bonifácio, DB
   Caldas, APS
   Costa, MAD
   Rocha, DMUP
   Hermsdorff, HHM
   Bressan, J
AF Bonifacio, Dandara Baia
   Silva Caldas, Ana Paula
   de Campos Costa, Mirian Aparecida
   Usuda Prado Rocha, Daniela Mayumi
   Miranda Hermsdorff, Helen Hermana
   Bressan, Josefina
TI Acute effect of a beverage containing Brazil and cashew nuts on
   oxidative stress, lipemia, and blood pressure of women with
   cardiometabolic risk (Brazilian Nuts Study): a randomized clinical trial
SO APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
LA English
DT Article
DE cashew nut; Brazil nut; lipid peroxidation; cardiovascular diseases
ID NUTRITIONAL COMPOSITION; ANTIOXIDANT CAPACITY; CONSUMPTION; PLASMA;
   LIPIDS; INFLAMMATION; INHIBITION; MARKERS; IMPACT
AB Nuts are important sources of antioxidants that combat oxidative stress and improve lipid profile as well as vascular function. However, the intake of typical Brazilian nuts and its acute effect on cardiovascular health needs to be better understood. Thus, the present study aimed to evaluate the acute effect of a beverage containing cashew (Anacardium occidentale L.) and Brazil nuts (Bertholletia excelsa H.B.K.) on postprandial oxidative stress, lipemia, and blood pressure of adult women aged 20 to 55 years with cardiometabolic risk. This was an acute, randomized, parallel arm, controlled clinical trial. The participants received either a beverage containing nuts (30 g Brazil nuts + 15 g cashew nuts) or a beverage without nuts with similarmacronutrient composition. Oxidative stress markers and lipid profiles were evaluated at fasting and 4 h after beverage consumption. Blood pressure wasmeasured during fasting and after beverage intake (1, 2, 3, and 4 h). In the postprandial state, there was a greater reduction in malondialdehyde levels in the intervention group compared to the control group (-12.3 +/- 0.59 vs. -10.7 +/- 0.43 mu mol/mL; p < 0.05), which was positively correlated with the concentrations of TG (r = 0.399; p < 0.05), VLDL (r = 0.399; p < 0.05), TG/HDL (r = 0.380; p < 0.05), and blood pressure (iAUC SBP r = 0.391; p < 0.05, iAUC DBP r = 0.409; p < 0.05). The remaining oxidative stress markers showed similar postprandial changes between groups. In women with cardiometabolic risk, a beverage containing Brazilian nuts promoted a significant acute reduction on postprandial malondialdehyde levels.
C1 [Bonifacio, Dandara Baia; Silva Caldas, Ana Paula; Usuda Prado Rocha, Daniela Mayumi; Miranda Hermsdorff, Helen Hermana; Bressan, Josefina] Univ Fed Vicosa, Dept Nutr & Hlth, Vicosa, MG, Brazil.
   [de Campos Costa, Mirian Aparecida] Univ Fed Vicosa, Dept Food Sci & Technol, Vicosa, MG, Brazil.
C3 Universidade Federal de Vicosa; Universidade Federal de Vicosa
RP Bressan, J (corresponding author), Univ Fed Vicosa, Dept Nutr & Hlth, Vicosa, MG, Brazil.
EM jbrm@ufv.br
RI Caldas, Ana Paula/E-8411-2017; Bressan, Josefina/A-2598-2009; Bonifacio,
   Dandara/IKD-0539-2023; Rocha, Daniela Mayumi/B-4255-2018; Hermsdorff,
   Helen Hermana Miranda/H-4525-2015
OI Rocha, Daniela Mayumi/0000-0001-6130-0179; Silva Caldas, Ana
   Paula/0000-0002-7517-3323; Baia Bonifacio, Dandara/0000-0002-0618-5275;
   Hermsdorff, Helen Hermana Miranda/0000-0002-4441-6572; de Campos Costa,
   Mirian Aparecida/0000-0003-0532-5798
FU Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
   [001]; Fundacao de Amparo a Pesquisa do Estado de Minas Gerais (FAPEMIG)
   [CDS-APQ-00369-17]; Conselho Nacional de Desenvolvimento Cientifico e
   Tecnologico (CNPq) [428038/2018-2]
FX We thank all participants who kindly agreed to participate in this
   study. Additionally, we are grateful to Bioclin Global (R), Inovam
   Brasil (R) (Ji-Parana, Brazil), Amendoas do Brazil, Embrapa Agropecuaria
   Tropical (CE, Brazil), and the Federal University of Vicosa. This work
   was supported by the Coordenacao de Aperfeicoamento de Pessoal de Nivel
   Superior (CAPES) [Finance Code 001], Fundacao de Amparo a Pesquisa do
   Estado de Minas Gerais (FAPEMIG) [Process: CDS-APQ-00369-17], and the
   Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
   [Process 428038/2018-2].
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NR 47
TC 7
Z9 7
U1 0
U2 1
PU CANADIAN SCIENCE PUBLISHING
PI OTTAWA
PA 123 Slater Street, Suite 610, OTTAWA, ON K1P 5H2, CANADA
SN 1715-5312
EI 1715-5320
J9 APPL PHYSIOL NUTR ME
JI Appl. Physiol. Nutr. Metab.
PD OCT
PY 2023
VL 48
IS 10
BP 789
EP 798
DI 10.1139/apnm-2023-0049
EA AUG 2023
PG 10
WC Nutrition & Dietetics; Physiology; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics; Physiology; Sport Sciences
GA JS0M8
UT WOS:001052250500001
PM 37311253
DA 2025-06-11
ER

PT J
AU Park, YH
   Kim, W
   Park, JH
   Kim, HJ
AF Park, Young Hwan
   Kim, Woon
   Park, Ji Hyun
   Kim, Hak Jun
TI Impact of metabolic syndrome on patient outcomes of supination-external
   rotation ankle fracture
SO INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
LA English
DT Article
DE Diabetes; Hypertension; Obesity; Olerud-Molander ankle score; Visual
   analog scale; Kellgren and Lawrence scale
ID 3RD NATIONAL-HEALTH; OPERATIVE TREATMENT; PHYSICAL-ACTIVITY; RISK;
   REHABILITATION; OSTEOARTHRITIS; PARTICIPATION; DEPRESSION; OBESITY;
   ADULTS
AB Metabolic syndrome has been known as a risk factor for morbidity following orthopedic procedures, yet its impact on surgical treatment of ankle fractures remains unclear. The aim of this study was to compare the patient outcomes of surgical treatment of supination-external rotation ankle fractures in patients with and without metabolic syndrome. This study was designed as a retrospective matched case-control study. Forty-nine patients with supination-external rotation ankle fracture and metabolic syndrome were age-, sex-, and fracture type-matched with 49 controls without metabolic syndrome. Olerud-Molander Ankle Score (OMAS), Visual Analog Scale (VAS), Kellgren and Lawrence (K&L) scale, and complications were assessed at final follow-up. The mean postoperative follow-up was 19.5 months (range, 13- 44). The OMAS measurements in the metabolic syndrome group were lower than those in the control group (p = 0.006) and the VAS for pain measurements in the metabolic syndrome group were greater than those in the control group (p < 0.001). The K&L scale and complications did not differ significantly between the two groups. Patients with metabolic syndrome are at risk for higher pain scores and lower functional outcomes after surgical treatment for supination-external rotation ankle fracture. These results suggest that metabolic syndrome should be treated together with ankle fractures. (C) 2019 Elsevier Ltd. All rights reserved.
C1 [Park, Young Hwan; Kim, Woon; Park, Ji Hyun; Kim, Hak Jun] Korea Univ, Guro Hosp, Dept Orthopaed Surg, 148 Gurodong Ro, Seoul 08308, South Korea.
C3 Korea University; Korea University Medicine (KU Medicine)
RP Kim, HJ (corresponding author), Korea Univ, Guro Hosp, Dept Orthopaed Surg, 148 Gurodong Ro, Seoul 08308, South Korea.
EM ospark1982@gmail.com; dnscjswo@gmail.com; ziphun@hanmail.net;
   hjunkimos@gmail.com
RI kim, woon/AFU-0088-2022; Park, Ji/AAT-3233-2020; Kim, Hak/AAR-5929-2020
OI Kim, Hak Jun/0000-0003-3633-6174
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NR 32
TC 5
Z9 5
U1 0
U2 0
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0020-1383
EI 1879-0267
J9 INJURY
JI Injury-Int. J. Care Inj.
PD JUL
PY 2019
VL 50
IS 7
BP 1388
EP 1391
DI 10.1016/j.injury.2019.05.033
PG 4
WC Critical Care Medicine; Emergency Medicine; Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Emergency Medicine; Orthopedics; Surgery
GA IG3SO
UT WOS:000473725900022
PM 31176479
DA 2025-06-11
ER

PT J
AU Crist, BL
   Alekel, DL
   Ritland, LM
   Hanson, LN
   Genschel, U
   Reddy, MB
AF Crist, Betsy L.
   Alekel, D. Lee
   Ritland, Laura M.
   Hanson, Laura N.
   Genschel, Ulrike
   Reddy, Manju B.
TI Association of Oxidative Stress, Iron, and Centralized Fat Mass in
   Healthy Postmenopausal Women
SO JOURNAL OF WOMENS HEALTH
LA English
DT Article
ID CARDIOVASCULAR-DISEASE RISK; INSULIN-RESISTANCE SYNDROME;
   CORONARY-HEART-DISEASE; SERUM FERRITIN; MYOCARDIAL-INFARCTION; METABOLIC
   SYNDROME; OXIDANT STRESS; MEN; OBESITY; INFLAMMATION
AB Objective: Centralized adiposity, insulin resistance, excess iron, and elevated oxidative stress place postmenopausal women at risk for atherosclerotic cardiovascular disease (CVD). The objective of this study was to determine the relationship among excess iron, oxidative stress, and centralized fat mass in healthy postmenopausal women.
   Methods: The parent project recruited healthy women for a randomized, double-blind, clinical trial designed to examine the effect of soy isoflavones on bone. At baseline (n=122), we measured three antioxidant enzymes, iron status indices (serum ferritin among others), oxidative stress indices (oxidized low-density lipoprotein [oxLDL], urinary isoprostanes [PGF(2 alpha)], protein carbonyls, DNA damage), and waist, hip, and thigh fat mass using dual-energy x-ray absorptiometry (DXA). We calculated insulin resistance using the homeostasis model assessment (HOMA). Multiple regression analysis was used to determine the CVD risk factors that contributed to oxidative stress and centralized fat mass (waist+hip=thigh AndGynFM ratio).
   Results: Almost 14% (p<0.0005) of the variability in oxLDL was accounted for by AndGynFM ratio (6.1%, p<0.0005), age (4.0%, p=0.012), and serum iron (2.8%, p=0.053). Similarly, 16% (p<0.0001) of the variability in PGF2a was accounted for by the AndGynFM ratio (4.8%, p=0.011), HOMA (3.9%, p=0.021), and serum iron (2.7%, p=0.054). We accounted for 33% (p <= 0.0001) of the variability in AndGynFM ratio by high-density lipoprotein cholesterol (HDL-C) (4.3%, p=0.008), ferritin (4.9%, p=0.005), HOMA (4.5%, p=0.006), oxLDL (2.6%, p=0.04), and PGF(2 alpha) (3.0%, p=0.025).
   Conclusions: Our study suggests that reducing centralized fat mass and maintaining a favorable lipid profile, antioxidant status, and iron status all may be important in protecting postmenopausal women from atherosclerotic CVD.
C1 [Crist, Betsy L.; Alekel, D. Lee; Ritland, Laura M.; Hanson, Laura N.; Reddy, Manju B.] Iowa State Univ, Dept Food Sci & Human Nutr, Ames, IA 50011 USA.
   [Alekel, D. Lee] Iowa State Univ, Nutr & Wellness Res Ctr, Ames, IA 50011 USA.
   [Genschel, Ulrike] Iowa State Univ, Dept Stat, Ames, IA 50011 USA.
C3 Iowa State University; Iowa State University; Iowa State University
RP Reddy, MB (corresponding author), Iowa State Univ, Dept Food Sci & Human Nutr, 1127 HNSB, Ames, IA 50011 USA.
EM mbreddy@iastate.edu
RI Genschel, Ulrike/JXN-5167-2024
OI Genschel, Ulrike/0000-0001-8488-2327
FU American Heart Association (AHA-Heartland Affiliate) [0350550Z];
   National Institute of Arthritis and Musculoskeletal and Skin Diseases
   (NIAMS) [RO1 AR046922 A2]; National Institute of Environmental Health
   Sciences (NIEHS) [P01 ES012020]; Office of Dietary Supplements (ODS);
   National Center of Complementary and Alternative Medicine (NCCAM)
   [95P50AT004155]; ODS; National Institutes of Health; American Heart
   Association (AHA) [0350550Z] Funding Source: American Heart Association
   (AHA)
FX The project described was supported by a grant from the American Heart
   Association (AHA-Heartland Affiliate, 0350550Z), by a grant (RO1
   AR046922 A2) from the National Institute of Arthritis and
   Musculoskeletal and Skin Diseases (NIAMS), by a grant (P01 ES012020)
   from the National Institute of Environmental Health Sciences (NIEHS) and
   the Office of Dietary Supplements (ODS), and by a grant (95P50AT004155)
   from the National Center of Complementary and Alternative Medicine
   (NCCAM) and ODS, the National Institutes of Health. There are no
   conflicts of interest.
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NR 40
TC 36
Z9 40
U1 0
U2 3
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-9996
EI 1931-843X
J9 J WOMENS HEALTH
JI J. Womens Health
PD JUN
PY 2009
VL 18
IS 6
BP 795
EP 801
DI 10.1089/jwh.2008.0988
PG 7
WC Public, Environmental & Occupational Health; Medicine, General &
   Internal; Obstetrics & Gynecology; Women's Studies
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; General & Internal
   Medicine; Obstetrics & Gynecology; Women's Studies
GA 457BW
UT WOS:000266901200005
PM 19456248
OA Green Published, Green Accepted, Green Submitted
DA 2025-06-11
ER

PT J
AU Wu, QL
   Huang, HY
   Wang, XJ
   Tao, XL
AF Wu, Qunli
   Huang, Haiyan
   Wang, Xiaojun
   Tao, Xiaoling
TI The Correlation between Depression during Pregnancy and Metabolic
   Syndrome
SO ACTAS ESPANOLAS DE PSIQUIATRIA
LA English
DT Article
DE metabolic syndrome; depression during pregnancy; preg- nancy;
   correlation
AB Background: In recent years, the incidence of depression during pregnancy has gradually increased, and the disorder of lipid metabolism in patients with depression is an important research direction. Therefore, this study aimed to explore the correlation between depression during pregnancy and metabolic syndrome (MS). Methods: A total of 113 pregnant women diagnosed as depression during pregnancy from November 2019 to January 2022 were selected as the observation group. After excluding 3 cases, 110 cases were finally included. And 102 pregnant women who were not diagnosed as depression during pregnancy in the same period were selected as the control group. After excluding 2 cases, 100 cases were finally included for comparative study. The levels of various parameters, including serum triglyceride (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C), fasting plasma glucose (FPG), C-reactive protein (CRP), systolic blood pressure (SBP), and diastolic blood pressure (DBP) were compared between the two groups. Furthermore, the Edinburgh Postnatal Depression Scale (EPDS) was used to evaluate the depression scores of postpartum women. Additionally, the correlation between EPDS scores and clinical indexes was assessed in patients with depression during pregnancy. Results: We observed that the body weight, EPDS score, the proportion of hyperglycemia, hypertension, and dyslipidemia were significantly higher in the observation group compared to the control group (p < 0.001). Further- more, the observation group exhibited significantly higher levels of TG, TC, HDL-C, LDL-C, FPG, CRP, SBP, and DBP than the control group (p < 0.001). Pearson linear correlation analysis revealed that TG, TC, HDL-C, LDL-C, FPG, CRP, SBP, and DBP levels were positively correlated with EPDS scores (p < 0.001). Conclusion: This study indicates a specific correlation between MS and depression during pregnancy, and MS-related indicators are positively correlated with EPDS scores among these individuals.
C1 [Wu, Qunli; Huang, Haiyan; Wang, Xiaojun; Tao, Xiaoling] Wenzhou Med Univ, Dept Obstet & Gynecol, Taizhou Hosp Zhejiang Prov, Taizhou 318000, Zhejiang, Peoples R China.
C3 Wenzhou Medical University
RP Tao, XL (corresponding author), Wenzhou Med Univ, Dept Obstet & Gynecol, Taizhou Hosp Zhejiang Prov, Taizhou 318000, Zhejiang, Peoples R China.
EM Jane816102@163.com
FU Enze Medical Center (Group) Scientific Research Fund [20EZC34]
FX This research was funded by Enze Medical Center (Group) Scientific
   Research Fund, grant No. 20EZC34.
CR Barat S, 2024, INT J FERTIL STERIL, V18, P271, DOI 10.22074/ijfs.2023.1983056.1412
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NR 23
TC 0
Z9 0
U1 2
U2 3
PU JUAN JOSE LOPEZ-IBOR FOUNDATION
PI MADRID
PA NO 2, MADRID, 28035, SPAIN
SN 1139-9287
EI 1578-2735
J9 ACTAS ESP PSIQUIATRI
JI Actas Esp. Psiquiatri.
PD JUL-AUG
PY 2024
VL 52
IS 4
BP 519
EP 525
DI 10.62641/aep.v52i4.1700
PG 7
WC Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Psychiatry
GA C2I9U
UT WOS:001287656500016
PM 39129684
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Perez-Cornago, A
   Zulet, MA
   Martinez, JA
AF Perez-Cornago, Aurora
   Zulet, M. Angeles
   Martinez, J. Alfredo
TI Association between mood and diet quality in subjects with metabolic
   syndrome participating in a behavioural weight-loss programme: A
   cross-sectional assessment
SO NUTRITIONAL NEUROSCIENCE
LA English
DT Article
DE Mood; Nutrients; Diet; Metabolic syndrome; Mental disorders
ID DEPRESSIVE SYMPTOMS; CARDIOVASCULAR-DISEASE; METAANALYSIS; PATTERN;
   ANXIETY; STRESS; PREVALENCE; GUIDELINES; HABITS
AB Background/objective: The interplay between individual's mood fluctuations and nutrition has important health implications. However, little information is available on the relationship between dietary intake and mood state in a population with metabolic syndrome (MetS). The aim of the present study was to evaluate the association between dietary intake and mood state in subjects with MetS.
   Methods: This cross-sectional study was based on the baseline data of 84 volunteers (mean age 49 +/- 1 years) recruited into the Metabolic Syndrome Reduction in Navarra-Spain (RESMENA-S) study. Mood state was determined using a mood thermometer visual analogue scale. The dietary intake was assessed with a 48-hours weighted food record, from which a Healthy Eating Index (HEI) score was obtained. Anthropometrical measurements and biochemical parameters were also analysed.
   Results: At baseline, a positive association between mood thermometer and HEI was observed. Among the 10 HEI components, vegetables, fruits, calories from lipids, saturated fatty acids, and dietary variety were related with higher mood. Moreover, those participants who consumed more water, fibre, vitamin B6, ascorbic acid, tryptophan, magnesium, and selenium have higher mood.
   Discussion: In conclusion, an association between both the overall dietary pattern and isolated nutrients with mood state was observed. The analyses of both dietary patterns and specific nutrients are important to determine the association between mental disorders and dietary intake.
C1 [Perez-Cornago, Aurora; Zulet, M. Angeles; Martinez, J. Alfredo] Univ Navarra, Dept Nutr Food Sci & Physiol, Pamplona 31008, Spain.
   [Zulet, M. Angeles; Martinez, J. Alfredo] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr CIBERobn, Madrid, Spain.
C3 University of Navarra; Instituto de Salud Carlos III; CIBER - Centro de
   Investigacion Biomedica en Red; CIBEROBN
RP Martinez, JA (corresponding author), Univ Navarra, Dept Nutr Food Sci & Physiol, C Irunlarrea 1, Pamplona 31008, Spain.
EM jalfmtz@unav.es
RI Zulet, M./H-1317-2017; Perez-Cornago, Aurora/C-1097-2016; Martinez
   Hernandez, J Alfredo/K-8709-2014
OI Perez-Cornago, Aurora/0000-0002-5652-356X; Martinez Hernandez, J
   Alfredo/0000-0001-5218-6941
FU Health Department of the Government of Navarra [48/2009]; Linea Especial
   about Nutrition; Obesity and Health (University of Navarra) [LE/97];
   CIBERobn; RETICS; Asociacion de Amigos Universidad de Navarra
FX The present work was supported by the Health Department of the
   Government of Navarra (48/2009) and the Linea Especial about Nutrition,
   Obesity and Health (University of Navarra LE/97). The support from
   CIBERobn and RETICS schemes is gratefully accredited. The pre-doctoral
   research grant to Aurora Perez-Cornago from the Asociacion de Amigos
   Universidad de Navarra is also gratefully acknowledged.
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NR 42
TC 12
Z9 14
U1 2
U2 18
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1028-415X
EI 1476-8305
J9 NUTR NEUROSCI
JI Nutr. Neurosci.
PD APR
PY 2015
VL 18
IS 3
BP 137
EP 144
DI 10.1179/1476830514Y.0000000116
PG 8
WC Neurosciences; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Nutrition & Dietetics
GA CD5IU
UT WOS:000351122000006
PM 24627977
DA 2025-06-11
ER

PT J
AU El-Fawal, R
   El Fayoumi, HM
   Mahmoud, MF
AF El-Fawal, Rania
   El Fayoumi, Hassan M.
   Mahmoud, Mona F.
TI Diosmin and crocin alleviate nephropathy in metabolic syndrome rat
   model: Effect on oxidative stress and low grade inflammation
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Article
DE Metabolic syndrome; Nephropathy; Diosmin; Crocin
ID ENDOTHELIAL-DEPENDENT RELAXATION; TUMOR-NECROSIS-FACTOR;
   DIABETIC-NEPHROPATHY; HYPERTENSIVE-RATS; DOWN-REGULATION;
   KIDNEY-DISEASE; NO PRODUCTION; SATIVUS L.; TNF-ALPHA;
   ISCHEMIA/REPERFUSION
AB Nephropathy is a serious complication of metabolic syndrome (MS), a global epidemic disorder. This study was undertaken to investigate the actions of diosmin and crocin, two natural ingredients, on diabetic nephropathy in a rat model of MS and the underlying mechanism(s). Metabolic syndrome was induced by the addition of 10% fructose to drinking water and placing the rats on high-salt diet for 16 weeks. Diosmin and Crocin were orally administrated daily for 10 weeks starting at week 6. At the end of study, arterial blood pressure was non-invasively recorded. Urine, serum and kidneys were collected for renal function, oxidative stress, glycemic parameters, inflammatory markers and histological analysis. Both Diosmin and Crocin improved insulin resistance, decreased blood pressure, uric acid, lipoproteins and blocked diabetic nephropathy as indicated by reduction of albumin excretion rate and albumin/creatinine ratio. They alleviated the impaired filtration in MS as indicated by increased creatinine clearance. They also ameliorated oxidative stress and the low-grade 1-inflammation as indicated by reduction of serum TNF-alpha and inflammatory cells. These observations suggest that both Diosmin and Crocin alleviate metabolic syndrome and the associated nephropathy in rats, possibly, through inhibiting oxidative stress and inflammation.
C1 [El-Fawal, Rania; El Fayoumi, Hassan M.; Mahmoud, Mona F.] Zagazig Univ, Fac Pharm, Dept Pharmacol & Toxicol, Zagazig 44519, Egypt.
   [El Fayoumi, Hassan M.] Sinai Univ Qantara, Fac Pharm, El Arish El Masaid, Egypt.
C3 Egyptian Knowledge Bank (EKB); Zagazig University; Egyptian Knowledge
   Bank (EKB); Sinai University
RP Mahmoud, MF (corresponding author), Zagazig Univ, Fac Pharm, Dept Pharmacol, Zagazig 44519, Egypt.
EM mfabdelaziz@zu.edu.eg
RI Mahmoud, Mona/Q-8851-2019
OI Mahmoud, Mona/0000-0002-5312-2066
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NR 58
TC 25
Z9 25
U1 0
U2 17
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD JUN
PY 2018
VL 102
BP 930
EP 937
DI 10.1016/j.biopha.2018.03.162
PG 8
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA GG3HV
UT WOS:000432583800106
PM 29710548
DA 2025-06-11
ER

PT J
AU Butkowski, EG
   Al-Aubaidy, HA
   Jelinek, HF
AF Butkowski, E. G.
   Al-Aubaidy, H. A.
   Jelinek, H. F.
TI Interaction of homocysteine, glutathione and 8-hydroxy-2′-deoxyguanosine
   in metabolic syndrome progression
SO CLINICAL BIOCHEMISTRY
LA English
DT Article
DE Homocysteine; 8-OHdG; Glutathione; Metabolic syndrome; Oxidative stress
ID OXIDATIVE STRESS; SUBCLINICAL ATHEROSCLEROSIS; INSULIN-RESISTANCE;
   DIABETES-MELLITUS; TERM TREATMENT; INFLAMMATION; PLASMA; FOLATE; RISK;
   VITAMIN-B12
AB Purpose: The role of homocysteine (Hcy) and associated oxidative stress processes in the metabolic syndrome (MetS) continuum has not been explored extensively. Changes in Hcy and associated oxidative stress in relation to the number of metabolic syndrome factors present are explored in this study.
   Method: Participants (n = 266) attending a rural diabetes screening clinic had their medical history recorded as well as body mass index, Hcy, glucose, cholesterol, glutathione (GSH), and 8-hydroxy-2-deoxyguanosine (8-OHdG) measured.
   Result: A significant elevation in Hcy (9.5 mu mol/mu L +/- 2 vs. 10.6 mu mol/L +/- 3, p = 0.03) and 8-OHdG (307 pg/mL +/- 516 vs. 1130 pg/mL +/- 1155, p = 0.0001) was observed between the noMetS and MetS groups. Hcy increased with the addition of MetS factors paralleled by 8-OHdG and GSH. A dramatic increase was seen in 8-OHdG, nearly doubling between 2 MetS and 3 MetS factors present (p = 0.0001).
   Conclusion: Homocysteine may be a useful marker together with 8-OHdG in assessing the extent of metabolic syndrome in a rural population. Crown Copyright (C) 2016 Published by Elsevier Inc. on behalf of The Canadian Society of Clinical Chemists. All rights reserved.
C1 [Butkowski, E. G.; Jelinek, H. F.] Charles Sturt Univ, Sch Community Hlth, Albury, NSW, Australia.
   [Al-Aubaidy, H. A.] Univ Tasmania, Sch Med, Hobart, Tas, Australia.
   [Jelinek, H. F.] Macquarie Univ, Australian Sch Adv Med, Sydney, NSW, Australia.
C3 Charles Sturt University; University of Tasmania; Macquarie University
RP Jelinek, HF (corresponding author), Charles Sturt Univ, Sch Community Hlth, Albury, NSW, Australia.
EM hjelinek@csu.edu.au
RI Jelinek, Herbert/S-6779-2019; Al-Aubaidy, Hayder/J-7563-2014
OI Jelinek, Herbert F/0000-0001-5457-6193
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NR 42
TC 13
Z9 13
U1 0
U2 10
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0009-9120
EI 1873-2933
J9 CLIN BIOCHEM
JI Clin. Biochem.
PD FEB
PY 2017
VL 50
IS 3
BP 116
EP 120
DI 10.1016/j.clinbiochem.2016.10.006
PG 5
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA EK2CW
UT WOS:000393736100004
PM 27751791
DA 2025-06-11
ER

PT J
AU Benarroch, EE
AF Benarroch, EE
TI Paraventricular nucleus, stress response, and cardiovascular disease
SO CLINICAL AUTONOMIC RESEARCH
LA English
DT Review
DE hypothalamus; hypertension; heart failure; metabolic syndrome
ID ROSTRAL VENTROLATERAL MEDULLA; SYMPATHETIC-NERVE ACTIVITY;
   PITUITARY-ADRENAL AXIS; BRAIN ANGIOTENSIN-II; SPINAL-CORD; NITRIC-OXIDE;
   MAGNOCELLULAR NEURONS; METABOLIC SYNDROME; BLOOD-PRESSURE; HEART-FAILURE
AB The paraventricular nucleus of the hypothalamus (PVN) is a complex effector structure that initiates endocrine and autonomic responses to stress. It receives inputs from visceral receptors, circulating hormones such as angiotensin II, and limbic circuits and contains neurons that release vasopressin, activate the adrenocortical axis, and activate preganglionic sympathetic or parasympathetic outflows. The neurochemical control of the different subgroups of PVN neurons is complex. The PVN has been implicated in the pathophysiology of congestive heart failure and the metabolic syndrome.
C1 Mayo Clin, Dept Neurol, Rochester, MN 55905 USA.
C3 Mayo Clinic
RP Mayo Clin, Dept Neurol, 811 Guggenheim Bldg,200 1st St W, Rochester, MN 55905 USA.
EM benarroch.eduardo@mayo.edu
FU NINDS NIH HHS [NS32352-P2] Funding Source: Medline
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NR 85
TC 128
Z9 151
U1 0
U2 19
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0959-9851
EI 1619-1560
J9 CLIN AUTON RES
JI Clin. Auton. Res.
PD AUG
PY 2005
VL 15
IS 4
BP 254
EP 263
DI 10.1007/s10286-005-0290-7
PG 10
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 954RX
UT WOS:000231173600007
PM 16032381
DA 2025-06-11
ER

PT J
AU Li, YC
   Liu, YM
   Shen, JD
   Chen, JJ
   Pei, YY
   Fang, XY
AF Li, Yu-Cheng
   Liu, Ya-Min
   Shen, Ji-Duo
   Chen, Jun-Jie
   Pei, Yang-Yi
   Fang, Xiao-Yan
TI Resveratrol Ameliorates the Depressive-Like Behaviors and Metabolic
   Abnormalities Induced by Chronic Corticosterone Injection
SO MOLECULES
LA English
DT Article
DE resveratrol; corticosterone; depression; metabolic abnormalities
ID UNPREDICTABLE MILD STRESS; MOUSE MODEL; GLUCOCORTICOID-RECEPTORS; MICE;
   ANTIDEPRESSANT; ANXIETY; POPULATION; RISK; RATS
AB Chronic glucocorticoid exposure is known to cause depression and metabolic disorders. It is critical to improve abnormal metabolic status as well as depressive-like behaviors in patients with long-term glucocorticoid therapy. This study aimed to investigate the effects of resveratrol on the depressive-like behaviors and metabolic abnormalities induced by chronic corticosterone injection. Male ICR mice were administrated corticosterone (40 mg/kg) by subcutaneous injection for three weeks. Resveratrol (50 and 100 mg/kg), fluoxetine (20 mg/kg) and pioglitazone (10 mg/kg) were given by oral gavage 30 min prior to corticosterone administration. The behavioral tests showed that resveratrol significantly reversed the depressive-like behaviors induced by corticosterone, including the reduced sucrose preference and increased immobility time in the forced swimming test. Moreover, resveratrol also increased the secretion of insulin, reduced serum level of glucose and improved blood lipid profiles in corticosterone-treated mice without affecting normal mice. However, fluoxetine only reverse depressive-like behaviors, and pioglitazone only prevent the dyslipidemia induced by corticosterone. Furthermore, resveratrol and pioglitazone decreased serum level of glucagon and corticosterone. The present results indicated that resveratrol can ameliorate depressive-like behaviors and metabolic abnormalities induced by corticosterone, which suggested that the multiple effects of resveratrol could be beneficial for patients with depression and/or metabolic syndrome associated with long-term glucocorticoid therapy.
C1 [Li, Yu-Cheng; Liu, Ya-Min; Shen, Ji-Duo; Chen, Jun-Jie; Pei, Yang-Yi; Fang, Xiao-Yan] Henan Univ Tradit Chinese Med, Coll Pharm, Zhengzhou 450046, Peoples R China.
C3 Henan University of Traditional Chinese Medicine
RP Li, YC; Fang, XY (corresponding author), Henan Univ Tradit Chinese Med, Coll Pharm, Zhengzhou 450046, Peoples R China.
EM Liyucheng@hactcm.edu.cn; yamin62261@163.com; lycdd1219@163.com;
   junjie102493@163.com; 18203977548@163.com; Fxylele@yeah.net
RI Chen, Junjie/AAF-8762-2019; Liu, Yamin/E-3353-2019
OI Li, Yu cheng/0000-0003-4611-8314
FU National Natural Science Foundation of China [81303278, 81673629];
   Provincial Scientific Research Special Foundation of Henan University of
   Traditional Chinese Medicine [2014KYYWF-QN19]; Talent Project of Science
   and Technology Innovation of Henan University of Traditional Chinese
   Medicine [2015XCXRC03]
FX This work was supported by grants from the National Natural Science
   Foundation of China (No. 81303278, 81673629), the Provincial Scientific
   Research Special Foundation of Henan University of Traditional Chinese
   Medicine (2014KYYWF-QN19), and the Talent Project of Science and
   Technology Innovation of Henan University of Traditional Chinese
   Medicine (2015XCXRC03).
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NR 40
TC 42
Z9 43
U1 1
U2 13
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1420-3049
J9 MOLECULES
JI Molecules
PD OCT
PY 2016
VL 21
IS 10
AR 1341
DI 10.3390/molecules21101341
PG 12
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA EE9AL
UT WOS:000389917900078
PM 27754387
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Sugai, T
   Suzuki, Y
   Yamazaki, M
   Shimoda, K
   Mori, T
   Ozeki, Y
   Matsuda, H
   Sugawara, N
   Yasui-Furukori, N
   Minami, Y
   Okamoto, K
   Sagae, T
   Someya, T
AF Sugai, Takuro
   Suzuki, Yutaro
   Yamazaki, Manabu
   Shimoda, Kazutaka
   Mori, Takao
   Ozeki, Yuji
   Matsuda, Hiroshi
   Sugawara, Norio
   Yasui-Furukori, Norio
   Minami, Yoshitake
   Okamoto, Kurefu
   Sagae, Toyoaki
   Someya, Toshiyuki
TI Difference in prevalence of metabolic syndrome between Japanese
   outpatients and inpatients with schizophrenia: A nationwide survey
SO SCHIZOPHRENIA RESEARCH
LA English
DT Article
DE Metabolic syndrome; Japanese mental health care system; Prevalence; The
   adapted adult treatment panel III (ATP III-A) criteria; The Japan
   Society for the Study of Obesity (JASSO) definition; Hospitalisation
ID SCHIZOAFFECTIVE DISORDER; MORTALITY
AB Patients with schizophrenia have a higher risk of metabolic syndrome (MetS). MetS prevalence varies with ethnicity. Although environmental factors, such as lack of physical activity and unbalanced diet, can lead to MetS, these may differ between outpatients and inpatients with schizophrenia. The Japanese mental health care system differs from that in other countries. However, few studies have investigated the prevalence of MetS in Japanese patients with schizophrenia. Therefore, we conducted a nationwide survey to clarify the prevalence of MetS in Japanese outpatients and inpatients with schizophrenia.
   We investigated the risk of MetS by questionnaire in 520 facilities for outpatients and 247 facilities for inpatients. There were 7655 outpatients and 15,461 inpatients with schizophrenia. MetS prevalence was based on the National Cholesterol Education Program Adult Treatment Panel III (ATP III-A) and the Japan Society for the Study of Obesity (JASSO).
   The overall MetS prevalence in outpatients using the ATP III-A definition was 34.2%, with 37.8% in men and 29.4% in women, compared with 13.0% in inpatients, with 12.3% in men and 13.9% in women. MetS prevalence in outpatients was approximately 2- to 3-fold higher than in inpatients.
   In conclusion, MetS prevalence in Japanese outpatients was approximately 3-fold higher than in inpatients. Therefore, we should pay more attention to the risk of physical disease in Japanese patients with schizophrenia, considering the difference in health characteristics between outpatients and inpatients. (C) 2016 Elsevier B.V. All rights reserved.
C1 [Sugai, Takuro; Suzuki, Yutaro; Someya, Toshiyuki] Niigata Univ, Grad Sch Med & Dent Sci, Dept Psychiat, Niigata 9518510, Japan.
   [Sugai, Takuro; Suzuki, Yutaro; Shimoda, Kazutaka; Ozeki, Yuji; Sugawara, Norio; Yasui-Furukori, Norio; Someya, Toshiyuki] Japanese Soc Clin Neuropsychopharmacol, Tokyo, Japan.
   [Yamazaki, Manabu; Mori, Takao; Matsuda, Hiroshi; Minami, Yoshitake; Okamoto, Kurefu] Japan Psychiat Hosp Assoc, Tokyo, Japan.
   [Shimoda, Kazutaka; Ozeki, Yuji] Dokkyo Med Univ, Sch Med, Dept Psychiat, Mibu, Tochigi, Japan.
   [Sugawara, Norio; Yasui-Furukori, Norio] Hirosaki Univ, Sch Med, Dept Neuropsychiat, Hirosaki, Aomori 036, Japan.
   [Sagae, Toyoaki] Yamagata Prefectural Yonezawa Univ Nutr Sci, Fac Hlth & Nutr, Dept Hlth & Nutr, Yonezawa, Yamagata, Japan.
C3 Niigata University; Dokkyo Medical University; Hirosaki University
RP Someya, T (corresponding author), Niigata Univ, Grad Sch Med & Dent Sci, Dept Psychiat, Chuo Ku, 1-757 Asahimachi Dori, Niigata 9518510, Japan.
EM psy@med.niigata-u.ac.jp
RI Someya, Toshiyuki/ABD-1878-2021
FU Eisai Co. Ltd.; Yoshitomi Pharmaceutical Industries; Dainippon Sumitomo
   Pharma Co. Ltd.; Astellas Pharma Inc.; Meiji Seika Pharma Co. Ltd.; Eli
   Lilly Japan, K.K.; Otsuka Pharmaceutical Co. Ltd.; GlaxoSmithKline K.K.;
   Janssen Pharmaceutical K.K.; MSD K.K.; Shionogi Co. Ltd.; Asahi Kasei
   Pharma Corp.; Novartis Pharma Co. Ltd.; Takeda Pharmaceutical Co. Ltd.;
   Ono Pharmaceutical Co. Ltd.; Tsumura Co.; Grants-in-Aid for Scientific
   Research [26461763, 25461740] Funding Source: KAKEN
FX This work was partially supported by Eisai Co. Ltd., Yoshitomi
   Pharmaceutical Industries, Dainippon Sumitomo Pharma Co. Ltd., Astellas
   Pharma Inc., Meiji Seika Pharma Co. Ltd., Eli Lilly Japan, K.K., Otsuka
   Pharmaceutical Co. Ltd., GlaxoSmithKline K.K., Janssen Pharmaceutical
   K.K., MSD K.K., Shionogi & Co. Ltd., Asahi Kasei Pharma Corp., Novartis
   Pharma Co. Ltd., Takeda Pharmaceutical Co. Ltd., Ono Pharmaceutical Co.
   Ltd., and Tsumura & Co. The funders had no role in study design, data
   collection and analysis, decision to publish, or preparation of the
   manuscript.
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NR 31
TC 19
Z9 20
U1 0
U2 9
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0920-9964
EI 1573-2509
J9 SCHIZOPHR RES
JI Schizophr. Res.
PD MAR
PY 2016
VL 171
IS 1-3
BP 68
EP 73
DI 10.1016/j.schres.2016.01.016
PG 6
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA DE1GS
UT WOS:000370375700009
PM 26811231
DA 2025-06-11
ER

PT J
AU Karadag, H
   Oner, O
   Karaoglan, A
   Orsel, S
   Demir, AU
   Firat, H
   Karadeniz, D
   Aksu, M
   Ardic, S
   Ucar, ZZ
   Sevim, S
   Yilmaz, H
   Itil, O
AF Karadag, Hasan
   Oner, Ozgur
   Karaoglan, Akfer
   Orsel, Sibel
   Demir, Ahmet Ugur
   Firat, Hikmet
   Karadeniz, Derya
   Aksu, Murat
   Ardic, Sadik
   Ucar, Zeynep Zeren
   Sevim, Serhan
   Yilmaz, Hikmet
   Itil, Oya
TI Body Mass Index and Sexual Dysfunction in Males and Females in a
   Population Study
SO KLINIK PSIKOFARMAKOLOJI BULTENI-BULLETIN OF CLINICAL PSYCHOPHARMACOLOGY
LA English
DT Article
DE sexual dysfunction; obesity; depression; anxiety
ID QUALITY-OF-LIFE; ERECTILE DYSFUNCTION; RISK-FACTORS; METABOLIC SYNDROME;
   OBESITY; PREVALENCE; OVERWEIGHT; WOMEN
AB The association of obesity with sexual dysfunctions is complex and far from clear. Most former studies consisted of small samples and did not control several possible confounding factors.
   Our aim was to investigate the association of BMI with current sexual dysfunction in males and females in a nationally representative population sample after controlling for age, the presence of cardiovascular disorders, diabetes, hypertension, thyroid diseases, anxiety and depression and also menopause in women. The sample included a total of 4162 subjects (2081 females and 2081males). The most frequent sexual problem was premature ejaculation (8.8%) in males and hypoactive sexual desire disorder (13.9%) in females. Univariate analysis showed that hypoactive sexual desire and erectile dysfunction in males and hypoactive sexual desire, lack of pleasure from sexuality and sexual pain in females were associated with obesity. Multivariate analysis indicated that age was significantly associated with almost all types of sexual problems in both sexes. The risks of having no active sexual life, hypoactive sexual desire, lack of pleasure from sexuality and erectile dysfunction were higher in males with diabetes mellitus. Depression and anxiety were associated with all types of sexual problems in females and with no active sexual life, hypoactive sexual desire, erectile dysfunction and premature ejaculation in men. In both sexes BMI was not associated with sexual problems after the confounding factors were controlled. The association of obesity with sexual dysfunction might be mediated by other factors.
C1 [Karadag, Hasan; Orsel, Sibel] Diskapi Yildirim Beyazit Training & Res Hosp, Dept Psychiat, Ankara, Turkey.
   [Oner, Ozgur] Ankara Univ, Sch Med, Dept Child & Adolescent Psychiat, TR-06100 Ankara, Turkey.
   [Karaoglan, Akfer] WHO, Ankara, Turkey.
   [Demir, Ahmet Ugur] Hacettepe Univ, Fac Med, Dept Chest Dis, TR-06100 Ankara, Turkey.
   [Firat, Hikmet; Ardic, Sadik] Diskapi Yildirim Beyazit Training & Res Hosp, Dept Chest Dis, Ankara, Turkey.
   [Karadeniz, Derya] Istanbul Univ, Cerrahpasa Fac Med, Dept Neurol, Istanbul, Turkey.
   [Aksu, Murat] Erciyes Univ, Dept Neurol, Kayseri, Turkey.
   [Ucar, Zeynep Zeren] Izmir Dr Suat Seren Training & Res Hosp, Dept Chest Dis, Izmir, Turkey.
   [Sevim, Serhan] Mersin Univ, Dept Neurol, Mersin, Turkey.
   [Yilmaz, Hikmet] Celal Bayar Univ, Fac Med, Dept Neurol, Manisa, Turkey.
   [Itil, Oya] Dokuz Eylul Univ, Sch Med, Dept Neurol, Izmir, Turkey.
C3 Diskapi Yildirim Beyazit Training & Research Hospital; Ankara
   University; World Health Organization; WHO Turkey; Hacettepe University;
   Diskapi Yildirim Beyazit Training & Research Hospital; Istanbul
   University; Istanbul University - Cerrahpasa; Erciyes University; Izmir
   Dr Suat Seren Chest Diseases & Thoracic Surgery Training & Research
   Hospital; Mersin University; Celal Bayar University; Dokuz Eylul
   University
RP Oner, O (corresponding author), Ankara Univ, Sch Med, Dept Child & Adolescent Psychiat, TR-06100 Ankara, Turkey.
EM ozgur.oner@yahoo.com
RI Orsel, Sibel/U-9276-2019; Sevim, Serhan/KBA-7417-2024; Karadeniz,
   Derya/ABA-6301-2020; Aksu, Murat/LHH-2544-2024; demir,
   ahmet/I-1957-2014; Karadag, Hasan/AAM-3991-2021; Karaoglan
   Kahilogullari, Akfer/F-2289-2014; FIRAT, Hikmet/E-3047-2017
OI FIRAT, Hikmet/0000-0003-2594-4887
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NR 33
TC 11
Z9 15
U1 0
U2 17
PU KURE ILETISIM GRUBU A S
PI ISTANBUL
PA SIRACEVIZLER CAD 43/3 SISLI, ISTANBUL, 34381, TURKEY
SN 1017-7833
J9 KLIN PSIKOFARMAKOL B
JI Klin. Psikofarmakol. Bul.
PD MAR
PY 2014
VL 24
IS 1
BP 76
EP 83
DI 10.5455/bcp.20130925023705
PG 8
WC Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Psychiatry
GA AG7UN
UT WOS:000335624400011
DA 2025-06-11
ER

PT J
AU Su, ZQ
   Nie, YT
   Huang, XF
   Zhu, Y
   Feng, B
   Tang, LP
   Zheng, GJ
AF Su, Zuqing
   Nie, Yutong
   Huang, Xiufang
   Zhu, Ying
   Feng, Bing
   Tang, Lipeng
   Zheng, Guangjuan
TI Mitophagy in Hepatic Insulin Resistance: Therapeutic Potential and
   Concerns
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Review
DE hepatic insulin resistance; metabolic syndrome; mitochondrial
   dysfunction; hepatic fatty acid accumulation; mitophagy
ID FATTY LIVER-DISEASE; ENDOPLASMIC-RETICULUM STRESS; ACETYL-L-CYSTEINE;
   LIPID-ACCUMULATION; ADIPOSE-TISSUE; OXIDATIVE STRESS; MITOCHONDRIAL
   DYSFUNCTION; METABOLIC SYNDROME; REGULATES MITOPHAGY; ALZHEIMERS-DISEASE
AB Metabolic syndrome, characterized by central obesity, hypertension, and hyperlipidemia, increases the morbidity and mortality of cardiovascular disease, type 2 diabetes, nonalcoholic fatty liver disease, and other metabolic diseases. It is well known that insulin resistance, especially hepatic insulin resistance, is a risk factor for metabolic syndrome. Current research has shown that hepatic fatty acid accumulation can cause hepatic insulin resistance through increased gluconeogenesis, lipogenesis, chronic inflammation, oxidative stress and endoplasmic reticulum stress, and impaired insulin signal pathway. Mitochondria are the major sites of fatty acid beta-oxidation, which is the major degradation mechanism of fatty acids. Mitochondrial dysfunction has been shown to be involved in the development of hepatic fatty acid-induced hepatic insulin resistance. Mitochondrial autophagy (mitophagy), a catabolic process, selectively degrades damaged mitochondria to reverse mitochondrial dysfunction and preserve mitochondrial dynamics and function. Therefore, mitophagy can promote mitochondrial fatty acid oxidation to inhibit hepatic fatty acid accumulation and improve hepatic insulin resistance. Here, we review advances in our understanding of the relationship between mitophagy and hepatic insulin resistance. Additionally, we also highlight the potential value of mitophagy in the treatment of hepatic insulin resistance and metabolic syndrome.
C1 [Su, Zuqing; Nie, Yutong; Huang, Xiufang; Zhu, Ying; Feng, Bing; Tang, Lipeng; Zheng, Guangjuan] Guangzhou Univ Chinese Med, Clin Coll 2, Guangdong Prov Hosp Chinese Med, Guangzhou, Guangdong, Peoples R China.
   [Huang, Xiufang] Guangzhou Univ Chinese Med, Affiliated Hosp 1, Guangzhou, Guangdong, Peoples R China.
C3 Guangzhou University of Chinese Medicine; Guangzhou University of
   Chinese Medicine
RP Zheng, GJ (corresponding author), Guangzhou Univ Chinese Med, Clin Coll 2, Guangdong Prov Hosp Chinese Med, Guangzhou, Guangdong, Peoples R China.
EM zhengguangjuan@gzucm.edu.cn
RI Zheng, Guangjuan/ABB-6496-2020; Tang, Lipeng/ABB-6481-2020
FU National Natural Science Foundation of China [81703770]; Science and
   Technology Planning Project of Guangdong Province, China
   [2014A020221080, 2016A020226048]; Administration of Traditional Chinese
   Medicine of Guangdong Province, China [20172059]; Chinese Medicine
   Scientific Research and Technology Research Projects of Guangdong
   Provincial Hospital of Chinese Medicine [YN2018QJ04, YN2019QJ10];
   Guangdong Provincial Key Laboratory of Chinese Medicine for Prevention
   and Treatment of Refractory Chronic Diseases [2018B030322012]
FX This work was supported by grants from the National Natural Science
   Foundation of China (grant 81703770); the Science and Technology
   Planning Project of Guangdong Province, China (grant 2014A020221080 and
   2016A020226048); the Administration of Traditional Chinese Medicine of
   Guangdong Province, China (grant 20172059); the Chinese Medicine
   Scientific Research and Technology Research Projects of Guangdong
   Provincial Hospital of Chinese Medicine (grant YN2018QJ04 and
   YN2019QJ10); and Guangdong Provincial Key Laboratory of Chinese Medicine
   for Prevention and Treatment of Refractory Chronic Diseases (grant
   2018B030322012).
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NR 179
TC 48
Z9 52
U1 0
U2 24
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD OCT 10
PY 2019
VL 10
AR 1193
DI 10.3389/fphar.2019.01193
PG 15
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA JO4BF
UT WOS:000497523800001
PM 31649547
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Morris, CD
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   May, Mandy G.
   Giese, Alexis A.
TI What Do Persons with Mental Illnesses Need to Quit Smoking? Mental
   Health Consumer and Provider Perspectives
SO PSYCHIATRIC REHABILITATION JOURNAL
LA English
DT Article
DE person centered planning; mental health; addiction; quality of life
ID NICOTINE DEPENDENCE; METABOLIC SYNDROME; SCHIZOPHRENIA; CESSATION;
   TOBACCO; INTERVENTION; PREVALENCE; PREDICTORS; DISORDERS; MORTALITY
AB Objectives: Forty-one percent (41%) of persons in the U.S. who reported having recent mental illnesses also smoke cigarettes. Tobacco use among this population is associated with Up to 25 less years of life and excess medical comorbidity compared to the general population. While research demonstrates that tobacco interventions can be effective for persons with mental illnesses, they are not commonly utilized in clinical practice. The current study explored how to adapt evidence-based tobacco cessation interventions to meet the unique physiological, psychological, and social challenges facing persons with mental illnesses. Methods: Ten focus groups were conducted utilizing a semi-structured discussion; 5 for adult mental health consumers (n = 62) and 5 with mental health clinicians and administrators (n = 22). Content analysis was used to organize themes into categories. Results: Five thematic categories were found: (1) Barriers to treatment, (2) Resources and infrastructure, (3) Negative influences on smoking behavior, (4) Knowledge deficits, and (5) Treatment needs. Conclusions: These findings are instructive in developing appropriate tobacco cessation services for this population. Specifically, these data have been incorporated into a mental health provider toolkit for smoking cessation and have informed the development of a tobacco cessation intervention study.
C1 [Morris, Chad D.] Univ Colorado Denver, Dept Psychiat, Aurora, CO 80045 USA.
C3 University of Colorado System; University of Colorado Anschutz Medical
   Campus; Children's Hospital Colorado
RP Morris, CD (corresponding author), Univ Colorado Denver, Dept Psychiat, 1784 Racine St,Campus Box F478, Aurora, CO 80045 USA.
EM Chad.Morris@UCDenver.edu
RI Waxmonsky, Jeanette/L-4739-2013
OI Waxmonsky, Jeanette/0000-0003-4198-9217
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NR 50
TC 48
Z9 52
U1 0
U2 16
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 1095-158X
EI 1559-3126
J9 PSYCHIATR REHABIL J
JI Psychiatr. Rehabil. J.
PD SPR
PY 2009
VL 32
IS 4
BP 276
EP 284
DI 10.2975/32.4.2009.276.284
PG 9
WC Psychiatry; Rehabilitation
WE Social Science Citation Index (SSCI)
SC Psychiatry; Rehabilitation
GA 435LU
UT WOS:000265346200006
PM 19346206
DA 2025-06-11
ER

PT J
AU Lanza, GA
   Crea, F
AF Lanza, Gaetano Antonio
   Crea, Filippo
TI Primary Coronary Microvascular Dysfunction Clinical Presentation,
   Pathophysiology, and Management
SO CIRCULATION
LA English
DT Review
DE angina; ischemia; microcirculation; syndrome X
ID CARDIAC SYNDROME-X; SLOW FLOW PHENOMENON; CARDIOVASCULAR
   MAGNETIC-RESONANCE; EXERCISE-INDUCED ANGINA; ST-SEGMENT DEPRESSION;
   TERM-FOLLOW-UP; CHEST-PAIN; MYOCARDIAL-PERFUSION; ENDOTHELIAL FUNCTION;
   ARTERY-DISEASE
C1 [Lanza, Gaetano Antonio; Crea, Filippo] Univ Cattolica Sacro Cuore, Ist Cardiol, Rome, Italy.
C3 Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli
RP Lanza, GA (corresponding author), Univ Cattolica Sacro Cuore, Ist Cardiol, Largo A Gemelli 8, Rome, Italy.
EM g.a.lanza@rm.unicatt.it
RI Crea, Filippo/AAC-9754-2022; Lanza, Gaetano/AAC-2660-2019
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NR 62
TC 342
Z9 373
U1 0
U2 30
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0009-7322
EI 1524-4539
J9 CIRCULATION
JI Circulation
PD JUN 1
PY 2010
VL 121
IS 21
BP 2317
EP 2325
DI 10.1161/CIRCULATIONAHA.109.900191
PG 9
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 603MQ
UT WOS:000278213100009
PM 20516386
OA Bronze
DA 2025-06-11
ER

PT J
AU Avrahamy, H
   Shoval, G
   Hoshen, M
   Balicer, RD
   Kamhi-Nesher, S
   Zalsman, G
   Weizman, A
   Krivoy, A
AF Avrahamy, Hamutal
   Shoval, Gal
   Hoshen, Moshe
   Balicer, Ran D.
   Kamhi-Nesher, Shiri
   Zalsman, Gil
   Weizman, Abraham
   Krivoy, Amir
TI Association between Adherence to SSRI Treatment and Mortality among
   Individuals with Metabolic Syndrome Components
SO PHARMACOPSYCHIATRY
LA English
DT Article
DE antidepressants; all-cause mortality; adherence; psychopharmacology;
   pharmacoepidemiology
AB Introduction Depression and anxiety have been associated with type 2 diabetes mellitus and metabolic syndrome, major causes of cardiovascular morbidity and mortality. The effect of antidepressants in this association is unknown. This study aimed to examine the association between adherence to selective serotonin receptor inhibitors (SSRIs) and all-cause mortality among individuals with metabolic syndrome components (hypertension, obesity, and diabetes mellitus).
   Methods Data on 201777 patients who were prescribed SSRIs during the years 2008-2011 were analyzed retrospectively. Adherence was measured using prescription purchase records. The moderating effect of SSRI and statin adherence on the association between metabolic syndrome load and mortality hazard risk (HR) during the study period were analyzed. The Cox-proportional hazard model adjusted to background variables was used to this end.
   Results During the study period, the maximal metabolic load was associated with mortality HR=1.89 (95% CI: 1.79-2) compared to participants without metabolic risk factors. A slight reduction in mortality HR was demonstrated among those with low and moderate SSRI adherence rates. Adherence to statins was negatively associated with the risk of mortality across all levels of adherence. A significant association (r=0.214, p<0.01) was found between adherence to statins and adherence to SSRIs, with higher rates of adherence to statins across all metabolic load categories.
   Discussion While a high metabolic load is associated with a higher risk of mortality, adherence to SSRIs only partially moderated the risk of mortality, in contrast to the protective effect of statins. Adherence differences to statins and SSRIs among individuals prescribed both medications merit further investigation.
C1 [Avrahamy, Hamutal; Shoval, Gal; Kamhi-Nesher, Shiri; Zalsman, Gil; Weizman, Abraham; Krivoy, Amir] Geha Mental Hlth Ctr, Helsinki 1st, IL-491000 Petah Tiqwa, Israel.
   [Shoval, Gal; Kamhi-Nesher, Shiri; Zalsman, Gil; Weizman, Abraham; Krivoy, Amir] Tel Aviv Univ, Sackler Fac Med, Ramat Aviv, Israel.
   [Shoval, Gal; Hoshen, Moshe; Balicer, Ran D.; Krivoy, Amir] Clalit Hlth Serv, Clalit Res Inst, Tel Aviv, Israel.
   [Balicer, Ran D.] Ben Gurion Univ Negev, Fac Hlth Sci, Publ Hlth Dept, Beer Sheva, Israel.
   [Weizman, Abraham] Felsenstein Med Res Ctr, Lab Biol Psychiat, Petah Tiqwa, Israel.
   [Krivoy, Amir] Kings Coll London, Inst Psychiat Psychol & Neurosci, Psychosis Studies Dept, London, England.
C3 Tel Aviv University; Tel Aviv University; Sackler Faculty of Medicine;
   Clalit Health Services; Ben-Gurion University of the Negev; Tel Aviv
   University; University of London; King's College London
RP Avrahamy, H (corresponding author), Geha Mental Hlth Ctr, Helsinki 1st, IL-491000 Petah Tiqwa, Israel.
EM hamutalgold@gmail.com
RI Hoshen, Moshe/HOH-9033-2023; Weizman, Abraham/AAK-6450-2020
OI Weizman, Abraham/0000-0002-9765-8938; Balicer, Ran/0000-0002-7783-6362
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TC 5
Z9 5
U1 0
U2 2
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0176-3679
EI 1439-0795
J9 PHARMACOPSYCHIATRY
JI Pharmacopsychiatry
PD SEP
PY 2021
VL 54
IS 05
BP 232
EP 239
DI 10.1055/a-1425-7246
EA APR 2021
PG 8
WC Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Pharmacology & Pharmacy; Psychiatry
GA UP9EV
UT WOS:000640016600001
PM 33853176
DA 2025-06-11
ER

PT J
AU Tripathi, YB
   Pandey, V
AF Tripathi, Yamini B.
   Pandey, Vivek
TI Obesity and endoplasmic reticulum (ER) stresses
SO FRONTIERS IN IMMUNOLOGY
LA English
DT Review
DE ER stress; mitochondrial stress; obesity; inflammation; metabolic
   syndrome
AB In obesity, the adipose cells behave as inflammatory source and result to low grade inflammation. This systemic inflammation along with oxidative stress is a silent killer and damages other vital organs also High metabolic process, induced due to high nutritional intake, results to endoplasmic reticulum (ER) stress and mitochondnal stress. This review describes the triggering factor and basic mechanism behind the obesity mediated these stresses in relation to inflammation. Efforts have been made to describe the effect-response cycle between ad pocytes and non-adipocyte cells with reference to metabolic syndrome (MS).
C1 [Tripathi, Yamini B.; Pandey, Vivek] Banaras Hindu Univ, Inst Med Sci, Dept Med Chem, Varanasi 221005, Uttar Pradesh, India.
C3 Banaras Hindu University (BHU)
RP Tripathi, YB (corresponding author), Banaras Hindu Univ, Inst Med Sci, Dept Med Chem, Varanasi 221005, Uttar Pradesh, India.
EM yaminiok@yahoo.com
RI Tripathi, Yamini/Q-6160-2019
OI Tripathi, Prof. Yamini Bhusan/0000-0002-8093-1109
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NR 85
TC 48
Z9 55
U1 0
U2 12
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA PO BOX 110, EPFL INNOVATION PARK, BUILDING I, LAUSANNE, 1015,
   SWITZERLAND
SN 1664-3224
J9 FRONT IMMUNOL
JI Front. Immunol.
PY 2012
VL 3
AR 240
DI 10.3389/fimmu.2012.00240
PG 9
WC Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology
GA V40TQ
UT WOS:000209501300235
PM 22891067
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU He, Z
   Dong, L
   Zhang, Y
   Kong, Q
   Tan, G
   Zhou, J
AF He, Z.
   Dong, L.
   Zhang, Y.
   Kong, Q.
   Tan, G.
   Zhou, J.
TI Metabolic syndrome in female migraine patients is associated with
   medication overuse headache: a clinic-based study in China
SO EUROPEAN JOURNAL OF NEUROLOGY
LA English
DT Article
DE cardiovascular disease; female; medication overuse headache; metabolic
   syndrome; migraine
ID BODY-MASS INDEX; CARDIOVASCULAR-DISEASE; INSULIN-RESISTANCE;
   RISK-FACTORS; PREVALENCE; HEALTH; WOMEN; DEPRESSION; PREDICTORS; ANXIETY
AB Background and purposeMigraine and metabolic syndrome have been reported to coexist to a marked degree, especially in women migraine patients, but the relationship between these two conditions is still unclear. This study was performed to evaluate the association of headache characteristics and its comorbidities with metabolic syndrome (MetS) and its components in female migraine patients.
   MethodsA total of 142 women with migraine who fulfilled the criteria of the International Classification of Headache Disorders 2nd edition were recruited in a neurological outpatient department in China. The characteristics of migraine and its comorbidities (analgesic use, psychiatric disorders and disability) were assessed with a detailed questionnaire. Anthropometrics, blood biochemistry and transcranial Doppler sonography were used for metabolic measurements and vascular function.
   ResultsOf 142 participants, 70.4% had one or more metabolic abnormalities and 12.0% had MetS. After adjustment for age, residence, body mass index, waist-to-height ratio, smoking and drinking history, chronic migraine in women patients was associated with MetS [odds ratio (OR)=5.342, P=0.032], but when the chronic migraine patients were comorbid with medication overuse headache (MOH), the risk for MetS increased significantly (OR=12.68, P=0.007). In addition, MOH was associated with abdominal obesity and hypertension amongst the components of MetS (OR=4.205 and 3.234, P=0.043 and 0.039, respectively).
   ConclusionsOur study may suggest that chronic migraine is associated with MetS, especially when it is comorbid with analgesic overuse. MOH may be the risk factor for MetS in female migraine patients and associated with abdominal obesity and hypertension.
C1 [He, Z.; Dong, L.; Zhang, Y.; Kong, Q.; Tan, G.; Zhou, J.] Chongqing Med Univ, Affiliated Hosp 1, Dept Neurol, Chongqing 400016, Peoples R China.
C3 Chongqing Medical University
RP Zhou, J (corresponding author), Chongqing Med Univ, Affiliated Hosp 1, Dept Neurol, 1st You Yi Rd, Chongqing 400016, Peoples R China.
EM zjyheadache@hospital-cqmu.com
RI Dong, Liang/IAR-4638-2023
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NR 32
TC 31
Z9 32
U1 2
U2 9
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1351-5101
EI 1468-1331
J9 EUR J NEUROL
JI Eur. J. Neurol.
PD AUG
PY 2015
VL 22
IS 8
BP 1228
EP 1234
DI 10.1111/ene.12732
PG 7
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA CM5KZ
UT WOS:000357728000014
PM 25981360
DA 2025-06-11
ER

PT J
AU Hur, NW
   Kim, HC
   Waite, L
   Youm, Y
AF Hur, Nam Wook
   Kim, Hyeon Chang
   Waite, Linda
   Youm, Yoosik
TI Is the Relationship between Depression and C Reactive Protein Level
   Moderated by Social Support in Elderly?-Korean Social Life, Health, and
   Aging Project (KSHAP)
SO PSYCHIATRY INVESTIGATION
LA English
DT Article
DE C-reactive protein; Social support; Aged
ID SKELETAL-MUSCLE MASS; EMOTIONAL INTELLIGENCE; INFLAMMATORY MARKERS;
   MENTAL-HEALTH; RELATIONSHIP QUALITY; METABOLIC SYNDROME; OLDER-ADULTS;
   ASSOCIATION; SYMPTOMS; NETWORKS
AB Objective To investigate the buffering effects of social support as an effects modifier in the association between depression and inflammation in the elderly. Methods We analyzed the Korean Social Life, Health, and Aging Project (KSHAP) for questionnaire, clinical, and laboratory data of 530 older adults living in a rural community. Multivariate regression models were used to investigate the association between depressive symptoms and C-reactive protein level (CRP), a marker of inflammation, at varying levels of social support. Results Social support affected the association between depressive symptoms and CRP level in both sexes. However, the direction of effects modification was different for men and women. In men, a higher CRP level was significantly associated with depressive symptoms only among those with lower support from a spouse or family members. By contrast, in women, the association was significant only among subgroups with higher spousal or family support. Social support from neighbors or friends did not affect the depression-inflammation relationship in men but modestly affected the relationship in women. Conclusion Our findings suggest that social support may have a buffering effect in the relationship between depression and inflammation in elderly Koreans. But the influence of social support may run in different directions for men and women.
C1 [Hur, Nam Wook; Youm, Yoosik] Yonsei Univ, Dept Sociol, 50 Yonsei Ro, Seoul 03722, South Korea.
   [Kim, Hyeon Chang] Yonsei Univ, Dept Prevent Med, Seoul, South Korea.
   [Waite, Linda] Univ Chicago, Dept Sociol, Chicago, IL 60637 USA.
C3 Yonsei University; Yonsei University; University of Chicago
RP Youm, Y (corresponding author), Yonsei Univ, Dept Sociol, 50 Yonsei Ro, Seoul 03722, South Korea.
EM yoosik@yonsei.ac.kr
RI YOUM, YOOSIK/KBD-0367-2024; Kim, Hyeon Chang/F-8796-2019
OI Kim, Hyeon Chang/0000-0001-7867-1240; Youm, Yoosik/0000-0003-3822-5777
FU National Research Foundation of Korea [NRF-2017S1A3A2067165]
FX This study was supported by a grant from the National Research
   Foundation of Korea (NRF-2017SIA3A2067165). The authors declare that
   there are no conflicts of interest regarding this study.
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NR 56
TC 8
Z9 8
U1 1
U2 7
PU KOREAN NEUROPSYCHIATRIC ASSOC
PI SEOUL
PA RN 522, G-FIVE CENTRAL PLAZA 1685-8 SEOCHO 4-DONG, SEOCHO-GU, SEOUL,
   137-882, SOUTH KOREA
SN 1738-3684
EI 1976-3026
J9 PSYCHIAT INVEST
JI Psychiatry Investig.
PD JAN
PY 2018
VL 15
IS 1
BP 24
EP 33
DI 10.4306/pi.2018.15.1.24
PG 10
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA FT8IW
UT WOS:000423397400005
PM 29422922
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Pedersen, BK
   Saltin, B
AF Pedersen, B. K.
   Saltin, B.
TI Exercise as medicine - evidence for prescribing exercise as therapy in
   26 different chronic diseases
SO SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
LA English
DT Article
DE physical activity; physical training; type 2 diabetes; cardiovascular;
   cancer; neuropsychiatric
ID QUALITY-OF-LIFE; CHRONIC HEART-FAILURE; POLYCYSTIC OVARIAN SYNDROME;
   RANDOMIZED CONTROLLED-TRIAL; LOW-BACK-PAIN; CARDIOVASCULAR RISK-FACTORS;
   TIME PHYSICAL-ACTIVITY; DEPENDENT DIABETES-MELLITUS; RESTING
   BLOOD-PRESSURE; DENSITY-LIPOPROTEIN CHOLESTEROL
AB This review provides the reader with the up-to-date evidence-based basis for prescribing exercise as medicine in the treatment of 26 different diseases: psychiatric diseases (depression, anxiety, stress, schizophrenia); neurological diseases (dementia, Parkinson's disease, multiple sclerosis); metabolic diseases (obesity, hyperlipidemia, metabolic syndrome, polycystic ovarian syndrome, type 2 diabetes, type 1 diabetes); cardiovascular diseases (hypertension, coronary heart disease, heart failure, cerebral apoplexy, and claudication intermittent); pulmonary diseases (chronic obstructive pulmonary disease, asthma, cystic fibrosis); musculo-skeletal disorders (osteoarthritis, osteoporosis, back pain, rheumatoid arthritis); and cancer. The effect of exercise therapy on disease pathogenesis and symptoms are given and the possible mechanisms of action are discussed. We have interpreted the scientific literature and for each disease, we provide the reader with our best advice regarding the optimal type and dose for prescription of exercise.
C1 [Pedersen, B. K.] Univ Copenhagen, Ctr Inflammat & Metab, Copenhagen, Denmark.
   [Pedersen, B. K.] Univ Copenhagen, Ctr Phys Activ Res, Copenhagen, Denmark.
   [Saltin, B.] Univ Copenhagen, Rigshosp, Copenhagen Muscle Res Ctr, DK-2100 Copenhagen, Denmark.
C3 University of Copenhagen; University of Copenhagen; University of
   Copenhagen; Copenhagen University Hospital; Rigshospitalet
RP Pedersen, BK (corresponding author), Rigshosp, Sect 7641, Blegdamsvej 9, DK-2100 Copenhagen, Denmark.
EM bkp@rh.dk
RI Pedersen, Bente/AGR-3217-2022
OI Pedersen, Bente Klarlund/0000-0001-6508-6288
FU TrygFonden; Capital Region of Denmark
FX This article is based upon a translation and an up-date of our book
   "Fysisk aktivitet - handbog om forebyggelse og behandling" published by
   the National Board of Health, Copenhagen in 2003 and 2011 (ISBN
   87-91232-78-3 (2003) 978-87-7104-243-6 (2011)); available at
   www.sst.dk/publikationer. The Center for Physical Activity Research
   (CFAS) is supported by a grant from TrygFonden. The Copenhagen Muscle
   Research Centre (CMRC) is supported by a grant from the Capital Region
   of Denmark.
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NR 766
TC 1459
Z9 1475
U1 31
U2 941
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0905-7188
EI 1600-0838
J9 SCAND J MED SCI SPOR
JI Scand. J. Med. Sci. Sports
PD DEC
PY 2015
VL 25
SU 3
SI SI
BP 1
EP 72
DI 10.1111/sms.12581
PG 72
WC Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Sport Sciences
GA CW9MN
UT WOS:000365322900001
PM 26606383
OA hybrid
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Daniels, B
   Suzuki, S
   Karavolos, K
   Drees, BM
   Lohse, B
   Bailey-Davis, L
   Nicklas, JM
   Masters, KS
   Powell, LH
AF Daniels, Bryce
   Suzuki, Sumihiro
   Karavolos, Kelly
   Drees, Betty M.
   Lohse, Barbara
   Bailey-Davis, Lisa
   Nicklas, Jacinda M.
   Masters, Kevin S.
   Powell, Lynda H.
TI The Relationships Between Lifestyle Behaviors , Health Perceptions, and
   Psychosocial Outcomes of Metabolic Syndrome Severity
SO DIABETES METABOLIC SYNDROME AND OBESITY
LA English
DT Article
DE metabolic syndrome severity; health; behaviors; metabolic syndrome
   treatment
ID PHYSICAL-ACTIVITY; SUPPORT; ADULTS
AB Purpose: The prevalence of metabolic syndrome (MetS) continues to increase. The severity of MetS can be defined by the number of components or, more recently, a continuous MetS severity score (MetSSS). However, studies that examine lifestyle factors predictive of MetS severity, in general, are lacking. This study aims to compare lifestyle behaviors (eg, physical activity and diet), health perceptions (eg, overall and mental health perceptions), and psychosocial outcomes (eg, perceived stress and social support) among people with a varied number of MetS components and to evaluate associations with MetSSS. Patients and Methods: This cross-sectional study utilized baseline data from a randomized controlled trial of 618 participants with MetS recruited from 5 different sites across the US We collected data using accelerometers, standard questionnaires, bloodwork, and doing physical measurements. We used a series of separate linear regression models (unadjusted and adjusted) to evaluate differences in lifestyle behaviors, health perceptions, and psychosocial factors between people with 3, 4, and 5 MetS components. We conducted additional linear regression models (unadjusted and adjusted) to assess the association between these same variables and a continuous MetSSS. Results: Lifestyle behaviors, health perceptions, and psychosocial factors were not different among people with 3, 4, and 5 MetS components. However, in the adjusted models, a lower MetSSS was associated with more average daily steps (beta = - 631.69, p < 0.001), healthier overall health perception (beta = - 0.14, p = 0.014), more social support for physical activity from friends (beta = - 0.89, p = 0.011) and more social support for healthy eating from friends (beta = - 0.42, p = 0.015). Conclusion: The MetSSS was shown to be more sensitive to modifiable lifestyle factors compared to the number of MetS components, indicating the importance of using the MetSSS in lifestyle interventions targeting MetS to achieve MetS remission.
C1 [Daniels, Bryce; Suzuki, Sumihiro; Karavolos, Kelly; Powell, Lynda H.] Rush Univ, Med Ctr, Family & Preventat Med, Chicago, IL USA.
   [Drees, Betty M.] Univ Missouri, Kansas City Sch Med, Dept Internal Med Biomed & Hlth Informat, Kansas City, MO USA.
   [Lohse, Barbara] Rochester Inst Technol, Wegmans Sch Hlth & Nutr, Rochester, NY USA.
   [Bailey-Davis, Lisa] Geisinger Hlth Syst, Dept Populat Hlth Sci, Danville, PA USA.
   [Nicklas, Jacinda M.] Univ Colorado Denver, Dept Med, Div Internal Med, Anschutz Med Campus, Denver, CO USA.
   [Masters, Kevin S.] Univ Colorado Denver, Dept Psychol, Anschutz Med Campus, Denver, CO USA.
C3 Rush University; University of Missouri System; University of Missouri
   Kansas City; Rochester Institute of Technology; Geisinger Health System;
   Children's Hospital Colorado; University of Colorado System; University
   of Colorado Denver; University of Colorado Anschutz Medical Campus;
   University of Colorado System; University of Colorado Anschutz Medical
   Campus; University of Colorado Denver; Children's Hospital Colorado
RP Daniels, B (corresponding author), Univ Arkansas Syst, Dept Family & Consumer Sci, Div Agr Cooperat Extens Serv, 2301 S Univ Ave, Little Rock, AR 72204 USA.
EM bryce_daniels@rush.edu
FU William G. McGowan Charitable Fund; Rush University Medical Center;
   Rochester Institute of Technology; National Heart Lung and Blood
   Institute at the National Institutes of Health [K23HL133604]; Eli Lilly;
   Novo Nordisk; Cleerly Inc.; McGowan Charitable Fund; Wegman Family
   Charitable Foundation, Inc.
FX The trial was supported by a grant from the William G. McGowan
   Charitable Fund (the Fund) . Supplementary funding was provided by Rush
   University Medical Center and the Rochester Institute of Technology.
   Neither the Fund nor the supplementary funders had any role in design or
   conduct of the trial, the decision to publish trial results, the
   analyses of data, or the preparation of this manuscript. Dr Nicklas was
   funded by a career development award from the National Heart Lung and
   Blood Institute at the National Institutes of Health (K23HL133604) . Dr
   Nicklas is a coinvestigator on weight-loss studies funded by Eli Lilly
   and Novo Nordisk, a primary cardiovascular prevention trial funded by
   Cleerly Inc, and on a metabolic syndrome reversal trial funded by the
   McGowan Charitable Fund. Dr Lohse received support from the Wegman
   Family Charitable Foundation, Inc.
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NR 43
TC 0
Z9 0
U1 0
U2 0
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-7007
J9 DIABET METAB SYND OB
JI Diabetes Metab. Syndr. Obes.
PY 2025
VL 18
BP 1575
EP 1585
DI 10.2147/DMSO.S484850
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 2TK3P
UT WOS:001490877400001
PM 40386348
OA gold
DA 2025-06-11
ER

PT J
AU Wingard, C
   Fulton, D
   Husain, S
AF Wingard, Christopher
   Fulton, David
   Husain, Shahid
TI Altered penile vascular reactivity and erection in the Zucker
   obese-diabetic rat
SO JOURNAL OF SEXUAL MEDICINE
LA English
DT Article
DE smooth muscle; endothelin-1; Rho-kinase; PKC; nitric oxide synthase;
   metabolic syndrome X
ID PROTEIN-KINASE-C; NITRIC-OXIDE SYNTHASE; RHO-KINASE; METABOLIC SYNDROME;
   CORPUS CAVERNOSUM; RHOA/RHO-KINASE; SMOOTH-MUSCLE; INSULIN-RESISTANCE;
   CA2+ SENSITIVITY; VASOCONSTRICTION
AB Introduction. The combination of the independent risk factors for erectile dysfunction, obesity, hypertension, and diabetes are manifested collectively in a condition known as metabolic syndrome X. However, the exact mechanism(s) by which the combination of these factors contributes to erectile dysfunction have yet to be elucidated.
   Aim. We hypothesized that protein kinase C (PKC) and Rho-kinase enhanced vascular tone and thus contributed to erectile dysfunction in this condition.
   Methods. Erectile function was evaluated by recording voltage-dependent increases in intracavernosal pressure following stimulation of the cavernosal nerve in 16- to 20-week-old lean and obese-diabetic Zucker rats. Cavernosal tissue contractile and relaxation responses were evaluated in vitro when contracted with phenylephrine, endothelin-1 and relaxed by Rho-kinase, PKC inhibitors or sodium nitroprusside. Additionally, cavernosal tissue Rho-kinase, protein kinase, and nitric oxide synthase isoform expression were evaluated by Western blot.
   Results. The voltage-dependent erectile responses were suppressed by > 30% in the obese-diabetic Zucker rat. The maximal stress generated by cavernosal tissue from the obese-diabetic was significantly greater than the lean response by greater than 0.8 mN/mm(2) for both phenylephrine and endothelin stimulation. The PKC inhibitor, chelerythrine, inhibited more than 30% of the phenylephrine-induced and 70% of the endothelin-1-induced contractions. Rho-kinase inhibition, with either Y-27632 or HA-1077, revealed impaired relaxations of nearly 30% in tissue from obese-diabetic animals. Western blot analysis revealed increased protein expression of PKC alpha and delta and Rho-kinase alpha and beta but no loss for endothelial or neuronal nitric oxide synthase.
   Conclusions. In this rodent model both PKC and Rho-kinase signaling elements may contribute to an enhanced vasoconstriction state of the penile smooth muscle that was differentially dependent on the agonist used. The enhanced vasoconstrictive state of the tissue could contribute to the reduced voltage-dependent erectile response in the obese-diabetic Zucker rat.
C1 E Carolina Univ Physiol, Brody Sch Med, Greenville, NC 27834 USA.
   Med Coll Georgia Pharmacol, Augusta, GA USA.
   Med Coll S Carolina Ophthalmol, Charleston, SC USA.
C3 University of North Carolina; East Carolina University; University
   System of Georgia; Augusta University
RP Wingard, C (corresponding author), E Carolina Univ Physiol, Brody Sch Med, 600 Moye Blvd,Brody 6E98, Greenville, NC 27834 USA.
EM wingardc@ecu.edu
RI Hussain, Shahid/AAP-5065-2021; Wingard, Christopher/R-5042-2019
OI Wingard, Christopher/0000-0002-8251-5678
FU NIDDK NIH HHS [R01 DK-59467] Funding Source: Medline
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NR 58
TC 73
Z9 77
U1 0
U2 1
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1743-6095
EI 1743-6109
J9 J SEX MED
JI J. Sex. Med.
PD MAR
PY 2007
VL 4
IS 2
BP 348
EP 362
DI 10.1111/j.1743-6109.2007.00439.x
PG 15
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 143SS
UT WOS:000244745300016
PM 17367430
DA 2025-06-11
ER

PT J
AU De Liso, F
   Bonara, P
   Vigna, L
   Novembrino, C
   De Giuseppe, R
   Bamonti, F
   Carbonelli, V
   Frugoni, C
   Tirelli, AS
   Maiavacca, R
   Riboldi, L
AF De Liso, F.
   Bonara, P.
   Vigna, L.
   Novembrino, C.
   De Giuseppe, R.
   Bamonti, F.
   Carbonelli, V.
   Frugoni, C.
   Tirelli, A. S.
   Maiavacca, R.
   Riboldi, L.
TI OXIDATIVE STRESS AND LOW-GRADE INFLAMMATORY STATUS AS. CARDIOMETABOLIC
   RISK FACTORS IN ITALIAN OCCUPATIONAL OVERWEIGHT/OBESE SUBJECTS
SO EUROPEAN JOURNAL OF INFLAMMATION
LA English
DT Article
DE obesity; adipose tissue; inflammation; cytokines; occupational
ID OXIDIZED LDL; OBESITY
AB Obesity is associated with increased risk of cardiometabolic diseases. Adipocytokines (e.g. leptin), produced by the endocrine function of adipose tissue, can contribute to cardiometabolic risk in overweight and obese people. Oxidative stress, imbalance between oxidants and antioxidants, is considered a cardiovascular risk factor. High serum oxidized LDL (oxLDL) levels, marker of lipid peroxidation, a primary cause of atherosclerosis, can contribute to its progression. The aims of this study are to assess markers of oxidative status and cytokine profile and evaluate their role as cardiometabolic risk factors and possible correlations. In this cross-sectional study, we enrolled 76 occupational overweight-obese adults (46 females, 30 males; aged 46.8 +/- 9.5; BMI 33.7 +/- 4.8 kg/m(2)) without any previous cardiovascular disease. Oxidative status was measured by evaluating serum Reactive Oxygen Species (ROS) levels, Total Antioxidant Capacity (TAC) and oxLDL concentrations. All subjects' soluble cytokine and adhesion molecule levels were evaluated by cytofluorimetric method and compared with 35 controls matched for set and age: ROS and oxLDL levels were high in 84% and 92% of the study population, respectively, despite adequate TAC (68%). Female ROS levels were significantly higher than those of males (414 +/- 99.3 vs 318 +/- 48.2 UCarr, p<0.0001), while their oxLDL levels were lower (95.3 +/- 22 vs 105.2 +/- 19.4 U/L, p=0.1). Leptin and sICAM-1 (intracellular adhesion molecule involved in leukocyte migration to inflamed area) levels of the study population were significantly higher than those of controls (93.8 +/- 89.1 vs 25.3 +/- 23 ng/mL, p=0.0002 and 505.8 +/- 236.7 vs 339.2 +/- 119.6 ng/mL, p=0.0009, respectively). Overweight/obese occupational subjects showed oxidative stress conditions accompanied by low chronic inflammatory status, possibly contributing to increased cardiometabolic risk.
C1 [De Liso, F.; De Giuseppe, R.; Bamonti, F.] Univ Milan, Fdn IRCCS Ca Granda Osped Maggiore Policlin, UOC Ematol & CTMO, Dipartimento Sci Biomed Chirurg & Odontoiat, Milan, Italy.
   [Bonara, P.] Fdn IRCCS Ca Granda Osped Maggiore Policlin, UO Med Interna 1B, I-20122 Milan, Italy.
   [Vigna, L.; Riboldi, L.] Fdn IRCCS Ca Granda Osped Maggiore Policlin, UO Med Lavoro 1, Dipartimento Area Med Prevent, I-20122 Milan, Italy.
   [Novembrino, C.; Tirelli, A. S.; Maiavacca, R.] Fdn IRCCS Ca Granda Osped Maggiore Policlin, Lab Cent Anal Chim Clin & Microbiol, I-20122 Milan, Italy.
   [Carbonelli, V.] Univ Milan, Fdn IRCCS Ca Granda Osped Maggiore Policlin, Dipartimento Fisiopatol Medicochirurg & Trapianti, Milan, Italy.
   [Frugoni, C.] Fdn IRCCS Ca Granda Osped Maggiore Policlin, UO Med Trasfus, I-20122 Milan, Italy.
C3 IRCCS Ca Granda Ospedale Maggiore Policlinico; University of Milan;
   IRCCS Ca Granda Ospedale Maggiore Policlinico; IRCCS Ca Granda Ospedale
   Maggiore Policlinico; IRCCS Ca Granda Ospedale Maggiore Policlinico;
   IRCCS Ca Granda Ospedale Maggiore Policlinico; University of Milan;
   IRCCS Ca Granda Ospedale Maggiore Policlinico
RP Vigna, L (corresponding author), Fdn IRCCS Ca Granda Osped Maggiore Policlin, Via F Sforza 35, I-20122 Milan, Italy.
EM luisellavigna@inwind.it
RI ; De Giuseppe, Rachele/K-4899-2018
OI Vigna, Luisella/0000-0001-5014-721X; De Giuseppe,
   Rachele/0000-0002-5583-7735
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NR 20
TC 6
Z9 6
U1 0
U2 0
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1721-727X
EI 2058-7392
J9 EUR J INFLAMM
JI Eur. J. Inflamm.
PD SEP-DEC
PY 2013
VL 11
IS 3
BP 789
EP 796
DI 10.1177/1721727X1301100321
PG 8
WC Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology
GA 287HS
UT WOS:000329533300021
DA 2025-06-11
ER

PT J
AU Young, SJ
   Praskova, A
   Hayward, N
   Patterson, S
AF Young, Sarah J.
   Praskova, Anna
   Hayward, Nicky
   Patterson, Sue
TI Attending to physical health in mental health services in Australia: a
   qualitative study of service users' experiences and expectations
SO HEALTH & SOCIAL CARE IN THE COMMUNITY
LA English
DT Article
DE cardiovascular; expectations; patients; physical health; qualitative;
   service users; severe mental health problems
ID CORONARY-HEART-DISEASE; METABOLIC SYNDROME; PEOPLE; ILLNESS;
   SCHIZOPHRENIA; INFORMATION; PREVALENCE; BEHAVIORS; CONSUMERS; RISK
AB Evidence is unequivocal: the premature death of people with severe mental health problems is attributable primarily to cardiovascular disease, and healthcare provided is often suboptimal. With the overarching aim of improving outcomes, policies and guidelines oblige mental health services and psychiatrists to monitor cardio-metabolic health of patients and intervene as appropriate. Practice is highly variable; however, with ongoing debate about resourcing and responsibilities dominated by clinicians who have identified disinterest among patients as influencing practice. Seeking to balance discussion, we posed the question 'what do patients experience and expect of mental health services in relation to their physical health?' To answer it, we interviewed a convenience sample of 40 service users recruited from a mental health service in Australia, early in 2015. Data were analysed using the framework approach. With few regarding themselves as healthy, participants were commonly concerned about side effects of medication, weight and fitness but rarely mentioned tobacco smoking. Participants' accounts reinforce extensive research demonstrating variability in attention to physical health in mental health services. Reports by some participants of comprehensive care are encouraging, but widespread uncertainty about reasons for various assessments and denial of requests for management of medication side effects, including weight gain, gives cause for concern. Although participants in this study wanted to improve their health and health-related quality of life, they acknowledged that their motivation and ability to do so fluctuated with mental health. They expected clinicians to work proactively, especially when symptoms compromised capacity for self-care, and mental health services to provide or enable access to health-promoting interventions. Attention should be given, as a matter of priority, to creating conditions (culture and infrastructure) needed to support sustained attention to physical health within services and, importantly, to full engagement of service users in management of their physical health.
C1 [Young, Sarah J.; Praskova, Anna; Patterson, Sue] Metro North Hosp & Hlth Serv, Metro North Mental Hlth, Brisbane, Qld, Australia.
   [Praskova, Anna; Patterson, Sue] Griffith Univ, Appl Psychol, Nathan, Qld, Australia.
C3 Griffith University
RP Patterson, S (corresponding author), Royal Brisbane & Womens Hosp, Mental Hlth Ctr, Brisbane, Qld 4029, Australia.
EM susan.patterson@health.qld.gov.au
RI Praskova, Anna/AAB-1183-2019
OI Praskova, Dr Anna/0000-0002-6436-5100
FU Caboolture Hospital Innovation and Research Program
FX We are grateful to the clinicians who conducted interviews (Nicole
   Brigg, Anita Compton, Judy Lawrance) and service managers and clinicians
   who supported the study by facilitating researcher access to study sites
   and potential participants. Particular thanks to the service users who
   generously gave their time and shared their views making this study
   possible. We are also grateful to the anonymous reviewers whose
   constructive critique supported improvement of the paper and clinician
   colleagues Nadine McKenzie and Michelle Carter-Mangan for helpful
   comments during revision. This study was funded in part by the
   Caboolture Hospital Innovation and Research Program and conducted with
   in-kind support of Metro North Mental Health, Metro North Hospital and
   Health Service.
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NR 39
TC 28
Z9 30
U1 0
U2 8
PU WILEY-HINDAWI
PI LONDON
PA ADAM HOUSE, 3RD FL, 1 FITZROY SQ, LONDON, WIT 5HE, ENGLAND
SN 0966-0410
EI 1365-2524
J9 HEALTH SOC CARE COMM
JI Health Soc. Care Community
PD MAR
PY 2017
VL 25
IS 2
BP 602
EP 611
DI 10.1111/hsc.12349
PG 10
WC Public, Environmental & Occupational Health; Social Work
WE Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; Social Work
GA EL9YS
UT WOS:000394976600029
PM 27093882
OA gold
DA 2025-06-11
ER

PT J
AU Booz, GW
AF Booz, George W.
TI Cannabidiol as an emergent therapeutic strategy for lessening the impact
   of inflammation on oxidative stress
SO FREE RADICAL BIOLOGY AND MEDICINE
LA English
DT Review
DE Inflammation; Oxidative stress; Immune system; Metabolic syndrome;
   Endocannabinoid; Free radicals
ID EQUILIBRATIVE NUCLEOSIDE TRANSPORTER; NF-KAPPA-B; CELL-DEATH;
   ENDOCANNABINOID SYSTEM; CANNABINOID RECEPTORS; INDUCED APOPTOSIS;
   NEUROPATHIC PAIN; ALZHEIMERS-DISEASE; NITRIC-OXIDE; ACTIVATION
AB Oxidative stress with reactive oxygen species generation is a key weapon in the arsenal of the immune system for fighting invading pathogens and initiating tissue repair. If excessive or unresolved, however, immune-related oxidative stress can initiate further increasing levels of oxidative stress that cause organ damage and dysfunction. Targeting oxidative stress in various diseases therapeutically has proven more problematic than first anticipated given the complexities and perversity of both the underlying disease and the immune response. However, growing evidence suggests that the endocannabinoid system, which includes the CB1 and CB2 G-protein-coupled receptors and their endogenous lipid ligands, may be an area that is ripe for therapeutic exploitation. In this context, the related nonpsychotropic cannabinoid cannabidiol, which may interact with the endocannabinoid system but has actions that are distinct, offers promise as a prototype for anti-inflammatory drug development This review discusses recent studies suggesting that cannabidiol may have utility in treating a number of human diseases and disorders now known to involve activation of the immune system and associated oxidative stress, as a contributor to their etiology and progression. These include rheumatoid arthritis, types 1 and 2 diabetes, atherosclerosis, Alzheimer disease, hypertension, the metabolic syndrome, ischemia-reperfusion injury, depression, and neuropathic pain. (C) 2011 Elsevier Inc. All rights reserved.
C1 [Booz, George W.] Univ Mississippi, Dept Pharmacol & Toxicol, Sch Med, Med Ctr, Jackson, MS 39216 USA.
   [Booz, George W.] Univ Mississippi, Med Ctr, Ctr Excellence Cardiovasc Renal Res, Jackson, MS 39216 USA.
C3 University of Mississippi; University of Mississippi Medical Center;
   University of Mississippi; University of Mississippi Medical Center
RP Booz, GW (corresponding author), Univ Mississippi, Dept Pharmacol & Toxicol, Sch Med, Med Ctr, Jackson, MS 39216 USA.
EM gbooz@umc.edu
FU National Heart, Lung, and Blood Institute [R01HL088101-04,
   R01HL088101-02S1]
FX This work was supported by grants from the National Heart, Lung, and
   Blood Institute (R01HL088101-04 and R01HL088101-02S1).
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NR 101
TC 189
Z9 207
U1 1
U2 57
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0891-5849
EI 1873-4596
J9 FREE RADICAL BIO MED
JI Free Radic. Biol. Med.
PD SEP 1
PY 2011
VL 51
IS 5
SI SI
BP 1054
EP 1061
DI 10.1016/j.freeradbiomed.2011.01.007
PG 8
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 810RE
UT WOS:000294144000013
PM 21238581
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Prochaska, JJ
   Fromont, SC
   Delucchi, K
   Young-Wolff, KC
   Benowitz, NL
   Hall, S
   Bonas, T
   Hall, SM
AF Prochaska, Judith J.
   Fromont, Sebastien C.
   Delucchi, Kevin
   Young-Wolff, Kelly C.
   Benowitz, Neal L.
   Hall, Stephen
   Bonas, Thomas
   Hall, Sharon M.
TI Multiple Risk-Behavior Profiles of Smokers With Serious Mental Illness
   and Motivation for Change
SO HEALTH PSYCHOLOGY
LA English
DT Article
DE multiple risk behaviors; stage of change; mental illness; tobacco
ID SMOKING-CESSATION; CIGARETTE-SMOKING; HEALTH-CARE; TOBACCO CESSATION;
   CARDIOMETABOLIC RISK; NICOTINE DEPENDENCE; DEPRESSED SMOKERS;
   PHYSICAL-ACTIVITY; FAGERSTROM TEST; SHORT-FORM
AB Objective: Individuals with serious mental illness (SMI) are dying on average 25 years prematurely. The leading causes are chronic preventable diseases. In the context of a tobacco-treatment trial, this exploratory study examined the behavioral risk profiles of adults with SMI to identify broader interventional needs. Method: Recruited from five acute inpatient psychiatry units, participants were 693 adult smokers (recruitment rate = 76%, 50% male, 45% Caucasian, age M = 39, 49% had income < $10,000) diagnosed with mood disorders (71%), substance-use disorders (63%), posttraumatic stress disorder (39%), psychotic disorders (25%), and attention deficit-hyperactivity disorder (25%). The Staging Health Risk Assessment, the primary measure used in this study, screened for risk status and readiness to change 11 health behaviors, referencing the period prior to acute hospitalization. Results: Participants averaged 5.2 (SD = 2.1) risk behaviors, including smoking (100%), high-fat diet (68%), inadequate fruits/vegetables (67%), poor sleep (53%), physical inactivity (52%), and marijuana use (46%). The percent prepared to change ranged from 23% for tobacco and marijuana to 76% for depression management. Latent class analysis differentiated three risk groups: the global higher risk group included patients elevated on all risk behaviors; the global lower risk group was low on all risks; and a mood and metabolic risk group, characterized by inactivity, unhealthy diet, sleep problems, and poor stress and depression management. The global higher risk group (11% of sample) was younger, largely male, and had the greatest number of risk behaviors and mental health diagnoses; had the most severe psychopathologies, addiction-treatment histories, and nicotine dependence; and the lowest confidence for quitting smoking and commitment to abstinence. Conclusion: Most smokers with SMI engaged in multiple risks. Expanding targets to treat co-occurring risks and personalizing treatment to individuals' multibehavioral profiles may increase intervention relevance, interest, and impact on health.
C1 [Prochaska, Judith J.; Young-Wolff, Kelly C.; Benowitz, Neal L.] Stanford Univ, Dept Med, Stanford Prevent Res Ctr, Stanford, CA 94305 USA.
   [Fromont, Sebastien C.; Delucchi, Kevin; Hall, Stephen; Hall, Sharon M.] Univ Calif San Francisco, Dept Psychiat, San Francisco, CA USA.
   [Benowitz, Neal L.] Univ Calif San Francisco, Dept Med, Div Clin Pharmacol, San Francisco, CA USA.
   [Benowitz, Neal L.] Univ Calif San Francisco, Dept Bioengn & Therapeut Sci, Div Clin Pharmacol, San Francisco, CA 94143 USA.
   [Bonas, Thomas] Herrick, Alta Bates Summit Med Ctr, Berkeley, CA USA.
C3 Stanford University; University of California System; University of
   California San Francisco; University of California System; University of
   California San Francisco; University of California System; University of
   California San Francisco
RP Prochaska, JJ (corresponding author), Stanford Univ, Med Sch Off Bldg,X316,1265 Welch Rd, Stanford, CA 94305 USA.
EM JPro@Stanford.edu
RI Prochaska, Judith/I-4510-2013
OI Prochaska, Judith/0000-0001-7925-326X
FU United States Department of Health and Human Services, National
   Institutes of Health, National Institute of Mental Health [R01
   MH083684]; National Institute on Drug Abuse [K23 DA018691, K05 DA016752,
   P50 DA09253]; State of California Tobacco-Related Disease Research
   Program [21BT-0018]
FX This work was supported by the United States Department of Health and
   Human Services, National Institutes of Health, National Institute of
   Mental Health Grant R01 MH083684; National Institute on Drug Abuse
   Grants K23 DA018691, K05 DA016752, and P50 DA09253; and the State of
   California Tobacco-Related Disease Research Program Grant 21BT-0018;
   ClinicalTrials.gov registry No. NCT00968513.
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NR 79
TC 25
Z9 28
U1 0
U2 38
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 0278-6133
EI 1930-7810
J9 HEALTH PSYCHOL
JI Health Psychol.
PD DEC
PY 2014
VL 33
IS 12
BP 1518
EP 1529
DI 10.1037/a0035164
PG 12
WC Psychology, Clinical; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology
GA AU6WK
UT WOS:000345741900008
PM 24467257
OA Green Accepted, Green Published
DA 2025-06-11
ER

PT J
AU Bespalova, ID
   Romanov, DS
   Denisova, OA
   Bragina, EY
   Koshchavtseva, Y
   Mitrichenko, UM
   Teteneva, A
   Kalyuzhina, E
   Porovskiy, Y
   Bukreeva, EB
AF Bespalova, I. D.
   Romanov, D. S.
   Denisova, O. A.
   Bragina, E. Yu
   Koshchavtseva, Yu., I
   Mitrichenko, U. M.
   Teteneva, A., V
   Kalyuzhina, E., V
   Porovskiy, Ya., V
   Bukreeva, E. B.
TI Sarcoidosis as a disease associated with metabolic syndrome
SO BYULLETEN SIBIRSKOY MEDITSINY
LA English
DT Review
DE sarcoidosis; metabolic syndrome; obesity; atherosclerosis; diabetes
   mellitus; dyslipidemia
ID BODY-MASS INDEX; OBSTRUCTIVE SLEEP-APNEA; OXIDATIVE STRESS; OBESITY;
   RISK; WOMEN; PHYSIOLOGY; DRIVE
AB The review summarizes and analyzes the results of domestic and major foreign studies of recent years concerning the prevalence of metabolic syndrome components and the explanation of their role in the mechanisms of sarcoidosis development. A deep understanding of the pathogenesis of metabolic syndrome (MS) in terms of the role in it of risk factors for a severe course and complications of most socially sensitive noncommunicable diseases clustered within MS can underly the development of effective pathogen-specific approaches to MS treatment.
C1 [Bespalova, I. D.; Romanov, D. S.; Denisova, O. A.; Koshchavtseva, Yu., I; Mitrichenko, U. M.; Teteneva, A., V; Kalyuzhina, E., V; Porovskiy, Ya., V; Bukreeva, E. B.] Siberian State Med Univ, 2 Moscow Trakt, Tomsk 634050, Russia.
   [Bragina, E. Yu] Russian Acad Sci, Tomsk Natl Res Med Ctr NRMC, Res Inst Med Genet, 10 Ushaika River Embankment, Tomsk 634050, Russia.
C3 Siberian State Medical University; Russian Academy of Sciences; Tomsk
   National Research Medical Center; Research Institute of Medical Genetics
   - Tomsk
RP Bespalova, ID (corresponding author), Siberian State Med Univ, 2 Moscow Trakt, Tomsk 634050, Russia.
EM innadave@mail2000.ru; romanovds92@yandex.ru; oadeni@yandex.ru;
   elena.bragina@medgenetics.ru; strashkovaum@gmail.com; kbukreeva@mail.ru
RI Bukreeva, Ekaterina/M-9929-2016; Bragina, Elena/A-8049-2014
OI Pashkovskaya, Daria/0000-0002-0471-5084; Kosavceva,
   Ulia/0000-0001-5260-4832; Mitrichenko, Uliana/0000-0001-6091-4849;
   Romanov, Dmitrii/0009-0002-2028-4963; Bragina,
   Elena/0000-0002-1103-3073; Ekaterina, Bukreeva/0000-0002-7699-5492;
   Pal'cikova, Inna Aleksandrovna/0000-0003-4968-1110
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NR 66
TC 1
Z9 1
U1 0
U2 0
PU SIBERIAN STATE MEDICAL UNIV
PI TOMSK
PA UL LENINA 107, TOMSK, 63405, RUSSIA
SN 1682-0363
EI 1819-3684
J9 BYULLETEN SIB MED
JI BYULLETEN SIB. MED.
PY 2023
VL 22
IS 3
BP 80
EP 87
DI 10.20538/1682-0363-2023-3-80-87
PG 8
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA X4MD0
UT WOS:001098199800010
OA gold
DA 2025-06-11
ER

PT J
AU Hervieu, GJ
AF Hervieu, GJ
TI Further insights into the neurobiology of melanin-concentrating hormone
   in energy and mood balances
SO EXPERT OPINION ON THERAPEUTIC TARGETS
LA English
DT Review
DE antagonist; anxiety; depression; energy regulation;
   melanin-concentrating hormone (MCH); MCH receptor; MCH1R; MCH2R;
   obesity; stress
ID MESSENGER-RIBONUCLEIC-ACID; PROTEIN-COUPLED RECEPTORS; PITUITARY-ADRENAL
   AXIS; BROWN ADIPOSE-TISSUE; EVALUATION IN-VITRO; FOOD-INTAKE;
   FEEDING-BEHAVIOR; ALPHA-MSH; 2-AMINO-8-ALKOXY QUINOLINES; HYPOTHALAMIC
   NEUROPEPTIDES
AB Melanin-concentrating hormone (MCH) is a critical hypothalamic anabolic neuropeptide, with key central and peripheral actions on energy balance regulation. The actions of MCH are, so far, known to be transduced through two seven-transmembrane-like receptor paralogues, named MCH1R and MCH2R. MCH2R is not functional in rodents. MCH1R is an important receptor involved in mediating feeding behaviour modulation by MCH in rodents. Pharmacological antagonism at MCH1R in rodents diminishes food intake and results in significant and sustained weight loss in fat tissues, particularly in obese animals. Additionally, MCH1R antagonists have been shown to have anxiolytic and antidepressant properties. The purpose of this review is to highlight the recent numerous pieces of evidence showing that pharmacological blockade at MCH1R could be a potential treatment for obesity and its related metabolic syndrome, as well as for various psychiatric disorders.
C1 GlaxoSmithKline, R&D, Neurol Ctr Excellence Drug Discovery, Harlow CM19 5AW, Essex, England.
C3 GlaxoSmithKline; Glaxosmithkline United Kingdom
RP GlaxoSmithKline, R&D, Neurol Ctr Excellence Drug Discovery, NFSP N,HW1713,Bldg H17,L1-130 C06 3rd Ave, Harlow CM19 5AW, Essex, England.
EM gjhervieu@hotmail.com
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NR 188
TC 26
Z9 28
U1 0
U2 1
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1472-8222
EI 1744-7631
J9 EXPERT OPIN THER TAR
JI Expert Opin. Ther. Targets
PD APR
PY 2006
VL 10
IS 2
BP 211
EP 229
DI 10.1517/14728222.10.2.211
PG 19
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 030OW
UT WOS:000236645100003
PM 16548771
DA 2025-06-11
ER

PT J
AU Kaya, A
   Uzunhasan, I
   Baskurt, M
   Ozkan, A
   Ataoglu, E
   Okcun, B
   Yigit, Z
AF Kaya, Aysem
   Uzunhasan, Isil
   Baskurt, Murat
   Ozkan, Alev
   Ataoglu, Esra
   Okcun, Baris
   Yigit, Zerrin
TI Oxidative Status and Lipid Profile in Metabolic Syndrome: Gender
   Differences
SO METABOLIC SYNDROME AND RELATED DISORDERS
LA English
DT Article
ID TOTAL ANTIOXIDANT CAPACITY; C-REACTIVE PROTEIN; CARDIOVASCULAR-DISEASE;
   FREE-RADICALS; STRESS; OBESITY
AB Background: Metabolic syndrome is associated with cardiovascular disease and oxidative stress. The aim of this study was to investigate the differences of novel oxidative stress parameters and lipid profiles in men and women with metabolic syndrome.
   Methods: The study population included 88 patients with metabolic syndrome, consisting of 48 postmenopausal women (group I) and 40 men (group II). Premenopausal women were excluded. Plasma levels of total antioxidant status (TAS) and total oxidative status (TOS) were determined by using the Erel automated measurement method, and oxidative stress index (OSI) was calculated. To perform the calculation, the resulting unit of TAS, mmol Trolox equivalent/L, was converted to mu mol equivalent/L and the OSI value was calculated as: OSI = [(TOS, mu mol/L)/(TAS, mmol Trolox equivalent/L) x 100]. The Student t-test, Mann-Whitney-U test, and chi-squared test were used for statistical analysis; the Pearson correlation coefficient and Spearman rank test were used for correlation analysis. P <= 0.05 was considered to be statistically significant.
   Results: Both women and men had similar properties regarding demographic characteristics and biochemical work up. Group II had significantly lower levels of antioxidant levels of TAS and lower levels of TOS and OSI compared with group I (P = 0.0001, P = 0.0035, and P = 0,0001). Apolipoprotein A (ApoA) levels were significantly higher in group I compared with group II.
   Conclusions: Our findings indicate that women with metabolic syndrome have a better antioxidant status and higher ApoA levels compared with men. Our findings suggest the existence of a higher oxidative stress index in men with metabolic syndrome. Considering the higher risk of atherosclerosis associated with men, these novel oxidative stress parameters may be valuable in the evaluation of patients with metabolic sydrome.
C1 [Kaya, Aysem; Uzunhasan, Isil; Baskurt, Murat; Ozkan, Alev; Okcun, Baris; Yigit, Zerrin] Istanbul Univ, Dept Biochem, Inst Cardiol, TR-34303 Istanbul, Turkey.
   [Ataoglu, Esra] Haseki Educ & Training Hosp, Dept Internal Med, Istanbul, Turkey.
C3 Istanbul University; Istanbul Haseki Training & Research Hospital
RP Uzunhasan, I (corresponding author), Istanbul Univ, Dept Biochem, Inst Cardiol, TR-34303 Istanbul, Turkey.
EM isil.uzunhasan@gmail.com
RI Uzunhasan, Isil/D-8376-2019; Ataoğlu, Hayriye Esra/AAD-5627-2019; Kaya,
   Aysem/N-4974-2015; Ökçün, Barış/D-8295-2019; Arat-Ozkan,
   Alev/A-8073-2016
OI Ataoglu, Hayriye Esra/0000-0002-6559-2575; Kaya,
   Aysem/0000-0003-3137-821X; Arat-Ozkan, Alev/0000-0001-8064-7231
CR Abdel-Naeem Nareman M., 2005, Journal of the Egyptian Society of Parasitology, V35, P1173
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NR 25
TC 13
Z9 14
U1 0
U2 9
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-4196
EI 1557-8518
J9 METAB SYNDR RELAT D
JI Metab. Syndr. Relat. Disord.
PD FEB
PY 2010
VL 8
IS 1
BP 53
EP 57
DI 10.1089/met.2009.0004
PG 5
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 559SE
UT WOS:000274846200008
PM 19958158
DA 2025-06-11
ER

PT J
AU Limberg, JK
   Morgan, BJ
   Schrage, WG
AF Limberg, Jacqueline K.
   Morgan, Barbara J.
   Schrage, William G.
TI Peripheral Blood Flow Regulation in Human Obesity and Metabolic Syndrome
SO EXERCISE AND SPORT SCIENCES REVIEWS
LA English
DT Review
DE exercise; skeletal muscle; functional sympatholysis;
   endothelium-dependent vasodilation; muscle sympathetic nerve activity;
   oxidative stress
ID SKELETAL-MUSCLE PERFUSION; NEURAL-CONTROL; ZUCKER RATS; ADRENERGIC
   RESPONSIVENESS; VASCULAR-DISEASE; DYNAMIC EXERCISE; HETEROGENEITY;
   VASOCONSTRICTION; VASODILATION; CIRCULATION
AB Both obesity and metabolic syndrome are important cardiovascular disease risk factors. In this review, we explore the hypothesis that young obese adults and adults with metabolic syndrome exhibit alterations in blood flow regulation that occur before the onset of overt cardiovascular dysfunction.
C1 [Limberg, Jacqueline K.] Mayo Clin, Dept Anesthesiol, 200 1st St SW, Rochester, MN 55905 USA.
   [Limberg, Jacqueline K.; Schrage, William G.] Univ Wisconsin, Dept Kinesiol, Madison, WI USA.
   [Morgan, Barbara J.] Univ Wisconsin, Dept Orthoped & Rehabil, Madison, WI USA.
C3 Mayo Clinic; University of Wisconsin System; University of Wisconsin
   Madison; University of Wisconsin System; University of Wisconsin Madison
RP Limberg, JK (corresponding author), Mayo Clin, Dept Anesthesiol, 200 1st St SW, Rochester, MN 55905 USA.
EM Limberg.Jacqueline@mayo.edu
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NR 43
TC 18
Z9 20
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0091-6331
EI 1538-3008
J9 EXERC SPORT SCI REV
JI Exerc. Sport Sci. Rev.
PD JUL
PY 2016
VL 44
IS 3
BP 116
EP 122
DI 10.1249/JES.0000000000000083
PG 7
WC Physiology; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology; Sport Sciences
GA DO9ED
UT WOS:000378086200006
PM 27223271
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Bozbulut, R
   Döger, E
   Camurdan, MO
   Bideci, A
AF Bozbulut, Rukiye
   Doger, Esra
   Camurdan, Mahmut Orhun
   Bideci, Aysun
TI The Effect of Dietary Acid Load on Cardiometabolic Risk, Psychological
   Resilience and Sleep Quality in Adolescents with Obesity
SO JOURNAL OF CLINICAL RESEARCH IN PEDIATRIC ENDOCRINOLOGY
LA English
DT Article
DE Dietary acid load; cardiometabolic risk; psychological resilience; sleep
   quality
ID BODY-MASS INDEX; INSULIN-RESISTANCE; CHILDREN; WEIGHT; HEIGHT; HEALTH
AB Objective: Mild metabolic acidosis may adversely affect cardiovascular risk factors, and diet-dependent acid-base load may impair mental health and sleep quality. The aim of this study was to investigate the effects of dietary acid load (DAL) on cardiometabolic risk factors, psychological resilience, and sleep quality in adolescents with obesity. Methods: Obese adolescents participated in the study. Biochemical parameters, anthropometric measurements and blood pressures were measured. Three-day retrospective food intake records were collected from the adolescents, and potential renal acid load (PRAL), net endogenous acid production (NEAP), and DAL were derived from food intake records. Psychological resilience was assessed by the Child and Youth Resilience Measure (CYRM-12) and sleep quality was assessed by the Pittsburgh Sleep Quality Index (PSQI). Results: A total of 205 adolescents with obesity (105 males, 100 females) aged 13-18 years participated. Body mass index, fat mass, fat percentage, fasting insulin, triglyceride, systolic blood pressure, homeostasis model assessment for insulin resistance (HOMA-IR) and PSQI scores were significantly higher and psychological resilience levels were significantly lower in high tertiles of DAL (p<0.05). Adolescents in the lowest tertile of DAL scores had higher consumption of whole grains, vegetables, dairy, legumes, and higher intakes of potassium and calcium than adolescents in the highest tertile of the DAL scores (p<0.05). Red meat, and white meat consumption and sodium intake were higher in adolescents in the high tertiles (p<0.05). Energy intakes were found to be significantly lower in the first tertile of PRAL and DAL scores compared to the other tertiles (p<0.05). A linear regression model ahowed an increase in NEAP, PRAL and DAL scores led to a decrease in psychological resilience score and an increase in PSQI and HOMA-IR scores (p<0.05). Conclusion: High DAL was associated with high cardiometabolic risk, insulin resistance, and low psychological resilience and poor sleep quality.
C1 [Bozbulut, Rukiye; Doger, Esra; Camurdan, Mahmut Orhun; Bideci, Aysun] Gazi Univ, Fac Med, Dept Pediat Endocrinol, Ankara, Turkiye.
C3 Gazi University
RP Bozbulut, R (corresponding author), Gazi Univ, Fac Med, Dept Pediat Endocrinol, Ankara, Turkiye.
EM dyt_rukiye@hotmail.com
RI Döğer, Esra/AFE-9507-2022
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NR 44
TC 0
Z9 0
U1 0
U2 0
PU GALENOS PUBL HOUSE
PI ISTANBUL
PA Kacamak Sokak 21/1, ISTANBUL, Findikzade, TURKIYE
SN 1308-5727
EI 1308-5735
J9 J CLIN RES PEDIATR E
JI J. Clin Res. Pediatr. Endocrinol.
PD MAR
PY 2025
VL 17
IS 1
BP 58
EP 67
DI 10.4274/jcrpe.galenos.2024.2024-3-9
PG 10
WC Endocrinology & Metabolism; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Pediatrics
GA 0LI6K
UT WOS:001450105400001
PM 39311554
OA gold
DA 2025-06-11
ER

PT J
AU Bærentzen, SL
   Thomsen, MB
   Alstrup, AKO
   Wegener, G
   Brooks, DJ
   Winterdahl, M
   Landau, AM
AF Baerentzen, Simone Larsen
   Thomsen, Majken Borup
   Alstrup, Aage K. O.
   Wegener, Gregers
   Brooks, David J.
   Winterdahl, Michael
   Landau, Anne M.
TI Excessive sucrose consumption reduces synaptic density and increases
   cannabinoid receptors in Gottingen minipigs
SO NEUROPHARMACOLOGY
LA English
DT Article
DE Sucrose; Minipig; Autoradiography; Synaptic vesicle glycoprotein 2A;
   mGluR5; CB1
ID SUGAR-SWEETENED BEVERAGES; DIET-INDUCED OBESITY; MENTAL-HEALTH;
   ENERGY-INTAKE; DOPAMINE; DEPRESSION; WEIGHT; AVAILABILITY; METAANALYSIS;
   RIMONABANT
AB Diets high in sucrose and fat are becoming more prevalent the world over, accompanied by a raised prevalence of cardiovascular diseases, cancers, diabetes, obesity, and metabolic syndrome. Clinical studies link unhealthy diets with the development of mental health disorders, particularly depression. Here, we investigate the effects of 12 days of sucrose consumption administered as 2 L of 25% sucrose solution daily for 12 days in Go <spacing diaeresis>ttingen minipigs on the function of brain receptors involved in reward and motivation, regulating feeding, and pre- and postsynaptic mechanisms. Through quantitative autoradiography of cryostat sections containing limbic brain regions, we investigated the effects of sucrose restricted to a 1-h period each morning, on the specific binding of [ 3 H]raclopride on dopamine D2/3 receptors, [ 3 H]UCB-J at synaptic vesicle glycoprotein 2A (SV2A), [ 3 H]MPEP gamma at metabotropic glutamate receptor subtype 5 (mGluR5) and [ 3 H]SR141716A at the cannabinoid receptor 1 (CB1). Compared to control diet animals, the sucrose group showed significantly lower [ 3 H]UCB-J and [ 3 H] MPEP gamma binding in the prefrontal cortex. The sucrose -consuming minipigs showed higher hippocampal CB1 binding, but unaltered dopamine D2/3 binding compared to the control group. We found that the sucrose diet reduced the synaptic density marker while increasing CB1 binding in limbic brain structures, which may subserve maladaptive changes in appetite regulation and feeding. Further studies of the effects of diets and lifestyle habits on brain neuroreceptor and synaptic density markers are warranted.
C1 [Baerentzen, Simone Larsen; Thomsen, Majken Borup; Wegener, Gregers; Winterdahl, Michael; Landau, Anne M.] Aarhus Univ, Dept Clin Med, Translat Neuropsychiat Unit, Palle Juul Jensens Blvd 11,A701, DK-8200 Aarhus N, Denmark.
   [Alstrup, Aage K. O.; Brooks, David J.] Aarhus Univ Hosp, Dept Nucl Med, Aarhus, Denmark.
   [Alstrup, Aage K. O.; Brooks, David J.] Aarhus Univ Hosp, PET Ctr, Aarhus, Denmark.
   [Brooks, David J.] Newcastle Univ, Inst Translat & Clin Res, Newcastle Upon Tyne, England.
C3 Aarhus University; Aarhus University; Aarhus University; Newcastle
   University - UK
RP Landau, AM (corresponding author), Aarhus Univ, Dept Clin Med, Translat Neuropsychiat Unit, Palle Juul Jensens Blvd 11,A701, DK-8200 Aarhus N, Denmark.
EM alandau@clin.au.dk
RI Winterdahl, Michael/AAG-2887-2019; Landau, Anne/AAG-2797-2019; Brooks,
   David/AFM-5666-2022; Winterdahl, Michael/Q-9817-2016; Wegener,
   Gregers/A-1019-2011
OI Brooks, David/0000-0003-2602-2518; Baerentzen, Simone
   Larsen/0000-0003-1935-3650; Winterdahl, Michael/0000-0002-8790-7574;
   Wegener, Gregers/0000-0002-0081-0068; Landau, Anne
   M/0000-0002-7371-8713; Alstrup, Aage Kristian Olsen/0000-0002-0084-9122
FU Aarhus University Research Foundation (AUFF); Riisfort Fonden; Aarhus
   University Health
FX The study was funded by grants from the Aarhus University Research
   Foundation (AUFF) and Riisfort Fonden to AML. An Aarhus University
   Health recruitment fellowship funded salary for PhD student SLB. The
   funding sources were not involved in the study design, analysis, data
   interpretation, manuscript writing, or the decision to submit the
   manuscript for publication.
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NR 46
TC 2
Z9 2
U1 0
U2 0
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0028-3908
EI 1873-7064
J9 NEUROPHARMACOLOGY
JI Neuropharmacology
PD SEP 15
PY 2024
VL 256
AR 110018
DI 10.1016/j.neuropharm.2024.110018
EA JUN 2024
PG 8
WC Neurosciences; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pharmacology & Pharmacy
GA UX7Q9
UT WOS:001251433600001
PM 38810925
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Shokeen, D
   Sokal-Gutierrez, K
AF Shokeen, Deepa
   Sokal-Gutierrez, Karen
TI Association between cardio-metabolic risks and depressive symptoms among
   US adults (NHANES 2013-2018)
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Depression; Stress; Anxiety; Cardiometabolic risk; Overweight/obesity
ID CORONARY HEART-DISEASE; QUALITY-OF-LIFE; CARDIOVASCULAR HEALTH;
   MORTALITY; PREVALENCE; MANAGEMENT; SEVERITY; DISORDER; PROGRAM; WOMEN
AB Objectives: To elucidate the association between cardio-metabolic risk factors and depressive symptoms among US adults.
   Methods: Data on 9,477 adults >= age 18 from the US National Health and Nutrition Examination Survey (NHANES) 2013-2018 were used. Number of cardio-metabolic risk (CMR) factors, from 0 to 5, was based on BMI, blood pressure, fasting blood glucose, and lipid levels. Depressive symptoms by Patient Health Question-naire (PHQ-9) scores were categorized "no to mild symptoms" (0-9) and "clinically-significant depressive (CSD) symptoms" (10-27). Logistic regression analysis tested associations between CMR factors and CSD symptoms, adjusted for age, gender, education, income, race/ethnicity and smoking status.
   Results: CSD symptoms were significantly associated with low HDL, abdominal obesity, and high triglycerides. Increased numbers of CMR factors were associated with increased odds of CSD symptoms, from 1.45 times for 1 CMR to 2.55 times for 5 CMRs. The cross-sectional nature of the present study has resulted in some limitations like the inability to determine the direction and causality of the effects between depression and CMR. The study data was subject to response bias and recall errors as the participants self-reported the use of medications.
   Conclusions: In US adults, cardio-metabolic risk factors were associated with clinically-significant depressive symptoms. Public health and clinical programs should include screening for both health issues, intervention for modifiable risk factors, and support for social determinants of health.
C1 [Shokeen, Deepa; Sokal-Gutierrez, Karen] Univ Calif Berkeley, Sch Publ Hlth, Berkeley, CA 94720 USA.
C3 University of California System; University of California Berkeley
RP Shokeen, D (corresponding author), Univ Calif Berkeley, Sch Publ Hlth, Berkeley, CA 94720 USA.
EM deepa_shokeen@berkeley.edu
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NR 38
TC 8
Z9 8
U1 0
U2 9
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD FEB 15
PY 2022
VL 299
BP 166
EP 173
DI 10.1016/j.jad.2021.11.065
EA DEC 2021
PG 8
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA XY6BD
UT WOS:000737054400022
PM 34856304
DA 2025-06-11
ER

PT J
AU Fond, GB
   Yon, DK
   Tran, B
   Mallet, J
   Urbach, M
   Leignier, S
   Rey, R
   Misdrahi, D
   Llorca, PM
   Schuerhoff, F
   Berna, F
   Boyer, L
AF Fond, Guillaume B.
   Yon, Dong Keon
   Tran, Bach
   Mallet, Jasmina
   Urbach, Mathieu
   Leignier, Sylvain
   Rey, Romain
   Misdrahi, David
   Llorca, Pierre-Michel
   Schuerhoff, Franck
   Berna, Fabrice
   Boyer, Laurent
TI Poverty and inequality in real-world schizophrenia: a national study
SO FRONTIERS IN PUBLIC HEALTH
LA English
DT Article
DE schizophrenia; psychotic disorders; mental health; poverty; inequality;
   public health; psychiatry; quality of life
ID SOCIOECONOMIC-STATUS; METABOLIC SYNDROME; ASSOCIATION; RELIABILITY;
   SCALE; INDIVIDUALS; DEPRESSION; VALIDITY; INSIGHT
AB BackgroundSchizophrenia has high socioeconomic impact among severe psychiatric disorders.AimsTo explore clinician-reported and patient-reported inequities between patients under the poverty threshold vs. the others.Method916 patients consecutively recruited in 10 national centers received a comprehensive standardized evaluation of illness severity, addictions and patient-reported outcomes.Results739 (80.7%) of the patients were classified in the poverty group. This group had poorer objective illness outcomes (lower positive, negative, cognitive, excitement/aggressive and self-neglect symptoms and lifetime history of planned suicide) in multivariate analyses. While they had similar access to treatments and psychotherapy, they had lower access to socially useful activities, couple's life, housing and parenthood. They had also more disturbed metabolic parameters. On the contrary, the poverty group reported better self-esteem. No significant difference for depression, risky health behavior including addictions and sedentary behavior was found.InterpretationThe equity in access to care is attributed to the French social system. However, mental and physical health remain poorer in these patients, and they still experience poor access to social roles independently of illness severity and despite healthcare interventions. These patients may have paradoxically better self-esteem due to decreased contact with society and therefore lower stigma exposure (especially at work). Schizophrenia presents itself as a distinct impoverished population concerning health-related outcomes and social integration, warranting focus in public health initiatives and improved treatment, including tailored interventions, collaborative care models, accessible mental health services, housing support, vocational training and employment support, community integration, education and awareness, research and data collection, culturally competent approaches, and long-term support.
C1 [Fond, Guillaume B.; Mallet, Jasmina; Urbach, Mathieu; Leignier, Sylvain; Rey, Romain; Misdrahi, David; Llorca, Pierre-Michel; Schuerhoff, Franck; Berna, Fabrice; Boyer, Laurent] Fdn FondaMental, Creteil, France.
   [Fond, Guillaume B.; Tran, Bach; Boyer, Laurent] Aix Marseille Univ, Fac Medecine Sect Timone, AP HM, EA 3279, Marseille, France.
   [Fond, Guillaume B.; Tran, Bach; Boyer, Laurent] CEReSS Ctr Etud, Rech Serv St & Qual vie, Marseille, France.
   [Yon, Dong Keon] Kyung Hee Univ, Coll Med, Dept Pediat, Seoul, South Korea.
   [Yon, Dong Keon] Kyung Hee Univ, Med Sci Res Inst, Ctr Digital Hlth, Coll Med, Seoul, South Korea.
   [Tran, Bach] Aix Marseille Univ, Res Ctr Hlth Serv & Qual Life, Marseille, France.
   [Mallet, Jasmina] Univ Paris, Louis Mourier Hosp, AP HP, DMU ESPRIT,GHU,Dept Psychiat, Paris, France.
   [Urbach, Mathieu] Ctr Hosp Versailles, Serv Univ Psychiat Adultes & Addictol, Le Chesnay, France.
   [Leignier, Sylvain] CH Alpes Isere, Ctr Referent Rehabil Psychosociale & Remediat Cog, Grenoble, France.
   [Rey, Romain] Univ Claude Bernard Lyon 1, Ctr Rech Neurosci Lyon CRNL UMR5292, CNRS, INSERM U1028, F-69500 Bron, France.
   [Misdrahi, David] Univ Bordeaux, Ctr Hosp Charles Perrens, Pole Psychiat Gen & Univ, France NutriNeuro,INRAE UMR 1286, F-33076 Bordeaux, France.
   [Misdrahi, David] INCIA, CNRS, UMR 5287, Bordeaux, France.
   [Llorca, Pierre-Michel] Univ Clermont Auvergne, Inst Pascal, CMP B,CHU, CNRS, F-63000 Clermont Ferrand, France.
   [Schuerhoff, Franck] Univ Paris Est Creteil UPEC, Hop Univ H Mondor, AP HP,Fdn FondaMental, DMU IMPACT,IMRB Translat Neuropsychiat, F-94010 Creteil, France.
   [Berna, Fabrice] Univ Strasbourg, Federat Med Translat Strasbourg FMTS, Strasbourg, France.
C3 Aix-Marseille Universite; Assistance Publique-Hopitaux de Marseille;
   Kyung Hee University; Kyung Hee University; Aix-Marseille Universite;
   Universite Paris Cite; Assistance Publique Hopitaux Paris (APHP);
   Hopital Universitaire Louis-Mourier - APHP; Centre Hospitalier de
   Versailles; Universite Paris Saclay; Centre National de la Recherche
   Scientifique (CNRS); Institut National de la Sante et de la Recherche
   Medicale (Inserm); Universite Claude Bernard Lyon 1; Universite Jean
   Monnet; INRAE; Universite de Bordeaux; Universite de Bordeaux; Centre
   National de la Recherche Scientifique (CNRS); CNRS - National Institute
   for Biology (INSB); Centre National de la Recherche Scientifique (CNRS);
   Universite Clermont Auvergne (UCA); CHU Clermont Ferrand; Assistance
   Publique Hopitaux Paris (APHP); Universite
   Paris-Est-Creteil-Val-de-Marne (UPEC); Hopital Universitaire
   Henri-Mondor - APHP; Universites de Strasbourg Etablissements Associes;
   Universite de Strasbourg
RP Fond, GB (corresponding author), Fdn FondaMental, Creteil, France.; Fond, GB (corresponding author), Aix Marseille Univ, Fac Medecine Sect Timone, AP HM, EA 3279, Marseille, France.; Fond, GB (corresponding author), CEReSS Ctr Etud, Rech Serv St & Qual vie, Marseille, France.
EM guillaume.fond@ap-hm.fr
RI Berna, Fabrice/J-2701-2019; Fond, Guillaume/D-7646-2011; Yon, Dong
   Keon/M-1264-2017; Mallet, Jasmina/GNP-7160-2022; Boyer,
   Laurent/E-5728-2016
OI Boyer, Laurent/0000-0003-1229-6622; Yon, Dong Keon/0000-0003-1628-9948
FU Hopitaux Universitaires de Marseille (AP-HM)
FX This work was funded by Hopitaux Universitaires de Marseille (AP-HM).
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NR 42
TC 9
Z9 9
U1 1
U2 4
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 2296-2565
J9 FRONT PUBLIC HEALTH
JI Front. Public Health
PD OCT 31
PY 2023
VL 11
AR 1182441
DI 10.3389/fpubh.2023.1182441
PG 9
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA X8ZI1
UT WOS:001101265700001
PM 38026279
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Voeghtly, LM
   Neatrour, DM
   Decewicz, DJ
   Burke, A
   Haberkorn, MJ
   Lechak, F
   Patney, HL
   Vernalis, MN
   Ellsworth, DL
AF Voeghtly, L. M.
   Neatrour, D. M.
   Decewicz, D. J.
   Burke, A.
   Haberkorn, M. J.
   Lechak, F.
   Patney, H. L.
   Vernalis, M. N.
   Ellsworth, D. L.
TI Cardiometabolic risk reduction in an intensive cardiovascular health
   program
SO NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
LA English
DT Article
DE Cardiovascular disease; Cardiometabolic risk; Insulin; Leptin; Risk
   reduction; Lifestyle modification; Low-fat diet; Exercise
ID PHYSICAL-ACTIVITY; SEX-DIFFERENCES; LEPTIN; DISEASE; PREVENTION;
   OBESITY; INSULIN; ADULTS
AB Background and aims: Insulin and leptin are important markers of insulin resistance and vascular inflammation in metabolic and cardiovascular diseases. This study evaluated changes in circulating levels of insulin and leptin during a cardiovascular health program to improve our understanding of cardiometabolic risk reduction.
   Methods and results: Participants (n = 76) completed a prospective, nonrandomized program designed to stabilize or reverse progression of coronary artery disease through dietary changes, exercise, stress management, and group support. Controls (n = 76) were matched to participants based on age, gender, and disease status. Traditional cardiovascular risk factors were assessed at baseline, 12 weeks, and 52 weeks by standard methods. Dietary data were collected by 72-h recall and evaluated by Food Processor (R) v8.4.0. Ultrasensitive insulin and leptin levels were measured by radioimmunoassay. Participants successfully reduced their total caloric intake from >2000 calories per day to similar to 1700 calories per day (p < 0.05 compared to controls), lowered daily fat intake by > 60% (p < 0.001 compared to controls), and increased carbohydrate intake by > 30% (p < 0.001). Repeated-measures ANOVA indicated significant beneficial changes (p < 0.001 compared to controls) in plasma insulin (-19%) and leptin (-33%) during the lifestyle program, as well as improvement in traditional cardiovascular risk factors. Response was similar between men and women for most risk factors and was not markedly influenced by medication use.
   Conclusion: Lifestyle changes focusing on diet, physical activity, and stress reduction can successfully modify both cardiovascular and metabolic risk factors, with the potential to mediate cardiometabolic risk through beneficial anti-inflammatory and anti-oxidative effects on the vasculature. (C) 2012 Elsevier B.V. All rights reserved.
C1 [Voeghtly, L. M.; Decewicz, D. J.; Patney, H. L.; Ellsworth, D. L.] Windber Res Inst, Integrat Cardiac Hlth Program, Windber, PA USA.
   [Neatrour, D. M.; Burke, A.; Haberkorn, M. J.; Lechak, F.] Windber Med Ctr, Windber, PA USA.
   [Vernalis, M. N.] Walter Reed Natl Mil Med Ctr, Integrat Cardiac Hlth Program, Bethesda, MD USA.
C3 Windber Research Institute; Walter Reed National Military Medical Center
RP Ellsworth, DL (corresponding author), Windber Res Inst, Integrat Cardiac Hlth Program, Windber, PA USA.
EM d.ellsworth@wriwindber.org
FU United States Army Medical Research and Materiel Command
   (MRMC)/Telemedicine and Advanced Technology Research Center (TATRC),
   Fort Detrick, Maryland; Henry M. Jackson Foundation for the Advancement
   of Military Medicine, Rockville, Maryland; Clinical Research Unit
   Program of the National Center of Research Resources, National
   Institutes of Health [M01RR-02719]
FX Supported by the United States Army Medical Research and Materiel
   Command (MRMC)/Telemedicine and Advanced Technology Research Center
   (TATRC), Fort Detrick, Maryland, the Henry M. Jackson Foundation for the
   Advancement of Military Medicine, Rockville, Maryland, and grant
   M01RR-02719 from the Clinical Research Unit Program of the National
   Center of Research Resources, National Institutes of Health.
CR Beltowski J, 2006, ATHEROSCLEROSIS, V189, P47, DOI 10.1016/j.atherosclerosis.2006.03.003
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NR 29
TC 12
Z9 13
U1 0
U2 10
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0939-4753
EI 1590-3729
J9 NUTR METAB CARDIOVAS
JI Nutr. Metab. Carbiovasc. Dis.
PD JUL
PY 2013
VL 23
IS 7
BP 662
EP 669
DI 10.1016/j.numecd.2012.01.012
PG 8
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism; Nutrition
   & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism;
   Nutrition & Dietetics
GA 167QF
UT WOS:000320646100011
PM 22633795
DA 2025-06-11
ER

PT J
AU Grunwald, T
   Fadia, S
   Bernstein, B
   Naliborski, M
   Wu, SF
   De Luca, F
AF Grunwald, Tal
   Fadia, Shruti
   Bernstein, Bruce
   Naliborski, Matthew
   Wu, Shufang
   De Luca, Francesco
TI Vitamin D supplementation, the metabolic syndrome and oxidative stress
   in obese children
SO JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
LA English
DT Article
DE metabolism; obesity; vitamin D
ID CARDIOMETABOLIC RISK-FACTORS; BETA-CELL FUNCTION; INSULIN-RESISTANCE;
   25-HYDROXYVITAMIN D; D DEFICIENCY; D INSUFFICIENCY; HYDROGEN-PEROXIDE;
   ADOLESCENTS; GLUCOSE; ASSOCIATION
AB Background: Previous studies suggest that vitamin D may play a role in cardiovascular and metabolic health. Oxidative stress has also been implicated in the development of cardiovascular disease. Evidence suggests that vitamin D deficiency may contribute to the occurrence of oxidative stress. This study aimed to determine whether treatment and correction of vitamin D deficiency in obese children led to changes in their metabolic profile, independent of changes in adiposity. In addition, we aimed to determine whether vitamin D deficiency and oxidative stress are causally related in obese children.
   Methods: In the retrospective arm, chart review identified 32 obese children who experienced normalization of vitamin D deficiency or insufficiency with vitamin D supplementation. We then correlated laboratory and anthropometric data with vitamin D levels. In the prospective arm of the study, urinary 8-isoprostane and hydrogen peroxide were measured before and after correction of vitamin D deficiency/insufficiency and correlated to vitamin D levels in seven patients.
   Results: In our predominantly Hispanic population of obese children in an urban setting, we demonstrated a cause-effect relationship between vitamin D deficiency and oxidative stress. In contrast, we found no association between vitamin D status, adiposity, and markers of insulin sensitivity, nor any effect of vitamin D treatment on the same parameters.
   Conclusions: These discordant findings suggest a differential effect of vitamin D on cardiovascular risk factors such as oxidative stress and insulin resistance. To confirm these findings, further prospective studies with larger sample size and longer follow-up are warranted.
C1 [De Luca, Francesco] St Christophers Hosp Children, Sect Endocrinol & Diabet, Dept Pediat, 160 East Erie Ave, Philadelphia, PA 19134 USA.
   [Grunwald, Tal; Fadia, Shruti; Naliborski, Matthew; Wu, Shufang] Drexel Univ, Coll Med, St Christophers Hosp Children, Dept Pediat,Sect Endocrinol & Diabet, Philadelphia, PA 19104 USA.
   [Fadia, Shruti] Mem Childrens Hosp, South Bend, IN USA.
   [Bernstein, Bruce] Drexel Univ, Coll Med, St Christophers Hosp Children, Dept Pediat,Sect Gen Pediat, Philadelphia, PA 19104 USA.
   [Wu, Shufang] Xi An Jiao Tong Univ, Sch Med, Affiliated Hosp 1, Ctr Translat Med, Xian, Shaanxi, Peoples R China.
C3 Drexel University; Drexel University; Xi'an Jiaotong University
RP De Luca, F (corresponding author), St Christophers Hosp Children, Sect Endocrinol & Diabet, Dept Pediat, 160 East Erie Ave, Philadelphia, PA 19134 USA.
EM Francesco.deluca@drexelmed.edu
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NR 37
TC 13
Z9 13
U1 0
U2 16
PU WALTER DE GRUYTER GMBH
PI BERLIN
PA GENTHINER STRASSE 13, D-10785 BERLIN, GERMANY
SN 0334-018X
EI 2191-0251
J9 J PEDIATR ENDOCR MET
JI J. Pediatr. Endocrinol. Metab.
PD APR
PY 2017
VL 30
IS 4
BP 383
EP 388
DI 10.1515/jpem-2016-0211
PG 6
WC Endocrinology & Metabolism; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Pediatrics
GA ET7FQ
UT WOS:000400460100003
PM 27977406
DA 2025-06-11
ER

PT J
AU Chen, JZ
   Huang, Y
   Li, XL
AF Chen, Junzhi
   Huang, Yan
   Li, Xiaolin
TI The association between lymphocyte to high-density lipoprotein ratio and
   depression: Data from NHANES 2015-2018
SO BRAIN AND BEHAVIOR
LA English
DT Article
DE depression; immune dysfunction; inflammation; lymphocyte to high-density
   lipoprotein ratio
ID METABOLIC SYNDROME; INSULIN-RESISTANCE; MAJOR DEPRESSION; INFLAMMATION;
   METAANALYSIS; HEALTH; RISK; POPULATION; MORTALITY; INDICATOR
AB Introduction: The relationship of lymphocyte to high-density lipoprotein ratio (LHR) with depression remains uncertain. We aimed to evaluate the association between LHR and depression in US adults. Methods: In this cross-sectional study, a total of 4216 participants were enrolled from the National Health and Nutrition Examination Survey (2015-2018). Depressive symptoms were measured with the Patient Health Questionnaire-9 (PHQ-9). Participants were classified as having depression if PHQ-9 scores were <= 10. Multiple logistic regression models were used to explore the relationship between the LHR and depression. Results: Overall, the LHR was significantly associated with depression (per standard deviation increment; adjusted odds ratio (OR), 1.31; 95% confidence interval (CI) [1.14, 1.50]) after adjusted potential variables. Interactions between LHR with metabolic syndrome (MetS) and body mass index (BMI) on the risk of depression were found in stratified analysis (p for interaction < .05). Conclusions: A higher level of LHR was significantly associated with higher odds of having depression in US adults, and it was strengthened in participants with MetS or BMI ranging from 25 to 30 kg/m(2).
C1 [Chen, Junzhi; Li, Xiaolin] Shenzhen Univ, South China Hosp, Div Nephrol, Shenzhen, Peoples R China.
   [Huang, Yan] Southern Med Univ, Nanfang Hosp, Natl Clin Res Ctr Kidney Dis, State Key Lab Organ Failure Res, Guangzhou, Peoples R China.
C3 Shenzhen University; Southern Medical University - China
RP Chen, JZ (corresponding author), Shenzhen Univ, South China Hosp, Div Nephrol, Shenzhen, Peoples R China.
EM junzhichen2016@163.com
RI Li, Xiaolin/C-2836-2013
FU This research did not receive any specific grant from funding agencies
   in the public, commercial, or not-for-profit sectors.
FX We thank all the participants in this study.
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NR 60
TC 4
Z9 4
U1 5
U2 8
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 2162-3279
J9 BRAIN BEHAV
JI Brain Behav.
PD MAR
PY 2024
VL 14
IS 3
AR e3467
DI 10.1002/brb3.3467
PG 11
WC Behavioral Sciences; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Behavioral Sciences; Neurosciences & Neurology
GA KT8W1
UT WOS:001182317400001
PM 38468463
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Chang, HC
   Hsu, YH
   Chou, MY
   Chu, CS
   Su, CS
   Liang, CK
   Chang, CH
   Yang, T
   Chen, LK
   Lin, YT
AF Chang, Hui-Chi
   Hsu, Ying-Hsin
   Chou, Ming-Yueh
   Chu, Che-sheng
   Su, Chen-San
   Liang, Chih-Kuang
   Chang, Cheng-Ho
   Yang, Tsan
   Chen, Liang-Kung
   Lin, Yu-Te
TI Insomnia in older adult females is highly associated with metabolic
   syndrome
SO EUROPEAN GERIATRIC MEDICINE
LA English
DT Article
DE Insomnia; Metabolic syndrome; Sleep disturbance; Older adults; Gender
ID OBSTRUCTIVE SLEEP-APNEA; POSTMENOPAUSAL WOMEN; POPULATION; DURATION;
   PREVALENCE; HEALTH; RISK; DISTURBANCES; VALIDATION; DISEASE
AB Purpose The aim of this study is to investigate the relationships between insomnia and metabolic syndrome among Taiwanese older adults. Methods This cross-sectional study enrolled participants aged over 60 years from outpatient clinics between July and September 2018. Demographic characteristics of all participants and questionnaire data for sleep duration, use of hypnotic agents, baseline activities of daily living, 5 items of the geriatric depression scale, comorbidities, medications, and risk of obstructive sleep apnea were obtained. Insomnia was defined by scores of questionnaires of the Chinese version of the Athens Insomnia Scale higher or equal to 6 points. Metabolic syndrome was diagnosed according to criteria of the National Cholesterol Education Program Adult Treatment Panel III. Multivariable forward stepwise logistic regression analysis was applied to investigate independent associations between insomnia and metabolic syndrome before and after stratifying by gender. Results Among the 336 participants (mean age 74.9 +/- 8.5 years, female 49.1%), 63.1% participants had metabolic syndrome, with significantly higher prevalence among females than males (males 56.7%; females 69.7%). Participants with metabolic syndrome had higher rates of insomnia (34.0% vs. 21.8%, P = 0.018). The significant associations between insomnia and metabolic syndrome disappeared after adjusting for all covariates. However, insomnia was independently associated with metabolic syndrome in older females (adjusted OR 2.614, 95% CI 1.011-6.763, P = 0.048) after adjusting for all covariates. Conclusions Insomnia is significantly associated with metabolic syndrome among older female adults. These findings suggest that gender may play a role in the pathogenesis of insomnia and metabolic syndrome in older adults.
   Key summary pointsAim To investigate the relationships between insomnia and metabolic syndrome among Taiwanese older adults. Findings Participants with metabolic syndrome had higher rates of insomnia. The significant associations between insomnia and metabolic syndrome disappeared after adjusting for all covariates. However, insomnia was independently associated with metabolic syndrome in older females after adjusting for all covariates. Message Older adult participants with metabolic syndrome have higher prevalence of insomnia. Insomnia has higher independent odds for metabolic syndrome in older females, but not in older males.
C1 [Chang, Hui-Chi; Hsu, Ying-Hsin; Su, Chen-San; Liang, Chih-Kuang; Lin, Yu-Te] Kaohsiung Vet Gen Hosp, Div Neurol, Dept Internal Med, Kaohsiung, Taiwan.
   [Chang, Hui-Chi; Hsu, Ying-Hsin; Chou, Ming-Yueh; Chu, Che-sheng; Liang, Chih-Kuang; Lin, Yu-Te] Kaohsiung Vet Gen Hosp, Ctr Geriatr & Gerontol, Kaohsiung, Taiwan.
   [Hsu, Ying-Hsin] Chia Nan Univ Pharm & Sci, Tainan, Taiwan.
   [Chou, Ming-Yueh; Liang, Chih-Kuang; Chen, Liang-Kung] Natl Yang Ming Chiao Tung Univ, Aging & Hlth Res Ctr, Yangming Campus, Taipei, Taiwan.
   [Chou, Ming-Yueh; Liang, Chih-Kuang; Chen, Liang-Kung] Natl Yang Ming Chiao Tung Univ, Sch Med, Dept Geriatr Med, Yangming Campus, Taipei, Taiwan.
   [Chu, Che-sheng; Chang, Cheng-Ho] Kaohsiung Vet Gen Hosp, Dept Psychiat, Kaohsiung, Taiwan.
   [Yang, Tsan] Meiho Univ, Dept Hlth Business Adm, Pingtung, Taiwan.
   [Chen, Liang-Kung] Taipei Vet Gen Hosp, Ctr Geriatr & Gerontol, Taipei, Taiwan.
   [Chen, Liang-Kung] Taipei Municipal Gan Dau Hosp, Taipei, Taiwan.
   [Lin, Yu-Te] Tajen Univ, Dept Pharm, Pingtung, Taiwan.
C3 Kaohsiung Veterans General Hospital; Kaohsiung Veterans General
   Hospital; Chia Nan University of Pharmacy & Science; National Yang Ming
   Chiao Tung University; National Yang Ming Chiao Tung University;
   Kaohsiung Veterans General Hospital; Taipei Veterans General Hospital
RP Liang, CK (corresponding author), Kaohsiung Vet Gen Hosp, Div Neurol, Dept Internal Med, Kaohsiung, Taiwan.; Liang, CK (corresponding author), Kaohsiung Vet Gen Hosp, Ctr Geriatr & Gerontol, Kaohsiung, Taiwan.; Liang, CK (corresponding author), Natl Yang Ming Chiao Tung Univ, Aging & Hlth Res Ctr, Yangming Campus, Taipei, Taiwan.; Liang, CK (corresponding author), Natl Yang Ming Chiao Tung Univ, Sch Med, Dept Geriatr Med, Yangming Campus, Taipei, Taiwan.
EM ck.vghks@gmail.com
RI Liang, Chih-Kuang/AAJ-5235-2020; lin, yt/IQT-6771-2023; Peng,
   Cheng-Yuan/JVD-9064-2023; Chen, Liang-Kung/JBI-8802-2023
OI Liang, Chih-Kuang/0000-0003-1604-1600
FU Kaohsiung Veterans General Hospital [VGHKS18-CT6-15]
FX This study was sponsored by the Kaohsiung Veterans General Hospital
   [Grant number VGHKS18-CT6-15]. The funding organizations had no role in
   the design, methods, participant recruitment, data collection, analysis,
   or preparation of the article.
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NR 50
TC 2
Z9 2
U1 2
U2 10
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1878-7649
EI 1878-7657
J9 EUR GERIATR MED
JI Eur. Geriatr. Med.
PD FEB
PY 2022
VL 13
IS 1
BP 203
EP 212
DI 10.1007/s41999-021-00543-y
EA JUL 2021
PG 10
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA ZE3YL
UT WOS:000675293200001
PM 34291420
DA 2025-06-11
ER

PT J
AU Hruska, B
   Pressman, SD
   Bendinskas, K
   Gump, BB
AF Hruska, Bryce
   Pressman, Sarah D.
   Bendinskas, Kestutis
   Gump, Brooks B.
TI Vacation frequency is associated with metabolic syndrome and symptoms
SO PSYCHOLOGY & HEALTH
LA English
DT Article
DE Vacation; paid time off; physical health; recovery experience; metabolic
   syndrome; metabolic symptoms
ID JOB STRAIN; PSYCHOSOCIAL PREDICTORS; BLOOD-PRESSURE; FOLLOW-UP; HEALTH;
   STRESS; RISK; PREVALENCE; MORTALITY; EXPOSURE
AB Objective: To examine the extent to which vacationing behavior is associated with metabolic outcomes. Specifically, we consider how total vacation episodes and total vacation days from the past 12 months relate to metabolic syndrome and metabolic symptoms. Design: Sixty-three workers eligible for paid vacation attended a lab visit during which their blood was drawn and they completed an interview assessing vacationing behavior in the past 12 months. Main outcome measures: Metabolic syndrome and metabolic symptoms are the main outcome measures. Results: Over the past 12 months, participants took approximately five vacations (M = 5.44, SD = 3.16) and used about 2 weeks of their paid vacation days (M = 13.80, SD = 7.25). Participants rated vacations positively, expressing low levels of travel-, childcare- and financial burden-related stress. As vacation episodes increased, metabolic syndrome incidence (OR = 0.76, p = 0.051) and number of metabolic symptoms met (IRR = 0.92, p = 0.035) decreased. Notably, risk for metabolic syndrome decreased by nearly a quarter with each additional vacation taken by participants. Conclusions: Overall, vacations are experienced as positive events. This positive subjective experience may translate into physical health benefits given that vacation frequency may protect against metabolic syndrome and symptoms.
C1 [Hruska, Bryce; Gump, Brooks B.] Syracuse Univ, Dept Publ Hlth, David B Falk Coll Sport & Human Dynam, 444 White Hall, Syracuse, NY 13244 USA.
   [Pressman, Sarah D.] Univ Calif Irvine, Sch Social Ecol, Irvine, CA USA.
   [Bendinskas, Kestutis] SUNY Coll Oswego, Dept Chem, Oswego, NY 13126 USA.
C3 Syracuse University; University of California System; University of
   California Irvine; State University of New York (SUNY) System; State
   University of New York (SUNY) - Oswego
RP Hruska, B (corresponding author), Syracuse Univ, Dept Publ Hlth, David B Falk Coll Sport & Human Dynam, 444 White Hall, Syracuse, NY 13244 USA.
EM bjhruska@syr.edu
RI Gump, Brooks/AFN-3343-2022; Hruska, Bryce/AAO-8780-2020
OI Hruska, Bryce/0000-0002-8651-5827; Gump, Brooks/0000-0001-5906-6651;
   Bendinskas, Kestutis/0000-0002-0275-520X
FU Project: Time Off [28570]
FX This work was supported by Project: Time Off under funding agreement
   28570.
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NR 42
TC 12
Z9 14
U1 0
U2 13
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0887-0446
EI 1476-8321
J9 PSYCHOL HEALTH
JI Psychol. Health
PD JAN 2
PY 2020
VL 35
IS 1
BP 1
EP 15
DI 10.1080/08870446.2019.1628962
EA JUN 2019
PG 15
WC Public, Environmental & Occupational Health; Psychology,
   Multidisciplinary
WE Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; Psychology
GA JZ5VP
UT WOS:000475270700001
PM 31204484
DA 2025-06-11
ER

PT J
AU Zhang, WJ
   Sun, QM
   Chen, BX
   Basta, M
   Xu, CT
   Li, Y
AF Zhang, Wenjuan
   Sun, Qimeng
   Chen, Baixin
   Basta, Maria
   Xu, Chongtao
   Li, Yun
TI Insomnia symptoms are associated with metabolic syndrome in patients
   with severe psychiatric disorders
SO SLEEP MEDICINE
LA English
DT Article
DE Insomnia symptoms; Metabolic syndrome; Insulin resistance; Severe
   psychiatric disorders
ID MAJOR DEPRESSIVE DISORDER; SHORT-SLEEP DURATION; INSULIN-RESISTANCE;
   BIPOLAR DISORDER; MENTAL-DISORDERS; HEART-DISEASE; RATING-SCALE;
   INFLAMMATION; QUALITY; SCHIZOPHRENIA
AB Objective: To examine the relationship between insomnia symptoms and metabolic syndrome in patients with severe psychiatric disorders.
   Methods: We conducted a cross-sectional study including 272 inpatients (mean age: 34.06 +/- 11.52 years, 67.3% males) with severe psychiatric disorders consecutively admitted in Shantou University Mental Health Center Inpatient Department. All patients underwent a psychiatric evaluation. Insomnia symptoms were assessed by the Pittsburgh Sleep Quality Index (PSQI) and defined present if PSQI>7. The diagnosis of metabolic syndrome was defined using the new International Diabetes Federation definition based on clinical and laboratory evaluation.
   Results: Among the 272 patients, 94 (34.6%) presented insomnia symptoms. Overall, patients with insomnia symptoms had significantly higher percentage of metabolic syndrome (23.4% vs. 12.4%, p = 0.019) and hypertriglyceridemia (30.9% vs. 19.1%, p = 0.029), and marginally significantly higher levels of fasting insulin (58.75 +/- 37.22 pmol/L vs. 51.72 +/- 34.09 pmol/L, p = 0.050), homeostasis model assessment of insulin resistance (1.83 +/- 1.31 vs. 1.62 +/- 1.25, p = 0.055) and percentage of insulin resistance (55.3% vs. 44.4%, p = 0.086) compared to those without insomnia symptoms. Multiple logistic regressions showed that patients with insomnia symptoms had significantly higher odds for metabolic syndrome [odds ratio (OR) = 2.99, 95% confidence interval (CI) = 1.25-7.14], central obesity (OR = 3.02, 95% CI = 1.18-7.76), hypertriglyceridemia (OR = 2.46, 95% CI = 1.28-4.76) and marginally significantly higher odds for insulin resistance (OR = 1.68, 95% CI = 0.93-3.02) after controlling for potential confounders.
   Conclusions: Within severely mentally ill patients, insomnia symptoms are associated with metabolic syndrome and insulin resistance. It appears that insomnia symptoms are independent clinical indicators of underlying metabolic syndrome in patients with severe psychiatric disorders. (C) 2021 Elsevier B.V. All rights reserved.
C1 [Zhang, Wenjuan; Sun, Qimeng; Chen, Baixin; Xu, Chongtao; Li, Yun] Shantou Univ, Mental Hlth Ctr, Dept Sleep Med, North Tai Shan Rd, Shantou 515065, Guangdong, Peoples R China.
   [Zhang, Wenjuan; Sun, Qimeng; Chen, Baixin; Xu, Chongtao; Li, Yun] Shantou Univ, Coll Med, Sleep Med Ctr, Shantou, Guangdong, Peoples R China.
   [Basta, Maria] Univ Hosp Heraklion, Dept Psychiat, Iraklion, Crete, Greece.
C3 Shantou University; Shantou University; University Hospital of Heraklion
RP Li, Y (corresponding author), Shantou Univ, Mental Hlth Ctr, Dept Sleep Med, North Tai Shan Rd, Shantou 515065, Guangdong, Peoples R China.
EM s_liyun@stu.edu.cn
RI 孙, 启蒙/W-7034-2019; Basta, Maria/AAN-8744-2021; Chen,
   Baixin/KQT-9069-2024
OI Chen, Baixin/0000-0002-1884-4960; Basta, Maria/0000-0002-6629-8482
FU National Natural Science Foundation of China [81970087]; Special Funding
   for Science and Technology of Guangdong Province in 2020 [SKJZX202001];
   2020 Li Ka Shing Foundation Cross-Disciplinary Research Grant
   [2020LKSFG05B]
FX This study was supported by National Natural Science Foundation of China
   (No.81970087), Special Funding for Science and Technology of Guangdong
   Province in 2020 (SKJZX202001) and 2020 Li Ka Shing Foundation
   Cross-Disciplinary Research Grant (2020LKSFG05B).
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NR 54
TC 13
Z9 14
U1 0
U2 19
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1389-9457
EI 1878-5506
J9 SLEEP MED
JI Sleep Med.
PD JUL
PY 2021
VL 83
BP 168
EP 174
DI 10.1016/j.sleep.2021.03.030
EA MAY 2021
PG 7
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology
GA SV3EG
UT WOS:000663705100024
PM 34022493
DA 2025-06-11
ER

PT J
AU de Castro, JM
   Assumpçao, JAF
   Stein, DJ
   Toledo, RS
   da Silva, LS
   Caumo, W
   Carraro, CC
   Araujo, ASD
   Torres, ILS
AF de Castro, Josimar Macedo
   Fagundes Assumpcao, Jose Antonio
   Stein, Dirson Joao
   Toledo, Roberta Stroher
   da Silva, Lisiane Santos
   Caumo, Wolnei
   Carraro, Cristina Campos
   da Rosa Araujo, Alex Sander
   Torres, Iraci L. S.
TI Nicotinamide riboside reduces cardiometabolic risk factors and modulates
   cardiac oxidative stress in obese Wistar rats under caloric restriction
SO LIFE SCIENCES
LA English
DT Article
DE Nicotinamide riboside 1; Caloric restriction 2; Oxidative stress 3;
   Obesity 4; Metabolic syndrome 5; Cardiovascular diseases 6; Cafeteria
   diet 7; Animal model 8
ID LEFT-VENTRICULAR HYPERTROPHY; NADPH OXIDASE ACTIVATION; HIGH-FAT DIET;
   ENERGY-EXPENDITURE; INSULIN-RESISTANCE; LIFE-SPAN; NAD(+); METABOLISM;
   PROTECTS; TISSUES
AB Aims: NAD-based therapeutic strategies are encouraged against obesity and heart disease. Our study, therefore, aimed to investigate the effects of nicotinamide riboside (NR), isolated or combined with caloric restriction (CR), both approaches well-known for stimulating NAD levels, on adiposity parameters, cardiometabolic factors and cardiac oxidative stress in rats submitted to cafeteria diet (CAF). Main methods: After 42 days of CAF-induced obesity (hypercaloric and ultra-processed foods common to humans), we examined the effects of oral administration of NR (400 mg/kg for 28 days), combined or not with CR (-62% kcal, for 28 days), on anthropometric, metabolic, tissue, and cardiac oxidative stress parameters in obese male Wistar rats. Key findings: In obese rats, treatment with NR alone mitigated final body weight gain, reduced adiposity (visceral and subcutaneous), improved insulin resistance, and decreased TG/HDL ratio and heart size. In cardiac OS, treatment with NR increased the antioxidant capacity via glutathione peroxidase and catalase enzymes (in rats under CR) as well as reduced the pro-oxidant complex NADPH oxidase (in obese and lean rats). Hyperglycemia, hypertriglyceridemia and elevated levels of TBARS in the heart were state-dependent adverse effects, induced by treatment with NR. Significance: This is the first study to report effects of nicotinamide riboside on cardiac oxidative stress in an obesity model. Nicotinamide riboside, a natural dietary compound, presented antiobesity effects and cardiometabolic benefits, in addition to positively modulating oxidative stress in the heart, in a state-dependent manner.
C1 [de Castro, Josimar Macedo; Toledo, Roberta Stroher; Torres, Iraci L. S.] Univ Fed Rio Grande do Sul UFRGS, Inst Ciencias Basicas Saude ICBS, Programa Posgrad Ciencias Biol PPG Farmacol & Ter, Porto Alegre, RS, Brazil.
   [de Castro, Josimar Macedo; Fagundes Assumpcao, Jose Antonio; Stein, Dirson Joao; Toledo, Roberta Stroher; da Silva, Lisiane Santos; Torres, Iraci L. S.] Hosp Clin Porto Alegre HCPA, Lab Farmacol Dor & Neuromodulacao Invest Preclin, Porto Alegre, RS, Brazil.
   [Carraro, Cristina Campos; da Rosa Araujo, Alex Sander] Univ Fed Rio Grande do Sul, Lab Fisiol Cardiovasc & Especies Reat Oxigenio, Dept Fisiol, ICBS, Porto Alegre, RS, Brazil.
   [Fagundes Assumpcao, Jose Antonio; Stein, Dirson Joao; da Silva, Lisiane Santos; Caumo, Wolnei; Torres, Iraci L. S.] Univ Fed Rio Grande do Sul, Programa Posgrad Med Ciencias Med, Fac Med, Porto Alegre, RS, Brazil.
C3 Universidade Federal do Rio Grande do Sul; Hospital de Clinicas de Porto
   Alegre; Universidade Federal do Rio Grande do Sul; Universidade Federal
   do Rio Grande do Sul
RP Torres, ILS (corresponding author), Hosp Clin Porto Alegre, Rua Ramiro Barcelos 2350, BR-90035903 Porto Alegre, RS, Brazil.
EM iltorres@hcpa.edu.br
RI Assumpcao, Jose/HCH-7547-2022; caumo, wolnei/Q-8728-2016; da Rosa
   Araujo, Alex/E-7519-2011; Campos, Cristina/HLX-6444-2023; Torres, Iraci
   LS/G-6693-2012; Stein, Dirson/N-9242-2014; Assumpcao, Jose/P-6588-2018
OI Macedo de Castro, Josimar/0000-0002-2354-9704; Campos,
   Cristina/0000-0001-6054-4243; Torres, Iraci LS/0000-0002-3081-115X;
   Stein, Dirson/0000-0003-0696-0195; Assumpcao, Jose/0000-0002-2836-1583;
   Caumo, Wolnei/0000-0002-5083-4658
FU Foundation for Research of the State of Rio Grande do Sul FAPERGS;
   Doc-Fix 2018/FAPERGS; National Council for Scientific and Technological
   Development - CNPq; Brazilian Committee for the Development of Higher
   Education Personnel - CAPES; Graduate Research Group of Hospital de
   Clinicas de Porto Alegre - GPPG [16-0558]
FX This research was supported by the following Brazilian funding agencies:
   Foundation for Research of the State of Rio Grande do Sul FAPERGS (J.M.
   de Castro), Doc-Fix 2018/FAPERGS (Dr. J.A.F. Assumpcao), National
   Council for Scientific and Technological Development -CNPq (Dr. I.L.S.
   Torres, Dr. A.S.R. Araujo, Dr. W. Caumo); Brazilian Committee for the
   Development of Higher Education Personnel -CAPES (Dr. D.J. Stein, R.
   Stroher Toledo); Graduate Research Group of Hospital de Clinicas de
   Porto Alegre -GPPG (I.L.S. Torres -Grant #16-0558).
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NR 91
TC 16
Z9 16
U1 0
U2 4
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0024-3205
EI 1879-0631
J9 LIFE SCI
JI Life Sci.
PD DEC 15
PY 2020
VL 263
AR 118596
DI 10.1016/j.lfs.2020.118596
PG 12
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA PE1KN
UT WOS:000598130200002
PM 33080243
OA Bronze
DA 2025-06-11
ER

PT J
AU Dickens, GL
   Salamonson, Y
   Ramjan, L
   Steel, K
   Everett, B
AF Dickens, Geoffrey L.
   Salamonson, Yenna
   Ramjan, Lucie
   Steel, Kelly
   Everett, Bronwyn
TI Safety attitudes, perceived organizational culture and knowledge of the
   physiologically deteriorating patient among mental health nurses:
   Cross-sectional, correlational study
SO INTERNATIONAL JOURNAL OF MENTAL HEALTH NURSING
LA English
DT Article
DE attitudes; emergency medicine; mental health; organizational culture;
   physical healthcare; safety
ID METABOLIC SYNDROME; CARE; PEOPLE; QUESTIONNAIRE; EMERGENCY
AB Mental health nurses have traditionally lagged in terms of physical healthcare skills and have been found to have poorer cultural safety-related attitudes relative to other nurses. Organizational culture, including safety-related culture, is associated with important aspects of care quality. The aim of the current study was to examine the relationships between safety-related attitudes, physical healthcare-related knowledge and organizational culture among mental health nurses. By doing so, the intention was to inform decisions about interventions to improve attitudes and care related to severe physiological deterioration among mental health nurses. The study design was cross-sectional and correlational. The safety-related attitudes of N = 133 nurses from the inpatient mental health services of one Local Health District in New South Wales, Australia, were examined in terms of a range of potential predictor variables of safety attitudes (Safety Attitudes Questionnaire) including individual organizational-perceiver type (Organisational Climate Assessment Inventory), knowledge of emergency medical healthcare (Lambeth In situ Training Questionnaire), use and perception of medical emergency teams (purpose-designed questionnaire) and a range of demographic variables. Regression analyses revealed that those who perceived the organization to have a primarily market-oriented culture had poorer safety-related attitudes than those who perceived a more clan-type culture. Number of years qualified was negatively associated with safety attitudes. To our knowledge, this is the first study in mental health which demonstrates a link between organizational culture-perception and safety attitudes related to physical healthcare. Results suggest that, among nurses, individuals have quite different perceptions of the organizational culture. In turn, this suggests that the 'one-size fits all' approach to changing organizational culture may be inappropriate.
C1 [Dickens, Geoffrey L.] Ingham Inst Med Res, Ctr Appl Nursing Res, Campbell St, Liverpool, NSW 2170, Australia.
   [Dickens, Geoffrey L.; Salamonson, Yenna; Ramjan, Lucie; Everett, Bronwyn] Western Sydney Univ, Sch Nursing & Midwifery, Penrith, NSW, Australia.
   [Dickens, Geoffrey L.; Steel, Kelly] South West Sydney Local Hlth Dist, Liverpool, NSW, Australia.
C3 Ingham Institute for Applied Medical Research; Western Sydney
   University; South Western Sydney Local Health District
RP Dickens, GL (corresponding author), Ingham Inst Med Res, Ctr Appl Nursing Res, Campbell St, Liverpool, NSW 2170, Australia.
EM g.dickens@westernsydney.edu.au
RI Dickens, Geoffrey/AFM-7618-2022; Everett, Bronwyn/AAT-1308-2021; Ramjan,
   Lucie/E-2212-2016; Salamonson, Yenna/AAX-4499-2020
OI Everett, Bronwyn/0000-0003-1733-7462; Dickens,
   Geoffrey/0000-0002-8862-1527
FU New South Wales Health Nursing and Midwifery Office
FX The study was funded as part of grant to author BE by the New South
   Wales Health Nursing and Midwifery Office. The funder played no part in
   the design or conduct of the study or in the decision to publish, or the
   content of publication.
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NR 44
TC 7
Z9 10
U1 0
U2 10
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1445-8330
EI 1447-0349
J9 INT J MENT HEALTH NU
JI Int. J. Ment. Health Nurs.
PD DEC
PY 2019
VL 28
IS 6
BP 1347
EP 1362
DI 10.1111/inm.12649
EA SEP 2019
PG 16
WC Nursing; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Psychiatry
GA JM5QQ
UT WOS:000485495000001
PM 31498959
DA 2025-06-11
ER

PT J
AU Evangelopoulos, AA
   Vallianou, NG
   Panagiotakos, DB
   Georgiou, AT
   Zacharias, GA
   Vogiatzakis, ED
   Avgerinos, PC
AF Evangelopoulos, Angelos A.
   Vallianou, Natalia G.
   Panagiotakos, Demosthenes B.
   Georgiou, Aikaterini T.
   Zacharias, Georgios A.
   Vogiatzakis, Evangelos D.
   Avgerinos, Peter C.
TI The Association Between Uric Acid and Hepatic Function Markers With the
   Metabolic Syndrome in Middle-aged, Overweight, and Obese People
SO ENDOCRINOLOGIST
LA English
DT Article
DE metabolic syndrome; gamma-glutamyltransferase; alanine aminotransferase;
   aspartate aminotransferase; uric acid
ID GAMMA-GLUTAMYL-TRANSPEPTIDASE; CARDIOVASCULAR-DISEASE;
   ALCOHOL-CONSUMPTION; OXIDATIVE STRESS; YOUNG-ADULTS; RISK;
   ATHEROSCLEROSIS; GLUTAMYLTRANSFERASE; MEN; TRANSFERASE
AB The role of hepatic and renal function on the development of the metabolic syndrome is not well studied in obese, middle-aged, and elderly people. We enrolled 117 consecutive overweight or obese patients and measured their aspartate aminotransferase, alanine aminotransferase, gamma-glutamyltransferase, alkaline phosphatase, and serum uric acid levels. In all, 82 patients (70%) had the metabolic syndrome. Patients with the metabolic syndrome had considerably increased serum uric acid, alanine aminotransferase, and gamma-glutamyltransferase levels. Moreover, serum uric acid, alanine aminotransferase, and gamma-glutamyltransferase levels increased as the number of components of the metabolic syndrome increased. These biochemical markers could help identify patients with the metabolic syndrome who are at increased risk for future cardiovascular events. The above-mentioned markers seem to have a diagnostic ability in classifying obese people with metabolic syndrome. Whether by lowering serum uric acid and gamma-glutamyltransferase levels with the use of drugs or simply by avoiding alcohol consumption could we ameliorate cardiovascular risk among patients with the metabolic syndrome, remains to be elucidated.
C1 [Evangelopoulos, Angelos A.; Vogiatzakis, Evangelos D.] Polyklin Gen Hosp, Dept Biochem, Athens, Greece.
   [Vallianou, Natalia G.; Georgiou, Aikaterini T.; Zacharias, Georgios A.; Avgerinos, Peter C.] Polyklin Gen Hosp, Dept Internal Med, Athens, Greece.
   [Panagiotakos, Demosthenes B.] Harokopio Univ, Dept Nutr Sci & Dietet, Athens, Greece.
C3 Harokopio University Athens
RP Evangelopoulos, AA (corresponding author), 54A Akak St, Athens 15125, Greece.
EM aevangelopoulos@hotmail.com
RI Panagiotakos, Demosthenes/K-8294-2019
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NR 30
TC 2
Z9 2
U1 1
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1051-2144
J9 ENDOCRINOLOGIST
JI Endocrinologist
PD NOV-DEC
PY 2010
VL 20
IS 6
BP 312
EP 315
DI 10.1097/TEN.0b013e318204d6e9
PG 4
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 694XU
UT WOS:000285336000020
DA 2025-06-11
ER

PT J
AU Hao, Y
   Zhu, YJ
   Zou, S
   Zhou, P
   Hu, YW
   Zhao, QX
   Gu, LN
   Zhang, HZ
   Wang, Z
   Li, J
AF Hao, Yan
   Zhu, Ya-juan
   Zou, Song
   Zhou, Pei
   Hu, Ya-wen
   Zhao, Qi-xiang
   Gu, Lin-na
   Zhang, Hao-zhou
   Wang, Zhen
   Li, Jiong
TI Metabolic Syndrome and Psoriasis: Mechanisms and Future Directions
SO FRONTIERS IN IMMUNOLOGY
LA English
DT Review
DE psoriasis; metabolic syndrome; gut microbiota; insulin resistance;
   autoimmunity; obesity
ID ENDOPLASMIC-RETICULUM STRESS; IMPROVES INSULIN SENSITIVITY; FATTY
   LIVER-DISEASE; ALPHA TNF-ALPHA; OXIDATIVE STRESS;
   AKKERMANSIA-MUCINIPHILA; RHEUMATOID-ARTHRITIS; DIABETES-MELLITUS;
   ADIPONECTIN; INFLAMMATION
AB Psoriasis is an immune-mediated systemic disease with associated comorbidities, including metabolic syndrome (MetS) which contributes substantially to premature mortality in patients with psoriasis. However, the pathological mechanisms underlying this comorbidity are unclear. Studies have shown that the pathological parameters of psoriasis mediate the development of MetS. We reviewed the potential mechanisms which mediate the association between psoriasis and MetS, including endoplasmic reticulum stress, pro-inflammatory cytokine releases, excess production of reactive oxygen species, alterations in adipocytokine levels and gut microbiota dysbiosis. Here, we highlight important research questions regarding this association and offer insights into MetS research and treatment.
C1 [Hao, Yan; Zhou, Pei; Hu, Ya-wen; Zhao, Qi-xiang; Gu, Lin-na; Zhang, Hao-zhou; Wang, Zhen; Li, Jiong] Sichuan Univ, West China Med Sch, West China Hosp, State Key Lab Biotherapy, Chengdu, Peoples R China.
   [Hao, Yan; Zhou, Pei; Hu, Ya-wen; Zhao, Qi-xiang; Gu, Lin-na; Zhang, Hao-zhou; Wang, Zhen; Li, Jiong] Sichuan Univ, West China Med Sch, West China Hosp, Canc Ctr, Chengdu, Peoples R China.
   [Hao, Yan; Zhou, Pei; Hu, Ya-wen; Zhao, Qi-xiang; Gu, Lin-na; Zhang, Hao-zhou; Wang, Zhen; Li, Jiong] Collaborat Innovat Ctr Biotherapy, Chengdu, Peoples R China.
   [Zhu, Ya-juan] Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Dept Biotherapy, Chengdu, Peoples R China.
   [Zhu, Ya-juan] Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Canc Ctr, Chengdu, Peoples R China.
   [Zou, Song] Sichuan Univ, West China Hosp, Dept Cardiol, Chengdu, Peoples R China.
   [Wang, Zhen] Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Dept Liver Surg & Liver Transplantat, Chengdu, Peoples R China.
   [Wang, Zhen] Sichuan Univ, West China Hosp, Canc Ctr, Chengdu, Peoples R China.
   [Wang, Zhen] Sichuan Univ, West China Hosp, Lab Liver Surg, Chengdu, Peoples R China.
C3 Sichuan University; Sichuan University; Sichuan University; Sichuan
   University; Sichuan University; Sichuan University; Sichuan University;
   Sichuan University
RP Wang, Z; Li, J (corresponding author), Sichuan Univ, West China Med Sch, West China Hosp, State Key Lab Biotherapy, Chengdu, Peoples R China.; Wang, Z; Li, J (corresponding author), Sichuan Univ, West China Med Sch, West China Hosp, Canc Ctr, Chengdu, Peoples R China.; Wang, Z; Li, J (corresponding author), Collaborat Innovat Ctr Biotherapy, Chengdu, Peoples R China.; Wang, Z (corresponding author), Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Dept Liver Surg & Liver Transplantat, Chengdu, Peoples R China.; Wang, Z (corresponding author), Sichuan Univ, West China Hosp, Canc Ctr, Chengdu, Peoples R China.; Wang, Z (corresponding author), Sichuan Univ, West China Hosp, Lab Liver Surg, Chengdu, Peoples R China.
EM wangzhenkeepmoving@163.com; lijionghh@sina.com
RI LI, JIONG/KHD-3773-2024; gu, linna/HKO-7632-2023; Hu,
   Yawen/MFI-2240-2025; zhou, pei/AFH-8802-2022; Zhao,
   Qixiang/HJZ-1103-2023
OI Zhao, Qixiang/0000-0002-0306-9762; Wang, Zhen/0000-0002-2516-4752
FU National Natural Science Foundation of China [81673061, 81472650,
   31271483, 81703132]; National Science and Technology Major Project
   [2018ZX09303006-001-006, 2019ZX09201004-003]; Key Research and
   Development Program of Sichuan Province [2020YFS0271]; Applied Basic
   Research Program of Sichuan Province [2021YJ0420]; Postdoctoral Fund for
   West China Hospital [2019HXBH075]; Fundamental Research Funds for the
   Central Universities [Postdoctoral Foundation of Sichuan University]
   [2019SCU12041]
FX This work was supported by the National Natural Science Foundation of
   China (81673061 to J. Li, 81472650 to J. Li, 31271483 to J. Li, 81703132
   to Z. Wang), the National Science and Technology Major Project
   (2018ZX09303006-001-006 to J. Li and 2019ZX09201004-003 to J. Li), the
   Key Research and Development Program of Sichuan Province [2020YFS0271],
   the Applied Basic Research Program of Sichuan Province [2021YJ0420], the
   Postdoctoral Fund for West China Hospital [2019HXBH075], the Fundamental
   Research Funds for the Central Universities [2019SCU12041, the
   Postdoctoral Foundation of Sichuan University].
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NR 141
TC 88
Z9 89
U1 4
U2 36
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-3224
J9 FRONT IMMUNOL
JI Front. Immunol.
PD JUL 23
PY 2021
VL 12
AR 711060
DI 10.3389/fimmu.2021.711060
PG 10
WC Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology
GA TV3PT
UT WOS:000681635900001
PM 34367173
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Benson, J
   Severn, C
   Hudnut-Beumler, J
   Simon, SL
   Abramson, N
   Shomaker, LB
   Gulley, LD
   Taylor, A
   Kelsey, MM
   Nadeau, KJ
   Zeitler, PS
   Pyle, L
   Cree-Green, M
AF Benson, Jessie
   Severn, Cameron
   Hudnut-Beumler, Julia
   Simon, Stacey L.
   Abramson, Natalie
   Shomaker, Lauren B.
   Gulley, Lauren D.
   Taylor, Anya
   Kelsey, Megan M.
   Nadeau, Kristen J.
   Zeitler, Philip S.
   Pyle, Laura
   Cree-Green, Melanie
TI Depression in Girls With Obesity and Polycystic Ovary Syndrome and/or
   Type 2 Diabetes
SO CANADIAN JOURNAL OF DIABETES
LA English
DT Article
DE adolescents; depression; polycystic ovary syndrome; type 2 diabetes
ID PREVALENCE; SYMPTOMS; POPULATION; SEARCH; LIFE
AB Objectives: Polycystic ovary syndrome (PCOS) is a common reproductive/metabolic condition associated with obesity, type 2 diabetes (T2D) and depression in adult women. Depression in adults is related to PCOS dermatologic manifestations. Adolescents with obesity with or without T2D have elevated depression symptoms, but data from youth with PCOS and obesity with/without T2D are limited.
   Methods: Our study included girls, aged 11 to 17 years, with obesity and PCOS, PCOS+T2D or T2D, who were newly seen in an obesity complications clinic after March 2016. All participants had Center for Epidemiologic Studies-Depression (CES-D, 20 items) scores obtained within 6 months of PCOS or T2D diagnosis. Data on history of psychiatric diagnosis and treatment, metabolic syndrome and severity of acne and hirsutism were collected through chart review.
   Results: One hundred five girls (47 with PCOS, 14 with PCOSthornT2D, 44 with T2D) had similar age (15 +/- 1.8 years) and body mass index z scores (2.2 +/- 0.4). CES-D scores >= 16, indicating elevated depression symptoms, and CES-D scores >= 24, indicating severe depression symptoms, were observed in 60% and 30% of girls with PCOS, 78% and 71% of those with PCOSthornT2D and 39% and 21% of those with T2D, respectively (p<0.0001 for both cutpoints). A higher CES-D score was not associated with severity of hirsutism or acne (p>0.05 for both).
   Conclusions: Adolescents with PCOS and obesity have higher rates of elevated depression symptoms compared with girls with T2D, which is not related to worse dermatologic symptoms. Because depression may impact both PCOS and T2D management and adherence to therapy, greater efforts should be made to screen for and address mental health in adolescents with PCOS and obesity, especially if T2D is present. (C) 2020 Canadian Diabetes Association.
C1 [Benson, Jessie; Abramson, Natalie; Shomaker, Lauren B.; Gulley, Lauren D.; Taylor, Anya; Kelsey, Megan M.; Nadeau, Kristen J.; Zeitler, Philip S.; Cree-Green, Melanie] Univ Colorado, Dept Pediat, Div Pediat Endocrinol, Anschutz Med Campus, POB 265,13123 East 16th Ave, Aurora, CO 80045 USA.
   [Severn, Cameron; Pyle, Laura] Colorado Sch Publ Hlth, Dept Biostat & Informat, Aurora, CO USA.
   [Hudnut-Beumler, Julia; Simon, Stacey L.; Pyle, Laura] Univ Colorado, Dept Pediat, Anschutz Med Campus, Aurora, CO USA.
   [Simon, Stacey L.; Kelsey, Megan M.; Nadeau, Kristen J.; Cree-Green, Melanie] Univ Colorado, Ctr Womens Hlth Res, Anschutz Med Campus, Aurora, CO USA.
   [Shomaker, Lauren B.; Gulley, Lauren D.] Colorado State Univ, Dept Human Dev & Family Studies, Ft Collins, CO 80523 USA.
C3 University of Colorado System; University of Colorado Anschutz Medical
   Campus; Colorado School of Public Health; University of Colorado System;
   University of Colorado Anschutz Medical Campus; University of Colorado
   System; University of Colorado Anschutz Medical Campus; Colorado State
   University System; Colorado State University Fort Collins
RP Cree-Green, M (corresponding author), Univ Colorado, Dept Pediat, Div Pediat Endocrinol, Anschutz Med Campus, POB 265,13123 East 16th Ave, Aurora, CO 80045 USA.
EM melanie.green@childrenscolorado.org
RI Cree, Melanie/S-9494-2019; Simon, Stacey/G-9882-2016
OI Severn, Cameron/0000-0001-9562-581X; Kelsey, Megan/0000-0002-0755-1951;
   Benson, Jessie/0000-0002-5103-3959; Simon, Stacey/0000-0003-4755-8151
FU National Institute of Diabetes and Digestive and Kidney Diseases
   [K23DK107871]; Children's Hospital Colorado
FX M.C.-G. was supported by a grant from the National Institute of Diabetes
   and Digestive and Kidney Diseases (K23DK107871) and also by Children's
   Hospital Colorado.
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NR 23
TC 17
Z9 18
U1 2
U2 5
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1499-2671
EI 2352-3840
J9 CAN J DIABETES
JI Can. J. Diabetes
PD AUG
PY 2020
VL 44
IS 6
BP 507
EP 513
DI 10.1016/j.jcjd.2020.05.015
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA NA4AY
UT WOS:000559758100009
PM 32792104
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Guerrero, APS
   Fung, D
   Suaalii-Sauni, T
   Wiguna, T
AF Guerrero, Anthony P. S.
   Fung, Daniel
   Suaalii-Sauni, Tamasailau
   Wiguna, Tjhin
TI Care for the seafarers: A review of mental health in Austronesia
SO ASIA-PACIFIC PSYCHIATRY
LA English
DT Review
DE Asia; healthcare disparities; mental health; Pacific Islands;
   Southeastern
ID NEW-ZEALAND; CULTURAL IDENTIFICATION; ADOLESCENTS; PREVALENCE;
   ACCULTURATION; SCHIZOPHRENIA; PSYCHIATRY; HAWAIIAN; PACIFIC; ISLAND
AB Introduction: Continent-based regional reviews of mental health may not fully describe the status of ethnocultural groups that are widely dispersed across multiple continents or traditional world regions. Our aim was to describe the Austronesians, an ethno-linguistic group living primarily in islands and coastal areas in the Pacific and Indian Oceans and Southeast Asia. Methods: Consulting lay databases, we created matrices to describe the demographic, political, and socioeconomic profiles of nations with majority and minority indigenous Austronesian language-speaking populations. We then accessed the scientific literature to describe examples of mental health disparities and/or challenges in mental health care delivery. Results: Many Austronesian-speaking people have experienced recent or current foreign occupation, lack of recognized sovereignty, poverty and low socioeconomic status, and low availability of psychiatric resources and providers. An analysis of the biological, psychological/psychocultural, and social and environmental impacts (risk or protective) on either the prevalence/presentation of mental illness, help-seeking behavior or access to mental health care, or management of mental illness suggested that there may be relatively unique stressors (e.g. loss of homeland from either global warming or nuclear contamination) affecting people in this region and certain biological profiles (e.g. susceptibility to obesity and metabolic syndrome) that may impact psychiatric treatment. Discussion: Solutions to mental health challenges in this world region may include culturally relevant and integrative mental healthcare delivery models; resource preserving, prevention-focused universal mental healthcare; and technology to improve connectivity and increase access to either direct services or workforce-building education and training.
C1 [Guerrero, Anthony P. S.] Univ Hawaii Manoa, John A Burns Sch Med, Honolulu, HI 96813 USA.
   [Fung, Daniel] Natl Univ Singapore, Yong Loo Lin Sch Med, Singapore 117595, Singapore.
   [Fung, Daniel] Natl Univ Singapore, Duke NUS Grad Med Sch, Singapore 117595, Singapore.
   [Fung, Daniel] Inst Mental Hlth, Singapore, Singapore.
   [Suaalii-Sauni, Tamasailau] Victoria Univ Wellington, Vaaomanu Pasifika Unit, Wellington, New Zealand.
   [Wiguna, Tjhin] Univ Indonesia, Div Child & Adolescent Psychiat, Dept Psychiat, Jakarta, Indonesia.
C3 University of Hawaii System; University of Hawaii Manoa; National
   University of Singapore; National University of Singapore; Victoria
   University Wellington; University of Indonesia
RP Guerrero, APS (corresponding author), Univ Hawaii Manoa, John A Burns Sch Med, 1356 Lusitana St,4th Floor, Honolulu, HI 96813 USA.
EM guerreroa@dop.hawaii.edu
RI Fung, Daniel/W-6915-2019
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NR 104
TC 9
Z9 9
U1 1
U2 28
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1758-5864
EI 1758-5872
J9 ASIA-PAC PSYCHIAT
JI Asia-Pac. Psychiatry
PD SEP
PY 2013
VL 5
IS 3
BP 119
EP 140
DI 10.1111/appy.12031
PG 22
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 202XN
UT WOS:000323254200002
PM 23857781
DA 2025-06-11
ER

PT J
AU Pesqueda-Cendejas, K
   Rivera-Escoto, M
   Meza-Meza, MR
   Campos-Lopez, B
   Parra-Rojas, I
   Montoya-Buelna, M
   de la Cruz-mosso, U
AF Pesqueda-Cendejas, Karen
   Rivera-Escoto, Melissa
   Meza-Meza, Monica R.
   Campos-Lopez, Bertha
   Parra-Rojas, Isela
   Montoya-Buelna, Margarita
   de la Cruz-mosso, Ulises
TI Nutritional Approaches to Modulate Cardiovascular Disease Risk in
   Systemic Lupus Erythematosus: A Literature Review
SO NUTRIENTS
LA English
DT Review
DE systemic lupus erythematosus; cardiovascular disease risk; dyslipidemia;
   hypertension; hyperhomocysteinemia; C-reactive protein
ID REACTIVE PROTEIN-LEVELS; PHYSICAL-ACTIVITY; MYOCARDIAL-INFARCTION;
   ENDOTHELIAL FUNCTION; FUNCTIONAL-CAPACITY; OXIDATIVE STRESS;
   DOUBLE-BLIND; FATTY-ACIDS; MOUSE MODEL; FOLIC-ACID
AB Systemic lupus erythematosus (SLE) is a chronic pathology characterized by a bimodal mortality pattern attributed to clinical disease activity and cardiovascular disease (CVD). A complex interaction between traditional CVD risk factors such as obesity, dyslipidemia, smoking, insulin resistance, metabolic syndrome, and hypertension, as well as the presence of non-traditional CVD risk factors such as hyperhomocysteinemia, pro-inflammatory cytokines, and C-reactive protein levels, has been suggested as a cause of the high prevalence of CVD in SLE patients. On the other hand, environmental factors, such as nutritional status, could influence the disease's prognosis; several nutrients have immunomodulators, antioxidants, and anti-cardiometabolic risk properties which could reduce SLE severity and organ damage by decreasing the development of traditional and non-traditional CVD risk factors. Therefore, this critical literature review discusses the therapeutic potential of nutritional approaches that could modulate the development of the main comorbidities related to CVD risk in SLE patients.
C1 [Pesqueda-Cendejas, Karen; Rivera-Escoto, Melissa; Meza-Meza, Monica R.; Campos-Lopez, Bertha; Parra-Rojas, Isela; Montoya-Buelna, Margarita; de la Cruz-mosso, Ulises] Univ Guadalajara, Ctr Univ Ciencias Salud, Red Inmunonutr & Genomica Nutr Enfermedades Autoin, Guadalajara 44340, Jalisco, Mexico.
   [Pesqueda-Cendejas, Karen; Rivera-Escoto, Melissa; Meza-Meza, Monica R.; Campos-Lopez, Bertha; de la Cruz-mosso, Ulises] Univ Guadalajara, Ctr Univ Ciencias Salud, Dept Neurociencias, Inst Neurociencias Traslac, Guadalajara 44340, Jalisco, Mexico.
   [Pesqueda-Cendejas, Karen; de la Cruz-mosso, Ulises] Univ Guadalajara, Ctr Univ Ciencias Salud, Programa Doctorado Ciencias Nutr Traslac, Guadalajara 44340, Jalisco, Mexico.
   [Rivera-Escoto, Melissa; Meza-Meza, Monica R.; de la Cruz-mosso, Ulises] Univ Guadalajara, Ctr Univ Ciencias Salud, Programa Doctorado Ciencias Biomed Orientac Inmuno, Guadalajara 44340, Jalisco, Mexico.
   [Campos-Lopez, Bertha] Univ Guadalajara, Ctr Univ Ciencias Salud, Programa Doctorado Ciencias Biol Mol Med, Guadalajara 44340, Jalisco, Mexico.
   [Parra-Rojas, Isela] Univ Autonoma Guerrero, Fac Ciencias Quim Biol, Lab Invest Obes & Diabet, Guerrero 39087, Mexico.
   [Montoya-Buelna, Margarita] Ctr Univ Ciencias Salud, Univ Guadalajara, Dept Fisiol, Lab Inmunol, Guadalajara 44340, Jalisco, Mexico.
C3 Universidad de Guadalajara; Universidad de Guadalajara; Universidad de
   Guadalajara; Universidad de Guadalajara; Universidad de Guadalajara;
   Universidad de Guadalajara
RP de la Cruz-mosso, U (corresponding author), Univ Guadalajara, Ctr Univ Ciencias Salud, Red Inmunonutr & Genomica Nutr Enfermedades Autoin, Guadalajara 44340, Jalisco, Mexico.; de la Cruz-mosso, U (corresponding author), Univ Guadalajara, Ctr Univ Ciencias Salud, Dept Neurociencias, Inst Neurociencias Traslac, Guadalajara 44340, Jalisco, Mexico.; de la Cruz-mosso, U (corresponding author), Univ Guadalajara, Ctr Univ Ciencias Salud, Programa Doctorado Ciencias Nutr Traslac, Guadalajara 44340, Jalisco, Mexico.; de la Cruz-mosso, U (corresponding author), Univ Guadalajara, Ctr Univ Ciencias Salud, Programa Doctorado Ciencias Biomed Orientac Inmuno, Guadalajara 44340, Jalisco, Mexico.
EM ulises_cdm@hotmail.com
RI de la Cruz-Mosso, Ulises/GMX-1036-2022; MONTOYA BUELNA,
   Margarita/LJL-6340-2024; Rivera Escoto, Melissa/JED-6658-2023;
   Parra-Rojas, Isela/E-5211-2013
OI Meza-Meza, Monica R./0000-0003-4991-4965; Parra-Rojas,
   Isela/0000-0002-9213-8263; Rivera Escoto, Melissa/0000-0001-9069-7478;
   pesqueda cendejas, karen/0000-0002-6849-5965; De la Cruz-Mosso,
   Ulises/0000-0003-4579-2294; Montoya Buelna,
   Margarita/0000-0001-9309-1957; Campos-Lopez, Bertha/0000-0002-1667-8794
FU Grant "Programa de Apoyo a laMejora en las Condiciones de Produccion de
   los Miembros del SNI y SNCA 2019-2022" from the Universidad de
   Guadalajara for Ulises de la Cruz-Mosso; Grant "Programa de Impulso a la
   Investigacion (PIN) 2020" from the Universidad de Guadalajara for Ulises
   de la Cruz-Mosso
FX The authors acknowledge the support of the Grant "Programa de Apoyo a
   laMejora en las Condiciones de Produccion de los Miembros del SNI y SNCA
   2019-2022" (U.D.l.C.-M.), and the Grant "Programa de Impulso a la
   Investigacion (PIN) 2020" (U.D.l.C.-M.) from the Universidad de
   Guadalajara for Ulises de la Cruz-Mosso (U.D.l.C.-M.).
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NR 122
TC 8
Z9 9
U1 1
U2 2
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD FEB
PY 2023
VL 15
IS 4
AR 1036
DI 10.3390/nu15041036
PG 19
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 9L7FU
UT WOS:000941712700001
PM 36839394
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Kim, T
AF Kim, Taehui
TI Quality of Life in Metabolic Syndrome Patients Based on the Risk of
   Obstructive Sleep Apnea
SO BEHAVIORAL SCIENCES
LA English
DT Article
DE metabolic syndrome; sleep apnea; obstructive; quality of life
ID PHYSICAL-ACTIVITY; DEPRESSION; PREVALENCE
AB Despite the impact of metabolic syndrome (MetS) and obstructive sleep apnea (OSA) on a sizeable proportion of the global population, the difference in the quality of life (QoL) between a group without risk factors for OSA and a group with risk factors for OSA among individuals with MetS is currently unclear. This study aimed to identify the determinants of QoL in patients with MetS with and without OSA risk factors and to analyze differences between these two groups. Data were extracted from the 2020 Korea National Health and Nutrition Examination Survey (KNHANES). The Rao-Scott chi 2 test was performed to evaluate differences in baseline characteristics based on OSA risk factors. A t-test was performed to evaluate differences in the baseline QoL, and linear regression analysis was performed to identify the effect on the QoL of the two groups. The factors affecting QoL in the low-risk group included age, education level, and depression. The factors affecting QoL in the high-risk group were physical activity and depression. These results suggest that nursing interventions should be devised according to patients' characteristics to help improve their QoL.
C1 [Kim, Taehui] Joongbu Univ, Dept Nursing Sci, Chungnam 32713, South Korea.
C3 Joongbu University
RP Kim, T (corresponding author), Joongbu Univ, Dept Nursing Sci, Chungnam 32713, South Korea.
EM skyibe@joongbu.ac.kr
FU Joongbu University Research & Development Fund
FX We thank the KDCA for providing the data.
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NR 37
TC 1
Z9 1
U1 2
U2 3
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-328X
J9 BEHAV SCI-BASEL
JI Behav. Sci.
PD FEB
PY 2024
VL 14
IS 2
AR 127
DI 10.3390/bs14020127
PG 11
WC Psychology, Multidisciplinary
WE Social Science Citation Index (SSCI)
SC Psychology
GA IY5M2
UT WOS:001169913700001
PM 38392480
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Soleimani, M
   Barone, S
   Luo, HY
   Zahedi, K
AF Soleimani, Manoocher
   Barone, Sharon
   Luo, Henry
   Zahedi, Kamyar
TI Pathogenesis of Hypertension in Metabolic Syndrome: The Role of Fructose
   and Salt
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE fructose; salt; small intestine; kidney tubules
ID INSULIN-RESISTANCE; OXIDATIVE STRESS; SENSITIVE HYPERTENSION;
   MEDITERRANEAN DIET; BLOOD-PRESSURE; ABSORPTIVE DEFECTS; CHILDHOOD
   OBESITY; PROXIMAL TUBULE; NACL ABSORPTION; LIFE-STYLE
AB Metabolic syndrome is manifested by visceral obesity, hypertension, glucose intolerance, hyperinsulinism, and dyslipidemia. According to the CDC, metabolic syndrome in the US has increased drastically since the 1960s leading to chronic diseases and rising healthcare costs. Hypertension is a key component of metabolic syndrome and is associated with an increase in morbidity and mortality due to stroke, cardiovascular ailments, and kidney disease. The pathogenesis of hypertension in metabolic syndrome, however, remains poorly understood. Metabolic syndrome results primarily from increased caloric intake and decreased physical activity. Epidemiologic studies show that an enhanced consumption of sugars, in the form of fructose and sucrose, correlates with the amplified prevalence of metabolic syndrome. Diets with a high fat content, in conjunction with elevated fructose and salt intake, accelerate the development of metabolic syndrome. This review article discusses the latest literature in the pathogenesis of hypertension in metabolic syndrome, with a specific emphasis on the role of fructose and its stimulatory effect on salt absorption in the small intestine and kidney tubules.
C1 [Soleimani, Manoocher; Barone, Sharon; Zahedi, Kamyar] New Mexico Vet Hlth Care Med Ctr, Res Serv, Albuquerque, NM 87108 USA.
   [Soleimani, Manoocher; Barone, Sharon; Luo, Henry; Zahedi, Kamyar] Univ New Mexico, Dept Med, Sch Med, Albuquerque, NM 87131 USA.
C3 University of New Mexico
RP Soleimani, M (corresponding author), New Mexico Vet Hlth Care Med Ctr, Res Serv, Albuquerque, NM 87108 USA.; Soleimani, M (corresponding author), Univ New Mexico, Dept Med, Sch Med, Albuquerque, NM 87131 USA.
EM msoleimani@salud.unm.edu
RI Zahedi, Kamyar/AAQ-3428-2021; soleimani, m/U-6889-2017
OI zahedi, kamyar/0000-0002-4257-5107; Barone, Sharon/0000-0001-5710-292X;
   Soleimani, Manoocher/0000-0003-4909-4469
FU United States Veterans Administration Department [2I01BX001000-10];
   Dialysis Clinic Inc. [DCI C-4149]; National Institutes of Health
   [NIH/NHLBIT32HL007736]
FX This research was funded by United States Veterans Administration
   Department grant number 2I01BX001000-10, Dialysis Clinic Inc. grant
   number DCI C-4149, National Institutes of Health grant number
   NIH/NHLBIT32HL007736.
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NR 130
TC 29
Z9 30
U1 3
U2 32
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD MAR
PY 2023
VL 24
IS 5
AR 4294
DI 10.3390/ijms24054294
PG 15
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 9U8HG
UT WOS:000947945200001
PM 36901725
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Mohan, J
   Ghazi, T
   Sibiya, T
   Chuturgoon, AA
AF Mohan, Jivanka
   Ghazi, Terisha
   Sibiya, Thabani
   Chuturgoon, Anil A. A.
TI Antiretrovirals Promote Metabolic Syndrome through Mitochondrial Stress
   and Dysfunction: An In Vitro Study
SO BIOLOGY-BASEL
LA English
DT Article
DE metabolic syndrome; ARVs; mitochondrial stress; mitochondrial
   dysfunction; oxidative stress; insulin resistance
ID OXIDATIVE STRESS; INSULIN-RESISTANCE; NRF2; HIV; PATHWAY; HEALTH; SIRT3;
   GENE
AB Simple Summary Antiretrovirals have several side effects. Recently, the use of antiretrovirals has been associated with metabolic syndrome. Metabolic syndrome arises through several abnormalities including mitochondrial dysfunction. The current study aimed to ascertain the effects of singular and combinational usage of current ARVs on mitochondrial dysfunction and its linkage to metabolic syndrome in liver (HepG2) cells. Cells were treated for a period of 120 h using Tenofovir disoproxil fumarate, Lamivudine, and Dolutegravir in singular and combinational doses. Results indicated that ARVs induce mitochondrial stress and dysfunction, which may be closely associated with the progression of insulin resistance. The evidence can be used to develop therapies with reduced side effects related to metabolic syndrome. The prevalence of metabolic syndrome MetS in HIV-infected patients on chronic antiretroviral (ARV) therapy continues to rise rapidly, with an estimated 21% experiencing insulin resistance. The progression of insulin resistance is strongly related to mitochondrial stress and dysfunction. This study aimed to draw links between the singular and combinational use of Tenofovir disoproxil fumarate (TDF), Lamivudine (3TC), and Dolutegravir (DTG) on mitochondrial stress and dysfunction as an underlying mechanism for insulin resistance following a 120 h treatment period using an in vitro system of human liver cells (HepG2). The relative protein expressions of pNrf2, SOD2, CAT, PINK1, p62, SIRT3, and UCP2, were determined using Western blot. Transcript levels of PINK1 and p62 were assessed using quantitative PCR (qPCR). ATP concentrations were quantified using luminometry, and oxidative damage (malondialdehyde (MDA) concentration) was measured using spectrophotometry. The findings suggest that despite the activation of antioxidant responses (pNrf2, SOD2, CAT) and mitochondrial maintenance systems (PINK1 and p62) in selected singular and combinational treatments with ARVs, oxidative damage and reduced ATP production persisted. This was attributed to a significant suppression in mitochondrial stress responses SIRT3 and UCP2 for all treatments. Notable results were observed for combinational treatments with significant increases in pNrf2 (p = 0.0090), SOD2 (p = 0.0005), CAT (p = 0.0002), PINK1 (p = 0.0064), and p62 (p = 0.0228); followed by significant decreases in SIRT3 (p = 0.0003) and UCP2 (p = 0.0119) protein expression. Overall there were elevated levels of MDA (p = 0.0066) and decreased ATP production (p = 0.0017). In conclusion, ARVs induce mitochondrial stress and dysfunction, which may be closely associated with the progression of insulin resistance.
C1 [Mohan, Jivanka; Ghazi, Terisha; Sibiya, Thabani; Chuturgoon, Anil A. A.] Univ KwaZulu Natal, Sch Lab Med & Med Sci, Discipline Med Biochem, ZA-4041 Durban, South Africa.
C3 University of Kwazulu Natal
RP Ghazi, T; Chuturgoon, AA (corresponding author), Univ KwaZulu Natal, Sch Lab Med & Med Sci, Discipline Med Biochem, ZA-4041 Durban, South Africa.
EM ghazit@ukzn.ac.za; chutur@ukzn.ac.za
RI Ghazi, Terisha/AAU-5164-2021
OI Sibiya, Thabani/0000-0001-6648-2813; Ghazi, Terisha/0000-0002-0179-213X;
   Mohan, Jivanka/0000-0001-8446-5099
FU DAAD-NRF In-Country Master's and Doctoral Scholarships Programme [UID:
   128896]; National Research Foundation [120820]
FX This research was funded by DAAD-NRF In-Country Master's and Doctoral
   Scholarships Programme; Grant UID: 128896 and the National Research
   Foundation (120820).
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   World Health Organization, UPD REC FIRST 2 LIN
NR 47
TC 4
Z9 4
U1 0
U2 3
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2079-7737
J9 BIOLOGY-BASEL
JI Biology-Basel
PD APR
PY 2023
VL 12
IS 4
AR 580
DI 10.3390/biology12040580
PG 13
WC Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics
GA E7IS1
UT WOS:000977243400001
PM 37106780
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Zhou, SS
   Li, D
   Zhou, YM
   Cao, JM
AF Zhou, Shi-Sheng
   Li, Da
   Zhou, Yi-Ming
   Cao, Ji-Min
TI The skin function: a factor of anti-metabolic syndrome
SO DIABETOLOGY & METABOLIC SYNDROME
LA English
DT Review
DE The skin; Antioxidant defense; Xenobiotic; Lipid homeostasis; Sedentary
   lifestyle; Metabolic syndrome; Acanthosis nigricans; Acne
ID PERSISTENT ORGANIC POLLUTANTS; INORGANIC ARSENIC EXPOSURE;
   SERUM-CHOLESTEROL LEVELS; CORONARY-HEART-DISEASE; BODY-MASS INDEX;
   SEASONAL-VARIATION; OXIDATIVE STRESS; RISK-FACTORS; ACANTHOSIS
   NIGRICANS; INSULIN SENSITIVITY
AB The body's total antioxidant capacity represents a sum of the antioxidant capacity of various tissues/organs. A decrease in the body's antioxidant capacity may induce oxidative stress and subsequent metabolic syndrome, a clustering of risk factors for type 2 diabetes and cardiovascular disease. The skin, the largest organ of the body, is one of the major components of the body's total antioxidant defense system, primarily through its xenobiotic/drug biotransformation system, reactive oxygen species-scavenging system, and sweat glands-and sebaceous glands-mediated excretion system. Notably, unlike other contributors, the skin contribution is variable, depending on lifestyles and ambient temperature or seasonal variations. Emerging evidence suggests that decreased skin's antioxidant and excretory functions (e. g., due to sedentary lifestyles and low ambient temperature) may increase the risk for metabolic syndrome. This review focuses on the relationship between the variability of skin-mediated detoxification and elimination of exogenous and endogenous toxic substances and the development of metabolic syndrome. The potential role of sebum secretion in lipid and cholesterol homeostasis and its impact on metabolic syndrome, and the association between skin disorders (acanthosis nigricans, acne, and burn) and metabolic syndrome are also discussed.
C1 [Zhou, Shi-Sheng] Dalian Univ, Coll Med, Dept Physiol, Dalian 116622, Peoples R China.
   [Li, Da] China Med Univ, Dept Physiol, Shenyang 110001, Peoples R China.
   [Zhou, Yi-Ming] Natl Inst Nat Sci, Okazaki Inst Integrat Biosci, Sect Cell Signaling, Okazaki, Aichi 4448787, Japan.
   [Cao, Ji-Min] Chinese Acad Med Sci, Peking Union Med Coll, Sch Basic Med, Inst Basic Med Sci,Dept Physiol & Pathophysiol, Beijing 100005, Peoples R China.
C3 Dalian University; China Medical University; National Institutes of
   Natural Sciences (NINS) - Japan; Okazaki Institute for Integrative
   Bioscience (OIIB); Chinese Academy of Medical Sciences - Peking Union
   Medical College; Peking Union Medical College; Institute of Basic
   Medical Sciences - CAMS
RP Zhou, SS (corresponding author), Dalian Univ, Coll Med, Dept Physiol, Dalian 116622, Peoples R China.
EM zhouss@ymail.com
RI Zhou, Yiming/AAK-3059-2021
OI Zhou, Shi-Sheng/0000-0001-5156-3610
FU National Natural Science Foundation of China [31140036]; 973 program
   [2011CB503900]
FX This study was supported by National Natural Science Foundation of China
   (No. 31140036) and 973 program (2011CB503900).
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NR 118
TC 35
Z9 40
U1 3
U2 35
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1758-5996
J9 DIABETOL METAB SYNDR
JI Diabetol. Metab. Syndr.
PD APR 26
PY 2012
VL 4
AR 15
DI 10.1186/1758-5996-4-15
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 005KB
UT WOS:000308748200001
PM 22537765
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Papagianni, O
   Kaloteraki, C
   Kandyliari, A
   Potsaki, P
   Bousdouni, P
   Almpounioti, K
   Ouzaid, C
   Mavrou, AK
   Panteli, V
   Loukas, T
   Magkoutis, A
   Skalkos, D
   Karantonis, HC
   Koutelidakis, AE
AF Papagianni, Olga
   Kaloteraki, Chrysoula
   Kandyliari, Aikaterini
   Potsaki, Panagiota
   Bousdouni, Panorea
   Almpounioti, Kalliopi
   Ouzaid, Camille
   Mavrou, Anna-Kyriaki
   Panteli, Vasiliki
   Loukas, Thomas
   Magkoutis, Athanasios
   Skalkos, Dimitrios
   Karantonis, Haralabos C. C.
   Koutelidakis, Antonios E. E.
TI A Novel Functional Refined Olive Oil, Enhanced with Orange Peel Extract,
   Modulates Postprandial LDL-Cholesterol Responses in Individuals at
   Cardiometabolic Risk: A Pilot Randomized, Controlled, Cross-Over
   Nutritional Intervention
SO APPLIED SCIENCES-BASEL
LA English
DT Article
DE postprandial bioactivity; polyphenols; functional olive oil; orange peel
   extract; cardiometabolic risk
ID PHENOLIC-COMPOUNDS; LIPID PROFILE; POLYPHENOLS; HESPERIDIN; OXIDATION;
   FOOD; MEN
AB Olive oil, as the main source of polyphenols in the Mediterranean diet pattern, is mentioned to show remarkable postprandial bioactivity, contributing to the reduction of cardiometabolic risk factors. In recent years, the consumption of refined olive oil, instead of other olive oil classes, led to a reduced intake of polyphenols from the usual diet. This controlled, human nutritional intervention investigated whether the enhancement of refined olive oil with orange peel extract may modulate postprandial lipemia, glycemia, and oxidative stress in individuals at cardiometabolic risk. In a cross-over framework, 21 participants aged 30-65 years, who met the eligibility criteria, received a fat and carbohydrate meal of mashed potatoes, homogenized with refined olive oil (50 mL) or the functional olive oil, enhanced with 10% orange peel extract, intervening a washout week. Blood draws were performed in fasting, 30 min, 1.5 h, and 3 h after the meal intake. Plasma lipids, glucose, uric acid, and total plasma antioxidant capacity, according to the FRAP method, were measured at each timepoint. A significant reduction of LDL-cholesterol was observed, 1.5 h and 3 h after the functional meal intake, compared to non-significant changes after the control meal (p < 0.05). No other statistically significant interactions were detected to the remaining biomarkers (p > 0.05). Further investigation is needed for safer conclusions about the postprandial modulation of cardiometabolic risk factors by the functional olive oil enhanced with orange peel extract.
C1 [Papagianni, Olga; Kaloteraki, Chrysoula; Kandyliari, Aikaterini; Potsaki, Panagiota; Bousdouni, Panorea; Almpounioti, Kalliopi; Ouzaid, Camille; Mavrou, Anna-Kyriaki; Panteli, Vasiliki; Koutelidakis, Antonios E. E.] Univ Aegean, Food Sci & Nutr Dept, Human Nutr Unit, Lab Nutr & Publ Hlth, Myrina 81400, Greece.
   [Kandyliari, Aikaterini] Agr Univ Athens, Dept Food Sci & Human Nutr, Athens 11853, Greece.
   [Ouzaid, Camille] Inst Agro Dijon, Food Sci Dept, F-21000 Dijon, France.
   [Loukas, Thomas; Magkoutis, Athanasios] Outpatient Clin, Myrina 81400, Greece.
   [Skalkos, Dimitrios] Univ Ioannina, Dept Chem, Lab Food Chem, Ioannina 45110, Greece.
   [Karantonis, Haralabos C. C.] Univ Aegean, Food Sci & Nutr Dept, Lab Food Chem Biochem & Technol, Myrina 81400, Greece.
C3 Agricultural University of Athens; Institut Agro; University of Ioannina
RP Koutelidakis, AE (corresponding author), Univ Aegean, Food Sci & Nutr Dept, Human Nutr Unit, Lab Nutr & Publ Hlth, Myrina 81400, Greece.
EM akoutel@aegean.gr
RI Papagianni, Olga/KIE-3020-2024; SKALKOS, DIMITRIS/AIB-6019-2022
OI KARANTONIS, HARALABOS/0000-0003-1134-7811; Kaloteraki,
   chrysoula/0000-0002-4195-2329; Kandyliari,
   Aikaterini/0000-0002-0883-7409; Bousdouni, Panoraia/0000-0001-9760-1483;
   SKALKOS, DIMTRIS/0000-0002-7771-2845; Papagianni,
   Olga/0000-0003-0026-0630; Almpounioti, Kalliopi/0009-0009-4864-4837;
   KOUTELIDAKIS, ANTONIOS/0000-0001-5137-0499
CR Akiyama S, 2009, BIOSCI BIOTECH BIOCH, V73, P2779, DOI 10.1271/bbb.90576
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NR 38
TC 0
Z9 0
U1 1
U2 4
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2076-3417
J9 APPL SCI-BASEL
JI Appl. Sci.-Basel
PD AUG
PY 2023
VL 13
IS 15
AR 8574
DI 10.3390/app13158574
PG 14
WC Chemistry, Multidisciplinary; Engineering, Multidisciplinary; Materials
   Science, Multidisciplinary; Physics, Applied
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Engineering; Materials Science; Physics
GA O7CY4
UT WOS:001045357200001
OA gold, Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Benjamin, JJ
   MaheshKumar, K
   Koshy, T
   Maruthy, KN
   Padmavathi, R
AF Benjamin, Jiby Jolly
   MaheshKumar, K.
   Koshy, Teena
   Maruthy, K. N.
   Padmavathi, R.
TI DHEA and polycystic ovarian syndrome: Meta-analysis of case-control
   studies
SO PLOS ONE
LA English
DT Article
ID GLUCOSE-TOLERANCE TEST; QUALITY-OF-LIFE; MASS-SPECTROMETRY; ANDROGEN
   RESPONSE; DEXAMETHASONE-SUPPRESSION; WOMEN; HIRSUTISM; PCOS;
   HYPERANDROGENISM; STEROIDOGENESIS
AB Background
   Polycystic ovarian syndrome is a heterogenous endocrine disorder characterized by irregular menstrual cycles, hirsuitism and polycystic ovaries. It is further complicated by metabolic syndrome, infertility and psychological stress. Although the etiopathogenesis is unclear, many studies have pointed out the role of stress in this syndrome. DHEA, being a stress marker is being used by scientists to compare the stress levels between polycystic ovarian cases and healthy controls. However, the results obtained from previous studies are equivocal.
   Objective
   To perform meta-analysis and find the association between stress and the syndrome.
   Data sources
   Relevant data till January 2021 were retrieved from PubMed, Scopus, Embase and Web of Science using MeSH terms.
   Study selection
   Case-control studies having PCOS subjects as cases and healthy women as controls were selected provided; their basal DHEA levels were mentioned in the published articles.
   Data extraction
   Two authors independently extracted the articles and qualified the final studies.
   Data synthesi
   Pooled meta-analysis was done using random effect model and showed level of DHEA statistically significant in PCOS compared to healthy controls (SMD = 1.15, 95% CI = 0.59-1.71).Heterogeneity was statistically significant as well (I-2 = 95%).
   Conclusion
   This meta-analysis on DHEA and PCOS has helped in generating evidence regarding the involvement of stress in the pathogenesis of PCOS.
C1 [Benjamin, Jiby Jolly; Padmavathi, R.] Sri Ramachandra Inst Higher Educ & Res, Sri Ramachandra Med Coll & Res Inst, Dept Physiol, Chennai, Tamil Nadu, India.
   [MaheshKumar, K.] Govt Yoga & Naturopathy Med Coll & Hosp, Dept Physiol, Chennai, Tamil Nadu, India.
   [Koshy, Teena] Sri Ramachandra Inst Higher Educ & Res, Dept Human Genet, Chennai, Tamil Nadu, India.
   [Maruthy, K. N.] Narayana Med Coll & Hosp, Dept Physiol, Nellore, Andra Pradesh, India.
C3 Sri Ramachandra Institute of Higher Education & Research; Sri
   Ramachandra Institute of Higher Education & Research
RP Padmavathi, R (corresponding author), Sri Ramachandra Inst Higher Educ & Res, Sri Ramachandra Med Coll & Res Inst, Dept Physiol, Chennai, Tamil Nadu, India.
EM rpadmavathi@sriramachandra.edu.in
RI K, Maheshkumar/N-7147-2018
OI K, Maheshkumar/0000-0002-5377-7847; Koshy, Teena/0000-0001-5193-1436
FU ICMR under TSS scheme [U04M180048]
FX The first author Benjamin Jiby received financial support from ICMR
   under TSS scheme (No: U04M180048).
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NR 55
TC 9
Z9 9
U1 0
U2 6
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD DEC 21
PY 2021
VL 16
IS 12
AR e0261552
DI 10.1371/journal.pone.0261552
PG 13
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 0X1HA
UT WOS:000789464700039
PM 34932604
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Kim-Dorner, SJ
   Simpson-McKenzie, CO
   Poth, M
   Deuster, PA
AF Kim-Dorner, Su-Jong
   Simpson-McKenzie, Christie O.
   Poth, Merrily
   Deuster, Patricia A.
TI PSYCHOLOGICAL AND PHYSIOLOGICAL CORRELATES OF INSULIN RESISTANCE AT
   FASTING AND IN RESPONSE TO A MEAL IN AFRICAN AMERICANS AND WHITES
SO ETHNICITY & DISEASE
LA English
DT Article
DE Insulin Resistance; Stress; Ethnicity; Coping Style
ID IMPAIRED GLUCOSE-TOLERANCE; METABOLIC SYNDROME; DIABETES-MELLITUS;
   WEIGHT; WOMEN; FAT; POPULATION; STRESS; MODEL; RISK
AB Background: African Americans are more insulin resistant than are Whites. The purpose of this study was to characterize physiologic and psychological (stress coping style) correlates of insulin resistance in African Americans and Whites.
   Methods: We examined African American (n = 67) and White (n = 41) men and women aged 18-45 years with body mass index 1835 kg/m(2). We used the homeostasis model assessment (HOMA-IR) and area under the curve for insulin (AUC) after a standardized meal as measure of insulin resistance. We obtained anthropometric measures and determined maximal aerobic power (VO2max) by treadmill exercise. We used stress profile to assess stress and coping style.
   Results: Postprandial insulin AUCs were higher in African Americans than in Whites. Anthropometric measures and VO2max were related to HOMA-IR and AUC. Although self-reported stress level did not differ between Whites and African Americans, positive appraisal predicted reduced HOMA-IR and negative appraisal coping style predicted increased insulin AUC.
   Conclusions: Psychosocial factors may be determinants of health and targets of intervention for obesity-related disorders such as insulin resistance. Existing behavioral intervention programs, designed with a sole emphasis on exercise and nutrition, may fall short of optimal effectiveness. (Ethn Dis. 2009;19:104-110)
C1 [Kim-Dorner, Su-Jong; Simpson-McKenzie, Christie O.] Uniformed Serv Univ Hlth Sci, Dept Med & Clin Psychol, Bethesda, MD 20814 USA.
   [Poth, Merrily] Uniformed Serv Univ Hlth Sci, Dept Pediat, Bethesda, MD 20814 USA.
C3 Uniformed Services University of the Health Sciences - USA; Uniformed
   Services University of the Health Sciences - USA
RP Kim-Dorner, SJ (corresponding author), Uniformed Serv Univ Hlth Sci, Dept Med & Clin Psychol, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA.
EM sjkim@usuhs.mil
RI Deuster, Patricia/G-3838-2015
OI Deuster, Patricia/0000-0002-7895-0888; Kim-Dorner,
   Su-Jong/0000-0003-3927-7333
FU US Army Medical Research and Material Command Award [DAMD17-03-20024]
FX The study was supported by the US Army Medical Research and Material
   Command Award number DAMD17-03-20024.
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NR 28
TC 4
Z9 6
U1 0
U2 3
PU INT SOC HYPERTENSION BLACKS-ISHIB
PI ATLANTA
PA 100 AUBURN AVE NE STE 401, ATLANTA, GA 30303-2527 USA
SN 1049-510X
EI 1945-0826
J9 ETHNIC DIS
JI Ethn. Dis.
PD SPR
PY 2009
VL 19
IS 2
BP 104
EP 110
PG 7
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA 455OB
UT WOS:000266769300002
PM 19537218
DA 2025-06-11
ER

PT J
AU Soligo, M
   Morlacco, A
   Zattoni, F
   Valotto, C
   De Giorgi, G
   Beltrami, P
AF Soligo, Matteo
   Morlacco, Alessandro
   Zattoni, Fabio
   Valotto, Claudio
   De Giorgi, Gioacchino
   Beltrami, Paolo
TI Metabolic syndrome and stone disease
SO PANMINERVA MEDICA
LA English
DT Review
DE Metabolic syndrome; Kidney calculi; Diabetes mellitus; Obesity;
   Hypertension
ID BODY-MASS INDEX; URIC-ACID NEPHROLITHIASIS; INCIDENT KIDNEY-STONES;
   INSULIN-RESISTANCE; LIPID NEPHROTOXICITY; INCREASED PREVALENCE;
   URINARY-EXCRETION; HYPERTENSIVE-RATS; RISK; CALCIUM
AB Metabolic syndrome (MetS) is a clustering of several pathological medical conditions including hypertension. impaired glucose tolerance. diabetes, abdominal obesity and dyslipidemia. In the last two decades, MetS has reached an epidemic stage, with an estimated prevalence in the range of 30% among the American adult population and a constant increase for all age categories. The incidence of nephrolithiasis between different geographical areas, ranging 1% to 13%; however, a worldwide increase has been recently reported. There is consistent evidence in the literature both about the association between metabolic syndrome./metabolic syndrome traits and kidney stones. Conversely, less is known about the underlying mechanisms and the complex interplay between metabolic syndrome traits. In this work, we sought to review the literature and to summarize the available evidence regarding the association between metabolic syndrome and nephrolithiasis, the biological mechanisms linking metabolic syndrome and its trait to stone formation, and stone composition in individuals affected by metabolic syndrome. In conclusion, we would like to stress the concept of "appropriate" dietary habits and lifestyle as a key concept in the prevention of both metabolic syndrome and nephrolithiasis.
C1 [Soligo, Matteo; Zattoni, Fabio; Valotto, Claudio; De Giorgi, Gioacchino] Santa Maria Misericordia Acad Med Ctr, Urol Clin, Piazzale Santa Maria Misericordia 15, I-33100 Udine, Italy.
   [Morlacco, Alessandro; Beltrami, Paolo] Univ Padua, Urol Clin, Dept Surg Oncol & Gastroenterol, Padua, Italy.
C3 University of Padua
RP Soligo, M (corresponding author), Santa Maria Misericordia Acad Med Ctr, Urol Clin, Piazzale Santa Maria Misericordia 15, I-33100 Udine, Italy.
EM matteo.soligo@asufc.sanita.fvg.it
RI Zattoni, Fabio/V-7753-2019
OI Zattoni, Fabio/0000-0002-4178-373X
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NR 100
TC 19
Z9 20
U1 2
U2 18
PU EDIZIONI MINERVA MEDICA
PI TURIN
PA CORSO BRAMANTE 83-85 INT JOURNALS DEPT., 10126 TURIN, ITALY
SN 0031-0808
EI 1827-1898
J9 PANMINERVA MED
JI Panminerva Medica
PD SEP
PY 2022
VL 64
IS 3
BP 344
EP 358
DI 10.23736/S0031-0808.21.04517-1
PG 15
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 7A8CC
UT WOS:000898676200005
PM 34609121
DA 2025-06-11
ER

PT J
AU Baliño, P
   Romero-Cano, R
   Muriach, M
AF Balino, Pablo
   Romero-Cano, Ricard
   Muriach, Maria
TI Biochemical and Behavioral Consequences of Ethanol Intake in a Mouse
   Model of Metabolic Syndrome
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE ethanol; diabetes; metabolic syndrome; oxidative stress; mice
ID GLUTATHIONE-PEROXIDASE-ACTIVITY; TYPE-2 DIABETES-MELLITUS; OXIDATIVE
   STRESS; ALCOHOL-CONSUMPTION; LIPID-PEROXIDATION; ANTIOXIDANT STATUS;
   GLYCEMIC CONTROL; DNA-DAMAGE; RISK; GLUCOSE
AB Ethanol abuse is a common issue in individuals with sedentary lifestyles, unbalanced diets, and metabolic syndrome. Both ethanol abuse and metabolic syndrome have negative impacts on the central nervous system, with effects including cognitive impairment and brain oxidative status deterioration. The combined effects of ethanol abuse and metabolic syndrome at a central level have not yet been elucidated in detail. Thus, this work aims to determine the effects of ethanol intake on a mouse model of metabolic syndrome at the behavioral and biochemical levels. Seven-week-old male control (B6.V-Lep ob/+JRj) and leptin-deficient (metabolic syndrome) (B6.V-Lep ob/obJRj) mice were used in the study. Animals were divided into four groups: control, ethanol, obese, and obese-ethanol. Ethanol consumption was monitored for 6 weeks. Basal glycemia, insulin, and glucose overload tests were performed. To assess short- and long-term memory, an object recognition test was used. In order to assess oxidative status in mouse brain samples, antioxidant enzyme activity was analyzed with regard to glutathione peroxidase, glutathione reductase, glutathione, glutathione disulfide, lipid peroxidation products, and malondialdehyde. Ethanol intake modulated the insulin response and impaired the oxidative status in the ob mouse brain.
C1 [Balino, Pablo; Romero-Cano, Ricard; Muriach, Maria] Univ Jaume 1, Unitat Predept Med, Castellon de La Plana 12071, Spain.
C3 Universitat Jaume I
RP Muriach, M (corresponding author), Univ Jaume 1, Unitat Predept Med, Castellon de La Plana 12071, Spain.
EM balino@uji.es; romeror@uji.es; muriach@uji.es
RI Muriach, María/AAB-2003-2019; Balino, Pablo/L-1643-2017
OI Romero Cano, Ricard/0000-0003-2672-2346; Balino,
   Pablo/0000-0002-6271-3466
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NR 76
TC 4
Z9 4
U1 3
U2 12
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD JAN
PY 2021
VL 22
IS 2
AR 807
DI 10.3390/ijms22020807
PG 14
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA PX4HL
UT WOS:000611317600001
PM 33467410
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Lee, Y
   Kim, M
   Choi, K
   Kim, J
   Bae, W
   Kim, S
   Sohn, C
AF Lee, Yesong
   Kim, Misung
   Choi, Kyungsuk
   Kim, Juyong
   Bae, Wookyung
   Kim, Sohye
   Sohn, Cheongmin
TI Relationship between inflammation biomarkers, antioxidant vitamins, and
   bone mineral density in patients with metabolic syndrome
SO NUTRITION RESEARCH AND PRACTICE
LA English
DT Article
DE BMD; inflammation; antioxidant; metabolic syndrome; gender
ID C-REACTIVE PROTEIN; POSTMENOPAUSAL WOMEN; ADIPONECTIN; PREMENOPAUSAL;
   INTERLEUKIN-6; ASSOCIATION; PREDICTOR; MORTALITY; DISEASE; STRESS
AB Few studies have shown the correlation between metabolic syndrome and bone mineral density (BMD). The main pathogenic mechanisms of metabolic syndrome rely on chronic low-level inflammatory status and oxidative stress. There are few studies that examine the gender-specific effects of inflammation and antioxidants on BMD. In this study, we evaluated the relative contribution of these factors in patients with metabolic syndrome. We conducted a cross-sectional study of 67 men and 46 postmenopausal women with metabolic syndrome; metabolic syndrome was defined as having three or more metabolic syndrome risk factors. BMD, body fat mass, and lean body mass were evaluated. We also examined the levels of high sensitive C-reactive protein (hs-CRP), interleukin-6 (IL-6), adiponectin, vitamin E, and C in serum. Log-transformed hs-CRP levels were significantly higher in lumbar spine osteoporotic subjects than in normal subjects for women but not for men. There was no significant difference between the normal group and the osteoporotic group in other inflammatory markers. Stepwise regression analyses for BMD of the lumbar spine showed that lean body mass and vitamin E were significant determinants in men. Lean body mass and log-transformed hs-CRP were significant determinants in women Analysis for BMD of the femoral neck showed that lean body mass was a significant determinant for both men and women. There was no significant factor among the inflammatory markers or antioxidant vitamins affecting the femoral neck BMD for either gender. In conclusion, while hs-CRP is an independent predictor of the BMD of the lumbar spine in women, vitamin E showed profound effects on BMD in men but not women with metabolic syndrome.
C1 [Lee, Yesong; Kim, Misung; Sohn, Cheongmin] Wonkwang Univ, Iksan 570749, Jeonbuk, South Korea.
   [Choi, Kyungsuk] Daejin Univ, Dept Food Sci & Nutr, Pochon 487711, South Korea.
   [Kim, Juyong; Bae, Wookyung; Kim, Sohye] Seoul Natl Univ, Bundang Hosp, Hlth Promot Ctr, Songnam 463707, South Korea.
C3 Wonkwang University; Daejin University; Seoul National University (SNU)
RP Sohn, C (corresponding author), Wonkwang Univ, Iksan 570749, Jeonbuk, South Korea.
EM ccha@wku.ac.kr
RI Kim, Kyung-Hee/JBI-8300-2023; Choi, KyungSuk/HKO-6080-2023
OI Sohn, Cheongmin/0000-0003-0529-7037
FU National Research Foundation of Korea [2010-0015498]
FX This work was supported in part by a grant from National Research
   Foundation of Korea (2010-0015498).
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NR 41
TC 15
Z9 18
U1 1
U2 7
PU KOREAN NUTRITION SOC
PI SEOUL
PA 804 KST CTR, 635-4 YEOGSAM-SONG KANGNAM-KU, SEOUL, 135-703, SOUTH KOREA
SN 1976-1457
EI 2005-6168
J9 NUTR RES PRACT
JI Nutr. Res. Pract.
PD APR
PY 2011
VL 5
IS 2
BP 150
EP 156
DI 10.4162/nrp.2011.5.2.150
PG 7
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 760YV
UT WOS:000290362200009
PM 21556229
OA Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Andres-Hernando, A
   Orlicky, DJ
   Cicerchi, C
   Kuwabara, M
   Garcia, GE
   Nakagawa, T
   Sanchez-Lozada, LG
   Johnson, RJ
   Lanaspa, MA
AF Andres-Hernando, Ana
   Orlicky, David J.
   Cicerchi, Christina
   Kuwabara, Masanari
   Garcia, Gabriela E.
   Nakagawa, Takahiko
   Sanchez-Lozada, Laura Gabriela
   Johnson, Richard J.
   Lanaspa, Miguel A.
TI High Fructose Corn Syrup Accelerates Kidney Disease and Mortality in
   Obese Mice with Metabolic Syndrome
SO BIOMOLECULES
LA English
DT Article
DE metabolic syndrome; obesity; chronic kidney disease; fructose; high
   fructose corn syrup
ID URIC-ACID; FRUCTOKINASE; LEPTIN; SUGAR; ASSOCIATION; EXPRESSION; INJURY;
   LIVER; RATS
AB The presence of obesity and metabolic syndrome is strongly linked with chronic kidney disease (CKD), but the mechanisms responsible for the association are poorly understood. Here, we tested the hypothesis that mice with obesity and metabolic syndrome might have increased susceptibility to CKD from liquid high fructose corn syrup (HFCS) by favoring the absorption and utilization of fructose. We evaluated the pound mouse model of metabolic syndrome to determine if it showed baseline differences in fructose transport and metabolism and whether it was more susceptible to chronic kidney disease when administered HFCS. Pound mice have increased expression of fructose transporter (Glut5) and fructokinase (the limiting enzyme driving fructose metabolism) associated with enhanced fructose absorption. Pound mice receiving HFCS rapidly develop CKD with increased mortality rates associated with intrarenal mitochondria loss and oxidative stress. In pound mice lacking fructokinase, the effect of HFCS to cause CKD and early mortality was aborted, associated with reductions in oxidative stress and fewer mitochondria loss. Obesity and metabolic syndrome show increased susceptibility to fructose-containing sugars and increased risk for CKD and mortality. Lowering added sugar intake may be beneficial in reducing the risk for CKD in subjects with metabolic syndrome.
C1 [Andres-Hernando, Ana; Cicerchi, Christina; Garcia, Gabriela E.; Lanaspa, Miguel A.] Univ Colorado, Div Endocrinol Metab & Diabet, Anschutz Med Campus, Aurora, CO 80045 USA.
   [Andres-Hernando, Ana; Lanaspa, Miguel A.] Rocky Mt VA Med Ctr, Div Nephrol, Aurora, CO 80045 USA.
   [Orlicky, David J.; Johnson, Richard J.] Univ Colorado, Dept Pathol, Anschutz Med Campus, Aurora, CO 80045 USA.
   [Kuwabara, Masanari] Toranomon Gen Hosp, Div Cardiovasc Dis, Tokyo 1058470, Japan.
   [Garcia, Gabriela E.; Johnson, Richard J.] Univ Colorado, Div Renal Dis & Hypertens, Anschutz Med Campus, Aurora, CO 80045 USA.
   [Nakagawa, Takahiko] Shiga Univ Med Sci, Dept Regenerat Med Dev, Seta Tsukinowa cho, Otsu 5202192, Japan.
   [Sanchez-Lozada, Laura Gabriela] INC Ignacio Chavez, Dept Cardiorenal Physiopathol, Mexico City 14080, Mexico.
C3 University of Colorado System; University of Colorado Anschutz Medical
   Campus; University of Colorado System; University of Colorado Anschutz
   Medical Campus; Toranomon Hospital; University of Colorado System;
   University of Colorado Anschutz Medical Campus; Shiga University of
   Medical Science
RP Lanaspa, MA (corresponding author), Univ Colorado, Div Endocrinol Metab & Diabet, Anschutz Med Campus, Aurora, CO 80045 USA.; Lanaspa, MA (corresponding author), Rocky Mt VA Med Ctr, Div Nephrol, Aurora, CO 80045 USA.
EM miguel.lanaspagarcia@cuanschutz.edu
RI Lanaspa, Miguel/AAO-4971-2020; Sanchez-Lozada, Laura/AAS-2104-2021;
   Kuwabara, Masanari/O-9844-2017
OI Orlicky, David/0000-0002-0417-1400; Andres-Hernando,
   Ana/0000-0002-0676-0188; Johnson, Richard/0000-0003-3312-8193;
   Sanchez-Lozada, Laura-Gabriela/0000-0003-0348-9617; Kuwabara,
   Masanari/0000-0002-6601-4347
FU VA Merit [BXI01BX004511]; NIH [R01 DK121496]
FX Supported by VA Merit BXI01BX004511 (Johnson) and NIH R01 DK121496
   (Lanaspa).
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NR 40
TC 9
Z9 9
U1 0
U2 13
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2218-273X
J9 BIOMOLECULES
JI Biomolecules
PD APR 30
PY 2023
VL 13
IS 5
AR 780
DI 10.3390/biom13050780
PG 17
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA H4GX3
UT WOS:000995576500001
PM 37238651
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Fond, G
   Godin, O
   Brunel, L
   Aouizerate, B
   Berna, F
   Bulzacka, E
   Capdevielle, D
   Chereau, I
   Dorey, JM
   Dubertret, C
   Dubreucq, J
   Faget, C
   Gabayet, F
   Le Strat, Y
   Micoulaud-Franchi, JA
   Misdrahi, D
   Rey, R
   Richieri, R
   Passerieux, C
   Schandrin, A
   Schürhoff, F
   Tronche, AM
   Urbach, M
   Vidalhet, P
   Llorca, PM
   Leboyer, M
AF Fond, G.
   Godin, O.
   Brunel, L.
   Aouizerate, B.
   Berna, F.
   Bulzacka, E.
   Capdevielle, D.
   Chereau, I.
   Dorey, J. M.
   Dubertret, C.
   Dubreucq, J.
   Faget, C.
   Gabayet, F.
   Le Strat, Y.
   Micoulaud-Franchi, J. A.
   Misdrahi, D.
   Rey, R.
   Richieri, R.
   Passerieux, C.
   Schandrin, A.
   Schuerhoff, F.
   Tronche, A. M.
   Urbach, M.
   Vidalhet, P.
   Llorca, P. M.
   Leboyer, M.
CA FACE-SZ FondaMental Acad Ctr
TI Peripheral sub-inflammation is associated with antidepressant
   consumption in schizophrenia. Results from the multi-center FACE-SZ data
   set
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE C-reactive protein (CRP); Schizophrenia; Depression; Antidepressant;
   Metabolic syndrome; Abdominal obesity
ID C-REACTIVE PROTEIN; METABOLIC SYNDROME; COGNITIVE IMPAIRMENT; ABDOMINAL
   OBESITY; BIPOLAR DISORDER; MAJOR DEPRESSION; MENTAL-DISORDERS;
   ADIPOSE-TISSUE; METAANALYSIS; CYTOKINES
AB Objectives: The relation between C-Reactive Protein (CRP), depression and antidepressant consumption has been well explored in major depressive disorders but not in schizophrenia, which has a high rate of depression comorbidity. The objectives of this study were: (i) to determine the prevalence of abnormal CRP levels, depression and antidepressant consumption in a multicenter community-dwelling sample of subjects with schizophrenia (ii) to determine the association between abnormal CRP levels, depression and antidepressant consumption in schizophrenia.
   Method: 219 stable patients with schizophrenia (mean age=31.6 years, 75.3% male gender) were systematically included in the multicentre network of FondaMental Expert Center for schizophrenia (FACESZ) and assessed with a dedicated electronic medical record including the Structured Clinical Interview for DSM-IV Axis I Disorders and Calgary Depression Scale for depression. High sensitivity CRP (hs-CRP) was measured with an assay using nephelometry (Dade Behring). Abnormal CRP level was defined by levels > 3 mg/L. Current medication was recorded.
   Results: Overall, 63 subjects (28.8%) were found to have abnormal CRP levels, 43 (20.1%) received a diagnosis of comorbid current depression, and 51 (31.9%) had ongoing antidepressant treatment. In univariate analysis, abnormal CRP levels were found to be significantly associated with body mass index (BMI) (p < 0.0001), hypertriglyceridemia (p =0.0015), high waist circumference (p < 0.0001), metabolic syndrome (p= 0.0011), abdominal obesity (p < 0.0001) and with antidepressant consumption (p= 0.01), while depression, psychotic symptomatology, age of onset, illness duration, sociodemographic characteristics, current tobacco or cannabis status, hypertension or high fasting glucose were not (all p > 0.05).
   In a multivariate model, abnormal CRP was associated with antidepressant consumption independently of other confounding variables (adjusted Odds Ratio =2.8, 95% confidence interval 1.226.62). Metabolic syndrome was also independently associated with abnormal CRP (adjusted Odds Ratio = 2.6, 95% confidence interval 1.01-6.71).
   Conclusion: Abnormal CRP levels in schizophrenia were found to be associated with antidepressant consumption, but not with depression. The potential mechanisms were discussed. Antidepressant consumption should be systematically recorded in future studies exploring inflammation in schizophrenia. Future clinical trials of interventions directed at lowering the level of CRP and other inflammatory markers are discussed. (c) 2015 Elsevier BY. All rights reserved.
C1 [Fond, G.; Godin, O.; Brunel, L.; Aouizerate, B.; Berna, F.; Bulzacka, E.; Capdevielle, D.; Chereau, I.; Dorey, J. M.; Dubertret, C.; Dubreucq, J.; Faget, C.; Gabayet, F.; Le Strat, Y.; Misdrahi, D.; Rey, R.; Richieri, R.; Passerieux, C.; Schandrin, A.; Schuerhoff, F.; Tronche, A. M.; Urbach, M.; Llorca, P. M.; Leboyer, M.] Fdn FondaMental, Creteil, France.
   [Fond, G.; Brunel, L.; Bulzacka, E.; Schuerhoff, F.; Leboyer, M.] INSERM U955, Translat Psychiat Team, Creteil, France.
   [Fond, G.; Brunel, L.; Bulzacka, E.; Schuerhoff, F.; Leboyer, M.] Paris Est Univ, DHU Pe PSY, Pole Psychiat Hop Univ H Mondor, Creteil, France.
   [Godin, O.] Univ Paris 06, Sorbonne Univ, UMR S 1136, Inst Pierre Louis Epidemiol & Sante Publ,INSERM, F-75013 Paris, France.
   [Aouizerate, B.; Misdrahi, D.] Univ Bordeaux, Ctr Hosp Charles Perrens, F-33076 Bordeaux, France.
   [Berna, F.; Vidalhet, P.] Univ Strasbourg, Hop Univ Strasbourg, INSERM U1114, Federat Med Translat Strasbourg, Strasbourg, France.
   [Capdevielle, D.; Schandrin, A.] Univ Montpellier I, CHRU Montpellier, Hop Colombiere, Serv Univ Psychiat Adulte,Inserm 1061, Montpellier, France.
   [Chereau, I.; Tronche, A. M.; Llorca, P. M.] Univ Auvergne, CMP B, CHU, EA Fac Med 7280, F-63003 Clermont Ferrand 1, France.
   [Dorey, J. M.; Rey, R.] Univ Lyon 1, Ctr Hosp Le Vinatier Pole Est, F-69678 Bron, France.
   [Dubertret, C.; Le Strat, Y.] Univ Paris Diderot, Sorbonne Paris Cite, Louis Mourier Hosp, AP HP,Dept Psychiat,Inserm U894,Fac Med, Colombes, France.
   [Dubreucq, J.; Gabayet, F.] CH Alpes Isere, Ctr Referent Rehabil Psychosociale, Grenoble, France.
   [Faget, C.; Richieri, R.] Pole Univ Psychiat, AP HM, Marseille, France.
   [Passerieux, C.; Urbach, M.] Univ Versailles St Quentin Yvelines, Ctr Hosp Versailles, Serv Psychiat Adulte, UFR Sci Sante Simone Veil, Versailles, France.
   [Micoulaud-Franchi, J. A.] Bordeaux Univ, Bordeaux Sleep Clin, Pellegrin Univ Hosp, USR CNRS SANPSY 3413,Res Unit, F-33000 Bordeaux, France.
   [Aouizerate, B.] INSERM, Neuroctr Magendie, Physiopathol Plast Neuronale, U862, F-33000 Bordeaux, France.
   [Misdrahi, D.] CNRS UMR 5287 INCIA, Paris, France.
C3 Universite Paris-Est-Creteil-Val-de-Marne (UPEC); Institut National de
   la Sante et de la Recherche Medicale (Inserm); Assistance Publique
   Hopitaux Paris (APHP); Universite Paris-Est-Creteil-Val-de-Marne (UPEC);
   Hopital Universitaire Henri-Mondor - APHP; Sorbonne Universite; Institut
   National de la Sante et de la Recherche Medicale (Inserm); Universite de
   Bordeaux; Institut National de la Sante et de la Recherche Medicale
   (Inserm); CHU Strasbourg; Universites de Strasbourg Etablissements
   Associes; Universite de Strasbourg; Universite de Montpellier; CHU de
   Montpellier; Institut National de la Sante et de la Recherche Medicale
   (Inserm); Universite Clermont Auvergne (UCA); CHU Clermont Ferrand;
   Universite Claude Bernard Lyon 1; Universite Paris Cite; Institut
   National de la Sante et de la Recherche Medicale (Inserm); Assistance
   Publique Hopitaux Paris (APHP); Hopital Universitaire Louis-Mourier -
   APHP; Aix-Marseille Universite; Assistance Publique-Hopitaux de
   Marseille; Universite Paris Saclay; Centre Hospitalier de Versailles;
   Centre National de la Recherche Scientifique (CNRS); CNRS - National
   Institute for Biology (INSB); Universite de Bordeaux; CHU Bordeaux;
   Institut National de la Sante et de la Recherche Medicale (Inserm);
   Universite de Bordeaux; Centre National de la Recherche Scientifique
   (CNRS); CNRS - National Institute for Biology (INSB)
RP Fond, G (corresponding author), Fdn FondaMental, Creteil, France.
RI Leboyer, Marion/AAW-3648-2021; Capdevielle, Delphine/HTO-4229-2023;
   JeanMichel, Dorey/KHZ-0906-2024; richieri, raphaelle/E-4707-2015;
   Schandrin, Aurélie/ISV-4608-2023; Berna, Fabrice/J-2701-2019; Le Strat,
   Yann/C-9848-2013; TESSIER, Arnaud/A-4022-2017; FOND,
   Guillaume/D-7646-2011
OI MICOULAUD-FRANCHI, Jean-Arthur/0000-0002-5203-8444; D'Amato,
   Thierry/0000-0001-8983-0315; TESSIER, Arnaud/0000-0001-5758-5693; FOND,
   Guillaume/0000-0003-3249-2030; Misdrahi, David/0000-0003-1146-3206;
   Aouizerate, Bruno/0000-0002-7092-7747; RICHIERI,
   Raphaelle/0000-0002-3901-7016; DANION, Jean-Marie/0000-0002-1980-1006;
   REY, Romain/0000-0002-4603-3575; Capdevielle,
   Delphine/0000-0002-7146-8554; dubreucq, julien/0000-0003-4079-4194;
   Berna, Fabrice/0000-0002-6118-0629; VIDAILHET,
   Pierre/0000-0002-3139-639X; LEBOYER, Marion/0000-0001-5473-3697
FU AP-HP (Assistance Publique des Hopitaux de Paris); Fondation FondaMental
   (RTRS Sante Mentale); Investissements d'Avenir program
   [ANR-11-IDEX-0004-02, ANR-10-COHO-10-01]; INSERM (Institut National de
   la Sante et de la Recherche Medicale)
FX This work was funded by AP-HP (Assistance Publique des Hopitaux de
   Paris), Fondation FondaMental (RTRS Sante Mentale), by the
   Investissements d'Avenir program managed by the ANR under reference
   ANR-11-IDEX-0004-02 and ANR-10-COHO-10-01, and by INSERM (Institut
   National de la Sante et de la Recherche Medicale). We express all our
   thanks to the nurses, and to the patients who were included in the
   present study.
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NR 55
TC 31
Z9 31
U1 0
U2 20
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD FEB
PY 2016
VL 191
BP 209
EP 215
DI 10.1016/j.jad.2015.11.017
PG 7
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA DB1FL
UT WOS:000368253400027
PM 26674214
DA 2025-06-11
ER

PT J
AU Ercan, H
   Kiyici, A
   Marakoglu, K
   Oncel, M
AF Ercan, Humeyra
   Kiyici, Aysel
   Marakoglu, Kamile
   Oncel, Mufide
TI 8-Isoprostane and Coenzyme Q10 Levels in Patients with Metabolic
   Syndrome
SO METABOLIC SYNDROME AND RELATED DISORDERS
LA English
DT Article
ID SYSTEMIC OXIDATIVE STRESS
AB Background: Metabolic syndrome has become an important health problem, which involves obesity, hyper-lipidemia, insulin resistance, and high blood pressure values. The components of metabolic syndrome are all suggested as independent cardiovascular disease risk factors along with high mortality and morbidity rates accompanied by many organ and system complications.
   Objective: We aimed to determine 8-isoprostane (8-IsoP) and coenzyme Q10 (CoQ10) levels in patients with metabolic syndrome and healthy individuals and demonstrate whether there was any relation between these parameters and metabolic syndrome criteria.
   Materials and Methods: A total of 30 patients (10 male, 20 female) with metabolic syndrome and 20 age-matched healthy individuals (9 male, 11 female) were involved in the study. Body mass index, waist and hip circumferences, systolic and diastolic blood pressures and serum glucose, triglyceride, total cholesterol, high-density lipoprotein cholesterol, insulin, HbA1c, 8-IsoP and CoQ10 levels, and homeostasis model assessment of insulin resistance indexes of all participants were determined.
   Results: 8-IsoP levels were significantly increased in metabolic syndrome compared to healthy individuals (P = 0.003), however, there was no significant difference between groups for CoQ10 levels. 8-IsoP levels were positively correlated with waist circumference (r = 0.303, P=0.032), diastolic blood pressure (r = 0.337, P = 0.017), systolic blood pressure (r = 0.329, P = 0.020) values and total cholesterol levels (r = 0.354, P=0.012).
   Conclusion: We can suggest that the levels of 8-IsoP, which is an indicator of the oxidative stress, increase in metabolic syndrome and this can be associated with high blood pressure and visceral adiposity, which are the components of metabolic syndrome.
C1 [Ercan, Humeyra] Necmettin Erbakan Univ, Meram Med Fac, Dept Biochem, Konya, Turkey.
   [Kiyici, Aysel; Oncel, Mufide] Mevlana Univ, Fac Med, Dept Biochem, Konya, Turkey.
   [Marakoglu, Kamile] Selcuk Univ, Dept Family Med, Konya, Turkey.
C3 Necmettin Erbakan University; Mevlana University; Selcuk University
RP Kiyici, A (corresponding author), Mevlana Univ, Yeni Istanbul Cad 235, TR-42003 Selcuklu Konya, Turkey.
EM ayselkiyici@gmail.com
RI , Kamile/GLT-1034-2022
OI , Kamile/0000-0002-6585-7019
FU Scientific Research Projects Unit of Selcuk University [BAP09202038]
FX This study was carried out with the grant from the Scientific Research
   Projects Unit of Selcuk University (BAP09202038).
CR Arslan M, 2006, TURKIYE KLIN J INTER, V2, P1
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NR 18
TC 7
Z9 7
U1 0
U2 9
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-4196
EI 1557-8518
J9 METAB SYNDR RELAT D
JI Metab. Syndr. Relat. Disord.
PD AUG
PY 2016
VL 14
IS 6
BP 318
EP 321
DI 10.1089/met.2016.0011
PG 4
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA DS5FS
UT WOS:000380807400007
PM 27171014
DA 2025-06-11
ER

PT J
AU Lyon, D
   McCain, N
   Elswick, RK
   Sturgill, J
   Ameringer, S
   Jallo, N
   Menzies, V
   Robins, J
   Starkweather, A
   Walter, J
   Grap, MJ
AF Lyon, Debra
   McCain, Nancy
   Elswick, R. K.
   Sturgill, Jamie
   Ameringer, Suzanne
   Jallo, Nancy
   Menzies, Victoria
   Robins, JoLynne
   Starkweather, Angela
   Walter, Jeanne
   Grap, Mary Jo
TI Biobehavioral examination of fatigue across populations: Report from a
   P30 Center of Excellence
SO NURSING OUTLOOK
LA English
DT Article
DE Fatigue: PROMIS; Depressive symptoms: P30; Big data
ID INFLAMMATION; ADOLESCENTS; DEPRESSION; CYTOKINES; OUTCOMES; STRESS;
   SCALE
AB Objectives: This article reports the cross-studies analysis of projects from the P30 Center of Excellence for Biobehavioral Approaches to Symptom Management. Although the projects investigated diverse populations, a consistent theoretical and empirical approach guided each project.
   Methods: Common data elements included the following measures of psychobehavioral variables: the PROMIS Short-Form Fatigue Scale, the Center of Epidemiologic Studies Depression Scale, and the Perceived Stress Scale. Plasma cytokines were measured as the shared biological data element.
   Results: Data were analyzed from 295 participants with fibromyalgia (n = 72), second trimester pregnancy (n = 73), sickle cell anemia (n = 60), and cardiometabolic risk (n = 91). The mean age of participants was 35.4 years, and the most participants were female. Levels of symptoms were generally elevated across samples; the level of fatigue ranged from 18.9 to 24.7, depressive symptoms from 12.5 to 23.4, and perceived stress from 16.5 to 21.8. Intercorrelations among symptom measures and perceived stress were strong across the samples. However, correlations among psychobehavioral variables and cytokines were variable, indicating a separate relationship for the measures with cytokines.
   Conclusions: Future work in symptom science could benefit from common data elements, including biomarkers, across populations to better develop the taxonomy of symptom profiles across conditions.
C1 [Lyon, Debra] Univ Florida, Coll Nursing, Gainesville, FL 32611 USA.
   [McCain, Nancy; Elswick, R. K.; Sturgill, Jamie; Ameringer, Suzanne; Jallo, Nancy; Menzies, Victoria; Robins, JoLynne; Starkweather, Angela; Walter, Jeanne; Grap, Mary Jo] Virginia Commonwealth Univ, Sch Nursing, Richmond, VA 23220 USA.
C3 State University System of Florida; University of Florida; Virginia
   Commonwealth University
RP Lyon, D (corresponding author), Virginia Commonwealth Univ, 508 S Laurel St, Richmond, VA 23220 USA.
EM delyon@vcu.edu
RI Lyon, Deb/ABF-7547-2021; Starkweather, Angela/HJP-5558-2023
OI Sturgill, Jamie/0000-0001-8856-3227; Starkweather,
   Angela/0000-0001-7168-0144; Ameringer, Suzanne/0000-0002-7389-6261
FU National Institutes of Health (NIH) Common Fund Initiative [U54AR057951,
   U01AR052177, U54AR057943, U54AR057926, U01AR057948, U01AR 052170,
   U01AR057954, U01AR052171, U01AR052181, U01AR057956, U01AR052158,
   U01AR057929, U01AR 057936, U01AR052155, U01AR057971, U01AR057940,
   U01AR057967, U01AR052186]
FX P30 Center of Excellence for Biobehavioral Approaches to Symptom
   Management (P30 NR011403, Grap principal investigator). PROMIS was
   funded with cooperative agreements from the National Institutes of
   Health (NIH) Common Fund Initiative (U54AR057951, U01AR052177,
   U54AR057943, U54AR057926, U01AR057948, U01AR 052170, U01AR057954,
   U01AR052171, U01AR052181, U01AR057956, U01AR052158, U01AR057929, U01AR
   057936, U01AR052155, U01AR057971, U01AR057940, U01AR057967, and
   U01AR052186). The contents of this article uses data developed under
   PROMIS. These contents do not necessarily represent an endorsement by
   the U.S. Federal Government or PROMIS. See www.nihpromis.org for
   additional information on the PROMIS initiative. The authors thank Drs.
   Rita Pickler and Cindy Munro for their work in developing the P30 Center
   of Excellence.
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NR 25
TC 10
Z9 13
U1 1
U2 15
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0029-6554
EI 1528-3968
J9 NURS OUTLOOK
JI Nurs. Outlook
PD SEP-OCT
PY 2014
VL 62
IS 5
BP 322
EP 331
DI 10.1016/j.outlook.2014.06.008
PG 10
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA AP5KE
UT WOS:000342117300005
PM 25218081
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Allshouse, AA
   Santoro, N
   Green, R
   Wong, JYY
   Upchurch, DM
   Neal-Perry, G
   Thurston, RC
   Derby, CA
AF Allshouse, Amanda A.
   Santoro, Nanette
   Green, Robin
   Wong, Jason Y. Y.
   Upchurch, Dawn M.
   Neal-Perry, Genevieve
   Thurston, Rebecca C.
   Derby, Carol A.
TI Religiosity and faith in relation to time to metabolic syndrome for
   Hispanic women in a multiethnic cohort of women-Findings from the Study
   of Women's Health Across the Nation (SWAN)
SO MATURITAS
LA English
DT Article
DE Faith; Religion; Metabolic syndrome; Stress; Hispanic; Midlife; Women's
   health
ID MENTAL-HEALTH; RISK; ACCULTURATION; ATTENDANCE; BEHAVIORS; GENDER;
   ADULTS
AB Objectives: We investigated whether faith was associated with a difference in time to incident metabolic syndrome (MetS) among midlife Hispanic women vs women of other ethnicities.
   Study design: The Study of Women's Health Across the Nation (SWAN) is a community-based, longitudinal study of a cohort of midlife women. Social, demographic, psychosocial, anthropometric, medical, and physiological measures, and incident MetS were assessed in near-annual intervals using questionnaires and assays. Each participant answered key questions related to religion and meaning in her life. Differences in time to MetS were modeled by Hispanic ethnicity (vs. otherwise) among women reporting low and high levels of faith.
   Main outcome measure: Incident MetS in the 7 years after the SWAN baseline assessment.
   Results: Among 2371 women, average baseline age 46, Hispanic women (n = 168) were more likely to have higher perceived stress and financial strain than non-Hispanic women (n = 2203). Nevertheless, Hispanic women were far more likely than non-Hispanic women to report that faith brought them strength and comfort in times of adversity, that they prayed often, and that their faith was sustaining for them. Hispanic women had the highest incidence rate of MetS of any racial/ethnic group. However, among women with high levels of faith, the incidence rate of MetS was similar in the Hispanic and non-Hispanic groups. Conversely, among women with low levels of faith, Hispanic women had a faster progression to MetS than did non-Hispanic women.
   Conclusions: Faith might be associated with a different risk of MetS among women of Hispanic vs other ethnicities. Among women who are not part of a faith community, Hispanic ethnicity might be a risk factor for MetS.
C1 [Allshouse, Amanda A.] Colorado Sch Publ Hlth, Dept Biostat & Informat, Aurora, CO 80045 USA.
   [Santoro, Nanette] Univ Colorado, Sch Med, Dept Obstet & Gynecol, Aurora, CO USA.
   [Green, Robin; Derby, Carol A.] Albert Einstein Coll Med, Saul R Korey Dept Neurol, Bronx, NY 10467 USA.
   [Wong, Jason Y. Y.] NCI, NIH, Div Canc Epidemiol & Genet, Rockville, MD USA.
   [Upchurch, Dawn M.] UCLA, Fielding Sch Publ Hlth, Dept Community Hlth Sci, Los Angeles, CA USA.
   [Neal-Perry, Genevieve] Univ Washington, Dept Obstet & Gynecol, Div Reprod Endocrinol & Infertil, Seattle, WA 98195 USA.
   [Thurston, Rebecca C.] Univ Pittsburgh, Dept Psychiat, Pittsburgh, PA USA.
   [Thurston, Rebecca C.] Univ Pittsburgh, Dept Psychol, Pittsburgh, PA 15260 USA.
   [Thurston, Rebecca C.] Univ Pittsburgh, Dept Epidemiol, Pittsburgh, PA 15261 USA.
   [Derby, Carol A.] Albert Einstein Coll Med, Dept Epidemiol & Populat Hlth, Bronx, NY 10467 USA.
C3 Colorado School of Public Health; University of Colorado System;
   University of Colorado Anschutz Medical Campus; Montefiore Medical
   Center; Albert Einstein College of Medicine; Yeshiva University;
   National Institutes of Health (NIH) - USA; NIH National Cancer Institute
   (NCI); NIH National Cancer Institute- Division of Cancer Epidemiology &
   Genetics; University of California System; University of California Los
   Angeles; University of Washington; University of Washington Seattle;
   Pennsylvania Commonwealth System of Higher Education (PCSHE); University
   of Pittsburgh; Pennsylvania Commonwealth System of Higher Education
   (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of
   Higher Education (PCSHE); University of Pittsburgh; Yeshiva University;
   Montefiore Medical Center; Albert Einstein College of Medicine
RP Allshouse, AA (corresponding author), Colorado Sch Publ Hlth, Dept Biostat & Informat, Aurora, CO 80045 USA.
EM amanda.allshouse@ucdenver.edu
FU National Institutes of Health (NIH), DHHS, through the National
   Institute on Aging (NIA); National Institute of Nursing Research (NINR);
   NIH Office of Research on Women's Health (ORWH) [U01NR004061,
   U01AG012505, U01AG012535, U01AG012531, U01AG012539, U01AG012546,
   U01AG012553, U01AG012554, U01AG012495]
FX The Study of Women's Health Across the Nation (SWAN) has grant support
   from the National Institutes of Health (NIH), DHHS, through the National
   Institute on Aging (NIA), the National Institute of Nursing Research
   (NINR) and the NIH Office of Research on Women's Health (ORWH) (Grants
   U01NR004061; U01AG012505, U01AG012535, U01AG012531, U01AG012539,
   U01AG012546, U01AG012553, U01AG012554, U01AG012495). The content of this
   manuscript is solely the responsibility of the authors and does not
   necessarily represent the official views of the NIA, NINR, ORWH or the
   NIH.
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NR 30
TC 9
Z9 10
U1 0
U2 1
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0378-5122
EI 1873-4111
J9 MATURITAS
JI Maturitas
PD JUN
PY 2018
VL 112
BP 18
EP 23
DI 10.1016/j.maturitas.2018.03.008
PG 6
WC Geriatrics & Gerontology; Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Obstetrics & Gynecology
GA GG2HD
UT WOS:000432509900004
PM 29704912
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Mulya, IC
   Hasan, MA
   Iqhrammullah, M
AF Mulya, Intan Chaharunia
   Hasan, Muhammad Arif
   Iqhrammullah, Muhammad
TI Impact of metabolic syndrome factors on sperm DNA fragmentation in males
   from infertile couples: A systematic review and meta-analysis
SO JOURNAL OF GYNECOLOGY OBSTETRICS AND HUMAN REPRODUCTION
LA English
DT Review
DE Sperm DNA damage; Metabolic syndrome; Oxidative stress; Male infertility
ID BODY-MASS INDEX; OXIDATIVE STRESS; MEN; OBESITY; DIAGNOSIS; DAMAGE;
   HYPERTENSION; INFLAMMATION; MANAGEMENT; FERTILITY
AB Purpose: To investigate the impact of metabolic syndrome factors on sperm DNA fragmentation (sDF) in males from infertile couples. Methods: A systematic literature search was performed across ten databases for literature published from January 1, 2013 until September 13, 2023. The protocol has been registered on PROSPERO (CRD42023458359), and the literature search strategy is adhered to the PRISMA framework. Studies that evaluated sDF, as indicated by DNA fragmentation index (%DFI), in males from infertile couples in relation to metabolic syndrome factors were included. Meta-analysis, using random effects model and Bayesian framework network, was performed, and data were presented as Standardized Mean Differences (SMD) with corresponding 95 % Confidence Interval (CI). Results: Of the 2579 citations identified, eleven studies were included in this meta-analysis. The findings revealed that the %DFI was not associated with overall metabolic syndrome factors (p-tot = 0.235; SMD = 0.57 [95 %CI: -0.37, 1.52]), metabolic syndrome status (p-tot = 0.337; SMD = 0.08 [95 %CI: -0.08, 0.24), increased body mass index (p-tot = 0.237; SMD = 0.71 [95 %CI: -0.47, 1.89]), or glycaemic profile (p-tot = 0.93; SMD = 0.13 [95 % CI: -2.72, 2.98]). High levels of heterogeneity were observed (p < 0.01) in all subgroups, except for metabolic syndrome status. Conclusion: The association between metabolic syndrome factors and sDF is conflicting. However, interpreting the association requires caution, as confounding factors, indicated by high heterogeneity, may conceal the outcome. Metabolic syndrome may influence other factors contributing to male infertility, highlighting the importance of promoting a healthy lifestyle.
C1 [Mulya, Intan Chaharunia] Monash Univ, Dept Obstet & Gynaecol, Educ Program Reprod & Dev, Melbourne, Vic 3168, Australia.
   [Hasan, Muhammad Arif] Teungku Peukan Gen Hosp, Aceh Barat Daya 32764, Indonesia.
   [Iqhrammullah, Muhammad] Univ Muhammadiyah Aceh, Postgrad Program Publ Hlth, Banda Aceh 23245, Indonesia.
C3 Monash University; Universitas Muhammadiyah Aceh
RP Mulya, IC (corresponding author), Monash Univ, Dept Obstet & Gynaecol, Educ Program Reprod & Dev, Melbourne, Vic 3168, Australia.
EM imul0004@student.monash.edu
RI Iqhrammullah, Muhammad/AAT-4629-2020
OI Hasan, Muhammad Arif/0009-0006-8588-2824; Mulya, Intan
   Chaharunia/0009-0008-0155-5661; Iqhrammullah,
   Muhammad/0000-0001-8060-7088
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NR 77
TC 0
Z9 0
U1 1
U2 2
PU ELSEVIER MASSON, CORP OFF
PI PARIS
PA 65 CAMILLE DESMOULINS CS50083 ISSY-LES-MOULINEAUX, 92442 PARIS, FRANCE
SN 2468-7847
EI 1773-0430
J9 J GYNECOL OBSTET HUM
JI J. Gynecol. Obstet. Hum. Reprod.
PD OCT
PY 2024
VL 53
IS 8
AR 102807
DI 10.1016/j.jogoh.2024.102807
EA JUN 2024
PG 11
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA WG3V2
UT WOS:001253685900001
PM 38825166
OA hybrid
DA 2025-06-11
ER

PT J
AU Yamagata, K
   Yamori, Y
AF Yamagata, Kazuo
   Yamori, Yukio
TI Potential Effects of Soy Isoflavones on the Prevention of Metabolic
   Syndrome
SO MOLECULES
LA English
DT Review
DE soy; isoflavones; genistein; daidzein; metabolic syndrome
ID ENDOTHELIAL NITRIC-OXIDE; HIGH-FAT DIET; INSULIN-RESISTANCE;
   CARDIOVASCULAR-DISEASE; POSTMENOPAUSAL WOMEN; OXIDATIVE STRESS;
   BLOOD-PRESSURE; GENISTEIN SUPPLEMENTATION; PHYTOESTROGEN GENISTEIN;
   DIABETES-MELLITUS
AB Isoflavones are polyphenols primarily contained in soybean. As phytoestrogens, isoflavones exert beneficial effects on various chronic diseases. Metabolic syndrome increases the risk of death due to arteriosclerosis in individuals with various pathological conditions, including obesity, hypertension, hyperglycemia, and dyslipidemia. Although the health benefits of soybean-derived isoflavones are widely known, their beneficial effects on the pathogenesis of metabolic syndrome are incompletely understood. This review aims to describe the association between soybean-derived isoflavone intake and the risk of metabolic syndrome development. We reviewed studies on soy isoflavones, particularly daidzein and genistein, and metabolic syndrome, using PubMed, ScienceDirect, and Web of Science. We describe the pathological characteristics of metabolic syndrome, including those contributing to multiple pathological conditions. Furthermore, we summarize the effects of soybean-derived daidzein and genistein on metabolic syndrome reported in human epidemiological studies and experiments using in vitro and in vivo models. In particular, we emphasize the role of soy isoflavones in metabolic syndrome-induced cardiovascular diseases. In conclusion, this review focuses on the potential of soy isoflavones to prevent metabolic syndrome by influencing the onset of hypertension, hyperglycemia, dyslipidemia, and arteriosclerosis and discusses the anti-inflammatory effects of isoflavones.
C1 [Yamagata, Kazuo] Nihon Univ UNBS, Coll Bioresource Sci, Dept Food Biosci & Biotechnol, Fujisawa, Kanagawa 2828510, Japan.
   [Yamori, Yukio] Mukogawa Womens Univ, Inst World Hlth Dev, Nishinomiya, Hyogo 6638143, Japan.
C3 Mukogawa Women's University
RP Yamagata, K (corresponding author), Nihon Univ UNBS, Coll Bioresource Sci, Dept Food Biosci & Biotechnol, Fujisawa, Kanagawa 2828510, Japan.
EM yamagata.kazuo@nihon-u.ac.jp; yamori@cardiacstudy.com
OI Yamagata, Kazuo/0000-0001-7222-6525; Yamori, Yukio/0009-0007-2274-2514
FU Grants-in-Aid for Scientific Research [20K10517] Funding Source: KAKEN
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NR 131
TC 37
Z9 40
U1 10
U2 64
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1420-3049
J9 MOLECULES
JI Molecules
PD OCT
PY 2021
VL 26
IS 19
AR 5863
DI 10.3390/molecules26195863
PG 20
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA WH9GL
UT WOS:000707977000001
PM 34641407
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Novák, P
   Jackson, AO
   Zhao, GJ
   Yin, K
AF Novak, Petr
   Jackson, Ampadu O.
   Zhao, Guo-Jun
   Yin, Kai
TI Bilirubin in metabolic syndrome and associated inflammatory diseases:
   New perspectives
SO LIFE SCIENCES
LA English
DT Review
DE Bilirubin; Diabetes; Hyperbilirubinemia; Metabolic syndrome
ID ENDOTHELIAL-CELL SURVIVAL; SERUM BILIRUBIN; LONGITUDINAL ASSOCIATIONS;
   OXIDATIVE STRESS; HEME OXYGENASE-1; RISK; ATHEROSCLEROSIS; ENDOCARDITIS;
   CONTRIBUTES; PROTECTION
AB Diabetes mellitus is one of the major global health issues, which is closely related to metabolic dysfunction and the chronic inflammatory diseases. Multiple studies have demonstrated that serum bilirubin is negatively correlated with metabolic syndrome and associated inflammatory diseases, including atherosclerosis, hypertension, etc. However, the roles of bilirubin in metabolic syndrome and associated inflammatory diseases still remain unclear. Here, we explain the role of bilirubin in metabolic syndrome and chronic inflammatory diseases and its therapeutic potential. Understanding the role of bilirubin activities in diabetes may serve as a therapeutic target for the treatment of chronic inflammatory diseases in diabetic patients.
C1 [Novak, Petr; Yin, Kai] Guilin Med Univ, Guangxi Key Lab Diabet Syst Med, Guilin 541000, Guangxi, Peoples R China.
   [Jackson, Ampadu O.] Univ South China, Int Coll, Hengyang 421001, Hunan, Peoples R China.
   [Zhao, Guo-Jun] Guangzhou Med Univ, Affiliated Hosp 6, Qingyuan City Peoples Hosp, Qingyuan 511518, Guangdong, Peoples R China.
   [Yin, Kai] Guilin Med Univ, Affiliated Hosp 2, Guilin 541100, Guangxi, Peoples R China.
C3 Guilin Medical University; University of South China; Guangzhou Medical
   University; Guilin Medical University
RP Yin, K (corresponding author), Guilin Med Univ, Guangxi Key Lab Diabet Syst Med, Guilin 541000, Guangxi, Peoples R China.; Zhao, GJ (corresponding author), Guangzhou Med Univ, Affiliated Hosp 6, Qingyuan City Peoples Hosp, Qingyuan 511518, Guangdong, Peoples R China.; Yin, K (corresponding author), Guilin Med Univ, Affiliated Hosp 2, Guilin 541100, Guangxi, Peoples R China.
EM zhaoguojun@gzhmu.edu.cn; kaiyinby@qq.com
RI yin, kai/KHE-2284-2024
FU National Natural Science Foundation of China [81970390, 81470569];
   Foundation for Guangxi Key Laboratory of Diabetic Systems Medicine
   [20-065-77]; Science Foundation of the Health and Family Planning
   Commission in Hunan Province of China [C2019112]; Natural Science
   Foundation of Hunan Province, China [2018JJ2341]; National College
   Students Innovation and Entrepreneurship Fund [201710555015,
   201710555010]
FX This work was supported by the National Natural Science Foundation of
   China [grant numbers 81970390 and 81470569]; the Foundation for Guangxi
   Key Laboratory of Diabetic Systems Medicine [grant number 20-065-77];
   Science Foundation of the Health and Family Planning Commission in Hunan
   Province of China [grant number C2019112]; Natural Science Foundation of
   Hunan Province, China [grant number 2018JJ2341] and the National College
   Students Innovation and Entrepreneurship Fund [grant numbers
   201710555015 and 201710555010].
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NR 87
TC 30
Z9 32
U1 4
U2 29
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0024-3205
EI 1879-0631
J9 LIFE SCI
JI Life Sci.
PD SEP 15
PY 2020
VL 257
AR 118032
DI 10.1016/j.lfs.2020.118032
PG 6
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA NN3SR
UT WOS:000568711600004
PM 32621920
DA 2025-06-11
ER

PT S
AU Diamanti-Kandarakis, E
   Economou, F
AF Diamanti-Kandarakis, Evanthia
   Economou, Frangiskos
BE Chrousos, GP
   Tsigos, C
TI Stress in women - Metabolic syndrome and polycystic ovary syndrome
SO STRESS, OBESITY, AND METABOLIC SYNDROME
SE Annals of the New York Academy of Sciences
LA English
DT Article; Proceedings Paper
CT Bjorntorp Symposium on Stress, Obesity, and Metabolic Syndrome
CY APR 09-10, 2005
CL Athens, GREECE
SP Roche Hellas, Abbott Hellas, Pfizer Hellas, Sanofi Aventis Hellas, GlaxoSmithKline Hellas
DE polycystic ovary syndrome; metabolic syndrome; stress
ID IMPAIRED GLUCOSE-TOLERANCE; LOW-BIRTH-WEIGHT; INSULIN-RESISTANCE;
   CARDIOVASCULAR RISK; DIABETES-MELLITUS; PRECOCIOUS PUBARCHE; PREVALENCE;
   HYPERTENSION; INFLAMMATION; PREDICTORS
AB Polycystic ovary syndrome (PCOS) is a heterogeneous syndrome that is characterized from oligo- or anovulation, clinical and/or biochemical signs of hyperandrogenism, and polycystic ovaries. Clinical expression is determined by genetic as well as environmental factors. Women with PCOS are a specific group of women which have several aspects of metabolic syndrome (MBS). Concomitantly MBS could be part of metabolic abnormalities present in PCOS. Stress has been linked to aggravate the metabolic abnormalities present in MBS. An interaction seems to exist between stress, environmental, as well as genetic factors, starting from the prenatal age and continuing to the adult life. This results in specific endocrinological and metabolic disorders which are shared by women with PCOS and women with MBS.
C1 Univ Athens, Sch Med, Laiko Gen Hosp, Dept Internal Med 1,Endocrine Sect, GR-14578 Athens, Greece.
C3 Athens Medical School; Laiko General Hospital; National & Kapodistrian
   University of Athens
RP Diamanti-Kandarakis, E (corresponding author), Univ Athens, Sch Med, Laiko Gen Hosp, Dept Internal Med 1,Endocrine Sect, 1A Zefyrou Str, GR-14578 Athens, Greece.
EM akandara@otenet.gr
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NR 54
TC 24
Z9 26
U1 7
U2 43
PU BLACKWELL SCIENCE PUBL
PI OXFORD
PA OSNEY MEAD, OXFORD OX2 0EL, ENGLAND
SN 0077-8923
BN 978-1-57331-625-5
J9 ANN NY ACAD SCI
JI Ann.NY Acad.Sci.
PY 2006
VL 1083
BP 54
EP 62
DI 10.1196/annals.1367.006
PG 9
WC Endocrinology & Metabolism; Multidisciplinary Sciences
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Science & Technology - Other Topics
GA BFR90
UT WOS:000244102900006
PM 17148733
DA 2025-06-11
ER

PT J
AU Wang, FX
   Zhu, N
   Zhou, F
   Lin, DX
AF Wang, Fei-Xuan
   Zhu, Nan
   Zhou, Fan
   Lin, Dong-Xiang
TI Natural Aporphine Alkaloids with Potential to Impact Metabolic Syndrome
SO MOLECULES
LA English
DT Review
DE natural aporphine alkaloids; metabolic syndrome; thaliporphine; boldine;
   nuciferine
ID IMPROVES ENDOTHELIAL FUNCTION; ERECTILE DYSFUNCTION; OXIDATIVE STRESS;
   IN-VITRO; BOLDINE; NUCIFERINE; OBESITY; PROTECTS; DISEASE; INJURY
AB The incidence and prevalence of metabolic syndrome has steadily increased worldwide. As a major risk factor for various diseases, metabolic syndrome has come into focus in recent years. Some natural aporphine alkaloids are very promising agents in the prevention and treatment of metabolic syndrome and its components because of their wide variety of biological activities. These natural aporphine alkaloids have protective effects on the different risk factors characterizing metabolic syndrome. In this review, we highlight the activities of bioactive aporphine alkaloids: thaliporphine, boldine, nuciferine, pronuciferine, roemerine, dicentrine, magnoflorine, anonaine, apomorphine, glaucine, predicentrine, isolaureline, xylopine, methylbulbocapnine, and crebanine. We particularly focused on their impact on metabolic syndrome and its components, including insulin resistance and type 2 diabetes mellitus, endothelial dysfunction, hypertension and cardiovascular disease, hyperlipidemia and obesity, non-alcoholic fatty liver disease, hyperuricemia and kidney damage, erectile dysfunction, central nervous system-related disorder, and intestinal microbiota dysbiosis. We also discussed the potential mechanisms of actions by aporphine alkaloids in metabolic syndrome.
C1 [Wang, Fei-Xuan; Zhu, Nan; Zhou, Fan; Lin, Dong-Xiang] Nanjing Inst Prod Qual Inspect, Nanjing 210019, Peoples R China.
   [Zhou, Fan] Southeast Univ, Sch Biol Sci & Med Engn, Nanjing 210096, Peoples R China.
C3 Southeast University - China
RP Wang, FX (corresponding author), Nanjing Inst Prod Qual Inspect, Nanjing 210019, Peoples R China.
EM cyruswangc@gmail.com; nzhuwork@126.com; zhouf0623@foxmail.com;
   lindx8211@126.com
RI WANG, Feixuan/IXD-3438-2023; zhu, nan/AAA-2495-2022
OI WANG, Feixuan/0000-0002-7896-0306
FU National Key R&D Program of China [2019YFF0216703]
FX FundingThis work was funded by a grant from National Key R&D Program of
   China, grant number 2019YFF0216703.
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NR 106
TC 32
Z9 33
U1 4
U2 85
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1420-3049
J9 MOLECULES
JI Molecules
PD OCT
PY 2021
VL 26
IS 20
AR 6117
DI 10.3390/molecules26206117
PG 22
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA WT6VX
UT WOS:000716002100001
PM 34684698
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Chiu, YC
   Bai, YM
   Su, TP
   Chen, TJ
   Chen, MH
AF Chiu, Yu-Chuan
   Bai, Ya-Mei
   Su, Tung-Ping
   Chen, Tzeng-Ji
   Chen, Mu-Hong
TI Ischemic Stroke in Young Adults and Preexisting Psychiatric Disorders A
   Nationwide Case-Control Study
SO MEDICINE
LA English
DT Article
ID MAJOR DEPRESSIVE DISORDER; ALPHA TNF-ALPHA; BIPOLAR DISORDER;
   RISK-FACTORS; FOLLOW-UP; METABOLIC SYNDROME; METAANALYSIS; COHORT;
   SCHIZOPHRENIA; MORTALITY
AB Previous studies showed that psychiatric disorders such as major depression, bipolar disorders, and alcohol misuse are associated with an increased risk of ischemic stroke. However, the link between psychiatric disorders and stroke in the young population is rarely investigated.Using the Taiwan National Health Insurance Research Database, 2063 young adults aged between 18 and 45 years with ischemic stroke and 8252 age- and sex-matched controls were enrolled in our study between 1998 and 2011. Participants who had preexisting psychiatric disorders were identified.After adjusting for preexisting physical disorders and demographic data, patients with ischemic stroke had an increased risk of having preexisting psychiatric disorders, including bipolar disorder (odds ratio [OR]: 2.23, 95% confidence interval [CI]: 1.06 approximate to 4.67), unipolar depression (OR: 2.15, 95% CI: 1.62 approximate to 2.86), anxiety disorders (OR: 2.63, 95% CI: 1.87 approximate to 3.69), and alcohol use disorders (OR: 2.86, 95% CI: 1.79 approximate to 4.57). Young ischemic stroke (age 30 years) was related to the risk of preexisting unipolar depression (OR: 1.49, 95% CI: 1.05 approximate to 2.11), anxiety disorders (OR: 1.99, 95% CI: 1.33 approximate to 2.97), and alcohol use disorders (OR: 2.54, 95% CI: 1.55 approximate to 4.14); very young stroke (age <30 years) was only associated with the risk of preexisting unipolar depression (OR: 4.15, 95% CI: 1.47 approximate to 11.72).Patients who had experienced ischemic stroke at age younger than 45 years had a higher risk of having pre-existing bipolar disorder, unipolar depression, anxiety disorders, and alcohol use disorders than those who did not after adjusting for demographic data and stroke-related medical comorbidities.
C1 [Chiu, Yu-Chuan] Natl Yang Ming Univ, MacKay Mem Hosp, Dept Psychiat, Taipei 112, Taiwan.
   [Bai, Ya-Mei; Su, Tung-Ping; Chen, Mu-Hong] Natl Yang Ming Univ, Taipei Vet Gen Hosp, Dept Psychiat, Taipei 112, Taiwan.
   [Bai, Ya-Mei; Su, Tung-Ping; Chen, Mu-Hong] Natl Yang Ming Univ, Coll Med, Dept Psychiat, Taipei 112, Taiwan.
   [Chen, Tzeng-Ji] Natl Yang Ming Univ, Dept Family Med, Taipei 112, Taiwan.
   [Chen, Tzeng-Ji] Natl Yang Ming Univ, Inst Hosp & Hlth Care Adm, Taipei 112, Taiwan.
C3 National Yang Ming Chiao Tung University; Mackay Memorial Hospital;
   National Yang Ming Chiao Tung University; Taipei Veterans General
   Hospital; National Yang Ming Chiao Tung University; National Yang Ming
   Chiao Tung University; National Yang Ming Chiao Tung University
RP Chen, MH (corresponding author), Dept Psychiat, 201 Shih Pai Rd,Sec 2, Taipei 11217, Taiwan.
EM kremer7119@gmail.com
RI Chen, TJ/AAH-8430-2021; Chen, MuHong/ACJ-6131-2022
FU Taipei Veterans General Hospital [V103E10-001]
FX The study was supported by a grant from Taipei Veterans General Hospital
   (V103E10-001).
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NR 39
TC 13
Z9 13
U1 0
U2 7
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD SEP
PY 2015
VL 94
IS 38
AR e1520
DI 10.1097/MD.0000000000001520
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA DC9HX
UT WOS:000369533200012
PM 26402806
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Lasic, D
   Bevanda, M
   Bosnjak, N
   Uglesic, B
   Glavina, T
   Franic, T
AF Lasic, Davor
   Bevanda, Milenko
   Bosnjak, Nada
   Uglesic, Boran
   Glavina, Trpimir
   Franic, Tomislav
TI METABOLIC SYNDROME AND INFLAMMATION MARKERS IN PATIENTS WITH
   SCHIZOPHRENIA AND RECURRENT DEPRESSIVE DISORDER
SO PSYCHIATRIA DANUBINA
LA English
DT Article
DE schizophrenia; recurrent depressive disorder; metabolic syndrome;
   inflammation markers; CRP; PAI-1
ID C-REACTIVE PROTEIN; BIPOLAR DISORDER; MENTAL-DISORDERS; COMORBIDITY;
   MULTIMORBIDITY; ASSOCIATION; CHOLESTEROL; RISK
AB Background: The high prevalence of metabolic syndrome in patients with psychiatric disorders, almost double the prevalence reported for the general population, is worrying. The aim of this study is to investigate the presence of metabolic syndrome and inflammatory marker levels in patients with schizophrenia and recurrent depressive disorder in a Croatian psychiatric sample.
   Subjects and methods: This study included 62 inpatients with schizophrenia and 62 with recurrent depressive disorder treated at the Department of Psychiatry, University Hospital Centre Split, enrolled from November 2011 until May 2012. The cases were compared to 124 healthy subjects from the general population.
   Results: The presence of metabolic syndrome was found in 56.5% of the patients with schizophrenia and 53.2% of the patients with depression, which was significantly more prevalent than in the control group (32.3%). The levels of inflammation markers (i.e., C-reactive protein and PAI-1) were significantly higher among patients with metabolic syndrome.
   Conclusions: Patients with schizophrenia and recurrent depressive disorder demonstrate a high prevalence of metabolic syndrome that is also related to inflammation processes. In the context of integrative medicine, clinicians and researchers should consider psychiatric patients within a holistic approach.
C1 [Lasic, Davor; Uglesic, Boran; Glavina, Trpimir; Franic, Tomislav] Univ Hosp Ctr Split, Dept Psychiat, Split 21000, Croatia.
   [Bevanda, Milenko] Univ Mostar, Sch Med, Clin Hosp Mostar, Dept Internal Med, Mostar, Bosnia & Herceg.
   [Bosnjak, Nada] Univ Hosp Ctr Split, Dept Med Lab Diag, Split 21000, Croatia.
C3 University of Split; University of Mostar; University of Split
RP Lasic, D (corresponding author), Univ Hosp Ctr Split, Dept Psychiat, Spinciceva 1, Split 21000, Croatia.
EM dlasic@kbsplit.hr
RI Franic, Tomislav/AAW-7084-2021; Uglešić, Boran/E-9193-2017; Glavina,
   Trpimir/E-2753-2017; Franic, Tomislav/H-1367-2017; Lasic,
   Davor/D-6858-2017
OI Franic, Tomislav/0000-0002-5240-7166; Lasic, Davor/0000-0001-7571-0291
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NR 29
TC 37
Z9 41
U1 0
U2 9
PU MEDICINSKA NAKLADA
PI ZAGREB
PA VLASKA 69, HR-10000 ZAGREB, CROATIA
SN 0353-5053
J9 PSYCHIAT DANUB
JI Psychiatr. Danub.
PY 2014
VL 26
IS 3
BP 214
EP 219
PG 6
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA AW2WL
UT WOS:000346147300003
PM 25191767
DA 2025-06-11
ER

PT J
AU Calvin, AD
   Albuquerque, FN
   Lopez-Jimenez, F
   Somers, VK
AF Calvin, Andrew D.
   Albuquerque, Felipe N.
   Lopez-Jimenez, Francisco
   Somers, Virend K.
TI Obstructive Sleep Apnea, Inflammation, and the Metabolic Syndrome
SO METABOLIC SYNDROME AND RELATED DISORDERS
LA English
DT Review
ID POSITIVE AIRWAY PRESSURE; C-REACTIVE PROTEIN; CARDIOVASCULAR
   RISK-FACTORS; PITUITARY-ADRENAL-AXIS; FACTOR-KAPPA-B;
   NECROSIS-FACTOR-ALPHA; BLOOD-PRESSURE; INSULIN-RESISTANCE; OXIDATIVE
   STRESS; LEPTIN LEVELS
AB The combination of metabolic syndrome and obstructive sleep apnea (OSA) has been termed "syndrome Z." The prevalence of both OSA and metabolic syndrome is increasing worldwide, in part linked to the epidemic of obesity. Beyond their epidemiologic relationship, growing evidence suggests that OSA may be causally related to metabolic syndrome. We are only beginning to understand the potential mechanisms underlying the OSA-metabolic syndrome interaction. Although there is no clear consensus, there is growing evidence that alterations in the hypothalamic-pituitary axis, generation of reactive oxygen species (ROS) due to repetitive hypoxia, inflammation, and generation of adipokines may be implicated in the changes associated with both OSA and metabolic syndrome. Whether some or all of these metabolic alterations mechanistically link OSA to metabolic syndrome remains to be proven, but it is an area of intense scientific interest.
C1 [Somers, Virend K.] Mayo Clin, Coll Med, Div Cardiovasc Dis, Rochester, MN 55905 USA.
   [Calvin, Andrew D.] Mayo Clin, Mayo Sch Grad Med Educ, Rochester, MN USA.
C3 Mayo Clinic; Mayo Clinic
RP Somers, VK (corresponding author), Mayo Clin, Coll Med, Div Cardiovasc Dis, 200 1st St SW, Rochester, MN 55905 USA.
EM somers.virend@mayo.edu
RI Calvin, Andrew/MVT-9775-2025
OI Calvin, Andrew/0000-0002-0469-2847
FU National Institutes of Health (NIH) [HL65176, 1 UL1 RR024150, DK081014]
FX Dr. Somers is supported by National Institutes of Health (NIH) grants
   NIH HL65176, NIH 1 UL1 RR024150, and NIH DK081014.
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NR 115
TC 91
Z9 94
U1 0
U2 3
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-4196
EI 1557-8518
J9 METAB SYNDR RELAT D
JI Metab. Syndr. Relat. Disord.
PD AUG
PY 2009
VL 7
IS 4
BP 271
EP 277
DI 10.1089/met.2008.0093
PG 7
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 477UE
UT WOS:000268543600001
PM 19344228
OA Green Published
DA 2025-06-11
ER

PT J
AU Payab, M
   Hasani-Ranjbar, S
   Merati, Y
   Esteghamati, A
   Qorbani, M
   Hematabadi, M
   Rashidian, H
   Shirzad, N
AF Payab, Moloud
   Hasani-Ranjbar, Shirin
   Merati, Yaser
   Esteghamati, Alireza
   Qorbani, Mostafa
   Hematabadi, Mahboobeh
   Rashidian, Hoda
   Shirzad, Nooshin
TI The Prevalence of Metabolic Syndrome and Different Obesity Phenotype in
   Iranian Male Military Personnel
SO AMERICAN JOURNAL OF MENS HEALTH
LA English
DT Article
DE metabolic syndrome; obesity; waist circumference; abdominal obesity;
   blood pressure; lipid profile; fasting blood glucose; military
ID BODY-MASS INDEX; WAIST CIRCUMFERENCE; RISK-FACTORS; ADULTS; POPULATION;
   EPIDEMIOLOGY; DEFINITION; DIAGNOSIS; INDIANS; CHINESE
AB Obesity, especially when concentrated in the abdominal area, is often associated with the presence of metabolic syndrome. Stress, particularly occupational stress, is one of the most important factors contributing to the increased prevalence of metabolic syndrome components among different populations. This study aimed to investigate the prevalence of overweight and obesity as well as the criteria for metabolic syndrome and its risk factors and different obesity phenotype in a population of military personnel aged 20 to 65 years. This study is a retrospective cross-sectional study in which data are extracted from the database of a military hospital (2,200 participants). The records of participants contained information such as age, marital status, educational level, weight, height, body mass index, blood pressure, waist circumference, history of drug use and smoking, as well as the results of tests including lipid profile and fasting blood glucose. The Adult Treatment Panel III criteria as well as two national criteria were used to identify metabolic syndrome among participants. Data analysis was p1erformed using SPSS version 16. The average age of participants was 33.37 (7.75) years. The prevalence of metabolic syndrome according to Iranian cutoff was 26.6% for the waist circumference >90 cm (585 persons) and 19.6% for the waist circumference >95 cm (432 persons). The rate of metabolic syndrome was identified as 11.1% (432 cases) according to Adult Treatment Panel III criteria. Results of the current study identified that the prevalence of metabolic syndrome among military individuals is less than other populations, but the prevalence of the syndrome is higher than other military personnel in other countries.
C1 [Payab, Moloud; Hasani-Ranjbar, Shirin] Univ Tehran Med Sci, Endocrinol & Metab Mol Cellular Sci Inst, Obes & Eating Habits Res Ctr, Tehran, Iran.
   [Hasani-Ranjbar, Shirin; Rashidian, Hoda; Shirzad, Nooshin] Univ Tehran Med Sci, Endocrinol & Metab Res Ctr, Endocrinol & Metab Clin Sci Inst, Tehran, Iran.
   [Merati, Yaser] Univ Tehran Med Sci, Tehran, Iran.
   [Esteghamati, Alireza] Univ Tehran Med Sci, Sch Med, Vali Asr Hosp, EMRC, Tehran, Iran.
   [Qorbani, Mostafa] Alborz Univ Med Sci, Noncommunicable Dis Res Ctr, Karaj, Iran.
   [Hematabadi, Mahboobeh; Shirzad, Nooshin] Univ Tehran Med Sci, Vali Asr Hosp, Imam Khomeini Complex Hosp, Dept Endocrinol, Tehran, Iran.
C3 Tehran University of Medical Sciences; Tehran University of Medical
   Sciences; Tehran University of Medical Sciences; Tehran University of
   Medical Sciences; Alborz University of Medical Sciences; Tehran
   University of Medical Sciences
RP Hasani-Ranjbar, S; Shirzad, N (corresponding author), Shariati Hosp, EMRI, 5th Floor,North Kargar Ave, Tehran 1411413137, Iran.
EM sh_hasani@sina.tums.ac.ir; nshirzad@tums.ac.ir
RI Hemmatabadi, Mahboobeh/A-4915-2019; Shirzad, Nooshin/A-1748-2019;
   Qorbani, Mostafa/M-8171-2017
OI Esteghamati, Alireza/0000-0001-5114-3982; Qorbani,
   Mostafa/0000-0001-9465-7588
FU Tehran University of Medical Sciences (Endocrinology and Metabolism
   Research Institute)
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article:
   Implementation of this study was sponsored by Tehran University of
   Medical Sciences (Endocrinology and Metabolism Research Institute).
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NR 51
TC 22
Z9 28
U1 0
U2 6
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1557-9883
EI 1557-9891
J9 AM J MENS HEALTH
JI Am. J. Mens Health
PD MAR
PY 2017
VL 11
IS 2
BP 404
EP 413
DI 10.1177/1557988316683120
PG 10
WC Public, Environmental & Occupational Health
WE Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA EL7BK
UT WOS:000394775900024
PM 28201955
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Maneesai, P
   Jan-o, B
   Poasakate, A
   Rattanakanokchai, S
   Tong-Un, T
   Phuthong, S
   Pakdeechote, P
AF Maneesai, Putcharawipa
   Jan-o, Banyaphon
   Poasakate, Anuson
   Rattanakanokchai, Siwayu
   Tong-Un, Terdthai
   Phuthong, Sophida
   Pakdeechote, Poungrat
TI Limonin mitigates cardiometabolic complications in rats with metabolic
   syndrome through regulation of the IRS-1/GLUT4 signalling pathway
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Article
DE Limonin; Cardiometabolic disorders; Cardiac changes; Inflammation;
   Oxidative stress
ID HIGH-FAT-DIET; OXIDATIVE STRESS; SUPPRESSION; EXPRESSION; OBESITY;
   SYSTEM; ALPHA; RISK; ACID
AB Limonin is a natural triterpenoid isolated from citrus fruit. In the present study, we examined the effects of limonin on cardiometabolic alterations in diet-induced metabolic syndrome. Metabolic syndrome was induced in rats by feeding them a high-fat (HF) diet plus 15% fructose in drinking water for 16 weeks. They were treated with limonin (50 or 100 mg/kg) (n = 8/group) for the final 4 weeks. Increases in body weight (BW), fasting blood glucose (FBG), serum insulin, total cholesterol (TC), blood pressure (BP), liver fat accumulation, and adipocyte hypertrophy, as well as oral glucose tolerance in rats with metabolic syndrome were alleviated by limonin treatment (p < 0.05). Limonin improved ejection fraction and left ventricular (LV) hypertrophy, and reduced angiotensin converting enzyme (ACE) activity and angiotensin II (Ang II) concentration in rats with metabolic syndrome (p < 0.05). It also reduced plasma tumour necrosis factor (TNF)-alpha, interleukin (IL)-6, leptin, malonaldehyde (MDA), and superoxide generation, and increased catalase activity in rats with metabolic syndrome compared to controls (p < 0.05). Downregulation of insulin receptor substrate 1 (IRS-1) and glucose transporter type 4 (GLUT4) protein expression in epididymal fat pads and cardiac, liver, and gastrocnemius tissues was present in metabolic syndrome, and these were restored by limonin treatment (p < 0.05). In conclusion, limonin shows a potential effect in alleviating symptoms and improving cardiometabolic disorders. These beneficial effects are linked to the reduction of the renin-angiotensin system, inflammation, oxidative stress, and improvement of IRS-1/GLUT4 protein expression in the target tissue.
C1 [Maneesai, Putcharawipa; Jan-o, Banyaphon; Poasakate, Anuson; Tong-Un, Terdthai; Phuthong, Sophida; Pakdeechote, Poungrat] Khon Kaen Univ, Fac Med, Dept Physiol, Khon Kaen 40002, Thailand.
   [Rattanakanokchai, Siwayu] Khon Kaen Univ, Fac Vet Med, Khon Kaen 40002, Thailand.
C3 Khon Kaen University; Khon Kaen University
RP Pakdeechote, P (corresponding author), Khon Kaen Univ, Fac Med, Dept Physiol, Khon Kaen 40002, Thailand.
EM putcma@kku.ac.th; banyaphonj@kkumail.com; anuson_p@kkumail.com;
   Siwara@kku.ac.th; terdthai@kku.ac.th; sophiph@kku.ac.th;
   ppoung@kku.ac.th
RI Maneesai, Putcharawipa/AAK-4258-2021
OI Tong-un, Terdthai/0000-0002-5286-0788; Maneesai,
   Putcharawipa/0000-0003-0889-6211
FU National Research Council of Thailand (NRCT) [N42A650239]
FX Funding This project was funded by the National Research Council of
   Thailand (NRCT) . (N42A650239) .
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NR 54
TC 5
Z9 5
U1 1
U2 9
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD MAY
PY 2023
VL 161
AR 114448
DI 10.1016/j.biopha.2023.114448
EA FEB 2023
PG 11
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA C9CL2
UT WOS:000964813300001
PM 36857910
OA gold
DA 2025-06-11
ER

PT J
AU Schäffer, L
   Müller-Vizentini, D
   Burkhardt, T
   Rauh, M
   Ehlert, U
   Beinder, E
AF Schaeffer, Leonhard
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   Burkhardt, Tilo
   Rauh, Manfred
   Ehlert, Ulrike
   Beinder, Ernst
TI Blunted Stress Response in Small for Gestational Age Neonates
SO PEDIATRIC RESEARCH
LA English
DT Article
ID PITUITARY-ADRENAL AXIS; LOW-BIRTH-WEIGHT; HPA AXIS; BLOOD-PRESSURE;
   FETAL-GROWTH; ADULT LIFE; PSYCHOLOGICAL STRESS; CORTISOL RESPONSE;
   PRETERM INFANTS; PRENATAL STRESS
AB There is evidence that adverse conditions during intrauterine development affect future health of the offspring. Hypothalamus-pituitary-adrenal (HPA) axis dysregulation is assumed to play an important role in the association of small for gestational age (SGA) and the pathogenesis of hypertension and the metabolic syndrome. Stress response patterns in SGA neonates may identify a link with intrauterine-induced permanent maladaptation of the HPA axis. Salivary cortisol and cortisone levels were therefore analyzed during resting conditions and in response to a pain-induced stress event in SGA (< 5th percentile) and appropriate for gestational age (AGA) neonates born <= 34 wk of gestation. In AGA neonates, salivary cortisol and cortisone levels significantly increased after the stress event (p < 0.05). In contrast. SGA infants exhibited a blunted steroid release after stress induction (p = 0,76 p = 0.65, respectively). No influence of mode of delivery (p = 0.93). gender 0.21). and gestational age (p = 0.57) on stress response patterns was observed in a multiple stepwise regression. SGA neonates show a blunted physiologic activation of the HPA axis in response to a stress stimulus. Thus. intrauterine-induced alteration of HPA axis regulation seems to persist into the postnatal period and represents a prerequisite for the hypothesis of HPA axis involvement in file fetal origin of adult diseases. (Pediatr Res 65: 231-235, 2009)
C1 [Schaeffer, Leonhard; Mueller-Vizentini, Deborah; Burkhardt, Tilo; Beinder, Ernst] Univ Zurich, Dept Obstet, CH-8091 Zurich, Switzerland.
   [Ehlert, Ulrike] Univ Zurich, Inst Psychol, CH-8091 Zurich, Switzerland.
   [Rauh, Manfred] Univ Erlangen Nurnberg, Dept Pediat, D-91052 Erlangen, Germany.
C3 University of Zurich; University of Zurich; University of Erlangen
   Nuremberg
RP Schäffer, L (corresponding author), Univ Frauenklin, Frauenklin Str 10, CH-8091 Zurich, Switzerland.
EM leonhard.schaeffer@usz.ch
OI Rauh, Manfred/0000-0002-4852-7157; Schaffer,
   Leonhard/0000-0001-8272-7761
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NR 53
TC 33
Z9 33
U1 0
U2 3
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 0031-3998
EI 1530-0447
J9 PEDIATR RES
JI Pediatr. Res.
PD FEB
PY 2009
VL 65
IS 2
BP 231
EP 235
DI 10.1203/PDR.0b013e318191fb44
PG 5
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA 398XX
UT WOS:000262766100019
PM 18948839
OA Bronze
DA 2025-06-11
ER

PT J
AU Dresner, D
   Barnett, KG
   Resnick, K
   Laird, LD
   Gardiner, P
AF Dresner, Danielle
   Barnett, Katherine Gergen
   Resnick, Kirsten
   Laird, Lance D.
   Gardiner, Paula
TI Listening to Their Words: A Qualitative Analysis of Integrative Medicine
   Group Visits in an Urban Underserved Medical Setting
SO PAIN MEDICINE
LA English
DT Article
DE Group Medical Visit; Integrative Medicine; Chronic Pain;
   Mindfulness-Based Stress Reduction; Qualitative Methods
ID LOW-BACK-PAIN; STRESS REDUCTION; SELF-MANAGEMENT; PRIMARY-CARE;
   MINDFULNESS; EDUCATION; ACUPUNCTURE; EFFICACY; MASSAGE
AB Objective. Integrative Medicine Group Visits (IMGVs) are an 8-week outpatient medical group visit program for chronic pain patients combining mindfulness-based stress reduction (MBSR), integrative medicine, and patient education. The authors conducted a qualitative study with IMGV participants to better understand the effects of IMGVs on patients' health.
   Design. This qualitative study enrolled a convenience sample of 19 participants from the parent prospective observational cohort study of IMGVs (n = 65). All participants in the parent study were invited to participate.
   Setting. Boston Medical Center (BMC) is a private, not-for-profit, 496-bed, academic medical center and the largest safety net hospital in New England.
   Subjects. Individuals in this study had a diagnosis of chronic pain and/or one or more chronic conditions (e.g., diabetes, depression, or metabolic syndrome), had attended a parts per thousand yen1 group visit, and their 8-week session had ended before completing the interview.
   Methods. The authors conducted individual semi-structured interviews. Interviews were audio-taped, transcribed, and analyzed.
   Results. Participants cite gains from IMGVs including improved self-monitoring, self-regulation, and increased mindfulness. The group setting leads patients to feel "not alone" in their health conditions, gain a sense of perspective on their health, and share coping strategies in a supportive network. These improvements in physical and mental health improved clinical outcomes for participants including reductions in pain.
   Conclusions. Group visits and integrative medicine both offer some potential solutions in the treatment of chronic pain. Models such as IMGVs can help individuals living with chronic conditions, addressing their emotional and physical health needs.
C1 [Dresner, Danielle; Barnett, Katherine Gergen; Resnick, Kirsten; Laird, Lance D.; Gardiner, Paula] Boston Univ, Sch Med, Dept Family Med, Boston, MA 02118 USA.
C3 Boston University
RP Dresner, D (corresponding author), 1 Boston Med Ctr Pl,Dowling 5 South,Room 5305B, Boston, MA 02118 USA.
EM danielle.dresner@bmc.org
RI ; Laird, Lance/G-5310-2015
OI Gardiner, Paula/0000-0002-3663-000X; Laird, Lance/0000-0003-4831-3850
FU private family fund
FX This work was supported by a private family fund.
CR [Anonymous], PRIMARY CARE INTERVE
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NR 32
TC 20
Z9 26
U1 0
U2 15
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1526-2375
EI 1526-4637
J9 PAIN MED
JI Pain Med.
PD JUN
PY 2016
VL 17
IS 6
BP 1183
EP 1191
DI 10.1093/pm/pnw030
PG 9
WC Anesthesiology; Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Anesthesiology; General & Internal Medicine
GA DR2RO
UT WOS:000379751800021
PM 27040666
OA Bronze
DA 2025-06-11
ER

PT J
AU Jylhävä, J
   Lehtimäki, T
   Jula, A
   Moilanen, L
   Kesäniemi, YA
   Nieminen, MS
   Kähönen, M
   Hurme, M
AF Jylhava, Juulia
   Lehtimaki, Terho
   Jula, Antti
   Moilanen, Leena
   Kesaniemi, Y. Antero
   Nieminen, Markku S.
   Kahonen, Mika
   Hurme, Mikko
TI Circulating cell-free DNA is associated with cardiometabolic risk
   factors: The Health 2000 Survey
SO ATHEROSCLEROSIS
LA English
DT Article
DE cf-DNA; Cardiometabolic risk; Arterial stiffness; Early atherosclerosis;
   Biomarker
ID MYOCARDIAL-INFARCTION; INSULIN-RESISTANCE; OXIDATIVE STRESS; APOPTOSIS;
   INFLAMMATION; MORTALITY; ESTRADIOL; LIVER
AB Cell-free circulating DNA (cf-DNA) has recently arisen as a promising biomarker in acute cardiovascular pathologies and as a mortality predictor in myocardial infarction. We wanted to investigate whether the baseline cf-DNA concentration could serve as an indicator of increased cardiovascular risk and early atherosclerosis. The study population consisted of 1337 participants (aged 46-77 years) in the Health 2000 Survey. cf-DNA was quantified directly in plasma using the fluorescence-based Quant-iT (TM) high-sensitivity DNA assay kit. Increased cf-DNA levels paralleled a cluster of cardiometabolic risk factors, such as high blood pressure, unfavorable lipid metabolism profile and systemic inflammation in both sexes. In addition, higher cf-DNA levels indicated decreased arterial elasticity and glucose intolerance in women not using hormonal replacement therapy (HRT). The cf-DNA level was also observed to be an independent determinant for Young's elastic modulus but not for carotid artery compliance or beta stiffness index in the women not using HRT. Hence, we conclude that cf-DNA could serve as an auxiliary biomarker in cardiometabolic risk assessment and as an indicator of arterial stiffness in women not using HRT. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
C1 [Jylhava, Juulia; Hurme, Mikko] Univ Tampere, Sch Med, Dept Microbiol & Immunol, FIN-33014 Tampere, Finland.
   [Lehtimaki, Terho] Fimlab Labs, Dept Clin Chem, Tampere, Finland.
   [Lehtimaki, Terho] Univ Tampere, Sch Med, FIN-33014 Tampere, Finland.
   [Jula, Antti] Natl Inst Hlth & Welf, Dept Chron Dis Prevent, Turku, Finland.
   [Moilanen, Leena] Kuopio Univ Hosp, Dept Med, SF-70210 Kuopio, Finland.
   [Kesaniemi, Y. Antero] Univ Oulu, Dept Med, Inst Clin Med, Oulu, Finland.
   [Kesaniemi, Y. Antero] Oulu Univ Hosp, Clin Res Ctr, Oulu, Finland.
   [Nieminen, Markku S.] Helsinki Univ Hosp, Dept Med, FI-00029 Hus Helsinki, Finland.
   [Kahonen, Mika] Tampere Univ Hosp, Dept Clin Physiol, Tampere, Finland.
   [Kahonen, Mika] Univ Tampere, FIN-33014 Tampere, Finland.
   [Hurme, Mikko] Fimlab Labs, Tampere, Finland.
C3 Tampere University; Tampere University; Finland National Institute for
   Health & Welfare; University of Eastern Finland; University of Eastern
   Finland Hospital; Kuopio University Hospital; University of Oulu;
   University of Oulu; University of Helsinki; Helsinki University Central
   Hospital; Tampere University; Tampere University Hospital; Tampere
   University
RP Jylhävä, J (corresponding author), Univ Tampere, Sch Med, Dept Microbiol & Immunol, FIN-33014 Tampere, Finland.
EM juulia.jylhava@uta.fi
RI Gratten, Jacob/G-1485-2011; Lehtimäki, Terho/AAD-1094-2022
OI Hurme, Mikko/0000-0002-8614-1044; Kahonen, Mika/0000-0002-4510-7341;
   Lehtimaki, Terho/0000-0002-2555-4427; Jylhava,
   Juulia/0000-0003-0250-4491
FU Tampere University Hospital [9N013, 9N035]; Finnish Foundation of
   Cardiovascular Research; Tampere Tuberculosis Foundation
FX The authors wish to thank Sinikka Repo-Koskinen for her skillful
   technical assistance. The study was financially supported by the
   Competitive State Research Financing of the Expert Responsibility area
   of Tampere University Hospital, grant number 9N013 (M. H) and 9N035 (T.
   L), Finnish Foundation of Cardiovascular Research (T. L) and Tampere
   Tuberculosis Foundation (T.L).
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   Aromaa A., 2004, Health and Functional Capacity in Finland. Baseline Results of the Health 2000 Health Examination Survey
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   Jylhävä J, 2012, EXP GERONTOL, V47, P372, DOI 10.1016/j.exger.2012.02.011
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   Kerksick C, 2008, MED SCI SPORT EXER, V40, P1772, DOI 10.1249/MSS.0b013e31817d1cce
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   Malo E, 2011, METAB SYNDR RELAT D, V9, P203, DOI 10.1089/met.2010.0106
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NR 25
TC 48
Z9 49
U1 0
U2 20
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0021-9150
EI 1879-1484
J9 ATHEROSCLEROSIS
JI Atherosclerosis
PD MAR
PY 2014
VL 233
IS 1
BP 268
EP 271
DI 10.1016/j.atherosclerosis.2013.12.022
PG 4
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA AB1OZ
UT WOS:000331563400044
PM 24529155
DA 2025-06-11
ER

PT J
AU Azadbakht, L
   Kimiagar, M
   Mehrabi, Y
   Esmaillzadeh, A
   Hu, FB
   Willett, WC
AF Azadbakht, Leila
   Kimiagar, Masoud
   Mehrabi, Yadollah
   Esmaillzadeh, Ahmad
   Hu, Frank B.
   Willett, Walter C.
TI Dietary soya intake alters plasma antioxidant status and lipid
   peroxidation,q in postmenopausal women with the metabolic syndrome
SO BRITISH JOURNAL OF NUTRITION
LA English
DT Article
DE soya; oxidative stress; metabolic syndrome; postmenopausal women;
   antioxidant capacity
ID LOW-DENSITY-LIPOPROTEIN; OXIDATIVE STRESS; PROTEIN; ISOFLAVONES; ACID;
   PHYTOESTROGENS; CAPACITY; FOODS; INFLAMMATION; CONSUMPTION
AB Postmenopausal women with the metabolic syndrome are at high risk of oxidative stress. Several studies have suggested possible antioxidant properties of soya, but little evidence is available regarding the effect of soya on oxidative stress in postmenopausal women with the metabolic syndrome. The objective of the present study was to determine the effects of soya consumption on plasma total antioxidant capacity (TAC) and malondialdehyde (MDA) level in postmenopausal women with the metabolic syndrome. A randomised cross-over trial was undertaken on forty-two postmenopausal women with the metabolic syndrome. Participants were randomly assigned to consume a control (Dietary Approaches to Stop Hypertension; DASH) diet, a soya protein diet, or a soya nut diet, each for 8 weeks. Red meat in the DASH diet (one serving per d) was replaced by soya protein in the soya protein period and by soya nuts in the soya nut period. Significant differences between the end values of the control diet, soya protein diet and soya nut diet were seen for MDA (0.70, 0.64 and 0.63 mu mol/l; global P<0.01). The results also showed a significant difference between the end values for TAC (1950, 2030 and 2110 mu mol/l, respectively; P<0.01). The difference from control for TAC was +4.5% (P<0.01) in the soya nut period and +5.8% (P<0.01) in the soya protein regimen. Both soya nuts and soya protein decreased MDA significantly compared with the control diet (difference from control was -7.9% (P<0.01) in the soya nut period and -9.4% (P<0.01) in the soya protein diet). We conclude that soya consumption reduces plasma MDA and increases plasma TAC levels in postmenopausal women with the metabolic syndrome.
C1 Isfahan Univ Med Sci, Sch Hlth, Dept Nutr, Esfahan, Iran.
   Isfahan Univ Med Sci, Nutr Res Ctr, Esfahan, Iran.
   Shahid Beheshti Univ Med Sci, Sch Nutr & Food Sci, Dept Human Nutr, Tehran, Iran.
   Shahid Beheshti Univ Med Sci, Sch Publ Hlth, Tehran, Iran.
   Harvard Sch Publ Hlth, Dept Nutr, Boston, MA USA.
   Harvard Sch Publ Hlth, Dept Epidemiol, Boston, MA USA.
C3 Isfahan University of Medical Sciences; Isfahan University of Medical
   Sciences; Shahid Beheshti University Medical Sciences; Shahid Beheshti
   University Medical Sciences; Harvard University; Harvard T.H. Chan
   School of Public Health; Harvard University; Harvard T.H. Chan School of
   Public Health
RP Azadbakht, L (corresponding author), Isfahan Univ Med Sci, Sch Hlth, Dept Nutr, PO Box 81745, Esfahan, Iran.
EM azadbakht@hlth.mui.ac.ir
RI Willett, Walter/E-2352-2013; Hu, Frank/C-1919-2013; Azadbakht,
   Leila/N-2801-2018; Mehrabi, Yadollah/J-4211-2016; Mehrabi,
   Yadollah/J-4211-2016; Esmaillzadeh, Ahmad/N-5704-2014
OI Azadbakht, Leila/0000-0002-5955-6818; Mehrabi,
   Yadollah/0000-0001-9837-4956; Mehrabi, Yadollah/0000-0001-8555-6160;
   Esmaillzadeh, Ahmad/0000-0002-8735-6047
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NR 50
TC 54
Z9 59
U1 1
U2 9
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1145
EI 1475-2662
J9 BRIT J NUTR
JI Br. J. Nutr.
PD OCT
PY 2007
VL 98
IS 4
BP 807
EP 813
DI 10.1017/S0007114507746871
PG 7
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 230VC
UT WOS:000250903200020
PM 17506931
OA Green Submitted, Bronze
DA 2025-06-11
ER

PT J
AU Soni, R
   Shah, JG
AF Soni, Ritu
   Shah, Jigna
TI Deciphering Intertwined Molecular Pathways Underlying Metabolic Syndrome
   Leading to Parkinson's Disease
SO ACS CHEMICAL NEUROSCIENCE
LA English
DT Review; Early Access
DE Parkinson's disease; metabolic syndrome; alpha-synuclein; oxidative
   stress; neuroinflammation; mitochondrial impairment
ID RENIN-ANGIOTENSIN SYSTEM; ALPHA-SYNUCLEIN; MOUSE MODEL;
   INSULIN-RESISTANCE; DOPAMINERGIC-NEURONS; CELLULAR MECHANISMS; OXIDATIVE
   STRESS; HYPERTENSION; OBESITY; PATHOPHYSIOLOGY
AB Parkinson's disease (PD) is a neurodegenerative disorder that gradually develops over time in a progressive manner. The main culprit behind the disease pathology is dopaminergic deficiency in Substantia nigra Pars Compacta (SNpc) due to neuronal degeneration. However, there are other factors that are not only associated with it but also somehow responsible for inception of pathology. Metabolic syndrome is one such risk factor for PD. Metabolic syndrome is a cluster of diseases mainly including diabetes, hypertension, obesity, and hyperlipidemia which pose a risk for developing cardiovascular disorders. All of these disorders have their own pathological pathways that intertwine with PD pathology. This leads to alpha-synuclein aggregation, neuro-inflammation, mitochondrial dysfunction, and oxidative stress which are facets in initiating PD pathology. Although few reports are available, this area is underexplored and has contradictory views. Hence, further studies are needed in order to establish a definite relationship between PD and metabolic syndrome. In this review, we aim to elucidate the molecular mechanisms to confirm the association between them and pave the way for potential repurposing of therapies.
C1 [Soni, Ritu; Shah, Jigna] Nirma Univ, Inst Pharm, Dept Pharmacol, Ahmadabad 382481, Gujarat, India.
C3 Nirma University
RP Shah, JG (corresponding author), Nirma Univ, Inst Pharm, Dept Pharmacol, Ahmadabad 382481, Gujarat, India.
EM jigna.shah@nirmauni.ac.in
OI Shah, Jigna/0000-0001-9722-4526; Soni, Ritu/0000-0002-8760-3941
FU Institute of Pharmacy, Nirma University, Ahmedabad, Gujarat, India
FX This supplement was supported by the seed fund of the Institute of
   Pharmacy, Nirma University, Ahmedabad, Gujarat, India.
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NR 114
TC 10
Z9 10
U1 1
U2 3
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1948-7193
J9 ACS CHEM NEUROSCI
JI ACS Chem. Neurosci.
PD 2022 JUL 20
PY 2022
DI 10.1021/acschemneuro.2c00165
EA JUL 2022
PG 12
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Neurosciences
   & Neurology
GA 3H1JO
UT WOS:000831798300001
PM 35856649
DA 2025-06-11
ER

PT J
AU Baumer, Y
   Pita, MA
   Baez, AS
   Ortiz-Whittingham, LR
   Cintron, MA
   Rose, RR
   Gray, VC
   Baah, FO
   Powell-Wiley, TM
AF Baumer, Yvonne
   Pita, Mario A.
   Baez, Andrew S.
   Ortiz-Whittingham, Lola R.
   Cintron, Manuel A.
   Rose, Rebecca R.
   Gray, Veronica C.
   Baah, Foster Osei
   Powell-Wiley, Tiffany M.
TI By what molecular mechanisms do social determinants impact
   cardiometabolic risk?
SO CLINICAL SCIENCE
LA English
DT Review
ID CORTICOTROPIN-RELEASING HORMONE; CHRONIC PSYCHOLOGICAL STRESS;
   FACTOR-LIKE IMMUNOREACTIVITY; COURSE SOCIOECONOMIC-STATUS;
   PRO-INFLAMMATORY CYTOKINES; SELF-REPORTED EXPERIENCES; PROTEIN-COUPLED
   RECEPTORS; LEUKOCYTE TELOMERE LENGTH; EPIDERMAL-GROWTH-FACTOR; ACUTE
   CORONARY SYNDROME
AB While it is well known from numerous epidemiologic investigations that social determinants (socioeconomic, environmental, and psychosocial factors exposed to over the life-course) can dramatically impact cardiovascular health, the molecular mechanisms by which social determinants lead to poor cardiometabolic outcomes are not well understood. This review comprehensively summarizes a variety of current topics surrounding the biological effects of adverse social determinants (i.e., the biology of adversity), linking translational and laboratory studies with epidemiologic findings. With a strong focus on the biological effects of chronic stress, we highlight an array of studies on molecular and immunological signaling in the context of social determinants of health (SDoH). The main topics covered include biomarkers of sympathetic nervous system and hypothalamic-pituitary-adrenal axis activation, and the role of inflammation in the biology of adversity focusing on glucocorticoid resistance and key inflammatory cytokines linked to psychosocial and environmental stressors (PSES). We then further discuss the effect of SDoH on immune cell distribution and characterization by subset, receptor expression, and function. Lastly, we describe epigenetic regulation of the chronic stress response and effects of SDoH on telomere length and aging. Ultimately, we highlight critical knowledge gaps for future research as we strive to develop more targeted interventions that account for SDoH to improve cardiometabolic health for at-risk, vulnerable populations.
C1 [Baumer, Yvonne; Pita, Mario A.; Baez, Andrew S.; Ortiz-Whittingham, Lola R.; Cintron, Manuel A.; Rose, Rebecca R.; Gray, Veronica C.; Baah, Foster Osei; Powell-Wiley, Tiffany M.] NHLBI, Social Determinants Obes & Cardiovasc Risk Lab, Cardiovasc Branch, Div Intramural Res,NIH, Bethesda, MD 20824 USA.
   [Powell-Wiley, Tiffany M.] NIMHHD, Intramural Res Program, NIH, Bethesda, MD 20824 USA.
C3 National Institutes of Health (NIH) - USA; NIH National Heart Lung &
   Blood Institute (NHLBI); Division of Intramural Research (DIR); National
   Institutes of Health (NIH) - USA
RP Powell-Wiley, TM (corresponding author), NHLBI, Social Determinants Obes & Cardiovasc Risk Lab, Cardiovasc Branch, Div Intramural Res,NIH, Bethesda, MD 20824 USA.; Powell-Wiley, TM (corresponding author), NIMHHD, Intramural Res Program, NIH, Bethesda, MD 20824 USA.
EM tiffany.powell@nih.gov
RI Baah, Foster/HKW-8106-2023; PowellWiley, Tiffany/MCY-2981-2025
OI Rose, Raviv/0000-0002-7711-2209; Ortiz-Whittingham,
   Lola/0000-0002-9085-1591
FU Division of Intramural Research of the National, Heart, Lung, and Blood
   Institute of the NIH; Intramural Research Program of the National
   Institute on Minority Health and Health Disparities
FX The Powell-Wiley Lab is funded by the Division of Intramural Research of
   the National, Heart, Lung, and Blood Institute of the NIH and the
   Intramural Research Program of the National Institute on Minority Health
   and Health Disparities.
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NR 271
TC 17
Z9 17
U1 0
U2 1
PU PORTLAND PRESS LTD
PI LONDON
PA 1ST FLR, 10 QUEEN STREET PLACE, LONDON, ENGLAND
SN 0143-5221
EI 1470-8736
J9 CLIN SCI
JI Clin. Sci.
PD MAR
PY 2023
VL 137
IS 6
BP 469
EP +
DI 10.1042/CS20220304
PG 27
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA F3BT8
UT WOS:000981140000002
PM 36960908
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Siskind, DJ
   Harris, M
   Phillipou, A
   Morgan, VA
   Waterreus, A
   Galletly, C
   Carr, VJ
   Harvey, C
   Castle, D
AF Siskind, D. J.
   Harris, M.
   Phillipou, A.
   Morgan, V. A.
   Waterreus, A.
   Galletly, C.
   Carr, V. J.
   Harvey, C.
   Castle, D.
TI Clozapine users in Australia: their characteristics and experiences of
   care based on data from the 2010 National Survey of High Impact
   Psychosis
SO EPIDEMIOLOGY AND PSYCHIATRIC SCIENCES
LA English
DT Article
DE Clozapine; metabolic syndrome; schizophrenia; substance use; treatment
   refractory schizophrenia
ID SOCIAL PERFORMANCE SCALE; ANTIPSYCHOTIC USE; DETECT CHANGE;
   SCHIZOPHRENIA; RELIABILITY; DISORDERS; VALIDITY; ABILITY; TOLERABILITY;
   PREVALENCE
AB Aims. Clozapine is the most effective medication for treatment refractory schizophrenia. However, descriptions of the mental health and comorbidity profile and care experiences of people on clozapine in routine clinical settings are scarce. Using data from the 2010 Australian Survey of High Impact Psychosis, we aimed to examine the proportion of people using clozapine, and to compare clozapine users with other antipsychotic users on demographic, mental health, adverse drug reaction, polypharmacy and treatment satisfaction variables.
   Methods. Data describing 1049 people with a diagnosis of schizophrenia or schizoaffective disorder, who reported taking any antipsychotic medication in the previous 4 weeks, were drawn from a representative Australian survey of people with psychotic disorders in contact with mental health services in the previous 12 months. We compared participants taking clozapine (n = 257, 22.4%) with those taking other antipsychotic medications, on a range of demographic, clinical and treatment-related indicators.
   Results. One quarter of participants were on clozapine. Of participants with a chronic course of illness, only one third were on clozapine. After adjusting for diagnosis and illness chronicity, participants taking clozapine had significantly lower odds of current alcohol, cannabis and other drug use despite similar lifetime odds. Metabolic syndrome and diabetes were more common among people taking clozapine; chronic pain was less common. Psychotropic polypharmacy did not differ between groups.
   Conclusions. Consistent with international evidence of clozapine underutilisation, a large number of participants with chronic illness and high symptom burden were not taking clozapine. The lower probabilities of current substance use and chronic pain among clozapine users warrant further study.
C1 [Siskind, D. J.] Univ Queensland, Sch Med, Brisbane, Qld, Australia.
   [Siskind, D. J.] Metro South Addict & Mental Hlth Serv Hlth, Brisbane, Qld, Australia.
   [Siskind, D. J.; Harris, M.] Queensland Ctr Mental Hlth, Policy & Epidemiol Grp, Brisbane, Qld, Australia.
   [Harris, M.] Univ Queensland, Sch Publ Hlth, Brisbane, Qld, Australia.
   [Phillipou, A.; Castle, D.] St Vincents Hosp, Melbourne, Vic, Australia.
   [Phillipou, A.; Harvey, C.; Castle, D.] Univ Melbourne, Sch Med, Melbourne, Vic, Australia.
   [Morgan, V. A.; Waterreus, A.] Univ Western Australia, Sch Psychiat & Clin Neurosci, Neuropsychiat Epidemiol Res Unit, Perth, WA, Australia.
   [Galletly, C.] Univ Adelaide, Sch Psychiat, Adelaide, SA, Australia.
   [Carr, V. J.] Univ New South Wales, Sch Psychiat, Randwick, NSW, Australia.
   [Carr, V. J.] Monash Univ, Dept Psychiat, Clayton, Vic, Australia.
   [Harvey, C.] NorthWestern Mental Hlth, Melbourne, Vic, Australia.
C3 University of Queensland; University of Queensland; St Vincent's Health;
   St Vincent's Hospital Melbourne; NSW Health; St Vincents Hospital
   Sydney; University of Melbourne; University of Western Australia;
   University of Adelaide; University of New South Wales Sydney; Monash
   University
RP Siskind, DJ (corresponding author), MIRT, 519 Kessels Rd, Macgregor, Qld, Australia.
EM d.siskind@uq.edu.au
RI Harvey, Carol/KHB-1944-2024; Morgan, Vera/U-4851-2019; Harris,
   Meredith/ABD-3049-2020; Siskind, Dan/A-9812-2014
OI Harris, Meredith/0000-0003-0096-729X; Castle, David/0000-0002-3075-1580;
   Siskind, Dan/0000-0002-2072-9216; Waterreus, Anna/0000-0002-1648-7701
FU National Health and Medical Research Council, Early Career Fellowship
   [APP1111136]; Australian Government Department of Health and Ageing
FX The 2010 Australian National Survey of High Impact Psychosis was funded
   by the Australian Government Department of Health and Ageing. D J
   Siskind is supported by a National Health and Medical Research Council,
   Early Career Fellowship 2016-2019 (APP1111136).
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NR 45
TC 23
Z9 23
U1 2
U2 10
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 2045-7960
EI 2045-7979
J9 EPIDEMIOL PSYCH SCI
JI Epidemiol. Psychiatr. Sci.
PD JUN
PY 2017
VL 26
IS 3
BP 325
EP 337
DI 10.1017/S2045796016000305
PG 13
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA ET9ZE
UT WOS:000400667800016
PM 27426892
OA Green Published
DA 2025-06-11
ER

PT J
AU Mejía-Guzmán, JE
   Belmont-Hernández, RA
   Chávez-Tapia, NC
   Uribe, M
   Nuño-Lámbarri, N
AF Mejia-Guzman, Jeysson E.
   Belmont-Hernandez, Ramon A.
   Chavez-Tapia, Norberto C.
   Uribe, Misael
   Nuno-Lambarri, Natalia
TI Metabolic-Dysfunction-Associated Steatotic Liver Disease: Molecular
   Mechanisms, Clinical Implications, and Emerging Therapeutic Strategies
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE MASLD; lipogenesis; chronic inflammation; oxidative stress; biomarkers;
   emerging therapies
ID NONALCOHOLIC STEATOHEPATITIS; MITOCHONDRIAL DYSFUNCTION; EXTRAHEPATIC
   OUTCOMES; OXIDATIVE STRESS; CONTROLLED-TRIAL; KUPFFER CELLS; RESMETIROM;
   FIBROSIS; NASH; IRISIN
AB Metabolic-dysfunction-associated steatotic liver disease (MASLD), previously known as non-alcoholic fatty liver disease (NAFLD), is a highly prevalent metabolic disorder characterized by hepatic steatosis in conjunction with at least one cardiometabolic risk factor, such as obesity, type 2 diabetes, hypertension, or dyslipidemia. As global rates of obesity and metabolic syndrome continue to rise, MASLD is becoming a major public health concern, with projections indicating a substantial increase in prevalence over the coming decades. The disease spectrum ranges from simple steatosis to metabolic-dysfunction-associated steatohepatitis (MASH), fibrosis, cirrhosis, and hepatocellular carcinoma, contributing to significant morbidity and mortality worldwide. This review delves into the molecular mechanisms driving MASLD pathogenesis, including dysregulation of lipid metabolism, chronic inflammation, oxidative stress, mitochondrial dysfunction, and gut microbiota alterations. Recent advances in research have highlighted the role of genetic and epigenetic factors in disease progression, as well as novel therapeutic targets such as peroxisome proliferator-activated receptors (PPARs), fibroblast growth factors, and thyroid hormone receptor beta agonists. Given the multifaceted nature of MASLD, a multidisciplinary approach integrating early diagnosis, molecular insights, lifestyle interventions, and personalized therapies is critical. This review underscores the urgent need for continued research into innovative treatment strategies and precision medicine approaches to halt MASLD progression and improve patient outcomes.
C1 [Mejia-Guzman, Jeysson E.; Belmont-Hernandez, Ramon A.; Chavez-Tapia, Norberto C.; Nuno-Lambarri, Natalia] Med Sur Clin & Fdn, Translat Res Unit, Mexico City 14050, Mexico.
   [Belmont-Hernandez, Ramon A.] Univ Autonoma Metropolitana Iztapalapa, Postgrad Program Expt Biol, Div Ciencias Bas & Salud DCBS, Mexico City 09340, Mexico.
   [Chavez-Tapia, Norberto C.; Uribe, Misael] Med Sur Clin & Fdn, Obes & Digest Dis Unit, Mexico City 14050, Mexico.
   [Nuno-Lambarri, Natalia] Natl Autonomous Univ Mexico UNAM, Fac Med, Surg Dept, Mexico City 04510, Mexico.
C3 Universidad Autonoma Metropolitana - Mexico; Universidad Nacional
   Autonoma de Mexico
RP Nuño-Lámbarri, N (corresponding author), Med Sur Clin & Fdn, Translat Res Unit, Mexico City 14050, Mexico.; Nuño-Lámbarri, N (corresponding author), Natl Autonomous Univ Mexico UNAM, Fac Med, Surg Dept, Mexico City 04510, Mexico.
EM jey18112000@gmail.com; belher_2094ra@hotmail.com;
   nchavezt@medicasur.org.mx; muribe@medicasur.org.mx;
   nnunol@medicasur.org.mx
RI Nuño-Lámbarri, Natalia/KBD-4162-2024
FU Medica Sur Clinic and Foundation
FX We received educational and research support from Medica Sur Clinic and
   Foundation.
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NR 182
TC 1
Z9 1
U1 1
U2 1
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD MAR 25
PY 2025
VL 26
IS 7
AR 2959
DI 10.3390/ijms26072959
PG 42
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 1FR4J
UT WOS:001463918100001
PM 40243565
OA gold
DA 2025-06-11
ER

PT J
AU Kuhail, M
   Djafarian, K
   Shab-Bidar, S
   Yaseri, M
AF Kuhail, Mohamed
   Djafarian, Kurosh
   Shab-Bidar, Sakineh
   Yaseri, Mehdi
TI Major dietary patterns and metabolic syndrome associated with severity
   of coronary artery disease: A structural equation modeling
SO NUTRITION AND HEALTH
LA English
DT Article
DE Dietary patterns; severity of coronary artery disease; Gensini score;
   metabolic syndrome; physical activity; perceived stress scale;
   structural equation modeling
ID TYPE-2 DIABETES PATIENTS; CARDIOVASCULAR-DISEASE; PHYSICAL-ACTIVITY;
   MEDITERRANEAN DIET; CONTEMPORARY DATA; SYNDROME SCORE; GAZA-STRIP;
   PREVALENCE; PALESTINE; QUESTIONNAIRE
AB Background: The association of dietary patterns and metabolic syndrome with the severity of coronary artery disease (CAD) is little known. Aim: This study aimed to explore the relationship between major dietary patterns and the severity of CAD among newly discovered patients by using structural equation modeling (SEM). Methods: In this cross-sectional study, we included 423 newly diagnosed patients with CAD, aged 35-65 years, who underwent coronary angiography. The severity of CAD was assessed by the Gensini score. All patients were tested by using a semi-quantitative food frequency questionnaire, international physical activity questionnaire, perceived stress scale, lipid profile, fasting blood glucose, and anthropometric and blood pressure measurements. Statistical analysis was performed using SPSS and AMOS version 24. Results: Two dietary patterns (DPs) were identified by principal components analysis and labeled as "unhealthy DP" and "healthy DP". The results of SEM analysis showed that the unhealthy DP has a significant positive direct association with the severity of CAD (beta=0.304, p<0.001), which is indirectly mediated by the presence of metabolic syndrome (beta=0.021, p=0.021), adjusted for age and perceived stress scale. However, healthy DP has a significant negative direct association with the Gensini score (beta=-0.213, p<0.001), and an indirect association through negative metabolic syndrome (beta=-0.019, p=0.022), controlled for gender, physical activity, and perceived stress scale. Conclusions: The severity of CAD was directly associated with the unhealthy DP and indirectly mediated by the presence of the metabolic syndrome, while a healthy DP had a direct inverse association with CAD severity and indirectly mediated by the absence of metabolic syndrome.
C1 [Kuhail, Mohamed; Djafarian, Kurosh] Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Clin Nutr, Int Campus, Tehran, Iran.
   [Shab-Bidar, Sakineh] Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Community Nutr, Int Coll, POB 14155-6117, Tehran, Iran.
   [Yaseri, Mehdi] Univ Tehran Med Sci, Sch Publ Hlth, Dept Epidemiol & Biostat, Tehran, Iran.
C3 Tehran University of Medical Sciences; Tehran University of Medical
   Sciences; Tehran University of Medical Sciences
RP Shab-Bidar, S (corresponding author), Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Community Nutr, Int Coll, POB 14155-6117, Tehran, Iran.
EM s_shabbidar@tums.ac.ir
RI Shab-Bidar, Sakineh/H-9525-2017; djafarian, kurosh/D-5563-2018; Yaseri,
   Mehdi/I-1645-2018
OI Kuhail, Mohamed/0000-0002-2527-3318; Yaseri, Mehdi/0000-0002-4066-873X
FU Tehran University of Medical Sciences
FX The authors disclosed receipt of the following financial support for the
   research, authorship, and/or publication of this article: This
   manuscript has been granted by the Tehran University of Medical
   Sciences.
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SN 0260-1060
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SC Nutrition & Dietetics
GA CL7K1
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PM 34151612
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   Li, Zhe
   Zhao, Xueli
   Yin, Ming
   Du, Xiangdong
   Zhang, Xiangyang
TI Clinical correlates of autoimmune thyroiditis and non-autoimmune
   hypothyroidism in treatment-naive patients with major depressive
   disorders
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Major depressive disorder; Autoimmune thyroiditis; Subclinical
   hypothyroidism; Non-autoimmune hypothyroidism; Suicide attempts
ID SUBCLINICAL HYPOTHYROIDISM; MENTAL-DISORDERS; PREVALENCE; POPULATION;
   SYMPTOMS; CHINA; SCALE; MOOD; AGE
AB Background: Thyroid autoimmunity is a potentially critical factor that is often neglected in the association be-tween subclinical hypothyroidism (SCH) and depressive disorders. This study aimed to investigate the clinical correlates of autoimmune thyroiditis (AIT) and non-autoimmune hypothyroidism (NAIH) in treatment-naive patients with major depressive disorder (MDD).
   Method: Using a cross-sectional design, we recruited a total of 1718 outpatients with treatment-naive MDD. Demographic and relevant clinical information including duration of MDD, severity of depression and anxiety, psychotic symptoms, suicide attempts, thyroid function parameters, etc. were collected. According to thyroid function parameters, patients were classified as AIT, NAIH, latent Hashimoto's thyroiditis (LH) and euthyroidism (ET).
   Results: Patients with SCH (including AIT and NAIH) had older age at onset, and were more likely to have psychotic symptoms compared to those with ET. Multiple linear regression analysis showed that SCH was associated with duration of MDD and HAMD scores. Logistic regression analysis showed that the odds of having more severe anxiety and metabolic syndrome were greater among patients with SCH compared to those with ET. The odds of having suicide attempts were greater among patients with AIT than among those with ET. Limitation: Because of the cross-sectional design of this study, we were unable to sort out causality between MDD and SCH.
   Conclusion: Our findings suggested that AIT and NAIH were associated with duration of MDD, HAMD scores, severity of anxiety, and metabolic syndrome. However, only AIT in SCH was associated with suicide attempts.
C1 [Wu, Siqi; Wang, Haitao] North China Univ Sci & Technol, Sch Psychol & Mental Hlth, Tangshan, Peoples R China.
   [Wu, Siqi; Zhou, Yue; Xia, Xingzhi; Yue, Yan; Wu, Yuxuan; Peng, Ruijie; Yang, Ruchang; Li, Ronghua; Yuan, Nian; Li, Zhe; Zhao, Xueli; Yin, Ming; Du, Xiangdong] Soochow Univ, Suzhou Guangji Hosp, Affiliated Guangji Hosp, Suzhou 215137, Peoples R China.
   [Zhou, Yue; Xia, Xingzhi] Xuzhou Med Univ, Xuzhou, Jiangsu, Peoples R China.
   [Yue, Yan; Wu, Yuxuan; Peng, Ruijie; Yang, Ruchang] Soochow Univ, Med Coll, Suzhou, Peoples R China.
   [Zhang, Xiangyang] Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China.
C3 North China University of Science & Technology; Soochow University -
   China; Xuzhou Medical University; Soochow University - China; Chinese
   Academy of Sciences; Institute of Psychology, CAS
RP Du, XD (corresponding author), Soochow Univ, Suzhou Guangji Hosp, Affiliated Guangji Hosp, Suzhou 215137, Peoples R China.; Zhang, XY (corresponding author), Chinese Acad Sci, Inst Psychol, 16 Lincui Rd, Beijing 100101, Peoples R China.
EM xiangdong-du@163.com; zhangxy@psych.ac.cn
RI Li, Ronghua/AAP-8236-2021; Wu, Siqi/JPA-3025-2023; Zhang,
   Xiangyang/ABC-7380-2022; xiang, yan/KIG-7705-2024; wang,
   haitao/GYR-0186-2022
OI Zhang, Xiangyang/0000-0003-3326-382X
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NR 57
TC 7
Z9 7
U1 2
U2 16
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD FEB 15
PY 2023
VL 323
BP 755
EP 761
DI 10.1016/j.jad.2022.12.037
EA DEC 2022
PG 7
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA 7T6GZ
UT WOS:000911543900001
PM 36529413
DA 2025-06-11
ER

PT J
AU Saeidi, A
   Soltani, M
   Daraei, A
   Nohbaradar, H
   Haghighi, MM
   Khosravi, N
   Johnson, KE
   Laher, I
   Hackney, AC
   VanDusseldorp, TA
   Zouhal, H
AF Saeidi, Ayoub
   Soltani, Mohammad
   Daraei, Ali
   Nohbaradar, Hanieh
   Haghighi, Marjan Mosalman
   Khosravi, Nikoo
   Johnson, Kelly E.
   Laher, Ismail
   Hackney, Anthony C.
   VanDusseldorp, Trisha A.
   Zouhal, Hassane
TI The Effects of Aerobic-Resistance Training and Broccoli Supplementation
   on Plasma Dectin-1 and Insulin Resistance in Males with Type 2 Diabetes
SO NUTRIENTS
LA English
DT Article
DE aerobic-strength training; concurrent exercise training; HOMA-IR;
   inflammation; body mass index; fat percent; broccoli
ID OXIDATIVE STRESS; METABOLIC SYNDROME; TNF-ALPHA; EXERCISE; INFLAMMATION;
   ACTIVATION; SPROUTS; OBESITY; DIET; LDL
AB Background: This study aimed to evaluate the effects of a combination of aerobic-resistance training (CARET) and broccoli supplementation on dectin-1 levels and insulin resistance in men with type 2 diabetes mellitus (T2D). Methods: Forty-four males with T2D were randomly allocated to four groups (n = 11 each group): CARET + broccoli supplement (TS), CARET + placebo (TP), control + broccoli supplement (S), and control + placebo (CP). CARET was performed three days per week for 12 weeks. TS and S groups received 10 g of broccoli supplement per day for 12 weeks. All variables were assessed at baseline and 12 weeks. Results: Plasma dectin-1 levels were decreased in TS and TP groups compared with the CP group (p < 0.05). Cardiometabolic risk factors showed significant reductions in TP and TS groups compared to S and CP groups (p < 0.05). Conclusion: The combination of CARET and broccoli supplementation produced the largest improvements in insulin resistance and dectin-1 and other complications of T2D.
C1 [Saeidi, Ayoub] Univ Kurdistan, Dept Phys Educ & Sport Sci, Sanandaj 6617715175, Iran.
   [Soltani, Mohammad] Shahid Beheshti Univ, Fac Sports Sci & Hlth, Dept Biol Sci Sport, Tehran 1983969411, Iran.
   [Daraei, Ali] Univ British Columbia, Sch Hlth & Exercise Sci, Kelowna, BC V1V 1V7, Canada.
   [Nohbaradar, Hanieh; Khosravi, Nikoo] Alzahra Univ, Fac Sports & Exercise Sci, Tehran 1993893973, Iran.
   [Haghighi, Marjan Mosalman] Univ Sydney, Fac Med & Hlth, Sydney, NSW 2006, Australia.
   [Johnson, Kelly E.] Coastal Carolina Univ, Dept Kinesiol, Conway, SC 29526 USA.
   [Laher, Ismail] Univ British Columbia, Dept Anesthesiol Pharmacol & Therapeut, Vancouver, BC BV6T 1Z3, Canada.
   [Hackney, Anthony C.] Univ N Carolina, Dept Exercise & Sport Sci, Chapel Hill, NC 27599 USA.
   [Hackney, Anthony C.] Univ N Carolina, Dept Nutr, Chapel Hill, NC 27599 USA.
   [VanDusseldorp, Trisha A.] Kennesaw State Univ, Dept Exercise Sci & Sport Management, Kennesaw, GA 30144 USA.
   [Zouhal, Hassane] Univ Rennes, M2S Lab Mouvement Sport Sante EA 1274, F-35000 Rennes, France.
C3 University of Kurdistan; Shahid Beheshti University; University of
   British Columbia; Alzahra University; University of Sydney; Coastal
   Carolina University; University of British Columbia; University of North
   Carolina; University of North Carolina Chapel Hill; University of North
   Carolina; University of North Carolina Chapel Hill; University System of
   Georgia; Kennesaw State University; Universite de Rennes
RP VanDusseldorp, TA (corresponding author), Kennesaw State Univ, Dept Exercise Sci & Sport Management, Kennesaw, GA 30144 USA.; Zouhal, H (corresponding author), Univ Rennes, M2S Lab Mouvement Sport Sante EA 1274, F-35000 Rennes, France.
EM saeidi_as68@yahoo.com; m.soltani904@gmail.com; alidaraei01994@gmail.com;
   haniye70_sa@yahoo.com; marjan.mosalmanhaghighi@sydney.edu.au;
   nikukh@alzahra.ac.ir; kjohns10@coastal.edu; ismail.laher@ubc.ca;
   ach@email.unc.edu; tvanduss@kennesaw.edu; hassane.zouhal@univ-rennes2.fr
RI khosravi, nikoo/ACI-9304-2022; Laher, Ismail/L-3947-2013; HACKNEY,
   ANTHONY/D-9521-2013; saeidi, ayoub/U-1931-2019; Mosalman Haghighi,
   Marjan/W-9396-2019; Daraei, Ali/ABD-3099-2021; ZOUHAL,
   Hassane/AAE-6877-2021
OI Saeidi, Ayoub/0000-0003-2458-6256; ZOUHAL, Hassane/0000-0001-6743-6464;
   Laher, Ismail/0000-0002-3917-4417; Soltani, Mohammad/0000-0002-8659-9477
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NR 50
TC 16
Z9 16
U1 0
U2 17
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD SEP
PY 2021
VL 13
IS 9
AR 3144
DI 10.3390/nu13093144
PG 14
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA UX9GE
UT WOS:000701143700001
PM 34579020
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Ohara, K
   Kiyotani, Y
   Uchida, A
   Nagasaka, R
   Maehara, H
   Kanemoto, S
   Hori, M
   Ushio, H
AF Ohara, Kazuyuki
   Kiyotani, Yuka
   Uchida, Asako
   Nagasaka, Reiko
   Maehara, Hiroyuki
   Kanemoto, Shigeharu
   Hori, Masatoshi
   Ushio, Hideki
TI Oral administration of γ-aminobutyric acid and γ-oryzanol prevents
   stress-induced hypoadiponectinemia
SO PHYTOMEDICINE
LA English
DT Article
DE Adiponectin; GABA; gamma-Oryzanol; Metabolic syndrome; Immobilization
   stress
ID DIET-INDUCED OBESITY; METABOLIC SYNDROME; RICE BRAN; GLUCOCORTICOID
   METABOLISM; ADIPONECTIN; FAT; COMPONENTS; PROTEINS
AB Metabolic syndrome is a cluster of risk factors including insulin resistance and type 2 diabetes and is found to associate partly with chronic stress at work in human. Adiponectin circulates in mammal blood mainly as a low molecular weight (LMW) trimer, hexamer, and a high molecular weight (HMW) multimers. Low circulating levels of adiponectin are related to metabolic syndrome. We have then investigated the influence of immobilization stress on plasma adiponectin concentrations in mice. Relative LMW and HMW adiponectin levels were markedly reduced by immobilization stress (0.66 +/- 0.07 and 0.59 +/- 0.06 after 102 h, respectively), significantly different from the control values (p<0.01 and 0.05, respectively). gamma-Aminobutyric acid (GABA) and gamma-oryzanol abundantly contained in germinated brown rice have some physiological functions. We further investigated the effect of GABA, gamma-oryzanol, GABA plus gamma-oryzanol on adiponectin levels in mice subjected to immobilization stress. GABA and gamma-oryzanol significantly increased the relative LMW and HMW adiponectin levels under immobilization stress (1.10 +/- 0.11 and 0.99 +/- 0.19 after 102 h, respectively, for GABA; 1.08 +/- 0.17 and 1.15 +/- 0.17 after 102 h, respectively, for gamma-oryzanol). Additionally, the co-administration of GABA and gamma-oryzanol also increased both relative LMW and HMW adiponectin levels (1.02 +/- 0.07 and 0.99 +/- 0.10 after 102 h, respectively) and was effective in an earlier phase from 30 to 54 h. The results indicate that the co-administration of GABA and gamma-oryzanol might be effective in preventing stress-induced hypoadiponectinemia in mice and be also a promising tool for improving metabolic syndrome aggravated by chronic stress. (C) 2011 Elsevier GmbH. All rights reserved.
C1 [Ushio, Hideki] Univ Tokyo, Grad Sch Agr & Life Sci, Marine Biochem Lab, Bunkyo Ku, Tokyo 1138657, Japan.
   [Ohara, Kazuyuki; Kiyotani, Yuka; Uchida, Asako; Nagasaka, Reiko; Ushio, Hideki] Tokyo Univ Marine Sci & Technol, Dept Food Sci & Technol, Minato Ku, Tokyo 1088477, Japan.
   [Maehara, Hiroyuki; Kanemoto, Shigeharu] Satake Corp, Hiroshima 7398602, Japan.
   [Hori, Masatoshi] Univ Tokyo, Grad Sch Agr & Life Sci, Dept Vet Pharmacol, Tokyo 1138657, Japan.
C3 University of Tokyo; Tokyo University of Marine Science & Technology;
   University of Tokyo
RP Ushio, H (corresponding author), Univ Tokyo, Grad Sch Agr & Life Sci, Marine Biochem Lab, Bunkyo Ku, 1-1 Yayoi 1, Tokyo 1138657, Japan.
EM aushio@mail.ecc.u-tokyo.ac.jp
RI Ushio, Hideki/GYR-3746-2022; Nagasaka, Reiko/O-1985-2014
OI Nagasaka, Reiko/0000-0001-6157-9384
FU Ministry of Education, Culture, Sports, Science, and Technology of
   Japan; Grants-in-Aid for Scientific Research [23658174, 22658089,
   21380178] Funding Source: KAKEN
FX This work is supported in part by a Grant-in-Aid from the Ministry of
   Education, Culture, Sports, Science, and Technology of Japan.
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NR 35
TC 17
Z9 21
U1 1
U2 19
PU ELSEVIER GMBH
PI MUNICH
PA HACKERBRUCKE 6, 80335 MUNICH, GERMANY
SN 0944-7113
EI 1618-095X
J9 PHYTOMEDICINE
JI Phytomedicine
PD JUN 15
PY 2011
VL 18
IS 8-9
BP 655
EP 660
DI 10.1016/j.phymed.2011.01.003
PG 6
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA 809DG
UT WOS:000294031400006
PM 21316207
DA 2025-06-11
ER

PT J
AU Dandona, P
   Ghanim, H
   Mohanty, P
   Chaudhuri, A
AF Dandona, Paresh
   Ghanim, Husam
   Mohanty, Priya
   Chaudhuri, Ajay
TI The metabolic syndrome: Linking oxidative stress and inflammation to
   obesity, type 2 diabetes, and the syndrome
SO DRUG DEVELOPMENT RESEARCH
LA English
DT Article; Proceedings Paper
CT 2nd Annual Metabolic Diseases World Summit on New Drugs for Metabolic
   Syndrome
CY MAY 18-21, 2006
CL Long Beach, CA
DE metabolic syndrome; inflammation; oxidative stress; obesity
ID NECROSIS-FACTOR-ALPHA; C-REACTIVE PROTEIN; ELEVATION
   MYOCARDIAL-INFARCTION; FACTOR-KAPPA-B; PLASMINOGEN-ACTIVATOR
   INHIBITOR-1; RANDOMIZED CONTROLLED-TRIAL; INSULIN-POTASSIUM INFUSION;
   SPECIES ROS GENERATION; MONONUCLEAR-CELLS; ADIPOSE-TISSUE
AB Metabolic syndrome defined by a cluster of clinical features increases the risk of cardiovascular disease and type 2 diabetes mellitus. The original hypothesis linking this syndrome to these diseases was based on insulin resistance and the effect of hyperinsulinemia on atherogenesis. However, inflammatory processes have now been linked to the pathogenesis of atherosclerosis and insulin resistance. Novel data have shown the effect of macronutrients on inflammatory mediators and the anti-inflammatory effects of insulin that is secreted in response to food intake. This review attempts to provide an alternative explanation for the pathogenesis of the metabolic syndrome and the increase in risk of cardiovascular disease and diabetes on the basis of these findings.
C1 SUNY Buffalo, Div Endocrinol Diabet & Metab, Buffalo, NY 14209 USA.
   Kaleida Hlth, Buffalo, NY 14209 USA.
C3 State University of New York (SUNY) System; University at Buffalo, SUNY;
   Kaleida Health
RP Dandona, P (corresponding author), SUNY Buffalo, Div Endocrinol Diabet & Metab, 3 Gates Circle, Buffalo, NY 14209 USA.
EM pdandona@kaleidahealth.org
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NR 56
TC 8
Z9 10
U1 2
U2 11
PU WILEY-LISS
PI HOBOKEN
PA DIV JOHN WILEY & SONS INC, 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 0272-4391
J9 DRUG DEVELOP RES
JI Drug Dev. Res.
PD JUL
PY 2006
VL 67
IS 7
BP 619
EP 626
DI 10.1002/ddr.20137
PG 8
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 108XM
UT WOS:000242272500020
DA 2025-06-11
ER

PT J
AU Hernández, EAG
   Portillo, SAD
   Anaya, OCV
   Valle, MDG
   Flores, JDB
   Chávez, RS
   Galindo, GC
   Mondragón, LD
   Cobos, DS
   Guerrero, GAM
   Sánchez, PL
AF Guzman Hernandez, Elizabeth Alejandrina
   Diaz Portillo, Silvana Andrea
   Villafuerte Anaya, Oscar Cristobal
   Gonzalez Valle, Maria Del Rosario
   Benitez Flores, Jose Del Carmen
   San Miguel Chavez, Ruben
   Chirino Galindo, Gladys
   Del Valle Mondragon, Leonardo
   Segura Cobos, David
   Magos Guerrero, Gil Alfonso
   Lopez Sanchez, Pedro
TI RENOPROTECTIVE AND HEPATOPROTECTIVE EFFECTS OF HIPPOCRATEA
   EXCELSA ON METABOLIC SYNDROME IN FRUCTOSE-FED RATS
SO FARMACIA
LA English
DT Article
DE Hippocratea excelsa; kidney disease; metabolic syndrome; liver damage
ID HIGH-FAT DIET; OXIDATIVE STRESS; EXPERIMENTAL-MODEL; OBESITY; LOSARTAN;
   RENIN; ASSAY; DYSLIPIDEMIA; HYPERTENSION; ALDOSTERONE
AB The metabolic syndrome is associated with the development of chronic kidney disease and liver damage. The aim of this research was to determine the effect of the ethanol bark extract of Hippocratea excelsa (HE) on high fructose consumption-induced adverse effects in the kidney and liver of rats. Rats with 20% fructose feeding for 12 weeks showed arterial hypertension, obesity, dyslipidaemia and developed oxidative stress, proteinuria, the activities of antioxidant enzymes in the renal cortex and liver were decreased, TGF-beta 1 increased, and kidney and liver damage were observed. After the treatment for 6 weeks with HE (30 and 100 mg/kg bw) renoprotective and hepatoprotective effects in high fructose induced metabolic syndrome in rats, were demonstrated.
C1 [Guzman Hernandez, Elizabeth Alejandrina; Diaz Portillo, Silvana Andrea; Villafuerte Anaya, Oscar Cristobal; Lopez Sanchez, Pedro] Natl Polytech Inst, Higher Sch Med, Postgrad Studies & Res Sect, Mexico City 11340, DF, Mexico.
   [Guzman Hernandez, Elizabeth Alejandrina; Chirino Galindo, Gladys; Segura Cobos, David] Univ Nacl Autonoma Mexico, Fac Super Studies Iztacala, Tlalnepantla 54090, State Of Mexico, Mexico.
   [Gonzalez Valle, Maria Del Rosario; Benitez Flores, Jose Del Carmen] Univ Nacl Autonoma Mexico, Histol Lab, Morphol & Funct Unit, Fac Super Studies Iztacala, Tlalnepantla 54090, State Of Mexico, Mexico.
   [San Miguel Chavez, Ruben] Postgrad Coll, Phytochem Area, Postgrad Degree Bot, Campus Montecillo,Km 36-5 Mexico Texcoco Rd, Texcoco 56230, State Of Mexico, Mexico.
   [Del Valle Mondragon, Leonardo] Natl Inst Cardiol Ignacio Chavez, Dept Pharmacol, Mexico City 04510, DF, Mexico.
   [Magos Guerrero, Gil Alfonso] Univ Nacl Autonoma Mexico, Fac Med, Dept Pharmacol, Mexico City 04510, DF, Mexico.
C3 Instituto Politecnico Nacional - Mexico; Universidad Nacional Autonoma
   de Mexico; Universidad Nacional Autonoma de Mexico; National Institute
   of Cardiology - Mexico; Universidad Nacional Autonoma de Mexico
RP Hernández, EAG (corresponding author), Natl Polytech Inst, Higher Sch Med, Postgrad Studies & Res Sect, Mexico City 11340, DF, Mexico.; Hernández, EAG (corresponding author), Univ Nacl Autonoma Mexico, Fac Super Studies Iztacala, Tlalnepantla 54090, State Of Mexico, Mexico.
EM shponia2000@yahoo.com.mx
RI valle, maria/KII-1654-2024
FU National Council for Science and Technology (Mexico); Mexican Council of
   Science and Technology
FX This work was supported by National Council for Science and Technology
   (Mexico) and Mexican Council of Science and Technology (2016),
   fellowship to Elizabeth Alejandrina Guzman Hernandez as part of his
   post-doctoral research.
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NR 51
TC 4
Z9 4
U1 0
U2 10
PU SOC STIINTE FARMACEUTICE ROMANIA
PI BUCURESTI
PA BUCURESTI, STR TRAIAN VUIA 6, SECT 1, BUCURESTI, 020956, ROMANIA
SN 0014-8237
EI 2065-0019
J9 FARMACIA
JI Farmacia
PD NOV-DEC
PY 2020
VL 68
IS 6
BP 1106
EP 1119
DI 10.31925/farmacia.2020.6.19
PG 14
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA PH9JF
UT WOS:000600718700020
OA gold
DA 2025-06-11
ER

PT J
AU Tang, YZ
   Purkayastha, S
   Cai, DS
AF Tang, Yizhe
   Purkayastha, Sudarshana
   Cai, Dongsheng
TI Hypothalamic microinflammation: a common basis of metabolic syndrome and
   aging
SO TRENDS IN NEUROSCIENCES
LA English
DT Review
ID NF-KAPPA-B; NEURAL STEM-CELLS; EXTRACELLULAR-SUPEROXIDE DISMUTASE;
   ENDOPLASMIC-RETICULUM STRESS; GAMMA AGONIST ROSIGLITAZONE; LIFE-SPAN
   EXTENSION; OXIDATIVE STRESS; GENE-EXPRESSION; CALORIC RESTRICTION;
   INSULIN-RESISTANCE
AB Chronic microinflammation is a hallmark of many aging-related neurodegenerative diseases as well as metabolic syndrome-driven diseases. Recent research indicates that chronic caloric excess can lead to hypothalamic microinflammation, which in turn participates in the development and progression of metabolic syndrome disorders such as obesity, glucose intolerance, and hypertension. Additionally, it was recently shown that increasing age after young adulthood can cause hypothalamic microinflammation independently of nutritional status, mediating a central mechanism of systemic aging. Taken together, these findings suggest that the hypothalamus has a fundamental role, via hypothalamic microinflammation, in translating overnutrition and aging into complex outcomes. Here we summarize recent work and suggest a conceptual model in which hypothalamic microinflammation is a common mediator of metabolic syndrome and aging.
C1 [Tang, Yizhe; Purkayastha, Sudarshana; Cai, Dongsheng] Albert Einstein Coll Med, Dept Mol Pharmacol, Diabet Res Ctr, Inst Aging, New York, NY 10461 USA.
C3 Yeshiva University
RP Cai, DS (corresponding author), Albert Einstein Coll Med, Dept Mol Pharmacol, Diabet Res Ctr, Inst Aging, New York, NY 10461 USA.
EM dongsheng.cai@einstein.yu.edu
RI Cai, Dongsheng/CAH-8271-2022; Tang, Yizhe/A-8682-2014
OI Tang, Yizhe/0000-0001-5354-478X
FU NIH [R01 DK078750, R01 AG031774, R01 HL113180]
FX The authors sincerely thank Cai's laboratory members for conducting
   research related to this topic, supported by NIH R01 DK078750, R01
   AG031774 and R01 HL113180 (all to D. Cai).
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NR 147
TC 75
Z9 84
U1 0
U2 34
PU ELSEVIER SCIENCE LONDON
PI LONDON
PA 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND
SN 0166-2236
EI 1878-108X
J9 TRENDS NEUROSCI
JI Trends Neurosci.
PD JAN
PY 2015
VL 38
IS 1
BP 36
EP 44
DI 10.1016/j.tins.2014.10.002
PG 9
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA AY9IA
UT WOS:000347862600005
PM 25458920
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Kongsted, AH
   Husted, SV
   Thygesen, MP
   Christensen, VG
   Blache, D
   Tolver, A
   Larsen, T
   Quistorff, B
   Nielsen, MO
AF Kongsted, Anna H.
   Husted, Sanne V.
   Thygesen, Malin P.
   Christensen, Vibeke G.
   Blache, Dominique
   Tolver, Anders
   Larsen, Torben
   Quistorff, Bjorn
   Nielsen, Mette O.
TI Pre- and postnatal nutrition in sheep affects β-cell secretion and
   hypothalamic control
SO JOURNAL OF ENDOCRINOLOGY
LA English
DT Article
DE prenatal programming; obesity; fasting; propionate tolerance test;
   gluconeogenesis; glucose; insulin; IGF1; leptin; cortisol
ID INSULIN-RESISTANCE-SYNDROME; PROPIONATE LOADING TEST; METABOLIC
   SYNDROME; GROWTH-HORMONE; LIVER-FUNCTION; BIRTH-WEIGHT; ADULTHOOD;
   CORTISOL; OBESITY; LEPTIN
AB Maternal undernutrition increases the risk of type 2 diabetes and metabolic syndrome later in life, particularly upon postnatal exposure to a high-energy diet. However, dysfunctions of, for example, the glucose-insulin axis are not readily detectable by conventional tests early in life, making it difficult to identify individuals at risk. Thus, other methods are required. We hypothesised that prenatally undernourished individuals (but not postnatally overnourished ones) are adapted to a life with limited food availability, which would be evident under conditions reflecting starvation, stress and short-term abundance of food. In this study, twin-pregnant sheep were fed diets meeting 100% (NORM) or 50%(LOW) of energy and protein requirements during the last trimester. Twin offspring were fed either a normal moderate (CONV) diet or a high-carbohydrate-high-fat (HCHF) diet from 3 days to 6 months of age (approximately puberty) and the same moderate diet thereafter until 2 years of age (young adulthood; only females), resulting in four groups: NORM-CONV, LOW-CONV, NORM-HCHF and LOW-HCHF. At the age of 6 months and 2 years respectively, they were subjected to fasting and propionate (nutrient abundance) and adrenalin challenges. At 6 months of age, postnatal HCHF diet exposure caused metabolic alterations, reflecting hypertriglyceridaemia and altered pancreatic beta-cell secretion. Irrespective of postnatal diet, prenatal undernutrition was found to be associated with unexpected endocrine responses of leptin, IGF1 and cortisol during fasting (lack of or the opposite response compared with the controls) in 2-year-old adults. In conclusion, a HCHF diet interfered with b-cell function, whereas maternal undernutrition did not lead to any changes in the LOW off spring, except to abnormal hormone responses, suggesting that fetal programming interferes with hypothalamic integration of important endocrine axis.
C1 [Kongsted, Anna H.; Husted, Sanne V.; Christensen, Vibeke G.; Nielsen, Mette O.] Univ Copenhagen, Dept Vet Clin & Anim Sci, Fac Hlth & Med Sci, Copenhagen, Denmark.
   [Thygesen, Malin P.] Cook Med Europe APS, Bjaeverskov, Denmark.
   [Blache, Dominique] Univ Western Australia, Sch Anim Biol, Perth, WA 6009, Australia.
   [Tolver, Anders] Univ Copenhagen, Fac Hlth & Med Sci, Dept Basic Sci & Environm, Copenhagen, Denmark.
   [Larsen, Torben] Aarhus Univ, Dept Anim Sci, Fac Sci & Technol, Aarhus, Denmark.
   [Quistorff, Bjorn] Univ Copenhagen, Nucl Magnet Resonance Ctr, Fac Hlth & Med Sci, Dept Biomed Sci, Copenhagen, Denmark.
C3 University of Copenhagen; University of Western Australia; University of
   Copenhagen; Aarhus University; University of Copenhagen
RP Kongsted, AH (corresponding author), Univ Copenhagen, Dept Vet Clin & Anim Sci, Fac Hlth & Med Sci, Copenhagen, Denmark.
EM ahtp@sund.ku.dk
RI Larsen, Torben/K-4094-2017; Nielsen, Mette/I-5822-2012; Tolver,
   Anders/A-5381-2015; Blache, Dominique/H-4991-2014
OI Blache, Dominique/0000-0003-3476-3068; Kongsted,
   Anna/0000-0003-1959-8308; Larsen, Torben/0000-0003-3058-5938
FU Danish Council for Strategic Research [09-059921, 09 067124]
FX This study was supported by the Danish Council for Strategic Research
   (grant numbers 09-059921, 09 067124).
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NR 34
TC 10
Z9 11
U1 0
U2 23
PU BIOSCIENTIFICA LTD
PI BRISTOL
PA EURO HOUSE, 22 APEX COURT WOODLANDS, BRADLEY STOKE, BRISTOL BS32 4JT,
   ENGLAND
SN 0022-0795
EI 1479-6805
J9 J ENDOCRINOL
JI J. Endocrinol.
PD NOV
PY 2013
VL 219
IS 2
BP 159
EP 171
DI 10.1530/JOE-13-0099
PG 13
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 242YD
UT WOS:000326281400009
PM 24096964
OA Bronze
DA 2025-06-11
ER

PT J
AU Eapen, V
   Mabrouk, A
   Yousef, S
AF Eapen, Valsamma
   Mabrouk, AbdulAzim
   Yousef, Saeed
TI Metabolic Syndrome among the Young Obese in the United Arab Emirates
SO JOURNAL OF TROPICAL PEDIATRICS
LA English
DT Article
DE metabolic syndrome; depression; children and Adolescents; Arab
   population
ID 3RD NATIONAL-HEALTH; DIABETES-MELLITUS; PREVALENCE; ADOLESCENTS;
   DEPRESSION; OVERWEIGHT; FREQUENCY
AB Obesity is the sixth major risk factor for the overall burden of disease globally, and is associated with a constellation of metabolic derangements starting early in life. Features of metabolic syndrome (MS) were assessed among obese young individuals in the UAE. Of the 260 obese young people screened, 44% were found to have MS. Prevalence of MS was more among boys than girls and there was a significant association with a positive family history of obesity, diabetes or hypertension. Subjective report of psychological distress was found in 95%, and significant depressive symptoms were present among three-quarters of those with MS. The prevalence and magnitude of obesity and its sequelae including MS is increasing world wide, and newly modernized countries are particularly at risk. Child health professionals must be aware of this and attempts should be made for early identification and necessary intervention including attention to psychological issues.
C1 [Eapen, Valsamma] Univ New S Wales, Dept Psychiat, Sydney, NSW 2052, Australia.
   [Yousef, Saeed] UAE Univ, Dept Psychiat, Al Ain, U Arab Emirates.
C3 University of New South Wales Sydney; United Arab Emirates University
RP Eapen, V (corresponding author), Liverpool Hosp, Mental Hlth Ctr, UNSWICAMHS, L1,Elizabeth St, Liverpool, NSW 2170, Australia.
EM v.eapen@unsw.edu.au
RI Eapen, Valsamma/N-9608-2017
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   *WHO, 2004, MENT HLTH ATL COUNTR
NR 21
TC 16
Z9 17
U1 0
U2 3
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0142-6338
EI 1465-3664
J9 J TROP PEDIATRICS
JI J. Trop. Pediatr.
PD OCT
PY 2010
VL 56
IS 5
BP 325
EP 328
DI 10.1093/tropej/fmp128
PG 4
WC Pediatrics; Tropical Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics; Tropical Medicine
GA 662OL
UT WOS:000282817400007
PM 20032259
OA Bronze
DA 2025-06-11
ER

PT J
AU Willson, C
   Watanabe, M
   Tsuji-Hosokawa, A
   Makino, A
AF Willson, Conor
   Watanabe, Makiko
   Tsuji-Hosokawa, Atsumi
   Makino, Ayako
TI Pulmonary vascular dysfunction in metabolic syndrome
SO JOURNAL OF PHYSIOLOGY-LONDON
LA English
DT Review
DE pulmonary artery; Diabetes; Insulin resistance; obesity; dyslipidemia;
   pulmonary hypertension
ID DENSITY-LIPOPROTEIN CHOLESTEROL; ENDOTHELIAL GROWTH-FACTOR;
   PROTEIN-KINASE-C; MUSCLE-CELL PROLIFERATION; MESENTERIC ARTERIAL BED;
   TYPE-1 DIABETIC MICE; OXIDATIVE STRESS; NITRIC-OXIDE; HEART-FAILURE;
   INFLAMMATORY CYTOKINES
AB Metabolic syndrome is a critically important precursor to the onset of many diseases, such as cardiovascular disease, and cardiovascular disease is the leading cause of death worldwide. The primary risk factors of metabolic syndrome include hyperglycaemia, abdominal obesity, dyslipidaemia, and high blood pressure. It has been well documented that metabolic syndrome alters vascular endothelial and smooth muscle cell functions in the heart, brain, kidney and peripheral vessels. However, there is less information available regarding how metabolic syndrome can affect pulmonary vascular function and ultimately increase an individual's risk of developing various pulmonary vascular diseases, such as pulmonary hypertension. Here, we review in detail how metabolic syndrome affects pulmonary vascular function.
C1 [Willson, Conor; Watanabe, Makiko; Tsuji-Hosokawa, Atsumi; Makino, Ayako] Univ Arizona, Dept Physiol, 1501 N Campbell Ave,POB 245051, Tucson, AZ 85724 USA.
C3 University of Arizona
RP Makino, A (corresponding author), Univ Arizona, Dept Physiol, 1501 N Campbell Ave,POB 245051, Tucson, AZ 85724 USA.
EM aymakino@email.arizona.edu
RI ; Tsuji-Hosokawa, Atsumi/Q-7378-2018
OI Willson, Conor/0000-0003-3981-4290; Tsuji-Hosokawa,
   Atsumi/0000-0001-8226-2618
FU National Heart, Lung, and Heart Institute of the National Institutes of
   Health [HL142214]
FX This work was supported by a grant from the National Heart, Lung, and
   Heart Institute of the National Institutes of Health (HL142214 to A.
   Makino).
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NR 264
TC 19
Z9 20
U1 0
U2 10
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-3751
EI 1469-7793
J9 J PHYSIOL-LONDON
JI J. Physiol.-London
PD FEB 15
PY 2019
VL 597
IS 4
BP 1121
EP 1141
DI 10.1113/JP275856
PG 21
WC Neurosciences; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Physiology
GA HL4GY
UT WOS:000458676000019
PM 30125956
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Skiveren, J
   Philipsen, P
   Therming, G
AF Skiveren, J.
   Philipsen, P.
   Therming, G.
TI Patients with psoriasis have insufficient knowledge of their risk of
   atherothrombotic disease and metabolic syndrome
SO CLINICAL AND EXPERIMENTAL DERMATOLOGY
LA English
DT Article
AB Background Knowledge is crucial to allow patients to increase their level of self-care.
   Objectives To examine the extent to which patients with moderate to severe psoriasis feel informed about their disease, to investigate their level of knowledge about psoriasis and the associated risk of atherothrombotic disease and metabolic syndrome, and to assess the importance of the kind of treatment received and of membership of a patients' association.
   Methods In total, 218 patients with psoriasis (mean age 45.5years, range 18-83), who were being treated with methotrexate or biological drugs responded to a questionnaire.
   Results Patients were well informed about their skin disease, but were less well informed about their risk of atherothrombotic disease/metabolic syndrome (visual analogue scale values of 6.91 and 5.15, respectively). Patients' knowledge of the disease was reflected by 74.2-99.1% correct answers (CA). The risk of arthritis elicited 88% CA and of depression 41.7% CA, while the risk of atherothrombotic disease and metabolic syndrome produced only 11.9-15.3% CA. Patients treated with biological drugs had a significantly stronger sense of being more well informed about the risk of disease (P=0.02) and their risks (P<0.001) compared with patients treated with methotrexate. Members of a patients' association had significantly more knowledge than nonmembers about the risk of depression (P=0.01), hypertension (P=0.001), diabetes mellitus (P=0.01) and obesity (P=0.04).
   Conclusions This study shows that few patients with moderate to severe psoriasis are aware of their increased risk of atherothrombotic disease and metabolic syndrome. This indicates the need for patients to be offered education concerning the risk and prevention of atherothrombotic disease and metabolic syndrome.
C1 [Skiveren, J.; Philipsen, P.; Therming, G.] Univ Copenhagen, Bispebjerg Hosp, Dept Dermatol, Copenhagen, Denmark.
   [Skiveren, J.; Philipsen, P.; Therming, G.] Univ Copenhagen, Dept Dermatol, Bispebjerg Hosp, DK-2400 Copenhagen NV, Denmark.
C3 University of Copenhagen; Bispebjerg Hospital; Copenhagen University
   Hospital; University of Copenhagen; Copenhagen University Hospital;
   Bispebjerg Hospital
RP Skiveren, J (corresponding author), Univ Copenhagen, Dept Dermatol, Bispebjerg Hosp, Bispebjerg Bakke 23, DK-2400 Copenhagen NV, Denmark.
EM jski0001@regionh.dk
OI Philipsen, Peter Alshede/0000-0002-9656-733X
CR Ahlehoff O, 2011, J INTERN MED, V270, P147, DOI 10.1111/j.1365-2796.2010.02310.x
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NR 14
TC 13
Z9 15
U1 0
U2 4
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0307-6938
EI 1365-2230
J9 CLIN EXP DERMATOL
JI Clin. Exp. Dermatol.
PD AUG
PY 2015
VL 40
IS 6
BP 600
EP 604
DI 10.1111/ced.12628
PG 5
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA CN1RP
UT WOS:000358198100002
PM 25847319
DA 2025-06-11
ER

PT J
AU Tabur, S
   Oguz, E
   Eren, MA
   Korkmaz, H
   Savas, E
   Aksoy, N
   Sabuncu, T
AF Tabur, Suzan
   Oguz, Elif
   Eren, Mehmet Ali
   Korkmaz, Hakan
   Savas, Esen
   Aksoy, Nurten
   Sabuncu, Tevfik
TI Serum prolidase activity is associated with non-diabetic metabolic
   syndrome
SO DIABETOLOGY & METABOLIC SYNDROME
LA English
DT Article
DE Metabolic syndrome; Non-diabetic; Obesity; Prolidase
ID MATRIX METALLOPROTEINASES; OXIDATIVE STRESS; TISSUE INHIBITOR;
   ADIPOSE-TISSUE; OBESE CHILDREN; HIGH GLUCOSE;
   MATRIX-METALLOPROTEINASE-9; ATHEROSCLEROSIS; MARKERS; ENZYME
AB Objective: The aim of this study was to determine the role of serum prolidase activity and the possible association with oxidative stress parameters in non-diabetic metabolic syndrome.
   Methods: 30 obese patients without metabolic syndrome (MetS), 34 non-diabetic obese patients with MetS, and 23 volunteer control subjects were enrolled in the study. Fasting plasma glucose (FPG), plasma glucose following 75 g glucose administration, high-density lipoprotein-cholesterol (HDL-C), high-density lipoprotein-cholesterol (LDL-C), total cholesterol, triglyceride (TG), total antioxidant status (TAS), total oxidative status (TOS), oxidative stress index (OSI), and prolidase activities of all subjects were analyzed.
   Results: Prolidase levels was significantly higher in MetS group compared to both obese and control groups (p < 0.001 and p < 0.05 respectively). Prolidase was also higher in the obese group than in the control group (p < 0.05). Prolidase was negatively correlated with TAS and HDL-C (r = -0,362, p < 0.001; r = -0.320, p < 0.01, respectively) and positively correlated with BMI, weight, waist-c, SBP, DBP, TG, TC, LDL-C.
   Conclusion: Prolidase activity may have a role in the pathogenesis of metabolic syndrome.
C1 [Tabur, Suzan; Korkmaz, Hakan] Gaziantep Univ, Dept Internal Med, Fac Med, Div Endocrinol, TR-27100 Sahinbey, Gaziantep, Turkey.
   [Oguz, Elif] Harran Univ, Dept Med Pharmacol, Fac Med, TR-63300 Sanliurfa, Turkey.
   [Eren, Mehmet Ali; Sabuncu, Tevfik] Harran Univ, Div Endocrinol, Dept Internal Med, Fac Med, TR-63300 Sanliurfa, Turkey.
   [Savas, Esen] Gaziantep Univ, Dept Internal Med, Fac Med, TR-27100 Sahinbey, Gaziantep, Turkey.
   [Aksoy, Nurten] Harran Univ, Dept Clin Biochem, Fac Med, TR-63300 Sanliurfa, Turkey.
C3 Gaziantep University; Harran University; Harran University; Gaziantep
   University; Harran University
RP Korkmaz, H (corresponding author), Gaziantep Univ, Dept Internal Med, Fac Med, Div Endocrinol, TR-27100 Sahinbey, Gaziantep, Turkey.
EM drhkorkmaz@yahoo.com.tr
RI eren, mehmet/ABH-7279-2020; Inan, Nurten/AAA-8197-2021; Sabuncu,
   Tevfik/ABF-5291-2020; Oguz, Elif/KCZ-1767-2024
OI OGUZ, ELIF/0000-0002-8052-671X
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NR 39
TC 7
Z9 9
U1 0
U2 9
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1758-5996
J9 DIABETOL METAB SYNDR
JI Diabetol. Metab. Syndr.
PD DEC 17
PY 2014
VL 6
AR 142
DI 10.1186/1758-5996-6-142
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA AX4AD
UT WOS:000346875700001
PM 25540672
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Houschyar, KS
   Lüdtke, R
   Dobos, GJ
   Kalus, U
   Broecker-Preuss, M
   Rampp, T
   Brinkhaus, B
   Michalsen, A
AF Houschyar, Khosrow S.
   Luedtke, Rainer
   Dobos, Gustav J.
   Kalus, Ulrich
   Broecker-Preuss, Martina
   Rampp, Thomas
   Brinkhaus, Benno
   Michalsen, Andreas
TI Effects of phlebotomy-induced reduction of body iron stores on metabolic
   syndrome: results from a randomized clinical trial
SO BMC MEDICINE
LA English
DT Article
ID INSULIN-RESISTANCE SYNDROME; SERUM FERRITIN; BLOOD-PRESSURE; MEN;
   HYPERTENSION; PREVALENCE; HEMOCHROMATOSIS; ASSOCIATION; TRANSFERRIN;
   SENSITIVITY
AB Background: Metabolic syndrome (METS) is an increasingly prevalent but poorly understood clinical condition characterized by insulin resistance, glucose intolerance, dyslipidemia, hypertension, and obesity. Increased oxidative stress catalyzed by accumulation of iron in excess of physiologic requirements has been implicated in the pathogenesis of METS, but the relationships between cause and effect remain uncertain. We tested the hypothesis that phlebotomy-induced reduction of body iron stores would alter the clinical presentation of METS, using a randomized trial.
   Methods: In a randomized, controlled, single-blind clinical trial, 64 patients with METS were randomly assigned to iron reduction by phlebotomy (n = 33) or to a control group (n = 31), which was offered phlebotomy at the end of the study (waiting-list design). The iron-reduction patients had 300 ml of blood removed at entry and between 250 and 500 ml removed after 4 weeks, depending on ferritin levels at study entry. Primary outcomes were change in systolic blood pressure (SBP) and insulin sensitivity as measured by Homeostatic Model Assessment (HOMA) index after 6 weeks. Secondary outcomes included HbA1c, plasma glucose, blood lipids, and heart rate (HR).
   Results: SBP decreased from 148.5 +/- 12.3 mmHg to 130.5 +/- 11.8 mmHg in the phlebotomy group, and from 144.7 +/- 14.4 mmHg to 143.8 +/- 11.9 mmHg in the control group (difference -16.6 mmHg; 95% CI -20.7 to -12.5; P < 0.001). No significant effect on HOMA index was seen. With regard to secondary outcomes, blood glucose, HbA1c, low-density lipoprotein/high-density lipoprotein ratio, and HR were significantly decreased by phlebotomy. Changes in BP and HOMA index correlated with ferritin reduction.
   Conclusions: In patients with METS, phlebotomy, with consecutive reduction of body iron stores, lowered BP and resulted in improvements in markers of cardiovascular risk and glycemic control. Blood donation may have beneficial effects for blood donors with METS.
C1 [Brinkhaus, Benno; Michalsen, Andreas] Charite Univ Med Ctr, Inst Social Med Epidemiol & Hlth Econ, Berlin, Germany.
   [Houschyar, Khosrow S.; Dobos, Gustav J.; Rampp, Thomas] Univ Duisburg Essen, Kliniken Essen Mitte, Dept Internal Med, Essen, Germany.
   [Luedtke, Rainer] Karl & Veronica Carstens Fdn, Dept Biometry, Essen, Germany.
   [Kalus, Ulrich] Charite Univ Med Ctr, Inst Transfus Med, Berlin, Germany.
   [Broecker-Preuss, Martina] Univ Hosp Essen, Dept Endocrinol, Essen, Germany.
   [Broecker-Preuss, Martina] Univ Hosp Essen, Div Lab Res, Essen, Germany.
   [Michalsen, Andreas] Immanuel Hosp Berlin, Dept Internal & Integrat Med, D-14109 Berlin, Germany.
C3 Berlin Institute of Health; Free University of Berlin; Humboldt
   University of Berlin; Charite Universitatsmedizin Berlin; Kliniken
   Essen-Mitte; University of Duisburg Essen; Berlin Institute of Health;
   Free University of Berlin; Humboldt University of Berlin; Charite
   Universitatsmedizin Berlin; University of Duisburg Essen; University of
   Duisburg Essen
RP Michalsen, A (corresponding author), Charite Univ Med Ctr, Inst Social Med Epidemiol & Hlth Econ, Berlin, Germany.
EM a.michalsen@immanuel.de
RI Brinkhaus, Benno/AAU-2428-2021; Bröcker-Preuß, Martina/KPB-0300-2024
OI Brinkhaus, Benno/0000-0001-6290-744X; Kalus, Ulrich/0000-0001-9147-9851
FU Karl and Veronica Carstens Foundation, Essen, Germany
FX The study was funded by a grant from the Karl and Veronica Carstens
   Foundation, Essen, Germany.
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NR 37
TC 113
Z9 125
U1 0
U2 25
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1741-7015
J9 BMC MED
JI BMC Med.
PD MAY 30
PY 2012
VL 10
AR 54
DI 10.1186/1741-7015-10-54
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 967OG
UT WOS:000305917100001
PM 22647517
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Soyal, SM
   Nofziger, C
   Dossena, S
   Paulmichl, M
   Patsch, W
AF Soyal, Selma M.
   Nofziger, Charity
   Dossena, Silvia
   Paulmichl, Markus
   Patsch, Wolfgang
TI Targeting SREBPs for treatment of the metabolic syndrome
SO TRENDS IN PHARMACOLOGICAL SCIENCES
LA English
DT Review
DE metabolic syndrome; insulin resistance; SREBPs; SREBP inhibitors
ID ELEMENT-BINDING PROTEIN-1C; ENDOPLASMIC-RETICULUM STRESS;
   INSULIN-RESISTANCE; HEPATIC STEATOSIS; ADIPOSE-TISSUE; LIPID-METABOLISM;
   ER STRESS; IMPROVES HYPERLIPIDEMIA; CHOLESTEROL-METABOLISM;
   LIPOPROTEIN-LIPASE
AB Over the past few decades, mortality resulting from cardiovascular disease (CVD) steadily decreased in western countries; however, in recent years, the decline has become offset by the increase in obesity. Obesity is strongly associated with the metabolic syndrome and its atherogenic dyslipidemia resulting from insulin resistance. While lifestyle treatment would be effective, drugs targeting individual risk factors are often required. Such treatment may result in polypharmacy. Novel approaches are directed towards the treatment of several risk factors with one drug. Studies in animal models and humans suggest a central role for sterol regulatory-element binding proteins (SREBPs) in the pathophysiology of the metabolic syndrome. Four recent studies targeting the maturation or transcriptional activities of SREBPs provide proof of concept for the efficacy of SREBP inhibition in this syndrome.
C1 [Soyal, Selma M.; Nofziger, Charity; Dossena, Silvia; Paulmichl, Markus; Patsch, Wolfgang] Paracelsus Med Univ, Inst Pharmacol & Toxicol, Salzburg, Austria.
C3 Paracelsus Private Medical University
RP Patsch, W (corresponding author), Paracelsus Med Univ, Inst Pharmacol & Toxicol, Salzburg, Austria.
EM wolfgang.patsch@pmu.ac.at
RI Dossena, Silvia/G-1437-2018; Nofziger, Charity/LDG-5780-2024
OI Dossena, Silvia/0000-0002-6694-9249
FU Fonds zur Forderung der wissenschaftlichen Forschung (FWF) [P19893];
   Paracelsus Medical University Salzburg; FWF [V344-B24]; Roche Postdoc
   Fellowship Program [231]; Austrian Science Fund (FWF) [V344, P19893]
   Funding Source: Austrian Science Fund (FWF)
FX This work was supported by grants from the Fonds zur Forderung der
   wissenschaftlichen Forschung (FWF Project P19893) and from Paracelsus
   Medical University Salzburg to W.P. S.M.S. is supported by the FWF
   project Nr. V344-B24. C.N. is supported by the Roche Postdoc Fellowship
   Program (#231).
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NR 103
TC 75
Z9 84
U1 0
U2 32
PU ELSEVIER SCIENCE LONDON
PI LONDON
PA 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND
SN 0165-6147
EI 1873-3735
J9 TRENDS PHARMACOL SCI
JI Trends Pharmacol. Sci.
PD JUN
PY 2015
VL 36
IS 6
BP 406
EP 416
DI 10.1016/j.tips.2015.04.010
PG 11
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA CL0MN
UT WOS:000356636900009
PM 26005080
DA 2025-06-11
ER

PT J
AU Narnikoshi, T
   Tomita, N
   Satoh, M
   Haruna, Y
   Kobayashi, S
   Komai, N
   Sasaki, T
   Kashihara, N
AF Narnikoshi, Tamehachi
   Tomita, Naruya
   Satoh, Minoru
   Haruna, Yoshisuke
   Kobayashi, Shinya
   Komai, Norio
   Sasaki, Tamaki
   Kashihara, Naoki
TI Olmesartan ameliorates renovascular injury and oxidative stress in
   Zucker obese rats enhanced by dietary protein
SO AMERICAN JOURNAL OF HYPERTENSION
LA English
DT Article
DE metabolic syndrome; Zucker obese rats; oxidative stress; renovascular
   injury; dietary protein
ID CHRONIC KIDNEY-DISEASE; II TYPE-1 RECEPTOR; METABOLIC SYNDROME; NAD(P)H
   OXIDASE; IN-VIVO; ENDOTHELIAL DYSFUNCTION; RENAL INJURY;
   GLOMERULOSCLEROSIS; SUPEROXIDE; EVENTS
AB Background: The metabolic syndrome is a risk factor for the development of renal and vascular complications. Dietary protein intake aggravates renal injury in Zucker obese rats, a model of the metabolic syndrome. This study investigated whether dietary protein intake enhances renal and vascular injuries by oxidative stress, and assessed effects of olmesartan, an angiotensin 11 type 1 receptor blocker, in this model.
   Methods: Zucker obese rats were fed either a standard protein diet, high protein diet (OHP), or high protein diet containing olmesartan or hydralazine for 12 weeks. We examined the glomerulosclerosis score, endothelium-dependent relaxation response in the aorta, 4-hydroxy-2-nonenal (HNE) contents in the kidney and aorta, and mRNA expression of NAD(P)H oxidase components (p22phox and p47phox) in the renal cortex.
   Results, The OHP rats developed proteinuria, glomerulosclerosis, and endothelial dysfunction. Olmesartan prevented the development of all these damages in OHP rats, whereas hydralazine improved only glomerulosclerosis. The high protein diet also augmented HNE accumulation in glomeruli, renal arteries, and aortas, and increased the mRNA expressions of p22phox and p47phox in the renal cortex in obese rats. Olmesartan, but not hydralazine, inhibited all these changes.
   Conclusions: These results suggested that increased dietary protein intake exacerbates renal and vascular injuries, and augments oxidative stress in a rat model of the metabolic syndrome. Olmesartan ameliorated these injuries, presumably through its antioxidative effects, whereas hydralazine improved only glomerulosclerosis through its antihypertensive action. Dietary protein-enhanced injuries in the metabolic syndrome may be associated with hypercholesterolemia and the activated renin-angiotensin system.
C1 Kawasaki Med Sch, Dept Internal Med, Div Nephrol, Kurashiki, Okayama 7010192, Japan.
C3 Kawasaki Medical School
RP Tomita, N (corresponding author), Kawasaki Med Sch, Dept Internal Med, Div Nephrol, 577 Matsushima, Kurashiki, Okayama 7010192, Japan.
EM tomita@med.kawasaki-m.ac.jp
RI Satoh, Minoru/E-2421-2011
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NR 30
TC 35
Z9 37
U1 0
U2 1
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0895-7061
EI 1941-7225
J9 AM J HYPERTENS
JI Am. J. Hypertens.
PD OCT
PY 2007
VL 20
IS 10
BP 1085
EP 1091
DI 10.1016/j.amjhyper.2007.05.007
PG 7
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 223SC
UT WOS:000250391600010
PM 17903692
DA 2025-06-11
ER

PT J
AU Sebeková, K
   Staruchová, M
   Mislanová, C
   Lísková, A
   Horváthová, M
   Tulinská, J
   Mikusová, ML
   Szabová, M
   Gurecká, R
   Koborová, I
   Csongová, M
   Tábi, T
   Szökö, E
   Volkovová, K
AF Sebekova, Katarina
   Staruchova, Marta
   Mislanova, Csilla
   Liskova, Aurelia
   Horvathova, Mira
   Tulinska, Jana
   Lehotska Mikusova, Miroslava
   Szabova, Michaela
   Gurecka, Radana
   Koborova, Ivana
   Csongova, Melinda
   Tabi, Tamas
   Szoko, Eva
   Volkovova, Katarina
TI Association of Inflammatory and Oxidative Status Markers with Metabolic
   Syndrome and Its Components in 40-to-45-Year-Old Females: A
   Cross-Sectional Study
SO ANTIOXIDANTS
LA English
DT Article
DE cardiometabolic risk markers; uric acid; bilirubin; antioxidative
   enzymes; sRAGE; cellular adhesion molecules
ID GLYCATION END-PRODUCTS; PERFORMANCE LIQUID-CHROMATOGRAPHY; URIC-ACID;
   AMINE OXIDASE; ASYMPTOMATIC HYPERURICEMIA; INSULIN-RESISTANCE;
   ANTIOXIDANT STATUS; PROVISIONAL REPORT; MAILLARD REACTION; RISK-FACTORS
AB Oxidative stress and sterile inflammation play roles in the induction and maintenance of metabolic syndrome (MetS). This study cohort included 170 females aged 40 to 45 years who were categorized according to the presentation of MetS components (e.g., central obesity, insulin resistance, atherogenic dyslipidemia, and elevated systolic blood pressure) as controls not presenting a single component (n = 43), those with pre-MetS displaying one to two components (n = 70), and females manifesting MetS, e.g., & GE;3 components (n = 53). We analyzed the trends of seventeen oxidative and nine inflammatory status markers across three clinical categories. A multivariate regression of selected oxidative status and inflammatory markers on the components of MetS was performed. Markers of oxidative damage (malondialdehyde and advanced-glycation-end-products-associated fluorescence of plasma) were similar across the groups. Healthy controls displayed lower uricemia and higher bilirubinemia than females with MetS; and lower leukocyte counts, concentrations of C-reactive protein, interleukine-6, and higher levels of carotenoids/lipids and soluble receptors for advanced glycation end-products than those with pre-MetS and MetS. In multivariate regression models, levels of C-reactive protein, uric acid, and interleukine-6 were consistently associated with MetS components, although the impacts of single markers differed. Our data suggest that a proinflammatory imbalance precedes the manifestation of MetS, while an imbalance of oxidative status accompanies overt MetS. Further studies are needed to elucidate whether determining markers beyond traditional ones could help improve the prognosis of subjects at an early stage of MetS.
C1 [Sebekova, Katarina; Gurecka, Radana; Koborova, Ivana; Csongova, Melinda] Comenius Univ, Inst Mol Biomed, Med Fac, Bratislava 83303, Slovakia.
   [Staruchova, Marta; Volkovova, Katarina] Slovak Med Univ Bratislava, Inst Biol, Med Fac, Bratislava 83303, Slovakia.
   [Mislanova, Csilla] Slovak Med Univ Bratislava, Inst Nutr, Fac Nursing & Med Profess Studies, Bratislava 83303, Slovakia.
   [Liskova, Aurelia; Horvathova, Mira; Tulinska, Jana; Lehotska Mikusova, Miroslava; Szabova, Michaela] Slovak Med Univ Bratislava, Dept Immunol & Immunotoxicol, Bratislava 83303, Slovakia.
   [Gurecka, Radana] Comenius Univ, Inst Med Phys Biophys Informat & Telemed, Fac Med, Bratislava 83303, Slovakia.
   [Tabi, Tamas; Szoko, Eva] Semmelweis Univ, Fac Pharm, Dept Pharmacodynam, H-1085 Budapest, Hungary.
C3 Comenius University Bratislava; Slovak Medical University Bratislava;
   Slovak Medical University Bratislava; Slovak Medical University
   Bratislava; Comenius University Bratislava; Semmelweis University
RP Sebeková, K (corresponding author), Comenius Univ, Inst Mol Biomed, Med Fac, Bratislava 83303, Slovakia.
EM katarina.sebekova@imbm.sk; marta.staruchova@szu.sk;
   csilla.mislanova@szu.sk; aurelia.liskova@szu.sk; mira.horvathova@szu.sk;
   jana.tulinska@szu.sk; miroslava.mikusova@szu.sk;
   michaela.szabova@szu.sk; radana.kollarova@gmail.com; koborova@gmail.com;
   melinda.csongova@gmail.com; tabi.tamas@pharma.semmelweis-uni.hu;
   eva.szoko@pharma.semmelweis-uni.hu; katarina.volkovova@szu.sk
RI Tábi, Tamás/O-2960-2017; Gurecka, Radana/AAX-6744-2021; Horvathova,
   Mira/JLM-8505-2023; Csongová, Melinda/AAJ-8811-2020; Mišľanová,
   Csilla/HLQ-1069-2023; Sebekova, Katarina/GSD-7056-2022; Tulinska,
   Jana/ABC-3359-2021; Sebekova, Katarina/H-4906-2016; Lehotska Mikusova,
   Miroslava/ABB-8260-2021
OI Horvathova, Mira/0000-0002-3264-0980; Sebekova,
   Katarina/0000-0002-9641-9265; Lehotska Mikusova,
   Miroslava/0000-0002-5819-2418; Szabova, Michaela/0000-0001-7459-214X;
   Gurecka, Radana/0000-0002-5880-666X; Tulinska, Jana/0000-0001-9661-8654
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NR 117
TC 4
Z9 5
U1 1
U2 5
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD JUN
PY 2023
VL 12
IS 6
AR 1221
DI 10.3390/antiox12061221
PG 19
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA K1AM3
UT WOS:001013840500001
PM 37371951
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Battelli, MG
   Bortolotti, M
   Polito, L
   Bolognesi, A
AF Battelli, Maria Giulia
   Bortolotti, Massimo
   Polito, Letizia
   Bolognesi, Andrea
TI Metabolic syndrome and cancer risk: The role of xanthine oxidoreductase
SO REDOX BIOLOGY
LA English
DT Review
DE Cancer risk; Inflammation; Metabolic syndrome; Oncogenesis; Oxidative
   stress; Xanthine oxidoreductase
ID URIC-ACID; INSULIN-RESISTANCE; OXIDASE ACTIVITY; CARDIOVASCULAR-DISEASE;
   INFLAMMATION; REDUCTION; IMBALANCE; FRUCTOSE
AB Obesity and related pathologies such as diabetes and metabolic syndrome are associated with chronic inflammation and cancer. The serum level of xanthine oxidoreductase (XOR) is correlated to obesity-associated metabolic disorders. XOR can play a role in the pathogenesis of both metabolic syndrome and cancer through the inflammatory response and the oxidative stress elicited by the products of its activity. The reactive oxygen and nitrogen species and the uric acid derived from XOR concur to the development of hypertension, dyslipidemia and insulin resistance and participate in both cell transformation and proliferation, as well as in the progression and metastasis process. Despite the availability of different drugs to inhibit in vivo XOR activity, the complexity of XOR inhibition effects should be carefully considered before clinical application, save in the case of symptomatic hyperuricemia.
C1 [Battelli, Maria Giulia; Bortolotti, Massimo; Polito, Letizia; Bolognesi, Andrea] Univ Bologna, Dept Expt Diagnost & Specialty Med DIMES, Alma Mater Studiorum, Via San Giacomo 14, I-40126 Bologna, Italy.
C3 University of Bologna
RP Polito, L (corresponding author), Univ Bologna, Dept Expt Diagnost & Specialty Med DIMES, Alma Mater Studiorum, Via San Giacomo 14, I-40126 Bologna, Italy.
EM mariagiulia.battelli@unibo.it; massimo.bortolotti2@unibo.it;
   letizia.polito@unibo.it; andrea.bolognesi@unibo.it
RI Bolognesi, Andrea/Q-6526-2017; Battelli, Maria Giulia/G-2711-2015;
   BORTOLOTTI, MASSIMO/E-1822-2011; Polito, Letizia/H-2877-2019
OI Bolognesi, Andrea/0000-0001-7497-4586; Battelli, Maria
   Giulia/0000-0001-6048-0454; BORTOLOTTI, MASSIMO/0000-0001-9030-2237;
   Polito, Letizia/0000-0001-8051-4981
FU Alma Mater Studiorum - University of Bologna; Pallotti Legacies for
   Cancer Research
FX This work was supported by funds for selected research topics from the
   Alma Mater Studiorum - University of Bologna and by the Pallotti
   Legacies for Cancer Research.
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NR 52
TC 82
Z9 90
U1 2
U2 19
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2213-2317
J9 REDOX BIOL
JI Redox Biol.
PD FEB
PY 2019
VL 21
AR 101070
DI 10.1016/j.redox.2018.101070
PG 6
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA HR1WN
UT WOS:000462926900012
PM 30576922
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Herouvi, D
   Paltoglou, G
   Soldatou, A
   Kalpia, C
   Karanasios, S
   Karavanaki, K
AF Herouvi, Despina
   Paltoglou, George
   Soldatou, Alexandra
   Kalpia, Christina
   Karanasios, Spyridon
   Karavanaki, Kyriaki
TI Lifestyle and Pharmacological Interventions and Treatment Indications
   for the Management of Obesity in Children and Adolescents
SO CHILDREN-BASEL
LA English
DT Review
DE children; adolescents; childhood obesity; treatment; lifestyle;
   pharmacotherapy
ID WEIGHT-LOSS; CHILDHOOD OBESITY; PHYSICAL-ACTIVITY; BODY-COMPOSITION;
   METABOLIC SYNDROME; PEDIATRIC OBESITY; DOUBLE-BLIND; RISK-FACTORS;
   ENDOTHELIAL FUNCTION; TREATING OBESITY
AB Obesity is a multifactorial chronic impairment that further decreases quality of life and life expectancy. Worldwide, childhood obesity has become a pandemic health issue causing several comorbidities that frequently present already in childhood, including cardiovascular (hypertension, dyslipidemia), metabolic (Type 2 diabetes mellitus, fatty liver disease, metabolic syndrome), respiratory, gastrointestinal and musculoskeletal disorders. In addition, obese children frequently experience stress and psychosocial symptoms, including mood disorders, anxiety, prejudice and low self-esteem. Given that cardiovascular risk factors and pediatric obesity have the tendency to pertain into adulthood, obesity management, including weight control and physical activity, should start before the late teens and certainly before the first signs of atherosclerosis can be detected. This review aims to concisely present options for childhood obesity management, including lifestyle modification strategies and pharmacological treatment, as well as the respective treatment indications for the general practitioner.
C1 [Herouvi, Despina; Paltoglou, George; Soldatou, Alexandra; Kalpia, Christina; Karanasios, Spyridon; Karavanaki, Kyriaki] Univ Athens, P&A Kyriakou Childrens Hosp, Dept Pediat 2, Diabet & Metab Clin, Athens 11527, Greece.
C3 National & Kapodistrian University of Athens
RP Paltoglou, G (corresponding author), Univ Athens, P&A Kyriakou Childrens Hosp, Dept Pediat 2, Diabet & Metab Clin, Athens 11527, Greece.
EM d.herouvi@gmail.com; gpaltoglou@gmail.com; alex_soldatou@hotmail.com;
   xrkalpia@gmail.com; spyroskara97@yahoo.gr; kkarav@yahoo.gr
RI Paltoglou, George/B-6944-2019
OI Paltoglou, George/0000-0003-4300-7061
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NR 108
TC 11
Z9 11
U1 4
U2 24
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2227-9067
J9 CHILDREN-BASEL
JI Children-Basel
PD JUL
PY 2023
VL 10
IS 7
AR 1230
DI 10.3390/children10071230
PG 16
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA N2DU5
UT WOS:001035188800001
PM 37508727
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Stark, J
   Palombo, DJ
   Hayes, JP
   Hiersche, KJ
   Hasselbach, AN
   Hayes, SM
AF Stark, Jessica
   Palombo, Daniela J.
   Hayes, Jasmeet P.
   Hiersche, Kelly J.
   Hasselbach, Alexander N.
   Hayes, Scott M.
CA Alzheimer's Dis Neuroimaging Initi
TI Partial Least Squares Regression Analysis of Alzheimer's Disease
   Biomarkers, Modifiable Health Variables, and Cognitive Change in Older
   Adults with Mild Cognitive Impairment
SO JOURNAL OF ALZHEIMERS DISEASE
LA English
DT Article
DE Episodic memory; executive function; healthy aging; inflammation;
   metabolic syndrome; neuronal plasticity; neuroprotection;
   neuropsychology
ID METABOLIC SYNDROME; EPISODIC MEMORY; COMPOSITE SCORE; CSF BIOMARKERS;
   A-BETA; DECLINE; RISK; TAU; ASSOCIATION; PREDICTION
AB Background: Prior work has shown that certain modifiable health, Alzheimer's disease (AD) biomarker, and demographic variables are associated with cognitive performance. However, less is known about the relative importance of these different domains of variables in predicting longitudinal change in cognition.
   Objective: Identify novel relationships between modifiable physical and health variables, AD biomarkers, and slope of cognitive change over two years in a cohort of older adults with mild cognitive impairment (MCI).
   Methods: Metrics of cardiometabolic risk, stress, inflammation, neurotrophic/growth factors, and AD pathology were assessed in 123 older adults with MCI at baseline from the Alzheimer's Disease Neuroimaging Initiative (mean age = 73.9; SD = 7.6; mean education = 16.0; SD = 3.0). Partial least squares regression (PLSR)-a multivariate method which creates components that best predict an outcome-was used to identify whether these physiological variables were important in predicting slope of change in episodic memory or executive function over two years.
   Results: At two-year follow-up, the two PLSR models predicted, respectively, 20.0% and 19.6% of the variance in change in episodic memory and executive function. Baseline levels of AD biomarkers were important in predicting change in both episodic memory and executive function. Baseline education and neurotrophic/growth factors were important in predicting change in episodic memory, whereas cardiometabolic variables such as blood pressure and cholesterol were important in predicting change in executive function.
   Conclusion: These data-driven analyses highlight the impact of AD biomarkers on cognitive change and further clarify potential domain specific relationships with predictors of cognitive change.
C1 [Stark, Jessica; Palombo, Daniela J.; Hiersche, Kelly J.; Hayes, Scott M.] Ohio State Univ, Dept Psychol, Columbus, OH USA.
   [Hayes, Scott M.] Ohio State Univ, Chron Brain Injury Initiat, Columbus, OH 43210 USA.
   [Hayes, Jasmeet P.] Ctr Addict & Mental Hlth, Toronto, ON, Canada.
   [Hasselbach, Alexander N.] Univ Texas Dallas, Dept Psychol, Dallas, TX USA.
C3 University System of Ohio; Ohio State University; University System of
   Ohio; Ohio State University; University of Toronto; Centre for Addiction
   & Mental Health - Canada; University of Texas System; University of
   Texas Dallas
RP Hayes, SM (corresponding author), Psychol Bldg,1835 Neil Ave, Columbus, OH 43210 USA.
EM hayes.1074@osu.edu
RI Hayes, Scott/AAL-8682-2020
OI Hayes, Scott/0000-0002-1185-5149; Stark, Jessica/0000-0003-3258-7494
FU National Institute on Aging (NIA) of the National Institutes of Health
   (NIH) [R01AG068882, R21AG056921]; Ohio State University Discovery Themes
   Chronic Brain Injury Initiative; Alzheimer's Disease Neuroimaging
   Initiative (ADNI) (National Institutes of Health) [U01AG024904]; DODADNI
   (Department of Defense) [W81XWH-12-2-0012]; National Institute on Aging;
   National Institute of Biomedical Imaging and Bioengineering; AbbVie;
   Alzheimer's Association; Alzheimer's Drug Discovery Foundation; Araclon
   Biotech; BioClinica, Inc.; Biogen; BristolMyers Squibb Company;
   CereSpir, Inc.; Cogstate; Eisai Inc.; Elan Pharmaceuticals, Inc.; Eli
   Lilly and Company; EuroImmun; F. Hoffmann-La Roche Ltd and its
   affiliated company Genentech, Inc.; Fujirebio; GE Healthcare; IXICO
   Ltd.; Janssen Alzheimer Immunotherapy Research & Development, LLC.;
   Johnson & Johnson Pharmaceutical Research & Development LLC.; NeuroRx
   Research; Neurotrack Technologies; Novartis Pharmaceuticals Corporation;
   Pfizer Inc.; Piramal Imaging; Servier; Takeda Pharmaceutical Company;
   Transition Therapeutics; Canadian Institutes of Health Research
FX This research was supported by the National Institute on Aging (NIA) of
   the National Institutes of Health (NIH) R01AG068882 (awarded to SMH) and
   R21AG056921 (awarded to SMH); and The Ohio State University Discovery
   Themes Chronic Brain Injury Initiative (awarded to SMH). Data collection
   and sharing for this project was funded by the Alzheimer's Disease
   Neuroimaging Initiative (ADNI) (National Institutes of Health Grant
   U01AG024904) andDODADNI (Department of Defense award number
   W81XWH-12-2-0012). ADNI is funded by the National Institute on Aging,
   the National Institute of Biomedical Imaging and Bioengineering, and
   through generous contributions from the following: AbbVie, Alzheimer's
   Association; Alzheimer's Drug Discovery Foundation; Araclon Biotech;
   BioClinica, Inc.; Biogen; BristolMyers Squibb Company; CereSpir, Inc.;
   Cogstate; Eisai Inc.; Elan Pharmaceuticals, Inc.; Eli Lilly and Company;
   EuroImmun; F. Hoffmann-La Roche Ltd and its affiliated company
   Genentech, Inc.; Fujirebio; GE Healthcare; IXICO Ltd.; Janssen Alzheimer
   Immunotherapy Research & Development, LLC.; Johnson & Johnson
   Pharmaceutical Research & Development LLC.; Lumosity; Lundbeck; Merck &
   Co., Inc.; Meso Scale Diagnostics, LLC.; NeuroRx Research; Neurotrack
   Technologies; Novartis Pharmaceuticals Corporation; Pfizer Inc.; Piramal
   Imaging; Servier; Takeda Pharmaceutical Company; and Transition
   Therapeutics. The Canadian Institutes of Health Research is providing
   funds to support ADNI clinical sites in Canada. Private sector
   contributions are facilitated by the Foundation for the National
   Institutes of Health (http://www.fnih.org).The grantee organization is
   the Northern California Institute for Research and Education, and the
   study is coordinated by the Alzheimer's Therapeutic Research Institute
   at the University of Southern California. ADNIdata are disseminated by
   the Laboratory for Neuro Imaging at the University of Southern
   California.
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NR 66
TC 2
Z9 2
U1 0
U2 4
PU IOS PRESS
PI AMSTERDAM
PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS
SN 1387-2877
EI 1875-8908
J9 J ALZHEIMERS DIS
JI J. Alzheimers Dis.
PY 2023
VL 93
IS 2
BP 633
EP 651
DI 10.3233/JAD-221084
PG 19
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA G5ON8
UT WOS:000989648900021
PM 37066909
OA Green Submitted, Green Accepted
DA 2025-06-11
ER

PT J
AU Mohamed, S
AF Mohamed, Suhaila
TI Functional foods against metabolic syndrome (obesity, diabetes,
   hypertension and dyslipidemia) and cardiovasular disease
SO TRENDS IN FOOD SCIENCE & TECHNOLOGY
LA English
DT Review
ID EGGPLANT SOLANUM-MELONGENA; ALLIUM-CEPA L.; OXIDATIVE STRESS; GREEN TEA;
   IN-VITRO; BODY-WEIGHT; INSULIN-RESISTANCE; PANCREATIC LIPASE;
   HEALTH-BENEFITS; ADIPOSE-TISSUE
AB Metabolic syndrome is a condition of at least three of the cardiovascular risk factors: obesity, excessive visceral fat storage, dyslipidemia, hypertension and hyperglycaemia or Type 2 diabetes. It is a state of insulin resistance, oxidative stress and chronic inflammation. Cardiovascular disease is the highest cause of death globally. Certain dietary components and over 800 plants help prevent or moderate metabolic syndrome by assisting the body homeostasis mechanisms. This review compiles the most current studies on foods that help fight metabolic syndrome and the scientific evidences to support their use. This includes functional fats, digestive enzymes inhibitors, various beverages, different fruits, specific vegetables, grains, legumes, herbs and spices that can reduce cardiovascular disease risk, through several cellular mechanisms.
C1 Univ Putra Malaysia, Inst BioSci, Serdang 43444, Selangor, Malaysia.
C3 Universiti Putra Malaysia
RP Mohamed, S (corresponding author), Univ Putra Malaysia, Inst BioSci, Serdang 43444, Selangor, Malaysia.
EM mohamed.suhaila@gmail.com
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NR 154
TC 152
Z9 168
U1 3
U2 178
PU ELSEVIER SCIENCE LONDON
PI LONDON
PA 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND
SN 0924-2244
J9 TRENDS FOOD SCI TECH
JI Trends Food Sci. Technol.
PD FEB
PY 2014
VL 35
IS 2
BP 114
EP 128
DI 10.1016/j.tifs.2013.11.001
PG 15
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA AB8RM
UT WOS:000332057700003
DA 2025-06-11
ER

PT J
AU Hosseini, A
   Hosseinzadeh, H
AF Hosseini, A.
   Hosseinzadeh, H.
TI A review on the effects of Allium sativum (Garlic) in metabolic
   syndrome
SO JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
LA English
DT Review
DE Garlic; Allium sativum; Metabolic syndrome; Cardiovascular disease;
   Hypertension; Diabetes; Dyslipidemia; Obesity
ID REDUCES BLOOD-PRESSURE; LIPID-METABOLISM; POWDER TABLETS; SERUM-LIPIDS;
   CARDIOVASCULAR RISK; OXIDATIVE STRESS; DIABETIC-NEPHROPATHY; EXTRACT
   CONSUMPTION; ANTIFUNGAL ACTIVITY; DIALLYL DISULFIDE
AB The metabolic syndrome is a common problem world-wide and includes abdominal obesity, hypertension, dyslipidemia, and hyperglycemia disorders. It leads to insulin resistance and the development of diabetes mellitus or cardiovascular disease. Allium sativum (garlic) has been documented to exhibit anti-diabetic, hypotensive, and hypolipidemic properties. This suggests a potential role of A. sativum in the management of metabolic syndrome; however, more studies should be conducted to evaluate its effectiveness. In this review, we discussed the most relevant articles to find out the role of A. sativum in different components of metabolic syndrome and cardiovascular disease risk factors. Because human reports are rare, further studies are required to establish the clinical value of A. sativum in metabolic syndrome.
C1 [Hosseini, A.] Mashhad Univ Med Sci, Pharmacol Res Ctr Med Plants, Sch Med, Mashhad, Iran.
   [Hosseinzadeh, H.] Mashhad Univ Med Sci, Sch Pharm, Dept Pharmacodynam & Toxicol, Pharmaceut Res Ctr, Mashhad, Iran.
C3 Mashhad University of Medical Sciences; Mashhad University of Medical
   Sciences
RP Hosseinzadeh, H (corresponding author), Mashhad Univ Med Sci, Sch Pharm, Dept Pharmacodynam & Toxicol, Pharmaceut Res Ctr, Mashhad, Iran.
EM hosseinzadehh@mums.ac.ir
RI Hosseini, Azar/O-4753-2018; Hosseinzadeh, Hossein/F-3013-2010
OI Hosseinzadeh, Hossein/0000-0002-3483-851X; naseri,
   shahrokh/0000-0001-8974-2120
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NR 130
TC 117
Z9 120
U1 1
U2 66
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0391-4097
EI 1720-8386
J9 J ENDOCRINOL INVEST
JI J. Endocrinol. Invest.
PD NOV
PY 2015
VL 38
IS 11
BP 1147
EP 1157
DI 10.1007/s40618-015-0313-8
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA CT3BU
UT WOS:000362681800001
PM 26036599
DA 2025-06-11
ER

PT J
AU Bajor, LA
   Lai, ZS
   Goodrich, DE
   Miller, CJ
   Penfold, RB
   Kim, HM
   Bauer, MS
   Kilbourne, AM
AF Bajor, Laura A.
   Lai, Zongshan
   Goodrich, David E.
   Miller, Christopher J.
   Penfold, Robert B.
   Kim, Hyungjin Myra
   Bauer, Mark S.
   Kilbourne, Amy M.
TI Posttraumatic stress disorder, depression, and health-related quality of
   life in patients with bipolar disorder: Review and new data from a
   multi-site community clinic sample
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Quality of life; Bipolar disorder; Posttraumatic stress disorders;
   Comorbidity
ID TREATMENT ENHANCEMENT PROGRAM; SELF-REPORTED DIAGNOSIS;
   COGNITIVE-BEHAVIORAL THERAPY; COMORBID ANXIETY DISORDERS; ALCOHOL-USE
   DISORDERS; PSYCHOSOCIAL INTERVENTIONS; SYMPTOMATIC STATUS; METABOLIC
   SYNDROME; RISK DRINKING; I DISORDER
AB Background: Evidence suggests that patients with bipolar disorder have an elevated risk for comorbid posttraumatic stress disorder (PTSD) compared to those without a bipolar diagnosis. Although bipolar disorder is associated with decreased health-related quality of life (HRQOL), it is unclear whether comorbid PTSD interacts to affect HRQOL.
   Method: Baseline data from a multi-site study of patients with bipolar disorder were analyzed. Patient surveys ascertained clinical and demographic information, including physical and mental HRQOL based on the SF-12, mood symptoms (PHQ-9, Internal State Scale), and self-reported co-occurring conditions including PTSD.
   Results: Overall (N=384), 44.9% of patients self-reported co-occurring PTSD. Patients with PTSD had lower physical and mental HRQOL scores compared to those without PTSD (mean (SD) for those with and without PTSD, respectively): Mental Component Scale score 30.51 (8.22) and 32.86 (8.35); Physical Component Scale score 35.56 (7.77) and 37.21 (7.20). After adjusting for demographic and clinical factors including mood symptoms, multiple linear regression analyses revealed that PTSD was no longer significantly associated with physical or mental HRQOL; however, depressive symptoms were independently associated with mental HRQOL (Beta -0.63, p < 0.01).
   Conclusion: Depressive symptoms may explain the association between PTSD and mental HRQOL. Clinicians working with these patients will want to emphasize treatment of depression as important towards improving HRQOL for this group. Published by Elsevier B.V.
C1 [Bajor, Laura A.; Miller, Christopher J.; Bauer, Mark S.] VA Boston Healthcare Syst, Ctr Org Leadership & Management Res, Boston, MA USA.
   [Lai, Zongshan; Goodrich, David E.; Kim, Hyungjin Myra; Kilbourne, Amy M.] VA Ann Arbor Ctr Clin Management Res, Ann Arbor, MI USA.
   [Bajor, Laura A.; Bauer, Mark S.] Harvard Univ, Sch Med, Dept Psychiat, Boston, MA 02115 USA.
   [Kilbourne, Amy M.] Univ Michigan, Sch Med, Dept Psychiat, Ann Arbor, MI USA.
   [Penfold, Robert B.] Grp Hlth Res Inst, Seattle, WA USA.
   [Penfold, Robert B.] Univ Washington, Sch Publ Hlth, Seattle, WA 98195 USA.
   [Kim, Hyungjin Myra] Univ Michigan, Ctr Stat Consultat & Res, Ann Arbor, MI 48109 USA.
C3 Harvard University; Harvard University Medical Affiliates; US Department
   of Veterans Affairs; Veterans Health Administration (VHA); VA Boston
   Healthcare System; Harvard University; Harvard Medical School;
   University of Michigan System; University of Michigan; University of
   Washington; University of Washington Seattle; University of Michigan
   System; University of Michigan
RP Bajor, LA (corresponding author), VA Boston Healthcare Syst, Ctr Org Leadership & Management Res, 150S Huntington Ave 152M, Boston, MA USA.
EM laura_bajor@hms.harvard.edu
RI Miller, Christopher/ABC-5892-2021
OI Goodrich, David/0000-0003-3232-2189
FU NIMH [R01 MH79994]; Department of Veterans Affairs Research Grant [IIR
   10-314]
FX This work was supported by NIMH (R01 MH79994 to AMK) and the Department
   of Veterans Affairs Research Grant (IIR 10-314 to MSB). The views
   expressed in this article are those of the authors and do not
   necessarily represent the views of the Department of Veterans Affairs.
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NR 82
TC 24
Z9 27
U1 0
U2 29
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD FEB 20
PY 2013
VL 145
IS 2
BP 232
EP 239
DI 10.1016/j.jad.2012.08.005
PG 8
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA 078IN
UT WOS:000314092100013
PM 23021820
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Belsare, PV
   Watve, MG
   Ghaskadbi, SS
   Bhat, DS
   Yajnik, CS
   Jog, M
AF Belsare, Prajakta V.
   Watve, Milind G.
   Ghaskadbi, Saroj S.
   Bhat, Dattatraya S.
   Yajnik, Chittaranjan S.
   Jog, Maithili
TI Metabolic syndrome: Aggression control mechanisms gone out of control
SO MEDICAL HYPOTHESES
LA English
DT Article
ID NITRIC-OXIDE SYNTHASE; INDUCED INSULIN-RESISTANCE;
   EPIDERMAL-GROWTH-FACTOR; LOW-GRADE INFLAMMATION; MALE-MICE LACKING;
   DIABETES-MELLITUS; OXIDATIVE STRESS; IN-VITRO; PANCREATIC-ISLETS;
   BETA-ENDORPHIN
AB An upcoming hypothesis about the evolutionary origins of metabolic syndrome is that of a 'soldier' to 'diplomat' transition in behaviour and the accompanying metabolic adaptations. Theoretical as well as empirical studies have shown that similar to the soldier and diplomat dichotomy, physically aggressive and non-aggressive strategists coexist in animal societies with negative frequency dependent selection. Although dominant individuals have a higher reproductive success obtained through means such as greater access to females, subordinate individuals have alternative means such as sneak-mating for gaining a substantial reproductive success. The alternative behavioural strategies are associated with different neurophysiologic and metabolic states. Subordinate individuals typically have low testosterone, high plasma cholesterol and glucocorticoids and elevated serotonin signalling whereas dominant ones are characterized by high testosterone, low brain serotonin and lower plasma cholesterol. Food and sex are the main natural causes of aggression. However, since aggression increases the risk of injury, aggression control is equally crucial. Therefore chronic satiety in the form of fat should induce aggression control. It is not surprising that the satiety hormone serotonin has a major role in aggression control. Further chronically elevated serotonin signalling in the hypothalamus induces peripheral insulin resistance. Meta-analysis shows that most of the anti-aggression signal molecules are pro-obesity and pro-insulin-resistance. Physical aggression is known to increase secretion of epidermal growth factor (EGF) in anticipation of injuries and EGF is important in pancreatic beta cell regeneration too. in anticipation of injuries aggression related hormones also facilitate angiogenesis and angiogenesis dysfunction is the root cause of a number of co-morbidities of insulin resistance syndrome. Reduced injury proneness typical of 'diplomat' life style would also reorient the immune system resulting into delayed wound healing on the one hand and increased systemic inflammation on the other. Diabetes is negatively associated with physically aggressive behaviour. We hypothesize that suppression of physical aggression is the major behavioural cue for the development of metabolic syndrome. Preliminary trials of behavioural intervention indicate that games and exercises involving physical aggression reduce systemic inflammation and improve glycemic control. (C) 2009 Elsevier Ltd. All rights reserved.
C1 [Watve, Milind G.] Indian Inst Sci Educ & Res, Pune 411021, Maharashtra, India.
   [Belsare, Prajakta V.; Ghaskadbi, Saroj S.] Univ Pune, Dept Zool, Pune, Maharashtra, India.
   [Watve, Milind G.] Anujeeva Biosci Pvt Ltd, Pune, Maharashtra, India.
   [Bhat, Dattatraya S.; Yajnik, Chittaranjan S.] KEM Hosp & Res Ctr, Diabetol Res Ctr, Pune, Maharashtra, India.
   [Jog, Maithili] Abasaheb Garware Coll, Dept Biotechnol, Pune, Maharashtra, India.
C3 Indian Institute of Science Education & Research (IISER) Pune;
   Savitribai Phule Pune University; Savitribai Phule Pune University;
   Abashaheb Garware College
RP Watve, MG (corresponding author), Indian Inst Sci Educ & Res, Sai Trinity Bldg, Pune 411021, Maharashtra, India.
EM milind@iiserpune.ac.in
FU CSIR; University of Pune; KanBiosys; LabIndia
FX CSIR supported PB during the study period, partial funding was obtained
   from the University of Pune, KanBiosys and LabIndia for the volunteer
   trials.
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NR 247
TC 15
Z9 19
U1 0
U2 29
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0306-9877
EI 1532-2777
J9 MED HYPOTHESES
JI Med. Hypotheses
PD MAR
PY 2010
VL 74
IS 3
BP 578
EP 589
DI 10.1016/j.mehy.2009.09.014
PG 12
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 569OV
UT WOS:000275608000035
PM 19800745
DA 2025-06-11
ER

PT J
AU Mackie, K
AF Mackie, K
TI Cannabinoid receptors as therapeutic targets
SO ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY
SE Annual Review of Pharmacology and Toxicology
LA English
DT Review; Book Chapter
DE analgesia; endocannabinoid; fatty acid aminohydrolase; metabolic
   syndrome; neuroinflammation; obesity
ID FATTY-ACID AMIDE; NITRIC-OXIDE PRODUCTION; LONG-TERM DEPRESSION; IN-VIVO
   EXPOSURE; CB1 RECEPTOR; ENDOGENOUS CANNABINOIDS; MOLECULAR
   CHARACTERIZATION; INVERSE AGONIST; MONOACYLGLYCEROL LIPASE;
   ENDOCANNABINOID SYSTEM
AB CB1 and CB2 cannabinoid receptors are the primary targets of endogenous cannabinoids (endocannabinoids). These G protein-coupled receptors play an important role in many processes, including metabolic regulation, craving, pain, anxiety, bone growth, and immune function. Cannabinoid receptors can be engaged directly by agonists or antagonists, or indirectly by manipulating endocannabinoid metabolism. In the past several years, it has become apparent from preclinical studies that therapies either directly or indirectly influencing cannabinoid receptors might be clinically useful. This review considers the components of the endocannabinoid system and discusses some of the most promising endocannabinoid-based therapies.
C1 Univ Washington, Dept Anesthesiol, Sch Med, Seattle, WA 98195 USA.
   Univ Washington, Dept Physiol & Biophys, Sch Med, Seattle, WA 98195 USA.
C3 University of Washington; University of Washington Seattle; University
   of Washington; University of Washington Seattle
RP Univ Washington, Dept Anesthesiol, Sch Med, Seattle, WA 98195 USA.
EM kmackie@u.washington.edu
RI Mackie, Kenneth/B-7358-2011; Mackie, Ken/E-3715-2013
OI Mackie, Ken/0000-0001-8501-6199
FU NIDA NIH HHS [DA 000286] Funding Source: Medline
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NR 152
TC 386
Z9 463
U1 1
U2 30
PU ANNUAL REVIEWS
PI PALO ALTO
PA 4139 EL CAMINO WAY, PO BOX 10139, PALO ALTO, CA 94303-0139 USA
SN 0362-1642
EI 1545-4304
J9 ANNU REV PHARMACOL
JI Annu. Rev. Pharmacol. Toxicol.
PY 2006
VL 46
BP 101
EP 122
DI 10.1146/annurev.pharmtox.46.120604.141254
PG 22
WC Pharmacology & Pharmacy; Toxicology
WE Book Citation Index – Science (BKCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Toxicology
GA 021KE
UT WOS:000235981300004
PM 16402900
DA 2025-06-11
ER

PT J
AU Yin, JH
   Li, SY
   Li, JL
   Gong, RP
   Jia, ZX
   Liu, JJ
   Jin, Z
   Yang, JG
   Liu, YX
AF Yin, Jiahui
   Li, Siyuan
   Li, Jinling
   Gong, Rongpeng
   Jia, Zhixia
   Liu, Junjun
   Jin, Zhi
   Yang, Jiguo
   Liu, Yuanxiang
TI Association of serum oleic acid level with depression in American
   adults: a cross-sectional study
SO BMC PSYCHIATRY
LA English
DT Article
DE Depression; Oleic acid; Fatty acid; Cross-sectional study
ID PATIENT HEALTH QUESTIONNAIRE-9; FATTY-ACIDS; METABOLIC SYNDROME; US
   ADULTS; SYMPTOMS; PHQ-9; PREVALENCE; DIAGNOSIS; SCORE
AB BackgroundAs the most abundant fatty acid in plasma, oleic acid has been found to be associated with multiple neurological diseases; however, results from studies of the relationship between oleic acid and depression are inconsistent.MethodsThis cross-sectional study analyzed 4,459 adults from the National Health and Nutrition Examination Survey 2011-2014. The following covariates were adjusted in multivariable logistic regression models: age, sex, race/ethnicity, education level, marital status, body mass index, physical activity, smoking status, alcohol status, metabolic syndrome, omega-3 polyunsaturated fatty acids, and total cholesterol.ResultsSerum oleic acid levels were positively associated with depression. After adjusting for all covariates, for every 1 mmol/L increase in oleic acid levels, the prevalence of depression increased by 40% (unadjusted OR: 1.35, 95%CI: 1.16-1.57; adjusted OR: 1.40, 95% CI: 1.03-1.90).ConclusionsOur study suggests that oleic acid may play a role in depression. Further research is needed to investigate the potential benefits of changing oleic acid levels for the treatment and prevention of depression.
C1 [Yin, Jiahui] Shandong Univ Tradit Chinese Med, Coll Tradit Chinese Med, Jinan, Peoples R China.
   [Li, Siyuan] Shanghai Jiao Tong Univ, Sch Med, Shanghai Mental Hlth Ctr, Dept Psychiat, Shanghai, Peoples R China.
   [Li, Jinling; Yang, Jiguo] Shandong Univ Tradit Chinese Med, Coll Acupuncture & Massage, Jinan, Peoples R China.
   [Gong, Rongpeng] Rhein Westfal TH Aachen, Aachen, Germany.
   [Jia, Zhixia] Shandong Univ Tradit Chinese Med, Clin Med Coll 1, Jinan, Peoples R China.
   [Liu, Junjun] Nanjing Meishan Hosp, Nanjing, Peoples R China.
   [Jin, Zhi] Fudan Univ, Shanghai Peoples Hosp 5, Dept Neurol, Shanghai, Peoples R China.
   [Liu, Yuanxiang] Shandong Univ Tradit Chinese Med, Affiliated Hosp, Dept Neurol, Jinan, Peoples R China.
C3 Shandong University of Traditional Chinese Medicine; Shanghai Jiao Tong
   University; Shandong University of Traditional Chinese Medicine; RWTH
   Aachen University; Shandong University of Traditional Chinese Medicine;
   Fudan University; Shandong University of Traditional Chinese Medicine
RP Yang, JG (corresponding author), Shandong Univ Tradit Chinese Med, Coll Acupuncture & Massage, Jinan, Peoples R China.; Liu, YX (corresponding author), Shandong Univ Tradit Chinese Med, Affiliated Hosp, Dept Neurol, Jinan, Peoples R China.
EM jiguoyang@126.com; lyxlwtg@126.com
RI liu, junjun/ABE-3338-2021; Li, SY/JPK-3839-2023; Rongpeng,
   Gong/CAH-4022-2022; LIU, XUANYOU/ABM-0984-2022; Jin, Zhi/E-1288-2013;
   Yin, Jiahui/ACP-2521-2022; li, jinling/HRD-0858-2023
OI Yin, Jiahui/0000-0002-4577-1605; , Rongpeng Gong/0000-0003-1117-0956
FU Not applicable.
FX Not applicable.
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NR 49
TC 7
Z9 7
U1 3
U2 12
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-244X
J9 BMC PSYCHIATRY
JI BMC Psychiatry
PD NOV 16
PY 2023
VL 23
IS 1
AR 845
DI 10.1186/s12888-023-05271-0
PG 9
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychiatry
GA Y6ET0
UT WOS:001106177700001
PM 37974120
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Chapman, MJ
   Orsoni, A
   Tan, R
   Mellett, NA
   Nguyen, A
   Robillard, P
   Giral, P
   Thérond, P
   Meikle, PJ
AF Chapman, M. John
   Orsoni, Alexina
   Tan, Ricardo
   Mellett, Natalie A.
   Nguyen, Anh
   Robillard, Paul
   Giral, Philippe
   Therond, Patrice
   Meikle, Peter J.
TI LDL subclass lipidomics in atherogenic dyslipidemia: effect of statin
   therapy on bioactive lipids and dense LDL[S]
SO JOURNAL OF LIPID RESEARCH
LA English
DT Article
DE metabolic syndrome; pitavastatin calcium; isopycnic density gradient
   ultracentrifugation; low density lipoprotein subclass heterogeneity;
   liquid chromatography electrospray ionization-tandem mass spectrometry;
   lipoprotein-associated phospholipase A2; lysophosphatidylcholine;
   ceramides; low density lipoprotein
ID CHOLESTERYL ESTER TRANSFER; PLATELET-ACTIVATING-FACTOR;
   CORONARY-ARTERY-DISEASE; LIPOPROTEIN PARTICLES; APOLIPOPROTEIN B-100;
   METABOLIC SYNDROME; DOSE PITAVASTATIN; OXIDATIVE STRESS; HUMAN-PLASMA;
   LYSOPHOSPHATIDYLCHOLINE
AB Atherogenic LDL particles are physicochemically and metabolically heterogeneous. Can bioactive lipid cargo differentiate LDL subclasses, and thus potential atherogenicity? What is the effect of statin treatment? Obese hypertriglyceridemic hypercholesterolemic males [n = 12; lipoprotein (a) <10 mg/dl] received pitavastatin calcium (4 mg/day) for 180 days in a single-phase unblinded study. The lipidomic profiles (23 lipid classes) of five LDL subclasses fractionated from baseline and post-statin plasmas were determined by LC-MS. At baseline and on statin treatment, very small dense LDL (LDL5) was preferentially enriched (up to 3-fold) in specific lysophospholipids {LPC, lysophosphatidylinositol (LPI), lysoalkylphosphatidylcholine [LPC(O)]; 9, 0.2, and 0.14 mol per mole of apoB, respectively; all P < 0.001 vs. LDL1-4}, suggesting elevated inflammatory potential per particle. In contrast, lysophosphatidylethanolamine was uniformly distributed among LDL subclasses. Statin treatment markedly reduced absolute plasma concentrations of all LDL subclasses (up to 33.5%), including LPC, LPI, and LPC(O) contents (up to -52%), consistent with reduction in cardiovascular risk. Despite such reductions, lipotoxic ceramide load per particle in LDL1-5 (1.5-3 mol per mole of apoB; 3-7 mmol per mole of PC) was either conserved or elevated. Bioactive lipids may constitute biomarkers for the cardiometabolic risk associated with specific LDL subclasses in atherogenic dyslipidemia at baseline, and with residual risk on statin therapy.
C1 [Chapman, M. John; Robillard, Paul] Sorbonne Univ, Pitie Salpetriere Univ Hosp, Endocrinol Metab Div, Paris, France.
   [Chapman, M. John; Robillard, Paul] Natl Inst Hlth & Med Res INSERM, Paris, France.
   [Chapman, M. John; Tan, Ricardo; Mellett, Natalie A.; Nguyen, Anh; Meikle, Peter J.] Baker Heart & Diabet Inst, Metabol Lab, Melbourne, Vic, Australia.
   [Orsoni, Alexina; Therond, Patrice] Bicetre Univ Hosp, HU Paris Saclay, AP HP, Serv Biochim, Le Kremlin Bicetre, France.
   [Giral, Philippe] Paris Saclay Univ, EA 7357, Chatenay Malabry, France.
   [Giral, Philippe] Pitie Salpetriere Univ Hosp, AP HP, INSERM, UMR1166,ICAN Inst CardioMetab & Nutr, Paris, France.
   [Giral, Philippe] Pitie Salpetriere Univ Hosp, AP HP, Cardiovasc Prevent Units, ICAN Inst CardioMetab & Nutr, Paris, France.
C3 Sorbonne Universite; Assistance Publique Hopitaux Paris (APHP); Hopital
   Universitaire Pitie-Salpetriere - APHP; Institut National de la Sante et
   de la Recherche Medicale (Inserm); Assistance Publique Hopitaux Paris
   (APHP); Hopital Universitaire Bicetre - APHP; Universite Paris Saclay;
   Sorbonne Universite; Assistance Publique Hopitaux Paris (APHP); Hopital
   Universitaire Pitie-Salpetriere - APHP; Institut National de la Sante et
   de la Recherche Medicale (Inserm); Sorbonne Universite; Assistance
   Publique Hopitaux Paris (APHP); Hopital Universitaire Pitie-Salpetriere
   - APHP
RP Chapman, MJ (corresponding author), Baker Heart & Diabet Inst, Metabol Lab, Melbourne, Vic, Australia.
EM john.chapman@upmc.fr
RI ORSONI, Alexina/C-6740-2009; Meikle, Peter/B-4023-2009; Anh,
   Nguyễn/HGU-8434-2022
OI Meikle, Peter/0000-0002-2593-4665
FU Kowa Research Europe; Association for Research on Lipoproteins and
   Atherogenesis (ARLA); Nouvelle Societe Francaise d'Atherosclerose (NSFA)
FX The authors gratefully acknowledge Mr. M. Suzuki for critical logistical
   support in clinical studies, Dr. P. Betting and colleagues at the
   Clinical Unit of SGS Aster, Paris, for patient recruitment and
   follow-up, and Dr. A. Carrie for apoE genotyping. The authors are
   indebted to Dr. N. Hounslow for critical discussion of the clinical
   protocol. A.O. is indebted to Kowa Research Europe, the Nouvelle Societe
   Francaise d'Atherosclerose (NSFA), and the Association for Research on
   Lipoproteins and Atherogenesis (ARLA) for support.
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NR 78
TC 45
Z9 45
U1 0
U2 5
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0022-2275
EI 1539-7262
J9 J LIPID RES
JI J. Lipid Res.
PD JUN
PY 2020
VL 61
IS 6
BP 911
EP 932
DI 10.1194/jlr.P119000543
PG 22
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA LU6II
UT WOS:000537856600010
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Sugiura, M
   Nakamura, M
   Ogawa, K
   Ikoma, Y
   Matsumoto, H
   Ando, F
   Shimokata, H
   Yano, M
AF Sugiura, Minoru
   Nakamura, Mieko
   Ogawa, Kazunori
   Ikoma, Yoshinori
   Matsumoto, Hikaru
   Ando, Fujiko
   Shimokata, Hiroshi
   Yano, Masamichi
TI Associations of serum carotenoid concentrations with the metabolic
   syndrome: interaction with smoking
SO BRITISH JOURNAL OF NUTRITION
LA English
DT Article
DE Carotenoids; Metabolic syndrome; Smoking; Cross-sectional studies
ID CORONARY-HEART-DISEASE; BODY-MASS INDEX; 3RD NATIONAL-HEALTH; WAIST
   CIRCUMFERENCE; INSULIN-RESISTANCE; DIABETES-MELLITUS; OXIDATIVE STRESS;
   BETA-CAROTENE; RISK-FACTORS; CARDIOVASCULAR-DISEASE
AB Recent epidemiological Studies show the associations of serum antioxidant status with the metabolic syndrome. Oxidative stress may play an important role in the pathogenesis of diabetes and CVD. Actually, smoking is a potent oxidative stressor in man, but little is known about the interaction of serum carotenoids and the metabolic syndrome with smoking status. In this study, the associations of the serum carotenoids with the metabolic syndrome stratified by smoking habit were evaluated cross-sectionally. A total of 1073 subjects (357 male and 716 female) who had received health examinations in the town of Mikkabi, Shizuoka Prefecture, Japan, participated in the Study. Among total subjects, the OR for the metabolic syndrome in the highest tertile of serum beta-carotene was 0.41 (95% CI 0.18, 0.92) after adjusting confounders. In current smokers, significantly lower OR were observed in the middle (OR 0.10; 95% CI 0.01, 0.72) and highest (OR 0.06; 95% CI 0.01, 0.73) tertiles of serum beta-carotene. Furthermore, lower OR were observed in accordance with tertiles of serum alpha-carotene and beta-cryptoxanthin in current smokers (P for trend 0.042 and 0.036, respectively). In contrast, in non-smokers, a significantly lower OR was observed in the highest tertile of serum beta-carotene (OR 0.30; 95% CI 0-10, 0.89) after multiple adjustment. Inverse associations of serum carotenoids with the metabolic syndrome were more evident among Current smokers than non-smokers. These results support that antioxidant carotenoids may have a protective effect against development of the metabolic syndrome, especially in current smokers who are exposed to a potent oxidative stress.
C1 [Sugiura, Minoru; Ogawa, Kazunori; Ikoma, Yoshinori; Matsumoto, Hikaru; Yano, Masamichi] Natl Inst Fruit Tree Sci, Res Team Hlth Benefit Fruit, Shizuoka 4240292, Japan.
   [Nakamura, Mieko; Ando, Fujiko; Shimokata, Hiroshi] Natl Inst Longev Sci, Dept Epidemiol, Aichi 4748522, Japan.
C3 National Agriculture & Food Research Organization - Japan
RP Sugiura, M (corresponding author), Natl Inst Fruit Tree Sci, Res Team Hlth Benefit Fruit, 485-6 Okitsunaka Cho, Shizuoka 4240292, Japan.
EM msugiura@affrc.go.jp
RI Nakamura, Mieko/AFS-0483-2022
OI Matsumoto, Hikaru/0000-0002-6486-9237
FU Ministry of Agriculture, Forestry and Fisheries (MAFF); Council for the
   Advancement of Fruit Tree Science.
FX This work was supported by a grant from the Ministry of Agriculture,
   Forestry and Fisheries (MAFF) for a food research project titled
   'Integrated Research on Safety and Physiological Function of Food' and a
   grant from the Council for the Advancement of Fruit Tree Science. We are
   grateful to the participants in our survey and to the staff of the
   health examination programme for residents of the town of Mikkabi,
   Shizuoka, Japan. We are also grateful to the staff of the Seirei
   Preventive Health Care Center (Shizuoka, Japan). M. S. was responsible
   for study design. data collection and data management, and carried out
   the data analysis and wrote the manuscript. M. N. was responsible for
   study design, data collection and data management, and assisted in
   manuscript preparation. K. O., Y. I., H. M.. F. A., H. S. and M. Y. were
   involved in the data collection and assisted in manuscript preparation.
   All the authors provided suggestions during the preparation of the
   manuscript and approved the final version submitted for publication.
   None of the authors had any personal or financial conflict of interest.
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NR 58
TC 59
Z9 65
U1 0
U2 6
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1145
EI 1475-2662
J9 BRIT J NUTR
JI Br. J. Nutr.
PD DEC
PY 2008
VL 100
IS 6
BP 1297
EP 1306
DI 10.1017/S0007114508978302
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 386RP
UT WOS:000261900600021
PM 18445303
OA Bronze
DA 2025-06-11
ER

PT J
AU Hong, XC
   Ma, YB
   Yang, WH
   Li, YK
   Tang, XF
   Wang, ZX
AF Hong, Xincai
   Ma, Yongbin
   Yang, Weihong
   Li, Yikun
   Tang, Xiufang
   Wang, Zhaoxia
TI Vitamin D and Dapagliflozin Alleviate Renal Injury and Insulin
   Resistance in a Diet-Induced Metabolic Syndrome Rat Model
SO JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
LA English
DT Article
DE dapagliflozin; insulin resistance; metabolic syndrome; renal injury;
   vitamin D
ID KIDNEY-DISEASE; GLUCOSE; INFLAMMATION; MECHANISMS; INHIBITORS
AB Metabolic syndrome, primarily driven by high-fat/high-sugar (HF/HS) diets, is closely linked to insulin resistance and renal injury, leading to serious complications such as type 2 diabetes mellitus and diabetic nephropathy. This study explored the combined effects of Vitamin D (VD) and dapagliflozin (Dap) on metabolic and renal complications in an HF/HS diet-induced rat model of metabolic syndrome. The combination therapy significantly improved insulin sensitivity, reduced fasting blood glucose levels, and alleviated renal injury markers such as blood urea nitrogen and creatinine. It also attenuated inflammation, lipid accumulation, and endoplasmic reticulum stress in renal tissues, as evidenced by reduced levels of inflammatory cytokines and key stress markers (GRP78 and CHOP). Importantly, the study highlights the novel synergistic potential of VD and Dap in addressing these complications through complementary mechanisms. These findings suggest that this combination therapy offers promising clinical potential for managing metabolic syndrome and its progression to severe complications.
C1 [Hong, Xincai; Yang, Weihong; Li, Yikun; Tang, Xiufang; Wang, Zhaoxia] Fengcheng Hosp Fengxian Dist, Dept Endocrinol & Metab, Shanghai, Peoples R China.
   [Ma, Yongbin] Jiangsu Univ, Jintan Hosp, Dept Cent Lab, Jintan, Peoples R China.
C3 Jiangsu University
RP Wang, ZX (corresponding author), Fengcheng Hosp Fengxian Dist, Dept Endocrinol & Metab, Shanghai, Peoples R China.
EM WangZhaoXia_1978@163.com
RI Ma, Yongbin/ITR-9256-2023
FU The authors received no specific funding for this work.
FX The authors have nothing to report.
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NR 42
TC 0
Z9 0
U1 1
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1095-6670
EI 1099-0461
J9 J BIOCHEM MOL TOXIC
JI J. Biochem. Mol. Toxicol.
PD MAR
PY 2025
VL 39
IS 3
AR e70185
DI 10.1002/jbt.70185
PG 11
WC Biochemistry & Molecular Biology; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Toxicology
GA Z5B0B
UT WOS:001439046300001
PM 40052404
DA 2025-06-11
ER

PT J
AU Lanza, GA
   Sestito, A
   Sgueglia, GA
   Infusino, F
   Papacci, F
   Visocchi, M
   Ierardi, C
   Meglio, M
   Bellocci, F
   Crea, F
AF Lanza, GA
   Sestito, A
   Sgueglia, GA
   Infusino, F
   Papacci, F
   Visocchi, M
   Ierardi, C
   Meglio, M
   Bellocci, F
   Crea, F
TI Effect of spinal cord stimulation on spontaneous and stress-induced
   angina and 'ischemia-like' ST-segment depression in patients with
   cardiac syndrome X
SO EUROPEAN HEART JOURNAL
LA English
DT Article
DE cardiac syndrome X; refractory angina; spinal cord stimulation; Hotter
   monitoring; dobutamine stress test
ID POSITRON-EMISSION-TOMOGRAPHY; MYOCARDIAL BLOOD-FLOW; CHEST-PAIN;
   PECTORIS; SENSITIVITY; PERFUSION
AB Aims A significant number of patients with cardiac syndrome X (CSX) present frequent episodes of severe chest pain, refractory to maximal multi-drug therapy. A few, small, uncontrolled data suggested that spinal cord stimulation (SCS) may have favourable clinical benefits in these patients.
   Methods and results We studied 10 CSX patients who were being treated by SCS for refractory angina pectoris for 17 16 months (median 8). Patients were randomized to either continue or withdraw SCS for a period of 3 weeks and were then crossed over to the other condition for a further 3-week period. During each 3-week period patients kept a detailed diary of angina episodes occurring in the last 2 weeks of each phase. Furthermore, at the end of each 3-week period, angina status was also assessed by Seattle Angina Questionnaire (SAQ), a 0-100 visual analogue scale (VAS), and patients underwent 24-h Hotter monitoring (HM) and echocardiographic dobutamine stress test (DST). Compared with the withdrawal phase, SCS reduced the number (P = 0.01), duration (P = 0.022), and severity (P = 0.011) of angina episodes, and nitrate consumption (P = 0.042). SAQ scores (P <= 0.013 for all) and VAS (P < 0.001) were also improved, the number of episodes of ST-segment depression on HM was decreased (P = 0.014), and time to angina (P = 0.045) and to 1 mm ST-segment depression (P = 0.04) during DST were both prolonged by SCS.
   Conclusions Our data point out that SCS may be an effective form of treatment in patients with CSX suffering from frequent angina episodes significantly impairing quality of life (QOL) and refractory to maximally tolerated drug therapy.
C1 Univ Cattolica Sacro Cuore, Ist Cardiol, I-00168 Rome, Italy.
   Univ Cattolica Sacro Cuore, Ist Neurochirurg, Rome, Italy.
C3 Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli;
   Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli
RP Univ Cattolica Sacro Cuore, Ist Cardiol, L A Gemelli,8, I-00168 Rome, Italy.
EM g.a.lanza@inwind.it
RI Lanza, Gaetano/AAC-2660-2019; visocchi, massimiliano/HSC-2527-2023;
   Sgueglia, Gregory/A-9701-2019; Infusino, Fabio/JEF-6750-2023
OI Sgueglia, Gregory/0000-0001-9680-7412; Infusino,
   Fabio/0000-0001-9287-5936
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NR 30
TC 52
Z9 54
U1 0
U2 3
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0195-668X
EI 1522-9645
J9 EUR HEART J
JI Eur. Heart J.
PD MAY
PY 2005
VL 26
IS 10
BP 983
EP 989
DI 10.1093/eurheartj/ehi089
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 929CY
UT WOS:000229320900010
PM 15642701
OA Bronze
DA 2025-06-11
ER

PT J
AU Lehaci, G
   Georgescu, C
   Dumitrescu, AM
   Gotca, I
   Ghiuru, R
   Stefanescu, C
AF Lehaci, Gica
   Georgescu, Costinela
   Dumitrescu, Ana-Maria
   Gotca, Ioan
   Ghiuru, Rodica
   Stefanescu, Cristinel
TI Psychological Coping and Social Aspects in the Case of the Elderly with
   Metabolic Syndrome
SO REVISTA DE CERCETARE SI INTERVENTIE SOCIALA
LA English
DT Article
DE metabolic syndrome; psychological coping; self-management; health;
   depression
ID DEPRESSION
AB The metabolic syndrome (MetS) represents a disease with a complex pathogenesis being associated with a constellation of metabolic and cardiovascular disorders, and not only, resulting from the co-occurrence of obesity, dyslipidemia, insulin resistance and type 2 diabetes mellitus, according to the American Education Guide "National Cholesterol Education Program Adult Treatment Panel III". We present the case of a 67-year-old patient, female, pensioner with metabolic syndrome diagnosed by the co-occurrence of stage I hypertension, grade I obesity, diabetes mellitus and dyslipidemia with hypercholesterolemia. People with MetS have a poorer quality of life, with references towards physical and social functions, regarding both general and mental states of health. With the help of a trained psychologist we interpreted the obtained results of the Freiburg Personality Inventory (FPI) and a Psychological Coping Questionnaire-Personal Needs Evaluation Questionnaire (V33A-GoldInc) and had a perspective upon patient's views regarding her personal illness and the involvement of spirituality, socioeconomic status and ethics in the management of the metabolic syndrome as a complex pathology, and particularly of the cardiovascular component of the disease. Regarding the presented case, it is indicated that the social worker, within the inter multidisciplinary relationship social worker-psychologist-doctor, interferes more with elderly on informing them about different sort of abuses against them, the risks of exposing their personal lives excessively, the matter of trust both within society and medical systems through community projects and information campaigns.
C1 [Lehaci, Gica] Univ Med & Pharm Grigore T Popa, Fac Med, Dept Psychiat, Iasi, Romania.
   [Georgescu, Costinela] Dunarea de Jos Univ Galati, Fac Med, Iasi, Romania.
   [Dumitrescu, Ana-Maria] Univ Med & Pharm Grigore T Popa, Fac Med, Iasi, Romania.
   [Gotca, Ioan] Ctr Mental Hlth Dr L Ghelerter, Iasi, Romania.
   [Ghiuru, Rodica] Romanian Railrd Co, Univ Clin Hosp, Iasi, Romania.
   [Stefanescu, Cristinel] Socola Clin Psychiat Hosp, Iasi, Romania.
C3 Grigore T Popa University of Medicine & Pharmacy; Dunarea De Jos
   University Galati; Grigore T Popa University of Medicine & Pharmacy
RP Georgescu, C (corresponding author), Dunarea de Jos Univ Galati, Fac Med, Iasi, Romania.
EM gica_lehaci@yahoo.com; costinelag@gmail.com;
   anna.dumitrescu91@gmail.com; igotca@yahoo.com; rodicaghiuru@yahoo.com;
   cristinel.stefanescu@gmail.com
RI Stefanescu, Cristinel/KLZ-7327-2024; Dumitrescu, Ana-Maria/HHC-9240-2022
OI Stefanescu, Cristinel/0000-0001-5254-6855
CR Albu A., 2001, ASISTENTA FAMILIE PE
   Alexa I. D., 2011, ACTUALITATI GERIATRI
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NR 24
TC 2
Z9 2
U1 0
U2 9
PU EXPERT PROJECTS PUBLISHING
PI IASI
PA IASI, STR VOINESTI 63, IASI, 700615, ROMANIA
SN 1583-3410
EI 1584-5397
J9 REV CERCET INTERV SO
JI Rev. Cercet. Interv. Soc.
PD MAR
PY 2016
VL 52
BP 273
EP 282
PG 10
WC Social Sciences, Interdisciplinary
WE Social Science Citation Index (SSCI)
SC Social Sciences - Other Topics
GA DI3TX
UT WOS:000373422500018
DA 2025-06-11
ER

PT J
AU Valtonen, M
   Laaksonen, DE
   Tolmunen, T
   Nyyssönen, K
   Viinamäki, H
   Kauhanen, J
   Niskanen, L
AF Valtonen, Maarit
   Laaksonen, David E.
   Tolmunen, Tommi
   Nyyssonen, Kristiina
   Viinamaki, Heimo
   Kauhanen, Jussi
   Niskanen, Leo
TI Hopelessness - novel facet of the metabolic syndrome in men
SO SCANDINAVIAN JOURNAL OF PUBLIC HEALTH
LA English
DT Article
DE Cohort study; depression; hopelessness; men; metabolic syndrome
ID ISCHEMIC-HEART-DISEASE; C-REACTIVE PROTEIN; MIDDLE-AGED MEN; DEPRESSIVE
   SYMPTOMS; DIABETES-MELLITUS; LIFE EVENTS; MORTALITY; RISK; POPULATION;
   HEALTH
AB Aims: Recent studies have shown that lack of hope is linked to cardiovascular morbidity and mortality. Little is known, however, about the relationship of hopelessness and the metabolic syndrome. The aim of this study is to examine the association of hopelessness and the metabolic syndrome. Methods: This cross-sectional study examines the relationship between hopelessness and the metabolic syndrome as defined by the National Cholesterol Education Program in a population-based cohort of 1743 non-diabetic men aged 42, 48, 54 and 60 years old at baseline ( 1984-89). Hopelessness was measured by one's expectations about the future and reaching goals. Results: In simple age-adjusted univariate analyses the prevalence of the metabolic syndrome, many of its components and other cardiovascular risk factors were more common in men with higher levels of hopelessness. In a logistic regression model adjusted for age, smoking, alcohol consumption, cardiovascular disease, adult socioeconomic status and physical activity, men in the highest third were 2.1 ( 95% CI 1.3-3.2) times more likely to have the metabolic syndrome than those in the lowest third. After further adjusting for body mass index and elevated depressive symptoms the respective figures were 1.9 ( 95% CI 1.2-3.1) and 2.1 ( 95% CI 1.4-3.4). Conclusions: Hopelessness was strongly associated with the metabolic syndrome in these middle-aged men, independent of other depressive symptoms and traditional cardiovascular risk factors. These findings suggest that hopelessness is very closely related to the metabolic syndrome. Therefore lifestyle management of the metabolic syndrome should also take into account patients' expectations more thoroughly than hitherto acknowledged.
C1 [Valtonen, Maarit] Cent Finland Cent Hosp, Dept Med, Jyvaskyla 40620, Finland.
   [Valtonen, Maarit; Laaksonen, David E.; Niskanen, Leo] Kuopio Univ Hosp, Dept Med, SF-70210 Kuopio, Finland.
   [Laaksonen, David E.] Univ Kuopio, Dept Physiol, Inst Biomed, FIN-70211 Kuopio, Finland.
   [Tolmunen, Tommi; Viinamaki, Heimo] Kuopio Univ Hosp, Dept Psychiat, Kuopio, Finland.
   [Nyyssonen, Kristiina; Kauhanen, Jussi] Univ Kuopio, Publ Hlth Res Inst, FIN-70211 Kuopio, Finland.
   [Kauhanen, Jussi] Univ Kuopio, Dept Publ Hlth & Gen Practice, FIN-70211 Kuopio, Finland.
C3 Central Finland Central Hospital; University of Eastern Finland;
   University of Eastern Finland Hospital; Kuopio University Hospital;
   University of Eastern Finland; University of Eastern Finland; University
   of Eastern Finland Hospital; Kuopio University Hospital; University of
   Eastern Finland; University of Eastern Finland
RP Valtonen, M (corresponding author), Cent Finland Cent Hosp, Dept Med, Keskussairaalantie 19, Jyvaskyla 40620, Finland.
EM maarit.valtonen@ksshp.fi
RI Kauhanen, Jussi/ABC-4064-2021
FU Academy of Finland [41471, 1041086, 2041022]; Ministry of Education of
   Finland [167/722/96, 157/722/97, 156/722/98]; National Heart, Lung and
   Blood Institute of the USA [HL44199]; Onni and Hilja Tuovinen Foundation
FX We thank the staff of the Research Institute of Public Health,
   University of Kuopio, and Kuopio Research Institute of Exercise Medicine
   for data collection in the KIHD study. The KIHD study was supported by
   grants from the Academy of Finland ( grants 41471, 1041086 and 2041022),
   the Ministry of Education of Finland ( grants 167/722/96, 157/722/97,
   156/722/98), and the National Heart, Lung and Blood Institute of the USA
   ( grant HL44199). M. V. is supported by grant from Onni and Hilja
   Tuovinen Foundation.
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NR 38
TC 17
Z9 17
U1 0
U2 4
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1403-4948
EI 1651-1905
J9 SCAND J PUBLIC HEALT
JI Scand. J. Public Health
PD NOV
PY 2008
VL 36
IS 8
BP 795
EP 802
DI 10.1177/1403494808094918
PG 8
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA 385PX
UT WOS:000261827200003
PM 19004897
DA 2025-06-11
ER

PT J
AU Garg, R
   Kumariya, S
   Katekar, R
   Verma, S
   Goand, UK
   Gayen, JR
AF Garg, Richa
   Kumariya, Sanjana
   Katekar, Roshan
   Verma, Saurabh
   Goand, Umesh K.
   Gayen, Jiaur R.
TI JNK signaling pathway in metabolic disorders: An emerging therapeutic
   target
SO EUROPEAN JOURNAL OF PHARMACOLOGY
LA English
DT Review
DE Metabolic syndrome; Insulin resistance; Stress kinases; c-JunN-terminal
   kinase; Inflammation; Obesity
ID N-TERMINAL-KINASE; DIET-INDUCED OBESITY; INDUCED INSULIN-RESISTANCE;
   ACTIVATED PROTEIN-KINASE; JUN NH2-TERMINAL KINASE; C-JUN; OXIDATIVE
   STRESS; SKELETAL-MUSCLE; INDUCED INFLAMMATION; CRYSTAL-STRUCTURE
AB Metabolic Syndrome is a multifactorial disease associated with increased risk of cardiovascular disorders, type 2 diabetes mellitus, fatty liver disease, etc. Various stress stimuli such as reactive oxygen species, endoplasmic reticulum stress, mitochondrial dysfunction, increased cytokines, or free fatty acids are known to aggravate progressive development of hyperglycemia and hyperlipidemia. Although the exact mechanism contributing to altered metabolism is unclear. Evidence suggests stress kinase role to be a crucial one in metabolic syndrome. Stress kinase, c-jun N-terminal kinase activation (JNK) is involved in various metabolic manifestations including obesity, insulin resistance, fatty liver disease as well as cardiometabolic disorders. It emerged as a foremost mediator in regulating metabolism in the liver, skeletal muscle, adipose tissue as well as pancreatic beta cells. It has three isoforms each having a unique and tissue-specific role in altered metabolism. Current findings based on genetic manipulation or chemical inhibition studies identified JNK isoforms to play a central role in the regulation of whole-body metabolism, suggesting it to be a novel therapeutic target. Hence, it is imperative to elucidate its role in metabolic syndrome onset and progression. The purpose of this review is to elucidate in vitro and in vivo implications of JNK signaling along with the therapeutic strategy to inhibit specific isoform. Since metabolic syndrome is an array of diseases and complex pathway, carefully examining each tissue will be important for specific treatment strategies.
C1 [Garg, Richa; Kumariya, Sanjana; Katekar, Roshan; Verma, Saurabh; Goand, Umesh K.; Gayen, Jiaur R.] CSIR, Cent Drug Res Inst, Pharmaceut & Pharmacokinet, Lucknow 226031, Uttar Pradesh, India.
   [Gayen, Jiaur R.] CSIR, Cent Drug Res Inst, Pharmacol Div, Lucknow 226031, Uttar Pradesh, India.
   [Garg, Richa; Katekar, Roshan; Verma, Saurabh; Goand, Umesh K.; Gayen, Jiaur R.] Acad Sci & Innovat Res AcSIR, Ghaziabad 201002, India.
C3 Council of Scientific & Industrial Research (CSIR) - India; CSIR -
   Central Drug Research Institute (CDRI); Council of Scientific &
   Industrial Research (CSIR) - India; CSIR - Central Drug Research
   Institute (CDRI); Academy of Scientific & Innovative Research (AcSIR)
RP Gayen, JR (corresponding author), CSIR, Cent Drug Res Inst, Pharmaceut & Pharmacokinet Div, Sect 10,Sitapur Rd, Lucknow 226031, Uttar Pradesh, India.
EM jr.gayen@edri.res.in
RI VERMA, SAURABH/HTO-8206-2023; KATEKAR, ROSHAN/U-5379-2019; Kumariya,
   Sanjana/JKI-2845-2023
OI Verma, Dr. Saurabh/0000-0001-8790-4704; Katekar,
   Roshan/0000-0003-1374-0828; Gayen, Jiaur/0000-0001-7703-9307
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NR 167
TC 31
Z9 35
U1 1
U2 23
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0014-2999
EI 1879-0712
J9 EUR J PHARMACOL
JI Eur. J. Pharmacol.
PD JUN 15
PY 2021
VL 901
AR 174079
DI 10.1016/j.ejphar.2021.174079
EA APR 2021
PG 13
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA SD3BV
UT WOS:000651249600001
PM 33812885
DA 2025-06-11
ER

PT J
AU Yu, R
   Woo, J
   Chan, AS
   Sze, SL
AF Yu, Ruby
   Woo, Jean
   Chan, Agnes S.
   Sze, Sophia L.
TI A Chinese Chan-based mind-body intervention improves
   psychological well-being and physical health of community-dwelling
   elderly: a pilot study
SO CLINICAL INTERVENTIONS IN AGING
LA English
DT Article
DE mind-body intervention; Chan practice; psychological stress; physical
   fitness; self-rated health; elderly
ID SELF-RATED HEALTH; SLEEP QUALITY INDEX; RANDOMIZED CONTROLLED-TRIAL;
   STRESS REDUCTION; OLDER-ADULTS; TAI CHI; CLINICAL-SIGNIFICANCE; PRIMARY
   INSOMNIA; BLOOD-PRESSURE; HYPERTENSION
AB Background: The aim of this study was to explore the potential benefits of the Dejian mind-body intervention (DMBI) for psychological and physical health in older Chinese adults.
   Methods: After confirmation of eligibility, the subjects were invited to receive DMBI once a week for 12 weeks. The intervention involved components of learning self-awareness and self-control, practicing mind-body exercises, and adopting a special vegetarian diet. Intervention-related changes were measured using the Perceived Stress Scale, Geriatric Depression Scale, Pittsburgh Sleep Quality Index, Chinese Constipation Questionnaire, and self-report ratings of health. Indicators of metabolic syndrome and walking speed were also measured.
   Results: Of the 44 subjects recruited, 42 (54.8% men) completed the study, giving an adherence rate of 95%. There was a significant reduction in perceived stress (P<0.05). A significant improvement was also found in systolic blood pressure among those who had abnormally high blood pressure at baseline (P<0.05). Physical fitness as reflected by walking speed was also significantly increased after the intervention (P<0.05). Sleep disturbances were reduced (P<0.01). Self-rated health was significantly enhanced, with the percentage rating very good health increasing from 14.3% at baseline to 42.8% after the intervention (P<0.001). No intervention effect was found for waist circumference, lipids and fasting blood glucose levels, Pittsburgh Sleep Quality Index global score, and constipation measures.
   Conclusion: The DMBI was feasible and acceptable, and subjects showed some improvements in psychological and physical health. A larger controlled trial is needed to confirm these promising preliminary results.
C1 [Yu, Ruby; Woo, Jean] Chinese Univ Hong Kong, Dept Med & Therapeut, Shatin, Hong Kong, Peoples R China.
   [Chan, Agnes S.; Sze, Sophia L.] Chinese Univ Hong Kong, Dept Psychol, Shatin, Hong Kong, Peoples R China.
   [Chan, Agnes S.; Sze, Sophia L.] Chinese Univ Hong Kong, Chanwuyi Res Ctr Neuropsychol Well Being, Shatin, Hong Kong, Peoples R China.
   [Chan, Agnes S.] Henan Songshan Res Inst Chanwuyi, Chanwuyi, Henan, Peoples R China.
C3 Chinese University of Hong Kong; Chinese University of Hong Kong;
   Chinese University of Hong Kong
RP Yu, R (corresponding author), Chinese Univ Hong Kong, Prince Wales Hosp, Dept Med & Therapeut, 10-F Clin Sci Bldg, Shatin, Hong Kong, Peoples R China.
EM rubyyu@cuhk.edu.hk
RI Yu, Ruby/N-5006-2015; Woo, Jean/K-2625-2014
OI Woo, Jean/0000-0001-7593-3081; Chan, Agnes/0000-0002-3321-182X
FU Health and Health Services Research Fund [10110931]
FX This work was supported by the Health and Health Services Research Fund
   (grant number 10110931) established by the Food and Health Bureau of the
   Hong Kong SAR. The authors would like to specially thank Venerbale
   Master Dejian of the Songshan monastery for his teaching and support.
   They are also grateful to Ms Winnie Yeung, Mr Moses Wong, Ms Fannie
   Yeung, Ms Maggie Ng, Ms Karoline Chiu, Ms Hannah Li and Ms Carman Chu
   for their effort in subject recruitment, data
   collection/management/analysis, and/or literature review. Further
   appreciation is extended to all participants and to the community health
   and social centers (The Centre for Nutritional Studies, Jockey Club
   Centre for Osteoporosis Care and Control, Sheen Hok Charitable
   Foundation Kwan Shon Hing Yu Chui Neighbourhood Elderly Centre, Jockey
   Club CADENZA Hub, Ho Hong Neighbourhood Centre for Senior Citizens, and
   Heng On Social Centre for the Elderly) for their assistance in the
   recruitment process.
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NR 60
TC 17
Z9 19
U1 4
U2 44
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
EI 1178-1998
J9 CLIN INTERV AGING
JI Clin. Interv. Aging
PY 2014
VL 9
BP 727
EP 736
DI 10.2147/CIA.S59985
PG 10
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA AF7SS
UT WOS:000334915600003
PM 24790425
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Llaneza, P
   González, C
   Fernandez-Iñarrea, J
   Alonso, A
   Arnott, I
   Ferrer-Barriendos, J
AF Llaneza, Placido
   Gonzalez, Celestino
   Fernandez-Inarrea, Jose
   Alonso, Ana
   Arnott, Ignacio
   Ferrer-Barriendos, Javier
TI Insulin resistence and health-related quality of life in postmenopausal
   women
SO FERTILITY AND STERILITY
LA English
DT Article
ID METABOLIC-SYNDROME; RISK-FACTORS; ASSOCIATION; DEPRESSION; RESISTANCE;
   MENOPAUSE; SYMPTOMS
AB Health-related quality of life (HR-QOL) was similar between the menopausal women with and without Insulin Resistance (IR). However, when IR women with Metabolic Syndrome were considered, a higher level of problems on the HR-QOL global score was found and the difference was mainly due to Health and Sexuality domains. (Fertil Steril (R) 2009;91:1370-3. (C)2009 by American Society for Reproductive Medicine.)
C1 [Llaneza, Placido; Arnott, Ignacio; Ferrer-Barriendos, Javier] Univ Oviedo, Cent Univ Hosp Asturias, Dept Gynaecol, E-33006 Oviedo, Spain.
   [Gonzalez, Celestino; Alonso, Ana] Univ Oviedo, Cent Univ Hosp Asturias, Physiol Area, E-33006 Oviedo, Spain.
   [Fernandez-Inarrea, Jose] Cabuenes Hosp, Dept Gynaecol, Cabuenes, Spain.
C3 University of Oviedo; Central University Hospital Asturias; University
   of Oviedo; Central University Hospital Asturias; Hospital Universitario
   de Cabuenes
RP Llaneza, P (corresponding author), Univ Oviedo, Cent Univ Hosp Asturias, Dept Gynaecol, C Celestino Villamil S-N, E-33006 Oviedo, Spain.
EM pllanezac@yahoo.es
RI Llaneza, Placido/AAJ-8974-2020; Gonzalez-Gonzalez, Celestino/A-2323-2008
OI Llaneza Coto, Placido/0000-0002-6735-4618; Alonso Garcia,
   Ana/0000-0003-4679-1744; Gonzalez-Gonzalez,
   Celestino/0000-0001-7309-9003
FU Health Investigation Grant funded by the Spanish Government [PI-O51616]
FX Supported by a Health Investigation Grant funded by the Spanish
   Government (PI-O51616).
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NR 18
TC 10
Z9 11
U1 0
U2 6
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0015-0282
EI 1556-5653
J9 FERTIL STERIL
JI Fertil. Steril.
PD APR
PY 2009
VL 91
IS 4
SU S
BP 1370
EP 1373
DI 10.1016/j.fertnstert.2008.04.031
PG 4
WC Obstetrics & Gynecology; Reproductive Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology; Reproductive Biology
GA 432KT
UT WOS:000265132600023
PM 18710709
OA Bronze
DA 2025-06-11
ER

PT J
AU Kunitomo, M
   Yamaguchi, Y
   Kagota, S
   Otsubo, K
AF Kunitomo, Masaru
   Yamaguchi, Yu
   Kagota, Satomi
   Otsubo, Kazumasa
TI Beneficial effect of coenzyme Q10 on increased oxidative and nitrative
   stress and inflammation and individual metabolic components developing
   in a rat model of metabolic syndrome
SO JOURNAL OF PHARMACOLOGICAL SCIENCES
LA English
DT Article
DE coenzyme Q10; metabolic syndrome model rat; oxidative stress;
   inflammation; endothelial dysfunction
ID LIQUID-CHROMATOGRAPHIC ASSAY; CIRCULATING OXIDIZED LDL;
   LOW-DENSITY-LIPOPROTEIN; SHR/NDMCR-CP RATS; ENDOTHELIAL DYSFUNCTION;
   INSULIN-RESISTANCE; CARDIOVASCULAR-DISEASE; HUMAN PLASMA;
   ATHEROSCLEROSIS; HYPERTENSION
AB Metabolic syndrome (MetS) is a group of cardiovascular risk factors, including visceral obesity, glucose intolerance, hypertension, and dyslipidemia. Increased oxidative and nitrative stress and inflammation and decreased endothelial function occur in an animal model of metabolic syndrome, SHR/NDmcr-cp (SHR/cp) rats. The present study investigated the effects of coenzyme Q 10 (CoQ10), one of the important antioxidants, on the abnormal oxidative condition and characteristic components of metabolic syndrome in SHR/cp rats by maintaining them on a diet supplemented with 0.07% - 0.7% CoQ10 for 26 weeks. We determined serum levels of oxidatively modified low-density lipoprotein (Ox-LDL) and 8-hydroxy-2'-deoxyguanosine (8-OHdG) as oxidative stress markers, 3-nitrotyrosine as a nitrative stress marker, 3-chlorotyrosine as a marker of myeloperoxidase (MPO)-catalyzed oxidation and high-sensitivity C-reactive protein (hsCRP) as an inflammatory marker. The administration of CoQ10 significantly attenuated the increase of oxidative and nitrative stress markers and inflammatory markers in a dose-dependent manner. CoQ10 prevented the elevated serum insulin levels, although it did not affect the elevated glucose level and dyslipidemia. CoQ10 also reduced elevated blood pressure, but did not affect body weight gain. In addition, CoQ10 improved endothelial dysfunction in the mesenteric arteries. These findings suggest that the antioxidant properties of CoQ10 can be effective for ameliorating cardiovascular risk in MetS.
C1 [Kunitomo, Masaru; Yamaguchi, Yu; Kagota, Satomi] Mukogawa Womens Univ, Sch Pharmaceut Sci, Nishinomiya, Hyogo 6638179, Japan.
   [Otsubo, Kazumasa] Asahi Kasei Pharma Corp, Fine Chem Div, Tokyo 1018101, Japan.
C3 Mukogawa Women's University; Asahi Kasei Pharma Corporation
RP Kunitomo, M (corresponding author), Mukogawa Womens Univ, Sch Pharmaceut Sci, Nishinomiya, Hyogo 6638179, Japan.
EM masaru@mukogawa-u.ac.jp
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NR 51
TC 71
Z9 80
U1 0
U2 9
PU JAPANESE PHARMACOLOGICAL SOC
PI KYOTO
PA EDITORIAL OFF, KANTOHYA BLDG GOKOMACHI-EBISUGAWA NAKAGYO-KU, KYOTO, 604,
   JAPAN
SN 1347-8613
EI 1347-8648
J9 J PHARMACOL SCI
JI J. Pharmacol. Sci.
PD JUN
PY 2008
VL 107
IS 2
BP 128
EP 137
DI 10.1254/jphs.FP0072365
PG 10
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 319PA
UT WOS:000257174800003
PM 18544898
OA Bronze
DA 2025-06-11
ER

PT J
AU Ottesen, NM
   Meluken, I
   Frikke-Schmidt, R
   Plomgaard, P
   Scheike, T
   Fernandes, BS
   Berk, M
   Poulsen, HE
   Kessing, LV
   Miskowiak, K
   Vinberg, M
AF Ottesen, Ninja Meinhard
   Meluken, Iselin
   Frikke-Schmidt, Ruth
   Plomgaard, Peter
   Scheike, Thomas
   Fernandes, Brisa S.
   Berk, Michael
   Poulsen, Henrik Enghusen
   Kessing, Lars Vedel
   Miskowiak, Kamilla
   Vinberg, Maj
TI Are remitted affective disorders and familial risk of affective
   disorders associated with metabolic syndrome, inflammation and oxidative
   stress? - a monozygotic twin study
SO PSYCHOLOGICAL MEDICINE
LA English
DT Article
DE Affective disorder; inflammation; metabolic syndrome; monozygotic twins;
   oxidative stress; risk factors
ID MAJOR DEPRESSIVE DISORDER; BIPOLAR DISORDER; INSULIN-RESISTANCE;
   PHYSICAL-ACTIVITY; MENTAL-ILLNESS; METAANALYSIS; OBESITY; PEOPLE;
   PREVALENCE; MECHANISMS
AB Background Metabolic syndrome (MetS) is associated with reduced life expectancy in patients with affective disorders, however, whether MetS also plays a role before the onset of affective disorder is unknown. We aimed to investigate whether MetS, inflammatory markers or oxidative stress act as risk factors for affective disorders, and whether MetS is associated with increased inflammation and oxidative stress. Methods We conducted a high-risk study including 204 monozygotic (MZ) twins with unipolar or bipolar disorder in remission or partial remission (affected), their unaffected co-twins (high-risk) and twins with no personal or family history of affective disorder (low-risk). Metabolic Syndrome was ascertained according to the International Diabetes Federation (IDF) criteria. Inflammatory markers and markers of oxidative stress were analyzed from fasting blood and urine samples, respectively. Results The affected and the high-risk group had a significantly higher prevalence of MetS compared to the low-risk group (20%v.15%v.2.5%,p= 0.0006), even after adjusting for sex, age, smoking and alcohol consumption. No differences in inflammatory and oxidative markers were seen between the three groups. Further, MetS was associated with alterations in inflammatory markers, and oxidative stress was modestly correlated with inflammation. Conclusion Metabolic syndrome is associated with low-grade inflammation and may act as a risk factor and a trait marker for affective disorders. If confirmed in longitudinal studies, this suggests the importance of early intervention and preventive approaches targeted towards unhealthy lifestyle factors that may contribute to later psychopathology.
C1 [Ottesen, Ninja Meinhard; Meluken, Iselin; Kessing, Lars Vedel; Miskowiak, Kamilla; Vinberg, Maj] Rigshosp, Copenhagen Affect Disorders Res Ctr CADIC, Psychiat Ctr Copenhagen, Copenhagen, Denmark.
   [Frikke-Schmidt, Ruth; Plomgaard, Peter] Copenhagen Univ Hosp, Dept Clin Biochem Rigshosp, Copenhagen, Denmark.
   [Frikke-Schmidt, Ruth; Plomgaard, Peter] Copenhagen Univ Hosp, Dept Clin Biochem, Rigshosp, Copenhagen, Denmark.
   [Scheike, Thomas] Univ Copenhagen, Fac Hlth & Med Sci, Dept Clin Med, Copenhagen, Denmark.
   [Fernandes, Brisa S.] Univ Copenhagen, Dept Publ Hlth, Sect Biostat, Copenhagen, Denmark.
   [Berk, Michael] Univ Toronto, Ctr Addict & Mental Hlth CAMH, Toronto, ON, Canada.
   [Berk, Michael] Univ Toronto, Dept Psychiat, Toronto, ON, Canada.
   [Berk, Michael] Deakin Univ, IMPACT Strateg Res Ctr, Sch Med, Geelong, Vic, Australia.
   [Poulsen, Henrik Enghusen] Univ Melbourne, Natl Ctr Excellence Youth Mental Hlth, Orygen, Florey Inst Neurosci & Mental Hlth, Parkville, Vic, Australia.
   [Poulsen, Henrik Enghusen] Univ Melbourne, Dept Psychiat, Parkville, Vic, Australia.
   [Poulsen, Henrik Enghusen] Bispebjerg Frederiksberg Hosp, Dept Clin Pharmacol, Copenhagen, Denmark.
C3 Rigshospitalet; University of Copenhagen; Copenhagen University
   Hospital; University of Copenhagen; Copenhagen University Hospital;
   Rigshospitalet; University of Copenhagen; Copenhagen University
   Hospital; University of Copenhagen; University of Copenhagen; University
   of Toronto; Centre for Addiction & Mental Health - Canada; University of
   Toronto; Deakin University; University of Melbourne; Florey Institute of
   Neuroscience & Mental Health; Orygen, The National Centre of Excellence
   in Youth Mental Health; University of Melbourne; University of
   Copenhagen; Bispebjerg Hospital
RP Ottesen, NM (corresponding author), Rigshosp, Copenhagen Affect Disorders Res Ctr CADIC, Psychiat Ctr Copenhagen, Copenhagen, Denmark.
EM ninja.meinhard.01@regionh.dk
RI Berk, Michael/AGH-9427-2022; Kessing, Lars/JNS-2493-2023;
   Vinberg/ABC-7493-2021; Berk, Michael/M-7891-2013; Fernandes,
   Brisa/B-6614-2009
OI Plomgaard, Peter/0000-0002-2404-2702; Berk, Michael/0000-0002-5554-6946;
   Scheike, Thomas/0000-0002-2148-4740; Kessing, Lars/0000-0001-9377-9436;
   Miskowiak, Kamilla/0000-0003-2572-1384; Frikke-Schmidt,
   Ruth/0000-0003-4084-5027; Fernandes, Brisa/0000-0002-3797-7582
FU Capital Region of Denmark; Augustinus Foundation; Axel Thomsen's
   Foundation; Lundbeck Foundation [R108-A10015]; Hoerslev Foundation;
   Fonden til Laegevidensskabens Fremme; National Health and Medical
   Research Council (NHMRC) Senior Principal Research Fellowship
   [APP1059660, APP1156072]
FX The study was supported by The Capital Region of Denmark, the Augustinus
   Foundation, the Axel Thomsen's Foundation, the Lundbeck Foundation
   (R108-A10015), the Hoerslev Foundation, and Fonden til
   Laegevidensskabens Fremme. MB is supported by a National Health and
   Medical Research Council (NHMRC) Senior Principal Research Fellowship
   (APP1059660 and APP1156072). The sponsors had no role in the planning or
   conduct of the study or in the interpretation of the results.
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NR 78
TC 14
Z9 14
U1 0
U2 8
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0033-2917
EI 1469-8978
J9 PSYCHOL MED
JI Psychol. Med.
PD JUL
PY 2020
VL 50
IS 10
BP 1736
EP 1745
AR PII S003329171900182X
DI 10.1017/S003329171900182X
PG 10
WC Psychology, Clinical; Psychiatry; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA MZ8US
UT WOS:000559400500016
PM 31482770
DA 2025-06-11
ER

PT J
AU Singh, M
AF Singh, Minati
TI Mood, food, and obesity
SO FRONTIERS IN PSYCHOLOGY
LA English
DT Review
DE mood; depression; anxiety; food; obesity
ID SEROTONIN 2C RECEPTOR; POLYUNSATURATED FATTY-ACID; SEASONAL
   AFFECTIVE-DISORDER; MAJOR DEPRESSIVE DISORDER; STRESS-INDUCED OBESITY;
   CHRONIC SOCIAL STRESS; SERUM LEPTIN LEVELS; INSULIN-RESISTANCE;
   METABOLIC SYNDROME; PLASMA LEPTIN
AB Food is a potent natural reward and food intake is a complex process. Reward and gratification associated with food consumption leads to dopamine (DA) production, which in turn activates reward and pleasure centers in the brain. An individual will repeatedly eat a particular food to experience this positive feeling of gratification. This type of repetitive behavior of food intake leads to the activation of brain reward pathways that eventually overrides other signals of satiety and hunger. Thus, a gratification habit through a favorable food leads to overeating and morbid obesity. Overeating and obesity stems from many biological factors engaging both central and peripheral systems in a bi-directional manner involving mood and emotions. Emotional eating and altered mood can also lead to altered food choice and intake leading to overeating and obesity. Research findings from human and animal studies support a two-way link between three concepts, mood, food, and obesity. The focus of this article is to provide an overview of complex nature of food intake where various biological factors link mood, food intake, and brain signaling that engages both peripheral and central nervous system signaling pathways in a bi-directional manner in obesity.
C1 [Singh, Minati] Univ Iowa, Dept Pediat, Iowa City, IA 52242 USA.
   [Singh, Minati] Univ Iowa, Dept Pediat, HHMI, Iowa City, IA 52242 USA.
C3 University of Iowa; Howard Hughes Medical Institute; University of Iowa
RP Singh, M (corresponding author), Univ Iowa, Dept Pediat, HHMI, 4181 MERF, Iowa City, IA 52242 USA.
EM minati-singh@uiowa.edu
OI Singh, Minati/0000-0001-7307-2628
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NR 392
TC 257
Z9 286
U1 2
U2 193
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-1078
J9 FRONT PSYCHOL
JI Front. Psychol.
PD SEP 1
PY 2014
VL 5
AR 925
DI 10.3389/fpsyg.2014.00925
PG 20
WC Psychology, Multidisciplinary
WE Social Science Citation Index (SSCI)
SC Psychology
GA AO8FQ
UT WOS:000341589300001
PM 25225489
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Stalder, T
   Kirschbaum, C
   Alexander, N
   Bornstein, SR
   Gao, W
   Miller, R
   Stark, S
   Bosch, JA
   Fischer, JE
AF Stalder, Tobias
   Kirschbaum, Clemens
   Alexander, Nina
   Bornstein, Stefan R.
   Gao, Wei
   Miller, Robert
   Stark, Sabine
   Bosch, Jos A.
   Fischer, Joachim E.
TI Cortisol in Hair and the Metabolic Syndrome
SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Article
ID LOW-BIRTH-WEIGHT; SALIVARY CORTISOL; SERUM CORTISOL; BODY-MASS;
   ASSOCIATION; RISK; STRESS; PLASMA; CHOLESTEROL; RESISTANCE
AB Context: Although exposure to supraphysiological levels of glucocorticoids is known to contribute to the development of the metabolic syndrome (MetS), the importance of physiological variation in basal cortisol secretion is less clear. This issue can be addressed by using hair cortisol analysis, which for the first time allows the assessment of long-term integrated hormone levels.
   Objective and Design: We used the analysis of cortisol in hair (hairF) to examine associations of long-term cortisol levels with prevalence of MetS and individual cardiometabolic parameters in a large occupational cohort. In additional exploratory analyses, we also studied cardiometabolic associations with hair cortisone levels.
   Participants: Participants included 1258 employees of a large aerospace company (aged 16-64 years; 84.8% males) who partook in a voluntary health assessment.
   Main Outcome Measures: The first 3 cm of scalp-near hair were analyzed for glucocorticoid concentrations using liquid chromatography tandem mass spectrometry. Relevant cardiometabolic risk factors were assessed and MetS was diagnosed (according to 2009 international task force criteria).
   Results: A higher prevalence of MetS was seen in individuals falling into the third (odds ratio 1.71, 95% confidence interval 1.08-2.69) or fourth hairF quartile (odds ratio 2.42, 95% confidence interval 1.55-3.75) compared with the first quartile, in fully adjusted analyses. HairF also showed positive associations with weight-related anthropometric measures (body mass index, waist to hip ratio, waist circumference) and glycated hemoglobin. The exploratory analysis of hair cortisone also indicated relevant associations with cardiometabolic parameters.
   Conclusion: Normal physiological differences in long-term cortisol secretion, as assessed in hair, show relevant relationships with MetS and individual cardiometabolic parameters.
C1 [Stalder, Tobias; Kirschbaum, Clemens; Alexander, Nina; Gao, Wei; Miller, Robert] Tech Univ Dresden, Dept Psychol, D-01069 Dresden, Germany.
   [Bornstein, Stefan R.] Tech Univ Dresden, Dept Internal Med, D-01307 Dresden, Germany.
   [Gao, Wei] Southeast Univ, Res Ctr Learning Sci, Key Lab Child Dev & Learning Sci, Nanjing 210096, Jiangsu, Peoples R China.
   [Stark, Sabine] Free Univ Berlin, Dept Psychol, D-14195 Berlin, Germany.
   [Bosch, Jos A.] Univ Amsterdam, Dept Clin Psychol, NL-1018 XA Amsterdam, Netherlands.
   [Bosch, Jos A.; Fischer, Joachim E.] Heidelberg Univ, Mannheim Inst Publ Hlth, D-68167 Mannheim, Germany.
C3 Technische Universitat Dresden; Technische Universitat Dresden;
   Southeast University - China; Free University of Berlin; University of
   Amsterdam; Ruprecht Karls University Heidelberg
RP Stalder, T (corresponding author), Tech Univ Dresden, Dept Psychol, Zellescher Weg 19, D-01069 Dresden, Germany.
EM stalder@biopsych.tu-dresden.de
RI Bosch, Jos/AAC-9408-2019; Kirschbaum, Clemens/AAB-1752-2020; Miller,
   Robert/G-4473-2016
OI Miller, Robert/0000-0002-8665-5248; Stalder, Tobias/0000-0001-7558-1274;
   Alexander, Nina/0009-0002-7412-0163
FU German Research Foundation [KI 537/31-1]
FX This work was supported by Grant KI 537/31-1 from the German Research
   Foundation.
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NR 41
TC 199
Z9 217
U1 0
U2 42
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0021-972X
EI 1945-7197
J9 J CLIN ENDOCR METAB
JI J. Clin. Endocrinol. Metab.
PD JUN
PY 2013
VL 98
IS 6
BP 2573
EP 2580
DI 10.1210/jc.2013-1056
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 155GS
UT WOS:000319736500066
PM 23585660
OA Bronze
DA 2025-06-11
ER

PT J
AU Van Etten, EJ
   Knoff, AA
   Colaizzi, TA
   Knight, AR
   Milberg, WP
   Fortier, CB
   Leritz, EC
   Salat, DH
AF Van Etten, Emily J.
   Knoff, Aubrey A.
   Colaizzi, Tristan A.
   Knight, Arielle R.
   Milberg, William P.
   Fortier, Catherine B.
   Leritz, Elizabeth C.
   Salat, David H.
TI Association between metabolic syndrome and white matter integrity in
   young and mid-age post-9/11 adult Veterans
SO CEREBRAL CORTEX
LA English
DT Article
DE metabolic syndrome; vascular risk; white matter integrity; diffusion
   tensor imaging; magnetic resonance imaging; high-density lipoprotein
   cholesterol
ID POSTTRAUMATIC-STRESS-DISORDER; TRAUMATIC BRAIN-INJURY;
   CARDIOVASCULAR-DISEASE; DIFFERENTIAL ASSOCIATIONS; CORTICAL THICKNESS;
   SPATIAL STATISTICS; BLOOD-PRESSURE; RISK-FACTORS; MICROSTRUCTURE;
   CHOLESTEROL
AB Metabolic syndrome has been associated with reduced brain white matter integrity in older individuals. However, less is known about how metabolic syndrome might impact white matter integrity in younger populations. This study examined metabolic syndrome-related global and regional white matter integrity differences in a sample of 537 post-9/11 Veterans. Metabolic syndrome was defined as >= 3 factors of: increased waist circumference, hypertriglyceridemia, low high-density lipoprotein cholesterol, hypertension, and high fasting glucose. T1 and diffusion weighted 3 T MRI scans were processed using the FreeSurfer image analysis suite and FSL Diffusion Toolbox. Atlas-based regions of interest were determined from a combination of the Johns Hopkins University atlas and a Tract-Based Spatial Statistics-based FreeSurfer WMPARC white matter skeleton atlas. Analyses revealed individuals with metabolic syndrome (n = 132) had significantly lower global fractional anisotropy than those without metabolic syndrome (n = 405), and lower high-density lipoprotein cholesterol levels was the only metabolic syndrome factor significantly related to lower global fractional anisotropy levels. Lobe-specific analyses revealed individuals with metabolic syndrome had decreased fractional anisotropy in frontal white matter regions compared with those without metabolic syndrome. These findings indicate metabolic syndrome is prevalent in this sample of younger Veterans and is related to reduced frontal white matter integrity. Early intervention for metabolic syndrome may help alleviate adverse metabolic syndrome-related brain and cognitive effects with age.
C1 [Van Etten, Emily J.; Knoff, Aubrey A.; Colaizzi, Tristan A.; Knight, Arielle R.; Milberg, William P.; Fortier, Catherine B.; Salat, David H.] VA Boston Healthcare Syst, Translat Res Ctr TBI & Stress Disorders TRACTS, Boston, MA 02130 USA.
   [Van Etten, Emily J.; Knoff, Aubrey A.; Milberg, William P.; Fortier, Catherine B.; Leritz, Elizabeth C.] Harvard Med Sch, Dept Psychiat, Boston, MA 02115 USA.
   [Van Etten, Emily J.; Knoff, Aubrey A.] Boston Univ, Chobanian & Avedisian Sch Med, Dept Psychiat, Boston, MA 02118 USA.
   [Milberg, William P.; Fortier, Catherine B.; Leritz, Elizabeth C.; Salat, David H.] VA Boston Healthcare Syst, Geriatr Res Educ & Clin Ctr GRECC, Boston, MA 02130 USA.
   [Leritz, Elizabeth C.] VA Boston Healthcare Syst, Boston, MA 02130 USA.
   [Salat, David H.] VA Boston Healthcare Syst, Neuroimaging Res Vet Ctr, Boston, MA 02130 USA.
   [Salat, David H.] Anthinoula A Martinos Ctr Biomed Imaging, Boston, MA 02129 USA.
C3 Harvard University; Harvard University Medical Affiliates; US Department
   of Veterans Affairs; Veterans Health Administration (VHA); VA Boston
   Healthcare System; Harvard University; Harvard Medical School; Boston
   University; Geriatric Research Education & Clinical Center; Harvard
   University; Harvard University Medical Affiliates; US Department of
   Veterans Affairs; Veterans Health Administration (VHA); VA Boston
   Healthcare System; Harvard University; Harvard University Medical
   Affiliates; US Department of Veterans Affairs; Veterans Health
   Administration (VHA); VA Boston Healthcare System; Harvard University;
   Harvard University Medical Affiliates; US Department of Veterans
   Affairs; Veterans Health Administration (VHA); VA Boston Healthcare
   System
RP Van Etten, EJ (corresponding author), VA Boston Healthcare Syst, TRACTS 182-JP,150 S Huntington Ave, Boston, MA 02130 USA.
EM Emily.VanEtten@va.gov; Aubrey.Knoff@va.gov; colaizzi.tristan@gmail.com;
   ariellerose46@gmail.com; wpm2@me.com; catherine_fortier@hms.harvard.edu;
   elizabeth.leritz@va.gov; dsalat@mgh.harvard.edu
RI Van Etten, Emily/LRC-3140-2024; Fortier, Catherine/AAS-2163-2021
OI Fortier, Catherine/0000-0002-8953-9904; Van Etten,
   Emily/0000-0003-1587-2138
FU Translational Research Center for TBI and Stress Disorders (TRACTS)
   [B3001-C]; VA Office of Rehabilitation, Research and Development
   [RX004535, RX002907]; Office of Academic Affiliations, US Department of
   Veterans Affairs
FX This research was supported by the Translational Research Center for TBI
   and Stress Disorders (TRACTS), which is a VA Rehabilitation Research and
   Development Traumatic Brain Injury National Network Center (B3001-C).
   C.B.F. received funding from the VA Office of Rehabilitation, Research
   and Development (Merit Review to CBF RX004535 & RX002907). This material
   is based upon work done as part of the Inter professional Polytrauma and
   Traumatic Brain Injury Rehabilitation Research Fellowship supported by
   the Office of Academic Affiliations, US Department of Veterans Affairs
   (EVE). The contents of this manuscript do not represent the views of the
   US Department of Veterans Affairs or the United States Government.
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NR 56
TC 0
Z9 0
U1 0
U2 0
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1047-3211
EI 1460-2199
J9 CEREB CORTEX
JI Cereb. Cortex
PD AUG 16
PY 2024
VL 34
IS 8
AR bhae340
DI 10.1093/cercor/bhae340
PG 8
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA C8O3G
UT WOS:001291901400002
PM 39152671
DA 2025-06-11
ER

PT J
AU Murrow, JR
   Sher, S
   Au, S
   Uphoff, I
   Patel, R
   Porkert, M
   Le, NA
   Jones, D
   Quyyumi, AA
AF Murrow, Jonathan R.
   Sher, Salman
   Au, Sarfraz
   Uphoff, Irina
   Patel, Riyaz
   Porkert, Marcus
   Ngoc-Anh Le
   Jones, Dean
   Quyyumi, Arshed A.
TI The differential effect of statins on oxidative stress and endothelial
   function: Atorvastatin versus pravastatin
SO JOURNAL OF CLINICAL LIPIDOLOGY
LA English
DT Article
DE Endothelial function; Metabolic syndrome; Oxidative stress; Statins
ID HYPERCHOLESTEROLEMIC PATIENTS; METABOLIC SYNDROME; HEALTHY-ADULTS;
   IN-VIVO; DISEASE; MARKERS; PLASMA; INFLAMMATION; BIOMARKERS; ARTERY
AB BACKGROUND: Atherogenic risk in subjects with metabolic syndrome is partly mediated by increased oxidative stress and subsequent endothelial dysfunction. Clinical trials have demonstrated differences in outcomes between subjects receiving lipophilic statins (atorvastatin) compared with hydrophilic statins (pravastatin). However, whether these findings are attributable to differences in the doses administered or to nonlipid-lowering pleiotropic effects of statins on oxidative stress and vascular function remains unknown. We hypothesized that equipotent doses of these two statins will have divergent effects on markers of oxidative stress and endothelial function.
   METHODS: Thirty-six subjects with hyperlipidemia and metabolic syndrome and/or diabetes were randomized in a double-blind manner to either pravastatin 80 mg or atorvastatin 10 mg daily. Oxidative stress (dROMs assay that measures lipid hydroperoxides, plasma thiobarbituric acid reactive substances [MARS], and aminothiol levels) and brachial artery flow-mediated dilation (FMD) were measured at baseline and after 12 weeks of statin therapy.
   RESULTS: Statin therapy reduced serum low-density lipoprotein cholesterol levels equally in both groups. Atorvastatin therapy was associated with a significant reduction in TBARS (P = .006) and dROMs levels (P = .02), which was not observed in subjects treated with pravastatin. Endothelial function improved with statin therapy (P = .02), but there was no difference between the statin groups.
   CONCLUSION: In hyperlipidemic subjects with metabolic syndrome, atorvastatin is associated with a greater reduction in lipid markers of oxidation compared with pravastatin. Whether these effects are responsible for the outcome differences in trials comparing these agents needs further investigation. (C) 2012 National Lipid Association. All rights reserved.
C1 [Murrow, Jonathan R.; Sher, Salman; Au, Sarfraz; Uphoff, Irina; Patel, Riyaz; Porkert, Marcus; Ngoc-Anh Le; Jones, Dean; Quyyumi, Arshed A.] Emory Univ, Sch Med, Atlanta, GA 30322 USA.
C3 Emory University
RP Murrow, JR (corresponding author), Emory Univ, Sch Med, 1364 Clifton Rd,Suite D403C, Atlanta, GA 30322 USA.
EM jmurrow@emory.edu
OI Le, Ngoc-Anh/0000-0002-2634-4798
FU Pfizer; Pfizer, Inc. (New York, NY)
FX Dr. Quyyumi received research funding from Pfizer, which manufactures
   Atorvastatin, a product related to the research described in this paper.
   In addition, the author has received honoraria as a consultant to
   Pfizer. The terms of this arrangement have been reviewed and approved by
   Emory University in accordance with its conflict of interest policies.
   This study was funded in part by a grant from Pfizer, Inc. (New York,
   NY).
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NR 32
TC 59
Z9 64
U1 0
U2 3
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1933-2874
J9 J CLIN LIPIDOL
JI J. Clin. Lipidol.
PD FEB
PY 2012
VL 6
IS 1
BP 42
EP 49
DI 10.1016/j.jacl.2011.08.006
PG 8
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 886KB
UT WOS:000299852200006
PM 22264573
DA 2025-06-11
ER

PT J
AU Wang, C
   Blough, ER
   Arvapalli, R
   Dai, XN
   Paturi, S
   Manne, N
   Addagarla, H
   Triest, WE
   Olajide, O
   Wu, MZ
AF Wang, Cuifen
   Blough, Eric R.
   Arvapalli, Ravikumar
   Dai, Xiaoniu
   Paturi, Satyanarayana
   Manne, Nandini
   Addagarla, Hari
   Triest, William E.
   Olajide, Omolola
   Wu, Miaozong
TI Metabolic syndrome-induced tubulointerstitial injury: Role of oxidative
   stress and preventive effects of acetaminophen
SO FREE RADICAL BIOLOGY AND MEDICINE
LA English
DT Article
DE Metabolic syndrome; Tubulointerstitial injury; Acetaminophen; Oxidative
   stress; Epithelial-to-mesenchymal transition; Cell death
ID EPITHELIAL-MESENCHYMAL TRANSITION; KIDNEY-DISEASE; NADPH OXIDASE;
   OBESITY; ACTIVATION; INHIBITOR; MARKERS; PLAYS; MODEL; BETA
AB The prevalence of metabolic syndrome persistently increases and affects over 30% of U.S. adults. To study how metabolic syndrome may induce tubulointerstitial injury and whether acetaminophen has renal-protective properties, 4-week-old obese Zucker rats were randomly assigned into three groups, control (OC), vehicle dimethyl sulfoxide (OV), and acetaminophen treatment (30 mg/kg/day for 26 weeks), and lean Zucker rats served as healthy controls. Significant tubulointerstitial injuries were observed in both OC and OV animals, evidenced by increased tubular cell death, tubular atrophy/dilation, inflammatory cell infiltration, and fibrosis. These tubulointerstitial alterations were significantly reduced by treatment with a chronic but low dose of acetaminophen, which acted to diminish NADPH oxidase isoforms Nox2 and Nox4 and decrease tubulointerstitial oxidative stress (reduced tissue superoxide and macromolecular oxidation). Decreased oxidative stress by acetaminophen was paralleled by the reduction of tubular proapoptotic signaling (diminished Bax/BcI-2 ratio and caspase 3 activation) and the alleviation of tubular epithelial-to-mesenchymal transition (decreased transforming growth factor beta, connective tissue growth factor, alpha-smooth muscle actin, and laminin). These data suggest that increased oxidative stress plays a critical role in mediating metabolic syndrome-induced tubulointerstitial injury and provide the first evidence suggesting that acetaminophen may be of therapeutic benefit for the prevention of tubulointerstitial injury. (C) 2013 The Authors. Published by Elsevier Inc. All rights reserved.
C1 [Wang, Cuifen; Blough, Eric R.; Arvapalli, Ravikumar; Paturi, Satyanarayana; Manne, Nandini; Addagarla, Hari; Wu, Miaozong] Marshall Univ, Ctr Diagnost Nanosyst, Huntington, WV 25755 USA.
   [Wang, Cuifen; Blough, Eric R.; Arvapalli, Ravikumar; Wu, Miaozong] Marshall Univ, Sch Pharm, Huntington, WV 25755 USA.
   [Wang, Cuifen; Dai, Xiaoniu] Southeast Univ, Nanjing, Jiangsu, Peoples R China.
   [Manne, Nandini; Olajide, Omolola; Wu, Miaozong] Marshall Univ, Joan C Edwards Sch Med, Huntington, WV 25755 USA.
   [Triest, William E.] Huntington Vet Affairs Med Ctr, Huntington, WV 25704 USA.
C3 Marshall University; Marshall University; Southeast University - China;
   Marshall University
RP Blough, ER (corresponding author), Marshall Univ, Ctr Diagnost Nanosyst, Huntington, WV 25755 USA.
EM blough@marshall.edu; wum@marshall.edu
RI Manne, Nandini/ABD-5834-2021; Wu, Miaozong/C-1344-2009
OI Manne, Nandini/0000-0001-9159-0090
FU Department of Energy [DE-SC0005162]; U.S. Department of Energy (DOE)
   [DE-SC0005162] Funding Source: U.S. Department of Energy (DOE)
FX This work was supported by Department of Energy Grant DE-SC0005162 to
   E.R.B. The funder had no role in study design, data collection and
   analysis, preparation of the manuscript, or decision to publish. The
   authors acknowledge the support of the Huntington VA Medical Center and
   the Joan C. Edwards School of Medicine Training Program in Endocrinology
   for laboratory space and equipment. We thank Mr. Kevin Rice and
   Srinivasarao Thulluri for their technical support.
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NR 44
TC 23
Z9 26
U1 0
U2 5
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0891-5849
EI 1873-4596
J9 FREE RADICAL BIO MED
JI Free Radic. Biol. Med.
PD DEC
PY 2013
VL 65
BP 1417
EP 1426
DI 10.1016/j.freeradbiomed.2013.10.005
PG 10
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 278DI
UT WOS:000328868900136
PM 24140865
OA hybrid
DA 2025-06-11
ER

PT J
AU Björntorp, P
AF Björntorp, P
TI Heart and soul:: Stress and the metabolic syndrome
SO SCANDINAVIAN CARDIOVASCULAR JOURNAL
LA English
DT Review
ID BODY-FAT DISTRIBUTION; OBESITY; HYPERTENSION; CORTISOL; MECHANISMS;
   RESPONSES; LEPTIN; MEN
C1 Univ Gothenburg, Sahlgrens Hosp, Cardiovasc Inst, SE-41345 Gothenburg, Sweden.
C3 Sahlgrenska University Hospital; University of Gothenburg
RP Björntorp, P (corresponding author), Univ Gothenburg, Sahlgrens Hosp, Cardiovasc Inst, SE-41345 Gothenburg, Sweden.
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NR 33
TC 40
Z9 48
U1 0
U2 4
PU TAYLOR & FRANCIS AS
PI OSLO
PA CORT ADELERSGT 17, PO BOX 2562, SOLLI, 0202 OSLO, NORWAY
SN 1401-7431
J9 SCAND CARDIOVASC J
JI Scand. Cardiovasc. J.
PD JUL
PY 2001
VL 35
IS 3
BP 172
EP 177
DI 10.1080/140174301750305045
PG 6
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 459FV
UT WOS:000170241100003
PM 11515689
DA 2025-06-11
ER

PT J
AU Nawrocka, D
   Kornicka, K
   Smieszek, A
   Marycz, K
AF Nawrocka, Daria
   Kornicka, Katarzyna
   Smieszek, Agnieszka
   Marycz, Krzysztof
TI Spirulina platensis Improves Mitochondrial Function Impaired by
   Elevated Oxidative Stress in Adipose-Derived Mesenchymal Stromal Cells
   (ASCs) and Intestinal Epithelial Cells (IECs), and Enhances Insulin
   Sensitivity in Equine Metabolic Syndrome (EMS) Horses
SO MARINE DRUGS
LA English
DT Article
DE Spirulina platensis; equine metabolic syndrome; mesenchymal stromal
   cells; intestinal epithelial cells; oxidative stress; inflammation;
   insulin resistance
ID ANTIINFLAMMATORY ACTIVITIES; REACTIVE OXYGEN; C-PHYCOCYANIN;
   CYTOCHROME-C; STEM-CELLS; ANTIOXIDANT; TISSUE; INFLAMMATION; MITOPHAGY;
   PROTECTS
AB Equine Metabolic Syndrome (EMS) is a steadily growing life-threatening endocrine disorder linked to insulin resistance, oxidative stress, and systemic inflammation. Inflammatory microenvironment of adipose tissue constitutes the direct tissue milieu for various cell populations, including adipose-derived mesenchymal stromal cells (ASCs), widely considered as a potential therapeutic cell source in the course of the treatment of metabolic disorders. Moreover, elevated oxidative stress induces inflammation in intestinal epithelial cells (IECs)-the first-line cells exposed to dietary compounds. In the conducted research, we showed that in vitro application of Spirulina platensis contributes to the restoration of ASCs' and IECs' morphology and function through the reduction of cellular oxidative stress and inflammation. Enhanced viability, suppressed senescence, and improved proliferation of ASCs and IECs isolated from metabolic syndrome-affected individuals were evident following exposition to Spirulina. A protective effect of the investigated extract against mitochondrial dysfunction and degeneration was also observed. Moreover, our data demonstrate that Spirulina extract effectively suppressed LPS-induced inflammatory responses in macrophages. In vivo studies showed that horses fed with a diet based on Spirulina platensis supplementation lost weight and their insulin sensitivity improved. Thus, our results indicate the engagement of Spirulina platensis nourishing as an interesting alternative approach for supporting the conventional treatment of equine metabolic syndrome.
C1 [Nawrocka, Daria; Kornicka, Katarzyna; Smieszek, Agnieszka; Marycz, Krzysztof] Univ Environm & Life Sci, Fac Biol & Anim Sci, Dept Expt Biol, 27b Norwida Str, PL-50375 Wroclaw, Poland.
   [Kornicka, Katarzyna; Marycz, Krzysztof] Wroclaw Res Ctr EIT, Stablowicka Str 147, PL-54066 Wroclaw, Poland.
C3 Wroclaw University of Environmental & Life Sciences
RP Marycz, K (corresponding author), Univ Environm & Life Sci, Fac Biol & Anim Sci, Dept Expt Biol, 27b Norwida Str, PL-50375 Wroclaw, Poland.; Marycz, K (corresponding author), Wroclaw Res Ctr EIT, Stablowicka Str 147, PL-54066 Wroclaw, Poland.
EM daria.k.nawrocka@gmail.com; kornicka.katarzyna@gmail.com;
   smieszek.agnieszka@gmail.com; krzysztofmarycz@interia.pl
RI Nawrocka, Daria/IAN-5592-2023; Nawrocka, Daria/B-5026-2017; Smieszek,
   Agnieszka/A-4887-2017
OI Nawrocka, Daria/0000-0002-1257-4146; Smieszek,
   Agnieszka/0000-0002-7314-9821
FU Wroclaw Centre of Biotechnology, programme the Leading National Research
   Centre (KNOW); National Science Centre in Poland [2015/18/E/NZ9/00607,
   2016/21/B/NZ7/01111]
FX This project is financed in the framework of grant entitled-"The effect
   of bioactive algae enriched by biosorption on the certain minerals such
   as Cr(III), Mg(II) and Mn(II) on the status of glucose in the course of
   metabolic syndrome horses. Evaluation in vitro and in vivo"
   (2015/18/E/NZ9/00607) and grant entitled "The combined effect of
   resveratrol and 5-azacatidine in vitro, as a demethylative and
   anti-aging factors on Equine metabolic syndrome adipose derived stromal
   stem cells (ASCems)" (2016/21/B/NZ7/01111). Both grants are attributed
   by The National Science Centre in Poland. The publication is supported
   by Wroclaw Centre of Biotechnology, programme the Leading National
   Research Centre (KNOW) for years 2014-2018.
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NR 78
TC 60
Z9 62
U1 0
U2 26
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1660-3397
J9 MAR DRUGS
JI Mar. Drugs
PD AUG
PY 2017
VL 15
IS 8
AR 237
DI 10.3390/md15080237
PG 28
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA FF2YT
UT WOS:000408763400003
PM 28771165
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Liu, Y
   Chen, HE
   Mu, D
   Fan, JH
   Song, JY
   Zhong, Y
   Li, D
   Xia, M
AF Liu, Yan
   Chen, Hongen
   Mu, Di
   Fan, Jiahua
   Song, Jiayi
   Zhong, Yuan
   Li, Di
   Xia, Min
TI Circulating Retinoic Acid Levels and the Development of Metabolic
   Syndrome
SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Article
ID INFLAMMATORY MARKERS; INSULIN-RESISTANCE; OXIDATIVE STRESS; X-RECEPTOR;
   OBESITY; ADIPONECTIN; PROTEIN; ADIPOGENESIS; MECHANISMS; COMPONENTS
AB Context and Objective: In this prospective study, we evaluated the association of retinoic acid (RA) with the metabolic syndrome (MetS) in the Chinese population.
   Design and Participants: A total of 1042 nondiabetic adults from the population-based Nutrition and Health of Aging Population were prospectively followed up for 4 years. Serum RA concentrations was determined and its relationship with the MetS and its component was investigated.
   Results: At baseline, higher RA levels were inversely associated with the presence of MetS (odds ratio 0.61; 95% confidence interval [CI] 0.44-0.74, P < .001) after adjustment for age, gender, body mass index, the homeostasis model assessment index for insulin resistance (HOMA-IR), and other confounding factors. Subjects with lower RA levels had a progressively worse cardiometabolic risk profile at baseline. Serum RA levels were inversely associated with 8-iso-prostaglandin F2 alpha (P < .001), high-sensitivity C-reactive protein (P < .015), and IL-6 (P < .020) and positively correlated with high-density lipoprotein cholesterol (P < .038). Among 825 subjects without MetS at baseline, 146 had developed it at 4 years. Serum RA by quartiles was inversely correlated with the incident MetS (adjusted hazard ratio 0.67; 95% CI 0.48-0.81, P = .006). Apart from HOMA-IR (P < .001), the baseline RA level was the only independent predictor of the development of the MetS during the 4-year follow-up (odds ratio 0.53; 95% CI 0.40-0.69; P < .001) after adjustment for age, gender, body mass index, and HOMA-IR.
   Conclusions: The serum RA level is inversely associated with the development of MetS independently of adiposity and insulin resistance.
C1 [Liu, Yan; Chen, Hongen; Mu, Di; Fan, Jiahua; Song, Jiayi; Zhong, Yuan; Li, Di; Xia, Min] Sun Yat Sen Univ, Sch Publ Hlth, Dept Nutr, Guangdong Prov Key Lab Food Nutr & Hlth, Northern Campus, Guangzhou 510080, Guangdong, Peoples R China.
C3 Sun Yat Sen University
RP Xia, M (corresponding author), Sun Yat Sen Univ, Sch Publ Hlth, Dept Nutr, Northern Campus, Guangzhou 510080, Guangdong, Peoples R China.
EM xiamin@mail.sysu.edu.cn
OI Qu, Yi/0000-0002-9993-8810
FU Guangzhou Science and Technology Innovation Committee [201510010220]
FX This work was supported by the Guangzhou Science and Technology
   Innovation Committee (Grant 201510010220).
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NR 41
TC 29
Z9 29
U1 0
U2 12
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0021-972X
EI 1945-7197
J9 J CLIN ENDOCR METAB
JI J. Clin. Endocrinol. Metab.
PD APR
PY 2016
VL 101
IS 4
BP 1686
EP 1692
DI 10.1210/jc.2015-4038
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA DU0YP
UT WOS:000381931400042
PM 26863424
OA Bronze
DA 2025-06-11
ER

PT J
AU Ljubicic, R
   Jakovac, H
   Bistrovic, IL
   Franceski, T
   Mufic, AK
   Karlovic, D
AF Ljubicic, Rudolf
   Jakovac, Hrvoje
   Bistrovic, Ivana Ljubicic
   Franceski, Tanja
   Mufic, Ana Kovak
   Karlovic, Dalibor
TI Prevalence of Metabolic Syndrome among Patients with Major Depressive
   Disorder - Differences Between Newly Diagnosed First Episode and
   Recurrent Disease
SO COLLEGIUM ANTROPOLOGICUM
LA English
DT Article
DE major depressive disorder; first episode; recurrent; metabolic syndrome;
   NCEP-ATP III; prevalence
ID SYMPTOMS; HEALTH; INFLAMMATION; MORTALITY
AB The objective of the present study was to assess differences in prevalence of the metabolic syndrome among depressed patients in regard to the duration of the illness (first episode versus recurrent episodes). A total of 190 patients suffering from major depressive disorder were included in the study, diagnosed according to International classification of disorders, 10th revision(1). The same criteria were used to divide participants into two groups: first episode major depressive disorder and major depressive disorder with recurrent episodes. The metabolic syndrome was defined according to the criteria of the American National Cholesterol Education Program-Treatment Panel III2. Results showed that metabolic syndrome is significantly more prevalent in patients with recurrent major depressive disorder (45.2%) compared to patients with first episode of major depressive disorder (27.3%), mainly due to differences in plasma glucose, triglycerides and HDL-cholesterol levels. These findings indicate the importance of the duration of depression and the number of recurring episodes as factors involved in etiopathogenesis of the associated metabolic syndrome.
C1 [Ljubicic, Rudolf; Franceski, Tanja; Mufic, Ana Kovak; Karlovic, Dalibor] Univ Zagreb, Dept Psychiat, Univ Hosp Ctr Sestre Milosrdnice, Zagreb 10000, Croatia.
   [Jakovac, Hrvoje] Univ Rijeka, Sch Med, Dept Physiol & Immunol, Rijeka, Croatia.
   [Bistrovic, Ivana Ljubicic] Univ Rijeka, Univ Hosp Ctr Rijeka, Dept Psychiat, Rijeka, Croatia.
C3 University of Zagreb; University of Rijeka; University of Rijeka
RP Ljubicic, R (corresponding author), Univ Zagreb, Dept Psychiat, Univ Hosp Ctr Sestre Milosrdnice, Vinogradska Cesta 29, Zagreb 10000, Croatia.
EM rudolf.ljubicic@yahoo.com
RI Bistrović, Ivana/O-7208-2019; Jakovac, Hrvoje/P-6514-2018
OI Jakovac, Hrvoje/0000-0001-8174-5124; Ljubicic Bistrovic,
   Ivana/0000-0003-2567-6915
CR [Anonymous], 2004, The International Statistical Classification of Diseases and Health Related Problems ICD-10: Tenth Revision
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NR 27
TC 5
Z9 5
U1 0
U2 5
PU COLLEGIUM ANTROPOLOGICUM
PI ZAGREB
PA INST ANTHROPOLOGICAL RESEARCH, GAJEVA 32, PO BOX 290, HR-10000 ZAGREB,
   CROATIA
SN 0350-6134
J9 COLLEGIUM ANTROPOL
JI Coll. Anthropol.
PD DEC
PY 2013
VL 37
IS 4
BP 1065
EP 1069
PG 5
WC Anthropology
WE Social Science Citation Index (SSCI)
SC Anthropology
GA 301UG
UT WOS:000330557000003
PM 24611316
DA 2025-06-11
ER

PT J
AU Huang, JYH
   Gariépy, G
   Gavin, AR
   Rowhani-Rahbar, A
   Siscovick, DS
   Enquobahrie, DA
AF Huang, Jonathan Yinhao
   Gariepy, Genevieve
   Gavin, Amelia R.
   Rowhani-Rahbar, Ali
   Siscovick, David S.
   Enquobahrie, Daniel A.
TI Maternal Education in Early Life and Risk of Metabolic Syndrome in Young
   Adult American Females and Males Disentangling Life Course Processes
   Through Causal Models
SO EPIDEMIOLOGY
LA English
DT Article
ID MARGINAL STRUCTURAL MODELS; SOCIOECONOMIC-STATUS; CHRONIC DISEASE;
   BIRTH-WEIGHT; CARDIOVASCULAR-DISEASE; CARDIOMETABOLIC RISK; HEALTH;
   BIAS; EXPOSURE; STRESS
AB Background: Maternal education in a child's early life may directly affect the child's adult cardiometabolic health, but this is difficult to disentangle from biological, social, and behavioral life course processes that are associated with maternal education. These processes may also differ between males and females. Methods: Using data from the National Longitudinal Study of Adolescent to Adult Health (1995-2009) (N = 4,026 females and 3,192 males), we estimated sex-stratified associations between maternal attainment of less than high school (<HS), high school diploma (HS), or college degree (CD) at the respondent's birth and respondent's risk of metabolic syndrome (MetS); we used marginal structural models (MSM) to account for the influence of major life course risk factors, such as childhood maltreatment, adolescent overweight, adult education, household income, smoking, and physical activity, in mediating associations between maternal education and offspring MetS risk. Results: Each higher level of maternal education was associated with a 36% (Relative Risk = 0.64 [95% Confidence Interval (CI): 0.50-0.82]) reduced risk of MetS among females, but only 19% (RR = 0.81 [95% CI: 0.64-1.01]) reduction among males (P-value interaction < 0.05). Stronger inverse associations were also observed for waist circumference and glycated hemoglobin (HbA1c) among females compared with males (-5 cm vs. -2.4 cm and -1.5% vs. -1.0%, respectively). Conclusion: High maternal education in early life was associated with a lower risk of MetS in young adulthood even after accounting for life course risk factors, particularly among females. Results were robust to altered model specifications.
C1 [Huang, Jonathan Yinhao] Agcy Sci Technol & Res, Singapore Inst Clin Sci, 30 Med Dr, Singapore 117609, Singapore.
   [Gariepy, Genevieve] Univ Montreal, Dept Social & Prevent Med, Montreal, PQ, Canada.
   [Gavin, Amelia R.] Univ Washington, Dept Social Work, Seattle, WA 98195 USA.
   [Rowhani-Rahbar, Ali; Enquobahrie, Daniel A.] Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA.
   [Siscovick, David S.] New York Acad Med, New York, NY USA.
C3 Agency for Science Technology & Research (A*STAR); A*STAR - Singapore
   Institute for Clinical Sciences (SICS); Universite de Montreal;
   University of Washington; University of Washington Seattle; University
   of Washington; University of Washington Seattle; New York Academy of
   Medicine
RP Huang, JYH (corresponding author), Agcy Sci Technol & Res, Singapore Inst Clin Sci, 30 Med Dr, Singapore 117609, Singapore.
EM jonathan_huang@sics.a-star.edu.sg
RI Gavin, Amelia/AAX-1229-2021; Huang, Jonathan/J-4139-2019
OI Rowhani-Rahbar, Ali/0000-0002-2705-4485; Huang,
   Jonathan/0000-0002-5901-8403
FU National Institutes of Health (NIH) Reproductive, Perinatal, and
   Pediatric Epidemiology (RPPE) [5T32HD052462-08]; Canadian Institutes for
   Health Research (CIHR) [115214]; NIH [K01HL103174]
FX Portions of this work was supported by National Institutes of Health
   (NIH) Reproductive, Perinatal, and Pediatric Epidemiology (RPPE)
   Training Grant 5T32HD052462-08 and Canadian Institutes for Health
   Research (CIHR) Operating Grant #115214 funded to J.Y.H., though no
   funds were specifically set aside for this article. D.A.E. was funded by
   NIH Career Development Award K01HL103174. G.G. was funded by Canadian
   Institutes for Health Research (CIHR) postdoctoral fellowship.
CR Aguilar M, 2015, JAMA-J AM MED ASSOC, V313, P1973, DOI 10.1001/jama.2015.4260
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NR 54
TC 7
Z9 7
U1 0
U2 9
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1044-3983
EI 1531-5487
J9 EPIDEMIOLOGY
JI Epidemiology
PD NOV
PY 2019
VL 30
SU 2
BP S28
EP S36
DI 10.1097/EDE.0000000000001068
PG 9
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA KF6CV
UT WOS:000509328700005
PM 31569150
DA 2025-06-11
ER

PT J
AU Capuron, L
   Moranis, A
   Combe, N
   Cousson-Gélie, F
   Fuchs, D
   De Smedt-Peyrusse, V
   Barberger-Gateau, P
   Layé, S
AF Capuron, Lucile
   Moranis, Aurelie
   Combe, Nicole
   Cousson-Gelie, Florence
   Fuchs, Dietmar
   De Smedt-Peyrusse, Veronique
   Barberger-Gateau, Pascale
   Laye, Sophie
TI Vitamin E status and quality of life in the elderly: influence of
   inflammatory processes
SO BRITISH JOURNAL OF NUTRITION
LA English
DT Article
DE Vitamin L; Ageing; Inflammation; Quality of life
ID METABOLIC SYNDROME; OXIDATIVE STRESS; SERUM TRYPTOPHAN; ALPHA;
   DEGRADATION; DEPRESSION; CYTOKINES; DEMENTIA; DECLINE; IMMUNE
AB Chronic low-grade inflammation is a characteristics of ageing that may lead to alterations in health status and quality of life. In addition to intrinsic biological factors, recent data suggest that poor nutritional habits may largely contribute to this condition. The present study aimed at assessing mental and physical components of quality of life adn at determining their relationship to vitamin E status, inflammation and tryptophan (TRP) metabolism in the elderly. Sixty-nine elderly subjects recruited from the Three-City cohort study participated in the study Quality of life was assessed using the medical outcomes study thirty-six-item short-form health survey (SF-36). Biological assays included the measurements of plasma vitamin E (alpha-tocopherol), inflammatory marketrs, including IL-6 and C-reactive protein, and TRP metabolism Results showed that participants with poor physical health status, as assessed by the SF-36, exhibited lower circulating concentrations of alpha-tocopherol together with increased cncentrations of inflammatory markers Similarly poor mental health scores on the SF-36 were associated with lower concentrations of alpha-tocophetol, but also with decreased concentrations of TRP These findings indicate that nutritional status, notably as it relates to vitamin E, is associated with immune function and quality of life in the elderly
C1 [Capuron, Lucile; Moranis, Aurelie; De Smedt-Peyrusse, Veronique; Laye, Sophie] Univ Bordeaux 2, INRA 1286, Lab Psychoneuroimmunol Nutr & Genet, CNRS 5226, F-33076 Bordeaux, France.
   [Combe, Nicole] Univ Bordeaux 1, ITERG, F-33405 Talence, France.
   [Cousson-Gelie, Florence] Univ Bordeaux 2, EA 4139, Lab Psychol Hlth & Qual Life, F-33076 Bordeaux, France.
   [Fuchs, Dietmar] Innsbruck Med Univ, Div Biol Chem, Innsbruck, Austria.
   [Barberger-Gateau, Pascale] Univ Bordeaux 2, INSERM, U897, F-33076 Bordeaux, France.
C3 Universite de Bordeaux; INRAE; Universite de Bordeaux; Universite de
   Bordeaux; Medical University of Innsbruck; Universite de Bordeaux;
   Institut National de la Sante et de la Recherche Medicale (Inserm)
RP Capuron, L (corresponding author), Univ Bordeaux 2, INRA 1286, Lab Psychoneuroimmunol Nutr & Genet, CNRS 5226, 146 Rue Leo Saignat, F-33076 Bordeaux, France.
RI Fuchs, Dietmar/AAL-8011-2021; Laye, Sophie/AAX-2501-2020; Cousson-Gelie,
   Florence/K-1225-2017
OI Laye, Sophie/0000-0002-3843-1012; Cousson-Gelie,
   Florence/0000-0002-8195-9170; Capuron, Lucile/0000-0002-2060-5918
CR Alexapoulos GS, 2005, LANCET, V365, P1961, DOI 10.1016/S0140-6736(05)66665-2
   Alperovitch A, 2003, NEUROEPIDEMIOLOGY, V22, P316, DOI 10.1159/000072920
   [Anonymous], 2001, DIETARY REFERENCE IN, DOI DOI 10.1016/S0899-9007(00)00596-7
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   Capuron L, 2004, BIOL PSYCHIAT, V56, P819, DOI 10.1016/j.biopsych.2004.02.009
   Capuron L, 2008, BIOL PSYCHIAT, V64, P896, DOI 10.1016/j.biopsych.2008.05.019
   Deschamps V, 2001, NEUROEPIDEMIOLOGY, V20, P7, DOI 10.1159/000054752
   Franceschi C, 2007, MECH AGEING DEV, V128, P92, DOI 10.1016/j.mad.2006.11.016
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NR 23
TC 44
Z9 48
U1 0
U2 15
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1145
J9 BRIT J NUTR
JI Br. J. Nutr.
PD NOV 28
PY 2009
VL 102
IS 10
BP 1390
EP 1394
DI 10.1017/S0007114509990493
PG 5
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 534TL
UT WOS:000272920100002
PM 19930773
OA Green Accepted, Green Submitted, Bronze
DA 2025-06-11
ER

PT J
AU Vuong, E
   Peer, N
   Chirwa, E
   Mhlongo, S
   Lombard, C
   Hemmings, S
   Kengne, AP
   Abrahams, N
   Seedat, S
AF Vuong, Eileen
   Peer, Nasheeta
   Chirwa, Esnat
   Mhlongo, Shibe
   Lombard, Carl
   Hemmings, Sian
   Kengne, Andre Pascal
   Abrahams, Naeemah
   Seedat, Soraya
TI Prospective Association of Circulating Adipokines with Cardiometabolic
   Risk Profile Among Women: The Rape Impact Cohort Evaluation Study
SO WOMENS HEALTH REPORTS
LA English
DT Article
DE adipokines; cardiometabolic; rape; South Africa
ID PITUITARY-ADRENAL AXIS; METABOLIC SYNDROME; SERUM ADIPONECTIN; SEXUAL
   VIOLENCE; CARDIOVASCULAR-DISEASES; ALCOHOL-CONSUMPTION; PLASMA
   ADIPONECTIN; LEPTIN LEVELS; STRESS; SYMPTOMS
AB Background: Sexual violence is associated with poor cardiometabolic outcomes, yet the etiopathogenic pathways remain unclear. Adipokines may contribute to pathways in the development of cardiometabolic disease (CMD), including in vulnerable populations. Further investigation of adipokines among sexually traumatized individuals may inform cardiometabolic screening. This study aimed to investigate the association between circulating adipokines, metabolic syndrome (MetS), and longitudinal change in MetS components (namely abdominal obesity, blood pressure, lipid profile, and glycemic status) over a 1-year period in a cohort of rape exposed (RE) and rape unexposed (RUE) females.Materials and Methods: Seven hundred seventy-eight RE and 617 RUE black South African women aged 18-40 years were recruited for the Rape Impact Cohort Evaluation study. Nonfasting blood samples were analyzed for cardiometabolic variables and adipokine levels using enzyme-linked immunosorbent assay. Serum adiponectin was measured in both RE and RUE and resistin, leptin, and leptin/adiponectin (L/A) ratio in RE only. Associations between baseline serum adipokines, MetS, and its components were assessed at baseline and follow-up using adjusted linear and logistic regressions.Results: In the RE group, adiponectin, leptin, and L/A ratio were significantly associated with MetS prevalence cross-sectionally (all p <= 0.001). No adipokine marker was related to incident MetS at 12-month follow-up. In the RE group, significant longitudinal associations with high-density lipoprotein cholesterol were shown for adiponectin (beta = 0.146 [0.064], p = 0.022) and leptin (beta = 0.001 [0.002], p = 0.012).Conclusions: Findings suggest that adipokines may have a potential role as biomarkers to identify RE individuals at high risk for CMD.
C1 [Vuong, Eileen; Hemmings, Sian; Seedat, Soraya] Stellenbosch Univ, Dept Psychiat, PTSD Program, South African Res Chairs Initiat SARChI, Stellenbosch, South Africa.
   [Vuong, Eileen; Seedat, Soraya] Stellenbosch Univ, Dept Psychiat, Stellenbosch, South Africa.
   [Peer, Nasheeta; Kengne, Andre Pascal] South African Med Res Council, Noncommunicable Dis Res Unit, Tygerberg, South Africa.
   [Peer, Nasheeta; Kengne, Andre Pascal] Univ Cape Town, Dept Med, Cape Town, South Africa.
   [Chirwa, Esnat; Mhlongo, Shibe; Abrahams, Naeemah] South African Med Res Council, Gender & Hlth Res Unit, Tygerberg, South Africa.
   [Chirwa, Esnat] Univ Witwatersrand, Fac Hlth Sci, Sch Publ Hlth, Johannesburg, South Africa.
   [Lombard, Carl] South African Med Res Council, Biostat Unit, Tygerberg, South Africa.
   [Hemmings, Sian; Seedat, Soraya] Stellenbosch Univ, SAMRC Genom Brain Disorders Unit, Cape Town, South Africa.
   [Abrahams, Naeemah] Univ Cape Town, Fac Hlth Sci, Sch Publ Hlth & Family Med, Cape Town, South Africa.
C3 Stellenbosch University; Stellenbosch University; South African Medical
   Research Council; University of Cape Town; South African Medical
   Research Council; University of Witwatersrand; South African Medical
   Research Council; Stellenbosch University; University of Cape Town
RP Vuong, E (corresponding author), Stellenbosch Univ, Dept Psychiat, POB 241, ZA-8000 Cape Town, South Africa.
EM eileenthomas@sun.ac.za
RI Hemmings, Sian/ABF-9676-2022; Chirwa, Esnat/JJF-2631-2023; Abrahams,
   Naeemah/JAN-9361-2023
OI Thomas, Eileen/0000-0002-5756-7687; Chirwa, Esnat/0000-0003-0471-4978;
   Kengne, Andre Pascal/0000-0002-5183-131X; Abrahams,
   Naeemah/0000-0002-6138-6256
FU South African Research Chair in PTSD - Department of Science and
   Technology [UID64811]; South African Medical Research Council
   [SAMRCRFA-IFSP-01-2013/RAPE COHORT]
FX This research is supported by: (1) The South African Research Chair in
   PTSD (SARChi UID64811) hosted by Stellenbosch University, funded by the
   Department of Science and Technology and administered by the South
   African National Research Foundation and (2) South African Medical
   Research Council in terms of the SAMRC's Flagships Awards Project
   SAMRCRFA-IFSP-01-2013/RAPE COHORT.
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NR 94
TC 0
Z9 0
U1 0
U2 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
EI 2688-4844
J9 WOMENS HEALTH REP
JI Womens Health Reports
PD OCT 1
PY 2022
VL 3
IS 1
BP 820
EP 833
DI 10.1089/whr.2022.0069
PG 14
WC Obstetrics & Gynecology
WE Emerging Sources Citation Index (ESCI)
SC Obstetrics & Gynecology
GA 6R1MR
UT WOS:000892074100001
PM 36340478
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Olorunmoteni, OE
   Gómez-Olivé, FX
   Popoola, BO
   Fatusi, AO
   Scheuermaier, K
AF Olorunmoteni, Oluwatosin Eunice
   Gomez-Olive, F. Xavier
   Popoola, Biliamin O.
   Fatusi, Adesegun Olayiwola
   Scheuermaier, Karine
TI Adolescent sleep health in Africa: a scoping review protocol
SO BMJ OPEN
LA English
DT Review
DE SLEEP MEDICINE; PUBLIC HEALTH; Paediatric neurology; Developmental
   neurology neurodisability; Child adolescent psychiatry; Adolescent
ID RACIAL/ETHNIC DISPARITIES; CARDIOMETABOLIC RISK; DEPRESSION; CHILDREN;
   QUALITY; PATTERN
AB Introduction Problematic sleep is a major threat to health and quality of life among adolescents. Hence, to provide directions for research and interventions, there is a need to examine the literature on adolescent sleep health in Africa. However, available studies on adolescent sleep health in Africa have not been properly mapped. Thus, this scoping review aims to investigate the extent and type of available evidence concerning sleep health among adolescents in Africa and to highlight the relationship of adolescent sleep health with adverse mental health outcomes and cardiometabolic risk factors. The review will further highlight areas of agreement and controversies on adolescent sleep health, and identify evidence gaps that require research attention across the continent.
   Methods and analysis This scoping review will be conducted using Arksey and O'Malley's six-step procedure. Thus, we have prepared this protocol according to the framework for scoping reviews developed by the Joanna Briggs Institute. To identify eligible studies, we will search MEDLINE, Scopus, PsycINFO, AJOL, JSTOR, HINARI and Google Scholar. The review will include all published articles in English, French, Spanish, Portuguese and Italian languages on adolescent sleep health in Africa from the inception of the databases, while relevant information will be extracted from included studies using an adapted data extraction tool. The results will be presented using tables and charts as appropriate.
   Ethics and dissemination The scoping review does not require ethical approval because the publications to be used for the review are publicly available and the study does not involve contact with humans or other animals as research participants. Furthermore, clinical records will not be used for the study. Upon completion, findings from the study will be disseminated through presentations at scientific meetings and publication in a relevant peer-reviewed journal.
   Scoping review registration Open Science Framework (https://osf.io/5sjwq/).
C1 [Olorunmoteni, Oluwatosin Eunice] Obafemi Awolowo Univ, Dept Paediat & Child Hlth, Ife, Nigeria.
   [Olorunmoteni, Oluwatosin Eunice; Scheuermaier, Karine] Univ Witwatersrand, Fac Hlth Sci, Sch Physiol, Johannesburg, South Africa.
   [Gomez-Olive, F. Xavier] Univ Witwatersrand, Fac Hlth Sci, Sch Publ Hlth, Med Res Council,Wits Rural Hlth & Hlth Transit Uni, Johannesburg, South Africa.
   [Popoola, Biliamin O.] Univ Med Sci, Univ Lib, Ondo, Nigeria.
   [Fatusi, Adesegun Olayiwola] Univ Med Sci, Dept Community Med, Ondo, Nigeria.
   [Fatusi, Adesegun Olayiwola] Obafemi Awolowo Univ, Dept Community Hlth, Ife, Nigeria.
C3 Obafemi Awolowo University; University of Witwatersrand; South African
   Medical Research Council; University of Witwatersrand; Obafemi Awolowo
   University
RP Olorunmoteni, OE (corresponding author), Obafemi Awolowo Univ, Dept Paediat & Child Hlth, Ife, Nigeria.; Olorunmoteni, OE (corresponding author), Univ Witwatersrand, Fac Hlth Sci, Sch Physiol, Johannesburg, South Africa.
EM doc_tosino@yahoo.com
RI Popoola, Biliamin/F-2264-2018; Scheuermaier, Karine/AAZ-2056-2021;
   Olorunmoteni, Oluwatosin/IUO-9409-2023; Gómez-Olivé,
   Francesc/AAP-7673-2021
OI Scheuermaier, Karine/0000-0003-3397-543X
FU Consortium for Advanced Research Training in Africa (CARTA); Carnegie
   Corporation of New York [G-19-57145]; Sida [54100113]; Uppsala
   Monitoring Center; Norwegian Agency for Development Cooperation (Norad);
   Wellcome Trust [107768/Z/15/Z]; UK Foreign, Commonwealth amp;
   Development Office; Developing Excellence in Leadership, Training and
   Science in Africa (DELTAS Africa) Programme
FX OEO is supported by the Consortium for Advanced Research Training in
   Africa (CARTA). CARTA is jointly led by the African Population and
   Health Research Center and the University of the Witwatersrand and
   funded by the Carnegie Corporation of New York (grant no: G-19-57145),
   Sida (grant no: 54100113), Uppsala Monitoring Center, Norwegian Agency
   for Development Cooperation (Norad), by the Wellcome Trust (reference
   no. 107768/Z/15/Z) and the UK Foreign, Commonwealth & amp; Development
   Office, with support from the Developing Excellence in Leadership,
   Training and Science in Africa (DELTAS Africa) Programme.
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NR 52
TC 1
Z9 1
U1 0
U2 0
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2044-6055
J9 BMJ OPEN
JI BMJ Open
PD AUG
PY 2023
VL 13
IS 8
AR e067373
DI 10.1136/bmjopen-2022-067373
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA P7EG0
UT WOS:001052262200002
PM 37591652
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Giricz, Z
   Mentzer, RM
   Gottlieb, RA
AF Giricz, Zoltan
   Mentzer, Robert M., Jr.
   Gottlieb, Roberta A.
TI Autophagy, Myocardial Protection, and the Metabolic Syndrome
SO JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
LA English
DT Review
DE autophagy; cardioprotection; metabolic syndrome; myocardial ischemia and
   reperfusion
ID ACTIVATED PROTEIN-KINASE; ISCHEMIA-REPERFUSION INJURY; TERM CALORIC
   RESTRICTION; OXIDATIVE STRESS; DIABETIC HEART; ISCHEMIA/REPERFUSION
   INJURY; MITOCHONDRIAL DYSFUNCTION; ROSIGLITAZONE TREATMENT; DIFFERENTIAL
   ROLES; INSULIN-RESISTANCE
AB Autophagy is a housekeeping process that helps to maintain cellular energy homeostasis and remove damaged organelles. In the heart, autophagy is an adaptive process that is activated in response to stress including acute and chronic ischemia. Given the evidence that autophagy is suppressed in energy-rich conditions, the objective of this review is to examine autophagy and cardioprotection in the setting of the metabolic syndrome. Clinical approaches that involve the induction of cardiac autophagy pharmacologically to enhance the heart's tolerance to ischemia are also discussed.
C1 [Giricz, Zoltan; Mentzer, Robert M., Jr.; Gottlieb, Roberta A.] San Diego State Univ, Donald P Shiley BioSci Ctr, Dept Biol, San Diego, CA 92182 USA.
   [Mentzer, Robert M., Jr.] Wayne State Univ, Sch Med, Dept Physiol, Cardiovasc Res Inst, Detroit, MI 48201 USA.
   [Mentzer, Robert M., Jr.] Wayne State Univ, Sch Med, Dept Surg, Detroit, MI 48201 USA.
C3 California State University System; San Diego State University; Wayne
   State University; Wayne State University
RP Gottlieb, RA (corresponding author), San Diego State Univ, Donald P Shiley BioSci Ctr, Dept Biol, 5500 Campanile Dr, San Diego, CA 92182 USA.
EM robbieg@sciences.sdsu.edu
RI Giricz, Zoltán/B-6990-2008
OI Giricz, Zoltan/0000-0003-2036-8665; Gottlieb,
   Roberta/0000-0002-1432-006X
FU NHLBI NIH HHS [R01 HL034579, R01 HL060590] Funding Source: Medline; NIA
   NIH HHS [R01 AG033283] Funding Source: Medline
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NR 116
TC 40
Z9 42
U1 2
U2 56
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0160-2446
EI 1533-4023
J9 J CARDIOVASC PHARM
JI J. Cardiovasc. Pharmacol.
PD AUG
PY 2012
VL 60
IS 2
BP 125
EP 132
DI 10.1097/FJC.0b013e318256ce10
PG 8
WC Cardiac & Cardiovascular Systems; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Pharmacology & Pharmacy
GA 995KI
UT WOS:000308006500004
PM 22472909
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Fábián, E
   Varga, A
   Picano, E
   Vajo, Z
   Rónaszéki, A
   Csanády, M
AF Fábián, E
   Varga, A
   Picano, E
   Vajo, Z
   Rónaszéki, A
   Csanády, M
TI Effect of simvastatin on endothelial function in cardiac syndrome X
   patients
SO AMERICAN JOURNAL OF CARDIOLOGY
LA English
DT Article
ID DYSFUNCTION; ANGINA
AB Patients with cardiac syndrome X with mild hypercholesterolemia were randomized to placebo (n = 20) or simvastatin 20 mg/day (n = 20). In the simvastatin group, there was a significant (26%; p < 0.0001) decrease in total cholesterol, a 38% (p < 0.0001) decrease in low-density lipoprotein cholesterol levels, and 7% a (p < 0.0001) increase in high-density lipoprotein cholesterol levels, without significant changes in triglyceride levels. Brachial artery flow-mediated dilation increased significantly (52% relative increase, p < 0.0001), and the time to > 1-mm ST-segment depression during stress testing was longer by the end of the study (p < 0.0001). (C)2004 by Excerpta Medica, Inc.
C1 Elisabeth Hosp, Dept Cardiol, H-1037 Budapest, Hungary.
   Univ Sci, Dept Med 2, Szeged, Hungary.
   Ctr Cardiol, Szeged, Hungary.
   Inst Clin Physiol, Pisa, Italy.
RP Elisabeth Hosp, Dept Cardiol, Laborc U 48, H-1037 Budapest, Hungary.
EM dr.fabian.emilia@ihklinika.hu
RI Varga, Agnes/L-6702-2019; Picano, E/G-2261-2014; Vajo,
   Zoltan/J-9016-2019
OI Vajo, Zoltan/0000-0003-1049-1694; Varga, Albert/0000-0002-8879-3927
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NR 11
TC 47
Z9 50
U1 0
U2 1
PU EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
PI BRIDGEWATER
PA 685 ROUTE 202-206 STE 3, BRIDGEWATER, NJ 08807 USA
SN 0002-9149
EI 1879-1913
J9 AM J CARDIOL
JI Am. J. Cardiol.
PD SEP 1
PY 2004
VL 94
IS 5
BP 652
EP 655
DI 10.1016/j.amjcard.2004.05.035
PG 4
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 851RA
UT WOS:000223701400022
PM 15342302
DA 2025-06-11
ER

PT J
AU De Souza, L
   Barros, WD
   De Souza, RM
   Delanogare, E
   Machado, AE
   Braga, SP
   Rosa, GK
   Nardi, GM
   Rafacho, A
   Speretta, GFF
   Moreira, ELG
AF De Souza, Leticia
   Barros, Wellinghton de Medeiros
   De Souza, Raul Marin
   Delanogare, Eslen
   Machado, Adriano Emanuel
   Braga, Sara Pereira
   Rosa, Giovana Karoline
   Nardi, Geisson Marcos
   Rafacho, Alex
   Fina Speretta, Guilherme Fleury
   Gasnhar Moreira, Eduardo Luiz
TI Impact of different fructose concentrations on metabolic and behavioral
   parameters of male and female mice
SO PHYSIOLOGY & BEHAVIOR
LA English
DT Article
DE Sugary beverage; Diet; Metabolic syndrome; Memory; Depression; Anxiety
AB Clinical evidence has shown that a high consumption of sugar-sweetened beverages is a risk factor for developing obesity and metabolic syndrome. There has also been increasing interest in the potential effects of high-fructose intake on behavior. The present study evaluated sex differences in behavioral and metabolic characteristics in response to chronic fructose intake in mice. Swiss mice (3-months-old) had access to tap water or fructose-water solution (at 15% or 30% w/v) ad libitum for nine weeks. After the 8 weeks, the mice were submitted to a battery of behavioral tests. A glucose tolerance test was performed one day after these behavioral tests, and the next day blood was collected for biochemical analysis. At a 15% concentration, fructose-intaking resulted in higher plasma cholesterol levels and glucose intolerance in mice that paralleled with a passive stress-coping behavior in the female mice and lower self-care behavior in the male and the female mice. At a 30% concentration, fructoseintaking resulted in higher body mass gain and higher plasma cholesterol and triglycerides levels in the male and the female mice, whereas glucose intolerance was more pronounced in the male mice. Spatial memory impairments and lower self-care behavior were observed in the male and the female mice, while passive stresscoping behavior was observed only in the female mice. Collectively, high-fructose intake induces metabolic and behavioral alterations in mice, with the males being more susceptible to glucose metabolism dysfunctions and the females to depressive-like endophenotypes.
C1 [Rosa, Giovana Karoline; Rafacho, Alex; Fina Speretta, Guilherme Fleury; Gasnhar Moreira, Eduardo Luiz] Univ Fed Santa Catarina, Dept Ciencias Fisiol, BR-88040900 Florianopolis, SC, Brazil.
   [De Souza, Leticia; Barros, Wellinghton de Medeiros; De Souza, Raul Marin; Delanogare, Eslen; Machado, Adriano Emanuel; Rafacho, Alex; Fina Speretta, Guilherme Fleury; Gasnhar Moreira, Eduardo Luiz] Univ Fed Santa Catarina, Program Posgrad Neurociencias, BR-88040900 Florianopolis, SC, Brazil.
   [Braga, Sara Pereira; Rafacho, Alex; Fina Speretta, Guilherme Fleury; Gasnhar Moreira, Eduardo Luiz] Univ Fed Santa Catarina, Programa Posgrad Multicentr Ciencias Fisiol, BR-88040900 Florianopolis, SC, Brazil.
   [Nardi, Geisson Marcos] Univ Fed Santa Catarina, Programa Posgrad Biol Celular & Desenvolvimento, BR-88040900 Florianopolis, SC, Brazil.
C3 Universidade Federal de Santa Catarina (UFSC); Universidade Federal de
   Santa Catarina (UFSC); Universidade Federal de Santa Catarina (UFSC);
   Universidade Federal de Santa Catarina (UFSC)
RP Moreira, ELG (corresponding author), Univ Fed Santa Catarina, Dept Ciencias Fisiol, BR-88040900 Florianopolis, SC, Brazil.
EM eduardo.luiz@ufsc.br
RI Moreira, Eduardo/N-6420-2014; Barros, Wellinghton/ABD-7550-2021; Nardi,
   Geisson/JNR-2897-2023; Machado, Adriano/KHE-3669-2024; Speretta,
   Guilherme/IQW-2385-2023; Nardi, Geisson Marcos/C-6640-2014; Gasnhar
   Moreira, Eduardo Luiz/S-6205-2016; Rafacho, Alex/O-8609-2016
OI Nardi, Geisson Marcos/0000-0003-0484-8490; de Medeiros Barros,
   Wellinghton/0000-0001-9400-3971; Gasnhar Moreira, Eduardo
   Luiz/0000-0003-2306-2207; Machado, Adriano/0000-0003-2305-1639; Rafacho,
   Alex/0000-0002-8637-6097; Speretta, Guilherme/0000-0003-3474-1264
FU CNPq [Universal 424799/2018-9, 306359/2017-0]; CAPES; FAPESC
FX This research was supported by grants from the Brazilian funding
   agencies: CNPq (Universal 424799/2018-9), CAPES and FAPESC. AR is funded
   by a CNPq research grant [grant number 306359/2017-0].
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NR 46
TC 15
Z9 16
U1 0
U2 15
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0031-9384
J9 PHYSIOL BEHAV
JI Physiol. Behav.
PD JAN 1
PY 2021
VL 228
AR 113187
DI 10.1016/j.physbeh.2020.113187
PG 10
WC Psychology, Biological; Behavioral Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Behavioral Sciences
GA PC2PV
UT WOS:000596850000006
PM 32987042
DA 2025-06-11
ER

PT J
AU O'Brien, AJ
   Abraham, RM
AF O'Brien, Anthony John
   Abraham, Reny Mary
TI Evaluation of metabolic monitoring practices for mental health consumers
   in the Southern District Health Board Region of New Zealand
SO JOURNAL OF PSYCHIATRIC AND MENTAL HEALTH NURSING
LA English
DT Article
DE antipsychotic medication; mental health nurses; metabolic monitoring;
   physical health; primary care
AB Accessible summary
   What is known on this subject?
   The physical health of people with serious mental illness (SMI) is an issue of growing concern in New Zealand and internationally.
   Metabolic syndrome is prevalent among people with severe mental illness and increases the likelihood of developing cardiovascular disease and diabetes.
   No previous international research has investigated rates of metabolic monitoring in specialist mental health services and in primary care.
   What this paper adds to existing knowledge?
   Rates of metabolic monitoring are low in this specialist mental health service and in primary care.
   Primary care nurses are positive in their views of their role in providing care for people with mental illness, and would value further education in this area.
   What are the implications for practice?
   Services need to consider ways in which nurses can be supported to improve rates of metabolic monitoring.
   Guidelines may have a role to play in improved monitoring but need service-level support in order to be effective.
   Introduction
   People with serious mental illness experience significant disparities in their physical health compared with the general population. One indicator of health impairment is metabolic syndrome, which increases the likelihood of developing cardiovascular disease and diabetes. No international studies have reported both primary care and mental health nurses' rates of metabolic monitoring among people with serious mental illness, and no New Zealand studies have investigated rates of metabolic monitoring.
   Aim
   To evaluate metabolic monitoring practices within one of New Zealand's 20 district health board regions.
   Method
   An audit of clinical records in primary care (n = 46) and secondary care (n = 47) settings and a survey of practice nurses were conducted. A survey was sent to 127 practice nurses with a response rate of 19% (n = 24). Data were analysed using descriptive statistics.
   Results
   Rates of metabolic monitoring were low in both services. Survey participants expressed positive views towards physical health monitoring and confidence in relating to mental health consumers. Rates of treatment of metabolic abnormalities were low, and communication between primary and secondary services was limited.
   Conclusion
   Despite existence of guidelines and protocols, metabolic monitoring rates in both primary and secondary health services are low. Incorporating metabolic monitoring systems into service delivery, supported by appropriate tools and resourcing, is essential to achieve better clinical outcomes for people experiencing mental illness.
C1 [O'Brien, Anthony John] Univ Waikato, Private Bag 3105, Hamilton 3240, New Zealand.
   [Abraham, Reny Mary] Southern Dist Hlth Board, Dunedin, New Zealand.
C3 University of Waikato; Dunedin Public Hospital
RP O'Brien, AJ (corresponding author), Univ Waikato, Private Bag 3105, Hamilton 3240, New Zealand.
EM anthony.obrien@waikato.ac.nz
RI O'Brien, Anthony/H-6153-2019
OI O'Brien, Anthony John/0000-0002-2069-8376
FU Health Workforce New Zealand
FX The study was completed with funding support from Health Workforce New
   Zealand.
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NR 66
TC 3
Z9 3
U1 0
U2 9
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1351-0126
EI 1365-2850
J9 J PSYCHIATR MENT HLT
JI J. Psychiatr. Ment. Health Nurs.
PD DEC
PY 2021
VL 28
IS 6
BP 1005
EP 1017
DI 10.1111/jpm.12729
EA JAN 2021
PG 13
WC Nursing; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Psychiatry
GA WX9XN
UT WOS:000610841600001
PM 33382181
DA 2025-06-11
ER

PT J
AU Palmieri, VO
   Grattagliano, I
   Portincasa, P
   Palasciano, G
AF Palmieri, Vincenzo O.
   Grattagliano, Ignazio
   Portincasa, Piero
   Palasciano, Giuseppe
TI Systemic oxidative alterations are associated with visceral adiposity
   and liver steatosis in patients with metabolic syndrome
SO JOURNAL OF NUTRITION
LA English
DT Article
ID NITRIC-OXIDE; CARDIOVASCULAR-DISEASE; ATHEROSCLEROSIS RISK; ANTIOXIDANT
   DEFENSE; HEPATIC-FIBROSIS; N-ACETYLCYSTEINE; S-NITROSOTHIOLS; REDOX
   STATUS; VITAMIN-C; STRESS
AB Although evidence suggests the link between chronic inflammation and oxidative stress as the main mechanism responsible for endothelial dysfunction and cardiovascular complications in patients with metabolic syndrome, little is known about the determining role of each metabolic syndrome component in such alterations. This study investigated the relation between systemic oxidative alterations and metabolic syndrome features in 41 patients. Compared with control subjects, serum vitamin C and alpha-tocopherol concentrations were lower and those of lipid peroxides [thiobarbituric acid reactive substances (TBARs)] were higher in metabolic syndrome patients,(P < 0.001). A linear relation was observed between visceral fat thickness and serum TBARs:cholesterol ratio (r= 0.541, P < 0.001), whereas negative correlations were found between atocopherol and BMI (r= -0.212, P < 0.05) and the grade of liver steatosis (r = -0.263, P < 0.02). Patients with metabolic syndrome and liver steatosis had higher serum hyaluronate (HA) concentrations (P < 0.001). Serum HA was positively correlated with serum alanine amino transferase (r= 0.715, P < 0.001) and the homeostasis monitoring assessment index (r = 0.248, P < 0.03). The presence of metabolic syndrome was predicted from a linear combination of visceral fat and all oxidative variables. In metabolic syndrome patients, serum nitrosothiols and vitamin C concentrations, which were lower (P < 0.001) than in control subjects, were inversely related to the grade of hypertension (r= -0.645, P < 0.001 and r= -0.415, P < 0.007, respectively). In conclusion, metabolic syndrome patients exhibited decreased antioxidant protection and increased lipid peroxidation. Our results indicate a strong association between increased abdominal fat storage, liver steatosis, and systemic oxidative alterations in metabolic syndrome patients and diminished nitrosothiols and vitamin C concentrations as important factors associated with hypertension in these patients.
C1 Univ Bari, Sch Med, Clin Med A Murri, Dept Internal Med & Publ Med, Bari, Italy.
C3 Universita degli Studi di Bari Aldo Moro
RP Grattagliano, I (corresponding author), Univ Bari, Sch Med, Clin Med A Murri, Dept Internal Med & Publ Med, Bari, Italy.
EM i.grattagliano@semeiotica.uniba.it
RI portincasa, piero/J-7245-2018
OI portincasa, piero/0000-0001-5359-1471; palmieri, vincenzo
   ostilio/0000-0002-7649-6028; Palasciano, Giuseppe/0000-0002-0396-488X
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NR 49
TC 153
Z9 168
U1 0
U2 13
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0022-3166
EI 1541-6100
J9 J NUTR
JI J. Nutr.
PD DEC
PY 2006
VL 136
IS 12
BP 3022
EP 3026
DI 10.1093/jn/136.12.3022
PG 5
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 108ZH
UT WOS:000242277200014
PM 17116714
OA Bronze
DA 2025-06-11
ER

PT J
AU Chaves, LO
   Carraro, JCC
   Vidigal, FD
   Bressan, J
AF Chaves, Larissa Oliveira
   Cardoso Carraro, Julia Cristina
   Vidigal, Fernanda de Carvalho
   Bressan, Josefina
TI Higher Waist Circumference Is Related to Lower Plasma Polyunsaturated
   Fatty Acids in Healthy Participants: Metabolic Implications
SO JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION
LA English
DT Article
DE Abdominal obesity; metabolic syndrome; polyunsaturated fatty acids;
   habitual diet; inflammation
ID INSULIN-RESISTANCE; RISK-FACTORS; CARDIOVASCULAR-DISEASE;
   ADIPOSE-TISSUE; URIC-ACID; OBESITY; INFLAMMATION; BLOOD; ASSOCIATION;
   PREVENTION
AB Objective: We evaluated whether the relationship between waist circumference (WC) and cardiometabolic risk is related to usual diet and plasma fatty acid composition. Methods: This cross-sectional study included 226 health professionals from 20 to 59 years old. Anthropometric features, oxidative stress, inflammatory markers, and plasma fatty acid profile were assessed. Dietary intake was evaluated with a semi-quantitative food frequency questionnaire, the quality of dietary habits by Healthy Eating Index, and insulin resistance by homeostasis model assessment-insulin resistance and triglyceride-glucose index. Results: Higher WC was associated with lower concentrations of high-density lipoprotein cholesterol (p = 0.000) and adiponectin (p = 0.000) and higher uric acid levels (p = 0.011). Plasma polyunsaturated fatty acid (PUFA) levels were negatively associated with weight (p = 0.046), systolic blood pressure (p = 0.035), fasting glucose (p = 0.000), triglyceride-glucose index (p = 0.023), and IL-1 beta (p = 0.037). Individuals with elevated WC consumed more calories (p = 0.002), niacin (p = 0.002), and pyridoxine (p = 0.017), but less calcium (p = 0.001), phosphorus (p = 0.016), and vitamin B2 (p = 0.011). In addition, individuals with higher WC denoted lower PUFA concentrations (p = 0.036). Conclusion: The results suggest that participants with higher WC have lower plasma PUFA concentrations and higher levels of saturated fatty acids. This could be related to metabolic and inflammatory changes that could trigger increased risk of metabolic syndrome and cardiovascular disease.
C1 [Chaves, Larissa Oliveira] Univ Fed Vicosa, Dept Nutr & Hlth, Vicosa, MG, Brazil.
   [Cardoso Carraro, Julia Cristina] Univ Fed Ouro Preto, Sch Nutr, Dept Clin & Social Nutr, Ouro Preto, MG, Brazil.
   [Vidigal, Fernanda de Carvalho] Univ Fed Alfenas, Fac Nutr, Alfenas, MG, Brazil.
   [Bressan, Josefina] Univ Fed Vicosa, Dept Nutr & Hlth, Vicosa, MG, Brazil.
C3 Universidade Federal de Vicosa; Universidade Federal de Ouro Preto;
   Universidade Federal de Alfenas; Universidade Federal de Vicosa
RP Bressan, J (corresponding author), Av PH Rolfs S-N,Campus Univ, BR-36571000 Vicosa, MG, Brazil.
EM jbrm@ufv.br
RI de Carvalho Vidigal, Fernanda/ABA-8878-2022; Chaves,
   Larissa/AAB-2281-2020; Bressan, Josefina/A-2598-2009
OI de Carvalho Vidigal, Fernanda/0000-0001-8187-0603; Bressan,
   Josefina/0000-0002-4993-9436
FU CAPES Foundation; Brazilian National Council for Scientific and
   Technological Development (CNPq) [481019/2012-0, 444519/2014-9]; Minas
   Gerais State Research Foundation [FAPEMIG-CDS-APQ01609-10]
FX This research was supported by the CAPES Foundation, Brazilian National
   Council for Scientific and Technological Development (CNPq-CNPq
   processes 481019/2012-0 and 444519/2014-9), and Minas Gerais State
   Research Foundation (FAPEMIG-CDS-APQ01609-10).
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NR 60
TC 3
Z9 3
U1 2
U2 10
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 0731-5724
EI 1541-1087
J9 J AM COLL NUTR
JI J. Am. Coll. Nutr.
PD MAY 19
PY 2019
VL 38
IS 4
BP 342
EP 350
DI 10.1080/07315724.2018.1518171
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA HY9JE
UT WOS:000468455500007
PM 30620245
DA 2025-06-11
ER

PT J
AU Clark, TD
   Reichelt, AC
   Ghosh-Swaby, O
   Simpson, SJ
   Crean, AJ
AF Clark, Thomas D.
   Reichelt, Amy C.
   Ghosh-Swaby, Olivia
   Simpson, Stephen J.
   Crean, Angela J.
TI Nutrition, anxiety and hormones. Why sex differences matter in the link
   between obesity and behavior.
SO PHYSIOLOGY & BEHAVIOR
LA English
DT Review
DE Western diet; Mood disorder; Metabolic-mood syndrome; Sexual dimorphism;
   Behaviour
ID HIGH-FAT DIET; PITUITARY-ADRENAL AXIS; DENDRITIC SPINE DENSITY;
   HIGH-FRUCTOSE DIET; METABOLIC SYNDROME; CHRONIC EXPOSURE; EATING
   BEHAVIOR; CORTISOL-LEVELS; FOOD-INTAKE; STRESS
AB Obesity and mood disorders are two of the most serious health issues of modern times. These health conditions are often linked, with obesity acting both as a cause and consequence of anxiety and depression. Although sex differences in the relationship between obesity and mood disorders are observed in clinical populations, the relative influence of biology versus societal conditioning is unclear. In part, this is because sex effects are rarely examined in the animal models used to derive our understanding of basic biological mechanisms. Due to the perceived confounding nature of hormonal fluctuations in females, rodent studies examining nutritional effects on behavioral responses are typically restricted to males. Yet, hormones play an important role in mediating effects of diet on behavior. In this mini-review, we outline interactions between obesity, hormones and the brain to illustrate the importance of considering sex-specific effects in studies of nutritional effects on behavior. We highlight the need for a more nuanced understanding of how dietary factors influence these relationships, arguing that such knowledge will help improve clinical health outcomes in the management of both obesity and mood disorders.
C1 [Clark, Thomas D.; Simpson, Stephen J.; Crean, Angela J.] Univ Sydney, Charles Perkins Ctr, Sydney, NSW 2006, Australia.
   [Clark, Thomas D.; Simpson, Stephen J.; Crean, Angela J.] Univ Sydney, Sch Life & Environm Sci, Sydney, NSW 2006, Australia.
   [Reichelt, Amy C.] Univ Adelaide, Med Sch, Adelaide, SA 5005, Australia.
   [Reichelt, Amy C.; Ghosh-Swaby, Olivia] Western Univ, Schulich Sch Med & Dent, London, ON, Canada.
C3 University of Sydney; University of Sydney; University of Adelaide;
   Western University (University of Western Ontario)
RP Crean, AJ (corresponding author), Univ Sydney, Charles Perkins Ctr, Sydney, NSW 2006, Australia.; Crean, AJ (corresponding author), Univ Sydney, Sch Life & Environm Sci, Sydney, NSW 2006, Australia.
EM angela.crean@sydney.edu.au
RI Crean, Angela/U-8568-2018; Simpson, Stephen/C-8392-2009
OI Crean, Angela/0000-0003-2605-6435; Simpson, Stephen
   J./0000-0003-0256-7687
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NR 105
TC 12
Z9 14
U1 0
U2 24
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0031-9384
EI 1873-507X
J9 PHYSIOL BEHAV
JI Physiol. Behav.
PD APR 1
PY 2022
VL 247
AR 113713
DI 10.1016/j.physbeh.2022.113713
EA JAN 2022
PG 7
WC Psychology, Biological; Behavioral Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Behavioral Sciences
GA 0J6QR
UT WOS:000780228600001
PM 35066061
DA 2025-06-11
ER

PT J
AU Schmidt, EKA
   Raposo, PJF
   Madsen, KL
   Fenrich, KK
   Kabarchuk, G
   Fouad, K
AF Schmidt, Emma K. A.
   Raposo, Pamela J. F.
   Madsen, Karen L.
   Fenrich, Keith K.
   Kabarchuk, Gillian
   Fouad, Karim
TI What Makes a Successful Donor? Fecal Transplant from Anxious-Like Rats
   Does Not Prevent Spinal Cord Injury-Induced Dysbiosis
SO BIOLOGY-BASEL
LA English
DT Article
DE spinal cord injury; fecal microbiota transplant; inflammation; anxiety;
   rehabilitation
ID CLOSTRIDIUM-DIFFICILE INFECTION; MICROBIOTA TRANSPLANTATION; METABOLIC
   SYNDROME; GUT MICROBIOTA; DOUBLE-BLIND; LACTOBACILLUS; DEPRESSION;
   INFLAMMATION; BEHAVIOR; THERAPY
AB Simple Summary
   Spinal cord injury disrupts the composition of gut bacteria and increases the prevalence of anxiety-like and depressive-like behaviours. We have previously shown that a fecal transplant from uninjured donor rats prevents both injury-induced microbiota changes and the development of anxiety-like behaviour. In the present study, we aimed to determine whether donor selection would influence the efficacy of a fecal transplant after spinal cord injury. We found that a fecal transplant from uninjured donor rats with increased anxiety-like behaviour was not only ineffective in preventing injury-induced microbiota changes, but it also increased intestinal permeability and anxiety-like behaviour of the recipient rats. The results of this study emphasize the importance of optimal donor selection for successful fecal transplant treatment following spinal cord injury.
   Spinal cord injury (SCI) causes gut dysbiosis and an increased prevalence of depression and anxiety. Previous research showed a link between these two consequences of SCI by using a fecal transplant from healthy rats which prevented both SCI-induced microbiota changes and the subsequent development of anxiety-like behaviour. However, whether the physical and mental state of the donor are important factors in the efficacy of FMT therapy after SCI remains unknown. In the present study, rats received a fecal transplant following SCI from uninjured donors with increased baseline levels of anxiety-like behaviour and reduced proportion of Lactobacillus in their stool. This fecal transplant increased intestinal permeability, induced anxiety-like behaviour, and resulted in minor but long-term alterations in the inflammatory state of the recipients compared to vehicle controls. There was no significant effect of the fecal transplant on motor recovery in rehabilitative training, suggesting that anxiety-like behaviour did not affect the motivation to participate in rehabilitative therapy. The results of this study emphasize the importance of considering both the microbiota composition and the mental state of the donor for fecal transplants following spinal cord injury.
C1 [Schmidt, Emma K. A.; Fenrich, Keith K.; Kabarchuk, Gillian; Fouad, Karim] Univ Alberta, Neurosci & Mental Hlth Inst, Edmonton, AB T6G 2R3, Canada.
   [Raposo, Pamela J. F.; Fenrich, Keith K.; Fouad, Karim] Univ Alberta, Fac Rehabil Med, Edmonton, AB T6G 2R3, Canada.
   [Raposo, Pamela J. F.; Fouad, Karim] Univ Alberta, Dept Phys Therapy, Edmonton, AB T6G 2R3, Canada.
   [Madsen, Karen L.] Univ Alberta, Fac Med & Dent, Div Gastroenterol, Edmonton, AB T6G 2R3, Canada.
C3 University of Alberta; University of Alberta; University of Alberta;
   University of Alberta
RP Fouad, K (corresponding author), Univ Alberta, Neurosci & Mental Hlth Inst, Edmonton, AB T6G 2R3, Canada.; Fouad, K (corresponding author), Univ Alberta, Fac Rehabil Med, Edmonton, AB T6G 2R3, Canada.; Fouad, K (corresponding author), Univ Alberta, Dept Phys Therapy, Edmonton, AB T6G 2R3, Canada.
EM ekschmid@ualberta.ca; praposo@ualberta.ca; karen.madsen@ualberta.ca;
   fenrich@ualberta.ca; kabarchu@ualberta.ca; karim.fouad@ualberta.ca
RI Fenrich, Keith/AAG-2780-2020; Madsen, Karen/H-5898-2011
OI Fenrich, Keith/0000-0003-4360-064X; Kabarchuk,
   Gillian/0000-0002-0117-8025; Madsen, Karen/0000-0002-8636-0714; Raposo,
   Pamela/0000-0001-6350-5223; Doolin, Emma/0000-0001-9803-6391
FU Craig Neilsen Foundation [NPRG 542589]
FX This research was funded by the Craig Neilsen Foundation, grant number
   NPRG 542589.
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NR 90
TC 12
Z9 12
U1 0
U2 13
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2079-7737
J9 BIOLOGY-BASEL
JI Biology-Basel
PD APR
PY 2021
VL 10
IS 4
AR 254
DI 10.3390/biology10040254
PG 22
WC Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics
GA RQ9LT
UT WOS:000642733800001
PM 33804928
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Ostojic, P
   Bartolovic, D
AF Ostojic, P.
   Bartolovic, D.
TI Disease activity, obesity, functional disability, and depression in
   patients with rheumatoid arthritis Impact on lipid status,
   glycoregulation, and risk for coronary heart disease
SO ZEITSCHRIFT FUR RHEUMATOLOGIE
LA English
DT Article
DE Risk factors; Glucose metabolism; Lipids; Body mass index; Metabolic
   syndrome
ID INSULIN-RESISTANCE; CARDIOVASCULAR MORTALITY; METABOLIC SYNDROME;
   ADIPOSE-TISSUE; INFLAMMATION; ADIPONECTIN; ATHEROSCLEROSIS; PREVALENCE;
   ANXIETY; PROFILE
AB This study aims to estimate the impact of disease activity, obesity, functional disability, and depression on lipid status, glycoregulation, and risk for coronary heart disease (CHD) in patients with rheumatoid arthritis (RA).
   A total of 36 patients with RA (30 women and 6 men, mean age 54.9 years, mean disease duration 7.9 years) were included in this study. We estimated the impact of age, body mass index, disease activity [assessed by DAS(28) index and C-reactive protein (CRP) value], functional ability (estimated using the HAQ disability index), and depression [assessed using the Beck Depression Inventory (BDI)] on glycoregulation, lipid status, and risk for CHD in our patients. Glycoregulation was assessed by measuring insulin resistance, insulin, and glucose in blood. Lipids tested in blood included total cholesterol, HDL and LDL cholesterol, and triglycerides (TG). The 10-year risk for CHD was estimated using the Framingham risk score.
   Of 36 patients, 11 (30.6 %) fulfilled the criteria for metabolic syndrome (MS). Ten of 11 patients (90.1 %) with MS have a 10-year risk for CHD greater than 10 % compared to only 3 of 25 patients (12 %) without MS (p = 0.0001). Patients with high disease activity had lower HDL values than patients with mild or moderate disease activity (1.4 vs. 1.7 mmol/l, p = 0.04). Significant correlations were observed between CRP level and insulinemia (rho = 0.57, p = 0.003), as well as CRP level and the HOMA index (rho = 0.59, p = 0.002). The body mass index (BMI) correlated significantly with total cholesterol (r = 0.46, p = 0.02), LDL (rho = 0.41, p = 0.04), and TG (rho = 0.65, p < 0.001) in blood. The HAQ-DI did not correlate either with parameters of glycoregulation or lipid status. There was a significant positive correlation between BDI and BMI (rho = 0.60, p < 0.001).
   Active RA is independently associated with decreased HDL cholesterol and increased insulin resistance. Obesity was found to be an independent risk factor for increased total cholesterol, LDL cholesterol, and TG. Depressed patients with RA tend to be overweight or obese and, therefore, have an unfavorable lipid profile.
C1 [Ostojic, P.] Univ Belgrade, Inst Rheumatol, Sch Med, Resavska 69, Belgrade 11000, Serbia.
   [Bartolovic, D.] Clin Ctr Serbia, Dept Med Biochem, Belgrade, Serbia.
C3 University of Belgrade; Clinical Centre of Serbia
RP Ostojic, P (corresponding author), Univ Belgrade, Inst Rheumatol, Sch Med, Resavska 69, Belgrade 11000, Serbia.
EM ostojic@vektor.net
OI Ostojic, Predrag/0000-0002-4035-9515
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NR 41
TC 9
Z9 10
U1 0
U2 11
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0340-1855
EI 1435-1250
J9 Z RHEUMATOL
JI Z. Rheumatol.
PD SEP
PY 2016
VL 75
IS 7
BP 716
EP 722
DI 10.1007/s00393-015-1661-7
PG 7
WC Rheumatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Rheumatology
GA DV4UX
UT WOS:000382921900010
PM 26555552
DA 2025-06-11
ER

PT J
AU Krushas, AE
   Schwartz, JA
AF Krushas, Amber E.
   Schwartz, Joseph A.
TI An Examination of the Components of Toxic Stress in Childhood and
   Biological Markers of Physical Health in Emerging Adulthood
SO JOURNAL OF CHILD & ADOLESCENT TRAUMA
LA English
DT Article
DE Toxic stress; Cardiometabolic risk; Physical health; Childhood trauma
ID GENDER-DIFFERENCES; YOUNG-ADULTS; EXPERIENCES; ALLOSTASIS; ABUSE;
   ADVERSITY; OUTCOMES; IMPACT; RISK; ASSOCIATIONS
AB Experiencing severe and enduring adversity in childhood without the support of adult figures has been linked to an extensive list of physical health outcomes. This finding is closely tied to the concept of toxic stress, which is regularly studied using a combination of sources, including childhood adversity, unmet basic needs, and unmet social needs. Despite these findings, previous work has typically compiled various sources associated with toxic stress into a single construct, limiting existing knowledge on the contribution of each individual source to physical health. To address these concerns, the current study utilizes data from the National Longitudinal Study of Adolescent to Adult Health to examine the association between independent and collective sources of toxic stress in childhood and individual differences in biomarkers tapping cardiometabolic functioning in emerging adulthood. Results indicate a significant association between a composite measure of sources of toxic stress and cardiometabolic risk, with subsequent models examining the independent influence of each source revealing that this association was largely driven by childhood adversity and unmet basic needs, but not unmet social needs. These findings suggest that the individual sources of toxic stress may differentially contribute to physical health outcomes.
C1 [Krushas, Amber E.] Univ Nebraska, Sch Criminol & Criminal Justice, Omaha, NE 68182 USA.
   [Schwartz, Joseph A.] Florida State Univ, Coll Criminol & Criminal Justice, Tallahassee, FL 32312 USA.
   [Schwartz, Joseph A.] King Abdulaziz Univ, Ctr Social & Humanities Res, Jeddah, Saudi Arabia.
C3 University of Nebraska System; State University System of Florida;
   Florida State University; King Abdulaziz University
RP Krushas, AE (corresponding author), Univ Nebraska, Sch Criminol & Criminal Justice, Omaha, NE 68182 USA.
EM akrushas@unomaha.edu
OI Schwartz, Joseph/0000-0001-5777-0573; Krushas, Amber/0000-0002-4859-7518
FU Eunice Kennedy Shriver National Institute of Child Health and Human
   Development [P01-HD31921]
FX This research uses data from National Longitudinal Study of Adolescent
   to Adult Health (Add Health), a program project directed by Kathleen
   Mullan Harris and designed by J. Richard Udry, Peter S. Bearman, and
   Kathleen Mullan Harris at the University of North Carolina at Chapel
   Hill and funded by grant P01-HD31921 from the Eunice Kennedy Shriver
   National Institute of Child Health and Human Development, with
   cooperative funding from 23 other federal agencies and foundations. The
   original research team received approval from the Institutional Review
   Board from the University of North Carolina at Chapel Hill prior to data
   collection.
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NR 74
TC 7
Z9 8
U1 1
U2 3
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1936-1521
EI 1936-153X
J9 J CHILD ADOLES TRAUM
JI J. Child Adolesc. Trauma
PD MAR
PY 2022
VL 15
IS 1
BP 105
EP 119
DI 10.1007/s40653-022-00436-7
EA JAN 2022
PG 15
WC Family Studies; Social Work
WE Emerging Sources Citation Index (ESCI)
SC Family Studies; Social Work
GA YX6HI
UT WOS:000742592400001
PM 35222778
OA Green Published
DA 2025-06-11
ER

PT J
AU Davel, AP
   Lu, Q
   Moss, ME
   Rao, S
   Anwar, IJ
   DuPont, JJ
   Jaffe, IZ
AF Davel, Ana P.
   Lu, Qing
   Moss, M. Elizabeth
   Rao, Sitara
   Anwar, Imran J.
   DuPont, Jennifer J.
   Jaffe, Iris Z.
TI Sex-Specific Mechanisms of Resistance Vessel Endothelial Dysfunction
   Induced by Cardiometabolic Risk Factors
SO JOURNAL OF THE AMERICAN HEART ASSOCIATION
LA English
DT Article
DE aldosterone; endothelial dysfunction; microvascular dysfunction;
   mineralocorticoid receptor; mineralocorticoids; nitric oxide; obesity;
   sex differences
ID MINERALOCORTICOID RECEPTOR ACTIVATION; NITRIC-OXIDE; HYPERPOLARIZING
   FACTOR; METABOLIC SYNDROME; HYDROGEN-PEROXIDE; OXIDATIVE STRESS; WESTERN
   DIET; ARTERIES; DISEASE; OBESITY
AB BackgroundThe incidence of obesity is rising, particularly among women. Microvascular dysfunction is more common with female sex, obesity, and hyperlipidemia and predicts adverse cardiovascular outcomes, but the molecular mechanisms are unclear. Because obesity is associated with mineralocorticoid receptor (MR) activation, we tested the hypothesis that MR in endothelial cells contribute to sex differences in resistance vessel dysfunction in response to cardiometabolic risk factors.
   Methods and ResultsMale and female endothelial cell-specific MR knockout mice and MR-intact littermates were randomized to high-fat-diet-induced obesity or obesity with hyperlipidemia induced by adeno-associated virus-based vector targeting transfer of the mutant stable form (DY mutation) of the human PCSK9 (proprotein convertase subtilisin/kexin type 9) gene and compared with control diet. Female but not male mice were sensitive to obesity-induced endothelial dysfunction, whereas endothelial function was impaired in obese hyperlipidemic males and females. In males, obesity or hyperlipidemia decreased the nitric oxide component of vasodilation without altering superoxide production or endothelial nitric oxide synthase expression or phosphorylation. Decreased nitric oxide content in obese males was overcome by enhanced endothelium-derived hyperpolarization-mediated relaxation along with increased SK3 expression. Conversely, in females, endothelium-derived hyperpolarization was significantly impaired by obesity with lower IK1 expression and by hyperlipidemia with lower IK1 and SK3 expression, loss of H2O2-mediated vasodilation, and increased superoxide production. Endothelial cell-MR deletion prevented endothelial dysfunction induced by risk factors only in females. Rather than restoring endothelium-derived hyperpolarization in females, endothelial cell-MR deletion enhanced nitric oxide and prevented hyperlipidemia-induced oxidative stress.
   ConclusionsThese data reveal distinct mechanisms driving resistance vessel dysfunction in males versus females and suggest that personalized treatments are needed to prevent the progression of vascular disease in the setting of obesity, depending on both the sex and the metabolic profile of each patient.
C1 [Davel, Ana P.; Lu, Qing; Moss, M. Elizabeth; Rao, Sitara; Anwar, Imran J.; DuPont, Jennifer J.; Jaffe, Iris Z.] Tufts Med Ctr, Mol Cardiol Res Inst, 800 Washington St,Box 80, Boston, MA 02111 USA.
   [Davel, Ana P.] Univ Estadual Campinas, Inst Biol, Dept Struct & Funct Biol, Sao Paulo, Brazil.
C3 Tufts Medical Center; Universidade Estadual de Campinas; Universidade de
   Sao Paulo
RP Jaffe, IZ (corresponding author), Tufts Med Ctr, Mol Cardiol Res Inst, 800 Washington St,Box 80, Boston, MA 02111 USA.
EM ijaffe@tuftsmedicalcenter.org
RI Anwar, Imran/GZM-7933-2022; Davel, Ana/L-8801-2013
OI Davel, Ana/0000-0002-9862-4262; Anwar, Imran/0000-0002-5075-4148; Moss,
   M Elizabeth/0000-0002-9761-7263
FU National Institutes of Health [HL095590, HL119290, K12HD092535,
   F30HL137255]; American Heart Association [EIA18290005, 17PRE32910003];
   Sao Paulo Research Foundation [FAPESP 2014/26192-6]; Fundacao de Amparo
   a Pesquisa do Estado de Sao Paulo (FAPESP) [14/26192-6] Funding Source:
   FAPESP; American Heart Association (AHA) [17PRE32910003] Funding Source:
   American Heart Association (AHA)
FX This work was supported by grants from the National Institutes of Health
   (HL095590 and HL119290 to Jaffe, K12HD092535 to Jaffe and DuPont and
   F30HL137255 to Moss), the American Heart Association (EIA18290005 to
   Jaffe and 17PRE32910003 to Moss), and The Sao Paulo Research Foundation
   (FAPESP 2014/26192-6 to Davel).
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NR 59
TC 65
Z9 69
U1 0
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
EI 2047-9980
J9 J AM HEART ASSOC
JI J. Am. Heart Assoc.
PD FEB 20
PY 2018
VL 7
IS 4
AR e007675
DI 10.1161/JAHA.117.007675
PG 19
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA FY2KM
UT WOS:000426644000027
PM 29453308
OA gold, Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Chen, JZ
   Vitetta, L
AF Chen, Jiezhong
   Vitetta, Luis
TI Mitochondria could be a potential key mediator linking the intestinal
   microbiota to depression
SO JOURNAL OF CELLULAR BIOCHEMISTRY
LA English
DT Article
DE gut microbiota; gut permeability; major depressive disorders;
   mitochondria
ID SODIUM-BUTYRATE; ANTIDEPRESSANT DRUGS; NITROSATIVE STRESS; METABOLIC
   SYNDROME; BRAIN; PROBIOTICS; DISORDER; DYSFUNCTION; DYSBIOSIS; NEURONS
AB The intestinal microbiota has been reported to affect depression, a common mental condition with severe health-related consequences. However, what mediates the effect of the intestinal microbiota on depression has not been well elucidated. We summarize the roles of the mitochondria in eliciting beneficial effects on the gut microbiota to ameliorate symptoms of depression. It is well known that mitochondria play a key role in depression. An important pathogenic factor, namely inflammatory response, may adversely impact mitochondrial functionality to maintain cellular homeostasis. Dysfunction of mitochondria not only affects neuronal function but also reduces neuron cell numbers. We posit that the intestinal microbiota could affect neuronal mitochondrial function through short-chain fatty acids such as butyrate. Brain inflammatory processes could also be affected through the modulation of gut permeability and blood lipopolysaccharide levels. Aberrant mitochondria functionality coupled to adverse cellular homeostasis could be a key mediator for the effect of the intestinal microbiota on the progression of depression.
C1 [Chen, Jiezhong; Vitetta, Luis] Medlab Clin Ltd, Sydney, NSW 2015, Australia.
   [Vitetta, Luis] Univ Sydney, Fac Med & Hlth, Sydney, NSW, Australia.
C3 University of Sydney
RP Chen, JZ; Vitetta, L (corresponding author), Medlab Clin Ltd, Sydney, NSW 2015, Australia.
EM Jiezhong_chen@Medlab.co; luis.vitetta@sydney.edu.au
RI Vitetta, Luis/F-4206-2010
OI Chen, Jiezhong/0000-0003-1977-6143; Vitetta, Luis/0000-0002-7490-9298
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NR 90
TC 26
Z9 30
U1 1
U2 36
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0730-2312
EI 1097-4644
J9 J CELL BIOCHEM
JI J. Cell. Biochem.
PD JAN
PY 2020
VL 121
IS 1
BP 17
EP 24
DI 10.1002/jcb.29311
EA AUG 2019
PG 8
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA JQ1VC
UT WOS:000479971500001
PM 31385365
OA Bronze
DA 2025-06-11
ER

PT J
AU Lee, TK
   Wickrama, KAS
   O'Neal, CW
AF Lee, Tae Kyoung
   Wickrama, Kandauda A. S.
   O'Neal, Catherine Walker
TI Early socioeconomic adversity and cardiometabolic risk in young adults:
   mediating roles of risky health lifestyle and depressive symptoms
SO JOURNAL OF BEHAVIORAL MEDICINE
LA English
DT Article
DE Childhood; adolescence adversity; Risky health lifestyle; Depressive
   symptoms; Cardiometabolic risk; Latent class analysis; Path model
ID BODY-MASS INDEX; ADOLESCENCE; CHILDHOOD; DISEASE; STRESS; TRAJECTORIES;
   ASSOCIATION; EXPERIENCES; ENVIRONMENT; TRANSITION
AB The study examined the mediating roles of risky health lifestyle and depressive symptoms in relation to childhood/adolescence adversity and young adult cardiometabolic risk with data from the National Longitudinal Study of Adolescent to Adult Health (n=9421). Four classes of youth emerged from a latent class analysis with varying early adversity patterns: (a) both low disadvantaged SES and stressful experience (54.8%), (b) high disadvantaged SES and low stressful experience (31.0%), (c) low disadvantaged SES and high stressful experience (10.9%), and (d) both high disadvantaged SES and stressful experience (3.3%). Early adversity had multiple direct and indirect effects on CM risk for those experiencing SES-related adversities. Instead, early adversity generated mediational processes between adversity and CM risks through risky health lifestyle and depressive symptoms for those experiencing stressful experience. Implications for intervention when dealing with youths who have experienced multiple forms of early adversity are discussed.
C1 [Lee, Tae Kyoung] Univ Miami, Miller Sch Med, Dept Publ Hlth Sci, 1120 NW 14th St,Suite 1013, Miami, FL 33136 USA.
   [Wickrama, Kandauda A. S.; O'Neal, Catherine Walker] Univ Georgia, Dept Human Dev & Family Sci, Athens, GA 30602 USA.
C3 University of Miami; University System of Georgia; University of Georgia
RP Lee, TK (corresponding author), Univ Miami, Miller Sch Med, Dept Publ Hlth Sci, 1120 NW 14th St,Suite 1013, Miami, FL 33136 USA.
EM txl371@med.miami.edu
RI Lee, Tae/AAE-7907-2021
OI Lee, Tae Kyoung/0000-0001-8712-3182
FU Eunice Kennedy Shriver National Institute of Child Health and Human
   Development [P01-HD31921]
FX This research uses data from Add Health, a program project directed by
   Kathleen Mullan Harris and designed by J. Richard Udry, Peter S.
   Bearman, and Kathleen Mullan Harris at the University of North Carolina
   at Chapel Hill, and funded by Grant P01-HD31921 from the Eunice Kennedy
   Shriver National Institute of Child Health and Human Development, with
   cooperative funding from 23 other federal agencies and foundations.
   Special acknowledgment is due Ronald R. Rindfuss and Barbara Entwisle
   for assistance in the original design. Information on how to obtain the
   Add Health data files is available on the Add Health website
   (http://www.cpc.unc.edu/addhealth).No direct support was received from
   Grant P01-HD31921 for this analysis.
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NR 45
TC 9
Z9 12
U1 0
U2 11
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0160-7715
EI 1573-3521
J9 J BEHAV MED
JI J. Behav. Med.
PD FEB
PY 2019
VL 42
IS 1
BP 150
EP 161
DI 10.1007/s10865-018-9952-5
PG 12
WC Psychology, Clinical
WE Social Science Citation Index (SSCI)
SC Psychology
GA HN7HM
UT WOS:000460359900015
PM 30039261
DA 2025-06-11
ER

PT J
AU Chaudieu, I
   Norton, J
   Ritchie, K
   Birmes, P
   Vaiva, G
   Ancelin, ML
AF Chaudieu, Isabelle
   Norton, Joanna
   Ritchie, Karen
   Birmes, Philippe
   Vaiva, Guillaume
   Ancelin, Marie-Laure
TI Late-Life Health Consequences of Exposure to Trauma in a General Elderly
   Population: The Mediating Role of Reexperiencing Posttraumatic Symptoms
SO JOURNAL OF CLINICAL PSYCHIATRY
LA English
DT Article
ID STRESS-DISORDER SYMPTOMS; CORONARY-HEART-DISEASE; METABOLIC SYNDROME;
   PTSD; EPIDEMIOLOGY; PREVALENCE; ASSOCIATIONS; RELIABILITY; INTERVIEW;
   CHILDREN
AB Objective: A history of trauma is associated with poor mental and physical health, but the specific impact of posttraumatic stress disorder (PTSD) symptoms on physical health using objective indicators of health status has rarely been evaluated in elderly civilians. This study investigates the long-term consequences of a lifetime exposure to trauma on health in a French elderly general population.
   Method: Data from this retrospective study were derived from a longitudinal study (the Enquete de Sante Psychologique-Risques, Incidence et Traitement [ESPRIT]) of community-dwelling participants. Psychiatric health, medical history, and clinical examination (ICD-10 criteria) were assessed in 1,662 subjects (mean [SD] age = 72.5 [5.2] years). Lifetime traumatic exposure, PTSD, and psychiatric diagnoses were obtained using the Watson PTSD Inventory and the Mini-International Neuropsychiatric Interview. The outcome measures used were the Mini-International Neuropsychiatric Interview, Center for Epidemiologic Studies Depression Scale, Mini-Mental State Examination, and measures of physical health.
   Results: We observed an increase in the number and severity of health-related outcomes between groups, with nontraumatized subjects having the lowest risk and those with trauma leading to recurrent reexperiencing of events (nonresilient subjects) having the highest risk. Traumatized persons who did not report reexperiencing symptoms (resilient subjects) showed better current mental health than traumatized subjects who did and nontraumatized subjects. Nonresilient subjects were more likely to have current depressive symptoms (P = .003), current major depression (P < .0001), current anxiety disorder (P = .032), and psychiatric comorbidity (P = .002) than nontraumatized subjects. Resilient subjects differed from nontraumatized subjects in having significantly less current suicidal ideation (P = .054) and psychiatric comorbidity (P = .035). Both groups of traumatized subjects showed a higher rate of cardio-ischemic diseases, notably current angina pectoris (multivariate, adjusted OR = 2.27; 95% CI, 1.31-3.91; and OR = 2.34; 95% CI, 1.22-4.49; for resilient and nonresilient groups, respectively). Traumatized persons, specifically those nonresilient, showed a higher waist-hip ratio, higher triglyceride levels, and a greater frequency of hypertension.
   Conclusions: Our findings suggest that trauma could be associated with cardio-ischemic diseases independently of PTSD symptoms expression. However, the presence of these symptoms appears associated with additional metabolic risk factors. J Clin Psychiatry 2011;72(7):929-935 (C) Copyright 2011 Physicians Postgraduate Press, Inc.
C1 [Chaudieu, Isabelle; Norton, Joanna; Ritchie, Karen; Ancelin, Marie-Laure] Hop La Colombiere, INSERM, U888, F-34093 Montpellier 5, France.
   [Chaudieu, Isabelle; Norton, Joanna; Ritchie, Karen; Ancelin, Marie-Laure] Univ Montpellier I, Montpellier, France.
   [Birmes, Philippe] Univ Toulouse 3, F-31062 Toulouse, France.
   [Birmes, Philippe] Univ Hosp Toulouse, Toulouse, France.
   [Vaiva, Guillaume] Univ Lille N France, CNRS, UMR 8160, Lille, France.
   [Vaiva, Guillaume] Univ Hosp Lille, Lille, France.
   [Ritchie, Karen] Univ London Imperial Coll Sci Technol & Med, Div Neurosci & Mental Hlth, London, England.
C3 Universite de Montpellier; CHU de Montpellier; Institut National de la
   Sante et de la Recherche Medicale (Inserm); Universite de Montpellier;
   Universite de Toulouse; Universite Toulouse III - Paul Sabatier; CHU de
   Toulouse; Universite de Toulouse; Universite Toulouse III - Paul
   Sabatier; Centre National de la Recherche Scientifique (CNRS);
   Universite de Lille; Universite de Lille; CHU Lille; Imperial College
   London
RP Chaudieu, I (corresponding author), Hop La Colombiere, INSERM, U888, Pav 42,39 Ave Charles Flahault,BP 34493, F-34093 Montpellier 5, France.
EM isabelle.chaudieu@inserm.fr
RI Chaudieu, Isabelle/B-8084-2008; VAIVA, Guillaume/J-8983-2015; Ritchie,
   Karen/G-3571-2013; Ancelin, Marie-Laure/L-1198-2019
OI Chaudieu, Isabelle/0000-0003-0587-4842; VAIVA,
   Guillaume/0000-0003-2462-008X; Ritchie, Karen/0000-0002-0688-8982;
   Ancelin, Marie-Laure/0000-0002-1149-4320
FU regional government of Languedoc-Roussillon; Agence Nationale de la
   Recherche [07 LVIE 004]; Novartis, France
FX The Enquete de Sante Psychologique-Risques, Incidence et Traitement
   (ESPRIT) project has been financed by the regional government of
   Languedoc-Roussillon, the Agence Nationale de la Recherche (project 07
   LVIE 004), and an unconditional grant from Novartis, France.
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NR 42
TC 23
Z9 27
U1 0
U2 13
PU PHYSICIANS POSTGRADUATE PRESS
PI MEMPHIS
PA P O BOX 752870, MEMPHIS, TN 38175-2870 USA
SN 0160-6689
EI 1555-2101
J9 J CLIN PSYCHIAT
JI J. Clin. Psychiatry
PD JUL
PY 2011
VL 72
IS 7
BP 929
EP 935
DI 10.4088/JCP.10m06230
PG 7
WC Psychology, Clinical; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA 804UD
UT WOS:000293678600007
PM 21824455
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Sekita, A
   Arima, H
   Ninomiya, T
   Ohara, T
   Doi, Y
   Hirakawa, Y
   Fukuhara, M
   Hata, J
   Yonemoto, K
   Ga, Y
   Kitazono, T
   Kanba, S
   Kiyohara, Y
AF Sekita, Atsuko
   Arima, Hisatomi
   Ninomiya, Toshiharu
   Ohara, Tomoyuki
   Doi, Yasufumi
   Hirakawa, Yoichiro
   Fukuhara, Masayo
   Hata, Jun
   Yonemoto, Koji
   Ga, Yukiko
   Kitazono, Takanari
   Kanba, Shigenobu
   Kiyohara, Yutaka
TI Elevated depressive symptoms in metabolic syndrome in a general
   population of Japanese men: a cross-sectional study
SO BMC PUBLIC HEALTH
LA English
DT Article
DE Depressive symptoms; Metabolic syndrome; Population-based; Japanese
ID LATE-LIFE DEPRESSION; YOUNG-ADULTS; PREVALENCE; HEALTH; ASSOCIATION;
   ANXIETY; COMMUNITY; CORTISOL; DISEASE
AB Background: Uncertainty still surrounds the association between metabolic syndrome (MetS) and depression. We aimed to evaluate the association between MetS and elevated depressive symptoms in a general Japanese population.
   Methods: This is a cross-sectional survey of 3,113 community-dwelling individuals aged 40 years or over. MetS was defined according to the joint interim statement. MetS was diagnosed when a subject had three or more of the following components: 1) central obesity (waist circumference >= 90 cm for men, >= 80 cm in for women); 2) elevated blood pressure (>= 130/85 mmHg or current use of antihypertensive medication); 3) hypertriglyceridemia (>= 1.7 mmol/L); 4) low HDL cholesterol (< 1.0 mmol/L for men, < 1.3 mmol/L for women); and 5) elevated fasting plasma glucose (>= 5.55 mmol/L or current use of antidiabetic medication). Depressive symptoms were assessed using the Center for Epidemiologic Studies Depression Scale (CES-D). The age- and multivariable-adjusted odds ratio (OR) and 95% confidence interval (CI) were estimated using a logistic regression model.
   Results: Elevated depressive symptoms were observed in 4.3% of male and 6.3% of female participants. In men, the age- adjusted prevalence of elevated depressive symptoms was significantly higher in subjects with MetS than in those without (7.1% versus 3.6%, p = 0.04). The prevalence of elevated depressive symptoms rose progressively as the number of MetS components increased (3.5%, 3.6%, 5.8%, and 9.2% in male subjects with 0-1, 2, 3, and >= 4 components, respectively; p = 0.02 for trend). This association remained significant even after adjustment for age, marital status, history of cardiovascular disease, smoking habit, alcohol intake, and regular exercise. In women, on the other hand, there was no clear association between MetS and depressive symptoms.
   Conclusions: MetS was associated with elevated depressive symptoms in a general population of Japanese men.
C1 [Sekita, Atsuko; Arima, Hisatomi; Ohara, Tomoyuki; Hirakawa, Yoichiro; Fukuhara, Masayo; Hata, Jun; Ga, Yukiko; Kiyohara, Yutaka] Kyushu Univ, Grad Sch Med Sci, Dept Environm Med, Higashi Ku, Fukuoka 8128582, Japan.
   [Sekita, Atsuko; Ohara, Tomoyuki; Ga, Yukiko; Kanba, Shigenobu] Kyushu Univ, Grad Sch Med Sci, Dept Neuropsychiat, Higashi Ku, Fukuoka 8128582, Japan.
   [Ninomiya, Toshiharu; Doi, Yasufumi; Kitazono, Takanari] Kyushu Univ, Grad Sch Med Sci, Dept Med & Clin Sci, Higashi Ku, Fukuoka 8128582, Japan.
   [Yonemoto, Koji] Kurume Univ, Ctr Biostat, Kurume, Fukuoka 8300011, Japan.
C3 Kyushu University; Kyushu University; Kyushu University; Kurume
   University
RP Arima, H (corresponding author), Kyushu Univ, Grad Sch Med Sci, Dept Environm Med, Higashi Ku, 3-1-1 Maidashi, Fukuoka 8128582, Japan.
EM harima@envmed.med.kyushu-u.ac.jp
RI Navarrete-Muñoz, Eva/F-1666-2011
FU Ministry of Education, Culture, Sports, Science and Technology of Japan
   [22116010, 22240073, 22590892, 23590797, 23590798, 23500842, 24590797,
   24590796]; Health and Labour Sciences Research Grants of the Ministry of
   Health, Labor and Welfare of Japan [H20-Chouju-004, H22-Junkankitou
   [Seishuu]-Ippan-005, H22-Junkankitou [Seishuu]-Ippan-017,
   H23-Junkankitou [Seishuu]-Ippan-002, H23-Junkankitou
   [Seishuu]-Ippan-005, H23-Ninchisho-Ippan-004]; Grants-in-Aid for
   Scientific Research [25460758, 24590796, 23390164, 23590797, 22700297,
   24590797, 23500842, 23590798, 22116010, 22240073, 25253048] Funding
   Source: KAKEN
FX This study was funded in part by Grants-in-Aid for Scientific Research
   on Innovative Areas (22116010) and for Scientific Research (A)
   (22240073) and (C) (22590892, 23590797, 23590798, 23500842, 24590797,
   and 24590796) from the Ministry of Education, Culture, Sports, Science
   and Technology of Japan and by Health and Labour Sciences Research
   Grants of the Ministry of Health, Labor and Welfare of Japan
   (Comprehensive Research on Aging and Health: H20-Chouju-004;
   Comprehensive Research on Life-Style Related Diseases including
   Cardiovascular Diseases and Diabetes Mellitus: H22-Junkankitou
   [Seishuu]-Ippan-005, H22-Junkankitou [Seishuu]-Ippan-017,
   H23-Junkankitou [Seishuu]-Ippan-002, and H23-Junkankitou
   [Seishuu]-Ippan-005; and Comprehensive Research on Dementia:
   H23-Ninchisho-Ippan-004).
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NR 39
TC 25
Z9 26
U1 1
U2 2
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1471-2458
J9 BMC PUBLIC HEALTH
JI BMC Public Health
PD SEP 18
PY 2013
VL 13
AR 862
DI 10.1186/1471-2458-13-862
PG 7
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA 220XK
UT WOS:000324620400001
PM 24044502
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Battelli, MG
   Bortolotti, M
   Polito, L
   Bolognesi, A
AF Battelli, Maria Giulia
   Bortolotti, Massimo
   Polito, Letizia
   Bolognesi, Andrea
TI The role of xanthine oxidoreductase and uric acid in metabolic syndrome
SO BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
LA English
DT Article
DE Cardiovascular diseases; Metabolic syndrome; Oncogenesis; Oxidative
   stress; Uric acid; Xanthine oxidoreductase
ID REACTIVE SPECIES GENERATION; INSULIN-RESISTANCE; OXIDATIVE STRESS;
   OXIDASE ACTIVITY; ISCHEMIC-STROKE; HEART-FAILURE; RISK; HYPERTENSION;
   FRUCTOSE; CANCER
AB Xanthine oxidoreductase (XOR) could contribute to the pathogenesis of metabolic syndrome through the oxidative stress and the inflammatory response induced by XOR-derived reactive oxygen species and uric acid. Hyperuricemia is strongly linked to hypertension, insulin resistance, obesity and hypertriglyceridemia. The serum level of XOR is correlated to triglyceride/high density lipoprotein cholesterol ratio, fasting glycemia, fasting insulinemia and insulin resistance index. Increased activity of endothelium-linked XOR may promote hypertension. In addition, XOR is implicated in pre-adipocyte differentiation and adipogenesis. XOR and uric acid play a role in cell transformation and proliferation as well as in the progression and metastatic process. Collected evidences confirm the contribution of XOR and uric acid in metabolic syndrome. However, in some circumstances XOR and uric acid may have anti-oxidant protective outcomes. The dual-face role of both XOR and uric acid explains the contradictory results obtained with XOR inhibitors and suggests caution in their therapeutic use.
C1 [Battelli, Maria Giulia; Bortolotti, Massimo; Polito, Letizia; Bolognesi, Andrea] Alma Mater Studiorum Univ Bologna, Dept Expt Diagnost & Specialty Med DIMES, Via San Giacomo 14, I-40126 Bologna, Italy.
C3 University of Bologna
RP Polito, L (corresponding author), Alma Mater Studiorum Univ Bologna, Dept Expt Diagnost & Specialty Med DIMES, Via San Giacomo 14, I-40126 Bologna, Italy.
EM mariagiulia.battelli@unibo.it; massimo.bortolotti2@unibo.it;
   letizia.polito@unibo.it; andrea.bolognesi@unibo.it
RI Bolognesi, Andrea/Q-6526-2017; BORTOLOTTI, MASSIMO/E-1822-2011; Polito,
   Letizia/H-2877-2019; Battelli, Maria Giulia/G-2711-2015
OI BORTOLOTTI, MASSIMO/0000-0001-9030-2237; Bolognesi,
   Andrea/0000-0001-7497-4586; Polito, Letizia/0000-0001-8051-4981;
   Battelli, Maria Giulia/0000-0001-6048-0454
FU Alma Mater Studiorum - University of Bologna; Pallotti Legacies for
   Cancer Research
FX This work was supported by funds for selected research topics from the
   Alma Mater Studiorum - University of Bologna and by the Pallotti
   Legacies for Cancer Research.
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NR 89
TC 142
Z9 150
U1 1
U2 44
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0925-4439
EI 1879-260X
J9 BBA-MOL BASIS DIS
JI Biochim. Biophys. Acta-Mol. Basis Dis.
PD AUG
PY 2018
VL 1864
IS 8
BP 2557
EP 2565
DI 10.1016/j.bbadis.2018.05.003
PG 9
WC Biochemistry & Molecular Biology; Biophysics; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Cell Biology
GA GJ1TB
UT WOS:000435049600005
PM 29733945
OA hybrid, Green Published, Green Accepted
DA 2025-06-11
ER

PT J
AU White, J
   Gray, R
   Jones, M
AF White, J.
   Gray, R.
   Jones, M.
TI The development of the serious mental illness physical Health
   Improvement Profile
SO JOURNAL OF PSYCHIATRIC AND MENTAL HEALTH NURSING
LA English
DT Article
DE bipolar disorder; HIP; metabolic syndrome; physical health;
   schizophrenia; serious mental illness
ID SCHIZOPHRENIA; MORTALITY; COMMUNITY; ILL
AB People with serious mental illness (SMI), such as schizophrenia and bipolar disorder, are more likely to suffer from a range of long-term physical conditions including diabetes and cardiovascular disease. Consequently they will die 10-15 years earlier than the general population. Health services have failed to address this major health inequality because of a lack of consensus about the type and frequency of monitoring people with SMI require and a lack of knowledge and skills in the mental health workforce. We developed the SMI physical Health Improvement Profile to help mental health nurses profile the physical health of the SMI patients they work with and direct them towards the evidence base interventions available to address identified health problems.
C1 [Gray, R.] Univ E Anglia, Norwich NR4 7TJ, Norfolk, England.
   [Jones, M.] Surrey & Borders Partnership NHS Fdn Trust, Surrey, England.
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C3 University of East Anglia; University of Hull
RP White, J (corresponding author), Univ Hull, FHSC, 209 Dearne Bldg,Cottingham Rd, Kingston Upon Hull HU6 7RX, N Humberside, England.
EM Jacqueline.white@hull.ac.uk
RI Jones, Martin/G-7810-2016; Gray, Richard/C-9945-2017; White,
   Jacquie/N-7287-2015
OI Jones, Martin/0000-0002-6463-3574; Gray, Richard/0000-0001-9694-4206;
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NR 21
TC 59
Z9 64
U1 0
U2 13
PU WILEY-BLACKWELL PUBLISHING, INC
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1351-0126
J9 J PSYCHIATR MENT HLT
JI J. Psychiatr. Ment. Health Nurs.
PD JUN
PY 2009
VL 16
IS 5
BP 493
EP 498
DI 10.1111/j.1365-2850.2009.01375.x
PG 6
WC Nursing; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Psychiatry
GA 443FA
UT WOS:000265894400012
PM 19538607
DA 2025-06-11
ER

PT J
AU Bullon, P
   Morillo, JM
   Ramirez-Tortosa, MC
   Quiles, JL
   Newman, HN
   Battino, M
AF Bullon, P.
   Morillo, J. M.
   Ramirez-Tortosa, M. C.
   Quiles, J. L.
   Newman, H. N.
   Battino, M.
TI Metabolic Syndrome and Periodontitis: Is Oxidative Stress a Common Link?
SO JOURNAL OF DENTAL RESEARCH
LA English
DT Review
DE metabolic syndrome; oxidative stress; periodontitis; hypertension;
   dyslipidemia; insulin resistance
ID GINGIVAL CREVICULAR FLUID; GLYCATION END-PRODUCTS;
   LOW-DENSITY-LIPOPROTEIN; C-REACTIVE PROTEIN; SUPEROXIDE-DISMUTASE
   ACTIVITY; TOTAL ANTIOXIDANT CAPACITY; INDUCED INSULIN-RESISTANCE; TYPE-2
   DIABETES-MELLITUS; CORONARY-HEART-DISEASE; NECROSIS-FACTOR-ALPHA
AB A review of pathological mechanisms that can explain the relationship between periodontitis and cardiovascular disease (CVD) is necessary to improve the management of both conditions. Metabolic syndrome is a combination of obesity, hypertension, impaired glucose tolerance or diabetes, hyperinsulinemia, and dyslipidemia. All these have been examined in recent years in terms of their relationship to periodontitis. Reviewed data indicate an association between some of them (body mass index, high-density lipoprotein-cholesterol [HDL-C], triglycerides, high blood pressure, among others) and periodontitis. Oxidative stress may act as a potential common link to explain relationships between each component of metabolic syndrome and periodontitis. Both conditions show increased serum levels of products derived from oxidative damage, with a pro-inflammatory state likely influencing each other bidirectionally. Adipocytokines might modulate the oxidant/anti-oxidant balance in this relationship.
C1 [Battino, M.] Univ Politecn Marche, Fac Med, Inst Biochem, Via Ranieri 65, I-60100 Ancona, Italy.
   [Bullon, P.; Morillo, J. M.] Univ Seville, Sch Dent, Dept Periodontol, Seville, Spain.
   [Ramirez-Tortosa, M. C.] Univ Granada, Dept Biochem & Mol Biol 2, Inst Nutr & Food Technol, E-18071 Granada, Spain.
   [Quiles, J. L.] Univ Granada, Dept Physiol, Inst Nutr & Food Technol, E-18071 Granada, Spain.
   [Newman, H. N.] UCL, London WC1E 6BT, England.
C3 Marche Polytechnic University; University of Sevilla; University of
   Granada; University of Granada; University of London; University College
   London
RP Battino, M (corresponding author), Univ Politecn Marche, Fac Med, Inst Biochem, Via Ranieri 65, I-60100 Ancona, Italy.
EM m.a.battino@univpm.it
RI Bullon, Pedro/E-6319-2010; Battino, Maurizio/E-6103-2012; Quiles, Jose
   L./C-6911-2013
OI Bullon, Pedro/0000-0003-4873-4196; Battino,
   Maurizio/0000-0002-7250-1782; Quiles, Jose L./0000-0002-9048-9086
FU Universita Politecnica delle Marche, Italy; Grupo de investigacion
   CTS113 Junta de Andalucia, Spain
FX Funding for this research was from Universita Politecnica delle Marche,
   Italy, and Grupo de investigacion CTS113 Junta de Andalucia, Spain.
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NR 166
TC 180
Z9 202
U1 0
U2 34
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0022-0345
EI 1544-0591
J9 J DENT RES
JI J. Dent. Res.
PD JUN
PY 2009
VL 88
IS 6
BP 503
EP 518
DI 10.1177/0022034509337479
PG 16
WC Dentistry, Oral Surgery & Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dentistry, Oral Surgery & Medicine
GA 468FD
UT WOS:000267801300003
PM 19587154
OA Green Published
DA 2025-06-11
ER

PT J
AU Hornero-Ramirez, H
   Aubin, A
   Michalski, MC
   Vinoy, S
   Caussy, C
   Nazare, JA
AF Hornero-Ramirez, Hugo
   Aubin, Adrien
   Michalski, Marie-Caroline
   Vinoy, Sophie
   Caussy, Cyrielle
   Nazare, Julie-Anne
TI Multifunctional dietary interventions, low-grade inflammation and
   cardiometabolic profile: a scoping review
SO FRONTIERS IN IMMUNOLOGY
LA English
DT Review
DE bioactive compound; food synergy; oxidative stress; Mediterranean;
   Nordic; portfolio; cardiometabolic profile; human
ID CHOLESTEROL-LOWERING FOODS; RANDOMIZED CONTROLLED-TRIAL; CARDIOVASCULAR
   RISK-FACTORS; STOP HYPERTENSION DASH; HEALTHY NORDIC DIET; HIGH-FAT
   MEAL; METABOLIC SYNDROME; BLOOD-PRESSURE; OBESE SUBJECTS; SERUM-LIPIDS
AB Background Growing evidence highlights the significant impact of diet to modify low-grade inflammation closely linked to cardiometabolic profile. Multifunctionnal diets, combining several compounds have been shown to beneficially impact metabolic parameters.Objective This study synthesizes the knowledge on the impact of RCTs combining dietary multifunctional compounds on low-grade inflammation in humans. We investigate whether the effects of dietary multifunctional interventions on inflammatory markers were parallel to alterations of cardiometabolic parameters.Methodology We considered both the integrated dietary interventions (ID, i.e. global diets such as Mediterranean, Nordic horizontal ellipsis ) and the dietary interventions based on selected bioactive mix (BM) compounds, in healthy individuals and those at cardiometabolic risk. Out of 221 screened publications, we selected 27 studies: 11 for BM (polyphenols and/or omega-3 fatty acids and/or antioxidants and/or dietary fiber) and 16 for ID (Mediterranean, paleo, Nordic, Dietary Approaches to Stop Hypertension (DASH) diet horizontal ellipsis ).Results ID studies reflected significant improvements in inflammatory markers (CRP, IL-6, IL-10, IL-1b), concomitantly with beneficial changes in metabolic parameters. In BM studies, pronounced effects on low-grade inflammatory markers were observed, while improvements in metabolic parameters were not consistent. Both types of studies suggested a favorable impact on oxidative stress, a factor closely linked to the inflammatory profile.Conclusion Our findings showed that multifunctional RCT diets have differential role in managing low-grade inflammation and cardiometabolic health, with a large heterogeneity in explored inflammatory markers. Further research is imperative to elucidate the link between low-grade inflammation and other cardiometabolic risk factors, such as intestinal inflammation or postprandial inflammatory dynamics, aiming to attain a comprehensive understanding of the mechanisms involved in these processes. These future investigations not only have the potential to deepen our insights into the connections among these elements but also pave the way for significant advancements in the prevention and management of conditions related to the cardiovascular and metabolic systems.
C1 [Hornero-Ramirez, Hugo; Michalski, Marie-Caroline; Caussy, Cyrielle; Nazare, Julie-Anne] Claude Bernard Lyon1 Univ, Univ Lyon, Ctr Hosp Lyon Sud, Ctr Rech Nutr Humaine Rhone Alpes,CarMeN Lab,INSER, Pierre Benite, France.
   [Aubin, Adrien; Caussy, Cyrielle] Hop Lyon Sud, Dept Endocrinol Diabet & Nutr, Hosp Civils Lyon, Pierre Benite, France.
   [Vinoy, Sophie] Paris Saclay Tech Ctr, Nutr Res, Mondelez Int R&D, F-91400 Saclay, France.
C3 Institut National de la Sante et de la Recherche Medicale (Inserm);
   Universite Claude Bernard Lyon 1; CHU Lyon; CHU Lyon; Mondelez
   International
RP Nazare, JA (corresponding author), Claude Bernard Lyon1 Univ, Univ Lyon, Ctr Hosp Lyon Sud, Ctr Rech Nutr Humaine Rhone Alpes,CarMeN Lab,INSER, Pierre Benite, France.
EM julie-anne.nazare@univ-lyon1.fr
RI Aubin, Adrien/NES-6373-2025
OI Caussy, Cyrielle/0000-0001-8089-2907
FU Agence Nationale de la Recherche, ANR PRCE; French Ministry of Higher
   Education and Research
FX The author(s) declare financial support was received for the research,
   authorship, and/or publication of this article. This research was funded
   by the Agence Nationale de la Recherche, ANR PRCE (SINFONI project
   "Synergistic INnovative Functional fOod concepts to Neutralize
   Inflammation for cardiometabolic risk prevention", coordinated by JA
   Nazare. Hugo Hornero was supported by a PhD grant from the French
   Ministry of Higher Education and Research.
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NR 60
TC 5
Z9 5
U1 0
U2 4
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-3224
J9 FRONT IMMUNOL
JI Front. Immunol.
PD FEB 27
PY 2024
VL 15
AR 1304686
DI 10.3389/fimmu.2024.1304686
PG 16
WC Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology
GA KJ6S2
UT WOS:001179637300001
PM 38476230
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Panagiotopoulos, A
   Fragoulis, GE
AF Panagiotopoulos, Alexandros
   Fragoulis, George E.
TI Comorbidities in Psoriatic Arthritis: A Narrative Review
SO CLINICAL THERAPEUTICS
LA English
DT Review
DE mental health disorders; Epidemiologic; pathogenetic
ID ADVERSE CARDIOVASCULAR EVENTS; C-REACTIVE PROTEIN; QUALITY-OF-LIFE;
   RHEUMATOID-ARTHRITIS; RISK-FACTORS; DEPRESSIVE SYMPTOMS;
   DIABETES-MELLITUS; EULAR RECOMMENDATIONS; METABOLIC SYNDROME;
   INFLAMMATION
AB Purpose: Psoriatic arthritis (PsA) is a common type of inflammatory arthritis. Patients with PsA present with certain extra-articular manifestations and comorbidities (often collectively called psoriatic disease ). The purpose of the present review was to highlight the main comorbidities in the setting of PsA. Methods: A narrative review was performed using data from articles found in a search of PubMed comorbidities . Findings: Cardiovascular disease (CVD), as well as metabolic and mental health disorders, are the most common comorbidities in patients with PsA. In most cases, underlying inflammation seems to be involved in the increased risk for CVD in PsA, while a bidirectional comorbidities in clinical trials and in clinical practice.
C1 [Panagiotopoulos, Alexandros; Fragoulis, George E.] Univ Athens, Dept Propedeut Internal Med 1, Joint Acad Rheumatol Program, Athens, Greece.
   [Fragoulis, George E.] Univ Glasgow, Inst Infect Immun & Inflammat, Glasgow, Scotland.
C3 National & Kapodistrian University of Athens; University of Glasgow
RP Panagiotopoulos, A (corresponding author), Univ Athens, Dept Propedeut Internal Med 1, Joint Acad Rheumatol Program, Athens, Greece.
RI Panagiotopoulos, Alexandros/MTC-0422-2025
OI Fragoulis, George/0000-0003-4932-7023; Panagiotopoulos,
   Alexandros/0000-0003-3612-9394
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NR 120
TC 19
Z9 19
U1 0
U2 1
PU ELSEVIER
PI BRIDGEWATER
PA 685 ROUTE 202-206, BRIDGEWATER, NJ 08807 USA
SN 0149-2918
EI 1879-114X
J9 CLIN THER
JI Clin. Ther.
PD FEB
PY 2023
VL 45
IS 2
BP 177
EP 189
DI 10.1016/j.clinthera.2023.01.006
EA MAR 2023
PG 13
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA J3VR2
UT WOS:001008929000001
PM 36737317
DA 2025-06-11
ER

PT J
AU Tarbiah, NI
   Khalifa, FK
   Alkhattabi, NA
   Banjabi, AA
   Ghazali, RF
   Alzahri, RY
   Almerabi, NA
   Mansour, AA
AF Tarbiah, Nesrin I.
   Khalifa, Fares K.
   Alkhattabi, Nuha A.
   Banjabi, Abeer A.
   Ghazali, Reem F.
   Alzahri, Reem Y.
   Almerabi, Norah Abdu
   Mansour, Ahd A.
TI Synergistic effect of ferulic acid and caffeic acid on metabolic
   syndrome and immune response in rats
SO ANNALS OF CLINICAL AND ANALYTICAL MEDICINE
LA English
DT Article
DE High-Fat Diet; Metabolic Syndrome; Immune Response; Oxidative Stress;
   Caffeic Acid; Ferulic Acid; Phenolic Acids
ID ANTIOXIDANT
AB Aim: The aim of the study is to evaluate the synergistic modulatory effects of ferulic acid (FA) in combination with caffeic acid (CA) on the immune response and metabolic syndrome in male rats fed high-fat diets (HFD).Material and Methods: Forty-five adult male albino rats (Sprague-Dawley) were divided into five groups: G1, controls fed basal fat diet (BFD); G2, high-fat modified diet containing 20% fat (HFD); G3, rats fed HFD and received FA (150 mg/day) orally; G4, rats fed HFD supplemented with CA (0.8 g/ 100 g diet), and G5, Rats fed HFD and received both FA (150 mg/day) and CA (0.8 g/ 100 g diet).Results: Serum concentrations of TG, TC, LDL-c, glucose, insulin, oxidative stress biomarkers, and proinflammatory cytokines were elevated in rats fed a high -fat diet compared with the BFD group. Significant adjustments were observed after the administration of FA and CA. The maximum improvement was viewed in rats administered with CA in combination with FA.Discussion: FA and CA significantly counteracted the pronounced oxidative stress effect of HFD by the inhibition of lipid peroxidation, restoration of antioxidant status, and metabolic syndrome biomarker levels. In conclusion, these findings indicate the synergistic protective effect of FA and CA on risk factors that can lead to metabolic syndrome and immune response imbalance during HFD-associated oxidative stress in rats.
C1 [Tarbiah, Nesrin I.; Khalifa, Fares K.; Alkhattabi, Nuha A.; Banjabi, Abeer A.] King Abdulaziz Univ, Fac Sci, Dept Biochem, Jeddah, Saudi Arabia.
   [Khalifa, Fares K.] Ain Shams Univ, Fac Women Arts Sci & Educ, Dept Biochem & Nutr, Cairo, Egypt.
   [Ghazali, Reem F.] King Abdulaziz Univ, Fac Med, Dept Clin Biochem, Jeddah, Saudi Arabia.
   [Alzahri, Reem Y.] Univ Jeddah, Coll Sci, Dept Biol, Jeddah, Saudi Arabia.
   [Almerabi, Norah Abdu] Ibn Sina Natl Coll Med Studies, Fac Pharm, Dept Pharm D, Jeddah, Saudi Arabia.
   [Mansour, Ahd A.] Fakeeh Coll Med Sci, Dept Med Lab Sci, MLS program, Jeddah, Saudi Arabia.
C3 King Abdulaziz University; Egyptian Knowledge Bank (EKB); Ain Shams
   University; King Abdulaziz University; University of Jeddah; Ibn Sina
   National College for Medical Studies; Fakeeh College for Medical
   Sciences
RP Tarbiah, NI (corresponding author), King Abdulaziz Univ, Fac Sci, Dept Biochem, Jeddah, Saudi Arabia.
EM ntarabah@kau.edu.sa
RI Khalifa, Fares/U-3731-2018; Banjabi, Abeer/ABB-9406-2020; Tarbiah,
   Nesrin/GLQ-6199-2022; Mansour, Ahd/KBA-1256-2024
OI Mansour, Ahd/0000-0003-3729-4770; Tarbiah, Nesrin/0000-0002-8706-2663
CR Chowdhury FI, 2022, SAUDI PHARM J, V30, P1454, DOI 10.1016/j.jsps.2022.07.006
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NR 25
TC 0
Z9 0
U1 1
U2 5
PU BAYRAKOL MEDICAL PUBLISHER
PI ANKARA
PA EMRAH MAHALLESI, GULGUN CADDESI, NO 62-58, KECIOREN, ANKARA, 06010,
   Turkiye
EI 2667-663X
J9 ANN CLIN ANAL MED
JI Ann. Clin. Anal. Med.
PD JAN
PY 2024
VL 15
IS 1
BP 42
EP 46
DI 10.4328/ACAM.22005
PG 5
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA EV3T5
UT WOS:001141675700005
OA gold
DA 2025-06-11
ER

PT J
AU Suttajit, S
   Pilakanta, S
AF Suttajit, Sirijit
   Pilakanta, Sutrak
TI Predictors of quality of life among individuals with schizophrenia
SO NEUROPSYCHIATRIC DISEASE AND TREATMENT
LA English
DT Article
DE adverse events; depression; negative symptoms; positive symptoms; social
   support
ID CLINICAL ANTIPSYCHOTIC TRIALS; NEGATIVE SYNDROME SCALE; SOCIAL SUPPORT;
   SOCIODEMOGRAPHIC FACTORS; METABOLIC SYNDROME; OUT-PATIENTS; DEPRESSION;
   OLDER; SYMPTOMATOLOGY; RELIABILITY
AB Purpose: The study reported here aimed to evaluate both biological and psychosocial factors as predictors for quality of life as well as to examine the associations between the factors and quality of life in individuals with schizophrenia.
   Methods: Eighty individuals with schizophrenia were recruited to the study. The Thai version of the World Health Organization Quality of Life-BREF was utilized to measure the quality of life. The five Marder subscales of the Positive and Negative Syndrome Scale were applied. Other tools for measurement included the Calgary Depression Scale for Schizophrenia and six social support deficits (SSDs). Pearson/Spearman correlation coefficients and the independent t-test were used for the statistical analysis to determine the associations of variables and the overall quality of life and the four domain scores. A multiple linear regression analysis of the overall quality of life and four domain scores was applied to determine their predictors.
   Results: The Positive and Negative Syndrome Scale total score, positive symptoms, negative symptoms, disorganized thought, and anxiety/depression showed a significant correlation with the overall quality of life and most of the four domain scores. Depression, SSDs, and adverse drug events showed a significant correlation with a poorer overall quality of life. The multiple linear regression model revealed that negative symptoms, depression, and seeing a relative less often than once per week were predictors for the overall quality of life (adjusted R-2=0.472). Negative symptoms were also found to be the main factors predicting a decrease in the four domains of quality of life - physical health, psychological, social relationships, and environment.
   Conclusion: Negative symptoms, depression, and poor contact with relatives were the foremost predictors of poor quality of life in individuals with schizophrenia. Positive symptoms, negative symptoms, disorganized thought, anxiety/depression, SSDs, and adverse events were also found to be correlated with quality of life.
C1 [Suttajit, Sirijit; Pilakanta, Sutrak] Chiang Mai Univ, Fac Med, Dept Psychiat, Chiang Mai 50200, Thailand.
C3 Chiang Mai University
RP Suttajit, S (corresponding author), Chiang Mai Univ, Fac Med, Dept Psychiat, 110 Intavaroros Rd, Chiang Mai 50200, Thailand.
EM sirijits@gmail.com
OI Suttajit, Sirijit/0000-0002-6408-769X
FU Faculty of Medicine, Chiang Mai University
FX This study was supported by a grant from the Faculty of Medicine, Chiang
   Mai University.
CR [Anonymous], COCHRANE DATABASE SY
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NR 43
TC 24
Z9 30
U1 0
U2 9
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
EI 1178-2021
J9 NEUROPSYCH DIS TREAT
JI Neuropsychiatr. Dis. Treat.
PY 2015
VL 11
DI 10.2147/NDT.S81024
PG 9
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA CJ0PG
UT WOS:000355178400002
PM 26064055
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Schneider, JG
   Finck, BN
   Ren, J
   Standley, KN
   Takagi, M
   Maclean, KH
   Bernal-Mizrachi, C
   Muslin, AJ
   Kastan, MB
   Semenkovich, CF
AF Schneider, Jochen G.
   Finck, Brian N.
   Ren, Jie
   Standley, Kara N.
   Takagi, Masatoshi
   Maclean, Kirsteen H.
   Bernal-Mizrachi, Carlos
   Muslin, Anthony J.
   Kastan, Michael B.
   Semenkovich, Clay F.
TI ATM-dependent suppression of stress signaling reduces vascular disease
   in metabolic syndrome
SO CELL METABOLISM
LA English
DT Article
ID N-TERMINAL KINASE; FOAM CELL-FORMATION; INSULIN-RESISTANCE;
   ATAXIA-TELANGIECTASIA; LIPOPROTEIN-LIPASE; DIABETES-MELLITUS; OXIDATIVE
   STRESS; IONIZING-RADIATION; INDUCED APOPTOSIS; DEFICIENT MICE
AB Metabolic syndrome is associated with insulin resistance and atherosclerosis. Here, we show that deficiency of one or two alleles of ATM, the protein mutated in the cancer-prone disease ataxia telangiectasia, worsens features of the metabolic syndrome, increases insulin resistance, and accelerates atherosclerosis in apoE(-/-) mice. Transplantation with ATM(-/-) as compared to ATM(+/+) bone marrow increased vascular disease. Jun N-terminal kinase (JNK) activity was increased in ATM-deficient cells. Treatment of ATM(+/+)apoE(-/-) mice with low-dose chloroquine, an ATM activator, decreased atherosclerosis. In an ATM-dependent manner, chloroquine decreased macrophage JNK activity, decreased macrophage lipoprotein lipase activity (a proatherogenic consequence of JNK activation), decreased blood pressure, and improved glucose tolerance. Chloroquine also improved metabolic abnormalities in ob/ob and db/db mice. These results suggest that ATMdependent stress pathways mediate susceptibility to the metabolic syndrome and that chloroquine or related agents promoting ATM activity could modulate insulin resistance and decrease vascular disease.
C1 Washington Univ, Sch Med, Dept Med, St Louis, MO 63110 USA.
   Washington Univ, Sch Med, Dept Cell Biol & Physiol, St Louis, MO 63110 USA.
   St Jude Childrens Hosp, Dept Hematol Oncol, Memphis, TN 38105 USA.
C3 Washington University (WUSTL); Washington University (WUSTL); St Jude
   Children's Research Hospital
RP Semenkovich, CF (corresponding author), Washington Univ, Sch Med, Dept Med, St Louis, MO 63110 USA.
EM csemenko@wustl.edu
RI ren, jun/KHG-7717-2024; Takagi, Masatoshi/F-3713-2011; Segura-Aguilar,
   Juan/H-8839-2013
OI Bernal-Mizrachi, Carlos/0000-0002-8991-7522; Semenkovich,
   Clay/0000-0003-1163-1871; Finck, Brian/0000-0001-5411-3674
FU NCI NIH HHS [CA21765, CA71387] Funding Source: Medline; NHLBI NIH HHS
   [P50 HL083762, HL57278] Funding Source: Medline; NIA NIH HHS [AG20091]
   Funding Source: Medline; NIDDK NIH HHS [DK56341, DK20579, P30 DK056341]
   Funding Source: Medline; NIEHS NIH HHS [ES05777] Funding Source: Medline
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NR 56
TC 201
Z9 230
U1 0
U2 10
PU CELL PRESS
PI CAMBRIDGE
PA 50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA
SN 1550-4131
EI 1932-7420
J9 CELL METAB
JI Cell Metab.
PD NOV
PY 2006
VL 4
IS 5
BP 377
EP 389
DI 10.1016/j.cmet.2006.10.002
PG 13
WC Cell Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Endocrinology & Metabolism
GA 103JU
UT WOS:000241882300008
PM 17084711
OA Bronze
DA 2025-06-11
ER

PT J
AU Girona, J
   Manzanares, JM
   Marimón, F
   Cabré, A
   Heras, M
   Guardiola, M
   Ribalta, J
   Masana, L
AF Girona, Josefa
   Manzanares, Josep M.
   Marimon, Francesc
   Cabre, Anna
   Heras, Mercedes
   Guardiola, Montse
   Ribalta, Josep
   Masana, Lluis
TI Oxidized to non-oxidized lipoprotein ratios are associated with
   arteriosclerosis and the metabolic syndrome in diabetic patients
SO NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
LA English
DT Article
DE lipid peroxidation; atherosclerosis; metabolic syndrome; paraoxonase 1;
   polymorphism; type 2 diabetes
ID LOW-DENSITY-LIPOPROTEIN; CORONARY-HEART-DISEASE; SERUM PARAOXONASE
   ACTIVITY; OXIDATIVE STRESS; ARTERY-DISEASE; LDL OXIDATION; PON1 GENE;
   RISK; AUTOANTIBODIES; POLYMORPHISM
AB Background and aim: Type 2 diabetic patients have a greater prevalence of the metabolic syndrome, oxidative stress and accelerated atherosclerosis, compared to non-diabetics. We examined the association between biomarkers of lipid peroxidation and the presence of atherosclerosis and the metabolic syndrome in diabetic patients.
   Methods and results: We studied oxidized LDL (OxLDL), OxLDL/LDL, OxLDL/HDL, lipoperoxides, autoantibodies against OxLDL (OxLDL-Ab), diene formation of LDL (tag phase), vitamin E, vitamin E/cholesterol and PON1 polymorphisms (-108C > T, 55T > A, and 192A > G) in 166 non-smoking type 2 diabetic patients, 119 fulfilling the criteria for the metabolic syndrome, 73 with atherosclerosis and 93 without atherosclerosis. Patients with macrovascular disease had higher values of OxLDL/LDL (11%; P = 0.016), OxLDL/HDL (18%; P = 0.024) and OxLDL-Ab (12%; P = 0.046). OxLDL/LDL and OxLDL/HDL were correlated with the number of components of the metabolic syndrome (P < 0.001). PON1 polymorphisms were not associated to LDL oxidation markers, only PON1 (-108TT) was weakly associated with higher OxLDL-Ab concentrations (22%; P = 0.040) in patients with atherosclerosis.
C1 [Girona, Josefa; Manzanares, Josep M.; Marimon, Francesc; Cabre, Anna; Heras, Mercedes; Guardiola, Montse; Ribalta, Josep; Masana, Lluis] St Joan Univ Hosp Reus, Dept Internal Med, IRCIS,Res Unit Lipids & Atherosclerosis, Fac Med & Hlth Sci, Reus, Spain.
RP Girona, J (corresponding author), Fac Med & Ciencies Salut, Unitat Rec Lipids & Arteriosclerosi, C St Llorenc 21, Reus 43201, Spain.
EM josefa.girona@urv.cat
RI , Montse/HJY-5534-2023; Ribalta, Josep/AAD-4859-2020; MASANA,
   LUIS/M-7002-2019; Girona, Josefa/U-3489-2018; Manzanares-Errazu,
   Jose-Maria/G-6504-2015
OI Girona, Josefa/0000-0002-6267-8779; Ribalta, Josep/0000-0002-8879-4719;
   Guardiola, Montse/0000-0002-9696-7384; Masana, Luis/0000-0002-0789-4954;
   Manzanares-Errazu, Jose-Maria/0000-0001-9901-0433
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NR 41
TC 46
Z9 50
U1 3
U2 6
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0939-4753
EI 1590-3729
J9 NUTR METAB CARDIOVAS
JI Nutr. Metab. Carbiovasc. Dis.
PD JUN
PY 2008
VL 18
IS 5
BP 380
EP 387
DI 10.1016/j.numecd.2007.04.002
PG 8
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism; Nutrition
   & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism;
   Nutrition & Dietetics
GA 317VO
UT WOS:000257048600007
PM 17904830
DA 2025-06-11
ER

PT J
AU Cho, YM
AF Cho, Youngmin
TI The effects of nonstandard work schedules on workers' health: A
   mediating role of work-to-family conflict
SO INTERNATIONAL JOURNAL OF SOCIAL WELFARE
LA English
DT Article
DE nonstandard work schedules; health; work-to-family conflict; General
   Social Survey; USA
ID SHIFT-WORK; MENTAL-HEALTH; METABOLIC SYNDROME; DIABETES-MELLITUS;
   OUTCOMES; MOTHERS; TIME; PRESENTEEISM; ANTECEDENTS; PERSPECTIVE
AB This study examined the relationship between nonstandard work schedules, work-to-family conflict, and health status in the USA adult population. Based on pooled data from the 2006, 2010, and 2014 General Social Survey (N=4,108), this study found that nonstandard work schedules were associated with poor self-rated health and increased days of poor physical and mental health. Also, results from the causal mediation analysis indicated that the relationship between nonstandard work schedules and health status was significantly mediated by work-to-family conflict. These findings suggest that work-to-family conflict may be an important mechanism through which nonstandard work schedules affect workers' health status.
C1 [Cho, Youngmin] Case Western Reserve Univ, Jack Joseph & Morton Mandel Sch Appl Social Sci, 11235 Bellflower Rd, Cleveland, OH 44106 USA.
C3 University System of Ohio; Case Western Reserve University
RP Cho, YM (corresponding author), Case Western Reserve Univ, Jack Joseph & Morton Mandel Sch Appl Social Sci, 11235 Bellflower Rd, Cleveland, OH 44106 USA.
EM yxc468@case.edu
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NR 70
TC 17
Z9 27
U1 1
U2 27
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1369-6866
EI 1468-2397
J9 INT J SOC WELF
JI Int. J. Soc. Welf.
PD JAN
PY 2018
VL 27
IS 1
BP 74
EP 87
DI 10.1111/ijsw.12269
PG 14
WC Social Work
WE Social Science Citation Index (SSCI)
SC Social Work
GA FQ1MW
UT WOS:000418123100008
OA Bronze
DA 2025-06-11
ER

PT J
AU Kudinova, AY
   Kulak, MJ
   Daniels, TE
   Lewis-de los Angeles, WL
   de la Monte, S
   Mathis, KJ
   Beck, QM
   Laumann, LE
   Tyrka, AR
AF Kudinova, Anastacia Y.
   Kulak, Meghan J.
   Daniels, Teresa E.
   Lewis-de los Angeles, William
   de la Monte, Suzanne
   Mathis, Karen Jennings
   Beck, Quincy M.
   Laumann, Laura E.
   Tyrka, Audrey R.
TI Increased plasminogen activator inhibitor-1 (PAI-1) and its associations
   with metabolic risk in healthy young adults with early life stress
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE PAI-1; Plasminogen activator inhibitor 1; Early life stress; Childhood
   adversity; Cardiometabolic risk; Metabolic syndrome
ID 4G/5G POLYMORPHISM; CHILDHOOD TRAUMA; ADIPOSE-TISSUE; DISEASE RISK;
   MANAGEMENT; FIBRINOLYSIS; PREVALENCE; ABUSE; LINKS
AB Objectives: We aimed to characterize the interplay between early life stress (ELS), metabolic syndrome (MetS), and plasminogen activator inhibitor-1 (PAI-1), a major inhibitor of the fibrinolytic system implicated in cardiometabolic diseases. We also examined the understudied intersection of ELS, physical activity and PAI-1. Methods: Healthy young adults ages 18 -40 ( N =200; 68% female) were recruited from the community. Participants with ELS ( N =118) experienced childhood maltreatment, and the majority ( n =92) also experienced childhood parental loss. Control participants ( N =82) had no history of childhood maltreatment or parental loss. Participants had no current cardiometabolic or thrombotic conditions. Fasting plasma samples were assessed for markers of metabolic risk and total PAI-1 using the Bio-Plex Pro Human Diabetes Panel (Bio-Rad Laboratories). A composite metabolic risk z-score (MetS risk) was computed from the mean standardized z-scores of waist-toheight ratio, systolic and diastolic blood pressure, triglycerides, total cholesterol, LDL and HLD cholesterol, fasting plasma glucose, and hemoglobin A1c. Results: We found that a history of ELS was linked to both higher PAI-1 levels and a higher MetS risk score. ELS was associated with a higher MetS Z-score in adulthood via increased circulating PAI-1 levels (Average Causal Mediation Effect [ACME] = 0.07, p = 0.036). ELS was also linked to increased PAI-1 levels via greater MetS zscores (ACME = 0.02, p < 0.001). There was a significant interaction effect of ELS and exercise on PAI-1 levels (p = 0.03), such that engaging in higher levels of daily exercise was linked to lower PAI-1 levels in individuals with ELS. Conclusion: Healthy young adults with ELS have elevated PAI-1 levels and metabolic risk scores. Among individuals with ELS, exercise is linked to lower PAI-1 levels, suggesting a potential direction for early intervention.
C1 [Kudinova, Anastacia Y.; Lewis-de los Angeles, William] Hasbro Childrens Hosp, Dept Pediat, East Providence, RI USA.
   [Kudinova, Anastacia Y.; Lewis-de los Angeles, William] Bradley Hosp, East Providence, RI USA.
   [Kudinova, Anastacia Y.; Kulak, Meghan J.; Lewis-de los Angeles, William] Brown Univ, Warren Alpert Med Sch, Providence, RI 02912 USA.
   [Kulak, Meghan J.; Daniels, Teresa E.; Mathis, Karen Jennings; Beck, Quincy M.; Laumann, Laura E.; Tyrka, Audrey R.] Brown Univ, Initiat Stress Trauma & Resilience STAR, Dept Psychiat & Human Behav, Warren Alpert Med Sch, Providence, RI USA.
   [Daniels, Teresa E.; Beck, Quincy M.; Laumann, Laura E.; Tyrka, Audrey R.] Butler Hosp, Mood Disorders Res Program, Providence, RI USA.
   [Daniels, Teresa E.; Beck, Quincy M.; Laumann, Laura E.; Tyrka, Audrey R.] Butler Hosp, Lab Clin & Translat Neurosci, Providence, RI USA.
   [de la Monte, Suzanne] Brown Univ, Dept Pathol, Alpert Med Sch, Providence, RI USA.
   [de la Monte, Suzanne] Providence VA Med Ctr, Providence, RI USA.
   [de la Monte, Suzanne] Rhode Isl Hosp, Providence, RI USA.
   [Mathis, Karen Jennings] Miriam Hosp, Ctr Behav & Prevent Med, Providence, RI USA.
C3 Hasbro Children's Hospital; Brown University; Brown University; Butler
   Hospital Rhode Island; Butler Hospital Rhode Island; Brown University;
   US Department of Veterans Affairs; Veterans Health Administration (VHA);
   Providence VA Medical Center; Lifespan Health Rhode Island; Rhode Island
   Hospital; Lifespan Health Rhode Island; Miriam Hospital
RP Kulak, MJ (corresponding author), Brown Univ, Warren Alpert Med Sch, Providence, RI 02912 USA.
EM meghan_kulak@brown.edu
RI Jennings Mathis, Karen/AAK-4766-2020; Tyrka, Audrey/L-2504-2014;
   Laumann, Laura/MGB-5703-2025
OI Tyrka, Audrey/0000-0003-4653-1651; Laumann, Laura/0000-0002-1188-3991
FU National Institute of Mental Health (NIMH) [MH101076, R01MH101107,
   P20GM139767, R01HD086487]; National Institute of Child and Human
   Development (NICHD) [T32HD101392]; Hasbro/Bradley Pilot Clinical
   Research Award from Lifespan; NIMH [K23MH122587]; National Institute of
   General Medical Sciences (NIGMS) [P20GM139767, P20GM139743]
FX This research was supported by National Institute of Mental Health
   (NIMH) grants R01MH101107 (ART) Dr. Tyrka's time was additionally
   supported by P20GM139767 and R01HD086487 (ART). Dr. Meghan Kulak and Dr.
   Teresa Daniels received support from National Institute of Mental Health
   (NIMH) grant MH101076 (ART), and Dr. Daniels also received support from
   the National Institute of Child and Human Development (NICHD) grant
   T32HD101392 (ART). Dr. William Lewis-de los Angeles and Dr. Audrey Tyrka
   also received support from the Hasbro/Bradley Pilot Clinical Research
   Award from Lifespan. Dr. Kudinova's time was supported by the NIMH
   K23MH122587 and the National Institute of General Medical Sciences
   (NIGMS) P20GM139743. Dr. Karen Jennings Mathis was supported by the
   NIGMS P20GM139767 (LRS).
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NR 53
TC 1
Z9 1
U1 0
U2 0
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
EI 1873-3360
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD AUG
PY 2024
VL 166
AR 107071
DI 10.1016/j.psyneuen.2024.107071
EA MAY 2024
PG 8
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA TT3H0
UT WOS:001243465000001
PM 38754340
DA 2025-06-11
ER

PT J
AU Formichi, C
   Cantara, S
   Ciuoli, C
   Neri, O
   Chiofalo, F
   Selmi, F
   Tirone, A
   Colasanto, G
   Di Cosmo, L
   Vuolo, G
   Pacini, F
AF Formichi, Caterina
   Cantara, Silvia
   Ciuoli, Cristina
   Neri, Ornella
   Chiofalo, Francesco
   Selmi, Federico
   Tirone, Andrea
   Colasanto, Giuseppina
   Di Cosmo, Leonardo
   Vuolo, Giuseppe
   Pacini, Furio
TI Weight Loss Associated with Bariatric Surgery Does Not Restore Short
   Telomere Length of Severe Obese Patients After 1 Year
SO OBESITY SURGERY
LA English
DT Article
DE Telomere length; Obesity; Bariatric surgery; Metabolic syndrome
ID INSULIN-RESISTANCE; OXIDATIVE STRESS; ADIPOSE-TISSUE; DIET; MEN
AB Background Telomere shortening is physiologically associated with ageing but it may be influenced by oxidative stress and chronic inflammation, linked to obesity. Thus, obesity might represent an additional cause of telomere attrition. We aim to study relative telomere length (RTL) in obese subjects with and without metabolic syndrome and to assess the effect of weight loss induced by bariatric surgery.
   Methods We evaluated RTL in 107 obese subjects (62 with metabolic syndrome and 45 without metabolic syndrome), compared to 130 age-matched non-obese subjects. We also measured RTL in a subgroup of 93 obese patients prior to and 3, 6, 9 and 12 months after surgery.
   Results RTL of obese subjects was significantly shorter (p<0.0001) than non-obese subjects but without differences between patients with and without metabolic syndrome (p=0.19). RTL was significantly shorter than baseline at 3, 6, 9 and 12 months after bariatric surgery.
   Conclusions These results confirm that obese subjects have shorter telomeres compared to non-obese subjects, but RTL is not influenced by the presence of metabolic syndrome. RTL shows an additional attrition during the immediate postoperative period, probably due to a catabolic state.
C1 [Formichi, Caterina; Cantara, Silvia; Ciuoli, Cristina; Neri, Ornella; Chiofalo, Francesco; Selmi, Federico; Pacini, Furio] Univ Siena, Dept Med Surg & Neurol Sci, I-53100 Siena, Italy.
   [Tirone, Andrea; Colasanto, Giuseppina; Di Cosmo, Leonardo; Vuolo, Giuseppe] Univ Siena, Dept Surg Sci, Bariatr Surg Unit, I-53100 Siena, Italy.
C3 University of Siena; University of Siena
RP Ciuoli, C (corresponding author), Univ Siena, Dept Med Surg & Neurol Sci, Viale Mario Bracci 16, I-53100 Siena, Italy.
EM catefo@libero.it; silviacantara@hotmail.com;
   c.ciuoli@ao-siena.toscana.it; orni@hotmail.it; fra_chiofalo@libero.it;
   f.selmi@live.it; andrea.tirone@alice.it; mykene@libero.it;
   dicosmo@unisi.it; g.vuolo@ao-siena.toscana.it; pacini8@unisi.it
RI Cantara, Silvia/J-8808-2016; Formichi, Caterina/HGA-5525-2022
OI Cantara, Silvia/0000-0002-5741-295X; FORMICHI,
   CATERINA/0000-0001-7703-8216
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NR 30
TC 25
Z9 27
U1 0
U2 4
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0960-8923
EI 1708-0428
J9 OBES SURG
JI Obes. Surg.
PD DEC
PY 2014
VL 24
IS 12
BP 2089
EP 2093
DI 10.1007/s11695-014-1300-4
PG 5
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA AX2NH
UT WOS:000346780400013
PM 24913239
DA 2025-06-11
ER

PT J
AU Yarmohammadi, F
   Rahbardar, MG
   Hosseinzadeh, H
AF Yarmohammadi, Fatemeh
   Rahbardar, Mahboobeh Ghasemzadeh
   Hosseinzadeh, Hossein
TI Effect of eggplant (Solanum melongena) on the metabolic
   syndrome: A review
SO IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
LA English
DT Review
DE Antihypertensive; Antihyperlipidemic; Aubergine; Diabetes; Eggplant;
   Metabolic syndrome; Solanum melongena
ID BLOOD-PRESSURE; OXIDATIVE STRESS; ETHANOL EXTRACT; OBESITY; PLANT;
   ACETYLCHOLINE; EPIDEMIOLOGY; DELPHINIDIN; CONSTITUENT; INHIBITORS
AB Metabolic syndrome (MetS), also known as syndrome X, is a significant risk factor for cardiovascular disease incidence and mortality. Increasing age, obesity, physical inactivity, smoking, and positive family history are the risk factors associated with MetS, which increases the risk of diabetes, cardiovascular disease, hypertension, hyperlipidemia, and obesity. Chemical compounds in the treatment of metabolic complications are associated with a lack of efficacy and severe side effects. Numerous studies have described the importance of herbs and natural products to treat human diseases. Therefore, nowadays, herbs-based diets and herbal medicines are recommended for the management of various diseases. The protective effects of several herbs have been reported against MetS such as rosemary, avocado, and silymarin. Eggplant (Solanum melongena) is a rich source of phenolic and alkaloid compounds. It possesses various pharmacological effects, including, anti-oxidant, antidiabetic, antihypertensive, and antihyperlipidemic, which has been supported by numerous investigations. In this review, we evaluated the effects of eggplant on MetS and its complications comprising diabetes, high blood pressure, hyperlipidemia, and obesity.
   According to these studies, eggplant can control diabetes through the anti-oxidative properties and inhibition of ?-amylase and ?-glucosidase activity. Also, eggplant has exerted an antihypertensive effect via ACE inhibitory activity. Eggplant may have shown protective effects on hyperlipidemia and obesity via the induction of lipoprotein lipase activity and the reduction of pancreatic lipase activity. Eggplant can be useful in the treatment of MetS and its complications.
C1 [Yarmohammadi, Fatemeh] Mashhad Univ Med Sci, Student Res Comm, Mashhad, Razavi Khorasan, Iran.
   [Yarmohammadi, Fatemeh; Rahbardar, Mahboobeh Ghasemzadeh; Hosseinzadeh, Hossein] Mashhad Univ Med Sci, Sch Pharm, Dept Pharmacodynam & Toxicol, Mashhad, Razavi Khorasan, Iran.
   [Hosseinzadeh, Hossein] Mashhad Univ Med Sci, Pharmaceut Res Ctr, Pharmaceut Technol Inst, Mashhad, Razavi Khorasan, Iran.
C3 Mashhad University of Medical Sciences; Mashhad University of Medical
   Sciences; Mashhad University of Medical Sciences
RP Hosseinzadeh, H (corresponding author), Mashhad Univ Med Sci, Pharmaceut Res Ctr, Pharmaceut Technol Inst, Mashhad, Razavi Khorasan, Iran.
EM hosseinzadehh@mums.ac.ir
RI Ghasemzadeh Rahbardar, Mahboobeh/V-4452-2019; Yarmohammadi,
   Fatemeh/GQQ-1975-2022; Hosseinzadeh, Hossein/F-3013-2010
OI Ghasemzadeh Rahbardar, Mahboobeh/0000-0002-5491-572X; Yarmohammadi,
   Fatemeh/0000-0002-0552-8766
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NR 97
TC 32
Z9 32
U1 2
U2 22
PU MASHHAD UNIV MED SCIENCES
PI MASHHAD
PA VICE-CHANCELLOR FOR RES CTR OFF IJBMS, DANESHGAH ST, PO BOX 9138813944 -
   445, MASHHAD, 00000, IRAN
SN 2008-3866
EI 2008-3874
J9 IRAN J BASIC MED SCI
JI Iran. J. Basic Med. Sci.
PD APR
PY 2021
VL 24
IS 4
BP 420
EP 427
DI 10.22038/ijbms.2021.50276.11452
PG 8
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA RC5IP
UT WOS:000632835100001
PM 34094022
DA 2025-06-11
ER

PT J
AU Musso, G
   Gambino, R
   De Michieli, F
   Biroli, G
   Premoli, A
   Pagano, G
   Bo, S
   Durazzo, M
   Cassader, M
AF Musso, Giovanni
   Gambino, Roberto
   De Michieli, Franco
   Biroli, Giampaolo
   Premoli, Alberto
   Pagano, Gianfranco
   Bo, Simona
   Durazzo, Marilena
   Cassader, Maurizio
TI Nitrosative stress predicts the presence and severity of nonalcoholic
   fatty liver at different stages of the development of insulin resistance
   and metabolic syndrome: possible role of vitamin A intake
SO AMERICAN JOURNAL OF CLINICAL NUTRITION
LA English
DT Article
DE retinoid; microsomal triacylglycerol transfer protein; MTP polymorphism;
   nitrotyrosine; adipokines
ID HOMEOSTASIS MODEL ASSESSMENT; TRANSFER PROTEIN GENE; X-RECEPTOR-ALPHA;
   ALANINE AMINOTRANSFERASE; LIPID-PEROXIDATION; RETINOIC-ACID;
   BETA-CAROTENE; STEATOHEPATITIS; DISEASE; GLUCOSE
AB Background: Although nonalcoholic fatty liver disease (NAFLD) is associated with the metabolic syndrome, the mechanisms responsible for the development of NAFLD at different stages of the development of insulin resistance are unknown. Diet, adipokines, and nitrosative stress have been linked to both NAFLD and insulin resistance.
   Objective: We aimed to identify the factors that are specifically associated with NAFLD at different stages in the development of insulin resistance and the metabolic syndrome.
   Design: Circulating concentrations of adipokines (ie, tumor necrosis factor-a, adiponectin, resistin, leptin, and interleukin-6), markers of nitrosative stress (nitrotyrosine), dietary habits, and MTP -493G/T polymorphism were cross-sectionally related to the presence and severity of insulin resistance (homeostasis model assessment index for insulin resistance: >= 2), the metabolic syndrome, and fatty liver in 64 nonobese nondiabetic patients with NAFLD (33 insulin-sensitive and 31 insulin-resistant subjects) and 74 control subjects without liver disease who were matched for sex, BMI, homeostasis model assessment index for insulin resistance status, and the various features of the metabolic syndrome.
   Results: Persons with NAFLD had greater systemic nitrosative stress and a lower intake of vitamins A and E than did control subjects, but the 2 groups did not differ significantly in any other features. Nitrotyrosine and adiponectin concentrations and vitamin A intakes independently predicted alanine aminotransferase concentrations in NAFLD patients and liver histology in a subgroup of 29 subjects with biopsy-proven nonalcoholic steatohepatitis.
   Conclusions: Oxidative stress is operating in NAFLD and nonalcoholic steatohepatitis, even in the absence of insulin resistance, the metabolic syndrome, and hypoadiponectinemia, which aggravate liver histology at more severe stages of metabolic disease. The possible pathogenetic role of reduced vitamin A intake in NAFLD warrants further investigation.
C1 Gradenigo Hosp, Dept Emergency Med, I-10124 Turin, Italy.
   Univ Turin, Inst Internal Med, Turin, Italy.
C3 Humanitas Hospital Gradenigo; University of Turin
RP Musso, G (corresponding author), Gradenigo Hosp, Dept Emergency Med, Corso Regina Margherita 8, I-10124 Turin, Italy.
EM giovanni_musso@yahoo.it
RI Bo, Simona/AAC-1110-2019; Musso, Giovanni/AAB-7884-2022; GAMBINO,
   Roberto/AAC-7517-2022
OI DURAZZO, Marilena/0000-0003-2450-5911; Bo, Simona/0000-0001-6862-8628
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U2 8
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0002-9165
EI 1938-3207
J9 AM J CLIN NUTR
JI Am. J. Clin. Nutr.
PD SEP
PY 2007
VL 86
IS 3
BP 661
EP 671
DI 10.1093/ajcn/86.3.661
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 210WC
UT WOS:000249485300020
PM 17823431
OA Bronze
DA 2025-06-11
ER

PT J
AU Guerdjikova, AI
   McElroy, SL
   Kotwal, R
   Keck, PE
AF Guerdjikova, A. I.
   McElroy, S. L.
   Kotwal, R.
   Keck, P. E., Jr.
TI Comparison of obese men and women with binge eating disorder seeking
   weight management
SO EATING AND WEIGHT DISORDERS-STUDIES ON ANOREXIA BULIMIA AND OBESITY
LA English
DT Article
DE gender; obesity; mood disorders; binge eating; metabolic; weight loss
ID FEMALE ADOLESCENTS; GENDER-DIFFERENCES; HELP-SEEKING; COMMUNITY;
   POPULATION; DEPRESSION; PROGRAM; BULIMIA; PREVALENCE; OVERWEIGHT
AB This study examined whether obese males with binge eating disorder (BED) seeking weight loss treatment differed significantly from obese females with BED seeking weight loss treatment in developmental variables, Weight loss history, current and lifetime prevalence of psychiatric disorders, and metabolic abnormalities. METHODS: Psychiatric (using the Structural Clinical Interview for DSM-IV), medical, and laboratory assessments of 44 obese males with BED were compared with assessments from 44 age- and race-matched obese females with BED seeking weight loss treatment. RESULTS: High rates of mood disorders, anxiety disorders, and metabolic syndrome were observed in the population as a whole. Obese males with BED had attempted significantly fewer diets, medications and supplements for weight loss before seeking weight loss treatment. The two genders did not differ significantly in any other of the examined variables. CONCLUSIONS: Our results suggest that while obese men and women With BED who present for weight management are very similar, males had fewer previous attempts at weight loss, possibly related to their less pronounced body dissatisfaction or fewer help-seeking behaviors as compared to females. Our results also support findings of substantial comorbidity among obesity, BED, mood and anxiety disorders, and metabolic syndrome in weight loss seeking Populations, in men as well as women. (Eating Weight Disord. 12: e19-e23, 2007). (C) 2007, Editrice Kurtis
C1 [Guerdjikova, A. I.; McElroy, S. L.; Kotwal, R.; Keck, P. E., Jr.] Univ Cincinnati, Coll Med, Dept Psychiat, Psychopharmacol Res Program, Cincinnati, OH 45267 USA.
C3 University System of Ohio; University of Cincinnati
RP Guerdjikova, AI (corresponding author), Univ Cincinnati, Coll Med, Dept Psychiat, Psychopharmacol Res Program, 231 Albert Sabin Way,ML 559, Cincinnati, OH 45267 USA.
CR [Anonymous], sion Scale for Schizophrenia; CGI-S, Clinical Global Impres
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NR 42
TC 35
Z9 42
U1 1
U2 10
PU EDITRICE KURTIS S R L
PI MILAN
PA VIA LUIGI ZOJA 30, 20153 MILAN, ITALY
SN 1124-4909
J9 EAT WEIGHT DISORD-ST
JI Eat. Weight Disord.-Stud. Anorex.
PD MAR
PY 2007
VL 12
IS 1
BP E19
EP E23
PG 5
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychiatry
GA 359KV
UT WOS:000259986500012
PM 17384521
DA 2025-06-11
ER

PT J
AU Pu, P
   Gao, DM
   Mohamed, S
   Chen, J
   Zhang, J
   Zhou, XY
   Zhou, NJ
   Xie, J
   Jiang, H
AF Pu, Peng
   Gao, Dong-Mei
   Mohamed, Salim
   Chen, Jing
   Zhang, Jing
   Zhou, Xiao-Ya
   Zhou, Nai-Jing
   Xie, Jing
   Jiang, Hong
TI Naringin ameliorates metabolic syndrome by activating AMP-activated
   protein kinase in mice fed a high-fat diet
SO ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
LA English
DT Article
DE Naringin; Metabolic syndrome; AMPK; Oxidative stress; Inflammation
ID INSULIN-RESISTANCE; ANTIOXIDANT STATUS; OXIDATIVE STRESS; OBESITY;
   PHOSPHORYLATION; INFLAMMATION; GLUCOSE; CHOLESTEROL; HOMEOSTASIS;
   EXPRESSION
AB Metabolic syndrome is a low-grade inflammatory state in which oxidative stress is involved. Naringin, isolated from the Citrussinensis, is a phenolic compound with anti-oxidative and anti-inflammatory activities. The aim of this study was to explore the effects of naringin on metabolic syndrome in mice. The animal models, induced by high-fat diet in C57BL/6 mice, developed obesity, dyslipidemia, fatty liver, liver dysfunction and insulin resistance. These changes were attenuated by naringin. Further investigations revealed that the inhibitory effect on inflammation and insulin resistance was mediated by blocking activation of the MAPKs pathways and by activating IRS1; the lipid-lowering effect was attributed to inhibiting the synthesis way and increasing fatty acid oxidation; the hypoglycemic effect was due to the regulation of PEPCK and G6pase. The anti-oxidative stress of naringin also participated in the improvement of insulin resistance and lipogenesis. All of these depended on the AMPK activation. To confirm the results of the animal experiment, we tested primary hepatocytes exposed to high glucose system. Naringin was protective by phosphorylating AMPK alpha and IRS1. Taken together, these results suggested that naringin protected mice exposed to a high-fat diet from metabolic syndrome through an AMPK-dependent mechanism involving multiple types of intracellular signaling and reduction of oxidative damage. (C) 2011 Elsevier Inc. All rights reserved.
C1 [Pu, Peng; Mohamed, Salim; Chen, Jing; Zhang, Jing; Zhou, Xiao-Ya; Zhou, Nai-Jing; Xie, Jing; Jiang, Hong] Wuhan Univ, Dept Cardiol, Renmin Hosp, Wuhan 430060, Peoples R China.
   [Gao, Dong-Mei] Wuhan Univ, Coll Pharm, Wuhan 430072, Hubei Province, Peoples R China.
C3 Wuhan University; Wuhan University
RP Jiang, H (corresponding author), Wuhan Univ, Dept Cardiol, Renmin Hosp, Jiefang Rd 238, Wuhan 430060, Peoples R China.
EM jianghong1958@yahoo.com.cn
FU Fundamental Research Funds for the Central Universities
   [20103020201000188, 20103020201000203]; Major Subject of Health
   Department of Hubei Province of China [JX4A02]
FX This research was supported by the Fundamental Research Funds for the
   Central Universities (20103020201000188, 20103020201000203) and the
   Major Subject of Health Department of Hubei Province of China (No.
   JX4A02).
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NR 37
TC 161
Z9 172
U1 1
U2 38
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0003-9861
EI 1096-0384
J9 ARCH BIOCHEM BIOPHYS
JI Arch. Biochem. Biophys.
PD FEB 1
PY 2012
VL 518
IS 1
BP 61
EP 70
DI 10.1016/j.abb.2011.11.026
PG 10
WC Biochemistry & Molecular Biology; Biophysics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics
GA 885TM
UT WOS:000299803700009
PM 22198281
DA 2025-06-11
ER

PT J
AU Miihlbauer, JE
   Moreira-de-Oliveira, ME
   Ribeiro, AP
   de-Salles-Andrade, JB
   Hühne, V
   de Faro, LFT
   Félix-da-Silva, C
   Menezes, GBD
   Fontenelle, LF
AF Miihlbauer, Julia E.
   Moreira-de-Oliveira, Maria E.
   Ribeiro, Ana P.
   de-Salles-Andrade, Juliana B.
   Huhne, Veronica
   de Faro, Livi F. Testoni
   Felix-da-Silva, Carina
   Menezes, Gabriela B. de
   Fontenelle, Leonardo F.
TI ASSESSING ADHERENCE TO VACCINATION, SOCIAL DISTANCING AND OTHER
   PREVENTIVE BEHAVIORS BY PATIENTS WITH MENTAL DISORDERS IN THE CONTEXT OF
   COVID-19 PANDEMIC: A SCOPING REVIEW PROTOCOL
SO CLINICAL NEUROPSYCHIATRY
LA English
DT Review
DE COVID-19 pandemic; preventive behavior; mental disorder
ID METABOLIC SYNDROME; ILLNESS; PEOPLE; DISEASE; RISK
AB The COVID-19 pandemic has emerged as a worldwide public health crisis, leading to significant disruptions in societal behaviors and norms. Within the affected population, individuals with mental health disorders are considered a vulnerable group, experiencing higher infection rates and poorer outcomes. These adverse outcomes can be attributed to various factors, including inadequate adherence to vaccination and other preventive measures. To address this issue, this study aims to present the research protocol for a scoping review that will comprehensively examine the literature on the adherence of individuals with mental disorders to preventive behaviors during the COVID-19 pandemic. The scoping review will adhere to the methodological guidelines outlined by the Joanna Briggs Institute and will be reported in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews checklist. A comprehensive search for published literature containing original data will be conducted in the Embase, MEDLINE, PsycINFO, and Web of Science databases. The search strategy will be developed based on the Population, Concept, and Context inclusion criteria. Two authors will independently screen titles, abstracts, and full texts for inclusion and extract relevant data. The findings of the review will be presented using descriptive statistics, including tables, charts, and flow diagrams, to elucidate the key concepts of interest.
C1 [Moreira-de-Oliveira, Maria E.; Huhne, Veronica; Felix-da-Silva, Carina; Menezes, Gabriela B. de; Fontenelle, Leonardo F.] Fed Univ Rio Janeiro UFRJ, Inst Psychiat, Obsess Compuls & Anxiety Spectrum Res Program, Rio De Janeiro, Brazil.
   [Moreira-de-Oliveira, Maria E.; de-Salles-Andrade, Juliana B.; Menezes, Gabriela B. de; Fontenelle, Leonardo F.] D Or Inst Res & Educ IDOR, Rio De Janeiro, Brazil.
   [Fontenelle, Leonardo F.] Fed Univ Rio Janeiro, Ave Venceslau Bras,71,Botafogo, BR-22290140 Rio De Janeiro, RJ, Brazil.
RP Fontenelle, LF (corresponding author), Fed Univ Rio Janeiro, Ave Venceslau Bras,71,Botafogo, BR-22290140 Rio De Janeiro, RJ, Brazil.
EM lfontenelle@gmail.com
RI Fontenelle, Leonardo/D-3321-2013
OI Huhne, Veronica/0000-0001-7906-6915
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NR 38
TC 0
Z9 0
U1 0
U2 1
PU GIOVANNI FIORITI EDITORE
PI ROME
PA VIA ARCHIMEDE 179, ROME, 00197, ITALY
SN 1724-4935
EI 2385-0787
J9 CLIN NEUROPSYCHIATR
JI Clin. Neuropsychiatr.
PD AUG
PY 2023
VL 20
IS 4
BP 288
EP 292
DI 10.17605/OSF.IO/STKBV
PG 5
WC Clinical Neurology; Psychiatry
WE Emerging Sources Citation Index (ESCI)
SC Neurosciences & Neurology; Psychiatry
GA IQ6Z5
UT WOS:001167846700011
PM 37791088
DA 2025-06-11
ER

PT J
AU Happell, B
   Scott, D
   Platania-Phung, C
AF Happell, Brenda
   Scott, David
   Platania-Phung, Chris
TI Nurse views on the cardiometabolic health nurse as an approach to
   improving the physical health of people with serious mental illness in
   Australia
SO INTERNATIONAL JOURNAL OF MENTAL HEALTH NURSING
LA English
DT Article
DE cardiometabolic health nurse; cardiovascular disease; diabetes; physical
   health; serious mental illness
ID PRIMARY-CARE; MEDICAL-CARE; PERCEIVED BARRIERS; METABOLIC SYNDROME;
   RANDOMIZED-TRIAL; RISK-FACTORS; SCHIZOPHRENIA; COMMUNITY; MORTALITY;
   ACCESS
AB People with serious mental illness (SMI) die prematurely from common physical illnesses such as cardiovascular disease and diabetes. These cardiometabolic risks are preventable and manageable yet these aspects of health care have been neglected in mental health services. A potential nurse-based strategy to decisively improve cardiometabolic health of people with SMI is to introduce a cardiometabolic health nurse (CHN) into mental health services. The current study aimed to establish the views of nurses working in mental health care on the potential benefits and limits of CHN to improve physical health-care standards in Australia. All members of the Australian College of Mental Health Nurses were invited to participate in an online survey and 643 participated. Nurses generally agreed that a CHN role would provide a range of improvements to physical health care, such as increased detection, assessment on, and follow up of cardiometabolic risks, and decreased workload for other nurses. While participants were generally supportive of such a role, they felt it would not be suitable in all health-care settings in Australia.
C1 [Happell, Brenda] Cent Queensland Univ, Inst Hlth & Social Sci Res, Ctr Mental Hlth Nursing Innovat, Rockhampton, Qld 4702, Australia.
   Cent Queensland Univ, Sch Nursing & Midwifery, Rockhampton, Qld 4702, Australia.
C3 Central Queensland University; Central Queensland University
RP Happell, B (corresponding author), Cent Queensland Univ, Inst Hlth & Social Sci Res, Ctr Mental Hlth Nursing Innovat, Rockhampton, Qld 4702, Australia.
EM b.happell@cqu.edu.au
RI Scott, David/AAE-5031-2021; Happell, Brenda/HSI-0570-2023
OI Scott, David/0000-0001-5226-1972; Happell, Brenda/0000-0002-7293-6583
FU Central Queensland University
FX The authors would like to thank the mental health nurses for their time
   and valuable input. Our thanks to the ACMHN, particularly Kim Ryan and
   Haylie Maylia, for their invaluable assistance in distributing the
   survey. The Research Advancement Award Scheme and Merit Grant Scheme of
   Central Queensland University provided the funding to make this work
   possible.
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NR 74
TC 13
Z9 13
U1 0
U2 22
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1445-8330
EI 1447-0349
J9 INT J MENT HEALTH NU
JI Int. J. Ment. Health Nurs.
PD OCT
PY 2013
VL 22
IS 5
BP 418
EP 429
DI 10.1111/j.1447-0349.2012.00892.x
PG 12
WC Nursing; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Psychiatry
GA 202IZ
UT WOS:000323209200007
PM 23211091
DA 2025-06-11
ER

PT J
AU Abrams, DI
AF Abrams, Donald I.
TI The therapeutic effects of Cannabis and cannabinoids: An update
   from the National Academies of Sciences, Engineering and Medicine report
SO EUROPEAN JOURNAL OF INTERNAL MEDICINE
LA English
DT Review
ID CROSS-SECTIONAL SURVEY; EFFICACY; COMBINATION; DRONABINOL; EPILEPSY
AB The National Academies of Sciences, Engineering and Medicine conducted a rapid turn-around comprehensive review of recent medical literature on The Health Effects of Cannabis and Cannabinoids. The 16-member committee adopted the key features of a systematic review process, conducting an extensive search of relevant databases and considered 10,000 recent abstracts to determine their relevance. Primacy was given to recently published systematic reviews and primary research that studied one of the committee's 11 prioritized health endpoints-therapeutic effects; cancer incidence; cardiometabolic risk; respiratory disease; immune function; injury and death; prenatal, perinatal and postnatal outcomes; psychosocial outcomes; mental health; problem Cannabis use; and Cannabis use and abuse of other substances. The committee developed standard language to categorize the weight of evidence regarding whether Cannabis or cannabinoids use for therapeutic purposes are an effective or ineffective treatment for the prioritized health endpoints of interest. In the Therapeutics chapter reviewed here, the report concluded that there was conclusive or substantial evidence that Cannabis or cannabinoids are effective for the treatment of pain in adults; chemotherapy-induced nausea and vomiting and spasticity associated with multiple sclerosis. Moderate evidence was found for secondary sleep disturbances. The evidence supporting improvement in appetite, Tourette syndrome, anxiety, posttraumatic stress disorder, cancer, irritable bowel syndrome, epilepsy and a variety of neurodegenerative disorders was described as limited, insufficient or absent. A chapter of the NASEM report enumerated multiple barriers to conducting research on Cannabis in the US that may explain the paucity of positive therapeutic benefits in the published literature to date.
C1 [Abrams, Donald I.] Univ Calif San Francisco, Zuckerberg San Francisco Gen Hosp, Clin Med, Hematol Oncol, Ward 84,995 Potrero Ave, San Francisco, CA 94110 USA.
C3 University of California System; University of California San Francisco
RP Abrams, DI (corresponding author), Univ Calif San Francisco, Zuckerberg San Francisco Gen Hosp, Clin Med, Hematol Oncol, Ward 84,995 Potrero Ave, San Francisco, CA 94110 USA.
EM Donald.Abrams@ucsf.edu
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NR 31
TC 198
Z9 217
U1 3
U2 98
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0953-6205
EI 1879-0828
J9 EUR J INTERN MED
JI Eur. J. Intern. Med.
PD MAR
PY 2018
VL 49
BP 7
EP 11
DI 10.1016/j.ejim.2018.01.003
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA FY6QP
UT WOS:000426979900003
PM 29325791
DA 2025-06-11
ER

PT J
AU Kalucy, MJ
   Grunstein, R
   Lambert, T
   Glozier, N
AF Kalucy, Megan J.
   Grunstein, Ron
   Lambert, Timothy
   Glozier, Nicholas
TI Obstructive sleep apnoea and schizophrenia - A research agenda
SO SLEEP MEDICINE REVIEWS
LA English
DT Review
DE Obstructive sleep apnoea; Schizophrenia; Sleep; CPAP; Review; Metabolic
   syndrome
ID SLOW-WAVE SLEEP; POSITIVE AIRWAY PRESSURE; DRUG-NAIVE PATIENTS; VISCERAL
   FAT DISTRIBUTION; ANTIPSYCHOTIC MEDICATIONS; DAYTIME SLEEPINESS;
   METABOLIC SYNDROME; UNTREATED PATIENTS; GLUCOSE-TOLERANCE; HYPOPNEA
   SYNDROME
AB Schizophrenia is associated with significantly increased physical morbidity and mortality particularly secondary to cardiometabolic disorders. In people with schizophrenia, rates of obesity and the metabolic syndrome are high compared to the general population. Whilst the weight gain secondary to antipsychotic medication is largely to blame, other factors include inactivity, poor diet and possibly the illness itself. Obstructive sleep apnoea (OSA) is a common and frequently under-recognized condition which may be associated with disabling symptoms including daytime sleepiness, cognitive impairment, depression, anxiety and long term increases in morbidity and mortality secondary to cardiometabolic disease. As the primary risk factor is obesity, elevated rates of sleep apnoea would therefore seem likely in association with schizophrenia. Thus, USA might represent a treatable cause of psychiatric and physical co-morbidity in patients with schizophrenia. A review of the literature revealed a paucity of quality research in this area. Available data suggest increased rates of sleep apnoea in schizophrenia and that psychotic symptoms may improve when co-morbid sleep apnoea is treated. Health practitioners may be unaware of the need to screen for sleep apnoea in patients with schizophrenia and the disorder may be significantly under-recognised. Research is required to clarify the epidemiology, consequences and management of sleep apnoea in association with schizophrenia. (C) 2012 Elsevier Ltd. All rights reserved.
C1 [Kalucy, Megan J.; Grunstein, Ron] Woolcock Clin, Glebe, NSW 2037, Australia.
   [Grunstein, Ron; Glozier, Nicholas] Univ Sydney, Sydney Med Sch, NHMRC Ctr Integrated Res & Understanding Sleep CI, Sydney, NSW 2006, Australia.
   [Lambert, Timothy; Glozier, Nicholas] Univ Sydney, Sydney Med Sch, Discipline Psychiat, Brain & Mind Res Inst, Sydney, NSW 2006, Australia.
C3 University of Sydney; Woolcock Institute of Medical Research; University
   of Sydney; University of Sydney
RP Kalucy, MJ (corresponding author), Woolcock Clin, 431 Glebe Point Rd, Glebe, NSW 2037, Australia.
EM m.kalucy@me.com; rrg@med.usyd.edu.au; tim.lambert@sydney.edu.au;
   nick.glozier@sydney.edu.au
RI Glozier, Nick/A-7440-2011
OI Glozier, Nick/0000-0002-0476-9146; Grunstein, Ronald/0000-0001-6682-5812
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NR 111
TC 37
Z9 39
U1 0
U2 34
PU W B SAUNDERS CO LTD
PI LONDON
PA 32 JAMESTOWN RD, LONDON NW1 7BY, ENGLAND
SN 1087-0792
EI 1532-2955
J9 SLEEP MED REV
JI Sleep Med. Rev.
PD OCT
PY 2013
VL 17
IS 5
BP 357
EP 365
DI 10.1016/j.smrv.2012.10.003
PG 9
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 208PI
UT WOS:000323691200006
PM 23528272
DA 2025-06-11
ER

PT J
AU Sharma, H
   Kumar, S
AF Sharma, Hitender
   Kumar, Sunil
TI Natural AMPK Activators: An Alternative Approach for the Treatment and
   Management of Metabolic Syndrome
SO CURRENT MEDICINAL CHEMISTRY
LA English
DT Review
DE Cardiovascular disorders; diabetes; obesity; metabolic syndrome;
   transcription factors; phytoconstituents
ID HIGH-FAT-DIET; PROTEIN-KINASE AMPK; SKELETAL-MUSCLE CELLS; INDUCED
   INSULIN-RESISTANCE; ATTENUATES LIPID-ACCUMULATION; ENDOPLASMIC-RETICULUM
   STRESS; HEPATIC GLUCOSE-PRODUCTION; INDUCED OBESE MICE; HUMAN HEPG2
   CELLS; INHIBITS ADIPOCYTE DIFFERENTIATION
AB This review covers recent discoveries of phytoconstituents, herbal extracts and some semi-synthetic compounds for treating metabolic syndrome with AMPK activation as one of their mechanisms of action. Recent researches have demonstrated AMPK activation to ameliorate multiple components of metabolic syndrome by regulating a balance between anabolic and catabolic cellular reactions. The review attempts to delineate the AMPK activation by natural agents from the perspective of its functional consequences on enzymes, transcription factors and signaling molecules and also on other potential factors contributing in the amelioration of metabolic syndrome.
C1 [Sharma, Hitender; Kumar, Sunil] Kurukshetra Univ, Inst Pharmaceut Sci, Kurukshetra 136119, Haryana, India.
C3 Kurukshetra University
RP Kumar, S (corresponding author), Kurukshetra Univ, Inst Pharmaceut Sci, Kurukshetra 136119, Haryana, India.
EM sunilmadhuban@yahoo.com
RI Sharma, Hitender/KXQ-9758-2024; Kumar, Sunil/ABF-5435-2021; Kumar,
   Sunil/F-5301-2019
OI , Hitender/0000-0003-0540-7574; Kumar, Sunil/0000-0002-5905-3372
FU DST-SERB, New Delhi [SB/FTP/ETA-0358/2013]
FX Authors are thankful to DST-SERB, New Delhi for honoring Dr. Sunil Kumar
   with Fast Track Young Scientist and financially supporting to research
   work [F. No. SB/FTP/ETA-0358/2013].
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NR 306
TC 15
Z9 16
U1 0
U2 21
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 0929-8673
EI 1875-533X
J9 CURR MED CHEM
JI Curr. Med. Chem.
PY 2017
VL 24
IS 10
BP 1007
EP 1047
DI 10.2174/0929867323666160406120814
PG 41
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Pharmacology &
   Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
GA EW0UA
UT WOS:000402205500006
PM 27048379
DA 2025-06-11
ER

PT J
AU Ueno, H
   Saitoh, Y
   Mizuta, M
   Shiiya, T
   Noma, K
   Mashiba, S
   Kojima, S
   Nakazato, M
AF Ueno, Hiroaki
   Saitoh, Yukie
   Mizuta, Masanari
   Shiiya, Tomomi
   Noma, Kenji
   Mashiba, Shinichi
   Kojima, Shiho
   Nakazato, Masamitsu
TI Fenofibrate ameliorates insulin resistance, hypertension and novel
   oxidative stress markers in patients with metabolic syndrome
SO OBESITY RESEARCH & CLINICAL PRACTICE
LA English
DT Article
DE Fenofibrate; Metabolic syndrome; Insulin resistance; Hypertension;
   Oxidative stress
ID ACTIVATED RECEPTOR-ALPHA; C-REACTIVE PROTEIN; TYPE-2 DIABETES-MELLITUS;
   PPAR-ALPHA; GENE-EXPRESSION; KAPPA-B; INFLAMMATION; ADIPONECTIN;
   ATHEROSCLEROSIS; GAMMA
AB Objective: The benefits of fenofibrate, a peroxisome proliferator-activated receptor alpha agonist, against cardiovascular risk factors have been established. To clarify the underlying mechanisms of these benefits, we examined the effects of fenofibrate on insulin resistance, hypertension, inflammation, oxidative stress and coagulation markers in patients with metabolic syndrome.
   Methods: Eleven Japanese patients with metabolic syndrome underwent physical examinations and blood tests before and after treatment with fenofibrate 200 mg daily for 8 weeks.
   Results: Fenofibrate significantly decreased systolic blood pressure, pulse wave velocity, serum insulin, insulin resistance (calculated from the homeostasis model assessment), total cholesterol, triglyceride, remnant-like particles cholesterol, uric acid, D-dimer, fibrinogen, serum amyloid A/low-density lipoprotein (LDL) and apoA1/LDL levels. It also significantly increased levels of high molecular weight adiponectin, thrombomodulin and high-density lipoprotein cholesterol in these patients. Plasminogen activator inhibitor-1, C-reactive protein, fasting plasma glucose and thrombin-antithrombin complex levels did not change.
   Limitation: Small sample size.
   Conclusion: Short-term fenofibrate administration not only improved lipid profiles, but also ameliorated insulin resistance, hypertension and oxidative stress markers in patients with metabolic syndrome, suggesting that fenofibrate can decrease the risk of arteriosclerosis through various pathways. (C) 2011 Asian Oceanian Association for the Study of Obesity. Published by Elsevier Ltd. All rights reserved.
C1 [Ueno, Hiroaki; Saitoh, Yukie; Mizuta, Masanari; Shiiya, Tomomi; Noma, Kenji; Nakazato, Masamitsu] Miyazaki Univ, Fac Med, Dept Internal Med, Div Neurol Respirol Endocrinol & Metab, Miyazaki 8891692, Japan.
   [Mashiba, Shinichi; Kojima, Shiho] Ikagaku Co Ltd, Kyoto, Japan.
C3 University of Miyazaki
RP Ueno, H (corresponding author), Miyazaki Univ, Fac Med, Dept Internal Med, Div Neurol Respirol Endocrinol & Metab, 5200 Kiyotake, Miyazaki 8891692, Japan.
EM intron@med.miyazaki-u.ac.jp
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PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1871-403X
EI 1878-0318
J9 OBES RES CLIN PRACT
JI Obes. Res. Clin. Pract.
PD OCT-DEC
PY 2011
VL 5
IS 4
BP E335
EP E340
DI 10.1016/j.orcp.2011.03.012
PG 6
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 981GX
UT WOS:000306956100009
PM 24331137
DA 2025-06-11
ER

PT J
AU Stogios, N
   Gdanski, A
   Gerretsen, P
   Chintoh, AF
   Graff-Guerrero, A
   Rajji, TK
   Remington, G
   Hahn, MK
   Agarwal, SM
AF Stogios, Nicolette
   Gdanski, Alexander
   Gerretsen, Philip
   Chintoh, Araba F.
   Graff-Guerrero, Ariel
   Rajji, Tarek K.
   Remington, Gary
   Hahn, Margaret K.
   Agarwal, Sri Mahavir
TI Autonomic nervous system dysfunction in schizophrenia: impact on
   cognitive and metabolic health
SO NPJ SCHIZOPHRENIA
LA English
DT Review
ID HEART-RATE-VARIABILITY; ACTING INJECTABLE ANTIPSYCHOTICS; ELECTRODERMAL
   ACTIVITY; VAGUS NERVE; NEUROVISCERAL INTEGRATION; ATYPICAL
   ANTIPSYCHOTICS; UNMEDICATED PATIENTS; PSYCHOTIC SYMPTOMS; ORIENTING
   RESPONSE; DIABETES-MELLITUS
AB Schizophrenia (SCZ) is a psychiatric disorder characterized by a wide range of positive, negative and cognitive symptoms, along with an increased risk of metabolic syndrome and cardiovascular disease that contribute to a 15-20-year reduced life expectancy. Autonomic dysfunction, in the form of increased sympathetic activity and decreased parasympathetic activity, is postulated to be implicated in SCZ and its treatment. The aim of this narrative review is to view SCZ through an autonomic lens and synthesize the evidence relating autonomic dysfunction to different domains of SCZ. Using various methods of assessing autonomic activity, autonomic dysfunction was found to be associated with multiple aspects of SCZ pathophysiology, including symptom severity, cognitive impairment, and the development of cardiometabolic comorbidities, such as metabolic syndrome and high BMI. The strongest association of low heart rate variability was noted among patients on antipsychotic treatment with high-affinity muscarinic antagonism (i.e., clozapine, olanzapine and quetiapine). The review will also suggest ways in which studying autonomic dysfunction can help reduce morbidity and mortality associated with SCZ and its treatment.
C1 [Stogios, Nicolette; Gerretsen, Philip; Graff-Guerrero, Ariel; Rajji, Tarek K.; Remington, Gary; Hahn, Margaret K.; Agarwal, Sri Mahavir] Univ Toronto, Inst Med Sci, Toronto, ON, Canada.
   [Stogios, Nicolette; Gerretsen, Philip; Chintoh, Araba F.; Graff-Guerrero, Ariel; Rajji, Tarek K.; Remington, Gary; Hahn, Margaret K.; Agarwal, Sri Mahavir] Ctr Addict & Mental Hlth CAMH, Toronto, ON, Canada.
   [Gdanski, Alexander] Univ Toronto, Human Biol Dept, Toronto, ON, Canada.
   [Gerretsen, Philip; Chintoh, Araba F.; Graff-Guerrero, Ariel; Rajji, Tarek K.; Remington, Gary; Hahn, Margaret K.; Agarwal, Sri Mahavir] Univ Toronto, Dept Psychiat, Toronto, ON, Canada.
C3 University of Toronto; University of Toronto; Centre for Addiction &
   Mental Health - Canada; University of Toronto; University of Toronto
RP Agarwal, SM (corresponding author), Univ Toronto, Inst Med Sci, Toronto, ON, Canada.; Agarwal, SM (corresponding author), Ctr Addict & Mental Hlth CAMH, Toronto, ON, Canada.; Agarwal, SM (corresponding author), Univ Toronto, Dept Psychiat, Toronto, ON, Canada.
EM mahavir.agarwal@camh.ca
RI Rajji, Tarek/K-1543-2015; Agarwal, Mahavir/ITV-3244-2023; Graff,
   Ariel/G-6624-2012; Hahn, Margaret/F-5034-2014
OI Gdanski, Alexander/0000-0002-6192-6849; Hahn,
   Margaret/0000-0001-8884-9946; Stogios, Nicolette/0000-0001-9136-4923;
   AGARWAL, SRI MAHAVIR/0000-0002-2705-5146
FU CIHR Canada Graduate Scholarship Master's Program (CGS-M); Banting and
   Best Diabetes Centre (BBDC) Novo-Nordisk Graduate Studentship;
   Department of Psychiatry, University of Toronto; Canadian Institutes of
   Health Research; CAMH Discovery Fund; Banting and Best Diabetes Center
   (BBDC); Canadian Institutes of Health Research (CIHR) [PJT-153262]; PSI
   Foundation, Ontario; Kelly and Michael Meighen Chair in Psychosis
   Prevention; PSI Foundation
FX Figures were created using Biorenders.com. N.S. is supported by the CIHR
   Canada Graduate Scholarship Master's Program (CGS-M) and the Banting and
   Best Diabetes Centre (BBDC) Novo-Nordisk Graduate Studentship. SMA is
   supported in part by an Academic Scholars Award from the Department of
   Psychiatry, University of Toronto and has grant support from the
   Canadian Institutes of Health Research, PSI Foundation, Ontario, and the
   CAMH Discovery Fund. M.K.H. is supported in part by an Academic Scholars
   Award from the Department of Psychiatry, University of Toronto and has
   grant support from the Banting and Best Diabetes Center (BBDC) through
   the New Investigator Award, Canadian Institutes of Health Research
   (PJT-153262) (CIHR), PSI Foundation, Ontario, and holds the Kelly and
   Michael Meighen Chair in Psychosis Prevention.
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NR 111
TC 53
Z9 54
U1 0
U2 11
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
EI 2334-265X
J9 NPJ SCHIZOPHR
JI npj Schizophr.
PD APR 26
PY 2021
VL 7
IS 1
AR 22
DI 10.1038/s41537-021-00151-6
PG 10
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA RT7MV
UT WOS:000644642400001
PM 33903594
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Zouridakis, EG
   Cox, ID
   Garcia-Moll, X
   Brown, S
   Nihoyannopoulos, P
   Kaski, JC
AF Zouridakis, EG
   Cox, ID
   Garcia-Moll, X
   Brown, S
   Nihoyannopoulos, P
   Kaski, JC
TI Negative stress echocardiographic responses in normotensive and
   hypertensive patients with angina pectoris, positive exercise stress
   testing, and normal coronary arteriograms
SO HEART
LA English
DT Article
DE dobutamine stress echocardiography; microvascular angina; hypertension;
   syndrome X
ID LEFT-VENTRICULAR HYPERTROPHY; ENDOTHELIUM-DEPENDENT VASODILATION;
   SYNDROME-X; CHEST PAIN; RESISTANCE VESSELS; MICROVASCULAR ANGINA;
   MYOCARDIAL PERFUSION; ARTERY DISEASE; HEART-DISEASE; RESERVE
AB Objectives-To systematically compare the results of dobutamine stress echocardiography in matched groups of hypertensive and normotensive patients with anginal chest pain and normal coronary arteriograms (CPNA).
   Setting-University hospital.
   Subjects-33 patients with exertional anginal chest pain, a positive exercise stress ECG, and a completely normal coronary arteriogram; 17 had a history of systemic hypertension (14 women; mean (SD) age 57 (6) years), and 16 had no hypertensive history (12 women; age 54 (9) years).
   Methods-Ambulatory ECG monitoring, dobutamine stress echocardiography; and thallium-201 single photon emission computed tomography (SPECT) were performed in all subjects.
   Results-All patients had normal left ventricular systolic function at rest and none fulfilled the criteria for ventricular hypertrophy. Eight normotensive patients and 10 hypertensive patients had perfusion abnormalities on thallium SPECT (p = 0.61). Dobutamine infusion reproduced anginal pain in seven normotensive and seven hypertensive patients (p = 0.88). ST segment depression was also recorded in eight normotensive patients and seven hypertensive patients (p = 0.61). No patient in either group developed regional wall motion abnormalities during dobutamine stress echocardiography.
   Conclusions-Neither hypertensive nor normotensive CPNA patients developed regional wall motion abnormalities during dobutamine stress echocardiography, despite the high prevalence of scintigraphic perfusion defects in both groups and the presence of chest pain and ST segment depression. Thus myocardial ischaemia was not present in either group, or else dobutamine stress echocardiography is insensitive to ischaemia caused by microvascular dysfunction.
C1 St Georges Hosp, Sch Med, Dept Cardiol Sci, London SW17 0RE, England.
   Hammersmith Hosp, Dept Cardiol, London W12 0HS, England.
C3 City St Georges, University of London; Imperial College London
RP Kaski, JC (corresponding author), St Georges Hosp, Sch Med, Dept Cardiol Sci, London SW17 0RE, England.
RI Kaski, Juan Carlos/LKM-8031-2024; Cox, Ian/JGE-1348-2023
OI Garcia-Moll, Xavier/0000-0001-7837-8378
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NR 37
TC 19
Z9 22
U1 0
U2 1
PU BRITISH MED JOURNAL PUBL GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 1355-6037
J9 HEART
JI Heart
PD FEB
PY 2000
VL 83
IS 2
BP 141
EP 146
DI 10.1136/heart.83.2.141
PG 6
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 281EK
UT WOS:000085144800005
PM 10648483
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Balsevich, G
   Baumann, V
   Uribe, A
   Chen, A
   Schmidt, MV
AF Balsevich, Georgia
   Baumann, Valentin
   Uribe, Andres
   Chen, Alon
   Schmidt, Mathias V.
TI Prenatal Exposure to Maternal Obesity Alters Anxiety and Stress Coping
   Behaviors in Aged Mice
SO NEUROENDOCRINOLOGY
LA English
DT Article
DE Obesity; Anxiety; Stress coping behaviors; Mice
ID HIGH-FAT DIET; PITUITARY-ADRENAL AXIS; SOCIAL DEFEAT STRESS;
   GLUCOCORTICOID-RECEPTOR; ANIMAL-MODELS; METABOLIC SYNDROME;
   GENE-EXPRESSION; HYPOTHESIS; PREGNANCY; DISEASE
AB Background: There is growing evidence that maternal obesity and prenatal exposure to a high-fat diet program fetal development to regulate the physiology and behavior of the offspring in adulthood. Yet the extent to which the maternal dietary environment contributes to adult disease vulnerability remains unclear. In the current study we tested whether prenatal exposure to maternal obesity increases the offspring's vulnerability to stress-related psychiatric disorders. Methods: We used a mouse model of maternal diet-induced obesity to investigate whether maternal obesity affects the response to adult chronic stress exposure in young adult (3-month-old) and aged adult (12-month-old) offspring. Results: Long-lasting, delayed impairments to anxiety-like behaviors and stress coping strategies resulted on account of prenatal exposure to maternal obesity. Although maternal obesity did not change the offspring's behavioral response to chronic stress per se, we demonstrate that the behavioral outcomes induced by prenatal exposure to maternal obesity parallel the deleterious effects of adult chronic stress exposure in aged male mice. We found that the glucocorticoid receptor (GR, Nr3c1) is upregulated in various hypothalamic nuclei on account of maternal obesity. In addition, gene expression of a known regulator of the GR, FKBP51, is increased specifically within the paraventricular nucleus. Conclusions: These findings indicate that maternal obesity parallels the deleterious effects of adult chronic stress exposure, and furthermore identifies GR/FKBP51 signaling as a novel candidate pathway regulated by maternal obesity. (C) 2015 S. Karger AG, Basel
C1 [Balsevich, Georgia; Uribe, Andres; Chen, Alon; Schmidt, Mathias V.] Max Planck Inst Psychiat, Dept Stress Neurobiol & Neurogenet, Kraepelinstr 2-10, DE-80804 Munich, Germany.
   [Baumann, Valentin] Helmholtz Ctr, Inst Stem Cell Res, Munich, Germany.
C3 Max Planck Society; Helmholtz Association; Helmholtz-Center Munich -
   German Research Center for Environmental Health
RP Balsevich, G (corresponding author), Max Planck Inst Psychiat, Dept Stress Neurobiol & Neurogenet, Kraepelinstr 2-10, DE-80804 Munich, Germany.
EM georgia_balsevich@mpipsykl.mpg.de
OI Balsevich, Georgia/0000-0002-7839-018X; Chen, Alon/0000-0003-3625-8233
FU European Commission [278603]
FX This work was supported by the European Commission Seventh Framework
   Programme (FP7, project No. 278603).
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NR 53
TC 27
Z9 28
U1 0
U2 16
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0028-3835
EI 1423-0194
J9 NEUROENDOCRINOLOGY
JI Neuroendocrinology
PY 2016
VL 103
IS 3-4
BP 354
EP 368
DI 10.1159/000439087
PG 15
WC Endocrinology & Metabolism; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology
GA DL6RO
UT WOS:000375766500017
PM 26279463
DA 2025-06-11
ER

PT J
AU Zhuo, CJ
   Liu, W
   Jiang, RH
   Li, RL
   Yu, HP
   Chen, GD
   Shan, JM
   Zhu, JJ
   Cai, ZY
   Lin, CG
   Cheng, LL
   Xu, Y
   Liu, S
   Luo, QH
   Jin, SL
   Liu, CX
   Chen, JY
   Wang, LA
   Yang, L
   Zhang, QY
   Li, QC
   Tian, HJ
   Song, XQ
AF Zhuo, Chuanjun
   Liu, Wei
   Jiang, Ronghuan
   Li, Ranli
   Yu, Haiping
   Chen, Guangdong
   Shan, Jianmin
   Zhu, Jingjing
   Cai, Ziyao
   Lin, Chongguang
   Cheng, Langlang
   Xu, Yong
   Liu, Sha
   Luo, Qinghua
   Jin, Shili
   Liu, Chuanxin
   Chen, Jiayue
   Wang, Lina
   Yang, Lei
   Zhang, Qiuyu
   Li, Qianchen
   Tian, Hongjun
   Song, Xueqin
CA China multiple organs damagein mental disorder CMODMD Grp
TI Metabolic risk factors of cognitive impairment in young women with major
   psychiatric disorder
SO FRONTIERS IN PSYCHIATRY
LA English
DT Article
DE major psychiatric disorder; metabolic syndrome; HbA1c; cognitive
   impairment; risk factors
ID DEVELOPMENTAL COURSE; SCHIZOPHRENIA; METAANALYSIS; ANTIPSYCHOTICS;
   PREVALENCE; PSYCHOSIS; VALIDITY; DEFICITS; SURGERY; ILLNESS
AB BackgroundCognitive performance improves clinical outcomes of patients with major psychiatric disorder (MPD), but is impaired by hyperglycemia. Psychotropic agents often induce metabolism syndrome (MetS). The identification of modifiable metabolic risk factors of cognitive impairment may enable targeted improvements of patient care. ObjectiveTo investigate the relationship between MetS and cognitive impairment in young women with MPD, and to explore risk factors. MethodsWe retrospectively studied women of 18-34 years of age receiving psychotropic medications for first-onset schizophrenia (SCH), bipolar disorder (BP), or major depressive disorder (MDD). Data were obtained at four time points: presentation but before psychotropic medication; 4-8 and 8-12 weeks of psychotropic therapy; and enrollment. MATRICS Consensus Cognitive Battery, (MCCB)-based Global Deficit Scores were used to assess cognitive impairment. Multiple logistic analysis was used to calculate risk factors. Multivariate models were used to investigate factors associated with cognitive impairment. ResultsWe evaluated 2,864 participants. Cognitive impairment was observed in 61.94% of study participants, and was most prevalent among patients with BP (69.38%). HbA1c within the 8-12 week-treatment interval was the most significant risk factor and highest in BP. Factors in SCH included pre-treatment waist circumference and elevated triglycerides during the 8-12 weeks treatment interval. Cumulative dosages of antipsychotics, antidepressants, and valproate were associated with cognitive impairment in all MPD subgroups, although lithium demonstrated a protect effect (all P < 0.001). ConclusionsCognitive impairment was associated with elevated HbA1c and cumulative medication dosages. Pre-treatment waist circumference and triglyceride level at 8-12 weeks were risk factors in SCH. Monitoring these indices may inform treatment revisions to improve clinical outcomes.
C1 [Zhuo, Chuanjun] Tianjin Fourth Ctr Hosp, Dept Psychiat, Tianjin, Peoples R China.
   [Zhuo, Chuanjun] Zhengzhou Univ, Affiliated Hosp 1, Dept Psychiat, Zhengzhou, Peoples R China.
   [Zhuo, Chuanjun; Song, Xueqin] Zhengzhou Univ, Henan Psychiat Transformat Res Key Lab, Zhengzhou, Peoples R China.
   [Zhuo, Chuanjun] Multiple Organs Damage Mental Disorder MODMD Ctr W, Wenzhou, Peoples R China.
   [Zhuo, Chuanjun; Wang, Lina] Tianjin Anding Hosp, Dept Psychiat, Tianjin, Peoples R China.
   [Liu, Wei] Harbin Med Univ, Affiliated Hosp 1, Dept Psychiat, Harbin, Peoples R China.
   [Jiang, Ronghuan] Gen Hosp PLA, Dept Psychiat, Beijing, Peoples R China.
   [Li, Ranli] Tianjin Med Univ, Tianjin Anding Hosp, Key Lab Psychiat Neuroimaging Genet & Cor morbid, Tianjin Mental Hlth Ctr, Tianjin, Peoples R China.
   [Yu, Haiping; Chen, Guangdong; Shan, Jianmin; Zhu, Jingjing; Cai, Ziyao; Lin, Chongguang; Cheng, Langlang] Wenzhou Seventh Peoples Hosp, Inpatient Dept, Wenzhou, Peoples R China.
   [Xu, Yong; Liu, Sha] Shanxi Med Univ, Hosp 1, Dept Psychiat, Clin Med Coll 1, Taiyuan, Peoples R China.
   [Luo, Qinghua] Chongqing Med Univ, Affiliated Hosp 1, Dept Psychiat, Chongqing, Peoples R China.
   [Jin, Shili; Liu, Chuanxin] Shandong Daizhuang Hosp, Inpatient Dept, Jining, Peoples R China.
   [Chen, Jiayue] Tianjin Fourth Ctr Hosp, Dept Psychiat, Tianjin, Peoples R China.
   [Yang, Lei] Yanan Fifth Hosp, Dept Psychiat, Yanan, Peoples R China.
   [Zhang, Qiuyu] Tianjin Anning Hosp, Dept Psychiat, Tianjin, Peoples R China.
   [Li, Qianchen] Hebei Fifth Peoples Hosp, Dept Psychiat, Shijiazhuang, Peoples R China.
   [Tian, Hongjun] Tianjin Med Univ, Nankai Univ,Affiliated Tianjin Ctr Hosp 4, Key Lab Multiple Organ Damage Patients Mental Diso, Tianjin Fourth Ctr Hosp, Tianjin, Peoples R China.
   [Song, Xueqin] Zhengzhou Univ, Affiliated Hosp 1, Dept Psychiat, Zhengzhou, Peoples R China.
C3 Zhengzhou University; Zhengzhou University; Harbin Medical University;
   Tianjin Medical University; Shanxi Medical University; Chongqing Medical
   University; Tianjin Medical University; Nankai University; Zhengzhou
   University
RP Zhuo, CJ (corresponding author), Tianjin Fourth Ctr Hosp, Dept Psychiat, Tianjin, Peoples R China.; Zhuo, CJ (corresponding author), Zhengzhou Univ, Affiliated Hosp 1, Dept Psychiat, Zhengzhou, Peoples R China.; Zhuo, CJ; Song, XQ (corresponding author), Zhengzhou Univ, Henan Psychiat Transformat Res Key Lab, Zhengzhou, Peoples R China.; Zhuo, CJ (corresponding author), Multiple Organs Damage Mental Disorder MODMD Ctr W, Wenzhou, Peoples R China.; Zhuo, CJ (corresponding author), Tianjin Anding Hosp, Dept Psychiat, Tianjin, Peoples R China.; Luo, QH (corresponding author), Chongqing Med Univ, Affiliated Hosp 1, Dept Psychiat, Chongqing, Peoples R China.; Tian, HJ (corresponding author), Tianjin Med Univ, Nankai Univ,Affiliated Tianjin Ctr Hosp 4, Key Lab Multiple Organ Damage Patients Mental Diso, Tianjin Fourth Ctr Hosp, Tianjin, Peoples R China.; Song, XQ (corresponding author), Zhengzhou Univ, Affiliated Hosp 1, Dept Psychiat, Zhengzhou, Peoples R China.
EM chuanjunzhuotjmh@163.com; zhangjl12141029@sina.com; thj-home@163.com;
   fccsongxq@zzu.edu.cn
RI zhang, qiuyu/JOZ-6737-2023; liu, wenli/JFA-5102-2023; wang,
   lina/HGC-1592-2022; liu, sha/JXL-6600-2024; Chen,
   guangdong/MTB-8966-2025
FU National Natural Science Foundation of China [81871052, 82171503]; Key
   Projects of the Natural Science Foundation of Tianjin, China
   [17JCZDJC35700]; Tianjin Health Bureau Foundation [2014KR02]; Tianjin
   Science and Technology Bureau [15JCYBJC50800]
FX This work was supported by grants from the National Natural Science
   Foundation of China (81871052, 82171503 to CZ), the Key Projects of the
   Natural Science Foundation of Tianjin, China (17JCZDJC35700 to CZ), the
   Tianjin Health Bureau Foundation (2014KR02 to CZ), and the Tianjin
   Science and Technology Bureau (15JCYBJC50800 to HT).
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NR 75
TC 6
Z9 5
U1 2
U2 16
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-0640
J9 FRONT PSYCHIATRY
JI Front. Psychiatry
PD JUL 29
PY 2022
VL 13
AR 880031
DI 10.3389/fpsyt.2022.880031
PG 11
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 3U0NE
UT WOS:000840666100001
PM 35966480
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Sethi, S
   Wakeham, D
   Ketter, T
   Hooshmand, F
   Bjornstad, J
   Richards, B
   Westman, E
   Krauss, RM
   Saslow, L
AF Sethi, Shebani
   Wakeham, Diane
   Ketter, Terence
   Hooshmand, Farnaz
   Bjornstad, Julia
   Richards, Blair
   Westman, Eric
   Krauss, Ronald M.
   Saslow, Laura
TI Ketogenic Diet Intervention on Metabolic and Psychiatric Health in
   Bipolar and Schizophrenia: A Pilot Trial
SO PSYCHIATRY RESEARCH
LA English
DT Article
DE Bipolar illness; Schizoaffective disorder; Ketogenic diet metabolic
   therapy; Insulin resistance; Obesity; Metabolic psychiatry; Metabolic
   syndrome; Psychiatric disease; Clinical trial; Mental health
ID BRAIN INSULIN-RESISTANCE; GLYCEMIC CONTROL; MECHANISMS; DEPRESSION;
   PSYCHOPATHOLOGY; PATHOPHYSIOLOGY; DYSREGULATION; PIOGLITAZONE;
   ASSOCIATION; DISORDERS
AB The ketogenic diet (KD, also known as metabolic therapy) has been successful in the treatment of obesity, type 2 diabetes, and epilepsy. More recently, this treatment has shown promise in the treatment of psychiatric illness. We conducted a 4-month pilot study to investigate the effects of a KD on individuals with schizophrenia or bipolar disorder with existing metabolic abnormalities. Twenty-three participants were enrolled in a single-arm trial. Results showcased improvements in metabolic health, with no participants meeting metabolic syndrome criteria by study conclusion. Adherent individuals experienced significant reduction in weight (12 %), BMI (12 %), waist circumference (13 %), and visceral adipose tissue (36 %). Observed biomarker enhancements in this population include a 27 % decrease in HOMA-IR, and a 25 % drop in triglyceride levels. In psychiatric measurements, participants with schizophrenia showed a 32 % reduction in Brief Psychiatric Rating Scale scores. Overall Clinical Global Impression (CGI) severity improved by an average of 31 %, and the proportion of participants that started with elevated symptomatology improved at least 1-point on CGI (79 %). Psychiatric outcomes across the cohort encompassed increased life satisfaction (17 %) and enhanced sleep quality (19 %). This pilot trial underscores the potential advantages of adjunctive ketogenic dietary treatment in individuals grappling with serious mental illness.
C1 [Sethi, Shebani; Wakeham, Diane; Ketter, Terence; Hooshmand, Farnaz; Bjornstad, Julia] Stanford Univ, Dept Psychiat & Behav Sci, Med, Stanford, CA 94305 USA.
   [Westman, Eric] Duke Univ, Med Ctr, Dept Med, Durham, NC USA.
   [Krauss, Ronald M.] Univ Calif San Francisco, Dept Med, San Francisco, CA USA.
   [Richards, Blair; Saslow, Laura] Univ Michigan, Sch Nursing, Dept Hlth Behav & Biol Sci, Ann Arbor, MI USA.
   [Sethi, Shebani] 401 Quarry Rd Ste 2114,MC 5723, Stanford, CA 94305 USA.
C3 Stanford University; Duke University; University of California System;
   University of California San Francisco; University of Michigan System;
   University of Michigan
RP Sethi, S (corresponding author), 401 Quarry Rd Ste 2114,MC 5723, Stanford, CA 94305 USA.
EM shebanis@stanford.edu
RI Krauss, Ronald M./LTD-4078-2024
OI Sethi, Shebani/0000-0001-6938-2471; Saslow, Laura/0000-0003-3991-3205;
   Wakeham, Diane/0000-0001-9893-372X
FU Baszucki Group, Kuen Lau Fund; Obesity Treatment Foundation
FX This work was supported by Baszucki Group, Kuen Lau Fund and the Obesity
   Treatment Foundation that was awarded to Dr. Shebani Sethi.
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NR 91
TC 39
Z9 40
U1 24
U2 31
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0165-1781
EI 1872-7123
J9 PSYCHIAT RES
JI Psychiatry Res.
PD MAY
PY 2024
VL 335
AR 115866
DI 10.1016/j.psychres.2024.115866
EA MAR 2024
PG 10
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA QW5G8
UT WOS:001223914200001
PM 38547601
OA hybrid
HC Y
HP Y
DA 2025-06-11
ER

PT J
AU Laight, DW
AF Laight, DW
TI Future anti-inflammatory metabolic and cardiovascular management of Type
   2 diabetes mellitus
SO EXPERT OPINION ON THERAPEUTIC PATENTS
LA English
DT Review
DE cardiovascular disease; endothelial dysfunction; inflammation; insulin
   resistance; nitric oxide (NO); oxidant stress; syndrome X; Type 2
   diabetes mellitus
ID OXYGEN SPECIES GENERATION; FACTOR-KAPPA-B; C-REACTIVE PROTEIN;
   INSULIN-RESISTANCE; ENDOTHELIAL DYSFUNCTION; ADHESION MOLECULES;
   MONONUCLEAR-CELLS; OXIDATIVE DAMAGE; EMERGING ROLE; INFLAMMATION
AB Although vascular inflammation is now accepted as a principal agent of atherosclerotic cardiovascular disease, much less is known concerning the dysmetabolic roles of low-grade chronic inflammatory events that often accompany obesity, insulin resistance and the metabolic syndrome or syndrome X. However, it is becoming apparent that current insulin-sensitising antihyperglycaemic therapy, represented by the biguanide metformin and the thiazolidionediones (TZD) pioglitazone and rosiglitazone, may exert powerful adjunctive anti-inflammatory actions with the potential to modify not only dysmetabolic cardiovascular disease but also Type 2 diabetes mellitus (T2DM) incidence. Such anti-inflammatory attributes may be shared by a variety of diverse traditional cardiovascular therapies, including renin-angiotensin system inhibitors, oestrogen receptor modulators, beta(1)-adrenoceptor blockers, statins, fibrates and aspirin, as well as insulin itself. Recognising the relationships between inflammatory mediators and processes, and the pathophysiology of oxidative stress, vascular endothelial dysfunction, insulin resistance and pancreatic beta-cell decompensation, is likely to introduce a new treatment paradigm in the management of syndrome X, T2DM and dysmetabolic cardiovascular disease. Such a paradigm, in addition to justifying the further development of anti-inflammatory TZD and non-TZD peroxisome proliferator-activated receptor-gamma agonists, can also be expected to clinically target markers of systemic inflammation, cell adhesion molecule expression, mononucleocyte activation, reactive oxygen species generation, and intracellular redox-sensitive, pro-inflammatory transcription factor activation. Anti-inflammatory treatment modalities may therefore therapeutically exploit the common inflammatory basis of metabolic and cardiovascular disease.
C1 Univ Portsmouth, Sch Pharm & Biomed Sci, Portsmouth PO1 2DT, Hants, England.
C3 University of Portsmouth
RP Univ Portsmouth, Sch Pharm & Biomed Sci, White Swan Rd, Portsmouth PO1 2DT, Hants, England.
EM david.laight@port.ac.uk
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NR 85
TC 1
Z9 1
U1 0
U2 1
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1354-3776
EI 1744-7674
J9 EXPERT OPIN THER PAT
JI Expert Opin. Ther. Patents
PD NOV
PY 2003
VL 13
IS 11
BP 1683
EP 1689
PG 7
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 742JY
UT WOS:000186514700001
DA 2025-06-11
ER

PT J
AU Ofosu, FK
   Mensah, DJF
   Daliri, EBM
   Oh, DH
AF Ofosu, Fred Kwame
   Mensah, Dylis-Judith Fafa
   Daliri, Eric Banan-Mwine
   Oh, Deog-Hwan
TI Exploring Molecular Insights of Cereal Peptidic Antioxidants in
   Metabolic Syndrome Prevention
SO ANTIOXIDANTS
LA English
DT Review
DE cereal grains; antioxidant peptides; oxidative stress; metabolic
   syndrome; functional food
ID INDUCED OXIDATIVE STRESS; BIOACTIVE PEPTIDES; UNITED-STATES;
   IDENTIFICATION; PROTEIN; MECHANISM; PREVALENCE; EXTRACT
AB The prevalence of metabolic syndrome (MetS) is presently an alarming public health problem globally. Oxidative stress has been postulated to be strongly correlated with MetS, such as type 2 diabetes, obesity, hypertension, cardiovascular diseases, and certain cancers. Cereals are important staple foods which account for a huge proportion of the human diet. However, owing to recent growing demand and the search for natural antioxidants for the prevention and management of MetS, cereal peptides have gained increasing attention for developing functional ingredients or foods with substantial antioxidant properties. This review explores the current production techniques for cereal peptidic antioxidants and their potential mechanism of action in the prevention and management of MetS.
C1 [Ofosu, Fred Kwame; Daliri, Eric Banan-Mwine; Oh, Deog-Hwan] Kangwon Natl Univ, Dept Food Sci & Biotechnol, Coll Agr & Life Sci, Chunchon 24341, Gangwon Do, South Korea.
   [Mensah, Dylis-Judith Fafa] Illinois State Univ, Dept Family & Consumer Sci, Coll Appl Sci & Technol, Normal, IL 61761 USA.
C3 Kangwon National University; Illinois State University
RP Oh, DH (corresponding author), Kangwon Natl Univ, Dept Food Sci & Biotechnol, Coll Agr & Life Sci, Chunchon 24341, Gangwon Do, South Korea.
EM ofosufk17@kangwon.ac.kr; dylisjudithmensah@gmail.com;
   ericdaliri@yahoo.com; deoghwa@kangwon.ac.kr
RI Daliri, Eric Banan-Mwine/JQV-7944-2023; DeogHwan, Oh/AHE-4751-2022
OI Godson, Dylis-Judith Fafa/0000-0001-7683-7139; Ofosu, Fred
   Kwame/0000-0003-1333-9030; Daliri, Eric/0000-0003-1039-0287; DeogHwan,
   Oh/0000-0002-7472-0436
FU Cooperative Research Program for Agriculture Science and Technology 602
   Development [PJ0145652021]; Rural Development Administration, Korea
FX This work was supported and funded by the Cooperative Research Program
   for Agriculture Science and Technology 602 Development (Project No.
   PJ0145652021), Rural Development Administration, Korea.
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NR 186
TC 13
Z9 13
U1 2
U2 26
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD APR
PY 2021
VL 10
IS 4
AR 518
DI 10.3390/antiox10040518
PG 28
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA RQ9FA
UT WOS:000642716300001
PM 33810450
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Eldakhakhny, B
   Bima, A
   Alamoudi, AA
   Alnami, A
   Abo-Elkhair, SM
   Sakr, H
   Almoghrabi, Y
   Ghoneim, FM
   Nagib, RM
   Elsamanoudy, A
AF Eldakhakhny, Basmah
   Bima, Abdulhadi
   Alamoudi, Aliaa A.
   Alnami, Abrar
   Abo-Elkhair, Salwa Mohamed
   Sakr, Hussein
   Almoghrabi, Yousef
   Ghoneim, Fatma Mohamed
   Nagib, Reham Mohamed
   Elsamanoudy, Ayman
TI The role of low-carbohydrate, high-fat diet in modulating autophagy and
   endoplasmic reticulum stress in aortic endothelial dysfunction of
   metabolic syndrome animal model
SO FRONTIERS IN NUTRITION
LA English
DT Article
DE metabolic syndrome; endothelial dysfunction; oxidative stress;
   endoplasmic reticulum stress; autophagy; low-carbohydrate; high-fat diet
ID INSULIN-RESISTANCE; KETOGENIC DIET; KETONE-BODIES; APOPTOSIS;
   MECHANISMS; EXPRESSION; TRANSCRIPTION; MITOCHONDRIA; ACTIVATION; SYSTEM
AB Background Endothelial dysfunction (ED) is induced by insulin resistance, mediated by endoplasmic reticulum (ER) stress and disturbed autophagy. This study investigates the protective role of a low-carbohydrate, high-fat (LCHF) diet on ED, ER stress, and autophagy dysregulation in an experimental animal model of metabolic syndrome.Methods Forty male Sprague-Dawley rats were divided into four groups: a Control group (standard diet) and three Dexamethasone (DEX) treated groups. Group II continued the standard diet, Group III received an LCHF diet, and Group IV received a high-carbohydrate, low-fat (HCLF) diet. At the end of the experiment, aortic tissue samples were obtained and used for histological, immunohistochemical (Endothelin and PCNA, biochemical MDA, TCA, NO, 8-OH-dG, and Nrf2/ARE protein) and molecular (Endothelin, eNOS, Nrf-2 alpha, p62, LC3, BECN-1, PINK1, CHOP, BNIP3, PCNA) analysis.Results Oxidative stress, autophagy markers, and ED markers are increased in the metabolic syndrome group. LCHF diet mitigates the adverse effects of DEX on endothelial dysfunction and oxidative stress, as evidenced by reduced BMI, HOMA-IR, and improved histological and molecular parameters.Conclusion Oxidative stress, autophagy dysregulation, and ER stress play crucial roles in the pathogenesis of insulin resistance-induced endothelial dysfunction. An LCHF diet offers protective benefits against insulin resistance and related comorbidities, including endothelial dysfunction.
C1 [Eldakhakhny, Basmah; Bima, Abdulhadi; Alamoudi, Aliaa A.; Alnami, Abrar; Almoghrabi, Yousef; Elsamanoudy, Ayman] King Abdulaziz Univ, Fac Med, Dept Clin Biochem, Jeddah, Saudi Arabia.
   [Eldakhakhny, Basmah; Elsamanoudy, Ayman] King Abdulaziz Univ, King Fahd Med Res Ctr, Food Nutr & Lifestyle Res Unit, Jeddah, Saudi Arabia.
   [Alamoudi, Aliaa A.; Almoghrabi, Yousef] King Abdulaziz Univ, King Fahd Med Res Ctr, Regenerat Med Unit, Jeddah, Saudi Arabia.
   [Abo-Elkhair, Salwa Mohamed; Elsamanoudy, Ayman] Mansoura Univ, Fac Med, Dept Med Biochem & Mol Biol, Mansoura, Egypt.
   [Sakr, Hussein] Sultan Qaboos Univ, Coll Med & Hlth Sci, Dept Physiol, Muscat, Oman.
   [Sakr, Hussein] Mansoura Univ, Fac Med, Dept Med Physiol, Mansoura, Egypt.
   [Ghoneim, Fatma Mohamed] Fakeeh Coll Med Sci, Dept Physiol Sci, MBBS Program, Jeddah, Saudi Arabia.
   [Ghoneim, Fatma Mohamed] Mansoura Univ, Fac Med, Dept Med Histol & Cell Biol, Mansoura, Egypt.
   [Nagib, Reham Mohamed] Mansoura Univ, Fac Med, Dept Anat Pathol, Mansoura, Egypt.
C3 King Abdulaziz University; King Abdulaziz University; King Abdulaziz
   University; Egyptian Knowledge Bank (EKB); Mansoura University; Sultan
   Qaboos University; Egyptian Knowledge Bank (EKB); Mansoura University;
   Fakeeh College for Medical Sciences; Egyptian Knowledge Bank (EKB);
   Mansoura University; Egyptian Knowledge Bank (EKB); Mansoura University
RP Elsamanoudy, A (corresponding author), King Abdulaziz Univ, Fac Med, Dept Clin Biochem, Jeddah, Saudi Arabia.; Elsamanoudy, A (corresponding author), King Abdulaziz Univ, King Fahd Med Res Ctr, Food Nutr & Lifestyle Res Unit, Jeddah, Saudi Arabia.; Elsamanoudy, A (corresponding author), Mansoura Univ, Fac Med, Dept Med Biochem & Mol Biol, Mansoura, Egypt.
EM azalsayd@kau.edu.sa
RI Elsamanoudy, Ayman/M-6529-2018; Sakr, Hussein/O-4888-2018; Almoghrabi,
   Yousef/MDS-6583-2025; Eldakhakhny, Basmah/ABD-6211-2020
OI Eldakhakhny, Basmah/0000-0002-6962-5848
FU Deanship of Scientific Research (DSR), King Abdulaziz University,
   Jeddah, Saudi Arabia [KEP-Msc-11-140-42]
FX The author(s) declare that financial support was received for the
   research, authorship, and/or publication of this article. This research
   was funded by The Deanship of Scientific Research (DSR), King Abdulaziz
   University, Jeddah, Saudi Arabia (KEP-Msc-11-140-42).
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NR 98
TC 0
Z9 0
U1 6
U2 6
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD NOV 13
PY 2024
VL 11
AR 1467719
DI 10.3389/fnut.2024.1467719
PG 15
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA N3D8Q
UT WOS:001363194000001
PM 39610878
OA gold
DA 2025-06-11
ER

PT J
AU Lin, LR
   Tan, W
   Pan, XF
   Tian, E
   Wu, ZF
   Yang, JR
AF Lin, Lirong
   Tan, Wei
   Pan, Xianfeng
   Tian, En
   Wu, Zhifeng
   Yang, Jurong
TI Metabolic Syndrome-Related Kidney Injury: A Review and Update
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Review
DE metabolic syndrome; chronic kidney disease; diagnosis; pathological
   characteristics; therapeutics
ID CELLS; METAANALYSIS; PREVALENCE; EXPRESSION; DISEASE; REPAIR; CHINA;
   RISK
AB Metabolic syndrome (MetS) includes visceral obesity, hyperglycemia, dyslipidemia, and hypertension. The prevalence of MetS is 20-25%, which is an important risk factor for chronic kidney disease (CKD). MetS causes effects on renal pathophysiology, including glomerular hyperfiltration, RAAS, microalbuminuria, profibrotic factors and podocyte injury. This review compares several criteria of MetS and analyzes their differences. MetS and the pathogenesis of CKD includes insulin resistance, obesity, dyslipidemia, inflammation, oxidative stress, and endothelial dysfunction. The intervention of MetS-related renal damage is the focus of this article and includes controlling body weight, hypertension, hyperglycemia, and hyperlipidemia, requiring all components to meet the criteria. In addition, interventions such as endoplasmic reticulum stress, oxidative stress, gut microbiota, body metabolism, appetite inhibition, podocyte apoptosis, and mesenchymal stem cells are reviewed.
C1 [Lin, Lirong; Tan, Wei; Tian, En; Wu, Zhifeng; Yang, Jurong] Chongqing Med Univ, Gener Hosp, Dept Nephrol, Affiliated Hosp 3, Chongqing, Peoples R China.
   [Pan, Xianfeng] Chongqing Kaizhou Dist Peoples Hosp Chongqing, Dept Nephrol, Chongqing, Peoples R China.
C3 Chongqing Medical University
RP Yang, JR (corresponding author), Chongqing Med Univ, Gener Hosp, Dept Nephrol, Affiliated Hosp 3, Chongqing, Peoples R China.
EM 650230@hospital.cqmu.edu.cn
RI Yang, Jurong/AGO-6020-2022; WU, ZHIFENG/GQI-0052-2022
FU National Natural Science Foundation of China [81770682]; Basic and
   Frontier Research Program of Chongqing [cstc2017jcyjBX0014]; Chongqing
   Talent Program Project [cstc2021ycjh-bgzxm0090]
FX This work was supported by the National Natural Science Foundation of
   China (No. 81770682), the Basic and Frontier Research Program of
   Chongqing (cstc2017jcyjBX0014) and the Chongqing Talent Program Project
   (cstc2021ycjh-bgzxm0090).
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NR 160
TC 61
Z9 62
U1 2
U2 15
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD JUN 23
PY 2022
VL 13
AR 904001
DI 10.3389/fendo.2022.904001
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 3B1PH
UT WOS:000827719700001
PM 35813613
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Park, H
   Shin, D
   Lee, KW
AF Park, Haeun
   Shin, Dayeon
   Lee, Kyung Won
TI Association of main meal frequency and skipping with metabolic syndrome
   in Korean adults: a cross-sectional study
SO NUTRITION JOURNAL
LA English
DT Article
DE Meal frequency; Meal skipping; Metabolic syndrome; Korean adults;
   KNHANES
ID CARDIOMETABOLIC RISK-FACTORS; EATING FREQUENCY; WEIGHT STATUS; BREAKFAST
   CONSUMPTION; CALORIC RESTRICTION; PHYSICAL-ACTIVITY; OXIDATIVE STRESS;
   BODY-WEIGHT; OBESITY; CHILDREN
AB BackgroundReduced meal frequency can increase the risk of metabolic syndrome (MetS). However, limited studies have examined the association between meal frequency and skipping meals with MetS. This study aims to analyze the association between main meal frequency and meal skipping with MetS in Korean adults aged >= 19 years.MethodsIn this study, we included data from 22,699 Korean adult participants from the 2016-2020 Korea National Health and Nutrition Examination Survey (KNHANES). The 24-h dietary recall method was used to classify the participants into three groups based on main meal frequency (one, two, or three meals per day) and seven groups based on the type of main meal they skipped. Multivariable logistic regression analysis was conducted to determine the association between main meal frequency and the types of main meals skipped with the odds of MetS and its associated components. Appropriate estimates were accounted for using sampling weights, stratification, and clustering.ResultsThe prevalence of MetS in the study population was 33.8%. The average age of the participants was 47.2 years with 42.6% being men, and 57.4% being women. Men who consumed two meals per day had higher odds of MetS than those who consumed three meals per day (odds ratio [OR] 1.16, 95% confidence interval [CI] 1.01-1.33). Women who consumed two meals per day, and skipped breakfast had increased odds of having elevated fasting blood glucose levels (OR 1.18, 95% CI 1.02-1.35), and elevated triglycerides (OR 1.19, 95% CI 1.02-1.39). However, women who skipped dinner had reduced odds of having elevated fasting blood glucose levels (OR 0.74, 95% CI 0.58-0.94).ConclusionsOur findings suggest that meal frequency and the type of main meal skipped may be associated with MetS and emphasize the importance of consuming breakfast to prevent MetS.
C1 [Park, Haeun; Shin, Dayeon] Inha Univ, Dept Food & Nutr, 100 Inha Ro, Incheon 22212, South Korea.
   [Lee, Kyung Won] Korea Natl Univ Educ, Dept Home Econ Educ, 250 Taeseongtabyeon Ro, Cheongju 28173, South Korea.
C3 Inha University; Korea National University of Education
RP Shin, D (corresponding author), Inha Univ, Dept Food & Nutr, 100 Inha Ro, Incheon 22212, South Korea.; Lee, KW (corresponding author), Korea Natl Univ Educ, Dept Home Econ Educ, 250 Taeseongtabyeon Ro, Cheongju 28173, South Korea.
EM dyshin@inha.ac.kr; kwlee@knue.ac.kr
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NR 62
TC 5
Z9 5
U1 2
U2 7
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1475-2891
J9 NUTR J
JI Nutr. J.
PD MAY 11
PY 2023
VL 22
IS 1
AR 24
DI 10.1186/s12937-023-00852-x
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA F9WY6
UT WOS:000985789400001
PM 37165359
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Kim, CJ
   Kang, HS
   Kim, JS
   Won, YY
   Schlenk, EA
AF Kim, Chun-Ja
   Kang, Hee Sun
   Kim, Jung Suk
   Won, Ye Yeon
   Schlenk, Elizabeth A.
TI Predicting physical activity and cardiovascular risk and quality of life
   in adults with osteoarthritis at risk for metabolic syndrome: A test of
   the information-motivation-behavioral skills model
SO NURSING OPEN
LA English
DT Article
DE cardiovascular diseases; depression; metabolic syndrome; osteoarthritis;
   physical activity; quality of life; self-efficacy; social support
ID MEDICATION ADHERENCE; SOCIAL SUPPORT; QUESTIONNAIRE; ASSOCIATION;
   DEPRESSION; CARE; AGE
AB Aim To examine a hypothetical model of physical activity and health outcomes (cardiovascular risk and quality of life) based on the information-motivation-behavioural skills model in adults.
   Design A cross-sectional survey.
   Methods A total of 165 adults with osteoarthritis at risk for metabolic syndrome were recruited between October 2016 and September 2017 from the outpatient clinic in South Korea. Data were collected on the model constructs such as cognitive function, social support, depressive symptoms, barriers to self-efficacy, physical activity and quality of life. A hypothetical model was tested using the AMOS 25.0 program.
   Results Cognitive function and barriers to self-efficacy had a direct effect on physical activity. Physical activity had a direct effect on cardiovascular risk, while social support and depressive symptoms had a direct effect on quality of life.
   Conclusions The information-motivation-behavioural skills model can predict physical activity and, in turn, cardiovascular risk and quality of life in adults with osteoarthritis at risk for metabolic syndrome.
C1 [Kim, Chun-Ja; Kim, Jung Suk] Ajou Univ, Coll Nursing, Suwon, South Korea.
   [Kim, Chun-Ja; Kim, Jung Suk] Ajou Univ, Res Inst Nursing Sci, Suwon, South Korea.
   [Kang, Hee Sun] Chung Ang Univ, Red Cross Coll Nursing, 84 Heukseok Ro, Seoul 06974, South Korea.
   [Won, Ye Yeon] Ajou Univ, Sch Med, Dept Orthoped Surg, Suwon, South Korea.
   [Won, Ye Yeon] Ajou Univ, Grad Sch Med, Suwon, South Korea.
   [Schlenk, Elizabeth A.] Univ Pittsburgh, Sch Nursing, Pittsburgh, PA 15261 USA.
C3 Ajou University; Ajou University; Chung Ang University; Ajou University;
   Ajou University; Pennsylvania Commonwealth System of Higher Education
   (PCSHE); University of Pittsburgh
RP Kang, HS (corresponding author), Chung Ang Univ, Red Cross Coll Nursing, 84 Heukseok Ro, Seoul 06974, South Korea.
EM goodcare@cau.ac.kr
RI Kang, Hee/AAG-9381-2019; Kim, Chun-Ja/HKF-2429-2023; Won, Ye
   Yeon/JXL-2993-2024; KIM, JUNG SUK/IAL-8910-2023
OI Kang, Hee Sun/0000-0003-3808-306X; Won, Seok-Hyung/0000-0002-1880-4336;
   KIM, Chun-Ja/0000-0002-7594-5418; Schlenk, Elizabeth/0000-0001-7361-1951
FU Department of Nursing Science, Graduate School, Ajou University
   [M-2016-00014]
FX This work was supported by a 2016 research grant from the Department of
   Nursing Science, Graduate School, Ajou University to CK. Grant no.
   (M-2016-00014).
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NR 53
TC 10
Z9 10
U1 2
U2 17
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 2054-1058
J9 NURS OPEN
JI NURS. OPEN
PD JUL
PY 2020
VL 7
IS 4
BP 1239
EP 1248
DI 10.1002/nop2.500
EA MAY 2020
PG 10
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA MA2TP
UT WOS:000532546100001
PM 32587744
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Chen, Y
   Petzold, M
   Rüetschi, U
   Dahlstrand, J
   Löfstedt, P
   Corell, M
   Friberg, P
AF Chen, Yun
   Petzold, Max
   Ruetschi, Ulrika
   Dahlstrand, Johan
   Lofstedt, Petra
   Corell, Maria
   Friberg, Peter
TI Hair glucocorticoid concentration, self-perceived stress and their
   associations with cardiometabolic risk markers in Swedish adolescents
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE Perceived stress; Hair glucocorticoids; Coping strategies; Body mass
   index; Waist circumference; White blood cell counts; Blood pressure;
   Adolescent
ID BODY-MASS INDEX; CORTISOL CONCENTRATIONS
AB Background: While hair cortisol is proposed as a biomarker for chronic stress and a possible mediator linking chronic stress and cardiovascular risk in adults, studies in adolescents are scarce. We explored the associations between self-perceived stress, hair cortisol (HairF) and cortisone (HairE), and cardiometabolic risk markers in adolescents. Further, we examined whether association between self-perceived stress and HairF may depend on the use of the coping strategies "shift-persist ". Methods: Participants were 7th grade pupils recruited to the STudy of Adolescence Resilience and Stress (STARS) and data from the baseline examinations were used. Adolescents (n = 1553, 26 % boys, Mage=13.6, SD = 0.4) completed questionnaires assessing perceived stress and coping strategies "shift-persist ", provided hair sample, and examined for cardiometabolic risk factors including waist circumference (WC), body mass index (BMI) z -score, blood pressure, and white blood cell counts (WBC). HairF and HairE were analysed using liquid chro-matography with tandem mass spectrometry. We conducted descriptive analyses (Student's t-test, Wilcoxon Signed Ranks test, Chi-square test) and linear regression analyses. Results: Perceived stress was not associated with HairF, neither had the use of coping strategies "shift-persist " any influence on this association. Both HairF and HairE were positively associated with BMI z-score (beta coefficients (8): 0.178 (p < 0.001) and 0.119 (p < 0.001) for boys; 0.123 (p < 0.001) and 0.089 (p < 0.01) for girls) and WC (8: 0.089 (p > 0.05) and 0.098 (p < 0.05) for boys; 0.103 (p < 0.01) and 0.076 (p < 0.05) for girls). Perceived stress was also positively associated with BMI z-score and WC. Perceived stress, but not HairF, remained asso-ciated with WC in boys (8 = 0.200, p < 0.001) in the models with HairF and perceived stress presented simultaneously. Modest association between HairE and WBC was found in boys (8 = 0.149, p < 0.01). Conclusions: The study supports the association between chronic stress and overweight/obesity in adolescents. Hair cortisol and self-perceived stress capture different aspects of how chronic stress is related to overweight/ obesity in adolescents.
C1 [Chen, Yun; Petzold, Max; Dahlstrand, Johan; Lofstedt, Petra; Corell, Maria; Friberg, Peter] Univ Gothenburg, Sahlgrenska Acad, Sch Publ Hlth & Community Med, Gothenburg, Sweden.
   [Ruetschi, Ulrika] Sahlgrens Univ Hosp, Dept Clinial Chem, Gothenburg, Sweden.
C3 University of Gothenburg; Sahlgrenska University Hospital
RP Chen, Y (corresponding author), Univ Gothenburg, Sch Publ Hlth & Community Med, Box 453, S-40530 Gothenburg, Sweden.
EM yun.chen@gu.se; max.petzold@gu.se; ulrika.ruetschi@vgregion.se;
   johan.dahlstrand@gu.se; petra.lofstedt@folkhalsomyndigheten.se;
   maria.corell@folkhalsomyndigheten.se; peter.friberg@gu.se
OI Chen, Yun/0000-0002-3746-594X
FU Swedish Research Council [2014-10086]; Swedish Government; country
   councils [239371]; Public Health Agency of Sweden; Region Vastra
   Gotaland; Gothenburg University; Carl Bennet AB; Swedish Research
   Council [2014-10086] Funding Source: Swedish Research Council
FX The study was funded by Swedish Research Council (Project number:
   2014-10086) , the Swedish state under the agreement between the Swedish
   Government and the country councils (the ALF-agreement, Project number:
   239371) , Region Vastra Gotaland, Gothenburg University, Carl Bennet AB
   and the Public Health Agency of Sweden. The funders of the study had no
   role in study design, data collection, data analysis, data
   interpretation, or writing of the report.
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NR 35
TC 6
Z9 6
U1 0
U2 10
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
EI 1873-3360
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD DEC
PY 2022
VL 146
AR 105908
DI 10.1016/j.psyneuen.2022.105908
EA AUG 2022
PG 7
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA 5A3WU
UT WOS:000862821100002
PM 36054941
OA hybrid
DA 2025-06-11
ER

PT J
AU Christian, P
   Su, QZ
AF Christian, Patricia
   Su, Qiaozhu
TI MicroRNA regulation of mitochondrial and ER stress signaling pathways:
   implications for lipoprotein metabolism in metabolic syndrome
SO AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
LA English
DT Review
DE microRNAs; fatty acid metabolism; ER stress; inflammation; lipoprotein
   metabolism
ID ENDOPLASMIC-RETICULUM STRESS; HIGH-DENSITY-LIPOPROTEIN; REVERSE
   CHOLESTEROL TRANSPORT; TRIGLYCERIDE TRANSFER PROTEIN;
   NECROSIS-FACTOR-ALPHA; NLRP3 INFLAMMASOME; TRANSCRIPTIONAL ACTIVATION;
   TYROSINE PHOSPHORYLATION; SCAVENGER RECEPTOR; MIRNA-ASTERISK
AB The development of metabolic syndrome is closely associated with the deregulation of lipid metabolism. Emerging evidence has demonstrated that microRNAs (miRNAs) are intensively engaged in lipid and lipoprotein metabolism by regulating genes involved in control of intracellular lipid synthesis, mitochondrial fatty acid oxidation, and lipoprotein assembly. Mitochondrial dysfunction induced by altered miRNA expression has been proposed to be a contributing factor in the onset of metabolic diseases, while at the same time, aberrant expression of certain miRNAs is associated with the induction of endoplasmic reticulum (ER) stress induced by nutrient-surplus. These studies position miRNAs as a link between oxidative stress and ER stress, two cellular stress pathways that are deregulated in metabolic disease and are associated with very-low-density lipoprotein (VLDL) overproduction. Dyslipoproteinemia frequently accompanied with metabolic syndrome is initiated largely by the overproduction of VLDL and altered biogenesis of high-density lipoprotein (HDL). In this review, we highlight recent findings on the regulatory impact of miRNAs on the metabolic homeostasis of mitochondria and ER as well as their contribution to the aberrant biogenesis of both VLDL and HDL in the context of metabolic disorders, in an attempt to gain further insights into the molecular mechanisms of dyslipidemia in the metabolic syndrome.
C1 [Christian, Patricia; Su, Qiaozhu] Univ Nebraska, Dept Nutr & Hlth Sci, Lincoln, NE 68583 USA.
C3 University of Nebraska System; University of Nebraska Lincoln
RP Su, QZ (corresponding author), Univ Nebraska, 316F Leverton Hall, Lincoln, NE 68583 USA.
EM qsu2@unl.edu
OI Su, Qiaozhu/0000-0001-8434-1408
FU ARD Hatch Grant; University of Nebraska-Lincoln
FX This work was supported by an ARD Hatch Grant and a Faculty Seed Grant
   Award from the University of Nebraska-Lincoln to Q. Su.
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NR 99
TC 40
Z9 42
U1 0
U2 28
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0193-1849
EI 1522-1555
J9 AM J PHYSIOL-ENDOC M
JI Am. J. Physiol.-Endocrinol. Metab.
PD NOV 1
PY 2014
VL 307
IS 9
BP E729
EP E737
DI 10.1152/ajpendo.00194.2014
PG 9
WC Endocrinology & Metabolism; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Physiology
GA AT5NK
UT WOS:000344989400001
PM 25184990
DA 2025-06-11
ER

PT J
AU Potz, BA
   Scrimgeour, LA
   Sabe, SA
   Clements, RT
   Sodha, NR
   Sellke, FW
AF Potz, Brittany A.
   Scrimgeour, Laura A.
   Sabe, Sharif A.
   Clements, Richard T.
   Sodha, Neel R.
   Sellke, Frank W.
TI Glycogen synthase kinase 3β inhibition reduces mitochondrial oxidative
   stress in chronic myocardial ischemia
SO JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
LA English
DT Article; Proceedings Paper
CT 43rd Annual Meeting of the Western-Thoracic-Surgical-Association
CY JUN 21-24, 2017
CL Colorado Springs, CO
SP Western Thorac Surg Assoc
DE metabolic syndrome; chronic coronary ischemia; glycogen synthase kinase
   3B; oxidative stress; collagen
ID CARDIAC FIBROSIS; CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME;
   REPERFUSION; CARDIOPROTECTION; PHOSPHORYLATION; KINASE-3-BETA;
   DYSFUNCTION; GSK-3-BETA; APOPTOSIS
AB Objectives: Glycogen synthase kinase 3 beta (GSK-3 beta) inhibition has been reported to increase microvascular density and improve myocardial blood flow in a porcine model of chronic myocardial ischemia and metabolic syndrome. Inhibition of GSK-3 beta can also be cardioprotective by modulating fibrosis signaling and mitochondrial-induced apoptosis. We hypothesized GSK-3 beta inhibition would have a beneficial effect on myocardial fibrosis and oxidative stress in a porcine model of chronic myocardial ischemia and metabolic syndrome.
   Methods: Pigs were fed a high fat diet for 4 weeks followed by placement of an ameroid constrictor to the left circumflex coronary artery. Three weeks later animals received either no drug or a GSK-3 beta inhibitor. The diets and placebo/GSK-3 beta inhibition were continued for an additional 5 weeks, the pigs were then euthanized, and the myocardial tissue was harvested. Collagen expression was analyzed via Picrosirius staining. Oxidative stress was analyzed via Oxyblot analysis. Protein expression was analyzed via Western blot.
   Results: GSK-3 beta inhibition was associated with decreased collagen expression and oxidative stress in the ischemic and nonischemic myocardial tissue compared with control. There was a decrease in profibrotic proteins transforming growth factor-beta, p-SMAD2/3, and matrix metalloproteinase-9, and in proapoptotic and oxidative stress proteins, apoptosis inducing factor, the cleaved caspase 3/caspase 3 protein ratio and phosphorylated myeloid cell leukemia sequence-1 in the GSK-3 beta inhibited group compared with the control.
   Conclusions: In the setting of metabolic syndrome and chronic myocardial ischemia, inhibition of GSK-3 beta decreases collagen formation and oxidative stress in myocardial tissue. GSK-3 beta inhibition might be having this beneficial effect by downregulating transforming growth factor-beta/SMAD2/3 signaling and decreasing mitochondrial induced cellular stress.
C1 [Potz, Brittany A.; Scrimgeour, Laura A.; Sabe, Sharif A.; Clements, Richard T.; Sodha, Neel R.; Sellke, Frank W.] Brown Univ, Rhode Isl Hosp, Dept Surg, Div Cardiothorac Surg,Cardiovasc Res Ctr,Alpert M, Providence, RI 02903 USA.
C3 Brown University; Lifespan Health Rhode Island; Rhode Island Hospital
RP Sellke, FW (corresponding author), Div Cardiothorac Surg, 2 Dudley St,MOC 360, Providence, RI 02905 USA.
EM fsellke@lifespan.org
FU National Heart, Lung, and Blood Institute [RO1HL128831, RO1 HL46716];
   NIH [T32 GM065085]; National Institutes of Health/National Institute of
   General Medical Sciences [2T32 GM065085]; American Heart Association
   [GRNT20460376]; National Institute of General Medical Sciences
   [U54GM115677]
FX Funding for this research was provided by the National Heart, Lung, and
   Blood Institute (RO1HL128831, RO1 HL46716) (to F.W. Sellke); NIH T32
   GM065085 training grant to (to L.A. Scrimgeour); and National Institutes
   of Health/National Institute of General Medical Sciences training grant
   2T32 GM065085 to (to B.A. Potz); American Heart Association Grant-in-Aid
   GRNT20460376, and National Institute of General Medical Sciences
   U54GM115677 (to R.T. Clements).
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NR 36
TC 17
Z9 19
U1 0
U2 15
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0022-5223
EI 1097-685X
J9 J THORAC CARDIOV SUR
JI J. Thorac. Cardiovasc. Surg.
PD JUN
PY 2018
VL 155
IS 6
BP 2492
EP 2501
DI 10.1016/j.jtcvs.2017.12.127
PG 10
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA GG0LG
UT WOS:000432369400067
PM 29523407
OA Bronze, Green Accepted
DA 2025-06-11
ER

PT J
AU Michels, N
   Matthys, D
   Thumann, B
   Marild, S
   De Henauw, S
AF Michels, Nathalie
   Matthys, Dante
   Thumann, Barbara
   Marild, Staffan
   De Henauw, Stefaan
TI Children's stress-related reports and stress biomarkers interact in
   their association with metabolic syndrome risk
SO STRESS AND HEALTH
LA English
DT Article
DE autonomic nervous system; cardiovascular disease prevention; cortisol;
   metabolic health; moderation; psychophysiology; psychosocial stress
ID PITUITARY-ADRENAL AXIS; HEART-RATE-VARIABILITY; BODY-MASS INDEX;
   SALIVARY CORTISOL; HYPERCORTISOLEMIC DEPRESSION; PHYSICAL-ACTIVITY;
   SERUM CORTISOL; BLOOD-PRESSURE; COMPONENTS; CHILDHOOD
AB The purpose was to examine the cross-sectional associations of stress-related reports and stress biomarkers with metabolic syndrome (MetS) risk in children while also testing the interaction between stress biomarkers and stress reports. In 353 children (5-10years old, 7.9% overweight/obese), MetS risk was measured by blood pressure, waist circumference, glucose homeostasis, triglycerides, and high-density cholesterol. Stress was measured by stress-related reports (events, emotions, and internalizing/externalizing problems) and two biomarkers: salivary cortisol (total-day and morning output) and heart rate variability (percentage of consecutive normal RR intervals differing more than 50ms and low-to-high-frequency ratio). Cross-sectional regression analyses with z scored total MetS risk as outcome were adjusted for age, sex, and socio-economic status. Only internalizing problems were directly related to a higher MetS risk score (=0.236). Cortisol and heart rate variability were significant moderators: High cortisol morning output resulted in a positive (unfavourable) report-MetS relationship (=0.259-0.552), whereas low percentage of consecutive normal RR intervals differing more than 50ms resulted in a negative (favourable) report-MetS relationship (=-0.298) and low low-to-high-frequency ratio in a positive (unfavourable) report-MetS relationship (=0.478). In conclusion, stress can sometimes be a disadvantageous factor in metabolic health of otherwise healthy children. The cortisol biomarker seems relevant because metabolic risk was highest when stress-related reports were accompanied by high morning cortisol output.
C1 [Michels, Nathalie; Matthys, Dante; De Henauw, Stefaan] Univ Ghent, Fac Med & Hlth Sci, Dept Publ Hlth, Ghent, Belgium.
   [Thumann, Barbara] BIPS, Leibniz Inst Prevent Res & Epidemiol, Dept Epidemiol Methods & Etiol Res, Bremen, Germany.
   [Marild, Staffan] Univ Gothenburg, Sahlgrenska Acad, Queen Silvia Childrens Hosp, Dept Pediat,Inst Clin Sci, Gothenburg, Sweden.
C3 Ghent University; Leibniz Association; Leibniz Institute for Prevention
   Research & Epidemiology (BIPS); University of Gothenburg; Queen Silvia
   Children's Hospital
RP Michels, N (corresponding author), Univ Ghent, Pintelaan 185,4K3, B-9000 Ghent, Belgium.
EM nathalie.michels@ugent.be
RI Michels, Nathalie/C-2819-2012
OI Michels, Nathalie/0000-0002-3069-7254
FU Ghent University [016181]; Research Foundation-Flanders
   [FWO.3E0.2015.0043.01]
FX Ghent University, Grant/Award Number: 016181; Research
   Foundation-Flanders, Grant/Award Number: FWO.3E0.2015.0043.01
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NR 63
TC 3
Z9 3
U1 0
U2 18
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1532-3005
EI 1532-2998
J9 STRESS HEALTH
JI Stress Health
PD OCT
PY 2018
VL 34
IS 4
BP 523
EP 533
DI 10.1002/smi.2813
PG 11
WC Psychology, Applied; Psychiatry; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA GW9MC
UT WOS:000447311100005
PM 29733496
DA 2025-06-11
ER

PT J
AU Sirmans, SM
   Pate, KA
AF Sirmans, Susan M.
   Pate, Kristen A.
TI Epidemiology, diagnosis, and management of polycystic ovary syndrome
SO CLINICAL EPIDEMIOLOGY
LA English
DT Review
DE polycystic ovary syndrome; diagnosis; comorbidities; epidemiology;
   management; comorbidities; women's health; hyperandrogenism
ID IMPAIRED GLUCOSE-TOLERANCE; CLOMIPHENE CITRATE INDUCTION; OVULATION
   INDUCTION; INSULIN-RESISTANCE; SYNDROME PCOS; ANDROGEN EXCESS;
   RISK-FACTORS; FOLLOW-UP; CAROTID ATHEROSCLEROSIS; CARDIOVASCULAR-DISEASE
AB Polycystic ovary syndrome (PCOS) is a common heterogeneous endocrine disorder characterized by irregular menses, hyperandrogenism, and polycystic ovaries. The prevalence of PCOS varies depending on which criteria are used to make the diagnosis, but is as high as 15%-20% when the European Society for Human Reproduction and Embryology/American Society for Reproductive Medicine criteria are used. Clinical manifestations include oligomenorrhea or amenorrhea, hirsutism, and frequently infertility. Risk factors for PCOS in adults includes type 1 diabetes, type 2 diabetes, and gestational diabetes. Insulin resistance affects 50%-70% of women with PCOS leading to a number of comorbidities including metabolic syndrome, hypertension, dyslipidemia, glucose intolerance, and diabetes. Studies show that women with PCOS are more likely to have increased coronary artery calcium scores and increased carotid intima-media thickness. Mental health disorders including depression, anxiety, bipolar disorder and binge eating disorder also occur more frequently in women with PCOS. Weight loss improves menstrual irregularities, symptoms of androgen excess, and infertility. Management of clinical manifestations of PCOS includes oral contraceptives for menstrual irregularities and hirsutism. Spironolactone and finasteride are used to treat symptoms of androgen excess. Treatment options for infertility include clomiphene, laparoscopic ovarian drilling, gonadotropins, and assisted reproductive technology. Recent data suggest that letrozole and metformin may play an important role in ovulation induction. Proper diagnosis and management of PCOS is essential to address patient concerns but also to prevent future metabolic, endocrine, psychiatric, and cardiovascular complications.
C1 [Sirmans, Susan M.; Pate, Kristen A.] Univ Louisiana Monroe, Dept Clin & Adm Sci, Coll Pharm, Monroe, LA USA.
C3 University of Louisiana System; University of Louisiana Monroe
RP Sirmans, SM (corresponding author), Univ Louisiana Monroe, Coll Pharm, Baton Rouge Campus,3849 North Blvd, Baton Rouge, LA 70806 USA.
EM sirmans@ulm.edu
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NR 147
TC 665
Z9 731
U1 10
U2 196
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1179-1349
J9 CLIN EPIDEMIOL
JI Clin. Epidemiol.
PY 2014
VL 6
BP 1
EP 13
DI 10.2147/CLEP.S37559
PG 13
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA V46NL
UT WOS:000209890800001
PM 24379699
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Thompson, JA
   Regnault, TRH
AF Thompson, Jennifer A.
   Regnault, Timothy R. H.
TI In Utero Origins of Adult Insulin Resistance and Vascular Dysfunction
SO SEMINARS IN REPRODUCTIVE MEDICINE
LA English
DT Article
DE Fetus; programming; adult; muscle; insulin resistance; vessels; vascular
   dysfunction; endothelial dysfunction
ID ACTIVATED-RECEPTOR-DELTA; INTIMA-MEDIA THICKNESS; HUMAN SKELETAL-MUSCLE;
   LOW-BIRTH-WEIGHT; FATTY-ACID OXIDATION; INTRAUTERINE GROWTH-RETARDATION;
   CATCH-UP GROWTH; CARNITINE PALMITOYLTRANSFERASE-I; MATERNAL NUTRIENT
   RESTRICTION; DIETARY-PROTEIN RESTRICTION
AB The metabolic syndrome (or syndrome X) is a constellation of risk factors including insulin resistance, hypertension, dyslipidemia, and central obesity that predispose to the development of cardiovascular disease and type 2 diabetes in adult life. Insulin resistance is believed to be a critical pathophysiological event early in the disease process, impacting both skeletal muscle metabolic function and vascular responses. Adverse changes in insulin sensitivity have been found to originate in utero; for instance, prenatal events such as placental insufficiency/oxidative stress leading to altered fetal growth trajectories are associated with increased rates of metabolic syndrome in adult life. Such intrauterine insults result in reduced skeletal muscle mass in conjunction with altered insulin signaling, decreased oxidative fibers, and impaired mitochondrial function. These developmental disturbances set the stage for development of muscle triglyceride accumulation and depressed insulin sensitivity in childhood. Abnormalities of vascular structure and function arising from deprived intrauterine conditions that are exacerbated by insulin resistance account for the progression of hypertension from childhood to adulthood. Arterial changes initiated in utero include reduced endothelial nitric oxide (NO) bioavailability, vascular smooth muscle cell proliferation and inflammation, events leading to endothelial dysfunction, and atherosclerosis that are present in those destined for metabolic syndrome. In addition, the hypertensive phenotype that is a hallmark of metabolic syndrome may also be traced to blunted kidney development and renin-angiotensin system activation in growth-restricted offspring. The summative impact of these intrauterine programmed changes in terms of influencing adult health and disease encompasses dietary and lifestyle factors introduced postnatally. Establishing novel therapeutic interventions aimed at preventing and/or reducing in utero induced insulin resistance and vascular dysfunction warrants investigation because the numbers of low birthweight babies continue to increase.
C1 [Thompson, Jennifer A.; Regnault, Timothy R. H.] Univ Western Ontario, Dept Obstet & Gynaecol, Childrens Hlth Res Inst, London, ON N6A 5C1, Canada.
   [Thompson, Jennifer A.; Regnault, Timothy R. H.] Univ Western Ontario, Dept Physiol & Pharmacol, Childrens Hlth Res Inst, London, ON N6A 5C1, Canada.
   [Thompson, Jennifer A.; Regnault, Timothy R. H.] Univ Western Ontario, Lawson Res Inst, London, ON N6A 5C1, Canada.
C3 Western University (University of Western Ontario); Western University
   (University of Western Ontario); Western University (University of
   Western Ontario); University Western Ontario Hospital
RP Regnault, TRH (corresponding author), Univ Western Ontario, Dept Obstet & Gynaecol, Childrens Hlth Res Inst, London, ON N6A 5C1, Canada.
EM tim.regnault@uwo.ca
RI Regnault, Timothy/J-8902-2014
OI Regnault, Timothy/0000-0003-1930-8358; Thompson,
   Jennifer/0000-0003-0421-3719
FU Natural Sciences and Engineering Research Council of Canada, Canadian
   Institutes of Health Research
FX We are supported by the Natural Sciences and Engineering Research
   Council of Canada, Canadian Institutes of Health Research.
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NR 182
TC 37
Z9 40
U1 1
U2 14
PU THIEME MEDICAL PUBL INC
PI NEW YORK
PA 333 SEVENTH AVE, NEW YORK, NY 10001 USA
SN 1526-8004
EI 1526-4564
J9 SEMIN REPROD MED
JI Semin. Reprod. Med.
PD MAY
PY 2011
VL 29
IS 3
BP 211
EP 224
DI 10.1055/s-0031-1275522
PG 14
WC Obstetrics & Gynecology; Reproductive Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology; Reproductive Biology
GA 755TY
UT WOS:000289961300006
PM 21710397
DA 2025-06-11
ER

PT J
AU Hsu, JY
   Lin, HH
   Wang, ZH
   Chen, JH
AF Hsu, Jen-Ying
   Lin, Hui-Hsuan
   Wang, Zhi-Hong
   Chen, Jing-Hsien
TI Aqueous extract from Pepino (Solanum muricatumAit.) leaves
   ameliorated insulin resistance, hyperlipidemia, and hyperglycemia in
   mice with metabolic syndrome
SO JOURNAL OF FOOD BIOCHEMISTRY
LA English
DT Article
DE antioxidant effect; aqueous extract from pepino leaf; hyperglycemia;
   hyperlipidemia; insulin resistance
ID ANTIOXIDANT ACTIVITY; OXIDATIVE STRESS; OBESITY; METFORMIN; GLUCOSE;
   HYPERINSULINEMIA; STEATOHEPATITIS; CHOLESTEROL; HOMEOSTASIS; PREVENTION
AB Solanum muricatum Ait. (Pepino) is a plant food commonly cultivated in the Penghu Island, Taiwan. This present study aimed to investigate the protective effects of aqueous extract of Pepino leaves (AEPL) in mice with metabolic syndrome. Metabolic syndrome animal model was induced by continuous high-fat diet feeding and low-dose streptozotocin (40 mg/ml) for 5 days. A 1% AEPL or metformin were given for 6 weeks after streptozotocin injection. The results revealed that 1% AEPL effectively reduced fasting blood glucose, insulin resistance, and hyperlipidemia in metabolic syndrome mice. Histologic examination revealed lipid accumulation in liver decreased by 1% AEPL treatment. Further, western blot analysis revealed 1% AEPL treatment managed enzymes related to lipid synthesis and oxidation pathways and hepatic glucose production. Besides, 1% AEPL treatment increased liver antioxidant activities to against oxidative stress. These results concluded that AEPL treatment attenuated insulin resistance, hyperlipidemia, and hyperglycemia of metabolic syndrome. Practical applications Metabolic syndrome (MS) is a multifactorial chronic disease which is characterized by dyslipidemia, insulin resistance, and hyperglycemia. However, there is no single drug or defined medication for MS so far. The present study revealed that AEPL treatment was able to regulate lipid metabolism and glycemic control at the molecular level to alleviate MS. AEPL has the potential to be a novo complementary medication for metabolic syndrome.
C1 [Hsu, Jen-Ying; Chen, Jing-Hsien] Chung Shan Med Univ, Dept Nutr, 110,Sec 1,Jianguo N Rd, Taichung 40201, Taiwan.
   [Lin, Hui-Hsuan] Chung Shan Med Univ, Dept Med Lab & Biotechnol, Taichung, Taiwan.
   [Wang, Zhi-Hong] Asia Univ, Dept Food Nutr & Hlth Biotechnol, Taichung, Taiwan.
   [Chen, Jing-Hsien] Chung Shan Med Univ Hosp, Dept Med Res, Taichung, Taiwan.
C3 Chung Shan Medical University; Chung Shan Medical University; Asia
   University Taiwan; Chung Shan Medical University; Chung Shan Medical
   University Hospital
RP Chen, JH (corresponding author), Chung Shan Med Univ, Dept Nutr, 110,Sec 1,Jianguo N Rd, Taichung 40201, Taiwan.
EM cjh0828@csmu.edu.tw
RI Wang, Zhihong/H-5327-2013
OI Chen, Jing-Hsien/0000-0001-5756-5959; /0000-0001-5232-8428
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NR 48
TC 5
Z9 5
U1 0
U2 10
PU WILEY-HINDAWI
PI LONDON
PA ADAM HOUSE, 3RD FL, 1 FITZROY SQ, LONDON, WIT 5HE, ENGLAND
SN 0145-8884
EI 1745-4514
J9 J FOOD BIOCHEM
JI J. Food Biochem.
PD DEC
PY 2020
VL 44
IS 12
AR e13518
DI 10.1111/jfbc.13518
EA OCT 2020
PG 13
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA PM2UE
UT WOS:000578696200001
PM 33047354
OA gold
DA 2025-06-11
ER

PT J
AU Ando, K
   Fujita, T
AF Ando, Katsuyuki
   Fujita, Toshiro
TI Metabolic syndrome and oxidative stress
SO FREE RADICAL BIOLOGY AND MEDICINE
LA English
DT Article; Proceedings Paper
CT 16th Annual Meeting of the Society-for-Free-Radical-Biology-and-Medicine
CY NOV 18-22, 2009
CL San Francisco, CA
SP Soc Free Rad Biol & Med
DE Reactive oxygen species; Insulin resistance; Salt sensitivity of blood
   pressure; Mineralocorticoid receptor; Sympathetic nerve activity; Free
   radicals
ID SALT-SENSITIVE HYPERTENSION; VENTRICULAR DIASTOLIC DYSFUNCTION; BRAIN
   MINERALOCORTICOID RECEPTOR; ARTERIAL-PRESSURE ELEVATION;
   SYMPATHETIC-NERVOUS-SYSTEM; INDUCED INSULIN-RESISTANCE; VITAMIN-C
   SUPPLEMENTATION; BLOOD-PRESSURE; RAT MODEL; SODIUM SENSITIVITY
AB Metabolic syndrome is an obesity-associated collection of disorders, each of which contributes to cardiovascular risk. Metabolic syndrome is also associated with overproduction of reactive oxygen species (ROS). ROS contribute to the interrelationship between metabolic syndrome and salt-sensitive hypertension. which are both caused by obesity and excess salt consumption and are major threats to health in developed Countries. ROS can induce insulin resistance, which is indispensable for the progression of metabolic syndrome, and salt-sensitive hypertension stimulates ROS production, thereby promoting the development of metabolic syndrome. Moreover, ROS activate mineralocorticoid receptors (MRs) and the sympathetic nervous system, which Can contribute to the development of metabolic syndrome and salt-sensitive hypertension. Salt-induced progression of cardiovascular disease (CVD) is also accelerated in animal models with metabolic syndrome, probably owing to further stimulation of ROS overproduction and subsequent ROS-induced MR activation and sympathetic excitation. Therefore, ROS contribute to the progression of the metabolic syndrome itself and to the CVD accompanying it, particularly in conjunction with excessive salt Consumption. Crown Copyright (C) 2009 Published by Elsevier Inc. All rights reserved.
C1 [Ando, Katsuyuki; Fujita, Toshiro] Univ Tokyo, Grad Sch Med, Dept Nephrol & Endocrinol, Tokyo 1138655, Japan.
C3 University of Tokyo
RP Fujita, T (corresponding author), Univ Tokyo, Grad Sch Med, Dept Nephrol & Endocrinol, Tokyo 1138655, Japan.
EM fujita-dis@h.u-tokyo.ac.jp
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NR 83
TC 128
Z9 140
U1 1
U2 12
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0891-5849
EI 1873-4596
J9 FREE RADICAL BIO MED
JI Free Radic. Biol. Med.
PD AUG 1
PY 2009
VL 47
IS 3
BP 213
EP 218
DI 10.1016/j.freeradbiomed.2009.04.030
PG 6
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 464UI
UT WOS:000267532800002
PM 19409982
DA 2025-06-11
ER

PT J
AU Pham, DQ
   Ommerborn, MJ
   Hickson, DA
   Taylor, HA
   Clark, CR
AF Do Quyen Pham
   Ommerborn, Mark J.
   Hickson, DeMarc A.
   Taylor, Herman A.
   Clark, Cheryl R.
TI Neighborhood Safety and Adipose Tissue Distribution in African
   Americans: The Jackson Heart Study
SO PLOS ONE
LA English
DT Article
ID CARDIOMETABOLIC RISK-FACTORS; PHYSICAL-ACTIVITY; OBESITY; ASSOCIATIONS;
   STRESS; CORTISOL; ADULTS; PATHOPHYSIOLOGY; GENDER; WOMEN
AB Objective: Patterns of fat distribution are heavily influenced by psychological stress, sex, and among women, by menopause status. Emerging evidence suggests the lack of perceived neighborhood safety due to crime may contribute to psychological stress and obesity among exposed residents. Our objective is to determine if perceived neighborhood safety is associated with abdominal adiposity among African-American men and women, and among pre-and postmenopausal women in the Jackson Heart Study.
   Design and Methods: We examined associations between perceived neighborhood safety, fat distribution, and other individual-level covariates among Jackson Heart Study participants (N = 2,881). Abdominal adiposity was measured via computed tomography scans measuring the volumes of visceral, subcutaneous and total adipose tissue. We also measured body mass index (BMI), and waist circumference. Multivariable regression models estimated associations between perceived neighborhood safety, adiposity, and covariates by sex and menopause status.
   Results: Adjusting for all covariates, women who strongly disagreed their neighborhood was safe from crime had a higher BMI compared to women who felt safe [Std B 0.083 95% CI (0.010, 0.156)]. Premenopausal women who felt most unsafe had higher BMI, waist circumference, and volumes of visceral and total adipose tissue than those who felt safe [Std B 0.160 (0.021, 0.299), Std B 0.142 (0.003, 0.280), Std B 0.150 (0.014, 0.285), Std B 0.154 (0.019, 0.290), respectively]. We did not identify associations between neighborhood safety and adiposity among men and postmenopausal women.
   Conclusions: Our data suggest that abdominal adipose tissue distribution patterns are associated with perceived neighborhood safety in some groups, and that patterns may differ by sex and menopause status, with most associations observed among pre-menopausal women. Further research is needed to elucidate whether there are causal mechanisms underlying sex and menopause-status differences that may mediate associations between perceived safety and abdominal adiposity and potential protective factors that may modify this risk.
C1 [Do Quyen Pham; Ommerborn, Mark J.; Clark, Cheryl R.] Brigham & Womens Hosp, Ctr Community Hlth & Hlth Equ, Boston, MA 02115 USA.
   [Hickson, DeMarc A.; Taylor, Herman A.] Univ Mississippi, Med Ctr, Dept Med, Jackson, MS 39216 USA.
C3 Harvard University; Harvard University Medical Affiliates; Brigham &
   Women's Hospital; University of Mississippi Medical Center; University
   of Mississippi
RP Clark, CR (corresponding author), Brigham & Womens Hosp, Ctr Community Hlth & Hlth Equ, 75 Francis St, Boston, MA 02115 USA.
EM crclark@partners.org
FU National Heart, Lung, and Blood Institute [HHSN268201300046C,
   HHSN268201300047C, HHSN268201300048C, HHSN268201300049C,
   HHSN268201300050C]; National Institute on Biomedical Imaging and
   Bioengineering; National Institutes of Aging [K08AG032357]; National
   Institute on Minority Health and Health Disparities
FX The Jackson Heart Study is supported by contracts HHSN268201300046C,
   HHSN268201300047C, HHSN268201300048C, HHSN268201300049C,
   HHSN268201300050C, from the National Heart, Lung, and Blood Institute
   and the National Institute on Minority Health and Health Disparities,
   with additional support from the National Institute on Biomedical
   Imaging and Bioengineering. These analyses were supported by a grant
   from the National Institutes of Aging K08AG032357. The funders had no
   role in study design, data collection and analysis, decision to publish,
   or preparation of the manuscript.
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NR 39
TC 17
Z9 18
U1 1
U2 5
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD AUG 28
PY 2014
VL 9
IS 8
AR e105251
DI 10.1371/journal.pone.0105251
PG 10
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Science & Technology - Other Topics
GA AO4JP
UT WOS:000341303700018
PM 25166297
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Ba, YQ
   Guo, QX
   Du, AN
   Zheng, BB
   Wang, LY
   He, Y
   Guan, YH
   Xin, Y
   Shi, JJ
AF Ba, Yanqun
   Guo, Qixin
   Du, Anning
   Zheng, Beibei
   Wang, Luyang
   He, Ying
   Guan, Yihong
   Xin, Yue
   Shi, Jinjin
TI Association between serum aldehyde concentrations and metabolic syndrome
   in adults
SO ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
LA English
DT Article
DE Metabolic syndrome; Isovaleraldehyde; Valeraldehyde; Serum aldehydes;
   J-shaped relationship; Aldehyde exposure
ID OXIDATIVE STRESS; UNITED-STATES; PREVALENCE; SENSORS; IMPACT; KEAP1; HNE
AB The relationship between aldehyde exposure and metabolic syndrome is unclear; hence, we aimed to investigate the association between serum aldehyde concentrations and metabolic syndrome. We analyzed the data of 1471 participants from the National Health and Nutrition Examination Survey enrolled from 2013 to 2014. The association of serum aldehyde concentrations with metabolic syndrome was assessed via generalized linear models as well as restricted cubic splines, and endpoint events were further analyzed. After adjusting for covariates, both moderate (odds ratio [OR] = 2.73, 95% confidence interval [CI]: 1.34-5.56) and high (OR = 2.08, 95% CI: 1.06-4.07) concentrations of isovaleraldehyde were associated with the risk of metabolic syndrome. Interestingly, although a moderate concentration of valeraldehyde was associated with the risk of metabolic syndrome (OR = 1.08, 95% CI: 0.70-1.65), a high concentration was not (OR = 0.55, 95% CI: 0.17-1.79). Restricted cubic splines revealed a non-linear association between valeraldehyde and metabolic syndrome, and threshold effect analysis revealed that the inflection point for valeraldehyde concentration was 0.7 ng/mL. The results of the subgroup analysis revealed differences in the relationship of aldehyde exposure with components of metabolic syndrome. High isovaleraldehyde concentrations may increase the risk of metabolic syndrome, and valeraldehyde demonstrated a J-shaped relationship with the risk of metabolic syndrome.
C1 [Ba, Yanqun; Guo, Qixin; Zheng, Beibei; He, Ying; Guan, Yihong] Zhejiang Univ, Affiliated Hangzhou Peoples Hosp 1, Sch Med, Dept Cardiol, Hangzhou, Peoples R China.
   [Du, Anning; Wang, Luyang; Xin, Yue; Shi, Jinjin] Nanjing Med Univ, Affiliated Hosp 1, Dept Cardiol, Nanjing, Peoples R China.
C3 Zhejiang University; Nanjing Medical University
RP Guo, QX (corresponding author), Zhejiang Univ, Affiliated Hangzhou Peoples Hosp 1, Sch Med, Dept Cardiol, Hangzhou, Peoples R China.
EM Guoqixin@stu.njmu.edu.cn
RI Wang, Luyang/GWM-9174-2022
OI Guo, Qixin/0000-0002-7892-7872
FU National Natural Science Foundation of China [2017YFC1700505];
   Construction Fund of Key medical disciplines of Hangzhou [OO2020065]
FX This research was supported by the National Natural Science Foundation
   of China (grant number 2017YFC1700505) and The Construction Fund of Key
   medical disciplines of Hangzhou (grant number OO2020065).
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NR 37
TC 3
Z9 3
U1 1
U2 5
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0944-1344
EI 1614-7499
J9 ENVIRON SCI POLLUT R
JI Environ. Sci. Pollut. Res.
PD JUN
PY 2023
VL 30
IS 29
BP 74290
EP 74300
DI 10.1007/s11356-023-27459-3
EA MAY 2023
PG 11
WC Environmental Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology
GA J5JP4
UT WOS:000992741600003
PM 37204573
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Alzarea, EA
   Al-Kuraishy, HM
   Al-Gareeb, AI
   Alexiou, A
   Papadakis, M
   Beshay, ON
   Batiha, GE
AF Alzarea, Ekremah A.
   Al-Kuraishy, Hayder M.
   Al-Gareeb, Ali I.
   Alexiou, Athanasios
   Papadakis, Marios
   Beshay, Olivia N.
   Batiha, Gaber El-Saber
TI The Conceivable Role of Metabolic Syndrome in the Pathogenesis of
   Alzheimer's Disease: Cellular and Subcellular Alterations in
   Underpinning a Tale of Two
SO NEUROMOLECULAR MEDICINE
LA English
DT Review
DE Metabolic syndrome; Neuroinflammation; Alzheimer's disease; Insulin
   resistance
ID BRAIN INSULIN-RESISTANCE; RENIN-ANGIOTENSIN SYSTEM;
   HIGH-DENSITY-LIPOPROTEIN; OXIDATIVE STRESS; AMYLOID-BETA; MOUSE MODEL;
   MITOCHONDRIAL DYSFUNCTION; CEREBRAL HYPOPERFUSION; COGNITIVE FUNCTION;
   UNDERLYING CAUSE
AB Alzheimer's disease (AD)is an age-related neurodegenerative disease characterized by memory decline and cognitive impairment .AD is common in people aged > 65 years, though most of AD cases are sporadic, which accounts for 95%, and 1-5% of AD is caused by familial causes . The causes of AD are aging, environmental toxins, and cardiometabolic factors that induce the degeneration of cholinergic neurons. It has been shown that the metabolic syndrome which is a clustering of dissimilar constituents including insulin resistance (IR), glucose intolerance, visceral obesity, hypertension, and dyslipidemia is implicated in the pathogenesis of AD. Metabolic syndrome disapprovingly affects cognitive function and the development in AD by inducing the development of oxidative stress, neuroinflammation, and brain IR. These changes, together with brain IR, impair cerebrovascular reactivity causing cognitive impairment and dementia. Nevertheless, the fundamental mechanism by which metabolic syndrome persuades AD risk is not entirely explicated. Accordingly, this review aims to discuss the connotation between metabolic syndrome and AD. In conclusion, metabolic syndrome is regarded as a possible risk factor for the initiation of AD neuropathology by diverse signaling pathways such as brain IR, activation of inflammatory signaling pathways, neuroinflammation, defective proteostasis, and dysregulation of lipid mediators.
C1 [Alzarea, Ekremah A.] Jouf Univ, Coll Med, Dept Pathol, Hematopathol, Sakaka, Saudi Arabia.
   [Al-Kuraishy, Hayder M.] Mustansiriyah Univ, Coll Med, Dept Clin Pharmacol & Med, Baghdad, Iraq.
   [Al-Gareeb, Ali I.] Jabir ibn Hayyan Med Univ, POB13, Kufa, Iraq.
   [Alexiou, Athanasios] Chandigarh Univ, Univ Ctr Res & Dev, Chandigarh Ludhiana Highway, Mohali, Punjab, Australia.
   [Alexiou, Athanasios] Funogen, Dept Res & Dev, Athens, Greece.
   [Papadakis, Marios] Univ Witten Herdecke, Univ Hosp Witten Herdecke, Dept Surg 2, Heusnerstr 40, D-42283 Wuppertal, Germany.
   [Beshay, Olivia N.] Minia Univ, Fac Pharm, Dept Biochem, Al Minya 61519, Egypt.
   [Batiha, Gaber El-Saber] Damanhour Univ, Fac Vet Med, Dept Pharmacol & Therapeut, Damanhour 22511, Albeheira, Egypt.
C3 Al Jouf University; Mustansiriya University; Jabir Ibn Hayyan University
   for Medical & Pharmaceutical Sciences; Witten Herdecke University;
   Egyptian Knowledge Bank (EKB); Minia University; Egyptian Knowledge Bank
   (EKB); Damanhour University
RP Papadakis, M (corresponding author), Univ Witten Herdecke, Univ Hosp Witten Herdecke, Dept Surg 2, Heusnerstr 40, D-42283 Wuppertal, Germany.
EM eaalzare@ju.edu.sa; haydermutter@uomustansiriyah.edu.iq;
   dr.alialgareeb78@jmu.edu.iq; athanasios.th.alexiou@gmail.com;
   drmariospapadakis@gmail.com; olivia.nady@mu.edu.eg;
   gaberbatiha@gmail.com
RI al-kuraishy, hayder/AAE-6673-2019; Alexiou, Athanasios/AAT-8491-2021;
   Papadakis, Marios/AAI-6622-2020; Al-Gareeb, Ali/I-8330-2019
OI Al-Gareeb, Ali/0000-0001-8284-8897
FU Open Access funding enabled and organized by Projekt DEAL. This work was
   supported by the University of Witten-Herdecke Germany.
FX Not applicable.
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NR 210
TC 0
Z9 0
U1 0
U2 0
PU HUMANA PRESS INC
PI TOTOWA
PA 999 RIVERVIEW DRIVE SUITE 208, TOTOWA, NJ 07512 USA
SN 1535-1084
EI 1559-1174
J9 NEUROMOL MED
JI Neuromol. Med.
PD MAY 16
PY 2025
VL 27
IS 1
AR 35
DI 10.1007/s12017-025-08832-6
PG 23
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 2RX9D
UT WOS:001489863600001
PM 40379890
DA 2025-06-11
ER

PT J
AU Seeman, TE
   McEwen, BS
   Rowe, JW
   Singer, BH
AF Seeman, TE
   McEwen, BS
   Rowe, JW
   Singer, BH
TI Allostatic load as a marker of cumulative biological risk: MacArthur
   studies of successful aging
SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF
   AMERICA
LA English
DT Article
ID CARDIOVASCULAR-DISEASE; MEDIATORS; STRESS; HEALTH; MEN
AB Allostatic load (AL) has been proposed as a new conceptualization of cumulative biological burden exacted on the body through attempts to adapt to life's demands. Using a multisystem summary measure of AL, we evaluated its capacity to predict four categories of health outcomes, 7 years after a baseline survey of 1,189 men and women age 70-79. Higher baseline AL scores were associated with significantly increased risk for 7-year mortality as well as declines in cognitive and physical functioning and were marginally associated with incident cardiovascular disease events, independent of standard socio-demographic characteristics and baseline health status. The summary AL measure was based on 10 parameters of biological functioning, four of which are primary mediators in the cascade from perceived challenges to downstream health outcomes. Six of the components are secondary mediators reflecting primarily components of the metabolic syndrome (syndrome X). AL was a better predictor of mortality and decline in physical functioning than either the syndrome X or primary mediator components alone. The findings support the concept of AL as a measure of cumulative biological burden.
C1 Univ Calif Los Angeles, Sch Med, Div Geriatr, Los Angeles, CA 90095 USA.
   Rockefeller Univ, Neuroendocrinol Lab, New York, NY 10021 USA.
   Aetna Inc, Hartford, CT 06156 USA.
   Princeton Univ, Off Populat Res, Princeton, NJ 08544 USA.
C3 University of California System; University of California Los Angeles;
   University of California Los Angeles Medical Center; David Geffen School
   of Medicine at UCLA; Rockefeller University; Princeton University
RP Seeman, TE (corresponding author), Univ Calif Los Angeles, Sch Med, Div Geriatr, 10945 Le Conte Ave,Suite 2339, Los Angeles, CA 90095 USA.
RI McEwen, Bruce/Z-1630-2019
FU NIA NIH HHS [AG 17056, AG-00586] Funding Source: Medline
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NR 23
TC 995
Z9 1187
U1 2
U2 81
PU NATL ACAD SCIENCES
PI WASHINGTON
PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA
SN 0027-8424
J9 P NATL ACAD SCI USA
JI Proc. Natl. Acad. Sci. U. S. A.
PD APR 10
PY 2001
VL 98
IS 8
BP 4770
EP 4775
DI 10.1073/pnas.081072698
PG 6
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 421HV
UT WOS:000168059700090
PM 11287659
OA Green Published
DA 2025-06-11
ER

PT J
AU Pickup, JC
AF Pickup, JC
TI Inflammation and activated innate immunity in the pathogenesis of type 2
   diabetes
SO DIABETES CARE
LA English
DT Review
ID C-REACTIVE PROTEIN; TUMOR-NECROSIS-FACTOR; SERUM SIALIC-ACID;
   ACUTE-PHASE PROTEINS; CORONARY-HEART-DISEASE; PPAR-GAMMA AGONISTS;
   BLOOD-CELL COUNT; INSULIN-RESISTANCE; FACTOR-ALPHA; METABOLIC SYNDROME
AB There is increasing evidence that an ongoing cytokine-induced acute-phase response (sometimes called low-grade inflammation, but part of a widespread activation of the innate immune system) is closely involved in the pathogenesis of type 2 diabetes and associated complications such as dyslipidemia and atherosclerosis. Elevated circulating inflammatory markers such as C-reactive protein and interleukin-6 predict the development of type 2 diabetes, and several drugs with anti-inflammatory properties lower both acute-phase reactants and glycemia (aspirin and thiazolidinediones) and possibly decrease the risk of developing type 2 diabetes (statins). Among the risk factors for type 2 diabetes, which are also known to be associated with activated innate immunity, are age, inactivity, certain dietary components, smoking, psychological stress, and low birth weight. Activated immunity may be the common antecedent of both type 2 diabetes and atherosclerosis, which probably develop in parallel. Other features of type 2 diabetes, such as fatigue, sleep disturbance, and depression, are likely to be at least partly due to hypercytokinemia and activated innate immunity. Further research is needed to confirm and clarify the role of innate immunity in type 2 diabetes, particularly the extent to which inflammation in type 2 diabetes is a primary abnormality or partly secondary to hyperglycemia, obesity, atherosclerosis, or other common features of the disease.
C1 Guys Hosp, Metab Unit, GKT Sch Med, London SE1 9RT, England.
C3 University of London; King's College London; Guy's & St Thomas' NHS
   Foundation Trust
RP Guys Hosp, Metab Unit, GKT Sch Med, Thomas Guy House, London SE1 9RT, England.
EM john.pickup@kcl.ac.uk
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NR 136
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U2 111
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0149-5992
EI 1935-5548
J9 DIABETES CARE
JI Diabetes Care
PD MAR
PY 2004
VL 27
IS 3
BP 813
EP 823
DI 10.2337/diacare.27.3.813
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 779NU
UT WOS:000189307400032
PM 14988310
DA 2025-06-11
ER

PT J
AU Gupta, A
   Gupta, Y
   Anjana, RM
   Ranjani, H
   Kalaivani, M
   Goyal, A
   Jagannathan, N
   Sharma, S
   Mittal, B
   Radhakrishnan, VK
   Garg, V
   Sharma, G
   Jyotsna, VP
   Sagar, R
   Mohan, V
   Tandon, N
AF Gupta, Anu
   Gupta, Yashdeep
   Anjana, Ranjit Mohan
   Ranjani, H.
   Kalaivani, Mani
   Goyal, Alpesh
   Jagannathan, N.
   Sharma, Sandhya
   Mittal, Bhavika
   Radhakrishnan, Vinoth Kumar
   Garg, Vineeta
   Sharma, Gautam
   Jyotsna, Viveka P.
   Sagar, Rajesh
   Mohan, Viswanathan
   Tandon, Nikhil
TI Association of cognitive impairment with sleep quality, depression and
   cardiometabolic risk factors in individuals with type 2 diabetes
   mellitus: A cross sectional study
SO JOURNAL OF DIABETES AND ITS COMPLICATIONS
LA English
DT Article
DE Cognition; Diabetes; Asia; MoCA; Cognitive impairment; Middle-age;
   Complications; Depression; Sleep
ID DEMENTIA PREVENTION; BLOOD-PRESSURE; BRAIN RESERVE; PREVALENCE;
   INTERVENTION; VALIDITY; DECLINE; INDIA
AB Aim: The aim of this study was to evaluate the association of cognitive impairment with sleep quality, depression, and cardiometabolic risk factors among participants with type 2 diabetes mellitus. Methods: Subjects underwent clinical interview to capture socio-demographic details, medical history, sleep quality, presence of depression, along with anthropometric and biochemical measurements. A detailed neuropsychological assessment [Montreal cognitive assessment scale (MoCA), Trail making A and B, Digit span, Spatial span, Letter Number Sequencing] was done. Cognitive impairment was defined as MoCA score of <23. Results: Participants (n = 250, 50% women, 63.6% middle-age) had a mean (+/- SD) age of 53.6 (+/- 9.1) years and HbA1c of 55.1 +/- 6.8 mmol/mol (7.2 +/- 0.6%). Cognitive impairment was present in 57 (22.8%) participants. In the middle-age subgroup, cognitive impairment was higher (23.9%) than those in the fourth decade (6.3%), but comparable (24.0%) to the older age (60-70 years) individuals. Diabetes-related vascular complications [Odds ratio (95% CI) 2.03 (1.05, 3.94)]; hypertension [2.00 (1.04, 3.84)], depression [2.37 (1.24, 4.55)] and lower education [2.73 (1.42, 5.23)] had a significant association with cognitive impairment on multivariate logistic regression analysis. Conclusion: The high burden of cognitive impairment calls for an urgent need to establish longitudinal cohorts in midlife to understand this population's cognitive trajectories and see the influence of various bio-psychosocial variables.
C1 [Gupta, Anu] All India Inst Med Sci, Dept Neurol, New Delhi, India.
   [Gupta, Yashdeep; Goyal, Alpesh; Sharma, Sandhya; Mittal, Bhavika; Garg, Vineeta; Jyotsna, Viveka P.; Tandon, Nikhil] All India Inst Med Sci, Dept Endocrinol & Metab, New Delhi 110029, India.
   [Anjana, Ranjit Mohan; Radhakrishnan, Vinoth Kumar; Mohan, Viswanathan] Madras Diabet Res Fdn, Dept Diabetol, Chennai, Tamil Nadu, India.
   [Ranjani, H.; Jagannathan, N.] Madras Diabet Res Fdn, Dept Translat Res, Chennai, Tamil Nadu, India.
   [Kalaivani, Mani] All India Inst Med Sci, Dept Biostat, New Delhi, India.
   [Sharma, Gautam] All India Inst Med Sci, Dept Cardiol, New Delhi, India.
   [Sagar, Rajesh] All India Inst Med Sci, Dept Psychiat, New Delhi, India.
C3 All India Institute of Medical Sciences (AIIMS) New Delhi; All India
   Institute of Medical Sciences (AIIMS) New Delhi; Madras Diabetes
   Research Foundation; Madras Diabetes Research Foundation; All India
   Institute of Medical Sciences (AIIMS) New Delhi; All India Institute of
   Medical Sciences (AIIMS) New Delhi; All India Institute of Medical
   Sciences (AIIMS) New Delhi
RP Gupta, Y (corresponding author), All India Inst Med Sci, Dept Endocrinol & Metab, New Delhi 110029, India.
EM yashdeep@aiims.edu
RI Mani, Kalaivani/IAN-9740-2023; Sagar, Rajesh/L-7775-2016; Sharma,
   Sandhya/AAT-4135-2020; Goyal, Alpesh/AAF-7732-2019; Gupta,
   Yashdeep/J-4450-2014; Viswanathan, Mohan/C-2321-2009; Sharma, Santosh
   K/AAP-5386-2021
OI Mohan, Viswanathan/0000-0001-5038-6210; Goyal,
   Alpesh/0000-0003-0922-5022; Sharma, Santosh K/0000-0002-3715-2054;
   SAGAR, RAJESH/0000-0003-4563-7841
FU Indian Council for Medical Research, India [55/3/1]
FX This research was funded by the Indian Council for Medical Research,
   India to Yashdeep Gupta as Principal investigator with grant sanction
   No. 55/3/1/Yoga-Diab./17-NCD-III.
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NR 36
TC 7
Z9 7
U1 0
U2 12
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1056-8727
EI 1873-460X
J9 J DIABETES COMPLICAT
JI J. Diabetes Complications
PD AUG
PY 2021
VL 35
IS 8
AR 107970
DI 10.1016/j.jdiacomp.2021.107970
EA JUL 2021
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism
GA TP4VI
UT WOS:000677592800002
PM 34119405
DA 2025-06-11
ER

PT J
AU Kolling, LJ
   Khan, K
   Wang, RX
   Pierson, SR
   Hartman, BD
   Balasubramanian, N
   Guo, DF
   Rahmouni, K
   Marcinkiewcz, CA
AF Kolling, Louis J.
   Khan, Kanza
   Wang, Ruixiang
   Pierson, Samantha R.
   Hartman, Benjamin D.
   Balasubramanian, Nagalakshmi
   Guo, Deng-Fu
   Rahmouni, Kamal
   Marcinkiewcz, Catherine A.
TI Interaction of serotonin/GLP-1 circuitry in a dual preclinical model for
   psychiatric disorders and metabolic dysfunction
SO PSYCHIATRY RESEARCH
LA English
DT Article
DE 5-HT; Semaglutide; PPG; Insulin; Diabetes; Adolescent isolation; POMC;
   Isolation stress; Depression; Anxiety; Pain; Social deficit
ID ADOLESCENT SOCIAL-ISOLATION; DORSAL RAPHE NUCLEUS; PROOPIOMELANOCORTIN
   NEURONS; SEROTONERGIC MODULATION; UNITED-STATES; ACTIVATION; CHILDHOOD;
   RECEPTORS; INFLAMMATION; DEPRESSION
AB Isolation of rodents throughout adolescence is known to induce many behavioral abnormalities which resemble neuropsychiatric disorders. Separately, this paradigm has also been shown to induce long-term metabolic changes consistent with a pre-diabetic state. Here, we investigate changes in central serotonin (5-HT) and glucagon-like peptide 1 (GLP-1) neurobiology that dually accompany behavioral and metabolic outcomes following social isolation stress throughout adolescence. We find that adolescent-isolation mice exhibit elevated blood glucose levels, impaired peripheral insulin signaling, altered pancreatic function, and fattier body composition without changes in bodyweight. These mice further exhibited disruptions in sleep and enhanced nociception. Using bulk and spatial transcriptomic techniques, we observe broad changes in neural 5-HT, GLP-1, and appetitive circuits. We find 5-HT neurons of adolescent-isolation mice to be more excitable, transcribe fewer copies of Glp1r (mRNA; GLP-1 receptor), and demonstrate resistance to the inhibitory effects of the GLP-1R agonist semaglutide on action potential thresholds. Surprisingly, we find that administration of semaglutide, commonly prescribed to treat metabolic syndrome, induced deficits in social interaction in group-housed mice and rescued social deficits in isolated mice. Overall, we find that central 5-HT circuitry may simultaneously influence mental well-being and metabolic health in this model, via interactions with GLP-1 and proopiomelanocortin circuitry.
C1 [Kolling, Louis J.; Wang, Ruixiang; Pierson, Samantha R.; Hartman, Benjamin D.; Balasubramanian, Nagalakshmi; Guo, Deng-Fu; Rahmouni, Kamal; Marcinkiewcz, Catherine A.] Univ Iowa, Dept Neurosci & Pharmacol, Iowa City, IA 52242 USA.
   [Khan, Kanza] Daemen Univ, Psychol Sci, Amherst, NY USA.
C3 University of Iowa; Daemen University
RP Marcinkiewcz, CA (corresponding author), Univ Iowa, Dept Neurosci & Pharmacol, Iowa City, IA 52242 USA.
EM Catherine-marcinkiewcz@uiowa.edu
RI Marcinkiewcz, Catherine/X-2339-2019; Rahmouni, Kamal/Y-1788-2019; Wang,
   Ruixiang/AAE-7498-2021
OI Balasubramanian, Nagalakshmi/0000-0001-6278-0231; Khan,
   Kanza/0000-0003-4018-7669; Kolling, Louis/0000-0003-0597-0199; guo, deng
   fu/0000-0001-7096-8613; Wang, Ruixiang/0000-0003-0316-0600; Pierson,
   Samantha/0000-0002-8376-4465; Rahmouni, Kamal/0000-0001-5136-6748
FU NARSAD Young Investigator Award [T32 NS045549, T32 DK112751]
FX This work was supported by a NARSAD Young Investigator Award, and a
   Williams-Cannon Faculty Fellowship. L.K. was supported by T32 NS045549
   and K.K. was supported by T32 DK112751. The authors have no competing
   interests to declare, scientific or financial.
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NR 91
TC 1
Z9 1
U1 6
U2 9
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0165-1781
EI 1872-7123
J9 PSYCHIAT RES
JI Psychiatry Res.
PD JUL
PY 2024
VL 337
DI 10.1016/j.psychres.2024.115951
EA MAY 2024
PG 14
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA TM7Y5
UT WOS:001241758200001
PM 38735240
DA 2025-06-11
ER

PT J
AU Osborne, PJ
   Jimenez-Torres, GJ
   Landa, Y
   Mahoney, J
   Madan, A
AF Osborne, Patricia J.
   Jimenez-Torres, Gladys Janice
   Landa, Yulia
   Mahoney, Jane
   Madan, Alok
TI Chronic pain management group psychotherapy for psychiatric inpatients:
   A pilot study
SO BULLETIN OF THE MENNINGER CLINIC
LA English
DT Article
ID COGNITIVE-BEHAVIORAL THERAPY; RANDOMIZED CONTROLLED-TRIAL; MAJOR
   DEPRESSIVE DISORDER; COMMITMENT THERAPY; EMOTION REGULATION; METABOLIC
   SYNDROME; ANXIETY DISORDERS; SLEEP DISTURBANCE; SELF-MANAGEMENT;
   PRIMARY-CARE
AB Individuals with serious mental illness (SMI) experience significant comorbid chronic pain (CP). Little is known about CP management in psychiatric inpatient settings. To address this gap in clinical practice, the authors developed CP management group psychotherapy for adult inpatients with SMI. In this report, the authors highlight (1) the theoretical underpinnings of and execution of the psychotherapy group, (2) the characteristics of participants in the pilot phase of the group, and (3) outcomes of group participants. Data were collected from 16 participants in the pain management psychotherapy group. The mean number of groups attended was two (SD = 1.7). Participants endorsed pain across five regions of the body with high pain intensity and severity. Improvements in depression, anxiety, somatic, and emotional regulation symptoms were evidenced during the course of treatment. CP group psychotherapy may be an effective modality to disseminate "best practices" and prevent diagnostic overshadowing for SMI patients.
C1 [Osborne, Patricia J.; Landa, Yulia] James J Peters VA Med Ctr, VISN South Mental Illness Res Educ & Clin Ctr 2, Bronx, NY USA.
   [Osborne, Patricia J.; Landa, Yulia] Icahn Sch Med Mt Sinai, Dept Psychiat, New York, NY 10029 USA.
   [Jimenez-Torres, Gladys Janice; Mahoney, Jane; Madan, Alok] Baylor Coll Med, Menninger Dept Psychiat & Behav Sci, Houston, TX 77030 USA.
C3 US Department of Veterans Affairs; Veterans Health Administration (VHA);
   James J. Peters VA Medical Center; Icahn School of Medicine at Mount
   Sinai; Baylor College of Medicine
RP Madan, A (corresponding author), 12301 South Main St, Houston, TX 77035 USA.
EM amadan@bcm.edu
FU Menninger Foundation; McNair Medical Institute; Office of Academic
   Affiliations, Advanced Fellowship Program in Mental Illness Research and
   Treatment, Department of Veterans Affairs
FX This research was supported in part by funding from the Menninger
   Foundation and the McNair Medical Institute (Dr. Madan). Writing of this
   article was supported by the Office of Academic Affiliations, Advanced
   Fellowship Program in Mental Illness Research and Treatment, Department
   of Veterans Affairs (Dr. Osborne).
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NR 84
TC 4
Z9 4
U1 0
U2 15
PU GUILFORD PUBLICATIONS INC
PI NEW YORK
PA 370 SEVENTH AVE, SUITE 1200, NEW YORK, NY 10001-1020 USA
SN 0025-9284
EI 1943-2828
J9 B MENNINGER CLIN
JI Bull. Menninger Clin.
PD SPR
PY 2017
VL 81
IS 2
BP 123
EP 149
PG 27
WC Psychiatry; Psychology, Psychoanalysis
WE Social Science Citation Index (SSCI)
SC Psychiatry; Psychology
GA EX5RX
UT WOS:000403301200002
PM 28609146
DA 2025-06-11
ER

PT J
AU Kuo, WC
   Ersig, AL
   Johnson, HM
   Brown, RL
   Oakley, LD
   Hagen, EW
   Barnet, JH
   Peppard, PE
AF Kuo, Wan-chin
   Ersig, Anne L.
   Johnson, Heather M.
   Brown, Roger L.
   Oakley, Linda D.
   Hagen, Erika W.
   Barnet, Jodi H.
   Peppard, Paul E.
TI Association between stressful life events and non-optimal lipid levels
   among women with hyperlipidaemia
SO EUROPEAN JOURNAL OF CARDIOVASCULAR NURSING
LA English
DT Article
DE Life events; Stress; Hyperlipidaemia; Suboptimal hyperlipidaemia; Gender
   differences
ID METABOLIC SYNDROME; GENDER-DIFFERENCES; RISK-FACTORS; PREVALENCE;
   DEPRESSION; RESOURCES; HEALTH
AB Aims Psychological stress has been linked to lipid dysregulation with noticeable gender differences, but it remains unclear whether women are more susceptible to non-optimal lipid levels than men, when experiencing stressful life events. This study aims to examine the association between stressful life events and non-optimal lipid levels among persons with hyperlipidaemia and whether the association differs between men and women. Methods and results A nested case-control study was performed using data from the Wisconsin Sleep Cohort (WSC) Study from 2011 to 2015, including 224 participants with hyperlipidaemia and without a history of myocardial infarction or heart failure. Among them, 63 participants with non-optimal LDL cholesterol or triglyceride levels were identified as cases, and 161 participants with optimal LDL cholesterol and triglyceride levels were identified as controls. Cases and controls were traced back to their self-reported life events collected through the Retirement and Sleep Trajectories study during 2010-11. The association between stressful life events and non-optimal lipid levels was examined using multivariable logistic regression; confounding effects were addressed using propensity score weighting and Mahalanobis distance matching; gender differences were examined using subgroup analysis. Results showed that a higher number of stressful life events during 2010-11 was associated with greater odds of non-optimal lipid levels during 2011-15 (odds ratio = 1.45, P = 0.03) among women with hyperlipidaemia, whereas the association was not significant among men with hyperlipidaemia (P = 0.910). Conclusion Future studies are needed to examine the underlying mechanisms that explain gender differences in the association between stressful life events and non-optimal lipid levels. Registration ClinicalTrials.gov NCT00005557
C1 [Kuo, Wan-chin; Ersig, Anne L.; Brown, Roger L.] Univ Wisconsin Madison, Sch Nursing, Madison, WI 53706 USA.
   [Johnson, Heather M.] Florida Atlantic Univ, Baptist Hlth South Florida, Boca Raton Reg Hospital, Christine E Lynn Womens Hlth & Wellness Inst, Boca Raton, FL USA.
   [Hagen, Erika W.; Barnet, Jodi H.; Peppard, Paul E.] Univ Wisconsin Madison, Sch Med & Publ Hlth, Dept Populat Hlth Sci, Madison, WI 53706 USA.
C3 University of Wisconsin System; University of Wisconsin Madison; State
   University System of Florida; Florida Atlantic University; University of
   Wisconsin System; University of Wisconsin Madison
RP Kuo, WC (corresponding author), Univ Wisconsin Madison, Sch Nursing, Madison, WI 53706 USA.
EM wkuo4@wisc.edu
RI Kuo, Wan-chin/HHN-6428-2022
OI Johnson, Heather/0000-0002-4916-3519; Peppard, Paul/0000-0001-6019-2743;
   Barnet, Jodi/0000-0003-0834-0504; Brown, Roger/0000-0001-9044-1085; Kuo,
   Wan-chin/0000-0002-5658-6077; Ersig, Anne/0000-0002-4169-8287
FU National Institutes of Health (NIH) [R01HL62252, 1R01AG036838,
   1UL1RR02501]
FX This is a secondary data analysis using data from theWSC and Retirement
   and Sleep Trajectories (REST) studies. The Wisconsin Sleep Cohort (WSC)
   and REST studies were supported by grants from the National Institutes
   of Health (NIH): R01HL62252, 1R01AG036838, and 1UL1RR02501.
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NR 52
TC 1
Z9 1
U1 1
U2 4
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1474-5151
EI 1873-1953
J9 EUR J CARDIOVASC NUR
JI Eur. J. Cardiovasc. Nurs.
PD MAR 1
PY 2023
VL 22
IS 2
BP 210
EP 219
DI 10.1093/eurjcn/zvac032
EA JUN 2022
PG 10
WC Cardiac & Cardiovascular Systems; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Cardiovascular System & Cardiology; Nursing
GA A5WM7
UT WOS:000855415700001
PM 35714051
DA 2025-06-11
ER

PT J
AU Chamberlain, SR
   Cavanagh, J
   de Boer, P
   Mondelli, V
   Jones, DNC
   Drevets, WC
   Cowen, PJ
   Harrison, NA
   Pointon, L
   Pariante, CM
   Bullmore, ET
AF Chamberlain, Samuel R.
   Cavanagh, Jonathan
   de Boer, Peter
   Mondelli, Valeria
   Jones, Declan N. C.
   Drevets, Wayne C.
   Cowen, Philip J.
   Harrison, Neil A.
   Pointon, Linda
   Pariante, Carmine M.
   Bullmore, Edward T.
TI Treatment-resistant depression and peripheral C-reactive protein
SO BRITISH JOURNAL OF PSYCHIATRY
LA English
DT Article
ID NEURO-IMMUNOLOGICAL FACTORS; NECROSIS-FACTOR-ALPHA; METABOLIC SYNDROME;
   INTERFERON-ALPHA; ADIPOSE-TISSUE; INFLAMMATION; SYMPTOMS; CYTOKINES;
   ANTIDEPRESSANTS; PATHOPHYSIOLOGY
AB Background
   C-reactive protein (CRP) is a candidate biomarker for major depressive disorder (MDD), but it is unclear how peripheral CRP levels relate to the heterogeneous clinical phenotypes of the disorder.
   Aim
   To explore CRP in MDD and its phenotypic associations.
   Method
   We recruited 102 treatment-resistant patients with MDD currently experiencing depression, 48 treatment-responsive patients with MDD not currently experiencing depression, 48 patients with depression who were not receiving medication and 54 healthy volunteers. High-sensitivity CRP in peripheral venous blood, body mass index (BMI) and questionnaire assessments of depression, anxiety and childhood trauma were measured. Group differences in CRP were estimated, and partial least squares (PLS) analysis explored the relationships between CRP and specific clinical phenotypes.
   Results
   Compared with healthy volunteers, BMI-corrected CRP was significantly elevated in the treatment-resistant group (P = 0.007; Cohen's d = 0.47); but not significantly so in the treatment-responsive (d = 0.29) and untreated (d = 0.18) groups. PLS yielded an optimal two-factor solution that accounted for 34.7% of variation in clinical measures and for 36.0% of variation in CRP. Clinical phenotypes most strongly associated with CRP and heavily weighted on the first PLS component were vegetative depressive symptoms, BMI, state anxiety and feeling unloved as a child or wishing for a different childhood.
   Conclusions
   CRP was elevated in patients with MDD, and more so in treatment-resistant patients. Other phenotypes associated with elevated CRP included childhood adversity and specific depressive and anxious symptoms. We suggest that patients with MDD stratified for proinflammatory biomarkers, like CRP, have a distinctive clinical profile that might be responsive to second-line treatment with anti-inflammatory drugs.
C1 [Chamberlain, Samuel R.; Pointon, Linda; Bullmore, Edward T.] Univ Cambridge, Dept Psychiat, Cambridge, England.
   [Chamberlain, Samuel R.; Bullmore, Edward T.] Cambridgeshire & Peterborough NHS Fdn Trust, Cambridge, England.
   [Cavanagh, Jonathan] Univ Glasgow, Inst Hlth & Wellbeing, Glasgow, Lanark, Scotland.
   [de Boer, Peter] Janssen Pharmaceut NV, Janssen Res & Dev, Neurosci, Beerse, Belgium.
   [Mondelli, Valeria] Maurice Wohl Clin Neurosci Inst, London, England.
   [Jones, Declan N. C.] Janssen Res & Dev, Neurosci, London, England.
   [Drevets, Wayne C.] Janssen Res & Dev, Neurosci, Titusville, NJ USA.
   [Cowen, Philip J.] Univ Oxford, Dept Psychiat, Warneford Hosp, Oxford, England.
   [Harrison, Neil A.] Univ Sussex, Brighton & Sussex Med Sch, Brighton, E Sussex, England.
   [Harrison, Neil A.] Sussex Partnership NHS Fdn Trust, Swandean, England.
   [Pariante, Carmine M.] Kings Coll London, Stress Psychiat & Immunol Lab, Maurice Wohl Clin Neurosci Inst, London, England.
   [Pariante, Carmine M.] Kings Coll London, Perinatal Psychiat, Maurice Wohl Clin Neurosci Inst, London, England.
   [Bullmore, Edward T.] GlaxoSmithKline R&D, Immunopsychiat, Immunoinflammat Therapeut Area Unit, Stevenage, Herts, England.
C3 University of Cambridge; University of Glasgow; Johnson & Johnson;
   Janssen Pharmaceuticals; Johson & Johnson Belgium; Johnson & Johnson;
   Janssen Pharmaceuticals; University of Oxford; University of Brighton;
   University of Sussex; University of London; King's College London;
   University of London; King's College London; GlaxoSmithKline;
   Glaxosmithkline United Kingdom
RP Chamberlain, SR (corresponding author), Addenbrookes Hosp, Dept Psychiat, Box 189 Level E4, Cambridge CB2 0QQ, England.
EM src33@cam.ac.uk
RI Mondelli, Valeria/K-8988-2016; Bullmore, Ed/C-1706-2012; Chamberlain,
   Samuel/A-7839-2008; Pariante, Carmine Maria/B-1297-2011
OI Chamberlain, Samuel/0000-0001-7014-8121; Harrison,
   Neil/0000-0002-9584-3769; Mondelli, Valeria/0000-0001-8690-6839;
   Pariante, Carmine Maria/0000-0002-9132-5091; Cowen,
   Philip/0000-0001-5518-6138
FU Wellcome Trust; Janssen; GlaxoSmithKline; Lundbeck; Pfizer; National
   Institute of Health Research (NIHR) Clinical Research Network: Kent,
   Surrey and Sussex Eastern; Cambridge NIHR Biomedical Research Centre;
   MRC [MR/K022202/1, G108/603, MR/N029488/1, MR/J002739/1] Funding Source:
   UKRI
FX This work was funded by a Wellcome Trust strategy award to the
   Neuroimmunology of Mood Disorders and Alzheimer's Disease (NIMA)
   Consortium, which is also funded by Janssen, GlaxoSmithKline, Lundbeck
   and Pfizer. Recruitment of patients was supported by the National
   Institute of Health Research (NIHR) Clinical Research Network: Kent,
   Surrey and Sussex & Eastern. The immunological work of the NIMA
   consortium is supported by the Cambridge NIHR Biomedical Research
   Centre.
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NR 65
TC 261
Z9 273
U1 4
U2 74
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1250
EI 1472-1465
J9 BRIT J PSYCHIAT
JI Br. J. Psychiatry
PD JAN
PY 2019
VL 214
IS 1
BP 11
EP 19
DI 10.1192/bjp.2018.66
PG 9
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA HF5XV
UT WOS:000454308400004
PM 29764522
OA Green Submitted, Green Accepted, Green Published, hybrid
HC Y
HP N
DA 2025-06-11
ER

PT J
AU MacKay, JC
   James, JS
   Cayer, C
   Kent, P
   Anisman, H
   Merali, Z
AF MacKay, Jennifer Christine
   James, Jonathan Stewart
   Cayer, Christian
   Kent, Pamela
   Anisman, Hymie
   Merali, Zul
TI Protracted Effects of Juvenile Stressor Exposure Are Mitigated by Access
   to Palatable Food
SO PLOS ONE
LA English
DT Article
ID ADULT MALE RATS; INSULIN-RESISTANCE; GLUCOSE-INTOLERANCE; BEHAVIORAL
   DESPAIR; SOCIAL-ISOLATION; EATING BEHAVIOR; OBESITY; RESPONSES; DIET;
   ADOLESCENTS
AB Stressor experiences during the juvenile period may increase vulnerability to anxiety and depressive-like symptoms in adulthood. Stressors may also promote palatable feeding, possibly reflecting a form of self-medication. The current study investigated the short-and long-term consequences of a stressor applied during the juvenile period on anxiety-and depressive-like behavior measured by the elevated plus maze (EPM), social interaction and forced swim test (FST). Furthermore, the effects of stress on caloric intake, preference for a palatable food and indices of metabolic syndrome and obesity were assessed. Male Wistar rats exposed to 3 consecutive days of variable stressors on postnatal days (PD) 27-29, displayed elevated anxiety-like behaviors as adults, which could be attenuated by consumption of a palatable high-fat diet. However, consumption of a palatable food in response to a stressor appeared to contribute to increased adiposity.
C1 [MacKay, Jennifer Christine; James, Jonathan Stewart; Cayer, Christian; Kent, Pamela; Merali, Zul] Univ Ottawa, Sch Psychol, Ottawa, ON K1N 6N5, Canada.
   [Merali, Zul] Univ Ottawa, Dept Psychiat, Ottawa, ON K1N 6N5, Canada.
   [Merali, Zul] Univ Ottawa, Dept Cellular & Mol Med, Ottawa, ON K1N 6N5, Canada.
   [Anisman, Hymie] Carleton Univ, Inst Neurosci, Ottawa, ON K1S 5B6, Canada.
   [MacKay, Jennifer Christine; James, Jonathan Stewart; Cayer, Christian; Kent, Pamela; Merali, Zul] Univ Ottawa, Mental Hlth Res Inst, Ottawa, ON K1N 6N5, Canada.
C3 University of Ottawa; University of Ottawa; University of Ottawa;
   Carleton University; University of Ottawa
RP Merali, Z (corresponding author), Univ Ottawa, Sch Psychol, Ottawa, ON K1N 6N5, Canada.
EM Zul.Merali@uottawa.ca
RI Kent, Pamela/KWT-4413-2024
OI Rose, J Christine/0000-0002-9573-2399
FU Canadian Institute for Health Research [275228]; Canadian Health
   Research Institutes doctoral Canada Graduate Scholarship awarded
FX This project was funded by an operating grant (Application No. 275228)
   from the Canadian Institute for Health Research (CIHR:
   http://www.cihr-irsc.gc.ca) awarded to Zul Merali, and by a Canadian
   Health Research Institutes doctoral Canada Graduate Scholarship awarded
   to J. Christine MacKay. The funders had no role in study design, data
   collection and analysis, decision to publish, or preparation of the
   manuscript.
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NR 79
TC 11
Z9 14
U1 0
U2 11
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAY 6
PY 2014
VL 9
IS 5
AR e96573
DI 10.1371/journal.pone.0096573
PG 10
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA AJ9KS
UT WOS:000338029800085
PM 24801635
OA Green Accepted, Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Pietrzak, M
AF Pietrzak, Max
TI Adhesive capsulitis: An age related symptom of metabolic syndrome and
   chronic low-grade inflammation?
SO MEDICAL HYPOTHESES
LA English
DT Article
ID BLOOD-BRAIN-BARRIER; FROZEN SHOULDER; PHYSICAL-ACTIVITY; ROTATOR-CUFF;
   EXTRACELLULAR-MATRIX; SUBACROMIAL BURSA; HYALURONIC-ACID; PUBLIC-HEALTH;
   STRESS; JOINT
AB Adhesive capsulitis (AC) is very poorly understood, particularly it's underlying etiology. Obesity and metabolic syndrome, which are strongly associated with chronic low grade inflammation, are becoming increasingly understood to underlie a raft of morbid states including upper limb pain syndromes, diabetes (DM), cardiovascular disease (CVD), cancer and central nervous system dysfunction and degeneration. Notwithstanding age, two of the strongest established risk factors for AC are DM and CVD. The hypothesis argues that similar to DM and CVD, the inflammation and capsular fibrosis seen in AC is precipitated by metabolic syndrome and chronic low grade inflammation. These pathophysiological mechanisms are highly likely to be perpetuated by upregulation of pro-inflammatory cytokine production, sympathetic dominance of autonomic balance, and neuro-immune activation. The hypothesis predicts and describes how these processes may etiologically underpin and induce each sub-classification of AC. An improved understanding of the etiology of AC may lead to more accurate diagnosis, improved management, treatment outcomes, and reduce or prevent pain, disability and suffering associated with the disease. The paper follows on with a discussion of similarities between the pathophysiology of AC to general systemic inflammatory control mechanisms whereby connective tissue (CT) fibrosis is induced as a storage depot for leukocytes and chronic inflammatory cells. The potential role of hyaluronic acid (HA), the primary component of the extracellular matrix (ECM) and CT, in the pathophysiology of AC is also discussed with potential treatment implications. Lastly, a biochemical link between physical and mental health through the ECM is described and the concept of a periventricular-limbic central driver of CT dysfunction is introduced. (C) 2016 Elsevier Ltd. All rights reserved.
C1 [Pietrzak, Max] Univ Bath, Claverton Down Rd, Bath BA2 7AY, North East Some, England.
   [Pietrzak, Max] 18 Ronald P1, Norwood, Tas 7250, Australia.
C3 University of Bath
RP Pietrzak, M (corresponding author), Univ Bath, Claverton Down Rd, Bath BA2 7AY, North East Some, England.; Pietrzak, M (corresponding author), 18 Ronald P1, Norwood, Tas 7250, Australia.
EM maxpie@hotmail.com
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NR 120
TC 40
Z9 41
U1 0
U2 18
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0306-9877
EI 1532-2777
J9 MED HYPOTHESES
JI Med. Hypotheses
PD MAR
PY 2016
VL 88
BP 12
EP 17
DI 10.1016/j.mehy.2016.01.002
PG 6
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA DF5AO
UT WOS:000371364400004
PM 26880627
DA 2025-06-11
ER

PT J
AU Jeong, JB
   Lee, JH
   Choo, MS
   Ahn, DW
   Kim, SH
   Lee, DS
   Cho, MC
   Son, H
   Jeong, H
   Yoo, S
AF Jeong, Ji Bong
   Lee, Jung Hoon
   Choo, Min Soo
   Ahn, Dong-Won
   Kim, Su Hwan
   Lee, Dong Seok
   Cho, Min Chul
   Son, Hwancheol
   Jeong, Hyeon
   Yoo, Sangjun
TI Association between life-style, metabolic syndrome and lower urinary
   tract symptoms and its impact on quality of life in men ≥ 40 years
SO SCIENTIFIC REPORTS
LA English
DT Article
ID DEPRESSION; LUTS; SEVERITY; DISEASE; STRESS
AB We aimed to assess the relationship between lifestyle-related variables, metabolic syndrome, and lower urinary tract symptoms (LUTS) in men >= 40 years. We also assessed the impact of these variables on quality of life. From 2014 to 2020, 5355 men who underwent health check-ups with I-PSS questionnaires at our institute were included in the analysis. The impact of LUTS on sleep disorders and moderate to severe degrees of stress were assessed. Multivariate analysis was performed to determine the variables associated with LUTS and prostate volume. Moderate and severe LUTS were present in 1317 (24.6%) and 211 (3.9%) men, respectively. Moderate and severe LUTS were significantly associated with the presence of sleep disorders and stress. On multivariable analysis, age, amount of life-long smoking, marital status, income, job, and decreased HDL-cholesterol were associated with the presence of moderate to severe LUTS. Although older age and the amount of life-long smoking was associated with both voiding and storage sub-score, socioeconomic status, including marital status and income were only associated with storage sub-score. In men >= 40 years, stable socioeconomic status, in addition to older age, and life-long smoking amount are associated with the presence of moderate to severe LUTS, which worsens sleep quality and stress level, by worsen storage sub-score.
C1 [Jeong, Ji Bong; Ahn, Dong-Won; Kim, Su Hwan; Lee, Dong Seok] Seoul Natl Univ, Dept Internal Med, Boramae Med Ctr, Seoul, South Korea.
   [Lee, Jung Hoon; Choo, Min Soo; Cho, Min Chul; Son, Hwancheol; Jeong, Hyeon; Yoo, Sangjun] Seoul Natl Univ, Dept Urol, Boramae Med Ctr, Sindaebang 2 I Dong, Seoul 07061, South Korea.
C3 Seoul National University (SNU); Seoul National University Hospital;
   Seoul National University (SNU); Seoul National University Hospital
RP Yoo, S (corresponding author), Seoul Natl Univ, Dept Urol, Boramae Med Ctr, Sindaebang 2 I Dong, Seoul 07061, South Korea.
EM ebend@naver.com
RI KIM, SUHWAN/GSE-0120-2022; Yoo, Sangjun/AAQ-5385-2021; CHO,
   MIN/R-7835-2019
OI Jeong, Ji Bong/0000-0003-4553-1721
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NR 29
TC 12
Z9 12
U1 0
U2 1
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD APR 27
PY 2022
VL 12
IS 1
AR 6859
DI 10.1038/s41598-022-10904-7
PG 7
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 0V9DM
UT WOS:000788639400033
PM 35477959
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU McIntyre, RS
   Alsuwaidan, M
   Goldstein, BI
   Taylor, VH
   Schaffer, A
   Beaulieu, S
   Kemp, DE
AF McIntyre, Roger S.
   Alsuwaidan, Mohammad
   Goldstein, Benjamin I.
   Taylor, Valerie H.
   Schaffer, Ayal
   Beaulieu, Serge
   Kemp, David E.
TI The Canadian Network for Mood and Anxiety Treatments (CANWAT) task force
   recommendations for the management of patients with mood disorders and
   comorbid metabolic disorders
SO ANNALS OF CLINICAL PSYCHIATRY
LA English
DT Review
DE bipolar disorder; diabetes mellitus; major depressive disorder; obesity;
   cardiovascular disease; hypertension; dyslipidemia
ID BINGE-EATING DISORDER; BIPOLAR-I DISORDER; BODY-MASS INDEX; WEIGHT-LOSS;
   DIABETES-MELLITUS; DOUBLE-BLIND; CARDIOVASCULAR-DISEASE; MAINTENANCE
   TREATMENT; COGNITIVE IMPAIRMENT; CHOLESTEROL LEVELS
AB BACKGROUND: One goal of the Canadian Network for Mood and Anxiety Treatments (CANMAT) is to develop evidence-based and best practice educational programs and recommendations. Our group conducted a comprehensive literature review to provide evidence-based recommendations for treating metabolic comorbidity in individuals with major depressive disorder (MDD) and bipolar disorder (BD).
   METHODS: We searched PubMed for all English-language articles published January 1966 to November 2010 using BD and MDD cross-referenced with metabolic syndrome, obesity, diabetes mellitus, hypertension, and dyslipidemia. That search was augmented by a review of articles reporting outcomes of an intervention targeting components of metabolic syndrome in individuals with MDD or BD.
   RESULTS: Consensus exists for the recommendation that individuals with MDD and BD should be routinely screened for risk factors that increase risk for metabolic syndrome. For excess weight, the best-studied pharmacologic approaches are metformin and topiramate, with emerging evidence for liraglutide and modafinil. For binge eating disorder, the best evidence in mood disorders was for cognitive-behavioral therapy as well as topiramate, zonisamide, and in select cases selective serotonin reuptake inhibitors. For dysglycemia, dyslipidemia, and hypertension, evidence supports cognitive-behavioral interventions and anti-diabetic, antilipidemic, and antihypertensive treatments.
   CONCLUSIONS: Comprehensive care of individuals with mood disorders should include routine evaluation of the risk and presence of metabolic syndrome and its components. Systematic evaluation of preventative and targeted treatments of metabolic syndrome in mood disorder populations is insufficient.
C1 [McIntyre, Roger S.; Alsuwaidan, Mohammad] Univ Toronto, Dept Psychiat, Univ Hlth Network, Mood Disorders Psychopharmacol Unit, Toronto, ON M5T 2S8, Canada.
   [McIntyre, Roger S.; Alsuwaidan, Mohammad] Univ Toronto, Dept Pharmacol, Univ Hlth Network, Mood Disorders Psychopharmacol Unit, Toronto, ON M5T 2S8, Canada.
   [Goldstein, Benjamin I.] Univ Toronto, Dept Psychiat, Sunnybrook Hlth Sci Ctr, Youth Bipolar Disorders Program, Toronto, ON M5T 2S8, Canada.
   [Beaulieu, Serge] McGill Univ, Dept Psychiat, Douglas Mental Hlth Univ Inst, Montreal, PQ, Canada.
   [Schaffer, Ayal] Univ Toronto, Dept Psychiat, Sunnybrook Hlth Sci Ctr, Mood & Anxiety Disorders Program, Toronto, ON M5T 2S8, Canada.
   [Kemp, David E.] Case Western Reserve Univ, Univ Hosp Case Med Ctr, Mood & Metab Clin, Cleveland, OH 44106 USA.
C3 University of Toronto; University Health Network Toronto; University of
   Toronto; University Health Network Toronto; University of Toronto;
   Sunnybrook Health Science Center; Sunnybrook Research Institute; McGill
   University; University of Toronto; Sunnybrook Research Institute;
   Sunnybrook Health Science Center; University System of Ohio; Case
   Western Reserve University; Case Western Reserve University Hospital
RP McIntyre, RS (corresponding author), Univ Toronto, Dept Psychiat, Univ Hlth Network, Mood Disorders Psychopharmacol Unit, 399 Bathurst St,MP9-325, Toronto, ON M5T 2S8, Canada.
EM roger.mcintyre@uhn.on.ca
RI Goldstein, Benjamin/ADR-2374-2022; Taylor, Valerie/H-6242-2015;
   McIntyre, Roger/AAU-1000-2020
OI Alsuwaidan, Mohammad/0000-0003-1344-2935; Taylor,
   Valerie/0000-0002-8948-638X; Beaulieu, Serge/0000-0001-6921-3870
FU AstraZeneca; Eli Lilly and Company; Forest; Janssen-Ortho; Lundbeck;
   Pfizer; Sepracor; Shire; Bristol-Myers Squibb; Novartis; Pfizer Canada;
   Canadian Institutes of Health Research (CIHR); Biovail; Fonds de
   recherche du Quebec; Merck-Frosst; National Alliance for Research on
   Schizophrenia and Depression; Pfizer Servier; Revue Sante mentale au
   Quebec; Stanley Foundation
FX Dr. McIntyre is on advisory boards for AstraZeneca, Bristol-Myers
   Squibb, Eli Lilly and Company, Janssen-Ortho, Lundbeck, Merck, Pfizer,
   and Shire; is on speakers bureaus for AstraZeneca, Eli Lilly and
   Company, Janssen-Ortho, Lundbeck, Merck, Otsuka, and Pfizer; is involved
   in CME activities with AstraZeneca, Bristol-Myers Squibb, CME
   Outfitters, Eli Lilly and Company, Lundbeck, Merck, Otsuka, Pfizer, and
   the Physicians' Postgraduate Press; and receives research grants from
   AstraZeneca, Eli Lilly and Company, Forest, Janssen-Ortho, Lundbeck,
   Pfizer, Sepracor, and Shire. Dr. Alsuwaidan reports no financial
   relationship with any company whose products are mentioned in this
   article or with manufacturers of competing products. Dr. Goldstein
   receives grant/research support from Pfizer and is a speaker for Purdue
   Pharma. Dr. Taylor receives grant/research support from Bristol-Myers
   Squibb and Novartis, is a consultant to Bristol-Myers Squibb and Eli
   Lilly and Company, and is a speaker for Bristol-Myers Squibb, Eli Lilly
   and Company, Lundbeck, and Pfizer. Dr. Schaffer receives grant/research
   support from Pfizer Canada and the Canadian Institutes of Health
   Research (CIHR); is a consultant to AstraZeneca, Bristol-Myers Squibb,
   Eli Lilly and Company, and Lundbeck; and is a speaker for AstraZeneca,
   Bristol-Myers Squibb, and Eli Lilly and Company. Dr. Beaulieu receives
   grant/research support from AstraZeneca, Biovail, Bristol-Myers Squibb,
   the CIHR, Eli Lilly and Company, Fonds de recherche du Quebec,
   Janssen-Ortho, Lundbeck, Merck-Frosst, Novartis, the National Alliance
   for Research on Schizophrenia and Depression, Pfizer Servier, Revue
   Sante mentale au Quebec, and the Stanley Foundation; is a consultant to
   AstraZeneca, Bristol-Myers Squibb, Eli Lilly and Company,
   GlaxoSmithKline, Janssen-Ortho, Lundbeck, Oryx, Schering-Plough Merck,
   Wyeth Pfizer: and is a speaker for AstraZeneca, Biovail, Bristol-Myers
   Squibb, Eli Lilly and Company, GlaxoSmithKline, Janssen-Ortho, Lundbeck,
   Organon, Oryx, and Wyeth Pfizer. Dr. Kemp is a consultant to
   Bristol-Myers Squibb and Janssen; is a speaker for AstraZeneca and
   Pfizer; and his spouse has been a minor shareholder of sanofi-aventis
   and Abbott Laboratories within the last 12 months.
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NR 110
TC 82
Z9 90
U1 0
U2 18
PU QUADRANT HEALTHCOM INC
PI PARSIPPANY
PA 7 CENTURY DRIVE, STE 302, PARSIPPANY, NJ 07054-4603 USA
SN 1040-1237
EI 1547-3325
J9 ANN CLIN PSYCHIATRY
JI Ann. Clin. Psychiatry
PD FEB
PY 2012
VL 24
IS 1
BP 69
EP 81
PG 13
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 896OZ
UT WOS:000300579900007
PM 22303523
DA 2025-06-11
ER

PT J
AU Guo, YT
   Niu, K
   Momma, H
   Kobayashi, Y
   Chujo, M
   Otomo, A
   Fukudo, S
   Nagatomi, R
AF Guo, Yinting
   Niu, Kaijun
   Momma, Haruki
   Kobayashi, Yoritoshi
   Chujo, Masahiko
   Otomo, Atsushi
   Fukudo, Shin
   Nagatomi, Ryoichi
TI Irritable Bowel Syndrome Is Positively Related to Metabolic Syndrome: A
   Population-Based Cross-Sectional Study
SO PLOS ONE
LA English
DT Article
ID DIETARY PATTERN-ANALYSIS; GASTROINTESTINAL SYMPTOMS; PREVALENCE; FOOD;
   METAANALYSIS; ASSOCIATION; CONSUMPTION; DEPRESSION; MANAGEMENT; EXERCISE
AB Irritable bowel syndrome is a common gastrointestinal disorder that may affect dietary pattern, food digestion, and nutrient absorption. The nutrition-related factors are closely related to metabolic syndrome, implying that irritable bowel syndrome may be a potential risk factor for metabolic syndrome. However, few epidemiological studies are available which are related to this potential link. The purpose of this study is to determine whether irritable bowel syndrome is related to metabolic syndrome among middle-aged people. We designed a cross-sectional study of 1,096 subjects to evaluate the relationship between irritable bowel syndrome and metabolic syndrome and its components. Diagnosis of irritable bowel syndrome was based on the Japanese version of the Rome III Questionnaire. Metabolic syndrome was defined according to the criteria of the American Heart Association scientific statements of 2009. Dietary consumption was assessed via a validated food frequency questionnaire. Principal-components analysis was used to derive 3 major dietary patterns: "Japanese", "sweetsfruits", and "Izakaya (Japanese Pub) "from 39 food groups. The prevalence of irritable bowel syndrome and metabolic syndrome were 19.4% and 14.6%, respectively. No significant relationship was found between the dietary pattern factor score tertiles and irritable bowel syndrome. After adjustment for potential confounders (including dietary pattern), the odds ratio (95% confidence interval) of having metabolic syndrome and elevated triglycerides for subjects with irritable bowel syndrome as compared with non-irritable bowel syndrome are 2.01(1.13-3.55) and 1.50(1.03-2.18), respectively. Irritable bowel syndrome is significantly related to metabolic syndrome and it components. This study is the first to show that irritable bowel syndrome was significantly related to a higher prevalence of metabolic syndrome and elevated triglycerides among an adult population. The findings suggest that the treatment of irritable bowel syndrome may be a potentially beneficial factor for the prevention of metabolic syndrome. Further study is needed to clarify this association.
C1 [Guo, Yinting; Niu, Kaijun] Tianjin Med Univ, Nutr Epidemiol Inst, Tianjin, Peoples R China.
   [Guo, Yinting; Niu, Kaijun] Tianjin Med Univ, Sch Publ Hlth, Tianjin, Peoples R China.
   [Guo, Yinting; Fukudo, Shin] Tohoku Univ, Dept Behav Med, Grad Sch Med, Sendai, Miyagi 980, Japan.
   [Momma, Haruki; Kobayashi, Yoritoshi; Chujo, Masahiko; Otomo, Atsushi; Nagatomi, Ryoichi] Tohoku Univ, Div Biomed Engn Hlth & Welf, Grad Sch Biomed Engn, Sendai, Miyagi 980, Japan.
C3 Tianjin Medical University; Tianjin Medical University; Tohoku
   University; Tohoku University
RP Niu, K (corresponding author), Tianjin Med Univ, Nutr Epidemiol Inst, Tianjin, Peoples R China.
EM nkj0809@163.com
RI Niu, Kaijun/ADD-6222-2022; Fukudo, Shin/J-4813-2014; Nagatomi,
   Ryoichi/Q-8792-2016
OI Niu, Kaijun/0000-0002-8772-2481; Nagatomi, Ryoichi/0000-0003-3038-7202;
   Momma, Haruki/0000-0003-1134-0898
FU Ministry of Education, Culture, Sports, Science and Technology of Japan
FX This study was supported by a Grant-in-Aid for "Knowledge Cluster
   Initiative" from the Ministry of Education, Culture, Sports, Science and
   Technology of Japan. The funders had no role in study design, data
   collection and analysis, decision to publish, or preparation of the
   manuscript.
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   Yamaoka K, 2012, BMC MED, V10, DOI 10.1186/1741-7015-10-138
   Yao C K., 2013, J Hum Nutr Diet
NR 47
TC 38
Z9 44
U1 0
U2 13
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD NOV 10
PY 2014
VL 9
IS 11
AR e112289
DI 10.1371/journal.pone.0112289
PG 6
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA AT3DP
UT WOS:000344816700045
PM 25383869
OA gold, Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Wattanathorn, J
   Kawvised, S
   Thukham-mee, W
AF Wattanathorn, Jintanaporn
   Kawvised, Supannika
   Thukham-mee, Wipawee
TI Encapsulated Mulberry Fruit Extract Alleviates Changes in an Animal
   Model of Menopause with Metabolic Syndrome
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Article
ID HIGH-FAT DIET; ALBA-L. FRUIT; ANGIOTENSIN-CONVERTING ENZYME;
   ACTIVATED-RECEPTOR-GAMMA; OXIDATIVE STRESS; PPAR-GAMMA; ANTIOXIDANT
   ACTIVITIES; INSULIN-RESISTANCE; PHENOLIC-COMPOUNDS; GLYCEMIC CONTROL
AB Currently, the therapeutic strategy against metabolic syndrome and its complications is required due to the increasing prevalence and its impact. Due to the benefits of both mulberry fruit extract and encapsulation technology, we hypothesized that encapsulated mulberry fruit extract (MME) could improve metabolic parameters and its complication risk in postmenopausal metabolic syndrome. To test this hypothesis, female Wistar rats were induced experimental menopause with metabolic syndrome by bilateral ovariectomy (OVX) and high-carbohydrate high-fat (HCHF) diet. Then, they were orally given MME at doses of 10, 50, and 250 mg/kg BW for 8 weeks and the parameters, such as percentage of body weight gain, total cholesterol, triglycerides, HDL-C, LDL-C, atherogenic index, fasting blood glucose, plasma glucose area under the curve, serum angiotensin-converting enzyme (ACE), oxidative stress status, histology, and protein expression of PPAR-gamma, TNF-alpha, and NF-kappa B in adipose tissues were determined. MME improved body weight gain, adiposity index, glucose intolerance, lipid profiles, atherogenic index, ACE, oxidative stress status, and protein expression of TNF-alpha and NF-kappa B. Moreover, MME attenuated adipocyte hypertrophy and enhanced PPAR-gamma expression. Taken altogether, MME decreased metabolic syndrome and its complication via the increased PPAR-gamma expression. Therefore, MME is the potential candidate for improving metabolic syndrome and its related complications. However, further research in clinical trial is still necessary.
C1 [Wattanathorn, Jintanaporn; Kawvised, Supannika; Thukham-mee, Wipawee] Khon Kaen Univ, Fac Med, Dept Physiol, Khon Kaen 40002, Thailand.
   [Wattanathorn, Jintanaporn; Thukham-mee, Wipawee] Khon Kaen Univ, Integrat Complementary & Alternat Med Res & Dev C, Khon Kaen 40002, Thailand.
   [Wattanathorn, Jintanaporn; Thukham-mee, Wipawee] Khon Kaen Univ, Res Inst Human High Performance & Hlth Promot, Khon Kaen 40002, Thailand.
C3 Khon Kaen University; Khon Kaen University; Khon Kaen University
RP Wattanathorn, J (corresponding author), Khon Kaen Univ, Fac Med, Dept Physiol, Khon Kaen 40002, Thailand.; Wattanathorn, J (corresponding author), Khon Kaen Univ, Integrat Complementary & Alternat Med Res & Dev C, Khon Kaen 40002, Thailand.; Wattanathorn, J (corresponding author), Khon Kaen Univ, Res Inst Human High Performance & Hlth Promot, Khon Kaen 40002, Thailand.
EM jinwat05@gmail.com
RI Kawvised, Supannika/IWM-6096-2023
OI Wattanathorn, Jintanaporn/0000-0002-7383-2348
FU Integrative Complementary Alternative Medicine Research and Development
   Center at the Research Institute for Human High Performance and Health
   Promotion, Khon Kaen University, Thailand
FX This study was supported by the Integrative Complementary Alternative
   Medicine Research and Development Center at the Research Institute for
   Human High Performance and Health Promotion, Khon Kaen University,
   Thailand (Research Fund Year 2014).
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NR 72
TC 14
Z9 14
U1 1
U2 12
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PY 2019
VL 2019
AR 5360560
DI 10.1155/2019/5360560
PG 23
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA IF9XV
UT WOS:000473446700001
PM 31182993
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Isobe, A
   Shimada, T
   Aburada, M
   Yanagisawa, R
   Sakawa, T
   Nakamura, T
   Himi, T
   Ohta, R
   Kawaguchi, M
AF Isobe, Anna
   Shimada, Tsutomu
   Aburada, Masaki
   Yanagisawa, Rie
   Sakawa, Tomoyoshi
   Nakamura, Takahiro
   Himi, Toshiyuki
   Ohta, Ryo
   Kawaguchi, Maiko
TI Hatano rats are a suitable metabolic syndrome model for studying feeding
   behavior, blood pressure levels, and percent body fat
SO JOURNAL OF VETERINARY MEDICAL SCIENCE
LA English
DT Article
DE blood pressure; feeding behavior; Hatano rat; metabolic syndrome; model
   animal
ID LOW-AVOIDANCE RATS; NEUROPEPTIDE-Y; MOUSE MODEL; FOOD-INTAKE; STRESS;
   NEUROENDOCRINE; AXIS
AB Currently, metabolic syndrome is a worldwide concern. Thus, it is imperative to understand the mechanism of metabolic syndrome by establishing various metabolic syndrome models. In this study, we used Hatano high-avoidance animals (HAA) and low-avoidance animals (LAA), both derived from Sprague-Dawley rats by selective breeding to determine high-or low-avoidance rates in shuttle-box active avoidance tests. HAA and LAA rats have some strain differences related to eating and appetite. Therefore, we determined whether Hatano rats could be used as a metabolic syndrome model. We compared food intake, body weights, blood pressure levels, plasma component levels, and fat contents between HAA and LAA rats. The HAA rats showed more active eating, higher blood pressure, higher percentage fat, and higher triglyceride levels than the LAA rats-these features correspond to some of the risk factors associated with metabolic syndrome. Our study suggests that HAA rats can be considered as a metabolic syndrome model by focusing on their feeding behavior, blood pressure levels, and percent body fat.
C1 [Isobe, Anna; Kawaguchi, Maiko] Meiji Univ, Grad Sch Agr, Lab Anim Behav & Environm Sci, Tama Ku, 1-1-1 Higashimita, Kawasaki, Kanagawa 2148571, Japan.
   [Shimada, Tsutomu] Kanazawa Univ, Univ Hosp, Dept Hosp Pharm, 13-1 Takaramachi, Kanazawa, Ishikawa 9208641, Japan.
   [Shimada, Tsutomu; Aburada, Masaki; Himi, Toshiyuki; Kawaguchi, Maiko] Musashino Univ, 1-1-20 Shinmachi, Tokyo 2028585, Japan.
   [Yanagisawa, Rie] Natl Inst Environm Studies, Ctr Hlth & Environm Risk Res, 16-2 Onogawa, Tsukuba, Ibaraki 3058506, Japan.
   [Sakawa, Tomoyoshi; Nakamura, Takahiro] Teikyo Heisei Univ, Fac Pharmaceut Sci, Nakano Ku, 4-21-2 Nakano, Tokyo 1648530, Japan.
   [Ohta, Ryo] Food & Drug Safety Ctr, Hatano Res Inst, 729-5 Ochiai, Hadano, Kanagawa 2578523, Japan.
C3 Meiji University; Kanazawa University; National Institute for
   Environmental Studies - Japan
RP Kawaguchi, M (corresponding author), Meiji Univ, Grad Sch Agr, Lab Anim Behav & Environm Sci, Tama Ku, 1-1-1 Higashimita, Kawasaki, Kanagawa 2148571, Japan.; Kawaguchi, M (corresponding author), Musashino Univ, 1-1-20 Shinmachi, Tokyo 2028585, Japan.
EM maiko@meiji.ac.jp
RI Kawaguchi, Maiko/LBH-1426-2024
OI Kawaguchi, Maiko/0000-0002-3184-9483
FU Japan Society for the Promotion of Science [JP17H01888]
FX We are grateful to the staff of Meiji University and Musashino
   University for its technical assistance with the experiments. The
   authors would like to thank Dr. Iain McTaggart (School of Agriculture in
   Meiji University) for English language editing. This study was partly
   supported by Grants-in-Aid (B) (grant no. JP17H01888 to R.Y.) from the
   Japan Society for the Promotion of Science.
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NR 31
TC 0
Z9 0
U1 0
U2 5
PU JAPAN SOC VET SCI
PI TOKYO
PA UNIV TOKYO, 1-1-1 YAYOI, BUNKYO-KU, TOKYO, 103, JAPAN
SN 0916-7250
EI 1347-7439
J9 J VET MED SCI
JI J. Vet. Med. Sci.
PD JAN
PY 2019
VL 81
IS 1
BP 147
EP 154
DI 10.1292/jvms.18-0342
PG 8
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA HL2MM
UT WOS:000458539200027
PM 30464089
OA gold, Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Happell, B
   Platania-Phung, C
   Stanton, R
   Millar, F
AF Happell, Brenda
   Platania-Phung, Chris
   Stanton, Robert
   Millar, Freyja
TI Exploring the Views of Nurses on the Cardiometabolic Health Nurse in
   Mental Health Services in Australia
SO ISSUES IN MENTAL HEALTH NURSING
LA English
DT Article
ID CORONARY-HEART-DISEASE; PRIMARY-CARE ACCESS; PHYSICAL HEALTH;
   RISK-FACTORS; CARDIOVASCULAR RISK; METABOLIC SYNDROME; EXCESS MORTALITY;
   TRAINING NEEDS; MEDICAL-CARE; PEOPLE
AB People with serious mental illness experience premature death due to higher rates of cardiometabolic conditions (e.g. cardiovascular disease, diabetes) than the general population. Mental health services often do not provide sufficient cardiometabolic clinical care to address these risks. The cardiometabolic health nurse (CHN) role has been suggested as a strategy for ensuring integrated care is provided and sustained. The views of nurses in mental health would be essential in informing the viability and development for this initiative. This paper presents the findings of open-ended comments from a cross-sectional online survey of nurses working in mental health in Australia (n = 643) eliciting views about the possible introduction of the cardiometabolic nurse. Thematic analysis was undertaken, of 133 open comments on this topic. The findings suggest that nurses see the specialist role as suitable and valuable for mental health services. Some nurses voiced concern about specialisation leading to fragmentation (e.g. in responsibilities for physical health, division of mental and physical health care, and less emphasis on equipping all nurses with comprehensive care skills), especially for settings where generalist nursing was seen as already available. The findings suggest this role is viewed favourably by nurses, provided that it is consistent with holistic and comprehensive care. Empirical research is needed to see whether this role increases holism (as valued by consumers and nurses) and cardiometabolic outcomes.
C1 [Happell, Brenda; Stanton, Robert] Cent Queensland Univ, Inst Hlth & Social Sci Res, Rockhampton, Qld 4701, Australia.
   [Happell, Brenda; Stanton, Robert] Ctr Mental Hlth Nursing Innovat, Rockhampton, Qld, Australia.
   [Platania-Phung, Chris] Cent Queensland Univ, Inst Hlth & Social Sci Res, Melbourne, Vic, Australia.
   [Platania-Phung, Chris] Ctr Mental Hlth Nursing Innovat, Melbourne, Vic, Australia.
   [Millar, Freyja] Eastern Hlth, Mental Hlth Serv, Box Hill, Vic 3128, Australia.
C3 Central Queensland University; Central Queensland University; Eastern
   Health
RP Happell, B (corresponding author), Cent Queensland Univ, Sch Nursing & Midwifery, Rockhampton, Qld 4701, Australia.
EM b.happell@cqu.edu.au
RI Stanton, Rob/AAJ-5157-2020; Happell, Brenda/HSI-0570-2023
OI Happell, Brenda/0000-0002-7293-6583
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NR 57
TC 11
Z9 12
U1 0
U2 5
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 0161-2840
EI 1096-4673
J9 ISSUES MENT HEALTH N
JI Issues Ment. Health Nurs.
PD FEB
PY 2015
VL 36
IS 2
BP 135
EP 144
DI 10.3109/01612840.2014.901449
PG 10
WC Nursing; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Psychiatry
GA CG4ZI
UT WOS:000353297700009
PM 25397354
DA 2025-06-11
ER

PT J
AU Folkow, B
AF Folkow, B
TI Man's two environments and disorders of civilization: Aspects on
   prevention
SO BLOOD PRESSURE
LA English
DT Review
DE primary hypertension; metabolic syndrome; disorder of civilisation;
   environmental influences; psychosocial stress; preventive aspects
ID BLOOD-PRESSURE; SALT INTAKE; HYPERTENSION; EXERCISE; ATHEROSCLEROSIS;
   MONKEYS; STRESS
C1 Univ Gothenburg, Dept Physiol & Pharmacol, Physiol Sect, SE-41390 Gothenburg, Sweden.
C3 University of Gothenburg
RP Folkow, B (corresponding author), Univ Gothenburg, Dept Physiol & Pharmacol, Physiol Sect, SE-41390 Gothenburg, Sweden.
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NR 39
TC 13
Z9 13
U1 0
U2 1
PU TAYLOR & FRANCIS AS
PI OSLO
PA CORT ADELERSGT 17, PO BOX 2562, SOLLI, 0202 OSLO, NORWAY
SN 0803-7051
J9 BLOOD PRESSURE
JI Blood Pressure
PY 2000
VL 9
IS 4
BP 182
EP 191
DI 10.1080/080370500439065
PG 10
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 360RD
UT WOS:000089680300002
PM 11055470
OA Bronze
DA 2025-06-11
ER

PT J
AU Kinlein, SA
   Wilson, CD
   Karatsoreos, IN
AF Kinlein, Scott A.
   Wilson, Christopher D.
   Karatsoreos, Ilia N.
TI Dysregulated hypothalamic-pituitary-adrenal axis function contributes to
   altered endocrine and neurobehavioral responses to acute stress
SO FRONTIERS IN PSYCHIATRY
LA English
DT Article
DE corticosterone; allostatic load; prefrontal cortex; hippocampus; c-Fos
ID CORTICOTROPIN-RELEASING-FACTOR; EARLY GENE-EXPRESSION; HPA-AXIS;
   PARAVENTRICULAR NUCLEUS; PREFRONTAL CORTEX; GLUTAMATERGIC TRANSMISSION;
   METABOLIC SYNDROME; RESTRAINT STRESS; LOCUS-COERULEUS; FOS EXPRESSION
AB Organisms react to environmental challenges by activating a coordinated set of brain body responses known as the stress response. These physiological and behavioral countermeasures are, in large part, regulated by the neuroendocrine hypothalamic pituitary adrenal (HPA) axis. Normal functioning of the HPA axis ensures that an organism responds appropriately to altered environmental demands, representing an essential system to promote survival. Over the past several decades, increasing evidence supports the hypothesis that disruption of the HPA axis can lead to dysregulated stress response phenotypes, exacting a physiological cost on the organism commonly referred to as allostatic load. Furthermore, it has been recognized that high allostatic load can contribute to increased vulnerability of the organism to further challenges. This observation leads to the notion that disrupted HPA function and resulting inappropriate responses to stressors may underlie many neuropsychiatric disorders, including depression and anxiety. In the present set of studies, we investigate the role of both the normally functioning and disrupted HPA axis in the endocrine, neural, and behavioral responses to acute stress. Using a model of non-invasive chronic corticosterone treatment in mice, we show that dysregulating the normal function of the HPA leads to a mismatch between the hormonal and neural response to acute stress, resulting in abnormal behavioral coping strategies. We believe this model can be leveraged to tease apart the mechanisms by which altered HPA function contributes to neurobehavioral dysregulation in response to acute stress.
C1 [Kinlein, Scott A.; Wilson, Christopher D.; Karatsoreos, Ilia N.] Washington State Univ, Dept Integrat Physiol & Neurosci, Pullman, WA 99164 USA.
C3 Washington State University
RP Karatsoreos, IN (corresponding author), Washington State Univ, Dept Integrat Physiol & Neurosci, 1815 Ferdinands Lane, Pullman, WA 99164 USA.
EM iliak@vetmed.wsu.edu
RI Karatsoreos, Ilia/AAR-8774-2020
OI Kinlein, Scott/0000-0002-5093-2127; Wilson,
   Christopher/0000-0002-2744-4205
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NR 64
TC 93
Z9 106
U1 0
U2 8
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-0640
J9 FRONT PSYCHIATRY
JI Front. Psychiatry
PD MAR 13
PY 2015
VL 6
AR 31
DI 10.3389/fpsyt.2015.00031
PG 9
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA CV4BU
UT WOS:000364211200001
PM 25821436
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Gottlieb, AB
   Chao, C
   Dann, F
AF Gottlieb, Alice B.
   Chao, Chun
   Dann, Frank
TI Psoriasis comorbidities
SO JOURNAL OF DERMATOLOGICAL TREATMENT
LA English
DT Review
DE cardiovascular disease; comorbidities; metabolic syndrome; obesity;
   psoriasis
ID QUALITY-OF-LIFE; NECROSIS-FACTOR-ALPHA; LOW-DENSITY-LIPOPROTEIN;
   C-REACTIVE PROTEIN; MIDDLE-AGED MEN; IMPROVES ENDOTHELIAL FUNCTION;
   RHEUMATOID-ARTHRITIS PATIENTS; ATHEROGENIC LIPID PROFILE;
   PLACEBO-CONTROLLED TRIAL; POPULATION-BASED COHORT
AB Psoriasis is a chronic and debilitating inflammatory disease associated with serious comorbidities. Psoriasis can have a significant impact on a patient's quality of life and is associated with loss of productivity, depression, and an increased prevalence of malignancy. Emerging comorbidities of psoriasis include cardiovascular disease and metabolic syndrome. Psoriasis patients have an increased prevalence of the core components of metabolic syndrome, including obesity, dyslipidemia, and insulin resistance. The relationship between psoriasis and comorbidities such as metabolic syndrome and cardiovascular disease is likely linked to the underlying chronic inflammatory nature of psoriasis. The molecular mechanisms involved in psoriasis-associated dysregulation of metabolic function are believed to be due, in large part, to the action of increased levels of proinflammatory factors, such as tumor necrosis factor-alpha, that are central to the pathogenesis of psoriasis. Recent studies investigating the effects of tumor necrosis factor antagonists on the treatment of cardiovascular disease and metabolic syndrome support this concept.
C1 [Gottlieb, Alice B.] Tufts Univ, New England Med Ctr, Boston, MA 02111 USA.
   [Chao, Chun] Univ Calif Los Angeles, Dept Epidemiol, Los Angeles, CA USA.
   [Dann, Frank] Amgen Inc, Thousand Oaks, CA 91320 USA.
C3 Tufts Medical Center; Tufts University; University of California System;
   University of California Los Angeles; Amgen
RP Gottlieb, AB (corresponding author), Tufts Univ, New England Med Ctr, 750 Washington St,Box 114, Boston, MA 02111 USA.
EM agottlieb@tufts-nemc.org
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   2002, CIRCULATION, V3143, P106
NR 209
TC 202
Z9 215
U1 0
U2 16
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0954-6634
EI 1471-1753
J9 J DERMATOL TREAT
JI J. Dermatol. Treat.
PY 2008
VL 19
IS 1
BP 5
EP 21
DI 10.1080/09546630701364768
PG 17
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 262AX
UT WOS:000253122500002
PM 18273720
DA 2025-06-11
ER

PT J
AU Mitra, A
   Crump, EM
   Alvers, KM
   Robertson, KL
   Rowland, NE
AF Mitra, A.
   Crump, E. M.
   Alvers, K. M.
   Robertson, K. L.
   Rowland, N. E.
TI Effect of high-fat diet on stress responsiveness in borderline
   hypertensive rats
SO STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS
LA English
DT Article
DE blood pressure; fetal programing; junk food; metabolic syndrome;
   borderline hypertensive rat; psychosocial stress; social defeat
ID INDUCED INSULIN-SECRETION; JUNK FOOD DIET; BLOOD-PRESSURE; INDUCED
   OBESITY; PSYCHOLOGICAL STRESS; PANCREATIC-ISLETS; OXIDATIVE STRESS;
   SOCIAL STRESS; PROTEIN-DIET; LEPTIN
AB Stress in combination with genetic susceptibility is a factor in the development of hypertension. We used borderline hypertensive rats to investigate whether exposure to high-fat and/or junk-food diet at different stages of ontogeny has programing consequences on stress responses. Wistar dams were fed a high- or low-fat diet for 6 weeks prior to mating with spontaneously hypertensive males, and during gestation. At birth, litters were fostered either to a dam in the same or an alternative diet condition as during gestation. After weaning, male offspring were fed either a control-chow diet or an intermittent junk food fatty diet. Between postnatal days 57-61, half of the rats in each dietary group received daily social defeat sessions using a resident-intruder protocol, and the other half were unstressed controls. Blood pressure was measured indirectly both before and after each defeat session. On the final day, rats were killed for physiological measures. Socially defeated rats showed large increases in serum corticosterone concentration and adrenal hypertrophy, indicating the effectiveness of this non-adapting stressor. Serum corticosterone level was also higher in rats fed with the junk-food diet post-weaning compared with those fed with chow only, but there were no significant effects of gestational or lactational dietary history.
C1 [Mitra, A.; Crump, E. M.; Alvers, K. M.; Robertson, K. L.; Rowland, N. E.] Univ Florida, Dept Psychol, Gainesville, FL 32611 USA.
C3 State University System of Florida; University of Florida
RP Mitra, A (corresponding author), Univ Florida, Dept Psychol, Gainesville, FL 32611 USA.
EM amitra@umn.edu
FU NIH [DK064712]; American Psychological Association
FX Supported in part by NIH grant DK064712 and by a dissertation grant
   award to A. M. from the American Psychological Association.
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NR 52
TC 4
Z9 4
U1 0
U2 5
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1025-3890
EI 1607-8888
J9 STRESS
JI Stress
PD JAN
PY 2011
VL 14
IS 1
BP 42
EP 52
DI 10.3109/10253890.2010.494746
PG 11
WC Behavioral Sciences; Endocrinology & Metabolism; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Behavioral Sciences; Endocrinology & Metabolism; Neurosciences &
   Neurology
GA 696DP
UT WOS:000285422400006
PM 20666663
DA 2025-06-11
ER

PT J
AU Montemayor, S
   Mascaró, CM
   Ugarriza, L
   Casares, M
   Gómez, C
   Martínez, JA
   Tur, JA
   Bouzas, C
AF Montemayor, Sofia
   Mascaro, Catalina M.
   Ugarriza, Lucia
   Casares, Miguel
   Gomez, Cristina
   Alfredo Martinez, J.
   Tur, Josep A.
   Bouzas, Cristina
TI Intrahepatic Fat Content and COVID-19 Lockdown in Adults with NAFLD and
   Metabolic Syndrome
SO NUTRIENTS
LA English
DT Article
DE COVID-19; lockdown; NAFLD; intrahepatic fat content; metabolic syndrome;
   dietary habits
ID LIVER-DISEASE; OXIDATIVE STRESS; NONALCOHOLIC STEATOHEPATITIS; DARK
   CHOCOLATE; CONSUMPTION; RISK; METAANALYSIS; POPULATION; CAFFEINE; COFFEE
AB Background: COVID-19 lockdowns had a significant impact on people's health, triggering levels of anxiety, perceived stress, and changes in food and nutritional status. Objectives: To assess the changes in dietary habits, metabolic syndrome (MetS) and liver parameters before and after the COVID-19 lockdown according to changes in intrahepatic fat content in adults with non-alcoholic fatty liver disease (NAFLD) and MetS. Design: Pre- and post-lockdown observation of the COVID-19 lockdown on fifty-nine 40-60-year-old participants with MetS and NAFLD, in a parallel group, randomised experiment intended to treat NAFLD. Methods: Anthropometrics, liver and MetS biochemical parameters, intrahepatic fat content by abdominal magnetic resonance imaging, and dietary assessment using a validated 148-item Food Frequency Questionnaire were collected pre-COVID-19 lockdown and post-lockdown. Results: COVID-19 lockdown led to negative changes in the liver of patients with NAFLD and MetS, with weight gain and increases in glycemia, ALT and intrahepatic fat content post lockdown. Participants with worsened liver status had low consumption of fibre, cheese, nuts and coffee, and high consumption of sweets and pastries. Participants who improved liver status ameliorated ALT values, waist circumference, and intrahepatic fat content, assessed by magnetic resonance imaging post-lockdown. Conclusions: The maintenance of healthy lifestyle habits is vital, especially for populations with NAFLD and MetS, to reduce unhealthy lifestyle patterns displayed during lockdown.
C1 [Montemayor, Sofia; Mascaro, Catalina M.; Ugarriza, Lucia; Gomez, Cristina; Tur, Josep A.; Bouzas, Cristina] Univ Balearic Isl IUNICS, Res Grp Community Nutr & Oxidat Stress, Palma De Mallorca 07122, Spain.
   [Montemayor, Sofia; Mascaro, Catalina M.; Ugarriza, Lucia; Gomez, Cristina; Tur, Josep A.; Bouzas, Cristina] Hlth Inst Balearic Isl IDISBA, Palma De Mallorca 07120, Spain.
   [Ugarriza, Lucia] Camp Redo Primary Hlth Care Ctr, Palma De Mallorca 07010, Spain.
   [Casares, Miguel] Red Asistencial Juaneda, Radiodiag Serv, Palma De Mallorca 07011, Spain.
   [Gomez, Cristina] Univ Hosp Son Espases, Clin Anal Serv, Palma De Mallorca 07120, Spain.
   [Alfredo Martinez, J.] Univ Navarra, Ctr Nutr Res, Dept Nutr Food Sci & Physiol, Pamplona 31008, Spain.
   [Alfredo Martinez, J.] CEI UAM CSIC, IMDEA Food, Cardiomet Precis Nutr Program, Madrid 28049, Spain.
   [Tur, Josep A.; Bouzas, Cristina] Inst Salud Carlos III ISCIII, CIBEROBN Physiopathol Obes & Nutr CB12 03 30038, Madrid 28029, Spain.
C3 Hospital Universitari Son Espases; University of Navarra; Consejo
   Superior de Investigaciones Cientificas (CSIC); IMDEA Food Institute;
   CIBER - Centro de Investigacion Biomedica en Red; CIBEROBN
RP Tur, JA (corresponding author), Univ Balearic Isl IUNICS, Res Grp Community Nutr & Oxidat Stress, Palma De Mallorca 07122, Spain.; Tur, JA (corresponding author), Hlth Inst Balearic Isl IDISBA, Palma De Mallorca 07120, Spain.; Tur, JA (corresponding author), Inst Salud Carlos III ISCIII, CIBEROBN Physiopathol Obes & Nutr CB12 03 30038, Madrid 28029, Spain.
EM pep.tur@uib.es
RI Martínez, J./K-8709-2014; Tur, Josep/AAE-5748-2020; Bouzas,
   Cristina/AAE-2069-2019; Tur, Josep/F-5576-2014
OI GOMEZ COBO, CRISTINA/0000-0002-9776-4730; Montemayor,
   Sofia/0000-0001-7833-2118; Tur, Josep/0000-0002-6940-0761; Bouzas
   Velasco, Cristina/0000-0002-1407-8461
FU Fundacio La Marato TV3 (Spain) project [201630.10]; Instituto de Salud
   Carlos III through the CIBEROBN [CB12/03/30038]; Proyecto Intramural
   CIBER - European Regional Development Fund [OBN18PI03]; Spanish Ministry
   of Education; Spanish Agency of Research (MCINN)
FX Fundacio La Marato TV3 (Spain) project ref. 201630.10. Instituto de
   Salud Carlos III through the CIBEROBN CB12/03/30038, and Proyecto
   Intramural CIBER OBN18PI03, which are co-funded by the European Regional
   Development Fund. Other funding received: IDISBA grants (FOLIUM, PRIMUS,
   SYNERGIA, and LIBERI). C.M.M. received an FPU PhD grant from the
   SpanishMinistry of Education. C.B. received aMargalida Comas
   post-doctoral grant from the Spanish Agency of Research (MCINN). The
   funding sponsors had no role in the design of the study; in the
   collection, analyses, or interpretation of the data; in the writing of
   the manuscript; or in the decision to publish the results.
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NR 73
TC 5
Z9 5
U1 1
U2 4
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD SEP
PY 2022
VL 14
IS 17
AR 3462
DI 10.3390/nu14173462
PG 14
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 4K4DR
UT WOS:000851903100001
PM 36079720
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Honkalampi, K
   Viinamäki, H
   Niskanen, L
   Koivumaa-Honkanen, H
   Valkonen-Korhonen, M
   Elomaa, AP
   Harvima, I
   Herzig, KH
   Lehto, SM
AF Honkalampi, Kirsi
   Viinamaki, Heimo
   Niskanen, Leo
   Koivumaa-Honkanen, Heli
   Valkonen-Korhonen, Minna
   Elomaa, Antti-Pekka
   Harvima, Ilkka
   Herzig, Karl-Heinz
   Lehto, Soili M.
TI Reduced Serum Adiponectin Levels in Alexithymia
SO NEUROIMMUNOMODULATION
LA English
DT Article
DE Alexithymia; Depression; Immune systems
ID METABOLIC SYNDROME; INFLAMMATION; DEPRESSION; ASSOCIATION; STABILITY;
   SYMPTOMS; TISSUE
AB Objectives: Clinical studies have demonstrated that circulating cytokine profiles may differ between alexithymic and non-alexithymic subjects. We examined whether the levels of adiponectin (mu g/ml) and resistin (ng/ml) are independently related to alexithymic features in a population-based sample. Methods: In 2005, clinical data including laboratory assessments were obtained from a sub-sample (n = 308) of the Kuopio Depression Study general population study including subjects aged 25-64 years. Based on the Toronto Alexithymia Scale score in 1998, 1999, 2001 and 2005, a group of subjects with high alexithymic features (n = 85) was formed and compared with non-alexithymic controls (n = 206). Results: Serum adiponectin levels were significantly lower in subjects with alexithymic features than in non-alexithymic control subjects. No difference was found in resistin levels. Similarly, in a logistic regression model adjusted for age, gender and body mass index (BMI), lowered levels of adiponectin, but not resistin, were associated with an increased likelihood of belonging to the group with alexithymic features. Further adjustments for cardiovascular risk factors (i.e. smoking, BMI, metabolic syndrome, alcohol use, and coronary heart disease), depressive symptoms (Hamilton Depression Rating Scale with 17 items) and the use of antidepressants in addition to age and gender did not change these patterns. Conclusions: Our findings suggest that a disturbed anti-inflammatory balance may characterize alexithymia. In addition, our results widen the concept of alexithymia and highlight the role of immune system alterations and stress in alexithymic individuals. (C) 2014 S. Karger AG, Basel
C1 [Honkalampi, Kirsi] Univ Eastern Finland, Dept Educ & Psychol, FI-80100 Joensuu, Finland.
   [Viinamaki, Heimo; Koivumaa-Honkanen, Heli; Valkonen-Korhonen, Minna; Elomaa, Antti-Pekka; Herzig, Karl-Heinz; Lehto, Soili M.] Kuopio Univ Hosp, Dept Psychiat, SF-70210 Kuopio, Finland.
   [Viinamaki, Heimo; Koivumaa-Honkanen, Heli; Valkonen-Korhonen, Minna; Elomaa, Antti-Pekka; Herzig, Karl-Heinz; Lehto, Soili M.] Univ Eastern Finland, Inst Clin Med Psychiat, Kuopio, Finland.
   [Niskanen, Leo] Finnish Med Agcy, Kuopio, Finland.
   [Niskanen, Leo] Univ Eastern Finland, Fac Hlth Sci, Kuopio, Finland.
   [Harvima, Ilkka] Kuopio Univ Hosp, Dept Dermatol, SF-70210 Kuopio, Finland.
   [Harvima, Ilkka] Univ Eastern Finland, Kuopio, Finland.
   [Herzig, Karl-Heinz] Univ Oulu, Med Res Ctr Oulu, Inst Biomed, Div Physiol, Oulu, Finland.
   [Herzig, Karl-Heinz] Univ Oulu, Med Res Ctr Oulu, Bioctr Oulu, Oulu, Finland.
   [Herzig, Karl-Heinz] Oulu Univ Hosp, Oulu, Finland.
C3 University of Eastern Finland; Kuopio University Hospital; University of
   Eastern Finland; University of Eastern Finland Hospital; University of
   Eastern Finland; University of Eastern Finland; Kuopio University
   Hospital; University of Eastern Finland; University of Eastern Finland
   Hospital; University of Eastern Finland; University of Oulu; University
   of Oulu; University of Oulu
RP Honkalampi, K (corresponding author), Univ Eastern Finland, Dept Educ & Psychol, POB 111, FI-80100 Joensuu, Finland.
EM kirsi.honkalampi@uef.fi
RI Koivumaa-Honkanen, Heli/L-1274-2015; Harvima, Ilkka/ITT-4403-2023
OI Lehto, Soili/0000-0003-4324-6679
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NR 37
TC 5
Z9 6
U1 0
U2 5
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1021-7401
EI 1423-0216
J9 NEUROIMMUNOMODULAT
JI Neuroimmunomodulation
PY 2014
VL 21
IS 5
BP 234
EP 239
DI 10.1159/000357051
PG 6
WC Endocrinology & Metabolism; Immunology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Immunology; Neurosciences & Neurology
GA AI5FI
UT WOS:000336890400003
PM 24603661
DA 2025-06-11
ER

PT J
AU Csongová, M
   Scheijen, JLJM
   van de Waarenburg, MPH
   Gurecká, R
   Koborová, I
   Tábi, T
   Szökö, É
   Schalkwijk, CG
   Sebeková, K
AF Csongova, Melinda
   Scheijen, Jean L. J. M.
   van de Waarenburg, Marjo P. H.
   Gurecka, Radana
   Koborova, Ivana
   Tabi, Tamas
   Szoko, Eva
   Schalkwijk, Casper G.
   Sebekova, Katarina
TI Association of α-Dicarbonyls and Advanced Glycation End Products with
   Insulin Resistance in Non-Diabetic Young Subjects: A Case-Control Study
SO NUTRIENTS
LA English
DT Article
DE advanced glycation end products; alpha-dicarbonyls; D-lactate;
   cardiometabolic risk; insulin resistance; sex differences; sRAGE; sVAP-1
ID OXIDATIVE STRESS; SOLUBLE RAGE; GLUCOSE-METABOLISM; CENTRAL OBESITY;
   RECEPTOR; PLASMA; INDIVIDUALS; ENDPRODUCTS; SENSITIVITY; CELL
AB alpha-Dicarbonyls and advanced glycation end products (AGEs) may contribute to the pathogenesis of insulin resistance by a variety of mechanisms. To investigate whether young insulin-resistant subjects present markers of increased dicarbonyl stress, we determined serum alpha-dicarbonyls-methylglyoxal, glyoxal, 3-deoxyglucosone; their derived free- and protein-bound, and urinary AGEs using the UPLC/MS-MS method; soluble receptors for AGEs (sRAGE), and cardiometabolic risk markers in 142 (49% females) insulin resistant (Quantitative Insulin Sensitivity Check Index (QUICKI) <= 0.319) and 167 (47% females) age-, and waist-to-height ratio-matched insulin-sensitive controls aged 16-to-22 years. The between-group comparison was performed using the two-factor (sex, presence/absence of insulin resistance) analysis of variance; multiple regression via the orthogonal projection to latent structures model. In comparison with their insulin-sensitive peers, young healthy insulin-resistant individuals without diabetes manifest alterations throughout the alpha-dicarbonyls-AGEs-sRAGE axis, dominated by higher 3-deoxyglucosone levels. Variables of alpha-dicarbonyls-AGEs-sRAGE axis were associated with insulin sensitivity independently from cardiometabolic risk markers, and sex-specifically. Cleaved RAGE associates with QUICKI only in males; while multiple alpha-dicarbonyls and AGEs independently associate with QUICKI particularly in females, who displayed a more advantageous cardiometabolic profile compared with males. Further studies are needed to elucidate whether interventions alleviating dicarbonyl stress ameliorate insulin resistance.
C1 [Csongova, Melinda; Gurecka, Radana; Koborova, Ivana; Sebekova, Katarina] Comenius Univ, Med Fac, Inst Mol Biomed, Bratislava 81107, Slovakia.
   [Scheijen, Jean L. J. M.; van de Waarenburg, Marjo P. H.; Schalkwijk, Casper G.] Maastricht Univ, Med Ctr, Dept Internal Med, NL-6200 MD Maastricht, Netherlands.
   [Gurecka, Radana] Comenius Univ, Fac Med, Inst Med Phys Biophys Informat & Telemed, Bratislava 81372, Slovakia.
   [Tabi, Tamas; Szoko, Eva] Semmelweis Univ, Fac Pharm, Dept Pharmacodynam, H-1089 Budapest, Hungary.
C3 Comenius University Bratislava; Maastricht University; Comenius
   University Bratislava; Semmelweis University
RP Sebeková, K (corresponding author), Comenius Univ, Med Fac, Inst Mol Biomed, Bratislava 81107, Slovakia.
EM kata.sebekova@gmail.com
RI Scheijen, Jean/AAY-3799-2020; Csongová, Melinda/AAJ-8811-2020; Sebekova,
   Katarina/GSD-7056-2022; Gurecka, Radana/AAX-6744-2021; Tábi,
   Tamás/O-2960-2017
OI Scheijen, Jean/0000-0002-1268-2286; Schalkwijk, Casper
   G/0000-0003-0190-2690
FU Slovak Research and Development Agency [0447-12]; Visegrad/V4EaP
   Scholarship [51400162]; Association for Regional Cooperation in the
   Fields of Health, Science and Technology (RECOOP HST Association);
   European Association for the Study of Diabetes [94766]; Bratislava
   Self-governing Region
FX This study was supported by grants from the Slovak Research and
   Development Agency No. 0447-12 (to KS); from the Visegrad/V4EaP
   Scholarship No. 51400162 and the Association for Regional Cooperation in
   the Fields of Health, Science and Technology (RECOOP HST Association)
   (to IK); from ARTF grant No. 94766 from the European Association for the
   Study of Diabetes (MC); and from Bratislava Self-governing Region. The
   funders had no role in the study design, data analysis, decision to
   publish, or preparation of the manuscript.
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NR 67
TC 8
Z9 8
U1 2
U2 7
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD NOV
PY 2022
VL 14
IS 22
AR 4929
DI 10.3390/nu14224929
PG 14
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 6K5VV
UT WOS:000887570300001
PM 36432614
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Hamlin, HJ
AF Hamlin, Heather J.
TI Prenatal Stress and Development: Beyond The Single Cause and Effect
   Paradigm
SO BIRTH DEFECTS RESEARCH PART C-EMBRYO TODAY-REVIEWS
LA English
DT Review
DE development; stress; endocrine disruption; environmental contaminants;
   epigenetic programming
ID ENDOCRINE-DISRUPTING CHEMICALS; THYROID-HORMONE DISRUPTION;
   POLYCHLORINATED-BIPHENYLS; METABOLIC SYNDROME; MATERNAL STRESS;
   IN-UTERO; 11-BETA-HYDROXYSTEROID DEHYDROGENASE; ORGANOCHLORINE
   PESTICIDES; PSYCHOSOCIAL STRESS; POTENTIAL INFLUENCE
AB Our awareness of the causes of stress-induced developmental dysfunction has increased dramatically over the past decade, and it is becoming increasingly clear that a number of factors can have considerable impacts on the developing fetus. Although there is a tendency in investigations of developmental teratogens to attribute specific causes to adverse fetal outcomes, it is important we recognize that for most developmental dysfunctions it is unlikely a single cause, but yet a series of environmental insults combined with genetic predisposition that ultimately leads to a disease state. Nonetheless, a number of developmental teratogens, such as maternal psychological stress and chemical exposures, have been shown to increase the likelihood of developmental defects. These defects can manifest during development, leading to observable birth defects, or could become evident long after birth, even into adulthood. In addition, epigenetic mutations in the germline can alter the phenotype of successive generations through transgenerational inheritance, and in this way environmental factors can alter the developmental outcomes and disease predispositions of future generations. Understanding this complexity is essential to interpretations of causality in the studies of stress-induced developmental dysfunction and needs to be fully considered to more effectively interpret potential outcomes. Birth Defects Research (Part C) 96:289298, 2012. (c) 2013 Wiley Periodicals, Inc.
C1 Univ Maine, Sch Marine Sci, Orono, ME USA.
C3 University of Maine System; University of Maine Orono
RP Hamlin, HJ (corresponding author), Univ Maine, Sch Marine Sci, Orono, ME USA.
EM heather.hamlin@maine.edu
RI Hamlin, Heather/K-6235-2019
OI Hamlin, Heather/0000-0002-9042-5509
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NR 110
TC 3
Z9 4
U1 0
U2 34
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1542-975X
EI 1542-9768
J9 BIRTH DEFECTS RES C
JI Birth Defects Res. Part C-Embryo Today-Rev.
PD DEC
PY 2012
VL 96
IS 4
BP 289
EP 298
DI 10.1002/bdrc.21023
PG 10
WC Developmental Biology; Reproductive Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Developmental Biology; Reproductive Biology
GA 080BF
UT WOS:000314215500002
PM 24203918
DA 2025-06-11
ER

PT J
AU Dimitratos, SM
   Hercules, M
   Stephensen, CB
   Cervantes, E
   Laugero, KD
AF Dimitratos, Sarah M.
   Hercules, Melanie
   Stephensen, Charles B.
   Cervantes, Eduardo
   Laugero, Kevin D.
TI Association between physiological stress load and diet quality patterns
   differs between male and female adults
SO PHYSIOLOGY & BEHAVIOR
LA English
DT Article
DE Diet quality; Allostatic load; Dietary guidelines; Stress; Healthy
   eating index; Sex differences
ID ALLOSTATIC LOAD; PSYCHOLOGICAL STRESS; METABOLIC SYNDROME; RISK;
   PATHOPHYSIOLOGY; BRAIN; HABIT; VIEW; SEX; AGE
AB A promising, yet relatively unexplored factor that may influence a person's stress response, is diet. Diet can affect the physiological response to stress, but relationships between diet quality and the chronic stress marker allostatic load (AL) are insufficiently studied. Furthermore, sex, age, and BMI may interact with diet quality to influence AL. 358 adults were recruited across predetermined sex, age, and BMI ranges. Cluster analysis of 13 Healthy Eating Index (HEI) sub-scores across all participants revealed six distinct diet quality patterns (HEI-P). We found sex and HEI-P interacted (PHEIxSex = 0.0232) to affect AL, reflecting a significantly different AL between women and men consuming a diet more closely aligned with the Dietary Guidelines for Americans for dairy, refined grains, and sodium consumption, but less aligned for added sugar, saturated fat, and fruits/vegetables intake. Sex and HEI-P also interacted to affect cholesterol (PHEIxSex = 0.0157), norepinephrine (PHEIxSex = 0.0315), epinephrine (PHEIxSex = 0.0204), and systolic blood pressure (PHEIxSex = 0.0457) but, compared to total allostatic load, no individual component of this biomarker explained the entire array of sex by HEI-P interactions. Our results suggest that differences in HEI-P and sex interact to influence physiological stress load which, in turn, may help resolve discrepancies in diet and sex-related disease risk.
C1 [Dimitratos, Sarah M.; Hercules, Melanie; Laugero, Kevin D.] USDA ARS, Obes & Metab Res Unit, Western Human Nutr Res Ctr, Davis, CA 95616 USA.
   [Dimitratos, Sarah M.; Stephensen, Charles B.; Cervantes, Eduardo; Laugero, Kevin D.] Univ Calif Davis, Dept Nutr, Davis, CA 95616 USA.
   [Stephensen, Charles B.] USDA ARS, Immun & Dis Prevent Res Unit, Western Human Nutr Res Ctr, Davis, CA 95616 USA.
   [Cervantes, Eduardo] USDA ARS, Human Studies Unit, Western Human Nutr Res Ctr 2, Davis, CA 95616 USA.
C3 United States Department of Agriculture (USDA); University of California
   System; University of California Davis; United States Department of
   Agriculture (USDA); United States Department of Agriculture (USDA)
RP Laugero, KD (corresponding author), USDA ARS, WHNRC, Western Human Nutr Res Ctr, Washington, DC 20250 USA.
EM smdimitratos@ucdavis.edu; mhercules@ucdavis.edu;
   Charles.stephenson@usda.gov; ecervantes@usda.gov; kevin.laugero@usda.gov
RI Stephensen, Charles/AAF-1742-2021
FU USDA Agricultural Research Service project [2032-51530-022-00-D,
   2032-51530-025-00-D]; National Center for Advancing Translational
   Sciences; National Institutes of Health [UL1 TR001860]
FX This research was supported with funding from a USDA Agricultural
   Research Service project (No.: 2032-51530-022-00-D and No.
   2032-51530-025-00-D) , as well as the National Center for Advancing
   Trans-lational Sciences and National Institutes of Health through a
   grant, UL1 TR001860. The content is solely the responsibility of the
   authors anddoes not necessarily represent the official views of the USDA
   or NIH.
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NR 39
TC 14
Z9 16
U1 0
U2 10
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0031-9384
EI 1873-507X
J9 PHYSIOL BEHAV
JI Physiol. Behav.
PD OCT 15
PY 2021
VL 240
AR 113538
DI 10.1016/j.physbeh.2021.113538
EA JUL 2021
PG 9
WC Psychology, Biological; Behavioral Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Behavioral Sciences
GA US4GA
UT WOS:000697388700004
PM 34314759
OA Bronze
DA 2025-06-11
ER

PT J
AU Knight, M
   Bolton, P
   Kopeski, L
AF Knight, Margaret
   Bolton, Paula
   Kopeski, Lynne
TI Providing Physical Care to Persons With Serious Mental Illness:
   Attitudes, Confidence, Barriers and Psychological Empowerment
SO ARCHIVES OF PSYCHIATRIC NURSING
LA English
DT Article
ID HEALTH-SERVICE USERS; NURSES PERCEPTIONS; METABOLIC SYNDROME; PEOPLE;
   NEEDS; ANTIPSYCHOTICS; ENGAGEMENT; KNOWLEDGE; INQUIRY; IMPACT
AB The prevalence of metabolic syndrome (MetS) in people with serious mental illness (SMI) has been well documented in the mental health literature. Despite the adoption of various guidelines for monitoring risk factors for diabetes and cardiovascular risk in this population, limited translation has occurred in actual practice (Hermes, Sernyak, & Rosenheck, 2013). The Institute of Medicine (IoM) (2009) has noted a lag time in the application of knowledge within clinical settings. Evidence-based practice was deemed as a means of improving healthcare outcomes through the use of science supported standards of care. Evidence-based practice (EBP) is a process to guide clinical decision making that involves the clinician's experience, well documented research findings, and the patient's values and choices (Sackett, Rosenberg, Gray, Haynes, & Richardson, 1996). The loM has established that by the year 2020, 90% of clinical decisions should be based upon current and scientifically based information (IoM, 2009). Psychiatric-mental health nurses are challenged to utilize EBP for clients with MetS in assessing their health status and discussing the findings, educating them about their current risk and life style modifications to mitigate risk, and finally, partnering with them to maximize health and quality of life. (C) 2017 Elsevier Inc. All rights reserved.
C1 [Knight, Margaret] Univ Massachusetts Lowell, Sch Nursing, Lowell, MA 01854 USA.
   [Bolton, Paula] McLean Hosp, Psychiat Neurotherapeut Program, 115 Mill St, Belmont, MA 02178 USA.
   [Kopeski, Lynne] McLean Hosp, Behav Hlth Partial Hosp Program, 115 Mill St, Belmont, MA 02178 USA.
C3 University of Massachusetts System; University of Massachusetts Lowell;
   Harvard University; Harvard University Medical Affiliates; McLean
   Hospital; Harvard University; Harvard University Medical Affiliates;
   McLean Hospital
RP Knight, M (corresponding author), Univ Massachusetts Lowell, Sch Nursing, Lowell, MA 01854 USA.
EM margaret_knight@uml.edu
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NR 45
TC 13
Z9 16
U1 0
U2 23
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0883-9417
EI 1532-8228
J9 ARCH PSYCHIAT NURS
JI Arch. Psychiatr. Nurs.
PD OCT
PY 2017
VL 31
IS 5
BP 447
EP 453
DI 10.1016/j.apnu.2017.07.001
PG 7
WC Nursing; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Psychiatry
GA FI3ZS
UT WOS:000411909500004
PM 28927507
DA 2025-06-11
ER

PT J
AU Vancampfort, D
   Probst, M
   Scheewe, T
   De Herdt, A
   Sweers, K
   Knapen, J
   van Winkel, R
   De Hert, M
AF Vancampfort, Davy
   Probst, Michel
   Scheewe, Thomas
   De Herdt, Amber
   Sweers, Kim
   Knapen, Jan
   van Winkel, Ruud
   De Hert, Marc
TI Relationships between physical fitness, physical activity, smoking and
   metabolic and mental health parameters in people with schizophrenia
SO PSYCHIATRY RESEARCH
LA English
DT Article
DE Physical fitness; Physical activity; Smoking; Mental health; Metabolic
   syndrome; Schizophrenia
ID SCHIZOAFFECTIVE DISORDER; CARDIORESPIRATORY FITNESS;
   CARDIOVASCULAR-DISEASE; SPECTRUM DISORDERS; RISK; VALIDATION; MORTALITY;
   EXERCISE; ADULTS; RELIABILITY
AB Low physical fitness has been recognised as a prominent behavioural risk factor for cardiovascular diseases (CVD) and metabolic syndrome (MetS), and as an independent risk factor for all-cause mortality. No studies have systematically assessed physical fitness compared with a matched health control group in patients with schizophrenia. Eighty patients with schizophrenia and 40 age-, gender- and body mass index (BMI)-matched healthy volunteers were included. All participants performed an Eurofit test battery and filled out the International Physical Activity Questionnaire. Patients additionally had a fasting metabolic laboratory screening and were assessed for psychiatric symptoms. Patients with schizophrenia demonstrated significant differences from controls in whole body balance, explosive leg muscle strength, abdominal muscular endurance, and running speed. Inactive patients scored worse on most Eurofit items than patients walking for at least 30 min per day. Low physical fitness was associated with illness duration, smoking, the presence of MetS and more severe negative, depressive and cognitive symptoms. Less physically active patients who smoke and suffer from high levels of negative, depressive and/or cognitive symptoms might benefit from specific rehabilitation interventions aimed at increasing physical fitness. (c) 2012 Elsevier Ireland Ltd. All rights reserved.
C1 [Vancampfort, Davy; Probst, Michel; Sweers, Kim; Knapen, Jan; van Winkel, Ruud; De Hert, Marc] Katholieke Univ Leuven, Univ Psychiat Ctr, B-3070 Kortenberg, Belgium.
   [Vancampfort, Davy; Probst, Michel; De Herdt, Amber; Knapen, Jan] Katholieke Univ Leuven, Fac Kinesiol & Rehabil Sci, Heverlee, Belgium.
   [Scheewe, Thomas] Univ Med Ctr Utrecht, Utrecht, Netherlands.
   [van Winkel, Ruud] Maastricht Univ, South Limburg Mental Hlth Res & Teaching Network, Dept Psychiat & Neuropsychol, EURON,Med Ctr, Maastricht, Netherlands.
   [De Hert, Marc] Katholieke Univ Leuven, Fac Med, Louvain, Belgium.
C3 KU Leuven; KU Leuven; Utrecht University; Utrecht University Medical
   Center; Maastricht University; KU Leuven
RP Vancampfort, D (corresponding author), Katholieke Univ Leuven, Univ Psychiat Ctr, Campus Kortenberg,Leuvensesteenweg 517, B-3070 Kortenberg, Belgium.
EM Davy.Vancampfort@uc-kortenberg.be
RI van Winkel, Ruud/B-9486-2008; Probst, Michel/ABE-6137-2020; Vancampfort,
   Davy/AAD-1987-2019; De Hert, Marc/AAH-6090-2021
OI van Winkel, Ruud/0000-0001-6262-1935; De Hert, Marc/0000-0003-4255-5920
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NR 54
TC 122
Z9 136
U1 0
U2 42
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0165-1781
J9 PSYCHIAT RES
JI Psychiatry Res.
PD MAY 15
PY 2013
VL 207
IS 1-2
BP 25
EP 32
DI 10.1016/j.psychres.2012.09.026
PG 8
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 147RG
UT WOS:000319184100004
PM 23051886
DA 2025-06-11
ER

PT J
AU Hassanizadeh, S
   Shojaei, M
   Bagherniya, M
   Orekhov, AN
   Sahebkar, A
AF Hassanizadeh, Shirin
   Shojaei, Mehrnaz
   Bagherniya, Mohammad
   Orekhov, Alexander N.
   Sahebkar, Amirhossein
TI Effect of nano-curcumin on various diseases: A comprehensive review of
   clinical trials
SO BIOFACTORS
LA English
DT Review
DE cancer; chronic diseases; clinical trial; metabolic syndrome;
   nano-curcumin; neurological disorder; oral disease
ID TYPE-2 DIABETES-MELLITUS; DOUBLE-BLIND; LIPID PROFILE; SERUM-LEVEL;
   SUPPLEMENTATION; NANOCURCUMIN; CELLS; NANOPARTICLES; ENCAPSULATION;
   HEMODIALYSIS
AB The antioxidant, anti-inflammatory, and antibacterial properties of curcumin have made it a valuable herbal product for improving various disorders, such as COVID-19, cancer, depression, anxiety, osteoarthritis, migraine, and diabetes. Recent research has demonstrated that encapsulating curcumin in nanoparticles might improve its therapeutic effects and bioavailability. To our knowledge, the efficacy of nano-curcumin on different aspects of health and disease has not been summarized in a study. Therefore, this review aimed to evaluate nano-curcumin's efficacy in various diseases based on the findings of clinical trials. In order to review publications focusing on nanocurcumin's impact on various diseases, four databases were searched, including PubMed, Scopus, Web of Science, and Google Scholar. This review highlights the potential benefits of nano-curcumin in improving a wide range of human diseases including COVID-19, neurological disorders, chronic disease, oral diseases, osteoarthritis, metabolic syndrome, and other diseases, especially as an adjunct to standard therapy and a healthy lifestyle.
C1 [Hassanizadeh, Shirin; Shojaei, Mehrnaz; Bagherniya, Mohammad] Isfahan Univ Med Sci, Nutr & Food Secur Res Ctr, Esfahan, Iran.
   [Hassanizadeh, Shirin; Shojaei, Mehrnaz; Bagherniya, Mohammad] Isfahan Univ Med Sci, Sch Nutr & Food Sci, Dept Community Nutr, Esfahan, Iran.
   [Bagherniya, Mohammad] Isfahan Univ Med Sci, Anesthesia & Crit Care Res Ctr, Esfahan, Iran.
   [Orekhov, Alexander N.] Inst Gen Pathol & Pathophysiol, Moscow, Russia.
   [Orekhov, Alexander N.] Inst Atherosclerosis Res, Moscow, Russia.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Appl Biomed Res Ctr, Mashhad, Iran.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Biotechnol Res Ctr, Mashhad, Iran.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Sch Pharm, Dept Biotechnol, Mashhad, Iran.
C3 Isfahan University of Medical Sciences; Isfahan University of Medical
   Sciences; Isfahan University of Medical Sciences; Russian Academy of
   Medical Sciences; Institute of General Pathology & Pathophysiology,
   RAMS; Mashhad University of Medical Sciences; Mashhad University of
   Medical Sciences; Mashhad University of Medical Sciences
RP Bagherniya, M (corresponding author), Isfahan Univ Med Sci, Nutr & Food Secur Res Ctr, Esfahan, Iran.; Bagherniya, M (corresponding author), Isfahan Univ Med Sci, Sch Nutr & Food Sci, Dept Community Nutr, Esfahan, Iran.; Sahebkar, A (corresponding author), Mashhad Univ Med Sci, Sch Pharm, Dept Biotechnol, Mashhad, Iran.
EM Bagherniya@nutr.mui.ac.ir; sahebkara@mums.ac.ir
RI Sahebkar, Amirhossein/B-5124-2018; Orekhov, Alexander/J-4838-2013
FU Russian Science Foundation [22-65-00005]
FX Russian Science Foundation, Grant/Award Number: 22-65-00005
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NR 124
TC 37
Z9 37
U1 5
U2 42
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0951-6433
EI 1872-8081
J9 BIOFACTORS
JI Biofactors
PD MAY
PY 2023
VL 49
IS 3
BP 512
EP 533
DI 10.1002/biof.1932
EA JAN 2023
PG 22
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA I4AN4
UT WOS:000908032500001
PM 36607090
DA 2025-06-11
ER

PT J
AU van Haeringen, M
   Milaneschi, Y
   Lamers, F
   Penninx, BWJH
   Jansen, R
AF van Haeringen, Marije
   Milaneschi, Yuri
   Lamers, Femke
   Penninx, Brenda W. J. H.
   Jansen, Rick
TI Dissection of depression heterogeneity using proteomic clusters
SO PSYCHOLOGICAL MEDICINE
LA English
DT Article
DE Depression; heterogeneity; proteomics; WGCNA
ID C-REACTIVE PROTEIN; METABOLIC SYNDROME; ATYPICAL FEATURES; MAJOR
   DEPRESSION; METAANALYSIS; ASSOCIATION; ANXIETY; OBESITY; ABNORMALITIES;
   NETHERLANDS
AB Background The search for relevant biomarkers of major depressive disorder (MDD) is challenged by heterogeneity; biological alterations may vary in patients expressing different symptom profiles. Moreover, most research considers a limited number of biomarkers, which may not be adequate for tagging complex network-level mechanisms. Here we studied clusters of proteins and examined their relation with MDD and individual depressive symptoms. Methods The sample consisted of 1621 subjects from the Netherlands Study of Depression and Anxiety (NESDA). MDD diagnoses were based on DSM-IV criteria and the Inventory of Depressive Symptomatology questionnaire measured endorsement of 30 symptoms. Serum protein levels were detected using a multi-analyte platform (171 analytes, immunoassay, Myriad RBM DiscoveryMAP 250+). Proteomic clusters were computed using weighted correlation network analysis (WGCNA). Results Six proteomic clusters were identified, of which one was nominally significantly associated with current MDD (p = 9.62E-03, Bonferroni adj. p = 0.057). This cluster contained 21 analytes and was enriched with pathways involved in inflammation and metabolism [including C-reactive protein (CRP), leptin and insulin]. At the individual symptom level, this proteomic cluster was associated with ten symptoms, among which were five atypical, energy-related symptoms. After correcting for several health and lifestyle covariates, hypersomnia, increased appetite, panic and weight gain remained significantly associated with the cluster. Conclusions Our findings support the idea that alterations in a network of proteins involved in inflammatory and metabolic processes are present in MDD, but these alterations map predominantly to clinical symptoms reflecting an imbalance between energy intake and expenditure.
C1 [van Haeringen, Marije] Vrije Univ, Amsterdam Publ Hlth Res Inst, Dept Psychiat, Amsterdam UMC, Amsterdam, Netherlands.
   Amsterdam Neurosci, Amsterdam, Netherlands.
C3 University of Amsterdam; Vrije Universiteit Amsterdam; Vrije
   Universiteit Amsterdam
RP van Haeringen, M (corresponding author), Vrije Univ, Amsterdam Publ Hlth Res Inst, Dept Psychiat, Amsterdam UMC, Amsterdam, Netherlands.
EM marijevanhaeringen@gmail.com
RI Lamers, Femke/G-5161-2012; Jansen, Ritsert/C-1160-2013; Penninx,
   Brenda/S-7627-2017
OI van Haeringen, Marije/0000-0001-8793-0195; Milaneschi,
   Yuri/0000-0002-3697-6617
FU ZonMw: The Netherlands Organization for Health Research and Development
   [636310017]; Netherlands Organisation for Health Research and
   Development (ZonMw) [10-000-1002]
FX Funding for this work was provided by ZonMw: The Netherlands
   Organization for Health Research and Development (project number:
   636310017, research program GGZ). The infrastructure for the NESDA study
   (http://www.nesda.nl) is funded through the Geestkracht program of the
   Netherlands Organisation for Health Research and Development (ZonMw,
   grant number 10-000-1002) and financial contributions by participating
   universities and mental health care organizations (VU University Medical
   Center, GGZ inGeest, Leiden University Medical Center, Leiden
   University, GGZ Rivierduinen, University Medical Center Groningen,
   University of Groningen, Lentis, GGZ Friesland, GGZ Drenthe, Rob Giel
   Onderzoekscentrum).
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NR 51
TC 17
Z9 17
U1 0
U2 7
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0033-2917
EI 1469-8978
J9 PSYCHOL MED
JI Psychol. Med.
PD MAY
PY 2023
VL 53
IS 7
BP 2904
EP 2912
AR PII S0033291721004888
DI 10.1017/S0033291721004888
EA JAN 2022
PG 9
WC Psychology, Clinical; Psychiatry; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA I1FE0
UT WOS:000743775500001
PM 35039097
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Moss, K
   Meurk, C
   Steele, ML
   Heffernan, E
AF Moss, Katherine
   Meurk, Carla
   Steele, Megan L.
   Heffernan, Ed
TI Physical Health and Activity of Inpatients under Forensic Mental Health
   Care: A Cross-Sectional Survey and Audit of Patients in a High Secure
   Setting in Queensland, Australia
SO INTERNATIONAL JOURNAL OF FORENSIC MENTAL HEALTH
LA English
DT Article
DE Exercise; physical activity; health; obesity; forensic psychiatry
ID WEIGHT-GAIN; PEOPLE; ILLNESS; SCHIZOPHRENIA; INDIVIDUALS; PREVALENCE;
   EXERCISE; IMPACT; RISK; TOOL
AB Obesity and metabolic syndrome are disproportionately prevalent among people with mental disorders, particularly those subject to long periods of inpatient care where sedentary lifestyle and medication side effects can be compounding problems. This study reports on a cross-sectional survey of 28 patients under forensic mental health care in a high secure inpatient service in Queensland, Australia. The study comprises a file review, structured questionnaire and an interview, to evaluate the physical health and activity, as well as possible causes of low physical activity of these patients. Rates of overweight (50.0%), obesity (46.6%), and metabolic syndrome (39.3%) were very high within the study population. Mean waist circumference measurements were also high for both females (110.8 cm) and males (109.0 cm). Around one half of the study population (46.4%) did not meet the World Health Organization's recommended levels of physical activity. Self-reported low levels of physical activity were significantly associated with the presence of comorbid medical illness (p = 0.007). Further research investigating the factors contributing to poor physical health and low activity levels within this population will support attempts to understand and address the physical health needs of this population.
C1 [Moss, Katherine; Meurk, Carla; Heffernan, Ed] Univ Queensland, Sch Publ Hlth, Herston, Qld, Australia.
   [Moss, Katherine; Meurk, Carla; Steele, Megan L.; Heffernan, Ed] West Moreton Hosp & Hlth Serv, Queensland Ctr Mental Hlth Res, Forens Mental Hlth Grp, Wacol, Qld, Australia.
   [Moss, Katherine; Heffernan, Ed] Metro North Hosp & Hlth Serv, Queensland Hlth, Queensland Forens Mental Hlth Serv, Brisbane, Qld, Australia.
   [Steele, Megan L.] Univ Queensland, Off Med Educ, Herston, Qld, Australia.
   [Moss, Katherine] Queensland Forens Mental Hlth Serv, 270 Roma St, Brisbane, Qld 4000, Australia.
C3 University of Queensland; Queensland Centre for Mental Health Research;
   Queensland Health; University of Queensland
RP Moss, K (corresponding author), Queensland Forens Mental Hlth Serv, 270 Roma St, Brisbane, Qld 4000, Australia.
EM katherine.moss@health.qld.gov.au
RI Heffernan, Edward/K-3687-2014; Steele, Megan/P-3503-2017; Meurk,
   Carla/A-7571-2013
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NR 43
TC 1
Z9 1
U1 1
U2 1
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 1499-9013
EI 1932-9903
J9 INT J FORENSIC MENT
JI Int. J. Forensic Ment. Health
PD JAN 2
PY 2024
VL 23
IS 1
BP 12
EP 23
DI 10.1080/14999013.2022.2154872
EA DEC 2022
PG 12
WC Criminology & Penology; Psychiatry
WE Social Science Citation Index (SSCI)
SC Criminology & Penology; Psychiatry
GA GK8P4
UT WOS:000897098800001
DA 2025-06-11
ER

PT J
AU Naz, MSG
   Rahnemaei, FA
   Tehrani, FR
   Sayehmiri, F
   Ghasemi, V
   Banaei, M
   Ozgoli, G
AF Naz, Marzieh Saei Ghare
   Rahnemaei, Fatemeh Alsadat
   Tehrani, Fahimeh Ramezani
   Sayehmiri, Fatemeh
   Ghasemi, Vida
   Banaei, Mojdeh
   Ozgoli, Giti
TI Possible cognition changes in women with polycystic ovary syndrome: a
   narrative review
SO OBSTETRICS & GYNECOLOGY SCIENCE
LA English
DT Review
DE Polycystic ovary syndrome; Cognitive function; Metabolic syndrome;
   Review
ID QUALITY-OF-LIFE; METABOLIC SYNDROME; ORAL-CONTRACEPTIVES; SPATIAL
   COGNITION; ECONOMIC BURDEN; RISK-FACTORS; PREVALENCE; DEPRESSION;
   ANXIETY; IMPACT
AB Nowadays, polycystic ovary syndrome (PCOS) and cognitive dysfunction are major health problems among female. This narrative review aimed to investigate cognitive dysfunction in female with PCOS. English and Persian articles published in PubMed, Scopus, Web of Science, Google Scholar, PsycINFO, Scientific Information Database, and Cochrane Database of Systematic Reviews until May 2022 were searched. Sixteen studies involving 850 female with PCOS and 974 controls were assessed. In these studies, the association between biochemical factors and symptoms of PCOS and memory, attention, executive functioning, information processing speed, and visuospatial skills was evaluated. The literature review revealed the possible cognitive changes in female with PCOS. This study summarized the different aspects of cognitive function in female with PCOS due to medication, psychological problems (mood disorders caused by disease symptoms and complications), and biochemical markers, such as metabolic and sex hormone abnormalities. Considering the existing scientific gap regarding the possibility of cognitive complications in female with PCOS, further biological studies should be conducted to evaluate the potential mechanisms involved.
C1 [Naz, Marzieh Saei Ghare; Tehrani, Fahimeh Ramezani] Shahid Beheshti Univ Med Sci, Res Inst Endocrine Sci, Reprod Endocrinol Res Ctr, Tehran, Iran.
   [Rahnemaei, Fatemeh Alsadat] Guilan Univ Med Sci, Sch Med, Al Zahra Hosp, Dept Obstet Gynecol,Reprod Hlth Res Ctr,Dept Obst, Rasht, Iran.
   [Sayehmiri, Fatemeh] Shahid Beheshti Univ Med Sci, Loghman Hakim Hosp, Skull Base Res Ctr, Tehran, Iran.
   [Ghasemi, Vida] Asadabad Sch Med Sci, Dept Nursing, Asadabad, Iran.
   [Banaei, Mojdeh] Hormozgan Univ Med Sci, Mother & Child Welf Res Ctr, Bandar Abbas, Iran.
   [Ozgoli, Giti] Shahid Beheshti Univ Med Sci, Sch Nursing & Midwifery, Dept Midwifery & Reprod Hlth, Midwifery & Reprod Hlth Res Ctr, Tehran 1996835119, Iran.
C3 Shahid Beheshti University Medical Sciences; Guilan University of
   Medical Sciences; Shahid Beheshti University Medical Sciences; Shahid
   Beheshti University Medical Sciences
RP Ozgoli, G (corresponding author), Shahid Beheshti Univ Med Sci, Sch Nursing & Midwifery, Dept Midwifery & Reprod Hlth, Midwifery & Reprod Hlth Res Ctr, Tehran 1996835119, Iran.
EM gozgoli@gmail.com
RI Tehrani, Fahimeh/H-6133-2017; Naz, Marzieh/K-8811-2019; ghasemi,
   vida/K-5490-2018
OI rahnemaei, fatemeh alsadat/0000-0002-1149-8057; Saei Ghare Naz,
   Marzieh/0000-0002-1259-2459
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NR 118
TC 5
Z9 5
U1 1
U2 3
PU Korean Soc Obstetrics and Gynecology (KSOG)
PI Seoul
PA 4th Floor, 36 Gangnam-daero 132-gil, Gangnam-gu, Seoul, SOUTH KOREA
SN 2287-8572
EI 2287-8580
J9 OBSTET GYNECOL SCI
JI Obstet. Gynecol. Sci.
PD SEP
PY 2023
VL 66
IS 5
BP 347
EP 363
DI 10.5468/ogs.22165
PG 17
WC Obstetrics & Gynecology
WE Emerging Sources Citation Index (ESCI)
SC Obstetrics & Gynecology
GA S8JG8
UT WOS:001073569900002
PM 37376796
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Ma, WF
   Wu, PL
   Su, CH
   Yang, TC
AF Ma, Wei-Fen
   Wu, Po-Lun
   Su, Chia-Hsien
   Yang, Tzu-Ching
TI The Effects of an Exercise Program on Anxiety Levels and Metabolic
   Functions in Patients With Anxiety Disorders
SO BIOLOGICAL RESEARCH FOR NURSING
LA English
DT Article
DE anxiety; community; exercise program; mental illness; metabolic control
   function
ID PHYSICAL-ACTIVITY; TAIWANESE ADULTS; BLOOD-PRESSURE; DEPRESSION; LIFE;
   METAANALYSIS; COMORBIDITY; GLUCOSE; IMPACT
AB The purpose of this study was to evaluate the effects of a home-based (HB) exercise program on anxiety levels and metabolic functions in patients with anxiety disorders in Taiwan. Purposive sampling was used to recruit 86 participants for this randomized, experimental study. Participants were asked to complete a pretest before the 3-month exercise program, a posttest at 1 week, and a follow-up test at 3 months after the exercise program. Study measures included four Self-Report Scales and biophysical assessments to collect and assess personal data, lifestyle behaviors, anxiety levels, and metabolic control functions. Of the 86 study participants, 83 completed the posttest and the 3-month follow-up test, including 41 in the experimental group and 42 in the control group. Participants in the experimental group showed significant improvements in body mass index, high-density lipoprotein cholesterol levels, and the level of moderate exercise after the program relative to the control group, as analyzed by generalized estimating equations mixed-model repeated measures. State and trait anxiety levels were also significantly improved from pretest to follow-up test in the experimental group. Finally, the prevalence of metabolic syndrome declined for participants in the experimental group. The HB exercise program produced positive effects on the metabolic indicators and anxiety levels of Taiwanese adults with anxiety disorders. Health providers should consider using similar HB exercise programs to help improve the mental and physical health of patients with anxiety disorders in their communities.
C1 [Ma, Wei-Fen; Yang, Tzu-Ching] China Med Univ, Sch Nursing, 91 Hsueh Shih Rd, Taichung 40402, Taiwan.
   [Ma, Wei-Fen; Su, Chia-Hsien] China Med Univ Hosp, Dept Nursing, Taichung, Taiwan.
   [Wu, Po-Lun] China Med Univ Hosp, Dept Psychiat, Taichung, Taiwan.
   [Su, Chia-Hsien; Yang, Tzu-Ching] China Med Univ, Dept Publ Hlth Nursing, Taichung, Taiwan.
C3 China Medical University Taiwan; China Medical University Taiwan; China
   Medical University Hospital - Taiwan; China Medical University Taiwan;
   China Medical University Hospital - Taiwan; China Medical University
   Taiwan
RP Ma, WF (corresponding author), China Med Univ, Sch Nursing, 91 Hsueh Shih Rd, Taichung 40402, Taiwan.
EM lhdaisy@mail.cmu.edu.tw
RI Ma, Wei-Fen/D-2087-2012
FU National Science Council, Taiwan [NSC101-2511-S-039-003,
   NSC102-2314-B-039-010-MY3]
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: The study
   was supported by research grants from the National Science Council
   (NSC101-2511-S-039-003; NSC102-2314-B-039-010-MY3), Taiwan.
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NR 55
TC 12
Z9 12
U1 0
U2 19
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1099-8004
EI 1552-4175
J9 BIOL RES NURS
JI Biol. Res. Nurs.
PD MAY
PY 2017
VL 19
IS 3
BP 258
EP 268
DI 10.1177/1099800416672581
PG 11
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA ET2BB
UT WOS:000400072200002
PM 27729394
DA 2025-06-11
ER

PT J
AU Morell, R
   Curtis, J
   Watkins, A
   Poole, J
   Fibbins, H
   Rossimel, E
   Gerrard, M
   White, A
   Teasdale, S
   Ward, PB
   Lappin, J
AF Morell, Rachel
   Curtis, Jackie
   Watkins, Andrew
   Poole, Josephine
   Fibbins, Hamish
   Rossimel, Elisa
   Gerrard, Mark
   White, Annette
   Teasdale, Scott
   Ward, Philip B.
   Lappin, Julia
TI Cardio-metabolic risk in individuals prescribed long-acting injectable
   antipsychotic medication
SO PSYCHIATRY RESEARCH
LA English
DT Article
DE Severe mental illness; Physical health; Metabolic syndrome
ID AUSTRALIAN NATIONAL-SURVEY; CARDIOVASCULAR-DISEASE; PSYCHOTIC DISORDERS;
   PHYSICAL ILLNESS; ASSESSMENT-TOOL; MENTAL-ILLNESS; SCHIZOPHRENIA;
   PEOPLE; METAANALYSIS; CARE
AB People living with severe mental illness (SMI) experience significant physical health co-morbidity. Few studies have focused on physical health outcomes for those prescribed long-acting injectable (LAI) antipsychotics. This observational cross-sectional study aimed to assess the prevalence of metabolic syndrome (MetS) and other cardio-metabolic risk factors in a large cohort prescribed LAI and managed by community mental health services. For participants with elevated cardio-metabolic risk factors, the proportion receiving appropriate management was assessed. Of the 301 eligible participants, many met the full criteria for MetS (44%) and its components. Cardio-metabolic risk factors were largely under- or un-treated. Smoking rates were very high (62%) along with reported high rates of physical inactivity and poor dietary intake. The vast majority (89%) reported seeing their general practitioner in the preceding twelve months. Individuals prescribed LAI have a very high prevalence of MetS and potentially modifiable risk factors for cardiovascular disease. Routine monitoring accompanied by evidence-based treatment of cardiometabolic abnormalities which contribute to significant morbidity, disability and premature death should be prioritised. Better collaboration between mental health services and primary care providers should be pursued to optimise the delivery of effective physical health care to individuals living with SMI.
C1 [Morell, Rachel; Curtis, Jackie; Watkins, Andrew; Poole, Josephine; Fibbins, Hamish; Rossimel, Elisa; Gerrard, Mark; White, Annette; Teasdale, Scott; Lappin, Julia] South Eastern Sydney Local Hlth Dist, Keeping Body Mind, Bondi Jct, NSW, Australia.
   [Morell, Rachel; Curtis, Jackie; Fibbins, Hamish; Teasdale, Scott; Ward, Philip B.; Lappin, Julia] UNSW Sydney, Sch Psychiat, Kensington, NSW, Australia.
   [Ward, Philip B.] Ingham Inst Appl Med Res, Schizophrenia Res Unit, Liverpool, NSW, Australia.
C3 University of New South Wales Sydney; Ingham Institute for Applied
   Medical Research
RP Morell, R (corresponding author), 26 Llandaff St, Bondi Jct, NSW 2022, Australia.
EM r.morell@unsw.edu.au
RI Curtis, Jackie/J-5789-2019; Lappin, Julia/AAA-6596-2020; Teasdale,
   Scott/AFP-0676-2022; Fibbins, Hamish/KLZ-4932-2024; Ward,
   Philip/JCE-6293-2023
OI Fibbins, Hamish/0000-0002-2673-7866; Watkins,
   Andrew/0000-0003-3452-8682; Teasdale, Scott/0000-0001-6769-8421; Lappin,
   Julia/0000-0001-5946-2144; Curtis, Jackie/0000-0001-6884-0098; Ward,
   Philip/0000-0002-5779-7722; Morell, Rachel/0000-0003-3065-5318
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NR 53
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Z9 20
U1 2
U2 9
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0165-1781
J9 PSYCHIAT RES
JI Psychiatry Res.
PD NOV
PY 2019
VL 281
AR 112606
DI 10.1016/j.psychres.2019.112606
PG 7
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA JO0BH
UT WOS:000497252200044
PM 31629301
DA 2025-06-11
ER

PT J
AU Silic, A
   Vukojevic, J
   Peitl, V
   De Hert, M
   Karlovic, D
AF Silic, Ante
   Vukojevic, Jaksa
   Peitl, Vjekoslav
   De Hert, Marc
   Karlovic, Dalibor
TI Major depressive disorder: a possible typisation according to serotonin,
   inflammation, and metabolic syndrome
SO ACTA NEUROPSYCHIATRICA
LA English
DT Article
DE MDD; depression; metabolic syndrome; serotonin; inflammation
ID METAANALYSIS; ASSOCIATION; PREVALENCE; CYTOKINES; RESPONSES; SYMPTOMS;
   DISEASE
AB Objective:Major depressive disorder (MDD) is closely related to obesity, inflammation, and insulin resistance, all together being etiologically linked to metabolic syndrome (MetS) development. The depressive disorder has a neuroendocrinological component, co-influencing the MetS, while MetS is characterised by increased cytokine levels, which are known to cause a depressed mood. This study aimed to establish biological subtypes of the depressive disorder based on researched clinical, laboratory, and anthropometric variables. Methods:We performed a cross-sectional study on a sample of 293 subjects (145 suffering from a depressive disorder and 148 healthy controls). Results were analysed with multivariate statistical methods as well as with cluster and discriminant analysis. In order to classify depressive disorder on the grounds of laboratory, anthropometric, and clinical parameters, we performed cluster analysis, which resulted in three clusters. Results:The first cluster is characterised by low platelet serotonin, high cortisol levels, high blood glucose levels, high triglycerides levels, high Hamilton Depression Rating Scale score, high waist circumference, high C-Reactive Protein values, and a high number of previous depressive episodes, was named Combined (Metabolic) depression. The inflammatory depression cluster is defined with average platelet serotonin values, normal cortisol, and all other parameter levels, except for increased IL-6 levels. The serotoninergic depression cluster is characterised by markedly low platelet serotonin, and all other parameters are within the normal range. Conclusions:From a biological point of view, depressive disorder is not uniform, and as such, these findings suggest potential clinically useful and generalisable biological subtypes of depressive disorder.
C1 [Silic, Ante; Peitl, Vjekoslav; Karlovic, Dalibor] Univ Hosp Ctr Sestre Milosrdnice, Dept Psychiat, Zagreb, Croatia.
   [Silic, Ante; Peitl, Vjekoslav; Karlovic, Dalibor] Catholic Univ Croatia, Sch Med, Zagreb, Croatia.
   [Vukojevic, Jaksa] Univ Zagreb, Dept pharmacol, Zagreb, Croatia.
   [De Hert, Marc] Katholieke Univ Leuven, Univ Psychiat Ctr, Leuven, Belgium.
   [De Hert, Marc] Katholieke Univ Leuven, Dept Neurosci, Clin Psychiat, Leuven, Belgium.
   [De Hert, Marc] Antwerp Univ, AHLEC, Antwerp, Belgium.
C3 University of Zagreb; KU Leuven; KU Leuven; University of Antwerp
RP Peitl, V (corresponding author), Univ Hosp Ctr Sestre Milosrdnice, Dept Psychiat, Zagreb, Croatia.; Peitl, V (corresponding author), Catholic Univ Croatia, Sch Med, Zagreb, Croatia.
EM vjekoslav.peitl@gmail.com
RI De Hert, Marc/AAH-6090-2021; Peitl, Vjekoslav/Q-9358-2018
OI Peitl, Vjekoslav/0000-0003-4163-6411; Vukojevic,
   Jaksa/0000-0003-4215-6743; De Hert, Marc/0000-0003-4255-5920
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NR 47
TC 6
Z9 7
U1 2
U2 7
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
SN 1601-5215
J9 ACTA NEUROPSYCHIATR
JI Acta Neuropsychiatr.
PD FEB
PY 2022
VL 34
IS 1
BP 15
EP 23
AR PII S0924270821000302
DI 10.1017/neu.2021.30
PG 9
WC Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Psychiatry
GA 6O8RF
UT WOS:000890505600003
PM 34503595
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Horne, R
   Foster, JA
AF Horne, Rachael
   Foster, Jane A.
TI Metabolic and Microbiota Measures as Peripheral Biomarkers in Major
   Depressive Disorder
SO FRONTIERS IN PSYCHIATRY
LA English
DT Review
DE gut-brain axis; microbiome; leptin; ghrelin; major depression (MDD)
ID RECEPTOR MESSENGER-RNA; GUT MICROBIOTA; LEPTIN LEVELS; FECAL MICROBIOTA;
   LIPID-METABOLISM; GHRELIN LEVELS; SERUM GHRELIN; FOOD-INTAKE; BRAIN;
   STRESS
AB Advances in understanding the role of the microbiome in physical and mental health are at the forefront of medical research and hold potential to have a direct impact on precision medicine approaches. In the past 7 years, we have studied the role of microbiota-brain communication on behavior in mouse models using germ-free mice, mice exposed to antibiotics, and healthy specific pathogen free mice. Through our work and that of others, we have seen an amazing increase in our knowledge of how bacteria signal to the brain and the implications this has for psychiatry. Gut microbiota composition and function are influenced both by genetics, age, sex, diet, life experiences, and many other factors of psychiatric and bodily disorders and thus may act as potential biomarkers of the gut-brain axis that could be used in psychiatry and co-morbid conditions. There is a particular need in major depressive disorder and other mental illness to identify biomarkers that can stratify patients into more homogeneous groups to provide better treatment and for development of new therapeutic approaches. Peripheral outcome measures of host-microbe bidirectional communication have significant translational value as biomarkers. Enabling stratification of clinical populations, based on individual biological differences, to predict treatment response to pharmacological and non-pharmacological interventions. Here we consider the links between co-morbid metabolic syndrome and depression, focusing on biomarkers including leptin and ghrelin in combination with assessing gut microbiota composition, as a potential tool to help identify individual differences in depressed population.
C1 [Horne, Rachael; Foster, Jane A.] McMaster Univ, Dept Psychiat & Behav Neurosci, Hamilton, ON, Canada.
   [Foster, Jane A.] St Michaels Hosp, Dept Psychiat, Toronto, ON, Canada.
C3 McMaster University; University of Toronto; Saint Michaels Hospital
   Toronto
RP Foster, JA (corresponding author), McMaster Univ, Dept Psychiat & Behav Neurosci, Hamilton, ON, Canada.; Foster, JA (corresponding author), St Michaels Hosp, Dept Psychiat, Toronto, ON, Canada.
EM jfoster@mcmaster.ca
RI Foster, Jane/AAW-7163-2021
OI Foster, Jane/0000-0002-8579-4705
FU Ontario Brain Institute - Ontario Government; Canadian Institutes of
   Health Research (CIHR)
FX This research was conducted as part of the Canadian Biomarker
   Integration Network in Depression (CAN-BIND), an Integrated Discovery
   Program supported by the Ontario Brain Institute, which is an
   independent non-profit corporation, funded partially by the Ontario
   Government. The opinions, results and conclusions are those of the
   authors and no endorsement by the Ontario Brain Institute is intended or
   should be inferred. Graduate stipend funding was provided by the
   Canadian Institutes of Health Research (CIHR).
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NR 96
TC 30
Z9 32
U1 1
U2 40
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-0640
J9 FRONT PSYCHIATRY
JI Front. Psychiatry
PD OCT 22
PY 2018
VL 9
AR 513
DI 10.3389/fpsyt.2018.00513
PG 8
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA GX5YZ
UT WOS:000447833500001
PM 30405455
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Guardiola, M
   Muntané, G
   Martínez, I
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   Ibarretxe, D
   Plana, N
   Bullido, MJ
   Vilella, E
   Ribalta, J
AF Guardiola, Montse
   Muntane, Gerard
   Martinez, Iris
   Martorell, Lourdes
   Girona, Josefa
   Ibarretxe, Daiana
   Plana, Nuria
   Bullido, Maria J.
   Vilella, Elisabet
   Ribalta, Josep
TI Metabolic Overlap between Alzheimer's Disease and Metabolic Syndrome
   Identifies the PVRL2 Gene as a New Modulator of Diabetic
   Dyslipidemia
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE Alzheimer's disease; diabetes; lipid; PVRL2
ID LOW-DENSITY-LIPOPROTEIN; OXIDATIVE STRESS; RISK-FACTOR; POLYMORPHISM;
   CHOLESTEROL; ASSOCIATION; ATHEROSCLEROSIS; MECHANISMS; DEMENTIA;
   IMPAIRMENT
AB Background: Alzheimer's disease (AD) and type 2 diabetes mellitus (T2DM) share metabolic alterations such as abnormal insulin and lipid metabolism and have some common genetic factors such as APOE genotype. Taking this into account, we hypothesized that we could identify common genetic factors involved in the development of diabetes and cardiovascular diseases. Methodology: We first genotyped 48 single nucleotide polymorphisms (SNPs) previously associated with AD in a cohort composed of 330 patients with cognitive impairment (CI) to assess their association with plasma lipids. Second, we conducted pleiotropy-informed conjunctional false discovery rate (FDR) analysis designed to identify shared variants between AD and plasma lipid levels. Finally, we used the SNPs to be found associated with lipid parameters and AD to search for associations with lipoprotein parameters in 281 patients with cardiometabolic risk. Results: Five SNPs were significantly associated with lower levels of cholesterol transported in remnant lipoprotein particles (RLPc) in subjects with CI; among these SNPs was the rs73572039 variant in PVRL2. Stratified QQ-plots were conducted on GWAS designed for AD and triglycerides (TG). The cross-trait analysis resulted in a total of 22 independent genomic loci associated with both AD and TG levels with a conjFDR < 0.05. Among these loci, two pleiotropic variants were located in PVRL2 (rs12978931 and rs11667640). The three SNPs in PVRL2 were significantly associated with RLPc, TG, and number of circulating VLDL and HDL particles in subjects with cardiometabolic risk. Conclusions: We have identified three variants in PVRL2 that predispose individuals to AD that also influence the lipid profile that confers cardiovascular risk in T2DM subjects. PVRL2 is a potential new modulating factor of atherogenic dyslipidemia.
C1 [Guardiola, Montse; Martinez, Iris; Girona, Josefa; Ibarretxe, Daiana; Plana, Nuria; Ribalta, Josep] Univ Rovira i Virgili, Dept Med & Cirurgia, Unitat Recerca Lipids & Arteriosclerosi, Reus 43201, Spain.
   [Guardiola, Montse; Muntane, Gerard; Martorell, Lourdes; Girona, Josefa; Ibarretxe, Daiana; Plana, Nuria; Vilella, Elisabet; Ribalta, Josep] Inst Invest Sanitaria Pere Virgili CERCA, Reus 43204, Spain.
   [Guardiola, Montse; Girona, Josefa; Ibarretxe, Daiana; Plana, Nuria; Ribalta, Josep] Inst Salud Carlos III, CIBERDEM, Ctr Invest Biomed Red Diabet & Enfermedades Metab, Madrid 28029, Spain.
   [Muntane, Gerard; Martorell, Lourdes; Vilella, Elisabet] Hosp Univ Inst Pere Mata, Reus 43206, Spain.
   [Muntane, Gerard; Martorell, Lourdes; Vilella, Elisabet] Univ Rovira i Virgili, Dept Med & Cirurgia, Genet & Ambient Psiquiatria, Reus 43201, Spain.
   [Muntane, Gerard; Martorell, Lourdes; Vilella, Elisabet] Inst Salud Carlos III, CIBERSAM, Ctr Invest Biomed Red Salud Mental, Madrid 28029, Spain.
   [Ibarretxe, Daiana; Plana, Nuria] Hosp Univ St Joan de Reus, Unitat Med Vasc & Metab, Serv Med Interna, Reus 43204, Spain.
   [Bullido, Maria J.] Univ Autonoma Madrid, Ctr Biol Mol Severo Ochoa CSIC UAM, Madrid 28049, Spain.
   [Bullido, Maria J.] Carlos III Inst Hlth, Ctr Networked Biomed Res Neurodegenerat Dis, CIBERNED, Madrid 28029, Spain.
   [Bullido, Maria J.] Univ Autonoma Madrid, Hosp Univ La Paz, Inst Invest Sanitaria Hosp Univ La Paz, IdiPAZ, Madrid 28029, Spain.
C3 Universitat Rovira i Virgili; Instituto de Salud Carlos III; CIBER -
   Centro de Investigacion Biomedica en Red; CIBERDEM; Universitat Rovira i
   Virgili; Instituto de Salud Carlos III; CIBER - Centro de Investigacion
   Biomedica en Red; CIBERSAM; Consejo Superior de Investigaciones
   Cientificas (CSIC); CSIC - Centro de Biologia Molecular Severo Ochoa
   (CBM); Autonomous University of Madrid; CIBERNED; Instituto de Salud
   Carlos III; Hospital Universitario La Paz; Autonomous University of
   Madrid
RP Ribalta, J (corresponding author), Univ Rovira i Virgili, Dept Med & Cirurgia, Unitat Recerca Lipids & Arteriosclerosi, Reus 43201, Spain.; Vilella, E; Ribalta, J (corresponding author), Inst Invest Sanitaria Pere Virgili CERCA, Reus 43204, Spain.; Ribalta, J (corresponding author), Inst Salud Carlos III, CIBERDEM, Ctr Invest Biomed Red Diabet & Enfermedades Metab, Madrid 28029, Spain.; Vilella, E (corresponding author), Hosp Univ Inst Pere Mata, Reus 43206, Spain.; Vilella, E (corresponding author), Univ Rovira i Virgili, Dept Med & Cirurgia, Genet & Ambient Psiquiatria, Reus 43201, Spain.; Vilella, E (corresponding author), Inst Salud Carlos III, CIBERSAM, Ctr Invest Biomed Red Salud Mental, Madrid 28029, Spain.
EM vilellae@peremata.com; josep.ribalta@urv.cat
RI Vilella, Elisabet/HII-9781-2022; Iris E. Martínez-Juárez,
   MSc/AAZ-9428-2020; Muntane, Gerard/V-4477-2019; , Montse/HJY-5534-2023;
   Bullido Gomez-Heras, Maria Jesus/C-8509-2014; Girona, Josefa/U-3489-2018
OI Martorell, Lourdes/0000-0003-4999-2197; Bullido Gomez-Heras, Maria
   Jesus/0000-0002-6477-1117; Guardiola, Montse/0000-0002-9696-7384;
   Ibarretxe, Daiana/0000-0002-5442-1930; Muntane,
   Gerard/0000-0003-1541-8365; Girona, Josefa/0000-0002-6267-8779
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NR 57
TC 5
Z9 5
U1 0
U2 1
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD APR
PY 2023
VL 24
IS 8
AR 7415
DI 10.3390/ijms24087415
PG 15
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA E8GB2
UT WOS:000977851100001
PM 37108578
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Tsakona, P
   Kitsatis, I
   Apostolou, T
   Papadopoulou, O
   Hristara-Papadopoulou, A
AF Tsakona, Pelagia
   Kitsatis, Ioannis
   Apostolou, Thomas
   Papadopoulou, Ourania
   Hristara-Papadopoulou, Alexandra
TI The Effect of Diaphragmatic Breathing as a Complementary Therapeutic
   Strategy in Stress of Children and Teenagers 6-18 Years Old
SO CHILDREN-BASEL
LA English
DT Review
DE effect; diaphragmatic breathing; stress; children; adolescents
ID EARLY-LIFE STRESS; METABOLIC SYNDROME; PULMONARY-FUNCTION; ANXIETY
   DISORDERS; BLOOD-PRESSURE; HEALTH; ADOLESCENTS; EXERCISE; OBESITY;
   PREVALENCE
AB Background: Few studies are reported on interventions that have been carried out in children and adolescents using diaphragmatic breathing (DB) together with methods like counseling, muscle relaxation, therapeutic exercise, and music therapy. Objective: The goal of the review is to evaluate the effectiveness of DB as complementary therapy in the stress of the pediatric population (6-18 years old). Methods: Detailed research was carried out in the current literature to find relevant studies published from 2010 to October 2024 in PubMed and Cochrane Library. Thirteen studies that fulfilled the inclusion criteria were included in the study. Nine studies involved obese and overweight pediatric populations and the other four involved pediatric patients. Results: The interventions comprised two 8-week studies in an obese pediatric population, seven studies in healthy children and adolescents with normal weight. The studies were based on DB, muscle relaxation, nutrition, counseling, music therapy, and slow breathing exercises. The participants in the intervention group improved in comparison to those in the control group in terms of stress and depression in most included studies, in terms of school performance in two studies, in terms of better family relationships in one study, and showed improvement in anthropometric indicators in two studies. In four studies that involved pediatric patients, stress and fear of medical procedures were reduced. Conclusions: DB can effectively contribute on its own or in combination with other therapeutic methods to improving physiological and psychological indicators in the pediatric population. It is useful to integrate stress management programs that include DB training as clinical practice in primary healthcare and in school schedules for elementary and high-school students.
C1 [Tsakona, Pelagia; Apostolou, Thomas; Papadopoulou, Ourania; Hristara-Papadopoulou, Alexandra] Int Hellen Univ, Dept Physiotherapy, Thessaloniki 57400, Greece.
   [Kitsatis, Ioannis] Aristotle Univ Thessaloniki, Sch Med, Thessaloniki 54124, Greece.
C3 International Hellenic University; Aristotle University of Thessaloniki
RP Tsakona, P (corresponding author), Int Hellen Univ, Dept Physiotherapy, Thessaloniki 57400, Greece.
EM ptsakona@yahoo.gr; ikitsatis@auth.gr; apostolouthomas@ihu.gr;
   raniapapadopoulouph2@gmail.com; alekpap@phys.teithe.gr
OI Tsakona, Pelagia/0000-0002-1585-7053; Kitsatis,
   Ioannis/0000-0002-7758-5487
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NR 109
TC 0
Z9 0
U1 7
U2 7
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2227-9067
J9 CHILDREN-BASEL
JI Children-Basel
PD JAN
PY 2025
VL 12
IS 1
AR 59
DI 10.3390/children12010059
PG 21
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA T2Z1V
UT WOS:001403744400001
PM 39857890
OA gold
DA 2025-06-11
ER

PT J
AU Yanes, LL
   Reckelhoff, JF
AF Yanes, Licy L.
   Reckelhoff, Jane F.
TI Postmenopausal Hypertension
SO AMERICAN JOURNAL OF HYPERTENSION
LA English
DT Article
DE 20-HETE; androgens; angiotensinogen; blood pressure; endothelin;
   estrogens; hypertension; leptin; sympathetic activity
ID AMBULATORY BLOOD-PRESSURE; NECROSIS-FACTOR-ALPHA; CARDIOVASCULAR-DISEASE
   RISK; ANGIOTENSIN-II HYPERTENSION; HORMONE REPLACEMENT THERAPY;
   POLYCYSTIC-OVARY-SYNDROME; MESSENGER-RNA EXPRESSION; NF-KAPPA-B;
   ENDOTHELIAL DYSFUNCTION; METABOLIC SYNDROME
AB Cardiovascular disease is the leading cause of morbidity and mortality in postmenopausal women. Hypertension is a major risk factor for cardiovascular disease. The mechanisms responsible for postmenopausal hypertension have not been completely elucidated. However, various mechanisms have been implicated to play a role. For example, there is evidence that changes in estrogen/androgen ratios favoring increases in androgens, activation of the renin-angiotensin and endothelin systems, activation of the sympathetic nervous system, metabolic syndrome and obesity, inflammation, increased vasoconstrictor eicosanoids, and anxiety and depression may be important in the pathogenesis of postmenopausal hypertension. There is also evidence that hypertension is less well controlled in aging women than in aging men, but the reasons for this gender difference is not clear. Postmenopausal hypertension is likely multifactorial. Future studies will be necessary to determine the contribution of these systems listed above in mediating postmenopausal hypertension and to design treatment strategies that encompass these mechanisms to improve the quality of life of postmenopausal women as they age.
C1 [Yanes, Licy L.; Reckelhoff, Jane F.] Univ Mississippi, Med Ctr, Womens Hlth Res Ctr, Jackson, MS 39216 USA.
   [Yanes, Licy L.; Reckelhoff, Jane F.] Univ Mississippi, Med Ctr, Ctr Excellence Cardiovasc Renal Res, Jackson, MS 39216 USA.
   [Yanes, Licy L.; Reckelhoff, Jane F.] Univ Mississippi, Med Ctr, Dept Physiol, Jackson, MS 39216 USA.
   [Yanes, Licy L.; Reckelhoff, Jane F.] Univ Mississippi, Med Ctr, Dept Med, Jackson, MS 39216 USA.
C3 University of Mississippi; University of Mississippi Medical Center;
   University of Mississippi; University of Mississippi Medical Center;
   University of Mississippi Medical Center; University of Mississippi;
   University of Mississippi; University of Mississippi Medical Center
RP Reckelhoff, JF (corresponding author), Univ Mississippi, Med Ctr, Womens Hlth Res Ctr, Jackson, MS 39216 USA.
EM JReckelhoff@umc.edu
FU National Institutes of Health [RO1s HL66072, HL69194, PO1 HL51971];
   American Heart Association [0830239N]; American Heart Association (AHA)
   [0830239N] Funding Source: American Heart Association (AHA)
FX The authors acknowledge the support of the National Institutes of Health
   RO1s HL66072 and HL69194 and PO1 HL51971 (>$10,000 to J.F.R.), and the
   American Heart Association Scientific Development grant #0830239N
   (>$10,000 to L.L.Y.).
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NR 126
TC 144
Z9 159
U1 1
U2 10
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0895-7061
EI 1941-7225
J9 AM J HYPERTENS
JI Am. J. Hypertens.
PD JUL
PY 2011
VL 24
IS 7
BP 740
EP 749
DI 10.1038/ajh.2011.71
PG 10
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 780ZT
UT WOS:000291901100005
PM 21509049
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Capponi, V
   Carrasco, C
   Macchiavello, S
   Undurraga, J
   Campino, C
   Carvajal, C
   Gomez, T
   Weiss, C
   Aedo, I
   Vecchiola, A
   Allende, F
   Solari, S
   Fardella, C
   Baudrand, R
AF Capponi, Valentina
   Carrasco, Carmen
   Macchiavello, Stefano
   Undurraga, Juan
   Campino, Carmen
   Carvajal, Cristian
   Gomez, Teresita
   Weiss, Cristian
   Aedo, Igor
   Vecchiola, Andrea
   Allende, Fidel
   Solari, Sandra
   Fardella, Carlos
   Baudrand, Rene
TI Depressive symptoms are associated with higher morning plasma cortisol
   in primary care subjects
SO NEUROENDOCRINOLOGY LETTERS
LA English
DT Article
DE depression; mood disorder; pituitary adrenal system; cortisol; metabolic
   syndrome
ID DEXAMETHASONE-SUPPRESSION TEST; LC-MS/MS METHOD; PSYCHIATRIC-DISORDERS;
   PSYCHOTIC DEPRESSION; CUSHINGS-SYNDROME; METABOLITES; DST; RISK
AB BACKGROUND: Cortisol dysregulation has a potential role in depression.
   AIM AND METHODS: We evaluated depressive symptoms using the Hamilton Rating Scale for Depression in 48 primary care subjects without history of previous or current depression and its association with cortisol dysregulation (morning plasma cortisol, 24-hour urinary free cortisol and cortisol metabolites). Presence of metabolic syndrome and inflammatory parameters were also assessed.
   RESULTS: Hamilton Rating Scale for Depression correlated significantly with morning cortisol, but not with urinary free cortisol or metabolites. A significant increase in morning cortisol by Hamilton groups (asymptomatic <= 8; mild to moderate: 9-18; moderate to severe: >= 19) was observed even when adjusted by age/gender. We observed no association of depressive symptoms with metabolic or inflammatory parameters.
   CONCLUSIONS: Depressive symptoms in primary care subjects not consulting for their mood are associated with higher morning plasma cortisol, but not urinary cortisol or its metabolites. These observations suggest that systemic hypercortisolism and related metabolic disorders are not observed in mild/initial states of depressive disorders.
C1 [Capponi, Valentina] Univ Chile, Fac Med, Univ Psychiat Clin, Santiago, Chile.
   [Carrasco, Carmen] Univ Desarrollo Clin Alemana, Santiago, Chile.
   [Macchiavello, Stefano; Campino, Carmen; Carvajal, Cristian; Gomez, Teresita; Vecchiola, Andrea; Fardella, Carlos; Baudrand, Rene] Pontificia Univ Catolica Chile, Sch Med, Endocrinol Dept, Santiago, Chile.
   [Undurraga, Juan] Clin Alemana Univ Desarrollo, Fac Med, Dept Psychiat, Santiago, Chile.
   [Undurraga, Juan] J Horwitz Psychiat Inst, Early Intervent Program, Santiago, Chile.
   [Weiss, Cristian; Aedo, Igor] Pontificia Univ Catolica Chile, Sch Med, Psychiat Dept, Santiago, Chile.
   [Allende, Fidel; Solari, Sandra] Pontificia Univ Catolica Chile, Sch Med, Clin Lab Dept, Santiago, Chile.
C3 Universidad de Chile; Clinica Alemana; Pontificia Universidad Catolica
   de Chile; Universidad del Desarrollo; Pontificia Universidad Catolica de
   Chile; Pontificia Universidad Catolica de Chile
RP Baudrand, R (corresponding author), Pontificia Univ Catolica Chile, Sch Med, Diagonal Paraguay 362,4th Floor, Santiago 8330074, Chile.
EM rbaudran@uc.cl
RI Carrasco, Carmen/KBQ-6227-2024; Carvajal, Cristian/HLH-7846-2023;
   Undurraga, Juan/F-3438-2012
OI Baudrand, Rene/0000-0002-8655-4957; Undurraga, Juan/0000-0001-6958-2369;
   Carvajal, Cristian/0000-0002-0668-412X
FU Fondecyt [1150437, 1150327, 1160695, 1160836, 13CTI-21526-P1, PIA
   ACT1414, FONDECYT 1160736, 1180358]; CONICYT
FX Fondecyt 1150437, 1150327, 1160695, 1160836, Corfo 13CTI-21526-P1, PIA
   ACT1414, FONDECYT 1160736, 1180358 from CONICYT (to JU).
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NR 35
TC 3
Z9 3
U1 0
U2 2
PU MAGHIRA & MAAS PUBLICATIONS
PI MUNSBACH
PA MAGHIRA & MAAS S A R L, 6C, RUE GABRIEL LIPPMANN, L-5365 MUNSBACH,
   LUXEMBOURG
SN 0172-780X
J9 NEUROENDOCRINOL LETT
JI Neuroendocrinol. Lett.
PY 2018
VL 39
IS 4
BP 288
EP 293
AR PMID 30531699
PG 6
WC Endocrinology & Metabolism; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Neurosciences & Neurology
GA HE3UV
UT WOS:000453287500003
PM 30531699
DA 2025-06-11
ER

PT J
AU Kaski, JC
   Garcia, LFV
AF Kaski, JC
   Garcia, LFV
TI Therapeutic options for the management of patients with cardiac syndrome
   X
SO EUROPEAN HEART JOURNAL
LA English
DT Review
DE syndrome X; chest pain and normal coronary arteriograms; angina
ID NORMAL CORONARY-ARTERIES; ELECTRICAL NERVE-STIMULATION; EXERCISE-INDUCED
   ANGINA; ST-SEGMENT DEPRESSION; NONCARDIAC CHEST PAIN; CONVERTING
   ENZYME-INHIBITION; COGNITIVE-BEHAVIORAL THERAPY; QUALITY-OF-LIFE;
   MICROVASCULAR ANGINA; PSYCHOLOGICAL TREATMENT
C1 St George Hosp, Sch Med, Dept Cardiol Sci, Coronary Artery Dis Res Unit, London SW17 0RE, England.
C3 City St Georges, University of London
RP Kaski, JC (corresponding author), St George Hosp, Sch Med, Dept Cardiol Sci, Coronary Artery Dis Res Unit, Cranmer Terrace, London SW17 0RE, England.
RI Kaski, Juan Carlos/LKM-8031-2024
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NR 66
TC 45
Z9 50
U1 0
U2 1
PU W B SAUNDERS CO LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 0195-668X
J9 EUR HEART J
JI Eur. Heart J.
PD FEB
PY 2001
VL 22
IS 4
BP 283
EP 293
DI 10.1053/euhj.2000.2152
PG 11
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 401EB
UT WOS:000166913400007
PM 11161946
OA Bronze
DA 2025-06-11
ER

PT J
AU Kararti, C
   Basat, HÇ
   Özsoy, I
   Özyurt, F
   Özsoy, G
   Kodak, MI
   Özüdogru, A
   Uçar, I
AF Kararti, Caner
   Basat, Hakki Cagdas
   Ozsoy, Ismail
   Ozyurt, Fatih
   Ozsoy, Gulsah
   Kodak, Muhammed Ihsan
   Ozudogru, Anil
   Ucar, Ilyas
TI Biopsychosocial Approach in Identifying Risk Factors of Kinesiophobia in
   Persons with Subacromial Pain Syndrome and Developing a Clinical
   Prediction Tool
SO INDIAN JOURNAL OF ORTHOPAEDICS
LA English
DT Article
DE Subacromial pain syndrome; Shoulder; Painful shoulder; Biopsychosocial
   models
ID LOW-BACK-PAIN; QUALITY-OF-LIFE; FEAR-AVOIDANCE BELIEFS; SHOULDER PAIN;
   PSYCHOLOGICAL-FACTORS; METABOLIC SYNDROME; ROTATOR CUFF; IMPINGEMENT
   SYNDROME; TREATMENT EXPECTANCY; MOVEMENT (RE)INJURY
AB Introduction Although the negative effects of kinesiophobia on functional status in subacromial pain syndrome (SAPS) patients are clearly demonstrated, no study examines the risk factors of kinesiophobia in individuals with SAPS from a biopsychosocial perspective. The present study aims to determine the risk factors of kinesiophobia in individuals with SAPS using a biopsychosocial approach. This study also aims to explore the compounding effects of multiple associative risk factors by developing a clinical prediction tool to identify SAPS patients at higher risk for kinesiophobia. Materials and methods This cross-sectional study included 549 patients who were diagnosed with SAPS. The Tampa-Scale of Kinesiophobia (TSK) was used to assess kinesiophobia. Visual analog scale (VAS), The Shoulder Pain and Disability Index (SPADI), Disabilities of the Arm, Shoulder, and Hand (DASH) questionnaire, the presence of metabolic syndrome, using any non-steroidal anti-inflammatory drugs, Pain Catastrophizing Scale (PCS), Illness Perception Questionnaire-revised (IPQ-R), Hospital Anxiety and Depression Scale (HADS), behavioral pattern of the patient, sociodemographic characteristics, and treatment expectancy were outcome measures. Results Thirteen significant risk factors of having kinesiophobia were: VAS(at rest) (>= 5.2), VAS(during activity) (>= 7.1), DASH (>= 72.1), presence of metabolic syndrome, PCShelplessness (>= 16.1), IPQ-R-personal control (<= 17.1), IPQ-R-treatment control (<= 16.3), HADS(depression) (>= 7.9), avoidance behavior type, being female, educational level (<= high school), average hours of sleep (<= 6.8), and treatment expectancy (<= 6.6). The presence of seven or more risk factors increased the probability of having high level of kinesiophobia from 34.3 to 51%. Conclusions It seems necessary to address these factors, increase awareness of health practitioners and individuals.
C1 [Kararti, Caner; Kodak, Muhammed Ihsan; Ozudogru, Anil] Kirsehir Ahi Evran Univ, Dept Physiotherapy & Rehabil, Kirsehir, Turkey.
   [Basat, Hakki Cagdas] Kirsehir Ahi Evran Univ, Dept Orthoped & Traumatol, Kirsehir, Turkey.
   [Ozsoy, Ismail; Ozsoy, Gulsah] Selcuk Univ, Dept Physiotherapy & Rehabil, Konya, Turkey.
   [Ozyurt, Fatih] Beykent Univ, Dept Physiotherapy & Rehabil, Istanbul, Turkey.
   [Ucar, Ilyas] Erciyes Univ, Dept Anat, Kayseri, Turkey.
C3 Kirsehir Ahi Evran University; Kirsehir Ahi Evran University; Selcuk
   University; Beykent University; Erciyes University
RP Kararti, C (corresponding author), Kirsehir Ahi Evran Univ, Dept Physiotherapy & Rehabil, Kirsehir, Turkey.
EM fzt.caner.92@gmail.com; cagdasbasat@gmail.com; ozsoy.ismail@yahoo.com;
   fatih.ozyurt10@gmail.com; fzt.gulsah@hotmail.com; kodakihsan@gmail.com;
   aozudogru@hotmail.com; fzt.iducar@hotmail.com
RI UÇAR, İlyas/AAE-4052-2021; KARARTI, Caner/AAH-4943-2019; OZSOY,
   Gulsah/IZQ-0119-2023; Kodak, Muhammed/ADQ-7342-2022; Ozsoy,
   Ismail/AFS-1649-2022; basat, hakkı/D-5703-2019; Özüdoğru,
   Anıl/JWA-0256-2024; ÖZYURT, Fatih/ADC-1396-2022
OI Ozsoy, Gulsah/0000-0001-5678-771X; OZYURT, Fatih/0000-0002-0201-9798;
   BASAT, Cagdas/0000-0003-3301-2529; KODAK, Muhammed
   Ihsan/0000-0001-7164-5162; ucar, ilyas/0000-0003-3646-5320; KARARTI,
   CANER/0000-0002-4655-0986
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NR 89
TC 6
Z9 7
U1 1
U2 15
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0019-5413
EI 1998-3727
J9 INDIAN J ORTHOP
JI Indian J. Orthop.
PD JAN
PY 2023
VL 57
IS 1
BP 124
EP 136
DI 10.1007/s43465-022-00781-7
EA NOV 2022
PG 13
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA 8A5BD
UT WOS:000888718000001
PM 36660479
OA Green Published
DA 2025-06-11
ER

PT J
AU Zhao, Y
   Tang, YZ
   Liu, SJ
   Jia, TT
   Zhou, DG
   Xu, HY
AF Zhao, Yu
   Tang, Yizhou
   Liu, Shanji
   Jia, Tiantian
   Zhou, Donggen
   Xu, Hengyi
TI Foodborne TiO2 Nanoparticles Induced More Severe
   Hepatotoxicity in Fructose-Induced Metabolic Syndrome Mice via
   Exacerbating Oxidative Stress-Mediated Intestinal Barrier Damage
SO FOODS
LA English
DT Article
DE titanium dioxide nanoparticles; fructose; metabolic syndrome;
   hepatotoxicity; intestinal barrier
ID TITANIUM-DIOXIDE NANOPARTICLES; NONALCOHOLIC FATTY LIVER; IN-VIVO;
   APOPTOSIS; FOOD; INFLAMMATION; PATHOGENESIS; EXPOSURE; IMPACT; RATS
AB The hazard of titanium dioxide nanoparticles (TiO2 NPs) in diseased population should be given focus due to the huge number of these NPs in foods and medicine. This study aimed to evaluate the stronger biological adverse effect of oral exposure to TiO2 NPs in a fructose-induced metabolic syndrome mouse model. Compared to the normal mice, low-dose (2 mg/kg) TiO2 NPs did not cause severe hepatotoxicity. However, high-dose (20 mg/kg) TiO2 NPs induced aggravated hepatic inflammation, fibrosis, and apoptosis, with substantial alteration of related biochemical parameters in the mouse model. Moreover, significantly increased Ti and lipopolysaccharide burden were observed in metabolic syndrome murine liver and serum, which possibly worsened the portend intestinal leakage. The expression of tight junction-related protein showed that TiO2 NPs induced further increase in serious intestinal permeability. The intestinal inflammatory and oxidative stress response in the model were also assessed. Results showed that TiO2 NPs caused more severe intestinal inflammatory injury by intensifying the oxidative stress in metabolic syndrome mice and then induced further liver injury. This work provides information on the insights into the toxic effect of TiO2 NPs in sub-healthy population.
C1 [Zhao, Yu; Tang, Yizhou; Liu, Shanji; Jia, Tiantian; Xu, Hengyi] Nanchang Univ, State Key Lab Food Sci & Technol, Nanchang 330047, Jiangxi, Peoples R China.
   [Zhou, Donggen] Ningbo Int Travel HealthCare Ctr, Ningbo 315012, Peoples R China.
C3 Nanchang University
RP Xu, HY (corresponding author), Nanchang Univ, State Key Lab Food Sci & Technol, Nanchang 330047, Jiangxi, Peoples R China.; Zhou, DG (corresponding author), Ningbo Int Travel HealthCare Ctr, Ningbo 315012, Peoples R China.
EM 5603515014@email.ncu.edu.cn; 402313318102@email.ncu.edu.cn;
   412314919032@email.ncu.edu.cn; 7901119160@email.ncu.edu.cn;
   402337519032@email.ncu.edu.cn; HengyiXu@ncu.edu.cn
RI Jia, Tiantian/P-7755-2018; zhou, donggen/JMR-4014-2023; Zhao,
   Yu/LFV-4144-2024
OI Xu, Hengyi/0000-0003-0457-9665
FU National Natural Science Foundation of China [82060606]; Natural Science
   Foundation of Ningbo, China [2017C50034]
FX This work was supported by National Natural Science Foundation of China
   (82060606), and Natural Science Foundation of Ningbo, China
   (2017C50034).
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NR 40
TC 22
Z9 21
U1 1
U2 28
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2304-8158
J9 FOODS
JI Foods
PD MAY
PY 2021
VL 10
IS 5
AR 986
DI 10.3390/foods10050986
PG 17
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA SH0ZB
UT WOS:000653864900001
PM 33946424
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Petek, TH
   Varda, NM
AF Petek, Tjasa Hertis
   Varda, Natasa Marcun
TI Childhood Cardiovascular Health, Obesity, and Some Related Disorders:
   Insights into Chronic Inflammation and Oxidative Stress
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE cardiovascular health; obesity; obesity-related comorbidities; chronic
   inflammation; oxidative stress; child
ID INTIMA-MEDIA THICKNESS; DYNAMIC THIOL/DISULPHIDE HOMEOSTASIS; HIGH
   BLOOD-PRESSURE; METABOLIC SYNDROME; RISK-FACTORS; WAIST CIRCUMFERENCE;
   CVD RISK; CHILDREN; MARKERS; DISEASE
AB Childhood obesity and associated metabolic abnormalities have become pressing public health concerns worldwide, significantly impacting cardiovascular health. Metabolic syndrome, characterized by a cluster of metabolic abnormalities including central obesity, altered glucose metabolism, dyslipidemia, and arterial hypertension, has emerged as a critical precursor to cardiovascular disease. Chronic systemic inflammation and oxidative stress seem to play pivotal roles in the pathogenesis of childhood obesity-related disorders such as early atherosclerosis. A significant distinction between the objective components of cardiovascular health metrics, including body mass index, blood pressure, cholesterol, and fasting glucose levels, and the definition of metabolic syndrome is evident in the identification of obesity. Whereas cardiovascular health metrics predominantly rely on body mass index percentiles to assess obesity, metabolic syndrome criteria prioritize waist circumference, specifically targeting individuals with a measurement >= 90th percentile. This discrepancy emphasizes the need for a nuanced approach in assessing the risks associated with obesity and underscores the importance of considering multiple factors when evaluating cardiovascular risk in children. By recognizing the complex interplay between various health metrics, obesity and metabolic syndrome criteria, clinicians can more accurately identify individuals at risk and tailor interventions accordingly to mitigate cardiovascular disease in children with obesity.
C1 [Petek, Tjasa Hertis; Varda, Natasa Marcun] Univ Med Ctr Maribor, Dept Paediat, Ljubljanska Ulica 5, Maribor 2000, Slovenia.
   [Varda, Natasa Marcun] Univ Maribor, Fac Med, Taborska Ulica 8, Maribor 2000, Slovenia.
C3 University of Maribor; University of Maribor
RP Varda, NM (corresponding author), Univ Med Ctr Maribor, Dept Paediat, Ljubljanska Ulica 5, Maribor 2000, Slovenia.; Varda, NM (corresponding author), Univ Maribor, Fac Med, Taborska Ulica 8, Maribor 2000, Slovenia.
EM tjasa.hertispetek@ukc-mb.si; natasa.marcunvarda@ukc-mb.si
OI Marcun Varda, Natasa/0000-0003-0634-3576
FU University Medical Center Maribor
FX This review received no external funding. The article processing charges
   were funded by the University Medical Center Maribor.
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NR 121
TC 6
Z9 6
U1 7
U2 12
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD SEP
PY 2024
VL 25
IS 17
AR 9706
DI 10.3390/ijms25179706
PG 17
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA F6Q1Y
UT WOS:001311036000001
PM 39273654
OA gold
DA 2025-06-11
ER

PT J
AU Alembagheri, A
   Hajimehdipoor, H
   Choopani, R
   Esmaeili, S
AF Alembagheri, Akram
   Hajimehdipoor, Homa
   Choopani, Rasool
   Esmaeili, Somayeh
TI The role of selected medicinal plants from Iranian traditional medicine
   for the treatment of fatigue in metabolic syndrome
SO TRADITIONAL MEDICINE RESEARCH
LA English
DT Review
DE medicinal plants; fatigue; metabolic syndrome; Iranian traditional
   medicine; Persian medicine
ID PISTACIA-TEREBINTHUS L.; IN-VITRO EVALUATION; ANETHUM-GRAVEOLENS;
   ANTIOXIDANT ACTIVITY; ALPHA-AMYLASE; CHEMICAL-COMPOSITION;
   LAWSONIA-INERMIS; CHAMOMILE TEA; ANTIINFLAMMATORY ACTIVITY;
   PHENOLIC-COMPOUNDS
AB Background: Fatigue is a symptom of metabolic disorders such as metabolic syndrome, which is currently increasing in the world. There is no specific medication for fatigue, but in many cases, such as in metabolic disorders, it can be relieved by treating the underlying causes. Oxidative stress and inflammation are associated with fatigue and metabolic syndrome. Other mechanisms in metabolic syndrome are also involved in causing fatigue. Objective: The aim of this study was to investigate the role of selected medicinal plants from Iranian traditional medicine (ITM) in improving fatigue in patients with metabolic syndrome. Methods: ITM is one of the most ancient systems of medicine. In this article, we first explained fatigue, its types, and treatment from the perspective of ITM and then introduced a list of medicinal plants used in ITM to treat fatigue. Next, we reviewed the biological effects of these plants effective in treating the manifestations of the metabolic syndrome based on a search of electronic databases. Results: They have antioxidant, anti-inflammatory, and anti-diabetic activities. Among them, Matricaria chamomilla L., Laurus nobilis L., Origanum majorana L., Vitex agnus-castus L., Lawsonia inermis L., Anethum graveolens L., and Pistacia terebinthus L. improve the lipid profile and reduce dyslipidemia. Also, the antihypertensive effects of Matricaria chamomilla, Laurus nobilis, and Origanum majorana have been proven. Conclusion: These plants prevent fatigue and disease progression by countering oxidative stress and inflammation and affecting the properties of the metabolic syndrome.
C1 [Alembagheri, Akram] Shahid Beheshti Univ Med Sci, Student Res Comm, Sch Tradit Med, Dept Tradit Pharm, Tehran 1516745811, Iran.
   [Hajimehdipoor, Homa; Esmaeili, Somayeh] Shahid Beheshti Univ Med Sci, Tradit Med & Mat Med Res Ctr, Sch Tradit Med, Dept Tradit Pharm, Tehran 1516745811, Iran.
   [Choopani, Rasool] Shahid Beheshti Univ Med Sci, Sch Tradit Med, Dept Tradit Med, Tehran 1516745811, Iran.
   [Esmaeili, Somayeh] Shahid Beheshti Univ Med Sci, Tradit Med & Mat Med Res Ctr, Sch Tradit Med, Dept Tradit Pharm, 08 Shams Alley,Shahid Abbaspour St,Vali Asr Ave, Tehran 1516745811, Iran.
C3 Shahid Beheshti University Medical Sciences; Shahid Beheshti University
   Medical Sciences; Shahid Beheshti University Medical Sciences; Shahid
   Beheshti University Medical Sciences
RP Esmaeili, S (corresponding author), Shahid Beheshti Univ Med Sci, Tradit Med & Mat Med Res Ctr, Sch Tradit Med, Dept Tradit Pharm, 08 Shams Alley,Shahid Abbaspour St,Vali Asr Ave, Tehran 1516745811, Iran.
EM sesmaeili@sbmu.ac.ir
RI Esmaeili, Somayeh/H-1306-2017; Alembagheri, Akram/HLW-5546-2023
OI Alembagheri, Akram/0000-0001-9223-3343
FU Student Research Committee, Shahid Beheshti University of Medical
   Sciences, Tehran, Iran [1399/60857]; Student Research Committee and
   Research & Technology Chancellor
FX This study is related to the project No. 1399/60857 from Student
   Research Committee, Shahid Beheshti University of Medical Sciences,
   Tehran, Iran. We also appreciate the "Student Research Committee" and
   "Research & Technology Chancellor" in Shahid Beheshti University of
   Medical Sciences for their financial support of this study.
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SN 2413-3973
J9 TRADIT MED RES
JI Tradit. Med. Res.
PD APR 1
PY 2023
VL 8
IS 4
AR 23
DI 10.53388/TMR20220706001
PG 15
WC Integrative & Complementary Medicine
WE Emerging Sources Citation Index (ESCI)
SC Integrative & Complementary Medicine
GA 8W4YG
UT WOS:000931339700006
OA hybrid
DA 2025-06-11
ER

PT J
AU Nolan, CJ
   Prentki, M
AF Nolan, Christopher J.
   Prentki, Marc
TI Insulin resistance and insulin hypersecretion in the metabolic syndrome
   and type 2 diabetes: Time for a conceptual framework shift
SO DIABETES & VASCULAR DISEASE RESEARCH
LA English
DT Review
DE Cardiovascular diseases; insulin hypersecretion; insulin-mediated
   metabolic stress; insulin resistance; metabolic syndrome; non-alcoholic
   fatty liver disease; polycystic ovary syndrome; type 2 diabetes
ID MALONYL-COA; OBESITY; SECRETION; HEART; RISK; GLUCOLIPOTOXICITY;
   HYPERINSULINEMIA; COMPLICATIONS; SENSITIVITY; OUTCOMES
AB While few dispute the existence of the metabolic syndrome as a clustering of factors indicative of poor metabolic health, its utility above that of its individual components in the clinical care of individual patients is questioned. This is likely a consequence of the failure of clinicians and scientists to agree on a unifying mechanism to explain the metabolic syndrome. Insulin resistance has most commonly been proposed for this role and is generally considered to be a root causative factor for not only metabolic syndrome but also for its associated conditions of non-alcoholic fatty liver disease (NAFLD), polycystic ovary syndrome (PCOS), obesity-related type 2 diabetes (T2D) and atherosclerotic cardiovascular disease (ASCVD). An alternative view, for which evidence is mounting, is that hyper-responsiveness of islet beta-cells to a hostile environment, such as westernised lifestyle, is primary and that the resulting hyperinsulinaemia drives the other components of the metabolic syndrome. Importantly, within this new conceptual framework, insulin resistance, while always a biomarker and state of poor metabolic health, is not considered to be harmful, but a protective adaptive response of critical tissues including the myocardium against insulin-induced metabolic stress. This major shift in how metabolic syndrome can be considered puts insulin hypersecretion into position as the unifying mechanism. If shown to be correct, this new conceptual framework has major implications for the future prevention and management of the metabolic syndrome, including its associated conditions of NAFLD, PCOS, obesity-related T2D and ASCVD.
C1 [Nolan, Christopher J.] Canberra Hosp, Dept Endocrinol, Yamba Dr, Garran, ACT 2606, Australia.
   [Nolan, Christopher J.] Australian Natl Univ, Sch Med, Canberra, ACT, Australia.
   [Nolan, Christopher J.] Australian Natl Univ, John Curtin Sch Med Res, Canberra, ACT, Australia.
   [Prentki, Marc] CRCHUM, 900 St Denis,Room R08-412, Montreal, PQ H2X 0A9, Canada.
   [Prentki, Marc] Univ Montreal, Montreal Diabet Res Ctr, 900 St Denis,Room R08-412, Montreal, PQ H2X 0A9, Canada.
   [Prentki, Marc] Univ Montreal, Dept Nutr, Montreal, PQ, Canada.
   [Prentki, Marc] Univ Montreal, Dept Biochem & Mol Med, Montreal, PQ, Canada.
C3 Australian National University; Canberra Hospital; Australian National
   University; Australian National University; John Curtin School of
   Medical Research; Universite de Montreal; Universite de Montreal;
   Universite de Montreal; Universite de Montreal
RP Nolan, CJ (corresponding author), Canberra Hosp, Dept Endocrinol, Yamba Dr, Garran, ACT 2606, Australia.; Prentki, M (corresponding author), CRCHUM, 900 St Denis,Room R08-412, Montreal, PQ H2X 0A9, Canada.; Prentki, M (corresponding author), Univ Montreal, Montreal Diabet Res Ctr, 900 St Denis,Room R08-412, Montreal, PQ H2X 0A9, Canada.
EM christopher.nolan@anu.edu.au; marc.prentki@umontreal.ca
RI Prentki, Marc/LBI-2401-2024; Nolan, Christopher J/B-2026-2008
OI Nolan, Christopher J/0000-0002-6964-3819
FU Canadian Institutes of Health Research; National Health and Medical
   Research Council [1128442]; National Health and Medical Research Council
   of Australia [1128442] Funding Source: NHMRC
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship and/or publication of this article: This work
   was supported in part by grants from the Canadian Institutes of Health
   Research (M.P.) and the National Health and Medical Research Council
   [project grant 1128442 (C.J.N.)].
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NR 55
TC 174
Z9 194
U1 1
U2 30
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1479-1641
EI 1752-8984
J9 DIABETES VASC DIS RE
JI Diabetes Vasc. Dis. Res.
PD MAR
PY 2019
VL 16
IS 2
SI SI
BP 118
EP 127
DI 10.1177/1479164119827611
PG 10
WC Endocrinology & Metabolism; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Cardiovascular System & Cardiology
GA HU9DG
UT WOS:000465592900003
PM 30770030
OA Bronze
DA 2025-06-11
ER

PT J
AU Chojnacki, C
   Walecka-Kapica, E
   Klupinska, G
   Pawlowicz, M
   Blonska, A
   Chojnacki, J
AF Chojnacki, C.
   Walecka-Kapica, E.
   Klupinska, G.
   Pawlowicz, M.
   Blonska, A.
   Chojnacki, J.
TI EFFECTS OF FLUOXETINE AND MELATONIN ON MOOD, SLEEP QUALITY AND BODY MASS
   INDEX IN POSTMENOPAUSAL WOMEN
SO JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
LA English
DT Article
DE menopause; appetite disorders; body mass index; fluoxetine; melatonin;
   anxiety; depression; sleep quality
ID DUODENAL BICARBONATE SECRETION; HORMONE-THERAPY; METABOLIC SYNDROME;
   GASTRIC-SECRETION; INDUCED ANOREXIA; OBESE-PATIENTS; PLASMA LEPTIN;
   DOUBLE-BLIND; FOOD-INTAKE; SEROTONIN
AB Frequent mood and sleep disorders and increased appetite leading to obesity are observed in postmenopausal women. Due to the limitations of hormone replacement therapy the researchers look for other treatment regimes. The aim of the study was to evaluate the efficacy of fluoxetine and melatonin in the treatment of these disorders.The study included 64 overweight postmenopausal women, aged 54 - 65 years, with increased appetite. They were randomly assigned in 2 groups. In group I (n = 30) fluoxetine (20 mg in the morning) and placebo (in the evening) were administered for 24 weeks. Group II (n = 34) received fluoxetine (20 mg in the morning) and melatonin (5 mg in the evening) in the same period of time. Hamilton anxiety rating scale (HARS), Beck depression scale (BDI), the insomnia severity index (ISI) and body mass index (BMI) were used to assess the health status and the treatment efficacy. After 24 weeks, comparable and statistically significant reduction in the level of anxiety and depression was obtained in both groups. In group I, the ISI decreased from 14.9 +/- 2.5 points to 10.9 +/- 1.9 points (P < 0.05) and in group II from 15.8 +/- 2.4 points to 7.7 +/- 1.5 points (P < 0.001). In group I no reduction in BMI was achieved whereas in group II this index decreased from 30.9 +/- 3.1 to 26.3 +/- 3.2 (P < 0.05). We conclude that combined administration of fluoxetine and melatonin was useful option to treat mood, sleep and appetite disorders in postmenopausal women.
C1 [Chojnacki, C.; Walecka-Kapica, E.; Klupinska, G.; Blonska, A.] Med Univ Lodz, Dept Clin Nutr & Gastroenterol Diagnost, PL-90647 Lodz, Poland.
   [Pawlowicz, M.; Chojnacki, J.] Med Univ Lodz, Dept Gastroenterol, PL-90647 Lodz, Poland.
C3 Medical University Lodz; Medical University Lodz
RP Chojnacki, C (corresponding author), Med Univ Lodz, Dept Clin Nutr & Gastroenterol Diagnost, 1 Haller Sq, PL-90647 Lodz, Poland.
EM cezary.chojnacki@umed.lodz.pl
RI Chojnacki, Jan/S-9901-2016; Walecka-Kapica, Ewa/W-1049-2018
OI Chojnacki, Jan/0000-0001-8766-7868; Walecka-Kapica,
   Ewa/0000-0003-0838-4208; Chojnacki, Cezary/0000-0002-1620-4775
FU Ministry of Science and Higher Education in Poland [NN-4025437/40]
FX The study was supported by the grant of The Ministry of Science and
   Higher Education in Poland, (NN-4025437/40).
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NR 79
TC 38
Z9 39
U1 0
U2 14
PU POLISH PHYSIOLOGICAL SOC
PI GRZEGORZECKA
PA JAGIELLONIAN UNIV SCHOOL MED, INST PHYSIOLOGY, 31-531 KRAKOW, 16
   GRZEGORZECKA, POLAND
SN 0867-5910
J9 J PHYSIOL PHARMACOL
JI J. Physiol. Pharmacol.
PD OCT
PY 2015
VL 66
IS 5
BP 665
EP 671
PG 7
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA CZ6MS
UT WOS:000367216000005
PM 26579572
DA 2025-06-11
ER

PT J
AU Seda, O
   Sedová, L
   Vcelák, J
   Vanková, M
   Liska, F
   Bendlová, B
AF Seda, O.
   Sedova, L.
   Vcelak, J.
   Vankova, M.
   Liska, F.
   Bendlova, B.
TI ZBTB16 and Metabolic Syndrome: a Network Perspective
SO PHYSIOLOGICAL RESEARCH
LA English
DT Review
DE Metabolic syndrome; Systems biology; Pleiotropy; Animal models
ID LEUKEMIA ZINC-FINGER; ACID-INDUCED DYSLIPIDEMIA; GENOME-WIDE
   ASSOCIATION; MESENCHYMAL STEM-CELLS; TRANSCRIPTIONAL REPRESSION;
   UPSTREAM REGULATOR; INSULIN-RESISTANCE; GENE-EXPRESSION;
   DOWN-REGULATION; PROTEIN PLZF
AB Metabolic syndrome is a prevalent, complex condition. The search for genetic determinants of the syndrome is currently undergoing a paradigm enhancement by adding systems genetics approaches to association studies. We summarize the current evidence on relations between an emergent new candidate, zinc finger and BTB domain containing 16 (ZBTB16) transcription factor and the major components constituting the metabolic syndrome. Information stemming from studies on experimental models with altered Zbtb16 expression clearly shows its effect on adipogenesis, cardiac hypertrophy and fibrosis, lipid levels and insulin sensitivity. Based on current evidence, we provide a network view of relations between ZBTB16 and hallmarks of metabolic syndrome in order to elucidate the potential functional links involving the ZBTB16 node. Many of the identified genes interconnecting ZBTB16 with all or most metabolic syndrome components are linked to immune function, inflammation or oxidative stress. In summary, ZBTB16 represents a promising pleiotropic candidate node for metabolic syndrome.
C1 [Seda, O.; Sedova, L.; Liska, F.] Charles Univ Prague, Fac Med 1, Inst Biol & Med Genet, Prague, Czech Republic.
   [Sedova, L.] Czech Acad Sci, Inst Mol Genet, Div BIOCEV, Lab Transgen Models Dis, Vestec, Czech Republic.
   [Vcelak, J.; Vankova, M.; Bendlova, B.] Inst Endocrinol, Dept Mol Endocrinol, Prague, Czech Republic.
C3 Charles University Prague; Czech Academy of Sciences; Institute of
   Molecular Genetics of the Czech Academy of Sciences; Institute of
   Endocrinology - Prague
RP Bendlová, B (corresponding author), Inst Endocrinol, Narodni 8, Prague 11694 1, Czech Republic.
EM bbendlova@endo.cz
RI Liska, Frantisek/N-9192-2017; Vcelak, Josef/MAH-6912-2025; Seda,
   Ondrej/A-2058-2008
OI Seda, Ondrej/0000-0001-8498-5895
FU Czech Science Foundation [15-04871S]; Charles University [Q25/LF1]; MH
   CR - DRO (Institute of Endocrinology) [00023761]; MEYS CR (OP RDE,
   Excellent research - ENDO.CZ)
FX This work was supported by Czech Science Foundation Project 15-04871S
   and Charles University (Progres Q25/LF1), and by MH CR - DRO 00023761
   (Institute of Endocrinology) and by the MEYS CR (OP RDE, Excellent
   research - ENDO.CZ).
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NR 59
TC 33
Z9 35
U1 0
U2 13
PU ACAD SCIENCES CZECH REPUBLIC, INST PHYSIOLOGY
PI PRAGUE 4
PA VIDENSKA 1083, PRAGUE 4 142 20, CZECH REPUBLIC
SN 0862-8408
EI 1802-9973
J9 PHYSIOL RES
JI Physiol. Res.
PY 2017
VL 66
SU 3
BP S357
EP S365
DI 10.33549/physiolres.933730
PG 9
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA FJ4UK
UT WOS:000412737900010
PM 28948820
OA gold
DA 2025-06-11
ER

PT J
AU Dziegielewska-Gesiak, S
   Wysocka, E
   Fatyga, E
   Muc-Wierzgon, M
AF Dziegielewska-Gesiak, Sylwia
   Wysocka, Ewa
   Fatyga, Edyta
   Muc-Wierzgon, Malgorzata
TI Relationship of SOD-1 Activity in Metabolic Syndrome and/or Frailty in
   Elderly Individuals
SO METABOLITES
LA English
DT Article
DE aging; metabolic syndrome; frailty syndrome; SOD-1
ID SUPEROXIDE-DISMUTASE; OXIDATIVE STRESS; MORTALITY
AB Introduction: Although aging is a natural phenomenon, in recent years it has accelerated. One key factor implicated in the aging process is oxidative stress. Oxidative stress also plays a role in frailty (frail) and metabolic syndrome (MetS). Methods: A total of 66 elderly persons (65 years old and older) with no acute or severe chronic disorders were assessed for waist circumference (WC), arterial blood pressure, glycemia, glycated hemoglobin (HbA1c), plasma lipids, and activity of erythrocyte superoxide dismutase (SOD-1). Patients were classified as NonMetS-Nonfrail (n = 19), NonMetS-frail (n = 20), MetS-Nonfrail (n = 17), or MetS-frail (n = 10). Results: There were no significant differences in superoxide dismutase activity among investigated elderly groups. However, the data suggest that MetS individuals, both frail and nonfrail, have higher risk factors for cardiovascular disease compared to NonMetS individuals. The correlations analyses of SOD-1 and other metabolic indices suggest that SOD-1 levels may be influenced by age, total cholesterol, HDL cholesterol, and fasting glucose levels in certain groups of seniors. Conclusions: Aging is associated with decreased antioxidant enzyme SOD-1 activity with glucose alteration in frailty syndrome as well as with lipids disturbances in metabolic syndrome. These factors provide a nuanced view of how frailty and metabolic syndrome interact with various health parameters, informing both clinical practice and future research directions.
C1 [Dziegielewska-Gesiak, Sylwia; Fatyga, Edyta; Muc-Wierzgon, Malgorzata] Med Univ Silesia, Fac Publ Hlth Bytom, Dept Internal Dis Propaedeut & Emergency Med, Piekarska 18 Str, PL-44902 Bytom, Poland.
   [Wysocka, Ewa] Poznan Univ Med Sci, Dept Lab Diagnost, 84 Szamarzewskiego Str, PL-60569 Poznan, Poland.
C3 Medical University of Silesia; Poznan University of Medical Sciences
RP Dziegielewska-Gesiak, S (corresponding author), Med Univ Silesia, Fac Publ Hlth Bytom, Dept Internal Dis Propaedeut & Emergency Med, Piekarska 18 Str, PL-44902 Bytom, Poland.
EM sgesiak@sum.edu.pl; ewysocka@ump.edu.pl; efatyga@sum.edu.pl;
   mwierzgon@sum.edu.pl
RI Dzięgielewska-Gesiak, Sylwia/IYS-6186-2023
OI Muc-Wierzgon, Malgorzata/0000-0001-6562-7072; Dziegielewska-Gesiak,
   Sylwia/0000-0003-1019-5959; Fatyga, Edyta/0000-0003-0389-206X
FU Medical University of Silesia;  [PCN-1-210/N/2/0]
FX The APC was funded by Medical University of Silesia, grant no.:
   PCN-1-210/N/2/0.
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NR 55
TC 2
Z9 2
U1 3
U2 4
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2218-1989
J9 METABOLITES
JI Metabolites
PD SEP
PY 2024
VL 14
IS 9
AR 514
DI 10.3390/metabo14090514
PG 13
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA H5J8O
UT WOS:001323812100001
PM 39330521
OA gold
DA 2025-06-11
ER

PT J
AU Silic, A
   Karlovic, D
   Serretti, A
AF Silic, Ante
   Karlovic, Dalibor
   Serretti, Alessandro
TI Increased inflammation and lower platelet 5-HT in depression with
   metabolic syndrome
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Major depressive disorder; Metabolic syndrome; Interleukin 6; C-reactive
   protein; Platelet serotonin
ID C-REACTIVE PROTEIN; INSULIN-RESISTANCE; SEROTONERGIC RESPONSIVITY;
   RECEPTOR GENE; SYMPTOMS; OBESITY; ANTIDEPRESSANTS; ASSOCIATION; HEALTH;
   WOMEN
AB Background: Recent studies suggest comorbidity between major depressive disorder (MDD) and metabolic syndrome. For both disorders, impaired serotoninergic neurotransmission and inflammatory factors have been suggested. The objective of this study was to investigate the concentration of platelet serotonin, interleukin-6 (IL-6) and C-reactive protein (CRP) in MDD patients with and without metabolic syndrome. The second goal was to investigate the association of the concentrations of platelet serotonin, IL-6 and CRP with individual components of metabolic syndrome in MDD patients.
   Methods: A total of 145 MDD patients were included in the study (diagnosed according DSM IV TR criteria). The metabolic syndrome was defined according to the criteria of the American National Cholesterol Education Program-Treatment Panel III (ATP III). Inflammation factors (IL-6 and CRP) and platelet serotonin concentration were assessed by the enzyme-linked immunosorbent assay (ELISA).
   Results: MDD patients with metabolic syndrome showed lower platelet serotonin and higher IL-6 and CRP concentrations when compared to MDD patients without metabolic syndrome. An inverse correlation was found between platelet serotonin and waist circumference and serum glucose levels. A positive correlation was found between IL-6 and glucose or triglyceride concentrations, while the correlation with HDL cholesterol was negative. Limitations: Data on dietary habits or physical activity prior to hospitalisation were not collected. Also, the study was a cross-sectional without a prospective design.
   Conclusion: Metabolic syndrome in patients with MDD may be associated with reduced concentrations of platelet serotonin and increased concentrations of IL-6 and CRP. (C) 2012 Elsevier B.V. All rights reserved.
C1 [Karlovic, Dalibor] Univ Hosp Sestre Milosrdnice, Dept Psychiat, Sestre Milosrdnice Univ Hosp Ctr, Zagreb 10000, Croatia.
   [Silic, Ante] Hosp Psychiat, Zagreb, Croatia.
   [Serretti, Alessandro] Univ Bologna, Inst Psychiat, Bologna, Italy.
C3 University of Zagreb; University of Bologna
RP Karlovic, D (corresponding author), Univ Hosp Sestre Milosrdnice, Dept Psychiat, Sestre Milosrdnice Univ Hosp Ctr, Vinogradska Cesta 29, Zagreb 10000, Croatia.
EM dalibor.karlovic@gmail.com
RI ; serretti, alessandro/G-3955-2017
OI Silic, Ante/0000-0003-2840-8836; serretti,
   alessandro/0000-0003-4363-3759
FU Croatian Ministry of Science, Education and Sport [134-0000000-3372]
FX This work was supported by the Croatian Ministry of Science, Education
   and Sport, grant number 134-0000000-3372.
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NR 41
TC 23
Z9 24
U1 0
U2 33
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD DEC 1
PY 2012
VL 141
IS 1
BP 72
EP 78
DI 10.1016/j.jad.2012.02.019
PG 7
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA 011EV
UT WOS:000309148500009
PM 22391518
DA 2025-06-11
ER

PT J
AU Lee, RE
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   Adamus-Leach, HJ
AF Lee, Rebecca E.
   Mama, Scherezade K.
   Adamus-Leach, Heather J.
TI Neighborhood Street Scale Elements, Sedentary Time and Cardiometabolic
   Risk Factors in Inactive Ethnic Minority Women
SO PLOS ONE
LA English
DT Article
ID BODY-MASS INDEX; PHYSICAL-ACTIVITY; CARDIOVASCULAR-DISEASE; PSYCHOSOCIAL
   STRESS; BUILT ENVIRONMENT; AFRICAN-AMERICAN; OBESITY; ADULTS;
   ASSOCIATIONS; ATTRIBUTES
AB Background: Cardiometabolic risk factors such as obesity, excess percent body fat, high blood pressure, elevated resting heart rate and sedentary behavior have increased in recent decades due to changes in the environment and lifestyle. Neighborhood micro-environmental, street scale elements may contribute to health above and beyond individual characteristics of residents.
   Purpose: To investigate the relationship between neighborhood street scale elements and cardiometabolic risk factors among inactive ethnic minority women.
   Method: Women (N = 410) completed measures of BMI, percent body fat, blood pressure, resting heart rate, sedentary behavior and demographics. Trained field assessors completed the Pedestrian Environment Data Scan in participants' neighborhoods. Data were collected from 2006-2008. Multiple regression models were conducted in 2011 to estimate the effect of environmental factors on cardiometabolic risk factors.
   Results: Adjusted regression models found an inverse association between sidewalk buffers and blood pressure, between traffic control devices and resting heart rate, and a positive association between presence of pedestrian crossing aids and BMI (ps<.05). Neighborhood attractiveness and safety for walking and cycling were related to more time spent in a motor vehicle (ps<.05).
   Conclusions: Findings suggest complex relationships among micro-environmental, street scale elements that may confer important cardiometabolic benefits and risks for residents. Living in the most attractive and safe neighborhoods for physical activity may be associated with longer times spent sitting in the car.
C1 [Lee, Rebecca E.; Mama, Scherezade K.; Adamus-Leach, Heather J.] Univ Houston, Dept Hlth & Human Performance, Texas Obes Res Ctr, Houston, TX 77030 USA.
C3 University of Houston System; University of Houston
RP Lee, RE (corresponding author), Univ Houston, Dept Hlth & Human Performance, Texas Obes Res Ctr, Houston, TX 77030 USA.
EM releephd@yahoo.com
RI Leach, Heather/F-9317-2017
FU National Institutes of Health's National Cancer Institute [1R01CA109403]
FX This project was funded by a research grant awarded to Dr. Rebecca E.
   Lee at the University of Houston by the National Institutes of Health's
   National Cancer Institute (1R01CA109403). The funders had no role in
   study design, data collection and analysis, decision to publish.
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NR 43
TC 21
Z9 25
U1 2
U2 30
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD DEC 7
PY 2012
VL 7
IS 12
AR e51081
DI 10.1371/journal.pone.0051081
PG 7
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Science & Technology - Other Topics
GA 050OT
UT WOS:000312064100063
PM 23236434
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Aboonabi, A
   Meyer, RR
   Singh, I
AF Aboonabi, Anahita
   Meyer, Roselyn Rose'
   Singh, Indu
TI The association between metabolic syndrome components and the
   development of atherosclerosis
SO JOURNAL OF HUMAN HYPERTENSION
LA English
DT Review
ID C-REACTIVE PROTEIN; SERUM URIC-ACID; LOW-DENSITY-LIPOPROTEIN;
   CARDIOVASCULAR-DISEASE RISK; MECHANISMS LINKING OBESITY;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; NITRIC-OXIDE; ENDOTHELIAL
   DYSFUNCTION; PLATELET-ADHESION
AB Metabolic syndrome (MetS) is a collection of pathological conditions associated with metabolic, pro-inflammatory, and prothrombotic states. MetS plays an essential role in the atherosclerotic process with associated clustering of risk factors which can increase the risk of atherogenic damage. There is an association between MetS components and the progression of atherosclerosis, which is the leading cause of cardiovascular deaths. This review was undertaken to assess the potential role of metabolic syndrome components, including oxidative stress, hypertension, hyperglycaemia and insulin resistance, obesity, dyslipidemia, chronic inflammation, physical inactivity, and atherogenic diet in the progression of atherosclerosis based on existing research.
C1 [Aboonabi, Anahita; Meyer, Roselyn Rose'; Singh, Indu] Griffith Univ, Sch Med Sci, Gold Coast Campus,Parklands Dr, Southport, Qld 4222, Australia.
C3 Griffith University; Griffith University - Gold Coast Campus
RP Aboonabi, A (corresponding author), Griffith Univ, Sch Med Sci, Gold Coast Campus,Parklands Dr, Southport, Qld 4222, Australia.
EM aa.aboonabi@gmail.com
OI Aboonabi, Anahita/0000-0001-6213-6673; Singh, Indu/0000-0002-0498-4209
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NR 143
TC 80
Z9 87
U1 1
U2 13
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0950-9240
EI 1476-5527
J9 J HUM HYPERTENS
JI J. Hum. Hypertens.
PD DEC
PY 2019
VL 33
IS 12
BP 844
EP 855
DI 10.1038/s41371-019-0273-0
PG 12
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA KG4OF
UT WOS:000509924400004
PM 31636352
DA 2025-06-11
ER

PT J
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   Miyazaki, Takashi
   Sato, Makiko
   Araki, Ryuichiro
   Takahashi, Sachiko
   Takenaka, Tsuneo
   Suzuki, Hiromichi
   Shibazaki, Satomi
TI Lifestyle modifications supported by regional health nurses lowered
   insulin resistance, oxidative stress and central blood pressure in
   subjects with metabolic syndrome
SO OBESITY RESEARCH & CLINICAL PRACTICE
LA English
DT Article
DE Lifestyle modifications; Metabolic syndrome; Insulin resistance;
   Oxidative stress; Blood pressure
ID CARDIOVASCULAR-DISEASE MORTALITY; AUGMENTATION INDEX; PHYSICAL-ACTIVITY;
   WEIGHT-LOSS; INTERVENTION; RISK; INFLAMMATION; OVERWEIGHT; EXERCISE;
   IMPROVES
AB Background: This study was attempted to investigate whether lifestyle modifications supported by regional health nurses should improve cardio-metabolic factors-including adipocytokines, oxidative stress, and arterial stiffness-in subjects with metabolic syndrome.
   Methods: Thirty-six subjects with metabolic syndrome were enrolled, 28 of whom completed the 6-month lifestyle modifications (male: female = 19: 9). Blood and urine test results were examined in relation to metabolic factors before and after 6-month nutritional and physical activity modifications. In addition, oral glucose tolerance tests were performed and arterial stiffness was measured by brachial-ankle pulse wave velocity and radial augmentation index before and after them.
   Results: Six-month lifestyle modifications significantly reduced body weight, homeostasis model assessment index, and low-density lipoprotein cholesterol (LDL-C). They significantly attenuated oxidative stress measured by the urinary 8-hydroxy-2-deoxyguanosine/creatinine ratio. They also lowered brachial and central systolic blood pressure. They tended to decrease waist circumferences and the levels of C-reactive protein. However they did not significantly change the levels of adipocytokines, including tumour necrosis factor, soluble tumour necrosis factor receptors, and interleukin 6, or arterial stiffness measured by brachial-ankle pulse wave velocity and radial augmentation index.
   Conclusions: Six-month lifestyle modifications supported by regional health nurses lowered body weight, insulin resistance, LDL-C, oxidative stress, and peripheral and central blood pressure in subjects with metabolic syndrome. (C) 2015 Asian Oceanian Association for the Study of Obesity. Published by Elsevier Ltd. All rights reserved.
C1 [Ohno, Yoichi; Miyazaki, Takashi; Sato, Makiko; Araki, Ryuichiro; Takahashi, Sachiko; Suzuki, Hiromichi; Shibazaki, Satomi] Saitama Med Univ, Community Hlth Sci Ctr, Saitama, Japan.
   [Ohno, Yoichi; Suzuki, Hiromichi] Saitama Med Univ, Dept Nephrol, Saitama, Japan.
   [Takenaka, Tsuneo] Int Univ Hlth & Welf, Clin Res Ctr, Tokyo, Japan.
C3 Saitama Medical University; Saitama Medical University; International
   University of Health & Welfare
RP Ohno, Y (corresponding author), 38 Moro Hongo, Moroyama, Saitama, Japan.
EM yo1-ohno@bk2.so-net.ne.jp
OI Ohno, Yoichi/0000-0002-0131-4277
CR Ahmed HM, 2012, AM J CARDIOL, V109, P288, DOI 10.1016/j.amjcard.2011.08.042
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NR 33
TC 4
Z9 4
U1 0
U2 4
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1871-403X
EI 1878-0318
J9 OBES RES CLIN PRACT
JI Obes. Res. Clin. Pract.
PD NOV-DEC
PY 2015
VL 9
IS 6
BP 584
EP 591
DI 10.1016/j.orcp.2015.03.003
PG 8
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA CW8HY
UT WOS:000365241300005
PM 25858422
DA 2025-06-11
ER

PT J
AU Nishida, T
   Tsuneyama, K
   Fujimoto, M
   Nomoto, K
   Hayashi, S
   Miwa, S
   Nakajima, T
   Nakanishi, Y
   Hatta, H
   Imura, J
AF Nishida, Takeshi
   Tsuneyama, Koichi
   Fujimoto, Makoto
   Nomoto, Kazuhiro
   Hayashi, Shinichi
   Miwa, Shigeharu
   Nakajima, Takahiko
   Nakanishi, Yuko
   Hatta, Hideki
   Imura, Johji
TI Aberrant iron metabolism might have an impact on progression of diseases
   in Tsumura Suzuki obese diabetes mice, a model of spontaneous metabolic
   syndrome
SO PATHOLOGY INTERNATIONAL
LA English
DT Article
DE aberrant iron metabolism; animal model; excessive iron; ferritin;
   glutathione; metabolic syndrome; oxidative stress; oxidized low-density
   lipoprotein
ID INSULIN-RESISTANCE; NONALCOHOLIC STEATOHEPATITIS;
   HEPATOCELLULAR-CARCINOMA; OXIDATIVE STRESS; SERUM FERRITIN; KUPFFER
   CELLS; HEPATIC IRON; MOUSE MODEL; RISK; STORES
AB Tsumura Suzuki obese diabetes (TSOD) mice spontaneously develop obesity and type 2 diabetes with aberrant accumulation of excessive iron in the spleen. Aberrantly accumulated iron may cause oxidative stress and result in various symptoms of metabolic syndrome in the mice. We investigated iron metabolism and oxidative stress in TSOD mice. Male TSOD and control mice were killed at 2, 3, 6, and 8 months of age, and blood and tissue samples were collected. The serum levels of ferritin and oxidized low-density lipoprotein (OxLDL) were measured. Total glutathione concentrations of liver and spleen were also measured. Serum ferritin and OxLDL were higher in TSOD mice than in control mice at 2 and 6 months. In addition, the glutathione concentrations in TSOD mice were lower in the liver and higher in the spleen at 3 and 6 months than those in control mice. These results suggest that abnormal iron metabolism and imbalanced oxidative stress occurs in young and old TSOD mice. We propose herein that TSOD mice might be a unique and valuable model for investigating the role of iron metabolism in pathogenesis of metabolic syndrome.
C1 [Nishida, Takeshi; Hayashi, Shinichi; Miwa, Shigeharu; Nakajima, Takahiko; Hatta, Hideki; Imura, Johji] Toyama Univ, Grad Sch Med & Pharmaceut Sci, Dept Diagnost Pathol, Toyama, Japan.
   [Fujimoto, Makoto] Toyama Univ, Grad Sch Med & Pharmaceut Sci, Dept Japanese Oriental Med, Toyama, Japan.
   [Nakanishi, Yuko] Toyama Prefectural Cent Hosp, Dept Pathol, Toyama, Japan.
   [Tsuneyama, Koichi] Univ Tokushima, Grad Sch, Inst Biomed Sci, Dept Pathol & Lab Med, 3-18-15 Kuramoto, Tokushima 7708503, Japan.
   [Nomoto, Kazuhiro] Kouseiren Takaoka Hosp, Pathol Lab, Takaoka, Toyama, Japan.
C3 University of Toyama; University of Toyama; Tokushima University
RP Tsuneyama, K (corresponding author), Univ Tokushima, Grad Sch, Inst Biomed Sci, Dept Pathol & Lab Med, 3-18-15 Kuramoto, Tokushima 7708503, Japan.
EM tsuneyama.koichi@tokushima-u.ac.jp
OI Tsuneyama, Koichi/0000-0002-0670-9868
FU TSOD Mouse Research Fund; JSPS KAKENHI Grant [25930018, 15H00465, 15
   K15098, 25340121, 24390181]; Grants-in-Aid for Scientific Research
   [15H00465, 24390181, 25930018] Funding Source: KAKEN
FX The project was supported in part by the TSOD Mouse Research Fund and
   JSPS KAKENHI Grant Numbers 25930018, 15H00465, 15 K15098, 25340121 and
   24390181. We thank Dr. Wataru Suzuki, Dr. Yuko Nakanishi, Yoshiyuki
   Sasaki, Hideki Hatta, Tokimasa Kumada, Akiko Shimomura and Hayato Baba
   for their technical assistance with the experiments. Furthermore, we
   thank Yukari Inoue for her support during the preparation of this
   manuscript.
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NR 40
TC 5
Z9 5
U1 0
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1320-5463
EI 1440-1827
J9 PATHOL INT
JI Pathol. Int.
PD NOV
PY 2016
VL 66
IS 11
BP 622
EP 628
DI 10.1111/pin.12466
PG 7
WC Pathology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pathology
GA EC9IU
UT WOS:000388459100004
PM 27687701
DA 2025-06-11
ER

PT J
AU Gauttam, VK
   Munjal, K
   Chopra, H
   Ahmad, A
   Rana, MK
   Kamal, MA
AF Gauttam, Vinod Kumar
   Munjal, Kavita
   Chopra, Hitesh
   Ahmad, Aftab
   Rana, Mahesh Kumar
   Kamal, Mohammad Amjad
TI A Mechanistic Review on Therapeutic Potential of Medicinal Plants and
   their Pharmacologically Active Molecules for Targeting Metabolic
   Syndrome
SO CURRENT PHARMACEUTICAL DESIGN
LA English
DT Review
DE Metabolic syndrome; phytochemicals; herbal treatment; medicinal plants;
   nutraceuticals; therapeutic potential
ID HIGH-FAT DIET; FACTOR-KAPPA-B; STIMULATES INSULIN-SECRETION; GINGER
   ZINGIBER-OFFICINALE; TYPE-2 DIABETES-MELLITUS; GRAECUM FENUGREEK SEEDS;
   INDUCED LIVER-DAMAGE; CINNAMON EXTRACT; IMPROVES GLUCOSE; OXIDATIVE
   STRESS
AB Metabolic syndrome (MetS) therapy with phytochemicals is an emerging field of study with therapeutic potential. Obesity, insulin resistance, high blood pressure, and abnormal lipid profiles are all components of metabolic syndrome, which is a major public health concern across the world. New research highlights the promise of phytochemicals found in foods, including fruits, vegetables, herbs, and spices, as a sustainable and innovative method of treating this illness. Anti-inflammatory, antioxidant, and insulin-sensitizing qualities are just a few of the many positive impacts shown by bioactive substances. Collectively, they alleviate the hallmark symptoms of metabolic syndrome by modulating critical metabolic pathways, boosting insulin sensitivity, decreasing oxidative stress, and calming chronic low-grade inflammation. In addition, phytochemicals provide a multimodal strategy by targeting not only adipose tissue but also the liver, skeletal muscle, and vascular endothelium, all of which have a role in the pathogenesis of MetS. Increasing evidence suggests that these natural chemicals may be useful in controlling metabolic syndrome as a complementary treatment to standard medication or lifestyle changes. This review article emphasizes the therapeutic potential of phytochemicals, illuminating their varied modes of action and their ability to alleviate the interconnected causes of metabolic syndrome. Phytochemical-based interventions show promise as a novel and sustainable approach to combating the rising global burden of metabolic syndrome, with the ultimate goal of bettering public health and quality of life.
C1 [Gauttam, Vinod Kumar] Shiva Inst Pharm, Dept Pharmacognosy, Bilaspur, Himachal Prades, India.
   [Munjal, Kavita] Amity Univ, Amity Inst Pharm, Dept Pharmacognosy, Noida, Uttar Pradesh, India.
   [Chopra, Hitesh] Saveetha Inst Med & Tech Sci, Saveetha Sch Engn, Dept Biosci, Chennai 602105, Tamil Nadu, India.
   [Ahmad, Aftab] King Abdulaziz Univ, Dept Pharmacol, Jeddah, Saudi Arabia.
   [Rana, Mahesh Kumar] MM Deemed Be Univ, Dept Agr, Ambala 133207, Haryana, India.
   [Kamal, Mohammad Amjad] Sichuan Univ, West China Hosp, Frontiers Sci Ctr Dis Related Mol Network, Inst Syst Genet, Chengdu, Peoples R China.
   [Kamal, Mohammad Amjad] King Abdulaziz Univ, King Fahd Med Res Ctr, Jeddah 21589, Saudi Arabia.
   [Kamal, Mohammad Amjad] Daffodil Int Univ, Fac Allied Hlth Sci, Dept Pharm, Dhaka 1207, Bangladesh.
   [Kamal, Mohammad Amjad] Enzymoics, 7 Peterlee Pl, Hebersham, NSW 2770, Australia.
   [Kamal, Mohammad Amjad] Novel Global Community Educ Fdn, Hebersham, NSW 2770, Australia.
C3 Amity University Noida; Saveetha Institute of Medical & Technical
   Science; Saveetha School of Engineering; King Abdulaziz University;
   Sichuan University; King Abdulaziz University; Daffodil International
   University
RP Munjal, K (corresponding author), Amity Univ, Amity Inst Pharm, Dept Pharmacognosy, Noida, Uttar Pradesh, India.; Kamal, MA (corresponding author), Sichuan Univ, West China Hosp, Frontiers Sci Ctr Dis Related Mol Network, Inst Syst Genet, Chengdu, Peoples R China.; Kamal, MA (corresponding author), King Abdulaziz Univ, King Fahd Med Res Ctr, Jeddah 21589, Saudi Arabia.; Kamal, MA (corresponding author), Daffodil Int Univ, Fac Allied Hlth Sci, Dept Pharm, Dhaka 1207, Bangladesh.; Kamal, MA (corresponding author), Enzymoics, 7 Peterlee Pl, Hebersham, NSW 2770, Australia.; Kamal, MA (corresponding author), Novel Global Community Educ Fdn, Hebersham, NSW 2770, Australia.
EM kavitamunjal915@gmail.com; rrs.usa.au@gmail.com
RI Chopra, Hitesh/AAA-6925-2021; Gauttam, Vinod/AAA-8784-2022; Munjal,
   Kavita/ABF-9631-2020; AHMAD, AFTAB/J-2910-2012; Kamal, Mohammad
   Amjad/J-2918-2014
OI CHOPRA, HITESH/0000-0001-8867-7603; Kamal, Mohammad
   Amjad/0000-0003-0088-0565
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NR 266
TC 0
Z9 0
U1 4
U2 8
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1381-6128
EI 1873-4286
J9 CURR PHARM DESIGN
JI Curr. Pharm. Design
PY 2024
VL 30
IS 1
BP 10
EP 30
DI 10.2174/0113816128274446231220113957
PG 21
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA KA8S6
UT WOS:001177337800003
PM 38155468
DA 2025-06-11
ER

PT J
AU Xie, YD
   Liu, JP
   Wang, W
   Shi, YH
   Wang, XP
   Sun, M
   Xu, XY
   Li, N
AF Xie, Yun-Dong
   Liu, Ji-Ping
   Wang, Wei
   Shi, Yong-Heng
   Wang, Xiao-Ping
   Sun, Meng
   Xu, Xin-Ya
   Li, Na
TI 3,4-Dihydroxyphenethyl nitrate with nitric oxide releasing, antioxidant,
   hypoglycemic and hypolipidemic effects
SO BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
LA English
DT Article
ID ENDOTHELIAL DYSFUNCTION; METABOLIC SYNDROME; OXIDATIVE STRESS;
   HYDROXYTYROSOL; MECHANISMS
C1 [Xie, Yun-Dong; Liu, Ji-Ping; Wang, Wei; Shi, Yong-Heng; Wang, Xiao-Ping; Sun, Meng; Xu, Xin-Ya; Li, Na] Shaanxi Univ Chinese Med, Coll Pharm, Shiji Ave, Xian 712046, Shaanxi, Peoples R China.
   [Xie, Yun-Dong; Liu, Ji-Ping; Shi, Yong-Heng; Xu, Xin-Ya] Shaanxi Adm Tradit Chinese Med, Key Lab Pharmacodynam & Mat Basis Chinese Med, Xianyang 712046, Peoples R China.
C3 Shaanxi University of Chinese Medicine
RP Xie, YD (corresponding author), Shaanxi Univ Chinese Med, Coll Pharm, Shiji Ave, Xian 712046, Shaanxi, Peoples R China.
EM eng522@126.com
RI Wang, Xiaoping/IXW-5418-2023; Xie, Yundong/MVX-4149-2025; liu,
   jiping/MTA-6852-2025
OI Xu, Xinya/0000-0002-3250-4399
FU Key Laboratory of Pharmacodynamics and Material Basis of Chinese
   Medicine, Shaanxi Administration of Traditional Chinese Medicine;
   Shaanxi University of Chinese Medicine
FX Key Laboratory of Pharmacodynamics and Material Basis of Chinese
   Medicine, Shaanxi Administration of Traditional Chinese Medicine is
   gratefully acknowledged. Thanks for providing the experimental platform
   so that the experiment can be completed smoothly. Thanks for the
   start-up fund for doctoral scientific research given by Shaanxi
   University of Chinese Medicine.
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NR 24
TC 2
Z9 3
U1 1
U2 12
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0960-894X
EI 1464-3405
J9 BIOORG MED CHEM LETT
JI Bioorg. Med. Chem. Lett.
PD AUG 1
PY 2020
VL 30
IS 15
AR 127277
DI 10.1016/j.bmcl.2020.127277
PG 5
WC Chemistry, Medicinal; Chemistry, Organic
WE Science Citation Index Expanded (SCI-EXPANDED); Index Chemicus (IC)
SC Pharmacology & Pharmacy; Chemistry
GA LX7CS
UT WOS:000539985900011
PM 32527456
DA 2025-06-11
ER

PT J
AU Liu, ZS
AF Liu, Zaisheng
TI Efficacy of metformin combined with liraglutide on the glucose and lipid
   metabolism, vascular endothelial function, and oxidative stress of
   patients with T2DM and metabolic syndrome
SO PAKISTAN JOURNAL OF MEDICAL SCIENCES
LA English
DT Article
DE Glucose and lipid metabolism; Oxidative stress Liraglutide; Metformin;
   Metabolic syndrome; Type-2 diabetes; Vascular endothelial function
ID GLYCEMIC CONTROL
AB Objective: This study evaluates the impact of metformin combined with liraglutide on the glucose and lipid metabolism, oxidative stress, and vascular endothelium of patients with type-2 diabetes mellitus (T2DM) and metabolic syndrome. Methods: Medical records of 78 patients with T2DM and metabolic syndrome, admitted to Caoxian People's Hospital from July 2021 to July 2022, were retrospectively analysed. Thirty five patients were treated with metformin (control group), and 43 patients were treated with metformin combined with liraglutide (observation group). Indexes of glucose and lipid metabolism, function of vascular endothelium and the oxidative stress of both groups were compared before and after the treatment. Results: There was a significant decrease in the levels of fasting plasma glucose (FPG), Glycosylated Hemoglobin A1c (HbA1c), triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), systolic blood pressure (SBP), diastolic blood pressure (DBP) and waist circumference in both groups three months after the treatment, These indexes were significantly lower in the observation group compared to the control group (P<0.05). High -density lipoprotein cholesterol (HDL-C) levels were higher in the observation group (P<0.05). There was a significant improvement in the levels of nitric oxide (NO), endothelin-1 (ET-1), superoxide dismutase (SOD), and malondialdehyde (MDA) after the treatment, and these indexes were markedly better in the observation group compared to the control group (P<0.05). Conclusions: Metformin combined with liraglutide treatment is associated with better outcomes than metformin alone in patients with T2DM and metabolic syndrome. Combined treatment results in improved glucose and lipid metabolism, vascular endothelial function, and oxidative stress index values.
C1 [Liu, Zaisheng] Caoxian Peoples Hosp, Dept Endocrinol, Heze 274400, Shandong, Peoples R China.
RP Liu, ZS (corresponding author), Caoxian Peoples Hosp, Dept Endocrinol, Heze 274400, Shandong, Peoples R China.
EM liuzaishengcx@126.com
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NR 25
TC 4
Z9 4
U1 3
U2 3
PU PROFESSIONAL MEDICAL PUBLICATIONS
PI SADDAR
PA PANORAMA CENTRE, RM 522, 5TH FLOOR, BLDG 2, RAJA GHAZANFAR ALI RD, PO
   BOX 8766, SADDAR, KARACHI 00000, PAKISTAN
SN 1682-024X
EI 1681-715X
J9 PAK J MED SCI
JI Pak. J. Med. Sci.
PD JAN-FEB
PY 2024
VL 40
IS 1
BP 26
EP 30
DI 10.12669/pjms.40.1.7936
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA IK1L9
UT WOS:001166126600026
PM 38196473
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Giglio, RV
   Nikolic, D
   Li Volti, G
   Stoian, AP
   Banerjee, Y
   Magan-Fernandez, A
   Castellino, G
   Patti, AM
   Chianetta, R
   Castracani, CC
   Montalto, G
   Rizvi, AA
   Sesti, G
   Rizzo, M
AF Giglio, Rosaria Vincenza
   Nikolic, Dragana
   Li Volti, Giovanni
   Stoian, Anca Pantea
   Banerjee, Yajnavalka
   Magan-Fernandez, Antonio
   Castellino, Giuseppa
   Patti, Angelo Maria
   Chianetta, Roberta
   Castracani, Carlo Castruccio
   Montalto, Giuseppe
   Rizvi, Ali A.
   Sesti, Giorgio
   Rizzo, Manfredi
TI Liraglutide Increases Serum Levels of MicroRNA-27b, -130a and -210 in
   Patients with Type 2 Diabetes Mellitus: A Novel Epigenetic Effect
SO METABOLITES
LA English
DT Article
DE liraglutide; microRNAs; type-2 diabetes; cardiometabolic risk;
   epigenetic
ID INTIMA-MEDIA THICKNESS; INCRETIN-BASED THERAPIES; METABOLIC SYNDROME;
   CARDIOVASCULAR-DISEASE; OXIDATIVE STRESS; PEPTIDE-1 GLP-1; EXPRESSION;
   TARGETS; MANAGEMENT; INFLAMMATION
AB Liraglutide has shown favourable effects on several cardiometabolic risk factors, beyond glucose control. MicroRNAs (miRNAs) regulate gene expression, resulting in post-transcriptional modifications of cell response and function. Specific miRNAs, including miRNA-27b, miRNA-130a, and miRNA-210, play a role in cardiometabolic disease. We aimed to determine the effect of liraglutide on the serum levels of miRNA-27b, miRNA-130a and miRNA-210. Twenty-five subjects with type-2 diabetes mellitus (T2DM), naive to incretin-based therapy, were treated with liraglutide (1.2 mg/day as an add-on to metformin) for 4 months. miRNAs were quantified using real-time polymerase chain reaction. After liraglutide treatment, we found significant reductions in fasting glucose (from 9.8 +/- 5.3 to 6.7 +/- 1.6 mmol/L, p = 0.0042), glycosylated haemoglobin (HbA1c) (from 8.1 +/- 0.8 to 6.6 +/- 1.0%, p = 0.0008), total cholesterol (from 5.0 +/- 1.0 to 4.0 +/- 0.7 mmol/L, p = 0.0011), triglycerides (from 1.9 +/- 1.0 to 1.5 +/- 0.8 mmol/L, p = 0.0104) and low-density lipoprotein cholesterol (from 2.9 +/- 1.2 to 2.2 +/- 0.6 mmol/L, p = 0.0125), while the serum levels of miRNA-27b, miRNA-130a and miRNA-210a were significantly increased (median (interquartile range, IQR) changes: 1.73 (7.12) (p = 0.0401), 1.91 (3.64) (p = 0.0401) and 2.09 (11.0) (p = 0.0486), respectively). Since the changes in miRNAs were independent of changes in all the metabolic parameters investigated, liraglutide seems to exert a direct epigenetic effect in T2DM patients, regulating microRNAs involved in the maintenance of endothelial cell homeostasis. These changes might be implicated in liraglutide's benefits and may represent useful targets for cardiometabolic management.
C1 [Giglio, Rosaria Vincenza; Nikolic, Dragana; Magan-Fernandez, Antonio; Castellino, Giuseppa; Patti, Angelo Maria; Chianetta, Roberta; Montalto, Giuseppe; Rizzo, Manfredi] Univ Palermo, Dept Hlth Promot Sci Maternal & Infantile Care, Internal Med & Med Specialties PROMISE, I-90127 Palermo, Italy.
   [Li Volti, Giovanni; Castracani, Carlo Castruccio] Univ Catania, Dept Biomed & Biotechnol Sci, I-95125 Catania, Italy.
   [Stoian, Anca Pantea] Carol Davila Univ Med & Pharm, Dept Diabet Nutr & Metab Dis, Bucharest 050474, Romania.
   [Banerjee, Yajnavalka] Mohammed Bin Rashid Univ Med & Hlth Sci, Coll Med, Dubai, U Arab Emirates.
   [Rizvi, Ali A.; Rizzo, Manfredi] Univ South Carolina, Div End Sch Medocrinol Diabet & Metab, Columbia, SC 29203 USA.
   [Rizvi, Ali A.] Emory Univ, Sch Med, Div Endocrinol Metab & Lipids, Atlanta, GA 30322 USA.
   [Sesti, Giorgio] Univ Roma La Sapienza, Dept Clin & Mol Med, I-00182 Rome, Italy.
C3 University of Palermo; University of Catania; Carol Davila University of
   Medicine & Pharmacy; University of South Carolina System; University of
   South Carolina Columbia; Emory University; Sapienza University Rome
RP Rizvi, AA (corresponding author), Univ South Carolina, Div End Sch Medocrinol Diabet & Metab, Columbia, SC 29203 USA.; Rizvi, AA (corresponding author), Emory Univ, Sch Med, Div Endocrinol Metab & Lipids, Atlanta, GA 30322 USA.
EM rosaria.vincenza.giglio@alice.it; dragana.nikolic@unipa.it;
   livolti@unict.it; ancastoian@yahoo.com; Yajnavalka.Banerjee@mbru.ac.ae;
   amaganf@ugr.es; castellinogiusy@gmail.com; pattiangelomaria@gmail.com;
   chianetta.roberta8@gmail.com; carlo.castruccio@unict.it;
   giuseppe.montalto@unipa.it; arizvi4@emory.edu;
   giorgio.sesti@uniroma1.it; manfredi.rizzo@unipa.it
RI Licata, Anna/ADF-0000-2022; RIZZO, MANFREDI/GZL-0551-2022; Rizvi,
   Ali/AFV-2240-2022; Volti, Giovanni/A-2435-2008; Sesti,
   Giorgio/B-1509-2012; Castellino, Giuseppa/AAF-4272-2020; Banerjee,
   Yajnavalka/J-5890-2019; Castruccio Castracani, Carlo/HTN-2949-2023;
   GIGLIO, Rosaria Vincenza/IAR-9444-2023; Magan-Fernandez,
   Antonio/C-1047-2014; Castruccio Castracani, Carlo/U-5710-2018; Pantea
   Stoian, Anca/H-5799-2017
OI Nikolic, Dragana/0000-0001-9572-9651; Li Volti,
   Giovanni/0000-0002-8678-2183; Banerjee, Yajnavalka/0000-0002-7546-8893;
   Magan-Fernandez, Antonio/0000-0001-6430-2276; Castruccio Castracani,
   Carlo/0000-0002-1002-8969; Chianetta, Roberta/0009-0001-3855-0206;
   Pantea Stoian, Anca/0000-0003-0555-526X; GIGLIO, Rosaria
   Vincenza/0000-0002-7968-1480; RIZZO, Manfredi/0000-0002-9549-8504
FU University of Granada, under the FPU research fellowship program
   (Ministry of Education and Science, Spain)
FX We want to thank all the volunteers who participated in this study.
   A.M.F. participated in this study through an International PhD programme
   in collaboration with the University of Granada, under the FPU research
   fellowship program (Ministry of Education and Science, Spain). The
   authors wish to thank Francisco Mesa from the University of Granada for
   valuable scientific support during the study.
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NR 85
TC 17
Z9 17
U1 0
U2 7
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2218-1989
J9 METABOLITES
JI Metabolites
PD OCT
PY 2020
VL 10
IS 10
AR 391
DI 10.3390/metabo10100391
PG 14
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA ON7WQ
UT WOS:000586906500001
PM 33008044
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Godin, O
   Pignon, B
   Szoke, A
   Boyer, L
   Aouizerate, B
   Schorr, B
   Andre, M
   Capdevielle, D
   Chereau, I
   Coulon, N
   Dassing, R
   Dubertret, C
   Etain, B
   Leignier, S
   Llorca, PM
   Mallet, J
   Misdrahi, D
   Passerieux, C
   Rey, R
   Urbach, M
   Schuerhoff, F
   Leboyer, M
   Fond, G
AF Godin, O.
   Pignon, B.
   Szoke, A.
   Boyer, L.
   Aouizerate, B.
   Schorr, B.
   Andre, M.
   Capdevielle, D.
   Chereau, I.
   Coulon, N.
   Dassing, R.
   Dubertret, C.
   Etain, B.
   Leignier, S.
   Llorca, P. M.
   Mallet, J.
   Misdrahi, D.
   Passerieux, C.
   Rey, R.
   Urbach, M.
   Schuerhoff, F.
   Leboyer, M.
   Fond, G.
TI 3-year incidence and predictors of metabolic syndrome in schizophrenia
   in the national FACE-SZ cohort
SO PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
LA English
DT Article
DE Mental health; Psychiatry schizophrenia; Depressive disorders;
   Depression; Metabolic syndrome
ID MAJOR DEPRESSIVE DISORDER; CARDIOVASCULAR-DISEASE; BIPOLAR DISORDER;
   WEIGHT-GAIN; MENTAL-ILLNESS; RISK; METAANALYSIS; PREVALENCE; MORTALITY;
   SMOKING
AB Aims: Metabolic Syndrome (MetS) is a major health epidemic of Western countries and patients with schizo-phrenia is a particularly vulnerable population due to lifestyle, mental illness and treatment factors. However, we lack prospective data to guide prevention. The aim of our study is then to determine MetS incidence and pre-dictors in schizophrenia. Method: Participants were recruited in 10 expert centers at a national level and followed-up for 3 years. MetS was defined according to the International Diabetes Federation criteria. Inverse probability weighting methods were used to correct for attrition bias. Results: Among the 512 participants followed-up for 3 years, 77.9% had at least one metabolic disturbance. 27.5% were identified with MetS at baseline and excluded from the analyses. Among the rest of participants (N = 371, mean aged 31.2 (SD = 9.1) years, with mean illness duration of 10.0 (SD = 7.6) years and 273 (73.6%) men), MetS incidence was 20.8% at 3 years and raised to 23.6% in tobacco smokers, 29.4% in participants receiving antidepressant prescription at baseline and 42.0% for those with 2 disturbed metabolic disturbances at baseline. Our multivariate analyses confirmed tobacco smoking and antidepressant consumption as independent predictors of MetS onset (adjusted odds ratios (aOR) = 3.82 [1.27-11.45], p = 0.016, and aOR = 3.50 [1.26-9.70], p = 0.0158). Antidepressant prescription predicted more specifically increased lipid disturbances and paroxetine was associated with the highest risk of MetS onset. Conclusion: These results are an alarm call to prioritize MetS prevention and research in schizophrenia. We have listed interventions that should be actively promoted in clinical practice.
C1 [Godin, O.; Pignon, B.; Szoke, A.; Boyer, L.; Aouizerate, B.; Schorr, B.; Andre, M.; Capdevielle, D.; Chereau, I.; Coulon, N.; Dassing, R.; Dubertret, C.; Etain, B.; Leignier, S.; Llorca, P. M.; Mallet, J.; Misdrahi, D.; Passerieux, C.; Rey, R.; Urbach, M.; Schuerhoff, F.; Leboyer, M.; Fond, G.] Fdn FondaMental, Creteil, France.
   [Godin, O.; Pignon, B.; Szoke, A.; Schuerhoff, F.; Leboyer, M.] Univ Paris Est Creteil, Hop Univ Mondor H, Dept Hosp Univ Psychiat & Addictol, INSERM U955,AP HP, Creteil, France.
   [Andre, M.; Capdevielle, D.] Univ Montpellier I, Hop Colombiere, Serv Univ Psychiat Adulte, CHRU Montpellier, F-1061 Montpellier, France.
   [Aouizerate, B.] Univ Bordeaux, Ctr Hosp Charles Perrens, F-33076 Bordeaux, France.
   [Aouizerate, B.] Univ Bordeaux, INRAE, NutriNeuro, U1286, F-33076 Bordeaux, France.
   [Schorr, B.; Dassing, R.] Univ Strasbourg, Hop Univ Strasbourg, INSERM U1114, Federat Med Translat Strasbourg, Strasbourg, France.
   [Chereau, I.; Llorca, P. M.] Univ Clermont Auvergne, Dept Psychiat, CHU Clermont Ferrand, Clermont Ferrand, France.
   [Coulon, N.; Leignier, S.] CH Alpes Isere, Ctr Referent Rehabil Psychosociale, Grenoble, France.
   [Rey, R.] Univ Claude Bernard Lyon 1, Ctr Rech Neurosci Lyon, Ctr Hosp Vinatier, Equipe PSYR2,INSERM,U1028,CNRS,UMR5292, 95 bd Pinel, BP 30039, F-69678 Bron, France.
   [Dubertret, C.; Mallet, J.] Univ Paris, Hop Louis Mourier, Serv Psychiat & Addictol, INSERM UMR1266, Colombes, France.
   [Etain, B.] Univ Paris, AP HP, Dept Psychiat & Medecine Addictol, GHU St Louis Lariboisiere Fernand Widal, Paris, France.
   [Fond, G.] Aix Marseille Univ, Qual Life Ctr, Sch Med, La Timone,Med Campus,Hlth Serv Res, 27 Blvd Jean Moulin, F-13005 Marseille, France.
   [Misdrahi, D.] Charles Perrens Hosp, Dept Adult Psychiat, Bordeaux, France.
   [Misdrahi, D.] Univ Bordeaux, CNRS UMR 5287 INCIA Neuroimagerie & Cognit Humaine, Bordeaux, France.
   [Passerieux, C.; Urbach, M.] Univ Versailles St Quentin en Yvelines, Serv Univ Psychiat & Addictol, Ctr Hosp Versailles, Team DevPsy,INSERM UMR1018,CESP, Paris, France.
C3 Universite Paris-Est-Creteil-Val-de-Marne (UPEC); Assistance Publique
   Hopitaux Paris (APHP); Hopital Universitaire Henri-Mondor - APHP;
   Institut National de la Sante et de la Recherche Medicale (Inserm);
   Universite de Montpellier; CHU de Montpellier; Universite de Bordeaux;
   Universite de Bordeaux; INRAE; Institut National de la Sante et de la
   Recherche Medicale (Inserm); CHU Strasbourg; Universites de Strasbourg
   Etablissements Associes; Universite de Strasbourg; Institut National de
   la Sante et de la Recherche Medicale (Inserm); Universite Clermont
   Auvergne (UCA); CHU Clermont Ferrand; Centre National de la Recherche
   Scientifique (CNRS); Institut National de la Sante et de la Recherche
   Medicale (Inserm); Universite Claude Bernard Lyon 1; Universite Jean
   Monnet; CNRS - National Institute for Biology (INSB); Assistance
   Publique Hopitaux Paris (APHP); Universite Paris Cite; Hopital
   Universitaire Louis-Mourier - APHP; Institut National de la Sante et de
   la Recherche Medicale (Inserm); Assistance Publique Hopitaux Paris
   (APHP); Universite Paris Cite; Hopital Universitaire Saint-Louis - APHP;
   Hopital Universitaire Lariboisiere-Fernand-Widal - APHP; Aix-Marseille
   Universite; Assistance Publique-Hopitaux de Marseille; Universite de
   Bordeaux; Centre Hospitalier de Versailles; Universite Paris Saclay;
   Institut National de la Sante et de la Recherche Medicale (Inserm)
RP Fond, G (corresponding author), Fdn FondaMental, Creteil, France.
EM guillaume.fond@gmail.com
RI Fond, Guillaume/D-7646-2011; COULON, Nathalie/HLW-3075-2023; BOYER,
   Laurent/AAH-4543-2021; Capdevielle, Delphine/HTO-4229-2023; Mallet,
   Jasmina/GNP-7160-2022; Boyer, Laurent/E-5728-2016
OI Aouizerate, Bruno/0000-0002-7092-7747; COULON,
   Nathalie/0000-0001-7765-1117; Boyer, Laurent/0000-0003-1229-6622
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NR 70
TC 6
Z9 6
U1 2
U2 15
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0278-5846
EI 1878-4216
J9 PROG NEURO-PSYCHOPH
JI Prog. Neuro-Psychopharmacol. Biol. Psychiatry
PD JAN 10
PY 2023
VL 120
AR 110641
DI 10.1016/j.pnpbp.2022.110641
EA OCT 2022
PG 10
WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA 6I1AA
UT WOS:000885857500002
PM 36122839
OA Bronze
DA 2025-06-11
ER

PT J
AU Tremblay, BL
   Guénard, F
   Lamarche, B
   Pérusse, L
   Vohl, MC
AF Tremblay, Benedicte L.
   Guenard, Frederic
   Lamarche, Benoit
   Perusse, Louis
   Vohl, Marie-Claude
TI Genetic and Common Environmental Contributions to Familial Resemblances
   in Plasma Carotenoid Concentrations in Healthy Families
SO NUTRIENTS
LA English
DT Article
DE -cryptoxanthin; bivariate analysis; cardiometabolic risk factors;
   carotenoids; familial resemblances; French Canadians; heritability;
   lutein; lycopene
ID C-REACTIVE PROTEIN; VEGETABLE INTAKE; RISK-FACTORS;
   CARDIOVASCULAR-DISEASE; LYCOPENE METABOLISM; DIETARY ASSESSMENT; SERUM
   CAROTENOIDS; OXIDATIVE STRESS; FRUIT; BIOMARKERS
AB Carotenoids have shown an interindividual variability that may be due to genetic factors. The only study that has reported heritability of serum - and -carotene has not considered the environmental component. This study aimed to estimate the contribution of both genetic and common environmental effects to the variance of carotenoid concentrations and to test whether their phenotypic correlations with cardiometabolic risk factors are explained by shared genetic and environmental effects. Plasma carotenoid concentrations (-carotene, -carotene, -cryptoxanthin, lutein, lycopene, zeaxanthin, and total carotenoids) of 48 healthy subjects were measured. Heritability estimates of carotenoid concentrations were calculated using the variance component method. Lutein and lycopene showed a significant familial effect (p = 6 x 10(-6) and 0.0043, respectively). Maximal heritability, genetic heritability, and common environmental effect were computed for lutein (88.3%, 43.8%, and 44.5%, respectively) and lycopene (45.2%, 0%, and 45.2%, respectively). Significant phenotypic correlations between carotenoid concentrations and cardiometabolic risk factors were obtained for -cryptoxanthin, lycopene, and zeaxanthin. Familial resemblances in lycopene concentrations were mainly attributable to common environmental effects, while for lutein concentrations they were attributable to genetic and common environmental effects. Common genetic and environmental factors may influence carotenoids and cardiometabolic risk factors, but further studies are needed to better understand the potential impact on disease development.
C1 [Tremblay, Benedicte L.; Guenard, Frederic; Lamarche, Benoit; Perusse, Louis; Vohl, Marie-Claude] Laval Univ, Inst Nutr & Funct Foods INAF, 2440 Hochelaga Blvd, Quebec City, PQ G1V 0A6, Canada.
C3 Laval University
RP Vohl, MC (corresponding author), Laval Univ, Inst Nutr & Funct Foods INAF, 2440 Hochelaga Blvd, Quebec City, PQ G1V 0A6, Canada.
EM benedicte-l.tremblay.1@ulaval.ca; frederic.guenard@fsaa.ulaval.ca;
   benoit.lamarche@fsaa.ulaval.ca; louis.perusse@kin.ulaval.ca;
   marie-claude.vohl@fsaa.ulaval.ca
RI Vohl, Marie-Claude/AAQ-1378-2021; Lamarche, Benoit/ABA-4785-2021;
   Perusse, Louis/A-3444-2012
OI Vohl, Marie-Claude/0000-0002-7017-5848; Tremblay, Benedicte
   L/0009-0003-3546-020X; Lamarche, Benoit/0000-0002-4443-5378; Perusse,
   Louis/0000-0001-6440-9698
FU Canada Research Chair in Genomics Applied to Nutrition and Metabolic
   Health
FX This work was supported by the Canada Research Chair in Genomics Applied
   to Nutrition and Metabolic Health.
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NR 72
TC 7
Z9 7
U1 0
U2 2
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD AUG
PY 2018
VL 10
IS 8
AR 1002
DI 10.3390/nu10081002
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA GU9PD
UT WOS:000445680200050
PM 30065157
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Lally, J
   Gardner-Sood, P
   Firdosi, M
   Iyegbe, C
   Stubbs, B
   Greenwood, K
   Murray, R
   Smith, S
   Howes, O
   Gaughran, F
AF Lally, J.
   Gardner-Sood, P.
   Firdosi, M.
   Iyegbe, C.
   Stubbs, B.
   Greenwood, K.
   Murray, R.
   Smith, S.
   Howes, O.
   Gaughran, F.
TI Clinical correlates of vitamin D deficiency in established psychosis
SO BMC PSYCHIATRY
LA English
DT Article
DE Schizophrenia; Psychosis; Vitamin D; Metabolic syndrome; Cardiovascular
ID TYPE-2 DIABETES-MELLITUS; BONE-MINERAL DENSITY; CARDIOVASCULAR-DISEASE;
   SCHIZOPHRENIA; RISK; PREVALENCE; DEPRESSION; DISORDERS; MORTALITY;
   PEOPLE
AB Background: Suboptimal vitamin D levels have been identified in populations with psychotic disorders. We sought to explore the relationship between vitamin D deficiency, clinical characteristics and cardiovascular disease risk factors among people with established psychosis.
   Methods: Vitamin D levels were measured in 324 community dwelling individuals in England with established psychotic disorders, along with measures of mental health, cardiovascular risk and lifestyle choices. Vitamin D deficiency was defined as serum 25-hydroxyvitamin D (25-OHD) levels below 10 ng/ml (equivalent to < 25 nmol/L) and "sufficient" Vitamin D as above 30 ng/ml (> 50 nmol/L).
   Results: The mean 25-OHD serum level was 12.4 (SD 7.3) ng/ml, (range 4.0-51.7 ng/ml). Forty nine percent (n = 158) were vitamin D deficient, with only 14 % (n = 45) meeting criteria for sufficiency. Accounting for age, gender, ethnicity and season of sampling, serum 25-OHD levels were negatively correlated with waist circumference (r = -0.220, p < 0.002), triglycerides (r = -0.160, p = 0.024), total cholesterol (r = -0.144, p = 0.043), fasting glucose (r = -0.191, p = 0.007), HbA1c (r = -0.183, p = 0.01), and serum CRP levels (r = -0.211, p = 0.003) and were linked to the presence of metabolic syndrome.
   Conclusions: This is the largest cross sectional study of serum 25-OHD levels in community dwelling individuals with established psychosis, indicating a high level of vitamin D deficiency. Lower vitamin D levels are associated with increased cardiovascular disease risk factors and in particular metabolic syndrome. Further research is needed to define appropriate protocols for vitamin D testing and supplementation in practice to see if this can improve cardiovascular disease risk.
C1 [Lally, J.; Gardner-Sood, P.; Iyegbe, C.; Howes, O.; Gaughran, F.] Kings Coll London, Inst Psychiat Psychol & Neurosci IoPPN, Dept Psychosis Studies, London SE5 8AF, England.
   [Lally, J.; Gaughran, F.] South London & Maudsley NHS Fdn Trust, Natl Psychosis Serv, London, England.
   [Firdosi, M.] South London & Maudsley NHS Fdn Trust, London, England.
   [Stubbs, B.] Kings Coll London, Inst Psychiat Psychol & Neurosci, Hlth Serv & Populat Res Dept, London SE5 8AF, England.
   [Stubbs, B.] South London & Maudsley NHS Fdn Trust, Physiotherapy Dept, London, England.
   [Greenwood, K.] Univ Sussex, Brighton & Early Intervent Psychosis Serv, Sch Psychol, Sussex Partnership NHS Fdn Trust, Brighton, W Sussex, England.
   [Murray, R.; Smith, S.] Kings Coll London, Inst Psychiat Psychol & Neurosci IoPPN, London SE5 8AF, England.
   [Howes, O.] Univ London Imperial Coll Sci Technol & Med, MRC, Ctr Clin Sci, Dept Psychosis Studies, Hammersmith Hosp Campus, London W12 0NN, England.
C3 University of London; King's College London; South London & Maudsley NHS
   Trust; South London & Maudsley NHS Trust; University of London; King's
   College London; South London & Maudsley NHS Trust; University of Sussex;
   University of London; King's College London; Imperial College London
RP Gaughran, F (corresponding author), Kings Coll London, Inst Psychiat Psychol & Neurosci IoPPN, Dept Psychosis Studies, London SE5 8AF, England.; Gaughran, F (corresponding author), South London & Maudsley NHS Fdn Trust, Natl Psychosis Serv, London, England.
EM Fiona.p.gaughran@kcl.ac.uk
RI Gaughran, Fiona/AAC-7160-2019; Howes, Oliver/E-7156-2010; Stubbs,
   Brendon/X-1904-2018; greenwood, kathryn/I-8638-2012; Gaughran,
   Fiona/H-5495-2011; Stubbs, Brendon/C-5696-2015; Firdosi,
   Muhammad/P-7974-2019; murray, robin/F-8658-2012
OI Smith, Shubulade/0000-0002-3797-6985; Greenwood,
   Kathryn/0000-0001-7899-8980; Gaughran, Fiona/0000-0001-7414-5569;
   Stubbs, Brendon/0000-0001-7387-3791; Firdosi,
   Muhammad/0000-0002-8450-6484; Lally, John/0000-0003-3038-0625; murray,
   robin/0000-0003-0829-0519
FU National Institute for Health Research (NIHR) under its IMPACT Programme
   [RP-PG-0606-1049]; Medical Research Council-UK [MC-A656-5QD30]; Maudsley
   Charity [666]; Brain and Behavior Research Foundation; Wellcome Trust
   [094849/Z/10/Z]; National Institute for Health Research (NIHR)
   Biomedical Research Centre at South London and Maudsley NHS Foundation
   Trust and King's College London; MRC [MC_U120097115, G0700995] Funding
   Source: UKRI
FX This paper summarises independent research funded by the National
   Institute for Health Research (NIHR) under its IMPACT Programme (Grant
   Reference Number RP-PG-0606-1049). This study was also partially funded
   by Medical Research Council-UK (no. MC-A656-5QD30), Maudsley Charity
   (no. 666), Brain and Behavior Research Foundation, and Wellcome Trust
   (no. 094849/Z/10/Z) grants to Dr Howes and the National Institute for
   Health Research (NIHR) Biomedical Research Centre at South London and
   Maudsley NHS Foundation Trust and King's College London. The views
   expressed are those of the author (s) and not necessarily those of the
   National Health Service (NHS), the NIHR or the Department of Health. We
   thank all the participants in this study for generously helping us in
   this research.
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NR 49
TC 47
Z9 50
U1 0
U2 14
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-244X
J9 BMC PSYCHIATRY
JI BMC Psychiatry
PD MAR 22
PY 2016
VL 16
AR 76
DI 10.1186/s12888-016-0780-2
PG 9
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychiatry
GA DH4FA
UT WOS:000372739700002
PM 27000113
OA Green Accepted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Hepgul, N
   Pariante, CM
   Dipasquale, S
   DiForti, M
   Taylor, H
   Marques, TR
   Morgan, C
   Dazzan, P
   Murray, RM
   Mondelli, V
AF Hepgul, N.
   Pariante, C. M.
   Dipasquale, S.
   DiForti, M.
   Taylor, H.
   Marques, T. R.
   Morgan, C.
   Dazzan, P.
   Murray, R. M.
   Mondelli, V.
TI Childhood maltreatment is associated with increased body mass index and
   increased C-reactive protein levels in first-episode psychosis patients
SO PSYCHOLOGICAL MEDICINE
LA English
DT Article
DE Body mass index; childhood maltreatment; inflammation; metabolic
   syndrome; psychosis
ID DRUG-NAIVE PATIENTS; HIPPOCAMPAL VOLUME; METABOLIC SYNDROME;
   CORTISOL-LEVELS; 1ST EPISODE; STRESS; SCHIZOPHRENIA; INFLAMMATION;
   ABUSE; LIFE
AB Background. The high incidence of the metabolic syndrome in patients with psychosis is mainly attributed to antipsychotic treatment. However, it is also possible that psychological stress plays a role, inducing a chronic inflammatory process that may predispose to the development of metabolic abnormalities. We investigated the association between childhood maltreatment and inflammatory and metabolic biomarkers in subjects with first-episode psychosis and healthy controls.
   Method. Body mass index (BMI), weight and waist circumference were measured in 95 first-episode psychosis patients and 97 healthy controls. Inflammatory and metabolic markers were measured in a subsample of 28 patients and 45 controls. In all the subjects we collected information on childhood maltreatment and recent stressors.
   Results. Patients with childhood maltreatment had higher BMI [25.0 (S.E. = 0.6) kg/m(2)] and C-reactive protein (CRP) levels [1.1 (S.E. = 0.6) mg/dl] when compared with healthy controls [23.4 (S.E. = 0.4) kg/m(2), p = 0.030 and 0.2 (S.E. = 0.1) mg/dl, p = 0.009, respectively]. In contrast, patients without childhood maltreatment were not significantly different from healthy controls for either BMI [24.7 (S.E. = 0.6) kg/m(2), p = 0.07] or CRP levels [0.5 (S.E. = 0.2) mg/dl, p = 0.25]. After controlling for the effect of BMI, the difference in CRP levels across the three groups remained significant (F-2,F-58 = 3.6, p = 0.035), suggesting that the increase in inflammation was not driven by an increase in adipose tissue.
   Conclusions. Childhood maltreatment is associated with higher BMI, and increased CRP levels, in patients with a first-episode psychosis. Further studies need to confirm the mechanisms underlying the putative causal relationship between childhood maltreatment and higher BMI, and whether this is indeed mediated by increased inflammation.
C1 [Mondelli, V.] Kings Coll London, Inst Psychiat,Dept Psychol Med, James Black Ctr,Sect Perinatal Psychiat & Stress, Ctr Cellular Basis Behav,SPI Lab, London SE5 9NU, England.
   [DiForti, M.; Taylor, H.; Marques, T. R.; Morgan, C.; Dazzan, P.; Murray, R. M.] Kings Coll London, Inst Psychiat, Dept Psychosis Studies, London SE5 9NU, England.
C3 University of London; King's College London; University of London;
   King's College London
RP Mondelli, V (corresponding author), Kings Coll London, Inst Psychiat,Dept Psychol Med, James Black Ctr,Sect Perinatal Psychiat & Stress, Ctr Cellular Basis Behav,SPI Lab, 125 Coldharbour Lane, London SE5 9NU, England.
EM valeria.mondelli@kcl.ac.uk
RI Mondelli, Valeria/K-8988-2016; Dazzan, Paola/E-6837-2010; Pariante,
   Carmine Maria/B-1297-2011; Reis Marques, Tiago/F-2489-2010; murray,
   robin/F-8658-2012; Morgan, Craig/B-2100-2010
OI Dazzan, Paola/0000-0002-8427-3617; Mondelli,
   Valeria/0000-0001-8690-6839; Pariante, Carmine
   Maria/0000-0002-9132-5091; Reis Marques, Tiago/0000-0003-0602-7661;
   murray, robin/0000-0003-0829-0519; Morgan, Craig/0000-0002-1386-2369
FU South London and Maudsley NHS Foundation Trust; Institute of Psychiatry
   NIHR (National Institute for Health Research) Biomedical Research Centre
   for Mental Health; NARSAD (National Alliance for Research on
   Schizophrenia and Depression) Young Investigator Award; University of
   London Central Research Fund; King's College London Translational
   Research Grant; BIAL Foundation; British Academy; UK Medical Research
   Council; Commission of European Communities 7th Framework Programme
   Collaborative Project Grant [22963]; Wellcome Trust [WT087417]; MRC
   [G108/603, MR/J002739/1] Funding Source: UKRI
FX This research has been supported by the South London and Maudsley NHS
   Foundation Trust and the Institute of Psychiatry NIHR (National
   Institute for Health Research) Biomedical Research Centre for Mental
   Health; a NARSAD (National Alliance for Research on Schizophrenia and
   Depression) Young Investigator Award, to V. M. (2007-2010); a grant from
   the University of London Central Research Fund to V. M.; a King's
   College London Translational Research Grant and a grant from the BIAL
   Foundation to P. D.; and grants from the British Academy, the UK Medical
   Research Council, and the Commission of European Communities 7th
   Framework Programme Collaborative Project Grant Agreement no. 22963
   (Mood Inflame), to C. M. P.; and a grant from the Wellcome Trust (grant
   no. WT087417) to P. D., C. M., C. M. P. and R. M. We thank Roy Sherwood
   and Tracy Dew (King's College Hospital, UK) for conducting the
   biochemistry assays.
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NR 40
TC 86
Z9 94
U1 0
U2 27
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
SN 0033-2917
EI 1469-8978
J9 PSYCHOL MED
JI Psychol. Med.
PD SEP
PY 2012
VL 42
IS 9
BP 1893
EP 1901
DI 10.1017/S0033291711002947
PG 9
WC Psychology, Clinical; Psychiatry; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA 984LE
UT WOS:000307190400011
PM 22260948
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Kaur, N
   Gare, SR
   Shen, JH
   Raja, R
   Fonseka, O
   Liu, W
AF Kaur, Namrita
   Gare, Sanskruti Ravindra
   Shen, Jiahan
   Raja, Rida
   Fonseka, Oveena
   Liu, Wei
TI Multi-organ FGF21-FGFR1 signaling in metabolic health and disease
SO FRONTIERS IN CARDIOVASCULAR MEDICINE
LA English
DT Review
DE diabetes mellitus; metabolic stress; multi-organ signaling; treatment;
   heart failure
ID GROWTH-FACTOR 21; INCREASES ENERGY-EXPENDITURE; ENDOPLASMIC-RETICULUM
   STRESS; IMPROVES INSULIN SENSITIVITY; FGF21 REGULATES METABOLISM;
   BETA-KLOTHO; FACTOR RECEPTOR; DIABETIC CARDIOMYOPATHY; ENHANCED
   EFFICACY; EXPRESSION
AB Metabolic syndrome is a chronic systemic disease that is particularly manifested by obesity, diabetes, and hypertension, affecting multiple organs. The increasing prevalence of metabolic syndrome poses a threat to public health due to its complications, such as liver dysfunction and cardiovascular disease. Impaired adipose tissue plasticity is another factor contributing to metabolic syndrome. Emerging evidence demonstrates that fibroblast growth factors (FGFs) are critical players in organ crosstalk via binding to specific FGF receptors (FGFRs) and their co-receptors. FGFRs activation modulates intracellular responses in various cell types under metabolic stress. FGF21, in particular is considered as the key regulator for mediating systemic metabolic effects by binding to receptors FGFR1, FGFR3, and FGFR4. The complex of FGFR1 and beta Klotho (beta-KL) facilitates endocrine and paracrine communication networks that physiologically regulate global metabolism. This review will discuss FGF21-mediated FGFR1/beta-KL signaling pathways in the liver, adipose, and cardiovascular systems, as well as how this signaling is involved in the interplay of these organs during the metabolic syndrome. Furthermore, the clinical implications and therapeutic strategies for preventing metabolic syndrome and its complications by targeting FGFR1/beta-KL are also discussed.
C1 [Kaur, Namrita; Gare, Sanskruti Ravindra; Shen, Jiahan; Raja, Rida; Fonseka, Oveena; Liu, Wei] Univ Manchester, Fac Biol Med & Hlth, Sch Med Sci, Div Cardiovasc Sci, Manchester, England.
C3 University of Manchester
RP Liu, W (corresponding author), Univ Manchester, Fac Biol Med & Hlth, Sch Med Sci, Div Cardiovasc Sci, Manchester, England.
EM wei.liu@manchester.ac.uk
RI Kaur, Namrita/LFR-7050-2024
OI Kaur, Namrita/0000-0001-6628-0592; Gare, Sanskruti/0009-0001-0586-7522;
   Shen, Jiahan/0000-0003-4365-9959; Liu, Wei/0000-0003-1592-6693; Fonseka,
   Oveena/0009-0009-9949-7689
FU British Heart Foundation;  [FS/15/16/31477];  [FS/18/73/33973]; 
   [PG/19/66/34600];  [FS/19/70/34650]
FX Funding This work was supported by grants FS/15/16/31477,
   FS/18/73/33973, PG/19/66/34600, and FS/19/70/34650 to WL from the
   British Heart Foundation.
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NR 98
TC 13
Z9 14
U1 0
U2 23
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2297-055X
J9 FRONT CARDIOVASC MED
JI Front. Cardiovasc. Med.
PD AUG 2
PY 2022
VL 9
AR 962561
DI 10.3389/fcvm.2022.962561
PG 8
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 3V4AS
UT WOS:000841606000001
PM 35983184
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Pulkki, L
   Keltikangas-Järvinen, L
   Ravaja, N
   Viikari, J
AF Pulkki, L
   Keltikangas-Järvinen, L
   Ravaja, N
   Viikari, J
TI Child-rearing attitudes and cardiovascular risk among children::
   Moderating influence of parental socioeconomic status
SO PREVENTIVE MEDICINE
LA English
DT Article
DE socioeconomic status; child-rearing; insulin resistance syndrome;
   coronary heart disease; stress
ID FOLLOW-UP; INSULIN-RESISTANCE; YOUNG-ADULTS; GENDER DIFFERENCES; ANGER
   EXPRESSION; CORONARY RISK; HEALTH; DISEASE; STRESS; ASSOCIATIONS
AB Background. We examined associations of parental socioeconomic status (SES) and hostile maternal child-rearing attitudes with the insulin resistance syndrome (IRS) precursors in children.
   Methods. The participants were 210 randomly selected healthy boys and girls who participated in the epidemiological Cardiovascular Risk in Young Finns study and who were 3, 6, and 9 years of age at the three study phases. Hostile maternal child-rearing attitudes were self-rated by the mothers. SES consisted of the years of education of the parents and family income. The IRS comprised serum insulin, high-density lipoprotein cholesterol, triglycerides, systolic blood pressure, and body mass index.
   Results. Among boys, low parental SES and strict maternal discipline were associated with heightened somatic risk. Among girls, parental SES moderated the association between maternal child-rearing attitudes and somatic risk so that belonging to a high-SES family seemed to protect the girls against the adverse health effects of hostile mothering.
   Conclusions. The findings indicate that the psychosocial environment is differentially related to girls' and boys' somatic risk. It is concluded that belonging to high social class may buffer against childhood stress, while belonging to low social class may enhance vulnerability to stressors in childhood. (C) 2002 American Health Foundation and Elsevier Science (USA).
C1 Univ Helsinki, Dept Psychol, FIN-00014 Helsinki, Finland.
   Turku Univ, Dept Med, FIN-20520 Turku, Finland.
C3 University of Helsinki; University of Turku
EM liisa.keltikangas-jarvinen@helsinki.fi
RI Ravaja, Niklas/D-1532-2013
OI Ravaja, Niklas/0000-0003-1876-8731
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NR 56
TC 25
Z9 25
U1 0
U2 3
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0091-7435
EI 1096-0260
J9 PREV MED
JI Prev. Med.
PD JAN
PY 2003
VL 36
IS 1
BP 55
EP 63
DI 10.1006/pmed.2002.1125
PG 9
WC Public, Environmental & Occupational Health; Medicine, General &
   Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; General & Internal Medicine
GA 630FR
UT WOS:000180097300007
PM 12473425
DA 2025-06-11
ER

PT J
AU Ali, EF
   MacKay, JC
   Graitson, S
   James, JS
   Cayer, C
   Audet, MC
   Kent, P
   Abizaid, A
   Merali, Z
AF Ali, Eliza Fatima
   MacKay, Jennifer Christine
   Graitson, Samantha
   James, Jonathan Stewart
   Cayer, Christian
   Audet, Marie-Claude
   Kent, Pamela
   Abizaid, Alfonso
   Merali, Zul
TI Palatable Food Dampens the Long-Term Behavioral and Endocrine Effects of
   Juvenile Stressor Exposure but May Also Provoke Metabolic Syndrome in
   Rats
SO FRONTIERS IN BEHAVIORAL NEUROSCIENCE
LA English
DT Article
DE juvenile stress; palatable food; metabolic syndrome; dopamine receptors;
   social interaction; nucleus accumbens; prefrontal cortex; HPA-axis
ID HIGH-FAT DIET; CHRONIC-MILD STRESS; EARLY-LIFE STRESS;
   NUCLEUS-ACCUMBENS; GENE-EXPRESSION; RECEPTOR EXPRESSION; PREPUBERTAL
   PERIOD; PRENATAL STRESS; INDUCED OBESITY; CAFETERIA DIET
AB The juvenile period is marked by a reorganization and growth of important brain regions including structures associating with reward seeking behaviors such as the nucleus accumbens (NA) and prefrontal cortex (PFC). These changes are impacted by stressors during the juvenile period and may lead to a predisposition to stress induced psychopathology and abnormal development of brain reward systems. Like in humans, adult rodents engage certain coping mechanisms such as increases in the consumption of calorie-rich palatable foods to reduce stress, but this behavior can lead to obesity and metabolic disorders. In this study, we examined whether stressors during the juvenile period led to increased caloric intake when a palatable diet was accessible, and whether this diet attenuated adult stress responses. In addition, we examined if the stress buffering effects produced by the palatable diet were also accompanied by an offset propensity towards obesity, and by alterations in mRNA expression of dopamine (DA) receptors in the NA and PFC in adulthood. To this end, juvenile male Wistar rats underwent episodic stressor exposure (forced swim, elevated platform stress and restraint) on postnatal days (PD) 27-29 and received access to regular chow or daily limited access to a palatable diet until adulthood. At the age of 2 months, rats were tested on a social interaction test that screens for anxiety-like behaviors and their endocrine responses to an acute stressor. Animals were sacrificed, and their brains processed to detect differences in DA receptor subtype expression in the PFC and NA using qPCR. Results showed that rats that were stressed during the juvenile period displayed higher social anxiety and a sensitized corticosterone response as adults and these effects were attenuated by access to the palatable diet. Nevertheless, rats that experienced juvenile stress and consumed a palatable diet showed greater adiposity in adulthood. Interestingly, the same group displayed greater mRNA expression of DA receptors at the NA. This suggests that access to a palatable diet mitigates the behavioral and endocrine effects of juvenile stressor exposure in adulthood, but at the cost of metabolic imbalances and a sensitized system.
C1 [Ali, Eliza Fatima; MacKay, Jennifer Christine; Graitson, Samantha; James, Jonathan Stewart; Cayer, Christian; Audet, Marie-Claude; Kent, Pamela; Merali, Zul] Univ Ottawa, Royals Inst Mental Hlth Res, Ottawa, ON, Canada.
   [Ali, Eliza Fatima; Audet, Marie-Claude; Abizaid, Alfonso; Merali, Zul] Carleton Univ, Dept Neurosci, Ottawa, ON, Canada.
   [Cayer, Christian; Merali, Zul] Univ Ottawa, Sch Psychol, Ottawa, ON, Canada.
   [Audet, Marie-Claude; Merali, Zul] Univ Ottawa, Dept Cellular & Mol Med, Ottawa, ON, Canada.
C3 University of Ottawa; Carleton University; University of Ottawa;
   University of Ottawa
RP Merali, Z (corresponding author), Univ Ottawa, Royals Inst Mental Hlth Res, Ottawa, ON, Canada.; Merali, Z (corresponding author), Carleton Univ, Dept Neurosci, Ottawa, ON, Canada.; Merali, Z (corresponding author), Univ Ottawa, Sch Psychol, Ottawa, ON, Canada.; Merali, Z (corresponding author), Univ Ottawa, Dept Cellular & Mol Med, Ottawa, ON, Canada.
EM zul.merali@uottawa.ca
RI Kent, Pamela/KWT-4413-2024
OI Rose, J Christine/0000-0002-9573-2399; Audet,
   Marie-Claude/0000-0002-3694-1510
FU Canadian Institutes of Health Research (CIHR) [275228, CIHR 106445]
FX This study was funded by Canadian Institutes of Health Research (CIHR)
   275228 granted to ZM and CIHR 106445 granted to AA.
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NR 80
TC 10
Z9 12
U1 1
U2 4
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1662-5153
J9 FRONT BEHAV NEUROSCI
JI Front. Behav. Neurosci.
PD SEP 19
PY 2018
VL 12
AR 216
DI 10.3389/fnbeh.2018.00216
PG 14
WC Behavioral Sciences; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Behavioral Sciences; Neurosciences & Neurology
GA GU1PF
UT WOS:000445036700001
PM 30283308
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Vlahakos, D
   Marathias, K
   Vlahakos, V
   Papademetriou, V
AF Vlahakos, Demetrios
   Marathias, Katerina
   Vlahakos, Vassilios
   Papademetriou, Vasilios
TI Polycythemia hypertonica revisited: a metabolic syndrome with high-renin
   hypertension?
SO JOURNAL OF HUMAN HYPERTENSION
LA English
DT Article
ID ANGIOTENSIN-SYSTEM INHIBITORS; STRESS POLYCYTHEMIA; ANEMIA;
   ERYTHROPOIETIN; ASSOCIATION; HEMATOCRIT; ACTIVATION; DISEASE
C1 [Vlahakos, Demetrios; Vlahakos, Vassilios] Natl & Kapodistrian Univ Athens, ATTIKON Univ Hosp, 1 Rimini St, Athens, Greece.
   [Marathias, Katerina] Onassis Cardiac Surg Ctr, 356 Sigrou Ave, Kallithea 17674, Greece.
   [Vlahakos, Vassilios] Evagelismos Hosp, 45-47 Ipsilantou St, Athens 10676, Greece.
   [Papademetriou, Vasilios] VA Med Ctr, 50 Irving Str NW, Washington, DC 20422 USA.
   [Papademetriou, Vasilios] Georgetown Univ, 50 Irving Str NW, Washington, DC 20422 USA.
C3 University Hospital Attikon; National & Kapodistrian University of
   Athens; Onassis Cardiac Surgery Center; Georgetown University
RP Papademetriou, V (corresponding author), VA Med Ctr, 50 Irving Str NW, Washington, DC 20422 USA.; Papademetriou, V (corresponding author), Georgetown Univ, 50 Irving Str NW, Washington, DC 20422 USA.
EM v.papademetriou@yahoo.com
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NR 26
TC 0
Z9 0
U1 0
U2 2
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0950-9240
EI 1476-5527
J9 J HUM HYPERTENS
JI J. Hum. Hypertens.
PD JUN
PY 2022
VL 36
IS 6
BP 585
EP 587
DI 10.1038/s41371-021-00620-6
EA JAN 2022
PG 3
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 2I6IS
UT WOS:000741562000001
PM 35013571
DA 2025-06-11
ER

PT J
AU Loucks, EB
   Rehkopf, DH
   Thurston, RC
   Kawachi, I
AF Loucks, Eric B.
   Rehkopf, David H.
   Thurston, Rebecca C.
   Kawachi, Ichiro
TI Socioeconomic disparities in metabolic syndrome differ by gender:
   Evidence from NHANES III
SO ANNALS OF EPIDEMIOLOGY
LA English
DT Article
DE social class; education; income; metabolic syndrome
ID ARTERY RISK DEVELOPMENT; CORONARY-HEART-DISEASE; NUTRITION EXAMINATION
   SURVEY; 3RD NATIONAL-HEALTH; YOUNG-ADULTS; CARDIOVASCULAR-DISEASE;
   WOMEN; OBESITY; DEPRESSION; MEN
AB PURPOSE: The aim of the study is to examine whether socioeconomic position (SEP) is associated with metabolic syndrome and whether the association differs by gender and race/ethnicity.
   METHODS: Study participants were from the Third National Health and Nutrition Examination Survey. SEP was measured by using education and poverty income ratio (PIR). Metabolic syndrome was measured according to the National Institutes of Health guidelines. Multivariable-adjusted logistic regression analyses were performed.
   RESULTS: Low education (< 12 years) was associated with metabolic syndrome in women (odds ratio [OR], 1.77; 95% confidence interval [CI], 1.39-2.24) and less so in men (OR, 1.27; 95% CI, 0.97-1.66) versus more than 12 years of education. For income, low PIR (<= 1) was related to metabolic syndrome in women (OR, 1.81; 95% CI, 1.37-2.40) and not men (OR, 0.98; 95% CI, 0.74-1.29) versus PIR greater than 3. SEP was associated with metabolic syndrome in white, black, and Mexican-American women. Education was associated with all five metabolic syndrome components in women and only three components (abdominal obesity, hypertension, and hyperglycemia) in men.
   CONCLUSIONS: SEP is associated with metabolic syndrome in white, black, and Mexican-American women and is associated less strongly in men. The findings provide biologic mechanistic evidence of previously documented associations between SEP and such clinical disorders as type 2 diabetes and coronary heart disease. These results underscore the clinical significance of SEP, particularly for women.
C1 McGill Univ, Douglas Hosp, Res Ctr, Montreal, PQ H4H 1R3, Canada.
   McGill Univ, Dept Psychiat & Epidemiol, Montreal, PQ H4H 1R3, Canada.
   McGill Univ, Dept Biostat & Occupat Hlth, Montreal, PQ H4H 1R3, Canada.
   Harvard Univ, Sch Med, Dept Soc Human Dev & Hlth, Boston, MA 02115 USA.
   Univ Pittsburgh, Sch Med, Dept Psychiat, Pittsburgh, PA USA.
C3 McGill University; McGill University; McGill University; Harvard
   University; Harvard Medical School; Pennsylvania Commonwealth System of
   Higher Education (PCSHE); University of Pittsburgh
RP Loucks, EB (corresponding author), McGill Univ, Douglas Hosp, Res Ctr, 6875 LaSalle Blvd,Off E-4116, Montreal, PQ H4H 1R3, Canada.
EM eric.loucks@douglas.megill.ca
RI Loucks, Eric/I-1272-2014; Kawachi, Ichiro/A-8329-2009
OI Rehkopf, David/0000-0002-7597-6513
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NR 29
TC 176
Z9 199
U1 0
U2 18
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1047-2797
J9 ANN EPIDEMIOL
JI Ann. Epidemiol.
PD JAN
PY 2007
VL 17
IS 1
BP 19
EP 26
DI 10.1016/j.annepidem.2006.07.002
PG 8
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA 123FI
UT WOS:000243281300003
PM 17140811
DA 2025-06-11
ER

PT J
AU Vogelzangs, N
   Duivis, HE
   Beekman, ATF
   Kluft, C
   Neuteboom, J
   Hoogendijk, W
   Smit, JH
   de Jonge, P
   Penninx, BWJH
AF Vogelzangs, N.
   Duivis, H. E.
   Beekman, A. T. F.
   Kluft, C.
   Neuteboom, J.
   Hoogendijk, W.
   Smit, J. H.
   de Jonge, P.
   Penninx, B. W. J. H.
TI Association of depressive disorders, depression characteristics and
   antidepressant medication with inflammation
SO TRANSLATIONAL PSYCHIATRY
LA English
DT Article
DE antidepressants; cohort study; depression characteristics; depressive
   disorder; inflammation
ID PITUITARY-ADRENAL AXIS; MAJOR DEPRESSION; TREATMENT RESPONSE; METABOLIC
   SYNDROME; HEALTH BEHAVIORS; SEX-DIFFERENCES; CYTOKINES; ANXIETY; RISK;
   INTERLEUKIN-6
AB Growing evidence suggests that immune dysregulation may be involved in depressive disorders, but the exact nature of this association is still unknown and may be restricted to specific subgroups. This study examines the association between depressive disorders, depression characteristics and antidepressant medication with inflammation in a large cohort of controls and depressed persons, taking possible sex differences and important confounding factors into account. Persons (18-65 years) with a current (N = 1132) or remitted (N = 789) depressive disorder according to DSM-IV criteria and healthy controls (N = 494) were selected from the Netherlands Study of Depression and Anxiety. Assessments included clinical characteristics (severity, duration and age of onset), use of antidepressant medication and inflammatory markers (C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha)). After adjustment for sociodemographics, currently depressed men, but not women, had higher levels of CRP (1.33 versus 0.92 mg l(-1), P<0.001, Cohen's d = 0.32) and IL-6 (0.88 versus 0.72 pg ml(-1), P = 0.01, Cohen's d = 0.23) than non-depressed peers. Associations reduced after considering lifestyle and disease indicators - especially body mass index - but remained significant for CRP. After full adjustment, highest inflammation levels were found in depressed men with an older age of depression onset (CRP, TNF-alpha). Furthermore, inflammation was increased in men using serotonin-norepinephrine reuptake inhibitors (CRP, IL-6) and in men and women using tri- or tetracyclic antidepressants (CRP), but decreased among men using selective serotonin reuptake inhibitors (IL-6). In conclusion, elevated inflammation was confirmed in depressed men, especially those with a late-onset depression. Specific antidepressants may differ in their effects on inflammation. Translational Psychiatry (2012) 2, e79; doi:10.1038/tp.2012.8; published online 21 February 2012
C1 [Vogelzangs, N.; Beekman, A. T. F.; Smit, J. H.; Penninx, B. W. J. H.] Vrije Univ Amsterdam Med Ctr, Dept Psychiat, NL-1081 HL Amsterdam, Netherlands.
   [Vogelzangs, N.; Beekman, A. T. F.; Smit, J. H.; Penninx, B. W. J. H.] Vrije Univ Amsterdam Med Ctr, EMGO Inst Hlth & Care Res, NL-1081 HL Amsterdam, Netherlands.
   [Duivis, H. E.] Tilburg Univ, Ctr Res Psychol Somat Dis, NL-5000 LE Tilburg, Netherlands.
   [Kluft, C.; Neuteboom, J.] Good Biomarker Sci, Leiden, Netherlands.
   [Hoogendijk, W.] Erasmus MC, Dept Psychiat, Rotterdam, Netherlands.
   [de Jonge, P.; Penninx, B. W. J. H.] Univ Med Ctr Groningen, Dept Psychiat, NL-9713 AV Groningen, Netherlands.
   [Penninx, B. W. J. H.] Leiden Univ Med Ctr, Dept Psychiat, Leiden, Netherlands.
   [Penninx, B. W. J. H.] Vrije Univ Amsterdam Med Ctr, NL-1081 HL Amsterdam, Netherlands.
C3 Vrije Universiteit Amsterdam; VU UNIVERSITY MEDICAL CENTER; Vrije
   Universiteit Amsterdam; VU UNIVERSITY MEDICAL CENTER; Tilburg
   University; Erasmus University Rotterdam; Erasmus MC; University of
   Groningen; Leiden University; Leiden University Medical Center (LUMC);
   Vrije Universiteit Amsterdam; VU UNIVERSITY MEDICAL CENTER
RP Vogelzangs, N (corresponding author), Vrije Univ Amsterdam Med Ctr, Dept Psychiat, AJ Ernststr 1187, NL-1081 HL Amsterdam, Netherlands.
EM n.vogelzangs@vumc.nl
RI Sundström, Johan/IAP-6197-2023; Penninx, Brenda/S-7627-2017; Beekman,
   Aartjan T./LUZ-6919-2024; de Jonge, Peter/L-6395-2013
OI Hoogendijk, Witte/0000-0002-0225-4966; de Jonge,
   Peter/0000-0002-0866-6929
FU Netherlands Organization for Health Research and Development (Zon-Mw)
   [10-000-1002]; VU University Medical Center; GGZ inGeest; Arkin; Leiden
   University Medical Center; GGZ Rivierduinen; University Medical Center
   Groningen; Lentis; GGZ Friesland; GGZ Drenthe; Institute for Quality of
   Health Care (IQ Healthcare); Netherlands Institute for Health Services
   Research (NIVEL); Netherlands Institute of Mental Health and Addiction
   (Trimbos); EMGO Institute for Health and Care Research; Neuroscience
   Campus Amsterdam
FX The infrastructure for the NESDA study (www.nesda.nl) is funded through
   the Geestkracht program of the Netherlands Organization for Health
   Research and Development (Zon-Mw, grant number 10-000-1002) and is
   supported by participating universities and mental health care
   organizations (VU University Medical Center, GGZ inGeest, Arkin, Leiden
   University Medical Center, GGZ Rivierduinen, University Medical Center
   Groningen, Lentis, GGZ Friesland, GGZ Drenthe, Institute for Quality of
   Health Care (IQ Healthcare), Netherlands Institute for Health Services
   Research (NIVEL) and Netherlands Institute of Mental Health and
   Addiction (Trimbos). Data analyses were supported through a fellowship
   (NV) from the EMGO Institute for Health and Care Research. Assaying of
   inflammatory markers was supported by the Neuroscience Campus Amsterdam.
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NR 56
TC 260
Z9 276
U1 3
U2 37
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 2158-3188
J9 TRANSL PSYCHIAT
JI Transl. Psychiatr.
PD FEB
PY 2012
VL 2
AR e79
DI 10.1038/tp.2012.8
PG 9
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychiatry
GA 104JW
UT WOS:000315989800004
PM 22832816
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Cicekliyurt, MMH
   Ögretmen, Z
AF Cicekliyurt, Meliha Merve Hiz
   Ogretmen, Zerrin
TI Clinical features and comorbidities in psoriasis. A retrospective study
SO PRZEGLAD DERMATOLOGICZNY
LA English
DT Article
DE psoriasis; obesity; hypertension; diabetes; depression
ID RISK; HYPERTENSION; SMOKING; INDEX
AB Introduction: Patients with psoriasis may develop several comorbidities.
   Objective: To determine the clinical characteristics and comorbidities associated with psoriasis.
   Material and methods: This retrospective case-control study involved 422 adult patients with psoriasis and 444 healthy individuals. The inclusion criteria for patients were: over 18 years old and at least one-year history of confirmed psoriasis. Data, such as age, gender, body mass index, smoking, and alcohol consumption habits were analyzed in addition to detailed physical and dermatological examination.
   Results: The common comorbidities in patients with psoriasis were depression (n = 144, 34%), hypertension (n = 168, 39.81%), diabetes mellitus (n = 100, 23.7%), coronary artery disease (n = 59, 13.9%) and metabolic syndrome (n = 67, 15.88%). The most common conditions in the control group were hypertension (n = 62, 13.96%), hyperlipidemia (n = 62, 13.96%), diabetes mellitus (n = 42; 9.46%), metabolic syndrome (n = 32; 7.21%) and coronary artery disease (5.41%). Patients with psoriasis are at a higher risk for obesity compared to healthy controls (OR = 1.99; p < 0.0001). In addition, smoking and alcohol consumption were significantly higher in patients with psoriasis (p < 0.0001).
   Conclusions: These results indicate an increased prevalence of obesity, hyperlipidemia, hypertension, cardiovascular diseases, diabetes, metabolic syndrome, and depression in patients with psoriasis.
C1 [Cicekliyurt, Meliha Merve Hiz] Canakkale Onsekiz Mart Univ, Fac Med, Dept Med Biol, Canakkale, Turkey.
   [Ogretmen, Zerrin] Canakkale Onsekiz Mart Univ, Fac Med, Dept Dermatol, Canakkale, Turkey.
C3 Canakkale Onsekiz Mart University; Canakkale Onsekiz Mart University
RP Cicekliyurt, MMH (corresponding author), Canakkale Onsekiz Mart Univ, Fac Med, Dept Med Biol, Canakkale, Turkey.
EM mervemeliha@comu.edu.tr
RI HIZ, Meliha Merve/AFM-3576-2022
OI HIZ, Meliha Merve/0000-0003-4303-9717
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NR 31
TC 3
Z9 3
U1 1
U2 3
PU TERMEDIA PUBLISHING HOUSE LTD
PI POZNAN
PA KLEEBERGA 2, POZNAN, 61-615, POLAND
SN 0033-2526
EI 2084-9893
J9 PRZ DERMATOL
JI Prz. Dermatol.
PY 2022
VL 109
IS 4
BP 263
EP 271
DI 10.5114/dr.2022.123982
PG 9
WC Dermatology
WE Emerging Sources Citation Index (ESCI)
SC Dermatology
GA 8H4PK
UT WOS:000921016100001
OA gold
DA 2025-06-11
ER

PT J
AU Ma, J
   Huang, ZY
   Chen, J
   Wang, GH
AF Ma, Jun
   Huang, Zhengyuan
   Chen, Jing
   Wang, Gaohua
TI Biological Susceptibility of Patients with Schizophrenia to Metabolic
   Syndrome: A Review
SO ALPHA PSYCHIATRY
LA English
DT Review
DE schizophrenia; metabolic disorder; genetics; lifestyle; antipsychotic
   drug
ID GENE POLYMORPHISMS; BIPOLAR DISORDER; GUT MICROBIOME; DRUG-NAIVE;
   ASSOCIATION; 1ST-EPISODE; INSULIN; KYNURENINE; PARAMETERS; GHRELIN
AB Schizophrenia (SCZ) is a debilitating, chronic mental disorder with an elusive etiology that significantly impacts the life expectancy of affected individuals. Metabolic syndrome (MetS) is a condition characterized by a combination of factors that increase the risk of cardiovascular diseases. MetS is more prevalent in individuals with SCZ and is a major factor that contributes to their reduced lifespan. This review scrutinizes the biological factors that predispose patients with SCZ to MetS, among which, genetic predisposition, dietary and lifestyle modifications, and the use of antipsychotic drugs (APs) play a significant role. The metabolic side effects of APs have been well studied. While studies have shed light on potential interventions to manage MetS in patients with SCZ, identifying precise biological targets to treat SCZ remains challenging. Therefore, further studies are warranted to enhance our comprehension of the intricate mechanisms underlying the susceptibility of patients with SCZ to MetS. These studies will be crucial in developing effective, targeted therapeutic strategies to treat MetS in this vulnerable population.
C1 [Ma, Jun; Huang, Zhengyuan; Wang, Gaohua] Wuhan Univ, Dept Psychiat, Renmin Hosp, Wuhan 430060, Hubei, Peoples R China.
   [Chen, Jing] Wuhan Polytech Univ, Coll Life Sci & Technol, Wuhan 430023, Hubei, Peoples R China.
   [Wang, Gaohua] Wuhan Univ, TaiKang Ctr Life & Med Sci, Wuhan 430071, Hubei, Peoples R China.
   [Wang, Gaohua] Wuhan Univ, Inst Neuropsychiat, Renmin Hosp, Wuhan 430060, Hubei, Peoples R China.
C3 Wuhan University; Wuhan Polytechnic University; Wuhan University; Wuhan
   University
RP Wang, GH (corresponding author), Wuhan Univ, Dept Psychiat, Renmin Hosp, Wuhan 430060, Hubei, Peoples R China.; Wang, GH (corresponding author), Wuhan Univ, TaiKang Ctr Life & Med Sci, Wuhan 430071, Hubei, Peoples R China.; Wang, GH (corresponding author), Wuhan Univ, Inst Neuropsychiat, Renmin Hosp, Wuhan 430060, Hubei, Peoples R China.
EM wgh6402@whu.edu.cn
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NR 106
TC 0
Z9 0
U1 1
U2 1
PU IMR PRESS
PI ROBINSON
PA 112 ROBINSON RD, ROBINSON, SINGAPORE
EI 2757-8038
J9 ALPHA PSYCHIAT
JI Alpha Psychiat.
PD APR 22
PY 2025
VL 26
IS 2
AR 39896
DI 10.31083/AP39896
PG 11
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychiatry
GA 2CC7Z
UT WOS:001479122700001
PM 40352077
DA 2025-06-11
ER

PT J
AU Matsui, H
   Ando, K
   Kawarazaki, H
   Nagae, A
   Fujita, M
   Shimosawa, T
   Nagase, M
   Fujita, T
AF Matsui, Hiromitsu
   Ando, Katsuyuki
   Kawarazaki, Hiroo
   Nagae, Ai
   Fujita, Megumi
   Shimosawa, Tatsuo
   Nagase, Miki
   Fujita, Toshiro
TI Salt excess causes left ventricular diastolic dysfunction in rats with
   metabolic disorder
SO HYPERTENSION
LA English
DT Article
DE metabolic syndrome; salt intake; cardiac diastolic function; oxidative
   stress; mineralocorticoid receptor
ID OXIDATIVE STRESS; MINERALOCORTICOID RECEPTOR; SUPEROXIDE-DISMUTASE;
   HYPERTENSIVE-RATS; CARDIAC FIBROSIS; HEART-FAILURE; ALDOSTERONE;
   EPLERENONE; EXPRESSION; RELAXATION
AB Metabolic syndrome is a highly predisposing condition for cardiovascular disease and could be a cause of excess salt-induced organ damage. Recently, several investigators have demonstrated that salt loading causes left ventricular diastolic dysfunction associated with increased oxidative stress and mineralocorticoid receptor activation. We, therefore, investigated whether excess salt induces cardiac diastolic dysfunction in metabolic syndrome via increased oxidative stress and upregulation of mineralocorticoid receptor signals. Thirteen- week- old spontaneously hypertensive rats and SHR/ NDmcr- cps, the genetic model of metabolic syndrome, were fed a normal salt ( 0.5% NaCl) or high- salt ( 8% NaCl) diet for 4 weeks. In SHR/ NDmcr- cps, salt loading induced severe hypertension, abnormal left ventricular relaxation, and perivascular fibrosis. Salt- loaded SHR/ NDmcr- cps also exhibited overproduction of reactive oxygen species and upregulation of mineralocorticoid receptor - dependent gene expression, such as Na+/H+ exchanger-1 and serumand glucocorticoid-inducible kinase-1 in the cardiac tissue. However, in spontaneously hypertensive rats, salt loading did not cause these cardiac abnormalities despite a similar increase in blood pressure. An antioxidant, tempol, prevented salt-induced diastolic dysfunction, perivascular fibrosis, and upregulation of mineralocorticoid receptor signals in SHR/ NDmcr- cps. Moreover, a selective mineralocorticoid receptor antagonist, eplerenone, prevented not only diastolic dysfunction but also overproduction of reactive oxygen species in salt-loaded SHR/ NDmcr- cps. These results suggest that metabolic syndrome is a predisposed condition for salt-induced left ventricular diastolic dysfunction, possibly via increased oxidative stress and enhanced mineralocorticoid receptor signals.
C1 [Matsui, Hiromitsu; Ando, Katsuyuki; Kawarazaki, Hiroo; Nagae, Ai; Fujita, Megumi; Shimosawa, Tatsuo; Nagase, Miki; Fujita, Toshiro] Univ Tokyo, Dept Internal Med, Fac Med, Bunkyo Ku, Tokyo 1138655, Japan.
C3 University of Tokyo
RP Fujita, T (corresponding author), Univ Tokyo, Dept Nephrol & Endocrinol, Fac Med, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1138655, Japan.
EM fujita-dis@h.u-tokyo.ac.jp
RI Shimosawa, Tatsuo/A-2920-2015
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NR 39
TC 61
Z9 62
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0194-911X
EI 1524-4563
J9 HYPERTENSION
JI Hypertension
PD AUG
PY 2008
VL 52
IS 2
BP 287
EP 294
DI 10.1161/HYPERTENSIONAHA.108.111815
PG 8
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 329QA
UT WOS:000257882300023
PM 18606904
OA Green Submitted, Bronze
DA 2025-06-11
ER

PT J
AU Sinha, R
   Jastreboff, AM
AF Sinha, Rajita
   Jastreboff, Ania M.
TI Stress as a Common Risk Factor for Obesity and Addiction
SO BIOLOGICAL PSYCHIATRY
LA English
DT Review
DE Addiction; metabolism; neuroendocrine; obesity; reward; stress
ID WEIGHT-LOSS MAINTENANCE; PITUITARY-ADRENAL AXIS; BODY-MASS INDEX;
   FOOD-INTAKE; METABOLIC SYNDROME; INSULIN-RESISTANCE; ABDOMINAL OBESITY;
   EATING BEHAVIOR; NERVOUS-SYSTEM; PSYCHOLOGICAL STRESS
AB Stress is associated with obesity, and the neurobiology of stress overlaps significantly with that of appetite and energy regulation. This review will discuss stress, allostasis, the neurobiology of stress and its overlap with neural regulation of appetite, and energy homeostasis. Stress is a key risk factor in the development of addiction and in addiction relapse. High levels of stress changes eating patterns and augments consumption of highly palatable (HP) foods, which in turn increases incentive salience of HP foods and allostatic load. The neurobiological mechanisms by which stress affects reward pathways to potentiate motivation and consumption of HP foods as well as addictive drugs is discussed. With enhanced incentive salience of HP foods and overconsumption of these foods, there are adaptations in stress and reward circuits that promote stress-related and HP food-related motivation as well as concomitant metabolic adaptations, including alterations in glucose metabolism, insulin sensitivity, and other hormones related to energy homeostasis. These metabolic changes in turn might also affect dopaminergic activity to influence food motivation and intake of HP foods. An integrative heuristic model is proposed, wherein repeated high levels of stress alter the biology of stress and appetite/energy regulation, with both components directly affecting neural mechanisms contributing to stress-induced and food cue-induced HP food motivation and engagement in overeating of such foods to enhance risk of weight gain and obesity. Future directions in research are identified to increase understanding of the mechanisms by which stress might increase risk of weight gain and obesity.
C1 [Sinha, Rajita] Yale Univ, Sch Med, Dept Psychiat, Yale Stress Ctr, New Haven, CT 06519 USA.
   [Sinha, Rajita] Yale Univ, Sch Med, Ctr Child Study, New Haven, CT 06519 USA.
   [Sinha, Rajita] Yale Univ, Sch Med, Dept Neurobiol, New Haven, CT 06519 USA.
   [Jastreboff, Ania M.] Yale Univ, Sch Med, Dept Internal Med, New Haven, CT 06519 USA.
   [Jastreboff, Ania M.] Yale Univ, Sch Med, Sect Pediat Endocrinol, Dept Pediat, New Haven, CT 06519 USA.
C3 Yale University; Yale University; Yale University; Yale University; Yale
   University
RP Sinha, R (corresponding author), Yale Univ, Sch Med, Dept Psychiat Neurobiol & Child Study, Yale Stress Ctr, 2 Church St South,Suite 209, New Haven, CT 06519 USA.
EM rajita.sinha@yale.edu
OI SINHA, RAJITA/0000-0003-3012-4349
FU National Institute of Diabetes and Digestive and Kidney
   Diseases/National Institutes of Health [1K12DK094714-01]; National
   Institutes of Health Roadmap for Medical Research [UL1-DE019586,
   UL1-RR024139, PL1-DA024859]
FX This work was supported by National Institute of Diabetes and Digestive
   and Kidney Diseases/National Institutes of Health, 1K12DK094714-01, and
   the National Institutes of Health Roadmap for Medical Research Common
   Fund Grants UL1-DE019586, UL1-RR024139 (Yale Clinical and Translational
   Science Award), and the PL1-DA024859.
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NR 101
TC 409
Z9 481
U1 3
U2 245
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
EI 1873-2402
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD MAY 1
PY 2013
VL 73
IS 9
BP 827
EP 835
DI 10.1016/j.biopsych.2013.01.032
PG 9
WC Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Psychiatry
GA 126AO
UT WOS:000317583700010
PM 23541000
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Miner, MM
   Khera, M
   Bhattacharya, RK
   Blick, G
   Kushner, H
AF Miner, Martin M.
   Khera, Mohit
   Bhattacharya, Rajib K.
   Blick, Gary
   Kushner, Harvey
TI Baseline Data From the TRiUS Registry: Symptoms and Comorbidities of
   Testosterone Deficiency
SO POSTGRADUATE MEDICINE
LA English
DT Article
DE testosterone deficiency; hypogonadism; testosterone gel; TRiUS; Testim
   (R) registry
ID LATE-ONSET HYPOGONADISM; LOW SERUM TESTOSTERONE; MIDDLE-AGED MEN;
   ANDROGEN DEFICIENCY; METABOLIC SYNDROME; ERECTILE DYSFUNCTION; DARK
   SIDE; PREVALENCE; HORMONE; MORTALITY
AB Background: Testosterone deficiency (TD) is prevalent among men seeking medical attention and may be associated with other comorbidities. Objective: The Testim (R) Registry in the United States (TRiUS), a large, multicenter, prospective, 12-month observational cohort registry, was established to quantify symptoms and comorbidities of hypogonadal men in real-world clinical settings and to evaluate the effect of testosterone replacement therapy (TRT). Methods: Eligible TRiUS participants were hypogonadal men prescribed Testim (R) (1% testosterone gel) for the first time. Evaluated baseline parameters included: total testosterone (TT), free testosterone (FT), sex hormone-binding globulin (SHBG), prostate-specific antigen (PSA), anthropometrics (height, weight, waist, hip, and body mass index [BMI]), lipids, blood glucose, sexual dysfunction, mood/depression, and cardiovascular and metabolic risk factors. Parameters were correlated to TT and age using bivariate correlation and to the combination of TT and age using multiple linear regression. Results: TRiUS had 849 registrants (baseline TT: 286.5 +/- 151.8 ng/dL; FT: 40.8 +/- 62.1 pg/mL; SHBG: 28.2 +/- 15.0 nmol/L; PSA: 1.12 +/- 1.11 ng/mL). Eighty-six percent were overweight/obese, with a BMI >= 25 kg/m(2), and 57% were aged 40 to 59 years, with a mean (+/- standard deviation) age of 52.1 +/- 12.3 years. Total testosterone levels were significantly lower in men aged >= 65 years. The most common comorbid conditions and cardiovascular risk factors included: smoking, metabolic syndrome, hypertension, dyslipidemia, and coronary artery disease. Weak but statistically significant inverse correlations were noted between TT and sexual dysfunction, fasting glucose, systolic blood pressure, BMI, and Framingham risk scores. Patients with obesity or metabolic syndrome had significantly lower TT levels, particularly among younger and middle-aged patients. Conclusions: Untreated hypogonadal middle-aged men exhibited a high prevalence of cardiometabolic risk factors that were correlated to TT levels. This suggests that TD is associated with adverse medical conditions that pose serious health risks, especially in a younger age demographic than previously thought. Clinicians may want to consider TT testing in unhealthy, middle-aged patients with symptoms of TD.
C1 [Miner, Martin M.] Brown Univ, Warren Alpert Sch Med, Miriam Hosp, Mens Hlth Ctr, Providence, RI 02906 USA.
   [Khera, Mohit] Baylor Coll Med, Scott Dept Urol, Houston, TX 77030 USA.
   [Bhattacharya, Rajib K.] Univ Kansas, Med Ctr, Kansas City, KS 66103 USA.
   [Blick, Gary] Circle Med LLC, Norwalk, CT USA.
   [Kushner, Harvey] Auxilium Pharmaceut, Malvern, PA USA.
C3 Brown University; Lifespan Health Rhode Island; Miriam Hospital; Baylor
   College of Medicine; University of Kansas; University of Kansas Medical
   Center
RP Miner, MM (corresponding author), Brown Univ, Warren Alpert Sch Med, Miriam Hosp, Mens Hlth Ctr, 164 Summit Ave, Providence, RI 02906 USA.
EM martin_miner@brown.edu
FU Auxilium Pharmaceuticals
FX Funding to support this study and the preparation of this manuscript was
   provided by Auxilium Pharmaceuticals. This manuscript was prepared
   according to the International Society for Medical Publication
   Professionals' "Good Publication Practice for Communicating
   Company-Sponsored Medical Research: the GPP2 Guidelines." The authors
   wish to thank Dat Nguyen, PharmD, of Auxilium Pharmaceuticals, and also
   Tara Gupta, PhD, of MedVal Scientific Information Services, LLC, for
   providing medical writing and editorial assistance.
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NR 47
TC 18
Z9 20
U1 0
U2 2
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0032-5481
EI 1941-9260
J9 POSTGRAD MED
JI Postgrad. Med.
PD MAY
PY 2011
VL 123
IS 3
BP 17
EP 27
DI 10.3810/pgm.2011.05.2280
PG 11
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 983DL
UT WOS:000307098200002
PM 21566412
DA 2025-06-11
ER

PT J
AU Arslan, H
   Yorgancilar, N
   Kose, O
   Aslan, MG
   Altin, A
   Bayrakdar, SK
   Yemenoglu, H
   Findik, H
   Yilmaz, A
AF Arslan, Hatice
   Yorgancilar, Nur
   Kose, Oguz
   Aslan, Mehmet Gokhan
   Altin, Ahmet
   Bayrakdar, Sevda Kurt
   Yemenoglu, Hatice
   Findik, Huseyin
   Yilmaz, Adnan
TI Periodontitis Provokes Retinal Neurodegenerative Effects of Metabolic
   Syndrome: A Cross-Sectional Study
SO DENTISTRY JOURNAL
LA English
DT Article
DE periodontitis; metabolic syndrome; oxidative stress; neurodegeneration;
   optic coherence tomography
ID OPTICAL COHERENCE TOMOGRAPHY; FIBER LAYER THICKNESS; OXIDATIVE STRESS;
   DISEASE; CLASSIFICATION; INFLAMMATION; CYTOKINES; MARKERS; SERUM; INDEX
AB Background: This cross-sectional study aims to investigate the retino-choroidal degenerative effects of periodontitis, metabolic syndrome (Mets), and the combination of these diseases using optical coherence tomography (OCT) measurements. Methods: Ninety-two patients selected according to inclusion criteria were divided into four groups: systemically and periodontally healthy (control), systemically healthy periodontitis (PD), periodontally healthy metabolic syndrome (MetS), and periodontitis and metabolic syndrome combined (PD-MetS). The systemic inflammatory-oxidative effects of periodontitis and MetS were biochemically evaluated using the serum TNF-alpha level, IL-1 beta/IL-10 ratio, and oxidative stress index (OSI: TOS/TAS). Retinal (AMT, pRNFLT, and GCL + T) and choroidal (SFCT) morphometric measurements and vascular evaluations (foveal capillary density) were performed via OCT Angio with swept-source technology. Results: Both periodontitis and Mets cause systemic inflammatory stress characterized by significant increases in the IL-1 beta/IL-10 ratio and OSI (p < 0.05). Compared to the control group, the AMT was significantly thinner in the MetS group, the pRNFLT was significantly thinner in the PD-MetS group, and the SFCT was significantly thinner in both groups (p < 0.05). The GCL+ was slightly thicker in the Mets groups. (p > 0.05) Foveal capillary density did not differ significantly among the groups. (p > 0.05). Conclusions: Periodontitis-related inflammatory stress alone causes changes in retinal and subfoveal choroidal thicknesses that are not statistically significant. On the other hand, when combined with Mets, it may significantly provoke the retinal neurodegenerative effects of this disease.
C1 [Arslan, Hatice; Yorgancilar, Nur; Kose, Oguz; Yemenoglu, Hatice] Recep Tayyip Erdogan Univ, Sch Dent, Dept Periodontol, TR-53100 Rize, Turkiye.
   [Aslan, Mehmet Gokhan; Findik, Huseyin] Recep Tayyip Erdogan Univ, Dept Ophthalmol, Sch Med, TR-53100 Rize, Turkiye.
   [Altin, Ahmet] Istanbul Medipol Univ, Sch Dent, Dept Prosthodont, TR-34083 Istanbul, Turkiye.
   [Bayrakdar, Sevda Kurt] Eskisehir Osmangazi Univ, Sch Dent, Dept Periodontol, TR-26040 Eskisehir, Turkiye.
   [Yilmaz, Adnan] Recep Tayyip Erdogan Univ, Sch Med, Dept Biochem, TR-53100 Rize, Turkiye.
C3 Recep Tayyip Erdogan University; Recep Tayyip Erdogan University;
   Istanbul Medipol University; Eskisehir Osmangazi University; Recep
   Tayyip Erdogan University
RP Yorgancilar, N (corresponding author), Recep Tayyip Erdogan Univ, Sch Dent, Dept Periodontol, TR-53100 Rize, Turkiye.
EM hatice.seviker@erdogan.edu.tr; nur.yorgancilar@erdogan.edu.tr;
   oguz.kose@erdogan.edu.tr; mehmetgokhan.aslan@erdogan.edu.tr;
   ahmetaltin@outlook.com; sevda.kurtbayrakdar@ogu.edu.tr;
   hatice.yemenoglu@erdogan.edu.tr; huseyin.findik@erdogan.edu.tr;
   adnan.yilmaz@erdogan.edu.tr
RI kose, oguz/KHC-7197-2024; Aslan, Mehmet/AAJ-6940-2020; kurt bayrakdar,
   sevda/AFV-9029-2022; Fındık, Hüseyin/AGR-7064-2022; ALTIN,
   Ahmet/AAF-3791-2021; Yemenoglu, Hatice/KHD-2761-2024; yilmaz,
   adnan/ABB-9340-2020
OI Findik, Huseyin/0000-0001-7343-8757; Kose, Oguz/0000-0002-0318-2458;
   yilmaz, adnan/0000-0003-4842-1173
FU Scientific Research Fund of Recep Tayyip Erdogan University; 
   [Bap-TDH-2022-1421]
FX This study was supported by the Scientific Research Fund of Recep Tayyip
   Erdogan University (Bap-TDH-2022-1421).
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NR 47
TC 0
Z9 0
U1 5
U2 5
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2304-6767
J9 DENT J-BASEL
JI Dent. J.
PD NOV
PY 2024
VL 12
IS 11
AR 351
DI 10.3390/dj12110351
PG 12
WC Dentistry, Oral Surgery & Medicine
WE Emerging Sources Citation Index (ESCI)
SC Dentistry, Oral Surgery & Medicine
GA N6Y5J
UT WOS:001365769900001
PM 39590401
OA gold
DA 2025-06-11
ER

PT J
AU Holmes, ME
   Ekkekakis, P
   Eisenmann, JC
AF Holmes, M. E.
   Ekkekakis, P.
   Eisenmann, J. C.
TI The physical activity, stress and metabolic syndrome triangle: a guide
   to unfamiliar territory for the obesity researcher
SO OBESITY REVIEWS
LA English
DT Article
DE Cortisol; catecholamines; exercise; emotion
ID 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1; BRITISH CIVIL-SERVANTS;
   SYMPATHETIC NEURAL ACTIVATION; TRANSPORTER MESSENGER-RNA; EFFORT-REWARD
   IMBALANCE; PITUITARY-ADRENAL AXIS; CORONARY-HEART-DISEASE; BODY-FAT
   DISTRIBUTION; CARDIOVASCULAR REACTIVITY; WORK STRESS
AB P>Research aimed at deciphering the aetiology of obesity and the metabolic syndrome remains focused on two behavioural factors, namely diet and physical activity, even though epidemiologic research suggests that these two cornerstones of treatment and prevention account for only a small-to-moderate portion of the variance in these phenotypes. In recent years, this observation has prompted the intensified investigation of the pathogenic potential of factors that extend beyond the traditional concept of energy imbalance and examine the putative causes of this imbalance. Psychosocial stress has emerged as one such factor, raising the need for researchers to be informed about this expansive and complex literature. The purpose of this review is twofold (i) To introduce obesity researchers to fundamental concepts and historically important theoretical developments in the stress field and (ii) To outline the dyadic and triadic interactions between stress, physical activity and the metabolic syndrome. Although the expansion of the research focus to multiple, diverse and interacting putative causal agents will certainly increase the complexity of the research enterprise, this step seems essential for the comprehension and effective response to the continuing rise in the prevalence of obesity and the metabolic syndrome.
C1 [Holmes, M. E.; Eisenmann, J. C.] Michigan State Univ, Dept Kinesiol, Ctr Phys Act & Hlth, E Lansing, MI 48823 USA.
   [Ekkekakis, P.] Iowa State Univ, Dept Kinesiol, Ames, IA USA.
C3 Michigan State University; Iowa State University
RP Holmes, ME (corresponding author), Michigan State Univ, Dept Kinesiol, Ctr Phys Act & Hlth, 3 IM Sports Circle, E Lansing, MI 48823 USA.
EM holmes58@msu.edu
RI Holmes, Megan/AAX-6919-2021; Ekkekakis, Panteleimon/HCJ-0116-2022
OI Holmes, Megan/0000-0003-1716-6122
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NR 149
TC 55
Z9 67
U1 0
U2 17
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1467-7881
EI 1467-789X
J9 OBES REV
JI Obes. Rev.
PD JUL
PY 2010
VL 11
IS 7
BP 492
EP 507
DI 10.1111/j.1467-789X.2009.00680.x
PG 16
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism
GA 615XB
UT WOS:000279170300002
PM 19895413
DA 2025-06-11
ER

PT J
AU Roemmich, JN
   Smith, JR
   Epstein, LH
   Lambiase, M
AF Roemmich, James N.
   Smith, Jasmine R.
   Epstein, Leonard H.
   Lambiase, Maya
TI Stress reactivity and adiposity of youth
SO OBESITY
LA English
DT Article
DE children; abdominal obesity; body composition; cardiovascular disease
ID BODY-FAT DISTRIBUTION; CARDIOVASCULAR RISK-FACTORS;
   CORONARY-HEART-DISEASE; LEFT-VENTRICULAR MASS; BLOOD-PRESSURE;
   PSYCHOSOCIAL STRESS; METABOLIC SYNDROME; VISCERAL FAT;
   INSULIN-RESISTANCE; OVERWEIGHT
AB Objective: The relationship between stress reactivity and total or central adiposity in children has not been widely studied. Data from two studies were combined to determine the relationship between reactivity to interpersonal stress and the adiposity of children.
   Research Methods and Procedures: Stress reactivity to an interpersonal stressor (speech) was measured in 36 boys (9.8 +/- 1.3 years of age) and 27 girls (9.3 +/- 1.3 years of age). Total adiposity (percentage body fat) was estimated from skinfolds and central adiposity from the abdominal girth. Multiple regression was used to establish the associations of change in perceived stress and heart rate reactivity with adiposity. Age, sex, ethnicity, and baseline perceived stress and heart rate served as covariates for total adiposity. Fat mass was included as an additional covariate for the prediction of log abdominal girth (central adiposity).
   Results: Based on adjusted beta-weights, change in perceived stress (beta = 1.13, p <= 0.001) and heart rate reactivity (beta = 0.14, p <= 0.03) independently predicted percentage body fat. Heart rate reactivity (beta = 0.002, p <= 0.04) independently predicted log abdominal girth.
   Discussion: Reactivity to psychological stress may initiate the antecedents of cardiovascular disease before adolescence by increasing total and central adiposity. Future studies should determine whether stress reactivity increases the adiposity of youth by increasing their consumption of energy-dense snack foods and decreasing their willingness to be physically active.
C1 SUNY Buffalo, Sch Med & Biomed Sci, Dept Pediat, Div Behav Med, Buffalo, NY USA.
   SUNY Buffalo, Sch Publ Hlth & Hlth Prof, Dept Exercise & Nutr Sci, Buffalo, NY USA.
   SUNY Buffalo, Sch Publ Hlth & Hlth Prof, Dept Prevent & Social Med, Buffalo, NY USA.
C3 State University of New York (SUNY) System; University at Buffalo, SUNY;
   State University of New York (SUNY) System; University at Buffalo, SUNY;
   State University of New York (SUNY) System; University at Buffalo, SUNY
RP Roemmich, JN (corresponding author), SUNY Buffalo, Dept Pediat, Div Behav Med, Farber Hall, Rm G56, 3435 Main St, Bldg 26, Buffalo, NY 14214 USA.
EM roemmich@buffalo.edu
RI Epstein, Leonard/AAE-5619-2021
OI Roemmich, James/0000-0002-6270-9678
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NR 65
TC 46
Z9 52
U1 0
U2 12
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1930-7381
EI 1930-739X
J9 OBESITY
JI Obesity
PD SEP
PY 2007
VL 15
IS 9
BP 2303
EP 2310
DI 10.1038/oby.2007.273
PG 8
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 219TK
UT WOS:000250110900017
PM 17890499
OA Bronze
DA 2025-06-11
ER

PT J
AU Wiley, JF
   Carrington, MJ
AF Wiley, Joshua F.
   Carrington, Melinda J.
TI A metabolic syndrome severity score: A tool to quantify cardio-metabolic
   risk factors
SO PREVENTIVE MEDICINE
LA English
DT Article
DE Metabolic syndrome; Risk factors; Cardiovascular disease; Diabetes
ID CONFIRMATORY FACTOR-ANALYSIS; CORONARY-HEART-DISEASE; CARDIOVASCULAR
   RISK; AUSTRALIAN ADULTS; HEALTHY HEARTS; PREVALENCE; NEIGHBORHOOD;
   VALIDATION; PROGRAM
AB Metabolic syndrome is a cluster of cardio-metabolic risk factors and is associated with increased mortality. There is no standard, validated way to assess the severity of aggregated metabolic syndrome risk factors.
   Cardiovascular and diabetes risk factor data came from two studies conducted in Australia from 2006 to 2010 in adults aged 18 or above. In medication free adults, sex-specific clinical thresholds and Principal Component Analysis were used to develop a formula to calculate a metabolic syndrome severity score (MetSSS). These scores were compared to scores derived using the same process in subgroups by sex, age, medication status, and time. We also examined the MetSSS in relation to other known risk factors.
   In 2125 adults (57.6 +/- 14.7 years of age), the MetSSS ranged from 0 to 8.7 with a mean of 2.6. There were strong correlations (.95-.99) between the MetSSS in medication free adults and the MetSSS calculated from subgroups. MetSSS predicted medication initiation for hypertension, hyperlipidemia and hyperglycemia over six months (OR = 1.31, 95% CI [1.00-1.70], per MetSSS unit, p =.043). Lower education, medication prescription, history of smoking and age were associated with higher MetSSS (all p < .05). Higher physical but not mental health quality of life was associated with lower MetSSS (p < .001).
   A standardized formula to measure cardio-metabolic risk factor severity was constructed and demonstrated expected relations with known risk factors. The use of the MetSSS is recommended as a measure of change within individuals in cardio-metabolic risk factors and to guide treatment and management. (C) 2016 Elsevier Inc. All rights reserved.
C1 [Wiley, Joshua F.; Carrington, Melinda J.] Australian Catholic Univ, Mary MacKillop Inst Hlth Res, Ctr Primary Care & Prevent, Melbourne, Vic, Australia.
C3 Australian Catholic University
RP Carrington, MJ (corresponding author), Australian Catholic Univ, Mary MacKillop Inst Hlth Res, Ctr Primary Care & Prevent, Melbourne, Vic, Australia.
EM melinda.carrington@acu.edu.au
RI Wiley, Joshua/I-6058-2019
OI Wiley, Joshua/0000-0002-0271-6702
CR Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
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NR 19
TC 62
Z9 65
U1 3
U2 20
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0091-7435
EI 1096-0260
J9 PREV MED
JI Prev. Med.
PD JUL
PY 2016
VL 88
BP 189
EP 195
DI 10.1016/j.ypmed.2016.04.006
PG 7
WC Public, Environmental & Occupational Health; Medicine, General &
   Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health; General & Internal Medicine
GA DQ2IB
UT WOS:000379024900026
PM 27095322
DA 2025-06-11
ER

PT J
AU Andaku, DK
   D'Almeida, V
   Carneiro, G
   Hix, S
   Tufik, S
   Togeiro, SM
AF Andaku, Daniela Kuguimoto
   D'Almeida, Vania
   Carneiro, Glaucia
   Hix, Sonia
   Tufik, Sergio
   Togeiro, Sonia Maria
TI Sleepiness, inflammation and oxidative stress markers in middle-aged
   males with obstructive sleep apnea without metabolic syndrome: a
   cross-sectional study
SO RESPIRATORY RESEARCH
LA English
DT Article
DE Obstructive sleep apnea; Excessive daytime sleepiness; Metabolic
   syndrome; Inflammation; C-reactive protein; Oxidative stress
ID C-REACTIVE PROTEIN; PLASMA TOTAL HOMOCYSTEINE; DAYTIME SLEEPINESS;
   INSULIN-RESISTANCE; CARDIOVASCULAR RISK; CYSTEINE; HYPERTENSION;
   ASSOCIATION; OBESITY; DISEASE
AB Background: The simultaneous occurrence of metabolic syndrome and excessive daytime sleepiness are very common in obstructive sleep apnea (OSA) patients. Both conditions, if present in OSA, have been reported to be associated with inflammation and disruption of oxidative stress balance that impair the cardiovascular system. To verify the impact of daytime sleepiness on inflammatory and oxidative stress markers, we evaluated OSA patients without significant metabolic disturbance.
   Methods: Thirty-five male subjects without diagnostic criteria for metabolic syndrome (Adult Treatment Panel III) were distributed into a control group (n = 10) (43 +/- 10.56 years, apnea-hypopnea index - AHI 2.71 +/- 1.48/hour), a non-sleepy OSA group (n = 11) (42.36 +/- 9.48 years, AHI 29.48 +/- 22.83/hour) and a sleepy OSA group (n = 14) (45.43 +/- 10.06 years, AHI 38.20 +/- 25.54/hour). Excessive daytime sleepiness was considered when Epworth sleepiness scale score was >= 10. Levels of high-sensitivity C-reactive protein, homocysteine and cysteine, and paraoxonase-1 activity and arylesterase activity of paraoxonase-1 were evaluated.
   Results: Patients with OSA and excessive daytime sleepiness presented increased high-sensitivity C-reactive protein levels even after controlling for confounders. No significant differences were found among the groups in paraoxonase-1 activity nor arylesterase activity of paraoxonase-1. AHI was independently associated and excessive daytime sleepiness tended to have an association with high-sensitivity C-reactive protein.
   Conclusions: In the absence of metabolic syndrome, increased inflammatory response was associated with AHI and daytime sleepiness, while OSA was not associated with abnormalities in oxidative stress markers.
C1 [Andaku, Daniela Kuguimoto; D'Almeida, Vania; Hix, Sonia; Tufik, Sergio; Togeiro, Sonia Maria] Univ Fed Sao Paulo UNIFESP EPM, Dept Psychobiol, Sao Paulo, Brazil.
   [Carneiro, Glaucia] Univ Fed Sao Paulo UNIFESP EPM, Dept Med, Sao Paulo, Brazil.
   [Hix, Sonia] Fac Med ABC FUABC, Dept Morphol & Physiol, Santo Andre, SP, Brazil.
C3 Universidade Federal de Sao Paulo (UNIFESP); Universidade Federal de Sao
   Paulo (UNIFESP); Faculdade de Medicina do ABC
RP D'Almeida, V (corresponding author), Univ Fed Sao Paulo UNIFESP EPM, Dept Psychobiol, Sao Paulo, Brazil.
EM vaniadalmeida@uol.com.br
RI Carneiro, Glaucia/U-7867-2017; Tufik, Sergio/D-7606-2012; D'Almeida,
   Vania/AAB-7115-2020; Hix, Sonia/O-2864-2017
OI D'Almeida, Vania/0000-0003-0947-5312; Togeiro, Sonia
   Maria/0000-0001-7103-9007; Hix, Sonia/0000-0002-6787-3557
FU FAPESP, Brazil [98/14303-3]; CNPq [501343/2010-5]; Associacao Fundo de
   Incentivo a Pesquisa (AFIP); Fundacao de Amparo a Pesquisa do Estado de
   Sao Paulo (FAPESP) [98/14303-3] Funding Source: FAPESP
FX This work was supported by grants from FAPESP, Brazil (CEPID
   #98/14303-3), CNPq and Associacao Fundo de Incentivo a Pesquisa (AFIP).
   V. D'Almeida and S. Tufik receive fellowships from CNPq. We also thank
   CNPq for our technical staff fellowship (#501343/2010-5). We are
   grateful to Vanessa Cavalcante, Bruno Calegare and Priscila Tamanaha for
   their helpful assistance during the biochemical analysis and to Prof.
   Dr. Altay Lino de Souza and Luciana Oliveira for their contribution to
   the statistical analysis.
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NR 43
TC 38
Z9 41
U1 0
U2 10
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1465-993X
J9 RESP RES
JI Respir. Res.
PD JAN 14
PY 2015
VL 16
AR 3
DI 10.1186/s12931-015-0166-x
PG 6
WC Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Respiratory System
GA AZ9RF
UT WOS:000348551000001
PM 25586501
OA gold, Green Published
DA 2025-06-11
ER

PT S
AU Pasquali, R
   Vicennati, V
   Cacciari, M
   Pagotto, U
AF Pasquali, Renato
   Vicennati, Valentina
   Cacciari, Mauro
   Pagotto, Uberto
BE Chrousos, GP
   Tsigos, C
TI The hypothalamic-pituitary-adrenal axis activity in obesity and the
   metabolic syndrome
SO STRESS, OBESITY, AND METABOLIC SYNDROME
SE Annals of the New York Academy of Sciences
LA English
DT Article; Proceedings Paper
CT Bjorntorp Symposium on Stress, Obesity, and Metabolic Syndrome
CY APR 09-10, 2005
CL Athens, GREECE
SP Roche Hellas, Abbott Hellas, Pfizer Hellas, Sanofi Aventis Hellas, GlaxoSmithKline Hellas
DE obesity; hypothalamic-pituitary-adrenal axis; glucocorticoids
ID BODY-FAT DISTRIBUTION; CORTICOTROPIN-RELEASING HORMONE; URINARY FREE
   CORTISOL; ABDOMINAL OBESITY; ADRENOCORTICAL AXIS; INSULIN-RESISTANCE;
   ADIPOSE-TISSUE; ALPRAZOLAM; SECRETION; STRESS
AB A hypothetical role of glucocorticoids in human obesity has been suggested since the abdominal obesity phenotype and syndromes of endogenous or exogenous hypercortisolism share several clinical, metabolic, and cardiovascular similarities. An emerging body of evidence indicates that both neuroendocrine dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis as well as peripheral alterations of cortisol metabolism may play a role in the pathophysiology of abdominal obesity. Major alterations of the HPA axis in vivo may be identified in different ways. They include evaluation of hormone concentrations: (a) in basal conditions, in blood, urine, or saliva samples; (b) during dynamic studies following stimulation with different neuropeptides or psychological stress challenges, or suppression with inhibiting agents of the HPA axis at different levels; and (c) after mixed meals or meals containing different nutrient compositions. In addition, alteration of peripheral cortisol metabolism can be detected by direct measurement of cortisol metabolites in urine, although this is a matter of more complex investigation. Alterations of the HPA axis in abdominal obesity are associated with insulin resistance, which suggests a direct responsibility of these hormonal alterations in the susceptibility of affected patients to develop both metabolic and cardiovascular diseases. According to available data, no single marker probably has the power to detect subtle alterations of the HPA axis in conditions, such as the abdominal obesity and the metabolic syndrome. On the contrary, they indicate the need for multiple parameters. At present, evaluation of urinary free cortisol, particularly during the night-time, and salivary-free cortisol appear to be promising for these purposes, whereas dynamic tests should be reserved for specific clinical settings, involving well-characterized patients.
C1 Univ Bologna, S Orsola Malpighi Hosp, Dept Internal Med, Div Endocrinol, I-40138 Bologna, Italy.
   Univ Bologna, S Orsola Malpighi Hosp, Ctr Appl Biomed Res, I-40138 Bologna, Italy.
C3 IRCCS Azienda Ospedaliero-Universitaria di Bologna; University of
   Bologna; University of Bologna; IRCCS Azienda Ospedaliero-Universitaria
   di Bologna
RP Pasquali, R (corresponding author), Univ Bologna, S Orsola Malpighi Hosp, Dept Internal Med, Div Endocrinol, Viai Massarenti 9, I-40138 Bologna, Italy.
EM renato.pasquali@unibo.it
RI Vicennati, Valentina/AAB-3291-2022
OI Vicennati, Valentina/0000-0002-0026-137X
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NR 49
TC 260
Z9 301
U1 0
U2 19
PU BLACKWELL SCIENCE PUBL
PI OXFORD
PA OSNEY MEAD, OXFORD OX2 0EL, ENGLAND
SN 0077-8923
BN 978-1-57331-625-5
J9 ANN NY ACAD SCI
JI Ann.NY Acad.Sci.
PY 2006
VL 1083
BP 111
EP 128
DI 10.1196/annals.1367.009
PG 18
WC Endocrinology & Metabolism; Multidisciplinary Sciences
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Science & Technology - Other Topics
GA BFR90
UT WOS:000244102900009
PM 17148736
DA 2025-06-11
ER

PT J
AU Rytz, CL
   Pialoux, V
   Mura, M
   Martin, A
   Hogan, DB
   Hill, MD
   Poulin, MJ
AF Rytz, Chantal L.
   Pialoux, Vincent
   Mura, Mathilde
   Martin, Agnes
   Hogan, David B.
   Hill, Michael D.
   Poulin, Marc J.
TI Impact of aerobic exercise, sex, and metabolic syndrome on markers of
   oxidative stress: results from the Brain in Motion study
SO JOURNAL OF APPLIED PHYSIOLOGY
LA English
DT Article
DE aging; antioxidant status; exercise; metabolic syndrome; oxidative
   stress
ID URIC-ACID; MEN; GENDER; WOMEN; INFLAMMATION; NEUTROPHILS; CAPACITY;
   DISEASE; ADULTS; ASSAY
AB Oxidative stress may be involved in disease pathology and dependent on both modifiable and nonmodifiable factors. This study aimed to assess exercise-induced changes in markers of oxidative stress among older, sedentary adults and to determine the effects of metabolic syndrome (MetS) status, aerobic capacity, age. sex, and weight on these biomarkers. Two hundred and six participants (means +/- SE; 66.8 +/- 6.4 yr, 104 women) of the Brain in Motion study underwent a 6-mo aerobic exercise intervention. At three time points, venous blood samples were collected and analyzed for markers of oxidative stress [advanced oxidation protein products (AOPP), malondialdehyde (MDA), 3-nitrotyrosine (3-NT) and antioxidant status: catalase, uric acid (UA), superoxide dismutase (SOD), and ferric-reducing ability of plasma (FRAP)]. AOPP levels significantly decreased after 6 mo of aerobic exercise (P = 0.003). This decrease was not modified by MetS status (P = 0.183). Subjects with MetS possessed significantly higher levels of AOPP (P < 0.001), MDA (P = 0.004), and FRAP (P = 0.049) across the intervention (months 0-6). Men possessed significantly higher levels of FRAP (P < 0.001), catalase (P = 0.023), and UA (P = 0.037) across the intervention (months 0-6). Sex-MetS status interaction analyses revealed that the effect of MetS is highly sex dependent. These findings are multifaceted because the effect of MetS status seems distinctly different between sexes, pointing to the importance of acknowledging modifiable and nonmodifiable factor differences in individuals who possess conditions where oxidative stress may be part of the etiology.
   NEW & NOTEWORTHY Oxidative stress is implicated in a myriad of conditions, namely cardiovascular disease risk factors. This article details the effect of aerobic exercise, sex, and metabolic syndrome on markers of oxidative stress. We conclude that 6 mo of aerobic exercise significantly decreased oxidative stress, and further, that there is an effect of metabolic syndrome status on oxidative stress and antioxidant status levels, which are highly dependent on the sex of the individual.
C1 [Rytz, Chantal L.; Poulin, Marc J.] Univ Calgary, Cumming Sch Med, Dept Physiol & Pharmacol, Heritage Med Res Bldg,Rm 210,3330 Hosp Dr NW, Calgary, AB T2N 4N1, Canada.
   [Rytz, Chantal L.; Poulin, Marc J.] Univ Calgary, Cumming Sch Med, Libin Cardiovasc Inst Alberta, Calgary, AB, Canada.
   [Pialoux, Vincent; Mura, Mathilde; Martin, Agnes] Univ Claude Bernard Lyon 1, Univ Lyon, Lab Interuniv Biol Motricite EA 7424, Villeurbanne, France.
   [Pialoux, Vincent] Inst Univ France, Paris, France.
   [Pialoux, Vincent] Lab Excellence GR Ex, Paris, France.
   [Hogan, David B.] Univ Calgary, Cumming Sch Med, Dept Med, Calgary, AB, Canada.
   [Rytz, Chantal L.; Hogan, David B.; Hill, Michael D.; Poulin, Marc J.] Univ Calgary, Cumming Sch Med, Hotchkiss Brain Inst, Calgary, AB, Canada.
   [Hill, Michael D.; Poulin, Marc J.] Univ Calgary, Cununing Sch Med, Dept Clin Neurosci, Calgary, AB, Canada.
   [Hill, Michael D.] Univ Calgary, Cumming Sch Med, Dept Conunun Hlth Sci, Calgary, AB, Canada.
   [Poulin, Marc J.] Univ Calgary, Fac Kinesiol, Calgary, AB, Canada.
C3 University of Calgary; University of Calgary; Libin Cardiovascular
   Institute Of Alberta; Universite Claude Bernard Lyon 1; Institut
   Universitaire de France; Institut National de la Sante et de la
   Recherche Medicale (Inserm); University of Calgary; University of
   Calgary; University of Calgary; University of Calgary; University of
   Calgary
RP Poulin, MJ (corresponding author), Univ Calgary, Cumming Sch Med, Dept Physiol & Pharmacol, Heritage Med Res Bldg,Rm 210,3330 Hosp Dr NW, Calgary, AB T2N 4N1, Canada.
EM poulin@ucalgary.ca
RI Poulin, Marc/JOZ-4665-2023; MURA, Mathilde/LPQ-2566-2024; Hill,
   Michael/C-9073-2012; Hogan, David/I-4360-2013
OI Rytz, Chantal/0000-0001-5174-6708; Hill, Michael/0000-0002-6269-1543;
   Hogan, David/0000-0002-9462-5460; Poulin, Marc/0000-0002-1798-6801;
   Mura, Mathilde/0000-0003-3010-1788
FU Canadian Institutes of Health Research Grant
   [200809MOP-192333-BCA-CBBA-41089]; Brenda Strafford Foundation Chair in
   Alzheimer Research (BSFCAR); BSFCAR; Queen Elizabeth II Graduate
   Scholarship; Alberta Graduate Student Scholarship; Eldon and Sheila
   Smith Graduate Scholarship in Cardiovascular Research; Institut
   Universitaire de France; Mitacs Globalink Research Award
FX The Brain in Motion study was supported by Canadian Institutes of Health
   Research Grant 200809MOP-192333-BCA-CBBA-41089 and by the Brenda
   Strafford Foundation Chair in Alzheimer Research (BSFCAR). C. L. Rytz is
   supported by BSFCAR, Mitacs Globalink Research Award, Queen Elizabeth II
   Graduate Scholarship, Alberta Graduate Student Scholarship, and the
   Eldon and Sheila Smith Graduate Scholarship in Cardiovascular Research.
   M. J. Poulin holds the BSFCAR. M. Mura and A. Martin were supported by
   the Institut Universitaire de France.
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NR 50
TC 14
Z9 17
U1 0
U2 3
PU AMER PHYSIOLOGICAL SOC
PI Rockville
PA 6120 Executive Blvd, Suite 600, Rockville, MD, UNITED STATES
SN 8750-7587
EI 1522-1601
J9 J APPL PHYSIOL
JI J. Appl. Physiol.
PD APR
PY 2020
VL 128
IS 4
BP 748
EP 756
DI 10.1152/japplphysiol.00667.2019
PG 9
WC Physiology; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology; Sport Sciences
GA LG8CP
UT WOS:000528322200004
PM 32105521
DA 2025-06-11
ER

PT J
AU Nishihara, M
   Hirooka, Y
   Sunagawa, K
AF Nishihara, Masaaki
   Hirooka, Yoshitaka
   Sunagawa, Kenji
TI Combining irbesartan and trichlormethiazide enhances blood pressure
   reduction via inhibition of sympathetic activity without adverse effects
   on metabolism in hypertensive rats with metabolic syndrome
SO CLINICAL AND EXPERIMENTAL HYPERTENSION
LA English
DT Article
DE Angiotensin II receptor blocker; combination therapy; diuretics;
   hypertension; metabolic syndrome; sympathetic activity
ID ROSTRAL VENTROLATERAL MEDULLA; RENIN-ANGIOTENSIN SYSTEM; OXIDATIVE
   STRESS; CARDIOVASCULAR REGULATION; RECEPTOR BLOCKADE; NERVE ACTIVITY;
   BRAIN; OBESITY; SYMPATHOEXCITATION; TELMISARTAN
AB Sympathoexcitation and oxidative stress in the brain have pivotal roles in hypertension with metabolic syndrome (MetS). Here, we examined whether oral administration of irbesartan (IRB) and trichlormethiazide (TCM) decreases blood pressure (BP) via inhibiting sympathetic activity through anti-oxidant effects in the brain of spontaneously hypertensive rats (SHR-cp). IRB/TCM treatment decreased BP more profoundly than IRB monotherapy. Urinary norepinephrine excretion and oxidative stress in the brain were decreased in both IRB and IRB/TCM groups without any adverse effect on the metabolic profile. These findings suggest that IRB/TCM profoundly decreases BP in SHR-cp by inhibiting sympathetic activity via anti-oxidant effects in the brain.
C1 [Nishihara, Masaaki; Sunagawa, Kenji] Kyushu Univ, Grad Sch Med Sci, Dept Cardiovasc Med, Fukuoka 8128582, Japan.
   [Hirooka, Yoshitaka] Kyushu Univ, Grad Sch Med Sci, Dept Adv Cardiovasc Regulat & Therapeut, Fukuoka 8128582, Japan.
C3 Kyushu University; Kyushu University
RP Hirooka, Y (corresponding author), Kyushu Univ, Grad Sch Med Sci, Dept Adv Cardiovasc Regulat, Higashi Ku, 3-1-1 Maidashi, Fukuoka 8128582, Japan.
EM hyoshi@cardiol.med.kyushu-u.ac.jp
FU Shionogi Co., Ltd.; Grants-in-Aid for Scientific Research [24390198]
   Funding Source: KAKEN
FX This study was supported by a grant from Shionogi & Co., Ltd. The
   authors alone are responsible for the content and writing of the paper.
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NR 38
TC 3
Z9 3
U1 0
U2 1
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1064-1963
EI 1525-6006
J9 CLIN EXP HYPERTENS
JI Clin. Exp. Hypertens.
PY 2015
VL 37
IS 1
BP 33
EP 38
DI 10.3109/10641963.2014.897719
PG 6
WC Pharmacology & Pharmacy; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Cardiovascular System & Cardiology
GA AZ1EF
UT WOS:000347982300006
PM 24678944
DA 2025-06-11
ER

PT J
AU Saygin, H
   Tosun, M
   Öztürk, A
   Ergin, IE
   Kiraç, E
   Asdemir, A
   Velibeyoglu, AF
   Aktas, A
   Korgali, E
AF Saygin, Huseyin
   Tosun, Mustafa
   Ozturk, Abuzer
   Ergin, Ismail Emre
   Kirac, Emre
   Asdemir, Aydemir
   Velibeyoglu, Arslan Fatih
   Aktas, Ahmet
   Korgali, Esat
TI Effects of psoriasis and metabolic syndrome on male sexual functions
SO JOURNAL OF MENS HEALTH
LA English
DT Article
DE Psoriasis; Erectile dysfunction; Metabolic syndrome
ID ERECTILE DYSFUNCTION; HEALTH
AB Background and Objective: Psoriasis is a chronic inflammatory systemic skin disease triggered by psychological, genetic and environmental factors. The effect of psoriasis on sexual health has not been fully elucidated. Coexistence of psychiatric disorders also affects negatively the life quality of psoriasis patients. This study investigates the relationship between the severity of the current illness, psychosocial health problems and coexisting metabolic syndrome on sexual health in male patients with psoriasis.
   Materials and methods: 52 male patients diagnosed with psoriasis and 50 healthy men included for the study. Patient groups Psoriasis Area Severity Index (PASI) and The Dermatology Life Quality Index (DLQI) were tested, subsequently International Index of Erectile Function (IIEF), Hamilton Rating Scale for Depression (HAM-D) tests and Metabolic syndrome (MetS) were reported for both groups. Eventually, the patient groups treaments were recorded.
   Results: IIEF, HAM-D scores and MetS were significantly different between the two groups (P = 0.017, P = 0.005, P = 0.009). IIEF score had a significant negative correlation with age, HAM-D and PASI scores (r = -0.405, -0.217 and -0.394, P = 0.028, 0.043 and 0.014). It is seen that the frequency and severity of ED increased with methotrexate treatment.
   Conclusion: It is showed that psoriasis has negative effects on male sexual health in this study. Our opinion of the reason is the natural course of the disease, its coexistence with diseases such as metabolic syndrome and depression, and the agents used in its treatment.
C1 [Saygin, Huseyin; Ozturk, Abuzer; Ergin, Ismail Emre; Kirac, Emre; Asdemir, Aydemir; Velibeyoglu, Arslan Fatih; Korgali, Esat] Cumhuriyet Univ, Fac Med, Dept Urol, TR-41400 Sivas, Turkey.
   [Tosun, Mustafa] Cumhuriyet Univ, Fac Med, Dept Dermatol, TR-41400 Sivas, Turkey.
   [Aktas, Ahmet] Cumhuriyet Univ, Fac Med, Dept Internal Med, TR-41400 Sivas, Turkey.
C3 Cumhuriyet University; Cumhuriyet University; Cumhuriyet University
RP Aktas, A (corresponding author), Cumhuriyet Univ, Fac Med, Dept Internal Med, TR-41400 Sivas, Turkey.
EM ahmetaktas0142@hotmail.com
RI Korgali, Esat/AAM-1055-2020; Asdemir, Aydemir/LXB-0245-2024; Tosun,
   Mustafa/JJF-7937-2023
OI Velibeyoglu, Arslan Fatih/0000-0001-7139-4834; Tosun,
   Mustafa/0000-0002-6189-8016
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NR 18
TC 2
Z9 2
U1 0
U2 9
PU IMR PRESS
PI ROBINSON
PA 112 ROBINSON RD, ROBINSON, SINGAPORE
SN 1875-6867
EI 1875-6859
J9 J MENS HEALTH
JI J. Mens Health
PY 2021
VL 17
IS 3
BP 91
EP 95
DI 10.31083/jomh.2021.038
PG 5
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA TI4XI
UT WOS:000672805400013
OA Bronze
DA 2025-06-11
ER

PT J
AU Raut, SK
   Khullar, M
AF Raut, Satish K.
   Khullar, Madhu
TI Oxidative stress in metabolic diseases: current scenario and therapeutic
   relevance
SO MOLECULAR AND CELLULAR BIOCHEMISTRY
LA English
DT Article
DE ROS; Metabolic disease; Oxidative stress; Gut microbiota; Free radicals
ID PROTEIN-KINASE-C; INSULIN-RESISTANCE; MOLECULAR-MECHANISMS; DEPENDENT
   ACTIVATION; POLYOL PATHWAY; POTENTIAL ROLE; MITOCHONDRIA; ANTIOXIDANTS;
   INFLAMMATION; PATHOGENESIS
AB The metabolic syndrome is a clustering condition of increased abdominal obesity in concert with hyperglycemia, insulin resistance, hypertension, and dyslipidemia. It confers higher risk of metabolic diseases such as diabetes and ischemic heart disease and has been observed to be associated with high morbidity and mortality. It is a progressive pathological process for diabetes-induced complications and appears to be multifactorial in origin. Several preclinical, clinical, and epidemiological reports have shown a persistent link between the metabolic syndrome and oxidative stress. There is pronounced imbalance between pro-oxidants and anti-oxidants with increased production of oxidizing molecules, depletion of anti-oxidants, and consequently accumulation of protein and lipid oxidation products in the cell in metabolic syndrome. The increased cellular pro-oxidant activity also results in altered molecular pathways, mitochondrial dysfunction, deregulation in cell cycle control, chromosomal aberrations, inflammation, and overall decreased biological activity as well as impairment of the antioxidant systems. Here, the focus of our review article will be on the formation of oxidative species, the interplay between metabolic syndrome and oxidative stress, and its potential implications in therapeutic approaches.
C1 [Raut, Satish K.] Dr DY Patil Vidyapeeth, Dr DY Patil Biotechnol & Bioinformat Inst, Genet & Mol Biol Res Lab, Pune 411033, Maharashtra, India.
   [Khullar, Madhu] PGIMER, Expt Med & Biotechnol, ICMR, Chandigarh 160012, India.
C3 Dr DY Patil Vidyapeeth Pune; Dr D Y Patil Biotechnology & Bioinformatics
   Institute; Post Graduate Institute of Medical Education & Research
   (PGIMER), Chandigarh; Indian Council of Medical Research (ICMR)
RP Khullar, M (corresponding author), PGIMER, Expt Med & Biotechnol, ICMR, Chandigarh 160012, India.
EM madhu.khullar@gmail.com
RI Raut, Satish/AAP-2262-2021
OI Khullar, Madhu/0000-0003-4461-2466
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NR 103
TC 58
Z9 59
U1 1
U2 18
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0300-8177
EI 1573-4919
J9 MOL CELL BIOCHEM
JI Mol. Cell. Biochem.
PD JAN
PY 2023
VL 478
IS 1
BP 185
EP 196
DI 10.1007/s11010-022-04496-z
EA JUN 2022
PG 12
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA 7W5KD
UT WOS:000817964700002
PM 35764861
DA 2025-06-11
ER

PT J
AU Fan, CN
   Zirpoli, H
   Qi, KM
AF Fan, Chaonan
   Zirpoli, Hylde
   Qi, Kemin
TI n-3 fatty acids modulate adipose tissue inflammation and oxidative
   stress
SO CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE
LA English
DT Review
DE adipose tissue; inflammation; metabolic syndrome; n-3 fatty acids;
   oxidative stress
ID IMPROVES INSULIN SENSITIVITY; METABOLIC SYNDROME; DOCOSAHEXAENOIC ACID;
   FISH-OIL; MACROPHAGE ACCUMULATION; GENE-EXPRESSION; NADPH OXIDASE;
   OBESITY; RESISTANCE; ADIPONECTIN
AB Purpose of review
   Dietary n-3 polyunsaturated fatty acids (n-3 PUFAs) may be related to a number of chronic metabolic abnormalities, including metabolic syndrome. This review presents an update on the effects of n-3 PUFAs on risk factors of metabolic syndrome, especially adipose tissue inflammation, oxidative stress and underlying mechanisms of these effects.
   Recent findings
   Anti-inflammatory actions of n-3 PUFAs are thought to be mediated by the formation of their active metabolites (eicosanoids and other lipid mediators) as well as their regulation of the production of inflammatory mediators (e.g., adipocytokines, cytokines) and immune cell infiltration into adipose tissue. n-3 PUFAs mediate these effects by modulating several pathways, such as those involving nuclear factor-kappa B, peroxisome proliferator-activated receptors and Toll-like receptors. The antioxidative effects of n-3 PUFAs in adipocytes appear to inhibit reactive oxygen species production and alter mitochondrial function.
   Summary
   This review summarizes the evidence for beneficial effects of n-3 PUFAs on adipose tissue inflammation and oxidative stress. More studies are necessary to investigate the mechanisms underlying these effects and to relate this topic to human health.
C1 [Fan, Chaonan; Qi, Kemin] Capital Med Univ, Beijing Childrens Hosp, Beijing Pediat Res Inst, Minist Educ,Key Lab Major Dis Children, Beijing 100045, Peoples R China.
   [Fan, Chaonan; Qi, Kemin] Capital Med Univ, Beijing Childrens Hosp, Beijing Pediat Res Inst, Minist Educ,Natl Key Discipline Pediat, Beijing, Peoples R China.
   [Zirpoli, Hylde] Columbia Univ Coll Phys & Surg, Inst Human Nutr, New York, NY 10032 USA.
C3 Capital Medical University; Ministry of Education - China; Ministry of
   Education - China; Capital Medical University; Columbia University
RP Qi, KM (corresponding author), Capital Med Univ, Beijing Childrens Hosp, Beijing Pediat Res Inst, 56 Nan Lishi Rd, Beijing 100045, Peoples R China.
EM qkm6@hotmail.com
OI Qi, Kemin/0000-0002-4887-8598
FU Funds for High-Level Technical Talents in the Beijing Health System
   [2009-3-40]
FX The authors wish to acknowledge Dr Richard J. Deckelbaum, Columbia
   University, New York, New York, for his review of this manuscript. The
   work of the authors was supported by Funds for High-Level Technical
   Talents in the Beijing Health System (Discipline Backbone 2009-3-40)
   (K.Q).
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SN 1363-1950
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JI Curr. Opin. Clin. Nutr. Metab. Care
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BP 124
EP 132
DI 10.1097/MCO.0b013e32835c02c8
PG 9
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 088BT
UT WOS:000314809500002
PM 23222801
DA 2025-06-11
ER

PT J
AU Curtis, J
   Henry, C
   Watkins, A
   Newall, H
   Samaras, K
   Ward, PB
AF Curtis, Jackie
   Henry, Catherine
   Watkins, Andrew
   Newall, Hannah
   Samaras, Katherine
   Ward, Philip B.
TI Metabolic abnormalities in an early psychosis service: a retrospective,
   naturalistic cross-sectional study
SO EARLY INTERVENTION IN PSYCHIATRY
LA English
DT Article
DE antipsychotic-monitoring; first-episode psychosis; metabolic syndrome
ID DRUG-NAIVE PATIENTS; RANDOMIZED CLINICAL-TRIAL; INDUCED WEIGHT-GAIN;
   1ST-EPISODE PSYCHOSIS; DOUBLE-BLIND; ANTIPSYCHOTIC TREATMENT;
   GLUCOSE-TOLERANCE; SCHIZOPHRENIA; PREDICTORS; OLANZAPINE
AB Aim: There is an increasing recognition of the impact of weight gain on the development of metabolic abnormalities in young people receiving atypical antipsychotic drugs for first-episode psychosis. This study examined the prevalence of such abnormalities in a specialist early-intervention community mental health team.
   Methods: A retrospective case record audit of 85 patients 16-27 years old attending the Early Psychosis Service between October 2006 and June 2008, who had at least one metabolic measure defined as: weight, body mass index (BMI), waist circumference, blood pressure, and fasting blood glucose and lipids. Metabolic syndrome identified by the International Diabetes Federation (IDF) criteria.
   Results: Fifty-five percent of males and 42% of females were overweight or obese at a median treatment duration of 8 months. Duration of antipsychotic therapy was associated with higher BMI (r = 0.28, P < 0.01). More than 40% of the total sample had high waist circumference. Of the 64 subjects with complete metabolic data, eight (12.5%) met full IDF criteria for metabolic syndrome, and another 21 (32.8%) had either increased waist with one metabolic abnormality or normal waist and two metabolic abnormalities.
   Conclusion: Over a third of young patients being treated for their first episode of psychosis either had metabolic syndrome or showed metabolic abnormalities. Treatment duration related to higher BMI and greater prevalence of metabolic syndrome. Detection of metabolic complications after treatment instigation in patients with first-episode psychosis will permit early intervention with lifestyle or drug interventions in those at risk of significant physical health morbidity.
C1 [Curtis, Jackie; Henry, Catherine; Watkins, Andrew] Univ New S Wales, Early Psychosis Programme, Bondi Ctr, S Eastern Sydney Local Hlth Network, Sydney, NSW 2052, Australia.
   [Curtis, Jackie; Ward, Philip B.] Univ New S Wales, Sch Psychiat, Sydney, NSW 2052, Australia.
   [Newall, Hannah] Univ New S Wales, Fac Med, Schizophrenia Res Unit, Sydney, NSW 2052, Australia.
   [Samaras, Katherine] St Vincents Hosp, Dept Endocrinol, Sydney, NSW 2010, Australia.
   [Samaras, Katherine] Garvan Inst Med Res, Diabet Program, Sydney, NSW, Australia.
   [Ward, Philip B.] Sydney SW Local Hlth Network, Schizophrenia Res Unit, Sydney, NSW, Australia.
C3 University of New South Wales Sydney; University of New South Wales
   Sydney; University of New South Wales Sydney; NSW Health; St Vincents
   Hospital Sydney; Garvan Institute of Medical Research
RP Curtis, J (corresponding author), 26 Llandaff St, Bondi Jct, NSW 2022, Australia.
EM jackie.curtis@sesiahs.health.nsw.gov.au
RI Curtis, Jackie/J-5789-2019; Ward, Philip/JCE-6293-2023
OI Myles, Hannah/0000-0003-3411-5693; Curtis, Jackie/0000-0001-6884-0098;
   Watkins, Andrew/0000-0003-3452-8682; Ward, Philip/0000-0002-5779-7722
CR Addington J, 2003, CAN J PSYCHIAT, V48, P272, DOI 10.1177/070674370304800412
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NR 35
TC 46
Z9 47
U1 0
U2 11
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1751-7885
EI 1751-7893
J9 EARLY INTERV PSYCHIA
JI Early Interv. Psychiatry
PD MAY
PY 2011
VL 5
IS 2
BP 108
EP 114
DI 10.1111/j.1751-7893.2011.00262.x
PG 7
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 755PR
UT WOS:000289947700004
PM 21470374
DA 2025-06-11
ER

PT J
AU Everett, BG
   Rosario, M
   McLaughlin, KA
   Austin, SB
AF Everett, Bethany G.
   Rosario, Margaret
   McLaughlin, Katie A.
   Austin, S. Bryn
TI Sexual Orientation and Gender Differences in Markers of Inflammation and
   Immune Functioning
SO ANNALS OF BEHAVIORAL MEDICINE
LA English
DT Article
DE Gender; Sexual orientation; Inflammation; Immune functioning; Stress
ID C-REACTIVE PROTEIN; EPSTEIN-BARR-VIRUS; HORMONE REPLACEMENT THERAPY;
   MENTAL-HEALTH; SUBSTANCE USE; BISEXUAL POPULATIONS; POSTTRAUMATIC
   STRESS; EMOTION REGULATION; METABOLIC SYNDROME; CHILDHOOD ABUSE
AB Sexual minorities have documented elevated risk factors that can lead to inflammation and poor immune functioning.
   This study aims to investigate disparities in C-reactive protein (CRP) and Epstein-Barr virus (EBV) by gender and sexual orientation.
   We used the National Longitudinal Study of Adolescent Health to examine disparities in CRP (N = 11,462) and EBV (N = 11,812).
   Among heterosexuals, women had higher levels of CRP and EBV than men. However, sexual minority men had higher levels of CRP and EBV than heterosexual men and sexual minority women. Lesbians had lower levels of CRP than heterosexual women.
   Gender differences in CRP and EBV found between men and women who identify as 100 % heterosexual were reversed among sexual minorities and not explained by known risk factors (e.g., victimization, alcohol and tobacco use, and body mass index). More nuanced approaches to addressing gender differences in sexual orientation health disparities that include measures of gender nonconformity and minority stress are needed.
C1 [Everett, Bethany G.] Univ Illinois, Dept Sociol, Chicago, IL 60607 USA.
   [Rosario, Margaret] CUNY City Coll, Dept Psychol, New York, NY 10031 USA.
   [Rosario, Margaret] CUNY, Grad Ctr, New York, NY USA.
   [McLaughlin, Katie A.] Univ Washington, Dept Psychol, Seattle, WA 98195 USA.
   [Austin, S. Bryn] Boston Childrens Hosp, Div Adolescent & Young Adult Med, Boston, MA USA.
   [Austin, S. Bryn] Harvard Univ, Sch Publ Hlth, Dept Social & Behav Sci, Boston, MA 02115 USA.
   [Austin, S. Bryn] Harvard Univ, Sch Med, Dept Pediat, Boston, MA 02115 USA.
C3 University of Illinois System; University of Illinois Chicago;
   University of Illinois Chicago Hospital; City University of New York
   (CUNY) System; City College of New York (CUNY); City University of New
   York (CUNY) System; University of Washington; University of Washington
   Seattle; Harvard University; Harvard University Medical Affiliates;
   Boston Children's Hospital; Harvard University; Harvard T.H. Chan School
   of Public Health; Harvard University; Harvard Medical School
RP Everett, BG (corresponding author), Univ Illinois, Dept Sociol, 4112 BSB,1007 W Harrison St, Chicago, IL 60607 USA.
EM everettb@uic.edu
RI McLaughlin, Katie/AGG-9349-2022
OI Everett, Bethany/0000-0001-5370-1909; McLaughlin,
   Katie/0000-0002-1362-2410
FU NICHD NIH HHS [K12HD055892, K12 HD055892, P2C HD066613, R01 HD066963,
   R03 HD062597, R24 HD066613] Funding Source: Medline; NIMH NIH HHS [K01
   MH092526] Funding Source: Medline
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NR 109
TC 30
Z9 43
U1 0
U2 32
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0883-6612
EI 1532-4796
J9 ANN BEHAV MED
JI Ann. Behav. Med.
PD FEB
PY 2014
VL 47
IS 1
BP 57
EP 70
DI 10.1007/s12160-013-9567-6
PG 14
WC Psychology, Multidisciplinary
WE Social Science Citation Index (SSCI)
SC Psychology
GA AB2TX
UT WOS:000331646100007
PM 24347405
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Kempel, MK
   Winding, TN
   Böttcher, M
   Hansen, SN
   Andersen, JH
AF Kempel, Mia Klinkvort
   Winding, Trine Nohr
   Bottcher, Morten
   Hansen, Stefan Nygaard
   Andersen, Johan Hviid
TI Childhood socioeconomic position and cardiometabolic risk in young
   adulthood- the impact of mental health
SO BMC PUBLIC HEALTH
LA English
DT Article
DE Social inequality; Psychological factors; Cardiometabolic diseases;
   Young adults; Epidemiology; Causal inference
ID CARDIOVASCULAR-DISEASE; PSYCHOSOCIAL FACTORS; MEDIATION ANALYSIS;
   ADOLESCENTS; CHILDREN; INEQUALITIES; BIOMARKERS; MORTALITY
AB BackgroundLow socioeconomic position in childhood is associated with greater cardiometabolic disease risk later in life. The aim of the current study is to examine the mediating impact of mental health on the association between childhood socioeconomic position and cardiometabolic disease risk in young adulthood.MethodsWe used a combination of national registers, longitudinal questionnaire-data and clinical measurements from a sub-sample (N = 259) of a Danish youth cohort. Childhood socioeconomic position was indicated by the educational level of the mother and the father at age 14. Mental health was measured by four different symptom scales at four age-points (age 15, 18, 21 and 28), and combined into one global score. Cardiometabolic disease risk was measured by nine biomarkers at age 28-30 and combined into one global score by sample-specific z-scores. We conducted analyses within the causal inference framework and evaluated the associations using nested counterfactuals.ResultsWe found an inverse association between childhood socioeconomic position and cardiometabolic disease risk in young adulthood. The proportion of the association which was mediated by mental health was 10 (95% CI: -4; 24) % and 12 (95% CI: -4; 28) % using educational level of the mother and the father as indicator, respectively.ConclusionsAccumulated poorer mental health in childhood, youth and early adulthood partially explained the association between low childhood socioeconomic position and increased cardiometabolic disease risk in young adulthood. The results of the causal inference analyses rely on the underlying assumptions and correct depiction of the DAG. Since these are not all testable, we cannot exclude violations that potentially could bias the estimates. If the findings can be replicated, this would support a causal relationship and direct potentials for intervention. However, the findings point to a potential for intervention in young age in order to impede the translation of childhood social stratification into later cardiometabolic disease risk disparities.
C1 [Kempel, Mia Klinkvort; Winding, Trine Nohr; Andersen, Johan Hviid] Univ Res Clin, Goedstrup Hosp, Danish Ramazzini Ctr, Dept Occupat Med, Herning, Denmark.
   [Bottcher, Morten] Univ Res Clin, Goedstrup Hosp, Dept Cardiol, Cardiovasc Res Unit, Herning, Denmark.
   [Hansen, Stefan Nygaard] Aarhus Univ, Dept Publ Hlth, Aarhus, Denmark.
   [Kempel, Mia Klinkvort; Winding, Trine Nohr; Bottcher, Morten; Andersen, Johan Hviid] Aarhus Univ, Fac Hlth, Dept Clin Med, Aarhus, Denmark.
   [Kempel, Mia Klinkvort] Gl Landevej 61, DK-7400 Herning, Denmark.
C3 Aarhus University; Aarhus University
RP Kempel, MK (corresponding author), Univ Res Clin, Goedstrup Hosp, Danish Ramazzini Ctr, Dept Occupat Med, Herning, Denmark.; Kempel, MK (corresponding author), Aarhus Univ, Fac Hlth, Dept Clin Med, Aarhus, Denmark.; Kempel, MK (corresponding author), Gl Landevej 61, DK-7400 Herning, Denmark.
EM mialaurs@rm.dk
RI Bottcher, M./AAI-8098-2020; Andersen, Johan/AAI-2086-2019
OI Hviid Andersen, Johan/0000-0003-1638-8276; Winding, Trine
   Nohr/0000-0002-2448-0403; Bottcher, Morten/0000-0002-2116-2370
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NR 53
TC 0
Z9 0
U1 1
U2 3
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2458
J9 BMC PUBLIC HEALTH
JI BMC Public Health
PD JUN 13
PY 2023
VL 23
IS 1
AR 1136
DI 10.1186/s12889-023-15942-y
PG 10
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA J4OW0
UT WOS:001009432100003
PM 37312084
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Chen, SW
   Wu, YQ
   Li, S
   Li, J
   Lang, XE
   Zhang, XY
AF Chen, Shi Wang
   Wu, Yan Qing
   Li, Shen
   Li, Jie
   Lang, Xiao E.
   Zhang, Xiang-Yang
TI Prevalence, risk factors and clinical correlates of glucose disturbances
   in a large sample of Han Chinese patients with first-episode drug-naive
   major depressive disorder
SO EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
LA English
DT Article
DE Major depressive disorder; Glucose disturbances; First-episode drug
   naive; Suicide attempt
ID BRAIN GLUCOSE; METABOLIC SYNDROME; ANIMAL-MODEL; SUICIDE; ASSOCIATION;
   METAANALYSIS; ADOLESCENTS; HISTORY; ANXIETY; IMPACT
AB Glucose disturbances are a common comorbidity of major depressive disorder (MDD) patients and have been extensively studied in the past. However, few studies have explored glucose disturbances in first-episode drug-naive (FEDN) MDD patients. The purpose of this study was to examine the prevalence and risk factors of glucose disturbances in FEDN MDD patients to understand the relationship between MDD and glucose disturbances in the acute early phase and provide important implications for therapeutic interventions. Using a cross-sectional design, we recruited a total of 1718 MDD patients. We collected their socio-demographic information, clinical data, and blood glucose indicators.17-item Hamilton Depression Rating Scale (HAMD), 14-item Hamilton Anxiety Rating Scale (HAMA), and the positive symptom subscale of the Positive and Negative Syndrome Scale (PANSS) were used to assess their depression, anxiety, psychotic symptoms, respectively. The prevalence of glucose disturbances in FEDN MDD patients was 13.6%. Depression, anxiety and psychotic symptoms, body mass index (BMI) levels and suicide attempts rates were higher in the group with glucose disorders than in the group without glucose disorders among patients with first-episode drug-naive MDD. Correlation analysis showed that glucose disturbances were associated with HAMD score, HAMA score, BMI, psychotic symptoms and suicide attempts. Furthermore, binary logistic regression showed that HAMD score and suicide attempts were independently associated with glucose disturbances in MDD patients. Our findings suggest that the prevalence of comorbid glucose disturbances is very high in FEDN MDD patients. Moreover, more severe depressive symptoms and higher suicide attempts are correlated with glucose disturbances in MDD FEDN patients in the early stage.
C1 [Chen, Shi Wang; Wu, Yan Qing; Li, Shen; Li, Jie] Tianjin Anding Hosp, Inst Mental Hlth, Tianjin, Peoples R China.
   [Lang, Xiao E.] Shanxi Med Univ, Hosp 1, Dept Psychiat, Taiyuan, Peoples R China.
   [Zhang, Xiang-Yang] Univ Chinese Acad Sci, Chinese Acad Sci, Dept Psychol, Inst Psychol, 16 Lincui Rd, Beijing, Peoples R China.
C3 Shanxi Medical University; Chinese Academy of Sciences; University of
   Chinese Academy of Sciences, CAS
RP Zhang, XY (corresponding author), Univ Chinese Acad Sci, Chinese Acad Sci, Dept Psychol, Inst Psychol, 16 Lincui Rd, Beijing, Peoples R China.
EM zhangxy@psych.ac.cn
RI Zhang, Xiangyang/ABC-7380-2022; Wu, Yanqing/R-7847-2019
OI Zhang, Xiangyang/0000-0003-3326-382X
FU CAS International Cooperation Research Program [153111KYSB20190004];
   Tianjin Key Medical Discipline (Specialty) Construction Project
   [TJYXZDXK-033A]
FX This study was supported by grants from the CAS International
   Cooperation Research Program (153111KYSB20190004) and funded by Tianjin
   Key Medical Discipline (Specialty) Construction Project (TJYXZDXK-033A).
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NR 48
TC 3
Z9 3
U1 1
U2 4
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0940-1334
EI 1433-8491
J9 EUR ARCH PSY CLIN N
JI Eur. Arch. Psych. Clin. Neurosci.
PD APR
PY 2024
VL 274
IS 3
BP 549
EP 557
DI 10.1007/s00406-023-01581-2
EA MAR 2023
PG 9
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Psychiatry
GA NB1P9
UT WOS:000945757700001
PM 36884047
DA 2025-06-11
ER

PT J
AU Berardelli, I
   Corigliano, V
   Hawkins, M
   Comparelli, A
   Erbuto, D
   Pompili, M
AF Berardelli, Isabella
   Corigliano, Valentina
   Hawkins, Michael
   Comparelli, Anna
   Erbuto, Denise
   Pompili, Maurizio
TI Lifestyle Interventions and Prevention of Suicide
SO FRONTIERS IN PSYCHIATRY
LA English
DT Review
DE suicide; suicide attempts; suicidal thoughts; lifestyle behavior;
   lifestyle intervention; suicide prevention
ID BODY-MASS INDEX; OLDER-ADULTS; MENTAL-HEALTH; PHYSICAL-ACTIVITY;
   SELF-ESTEEM; SPORTS PARTICIPATION; GENERAL-POPULATION; BIPOLAR DISORDER;
   RISK-FACTORS; IDEATION
AB Over the past years, there has been a growing interest in the association between lifestyle psychosocial interventions, severe mental illness, and suicide risk. Patients with severe mental disorders have higher mortality rates, poor health states, and higher suicide risk compared to the general population. Lifestyle behaviors are amenable to change through the adoption of specific psychosocial interventions, and several approaches have been promoted. The current article provides a comprehensive review of the literature on lifestyle interventions, mental health, and suicide risk in the general population and in patients with psychiatric disorders. For this purpose, we investigated lifestyle behaviors and lifestyle interventions in three different age groups: adolescents, young adults, and the elderly. Several lifestyle behaviors including cigarette smoking, alcohol use, and sedentary lifestyle are associated with suicide risk in all age groups. In adolescents, growing attention has emerged on the association between suicide risk and internet addiction, cyberbullying and scholastic and family difficulties. In adults, psychiatric symptoms, substance and alcohol abuse, weight, and occupational difficulties seems to have a significant role in suicide risk. Finally, in the elderly, the presence of an organic disease and poor social support are associated with an increased risk of suicide attempt. Several factors may explain the association between lifestyle behaviors and suicide. First, many studies have reported that some lifestyle behaviors and its consequences (sedentary lifestyle, cigarette smoking underweight, obesity) are associated with cardiometabolic risk factors and with poor mental health. Second, several lifestyle behaviors may encourage social isolation, limiting the development of social networks, and remove individuals from social interactions; increasing their risk of mental health problems and suicide.
C1 [Berardelli, Isabella; Corigliano, Valentina; Comparelli, Anna; Erbuto, Denise; Pompili, Maurizio] Sapienza Univ Rome, St Andrea Hosp, Dept Neurosci Mental Hlth & Sensory Organs, Suicide Prevent Ctr, Rome, Italy.
   [Hawkins, Michael] Univ Toronto, Dept Psychiat, Toronto, ON, Canada.
C3 Sapienza University Rome; Azienda Ospedaliera Sant'Andrea; University of
   Toronto
RP Pompili, M (corresponding author), Sapienza Univ Rome, St Andrea Hosp, Dept Neurosci Mental Hlth & Sensory Organs, Suicide Prevent Ctr, Rome, Italy.
EM maurizio.pompili@uniroma1.it
RI Berardelli, Isabella/A-5617-2019; Pompili, Maurizio/AAC-1011-2019
OI Comparelli, Anna/0000-0003-4557-0931
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NR 138
TC 44
Z9 46
U1 3
U2 73
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-0640
J9 FRONT PSYCHIATRY
JI Front. Psychiatry
PD NOV 6
PY 2018
VL 9
AR 567
DI 10.3389/fpsyt.2018.00567
PG 10
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA GZ3ZX
UT WOS:000449329900003
PM 30459660
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Chiang, JJ
   Park, H
   Almeida, DM
   Bower, JE
   Cole, SW
   Irwin, MR
   McCreath, H
   Seeman, TE
   Fuligni, AJ
AF Chiang, Jessica J.
   Park, Heejung
   Almeida, David M.
   Bower, Julienne E.
   Cole, Steve W.
   Irwin, Michael R.
   McCreath, Heather
   Seeman, Teresa E.
   Fuligni, Andrew J.
TI Psychosocial Stress and C-Reactive Protein From Mid-Adolescence to Young
   Adulthood
SO HEALTH PSYCHOLOGY
LA English
DT Article
DE inflammation; CRP; perceived stress; life events; daily stress
ID CHILDHOOD ADVERSITY; METABOLIC SYNDROME; PSYCHOLOGICAL STRESS;
   DEPRESSIVE SYMPTOMS; CARDIOVASCULAR RISK; NATIONAL-HEALTH; US
   ADOLESCENTS; LIFE EVENTS; FAT MASS; INFLAMMATION
AB Objective: Cardiovascular disease (CVD) is one of the most prevalent chronic conditions and leading causes of death. Although CVD clinically manifests in adulthood, underlying processes of CVD begin in the earlier decades of life. Inflammation has been shown to play a key role, but relatively little is understood about how inflammation changes over time among young individuals. Additionally, how psychosocial factors like stress may influence changes in inflammation earlier in the lifespan is not entirely clear. Thus, the current three-wave longitudinal study examined the developmental trajectory of CRP, a marker of systemic inflammation, over a 4-year period from mid-adolescence into young adulthood. Between- and within-person differences in stress in relation to changes in CRP were also examined. Method: A sample of 350 individuals was recruited during mid-adolescence and participated in 1 to 3 assessments, 2 years apart. At each assessment, participants provided dried blood spots for the assessment of CRP and reported on recent major life events, perceived stress, and daily interpersonal stress. Results: Multilevel modeling indicated that CRP increased with age, and within-person increases in perceived stress, but not life events or daily stress, were associated with higher CRP. Between- person differences in average levels of stress from mid-adolescence into young adulthood were not associated with changes in CRP. Conclusion: These findings suggest that the link between stress and systemic inflammation between mid-adolescence and young adulthood may be most affected by contemporaneous experiences of perceived stress. There was little evidence to suggest that CRP trajectories varied by between-person differences in overall average levels of perceived stress, life events, and daily stress.
C1 [Chiang, Jessica J.] Northwestern Univ, Inst Policy Res, Evanston, IL USA.
   [Park, Heejung] Bryn Mawr Coll, Dept Psychol, Bryn Mawr, PA 19010 USA.
   [Almeida, David M.] Penn State Univ, Dept Human Dev & Family Studies, University Pk, PA 16802 USA.
   [Bower, Julienne E.; Irwin, Michael R.; Fuligni, Andrew J.] Univ Calif Los Angeles, Dept Psychiat & Biobehav Sci, Cousins Ctr Psychoneuroimmunol, Los Angeles, CA 90024 USA.
   [Bower, Julienne E.; Irwin, Michael R.; Fuligni, Andrew J.] Univ Calif Los Angeles, Dept Psychol, Los Angeles, CA USA.
   [Cole, Steve W.] Univ Calif Los Angeles, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90024 USA.
   [Cole, Steve W.] Univ Calif Los Angeles, Cousins Ctr Psychoneuroimmunol, Los Angeles, CA USA.
   [McCreath, Heather; Seeman, Teresa E.] Univ Calif Los Angeles, Dept Med, Div Geriatr, Los Angeles, CA 90024 USA.
C3 Northwestern University; Bryn Mawr College; Pennsylvania Commonwealth
   System of Higher Education (PCSHE); Pennsylvania State University; Penn
   State Behrend; Pennsylvania State University - University Park;
   University of California System; University of California Los Angeles;
   University of California System; University of California Los Angeles;
   University of California System; University of California Los Angeles;
   University of California System; University of California Los Angeles;
   University of California System; University of California Los Angeles
RP Chiang, JJ (corresponding author), Northwestern Univ, Fdn Hlth Res Ctr, 1801 Maple Ave,Suite 2450, Evanston, IL 60201 USA.
EM jessica.chiang@northwestern.edu
RI Cole, Steve/KYO-7764-2024; Irwin, Michael/H-4870-2013
OI Park, Heejung/0000-0003-1574-4208; McCreath,
   Heather/0000-0003-0804-8722; Irwin, Michael/0000-0002-1502-8431
FU National Heart, Lung, and Blood Institute [F32-HL134276]; Eunice Kennedy
   Shriver National Institute of Child Health and Human Development
   [R01-HD062547, P2C-HD041022]; National Institute on Aging [P30-AG028748,
   P30-AG017265]; Eunice Kennedy Shriver National Institute of Child Health
   and Human Development [P2CHD041022] Funding Source: NIH RePORTER
FX Preparation of this article was supported by the National Heart, Lung,
   and Blood Institute (F32-HL134276 to Jessica J. Chiang). Collection of
   data was supported by funding from the Eunice Kennedy Shriver National
   Institute of Child Health and Human Development (R01-HD062547;
   P2C-HD041022), and the National Institute on Aging (P30-AG028748;
   P30-AG017265).
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NR 51
TC 22
Z9 29
U1 0
U2 27
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 0278-6133
EI 1930-7810
J9 HEALTH PSYCHOL
JI Health Psychol.
PD MAR
PY 2019
VL 38
IS 3
BP 259
EP 267
DI 10.1037/hea0000701
PG 9
WC Psychology, Clinical; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology
GA HL3IS
UT WOS:000458608100008
PM 30762405
OA Green Accepted, hybrid, Green Submitted
DA 2025-06-11
ER

PT J
AU Herhaus, B
   Petrowski, K
AF Herhaus, Benedict
   Petrowski, Katja
TI Cortisol Stress Reactivity to the Trier Social Stress Test in Obese
   Adults
SO OBESITY FACTS
LA English
DT Article
DE Obesity; Hypothalamic-pituitary-adrenocortical (HPA) axis; Cortisol;
   Trier Social Stress Test (TSST)
ID 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1; PITUITARY-ADRENAL AXIS;
   SALIVARY CORTISOL; ABDOMINAL OBESITY; PSYCHOLOGICAL STRESS; COGNITIVE
   APPRAISALS; PSYCHOSOCIAL STRESS; METABOLIC SYNDROME; COMFORT FOOD;
   RESPONSES
AB Objective: Approximately 600 million adults worldwide suffer from obesity. In addition to individual's eating behavior and lack of physical activity in the development of obesity and overweight, psychosocial stress as well as hormonal stress reactivity must also be considered as important contributing factors. In the current study we compared the cortisol stress response pathway in a psychosocial stress induction (Trier Social Stress Test; TSST) with obese individuals and normal-weight controls. Method: 32 obese individuals (17 females; mean age = 33.94 years, SD = 11.31 years) and 32 normal-weight controls (17 females; mean age = 29.09 years, SD = 10.46 years) underwent the TSST. The salivary cortisol responses and three appraisal questionnaires (Primary Appraisal Secondary Appraisal, Visual Analogue Scale, Trier Inventory for Chronic Stress) were measured. Results: After stress induction, there was a significant main group difference between the obese individuals and the normal-weight controls for cortisol, with lower baseline and post-stress cortisol levels in the obese individuals. Nevertheless, the obese individuals as well as the normal-weight controls showed no significant difference in the self-reported assessment of the stress condition but some significant differences in the cognitive appraisal of the TSST. Conclusion: In conclusion, the induction of psychosocial stress showed differences in the cortisol patterns between the obese individuals and the normal-weight controls. Furthermore, the present data suggest that obesity leads to lower cortisol activity, which may indicate alterations in the Hypothalamic-pituitary-adrencortical (HPA) axis. (C) 2018 The Author(s) Published by S. Karger GmbH, Freiburg
C1 [Herhaus, Benedict; Petrowski, Katja] Univ Med Mainz, Clin & Policlin Psychosomat Med & Psychotherapy, Med Psychol & Med Sociol, Duesbergweg 6, DE-55128 Mainz, Germany.
C3 Johannes Gutenberg University of Mainz
RP Herhaus, B (corresponding author), Univ Med Mainz, Clin & Policlin Psychosomat Med & Psychotherapy, Med Psychol & Med Sociol, Duesbergweg 6, DE-55128 Mainz, Germany.
EM bherhaus@uni-mainz.de
FU DFG [276734837]
FX This study was funded by the DFG project "Comparison of the chewing
   behavior of patients with obesity and healthy controls under resting and
   stress condition" (Project-number: 276734837).
CR Abraham SB, 2013, OBESITY, V21, pE105, DOI 10.1002/oby.20083
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   World Health Organization, OB OV 2016
NR 43
TC 28
Z9 29
U1 1
U2 12
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1662-4025
EI 1662-4033
J9 OBESITY FACTS
JI Obes. Facts
PY 2018
VL 11
IS 6
BP 491
EP 500
DI 10.1159/000493533
PG 10
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA HG2CJ
UT WOS:000454769700006
PM 30537716
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Kowal, C
   Peyre, H
   Amad, A
   Pelissolo, A
   Leboyer, M
   Schürhoff, F
   Pignon, B
AF Kowal, Celia
   Peyre, Hugo
   Amad, Ali
   Pelissolo, Antoine
   Leboyer, Marion
   Schurhoff, Franck
   Pignon, Baptiste
TI Psychotic, Mood, and Anxiety Disorders and Venous Thromboembolism: A
   Systematic Review and Meta-Analysis
SO PSYCHOSOMATIC MEDICINE
LA English
DT Review
DE venous thromboembolism disease; deep venous thrombosis; pulmonary
   embolism; psychotic disorders; bipolar disorders; depression
ID DEEP-VEIN THROMBOSIS; TOTAL JOINT ARTHROPLASTY; ANTIPSYCHOTIC-DRUGS;
   BIPOLAR DISORDER; RISK-FACTORS; PULMONARY-EMBOLISM; METABOLIC SYNDROME;
   SEDENTARY BEHAVIOR; PHYSICAL-ACTIVITY; ADVERSE EVENTS
AB Objective Several studies have shown that psychiatric disorders can be associated with venous thromboembolism (VTE) risk, that is, pulmonary embolism (PE) and/or deep vein thrombosis (DVT). In this study, we provide a systematic review and meta-analyses of the studies addressing this issue. Methods All studies addressing the risk of VTE phenomena (whole VTE, PE, DVT, fatal VTE) in individuals with psychotic, mood, and anxiety disorders published between 1998 and 2019 were reviewed and included in the meta-analyses. Main characteristics of the studies and data concerning VTE risk were extracted. The methodological qualities of the studies were also analyzed. A random-effects meta-analysis model was used. A meta-analysis was conducted separately for each disorder, as well as separately for unadjusted and adjusted studies. Meta-analyses were repeated considering only good-quality studies. Heterogeneity was assessed. Results Sixteen studies were reviewed and 15 included in the meta-analyses. Psychotic and bipolar disorders were significantly associated with VTE risk (VTE, DVT, PE, and fatal VTE for psychotic disorder: odds ratios [ORs] between 1.29 and 2.20; VTE, DVT, and PE for bipolar disorder: ORs between 1.22 and 2.14). Depression and anxiety disorders were associated with VTE risk only in adjusted analyses (DVT and PE for depression: ORs = 1.29; VTE and PE for anxiety disorders: ORs between 1.14 and 1.49). Conclusions The risk of VTE among individuals with psychiatric disorders may be explained by hypercoagulability and stasis, with both being related to, and independent of, treatment adverse effects. VTE risk should be taken into consideration in the treatment for people with psychiatric disorders.
C1 [Kowal, Celia] GH Henri Mondor, AP HP, Serv Pharm, Creteil, France.
   [Peyre, Hugo] Hop Univ Robert Debre, AP HP, Serv Pedopsychiat, Paris, France.
   [Pelissolo, Antoine; Leboyer, Marion; Schurhoff, Franck; Pignon, Baptiste] GH Henri Mondor, AP HP, DMU IMPACT, Serv Psychiat, Creteil, France.
   [Pelissolo, Antoine; Leboyer, Marion; Schurhoff, Franck; Pignon, Baptiste] INSERM, U955, Team 15, Creteil, France.
   [Pelissolo, Antoine; Leboyer, Marion; Schurhoff, Franck; Pignon, Baptiste] Fdn FondaMental, Creteil, France.
   [Pelissolo, Antoine; Leboyer, Marion; Schurhoff, Franck; Pignon, Baptiste] UPEC, Fac Med, Creteil, France.
   [Amad, Ali] Univ Lille, CNRS, UMR 9193, PsyCH SCALab, Lille, France.
   [Amad, Ali] CHU Lille, Pole Psychiat, Unite CURE, Lille, France.
   [Amad, Ali] Federat Reg Rech Sante Mentale F2RSM Hauts de Fra, Lille, France.
   [Amad, Ali] Coll London, Inst Psychiat Psychol & Neurosci, London, England.
C3 Universite Paris-Est-Creteil-Val-de-Marne (UPEC); Assistance Publique
   Hopitaux Paris (APHP); Hopital Universitaire Henri-Mondor - APHP;
   Assistance Publique Hopitaux Paris (APHP); Universite Paris Cite;
   Hopital Universitaire Robert-Debre - APHP; Universite
   Paris-Est-Creteil-Val-de-Marne (UPEC); Assistance Publique Hopitaux
   Paris (APHP); Hopital Universitaire Henri-Mondor - APHP; Institut
   National de la Sante et de la Recherche Medicale (Inserm); Universite
   Paris-Est-Creteil-Val-de-Marne (UPEC); Universite
   Paris-Est-Creteil-Val-de-Marne (UPEC); Centre National de la Recherche
   Scientifique (CNRS); CNRS - Institute for Humanities & Social Sciences
   (INSHS); Universite de Lille; Universite de Lille; CHU Lille; University
   of London; University College London
RP Pignon, B (corresponding author), CHU Creteil, Grp Hosp Henri Mondor, Hop Albert Chenevier, AP HP, 40 Rue Mesly, F-94000 Creteil, France.
EM celia.kowal@hotmail.fr; peyrehugo@yahoo.fr; ALI.AMAD@CHRU-LILLE.FR;
   antoine.pelissolo@aphp.fr; marion.leboyer@aphp.fr;
   franck.schurhoff@aphp.fr; baptistepignon@yahoo.fr
RI Leboyer, Marion/AAW-3648-2021
OI Amad, Ali/0000-0002-9029-2910
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NR 77
TC 36
Z9 38
U1 0
U2 7
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0033-3174
EI 1534-7796
J9 PSYCHOSOM MED
JI Psychosom. Med.
PD NOV-DEC
PY 2020
VL 82
IS 9
BP 838
EP 849
DI 10.1097/PSY.0000000000000863
PG 12
WC Psychiatry; Psychology; Psychology, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry; Psychology
GA PB0RT
UT WOS:000596036200005
PM 32947580
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Poojari, PG
   Khan, S
   Shenoy, S
   Shetty, S
   Pai, KSV
   Acharya, LD
   Bose, S
   Thunga, G
AF Poojari, Pooja Gopal
   Khan, Sohil
   Shenoy, Sonia
   Shetty, Sahana
   Pai, Keshava
   Acharya, Leelavathi D. D.
   Bose, Swarnali
   Thunga, Girish
TI Perspectives of patients and healthcare professionals on metabolic
   monitoring of adult prescribed second-generation antipsychotics for
   severe mental illness: A meta-synthesis
SO PLOS ONE
LA English
DT Article
ID PHYSICAL HEALTH; EXPERIENCES; PEOPLE; VIEWS; SERVICES; CLIENTS
AB ObjectivesWe conducted a meta-synthesis of qualitative studies to synthesize the views of psychiatric patients on second-generation antipsychotics (SGAs) and the healthcare providers about the metabolic monitoring of adult-prescribed SGAs. MethodsA systematic search was conducted in four databases through SCOPUS, PubMed, EMBASE, and CINAHL to identify qualitative studies of patients' and healthcare professionals' perspectives on the metabolic monitoring of SGAs. Initially, titles and abstracts were screened to exclude articles that were not relevant followed by full-text reading. Study quality was assessed by using Critical Appraisal Skills Program (CASP) criteria. Themes were synthesized and presented as per the Interpretive data synthesis process (Evans D, 2002). ResultsA total of 15 studies met the inclusion criteria and were analyzed in meta-synthesis. Four themes were identified: 1. Barriers to metabolic monitoring; 2. Patient related concerns to metabolic monitoring; 3. Support system by mental health services to promote metabolic monitoring; and 4. Integrating physical health with mental health services. From the participants' perspectives, barriers to metabolic monitoring were accessibility of services, lack of education and awareness, time/resource constraints, financial hardship, lack of interest on metabolic monitoring, patient capacity and motivation to maintain physical health and role confusion and impact on communication. Education and training on monitoring practices as well as integrated mental health services for metabolic monitoring to promote quality and safe use of SGAs are the most likely approaches to promote adherence to best practices and minimize treatment-related metabolic syndrome in this highly vulnerable cohort. ConclusionThis meta-synthesis highlights key barriers from the perspectives of patients and healthcare professionals regarding the metabolic monitoring of SGAs. These barriers and suggested remedial strategies are important to pilot in the clinical setting and to assess the impact of the implementation of such strategies as a component of pharmacovigilance to promote the quality use of SGAs as well as to prevent and/or manage SGAs-induced metabolic syndrome in severe and complex mental health disorders.
C1 [Poojari, Pooja Gopal; Acharya, Leelavathi D. D.; Thunga, Girish] Manipal Acad Higher Educ, Manipal Coll Pharmaceut Sci, Dept Pharm Practice, Manipal, Karnataka, India.
   [Khan, Sohil] Griffith Univ, Menzies Hlth Inst, Sch Pharm & Med Sci, Southport, Australia.
   [Shenoy, Sonia] Manipal Acad Higher Educ, Kasturba Med Coll, Dept Psychiat, Manipal, Karnataka, India.
   [Shetty, Sahana] Manipal Acad Higher Educ, Kasturba Med Coll, Dept Endocrinol, Manipal, Karnataka, India.
   [Pai, Keshava] Kasturba Med Coll & Hosp, Dept Psychiat, Mangalore, Karnataka, India.
   [Bose, Swarnali] Cent Inst Psychiat, Dept Clin Psychol, Ranchi, Jharkhand, India.
C3 Manipal Academy of Higher Education (MAHE); Griffith University;
   Griffith University - Gold Coast Campus; Menzies Health Institute
   Queensland; Manipal Academy of Higher Education (MAHE); Kasturba Medical
   College, Manipal; Manipal Academy of Higher Education (MAHE); Kasturba
   Medical College, Manipal; Manipal Academy of Higher Education (MAHE);
   Kasturba Medical College, Mangalore; Central Institute of Psychiatry
RP Thunga, G (corresponding author), Manipal Acad Higher Educ, Manipal Coll Pharmaceut Sci, Dept Pharm Practice, Manipal, Karnataka, India.
EM girish.thunga@manipal.edu
RI Shetty, Sahana/AAA-6271-2022; Shenoy, Sonia/AAU-6047-2020; Pai,
   Keshava/LTE-0063-2024
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NR 32
TC 4
Z9 4
U1 0
U2 0
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD APR 19
PY 2023
VL 18
IS 4
AR e0283317
DI 10.1371/journal.pone.0283317
PG 19
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA G7EP0
UT WOS:000990750000021
PM 37075039
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Morgan, VA
   Waterreus, A
   Ambrosi, T
   Badcock, JC
   Cox, K
   Watts, GF
   Shymko, G
   Velayudhan, A
   Dragovic, M
   Jablensky, A
AF Morgan, Vera A.
   Waterreus, Anna
   Ambrosi, Taryn
   Badcock, Johanna C.
   Cox, Kay
   Watts, Gerald F.
   Shymko, Gordon
   Velayudhan, Ajay
   Dragovic, Milan
   Jablensky, Assen
TI Mental health recovery and physical health outcomes in psychotic
   illness: Longitudinal data from the Western Australian survey of high
   impact psychosis catchments
SO AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
LA English
DT Article
DE Psychotic disorders; recovery; physical health; service utilisation;
   functioning
ID NEW-ZEALAND COLLEGE; NATIONAL-SURVEY; RISK-FACTORS; PEOPLE; RELIABILITY;
   DISORDERS; INSTRUMENT; LITERACY; SCHIZOPHRENIA; METAANALYSIS
AB Objective: There is a dearth of longitudinal data on outcomes in prevalent cases of psychotic illness across a range of ages and levels of chronicity. Our aim was to describe changes over time in mental and physical health outcomes, as well as patterns of service utilisation that may have influenced outcomes, in a representative prevalence sample of 641 Western Australians with a psychotic illness who, at Wave 1, were part of the National Survey of High Impact Psychosis. Methods: In Wave 1 (2010, 2012), a two-phase design was employed to ensure representativeness: Phase 1 psychosis screening took place in public mental health and non-government organisation services, while, in Phase 2, a randomised sample was interviewed. In Wave 2, 380/641 (59%) of participants were re-interviewed, with interviews staggered between 2013 and 2016 (follow-up time: 2.3-5.6 years). Data collection covered mental and physical health, functioning, cognition, social circumstances and service utilisation. Mental health outcomes were categorised as symptomatic, functional and personal recovery. Physical health outcomes covered metabolic syndrome and its component criteria. Results: In mental health, there were encouraging improvements in symptom profiles, variable change in functional recovery and some positive findings for personal recovery, but not quality of life. Participants ranked physical health second among challenges. Metabolic syndrome had increased significantly. While treatment for underlying cardiovascular risk conditions had improved, rates of intervention were still very low. More people were accessing general practices and more frequently, but there were sharp and significant declines in access to community rehabilitation, psychosocial interventions and case management. Conclusion: Although we observed some positive outcomes over time, the sharp decline in access to evidence-based interventions such as community rehabilitation, psychosocial interventions and case management is of great concern and augurs poorly for recovery-oriented practice. Changes in service utilisation appear to have influenced the patterns found.
C1 [Morgan, Vera A.; Waterreus, Anna; Ambrosi, Taryn] Univ Western Australia, Sch Populat & Global Hlth, Neuropsychiat Epidemiol Res Unit, 35 Stirling Highway, Perth, WA 6009, Australia.
   [Morgan, Vera A.; Waterreus, Anna; Dragovic, Milan; Jablensky, Assen] Univ Western Australia, Sch Med, Div Psychiat, Ctr Clin Res Neuropsychiat, Perth, WA, Australia.
   [Morgan, Vera A.; Dragovic, Milan] North Metropolitan Hlth Serv Mental Hlth, Clin Res Ctr, Perth, WA, Australia.
   [Badcock, Johanna C.] Univ Western Australia, Sch Psychol Sci, Perth, WA, Australia.
   [Cox, Kay; Watts, Gerald F.] Univ Western Australia, Sch Med, Fac Hlth & Med Sci, Perth, WA, Australia.
   [Watts, Gerald F.] Royal Perth Hosp, Dept Cardiol, Lipid Disorders Clin, Perth, WA, Australia.
   [Shymko, Gordon] Peel & Rockingham Kwinana Mental Hlth Serv, South Metropolitan Hlth Serv, Rockingham, WA, Australia.
   [Velayudhan, Ajay] Fremantle Hosp, Fremantle Hosp Mental Hlth Serv, Fiona Stanley Fremantle Hosp Grp, South Metropolitan Hlth Serv, Fremantle, WA, Australia.
C3 University of Western Australia; University of Western Australia; North
   Metropolitan Health Service; University of Western Australia; University
   of Western Australia; East Metropolitan Health Service; Royal Perth
   Hospital; South Metropolitan Health Service; South Metropolitan Health
   Service; Fiona Stanley Fremantle Hospitals Group; Fremantle Hospital
RP Morgan, VA (corresponding author), Univ Western Australia, Sch Populat & Global Hlth, Neuropsychiat Epidemiol Res Unit, 35 Stirling Highway, Perth, WA 6009, Australia.
EM vera.morgan@uwa.edu.au
RI Watts, Gerald/HII-8530-2022; Morgan, Vera/U-4851-2019; Badcock,
   Johanna/C-3682-2013
OI Ambrosi, Taryn/0000-0001-7641-8639; Waterreus, Anna/0000-0002-1648-7701;
   Watts, Gerald/0000-0003-2276-1524
FU National Health and Medical Research Council [APP1046729]; Australian
   Government Department of Health and Ageing, North Metropolitan Health
   Services Mental Health (Western Australia); Western Australian Mental
   Health Commission
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: Wave 2 of
   this study was funded by the National Health and Medical Research
   Council (APP1046729). Wave 1 was funded by the Australian Government
   Department of Health and Ageing, North Metropolitan Health Services
   Mental Health (Western Australia) and the Western Australian Mental
   Health Commission.
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NR 47
TC 20
Z9 20
U1 1
U2 6
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0004-8674
EI 1440-1614
J9 AUST NZ J PSYCHIAT
JI Aust. N. Z. J. Psych.
PD JUL
PY 2021
VL 55
IS 7
BP 711
EP 728
AR 0004867420954268
DI 10.1177/0004867420954268
EA SEP 2020
PG 18
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA SU8HO
UT WOS:000570329900001
PM 32921130
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Qureshi, F
   Derks, IPM
   Jaddoe, VWV
   Williams, MA
   Koenen, KC
   Tiemeier, H
   Kubzansky, LD
AF Qureshi, Farah
   Derks, Ivonne P. M.
   Jaddoe, Vincent W. V.
   Williams, Michelle A.
   Koenen, Karestan C.
   Tiemeier, Henning
   Kubzansky, Laura D.
TI Mental Health in Early Childhood and Changes in Cardiometabolic
   Dysregulation by Preadolescence
SO PSYCHOSOMATIC MEDICINE
LA English
DT Article
DE child mental health; cardiometabolic risk; childhood origins of disease;
   BMI = body mass index; CBCL = Child Behavior Checklist; CI = confidence
   interval; CRP = C-reactive protein; DBP = diastolic blood pressure; HDL
   = high-density lipoprotein cholesterol; nHDL = non-HDL cholesterol; SBP
   = systolic blood pressure
AB Objective
   Poor mental health in childhood is associated with a greater risk of cardiometabolic disease in adulthood, but less is known about when these associations begin to emerge. This study tests whether poor mental health (indexed by emotional and behavioral problems) in early childhood predicts increases in cardiometabolic dysregulation over 4 years of follow-up. Methods
   Data are from 4327 participants in the Generation R Study. Problem behaviors were reported by mothers using the Child Behavior Checklist at age 6 years. Repeated measurements of six cardiometabolic parameters were collected at ages 6 and 10 years: high-density lipoprotein cholesterol, non-high-density lipoprotein cholesterol, systolic and diastolic blood pressures, C-reactive protein, and body mass index. Standardized measures were used to create continuous cardiometabolic dysregulation scores at ages 6 and 10 years. Change in dysregulation was defined as the difference in dysregulation scores over time. Cross-sectional and prospective associations were tested using linear regression, sequentially adjusting for relevant confounders. Additional analyses examined whether prospective relationships were robust to adjustment for baseline levels of dysregulation. Results
   There was no association between child problem behaviors and cardiometabolic dysregulation at age 6 years. However, higher levels of problem behaviors predicted increases in cardiometabolic dysregulation (beta = 0.12, 95% confidence interval = 0.00-0.23) from ages 6 to 10 years. Conclusions
   Worse child mental health may be associated with increases in cardiometabolic dysregulation by preadolescence. To our knowledge, this is the first study to demonstrate that adverse physiologic effects of psychological distress identified in adult populations may be observed as early as childhood.
C1 [Qureshi, Farah; Tiemeier, Henning; Kubzansky, Laura D.] Harvard TH Chan Sch Publ Hlth, Dept Social & Behav Sci, 401 Pk Dr,Off 428-F, Boston, MA 02215 USA.
   [Derks, Ivonne P. M.] Erasmus Univ, Dept Psychol Educ & Child Studies, Rotterdam, Netherlands.
   [Derks, Ivonne P. M.] Erasmus MC, Dept Child & Adolescent Psychiat Psychol, Rotterdam, Netherlands.
   [Jaddoe, Vincent W. V.] Erasmus MC, Generat R Study Grp, Dept Pediat, Rotterdam, Netherlands.
   [Williams, Michelle A.; Koenen, Karestan C.] Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA 02215 USA.
C3 Harvard University; Harvard T.H. Chan School of Public Health; Erasmus
   University Rotterdam - Excl Erasmus MC; Erasmus University Rotterdam;
   Erasmus University Rotterdam; Erasmus MC; Erasmus University Rotterdam;
   Erasmus MC; Harvard University; Harvard T.H. Chan School of Public
   Health
RP Qureshi, F (corresponding author), Harvard TH Chan Sch Publ Hlth, Dept Social & Behav Sci, 401 Pk Dr,Off 428-F, Boston, MA 02215 USA.
EM fqureshi@mail.harvard.edu
RI Koenen, Karestan/K-5402-2014; Tiemeier, Henning/H-6534-2019
OI Qureshi, Farah/0000-0002-9092-8085; Koenen,
   Karestan/0000-0003-2978-7655; Derks, Ivonne/0009-0009-0137-3697
FU Erasmus Medical Center Rotterdam; Erasmus University Rotterdam;
   Netherlands Organization for Health Research and Development (ZonMw);
   National Institutes of Health at the Harvard T.H. Chan School of Public
   Health [T32 098048, T32 CA 009001]; European Research Council
   [ERC-2014-CoG-648916]
FX Financial support for the Generation R Study comes from the Erasmus
   Medical Center Rotterdam, Erasmus University Rotterdam, and the
   Netherlands Organization for Health Research and Development (ZonMw).
   This publication is the work of the authors. F.Q. was funded by National
   Institutes of Health training grants T32 098048 and T32 CA 009001 at the
   Harvard T.H. Chan School of Public Health. V.W.V.J. received grants from
   the European Research Council (Consolidator Grant, ERC-2014-CoG-648916).
   The authors have no conflicts of interest to disclose.
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NR 49
TC 3
Z9 3
U1 1
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0033-3174
EI 1534-7796
J9 PSYCHOSOM MED
JI Psychosom. Med.
PD APR
PY 2021
VL 83
IS 3
BP 256
EP 264
DI 10.1097/PSY.0000000000000927
PG 9
WC Psychiatry; Psychology; Psychology, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry; Psychology
GA RM1CN
UT WOS:000639398400007
PM 33657082
OA Green Published, Green Accepted
DA 2025-06-11
ER

PT J
AU Ferder, L
   Inserra, F
   Martínez-Maldonado, M
AF Ferder, Leon
   Inserra, Felipe
   Martinez-Maldonado, Manuel
TI Inflammation and the metabolic syndrome:: Role of angiotensin II and
   oxidative stress
SO CURRENT HYPERTENSION REPORTS
LA English
DT Article
ID KAPPA-B ACTIVATION; C-REACTIVE PROTEIN; ADHESION MOLECULE-1 EXPRESSION;
   CONVERTING ENZYME-INHIBITION; CORONARY-ARTERY-DISEASE;
   NECROSIS-FACTOR-ALPHA; NITRIC-OXIDE; ANTIOXIDANT DEFENSES; RECEPTOR
   ANTAGONISM; INSULIN-RESISTANCE
AB Excess body weight, high blood pressure, and insulin resistance together have been denominated the metabolic syndrome. In, this, review, we analyze the potential role of angiotensin II (Ang II) and reactive oxygen species in Mediating inflammation in the metabolic syndrome. Ang II induces pro-inflammatory genes and other pro-inflamatory substances and increases oxidative stress that could damage, endothelium, myocardium, and renal tissue. Activation of nuclear, factor-kappa B and NAD(P)H oxidase are fundamental steps in these pro-inflammatory mechanisms in which intramitochondrial oxidative stress could play a critical role. This sequence of events might explain why reduction in Ang II synthesis by angiotensin converting enzyme inhibitors (ACEIs) and Ang II type I (ATI) receptor blockers (ARBs) have a protective effect against cardiovascular disease.
C1 Ponce Sch Med, Dept Physiol, Ponce, PR 00732 USA.
   Ponce Sch Med, Dept Pharmacol, Ponce, PR 00732 USA.
RP Ferder, L (corresponding author), Ponce Sch Med, Dept Physiol, Dr Ana Perez Marchand St,POB 7004, Ponce, PR 00732 USA.
EM leferder@psm.edu
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NR 66
TC 86
Z9 95
U1 0
U2 9
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1522-6417
EI 1534-3111
J9 CURR HYPERTENS REP
JI Curr. Hypertens. Rep.
PD JUN
PY 2006
VL 8
IS 3
BP 191
EP 198
DI 10.1007/s11906-006-0050-7
PG 8
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 105BE
UT WOS:000242003500003
PM 17147916
DA 2025-06-11
ER

PT J
AU Jiménez-Fernández, S
   Gurpegui, M
   Garrote-Rojas, D
   Gutiérrez-Rojas, L
   Carretero, MD
   Correll, CU
AF Jimenez-Fernandez, Sara
   Gurpegui, Manuel
   Garrote-Rojas, Daniel
   Gutierrez-Rojas, Luis
   Carretero, Maria D.
   Correll, Christoph U.
TI Oxidative stress parameters and antioxidants in adults with unipolar or
   bipolar depression versus healthy controls: Systematic review and
   meta-analysis
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Review
DE Antioxidants; Bipolar depression; Oxidative stress markers; Unipolar
   depression; Uric acid
ID URIC-ACID LEVELS; TERM ANTIDEPRESSANT TREATMENT; PITUITARY-ADRENAL AXIS;
   SEVERE MENTAL-ILLNESS; METABOLIC SYNDROME; MAJOR DEPRESSION;
   SUPEROXIDE-DISMUTASE; CARDIOVASCULAR-DISEASE; DIFFERENT PHASES; MOOD
   DISORDERS
AB Background: To study differences in oxidative stress markers and antioxidants among patients with bipolar depression (BPD) and unipolar depression (UPD).
   Methods: Data sources. Electronic MEDLINE/PubMed/Cochrane Library/Scopus/TripDatabase database search until 30/06/2021.
   Study selection. Included were articles comparing antioxidant or oxidative stress markers between adults with BPD or UPD and healthy controls (HCs).
   Data extraction. Two authors extracted data independently. Random effects meta-analysis, calculating standardized mean differences for results from >= 3 studies.
   Results: Oxidative stress markers reported in 40 studies 1 published repeatedly- (UPD, studies = 30 n = 3072; their HCs, n = 2856; BPD, studies = 11 n = 393; their HCs, n = 540; with 1 study reporting on both UPD and BPD) included thiobarbituric acid reactive substances (TBARS), antioxidant uric acid and antioxidant-enhancing enzymes superoxide dismutase (SOD), catalase (CAT) and glutathione-peroxidase (GPX).
   Compared with HCs, UPD and BPD were associated with significantly higher levels of TBARS, without differences between UPD and BPD (P = 0.11). Compared with HCs, UPD and BPD did not differ regarding the activity of the CAT (P = 0.28), SOD (P = 0.87) and GPX (P = 0.25) enzymes. However, uric acid levels were significantly higher vs HCs in BPD than in UPD among adult patients (P = 0.004). Results were heterogenous, which, for some parameters, decreased after stratification by the blood source (serum, plasma red blood cells, whole blood).
   Limitations: The main limitations are the small number of studies/participants in the BPD subgroup, and heterogeneity of the results.
   Summations: Both BPD and UPD may be associated with an impaired oxidative stress balance, with significantly higher uric acid levels vs. HCs in UPD than in BPD.
C1 [Jimenez-Fernandez, Sara; Gurpegui, Manuel; Gutierrez-Rojas, Luis; Carretero, Maria D.] Univ Granada, Inst Neurosci, Dept Psychiat & Res Grp, Granada, Spain.
   [Jimenez-Fernandez, Sara] Jaen Univ Hosp, Child & Adolescent Mental Hlth Unit, Jaen, Spain.
   [Garrote-Rojas, Daniel] Univ Granada, Dept Pedag, Granada, Spain.
   [Gutierrez-Rojas, Luis] San Cecilio Univ Hosp, Psychiat Serv, Granada, Spain.
   [Correll, Christoph U.] Zucker Hillside Hosp, Dept Psychiat Res, Northwell Hlth, Glen Oaks, NY USA.
   [Correll, Christoph U.] Zucker Sch Med Hofstra Northwell, Dept Psychiat & Mol Med, Hempstead, NY USA.
   [Correll, Christoph U.] Feinstein Inst Med Res, Ctr Psychiat Neurosci, Manhasset, NY USA.
   [Correll, Christoph U.] Charite Med Univ Berlin, Dept Child & Adolescent Psychiat, Berlin, Germany.
C3 University of Granada; University of Granada; Hospital Universitario San
   Cecilio; Northwell Health; Northwell Health; Northwell Health; Berlin
   Institute of Health; Free University of Berlin; Humboldt University of
   Berlin; Charite Universitatsmedizin Berlin
RP Jiménez-Fernández, S (corresponding author), Univ Granada, Dept Psychiat, Av Invest 11, Granada 18016, Spain.; Jiménez-Fernández, S (corresponding author), Univ Granada, Inst Neurosci, CTS 549 Res Grp, Av Invest 11, Granada 18016, Spain.
EM sarajimenezfer@hotmail.es
RI Rojas, Luis/AAI-1110-2021; Correll, Christoph/D-3530-2011;
   Jiménez-Fernández, Sara/MBV-1302-2025; Garrote Rojas,
   Daniel/AAB-5527-2022; Gurpegui, Manuel/JDD-0226-2023
OI Gutierrez-Rojas, Luis/0000-0003-0082-2189; Gurpegui,
   Manuel/0000-0002-1262-1627; Jimenez Fernandez, Sara/0000-0003-1515-2413
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NR 145
TC 35
Z9 36
U1 3
U2 11
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD OCT 1
PY 2022
VL 314
BP 211
EP 221
DI 10.1016/j.jad.2022.07.015
PG 11
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA 7S6LC
UT WOS:000910864800026
PM 35868596
DA 2025-06-11
ER

PT J
AU Carillon, J
   Lacan, D
   Rouanet, JM
AF Carillon, Julie
   Lacan, Dominique
   Rouanet, Jean-Max
TI SODB reduced obesity markers in hamsters Beneficial effects in hepatic
   and adipose tissue by modulating oxidative status
SO AGRO FOOD INDUSTRY HI-TECH
LA English
DT Article
DE adipose tissue; antioxidant defences; insulin sensitivity; liver; melon
   superoxide dismutase; metabolic syndrome
ID MELON SUPEROXIDE-DISMUTASE; HIGH-FAT DIET; INSULIN-RESISTANCE; METABOLIC
   SYNDROME; LIPID-PEROXIDATION; CAFETERIA DIET; RISK FACTOR; STRESS;
   SUPPLEMENTATION; INFLAMMATION
AB Obesity-related metabolic syndrome is often associated with an increased oxidative stress and a decrease of insulin sensitivity, inducing several modifications, particularly in adipose tissue. However, dietary antioxidants could prevent oxidative stress and insulin-induced damage. In this context, we evaluated the effects of a 1-month curative supplementation with SODB, a melon SOD, on the liver and adipose tissue of obese hamsters. SODB reduced body weight and obesity markers. These beneficial effects could be due to the increased expression of tissular antioxidant defense proteins. These findings suggest that SODB could exert its antioxidant properties by inducing the endogenous antioxidant defense. The mechanisms underlying this induction need to be further investigated.
C1 [Carillon, Julie; Lacan, Dominique] Bionov, F-34090 Montpellier, France.
   [Rouanet, Jean-Max] Univ Montpellier Sud France, UMR NUTRIPASS 204, F-34090 Montpellier, France.
C3 Institut de Recherche pour le Developpement (IRD); Universite de
   Montpellier
RP Rouanet, JM (corresponding author), Univ Montpellier Sud France, UMR NUTRIPASS 204, Pl Eugene Bataillon, F-34090 Montpellier, France.
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NR 30
TC 0
Z9 0
U1 0
U2 1
PU TEKNOSCIENZE PUBL
PI MILANO
PA VIALE BRIANZA 22, 20127 MILANO, ITALY
SN 1722-6996
EI 2035-4606
J9 AGRO FOOD IND HI TEC
JI Agro Food Ind. Hi-Tech
PD JUL-AUG
PY 2014
VL 25
IS 4
BP 14
EP 17
PG 4
WC Biotechnology & Applied Microbiology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Food Science & Technology
GA AW2TI
UT WOS:000346141500004
DA 2025-06-11
ER

PT J
AU Miricescu, D
   Greabu, M
   Totan, A
   Mohora, M
   Didilescu, A
   Mitrea, N
   Arsene, AL
   Spinu, T
   Totan, C
   Radulescu, R
AF Miricescu, Daniela
   Greabu, Maria
   Totan, Alexandra
   Mohora, Maria
   Didilescu, Andreea
   Mitrea, Niculina
   Arsene, Andreea L.
   Spinu, Tudor
   Totan, Cosmin
   Radulescu, Radu
TI OXIDATIVE STRESS - A POSSIBLE LINK BETWEEN SYSTEMIC AND ORAL DISEASES
SO FARMACIA
LA English
DT Article
DE oxidative stress; periodontitis; metabolic syndrome; oral cancer
ID GINGIVAL CREVICULAR FLUID; LIPID-PEROXIDATION; INSULIN-RESISTANCE;
   METABOLIC SYNDROME; CIGARETTE-SMOKE; ANTIOXIDANTS; PERIODONTITIS;
   ADIPONECTIN; PROTEIN; HEALTH
AB Oxidative stress (OS) plays a major role in the pathogenesis of a wide range of systemic and oral diseases. The aim of this review is to provide an overview of the ways in which OS may be considered a possible link between systemic and oral diseases. There is increasing evidence linking some oral diseases, e.g. periodontal disease to systemic diseases, such as cardiovascular diseases, metabolic syndrome, and diabetes. Tooth loss has been associated with a higher risk to develop several types of cancer. Malign progression of tumors has been correlated with the development of OS. This article summarizes the roles of OS emphasized in relevant studies, including our department experience, focused on the relationship between systemic and oral diseases.
C1 [Miricescu, Daniela; Greabu, Maria; Totan, Alexandra; Mohora, Maria; Didilescu, Andreea; Mitrea, Niculina; Arsene, Andreea L.; Spinu, Tudor; Totan, Cosmin; Radulescu, Radu] Carol Davila Univ Med & Pharm, Bucharest, Romania.
C3 Carol Davila University of Medicine & Pharmacy
RP Arsene, AL (corresponding author), Carol Davila Univ Med & Pharm, Bucharest, Romania.
EM andreeanitulescu@hotmail.com
RI Spinu, Tudor Claudiu/GON-8485-2022; Didilescu, Andreea/K-1135-2019;
   Daniela, Miricescu/G-8788-2016; Arsene, Andreea/AAD-4246-2020;
   radulescu, radu/HHC-0920-2022; Ripszky-Totan, Alexandra/JTT-4320-2023;
   Greabu, Maria/Q-9336-2019
OI Ripszky, Alexandra/0000-0002-4345-282X; Didilescu,
   Andreea/0000-0002-2915-5124; radulescu, radu/0000-0002-7469-0839
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NR 26
TC 17
Z9 17
U1 1
U2 17
PU SOC STIINTE FARMACEUTICE ROMANIA
PI BUCURESTI
PA BUCURESTI, STR TRAIAN VUIA 6, SECT 1, BUCURESTI, 020956, ROMANIA
SN 0014-8237
EI 2065-0019
J9 FARMACIA
JI Farmacia
PD MAY-JUN
PY 2011
VL 59
IS 3
BP 329
EP 337
PG 9
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 782OO
UT WOS:000292019200004
DA 2025-06-11
ER

PT J
AU Tran, V
   De Silva, TM
   Sobey, CG
   Lim, K
   Drummond, GR
   Vinh, A
   Jelinic, M
AF Tran, Vivian
   De Silva, T. Michael
   Sobey, Christopher G.
   Lim, Kyungjoon
   Drummond, Grant R.
   Vinh, Antony
   Jelinic, Maria
TI The Vascular Consequences of Metabolic Syndrome: Rodent Models,
   Endothelial Dysfunction, and Current Therapies
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Review
DE endothelial dysfunction; vascular disease; cardiometabolic
   abnormalities; nitric oxide; reactive oxygen species
ID HIGH-FAT-DIET; ACTIVATED PROTEIN-KINASE; NITRIC-OXIDE SYNTHESIS;
   DEPENDENT CONTRACTIONS; OXIDATIVE STRESS; VITAMIN-D; RESISTANCE
   ARTERIES; NAD(P)H OXIDASE; INDUCED OBESITY; NADPH OXIDASE
AB Metabolic syndrome is characterized by visceral obesity, dyslipidemia, hyperglycemia and hypertension, and affects over one billion people. Independently, the components of metabolic syndrome each have the potential to affect the endothelium to cause vascular dysfunction and disrupt vascular homeostasis. Rodent models of metabolic syndrome have significantly advanced our understanding of this multifactorial condition. In this mini-review we compare the currently available rodent models of metabolic syndrome and consider their limitations. We also discuss the numerous mechanisms by which metabolic abnormalities cause endothelial dysfunction and highlight some common pathophysiologies including reduced nitric oxide production, increased reactive oxygen species and increased production of vasoconstrictors. Additionally, we explore some of the current therapeutics for the comorbidities of metabolic syndrome and consider how these benefit the vasculature.
C1 [Tran, Vivian; De Silva, T. Michael; Sobey, Christopher G.; Lim, Kyungjoon; Drummond, Grant R.; Vinh, Antony; Jelinic, Maria] La Trobe Univ, Dept Physiol Anat & Microbiol, Bundoora, Vic, Australia.
C3 La Trobe University
RP Vinh, A (corresponding author), La Trobe Univ, Dept Physiol Anat & Microbiol, Bundoora, Vic, Australia.
EM a.vinh@latrobe.edu.au
RI Drummond, Grant/A-7427-2008; Vinh, Antony/JXO-0783-2024; Lim,
   Joon/AAX-7788-2020; Vinh, Antony/I-1563-2014; Sobey,
   Christopher/A-2786-2008
OI Vinh, Antony/0000-0001-8367-6134; Drummond, Grant/0000-0001-8556-9738;
   Tran, Vivian/0000-0001-5390-1919; Jelinic, Maria/0000-0001-9773-4972;
   Sobey, Christopher/0000-0001-6525-9097
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NR 114
TC 52
Z9 56
U1 0
U2 6
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD MAR 4
PY 2020
VL 11
AR 148
DI 10.3389/fphar.2020.00148
PG 10
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA LC7OM
UT WOS:000525522100001
PM 32194403
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Charlton, M
AF Charlton, Michael
TI Evolving aspects of liver transplantation for nonalcoholic
   steatohepatitis
SO CURRENT OPINION IN ORGAN TRANSPLANTATION
LA English
DT Review
DE liver transplantation; metabolic syndrome; NASH; obesity
ID FATTY LIVER; INSULIN-RESISTANCE; RISK-FACTORS; HEPATITIS-C; DISEASE;
   OBESITY; TRIAL; SUSCEPTIBILITY; PIOGLITAZONE; ANTIOXIDANTS
AB Purpose of review
   Nonalcoholic steatohepatitis (NASH), obesity, and the metabolic syndrome are highly prevalent. NASH, a rare indication for liver transplantation in the early 1990s, is now the third most common indication. This review considers key aspects of the liver transplantation for NASH.
   Recent findings
   NASH is one consequence of obesity, almost always occurring in the context of metabolic syndrome and oxidative stress. Recurrence of NASH can be severe. The components of metabolic syndrome are often exacerbated following liver transplantation by factors such as immunosuppression, and are important predictors of patient morbidity and mortality. Many aspects of the metabolic syndrome are modifiable. The roles bariatric surgery, nutritional and pharmacotherapy of NASH, and the impact of established and new immunosuppressive agents have recently evolved.
   Summary
   A nuanced approach is needed in management of obesity, metabolic syndrome, and immunosuppression in liver transplant recipients.
C1 [Charlton, Michael] Mayo Clin & Mayo Fdn, Dept Gastroenterol & Hepatol, Rochester, MN USA.
C3 Mayo Clinic
RP Charlton, M (corresponding author), Mayo Clin, Transplant Ctr, CH-10,200 1st St SW, Rochester, MN 55905 USA.
EM charlton.michael@mayo.edu
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NR 55
TC 46
Z9 46
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1087-2418
EI 1531-7013
J9 CURR OPIN ORGAN TRAN
JI Curr. Opin. Organ Transpl.
PD JUN
PY 2013
VL 18
IS 3
BP 251
EP 258
DI 10.1097/MOT.0b013e3283615d30
PG 8
WC Transplantation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Transplantation
GA 146UI
UT WOS:000319117600001
PM 23652610
DA 2025-06-11
ER

PT J
AU Woods, LCS
   Ahmadiyeh, N
   Baum, A
   Shimomura, K
   Li, Q
   Steiner, DF
   Turek, FW
   Takahashi, JS
   Churchill, GA
   Redei, EE
AF Woods, Leah C. Solberg
   Ahmadiyeh, Nasim
   Baum, Amber
   Shimomura, Kazuhiro
   Li, Qian
   Steiner, Donald F.
   Turek, Fred W.
   Takahashi, Joseph S.
   Churchill, Gary A.
   Redei, Eva E.
TI Identification of genetic loci involved in diabetes using a rat model of
   depression
SO MAMMALIAN GENOME
LA English
DT Article
ID QUANTITATIVE TRAIT LOCI; RESPONSIVE ADRENOCORTICAL AXIS; TOKUSHIMA FATTY
   RAT; SUSCEPTIBILITY LOCI; GK RATS; METABOLIC SYNDROME; HYPERTENSIVE-RAT;
   STRESS; INSULIN; MELLITUS
AB While diabetic patients often present with comorbid depression, the underlying mechanisms linking diabetes and depression are unknown. The Wistar Kyoto (WKY) rat is a well-known animal model of depression and stress hyperreactivity. In addition, the WKY rat is glucose intolerant and likely harbors diabetes susceptibility alleles. We conducted a quantitative trait loci (QTL) analysis in the segregating F-2 population of a WKY x Fischer 344 (F344) intercross. We previously published QTL analyses for depressive behavior and hypothalamic-pituitary-adrenal (HPA) activity in this cross. In this study we report results from the QTL analysis for multiple metabolic phenotypes, including fasting glucose, post-restraint stress glucose, postprandial glucose and insulin, and body weight. We identified multiple QTLs for each trait and many of the QTLs overlap with those previously identified using inbred models of type 2 diabetes (T2D). Significant correlations were found between metabolic traits and HPA axis measures, as well as forced swim test behavior. Several metabolic loci overlap with loci previously identified for HPA activity and forced swim behavior in this F-2 intercross, suggesting that the genetic mechanisms underlying these traits may be similar. These results indicate that WKY rats harbor diabetes susceptibility alleles and suggest that this strain may be useful for dissecting the underlying genetic mechanisms linking diabetes, HPA activity, and depression.
C1 [Woods, Leah C. Solberg] Med Coll Wisconsin, CRI TRBC 2415, Milwaukee, WI 53226 USA.
   [Woods, Leah C. Solberg; Ahmadiyeh, Nasim; Baum, Amber; Redei, Eva E.] Northwestern Univ, Feinberg Sch Med, Dept Psychiat & Behav Sci, Chicago, IL 60611 USA.
   [Woods, Leah C. Solberg; Ahmadiyeh, Nasim; Shimomura, Kazuhiro; Turek, Fred W.; Takahashi, Joseph S.] Northwestern Univ, Dept Neurobiol & Physiol, Evanston, IL 60208 USA.
   [Ahmadiyeh, Nasim] Brigham & Womens Hosp, Dept Surg, Boston, MA 02215 USA.
   [Baum, Amber] Natl Sci Fdn, Arlington, VA 22230 USA.
   [Li, Qian; Churchill, Gary A.] Jackson Lab, Bar Harbor, ME 04609 USA.
   [Steiner, Donald F.] Univ Chicago, Dept Med, Chicago, IL 60637 USA.
   [Takahashi, Joseph S.] Northwestern Univ, Howard Hughes Med Inst, Evanston, IL 60208 USA.
C3 Medical College of Wisconsin; Northwestern University; Feinberg School
   of Medicine; Northwestern University; Harvard University; Harvard
   University Medical Affiliates; Brigham & Women's Hospital; National
   Science Foundation (NSF); Jackson Laboratory; University of Chicago;
   Howard Hughes Medical Institute; Northwestern University
RP Woods, LCS (corresponding author), Med Coll Wisconsin, CRI TRBC 2415, 8701 Watertown Plank Rd, Milwaukee, WI 53226 USA.
EM lsolberg@mcw.edu
RI Takahashi, Joseph/Y-2781-2019; Churchill, Gary/AAY-7496-2020; Takahashi,
   Joseph/E-8482-2012
OI Ahmadiyeh, Nasim/0000-0002-4028-6539; Takahashi,
   Joseph/0000-0003-0384-8878
FU  [MH060789];  [NIH-R01GM076468]
FX This work was supported by grants MH060789 to ER and NIH-R01GM076468 to
   GAC. JST is an investigator in the Howard Hughes Medical Institute.
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NR 54
TC 10
Z9 15
U1 0
U2 8
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0938-8990
EI 1432-1777
J9 MAMM GENOME
JI Mamm. Genome
PD AUG
PY 2009
VL 20
IS 8
BP 486
EP 497
DI 10.1007/s00335-009-9211-8
PG 12
WC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
   Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
   Genetics & Heredity
GA 504ZY
UT WOS:000270658400004
PM 19697080
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Allen, JO
   Mezuk, B
   Byrd, DR
   Abelson, JL
   Rafferty, J
   Abelson, J
   White, C
   Jackson, JS
AF Allen, Julie Ober
   Mezuk, Briana
   Byrd, DeAnnah R.
   Abelson, James L.
   Rafferty, Jane
   Abelson, Jamie
   White, Christopher
   Jackson, James S.
TI Mechanisms of Cardiometabolic Health Outcomes and Disparities: What
   Characteristics of Chronic Stressors are Linked to HPA-Axis
   Dysregulation?
SO JOURNAL OF AGING AND HEALTH
LA English
DT Article
DE stress; cortisol; hypothalamic-pituitary-adrenal axis; cardiometabolic
   health; racial health disparities
ID RACIAL-DISCRIMINATION; PSYCHOLOGICAL STRESS; SOCIOECONOMIC-STATUS;
   SOCIAL DETERMINANTS; METABOLIC SYNDROME; CORTISOL PROFILES; LIFE; RISK;
   RACE; EPIDEMIOLOGY
AB Objectives: Chronic stressors are associated with cardiometabolic health conditions and disparities. Mechanisms linking stressors and health remain poorly understood. Methods: Two cohort studies (Cardiac Rehabilitation And The Experience [CREATE] and Tracking Risk Identification for Adult Diabetes [TRIAD]) with harmonized variables were used to examine relationships between six types of chronic stressors in adulthood and Hypothalamic-Pituitary-Adrenal (HPA) axis dysregulation, as indicated by blunted diurnal cortisol slopes, which are stress-sensitive biomarkers implicated in cardiometabolic health (merged N = 213, mean age 61, 18% Black). A secondary aim was to explore whether these chronic stressors accounted for Black-White disparities in HPA axis regulation. Results: Some chronic stressors were linked to HPA axis dysregulation, with recent stressors most salient (b = 0.00353, SE = 0.00133, p = .008). Black-White disparities in HPA axis regulation persisted after controlling for racial differences in chronic stressors, which reduced the disparity 11.46%. Discussion: Chronic stressors in adulthood may increase risk for HPA axis dysregulation and associated cardiometabolic health outcomes but may not be a key factor in racial disparities.
C1 [Allen, Julie Ober; White, Christopher] Univ Oklahoma, Dept Hlth & Exercise Sci, 1401 Asp Ave, Norman, OK 73019 USA.
   [Allen, Julie Ober; Mezuk, Briana] Univ Michigan, Res Ctr Grp Dynam, Ann Arbor, MI 48109 USA.
   [Mezuk, Briana] Univ Michigan, Dept Epidemiol, Ctr Social Epidemiol & Populat Hlth, Ann Arbor, MI 48109 USA.
   [Byrd, DeAnnah R.] Arizona State Univ, Edson Coll Nursing & Hlth Innovat, Phoenix, AZ USA.
   [Abelson, James L.] Univ Michigan, Dept Psychiat, Ann Arbor, MI 48109 USA.
   [Rafferty, Jane; Abelson, Jamie; Jackson, James S.] Univ Michigan, Inst Social Res, Ann Arbor, MI USA.
C3 University of Oklahoma System; University of Oklahoma - Norman;
   University of Michigan System; University of Michigan; University of
   Michigan System; University of Michigan; Arizona State University;
   Arizona State University-Downtown Phoenix; University of Michigan
   System; University of Michigan; University of Michigan System;
   University of Michigan
RP Allen, JO (corresponding author), Univ Oklahoma, Dept Hlth & Exercise Sci, 1401 Asp Ave, Norman, OK 73019 USA.
EM joallen@ou.edu
RI Mezuk, Briana/AAY-5321-2020; Allen, PhD, MPH, Julie Ober/Q-2895-2018
OI Mezuk, Briana/0000-0003-1798-2285; Byrd, DeAnnah/0000-0003-4384-6842;
   Allen, PhD, MPH, Julie Ober/0000-0002-3969-8130
FU National Institutes of Health; National Institute on Aging [T32
   AG000221]; National Institute on Minority Health and Health Disparities
   [P60 MD002249]; National Institute of Diabetes and Digestive and Kidney
   Diseases [P30 DK020572]; National Institute of Diabetes and Digestive
   and Kidney Diseases [P30DK020572] Funding Source: NIH RePORTER; National
   Institute on Aging [T32AG000221] Funding Source: NIH RePORTER
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: This work
   was supported by several grants from the National Institutes of Health
   including grants from the National Institute on Aging to the University
   of Michigan's Population Studies Center (T32 AG000221), the National
   Institute on Minority Health and Health Disparities to the Michigan
   Center for Integrative Approaches to Health Disparities (P60 MD002249),
   and the National Institute of Diabetes and Digestive and Kidney Diseases
   to the Michigan Diabetes Research Center Chem lab (P30 DK020572).
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NR 53
TC 5
Z9 6
U1 1
U2 6
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0898-2643
EI 1552-6887
J9 J AGING HEALTH
JI J. Aging Health
PD JUN
PY 2022
VL 34
IS 3
SI SI
BP 448
EP 459
AR 08982643221085903
DI 10.1177/08982643221085903
EA APR 2022
PG 12
WC Gerontology; Health Policy & Services
WE Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Health Care Sciences & Services
GA 1K3IL
UT WOS:000781648700001
PM 35411825
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Huang, SQ
   Chen, JW
   Zhang, H
   Wu, WJ
   Xue, S
   Zhu, ZH
   Ding, CH
AF Huang, Shiqian
   Chen, Jiawei
   Zhang, Hao
   Wu, Wenjing
   Xue, Song
   Zhu, Zhaohua
   Ding, Changhai
TI Inflammatory mechanisms underlying metabolic syndrome-associated and
   potential treatments
SO OSTEOARTHRITIS AND CARTILAGE OPEN
LA English
DT Article
DE Metabolic syndrome; Metabolic osteoarthritis; Obesity; Inflammatory
   mechanism
ID KNEE OSTEOARTHRITIS; HAND OSTEOARTHRITIS; KAPPA-B; EXTRACELLULAR-MATRIX;
   DIABETES-MELLITUS; SYNOVIAL-FLUID; ADIPOSE-TISSUE; RAT MODEL; LEPTIN;
   CARTILAGE
AB Objectives: Osteoarthritis (OA), a debilitating disease, has been recognized as a heterogenous disease, with metabolic syndrome-associated osteoarthritis (MetS-OA) emerging as a significant area of interest. Currently, the understanding of MOA remains limited, with a prevailing consensus attributing its etiology to the core components of metabolic syndrome: obesity, hyperglycemia, dyslipidemia, and hypertension. The aim of this review is to summarize the current understanding of the complex relationship between metabolic syndrome and OA from the perspectives of epidemiology and molecular biology, and to explore potential targeting strategies for metabolic syndrome in MetS-OA management. Methods: This narrative review evaluated literature (2010-2024) from PubMed, examining clinical and mechanistic evidence linking metabolic syndrome to OA, including therapeutic studies targeting MetS-OA. Results: Metabolic syndrome aggravate the cartilage injury in MetS-OA through metabolic biomarkers (adipokines, advanced glycation end-products and oxidized LDL), metabolic responses (oxidative stress, insulin resistance and ischemic hypoxic injuries), and abnormally activated cells (adipocytes and macrophages). It ultimately lead to the aggravation of synovitis in MetS-OA through inflammatory mediators. Conclusions: The exploration of the relationship between metabolic syndrome and OA could benefit the development of targeting strategies for MetS-OA, including currently FDA-approved drugs for the treatment of metabolic syndrome and potential drugs targeting metabolic factors, which might provide a novel avenue for the future management of MetS-OA.
C1 [Huang, Shiqian; Chen, Jiawei; Zhang, Hao; Zhu, Zhaohua; Ding, Changhai] Southern Med Univ, Zhujiang Hosp, Clin Res Ctr, Guangzhou 510280, Peoples R China.
   [Wu, Wenjing] Southern Med Univ, Zhujiang Hosp, Sch Clin Med 2, Guangzhou, Peoples R China.
   [Xue, Song] Hong Kong Univ Sci & Technol, Shenzhen Peking Univ, Peking Univ Shenzhen Hosp, Med Ctr,Dept Sports Med, Shenzhen, Peoples R China.
   [Zhu, Zhaohua] Univ Sydney, Royal North Shore Hosp & Sydney Musculoskeletal Hl, Kolling Inst, Dept Rheumatol, Sydney, Australia.
C3 Southern Medical University - China; Southern Medical University -
   China; Peking University; Hong Kong University of Science & Technology;
   University of Sydney; Kolling Institute of Medical Research
RP Zhu, ZH; Ding, CH (corresponding author), Southern Med Univ, Zhujiang Hosp, Clin Res Ctr, Guangzhou 510280, Peoples R China.
EM hsq847073754@163.com; cjw_smu@163.com; 1274821726@qq.com;
   2352675283@qq.com; freexuesong@163.com; changhai.ding@utas.edu.au;
   zhaohua.zhu@utas.edu.au
RI Zhu, Zhaohua/HSB-8018-2023; Shiqian, Huang/AFU-7362-2022
FU National Key Research & Develop-ment Program of China-Strategic Science
   and Technology Innovation Cooperation [2023YFE0209700]; National Natural
   Science Foundation of China [82373653]
FX The work was supported by the National Key Research & Develop-ment
   Program of China-Strategic Science and Technology Innovation Cooperation
   (2023YFE0209700) and the National Natural Science Foundation of China
   (82373653) .
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NR 94
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
EI 2665-9131
J9 OSTEOARTHR CARTIL OP
JI Osteoarthr. Cartil. Open
PD JUN
PY 2025
VL 7
IS 2
AR 100614
DI 10.1016/j.ocarto.2025.100614
PG 9
WC Orthopedics; Rheumatology
WE Emerging Sources Citation Index (ESCI)
SC Orthopedics; Rheumatology
GA 2LY2P
UT WOS:001485800100001
PM 40421161
DA 2025-06-11
ER

PT J
AU Iyer, D
   Mishra, N
   Agrawal, A
AF Iyer, Divyaanka
   Mishra, Navya
   Agrawal, Anurag
TI Mitochondrial Function in Allergic Disease
SO CURRENT ALLERGY AND ASTHMA REPORTS
LA English
DT Review
DE Asthma; Metabolic syndrome; Allergy; Mitochondrial dysfunction; Systemic
   inflammation; Air pollution; Mitochondrial transfer therapy
ID INDEPENDENT ATP RELEASE; OXIDATIVE STRESS; NLRP3 INFLAMMASOME;
   LIPID-PEROXIDATION; AIR-POLLUTION; RESPIRATORY-FUNCTION; METABOLIC
   SYNDROME; EPITHELIAL-CELLS; DNA-DAMAGE; ASTHMA
AB Purpose of the Review The connections between allergy, asthma and metabolic syndrome are becoming increasingly clear. Recent research suggests a unifying mitochondrial link between the diverse phenotypes of these interlinked morbidities. The scope of this review is to highlight cellular mechanisms, epidemiology and environmental allergens influencing mitochondrial function and its importance in allergy and asthma. We briefly also consider the potential of mitochondria-targeted therapies in prevention and cure.
   Recent Findings Recent research has shown allergy, asthma and metabolic syndrome to be linked to mitochondrial dysfunction. Environmental pollutants and allergens are observed to cause mitochondrial dysfunction, primarily by inducing oxidative stress and ROS production. Malfunctioning mitochondria change the bioenergetics of the cell and its metabolic profile to favour systemic inflammation, which drives all three types of morbidities.
   Summary Given the existing experimental evidence, approaches targeting mitochondria (e.g. antioxidant therapy and mitochondrial replacement) are being conducted in relevant disease models-with some progressing towards clinical trials, making mitochondrial function the focus of translational therapy research in asthma, allergy and linked metabolic syndrome.
C1 [Iyer, Divyaanka; Agrawal, Anurag] CSIR, Inst Genom & Integrat Biol, Delhi Univ Campus,Mall Rd, Delhi 110007, India.
   [Mishra, Navya] Indian Inst Publ Hlth, Gurugram, India.
   [Mishra, Navya] Chest Res Fdn, Pune, Maharashtra, India.
   [Mishra, Navya; Agrawal, Anurag] Acad Sci & Innovat Res, New Delhi, India.
C3 Council of Scientific & Industrial Research (CSIR) - India; CSIR -
   Institute of Genomics & Integrative Biology (IGIB); Academy of
   Scientific & Innovative Research (AcSIR)
RP Agrawal, A (corresponding author), CSIR, Inst Genom & Integrat Biol, Delhi Univ Campus,Mall Rd, Delhi 110007, India.; Agrawal, A (corresponding author), Acad Sci & Innovat Res, New Delhi, India.
EM a.agrawal@igib.in
RI Agrawal, Anurag/GZL-5821-2022
OI Mishra, Navya/0000-0002-3811-6418; , Divyaanka/0000-0003-3870-7418;
   Agrawal, Anurag/0000-0002-0340-5252
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NR 87
TC 43
Z9 44
U1 1
U2 17
PU CURRENT MEDICINE GROUP
PI PHILADELPHIA
PA 400 MARKET STREET, STE 700, PHILADELPHIA, PA 19106 USA
SN 1529-7322
EI 1534-6315
J9 CURR ALLERGY ASTHM R
JI Curr. Allergy Asthma Rep.
PD MAY
PY 2017
VL 17
IS 5
AR 29
DI 10.1007/s11882-017-0695-0
PG 10
WC Allergy; Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Allergy; Immunology
GA EU5OD
UT WOS:000401080800003
PM 28429306
DA 2025-06-11
ER

PT J
AU Huffman, AM
   Rezq, S
   Basnet, J
   Romero, D
AF Huffman, Alexandra M.
   Rezq, Samar
   Basnet, Jelina
   Romero, Damian
TI Biomarkers in polycystic ovary syndrome
SO CURRENT OPINION IN PHYSIOLOGY
LA English
DT Article
ID INSULIN-RESISTANCE; OXIDATIVE STRESS; NECK CIRCUMFERENCE; METABOLIC
   SYNDROME; ADOLESCENT GIRLS; ANDROGEN EXCESS; GOOD PREDICTOR; WOMEN;
   MARKERS; RISK
C1 [Huffman, Alexandra M.; Rezq, Samar; Basnet, Jelina; Romero, Damian] Univ Mississippi, Med Ctr, Dept Cell & Mol Biol, Jackson, MS 39216 USA.
   [Huffman, Alexandra M.; Rezq, Samar; Basnet, Jelina; Romero, Damian] Univ Mississippi, Mississippi Ctr Excellence Perinatal Res, Med Ctr, Jackson, MS 39216 USA.
   [Huffman, Alexandra M.; Rezq, Samar; Basnet, Jelina; Romero, Damian] Univ Mississippi, Womens Hlth Res Ctr, Med Ctr, Jackson, MS 39216 USA.
   [Huffman, Alexandra M.; Rezq, Samar; Basnet, Jelina; Romero, Damian] Univ Mississippi, Med Ctr, Cardiovasc Renal Res Ctr, Jackson, MS 39216 USA.
   [Rezq, Samar] Zagazig Univ, Fac Pharm, Dept Pharmacol & Toxicol, Zagazig, Egypt.
C3 University of Mississippi; University of Mississippi Medical Center;
   University of Mississippi; University of Mississippi Medical Center;
   University of Mississippi Medical Center; University of Mississippi;
   University of Mississippi Medical Center; University of Mississippi;
   Egyptian Knowledge Bank (EKB); Zagazig University
RP Romero, D (corresponding author), Univ Mississippi, Med Ctr, Dept Cell & Mol Biol, Jackson, MS 39216 USA.; Romero, D (corresponding author), Univ Mississippi, Mississippi Ctr Excellence Perinatal Res, Med Ctr, Jackson, MS 39216 USA.; Romero, D (corresponding author), Univ Mississippi, Womens Hlth Res Ctr, Med Ctr, Jackson, MS 39216 USA.; Romero, D (corresponding author), Univ Mississippi, Med Ctr, Cardiovasc Renal Res Ctr, Jackson, MS 39216 USA.
EM dromero@umc.ed
RI Rezq, Samar/AAL-6255-2020
FU National Institutes of Health National Institute of General Medical
   Sciences [P20GM121334]; National Institute of Diabetes and Digestive and
   Kidney Diseases [R21DK113500]; American Heart Association Predoctoral
   Fellowship [903804]; American Heart Association (AHA) [903804] Funding
   Source: American Heart Association (AHA)
FX This work was supported by National Institutes of Health National
   Institute of General Medical Sciences grant P20GM121334 (S.R. and
   D.G.R.) , and National Institute of Diabetes and Digestive and Kidney
   Diseases grant R21DK113500 (D.G.R.) . A.M.H. was supported by American
   Heart Association Predoctoral Fellowship 903804. The content is solely
   the responsibility of the authors and does not necessarily represent the
   official views of the National Institutes of Health.
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NR 57
TC 7
Z9 7
U1 0
U2 3
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
EI 2468-8673
J9 CURR OPIN PHYSIOL
JI Curr. Opin. Physiol.
PD DEC
PY 2023
VL 36
AR 100717
DI 10.1016/j.cophys.2023.100717
EA OCT 2023
PG 7
WC Physiology
WE Emerging Sources Citation Index (ESCI)
SC Physiology
GA Z3EH0
UT WOS:001110933200001
PM 37842179
OA Bronze, Green Accepted
DA 2025-06-11
ER

PT J
AU Liao, MH
   Lai, YC
   Lin, CM
AF Liao, Mao-Hung
   Lai, Ying-Ching
   Lin, Chih-Ming
TI Cardiovascular Risk Factors in Hospital Workers during the COVID-19
   Pandemic: A Hospital-Based Repeated Measures Study
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Article
DE pandemic; health care workers; cardiovascular diseases; metabolic
   syndrome; work stress
ID MENTAL-HEALTH; WORKING HOURS; PREVALENCE; STRESS
AB Although many studies have investigated burnout, stress, and mental health issues among health care workers (HCWs) during the COVID-19 pandemic, few have linked these relationships to chronic physiological illnesses such as cardiovascular diseases. This study assessed changes in cardiovascular risk factors in HCWs and other hospital workers during the COVID-19 pandemic and identified vulnerable groups at a higher risk of increased adverse cardiovascular conditions. Five hundred and fourteen hospital employees >= 20 years of age underwent physical examinations and laboratory testing once before and once after the first wave of the pandemic in Taiwan during 2020 and 2021. Their sociodemographic characteristics and cardiovascular risk factors, including blood pressure, blood biochemical parameters, and body mass index, were collected. The differences between pre- and post-pandemic measurements of their biophysical and blood biochemical parameters were analyzed using pairwise tests. The post-pandemic increases in their parameter levels and cardiovascular risk as a function of underlying factors were estimated from multivariate regressions. HCWs showed significant increases in levels and abnormal rates of BMI, blood pressure, plasma glucose, and total cholesterol after the pandemic. Post-pandemic increases in BMI, waist circumference, and blood pressure were higher in females than in males. Workers with higher levels of education or longer job tenure had greater increases in BMI, triglyceride, and total cholesterol levels than other workers. Females had a higher incidence of abnormal BMI and hypertension than males (adjusted odds ratios [AORs] of 8.3 and 2.9, respectively). Older workers' incidence of hypertension was higher than younger workers' (AOR = 3.5). Preventive strategies should be implemented for HCWs susceptible to cardiovascular diseases during emerging infectious disease outbreaks.
C1 [Liao, Mao-Hung] Yonghe Cardinal Tien Hosp, Superintendent Off, New Taipei 234, Taiwan.
   [Lai, Ying-Ching] Yonghe Cardinal Tien Hosp, Dept Med Affair, New Taipei 234, Taiwan.
   [Lai, Ying-Ching; Lin, Chih-Ming] Ming Chuan Univ, Dept Healthcare Informat & Management, Taoyuan 333, Taiwan.
C3 Ming Chuan University
RP Lin, CM (corresponding author), Ming Chuan Univ, Dept Healthcare Informat & Management, Taoyuan 333, Taiwan.
EM cmlin@mail.mcu.edu.tw
OI Lin, Chih-Ming/0000-0001-9637-395X
FU Yonghe Cardinal Tien Hospital; National Science and Technology Council; 
   [R111-01];  [111-2314-B-130-002]
FX This research was funded by the Yonghe Cardinal Tien Hospital (No.
   R111-01) and the National Science and Technology Council
   (111-2314-B-130-002).
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NR 48
TC 3
Z9 3
U1 0
U2 3
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD DEC
PY 2022
VL 19
IS 23
AR 16114
DI 10.3390/ijerph192316114
PG 11
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA 6X2US
UT WOS:000896275000001
PM 36498187
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Cristi-Montero, C
   Martínez-Flores, R
   Espinoza-Puelles, JP
   Favero-Ramirez, L
   Zurita-Corvalan, N
   Cañete, IC
   Leppe, J
   Ferrari, G
   Sadarangani, KP
   Cancino-López, J
   Hernandez-Jaña, S
   Farias, TY
   Lemes, VB
   Rodríguez-Rodríguez, F
   Brand, C
AF Cristi-Montero, Carlos
   Martinez-Flores, Ricardo
   Espinoza-Puelles, Juan Pablo
   Favero-Ramirez, Laura
   Zurita-Corvalan, Natalia
   Canete, Ignacio Castillo
   Leppe, Jaime
   Ferrari, Gerson
   Sadarangani, Kabir P.
   Cancino-Lopez, Jorge
   Hernandez-Jana, Sam
   Farias, Tuillang Yuing
   Lemes, Vanilson Batista
   Rodriguez-Rodriguez, Fernando
   Brand, Caroline
TI Study protocol and rationale of "the UP project": evaluating the
   effectiveness of active breaks on health indicators in desk-based
   workers
SO FRONTIERS IN PUBLIC HEALTH
LA English
DT Article
DE sedentary behavior; physical activity; interventions; occupational
   health; cardiometabolic risk
ID PHYSICAL-ACTIVITY; SEDENTARY BEHAVIOR; X-RAY; CARDIOMETABOLIC RISK;
   MEDITERRANEAN DIET; BODY-COMPOSITION; SITTING TIME; ADULTS;
   ASSOCIATIONS; INACTIVITY
AB Background: Excessive sedentary time has been negatively associated with several health outcomes, and physical activity alone does not seem to fully counteract these consequences. This panorama emphasizes the essential of sedentary time interruption programs. "The Up Project" seeks to assess the effectiveness of two interventions, one incorporating active breaks led by a professional and the other utilizing a computer application (self-led), of both equivalent duration and intensity. These interventions will be compared with a control group to evaluate their impact on physical activity levels, sedentary time, stress perception, occupational pain, and cardiometabolic risk factors among office workers. Methods: This quasi-experimental study includes 60 desk-based workers from universities and educational institutes in Valparaiso, Chile, assigned to three groups: (a) booster breaks led by professionals, (b) computer prompts that are unled, and (c) a control group. The intervention protocol for both experimental groups will last 12 weeks (only weekdays). The following measurements will be performed at baseline and post-intervention: cardiometabolic risk based on body composition (fat mass, fat-free mass, and bone mass evaluated by DXA), waist circumference, blood pressure, resting heart rate, and handgrip strength. Physical activity and sedentary time will be self-reported and device-based assessed using accelerometry. Questionnaires will be used to determine the perception of stress and occupational pain. Discussion: Governments worldwide are addressing health issues associated with sedentary behavior, particularly concerning individuals highly exposed to it, such as desk-based workers. Despite implementing certain strategies, there remains a noticeable gap in comprehensive research comparing diverse protocols. For instance, studies that contrast the outcomes of interventions led by professionals with those prompted by computers are scarce. This ongoing project is expected to contribute to evidence-based interventions targeting reduced perceived stress levels and enhancing desk-based employees' mental and physical well-being. The implications of these findings could have the capacity to lay the groundwork for future public health initiatives and government-funded programs.
C1 [Cristi-Montero, Carlos; Martinez-Flores, Ricardo; Espinoza-Puelles, Juan Pablo; Favero-Ramirez, Laura; Zurita-Corvalan, Natalia; Canete, Ignacio Castillo; Hernandez-Jana, Sam; Rodriguez-Rodriguez, Fernando; Brand, Caroline] Pontificia Univ Catolica Valparaiso, Phys Educ Sch, IRyS Grp, Valparaiso, Chile.
   [Leppe, Jaime] Univ Desarrollo, Sch Phys Therapy, Clin Alemana, Fac Med, Santiago, Chile.
   [Ferrari, Gerson] Univ Santiago Chile USACH, Escuela Ciencias Act Fis & Deporte & Salud, Santiago, Chile.
   [Ferrari, Gerson] Univ Autonoma Chile, Fac Ciencias Salud, Santiago, Chile.
   [Sadarangani, Kabir P.] Univ Autonoma Chile, Santiago, Chile.
   [Sadarangani, Kabir P.] Univ Diego Portales, Escuela Kinesiol, Fac Salud & Odontol, Santiago, Chile.
   [Cancino-Lopez, Jorge] Univ Finis Terrae Santiago, Escuela Kinesiol, Fac Med, Lab Fisiol Ejercicio & Metab, Santiago, Chile.
   [Farias, Tuillang Yuing] Univ Santo Tomas, Escuela Kinesiol, Vina Del Mar, Chile.
   [Lemes, Vanilson Batista] Univ Fed Rio Grande Do Sul, Escola Educ Fis Fisioterapia & Danca, Porto Alegre, Brazil.
C3 Pontificia Universidad Catolica de Valparaiso; Clinica Alemana;
   Universidad del Desarrollo; Universidad de Santiago de Chile;
   Universidad Autonoma de Chile; Universidad Autonoma de Chile; University
   Diego Portales; Universidad Santo Tomas; Universidade Federal do Rio
   Grande do Sul
RP Cristi-Montero, C (corresponding author), Pontificia Univ Catolica Valparaiso, Phys Educ Sch, IRyS Grp, Valparaiso, Chile.
EM carlos.cristi.montero@gmail.com
RI Cristi-Montero, Carlos/AAE-4945-2020; Ferrari, Gerson/HHM-6173-2022;
   Leppe, Jaime/G-4837-2016; Brand, Caroline/ABH-5856-2020; Zurita,
   Natalia/KBP-7211-2024; Cancino-López, Jorge/AAX-3079-2021; RODRIGUEZ,
   FERNANDO/F-2842-2016; Batista Lemes, Vanilson/A-4505-2019
OI RODRIGUEZ, FERNANDO/0000-0002-4999-4857; Batista Lemes,
   Vanilson/0000-0003-3298-4449
FU ANID BECAS Magister Nacional [51852023]
FX The author(s) declare that financial support was received for the
   research, authorship, and/or publication of this article. RM-F was
   supported by a grant from ANID BECAS Magister Nacional (No 51852023).
   This work is part of a master's degree thesis conducted by RM-F in
   Physical Activity for Health of the Pontificia Universidad Catolica de
   Valparaiso, Chile.
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NR 82
TC 0
Z9 0
U1 0
U2 6
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 2296-2565
J9 FRONT PUBLIC HEALTH
JI Front. Public Health
PD MAR 19
PY 2024
VL 12
AR 1363015
DI 10.3389/fpubh.2024.1363015
PG 10
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA MP9W2
UT WOS:001194956800001
PM 38566792
OA gold, Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Mindikoglu, AL
   Opekun, AR
   Gagan, SK
   Devaraj, S
AF Mindikoglu, Ayse L.
   Opekun, Antone R.
   Gagan, Sood K.
   Devaraj, Sridevi
TI Impact of Time-Restricted Feeding and Dawn-to-Sunset Fasting on
   Circadian Rhythm, Obesity, Metabolic Syndrome, and Nonalcoholic Fatty
   Liver Disease
SO GASTROENTEROLOGY RESEARCH AND PRACTICE
LA English
DT Review
ID DIET-INDUCED OBESITY; UNITED-STATES; GUT MICROBIOTA;
   HEPATOCELLULAR-CARCINOMA; PERIPHERAL CLOCKS; OXIDATIVE STRESS;
   BODY-COMPOSITION; LIPID PROFILE; RAMADAN; MELATONIN
AB Obesity now affects millions of people and places them at risk of developing metabolic syndrome, nonalcoholic fatty liver disease (NAFLD), and even hepatocellular carcinoma. This rapidly emerging epidemic has led to a search for cost-effective methods to prevent the metabolic syndrome and NAFLD as well as the progression of NAFLD to cirrhosis and hepatocellular carcinoma. In murine models, time-restricted feeding resets the hepatic circadian clock and enhances transcription of key metabolic regulators of glucose and lipid homeostasis. Studies of the effect of dawn-to-sunset Ramadan fasting, which is akin to time-restricted feeding model, have also identified significant improvement in body mass index, serum lipid profiles, and oxidative stress parameters. Based on the findings of studies conducted on human subjects, dawn-to-sunset fasting has the potential to be a cost-effective intervention for obesity, metabolic syndrome, and NAFLD.
C1 [Mindikoglu, Ayse L.; Gagan, Sood K.] Baylor Coll Med, Michael E DeBakey Dept Surg, Div Abdominal Transplantat, Houston, TX 77030 USA.
   [Mindikoglu, Ayse L.; Opekun, Antone R.] Baylor Coll Med, Dept Med, Sect Gastroenterol & Hepatol, Houston, TX 77030 USA.
   [Opekun, Antone R.] Baylor Univ, Dept Pediat, Div Gastroenterol Nutr & Hepatol, Houston, TX 77030 USA.
   [Devaraj, Sridevi] Baylor Coll Med, Texas Childrens Hosp, Clin Chem & Point Care Technol, Houston, TX 77030 USA.
   [Devaraj, Sridevi] Baylor Coll Med, Dept Pathol & Immunol, Hlth Ctr, Houston, TX 77030 USA.
C3 Baylor College of Medicine; Baylor College of Medicine; Baylor
   University; Baylor College of Medicine; Baylor College Medical Hospital;
   Baylor College of Medicine
RP Mindikoglu, AL (corresponding author), Baylor Coll Med, Michael E DeBakey Dept Surg, Div Abdominal Transplantat, Houston, TX 77030 USA.; Mindikoglu, AL (corresponding author), Baylor Coll Med, Dept Med, Sect Gastroenterol & Hepatol, Houston, TX 77030 USA.
EM ayse.mindikoglu@bcm.edu
RI Mindikoglu, Ayse/HOF-9696-2023
OI devaraj, sridevi/0000-0001-9189-7914; Mindikoglu,
   Ayse/0000-0003-4598-8692
FU NIH Public Health Service, Texas Medical Center Digestive Disease Center
   [P30DK056338]
FX This project was supported in part by NIH Public Health Service grant
   P30DK056338, which funds the Texas Medical Center Digestive Disease
   Center. The contents of this manuscript are solely the responsibility of
   the authors and do not necessarily represent the official views of the
   National Institute of Diabetes and Digestive and Kidney Diseases or the
   NIH. The authors thank David Y. Graham, M.D., M.A.C.G. (Professor of
   Medicine, Molecular Virology and Microbiology, Department of Medicine,
   Division of Gastroenterology and Hepatology, Baylor College of Medicine)
   for editing our manuscript and for his valuable input.
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NR 111
TC 32
Z9 32
U1 1
U2 28
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1687-6121
EI 1687-630X
J9 GASTROENT RES PRACT
JI Gastroenterol. Res. Pract.
PY 2017
VL 2017
AR 3932491
DI 10.1155/2017/3932491
PG 13
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA FM9TQ
UT WOS:000415614700001
PM 29348746
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Kurata, A
   Nishizawa, H
   Kihara, S
   Maeda, N
   Sonoda, M
   Okada, T
   Ohashi, K
   Hibuse, T
   Fujita, K
   Yasui, A
   Hiuge, A
   Kumada, M
   Kuriyama, H
   Shimomura, I
   Funahashi, T
AF Kurata, A.
   Nishizawa, H.
   Kihara, S.
   Maeda, N.
   Sonoda, M.
   Okada, T.
   Ohashi, K.
   Hibuse, T.
   Fujita, K.
   Yasui, A.
   Hiuge, A.
   Kumada, M.
   Kuriyama, H.
   Shimomura, I.
   Funahashi, T.
TI Blockade of angiotensin II type-1 receptor reduces oxidative stress in
   adipose tissue and ameliorates adipocytokine dysregulation
SO KIDNEY INTERNATIONAL
LA English
DT Article
DE angiotensin II type 1 receptor blocker; adiponectin; adipocytokine;
   oxidative stress; NADPH oxidase
ID NECROSIS-FACTOR-ALPHA; METABOLIC SYNDROME; DIABETIC-NEPHROPATHY;
   ESSENTIAL-HYPERTENSION; NITRIC-OXIDE; ARTERIOSCLEROTIC OUTCOMES;
   CARDIOVASCULAR MORBIDITY; INSULIN SENSITIVITY; 3T3-L1 ADIPOCYTES;
   VASCULAR-DISEASE
AB Dysregulated production of adipocytokines may be involved in the development of atherosclerotic cardiovascular disease in metabolic syndrome and chronic kidney disease ( CKD) associated with metabolic syndrome. The aim of this study was to determine the effects of treatment with angiotensin II ( Ang II) type-1 receptor blocker ( ARB) on the regulation of adipocytokines. Olmesartan, an ARB, significantly blunted the age- and body weight-associated falls in plasma adiponectin both in genetically and diet-induced obese mice, without affecting body weight, but had no effect on plasma adiponectin levels in lean mice. Olmesartan also ameliorated dysregulation of adipocytokines in obesity, such as tumor necrosis factor-alpha, plasminogen activator inhibitor-1, monocyte chemotactic protein-1, and serum amyloid A3. Olmesartan significantly reduced reactive oxygen species originating from accumulated fat and attenuated the expression of nicotinamide adenine dinucleotide phospho hydrogenase oxidase subunits in adipose tissue. In cultured adipocytes, olmesartan acted as an antioxidant and improved adipocytokine dysregulation. Our results indicate that blockade of Ang II receptor ameliorates adipocytokine dysregulation and that such action is mediated, at least in part, by targeting oxidative stress in obese adipose tissue. Ang II signaling and subsequent oxidative stress in adipose tissue may be potential targets for the prevention of atherosclerotic cardiovascular disease in metabolic syndrome and also in metabolic syndrome-based CKD.
C1 Osaka Univ, Grad Sch Med, Dept Metab Med, Suita, Osaka 5650871, Japan.
C3 The University of Osaka
RP Nishizawa, H (corresponding author), Osaka Univ, Grad Sch Med, Dept Metab Med, 2-2-B5 Yamadaoka, Suita, Osaka 5650871, Japan.
EM hitoshin@imed2.med.osaka-u.ac.jp
RI Maeda, Norikazu/LZI-4561-2025; OHASHI, Koji/I-7307-2014
OI Yasui, Atsutaka/0000-0003-4903-7210
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NR 60
TC 140
Z9 156
U1 0
U2 4
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0085-2538
EI 1523-1755
J9 KIDNEY INT
JI Kidney Int.
PD NOV
PY 2006
VL 70
IS 10
BP 1717
EP 1724
DI 10.1038/sj.ki.5001810
PG 8
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 104DO
UT WOS:000241936500011
PM 16985520
OA Bronze
DA 2025-06-11
ER

PT J
AU Gleicher, S
   Byler, T
   Ginzburg, N
AF Gleicher, Stephanie
   Byler, Timothy
   Ginzburg, Natasha
TI Association Between Stress Urinary Incontinence and the Components of
   Metabolic Syndrome Among Females 20-59 Years
SO UROLOGY
LA English
DT Article
ID QUALITY-OF-LIFE; RISK-FACTORS; WOMEN; PREVALENCE; SYMPTOMS; OBESITY;
   SWEDEN; HEALTH
AB OBJECTIVE To assess the relationship between stress urinary incontinence (SUI) and metabolic syndrome among a population-based cohort of women 20-59 years.
   METHODS National Health and Nutrition Examination Survey database was used between the years of 2013 and 2016 and included women aged 20-59 years. SUI was defined as "Urinary leakage with physical activity." Metabolic syndrome was defined as >2 risk factors: fasting blood glucose (FBG) >99 mg/dL, triglyceride >149 mg/dL, high-density lipoprotein <50 mg/dL, waistline >88 cm, and blood pressure >130/85. We generated weighted estimated prevalence and ran multivariable logistic regression models.
   RESULTS Among 3430 female subjects, the estimated prevalence of SUI was 38.7% (95% confidence interval [CI] 36.7-40.7%) and metabolic syndrome was 10.2% (95% CI 8.9-11.6). Higher rates of SUI were seen with large waistlines, elevated FBG, and elevated triglycerides. Among women with metabolic syndrome, 56.1% (95% CI 39.7-49.0%) had SUI. Among all women, metabolic syndrome and elevated FBG significantly increase the risk of SUI (odds ratio [OR] 1.53 [95% CI 1.02-2.28] and OR 1.86 [95% CI 1.14-3.03], respectively). In women 20-39 years, a large waistline significantly increased the risk of SUI (OR 1.72 [95% CI 1.00-2.99]).
   CONCLUSION Among females 20-59 years in the United States, 38.7% report SUI and 10% have metabolic syndrome. Metabolic syndrome and an elevated FBG significantly increase the risk of SUI among all women. A large waistline increases the risk of SUI in women aged 20-39 years. Weight loss and adequate control of metabolic syndrome should be considered key strategies in the management of SUI. (C) 2020 Elsevier Inc.
C1 [Gleicher, Stephanie; Byler, Timothy; Ginzburg, Natasha] SUNY Upstate Med Univ, Dept Urol, 750 East Adams St, Syracuse, NY 13210 USA.
C3 State University of New York (SUNY) System; State University of New York
   (SUNY) Upstate Medical Center
RP Ginzburg, N (corresponding author), SUNY Upstate Med Univ, Dept Urol, 750 East Adams St, Syracuse, NY 13210 USA.
EM GinzburN@upstate.edu
RI Gleicher, Stephanie/JFA-1235-2023
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NR 29
TC 8
Z9 8
U1 0
U2 4
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0090-4295
EI 1527-9995
J9 UROLOGY
JI Urology
PD NOV
PY 2020
VL 145
BP 100
EP 105
DI 10.1016/j.urology.2020.07.028
PG 6
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA OP0XZ
UT WOS:000587806900023
PM 32735979
DA 2025-06-11
ER

PT J
AU Akimov, OY
   Mykytenko, AO
   Kostenko, VO
   Yeroshenko, GA
AF Akimov, O. Y.
   Mykytenko, A. O.
   Kostenko, V. O.
   Yeroshenko, G. A.
TI THE INFLUENCE OF STIMULATION OF ORGANISM WITH BACTERIAL
   LIPOPOLYSACCHARIDE ON THE BACKGROUND OF METABOLIC SYNDROME MODELING ON
   THE DEVELOPMENT OF OXIDATIVE STRESS IN RAT HEART
SO WORLD OF MEDICINE AND BIOLOGY
LA English
DT Article
DE metabolic syndrome; heart; rats; bacterial lipopolysaccharide; oxidative
   stress
ID LIVER
AB Metabolic syndrome is one of the most widespread non-infectious pathologies in the world affecting almost a quarter of world population. The purpose of this work is to determine the activity of antioxidant enzymes, the production of superoxide anion radical, the content of oxidatively modified proteins and the concentration of malondialdehyde in the heart of rats under conditions of experimental metabolic syndrome and stimulation of the organism with bacterial lipopolysaccharide. In the test group of animals superoxide production increased by 6.31 times, activity of superoxide dismutase decreased by 2.97 times, the activity of catalase decreased by 2.4 times, the concentration of malondialdehyde increased by 3.08 times, and the content of oxidatively modified proteins increased by 2.81 times. Stimulation of organism with bacterial lipopolysaccharide on the background of induction of metabolic syndrome by high fructose diet shows synergetic effect on increase of reactive oxygen species production, severely decreases activity of antioxidant enzymes and intensifies oxidative damage to protein and lipid structures of rat heart.
C1 [Akimov, O. Y.; Mykytenko, A. O.; Kostenko, V. O.; Yeroshenko, G. A.] Poltava State Med Univ, Poltava, Ukraine.
C3 Poltava State Medical University
RP Akimov, OY (corresponding author), Poltava State Med Univ, Poltava, Ukraine.
EM o.akimov@pdmu.edu.ua
RI Yeroshenko, Galina/AAH-5312-2019; Mykytenko, Andrii/HJZ-1628-2023;
   Akimov, Oleh/AAJ-7809-2021
CR Ahmed M, 2022, J DIABETES METAB DIS, V21, P1011, DOI 10.1007/s40200-021-00965-2
   Corbi-Cobo-Losey MJ, 2023, ANTIOXIDANTS-BASEL, V12, DOI 10.3390/antiox12030686
   Dai SS, 2021, FRONT CELL DEV BIOL, V9, DOI 10.3389/fcell.2021.779432
   Gargiulo P, 2020, HEART FAIL REV, V25, P1, DOI 10.1007/s10741-019-09838-6
   Jiang QX, 2021, ENVIRON POLLUT, V288, DOI 10.1016/j.envpol.2021.117792
   Li JY, 2022, OXID MED CELL LONGEV, V2022, DOI 10.1155/2022/9196232
   Lin X, 2020, J INT MED RES, V48, DOI 10.1177/0300060519826848
   Liu YW, 2020, OXID MED CELL LONGEV, V2020, DOI 10.1155/2020/5384909
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   Mykytenko AO, 2022, WORLD MED BIOL, V79, P214, DOI 10.26724/2079-8334-2022-1-79-214-217
   Nicoara DM, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms24098414
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   Wieckowska-Gacek A, 2021, AGEING RES REV, V70, DOI 10.1016/j.arr.2021.101397
NR 14
TC 0
Z9 0
U1 0
U2 0
PU SCIENTIFIC SOC ANATOMISTS HISTOLOGISTS & EMBRYOLOGISTS UKRAINE
PI POLTAVA
PA VUL SHEVCHENKA 23, POLTAVA, 36024, UKRAINE
SN 2079-8334
J9 WORLD MED BIOL
JI World Med. Biol.
PY 2023
VL 84
IS 2
BP 176
EP 180
DI 10.26724/2079-8334-2023-2-84-176-180
PG 5
WC Medicine, Research & Experimental
WE Emerging Sources Citation Index (ESCI)
SC Research & Experimental Medicine
GA O2ND2
UT WOS:001042229500036
DA 2025-06-11
ER

PT J
AU Barghandan, N
   Dolatkhah, N
   Eslamian, F
   Ghafarifar, N
   Hashemian, M
AF Barghandan, Nasibeh
   Dolatkhah, Neda
   Eslamian, Fariba
   Ghafarifar, Nahal
   Hashemian, Maryam
TI Association of depression, anxiety and menopausal-related symptoms with
   demographic, anthropometric and body composition indices in healthy
   postmenopausal women
SO BMC WOMENS HEALTH
LA English
DT Article
DE Menopause; Anxiety; Depression
ID SKELETAL-MUSCLE MASS; QUALITY-OF-LIFE; HOT FLASHES; PHYSICAL-ACTIVITY;
   MIDLIFE WOMEN; RISK-FACTORS; WAIST CIRCUMFERENCE; METABOLIC SYNDROME;
   MOOD DISORDERS; OBESITY
AB Background The termination of the menstrual cycle is correlated with a number of physiological alterations and symptoms that can negatively impact emotion and mood. We aimed to investigate the association of anxiety, depression, and menopausal related symptoms with demographic, anthropometric, and body composition indices in healthy postmenopausal women. Methods A total of 320 menopausal women were selected randomly from referrals of health centers between January and June 2018 in Tabriz/Iran. All participants completed a demographic questionnaire. Bioelectrical impedance analysis was applied to evaluate body fat mass (BFM), soft lean mass (SLM), and lean body mass (LBM) of participants. The modified Kupperman index, Beck's depression inventory-II, and Spielberger's state-trait anxiety inventory were applied to measure the severity of menopausal-related symptoms, the frequency, and severity of the symptoms of depression and state (SA) and trait anxiety (TA), respectively. Results Finally, 245 postmenopausal women with age of 55.33 +/- 4.48 years and body mass index (BMI) of 27.96 +/- 3.22 kg/m(2) were studied. Women with the age of 55 years and older (OR 3.928, 95% CI 1.504-10.256) and also women with mild physical activity (OR 10.104, 95% CI 3.785-26.976) had a greater possibility of having mild and moderate depression in comparison with women less than 50 years old and women with moderate and severe physical activity. Moderate and severe physical activity was correlated with a lower possibility of having medium upward, relatively severe and severe TA in comparison with participants with mild physical activity in these women (OR 0.372, 95% CI 0.151-0.917). Women with higher BMI and BFM had and more severe menopause-related symptoms (r = 0.143, p = 0.025 and r = 0.139, p = 0.030, respectively) and more severe TA symptoms (r = 0.198, p = 0.018 and r = 0.151, p = 0.021, respectively). Women with lower LBM (r = - 0.139, p = 0.031) and lower SLM (r = - 0.128, p = 0.047) had more severe depressive symptoms. Conclusion Postmenopausal women with higher age and lower physical activity had a greater possibility of having mild and moderate depression. Lower physical activity was also correlated with a greater possibility of having medium upward to severe TA symptoms. Postmenopausal women with higher BMI and BFM had more severe menopause-related and TA symptoms. Women with lower LBM and SLM had more severe depressive symptoms.
C1 [Barghandan, Nasibeh] Islamic Azad Univ Ahar, Ahar, Iran.
   [Dolatkhah, Neda] Tabriz Univ Med Sci, Aging Res Inst, Emam Reza Hosp, Phys Med & Rehabil Res Ctr, Azadi Ave, Golgasht, Tabriz, Iran.
   [Eslamian, Fariba] Tabriz Univ Med Sci, Aging Res Inst, Phys Med & Rehabil Res Ctr, Tabriz, Iran.
   [Ghafarifar, Nahal] Tabriz Univ Med Sci, Dept Phys Med & Rehabil, Fac Med, Tabriz, Iran.
   [Hashemian, Maryam] Utica Coll, Dept Biol, Sch Art & Sci, Utica, NY 13502 USA.
C3 Islamic Azad University; Tabriz University of Medical Science; Tabriz
   University of Medical Science; Tabriz University of Medical Science
RP Dolatkhah, N (corresponding author), Tabriz Univ Med Sci, Aging Res Inst, Emam Reza Hosp, Phys Med & Rehabil Res Ctr, Azadi Ave, Golgasht, Tabriz, Iran.
EM neda_dolatkhah@yahoo.com
RI Eslamian, Fariba/L-7751-2017; Hashemian, Maryam/I-1307-2013
FU Physical Medicine and Rehabilitation Research Center of Tabriz
   University of Medical Sciences, Tabriz, Iran
FX This study is supported financially by Physical Medicine and
   Rehabilitation Research Center of Tabriz University of Medical Sciences,
   Tabriz, Iran. The funding body did not have any role in the design of
   the study or collection, analysis, or interpretation of data and also in
   writing of the manuscript.
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NR 84
TC 13
Z9 13
U1 4
U2 14
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1472-6874
J9 BMC WOMENS HEALTH
JI BMC Womens Health
PD MAY 7
PY 2021
VL 21
IS 1
AR 192
DI 10.1186/s12905-021-01338-w
PG 12
WC Public, Environmental & Occupational Health; Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; Obstetrics & Gynecology
GA SK8TM
UT WOS:000656491600001
PM 33962601
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Yiginer, O
   Ozcelik, F
   Inanc, T
   Aparci, M
   Ozmen, N
   Cingozbay, BY
   Kardesoglu, E
   Suleymanoglu, S
   Sener, G
   Cebeci, BS
AF Yiginer, Omer
   Ozcelik, Fatih
   Inanc, Tugrul
   Aparci, Mustafa
   Ozmen, Namik
   Cingozbay, Bekir Yilmaz
   Kardesoglu, Ejder
   Suleymanoglu, Selami
   Sener, Goksel
   Cebeci, Bekir Sitki
TI Allopurinol improves endothelial function and reduces
   oxidant-inflammatory enzyme of myeloperoxidase in metabolic syndrome
SO CLINICAL RESEARCH IN CARDIOLOGY
LA English
DT Article
DE metabolic syndrome; allopurinol; myeloperoxidase; endothelial
   dysfunction; C-reactive protein
ID SERUM URIC-ACID; C-REACTIVE PROTEIN; XANTHINE-OXIDASE; HYPOCHLOROUS
   ACID; OXIDATIVE STRESS; DYSFUNCTION; HEART; ATHEROSCLEROSIS; RISK;
   ASSOCIATION
AB Objective In this study, we tested in patients with metabolic syndrome whether allopurinol through decreasing oxidative stress improves endothelial function, and ameliorates inflammatory state represented by markers of myeloperoxidase, C-reactive protein (CRP) and fibrinogen. Methods In a randomized, double-blind fashion; subjects with metabolic syndrome were treated with allopurinol (n = 28) or placebo (n = 22) for one month. Before and after treatment, blood samples were collected and the flow-mediated dilation (FMD) and isosorbide dinitrate (ISDN)-mediated dilation of the brachial artery were performed. Results Baseline clinical characteristics of the allopurinol and placebo groups demonstrated no differences in terms of clinical characteristics, endothelial function and inflammatory markers. After the treatment with allopurinol, FMD was increased from 8.0 +/- 0.5 % to 11.8 +/- 0.6% (P < 0.01), but there were no change in the placebo group. In both groups, ISDN-mediated dilation is unaffected by the treatment. As a marker of oxidative stress, allopurinol significantly reduced malondialdehyde. Moreover, myeloperoxidase levels were reduced by the treatment with allopurinol (56.1 +/- 3.4 ng/ml vs. 44.4 +/- 2.4 ng/ml, P < 0.05) but there were no change in the placebo group. Surprisingly, neither CRP nor fibrinogen levels were affected by the treatment in both groups. Conclusion Xanthine oxidoreductase inhibition by allopurinol in patients with metabolic syndrome reduces oxidative stress, improves endothelial function, ameliorates myeloperoxidase levels and does not have any effect on CRP and fibrinogen levels.
C1 [Yiginer, Omer] Gumussuyu Asker Hastanesi, Kardiyol Klin, TR-34437 Istanbul, Turkey.
   [Yiginer, Omer; Ozcelik, Fatih; Inanc, Tugrul] Gumussuyu Mil Hosp, Istanbul, Turkey.
   [Aparci, Mustafa; Ozmen, Namik; Cingozbay, Bekir Yilmaz; Kardesoglu, Ejder; Suleymanoglu, Selami; Cebeci, Bekir Sitki] GMMA Haydarpasa Teaching Hosp, Istanbul, Turkey.
   [Sener, Goksel] Marmara Univ, Sch Pharm, Dept Pharmacol, Istanbul, Turkey.
C3 Gumussuyu Military Hospital; Gumussuyu Military Hospital; Istanbul
   Haydarpasa Sultan Abdulhamid Training & Research Hospital; Gulhane
   Military Medical Academy; Marmara University
RP Yiginer, O (corresponding author), Gumussuyu Asker Hastanesi, Kardiyol Klin, TR-34437 Istanbul, Turkey.
EM oyiginer@yahoo.com
RI Yiğiner, Ömer/AAO-2477-2020; Şener, Göksel/AAN-4461-2021
OI Sener, Goksel/0000-0001-7444-6193; Ozmen, Namik/0000-0002-1168-0940
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NR 34
TC 73
Z9 79
U1 0
U2 25
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1861-0684
EI 1861-0692
J9 CLIN RES CARDIOL
JI Clin. Res. Cardiol.
PD MAY
PY 2008
VL 97
IS 5
BP 334
EP 340
DI 10.1007/s00392-007-0636-3
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 301BD
UT WOS:000255870500008
PM 18330493
DA 2025-06-11
ER

PT J
AU Whittaker, KS
   Krantz, DS
   Rutledge, T
   Johnson, BD
   Wawrzyniak, AJ
   Bittner, V
   Eastwood, JA
   Eteiba, W
   Cornell, CE
   Pepine, CJ
   Vido, DA
   Handberg, E
   Merz, CNB
AF Whittaker, Kerry S.
   Krantz, David S.
   Rutledge, Thomas
   Johnson, B. Delia
   Wawrzyniak, Andrew J.
   Bittner, Vera
   Eastwood, Jo-Ann
   Eteiba, Wafia
   Cornell, Carol E.
   Pepine, Carl J.
   Vido, Diane A.
   Handberg, Eileen
   Merz, C. Noel Bairey
TI Combining Psychosocial Data to Improve Prediction of Cardiovascular
   Disease Risk Factors and Events: The National Heart, Lung, and Blood
   Institute-Sponsored Women's Ischemia Syndrome Evaluation Study
SO PSYCHOSOMATIC MEDICINE
LA English
DT Article
DE women; cardiovascular disease; psychosocial variables; factor analysis;
   cardiovascular events
ID CORONARY-ARTERY-DISEASE; SOCIAL SUPPORT; MYOCARDIAL-INFARCTION;
   METABOLIC SYNDROME; ATHEROSCLEROSIS RISK; CHEST PAIN; DEPRESSION;
   HOSTILITY; ANXIETY; ANGER
AB Background: There is overlap among psychosocial predictors of cardiovascular disease (CVD). The usefulness of combining psychosocial variables as risk markers for CVD needs investigation. Methods: Participants were 493 women in the NHLBI WISE study. Multivariate combination of Beck Depression Inventory (BDI), State-Trait Anxiety Inventory (STAI), Social Network Index (SNI), and Cook-Medley hostility subscales was evaluated, and principal components analysis also conducted. Relationships of composite psychosocial risk markers to CVD events and risk factors were assessed. Results: The multivariate block of SNI, Cook-Medley Hostile Affect subscale, STAI, and BDI predicted CVD events (chi(2) = 27.8, df = 6, p < .001). Scalewise factor analysis revealed 2 factors: negative affectivity (NA) and hostility (explained variance, 45.6% and 17.1%, respectively). NA was associated with BMI (beta [SE] = 0.18 [0.09], p =.04), hostility with metabolic syndrome (exp(beta) = 0.60 [0.28], p =.04). Both factors were associated with blood pressure (BP): NA with SBP (beta = 2.53 [1.04], p =.02) and DBP (beta = 1.66 [0.60], p =.02); hostility with SBP (beta = 2.72 [1.13], p =.02) and DBP (beta = 1.83 [0.65], p =.005). Neither factor predicted CVD events. Original scales predicted CVD events: lower SNI (HR = 0.74, Cl = 0.57-0.96), lower Hostile Affect (HR = 0.80, CI = 0.56-1.03), and higher BDI (HR = 1.33, Cl = 1.08-1.74). Conclusions: In women with suspected ischemia, multivariate combination of psychosocial risk markers predicts CVD events; derived psychosocial factors were associated with CVD risk factors but not events. Measuring common variance among psychosocial variables may be a useful research strategy.
C1 [Whittaker, Kerry S.; Krantz, David S.; Wawrzyniak, Andrew J.] Uniformed Serv Univ Hlth Sci, Dept Med & Clin Psychol, Bethesda, MD 20814 USA.
   [Rutledge, Thomas] VA San Diego Healthcare Syst, San Diego, CA USA.
   [Eastwood, Jo-Ann] Univ Calif Los Angeles, Sch Nursing, Los Angeles, CA USA.
   [Eastwood, Jo-Ann; Merz, C. Noel Bairey] Cedars Sinai Heart Inst, Womens Heart Ctr, Los Angeles, CA USA.
   [Johnson, B. Delia; Eteiba, Wafia] Univ Pittsburgh, Grad Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA USA.
   [Vido, Diane A.] Allegheny Gen Hosp, Pittsburgh, PA 15212 USA.
   [Bittner, Vera] Univ Alabama Birmingham, Birmingham, AL USA.
   [Cornell, Carol E.] Univ Arkansas Med Sci, Dept Hlth Behav & Hlth Educ, Little Rock, AR 72205 USA.
   [Pepine, Carl J.; Handberg, Eileen] Univ Florida, Dept Med, Div Cardiol, Gainesville, FL USA.
C3 Uniformed Services University of the Health Sciences - USA; US
   Department of Veterans Affairs; Veterans Health Administration (VHA); VA
   San Diego Healthcare System; University of California System; University
   of California Los Angeles; Cedars Sinai Medical Center; Pennsylvania
   Commonwealth System of Higher Education (PCSHE); University of
   Pittsburgh; Allegheny Health Network; Allegheny General Hospital;
   University of Alabama System; University of Alabama Birmingham;
   University of Arkansas System; University of Arkansas Medical Sciences;
   State University System of Florida; University of Florida
RP Krantz, DS (corresponding author), Uniformed Serv Univ Hlth Sci, Dept Med & Clin Psychol, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA.
EM dskrantz@usuhs.mil
RI Krantz, David/L-5364-2015
OI Bittner, Vera/0000-0001-9456-850X; Krantz, David/0000-0002-1671-1355;
   Handberg, Eileen/0000-0002-7805-9577
FU National Heart, Lung, and Blood Institute [N01-HV-68161, N01-HV-68162,
   N01-HV-68163, N01-HV-68164]; Gustavus and Louis Pfeiffer Research
   Foundation, Danville, New Jersey; Women's Guild of Cedars-Sinai Medical
   Center, Los Angeles, California; Ladies Hospital Aid Society of Western
   Pennsylvania, Pittsburgh, Pennsylvania; QMED, Inc, Laurence Harbor, New
   Jersey; Cedars-Sinai Medical Center, Los Angeles, California; 
   [U0164829];  [U01 HL649141];  [U01 HL649241];  [T32HL69751];  [BETRHEART
   5RO1HL085730]
FX This work was supported by contracts from the National Heart, Lung, and
   Blood Institute (nos. N01-HV-68161, N01-HV-68162, N01-HV-68163, and
   N01-HV-68164); Grants U0164829, U01 HL649141, U01 HL649241, T32HL69751,
   and BETRHEART 5RO1HL085730; and grants from the Gustavus and Louis
   Pfeiffer Research Foundation, Danville, New Jersey; the Women's Guild of
   Cedars-Sinai Medical Center, Los Angeles, California; the Ladies
   Hospital Aid Society of Western Pennsylvania, Pittsburgh, Pennsylvania;
   QMED, Inc, Laurence Harbor, New Jersey; the Edythe L. Broad Women's
   Heart Research Fellowship, Cedars-Sinai Medical Center, Los Angeles,
   California; and the Barbra Streisand Women's Cardiovascular Research and
   Education Program, Cedars-Sinai Medical Center, Los Angeles, California.
CR [Anonymous], PRACT ASSESS RES EVA
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NR 42
TC 21
Z9 24
U1 0
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0033-3174
EI 1534-7796
J9 PSYCHOSOM MED
JI Psychosom. Med.
PD APR
PY 2012
VL 74
IS 3
BP 263
EP 270
DI 10.1097/PSY.0b013e31824a58ff
PG 8
WC Psychiatry; Psychology; Psychology, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry; Psychology
GA 930JS
UT WOS:000303136300005
PM 22434916
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Kim, D
   Yoo, ER
   Li, AA
   Tighe, SP
   Cholankeril, G
   Harrison, SA
   Ahmed, A
AF Kim, Donghee
   Yoo, Eric R.
   Li, Andrew A.
   Tighe, Sean P.
   Cholankeril, George
   Harrison, Stephen A.
   Ahmed, Aijaz
TI Depression is associated with non-alcoholic fatty liver disease among
   adults in the United States
SO ALIMENTARY PHARMACOLOGY & THERAPEUTICS
LA English
DT Article
ID EXTERNAL VALIDATION; METABOLIC SYNDROME; NATIONAL-HEALTH; RISK-FACTOR;
   FIBROSIS; ANXIETY; PREVALENCE; MORTALITY; BURDEN; SEVERITY
AB Background Currently, the relationship between depression and non-alcoholic fatty liver disease (NAFLD) is not clearly defined. Aim To determine whether depression is associated with NAFLD and NAFLD-related advanced fibrosis in a large population sample. Methods We performed a cross-sectional analysis using the 2007-2016 National Health and Nutrition Examination Survey database among adults (20 years or older) in the United States (US). Depression and functional impairment due to depression were assessed with the Patient Health Questionnaire (PHQ-9). NAFLD was defined by utilising the US fatty liver index (USFLI), hepatic steatosis index (HSI) and the fatty liver index (FLI) in the absence of other causes of chronic liver disease. The presence and absence of advanced fibrosis in NAFLD were defined by Fibrosis-4 score. Results Of the 10 484 subjects (mean age 47.0 years; 48.8% men), the prevalence of depression and functional impairment due to depression was higher in subjects with NAFLD than in those without. Compared to subjects without depression, those with depression were 1.6-2.2-fold more likely to have NAFLD. In our multivariate analyses, depression_med was associated with increased risk of NAFLD using USFLI (odds ratio [OR] 1.48 95% confidence interval [CI] 1.17-1.87), HSI (OR 1.51 95% CI 1.04-2.19) and FLI (OR 2.01 95% CI 1.65-2.48), respectively. The addition of diabetes, obesity and lipid profile to the model reduced the ORs for depression, but the significance persisted. Depression was not associated with NAFLD-related advanced fibrosis. Conclusions In a nationally representative sample of US adults, depression was independently associated with NAFLD.
C1 [Kim, Donghee; Tighe, Sean P.; Cholankeril, George; Ahmed, Aijaz] Stanford Univ, Sch Med, Div Gastroenterol & Hepatol, 300 Pasteur Dr, Stanford, CA 94304 USA.
   [Yoo, Eric R.] Santa Clara Valley Med Ctr, Dept Med, San Jose, CA 95128 USA.
   [Li, Andrew A.] Stanford Univ, Sch Med, Dept Med, Stanford, CA USA.
   [Harrison, Stephen A.] Univ Oxford, Radcliffe Dept Med, Oxford, England.
C3 Stanford University; Stanford Medicine; Santa Clara Valley Medical
   Center; Stanford University; University of Oxford
RP Kim, D (corresponding author), Stanford Univ, Sch Med, Div Gastroenterol & Hepatol, 300 Pasteur Dr, Stanford, CA 94304 USA.
EM messmd@chol.com
RI Harrison, Stephen/GON-3283-2022; Ahmed, Ahmed/KQU-2025-2024; Kim,
   Donghee/C-4288-2013
OI Li, Andrew/0000-0002-1295-8115; Tighe, Sean/0000-0002-9256-9477; Kim,
   Donghee/0000-0003-1919-6800
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NR 46
TC 79
Z9 81
U1 3
U2 15
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0269-2813
EI 1365-2036
J9 ALIMENT PHARM THER
JI Aliment. Pharmacol. Ther.
PD SEP
PY 2019
VL 50
IS 5
BP 590
EP 598
DI 10.1111/apt.15395
EA JUL 2019
PG 9
WC Gastroenterology & Hepatology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Gastroenterology & Hepatology; Pharmacology & Pharmacy
GA IR5CN
UT WOS:000478554200001
PM 31328300
DA 2025-06-11
ER

PT J
AU Barbagallo, I
   Nicolosi, A
   Calabrese, G
   David, S
   Cimino, S
   Madonia, M
   Cappello, F
AF Barbagallo, Ignazio
   Nicolosi, Anna
   Calabrese, Giorgio
   David, Sabrina
   Cimino, Sebastiano
   Madonia, Massimo
   Cappello, Francesco
TI The Role of the Heme Oxygenase System in the Metabolic Syndrome
SO CURRENT PHARMACEUTICAL DESIGN
LA English
DT Article
DE Metabolic syndrome; heme oxygenase; insulin sensitivity; adiponectin;
   heat shock proteins
ID IMPROVES INSULIN SENSITIVITY; ENDOPLASMIC-RETICULUM STRESS;
   ADIPOSE-TISSUE; GLUCOSE-METABOLISM; OXIDATIVE STRESS; MACROPHAGE
   INFILTRATION; CELL DYSFUNCTION; CARBON-MONOXIDE; UP-REGULATION;
   RESISTANCE
AB Molecular chaperones and the heat shock response play a major role in the maintenance of cellular homeostasis under various pathological conditions. In particular, their role is to regulate protein conformation, protect proteins from misfolding and aggregation, and maintain signalling and organellarnetworks. Among variousheat shock proteins, Hsp32 also known as heme oxygenase-1 (HO-1), has demonstrated an important role in metabolic syndrome. In particular, the HO system seems to play a major role in the complex pathophysiological cascade involved in insulin resistance mechanisms, and adipocyte functions as measured by the release of important adipokynes. The aim of the present review is to point out the role of HO-1 in metabolic syndrome, and how to exploit its beneficial effects as a therapeutic strategy to prevent complicationsof andto improve insulin sensitivity.
C1 [Barbagallo, Ignazio; Nicolosi, Anna] Univ Catania, Dept Drug Sci, I-95125 Catania, Italy.
   [Barbagallo, Ignazio; Cappello, Francesco] Ist Euromediterraneo Sci & Tecnol, Palermo, Italy.
   [Calabrese, Giorgio] Piemonte Orientale Univ, Dept Biol, Alessandria, Italy.
   [David, Sabrina; Cappello, Francesco] Univ Palermo, Dept Expt Biomed & Clin Neurosci, I-90133 Palermo, Italy.
   [Cimino, Sebastiano] Univ Catania, Dept Urol, I-95125 Catania, Italy.
   [Madonia, Massimo] Univ Sassari, Dept Urol, I-07100 Sassari, Italy.
   [Cappello, Francesco] LU de S Univ Human Sci & Technol, Inst Paolo Sotgiu Res Quantitat & Quantum Psychia, Lugano, Switzerland.
C3 University of Catania; University of Eastern Piedmont Amedeo Avogadro;
   University of Palermo; University of Catania; University of Sassari
RP Barbagallo, I (corresponding author), Univ Catania, Dept Drug Sci, Viale Andrea Doria 6, I-95125 Catania, Italy.
EM ignazio.barbagallo@unict.it
RI ; Cappello, Francesco/F-9153-2012
OI Barbagallo, Ignazio/0000-0002-7761-0662; DAVID,
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NR 70
TC 20
Z9 22
U1 0
U2 2
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1381-6128
EI 1873-4286
J9 CURR PHARM DESIGN
JI Curr. Pharm. Design
PY 2014
VL 20
IS 31
BP 4970
EP 4974
PG 5
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA AN7YJ
UT WOS:000340816600005
PM 24320035
DA 2025-06-11
ER

PT J
AU Lawn, S
   Zabeen, S
   Rowlands, N
   Picot, S
AF Lawn, Sharon
   Zabeen, Sara
   Rowlands, Nikki
   Picot, Sharon
TI Hidden care: Revelations of a case-note audit of physical health care in
   a community mental health service
SO INTERNATIONAL JOURNAL OF MENTAL HEALTH NURSING
LA English
DT Article
DE clinical audit; comorbidity; monitoring; physical health; screening
ID CARDIOVASCULAR-DISEASE; TRANSLATING EVIDENCE; METABOLIC SYNDROME;
   ILLNESS; PEOPLE; CONSUMERS; MULTIMORBIDITY; PREVALENCE; USERS
AB People with severe mental illness (SMI) are widely reported to be at an increased risk of morbidity and premature death due to physical health conditions. Mental health nurses are ideally placed to address physical and mental health comorbidity as part of their day-to-day practice. This study involved an audit of hardcopy and electronic clinical case-notes of a random sample of 100 people with SMI case managed by community mental health service in metropolitan South Australia, to determine how well physical health conditions and risk factors, screening, and follow-up are recorded within their service records. Every contact between 1 July 2015 and 30 June 2016 was read. One-way ANOVA, Scheffe's test, and Fisher's exact test determined any significant associations across audit variables, which included gender, age, income, living arrangement, diagnosis, lifestyle factors, recording of physical health measures, and carer status. A focus on physical health care was evident from everyday case-note records; however, because this information was 'buried' within the plethora of entries and not brought to the fore with other key information about the person's psychiatric needs, it remained difficult to gain a full picture of potential gaps in physical health care for this population. Under-reporting, gaps and inconsistencies in the systematic recording of physical health information for this population are likely to undermine the quality of care they receive from mental health services, the ability of mental health service providers to respond in a timely way to their physical healthcare needs, and their communication with other healthcare providers.
C1 [Lawn, Sharon; Zabeen, Sara; Rowlands, Nikki] Flinders Univ S Australia, Coll Med & Publ Hlth, Flinders Human Behav & Hlth Res Unit, Adelaide, SA, Australia.
   [Rowlands, Nikki; Picot, Sharon] Southern Adelaide Local Hlth Network, Southern Mental Hlth, Adelaide, SA, Australia.
C3 Flinders University South Australia
RP Lawn, S (corresponding author), Flinders Univ S Australia, Flinders Human Behav & Hlth Res Unit, Margaret Tobin Ctr, POB 2100, Adelaide, SA 5001, Australia.
EM sharon.lawn@flinders.edu.au
RI Zabeen, Sara/N-8836-2019; Lawn, Sharon/E-1171-2015
OI Lawn, Sharon/0000-0002-5464-8887; Zabeen, Sara/0000-0002-3730-0328
FU Flinders University Faculty Grant
FX This research was partially funded by a Flinders University Faculty
   Grant. We thank Southern Mental Health Directorate and GP Plus Marion
   Mental Health Service, Southern Adelaide Local Health Network for its
   collaboration in undertaking this research. We also thank Dr Melanie
   Harris for her early work on this project.
CR *AIHW, 2017, OV OB
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NR 54
TC 5
Z9 6
U1 1
U2 11
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1445-8330
EI 1447-0349
J9 INT J MENT HEALTH NU
JI Int. J. Ment. Health Nurs.
PD DEC
PY 2018
VL 27
IS 6
BP 1742
EP 1755
DI 10.1111/inm.12479
PG 14
WC Nursing; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Psychiatry
GA HC4OJ
UT WOS:000451782800014
PM 29797643
DA 2025-06-11
ER

PT J
AU Malhotra, N
   Kulhara, P
   Chakrabarti, S
   Grover, S
AF Malhotra, Nidhi
   Kulhara, Parmanand
   Chakrabarti, Subho
   Grover, Sandeep
TI Lifestyle related factors & impact of metabolic syndrome on quality of
   life, level of functioning & self-esteem in patients with bipolar
   disorder & schizophrenia
SO INDIAN JOURNAL OF MEDICAL RESEARCH
LA English
DT Article
DE Bipolar disorder; lifestyle; metabolic syndrome; quality of life;
   schizophrenia
ID RATING-SCALE; WEIGHT; PREVALENCE; OBESITY; QUESTIONNAIRE; VALIDATION;
   VALIDITY; INDIA; RISK
AB Background & objectives: Though studies have reported high prevalence rates of metabolic syndrome among patients with bipolar disorder (BPAD) and schizophrenia, there is lack of data on the impact of the same on the patients' life. This study was aimed to assess the lifestyle related factors associated with metabolic syndrome (MetS) and to study the impact of MetS on functioning and quality of life (QOL) in patients with BPAD and schizophrenia.
   Methods: A total of 102 patients with BPAD and 72 patients with schizophrenia attending the output unit of a tertiary care hospital in north India were evaluated for MetS. These patients were assessed on Health Promoting Lifestyle Profile scale II (HPLP II), World Health Organization QOL -Bref Version (WHOQOL-Bref), Impact of Weight on Quality of Life- Lite version (IWOQOL-Lite), Body weight, Image and Self-esteem Evaluation questionnaire (BWISE), Obesity-related Problem scale (OP scale) and Global Assessment of Functioning (GAF) scale.
   Results: MetS was associated with lower scores on domains of health responsibility and nutrition habit domain on HPLP-II scale in both groups, and additionally on physical activity and stress management domain in BPAD group. On WHOQOL-Bref, MetS was associated with lower scores on the domains of physical and psychological health in both groups. On IWQOL-Lite, scores on personal distress and self esteem domains were higher in those with obesity in both groups and also on physical activity domain in schizophrenia group. Those with MetS had lower level of functioning as measured by GAF in schizophrenia group. Fulfillment of higher number of criteria of MetS correlated with poorer quality of life and higher problems in both groups.
   Interpretation & conclusions: Many modifiable lifestyle factors increase the risk of MetS. MetS was found to be associated with poorer QOL in patients with BPAD and schizophrenia; in addition, obesity led to poor self-esteem and excessive personal distress.
C1 [Malhotra, Nidhi; Kulhara, Parmanand; Chakrabarti, Subho; Grover, Sandeep] Postgrad Inst Med Educ & Res, Dept Psychiat, Chandigarh 160012, India.
C3 Post Graduate Institute of Medical Education & Research (PGIMER),
   Chandigarh
RP Grover, S (corresponding author), Postgrad Inst Med Educ & Res, Dept Psychiat, Chandigarh 160012, India.
EM drsandeepg2002@yahoo.com
OI chakrabarti, subho/0000-0001-6023-2194
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NR 31
TC 41
Z9 47
U1 0
U2 16
PU MEDKNOW PUBLICATIONS & MEDIA PVT LTD
PI MUMBAI
PA B-9, KANARA BUSINESS CENTRE, OFF LINK RD, GHAKTOPAR-E, MUMBAI, 400075,
   INDIA
SN 0971-5916
J9 INDIAN J MED RES
JI Indian J. Med. Res.
PD APR
PY 2016
VL 143
BP 434
EP 442
DI 10.4103/0971-5916.184284
PG 9
WC Immunology; Medicine, General & Internal; Medicine, Research &
   Experimental
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Immunology; General & Internal Medicine; Research & Experimental
   Medicine
GA DQ0WC
UT WOS:000378921500010
PM 27377499
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Chaplin, A
   Carpéné, C
   Mercader, J
AF Chaplin, Alice
   Carpene, Christian
   Mercader, Josep
TI Resveratrol, Metabolic Syndrome, and Gut Microbiota
SO NUTRIENTS
LA English
DT Review
DE resveratrol; gut microbiota; metabolic syndrome
ID FATTY LIVER-DISEASE; CARDIOVASCULAR RISK-FACTORS; INDUCED OXIDATIVE
   STRESS; LONG-TERM CONSUMPTION; ADIPOSE-TISSUE; INSULIN-RESISTANCE;
   TRANS-RESVERATROL; IN-VIVO; INTESTINAL MICROBIOTA; GLUCOSE-METABOLISM
AB Resveratrol is a polyphenol which has been shown to have beneficial effects on metabolic syndrome-related alterations in experimental animals, including glucose and lipid homeostasis improvement and a reduction in fat mass, blood pressure, low-grade inflammation, and oxidative stress. Clinical trials have been carried out to address its potential; however, results are still inconclusive. Even though resveratrol is partly metabolized by gut microbiota, the relevance of this "forgotten organ" had not been widely considered. However, in the past few years, data has emerged suggesting that the therapeutic potential of this compound may be due to its interaction with gut microbiota, reporting changes in bacterial composition associated with beneficial metabolic outcomes. Even though data is still scarce and for the most part observational, it is promising nevertheless, suggesting that resveratrol supplementation could be a useful tool for the treatment of metabolic syndrome and its associated conditions.
C1 [Chaplin, Alice] Case Western Reserve Univ, Sch Med, Cardiovasc Res Inst, Cleveland, OH 44106 USA.
   [Carpene, Christian] INSERM, U1048, Inst Metab & Cardiovasc Dis I2MC, F-31432 Toulouse, France.
   [Carpene, Christian] Univ Paul Sabatier, F-31432 Toulouse, France.
   [Mercader, Josep] Univ Balearic Isl, Dept Fundamental Biol & Hlth Sci, Palma De Mallorca 07122, Spain.
   [Mercader, Josep] Balear Isl Hlth Res Inst IdISBa, Palma De Mallorca 07122, Spain.
C3 University System of Ohio; Case Western Reserve University; Institut
   National de la Sante et de la Recherche Medicale (Inserm); Universite de
   Toulouse; Universite Toulouse III - Paul Sabatier; Universitat de les
   Illes Balears; Institut Investigacio Sanitaria Illes Balears (IdISBa)
RP Chaplin, A (corresponding author), Case Western Reserve Univ, Sch Med, Cardiovasc Res Inst, Cleveland, OH 44106 USA.; Mercader, J (corresponding author), Univ Balearic Isl, Dept Fundamental Biol & Hlth Sci, Palma De Mallorca 07122, Spain.; Mercader, J (corresponding author), Balear Isl Hlth Res Inst IdISBa, Palma De Mallorca 07122, Spain.
EM amc315@case.edu; christian.carpene@inserm.fr; josep.mercader@uib.es
RI Carpéné, Christian/S-3279-2019; Chaplin, Alice/R-5067-2019; Mercader,
   J/I-1867-2017
OI Mercader Barcelo, Josep/0000-0002-5293-2809; Chaplin,
   Alice/0000-0003-0685-4237
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NR 220
TC 187
Z9 203
U1 5
U2 87
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD NOV
PY 2018
VL 10
IS 11
AR 1651
DI 10.3390/nu10111651
PG 29
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA HC1GH
UT WOS:000451547700089
PM 30400297
OA Green Published, gold, Green Submitted
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Ren, J
   Anversa, P
AF Ren, Jun
   Anversa, Piero
TI The insulin-like growth factor I system: Physiological and
   pathophysiological implication in cardiovascular diseases associated
   with metabolic syndrome
SO BIOCHEMICAL PHARMACOLOGY
LA English
DT Article
DE IGF-1; Metabolic syndrome; Obesity; Heart diseases
ID CARDIAC CONTRACTILE DYSFUNCTION; BINDING PROTEIN-1 LEVELS; IGF-I;
   OXIDATIVE STRESS; LIFE-SPAN; DIABETIC CARDIOMYOPATHY; VENTRICULAR
   MYOCYTES; CIXUTUMUMAB IMC-A12; GLUCOSE-INTOLERANCE; PROGENITOR CELLS
AB Metabolic syndrome is a cluster of risk factors including obesity, dyslipidemia, hypertension, and insulin resistance. A number of theories have been speculated for the pathogenesis of metabolic syndrome including impaired glucose and lipid metabolism, lipotoxicity, oxidative stress, interrupted neurohormonal regulation and compromised intracellular Ca2+ handling. Recent evidence has revealed that adults with severe growth hormone (GH) and insulin-like growth factor I (IGF-1) deficiency such as Laron syndrome display increased risk of stroke and cardiovascular diseases. IGF-1 signaling may regulate contractility, metabolism, hypertrophy, apoptosis, autophagy, stem cell regeneration and senescence in the heart to maintain cardiac homeostasis. An inverse relationship between plasma IGF-1 levels and prevalence of metabolic syndrome as well as associated cardiovascular complications has been identified, suggesting the clinical promises of IGF-1 analogues or IGF-1 receptor activation in the management of metabolic and cardiovascular diseases. However, the underlying pathophysiological mechanisms between IGF-1 and metabolic syndrome are still poorly understood. This mini-review will discuss the role of IGF-1 signaling cascade in the prevalence of metabolic syndrome in particular the susceptibility to overnutrition and sedentary life style-induced obesity, dyslipidemia, insulin resistance and other features of metabolic syndrome. Special attention will be dedicated in IGF-1-associated changes in cardiac responses in various metabolic syndrome components such as insulin resistance, obesity, hypertension and dyslipidemia. The potential risk of IGF-1 and IGF-1R stimulation such as tumorigenesis is discussed. Therapeutic promises of IGF-1 and IGF-1 analogues including mecasermin, mecasermin rinfabate and PEGylated IGF-1 will be discussed. (C) 2014 Elsevier Inc. All rights reserved.
C1 [Ren, Jun] Fudan Univ, Zhongshan Hosp, Shanghai Inst Cardiovasc Dis, Shanghai 200032, Peoples R China.
   [Ren, Jun] Univ Wyoming, Coll Hlth Sci, Ctr Cardiovasc Res & Alternat Med, Laramie, WY 82071 USA.
   [Anversa, Piero] Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Anesthesia, Boston, MA 02115 USA.
   [Anversa, Piero] Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Med, Boston, MA 02115 USA.
   [Anversa, Piero] Harvard Univ, Brigham & Womens Hosp, Sch Med, Div Cardiovasc, Boston, MA 02115 USA.
C3 Fudan University; University of Wyoming; Harvard University; Harvard
   University Medical Affiliates; Brigham & Women's Hospital; Harvard
   Medical School; Harvard University; Harvard University Medical
   Affiliates; Brigham & Women's Hospital; Harvard Medical School; Harvard
   University; Harvard University Medical Affiliates; Brigham & Women's
   Hospital; Harvard Medical School
RP Ren, J (corresponding author), Fudan Univ, Zhongshan Hosp, Shanghai Inst Cardiovasc Dis, Shanghai 200032, Peoples R China.
EM ren.jun@zs-hospital.sh.cn
RI Ren, Jun/ACG-5366-2022
OI Ren, Jun/0000-0002-0275-0783
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NR 131
TC 77
Z9 86
U1 0
U2 41
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0006-2952
EI 1873-2968
J9 BIOCHEM PHARMACOL
JI Biochem. Pharmacol.
PD FEB 15
PY 2015
VL 93
IS 4
BP 409
EP 417
DI 10.1016/j.bcp.2014.12.006
PG 9
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA CB1ZN
UT WOS:000349426600001
PM 25541285
DA 2025-06-11
ER

PT J
AU Gaman, MA
   Srichawla, BS
   Chen, YF
   Roy, P
   Dhali, A
   Nahian, A
   Manan, MR
   Kipkorir, V
   Suteja, RC
   Kutikuppala, LVS
   Gaman, AM
   Diaconu, CC
AF Gaman, Mihnea-Alexandru
   Srichawla, Bahadar Singh
   Chen, Yong-Feng
   Roy, Poulami
   Dhali, Arkadeep
   Nahian, Ahmed
   Manan, Muhammad Romail
   Kipkorir, Vincent
   Suteja, Richard Christian
   Simhachalam Kutikuppala, Lakshmi Venkata
   Gaman, Amelia Maria
   Diaconu, Camelia Cristina
TI Overview of dyslipidemia and metabolic syndrome in myeloproliferative
   neoplasms
SO WORLD JOURNAL OF CLINICAL ONCOLOGY
LA English
DT Review
DE Polycythemia vera; Essential thrombocythemia; Myelofibrosis;
   Cardiovascular disease; Hypercholesterolemia; Hypertriglyceridemia;
   Obesity; Diabetes; Inflammation; Oxidative stress
ID JAK-STAT PATHWAY; OXIDATIVE STRESS; ESSENTIAL THROMBOCYTHEMIA; CHRONIC
   INFLAMMATION; POLYCYTHEMIA-VERA; ACCELERATED ATHEROSCLEROSIS; CLONAL
   HEMATOPOIESIS; CANCER; MYELOFIBROSIS; EPIDEMIOLOGY
AB Myeloproliferative neoplasms (MPNs) occur due to the abnormal proliferation of one or more terminal myeloid cell lines in peripheral blood. Subjects suffering from MPNs display a high burden of cardiovascular risk factors, and thrombotic events are often the cause of death in this population of patients. Herein, we provide a brief overview of dyslipidemia and metabolic syndrome and their epidemiology in MPNs and examine the common molecular mechanisms between dyslipidemia, metabolic syndrome, and MPNs, with a special focus on cardiovascular risk, atherosclerosis, and thrombotic events. Furthermore, we investigate the impact of dyslipidemia and metabolic syndrome on the occurrence and survival of thrombosis in MPN patients, as well as the management of dyslipidemia in MPNs, and the impact of MPN treatment on serum lipid concentrations, particularly as side/adverse effects reported in the context of clinical trials.
C1 [Gaman, Mihnea-Alexandru] Carol Davila Univ Med & Pharm, Fac Med, Bucharest 050474, Romania.
   [Gaman, Mihnea-Alexandru] Fundeni Clin Inst, Ctr Hematol & Bone Marrow Transplantat, Dept Hematol, Bucharest 022328, Romania.
   [Gaman, Mihnea-Alexandru] Romanian Acad, Stefan S Nicolau Inst Virol, Dept Cellular & Mol Pathol, Bucharest 030304, Romania.
   [Srichawla, Bahadar Singh] Univ Massachusetts, Chan Med Sch, Dept Neurol, Worcester, MA 01655 USA.
   [Chen, Yong-Feng] Taizhou Univ, Dept Basic Med Sci, Sch Med, Taizhou 318000, Zhejiang, Peoples R China.
   [Roy, Poulami] North Bengal Med Coll & Hosp, Dept Med, Darjeeling 734012, W Bengal, India.
   [Dhali, Arkadeep] Sheffield Teaching Hosp NHS Fdn Trust, Acad Dept Gastroenterol, Sheffield S5 7AU, England.
   [Nahian, Ahmed] Lecom Seton Hill, Greensburg, PA 15601 USA.
   [Manan, Muhammad Romail] Serv Hosp, Fac Med, Lahore 54000, Pakistan.
   [Kipkorir, Vincent] Univ Nairobi, Dept Human Anat & Physiol, Nairobi 00100, Kenya.
   [Suteja, Richard Christian] Udayana Univ, Fac Med, Denpasar 80361, Bali, Indonesia.
   [Simhachalam Kutikuppala, Lakshmi Venkata] Dr NTR Univ Hlth Sci, Dept Gen Surg, Vijayawada 520008, Andhra Pradesh, India.
   [Gaman, Amelia Maria] Univ Med & Pharm Craiova, Dept Pathophysiol, Petru Rares No 2, Craiova 200349, Romania.
   [Gaman, Amelia Maria] Filantropia City Hosp, Clin Hematol, Craiova 200143, Romania.
   [Diaconu, Camelia Cristina] Carol Davila Univ Med & Pharm, Fac Med, Dept Internal Med, Bucharest 050474, Romania.
   [Diaconu, Camelia Cristina] Clin Emergency Hosp Bucharest, Internal Med Clin, Bucharest 105402, Romania.
C3 Carol Davila University of Medicine & Pharmacy; Institutul Clinic
   Fundeni; Romanian Academy; Stefan S. Nicolau Institute of Virology;
   University of Massachusetts System; UMass Chan Medical School;
   University of Massachusetts Worcester; Taizhou University; University of
   Sheffield; University of Nairobi; Universitas Udayana; University of
   Medicine & Pharmacy of Craiova; Carol Davila University of Medicine &
   Pharmacy
RP Gaman, AM (corresponding author), Univ Med & Pharm Craiova, Dept Pathophysiol, Petru Rares No 2, Craiova 200349, Romania.
EM gamanamelia@yahoo.com
RI Suteja, Richard/AFN-4393-2022; Srichawla, Bahadar/ABC-2084-2020;
   Kipkorir, Dr. Vincent/AAD-6199-2022; Kutikuppala, L V
   Simhachalam/AAL-4124-2021; Roy, Poulami/IVU-9280-2023; Dhali,
   Arkadeep/AAW-9655-2021; Diaconu, Camelia/A-2144-2019; Manan, Muhammad
   Romail/AAX-8364-2021; Gaman, Mihnea-Alexandru/O-4258-2016; Gaman,
   Amelia/E-8365-2017
OI Gaman, Mihnea-Alexandru/0000-0001-7133-8875; Gaman,
   Amelia/0000-0001-6974-2772
FU Competitiveness Operational Programme [P_37_798, 149/26.10.2016, 106774]
FX Supported by the Grant Funded by Competitiveness Operational Programme
   A1.1.4. ID: P_37_798 MYELOAL-EDIAPROT (to G & abreve;man MA), No.
   149/26.10.2016 (MySMIS2014+: 106774).
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NR 100
TC 0
Z9 0
U1 1
U2 2
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 7041 Koll Center Parkway, Suite 160, PLEASANTON, CA, UNITED STATES
SN 2218-4333
J9 WORLD J CLIN ONCOL
JI World J. Clin. Oncol.
PD JUN 24
PY 2024
VL 15
IS 6
DI 10.5306/wjco.v15.i6.717
PG 14
WC Oncology
WE Emerging Sources Citation Index (ESCI)
SC Oncology
GA XY0L2
UT WOS:001265121200011
PM 38946827
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Coyne, T
   Ibiebele, TI
   Baade, PD
   McClintock, CS
   Shaw, JE
AF Coyne, Terry
   Ibiebele, Torukiri I.
   Baade, Peter D.
   McClintock, Christine S.
   Shaw, Jonathan E.
TI Metabolic syndrome and serum carotenoids: findings of a cross-sectional
   study in Queensland, Australia
SO BRITISH JOURNAL OF NUTRITION
LA English
DT Article
DE Carotenoids; Metabolic syndrome; Cross-sectional studies
ID TYPE-2 DIABETES-MELLITUS; ARTERY RISK DEVELOPMENT; 3RD NATIONAL-HEALTH;
   OXIDATIVE STRESS; BETA-CAROTENE; YOUNG-ADULTS; ANTIOXIDANT
   CONCENTRATIONS; CARDIOVASCULAR-DISEASE; LIFE-STYLE; PLASMA
AB Several components of the metabolic syndrome, particularly diabetes and CVD, are known to be oxidative stress-related conditions and there is research to suggest that antioxidant nutrients may play a protective role in these conditions. Carotenoids are compounds derived primarily front plants and several have been shown to be potent antioxidant nutrients. The aim of the present study was to examine the associations between metabolic syndrome status and major serum carotenoids in adult Australians. Data on the presence of the metabolic syndrome, based on International Diabetes Federation 2005 criteria, were collected from 1523 adults aged 25 years and over in six randomly selected urban centres in Queensland, Australia, using a cross-sectional study design. Weight, height, BMI, waist circumference, blood pressure, fasting and 2 h blood glucose and lipids were determined, as well as five serum carotenoids. Mean serum alpha-, beta-carotenes and the sum of the five carotenoid concentrations were significantly lower (P<0.05) in persons with the metabolic syndrome (after adjusting for age, sex, education, BMI status, alcohol intake, smoking, physical activity status and vitamin/mineral use) than persons without the syndrome. alpha-, beta- and total carotenoids also decreased significantly (P<0.05) with increased number of components of the metabolic syndrome, after adjusting for these confounders. These differences were significant among former smokers and non-smokers, but not in present smokers. Low concentrations of serum alpha-, beta-carotenes and the sum of five carotenoids appear to be associated with metabolic syndrome status. Additional research, particularly longitudinal studies, may help to determine whether these associations are causally related to the metabolic syndrome, or are a result of the pathologies of the syndrome.
C1 [Coyne, Terry] Univ Queensland, Sch Populat Hlth, Brisbane, Qld, Australia.
   [Ibiebele, Torukiri I.] Queensland Inst Med Res, Brisbane, Qld 4006, Australia.
   [Baade, Peter D.] Canc Council Queensland, Viertel Ctr Res Canc Control, Brisbane, Qld, Australia.
   [Baade, Peter D.] Queensland Univ Technol, Sch Publ Hlth, Brisbane, Qld 4001, Australia.
   [McClintock, Christine S.] Univ Queensland, Ctr Mil & Vet Hlth, Brisbane, Qld, Australia.
   [Shaw, Jonathan E.] Baker IDI Heart & Diabet Inst, Melbourne, Vic, Australia.
C3 University of Queensland; QIMR Berghofer Medical Research Institute;
   Cancer Council Queensland; Queensland University of Technology (QUT);
   University of Queensland; Baker Heart and Diabetes Institute
RP Coyne, T (corresponding author), Univ Queensland, Sch Populat Hlth, Brisbane, Qld, Australia.
EM terrycoyne@comcast.net
RI McClintock, Christine/B-8542-2011; Baade, Peter/C-4113-2009; Shaw,
   Jonathan/E-7388-2010
OI Baade, Peter/0000-0001-8576-8868; Ibiebele, Torukiri/0009-0001-5025-0169
FU Australian Commonwealth Department of Health and Ageing, Queensland
   Health, Diabetes Australia; Australian Kidney Foundation and
   pharmaceutical companies
FX The present study was Supported by the Australian Commonwealth
   Department of Health and Ageing, Queensland Health, Diabetes Australia,
   the Australian Kidney Foundation and pharmaceutical companies: Abbott
   Australasia Pty Ltd, Alphapharm Pty Ltd, Aventis Pharmaceutical,
   AstraZeneca, Aventis Pharmaceutical, Bristol-Myers Squibb
   Pharmaceuticals, Eli Lilly (Aust) Pty Ltd, GlaxoSmithKline,
   Janssen-Cilag (Aust) Pty Ltd, Merck Lipha s.a., Merck Sharp and Dohme
   (Aust), Novartis Pharmaceutical (Aust) Ply Ltd., Novo Nordisk
   Pharmaceutical Ply Ltd, Pharmacia and Upjohn Ply Ltd, Pfizer Pty Ltd,
   Roche Diagnostics, Sanofii Synthelabo (Aust) Pty Ltd, Servier
   Laboratories (Aust) Pty Ltd. All authors approved the final version of
   the present paper. T. C. was responsible for the concept and conduct of
   the study and preparing the manuscript. T. I. I. performed the
   statistical analyses and writing the results section. P. D. B. provided
   technical assistance on the data analyses and on writing and
   interpretation. C. S. Me. C and J. E. S. provided details regarding the
   study methods and interpretation of findings. None of the authors had
   any personal or financial interest in the companies that supported the
   study. No conflict of interest exists.
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NR 42
TC 50
Z9 56
U1 0
U2 13
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1145
EI 1475-2662
J9 BRIT J NUTR
JI Br. J. Nutr.
PD DEC 14
PY 2009
VL 102
IS 11
BP 1668
EP 1677
DI 10.1017/S000711450999081X
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 532QM
UT WOS:000272764500017
PM 19631019
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Martin, H
   Beard, S
   Clissold, N
   Andraos, K
   Currey, L
AF Martin, Heather
   Beard, Samuel
   Clissold, Nathan
   Andraos, Kameel
   Currey, Luke
TI Combined aerobic and resistance exercise interventions for individuals
   with schizophrenia: A systematic review
SO MENTAL HEALTH AND PHYSICAL ACTIVITY
LA English
DT Review
ID MAJOR DEPRESSIVE DISORDER; PHYSICAL-ACTIVITY; CARDIORESPIRATORY FITNESS;
   PSYCHOTIC DISORDERS; BIPOLAR DISORDER; CLINICAL-TRIALS; PEOPLE; HEALTH;
   METAANALYSIS; MORTALITY
AB Introduction: Individuals with schizophrenia are more susceptible to cardiometabolic health risks due to increased sedentary behaviour. Exercise has been shown to modify cardiometabolic risk factors and mental health. We conducted a systematic review to identify effects of combined aerobic and resistance training on individuals with schizophrenia; and to aid the development of specific exercise guidelines.
   Methods: A systematic database search was conducted from inception until 09/16 for articles using combined exercise interventions measuring mental health variables, cardiovascular fitness or strength in individuals with schizophrenia. Of 2454 references, seven randomised control trials were eligible. Data extraction included outcome measures, study design, objectives, intervention, control, participants demographic, dropout, follow-up, study quality, and risk of bias.
   Results: Seven studies were eligible, involving 389 individuals with schizophrenia (mean age 38.7; 62% male) where 193 were assigned to intervention and 182 to control. Combined exercise was found to improve strength, symptoms of schizophrenia and overall mental health. Though improvements in cardiovascular fitness were not statistically significant they were still clinically meaningful. Program variables were poorly reported, however, interventions averaged approximately 95 min of aerobic exercise and strength training on 2 days per week at 50-85%1RM intensity. Research was scarce and overall, was of low study quality, with a high risk of bias.
   Conclusion: Combined exercise for individuals with schizophrenia is effective at improving strength and mental health variables. Current guidelines are adapted and non-specific for this population therefore development of specific guidelines should be a focus of future research. (C) 2017 Elsevier Ltd. All rights reserved.
C1 [Martin, Heather; Beard, Samuel; Clissold, Nathan; Andraos, Kameel; Currey, Luke] Univ Sydney, Fac Hlth Sci, Lidcombe, NSW 2141, Australia.
C3 University of Sydney
RP Martin, H (corresponding author), 75 East St, Lidcombe, NSW 2141, Australia.
EM hmar4834@uni.sydney.edu.au; sbea4045@uni.sydney.edu.au;
   ncli6266@uni.sydney.edu.au; kand9204@uni.sydney.edu.au;
   lcur4274@uni.sydney.edu.au
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   Vancampfort D, 2016, DISABIL REHABIL, V38, P2235, DOI 10.3109/09638288.2015.1116622
   Vancampfort D, 2016, WORLD PSYCHIATRY, V15, P166, DOI 10.1002/wps.20309
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NR 38
TC 19
Z9 19
U1 3
U2 20
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1755-2966
EI 1878-0199
J9 MENT HEALTH PHYS ACT
JI Ment. Health Phys. Act.
PD MAR
PY 2017
VL 12
BP 147
EP 155
DI 10.1016/j.mhpa.2017.04.003
PG 9
WC Psychology, Clinical; Psychiatry
WE Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA EX8QL
UT WOS:000403515200019
DA 2025-06-11
ER

PT J
AU Haghighatdoost, F
   Kelishadi, R
   Qorbani, M
   Heshmat, R
   Motlagh, ME
   Ardalan, G
   Azadbakht, L
AF Haghighatdoost, Fahimeh
   Kelishadi, Roya
   Qorbani, Mostafa
   Heshmat, Ramin
   Motlagh, Mohammad Esmaeil
   Ardalan, Gelayol
   Azadbakht, Leila
TI Family Dinner Frequency is Inversely Related to Mental Disorders and
   Obesity in Adolescents: the CASPIAN-III Study
SO ARCHIVES OF IRANIAN MEDICINE
LA English
DT Article
DE Adolescents; anxiety; dinner; mental disorders Iran; obesity
ID CHILDHOOD OVERWEIGHT; METABOLIC SYNDROME; IRANIAN CHILDREN;
   DIETARY-INTAKE; BODY-WEIGHT; MEAL; PREVALENCE; QUALITY; HEALTH; INDEX
AB Purpose: Family dinner is a proxy of family connectedness that may affect mental health. The present study aimed to examine the associations of frequency of family dinner with mental disorders and obesity in a nationally-representative sample of Iranian adolescents.
   Methods: A total of 5528 Iranians adolescents aged 10-18 years were enrolled in 2009 - 2010 in the third survey of a national surveillance program, entitled Childhood and Adolescence Surveillance and Prevention of Adult Non-communicable disease (CASPIAN-III) study. The frequency of family dinner meal was assessed. Mental health assessments were done as part of the World Health Organization-Global School-based Student Health Survey. The odds of having mental disorders and obesity were assessed by logistic regression.
   Results: No significant difference was found in dietary intake between family dinner consumers (5 times (night)/wk) and skippers (<5 times/wk); however, they were more likely to consume breakfast and had higher meal frequency. After controlling for some confounders, dinner consumers had lower odds for all types of mental disorders (OR = 0.55; 95% CI = 0.47-0.64), anxiety (OR = 0.47; 95% CI = 0.4-0.54), insomnia (OR = 0.6; 95% CI = 0.53-0.7), and confusion (OR = 0.7; 95% CI = 0.6-0.86), as well as the body mass index-z score (OR = 0.78: 95% CI = 0.73-0.84).
   Conclusion: The current study showed an inverse relationship between the frequency of family dinner consuming and mental disorders and obesity in a nationally-representative sample of Iranian adolescents. Such simple recommendations for consuming family dinner for families may be feasible, sustainable, and effective for health promotion and disease prevention.
C1 [Haghighatdoost, Fahimeh; Azadbakht, Leila] Isfahan Univ Med Sci, Food Secur Res Ctr, Esfahan, Iran.
   [Haghighatdoost, Fahimeh; Azadbakht, Leila] Isfahan Univ Med Sci, Sch Nutr & Food Sci, Dept Community Nutr, Esfahan, Iran.
   [Kelishadi, Roya; Ardalan, Gelayol] Isfahan Univ Med Sci, Res Inst Primordial Prevent Noncommunicable Dis, Dept Pediat, Child Growth & Dev Res Ctr, Esfahan, Iran.
   [Qorbani, Mostafa] Alborz Univ Med Sci, Dept Community Med, Karaj, Iran.
   [Qorbani, Mostafa; Heshmat, Ramin] Univ Tehran Med Sci, Dept Epidemiol, Chron Dis Res Ctr, Endocrinol & Metab Populat Sci Inst, Tehran, Iran.
   [Motlagh, Mohammad Esmaeil] Ahvaz Jundishapur Univ Med Sci, Dept Pediat, Fac Med, Ahvaz, Iran.
   [Azadbakht, Leila] Univ Tehran Med Sci, Diabet Res Ctr, Endocrinol & Metab Clin Sci Inst, Tehran, Iran.
   [Azadbakht, Leila] Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Community Nutr, Tehran, Iran.
C3 Isfahan University of Medical Sciences; Isfahan University of Medical
   Sciences; Isfahan University of Medical Sciences; Alborz University of
   Medical Sciences; Tehran University of Medical Sciences; Ahvaz
   Jundishapur University of Medical Sciences (AJUMS); Tehran University of
   Medical Sciences; Tehran University of Medical Sciences
RP Kelishadi, R (corresponding author), Isfahan Univ Med Sci, Res Inst Primordial Prevent Noncommunicable Dis, Dept Pediat, Child Growth & Dev Res Ctr, Esfahan, Iran.
EM kelishadi@med.mui.ac.ir; l-azadbakht@sina.tums.ac.ir
RI Heshmat, Ramin/S-7435-2017; motlagh, Mohammad/AAC-2653-2019; Qorbani,
   Mostafa/M-8171-2017; Kelishadi, Roya/E-6154-2012; Azadbakht,
   Leila/N-2801-2018
OI Kelishadi, Roya/0000-0001-7455-1495; Azadbakht,
   Leila/0000-0002-5955-6818; motlagh, mohammad esmaiel/0000-0002-2971-8660
CR Azadbakht L, 2013, NUTRITION, V29, P420, DOI 10.1016/j.nut.2012.07.008
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NR 32
TC 10
Z9 10
U1 0
U2 9
PU ACAD MEDICAL SCIENCES I R IRAN
PI TEHRAN
PA PO BOX 19395-5655, TEHRAN, 00000, IRAN
SN 1029-2977
EI 1735-3947
J9 ARCH IRAN MED
JI Arch. Iran. Med.
PD APR
PY 2017
VL 20
IS 4
BP 218
EP 223
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA EW4SL
UT WOS:000402491100004
PM 28412825
DA 2025-06-11
ER

PT J
AU Lam, JCM
   Ip, MSM
AF Lam, Jamie C. M.
   Ip, Mary S. M.
TI An update on obstructive sleep apnea and the metabolic syndrome
SO CURRENT OPINION IN PULMONARY MEDICINE
LA English
DT Article
DE metabolic syndrome; obstructive sleep apnea
ID POSITIVE AIRWAY PRESSURE; CHRONIC INTERMITTENT HYPOXIA;
   INSULIN-RESISTANCE; BLOOD-PRESSURE; RISK-FACTORS; OXIDATIVE STRESS;
   CONTROLLED TRIAL; HEART HEALTH; CARDIOVASCULAR-DISEASE;
   GLUCOSE-INTOLERANCE
AB Purpose of review Patients with obstructive sleep apnea are often overweight or obese, and they frequently exhibit metabolic aberrations, collectively known as the metabolic syndrome, an established cardiovascular risk factor. We review recent data on the relationship between obstructive sleep apnea and metabolic syndrome or its components, including abdominal obesity, insulin resistance, hypertension, and dyslipidemia. Recent findings There is accumulating evidence for an independent association between obstructive sleep apnea and metabolic syndrome or its components. Recent epidemiologic and clinical data suggest a causal role of severe obstructive sleep apnea in development of hypertension, but findings for insulin resistance and dyslipidemia are controversial. Visceral obesity remains a confounding issue in analyses. Animal models and translational studies indicate that obstructive sleep apnea may promote metabolic dysfunction through cycles of intermittent hypoxia; proposed underlying pathophysiologic mechanisms include oxidative stress, sympathetic activation, and inflammation. Summary There is suggestive evidence, but independent associations between obstructive sleep apnea and metabolic syndrome or its components are not fully established because of the confounding effect of obesity. Large randomized interventional trials are needed to identify any cause-effect relationship. Long-term follow-up studies would help to clarify the role of treatment of sleep apnea in reducing cardio-metabolic morbidity.
C1 Univ Hong Kong, Queen Mary Hosp, Univ Dept Med, Pokfulam, Hong Kong, Peoples R China.
C3 University of Hong Kong
RP Ip, MSM (corresponding author), Univ Hong Kong, Queen Mary Hosp, Univ Dept Med, Pokfulam Rd, Pokfulam, Hong Kong, Peoples R China.
EM msmip@hkucc.hku.hk
RI Ip, Mary Sau Man/C-4284-2009
OI Ip, Mary Sau Man/0000-0002-8692-6933
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NR 71
TC 50
Z9 58
U1 0
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1070-5287
EI 1531-6971
J9 CURR OPIN PULM MED
JI Curr. Opin. Pulm. Med.
PD NOV
PY 2007
VL 13
IS 6
BP 484
EP 489
DI 10.1097/MCP.0b013e3282efae9c
PG 6
WC Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Respiratory System
GA 223IL
UT WOS:000250363400004
PM 17901753
DA 2025-06-11
ER

PT J
AU Baker, DG
   Nievergelt, CM
   O'Connor, DT
AF Baker, Dewleen G.
   Nievergelt, Caroline M.
   O'Connor, Daniel T.
TI Biomarkers of PTSD: Neuropeptides and immune signaling
SO NEUROPHARMACOLOGY
LA English
DT Review
DE Posttraumatic stress disorder (PTSD); Depression; Stress; Immune;
   Cytokine; HPA axis
ID POSTTRAUMATIC-STRESS-DISORDER; C-REACTIVE PROTEIN; NF-KAPPA-B;
   METABOTROPIC GLUTAMATE-RECEPTOR; PITUITARY-ADRENAL AXIS;
   CORONARY-HEART-DISEASE; CEREBROSPINAL-FLUID; GLUCOCORTICOID-RECEPTOR;
   METABOLIC SYNDROME; INTERLEUKIN (IL)-6
AB The biological underpinnings for participation of the immune system in the pathogenesis of Posttraumatic Stress Disorder (PTSD) include evidence for cross-talk between the stress and immune systems, as well as more recently discovered roles for immune system mediators in core behavioral functions such as adult neurogenesis, as well as in processes that underlay synaptic plasticity, such as learning and memory. This article reviews the expanding body of literature on immune system mediators in the periphery and the central nervous system (CNS) in chronic PTSD along with the evidence for increased peripheral inflammation, and excess morbidity and mortality. CNS inflammation has been implicated in the pathogenesis of depression. This literature is briefly reviewed, along with evidence for a possible role for CNS inflammation in PTSD symptoms, especially in individuals who have PTSD with co-morbid depression. Whether the immune system is involved in risk and resilience, or evolution of PTSD symptoms following a trauma event remains to be determined, although hypotheses have been advanced. This paper reviews the current evidence including the novel hypothesis that cellular immunity is implicated in PTSD risk and resilience. Potential research implications and directions are discussed. This article is part of a Special Issue entitled 'Post-Traumatic Stress Disorder'. Published by Elsevier Ltd.
C1 [Baker, Dewleen G.] VA San Diego, Vet Affairs Ctr Excellence Stress & Mental Hlth, San Diego, CA USA.
   [Baker, Dewleen G.; Nievergelt, Caroline M.] Univ Calif San Diego, Dept Psychiat, San Diego, CA 92103 USA.
   [O'Connor, Daniel T.] Univ Calif San Diego, Dept Med, San Diego, CA 92103 USA.
C3 US Department of Veterans Affairs; Veterans Health Administration (VHA);
   VA San Diego Healthcare System; University of California System;
   University of California San Diego; University of California System;
   University of California San Diego
RP Baker, DG (corresponding author), Univ Calif San Diego, Dept Psychiat, 9500 Gilman Dr,0603V, La Jolla, CA 92093 USA.
EM dgbaker@ucsd.edu
RI Baker, Dewleen/O-4957-2019
OI Nievergelt, Caroline/0000-0001-5766-8923
FU VA (HSRD); DOD (BUMED, CDMRP) Research; VA Center of Excellence for
   Stress and Mental Health; NIMH [1 U01 MH092758-01]; NIA [1 R01
   AG030474-01A2];  [HL58120 MD000220 (EXPORT/CRCHD)];  [RR031980 (CTSA)]
FX Drs. Baker and Nievergelt are supported in part by VA (HSR&D), DOD
   (BUMED, CDMRP) Research, and by the VA Center of Excellence for Stress
   and Mental Health. Dr. Nievergelt is also supported by grants from NIMH
   (1 U01 MH092758-01) and NIA (1 R01 AG030474-01A2) and Dr. O'Connor is
   supported by HL58120 MD000220 (EXPORT/CRCHD) andRR031980 (CTSA).
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NR 221
TC 137
Z9 152
U1 0
U2 53
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0028-3908
EI 1873-7064
J9 NEUROPHARMACOLOGY
JI Neuropharmacology
PD FEB
PY 2012
VL 62
IS 2
BP 663
EP 673
DI 10.1016/j.neuropharm.2011.02.027
PG 11
WC Neurosciences; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pharmacology & Pharmacy
GA 909FZ
UT WOS:000301549300014
PM 21392516
DA 2025-06-11
ER

PT J
AU Henry, NJM
   Smith, TW
   Butner, J
   Berg, CA
   Sewell, KK
   Uchino, BN
AF Henry, Nancy J. M.
   Smith, Timothy W.
   Butner, Jonathan
   Berg, Cynthia A.
   Sewell, Kelsey K.
   Uchino, Bert N.
TI Marital quality, depressive symptoms, and the metabolic syndrome: a
   couples structural model
SO JOURNAL OF BEHAVIORAL MEDICINE
LA English
DT Article
DE Metabolic syndrome; Marital quality; Depression
ID CORONARY-HEART-DISEASE; CARDIOVASCULAR REACTIVITY; CLOSE RELATIONSHIPS;
   RISK-FACTORS; SATISFACTION; ASSOCIATION; PERSONALITY; WOMEN; SCALE;
   METAANALYSIS
AB The indirect association of marital quality with metabolic syndrome (MetS) through depressive symptoms was examined in 301 middle-aged and older couples. MetS components (i.e., waist circumference, blood pressure, blood draws to assess triglycerides, HDL cholesterol, and fasting glucose) were assessed following a 12-h fast, and were treated as a continuous latent variable for analyses. In structural equation modeling of this indirect effect, overall model fit was good, and husbands' and wives' marital quality was associated with MetS only through depressive symptoms. Joint tests of the parameters indicated that gender did not moderate this association. The best fitting, most parsimonious model, after nested model comparisons, was one in which husbands' and wives' indirect paths were equated. Overall, marital quality was related to MetS through its relationship to depressive symptoms for men and women. Associations of marital quality and depression with MetS may overlap, and couple-based approaches to psychosocial risk factors for cardiovascular disease may be useful in future research.
C1 [Henry, Nancy J. M.; Smith, Timothy W.; Butner, Jonathan; Berg, Cynthia A.; Sewell, Kelsey K.; Uchino, Bert N.] Univ Utah, Div Phys Med & Rehabil, Univ Hlth Care, Sch Med, Salt Lake City, UT 84112 USA.
   [Smith, Timothy W.; Butner, Jonathan; Berg, Cynthia A.; Sewell, Kelsey K.; Uchino, Bert N.] Univ Utah, Dept Psychol, Salt Lake City, UT 84112 USA.
C3 Utah System of Higher Education; University of Utah; Utah System of
   Higher Education; University of Utah
RP Henry, NJM (corresponding author), Univ Utah, Div Phys Med & Rehabil, Univ Hlth Care, Sch Med, 30 North 1900 East, Salt Lake City, UT 84112 USA.
EM nancy.henry@hsc.utah.edu; timothy.smith@psych.utah.edu;
   jonathan.butner@psych.utah.edu; cynthia.berg@psych.utah.edu;
   kelsey.sewell@psych.utah.edu; bert.uchino@psych.utah.edu
RI Butner, Jonathan/LPQ-3807-2024
OI Butner, Jonathan/0000-0002-8747-5708
FU NIH [AG018903]
FX Supported by NIH Grant No. AG018903 awarded to Timothy W. Smith.
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NR 60
TC 10
Z9 13
U1 1
U2 14
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0160-7715
EI 1573-3521
J9 J BEHAV MED
JI J. Behav. Med.
PD JUN
PY 2015
VL 38
IS 3
BP 497
EP 506
DI 10.1007/s10865-015-9619-4
PG 10
WC Psychology, Clinical
WE Social Science Citation Index (SSCI)
SC Psychology
GA CH5PN
UT WOS:000354087900009
PM 25677374
DA 2025-06-11
ER

PT J
AU Trompeter, SE
   Bettencourt, R
   Barrett-Connor, E
AF Trompeter, Susan E.
   Bettencourt, Ricki
   Barrett-Connor, Elizabeth
TI Metabolic Syndrome and Sexual Function in Postmenopausal Women
SO AMERICAN JOURNAL OF MEDICINE
LA English
DT Article
DE FSFI; Female Sexual Function Index; Metabolic syndrome; Sexual
   dysfunction
ID FUNCTION INDEX FSFI; DYSFUNCTION; HYPERTENSION; ASSOCIATION; PREVALENCE;
   VALIDATION; DEPRESSION; DISEASE; RISK; MEN
AB BACKGROUND: Limited literature suggests that sexual dysfunction in women covaries with the metabolic syndrome. This study examined the association of sexual function with metabolic syndrome and cardiovascular disease in healthy older women.
   METHODS: There were 376 postmenopausal, community-dwelling women from the Rancho Bernardo Study (mean baseline age = 73 years) that completed a clinic visit during 1999-2002 and returned the Female Sexual Function Index (FSFI) questionnaire mailed in 2002.
   RESULTS: Thirty-nine percent reported being sexually active; 41.5% met a diagnosis of metabolic syndrome. The number of metabolic syndrome components was strongly associated with decreased sexual activity, desire, and low sexual satisfaction. Waist girth, diabetes, and hypertension were associated with decreased sexual activity. Elevated triglycerides were associated with low desire. Among the cardiovascular endpoints, heart attack, coronary artery bypass, and angina were associated with decreased sexual activity, but not with sexual desire or satisfaction. Past diagnosis of heart failure, poor circulation, and stroke were not associated with sexual function. Sexually active women with metabolic syndrome met criteria for sexual dysfunction in desire, arousal, orgasm, and satisfaction domains. The FSFI Total Score did not differ significantly between sexually active and inactive women.
   CONCLUSIONS: Metabolic syndrome was associated with decreased sexual activity, desire, and satisfaction in all women and with sexual dysfunction in most domains in sexually active women. Coronary artery disease was more prevalent in women with low sexual activity. (C) 2016 Elsevier Inc. All rights reserved.
C1 [Trompeter, Susan E.] Univ Calif San Diego, Dept Med, Div Gen Internal Med, La Jolla, CA 92093 USA.
   [Trompeter, Susan E.] Vet Affairs San Diego Healthcare Syst, San Diego, CA USA.
   [Bettencourt, Ricki; Barrett-Connor, Elizabeth] Univ Calif San Diego, Dept Family Med & Publ Hlth, Div Epidemiol, 9500 Gilman Dr,MC 0607, La Jolla, CA 92093 USA.
C3 University of California System; University of California San Diego; US
   Department of Veterans Affairs; Veterans Health Administration (VHA); VA
   San Diego Healthcare System; University of California System; University
   of California San Diego
RP Barrett-Connor, E (corresponding author), Univ Calif San Diego, Dept Family Med & Publ Hlth, Div Epidemiol, 9500 Gilman Dr,MC 0607, La Jolla, CA 92093 USA.
EM ebarrettconnor@ucsd.edu
RI Bettencourt, Ricki/M-3531-2019
FU National Institutes of Health/National Institute on Aging [AG07181,
   AG028507]; National Institute of Diabetes and Digestive and Kidney
   Diseases [DK31801]
FX The Rancho Bernardo Study has been supported by National Institutes of
   Health/National Institute on Aging grants AG07181 and AG028507 and the
   National Institute of Diabetes and Digestive and Kidney Diseases, grant
   DK31801. This financial support does not represent a conflict of
   interest; the funding sources had no involvement in study design,
   collection, analysis, and interpretation of data, writing of the paper,
   or decision to submit for publication.
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NR 38
TC 27
Z9 31
U1 0
U2 2
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0002-9343
EI 1555-7162
J9 AM J MED
JI Am. J. Med.
PD DEC
PY 2016
VL 129
IS 12
BP 1270
EP U179
DI 10.1016/j.amjmed.2016.03.039
PG 9
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA EI6QB
UT WOS:000392619500027
PM 27132570
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Esfahani, M
   Movahedian, A
   Baranchi, M
   Goodarzi, MT
AF Esfahani, Maryam
   Movahedian, Ahmad
   Baranchi, Mostafa
   Goodarzi, Mohammad Taghi
TI Adiponectin: an adipokine with protective features against metabolic
   syndrome
SO IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
LA English
DT Article
DE Adiponectin; Atherosclerosis; Hypertension; Inflammation; Metabolic
   syndrome; Oxidative stress
ID ACTIVATED PROTEIN-KINASE; C-REACTIVE PROTEIN; MOLECULAR-WEIGHT
   ADIPONECTIN; ADIPOSE-TISSUE LIPOLYSIS; LIFE-STYLE MODIFICATION;
   FATTY-ACID OXIDATION; PROCOLLAGEN TYPE-I; PLASMA ADIPONECTIN;
   INSULIN-RESISTANCE; SERUM ADIPONECTIN
AB Metabolic syndrome (MetS) as a collection of obesity-associated disorders is associated with inflammation, oxidative stress, pro-thrombotic state, elevated risk of developing cardiovascular disease and type 2 diabetes. Adiponectin is one of the most abundant peptide hormones derived from adipose tissue. This protein plays a major role in glucose and lipid metabolism and prevents development of vascular changes. Anti-oxidative and anti-inflammatory effects are the other features of adiponectin. Hypoadiponectinemia is associated with hypertension and pro-thrombotic state. In this review, we discuss the crucial role of adiponectin in prevention of metabolic syndrome considering its effects on the components of this syndrome. Pharmacological interventions and lifestyle modification may increase plasma adiponectin level or tissue sensitivity which seems to be a promising target for prevention and therapeutic approaches of MetS and related diseases.
C1 [Esfahani, Maryam; Movahedian, Ahmad] Isfahan Univ Med Sci, Fac Pharm, Dept Clin Biochem, Esfahan, Iran.
   [Baranchi, Mostafa] Tarbiat Modares Univ, Dept Phys Educ & Sports Sci, Tehran, Iran.
   [Goodarzi, Mohammad Taghi] Hamadan Univ Med Sci, Res Ctr Mol Med, Hamadan, Iran.
C3 Isfahan University of Medical Sciences; Tarbiat Modares University;
   Hamadan University of Medical Sciences
RP Goodarzi, MT (corresponding author), Hamadan Univ Med Sci, Res Ctr Mol Med, Hamadan, Iran.
EM mt.goodarzi@umsha.ac.ir
RI Goodarzi, Mohammad/AAC-8798-2019; Baranchi, Mostafa/K-3177-2017
OI Baranchi, Mostafa/0000-0003-3485-6571; Goodarzi, Mohammad
   Taghi/0000-0002-5546-5812
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NR 168
TC 78
Z9 89
U1 0
U2 17
PU MASHHAD UNIV MED SCIENCES
PI MASHHAD
PA VICE-CHANCELLOR FOR RES CTR OFF IJBMS, DANESHGAH ST, PO BOX 9138813944 -
   445, MASHHAD, 00000, IRAN
SN 2008-3866
EI 2008-3874
J9 IRAN J BASIC MED SCI
JI Iran. J. Basic Med. Sci.
PD MAY
PY 2015
VL 18
IS 5
BP 430
EP 442
PG 13
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA CN5WT
UT WOS:000358504300002
PM 26124928
DA 2025-06-11
ER

PT J
AU Owari, Y
AF Owari, Yutaka
TI Relationship between Psychological Distress and Prolonged Sedentary
   Bouts in the Elderly: Four Period Analysis
SO HEALTHCARE
LA English
DT Article
DE psychological distress; prolonged sedentary bouts; the elderly;
   structural equation modelling (SEM)
ID QUALITY-OF-LIFE; PHYSICAL-ACTIVITY; METABOLIC SYNDROME; SITTING TIME;
   ADULTS; RISK; ASSOCIATION; DEPRESSION; BREAKING; BEHAVIOR
AB Background: Too much sitting is associated with low mental health in elderly individuals. We clarified the relationship between psychological distress and the rate of prolonged sedentary bouts (PSBs) among the elderly over four periods. Methods: In a secondary analysis, a sample population of 68 adults aged 65 years or older in Japan was used. The following proxy variables were used: PSB (mental health) and the Kessler 6 scale; K6 scores (psychological distress). Results: Using the cross-lagged effects models, from "2016 K6" to "2017 PSB" (p = 0.004), from "2017 K6" to "2018 PSB" (p < 0.001), and from "2018 K6" to "2019 PSB" (p = 0.021) were all significant; however, the reverse were not all significant in one period. In four periods, from "2016 PSB" to "2019 K6" (p = 0.025) was significant; however, the reverse was not significant. Fit indices were obtained: chi(2) = 7.641 (p = 0.182), goodness of fit index (GFI) = 0.891, comparative fit index (CFI) = 0.901, and root mean square error of approximation (RMSEA) = 0.121 in structural equation modelling. Conclusions: Psychological distress may affect the rate of PSB after one year, and the rate of PSB may affect the rate of psychological distress after three years in elderly individuals.
C1 [Owari, Yutaka] Shikoku Med Coll, Utadu, Kagawa 7690205, Japan.
RP Owari, Y (corresponding author), Shikoku Med Coll, Utadu, Kagawa 7690205, Japan.
EM seikotsuin@nifty.com
OI Owari, Yutaka/0000-0002-6978-6705
CR Alkhajah TA, 2012, AM J PREV MED, V43, P298, DOI 10.1016/j.amepre.2012.05.027
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NR 30
TC 0
Z9 0
U1 1
U2 8
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2227-9032
J9 HEALTHCARE-BASEL
JI Healthcare
PD JUN
PY 2021
VL 9
IS 6
AR 676
DI 10.3390/healthcare9060676
PG 8
WC Health Care Sciences & Services; Health Policy & Services
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services
GA SZ7KT
UT WOS:000666740000001
PM 34200000
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Jin, H
   Lanouette, NM
   Mudaliar, S
   Henry, R
   Folsom, DP
   Khandrika, S
   Glorioso, DK
   Jeste, DV
AF Jin, Hua
   Lanouette, Nicole M.
   Mudaliar, Sunder
   Henry, Robert
   Folsom, David P.
   Khandrika, Srikriskna
   Glorioso, Danielle K.
   Jeste, Dilip V.
TI Association of Posttraumatic Stress Disorder With Increased Prevalence
   of Metabolic Syndrome
SO JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
LA English
DT Article
DE PTSD; psychotic disorders; metabolic syndrome
ID CORONARY-HEART-DISEASE; ATYPICAL ANTIPSYCHOTICS; CLINICAL-TRIALS;
   OLANZAPINE; VETERANS; ILLNESS; SCHIZOPHRENIA; CLOZAPINE; MORBIDITY;
   SYMPTOMS
AB Objective: Few studies have compared prevalence rates of metabolic abnormalities in antipsychotic-treated patients with different psychiatric disorders, including posttraumatic stress disorder (PTSD). In this study, we examined components of metabolic syndrome among middle-aged and older patients with psychiatric disorders.
   Method: In the study, 203 outpatients older than 40 years and with psychotic symptoms that needed antipsychotic treatment were enrolled. Among them, 65 had a diagnosis of schizophrenia, 56 had dementia, 49 had mood disorder, and 33 had PTSD. Clinical evaluations included medical history, use of psychotropic and other medications, adverse effects, physical examination, and clinical laboratory tests for metabolic profiles.
   Results: Overall, the prevalence rates of metabolic syndrome were 72% in patients with PTSD, 60% in those with schizophrenia, 58% in those with mood disorder, and 56% in those with dementia. There were significant differences in body mass index, diastolic blood pressure, waist circumference, and high-density lipoprotein cholesterol among the 4 diagnostic groups. Posttraumatic stress disorder, schizophrenia, and mood disorder groups had significantly higher body mass indexes compared with the dementia group. The PTSD group also had significantly higher diastolic blood pressure compared with the dementia and mood disorder groups.
   Conclusions: Posttraumatic stress disorder may be associated with worsened metabolic profile. The overall frequency of metabolic syndrome and its components in patients with PTSD taking antipsychotics seemed to be at least equivalent, if not slightly worse, compared with that in patients with schizophrenia, dementia, or a mood disorder.
C1 [Jin, Hua] Univ Calif San Diego, Dept Psychiat, VA San Diego Healthcare Syst, San Diego, CA 92161 USA.
   [Jin, Hua; Glorioso, Danielle K.; Jeste, Dilip V.] VA San Diego Healthcare System, Psychiat Serv, San Diego, CA USA.
   [Mudaliar, Sunder; Henry, Robert] Univ Calif San Diego, Dept Med, Div Endocrinol, San Diego, CA 92161 USA.
   [Folsom, David P.] Univ Calif San Diego, Dept Family & Prevent Med, San Diego, CA 92161 USA.
   [Khandrika, Srikriskna] Univ Calif San Diego, Gen Clin Res Ctr, Core Lab, San Diego, CA 92161 USA.
C3 University of California System; University of California San Diego; US
   Department of Veterans Affairs; Veterans Health Administration (VHA); VA
   San Diego Healthcare System; US Department of Veterans Affairs; Veterans
   Health Administration (VHA); VA San Diego Healthcare System; University
   of California System; University of California San Diego; University of
   California System; University of California San Diego; University of
   California System; University of California San Diego
RP Jin, H (corresponding author), Univ Calif San Diego, Dept Psychiat, VA San Diego Healthcare Syst, 3350 La Jolla Village Dr MC-116A, San Diego, CA 92161 USA.
EM hjin@ucsd.edu
RI Henry, Robert/B-5824-2008; jin, hua/AAX-1569-2020; Mudaliar,
   Sunder/N-5813-2019
FU National Institute of Mental Health [MH071536, T32 MH019934-12, P30
   MH080002-01]; Department of Veterans Affairs
FX This study is supported, in part, by the National Institute of Mental
   Health (grants MH071536, T32 MH019934-12, and P30 MH080002-01) and by
   the Department of Veterans Affairs.
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NR 56
TC 49
Z9 51
U1 0
U2 10
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0271-0749
EI 1533-712X
J9 J CLIN PSYCHOPHARM
JI J. Clin. Psychopharmacol.
PD JUN
PY 2009
VL 29
IS 3
BP 210
EP 215
DI 10.1097/JCP.0b013e3181a45ed0
PG 6
WC Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Psychiatry
GA 445VF
UT WOS:000266078900003
PM 19440072
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Mahdavifard, S
   Nakhjavani, M
AF Mahdavifard, Sina
   Nakhjavani, Manouchehr
TI Supplementation with cysteine improved metabolic syndrome in rats by
   increasing antioxidant potential in the liver and adipose tissue, as
   well as decreasing hepatic NF-κB expression
SO FOOD BIOSCIENCE
LA English
DT Article
DE Cysteine; Glutathione; Insulin resistance; Nuclear factor-k beta;
   Carbonyl stress; Metabolic syndrome
ID OXIDATIVE STRESS; LIPID-PEROXIDATION; INSULIN-RESISTANCE; OBESITY; BETA
AB Insulin resistance is a key characteristic of metabolic syndrome (MetS). The hepatic nuclear factor- kappa B (NF-kappa B) signaling pathway plays a crucial role in insulin resistance and the development of type 2 diabetes. Our study aimed to examine the impact of cysteine (Cys) on various biochemical and histopathological parameters in the liver and kidney, hepatic NF-k beta expression, oxidative stress, inflammation, glycation, carbonyl stress markers, and insulin resistance. The study involved four groups of rats, each consisting of seven rats: a control group, a MetS group, and two similar groups receiving Cys treatment. Metabolic syndrome was induced in rats by administering a 40% sucrose solution, while, the treated groups received 50 mg/L Cys in their drinking water. Various factors, including body weight, hepatic NF-k beta expression, levels of antioxidants, anti-glycation, oxidative stress, carbonyl stress, inflammatory, anti-glycation, and glycation markers were assessed in blood and tissues. Liver and kidney function parameters and metabolic profiles were measured. Finally, liver tissue was also evaluated by a pathologist. The results showed that Cys reduced hepatic NF-k beta expression, oxidative stress, inflammation, glycation and carbonyl stress markers, as well as liver fatty content, blood sugar levels, insulin resistance, cardiovascular risk index, and body weight. The treatment also mitigated histopathological liver changes and acute hepatitis (p < 0.001). Cysteine exhibited anti-obesity and anti-atherosclerotic effects, improved beta-cell function, insulin sensitivity, and lipid metabolism, and enhanced liver and kidney function, as well as prevented acute hepatitis by restoring the GSH/GSSG ratio, hepatic NF-k beta signaling, and carbonyl stress.
C1 [Mahdavifard, Sina] Ardabil Univ Med Sci, Dept Clin Biochem, POB 56189-85991, Ardebil, Iran.
   [Nakhjavani, Manouchehr] Univ Tehran Med Sci, Vali Asr Hosp, Endocrinol & Metab Endocrine Div, Tehran, Iran.
C3 Ardabil University of Medical Sciences; Tehran University of Medical
   Sciences
RP Mahdavifard, S (corresponding author), Ardabil Univ Med Sci, Dept Clin Biochem, POB 56189-85991, Ardebil, Iran.
EM sina.mahdavifard@arums.ac.ir
RI Nakhjavani, Manouchehr/J-3704-2019; Mahdavifard, Sina/A-1038-2018
OI Mahdavifard, Sina/0000-0001-9878-2984
FU Ardabil University of Medical Sciences [IR.ARUMS. AEC.1401.029]
FX The authors declare the following financial interests/personal
   re-lationships which may be considered as potential competing interests:
   Dr Sina Mahdavifard reports financial support was provided by Ardabil
   University of Medical Sciences. Dr Sina Mahdavifard reports a
   relationship with Ardabil University of Medical Sciences that includes:
   funding grants. Dr Sina Mahdavifard has patent #IR.ARUMS. AEC.1401.029
   pending to IR.ARUMS.AEC.1401.029. Co-author: Kimia Hazrat Gholizadeh
   Namin, Faculty of Medicine, Ardabil University of Medical Sciences,
   Ardabil, Iran If there are other authors, they declare that they have no
   known competing financial interests or personal re-lationships that
   could have appeared to influence the work reported in this paper.
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NR 45
TC 0
Z9 0
U1 1
U2 2
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2212-4292
EI 2212-4306
J9 FOOD BIOSCI
JI Food Biosci.
PD DEC
PY 2024
VL 62
AR 105123
DI 10.1016/j.fbio.2024.105123
EA SEP 2024
PG 6
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA H1O6I
UT WOS:001321205700001
DA 2025-06-11
ER

PT J
AU Harada, N
AF Harada, Naoki
TI Role of androgens in energy metabolism affecting on body composition,
   metabolic syndrome, type 2 diabetes, cardiovascular disease, and
   longevity: lessons from a meta-analysis and rodent studies
SO BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
LA English
DT Article
DE Testosterone; androgen; systematic review and meta-analysis; metabolic
   syndrome and type 2 diabetes; cardiovascular disease
ID LATE-ONSET HYPOGONADISM; TESTOSTERONE REPLACEMENT THERAPY; MALE
   SEXUAL-DIFFERENTIATION; RECEPTOR AR COREGULATORS; PANCREATIC BETA-CELL;
   MIDDLE-AGED MEN; DEPRIVATION THERAPY; MALE-MICE; PROSTATE-CANCER; GUT
   MICROBIOTA
AB Testosterone is a sex hormone produced by testicular Leydig cells in males. Blood testosterone concentrations increase at three time-periods in male life-fetal, neonatal (which can be separated into newborn and infant periods), and pubertal stages. After peaking in the early 20s, the blood bioactive testosterone level declines by 1-2% each year. It is increasingly apparent that a low testosterone level impairs general physical and mental health in men. Here, this review summarizes recent systematic reviews and meta-analyses of epidemiological studies in males (including cross-sectional, longitudinal, and androgen deprivation studies, and randomized controlled testosterone replacement trials) in relation to testosterone and obesity, body composition, metabolic syndrome, type 2 diabetes, cardiovascular disease, and longevity. Furthermore, underlying mechanisms are discussed using data from rodent studies involving castration or androgen receptor knockout. This review provides an update understanding of the role of testosterone in energy metabolism.Abbreviations AR: androgen receptor; CV: cardiovascular; FDA: US Food and Drug Administration; HFD: high-fat diet; KO: knockout; MetS: metabolic syndrome; RCT: randomized controlled trial; SHBG: sex hormone binding globulin; SRMA: systematic review and meta-analysis; TRT: testosterone replacement therapy; T2DM:type 2 diabetes mellitus
C1 [Harada, Naoki] Osaka Prefecture Univ, Grad Sch Life & Environm Sci, Div Appl Life Sci, Sakai, Osaka, Japan.
C3 Osaka Metropolitan University
RP Harada, N (corresponding author), Osaka Prefecture Univ, Grad Sch Life & Environm Sci, Div Appl Life Sci, Sakai, Osaka, Japan.
EM harada@biochem.osakafu-u.ac.jp
RI Harada, Naoki/AAP-2868-2020
OI Harada, Naoki/0000-0003-3846-388X
FU Japan Society for the Promotion of Science (JSPS KAKENHI) [16K07743]
FX This work was supported by Grants-in-Aid for scientific research from
   the Japan Society for the Promotion of Science (JSPS KAKENHI)
   [16K07743].
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NR 181
TC 28
Z9 30
U1 1
U2 21
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0916-8451
EI 1347-6947
J9 BIOSCI BIOTECH BIOCH
JI Biosci. Biotechnol. Biochem.
PY 2018
VL 82
IS 10
BP 1667
EP 1682
DI 10.1080/09168451.2018.1490172
PG 16
WC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
   Chemistry, Applied; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology;
   Chemistry; Food Science & Technology
GA GU4GF
UT WOS:000445240200001
PM 29957125
OA Bronze
DA 2025-06-11
ER

PT J
AU Arteche-Hidalgo, L
   Fernandez-Travieso, JC
   Suarez-Camejo, N
   Marin-Preval, J
   Alvarez-Acosta, V
   Chaviano-Pereira, J
   Garcia-Sanchez, M
   Esquivel-Moinelo, I
   Diaz-Gonzalez, M
   Matos-Reyes, O
   Fernandez-Dorta, L
   Illnait-Ferrer, J
   Mendoza-Castano, S
   Monzon-Perez, M
   Pedroso, VS
AF Arteche-Hidalgo, Liuba
   Cesar Fernandez-Travieso, Julio
   Suarez-Camejo, Noysbel
   Marin-Preval, Juan
   Alvarez-Acosta, Victor
   Chaviano-Pereira, Julian
   Garcia-Sanchez, Maura
   Esquivel-Moinelo, Idelsis
   Diaz-Gonzalez, Marisol
   Matos-Reyes, Odalys
   Fernandez-Dorta, Lilia
   Illnait-Ferrer, Jose
   Mendoza-Castano, Sarahi
   Monzon-Perez, Maicel
   Sanchez Pedroso, Victoria
TI Effects of Policosanol in Patients With Metabolic Syndrome: A Six-Month
   Study
SO JOURNAL OF ENDOCRINOLOGY AND METABOLISM
LA English
DT Article
DE Policosanol; Metabolic syndrome; Oxidative stress; Redox index; Lipid
   profile
ID LIPID-PEROXIDATION; PLATELET-AGGREGATION; OXIDATIVE STRESS; CORONARY
   RISK; HYPERCHOLESTEROLEMIA; SUSCEPTIBILITY; CHOLESTEROL; PRODUCTS;
   PROFILE
AB Background: The metabolic syndrome comprises a set of cardiovascular risk factors represented by obesity of central distribution, dyslipidemias, glucose metabolism abnormalities and arterial hypertension, closely associated with insulin resistance. Policosanol is a mixture of high molecular weight alcohols purified from sugar cane wax with cholesterol-lowering and antioxidant effects. The aim of this study is to investigate in the medium term the effects of policosanol in patients with metabolic syndrome, as well as its safety and tolerability.
   Methods: This phase IV study had a double-blind, randomized and controlled design, with two parallel groups that received policosanol (10 mg/day) or placebo for 6 months. The study included patients with metabolic syndrome, of both sexes, aged between 25 and 70 years. As a primary efficacy variable, the effects on oxidative stress were evaluated, while the effects on lipids profile variables were considered as a secondary efficacy variable. Statistical analysis of the data was performed according to the intention-to-treat method.
   Results: The study included 100 patients with metabolic syndrome (81 men, 19 women) (average age: 51 years). At the end of 6 months of treatment, policosanol significantly reduced the redox index with respect to the initial values and with respect to the placebo group. Policosanol significantly reduced levels of total cholesterol and low-density lipoprotein cholesterol (LDL-C), as well as increased serum levels of high-density lipoprotein cholesterol (HDL-C), while triglyceride levels although reduced at the end of treatment, this reduction was not significant. The policosanol was safe and well tolerate; it did not affect the physical and laboratory parameters investigated, with the exception of a significant and favorable reduction in the levels of apolipoprotein (Apo) B.
   Conclusions: It is concluded that policosanol therapy for 6 months produces improvements on oxidative stress in patients with metabolic syndrome, in addition to a beneficial effect on their lipid profile, being safe and well tolerated.
C1 [Arteche-Hidalgo, Liuba; Suarez-Camejo, Noysbel; Marin-Preval, Juan; Alvarez-Acosta, Victor; Chaviano-Pereira, Julian; Garcia-Sanchez, Maura; Esquivel-Moinelo, Idelsis; Diaz-Gonzalez, Marisol; Matos-Reyes, Odalys] Luis Diaz Soto Hosp, Havana, Cuba.
   [Cesar Fernandez-Travieso, Julio; Fernandez-Dorta, Lilia; Illnait-Ferrer, Jose; Mendoza-Castano, Sarahi] Natl Ctr Sci Res, Havana, Cuba.
   [Monzon-Perez, Maicel; Sanchez Pedroso, Victoria] Natl Clin Trials Coordinator Ctr, Havana, Cuba.
   [Cesar Fernandez-Travieso, Julio] Natl Ctr Sci Res, Clin Trials Unit, 25 Ave & 158 St, Havana, Cuba.
RP Fernandez-Travieso, JC (corresponding author), Natl Ctr Sci Res, Clin Trials Unit, 25 Ave & 158 St, Havana, Cuba.
EM julio.fernandez@cnic.cu
RI Mendoza Castaño, Sarahi/IQR-9004-2023
OI Monzon-Perez, Maicel/0000-0003-2117-9145
FU National Centre for Scientific Research
FX This study was support by the National Centre for Scientific Research,
   as part of its research-development projects.
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NR 34
TC 7
Z9 7
U1 0
U2 0
PU ELMER PRESS INC
PI QUEBEC
PA 9160 BOUL LEDUC, BUREAU 410, BROSSARD, QUEBEC, J4Y 0E3, CANADA
SN 1923-2861
EI 1923-287X
J9 J ENDOCRINOL METAB
JI J. Endocrinol. Metab.
PD APR
PY 2020
VL 10
IS 2
BP 36
EP 44
DI 10.14740/jem642
PG 9
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA LM7IN
UT WOS:000532422100003
OA gold
DA 2025-06-11
ER

PT J
AU Kuribara, T
   Imagawa, A
   Hirano, M
   Ito, Y
   Totani, K
AF Kuribara, Taiki
   Imagawa, Ayami
   Hirano, Makoto
   Ito, Yukishige
   Totani, Kiichiro
TI Metabolic syndrome perturbs deglucosylation and reglucosylation in the
   glycoprotein folding cycle
SO FEBS LETTERS
LA English
DT Article
DE diabetes; glycoenzyme; glycoprotein quality control; obesity;
   trans-omics
ID ENDOPLASMIC-RETICULUM STRESS; II BETA-SUBUNIT; GLUCOSIDASE-II;
   QUALITY-CONTROL; MOLECULAR CHAPERONE; MESSENGER-RNA; SENSOR ENZYME; ER;
   RAT; GLUCOSYLTRANSFERASE
AB Deglucosylation and reglucosylation of glycoproteins by glucosidase II and uridine diphosphate-glucose: glycoprotein glucosyltransferase 1 (UGGT1), respectively, are important steps in glycoprotein quality control. Misfolded glycoprotein accumulation is associated with endoplasmic reticulum stress and can lead to protein misfolding diseases such as metabolic syndrome. Here, we analyzed the expression and activities of glucosidase II and UGGT1 in rat models of obesity and obese type 2 diabetes, and phenotypes associated with moderate and severe metabolic syndrome, respectively. In obesity, the mRNA and protein levels of glucosidase II and UGGT1 are decreased and their activities are reduced. In obese type 2 diabetes, the mRNA and protein levels of these enzymes are increased, and glucosidase II activity is slightly recovered, although UGGT1 activity is reduced. Our findings suggest that metabolic syndrome affects deglucosylation/reglucosylation enzymes according to disease severity.
C1 [Kuribara, Taiki; Imagawa, Ayami; Totani, Kiichiro] Seikei Univ, Dept Mat & Life Sci, 3-3-1 Kichijoji Kitamachi, Tokyo 1808633, Japan.
   [Hirano, Makoto] Yasuda Womens Univ, Dept Pharm, Hiroshima, Japan.
   [Ito, Yukishige] RIKEN, Synthet Cellular Chem Lab, Wako, Saitama, Japan.
C3 Seikei University; RIKEN
RP Totani, K (corresponding author), Seikei Univ, Dept Mat & Life Sci, 3-3-1 Kichijoji Kitamachi, Tokyo 1808633, Japan.
EM ktotani@st.seikei.ac.jp
RI Ito, Yukishige/M-5119-2014
OI Ito, Yukishige/0000-0001-6251-7249; Totani, Kiichiro/0000-0002-4957-1686
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NR 41
TC 8
Z9 8
U1 0
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0014-5793
EI 1873-3468
J9 FEBS LETT
JI FEBS Lett.
PD JUN
PY 2020
VL 594
IS 11
BP 1759
EP 1769
DI 10.1002/1873-3468.13780
PG 11
WC Biochemistry & Molecular Biology; Biophysics; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Cell Biology
GA LV7KG
UT WOS:000538615100011
PM 32232844
OA Bronze
DA 2025-06-11
ER

PT J
AU Rosenthal, TR
   Park, SK
   Kairamkonda, S
   Khatoon, S
   Pop, LM
   Bobulescu, IA
AF Rosenthal, Tara R.
   Park, Sun K.
   Kairamkonda, Subash
   Khatoon, Sabiha
   Pop, Laurentiu M.
   Bobulescu, Ion Alexandru
TI Renal lipid accumulation, oxidative stress and uric acid handling in a
   rodent model of obesity and metabolic syndrome
SO JOURNAL OF INVESTIGATIVE MEDICINE
LA English
DT Article
DE obesity; kidney diseases; antioxidants; lipids
AB Hyperuricemia is more prevalent among people with obesity and metabolic syndrome, and is associated with adverse clinical outcomes. We hypothesized that increased renal reabsorption of uric acid (UA) in obesity and metabolic syndrome may be an adaptive response of the kidney when faced with fatty acid-induced oxidative stress. To test this hypothesis, we examined lipid accumulation, markers of oxidative stress, and renal UA handling in Zucker diabetic fatty (ZDF) rats, and in matched lean control animals. Rats were randomized to either normal rodent chow or a diet supplemented with antioxidants (alpha-tocopheryl acetate, sodium selenite, zinc sulfate, and ascorbic acid), and were followed up for either 4 or 20 weeks after randomization. Dietary antioxidant supplementation had no significant effects in lean control rats but led to partial improvement in markers of elevated oxidative stress in the kidney of ZDF rats. Renal UA handling was not affected by antioxidant supplementation. We observed robust correlations between renal lipid content and oxidative stress markers in the pooled experimental groups, particularly in older animals after 20 weeks on the study diets. Dietary antioxidant supplementation did not prevent the gradual decline in renal function observed in older ZDF rats. These findings suggest that hyperuricemia in the ZDF rat model of obesity and the metabolic syndrome is not caused by renal oxidative stress, that there may be a pathophysiological link between lipid accumulation and oxidative stress in the kidney, and that antioxidant supplementation does not prevent age-related decline in renal function in ZDF rats.
C1 [Rosenthal, Tara R.; Park, Sun K.] Univ Texas Southwestern Med Ctr Dallas, Internal Med, Dallas, TX 75390 USA.
   [Kairamkonda, Subash; Khatoon, Sabiha; Bobulescu, Ion Alexandru] Texas Tech Univ, Hlth Sci Ctr, Cell Biol & Biochem, Lubbock, TX 79409 USA.
   [Pop, Laurentiu M.] Univ Texas Southwestern Med Ctr Dallas, Radiat Oncol, Dallas, TX 75390 USA.
   [Bobulescu, Ion Alexandru] Texas Tech Univ, Hlth Sci Ctr, Internal Med, Lubbock, TX 79409 USA.
C3 University of Texas System; University of Texas Southwestern Medical
   Center Dallas; Texas Tech University System; Texas Tech University
   Health Sciences Center Lubbock; University of Texas System; University
   of Texas Southwestern Medical Center Dallas; Texas Tech University
   System; Texas Tech University Health Sciences Center Lubbock
RP Bobulescu, IA (corresponding author), Texas Tech Univ, Hlth Sci Ctr, Lubbock, TX 79409 USA.
EM ion.a.bobulescu@ttuhsc.edu
RI Kairamkonda, Subash/ADB-1991-2022; Pop, Laurentiu/N-5416-2019; Khatoon,
   Sabiha/AEG-8656-2022
OI Bobulescu, Ion Alexandru/0000-0002-3994-1567
FU National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
   [R01-DK113377]; Southwestern Medical Foundation's Haberecht Wild-Hare
   Idea Research Program; NIDDK [P30-DK079328]
FX IAB was supported by the National Institute of Diabetes and Digestive
   and Kidney Diseases (NIDDK, grant R01-DK113377), with additional support
   from Southwestern Medical Foundation's Haberecht Wild-Hare Idea Research
   Program. The UT Southwestern O'Brien Kidney Research Core Center was
   supported by NIDDK (grant P30-DK079328).
CR Bobulescu A, 2012, ADV CHRONIC KIDNEY D, V19, P358, DOI 10.1053/j.ackd.2012.07.009
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NR 38
TC 8
Z9 8
U1 0
U2 12
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 1081-5589
EI 1708-8267
J9 J INVEST MED
JI J. Invest. Med.
PD APR
PY 2021
VL 69
IS 4
BP 863
EP 869
DI 10.1136/jim-2020-001608
PG 7
WC Medicine, General & Internal; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Research & Experimental Medicine
GA RJ8OO
UT WOS:000637859900012
PM 33323390
DA 2025-06-11
ER

PT J
AU Siba, IP
   Martynhak, BJ
   Pereira, M
AF Siba, Isadora P.
   Martynhak, Bruno J.
   Pereira, Marcela
TI When Gut Hormones Influence Brain Function in Depression
SO APPLIED BIOSCIENCES
LA English
DT Review
DE microbiome; brain; hormones; depression; circadian rhythm
ID CHAIN FATTY-ACIDS; GLUCAGON-LIKE PEPTIDE-1;
   VASOACTIVE-INTESTINAL-PEPTIDE; IRRITABLE-BOWEL-SYNDROME; EARLY-LIFE
   STRESS; METABOLIC SYNDROME; REACTIVE AUTOANTIBODIES; MICROBIOTA
   INTERACTIONS; ENTEROENDOCRINE CELLS; ALZHEIMERS-DISEASE
AB The literature on the crosstalk between the brain and the gut has increased considerably in recent years. It is widely accepted now that the microbiome plays a significant role in several brain disorders, neurodevelopment, neurocognitive stages, and physiological functions. However, the mechanisms that influence such crosstalk are still not well elucidated. In this sense, one of the possible mechanisms by which the microbiome could influence brain function is through gut hormones released by enteroendocrine cells: ghrelin, cholecystokinin (CCK), peptide YY (PYY), vasoactive intestinal polypeptide (VIP), glucagon-like peptide (GLP1-2), corticotropin-releasing factor (CRF), glucose-dependent insulinotropic polypeptide (GIP), secretin, serotonin (5-HT), and oxytocin. Especially when one considers that the brain expresses receptors for these hormones in areas important to the neurobiology of brain disorders (e.g., depression), such as the hippocampus, amygdala, hypothalamus, and suprachiasmatic nucleus. To strengthen this hypothesis, gastrointestinal dysfunction (such as altered motility or pain) is relatively common in depressive patients, and changes in diet (low-carbohydrate diets, for example) positively affect mood. Additionally, alterations in the gut microbiome are relatively common in depressive patients and are related to the levels of Akkermansia, Lactobacillus, Bifidobacteria, Faecalibacterium, Roseburia and Clostridium. Finally, concerning the gut-released hormones, the literature reports that ghrelin can be a peripheral marker for the antidepressant treatment success rate and has elevated levels during depression. GLP-1 is tightly correlated with HPA axis activity being decreased by high cortisol levels. CCK seems to be altered in depression due to increased inflammation and activation of Toll-like receptor 4. Such finds allow the postulation that hormones, the microbiome and mood are intertwined and co-dependent. VIP is correlated with circadian rhythms. There is a bidirectional connection of the circadian rhythms between the host and the microbiota. Circadian rhythm disruption is associated with both poor outcomes in mental health and alterations in the microbiota composition. In sum, in the past year, more and more research has been published showing the tight connection between gut and brain health and trying to decipher the feedback in play. Here, we focus on depression.
C1 [Siba, Isadora P.] Univ Fed Parana, Dept Pharmacol, BR-81531980 Curitiba, Brazil.
   [Martynhak, Bruno J.] Univ Fed Parana, Dept Physiol, BR-81531980 Curitiba, Brazil.
   [Pereira, Marcela] Karolinska Inst, Dept Microbiol Tumor & Cell Biol, S-17165 Solna, Sweden.
C3 Universidade Federal do Parana; Universidade Federal do Parana;
   Karolinska Institutet
RP Pereira, M (corresponding author), Karolinska Inst, Dept Microbiol Tumor & Cell Biol, S-17165 Solna, Sweden.
EM marcela.pereira@ki.se
RI Martynhak, Bruno/F-6741-2012
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NR 197
TC 0
Z9 0
U1 0
U2 0
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2813-0464
J9 APPL BIOSCI-BASEL
JI Appl. Biosci.
PD FEB 1
PY 2023
VL 2
IS 1
BP 31
EP 51
DI 10.3390/applbiosci2010005
PG 21
WC Biotechnology & Applied Microbiology
WE Emerging Sources Citation Index (ESCI)
SC Biotechnology & Applied Microbiology
GA 2OZ0H
UT WOS:001487854000001
OA gold
DA 2025-06-11
ER

PT J
AU Hopps, E
   Caimi, G
AF Hopps, Eugenia
   Caimi, Gregorio
TI Protein Oxidation in Metabolic Syndrome
SO CLINICAL AND INVESTIGATIVE MEDICINE
LA English
DT Review
ID TYPE-2 DIABETIC-PATIENTS; SPONTANEOUSLY HYPERTENSIVE-RATS; VITAMIN-E;
   INSULIN-RESISTANCE; CARDIOVASCULAR-DISEASE; LIPOPROTEIN OXIDATION;
   DEGRADATION-PRODUCTS; LIPID-PEROXIDATION; CARBONYL STRESS; END-PRODUCTS
AB Purpose: Oxidative stress plays a pivotal role in the pathogenesis of the metabolic syndrome and in the progression of its complications. Carbonylated proteins are a stable marker of severe oxidative stress because damage to the protein structure is irreversible and may cause an inhibition of their enzymatic activity or an increased susceptibility to proteolysis. There are few data regarding protein oxidation in metabolic syndrome, although elevated levels of carbonyl groups are often detected in subjects with obesity, diabetes mellitus, hypertension or dyslipidemia, well-known components of the metaboic syndrome. In particular, obesity, insulin resistance and diabetes mellitus are frequently associated with increased protein carbonylation. A relationship between insulin resistance, protein oxidative stress and inflammation has also been suggested as well as protein oxidation products are correlated with overexpression of resistin, TNF-alpha and IL-6.
   Conclusion: Therapeutic interventions based on lifestyle modifications and pharmacological agents in order to correct all the main risk factors influence oxidative stress and protein carbonylation.
C1 [Hopps, Eugenia; Caimi, Gregorio] Univ Palermo, Dept Internal & Specialist Med, I-90127 Palermo, Italy.
C3 University of Palermo
RP Hopps, E (corresponding author), Univ Palermo, Dept Internal & Specialist Med, Via Vespro 129, I-90127 Palermo, Italy.
EM euhopps@libero.it
OI Caimi, Gregorio/0000-0001-8964-255X
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NR 82
TC 20
Z9 21
U1 0
U2 8
PU CANADIAN SOC CLINICAL INVESTIGATION
PI OTTAWA
PA CSCI HEAD OFFICE, 774 ECHO DRIVE, OTTAWA, ON K1S 5N8, CANADA
SN 0147-958X
EI 1488-2353
J9 CLIN INVEST MED
JI Clin. Invest. Med.
PY 2013
VL 36
IS 1
BP E1
EP E8
PG 8
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 141YW
UT WOS:000318763600001
PM 23374595
DA 2025-06-11
ER

PT J
AU Saylor, J
   Friedmann, E
AF Saylor, Jennifer
   Friedmann, Erika
TI Biopsychosocial Contributors to Metabolic Syndrome A Secondary
   Analysis of 2007-2010 National Health and Nutrition Examination Survey
   Data
SO NURSING RESEARCH
LA English
DT Article
DE biopsychosocial model; complex sample analysis; metabolic syndrome;
   NHANES
ID QUALITY-OF-LIFE; PHYSICAL-ACTIVITY; MAJOR DEPRESSION; NATIONAL-HEALTH;
   HEART-DISEASE; PREVALENCE; ADULTS; ASSOCIATION; WOMEN; RISK
AB Background: Metabolic syndrome (MetS) is a medical disorder that encompasses obesity, hypertension, dyslipidemia, and insulin resistance and increases the risk of type 2 diabetes, cardiovascular disease, and mortality.
   Objectives: A secondary data analysis was conducted using the National Health and Nutrition Examination Survey 2007-2010 data to evaluate the association of biopsychosocial factors with MetS among U.S. adults.
   Methods: Complex samples logistic regression models were used to estimate a parsimonious model, including contributions of biomedical, biosocial, and psychosocial factors to MetS.
   Results: According to the study's representative sample, more than 47 million Americans had MetS. Using the biopsychosocial model, the effects of biosocial and psychosocial variables, including education, smoking, low exercise, and depression, were independent predictors of MetS after controlling for the contributions of age, gender, and race.
   Discussion: There is a need for large-scale, longitudinal, and interventional studies to evaluate and alter these potential risk factors, thus reducing MetS.
C1 [Saylor, Jennifer] Univ Delaware, Sch Nursing, Newark, DE 19716 USA.
   [Friedmann, Erika] Univ Maryland, Sch Nursing, Baltimore, MD 21201 USA.
C3 University of Delaware; University System of Maryland; University of
   Maryland Baltimore
RP Saylor, J (corresponding author), Univ Delaware, Sch Nursing, 25 North Coll Ave, Newark, DE 19716 USA.
EM jsaylor@udel.edu
RI Saylor, Jennifer/ABH-2647-2020; Saylor, Jennifer/A-2318-2016
OI Saylor, Jennifer/0000-0001-8199-1333
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NR 42
TC 5
Z9 8
U1 0
U2 8
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0029-6562
EI 1538-9847
J9 NURS RES
JI Nurs. Res.
PD NOV-DEC
PY 2015
VL 64
IS 6
BP 434
EP 443
DI 10.1097/NNR.0000000000000121
PG 10
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA CV6YR
UT WOS:000364418800004
PM 26505156
DA 2025-06-11
ER

PT J
AU Gavia-García, G
   Rosado-Pérez, J
   Arista-Ugalde, TL
   Aguiñiga-Sánchez, I
   Santiago-Osorio, E
   Mendoza-Núñez, VM
AF Gavia-Garcia, Graciela
   Rosado-Perez, Juana
   Arista-Ugalde, Taide Laurita
   Aguiniga-Sanchez, Itzen
   Santiago-Osorio, Edelmiro
   Mendoza-Nunez, Victor Manuel
TI Telomere Length and Oxidative Stress and Its Relation with Metabolic
   Syndrome Components in the Aging
SO BIOLOGY-BASEL
LA English
DT Review
DE metabolic syndrome; telomere; telomerase; oxidative stress; aging;
   lifestyles
ID BODY-MASS INDEX; 3RD NATIONAL-HEALTH; DNA-DAMAGE; INSULIN-RESISTANCE;
   LIPID-PEROXIDATION; SERUM FERRITIN; US ADULTS; LONGITUDINAL
   ASSOCIATIONS; CELLULAR SENESCENCE; ANTIOXIDANT STATUS
AB Simple Summary
   A link between telomere length and some age-related diseases has been identified, including metabolic syndrome. So far, there is no mechanism to explain the origin or cause of telomere shortening in this syndrome; however, oxidative stress is a constant factor. Therefore, we reviewed scientific evidence that supported the association between oxidative stress and telomere length dynamics, also examining how each of the metabolic syndrome components individually affects the length. In this regard, there is strong scientific evidence that an increase in the number of metabolic syndrome components is associated with a shorter telomere length, oxidative damage at the lipid and DNA level, and inflammation, as well as its other components, such as obesity, hyperglycemia, and hypertension, while for dyslipidemia, there is a little more discrepancy. The difficulty for the correct treatment of metabolic syndrome lies in its multifactorial nature. Hence, there is a need to carry out more studies on healthy lifestyles during aging to prevent and reduce oxidative damage and telomere wear during aging, and consequently the progression of chronic degenerative diseases, thus improving the living conditions of older people.
   A great amount of scientific evidence supports that Oxidative Stress (OxS) can contribute to telomeric attrition and also plays an important role in the development of certain age-related diseases, among them the metabolic syndrome (MetS), which is characterised by clinical and biochemical alterations such as obesity, dyslipidaemia, arterial hypertension, hyperglycaemia, and insulin resistance, all of which are considered as risk factors for type 2 diabetes mellitus (T2DM) and cardiovascular diseases, which are associated in turn with an increase of OxS. In this sense, we review scientific evidence that supports the association between OxS with telomere length (TL) dynamics and the relationship with MetS components in aging. It was analysed whether each MetS component affects the telomere length separately or if they all affect it together. Likewise, this review provides a summary of the structure and function of telomeres and telomerase, the mechanisms of telomeric DNA repair, how telomere length may influence the fate of cells or be linked to inflammation and the development of age-related diseases, and finally, how the lifestyles can affect telomere length.
C1 [Gavia-Garcia, Graciela; Rosado-Perez, Juana; Arista-Ugalde, Taide Laurita; Mendoza-Nunez, Victor Manuel] Univ Nacl Autonoma Mexico, FES Zaragoza, Res Unit Gerontol, Mexico City 09230, DF, Mexico.
   [Aguiniga-Sanchez, Itzen; Santiago-Osorio, Edelmiro] Univ Nacl Autonoma Mexico, FES Zaragoza, Res Unit Cell Differentiat & Canc, Hematopoiesis & Leukemia Lab, Mexico City 09230, DF, Mexico.
C3 Universidad Nacional Autonoma de Mexico; Universidad Nacional Autonoma
   de Mexico
RP Mendoza-Núñez, VM (corresponding author), Univ Nacl Autonoma Mexico, FES Zaragoza, Res Unit Gerontol, Mexico City 09230, DF, Mexico.
EM ggg1501@hotmail.com; juanarosadoperez@comunidad.unam.mx;
   tdlarista@gmail.com; itzen.aguiniga@zaragoza.unam.mx; edelmiro@unam.mx;
   mendovic@unam.mx
RI Mendoza-Núñez, Víctor Manuel/AFL-2465-2022
OI Aguiniga-Sanchez, Itzen/0000-0003-1692-8287; Santiago-Osorio,
   Edelmiro/0000-0002-4876-0688; Mendoza-Nunez, Victor
   Manuel/0000-0002-9137-3405
FU National Autonomous University of Mexico (DGAPA-UNAM) [PAPIIT IN215821];
   Secretariat of Science and the Technology and Innovation Project of
   Mexico City (SECITI) [SECITI/045/2018]
FX This work was supported by grants from the General Directorate of
   Academic Personnel Affairs, National Autonomous University of Mexico
   (DGAPA-UNAM) (PAPIIT IN215821), and the Secretariat of Science and the
   Technology and Innovation Project of Mexico City (SECITI)
   (SECITI/045/2018).
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NR 316
TC 73
Z9 79
U1 2
U2 23
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2079-7737
J9 BIOLOGY-BASEL
JI Biology-Basel
PD APR
PY 2021
VL 10
IS 4
AR 253
DI 10.3390/biology10040253
PG 29
WC Biology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Life Sciences & Biomedicine - Other Topics
GA RQ9KY
UT WOS:000642731700001
PM 33804844
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Xu, J
   Kitada, M
   Ogura, Y
   Koya, D
AF Xu, Jing
   Kitada, Munehiro
   Ogura, Yoshio
   Koya, Daisuke
TI Relationship Between Autophagy and Metabolic Syndrome Characteristics in
   the Pathogenesis of Atherosclerosis
SO FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
LA English
DT Review
DE autophagy; inflammation; oxidative stress; atherosclerosis; metabolic
   syndrome; type 2 diabetes
AB Atherosclerosis is the main cause of mortality in metabolic-related diseases, including cardiovascular disease and type 2 diabetes (T2DM). Atherosclerosis is characterized by lipid accumulation and increased inflammatory cytokines in the vascular wall, endothelial cell and vascular smooth muscle cell dysfunction and foam cell formation initiated by monocytes/macrophages. The characteristics of metabolic syndrome (MetS), including obesity, glucose intolerance, dyslipidemia and hypertension, may activate multiple mechanisms, such as insulin resistance, oxidative stress and inflammatory pathways, thereby contributing to increased risks of developing atherosclerosis and T2DM. Autophagy is a lysosomal degradation process that plays an important role in maintaining cellular metabolic homeostasis. Increasing evidence indicates that impaired autophagy induced by MetS is related to oxidative stress, inflammation, and foam cell formation, further promoting atherosclerosis. Basal and mild adaptive autophagy protect against the progression of atherosclerotic plaques, while excessive autophagy activation leads to cell death, plaque instability or even plaque rupture. Therefore, autophagic homeostasis is essential for the development and outcome of atherosclerosis. Here, we discuss the potential role of autophagy and metabolic syndrome in the pathophysiologic mechanisms of atherosclerosis and potential therapeutic drugs that target these molecular mechanisms.
C1 [Xu, Jing; Kitada, Munehiro; Ogura, Yoshio; Koya, Daisuke] Kanazawa Med Univ, Dept Diabetol & Endocrinol, Uchinada, Ishikawa, Japan.
   [Xu, Jing] Guizhou Med Univ, Affiliated Hosp, Dept Endocrinol & Metab, Guiyang, Peoples R China.
   [Kitada, Munehiro; Koya, Daisuke] Kanazawa Med Univ, Med Res Inst, Div Anticipatory Mol Food Sci & Technol, Uchinada, Ishikawa, Japan.
C3 Kanazawa Medical University; Guizhou Medical University; Kanazawa
   Medical University
RP Kitada, M (corresponding author), Kanazawa Med Univ, Dept Diabetol & Endocrinol, Uchinada, Ishikawa, Japan.; Kitada, M (corresponding author), Kanazawa Med Univ, Med Res Inst, Div Anticipatory Mol Food Sci & Technol, Uchinada, Ishikawa, Japan.
EM kitta@kanazawa-med.ac.jp
RI Kovacs, Werner/AAD-1107-2019
FU Grants-in-Aid for Scientific Research [20K21773, 21K08290] Funding
   Source: KAKEN
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NR 178
TC 48
Z9 50
U1 0
U2 28
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-634X
J9 FRONT CELL DEV BIOL
JI Front. Cell. Dev. Biol.
PD APR 15
PY 2021
VL 9
AR 641852
DI 10.3389/fcell.2021.641852
PG 14
WC Cell Biology; Developmental Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Developmental Biology
GA RU8CQ
UT WOS:000645369800001
PM 33937238
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Yu, XY
   Li, Y
   Liu, TM
   Wang, RT
AF Yu, Xin-yang
   Li, Ying
   Liu, Tiemin
   Wang, Rui-tao
TI Association of whole blood viscosity with non-alcoholic fatty liver
   disease
SO CLINICAL HEMORHEOLOGY AND MICROCIRCULATION
LA English
DT Article
DE Whole blood viscosity; non-alcoholic fatty liver disease; metabolic
   syndrome
ID CARDIOVASCULAR RISK-FACTORS; METABOLIC SYNDROME; RHEOLOGY;
   ATHEROSCLEROSIS; PROGRESSION; FLOW
AB BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is an independent risk factor for increased cardiovascular disease. Altered hemorheological parameters have also been shown to play a crucial role in atherogenesis. Moreover, increased viscosity is observed in insulin resistance, metabolic syndrome, hypertension, diabetes, ischemic heart disease, and stroke. A recent study confirmed that whole blood viscosity (WBV) is a predictor of cardiovascular events.
   AIMS: This study aimed to investigate the association of WBV with NAFLD.
   METHODS: In this cross-sectional study, we investigated the relationship between WBV and NAFLD in 1329 subjects (962 men and 367 women) in a general health examination.
   RESULTS: WBVat low shear stress was elevated in patients with NAFLD. In addition, the prevalence of metabolic syndrome and NAFLD increased as WBV quartiles increased both in men and in women. Multiple regression analysis further identified WBV as an independent and significant determinant for NAFLD.
   CONCLUSIONS: The findings showed that WBV at low shear stress is increased in NAFLD. Moreover, WBV at low shear stress is independently associated with NAFLD even after adjusting other cardiovascular risk factors.
C1 [Yu, Xin-yang] Harbin Med Univ, Harbin, Heilongjiang, Peoples R China.
   [Li, Ying] Harbin Med Univ, Affiliated Hosp 2, Int Phys Examinat & Hlth Ctr, Harbin, Heilongjiang, Peoples R China.
   [Liu, Tiemin] Univ Texas SW Med Ctr Dallas, Dept Internal Med, Div Hypothalam Res, Dallas, TX USA.
   [Wang, Rui-tao] Harbin Med Univ, Affiliated Hosp 3, Dept Intens Care Unit, 150 Haping ST, Harbin 150081, Heilongjiang, Peoples R China.
C3 Harbin Medical University; Harbin Medical University; University of
   Texas System; University of Texas Southwestern Medical Center Dallas;
   Harbin Medical University
RP Wang, RT (corresponding author), Harbin Med Univ, Affiliated Hosp 3, Dept Intens Care Unit, 150 Haping ST, Harbin 150081, Heilongjiang, Peoples R China.
EM ruitaowang@126.com
RI yu, ellen/JSK-6301-2023; çŽ‹, æ/AAU-6965-2020
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NR 19
TC 6
Z9 6
U1 1
U2 11
PU IOS PRESS
PI AMSTERDAM
PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS
SN 1386-0291
EI 1875-8622
J9 CLIN HEMORHEOL MICRO
JI Clin. Hemorheol. Microcirc.
PY 2016
VL 62
IS 4
BP 335
EP 343
DI 10.3233/CH-151974
PG 9
WC Hematology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Hematology; Cardiovascular System & Cardiology
GA DR9SN
UT WOS:000380236500005
PM 26444605
DA 2025-06-11
ER

PT J
AU Lin, YC
   Lai, CL
   Chan, HY
AF Lin, Yi-Chun
   Lai, Chien-Liang
   Chan, Hung-Yu
TI The association between rehabilitation programs and metabolic syndrome
   in chronic inpatients with schizophrenia
SO PSYCHIATRY RESEARCH
LA English
DT Article
DE Chronic inpatients; Metabolic syndrome; Rehabilitation; Schizophrenia
ID PSYCHIATRIC-INPATIENTS; HIGH PREVALENCE; WORK STRESS; RISK; OBESITY;
   DISORDERS; SEVERITY; MTHFR
AB The correlation between different rehabilitation programs and the prevalence of metabolic syndrome in people with schizophrenia is unclear. We tested the association in chronic inpatients with schizophrenia of a psychiatric hospital in Taiwan. Patients with schizophrenia and age from 20 to 65 years old were included. The criteria of metabolic syndrome were according to the adapted Adult Treatment Protocol for Asians. According to different types of rehabilitations, patients were divided into work group, occupational therapy group and daily activities group. A total of 359 chronic inpatients with schizophrenia were recruited. Participants had a mean age of 45.9 years and the prevalence of metabolic syndrome was 37.3%. There was a significantly higher prevalence of metabolic syndrome in the work group than in the daily activity group (adjusted odds ratio (aOR) = 1.91, 95% CI = 1.019-3.564, p < 0.05) after adjusted related confounders. Other factors associated with higher prevalence of metabolic syndrome included old age, female gender, low psychotic symptoms severity and clozapine user. This study identified a high prevalence of metabolic syndrome in chronic inpatients with schizophrenia especially in patients with good occupational function. Further investigation of the relationship between the occupational function and metabolic syndrome is necessary for chronic inpatients with schizophrenia.
C1 [Lin, Yi-Chun; Lai, Chien-Liang; Chan, Hung-Yu] Minist Hlth & Welf, Taoyuan Psychiat Ctr, Dept Gen Psychiat, Taoyuan, Taiwan.
   [Chan, Hung-Yu] Natl Taiwan Univ, Natl Taiwan Univ Hosp, Dept Psychiat, Taipei, Taiwan.
   [Chan, Hung-Yu] Natl Taiwan Univ, Coll Med, Taipei, Taiwan.
C3 National Taiwan University; National Taiwan University Hospital;
   National Taiwan University
RP Chan, HY (corresponding author), Minist Hlth & Welf, Taoyuan Psychiat Ctr, 71 Long Show St, Taoyuan 33058, Taiwan.
EM jan30@seed.net.tw
FU Taoyuan Psychiatric Center, Ministry of Health and Welfare of Taiwan
   [TYPC201104]
FX This study was supported by a grant from the Taoyuan Psychiatric Center,
   Ministry of Health and Welfare of Taiwan (TYPC201104). The funding body
   played no role in study design, analysis or interpretation of data in
   this paper.
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NR 39
TC 5
Z9 5
U1 0
U2 10
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0165-1781
J9 PSYCHIAT RES
JI Psychiatry Res.
PD FEB
PY 2018
VL 260
BP 227
EP 232
DI 10.1016/j.psychres.2017.11.081
PG 6
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA FV8RU
UT WOS:000424855300034
PM 29216485
DA 2025-06-11
ER

PT J
AU Cannizzaro, L
   Rossoni, G
   Savi, F
   Altomare, A
   Marinello, C
   Saethang, T
   Carini, M
   Payne, DM
   Pisitkun, T
   Aldini, G
   Leelahavanichkul, A
AF Cannizzaro, Luca
   Rossoni, Giuseppe
   Savi, Federica
   Altomare, Alessandra
   Marinello, Cristina
   Saethang, Thammakorn
   Carini, Marina
   Payne, D. Michael
   Pisitkun, Trairak
   Aldini, Giancarlo
   Leelahavanichkul, Asada
TI Regulatory landscape of AGE-RAGE-oxidative stress axis and its
   modulation by PPAR. activation in high fructose diet-induced metabolic
   syndrome
SO NUTRITION & METABOLISM
LA English
DT Article
DE AGE-RAGE-oxidative stress axis; Fructose; HNE; Metabolic syndrome; PPAR
   gamma; Rosiglitazone
ID GLYCATION END-PRODUCTS; RECEPTOR-GAMMA; ROSIGLITAZONE; LIVER; CELLS;
   RATS; PIOGLITAZONE; SYSTEM; METHYLGLYOXAL; INFLAMMATION
AB Background: The AGE-RAGE-oxidative stress (AROS) axis is involved in the onset and progression of metabolic syndrome induced by a high-fructose diet (HFD). PPAR. activation is known to modulate metabolic syndrome; however a systems-level investigation looking at the protective effects of PPAR. activation as related to the AROS axis has not been performed. The aim of this work is to simultaneously characterize multiple molecular parameters within the AROS axis, using samples taken from different body fluids and tissues of a rat model of HFD-induced metabolic syndrome, in the presence or absence of a PPAR. agonist, Rosiglitazone (RGZ).
   Methods: Rats were fed with 60% HFD for the first half of the treatment duration (21 days) then continued with either HFD alone or HFD plus RGZ for the second half.
   Results: Rats receiving HFD alone showed metabolic syndrome manifestations including hypertension, dyslipidemia, increased glucose levels and insulin resistance, as well as abnormal kidney and inflammatory parameters. Systolic blood pressure, plasma triglyceride and glucose levels, plasma creatinine, and albuminuria were significantly improved in the presence of RGZ. The following molecular parameters of the AROS axis were significantly upregulated in our rat model: carboxymethyl lysine (CML) in urine and liver; carboxyethyl lysine (CEL) in urine; advanced glycation end products (AGEs) in plasma; receptor for advanced glycation end products (RAGE) in liver and kidney; advanced oxidation protein products (AOPP) in plasma; and 4-hydroxynonenal (HNE) in plasma, liver, and kidney. Conversely, with RGZ administration, the upregulation of AOPP and AGEs in plasma, CML and CEL in urine, RAGE in liver as well as HNE in plasma and liver was significantly counteracted/prevented.
   Conclusions: Our data demonstrate (i) the systems-level regulatory landscape of HFD-induced metabolic syndrome involving multiple molecular parameters, including HNE, AGEs and their receptor RAGE, and (ii) attenuation of metabolic syndrome by PPAR. modulation.
C1 [Cannizzaro, Luca; Saethang, Thammakorn; Payne, D. Michael; Pisitkun, Trairak] Chulalongkorn Univ, Syst Biol Ctr, Fac Med, Bangkok 10330, Thailand.
   [Cannizzaro, Luca; Altomare, Alessandra; Marinello, Cristina; Carini, Marina; Aldini, Giancarlo] Univ Milan, Dept Pharmaceut Sci, Via Mangiagalli 25, I-20133 Milan, Italy.
   [Rossoni, Giuseppe] Univ Milan, Dept Med Biotechnol & Translat Med, Via Vanvitelli 32, I-20129 Milan, Italy.
   [Savi, Federica] ASST Santi Paolo & Carlo, Pathol Anat Unit, UOC Anat Patol, Via Rudini 8, I-20142 Milan, Italy.
   [Leelahavanichkul, Asada] Chulalongkorn Univ, Dept Microbiol, Fac Med, Ctr Excellence Immunol & Immune Mediated Dis, Bangkok 10330, Thailand.
C3 Chulalongkorn University; University of Milan; University of Milan;
   Chulalongkorn University
RP Aldini, G (corresponding author), Univ Milan, Dept Pharmaceut Sci, Via Mangiagalli 25, I-20133 Milan, Italy.; Leelahavanichkul, A (corresponding author), Chulalongkorn Univ, Dept Microbiol, Fac Med, Ctr Excellence Immunol & Immune Mediated Dis, Bangkok 10330, Thailand.
EM giancarlo.aldini@unimi.it; asada.l@chula.ac.th
RI aldini, giancarlo/C-3533-2013; Saethang, Thammakorn/AAT-6853-2021
OI Altomare, Alessandra Anna/0000-0002-9906-6098; MARINELLO,
   CRISTINA/0000-0002-8151-9415
FU Chulalongkorn University Ratchadaphiseksomphot Fund; Chulalongkorn
   Academic Advancement into Its 2nd Century Project
FX Luca Cannizzaro is a recipient of the Post-Doctoral Scholarship,
   Chulalongkorn University Ratchadaphiseksomphot Fund and was also
   supported by the Chulalongkorn Academic Advancement into Its 2nd Century
   Project.
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NR 51
TC 30
Z9 33
U1 0
U2 11
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1743-7075
J9 NUTR METAB
JI Nutr. Metab.
PD JAN 13
PY 2017
VL 14
AR 5
DI 10.1186/s12986-016-0149-z
PG 13
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA EI1QI
UT WOS:000392252600001
PM 28101123
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Seo, JA
   Song, SW
   Han, K
   Lee, KJ
   Kim, HN
AF Seo, Jin-A
   Song, Sang-Wook
   Han, Kyungdo
   Lee, Kyung-Jin
   Kim, Ha-Na
TI The Associations between Serum Zinc Levels and Metabolic Syndrome in the
   Korean Population: Findings from the 2010 Korean National Health and
   Nutrition Examination Survey
SO PLOS ONE
LA English
DT Article
ID INSULIN-RESISTANCE; OXIDATIVE STRESS; SUPPLEMENTATION; GLUCOSE;
   CHOLESTEROL; PREVALENCE; MECHANISM; TRANSPORT; LIVER
AB The prevalence of metabolic syndrome has been increasing rapidly worldwide. The functions of zinc may have a potential association with metabolic syndrome, but such associations have not been investigated extensively. Therefore, we examined the relationship between serum zinc levels and metabolic syndrome or metabolic risk factors among South Korean adults >= 20 years of age. The analysis used data from the Korean National Health and Nutrition Examination Survey, a cross-sectional survey of Korean civilians, conducted from January to December 2010. A total of 1,926 participants were analyzed in this study. Serum zinc levels in men were negatively associated with elevated fasting glucose (adjusted odds ratio [aOR], 0.58; 95% confidence interval [CI], 0.36-0.93) and positively associated with elevated triglycerides (aOR, 1.47; 95% CI, 1.01-2.13). A difference in serum zinc levels was detected in women, depending on the number of metabolic syndrome components (p = 0.002). Furthermore, serum zinc levels showed a decreasing trend with increasing numbers of metabolic syndrome components in women with metabolic syndrome. These findings suggest that serum zinc levels might be associated with metabolic syndrome or metabolic risk factors. Further gender-specific studies are needed to evaluate the effect of dietary or supplemental zinc intake on metabolic syndrome.
C1 [Seo, Jin-A; Song, Sang-Wook; Lee, Kyung-Jin; Kim, Ha-Na] Catholic Univ Korea, Coll Med, St Vincents Hosp, Dept Family Med, Seoul, South Korea.
   [Han, Kyungdo] Catholic Univ Korea, Coll Med, Dept Biostat, Seoul, South Korea.
   [Han, Kyungdo] Catholic Univ Korea, Coll Med, Dept Prevent Med, Seoul, South Korea.
C3 Catholic University of Korea; Catholic University of Korea; Catholic
   University of Korea
RP Kim, HN (corresponding author), Catholic Univ Korea, Coll Med, St Vincents Hosp, Dept Family Med, Seoul, South Korea.
EM onef01@catholic.ac.kr
RI Han, Kyungdo/JKH-7628-2023
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NR 48
TC 69
Z9 71
U1 0
U2 3
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD AUG 25
PY 2014
VL 9
IS 8
AR e105990
DI 10.1371/journal.pone.0105990
PG 10
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA AN9TR
UT WOS:000340952200101
PM 25153887
OA Green Submitted, gold, Green Published
DA 2025-06-11
ER

PT J
AU Chakraborty, S
   Verma, A
   Garg, R
   Singh, J
   Verma, H
AF Chakraborty, Snigdha
   Verma, Anjali
   Garg, Rajeev
   Singh, Jyoti
   Verma, Hitesh
TI Cardiometabolic Risk Factors Associated With Type 2 Diabetes Mellitus: A
   Mechanistic Insight
SO CLINICAL MEDICINE INSIGHTS-ENDOCRINOLOGY AND DIABETES
LA English
DT Review
DE Type 2 diabetic mellitus (T2DM); cardiometabolic risk factors; obesity;
   dyslipidemia; hypertension; diabetic nephropathy; cardiovascular
   diseases; mortality
ID LEFT-VENTRICULAR HYPERTROPHY; INSULIN-RESISTANCE;
   CARDIOVASCULAR-DISEASE; OXIDATIVE STRESS; ENDOTHELIAL DYSFUNCTION;
   VASCULAR COMPLICATIONS; ATRIAL-FIBRILLATION; ARTERIAL STIFFNESS;
   METABOLIC SYNDROME; ISCHEMIC-STROKE
AB A complex metabolic condition referred to as Type 2 diabetes mellitus (T2DM) is characterized by insulin resistance (IR) and decreased insulin production. Obesity, dyslipidemia, hypertension, and chronic inflammation are just a few of the cardiometabolic illnesses that people with T2DM are more likely to acquire and results in cardiovascular issues. It is essential to comprehend the mechanistic insights into these risk variables in order to prevent and manage cardiovascular problems in T2DM effectively. Impaired glycemic control leads to upregulation of De novo lipogenesis (DNL), promote hepatic triglyceride (TG) synthesis, worsening dyslipidemia that is accompanied by low levels of high density lipoprotein cholesterol (HDL-C) and high amounts of small, dense low-density lipoprotein cholesterol (LDL-C) further developing atherosclerosis. By causing endothelial dysfunction, oxidative stress, and chronic inflammation, chronic hyperglycemia worsens already existing cardiometabolic risk factors. Vasoconstriction, inflammation, and platelet aggregation are caused by endothelial dysfunction, which is characterized by decreased nitric oxide production, increased release of vasoconstrictors, proinflammatory cytokines, and adhesion molecules. The loop of IR and endothelial dysfunction is sustained by chronic inflammation fueled by inflammatory mediators produced in adipose tissue. Infiltrating inflammatory cells exacerbate inflammation and the development of plaque in the artery wall. In addition, the combination of chronic inflammation, dyslipidemia, and IR contributes to the emergence of hypertension, a prevalent comorbidity in T2DM. The ability to target therapies and management techniques is made possible by improvements in our knowledge of these mechanistic insights. Aim of present review is to enhance our current understanding of the mechanistic insights into the cardiometabolic risk factors related to T2DM provides important details into the interaction of pathophysiological processes resulting in cardiovascular problems. Understanding these pathways will enable us to create efficient plans for the prevention, detection, and treatment of cardiovascular problems in T2DM patients, ultimately leading to better overall health outcomes.
   Understanding the factors that increase the risk of type 2 diabetes: Exploring how the body worksType 2 diabetes mellitus (T2DM) is a complex condition where the body struggles to use insulin properly and doesn't produce enough of it. This often leads to other health issues like obesity, high cholesterol, high blood pressure, and chronic inflammation. These problems increase the risk of heart and blood vessel diseases in people with T2DM. To tackle these issues effectively, it's crucial to understand the underlying mechanisms. When blood sugar levels are not controlled, the body starts making more fat and storing it in the liver, leading to high triglycerides and low levels of good cholesterol. This process can block arteries, causing heart problems. High blood sugar also damages blood vessel linings, making them inflamed and less functional. This inflammation, combined with other factors like high cholesterol and insulin resistance, can lead to high blood pressure. Chronic inflammation, where the body's defense system stays active for too long, worsens these problems. In T2DM, inflammation occurs in fat tissues, making the situation even worse. Inflammatory cells infiltrate blood vessel walls, promoting plaque buildup and further worsening heart issues. Understanding these processes helps us develop better strategies to prevent, detect, and treat heart problems in people with T2DM. By targeting these mechanisms, doctors can create more effective plans to improve the overall health of individuals with diabetes and reduce the risk of cardiovascular diseases.
C1 [Chakraborty, Snigdha; Verma, Hitesh] Overseas HealthCare Pvt Ltd, Overseas R&D Ctr, Phillaur, Punjab, India.
   [Verma, Anjali; Singh, Jyoti] Lovely Profess Univ, Sch Agr, Dept Food Technol & Nutr, Phagwara, Punjab, India.
   [Garg, Rajeev; Verma, Hitesh] IKG Punjab Tech Univ, Kapurthala, India.
   [Garg, Rajeev; Verma, Hitesh] Amar Shaheed Baba Ajit Singh Jujhar Singh Mem Coll, Ropar, Punjab, India.
   [Garg, Rajeev] Guru Nanak Inst Pharm, Hoshiarpur, Punjab, India.
   [Verma, Hitesh] Biofern Life Sci Pvt Ltd, Harjenahalli, Karnataka, India.
   [Verma, Hitesh] Biofern Life Sci Pvt Ltd, 168-P5 Vemgal Ind Area, Harjenahalli, Karnataka, India.
C3 Lovely Professional University; I. K. Gujral Punjab Technical University
RP Verma, H (corresponding author), Biofern Life Sci Pvt Ltd, 168-P5 Vemgal Ind Area, Harjenahalli, Karnataka, India.
EM hitesh.vermaphd@gmail.com
RI singh, jyoti/AAJ-9853-2021
OI chakraborty, snigdha/0009-0000-0615-771X
FU Overseas Health Care Pvt. Ltd
FX Authors would like to thank Overseas Health Care Pvt. Ltd, Phillaur for
   providing necessary facilities for completion of this work.
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NR 173
TC 25
Z9 25
U1 0
U2 5
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1179-5514
J9 CLIN MED INSIGHTS-EN
JI Clin. Med. Insights-Endocrinol. Diabetes
PY 2023
VL 16
AR 11795514231220780
DI 10.1177/11795514231220780
PG 18
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA DV3H8
UT WOS:001134813400001
PM 38148756
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Li, AX
   Zheng, NN
   Ding, XD
AF Li, Aoxue
   Zheng, Ningning
   Ding, Xudong
TI Mitochondrial abnormalities: a hub in metabolic syndrome-related cardiac
   dysfunction caused by oxidative stress
SO HEART FAILURE REVIEWS
LA English
DT Article
DE Oxidative stress; Mitochondria; Reactive oxygen species; Metabolic
   syndrome; Cardiac dysfunction
ID ISCHEMIA/REPERFUSION INJURY; HYDROGEN-PEROXIDE; DNA DAMAGE; HEART;
   APOPTOSIS; CONTRIBUTES; ACCUMULATION; RESPIRATION; ACTIVATION;
   MECHANISMS
AB Metabolic syndrome (MetS) refers to a group of cardiovascular risk elements comprising insulin resistance, obesity, dyslipidemia, increased glucose intolerance, and increased blood pressure. Individually, all the MetS components can lead to cardiac dysfunction, while their combination generates additional risks of morbidity and mortality. Growing evidence suggests that oxidative stress, a dominant event in cellular damage and impairment, plays an indispensable role in cardiac dysfunction in MetS. Oxidative stress can not only disrupt mitochondrial activity through inducing oxidative damage to mitochondrial DNA, RNA, lipids, and proteins but can also impair cardiomyocyte contractile function via mitochondria-related oxidative modifications of proteins central to excitation-contraction coupling. Furthermore, excessive reactive oxygen species (ROS) generation can lead to the activation of several mitochondria apoptotic signaling pathways, release of cytochrome c, and eventual induction of myocardial apoptosis. This review will focus on such processes of mitochondrial abnormalities in oxidative stress induced cardiac dysfunction in MetS.
C1 [Li, Aoxue] China Med Univ, China Med Univ Queens Univ Belfast Joint Coll, Dept Pharmaceut Biotechnol, Shenyang, Liaoning, Peoples R China.
   [Li, Aoxue] Covance Pharmaceut Res & Dev Beijing Co Ltd, Beijing, Peoples R China.
   [Zheng, Ningning] China Med Univ, Coll Basic Med Sci, Dept Pathophysiol, Shenyang, Liaoning, Peoples R China.
   [Ding, Xudong] China Med Univ, Shengjing Hosp, Dept Anesthesiol, Shenyang, Liaoning, Peoples R China.
C3 China Medical University; China Medical University; China Medical
   University
RP Ding, XD (corresponding author), China Med Univ, Shengjing Hosp, Dept Anesthesiol, Shenyang, Liaoning, Peoples R China.
EM dingxd@sj-hospital.org
RI Zheng, Ningning/KHU-0389-2024
OI Li, Aoxue/0000-0003-1651-114X
FU National Natural Science Foundation of China [81800763]; Natural Science
   Foundation of Liaoning Province of China [20180551076]
FX The work was supported by the National Natural Science Foundation of
   China (FUND#81800763) and the Natural Science Foundation of Liaoning
   Province of China (FUND#20180551076).
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NR 51
TC 44
Z9 50
U1 3
U2 24
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1382-4147
EI 1573-7322
J9 HEART FAIL REV
JI Heart Fail. Rev.
PD JUL
PY 2022
VL 27
IS 4
BP 1387
EP 1394
DI 10.1007/s10741-021-10109-6
EA MAY 2021
PG 8
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 2D0AG
UT WOS:000647347100001
PM 33950478
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Jain, N
   Naseem, I
   Ahmad, J
AF Jain, Nishtha
   Naseem, Imrana
   Ahmad, Jamal
TI Evaluation of DNA damage and metabolic syndrome parameters in diabetic
   rabbits supplemented with antioxidants
SO FUNDAMENTAL & CLINICAL PHARMACOLOGY
LA English
DT Article
DE comet assay; DNA damage; metabolic syndrome; serum paraoxonase-1; Small
   dense low density lipoprotein
ID OXIDATIVE STRESS; ALPHA-TOCOPHEROL; CARDIOVASCULAR-DISEASE; HEALTH;
   RISK; LDL; STREPTOZOTOCIN; PEROXIDATION; ASSOCIATION; PREVENTION
AB The aim of the present study is to evaluate the extent of DNA damage in diabetes and metabolic syndrome and to assess the variations after supplementation with antioxidants. We used comet assay to measure DNA damage in freshly isolated lymphocytes from a total of 12 rabbits, distributed into four experimental groups (n = 3 rabbits per group): non-diabetic (control, G1), diabetic (G2), diabetic supplemented with vitamin C (G3), and diabetic supplemented with vitamin E (G4). Also their serum was isolated for estimation of parameters that contribute to metabolic syndrome. Malondialdehyde (MDA), the marker of oxidative stress was also assessed. Mean values of DNA damage (tail length, expressed as mu m), lipid peroxidation and concentration of blood glucose, MDA, C-reactive protein, and triglycerides were higher in G2; whereas the mean values of concentration of high-density lipoprotein, serum paraoxonase-1 activity and small dense low-density lipoprotein oxidation time were reduced in G2 followed by G3, G4, and G1. A significant positive correlation was observed between the DNA damage and elevated parameters of metabolic syndrome (r = 0.66, 0.96, 0.89, 0.75, 0.88, 0.92, 0.99, P < 0.05) and a significant negative correlation (r = -0.91, -0.75, -0.98, P < 0.05) was found between the DNA damage and declined parameters of metabolic syndrome. These data indicate that the extent of DNA damage is more in diabetic rabbits as compared to the non-diabetic or antioxidant supplemented group. Abnormal metabolic parameters and their correlation with DNA damage, suggest the risk of development of metabolic syndrome in diabetic group but a possibility of repression by antioxidants because of their ability to counteract oxidative stress.
C1 [Jain, Nishtha; Naseem, Imrana] Aligarh Muslim Univ, Fac Life Sci, Dept Biochem, Aligarh 202002, Uttar Pradesh, India.
   [Ahmad, Jamal] Aligarh Muslim Univ, Dept Med, JN Med Coll, Aligarh 202002, Uttar Pradesh, India.
C3 Aligarh Muslim University; Aligarh Muslim University
RP Naseem, I (corresponding author), Aligarh Muslim Univ, Fac Life Sci, Dept Biochem, Aligarh 202002, Uttar Pradesh, India.
EM imrana.naseem@hotmail.com
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NR 40
TC 17
Z9 17
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0767-3981
EI 1472-8206
J9 FUND CLIN PHARMACOL
JI Fundam. Clin. Pharmacol.
PD APR
PY 2009
VL 23
IS 2
BP 197
EP 205
DI 10.1111/j.1472-8206.2009.00666.x
PG 9
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 421QK
UT WOS:000264373200006
PM 19645814
OA Bronze
DA 2025-06-11
ER

PT J
AU Happell, B
   Platania-Phung, C
   Scott, D
   Nankivell, J
AF Happell, Brenda
   Platania-Phung, Chris
   Scott, David
   Nankivell, Janette
TI Communication With Colleagues: Frequency of Collaboration Regarding
   Physical Health of Consumers With Mental Illness
SO PERSPECTIVES IN PSYCHIATRIC CARE
LA English
DT Article
DE Severe mental illness; physical health care; teamwork; chronic disease
   management; collaborative care
ID METABOLIC SYNDROME; OLDER-ADULTS; CARE; PEOPLE; SCHIZOPHRENIA; NURSES;
   MORTALITY; PREVALENCE; ATTITUDES; BARRIERS
AB PurposeTo identify how frequently nurses in mental health services communicate about physical health of consumers with other healthcare professionals, and whether such collaboration is associated with physical care actions with consumers.
   Design and MethodsAn online national Australian survey of nurses in mental health services.
   FindingsNurses discuss physical health frequently with general practitioners, psychiatrists, and case managers, and less frequently with occupational therapists, social workers, and nurse practitioners. Interprofessional attention was positively associated with direct physical health care such as clinical screening and health education.
   Practice ImplicationsInterprofessional communication may support nurses in direct physical healthcare actions with consumers. Increasing collaborations with nurse practitioners, social workers, and occupational therapists need to be explored as part of clinical teamwork development.
C1 [Happell, Brenda; Platania-Phung, Chris; Scott, David] Cent Queensland Univ, Inst Hlth & Social Sci Res, Ctr Mental Hlth Nursing Innovat, Sch Nursing & Midwifery, Rockhampton, Qld 4702, Australia.
   [Nankivell, Janette] Cent Queensland Univ, Inst Hlth & Social Sci Res, Sch Nursing & Midwifery, Rockhampton, Qld 4702, Australia.
C3 Central Queensland University; Central Queensland University
RP Happell, B (corresponding author), Cent Queensland Univ, Inst Hlth & Social Sci Res, Ctr Mental Hlth Nursing Innovat, Sch Nursing & Midwifery, Rockhampton, Qld 4702, Australia.
EM b.happell@cqu.edu.au
RI Scott, David/AAE-5031-2021; Happell, Brenda/HSI-0570-2023
OI Scott, David/0000-0001-5226-1972; Happell, Brenda/0000-0002-7293-6583
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NR 51
TC 18
Z9 19
U1 0
U2 17
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0031-5990
EI 1744-6163
J9 PERSPECT PSYCHIATR C
JI Perspect. Psychiatr. Care
PD JAN
PY 2014
VL 50
IS 1
BP 33
EP 43
DI 10.1111/ppc.12021
PG 11
WC Nursing; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Psychiatry
GA 284HD
UT WOS:000329305800006
PM 24387613
DA 2025-06-11
ER

PT J
AU Bungau, AF
   Radu, AF
   Bungau, SG
   Vesa, CM
   Tit, DM
   Endres, LM
AF Bungau, Alexa Florina
   Radu, Andrei Flavius
   Bungau, Simona Gabriela
   Vesa, Cosmin Mihai
   Tit, Delia Mirela
   Endres, Laura Maria
TI Oxidative stress and metabolic syndrome in acne vulgaris: Pathogenetic
   connections and potential role of dietary supplements and phytochemicals
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Review
DE Oxidative stress; Metabolic syndrome; Acne vulgaris; Supplements;
   Phytochemicals
ID PROLIFERATOR-ACTIVATED RECEPTORS; POLYCYSTIC-OVARY-SYNDROME; BODY-MASS
   INDEX; LIPID-PEROXIDATION; PEROXISOME PROLIFERATOR; INSULIN-RESISTANCE;
   ANTIOXIDANT STATUS; HYDROGEN-PEROXIDE; RISK-FACTOR;
   BIOLOGICAL-ACTIVITIES
AB Acne vulgaris is a highly prevalent skin condition caused by androgen-induced elevated sebum secretion, abnormal keratinization, bacterial colonization, and inflammation. Current research indicates a link between acne vulgaris and the metabolic syndrome, a group of disorders that includes obesity, insulin resistance, hypertension, and dyslipidemia. This link is thought to be modulated by excessive concentrations of oxidative stress markers and chronic inflammation, which are included in the pathophysiological mechanisms shared by both conditions. Excessive generation of reactive oxygen species damages cellular components and initiates an inflammatory response, hence promoting the development of both disorders. The current narrative review focuses on the molecular implications of inflammatory, hormonal, and environmental factors in the acne-metabolic syndrome correlation. Furthermore, it outlines the current state of knowledge related to the phyto-therapeutic approach to these conditions as an adjuvant strategy to allopathic treatment, but future multicenter and larger-scale research studies are needed establish new algorithms to be included in the future management of patients with these conditions.
C1 [Bungau, Alexa Florina; Radu, Andrei Flavius; Bungau, Simona Gabriela; Vesa, Cosmin Mihai; Tit, Delia Mirela] Univ Oradea, Doctoral Sch Biol & Biomed Sci, Oradea 410087, Romania.
   [Radu, Andrei Flavius] Univ Oradea, Fac Med & Pharm, Dept Preclin Disciplines, Oradea 410073, Romania.
   [Bungau, Simona Gabriela; Tit, Delia Mirela] Univ Oradea, Fac Med & Pharm, Dept Pharm, Oradea 410028, Romania.
   [Endres, Laura Maria] Univ Oradea, Fac Med & Pharm, Dept Psychoneurosci & Recovery, Oradea 410073, Romania.
C3 University of Oradea; University of Oradea; University of Oradea;
   University of Oradea
RP Radu, AF; Bungau, SG (corresponding author), Univ Oradea, Doctoral Sch Biol & Biomed Sci, Oradea 410087, Romania.; Radu, AF (corresponding author), Univ Oradea, Fac Med & Pharm, Dept Preclin Disciplines, Oradea 410073, Romania.; Bungau, SG (corresponding author), Univ Oradea, Fac Med & Pharm, Dept Pharm, Oradea 410028, Romania.
EM andreiflavius.radu@gmail.com; simonabungau@gmail.com
RI Bungau, Alexa/AGY-4752-2022; Tit, Delia/AAT-5032-2020; Endres,
   Laura/AAY-5100-2020; Radu, Andrei-Flavius/AAD-3129-2022; Bungau, Simona
   Gabriela/C-1831-2015; Mihai, Vesa/AAE-5495-2019
OI Cosmin Mihai, Vesa/0000-0001-5071-9601
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NR 206
TC 25
Z9 25
U1 6
U2 31
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD AUG
PY 2023
VL 164
AR 115003
DI 10.1016/j.biopha.2023.115003
EA JUN 2023
PG 15
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA L6LK5
UT WOS:001024356000001
PM 37315434
OA gold
DA 2025-06-11
ER

PT J
AU Cheong, JDLK
   Croft, KD
   Henry, PD
   Matthews, V
   Hodgson, JM
   Ward, NC
AF Cheong, J. D. Li Kwok
   Croft, K. D.
   Henry, P. D.
   Matthews, V.
   Hodgson, J. M.
   Ward, N. C.
TI Green coffee polyphenols do not attenuate features of the metabolic
   syndrome and improve endothelial function in mice fed a high fat diet
SO ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
LA English
DT Article
DE Chlorogenic acid; Atherosclerosis; Metabolic syndrome; Endothelial
   dysfunction; Coffee
ID E-KNOCKOUT MICE; CHLOROGENIC ACID; OXIDATIVE STRESS; PHENOLIC-COMPOUNDS;
   TEA CONSUMPTION; DYSFUNCTION; OBESITY; PLASMA; ATHEROSCLEROSIS;
   CARBOHYDRATE
AB We have investigated the effects of the major polyphenol in coffee, chlorogenic acid (CGA), on obesity, glucose intolerance, insulin resistance, systemic oxidative stress and endothelial dysfunction in a mouse model of the metabolic syndrome. Thirty C57BL6 mice were randomly divided into (n = 10/group) (i) normal diet (ND), (ii) high fat diet (HFD), or (iii) high fat diet supplemented with 0.5% w/w green coffee bean extract (GCE) rich in chlorogenic acid (HFD + GCE). The high fat diet consisted of 28% fat and all animals were maintained on their diets for 12 weeks. The mice fed a HFD and HFD + GCE displayed symptoms of the metabolic syndrome compared to their normal fed counterparts, although no endothelial dysfunction was detected in the abdominal aortas after 12 weeks. GCE did not attenuate HFD-induced obesity, glucose intolerance, insulin resistance or systemic oxidative stress. Furthermore, GCE did not protect against ex vivo oxidant (hypochlorous acid)-induced endothelial dysfunction. (C) 2014 Elsevier Inc. All rights reserved.
C1 [Cheong, J. D. Li Kwok; Croft, K. D.; Henry, P. D.; Hodgson, J. M.; Ward, N. C.] Univ Western Australia, Sch Med & Pharmacol, Perth, WA 6847, Australia.
   [Matthews, V.] Harry Perkins Inst Med Res, UWA Ctr Med Res, Lab Metab Dysfunct, Perth, WA, Australia.
C3 University of Western Australia; Harry Perkins Institute of Medical
   Research
RP Ward, NC (corresponding author), Univ Western Australia, Sch Med & Pharmacol, GPO Box X2213, Perth, WA 6847, Australia.
EM natalie.ward@uwa.edu.au
RI Croft, Kevin/C-4675-2013
OI Henry, Peter/0000-0002-8213-0508; Croft, Kevin/0000-0003-1596-4913;
   Ward, Natalie/0000-0002-6042-437X
FU Raine Medical Research Foundation; MRF/UWA Postdoctoral Fellowship;
   NHMRC
FX This study was supported by a Raine Medical Research Foundation Priming
   Grant. The authors acknowledge the A. Mubarak, A. Indrawan and Y. Shen
   for their valuable laboratory assistance. N.C. Ward acknowledges the
   support of a MRF/UWA Postdoctoral Fellowship. J.M. Hodgson acknowledges
   the support of a NHMRC Senior Research Fellowship. V. Matthews
   acknowledges the support of a NHMRC Career Development Fellowship.
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NR 39
TC 30
Z9 31
U1 0
U2 60
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0003-9861
EI 1096-0384
J9 ARCH BIOCHEM BIOPHYS
JI Arch. Biochem. Biophys.
PD OCT 1
PY 2014
VL 559
SI SI
BP 46
EP 52
DI 10.1016/j.abb.2014.02.005
PG 7
WC Biochemistry & Molecular Biology; Biophysics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics
GA AO1LH
UT WOS:000341073100008
PM 24583266
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Tain, YL
   Hsu, CN
   Chan, JYH
AF Tain, You-Lin
   Hsu, Chien-Ning
   Chan, Julie Y. H.
TI PPARs Link Early Life Nutritional Insults to Later Programmed
   Hypertension and Metabolic Syndrome
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE developmental programming; hypertension; kidney; metabolic syndrome;
   nutrient sensing; peroxisome proliferator-activated receptor
ID PROLIFERATOR-ACTIVATED RECEPTORS; MATERNAL CITRULLINE SUPPLEMENTATION;
   BLOOD-PRESSURE; PRENATAL DEXAMETHASONE; OXIDATIVE STRESS; NITRIC-OXIDE;
   ASYMMETRIC DIMETHYLARGININE; GAMMA; ALPHA; KIDNEY
AB Hypertension is an important component of metabolic syndrome. Adulthood hypertension and metabolic syndrome can be programmed in response to nutritional insults in early life. Peroxisome proliferator-activated receptors (PPARs) serve as a nutrient-sensing signaling linking nutritional programming to hypertension and metabolic syndrome. All three members of PPARs, PPAR alpha, PPAR beta/delta, and PPAR gamma, are expressed in the kidney and involved in blood pressure control. This review provides an overview of potential clinical applications of targeting on the PPARs in the kidney to prevent programmed hypertension and metabolic syndrome, with an emphasis on the following areas: mechanistic insights to interpret programmed hypertension; the link between the PPARs, nutritional insults, and programmed hypertension and metabolic syndrome; the impact of PPAR signaling pathway in a maternal high-fructose model; and current experimental studies on early intervention by PPAR modulators to prevent programmed hypertension and metabolic syndrome. Animal studies employing a reprogramming strategy via targeting PPARs to prevent hypertension have demonstrated interesting results. It is critical that the observed effects on developmental reprogramming in animal models are replicated in human studies, to halt the globally-growing epidemic of metabolic syndrome-related diseases.
C1 [Tain, You-Lin] Chang Gung Univ, Coll Med, Kaohsiung Chang Gung Mem Hosp, Dept Pediat, Kaohsiung 833, Taiwan.
   [Tain, You-Lin; Chan, Julie Y. H.] Chang Gung Univ, Coll Med, Kaohsiung Chang Gung Mem Hosp, Inst Translat Res Biomed, Kaohsiung 833, Taiwan.
   [Hsu, Chien-Ning] Kaohsiung Chang Gung Mem Hosp, Dept Pharm, Kaohsiung 833, Taiwan.
   [Hsu, Chien-Ning] Kaohsiung Med Univ, Sch Pharm, Kaohsiung 807, Taiwan.
C3 Chang Gung University; Chang Gung Memorial Hospital; Chang Gung
   University; Chang Gung Memorial Hospital; Chang Gung Memorial Hospital;
   Kaohsiung Medical University
RP Tain, YL (corresponding author), Chang Gung Univ, Coll Med, Kaohsiung Chang Gung Mem Hosp, Dept Pediat, Kaohsiung 833, Taiwan.; Tain, YL (corresponding author), Chang Gung Univ, Coll Med, Kaohsiung Chang Gung Mem Hosp, Inst Translat Res Biomed, Kaohsiung 833, Taiwan.
EM tainyl@cgmh.org.tw; cnhsu@cgmh.org.tw; jchan@cgmh.org.tw
RI Chan, Julie/X-5253-2019; Tain, You-Lin/H-2827-2019; Hsu,
   Chien-Ning/GLS-4014-2022
OI Tain, You-Lin/0000-0002-7059-6407; Hsu, Chien-Ning/0000-0001-7470-528X
FU Ministry of Science and Technology, Taiwan [MOST
   104-2314-B-182-056-MY3]; Chang Gung Memorial Hospital, Kaohsiung, Taiwan
   [CMRPG8C0043, CMRPG8D0202]
FX This work was supported by the Grant MOST 104-2314-B-182-056-MY3 from
   Ministry of Science and Technology, Taiwan, and the Grant CMRPG8C0043
   and CMRPG8D0202 from Chang Gung Memorial Hospital, Kaohsiung, Taiwan.
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NR 61
TC 49
Z9 50
U1 3
U2 16
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD JAN
PY 2016
VL 17
IS 1
AR 20
DI 10.3390/ijms17010020
PG 11
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA DK0DW
UT WOS:000374583800020
PM 26712739
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Mahalingaiah, S
   Diamanti-Kandarakis, E
AF Mahalingaiah, Shruthi
   Diamanti-Kandarakis, Evanthia
TI Targets to treatmetabolic syndrome in polycystic ovary syndrome
SO EXPERT OPINION ON THERAPEUTIC TARGETS
LA English
DT Review
DE group care; lifestyle modification; metabolic syndrome; polycystic ovary
   syndrome
ID CARDIOVASCULAR RISK-FACTORS; IMPAIRED GLUCOSE-TOLERANCE; LIFE-STYLE
   MODIFICATION; LOW-DENSITY-LIPOPROTEIN; GLYCATION END-PRODUCTS;
   GONADOTROPIN-RELEASING-HORMONE; FATTY LIVER-DISEASE; INSULIN-RESISTANCE;
   METABOLIC SYNDROME; OBESE WOMEN
AB Introduction: Metabolic syndrome is comprised of a combination of the following states: increased insulin resistance, dyslipidemia, cardiovascular disease, and increased abdominal obesity. Women with polycystic ovary syndrome (PCOS) have an increased risk of developing metabolic syndrome over the course of their lives. Metabolic syndrome increases risk of major cardiovascular events, morbidity, quality of life, and overall health care costs. Though metabolic syndrome in women with PCOS is an area of great concern, there is no effective individual medical therapeutic to adequately treat this issue.
   Areas Covered: This article will review key aspects of metabolic syndrome in PCOS. We will discuss classic and novel therapeutics to address metabolic syndrome in women with PCOS. We will conclude with the importance of developing strategic interventions to increase the compliance to lifestyle and dietary modification, in addition to appreciation of the emerging pharmaceutical therapeutics available.
   Expert Opinion: Innovation in lifestyle modification, including diet, exercise, with and without dedicated stress reduction techniques is the future in treatment of metabolic syndrome in PCOS. Application of novel interventions, such as group medical care, may improve future adherence to lifestyle modification recommendations, in addition to or in combination with pharmaceutical therapeutics.
C1 [Mahalingaiah, Shruthi] Boston Univ, Sch Med, Dept Obstet & Gynecol, Boston, MA 02118 USA.
   [Diamanti-Kandarakis, Evanthia] Univ Athens, Sch Med, Dept Diabet Endocrinol & Metab, Athens 11521, Greece.
C3 Boston University; Athens Medical School; National & Kapodistrian
   University of Athens
RP Diamanti-Kandarakis, E (corresponding author), Univ Athens, Sch Med, Dept Diabet Endocrinol & Metab, Athens 11521, Greece.
EM e.diamanti.kandarakis@gmail.com
OI Mahalingaiah, Shruthi/0000-0002-5527-5787
FU National Institutes of Health under the Reproductive Scientist
   Development Program [K12 HD 00849]; American College of Obstetricians
   and Gynecologists
FX S Mahalingaiah is supported by the National Institutes of Health under
   the Reproductive Scientist Development Program, grant number K12 HD
   00849, and by the American College of Obstetricians and Gynecologists
   for research on prenatal and early adult environmental exposures and
   polycystic ovary syndrome. The authors have no other relevant
   affiliations or financial involvement with any organization or entity
   with a financial interest in or financial conflict with the subject
   matter or materials discussed in the manuscript apart from those
   disclosed.
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NR 166
TC 30
Z9 43
U1 1
U2 22
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1472-8222
EI 1744-7631
J9 EXPERT OPIN THER TAR
JI Expert Opin. Ther. Targets
PY 2015
VL 19
IS 11
SI SI
BP 1561
EP 1574
DI 10.1517/14728222.2015.1101067
PG 14
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA DD4TF
UT WOS:000369914800012
PM 26488852
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Han, GM
   Meza, JL
   Soliman, GA
   Islam, KMM
   Watanabe-Galloway, S
AF Han, Guang-Ming
   Meza, Jane L.
   Soliman, Ghada A.
   Islam, K. M. Monirul
   Watanabe-Galloway, Shinobu
TI Higher levels of serum lycopene are associated with reduced mortality in
   individuals with metabolic syndrome
SO NUTRITION RESEARCH
LA English
DT Article
DE Metabolic syndrome; Mortality; Lycopene; Risk; Cox proportional hazards
   model
ID CARDIOVASCULAR-DISEASE MORTALITY; ALL-CAUSE MORTALITY; OXIDATIVE STRESS;
   ADIPOSE-TISSUE; OLDER-ADULTS; SUPPLEMENTATION; NUTRITION; METAANALYSIS;
   STROKE; RATS
AB Metabolic syndrome increases the risk of mortality. Increased oxidative stress and inflammation may play an important role in the high mortality of individuals with metabolic syndrome. Previous studies have suggested that lycopene intake might be related to the reduced oxidative stress and decreased inflammation. Using data from the National Health and Nutrition Examination Survey, we examined the hypothesis that lycopene is associated with mortality among individuals with metabolic syndrome. A total of 2499 participants 20 years and older with metabolic syndrome were divided into 3 groups based on their serum concentration of lycopene using the tertile rank method. The National Health and Nutrition Examination Survey from years 2001 to 2006 was linked to the mortality file for mortality follow-up data through December 31, 2011, to determine the mortality rate and hazard ratios (HR) for the 3 serum lycopene concentration groups. The mean survival time was significantly higher in the group with the highest serum lycopene concentration (120.6 months; 95% confidence interval [CI], 118.8-122.3) and the medium group (116.3 months; 95% CI, 115.2-117.4), compared with the group with lowest serum lycopene concentration (107.4 months; 95% CI, 106.5-108.3). After adjusting for possible confounding factors, participants in the highest (HR, 0.61; P =.0113) and in the second highest (HR, 0.67; P =.0497) serum lycopene concentration groups showed significantly lower HRs of mortality when compared with participants in the lower serum lycopene concentration. The data suggest that higher serum lycopene concentration has a significant association with the reduced risk of mortality among individuals with metabolic syndrome. (C) 2016 Elsevier Inc. All rights reserved.
C1 [Han, Guang-Ming; Islam, K. M. Monirul; Watanabe-Galloway, Shinobu] Univ Nebraska Med Ctr, Dept Epidemiol, Coll Publ Hlth, Omaha, NE 68198 USA.
   [Meza, Jane L.] Univ Nebraska Med Ctr, Dept Biostat, Coll Publ Hlth, Omaha, NE 68198 USA.
   [Soliman, Ghada A.] Univ Nebraska Med Ctr, Dept Hlth Promot Social & Behav Hlth, Coll Publ Hlth, Omaha, NE 68198 USA.
C3 University of Nebraska System; University of Nebraska Medical Center;
   University of Nebraska System; University of Nebraska Medical Center;
   University of Nebraska System; University of Nebraska Medical Center
RP Watanabe-Galloway, S (corresponding author), Univ Nebraska Med Ctr, Dept Epidemiol, Coll Publ Hlth, Omaha, NE 68198 USA.
EM swatanabe@unmc.edu
RI Han, Guang-Ming/C-6500-2017; Soliman, Ghada/U-6472-2017
OI Han, Guang-Ming/0000-0001-8901-5222; Soliman, Ghada/0000-0002-8629-6062
CR Archer E, 2015, MAYO CLIN PROC, V90, P911, DOI 10.1016/j.mayocp.2015.04.009
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   cdc, About the National Health. and Nutrition Examination Survey
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NR 26
TC 29
Z9 31
U1 0
U2 17
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0271-5317
J9 NUTR RES
JI Nutr. Res.
PD MAY
PY 2016
VL 36
IS 5
BP 402
EP 407
DI 10.1016/j.nutres.2016.01.003
PG 6
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA DK6GT
UT WOS:000375021400002
PM 27101758
DA 2025-06-11
ER

PT J
AU Di Luccia, B
   Crescenzo, R
   Mazzoli, A
   Cigliano, L
   Venditti, P
   Walser, JC
   Widmer, A
   Baccigalupi, L
   Ricca, E
   Iossa, S
AF Di Luccia, Blanda
   Crescenzo, Raffaella
   Mazzoli, Arianna
   Cigliano, Luisa
   Venditti, Paola
   Walser, Jean-Claude
   Widmer, Alex
   Baccigalupi, Loredana
   Ricca, Ezio
   Iossa, Susanna
TI Rescue of Fructose-Induced Metabolic Syndrome by Antibiotics or Faecal
   Transplantation in a Rat Model of Obesity
SO PLOS ONE
LA English
DT Article
ID GUT MICROBIOTA; INSULIN-RESISTANCE; DIET; ENDOTOXEMIA; CONSUMPTION;
   MODULATION; SEQUENCES; EPIDEMIC
AB A fructose-rich diet can induce metabolic syndrome, a combination of health disorders that increases the risk of diabetes and cardiovascular diseases. Diet is also known to alter the microbial composition of the gut, although it is not clear whether such alteration contributes to the development of metabolic syndrome. The aim of this work was to assess the possible link between the gut microbiota and the development of diet-induced metabolic syndrome in a rat model of obesity. Rats were fed either a standard or high-fructose diet. Groups of fructose- fed rats were treated with either antibiotics or faecal samples from control rats by oral gavage. Body composition, plasma metabolic parameters and markers of tissue oxidative stress were measured in all groups. A 16S DNA-sequencing approach was used to evaluate the bacterial composition of the gut of animals under different diets. The fructose-rich diet induced markers of metabolic syndrome, inflammation and oxidative stress, that were all significantly reduced when the animals were treated with antibiotic or faecal samples. The number of members of two bacterial genera, Coprococcus and Ruminococcus, was increased by the fructose-rich diet and reduced by both antibiotic and faecal treatments, pointing to a correlation between their abundance and the development of the metabolic syndrome. Our data indicate that in rats fed a fructose-rich diet the development of metabolic syndrome is directly correlated with variations of the gut content of specific bacterial taxa.
C1 [Di Luccia, Blanda; Crescenzo, Raffaella; Mazzoli, Arianna; Cigliano, Luisa; Venditti, Paola; Baccigalupi, Loredana; Ricca, Ezio; Iossa, Susanna] Univ Naples Federico II, Dept Biol, Naples, Italy.
   [Walser, Jean-Claude] ETH, Genet Div Ctr, Zurich, Switzerland.
   [Widmer, Alex] ETH, Inst Integrat Biol IBZ, Zurich, Switzerland.
C3 University of Naples Federico II; Swiss Federal Institutes of Technology
   Domain; ETH Zurich; Swiss Federal Institutes of Technology Domain; ETH
   Zurich
RP Iossa, S (corresponding author), Univ Naples Federico II, Dept Biol, Naples, Italy.
EM susiossa@unina.it
RI Ricca, Ezio/AAG-2998-2020; Cigliano, Luisa/AEL-3260-2022; Widmer,
   Alex/B-6841-2009; IOSSA, Susanna/O-1625-2016
OI Widmer, Alex/0000-0001-8253-5137; IOSSA, Susanna/0000-0001-6103-718X;
   Ricca, Ezio/0000-0002-7355-0332; mazzoli, arianna/0000-0003-4096-443X;
   Walser, Jean-Claude/0000-0003-1513-0783; Baccigalupi,
   Loredana/0000-0003-3070-161X
FU Universita Federico II di napoli, Project FARO
FX This work was supported by the Universita Federico II di napoli, Project
   FARO. The funders had no role in study design, data collection and
   analysis, decision to publish, or preparation of the manuscript.
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TC 138
Z9 145
U1 1
U2 62
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD AUG 5
PY 2015
VL 10
IS 8
AR e0134893
DI 10.1371/journal.pone.0134893
PG 19
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA CO3MH
UT WOS:000359061400124
PM 26244577
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Zhang, ER
   Li, J
   Liu, Y
   Dong, Z
   Wang, LY
   Zhao, C
AF Zhang, Ertao
   Li, Jie
   Liu, Yan
   Dong, Zhao
   Wang, Longyu
   Zhao, Can
TI Associations between serum uric acid and depression in US adults: An
   analysis of the national health and nutrition examination survey
   2007-2016
SO PLOS ONE
LA English
DT Article
ID METABOLIC SYNDROME; OXIDATIVE STRESS; HYPERURICEMIA; RISK
AB Limited research has specifically explored the gender-specific differences in relation to serum uric acid and depression. Therefore, the research aims to bridge that gap by exploring the relationships between serum uric acid and depression, stratified by gender, in U.S. adults. In this study, the participants comprised individuals from five consecutive survey cycles (NHANES 2007-2008-2015-2016), with 20,804 qualified participants incorporated into the research. The assessment of depression was conducted utilizing the Patient Health Questionnaire-9 (PHQ-9), and we calculated the weighted averages (95% CIs) for continuous variables and the percentages (95% CIs) for categorical variables among the chosen covariates. A multivariable logistic regression model with weights was utilized to assess the relationships between serum uric acid categories and depression status. In male subjects, uric acid levels may be linked inversely to depression. However, Tertile 3 (>= 303.3 mu mol/L) was more likely to develop depression than Tertile 1 (<249.8 <mu>mol/L) among women. The study shows that high serum uric acid level may reduce the incidence of depression in men, but in females, it is an independent factor that increases the risk of depression.
C1 [Zhang, Ertao; Dong, Zhao; Wang, Longyu; Zhao, Can] Changzhi Med Coll, Changzhi, Shanxi, Peoples R China.
   [Li, Jie; Liu, Yan] Datong Third Peoples Hosp, Dept endocrinol, Datong, Shanxi, Peoples R China.
C3 Changzhi Medical College
RP Li, J (corresponding author), Datong Third Peoples Hosp, Dept endocrinol, Datong, Shanxi, Peoples R China.
EM 2958026221@qq.com
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NR 25
TC 0
Z9 0
U1 2
U2 2
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD APR 8
PY 2025
VL 20
IS 4
AR e0321387
DI 10.1371/journal.pone.0321387
PG 10
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 1EO9I
UT WOS:001463174400003
PM 40198612
OA gold
DA 2025-06-11
ER

PT J
AU Liu, WN
   Liu, JT
   Xia, J
   Xue, XL
   Wang, HM
   Qi, ZT
   Ji, L
AF Liu, Weina
   Liu, Jiatong
   Xia, Jie
   Xue, Xiangli
   Wang, Hongmei
   Qi, Zhengtang
   Ji, Liu
TI Leptin receptor knockout-induced depression-like behaviors and
   attenuated antidepressant effects of exercise are associated with
   STAT3/SOCS3 signaling
SO BRAIN BEHAVIOR AND IMMUNITY
LA English
DT Article
DE Leptin receptor; Depression; Exercise; IKK beta/NF kappa B signaling;
   STAT3/SOCS3 signaling
ID INCREASED INSULIN SENSITIVITY; SELECTIVE DELETION; GENE-EXPRESSION;
   KAPPA-B; BRAIN; ACTIVATION; STRESS; MICE; RESISTANCE; MODEL
AB Relatively little has been known about pathophysiological mechanisms contributing to the development of neuropsychiatric symptoms in the context of metabolic syndrome. Impaired leptin signaling activation in db/db mice has been proposed as a potential link between behavioral and metabolic disorders. Our previous studies have shown that exercise has the beneficial effects on a depression-like and insulin resistant state in mice. The present study aimed to determine whether and how leptin receptor knockout (db/db) induces depression-like behaviors, and to identify the antidepressant effects of swimming exercise in db/db mice. Our results support the validity of db/db mice as an animal model to study depression with metabolic abnormalities, but fail to confirm the improvement of exercise on depression. LepRb knockout-induced depression-like behaviors are associated with STAT3/SOCS3 signaling but independent of IKK beta/NE kappa B signaling. Our findings suggest the potential importance of LepRb as an exercise-regulated target for depression, also representing a new target underlying treatment-resistant depression. (C) 2017 Elsevier Inc. All rights reserved.
C1 East China Normal Univ, Key Lab Adolescent Hlth Assessment & Exercise Int, Minist Educ, Shanghai 200241, Peoples R China.
   East China Normal Univ, Sch Phys Educ & Hlth Care, Shanghai 200241, Peoples R China.
C3 East China Normal University; Ministry of Education - China; East China
   Normal University
RP Qi, ZT; Ji, L (corresponding author), East China Normal Univ, Sch Phys Educ & Hlth Care, Key Lab Adolescent Hlth Assessment & Exercise Int, Minist Educ, 500 Dongchuan Rd, Shanghai 200241, Peoples R China.
EM gzht79@163.com; lji@tyxx.ecnu.edu.cn
RI Xia, Jie/K-8226-2014
OI xia, jie/0000-0002-2711-0352
FU National Natural Science Foundation of China [31300977]; Shanghai
   Pujiang Talent Plan [15PJC032]; Key Laboratory Construction Project of
   Adolescent Health Assessment and Exercise Intervention of Ministry of
   Education [40500-541235-4203/004]; Collaborative Innovation Center of
   POWER Project for Adolescent [44801400]
FX This work was supported by the National Natural Science Foundation of
   China (No. 31300977), Shanghai Pujiang Talent Plan (No. 15PJC032), the
   Key Laboratory Construction Project of Adolescent Health Assessment and
   Exercise Intervention of Ministry of Education (No.
   40500-541235-4203/004), and the Collaborative Innovation Center of POWER
   Project for Adolescent (No. 44801400).
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NR 76
TC 38
Z9 39
U1 1
U2 42
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0889-1591
EI 1090-2139
J9 BRAIN BEHAV IMMUN
JI Brain Behav. Immun.
PD MAR
PY 2017
VL 61
BP 297
EP 305
DI 10.1016/j.bbi.2017.01.001
PG 9
WC Immunology; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Immunology; Neurosciences & Neurology; Psychiatry
GA EM5PZ
UT WOS:000395365900032
PM 28069387
DA 2025-06-11
ER

PT J
AU Risérus, U
   Basu, S
   Jovinge, S
   Fredrikson, GN
   Ärnlöv, J
   Vessby, B
AF Risérus, U
   Basu, S
   Jovinge, S
   Fredrikson, GN
   Ärnlöv, J
   Vessby, B
TI Supplementation with conjugated linoleic acid causes isomer-dependent
   oxidative stress and elevated C-reactive protein -: A potential link to
   fatty acid-induced insulin resistance
SO CIRCULATION
LA English
DT Article
DE fatty acids; inflammation; free radicals; insulin; syndrome x
ID LIPID-PEROXIDATION; IN-VIVO; 8-ISO-PROSTAGLANDIN F2-ALPHA; ENDOTHELIAL
   DYSFUNCTION; METABOLIC SYNDROME; MEN; DISEASE; RADIOIMMUNOASSAY;
   F-2-ISOPROSTANES; ISOPROSTANES
AB Background-Conjugated linoleic acids (CLAs), a group of fatty acids shown to have beneficial effects in animals, are also used as weight loss supplements. Recently, we reported that the t10c12 CLA-isomer caused insulin resistance in abdominally obese men via unknown mechanisms. The aim of the present study was to examine whether CLA has isomer-specific effects on oxidative stress or inflammatory biomarkers and to investigate the relationship between these factors and induced insulin resistance.
   Methods and Results-In a double-blind placebo-controlled trial, 60 men with metabolic syndrome were randomized to one of 3 groups receiving t10c12 CLA, a CLA mixture, or placebo for 12 weeks. Insulin sensitivity (euglycemic clamp), serum lipids, in vivo lipid peroxidation (determined as urinary 8-iso-PGF(2alpha) [F2-isoprostanes]), 15-ketodihydro PGF(2alpha) plasma vitamin E, plasma C-reactive protein, tumor necrosis factor-a, and interleukin-6 were assessed before and after treatment. Supplementation with t10c12 CLA markedly increased 8-iso-PGF(2alpha) (578%) and C-reactive protein (110%) compared with placebo (P<0.0001 and P<0.01, respectively) and independent of changes in hyperglycemia or dyslipidemia. The increases in 8-iso-PGF(2alpha), but not in C-reactive protein, were significantly and independently related to aggravated insulin resistance. Oxidative stress was related to increased vitamin E levels, suggesting a compensatory mechanism.
   Conclusions-t10c12 CLA supplementation increases oxidative stress and inflammatory biomarkers in obese men. The oxidative stress seems closely related to induced insulin resistance, suggesting a link between the fatty acid-induced lipid peroxidation seen in the present study and insulin resistance. These unfavorable effects of t10c12 CLA might be of clinical importance with regard to cardiovascular disease, in consideration of the widespread use of dietary supplements containing this fatty acid.
C1 Uppsala Univ, Dept Publ Hlth & Caring Sci Geriatr, Clin Nutr Res Unit, S-75125 Uppsala, Sweden.
   Lund Univ, Univ Hosp MAS, Dept Med Cardiol, Lund, Sweden.
C3 Uppsala University; Lund University; Skane University Hospital
EM ulf.riserus@pubcare.uu.se
RI ärnlöv, Johan/AAF-2746-2019
OI Arnlov, Johan/0000-0002-6933-4637
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NR 32
TC 234
Z9 253
U1 0
U2 16
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0009-7322
EI 1524-4539
J9 CIRCULATION
JI Circulation
PD OCT 8
PY 2002
VL 106
IS 15
BP 1925
EP 1929
DI 10.1161/01.CIR.0000033589.15413.48
PG 5
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 604HE
UT WOS:000178610600020
PM 12370214
DA 2025-06-11
ER

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   Korman, Neil J.
   Kroshinsky, Daniela
   Lebwohl, Mark
   Lim, Henry W.
   Paller, Amy S.
   Parra, Sylvia L.
   Pathy, Arun L.
   Prater, Elizabeth Farley
   Rupani, Reena
   Siegel, Michael
   Stoff, Benjamin
   Strober, Bruce E.
   Wong, Emily B.
   Wu, Jashin J.
   Hariharan, Vidhya
   Menter, Alan
TI Joint AAD-NPF guidelines of care for the management and treatment of
   psoriasis with awareness and attention to comorbidities
SO JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
LA English
DT Article
DE alcohol; anxiety; cancer; cardiovascular disease; chronic obstructive
   pulmonary disease; clinical guidelines for psoriasis; comorbidities;
   congestive heart failure; depression; dermatology; diabetes; erectile
   dysfunction; guidelines; hyperlipidemia; hypertension; inflammatory
   bowel disease; malignancy; metabolic syndrome; obesity; obstructive
   sleep apnea; psoriasis; psoriatic arthritis; relationships; renal
   disease; sexual health; skin disease; smoking; uveitis; work
   productivity
ID LONG-TERM SAFETY; CHRONIC PLAQUE PSORIASIS; POPULATION-BASED-COHORT;
   NECROSIS-FACTOR-ALPHA; HIGH BLOOD-PRESSURE; ANTI-TNF THERAPY;
   QUALITY-OF-LIFE; CHOLESTEROL EFFLUX CAPACITY;
   INFLAMMATORY-BOWEL-DISEASE; PATIENT-REPORTED OUTCOMES
AB Psoriasis is a chronic, inflammatory, multisystem disease that affects up to 3.2% of the US population. This guideline addresses important clinical questions that arise in psoriasis management and care, providing recommendations on the basis of available evidence.
C1 [Elmets, Craig A.; Connor, Cody; Elewski, Boni E.] Univ Alabama Birmingham, Birmingham, AL 35294 USA.
   [Leonardi, Craig L.] Cent Dermatol, St Louis, MO USA.
   [Davis, Dawn M. R.] Mayo Clin, Rochester, MN USA.
   [Gelfand, Joel M.] Univ Penn, Philadelphia, PA 19104 USA.
   [Lichten, Jason; Kiselica, Matthew; Siegel, Michael] Natl Psoriasis Fdn, Portland, OR USA.
   [Mehta, Nehal N.] NHLBI, NIH, Bldg 10, Bethesda, MD 20892 USA.
   [Armstrong, April W.] Univ Southern Calif, Los Angeles, CA USA.
   [Cordoro, Kelly M.] Univ Calif San Francisco, Sch Med, Dept Dermatol, San Francisco, CA USA.
   [Gordon, Kenneth B.] Med Coll Wisconsin, Milwaukee, WI 53226 USA.
   [Gottlieb, Alice B.; Lebwohl, Mark] Icahn Sch Med Mt Sinai, Dept Dermatol, New York, NY 10029 USA.
   [Kaplan, Daniel H.] Univ Pittsburgh, Pittsburgh, PA USA.
   [Kavanaugh, Arthur] Univ Calif San Diego, San Diego, CA 92103 USA.
   [Kivelevitch, Dario; Menter, Alan] Baylor Scott & White, Dallas, TX USA.
   [Korman, Neil J.] Univ Hosp Cleveland, Med Ctr, Cleveland, OH 44106 USA.
   [Kroshinsky, Daniela] Massachusetts Gen Hosp, Boston, MA 02114 USA.
   [Rupani, Reena] Icahn Sch Med Mt Sinai, New York, NY 10029 USA.
   [Lim, Henry W.] Henry Ford Hosp, Dept Dermatol, Detroit, MI 48202 USA.
   [Paller, Amy S.] Northwestern Univ, Feinberg Sch Med, Chicago, IL 60611 USA.
   [Parra, Sylvia L.] Dermatol & Skin Surg, Sumter, SC USA.
   [Pathy, Arun L.] Colorado Permanente Med Grp, Centennial, CO USA.
   [Prater, Elizabeth Farley] Univ Oklahoma, Hlth Sci Ctr, Oklahoma City, OK USA.
   [Stoff, Benjamin] Emory Univ, Sch Med, Atlanta, GA USA.
   [Strober, Bruce E.] Univ Connecticut, Farmington, CT USA.
   [Strober, Bruce E.] Prob Med Res, Waterloo, ON, Canada.
   [Wong, Emily B.] San Antonio Uniformed Serv Hlth Educ Consortium, Joint Base San Antonio, TX USA.
   [Wu, Jashin J.] Dermatol Res & Educ Fdn, Irvine, CA USA.
   [Hariharan, Vidhya] Amer Acad Dermatol, Rosemont, PA USA.
C3 University of Alabama System; University of Alabama Birmingham; Mayo
   Clinic; University of Pennsylvania; National Institutes of Health (NIH)
   - USA; NIH National Heart Lung & Blood Institute (NHLBI); University of
   Southern California; University of California System; University of
   California San Francisco; Medical College of Wisconsin; Icahn School of
   Medicine at Mount Sinai; Pennsylvania Commonwealth System of Higher
   Education (PCSHE); University of Pittsburgh; University of California
   System; University of California San Diego; Baylor Health Care System;
   Baylor University Medical Center; University System of Ohio; Case
   Western Reserve University; Case Western Reserve University Hospital;
   University Hospitals of Cleveland; Harvard University; Harvard
   University Medical Affiliates; Massachusetts General Hospital; Icahn
   School of Medicine at Mount Sinai; Henry Ford Health System; Henry Ford
   Hospital; Northwestern University; Feinberg School of Medicine;
   University of Oklahoma System; University of Oklahoma Health Sciences
   Center; Emory University; University of Connecticut; San Antonio
   Military Medical Center
RP Elmets, CA (corresponding author), Univ Alabama Birmingham, Birmingham, AL 35294 USA.
RI Kivelevitch, Dario/M-6918-2019; Kroshinsky, Daniela/AAM-4608-2020;
   Mehta, Nehal/W-4669-2019; Kaplan, Daniel/N-2779-2013; Strober,
   Bruce/AAQ-6953-2020; Wong, Emily/JGM-0118-2023; Lim, HW/GRY-3517-2022
OI Kroshinsky, Daniela/0000-0002-4781-9676
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NR 206
TC 319
Z9 335
U1 6
U2 51
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0190-9622
EI 1097-6787
J9 J AM ACAD DERMATOL
JI J. Am. Acad. Dermatol.
PD APR
PY 2019
VL 80
IS 4
BP 1073
EP 1113
DI 10.1016/j.jaad.2018.11.058
PG 41
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA HO6KE
UT WOS:000461037700037
PM 30772097
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Wang, H
   Tan, YZ
   Mu, RH
   Tang, SS
   Liu, X
   Xing, SY
   Long, Y
   Yuan, DH
   Hong, H
AF Wang, Hao
   Tan, Yuan-Zhi
   Mu, Rong-Hao
   Tang, Su-Su
   Liu, Xiao
   Xing, Shu-Yun
   Long, Yan
   Yuan, Dan-Hua
   Hong, Hao
TI Takeda G Protein-Coupled Receptor 5 Modulates Depression-like Behaviors
   via Hippocampal CA3 Pyramidal Neurons Afferent to Dorsolateral Septum
SO BIOLOGICAL PSYCHIATRY
LA English
DT Article
ID LATERAL SEPTUM; SOCIAL DEFEAT; BILE-ACIDS; STRESS; ATROPHY;
   NEUROGENESIS; ADAPTATIONS; MORPHOLOGY; REWARD
AB BACKGROUND: Takeda G protein-coupled receptor 5 (TGR5) is recognized as a promising target for type 2 diabetes and metabolic syndrome; its expression has been demonstrated in the brain and is thought to be neuroprotective. Here, we hypothesize that dysfunction of central TGR5 may contribute to the pathogenesis of depression. METHODS: In well-established chronic social defeat stress (CSDS) and chronic restraint stress (CRS) models of depression, we investigated the functional roles of TGR5 in CA3 pyramidal neurons (PyNs) and underlying mechanisms of the neuronal circuit in depression (for in vivo studies, n = 10; for in vitro studies, n = 5-10) using fiber photometry; optogenetic, chemogenetic, pharmacological, and molecular profiling techniques; and behavioral tests. RESULTS: Both CSDS and CRS most significantly reduced TGR5 expression of hippocampal CA3 PyNs. Genetic overexpression of TGR5 in CA3 PyNs or intra-CA3 infusion of INT-777, a specific agonist, protected against CSDS and CRS, exerting significant antidepressant-like effects that were mediated via CA3 PyN activation. Conversely, genetic knockout or TGR5 knockdown in CA3 facilitated stress-induced depression-like behaviors. Re-expression of TGR5 in CA3 PyNs rather than infusion of INT-777 significantly improved depression-like behaviors in Tgr5 knockout mice exposed to CSDS or CRS. Silencing and stimulation of CA3 PyNs-somatostatin-GABAergic (gamma-aminobutyric acidergic) neurons of the dorsolateral septum circuit bidirectionally regulated depression-like behaviors, and blockade of this circuit abrogated the antidepressant-like effects from TGR5 activation of CA3 PyNs. CONCLUSIONS: These findings indicate that TGR5 can regulate depression via CA3 PyNs-somatostatin- GABAergic neurons of dorsolateral septum transmission, suggesting that TGR5 could be a novel target for developing antidepressants. https://doi.org/10.1016/j.biopsych.2020.11.018
C1 [Wang, Hao; Tan, Yuan-Zhi; Mu, Rong-Hao; Tang, Su-Su; Liu, Xiao; Xing, Shu-Yun; Long, Yan; Yuan, Dan-Hua; Hong, Hao] China Pharmaceut Univ, Dept Pharmacol, Key Lab Neuropsychiat Dis, Nanjing, Peoples R China.
C3 China Pharmaceutical University
RP Hong, H (corresponding author), China Pharmaceut Univ, Dept Pharmacol, Key Lab Neuropsychiat Dis, Nanjing, Peoples R China.
EM honghao@cpu.edu.cn
RI Tan, Yuan-Zhi/B-5118-2011; huang, yan/GWM-4747-2022; Wang,
   Jiani/G-8591-2019
FU National Natural Science Foundation of China [81773714, 81573413];
   Double First-Class University Project [CPU2018GF/GY**]
FX This work was supported by the National Natural Science Foundation of
   China (Grant Nos. 81773714 and 81573413 [to HH] ) and the Double
   FirstClass University Project (CPU2018GF/GY**) .
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NR 63
TC 48
Z9 49
U1 2
U2 45
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0006-3223
EI 1873-2402
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD JUN 1
PY 2021
VL 89
IS 11
BP 1084
EP 1095
DI 10.1016/j.biopsych.2020.11.018
EA MAY 2021
PG 12
WC Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Psychiatry
GA TH9NJ
UT WOS:000672409300010
PM 33536132
DA 2025-06-11
ER

PT J
AU Hjort, A
   Bergia, RE
   Vitale, M
   Costabile, G
   Giacco, R
   Riccardi, G
   Campbell, WW
   Landberg, R
AF Hjort, Anna
   Bergia, Robert E.
   Vitale, Marilena
   Costabile, Giuseppina
   Giacco, Rosalba
   Riccardi, Gabriele
   Campbell, Wayne W.
   Landberg, Rikard
TI Low- versus High-Glycemic Index Mediterranean-Style Eating Patterns
   Improved Some Domains of Health-Related Quality of Life but Not Sleep in
   Adults at Risk for Type 2 Diabetes: The MEDGICarb Randomized Controlled
   Trial
SO JOURNAL OF NUTRITION
LA English
DT Article
DE glycemic index; Mediterranean diet; well-being; sleep; glycemic control
ID SURVEY SF-36; DIET; ASSOCIATION; ADHERENCE; DURATION; TESTS; MOOD
AB Background: A healthy eating pattern such as the Mediterranean-style healthy eating pattern (MED-HEP) is associated with favorable effects on both cardiometabolic risk markers and self-reported health outcomes. Limited evidence exists regarding the influence of the glycemic index (GI) of carbohydrate foods consumed within a healthy eating pattern on self-reported health status and sleep. Objectives: To investigate the effects of a low- compared with high-GI MED-HEP on changes in health-related quality of life (HRQoL) and sleep. Methods: The MEDGICarb-intervention trial is a 12-wk randomized, controlled, parallel multi-center trial in adults with >= 2 features of the metabolic syndrome. Participants consumed an eu-energetic diet profiled as a MED-HEP with either low GI (experimental) or high GI (control). HRQoL and sleep were measured with Medical Outcomes Study 36-item short-form health survey version 2, Pittsburgh sleep quality index, and Epworth Sleepiness Scale at baseline and postintervention. Results: One hundred and sixty adults with >= 2 features of the metabolic syndrome completed the intervention [53% females, age 56 +/- 10 y, body mass index (kg/m(2)) 31.0 +/- 3.1]. Low- compared with high-GI MED-HEP resulted in differential changes between the groups in the HRQoL domains role physical [5.6 +/- 2.2 arbitrary units (AU) compared with -2.5 +/- 2.5 AU) and vitality (6.9 +/- 1.7 AU compared with 0.0 +/- 1.8 AU] (P < 0.05), which were driven mostly by improvements in the low-GI group. There were no significant differences between the MED-HEPs for changes in aggregated physical or mental components or for the other individual domains of HRQoL (physical functioning, bodily pain, general health, social functioning, role emotional, and mental health) or for sleep quality or daytime sleepiness. Conclusions: Low compared to high GI in the context of a MED-HEP resulted in modest improvements in some, but not all, health domains of HRQoL. No major differences were seen between the groups for measures of sleep. This trial was registered at clinicaltrials.gov as NCT03410719.
C1 [Hjort, Anna; Landberg, Rikard] Chalmers Univ Technol, Dept Life Sci, Div Food & Nutr Sci, Gothenburg, Sweden.
   [Bergia, Robert E.; Campbell, Wayne W.] Purdue Univ, Dept Nutr Sci, W Lafayette, IN USA.
   [Vitale, Marilena; Costabile, Giuseppina; Riccardi, Gabriele] Feder II Univ, Dept Clin Med & Surg, Diabet Nutr & Metab Unit, Naples, Italy.
   [Giacco, Rosalba] CNR, Inst Food Sci, Avellino, Italy.
C3 Chalmers University of Technology; Purdue University System; Purdue
   University; Consiglio Nazionale delle Ricerche (CNR); Istituto di
   Scienze dell' Alimentazione (ISA-CNR)
RP Hjort, A (corresponding author), Chalmers Univ Technol, Dept Life Sci, Div Food & Nutr Sci, Gothenburg, Sweden.
EM anna.hjort@chalmers.se
RI Vitale, Marilena/J-1457-2014; Costabile, Giuseppina/AAJ-8382-2020
OI Costabile, Giuseppina/0000-0001-5761-8002; Hjort,
   Anna/0009-0004-5559-4122
FU Barilla International; Barilla United States
FX This study was funded by Barilla International and Barilla United
   States. The funding sources had no role in the collection, analysis, and
   interpretation of data, in writing this or any other reports, and in the
   decision to submit the article for publication.
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NR 48
TC 0
Z9 0
U1 1
U2 3
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0022-3166
EI 1541-6100
J9 J NUTR
JI J. Nutr.
PD SEP
PY 2024
VL 154
IS 9
BP 2743
EP 2751
DI 10.1016/j.tjnut.2024.07.005
EA SEP 2024
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA F3S7J
UT WOS:001309060600001
PM 39004223
OA hybrid
DA 2025-06-11
ER

PT J
AU Jo, I
   Han, C
   Jo, SA
   Seo, JA
   Park, MH
   Kim, NH
AF Jo, Inho
   Han, Changsu
   Jo, Sangmee Ahn
   Seo, Ji Ah
   Park, Moon Ho
   Kim, Nan Hee
TI Low Levels of Plasma Agmatine in the Metabolic Syndrome
SO METABOLIC SYNDROME AND RELATED DISORDERS
LA English
DT Article
ID OXIDATIVE STRESS; MORTALITY; SUBSTANCE; RELEASE; CALCIUM
AB Background: The biophysiology of the amino acid L-arginine has been a field of active research. Agmatine, which is a metabolite of L-arginine, is known to participate in many biophysical reactions, including those in the cardiovascular system. We sought to investigate plasma agmatine levels in human subjects as a potential biomarker for the metabolic syndrome.
   Methods: Agmatine concentration was measured in plasma from 322 elderly participants in the Ansan Geriatric study. The metabolic syndrome was defined according to an Asian modified version of criteria established in the Third Report of the National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. We observed that the metabolic syndrome was associated with low levels of plasma agmatine concentration.
   Results: The mean plasma agmatine level in the metabolic syndrome group was lower than that in the non-metabolic syndrome group (79.42 ng/mL vs. 82.44 ng/mL, P = 0.024). Agmatine remained significant within the regression model after adjustment for different covariates (adjusted odds ratio, 0.962; 95% confidence interval, 0.933-0.993).
   Conclusions: We concluded that plasma agmatine levels were lower in subjects with the metabolic syndrome than in those without the metabolic syndrome.
C1 [Park, Moon Ho] Korea Univ, Coll Med, Dept Neurol, Ansan 425707, Gyeonggi Do, South Korea.
   [Jo, Inho] Ewha Womans Univ, Sch Med, Dept Mol Med, Seoul, South Korea.
   [Han, Changsu; Seo, Ji Ah; Park, Moon Ho; Kim, Nan Hee] Korea Univ, Coll Med, Geriatr Hlth Clin, Ansan 425707, Gyeonggi Do, South Korea.
   [Han, Changsu; Seo, Ji Ah; Park, Moon Ho; Kim, Nan Hee] Korea Univ, Coll Med, Res Inst, Ansan 425707, Gyeonggi Do, South Korea.
   [Han, Changsu] Korea Univ, Coll Med, Dept Psychiat, Ansan 425707, Gyeonggi Do, South Korea.
   [Seo, Ji Ah; Kim, Nan Hee] Korea Univ, Coll Med, Div Endocrinol & Metab, Dept Internal Med, Ansan 425707, Gyeonggi Do, South Korea.
C3 Korea University; Korea University Medicine (KU Medicine); Ewha Womans
   University; Korea University; Korea University Medicine (KU Medicine);
   Korea University; Korea University Medicine (KU Medicine); Korea
   University; Korea University Medicine (KU Medicine); Korea University;
   Korea University Medicine (KU Medicine)
RP Park, MH (corresponding author), Korea Univ, Coll Med, Dept Neurol, 516 Gojan 1 Dong, Ansan 425707, Gyeonggi Do, South Korea.
EM parkmuno@yahoo.co.kr
RI Kim, Nan/T-8627-2019; Jo, Inho/R-3581-2019; Han, Changsu/H-9926-2013
OI Park, Moon Ho/0000-0002-4892-3475; Kim, Nan Hee/0000-0003-4378-520X;
   Han, Changsu/0000-0002-4021-8907; Jo, Inho/0000-0001-6060-6416
FU National Institute of Health, Republic of Korea [091-4800-4845-300-260];
   Ministry of Health, Welfare and Family Affairs, Republic of Korea
   [A040042, A050079]
FX This work was supported by the Intramural Research Fund
   (091-4800-4845-300-260) from the National Institute of Health, Republic
   of Korea, and in part by grants from the Korea Health 21 R&D Project,
   Ministry of Health, Welfare and Family Affairs, Republic of Korea
   (A040042, A050079).
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NR 25
TC 6
Z9 7
U1 0
U2 5
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-4196
EI 1557-8518
J9 METAB SYNDR RELAT D
JI Metab. Syndr. Relat. Disord.
PD FEB
PY 2010
VL 8
IS 1
BP 21
EP 24
DI 10.1089/met.2009.0032
PG 4
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 559SE
UT WOS:000274846200003
PM 19929601
DA 2025-06-11
ER

PT J
AU Knudsen, L
   Lyons, JG
   O'Dea, K
   Christensen, DL
   Brimblecombe, JK
AF Knudsen, Lenette
   Lyons, Jasmine G.
   O'Dea, Kerin
   Christensen, Dirk L.
   Brimblecombe, Julie K.
TI Antioxidant biomarkers and cardiometabolic risk markers in an Aboriginal
   community in remote Australia: a cross-sectional study
SO PUBLIC HEALTH NUTRITION
LA English
DT Article
DE Plasma antioxidants; Quality of diet; Cardiometabolic risk; Indigenous
   people; Nutrition
ID C-REACTIVE PROTEIN; OXIDATIVE STRESS; FOLLOW-UP; CAROTENOID
   CONCENTRATIONS; INDIGENOUS AUSTRALIANS; KIDNEY-DISEASE; ARNHEM-LAND;
   POPULATION; PLASMA; DIET
AB Objective: High-quality diets, characterised by nutrient-rich foods, are one of the foundations for health and well-being. Indicators of diet quality, antioxidants, are associated with protection against cardiometabolic diseases. The current study explores relationships between plasma antioxidants and cardiometabolic risk among Aboriginal people in Australia. Design: As part of a community-driven health promotion programme, we conducted a cross-sectional study including a health-behaviour questionnaire, plasma antioxidants and cardiometabolic risk markers (anthropometric, blood pressure measurements, fasting glucose, glycated Hb (HbA(1c)), lipids, C-reactive protein and albumin-creatinine-ratio) continuous and categorised into population-specific cut-offs. Antioxidants (beta-carotene, beta-cryptoxanthin, lycopene, lutein-zeaxanthin, retinol and alpha-tocopherol measured using HPLC) were applied to a principal component analysis, which aggregated these into a single component. Linear regression models were applied to investigate associations between the antioxidant component and cardiometabolic risk markers. Setting: Community in a remote area in Northern Territory, Australia. Participants: A total of 324 Aboriginal people, mean age 35 center dot 5 (range 15-75) years. Results: Antioxidant component levels were higher among individuals with higher self-reported vegetable intake (P < 0 center dot 01), higher among individuals with higher self-reported fruit intake (P = 0 center dot 05) and lower among current smokers (P = 0 center dot 06). Linear regression revealed an inverse association between the antioxidant component and C-reactive protein (beta = -0 center dot 01, P < 0 center dot 01) after adjusting for confounders. Conclusion: Higher plasma antioxidant levels, indicators of diet quality, were associated with lower levels of high-sensitivity C-reactive protein in this Aboriginal population in remote Australia. This association suggests plasma antioxidants may be protective against inflammation; however, longitudinal studies are needed to examine this potentially protective relationship.
C1 [Knudsen, Lenette] Steno Diabet Ctr Copenhagen, Educat Dept, DK-2820 Gentofte, Denmark.
   [Lyons, Jasmine G.] Univ Melbourne, Med Dent & Hlth Sci, Melbourne, Vic, Australia.
   [O'Dea, Kerin] Univ South Australia, Sch Hlth Sci, Adelaide, SA, Australia.
   [O'Dea, Kerin] Univ Melbourne, Med Dent & Hlth Sci, Melbourne, Vic, Australia.
   [Christensen, Dirk L.] Univ Copenhagen, Dept Publ Hlth, Copenhagen, Denmark.
   [Brimblecombe, Julie K.] Monash Univ, Dept Nutr Dietet & Food, Clayton, Vic, Australia.
C3 Steno Diabetes Center; University of Melbourne; University of South
   Australia; University of Melbourne; University of Copenhagen; Monash
   University
RP Knudsen, L (corresponding author), Steno Diabet Ctr Copenhagen, Educat Dept, DK-2820 Gentofte, Denmark.
EM lenette.knudsen@regionh.dk
RI Lyons, Jasmine/D-1686-2013; Christensen, Dirk Lund/KMX-3660-2024
OI Christensen, Dirk Lund/0000-0003-2142-522X; Brimblecombe,
   Julie/0000-0002-1977-276X; Knudsen, Lenette/0000-0001-8969-4640
FU National Health and Medical Research Council of Australia [124319];
   Academy of Finland (AKA) [124319] Funding Source: Academy of Finland
   (AKA)
FX The current study was funded by the National Health and Medical Research
   Council of Australia (#124319).
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NR 71
TC 0
Z9 0
U1 0
U2 7
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 1368-9800
EI 1475-2727
J9 PUBLIC HEALTH NUTR
JI Public Health Nutr.
PD OCT
PY 2021
VL 24
IS 15
BP 4937
EP 4948
AR PII S1368980020004899
DI 10.1017/S1368980020004899
PG 12
WC Public, Environmental & Occupational Health; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health; Nutrition & Dietetics
GA UT6UG
UT WOS:000698249400019
PM 33261694
OA Green Published
DA 2025-06-11
ER

PT J
AU Leighton, F
   Miranda-Rottmann, S
   Urquiaga, I
AF Leighton, Federico
   Miranda-Rottmann, Soledad
   Urquiaga, Ines
TI A central role of eNOS in the protective effect of wine against
   metabolic syndrome
SO CELL BIOCHEMISTRY AND FUNCTION
LA English
DT Review
DE metabolic syndrome; red wine; Mediterranean diet; endothelial nitric
   oxide synthase; endothelial function; insulin resistance; hypertension;
   obesity; HDL
ID NITRIC-OXIDE SYNTHASE; CARDIOVASCULAR RISK-FACTORS; ACTIVATED
   RECEPTOR-GAMMA; HIGH-FAT DIET; RED WINE; INSULIN-RESISTANCE;
   ALCOHOL-CONSUMPTION; ENDOTHELIAL DYSFUNCTION; OXIDATIVE STRESS; MODERATE
   WINE
AB The positive health effects derived from moderate wine consumption are pleiotropic. They appear as improvements in cardiovascular risk factors such as plasma lipids, haemostatic mechanisms, endothelial function and antioxidant defences. The active principles would be ethanol and mainly polyphenols. Results from our and other laboratories support the unifying hypothesis that the improvements in risk factors after red wine consumption are mediated by endothelial nitric oxide synthase (eNOS). Many genes are involved, but the participation of eNOS would be a constant feature.
   The metabolic syndrome is a cluster of metabolic risk factors associated with high risk of cardiovascular disease (CVD). The National Cholesterol Education Programmmes Adult Treatment Panel III (NCEPATP III) clinical definition of the metabolic syndrome requires the presence of at least three risk factors, from among abdominal obesity, high plasma triacylglycerols, low plasma HDL, high blood pressure and high fasting plasma glucose. The molecular mechanisms responsible for the metabolic syndrome are not known. Since metabolic syndrome apparently affects 10-30% of the population in the world, research on its pathogenesis and control is needed.
   The recent finding that eNOS knockout mice present a cluster of cardiovascular risk factors comparable to those of the metabolic syndrome suggests that defects in eNOS function may cause human metabolic syndrome. These mice are hypertensive, insulin resistant and dyslipidemic. Further support for a pathogenic role of eNOS comes from the finding in humans that eNOS polymorphisms associate with insulin resistance and diabetes, with hypertension, with inflammatory and oxidative stress markers and with albuminuria. So, the data sustain the hypothesis that eNOS enhancement should reduce metabolic syndrome incidence and its consequences. Therefore red wine, since it enhances eNOS function, should be considered as a potential tool for the control of metabolic syndrome. This hypothesis is supported by epidemiological observations and needs experimental validation in human intervention studies. Copyright (c) 2005 John Wiley & Sons, Ltd.
C1 Catholic Univ Chile, Fac Ciencias Biol, Lab Nutr Mol, Santiago, Chile.
C3 Pontificia Universidad Catolica de Chile
RP Leighton, F (corresponding author), Catholic Univ Chile, Fac Ciencias Biol, Lab Nutr Mol, Casilla 114-D, Santiago, Chile.
EM fleighto@bio.puc.cl
RI Miranda-Rottmann, Soledad/A-9227-2009
OI Miranda Rottmann, Soledad/0000-0001-8384-8661
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NR 70
TC 28
Z9 32
U1 0
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0263-6484
EI 1099-0844
J9 CELL BIOCHEM FUNCT
JI Cell Biochem. Funct.
PD JUL-AUG
PY 2006
VL 24
IS 4
BP 291
EP 298
DI 10.1002/cbf.1269
PG 8
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA 063XI
UT WOS:000239052800002
PM 16170835
DA 2025-06-11
ER

PT J
AU Mulvahill, JS
   Nicol, GE
   Dixon, D
   Lenze, EJ
   Karp, JF
   Reynolds, CF
   Blumberger, DM
   Mulsant, BH
AF Mulvahill, John S.
   Nicol, Ginger E.
   Dixon, David
   Lenze, Eric J.
   Karp, Jordan F.
   Reynolds, Charles F., III
   Blumberger, Daniel M.
   Mulsant, Benoit H.
TI Effect of Metabolic Syndrome on Late-Life Depression: Associations with
   Disease Severity and Treatment Resistance
SO JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
LA English
DT Article
DE late-life depression; major depressive disorder; metabolic syndrome;
   elderly; venlafaxine
ID COMMUNITY-DWELLING JAPANESE; OLDER-ADULTS; FUNCTIONAL STATUS;
   PHYSICAL-ACTIVITY; SCREENING TOOL; MARITAL-STATUS; 3-YEAR COHORT;
   MORTALITY; IMPAIRMENT; SYMPTOMS
AB BACKGROUND/OBJECTIVES: Metabolic syndrome (MetS) is the co-occurrence of obesity and metabolic derangements. Prior research implicates MetS in prolongation of the course of depression in older adults, but its effect on antidepressant response is unknown in this population. The objective was to determine whether MetS and related metabolic dyscrasias are associated with decreased rate of remission from depression in older adults treated pharmacologically for depression.
   DESIGN: Secondary analysis of a randomized controlled trial.
   SETTING: Three academic medical centers in North America.
   PARTICIPANTS: Adults aged 60 and older (mean age 69.1) with major depressive disorder (MDD) (N = 435).
   INTERVENTION: Open-label, protocolized treatment with extended-release venlafaxine for 12 or more weeks.
   MEASUREMENTS: Time to remission from depression, with remission defined as a Montgomery-Asberg Depression Rating Scale (MADRS) score of 10 or less at last two visits.
   RESULTS: Two hundred twenty-two participants (51%) met criteria for MetS at baseline; MetS was associated with greater severity (MADRS score) and chronicity of depression at baseline. Remission was achieved in 182 participants (42%). In the unadjusted analysis, MetS was associated with prolonged time to remission (hazard ratio for remission = 0.71, 95% confidence interval = 0.52-0.95), but this relationship was not significant in the adjusted model; greater number of MetS components and lower high-density lipoprotein cholesterol had similar effects. Only diastolic blood pressure (DBP) was a significant predictor of time to remission before and after adjustment, with higher DBP predicting longer time to remission. Insulin sensitivity did not predict time to remission.
   CONCLUSION: The presence of MetS in older adults with depression was associated with greater symptom severity and chronicity of depression, which appears to have accounted for the poorer antidepressant response observed in those with MetS. Additionally, our preliminary finding of an association between higher DBP and poorer antidepressant response bears further examination and replication.
C1 [Mulvahill, John S.; Nicol, Ginger E.; Dixon, David; Lenze, Eric J.] Washington Univ, Sch Med, Dept Psychiat, Hlth Mind Lab, St Louis, MO 63110 USA.
   [Karp, Jordan F.; Reynolds, Charles F., III] Univ Pittsburgh, Sch Med, Pittsburgh, PA USA.
   [Blumberger, Daniel M.; Mulsant, Benoit H.] Univ Toronto, Ctr Addict & Mental Hlth, Toronto, ON, Canada.
   [Blumberger, Daniel M.; Mulsant, Benoit H.] Univ Toronto, Dept Psychiat, Toronto, ON, Canada.
C3 Washington University (WUSTL); Pennsylvania Commonwealth System of
   Higher Education (PCSHE); University of Pittsburgh; University of
   Toronto; Centre for Addiction & Mental Health - Canada; University of
   Toronto
RP Nicol, GE (corresponding author), 660 S Euclid Ave,CB 8134, St Louis, MO 63110 USA.
EM nicolg@wustl.edu
RI Lenze, Eric/AAW-8652-2021; Nicol, Ginger/AAN-1176-2021
OI Mulsant, Benoit/0000-0002-0303-6450; Lenze, Eric/0000-0002-0471-9368;
   Nicol, Ginger/0000-0001-5823-6129
FU University of Pittsburgh Medical Center Endowment in Geriatric
   Psychiatry; Taylor Family Institute for Innovative Psychiatric Research
   (at Washington University); Washington University Institute of Clinical
   and Translational Sciences from the National Center for Advancing
   Translational Sciences [UL1 TR000448]; Campbell Family Mental Health
   Research Institute at the Centre for Addiction and Mental Health in
   Toronto;  [R01 MH083648];  [R01 MH083643]
FX This research was also supported by R01 MH083648 to Washington
   University, and R01 MH083643 to University of Toronto), with additional
   funding provided by the University of Pittsburgh Medical Center
   Endowment in Geriatric Psychiatry, the Taylor Family Institute for
   Innovative Psychiatric Research (at Washington University), Washington
   University Institute of Clinical and Translational Sciences Grant UL1
   TR000448 from the National Center for Advancing Translational Sciences,
   and the Campbell Family Mental Health Research Institute at the Centre
   for Addiction and Mental Health in Toronto.
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NR 33
TC 29
Z9 32
U1 0
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0002-8614
EI 1532-5415
J9 J AM GERIATR SOC
JI J. Am. Geriatr. Soc.
PD DEC
PY 2017
VL 65
IS 12
BP 2651
EP 2658
DI 10.1111/jgs.15129
PG 8
WC Geriatrics & Gerontology; Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA FP7SD
UT WOS:000417836200017
PM 29235659
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Wajchenberg, BL
   Nery, M
   Cunha, MR
   da Silva, MER
AF Wajchenberg, Bernardo Leo
   Nery, Marcia
   Cunha, Maria Rosaria
   Rossi da Silva, Maria Elizabeth
TI Adipose tissue at the crossroads in the development of the metabolic
   syndrome, inflammation and atherosclerosis
SO ARQUIVOS BRASILEIROS DE ENDOCRINOLOGIA E METABOLOGIA
LA English
DT Review
DE Obesity; visceral and subcutaneous adipose tissue; low grade
   inflammation; atherosclerosis; metabolic syndrome
ID C-REACTIVE PROTEIN; INSULIN-RESISTANCE; OBESE WOMEN; DISEASE;
   ACTIVATION; STRESS; ORGAN; RISK
AB The authors analyze insulin resistance, the metabolic syndrome and endothelial dysfunction as consequence of a common antecedent, a low grade inflammation, indicating that in obesity there is a chronically activated inflammatory state of the adipose tissue. Furthermore, the inflammatory signaling is discussed according to the adipose tissue depot, visceral or subcutaneous. Arq Bras Endocrino: Metab. 2009;53(2):145-150.
C1 [Wajchenberg, Bernardo Leo; Nery, Marcia; Cunha, Maria Rosaria; Rossi da Silva, Maria Elizabeth] HC FMUSP, Serv Endocrinol, Sao Paulo, Brazil.
   [Wajchenberg, Bernardo Leo; Nery, Marcia; Cunha, Maria Rosaria; Rossi da Silva, Maria Elizabeth] HC FMUSP, InsCor, Ctr Diabet Coracao, Sao Paulo, Brazil.
C3 Universidade de Sao Paulo; Universidade de Sao Paulo
RP Wajchenberg, BL (corresponding author), Av Dr Arnaldo 455, BR-01246903 Sao Paulo, Brazil.
EM bernarwaj@globo.com
RI Silva, Maria/F-1081-2012; NERY, MARCIA/B-5735-2013
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NR 26
TC 34
Z9 41
U1 0
U2 2
PU SBEM-SOC BRASIL ENDOCRINOLOGIA & METABOLOGIA
PI RIO DE JANEIRO, RJ
PA RUA HUMAITA, 85 CJ 501, RIO DE JANEIRO, RJ, 22261-000, BRAZIL
SN 0004-2730
EI 1677-9487
J9 ARQ BRAS ENDOCRINOL
JI Arq. Bras. Endocrinol. Metabol.
PD MAR
PY 2009
VL 53
IS 2
BP 145
EP 150
DI 10.1590/S0004-27302009000200005
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 434QE
UT WOS:000265288400005
PM 19466206
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Violanti, JM
   Fekedulegn, D
   Andrew, ME
   Charles, LE
   Gu, JK
   Miller, DB
AF Violanti, John M.
   Fekedulegn, Desta
   Andrew, Michael E.
   Charles, Luenda E.
   Gu, Ja K.
   Miller, Diane B.
TI Subclinical Markers of Cardiovascular Disease Among Police Officers A
   Longitudinal Assessment of the Cortisol Awakening Response and Flow
   Mediated Artery Dilation
SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
LA English
DT Article
DE awakening cortisol; brachial reactivity; cardiovascular disease;
   flow-mediated dilation; police stress
ID ACUTE PSYCHOLOGICAL STRESS; LAW-ENFORCEMENT COHORT; ENDOTHELIAL
   DYSFUNCTION; METABOLIC SYNDROME; BRACHIAL-ARTERY; CORONARY
   CALCIFICATION; RISK; MORBIDITY; ATHEROSCLEROSIS; POPULATION
AB Objective: To examine the association of the cortisol awakening response (CAR) with change in brachial artery flow-mediated dilation (FMD%) in police officers over a 7-year period. Methods: Baseline CAR was obtained from four saliva samples taken 15 minutes apart immediately after awakening. Analysis of covariance was used to compare the change in FMD% (FMD% Follow-up-FMD% Baseline) across tertiles of area under the cortisol curve with respect to increase (AUCI). Regression analysis was use to assess trend. Results: Officers (n = 172; 81% men) had a mean +/- SD age of 41 +/- 7.6 years. Men in the lowest AUCI tertile (ie, atypical waking cortisol pattern) had a significantly larger 7-year mean decline in FMD% (mean +/- SE: -2.56 +/- 0.64) compared with men in the highest tertile (-0.89 +/- 0.69) (P = 0.0087). Conclusions: An awakening cortisol AUCI predicted worsening of FMD% approximately 7 years later among male officers.
C1 [Violanti, John M.] Univ Buffalo State Univ New York, Sch Publ Hlth & Hlth Profess, Dept Epidemiol & Environm Hlth, 270 Farber Hall, Buffalo, NY 14260 USA.
   [Fekedulegn, Desta; Andrew, Michael E.; Charles, Luenda E.; Gu, Ja K.] NIOSH, Biostat & Epidemiol Branch, Ctr Dis Control & Prevent, Morgantown, WV USA.
   [Miller, Diane B.] NIOSH, Toxicol & Mol Biol Branch, Hlth Effects Lab Div, Ctr Dis Control & Prevent, Morgantown, WV USA.
C3 State University of New York (SUNY) System; University at Buffalo, SUNY;
   Centers for Disease Control & Prevention - USA; National Institute for
   Occupational Safety & Health (NIOSH); Centers for Disease Control &
   Prevention - USA; National Institute for Occupational Safety & Health
   (NIOSH)
RP Violanti, JM (corresponding author), Univ Buffalo State Univ New York, Sch Publ Hlth & Hlth Profess, Dept Epidemiol & Environm Hlth, 270 Farber Hall, Buffalo, NY 14260 USA.
EM violanti@buffalo.edu
RI Charles, Luenda/H-6008-2011
OI /0000-0002-0245-5899
FU National Institute for Occupational Safety and Health (NIOSH)
   [200-2003-01580, 1R01Hoo9640-01]
FX This work was supported by the National Institute for Occupational
   Safety and Health (NIOSH), contract no. 200-2003-01580 and Grant
   1R01Hoo9640-01. The findings and conclusions in this report are those of
   the authors and do not necessarily represent the views of the National
   Institute for Occupational Safety and Health.
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NR 59
TC 5
Z9 6
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1076-2752
EI 1536-5948
J9 J OCCUP ENVIRON MED
JI J. Occup. Environ. Med.
PD SEP
PY 2018
VL 60
IS 9
BP 853
EP 859
DI 10.1097/JOM.0000000000001358
PG 7
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA GW0UV
UT WOS:000446585900027
PM 29787400
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Husni, ME
AF Husni, M. Elaine
TI Comorbidities in Psoriatic Arthritis
SO RHEUMATIC DISEASE CLINICS OF NORTH AMERICA
LA English
DT Article
DE Psoriatic arthritis; Comorbidity; Psoriasis; Management; Screening
ID TUMOR-NECROSIS-FACTOR; QUALITY-OF-LIFE; BONE-MINERAL DENSITY; MODIFYING
   ANTIRHEUMATIC DRUGS; INFLAMMATORY-BOWEL-DISEASE; NONSTEROIDAL
   ANTIINFLAMMATORY DRUGS; MAJOR CARDIOVASCULAR EVENTS; B-VIRUS
   REACTIVATION; TO-SEVERE PSORIASIS; BODY-MASS INDEX
AB Epidemiologic studies have shown that, in patients with psoriatic arthritis (PsA), associated comorbidities may occur more frequently than expected. This article discusses related comorbidities in patients with PsA. Identifying these comorbidities may affect the management and treatment decisions for these patients to ensure an optimal clinical outcome. All health care providers caring for patients with PsA should be aware of the relevant comorbidities and should have an understanding of how these comorbidities affect management. The common comorbidities include cardiovascular disease, metabolic syndrome, obesity, diabetes, fatty liver disease, inflammatory bowel disease, ophthalmic disease, kidney disease, osteoporosis, depression, and anxiety.
C1 Cleveland Clin, Dept Rheumat & Immunol Dis, Arthrit & Musculoskeletal Ctr, Clin Outcomes Res, Cleveland, OH 44195 USA.
C3 Cleveland Clinic Foundation
RP Husni, ME (corresponding author), Cleveland Clin, Dept Rheumat & Immunol Dis, Arthrit & Musculoskeletal Ctr, Clin Outcomes Res, Desk A50,9500 Euclid Ave, Cleveland, OH 44195 USA.
EM husnie@ccf.org
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NR 139
TC 96
Z9 101
U1 0
U2 16
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0889-857X
EI 1558-3163
J9 RHEUM DIS CLIN N AM
JI Rheum. Dis. Clin. North Am.
PD NOV
PY 2015
VL 41
IS 4
BP 677
EP +
DI 10.1016/j.rdc.2015.07.008
PG 23
WC Rheumatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Rheumatology
GA CV9JD
UT WOS:000364602600011
PM 26476226
DA 2025-06-11
ER

PT J
AU Miles, MV
   Morrison, JA
   Horn, PS
   Tang, PH
   Pesce, AJ
AF Miles, MV
   Morrison, JA
   Horn, PS
   Tang, PH
   Pesce, AJ
TI Coenzyme Q10 changes are associated with metabolic syndrome
SO CLINICA CHIMICA ACTA
LA English
DT Article
DE coenzyme Q(10); ubiquinone; ubiquinol; metabolic syndrome; antioxidant;
   oxidative stress
ID 3RD NATIONAL-HEALTH; C-REACTIVE PROTEIN; SCHOOL-CHILDREN; POSSIBLE
   MARKER; PLASMA; Q(10); LIPOPROTEINS; MITOCHONDRIA; POPULATION;
   PREVALENCE
AB Background: The purpose of this study was to determine whether coenzyme Q(10) (CoQ) concentrations and redox status are associated with components of the metabolic syndrome. Methods: This is a cross-sectional survey of 223 adults (28-78 years), who were drawn from the ongoing Princeton Follow-up Study in greater Cincinnati. Individuals were assessed for measures of fatness, blood pressure, glucose, lipid profiles, C-reactive protein (CRP), reduced CoQ (ubiquinol), oxidized CoQ (ubiquinone), total CoQ and CoQ redox ratio (ubiquinol/ubiquinone). Results: After adjusting for age, sex and race, we found that total CoQ, ubiquinol and CRP levels are significantly increased in metabolic syndrome. Comparison of minimal risk and high-risk metabolic syndrome groups indicates an increased CoQ redox ratio in the high risk group (p<0.05). Step-wise logistic regression analysis, using age, sex, race, (In)CRP, total cholesterol, LDL, ubiquinol, ubiquinone and total CoQ as predictors, shows that only age (p = 0.00 1), total CoQ adjusted for plasma lipids (p < 0.0001) and (In)CRP (p < 0.005) were significant predictors of metabolic syndrome. Conclusions: The presence of metabolic syndrome components are associated with increased plasma total CoQ and ubiquinol concentrations after adjusting for age, sex and race. An increase in CoQ redox ratio may indicate a gender-specific adaptive response to oxidative stress in females, but not males. (C) 2004 Elsevier B.V. All rights reserved.
C1 Cincinnati Childrens Hosp, Med Ctr, Dept Pediat, Div Pathol & Lab Med, Cincinnati, OH 45229 USA.
   Univ Cincinnati, Coll Med, Cincinnati, OH 45229 USA.
   Cincinnati Childrens Hosp, Med Ctr, Dept Pediat, Div Pediat Neurol, Cincinnati, OH 45229 USA.
   Cincinnati Childrens Hosp, Med Ctr, Dept Pediat, Div Cardiol, Cincinnati, OH 45229 USA.
   Univ Cincinnati, Dept Math Sci, Cincinnati, OH 45221 USA.
   Vet Affairs Med Ctr, Psychiat Serv, Cincinnati, OH 45220 USA.
   Univ Cincinnati, Med Ctr, Dept Pathol & Lab Med, Cincinnati, OH 45267 USA.
C3 Cincinnati Children's Hospital Medical Center; University System of
   Ohio; University of Cincinnati; Cincinnati Children's Hospital Medical
   Center; Cincinnati Children's Hospital Medical Center; University System
   of Ohio; University of Cincinnati; University System of Ohio; Case
   Western Reserve University; US Department of Veterans Affairs; Veterans
   Health Administration (VHA); Louis Stokes Cleveland Veterans Affairs
   Medical Center; Cincinnati VA Medical Center; University System of Ohio;
   University of Cincinnati
RP Cincinnati Childrens Hosp, Med Ctr, Dept Pediat, Div Pathol & Lab Med, OSB-5449,3333 Burnet Ave, Cincinnati, OH 45229 USA.
EM michael.miles@cchmc.org
OI Miles, Michael/0000-0002-6624-330X
FU NHLBI NIH HHS [HL62394] Funding Source: Medline
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NR 26
TC 36
Z9 42
U1 0
U2 2
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0009-8981
EI 1873-3492
J9 CLIN CHIM ACTA
JI Clin. Chim. Acta
PD JUN
PY 2004
VL 344
IS 1-2
BP 173
EP 179
DI 10.1016/j.cccn.2004.02.016
PG 7
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA 827LO
UT WOS:000221901500021
PM 15149886
DA 2025-06-11
ER

PT J
AU van der Pal, KC
   Koopman, ADM
   Lakerveld, J
   van der Heijden, AA
   Elders, PJ
   Beulens, JW
   Rutters, F
AF van der Pal, Kaira C.
   Koopman, Anitra D. M.
   Lakerveld, Jeroen
   van der Heijden, Amber A.
   Elders, Petra J.
   Beulens, Joline W.
   Rutters, Femke
TI The association between multiple sleep-related characteristics and the
   metabolic syndrome in the general population: the New Hoorn study
SO SLEEP MEDICINE
LA English
DT Article
DE Sleep duration; Insomnia; Day-time napping; Sleep medication;
   (Parameters) of metabolic syndrome
ID RISK; DURATION; QUALITY; HYPNOTICS
AB Background: Previous studies have investigated the association between sleep duration, insomnia, daytime napping and metabolic syndrome individually, but never conjointly. In addition, the association with sleep medication use has yet to be investigated. We aimed to examine the associations between these sleep-related characteristics and the metabolic syndrome, individually and conjointly, in a population-based cohort.
   Material and methods: We used cross-sectional data of 1679 participants from the New Hoorn study, 52.6% women and age 60.8 thorn 6.4y. Sleep duration, insomnia, and day-time napping were measured using validated questionnaires. The use of sleep medication was documented by the registration of dispensing labels. The metabolic syndrome was defined according to ATP III. Linear and Poisson regressions were used, and all analyses were adjusted for age, sex, education level, job status, smoking, physical activity, depression and BMI.
   Results: In our population-based cohort, 447 (26.6%) persons had the metabolic syndrome. Individual associations showed that, after correction, day-time napping for <= 30 min and >30 min was associated with a prevalence ratio for the metabolic syndrome of 1.28 (95% CI: 1.1-1.5) and 1.74 (95% CI: 1.4-2.2), respectively, compared to participants who did not nap. Sleep duration, insomnia, and sleep medication use were not associated with the metabolic syndrome individually. However, conjointly analyses showed that, after correction, having >= 2 sleep-related characteristics was associated with a PR of 1.36 (95% CI: 1.0-1.8) of having the metabolic syndrome, compared to having no sleep-related characteristics.
   Conclusion: Sleep-related characteristics were associated with a higher prevalence of the metabolic syndrome in the general population. (c) 2018 Elsevier B.V. All rights reserved.
C1 [van der Pal, Kaira C.; Koopman, Anitra D. M.; Lakerveld, Jeroen; Beulens, Joline W.; Rutters, Femke] Univ Amsterdam, Dept Epidemiol & Biostat, Med Ctr, Boelelaan 1089a, NL-1081 HV Amsterdam, Netherlands.
   [van der Pal, Kaira C.; Koopman, Anitra D. M.; Lakerveld, Jeroen; van der Heijden, Amber A.; Elders, Petra J.; Beulens, Joline W.; Rutters, Femke] Amsterdam Publ Hlth Res Inst, Amsterdam, Netherlands.
   [van der Heijden, Amber A.; Elders, Petra J.] Univ Amsterdam, Med Ctr, Dept Gen Practice, Amsterdam, Netherlands.
   [Beulens, Joline W.] Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands.
C3 University of Amsterdam; Vrije Universiteit Amsterdam; Vrije
   Universiteit Amsterdam; University of Amsterdam; Vrije Universiteit
   Amsterdam; Utrecht University; Utrecht University Medical Center
RP Rutters, F (corresponding author), Univ Amsterdam, Dept Epidemiol & Biostat, Med Ctr, Boelelaan 1089a, NL-1081 HV Amsterdam, Netherlands.
EM f.rutters@vumc.nl
RI Lakerveld, Jeroen/JMP-6377-2023
OI Beulens, Joline/0000-0002-4181-0937; Lakerveld,
   Jeroen/0000-0002-8551-6748; Elders, Petra/0000-0002-5907-7219
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NR 28
TC 27
Z9 27
U1 0
U2 5
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1389-9457
EI 1878-5506
J9 SLEEP MED
JI Sleep Med.
PD DEC
PY 2018
VL 52
BP 51
EP 57
DI 10.1016/j.sleep.2018.07.022
PG 7
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA HA5PJ
UT WOS:000450326800010
PM 30278295
DA 2025-06-11
ER

PT J
AU Kirby, M
AF Kirby, Mike
TI Testicular cancer: low testosterone and the metabolic syndrome
SO TRENDS IN UROLOGY & MENS HEALTH
LA English
DT Article
ID SERUM TESTOSTERONE; INCREASED RISK; LONG-TERM; MEN; MORTALITY; TRENDS;
   HYPOGONADISM; CHEMOTHERAPY; STRESS; HEALTH
AB Cure rates for stage 1 testicular cancer are reaching 100%. However, long-term treatment-related side effects pose their own health risks. Regular follow up and monitoring are important for early detection and timely treatment of conditions such as testosterone deficiency and metabolic syndrome.
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Z9 3
U1 0
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2044-3730
EI 2044-3749
J9 TREND UROL MENS HEAL
JI Trends Urol. Mens Health
PD JAN
PY 2020
VL 11
IS 1
BP 12
EP 17
PG 6
WC Urology & Nephrology
WE Emerging Sources Citation Index (ESCI)
SC Urology & Nephrology
GA KF7IZ
UT WOS:000509414200003
DA 2025-06-11
ER

PT J
AU Alfaro, FJ
   Gavrieli, A
   Saade-Lemus, P
   Lioutas, VA
   Upadhyay, J
   Novak, V
AF Alfaro, Freddy J.
   Gavrieli, Anna
   Saade-Lemus, Patricia
   Lioutas, Vasileios-Arsenios
   Upadhyay, Jagriti
   Novak, Vera
TI White matter microstructure and cognitive decline in metabolic syndrome:
   a review of diffusion tensor imaging
SO METABOLISM-CLINICAL AND EXPERIMENTAL
LA English
DT Review
DE Metabolic syndrome; White matter mictrostructure; Diffusion tensor
   imaging; Cognitive decline; Brain
ID BODY-MASS INDEX; SYSTOLIC BLOOD-PRESSURE; FAMILIAL HYPERCHOLESTEROLEMIA
   PATIENTS; TYPE-2 DIABETES-MELLITUS; PITUITARY-ADRENAL AXIS;
   CORONARY-HEART-DISEASE; BRAIN ATROPHY; ALZHEIMERS-DISEASE;
   INSULIN-RESISTANCE; OXIDATIVE STRESS
AB Metabolic syndrome is a cluster of cardiovascular risk factors defined by the presence of abdominal obesity, glucose intolerance, hypertension and/or dyslipidemia. It is a major public health epidemic worldwide, and a known risk factor for the development of cognitive dysfunction and dementia. Several studies have demonstrated a positive association between the presence of metabolic syndrome and worse cognitive outcomes, however, evidence of brain structure pathology is limited. Diffusion tensor imaging has offered new opportunities to detect microstructural white matter changes in metabolic syndrome, and a possibility to detect associations between functional and structural abnormalities. This review analyzes the impact of metabolic syndrome on white matter microstructural integrity, brain structure abnormalities and their relationship to cognitive function. Each of the metabolic syndrome components exerts a specific signature of white matter microstructural abnormalities. Metabolic syndrome and its components exert both additive/synergistic, as well as, independent effects on brain microstructure thus accelerating brain aging and cognitive decline. (C) 2017 Elsevier Inc. All rights reserved.
C1 [Alfaro, Freddy J.; Gavrieli, Anna; Saade-Lemus, Patricia; Lioutas, Vasileios-Arsenios; Novak, Vera] Harvard Med Sch, Beth Israel Deaconess Med Ctr, Dept Neurol, 185 Pilgrim Rd,Palmer 127, Boston, MA 02215 USA.
   [Upadhyay, Jagriti] Harvard Med Sch, Beth Israel Deaconess Med Ctr, Dept Endocrinol, 330 Brookline Ave, Boston, MA 02215 USA.
C3 Harvard University; Harvard Medical School; Harvard University Medical
   Affiliates; Beth Israel Deaconess Medical Center; Harvard University;
   Harvard University Medical Affiliates; Beth Israel Deaconess Medical
   Center; Harvard Medical School
RP Novak, V (corresponding author), Beth Israel Deaconess Med Ctr, Dept Neurol, 185 Pilgrim Rd,Palmer 127, Boston, MA 02215 USA.
EM falfarom@bidmc.harvard.edu; agavriel@bidmc.harvard.edu;
   asaadele@bidmc.harvard.edu; vlioutas@bidmc.harvard.edu;
   jupadhya@bidmc.harvard.edu; vnovak@bidmc.harvard.edu
FU National Insitutes of Health-National Institute of Diabetes and Kidney
   Diseases [R01-DK103902-01A2]
FX This study was supported by the National Insitutes of Health-National
   Institute of Diabetes and Kidney Diseases by grant R01-DK103902-01A2 to
   Vera Novak MD PhD.
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NR 210
TC 82
Z9 84
U1 0
U2 13
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0026-0495
EI 1532-8600
J9 METABOLISM
JI Metab.-Clin. Exp.
PD JAN
PY 2018
VL 78
BP 52
EP 68
DI 10.1016/j.metabol.2017.08.009
PG 17
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism
GA FQ8RP
UT WOS:000418631200005
PM 28920863
OA Bronze, Green Accepted
DA 2025-06-11
ER

PT J
AU Vaccarino, V
   Goldberg, J
   Magruder, KM
   Forsberg, CW
   Friedman, MJ
   Litz, BT
   Heagerty, PJ
   Huang, GD
   Gleason, TC
   Smith, NL
AF Vaccarino, Viola
   Goldberg, Jack
   Magruder, Kathryn M.
   Forsberg, Christopher W.
   Friedman, Matthew J.
   Litz, Brett T.
   Heagerty, Patrick J.
   Huang, Grant D.
   Gleason, Theresa C.
   Smith, Nicholas L.
TI Posttraumatic stress disorder and incidence of type-2 diabetes: A
   prospective twin study
SO JOURNAL OF PSYCHIATRIC RESEARCH
LA English
DT Article
DE Posttraumatic stress disorder; Diabetes; Twin studies; Epidemiology;
   Stress
ID METABOLIC SYNDROME; MAJOR DEPRESSION; MENTAL-HEALTH; ERA VETERANS;
   VIETNAM; ASSOCIATION; PREVALENCE; RISK; CARE; PARTICIPANTS
AB Growing evidence has linked posttraumatic stress disorder (PTSD) to insulin resistance and type-2 diabetes, but most previous studies were cross-sectional. We examined the association between PTSD and incidence of diabetes in a prospective study of middle-aged male twins from the Vietnam Era Twin Registry. Lifetime PTSD was diagnosed at baseline with the Diagnostic Interview Schedule (DIS) according to DSM-III-R criteria. Subthreshold PTSD was defined by meeting some, but not all, criteria for PTSD. A total of 4340 respondents without self-reported diabetes at baseline were included. Of these, 658 reported a new diagnosis of treated diabetes over a median of 19.4 years of follow-up. At baseline, twins with PTSD showed more behavioral and metabolic risk factors such as overweight and hypertension. The age-adjusted cumulative incidence of diabetes was significantly higher in twins with PTSD (18.9%) than those without PTSD (14.4%), [odds ratio (OR) = 1.4, 95% confidence interval (CI) 1.03-1.8], and intermediate in those with subthreshold PTSD (16.4%) (OR = 1.2, 95% CI 0.9-1.5, p for trend = 0.03). Adjustment for military, lifestyle and metabolic factors diminished the association. No significant association was found comparing twin pairs discordant for PTSD. In conclusion, PTSD was prospectively associated with a 40% increased risk of new-onset type-2 diabetes which was partially explained by a cluster of metabolic and behavioral risk factors known to influence insulin resistance. Shared biological or behavioral precursors which occur within families may lead to both PTSD and insulin resistance/diabetes. Thus, PTSD could be a marker of neuroendocrine and metabolic dysregulation which may lead to type-2 diabetes. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Vaccarino, Viola] Emory Univ, Dept Epidemiol, Atlanta, GA 30322 USA.
   [Goldberg, Jack; Forsberg, Christopher W.; Smith, Nicholas L.] VA Puget Sound Hlth Care Syst, Seattle Epidemiol Res & Informat Ctr, Seattle, WA USA.
   [Goldberg, Jack; Smith, Nicholas L.] Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA.
   [Magruder, Kathryn M.] Ralph H Johnson VA Med Ctr, Charleston, SC USA.
   [Magruder, Kathryn M.] Med Univ S Carolina, Dept Psychiat & Behav Sci, Charleston, SC 29425 USA.
   [Friedman, Matthew J.] White River Junction VA Med Ctr, VA Natl Ctr PTSD, White River Jct, VT USA.
   [Litz, Brett T.] VA Boston Healthcare Syst, Boston, MA USA.
   [Litz, Brett T.] Boston Univ, Boston, MA 02215 USA.
   [Heagerty, Patrick J.] Univ Washington, Dept Biostat, Seattle, WA 98195 USA.
   [Huang, Grant D.; Gleason, Theresa C.] VA Off Res & Dev, Cooperat Studies Program, Washington, DC USA.
C3 Emory University; US Department of Veterans Affairs; Veterans Health
   Administration (VHA); Vet Affairs Puget Sound Health Care System;
   University of Washington; University of Washington Seattle; US
   Department of Veterans Affairs; Veterans Health Administration (VHA);
   Ralph H Johnson VA Medical Center; Medical University of South Carolina;
   Harvard University; Harvard University Medical Affiliates; US Department
   of Veterans Affairs; Veterans Health Administration (VHA); VA Boston
   Healthcare System; Boston University; University of Washington;
   University of Washington Seattle
RP Vaccarino, V (corresponding author), Emory Univ, Rollins Sch Publ Hlth, Dept Epidemiol, 1518 Clifton Rd NE, Atlanta, GA 30322 USA.
EM viola.vaccarino@emory.edu
RI Magruder, Kathryn/V-1576-2019; Vaccarino, Viola/AAW-5600-2020
OI Vaccarino, Laura Viola/0000-0002-9054-0654; Litz,
   Brett/0000-0002-0479-8887
FU Cooperative Studies Program (CSP) of the Office of Research and
   Development, Clinical Science Research and Development, of the United
   States Department of Veterans Affairs (VA) [569]; National Institutes of
   Health [K24 HL077506]
FX The Cooperative Studies Program (CSP) of the Office of Research and
   Development, Clinical Science Research and Development, of the United
   States Department of Veterans Affairs (VA), has provided financial
   support for Cooperative Study #569 and the development and maintenance
   of the Vietnam Era Twin (VET) Registry. Dr. Viola Vaccarino was
   supported in part by a National Institutes of Health award K24 HL077506.
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NR 38
TC 57
Z9 60
U1 0
U2 17
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-3956
EI 1879-1379
J9 J PSYCHIATR RES
JI J. Psychiatr. Res.
PD SEP
PY 2014
VL 56
BP 158
EP 164
DI 10.1016/j.jpsychires.2014.05.019
PG 7
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA AN1BV
UT WOS:000340318600021
PM 24950602
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Peng, HL
   Qing, YM
   Han, L
   Fu, SF
   Li, JL
   Wang, SY
   Liu, DL
   Liu, LN
   Tan, YY
AF Peng, Hailing
   Qing, Yumin
   Han, Liu
   Fu, Shifeng
   Li, Jianglei
   Wang, Siyi
   Liu, Deliang
   Liu, Lini
   Tan, Yuyong
TI Effect of Antidepressants on Non-Alcoholic Fatty Liver Disease and their
   Underlying Mechanism
SO CURRENT MEDICINAL CHEMISTRY
LA English
DT Article; Early Access
DE Depression; non-alcoholic fatty liver disease; mirtazapine;
   pathogenesis; signaling pathway
ID HEPATIC LIPID-ACCUMULATION; MENTAL-DISORDER INPATIENTS; METABOLIC
   SYNDROME; MIRTAZAPINE; DEPRESSION; RISK; PREVALENCE; SCHIZOPHRENIA;
   INFLAMMATION; EXPRESSION
AB Introduction The high prevalence of Non-Alcoholic Fatty Liver Disease (NAFLD), a chronic progressive disease characterized by hepatic steatosis, poses a serious burden to human health. Depression and NAFLD share some common pathogenic mechanisms, and patients with depression are at an increased risk of NAFLD. The drug mirtazapine is commonly used in the treatment of depression, but it can also cause liver damage. However, whether mirtazapine induces or aggravates NAFLD remains uncertain. Thus, we evaluated the risk factors for NAFLD in patients with depression and the effects of mirtazapine on NAFLD in vitro.Methods Inpatients diagnosed with depression at the Second Xiangya Hospital of Central South University between 2019 and 2022 were included in this study, and NAFLD was determined using an abdominal ultrasound examination. The risk factors for the development of NAFLD in patients with depression were analyzed using logistic regression analysis. AML-12 and MIHA cell lines were used to observe the effects of mirtazapine on NAFLD using oil red O staining. RT-qPCR and western blotting were used to explore the molecular mechanism behind NAFLD development induced by mirtazapine.Results Logistic regression analysis showed that older age, use of mirtazapine or fluoxetine, longer duration of antidepressant use, and combined hyperlipidemia or T2DM were risk factors for NAFLD in patients with depression. in vitro experiments revealed a subsequent increase in the content of intracellular lipid droplets as mirtazapine concentration increased. Mechanistic studies showed that mirtazapine increased the expressions of TLR4, MyD88, IFN-gamma, IL-1 beta, IL-6, and TNF-alpha mRNA in hepatocytes. Moreover, the expressions of TLR4, MyD88, and p-NF-kappa B-p65 proteins increased in a dose-dependent manner.Conclusion Age, antidepressant type, duration of antidepressant use, and comorbidities could be risk factors for NAFLD in patients with depression. Furthermore, mirtazapine can cause steatosis in both AML-12 and MIHA cell lines and may promote the development of NAFLD through the TLR4/MyD88/NF-kappa B signaling pathway. This study lays a solid foundation for further research on depression and NAFLD and can contribute to the prevention and treatment of these two diseases.
C1 [Peng, Hailing; Qing, Yumin; Han, Liu; Fu, Shifeng; Li, Jianglei; Wang, Siyi; Liu, Deliang; Tan, Yuyong] Cent South Univ, Xiangya Hosp 2, Dept Gastroenterol, Changsha 410011, Peoples R China.
   [Peng, Hailing; Qing, Yumin; Han, Liu; Fu, Shifeng; Li, Jianglei; Wang, Siyi; Liu, Deliang; Tan, Yuyong] Cent South Univ, Res Ctr Digest Dis, Changsha 410011, Peoples R China.
   [Liu, Lini] Second Peoples Hosp Hunan Prov, Dept Psychiat, Changsha 410011, Peoples R China.
C3 Central South University; Central South University
RP Tan, YY (corresponding author), Cent South Univ, Xiangya Hosp 2, Dept Gastroenterol, Changsha 410011, Peoples R China.; Liu, LN (corresponding author), Second Peoples Hosp Hunan Prov, Dept Psychiat, Changsha 410011, Peoples R China.
EM unicorn3737@163.com; tanyuyong@csu.edu.cn
RI Liu, Deliang/JFJ-1644-2023; liu, lini/HLQ-4666-2023; Tan,
   Yuyong/GRX-2029-2022
FU Scientific Research Project of the Hunan Provincial Health Commission
   [202103030980]; Natural Science Foundation of Hunan Province
   [2022JJ30837]; National Key Clinical Specialty Scientific Research
   Project of Hunan Province
FX The work was supported by the Scientific Research Project of the Hunan
   Provincial Health Commission(No. 202103030980), the Natural Science
   Foundation of Hunan Province (No. 2022JJ30837), and the National Key
   Clinical Specialty Scientific Research Project of Hunan Province (Lini
   Liu).
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NR 50
TC 2
Z9 2
U1 0
U2 3
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 0929-8673
EI 1875-533X
J9 CURR MED CHEM
JI Curr. Med. Chem.
PD 2024 SEP 5
PY 2024
DI 10.2174/0109298673317281240828170031
EA SEP 2024
PG 13
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Pharmacology &
   Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
GA F2U0L
UT WOS:001308413500001
PM 39238390
DA 2025-06-11
ER

PT J
AU Devaraj, S
   Yimam, M
   Brownell, LA
   Jialal, I
   Singh, S
   Jia, Q
AF Devaraj, Sridevi
   Yimam, Mesfin
   Brownell, Lidia A.
   Jialal, Ishwarlal
   Singh, Sital
   Jia, Qi
TI Effects of Aloe vera Supplementation in Subjects with
   Prediabetes/Metabolic Syndrome
SO METABOLIC SYNDROME AND RELATED DISORDERS
LA English
DT Article
ID ANTIDIABETIC ACTIVITY; METABOLIC SYNDROME; CLINICAL-TRIAL; LEAF GEL;
   DIABETES-MELLITUS; OXIDATIVE STRESS; L JUICE; RATS; EXTRACT;
   F-2-ISOPROSTANES
AB Background: Metabolic syndrome affects 1 in 3 U.S. adults. The primary target of treatment of patients with metabolic syndrome is therapeutic lifestyle change. Numerous animal trials have reported positive effects of Aloe vera in in vivo models of diabetes, but there is a paucity of controlled clinical trials in patients with prediabetes. Thus, the objective of this pilot study was to examine the effect of aloe compared to placebo on fasting blood glucose, lipid profile, and oxidative stress in subjects with prediabetes/metabolic syndrome.
   Methods: This was a double-blind, placebo-controlled Institutional Review Board (IRB)-approved pilot study of two aloe products (UP780 and AC952) in patients with prediabetes over an 8-week period. A total of 45 subjects with impaired fasting glucose or impaired glucose tolerance and having two other features of metabolic syndrome were recruited (n = 15/group). Parameters of glycemia [fasting glucose, insulin, homeostasis model assessment (HOMA), glycosylated hemoglobin (HbA1c), fructosamine, and oral glucose tolerance test (OGTT)] and oxidative stress (urinary F2-isoprostanes) were measured along with lipid profile and high-sensitivity C-reactive protein (hsCRP) levels before and after supplementation.
   Results: There were no significant baseline differences between groups. Compared to placebo, only the AC952 Aloe vera inner leaf gel powder resulted in significant reduction in total and low-density lipoprotein cholesterol (LDL-C) levels, glucose, and fructosamine. In the UP780 Aloe vera inner leaf gel powder standardized with 2% aloesin group, there were significant reductions in HbA1c, fructosamine, fasting glucose, insulin, and HOMA. Only the UP780 aloe group had a significant reduction in the F2-isoprostanes compared to placebo.
   Conclusions: Standardized aloe preparations offer an attractive adjunctive strategy to revert the impaired fasting glucose and impaired glucose tolerance observed in conditions of prediabetes/metabolic syndrome.
C1 [Devaraj, Sridevi] Texas Childrens Hosp, Houston, TX 77030 USA.
   [Devaraj, Sridevi] Baylor Coll Med, Dept Pathol & Immunol, Houston, TX 77030 USA.
   [Yimam, Mesfin; Brownell, Lidia A.; Jia, Qi] Unigen Inc, Seattle, WA USA.
   [Jialal, Ishwarlal; Singh, Sital] UC Davis Med Ctr, Lab Atherosclerosis & Metab Res, Sacramento, CA USA.
C3 Baylor College of Medicine; Baylor College Medical Hospital; Baylor
   College of Medicine; University of California System; University of
   California Davis
RP Devaraj, S (corresponding author), Texas Childrens Hosp, 6621 Fannin St,Suite WB110-06, Houston, TX 77030 USA.
EM sxdevara@texaschildrens.org
RI Jialal, Ishwarlal/AAG-6218-2019
FU Unigen Inc.; AloeCorp.; Unigen
FX Unigen Inc., AloeCorp., for financial support and aloe products and
   placebo. S.D received a grant from Unigen and MY, LAB, QJ are employed
   at Unigen.
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NR 18
TC 54
Z9 58
U1 0
U2 45
PU MARY ANN LIEBERT INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-4196
J9 METAB SYNDR RELAT D
JI Metab. Syndr. Relat. Disord.
PD FEB
PY 2013
VL 11
IS 1
BP 35
EP 40
DI 10.1089/met.2012.0066
PG 6
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 076OF
UT WOS:000313965200007
PM 23035844
DA 2025-06-11
ER

PT J
AU Namazi, N
   Amani, M
   Haghighatkhah, HR
   Noori, E
   Abdollahimajd, F
AF Namazi, Nastaran
   Amani, Maliheh
   Haghighatkhah, Hamid Reza
   Noori, Ehsan
   Abdollahimajd, Fahimeh
TI Increased risk of subclinical atherosclerosis and metabolic syndrome in
   patients with vitiligo: a real association or a coincidence?
SO DERMATOLOGIC THERAPY
LA English
DT Article
DE atherosclerosis; cardiovascular diseases; intima&#8208; media thickness
   of the common carotid artery; metabolic syndrome; vitiligo
ID HIDRADENITIS SUPPURATIVA; OXIDATIVE STRESS; DISEASES
AB Inflammatory and autoimmune skin diseases such as vitiligo may be associated with systemic disorders, including endocrine and cardiovascular diseases, due to some similarities in the pathogenesis. It was aimed to evaluate metabolic syndrome and subclinical atherosclerosis in patients with vitiligo. Seventy patients with nonsegmental vitiligo and 70 age-matched and gender-matched healthy controls participated in the study. These participants were investigated for metabolic syndrome criteria. The mean intima-media thickness of the common carotid artery (MIMT-CCA) of the subjects was measured for assessment of subclinical atherosclerosis. Metabolic syndrome and subclinical atherosclerosis were significantly more frequent in vitiligo patients compared with the controls (P = .006 and P = .002, respectively). In addition, metabolic syndrome and subclinical atherosclerosis had positive, significant correlations with the severity and duration of vitiligo (P = .031 and r = .482; P < .01, respectively). Our study suggested that patients with vitiligo, especially those with more chronic and severe disease or concomitant metabolic syndrome, are at a higher risk of developing cardiovascular diseases. Therefore, early diagnosis and treatment of metabolic syndrome in patients with vitiligo to prevent cardiovascular complications were recommended.
C1 [Namazi, Nastaran; Amani, Maliheh; Abdollahimajd, Fahimeh] Shahid Beheshti Univ Med Sci, Skin Res Ctr, Tehran, Iran.
   [Haghighatkhah, Hamid Reza] Shahid Beheshti Univ Med Sci, Shohada Tajrish Hosp E, Dept Radiol, Tehran, Iran.
   [Haghighatkhah, Hamid Reza] Shahid Beheshti Univ Med Sci, Shohada Tajrish Hosp E, Med Imaging Ctr, Tehran, Iran.
   [Noori, Ehsan] Mashhad Univ Med Sci, Dept Anesthesiol, Mashhad, Razavi Khorasan, Iran.
   [Abdollahimajd, Fahimeh] Shahid Beheshti Univ Med Sci, Shohada Tajrish Hosp E, Clin Res Dev Unit, Tehran, Iran.
C3 Shahid Beheshti University Medical Sciences; Shahid Beheshti University
   Medical Sciences; Shahid Beheshti University Medical Sciences; Mashhad
   University of Medical Sciences; Shahid Beheshti University Medical
   Sciences
RP Abdollahimajd, F (corresponding author), Shahid Beheshti Univ Med Sci, Skin Res Ctr, Tehran, Iran.
EM fabdollahimajd@sbmu.ac.ir
RI Amani, Maliheh/AAY-2399-2020; Abdollahimajd, Fahimeh/AAZ-4160-2020;
   Haghighatkhah, Hamidreza/AAV-1260-2021; Namazi, Nastaran/O-3976-2015
OI Namazi, Nastaran/0000-0002-5411-8122
CR Abdollahimajd F, 2020, J AM ACAD DERMATOL, V82, P980, DOI 10.1016/j.jaad.2018.08.003
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NR 25
TC 15
Z9 15
U1 0
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1396-0296
EI 1529-8019
J9 DERMATOL THER
JI Dermatol. Ther.
PD MAR
PY 2021
VL 34
IS 2
AR e14803
DI 10.1111/dth.14803
EA FEB 2021
PG 6
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA RI3BL
UT WOS:000615992700001
PM 33496053
OA gold
DA 2025-06-11
ER

PT J
AU Ögüs, E
   Tekindal, MA
   Ceylan, Y
   Demirel, M
   Emecioglu, N
   Ercan, I
   Eroglu, D
   Haner, S
AF Ogus, Ersin
   Tekindal, Mustafa Agah
   Ceylan, Yelda
   Demirel, Merve
   Emecioglu, Nese
   Ercan, Ilcim
   Eroglu, Deniz
   Haner, Sevinc
TI Risks of Metabolic Syndrome in Students of the Faculty of Health
   Sciences
SO BALKAN MEDICAL JOURNAL
LA English
DT Article
DE Metabolic syndrome; risk factors; health education
ID SLEEP DURATION; OVERWEIGHT
AB Background: Metabolic syndrome is highly prevalent in the adult population worldwide. Education may play an important role in preventing metabolic syndrome in young adults, especially those who are attending university. Such adults are at a critical point in their lives and make their own lifestyle choices that can affect their future health.
   Aims: The aims of this study were to determine the metabolic syndrome risk levels of students from the Faculty of Health Sciences.
   Study Design: Survey design study.
   Methods: In a questionnaire developed by the researchers to collect data in accordance with the relevant literature, the scale of the risk of metabolic syndrome was assessed. A stepwise logistic regression analysis was performed to determine the risks.
   Results: Important risk factors for metabolic syndrome were found to be gender, weight gain, "stress eating" excessive amounts of food, sleeping for more than 8 hours a day, feeling tired after sleep, belonging to a divided family, and eating whilst working on the computer.
   Conclusion: The students from the Faculty of Health Sciences, particularly because they are trained in the health sector, are expected to have more information about the risk factors of metabolic syndrome, and take necessary precautions to prevent it.
C1 [Ogus, Ersin; Tekindal, Mustafa Agah] Baskent Univ, Fac Med, Dept Biostat, TR-06490 Ankara, Turkey.
   [Ceylan, Yelda; Demirel, Merve; Emecioglu, Nese; Ercan, Ilcim; Eroglu, Deniz; Haner, Sevinc] Baskent Univ, Fac Hlth Sci, TR-06490 Ankara, Turkey.
C3 Baskent University; Baskent University
RP Ögüs, E (corresponding author), Baskent Univ, Fac Med, Dept Biostat, TR-06490 Ankara, Turkey.
EM eogus@baskent.edu.tr
RI Tekindal, Mustafa/U-9270-2018
OI Tekindal, Mustafa Agah/0000-0002-4060-7048; Ogus,
   Ersin/0000-0002-9877-421X
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   The Society of Endocrinology and Metabolizm of Turkey, 2009, MET SYNDR GUID 2009
   Zellner DA, 2006, PHYSIOL BEHAV, V87, P789, DOI 10.1016/j.physbeh.2006.01.014
NR 23
TC 1
Z9 1
U1 0
U2 8
PU GALENOS PUBL HOUSE
PI ISTANBUL
PA  MOLLA GURANI MAHALLESI KACAMAK SOKAK NO 21-1, ISTANBUL, TURKEY
SN 2146-3123
EI 2146-3131
J9 BALK MED J
JI Balk. Med. J.
PD SEP
PY 2013
VL 30
IS 3
BP 296
EP 300
DI 10.5152/balkanmedj.2013.7145
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 220QZ
UT WOS:000324603300009
PM 25207123
OA Green Submitted, gold, Green Published
DA 2025-06-11
ER

PT J
AU Hildrum, B
   Mykletun, A
   Dahl, AA
   Midthjell, K
AF Hildrum, B.
   Mykletun, A.
   Dahl, A. A.
   Midthjell, K.
TI Metabolic syndrome and risk of mortality in middle-aged versus elderly
   individuals: the Nord-Trondelag Health Study (HUNT)
SO DIABETOLOGIA
LA English
DT Article
DE Age-specific risk; Cardiovascular disease; Epidemiology; Framingham risk
   score; Metabolic syndrome; Mortality
ID INTERNATIONAL-DIABETES-FEDERATION; CHOLESTEROL EDUCATION-PROGRAM;
   CARDIOVASCULAR-DISEASE; PREDICTION; DEFINITIONS; HEART; PREVALENCE;
   OVERWEIGHT; DEPRESSION; DIAGNOSIS
AB Recent reviews indicate that the metabolic syndrome is a risk factor for cardiovascular disease and mortality, but evidence is scarce in elderly individuals. We therefore examined the relationship between the metabolic syndrome and mortality rates among individuals aged 40-59, 60-74 and 75-89 years. We also examined whether the syndrome was associated with mortality rates over and above the Framingham risk score.
   We studied prospectively 6,748 men and women who participated in the Nord-Trondelag Health Study, Norway, from 1995 to 1997 (HUNT 2) and defined the metabolic syndrome by the International Diabetes Federation criteria.
   During 53,617 person-years of follow-up (mean per person, 7.9 years), 955 individuals died, of whom 585 died from cardiovascular disease. Among individuals who were 40-59 years of age at baseline, the presence of the metabolic syndrome was associated with increased relative risk of cardiovascular and total mortality (age- and sex-adjusted hazard ratios 3.97 [95% CI: 2.00-7.88] and 2.06 [1.35-3.13], respectively, equivalent to population-attributable risks of 20.7 and 14.2%, respectively). The Framingham risk score accounted for less than one-third of the effect of metabolic syndrome on mortality rates. After the age of 60 years, the metabolic syndrome was not associated with increased mortality rates. We found a significant interaction between the metabolic syndrome and age on the relative risk of mortality. Results were confirmed in a sub-sample without cardiovascular disease at baseline.
   The metabolic syndrome is a risk factor for mortality, over and above the Framingham risk score, in middle-aged, but not in elderly individuals.
C1 [Hildrum, B.] Namsos Hosp, Nord Trondelag Hosp Trust, Dept Psychiat, N-7800 Namsos, Norway.
   [Hildrum, B.] Norwegian Univ Sci & Technol, Fac Med, Dept Neurosci, N-7034 Trondheim, Norway.
   [Mykletun, A.] Univ Bergen, Fac Psychol, Res Ctr Hlth Promot, Bergen, Norway.
   [Mykletun, A.] Norwegian Inst Publ Hlth, Div Mental Hlth, Oslo, Norway.
   [Dahl, A. A.] Norwegian Radium Hosp, Oslo Univ Clin, Dept Clin Canc Res, Oslo, Norway.
   [Dahl, A. A.] Univ Oslo, Norwegian Radium Hosp, Fac Div, Oslo, Norway.
   [Midthjell, K.] Norwegian Univ Sci & Technol, HUNT Res Ctr, Dept Publ Hlth & Gen Practice, Verdal, Norway.
C3 Norwegian University of Science & Technology (NTNU); University of
   Bergen; Norwegian Institute of Public Health (NIPH); University of Oslo;
   University of Oslo; Norwegian University of Science & Technology (NTNU)
RP Hildrum, B (corresponding author), Namsos Hosp, Nord Trondelag Hosp Trust, Dept Psychiat, N-7800 Namsos, Norway.
EM bjorn.hildrum@hnt.no
RI Mykletun, Arnstein/L-5004-2015
OI Mykletun, Arnstein/0000-0002-3878-0079
CR Adams KF, 2006, NEW ENGL J MED, V355, P763, DOI 10.1056/NEJMoa055643
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NR 34
TC 47
Z9 48
U1 0
U2 1
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0012-186X
EI 1432-0428
J9 DIABETOLOGIA
JI Diabetologia
PD APR
PY 2009
VL 52
IS 4
BP 583
EP 590
DI 10.1007/s00125-009-1271-5
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism
GA 413IR
UT WOS:000263787300005
PM 19194692
OA Bronze
DA 2025-06-11
ER

PT J
AU Dludla, PV
   Orlando, P
   Silvestri, S
   Marcheggiani, F
   Cirilli, I
   Nyambuya, TM
   Mxinwa, V
   Mokgalaboni, K
   Nkambule, BB
   Johnson, R
   Mazibuko-Mbeje, SE
   Muller, CJF
   Louw, J
   Tiano, L
AF Dludla, Phiwayinkosi V.
   Orlando, Patrick
   Silvestri, Sonia
   Marcheggiani, Fabio
   Cirilli, Ilenia
   Nyambuya, Tawanda M.
   Mxinwa, Vuyolwethu
   Mokgalaboni, Kabelo
   Nkambule, Bongani B.
   Johnson, Rabia
   Mazibuko-Mbeje, Sithandiwe E.
   Muller, Christo J. F.
   Louw, Johan
   Tiano, Luca
TI Coenzyme Q10 Supplementation Improves Adipokine Levels and
   Alleviates Inflammation and Lipid Peroxidation in Conditions of
   Metabolic Syndrome: A Meta-Analysis of Randomized Controlled Trials
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE coenzyme Q(10); ubiquinone; metabolic syndrome; metabolic complications;
   non-alcoholic fatty liver disease; hypertension; adipokines;
   inflammation; oxidative stress; lipid peroxidation
ID FATTY LIVER-DISEASE; DIABETES-MELLITUS; OBESE-PATIENTS; DOUBLE-BLIND;
   ADIPONECTIN; QUALITY; DYSLIPIDEMIA; BIOMARKERS; OVERWEIGHT; PENTRAXIN
AB Evidence from randomized controlled trials (RCTs) suggests that coenzyme Q(10) (CoQ(10)) can regulate adipokine levels to impact inflammation and oxidative stress in conditions of metabolic syndrome. Here, prominent electronic databases such as MEDLINE, Cochrane Library, and EMBASE were searched for eligible RCTs reporting on any correlation between adipokine levels and modulation of inflammation and oxidative stress in individuals with metabolic syndrome taking CoQ(10). The risk of bias was assessed using the modified Black and Downs checklist, while the Grading of Recommendations Assessment, Development and Evaluation (GRADE) tool was used to evaluate the quality of evidence. Results from the current meta-analysis, involving 318 participants, showed that CoQ(10) supplementation in individuals with metabolic syndrome increased adiponectin levels when compared to those on placebo (SMD: 1.44 [95% CI: -0.13, 3.00]; I-2 = 96%, p < 0.00001). Moreover, CoQ(10) supplementation significantly lowered inflammation markers in individuals with metabolic syndrome in comparison to those on placebo (SMD: -0.31 [95% CI: -0.54, -0.08]; I-2 = 51%, p = 0.07). Such benefits with CoQ(10) supplementation were related to its ameliorative effects on lipid peroxidation by reducing malondialdehyde levels, concomitant to improving glucose control and liver function. The overall findings suggest that optimal regulation of adipokine function is crucial for the beneficial effects of CoQ(10) in improving metabolic health.
C1 [Dludla, Phiwayinkosi V.; Johnson, Rabia; Muller, Christo J. F.; Louw, Johan] South African Med Res Council, Biomed Res & Innovat Platform, ZA-7505 Tygerberg, South Africa.
   [Dludla, Phiwayinkosi V.; Orlando, Patrick; Silvestri, Sonia; Marcheggiani, Fabio; Cirilli, Ilenia; Tiano, Luca] Polytech Univ Marche, Dept Life & Environm Sci, I-60131 Ancona, Italy.
   [Cirilli, Ilenia] Univ Camerino, Sch Pharm, I-62032 Camerino, Italy.
   [Nyambuya, Tawanda M.; Mxinwa, Vuyolwethu; Mokgalaboni, Kabelo; Nkambule, Bongani B.] Univ KwaZulu Natal, Coll Hlth Sci, Sch Lab Med & Med Sci, ZA-4000 Durban, South Africa.
   [Nyambuya, Tawanda M.] Namibia Univ Sci & Technol, Fac Hlth & Appl Sci, Dept Hlth Sci, Windhoek 9000, Namibia.
   [Muller, Christo J. F.] Stellenbosch Univ, Fac Hlth Sci, Div Med Physiol, ZA-7505 Tygerberg, South Africa.
   [Mazibuko-Mbeje, Sithandiwe E.] North West Univ, Fac Nat & Agr Sci, Dept Biochem, ZA-2745 Mmabatho, South Africa.
   [Muller, Christo J. F.; Louw, Johan] Univ Zululand, Dept Biochem & Microbiol, ZA-3880 Kwa Dlangezwa, South Africa.
C3 South African Medical Research Council; Marche Polytechnic University;
   University of Camerino; University of Kwazulu Natal; Namibia University
   of Science & Technology; Stellenbosch University; North West University
   - South Africa; University of Zululand
RP Tiano, L (corresponding author), Polytech Univ Marche, Dept Life & Environm Sci, I-60131 Ancona, Italy.
EM pdludla@mrc.ac.za; p.orlando@univpm.it; s.silvestri@univpm.it;
   f.marcheggiani@univpm.it; ilenia.cirilli@unicam.it; mnyambuya@nust.na;
   218081787@stu.ukzn.ac.za; 218086707@stu.ukzn.ac.za;
   nkambuleb@ukzn.ac.za; rabia.johnson@mrc.ac.za;
   sithandiwe.mazibukombeje@gmail.com; christo.muller@mrc.ac.za;
   johan.louw@mrc.ac.za; l.tiano@univpm.it
RI Mazibuko-Mbeje, Sithandiwe/HPG-1119-2023; Nyambuya, Tawanda
   Maurice/GLU-4124-2022; Johnson, Rabia/ADW-4478-2022; Mokgalaboni,
   Kabelo/ACZ-1282-2022; Nkambule, Bongani/ABD-7943-2022; Orlando,
   Patrick/LSJ-0851-2024; Tiano, Luca/ABC-2341-2020
OI Johnson, Rabia/0000-0002-6328-0789; Nkambule,
   Bongani/0000-0001-8846-1992; Muller, Christo/0000-0001-6821-2120;
   Dludla, Phiwayinkosi/0000-0001-5965-3610; Mokgalaboni,
   Kabelo/0000-0002-3224-7433; Orlando, Patrick/0000-0002-4203-9611;
   Marcheggiani, Fabio/0000-0002-3272-7525; Nyambuya, Tawanda
   Maurice/0000-0002-3288-9524; Tiano, Luca/0000-0002-7519-7106; Cirilli,
   Ilenia/0000-0001-6916-5426; Mxinwa, Vuyolwethu/0000-0002-7680-4406
FU Biomedical Research and Innovation Platform of the South African Medical
   Research Council (SAMRC); National Research Foundation [117829]; SAMRC
   through its division of Research Capacity Development under the
   Intra-Mural Postdoctoral Fellowship Programme from the South African
   Treasury
FX This research was funded in part by baseline funding from the Biomedical
   Research and Innovation Platform of the South African Medical Research
   Council (SAMRC) and the National Research Foundation (Grant number:
   117829). P.V.D. was partially supported as a Post-Doctoral Fellow by
   funding from the SAMRC through its division of Research Capacity
   Development under the Intra-Mural Postdoctoral Fellowship Programme from
   funding received from the South African Treasury. The content hereof is
   the sole responsibility of the authors and do not necessarily represent
   the official views of the SAMRC or the funders.
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NR 68
TC 42
Z9 43
U1 0
U2 12
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD MAY
PY 2020
VL 21
IS 9
AR 3247
DI 10.3390/ijms21093247
PG 14
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA LR3GK
UT WOS:000535581700218
PM 32375340
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Cui, J
   Sun, XF
   Li, XJ
   Ke, M
   Sun, JP
   Yasmeen, N
   Khan, JM
   Xin, HL
   Xue, SY
   Baloch, Z
AF Cui, Jing
   Sun, Xiufen
   Li, Xiaojing
   Ke, Ma
   Sun, Jianping
   Yasmeen, Nafeesa
   Khan, Jamal Muhammad
   Xin, Hualei
   Xue, Shouyong
   Baloch, Zulqarnain
TI Association Between Different Indicators of Obesity and Depression in
   Adults in Qingdao, China: A Cross-Sectional Study
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Article
DE depression; body mass index; waist circumference; waist-to-hip ratio;
   ross-sectional study
ID BODY-MASS INDEX; METABOLIC SYNDROME; SYMPTOMS; HEALTH; POPULATION;
   OVERWEIGHT; ANXIETY; PEOPLE; IMPACT; IMAGE
AB Background: This study was designed to investigate the perceived relationship between body weight and depression risk in a Chinese population in Qingdao, China.
   Methods: A population-based cross-sectional survey was performed with 4,573 participants (between 35 and 74 years) from the year 2009 to 2012 in Qingdao, China. We applied the Zung self-rating depression scale to ascertain the level of depression in participants. The associations between different indicators of obesity [body mass index (BMI), waist circumference (WC), and waist-to-hip ratio (WHR)] and depression were assessed by logistic regression based on the Chinese criteria of obesity. Sensitivity analysis was done based on the Asian and WHO criteria of obesity.
   Results: The Zung scores for the 243 participants (5.2%) were over 45 and they were entitled as depression. Furthermore, multivariable logistic analyses revealed that being overweight [odds ratios (OR): 1.48, 95% confidence intervals [95% CI]: 1.08-2.03] and having abdominal obesity (WC category in Chinese criteria) (OR: 1.47, 95% CI: 1.08-2.00) were often associated with a higher risk for depression compared to normal weight subjects. Sensitivity analysis revealed that abdominal obesity (Asian criterion) (OR: 1.41, 95% CI: 1.03-1.91) was a significant risk factor for depression. Similarly, being overweight (WHO criterion) (OR: 1.39, 95% CI: 1.03-1.87) was an obvious risk factor for depression.
   Conclusion: Being overweight and having abdominal obesity (WC category) were found to be linked with a higher risk of depression. However, abdominal obesity (WHR category) was not associated with depression.
C1 [Cui, Jing; Li, Xiaojing; Sun, Jianping; Xin, Hualei] Qingdao Municipal Ctr Dis Control & Prevent, Qingdao, Peoples R China.
   [Cui, Jing; Li, Xiaojing; Sun, Jianping; Xin, Hualei] Qingdao Inst Prevent Med, Qingdao, Peoples R China.
   [Sun, Xiufen] Qingdao Shinan Municipal Ctr Dis Control & Preven, Qingdao, Peoples R China.
   [Ke, Ma] Shandong Univ Tradit Chinese Med, Coll Tradit Chinese Med, Jinan, Shandong, Peoples R China.
   [Yasmeen, Nafeesa] Agr Univ Faisalabad Pakistan, Inst Microbiol, Bahawalpur, Pakistan.
   [Khan, Jamal Muhammad] Islamia Univ Bahawalpur, Univ Coll Vet & Anim Sci, Dept Pathobiol, Bahawalpur, Pakistan.
   [Xue, Shouyong] Qingdao Shibei Municipal Ctr Dis Control & Preven, Qingdao, Peoples R China.
   [Baloch, Zulqarnain] South China Agr Univ, Coll Vet Med, Guangzhou, Guangdong, Peoples R China.
C3 Shandong University of Traditional Chinese Medicine; Islamia University
   of Bahawalpur; South China Agricultural University
RP Xue, SY (corresponding author), Qingdao Shibei Municipal Ctr Dis Control & Preven, Qingdao, Peoples R China.; Baloch, Z (corresponding author), South China Agr Univ, Coll Vet Med, Guangzhou, Guangdong, Peoples R China.
EM sbjkxue@163.com; znbalooch@yahoo.com
RI Sun, Jian-Ping/G-9986-2011; baloch, Dr. Zulqarnain/A-8455-2017
OI Yasmeen, Nafeesa/0000-0003-1731-6557; Yasmeen,
   Nafeesa/0000-0002-7194-6026; baloch, Dr. Zulqarnain/0000-0002-7873-1343
FU Bayer Healthcare in China; World Diabetes Foundation [WDF07-308]
FX This study was funded by the Bayer Healthcare in China and World
   Diabetes Foundation [WDF07-308].
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NR 54
TC 20
Z9 20
U1 0
U2 17
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD OCT 10
PY 2018
VL 9
AR 549
DI 10.3389/fendo.2018.00549
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism
GA GW4EM
UT WOS:000446863800001
PM 30364162
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Brostedt, EM
   de Faire, U
   Westerholm, P
   Knutsson, A
   Alfredsson, L
AF Brostedt, EM
   de Faire, U
   Westerholm, P
   Knutsson, A
   Alfredsson, L
TI Job strain and plasminogen activator inhibitor-1: results from the
   Swedish WOLF study
SO INTERNATIONAL ARCHIVES OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH
LA English
DT Article
DE plasminogen activator inhibitor-1; work; psychological stress;
   cardiovascular disease; risk factors
ID CARDIOVASCULAR RISK-FACTORS; CORONARY-HEART-DISEASE; DECISION LATITUDE;
   MYOCARDIAL-INFARCTION; WORKING MEN; STOCKHOLM; DEMANDS; PLASMA; WOMEN
AB Objectives. To investigate the association between job strain and elevated levels of plasminogen activator inhibitor-1. Methods. A cross-sectional study was carried out, comprising 1,954 actively working men and women between the ages of 19-64 years. Data were collected by questionnaire, clinical examination and blood samples. Results. Elevated plasminogen activator inhibitor-1 levels were more commonly noted in women exposed to job strain than in unexposed women (odds ratio 1.33; 95% confidence interval 1.06-1.65). This association remained after we had adjusted for factors related to behaviour and general health, but became close to 1 after we had adjusted for factors related to the metabolic syndrome. For men, no association between job strain and elevated levels of plasminogen activator inhibitor-1 was observed (odds ratio 0.94; 95% confidence interval 0.71-1.26). Conclusions. Women exposed to job strain were more inclined to respond with increased plasminogen activator inhibitor-1 than men. In this first study on the association between job strain and plasminogen activator inhibitor-1 in both men and women, we observed such a relationship among women but not among men. The data support the notion that job strain might affect the risk of coronary heart disease by influencing an important cardiovascular system: the metabolic syndrome.
C1 NIMH, Sect Dev Genet Epidemiol, Mood & Anxiety Disorders Program, NIH, Bethesda, MD 20892 USA.
   Karolinska Inst, Div Cardiovasc Med, Inst Environm Med, Stockholm, Sweden.
   Karolinska Inst, Dept Med Epidemiol, Stockholm, Sweden.
   Karolinska Hosp, Dept Cardiovasc Med, S-10401 Stockholm, Sweden.
   Natl Inst Working Life, Stockholm, Sweden.
   Umea Univ Hosp, Dept Publ Hlth & Clin Med, S-90185 Umea, Sweden.
C3 National Institutes of Health (NIH) - USA; NIH National Institute of
   Mental Health (NIMH); Karolinska Institutet; Karolinska Institutet;
   Karolinska Institutet; Karolinska University Hospital; Umea University;
   Umea University Hospital
RP Brostedt, EM (corresponding author), NIMH, Sect Dev Genet Epidemiol, Mood & Anxiety Disorders Program, NIH, 15 K N Dr,MSC 2670, Bethesda, MD 20892 USA.
EM ericabrostedt@mail.nih.gov
RI Alfredsson, Lars/AAC-9007-2019
OI Alfredsson, Lars/0000-0003-1688-6697
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NR 15
TC 3
Z9 6
U1 0
U2 3
PU SPRINGER
PI NEW YORK
PA 233 SPRING STREET, NEW YORK, NY 10013 USA
SN 0340-0131
J9 INT ARCH OCC ENV HEA
JI Int. Arch. Occup. Environ. Health
PD JUN
PY 2004
VL 77
IS 5
BP 341
EP 344
DI 10.1007/s00420-004-0514-5
PG 4
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA 835VZ
UT WOS:000222514900007
PM 15103467
DA 2025-06-11
ER

PT J
AU Di Francesco, S
   Tenaglia, RL
AF Di Francesco, Simona
   Tenaglia, Raffaele L.
TI Metabolic Syndrome and Aggressive Prostate Cancer at Initial Diagnosis
SO HORMONE AND METABOLIC RESEARCH
LA English
DT Article
DE metabolic syndrome; prostate carcinoma; hormonal therapy
ID INSULIN-RESISTANCE; OXIDATIVE STRESS; RISK; HYPERTENSION; MEN;
   TESTOSTERONE; METAANALYSIS; ASSOCIATION; COMPONENTS; FEATURES
AB Links between metabolic syndrome and prostate cancer after androgen deprivation therapy are emerging. The aim of the research was to investigate the association of metabolic syndrome and aggressive prostate malignancy, at initial diagnosis, without the influence of hormonal treatment. Retrospective analysis of 133 patients with prostate tumor diagnosis between 2007 and 2009 was conducted. Patients with prostate cancer were subdivided in 2 groups according to Gleason score: Gleason score > 7 as high-grade prostate tumor (Group 1) and < 7 (Group 2) as low-grade prostate tumor. Metabolic syndrome was defined according to International Diabetes Federation and the American Heart Association/National Heart, Lung, and Blood Institute definition. Metabolic syndrome was significantly associated with aggressive prostate cancer (OR 1.87, p < 0.05) and a reduced risk of low-grade prostate cancer (OR 0.53, p < 0.05) at initial diagnosis, without the influence of endocrine therapy. In our study, patients with metabolic syndrome were more likely to present with more aggressive prostate carcinoma vs. patients without metabolic syndrome. Further research should elucidate these relations in larger samples to confirm these associations and to stabilize future prevention and therapeutic strategies.
C1 [Di Francesco, Simona; Tenaglia, Raffaele L.] G DAnnunzio Univ Chieti Pescara, Dept Med & Oral Sci & Biotechnol, Chieti, Italy.
C3 G d'Annunzio University of Chieti-Pescara
RP Di Francesco, S (corresponding author), G DAnnunzio Univ Chieti Pescara, Dept Med & Oral Sci & Biotechnol, Chieti, Italy.
EM docveronica@gmail.com
RI di francesco, Simona/AAG-3271-2019
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NR 31
TC 9
Z9 9
U1 0
U2 3
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0018-5043
EI 1439-4286
J9 HORM METAB RES
JI Horm. Metab. Res.
PD JUL
PY 2017
VL 49
IS 7
BP 507
EP 509
DI 10.1055/s-0043-109866
PG 3
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA FA0BG
UT WOS:000405095200004
PM 28494504
DA 2025-06-11
ER

PT J
AU Fu, YH
   Feng, SH
   Xu, YX
   Yang, YJ
   Chen, HB
   He, WF
   Zhu, WE
   Yin, K
   Xue, ZB
   Wei, B
AF Fu, Yonghui
   Feng, Shenghui
   Xu, Yingxiang
   Yang, Yuanjian
   Chen, Haibo
   He, Wenfeng
   Zhu, Wengen
   Yin, Kang
   Xue, Zhengbiao
   Wei, Bo
TI Association of Depression, Antidepressants With Atrial Fibrillation
   Risk: A Systemic Review and Meta-Analysis
SO FRONTIERS IN CARDIOVASCULAR MEDICINE
LA English
DT Review
DE atrial fibrillation; depression; antidepressants; risk factor;
   meta-analysis
ID METABOLIC SYNDROME; CIGARETTE-SMOKING; IMMUNE-SYSTEM; INFLAMMATION;
   STROKE; HEART; MANAGEMENT; ANXIETY
AB Background: Depression is a possible influence factor for the increased risk of incident atrial fibrillation (AF). Although several investigations have assessed their association, the results are still controversial. Therefore, we conducted a meta-analysis to evaluate the association between depression or using antidepressants and AF. Methods: We systemically performed the literature retrieval from two electronic databases PubMed and EMBASE until March 2022 to extract relevant data. The hazard ratios (HRs) and odds ratios (OR) from included studies with 95% confidence intervals (CIs) were adjusted into the risk ratio (RR) and pooled by using the random-effects model. Results: Totally 9 studies about the associations between depression or antidepressants and incident AF risk were included in this meta-analysis. Among them, 5 studies specifically analyzed the impact of antidepressants on the risk of AF. The outcomes of our analysis indicated that depression or depressive symptoms could increase AF risk (RR = 1.15, 95% CI, 1.03-1.27, P < 0.01). In addition, the use of antidepressants can also increase AF risk (RR = 1.16, 95% CI, 1.07-1.25, P < 0.001). These results remained unchanged when we remove the source of heterogeneity or adjust the analysis model into the fixed-effects model. Conclusions: Based on existing investigations, both depression and the use of antidepressants are closely related to the increase of incident AF risk.
C1 [Fu, Yonghui; Xu, Yingxiang; Yang, Yuanjian; Chen, Haibo; Wei, Bo] Nanchang Univ, Jiangxi Mental Hosp, Dept Psychiat, Affiliated Mental Hosp, Nanchang, Peoples R China.
   [Fu, Yonghui; Xu, Yingxiang; Yang, Yuanjian; Chen, Haibo; Wei, Bo] Jiangxi Prov Clin Res Ctr Mental Disorders, Nanchang, Peoples R China.
   [Feng, Shenghui] Nanchang Univ, Dept Med, Queen Mary Sch, Nanchang, Peoples R China.
   [He, Wenfeng] Nanchang Univ, Jiangxi Key Lab Mol Med, Affiliated Hosp 2, Nanchang, Peoples R China.
   [Zhu, Wengen] Sun Yat Sen Univ, Dept Cardiol, Affiliated Hosp 1, Guangzhou, Peoples R China.
   [Yin, Kang; Xue, Zhengbiao] Gannan Med Univ, Dept Critial Care Med, Affiliated Hosp 1, Ganzhou, Peoples R China.
C3 Nanchang University; Nanchang University; Nanchang University; Sun Yat
   Sen University; Gannan Medical University
RP Wei, B (corresponding author), Nanchang Univ, Jiangxi Mental Hosp, Dept Psychiat, Affiliated Mental Hosp, Nanchang, Peoples R China.; Wei, B (corresponding author), Jiangxi Prov Clin Res Ctr Mental Disorders, Nanchang, Peoples R China.; Xue, ZB (corresponding author), Gannan Med Univ, Dept Critial Care Med, Affiliated Hosp 1, Ganzhou, Peoples R China.
EM 57438440@qq.com; wbjxmh@163.com
RI Yang, Yuan-Jian/AAR-2465-2021; Feng, Shenghui/HKO-7953-2023; Chen,
   Haibo/AAA-3330-2019; Zhu, Wen/KIA-0726-2024
OI Zhu, Wengen/0000-0002-1280-0158; Yang, Yuan-jian/0000-0002-0175-5646
FU National Natural Science Foundation of China [31960146]; Special fund
   for postgraduate innovation in Jiangxi Province [YC2012-B011]
FX Funding This study was supported by the National Natural Science
   Foundation of China [No. 31960146] and Special fund for postgraduate
   innovation in Jiangxi Province (YC2012-B011).
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NR 50
TC 9
Z9 9
U1 2
U2 13
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2297-055X
J9 FRONT CARDIOVASC MED
JI Front. Cardiovasc. Med.
PD MAY 11
PY 2022
VL 9
AR 897622
DI 10.3389/fcvm.2022.897622
PG 8
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 1S2QJ
UT WOS:000803900600001
PM 35647056
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Guo, DY
   Zhang, AD
   Zou, TY
   Ding, R
   Chen, KL
   Pan, Y
   Ji, PL
   Ye, B
   Xiang, ML
AF Guo, Dongye
   Zhang, Andi
   Zou, Tianyuan
   Ding, Rui
   Chen, Kaili
   Pan, Yi
   Ji, Peilin
   Ye, Bin
   Xiang, Mingliang
TI The influence of metabolic syndrome on age-related hearing loss from the
   perspective of mitochondrial dysfunction
SO FRONTIERS IN AGING NEUROSCIENCE
LA English
DT Review
DE age-related hearing loss; metabolic syndrome; mitochondrial dysfunction;
   cochlea; mitochondria
ID APOLIPOPROTEIN-E; DIABETES-MELLITUS; OXIDATIVE STRESS; MOUSE MODEL;
   ASSOCIATION; HYPERTENSION; SIRT1; MECHANISMS; SIRTUINS; OBESITY
AB With the increase in life expectancy in the global population, aging societies have emerged in many countries, including China. As a common sensory defect in the elderly population, the prevalence of age-related hearing loss and its influence on society are increasing yearly. Metabolic syndrome is currently one of the main health problems in the world. Many studies have demonstrated that metabolic syndrome and its components are correlated with a variety of age-related diseases of the peripheral sensory system, including age-related hearing loss. Both age-related hearing loss and metabolic syndrome are high-prevalence chronic diseases, and many people suffer from both at the same time. In recent years, more and more studies have found that mitochondrial dysfunction occurs in both metabolic syndrome and age-related hearing loss. Therefore, to better understand the impact of metabolic syndrome on age-related hearing loss from the perspective of mitochondrial dysfunction, we reviewed the literature related to the relationship between age-related hearing loss and metabolic syndrome and their components to discern the possible role of mitochondria in both conditions.
C1 [Guo, Dongye; Zhang, Andi; Zou, Tianyuan; Ding, Rui; Chen, Kaili; Pan, Yi; Ji, Peilin; Ye, Bin; Xiang, Mingliang] Shanghai Jiao Tong Univ, Ruijin Hosp, Dept Otolaryngol & Head & Neck Surg, Sch Med, Shanghai, Peoples R China.
   [Guo, Dongye; Zhang, Andi; Zou, Tianyuan; Ding, Rui; Chen, Kaili; Pan, Yi; Ji, Peilin; Ye, Bin; Xiang, Mingliang] Shanghai Jiao Tong Univ, Ear Inst, Sch Med, Shanghai, Peoples R China.
   [Guo, Dongye; Zhang, Andi; Zou, Tianyuan; Ding, Rui; Chen, Kaili; Pan, Yi; Ji, Peilin; Ye, Bin; Xiang, Mingliang] Shanghai Key Lab Translat Med Ear & Nose Dis, Shanghai, Peoples R China.
C3 Shanghai Jiao Tong University; Shanghai Jiao Tong University
RP Ye, B; Xiang, ML (corresponding author), Shanghai Jiao Tong Univ, Ruijin Hosp, Dept Otolaryngol & Head & Neck Surg, Sch Med, Shanghai, Peoples R China.; Ye, B; Xiang, ML (corresponding author), Shanghai Jiao Tong Univ, Ear Inst, Sch Med, Shanghai, Peoples R China.; Ye, B; Xiang, ML (corresponding author), Shanghai Key Lab Translat Med Ear & Nose Dis, Shanghai, Peoples R China.
EM aydyebin@126.com; mingliangxiang@163.com
RI DING, RUI/P-3018-2019; Pan, Yixin/MAH-3128-2025
FU Cultivation Project of the Major Research Plan of the National Natural
   Science Foundation of China; National Natural Science Foundation of
   China; Science and Technology Commission of Shanghai Municipality;
   Shanghai Sailing Program; Ruijin Youth NSFC Cultivation Fund; 
   [91949119];  [82101212];  [82101209];  [21ZR1440200];  [20YF1426400]; 
   [19YF1430300]
FX Funding The study was supported by grants from the Cultivation Project
   of the Major Research Plan of the National Natural Science Foundation of
   China (Grant No. 91949119), National Natural Science Foundation of China
   (Grant Nos. 82101212 and 82101209), Science and Technology Commission of
   Shanghai Municipality (Grant No. 21ZR1440200), Shanghai Sailing Program
   (Grant Nos. 20YF1426400 and 19YF1430300), and Ruijin Youth NSFC
   Cultivation Fund.
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NR 103
TC 6
Z9 6
U1 5
U2 33
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1663-4365
J9 FRONT AGING NEUROSCI
JI Front. Aging Neurosci.
PD JUL 29
PY 2022
VL 14
AR 930105
DI 10.3389/fnagi.2022.930105
PG 15
WC Geriatrics & Gerontology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology; Neurosciences & Neurology
GA 4Y1PY
UT WOS:000861305500001
PM 35966796
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU McIntyre, RS
   Danilewitz, M
   Liauw, SS
   Kemp, DE
   Nguyen, HTT
   Kahn, LS
   Kucyi, A
   Soczynska, JK
   Woldeyohannes, HO
   Lachowski, A
   Kim, B
   Nathanson, J
   Alsuwaidan, M
   Taylor, VH
AF McIntyre, Roger S.
   Danilewitz, Marlon
   Liauw, Samantha S.
   Kemp, David E.
   Nguyen, Ha T. T.
   Kahn, Linda S.
   Kucyi, Aaron
   Soczynska, Joanna K.
   Woldeyohannes, Hanna O.
   Lachowski, Angela
   Kim, Byungsu
   Nathanson, Jay
   Alsuwaidan, Mohammad
   Taylor, Valerie H.
TI Bipolar disorder and metabolic syndrome: An international perspective
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Bipolar disorder; Metabolic syndrome
ID CATIE SCHIZOPHRENIA TRIAL; CLINICAL ANTIPSYCHOTIC TRIALS; CARDIOVASCULAR
   RISK-FACTORS; CROSS-SECTIONAL ASSESSMENT; 3RD NATIONAL-HEALTH; EXCESS
   MORTALITY; I DISORDER; PREVALENCE; CARE; INTERVENTION
AB Introduction: The ubiquity and hazards posed by abnormal body composition and metabolic parameters in the bipolar population are a priority research and clinical issue. Herein, we summarize and synthesize international studies describing the rate of US National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III [ATP III])- and International Diabetes Federation (IDF)-defined metabolic syndrome and its criterion components in individuals with bipolar disorder.
   Methods: We conducted a PubMed search of all English-language articles published between January 2005 and July 2009 with the following search terms: metabolic syndrome and bipolar disorder, mania and manic-depression. Articles selected for review were based on adequacy of sample size, the use of standardized experimental procedures, validated assessment measures, and overall manuscript quality.
   Results: The rate of metabolic syndrome in individuals with bipolar disorder is increased relative to the general population. Disparate estimates are reported ranging from comparability to approximately twofold greater than the general population. The increased hazard for metabolic syndrome amongst bipolar individuals is now documented in twelve countries from Europe, Australia, Asia, North and South America. The co-occurrence of metabolic syndrome in the bipolar population is associated with a more complex illness presentation, less favourable response to treatment, and adverse course and outcome. The association between metabolic syndrome and bipolar disorder is mediated/moderated by both iatrogenic and non-iatrogenic factors.
   Discussion: The increased hazard for metabolic syndrome in bipolar populations is due to the clustering of traditional (and emerging) risk factors as well as iatrogenic and health systems factors. Extant data support recommendations for prioritizing, surveillance, prevention, diagnosis and management of metabolic syndrome as routine care of the bipolar patient. (C) 2010 Elsevier B.V. All rights reserved.
C1 [McIntyre, Roger S.; Nathanson, Jay; Alsuwaidan, Mohammad] Univ Toronto, Dept Psychiat, Toronto, ON M5T 2S8, Canada.
   [McIntyre, Roger S.] Univ Toronto, Dept Pharmacol, Toronto, ON M5T 2S8, Canada.
   [McIntyre, Roger S.; Danilewitz, Marlon; Liauw, Samantha S.; Nguyen, Ha T. T.; Kucyi, Aaron; Soczynska, Joanna K.; Woldeyohannes, Hanna O.; Lachowski, Angela; Nathanson, Jay; Alsuwaidan, Mohammad] Univ Hlth Network, Mood Disorders Psychopharmacol Unit, Toronto, ON M5T 2S8, Canada.
   [McIntyre, Roger S.; Soczynska, Joanna K.] Univ Toronto, Inst Med Sci, Toronto, ON M5T 2S8, Canada.
   [Danilewitz, Marlon] Yeshiva Univ, New York, NY 10033 USA.
   [Liauw, Samantha S.] McGill Univ, Montreal, PQ, Canada.
   [Kemp, David E.] Case Western Reserve Univ, Mood & Metab Clin, Univ Hosp, Case Med Ctr, Cleveland, OH 44106 USA.
   [Kahn, Linda S.] SUNY Buffalo, Buffalo, NY 14260 USA.
   [Kim, Byungsu] Univ Ulsan, Coll Med, Dept Psychiat, Seoul, South Korea.
   [Kim, Byungsu] Univ Ulsan, Coll Med, Hlth Promot Ctr, Asan Med Ctr, Seoul, South Korea.
   [Taylor, Valerie H.] McMaster Univ, Dept Psychiat, Hamilton, ON L8S 4L8, Canada.
C3 University of Toronto; University of Toronto; University of Toronto;
   University Health Network Toronto; University of Toronto; Yeshiva
   University; McGill University; University Hospitals of Cleveland;
   University System of Ohio; Case Western Reserve University; State
   University of New York (SUNY) System; University at Buffalo, SUNY;
   University of Ulsan; University of Ulsan; Asan Medical Center; McMaster
   University
RP McIntyre, RS (corresponding author), Univ Toronto, Dept Psychiat, 399 Bathurst St, Toronto, ON M5T 2S8, Canada.
EM roger.mcintyre@uhn.on.ca
RI Kim, Byungsu/JNE-3151-2023; Taylor, Valerie/H-6242-2015; McIntyre,
   Roger/AAU-1000-2020; Kucyi, Aaron/AGI-1442-2022
OI Alsuwaidan, Mohammad/0000-0003-1344-2935; Kucyi,
   Aaron/0000-0001-6707-0028; Soczynska, Joanna/0000-0003-0003-7164;
   Taylor, Valerie/0000-0002-8948-638X
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NR 62
TC 162
Z9 176
U1 0
U2 27
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD NOV
PY 2010
VL 126
IS 3
BP 366
EP 387
DI 10.1016/j.jad.2010.04.012
PG 22
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA 676HJ
UT WOS:000283901300004
PM 20541810
DA 2025-06-11
ER

PT J
AU Karaman, ME
   Arslan, C
   Gursu, MF
AF Karaman, Muhammed Emre
   Arslan, Cengiz
   Gursu, Mehmet Ferit
TI Effects of different exercise loads on serum betatrophin
   (ANGPTL-8/lipasin) and cartonectin (CTRP-3) levels in metabolic syndrome
SO TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
LA English
DT Article
DE aerobic exercise; anaerobic exercise; betatrophin (ANGPL-8); cartonectin
   (CTRP-3); metabolic syndrome; aerobik egzersiz; anaerobik egzersiz;
   betatrofin (ANGPL-8); kartonektin (CTRP-3); metabolik sendrom
ID RESISTANCE EXERCISE; OXIDATIVE STRESS; PROGRAM
AB Objectives The number of studies examining the circulating level change of betatrophin and cartonectin in metabolic syndrome applying different loads of exercise is limited. The purpose of the present study was to investigate how different loads of exercises regulate the betatrophin and cartonectin levels in metabolic syndrome induced rats. Methods A total of 24 Wistar-Albino male rats were used in the study. Rats were divided into four groups as follows; G1: control group (fed with standard diet and tap water), G2: metabolic syndrome group (without exercise application), G3: metabolic syndrome + aerobic exercise group (aerobic exercise applied), G4: metabolic syndrome + anaerobic exercise group (anaerobic exercise applied). Betatrophin and Cartonectin levels were determined by ELISA method in serum samples. Results There was a statistically significant difference in betatrophin levels between the groups and this differentiation was caused by G2 (p <0.05). Cartonectin levels were not significantly different between groups (p> 0.05). Conclusions It can be concluded that anaerobic exercises have more positive effects on glucose balance in metabolic syndrome than aerobic exercises, and by regulating betatrophin levels, anaerobic exercises indicate this effect.
C1 [Karaman, Muhammed Emre] Firat Univ, Fac Sport Sci, Dept Movement & Training, Elazig, Turkey.
   [Arslan, Cengiz] Firat Univ, Fac Sport Sci, Dept Sport & Hlth, Elazig, Turkey.
   [Gursu, Mehmet Ferit] Firat Univ, Dept Med Biochem, Fac Med, Elazig, Turkey.
C3 Firat University; Firat University; Firat University
RP Karaman, ME (corresponding author), Firat Univ, Fac Sport Sci, Dept Movement & Training, Elazig, Turkey.
EM mekaraman@firat.edu.tr
RI KARAMAN, Muhammed Emre/W-4999-2018; GÜRSU, MEHMET/HJZ-1663-2023; GURSU,
   M.Ferit/V-6898-2017; ARSLAN, CENGIZ/O-7448-2018
OI KARAMAN, Muhammed Emre/0000-0003-0800-8093; GURSU,
   M.Ferit/0000-0003-3552-7315; ARSLAN, CENGIZ/0000-0003-4406-1131
CR Abu-Farha M, 2016, CARDIOVASC DIABETOL, V15, DOI 10.1186/s12933-016-0346-0
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NR 34
TC 3
Z9 3
U1 3
U2 16
PU WALTER DE GRUYTER GMBH
PI BERLIN
PA GENTHINER STRASSE 13, D-10785 BERLIN, GERMANY
SN 0250-4685
EI 1303-829X
J9 TURK J BIOCHEM
JI Turk. J. Biochem.
PD MAR 8
PY 2022
VL 47
IS 1
BP 71
EP 78
DI 10.1515/tjb-2021-0120
EA DEC 2021
PG 8
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA ZP6CU
UT WOS:000734474800001
OA gold
DA 2025-06-11
ER

PT J
AU Seet, RCS
   Lee, CYJ
   Lim, ECH
   Quek, AML
   Huang, SH
   Khoo, CM
   Halliwell, B
AF Seet, Raymond C. -S.
   Lee, Chung-Yung J.
   Lim, Erle C. H.
   Quek, Amy M. L.
   Huang, Shan-Hong
   Khoo, Chin-Meng
   Halliwell, Barry
TI Markers of Oxidative Damage Are Not Elevated in Otherwise Healthy
   Individuals With the Metabolic Syndrome
SO DIABETES CARE
LA English
DT Article
ID INSULIN-RESISTANCE; STRESS; ASSOCIATION; QUANTIFICATION; POPULATION;
   PRODUCTS; GLUCOSE
AB OBJECTIVE - The role of oxidative damage in the pathogenesis of metabolic syndrome is poorly understood.
   RESEARCH DESIGN AND METHODS - A detailed cross-sectional study was performed to assess the relationship between lipid oxidation products, gamma-glutamyltransferase, high-sensitivity C-reactive protein (hs-CRP), and phospholipase activities with respect to the metabolic status in a cohort of otherwise healthy individuals.
   RESULTS - A total of 179 individuals (87 men and 92 women) aged 43 +/- 14 years (mean +/- SD) participated in this study. There were no differences in the levels of plasma F-2-isoprostanes, hydroxyeicosatetraenoic acids, cholesterol oxidation products, and phospholipase activities in individuals with features of metabolic syndrome. In multivariate analyses, serum hs-CRP was a consistent independent predictor of metabolic syndrome.
   CONCLUSIONS - Minimal changes were observed in multiple markers of oxidative damage in a well-characterized cohort of individuals with features of metabolic syndrome.
C1 [Seet, Raymond C. -S.; Lee, Chung-Yung J.; Lim, Erle C. H.; Khoo, Chin-Meng] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Med, Singapore 117595, Singapore.
   [Seet, Raymond C. -S.; Lim, Erle C. H.; Quek, Amy M. L.; Khoo, Chin-Meng] Natl Univ Singapore Hosp, Dept Med, Singapore, Singapore.
   [Huang, Shan-Hong; Halliwell, Barry] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Biochem, Singapore 117595, Singapore.
C3 National University of Singapore; National University of Singapore;
   National University of Singapore
RP Seet, RCS (corresponding author), Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Med, Singapore 117595, Singapore.
EM raymond_seet@nus.edu.sg
RI Lee, Jetty Chung-Yung/E-1475-2011; Halliwell, Barry/C-8318-2009; Seet,
   Raymond/KUD-7248-2024; Khoo, Chin Meng/AAD-8790-2022
OI Seet, Raymond/0000-0001-8946-3578; Quek, Amy/0000-0002-0569-0472;
   Halliwell, Barry/0000-0002-3560-7123; Lee, Jetty
   Chung-Yung/0000-0002-8175-7069
FU Biomedical Research Council [03/1/21/18/213]; National Medical Research
   Council [NMRC/1157/2008]
FX This study was supported by the Biomedical Research Council (grant
   03/1/21/18/213) and the National Medical Research Council (grant
   NMRC/1157/2008).
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NR 15
TC 22
Z9 22
U1 0
U2 0
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0149-5992
J9 DIABETES CARE
JI Diabetes Care
PD MAY
PY 2010
VL 33
IS 5
BP 1140
EP 1142
DI 10.2337/dc09-2124
PG 3
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 595RV
UT WOS:000277631200038
PM 20185735
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Alfaifi, AA
   Althemery, AU
AF Alfaifi, Abdullah A.
   Althemery, Abdullah U.
TI Sociodemographic characteristics and health-related quality of life of
   individuals undergoing antidepressant therapy
SO SCIENTIFIC REPORTS
LA English
DT Article
ID METABOLIC SYNDROME; MENTAL-HEALTH; DISORDERS; DEPRESSION; PREVALENCE;
   ILLNESS
AB An important factor for averting depression and creating awareness about clinical treatment is patient preference. Therefore, investigating health-related quality of life associated with different antidepressants is necessary. A retrospective cohort study was performed using the 2018 Medical Expenditure Panel Survey. The MEPS is a nationally representative database of the civilian and noninstitutionalized population spanning different ages, both sexes, and a wide range of sociodemographic and economic backgrounds. Differences in clinical and sociodemographic characteristics among patients using different antidepressant classes were explored. The differences in Veterans RAND 12-Item Health Survey (VR-12) results among groups were examined. The VR-12 metric was used since it measures a patient's overall perspective of their health. Approximately 34.6 million of the patients reported using at least one antidepressant during 2018. Most patients receiving tricyclic therapy reported substantially better mental HRQoL than patients receiving selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), or combination therapy. Patients receiving atypical antidepressants reported substantially better mental HRQoL than those receiving other types of antidepressants. Most patients reported a substantial decline in HRQoL after SNRIs or combination therapy. This study found that HRQoL varied across antidepressant users. Thus, health care providers could benefit from taking into consideration quality of life when prescribing antidepressant agents. Moreover, further research is needed to explore other factors that could contribute to the quality of care for patients with depression.
C1 [Alfaifi, Abdullah A.; Althemery, Abdullah U.] Prince Sattam Bin Abdulaziz Univ, Coll Pharm, Dept Clin Pharm, Al Kharj 11942, Saudi Arabia.
C3 Prince Sattam Bin Abdulaziz University
RP Alfaifi, AA (corresponding author), Prince Sattam Bin Abdulaziz Univ, Coll Pharm, Dept Clin Pharm, Al Kharj 11942, Saudi Arabia.
EM a.alfaifi@psau.edu.sa
RI Alfaifi, Abdullah/GQP-7570-2022; Althemery, Abdullah/GRJ-9563-2022
OI Althemery, Abdullah/0000-0002-3415-7685; Alfaifi,
   Abdullah/0000-0002-6122-138X
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NR 34
TC 2
Z9 2
U1 0
U2 3
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD OCT 20
PY 2022
VL 12
IS 1
AR 17518
DI 10.1038/s41598-022-22164-6
PG 8
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 5M0UD
UT WOS:000870820900016
PM 36266422
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Haefner, S
   Baghai, TC
   Schule, C
   Eser, D
   Spraul, M
   Zill, P
   Rupprecht, R
   Bondy, B
AF Haefner, S.
   Baghai, T. C.
   Schule, C.
   Eser, D.
   Spraul, M.
   Zill, P.
   Rupprecht, R.
   Bondy, B.
TI Impact of Gene-Gender Effects of Adrenergic Polymorphisms on
   Hypothalamic-Pituitary-Adrenal Axis Activity in Depressed Patients
SO NEUROPSYCHOBIOLOGY
LA English
DT Article
DE Depression; Dexamethasone suppression test; HPA axis; Adrenoreceptors;
   Genetic polymorphism; Gene-gender effects
ID CORONARY-ARTERY-DISEASE; RECEPTOR POLYMORPHISMS; METABOLIC SYNDROME;
   MAJOR DEPRESSION; STRESS; OBESITY; SEROTONIN; NOREPINEPHRINE;
   ASSOCIATION; RESPONSES
AB Objective: There is overwhelming evidence that activation of the hypothalamic-pituitary-adrenal (HPA) system plays a major role in depression and cardiovascular disease in genetically susceptible individuals. We hypothesized that due to the multiple interactions between the sympathetic and the HPA systems via adrenoceptors, polymorphisms in these genes could have an impact on HPA axis activity in major depression. Methods: Using the dexamethasone/corticotrophin-releasing hormone (DEX/CRH) test, we investigated the association of alpha 2-adrenoceptor (ADRA2A -1291C -> G) and the beta 2-adrenoceptor gene (ADRB2 Arg16Gly) in 189 patients with major depression during the acute state of the disease and after remission. Results: Male ADRA2A -1291G allele homozygotes showed significant pretreatment HPA axis hyperactivity, with increased adrenocorticotropin (ACTH; F = 4.9, d.f. = 2, p = 0.009) and cortisol responses (F = 6.4, d.f. = 2, p = 0.003). In contrast, female ADRB2 Arg/Arg homozygotes had increased pretreatment ACTH (F = 7.17, d.f. = 2, p = 0.001) and cortisol (F = 8.95, d.f. = 2, p = 0.000) levels. Interestingly, in the respective genotypes, the stress hormones remained elevated in the second DEX/CRH test, despite a reduction in depressive symptoms. Conclusions: This study provides evidence that, depending on gender and polymorphisms, there is continuous HPA axis overdrive in a proportion of patients irrespective of the status of depression. Considering the importance of stress hormones for cardiovascular disorders, our data might suggest that these patients are at high risk of comorbidity between depression and cardiovascular disorders. Copyright (c) 2008 S. Karger AG, Basel
C1 [Haefner, S.; Baghai, T. C.; Schule, C.; Eser, D.; Spraul, M.; Zill, P.; Rupprecht, R.; Bondy, B.] Univ Munich, Dept Psychiat & Psychotherapy, DE-80336 Munich, Germany.
C3 University of Munich
RP Bondy, B (corresponding author), Univ Munich, Dept Psychiat & Psychotherapy, Nussbaumstr 7, DE-80336 Munich, Germany.
EM brigitta.bondy@med.uni-muenchen.de
OI Baghai, Thomas C/0000-0002-7873-4130
FU German Federal Research Ministry
FX The results presented in this paper are part of the doctoral thesis of
   M. S. Part of this work was supported by a grant from the German Federal
   Research Ministry within the promotional emphasis 'Competence Nets in
   Medicine'.
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NR 29
TC 15
Z9 17
U1 0
U2 3
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0302-282X
EI 1423-0224
J9 NEUROPSYCHOBIOLOGY
JI Neuropsychobiology
PY 2008
VL 58
IS 3-4
BP 154
EP 162
DI 10.1159/000182891
PG 9
WC Neurosciences; Psychiatry; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Psychiatry; Psychology
GA 412TR
UT WOS:000263747600006
PM 19088492
OA Green Published
DA 2025-06-11
ER

PT J
AU Palasciano, G
   Moschetta, A
   Palmieri, VO
   Grattagliano, I
   Iacobellis, G
   Portincasa, P
AF Palasciano, Giuseppe
   Moschetta, Antonio
   Palmieri, Vincenzo O.
   Grattagliano, Ignazio
   Iacobellis, Gianluca
   Portincasa, Piero
TI Non-alcoholic fatty liver disease in the metabolic syndrome
SO CURRENT PHARMACEUTICAL DESIGN
LA English
DT Review
DE metabolic syndrome; non-alcoholic fatty liver disease; non-alcoholic
   steatohepatitis; breath test
ID C-13-METHACETIN BREATH TEST; LIFE-STYLE MODIFICATION; URSODEOXYCHOLIC
   ACID; ALCOHOL-CONSUMPTION; CONTROLLED-TRIAL; PROVISIONAL REPORT; OBESE
   SUBJECTS; RISK-FACTORS; FOLLOW-UP; STEATOHEPATITIS
AB Non-alcoholic fatty liver disease (NAFLD) is often associated with features of the metabolic syndrome, carrying an increased risk to develop non-alcoholic steatohepatitis (NASH), the inflammatory form of liver steatosis. Epidemiological data confirm that obesity. diabetes, hypertension and hyperlipidemia are frequently found in NAFLD and worsen its prognosis because of increased risk of fibrotic evolution, eventually leading to liver cirrhosis. Recent studies confirm the close relationship between the metabolic syndrome and liver steatosis, and further support the detrimental role of oxidative stress and lipid peroxidation, which are pathophysiological processes present in both conditions. Novel diagnostic tools and life style modifications together with targeted therapeutic actions are urgently needed for the management of liver dysfunction in course of metabolic syndrome.
C1 Univ Bari, Policlin Bari, Dept Internal & Publ Hlth, Clin Med A Murri, I-70124 Bari, Italy.
   McMaster Univ, Dept Med Cardiovasc Obes Res & Management, Hamilton, ON, Canada.
C3 Universita degli Studi di Bari Aldo Moro; McMaster University
RP Portincasa, P (corresponding author), Univ Bari, Policlin Bari, Dept Internal & Publ Hlth, Clin Med A Murri, Pzza G Cesare 11, I-70124 Bari, Italy.
EM p.portincasa@semeiotica.uniba.it
RI Moschetta, Antonio/K-6211-2016; portincasa, piero/J-7245-2018
OI palmieri, vincenzo ostilio/0000-0002-7649-6028; Palasciano,
   Giuseppe/0000-0002-0396-488X; Moschetta, Antonio/0000-0003-2123-6074;
   portincasa, piero/0000-0001-5359-1471
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NR 91
TC 41
Z9 44
U1 0
U2 6
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1381-6128
EI 1873-4286
J9 CURR PHARM DESIGN
JI Curr. Pharm. Design
PY 2007
VL 13
IS 21
BP 2193
EP 2198
PG 6
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 193BY
UT WOS:000248249800009
PM 17627552
DA 2025-06-11
ER

PT J
AU Gkousioudi, A
   Yu, XJ
   Ferruzzi, J
   Qian, JC
   Wainford, RD
   Seta, F
   Zhang, YH
AF Gkousioudi, Anastasia
   Yu, Xunjie
   Ferruzzi, Jacopo
   Qian, Juncheng
   Wainford, Richard D.
   Seta, Francesca
   Zhang, Yanhang
TI Biomechanical Properties of Mouse Carotid Arteries With Diet-Induced
   Metabolic Syndrome and Aging
SO FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
LA English
DT Article
DE metabolic syndrome; aging; elastic energy storage; material stiffness;
   biaxial inflation-extension
ID EXTRACELLULAR-MATRIX; CARDIOVASCULAR RISK; HEART-DISEASE; OBESITY;
   STIFFNESS; HYPERTENSION; ELASTIN; MECHANISMS; HEALTH; TISSUE
AB Metabolic syndrome increases the risk of cardiovascular diseases. Arteries gradually stiffen with aging; however, it can be worsened by the presence of conditions associated with metabolic syndrome. In this study, we investigated the combined effects of diet-induced metabolic syndrome and aging on the biomechanical properties of mouse common carotid arteries (CCA). Male mice at 2 months of age were fed a normal or a high fat and high sucrose (HFHS) diet for 2 (young group), 8 (adult group) and 18-20 (old group) months. CCAs were excised and subjected to in vitro biaxial inflation-extension tests and the Cauchy stress-stretch relationships were determined in both the circumferential and longitudinal directions. The elastic energy storage of CCAs was obtained using a four-fiber family constitutive model, while the material stiffness in the circumferential and longitudinal directions was computed. Our study showed that aging is a dominant factor affecting arterial remodeling in the adult and old mice, to a similar extent, with stiffening manifested with a significantly reduced capability of energy storage by similar to 50% (p < 0.05) and decreases in material stiffness and stress (p < 0.05), regardless of diet. On the other hand, high fat high sucrose diet resulted in an accelerated arterial remodeling in the young group at pre-diabetic stage by affecting the circumferential material stiffness and stress (p < 0.05), which was eventually overshadowed by aging progression. These findings have important implications on the effects of metabolic syndrome on elastic arteries in the younger populations.
C1 [Gkousioudi, Anastasia; Yu, Xunjie; Qian, Juncheng; Zhang, Yanhang] Boston Univ, Dept Mech Engn, Boston, MA 02215 USA.
   [Ferruzzi, Jacopo] Univ Texas Dallas, Dept Bioengn, Richardson, TX USA.
   [Wainford, Richard D.] Boston Univ, Whitaker Cardiovasc Inst, Dept Pharmacol & Expt Therapeut, Sch Med, Boston, MA USA.
   [Seta, Francesca] Boston Univ, Whitaker Cardiovasc Inst, Vasc Biol Sect, Sch Med, Boston, MA USA.
   [Zhang, Yanhang] Boston Univ, Div Mat Sci & Engn, Boston, MA 02215 USA.
   [Zhang, Yanhang] Boston Univ, Dept Biomed Engn, Boston, MA 02215 USA.
C3 Boston University; University of Texas System; University of Texas
   Dallas; Boston University; Boston University; Boston University; Boston
   University
RP Zhang, YH (corresponding author), Boston Univ, Dept Mech Engn, Boston, MA 02215 USA.; Zhang, YH (corresponding author), Boston Univ, Div Mat Sci & Engn, Boston, MA 02215 USA.; Zhang, YH (corresponding author), Boston Univ, Dept Biomed Engn, Boston, MA 02215 USA.
EM yanhang@bu.edu
RI Wainford, Richard/ABC-1735-2020; Seta, Francesca/ABB-1566-2020
OI Gkousioudi, Anastasia/0009-0001-1592-683X; Seta,
   Francesca/0000-0001-7985-5615
FU National Institute of Health [2R01HL098028, R01HL136311, R01AG062515];
   National Heart Lung and Blood Institute [R01HL136311] Funding Source:
   NIH RePORTER
FX Funding The authors would like to acknowledge funding support from
   National Institute of Health to YZ (2R01HL098028), FS (R01HL136311), and
   RW (R01AG062515).
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NR 51
TC 7
Z9 11
U1 0
U2 6
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-4185
J9 FRONT BIOENG BIOTECH
JI Front. Bioeng. Biotechnol.
PD MAR 22
PY 2022
VL 10
AR 862996
DI 10.3389/fbioe.2022.862996
PG 10
WC Biotechnology & Applied Microbiology; Engineering, Biomedical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Engineering
GA 0I6HQ
UT WOS:000779520100001
PM 35392404
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Ahmadpanah, M
   Haghighi, M
   Jahangard, L
   Borzoei, S
   Heshmati, S
   Bajoghli, H
   Holsboer-Trachsler, E
   Brand, S
AF Ahmadpanah, Mohammad
   Haghighi, Mohammad
   Jahangard, Leila
   Borzoei, Shiva
   Heshmati, Safora
   Bajoghli, Hafez
   Holsboer-Trachsler, Edith
   Brand, Serge
TI No evidence for metabolic syndrome and lipid profile differences in
   patients suffering from bipolar I disorder with and without suicide
   attempts
SO INTERNATIONAL JOURNAL OF PSYCHIATRY IN CLINICAL PRACTICE
LA English
DT Article
DE Metabolic syndrome; suicide; bipolar disorder; lipid values; fasting
   blood sugar; acute phase
ID LOW SERUM-CHOLESTEROL; MOOD DISORDERS; PSYCHIATRIC COMORBIDITIES; MAJOR
   DEPRESSION; CONTROLLED-TRIAL; BRAIN-INJURY; RISK-FACTORS; BEHAVIOR;
   NONATTEMPTERS; ASSOCIATION
AB Objective. The aim of the present study was to provide further evidence of (1) metabolic syndrome and blood lipid profile differences between suicide attempting and non-attempting patients with bipolar disorder (BPD) I and to assess these differences (2) as a function of acute depressive or manic phase. Methods. Fifty inpatients (mean age: 36.14 years 48% males) with BPD I took part in the study. Aft er recruitment, patients were clustered in four groups: 13 suicide attempters (SAs) assessed during a manic phase, 12 SAs assessed during a depressive phase, 15 non-SAs assessed during a manic phase, and 10 non-SAs assessed during a depressive phase. Body mass index (BMI), metabolic syndrome, blood pressure, blood lipids (cholesterol, high-and low-density lipids, and triglyceride), and fasting blood sugar were assessed. Results. Neither metabolic syndrome, blood lipid values, fasting blood sugar, nor BMI or blood pressure differed between the SAs and non-SAs, or between patients in an acute manic phase and those in a depressed phase. The overall prevalence of metabolic syndrome was 26.0%. Conclusion. Among patients with BPD I neither the occurrence of metabolic syndrome nor lipid values or fasting blood sugar are reliable biomarkers of suicidal behavior during either acute depressive or manic phase.
C1 [Ahmadpanah, Mohammad; Haghighi, Mohammad; Jahangard, Leila] Hamadan Univ Medial Sci, Res Ctr Behav Disorders & Subst Abuse, Hamadan, Iran.
   [Borzoei, Shiva] Hamadan Univ Medial Sci, Dept Endocrinol, Fac Med, Hamadan, Iran.
   [Heshmati, Safora] Hamadan Univ Medial Sci, Dept Psychiat, Fac Med, Hamadan, Iran.
   [Bajoghli, Hafez] Tehran Univ Medial Sci, Iranian Inst Reduct High Risk Behav, Iranian Natl Ctr Addict Studies, Tehran, Iran.
   [Holsboer-Trachsler, Edith; Brand, Serge] Univ Basel, Psychiat Clin Univ Basel, Ctr Affect Stress & Sleep Disorders, CH-4012 Basel, Switzerland.
   [Brand, Serge] Univ Basel, Dept Sport,Exercise & Hlth, Sport Sci Sect, CH-4012 Basel, Switzerland.
C3 University of Basel; University of Basel
RP Brand, S (corresponding author), Univ Basel, Psychiat Clin Univ Basel, Ctr Affect Stress & Sleep Disorders, Wilhelm Klein Str 27, CH-4012 Basel, Switzerland.
EM serge.brand@upkbs.ch
RI Brand, Serge/H-7159-2019; Haghighi, Mohammad/R-3453-2017; Borzouei,
   Shiva/F-6269-2017; ahmadpanah, mohammad/U-6860-2017; Jahangard,
   Leila/R-4159-2017
OI Haghighi, Mohammad/0000-0002-4875-1036; Borzouei,
   Shiva/0000-0001-6826-9872; Brand, Serge/0000-0003-2175-2765; ahmadpanah,
   mohammad/0000-0003-2908-2460; Jahangard, Leila/0000-0002-2834-4644
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NR 60
TC 14
Z9 15
U1 0
U2 4
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1365-1501
EI 1471-1788
J9 INT J PSYCHIAT CLIN
JI Int. J. Psychiat. Clin.
PY 2015
VL 19
IS 3
BP 168
EP 173
DI 10.3109/13651501.2015.1049277
PG 6
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychiatry
GA CR4UH
UT WOS:000361334500003
PM 25969160
DA 2025-06-11
ER

PT J
AU Leisegang, K
   Dutta, S
AF Leisegang, Kristian
   Dutta, Sulagna
TI Do lifestyle practices impede male fertility?
SO ANDROLOGIA
LA English
DT Review; Early Access
DE endocrine disruptors; genital heat stress; male infertility; nutrition
   and obesity; tobacco; alcohol and recreational drugs
ID SEMEN-QUALITY PARAMETERS; SPERM DNA-DAMAGE; BODY-MASS INDEX;
   MALE-INFERTILITY; CIGARETTE-SMOKING; MALE PARTNERS; ENDOCANNABINOID
   SYSTEM; MOLECULAR-MECHANISMS; HUMAN SPERMATOZOA; DIETARY PATTERNS
AB Alongside an increasing prevalence of couple and male infertility, evidence suggests there is a global declining trend in male fertility parameters over the past few decades. This may, at least in part, be explained through detrimental lifestyle practices and exposures. These include alcohol and tobacco consumption, use of recreational drugs (e.g., cannabis, opioids and anabolic steroids), poor nutritional habits, obesity and metabolic syndrome, genital heat stress (e.g., radiation exposure through cell phones and laptops, prolonged periods of sitting, tight-fitting underwear and recurrent hot baths or saunas), exposure to endocrine-disrupting chemicals (e.g., pesticide residue, bisphenol A, phthalates and dioxins) and psychological stress. This review discusses these lifestyle practices and the current evidence associated with male infertility. Furthermore, known mechanisms of action are also discussed for each of these. Common mechanisms associated with a reduction in spermatogenesis and/or steroidogenesis due to unfavourable lifestyle practices include inflammation and oxidative stress locally or systemically. It is recommended that relevant lifestyle practices are investigated in clinical history of male infertility cases, particularly in unexplained or idiopathic male infertility. Appropriate modification of detrimental lifestyle practices is further suggested and recommended in the management of male infertility.
C1 [Leisegang, Kristian] Univ Western Cape, Sch Nat Med, Blanckenberg Rd, Cape Town, South Africa.
   [Dutta, Sulagna] MAHSA Univ, Fac Dent, Dept Oral Biol & Biomed Sci, Jenjarom, Selangor, Malaysia.
C3 University of the Western Cape; Mahsa University
RP Leisegang, K (corresponding author), Univ Western Cape, Sch Nat Med, Blanckenberg Rd, Cape Town, South Africa.
EM kleisegang@uwc.ac.za
RI Leisegang, Kristian/AAS-3925-2021; Dutta, Sulagna/W-5151-2017
OI Dutta, Sulagna/0000-0002-7893-5282; Leisegang,
   Kristian/0000-0002-3003-8048
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NR 130
TC 74
Z9 78
U1 3
U2 33
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0303-4569
EI 1439-0272
J9 ANDROLOGIA
JI Andrologia
PD 2020 APR 24
PY 2020
AR e13595
DI 10.1111/and.13595
EA APR 2020
PG 13
WC Andrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA LG4IR
UT WOS:000528067100002
PM 32330362
OA gold
DA 2025-06-11
ER

PT J
AU Zeman, M
   Vecka, M
   Jachymova, M
   Jirak, R
   Tvrzicka, E
   Stankova, B
   Zak, A
AF Zeman, Miroslav
   Vecka, Marek
   Jachymova, Marie
   Jirak, Roman
   Tvrzicka, Eva
   Stankova, Barbora
   Zak, Ales
TI Fatty Acid CoA Ligase-4 Gene Polymorphism Influences Fatty Acid
   Metabolism in Metabolic Syndrome, but not in Depression
SO TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE
LA English
DT Article
DE Long-chain fatty acid-CoA ligase 4; metabolic syndrome; depression;
   fatty acid; delta-5 fatty acid desaturase
ID INSULIN-RESISTANCE; OXIDATIVE STRESS; SYNTHETASE; CELLS; EPIDEMIOLOGY;
   DESATURATION; SENSITIVITY; PREDICTORS; MECHANISM; SEVERITY
AB The composition of polyunsaturated fatty acids (PUFAs) in cell membranes and body tissues is altered in metabolic syndrome (MetS) and depressive disorder (DID). Within the cell, fatty acid coenzyme A (CoA) ligases (FACLs) activate PUFAs by esterifying with CoA. The FACL4 isoform prefers PUFAs (arachidonic and eicosapentaenoic acid) as substrates, and the FACL4 gene is mapped to Xq23. We have analyzed the association between the common single nucleotide polymorphism (SNP) (rs1324805, C to T substitution) in the first intron of the FACL4 gene and MetS or DID. The study included 113 healthy subjects (54Males/59Females), 56 MetS patients (34M/22F) and 41 DID patients (7M/34F). In MetS group, T-carriers and patients with CC or CO (CC/C0) genotype did not differ in the values of metabolic indices of MetS and M/F ratio. Nevertheless, in comparison with CC/C0, the T-allele carriers were characterized by enhanced unfavorable changes in fatty acid metabolism typical for MetS: higher content of dihomogammalinolenic acid (P < 0.05) and lower content of arachidonic acid in plasma phosphatidylcholine (PC) (P = 0.052), lower index of Delta 5 desaturation (P < 0.01) and unsaturation index (UI) (P < 0.001). In contrast, DID patients had higher concentrations of plasma glucose, insulin, conjugated dienes and index of insulin resistance, but showed no significant association with the studied SNP. The present study shows that the common SNP (C to T substitution) in the first intron of the FACL4 gene is associated with altered FA composition of plasma phosphatidylcholines in patients with MetS.
C1 [Zeman, Miroslav; Vecka, Marek; Tvrzicka, Eva; Stankova, Barbora; Zak, Ales] Charles Univ Prague, Fac Med 1, Dept Internal Med 4, Gen Teaching Hosp Prague, Prague 12808 2, Czech Republic.
   [Jachymova, Marie] Inst Clin Biochem, Prague, Czech Republic.
   [Jachymova, Marie] Diagnost Lab, Prague, Czech Republic.
   [Jirak, Roman] Charles Univ Prague, Fac Med 1, Psychiat Clin, Prague 12808 2, Czech Republic.
C3 General University Hospital Prague; Charles University Prague; Charles
   University Prague
RP Zeman, M (corresponding author), Charles Univ Prague, Fac Med 1, Dept Internal Med 4, Nemocnice 2, Prague 12808 2, Czech Republic.
EM mirozem@centrum.cz
RI Zeman, Miroslav/J-5281-2016; Jirak, Roman/O-1658-2017; Tvrzicka,
   Eva/Q-6300-2016; Vecka, Marek/A-3560-2008; Zak, Ales/G-8318-2016;
   Stankova, Barbora/L-7933-2016
OI Zeman, Miroslav/0000-0001-5338-603X; Jirak, Roman/0000-0002-8061-9668;
   Tvrzicka, Eva/0000-0003-0794-8454; Vecka, Marek/0000-0002-3269-1817;
   Zak, Ales/0000-0002-1698-6068; Stankova, Barbora/0000-0002-6184-4878
FU IGA Ministry of Health of Czech Republic [8806-3]
FX This work was Supported by research grant IGA Ministry of Health of
   Czech Republic, NR 8806-3.
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NR 45
TC 17
Z9 17
U1 0
U2 6
PU TOHOKU UNIV MEDICAL PRESS
PI SENDAI
PA 2-1, SEIRYO-MACHI, AOBA-KU, SENDAI, MIYAGI 980-8575, JAPAN
SN 0040-8727
EI 1349-3329
J9 TOHOKU J EXP MED
JI Tohoku J. Exp. Med.
PD APR
PY 2009
VL 217
IS 4
BP 287
EP 293
DI 10.1620/tjem.217.287
PG 7
WC Medicine, General & Internal; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Research & Experimental Medicine
GA 433IO
UT WOS:000265197700005
PM 19346733
OA Bronze
DA 2025-06-11
ER

PT J
AU Hou, CY
   Tain, YL
   Yu, HR
   Huang, LT
AF Hou, Chih-Yao
   Tain, You-Lin
   Yu, Hong-Ren
   Huang, Li-Tung
TI The Effects of Resveratrol in the Treatment of Metabolic Syndrome
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE resveratrol; metabolic syndrome; high-fat diet; resveratrol derivatives
ID HIGH-FAT DIET; INSULIN-RESISTANCE; OXIDATIVE STRESS; INDUCED
   HYPERTENSION; COGNITIVE FUNCTION; GUT MICROBIOTA; ADIPOSE-TISSUE; SWINE
   MODEL; PREVENTS; DISEASE
AB Resveratrol, also known as 3,5,4-trihydroxystilbene, is a natural polyphenol that occurs as a phytoalexin. It is produced by plant sources such as grapes, apples, blueberries, plums, peanuts, and other oilseeds. This compound has a variety of effects on human health and diseases. This review summarizes the mounting evidence that resveratrol is helpful in treating metabolic syndrome and related disorders. Resveratrol can be provided either early as a reprogramming agent or later as part of treatment. A few of the main mechanisms underlying the beneficial effects of resveratrol on metabolic syndrome are outlined. This review also discusses the potential of resveratrol derivatives as a complementary or alternative medicine. In conclusion, resveratrol could be a useful regimen for the prevention and treatment of metabolic syndrome and its related conditions.
C1 [Hou, Chih-Yao] Natl Kaohsiung Univ Sci & Technol, Dept Seafood Sci, Kaohsiung 811, Taiwan.
   [Tain, You-Lin; Yu, Hong-Ren; Huang, Li-Tung] Kaohsiung Chang Gung Mem Hosp, Inst Translat Res Biomed, Kaohsiung 833, Taiwan.
   [Tain, You-Lin; Yu, Hong-Ren; Huang, Li-Tung] Chang Gung Univ, Coll Med, Kaohsiung 833, Taiwan.
   [Tain, You-Lin; Yu, Hong-Ren] Kaohsiung Chang Gung Mem Hosp, Dept Pediat, Kaohsiung 833, Taiwan.
   [Huang, Li-Tung] Chang Gung Univ, Dept Tradit Med, Linkow 333, Taiwan.
C3 National Kaohsiung University of Science & Technology; Chang Gung
   Memorial Hospital; Chang Gung University; Chang Gung Memorial Hospital
RP Huang, LT (corresponding author), Kaohsiung Chang Gung Mem Hosp, Inst Translat Res Biomed, Kaohsiung 833, Taiwan.; Huang, LT (corresponding author), Chang Gung Univ, Coll Med, Kaohsiung 833, Taiwan.; Huang, LT (corresponding author), Chang Gung Univ, Dept Tradit Med, Linkow 333, Taiwan.
EM chihyaohou@gmail.com; tainyl@hotmail.com; yuu2004taiwan@yahoo.com.tw;
   litung.huang@gmail.com
RI Chih-Yao, Hou/AAH-1803-2020; Tain, You-Lin/H-2827-2019; yu,
   hong-ren/KII-6665-2024; Yu, Hong-Ren/AAW-6827-2021
OI Tain, You-Lin/0000-0002-7059-6407; Hou, Chih-Yao/0000-0002-8007-6077;
   Yu, Hong-Ren/0000-0003-1242-8760
FU Chang Gung Memorial Hospital, Kaohsiung, Taiwan [CMRPG8G0632]
FX This work was supported by Grant CMRPG8G0632 from Chang Gung Memorial
   Hospital, Kaohsiung, Taiwan to L.-T.H.
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NR 92
TC 100
Z9 110
U1 9
U2 36
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD FEB 1
PY 2019
VL 20
IS 3
AR 535
DI 10.3390/ijms20030535
PG 15
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA HQ4WR
UT WOS:000462412500079
PM 30695995
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Yeung, EW
   Place, R
   Gordish-Dressman, H
   Visich, P
   Hoffman, E
   Walker, SO
   Granger, DA
AF Yeung, Ellen W.
   Place, Rebecca
   Gordish-Dressman, Heather
   Visich, Paul
   Hoffman, Eric
   Walker, Sheila O.
   Granger, Douglas A.
TI Salivary latent trait cortisol (LTC): Relation to lipids, blood
   pressure, and body composition in middle childhood
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE Latent trait cortisol (LTC); Middle childhood; Lipids; Body composition;
   Blood pressure; Toxic stress
ID METABOLIC SYNDROME; MISSING-DATA; CARDIOMETABOLIC RISK;
   SOCIOECONOMIC-STATUS; MOMENTARY CORTISOL; STRESS; OBESITY; HYPERTENSION;
   BIOMARKERS; VALIDITY
AB Adversity experienced early in life has the potential to influence physical health later in life. The stress-health relation may be partially explained by stress-related effects on cardiovascular risk factors. This study explored links between individual differences in trait-like variation in the activity of the hypothalamic-pituitary-adrenal (HPA) axis with cardiovascular risk factors in children. 474 children (M age = 9.22 years; 54% female; 83% Caucasian) were included in this study, in which cardiovascular risk was assessed using the following indices - triglycerides (TG), HDL-cholesterol (HDL-C), glucose (Glu); resting systolic and diastolic blood pressure, body mass index (BMI), waist-to-hip ratio, and % fat. Saliva samples were measured 3 times a day (waking, 30 min post-waking and bedtime) over 3 days (later assayed for cortisol). A latent trait cortisol (LTC) factor explained 43% of the variance in cortisol levels within and across days. Confirmatory factor analysis identified three cardiovascular risk factors: lipids (i.e., TG and HDL-C), blood pressure (i.e., systolic and diastolic), and body composition (i.e., BMI, Waist-to-hip ratio, and % fat). Lower salivary LTC was associated with higher lipids, higher blood pressure, and higher body composition. The findings further support the internal and external validity of the LTC construct, and may also advance our understanding of the link between interindividual differences in HPA axis activity and cardiovascular risk in middle childhood. Published by Elsevier Ltd.
C1 [Yeung, Ellen W.; Granger, Douglas A.] Arizona State Univ, Dept Psychol, Tempe, AZ 85287 USA.
   [Place, Rebecca; Visich, Paul] Univ New England, Dept Exercise & Sport Performance, Biddeford, ME 04005 USA.
   [Gordish-Dressman, Heather] George Washington Univ, Sch Med, Childrens Natl Med Ctr, Washington, DC 20010 USA.
   [Hoffman, Eric] Childrens Natl Med Ctr, Med Genet Res Ctr, Washington, DC 20012 USA.
   [Walker, Sheila O.; Granger, Douglas A.] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Baltimore, MD 21205 USA.
   [Walker, Sheila O.] Johns Hopkins Univ, Sch Educ, Baltimore, MD 21218 USA.
   [Granger, Douglas A.] Johns Hopkins Univ, Sch Nursing, Baltimore, MD 21205 USA.
   [Granger, Douglas A.] Johns Hopkins Univ, Sch Med, Baltimore, MD 21218 USA.
   [Yeung, Ellen W.; Walker, Sheila O.; Granger, Douglas A.] Univ Calif Irvine, Inst Interdisciplinary Salivary Biosci Res, Irvine, CA 92697 USA.
C3 Arizona State University; Arizona State University-Tempe; University of
   New England - Maine; Children's National Health System; George
   Washington University; Children's National Health System; Johns Hopkins
   University; Johns Hopkins Bloomberg School of Public Health; Johns
   Hopkins University; Johns Hopkins University; Johns Hopkins University;
   University of California System; University of California Irvine
RP Granger, DA (corresponding author), Univ Calif Irvine, Inst Interdisciplinary Salivary Biosci Res, Irvine, CA 92697 USA.; Yeung, EW (corresponding author), Univ Missouri, Dept Psychol Sci, Columbia, MO 65211 USA.
EM Wan.Yeung@asu.edu
RI Hoffman, Eric/KYP-6390-2024
OI Hoffman, Eric/0000-0001-6470-5139
FU Children's National Medical Center, Washington; Clark Charitable
   Foundation
FX CHIP was supported by a subcontract from the Children's National Medical
   Center, Washington, DC that was funded from The Clark Charitable
   Foundation.
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NR 60
TC 7
Z9 8
U1 0
U2 13
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
EI 1873-3360
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD SEP
PY 2016
VL 71
BP 110
EP 118
DI 10.1016/j.psyneuen.2016.05.013
PG 9
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA DT0GY
UT WOS:000381163000014
PM 27262343
DA 2025-06-11
ER

PT J
AU Camacho-Barcia, L
   Munguía, L
   Lucas, I
   de la Torre, R
   Salas-Salvadó, J
   Pintó, X
   Corella, D
   Granero, R
   Jiménez-Murcia, S
   González-Monje, I
   Esteve-Luque, V
   Cuenca-Royo, A
   Gómez-Martínez, C
   Paz-Graniel, I
   Forcano, L
   Fernández-Aranda, F
AF Camacho-Barcia, Lucia
   Munguia, Lucero
   Lucas, Ignacio
   de la Torre, Rafael
   Salas-Salvado, Jordi
   Pinto, Xavier
   Corella, Dolores
   Granero, Roser
   Jimenez-Murcia, Susana
   Gonzalez-Monje, Inmaculada
   Esteve-Luque, Virginia
   Cuenca-Royo, Aida
   Gomez-Martinez, Carlos
   Paz-Graniel, Indira
   Forcano, Laura
   Fernandez-Aranda, Fernando
TI Metabolic, Affective and Neurocognitive Characterization of Metabolic
   Syndrome Patients with and without Food Addiction. Implications for
   Weight Progression
SO NUTRIENTS
LA English
DT Article
DE food addiction; metabolic syndrome; neurocognitive state; depression;
   quality of life
ID MONTREAL COGNITIVE ASSESSMENT; HEALTH SURVEY; FOLLOW-UP; SCALE 2.0;
   OBESITY; ASSOCIATIONS; SAMPLE; DEPRESSION; VALIDATION; POPULATION
AB According to the food addiction (FA) model, the consumption of certain types of food could be potentially addictive and can lead to changes in intake regulation. We aimed to describe metabolic parameters, dietary characteristics, and affective and neurocognitive vulnerabilities of individuals with and without FA, and to explore its influences on weight loss progression. The sample included 448 adults (55-75 years) with overweight/obesity and metabolic syndrome from the PREDIMED-Plus cognition sub-study. Cognitive and psychopathological assessments, as well as dietary, biochemical, and metabolic measurements, were assessed at baseline. Weight progression was evaluated after a 3-year follow up. The presence of FA was associated with higher depressive symptomatology, neurocognitive decline, low quality of life, high body mass index (BMI), and high waist circumference, but not with metabolic comorbidities. No differences were observed in the dietary characteristics except for the saturated and monounsaturated fatty acids consumption. After three years, the presence of FA at baseline resulted in a significantly higher weight regain. FA is associated with worse psychological and neurocognitive state and higher weight regain in adults with metabolic syndrome. This condition could be an indicator of bad prognosis in the search for a successful weight loss process.
C1 [Camacho-Barcia, Lucia; Munguia, Lucero; Lucas, Ignacio; Jimenez-Murcia, Susana; Fernandez-Aranda, Fernando] Univ Hosp Bellvitge IDIBELL, Dept Psychiat, Barcelona 08907, Spain.
   [de la Torre, Rafael; Salas-Salvado, Jordi; Pinto, Xavier; Corella, Dolores; Granero, Roser; Jimenez-Murcia, Susana; Gonzalez-Monje, Inmaculada; Cuenca-Royo, Aida; Gomez-Martinez, Carlos; Paz-Graniel, Indira; Forcano, Laura; Fernandez-Aranda, Fernando] Carlos III Hlth Inst, CIBER Physiol Obes & Nutr CIBEROBN, Madrid 28029, Spain.
   [de la Torre, Rafael; Cuenca-Royo, Aida; Forcano, Laura] Inst Hosp Mar Invest Mediques IMIM, Integrat Pharmacol & Neurosci Syst, Barcelona 08003, Spain.
   [de la Torre, Rafael] Univ Pompeu Fabra, Dept Expt & Hlth Sci CEXS UPF, Barcelona 08002, Spain.
   [Salas-Salvado, Jordi; Gomez-Martinez, Carlos; Paz-Graniel, Indira] Univ Rovira & Virgili, Dept Biochem & Biotechnol, Human Nutr Unit, Reus, Spain.
   [Salas-Salvado, Jordi; Gomez-Martinez, Carlos; Paz-Graniel, Indira] Inst Invest Pere Virgili IISPV, Reus, Spain.
   [Salas-Salvado, Jordi] Sant Joan Univ Hosp, Human Nutr Unit, Reus 43201, Spain.
   [Pinto, Xavier; Esteve-Luque, Virginia] Univ Hosp Bellvitge IDIBELL, Internal Med, Lipids & Vasc Risk Unit, Barcelona 08907, Spain.
   [Pinto, Xavier; Jimenez-Murcia, Susana; Fernandez-Aranda, Fernando] Univ Barcelona, Sch Med & Hlth Sci, Dept Clin Sci, Barcelona 08907, Spain.
   [Corella, Dolores; Gonzalez-Monje, Inmaculada] Univ Valencia, Dept Prevent Med, Valencia 46010, Spain.
   [Granero, Roser] Autonomous Univ Barcelona, Dept Psychobiol & Methodol, Barcelona 08193, Spain.
C3 Institut d'Investigacio Biomedica de Bellvitge (IDIBELL); Bellvitge
   University Hospital; University of Barcelona; CIBER - Centro de
   Investigacion Biomedica en Red; CIBEROBN; Hospital del Mar Research
   Institute; Pompeu Fabra University; Universitat Rovira i Virgili;
   Universitat Rovira i Virgili; Institut d'Investigacio Sanitaria Pere
   Virgili (IISPV); University of Barcelona; Institut d'Investigacio
   Biomedica de Bellvitge (IDIBELL); Bellvitge University Hospital;
   University of Barcelona; University of Valencia; Autonomous University
   of Barcelona
RP Fernández-Aranda, F (corresponding author), Univ Hosp Bellvitge IDIBELL, Dept Psychiat, Barcelona 08907, Spain.; Fernández-Aranda, F (corresponding author), Carlos III Hlth Inst, CIBER Physiol Obes & Nutr CIBEROBN, Madrid 28029, Spain.; Fernández-Aranda, F (corresponding author), Univ Barcelona, Sch Med & Hlth Sci, Dept Clin Sci, Barcelona 08907, Spain.
EM luciacamacho@hotmail.com; laarcreed_lm@hotmail.com;
   ignacio.lucas.adell@gmail.com; RTorre@imim.es; jordi.salas@urv.cat;
   xpinto@bellvitgehospital.cat; dolores.corella@uv.es;
   roser.granero@uab.cat; sjimenez@bellvitgehospital.cat;
   inmaagonzalez@gmail.com; vesteve@bellvitgehospital.cat; acuenca@imim.es;
   carlos.gomez@urv.cat; indiradelsocorro.paz@urv.cat; lforcano@imim.es;
   ffernandez@bellvitgehospital.cat
RI FORCANO, LAURA/AAP-1933-2020; de la Torre, Rafael/D-3561-2018;
   Paz-Graniel, Indira/ABH-2583-2020; Munguía, Lucero/AAA-6252-2021; Pintó,
   Xavier/AGI-4297-2022; JIMENEZ-MURCIA, SUSANA/L-9786-2014; Lucas Adell,
   Ignacio/P-9102-2016; Camacho-Barcia, Lucia/AAB-2096-2021; Granero,
   Roser/F-9492-2016; Salas-Salvado, Jordi/C-7229-2017; FERNANDEZ-ARANDA,
   FERNANDO/L-9762-2014; Forcano Gamazo, Laura/B-1154-2017; Gomez Martinez,
   Carlos/AGJ-6387-2022; Corella, Dolores/L-9888-2014
OI JIMENEZ-MURCIA, SUSANA/0000-0002-3596-8033; Lucas Adell,
   Ignacio/0000-0001-9426-5082; Camacho-Barcia, Lucia/0000-0002-5989-936X;
   de la Torre, Rafael/0000-0002-6765-1866; Granero,
   Roser/0000-0001-6308-3198; Salas-Salvado, Jordi/0000-0003-2700-7459; Paz
   Graniel, Indira/0000-0002-3204-6877; FERNANDEZ-ARANDA,
   FERNANDO/0000-0002-2968-9898; Cuenca Royo, Aida/0000-0001-8551-5457;
   Esteve-Luque, Virginia/0000-0002-7631-8301; Forcano Gamazo,
   Laura/0000-0002-8478-1451; Munguia, Lucero/0000-0002-9751-810X; Pinto
   Sala, Xavier/0000-0002-2216-2444; Gomez Martinez,
   Carlos/0000-0002-3077-6702; Corella, Dolores/0000-0002-2366-4104
FU Instituto de Salud Carlos III (ISCIII), through the Fondo de
   Investigacion para la Salud (FIS) - European Regional Development Fund
   [PI13/00673, PI13/00492, PI13/00272, PI13/01123, PI13/00462, PI13/00233,
   PI13/02184, PI13/00728, PI13/01090, PI13/01056, PI14/01722, PI14/00636,
   PI14/00618, PI14/00696, PI14/01206, PI14/01919, PI14/00853, PI14/01374,
   PI14/00972, PI14/00728]; Recercaixa [2013ACUP00194]; Consejeria de Salud
   de la Junta de Andalucia [PI0458/2013, PS0358/2016, PI0137/2018];
   Generalitat Valenciana [PROMETEO/2017/017]; SEMERGEN grant; Department
   of Health of the Generalitat de Catalunya by the call "Accio
   instrumental de programes de recerca orientats en l'ambit de la recerca
   i la innovacio en salut" [SLT006/17/00246]; Spanish Ministry of
   Education, Culture and Sports [FPU 17/01925]; University of Rovira i
   Virgili [2020PMF-PIPF-37]; ICREA under the ICREA Academia program; CIBER
   Fisiopatologia de la Obesidad y Nutricion (CIBEROBN); Department of
   Health of the Generalitat de Catalunya by the call "Pla estrategic de
   recerca i innovacio en salut (PERIS)" [SLT006/17/00246]; EU-H2020 Grant
   (Eat2beNICE/H2020-SFS-2016-2) [728018]; EU-H2020 Grant
   (PRIME/H2020-SC1-BHC-2018-2020) [847879]; The Instituto de Salud Carlos
   III (ISCIII), through the Fondo de Investigacion para la Salud (FIS) -
   European Regional Development Fund [PI17/01827, PI17/00532, PI17/00215,
   PI17/01441, PI17/00508, PI17/01732, PI17/00926, PI19/00957, PI19/00386,
   PI19/00309, PI19/01032, PI19/00576, PI19/00017, PI19/01226, PI19/00781];
   'Instituto de Salud Carlos III (ISCIII), through the Fondo de
   Investigacion para la Salud (FIS) - European Regional Development Fund'
   [PI19/01560, PI19/01332, PI20/01802, PI20/00138, PI20/01532, PI20/00456,
   PI20/00339, PI20/00557, PI20/00886, PI20/01158, PI14/01471, PI16/00473,
   PI16/00662]; "Instituto de Salud Carlos III (ISCIII), through the Fondo
   de Investigacion para la Salud (FIS) - European Regional Development
   Fund" [PI16/01873, PI16/01094, PI16/00501, PI16/00533, PI16/00381,
   PI16/00366, PI16/01522, PI16/01120, PI17/00764, PI17/01183, PI17/00855,
   PI17/01347, PI17/00525]
FX This work was supported by the official Spanish Institutions for funding
   scientific biomedical research, CIBER Fisiopatologia de la Obesidad y
   Nutricion (CIBEROBN) and Instituto de Salud Carlos III (ISCIII), through
   the Fondo de Investigacion para la Salud (FIS), which is co-funded by
   the European Regional Development Fund (six coordinated FIS projects
   leaded by JS-S and JVi, including the following projects: PI13/00673,
   PI13/00492, PI13/00272, PI13/01123, PI13/00462, PI13/00233, PI13/02184,
   PI13/00728, PI13/01090, PI13/01056, PI14/01722, PI14/00636, PI14/00618,
   PI14/00696, PI14/01206, PI14/01919, PI14/00853, PI14/01374, PI14/00972,
   PI14/00728, PI14/01471, PI16/00473, PI16/00662, PI16/01873, PI16/01094,
   PI16/00501, PI16/00533, PI16/00381, PI16/00366, PI16/01522, PI16/01120,
   PI17/00764, PI17/01183, PI17/00855, PI17/01347, PI17/00525, PI17/01827,
   PI17/00532, PI17/00215, PI17/01441, PI17/00508, PI17/01732, PI17/00926,
   PI19/00957, PI19/00386, PI19/00309, PI19/01032, PI19/00576, PI19/00017,
   PI19/01226, PI19/00781, PI19/01560, PI19/01332, PI20/01802, PI20/00138,
   PI20/01532, PI20/00456, PI20/00339, PI20/00557, PI20/00886, PI20/01158);
   the Especial Action Project entitled: Implementacion y evaluacion de una
   intervencion intensiva sobre la actividad fisica Cohorte PREDIMED-Plus
   grant to JS-S; the Recercaixa (number 2013ACUP00194) grant to JS-S;
   grants from the Consejeria de Salud de la Junta de Andalucia
   (PI0458/2013, PS0358/2016, PI0137/2018); the PROMETEO/2017/017 grant
   from the Generalitat Valenciana; the SEMERGEN grant; None of the funding
   sources took part in the design, collection, analysis, interpretation of
   the data, or writing the report, or in the decision to submit the
   manuscript for publication. None of the funding sources took part in the
   design, collection, analysis, or interpretation of the data or in the
   decision to submit the manuscript for publication. We thank CERCA
   Programme/Generalitat de Catalunya for institutional support and partial
   support was also provided by SLT006/17/00246, funded by the Department
   of Health of the Generalitat de Catalunya by the calls "Accio
   instrumental de programes de recerca orientats en l'ambit de la recerca
   i la innovacio en salut" and "Pla estrategic de recerca i innovacio en
   salut (PERIS)". This research was also partially funded by EU-H2020
   Grants (Eat2beNICE/H2020-SFS-2016-2; Ref 728018; and
   PRIME/H2020-SC1-BHC-2018-2020; Ref: 847879). IP-G receives a grant from
   the Spanish Ministry of Education, Culture and Sports (FPU 17/01925).
   C.G.-M. receives a predoctoral grant from the University of Rovira i
   Virgili (2020PMF-PIPF-37); J.S-S. is partially supported by ICREA under
   the ICREA Academia program.
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NR 75
TC 7
Z9 7
U1 0
U2 5
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD AUG
PY 2021
VL 13
IS 8
AR 2779
DI 10.3390/nu13082779
PG 13
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nutrition & Dietetics
GA UH7HJ
UT WOS:000690096700001
PM 34444940
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Scheewe, TW
   Jörg, F
   Takken, T
   Deenik, J
   Vancampfort, D
   Backx, FJG
   Cahn, W
AF Scheewe, Thomas W.
   Jorg, Frederike
   Takken, Tim
   Deenik, Jeroen
   Vancampfort, Davy
   Backx, Frank J. G.
   Cahn, Wiepke
TI Low Physical Activity and Cardiorespiratory Fitness in People With
   Schizophrenia: A Comparison With Matched Healthy Controls and
   Associations With Mental and Physical Health
SO FRONTIERS IN PSYCHIATRY
LA English
DT Article
DE physical activity; sedentary behavior; Cardiorespiratory fitness;
   schizophrenia; matched healthy controls
ID SEDENTARY BEHAVIOR; ENERGY-EXPENDITURE; CARDIOVASCULAR-DISEASE;
   CARDIOMETABOLIC RISK; MULTISENSOR ARMBAND; SELF-REPORT; SCALE;
   MORTALITY; METAANALYSIS; DEPRESSION
AB Introduction: The aim of this study was to objectively assess time spent in physical activity (PA) and sedentary behavior (SB) in patients with schizophrenia compared to healthy controls matched for age, gender and socioeconomic status. Associations between both PA and cardiorespiratory fitness (CRF) and mental and physical health parameters in patients with schizophrenia were examined.
   Materials and Methods: Moderate and vigorous PA (MVPA), moderate PA, vigorous PA, total and active energy expenditure (TEE and AEE), number of steps, lying down and sleeping time was assessed with SenseWear Pro-2 body monitoring system for three 24-h bouts in patients with schizophrenia (n = 63) and matched healthy controls (n = 55). Severity of symptoms (Positive and Negative Syndrome Scale and Montgomery and Asberg Depression Rating Scale), CRF (peak oxygen uptake, VO2peak) , body mass index (BMI), and metabolic syndrome were assessed.
   Results: Patients with schizophrenia performed less MVPA and moderate activity had lower TEE and AEE, spent more time per day lying down and sleeping, and had poorer CRF compared to healthy controls. The amount of MVPA, but especially CRF was associated with severity of negative symptoms in patients with schizophrenia. Only CRF was associated with BMI.
   Discussion: The current data offer further evidence for interventions aiming to increase physical activity and decrease sedentary behavior. Given strong associations of CRF with both negative symptoms and BMI, treatment aimed at CRF-improvement may prove to be effective.
C1 [Scheewe, Thomas W.; Cahn, Wiepke] Univ Med Ctr Utrecht, Rudolf Magnus Inst Neurosci, Dept Psychiat, Utrecht, Netherlands.
   [Scheewe, Thomas W.] Windesheim Univ Appl Sci, Dept Human Movement & Educ, Zwolle, Netherlands.
   [Jorg, Frederike] Univ Groningen, Univ Med Ctr Groningen, Univ Ctr Psychiat, Rob Giel Res Ctr, Groningen, Netherlands.
   [Jorg, Frederike] GGZ Friesland Friesland Mental Hlth Serv, Res Dept, Leeuwarden, Netherlands.
   [Takken, Tim] Univ Med Ctr Utrecht, Wilhelmina Childrens Hosp, Child Dev & Exercise Ctr, Utrecht, Netherlands.
   [Deenik, Jeroen] GGz Cent, Amersfoort, Netherlands.
   [Vancampfort, Davy] Katholieke Univ Leuven, Univ Psychiat Ctr, Leuven, Belgium.
   [Vancampfort, Davy] Katholieke Univ Leuven, Dept Rehabil Sci, Leuven, Belgium.
   [Backx, Frank J. G.] Univ Med Ctr Utrecht, Rudolf Magnus Inst Neurosci, Dept Rehabil Phys Therapy Sci & Sports, Utrecht, Netherlands.
C3 Utrecht University; Utrecht University Medical Center; University of
   Groningen; Wilhelmina Kinderziekenhuis; Utrecht University; Utrecht
   University Medical Center; KU Leuven; KU Leuven; Utrecht University;
   Utrecht University Medical Center
RP Scheewe, TW (corresponding author), Univ Med Ctr Utrecht, Rudolf Magnus Inst Neurosci, Dept Psychiat, Utrecht, Netherlands.; Scheewe, TW (corresponding author), Windesheim Univ Appl Sci, Dept Human Movement & Educ, Zwolle, Netherlands.
EM tw.scheewe@windesheim.nl
RI Jörg, Frederike/B-1325-2014; Vancampfort, Davy/AAD-1987-2019; Deenik,
   J./ABE-4954-2021; Takken, Tim/A-9912-2010
OI Deenik, Jeroen/0000-0002-1463-8676
FU UMCU, Netherlands; Lilly Pharmaceuticals, Houten, the Netherlands
   [Ho01-TOPFIT]; Janssen Pharmaceuticals, Tilburg, Netherlands; Dutch
   Psychomotor Therapy Foundation, Utrecht, the Netherlands; Dutch Diabetes
   Research Foundation [2007.00.040]
FX This project was funded primarily by the UMCU, Netherlands. In addition,
   this work was funded by the Dutch Diabetes Research Foundation (Project
   Grant 2007.00.040). A research assistant was partly funded by Lilly
   Pharmaceuticals, Houten, the Netherlands (Project Grant Ho01-TOPFIT).
   Janssen Pharmaceuticals, Tilburg, Netherlands made a general financial
   contribution for this project. The Dutch Psychomotor Therapy Foundation,
   Utrecht, the Netherlands gave a financial contribution for this project.
   The study sponsors had no further role in study design, in the
   collection, analysis and interpretation of data; in the writing of the
   report; and in the decision to submit the paper for publication.
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NR 46
TC 43
Z9 43
U1 0
U2 11
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-0640
J9 FRONT PSYCHIATRY
JI Front. Psychiatry
PD FEB 28
PY 2019
VL 10
AR 87
DI 10.3389/fpsyt.2019.00087
PG 8
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA HN0GG
UT WOS:000459863900001
PM 30873051
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Warli, SM
   Alamsyah, MT
   Nasution, AT
   Kadar, DD
   Siregar, GP
   Prapiska, FF
AF Warli, Syah Mirsya
   Alamsyah, Mohammad Taufiq
   Nasution, Alwi Thamrin
   Kadar, Dhirajaya Dharma
   Siregar, Ginanda Putra
   Prapiska, Fauriski Febrian
TI The Assessment of Male Erectile Dysfunction Characteristics in Patients
   Undergoing Continuous Ambulatory Peritoneal Dialysis and Hemodialysis
   Using the International Index of Erectile Function (IIEF-5) Combined
   with Hospital Anxiety and Depression Scales
SO INTERNATIONAL JOURNAL OF NEPHROLOGY AND RENOVASCULAR DISEASE
LA English
DT Article
DE erectile dysfunction; CAPD; HD; IIEF-5
ID QUALITY-OF-LIFE; SEXUAL DYSFUNCTION; METABOLIC SYNDROME; RISK-FACTORS;
   MEN
AB Purpose: To determine the differences in mean scores of erectile dysfunctions (EDs) assessed by the International Index of Erectile Function (IIEF-5) questionnaire between patients with chronic kidney disease (CKD) undergoing hemodialysis and patients underPatients and Methods: This is an analytic observational study with a cross-sectional design that was conducted from June to December 2022 at the Urology Center of Haji Adam Malik General Hospital and Rasyida Kidney Specialized Hospital. The sample of this study were male CKD-patients who underwent regular hemodialysis (HD) and who underwent CAPD, and met the inclusion and exclusion criteria. Psychological disorders experienced during therapy session are considered as risk factors and assessed via the Hospital Anxiety and Depression Scale (HADS). These disorders assessment was used to evaluate the severity of the patients' anxiety and depressive symptoms. Statistical data analysis was carried out. Results: Both groups had HADS-A and HADS-D scores with an average <7, classified as normal anxiety and depression. Most of the patients in the HD group had mild-to-moderate ED (28.6%), while in the CAPD group had mild severity of ED (38.1%). There were no significant differences in severity of ED between patients undergoing HD and CAPD (p > 0.05). However, there was a significant difference in ED scores (IIEF-5) between patients undergoing HD and those with CAPD (p < 0.05), in which patients in the CAPD group had a higher IIEF-5 score. In addition, there was a significant positive correlation with moderate strength (p<0.001; r=0.494) between anxiety disorders and ED disorders in patients undergoing HD and CAPD, whereas there is no significant correlation between depressive disorders and ED conditions (p > 0.05).Conclusion: There was a significant difference in IIEF-5 scores between patients undergoing HD and CAPD.
C1 [Warli, Syah Mirsya; Kadar, Dhirajaya Dharma; Siregar, Ginanda Putra; Prapiska, Fauriski Febrian] Univ Sumatera Utara, Haji Adam Malik Gen Hosp, Fac Med, Div Urol,Dept Surg, Medan, Indonesia.
   [Warli, Syah Mirsya] Univ Sumatera Utara, Univ Sumatera Utara Hosp, Dept Urol, Medan, Indonesia.
   [Alamsyah, Mohammad Taufiq] Univ Indonesia, Haji Adam Malik Gen Hosp, Fac Med, Dept Urol, Medan, Indonesia.
   [Nasution, Alwi Thamrin] Univ Sumatera Utara, Haji Adam Malik Gen Hosp, Div Nephrol, Dept Internal Med,Fac Med, Medan, Indonesia.
C3 University of North Sumatra; University of North Sumatra; University of
   Indonesia; University of North Sumatra
RP Warli, SM (corresponding author), Univ Sumatera Utara, Haji Adam Malik Gen Hosp, Fac Med, Div Urol,Dept Surg, Medan, Indonesia.
EM warli@usu.ac.id
RI Warli, Syah Mirsya/GLS-4506-2022; Prapiska, Fauriski/AAV-5018-2021
CR Antonucci M, 2015, ARCH ITAL UROL ANDRO, V87, P299, DOI 10.4081/aiua.2015.4.299
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NR 22
TC 0
Z9 0
U1 0
U2 4
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-7058
J9 INT J NEPHROL RENOV
JI Int. J. Nephrol. Renov. Dis.
PY 2023
VL 16
BP 155
EP 161
DI 10.2147/IJNRD.S402540
PG 7
WC Urology & Nephrology
WE Emerging Sources Citation Index (ESCI)
SC Urology & Nephrology
GA G1GU7
UT WOS:000986734000001
PM 37180487
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Martini, D
   Marino, M
   Venturi, S
   Tucci, M
   Klimis-Zacas, D
   Riso, P
   Porrini, M
   Del Bo', C
AF Martini, Daniela
   Marino, Mirko
   Venturi, Samuele
   Tucci, Massimiliano
   Klimis-Zacas, Dorothy
   Riso, Patrizia
   Porrini, Marisa
   Del Bo', Cristian
TI Blueberries and their bioactives in the modulation of oxidative stress,
   inflammation and cardio/vascular function markers: a systematic review
   of human intervention studies
SO JOURNAL OF NUTRITIONAL BIOCHEMISTRY
LA English
DT Review
DE Blueberries; dietary intervention studies; Oxidative stress;
   Inflammation; Vascular; function; cardiovascular markers
ID PERIPHERAL ARTERIAL DYSFUNCTION; DOUBLE-BLIND; METABOLIC SYNDROME; STAGE
   1-HYPERTENSION; POSTMENOPAUSAL WOMEN; ANTIOXIDANT DEFENSE; INSULIN
   SENSITIVITY; VASCULAR FUNCTION; BLOOD-PRESSURE; FAT BREAKFAST
AB Blueberries represent a rich source of (poly)phenols and other bioactive compounds. Numerous in vitro and animal model studies documented the potential health-promoting properties of blueberries and blueberry-bioactives, while little is still known about their effects in humans. The objective of the present systematic review is to provide main evidence and the potential mechanisms of action of blueberry and its (poly)phenols in the regulation of markers related to oxidative stress, inflammation, vascular and cardiometabolic function in health and disease states. A total of 45 human intervention studies were included in this review. Overall, the evidence suggests that blueberries may play a role in the improvement of markers of vascular function. Their effects were observed following both post-prandial and long-term consumption, particularly in subjects with risk factors and/or disease conditions. Conversely, the conflicting results on inflammation, oxidative stress and cardiometabolic risk markers were most likely due to differences among studies in terms of study design, subject characteristics, duration of intervention, dosage, and type of biomarkers analyzed. For these reasons, high-quality, well -designed, human intervention studies are warranted to strengthen the current findings on vascular function and provide more evidence about the impact of blueberries on the different markers considered. In addition, studies focusing on the relationship between the structure and the function of (poly)phenols will be fundamental for a better comprehension of the mechanisms behind the health effects observed. (c) 2022 Elsevier Inc. All rights reserved.
C1 [Martini, Daniela; Marino, Mirko; Venturi, Samuele; Tucci, Massimiliano; Riso, Patrizia; Porrini, Marisa; Del Bo', Cristian] Univ Milan, Dept Food Environm & Nutr Sci, Div Human Nutr, Via G Celoria 2, I-20133 Milan, Italy.
   [Klimis-Zacas, Dorothy] Univ Maine, Sch Food & Agr, Orono, ME USA.
C3 University of Milan; University of Maine System; University of Maine
   Orono
RP Riso, P (corresponding author), Univ Milan, Dept Food Environm & Nutr Sci, Div Human Nutr, Via G Celoria 2, I-20133 Milan, Italy.
EM patrizia.riso@unimi.it
RI porrini, marisa/AAF-6788-2021; Del Bò, Cristian/AFT-1534-2022; Martini,
   Daniela/S-2499-2019; Riso, Patrizia/AAC-2072-2019; Marino,
   Mirko/AAI-5389-2020; martini, daniela/D-6241-2015
OI MARINO, MIRKO/0000-0001-9913-4380; martini, daniela/0000-0001-8298-926X
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NR 114
TC 32
Z9 33
U1 10
U2 46
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0955-2863
EI 1873-4847
J9 J NUTR BIOCHEM
JI J. Nutr. Biochem.
PD JAN
PY 2023
VL 111
AR 109154
DI 10.1016/j.jnutbio.2022.109154
EA OCT 2022
PG 24
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA 6X9IM
UT WOS:000896720000001
PM 36150681
DA 2025-06-11
ER

PT J
AU Leysen, H
   Walter, D
   Clauwaert, L
   Hellemans, L
   van Gastel, J
   Vasudevan, L
   Martin, B
   Maudsley, S
AF Leysen, Hanne
   Walter, Deborah
   Clauwaert, Lore
   Hellemans, Lieselot
   van Gastel, Jaana
   Vasudevan, Lakshmi
   Martin, Bronwen
   Maudsley, Stuart
TI The Relaxin-3 Receptor, RXFP3, Is a Modulator of Aging-Related Disease
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE relaxin-family peptide receptor 3; aging; G-protein-coupled receptors;
   DNA; damage; GIT2
ID PROTEIN-COUPLED RECEPTORS; GTPASE-ACTIVATING PROTEINS; OXIDATIVE STRESS;
   FAMILY PEPTIDE; ALZHEIMERS-DISEASE; BODY-WEIGHT; CALORIC RESTRICTION;
   METABOLIC SYNDROME; FOOD-INTAKE; GIT FAMILY
AB During the aging process our body becomes less well equipped to deal with cellular stress, resulting in an increase in unrepaired damage. This causes varying degrees of impaired functionality and an increased risk of mortality. One of the most effective anti-aging strategies involves interventions that combine simultaneous glucometabolic support with augmented DNA damage protection/repair. Thus, it seems prudent to develop therapeutic strategies that target this combinatorial approach. Studies have shown that the ADP-ribosylation factor (ARF) GTPase activating protein GIT2 (GIT2) acts as a keystone protein in the aging process. GIT2 can control both DNA repair and glucose metabolism. Through in vivo co-regulation analyses it was found that GIT2 forms a close coexpression-based relationship with the relaxin-3 receptor (RXFP3). Cellular RXFP3 expression is directly affected by DNA damage and oxidative stress. Overexpression or stimulation of this receptor, by its endogenous ligand relaxin 3 (RLN3), can regulate the DNA damage response and repair processes. Interestingly, RLN3 is an insulin-like peptide and has been shown to control multiple disease processes linked to aging mechanisms, e.g., anxiety, depression, memory dysfunction, appetite, and anti-apoptotic mechanisms. Here we discuss the molecular mechanisms underlying the various roles of RXFP3/RLN3 signaling in aging and age-related disorders.
C1 [Leysen, Hanne; Walter, Deborah; Clauwaert, Lore; Hellemans, Lieselot; van Gastel, Jaana; Maudsley, Stuart] Univ Antwerp, Receptor Biol Lab, B-2610 Antwerp, Belgium.
   [van Gastel, Jaana] SGS Belgium, Interc Business Pk,Gen Wittelaan 19-A5, B-2800 Mechelen, Belgium.
   [Martin, Bronwen] Univ Antwerp, Fac Pharmaceut Biomed & Vet Sci, B-2610 Antwerp, Belgium.
C3 University of Antwerp; University of Antwerp
RP Maudsley, S (corresponding author), Univ Antwerp, Receptor Biol Lab, B-2610 Antwerp, Belgium.
EM hanne.leysen@uantwerpen.be; deborah.water@uantwerpen.be;
   lore.clauwaert@student.uantwerpen.be;
   lieselot.hellemans@student.uantwerpen.be; jaana.vangastel@uantwerpen.be;
   laxvasudevan@gmail.com; bronwen.martin@uantwerpen.be;
   stuart.maudsley@uantwerpen.be
RI Maudsley, Stuart/AAV-9929-2021; Maudsley, Stuart/O-7565-2015; Leysen,
   Hanne/AAA-1954-2020
OI Vasudevan, Lakshmi/0000-0001-8825-298X; Maudsley,
   Stuart/0000-0002-1868-184X; Leysen, Hanne/0000-0002-5852-9033; Walter,
   Deborah/0000-0002-0350-6280
FU FWO-OP/Odysseus Program [42/FA010100/32/6484]; FWO PhD Fundamental
   Research grant [1198020N]; University of Antwerp Seal of Excellence
   Award
FX This research was funded by the FWO-OP/Odysseus Program
   (42/FA010100/32/6484), FWO PhD Fundamental Research grant (1198020N) and
   the University of Antwerp Seal of Excellence Award.
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NR 212
TC 13
Z9 13
U1 2
U2 11
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD APR
PY 2022
VL 23
IS 8
AR 4387
DI 10.3390/ijms23084387
PG 22
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Biochemistry & Molecular Biology; Chemistry
GA 0S1LO
UT WOS:000786043300001
PM 35457203
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Dixon, JB
   Dixon, ME
   Anderson, ML
   Schachter, L
   O'Brien, PE
AF Dixon, John B.
   Dixon, Maureen E.
   Anderson, Margaret L.
   Schachter, Linda
   O'Brien, Paul E.
TI Daytime sleepiness in the obese: Not as simple as obstructive sleep
   apnea
SO OBESITY
LA English
DT Article
DE sleep disorders; metabolic syndrome; depression; quality of life
ID C-REACTIVE PROTEIN; INSULIN-RESISTANCE; METABOLIC SYNDROME; VISCERAL
   OBESITY; SEVERELY OBESE; SENSITIVITY; FATIGUE; INERTIA; SCALE
AB Objective: Excessive daytime sleepiness is a common symptom in obese patients, but what drives this condition is unclear. The objective was to look for clinical, anthropometric, biochemical, and polysomnographic predictors of excessive daytime sleepiness as measured by the Epworth Sleepiness Scale (ESS) in obese patients.
   Research Methods and Procedures: The ESS questionnaire was completed by 1055 consecutive patients presenting for obesity surgery. Those at high risk for obstructive sleep apnea (n = 33 1) had diagnostic overnight polysomnography preoperatively. All patients had preoperative clinical, hematologic, and biochemical measurements and completed multiple questionnaires.
   Results: There was no significant relationship between ESS score and any measure of diagnostic polysomnography factors, including total apnea hypopnea index. Subtle increases in ESS scores were reported in men, older patients, and those with type 2 diabetes. However, general demographic, anthropometric, and biochemical measures of the metabolic syndrome explained only 3% of ESS score variance, and inflammatory markers of C-reactive protein and total white cell count were not predictive. Poor Short Form-36 energy scores (b = -0.18, p < 0.001) and high Beck Depression Inventory scores were predictive of higher ESS scores (b = 0.15, p < 0.001) and, along with increasing age and male gender, explained 10% of variance. Symptoms related to disturbed nocturnal sleep explained 30% of variance.
   Conclusion: In severely obese subjects, increased daytime sleepiness does not seem to be driven by obstructive sleep apnea, the degree of obesity, or anthropometric, metabolic, or inflammatory markers of the metabolic syndrome. It is, however, associated with poor energy, symptoms of depression, and symptoms of nocturnal sleep disturbance.
C1 Alfred Hosp, Ctr Obes Res & Educ, Melbourne, Vic 3181, Australia.
C3 Florey Institute of Neuroscience & Mental Health; Howard Florey
   Institute Affiliates
RP Dixon, JB (corresponding author), Alfred Hosp, Ctr Obes Res & Educ, Melbourne, Vic 3181, Australia.
EM john.dixon@med.monash.edu.au
RI Dixon, John/A-5318-2011
OI Dixon, John/0000-0001-6399-7010
CR Babu AR, 2005, ARCH INTERN MED, V165, P447, DOI 10.1001/archinte.165.4.447
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NR 38
TC 94
Z9 97
U1 0
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1930-7381
EI 1930-739X
J9 OBESITY
JI Obesity
PD OCT
PY 2007
VL 15
IS 10
BP 2504
EP 2511
DI 10.1038/oby.2007.297
PG 8
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 223NK
UT WOS:000250377300017
PM 17925477
OA Bronze
DA 2025-06-11
ER

PT J
AU Purzycka-Bohdan, D
   Kisielnicka, A
   Bohdan, M
   Szczerkowska-Dobosz, A
   Sobalska-Kwapis, M
   Nedoszytko, B
   Nowicki, RJ
AF Purzycka-Bohdan, Dorota
   Kisielnicka, Anna
   Bohdan, Michal
   Szczerkowska-Dobosz, Aneta
   Sobalska-Kwapis, Marta
   Nedoszytko, Boguslaw
   Nowicki, Roman J.
TI Analysis of the Potential Genetic Links between Psoriasis and
   Cardiovascular Risk Factors
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE psoriasis; comorbidities; cardiovascular risk; genetic background
ID METABOLIC SYNDROME; ADIPOSE-TISSUE; LEPTIN GENE; INSULIN SENSITIVITY;
   LIPID-LEVELS; ASSOCIATION; POLYMORPHISM; DISEASE; OBESITY; DEPRESSION
AB Cardiovascular risk factors are one of the most common comorbidities in psoriasis. A higher prevalence of hypertension, insulin resistance and type 2 diabetes, dyslipidemia, obesity, metabolic syndrome, depression, as well as cardiovascular disease was confirmed in psoriatic patients in comparison to the general population. Data suggest that psoriasis and systemic inflammatory disorders may originate from the pleiotropic interactions with many genetic pathways. In this review, the authors present the current state of knowledge on the potential genetic links between psoriasis and cardiovascular risk factors. The understanding of the processes linking psoriasis with cardiovascular risk factors can lead to improvement of psoriasis management in the future.
C1 [Purzycka-Bohdan, Dorota; Kisielnicka, Anna; Szczerkowska-Dobosz, Aneta; Nedoszytko, Boguslaw; Nowicki, Roman J.] Med Univ Gdansk, Dept Dermatol Venereol & Allergol, PL-80214 Gdansk, Poland.
   [Bohdan, Michal] Med Univ Gdansk, Dept Cardiol 1, PL-80211 Gdansk, Poland.
   [Sobalska-Kwapis, Marta] Univ Lodz, Fac Biol & Environm Protect, Dept Mol Biophys, Biobank Lab, PL-90231 Lodz, Poland.
   [Nedoszytko, Boguslaw] Invicta Fertil & Reprod Ctr, Mol Lab, PL-81740 Sopot, Poland.
C3 Fahrenheit Universities; Medical University Gdansk; Fahrenheit
   Universities; Medical University Gdansk; University of Lodz
RP Purzycka-Bohdan, D (corresponding author), Med Univ Gdansk, Dept Dermatol Venereol & Allergol, PL-80214 Gdansk, Poland.
EM purzycka-bohdan@gumed.edu.pl; a.kisielnicka@gumed.edu.pl;
   michal.bohdan@gumed.edu.pl; adobosz@gumed.edu.pl;
   marta.sobalska@biol.uni.lodz.pl; bned@gumed.edu.pl;
   rnowicki@gumed.edu.pl
RI Szczerkowska-Dobosz, Aneta/AAA-1535-2020; Bohdan, Michał/AFH-9583-2022;
   Nedoszytko, Boguslaw/AAY-5079-2020; Nowicki, Roman/U-3148-2018;
   Czarnecka, Anna/ABB-9807-2020
OI Purzycka-Bohdan, Dorota/0000-0002-6089-8030; Bohdan,
   Michal/0000-0002-3496-2238; Nedoszytko, Boguslaw/0000-0002-6286-0693;
   Czarnecka, Anna/0000-0001-8519-4892; Sobalska-Kwapis,
   Marta/0000-0003-1982-2621; Nowicki, Roman/0000-0003-4768-1387
FU Polish Ministry of Science and Higher Education [02-0066/07/253]
FX The research was supported by funds from the Polish Ministry of Science
   and Higher Education (02-0066/07/253). We declare no other external
   funding.
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NR 105
TC 17
Z9 17
U1 3
U2 11
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD AUG
PY 2021
VL 22
IS 16
AR 9063
DI 10.3390/ijms22169063
PG 17
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA UG6BR
UT WOS:000689335800001
PM 34445769
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Diniz, BS
   Teixeira, AL
   Campos, AC
   Miranda, AS
   Rocha, NP
   Talib, LL
   Gattaz, WF
   Forlenza, OV
AF Diniz, Breno S.
   Teixeira, Antonio L.
   Campos, Alline C.
   Miranda, Aline S.
   Rocha, Natalia P.
   Talib, Leda L.
   Gattaz, Wagner F.
   Forlenza, Orestes V.
TI Reduced serum levels of adiponectin in elderly patients with major
   depression
SO JOURNAL OF PSYCHIATRIC RESEARCH
LA English
DT Article
DE Late-life depression; Adiponectin; Biomarker; Elderly; Cognition;
   Physiopathology
ID MILD COGNITIVE IMPAIRMENT; ALZHEIMERS-DISEASE; MYOCARDIAL-INFARCTION;
   METABOLIC SYNDROME; MENTAL-DISORDER; ABSOLUTE AMOUNT; ADIPOSE-TISSUE;
   OLDER-ADULTS; PLASMA; ASSOCIATION
AB Recent studies have implicated adiponectin and other adipocytokines in brain function, particularly in processes related to memory and cognition. Blood levels of adiponectin are reduced in patients with primary cognitive disorders, such as Alzheimer's disease and mild cognitive impairment, and in adult patients with major depression. The aim of the present study is to determine serum levels of adiponectin in a sample of elderly patients with major depressive disorder (MOD) as compared to healthy older adults, and to examine the correlations between adiponectin levels and parameters indicative of mood and cognitive state. We recruited fifty-one unmedicated outpatients with late-life depression (LLD) and 47 age-matched controls in this study. The diagnosis of MDD was made according to the DSM-IV criteria, and the severity of depressive episode was determined with the 21-item Hamilton Depression Scale (HORS). Cognitive state was ascertained with the Cambridge Cognitive Test (CAMCOG) and the Mini-Mental State Examination (MMSE). Serum concentrations of adiponectin were determined using a sandwich ELISA method. Serum levels of adiponectin were significantly reduced in individuals with LLD (F = p < 0.001). Adiponectin level remained significantly reduced in after controlling for BMI index, scores on the CAMCOG, MMSE and HDRS and educational level (p < 0.001). Adiponectin levels showed a negative correlation with HORS scores (r = -0.59, p < 0.001) and BMI index (r = -0.42, p < 0.001); and showed a positive correlation with CAMCOG (r = 0.34, p < 0.01) and MMSE scores (r = 0.20, p = 0.05). The availability of circulating adiponectin is reduced in older adults with major depression, with likely implications on cognitive and mood state. Additional studies are required to determine whether this abnormality pertains to the pathophysiology of geriatric depression per se, or is a consequence of the morbid state. (C) 2012 Elsevier Ltd. All rights reserved.
C1 [Diniz, Breno S.] Univ Pittsburgh, Western Psychiat Inst & Clin, Dept Psychiat, Sch Med, Pittsburgh, PA 15213 USA.
   [Diniz, Breno S.; Talib, Leda L.; Gattaz, Wagner F.; Forlenza, Orestes V.] Univ Sao Paulo, Fac Med, Dept Psychiat, Lab Neurosci LIM 27, Sao Paulo, Brazil.
   [Diniz, Breno S.; Talib, Leda L.; Gattaz, Wagner F.; Forlenza, Orestes V.] Univ Sao Paulo, Fac Med, Inst Psychiat, Lab Neurosci LIM 27, Sao Paulo, Brazil.
   [Teixeira, Antonio L.; Campos, Alline C.; Miranda, Aline S.; Rocha, Natalia P.] Univ Fed Minas Gerais, Sch Med, Belo Horizonte, MG, Brazil.
   [Teixeira, Antonio L.; Campos, Alline C.; Miranda, Aline S.; Rocha, Natalia P.] Univ Fed Minas Gerais, Inst Biol Sci, Lab Immunopharmacol, Grp Neuroimmunol, Belo Horizonte, MG, Brazil.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE); University
   of Pittsburgh; Western Psychiatric Institute & Clinic of UPMC;
   Universidade de Sao Paulo; Universidade de Sao Paulo; Universidade
   Federal de Minas Gerais; Universidade Federal de Minas Gerais
RP Diniz, BS (corresponding author), Univ Pittsburgh, Western Psychiat Inst & Clin, Dept Psychiat, Sch Med, 3811 OHara St,Suite 466, Pittsburgh, PA 15213 USA.
EM brenosatler@gmail.com
RI Talib, Leda/AAJ-4669-2021; Miranda, Aline/AFM-2106-2022; Teixeira,
   Antonio/N-3315-2014; Gattaz, Wagner/C-4456-2012; Forlenza,
   Orestes/B-8848-2013; Diniz, Breno/H-8381-2019; Campos,
   Alline/A-8343-2013; Silva de Miranda, Aline/L-5507-2016; Rocha, Natalia
   Pessoa/S-4021-2018
OI Campos, Alline Cristina/0000-0003-4258-3198; Silva de Miranda,
   Aline/0000-0003-2811-7924; Rocha, Natalia Pessoa/0000-0003-2616-8082;
   Diniz, Breno/0000-0003-0653-1905; Teixeira, Antonio
   Lucio/0000-0002-9621-5422
FU FAPESP [09/52825-8, 02/12633-7]; Associacao Beneficente Alzira Denise
   Hertzog da Silva (ABADHS); CNPq; FAPEMIG; CAPES, Brazil
FX This work was supported by grants from FAPESP (09/52825-8 and
   02/12633-7), Associacao Beneficente Alzira Denise Hertzog da Silva
   (ABADHS), CNPq, FAPEMIG and CAPES, Brazil.
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NR 51
TC 74
Z9 78
U1 0
U2 22
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-3956
J9 J PSYCHIATR RES
JI J. Psychiatr. Res.
PD AUG
PY 2012
VL 46
IS 8
BP 1081
EP 1085
DI 10.1016/j.jpsychires.2012.04.028
PG 5
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 980AF
UT WOS:000306865300016
PM 22633396
DA 2025-06-11
ER

PT J
AU Iwasaki, M
   Sato, M
   Minagawa, K
   Manz, MC
   Yoshihara, A
   Miyazaki, H
AF Iwasaki, Masanori
   Sato, Misuzu
   Minagawa, Kumiko
   Manz, Michael C.
   Yoshihara, Akihiro
   Miyazaki, Hideo
TI Longitudinal Relationship Between Metabolic Syndrome and Periodontal
   Disease Among Japanese Adults Aged ≥70 Years: The Niigata Study
SO JOURNAL OF PERIODONTOLOGY
LA English
DT Article
DE Aged; epidemiology; longitudinal studies; metabolic syndrome X; oral
   medicine; periodontal diseases
ID OXIDATIVE STRESS; DIABETES-MELLITUS; REACTIVE OXYGEN; ASSOCIATION;
   MITOCHONDRIA; INFLAMMATION; ADIPONECTIN; POPULATION; GLUCOSE; OBESITY
AB Background: There has been little evaluation in longitudinal epidemiologic studies of the effect of metabolic syndrome (MetS) on periodontal status. The specific aim of this longitudinal study is to investigate whether MetS in the Japanese population could be a risk factor for periodontal disease.
   Methods: A total of 125 older adults from Japan for whom data were available for the years 2003 to 2006 were selected for the current study. Full-mouth periodontal status, measured as clinical attachment level (CAL), was recorded at baseline and in follow-up examinations. Development of periodontal disease was considered to be >= 2 teeth demonstrating a longitudinal loss of proximal attachment of >= 3 mm at the follow-up dental examination. A multivariable Poisson regression model with robust error variance was used to evaluate the association of MetS defined by the modified National Cholesterol Education Program Adult Treatment Panel III criteria with development of periodontal disease. Adjustments for sex, income, education, smoking status, number of teeth at baseline, mean CAL at baseline, pattern of visits to a dentist, and brushing frequency were considered.
   Results: The prevalence of MetS was 21.6% (27/125). Study participants with MetS were approximately 2.6 times more likely to develop periodontal disease (adjusted relative risk 2.58, 95% confidence interval 1.17 to 5.67) after simultaneous adjustment for other covariates.
   Conclusions: These findings support the hypothesis that MetS may be a risk factor for periodontal disease in older Japanese individuals. Additional studies with larger, more diverse populations and more complete information are needed to substantiate the findings.
C1 [Iwasaki, Masanori] Kyushu Dent Univ, Div Community Oral Hlth Dev, Kitakyushu, Fukuoka 8038580, Japan.
   [Iwasaki, Masanori; Sato, Misuzu; Minagawa, Kumiko; Miyazaki, Hideo] Niigata Univ, Dept Oral Hlth Sci, Div Prevent Dent, Grad Sch Med & Dent Sci, Niigata, Japan.
   [Manz, Michael C.] Univ Michigan, Dept Cariol Restorat Sci & Endodont, Ann Arbor, MI 48109 USA.
   [Manz, Michael C.] Univ Michigan, Sch Dent, Ann Arbor, MI 48109 USA.
   [Yoshihara, Akihiro] Niigata Univ, Grad Sch Med & Dent Sci, Div Oral Sci Hlth Promot, Dept Oral Hlth & Welf, Niigata 95021, Japan.
C3 Kyushu Dental University; Niigata University; University of Michigan
   System; University of Michigan; University of Michigan System;
   University of Michigan; Niigata University
RP Iwasaki, M (corresponding author), Kyushu Dent Univ, Div Community Oral Hlth Dev, Kokurakita Ku, 2-6-1 Manazuru, Kitakyushu, Fukuoka 8038580, Japan.
EM r14iwasaki@fa.kyu-dent.ac.jp
RI Miyazaki, Hideo/ABC-3159-2020; Iwasaki, Masanori/HTM-9059-2023
OI Iwasaki, Masanori/0000-0002-5739-2936
FU Ministry of Health and Welfare of Japan [H10-Iryo-001, H13-Iryo-001,
   H16-Iryo-020];  [23792504];  [26861827]; Grants-in-Aid for Scientific
   Research [26861827] Funding Source: KAKEN
FX This work was supported by Grants-in-Aid from the Ministry of Health and
   Welfare of Japan (H10-Iryo-001, H13-Iryo-001, and H16-Iryo-020) and
   Grants-in-Aid for Young Scientists (B) (23792504 and 26861827). The
   authors report no conflicts of interest related to this study.
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NR 46
TC 25
Z9 29
U1 0
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-3492
EI 1943-3670
J9 J PERIODONTOL
JI J. Periodont.
PD APR
PY 2015
VL 86
IS 4
BP 491
EP 498
DI 10.1902/jop.2015.140398
PG 8
WC Dentistry, Oral Surgery & Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dentistry, Oral Surgery & Medicine
GA CE9ER
UT WOS:000352147200006
PM 25579498
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Kinnunen, ML
   Kokkonen, M
   Kaprio, J
   Pulkkinen, L
AF Kinnunen, ML
   Kokkonen, M
   Kaprio, J
   Pulkkinen, L
TI The associations of emotion regulation and dysregulation with the
   metabolic syndrome factor
SO JOURNAL OF PSYCHOSOMATIC RESEARCH
LA English
DT Article
DE metabolic syndrome; emotion regulation and dysregulation; subjective
   health
ID SELF-RATED HEALTH; INSULIN-RESISTANCE; GENDER-DIFFERENCES; CHRONIC
   STRESS; MORTALITY; EXPRESSION; MOOD; INTELLIGENCE; PERSONALITY;
   PREVALENCE
AB Objective: Emotion regulation has been associated with good, and dysregulation with poor subjective health; but it is unclear if emotion regulation is related to metabolic syndrome. Methods: Associations between the metabolic syndrome factor (systolic and diastolic blood pressure, waist circumference, high-density lipoprotein, triglycerides, and glucose), emotion regulation (the strategies of repair and maintenance, self-perceived emotion regulation) and dysregulation (emotional ambivalence); and subjective health (self-rated health and psychosomatic symptoms) were studied using a structural equation modelling (SEM) approach. The participants (96 women, 85 men) were drawn from the Jyvaskyla Longitudinal Study of Personality and Social Development (JYLS). Results: High repair was associated directly to the low metabolic syndrome factor, while high maintenance, high self-perceived emotion regulation, and low emotional ambivalence were related indirectly to the low metabolic syndrome factor through good subjective health. Conclusions: Successful emotion regulation may have an association not only with the subjective experience of health, but also with physiological regulation systems, leading to a reduced risk for metabolic syndrome. (c) 2005 Elsevier Inc. All rights reserved.
C1 Univ Jyvaskyla, Dept Psychol, FIN-40014 Jyvaskyla, Finland.
   Univ Helsinki, Helsinki, Finland.
   Nalt Publ Hlth Inst, Helsinki, Finland.
C3 University of Jyvaskyla; University of Helsinki
RP Univ Jyvaskyla, Dept Psychol, POB 35, FIN-40014 Jyvaskyla, Finland.
EM matja-liisa.kinnunen@psyka.jyu.fi
RI Kaprio, Jaakko/A-1820-2008
OI Pulkkinen, Lea/0000-0002-4290-6690; Kaprio, Jaakko/0000-0002-3716-2455
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NR 68
TC 32
Z9 37
U1 0
U2 12
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-3999
EI 1879-1360
J9 J PSYCHOSOM RES
JI J. Psychosomat. Res.
PD JUN
PY 2005
VL 58
IS 6
BP 513
EP 521
DI 10.1016/j.jpsychores.2005.02.004
PG 9
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 969TU
UT WOS:000232258500006
PM 16125518
DA 2025-06-11
ER

PT J
AU Varela, M
   Rodriguez, C
   Vigil, L
   Cirugeda, E
   Colas, A
   Vargas, B
AF Varela, Manuel
   Rodriguez, Carmen
   Vigil, Luis
   Cirugeda, Eva
   Colas, Ana
   Vargas, Borja
TI Glucose series complexity at the threshold of diabetes
SO JOURNAL OF DIABETES
LA English
DT Article
DE blood glucose; metabolic syndrome X; type 2 diabetes mellitus
ID METABOLIC SYNDROME; HEART-RATE; OXIDATIVE STRESS; DYNAMICS; VARIABILITY;
   FRACTALS; FLUCTUATIONS; PREDICTOR; MORTALITY; DISEASE
AB BackgroundOne of the earliest signs of dysfunction in a complex system is the simplification of its output. A well-accepted method to measure this phenomenon is detrended fluctuation analysis (DFA). Herein, we evaluated the usefulness of DFA at the threshold of type 2 diabetes mellitus (T2DM).
   MethodsWe report on the clinical and glucometric characteristics of a sample of 103 patients at increased risk of developing T2DM. All patients had HbA1c levels 5%-6.4% and met at least one of the following criteria: body mass index (BMI)>30kg/m(2), essential hypertension or a first-degree relative with T2DM. For each patient, a 24-h glucose time series was obtained, and the clinical and glucometric variables were compared.
   ResultsThere was a significant correlation between the number of National Cholesterol Education Program - Adult Treatment Panel (ATP III) metabolic syndrome (MS)-defining criteria and DFA (=0.231, P=0.019), and DFA differed significantly between patients meeting or not the ATP III definition of MS (1.443 vs 1.399, respectively; P=0.018). The DFA was not correlated with HbA1c. Depending on how it was calculated, the area under the log(Fn)approximate to log(n) curve correlated with HbA1c levels or the number of MS criteria. Conventional variability metrics (mean amplitude of glycemic excursions) did not differ between patients complying or not with the definition of MS.
   ConclusionsComplexity analysis is capable of detecting differences in variables related to the risk of developing T2DM and could be a useful tool to study the initial phases of glucoregulatory dysfunction leading to T2DM.
C1 [Varela, Manuel; Rodriguez, Carmen; Vigil, Luis; Colas, Ana; Vargas, Borja] Univ Hosp Mostoles, Dept Internal Med, C Rio Jucar S-N, Madrid 6648087, Spain.
   [Cirugeda, Eva] Univ Politecn Valencia, Comp Sci Dept DISCA, Alcoy, Spain.
C3 Hospital Universitario de Mostoles; Universitat Politecnica de Valencia
RP Varela, M (corresponding author), Univ Hosp Mostoles, Dept Internal Med, C Rio Jucar S-N, Madrid 6648087, Spain.
EM manuel.varela@salud.madrid.org
RI Cirugeda, Eva/AAH-2096-2019; Vargas, Borja/K-4297-2018; Colás,
   Ana/AFP-2489-2022; Vigil, Luis/C-6875-2016; Rodriguez-Castro,
   Carmen/C-5442-2016
OI Vargas, Borja/0000-0002-5553-8372; Vigil, Luis/0000-0001-7484-2911;
   Colas Herrera, Ana/0000-0003-2784-4150; Cirugeda Roldan, Eva
   M./0000-0002-0623-3652; Rodriguez-Castro, Carmen/0000-0003-4970-9187
FU Fondo de Investigacion Sanitaria, Ministerio de Sanidad y Consumo, Spain
   [11/00811]
FX The authors are grateful to Emilia Condes (Departamento de Estadistica,
   Universidad Europea) for data management and Manuel Lopez Jimenez and
   Emilio Garcia Delgado (Department of Internal Medicine, University
   Hospital of Mostoles) for patient referral. This study was supported by
   Grant 11/00811 from the Fondo de Investigacion Sanitaria, Ministerio de
   Sanidad y Consumo, Spain.
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NR 26
TC 6
Z9 6
U1 0
U2 10
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1753-0393
EI 1753-0407
J9 J DIABETES
JI J. Diabetes
PD MAR
PY 2015
VL 7
IS 2
BP 287
EP 293
DI 10.1111/1753-0407.12182
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA CA7WD
UT WOS:000349127200021
PM 24911946
DA 2025-06-11
ER

PT J
AU Rimes, RR
   Moura, AMD
   Lamego, MK
   de Sá, AS
   Manochio, J
   Paes, F
   Carta, MG
   Mura, G
   Wegner, M
   Budde, H
   Rocha, NBF
   Rocha, J
   Tavares, JMRS
   Arias-Carrión, O
   Nardi, AE
   Yuan, TF
   Machado, S
AF Rimes, Ridson Rosa
   de Souza Moura, Antonio Marcos
   Lamego, Murilo Khede
   de Sa Filho, Alberto Souza
   Manochio, Joao
   Paes, Flavia
   Carta, Mauro Giovanni
   Mura, Gioia
   Wegner, Mirko
   Budde, Henning
   Ferreira Rocha, Nuno Barbosa
   Rocha, Joana
   Tavares, Joao Manuel R. S.
   Arias-Carrion, Oscar
   Nardi, Antonio Egidio
   Yuan, Ti-Fei
   Machado, Sergio
TI Effects of Exercise on Physical and Mental Health, and Cognitive and
   Brain Functions in Schizophrenia: Clinical and Experimental Evidence
SO CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
LA English
DT Article
DE Brain activity; cognitive function; exercise; mental health;
   schizophrenia
ID METABOLIC SYNDROME; AEROBIC EXERCISE; YOGA THERAPY; MORTALITY; PROGRAM;
   PSYCHOPATHOLOGY; PERFORMANCE; MANAGEMENT; FITNESS; WEIGHT
AB Exercise promotes several health benefits, such as cardiovascular, musculoskeletal and cardiorespiratory improvements. It is believed that the practice of exercise in individuals with psychiatric disorders, e.g. schizophrenia, can cause significant changes. Schizophrenic patients have problematic lifestyle habits compared with general population; this may cause a high mortality rate, mainly caused by cardiovascular and metabolic diseases. Thus, the aim of this study is to investigate changes in physical and mental health, cognitive and brain functioning due to the practice of exercise in patients with schizophrenia. Although still little is known about the benefits of exercise on mental health, cognitive and brain functioning of schizophrenic patients, exercise training has been shown to be a beneficial intervention in the control and reduction of disease severity. Type of training, form of execution, duration and intensity need to be better studied as the effects on physical and mental health, cognition and brain activity depend exclusively of interconnected factors, such as the combination of exercise and medication. However, one should understand that exercise is not only an effective non-drug alternative, but also acts as a supporting linking up interventions to promote improvements in process performance optimization. In general, the positive effects on mental health, cognition and brain activity as a result of an exercise program are quite evident. Few studies have been published correlating effects of exercise in patients with schizophrenia, but there is increasing evidence that positive and negative symptoms can be improved. Therefore, it is important that further studies be undertaken to expand the knowledge of physical exercise on mental health in people with schizophrenia, as well as its dose-response and the most effective type of exercise.
C1 [Rimes, Ridson Rosa; de Souza Moura, Antonio Marcos; Lamego, Murilo Khede; de Sa Filho, Alberto Souza; Manochio, Joao; Paes, Flavia; Nardi, Antonio Egidio; Machado, Sergio] Univ Fed Rio de Janeiro, Inst Psychiat, Lab Pan & Respirat, Rio De Janeiro, Brazil.
   [Carta, Mauro Giovanni; Mura, Gioia] Univ Cagliari, Dept Publ Hlth Clin & Mol Med, Cagliari, Italy.
   [Wegner, Mirko] Univ Bern, Inst Sport Sci, Bern, Switzerland.
   [Budde, Henning] Med Sch Hamburg, Fac Human Sci, Hamburg, Germany.
   [Budde, Henning] Reykjavik Univ, Sch Sci & Engn, Dept Sport Sci, Reykjavik, Iceland.
   [Ferreira Rocha, Nuno Barbosa] Polytech Inst Porto, Sch Allied Hlth Sci, Oporto, Portugal.
   [Rocha, Joana] Univ Fernando Pessoa, Oporto, Portugal.
   [Tavares, Joao Manuel R. S.] Univ Porto, Fac Engn, Dept Engn Mecan, Inst Engn Mecan & Gestao Ind, P-4100 Oporto, Portugal.
   [Arias-Carrion, Oscar] Hosp Gen Dr Manuel Gea Gonzalez, Unidad Trastornos Movimiento & Sueno TMS, Mexico City, DF, Mexico.
   [Arias-Carrion, Oscar] Hosp Gen Ajusco Medio, Unidad Trastornos Movimiento & Sueno TMS, Mexico City, DF, Mexico.
   [Yuan, Ti-Fei] Nanjing Normal Univ, Sch Psychol, Nanjing, Jiangsu, Peoples R China.
   [Machado, Sergio] Univ Salgado de Oliveira, Phys Act Sci Postgrad Program, Phys Act Neurosci, Niteroi, RJ, Brazil.
C3 Universidade Federal do Rio de Janeiro; University of Cagliari;
   University of Bern; University of Hamburg; MSH Medical School Hamburg;
   Reykjavik University; Instituto Politecnico do Porto; Universidade
   Fernando Pessoa; Universidade do Porto; Nanjing Normal University;
   Universidade Salgado de Oliveira
RP Yuan, TF (corresponding author), Nanjing Normal Univ, Sch Psychol, Nanjing, Jiangsu, Peoples R China.
EM ytf0707@126.com; secm80@gmail.com
RI Sá Filho, Alberto/C-2663-2015; Arias-Carrion, Oscar/A-4248-2018; Yuan,
   Ti-Fei/LCD-4217-2024; Budde, Henning/AFB-9845-2022; Rocha,
   Joana/AAU-6676-2021; Carta, MauroGiovanni/D-9624-2012; Nardi,
   Antonio/A-7335-2014; Wegner, Mirko/AAT-1758-2020; Rocha,
   Nuno/M-9821-2013; Tavares, Joao/M-5305-2013; Machado, Sergio/M-9384-2013
OI Rocha, Nuno/0000-0002-3139-2786; Tavares, Joao/0000-0001-7603-6526;
   Rocha, Joana/0000-0002-4124-340X; Sa Filho, Alberto/0000-0001-9434-4231;
   Machado, Sergio/0000-0001-8946-8467; Budde, Henning/0000-0003-3526-0569;
   Arias-Carrion, Oscar/0000-0002-9982-7571
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NR 60
TC 29
Z9 36
U1 2
U2 78
PU BENTHAM SCIENCE PUBL
PI BUSUM
PA PO BOX 294, BUSUM, 1400 AG, NETHERLANDS
SN 1871-5273
EI 1996-3181
J9 CNS NEUROL DISORD-DR
JI CNS Neurol. Disord.-Drug Targets
PY 2015
VL 14
IS 10
BP 1244
EP 1254
DI 10.2174/1871527315666151111130659
PG 11
WC Neurosciences; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Pharmacology & Pharmacy
GA CX6JW
UT WOS:000365808000001
PM 26556069
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Yehuda, H
   Madrer, N
   Goldberg, D
   Soreq, H
   Meerson, A
AF Yehuda, Hila
   Madrer, Nimrod
   Goldberg, Doron
   Soreq, Hermona
   Meerson, Ari
TI Inversely Regulated Inflammation-Related Processes Mediate
   Anxiety-Obesity Links in Zebrafish Larvae and Adults
SO CELLS
LA English
DT Article
DE anxiety; antagonistic pleiotropy; caffeine; high-fat diet; immune
   system; obesity; noncoding RNA; RNA sequencing; transfer RNA fragments;
   zebrafish
ID HIGH-FAT DIET; METABOLIC SYNDROME; ADIPOSE-TISSUE; BEHAVIORAL-RESPONSES;
   DANIO-RERIO; EXPRESSION; DISORDERS; CAFFEINE; PROTECTS; STRESS
AB Anxiety and metabolic impairments are often inter-related, but the underlying mechanisms are unknown. To seek RNAs involved in the anxiety disorder-metabolic disorder link, we subjected zebrafish larvae to caffeine-induced anxiety or high-fat diet (HFD)-induced obesity followed by RNA sequencing and analyses. Notably, differentially expressed (DE) transcripts in these larval models and an adult zebrafish caffeine-induced anxiety model, as well as the transcript profiles of inherently anxious versus less anxious zebrafish strains and high-fat diet-fed versus standard diet-fed adult zebrafish, revealed inversely regulated DE transcripts. In both larval anxiety and obesity models, these included long noncoding RNAs and transfer RNA fragments, with the overrepresented immune system and inflammation pathways, e.g., the "interleukin signaling pathway" and "inflammation mediated by chemokine and cytokine signaling pathway". In adulthood, overrepresented immune system processes included "T cell activation", "leukocyte cell-cell adhesion", and "antigen processing and presentation". Furthermore, unlike adult zebrafish, obesity in larvae was not accompanied by anxiety-like behavior. Together, these results may reflect an antagonistic pleiotropic phenomenon involving a re-adjusted modulation of the anxiety-metabolic links with an occurrence of the acquired immune system. Furthermore, the HFD potential to normalize anxiety-upregulated immune-related genes may reflect the high-fat diet protection of anxiety and neurodegeneration reported by others.
C1 [Yehuda, Hila; Goldberg, Doron; Meerson, Ari] Galilee Res Inst, MIGAL, IL-11016 Kiryat Shmona, Israel.
   [Yehuda, Hila; Madrer, Nimrod; Soreq, Hermona] Hebrew Univ Jerusalem, Alexander Silberman Inst Life Sci, IL-9190401 Jerusalem, Israel.
   [Madrer, Nimrod; Soreq, Hermona] Hebrew Univ Jerusalem, Edmond & Lily Safra Ctr Brain Sci, IL-9190401 Jerusalem, Israel.
   [Goldberg, Doron; Meerson, Ari] Tel Hai Coll, IL-1220800 Upper Galilee, Israel.
C3 Hebrew University of Jerusalem; Hebrew University of Jerusalem; Tel Hai
   Academic College
RP Meerson, A (corresponding author), Galilee Res Inst, MIGAL, IL-11016 Kiryat Shmona, Israel.; Soreq, H (corresponding author), Hebrew Univ Jerusalem, Alexander Silberman Inst Life Sci, IL-9190401 Jerusalem, Israel.; Soreq, H (corresponding author), Hebrew Univ Jerusalem, Edmond & Lily Safra Ctr Brain Sci, IL-9190401 Jerusalem, Israel.; Meerson, A (corresponding author), Tel Hai Coll, IL-1220800 Upper Galilee, Israel.
EM dorongo@telhai.ac.il; hermona.soreq@mail.huji.ac.il; arim@migal.org.il
RI Soreq, Hermona/AFM-0869-2022; Meerson, Ari/N-2338-2019
OI Soreq, Hermona/0000-0002-0955-526X; Meerson, Ari/0000-0002-5811-7952
FU Israel Science Foundation [1016/18]; internal MIGAL grant
FX This study was supported by the Israel Science Foundation award (grant
   number 1016/18) to H.S. and an internal MIGAL grant to A.M.
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NR 139
TC 2
Z9 2
U1 1
U2 18
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2073-4409
J9 CELLS-BASEL
JI Cells
PD JUL
PY 2023
VL 12
IS 13
AR 1794
DI 10.3390/cells12131794
PG 32
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA M6DR1
UT WOS:001031107600001
PM 37443828
OA Green Submitted, gold, Green Published
DA 2025-06-11
ER

PT J
AU Beyer, JL
   Payne, ME
AF Beyer, John L.
   Payne, Martha E.
TI Nutrition and Bipolar Depression
SO PSYCHIATRIC CLINICS OF NORTH AMERICA
LA English
DT Article
DE Bipolar depression; Diet; Nutrition; Omega-3 fatty acids;
   N-acetylcysteine; Vitamin D; Mediterranean diet
ID N-ACETYL CYSTEINE; MEDITERRANEAN DIETARY PATTERN; POLYUNSATURATED
   FATTY-ACIDS; COMMON MENTAL-DISORDERS; ADD-ON TREATMENT; KETOGENIC DIET;
   NEUROTROPHIC FACTOR; METABOLIC SYNDROME; CONTROLLED-TRIAL; ADULTS
AB As with physical conditions, bipolar disorder is likely to be impacted by diet and nutrition. Patients with bipolar disorder have been noted to have relatively unhealthy diets, which may in part be the reason they also have an elevated risk of metabolic syndrome and obesity. An improvement in the quality of the diet should improve a bipolar patient's overall health risk profile, but it may also improve their psychiatric outcomes. New insights into biological dysfunctions that may be present in bipolar disorder have presented new theoretic frameworks for understanding the relationship between diet and bipolar disorder.
C1 [Beyer, John L.] Duke Univ, Med Ctr, Duke South Clin, Box 3519 DUMC,Room 4082B, Durham, NC 27710 USA.
   [Payne, Martha E.] Duke Univ, Sch Med, Off Res Dev, Davison Bldg Green Zone,Suite 410, Durham, NC 27705 USA.
C3 Duke University; Duke University
RP Beyer, JL (corresponding author), Duke Univ, Med Ctr, Duke South Clin, Box 3519 DUMC,Room 4082B, Durham, NC 27710 USA.
EM john.beyer@dm.duke.edu
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NR 81
TC 23
Z9 25
U1 1
U2 68
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0193-953X
EI 1558-3147
J9 PSYCHIAT CLIN N AM
JI Psychiatr. Clin. North Amer.
PD MAR
PY 2016
VL 39
IS 1
BP 75
EP +
DI 10.1016/j.psc.2015.10.003
PG 13
WC Psychiatry
WE Social Science Citation Index (SSCI)
SC Psychiatry
GA DH8GV
UT WOS:000373032400006
PM 26876319
DA 2025-06-11
ER

PT J
AU Khalil, SS
   Ahmed, AI
   Mohammed, NA
   El-Naggar, AA
   Ali, HA
   Al-Saadawy, HA
   Ahmad, KRE
AF Khalil, Samah S.
   Ahmed, Amany I.
   Mohammed, Nada A.
   El-Naggar, Azza A.
   Ali, Haytham A.
   Al-Saadawy, Hamad A.
   Ahmad, Khalifa R. E.
TI A REVIEW ON METABOLIC SYNDOME: BIOCHEMICAL INVESTIGATIONS
SO SLOVENIAN VETERINARY RESEARCH
LA English
DT Article; Proceedings Paper
CT 3rd International Conference on Veterinary Medicine In-Between Health
   and Economy (VMHE)
CY OCT 16-19, 2018
CL Zagazig Univ, Hurghada, EGYPT
HO Zagazig Univ
DE metabolic syndrome; diabetes mellitus; insulin resistance; obesity
ID INTERNATIONAL-DIABETES-FEDERATION; NUTRITION-EXAMINATION-SURVEY; INDUCED
   INSULIN-RESISTANCE; CORONARY-HEART-DISEASE; CARDIOVASCULAR-DISEASE;
   OXIDATIVE STRESS; RISK-FACTORS; PROVISIONAL REPORT; BODY-COMPOSITION;
   NATIONAL-HEALTH
AB In the last few years, the metabolic syndrome (MetS) has attracted increased attention. Metabolic syndrome defined as a group of interconnected biochemical, physiological, metabolic and clinical risk factors such as hypertension, obesity, glucose intolerance, dyslipidemia and inflammation that lead to many fatal diseases as atherosclerotic cardiovascular disease, stroke and type 2 diabetes mellitus. This review tends to go over the main points of the essential mechanisms involved in induction models of MetS by diet regimen based on high-fat high fructose/sucrose (HFHF) added to normal chow. Management of metabolic syndrome should undergo several axes such as increasing physical activity, modification of lifestyle and healthy food besides. Moreover, medications can be used to control the symptoms of different disease related to metabolic syndrome. Finally, we can conclude that the main and prevalent risk factors for the pathophysiology of Metabolic Syndrome are Insulin resistant, abdominal obesity. Also, physical inactivity and chronic inflammation which provide a possible explanation of the cause of the metabolic syndrome until now which designates the energetic relationship between a number of contributing factors.
C1 [Khalil, Samah S.; Ahmed, Amany I.; Mohammed, Nada A.; El-Naggar, Azza A.; Ali, Haytham A.; Al-Saadawy, Hamad A.; Ahmad, Khalifa R. E.] Zagazig Univ, Fac Vet Med, Biochem Dept, Zagazig 44511, Egypt.
   [Khalil, Samah S.] Zagazig Univ, Zagazig Univ Hosp, Zagazig, Egypt.
   [Ali, Haytham A.] Univ Jeddah, Biochem Dept, Fac Sci, Jeddah, Saudi Arabia.
C3 Egyptian Knowledge Bank (EKB); Zagazig University; Egyptian Knowledge
   Bank (EKB); Zagazig University; University of Jeddah
RP Khalil, SS (corresponding author), Zagazig Univ, Fac Vet Med, Biochem Dept, Zagazig 44511, Egypt.; Khalil, SS (corresponding author), Zagazig Univ, Zagazig Univ Hosp, Zagazig, Egypt.
EM samahsaid75@gmail.com
RI Ali, Haytham/AAJ-5827-2020
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NR 110
TC 0
Z9 0
U1 0
U2 8
PU UNIV LJUBLJANA
PI LJUBLJANA
PA University of Ljubljana Press (University of Ljubljana), Kongresni trg
   12, LJUBLJANA, SLOVENIA
SN 1580-4003
EI 2385-8761
J9 SLOV VET RES
JI Slov. Vet. Res.
PY 2018
VL 55
SU 20
BP 427
EP 443
DI 10.26873/SVR-670-2018
PG 17
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Veterinary Sciences
GA HD4JF
UT WOS:000452492700041
DA 2025-06-11
ER

PT J
AU Pistelli, M
   Natalucci, V
   Scortichini, L
   Agostinelli, V
   Lenci, E
   Crocetti, S
   Merloni, F
   Bastianelli, L
   Taus, M
   Fumelli, D
   Giulietti, G
   Cola, C
   Capecci, M
   Serrani, R
   Ceravolo, MG
   Ricci, M
   Nicolai, A
   Barbieri, E
   Nicolai, G
   Ballatore, Z
   Savini, A
   Berardi, R
AF Pistelli, Mirco
   Natalucci, Valentina
   Scortichini, Laura
   Agostinelli, Veronica
   Lenci, Edoardo
   Crocetti, Sonia
   Merloni, Filippo
   Bastianelli, Lucia
   Taus, Marina
   Fumelli, Daniele
   Giulietti, Gloria
   Cola, Claudia
   Capecci, Marianna
   Serrani, Roberta
   Ceravolo, Maria Gabriella
   Ricci, Maurizio
   Nicolai, Albano
   Barbieri, Elena
   Nicolai, Giulia
   Ballatore, Zelmira
   Savini, Agnese
   Berardi, Rossana
TI The Impact of Lifestyle Interventions in High-Risk Early Breast Cancer
   Patients: A Modeling Approach from a Single Institution Experience
SO CANCERS
LA English
DT Article
DE lifestyle; physical activity; Mediterranean diet; obesity; metabolic
   syndrome; anxiety; early breast cancer
ID PHYSICAL-ACTIVITY; METABOLIC SYNDROME; JOINT SYMPTOMS; SURVIVORS;
   EXERCISE; PREVALENCE; THERAPY; WOMEN
AB Simple Summary: High body mass index (BMI) is correlated with an increased production of hormones (estrogens, insulin, testosterone, leptin), and pro-inflammatory cytokines, which have been associated with breast cancer (BC) risk and recurrence. Regular physical activity (PA) decreases BMI and blood concentrations of testosterone, estrogens, insulin and pro-inflammatory cytokines. Moreover, the Mediterranean diet (MD) reduces obesity, metabolic syndrome (MS) and insulin resistance, which are all associated with increased risk of BC onset and recurrence. Despite the accumulating evidence of the detrimental effect of physical inactivity and overweight on BC recurrence, weight control and PA counseling are not yet current practice. The principal aim of the lifestyle intervention is to promote weight loss through diet and physical activity in overweight and/or high-risk breast cancer survivors. Moreover, implementing a "lifestyle interventions program" in clinical practice can lead to improvements in psychophysical well-being and favor the correction of cardiovascular risk factors and compliance with endocrine therapy, potentially translating into a prognostic advantage.A healthy lifestyle plays a strategic role in the prevention of BC. The aim of our prospective study is to evaluate the effects of a lifestyle interventions program based on special exercise and nutrition education on weight, psycho-physical well-being, blood lipid and hormonal profile among BC patients who underwent primary surgery. From January 2014 to March 2017, a multidisciplinary group of oncologists, dieticians, physiatrists and an exercise specialist evaluated 98 adult BC female patients at baseline and at different time points. The patients had at least one of the following risk factors: BMI & GE; 25 kg/m(2), high testosterone levels, high serum insulin levels or diagnosis of MS. Statistically significant differences are shown in terms of BMI variation with the lifestyle interventions program, as well as in waist circumference and blood glucose, insulin and testosterone levels. Moreover, a statistically significant difference was reported in variations of total Hospital Anxiety and Depression Scale (HADS) score, in the anxiety HADS score and improvement in joint pain. Our results suggested that promoting a healthy lifestyle in clinical practice reduces risk factors involved in BC recurrence and ensures psycho-physical well-being.
C1 [Pistelli, Mirco; Scortichini, Laura; Agostinelli, Veronica; Lenci, Edoardo; Crocetti, Sonia; Merloni, Filippo; Bastianelli, Lucia; Ballatore, Zelmira; Savini, Agnese; Berardi, Rossana] Univ Politecn Marche, AOU Osped Riuniti Ancona, Dept Med Oncol, I-60126 Ancona, Italy.
   [Natalucci, Valentina; Barbieri, Elena] Univ Urbino Carlo Bo, Dept Biomol Sci, I-61029 Urbino, Italy.
   [Taus, Marina; Fumelli, Daniele; Giulietti, Gloria; Cola, Claudia; Nicolai, Albano] AOU Osped Riuniti Ancona, Dietol & Clin Nutr, I-60126 Ancona, Italy.
   [Capecci, Marianna; Ceravolo, Maria Gabriella] Univ Politecn Marche, Dept Expt & Clin Med, AOU Osped Riuniti Ancona, Neurorehabil Clin, I-60126 Ancona, Italy.
   [Serrani, Roberta; Ricci, Maurizio] AOU Osped Riuniti Ancona, Div Rehabil Med, I-60126 Ancona, Italy.
   [Nicolai, Giulia] AOU Osped Riuniti Marche Nord, Dept Med Emergency, I-61121 Pesaro, Italy.
C3 Marche Polytechnic University; University of Urbino; Marche Polytechnic
   University
RP Pistelli, M; Berardi, R (corresponding author), Univ Politecn Marche, AOU Osped Riuniti Ancona, Dept Med Oncol, I-60126 Ancona, Italy.
EM mirco.pistelli@ospedaliriuniti.marche.it; valentina.natalucci@uniurb.it;
   laura_sco@libero.it; veroagostinelli@gmail.com;
   lenci@ospedaliriuniti.marche.it; crocetti.sonia@alice.it;
   merloni.filippo@gmail.com; lucia.bastianelli@ospedaliriuniti.marche.it;
   marina.taus@ospedaliriuniti.marche.it;
   daniele.fumelli@ospedaliriuniti.marche.it;
   gloria.giulietti@ospedaliriuniti.marche.it;
   claudia.cola@ospedaliriuniti.marche.it;
   marianna.capecci@ospedaliriuniti.marche.it;
   roberta.serrani@ospedaliriuniti.marchelt;
   MariaGabriella.Ceravolo@ospedaliriuniti.marche.it;
   maurizio.ricd@ospedaliriuniti.marche.it;
   albano.nicolai@ospedaliriuniti.marche.it; elena.barbieri@uniurb.it;
   giulia.nicolai@ospedalimarchenord.it;
   zelmira.ballatore@ospedaliriuniti.marche.it;
   agnese.savini@ospedaliriuniti.marche.it; r.berardi@univpm.it
RI Ceravolo, Maria/J-7385-2018; Berardi, Rossana/AAC-5758-2022; Capecci,
   Marianna/AFL-2394-2022; Natalucci, Valentina/AAM-7882-2020; Barbieri,
   Elena/AGI-0430-2022
OI Natalucci, Valentina/0000-0002-0582-1575; Capecci,
   Marianna/0000-0002-1472-606X; AGOSTINELLI, VERONICA/0000-0002-9410-1528;
   Pistelli, Mirco/0000-0002-9289-8537; Berardi,
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NR 47
TC 12
Z9 12
U1 1
U2 8
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6694
J9 CANCERS
JI Cancers
PD NOV
PY 2021
VL 13
IS 21
AR 5539
DI 10.3390/cancers13215539
PG 16
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA WY4WR
UT WOS:000719279700001
PM 34771702
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Acosta-Castro, P
   Hirotsu, C
   Marti-Soler, H
   Marques-Vidal, P
   Tobback, N
   Andries, D
   Waeber, G
   Preisig, M
   Vollenweider, P
   Haba-Rubio, J
   Heinzer, R
AF Acosta-Castro, Patricia
   Hirotsu, Camila
   Marti-Soler, Helena
   Marques-Vidal, Pedro
   Tobback, Nadia
   Andries, Daniela
   Waeber, Gerard
   Preisig, Martin
   Vollenweider, Peter
   Haba-Rubio, Jose
   Heinzer, Raphael
TI REM-associated sleep apnoea: prevalence and clinical significance in the
   HypnoLaus cohort
SO EUROPEAN RESPIRATORY JOURNAL
LA English
DT Article
ID EYE-MOVEMENT SLEEP; QUALITY-OF-LIFE; POSITIVE AIRWAY PRESSURE; DAYTIME
   SLEEPINESS; GLYCEMIC CONTROL; GLUCOSE-METABOLISM; POPULATION;
   HYPERTENSION; DEPRESSION; DISORDERS
AB This study determined the prevalence of rapid eye movement (REM) related sleepdisordered breathing (REM-SDB) in the general population and investigated the associations of REM-SDB with hypertension, metabolic syndrome, diabetes and depression.
   Home polysomnography (PSG) recordings (n=2074) from the population-based HypnoLaus Sleep Cohort (48.3% men, 57 +/- 11 years old) were analysed. The apnoea-hypopnoea index was measured during REM and non-REM sleep (as REM-AHI and NREM-AHI, respectively). Regression models were used to explore the associations between REM-SDB and hypertension, diabetes, metabolic syndrome and depression in the entire cohort and in subgroups with NREM-AHI <10 events.h(-1) and total AHI <10 events.h(-1).
   The prevalence of REM-AHI >= 20 events-h(-1) was 40.8% in the entire cohort. An association between increasing REM-AHI and metabolic syndrome was found in the entire cohort and in both the NREM-AHI and AHI subgroups (p-trend=0.014, <0.0001 and 0.015, respectively). An association was also found between REM-AHI >= 20 events.h(-1) and diabetes in both the NREM-AHI <10 events.h(-1) (odds ratio (OR) 3.12 (95% CI 1.35-7.20)) and AHI <10 events.h(-1) (OR 2.92 (95% CI 1.12-7.63)) subgroups. Systolic and diastolic blood pressure were positively associated with REM-AHI >= 20 events.11 -1 .
   REM-SDB is highly prevalent in our middle-to-older age sample and is independently associated with metabolic syndrome and diabetes. These findings suggest that an increase in REM-AHI could be clinically relevant.
C1 [Acosta-Castro, Patricia; Hirotsu, Camila; Tobback, Nadia; Andries, Daniela; Haba-Rubio, Jose; Heinzer, Raphael] Univ Hosp Lausanne, CIRS, Lausanne, Switzerland.
   [Acosta-Castro, Patricia] Univ Hosp Ramon Y Cajal, Pulm Dept, Madrid, Spain.
   [Marti-Soler, Helena] Univ Hosp Lausanne, Inst Social & Prevent Med, Lausanne, Switzerland.
   [Marques-Vidal, Pedro; Waeber, Gerard; Vollenweider, Peter] Univ Hosp Lausanne, Dept Internal Med, Lausanne, Switzerland.
   [Preisig, Martin] Univ Hosp Lausanne, Psychiat Dept, Lausanne, Switzerland.
C3 University of Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV);
   Hospital Universitario Ramon y Cajal; University of Lausanne; Centre
   Hospitalier Universitaire Vaudois (CHUV); University of Lausanne; Centre
   Hospitalier Universitaire Vaudois (CHUV); University of Lausanne; Centre
   Hospitalier Universitaire Vaudois (CHUV)
RP Heinzer, R (corresponding author), Univ Hosp Lausanne, Ctr Invest & Res Sleep, Pulm Dept, CH-1011 Lausanne, Switzerland.; Heinzer, R (corresponding author), Lausanne Univ, CH-1011 Lausanne, Switzerland.
EM raphael.heinzer@chuv.ch
RI Marti-Soler, Helena/AAA-7659-2019; Preisig, Martin/H-3441-2016; Hirotsu,
   Camila/C-1960-2013; Vollenweider, Peter/Q-4603-2016; Marques-Vidal,
   Pedro/C-9449-2009
OI Marti-Soler, Helena/0000-0002-7127-205X; Vollenweider,
   Peter/0000-0002-0765-896X; Waeber, Gerard/0000-0003-4193-788X; Heinzer,
   Raphael/0000-0002-3215-7788; Hirotsu, Camila/0000-0002-6760-0663;
   Marques-Vidal, Pedro/0000-0002-4548-8500; Preisig,
   Martin/0000-0001-5689-4259
FU Faculty of Biology and Medicine of Lausanne University; Lausanne
   University Hospital (CHUV); Leenaards Foundation; Ligue Pulmonaire
   Vaudoise; Swiss National Science Foundation; GlaxoSmithKline; Crossref
   Funder Registry
FX The Faculty of Biology and Medicine of Lausanne University, the Lausanne
   University Hospital (CHUV), the Leenaards Foundation and the Ligue
   Pulmonaire Vaudoise funded the salary of the technicians who did the
   sleep recordings. The Swiss National Science Foundation funded the
   statisticians and supported the initial CoLaus/PsyCoLaus cohort.
   GlaxoSmithKline supported the initial CoLaus/PsyCoLaus cohort and funded
   the polysomnography recorders. The funders of the study had no role in
   study design, data collection, data analysis, data interpretation, or
   writing of the report. The corresponding author had full access to all
   data in the study and had final responsibility for the decision to
   submit for publication. Funding information for this article has been
   deposited with the Crossref Funder Registry.
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NR 50
TC 48
Z9 51
U1 1
U2 8
PU EUROPEAN RESPIRATORY SOC JOURNALS LTD
PI SHEFFIELD
PA 442 GLOSSOP RD, SHEFFIELD S10 2PX, ENGLAND
SN 0903-1936
EI 1399-3003
J9 EUR RESPIR J
JI Eur. Resp. J.
PD AUG 1
PY 2018
VL 52
IS 2
AR 1702484
DI 10.1183/13993003.02484-2017
PG 12
WC Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Respiratory System
GA GX8XE
UT WOS:000448078200004
PM 29976653
OA Bronze, Green Accepted
DA 2025-06-11
ER

PT J
AU Nabavi, SF
   Habtemariam, S
   Di Lorenzo, A
   Sureda, A
   Khanjani, S
   Nabavi, SM
   Daglia, M
AF Nabavi, Seyed Fazel
   Habtemariam, Solomon
   Di Lorenzo, Arianna
   Sureda, Antoni
   Khanjani, Sedigheh
   Nabavi, Seyed Mohammad
   Daglia, Maria
TI Post-Stroke Depression Modulation and in Vivo Antioxidant
   Activity of Gallic Acid and Its Synthetic Derivatives in a Murine Model
   System
SO NUTRIENTS
LA English
DT Article
DE depression; gallic acid; ischemia; stroke
ID INDUCED OXIDATIVE STRESS; CHRONIC CEREBRAL HYPOPERFUSION;
   ANTIDEPRESSANT-LIKE ACTIVITY; METHYL-3-O-METHYL GALLATE;
   PELTIPHYLLUM-PELTATUM; BRAIN; RATS; CELLS; ERYTHROCYTES; POLYPHENOLS
AB Gallic acid (3,4,5-trihydroxybenzoic acid, GA) is a plant secondary metabolite, which shows antioxidant activity and is commonly found in many plant-based foods and beverages. Recent evidence suggests that oxidative stress contributes to the development of many human chronic diseases, including cardiovascular and neurodegenerative pathologies, metabolic syndrome, type 2 diabetes and cancer. GA and its derivative, methyl-3-O-methyl gallate (M3OMG), possess physiological and pharmacological activities closely related to their antioxidant properties. This paper describes the antidepressive-like effects of intraperitoneal administration of GA and two synthetic analogues, M3OMG and P3OMG (propyl-3-O-methylgallate), in balb/c mice with post-stroke depression, a secondary form of depression that could be due to oxidative stress occurring during cerebral ischemia and the following reperfusion. Moreover, this study determined the in vivo antioxidant activity of these compounds through the evaluation of superoxide dismutase (SOD) and catalase (Cat) activity, thiobarbituric acid-reactive substances (TBARS) and reduced glutathione (GSH) levels in mouse brain. GA and its synthetic analogues were found to be active (at doses of 25 and 50 mg/kg) in the modulation of depressive symptoms and the reduction of oxidative stress, restoring normal behavior and, at least in part, antioxidant endogenous defenses, with M3OMG being the most active of these compounds. SOD, TBARS, and GSH all showed strong correlation with behavioral parameters, suggesting that oxidative stress is tightly linked to the pathological processes involved in stroke and PSD. As a whole, the obtained results show that the administration of GA, M3OMG and P3OMG induce a reduction in depressive symptoms and oxidative stress.
C1 [Nabavi, Seyed Fazel; Nabavi, Seyed Mohammad] Baqiyatallah Univ Med Sci, Appl Biotechnol Res Ctr, POB 19395-5487, Tehran 193955487, Iran.
   [Habtemariam, Solomon] Univ Greenwich, Pharmacognosy Res Labs, Medway Sch Sci, Chatham ME4 4TB, Kent, England.
   [Di Lorenzo, Arianna; Daglia, Maria] Univ Pavia, Med Chem & Pharmaceut Technol Sect, Dept Drug Sci, Viale Taramelli 12, I-27100 Pavia, Italy.
   [Sureda, Antoni] Univ Illes Balears, Grp Nutr Comunitaria & Estres Oxidatiu IUNICS, E-07122 Palma De Mallorca, Spain.
   [Sureda, Antoni] Univ Illes Balears, CIBEROBN Physiopathol Obes & Nutr, E-07122 Palma De Mallorca, Spain.
   [Khanjani, Sedigheh] Shahid Behshti Univ, Fac Biol Sci, Dept Physiol, POB 19615-1178, Tehran 196151178, Iran.
C3 Baqiyatallah University of Medical Sciences (BMSU); University of
   Greenwich; University of Pavia; Universitat de les Illes Balears;
   Universitat de les Illes Balears; CIBER - Centro de Investigacion
   Biomedica en Red; CIBEROBN; Shahid Beheshti University
RP Daglia, M (corresponding author), Univ Pavia, Med Chem & Pharmaceut Technol Sect, Dept Drug Sci, Viale Taramelli 12, I-27100 Pavia, Italy.
EM Nabavisf@gmail.com; s.habtemariam@herbalanalysis.co.uk;
   arianna.dilorenzo01@universitadipavia.it; tosugo@hotmail.com;
   s.khanjani66@yahoo.com; Nabavi208@gmail.com; maria.daglia@unipv.it
RI Nabavi, Seyed Mohammad/G-5335-2010; Sureda, Antoni/N-9588-2019; Daglia,
   Maria/AAC-9498-2019; nabavi, seyed fazel/A-2223-2010
OI Daglia, Maria/0000-0002-4870-7713; , Antoni/0000-0001-8656-6838
FU Spanish Ministry of Health and Consumer Affairs [CIBEROBN CB12/03/30038]
FX Antoni Sureda was supported by Spanish Ministry of Health and Consumer
   Affairs (CIBEROBN CB12/03/30038). We thank the EPSRC National Mass
   Spectrometry Facility (Singleton Park, Swansea, UK) for acquiring the MS
   data.
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NR 36
TC 68
Z9 71
U1 0
U2 28
PU MDPI AG
PI BASEL
PA POSTFACH, CH-4005 BASEL, SWITZERLAND
SN 2072-6643
J9 NUTRIENTS
JI Nutrients
PD MAY
PY 2016
VL 8
IS 5
AR 248
DI 10.3390/nu8050248
PG 13
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA DP8XI
UT WOS:000378780900009
PM 27136579
OA Green Published, Green Accepted, gold
DA 2025-06-11
ER

PT J
AU Dasuri, K
   Ebenezer, P
   Fernandez-Kim, SO
   Zhang, L
   Gao, ZG
   Bruce-Keller, AJ
   Freeman, LR
   Keller, JN
AF Dasuri, Kalavathi
   Ebenezer, Philip
   Fernandez-Kim, Sun Ok
   Zhang, Le
   Gao, Zhanguo
   Bruce-Keller, Annadora J.
   Freeman, Linnea R.
   Keller, Jeffrey N.
TI Role of physiological levels of 4-hydroxynonenal on adipocyte biology:
   implications for obesity and metabolic syndrome
SO FREE RADICAL RESEARCH
LA English
DT Article
DE adipose; adipogenesis; Insulin resistance; diabetes; metabolic syndrome;
   obesity; oxidative stress
ID OXIDATIVE STRESS; INSULIN-RESISTANCE; ADIPOSE-TISSUE; 3T3-L1 ADIPOCYTES;
   PPAR-GAMMA; PHOSPHATIDYLINOSITOL 3-KINASE; GLUT4 TRANSLOCATION;
   LIPID-PEROXIDATION; ANATOMIC SITE; FATTY-ACIDS
AB Lipid peroxidation products such as 4-hydroxynonenal (HNE) are known to be increased in response to oxidative stress, and are known to cause dysfunction and pathology in a variety of tissues during periods of oxidative stress. The aim of the current study was to determine the chronic (repeated HNE exposure) and acute effects of physiological concentrations of HNE toward multiple aspects of adipocyte biology using differentiated 3T3-L1 adipocytes. Our studies demonstrate that acute and repeated exposure of adipocytes to physiological concentrations of HNE is sufficient to promote subsequent oxidative stress, impaired adipogenesis, alter the expression of adipokines, and increase lipolytic gene expression and subsequent increase in free fatty acid (FFA) release. These results provide an insight in to the role of HNE-induced oxidative stress in regulation of adipocyte differentiation and adipose dysfunction. Taken together, these data indicate a potential role for HNE promoting diverse effects toward adipocyte homeostasis and adipocyte differentiation, which may be important to the pathogenesis observed in obesity and metabolic syndrome.
C1 [Dasuri, Kalavathi; Ebenezer, Philip; Fernandez-Kim, Sun Ok; Zhang, Le; Gao, Zhanguo; Bruce-Keller, Annadora J.; Freeman, Linnea R.; Keller, Jeffrey N.] Louisiana State Univ Syst, Pennington Biomed Res Ctr, Baton Rouge, LA 70808 USA.
C3 Louisiana State University System; Louisiana State University;
   Pennington Biomedical Research Center
RP Keller, JN (corresponding author), Louisiana State Univ Syst, Pennington Biomed Res Ctr, 6400 Perkins Rd, Baton Rouge, LA 70808 USA.
EM Jeffrey.keller@pbrc.edu
RI Bruce-Keller, Annadora/N-1954-2017; Keller, Jeffrey/N-1975-2017; DASURI,
   KALAVATHI/E-7381-2012
OI keller, jeffrey/0000-0002-9892-7423
FU Hibernia National Bank/Edward G. Schleider Chair; NIA [AG029885,
   AG025771]
FX This work was generously supported by the Hibernia National Bank/Edward
   G. Schleider Chair and grants from the NIA (AG029885 and AG025771) to
   J.N.K.
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NR 52
TC 20
Z9 24
U1 0
U2 15
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 1071-5762
J9 FREE RADICAL RES
JI Free Radic. Res.
PD JAN
PY 2013
VL 47
IS 1
BP 8
EP 19
DI 10.3109/10715762.2012.733003
PG 12
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 048FT
UT WOS:000311896600002
PM 23025469
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Beaudeux, JL
   Nivet-antoine, V
   Giral, P
AF Beaudeux, Jean-Louis
   Nivet-antoine, Valerie
   Giral, Philippe
TI Resveratrol: a relevant pharmacological approach for the treatment of
   metabolic syndrome?
SO CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE
LA English
DT Article
DE insulin resistance; metabolic syndrome; obesity; resveratrol; SIRT1;
   sirtuins
ID ACTIVATED PROTEIN-KINASE; INDUCED DIABETIC-RATS; SMALL-MOLECULE
   ACTIVATORS; PANCREATIC BETA-CELLS; CALORIE RESTRICTION; SKELETAL-MUSCLE;
   GLUCOSE-UPTAKE; CARBOHYDRATE-METABOLISM; 3T3-L1 ADIPOCYTES; OXIDATIVE
   STRESS
AB Purpose of review
   The metabolic syndrome is associated with increased risk for development of both cardiovascular disease and type 2 diabetes in humans. Because experimental data and clinical experience have shown that metabolic syndrome and caloric restriction have, at least partly, opposite pathophysiological pathways, the activation of sirtuins may constitute a pharmacological approach to treat metabolic syndrome. Resveratrol is a polyphenol produced by plants that has multiple beneficial activities similar to those associated with caloric restriction.
   Recent findings
   Through its regulatory action of both AMP kinase and the sirtuin sirtuin-1, resveratrol is a natural sirtuin activator that certainly will be the head of a new pharmacological family of drugs targeted on sirtuin-1 activity exacerbation in order to treat/protect from obesity and diabetes, and thus metabolic syndrome.
   Summary
   This review discusses the therapeutic use of resveratrol and sirtuin activators in the context of insulin resistance and obesity, the two main features of metabolic syndrome.
C1 [Beaudeux, Jean-Louis; Nivet-antoine, Valerie] APHP, Fac Pharm Paris & Descartes, EA Stress Cellulaire Physiopathol Strategies Nutr, Ivry, France.
   [Beaudeux, Jean-Louis; Nivet-antoine, Valerie] Hop Charles Foix, Serv Biochim, Paris, France.
   [Giral, Philippe] Hop La Pitie Salpetriere, APHP, U939 INSERM Dyslipidemies Inflammat & Atherosclero, Paris, France.
   [Giral, Philippe] Hop La Pitie Salpetriere, APHP, Serv Endocrinol Metab, Paris, France.
C3 Assistance Publique Hopitaux Paris (APHP); Hopital Universitaire
   Charles-Foix - APHP; Hopital Universitaire Ambroise-Pare - APHP;
   Universite Paris Cite; Assistance Publique Hopitaux Paris (APHP);
   Hopital Universitaire Charles-Foix - APHP; Sorbonne Universite;
   Assistance Publique Hopitaux Paris (APHP); Universite Paris Cite;
   Hopital Universitaire Hotel-Dieu - APHP; Sorbonne Universite; Institut
   National de la Sante et de la Recherche Medicale (Inserm); Hopital
   Universitaire Pitie-Salpetriere - APHP; Hopital Universitaire
   Ambroise-Pare - APHP; Assistance Publique Hopitaux Paris (APHP); Hopital
   Universitaire Pitie-Salpetriere - APHP; Sorbonne Universite; Hopital
   Universitaire Ambroise-Pare - APHP; Universite Paris Cite; Hopital
   Universitaire Hotel-Dieu - APHP
RP Beaudeux, JL (corresponding author), Fac Pharm Paris & Descartes, EA Stress Cellulaire Physiopathol Strategies Nutr, 4 Ave Observ, F-75006 Paris, France.
EM jean-louis.beaudeux@parisdescartes.fr
RI Nivet-Antoine, Valerie/R-1981-2017
OI Nivet-Antoine, Valerie/0000-0003-2490-0428
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NR 75
TC 36
Z9 39
U1 0
U2 14
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1363-1950
EI 1473-6519
J9 CURR OPIN CLIN NUTR
JI Curr. Opin. Clin. Nutr. Metab. Care
PD NOV
PY 2010
VL 13
IS 6
BP 729
EP 736
DI 10.1097/MCO.0b013e32833ef291
PG 8
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 671HV
UT WOS:000283492600020
PM 20823772
DA 2025-06-11
ER

PT J
AU Wang, W
   Li, JY
   Cui, SY
   Li, JY
   Ye, XL
   Wang, Z
   Zhang, TT
   Jiang, X
   Kong, YL
   Chen, X
   Chen, YQ
   Zhu, SL
AF Wang, Wei
   Li, Jinyou
   Cui, Siyuan
   Li, Jiayu
   Ye, Xianlong
   Wang, Zhe
   Zhang, Tingting
   Jiang, Xuan
   Kong, Yulin
   Chen, Xin
   Chen, Yong Q.
   Zhu, Shenglong
TI Microglial Ffar4 deficiency promotes cognitive impairment in the context
   of metabolic syndrome
SO SCIENCE ADVANCES
LA English
DT Article
ID GLUCAGON-LIKE PEPTIDE-1; FATTY-ACIDS; INFLAMMATION; GPR120;
   SUPPLEMENTATION; OMEGA-3-FATTY-ACIDS; DISEASE; OBESITY; MOUSE; RISK
AB Metabolic syndrome (MetS) is closely associated with an increased risk of dementia and cognitive impairment, and a complex interaction of genetic and environmental dietary factors may be implicated. Free fatty acid receptor 4 (Ffar4) may bridge the genetic and dietary aspects of MetS development. However, the role of Ffar4 in MetS-related cognitive dysfunction is unclear. In this study, we found that Ffar4 expression is down-regulated in MetS mice and MetS patients with cognitive impairment. Conventional and microglial conditional knockout of Ffar4 exacerbated high-fat diet (HFD)-induced cognitive dysfunction and anxiety, whereas microglial Ffar4 overexpression improved HFD-induced cognitive dysfunction and anxiety. Mechanistically, we found that microglial Ffar4 regulated microglial activation through type I interferon signaling. Microglial depletion and NF-kappa B inhibition partially reversed cognitive dysfunction and anxiety in microglia-specific Ffar4 knockout MetS mice. Together, these findings uncover a previously unappreciated role of Ffar4 in negatively regulating the NF-kappa B-IFN-beta signaling and provide an attractive therapeutic target for delaying MetS-associated cognitive decline.
C1 [Wang, Wei; Li, Jiayu; Wang, Zhe; Zhang, Tingting; Jiang, Xuan; Kong, Yulin; Chen, Yong Q.; Zhu, Shenglong] Jiangnan Univ, Wuxi Sch Med, Wuxi 214000, Peoples R China.
   [Li, Jinyou] Jiangnan Univ, Affiliated Hosp, Wuxi 214122, Peoples R China.
   [Cui, Siyuan; Chen, Xin; Zhu, Shenglong] Jiangnan Univ, Med Ctr, Wuxi 214002, Peoples R China.
   [Ye, Xianlong] Ganjiang Chinese Med Innovat Ctr, Nanchang 330000, Peoples R China.
C3 Jiangnan University; Jiangnan University; Jiangnan University
RP Chen, YQ; Zhu, SL (corresponding author), Jiangnan Univ, Wuxi Sch Med, Wuxi 214000, Peoples R China.; Zhu, SL (corresponding author), Jiangnan Univ, Med Ctr, Wuxi 214002, Peoples R China.
EM yqchen@jiangnan.edu.cn; shenglongzhu@jiangnan.edu.cn
RI Li, jiayu/HSH-7140-2023; Zhu, Shenglong/AAJ-1030-2020; Ye,
   Xianlong/HTP-9257-2023; 张, 婷婷/HOC-4021-2023; cui, siyuan/GSE-4687-2022;
   Chen, Yong Q/AAI-9864-2021
OI Li, Jinyou/0009-0008-1326-8811; zhu, shenglong/0000-0003-0145-7339; Ye,
   Xianlong/0000-0002-6620-3957; Chen, Yong Q/0000-0003-4747-4708
FU National Natural Science Foundation of China [82000808, 82000685]; Wuxi
   Taihu Lake Talent Plan, Supports for Leading Talents in Medical and
   Health Profession
FX This work was supported by the National Natural Science Foundation of
   China (82000808 and 82000685) and the Wuxi Taihu Lake Talent Plan,
   Supports for Leading Talents in Medical and Health Profession.
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NR 64
TC 7
Z9 7
U1 10
U2 21
PU AMER ASSOC ADVANCEMENT SCIENCE
PI WASHINGTON
PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA
SN 2375-2548
J9 SCI ADV
JI Sci. Adv.
PD FEB 2
PY 2024
VL 10
IS 5
AR eadj7813
DI 10.1126/sciadv.adj7813
PG 16
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA LK8L5
UT WOS:001186784700012
PM 38306420
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Lee, SW
   Jo, HH
   Kim, MR
   Kwon, DJ
   You, YO
   Kim, JH
AF Lee, Suk Woo
   Jo, Hyun Hee
   Kim, Mee Ran
   Kwon, Dong Jin
   You, Young Oak
   Kim, Jang Heup
TI Association between menopausal symptoms and metabolic syndrome in
   postmenopausal women
SO ARCHIVES OF GYNECOLOGY AND OBSTETRICS
LA English
DT Article
DE Menopausal symptoms; Menopause; Metabolic syndrome
ID RISK-FACTORS; CARDIOVASCULAR-DISEASE; HORMONE-THERAPY; HOT FLASHES;
   DEPRESSION; ADIPOSITY; ANXIETY; OBESITY
AB Menopausal symptoms are major concerns of postmenopausal women. Metabolic syndrome (MetS) is a risk factor for cardiovascular disease, and menopause is associated with an increased prevalence of MetS. The purpose of this study was to determine the association between menopausal symptoms and MetS in postmenopausal women.
   We selected 183 women who attended St. Vincent Hospital of the Catholic University of Korea in 2008 and 2009 and divided them into two groups (with and without MetS). Menopausal status was assessed with the Menopause Rating Scale (MRS) questionnaire. The body mass index and waist-to-hip ratio were determined, and the serum fasting glucose, lipid profile, and blood pressure were measured in all participants.
   Of 183 postmenopausal women, 64 (35.0%) had MetS. A significant increase was observed in the total MRS score and the total somatic symptom subscale score in the MetS group (p = 0.021, p = 0.043, respectively). Vasomotor symptoms such as hot flashes and sweating occurred with higher frequency in the MetS group than in those without MetS (p = 0.034). High triglyceride levels and an increase of the number of components of MetS were associated with a higher total subscale score of somatic symptoms (p = 0.044, p = 0.039, respectively).
   These results showed that a higher total subscale score and a higher frequency of somatic symptoms such as hot flashes and sweating were present in the MetS group. Larger scale studies are needed to clarify the association between other menopausal symptoms and MetS in postmenopausal women.
C1 [Lee, Suk Woo; Kwon, Dong Jin; You, Young Oak] Catholic Univ Korea, St Vincents Hosp, Coll Med, Dept Obstet & Gynecol, Suwon, Gyeonggi Do, South Korea.
   [Jo, Hyun Hee; Kim, Mee Ran; Kim, Jang Heup] Catholic Univ Korea, Seoul St Marys Hosp, Coll Med, Dept Obstet & Gynecol, Suwon, Gyeonggi Do, South Korea.
C3 Catholic University of Korea; Seoul St. Mary's Hospital; Catholic
   University of Korea
RP You, YO (corresponding author), Catholic Univ Korea, St Vincents Hosp, Coll Med, Dept Obstet & Gynecol, 93-6 Ji Dong, Suwon, Gyeonggi Do, South Korea.
EM yolew@catholic.ac.kr
RI Lee, Suk/U-9987-2019; Kim, Woo/AAG-1822-2019
OI Kim, Mee-Ran/0000-0003-4492-0768
CR Alberti KGMM, 1998, DIABETIC MED, V15, P539, DOI 10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S
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NR 33
TC 40
Z9 41
U1 0
U2 10
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0932-0067
EI 1432-0711
J9 ARCH GYNECOL OBSTET
JI Arch. Gynecol. Obstet.
PD FEB
PY 2012
VL 285
IS 2
BP 541
EP 548
DI 10.1007/s00404-011-2016-5
PG 8
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA 876PV
UT WOS:000299120800041
PM 21853251
DA 2025-06-11
ER

PT J
AU Yao, H
   Mizoguchi, Y
   Monji, A
   Yakushiji, Y
   Takashima, Y
   Uchino, A
   Yuzuriha, T
   Hashimoto, M
AF Yao, Hiroshi
   Mizoguchi, Yoshito
   Monji, Akira
   Yakushiji, Yusuke
   Takashima, Yuki
   Uchino, Akira
   Yuzuriha, Takefumi
   Hashimoto, Manabu
TI Low-Grade Inflammation Is Associated with Apathy Indirectly via Deep
   White Matter Lesions in Community-Dwelling Older Adults: The Sefuri
   Study
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE physical activity; apathy; vascular depression; vascular cognitive
   impairment; white matter lesions; magnetic resonance imaging; small
   vessel disease; silent stroke
ID C-REACTIVE PROTEIN; SMALL-VESSEL DISEASE; METABOLIC SYNDROME; DEPRESSIVE
   SYMPTOMS; ISCHEMIC-STROKE; COGNITIVE IMPAIRMENT; ATHEROSCLEROSIS RISK;
   VASCULAR DEPRESSION; ELDERLY SUBJECTS; BLOOD-FLOW
AB Low-grade inflammation is implicated in the pathogenesis of atherosclerosis, metabolic syndrome, and apathy as a form of vascular depression. We analyzed the brain magnetic resonance imaging findings in 259 community-dwelling older adults (122 men and 137 women, with a mean age of 68.4 years). The serum concentrations of high-sensitivity C-reactive protein (hsCRP) were measured by a quantitative enzyme-linked immunosorbent assay. Logistic regression analysis revealed that the log(10) hsCRP value and the presence of a metabolic syndrome were independently associated with confluent but not punctate deep white matter lesions (DWMLs). Path analysis based on structural equation modeling (SEM) indicated that the direct path from the log(10) hsCRP to the DWMLs was significant ( = 0.119, p = 0.039). The direct paths from the metabolic syndrome to the log(10) hsCRP and to the DWMLs were also significant. The direct path from the DWMLs to apathy ( = -0.165, p = 0.007) was significant, but the direct path from the log(10) hsCRP to apathy was not significant. Inflammation (i.e., elevated serum hsCRP levels) was associated with DWMLs independent of common vascular risk factors, while DWMLs were associated with apathy. The present analysis with SEM revealed the more realistic scheme that low-grade inflammation was associated with apathy indirectly via DWMLs in community-dwelling older adults.
C1 [Yao, Hiroshi; Takashima, Yuki; Yuzuriha, Takefumi; Hashimoto, Manabu] Natl Hosp Org Hizen Psychiat Ctr, Div Clin Res, Saga 8420192, Japan.
   [Mizoguchi, Yoshito; Monji, Akira] Saga Univ, Dept Psychiat, Fac Med, Saga 8498501, Japan.
   [Yakushiji, Yusuke] Saga Univ, Div Neurol, Dept Internal Med, Fac Med, Saga 8498501, Japan.
   [Uchino, Akira] Saitama Med Univ Int Med Ctr, Dept Diagnost Radiol, Saitama 3501298, Japan.
C3 Saga University; Saga University; Saitama Medical University
RP Yao, H (corresponding author), Natl Hosp Org Hizen Psychiat Ctr, Div Clin Res, Saga 8420192, Japan.
EM rinkenyao@abelia.ocn.ne.jp; ymizo@cc.saga-u.ac.jp; amonji@hf.rim.or.jp;
   yakushij@cc.saga-u.ac.jp; ytakahizen@yahoo.co.jp;
   auchino@saitama-med.ac.jp; takefumi@hosp.go.jp; ma9hashi@yahoo.co.jp
RI Yao, Hiroshi/K-1374-2019
OI Yakushiji, Yusuke/0000-0003-3206-6939
FU JSPS KAKENHI [17K10322]; Grants-in-Aid for Scientific Research
   [17K10322] Funding Source: KAKEN
FX This work was supported by JSPS KAKENHI Grant Number 17K10322.
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   Yao H, 2015, J STROKE CEREBROVASC, V24, P2625, DOI 10.1016/j.jstrokecerebrovasdis.2015.07.018
   Yao H, 2009, HYPERTENS RES, V32, P586, DOI 10.1038/hr.2009.65
NR 57
TC 16
Z9 16
U1 0
U2 3
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD APR 2
PY 2019
VL 20
IS 8
AR 1905
DI 10.3390/ijms20081905
PG 12
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA HX8ID
UT WOS:000467648700103
PM 30999680
OA gold, Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Li, C
   Birmaher, B
   Rooks, B
   Gill, MK
   Hower, H
   Axelson, DA
   Dickstein, DP
   Goldstein, TR
   Liao, FZ
   Yen, S
   Hunt, J
   Iyengar, S
   Ryan, ND
   Strober, MA
   Keller, MB
   Goldstein, BI
AF Li, Christine
   Birmaher, Boris
   Rooks, Brian
   Gill, Mary Kay
   Hower, Heather
   Axelson, David A.
   Dickstein, Daniel P.
   Goldstein, Tina R.
   Liao, Fangzi
   Yen, Shirley
   Hunt, Jeffrey
   Iyengar, Satish
   Ryan, Neal D.
   Strober, Michael A.
   Keller, Martin B.
   Goldstein, Benjamin, I
TI High Prevalence of Metabolic Syndrome Among Adolescents and Young Adults
   With Bipolar Disorder
SO JOURNAL OF CLINICAL PSYCHIATRY
LA English
DT Article
ID MAJOR DEPRESSIVE DISORDER; SCHOOL-AGE-CHILDREN; COMORBID MEDICAL
   CONDITIONS; PSYCHIATRIC OUTCOMES; ITALIAN PATIENTS; MENTAL-HEALTH;
   OBESITY; SCHIZOPHRENIA; ANTIPSYCHOTICS; COMMUNITY
AB Objective: Despite abundant literature demonstrating increased metabolic syndrome (MetS) prevalence and important clinical correlates of MetS among middle-age adults with bipolar disorder, little is known about this topic among adolescents and young adults early in their course of bipolar disorder. We therefore examined this topic in the Course and Outcome of Bipolar Youth (COBY) study.
   Methods: A cross-sectional, retrospective study was conducted of 162 adolescents and young adults (mean +/- SD age =20.8 +/- 3.7 years; range, 13.6-28.3 years) with bipolar disorder (I, II, or not otherwise specified, based on DSM-IV) enrolled in COBY between 2000 and 2006. MetS measures (blood pressure, glucose, high-density lipoprotein cholesterol [HDL-C], triglycerides, and waist circumference), defined using the International Diabetes Federation criteria, were obtained at a single timepoint. Mood, comorbidity, and treatment over the 6 months preceding the MetS assessment were evaluated using the Longitudinal Interval Follow-Up Evaluation.
   Results: The prevalence of MetS in the sample was 19.8% (32/162). Low HDL-C (56.5%) and abdominal obesity (46.9%) were the most common MetS criteria. MetS was nominally associated with lower lifetime global functioning at COBY intake (odds ratio [OR] =0.97, P= .06). MetS was significantly associated with percentage of weeks in full-threshold pure depression (OR =1.07, P = .02) and percentage of weeks receiving antidepressant medications (OR= 1.06, P =.001) in the preceding 6 months. MetS was not associated with manic symptoms or medications other than antidepressants.
   Conclusions: The prevalence of MetS in this sample was at least double compared to the general population. Moreover, MetS is associated with increased burden of depression symptoms in this group. Management of early-onset bipolar disorder should integrate strategies focused on modifying MetS risk factors.
C1 [Li, Christine; Goldstein, Benjamin, I] Sunnybrook Hlth Sci Ctr, Ctr Youth Bipolar Disorder, 2075 Bay View Ave,EG-48, Toronto, ON, Canada.
   [Li, Christine; Goldstein, Benjamin, I] Univ Toronto, Fac Med, Toronto, ON, Canada.
   [Birmaher, Boris; Rooks, Brian; Gill, Mary Kay; Goldstein, Tina R.; Liao, Fangzi; Ryan, Neal D.] Univ Pittsburgh, Sch Med, Dept Psychiat, Western Psychiat Inst & Clin, Pittsburgh, PA USA.
   [Hower, Heather; Dickstein, Daniel P.; Yen, Shirley; Hunt, Jeffrey] Brown Univ, Warren Alpert Med Sch, Dept Psychiat & Human Behav, Providence, RI 02912 USA.
   [Axelson, David A.] Nationwide Childrens Hosp, Dept Psychiat, Columbus, OH USA.
   [Axelson, David A.] Ohio State Coll Med, Columbus, OH USA.
   [Dickstein, Daniel P.; Hunt, Jeffrey] Bradley Hosp, Riverside, RI USA.
   [Yen, Shirley; Keller, Martin B.] Butler Hosp, Riverside, RI USA.
   [Iyengar, Satish] Univ Pittsburgh, Dept Stat, Pittsburgh, PA USA.
   [Strober, Michael A.] Univ Calif Los Angeles, David Geffen Sch Med, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90095 USA.
   [Yen, Shirley] Beth Israel Deaconess Med Ctr, Massachusetts Mental Hlth Ctr, Boston, MA 02215 USA.
   [Yen, Shirley] Beth Israel Deaconess Med Ctr, Dept Psychiat, Boston, MA 02215 USA.
C3 University of Toronto; Sunnybrook Research Institute; Sunnybrook Health
   Science Center; University of Toronto; Pennsylvania Commonwealth System
   of Higher Education (PCSHE); University of Pittsburgh; Western
   Psychiatric Institute & Clinic of UPMC; Brown University; University
   System of Ohio; Ohio State University; Nationwide Childrens Hospital;
   University System of Ohio; Ohio State University; Pennsylvania
   Commonwealth System of Higher Education (PCSHE); University of
   Pittsburgh; University of California System; University of California
   Los Angeles; University of California Los Angeles Medical Center; David
   Geffen School of Medicine at UCLA; Harvard University; Harvard
   University Medical Affiliates; Beth Israel Deaconess Medical Center;
   Harvard University; Harvard University Medical Affiliates; Beth Israel
   Deaconess Medical Center
RP Goldstein, BI (corresponding author), Sunnybrook Hlth Sci Ctr, Ctr Youth Bipolar Disorder, 2075 Bay View Ave,EG-48, Toronto, ON, Canada.
EM benjamin.goldstein@sunnybrook.ca
RI Goldstein, Benjamin/ADR-2374-2022; Dickstein, Daniel/L-3210-2016
OI Goldstein, Tina/0000-0002-4762-8060; Hower, Heather/0000-0002-9411-2059;
   Dickstein, Daniel/0000-0003-1647-5329
FU National Institute of Mental Health (NIMH) Course and Outcome of Bipolar
   Youth (COBY) study grants [MH059929, MH59691, MH59977]
FX This research was supported by the National Institute of Mental Health
   (NIMH) Course and Outcome of Bipolar Youth (COBY) study grants MH059929
   (Dr Birmaher), MH59691 (Dr Keller/Dr Yen), and MH59977 (Dr Strober).
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NR 65
TC 40
Z9 42
U1 0
U2 11
PU PHYSICIANS POSTGRADUATE PRESS
PI MEMPHIS
PA P O BOX 752870, MEMPHIS, TN 38175-2870 USA
SN 0160-6689
EI 1555-2101
J9 J CLIN PSYCHIAT
JI J. Clin. Psychiatry
PD JUL-AUG
PY 2019
VL 80
IS 4
AR 18m12422
DI 10.4088/JCP.18m12422
PG 9
WC Psychology, Clinical; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA JC8VO
UT WOS:000489554400003
PM 31365195
OA Green Accepted, Green Submitted
DA 2025-06-11
ER

PT J
AU Jang, J
   Futeran, S
   Large, M
   Curtis, J
AF Jang, Jae
   Futeran, Shuli
   Large, Matthew
   Curtis, Jackie
TI An audit of general practitioner involvement in public community mental
   health care
SO AUSTRALASIAN PSYCHIATRY
LA English
DT Article
DE physical health; general practitioner; metabolic syndrome; community
   psychiatry
ID PSYCHOTIC DISORDERS; LIFE EXPECTANCY; RISK-FACTORS; LOW RATES; ILLNESS;
   MORTALITY; SCHIZOPHRENIA; PEOPLE; TRIAL
AB Objective: Existing guidelines suggest that collaboration between general practitioners and mental health services may improve the physical health of people with serious mental illness. This study investigated the extent of general practitioner involvement in a community mental health centre and examined whether the presence of a documented general practitioner in the patient's medical records was associated with markers of better health outcomes.
   Methods: The medical records of current patients were audited, including those receiving medical care and case management and those only receiving medical care. The demographic and diagnostic information, evidence of metabolic screening, blood test results, and medications of patients with a recorded general practitioner were compared with those of patients with no recorded general practitioner.
   Results: Ninety-eight of 191 (51%) of patients had details of a general practitioner documented in their medical records. There were no significant differences in rates of metabolic screening between the two groups. Those with a general practitioner had more medical diagnoses and were taking a greater number of psychiatric medications.
   Conclusion: Although the medical comorbidities of serious mental illness are becoming increasingly recognised, our findings suggest the need for ongoing and coordinated efforts by policymakers, general practitioners, mental health services and patients to ensure the health and longevity of people with serious mental illness.
C1 [Jang, Jae; Futeran, Shuli; Large, Matthew; Curtis, Jackie] Univ New S Wales, Sch Psychiat, Fac Med, Sydney, NSW, Australia.
   [Futeran, Shuli; Large, Matthew; Curtis, Jackie] South Eastern Sydney Local Hlth Dist, Eastern Suburbs Mental Hlth Serv, Sydney, NSW, Australia.
C3 University of New South Wales Sydney; South Eastern Sydney Local Health
   District
RP Futeran, S (corresponding author), Maroubra Community Mental Hlth, Maroubra, NSW 2035, Australia.
EM Shuli.Futeran@sesiahs.health.nsw.gov.au
RI Large, Matthew/I-5322-2013; Curtis, Jackie/J-5789-2019
OI Curtis, Jackie/0000-0001-6884-0098
CR Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
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NR 25
TC 5
Z9 5
U1 0
U2 14
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1039-8562
EI 1440-1665
J9 AUSTRALAS PSYCHIATRY
JI Australas. Psychiatry
PD OCT
PY 2015
VL 23
IS 5
BP 571
EP 574
DI 10.1177/1039856215592479
PG 4
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA CS2NA
UT WOS:000361906700024
PM 26139704
DA 2025-06-11
ER

PT J
AU Kábelová, A
   Malínská, H
   Marková, I
   Oliyarnyk, O
   Chylíková, B
   Seda, O
AF Kabelova, Adela
   Malinska, Hana
   Markova, Irena
   Oliyarnyk, Olena
   Chylikova, Blanka
   Seda, Ondrej
TI Ellagic Acid Affects Metabolic and Transcriptomic Profiles and
   Attenuates Features of Metabolic Syndrome in Adult Male Rats
SO NUTRIENTS
LA English
DT Article
DE metabolic syndrome; ellagic acid; brown adipose tissue; insulin
   resistance; oxidative stress
AB Ellagic acid, a natural substance found in various fruits and nuts, was previously shown to exhibit beneficial effects towards metabolic syndrome. In this study, using a genetic rat model of metabolic syndrome, we aimed to further specify metabolic and transcriptomic responses to ellagic acid treatment. Adult male rats of the SHR-Zbtb16(Lx)(/k.o.) strain were fed a high-fat diet accompanied by daily intragastric gavage of ellagic acid (50 mg/kg body weight; high-fat diet-ellagic acid (HFD-EA) rats) or vehicle only (high-fat diet-control (HFD-CTL) rats). Morphometric and metabolic parameters, along with transcriptomic profile of liver and brown and epididymal adipose tissues, were assessed. HFD-EA rats showed higher relative weight of brown adipose tissue (BAT) and decreased weight of epididymal adipose tissue, although no change in total body weight was observed. Glucose area under the curve, serum insulin, and cholesterol levels, as well as the level of oxidative stress, were significantly lower in HFD-EA rats. The most differentially expressed transcripts reflecting the shift induced by ellagic acid were detected in BAT, showing downregulation of BAT activation markers Dio2 and Nr4a1 and upregulation of insulin-sensitizing gene Pla2g2a. Ellagic acid may provide a useful nutritional supplement to ameliorate features of metabolic syndrome, possibly by suppressing oxidative stress and its effects on brown adipose tissue.
C1 [Kabelova, Adela; Chylikova, Blanka; Seda, Ondrej] Charles Univ Prague, Fac Med 1, Inst Biol & Med Genet, Prague 12108, Czech Republic.
   [Kabelova, Adela; Chylikova, Blanka; Seda, Ondrej] Gen Univ Hosp, Prague 12108, Czech Republic.
   [Malinska, Hana; Markova, Irena; Oliyarnyk, Olena] Inst Clin & Expt Med, Prague 14021, Czech Republic.
C3 Charles University Prague; General University Hospital Prague; Institute
   for Clinical & Experimental Medicine (IKEM)
RP Seda, O (corresponding author), Charles Univ Prague, Fac Med 1, Inst Biol & Med Genet, Prague 12108, Czech Republic.; Seda, O (corresponding author), Gen Univ Hosp, Prague 12108, Czech Republic.
EM adela.kabelova@lf1.cuni.cz; haml@ikem.cz; irma@ikem.cz;
   ooliyarnyk@yahoo.com; blanka.chylikova@lf1.cuni.cz; oseda@lf1.cuni.cz
RI Oliyarnyk, Olena/Q-6380-2019; Chylikova, Blanka/D-2976-2017; Seda,
   Ondrej/A-2058-2008
OI Seda, Ondrej/0000-0001-8498-5895; Malinska, Hana/0000-0002-9076-3399;
   Markova, Irena/0000-0002-4331-7636
FU Charles University in Prague [GAUK 1132218, PROGRES-Q25/LF1, SVV
   260516]; Ministry of Health, Czech Republic-conceptual development of
   research organization, General University Hospital in Prague, Czechia
   [64165]
FX This research was funded by Charles University in Prague (GAUK 1132218,
   PROGRES-Q25/LF1, SVV 260516) and Ministry of Health, Czech
   Republic-conceptual development of research organization 64165, General
   University Hospital in Prague, Czechia.
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NR 58
TC 12
Z9 12
U1 2
U2 34
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD MAR
PY 2021
VL 13
IS 3
AR 804
DI 10.3390/nu13030804
PG 13
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA RE2GA
UT WOS:000633978300001
PM 33671116
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Mugisha, J
   De Hert, M
   Stubbs, B
   Basangwa, D
   Vancampfort, D
AF Mugisha, James
   De Hert, Marc
   Stubbs, Brendon
   Basangwa, David
   Vancampfort, Davy
TI Physical health policies and metabolic screening in mental health care
   systems of sub-Saharan African countries: a systematic review
SO INTERNATIONAL JOURNAL OF MENTAL HEALTH SYSTEMS
LA English
DT Review
DE Physical health; Somatic; Metabolic; Mental health; Sub-Sahara Africa
ID MAJOR DEPRESSIVE DISORDER; BIPOLAR DISORDER; SCHIZOPHRENIA; RISK;
   ILLNESS; PEOPLE; ANTIPSYCHOTICS; METAANALYSIS; PREVALENCE; GUIDELINES
AB Background: There is a need for interventions to address the escalating mental health burden in sub-Saharan Africa (SSA). Addressing physical health needs should have a central role in reducing the burden and facilitating recovery in people with severe mental illness (SMI). We systematically investigated (1) physical health policies in the current mental health plans, and (2) the routine metabolic screening rates for people with SMI in SSA.
   Methods: The Mental Health Atlas and MiNDbank of the World Health Organization were screened for physical health policies in mental health plans. Next, we systematically searched PubMed from inception until February 1st, 2017 for relevant studies on metabolic screening rates in people with SMI in SSA.
   Results: The current systematic review shows that in 22 screened plans only 6 made reference to a physical health component or policy. Only the South-African mental health plan reported about routine screening and treatment of physical illness for people with SMI. In 2 South-African studies (n = 431) routine screening was unacceptably low with less than 1% adequately screened for all modifiable metabolic syndrome risk factors.
   Conclusions: Our review data clearly show that a physical health policy is yet to be embraced in mental health care systems of most SSA countries. There is a clear need for integrated mental and medical services in SSA. All psychiatric services, including poorly developed community-based primary health care settings should standardly assess the body mass index and waist circumference at initiation of psycho-pharmacotherapy, and afterwards at regular intervals. Optimal monitoring should include assessments of fasting glucose, lipids, cholesterol, and blood pressure. Mental health care providers in SSA countries need to be informed that their roles extend beyond taking care of the mental health of their patients and assume responsibility for the physical health of their patients as well. Policy makers should be made aware that investment in continued medial education and in screening for physical health risks could optimize mental and physical health improvements. The increased physical health needs of people with mental illness should be integrated into the existing Information, Education and Communication public health awareness programs of the World Health Organization.
C1 [Mugisha, James; Basangwa, David] Butabika Natl Referral & Mental Hlth Hosp, Kampala, Uganda.
   [Mugisha, James] Kyambogo Univ, Kampala, Uganda.
   [De Hert, Marc; Vancampfort, Davy] Katholieke Univ Leuven, Univ Leuven, Univ Psychiat Ctr, Louvain, Belgium.
   [Stubbs, Brendon] South London & Maudsley NHS Fdn Trust, Physiotherapy Dept, London, England.
   [Stubbs, Brendon] Kings Coll London, Inst Psychiat Psychol & Neurosci, Hlth Serv & Populat Res Dept, De Crespigny Pk, London, England.
   [Vancampfort, Davy] Univ Leuven, KU Leuven, Dept Rehabil Sci, Louvain, Belgium.
C3 Kyambogo University; KU Leuven; South London & Maudsley NHS Trust;
   University of London; King's College London; KU Leuven
RP Mugisha, J (corresponding author), Kyambogo Univ, Kampala, Uganda.
EM jmmugi77@hotmail.com
RI De Hert, Marc/AAH-6090-2021; Vancampfort, Davy/AAD-1987-2019; Stubbs,
   Brendon/X-1904-2018; Stubbs, Brendon/C-5696-2015
OI Mugisha, James/0000-0003-2084-8693; Stubbs, Brendon/0000-0001-7387-3791;
   De Hert, Marc/0000-0003-4255-5920
CR [Anonymous], EV GLOB BURD DIS GEN
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NR 29
TC 10
Z9 13
U1 0
U2 4
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1752-4458
J9 INT J MENT HEALTH SY
JI Int. J. Ment. Health Syst.
PD APR 19
PY 2017
VL 11
AR 31
DI 10.1186/s13033-017-0141-7
PG 7
WC Psychiatry
WE Social Science Citation Index (SSCI)
SC Psychiatry
GA EU8KC
UT WOS:000401286800002
PM 28428816
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Bossé, S
   Stalder, T
   D'Antono, B
AF Bosse, Stephanie
   Stalder, Tobias
   D'Antono, Bianca
TI Childhood Trauma, Perceived Stress, and Hair Cortisol in Adults With and
   Without Cardiovascular Disease
SO PSYCHOSOMATIC MEDICINE
LA English
DT Article
DE aging; childhood trauma; coronary artery disease; hair cortisol;
   perceived stress; sex differences
ID CORONARY-HEART-DISEASE; HPA-AXIS REACTIVITY; PSYCHOLOGICAL STRESS;
   PSYCHOSOCIAL STRESS; UNITED-STATES; METABOLIC SYNDROME; SALIVARY
   CORTISOL; FUTURE-DIRECTIONS; SEX-DIFFERENCES; PHYSICAL ABUSE
AB Objective Childhood trauma has been associated with greater psychological and physical morbidity, including a greater risk of developing cardiovascular disease (CVD). This may partially reflect trauma-induced disturbances in how stress is later perceived and regulated. This study evaluated the associations of childhood trauma with perceived stress and hair cortisol concentrations (HCC) in a large sample of adults with coronary artery disease (CAD) and in non-CVD patients experiencing other nonfatal illnesses. Whether sex, age, or CVD status influenced these associations was also examined.
   Methods A total of 1124 men and women (aged 65.2 [6.9] years) recruited from a hospital cohort completed the Childhood Trauma and Perceived Stress Questionnaires, whereas hair samples were obtained from 598 participants. Health status was confirmed via medical records.
   Results Moderate to severe childhood trauma was experienced by 359 participants. Childhood trauma was associated with greater perceived stress levels for the past 2 years (r = .308, p = .01; = 0.263, p < .001), but not 3-month cortisol secretion in hair. Perceived stress correlated negatively with age (r = -.241, p < .001). In secondary analyses, age moderated the relation between sexual abuse and perceived stress ( = -0.067, p = .016). Although sexual abuse was associated with greater levels of perceived stress among all participants, this relation was strongest in younger individuals.
   Conclusions Participants who experienced trauma in their youth reported greater levels of perceived stress, but not HCC, in late adulthood. Whether this suggests intact hypothalamic-pituitary-adrenal regulation in those exposed to childhood trauma or whether this reflects the characteristics of our sample requires further investigation.
C1 [Bosse, Stephanie; D'Antono, Bianca] Montreal Heart Inst, Res Ctr, 5000 Belanger St, Montreal, PQ H1T 1C8, Canada.
   [Bosse, Stephanie; D'Antono, Bianca] Univ Montreal, Psychol Dept, Montreal, PQ, Canada.
   [Stalder, Tobias] Tech Univ Dresden, Inst Psychol, Dresden, Germany.
   [Stalder, Tobias] Univ Siegen, Clin Psychol, Siegen, Germany.
C3 Universite de Montreal; Universite de Montreal; Technische Universitat
   Dresden; Universitat Siegen
RP D'Antono, B (corresponding author), Montreal Heart Inst, Res Ctr, 5000 Belanger St, Montreal, PQ H1T 1C8, Canada.
EM bianca.d.antono@umontreal.ca
OI Stalder, Tobias/0000-0001-7558-1274
FU Canadian Institutes of Health Research (CIHR) [111015]
FX This research was supported by grants awarded to BDA by the Canadian
   Institutes of Health Research (CIHR; MOP # 111015). The authors report
   no conflicts of interest.
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NR 88
TC 27
Z9 31
U1 1
U2 33
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0033-3174
EI 1534-7796
J9 PSYCHOSOM MED
JI Psychosom. Med.
PD MAY
PY 2018
VL 80
IS 4
BP 393
EP 402
DI 10.1097/PSY.0000000000000569
PG 10
WC Psychiatry; Psychology; Psychology, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry; Psychology
GA GE4JD
UT WOS:000431180800008
PM 29521884
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Wynaden, D
   Heslop, B
   Heslop, K
   Barr, L
   Lim, E
   Chee, GL
   Porter, J
   Murdock, J
AF Wynaden, Dianne
   Heslop, Brett
   Heslop, Karen
   Barr, Lesley
   Lim, Eric
   Chee, Gin-Liang
   Porter, James
   Murdock, Jane
TI The chasm of care: Where does the mental health nursing responsibility
   lie for the physical health care of people with severe mental illness?
SO INTERNATIONAL JOURNAL OF MENTAL HEALTH NURSING
LA English
DT Article
DE leadership; mental health nursing; physical health care; severe mental
   illness
ID SERVICE USERS; TOBACCO DEPENDENCE; METABOLIC SYNDROME;
   SMOKING-CESSATION; NURSES ATTITUDES; SELF-MANAGEMENT; RISK-FACTORS;
   ACCESS; ADULTS; INTERVENTIONS
AB The poor physical health of people with a severe mental illness is well documented and health professionals' attitudes, knowledge and skills are identified factors that impact on clients' access to care for their physical health needs. An evaluation was conducted to determine: (i) mental health nurses' attitudes and beliefs about providing physical health care; and, (ii) the effect that participant demographics may have on attitudes to providing physical health care. It was hypothesized that workplace culture would have the largest effect on attitudes. Nurses at three health services completed the "Mental health nurses' attitude towards the physical health care of people with severe and enduring mental illness survey" developed by Robson and Haddad (2012). The 28-item survey measured: nurses' attitudes, confidence, identified barriers to providing care and attitudes towards clients smoking cigarettes. The findings demonstrated that workplace culture did influence the level of physical health care provided to clients. However, at the individual level, nurses remain divided and uncertain where their responsibilities lie. Nursing leadership can have a significant impact on improving clients' physical health outcomes. Education is required to raise awareness of the need to reduce cigarette smoking in this client population.
C1 [Wynaden, Dianne; Heslop, Karen; Lim, Eric; Chee, Gin-Liang] Curtin Univ, Sch Nursing Midwifery & Paramed, GPO Box U 1987, Perth, WA 6845, Australia.
   [Heslop, Brett; Porter, James] Rockingham Peel Mental Hlth Serv, Rockingham, Australia.
   [Barr, Lesley] State Forens Mental Hlth Serv, Brockway, Australia.
   [Murdock, Jane] Fremantle Mental Hlth Serv, Fremantle, WA, Australia.
C3 Curtin University
RP Wynaden, D (corresponding author), Curtin Univ, Sch Nursing Midwifery & Paramed, GPO Box U 1987, Perth, WA 6845, Australia.
EM d.wynaden@curtin.edu.au
RI Heslop, Karen/AFM-4040-2022; Lim, Eric/S-1371-2019; Barr,
   Lesley/M-4796-2018
OI Barr, Lesley/0000-0002-6617-6960; Wynaden, Dianne/0000-0002-3985-7621;
   Heslop, Karen/0000-0002-1136-3718; Lim, Eric/0000-0003-4860-9336
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NR 93
TC 35
Z9 37
U1 1
U2 15
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1445-8330
EI 1447-0349
J9 INT J MENT HEALTH NU
JI Int. J. Ment. Health Nurs.
PD DEC
PY 2016
VL 25
IS 6
BP 516
EP 525
DI 10.1111/inm.12242
PG 10
WC Nursing; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Psychiatry
GA EJ6MV
UT WOS:000393334400005
PM 27416949
DA 2025-06-11
ER

PT J
AU Kanauchi, M
   Kubo, A
   Kanauchi, K
   Saito, Y
AF Kanauchi, M.
   Kubo, A.
   Kanauchi, K.
   Saito, Y.
TI Frailty, health-related quality of life and mental well-being in older
   adults with cardiometabolic risk factors
SO INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
LA English
DT Article
ID DIABETES-MELLITUS; TREATMENT SATISFACTION; DEPRESSION; PREVALENCE;
   PEOPLE; TOOL
AB Objective: Frailty is an emergent health-related problem in older adults. The aim of this study was to examine the health-related quality of life (HRQOL) and the effect of frailty in elderly patients with cardiometabolic risk factors. Methods: One-hundred and one patients 65 years or older responded to an HRQOL assessment using the World Health Organization Quality of Life (WHOQOL)-26 questionnaire. Frailty was assessed using two indices: the Hebrew Rehabilitation Center for Aged (HRCA) vulnerability index and the Vulnerable Elders Survey (VES) index. In addition, these patients completed self-rating questionnaires assessing mental well-being [the 28-item version of the General Health Questionnaire (GHQ-28)] and depression (Geriatric Depression Scale). Results: Based on the combination of HRCA and VES indices, 24 subjects (23.7%) met the criteria of frail. Persons >= 75 years old and those with depressive mood or lower creatinine clearance had significantly lower WHOQOL-26 scores than their counterparts. Diabetes and macrovascular complications did not associate with the WHOQOL-26 scores. Compared with non-frail patients, the frail scored lower on the WHOQOL-26 questionnaire after adjusting for age, kidney dysfunction and depressive mood. Frail patients also reported significantly higher the GHQ-28 scores compared with non-frail patients. Conclusions: Frail older adults had a significant lower HRQOL, as well as lower mental well-being, independent of age, diabetes, macrovascular complication, kidney dysfunction and depressed mood.
C1 [Kanauchi, M.; Kubo, A.; Kanauchi, K.; Saito, Y.] Nara Med Univ, Dept Internal Med 1, Nara 6340813, Japan.
C3 Nara Medical University
RP Kanauchi, M (corresponding author), Nara Med Univ, Dept Internal Med 1, 840 Shijo Cho, Nara 6340813, Japan.
EM kanauchi@nmu-gw.naramed-u.ac.jp
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NR 23
TC 47
Z9 52
U1 1
U2 20
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1368-5031
EI 1742-1241
J9 INT J CLIN PRACT
JI Int. J. Clin. Pract.
PD SEP
PY 2008
VL 62
IS 9
BP 1447
EP 1451
DI 10.1111/j.1742-1241.2008.01830.x
PG 5
WC Medicine, General & Internal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine; Pharmacology & Pharmacy
GA 335LC
UT WOS:000258291100024
PM 18643932
OA gold
DA 2025-06-11
ER

PT J
AU Tinahones, FJ
   Garrido-Sánchez, L
   Murri, M
   García-Fuentes, E
   Cardona, F
AF Tinahones, Francisco J.
   Garrido-Sanchez, Lourdes
   Murri, Mora
   Garcia-Fuentes, Eduardo
   Cardona, Fernando
TI Particular characteristics of the metabolic syndrome in patients with
   morbid obesity
SO ENDOCRINOLOGIA Y NUTRICION
LA English
DT Article
DE Metabolic syndrome; Postprandial hypertriglyceridemia; Free fatty acids;
   Morbid obesity
ID ADIPOSE-TISSUE EXPANDABILITY; MEDIATED GLUCOSE DISPOSAL;
   FREE-FATTY-ACIDS; INSULIN-RESISTANCE; OXIDATIVE STRESS; RISK-FACTOR;
   HYPERINSULINEMIA; EXPRESSION; PREDICTOR; WAIST
AB Background: Criteria for the diagnosis of the metabolic syndrome are currently being reconsidered, as their usefulness is not the same for all phenotypes in relation to the risk of cardiovascular disease. Aim: We analyzed the changes in metabolic parameters after a fat overload in different groups of patients.
   Materials and methods: The study included 20 healthy persons, 30 metabolic syndrome patients without morbid obesity, 80 metabolic syndrome patients with morbid obesity and 16 patients with morbid obesity without the metabolic syndrome. All the participants received a fat overload of 60 g. Measurements were made before the overload and 3 h afterwards of triglycerides, free fatty acids, insulin and uric acid.
   Results: Metabolic syndrome patients with morbid obesity had a lower waist-to-hip ratio, and lower plasma free fatty acid and triglycerides levels at baseline and after the overload than patients without morbid obesity. Plasma uric acid levels rose after the fat overload in the metabolic syndrome patients who had morbid obesity but not in the patients without morbid obesity. A positive relation was found between plasma triglycerides and free fatty acid levels in all the patients but not in the controls after the fat overload. A positive relation was also found between uric acid and insulin levels in the metabolic syndrome patients with morbid obesity.
   Conclusions: Metabolic syndrome patients with and without morbid obesity presented different metabolic characteristics. This suggests that there are 2 different clinical phenotypes, both grouped under the metabolic syndrome umbrella. (C) 2012 SEEN. Published by Elsevier Espana, S.L. All rights reserved.
C1 [Tinahones, Francisco J.; Murri, Mora; Cardona, Fernando] Hosp Clin Univ Virgen de la Victoria, Serv Endocrinol & Nutr, Malaga, Spain.
   [Tinahones, Francisco J.; Garcia-Fuentes, Eduardo; Cardona, Fernando] CIBER Fisiopatol Obesidad & Nutr CB06 03, Malaga, Spain.
   [Garrido-Sanchez, Lourdes] Univ Rovira & Virgili, IISPV, Joan Univ Hosp 23, Endocrinol & Diabet Unit, E-43007 Tarragona, Spain.
   [Garrido-Sanchez, Lourdes] CIBER Diabet & Enfermedades Metab Asociadas CIBER, Malaga, Spain.
   [Garcia-Fuentes, Eduardo; Cardona, Fernando] Inst Invest Biomed Malaga IBIMA, Malaga, Spain.
   [Garcia-Fuentes, Eduardo] Hosp Reg Univ Carlos Haya, Serv Endocrinol & Nutr, Malaga, Spain.
C3 CIBER - Centro de Investigacion Biomedica en Red; CIBEROBN; Universitat
   Rovira i Virgili; Institut d'Investigacio Sanitaria Pere Virgili
   (IISPV); CIBER - Centro de Investigacion Biomedica en Red; CIBERES;
   Instituto de Investigacion Biomedica de Malaga y Plataforma en
   Nanomedicina (IBIMA); Universidad de Malaga; Hospital Carlos Haya
RP García-Fuentes, E (corresponding author), CIBER Fisiopatol Obesidad & Nutr CB06 03, Malaga, Spain.
EM edugf1@gmail.com; fernandocardonadiaz@gmail.com
RI Cardona, Fernando/AAG-7835-2019; Garcia-Fuentes, Eduardo/AAB-1607-2020;
   Tinahones, Francisco/AAB-2882-2020; Cardona, Fernando/H-6022-2015
OI GARCIA-FUENTES, EDUARDO/0000-0002-3491-2724; Murri,
   Mora/0000-0002-6482-192X; Tinahones, Francisco J/0000-0001-6871-4403;
   Cardona, Fernando/0000-0003-4460-6824
FU Instituto de Salud Carlos III [CP07/0095, CP04/0133, PI08/1655]; MCYT
   [SAF 2006/12894]; Servicio Andaluz de Salud [0438/2006, 0255/2007,
   PI0325/08]; Programa Juan de la Cierva [JCI-2009-04086]; Research
   Stabilization Program of the Instituto de Salud Carlos III (ISCIII)
FX The authors wish to thank all the subjects for their collaboration, and
   IBIMA. We also gratefully acknowledge the help of Ian Johnstone for his
   expertise in preparing this manuscript. This work was supported in part
   by a grant from the Instituto de Salud Carlos III (CP07/0095, CP04/0133,
   PI08/1655), MCYT (SAF 2006/12894) and Servicio Andaluz de Salud
   (0438/2006, 0255/2007 and PI0325/08). L. Garrido-Sanchez is supported by
   a fellowship from the Programa Juan de la Cierva (JCI-2009-04086). E.
   Garcia-Fuentes is supported by the Research Stabilization Program of the
   Instituto de Salud Carlos III (ISCIII). CIBER Fisiopatologia de la
   Obesidad y Nutricion (CIBEROBN) and CIBER de Diabetes y Enfermedades
   Metabolicas Asociadas (CIBERDEM) are ISCIII projects.
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NR 38
TC 6
Z9 6
U1 0
U2 7
PU ELSEVIER ESPANA SLU
PI BARCELONA
PA AV JOSEP TARRADELLAS, 20-30, 1ERA PLANTA, BARCELONA, CP-08029, SPAIN
SN 1575-0922
EI 1579-2021
J9 ENDOCRINOL NUTR
JI Endocrinol. Nutr.
PD MAR
PY 2013
VL 60
IS 3
BP 127
EP 135
PG 9
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA V43XP
UT WOS:000209714400004
PM 23266153
DA 2025-06-11
ER

PT J
AU Ekmekcioglu, C
AF Ekmekcioglu, Cem
TI Are proinflammatory cytokines involved in an increased risk for
   depression by unhealthy diets?
SO MEDICAL HYPOTHESES
LA English
DT Article
ID C-REACTIVE PROTEIN; METABOLIC SYNDROME; MAJOR DEPRESSION; FATTY-ACIDS;
   SYSTEMIC INFLAMMATION; GLYCEMIC INDEX; WOMEN; SYMPTOMS; PATTERNS;
   MARKERS
AB Depression is a highly prevalent mental illness, which is associated with substantial functional impairment. Many factors, like especially genetic risk and stressful life events, are being discussed to be involved in the pathogenesis of the disease. There is also evidence that elevated levels of proinflammatory cytokines, which are frequently found in depressed individuals, could contribute to the development of the disease. Patients with metabolic syndrome also show a chronic low grade of inflammation. In addition, epidemiological studies suggest that an unhealthy dietary eating pattern, consisting of high amounts of refined grains and softdrinks, red and processed meat, fatty dairy products, and little amounts of vegetables, fruits and fish is associated with higher levels of major inflammatory cytokines, like Interleukin-6, and the acute phase C-reactive protein, even after controlling for body mass index. Furthermore, several recent studies suggest that an unhealthy diet quality is associated with an increased risk of depression. Therefore the connection between regular consumption of unhealthy foods, chronic inflammation, and increased risk for depression seems plausible. (C) 2011 Elsevier Ltd. All rights reserved.
C1 [Ekmekcioglu, Cem] Med Univ Vienna, Ctr Physiol & Pharmacol, Inst Physiol, A-1090 Vienna, Austria.
   [Ekmekcioglu, Cem] Ludwig Boltzmann Gesell, Cluster Rheumatol Balneol & Rehabil, A-1090 Vienna, Austria.
C3 Medical University of Vienna; Ludwig Boltzmann Institute
RP Ekmekcioglu, C (corresponding author), Med Univ Vienna, Ctr Physiol & Pharmacol, Inst Physiol, Schwarzspanierstr 17, A-1090 Vienna, Austria.
EM cem.ekmekcioglu@meduniwien.ac.at
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NR 46
TC 14
Z9 14
U1 0
U2 12
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0306-9877
J9 MED HYPOTHESES
JI Med. Hypotheses
PD FEB
PY 2012
VL 78
IS 2
BP 337
EP 340
DI 10.1016/j.mehy.2011.11.015
PG 4
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 898KP
UT WOS:000300741600033
PM 22153575
DA 2025-06-11
ER

PT J
AU De Vriendt, T
   Moreno, LA
   De Henauw, S
AF De Vriendt, T.
   Moreno, L. A.
   De Henauw, S.
TI Chronic stress and obesity in adolescents: Scientific evidence and
   methodological issues for epidemiological research
SO NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
LA English
DT Review
DE Chronic stress; Obesity; Adolescents; Methodology; Epidemiology
ID SALIVARY CORTISOL; PHYSICAL-ACTIVITY; BLOOD-PRESSURE; PSYCHOLOGICAL
   STRESS; METABOLIC SYNDROME; SELF-REPORT; HEALTH; QUESTIONNAIRE;
   CHILDREN; MEN
AB Aims: This review describes the role of chronic stress in the development of obesity and available methodologies for the assessment of chronic stress in humans, in particular adolescents, with the aim of developing a feasible methodology to implement in an epidemiological study.
   Data synthesis: Chronic stress seems to be associated with the aetiology of obesity by interacting with both mechanisms of energy intake (increase of appetite and energy intake) and expenditure (decrease of physical activity) and by stimulating visceral. fat accumulation in favour of abdominal obesity. However, more research is necessary to unravel the underlying mechanisms of the obesity-inducing effects of chronic stress, especially in adolescents. In addition to experimental research, epidemiological observational. studies, in particular cohort studies, are appropriate given their non-intervening character, tower budgetary costs and natural setting. In practice, stress can be assessed by means of either a subjective approach using stressor checklists or interviews, or an objective approach measuring biomarkers of stress. In epidemiological research in adolescents, a combination of both strategies is recommended, with a preference for a general stressor checklist for adolescents and measurement of salivary cortisol, one of the most used and well-characterized biomarkers of stress.
   Conclusion: This review provides basic evidence for the positive association between chronic stress and obesity, but also points out the need for more research in adolescents to further elucidate the role of chronic stress in the aetiology of obesity in this crucial life period. Good, well-standardized epidemiological surveys could be of great benefit in this research area. (C) 2009 Elsevier B.V. All rights reserved.
C1 [De Vriendt, T.; De Henauw, S.] Univ Ghent, Univ Hosp, Dept Publ Hlth, B-9000 Ghent, Belgium.
   [Moreno, L. A.] Univ Zaragoza, GENUD Res Grp, EU Ciencias Salud, E-50009 Zaragoza, Spain.
   [De Henauw, S.] Hogesch Gent, Dept Hlth Sci, B-9000 Ghent, Belgium.
C3 Ghent University; Ghent University Hospital; University of Zaragoza;
   Leibniz Association; Leibniz Institute for Prevention Research &
   Epidemiology (BIPS); Ghent University
RP De Vriendt, T (corresponding author), Univ Ghent, Univ Hosp, Dept Publ Hlth, Block A,2nd Floor,Pintelaan 185, B-9000 Ghent, Belgium.
EM tineke.devriendt@ugent.be
RI Moreno, Luis/S-1780-2019
OI Moreno Aznar, Luis A./0000-0003-0454-653X
FU Research Foundation - Flanders (Fonds voor Wetenschappelijk Onderzoek
   (FWO) - Vlaanderen); European Community [FOOD-CT-2005-007034]
FX Tineke De Vriendt is funded as aspirant by the Research Foundation -
   Flanders (Fonds voor Wetenschappelijk Onderzoek (FWO) - Vlaanderen). The
   HELENA Study takes place with the financial support of the European
   Community Sixth RTD Framework Programme (Contract FOOD-CT-2005-007034).
   The content of this article reflects only the author's views and the
   European Community is not liable for any use that may be made of the
   information contained herein.
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NR 70
TC 123
Z9 143
U1 0
U2 44
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0939-4753
EI 1590-3729
J9 NUTR METAB CARDIOVAS
JI Nutr. Metab. Carbiovasc. Dis.
PD SEP
PY 2009
VL 19
IS 7
BP 511
EP 519
DI 10.1016/j.numecd.2009.02.009
PG 9
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism; Nutrition
   & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism;
   Nutrition & Dietetics
GA 485ES
UT WOS:000269104400010
PM 19362453
DA 2025-06-11
ER

PT J
AU Bartels-Velthuis, AA
   Visser, E
   Arends, J
   Pijnenborg, GHM
   Wunderink, L
   Jörg, F
   Veling, W
   Liemburg, EJ
   Castelein, S
   Knegtering, H
   Bruggeman, R
AF Bartels-Velthuis, Agna A.
   Visser, Ellen
   Arends, Johan
   Pijnenborg, Gerdina H. M.
   Wunderink, Lex
   Jorg, Frederike
   Veling, Wim
   Liemburg, Edith J.
   Castelein, Stynke
   Knegtering, Henderikus
   Bruggeman, Richard
TI Towards a comprehensive routine outcome monitoring program for people
   with psychotic disorders: The Pharmacotherapy Monitoring and Outcome
   Survey (PHAMOUS)
SO SCHIZOPHRENIA RESEARCH
LA English
DT Article
DE Severe mental illness; Routine outcome monitoring; Cardiovascular
   diseases; Metabolic syndrome; Quality of life
ID SEVERE MENTAL-ILLNESS; METABOLIC SYNDROME; CANNABIS USE; SUBJECTS
   RESPONSE; RISK-FACTORS; SCHIZOPHRENIA; ASSOCIATION; HEALTH;
   METAANALYSIS; NETHERLANDS
AB Background: Patients with psychotic disorders are at risk of developing mental health and social problems, and physical disorders. To monitor and treat these problems when indicated, an annual routine outcome monitoring program, Pharmacotherapy Monitoring and Outcome Survey (PHAMOUS), was developed. This paper presents the background and content of PHAMOUS, implementation of PHAMOUS, characteristics of the patients screened in 2015, and the outcome of patients with three annual screenings between 2011 and 2015.
   Methods: PHAMOUS was implemented in four mental health institutions in the Northern Netherlands in 2006. During the PHAMOUS screening, patients are assessed on socio- demographics, psychiatric symptoms, medication, physical parameters, lifestyle, (psycho) social functioning and quality of life, using internationally validated instruments.
   Results: In 2015, 1955 patients with psychotic disorders were enrolled in the PHAMOUS screening. The majority (72%) was receiving mental healthcare for ten years or longer. A small group was hospitalized (10%) in the past year. Half of the patients were in symptomatic remission. Less than 10% had a paid job. More than half of the patients fulfilled the criteria for metabolic syndrome (54%). The subsamplewith three annual screenings from2011 to 2015 (N= 1230) was stable, except the increasing prevalence of high glucose levels and satisfaction with social relationships (Cochran's Q= 16.33, p=. 001 resp. Q= 14.79, p =.001).
   Conclusion: The annual PHAMOUS screening enables to follow themental, physical and social health problems of patients, which offers a good basis for shared- decision making with regard to updating the annual treatment plan, next to a wealth of data for scientific research. (C) 2018 Elsevier B. V. All rights reserved.
C1 [Bartels-Velthuis, Agna A.; Visser, Ellen; Jorg, Frederike; Liemburg, Edith J.; Knegtering, Henderikus; Bruggeman, Richard] Univ Groningen, Univ Med Ctr Groningen, Univ Ctr Psychiat, Rob Giel Res Ctr, Hanzepl 1,CC72, NL-9713 GZ Groningen, Netherlands.
   [Bartels-Velthuis, Agna A.; Castelein, Stynke; Knegtering, Henderikus] Lentis Mental Hlth Inst, Hereweg 80, NL-9725 AG Groningen, Netherlands.
   [Arends, Johan; Pijnenborg, Gerdina H. M.] GGZ Drenthe, Mental Hlth Inst, Dennenweg 9, NL-9404 LA Assen, Netherlands.
   [Pijnenborg, Gerdina H. M.] Univ Groningen, Fac Behav & Social Sci, Dept Clin Psychol & Expt Psychopathol, Grote Kruisstr 2-1, NL-9712 TS Groningen, Netherlands.
   [Wunderink, Lex; Jorg, Frederike] GGZ Friesland Mental Hlth Inst, Sixmastr 2, NL-8932 PA Leeuwarden, Netherlands.
   [Veling, Wim] Univ Groningen, Univ Med Ctr Groningen, Univ Ctr Psychiat, Psychosis Dept, Hanzepl 1,CC60, NL-9713 GZ Groningen, Netherlands.
   [Bruggeman, Richard] Univ Groningen, Univ Med Ctr Groningen, Dept Pharm, Div Pharmacotherapy & Pharmaceut Care, A Deusinglaan 1, NL-9713 AV Groningen, Netherlands.
C3 University of Groningen; University of Groningen; University of
   Groningen; University of Groningen
RP Bruggeman, R (corresponding author), Univ Groningen, Univ Med Ctr Groningen, Univ Ctr Psychiat, Rob Giel Res Ctr, Hanzepl 1,CC72, NL-9713 GZ Groningen, Netherlands.
EM a.a.bartels@umcg.nl; e.visser03@umcg.nl; johan.arends@ggzdrenthe.nl;
   g.h.m.pijnenborg@rug.nl; lex.wunderink@ggzfriesland.nl; f.jorg@umcg.nl;
   w.veling@umcg.nl; e.j.liemburg@umcg.nl; s.castelein@lentis.nl;
   h.knegtering@lentis.nl; r.bruggeman@umcg.nl
RI Wunderink, Lex/H-8235-2019; Pijnenborg, Gerdina/A-7437-2011; van Os,
   Jim/V-8884-2019; Jörg, Frederike/B-1325-2014
OI Castelein, Stynke/0000-0002-8419-568X; Visser,
   Ellen/0000-0002-6370-5484; Jorg, Frederike/0000-0003-1720-1231; Veling,
   Wim/0000-0002-1364-9779
FU Lentis; GGZ Friesland; GGZ Drenthe; Mediant; Dimence Groep; University
   Center for Psychiatry of the University Medical Center Groningen
FX The Rob Giel Research center is structurally funded by the following
   mental health organizations: Lentis, GGZ Friesland, GGZ Drenthe,
   Mediant, Dimence Groep, and the University Center for Psychiatry of the
   University Medical Center Groningen.
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NR 46
TC 26
Z9 26
U1 0
U2 2
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0920-9964
EI 1573-2509
J9 SCHIZOPHR RES
JI Schizophr. Res.
PD JUL
PY 2018
VL 197
BP 281
EP 287
DI 10.1016/j.schres.2018.01.016
PG 7
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA GM0YE
UT WOS:000437786100042
PM 29395613
OA Green Published
DA 2025-06-11
ER

PT J
AU Vieweg, WVR
   Levy, JR
   Fredrickson, SK
   Chipkin, SR
   Beatty-Brooks, M
   Fernandez, A
   Hasnain, M
   Pandurangi, AK
AF Vieweg, W. Victor R.
   Levy, James R.
   Fredrickson, Sonja K.
   Chipkin, Stuart R.
   Beatty-Brooks, Mary
   Fernandez, Antony
   Hasnain, Mehrul
   Pandurangi, Anand K.
TI Psychotropic drug considerations in depressed patients with metabolic
   disturbances
SO AMERICAN JOURNAL OF MEDICINE
LA English
DT Review
DE depression; diabetes mellitus; metabolic syndrome; obesity; psychotropic
   drugs
ID INDUCED WEIGHT-GAIN; STAR-ASTERISK-D; SEQUENCED TREATMENT ALTERNATIVES;
   BODY-MASS INDEX; DIABETES-MELLITUS; PHARMACOLOGICAL MANAGEMENT; 2ND-STEP
   TREATMENTS; MOOD DISORDERS; OBESITY; ANTIPSYCHOTICS
AB primary care. The prevalence of each condition separately does not explain the frequency of their co-occurrence. Depression may lead to or exacerbate these endocrine and metabolic conditions. Conversely, these medical conditions may lead to or exacerbate depression. Psychotropic drugs that treat depression may increase appetite with resultant weight gain. Rarely, such agents may be associated with weight loss. We review the potential for psychotropic drugs to alter body weight and provide a figure as a guide to drug selection. Unless circumstances dictate otherwise, clinicians should select psychotropic drugs least likely to induce weight gain when treating depressed patients with obesity, diabetes mellitus, or the metabolic syndrome. Even drugs generally thought to be "weight neutral" may occasionally be associated with weight gain. Thus, alerting patients to this potential and due diligence form the cornerstone of weight management in the depressed patient. (c) 2008 Elsevier Inc. All rights reserved.
C1 [Vieweg, W. Victor R.; Fernandez, Antony] Hunter Holmes McGuire Vet Affairs Med Ctr, Psychiat Serv, Richmond, VA USA.
   [Vieweg, W. Victor R.; Levy, James R.; Fredrickson, Sonja K.] Hunter Holmes McGuire Vet Affairs Med Ctr, Med Serv, Richmond, VA USA.
   [Vieweg, W. Victor R.; Fernandez, Antony; Pandurangi, Anand K.] Virginia Commonwealth Univ, Dept Psychiat, Med Coll Virginia Campus, Richmond, VA 23284 USA.
   [Vieweg, W. Victor R.; Levy, James R.; Fredrickson, Sonja K.] Virginia Commonwealth Univ, Dept Internal Med, Med Coll Virginia Campus, Richmond, VA 23284 USA.
   [Chipkin, Stuart R.] Univ Massachusetts, Sch Publ Hlth & Hlth Sci, Amherst, MA 01003 USA.
   [Hasnain, Mehrul] Sir Thomas Roddick Hosp, Western Reg Integrated Hlth Author, Dept Psychiat, Stephenville, NF, Canada.
C3 Hunter Holmes McGuire Veterinary Affairs Medical Center; Hunter Holmes
   McGuire Veterinary Affairs Medical Center; Virginia Commonwealth
   University; Virginia Commonwealth University; University of
   Massachusetts System; University of Massachusetts Amherst
RP Vieweg, WVR (corresponding author), 17 Runswick Dr, Richmond, VA 23238 USA.
EM vvieweg@visi.net
RI Lam, Raymond/D-2529-2013; Hasnain, Mehrul/S-7158-2019
OI Chipkin, Stuart/0000-0003-2114-9480
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NR 96
TC 19
Z9 21
U1 0
U2 11
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0002-9343
EI 1555-7162
J9 AM J MED
JI Am. J. Med.
PD AUG
PY 2008
VL 121
IS 8
BP 647
EP 655
DI 10.1016/j.amjmed.2007.08.043
PG 9
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 344WD
UT WOS:000258957100003
PM 18691474
DA 2025-06-11
ER

PT J
AU Leak-Johnson, T
   Yan, FX
   Daniels, P
AF Leak-Johnson, Tennille
   Yan, Fengxia
   Daniels, Pamela
TI What the Jackson Heart Study Has Taught Us About Diabetes and
   Cardiovascular Disease in the African American Community: a 20-year
   Appreciation
SO CURRENT DIABETES REPORTS
LA English
DT Review
DE Jackson Heart Study; Type 2 diabetes; Cardiovascular disease; African
   Americans; Neighborhoods; Risk factors
ID GENOME-WIDE ASSOCIATION; NEIGHBORHOOD DISADVANTAGE; PHYSICAL-ACTIVITY;
   TCF7L2 GENE; RISK; HEALTH; OUTCOMES; STRESS; MELLITUS; EVENTS
AB Purpose of Review The burden of cardiometabolic diseases such as cardiovascular disease (CVD) and type 2 diabetes (T2D) is pronounced among African Americans. Research has shown that behavioral, social, metabolic, psychosocial, and genetic risk factors of CVD and T2D are closely interwoven. Approximately 20 years ago, the Jackson Heart Study (JHS) was established to investigate this constellation of risk factors. Recent Findings Findings from neighborhood studies emphasize the importance of social cohesion and physical environment in the context CVD and T2D risk. Socioeconomic status factors such as income and education were significant predictors for CVD and T2D. Behavioral studies indicate that modifiable risk factors such as smoking, physical inactivity, lack of sleep, and poor nutrition are associated with CVD risk and all-cause mortality. Mental health also was found to be associated with CVD and T2D. Genetic influences are associated with disease etiology. This review summarizes the joint contributions of CVD and cardiometabolic risk factors in an African American population.
C1 [Leak-Johnson, Tennille] Morehouse Sch Med, Cardiovasc Res Inst, Atlanta, GA 30310 USA.
   [Leak-Johnson, Tennille] Morehouse Sch Med, Dept Physiol, 720 Westview Dr Sw, Atlanta, GA 30310 USA.
   [Yan, Fengxia; Daniels, Pamela] Morehouse Sch Med, Res Design & Biostat Core, Atlanta, GA 30310 USA.
   [Yan, Fengxia] Morehouse Sch Med, Community Hlth & Prevent Med, Atlanta, GA 30310 USA.
C3 Morehouse School of Medicine; Morehouse School of Medicine; Morehouse
   School of Medicine; Morehouse School of Medicine
RP Leak-Johnson, T (corresponding author), Morehouse Sch Med, Cardiovasc Res Inst, Atlanta, GA 30310 USA.; Leak-Johnson, T (corresponding author), Morehouse Sch Med, Dept Physiol, 720 Westview Dr Sw, Atlanta, GA 30310 USA.
EM tleakjohnson@msm.edu
RI yan, feng/JAX-8275-2023
FU Tougaloo College [HHSN268201800014I]; Mississippi State Department of
   Health [HHSN268201800015I]; University of Mississippi Medical Center
   from the National Heart, Lung, and Blood Institute (NHLBI)
   [HHSN268201800010I, HHSN268201800011I, HHSN268201800012I]; Jackson State
   University [HHSN268201800013I]; University of Mississippi Medical Center
   from National Institute on Minority Health and Health Disparities
   (NIMHD) [HHSN268201800010I, HHSN268201800011I, HHSN268201800012I]
FX The authors wish to thank the staff and participants of the Jackson
   Heart Study (JHS). JHS is supported and conducted in collaboration with
   Jackson State University (HHSN268201800013I), Tougaloo College
   (HHSN268201800014I), the Mississippi State Department of Health
   (HHSN268201800015I), and the University of Mississippi Medical Center
   (HHSN268201800010I, HHSN268201800011I and HHSN268201800012I) contracts
   from the National Heart, Lung, and Blood Institute (NHLBI) and the
   National Institute on Minority Health and Health Disparities (NIMHD).
   The views expressed in this article are those of the authors and do not
   necessarily represent the views of the National Heart, Lung, and Blood
   Institute; the National Institutes of Health; or the US Department of
   Health and Human Services.
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NR 86
TC 5
Z9 6
U1 0
U2 2
PU CURRENT MEDICINE GROUP
PI PHILADELPHIA
PA 400 MARKET STREET, STE 700, PHILADELPHIA, PA 19106 USA
SN 1534-4827
EI 1539-0829
J9 CURR DIABETES REP
JI Curr. Diabetes Rep.
PD OCT
PY 2021
VL 21
IS 10
AR 39
DI 10.1007/s11892-021-01413-4
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism
GA UN1VF
UT WOS:000693809000004
PM 34495422
DA 2025-06-11
ER

PT J
AU Vakil, KP
   Malhotra, S
   Sawada, S
   Campbell, SR
   Sayfo, S
   Kamalesh, M
AF Vakil, Kairav P.
   Malhotra, Saurabh
   Sawada, Stephen
   Campbell, Steffanie R.
   Sayfo, Sameh
   Kamalesh, Masoor
TI Waist Circumference and Metabolic Syndrome: The Risk for Silent Coronary
   Artery Disease in Males
SO METABOLIC SYNDROME AND RELATED DISORDERS
LA English
DT Article
ID UNRECOGNIZED MYOCARDIAL-INFARCTION; TYPE-2 DIABETES-MELLITUS;
   CARDIOVASCULAR-DISEASE; ABDOMINAL OBESITY; AUTONOMIC NEUROPATHY;
   HEART-DISEASE; PREVALENCE; MORTALITY; MEN; DIAGNOSIS
AB Background: Waist circumference (WC) is a component used to define metabolic syndrome. However, its role as an independent predictor of silent coronary artery disease (CAD), above its contribution to metabolic syndrome, remains unknown.
   Methods: Male veterans without known CAD, undergoing cardiac stress testing for indications other than typical angina or its equivalent, were evaluated for the presence of silent CAD. High WC and metabolic syndrome were defined per the revised National Cholesterol Education Program (NCEP-R) and the International Diabetes Federation (IDF) criteria.
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   Conclusion: A WC >= 94 cm in males is independently associated with an increased prevalence of silent CAD. In patients with metabolic syndrome, this prevalence is increased by the presence of high WC.
C1 [Kamalesh, Masoor] Indiana Univ Sch Med, RL Roudebush Vet Affairs Med Ctr, Krannert Inst Cardiol, Indianapolis, IN 46202 USA.
   [Vakil, Kairav P.; Campbell, Steffanie R.; Sayfo, Sameh] Indiana Univ Sch Med, Dept Internal Med, Indianapolis, IN 46202 USA.
C3 US Department of Veterans Affairs; Veterans Health Administration (VHA);
   Richard L. Roudebush VA Medical Center; Indiana University System;
   Indiana University Bloomington; Indiana University System; Indiana
   University Bloomington
RP Kamalesh, M (corresponding author), Indiana Univ Sch Med, RL Roudebush Vet Affairs Med Ctr, Krannert Inst Cardiol, 1481 W 10th St, Indianapolis, IN 46202 USA.
EM mkamales@iupui.edu
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NR 45
TC 7
Z9 9
U1 0
U2 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-4196
EI 1557-8518
J9 METAB SYNDR RELAT D
JI Metab. Syndr. Relat. Disord.
PD JUN
PY 2012
VL 10
IS 3
BP 225
EP 231
DI 10.1089/met.2011.0099
PG 7
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 952DV
UT WOS:000304771300012
PM 22324791
DA 2025-06-11
ER

PT J
AU Miyata, T
   de Strihou, CV
AF Miyata, Toshio
   de Strihou, Charles van Ypersele
TI Translation of basic science into clinical medicine: novel targets for
   diabetic nephropathy
SO NEPHROLOGY DIALYSIS TRANSPLANTATION
LA English
DT Article
DE hypertension; hypoxia; metabolic syndrome; oxidative stress; PAI-1
ID PLASMINOGEN-ACTIVATOR INHIBITOR-1; GLYCATION END-PRODUCTS; RAT MODEL;
   INSULIN-RESISTANCE; RENAL INJURY; STRESS; ACCUMULATION; DEFICIENCY;
   MECHANISMS; ISCHEMIA
C1 [Miyata, Toshio] Tohoku Univ, Grad Sch Med, Ctr Translat & Adv Res, Aoba Ku, Sendai, Miyagi 9808575, Japan.
   Univ Catholique Louvain, Serv Nephrol, B-1200 Brussels, Belgium.
C3 Tohoku University; Universite Catholique Louvain
RP Miyata, T (corresponding author), Tohoku Univ, Grad Sch Med, Ctr Translat & Adv Res, Aoba Ku, 2-1 Seiryo Machi, Sendai, Miyagi 9808575, Japan.
EM t-miyata@mail.tains.tohoku.ac.jp
RI Miyata, Toshio/A-4872-2010
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NR 27
TC 8
Z9 8
U1 0
U2 1
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0931-0509
J9 NEPHROL DIAL TRANSPL
JI Nephrol. Dial. Transplant.
PD MAY
PY 2009
VL 24
IS 5
BP 1373
EP 1377
DI 10.1093/ndt/gfp028
PG 5
WC Transplantation; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Transplantation; Urology & Nephrology
GA 434LA
UT WOS:000265275000007
PM 19211649
OA Bronze
DA 2025-06-11
ER

PT J
AU Brudasca, I
   Cucuianu, M
AF Brudasca, Ioana
   Cucuianu, Mircea
TI Chronic Stress, Neuroendocrine Disorders and Metabolic Syndrome
SO REVISTA ROMANA DE MEDICINA DE LABORATOR
LA English
DT Article
DE stress; hypothalamic-pituitary-adrenocortical axis; metabolic syndrome;
   cortisol secretion; adrenergic stimulation; visceral obesity; free fatty
   acids; polycystic ovary syndrome
ID PITUITARY-ADRENOCORTICAL AXIS; CORONARY-HEART-DISEASE; HUMAN
   ADIPOSE-TISSUE; INSULIN-RESISTANCE; ANGIOTENSIN-II; SALIVARY CORTISOL;
   OBESITY; INTERLEUKIN-6; INFLAMMATION; SECRETION
AB More than 50 years ago clinicians had suggested that frequent association of obesity with arterial hypertension and with atherosclerotic vascular disease should involve some common pathogenic mechanisms including certain neuroendocrine disorders a hypothesis being now supported by experimental and by clinical case-control studies. Daily cortisol secretion measured in saliva had higher levels in subjects at high stress comparativeley to subjects at low stress. A case control study emphasized that when compared to controls, the subjects displaying features of the metabolic syndrome were also presenting higher urinary elimination of cortisol and catecholamines metabolites, as well as higher serum levels of interleukin - 6 and CRP It was therefore concluded that autonomic, adrenocortical and inflammatory causes are involved in the development of metabolic syndrome, which can be a intermediate on the pathway between long term psychosocial stress and coronary artery disease. Visceral obesity may be a target of activated sympathoadrenal system, as adipose tissue of such patients is endowed with numerous highly sensitive beta 3 adrenoreceptors. Subsequent activation of hormone dependent lipase within this hypertrophic adipose tissue would trigger the release of fatty acids into the portal flow leading to hepatic steatosis and insulin resistance. Free fatty acids taken up into specific receptors would stimulate the synthesis of plasminogen activator inhibitor -1 (PAI-1). The interaction of free fatty acids derived from a high fat diet with a G protein-coupled transmembrane receptor (the GPR-40, preferentially expressed on pancreatic beta cells) would mediate an excessively increased glucose stimulated insulin secretion, leading to hyperinsulinemia and metabolic syndrome. Beta adrenergic stimulation would also activate the renin-angiotensin-aldosterone system within adipose tissue of obese patients. Visceral obesity and neuroendocrine disorders are also involved in the pathogenesis of renal disease and in the hyperinsulinemia of women with polycystic ovary syndrome. Elucidating the pathogenesis of metabolic syndrome should promote the initiation of novel therapeutic approaches.
C1 [Brudasca, Ioana; Cucuianu, Mircea] Univ Med & Pharm Iuliu Hatieganu Cluj Napoca, Dept Med Biochem, Cluj Napoca, Romania.
C3 Iuliu Hatieganu University of Medicine & Pharmacy
RP Brudasca, I (corresponding author), Univ Med & Pharm Iuliu Hatieganu Cluj Napoca, Dept Med Biochem, Str Pasteur 6, Cluj Napoca, Romania.
EM ioanabrudasca@yahoo.com
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NR 52
TC 3
Z9 3
U1 0
U2 11
PU UNIV PRESS
PI TIRES MURES
PA UNIV MED FARMACIE TIRGU MURES, DISCIPLINA BIOCHIMIE CLIN, STR GHEORGHE
   MARINESCU, NR 38, TIRES MURES, 00000, ROMANIA
SN 1841-6624
EI 2284-5623
J9 REV ROMANA MED LAB
JI Rev. Romana Med. Lab.
PD SEP
PY 2011
VL 19
IS 3
BP 219
EP 226
PG 8
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 828GG
UT WOS:000295488900001
DA 2025-06-11
ER

PT J
AU Qi, H
   Liu, R
   Dong, CC
   Zhu, XQ
   Feng, Y
   Wang, HN
   Li, L
   Chen, F
   Wang, G
   Yan, F
AF Qi, Han
   Liu, Rui
   Dong, Cheng-Cheng
   Zhu, Xue-Quan
   Feng, Yuan
   Wang, Hai-Ning
   Li, Lei
   Chen, Fei
   Wang, Gang
   Yan, Fang
TI Identifying influencing factors of metabolic syndrome in patients with
   major depressive disorder: A real-world study with Bayesian network
   modeling
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Major depressive disorder; Metabolic syndrome; Bayesian network;
   Real-world data; Influencing factors
ID MENTAL-DISORDERS; PREVALENCE; ASSOCIATION; HEALTH; RISK
AB Background: The bidirectional relationships between metabolic syndrome (MetS) and major depressive disorder (MDD) were discovered, but the influencing factors of the comorbidity were barely investigated. We aimed to fully explore the factors and their associations with MetS in MDD patients. Methods: The data were retrieved from the electronic medical records of a tertiary psychiatric hospital in Beijing from 2016 to 2021. The influencing factors were firstly explored by univariate analysis and multivariate logistic regressions. The propensity score matching was used to reduce the selection bias of participants. Then, the Bayesian networks (BNs) with hill-climbing algorithm and maximum likelihood estimation were preformed to explore the relationships between influencing factors with MetS in MDD patients. Results: Totally, 4126 eligible subjects were included in the data analysis. The proportion rate of MetS was 32.6 % (95 % CI: 31.2 %-34.1 %). The multivariate logistic regression suggested that recurrent depression, uric acid, duration of depression, marriage, education, number of hospitalizations were significantly associated with MetS. In the BNs, number of hospitalizations and uric acid were directly connected with MetS. Recurrent depression and family history psychiatric diseases were indirectly connected with MetS. The conditional probability of MetS in MDD patients with family history of psychiatric diseases, recurrent depression and two or more times of hospitalizations was 37.6 %. Conclusion: Using the BNs, we found that number of hospitalizations, recurrent depression and family history of psychiatric diseases contributed to the probability of MetS, which could help to make health strategies for specific MDD patients.
C1 [Qi, Han; Liu, Rui; Dong, Cheng-Cheng; Zhu, Xue-Quan; Feng, Yuan; Wang, Gang; Yan, Fang] Capital Med Univ, Beijing Anding Hosp, Natl Clin Res Ctr Mental Disorders, Beijing Key Lab Mental Disorders, Beijing, Peoples R China.
   [Qi, Han; Liu, Rui; Dong, Cheng-Cheng; Zhu, Xue-Quan; Feng, Yuan; Wang, Gang; Yan, Fang] Capital Med Univ, Beijing Anding Hosp, Natl Ctr Mental Disorders, Beijing, Peoples R China.
   [Qi, Han; Liu, Rui; Dong, Cheng-Cheng; Zhu, Xue-Quan; Feng, Yuan; Wang, Gang; Yan, Fang] Capital Med Univ, Adv Innovat Ctr Human Brain Protect, Beijing 100088, Peoples R China.
   [Wang, Hai-Ning] Peking Univ Third Hosp, Dept Endocrinol & Metab Dis, Beijing, Peoples R China.
   [Li, Lei] Peking Univ Third Hosp, Dept Cardiol, Beijing, Peoples R China.
   [Chen, Fei] Peking Univ, Peking Univ Hlth Sci Ctr, Grad Sch, Beijing, Peoples R China.
   [Li, Lei] Peking Univ, State Key Lab Vasc Homeostasis & Remodeling, Beijing, Peoples R China.
   [Li, Lei] Peking Univ, NHC Key Lab Cardiovasc Mol Biol & Regulatory Pepti, Beijing, Peoples R China.
   [Li, Lei] Beijing Key Lab Cardiovasc Receptors Res, Beijing, Peoples R China.
C3 Capital Medical University; Capital Medical University; Capital Medical
   University; Peking University; Peking University; Peking University;
   Peking University
RP Wang, G; Yan, F (corresponding author), Capital Med Univ, Adv Innovat Ctr Human Brain Protect, Beijing 100088, Peoples R China.; Wang, G; Yan, F (corresponding author), Capital Med Univ, Natl Clin Res Ctr Mental Disorders, Beijing 100088, Peoples R China.; Wang, G; Yan, F (corresponding author), Capital Med Univ, Beijing Anding Hosp, Beijing Key Lab Mental Disorders, Beijing 100088, Peoples R China.
EM gangwangdoc@ccmu.edu.cn; yanfang2019@ccmu.edu.cn
RI QI, Han/ABC-6252-2020; Wang, Gang/MYQ-4807-2025; Chen, Fei/HGE-5690-2022
FU Taikang Yicai Public Welfare Foundation [ZXJJ-YCGW-010 (57)]; Beijing
   Hospitals Authority Youth Programme [QML20231905]; Beijing High level
   Public Health Technical Talents Training Plan [xuekedaitouren-01-30]
FX This work was supported by the Taikang Yicai Public Welfare Foundation
   (FY, grant number ZXJJ-YCGW-010 (57) ) ; Beijing Hospitals Authority
   Youth Programme (HQ, grant number QML20231905) ; and the Beijing High
   level Public Health Technical Talents Training Plan (FY, grant number
   xuekedaitouren-01-30) .
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NR 51
TC 0
Z9 0
U1 5
U2 8
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD OCT 1
PY 2024
VL 362
BP 308
EP 316
DI 10.1016/j.jad.2024.07.004
EA JUL 2024
PG 9
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA K9J8W
UT WOS:001346997500001
PM 38971193
DA 2025-06-11
ER

PT J
AU Tocco, M
   Newcomer, JW
   Mao, YC
   Pikalov, A
AF Tocco, Michael
   Newcomer, John W.
   Mao, Yongcai
   Pikalov, Andrei
TI Lurasidone and risk of metabolic syndrome: results from short and
   long-term studies in patients with bipolar depression
SO CNS SPECTRUMS
LA English
DT Article
DE Atypical antipsychotic; lurasidone; bipolar disorder; depressive
   disorder; metabolic syndrome
ID DOUBLE-BLIND; I DEPRESSION; CARDIOVASCULAR-DISEASE; INSULIN-RESISTANCE;
   DISORDER; SCHIZOPHRENIA; PREVALENCE; LITHIUM; VALPROATE; 12-MONTH
AB ObjectiveThe elevated prevalence of metabolic syndrome (MetS) in patients with depression has been associated with increased mortality. This post hoc analysis assessed the effect of treatment with lurasidone on risk of MetS in patients with bipolar depression. MethodsData used in the current analyses consisted of 3 double-blind (DB), placebo-controlled, 6-week studies in adults with bipolar I depression (N = 1192), consisting of 1 monotherapy, and 2 adjunctive trials (lithium or valproate). Also analyzed was a 6-month open-label (OL) extension study (monotherapy, N = 316; adjunctive therapy, N = 497); and a 5-month, OL, stabilization phase followed by randomization to a 28-week DB, placebo-controlled, adjunctive therapy study with lurasidone (N = 490). MetS was defined based on NCEP ATP III criteria (2005 revision). ResultsThe proportion of patients with new-onset MetS was similar for lurasidone vs placebo in the short-term studies (monotherapy, 13.9% vs 15.3%; adjunctive therapy, 13.6% vs 11.0%); and remained stable during both the 6-month extension phase study (monotherapy, 15.2%; adjunctive therapy, 16.9%), and the 5-month stabilization study (adjunctive therapy, 12.2%). After 28 weeks of DB treatment (following 5-month treatment in the stabilization study), new onset MetS was observed at endpoint (OC) in 26.2% of the lurasidone group, and 30.8% of the placebo group. ConclusionsThis post hoc analysis found that both short and long-term treatment with lurasidone was associated with a relatively low risk for the development of MetS in patients with bipolar I disorder. These findings are consistent with similar analyses in patients with schizophrenia.
C1 [Tocco, Michael; Mao, Yongcai; Pikalov, Andrei] Sunovion Pharmaceut Inc, Ft Lee, NJ 07024 USA.
   [Tocco, Michael; Mao, Yongcai; Pikalov, Andrei] Sunovion Pharmaceut Inc, Marlborough, MA 01752 USA.
   [Newcomer, John W.] Thriving Mind South Florida, Miami, FL USA.
   [Newcomer, John W.] Washington Univ, Sch Med, Dept Psychiat, St Louis, MO USA.
C3 Dainippon Sumitomo Pharmaceutical Company; Sunovion Pharmaceuticals
   Inc.; Dainippon Sumitomo Pharmaceutical Company; Sunovion
   Pharmaceuticals Inc.; Washington University (WUSTL)
RP Tocco, M (corresponding author), Sunovion Pharmaceut Inc, Ft Lee, NJ 07024 USA.; Tocco, M (corresponding author), Sunovion Pharmaceut Inc, Marlborough, MA 01752 USA.
EM Michael.Tocco@sunovion.com
FU Sunovion Pharmaceuticals Inc., Marlborough, MA; Sunovion Pharmaceuticals
   Inc
FX Edward Schweizer of Paladin Consulting Group provided medical writing
   and editorial assistance for this manuscript that was funded by Sunovion
   Pharmaceuticals Inc., Marlborough, MA. Clinical research was sponsored
   by Sunovion Pharmaceuticals Inc. The sponsor was involved in the study
   design, collection, and analysis of data. The interpretation of results
   and the decision to submit this manuscript for publication were made by
   the authors independently.
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NR 65
TC 3
Z9 3
U1 1
U2 2
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 1092-8529
EI 2165-6509
J9 CNS SPECTRUMS
JI CNS Spectr.
PD DEC
PY 2023
VL 28
IS 6
BP 680
EP 687
AR PII S1092852923001190
DI 10.1017/S1092852923001190
EA MAR 2023
PG 8
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Psychiatry
GA CA2X7
UT WOS:000955744700001
PM 36961124
OA hybrid
DA 2025-06-11
ER

PT J
AU Goyal, R
   Singhai, M
   Mahmood, T
   Saxena, V
AF Goyal, Rajeev
   Singhai, Monil
   Mahmood, Tariq
   Saxena, Vartika
TI Association between the physical activity and metabolic syndrome in
   residents of a foot-hill area in India
SO DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS
LA English
DT Article
DE Physical activity; Metabolic syndrome; Global physical activity
   questionnaire
ID MORTALITY
AB Background and aims: Physical inactivity, has been linked to development of metabolic syndrome, which increases the risk of developing cardiovascular disease. Aim of the study was to assess the level of physical activity and it's association with prevalence of metabolic syndrome and oxidative stress in a semiurban foothill population of India. Methods: Participants (n 1/4 288), > 18 years of age were enrolled. Their demographics and clinical details were recorded. Fasting plasma glucose, triglycerides, cholesterol and erythrocyte glutathione peroxidase activity were measured. Physical activity was estimated using Global Physical Activity Questionnaire and converted into metabolic equivalent in minutes per week. Results: 37.5% of study population was found to be physically active, with more males (43.3%) being active than females (23.3%). Inactivity was associated with higher triglycerides levels in males and with higher hip circumference, diastolic blood pressure, triglycerides and fasting plasma glucose in females. No significant difference was found in the oxidative stress, indicated by decreased glutathione peroxidase activity, between active and inactive persons or persons with normal and increased body mass index. Conclusions: There is a high prevalence of physical inactivity in this region of India, with prevalence of physical inactivity higher is females as compared to males. No significant co-relation was found between the levels of activity and components of metabolic syndrome and oxidative stress in the study population. (C) 2022 Published by Elsevier Ltd on behalf of Diabetes India.
C1 [Goyal, Rajeev] AIIMS, Dept Biochem, Rishikesh, India.
   [Singhai, Monil] Natl Ctr Dis Control, Ctr Arboviral & Zoonot Dis, New Delhi, India.
   [Mahmood, Tariq] Sri Ram Murti Smarak Inst Med Sci, Dept Biochem, Bareilly, Uttar Pradesh, India.
   [Saxena, Vartika] AIIMS, Dept Community & Family Med, Rishikesh, India.
C3 All India Institute of Medical Sciences (AIIMS) Rishikesh; National
   Centre for Disease Control (NCDC); All India Institute of Medical
   Sciences (AIIMS) Rishikesh
RP Goyal, R (corresponding author), Lady Hardinge Med Coll & Hosp, Dept Biochem, New Delhi 110001, India.
EM docrajeev@gmail.com
RI Saxena, Vartika/IST-9125-2023
OI Singhai, Monil/0000-0003-1595-3798; Mahmood, Dr
   Tariq/0000-0002-8492-0175; GOYAL, RAJEEV/0000-0002-1023-2070
FU All India Institute of Medical Sciences, Rishikesh, India
   [IEC/IM/05/RC/04]
FX We acknowledge financial support from All India Institute of Medical
   Sciences, Rishikesh, India, through intramural project (Reference No.
   IEC/IM/05/RC/04) .
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NR 28
TC 1
Z9 1
U1 0
U2 3
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1871-4021
EI 1878-0334
J9 DIABETES METAB SYND
JI Diabetes Metab. Syndr.-Clin. Res. Rev.
PD APR
PY 2022
VL 16
IS 4
AR 102471
DI 10.1016/j.dsx.2022.102471
EA MAR 2022
PG 5
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA 1U5EU
UT WOS:000805436700004
PM 35367911
DA 2025-06-11
ER

PT J
AU Ahn, TY
   Park, JK
   Lee, SW
   Hong, JH
   Park, NC
   Kim, JJ
   Park, K
   Park, H
   Hyun, JS
AF Ahn, Tai Young
   Park, Jong Kwan
   Lee, Sung Won
   Hong, Jun Hyuk
   Park, Nam Cheol
   Kim, Je Jong
   Park, Kwangsung
   Park, Hyesook
   Hyun, Jae Seog
TI Prevalence and risk factors for erectile dysfunction in Korean men:
   Results of an epidemiological study
SO JOURNAL OF SEXUAL MEDICINE
LA English
DT Article
DE erectile dysfunction; Koreans; premature ejaculation; prevalence; risk
   factor
ID HELP-SEEKING PATTERNS; AGED 40-80 YEARS; PREMATURE EJACULATION;
   METABOLIC SYNDROME; POPULATION; ATTITUDES; OLDER
AB Introduction. The prevalence of erectile dysfunction (ED) and associated risk factors has been described in many countries, but there are still only a few studies from Asia.
   Aim. We investigated the prevalences of ED and premature ejaculation (PE) in Korean men and the impact of general health, lifestyle, and psvchosocial factors on these conditions.
   Methods. To assess ED and PE, 1,570 Korean men aged 40-79 years were interviewed with a self-administered questionnaire on sexual function and the International Index of Erectile Function (IIEF)-5. In addition, blood chemistry was analyzed for each subject.
   Main outcome Measures. The prevalences of ED and PE were obtained from self-reported ED, IIEF-5 scoring, EF (erectile function) domain scoring, and self-reported intravaginal ejaculatory latency time (IELT). The data were analyzed for the presence of risk factors and the relationship of general health, lifestyle, and psychosocial factors with ED.
   Results. The prevalences of ED among Korean men were 13.4% (self-reported ED) and 32.4% (IIEF-5 score <= 17), and PE prevalences were 11% JELT <= 2-min) and 33.1% (IELT <= 5-min). ED was more prevalent in the subject groups with older age, lower income, or lower education, and in subjects without a spouse. ED prevalence was positively associated with risk factors such as diabetes, hypertension, heart disease, psychological stress, and obesity Levels of serum hemoglobin (Hb) Alc, triglycerides, testosterone, or dehydroepiandrosterone sulfate (DHEA-S) were significantly different between the ED and non-ED groups.
   Conclusions. The prevalences of ED and PE in Korean men were 13.4% (self-reported ED) and 11% (IELT <= 2-min), respectively Risk factors and other socioeconomic and mental health factors were associated with ED Prevalence. Biochemical factors such as HbAtc, triglycerides, testosterone, and DHEA-S were significantly related to ED prevalence.
C1 Univ Ulsan, Coll Med, Asan Med Ctr, Dept Urol, Seoul, South Korea.
   Chonbuk Natl Univ, Sch Med, Chonju, South Korea.
   Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Seoul, South Korea.
   Pusan Natl Univ, Sch Med, Pusan 609735, South Korea.
   Korea Univ, Sch Med, Seoul 136701, South Korea.
   Chonnam Natl Univ, Sch Med, Kwangju, South Korea.
   Ewha Womans Univ, Sch Med, Dept Prevent Med, Seoul, South Korea.
   Gyeongsang Natl Univ, Sch Med, Dept Urol, Jinju, South Korea.
C3 University of Ulsan; Asan Medical Center; Jeonbuk National University;
   Sungkyunkwan University (SKKU); Samsung Medical Center; Pusan National
   University; Pusan National University Hospital; Korea University; Korea
   University Medicine (KU Medicine); Chonnam National University; Ewha
   Womans University; Gyeongsang National University
RP Hyun, JS (corresponding author), Gyeongsang Natl Univ Hosp, Dept Urol, 90 Chilamdong, Jinju 660702, South Korea.
EM hyunjs@gshp.gsnu.ac.kr
RI Park, Haekyun/JWF-7949-2024; Park, Kwangsung/AAQ-7740-2020; Kim,
   Tae/C-1272-2009
OI Park, Kwangsung/0000-0001-8827-162X; Park, Hyesook/0000-0002-9359-6522
CR Ahn TY, 2001, Korean J Urol, V42, P535
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   Teloken P, 2006, J SEX MED, V3, P778, DOI 10.1111/j.1743-6109.2006.00286.x
NR 26
TC 113
Z9 117
U1 0
U2 7
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1743-6095
EI 1743-6109
J9 J SEX MED
JI J. Sex. Med.
PD SEP
PY 2007
VL 4
IS 5
BP 1269
EP 1276
DI 10.1111/j.1743-6109.2007.00554.x
PG 8
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 207KY
UT WOS:000249251200012
PM 17635695
DA 2025-06-11
ER

PT J
AU Dadoniene, J
   Cypiene, A
   Rinkuniene, E
   Badariene, J
   Laucevicius, A
AF Dadoniene, Jolanta
   Cypiene, Alma
   Rinkuniene, Egidija
   Badariene, Jolita
   Laucevicius, Aleksandras
TI Vitamin D, cardiovascular and bone health in postmenopausal women with
   metabolic syndrome
SO ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE
LA English
DT Article
DE metabolic syndrome; vitamin D; bone mineral density; vascular stiffness
ID D DEFICIENCY; ENDOTHELIAL DYSFUNCTION; RISK; SUPPLEMENTATION; PARAMETERS
AB Background. The evidence highlights the importance of improving vitamin D levels in the general population for the prevention of adverse long-term health risks, including cardiovascular events, metabolic syndrome, cancer, anxiety and depression, and overall mortality, although controversies in the research are common.
   Objectives. The purpose of this study was to investigate the relationship between vitamin D and vascular and bone health among postmenopausal metabolic women, controlling for traditional cardiovascular factors, and thus seeking to explore their plausible relation. The secondary aim was to look specifically for the relation between artery stiffness and bone health.
   Material and methods. This is a cross-sectional study designed to evaluate the relation between vitamin D level and vascular and bone health among women with metabolic syndrome. Two hundred and ten women visiting a cardiologist were recruited consecutively into the study. The study variables included clinical examination, laboratory findings, measurements of vascular stiffness, and bone turnover markers.
   Results. We found 126 (60%) metabolic women with a vitamin D deficiency (50 nmol/L) among the study group. We discovered no statistically significant correlation between vitamin D and vascular stiffness. Vitamin D was not associated neither with femoral neck bone mineral density (BMD) and T score, nor with lumbar spine BMD and T score. Nevertheless, there was an indirect weak correlation between vascular stiffness, in particular the augmentation index (AIx), and all bone health markers, including BMD and T score in both the femur head and lumbar spine.
   Conclusions. We showed a high proportion of postmenopausal metabolic women with a vitamin D deficiency, but there was no relation between vitamin D and vascular health or vitamin D and bone health. Nevertheless, the relation between vascular health and bone health exists, although the role of vitamin D in this link has not yet been established.
C1 [Dadoniene, Jolanta] Vilnius Univ, Fac Med, Inst Hlth Sci, Vilnius, Lithuania.
   [Dadoniene, Jolanta; Cypiene, Alma; Rinkuniene, Egidija; Badariene, Jolita; Laucevicius, Aleksandras] State Res Inst Innovat Med, Vilnius, Lithuania.
   [Cypiene, Alma; Rinkuniene, Egidija; Badariene, Jolita; Laucevicius, Aleksandras] Vilnius Univ Hosp, Ctr Cardiol & Angiol, Vilnius, Lithuania.
C3 Vilnius University; State Research Institute Centre for Innovative
   Medicine; Vilnius University Hospital Santariskiu Klinikos
RP Dadoniene, J (corresponding author), Vilnius Univ, Fac Med, Inst Hlth Sci, Vilnius, Lithuania.; Dadoniene, J (corresponding author), State Res Inst Innovat Med, Vilnius, Lithuania.
EM jolanta.dadoniene@mf.vu.lt
OI Cypiene, Alma/0000-0001-5697-3731; Dadoniene,
   Jolanta/0000-0002-4470-4603
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NR 26
TC 8
Z9 8
U1 0
U2 12
PU WROCLAW MEDICAL UNIV
PI WROCLAW
PA UL K MARCINKOWSKIEGO 2-6, WROCLAW, 50-368, POLAND
SN 1899-5276
EI 2451-2680
J9 ADV CLIN EXP MED
JI Adv. Clin. Exp. Med.
PD NOV
PY 2018
VL 27
IS 11
BP 1555
EP 1560
DI 10.17219/acem/75147
PG 6
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA HC5IQ
UT WOS:000451837100013
PM 30058783
OA gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Bica, T
   Castelló, R
   Toussaint, LL
   Montesó-Curto, P
AF Bica, Teodora
   Castello, Ruth
   Toussaint, Loren L.
   Monteso-Curto, Pilar
TI Depression as a Risk Factor of Organic Diseases: An International
   Integrative Review
SO JOURNAL OF NURSING SCHOLARSHIP
LA English
DT Review
DE Depression; disease risk factor; modifiable factors; physical illnesses;
   triggers
ID COGNITIVE IMPAIRMENT; COMORBIDITIES; DISORDERS; SYMPTOMS; DEMENTIA
AB Purpose and Design: This integrative review offers a systematic synthesis of the international literature regarding the role of depression as a risk factor in physical illnesses and the mechanisms of this connection. Special attention is paid to those modifiable factors.
   Findings: Published studies of depression and physical illness and disease (N = 24) from five countries that were indexed in PubMed, the Cumulative Index to Nursing and Allied Health Literature (CINAHL), APA PsycNET, Scopus, Dialnet, and CUIDEN were examined. Results suggest that depression is a significant risk factor for the development of physical illnesses and diseases. More commonly studied were the connections between depression and cardiovascular disease, metabolic syndrome, biochemical alterations, diabetes, dementia, cognitive impairment, Alzheimer's disease, somatization and chronic pain, asthma, arthritis, and hyperlipidemia. Less frequently studied conditions connected to depression were cancer, infections, allergies, autoimmune disease, gastric ulcer, rhinitis, thyroiditis, bronchitis, migraines, fractures, and osteoporosis.
   Conclusions: Mechanisms connecting depression to physical illness appear to involve alterations in the hypothalamic-pituitary axis, unhealthy lifestyle, chronic or acute stressors including posttraumatic stress, an increase in C-reactive protein (CRP) in men, taking antidepressant medication, and social and emotional loneliness.
C1 [Bica, Teodora] Comarcal Mora dEbre Hosp, Mora Debre, Spain.
   [Castello, Ruth] Brighton & Sussex Univ Hosp NHS Trust, Emergency Dept, Brighton, E Sussex, England.
   [Toussaint, Loren L.] Luther Coll, Dept Psychol, Decorah, IA USA.
   [Monteso-Curto, Pilar] Rovira & Virgili Univ, Dept Nursing, Avda Remolins 13-15,Campus Terres de lEbre, Tortosa 43500, Spain.
C3 Brighton and Sussex University Hospitals NHS Trust; University of
   Brighton; Universitat Rovira i Virgili
RP Montesó-Curto, P (corresponding author), Rovira & Virgili Univ, Dept Nursing, Avda Remolins 13-15,Campus Terres de lEbre, Tortosa 43500, Spain.
EM mariapilar.monteso@urv.cat
RI Montesó-Curto, Pilar/I-5875-2019; Monteso-Curto, Pilar/A-6749-2018
OI Monteso-Curto, Pilar/0000-0002-0833-2152
CR Aguilar-Navarro S, 2007, GAC MED MEX, V143, P141
   Aloumanis K, 2013, HORM-INT J ENDOCRINO, V12, P350, DOI 10.1007/BF03401301
   Aragonès E, 2009, ATEN PRIM, V41, P545, DOI 10.1016/j.aprim.2008.11.011
   Borreu-Foguet Q., 2013, ATEN PRIM, V45, P141
   Cahoon CG, 2012, AM J NURS, V112, P22, DOI 10.1097/01.NAJ.0000422251.65212.4b
   Chinchilla-Moren A., 2008, DEPRESSION ITS MASKS
   Chokka P, 2006, J PSYCHIATR NEUROSCI, V31, P414
   Clancy N, 2013, FAM PRACT, V30, P587, DOI 10.1093/fampra/cmt032
   de las Cuevas C, 2011, REV PSIQUIATR SALUD, V4, P119, DOI 10.1016/j.rpsm.2011.02.004
   Drageset J, 2012, J CLIN NURS, V21, P965, DOI 10.1111/j.1365-2702.2011.03932.x
   Drayer RA, 2005, INT J GERIATR PSYCH, V20, P973, DOI 10.1002/gps.1389
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   Monteso M. P., 2009, REV ENFERMERIA, V32, P828
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NR 29
TC 54
Z9 60
U1 1
U2 23
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1527-6546
EI 1547-5069
J9 J NURS SCHOLARSHIP
JI J. Nurs. Scholarsh.
PD JUL
PY 2017
VL 49
IS 4
BP 389
EP 399
DI 10.1111/jnu.12303
PG 11
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA FC8SI
UT WOS:000407110900005
PM 28692781
OA Bronze
DA 2025-06-11
ER

PT J
AU Lee, JW
   Kang, JH
   Lee, KE
   Park, DJ
   Kang, SW
   Kwok, SK
   Kim, SK
   Choe, JY
   Kim, HA
   Sung, YK
   Shin, K
   Lee, SI
   Lee, CH
   Choi, SJ
   Lee, SS
AF Lee, Jeong-Won
   Kang, Ji-Hyoun
   Lee, Kyung-Eun
   Park, Dong-Jin
   Kang, Seong Wook
   Kwok, Seung-Ki
   Kim, Seong-Kyu
   Choe, Jung-Yoon
   Kim, Hyoun-Ah
   Sung, Yoon-Kyoung
   Shin, Kichul
   Lee, Sang-Il
   Lee, Chang Hoon
   Choi, Sung Jae
   Lee, Shin-Seok
TI Effects of risk factors for and components of metabolic syndrome on the
   quality of life of patients with systemic lupus erythematosus: a
   structural equation modeling approach
SO QUALITY OF LIFE RESEARCH
LA English
DT Article
DE Systemic lupus erythematosus; Quality of life; Metabolic syndrome;
   Depression
ID NUTRITION EXAMINATION SURVEY; SOCIOECONOMIC-STATUS; NATIONAL-HEALTH;
   ASSOCIATION; PREVALENCE; DISEASE; OBESITY; IMPACT; ADULTS; WOMEN
AB This study assessed the relationships among the risk factors for and components of metabolic syndrome (MetS) and health-related quality of life (HRQOL) in a hypothesized causal model using structural equation modeling (SEM) in patients with systemic lupus erythematosus (SLE).
   Of the 505 SLE patients enrolled in the Korean Lupus Network (KORNET registry), 244 had sufficient data to assess the components of MetS at enrollment. Education level, monthly income, corticosteroid dose, Systemic Lupus Erythematosus Disease Activity Index, Physicians' Global Assessment, Beck Depression Inventory, MetS components, and the Short Form-36 at the time of cohort entry were determined. SEM was used to test the causal relationship based on the Analysis of Moment Structure.
   The average age of the 244 patients was 40.7 +/- 11.8 years. The SEM results supported the good fit of the model (chi (2) = 71.629, p = 0.078, RMSEA 0.034, CFI 0.972). The final model showed a direct negative effect of higher socioeconomic status and a positive indirect effect of higher disease activity on MetS, the latter through corticosteroid dose. MetS did not directly impact HRQOL but had an indirect negative impact on it, through depression.
   In our causal model, MetS risk factors were related to MetS components. The latter had a negative indirect impact on HRQOL, through depression. Clinicians should consider socioeconomic status and medication and seek to modify disease activity, MetS, and depression to improve the HRQOL of SLE patients.
C1 [Lee, Jeong-Won; Kang, Ji-Hyoun; Lee, Kyung-Eun; Park, Dong-Jin; Lee, Shin-Seok] Chonnam Natl Univ Med Sch & Hosp, Dept Rheumatol, 42 Jebong Ro, Kwangju 61469, South Korea.
   [Kang, Seong Wook] Chungnam Natl Univ, Sch Med, Dept Internal Med, Taejon, South Korea.
   [Kwok, Seung-Ki] Catholic Univ Korea, Coll Med, Seoul St Marys Hosp, Div Rheumatol,Dept Internal Med, Seoul, South Korea.
   [Kim, Seong-Kyu; Choe, Jung-Yoon] Catholic Univ Daegu, Sch Med, Dept Internal Med, Taegu, South Korea.
   [Kim, Hyoun-Ah] Ajou Univ, Sch Med, Ajou Univ Hosp, Dept Rheumatol, Suwon, South Korea.
   [Sung, Yoon-Kyoung] Hanyang Univ, Hosp Rheumat Dis, Dept Rheumatol, Seoul, South Korea.
   [Shin, Kichul] Seoul Natl Univ, Boramae Med Ctr, Metropolitan Govt, Dept Internal Med, Seoul, South Korea.
   [Lee, Sang-Il] Gyeongsang Natl Univ, Sch Med, Dept Internal Med, Jinju, Gyeongnam, South Korea.
   [Lee, Sang-Il] Gyeongsang Natl Univ, Sch Med, Inst Hlth Sci, Jinju, Gyeongnam, South Korea.
   [Lee, Chang Hoon] Wonkwang Univ, Sch Med, Dept Internal Med, Div Rheumatol, Iksan, South Korea.
   [Choi, Sung Jae] Korea Univ, Ansan Hosp, Dept Internal Med, Div Rheumatol, Ansan, South Korea.
C3 Chonnam National University; Chonnam National University Hospital;
   Chungnam National University; Seoul St. Mary's Hospital; Catholic
   University of Korea; Catholic University of Daegu; Ajou University; Ajou
   University Hospital; Hanyang University; Seoul National University
   (SNU); Seoul National University Hospital; Gyeongsang National
   University; Gyeongsang National University; Wonkwang University; Korea
   University; Korea University Medicine (KU Medicine)
RP Lee, SS (corresponding author), Chonnam Natl Univ Med Sch & Hosp, Dept Rheumatol, 42 Jebong Ro, Kwangju 61469, South Korea.
EM shinseok@chonnam.ac.kr
RI Lee, Shin-Seok/AAC-6779-2021; Kim, Yun Hak/ABF-3331-2021; Jung,
   SeungHyun/HTS-1049-2023
OI Kang, Seong Wook/0000-0002-0076-0822; Kang, Ji-Hyoun/0000-0003-1113-2001
FU Research Program - Korea Centers for Disease Control and Prevention
   [2014-E63002-00]
FX This work was supported by the Research Program funded by the Korea
   Centers for Disease Control and Prevention (2014-E63002-00).
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NR 44
TC 10
Z9 11
U1 1
U2 9
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0962-9343
EI 1573-2649
J9 QUAL LIFE RES
JI Qual. Life Res.
PD JAN
PY 2018
VL 27
IS 1
BP 105
EP 113
DI 10.1007/s11136-017-1689-z
PG 9
WC Health Care Sciences & Services; Health Policy & Services; Public,
   Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services; Public, Environmental & Occupational
   Health
GA FT0EI
UT WOS:000422793600011
PM 28831690
DA 2025-06-11
ER

PT J
AU Goldfarb, M
   De Hert, M
   Detraux, J
   Di Palo, K
   Munir, H
   Music, S
   Piña, I
   Ringen, PA
AF Goldfarb, Michael
   De Hert, Marc
   Detraux, Johan
   Di Palo, Katherine
   Munir, Haroon
   Music, Sanela
   Pina, Ileana
   Ringen, Petter Andreas
TI Severe Mental Illness and Cardiovascular Disease JACC
   State-of-the-Art Review
SO JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
LA English
DT Review
DE cardio-metabolic; cardiovascular disease; mental illness; risk factors
ID CORONARY-HEART-DISEASE; ACUTE MYOCARDIAL-INFARCTION; MAJOR DEPRESSIVE
   DISORDER; LIFE-STYLE INTERVENTION; RANDOMIZED CONTROLLED-TRIAL;
   PLACEBO-CONTROLLED TRIAL; BIPOLAR DISORDER; RISK-FACTORS;
   SMOKING-CESSATION; METABOLIC SYNDROME
AB People with severe mental illness, consisting of schizophrenia, bipolar disorder, and major depression, have a high burden of modifiable cardiovascular risk behaviors and conditions and have a cardiovascular mortality rate twice that of the general population. People with acute and chronic cardiovascular disease are at a higher risk of developing mental health symptoms and disease. There is emerging evidence for shared etiological factors between severe mental illness and cardiovascular disease that includes biological, genetic, and behavioral mechanisms. This state-of-the art review will describe the relationship between severe mental illness and cardiovascular disease, explore the factors that lead to poor cardiovascular outcomes in people with severe mental illness, propose strategies to improve the cardiovascular health of people with severe mental illness, and present areas for future research focus. (J Am Coll Cardiol 2022;80:918-933)(c) 2022 by the American College of Cardiology Foundation.
C1 [Goldfarb, Michael] McGill Univ, Jewish Gen Hosp, Div Cardiol, 3755 Cote Ste Catherine Rd,Off E-212, Montreal, PQ H3T 1E2, Canada.
   [De Hert, Marc; Detraux, Johan] Katholieke Univ, Univ Psychiat Ctr, Kortenberg, Belgium.
   [De Hert, Marc] Katholieke Univ Leuven, Ctr Clin Psychiat, Dept Neurosci, Leuven, Belgium.
   [De Hert, Marc] Katholieke Univ Leuven, Leuven Brain Inst, Leuven, Belgium.
   [De Hert, Marc] Univ Antwerp, Antwerp Hlth Law & Eth Chair, Antwerp, Belgium.
   [Di Palo, Katherine] Albert Einstein Coll Med, Bronx, NY 10467 USA.
   [Di Palo, Katherine] Montefiore Med Ctr, 111 E 210th St, Bronx, NY 10467 USA.
   [Munir, Haroon; Music, Sanela] McGill Univ, Fac Med & Hlth Sci, Montreal, PQ, Canada.
   [Pina, Ileana] Thomas Jefferson Univ, Sidney Kimmel Med Coll, Philadelphia, PA 19107 USA.
   [Ringen, Petter Andreas] Oslo Univ Hosp, Div Mental Hlth & Addict, Oslo, Norway.
C3 McGill University; Jewish General Hospital - Montreal; KU Leuven; KU
   Leuven; KU Leuven; University of Antwerp; Yeshiva University; Montefiore
   Medical Center; Albert Einstein College of Medicine; Montefiore Medical
   Center; Albert Einstein College of Medicine; McGill University; Thomas
   Jefferson University; University of Oslo
RP Goldfarb, M (corresponding author), McGill Univ, Jewish Gen Hosp, Div Cardiol, 3755 Cote Ste Catherine Rd,Off E-212, Montreal, PQ H3T 1E2, Canada.
EM michael.j.goldfarb@mcgill.ca
RI Goldfarb, Michael/AAY-2362-2021; ringen, petter/C-5036-2011; De Hert,
   Marc/AAH-6090-2021; DiPalo, Katherine/HNP-2444-2023
OI Music, Sanela/0000-0002-6788-5603; De Hert, Marc/0000-0003-4255-5920;
   Pina, Ileana/0000-0002-4986-7129; Di Palo, Katherine/0000-0003-1558-4718
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NR 112
TC 85
Z9 88
U1 9
U2 24
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0735-1097
EI 1558-3597
J9 J AM COLL CARDIOL
JI J. Am. Coll. Cardiol.
PD AUG 30
PY 2022
VL 80
IS 9
BP 918
EP 933
DI 10.1016/j.jacc.2022.06.017
EA AUG 2022
PG 16
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 4X7RA
UT WOS:000861033600009
PM 36007991
OA Bronze
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Smith, TW
   Eagle, DE
   Proeschold-Bell, RJ
AF Smith, Timothy W.
   Eagle, David E.
   Proeschold-Bell, Rae Jean
TI Prospective Associations Between Depressive Symptoms and the Metabolic
   Syndrome: the Spirited Life Study of Methodist Pastors in North Carolina
SO ANNALS OF BEHAVIORAL MEDICINE
LA English
DT Article
DE Metabolic syndrome; Depression; Prospective studies
ID CARDIOVASCULAR RISK; SEX-DIFFERENCES; HIGH-RATES; METAANALYSIS;
   VARIABLES; INTERVENTION; EXERCISE; OBESITY; STROKE; HEALTH
AB Metabolic syndrome (Met-S) has a robust concurrent association with depression. A small, methodologically limited literature suggests that Met-S and depression are reciprocally related over time, an association that could contribute to their overlapping influences on morbidity and mortality in cardiovascular disease, diabetes, and cancer.
   Using a refined approach to the measurement of Met-S as a continuous latent variable comprising continuous components, this study tested the prospective associations between Met-S and depression.
   This study of 1114 clergy included four annual assessments of depressive symptoms and Met-S components. Standard methods were used to measure Met-S risk factors, and the Patient Health Questionnaire-8 was used to assess depressive symptoms. We used confirmatory factor analysis to verify the structure of Met-S and depression and structural equation modeling to quantify the prospective relationships.
   The statistical models confirmed the validity of quantifying Met-S as a continuous latent variable, replicated previous evidence of a concurrent association, and indicated a significant prospective association of initial depressive symptoms with subsequent Met-S. Initial Met-S was at most only weakly associated with subsequent depressive symptoms, and the former prospective effect was significantly larger. Associations of depressive symptoms and Met-S were significant for both men and women, but somewhat stronger among men.
   Results support representation of Met-S as a continuous latent variable. The association of initial depressive symptoms with later Met-S suggests that interventions addressing these correlated risk factors may prove useful in preventive efforts.
C1 [Smith, Timothy W.] Univ Utah, Dept Psychol, Salt Lake City, UT 84112 USA.
   [Eagle, David E.; Proeschold-Bell, Rae Jean] Duke Univ, Ctr Hlth Policy & Inequal Res, POB 90392, Durham, NC 27710 USA.
   [Proeschold-Bell, Rae Jean] Duke Univ, Duke Global Hlth Inst, Durham, NC USA.
C3 Utah System of Higher Education; University of Utah; Duke University;
   Duke University
RP Eagle, DE (corresponding author), Duke Univ, Ctr Hlth Policy & Inequal Res, POB 90392, Durham, NC 27710 USA.
EM tim.smith@psych.utah.edu; david.eagle@duke.edu; rae.jean@duke.edu
RI Eagle, David/AAG-9344-2021
FU Rural Church Area of The Duke Endowment
FX This study was funded by a grant from the Rural Church Area of The Duke
   Endowment. The Duke Endowment had no control over the design and conduct
   of the study; collection, management, analysis, and interpretation of
   the data; and preparation, review, or approval of the manuscript.
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NR 40
TC 6
Z9 6
U1 0
U2 4
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0883-6612
EI 1532-4796
J9 ANN BEHAV MED
JI Ann. Behav. Med.
PD AUG
PY 2017
VL 51
IS 4
BP 610
EP 619
DI 10.1007/s12160-017-9883-3
PG 10
WC Psychology, Multidisciplinary
WE Social Science Citation Index (SSCI)
SC Psychology
GA FF1YF
UT WOS:000408694400013
PM 28210925
DA 2025-06-11
ER

PT J
AU Bilu, C
   Einat, H
   Zimmet, P
   Kronfeld-Schor, N
AF Bilu, Carmel
   Einat, Haim
   Zimmet, Paul
   Kronfeld-Schor, Noga
TI Circadian rhythms-related disorders in diurnal fat sand rats under
   modern lifestyle conditions: A review
SO FRONTIERS IN PHYSIOLOGY
LA English
DT Review
DE circadian desynchrony; circadian rhythms; fat sand rats; diurnality;
   diabetes; depression
ID SEASONAL AFFECTIVE-DISORDER; ANXIETY-LIKE BEHAVIORS; P75 NEUROTROPHIN
   RECEPTOR; BRIGHT LIGHT TREATMENT; PSAMMOMYS-OBESUS; SUPRACHIASMATIC
   NUCLEUS; INSULIN-RESISTANCE; METABOLIC SYNDROME; DIABETES-MELLITUS;
   SLEEP DISTURBANCES
AB Modern lifestyle reduces environmental rhythmicity and may lead to circadian desynchrony. We are exposed to poor day-time lighting indoors and excessive night-time artificial light. We use air-conditioning to reduce ambient temperature cycle, and food is regularly available at all times. These disruptions of daily rhythms may lead to type 2 diabetes mellitus (T2DM), obesity, cardiometabolic diseases (CMD), depression and anxiety, all of which impose major public health and economic burden on societies. Therefore, we need appropriate animal models to gain a better understanding of their etiologic mechanisms, prevention, and management.We argue that the fat sand rat (Psammomys obesus), a diurnal animal model, is most suitable for studying the effects of modern-life conditions. Numerous attributes make it an excellent model to study human health disorders including T2DM, CMD, depression and anxiety. Here we review a comprehensive series of studies we and others conducted, utilizing the fat sand rat to study the underlying interactions between biological rhythms and health. Understanding these interactions will help deciphering the biological basis of these diseases, which often occur concurrently. We found that when kept in the laboratory (compared with natural and semi-wild outdoors conditions where they are diurnal), fat sand rats show low amplitude, nocturnal or arrhythmic activity patterns, dampened daily glucose rhythm, glucose intolerance, obesity and decreased survival rates. Short photoperiod acclimation exacerbates these pathologies and further dampens behavioral and molecular daily rhythms, resulting in CMD, T2DM, obesity, adipocyte dysfunction, cataracts, depression and anxiety. Increasing environmental rhythmicity by morning bright light exposure or by access to running wheels strengthens daily rhythms, and results in higher peak-to-trough difference in activity, better rhythmicity in clock genes expression, lower blood glucose and insulin levels, improved glucose tolerance, lower body and heart weight, and lower anxiety and depression. In summary, we have demonstrated that fat sand rats living under the correspondent of "human modern lifestyle " conditions exhibit dampened behavioral and biological rhythms and develop circadian desynchrony, which leads to what we have named "The Circadian Syndrome ". Environmental manipulations that increase rhythmicity result in improvement or prevention of these pathologies. Similar interventions in human subjects could have the same positive results and further research on this should be undertaken.
C1 [Bilu, Carmel; Kronfeld-Schor, Noga] Tel Aviv Univ, Sch Zool, Tel Aviv, Israel.
   [Einat, Haim] Tel Aviv Yaffo Acad Coll, Sch Behav Sci, Tel Aviv, Israel.
   [Zimmet, Paul] Monash Univ, Dept Diabet, Melbourne, Vic, Australia.
C3 Tel Aviv University; Monash University
RP Bilu, C (corresponding author), Tel Aviv Univ, Sch Zool, Tel Aviv, Israel.
EM carmel.bilu@gmail.com
RI Kronfeld-Schor, Noga/AAU-3792-2020; Zimmet, Paul/H-7635-2013
OI Kronfeld-Schor, Noga/0000-0002-5224-3341
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NR 210
TC 5
Z9 5
U1 0
U2 16
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1664-042X
J9 FRONT PHYSIOL
JI Front. Physiol.
PD SEP 7
PY 2022
VL 13
AR 963449
DI 10.3389/fphys.2022.963449
PG 16
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA 4R1IK
UT WOS:000856523800001
PM 36160856
OA gold, Green Published
DA 2025-06-11
ER

PT S
AU Bachar, SC
   Bachar, R
   Jannat, K
   Jahan, R
   Rahmatullah, M
AF Bachar, Sitesh C.
   Bachar, Ritesh
   Jannat, Khoshnur
   Jahan, Rownak
   Rahmatullah, Mohammed
BE Sarker, SD
   Nahar, L
TI Hepatoprotective natural products
SO MEDICINAL NATURAL PRODUCTS: A DISEASE-FOCUSED APPROACH
SE Annual Reports in Medicinal Chemistry
LA English
DT Review; Book Chapter
ID NONALCOHOLIC FATTY LIVER; ARATICUM ANNONA-CRASSIFLORA;
   CARBON-TETRACHLORIDE; INDUCED HEPATOTOXICITY; OXIDATIVE STRESS;
   BIOACTIVE COMPOUNDS; PHYLLANTHUS-NIRURI; METABOLIC SYNDROME; HERBAL
   MEDICINES; METHANOL EXTRACT
C1 [Bachar, Sitesh C.] Univ Dhaka, Fac Pharm, Dept Pharm, Dhaka, Bangladesh.
   [Bachar, Ritesh] Univ Informat Technol & Sci, Dept Pharm, Dhaka, Bangladesh.
   [Jannat, Khoshnur; Jahan, Rownak; Rahmatullah, Mohammed] Univ Dev Alternat, Dept Biotechnol & Genet Engn, Dhaka, Bangladesh.
C3 University of Dhaka
RP Bachar, SC (corresponding author), Univ Dhaka, Fac Pharm, Dept Pharm, Dhaka, Bangladesh.
EM bacharsc@du.ac.bd
RI Bachar, Sitesh/AFL-6003-2022
OI Bachar, Ritesh/0009-0006-5930-0480
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NR 159
TC 10
Z9 11
U1 0
U2 13
PU ACADEMIC PRESS LTD-ELSEVIER SCIENCE LTD
PI LONDON
PA 125 LONDON WALL, LONDON EC2Y 5AS, ENGLAND
SN 0065-7743
BN 978-0-12-821019-2
J9 ANNU REP MED CHEM
JI Annu. Rep. Med. Chem.
PY 2020
VL 55
BP 207
EP 249
DI 10.1016/bs.armc.2020.06.003
PG 43
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Book Citation Index – Science (BKCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA BQ6IG
UT WOS:000611827900008
DA 2025-06-11
ER

PT J
AU Brown, ES
   Varghese, FP
   McEwen, BS
AF Brown, ES
   Varghese, FP
   McEwen, BS
TI Association of depression with medical illness: Does cortisol play a
   role?
SO BIOLOGICAL PSYCHIATRY
LA English
DT Review
DE depression; hippocampus; waist-to-hip ratio; osteoporosis; Cushing's
   syndrome; metabolic syndrome
ID BONE-MINERAL DENSITY; DEXAMETHASONE-SUPPRESSION TEST;
   CORTICOTROPIN-RELEASING HORMONE; PITUITARY-ADRENAL AXIS; URINARY-FREE
   CORTISOL; INCREASED CARDIOVASCULAR RISK; INCREASED INTRAABDOMINAL FAT;
   CHRONIC UNIPOLAR DEPRESSION; MIDDLE-AGED MEN; MAJOR DEPRESSION
AB Elevated cortisol in a subset of depressed patients is an enduring and well-replicated finding. Much interest has focused on the possible effects of depression on the hippocampus; however, an emerging body of evidence suggests an association between depression and non-central nervous system illnesses, In this review, data on the effects of depression on the brain and other organ systems sensitive to elevated cortisol are discussed. From searches of the MEDLINE, PSYCHINFO, and Current Contents databases, and other sources, articles were found specifically related to depression and physical changes or medical conditions associated with corticosteroid excess in patients with Cushing's disease, including cognitive impairment, hippocampal atrophy, increased waist-to-hip ratio, bone loss, hypertension, diabetes, peptic ulcers, and hyperlipidemia. Data are strongest for a relationship between elevated cortisol and depression, hippocampal atrophy, cognitive impairment, abdominal obesity, and loss of bone density. Some evidence suggests an association between depression and hypertension, peptic ulcers, and diabetes. Depression does not appear to be associated with hyperlipidemia. The data provide some support for similar health effects in depressed patients and patients with Cushing's disease or the metabolic syndrome; however, additional studies are needed relating systemic effects of depression to cortisol. Limitations of the current literature, treatment implications, and possible directions for future research are discussed. (C) 2004 Society of Biological Psychiatry.
C1 Univ Texas, SW Med Ctr, Dept Psychiat, Psychoneuroendocrine Res Program, Dallas, TX 75390 USA.
   Rockefeller Univ, Howard & Margaret Milliken Lab Neuroendocrinol, New York, NY 10021 USA.
C3 University of Texas System; University of Texas Southwestern Medical
   Center Dallas; University of Texas Dallas; Rockefeller University
RP Brown, ES (corresponding author), Univ Texas, SW Med Ctr, Dept Psychiat, Psychoneuroendocrine Res Program, 5323 Harry Hines Blvd, Dallas, TX 75390 USA.
RI McEwen, Bruce/Z-1630-2019
FU NIMH NIH HHS [MH 58911, MH 01725] Funding Source: Medline
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NR 126
TC 421
Z9 513
U1 2
U2 54
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD JAN 1
PY 2004
VL 55
IS 1
BP 1
EP 9
DI 10.1016/S0006-3223(03)00473-6
PG 9
WC Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Psychiatry
GA 759NH
UT WOS:000187743400001
PM 14706419
DA 2025-06-11
ER

PT J
AU Misra, A
   Ganda, OP
AF Misra, Anoop
   Ganda, Om P.
TI Migration and its impact on adiposity and type 2 diabetes
SO NUTRITION
LA English
DT Review
DE migration; type 2 diabetes; obesity; physical activity; nutrition;
   ethnicity
ID CORONARY-HEART-DISEASE; INSULIN-RESISTANCE-SYNDROME; IMPAIRED
   GLUCOSE-TOLERANCE; ASIAN INDIAN ADOLESCENTS; TOKELAU-ISLAND MIGRANT;
   BODY-FAT DISTRIBUTION; RISK-FACTORS; METABOLIC SYNDROME; UNITED-STATES;
   JAPANESE-AMERICANS
AB In this review, we discuss the impact of migration on the incidence and prevalence of obesity and type 2 diabetes mellitus (T2DM) in different ethnic groups and populations. We also analyze the determinants of such phenomena in view of the global increase in the migration and escalating prevalence of obesity and T2DM. The risk escalation of the obesity and T2DM followed a gradient, as migrants (Blacks, Hispanics, Chinese, South Asians, etc.) became more affluent and urbanized, indicating an important role of environmental factors. A stepwise increase in the prevalence of obesity in Blacks along the path of migration (5% in Nigeria, 23% in Jamaica, and 39% in the United States) is a classic example. Furthermore, South Asian migrants, who are particularly predisposed to develop insulin resistance and T2DM, showed nearly four times prevalence rates of T2DM than rural sedentee populations. Similar observations were also reported in intracountry migrants and resettled indigenous populations. The determinants were found to include nutrition transition, physical inactivity, gene-environment interaction, stress, and other factors such as ethnic susceptibility. However, certain contradictory trends were also seen in some migrant communities and have been explained by various phenomena such as healthy migrant effect, "salmon bias", and adherence to traditional diets. A review of the evidence suggests a critical role of environmental factors in conferring an increased risk of obesity and T2DM. The important contributory factors to this phenomenon were urbanization, mechanization, and changes in nutrition and lifestyle behaviors, but the role of stress and asyet unknown factors remain to be determined. (c) 2007 Elsevier Inc. All rights reserved.
C1 Fortis Hosp, Dept Diabet & Metab Dis, New Delhi, India.
   Joslin Diabet Ctr, Boston, MA 02215 USA.
C3 Harvard University; Harvard University Medical Affiliates; Joslin
   Diabetes Center, Inc.
RP Misra, A (corresponding author), Fortis Hosp, Dept Diabet & Metab Dis, New Delhi, India.
EM anoopmisra@metabolicresearchindia.com
FU NHLBI NIH HHS [HL73168-02] Funding Source: Medline; NIDDK NIH HHS [DK
   60115-02] Funding Source: Medline
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NR 119
TC 201
Z9 235
U1 0
U2 53
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0899-9007
EI 1873-1244
J9 NUTRITION
JI Nutrition
PD SEP
PY 2007
VL 23
IS 9
BP 696
EP 708
DI 10.1016/j.nut.2007.06.008
PG 13
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nutrition & Dietetics
GA 198ZT
UT WOS:000248666700010
PM 17679049
DA 2025-06-11
ER

PT J
AU Bernhardsen, GP
   Thomas, O
   Mäntyselkä, P
   Niskanen, L
   Vanhala, M
   Koponen, H
   Lehto, SM
AF Bernhardsen, Guro Pauck
   Thomas, Owen
   Mantyselka, Pekka
   Niskanen, Leo
   Vanhala, Mauno
   Koponen, Hannu
   Lehto, Soili M.
TI Metabolites and depressive symptoms: Network- and longitudinal analyses
   from the Finnish Depression and Metabolic Syndrome in Adults (FDMSA)
   Study
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Depressive symptoms; Metabolomics; Metabolic markers; Network analysis;
   Longitudinal study
ID MAGNETIC-RESONANCE METABOLOMICS; PROSPECTIVE ASSOCIATIONS; METAANALYSIS;
   SELECTION; DISEASE; GLYCA; RISK; REGULARIZATION; EPIDEMIOLOGY; DISORDERS
AB Background: Depression is associated with metabolic abnormalities linked to metabolic syndrome and tissue inflammation, but the interplay between metabolic markers and their association with subsequent depression is unknown. Therefore, we aimed to describe the network of metabolites and their prospective association with depressive symptoms.Methods: The Finnish Depression and Metabolic Syndrome in Adults (FDMSA) cohort, originally a prospective case-control study, comprised a group with Beck Depression Inventory (BDI)-I scores >= 10 at baseline, and controls (n = 319, BDI-I < 10); mean (sd) follow-up time: 7.4 (0.7) years. Serum metabolic biomarkers were determined by proton nuclear magnetic resonance (NMR), and depressive symptoms sum-score by using the BDII. We examined the prospective associations between metabolites at baseline and BDI score at follow-up utilizing multivariate linear regression, parsimonious predictions models and network analysis.Results: Some metabolites tended to be either negatively (e.g. histidine) or positively associated (e.g. glycoprotein acetylation, creatinine and triglycerides in very large high density lipoproteins [XL-HDL-TG]) with depressive symptoms. None of the associations were significant after correction for multiple testing. The network analysis suggested high correlation among the metabolites, but that none of the metabolites directly influenced subsequent depressive symptoms.Limitations: Although the sample size may be considered satisfactory in a prospective context, we cannot exclude the possibility that our study was underpowered.Conclusions: Our results suggest that the investigated metabolic biomarkers are not a driving force in the development of depressive symptoms. These findings should be confirmed in studies with larger samples and studies that account for the heterogeneity of depressive disorders.
C1 [Bernhardsen, Guro Pauck; Lehto, Soili M.] Akershus Univ Hosp, Dept Res & Dev, Div Mental Hlth Serv, Lorenskog, Norway.
   [Thomas, Owen] Akershus Univ Hosp, Div Res & Innovat, Lorenskog, Norway.
   [Mantyselka, Pekka; Niskanen, Leo; Vanhala, Mauno] Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Gen Practice, Kuopio, Finland.
   [Mantyselka, Pekka] Kuopio Univ Hosp, Clin Res & Trials Ctr, Wellbeing Serv Cty North Savo, Kuopio, Finland.
   [Niskanen, Leo] Paijat Hame Cent Hosp, Dept Internal Med, Endocrinol Diabetol, Lahti, Finland.
   [Niskanen, Leo] Eira Med Ctr & Hosp, Helsinki, Finland.
   [Koponen, Hannu] Univ Helsinki, Psychiat, Helsinki, Finland.
   [Koponen, Hannu] Helsinki Univ Hosp, Helsinki, Finland.
   [Lehto, Soili M.] Univ Oslo, Inst Clin Med, Oslo, Norway.
   [Lehto, Soili M.] Univ Helsinki, Dept Psychiat, Helsinki, Finland.
   [Bernhardsen, Guro Pauck] Akershus Univ Hosp, HF V Guro Pauck Bernhardsen,Postboks 1000, N-1478 Lorenskog, Norway.
C3 University of Oslo; University of Oslo; University of Eastern Finland;
   University of Eastern Finland; University of Eastern Finland Hospital;
   Kuopio University Hospital; Paijat Hame Central Hospital; University of
   Helsinki; University of Helsinki; Helsinki University Central Hospital;
   University of Oslo; University of Helsinki; University of Oslo
RP Bernhardsen, GP (corresponding author), Akershus Univ Hosp, HF V Guro Pauck Bernhardsen,Postboks 1000, N-1478 Lorenskog, Norway.
EM guro.pauck.bernhardsen@ahus.no
RI Bernhardsen, Guro/LTE-1075-2024
OI Lehto, Soili/0000-0003-4324-6679; Koponen, Hannu/0000-0002-7368-1869
FU Central Finland Hospital District; Northern Savo Hospital District;
   Kuopio University Hospital
FX The FDMSA study was supported by the Central Finland Hospital District,
   the Northern Savo Hospital District and the State Research Funding
   through Kuopio University Hospital. The funding source was not involved
   in the study design, data collection, and analysis, inter- pretation of
   the data, writing the manuscript or in the decision to submit the
   manuscript for publication.
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NR 60
TC 1
Z9 1
U1 2
U2 2
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD FEB 15
PY 2024
VL 347
BP 199
EP 209
DI 10.1016/j.jad.2023.11.070
EA NOV 2023
PG 11
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA CQ5O8
UT WOS:001126725000001
PM 38000471
OA hybrid
DA 2025-06-11
ER

PT J
AU Yiaslas, TA
   Rogers-Soeder, TS
   Ono, G
   Kitazono, RE
   Sood, A
AF Yiaslas, Themis A.
   Rogers-Soeder, Tara S.
   Ono, Gregory
   Kitazono, Rachel E.
   Sood, Ajay
TI Effect of a 15-Week Whole Foods, Plant-Based Diet, Physical Activity,
   and Stress Management Intervention on Cardiometabolic Risk Factors in a
   Population of US Veterans: A Retrospective Analysis
SO AMERICAN JOURNAL OF LIFESTYLE MEDICINE
LA English
DT Article; Early Access
DE cardiovascular risk reduction; military veterans; multiple health
   behavior change intervention; plant-based diet; lifestyle medicine
ID CORONARY-HEART-DISEASE; LIFE-STYLE CHANGES; QUALITY-OF-LIFE; RANDOMIZED
   CLINICAL-TRIAL; FAT VEGAN DIET; CARDIAC REHABILITATION; CARDIOVASCULAR
   RISK; ARTERY-DISEASE; UNITED-STATES; PSYCHOSOCIAL STRESS
AB Military Veterans have a higher risk of incident atherosclerotic cardiovascular disease (ASCVD) than the general population and are often clinically complex. We studied the changes in cardiovascular risk factors with a lifestyle intervention in this population. We retrospectively analyzed data from 67 participants (mean age 69.2 (SD 7.9) years; 97% male) with atherosclerotic heart disease and/or type 2 diabetes in a 15-week, multiple health behavior change (MHBC) intervention implemented in a Veterans Affairs (VA) Behavioral Medicine Clinic. The intervention promoted a whole foods, plant-based (WFPB) diet, physical activity, and cognitive-behavioral stress management. We assessed cardiometabolic risk factors at baseline, 1 month into the intervention, and at 15 weeks (post-treatment). Among intervention completers (n = 67), we observed statistically significant improvements in waist circumference (-2.8 inches, P = .03), systolic blood pressure (-7.9 mmHg, P = .03), LDL cholesterol (-11.27 mg/dL, P = .04), fasting glucose (-15.10 mg/dL, P = .03), and hemoglobin A1c (-0.55%, P = .017) at post-treatment. Participants with type 2 diabetes (n = 34) achieved improvements in hemoglobin A1c (-0.80%, P = .007), systolic blood pressure (-10.98 mmHg, P = .01), and diastolic blood pressure (-6.65 mmHg, P = .03) at post-treatment. Medication usage did not significantly change. Veterans who completed the MHBC intervention achieved significant improvements in cardiometabolic risk in a routine VA clinical practice setting.
C1 [Yiaslas, Themis A.] VA Northern Calif Hlth Care Syst, Behav Med Clin, 10535 Hosp Way,Bldg 651, Mather, CA 95655 USA.
   [Yiaslas, Themis A.] UC Davis Sch Med, Dept Internal Med, Div Cardiovasc Med, Sacramento, CA USA.
   [Yiaslas, Themis A.] UC Davis Sch Med, Dept Psychiat & Behav Sci, Sacramento, CA USA.
   [Rogers-Soeder, Tara S.] VA Northern Calif Hlth Care Syst, Nutr & Food Serv, Mather, CA USA.
   [Ono, Gregory] VA Northern Calif Hlth Care Syst, Pharm Serv, Mather, CA USA.
   [Kitazono, Rachel E.] Kaiser Permanente South Sacramento Med Ctr, Behav Med Serv, Sacramento, CA USA.
   [Sood, Ajay] VA Northern Calif Hlth Care Syst, Med Serv, Endocrine Sect, Mather, CA USA.
   [Sood, Ajay] Univ Calif Sacramento, Davis Med Ctr, Dept Internal Med, Div Endocrinol Diabet & Metab, Sacramento, CA USA.
C3 University of California System; University of California Davis;
   University of California System; University of California Davis; Kaiser
   Permanente; California State University System; California State
   University Sacramento
RP Yiaslas, TA (corresponding author), VA Northern Calif Hlth Care Syst, Behav Med Clin, 10535 Hosp Way,Bldg 651, Mather, CA 95655 USA.
EM Themis.Yiaslas@va.gov
OI Yiaslas, Themis/0000-0003-3858-2598
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NR 89
TC 0
Z9 0
U1 2
U2 3
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1559-8276
EI 1559-8284
J9 AM J LIFESTYLE MED
JI Am. J. Lifestyle Med.
PD 2024 AUG 2
PY 2024
DI 10.1177/15598276241267932
EA AUG 2024
PG 18
WC Public, Environmental & Occupational Health
WE Emerging Sources Citation Index (ESCI)
SC Public, Environmental & Occupational Health
GA A8G3I
UT WOS:001284863000001
PM 39554941
OA Green Published
DA 2025-06-11
ER

PT J
AU Rojas, P
   Villar, M
   Gonzalez, A
   Poblete, C
   Funez, F
   Tong, A
   Liberman, C
AF Rojas, Paula
   Villar, Maria
   Gonzalez, Alfonso
   Poblete, Catalina
   Funez, Flora
   Tong, Ana
   Liberman, Claudio
TI Increase in C-reactive protein and lipids in adolescents with
   psychiatric disease
SO PSYCHIATRY RESEARCH
LA English
DT Article
DE Psychosis; C-reactive protein; Inflammation; Adolescence; Metabolic
   syndrome
ID METABOLIC SYNDROME; SERUM-LEVELS; CHILDREN; SCHIZOPHRENIA;
   PSYCHOPATHOLOGY; INTERLEUKIN-6; METAANALYSIS; ASSOCIATION; CHOLESTEROL;
   DEPRESSION
AB Eighteen adolescent patients with severe psychiatric disorders were compared with healthy, eutrophics adolescents for the presence of inflammation and cardiovascular risk factors. We found significant differences in high-sensitivity C-reactive protein, total cholesterol, and triglycerides. Our results show, evidence of an inflammatory status and a deleterious lipid profile, in a very early state of psychiatric disease. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
C1 [Rojas, Paula; Liberman, Claudio] Univ Chile, Clin Hosp, Dept Endocrinol, Santiago, Chile.
   [Villar, Maria] Univ Chile, Clin Hosp, Dept Psychiat, Santiago, Chile.
   [Tong, Ana] Univ Chile, Clin Hosp, Clin Lab, Santiago, Chile.
   [Gonzalez, Alfonso] Psychiat Inst Dr Jose Horwitz, Santiago, Chile.
   [Poblete, Catalina; Funez, Flora] Roberto del Rio Hosp, Dept Psychiat, Santiago, Chile.
C3 Universidad de Chile; Universidad de Chile; Universidad de Chile
RP Rojas, P (corresponding author), San Carlos de Apoquindo 746, Santiago 7610507, Chile.
EM projas@redclinicauchile.cl; cotevillar@gmail.com; aagonzav@uc.cl;
   doctorapoblete@gmail.com; flora@vtr.net; atong@redclinicauchile.cl;
   cliberma@redclinicauchile.cl
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NR 23
TC 4
Z9 4
U1 0
U2 11
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0165-1781
J9 PSYCHIAT RES
JI Psychiatry Res.
PD DEC 30
PY 2011
VL 190
IS 2-3
BP 372
EP 374
DI 10.1016/j.psychres.2011.05.023
PG 3
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 871FI
UT WOS:000298722900038
PM 21684015
DA 2025-06-11
ER

PT J
AU Ng-Mak, D
   Rajagopalan, K
AF Ng-Mak, Daisy
   Rajagopalan, Krithika
TI Examining quality of care for individuals treated for mental health
   using the HEDIS mental health quality measures
SO CURRENT MEDICAL RESEARCH AND OPINION
LA English
DT Article
DE Healthcare quality assessment; Mental health services; Schizophrenia;
   Bipolar disorder; Serious mental illness
ID BIPOLAR DISORDER; METABOLIC SYNDROME; ANTIPSYCHOTIC MEDICATION;
   CONFIDENCE-INTERVALS; SCHIZOPHRENIA; ADHERENCE; NONADHERENCE;
   PREVALENCE; IMPACT; RISK
AB Objective: This descriptive study examined the quality of care received by individuals with serious mental illness observed in clinical care using established Healthcare Effectiveness Data and Information Set (HEDIS) measures for individuals with serious mental illness. Methods: Administrative claims (Medicaid, Medicare, and commercial) from a national health and well-being company were used to identify adults with schizophrenia or bipolar disorder. Performance rates for five HEDIS mental health quality measures were computed. Sub-group analyses examined each HEDIS measure by those who were medication adherent vs non-adherent, and by typical vs atypical antipsychotics. Results: Eighty-nine percent of the Medicaid population received a diabetes screening (vs 79% for national benchmark Medicaid rates), 81% (vs 69%) received monitoring for diabetes, 88% (vs 79%) received monitoring for cardiovascular disease, 63% (vs 60%) were adherent with antipsychotic medication, and 34% (vs 61%) had a follow-up visit with a mental health practitioner within 30 days of a discharge. The rates for individuals with Medicare coverage were similar or marginally higher than those reported for those with Medicaid coverage, while rates for the commercially insured population were lower than the other groups. Conclusions: Most (>65%) individuals with serious mental illness received the recommended screening and monitoring for diabetes and cardiovascular disease. Barriers to and reasons for lack of follow-up should be investigated to guide future interventions to improve follow-up after hospitalization for individuals with serious mental illness.
C1 [Ng-Mak, Daisy; Rajagopalan, Krithika] Sunovion Pharmaceut Inc, Global Hlth Outcomes Res, 84 Waterford Dr, Marlborough, MA 01752 USA.
C3 Dainippon Sumitomo Pharmaceutical Company; Sunovion Pharmaceuticals Inc.
RP Ng-Mak, D (corresponding author), Sunovion Pharmaceut Inc, Global Hlth Outcomes Res, 84 Waterford Dr, Marlborough, MA 01752 USA.
EM daisy.ng-mak@sunovion.com
OI Rajagopalan, Krithika/0000-0002-4878-0822
FU Sunovion Pharmaceuticals Inc.
FX This study was sponsored by Sunovion Pharmaceuticals Inc.
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NR 44
TC 4
Z9 4
U1 1
U2 6
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0300-7995
EI 1473-4877
J9 CURR MED RES OPIN
JI Curr. Med. Res. Opin.
PD JAN 2
PY 2019
VL 35
IS 1
BP 87
EP 95
DI 10.1080/03007995.2018.1532883
PG 9
WC Medicine, General & Internal; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine; Research & Experimental Medicine
GA HF2MO
UT WOS:000454070800013
PM 30286663
OA Bronze
DA 2025-06-11
ER

PT J
AU Phillips, AC
   Batty, GD
   Weiss, A
   Deary, I
   Gale, CR
   Thomas, GN
   Carroll, D
AF Phillips, Anna C.
   Batty, G. David
   Weiss, Alexander
   Deary, Ian
   Gale, Catharine R.
   Thomas, G. Neil
   Carroll, Douglas
TI Neuroticism, cognitive ability, and the metabolic syndrome: The Vietnam
   Experience Study
SO JOURNAL OF PSYCHOSOMATIC RESEARCH
LA English
DT Article
DE Cognitive ability; The metabolic syndrome; Neuroticism; Socioeconomic
   status; Health behaviors; Veterans
ID PERSONALITY-TRAITS; PHYSICAL HEALTH; OLD-AGE; POSTSERVICE MORTALITY;
   MIDDLE-AGE; ALL-CAUSE; LIFE; STRESS; CORTISOL; RISK
AB Objectives: The purpose of this study is to explore the association of neuroticism with the metabolic syndrome, separate components of the metabolic syndrome, and the number of components of metabolic syndrome an individual possesses. The purpose of this study is to examine also the extent to which any associations are accounted for by sociodemographic factors, health behaviors, and cognitive ability. Method: Participants were 4208 men drawn from the Vietnam Experience Study. From military archives, and a later telephone interview and psychological and medical examination, sociodemographic, health behavior, cognitive ability, neuroticism, and health data were collected. Neuroticism and cognitive ability were assessed with standardized tests during the medical examination. Presence of the metabolic syndrome was based on body mass index, fasting blood glucose or a diagnosis of diabetes, high blood pressure or taking antihypertensive medication, high-density lipoprotein cholesterol, and triglyceride levels. Results: Neuroticism was positively associated with the occurrence of the metabolic syndrome and several of its components in both age-, and sociodemographic- and health behavior-adjusted analyses. Many associations were accounted for by individual difference in cognitive ability. Neuroticism was robustly associated with the number of components of the metabolic syndrome after adjustment. Conclusions: Individuals with higher neuroticism scores had a higher prevalence of the metabolic syndrome and a larger number of its components. On the whole, differences in cognitive ability appeared to partially mediate the relationship between neuroticism and the metabolic syndrome. (C) 2010 Elsevier Inc. All rights reserved.
C1 [Phillips, Anna C.; Carroll, Douglas] Univ Birmingham, Sch Sport & Exercise Sci, Birmingham B15 2TT, W Midlands, England.
   [Batty, G. David; Deary, Ian] Univ Edinburgh, Dept Psychol, Ctr Cognit Ageing & Cognit Epidemiol, Edinburgh EH8 9YL, Midlothian, Scotland.
   [Batty, G. David] Univ Glasgow, MRC, Social & Publ Hlth Sci Unit, Glasgow G12 8QQ, Lanark, Scotland.
   [Batty, G. David] Univ Sydney, George Inst Int Hlth, Sydney, NSW 2006, Australia.
   [Weiss, Alexander] Univ Edinburgh, Sch Philosophy Psychol & Language Sci, Dept Psychol, Edinburgh EH8 9YL, Midlothian, Scotland.
   [Gale, Catharine R.] Univ Southampton, MRC, Epidemiol Resource Ctr, Southampton SO9 5NH, Hants, England.
   [Thomas, G. Neil] Univ Birmingham, Sch Med & Dent Sci, Birmingham B15 2TT, W Midlands, England.
C3 University of Birmingham; University of Edinburgh; MRC/CSO SOCIAL AND
   PUBLIC HEALTH SCIENCES UNIT; University of Glasgow; George Institute for
   Global Health; University of Sydney; University of Edinburgh; University
   of Southampton; University of Birmingham
RP Phillips, AC (corresponding author), Univ Birmingham, Sch Sport & Exercise Sci, Birmingham B15 2TT, W Midlands, England.
EM a.c.phillips@bham.ac.uk
RI Gale, Catharine/B-1653-2012; Weiss, Alexander/KRQ-5193-2024; Batty,
   GD/Y-4401-2018; Thomas, G./A-1879-2013; Deary, Ian/C-6297-2009;
   Whittaker, Anna/A-3577-2013
OI Deary, Ian/0000-0002-1733-263X; Whittaker, Anna/0000-0002-5461-0598;
   Batty, George/0000-0003-1822-5753; Thomas, Graham
   Neil/0000-0002-2777-1847; Gale, Catharine/0000-0002-3361-8638
FU MRC; Chief Scientist Office at the Scottish Government Health
   Directorates; Biotechnology and Biological Sciences Research Council;
   Engineering and Physical Sciences Research Council; Economic and Social
   Research Council; University of Edinburgh as part of the cross-council
   Lifelong Health and Wellbeing Initiative; MRC [G0700704,
   MC_UP_A620_1015, MC_U130059821] Funding Source: UKRI
FX The Medical Research Council (MRC) Social and Public Health Services
   Unit receives funding from the MRC and the Chief Scientist Office at the
   Scottish Government Health Directorates. The Centre for Cognitive Ageing
   and Cognitive Epidemiology is supported by the Biotechnology and
   Biological Sciences Research Council, the Engineering and Physical
   Sciences Research Council, the Economic and Social Research Council, the
   MRC, and the University of Edinburgh as part of the cross-council
   Lifelong Health and Wellbeing Initiative. David Batty is a Wellcome
   Trust Fellow (WBS U.1300.00.006.00012.01).
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NR 60
TC 35
Z9 37
U1 0
U2 13
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-3999
EI 1879-1360
J9 J PSYCHOSOM RES
JI J. Psychosomat. Res.
PD AUG
PY 2010
VL 69
IS 2
BP 193
EP 201
DI 10.1016/j.jpsychores.2010.01.016
PG 9
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 631BX
UT WOS:000280322700014
PM 20624519
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Bigalke, JA
   Durocher, JJ
   Greenlund, IM
   Keller-Ross, M
   Carter, JR
AF Bigalke, Jeremy A.
   Durocher, John J.
   Greenlund, Ian M.
   Keller-Ross, Manda
   Carter, Jason R.
TI Blood pressure and muscle sympathetic nerve activity are associated with
   trait anxiety in humans
SO AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
LA English
DT Article
DE anxiety; blood pressure; hypertension; muscle sympathetic nerve
   activity; stress
ID LABORATORY MENTAL STRESS; MYOCARDIAL-INFARCTION; NEURAL RESPONSES;
   SEX-DIFFERENCES; PSYCHOMETRIC PROPERTIES; RISK; REACTIVITY; DISORDER;
   MECHANISMS; YOUNG
AB Chronic anxiety is prevalent and associated with an increased risk of cardiovascular disease. Prior studies that have reported a relationship between muscle sympathetic nerve activity (MSNA) and anxiety have focused on participants with anxiety disorders and/or metabolic syndrome. The present study leverages a large cohort of healthy adults devoid of cardiometabolic disorders to examine the hypothesis that trait anxiety severity is positively associated with resting MSNA and blood pressure. Resting blood pressure (BP) (sphygmomanometer and finger plethysmography), MSNA (microneurography), and heart rate (HR; electrocardiogram) were collected in 88 healthy participants (52 males, 36 females, 25 +/- 1 yr, 25 +/- 1 kg/m2). Multiple linear regression was performed to assess the independent relationship between trait anxiety, MSNA, resting BP, and HR while controlling for age and sex. Trait anxiety was significantly correlated with systolic arterial pressure (SAP; r = 0.251, P = 0.018), diastolic arterial pressure (DAP; r = 0.291, P = 0.006), mean arterial pressure (MAP; r = 0.328, P = 0.002), MSNA burst frequency (BF; r = 0.237, P = 0.026), and MSNA burst incidence (BI; r = 0.225, P = 0.035). When controlling for the effects of age and sex, trait anxiety was independently associated with SAP (3 = 0.206, P = 0.028), DAP (3 = 0.317, P = 0.002), MAP (3 = 0.325, P = 0.001), MSNA BF (3 = 0.227, P = 0.030), and MSNA BI (3 = 0.214, P = 0.038). Trait anxiety is associated with increased blood pressure and MSNA, demonstrating an important relationship between anxiety and autonomic blood pressure regulation.NEW & NOTEWORTHY Anxiety is associated with development of cardiovascular disease. Although the sympathetic nervous system is a likely mediator of this relationship, populations with chronic anxiety have shown little, if any, alteration in resting levels of directly recorded muscle sympathetic nerve activity (MSNA). The present study is the first to reveal an independent relationship between trait anxiety, resting blood pressure, and MSNA in a large cohort of healthy males and females devoid of cardiometabolic comorbidities.
C1 [Bigalke, Jeremy A.; Carter, Jason R.] Montana State Univ, Dept Hlth & Human Dev, Bozeman, MT 59717 USA.
   [Bigalke, Jeremy A.; Greenlund, Ian M.] Montana State Univ, Dept Psychol, Bozeman, MT USA.
   [Bigalke, Jeremy A.; Durocher, John J.; Greenlund, Ian M.; Carter, Jason R.] Michigan Technol Univ, Dept Kinesiol & Integrat Physiol, Houghton, MI 49931 USA.
   [Durocher, John J.] Purdue Univ Northwest, Dept Biol Sci & Integrat Physiol, Hammond, IN USA.
   [Durocher, John J.] Purdue Univ Northwest, Hlth Sci Ctr, Hammond, IN USA.
   [Greenlund, Ian M.] Mayo Clin, Dept Cardiovasc Med, Rochester, MN USA.
   [Keller-Ross, Manda] Univ Minnesota, Div Phys Therapy & Rehabil Sci, Minneapolis, MN USA.
   [Carter, Jason R.] Baylor Univ, Robbins Coll Hlth & Human Sci, Waco, TX 76706 USA.
C3 Montana State University System; Montana State University Bozeman;
   Montana State University System; Montana State University Bozeman;
   Michigan Technological University; Purdue University System; Purdue
   University Northwest; Purdue University System; Purdue University
   Northwest; Mayo Clinic; University of Minnesota System; University of
   Minnesota Twin Cities; Baylor University
RP Carter, JR (corresponding author), Montana State Univ, Dept Hlth & Human Dev, Bozeman, MT 59717 USA.; Carter, JR (corresponding author), Michigan Technol Univ, Dept Kinesiol & Integrat Physiol, Houghton, MI 49931 USA.; Carter, JR (corresponding author), Baylor Univ, Robbins Coll Hlth & Human Sci, Waco, TX 76706 USA.
EM Jason_Carter1@baylor.edu
RI Keller-Ross, Manda/I-5699-2019
OI Bigalke, Jeremy/0000-0002-1653-4563; Keller-Ross,
   Manda/0000-0001-9363-5379
FU National Institutes of Health [AA0024892, 1R15HL140596-01,
   AG064038-01A1, U54GM115371, P20GM103474]; National Center for Advancing
   Translational Sciences of the National Institutes of Health Award [2TL1
   TR002318]
FX This work was supported by National Institutes of Health Grants
   AA0024892, 1R15HL140596-01, AG064038-01A1, U54GM115371, and P20GM103474
   and National Center for Advancing Translational Sciences of the National
   Institutes of Health Award 2TL1 TR002318.
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NR 81
TC 11
Z9 12
U1 0
U2 5
PU AMER PHYSIOLOGICAL SOC
PI Rockville
PA 6120 Executive Blvd, Suite 600, Rockville, MD, UNITED STATES
SN 0363-6135
EI 1522-1539
J9 AM J PHYSIOL-HEART C
JI Am. J. Physiol.-Heart Circul. Physiol.
PD APR
PY 2023
VL 324
IS 4
BP H494
EP H503
DI 10.1152/ajpheart.00026.2023
PG 10
WC Cardiac & Cardiovascular Systems; Physiology; Peripheral Vascular
   Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Physiology
GA H9KP6
UT WOS:000999068500001
PM 36800506
OA Green Published
DA 2025-06-11
ER

PT J
AU Sauvé, MF
   Feldman, F
   Sané, AT
   Koudoufio, M
   Patey, N
   Spahis, S
   Butcher, J
   Duan, HA
   Figeys, D
   Marcil, V
   Stintzi, A
   Levy, E
AF Sauve, Mathilde Foisy
   Feldman, Francis
   Sane, Alain Theophile
   Koudoufio, Mireille
   Patey, Natalie
   Spahis, Schohraya
   Butcher, James
   Duan, Haonan
   Figeys, Daniel
   Marcil, Valerie
   Stintzi, Alain
   Levy, Emile
TI Glycomacropeptide as an Efficient Agent to Fight Pathophysiological
   Mechanisms of Metabolic Syndrome
SO NUTRIENTS
LA English
DT Article
DE milk peptide; metabolic syndrome; gut-liver axis; inflammation;
   oxidative stress; endoplasmic reticulum stress; fatty acids
ID CHAIN FATTY-ACIDS; CASEIN GLYCOMACROPEPTIDE; GUT MICROBIOTA; OBESITY;
   MILK; DIET; HUMANS
AB There is currently a growing interest in the use of nutraceuticals as a means of preventing the development of complex diseases. Given the considerable health potential of milk-derived peptides, the aim of this study was to investigate the protective effects of glycomacropeptide (GMP) on metabolic syndrome. Particular emphasis was placed on the potential mechanisms mitigating cardiometabolic disorders in high-fat, high-fructose diet-fed mice in the presence of GMP or Bipro, an isocaloric control. The administration of GMP for 12 weeks reduced obesity, hyperglycemia and hyperinsulinemia caused by a high-fat, high-fructose diet, resulting in a decline in insulin resistance. GMP also lessened systemic inflammation, as indicated by decreased circulating inflammatory cytokines. In the intestinal and hepatic tissues, GMP improved homeostasis by increasing insulin sensitivity and attenuating high-fat, high-fructose-induced inflammation, oxidative stress and endoplasmic reticulum stress. Biochemical and histological analyses revealed improved hepatic steatosis and fatty acid composition in the livers of high-fat, high-fructose diet-fed mice treated with GMP compared to Bipro. A trend toward a decrease in bile acids without any marked changes in intestinal microbiota composition characterized GMP-treated animals compared to those administered Bipro. GMP offers considerable potential for fighting metabolic syndrome-related components and complications given its beneficial effects on risk factors such as inflammation, oxidative stress and endoplasmic reticulum stress without involving the intestinal microbiota.
C1 [Sauve, Mathilde Foisy; Feldman, Francis; Sane, Alain Theophile; Koudoufio, Mireille; Patey, Natalie; Spahis, Schohraya; Marcil, Valerie; Levy, Emile] St Justine Univ, Hlth Ctr, Res Ctr, Montreal, PQ H3T 1C5, Canada.
   [Sauve, Mathilde Foisy; Feldman, Francis; Koudoufio, Mireille; Marcil, Valerie; Levy, Emile] Univ Montreal, Dept Nutr, Montreal, PQ H3T 1A8, Canada.
   [Patey, Natalie] Univ Montreal, Dept Pathol & Cell Biol, Montreal, PQ H3T 1J4, Canada.
   [Spahis, Schohraya] Univ Montreal, Dept Biochem & Mol Med, Montreal, PQ H3T 1J4, Canada.
   [Butcher, James; Duan, Haonan; Figeys, Daniel; Stintzi, Alain] Univ Ottawa, Ottawa Inst Syst Biol, Dept Biochem Microbiol & Immunol, Ottawa, ON K1H 8M5, Canada.
   [Duan, Haonan; Figeys, Daniel] Univ Ottawa, Sch Pharmaceut Sci, Ottawa, ON K1H 8M5, Canada.
C3 Universite de Montreal; Universite de Montreal; Universite de Montreal;
   Universite de Montreal; University of Ottawa; University of Ottawa
RP Levy, E (corresponding author), St Justine Univ, Hlth Ctr, Res Ctr, Montreal, PQ H3T 1C5, Canada.; Levy, E (corresponding author), Univ Montreal, Dept Nutr, Montreal, PQ H3T 1A8, Canada.
EM mathilde.foisy.sauve@umontreal.ca; francis.feldman@umontreal.ca;
   sanealaintheo@gmail.com; mireille.koudoufio@umontreal.ca;
   natalie.patey.med@ssss.gouv.qc.ca; schohraya.spahis.hsj@ssss.gouv.qc.ca;
   jbutcher@uottawa.ca; hduan084@uottawa.ca; dfigeys@uottawa.ca;
   valerie.marcil@umontreal.ca; astintzi@uottawa.ca;
   emile.levy.hsj@ssss.gouv.qc.ca
RI Butcher, James/AAC-8339-2020
OI Sane, Alain Theophile/0000-0001-6567-1153; Duan,
   Haonan/0000-0002-2753-8594; Feldman, Francis/0000-0003-2758-9305;
   Spahis, Schohraya/0000-0003-4130-4994; Butcher,
   James/0000-0002-7050-1834; Levy, Emile/0000-0001-9983-7027
FU Dairy Farmers of Canada
FX The authors thank A. Rao and P. Ponce (Agropur Dairy Cooperative, Eden
   Prairie, MN, USA) for providing us with GMP and Bipro. We would also
   like to acknowledge Li Zhang for performing the metagenomic DNA
   extractions and constructing the 16S amplicon libraries.
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NR 76
TC 1
Z9 1
U1 0
U2 2
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD MAR
PY 2024
VL 16
IS 6
AR 871
DI 10.3390/nu16060871
PG 29
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA MG3F0
UT WOS:001192426500001
PM 38542783
OA gold
DA 2025-06-11
ER

PT J
AU Mohan, S
   Rani, MRP
   Brown, L
   Ayyappan, P
   Raghu, KG
AF Mohan, Sreelekshmi
   Rani, Preetha M. R.
   Brown, Lindsay
   Ayyappan, Prathapan
   Raghu, K. G.
TI Endoplasmic reticulum stress: A master regulator of metabolic syndrome
SO EUROPEAN JOURNAL OF PHARMACOLOGY
LA English
DT Review
DE ER stress; Unfolded protein response; Diabetes; Obesity; Cardiovascular
   diseases; Liver
ID UNFOLDED PROTEIN RESPONSE; MITOCHONDRIAL PERMEABILITY TRANSITION; NF-Y
   CBF; ER-STRESS; MESSENGER-RNA; THERAPEUTIC TARGET; OXIDATIVE STRESS;
   LIPID-METABOLISM; ADIPOSE-TISSUE; CELL-DEATH
AB Endoplasmic reticulum (ER) stress, a change in the ER homeostasis, leads to initiation of the unfolded protein response (UPR). The primary functions of the UPR are to restore the ER's physiological activity and coordinate the apoptotic and adaptive responses. Pathophysiological conditions that augment ER stress include hypoxia, misfolded and/or mutated protein accumulation, and high glucose. Prolonged ER stress is a critical factor in the pathogenesis of metabolic syndrome including type 2 diabetes mellitus, cardiovascular diseases, atherosclerosis, obesity, and fatty liver disease. UPR is a complex homeostatic pathway between newly synthesized proteins and their maturation, although the regulatory mechanisms contributing to the UPR and the possible therapeutic strategies are yet to be clarified. Therefore, a comprehensive understanding of the underlying molecular mechanisms is necessary to develop therapeutic interventions targeting ER stress response. In this review, we discuss the role of ER stress and UPR signaling in the pathogenesis of metabolic syndrome, highlighting the main functions of UPR components. We have emphasized the use of novel small molecular chemical chaperones, considered as modulators of ER stress. The initial studies with these chemical chaperones are promising, but detailed studies are required to define their efficacy and adverse effects during therapeutic use in humans.
C1 [Mohan, Sreelekshmi; Rani, Preetha M. R.; Raghu, K. G.] CSIR, Biochem & Mol Mech Lab, Agroproc & Technol Div, Natl Inst Interdisciplinary Sci & Technol, Thiruvananthapuram 695019, Kerala, India.
   [Mohan, Sreelekshmi; Rani, Preetha M. R.; Raghu, K. G.] AcSIR, New Delhi, India.
   [Brown, Lindsay] Univ Southern Queensland, Funct Foods Res Grp, Sch Hlth & Wellbeing, Toowoomba, Qld 4350, Australia.
   [Ayyappan, Prathapan] Univ Nebraska, Med Ctr, Dept Surg Transplant, Omaha, NE USA.
C3 Council of Scientific & Industrial Research (CSIR) - India; CSIR -
   National Institute Interdisciplinary Science & Technology (NIIST);
   Academy of Scientific & Innovative Research (AcSIR); University of
   Southern Queensland; University of Nebraska System; University of
   Nebraska Medical Center
RP Raghu, KG (corresponding author), CSIR, Biochem & Mol Mech Lab, Agroproc & Technol Div, Natl Inst Interdisciplinary Sci & Technol, Thiruvananthapuram 695019, Kerala, India.
EM raghukgopal@niist.res.in
RI MUTHUKRISHNAN RENUKA, PREETHA RANI/JKH-6046-2023; Raghu, K/AAT-8042-2021
OI Ayyappan, Prathapan/0000-0002-5508-2360; MUTHUKRISHNAN RENUKA, PREETHA
   RANI/0000-0002-4679-8199
FU University Grants Commission (UGC, New Delhi, India); Council of
   Scientific and Industrial Research (CSIR), Government of India
FX Sreelekshmi Mohan thanks University Grants Commission (UGC, New Delhi,
   India) for providing fellowship to conduct research, on the role of ER
   stress and metabolic syndrome. Preetha Rani M R thanks Council of
   Scientific and Industrial Research (CSIR), Government of India, for
   providing fellowship.
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NR 144
TC 67
Z9 69
U1 0
U2 44
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0014-2999
EI 1879-0712
J9 EUR J PHARMACOL
JI Eur. J. Pharmacol.
PD OCT 5
PY 2019
VL 860
AR 172553
DI 10.1016/j.ejphar.2019.172553
PG 10
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA IU9YA
UT WOS:000483935300010
PM 31325433
DA 2025-06-11
ER

PT J
AU Wilson, C
   Carpenter, J
   Park, S
   McHugh, C
   Scott, EM
   Hickie, IB
AF Wilson, Chloe
   Carpenter, Joanne
   Park, Shinho
   McHugh, Catherine
   Scott, Elizabeth M.
   Hickie, Ian B.
TI Metabolic and clinical profiles of young people with mood or psychotic
   disorders who are prescribed metformin in an inpatient setting
SO AUSTRALASIAN PSYCHIATRY
LA English
DT Article
DE cardiometabolic risk factors; glucose metabolism; insulin-resistance;
   metformin; youth mood and psychotic disorders
ID MENTAL-ILLNESS; ADULTS
AB Objective: Youth with early-onset mood or psychotic disorders are occasionally prescribed metformin to manage cardiometabolic risk. This retrospective study explores the demographic, clinical and metabolic factors associated with metformin prescription youth with mood or psychotic disorders.
   Method: Participants included 72 youth with mood or psychotic disorders from a young adult mental health inpatient unit, of which 18 (33%) were newly prescribed metformin, and 54 (66%) were not prescribed metformin. Demographic and clinical information were extracted from the patients' medical files along with body mass index (BMI), fasting serum bloods and calculated updated homeostatic model of insulin resistance assessment (HOMA2-IR) scores to compare profiles between groups.
   Results: Of those prescribed metformin, 83% were overweight or obese and 72% had elevated HOMA2-IR scores. Of those not receiving metformin treatment, 41% were overweight or obese and 22% had elevated HOMA2-IR scores. Youth prescribed metformin had significantly higher BMI, and elevated markers of insulin resistance, but did not differ to those not prescribed metformin on other demographic, clinical or metabolic factors.
   Conclusions: While metformin is prescribed to some youth with mood or psychotic disorders displaying markers of cardiometabolic disturbance, there is a need to develop clearer treatment guidelines for metformin in these youth.
C1 [Wilson, Chloe; Carpenter, Joanne; Park, Shinho; McHugh, Catherine; Scott, Elizabeth M.; Hickie, Ian B.] Univ Sydney, Brain & Mind Ctr, 94 Mallett St, Camperdown, NSW 2050, Australia.
C3 University of Sydney
RP Wilson, C (corresponding author), Univ Sydney, Brain & Mind Ctr, 94 Mallett St, Camperdown, NSW 2050, Australia.
EM chloe.wilson@sydney.edu.au
RI Carpenter, Joanne/HZK-3629-2023; Hickie, Ian/K-8975-2015
OI Scott, Elizabeth/0000-0003-3907-0324; McHugh,
   Catherine/0000-0002-4891-4966; Hickie, Ian/0000-0001-8832-9895; ,
   Chloe/0000-0001-6539-423X; Park, Shin Ho/0000-0002-1309-0506
FU University of Sydney; philanthropic PhD scholarship (The Liu McCabe
   Family Scholarship); National Health and Medical Research Council
   Australia Fellowship [511921]; Caroline Quinn Research Grant
FX This project is an investigator-initiated study, sponsored by the
   University of Sydney and supported by philanthropic funding, for which
   donor(s) are families affected by mental illness who wish to remain
   anonymous. This study was also partially funded by a philanthropic PhD
   scholarship (The Liu McCabe Family Scholarship awarded to CW), a
   National Health and Medical Research Council Australia Fellowship (No.
   511921, awarded to IBH) and a philanthropic fellowship (the Caroline
   Quinn Research Grant awarded to JC). The funders of this study had no
   involvement in the: study design; collection, analysis and reporting of
   the data; writing of the report or decision to submit the paper for
   publication.
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NR 14
TC 0
Z9 0
U1 0
U2 0
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1039-8562
EI 1440-1665
J9 AUSTRALAS PSYCHIATRY
JI Australas. Psychiatry
PD DEC
PY 2022
VL 30
IS 6
BP 689
EP 693
DI 10.1177/10398562221115607
EA JUL 2022
PG 5
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 8L7NW
UT WOS:000827201000001
PM 35852822
DA 2025-06-11
ER

PT J
AU Maunder, RG
   Tannenbaum, DW
   Permaul, JA
   Nutik, M
   Haber, C
   Mitri, M
   Costantini, D
   Hunter, JJ
AF Maunder, Robert G.
   Tannenbaum, David W.
   Permaul, Joanne A.
   Nutik, Melissa
   Haber, Cleo
   Mitri, Mira
   Costantini, Daniela
   Hunter, Jonathan J.
TI The prevalence and clinical correlates of adverse childhood experiences
   in a cross-sectional study of primary care patients with cardiometabolic
   disease or risk factors
SO BMC CARDIOVASCULAR DISORDERS
LA English
DT Article
DE Childhood adversity; Cardiovascular risk; Prevention; Quality of life
ID QUALITY-OF-LIFE; ABUSE; TRAUMA; ADULTS; QUESTIONNAIRE; DEPRESSION;
   DISORDERS; OUTCOMES; WEIGHT; IMPACT
AB Background Adverse childhood experiences (ACEs) are associated with risk of poor adult health, including cardiometabolic diseases. Little is known about the correlates of ACEs for adults who have already developed cardiometabolic diseases, or who are at elevated risk. Methods Adult primary care patients with cardiometabolic disease (hypertension, diabetes, stroke, angina, myocardial infarction, coronary artery bypass graft, angioplasty) or with a risk factor (obesity, smoking, high cholesterol, family history) were surveyed regarding ACEs, psychological distress, attachment insecurity, quality of life, behavior change goals, stages of change, and attitudes toward potential prevention strategies. Results Of 387 eligible patients, 74% completed the ACEs survey. Exposure to ACEs was reported by 174 participants (61%). Controlling for age, gender, relationship status and income, number of ACEs was associated with psychological distress (F = 3.7, p = .01), quality of life (F = 8.9, p = .001), attachment anxiety (F = 3.4, p = .02), drinking alcohol most days (F = 4.0, p = .008) and smoking (F = 2.7, p = .04). Greater ACE exposure was associated with less likelihood of selecting diet or physical activity as a behavior change goal (linear-by-linear association p = .009). Stage of change was not associated with ACEs. ACEs exposure was not related to preferred resources for behavior change. Conclusions ACEs are common among patients at cardiometabolic risk and are related to quality of life, psychological factors that influence cardiometabolic outcomes and behavior change goals. ACEs should be taken into account when managing cardiometabolic risk in family medicine.
C1 [Maunder, Robert G.; Hunter, Jonathan J.] Sinai Hlth Syst, Dept Psychiat, Toronto, ON, Canada.
   [Maunder, Robert G.; Hunter, Jonathan J.] Univ Toronto, Toronto, ON, Canada.
   [Tannenbaum, David W.; Permaul, Joanne A.; Nutik, Melissa; Mitri, Mira; Costantini, Daniela] Univ Toronto, Ray D Wolfe Dept Family Med, Sinai Hlth Syst, Toronto, ON, Canada.
   [Tannenbaum, David W.; Nutik, Melissa; Haber, Cleo; Mitri, Mira; Costantini, Daniela] Univ Toronto, Dept Family & Community Med, Toronto, ON, Canada.
   [Haber, Cleo] Univ Toronto, Mt Sinai Acad Team, Ray D Wolfe Dept Family Med, Sinai Hlth Syst, Toronto, ON, Canada.
C3 University of Toronto; Sinai Health System Toronto; Lunenfeld Tanenbaum
   Research Institute; University of Toronto; University of Toronto; Sinai
   Health System Toronto; Lunenfeld Tanenbaum Research Institute;
   University of Toronto; University of Toronto; Sinai Health System
   Toronto; Lunenfeld Tanenbaum Research Institute
RP Maunder, RG (corresponding author), Sinai Hlth Syst, Dept Psychiat, Toronto, ON, Canada.; Maunder, RG (corresponding author), Univ Toronto, Toronto, ON, Canada.
EM robert.maunder@sinaihealthsystem.ca
RI Maunder, Robert/B-1687-2008
OI Maunder, Robert/0000-0001-9309-3899
FU Departments of Family Medicine and Psychiatry of Sinai Health System
FX This study was funded by the Departments of Family Medicine and
   Psychiatry of Sinai Health System. The funders had no role in the design
   of the study, nor in collection, analysis, and interpretation of data,
   nor in writing the manuscript.
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NR 36
TC 13
Z9 14
U1 0
U2 13
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1471-2261
J9 BMC CARDIOVASC DISOR
JI BMC Cardiovasc. Disord.
PD DEC 19
PY 2019
VL 19
IS 1
AR 304
DI 10.1186/s12872-019-01277-3
PG 10
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Cardiovascular System & Cardiology
GA JY9WM
UT WOS:000504756200003
PM 31881981
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Otamas, A
   Grant, PJ
   Ajjan, RA
AF Otamas, Anastasia
   Grant, Peter J.
   Ajjan, Ramzi A.
TI Diabetes and atherothrombosis: The circadian rhythm and role of
   melatonin in vascular protection
SO DIABETES & VASCULAR DISEASE RESEARCH
LA English
DT Review
DE Diabetes; freestyle libre; mean average relative difference;
   interstitial fluid glucose; hypoglycaemia
ID CORONARY-HEART-DISEASE; INSULIN-RESISTANCE; CARDIOVASCULAR-DISEASE;
   METABOLIC SYNDROME; SHIFT WORK; ENDOTHELIAL DYSFUNCTION; OXIDATIVE
   STRESS; HUMAN PLATELETS; RISK-FACTORS; FACTOR-VII
AB Obesity-related euglycaemic insulin resistance clusters with cardiometabolic risk factors, contributing to the development of both type 2 diabetes and cardiovascular disease. An increased thrombotic tendency in diabetes stems from platelet hyperactivity, enhanced activity of prothrombotic coagulation factors and impaired fibrinolysis. Furthermore, a low-grade inflammatory response and increased oxidative stress accelerate the atherosclerotic process and, together with an enhanced thrombotic environment, result in premature and more severe cardiovascular disease. The disruption of circadian cycles in man secondary to chronic obesity and loss of circadian cues is implicated in the increased risk of developing diabetes and cardiovascular disease. Levels of melatonin, the endogenous synchronizer of circadian rhythm, are reduced in individuals with vascular disease and those with deranged glucose metabolism. The anti-inflammatory, antihypertensive, antioxidative and antithrombotic activities of melatonin make it a potential therapeutic agent to reduce the risk of vascular occlusive disease in diabetes. The mechanisms behind melatonin-associated reduction in procoagulant response are not fully known. Current evidence suggests that melatonin inhibits platelet aggregation and might affect the coagulation cascade, altering fibrin clot structure and/or resistance to fibrinolysis. Large-scale clinical trials are warranted to investigate the effects of modulating the circadian clock on insulin resistance, glycaemia and cardiovascular outcome.
C1 [Otamas, Anastasia; Grant, Peter J.; Ajjan, Ramzi A.] Univ Leeds, Leeds Inst Cardiovasc & Metab Med, LIGHT Labs, Leeds LS2 9JT, W Yorkshire, England.
   [Otamas, Anastasia; Grant, Peter J.; Ajjan, Ramzi A.] Univ Leeds, Leeds Teaching Hosp Trust, Leeds LS2 9JT, W Yorkshire, England.
C3 University of Leeds; University of Leeds
RP Ajjan, RA (corresponding author), Univ Leeds, Leeds Inst Cardiovasc & Metab Med, LIGHT Labs, Leeds LS2 9JT, W Yorkshire, England.; Ajjan, RA (corresponding author), Univ Leeds, Leeds Teaching Hosp Trust, Leeds LS2 9JT, W Yorkshire, England.
EM r.ajjan@leeds.ac.uk
RI Grant, Peter/HIR-3733-2022; Ajjan, Ramzi/MBG-5025-2025
OI Otamas, Anastasia/0000-0002-2796-434X
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NR 196
TC 18
Z9 18
U1 0
U2 15
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1479-1641
EI 1752-8984
J9 DIABETES VASC DIS RE
JI Diabetes Vasc. Dis. Res.
PD MAY
PY 2020
VL 17
IS 3
AR 1479164120920582
DI 10.1177/1479164120920582
PG 13
WC Endocrinology & Metabolism; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Cardiovascular System & Cardiology
GA MM3EY
UT WOS:000550039300004
PM 32506946
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU O'Brien, J
   Powell, LW
AF O'Brien, Julia
   Powell, Lawrie W.
TI Non-alcoholic fatty liver disease: is iron relevant?
SO HEPATOLOGY INTERNATIONAL
LA English
DT Review
DE Fatty liver disease; Steatohepatitis; Iron overload
ID INSULIN-RESISTANCE SYNDROME; ADVANCED HEPATIC-FIBROSIS;
   TRANSFERRIN-BOUND IRON; HEPATOCELLULAR-CARCINOMA; METABOLIC SYNDROME;
   LIPID-PEROXIDATION; NATURAL-HISTORY; HFE MUTATIONS; CRYPTOGENIC
   CIRRHOSIS; RISK-FACTORS
AB Non-alcoholic fatty liver disease (NAFLD) is a common and ubiquitous disorder (Bedogni et al. in Hepatology 42: 44-52, 2005; Bellentani et al. in Ann Intern Med 132:112-117, 2000) which in a proportion of subjects leads to non-alcoholic steatohepatitis (NASH), advanced liver disease and hepatocellular carcinoma. Although the factors responsible for progression of disease are still uncertain, there is evidence that insulin resistance (IR) is a key operative mechanism (Angulo et al. in Hepatology 30:1356-1362, 1999) and that two stages are involved. The first is the accumulation of triglycerides in hepatocytes followed by a "second hit" which promotes cellular oxidative stress. Several factors may be responsible for the induction of oxidative stress but hepatic iron has been implicated in various studies. The topic is controversial, however, with early studies showing an association between hepatic iron (with or without hemochromatosis gene mutations) and the progression to hepatic fibrosis. Subsequent studies, however, could not confirm an association between the presence of hepatic iron and any of the histological determinants of NAFLD or NASH. Recent studies have reactivated interest in this subject firstly, with the demonstration that hepatic iron loading increases liver cholesterol synthesis with increased lipid deposition in the liver increasing the cellular lipid burden and secondly, a large clinical study has concluded that hepatocellular iron deposition is associated with an increased risk of hepatic fibrosis, thus, strongly supporting the original observation made over a decade ago. An improvement in insulin sensitivity has been demonstrated following phlebotomy therapy but a suitably powered controlled clinical trial is required before this treatment can be implemented.
C1 [Powell, Lawrie W.] Royal Brisbane & Womens Hosp, Ctr Adv Clin Res, Brisbane, Qld 4029, Australia.
   [Powell, Lawrie W.] Univ Queensland, Clin Res Ctr, Brisbane, Qld 4029, Australia.
   [O'Brien, Julia] Royal Brisbane & Womens Hosp, Dept Gastroenterol & Hepatol, Brisbane, Qld 4029, Australia.
C3 Royal Brisbane & Women's Hospital; University of Queensland; Royal
   Brisbane & Women's Hospital
RP Powell, LW (corresponding author), Royal Brisbane & Womens Hosp, Ctr Adv Clin Res, Brisbane, Qld 4029, Australia.
EM lawrie.powell@qimr.edu.au
FU National Health and Medical Research Council of Australia
FX LWP is supported by a project grant from the National Health and Medical
   Research Council of Australia.
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NR 126
TC 29
Z9 29
U1 0
U2 19
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1936-0533
EI 1936-0541
J9 HEPATOL INT
JI Hepatol. Int.
PD JAN
PY 2012
VL 6
IS 1
BP 332
EP 341
DI 10.1007/s12072-011-9304-9
PG 10
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 893NO
UT WOS:000300362800002
PM 22020821
DA 2025-06-11
ER

PT J
AU Delpierre, C
   Fantin, R
   Barboza-Solis, C
   Lepage, B
   Darnaudéry, M
   Kelly-Irving, M
AF Delpierre, C.
   Fantin, R.
   Barboza-Solis, C.
   Lepage, B.
   Darnaudery, M.
   Kelly-Irving, M.
TI The early life nutritional environment and early life stress as
   potential pathways towards the metabolic syndrome in mid-life? A
   lifecourse analysis using the 1958 British Birth cohort
SO BMC PUBLIC HEALTH
LA English
DT Article
DE Metabolic syndrome; Early nutritional exposure; Early psychosocial
   exposures; Cohort studies; Social epidemiology; Lifecourse
ID ADVERSE CHILDHOOD EXPERIENCES; CARDIOVASCULAR-DISEASE; RISK-FACTORS;
   SOCIOECONOMIC POSITION; DIFFERENT DEFINITIONS; CARDIOMETABOLIC RISK;
   OFFSPRING ADIPOSITY; COURSE ORIGINS; OBESITY; HEALTH
AB Background: Lifecourse studies suggest that the metabolic syndrome (MetS) may be rooted in the early life environment. This study aims to examine the pathways linking early nutritional and psychosocial exposures and the presence of MetS in midlife.
   Methods: Data are from the National Child Development Study including individuals born during 1 week in 1958 in Great Britain and followed-up until now. MetS was defined based on the National Cholesterol Education Program Adult Treatment Panel III classification. Mother's pre-pregnancy body mass index (BMI) was used as a proxy of the early nutritional environment and Adverse Childhood Experiences (ACE) as a proxy for early psychosocial stress. Socioeconomic characteristics, pregnancy and birth conditions were extracted as potential confounders. Adult health behaviors, BMI, socioeconomic environment and psychological state were considered as mediating variables. Multivariate models were performed by including variables sequentially taking a lifecourse approach.
   Results: 37.5 % of men and 19.8 % of women had MetS. Participants with an obese/overweight mother presented a higher risk of MetS than those whose mother had a normal pre-pregnancy BMI. Men exposed to two ACE or more, and women exposed to one ACE, were more at risk of MetS compared to unexposed individuals. After including confounders and mediators, mother's pre-pregnancy BMI was still associated with MetS in midlife but the association was weakened after including participant's adult BMI. ACE was no longer associated with MetS after including confounders in models.
   Conclusions: The early nutritional environment, represented by mother's pre-pregnancy BMI, was associated with the risk of MetS in midlife. An important mechanism involves a mother-to-child BMI transmission, independent of birth or perinatal conditions, socioeconomic characteristics and health behaviors over the lifecourse. However this mechanism is not sufficient for explaining the influence of mother's pre-pregnancy BMI which implies the need to further explore other mechanisms in particular the role of genetics and early nutritional environment. ACE is not independently associated with MetS. However, other early life stressful events such as emergency caesarean deliveries and poor socioeconomic status during childhood may contribute as determinants of MetS.
C1 [Delpierre, C.; Fantin, R.; Barboza-Solis, C.; Lepage, B.; Kelly-Irving, M.] INSERM, UMR1027, F-31000 Toulouse, France.
   [Delpierre, C.; Fantin, R.; Barboza-Solis, C.; Lepage, B.; Kelly-Irving, M.] Univ Toulouse 3, UMR1027, F-31000 Toulouse, France.
   [Barboza-Solis, C.] Univ Costa Rica, San Jose 2060, Costa Rica.
   [Lepage, B.] Ctr Hosp Univ Toulouse, Dept Epidemiol, Toulouse, France.
   [Darnaudery, M.] Univ Bordeaux, Lab NUTRINEURO, UMR 1286, F-33076 Bordeaux, France.
   [Darnaudery, M.] INRA, Lab NUTRINEURO, UMR 1286, F-33076 Bordeaux, France.
C3 Institut National de la Sante et de la Recherche Medicale (Inserm);
   Universite de Toulouse; Universite Toulouse III - Paul Sabatier;
   Universite de Toulouse; Universite Toulouse III - Paul Sabatier;
   Universidad Costa Rica; Universite de Toulouse; Universite Toulouse III
   - Paul Sabatier; CHU de Toulouse; Universite de Bordeaux; Institut
   National de la Sante et de la Recherche Medicale (Inserm); Universite de
   Bordeaux; Institut National de la Sante et de la Recherche Medicale
   (Inserm); INRAE
RP Delpierre, C (corresponding author), INSERM, UMR1027, F-31000 Toulouse, France.; Delpierre, C (corresponding author), Univ Toulouse 3, UMR1027, F-31000 Toulouse, France.
EM cyrille.delpierre@inserm.fr
RI Lepage, Benoit/AAD-6193-2021; Fantin, Romain/AAJ-2500-2020; Barboza
   Solis, Cristina/AAB-9922-2020; LEPAGE, Benoit/C-1228-2011; Kelly-Irving,
   Michelle/G-3151-2010
OI delpierre, cyrille/0000-0002-0831-080X; Fantin,
   Romain/0000-0003-2906-3438; Barboza Solis, Cristina/0000-0002-7208-7374;
   LEPAGE, Benoit/0000-0002-1586-2055; DARNAUDERY,
   Muriel/0000-0003-0209-3880; Kelly-Irving, Michelle/0000-0001-5749-4791
FU Agence Nationale de la Recherche [ANR-12-DSSA-0004]; Fond Francais pour
   l'Alimentation et la Sante [12 D-25]; ESRC [ES/M001660/1] Funding
   Source: UKRI; Agence Nationale de la Recherche (ANR) [ANR-12-DSSA-0004]
   Funding Source: Agence Nationale de la Recherche (ANR)
FX The present work is part of the Incorporation Biologique et Inegalites
   Sociales de Sante project supported by funds from Agence Nationale de la
   Recherche (ANR-12-DSSA-0004) and the Fond Francais pour l'Alimentation
   et la Sante (12 D-25).
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NR 61
TC 31
Z9 34
U1 0
U2 14
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2458
J9 BMC PUBLIC HEALTH
JI BMC Public Health
PD AUG 18
PY 2016
VL 16
AR 815
DI 10.1186/s12889-016-3484-0
PG 19
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA DT5VG
UT WOS:000381550600001
PM 27538482
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Jimenez, DE
   Weinstein, ER
   Batsis, JA
AF Jimenez, Daniel E.
   Weinstein, Elliott R.
   Batsis, John A.
TI "Me Dieron Vida": The Effects of a Pilot Health Promotion Intervention
   to Reduce Cardiometabolic Risk and Improve Behavioral Health among Older
   Latinos with HIV
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Article
DE older Latinos; HIV; health promotion; cardiometabolic risk
ID HUMAN-IMMUNODEFICIENCY-VIRUS; PHYSICAL-ACTIVITY; UNITED-STATES;
   PREVALENCE; HIV/AIDS; DISEASE; PEOPLE; IMPACT; STIGMA; PARTICIPATION
AB There are significant gaps in knowledge about the synergistic and disparate burden of health disparities associated with cardiovascular health issues, poorer mental health outcomes, and suboptimal HIV-care management on the health of older Latinos living with HIV (OLLWH). This pilot study sought to evaluate the feasibility and acceptability of an innovative application of an already established health-promotion intervention-Happy Older Latinos are Active (HOLA)-among this marginalized population. Eighteen self-identified Latino men with an undetectable HIV viral load and documented risk of cardiometabolic disease participated in this study. Although the attrition rate of 22% was higher than expected, participants attended 77% of the sessions and almost 95% of the virtual walks. Participants reported high satisfaction with the intervention, as evident by self-report quantitative (CSQ-8; M = 31, SD = 1.5) and qualitative metrics. Participants appreciated bonding with the community health worker and their peers to reduce social isolation. Results indicate that the HOLA intervention is an innovative way of delivering a health promotion intervention adapted to meet the diverse needs and circumstances of OLLWH, is feasible and acceptable, and has the potential to have positive effects on the health of OLLWH.
C1 [Jimenez, Daniel E.] Univ Miami, Miller Sch Med, Dept Psychiat, Miami, FL 33136 USA.
   [Weinstein, Elliott R.] Univ Miami, Dept Psychol, Coral Gables, FL 33146 USA.
   [Batsis, John A.] Univ N Carolina, Div Geriatr Med, Dept Med, Sch Med, Chapel Hill, NC 27599 USA.
   [Batsis, John A.] Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Nutr, Chapel Hill, NC 27599 USA.
C3 University of Miami; University of Miami; University of North Carolina;
   University of North Carolina Chapel Hill; University of North Carolina
   School of Medicine; University of North Carolina; University of North
   Carolina Chapel Hill
RP Jimenez, DE (corresponding author), Univ Miami, Miller Sch Med, Dept Psychiat, Miami, FL 33136 USA.
EM dej18@miami.edu; erw73@miami.edu; john.batsis@unc.edu
RI Batsis, John/AAC-7185-2019
OI Jimenez, Daniel E./0000-0003-2135-0619; Weinstein,
   Elliott/0000-0002-5085-7470; Batsis, John/0000-0002-0845-4416
FU National Institute on Minority Health and Health Disparities [R01
   MD012610, U54 MD002266]; National Institute on Aging [K23-AG051681, RO1
   AG053163]; National Institute on Minority Health and Health Disparities
   [U54MD002266, R01MD012610] Funding Source: NIH RePORTER
FX FundingThis research was supported by grants R01 MD012610 and U54
   MD002266 from the National Institute on Minority Health and Health
   Disparities and RO1 AG053163 from the National Institute on Aging. Dr.
   Batsis is supported by K23-AG051681 from the National Institute on
   Aging.
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NR 68
TC 6
Z9 6
U1 0
U2 4
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD MAR
PY 2022
VL 19
IS 5
AR 2667
DI 10.3390/ijerph19052667
PG 12
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA ZW5KQ
UT WOS:000771252000001
PM 35270360
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Abbas, AM
   Elsamanoudy, AZ
AF Abbas, Amr M.
   Elsamanoudy, Ayman Z.
TI Effects of 17β-estradiol and antioxidant administration on oxidative
   stress and insulin resistance in ovariectomized rats
SO CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
LA English
DT Article
DE 17 beta-estradiol; vitamin E; ovariectomy; brain cortex; liver;
   oxidative stress; antioxidant level
ID HORMONE REPLACEMENT THERAPY; VITAMIN-E; POSTMENOPAUSAL WOMEN;
   LIPID-PEROXIDATION; METABOLIC SYNDROME; ALPHA-TOCOPHEROL;
   ADIPOSE-TISSUE; BRAIN CORTEX; RISK-FACTORS; SENSITIVITY
AB The prevalence of insulin resistance syndrome increases during menopause with the overproduction of reactive oxygen species and impairment of the free radical scavenger function. Therefore, we investigated the effects of 17 beta-estradiol (E-2) and vitamin E, as an antioxidant, on lipid peroxidation and antioxidant levels in the brain cortex and liver of ovariectomized rats as well as on insulin resistance in those rats. Forty female Sprague-Dawley rats, 3 months of age and weighing 231.5 +/- 9.4 g, were divided into 4 groups: sham, ovariectomized (OVX), OVX treated with E-2 (40 mu g/kg subcutaneously), and OVX treated with E-2 and vitamin E (100 mg/kg intraperitoneally). The 4 groups received the appropriate treatment every day for 8 weeks. Levels of glutathione, glutathione peroxidase, superoxide dismutase, catalase, and malondialdehyde in the brain cortex and liver of ovariectomized rats were measured. Also, fasting plasma insulin, glucose, and homeostatis model assessment of insulin resistance (HOMA-IR) were determined. Malondialdehyde increased and antioxidants (glutathione, glutathione peroxidase, catalase, superoxide dismutase) decreased in the brain cortex and liver of OVX rats. Also, fasting glucose, insulin, and HOMA-IR increased in OVX rats. E-2 and E-2 plus vitamin E decreased malondialdehyde and increased antioxidants in the brain cortex and liver of OVX rats. Moreover, they decreased fasting glucose, insulin, and HOMA-IR in ovariectomized rats. This study demonstrates that E-2 and E-2 plus vitamin E supplementation to OVX rats may improve insulin resistance, strengthen the antioxidant system, and reduce lipid peroxidation.
C1 [Abbas, Amr M.] Mansoura Univ, Dept Med Physiol, Fac Med, Mansoura, Egypt.
   [Elsamanoudy, Ayman Z.] Mansoura Univ, Dept Med Biochem, Fac Med, Mansoura, Egypt.
C3 Egyptian Knowledge Bank (EKB); Mansoura University; Egyptian Knowledge
   Bank (EKB); Mansoura University
RP Abbas, AM (corresponding author), Mansoura Univ, Dept Med Physiol, Fac Med, POB 35516, Mansoura, Egypt.
EM dr_amromedhat2006@yahoo.com
RI Elsamanoudy, Ayman/M-6529-2018; Abbas, Amr/G-6979-2017
OI Elsamanoudy, Ayman/0000-0002-8731-6184; Abbas, Amr/0000-0001-6525-7673
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NR 70
TC 43
Z9 48
U1 0
U2 6
PU CANADIAN SCIENCE PUBLISHING
PI OTTAWA
PA 65 AURIGA DR, SUITE 203, OTTAWA, ON K2E 7W6, CANADA
SN 0008-4212
EI 1205-7541
J9 CAN J PHYSIOL PHARM
JI Can. J. Physiol. Pharmacol.
PD JUL
PY 2011
VL 89
IS 7
BP 497
EP 504
DI 10.1139/Y11-053
PG 8
WC Pharmacology & Pharmacy; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Physiology
GA 818XA
UT WOS:000294788500005
PM 21812527
DA 2025-06-11
ER

PT J
AU Barat, P
   Duclos, M
   Gatta, B
   Roger, P
   Mormede, P
   Moisan, MP
AF Barat, P
   Duclos, M
   Gatta, B
   Roger, P
   Mormede, P
   Moisan, MP
TI Corticosteroid binding globulin gene polymorphism influences cortisol
   driven fat distribution in obese women
SO OBESITY RESEARCH
LA English
DT Article
DE glucocorticoid receptor; transcortin; hypothalamo-pituitary-adrenal
   axis; fat mass distribution
ID PITUITARY-ADRENAL AXIS; GLUCOCORTICOID-RECEPTOR GENE; INSULIN-RESISTANCE
   SYNDROME; METABOLIC SYNDROME; ABDOMINAL OBESITY; ASSOCIATION;
   DEFICIENCY; SECRETION; STRESS; TISSUE
AB Hypothalamo-pituitary-adrenal axis has been reported to influence fat mass distribution in obesity. We investigated the hypothesis that corticosteroid-binding globulin (CBG) polymorphism could influence obesity, metabolic, or hypothalamo-pituitary adrenal (HPA) axis activity parameters. In 44 obese pre-menopausal women, a microsatellite located within the CBG gene was analyzed, providing three genotypes: 86/86 (n = 29), 86/90 (n = 14), and 90/90 (n = 1). No significant difference was found for obesity, metabolic, and HPA axis activity parameters between the genotypes 86/86 and 86/90. Looking for differences in correlations between HPA axis activity parameters and obesity or metabolic parameters between the two genotypes, genotype 86/90 showed a strong correlation between salivary cortisol after dexamethasone (0.25 mg) suppression test and waist-to-hip ratio (r = -0.84, p = 0.0007), whereas this correlation was weaker for genotype 86/86 (r = -0.34, p = 0.09). These data were completed with an analysis of the BclI polymorphism of the glucocorticoid receptor (GR) gene. There was an association between this GR polymorphism and both awakening salivary cortisol and postdexamethasone salivary cortisol but no association for obesity or metabolic parameters. We concluded that CBG gene polymorphisms might modulate the influence of the HPA axis on the fat mass distribution in this population.
C1 Univ Bordeaux 2, Inst Francois Magendie, INRA UMR1243, Lab Neurogenet & Stress, F-33077 Bordeaux, France.
   CHU Bordeaux, Endocrinol Unit, Pessac, France.
C3 Universite de Bordeaux; INRAE; CHU Bordeaux
RP Univ Bordeaux 2, Inst Francois Magendie, INRA UMR1243, Lab Neurogenet & Stress, Rue Camille St Saens, F-33077 Bordeaux, France.
EM moisan@bordeaux.inserm.fr
RI Mormede, Pierre/N-3918-2019; Moisan, Marie-Pierre/AAO-9971-2021; Duclos,
   Martine/AAI-5684-2020; Barat, Pascal/E-4013-2017; Mormede,
   Pierre/K-5537-2015
OI Mormede, Pierre/0000-0003-0345-1432; Cherifi,
   Blandine/0000-0002-7399-1330; BARAT, Pascal/0000-0001-5029-0200; Moisan,
   Marie-Pierre/0000-0001-7315-5319
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NR 17
TC 27
Z9 29
U1 0
U2 2
PU NORTH AMER ASSOC STUDY OBESITY
PI SILVER SPRING
PA 8630 FENTON ST, SUITE 918, SILVER SPRING, MD 20910 USA
SN 1071-7323
J9 OBES RES
JI Obes. Res.
PD SEP
PY 2005
VL 13
IS 9
BP 1485
EP 1490
DI 10.1038/oby.2005.179
PG 6
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 974KC
UT WOS:000232589300001
PM 16222046
OA Bronze
DA 2025-06-11
ER

PT J
AU van Donkelaar, EL
   Vaessen, KRD
   Pawluski, JL
   Sierksma, AS
   Blokland, A
   Cañete, R
   Steinbusch, HWM
AF van Donkelaar, Eva L.
   Vaessen, Koen R. D.
   Pawluski, Jodi L.
   Sierksma, Annerieke S.
   Blokland, Arjan
   Canete, Ramon
   Steinbusch, Harry W. M.
TI Long-Term Corticosterone Exposure Decreases Insulin Sensitivity and
   Induces Depressive-Like Behaviour in the C57BL/6NCrl Mouse
SO PLOS ONE
LA English
DT Article
ID FORCED SWIMMING TEST; ALZHEIMERS-DISEASE; METABOLIC SYNDROME;
   ANIMAL-MODEL; GLUCOSE-TOLERANCE; IN-VIVO; RESISTANCE; STRESS; MICE;
   ANTIDEPRESSANTS
AB Chronic stress or long-term administration of glucocorticoids disrupts the hypothalamus-pituitary-adrenal system leading to continuous high levels of glucocorticoids and insulin resistance (IR). This pre-diabetic state can eventually develop into type 2 diabetes mellitus and has been associated with a higher risk to develop depressive disorders. The mechanisms underlying the link between chronic stress, IR and depression remains unclear. The present study aimed to establish a stress-depression model in mice to further study the effects of stress-induced changes upon insulin sensitivity and behavioural consequences. A pilot study was conducted to establish the optimal administration route and a pragmatic measurement of IR. Subsequently, 6-month-old C57BL/6NCrl mice were exposed to long-term oral corticosterone treatment via the drinking water. To evaluate insulin sensitivity changes, blood glucose and plasma insulin levels were measured at different time-points throughout treatment and mice were behaviourally assessed in the elevated zero maze (EZM), forced swimming test (FST) and open field test to reveal behavioural changes. Long-term corticosterone treatment increased body weight and decreased insulin sensitivity. The latter was revealed by a higher IR index and increased insulin in the plasma, whereas blood glucose levels remained unchanged. Corticosterone treatment induced longer immobility times in the FST, reflecting depressive-like behaviour. No effects were observed upon anxiety as measured in the EZM. The effect of the higher body weight of the CORT treated animals at time of testing did not influence behaviour in the EZM or FST, as no differences were found in general locomotor activity. Long-term corticosterone treatment via the drinking water reduces insulin sensitivity and induces depressive-like behaviour in the C57BL/6 mouse. This mouse model could thus be used to further explore the underlying mechanisms of chronic stress-induced T2DM and its association with increased prevalence of major depressive disorder on the short-term and other behavioural adaptations on the longer term.
C1 [van Donkelaar, Eva L.; Vaessen, Koen R. D.; Pawluski, Jodi L.; Sierksma, Annerieke S.; Steinbusch, Harry W. M.] Maastricht Univ, Fac Hlth Med & Life Sci, Sch Mental Hlth & Neurosci, Maastricht, Netherlands.
   [Vaessen, Koen R. D.] Univ Utrecht, Fac Vet Med, Cent Lab Anim Res Facil, Utrecht, Netherlands.
   [Pawluski, Jodi L.] Univ Liege, GIGA Neurosci, Liege, Belgium.
   [Pawluski, Jodi L.] Ohio Univ, Dept Biol Sci, Athens, OH 45701 USA.
   [Sierksma, Annerieke S.] VIB Ctr Biol Dis, Leuven, Belgium.
   [Sierksma, Annerieke S.] Katholieke Univ Leuven, Ctr Human Genet, Leuven, Belgium.
   [Blokland, Arjan] Maastricht Univ, Fac Psychol & Neurosci, Dept Neuropsychol & Psychopharmacol, Maastricht, Netherlands.
   [Canete, Ramon] Hosp Univ Reina Sofia, Inst Maimonides Invest Biomed Cordoba IMIBIC, Unidad Endocrinol Pediat, Cordoba, Spain.
C3 Maastricht University; Utrecht University; University of Liege;
   University System of Ohio; Ohio University; Flanders Institute for
   Biotechnology (VIB); KU Leuven; Maastricht University
RP van Donkelaar, EL (corresponding author), Maastricht Univ, Fac Hlth Med & Life Sci, Sch Mental Hlth & Neurosci, Maastricht, Netherlands.
EM eva.vandonkelaar@maastrichtuniversity.nl
RI Pawluski, Jodi/K-5801-2015; Steinbusch, Heinrich/L-6950-2017; Sierksma,
   Annerieke/L-7990-2016
OI Pawluski, Jodi/0000-0002-8240-8178; Sierksma,
   Annerieke/0000-0001-9233-972X
FU Internationale Stichting Alzheimer Onderzoek (ISAO) [09551]; ZonNW
   [114024017]
FX EVD was financially supported by the Internationale Stichting Alzheimer
   Onderzoek (ISAO, grant number 09551; https://www.alzheimer.nl/) and
   ZonNW (grant number 114024017; http://www.zonmw.nl/nl/). The funders had
   no role in study design, data collection and analysis, decision to
   publish, or preparation of the manuscript.
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NR 49
TC 50
Z9 52
U1 0
U2 21
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD OCT 13
PY 2014
VL 9
IS 10
AR e106960
DI 10.1371/journal.pone.0106960
PG 10
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA AQ9WZ
UT WOS:000343210300003
PM 25310187
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Cardona, F
   Tunez, I
   Tasset, I
   Murri, M
   Tinahones, FJ
AF Cardona, F.
   Tunez, I.
   Tasset, I.
   Murri, M.
   Tinahones, F. J.
TI Similar increase in oxidative stress after fat overload in persons with
   baseline hypertriglyceridemia with or without the metabolic syndrome
SO CLINICAL BIOCHEMISTRY
LA English
DT Article
DE oxidative stress; postprandial hypertriglyceridemia; metabolic syndrome;
   fat overload
ID LOW-DENSITY-LIPOPROTEIN; POSTPRANDIAL LIPEMIA; INSULIN-RESISTANCE;
   CARBOHYDRATE INTAKE; DIABETES-MELLITUS; DIETARY-FAT; COMPLICATIONS;
   PLASMA; CELLS; RISK
AB Objective: We compared the levels of biomarkers of oxidative stress before and after a fat overload in three groups.
   Materials and methods: 17 controls and two groups with hypertriglyceridemia: 43 without the metabolic syndrome (TG-non-MS) and 29 with the metabolic syndrome (TG-MS). All subjects underwent a 60 g fat overload. Baseline measurements included glucose, BMI (body mass index), waist circumference and HOMA IR (homeostasis model assessment insulin resistance). Cholesterol, triglycerides, HDL (high density lipoprotein) cholesterol, TNF-alpha (tumor necrosis factor) and IL-6 (interleukin-6), lipoperoxide (LPO), carbonylated proteins, reduced glutathione (GSH), oxidized glutathione (GSSG), glutathione peroxidase (GSH-PX), glutathione reductase (GSH-Rd), catalase and glutathione transferase (GST) were measured at baseline and 3 h after fat overload.
   Results: Compared to the controls, the two patient groups had higher plasma levels at baseline and after overload of cholesterol, triglycerides and apolipoprotein B, LPO, carbonylated proteins and GSSG, and lower levels of antioxidants at baseline and after the fat overload.
   Conclusion: The two patient groups had the same degree of oxidative stress. (c) 2008 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
C1 [Cardona, F.; Murri, M.; Tinahones, F. J.] Hosp Clin Univ Virgen Victoria, Serv Endocrinol & Nutr, Malaga 29009, Spain.
   [Cardona, F.; Murri, M.; Tinahones, F. J.] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr CB06 03, Madrid, Spain.
   [Tunez, I.; Tasset, I.] Univ Cordoba, Fac Med, Dept Bioquim & Biol Mol, E-14071 Cordoba, Spain.
C3 Hospital Virgen de la Victoria; CIBER - Centro de Investigacion
   Biomedica en Red; CIBEROBN; Instituto de Salud Carlos III; Universidad
   de Cordoba
RP Tinahones, FJ (corresponding author), Care of Montalban MV, 1 Rincon Victoria, Malaga 29720, Spain.
EM fjtinahones@terra.es
RI Tinahones, Francisco/AAB-2882-2020; Cardona, Fernando/AAG-7835-2019;
   Cuevas, Inmaculada/R-4509-2019; Cardona, Fernando/H-6022-2015
OI Murri, Mora/0000-0002-6482-192X; Cardona, Fernando/0000-0003-4460-6824;
   Tinahones, Francisco J/0000-0001-6871-4403
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NR 40
TC 24
Z9 29
U1 0
U2 5
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0009-9120
EI 1873-2933
J9 CLIN BIOCHEM
JI Clin. Biochem.
PD JUN
PY 2008
VL 41
IS 9
BP 701
EP 705
DI 10.1016/j.clinbiochem.2008.03.001
PG 5
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA 306HY
UT WOS:000256240100009
PM 18371305
DA 2025-06-11
ER

PT J
AU de la Iglesia, R
   Lopez-Legarrea, P
   Celada, P
   Sánchez-Muniz, FJ
   Martinez, JA
   Zulet, MA
AF de la Iglesia, Rocio
   Lopez-Legarrea, Patricia
   Celada, Paloma
   Sanchez-Muniz, Francisco J.
   Alfredo Martinez, J.
   Angeles Zulet, M.
TI Beneficial Effects of the RESMENA Dietary Pattern on Oxidative Stress in
   Patients Suffering from Metabolic Syndrome with Hyperglycemia Are
   Associated to Dietary TAC and Fruit Consumption
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE metabolic syndrome; hyperglycemia; oxidative stress; TAC; fruit
ID DENSITY-LIPOPROTEIN; WEIGHT-LOSS; ARYLESTERASE ACTIVITY;
   DIABETIC-PATIENTS; RENAL-FUNCTION; RISK-FACTORS; BODY-WEIGHT;
   FATTY-ACIDS; URIC-ACID; PLASMA
AB Hyperglycemia and oxidative stress are conditions directly related to the metabolic syndrome (MetS), whose prevalence is increasing worldwide. This study aimed to evaluate the effectiveness of a new weight-loss dietary pattern on improving the oxidative stress status on patients suffering MetS with hyperglycemia. Seventy-nine volunteers were randomly assigned to two low-calorie diets (-30% Energy): the control diet based on the American Health Association criteria and the RESMENA diet based on a different macronutrient distribution (30% proteins, 30% lipids, 40% carbohydrates), which was characterized by an increase of the meal frequency (seven-times/day), low glycemic load, high antioxidant capacity (TAC) and high n-3 fatty acids content. Dietary records, anthropometrical measurements, biochemical parameters and oxidative stress biomarkers were analyzed before and after the six-month-long study. The RESMENA (Metabolic Syndrome Reduction in Navarra) diet specifically reduced the android fat mass and demonstrated more effectiveness on improving general oxidative stress through a greater decrease of oxidized LDL (oxLDL) values and protection against arylesterase depletion. Interestingly, oxLDL values were associated with dietary TAC and fruit consumption and with changes on body mass index (BMI), waist circumference, fat mass and triacilglyceride (TG) levels. In conclusion, the antioxidant properties of the RESMENA diet provide further benefits to those attributable to weight loss on patients suffering Mets with hyperglycemia.
C1 [de la Iglesia, Rocio; Lopez-Legarrea, Patricia; Alfredo Martinez, J.; Angeles Zulet, M.] Univ Navarra, Dept Nutr Food Sci & Physiol, Pamplona 31008, Spain.
   [Celada, Paloma; Sanchez-Muniz, Francisco J.] Univ Complutense Madrid, Dept Nutr & Bromatol, E-28040 Madrid, Spain.
   [Alfredo Martinez, J.; Angeles Zulet, M.] Ctr Biomed Res Network, CIBERobn Physiopathol Obes & Nutr, Madrid 29029, Spain.
C3 University of Navarra; Complutense University of Madrid; CIBER - Centro
   de Investigacion Biomedica en Red; CIBEROBN
RP Martinez, JA (corresponding author), Univ Navarra, Dept Nutr Food Sci & Physiol, Pamplona 31008, Spain.
EM rdelaiglesi@alumni.unav.es; pllegarrea@alumni.unav.es; pcelada@ucm.es;
   frasan@farm.ucm.es; jalfmtz@unav.es; mazulet@unav.es
RI de la Iglesia, Rocio/ABC-6189-2020; Sanchez-Muniz, Francisco
   J/K-9795-2014; Martinez Hernandez, J Alfredo/K-8709-2014; Zulet, M.
   Angeles/H-1317-2017
OI Sanchez-Muniz, Francisco J/0000-0002-2660-5126; Martinez Hernandez, J
   Alfredo/0000-0001-5218-6941; Celada Rodriguez,
   Paloma/0009-0009-4055-3973; de la Iglesia, Rocio/0000-0002-7472-3565;
   Zulet, M. Angeles/0000-0002-3926-0892
FU Health Department of the Government of Navarra [48/2009]; Linea Especial
   about Nutrition, Obesity and Health (University of Navarra) [LE/97];
   CIBERobn scheme; RETICS scheme; Carlos III Health Institute [FI10/00587]
FX The present work was supported by the Health Department of the
   Government of Navarra (48/2009) and the Linea Especial about Nutrition,
   Obesity and Health (University of Navarra LE/97). The support from
   CIBERobn and RETICS schemes is gratefully accredited. The authors thank
   the volunteers for taking part in this study and the physician Blanca E.
   Martinez de Morentin, the nurse Salome Perez and the technician Veronica
   Ciaurriz for excellent technical assistance at the Metabolic Unit of the
   University of Navarra. Carlos III Health Institute provided a
   predoctoral grant to R. de la Iglesia (no FI10/00587).
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NR 66
TC 34
Z9 35
U1 0
U2 16
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD APR
PY 2013
VL 14
IS 4
BP 6903
EP 6919
DI 10.3390/ijms14046903
PG 17
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 131SU
UT WOS:000318017100019
PM 23535332
OA Green Published, gold, Green Submitted, Green Accepted
DA 2025-06-11
ER

PT J
AU Giglio, RV
   Stoian, AP
   Al-Rasadi, K
   Banach, M
   Patti, AM
   Ciaccio, M
   Rizvi, AA
   Rizzo, M
AF Giglio, Rosaria Vincenza
   Pantea Stoian, Anca
   Al-Rasadi, Khalid
   Banach, Maciej
   Patti, Angelo Maria
   Ciaccio, Marcello
   Rizvi, Ali A.
   Rizzo, Manfredi
TI Novel Therapeutical Approaches to Managing Atherosclerotic Risk
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE atherosclerosis; inflammations; oxidative stress; innovative therapies;
   nutraceuticals; molecular signaling; management
ID DEPENDENT INSULINOTROPIC POLYPEPTIDE; PLASMA LIPOPROTEIN(A)
   CONCENTRATIONS; GASTRIC-INHIBITORY POLYPEPTIDE; SMOOTH-MUSCLE-CELLS;
   METABOLIC SYNDROME; ATHEROGENIC DYSLIPIDEMIA; ENDOTHELIAL DYSFUNCTION;
   CEREBROVASCULAR EVENTS; LIPID-METABOLISM; GENE-EXPRESSION
AB Atherosclerosis is a multifactorial vascular disease that leads to inflammation and stiffening of the arteries and decreases their elasticity due to the accumulation of calcium, small dense Low Density Lipoproteins (sdLDL), inflammatory cells, and fibrotic material. A review of studies pertaining to cardiometabolic risk factors, lipids alterations, hypolipidemic agents, nutraceuticals, hypoglycaemic drugs, atherosclerosis, endothelial dysfunction, and inflammation was performed. There are several therapeutic strategies including Proprotein Convertase Subtilisin/Kexin 9 (PCSK9) inhibitors, inclisiran, bempedoic acid, Glucagon-Like Peptide-1 Receptor agonists (GLP-1 RAs), and nutraceuticals that promise improvement in the atheromatous plaque from a molecular point of view, because have actions on the exposure of the LDL-Receptor (LDL-R), on endothelial dysfunction, activation of macrophages, on lipid oxidation, formations on foam cells, and deposition extracellular lipids. Atheroma plaque reduction both as a result of LDL-Cholesterol (LDL-C) intensive lowering and reducing inflammation and other residual risk factors is an integral part of the management of atherosclerotic disease, and the use of valid therapeutic alternatives appear to be appealing avenues to solving the problem.
C1 [Giglio, Rosaria Vincenza; Ciaccio, Marcello] Univ Palermo, Inst Clin Biochem Clin Mol Med & Lab Med, Dept Biomed Neurosci & Adv Diagnost, I-90127 Palermo, Italy.
   [Pantea Stoian, Anca; Rizzo, Manfredi] Carol Davila Univ, Fac Gen Med, Diabet Nutr & Metab Dis Dept, Bucharest 050474, Romania.
   [Al-Rasadi, Khalid] Sultan Qaboos Univ, Med Res Ctr, Muscat 123, Oman.
   [Banach, Maciej] Med Univ Lodz, Dept Hypertens, Chair Nephrol & Hypertens, PL-90419 Lodz, Poland.
   [Banach, Maciej] Polish Mothers Mem Hosp Res Inst, PL-93338 Lodz, Poland.
   [Banach, Maciej] Univ Zielona Gora, Cardiovasc Res Ctr, PL-65417 Zielona Gora, Poland.
   [Patti, Angelo Maria; Rizzo, Manfredi] Univ Palermo, Dept Hlth Promot Mother & Child Care Internal Med, I-90133 Palermo, Italy.
   [Ciaccio, Marcello] Univ Hosp, Dept Lab Med, I-90127 Palermo, Italy.
   [Rizvi, Ali A.] Emory Univ, Dept Med, Div Endocrinol Metab & Lipids, Atlanta, GA 30322 USA.
   [Rizvi, Ali A.; Rizzo, Manfredi] Univ South Carolina, Sch Med, Div Endocrinol Diabet & Metab, Columbia, SC 29208 USA.
C3 University of Palermo; Carol Davila University of Medicine & Pharmacy;
   Sultan Qaboos University; Medical University Lodz; Polish Mother's
   Memorial Hospital - Research Institute; University of Zielona Gora;
   University of Palermo; Emory University; University of South Carolina
   System; University of South Carolina Columbia
RP Patti, AM (corresponding author), Univ Palermo, Dept Hlth Promot Mother & Child Care Internal Med, I-90133 Palermo, Italy.
EM rosaria.vincenza.giglio@alice.it; anca.stoian@umfcd.ro;
   k.alrasadi@gmail.com; maciej.banach@umed.lodz.pl;
   angelomaria.patti@unipa.it; marcello.ciaccio@unipa.it;
   ali.abbas.rizvi@emory.edu; manfredi.rizzo@unipa.it
RI GIGLIO, Rosaria Vincenza/IAR-9444-2023; Al-Rasadi, Khalid/ABB-7852-2020;
   RIZZO, MANFREDI/GZL-0551-2022; Rizvi, Ali/AFV-2240-2022; Banach,
   Maciej/A-1271-2009; Pantea Stoian, Anca/H-5799-2017
OI GIGLIO, Rosaria Vincenza/0000-0002-7968-1480; Pantea Stoian,
   Anca/0000-0003-0555-526X; Rizvi, Ali/0000-0002-3714-0790; RIZZO,
   Manfredi/0000-0002-9549-8504; Ciaccio, Marcello/0000-0001-6120-9041
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NR 137
TC 41
Z9 43
U1 0
U2 10
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD MAY
PY 2021
VL 22
IS 9
AR 4633
DI 10.3390/ijms22094633
PG 18
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA SC1KQ
UT WOS:000650439800001
PM 33924893
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Zakaria, Z
   Othman, ZA
   Suleiman, JB
   Jalil, NAC
   Ghazali, WSW
   Mohamed, M
AF Zakaria, Zaida
   Othman, Zaidatul Akmal
   Suleiman, Joseph Bagi
   Jalil, Nur Asyilla Che
   Ghazali, Wan Syaheedah Wan
   Mohamed, Mahaneem
TI Protective and Therapeutic Effects of Orlistat on Metabolic Syndrome and
   Oxidative Stress in High-Fat Diet-Induced Metabolic
   Dysfunction-Associated Fatty Liver Disease (MAFLD) in Rats: Role on Nrf2
   Activation
SO VETERINARY SCIENCES
LA English
DT Article
DE Keap1; metabolic syndrome; NAFLD; Nrf2; orlistat; oxidative stress
   parameters
ID INSULIN-RESISTANCE; HEPATIC STEATOSIS; PLASMA-LIPIDS; OBESITY;
   METAANALYSIS; STEATOHEPATITIS; INFLAMMATION; PATHOGENESIS; ADIPONECTIN;
   COMBINATION
AB Metabolic dysfunction-associated fatty liver disease (MAFLD) is an excessive buildup of liver lipids closely associated with various kinds of undesirable metabolic effects and oxidative stress. We aimed to investigate the protective and therapeutic effects of orlistat on metabolic syndrome and oxidative stress parameters in high-fat diet (HFD) induced-MAFLD rats. Twenty-four male Sprague-Dawley rats were randomly divided into four groups (n = 6/group), i.e., Normal control (N), HFD, HFD + orlistat (HFD + O) (10 mg/kg/day administered concomitantly for 12 weeks as a protective model), and obese+orlistat (OB + O) (10 mg/kg/day administered 6 weeks after induction of obesity as a therapeutic model) groups. After 12 weeks, the HFD group had significantly increased Lee obesity index, serum alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, total cholesterol, triglyceride, low-density lipoprotein levels, liver total cholesterol and triglyceride levels, insulin resistance and non-alcoholic steatohepatitis (NASH) together with decreased serum high-density lipoprotein level. Additionally, the HFD group also showed increased Nrf2 translocation to the nucleus with high Keap1 expression and increased liver oxidative stress parameters. Orlistat significantly improved all these alterations in HFD rats. We demonstrated that orlistat might have protective and therapeutic effects against HFD-induced MAFLD rats by its activation on Nrf2 signaling pathway, which subsequently improved metabolic syndrome and oxidative stress parameters.
C1 [Zakaria, Zaida; Othman, Zaidatul Akmal; Ghazali, Wan Syaheedah Wan; Mohamed, Mahaneem] Univ Sains Malaysia, Sch Med Sci, Dept Physiol, Kubang Kerian 16150, Kelantan, Malaysia.
   [Othman, Zaidatul Akmal] Univ Sultan Zainal Abidin, Unit Physiol, Kuala Terengganu 20400, Malaysia.
   [Suleiman, Joseph Bagi] Dept Sci Lab Technol, Akanu Ibiam Fed Polytech, PMB 1007, Unwana 1007, Ebonyi State, Nigeria.
   [Jalil, Nur Asyilla Che] Univ Sains Malaysia, Sch Med Sci, Dept Pathol, Kubang Kerian 16150, Kelantan, Malaysia.
   [Mohamed, Mahaneem] Univ Sains Malaysia, Sch Med Sci, Unit Integrat Med, Kubang Kerian 16150, Kelantan, Malaysia.
C3 Universiti Sains Malaysia; Universiti Sultan Zainal Abidin; Universiti
   Sains Malaysia; Universiti Sains Malaysia
RP Mohamed, M (corresponding author), Univ Sains Malaysia, Sch Med Sci, Dept Physiol, Kubang Kerian 16150, Kelantan, Malaysia.; Mohamed, M (corresponding author), Univ Sains Malaysia, Sch Med Sci, Unit Integrat Med, Kubang Kerian 16150, Kelantan, Malaysia.
EM zakaria@student.usm.my; zaidaakmal@unisza.edu.my;
   bagisuleiman@student.usm.my; asyilla@usm.my; syaheeda@usm.my;
   mahaneem@usm.my
RI suleiman, joesph bagi/HTN-7580-2023; Wan Ghazali, Wan
   Syamimee/ISV-4326-2023; Othman, Zaidatul/ABA-8283-2021; Jalil,
   Nur/D-8544-2017; ZAKARIA, ZAIDA/H-3951-2016; Mohamed,
   Mahaneem/F-1159-2011; suleiman, joseph bagi/Q-3559-2018
OI ZAKARIA, ZAIDA/0000-0002-4138-4747; Othman, Zaidatul
   Akmal/0000-0002-9442-8563; Mohamed, Mahaneem/0000-0001-9333-1957;
   suleiman, joseph bagi/0000-0002-0629-7621; Che Jalil, Nur Asyilla Che
   Jalil/0000-0001-5871-2295
FU GIPS-PhD grant from Universiti Sains Malaysia [311/PPSP/4404813]
FX This study was financially supported by GIPS-PhD grant from Universiti
   Sains Malaysia (311/PPSP/4404813).
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NR 103
TC 18
Z9 19
U1 2
U2 10
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2306-7381
J9 VET SCI
JI Vet. Sci.
PD NOV
PY 2021
VL 8
IS 11
AR 274
DI 10.3390/vetsci8110274
PG 21
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA 1X1EL
UT WOS:000807205300001
PM 34822647
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Gagliardi, L
   Ho, JT
   Torpy, DJ
AF Gagliardi, Lucia
   Ho, Jui T.
   Torpy, David J.
TI Corticosteroid-binding globulin: The clinical significance of altered
   levels and heritable mutations
SO MOLECULAR AND CELLULAR ENDOCRINOLOGY
LA English
DT Review
DE Corticosteroid-binding globulin; CBG Lyon; CBG null; CBG Leuven;
   Fatigue; Cortisol
ID CHRONIC-FATIGUE-SYNDROME; HORMONE REPLACEMENT THERAPY;
   INSULIN-RESISTANCE SYNDROME; PITUITARY-ADRENAL AXIS; HEP G2 CELLS;
   CORTISOL-BINDING; SEPTIC SHOCK; STEROID-BINDING; PLASMA-CORTISOL; HUMAN
   TRANSCORTIN
AB Corticosteroid-binding globulin (CBG) is the specific high-affinity plasma transport glycoprotein for cortisol. Stress-induced falls in CBG levels may heighten hypothalamic-pituitary-adrenal axis responses and CBG:tissue interactions may allow targeted cortisol delivery. Three genetic variants of CBG have been identified that reduce cortisol binding affinity and/or CBG levels. These include the Leuven and Lyon mutations which reduce CBG:cortisol binding affinity 3- and 4-fold, respectively, and the null mutation resulting in a 50% (heterozygote) or 100% (homozygote) reduction in CBG levels. The three reported null homozygotes demonstrate that complete CBG deficiency is not lethal, although it may be associated with hypotension and fatigue. The phenotype of a CBG null murine model included fatigue and immune defects. One community-based study revealed that severe CBG mutations are rare in idiopathic fatigue disorders. The mechanisms by which CBG mutations may cause fatigue are unknown. There are preliminary data of altered CBG levels in hypertension and in the metabolic syndrome; however, the nature of these associations is uncertain. Further studies may clarify the functions of CBG, and clinical observations may validate and/or extend the phenotypic features of various CBG mutations. Crown Copyright (C) 2009 Published by Elsevier Ireland Ltd. All rights reserved.
C1 [Gagliardi, Lucia; Ho, Jui T.; Torpy, David J.] Royal Adelaide Hosp, Endocrine & Metab Unit, Adelaide, SA 5000, Australia.
   [Gagliardi, Lucia; Torpy, David J.] Univ Adelaide, Sch Med, Adelaide, SA 5005, Australia.
C3 Royal Adelaide Hospital; University of Adelaide
RP Torpy, DJ (corresponding author), Royal Adelaide Hosp, Endocrine & Metab Unit, Level 7,Emergency Block, Adelaide, SA 5000, Australia.
EM david.torpy@health.sa.gov.au
RI wittert, gary/AAE-2398-2019
OI Torpy, David/0000-0002-5069-0981
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NR 126
TC 66
Z9 73
U1 0
U2 8
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0303-7207
J9 MOL CELL ENDOCRINOL
JI Mol. Cell. Endocrinol.
PD MAR 5
PY 2010
VL 316
IS 1
SI SI
BP 24
EP 34
DI 10.1016/j.mce.2009.07.015
PG 11
WC Cell Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Endocrinology & Metabolism
GA 553LR
UT WOS:000274368700004
PM 19643166
DA 2025-06-11
ER

PT J
AU Choi, KW
   Na, EJ
   Fava, M
   Mischoulon, D
   Cho, H
   Jeon, HJ
AF Choi, Kwan Woo
   Na, Eun Jin
   Fava, Maurizio
   Mischoulon, David
   Cho, Hana
   Jeon, Hong Jin
TI Increased adrenocorticotropic hormone (ACTH) levels predict severity of
   depression after six months of follow-up in outpatients with major
   depressive disorder
SO PSYCHIATRY RESEARCH
LA English
DT Article
DE ACTH; Adrenocorticotropic hormone; HPA axis; Major depressive disorder;
   Patient Health Questionnaire; PHQ-9
ID CORTICOTROPIN-RELEASING HORMONE; CORTISOL AWAKENING RESPONSE; KOREAN
   MEDICATION ALGORITHM; METABOLIC SYNDROME; AXIS ACTIVITY; HPA-AXIS;
   ANTIDEPRESSANT RESPONSE; NEUROTROPHIC FACTOR; RESIDUAL SYMPTOMS;
   CUSHINGS-SYNDROME
AB Previous studies have reported dysfunction in the hypothalamic-pituitary-adrenal (HPA) axis in patients with major depressive disorder (MDD). Outpatients diagnosed with MDD (n = 199) underwent psychological evaluation, and were followed up with a phone interview after 6 months, using the Patient Health Questionnaire (PHQ-9). At 6-month follow-up, 59 out of 199 patients with MDD were still depressed (29.5%), as shown by scores >= 10 on the PHQ-9. The depressed group at follow-up showed significantly higher anxiety and suicidality levels at baseline than the non-depressed group at follow-up. Among the complete blood counts, lipid profiles, and hormone levels, adrenocorticotropic hormone (ACTH) was the only parameter that was significantly increased in the still depressed group. Levels higher than 40 pg/mL of ACTH at baseline were associated with higher depression scores at follow-up. Multiple linear regression analyses revealed that ACTH and cortisol predicted depression scores at follow-up, after controlling for baseline depression scores. Increased ACTH level at baseline may predict ongoing symptoms and severity of depression at follow-up, suggesting the role of dysfunctional HPA axis in MDD prognosis.
C1 [Choi, Kwan Woo; Na, Eun Jin; Jeon, Hong Jin] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Psychiat,Depress Ctr, Seoul, South Korea.
   [Fava, Maurizio; Mischoulon, David] Harvard Med Sch, Massachusetts Gen Hosp, Depress Clin & Res Program, Boston, MA USA.
   [Cho, Hana] Sungkyunkwan Univ, Sch Med, Samsung Biomed Res Inst, Dept Physiol, Suwon 440746, South Korea.
   [Jeon, Hong Jin] Sungkyunkwan Univ, SAIHST, Dept Hlth Sci & Technol, Dept Med Device Management & Res, Seoul, South Korea.
   [Jeon, Hong Jin] Sungkyunkwan Univ, SAIHST, Dept Clin Res Design & Evaluat, Seoul, South Korea.
C3 Sungkyunkwan University (SKKU); Samsung Medical Center; Harvard
   University; Harvard Medical School; Harvard University Medical
   Affiliates; Massachusetts General Hospital; Sungkyunkwan University
   (SKKU); Sungkyunkwan University (SKKU); Sungkyunkwan University (SKKU)
RP Jeon, HJ (corresponding author), Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Psychiat,Depress Ctr, Seoul, South Korea.
EM jeonhj@skku.edu
RI Fava, Maurizio/AAH-3548-2020; Mischoulon, David/D-7500-2016
OI Choi, Kwan Woo/0000-0002-0854-3507; Cho, Hana/0000-0002-9394-8671
FU Original Technology Research Program for Brain Science through the
   National Research Foundation of Korea (NRF) - Ministry of Education,
   Science and Technology [NRF-2016M3C7A1947307]; Bio & Medical Technology
   Development Program of the NRF - Korean government, MSIP
   [NRF-2017M3A9F1027323]; Samsung Medical Center grant [SMO1161491]
FX This research was supported by the Original Technology Research Program
   for Brain Science through the National Research Foundation of Korea
   (NRF) funded by the Ministry of Education, Science and Technology (No.
   NRF-2016M3C7A1947307; PI HJJ), and the Bio & Medical Technology
   Development Program of the NRF funded by the Korean government, MSIP
   (No. NRF-2017M3A9F1027323; PI HJJ). This study was also supported by
   Samsung Medical Center grant (SMO1161491, PI HJJ).
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NR 86
TC 33
Z9 38
U1 0
U2 11
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0165-1781
EI 1872-7123
J9 PSYCHIAT RES
JI Psychiatry Res.
PD DEC
PY 2018
VL 270
BP 246
EP 252
DI 10.1016/j.psychres.2018.09.047
PG 7
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA HG4VH
UT WOS:000454972600034
PM 30269042
DA 2025-06-11
ER

PT J
AU Magnavita, N
   Di Prinzio, RR
   Arnesano, G
   Cerrina, A
   Gabriele, M
   Garbarino, S
   Gasbarri, M
   Iuliano, A
   Labella, M
   Matera, C
   Mauro, I
   Barbic, F
AF Magnavita, Nicola
   Di Prinzio, Reparata Rosa
   Arnesano, Gabriele
   Cerrina, Anna
   Gabriele, Maddalena
   Garbarino, Sergio
   Gasbarri, Martina
   Iuliano, Angela
   Labella, Marcella
   Matera, Carmela
   Mauro, Igor
   Barbic, Franca
TI Association of Occupational Distress and Low Sleep Quality with Syncope,
   Presyncope, and Falls in Workers
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Article
DE loss of consciousness; mental health; working life; effort reward
   imbalance; sleep dis-orders; health promotion; workplace
ID GENERAL HEALTH QUESTIONNAIRE; OF-LIFE; VASOVAGAL SYNCOPE; MANAGEMENT;
   RISK; GUIDELINES; VERSION; ACC/AHA/HRS; RECURRENCE; DIAGNOSIS
AB Syncope and presyncope episodes that occur during work could affect one's safety and impair occupational performance. Few data are available regarding the prevalence of these events among workers. The possible role of sleep quality, mental stress, and metabolic disorders in promoting syncope, presyncope, and falls in workers is unknown. In the present study, 741 workers (male 35.4%; mean age 47 +/- 11 years), employed at different companies, underwent clinical evaluation and blood tests, and completed questionnaires to assess sleep quality, occupational distress, and mental disorders. The occurrence of syncope, presyncope, and unexplained falls during working life was assessed via an ad hoc interview. The prevalence of syncope, presyncope, and falls of unknown origin was 13.9%, 27.0%, and 10.3%, respectively. The occurrence of syncope was associated with an increased risk of occupational distress (adjusted odds ratio aOR: 1.62, confidence intervals at 95%: 1.05-2.52), low sleep quality (aOR: 1.79 CI 95%: 1.16-2.77), and poor mental health (aOR: 2.43 CI 95%: 1.52-3.87). Presyncope was strongly associated with occupational distress (aOR: 1.77 CI 95%: 1.25-2.49), low sleep quality (aOR: 2.95 CI 95%: 2.08-4.18), and poor mental health (aOR: 2.61 CI 95%: 1.78-3.84), while no significant relationship was found between syncope or presyncope and metabolic syndrome. These results suggest that occupational health promotion interventions aimed at improving sleep quality, reducing stressors, and increasing worker resilience might reduce syncope and presyncope events in the working population.
C1 [Magnavita, Nicola; Di Prinzio, Reparata Rosa; Arnesano, Gabriele; Garbarino, Sergio; Iuliano, Angela; Mauro, Igor; Barbic, Franca] Univ Cattolica Sacro Cuore, Postgrad Sch Occupat Hlth, I-00168 Rome, Italy.
   [Magnavita, Nicola] Fdn Policlin Univ A Gemelli IRCCS, Dept Woman Child & Publ Hlth Sci, I-00168 Rome, Italy.
   [Magnavita, Nicola; Cerrina, Anna; Gabriele, Maddalena; Gasbarri, Martina; Labella, Marcella; Matera, Carmela] Local Sanit Unit Roma4, I-00053 Civitavecchia, Italy.
   [Garbarino, Sergio] Dept Neurosci Rehabil Ophthalmol Genet & Maternal, I-16132 Genoa, Italy.
   [Barbic, Franca] Humanitas Univ, Dept Biomed Sci, I-20072 Pieve Emanuele, Italy.
   [Barbic, Franca] IRCCS Humanitas Res Hosp, Internal Med, I-20089 Rozzano, Italy.
C3 Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli;
   Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli;
   Humanitas University
RP Magnavita, N (corresponding author), Univ Cattolica Sacro Cuore, Postgrad Sch Occupat Hlth, I-00168 Rome, Italy.; Magnavita, N (corresponding author), Fdn Policlin Univ A Gemelli IRCCS, Dept Woman Child & Publ Hlth Sci, I-00168 Rome, Italy.; Magnavita, N (corresponding author), Local Sanit Unit Roma4, I-00053 Civitavecchia, Italy.
EM nicolamagnavita@gmail.com; repdip@gmail.com;
   gabrielearnesano93@gmail.com; anna.cerrina@aslroma4.it;
   maddalena.gabriele@aslroma4.it; sgarbarino.neuro@gmail.com;
   martina.gasbarri@aslroma4.it; iuliano_angela@yahoo.it;
   marcella.labella@aslroma4.it; carmela.matera@aslroma4.it;
   mau.igor91@yahoo.it; franca.barbic@hunimed.eu
RI Garbarino, Sergio/AAV-4629-2021; Magnavita, Nicola/J-6074-2014; Di
   Prinzio, Reparata Rosa/GRO-3110-2022; Garbarino, Sergio/X-5368-2018;
   Barbic, Franca/S-2183-2019
OI Garbarino, Sergio/0000-0002-8508-552X; Di Prinzio, Reparata
   Rosa/0000-0001-5956-1038; Barbic, Franca/0000-0002-8283-1988; Arnesano,
   Gabriele/0000-0001-8763-2761
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NR 63
TC 4
Z9 4
U1 0
U2 12
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD DEC
PY 2021
VL 18
IS 23
AR 12283
DI 10.3390/ijerph182312283
PG 11
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA XV8NL
UT WOS:000735191600001
PM 34886008
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Rocha, HNM
   Velasco, LL
   Batista, GMS
   Storch, AS
   Garcia, VP
   Teixeira, GF
   Mentzinger, J
   da Nóbrega, ACL
   Rocha, NG
AF Rocha, Helena N. M.
   Velasco, Larissa L.
   Batista, Gabriel M. S.
   Storch, Amanda S.
   Garcia, Vinicius P.
   Teixeira, Gabriel F.
   Mentzinger, Juliana
   da Nobrega, Antonio C. L.
   Rocha, Natalia G.
TI Ascorbic acid prevents stress-induced hypercoagulability in overweight
   and obese individuals
SO SCIENTIFIC REPORTS
LA English
DT Article
DE Coagulation; Obesity; Ascorbic acid; Mental stress; Nitric oxide
ID MENTAL STRESS; MYOCARDIAL-INFARCTION; ENDOTHELIAL DYSFUNCTION;
   PSYCHOLOGICAL STRESS; METABOLIC SYNDROME; NITRIC-OXIDE; RISK-FACTORS;
   ACTIVATION; PLATELET; HEALTHY
AB Ascorbic acid (AA) may contribute to restoring hemostatic balance after mental stress (MS) in overweight/obese adults. We aimed to determine the effects of AA administration on hemostatic responses to MS in overweight/obese men. Fourteen overweight/obesity men (27 +/- 7 years; BMI: 29.7 +/- 2.6 kg m(-2)) performed the Stroop color-word stress task for 5 min after non-simultaneous infusion of placebo (PL, 0.9% NaCl) and AA (3 g). Blood was collected at baseline, during MS, and 60 min after MS to measure: activated partial thromboplastin time, prothrombin time, and fibrinogen concentration, by coagulometer; platelet-derived microvesicles (PMV, mv/mu L), by flow cytometry; nitrite (mu M), by chemiluminescence. In PL session, MS led to decreases in PTs (stress, p = 0.03; 60 min, p < 0.001), PT-INR (stress, p < 0.001; 60 min, p < 0.01), aPTTs (60 min, p = 0.03), aPTT ratio (60 min, p = 0.04) and fibrinogen (60 min, p = 0.04), while increased PT activity (60 min, p = 0.01) when compared to baseline. Furthermore, AA increased PTs (60 min, p < 0.001), PT-INR (60 min, p = 0.03) and decreased PT activity (60 min, p < 0.001) and fibrinogen (stress, p = 0.04) when compared to PL. Nitrite was increased in response to stress during AA session (p < 0.001 vs PL). There was no difference in PMV. Ascorbic acid prevented the impaired hemostatic profile and improved nitrite response to stress in the overweight and obese adults.
C1 [Rocha, Helena N. M.; Velasco, Larissa L.; Batista, Gabriel M. S.; Storch, Amanda S.; Garcia, Vinicius P.; Teixeira, Gabriel F.; Mentzinger, Juliana; da Nobrega, Antonio C. L.; Rocha, Natalia G.] Fluminense Fed Univ, Dept Physiol & Pharmacol, Lab Exercise Sci, Rua Alameda Barros Terra,Sala 110, BR-24020150 Niteroi, RJ, Brazil.
   [Rocha, Helena N. M.; Velasco, Larissa L.; Batista, Gabriel M. S.; Storch, Amanda S.; Garcia, Vinicius P.; Teixeira, Gabriel F.; Mentzinger, Juliana; da Nobrega, Antonio C. L.; Rocha, Natalia G.] Fluminense Fed Univ, Dept Physiol & Pharmacol, Lab Integrat Cardiometabol, Rua Alameda Barros Terra,Sala 110, BR-24020141 Niteroi, RJ, Brazil.
   [Rocha, Helena N. M.; Garcia, Vinicius P.; da Nobrega, Antonio C. L.; Rocha, Natalia G.] Natl Council Sci & Technol Dev CNPq, Natl Inst Sci & Technol INCT Phys In Act & Exercis, Rua Alameda Barros Terra,Sala 110, Niteroi, RJ, Brazil.
C3 Universidade Federal Fluminense; Universidade Federal Fluminense
RP Rocha, NG (corresponding author), Fluminense Fed Univ, Dept Physiol & Pharmacol, Lab Exercise Sci, Rua Alameda Barros Terra,Sala 110, BR-24020150 Niteroi, RJ, Brazil.; Rocha, NG (corresponding author), Fluminense Fed Univ, Dept Physiol & Pharmacol, Lab Integrat Cardiometabol, Rua Alameda Barros Terra,Sala 110, BR-24020141 Niteroi, RJ, Brazil.; Rocha, NG (corresponding author), Natl Council Sci & Technol Dev CNPq, Natl Inst Sci & Technol INCT Phys In Act & Exercis, Rua Alameda Barros Terra,Sala 110, Niteroi, RJ, Brazil.
EM nataliagalito@id.uff.br
RI da Nobrega, Antonio/O-5107-2019; Rocha, Natalia/AAN-7903-2020; Pacheco
   Garcia, Vinicius/ABE-2776-2020; Rocha, Helena/B-9530-2018
OI Fernandes Teixeira, Gabriel/0000-0002-7078-1880
FU Coordenao de Aperfeioamento de Pessoal de Nvel Superior; Foundation for
   Research Support of Rio de Janeiro (FAPERJ); Coordination for the
   Improvement of Higher Education Personnel (CAPES); National Council for
   Scientific and Technological Development (CNPq)
FX The authors of the present study thank and appreciate all the time and
   efforts put into making this paper's idealization, writing and
   publication possible. We also wish to thank the staff and students that
   are part of the Laboratory of Exercise Sciences at Fluminense Federal
   University for the partnership provided as well as funding from the
   Foundation for Research Support of Rio de Janeiro (FAPERJ), the
   Coordination for the Improvement of Higher Education Personnel (CAPES)
   and National Council for Scientific and Technological Development
   (CNPq).
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NR 52
TC 0
Z9 0
U1 0
U2 1
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD FEB 7
PY 2024
VL 14
IS 1
AR 3122
DI 10.1038/s41598-024-53794-7
PG 10
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA HI7B1
UT WOS:001158921600078
PM 38326408
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Borghese, MM
   Borgundvaag, E
   McIsaac, MA
   Janssen, I
AF Borghese, M. M.
   Borgundvaag, E.
   McIsaac, M. A.
   Janssen, I.
TI Imputing accelerometer nonwear time in children influences estimates of
   sedentary time and its associations with cardiometabolic risk
SO INTERNATIONAL JOURNAL OF BEHAVIORAL NUTRITION AND PHYSICAL ACTIVITY
LA English
DT Article
DE Missing data; Multiple imputation; Accelerometer; Sedentary behaviour;
   Child; Health
ID VIGOROUS PHYSICAL-ACTIVITY; SCHOOL-AGED CHILDREN; MULTIPLE IMPUTATION;
   HEALTH INDICATORS; CANADIAN CHILDREN; METABOLIC RISK; MISSING DATA;
   LIFE-STYLE; YOUTH; MODERATE
AB BackgroundA limitation of measuring sedentary time with an accelerometer is device removal. The resulting nonwear time is typically deleted from the data prior to calculating sedentary time. This could impact estimates of sedentary time and its associations with health indicators. We evaluated whether using multiple imputation to replace nonwear accelerometer epochs influences such estimates in children.Methods452 children (50% male) aged 10-13 were tasked with wearing an accelerometer (15s epochs) for 7days. On average, 8% of waking time was classified as nonwear time. Sedentary time was derived from a nonimputed dataset using the typical approach of deleting epochs that occurred during nonwear time, as well as from an imputed dataset. In the imputed dataset, each nonwear epoch was re-classified as being as sedentary or not using multiple imputation (5 iterations) which was informed by the likelihood of a wear time epoch being classified as sedentary or not using parameter estimates from a logistic regression model. Estimates of sedentary time and associations between sedentary time and health indicators (cardiometabolic risk factor and internalizing mental health symptoms Z-scores) were compared between the nonimputed and imputed datasets.ResultsOn average, sedentary time was 33min/day higher in the imputed dataset than in the nonimputed dataset (632 vs. 599min/day). The association between sedentary time and the cardiometabolic risk factor Z-score was stronger in the imputed vs. the nonimputed dataset (=0.137 vs. =0.092 per 60min/day change, respectively). These findings were more pronounced among children who had <7days with 10h of wear time.ConclusionResearchers should consider using multiple imputation to address accelerometer nonwear time, rather than deleting it, in order to derive more unbiased estimates of sedentary time and its associations with health indicators.
C1 [Borghese, M. M.; Janssen, I.] Queens Univ, Sch Kinesiol & Hlth Studies, 28 Div St, Kingston, ON, Canada.
   [Borgundvaag, E.; McIsaac, M. A.] Queens Univ, Dept Publ Hlth Sci, 99 Univ Ave, Kingston, ON, Canada.
C3 Queens University - Canada; Queens University - Canada
RP Janssen, I (corresponding author), Queens Univ, Sch Kinesiol & Hlth Studies, 28 Div St, Kingston, ON, Canada.
EM Mborg031@gmail.com; Ian.Janssen@queensu.ca
RI Janssen, Ian/B-7700-2009
OI Janssen, Ian/0000-0003-2159-3012
FU Heart and Stroke Foundation of Canada; Canada Research Chair award
FX This project was funding by the Heart and Stroke Foundation of Canada.
   The funder did not have a role in the design of the study nor the
   collection, analysis, or interpretation of data, nor in writing the
   manuscript. IJ was supported by a Canada Research Chair award.
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NR 51
TC 5
Z9 5
U1 0
U2 6
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1479-5868
J9 INT J BEHAV NUTR PHY
JI Int. J. Behav. Nutr. Phys. Act.
PD JAN 17
PY 2019
VL 16
AR 7
DI 10.1186/s12966-019-0770-0
PG 12
WC Nutrition & Dietetics; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nutrition & Dietetics; Physiology
GA HH9CT
UT WOS:000456032400003
PM 30654817
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Viglione, L
   Short, BL
AF Viglione, Luke
   Short, Brooke L.
TI Metabolic screen and intervene: improving mental health inpatient
   metabolic monitoring
SO AUSTRALASIAN PSYCHIATRY
LA English
DT Article
DE metabolic syndrome; antipsychotic medications; inpatient; quality
   improvement; mental disorders
ID SCHIZOPHRENIA; MANAGEMENT; DISEASE; RISK
AB Objective: To assess rates of metabolic monitoring in patients prescribed antipsychotic medications in the psychiatric inpatient setting and the impact education can have regarding monitoring compliance. Method: Two identical audits were undertaken at a NSW mental health inpatient service before and after a campaign designed to educate mental health workers about the importance of metabolic monitoring. Results from both audits were compared for statistically significant improvements in monitoring rates. Results: Rates of monitoring plasma lipids increased from 21.7% to 78.8% (p< 0.01) and rates for plasma glucose increased from 20.8% to 73.7% (p< 0.01). There were no statistically significant changes in rates of monitoring body mass index (83.0% and 77.1%, respectively), waist circumference (36.8% and 43.2%, respectively) and blood pressure (99.1% and 100%, respectively). Conclusion: This study has shown that rates of metabolic monitoring in the inpatient setting can be improved with a relatively low-cost education intervention. While absolute rates remain low, outcomes suggest that it may be worthwhile trialling further modes of education and repeating this education in cycles.
C1 [Viglione, Luke; Short, Brooke L.] Cent Coast Local Hlth Dist, Gosford, NSW, Australia.
   [Short, Brooke L.] Univ Newcastle, Sch Med & Publ Hlth, Callaghan, NSW, Australia.
C3 Central Coast Local Health District; University of Newcastle
RP Short, BL (corresponding author), Gosford Hosp, POB 361, Gosford, NSW 2250, Australia.
EM brooke.short@health.nsw.gov.au
RI Viglione, Luke/JNS-0549-2023
OI Viglione, Luke/0000-0002-0882-0324
CR Brown T, 2018, INT J MENT HEALTH NU, V27, P341, DOI 10.1111/inm.12327
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   NSW Health, GUID PHYS HLTH CAR M
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NR 16
TC 3
Z9 3
U1 0
U2 1
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1039-8562
EI 1440-1665
J9 AUSTRALAS PSYCHIATRY
JI Australas. Psychiatry
PD JUN
PY 2021
VL 29
IS 3
BP 289
EP 293
AR 1039856220936147
DI 10.1177/1039856220936147
EA JUL 2020
PG 5
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA YU1MV
UT WOS:000545232600001
PM 32615781
DA 2025-06-11
ER

PT J
AU Gutiérrez-Cuevas, J
   López-Cifuentes, D
   Sandoval-Rodriguez, A
   García-Bañuelos, J
   Armendariz-Borunda, J
AF Gutierrez-Cuevas, Jorge
   Lopez-Cifuentes, Daniel
   Sandoval-Rodriguez, Ana
   Garcia-Banuelos, Jesus
   Armendariz-Borunda, Juan
TI Medicinal Plant Extracts against Cardiometabolic Risk Factors Associated
   with Obesity: Molecular Mechanisms and Therapeutic Targets
SO PHARMACEUTICALS
LA English
DT Review
DE obesity; cardiometabolic risk factors; herbs; plants; extracts;
   molecular mechanisms; therapeutic targets
ID HIGH-FAT-DIET; TEA ILEX-PARAGUARIENSIS; CORNI FRUCTUS EXTRACT;
   OPUNTIA-FICUS-INDICA; AGED GARLIC EXTRACT; YERBA MATE EXTRACT; GREEN
   TEA; OXIDATIVE STRESS; ANDROGRAPHIS-PANICULATA; HIBISCUS-SABDARIFFA
AB Obesity has increasingly become a worldwide epidemic, as demonstrated by epidemiological and clinical studies. Obesity may lead to the development of a broad spectrum of cardiovascular diseases (CVDs), such as coronary heart disease, hypertension, heart failure, cerebrovascular disease, atrial fibrillation, ventricular arrhythmias, and sudden cardiac death. In addition to hypertension, there are other cardiometabolic risk factors (CRFs) such as visceral adiposity, dyslipidemia, insulin resistance, diabetes, elevated levels of fibrinogen and C-reactive protein, and others, all of which increase the risk of CVD events. The mechanisms involved between obesity and CVD mainly include insulin resistance, oxidative stress, inflammation, and adipokine dysregulation, which cause maladaptive structural and functional alterations of the heart, particularly left-ventricular remodeling and diastolic dysfunction. Natural products of plants provide a diversity of nutrients and different bioactive compounds, including phenolics, flavonoids, terpenoids, carotenoids, anthocyanins, vitamins, minerals, fibers, and others, which possess a wide range of biological activities including antihypertensive, antilipidemic, antidiabetic, and other activities, thus conferring cardiometabolic benefits. In this review, we discuss the main therapeutic interventions using extracts from herbs and plants in preclinical and clinical trials with protective properties targeting CRFs. Molecular mechanisms and therapeutic targets of herb and plant extracts for the prevention and treatment of CRFs are also reviewed.
C1 [Gutierrez-Cuevas, Jorge; Lopez-Cifuentes, Daniel; Sandoval-Rodriguez, Ana; Garcia-Banuelos, Jesus; Armendariz-Borunda, Juan] Univ Guadalajara, Univ Ctr Hlth Sci, Inst Mol Biol Med & Gene Therapy, Dept Mol Biol & Genom, Guadalajara 44340, Jalisco, Mexico.
   [Lopez-Cifuentes, Daniel] Univ Guadalajara, Univ Ctr Hlth Sci, Doctorate Sci Mol Biol Med, Guadalajara 44340, Jalisco, Mexico.
   [Armendariz-Borunda, Juan] Tecnol Monterrey, Escuela Med & Ciencias Salud EMCS, Campus Guadalajara, Zapopan 45201, Jalisco, Mexico.
C3 Universidad de Guadalajara; Universidad de Guadalajara; Tecnologico de
   Monterrey
RP Gutiérrez-Cuevas, J (corresponding author), Univ Guadalajara, Univ Ctr Hlth Sci, Inst Mol Biol Med & Gene Therapy, Dept Mol Biol & Genom, Guadalajara 44340, Jalisco, Mexico.
EM gutierrezcj05@gmail.com; daniel.2cifuentes@gmail.com;
   anasol44@hotmail.com; armdbo@gmail.com
RI Armendáriz-Borunda, Juan/AAU-1471-2021; Sandoval-Rodriguez,
   Ana/AFA-1796-2022
OI Garcia-Banuelos, Jesus/0000-0003-3430-9391; Armendariz-Borunda,
   Juan/0000-0002-7101-9943; Sandoval-Rodriguez, Ana/0000-0003-1708-1495;
   Gutierrez-Cuevas, Jorge/0000-0003-0276-0428
FU Consejo Nacional de Humanidades, Ciencias y Tecnologias(CONAHCYT),
   Mexico [CF-2023-I-473]
FX This work was supported by Consejo Nacional de Humanidades, Ciencias y
   Tecnologias(CONAHCYT), Mexico, under grant CF-2023-I-473 to J.G.-C
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NR 199
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PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1424-8247
J9 PHARMACEUTICALS-BASE
JI Pharmaceuticals
PD JUL
PY 2024
VL 17
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AR 967
DI 10.3390/ph17070967
PG 54
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
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PM 39065815
OA gold
DA 2025-06-11
ER

PT J
AU Sial, OK
   Gnecco, T
   Cardona-Acosta, AM
   Vieregg, E
   Cardoso, EA
   Parise, LF
   Bolaños-Guzmán, CA
AF Sial, Omar K.
   Gnecco, Tamara
   Cardona-Acosta, Astrid M.
   Vieregg, Emily
   Cardoso, Ernesto A.
   Parise, Lyonna F.
   Bolanos-Guzman, Carlos A.
TI Exposure to Vicarious Social Defeat Stress and Western-Style Diets
   During Adolescence Leads to Physiological Dysregulation, Decreases in
   Reward Sensitivity, and Reduced Antidepressant Efficacy in Adulthood
SO FRONTIERS IN NEUROSCIENCE
LA English
DT Article
DE adolescence; early-life stress; western-style; high-fat diet;
   depression; antidepressant efficacy
ID HIGH-FAT DIET; TREATMENT-RESISTANT DEPRESSION; METABOLIC SYNDROME;
   ACETYLSALICYLIC-ACID; FOOD-INTAKE; NUCLEUS-ACCUMBENS; MENTAL-DISORDERS;
   BODY-WEIGHT; OBESITY; DOPAMINE
AB A dramatic increase in the prevalence of major depression and diet-related disorders in adolescents has been observed over several decades, yet the mechanisms underlying this comorbidity have only recently begun to be elucidated. Exposure to western-style diet (WSD), high in both fats (45% kcal) and carbohydrates (35% kcal): e.g., high fat diet (HFD), has been linked to the development of metabolic syndrome-like symptoms and behavioral dysregulation in rodents, as similarly observed in the human condition. Because adolescence is a developmental period highlighted by vulnerability to both stress and poor diet, understanding the mechanism(s) underlying the combined negative effects of WSDs and stress on mood and reward regulation is critical. To this end, adolescent male C57 mice were exposed to vicarious social defeat stress (VSDS), a stress paradigm capable of separating physical (PS) versus psychological/emotional (ES) stress, followed by normal chow (NC), HFD, or a separate control diet high in carbohydrates (same sucrose content as HFD) and low in fat (LFD), while measuring body weight and food intake. Non-stressed control mice exposed to 5 weeks of NC or HFD showed no significant differences in body weight or social interaction. Mice exposed to VSDS (both ES and PS) gain weight rapidly 1 week after initiation of HFD, with the ES-exposed mice showing significantly higher weight gain as compared to the HFD-exposed control mice. These mice also exhibited a reduction in saccharin preference, indicative of anhedonic-like behavior. To further delineate whether high fat was the major contributing factor to these deficits, LFD was introduced. The mice in the VSDS + HFD gained weight more rapidly than the VSDS + LFD group, and though the LFD-exposed mice did not gain weight as rapidly as the HFD-exposed mice, both the VSDS + LFD- and VSDS + HFD-exposed mice exhibited attenuated response to the antidepressant fluoxetine. These data show that diets high in both fats and carbohydrates are responsible for rapid weight gain and reduced reward sensitivity; and that while consumption of diet high in carbohydrate and low in fat does not lead to rapid weight gain, both HFD and LFD exposure after stress leads to reduced responsiveness to antidepressant treatment.
C1 [Sial, Omar K.; Gnecco, Tamara; Cardona-Acosta, Astrid M.; Vieregg, Emily; Cardoso, Ernesto A.; Bolanos-Guzman, Carlos A.] Texas A&M Univ, Dept Psychol & Brain Sci, College Stn, TX 77843 USA.
   [Sial, Omar K.; Gnecco, Tamara; Cardona-Acosta, Astrid M.; Vieregg, Emily; Cardoso, Ernesto A.; Bolanos-Guzman, Carlos A.] Texas A&M Univ, Inst Neurosci, College Stn, TX 77843 USA.
   [Parise, Lyonna F.] Icahn Sch Med Mt Sinai, Fishberg Dept Neurosci, New York, NY 10029 USA.
C3 Texas A&M University System; Texas A&M University College Station; Texas
   A&M University System; Texas A&M University College Station; Icahn
   School of Medicine at Mount Sinai
RP Bolaños-Guzmán, CA (corresponding author), Texas A&M Univ, Dept Psychol & Brain Sci, College Stn, TX 77843 USA.; Bolaños-Guzmán, CA (corresponding author), Texas A&M Univ, Inst Neurosci, College Stn, TX 77843 USA.
EM bolanos@tamu.edu
RI Sial, Omar/AGZ-6932-2022; Bolanos-Guzman, Carlos/AAU-2853-2020
OI Sial, Omar/0000-0002-1415-572X
FU Texas A&M University, College of Liberal Arts; National Institute on
   Drug Abuse (NIDA) [R01DA046794]; NIDA; Office of Graduate and
   Professional Studies (OGAPS) at Texas AM University
FX This work was supported by Texas A&M University, College of Liberal
   Arts, and by R01DA046794 from the National Institute on Drug Abuse
   (NIDA). OS was supported by NIDA. EC was supported by a Graduate
   Diversity Excellence Fellowship provide by the Office of Graduate and
   Professional Studies (OGAPS) at Texas A&M University.
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NR 120
TC 12
Z9 13
U1 0
U2 6
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1662-453X
J9 FRONT NEUROSCI-SWITZ
JI Front. Neurosci.
PD AUG 2
PY 2021
VL 15
AR 701919
DI 10.3389/fnins.2021.701919
PG 16
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology
GA UI9LB
UT WOS:000690917800001
PM 34408623
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Garcia, ME
   Schillinger, D
   Vittinghoff, E
   Creasman, JM
   Knapp, P
   Newcomer, JW
   Mangurian, C
AF Garcia, Maria E.
   Schillinger, Dean
   Vittinghoff, Eric
   Creasman, Jennifer M.
   Knapp, Penelope
   Newcomer, John W.
   Mangurian, Christina
TI Nonpsychiatric Outpatient Care for Adults With Serious Mental Illness in
   California: Who Is Being Left Behind?
SO PSYCHIATRIC SERVICES
LA English
DT Article
ID METABOLIC SYNDROME; HEALTH-CARE; UNDERSERVED ADULTS; SERVICES; PEOPLE;
   RISK; SCHIZOPHRENIA; INDIVIDUALS
AB Objective: Although primary care is associated with better outcomes, many individuals with serious mental illness do not receive general medical services. This study examined patient-level factors associated with not having outpatient general medical visits among individuals with serious mental illness in California.
   Methods: The study analyzed administrative, pharmacy, and billing data for 56,895 Medicaid-enrolled adults with serious mental illness treated in community mental health clinics between October 1, 2010, and September 20, 2011. Poisson regression estimated independent associations between predictor variables and outpatient general medical visits.
   Results: One-third of participants (34%) had no outpatient general medical visits during the study. In multivariate analyses, younger adults (ages 18-27) were less likely than older groups to have such a visit (adjusted relative risk [ARR]=1.07 and 1.19, respectively, for ages 28-47 and 48-67). Women were more likely than men to have such a visit (ARR=1.29). Compared with whites, blacks were less likely to have an outpatient general medical visit (ARR=.93). Rural dwellers were less likely than urban dwellers to have such a visit (ARR=.64). Persons with drug or alcohol use disorders were less likely than those without such disorders to have an outpatient general medical visit (ARR=.95), and those with schizophrenia were less likely than those with any other psychiatric disorder examined to have such a visit.
   Conclusions: Individuals with serious mental illness had low use of outpatient general medical services. Integrated care models are needed to engage these individuals and eliminate disparities in morbidity and mortality.
C1 [Garcia, Maria E.; Schillinger, Dean] Univ Calif San Francisco, Sch Med, Dept Med, San Francisco, CA 94143 USA.
   [Vittinghoff, Eric] Univ Calif San Francisco, Sch Med, Dept Epidemiol & Biostat, San Francisco, CA USA.
   [Creasman, Jennifer M.] Univ Calif San Francisco, Sch Med, Clin & Translat Sci Inst, San Francisco, CA USA.
   [Mangurian, Christina] Univ Calif San Francisco, Sch Med, Dept Psychiat, San Francisco, CA USA.
   [Garcia, Maria E.; Schillinger, Dean; Mangurian, Christina] Zuckerberg Gen Hosp, San Francisco, CA 94110 USA.
   [Knapp, Penelope] Univ Calif Davis, Dept Psychiat & Behav Sci, Davis, CA 95616 USA.
   [Newcomer, John W.] Florida Atlantic Univ, Charles E Schmidt Coll Med, Dept Integrated Med Sci, Boca Raton, FL 33431 USA.
C3 University of California System; University of California San Francisco;
   University of California System; University of California San Francisco;
   University of California System; University of California San Francisco;
   University of California System; University of California San Francisco;
   University of California System; University of California Davis; State
   University System of Florida; Florida Atlantic University
RP Garcia, ME (corresponding author), Univ Calif San Francisco, Sch Med, Dept Med, San Francisco, CA 94143 USA.; Garcia, ME (corresponding author), Zuckerberg Gen Hosp, San Francisco, CA 94110 USA.
EM maria.garcia@ucsf.edu
OI Newcomer, John/0000-0003-2153-9382
FU National Institutes of Health (NIH) [D55HP23202]; National Institute of
   Diabetes and Digestive and Kidney Diseases [P30DK092924]; Comprehensive
   Center of Excellence for Health and Risk in Minority Youth and Young
   Adults, National Institute of Minority Health and Health Disparities
   [P60MD006902]; Foundation2Recovery; NIH Career Development Award
   [K23MH093689]; UCSF Hellman Fellows Award for Early-Career Faculty; NIH
   National Center for Advancing Translational Sciences [UL1 TR000004];
   Amgen Inc.; Otsuka America Pharmaceutical, Inc.; Reviva Pharmaceuticals,
   Inc.; Sunovion Pharmaceuticals, Inc.
FX Dr. Garcia was supported by grant D55HP23202 for Faculty Development in
   Primary Care from the National Institutes of Health (NIH). Dr.
   Schillinger was supported by center grant P30DK092924 from the National
   Institute of Diabetes and Digestive and Kidney Diseases to the Health
   Delivery Systems-Center for Diabetes Translational Research (CTSI) and
   by grant P60MD006902 from the Comprehensive Center of Excellence for
   Health and Risk in Minority Youth and Young Adults, National Institute
   of Minority Health and Health Disparities. Dr. Newcomer was supported by
   funds from Foundation2Recovery. Dr. Mangurian was supported by NIH
   Career Development Award K23MH093689, by the UCSF Hellman Fellows Award
   for Early-Career Faculty, and by grant UL1 TR000004 to the UCSF-CTSI
   from the NIH National Center for Advancing Translational Sciences. None
   of the funders had a role in the design and conduct of the study;
   collection, management, analysis, and interpretation of the data; and
   preparation, review, or approval of the manuscript. Dr. Newcomer reports
   receipt of funding, service on a data safety monitoring board, or
   service as a consultant for Amgen Inc., Otsuka America Pharmaceutical,
   Inc., Reviva Pharmaceuticals, Inc., and Sunovion Pharmaceuticals, Inc.
   The other authors report no financial relationships with commercial
   interests.
CR [Anonymous], STAT DEP MENT HLTH M
   [Anonymous], CAL MENT HLTH SUBST
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   [Anonymous], HHS PUB
   [Anonymous], PUTT MENS HLTH CAR D
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NR 38
TC 12
Z9 17
U1 0
U2 3
PU AMER PSYCHIATRIC PUBLISHING, INC
PI WASHINGTON
PA 800 MAINE AVE SW, SUITE 900, WASHINGTON, DC 20024 USA
SN 1075-2730
EI 1557-9700
J9 PSYCHIAT SERV
JI Psychiatr. Serv.
PD JUL 1
PY 2017
VL 68
IS 7
BP 689
EP 695
DI 10.1176/appi.ps.201600284
PG 7
WC Health Policy & Services; Public, Environmental & Occupational Health;
   Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services; Public, Environmental & Occupational
   Health; Psychiatry
GA FA0GZ
UT WOS:000405110900009
PM 28245706
OA Bronze
DA 2025-06-11
ER

PT J
AU Haraguchi, A
   Fukuzawa, M
   Iwami, S
   Nishimura, Y
   Motohashi, H
   Tahara, Y
   Shibata, S
AF Haraguchi, Atsushi
   Fukuzawa, Miyabi
   Iwami, Shiho
   Nishimura, Yutaro
   Motohashi, Hiroaki
   Tahara, Yu
   Shibata, Shigenobu
TI Night eating model shows time-specific depression-like behavior in the
   forced swimming test
SO SCIENTIFIC REPORTS
LA English
DT Article
ID HIGH-FAT DIET; ANTIDEPRESSANT ACTIVITY; METABOLIC SYNDROME;
   CIRCADIAN-RHYTHMS; TAIL SUSPENSION; CLOCK; DISORDERS; OBESITY; STRESS;
   RECEPTOR
AB The circadian clock system is associated with feeding and mood. Patients with night eating syndrome (NES) delay their eating rhythm and their mood declines during the evening and night, manifesting as time-specific depression. Therefore, we hypothesized that the NES feeding pattern might cause time-specific depression. We established new NES model by restricted feeding with high-fat diet during the inactive period under normal-fat diet ad libitum. The FST (forced swimming test) immobility time in the NES model group was prolonged only after lights-on, corresponding to evening and early night for humans. We examined the effect of the NES feeding pattern on peripheral clocks using PER2:: LUCIFERASE knock-in mice and an in vivo monitoring system. Caloric intake during the inactive period would shift the peripheral clock, and might be an important factor in causing the time-specific depression-like behavior. In the NES model group, synthesis of serotonin and norepinephrine were increased, but utilization and metabolism of these monoamines were decreased under stress. Desipramine shortened some mice's FST immobility time in the NES model group. The present study suggests that the NES feeding pattern causes phase shift of peripheral clocks and malfunction of the monoamine system, which may contribute to the development of time-specific depression.
C1 [Haraguchi, Atsushi; Fukuzawa, Miyabi; Iwami, Shiho; Nishimura, Yutaro; Motohashi, Hiroaki; Tahara, Yu; Shibata, Shigenobu] Waseda Univ, Sch Adv Sci & Engn, Lab Physiol & Pharmacol, Tokyo, Japan.
C3 Waseda University
RP Shibata, S (corresponding author), Waseda Univ, Sch Adv Sci & Engn, Lab Physiol & Pharmacol, Tokyo, Japan.
EM shibatas@waseda.jp
RI Haraguchi, Atsushi/ABC-6337-2020; Tahara, Yu/Q-4324-2018
OI Haraguchi, Atsushi/0000-0003-4162-2474; Tahara, Yu/0000-0002-3015-8883
FU Leading Graduate Program in Science and Engineering, Waseda University
   from MEXT, Japan; Council for Science, Technology and Innovation, SIP,
   "Technologies for creating next-generation agriculture, forestry and
   fisheries" (funding agency: Bio-oriented Technology Research Advancement
   Institution, NARO); Ministry of Education, Culture, Sports, Science and
   Technology of Japan [26220201]; MEXT, Japan [17J10069]; Grants-in-Aid
   for Scientific Research [17J10069] Funding Source: KAKEN
FX This work was partially supported by Grant-in-Aid for Japan Society for
   the Promotion of Science (JSPS) Research Fellow (17J10069) (A.H.), and
   by the Leading Graduate Program in Science and Engineering, Waseda
   University from MEXT, Japan (A.H.), in part by the Council for Science,
   Technology and Innovation, SIP, "Technologies for creating
   next-generation agriculture, forestry and fisheries" (funding agency:
   Bio-oriented Technology Research Advancement Institution, NARO) (S.S.),
   and in part by a Grant-in-Aid for Scientific Research (S) (26220201)
   from the Ministry of Education, Culture, Sports, Science and Technology
   of Japan (S.S.).
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NR 79
TC 18
Z9 18
U1 0
U2 11
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD JAN 18
PY 2018
VL 8
AR 1081
DI 10.1038/s41598-018-19433-8
PG 14
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Science & Technology - Other Topics
GA FS9LI
UT WOS:000422739300044
PM 29348553
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Yuenyong, I
   Potue, P
   Maneesai, P
   Khamseekaew, J
   Manimmanakorn, A
   Iampanichakul, M
   Pakdeechote, P
AF Yuenyong, Ittipon
   Potue, Prapassorn
   Maneesai, Putcharawipa
   Khamseekaew, Juthamas
   Manimmanakorn, Apiwan
   Iampanichakul, Metee
   Pakdeechote, Poungrat
TI Tangeretin Unravels Metabolic Dysfunction-Associated Fatty Liver Disease
   in Rats by Enhancing the IRS/Akt Pathway
SO LIFE-BASEL
LA English
DT Article
DE tangeretin; MAFLD; high-fat diet; insulin resistance; oxidative stress
ID OXIDATIVE STRESS; INSULIN-RESISTANCE; INFLAMMATION; HEPATOCYTES; GLUCOSE
AB Excessive high-fat diet (HFD) intake can precipitate metabolic dysfunction-associated fatty liver disease (MAFLD). Tangeretin is a citrus flavonoid possessing many biological properties. We examined the impact of tangeretin on MAFLD and its underlying mechanism. Rats were given HFD plus 15% fructose solution for four months to produce metabolic syndrome. Metabolic syndrome rats were administered 100 mg/kg of metformin or 25 mg/kg of tangeretin for the last four weeks. HFD-induced increased body weight, liver weight, adipose tissue weight, fasting blood glucose, serum insulin, total triglyceride, total cholesterol, and free fatty acids and reduced adiponectin and high-density lipoprotein cholesterol levels in metabolic syndrome, which were alleviated by tangeretin (p < 0.05). Tangeretin stabilized alanine transaminase activity, liver catalase, and inflammatory and oxidative stress markers in HFD rats compared to untreated HFD rats (p < 0.05). Tangeretin reduced hepatic steatosis induced by HFD. Downregulation of hepatic insulin receptor substrate-1 (IRS-1) and protein kinase B (Akt) protein expression in metabolic syndrome rats was recovered by tangeretin (p < 0.05). Metformin, an antihyperglycemic drug, produced comparable effects to tangeretin. In conclusion, tangeretin attenuates metabolic disorders and fatty liver induced by HFD in rats. The underlying mechanisms involve reducing oxidative stress, and inflammation and enhancing insulin sensitivity.
C1 [Yuenyong, Ittipon; Potue, Prapassorn; Maneesai, Putcharawipa; Khamseekaew, Juthamas; Manimmanakorn, Apiwan; Iampanichakul, Metee; Pakdeechote, Poungrat] Khon Kaen Univ, Fac Med, Dept Physiol, Khon Kaen 40002, Thailand.
C3 Khon Kaen University
RP Pakdeechote, P (corresponding author), Khon Kaen Univ, Fac Med, Dept Physiol, Khon Kaen 40002, Thailand.
EM bankyuenyong@kkumail.com; prappo@kku.ac.th; putcma@kku.ac.th;
   juthakh@kku.ac.th; mapiwa@kku.ac.th; meteiam@kku.ac.th; ppoung@kku.ac.th
RI Maneesai, Putcharawipa/AAK-4258-2021
OI Pakdeechote, Poungrat/0000-0001-8114-5954; Iampanichakul,
   Metee/0009-0009-8445-4096; Potue, Prapassorn/0000-0002-6356-735X
FU Fundamental Research Fund - National Science, Research and Innovation
   Fund; Research and Graduate Study, Khon Kaen University; Invitation
   Research Fund, Faculty of Medicine, Khon Kaen University, Khon Kaen,
   Thailand [IN67035]; Fundamental Research Fund - NSRF
FX This study was supported by the Fundamental Research Fund (which has
   received funding support from the "National Science, Research and
   Innovation Fund" or "NSRF"), Research and Graduate Study, Khon Kaen
   University, and the Invitation Research Fund (IN67035), Faculty of
   Medicine, Khon Kaen University, Khon Kaen, Thailand.
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NR 59
TC 0
Z9 0
U1 1
U2 1
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2075-1729
J9 LIFE-BASEL
JI Life-Basel
PD MAR 18
PY 2025
VL 15
IS 3
AR 491
DI 10.3390/life15030491
PG 16
WC Biology; Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics; Microbiology
GA 0RF0A
UT WOS:001454081100001
PM 40141836
OA gold
DA 2025-06-11
ER

PT J
AU Ringen, PA
   Engh, JA
   Birkenaes, AB
   Dieset, I
   Andreassen, OA
AF Ringen, Petter Andreas
   Engh, John A.
   Birkenaes, Astrid B.
   Dieset, Ingrid
   Andreassen, Ole A.
TI Increased mortality in schizophrenia due to cardiovascular disease - a
   non-systematic review of epidemiology, possible causes, and
   interventions
SO FRONTIERS IN PSYCHIATRY
LA English
DT Review
DE schizophrenia; mortality; metabolic syndrome X; physical training;
   lifestyle; cardiovascular diseases
ID SEVERE MENTAL-ILLNESS; INDUCED WEIGHT-GAIN; ALL-CAUSE MORTALITY;
   ATYPICAL ANTIPSYCHOTIC-DRUGS; METABOLIC SYNDROME; PHYSICAL-ACTIVITY;
   BIPOLAR DISORDER; RISK-FACTORS; PSYCHOTIC DISORDERS; PAIN INSENSITIVITY
AB Background: Schizophrenia is among the major causes of disability worldwide and the mortality from cardiovascular disease (CVD) is significantly elevated. There is a growing concern that this health challenge is not fully understood and efficiently addressed.
   Methods: Non-systematic review using searches in PubMed on relevant topics as well as selection of references based on the authors' experience from clinical work and research in the field.
   Results: In most countries, the standardized mortality rate in schizophrenia is about 2.5, leading to a reduction in life expectancy between 15 and 20 years. A major contributor of the increased mortality is due to CVD, with CVD mortality ranging from 40 to 50% in most studies. Important causal factors are related to lifestyle, including poor diet, lack of physical activity, smoking, and substance abuse. Recent findings suggest that there are overlapping pathophysiology and genetics between schizophrenia and CVD-risk factors, further increasing the liability to CVD in schizophrenia. Many pharmacological agents used for treating psychotic disorders have side effects augmenting CVD risk. Although several CVD-risk factors can be effectively prevented and treated, the provision of somatic health services to people with schizophrenia seems inadequate. Further, there is a sparseness of studies investigating the effects of lifestyle interventions in schizophrenia, and there is little knowledge about effective programs targeting physical health in this population.
   Discussion: The risk for CVD and CVD-related deaths in people with schizophrenia is increased, but the underlying mechanisms are not fully known. Coordinated interventions in different health care settings could probably reduce the risk. There is an urgent need to develop and implement effective programs to increase life expectancy in schizophrenia, and we argue that mental health workers should be more involved in this important task.
C1 [Ringen, Petter Andreas; Birkenaes, Astrid B.; Dieset, Ingrid; Andreassen, Ole A.] Univ Oslo, Oslo Univ Hosp, KG Jebsen Ctr Psychosis Res, NORMENT, Oslo, Norway.
   [Ringen, Petter Andreas; Birkenaes, Astrid B.; Dieset, Ingrid; Andreassen, Ole A.] Univ Oslo, Inst Clin Med, Oslo, Norway.
   [Ringen, Petter Andreas; Dieset, Ingrid; Andreassen, Ole A.] Oslo Univ Hosp, Div Mental Hlth & Addict, Oslo, Norway.
   [Engh, John A.] Vestfold Hosp Trust, Div Mental Hlth & Addict, Tonsberg, Norway.
C3 University of Oslo; University of Oslo; University of Oslo
RP Andreassen, OA (corresponding author), Oslo Univ Sykehus HF, Klin Psykisk Hele & Avhengighet, Sekjson Psykoseforskning TOP, Ulleval Sykehus, Bygg 49, N-0424 Oslo, Norway.
EM o.a.andreassen@medisin.uio.no
RI Engh, John/AAG-6446-2021; ringen, petter/C-5036-2011; Andreassen,
   Ole/AAY-7531-2020
OI Andreassen, Ole A./0000-0002-4461-3568
FU Oslo University Hospital; Research Council of Norway [223273];
   South-East Health Authority [2013-123]
FX The current study was supported by Oslo University Hospital, Research
   Council of Norway (#223273), and South-East Health Authority
   (#2013-123). We thank Daniel Quintana at the University of Oslo for help
   with proof-reading.
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NR 193
TC 269
Z9 288
U1 1
U2 12
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-0640
J9 FRONT PSYCHIATRY
JI Front. Psychiatry
PD SEP 26
PY 2014
VL 5
AR 137
DI 10.3389/fpsyt.2014.00137
PG 11
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA V46WA
UT WOS:000209913100002
PM 25309466
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Narita, K
   Murata, T
   Hamada, T
   Takahashi, T
   Kosaka, H
   Sudo, S
   Mizukami, K
   Yoshida, H
   Wada, Y
AF Narita, Kosuke
   Murata, Tetsuhito
   Hamada, Toshihiko
   Takahashi, Tetsuya
   Kosaka, Hirotaka
   Sudo, Satoru
   Mizukami, Kimiko
   Yoshida, Haruyoshi
   Wada, Yuji
TI Adiponectin multimer distribution, not absolute amount of plasma,
   correlates with depression severity in healthy elderly subjects
SO PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
LA English
DT Review
DE adiponectin; depression; elderly subjects; insulin resistance; multimer
   distribution
ID CARDIOVASCULAR-DISEASE; INSULIN-RESISTANCE; RISK
AB Adiponectin is an adipocyte-specific secretory protein that circulates in serum as three oligomeric complexes known as the high, medium and low molecular weight form (HMW, MMW and LMW). HMW adiponectin has been suggested to be a better predictor of metabolic variables, and it was recently reported that the ratio of HMW to total adiponectin or to LMW, not the absolute amount of plasma adiponectin, might be crucial in determining insulin sensitivity. Insulin resistance (IR) is considered to be a primary component of vascular risk factors. Although the association of depression with atherosclerotic vascular diseases has been well documented, the contribution of IR to the evolution and progression of depression-associated vascular morbidity and mortality remains unknown. The current preliminary study showed that the ratio of HMW to total adiponectin or to LMW, not the absolute amount of plasma adiponectin, was negatively associated with depression severity in healthy elderly subjects without metabolic syndrome. This pilot study supports a promising role of adiponectin multimer distribution for clarifying the pathophysiological mechanism by which depression is associated with increased risk for IR, leading to cardiovascular disease, metabolic syndrome or type 2 diabetes. (c) 2007 Published by Elsevier Inc.
C1 [Narita, Kosuke; Murata, Tetsuhito; Takahashi, Tetsuya; Kosaka, Hirotaka; Sudo, Satoru; Wada, Yuji] Univ Fukui, Dept Neuropsychiat, Fukui 9101193, Japan.
   [Hamada, Toshihiko; Yoshida, Haruyoshi] Univ Fukui, Dept Clin & Lab Sci, Fukui 9101193, Japan.
   [Mizukami, Kimiko] Jin Ai Univ, Dept Psychol, Fac Human Studies, Fukui 9158586, Japan.
C3 University of Fukui; University of Fukui
RP Murata, T (corresponding author), Univ Fukui, Dept Neuropsychiat, Fukui 9101193, Japan.
EM tmurata@u-fukui.ac.jp
RI Takahashi, Tetsuya/ABG-8566-2021; Kosaka, Hirotaka/AFG-5500-2022;
   Yoshida, Haruyoshi/IRZ-6376-2023
OI Kosaka, Hirotaka/0000-0003-2210-5025
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NR 24
TC 16
Z9 17
U1 0
U2 5
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0278-5846
EI 1878-4216
J9 PROG NEURO-PSYCHOPH
JI Prog. Neuro-Psychopharmacol. Biol. Psychiatry
PD JAN 1
PY 2008
VL 32
IS 1
BP 124
EP 127
DI 10.1016/j.pnpbp.2007.07.022
PG 4
WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA 268FV
UT WOS:000253565500017
PM 17761380
DA 2025-06-11
ER

PT J
AU Littman, AJ
   Damschroder, LJ
   Verchinina, L
   Lai, ZS
   Kim, HM
   Hoerster, KD
   Klingaman, EA
   Goldberg, RW
   Owen, RR
   Goodrich, DE
AF Littman, Alyson J.
   Damschroder, Laura J.
   Verchinina, Lilia
   Lai, Zongshan
   Kim, Hyungjin Myra
   Hoerster, Katherine D.
   Klingaman, Elizabeth A.
   Goldberg, Richard W.
   Owen, Richard R.
   Goodrich, David E.
TI National evaluation of obesity screening and treatment among veterans
   with and without mental health disorders
SO GENERAL HOSPITAL PSYCHIATRY
LA English
DT Article
DE Obesity; Weight management; Veterans; Serious mental illness; Depressive
   disorder
ID WEIGHT-MANAGEMENT PROGRAM; LIFE-STYLE INTERVENTION; CARDIOVASCULAR RISK;
   METABOLIC SYNDROME; ANXIETY DISORDERS; PRIMARY-CARE; ILLNESS; ADULTS;
   REDUCTION; SCHIZOPHRENIA
AB Objective: The objective was to determine whether obesity screening and weight management program participation and outcomes are equitable for individuals with serious mental illness (SMI) and depressive disorder (DD) compared to those without SMI/DD in Veterans Health Administration (VHA), the largest integrated US health system, which requires obesity screening and offers weight management to all in need.
   Methods: We used chart-reviewed, clinical and administrative VHA data from fiscal years 2010-2012 to estimate obesity screening and participation in the VHA's weight management program (MOVE!) across groups. Six-and 12-month weight changes in MOVE! participants were estimated using linear mixed models adjusted for confounders.
   Results: Compared to individuals without SMI/DD, individuals with SMI or DD were less frequently screened for obesity (94%-94.7% vs. 95.7%) but had greater participation in MOVE! (10.1%-10.4% vs. 7.4%). MOVE! participants with SMI or DD lost approximately 1 lb less at 6 months. At 12 months, average weight loss for individuals with SMI or neither SMI/DD was comparable (-3.5 and -3.3 lb, respectively), but individuals with DD lost less weight (mean=-2.7 lb).
   Conclusions: Disparities in obesity screening and treatment outcomes across mental health diagnosis groups were modest. However, participation in MOVE! was low for every group, which limits population impact. Published by Elsevier Inc.
C1 [Littman, Alyson J.] VA Puget Sound Healthcare Syst, Seattle Div Epidemiol Res & Informat Ctr ERIC, Seattle, WA 98108 USA.
   [Littman, Alyson J.] Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA.
   [Damschroder, Laura J.; Verchinina, Lilia; Lai, Zongshan; Kim, Hyungjin Myra; Goodrich, David E.] VA Ann Arbor Healthcare Syst, CCMR, Ann Arbor, MI 48105 USA.
   [Lai, Zongshan; Goodrich, David E.] Univ Michigan, Sch Med, Dept Psychiat, Ann Arbor, MI 48109 USA.
   [Kim, Hyungjin Myra] Univ Michigan, Ctr Stat Consultat & Res, Ann Arbor, MI 48109 USA.
   [Hoerster, Katherine D.] VA Puget Sound Healthcare Syst, Seattle Div Mental Hlth Serv, Seattle, WA 98108 USA.
   [Hoerster, Katherine D.] Univ Washington, Dept Psychiat & Behav Sci, Seattle, WA 98195 USA.
   [Klingaman, Elizabeth A.; Goldberg, Richard W.] VA Capitol Hlth Care Network, Mental Illness Res Educ & Clin Ctr, Baltimore, MD USA.
   [Owen, Richard R.] Cent Arkansas Vet Healthcare Syst, Ctr Mental Healthcare & Outcomes Res, Little Rock, AR USA.
   [Owen, Richard R.] Univ Arkansas Med Sci, Coll Med, Dept Psychiat, Little Rock, AR 72205 USA.
   [Klingaman, Elizabeth A.] Univ Maryland, Sch Med, Dept Psychiat, Baltimore, MD 21201 USA.
C3 US Department of Veterans Affairs; Veterans Health Administration (VHA);
   Vet Affairs Puget Sound Health Care System; University of Washington;
   University of Washington Seattle; US Department of Veterans Affairs;
   Veterans Health Administration (VHA); VA Ann Arbor Healthcare System;
   University of Michigan System; University of Michigan; University of
   Michigan System; University of Michigan; US Department of Veterans
   Affairs; Veterans Health Administration (VHA); Vet Affairs Puget Sound
   Health Care System; University of Washington; University of Washington
   Seattle; US Department of Veterans Affairs; Veterans Health
   Administration (VHA); Central Arkansas Veterans Healthcare System;
   University of Arkansas System; University of Arkansas Medical Sciences;
   University System of Maryland; University of Maryland Baltimore
RP Littman, AJ (corresponding author), VA Puget Sound Healthcare Syst, Seattle Epidemiol Res & Informat Ctr ERIC, 1660 South Columbia Way,S-152-E, Seattle, WA 98108 USA.
EM Alyson.littman@va.gov; Laura.damschroder@va.gov;
   Lilia.verchinina@va.gov; Zongshan.Lai@va.gov; Myrakim@umich.edu;
   Katherine.hoerster@va.gov; Elizabeth.klingaman@va.gov;
   Richard.goldberg@va.gov; Richard.Owen2@va.gov; David.goodrich2@va.gov
RI Damschroder, Laura/A-1142-2007; Owen, Richard/HTM-1385-2023
OI Goodrich, David/0000-0003-3232-2189; Damschroder, Laura
   J./0000-0002-3657-8459
FU VHA Center for Health Promotion & Disease Prevention (NCP); VA Health
   Services Research and Development Quality Enhancement Research
   Initiative (QUERI) [QLP 55-017]; Rehabilitation R&D Career Development
   Award [6982]
FX This study was funded by was initiated at the request of the VHA Center
   for Health Promotion & Disease Prevention (NCP). Funding was provided by
   VA Health Services Research and Development Quality Enhancement Research
   Initiative (QUERI) programs for Diabetes and Mental Health research as a
   locally initiated project (QLP 55-017). Dr. Littman's time was supported
   by a Rehabilitation R&D Career Development Award (#6982). The authors
   would like to acknowledge the support of Dr. Amy M. Kilbourne, Dr.
   Kenneth J. Jones, Dr. Caroline R. Richardson and Ms. Trang Lance in this
   work. The views expressed in this article are those of the authors and
   do not necessarily represent the views of the Veterans Administration.
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NR 59
TC 45
Z9 50
U1 0
U2 10
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0163-8343
EI 1873-7714
J9 GEN HOSP PSYCHIAT
JI Gen. Hosp. Psych.
PD JAN-FEB
PY 2015
VL 37
IS 1
BP 7
EP 13
DI 10.1016/j.genhosppsych.2014.11.005
PG 7
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA AZ2CQ
UT WOS:000348042700005
PM 25500194
DA 2025-06-11
ER

PT J
AU Björntorp, P
   Rosmond, R
AF Björntorp, P
   Rosmond, R
TI The metabolic syndrome -: a neuroendocrine disorder?
SO BRITISH JOURNAL OF NUTRITION
LA English
DT Article; Proceedings Paper
CT Symposium on Diet and the Metabolic Syndrome
CY AUG 26-28, 1999
CL YSTAD, SWEDEN
SP Swedish Nutrit Fdn, Swedish Soc Med
DE metabolic syndrome; HPA axis; stress; glucocorticoid receptor
ID FRAGMENT-LENGTH-POLYMORPHISM; INSULIN-RESISTANCE; CORTISOL SECRETION;
   SALIVARY CORTISOL; ADIPOSE-TISSUE; BLOOD-PRESSURE; STRESS; DISEASE;
   SYSTEM; LEPTIN
AB Central obesity is a powerful predictor for disease. By utilizing salivary cortisol measurements throughout the day, it has now been possible to show on a population basis that perceived stress-related cortisol secretion frequently is elevated in this condition. This is followed by insulin resistance, central accumulation of body fat, dyslipidaemia and hypertension (the metabolic syndrome). Socio-economic and psychosocial handicaps are probably central inducers of hyperactivity of the hypothalamic-pituitary adrenal (HPA) axis. Alcohol, smoking and traits of psychiatric disease are also involved. In a minor part of the population a dysregulated, depressed function of the HPA axis is present, associated with low secretion of sex steroid and growth hormones, and increased activity of the sympathetic nervous system. This condition is followed by consistent abnormalities indicating the metabolic syndrome. Such 'burned-out' function of the HPA axis has previously been seen in subjects exposed to environmental stress of long duration. The feedback control of the HPA axis by central glucocorticoid receptors (GR) seems inefficient, associated with a polymorphism in the 5 ' end of the GR gene locus. Homozygotes constitute about 14 % of Swedish men (women to be examined). Such men have a poorly controlled cortisol secretion, abdominal obesity, insulin resistance and hypertension. Furthermore, polymorphisms have been identified in the regulatory domain of the GR gene that are associated with elevated cortisol secretion; polymorphisms in dopamine and leptin receptor genes are associated with sympathetic nervous system activity, with elevated and low blood pressure, respectively. These results suggest a complex neuroendocrine background to the metabolic syndrome, where the kinetics of the regulation of the HPA axis play a central role.
C1 Gothenburg Univ, Sahlgrens Hosp, Dept Heart & Lung Dis, S-41345 Gothenburg, Sweden.
C3 University of Gothenburg; Sahlgrenska University Hospital
RP Gothenburg Univ, Sahlgrens Hosp, Dept Heart & Lung Dis, S-41345 Gothenburg, Sweden.
EM per.bjorntorp@hjl.gu.se
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NR 36
TC 221
Z9 242
U1 0
U2 12
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1145
EI 1475-2662
J9 BRIT J NUTR
JI Br. J. Nutr.
PD MAR
PY 2000
VL 83
SU 1
BP S49
EP S57
DI 10.1017/S0007114500000957
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Nutrition & Dietetics
GA 321NN
UT WOS:000087461700009
PM 10889792
DA 2025-06-11
ER

PT J
AU Garza-González, S
   Nieblas, B
   Solbes-Gochicoa, MM
   Altamirano, J
   García, N
AF Garza-Gonzalez, Salvador
   Nieblas, Bianca
   Solbes-Gochicoa, Maria M.
   Altamirano, Julio
   Garcia, Noemi
TI Intermittent Fasting as Possible Treatment for Heart Failure
SO CURRENT VASCULAR PHARMACOLOGY
LA English
DT Review
DE Caloric restriction; cardiovascular diseases; insulin resistance;
   obesity; metabolic syndrome; oxidative stress; ketosis; intermittent
   fasting
ID HIGH-FAT-DIET; CONTINUOUS ENERGY RESTRICTION; CARDIOMETABOLIC
   RISK-FACTORS; CARDIOVASCULAR-DISEASE RISK; GROWTH-FACTOR 21; PPAR-ALPHA;
   CIRCADIAN CLOCK; LIPID-METABOLISM; WEIGHT-LOSS; SCIENTIFIC STATEMENT
AB Western-style diet often leads to food overconsumption, which triggers the development of comorbidities, such as obesity, insulin resistance, hypercholesterolemia, hypertriglyceridemia, type 2 diabetes, and heart failure (HF). Several studies suggest that intermittent fasting (IF) protects against the development of those morbidities. This study presents evidence of the beneficial effects of IF on HF. Based on the current evidence, we discuss the potential molecular mechanisms by which IF works and where liver ketone bodies (KBs) play important roles. There is evidence that IF promotes a metabolic switch in highly metabolic organs, such as the heart, which increases the use of KBs during fasting. However, besides their role as energy substrates, KBs participate in the signaling pathways that control the expression of genes involved in oxidative stress protection and metabolism. Several molecular factors, such as adenosine monophosphate-activated protein kinase (AMPK), peroxisome proliferator-activated receptor, fibroblast growth factor 21 (FGF21), sirtuins, and nuclear factor erythroid 2-related factor 2 (Nrf2) are involved. Furthermore, IF appears to maintain circadian rhythm, which is essential for highly metabolically active organs. Finally, we highlight the important research topics that need to be pursued to improve current knowledge and strengthen the potential of IF as a preventive and therapeutic approach to HF.
C1 [Garza-Gonzalez, Salvador; Nieblas, Bianca; Solbes-Gochicoa, Maria M.; Altamirano, Julio; Garcia, Noemi] Tecnol Monterrey, Escuela Med & Ciencias Salud Med Cardiovasc & Met, Monterrey, Nuevo Leon, Mexico.
   [Altamirano, Julio; Garcia, Noemi] Tecnol Monterrey, Hosp Zambrano Hell, Ctr Invest Biomed, Monterrey, Nuevo Leon, Mexico.
   [Garcia, Noemi] Tecnol Monterrey, Inst Obes, Monterrey, Nuevo Leon, Mexico.
C3 Tecnologico de Monterrey; Tecnologico de Monterrey; Tecnologico de
   Monterrey
RP García, N (corresponding author), Hosp Zambrano Hellion, Tecnol Monterrey, Escuela Med & Ciencias Salud, Batallon San Patricio 112, San Pedro Garza Garcia 66278, Nuevo Leon, Mexico.
EM garcianr@tec.mx
RI Garcia, Noemi/T-4688-2019
OI Noemi, Garcia/0000-0002-1137-0117; Nieblas, Bianca/0000-0002-8513-6163
FU Medicine School and The Institute for Obesity Research of Tecnologico de
   Monterrey; CONACyT
FX The authors acknowledge the Medicine School and The Institute for
   Obesity Research of Tecnologico de Monterrey for partially supporting
   this work, and scholarships from CONACyT to Bianca Nieblas.
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NR 104
TC 6
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U1 0
U2 9
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1570-1611
EI 1875-6212
J9 CURR VASC PHARMACOL
JI Current Vascular Pharmacology
PY 2022
VL 20
IS 3
BP 260
EP 271
DI 10.2174/1570161120666220610151915
PG 12
WC Pharmacology & Pharmacy; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Cardiovascular System & Cardiology
GA 5D0HW
UT WOS:000864633000006
PM 35692158
DA 2025-06-11
ER

PT J
AU Scheen, AJ
AF Scheen, A. J.
TI CB1 receptor blockade and its impact on cardiometabolic risk factors:
   Overview of the RIO programme with rimonabant
SO JOURNAL OF NEUROENDOCRINOLOGY
LA English
DT Article; Proceedings Paper
CT Workshop on Endocannabinoids in Endocrinology, Metabolism and
   Cardiovascular Diseases, Scientific Background and Clinical Perspectives
CY JUL, 2007
CL Padua, ITALY
DE endocannabinoid system; cardiometabolic risk; CB1 receptor; obesity;
   rimonabant; type 2 diabetes
ID ENDOCANNABINOID SYSTEM; WEIGHT-LOSS; OVERWEIGHT PATIENTS;
   GLUCOSE-TOLERANCE; OBESITY; DRUG; MANAGEMENT; METAANALYSIS; ANTAGONIST;
   MECHANISMS
AB Rimonabant, the first selective CB1 receptor antagonist in clinical use, has been extensively investigated in the Rimonabant in Obesity (RIO) programme, comprising four 1-2 year placebo-controlled randomised clinical trials recruiting more than 6600 overweight/obese patients with or without co-morbidities. Rimonabant 20 mg daily consistently reduced body weight, waist circumference, triglycerides, blood pressure, insulin resistance and C-reactive protein levels, and increased HDL cholesterol concentrations in both non-diabetic and type-2 diabetic overweight/obese patients. Adiponectin levels were increased, an effect that correlated with HDL cholesterol augmentation, while small dense LDL cholesterol levels were decreased in patients receiving rimonabant 20 mg compared with those receiving placebo in RIO Lipids. Furthermore, in RIO Diabetes, a 0.7% reduction in glycated haemoglobin (HbA1c) levels was observed in metformin- or sulphonylurea-treated patients with type-2 diabetes, an effect recently confirmed in the 6-month SERENADE (Study Evaluating Rimonabant Efficacy in drug-NAive DiabEtic patients) trial in drug-naive diabetic patients. Almost half of metabolic changes occurred beyond weight loss, in agreement with direct peripheral effects. The positive effects observed after 1 year were maintained after 2 years. Rimonabant was generally well-tolerated, but with a slightly higher incidence of depressed mood disorders, anxiety, nausea and dizziness compared with placebo. In clinical practice, rimonabant has to be prescribed to the right patient, i.e. overweight/obese subjects with cardiometabolic risk factors and with no major depressive illness and/or ongoing antidepressive treatment, in order to both maximise efficacy and minimise safety issues. New trials are supposed to confirm the potential role of rimonabant in patients with abdominal adiposity, atherogenic dyslipidaemia and/or type-2 diabetes, i.e. at high cardiometabolic risk.
C1 CHU Sart Tilman, Dept Med, Div Diabet Nutr & Metab Disorders, B-4000 Liege, Belgium.
C3 University of Liege
RP Scheen, AJ (corresponding author), CHU Sart Tilman, Dept Med, Div Diabet Nutr & Metab Disorders, B35, B-4000 Liege, Belgium.
EM andre.scheen@chu.ulg.ac.be
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NR 47
TC 51
Z9 56
U1 0
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0953-8194
EI 1365-2826
J9 J NEUROENDOCRINOL
JI J. Neuroendocrinol.
PD MAY
PY 2008
VL 20
SU 1
BP 139
EP 146
DI 10.1111/j.1365-2826.2008.01681.x
PG 8
WC Endocrinology & Metabolism; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Endocrinology & Metabolism; Neurosciences & Neurology
GA 289NI
UT WOS:000255060800023
PM 18426513
OA Green Submitted, Bronze
DA 2025-06-11
ER

PT J
AU Lafarga, T
   Hayes, M
AF Lafarga, Tomas
   Hayes, Maria
TI Bioactive peptides from meat muscle and by-products: generation,
   functionality and application as functional ingredients
SO MEAT SCIENCE
LA English
DT Review
DE Meat by-products; Blood; Bioactive peptides; PEP; ACE-I; Mental health
ID I-CONVERTING-ENZYME; ANTIOXIDANT ACTIVITY; BOVINE HEMOGLOBIN; INHIBITORY
   PEPTIDES; OPIOID-PEPTIDES; ANTIHYPERTENSIVE ACTIVITY; MYOFIBRILLAR
   PROTEINS; ANGIOTENSIN; IDENTIFICATION; PURIFICATION
AB Bioactive peptides are sequences of between 2-30 amino acids in length that impart a positive health effect to the consumer when ingested. They have been identified from a range of foods, including milk and muscle sources including beef, chicken, pork and marine muscles. The myriad of peptides identified from these sources have known antihypertensive, opioid, antioxidant, antithrombotic and other bioactivities. Indeed, bioactive peptides could play a role in the prevention of diseases associated with the development of metabolic syndrome and mental health diseases.
   The aim of this work is to present an overview of the bioactive peptides identified in muscle proteins and by-products generated during the processing of meat. The paper looks at the isolation, enrichment and characterisation strategies that have been employed to date to generate bioactive peptides and the potential future applications of these peptides in functional foods for the prevention of heart and mental health problems and obesity. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Lafarga, Tomas; Hayes, Maria] TEAGASC, Irish Agr & Food Dev Author, Food BioSci Dept, Dublin 15, Ireland.
C3 Teagasc
RP Hayes, M (corresponding author), TEAGASC, Food Res Ctr, Dublin 15, Ireland.
EM maria.hayes@teagasc.ie
RI Lafarga, Tomas/N-9057-2018
OI Lafarga, Tomas/0000-0002-1923-7214
FU Teagasc Walsh Fellowship; Irish Department of Food, Agriculture and the
   Marine (DAFM); Food Institutional Research Measure (FIRM) - Irish
   Government under the National Development Plan
FX Tomas Lafarga is in receipt of a Teagasc Walsh Fellowship. This work
   forms part of the ReValueProtein Research Programme which is supported
   by the Irish Department of Food, Agriculture and the Marine (DAFM) and
   the Food Institutional Research Measure (FIRM) which are both funded by
   the Irish Government under the National Development Plan 2007-2013.
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NR 112
TC 270
Z9 281
U1 4
U2 338
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0309-1740
EI 1873-4138
J9 MEAT SCI
JI Meat Sci.
PD OCT
PY 2014
VL 98
IS 2
BP 227
EP 239
DI 10.1016/j.meatsci.2014.05.036
PG 13
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA AN1HO
UT WOS:000340333500023
PM 24971811
DA 2025-06-11
ER

PT J
AU Bartoli, F
   Carrà, G
   Crocamo, C
   Carretta, D
   Clerici, M
AF Bartoli, Francesco
   Carra, Giuseppe
   Crocamo, Cristina
   Carretta, Daniele
   Clerici, Massimo
TI Metabolic Syndrome in People Suffering from Posttraumatic Stress
   Disorder: A Systematic Review and Meta-Analysis
SO METABOLIC SYNDROME AND RELATED DISORDERS
LA English
DT Review
ID INSULIN-RESISTANCE; CARDIOVASCULAR-DISEASE; ATYPICAL ANTIPSYCHOTICS;
   VIETNAM VETERANS; BIPOLAR DISORDER; RELATIVE RISK; ASSOCIATION;
   SCHIZOPHRENIA; HYPERTENSION; PREVALENCE
AB Background: Previous reports showed a high prevalence of obesity, diabetes, hypertension, and dyslipidemia among people suffering from posttraumatic stress disorder (PTSD). However, there is a lack of reviews that systematically analyze the relationship between PTSD and metabolic syndrome. We conducted a systematic review and meta-analysis aimed at estimating the association between PTSD and metabolic syndrome. Methods: We systematically searched PubMed, Embase, and Web of Science. We included observational studies assessing the prevalence of metabolic syndrome in a sample with PTSD and in a comparison group without PTSD. Data were analyzed using Review manager 5.1. Odds ratios (OR) with 95% confidence intervals were used as an association measure for pooled analysis, based on a random-effects model. Results: Six articles were eligible according to the inclusion criteria, for an overall number of 528 individuals suffering from PTSD and 846 controls without PTSD. The pooled OR for metabolic syndrome for people with PTSD was 1.37 (1.03-1.82). Statistical heterogeneity between the included studies was low (I-2=22%). Conclusions: Despite some limitations, the findings of this systematic review and meta-analysis confirmed our hypothesis that individuals suffering from PTSD have a greater risk of metabolic syndrome. The potential role of unknown factors or mediators that might clarify the nature of this association needs further research.
C1 [Bartoli, Francesco; Carretta, Daniele; Clerici, Massimo] Univ Milano Bicocca, Dept Surg & Interdisciplinary Med, Milan, Italy.
   [Carra, Giuseppe] UCL, Mental Hlth Sci Unit, Fac Brain Sci, London, England.
   [Crocamo, Cristina] San Gerardo Hosp, Dept Mental Hlth, Monza, Italy.
C3 University of Milano-Bicocca; University of London; University College
   London; San Gerardo Hospital
RP Bartoli, F (corresponding author), Univ Milano Bicocca, Dept Surg & Interdisciplinary Med, Via Cadore 48, I-20900 Monza, Italy.
EM francesco.bartoli@fastwebmail.it
RI Crocamo, Cristina/I-4355-2019; Clerici, Massimo/U-3074-2019; Bartoli,
   Francesco/K-5755-2016; Carra, Giuseppe/C-6091-2012; Crocamo,
   Cristina/B-5404-2014
OI Bartoli, Francesco/0000-0003-2612-4119; Carra,
   Giuseppe/0000-0002-6877-6169; Crocamo, Cristina/0000-0002-2979-2107;
   Clerici, Massimo/0000-0001-8769-6474
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NR 59
TC 74
Z9 80
U1 0
U2 12
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-4196
EI 1557-8518
J9 METAB SYNDR RELAT D
JI Metab. Syndr. Relat. Disord.
PD OCT 1
PY 2013
VL 11
IS 5
BP 301
EP 308
DI 10.1089/met.2013.0010
PG 8
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Research & Experimental Medicine
GA 220JZ
UT WOS:000324580800002
PM 23758060
DA 2025-06-11
ER

PT J
AU Cagampang, FR
   Poore, KR
   Hanson, MA
AF Cagampang, Felino R.
   Poore, Kirsten R.
   Hanson, Mark A.
TI Developmental origins of the metabolic syndrome: Body clocks and stress
   responses
SO BRAIN BEHAVIOR AND IMMUNITY
LA English
DT Review
DE Metabolic syndrome; Circadian rhythm; Hypothalamic-pituitary-adrenal
   axis; Nutrition; Developmental origins of health and disease; Stress
   response; Body clocks
ID PITUITARY-ADRENAL AXIS; GLUCOCORTICOID-RECEPTOR; CIRCADIAN CLOCK;
   BIRTH-WEIGHT; HPA AXIS; OBESITY; EXPRESSION; CORTISOL; BEHAVIOR;
   TRANSCRIPTION
AB The prevalence of the metabolic syndrome, which represents a spectrum of metabolic and cardiovascular disorders, continues to increase at an alarming rate in contemporary society. Inadequate responses of an individual to environmental challenges such as unbalanced diet or lack of physical exercise during their life course has been recognised to increase risk of this pathological condition. Recent evidence suggests that this may involve alterations in the settings of the circadian clock system, which consists of oscillating molecular pacemakers found not only in the hypothalamic region of the brain but also in most peripheral tissues, and of the hypothalamic-pituitary-adrenal (HPA) axis which regulates stress responses. These two systems are now known to interact to produce an integrated response to environmental challenges. In this review, we highlight the importance of environmental cues during early development in establishing the homeostatic set-points of the circadian clock and HPA stress systems. These effects can operate within the normal range and are not in themselves pathological, but can nevertheless affect an individual's response to environmental challenges in adult life and thus their risk of the metabolic syndrome. (C) 2010 Elsevier Inc. All rights reserved.
C1 [Cagampang, Felino R.; Poore, Kirsten R.; Hanson, Mark A.] Univ Southampton, Sch Med, Inst Dev Sci, Southampton SO16 6YD, Hants, England.
C3 University of Southampton
RP Hanson, MA (corresponding author), Univ Southampton, Sch Med, Southampton Gen Hosp MP 887,Inst Dev Sci, Dev Origins Hlth & Dis Div, Tremona Rd, Southampton SO16 6YD, Hants, England.
EM m.hanson@soton.ac.uk
RI Hanson, Mark/AAE-8236-2019; Poore, Kirsten/H-3949-2011; Cagampang,
   Felino/AAG-5141-2019
OI Poore, Kirsten/0000-0002-1455-0615; Hanson, Mark/0000-0002-6907-613X;
   Cagampang, Felino Ramon/0000-0003-4404-9853
FU British Heart Foundation; Biotechnology and Biological Sciences Research
   Council (BBSRC); Gerald Kerkut Trust; BBSRC [BB/G01812X/1] Funding
   Source: UKRI
FX The work of the authors is supported by the British Heart Foundation,
   Biotechnology and Biological Sciences Research Council (BBSRC), and
   Gerald Kerkut Trust.
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NR 51
TC 36
Z9 42
U1 0
U2 14
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0889-1591
EI 1090-2139
J9 BRAIN BEHAV IMMUN
JI Brain Behav. Immun.
PD FEB
PY 2011
VL 25
IS 2
BP 214
EP 220
DI 10.1016/j.bbi.2010.09.005
PG 7
WC Immunology; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Neurosciences & Neurology; Psychiatry
GA 712XL
UT WOS:000286699500002
PM 20851177
DA 2025-06-11
ER

PT J
AU Roman, B
   Carta, L
   Angel, M
   Martínez-González
   Serra-Majem, L
AF Roman, Blanca
   Carta, Laura
   Angel, Miguel
   Martinez-Gonzalez
   Serra-Majem, Lluis
TI Effectiveness of the Mediterranean diet in the elderly
SO CLINICAL INTERVENTIONS IN AGING
LA English
DT Review
DE Mediterranean diet; elderly; health; review
AB The Mediterranean diet is known to be one of the healthiest dietary patterns in the world due to its relation with a low morbidity and mortality for some chronic diseases. The purpose of this study was to review literature regarding the relationship between Mediterranean diet and healthy aging. A MEDLINE search was conducted looking for literature regarding the relationship between Mediterranean diet and cardiovascular disease (or risk factors for cardiovascular disease), cancer, mental health and longevity and quality of life in the elderly population (65 years or older). A selection of 36 articles met the criteria of selection. Twenty of the studies were about Mediterranean diets and cardiovascular disease, 2 about Mediterranean diets and cancer, 3 about Mediterranean diets and mental health and 11 about longevity (overall survival) or mental health. The results showed that Mediterranean diets had benefits on risks factors for cardiovascular disease such as lipoprotein levels, endothelium vasodilatation, insulin resistance, the prevalence of the metabolic syndrome, antioxidant capacity, the incidence of acute myocardial infarction, and cardiovascular mortality. Some positive associations with quality of life and inverse associations with the risk of certain cancers and with overall mortality were also reported.
C1 [Roman, Blanca; Serra-Majem, Lluis] Univ Barcelona Sci Pk, Mediterranean Diet Fdn, Barcelona 08028, Spain.
   [Carta, Laura] Univ Cagliari, Unit Physiol & Human Nutr, Dept Biosyst & Appl Sci, I-09124 Cagliari, Italy.
   [Martinez-Gonzalez] Univ Navarra, Dept Epidemiol & Publ Hlth, E-31080 Pamplona, Spain.
   [Serra-Majem, Lluis] Univ Las Palmas Gran Canaria, Dept Clin Sci, Las Palmas Gran Canaria, Spain.
C3 University of Cagliari; University of Navarra; Universidad de Las Palmas
   de Gran Canaria
RP Serra-Majem, L (corresponding author), Univ Barcelona Sci Pk, Mediterranean Diet Fdn, Parc Cient Barcelona,Baldiri Reixac,4 Torre D, Barcelona 08028, Spain.
EM lserra@dcc.ulpgc.es
RI Serra-Majem, Lluis/I-6708-2019; Martinez-Gonzalez, Miguel/AAE-7669-2019;
   ANGEL, MIGUEL/GVS-9068-2022
OI Serra-Majem, Lluis/0000-0002-9658-9061; Martinez-Gonzalez, Miguel
   A./0000-0002-3917-9808
FU Spanish Ministry of Health; Fondo de Investigacion Sanitaria
   [RD06/0045/0009]
FX Grant Support: By the Spanish Ministry of Health (RED: Alimentacion
   saludable en la prevencion primaria de enfermedades cronicas: la Red
   Predimed. Dentro de las Redes Tematicas de Investigacion Cooperativa
   Sanitaria (RETICs). Fondo de Investigacion Sanitaria, RD06/0045/0009).
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NR 67
TC 96
Z9 105
U1 2
U2 40
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-1998
J9 CLIN INTERV AGING
JI Clin. Interv. Aging
PY 2008
VL 3
IS 1
BP 97
EP 109
PG 13
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA V21WW
UT WOS:000208238700011
PM 18494169
OA Green Accepted, Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Hosseini, H
   Ghavidel, F
   Aliyari, M
   Hashemy, SI
   Jamialahmadi, T
   Sahebkar, A
AF Hosseini, Hossein
   Ghavidel, Farideh
   Aliyari, Mahdieh
   Hashemy, Seyed Isaac
   Jamialahmadi, Tannaz
   Sahebkar, Amirhossein
TI Effect of Nigella sativa Intake on Oxidative Stress and
   Inflammation in Patients with Metabolic Syndrome and Related Disorders:
   A Systematic Review and Meta-analysis of Randomized Controlled Trials
SO CURRENT PHARMACEUTICAL BIOTECHNOLOGY
LA English
DT Review
DE Metabolic syndrome; inflammation; Nigella sativa; oxidative stress;
   meta-analysis; systematic review
ID DOUBLE-BLIND; OBESE WOMEN; BLACK SEEDS; THYMOQUINONE; OIL; CONSTITUENT;
   EXTRACT; BIOMARKERS; ARTHRITIS; DISEASE
AB Background: Several studies have shown that the intake of N. sativa has a beneficial effect on metabolic syndrome and related disorders. In this meta-analysis, our primary objective was to assess the impact of Nigella sativa consumption on inflammation and oxidative stress biomarkers among individuals diagnosed with metabolic syndrome and its associated conditions. Methods: Our search was conducted on prominent online databases such as Web of Science, Scopus, PubMed, and EMBASE, utilizing relevant keywords until August 2023. Results: This meta-analysis was performed on 16 RCTs comprising 1033 participants. Our results showed that intake of Nigella sativa significantly decreased CRP (SMD: -0.60; (95% CI: from -0.96 to -0.23); P = 0.00), TNF-alpha (SMD: -0.53; (95% CI: from -0.74 to -0.53); P = 0.00); IL-6 (SMD: -0.54 ; (95% CI: from -1.01 to -0.07); P = 0.02), and MDA: (SMD: -1.28; (95% CI: from -2.11 to -0.46); P = 0.00) levels. In addition, SOD: (SMD: 1.35; (95% CI, from 0.77 to 1.93); P = 0.00) and TAC (SMD: 2.82; (95% CI, from 0.55 to 5.084); P = 0.01) levels significantly increased in the intervention group compared to the placebo group. Conclusion: Our results showed that THE consumption of N. sativa could be associated with improved oxidative stress and inflammation in patients with metabolic syndrome and related disorders.
C1 [Hosseini, Hossein; Ghavidel, Farideh; Aliyari, Mahdieh; Hashemy, Seyed Isaac] Mashhad Univ Med Sci, Fac Med, Dept Clin Biochem, Mashhad, Iran.
   [Jamialahmadi, Tannaz] Mashhad Univ Med Sci, Int UNESCO Ctr Hlth Related Basic Sci & Human Nutr, Mashhad, Iran.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Biotechnol Res Ctr, Mashhad, Iran.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Appl Biomed Res Ctr, Mashhad, Iran.
C3 Mashhad University of Medical Sciences; Mashhad University of Medical
   Sciences; Mashhad University of Medical Sciences; Mashhad University of
   Medical Sciences
RP Sahebkar, A (corresponding author), Mashhad Univ Med Sci, Pharmaceut Technol Inst, Biotechnol Res Ctr, Mashhad, Iran.
EM amir_saheb2000@yahoo.com
RI Hosseini, Hossein/AAX-5350-2021; Sahebkar, Amirhossein/B-5124-2018;
   Hashemy, Seyed Isaac/A-2693-2017
OI Hashemy, Seyed Isaac/0000-0002-1323-5250
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NR 77
TC 0
Z9 0
U1 4
U2 6
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1389-2010
EI 1873-4316
J9 CURR PHARM BIOTECHNO
JI Curr. Pharm. Biotechnol.
PY 2024
VL 25
IS 7
BP 896
EP 907
DI 10.2174/0113892010266109230928000134
PG 12
WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
GA RD0E1
UT WOS:001225607100007
PM 37859312
DA 2025-06-11
ER

PT J
AU Glasgow, TE
   Burch, JB
   Arcan, C
   Fuemmeler, BF
AF Glasgow, Trevin E.
   Burch, James B.
   Arcan, Chrisa
   Fuemmeler, Bernard F.
TI Cancer Prevention Among Firefighters: Examining Lifestyle, Screening
   Behavior, and Beliefs
SO WORKPLACE HEALTH & SAFETY
LA English
DT Article
DE firefighters; cancer beliefs; cancer screening; lifestyle behaviors;
   mental health; work-life balance
ID PHYSICAL-ACTIVITY; PROFESSIONAL FIREFIGHTERS; METABOLIC SYNDROME; HEALTH
   BEHAVIORS; SLEEP QUALITY; INFORMATION; RISK; PERCEPTIONS; PROGRAM;
   OBESITY
AB Background: Firefighters are at increased risk of developing cancer due to occupational exposures, but they may also face increased risk due to their lifestyle, such as the quality of their diet and physical activity. Cancer beliefs and screening behavior could also influence their cancer risk. The current study aimed to identify individual differences associated with lifestyle behaviors, cancer screening, and cancer beliefs among firefighters; to describe the strategies firefighters use to adapt to their work schedule; and to describe topics firefighters believe are the most important to address in their workplace.Methods: Career firefighters (N = 171) in a medium-sized U.S. city completed an online survey.Findings: Logistic regression analyses identified age, education, racial identity, years of fire service, perceived stress, and rank as predictors of responses to items addressing cancer screening, lifestyle behaviors, and cancer beliefs. Although results varied, age, education, and racial identity were associated with most of the outcomes. Strategies related to sleep such as getting the right amount and napping, exercise, and getting family/roommate support were selected as the top adaptive strategies for work. Sleep, mental health/well-being, and work-life balance were selected most often as the most important topics to address in the fire service, with topics related to reducing occupational exposures receiving less attention.Conclusions/Application to Practice: The findings suggest individual differences, such as age, education, and racial identity, should be considered when developing occupational health interventions for firefighters. Interventions related to mental health, work-life balance, and sleep may be desired most by those in the fire service.
C1 [Glasgow, Trevin E.] Univ Virginia, Dept Publ Hlth Sci, 200 Jeanette Lancaster Way, Charlottesville, VA 22903 USA.
   [Burch, James B.; Arcan, Chrisa; Fuemmeler, Bernard F.] Virginia Commonwealth Univ, Sch Med, Dept Family Med & Populat Hlth, Richmond, VA USA.
   [Burch, James B.; Arcan, Chrisa; Fuemmeler, Bernard F.] Virginia Commonwealth Univ, Sch Populat Hlth, Richmond, VA USA.
C3 University of Virginia; Virginia Commonwealth University; Virginia
   Commonwealth University
RP Glasgow, TE (corresponding author), Univ Virginia, Dept Publ Hlth Sci, 200 Jeanette Lancaster Way, Charlottesville, VA 22903 USA.
EM trevin@virginia.edu
OI Glasgow, Trevin/0000-0003-2720-3425
FU National Institute of General Medical Sciences [UL1TR002649]; C. Kenneth
   and Dianne Wright Center for Clinical and Translational Research
FX We would like to thank the Richmond Fire and Emergency Services
   Department and Virginia Chapter of the Firefighter Cancer Support
   Network for their help with developing the survey and helping recruit
   participants. We would also like to acknowledge that Virginia
   Commonwealth University REDCap is supported by the C. Kenneth and Dianne
   Wright Center for Clinical and Translational Research grant support
   (UL1TR002649).
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NR 63
TC 0
Z9 0
U1 0
U2 3
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 2165-0799
EI 2165-0969
J9 WORKPLACE HEALTH SAF
JI Workplace Health Saf.
PD JUL
PY 2024
VL 72
IS 7
BP 283
EP 297
DI 10.1177/21650799241254097
EA MAY 2024
PG 15
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA ZZ7H8
UT WOS:001234251000001
PM 38805485
DA 2025-06-11
ER

PT J
AU Pyykkönen, AJ
   Räikkönen, K
   Tuomi, T
   Eriksson, JG
   Groop, L
   Isomaa, B
AF Pyykkonen, Antti-Jussi
   Raikkonen, Katri
   Tuomi, Tiinamaija
   Eriksson, Johan G.
   Groop, Leif
   Isomaa, Bo
TI Stressful Life Events and the Metabolic Syndrome - The Prevalence,
   Prediction and Prevention of Diabetes (PPP)-Botnia Study
SO DIABETES CARE
LA English
DT Article
ID DEPRESSIVE SYMPTOMS; RISK; SLEEP; MORTALITY; DIAGNOSIS; MELLITUS;
   DISEASE; HEALTH; WOMEN; MODEL
AB OBJECTIVE - Stress may play a role in the pathogenesis of the metabolic syndrome. However, the scant evidence available is not population-based, restricting the external validity of the findings. Our aim was to test associations between stressful life events, their accumulation, and the metabolic syndrome in a large population-based cohort. We also tested associations between stress and the individual components related to the metabolic syndrome.
   RESEARCH DESIGN AND METHODS - This was a population-based, random sample of 3,407 women and men aged 18-78 years residing in Western Finland. Metabolic syndrome was defined according to the National Cholesterol Education Program Adult Treatment Panel III and International Diabetes Federation criteria. The severity of 15 stressful life events pertaining to finance, work, social relationships, health, and housing was self-rated.
   RESULTS - in comparison with subjects not reporting any extremely stressful life events, those reporting work- or finance-related events had an increased odds for having the metabolic syndrome. The risk was further increased according to accumulation of stressful finance-related events and to having at least three stressful life events in any of the life domains assessed. Accumulation Of stressful life events was associated with insulin resistance, obesity, and triglycerides. The associations were not confounded by sex, age, lifestyle, or family history of diabetes.
   CONCLUSIONS - Life events perceived as stressful, particularly those related to finance and work, may be a signal for poor metabolic health.
C1 [Pyykkonen, Antti-Jussi; Raikkonen, Katri] Univ Helsinki, Dept Psychol, SF-00100 Helsinki, Finland.
   [Tuomi, Tiinamaija; Eriksson, Johan G.; Isomaa, Bo] Folkhalsan Res Ctr, Helsinki, Finland.
   [Tuomi, Tiinamaija; Groop, Leif] Univ Helsinki, Cent Hosp, Dept Med, Helsinki, Finland.
   [Tuomi, Tiinamaija; Groop, Leif] Univ Helsinki, Res Program Mol Med, Helsinki, Finland.
   [Eriksson, Johan G.] Univ Helsinki, Dept Gen Practice & Primary Hlth Care, Helsinki, Finland.
   [Eriksson, Johan G.] Natl Inst Hlth & Welf, Helsinki, Finland.
   [Eriksson, Johan G.] Univ Helsinki, Cent Hosp, Unit Gen Practice, Helsinki, Finland.
   [Eriksson, Johan G.] Vasa Cent Hosp, Vaasa, Finland.
   [Groop, Leif] Lund Univ, Malmo Univ Hosp, Clin Res Ctr, Dept Clin Sci Diabet & Endocrinol, Malmo, Sweden.
   [Isomaa, Bo] Malmska Municipal Hlth Care Ctr & Hosp, Pietarsaari, Finland.
C3 University of Helsinki; Folkhalsan Research Center; University of
   Helsinki; Helsinki University Central Hospital; University of Helsinki;
   University of Helsinki; Finland National Institute for Health & Welfare;
   University of Helsinki; Helsinki University Central Hospital; Vaasa
   Central Hospital; Lund University; Skane University Hospital
RP Räikkönen, K (corresponding author), Univ Helsinki, Dept Psychol, Fabianinkatu 28, SF-00100 Helsinki, Finland.
EM katri.raikkonen@heisinki.fi
RI Gibbs, J. Raphael/A-3984-2010
OI Raikkonen, Katri/0000-0003-3124-3470; Tuomi,
   Tiinamaija/0000-0002-8306-6202; Eriksson, Johan/0000-0002-2516-2060
FU Sigrid Juselius Foundation; Folkhalsan Research Foundation; Nordic
   Center of Excellence in Disease Genetics; Signe and Ane Gyllenberg
   Foundation; Swedish Cultural Foundation in Finland; Finnish Diabetes
   Research Foundation; Foundation for Life and Health in Finland; Finnish
   Medical Society; Ministry of Education; Paavo Nurmi Foundation; Perklen
   Foundation; Ollqvist Foundation; Narpes Health Care Foundation;
   Municipal Health Care Center and Hospital in Jakobstad, Health Care
   Centers in Vasa, Narpes, and Korsholm
FX The PPP-Botnia study has been supported by grants from the Sigrid
   Juselius Foundation, Folkhalsan Research Foundation, Nordic Center of
   Excellence in Disease Genetics, Signe and Ane Gyllenberg Foundation,
   Swedish Cultural Foundation in Finland, Finnish Diabetes Research
   Foundation, Foundation for Life and Health in Finland, Finnish Medical
   Society, Ministry of Education, Paavo Nurmi Foundation, Perklen
   Foundation, Ollqvist Foundation, and Narpes Health Care Foundation. The
   study has also been supported by the Municipal Health Care Center and
   Hospital in Jakobstad, Health Care Centers in Vasa, Narpes, and
   Korsholm.
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NR 25
TC 84
Z9 101
U1 0
U2 7
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0149-5992
EI 1935-5548
J9 DIABETES CARE
JI Diabetes Care
PD FEB
PY 2010
VL 33
IS 2
BP 378
EP 384
DI 10.2337/dc09-1027
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 563PA
UT WOS:000275143700034
PM 19880581
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Dharavath, RN
   Arora, S
   Bishnoi, M
   Kondepudi, KK
   Chopra, K
AF Dharavath, Ravinder Naik
   Arora, Shiyana
   Bishnoi, Mahendra
   Kondepudi, Kanthi Kiran
   Chopra, Kanwaljit
TI High fat-low protein diet induces metabolic alterations and cognitive
   dysfunction in female rats
SO METABOLIC BRAIN DISEASE
LA English
DT Article
DE Cognitive decline; Fructose feeding; High calorific diet; Hypertension;
   Insulin resistance; Metabolic syndrome
ID INDUCED LIPID-ACCUMULATION; OXIDATIVE STRESS; INDUCED OBESITY;
   INSULIN-RESISTANCE; SERUM-LIPIDS; COCONUT OIL; INFLAMMATION; LIVER;
   CONSUMPTION; IMPAIRMENT
AB Approximately one-third of the world population is suffering from MetS, and the same is expected to rise in the years to come. Worldwide, most of the staple diets contain high amounts of carbohydrates, fats and comparatively low quantities of proteins. The goal of this study was to evaluate the effect of high fat-low protein diet in the development of the metabolic syndrome and associated cognitive deficits in the female rats. The rats fed with high fat-low protein diet (HFLPD) and 15% oral fructose solution for 24 weeks. Body weight, food intake, water intake, fasting blood glucose, oral glucose tolerance, glycosylated hemoglobin (HbA(1C)), and serum lipid profile were measured after every 4 weeks. Serum insulin, HOMA-IR index, rectal temperature, and systolic blood pressure were measured to confirm the manifestation of the hallmarks of metabolic syndrome. Behavioral tests for locomotion, anxiety, learning, and spatial memory were performed from the 12th week to till the end of the study. At the 24th week, oxidative stress assays and histopathology of liver, kidney, brain, and WAT were also performed. HFLPD significantly altered the physiologic and metabolic parameters which contributed to the manifestation of MetS. HFLPD also impaired the cognitive functions along with significant structural changes in the liver, kidney, WAT, and brain. The findings of this study reveal that HFLPD has the potential to induce the physiological, metabolic and histological alterations in rats, which eventually led to the development of MetS and also disrupted the cognitive functions in female rats.
C1 [Dharavath, Ravinder Naik; Arora, Shiyana; Chopra, Kanwaljit] Panjab Univ, Pharmacol Res Lab, UIPS, Chandigarh 160014, India.
   [Bishnoi, Mahendra; Kondepudi, Kanthi Kiran] Natl Agri Food Biotechnol Inst NABI, Food & Nutr Biotechnol Lab, Sas Nagar 140306, Punjab, India.
C3 Panjab University; Department of Biotechnology (DBT) India; National
   Agri Food Biotechnology Institute (NABI)
RP Chopra, K (corresponding author), Panjab Univ, Pharmacol Res Lab, UIPS, Chandigarh 160014, India.
EM dr_chopra_k@yahoo.com
RI Kondepudi, Kanthi/P-8336-2014; Dharavath, Ravinder Naik/AAB-9469-2019;
   Bishnoi, Mahendra/CAG-3229-2022
OI Dharavath, Ravinder Naik/0000-0002-2356-2458; Chopra,
   Kanwaljit/0000-0001-5898-6093; Kondepudi, Kanthi
   Kiran/0000-0001-8036-7555; Bishnoi, Mahendra/0000-0002-7785-1204
FU University Grants Commission, New Delhi, India
FX The authors duly acknowledge the University Grants Commission, New
   Delhi, India for providing UGC-BSR-RFSMS fellowship to Ravinder Naik
   Dharavath and Panjab University, Chandigarh for providing research
   facilities.
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NR 58
TC 17
Z9 19
U1 1
U2 15
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0885-7490
EI 1573-7365
J9 METAB BRAIN DIS
JI Metab. Brain Dis.
PD DEC
PY 2019
VL 34
IS 6
BP 1531
EP 1546
DI 10.1007/s11011-019-00459-4
PG 16
WC Endocrinology & Metabolism; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology
GA JN1LR
UT WOS:000496665000002
PM 31313125
DA 2025-06-11
ER

PT J
AU Andres-Hernando, A
   Lanaspa, MA
   Kuwabara, M
   Orlicky, DJ
   Cicerchi, C
   Bales, E
   Garcia, GE
   Roncal-Jimenez, CA
   Sato, Y
   Johnson, RJ
AF Andres-Hernando, Ana
   Lanaspa, Miguel A.
   Kuwabara, Masanari
   Orlicky, David J.
   Cicerchi, Christina
   Bales, Elise
   Garcia, Gabriela E.
   Roncal-Jimenez, Carlos A.
   Sato, Yuka
   Johnson, Richard J.
TI Obesity causes renal mitochondrial dysfunction and energy imbalance and
   accelerates chronic kidney disease in mice
SO AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
LA English
DT Article
DE chronic kidney disease; mitochondria; obesity; renal energy; sarcopenia
ID OXIDATIVE STRESS; (-)-EPICATECHIN; PREVALENCE; BIOGENESIS; MECHANISMS;
   PROTEIN; INJURY
AB Obesity and metabolic syndrome are well-known risk factors for chronic kidney disease (CKD); however, less is known about the mechanism(s) by which metabolic syndrome might accelerate kidney disease. We hypothesized that metabolic syndrome should accelerate the development of kidney disease and that it might be associated with alterations in energy metabolism. We studied the pound mouse (which develops early metabolic syndrome due to a leptin receptor deletion) and wild-type littermates and compared the level of renal injury and muscle wasting after equivalent injury with oral adenine. Renal function, histology, and biochemical analyses were performed. The presence of metabolic syndrome was associated with earlier development of renal disease (12 mo) and earlier mortality in pound mice compared with controls. After administration of adenine, kidney disease was worse in pound mice, and this was associated with greater tubular injury with a decrease in kidney mitochondria, lower tissue ATP levels, and worse oxidative stress. Pound mice with similar levels of renal function as adenine-treated wild-type mice also showed worse sarcopenia, with lower tissue ATP and intracellular phosphate levels. In summary, our data demonstrate that obesity and metabolic syndrome accelerate the progression of CKD and worsen CKD-dependent sarcopenia. Both conditions are associated with renal alterations in energy metabolism and lower tissue ATP levels secondary to mitochondrial dysfunction and reduced mitochondrial number.
C1 [Andres-Hernando, Ana; Lanaspa, Miguel A.; Kuwabara, Masanari; Cicerchi, Christina; Garcia, Gabriela E.; Roncal-Jimenez, Carlos A.; Sato, Yuka; Johnson, Richard J.] Rocky Mt Reg Vet Affairs Med Ctr, Div Renal Dis, Aurora, CO USA.
   [Andres-Hernando, Ana; Lanaspa, Miguel A.; Kuwabara, Masanari; Cicerchi, Christina; Garcia, Gabriela E.; Roncal-Jimenez, Carlos A.; Sato, Yuka; Johnson, Richard J.] Univ Colorado, Div Renal Dis & Hypertens, Anschutz Med Campus, Denver, CO 80202 USA.
   [Kuwabara, Masanari] Toranomon Gen Hosp, Dept Cardiol, Tokyo, Japan.
   [Orlicky, David J.] Univ Colorado, Dept Pathol, Anschutz Med Campus, Aurora, CO 80045 USA.
   [Bales, Elise] Univ Colorado, Div Reprod Sci, Anschutz Med Campus, Aurora, CO 80045 USA.
C3 University of Colorado System; University of Colorado Denver; University
   of Colorado Anschutz Medical Campus; Toranomon Hospital; University of
   Colorado System; University of Colorado Anschutz Medical Campus;
   University of Colorado System; University of Colorado Anschutz Medical
   Campus
RP Lanaspa, MA (corresponding author), Univ Colorado, Dept Med, Div Renal Dis & Hypertens, 12700 E 19th Ave,Box C-281, Aurora, CO 80045 USA.
EM miguel.lanaspagarcia@cuanschutz.edu
RI Lanaspa, Miguel/AAO-4971-2020; Kuwabara, Masanari/O-9844-2017
OI Kuwabara, Masanari/0000-0002-6601-4347; Lanaspa,
   Miguel/0000-0002-1163-1831; Johnson, Richard/0000-0003-3312-8193;
   Andres-Hernando, Ana/0000-0002-0676-0188
FU Veteran Affairs Merit Awards [1IO1BX002586, 1IO1BX004511-01]
FX This work was supported by Veteran Affairs Merit Awards 1IO1BX002586 and
   1IO1BX004511-01 (to R. J. Johnson).
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NR 31
TC 34
Z9 35
U1 0
U2 20
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 1931-857X
EI 1522-1466
J9 AM J PHYSIOL-RENAL
JI Am. J. Physiol.-Renal Physiol.
PD OCT
PY 2019
VL 317
IS 4
BP F941
EP F948
DI 10.1152/ajprenal.00203.2019
PG 8
WC Physiology; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology; Urology & Nephrology
GA JD4KX
UT WOS:000489947900017
PM 31411075
OA Bronze
DA 2025-06-11
ER

PT J
AU Yamagata, K
AF Yamagata, Kazuo
TI Do Coffee Polyphenols Have a Preventive Action on Metabolic Syndrome
   Associated Endothelial Dysfunctions? An Assessment of the Current
   Evidence
SO ANTIOXIDANTS
LA English
DT Review
DE antioxidative effects; chlorogenic acid; endothelial dysfunction;
   metabolic syndrome
ID NONALCOHOLIC FATTY LIVER; DOSE-RESPONSE METAANALYSIS; OXIDATIVE STRESS;
   CHLOROGENIC ACID; TEA CONSUMPTION; CARDIOVASCULAR-DISEASE; RISK-FACTORS;
   DECAFFEINATED COFFEE; INSULIN-RESISTANCE; VASCULAR-DISEASE
AB Epidemiologic studies from several countries have found that mortality rates associated with the metabolic syndrome are inversely associated with coffee consumption. Metabolic syndrome can lead to arteriosclerosis by endothelial dysfunction, and increases the risk for myocardial and cerebral infarction. Accordingly, it is important to understand the possible protective effects of coffee against components of the metabolic syndrome, including vascular endothelial function impairment, obesity and diabetes. Coffee contains many components, including caffeine, chlorogenic acid, diterpenes and trigonelline. Studies have found that coffee polyphenols, such as chlorogenic acids, have many health-promoting properties, such as antioxidant, anti-inflammatory, anti-cancer, anti-diabetes, and antihypertensive properties. Chlorogenic acids may exert protective effects against metabolic syndrome risk through their antioxidant properties, in particular toward vascular endothelial cells, in which nitric oxide production may be enhanced, by promoting endothelial nitric oxide synthase expression. These effects indicate that coffee components may support the maintenance of normal endothelial function and play an important role in the prevention of metabolic syndrome. However, results related to coffee consumption and the metabolic syndrome are heterogeneous among studies, and the mechanisms of its functions and corresponding molecular targets remain largely elusive. This review describes the results of studies exploring the putative effects of coffee components, especially in protecting vascular endothelial function and preventing metabolic syndrome.
C1 [Yamagata, Kazuo] Nihon Univ, Coll Bioresource Sci NUBS, Dept Food Biosci & Biotechnol, Lab Mol Hlth Sci Food, 1866 Kameino, Fujisawa, Kanagawa 2528510, Japan.
C3 Nihon University
RP Yamagata, K (corresponding author), Nihon Univ, Coll Bioresource Sci NUBS, Dept Food Biosci & Biotechnol, Lab Mol Hlth Sci Food, 1866 Kameino, Fujisawa, Kanagawa 2528510, Japan.
EM kyamagat@brs.nihon-u.ac.jp
FU Grants-in-Aid for Scientific Research [15K08321] Funding Source: KAKEN
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NR 100
TC 54
Z9 56
U1 1
U2 25
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD FEB
PY 2018
VL 7
IS 2
AR 26
DI 10.3390/antiox7020026
PG 18
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA FZ3QR
UT WOS:000427505500005
PM 29401716
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Ramalho, FN
   Sanches, SC
   Foss, MC
   Augusto, MJ
   Silva, DM
   Oliveira, AM
   Ramalho, LN
AF Ramalho, F. N.
   Sanches, S. C.
   Foss, M. C.
   Augusto, M. J.
   Silva, D. M.
   Oliveira, A. M.
   Ramalho, L. N.
TI Aliskiren effect on non-alcoholic steatohepatitis in metabolic syndrome
SO DIABETOLOGY & METABOLIC SYNDROME
LA English
DT Article
DE Diabetes mellitus; Nonalcoholic steatohepatitis; Metabolic syndrome;
   Aliskiren
ID RENIN-ANGIOTENSIN SYSTEM; IMPROVES INSULIN-RESISTANCE; TYPE-1 RECEPTOR
   BLOCKER; FATTY LIVER-DISEASE; BILE-DUCT LIGATION; OXIDATIVE STRESS;
   HEPATIC-FIBROSIS; VASCULAR COMPLICATIONS; RATS; MICE
AB Background: Non-alcoholic steatohepatitis (NASH) is highly associated with metabolic syndrome, a major cause of morbidity in the globalized society. The renin-angiotensin system (RAS) influences hepatic fatty acid metabolism, inflammation and fibrosis. Thus, in the present study, we aimed to evaluate the effect of aliskiren, a direct renin inhibitor, on metabolic syndrome-related NASH.
   Methods: C57BL/6 male mice (n = 45) were divided into three groups: controls; animals inoculated with streptozotocin (STZ) (40 mg/kg/day) for 5 days and fed with high fat diet (HFD) for 8 weeks; and animals inoculated with STZ for 5 days, fed with HFD for 8 weeks and treated with aliskiren (100 mg/kg/day) for the final 2 weeks. Glycemic and insulin levels, hepatic lipid profile, histological parameters and inflammatory protein expression were analyzed.
   Results: Aliskiren normalized plasma glucose and insulin levels, reduced cholesterol, triglycerides and total fat accumulation in liver and diminished hepatic injury, steatosis and fibrosis. These results could be explained by the ability of aliskiren to block angiotensin-II, lowering oxidative stress and inflammation in liver. Also, it exhibited a beneficial effect in increasing insulin sensitivity.
   Conclusion: These findings support the use of aliskiren in the treatment of metabolic syndrome underlying conditions. However, clinical studies are indispensable to test its effectiveness in the treatment of patients with metabolic syndrome.
C1 [Ramalho, F. N.; Sanches, S. C.; Augusto, M. J.; Silva, D. M.; Ramalho, L. N.] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Pathol & Legal Med, BR-14049900 Ribeirao Preto, SP, Brazil.
   [Foss, M. C.] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Med, Ribeirao Preto, SP, Brazil.
   [Oliveira, A. M.] Univ Sao Paulo, Fac Pharmaceut Sci Ribeirao Preto, Dept Chem & Phys, Ribeirao Preto, SP, Brazil.
C3 Universidade de Sao Paulo; Universidade de Sao Paulo; Universidade de
   Sao Paulo
RP Ramalho, LN (corresponding author), Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Pathol & Legal Med, BR-14049900 Ribeirao Preto, SP, Brazil.
EM lramalho@fmrp.usp.br
RI Ramalho, Leandra/A-3983-2010; Sanches, Sheila/K-9334-2015; Oliveira,
   Alisson/AIA-9715-2022; Foss-Freitas, Maria/F-1197-2013
OI Naira Zambelli Ramalho, Fernanda/0000-0003-1836-2352; Ramalho,
   Leandra/0000-0002-3486-5294
FU FAPESP [2010/20895-4]; CNPq [160028/2012-4]; FAEPA
FX This work was supported by grants from FAPESP-no 2010/20895-4, CNPq-no
   160028/2012-4 and FAEPA.
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NR 46
TC 7
Z9 7
U1 0
U2 9
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1758-5996
J9 DIABETOL METAB SYNDR
JI Diabetol. Metab. Syndr.
PD OCT 13
PY 2017
VL 9
AR 82
DI 10.1186/s13098-017-0282-5
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA FJ6XI
UT WOS:000412900900003
PM 29046730
OA Green Published, gold
DA 2025-06-11
ER

EF﻿FN Clarivate Analytics Web of Science
VR 1.0
PT J
AU Barbagallo, M
   Veronese, N
   Dominguez, LJ
AF Barbagallo, Mario
   Veronese, Nicola
   Dominguez, Ligia J.
TI Magnesium in Aging, Health and Diseases
SO NUTRIENTS
LA English
DT Review
DE magnesium; oxidative stress; diseases; dementia; diabetes; osteoporosis;
   aging; hypertension; health; longevity
ID SUPPRESSES BONE TURNOVER; TRACE-ELEMENT LEVELS; TRANS-ACONITIC ACID;
   C-REACTIVE PROTEIN; DIETARY MAGNESIUM; SERUM MAGNESIUM; BLOOD-PRESSURE;
   METABOLIC SYNDROME; DOUBLE-BLIND; DIABETES-MELLITUS
AB Several changes of magnesium (Mg) metabolism have been reported with aging, including diminished Mg intake, impaired intestinal Mg absorption and renal Mg wasting. Mild Mg deficits are generally asymptomatic and clinical signs are usually non-specific or absent. Asthenia, sleep disorders, hyperemotionality, and cognitive disorders are common in the elderly with mild Mg deficit, and may be often confused with age-related symptoms. Chronic Mg deficits increase the production of free radicals which have been implicated in the development of several chronic age-related disorders. Numerous human diseases have been associated with Mg deficits, including cardiovascular diseases, hypertension and stroke, cardio-metabolic syndrome and type 2 diabetes mellitus, airways constrictive syndromes and asthma, depression, stress-related conditions and psychiatric disorders, Alzheimer's disease (AD) and other dementia syndromes, muscular diseases (muscle pain, chronic fatigue, and fibromyalgia), bone fragility, and cancer. Dietary Mg and/or Mg consumed in drinking water (generally more bioavailable than Mg contained in food) or in alternative Mg supplements should be taken into consideration in the correction of Mg deficits. Maintaining an optimal Mg balance all through life may help in the prevention of oxidative stress and chronic conditions associated with aging. This needs to be demonstrated by future studies.
C1 [Barbagallo, Mario; Veronese, Nicola; Dominguez, Ligia J.] Univ Palermo, Dept Med, Geriatr Unit, I-90127 Palermo, Italy.
C3 University of Palermo
RP Barbagallo, M (corresponding author), Univ Palermo, Dept Med, Geriatr Unit, I-90127 Palermo, Italy.
EM mario.barbagallo@unipa.it; nicola.veronese@unipa.it;
   ligia.dominguez@unipa.it
RI Veronese, Nicola/K-4343-2018; BARBAGALLO, MARIO/K-4794-2017
OI BARBAGALLO, MARIO/0000-0002-1349-6530
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NR 186
TC 201
Z9 221
U1 22
U2 159
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD FEB
PY 2021
VL 13
IS 2
AR 463
DI 10.3390/nu13020463
PG 20
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nutrition & Dietetics
GA QO2FV
UT WOS:000622961600001
PM 33573164
OA gold, Green Published
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Kanbay, M
   Solak, Y
   Dogan, E
   Lanaspa, MA
   Covic, A
AF Kanbay, Mehmet
   Solak, Yalcin
   Dogan, Ekrem
   Lanaspa, Miguel A.
   Covic, Adrian
TI Uric Acid in Hypertension and Renal Disease: The Chicken or the Egg?
SO BLOOD PURIFICATION
LA English
DT Review
DE Hypertension; Renal disease; Uric acid
ID CHRONIC-KIDNEY-DISEASE; BLOOD-PRESSURE; GLOMERULAR HYPERTENSION;
   CARDIOVASCULAR RISK; MILD HYPERURICEMIA; ENDOTHELIAL DYSFUNCTION;
   INDEPENDENT MECHANISM; CARDIOMETABOLIC RISK; METABOLIC SYNDROME;
   OXIDATIVE STRESS
AB After uric acid was recognized as the causative factor in gout, increased prevalence of renal disease and hypertension in this patient population caught the attention of the medical community. Thus, it has been proposed that uric acid might have caused these disorders. However, uric acid suffered a long period of ignorance in which it was considered a metabolically inert substance. However, recent years has witnessed a resurrection of interest. Experimental studies showed an association between increased uric acid and renal arteriolar disease and hypertension. These preliminary results were supported with clinical studies. However, controversy regarding the precise pathophysiologic role of uric acid in inducing hypertension and renal disease remains to be elucidated. Despite being limited at this time, a few randomized intervention studies showed that even treatment of asymptomatic hyperuricemia was beneficial in terms of blood pressure regulation and kidney function. In this review, we focus on the pathophysiologic role of uric acid in the development and progression of renal disease and hypertension. We also discuss recent clinical evidence suggesting a causal role of uric acid in these disease states. Copyright (C) 2010 S. Karger AG, Basel
C1 [Kanbay, Mehmet] Gulhane Mil Med Acad, Dept Med, Div Nephrol, Ankara, Turkey.
   [Solak, Yalcin] Selcuk Univ, Meram Sch Med, Dept Med, Div Nephrol, Konya, Turkey.
   [Dogan, Ekrem] Sutcu Imam Univ, Sch Med, Dept Med, Div Nephrol, Kahramanmaras, Turkey.
   [Lanaspa, Miguel A.] Univ Colorado, Div Renal Dis & Hypertens, Denver, CO 80202 USA.
   [Covic, Adrian] Gr T Popa Univ Med & Pharm, CI Parhon Univ Hosp, Nephrol Clin, Dialysis & Renal Transplant Ctr, Iasi, Romania.
C3 Gulhane Military Medical Academy; Selcuk University; Kahramanmaras Sutcu
   Imam University; University of Colorado System; University of Colorado
   Denver; National Institute of Endocrinology C.I. Parhon; Grigore T Popa
   University of Medicine & Pharmacy
RP Kanbay, M (corresponding author), Umit Sokak 25-14, Kayseri, Turkey.
EM drkanbay@yahoo.com
RI Solak, Yalcin/AAD-1393-2020; 1, 1/L-6277-2019; Covic,
   Adrian/G-5017-2016; Lanaspa, Miguel/AAO-4971-2020
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NR 70
TC 60
Z9 70
U1 0
U2 15
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0253-5068
EI 1421-9735
J9 BLOOD PURIFICAT
JI Blood Purif.
PY 2010
VL 30
IS 4
BP 288
EP 295
DI 10.1159/000321074
PG 8
WC Hematology; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Hematology; Urology & Nephrology
GA 701KO
UT WOS:000285817000006
PM 21088389
OA Bronze
DA 2025-06-11
ER

PT J
AU Khanal, MK
   Karimi, L
   Saunders, P
   Schneider, RH
   Salerno, J
   Livesay, K
   Hallam, KT
   de Courten, B
AF Khanal, Mahesh Kumar
   Karimi, Leila
   Saunders, Peter
   Schneider, Robert H.
   Salerno, John
   Livesay, Karen
   Hallam, Karen T.
   de Courten, Barbora
TI The promising role of Transcendental Meditation in the prevention and
   treatment of cardiometabolic diseases: A systematic review
SO OBESITY REVIEWS
LA English
DT Review
DE blood pressure (BP); cardiovascular diseases (CVD); dyslipidemia;
   hypertension; insulin resistance; metabolic syndrome (MS); obesity
ID RANDOMIZED CONTROLLED-TRIAL; LOWERING BLOOD-PRESSURE; STRESS REDUCTION;
   CARDIOVASCULAR-DISEASE; AFRICAN-AMERICANS; HEALTH-EDUCATION; PROGRAM;
   HYPERTENSION; METAANALYSIS; PRACTITIONERS
AB Psychological distress has a demonstrable impact on cardiovascular diseases (CVD) and risk factors. Transcendental Meditation (TM) has been shown to reduce stress and improve health and well-being. The current review aimed to synthesize the evidence on the effects of TM on cardiometabolic outcomes and identify gaps for future research. We searched PubMed/MEDLINE, EMBASE, SCOPUS, and Web of Science databases for relevant literature. Forty-five papers that reported studies of TM on cardiometabolic risk factors and diseases were included. Evidence shows that TM is effective in reducing blood pressure (BP). We found some evidence that TM can improve insulin resistance and may play a role in improving dyslipidemia, exercise tolerance, and myocardial blood flow, and in reducing carotid intima-media thickness and left ventricular mass. Studies show that long-term TM practice can reduce the risk of myocardial infarction, stroke, and CVD mortality. This review identified that certain studies have high participant drop-out rates, and fewer studies targeted comprehensive cardiometabolic outcomes beyond BP with longer follow-up periods. We found that most studies were conducted in specific populations, which may limit generalizability. In conclusion, TM has the potential to improve cardiometabolic health; however, research gaps highlight the need for larger phase III multicenter clinical trials with long-term follow-ups.
C1 [Khanal, Mahesh Kumar; Karimi, Leila; Saunders, Peter; Livesay, Karen; Hallam, Karen T.; de Courten, Barbora] RMIT Univ, Sch Hlth & Biomed Sci, Melbourne, Vic, Australia.
   [Schneider, Robert H.] Maharishi Int Univ, Coll Integrat Med, Fairfield, IA USA.
   [Schneider, Robert H.; Salerno, John] Inst Prevent Res, Vedic City, LA USA.
   [de Courten, Barbora] Monash Univ, Sch Clin Sci Monash Hlth, Dept Med, Melbourne, Vic, Australia.
C3 Royal Melbourne Institute of Technology (RMIT); Monash University
RP de Courten, B (corresponding author), RMIT Univ, Sch Hlth & Biomed Sci, Bundoora, Australia.
EM barbora.decourten@rmit.edu.au
RI Karimi, Leila/AFN-2380-2022; de Courten, Barbora/B-3308-2012
OI de Courten, Barbora/0000-0001-8760-2511; Hallam,
   Karen/0000-0003-0495-5341; Khanal, Dr. Mahesh Kumar/0000-0001-5324-2802;
   LIVESAY, KAREN/0000-0002-6837-8005
FU School of Health and Biomedical Sciences at RMIT University, Bundoora,
   Australia; NIH-NCCIH grant [P50-AT000082]
FX This systematic review was supported by the School of Health and
   Biomedical Sciences at RMIT University, Bundoora, Australia. It also
   received partial support from NIH-NCCIH grant # P50-AT000082 awarded to
   RHS. Open access publishing facilitated by RMIT University, as part of
   the Wiley - RMIT University agreement via the Council of Australian
   University Librarians.
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NR 103
TC 3
Z9 3
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1467-7881
EI 1467-789X
J9 OBES REV
JI Obes. Rev.
PD OCT
PY 2024
VL 25
IS 10
DI 10.1111/obr.13800
EA JUL 2024
PG 24
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA E5Y8P
UT WOS:001278706000001
PM 39072971
OA hybrid
DA 2025-06-11
ER

PT J
AU Artham, SM
   Lavie, CJ
   Milani, RV
AF Artham, Surya M.
   Lavie, Carl J.
   Milani, Richard V.
TI Cardiac rehabilitation programs markedly improve high-risk profiles in
   coronary patients with high psychological distress
SO SOUTHERN MEDICAL JOURNAL
LA English
DT Article
DE cardiopulmonary rehabilitation; coronary artery disease; depression;
   hostility; psychological distress
ID ACUTE MYOCARDIAL-INFARCTION; EXERCISE TRAINING-PROGRAMS; HEART-DISEASE;
   ARTERY-DISEASE; PSYCHOSOCIAL FACTORS; METABOLIC SYNDROME; VENTRICULAR
   REPOLARIZATION; PHOBIC ANXIETY; 52 COUNTRIES; DEPRESSION
AB Objectives: Adverse behavioral profiles, particularly depression and hostility, increase the risk of coronary artery disease (CAD) and affect recovery after CAD events. We sought to determine the effects of outpatient phase II cardiac rehabilitation and exercise training (CRET) programs in CAD patients with high levels of psychological distress.
   Methods: We studied 500 consecutive patients both before and after phase II CRET programs and compared 109 patients with the highest quintile of psychological distress (HD) with 115 patients with the lowest quintile of psychological distress (LD).
   Results: At baseline, patients with HD were younger (P < 0.001), bad higher weight (+ 11%; P < 0.001), body mass indices (BMI) (+ 9%; P < 0.01), triglycerides (+ 66%; P < 0.0001), and glycosylated hemoglobin (+ 9%; P = 0.03), and had higher scores for depression, hostility, anxiety, and somatization (all P < 0.0001), but had lower values for exercise capacity(-15%; P = 0.02), high-density lipoprotein (HDL) cholesterol (-10%; P < 0.01), and total quality of life (QoL) (-26%; P < 0.0001), and all 6 major components of QoL compared with LD. After CRET, patients with HD had significant reductions in weight (-2%; P < 0.01), % fat (-6%; P < 0.001), BMI (-2%, P < 0.01), and scores for anxiety (-49%), depression (-47%), somatization (-34%) and hostility (-38%) (all P < 0.0001), and increases in exercise capacity (+ 54%; P < 0.0001), HDL cholesterol (+ 10%; P < 0.0001), and total QoL (+ 23%; P < 0.0001), and the 6 components of QoL studied. Compared with patients with LD, those with HD had statistically greater improvements in HDL (P = 0.03), triglycerides (P = 0.03), BM I (P = 0.02), as well as all behavioral characteristics and QoL (P < 0.0001), and had similar improvements in all other factors assessed.
   Conclusions: These data support the routine assessment of high-risk behavioral characteristics in patients with CAD and demonstrate the marked improvements that occur after phase II CRET programs in CAD patients with high psychological distress.
C1 [Artham, Surya M.; Lavie, Carl J.; Milani, Richard V.] Ochsner Med Ctr, Exercise Labs, New Orleans, LA 70121 USA.
C3 Ochsner Health System
RP Lavie, CJ (corresponding author), Ochsner Med Ctr, Exercise Labs, 1514 Jefferson Highway, New Orleans, LA 70121 USA.
EM clavie@ochsner.org
RI Lavie, Carl/A-6014-2011; Milani, Richard/AAS-7955-2020
CR [Anonymous], JAMA
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NR 49
TC 33
Z9 40
U1 1
U2 8
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0038-4348
J9 SOUTH MED J
JI South.Med.J.
PD MAR
PY 2008
VL 101
IS 3
BP 262
EP 267
DI 10.1097/SMJ.0b013e318164dfa8
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 272OI
UT WOS:000253868700017
PM 18364656
DA 2025-06-11
ER

PT J
AU Jiang, XW
   Li, XS
   Zhu, CJ
   Sun, JX
   Tian, LM
   Chen, W
   Bai, WB
AF Jiang, Xinwei
   Li, Xusheng
   Zhu, Cuijuan
   Sun, Jianxia
   Tian, Lingmin
   Chen, Wei
   Bai, Weibin
TI The target cells of anthocyanins in metabolic syndrome
SO CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
LA English
DT Article; Proceedings Paper
CT 3rd International Symposium on Phytochemicals in Medicine and Food
   (ISPMF)
CY AUG 25-30, 2018
CL Kunming, PEOPLES R CHINA
SP Phytochem Soc Europe, Int Soc Chinese Med, Physiol Soc Japan, Phytochem Soc Asia
DE Anthocyanins; cyanidin-3-O-glucoside; cardiovascular disease; diabetes;
   obesity; nonalcoholic fatty liver disease; metabolic syndrome;
   intestinal microbiota
ID BLACK-CURRANT ANTHOCYANINS; INDUCED OXIDATIVE STRESS; FATTY
   LIVER-DISEASE; ENDOPLASMIC-RETICULUM STRESS; INTESTINAL
   EPITHELIAL-CELLS; INDUCED INSULIN-RESISTANCE; HEPATIC BIOMARKER LEVELS;
   LOW-GRADE INFLAMMATION; RICH BILBERRY EXTRACT; SWEET-POTATO BEVERAGE
AB Metabolic syndrome develops to several related chronic diseases, such as obesity, cardiovascular disease, hypertension, diabetes, and fatty liver disease. Diseases are outcomes of various cells dysfunction, which are especially acting with a network in metabolic syndrome. Anthocyanins are natural edible pigments widely existed in dark-colored fruits, vegetables, and grains. Epidemiological investigation and nutritional intervention of anthocyanins have exhibited broad-spectrum biological effects that they can benefit patients with metabolic syndrome related chronic diseases. Whereas the underlying mechanisms and the effects of anthocyanins on critical cells in chronic metabolic diseases are complex and elusive. Therefore, this review summarizes the studies about the effects of anthocyanins on various metabolism related chronic diseases, and mainly focuses on the effects and underlying molecular mechanisms on critical cells. We confirmed that anthocyanins are efficient on adipocytes, endothelial cells, inflammatory cells, hepatocytes, intestinal cells and gut microbiota, but lack of evidence on platelets, skeletal muscle cells, hepatic stellate cells and pancreatic beta cells. Additionally, we discussed the structure-function relationship of anthocyanins and the metabolites. This review summarizes the development of studies on anthocyanins with its target cells in metabolic syndrome, and discusses the unclear aspects of the anthocyanins research work, which is necessary for the future clinical application.
C1 [Jiang, Xinwei; Li, Xusheng; Zhu, Cuijuan; Tian, Lingmin; Bai, Weibin] Jinan Univ, Inst Food Safety & Nutr, Guangdong Engn Technol Ctr Food Safety Mol Rapid, Dept Food Sci & Engn, Guangzhou, Guangdong, Peoples R China.
   [Sun, Jianxia] Guangdong Univ Technol, Sch Chem Engn & Light Ind, Guangzhou, Guangdong, Peoples R China.
   [Chen, Wei] Jiangnan Univ, State Key Lab Food Sci & Technol, Sch Food Sci & Technol, Wuxi, Peoples R China.
C3 Jinan University; Guangdong University of Technology; Jiangnan
   University
RP Bai, WB (corresponding author), Jinan Univ, Inst Sci & Technol, Inst Food Safety & Nutr, Dept Food Sci & Engn, 601 Huangpu Rd, Guangzhou 510632, Guangdong, Peoples R China.
EM baiweibin@163.com
RI Li, Xusheng/O-3615-2019; TIAN, LINGMIN/AAH-1449-2020
OI Li, Xusheng/0000-0003-3339-685X
FU National Natural Science Foundation of China (NSFC) [31771983, 31871816,
   81703211]; Science and Technology Program of Guangzhou [201704020050];
   Chinese Postdoctoral Science Foundation [2016M602608]
FX This study was supported by the National Natural Science Foundation of
   China (NSFC, No. 31771983, No. 31871816 and No. 81703211). The authors
   also thank the Science and Technology Program of Guangzhou (No.
   201704020050) and Chinese Postdoctoral Science Foundation (No.
   2016M602608)
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NR 233
TC 78
Z9 79
U1 1
U2 187
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1040-8398
EI 1549-7852
J9 CRIT REV FOOD SCI
JI Crit. Rev. Food Sci. Nutr.
PD MAR 26
PY 2019
VL 59
IS 6
SI SI
BP 921
EP 946
DI 10.1080/10408398.2018.1491022
PG 26
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Food Science & Technology; Nutrition & Dietetics
GA HX9OX
UT WOS:000467738800007
PM 29993258
DA 2025-06-11
ER

PT J
AU Fourrier, C
   Kropp, C
   Aubert, A
   Sauvant, J
   Vaysse, C
   Chardigny, JM
   Layé, S
   Joffre, C
   Castanon, N
AF Fourrier, Celia
   Kropp, Camille
   Aubert, Agnes
   Sauvant, Julie
   Vaysse, Carole
   Chardigny, Jean-Michel
   Laye, Sophie
   Joffre, Corinne
   Castanon, Nathalie
TI Rapeseed oil fortified with micronutrients improves cognitive
   alterations associated with metabolic syndrome
SO BRAIN BEHAVIOR AND IMMUNITY
LA English
DT Article
DE n-3 PUFAS; Antioxidants; Metabolic syndrome; Obesity; Inflammation;
   Anxiety; Memory; Hippocampus; Glutamatergic receptors; Db/db mice
ID DEPRESSIVE-LIKE BEHAVIOR; POLYUNSATURATED FATTY-ACIDS; LONG-TERM
   POTENTIATION; SPATIAL MEMORY; SYNAPTIC PLASTICITY; MOUSE MODEL;
   MEDITERRANEAN DIET; INDOLEAMINE 2,3-DIOXYGENASE; MICROGLIAL CELLS; NMDA
   RECEPTORS
AB Metabolic syndrome represents a major risk factor for severe comorbidities such as cardiovascular diseases or diabetes. It is also associated with an increased prevalence of emotional and cognitive alterations that in turn aggravate the disease and related outcomes. Identifying therapeutic strategies able to improve those alterations is therefore a major socioeconomical and public health challenge. We previously reported that both hippocampal inflammatory processes and neuronal plasticity contribute to the development of emotional and cognitive alterations in db/db mice, an experimental model of metabolic syndrome that displays most of the classical features of the syndrome. In that context, nutritional interventions with known impact on those neurobiological processes appear as a promising alternative to limit the development of neurobiological comorbidities of metabolic syndrome. We therefore tested here whether n-3 polyunsaturated fatty acids (n-3 PUFAs) associated with a cocktail of antioxidants can protect against the development of behavioral alterations that accompany the metabolic syndrome. Thus, this study aimed: 1) to evaluate if a diet supplemented with the plant-derived n-3 PUFA alpha-linolenic acid (ALA) and antioxidants (provided by n-3 PUFAs-rich rapeseed oil fortified with a mix of naturally constituting antioxidant micronutrients, including coenzyme Q10, tocopherol, and the phenolic compound canolol) improved behavioral alterations in db/db mice, and 2) to decipher the biological mechanisms underlying this behavioral effect. Although the supplemented diet did not improve anxiety-like behavior and inflammatory abnormalities, it reversed hippocampus-dependent spatial memory deficits displayed by db/db mice in a water maze task. It concomitantly changed subunit composition of glutamatergic AMPA and NMDA receptors in the hippocampus that has been shown to modulate synaptic function related to spatial memory. These data suggest that changes in local neuronal plasticity may underlie cognitive improvements in db/db mice fed the supplemented diet. The current findings might therefore provide valuable data for introducing new nutritional strategies for the treatment of behavioral complications associated with MetS.
C1 [Fourrier, Celia; Kropp, Camille; Aubert, Agnes; Sauvant, Julie; Laye, Sophie; Joffre, Corinne; Castanon, Nathalie] Univ Bordeaux, INRA, Bordeaux INP, NutriNeuro,UMR 1286, F-33000 Bordeaux, France.
   [Vaysse, Carole] Inst Corps Gras, ITERG, F-33600 Pessac, France.
   [Chardigny, Jean-Michel] Univ Clermont Ferrand, CRNH Auvergne, Unite Nutr Humaine, INRA, F-63000 Clermont Ferrand, France.
   [Chardigny, Jean-Michel] INRA Bourgogne Franche Comte, Ctr Rech, F-21065 Dijon, France.
C3 Universite de Bordeaux; INRAE; Institut National de la Sante et de la
   Recherche Medicale (Inserm); INRAE; INRAE
RP Castanon, N (corresponding author), Univ Bordeaux, INRA, UMR 1286, Nutr & Neurobiol Integree, Batiment UFR Pharm,2 Tranche,2 Etage, F-33076 Bordeaux, France.
EM nathalie.castanon@inra.fr
RI SAUVANT, Julie/AAK-3263-2021; Laye, Sophie/AAX-2501-2020
OI Castanon, Nathalie/0000-0002-0079-0562; Fourrier,
   Celia/0000-0003-1505-1559; Laye, Sophie/0000-0002-3843-1012; KROPP,
   Camille/0000-0001-7650-9506
FU French Government [ANR-001-01]; Institut National de la Recherche
   Agronomique (INRA, France); Region Aquitaine; INRA (Departement de
   Nutrition Humaine) [22000763]; LABEX BRAIN (France)
FX This work was performed, in partnership with the SAS PIVERT, within the
   frame of the French Institute for the Energy Transition (Institut pour
   la Transition Energetique, ITE) P.I.V.E.R.T. (www.institut-pivert.com)
   selected as an Investment for the Future ("Investissements d'Avenir").
   This work was supported, as part of the Investments for the Future, by
   the French Government under the reference ANR-001-01 (Agence Nationale
   de la Recherche, France). It was also financially supported by the
   Institut National de la Recherche Agronomique (INRA, France). C.F. was
   supported by a doctoral fellowship from the Region Aquitaine and the
   INRA (Departement de Nutrition Humaine; 22000763). The Western blot
   analysis was done in the Biochemistry and Biophysics Platform of the
   Bordeaux Neurocampus at the Bordeaux University funded by the LABEX
   BRAIN (France). The authors thank M. Cadet, C. Tridon, S. Delbary and B.
   Pere for taking care of the animals.
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NR 120
TC 6
Z9 9
U1 0
U2 15
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0889-1591
EI 1090-2139
J9 BRAIN BEHAV IMMUN
JI Brain Behav. Immun.
PD FEB
PY 2020
VL 84
BP 23
EP 35
DI 10.1016/j.bbi.2019.11.002
PG 13
WC Immunology; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Neurosciences & Neurology; Psychiatry
GA KN3QK
UT WOS:000514755200006
PM 31731013
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Cheng, YW
   Hung, CC
   Fang, WH
   Chen, WL
AF Cheng, Yung-Wen
   Hung, Chun-Chi
   Fang, Wen-Hui
   Chen, Wei-Liang
TI Association between Soluble α-Klotho Protein and Metabolic Syndrome in
   the Adult Population
SO BIOMOLECULES
LA English
DT Article
DE Klotho; FGF23; metabolic syndrome
ID FIBROBLAST; HOMEOSTASIS; EXPRESSION; MOUSE; MODEL; RISK
AB Klotho protein is an anti-aging protein and plays multiple roles in ion-regulation, anti-oxidative stress, and energy metabolism through various pathways. Metabolic syndrome is a combination of multiple conditions that compose of multiple risk factors of cardiovascular disease and type 2 diabetes. Gene regulation and protein expression are discovered associated with metabolic syndrome. We aimed to figure out the correlation between Klotho protein and metabolic syndrome in generally healthy adults. A cross-sectional study of 9976 respondents >= 18 years old from the US National Health and Nutrition Examination Survey (2007-2012) by utilizing their soluble Klotho protein concentrations. Multivariate linear regression models were used to analyze the effect of soluble Klotho protein on the prevalence of metabolic syndrome. Soluble Klotho protein concentration was inversely correlated with the presence of metabolic syndromes (p = 0.013) and numbers of components that met the definition of metabolic syndrome (p < 0.05). The concentration of Soluble Klotho protein was negatively associated with abdominal obesity and high triglyceride (TG) in the adjusted model (p < 0.05). Soluble Klotho protein is correlated with changing metabolic syndrome components in adults, especially central obesity and high TG levels. Despite conventional function as co-factor with fibroblast growth factor-23 (FGF23) that regulates phosphate and vitamin D homeostasis, FGF23-independent soluble Klotho protein may act on multiple signal pathways in different organs and tissue in roles of anti-aging and protection from metabolic syndrome.
C1 [Cheng, Yung-Wen; Fang, Wen-Hui; Chen, Wei-Liang] Triserv Gen Hosp, Sch Med, Div Family Med, Dept Family & Community Med,Natl Def Med Ctr, Taipei 114, Taiwan.
   [Hung, Chun-Chi] Triserv Gen Hosp, Sch Med, Dept Orthopaed Surg, Natl Def Med Ctr, Taipei 114, Taiwan.
   [Chen, Wei-Liang] Triserv Gen Hosp, Sch Med, Div Geriatr Med, Dept Family & Community Med,Natl Def Med Ctr, Taipei 114, Taiwan.
   [Chen, Wei-Liang] Natl Def Med Ctr, Dept Biochem, Taipei 114, Taiwan.
C3 Tri-Service General Hospital; National Defense Medical Center;
   Tri-Service General Hospital; National Defense Medical Center; National
   Defense Medical Center; Tri-Service General Hospital; National Defense
   Medical Center
RP Chen, WL (corresponding author), Triserv Gen Hosp, Sch Med, Div Family Med, Dept Family & Community Med,Natl Def Med Ctr, Taipei 114, Taiwan.; Chen, WL (corresponding author), Triserv Gen Hosp, Sch Med, Div Geriatr Med, Dept Family & Community Med,Natl Def Med Ctr, Taipei 114, Taiwan.; Chen, WL (corresponding author), Natl Def Med Ctr, Dept Biochem, Taipei 114, Taiwan.
EM cyw0451@gmail.com; raffi10110126@gmail.com; rumaf.fang@gmail.com;
   weiliang0508@gmail.com
OI Cheng, Yungwen/0000-0002-5002-4778
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NR 39
TC 25
Z9 26
U1 2
U2 5
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2218-273X
J9 BIOMOLECULES
JI Biomolecules
PD JAN
PY 2022
VL 12
IS 1
AR 70
DI 10.3390/biom12010070
PG 9
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA YQ8OJ
UT WOS:000749563800001
PM 35053218
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Alam, W
   Rocca, C
   Khan, H
   Hussain, Y
   Aschner, M
   De Bartolo, A
   Amodio, N
   Angelone, T
   Cheang, WS
AF Alam, Waqas
   Rocca, Carmine
   Khan, Haroon
   Hussain, Yaseen
   Aschner, Michael
   De Bartolo, Anna
   Amodio, Nicola
   Angelone, Tommaso
   Cheang, Wai San
TI Current Status and Future Perspectives on Therapeutic Potential of
   Apigenin: Focus on Metabolic-Syndrome-Dependent Organ Dysfunction
SO ANTIOXIDANTS
LA English
DT Review
DE apigenin; antioxidants; flavonoids; intracellular signalling; metabolic
   syndrome
ID 3RD NATIONAL-HEALTH; NF-KAPPA-B; ACTIVATED RECEPTOR-GAMMA; OXIDATIVE
   STRESS; PPAR-GAMMA; INSULIN-RESISTANCE; IN-VIVO; PHYTOCHEMICAL ANALYSIS;
   CARDIAC-HYPERTROPHY; FLAVONOID APIGENIN
AB Metabolic syndrome and its associated disorders such as obesity, insulin resistance, atherosclerosis and type 2 diabetes mellitus are globally prevalent. Different molecules showing therapeutic potential are currently available for the management of metabolic syndrome, although their efficacy has often been compromised by their poor bioavailability and side effects. Studies have been carried out on medicinal plant extracts for the treatment and prevention of metabolic syndrome. In this regard, isolated pure compounds have shown promising efficacy for the management of metabolic syndrome, both in preclinical and clinical settings. Apigenin, a natural bioactive flavonoid widely present in medicinal plants, functional foods, vegetables and fruits, exerts protective effects in models of neurological disorders and cardiovascular diseases and most of these effects are attributed to its antioxidant action. Various preclinical and clinical studies carried out so far show a protective effect of apigenin against metabolic syndrome. Herein, we provide a comprehensive review on both in vitro and in vivo evidence related to the promising antioxidant role of apigenin in cardioprotection, neuroprotection and renoprotection, and to its beneficial action in metabolic-syndrome-dependent organ dysfunction. We also provide evidence on the potential of apigenin in the prevention and/or treatment of metabolic syndrome, analysing the potential and limitation of its therapeutic use.
C1 [Alam, Waqas; Khan, Haroon] Abdul Wali Khan Univ Mardan, Dept Pharm, Mardan 23200, Pakistan.
   [Rocca, Carmine; De Bartolo, Anna; Angelone, Tommaso] Univ Calabria, Dept Biol Ecol & Earth Sci DiBEST, Lab Cellular & Mol Cardiovasc Physiol, I-87036 Arcavacata Di Rende, Italy.
   [Hussain, Yaseen] Soochow Univ, Coll Pharmaceut Sci, Suzhou 221400, Peoples R China.
   [Aschner, Michael] Albert Einstein Coll Med, Dept Mol Pharmacol, Forchheimer 209,1300 Morris Pk Ave, Bronx, NY 10461 USA.
   [Amodio, Nicola] Magna Graecia Univ Catanzaro, Dept Expt & Clin Med, I-88100 Catanzaro, Italy.
   [Angelone, Tommaso] Natl Inst Cardiovasc Res INRC, I-40126 Bologna, Italy.
   [Cheang, Wai San] Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Taipa 999078, Macao, Peoples R China.
C3 University of Calabria; Soochow University - China; Yeshiva University;
   Montefiore Medical Center; Albert Einstein College of Medicine; Magna
   Graecia University of Catanzaro; University of Macau
RP Khan, H (corresponding author), Abdul Wali Khan Univ Mardan, Dept Pharm, Mardan 23200, Pakistan.; Angelone, T (corresponding author), Univ Calabria, Dept Biol Ecol & Earth Sci DiBEST, Lab Cellular & Mol Cardiovasc Physiol, I-87036 Arcavacata Di Rende, Italy.; Amodio, N (corresponding author), Magna Graecia Univ Catanzaro, Dept Expt & Clin Med, I-88100 Catanzaro, Italy.; Angelone, T (corresponding author), Natl Inst Cardiovasc Res INRC, I-40126 Bologna, Italy.
EM waqasalam@awkum.edu.pk; carmine.rocca@unical.it; hkdr2006@gmail.com;
   20197250001@stu.suda.edu.cn; michael.aschner@einsteinmed.org;
   anna.de_bartolo@unical.it; haroonkhan@awkum.edu.pk;
   tommaso.angelone@unical.it; annacheang@um.edu.mo
RI Rocca, Carmine/AAN-1969-2020; Aschner, Michael/ACO-6461-2022; Angelone,
   Tommaso/AAM-1230-2020; Cheang, Wan San/W-9534-2019; De Bartolo,
   Anna/KHW-6017-2024; Khan, Prof. Dr. Haroon/AAY-1785-2020; Alam, Dr.
   Waqas/AAH-1001-2021
OI , Anna De Bartolo/0000-0003-3197-9461; Rocca,
   Carmine/0000-0002-1743-4724; Hussain, Yaseen/0000-0003-1054-6720;
   aschner, michael/0000-0002-2619-1656; Angelone,
   Tommaso/0000-0001-7797-7862; Khan, Prof. Dr. Haroon/0000-0002-1736-4404;
   Alam, Dr. Waqas/0000-0001-8329-9180; Cheang, Wai San/0000-0002-1152-7997
FU Italian Association for Cancer Research [683 del 21/05/2019]; Italian
   Ministry of Health [GR-2016-02361523];  [IG24449]
FX N.A. was supported by grants from Italian Association for Cancer
   Research (IG24449) and Italian Ministry of Health (GR-2016-02361523).
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NR 192
TC 29
Z9 30
U1 2
U2 19
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD OCT
PY 2021
VL 10
IS 10
AR 1643
DI 10.3390/antiox10101643
PG 28
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA WR9FB
UT WOS:000714797500001
PM 34679777
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Hammoudeh, S
   Al Lawati, H
   Ghuloum, S
   Iram, H
   Yehya, A
   Becetti, I
   Al-fakhri, N
   Ghabrash, H
   Shehata, M
   Ajmal, N
   Amro, I
   Safdar, H
   Eltorki, Y
   Al-Amin, H
AF Hammoudeh, Samer
   Al Lawati, Hawra
   Ghuloum, Suhaila
   Iram, Huma
   Yehya, Arij
   Becetti, Imen
   Al-fakhri, Nora
   Ghabrash, Hany
   Shehata, Mena
   Ajmal, Nighat
   Amro, Iman
   Safdar, Hira
   Eltorki, Yassin
   Al-Amin, Hassen
TI Risk Factors of Metabolic Syndrome Among Patients Receiving
   Antipsychotics: A Retrospective Study
SO COMMUNITY MENTAL HEALTH JOURNAL
LA English
DT Article
DE Metabolic syndrome; Antipsychotics; Arabs; Mental health; Retrospective;
   Qatar
ID 2ND-GENERATION ANTIPSYCHOTICS; CARDIOVASCULAR RISK; SCHIZOPHRENIA;
   PREVALENCE; COMPONENTS; INPATIENTS; POLYPHARMACY; PARAMETERS; PSYCHOSIS;
   OBESITY
AB This study aimed to assess the differential effects of first-generation (FGA) and second-generation antipsychotics (SGA) on the prevalence of risk factors for metabolic syndrome among mentally ill patients in Qatar. We also wanted to check if there is proper adherence with the guidelines for prescribing antipsychotics and the monitoring of metabolic effects in this population. We collected the available retrospective data (socio-demographic, psychiatric, anthropometric, and metabolic measures) from the records of 439 patients maintained on antipsychotics. The majority were males, married, employed, having a psychotic disorder, and receiving SGA. Patients on SGA showed more obesity, higher BP, and more elevated triglycerides compared to those on FGA. The prevalence of the abnormal metabolic measures was high in this sample, but those on SGA showed a significantly higher prevalence of abnormal body mass index and BP. Obesity and hypertension were common in patients maintained on antipsychotics, especially those on SGA. Polypharmacy was common, and many metabolic measures were not monitored properly in those maintained on antipsychotics. More prospective studies with guided monitoring of the patients' clinical status and metabolic changes are needed to serve better this population of patients.
C1 [Hammoudeh, Samer; Yehya, Arij; Amro, Iman] Weill Cornell Med Qatar, Res Dept, Doha, Qatar.
   [Al Lawati, Hawra; Becetti, Imen; Al-fakhri, Nora] Weill Cornell Med Qatar, Med Educ Dept, Doha, Qatar.
   [Ghuloum, Suhaila; Iram, Huma; Ghabrash, Hany; Shehata, Mena; Ajmal, Nighat; Safdar, Hira] Hamad Med Corp, Mental Hlth Hosp, Dept Psychiat, Doha, Qatar.
   [Eltorki, Yassin] Hamad Med Corp, Rumailah Hosp, Dept Pharm, Doha, Qatar.
   [Al-Amin, Hassen] Weill Cornell Med Qatar, Dept Psychiat, POB 24144, Doha, Qatar.
C3 Qatar Foundation (QF); Weill Cornell Medical College Qatar; Qatar
   Foundation (QF); Weill Cornell Medical College Qatar; Hamad Medical
   Corporation; Hamad Medical Corporation; Qatar Foundation (QF); Weill
   Cornell Medical College Qatar
RP Al-Amin, H (corresponding author), Weill Cornell Med Qatar, Dept Psychiat, POB 24144, Doha, Qatar.
EM haa2019@qatar-med.cornell.edu
RI Al-Amin, Hassen/ABC-3650-2020
OI Hammoudeh, Samer/0000-0003-0805-8111; Amro, Iman/0000-0001-7358-7963;
   AlFakhri, Nora/0000-0001-8206-3774; Yehya, Arij/0000-0001-6669-8470;
   Ghuloum, Suhaila/0000-0002-1384-4179; Al-Amin,
   Hassen/0000-0001-6358-1541
FU Medical Research Center at Hamad Medical Corporation, Doha, Qatar
   [IRGC-01-SI-009]; Qatar National Research Fund (QNRF) [UREP
   16-012-3-003]
FX This work was supported by a grant from the Medical Research Center at
   Hamad Medical Corporation, Doha, Qatar (IRGC-01-SI-009), and Qatar
   National Research Fund (QNRF) Grant: UREP 16-012-3-003. The funding
   agencies did not have any additional role in the study design, data
   collection and analysis, interpretation of data, decision to publish, or
   preparation of the manuscript.
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NR 55
TC 8
Z9 9
U1 0
U2 7
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0010-3853
EI 1573-2789
J9 COMMUNITY MENT HLT J
JI Community Ment. Health J.
PD MAY
PY 2020
VL 56
IS 4
BP 760
EP 770
DI 10.1007/s10597-019-00537-y
EA DEC 2019
PG 11
WC Health Policy & Services; Public, Environmental & Occupational Health;
   Psychiatry
WE Social Science Citation Index (SSCI)
SC Health Care Sciences & Services; Public, Environmental & Occupational
   Health; Psychiatry
GA KW4RD
UT WOS:000504620800001
PM 31884574
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Pervanidou, P
   Chrousos, GP
AF Pervanidou, Panagiota
   Chrousos, George P.
TI Early-Life Stress: From Neuroendocrine Mechanisms to Stress-Related
   Disorders
SO HORMONE RESEARCH IN PAEDIATRICS
LA English
DT Review
DE Children; Early-life stress; Cortisol; Catecholamines; Allostasis
ID EARLY-CHILDHOOD ADVERSITY; TRANSLATING DEVELOPMENTAL SCIENCE; HAIR
   CORTISOL CONCENTRATIONS; PITUITARY-ADRENAL AXIS; METABOLIC SYNDROME;
   ANXIETY DISORDERS; DAILY SALIVARY; CHILDREN; TRAUMA; ASSOCIATION
AB Stress exposure is highly prevalent in the general population; however, the experience of stress during vulnerable periods of development has substantial and permanent effects on brain structure and function and physical health in adulthood. Stress, the state of threatened homeostasis, is generally associated with a time-limited activation of the stress system, i.e., the hypothalamic-pituitary-adrenal axis and the arousal/sympathetic nervous system, tailored to the stressful stimulus also known as the stressor. On the other hand, chronic stress may be associated with lingering hyper- or hyposecretion of mediators of the stress system. This chronic condition is called dyshomeostasis, allostasis, or cacostasis and is associated with increased mental and physical morbidity in the long term. Stressful or traumatic experiences during fetal life, early childhood, and adolescence have been related to persistent neuroendocrine and epigenetic changes. Further, brain structures involved in the stress response, such as those of the stress system, the hippocampus, and the amygdala, may be programmed early on for a life of adversity. (C) 2018 S. Karger AG, Basel
C1 [Pervanidou, Panagiota; Chrousos, George P.] Natl & Kapodistrian Univ Athens, Sch Med, Dept Pediat 1, Div Dev & Behav Pediat, Athens, Greece.
C3 Athens Medical School; National & Kapodistrian University of Athens
RP Pervanidou, P (corresponding author), Natl & Kapodistrian Univ Athens, Div Dev & Behav Pediat, Dept Pediat 1, Sch Med,Aghia Sophia Childrens Hosp, GR-11527 Athens, Greece.
EM ppervanid@med.uoa.gr
RI Pervanidou, Panagiota/ABI-6356-2020; Chrousos, George/G-8702-2011
OI Pervanidou, Panagiota/0000-0002-6593-6489
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NR 58
TC 46
Z9 50
U1 2
U2 28
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1663-2818
EI 1663-2826
J9 HORM RES PAEDIAT
JI Horm. Res. Paediatr.
PY 2018
VL 89
IS 5
BP 372
EP 379
DI 10.1159/000488468
PG 8
WC Endocrinology & Metabolism; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Pediatrics
GA GN2WV
UT WOS:000438863900010
PM 29886495
DA 2025-06-11
ER

PT J
AU Stark, J
   Palombo, DJ
   Hayes, JP
   Hiersche, KJ
   Hasselbach, AN
   Hayes, SM
AF Stark, Jessica
   Palombo, Daniela J.
   Hayes, Jasmeet P.
   Hiersche, Kelly J.
   Hasselbach, Alexander N.
   Hayes, Scott M.
CA Alzheimer's Dis Neuroimaging Initi
TI Partial Least Squares Analysis of Alzheimer's Disease Biomarkers,
   Modifiable Health Variables, and Cognition in Older Adults with Mild
   Cognitive Impairment
SO JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY
LA English
DT Article
DE Healthy Aging; Neuropsychology; Neuroprotection; Neuroplasticity;
   Memory; Executive Function
ID METABOLIC SYNDROME; MEMORY; TAU; ASSOCIATION; TUTORIAL; RESERVE; VOLUME;
   RISK
AB Objectives: To identify novel associations between modifiable physical and health variables, Alzheimer's disease (AD) biomarkers, and cognitive function in a cohort of older adults with Mild Cognitive Impairment (MCI). Methods: Metrics of cardiometabolic risk, stress, inflammation, neurotrophic/growth factors, AD, and cognition were assessed in 154 MCI participants (Mean age = 74.1 years) from the Alzheimer's Disease Neuroimaging Initiative. Partial Least Squares analysis was employed to examine associations among these physiological variables and cognition. Results: Latent variable 1 revealed a unique combination of AD biomarkers, neurotrophic/growth factors, education, and stress that were significantly associated with specific domains of cognitive function, including episodic memory, executive function, processing speed, and language, representing 45.2% of the cross-block covariance in the data. Age, body mass index, and metrics tapping basic attention or premorbid IQ were not significant. Conclusions: Our data-driven analysis highlights the significant relationships between metrics associated with AD pathology, neuroprotection, and neuroplasticity, primarily with tasks tapping episodic memory, executive function, processing speed, and verbal fluency rather than more basic tasks that do not require mental manipulation (basic attention and vocabulary). These data also indicate that biological metrics are more strongly associated with episodic memory, executive function, and processing speed than chronological age in older adults with MCI.
C1 [Stark, Jessica; Hayes, Jasmeet P.; Hiersche, Kelly J.; Hasselbach, Alexander N.; Hayes, Scott M.] Ohio State Univ, Dept Psychol, Psychol Bldg,1835 Neil Ave, Columbus, OH 43210 USA.
   [Hayes, Jasmeet P.; Hayes, Scott M.] Univ British Columbia, Dept Psychol, Vancouver, BC, Canada.
   [Palombo, Daniela J.] Ohio State Univ, Chron Brain Injury Initiat, Columbus, OH 43210 USA.
C3 University System of Ohio; Ohio State University; University of British
   Columbia; University System of Ohio; Ohio State University
RP Hayes, SM (corresponding author), Ohio State Univ, Dept Psychol, Psychol Bldg,1835 Neil Ave, Columbus, OH 43210 USA.
EM hayes.1074@osu.edu
RI Hayes, Scott/AAL-8682-2020; Hayes, Jasmeet/AAN-4150-2020
OI Hayes, Scott/0000-0002-1185-5149; Hiersche, Kelly/0000-0003-2609-4298;
   Hayes, Jasmeet/0000-0002-5157-0666
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NR 23
TC 2
Z9 2
U1 3
U2 10
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 1355-6177
EI 1469-7661
J9 J INT NEUROPSYCH SOC
JI J. Int. Neuropsychol. Soc.
PD SEP
PY 2022
VL 28
IS 8
BP 781
EP 789
AR PII S1355617721001041
DI 10.1017/S1355617721001041
EA OCT 2021
PG 9
WC Clinical Neurology; Neurosciences; Psychiatry; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Psychiatry; Psychology
GA M1PD4
UT WOS:000768585800001
PM 34664547
OA Green Accepted, Green Submitted
DA 2025-06-11
ER

PT J
AU Schutte, CE
   Malan, L
   Scheepers, JD
   Oosthuizen, W
   Cockeran, M
   Malan, NT
AF Schutte, Christiaan E.
   Malan, Leone
   Scheepers, Jacobus D.
   Oosthuizen, Woudri
   Cockeran, Marike
   Malan, Nicolaas T.
TI Cortisol:brain-derived neurotrophic factor ratio associated with silent
   ischaemia in a black male cohort: the SABPA study
SO CARDIOVASCULAR JOURNAL OF AFRICA
LA English
DT Article
DE cortisol; brain-derived neurotrophic factor (BDNF); cardiometabolic
   disease
ID PSYCHOLOGICAL DISTRESS; VASCULAR-DISEASE; BLOOD-PRESSURE; STRESS;
   HYPERTENSION; RESPONSES; SYMPTOMS; BDNF; RISK; MEN
AB Aim: Emotional distress has been associated with cardiovascular disease (CVD) in Africans. Cortisol and brain-derived neurotrophic factor (BDNF), as markers of emotional distress, increase cardiometabolic risk. We therefore aimed to investigate associations between cardiometabolic risk markers and the cortisol-to-BDNF ratio (cortisol:BDNF).
   Methods: A cross-sectional study included a bi-ethnic gender cohort (n = 406) aged 44.7 +/- 9.52 years. Ambulatory blood pressure (ABPM), ECG, fasting serum cortisol and BDNF levels and cardiometabolic risk markers were obtained.
   Results: Africans had increased incidence of hyperglycaemia and 24-hour silent ischaemic events, and elevated 24-hour blood pressure (BP) and cortisol:BDNF ratios compared to Caucasians. Forward stepwise linear regression analysis underscored a similar trend with associations between hyperglycaemia, 24-hour BP [Adj R-2 0.21-0.29; beta 0.23 (0.1-0.4); p = 0.01], silent ischaemia [Adj R-2 0.22; beta 0.40 (0.2-0.6); p < 0.01] and cortisol:BDNF levels in Africans, mostly in the men.
   Conclusion: Attenuated cortisol levels in this group may be indicative of emotional distress and if chronic, drive the cortisol:BDNF ratio to desensitise BDNF. Desensitised cortisol:BDNF may sustain cardiometabolic risk and induce neurodegeneration in African men via silent ischaemia. Compensatory increases in blood pressure to increase perfusion and maintain homeostasis may increase coronary artery disease risk.
C1 [Schutte, Christiaan E.; Malan, Leone; Scheepers, Jacobus D.; Oosthuizen, Woudri; Malan, Nicolaas T.] North West Univ, HART, Potchefstroom Campus, Potchefstroom, South Africa.
   [Cockeran, Marike] North West Univ, Stat Consultat Serv, Potchefstroom Campus, Potchefstroom, South Africa.
C3 North West University - South Africa; North West University - South
   Africa
RP Malan, L (corresponding author), North West Univ, HART, Potchefstroom Campus, Potchefstroom, South Africa.
EM Leone.Malan@nwu.ac.za
RI Scheepers, Kobus/ITW-2350-2023; Malan, Leone/Q-8187-2019; Malan,
   Leone/D-7203-2014
OI Malan, Leone/0000-0003-3187-2410; Scheepers, Kobus/0000-0003-0372-4496;
   Cockeran, Marike/0000-0002-3990-8345
FU Metabolic Syndrome Institute, France; South African Medical Research
   Council; National Research Foundation (NRF), North-West University;
   North-West Department of Education; ROCHE Diagnostics, South Africa
FX The research was funded by the Metabolic Syndrome Institute, France;
   South African Medical Research Council; National Research Foundation
   (NRF), North-West University; North-West Department of Education; and
   ROCHE Diagnostics, South Africa.
CR Batty GD, 2014, ATHEROSCLEROSIS, V236, P385, DOI 10.1016/j.atherosclerosis.2014.06.025
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NR 25
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Z9 9
U1 0
U2 5
PU CLINICS CARDIVE PUBL PTY LTD
PI DURBANVILLE
PA PO BOX 1013, DURBANVILLE, 7551, SOUTH AFRICA
SN 1995-1892
EI 1680-0745
J9 CARDIOVASC J AFR
JI Cardiovasc. J. Afr.
PD NOV-DEC
PY 2016
VL 27
IS 6
BP 387
EP 391
DI 10.5830/CVJA-2016-065
PG 5
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA EG2RP
UT WOS:000390892000010
PM 27966001
OA Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Riley, E
   Mitko, A
   Stumps, A
   Robinson, M
   Milberg, W
   McGlinchey, R
   Esterman, M
   DeGutis, J
AF Riley, Elizabeth
   Mitko, Alex
   Stumps, Anna
   Robinson, Meghan
   Milberg, William
   McGlinchey, Regina
   Esterman, Michael
   DeGutis, Joseph
TI Clinically Significant Cognitive Dysfunction in OEF/OIF/OND Veterans:
   Prevalence and Clinical Associations
SO NEUROPSYCHOLOGY
LA English
DT Article
DE cognitive dysfunction; trauma exposure; OEF/OIF/OND Veterans; PTSD;
   alcohol consumption
ID POSTTRAUMATIC-STRESS-DISORDER; TRAUMATIC BRAIN-INJURY; METABOLIC
   SYNDROME; PSYCHOLOGICAL SYMPTOMS; PTSD; PERFORMANCE; MEMORY; DEPRESSION;
   RECOVERY; DISTRESS
AB Objective: Cognitive performance in trauma-exposed populations, such as combat Veterans, has been shown to be worse than in nonexposed peers. However, cognitive performance has typically been within the normal range (within 1 SD of normative mean), and the prevalence of clinically significant cognitive dysfunction (i.e., performance more than 1 SD below the mean on multiple measures in a domain) in younger adults with trauma exposure remains unknown. The objective of our study was to measure this. Method: We applied Diagnostic and Statistical Manual of Mental Disorders (5th ed.; DSM-5) cutoffs for clinically significant cognitive dysfunction (>1 SD below the mean in multiple measures within a domain) in the domains of memory, executive function, and attention to a sample of combat-exposed Operation Enduring Freedom/Operation Iraqi Freedom/Operation New Dawn (OEF/OIF/OND; N = 368, mean age = 31.7 years, 90% men) Veterans. We then compared psychiatric, physiological, and neural measures, as well as functional outcomes, between those with and without cognitive dysfunction. Results: Veterans with cognitive dysfunction (n = 129, 35.1%) had lower premorbid reading ability and more severe psychological distress, including increased anxiety, depression, posttraumatic stress disorder (PTSD), sleep difficulties, pain, and alcohol consumption. Those with cognitive dysfunction also had worse functional outcomes, with mild but significant disability. In contrast, we found associations between outcome and age, traumatic brain injury, physiological and neural measures to be weak or not significant. Conclusions: Together, this suggests that premorbid abilities and trauma-related psychological symptoms contribute significantly to cognitive dysfunction in OEF/OIF/OND Veterans, and that neurological insult and aging may play less of a role. Cognitive dysfunction may be at least partially ameliorated by treating trauma-related symptoms.
   General Scientific Summary
   In this study, we examined the psychological, physical and neurological health profiles of returning OEF/OIF/OND Veterans who had significant cognitive dysfunction. Though we did not find any evidence of physical or neural decline in those with cognitive dysfunction, we did find that those with cognitive dysfunction suffered from more intense psychological distress (posttraumatic stress disorder, depression, anxiety, sleep difficulties, pain) than those without. Our results suggest that cognitive dysfunction in younger returning Veterans might be ameliorated with appropriate treatment for psychological distress conditions.
C1 [Riley, Elizabeth] Cornell Univ, Dept Human Dev, Sch Human Ecol, 162 Human Ecol Bldg, Ithaca, NY 14850 USA.
   [Mitko, Alex; Stumps, Anna; Robinson, Meghan; Milberg, William; McGlinchey, Regina; Esterman, Michael; DeGutis, Joseph] VA Boston Healthcare Syst, Translat Res Ctr TBI & Stress Disorders TRACTS, VA RR&D TBI Ctr Excellence, Boston, MA USA.
   [Milberg, William; McGlinchey, Regina; DeGutis, Joseph] Harvard Med Sch, Dept Psychiat, Boston, MA 02115 USA.
   [Esterman, Michael] Boston Univ, Dept Psychiat, Sch Med, Boston, MA 02215 USA.
C3 Cornell University; Harvard University; Harvard University Medical
   Affiliates; US Department of Veterans Affairs; Veterans Health
   Administration (VHA); VA Boston Healthcare System; Harvard University;
   Harvard Medical School; Boston University
RP Riley, E (corresponding author), Cornell Univ, Dept Human Dev, Sch Human Ecol, 162 Human Ecol Bldg, Ithaca, NY 14850 USA.
EM er482@cornell.edu
OI Esterman, Michael/0000-0002-9000-3920; Robinson,
   Meghan/0000-0002-1110-1945
FU U.S. Department of Veteran Affairs through the VA Boston Translational
   Research Center for TBI and Stress Disorders (TRACTS), a VA
   Rehabilitation Research and Development Traumatic Brain Injury Center of
   Excellence [B9254-C]; Department of Veterans Affairs Clinical Sciences
   Research and Development [1IK2CX000706-01A2]
FX This work was supported by the U.S. Department of Veteran Affairs
   through the VA Boston Translational Research Center for TBI and Stress
   Disorders (TRACTS), a VA Rehabilitation Research and Development
   Traumatic Brain Injury Center of Excellence (B9254-C), and a Career
   Development award from the Department of Veterans Affairs Clinical
   Sciences Research and Development (1IK2CX000706-01A2) to M.S.E. We thank
   the Veterans for their patience and diligence in participating in this
   intensive study.
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NR 92
TC 41
Z9 47
U1 0
U2 7
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 0894-4105
EI 1931-1559
J9 NEUROPSYCHOLOGY
JI Neuropsychology
PD MAY
PY 2019
VL 33
IS 4
BP 534
EP 546
DI 10.1037/neu0000529
PG 13
WC Psychology, Clinical; Neurosciences; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Neurosciences & Neurology
GA HV6RI
UT WOS:000466110100009
PM 30945914
DA 2025-06-11
ER

PT J
AU Arshad, N'
   Lin, TS
   Yahaya, MF
AF Arshad, Nurul 'Ain
   Lin, Teoh Seong
   Yahaya, Mohamad Fairuz
TI Stingless Bee Honey Reduces Anxiety and Improves Memory of the Metabolic
   Disease-induced Rats
SO CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
LA English
DT Article
DE Kelulut honey; metabolic syndrome; brain; behavior; phenolic content;
   neurological function
ID ANTIOXIDANT CAPACITY; PHENOLIC-COMPOUNDS; LIPID-METABOLISM; QUERCETIN;
   BLOOD; ACID; PERFORMANCE; SUPPLEMENT; PROPOLIS; EXTRACT
AB Background: Scientific studies support the evidence of the involvement of Metabolic Syndrome (MetS) in the progression of neurodegenerative diseases through oxidative stress. Consumption of antioxidant compounds was found to be beneficial for brain-health as it reduced the brain oxidative stress level and improved cognitive performance in animals. Stingless bee honey or locally known as Kelulut Honey (KU) has high phenolic content and is widely used as a food supplement.
   Objectives: In this study, we aimed to investigate the effects of KH on the brain of MetS-induced rats.
   Methods: Forty male Wistar rats were divided into 5 groups; 8 weeks (C8) and 16 weeks control groups (C16), groups that received High-Carbohydrate High Fructose (HCHF) diet for 8 weeks (MS8) and 16 weeks (MS16), and a group that received HCHF for 16 weeks with KH supplemented for the last 35 days (KH).
   Results: Serum fasting blood glucose decreased in the KH group compared to the MS16 group. I IDL levels were significantly decreased in MetS groups compared to control groups. Open field experiments showed that KH group exhibits less anxious behavior compared to the MetS group. Probe trial of Morris water maze demonstrated significant memory retention of KH group compared to the MS16 group. Nissl staining showed a significant decrease in the pyramidal hippocampal cells in the MS16 compared to the KH group.
   Conclusion: KH has the ability to normalise blood glucose and reduce serum triglyceride and LDL levels in MetS rats, while behavior studies complement its effect on anxiety and memory. This shows a promising role of KH in attenuating neurodegenerative diseases through the antioxidant activity of its polyphenolic content.
C1 [Arshad, Nurul 'Ain; Lin, Teoh Seong; Yahaya, Mohamad Fairuz] Univ Kebangsaan Malaysia, Fac Med, Dept Anat, Med Ctr, Jalan Yaacob Latif, Kuala Lumpur 56000, Malaysia.
   [Arshad, Nurul 'Ain] Nilai Univ, Fac Engn Sci & Technol, Sch Nursing, Nilai 71800, Negeri Sembilan, Malaysia.
C3 Universiti Kebangsaan Malaysia
RP Yahaya, MF (corresponding author), Univ Kebangsaan Malaysia, Fac Med, Dept Anat, Med Ctr, Jalan Yaacob Latif, Kuala Lumpur 56000, Malaysia.
EM mfairuzy@ukm.edu.my
RI Teoh, Seong/P-3950-2017; Yahaya, Mohamad/K-7614-2019
OI Arshad, Nurul 'Ain/0000-0002-9761-7941
FU Universiti Kebangsaan Malaysia Research Grant [FF-2017-449,
   GGP-2017-092]
FX This work was supported by Universiti Kebangsaan Malaysia Research Grant
   (FF-2017-449 and GGP-2017-092).
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NR 66
TC 21
Z9 22
U1 1
U2 16
PU BENTHAM SCIENCE PUBL
PI BUSUM
PA PO BOX 294, BUSUM, 1400 AG, NETHERLANDS
SN 1871-5273
EI 1996-3181
J9 CNS NEUROL DISORD-DR
JI CNS Neurol. Disord.-Drug Targets
PY 2020
VL 19
IS 2
BP 115
EP 126
DI 10.2174/1871527319666200117105133
PG 12
WC Neurosciences; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pharmacology & Pharmacy
GA MB5QG
UT WOS:000542656800004
PM 31957619
DA 2025-06-11
ER

PT J
AU Paschos, P
   Paletas, K
AF Paschos, P.
   Paletas, K.
TI Non alcoholic fatty liver disease and metabolic syndrome
SO HIPPOKRATIA
LA English
DT Review
DE non alcoholic fatty liver disease; non alcoholic steatohepatitis;
   metabolic syndrome
ID NONALCOHOLIC STEATOHEPATITIS; INSULIN-RESISTANCE; HEPATIC STEATOSIS;
   RISK-FACTORS; AMINOTRANSFERASE LEVELS; NONINVASIVE DIAGNOSIS;
   PROVISIONAL REPORT; NATURAL-HISTORY; FIBROSIS; PREVALENCE
AB Non-alcoholic fatty liver disease (NAFLD) is a clinicopathologic entity increasingly recognized as a major health burden in developed countries. It includes a spectrum of liver damage ranging from simple steatosis to nonalcoholic steatohepatitis (NASH), advanced fibrosis, and rarely, progression to cirrhosis. Recent studies emphasize the role of insulin resistance, oxidative stress and subsequent lipid peroxidation, proinflammatory cytokines, adipokines and mitochondrial dysfunction in the development and progression of NAFLD. Furthermore, accumulating evidence supports all association between NAFLD and metabolic syndrome. Although the data are mainly epidemiological, the pathogenesis of NAFLD and metabolic syndrome seems to have common pathophysiological mechanisms, with focus on insulin resistance as a key factor. This review summarizes the Current knowledge oil the epidemiology, pathophysiology and diagnosis of both NAFLD and metabolic syndrome and the findings that strongly Support the association of nonalcoholic fatty liver disease as a possible component in the cluster of metabolic syndrome. Hippokratia 2009; 13 (1): 9-19
C1 [Paschos, P.; Paletas, K.] Aristotle Univ Thessaloniki, Hippokratio Gen Hosp, Dept Internal Med 2, Metab Dis Unit, Thessaloniki 54642, Greece.
C3 Aristotle University of Thessaloniki
RP Paschos, P (corresponding author), Aristotle Univ Thessaloniki, Hippokratio Gen Hosp, Dept Internal Med 2, Metab Dis Unit, 49 Konstantinoupoleos St, Thessaloniki 54642, Greece.
EM paletas@med.auth.gr
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NR 137
TC 458
Z9 521
U1 0
U2 16
PU LITHOGRAPHIA
PI THESSALONIKI
PA ANTONIADIS I-PSARRAS TH G P, NEA REDESTOS, THESSALONIKI, 00000, GREECE
SN 1108-4189
J9 HIPPOKRATIA
JI Hippokratia
PD JAN-MAR
PY 2009
VL 13
IS 1
BP 9
EP 19
PG 11
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 396IH
UT WOS:000262584900002
PM 19240815
DA 2025-06-11
ER

PT J
AU Fadini, GP
   Ceolotto, G
   Pagnin, E
   de Kreutzenberg, S
   Avogaro, A
AF Fadini, Gian Paolo
   Ceolotto, Giulio
   Pagnin, Elisa
   de Kreutzenberg, Saula
   Avogaro, Angelo
TI At the crossroads of longevity and metabolism: the metabolic syndrome
   and lifespan determinant pathways
SO AGING CELL
LA English
DT Review
DE Integrative biology; metabolic syndrome; morbidity; mortality; oxidative
   stress
ID ACTIVATED PROTEIN-KINASE; FOXO TRANSCRIPTION FACTORS; TYPE-2
   DIABETES-MELLITUS; HIGH-FAT-DIET; OXIDATIVE STRESS; CALORIE RESTRICTION;
   SIRT1 DEACETYLASE; ALL-CAUSE; SACCHAROMYCES-CEREVISIAE; CELL-SURVIVAL
AB P>The metabolic syndrome is becoming increasingly prevalent in the general population and carries significant incremental morbidity and mortality. It is associated with multi-organ involvement and increased all-cause mortality, resembling a precocious aging process. The mechanisms that account for this phenomenon are incompletely known, but it is becoming clear that longevity genes might be involved. Experiments with overactivation or disruption of key lifespan determinant pathways, such as silent information regulator (SIR)T1, p66Shc, and mammalian target of rapamycin (TOR), lead to development of features of the metabolic syndrome in mice. These genes integrate longevity pathways and metabolic signals in a complex interplay in which lifespan appears to be strictly dependent on substrate and energy bioavailability. Herein, we describe the roles and possible interconnections of selected lifespan determinant molecular networks in the development of the metabolic syndrome and its complications, describing initial available data in humans. Additional pathways are involved in linking nutrient availability and longevity, certainly including insulin and Insulin-like Growth Factor-1 (IGF-1) signaling, as well as FOXO transcription factors. The model described in this viewpoint article is therefore likely to be an oversimplification. Nevertheless, it represents one starting platform for understanding cell biology of lifespan in relation to the metabolic syndrome.
C1 [Fadini, Gian Paolo] Univ Padua, Sch Med, Dept Clin & Expt Med, Div Metab, Padua, Italy.
   [Fadini, Gian Paolo; Avogaro, Angelo] Venetian Inst Mol Med, Padua, Italy.
C3 University of Padua; Veneto Institute Molecular Medicine
RP Fadini, GP (corresponding author), Univ Padua, Sch Med, Dept Clin & Expt Med, Div Metab, Padua, Italy.
EM gianpaolofadini@hotmail.com
RI de Kreutzenberg, S./AAA-4277-2022; Fadini, Gian/M-4575-2019; Avogaro,
   Angelo/S-3808-2016
OI FADINI, GIAN PAOLO/0000-0002-6510-2097; Ceolotto,
   Giulio/0000-0002-4687-8033; AVOGARO, ANGELO/0000-0002-1177-0516
FU European Foundation for the Study of Diabetes (EFSD)
FX Supported by a European Foundation for the Study of Diabetes (EFSD)
   Grant to AA. GPF is supported by a EFSD fellowship.
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NR 86
TC 74
Z9 84
U1 0
U2 13
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1474-9718
J9 AGING CELL
JI Aging Cell
PD FEB
PY 2011
VL 10
IS 1
BP 10
EP 17
DI 10.1111/j.1474-9726.2010.00642.x
PG 8
WC Cell Biology; Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Geriatrics & Gerontology
GA 705PH
UT WOS:000286147900004
PM 21040402
OA Green Submitted, hybrid
DA 2025-06-11
ER

PT J
AU Joyce, T
   Chirino, YI
   Natalia, MT
   Jose, PC
AF Joyce, Trujillo
   Chirino, Yolanda Irasema
   Natalia, Martinez-Taguena
   Jose, Pedraza-Chaverri
TI Renal damage in the metabolic syndrome (MetSx): Disorders implicated
SO EUROPEAN JOURNAL OF PHARMACOLOGY
LA English
DT Review
DE Metabolic syndrome; Chronic kidney disease; Insulin resistance;
   Dysbiosis; Sociological aspects
ID CHRONIC KIDNEY-DISEASE; INDUCED OXIDATIVE STRESS; MODIFIABLE LIFE-STYLE;
   INSULIN-RESISTANCE; ANGIOTENSIN-II; GUT MICROBIOTA; ENDOTHELIAL
   DYSFUNCTION; RISK-FACTOR; TNF-ALPHA; CARDIOVASCULAR-DISEASE
AB The prevalence of metabolic syndrome is increasing worldwide and has become a risk factor for the development of chronic kidney disease. The complex linkage between metabolic syndrome and chronic kidney disease is under research and the factors involved beyond the biological pathogenesis include demographic, sociological and psychological factors that are related to the metabolic syndrome prevalence. The social context of disease causation is as relevant to today's clinical scientist and practitioner as biomarker-directed risk stratification and therapy. The aim of this review is to compare the criteria for diagnosis among different international health organizations, identifying all factors that contribute to the development of this association between metabolic syndrome and chronic kidney disease, and categorizing them by those that could be useful for preventive strategies. In addition, patients with metabolic syndrome have microvascular disease characterized by micro-albuminuria, decreased glomerular filtration rate, tubular atrophy, interstitial fibrosis, and glomerulosclerosis. These effects may be due to insulin resistance, hypertension, dyslipidemias, activation of inflammatory processes, fibrotic, dysbiosis and generation of oxidative stress; which cause an imbalance in the main vasoactive factors and thus endothelial dysfunction, deteriorating the renal function. Furthermore, since unhealthy eating habits and a sedentary lifestyle are among the strongest risk factors related to these diseases, lifestyle interventions programs have been recommended for facilitating positive changes in behavior at the individual level. However, further research is needed to promote multiple social, economic and political transformations, shifting the intervention emphasis from individual education, counseling, regimens and medications to community, national and global institutions.
C1 [Joyce, Trujillo; Natalia, Martinez-Taguena] Consejo Nacl Ciencia & Technol, IPICYT, CIIDZA, CONACYT, San Luis Potosi 78216, Mexico.
   [Chirino, Yolanda Irasema] Univ Nacl Autonoma Mexico, Fac Estudios Super Iztacala, Unidad Biomed, Lab Carcinogenesis & Toxicol, Mexico City 54059, Estado De Mexic, Mexico.
   [Jose, Pedraza-Chaverri] Univ Nacl Autonoma Mexico, Fac Quim, Dept Biol, Ciudad Univ, Ciudad De Mexico 04510, Mexico.
C3 Instituto Potosino Investigacion Cientifica y Tecnologica; Consejo
   Nacional de Ciencia y Tecnologia (CONACyT); Universidad Nacional
   Autonoma de Mexico; Universidad Nacional Autonoma de Mexico
RP Joyce, T (corresponding author), Consejo Nacl Ciencia & Technol, CIIDZA, AC IPICYT, Inst Potosino Invest Cient & Tecnol, Delta Bldg,Camino Presa San Jose 2055, San Luis Potosi 78216, Mexico.; Jose, PC (corresponding author), Natl Autonomous Univ Mexico UNAM, Dept Biol, Fac Chem, Lab 209,Bldg F, Univ City 04510, DF, Mexico.
EM daniela.trujillo@ipicyt.edu.mx; pedraza@unam.mx
RI Trujillo Silva, Joyce/N-7869-2017
OI Trujillo Silva, Joyce/0000-0002-6419-2932; Martinez-Taguena,
   Natalia/0000-0002-7976-4198
FU program "Catedras CONACYT" [615]
FX We thank Graham Matthew Tippett for copyediting assistance of the
   manuscript. JT and NMT are supported as researcher fellows by the
   program "Catedras CONACYT" (project number 615).
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NR 188
TC 17
Z9 17
U1 0
U2 24
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0014-2999
EI 1879-0712
J9 EUR J PHARMACOL
JI Eur. J. Pharmacol.
PD JAN 5
PY 2018
VL 818
BP 554
EP 568
DI 10.1016/j.ejphar.2017.11.032
PG 15
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Pharmacology & Pharmacy
GA FQ7DL
UT WOS:000418522900065
PM 29162432
DA 2025-06-11
ER

PT J
AU Al-Sawalha, NA
   Almahmmod, Y
   Awawdeh, MS
   Alzoubi, KH
   Khabour, OF
AF Al-Sawalha, Nour A.
   Almahmmod, Yehya
   Awawdeh, Mofleh S.
   Alzoubi, Karem H.
   Khabour, Omar F.
TI Effect of waterpipe tobacco smoke exposure on the development of
   metabolic syndrome in adult male rats
SO PLOS ONE
LA English
DT Article
ID INSULIN-RESISTANCE; OXIDATIVE STRESS; ADIPONECTIN; LEPTIN; GHRELIN
AB The prevalence of metabolic syndrome is increased worldwide. Tobacco smoking increases the risk of developing metabolic syndrome. Waterpipe tobacco smoking has become a global trend of tobacco consumption and is as common as cigarette smoking. In this study, the effect of waterpipe tobacco smoke (WTS) on the development of metabolic syndrome in rats was evaluated. Adult Wistar rats were exposed for 19 weeks to either fresh air (control) or WTS for 1 hour daily/ 5 days per week (WTS). Central obesity, systolic blood pressure, lipid profile, glucose hemostasis and levels of leptin and adiponectin were evaluated. The WTS exposure increased body weight, abdominal circumference, systolic blood pressure and fasting glucose compared to control animals (P<0.05), consistent with inducing metabolic syndrome. The retroperitoneal fat, lipid profile and levels of insulin, leptin and adiponectin were not affected by WTS exposure (P>0.05). In conclusion, exposure to WTS has detrimental health effects leading to the development of metabolic syndrome in experimental animals.
C1 [Al-Sawalha, Nour A.; Almahmmod, Yehya; Alzoubi, Karem H.] Jordan Univ Sci & Technol, Fac Pharm, Dept Clin Pharm, Irbid, Jordan.
   [Awawdeh, Mofleh S.] Jordan Univ Sci & Technol, Fac Vet Med, Dept Vet Pathol & Publ Hlth, Irbid, Jordan.
   [Khabour, Omar F.] Jordan Univ Sci & Technol, Fac Appl Med Sci, Dept Med Lab Sci, Irbid, Jordan.
C3 Jordan University of Science & Technology; Jordan University of Science
   & Technology; Jordan University of Science & Technology
RP Al-Sawalha, NA (corresponding author), Jordan Univ Sci & Technol, Fac Pharm, Dept Clin Pharm, Irbid, Jordan.
EM nasawalha@just.edu.jo
RI Khabour, Omar/AGE-1685-2022; Alzoubi, Karem/E-6285-2014
OI Al-Sawalha, Nour/0000-0002-7401-8065; Khabour, Omar/0000-0002-3006-3104
FU Jordan University of Science and Technology, Irbid, Jordan [118/2017]
FX This study was supported by the deanship of research (grant number
   118/2017, NAS, MA, KHA) at Jordan University of Science and Technology,
   Irbid, Jordan,
   http://www.just.edu.jo/Deanships/DeanshipofResearch/Pages/Default.aspx.T
   he funder had no role in study design, data collection and analysis,
   decision to publish, or preparation of the manuscript.
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NR 40
TC 12
Z9 13
U1 2
U2 7
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JUN 19
PY 2020
VL 15
IS 6
AR e0234516
DI 10.1371/journal.pone.0234516
PG 9
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA MC4LX
UT WOS:000543261600009
PM 32559253
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Wolk, R
   Somers, VK
AF Wolk, Robert
   Somers, Virend K.
TI Sleep and the metabolic syndrome
SO EXPERIMENTAL PHYSIOLOGY
LA English
DT Review
ID POSITIVE AIRWAY PRESSURE; NECROSIS-FACTOR-ALPHA; INDUCED
   INSULIN-RESISTANCE; C-REACTIVE PROTEIN; MONOCYTE CHEMOATTRACTANT
   PROTEIN-1; CARDIOVASCULAR RISK-FACTORS; BODY-FAT DISTRIBUTION; APNEA
   SYNDROME; BLOOD-PRESSURE; OXIDATIVE STRESS
AB The metabolic syndrome represents a clustering of several interrelated risk factors of metabolic origin that are thought to increase cardiovascular risk. It is still uncertain whether this clustering results from multiple underlying risk factors or whether it has a single cause. One metabolic abnormality that may underlie several clinical characteristics of the metabolic syndrome is insulin resistance. This review discusses the evidence that sleep disturbances (obstructive sleep apnoea, sleep deprivation and shift work) may independently lead to the development of both insulin resistance and individual clinical components of the metabolic syndrome. The converse may also be true, in that metabolic abnormalities associated with the metabolic syndrome and insulin resistance may potentially exacerbate sleep disorders. The notion that sleep disturbances exert detrimental metabolic effects may help explain the increasing prevalence of the metabolic syndrome and insulin resistance in the general population and may have important implications for population-based approaches to combat the increasing epidemic of metabolic and cardiovascular disease.
C1 Pfizer Global Res & Dev, Cardiovasc Metab Dis, Groton, CT 06340 USA.
   Mayo Clin, Coll Med, Dept Med, Div Cardiovasc Dis, Rochester, MN USA.
C3 Pfizer; Pfizer USA; Mayo Clinic
RP Wolk, R (corresponding author), Pfizer Global Res & Dev, Cardiovasc Metab Dis, Point Rd,MS 8260-2506, Groton, CT 06340 USA.
EM robert.wolk@pfizer.com
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NR 127
TC 141
Z9 157
U1 1
U2 11
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0958-0670
EI 1469-445X
J9 EXP PHYSIOL
JI Exp. Physiol.
PD JAN 1
PY 2007
VL 92
IS 1
BP 67
EP 78
DI 10.1113/expphysiol.2006.033787
PG 12
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA 125VX
UT WOS:000243472700009
PM 17085678
OA Bronze
DA 2025-06-11
ER

PT J
AU Kojima, M
   Kojima, T
   Ishiguro, N
   Oguchi, T
   Oba, M
   Tsuchiya, H
   Sugiura, F
   Furukawa, TA
   Suzuki, S
   Tokudome, S
AF Kojima, Masayo
   Kojima, Toshihisa
   Ishiguro, Naoki
   Oguchi, Takeshi
   Oba, Michinari
   Tsuchiya, Hiroki
   Sugiura, Fumiaki
   Furukawa, Toshiaki A.
   Suzuki, Sadao
   Tokudome, Shinkan
TI Psychosocial factors, disease status, and quality of life in patients
   with rheumatoid arthritis
SO JOURNAL OF PSYCHOSOMATIC RESEARCH
LA English
DT Article
DE Disease status; Factor analysis; Psychosocial factors; QOL; Rheumatoid
   arthritis
ID METABOLIC SYNDROME; SOCIAL SUPPORT; HEALTH SURVEY; DEPRESSION; SF-36;
   SENSITIVITY; VALIDATION
AB Objective: To explore the interrelationships between the psychosocial and illness factors that determine the disease status of patients with rheumatoid arthritis (RA) and to identify how each factor is associated with quality of life (QOL). Methods: The Study group comprised 120 RA outpatients who completed a series of health examinations and questionnaires. Disease severity, functional disability, counts of swollen and/or tender joints, duration of RA, frequency of arthritis surgery, and C-reactive protein level were assessed by rheumatologists. Self-report inventories completed by the patients were used to assess perceived degree of pain, fatigue (visual analogue scales), depression (Beck Depression Inventory-II), anxiety (Hospital Anxiety and Depression Scale), and social support (Social Support Questionnaire). Mental and physical components of health-related QOL were evaluated using the Short-Form 36 Health Survey. Results: After z-transformation of the data, a principal axis factor analysis was conducted. A four-factor structure was identified in which the components reflected psychosocial factors, disease activity, current symptoms, and physical functional status, respectively. There was no significant association between psychosocial factors and disease activity, while the other components were moderately correlated with each other. Multiple regression analysis revealed that physical QOL was determined by current symptoms and physical functions. Mental QOL was determined by psychosocial factors, current symptoms, and physical functions. Conclusion: Disease activity was independent from psychosocial factors and failed to reflect the perceived physical and mental QOL of RA patients. Clinicians should therefore evaluate psychosocial factors, as well as subjective disease status, to improve the QOL of patients with RA. (C) 2009 Elsevier Inc. All rights reserved.
C1 [Kojima, Masayo; Suzuki, Sadao; Tokudome, Shinkan] Nagoya City Univ, Grad Sch Med Sci, Dept Publ Hlth, Mizuho Ku, Nagoya, Aichi 4678601, Japan.
   [Kojima, Toshihisa; Ishiguro, Naoki; Oguchi, Takeshi; Oba, Michinari; Tsuchiya, Hiroki; Sugiura, Fumiaki] Nagoya Univ, Sch Med, Dept Orthoped Surg, Showa Ku, Nagoya, Aichi 4668550, Japan.
   [Furukawa, Toshiaki A.] Nagoya City Univ, Grad Sch Med Sci, Dept Psychiat & Cognit Behav Med, Mizuho Ku, Nagoya, Aichi 4678601, Japan.
C3 Nagoya City University; Nagoya University; Nagoya City University
RP Kojima, M (corresponding author), Nagoya City Univ, Grad Sch Med Sci, Dept Publ Hlth, Mizuho Ku, 1 Kawasumi,Mizuho Cho, Nagoya, Aichi 4678601, Japan.
EM masayok@med.nagoya-cu.ac.jp
RI Kojima, Toshihisa/I-7366-2014; Ishiguro, Naoki/I-1563-2012; Furukawa,
   Toshi/B-9259-2011
OI TOKUDOME, SHINKAN/0000-0001-7311-2458; Kojima,
   Masayo/0000-0002-8946-1131; Furukawa, Toshi/0000-0003-2159-3776
FU Grants-in-Aid for Scientific Research [21590708] Funding Source: KAKEN
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NR 28
TC 71
Z9 81
U1 0
U2 13
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-3999
EI 1879-1360
J9 J PSYCHOSOM RES
JI J. Psychosomat. Res.
PD NOV
PY 2009
VL 67
IS 5
BP 425
EP 431
DI 10.1016/j.jpsychores.2009.01.001
PG 7
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 513TZ
UT WOS:000271348000008
PM 19837205
DA 2025-06-11
ER

PT J
AU da Fonseca, LJS
   Nunes-Souza, V
   Guedes, GD
   Schettino-Silva, G
   Mota-Gomes, MA
   Rabelo, LA
AF Sa da Fonseca, Lucas Jose
   Nunes-Souza, Valeria
   Guedes, Glaucevane da Silva
   Schettino-Silva, Glauber
   Mota-Gomes, Marco Antonio
   Rabelo, Luiza Antas
TI Oxidative Status Imbalance in Patients with Metabolic Syndrome: Role of
   the Myeloperoxidase/Hydrogen Peroxide Axis
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Article
ID NITRIC-OXIDE SYNTHASE; ENDOTHELIAL DYSFUNCTION; ARTERIAL STIFFNESS;
   PULSE-WAVE; SYNDROME COMPONENTS; INSULIN-RESISTANCE; CATALYTIC-ACTIVITY;
   ARGINASE ACTIVITY; STRESS; DISEASE
AB The present study evaluated the cardiometabolic and redox balance profiles in patients with Metabolic Syndrome compared to apparently healthy individuals, and the participation of the myeloperoxidase/hydrogen peroxide axis in systemic lipid peroxidation. Twenty-four patients with Metabolic Syndrome and eighteen controls underwent a full clinical assessment. Venous blood samples were collected for general biochemical dosages, as well as for the oxidative stress analyses (superoxide dismutase, catalase, and arginase activities; and lipid peroxidation, myeloperoxidase activity, nitrite, and hydrogen peroxide concentrations in plasma). Arterial stiffness was assessed by radial artery applanation tonometry. Plasma lipid peroxidation, erythrocyte superoxide dismutase activity, myeloperoxidase activity, and hydrogen peroxide concentrations were shown to be increased in Metabolic Syndrome patients, without significant differences for the other enzymes, plasma nitrite concentrations, and arterial stiffness. Linear regression analysis revealed a positive and significant correlation between lipid peroxidation and myeloperoxidase and also between this enzyme and hydrogen peroxide. In contrast, such correlation was not observed between lipid peroxidation and hydrogen peroxide. In summary, Metabolic Syndrome patients exhibited evident systemic redox imbalance compared to controls, with the possible participation of the myeloperoxidase/hydrogen peroxide axis as a contributor in lipid peroxidation.
C1 [Sa da Fonseca, Lucas Jose; Nunes-Souza, Valeria; Guedes, Glaucevane da Silva; Schettino-Silva, Glauber; Rabelo, Luiza Antas] Univ Fed Alagoas, UFAL, ICBS, Lab Reatividade Cardiovasc,Setor Fisiol & Farmaco, BR-57072900 Maceio, AL, Brazil.
   [Nunes-Souza, Valeria; Guedes, Glaucevane da Silva; Rabelo, Luiza Antas] Inst Nacl Ciencia & Tecnol NanoBiofarmaceut N BIO, Belo Horizonte, MG, Brazil.
   [Nunes-Souza, Valeria; Rabelo, Luiza Antas] Max Delbruck Ctr Mol Med, D-13125 Berlin, Germany.
   [Guedes, Glaucevane da Silva] Univ Fed Alagoas, UFAL, Fac Nutr FANUT, BR-57072900 Maceio, AL, Brazil.
   [Mota-Gomes, Marco Antonio] Hosp Coracao Alagoas HCOR AL, Ctr Pesquisas Clin, BR-57052580 Maceio, AL, Brazil.
C3 Universidade Federal de Alagoas; Helmholtz Association; Max Delbruck
   Center for Molecular Medicine; Universidade Federal de Alagoas
RP Rabelo, LA (corresponding author), Univ Fed Alagoas, UFAL, ICBS, Lab Reatividade Cardiovasc,Setor Fisiol & Farmaco, Ave Lourival Melo Mota S-N, BR-57072900 Maceio, AL, Brazil.
EM luizaa.rabelo@gmail.com
RI Rabêlo, Luiza/S-4050-2019
FU Coordenacao de Aperfeic, oamento de Pessoal de Nivel Superior (CAPES)
   [PROCAD-NF 2450/2008]; Conselho Nacional de Desenvolvimento Cientifico e
   Tecnologico (CNPq) [483049/2009-3]; CAPES; Deutscher Akademischer
   Austauschdienst (DAAD)/(CNPq)/Brazil [246794/2012-7]
FX The authors wish to thank Coordenacao de Aperfeic, oamento de Pessoal de
   Nivel Superior (CAPES; PROCAD-NF 2450/2008) and Conselho Nacional de
   Desenvolvimento Cientifico e Tecnologico (CNPq; 483049/2009-3) for the
   financial support and Professor Dr. Michael Bader and Dr. Natalia
   Alenina (Max Delbruck Center for Molecular Medicine, Berlin, Germany)
   for the donation of some reagents used during the assessment of the
   oxidative status. Lucas Jose Sa da Fonseca received a Masters
   Scholarship from CAPES and Valeria Nunes-Souza was supported by a
   Fellowship from Deutscher Akademischer Austauschdienst
   (DAAD)/(CNPq)/Brazil (Process 246794/2012-7).
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NR 55
TC 13
Z9 14
U1 0
U2 5
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PY 2014
VL 2014
AR 898501
DI 10.1155/2014/898501
PG 14
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA AT6BF
UT WOS:000345023000001
PM 25386227
OA Green Published, hybrid, Green Submitted
DA 2025-06-11
ER

PT J
AU Ramadan, G
   El-Beih, NM
   Abd El-Kareem, HF
AF Ramadan, Gamal
   El-Beih, Nadia M.
   Abd El-Kareem, Hanaa F.
TI Anti-metabolic syndrome and immunostimulant activities of Egyptian
   fenugreek seeds in diabetic/obese and immunosuppressive rat models
SO BRITISH JOURNAL OF NUTRITION
LA English
DT Article
DE Albino rats; Diabetes and obesity; Fenugreek seeds; Immunosuppression;
   Metabolic syndrome
ID DENSITY LIPOPROTEIN CHOLESTEROL; OXIDATIVE STRESS; AQUEOUS EXTRACT;
   CYCLOPHOSPHAMIDE; MICE; L.; HYPERLIPIDEMIA; POLYPHENOLS; ALLOXAN;
   DISEASE
AB Preliminary trials have suggested possible hypoglycaemic, hypolipidaemic and immunomodulatory properties of the fenugreek plant. Here, we evaluated and compared the efficacy of Egyptian fenugreek seed powder (FSP, 0.5 and 1.0 g/kg body weight) in alleviating the experimentally induced metabolic syndrome (in type 1 diabetic and obese rat models) and experimentally induced immunosuppression and delay in burn-healing (in cyclophosphamide (CP)-treated rats). FSP significantly alleviated (P<0.05-0.001) most signs of the metabolic syndrome resulting from experimentally induced type 1 diabetes and obesity by 40-76 and 56-78%, respectively, including hyperglycaemia, hyperlipidaemia, elevation in atherogenic indices, impairment of liver functions, severe changes in body weight and oxidative stress. Besides, FSP (especially the high dose) completely modulated the immunosuppressive activity of CP including leucopenia (resulting from neutropenia and lymphopenia), decrease in weights and cellularity of lymphoid organs, serum gamma-globulin level, delayed type of hypersensitivity response and delay in the skin-burning healing process. FSP decreased the immunosuppressive activity of CP by 57-108%. These beneficial effects of FSP were dose dependent in most cases, and FSP doses used here were considered safe in general. FSP was more efficient in alleviating the signs of the metabolic syndrome in the obese animals (over 9%) than in the type 1 diabetic animals. Moreover, the immunostimulant activity of fenugreek seeds exceeded their anti-metabolic syndrome activity by 15-24%. In conclusion, fenugreek seeds may be useful not only as a dietary adjunct for the control of the metabolic syndrome in diabetic/obese patients, but also as an immunostimulant in immunocompromised patients such as those under chemotherapeutic interventions.
C1 [Ramadan, Gamal; El-Beih, Nadia M.; Abd El-Kareem, Hanaa F.] Ain Shams Univ, Dept Zool, Fac Sci, Cairo 11566, Egypt.
C3 Egyptian Knowledge Bank (EKB); Ain Shams University
RP Ramadan, G (corresponding author), Ain Shams Univ, Dept Zool, Fac Sci, Cairo 11566, Egypt.
EM gamal_ramadan@hotmail.com
RI Abd El-Kareem, Hanaa/AFU-8273-2022; Ramadan, Gamal/A-8666-2012
OI elbeih, Nadia/0009-0000-1523-5222; Ramadan, Gamal/0000-0002-3357-0216
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NR 41
TC 18
Z9 18
U1 1
U2 11
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1145
EI 1475-2662
J9 BRIT J NUTR
JI Br. J. Nutr.
PD APR
PY 2011
VL 105
IS 7
BP 995
EP 1004
DI 10.1017/S0007114510004708
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 739VP
UT WOS:000288748300004
PM 21205429
OA Bronze
DA 2025-06-11
ER

PT S
AU Kuo, LE
   Czarnecka, M
   Kitlinska, JB
   Tilan, JU
   Kvetnansky, R
   Zukowska, Z
AF Kuo, Lydia E.
   Czarnecka, Magdalena
   Kitlinska, Joanna B.
   Tilan, Jason U.
   Kvetnansky, Richard
   Zukowska, Zofia
BE Kvetnansky, R
   Aguilera, G
   Goldstein, D
   Jezova, D
   Krizanova, O
   Sabban, EL
   Pacak, K
TI Chronic Stress, Combined with a High-Fat/High-Sugar Diet, Shifts
   Sympathetic Signaling toward Neuropeptide Y and Leads to Obesity and the
   Metabolic Syndrome
SO STRESS, NEUROTRANSMITTERS, AND HORMONES: NEUROENDOCRINE AND GENETIC
   MECHANISMS
SE Annals of the New York Academy of Sciences
LA English
DT Article; Proceedings Paper
CT 9th Symposium on Catecholamines and Other Neurotransmitters in Stress
CY JUN 16-21, 2007
CL Bethesda, MD
SP Inst Exptl Endocrinol, Ctr Excellence European Commiss, Slovak Acad Sci, Natl Inst Hlth
DE neuropeptide Y; obesity; stress; Y2 receptors; sympathetic system;
   adipogenesis; angiogenesis; metabolic syndrome
ID NPY EXPRESSION; TISSUE; MICE; MEN; RAT
AB In response to stress, some people lose while others gain weight. This is believed to be due to either increased S-adrenergic activation, the body's main fat-burning mechanism, or increased intake of sugar- and fat-rich "comfort foods." A high-fat, high-sugar (HFS) diet alone, however, cannot account for the epidemic of obesity, and chronic stress alone tends to lower adiposity in mice. Here we discuss how chronic stress, when combined with an HFS diet, leads to abdominal obesity by releasing a sympathetic neurotransmitter, neuropeptide Y (NPY), directly into the adipose tissue. In vitro, when "stressed" with dexamethasone, sympathetic neurons shift toward expressing more NPY, which stimulates endothelial cell (angiogenesis) and preadipocyte proliferation, differentiation, and lipid-filling (adipogenesis) by activating the same NPY-Y2 receptors (Y2Rs). In vivo, chronic stress, consisting of cold water or aggression in HFS-fed mice, stimulates the release of NPY and the expression of Y2Rs in visceral fat, increasing its growth by 50% in 2 weeks. After 3 months, this results in metabolic syndrome-like symptoms with abdominal obesity, inflammation, hyperlipidemia, hyperinsulinemia, glucose intolerance, hepatic steatosis, and hypertension. Remarkably, local intra-fat Y2R inhibition pharmacologically or via adenoviral Y2R knock-down reverses or prevents fat accumulation and metabolic complications. These studies demonstrated for the first time that chronic stress, via the NPY-Y2R pathway, amplifies and accelerates diet-induced obesity and the metabolic syndrome. Our findings also suggest the use of local administration of Y2R antagonists for treatment of obesity and NPY-Y2 agonists for fat augmentation in other clinical applications.
C1 [Kuo, Lydia E.; Czarnecka, Magdalena; Kitlinska, Joanna B.; Tilan, Jason U.; Zukowska, Zofia] Georgetown Univ, Med Ctr, Dept Physiol & Biophys, Washington, DC 20057 USA.
   [Kvetnansky, Richard] Slovak Acad Sci, Inst Expt Endocrinol, Bratislava, Slovakia.
C3 Georgetown University; Slovak Academy of Sciences; Institute of
   Experimental Endocrinology, SAS
RP Zukowska, Z (corresponding author), Georgetown Univ, Med Ctr, Dept Physiol & Biophys, 3900 Reservoir Rd NW, Washington, DC 20057 USA.
EM zzukow01@georgetown.edu
RI Tilan, Justin/AAJ-7253-2021
OI Tilan, Jason/0000-0002-0454-5409
FU NIHBL [HL067357, HL055310]; American Heart Association; Slovak Research
   Agency [APVV-0148-06]
FX We wish to thank all the members of the NPY Lab and other departments of
   Georgetown University Medical Center who contributed to this work. This
   work was supported by Grants HL067357 and HL055310 from the NIHBL (to
   Z.Z.), a pre-doctoral fellowship from the American Heart Association (to
   L.K.), and was also supported by Slovak Research Agency Grant
   APVV-0148-06.
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NR 23
TC 122
Z9 140
U1 1
U2 19
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN STREET, MALDEN 02148, MA USA
SN 0077-8923
BN 978-1-57331-692-7
J9 ANN NY ACAD SCI
JI Ann.NY Acad.Sci.
PY 2008
VL 1148
BP 232
EP 237
DI 10.1196/annals.1410.035
PG 6
WC Endocrinology & Metabolism; Multidisciplinary Sciences; Neurosciences;
   Physiology
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Science & Technology - Other Topics;
   Neurosciences & Neurology; Physiology
GA BIS00
UT WOS:000262398300028
PM 19120115
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Potz, BA
   Sabe, SA
   Scrimgeour, LA
   Sabe, AA
   Harris, DD
   Abid, MR
   Clements, RT
   Sellke, FW
AF Potz, Brittany A.
   Sabe, Sharif A.
   Scrimgeour, Laura A.
   Sabe, Ashraf A.
   Harris, Dwight D.
   Abid, M. Ruhul
   Clements, Richard T.
   Sellke, Frank W.
TI Calpain inhibition decreases oxidative stress via mitochondrial
   regulation in a swine model of chronic myocardial ischemia
SO FREE RADICAL BIOLOGY AND MEDICINE
LA English
DT Article
DE Calpain; Chronic coronary ischemia; Metabolic syndrome; Oxidative stress
ID DIABETES-MELLITUS; ENDOTHELIAL DYSFUNCTION; SUPEROXIDE-DISMUTASE;
   REPERFUSION INJURY; INDUCED APOPTOSIS; HEART; PROTECTS; CALCIUM
AB Introduction: Calpain overexpression is implicated in mitochondrial damage leading to tissue oxidative stress and myocardial ischemic injury. The aim of this study was to determine the effects of calpain inhibition (CI) on mitochondrial impairment and oxidative stress in a swine model of chronic myocardial ischemia and metabolic syndrome. Methods: Yorkshire swine were fed a high-fat diet for 4 weeks to induce metabolic syndrome then underwent placement of an ameroid constrictor to the left circumflex artery. Three weeks later, animals received: no drug (control, "CON"; n= 7); a low-dose calpain inhibitor (0.12 mg/kg; "LCI", n= 7); or high-dose calpain inhibitor (0.25 mg/kg; "HCI", n=7). Treatment continued for 5 weeks, followed by tissue harvest. Cardiac tissue was assayed for protein carbonyl content, as well as antioxidant and mitochondrial protein expression. Reactive oxygen species (ROS) and mitochondrial respiration was measured in H9c2 cells following exposure to normoxia or hypoxia (1%) for 24 h with or without CI. Results: In ischemic myocardial tissue, CI was associated with decreased total oxidative stress compared to control. CI was also associated with increased expression of mitochondrial proteins superoxide dismutase 1, SDHA, and pyruvate dehydrogenase compared to control. 100 nM of calpain inhibitor decreased ROS levels and respiration in both normoxic and hypoxic H9c2 cardiomyoblasts. Conclusions: In the setting of metabolic syndrome, CI improves oxidative stress in chronically ischemic myocardial tissue. Decreased oxidative stress may be via modulation of mitochondrial proteins involved in free radical scavenging and production.
C1 [Potz, Brittany A.; Sabe, Sharif A.; Scrimgeour, Laura A.; Sabe, Ashraf A.; Harris, Dwight D.; Abid, M. Ruhul; Clements, Richard T.; Sellke, Frank W.] Brown Univ, Alpert Med Sch, Rhode Island Hosp, Div Cardiothorac Surg,Dept Surg,Cardiovasc Res Ctr, Providence, RI USA.
   [Sellke, Frank W.] Brown Univ, Rhode Isl Hosp, Cardiovasc Res Ctr, Dept Surg,Div Cardiothorac Surg,Alpert Med Sch, 2 Dudley St,MOC 360, Providence, RI 02905 USA.
C3 Lifespan Health Rhode Island; Rhode Island Hospital; Brown University;
   Brown University; Lifespan Health Rhode Island; Rhode Island Hospital
RP Sellke, FW (corresponding author), Brown Univ, Rhode Isl Hosp, Cardiovasc Res Ctr, Dept Surg,Div Cardiothorac Surg,Alpert Med Sch, 2 Dudley St,MOC 360, Providence, RI 02905 USA.
EM fsellke@lifespan.org
OI sellke, frank/0000-0002-8886-801X; Sabe, Sharif/0000-0002-8169-6753
FU National Heart, Lung, and Blood Institute (NHLBI) [2T32 GM065085,
   1F32HL160063]
FX Funding for this research was provided by the National Heart, Lung, and
   Blood Institute (NHLBI) 2T32 GM065085 (B.A.P.) ; 1F32HL160063-
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NR 40
TC 1
Z9 1
U1 0
U2 4
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0891-5849
EI 1873-4596
J9 FREE RADICAL BIO MED
JI Free Radic. Biol. Med.
PD NOV 1
PY 2023
VL 208
BP 700
EP 707
DI 10.1016/j.freeradbiomed.2023.09.028
EA SEP 2023
PG 8
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA U6RN8
UT WOS:001086058000001
PM 37748718
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Tain, YL
   Hsu, CN
AF Tain, You-Lin
   Hsu, Chien-Ning
TI Metabolic Syndrome Programming and Reprogramming: Mechanistic Aspects of
   Oxidative Stress
SO ANTIOXIDANTS
LA English
DT Review
DE oxidative stress; reactive oxygen species; antioxidant; developmental
   origins of health and disease (DOHaD); nitric oxide; obesity;
   hypertension; metabolic syndrome
ID IN-UTERO EXPOSURE; LOW-BIRTH-WEIGHT; REDUCES NEPHRON NUMBER;
   NITRIC-OXIDE SYNTHESIS; CATCH-UP GROWTH; HIGH-FAT DIET; BLOOD-PRESSURE;
   SUPPLEMENTATION PREVENTS; DEVELOPMENTAL ORIGINS; EARLY-LIFE
AB Metabolic syndrome (MetS) is a worldwide public health issue characterized by a set of risk factors for cardiovascular disease. MetS can originate in early life by developmental programming. Increasing evidence suggests that oxidative stress, which is characterized as an imbalance between reactive oxygen species (ROS), nitric oxide (NO), and antioxidant systems, plays a decisive role in MetS programming. Results from human and animal studies indicate that maternal-derived insults induce MetS later in life, accompanied by oxidative stress programming of various organ systems. On the contrary, perinatal use of antioxidants can offset oxidative stress and thereby prevent MetS traits in adult offspring. This review provides an overview of current knowledge about the core mechanisms behind MetS programming, with particular focus on the occurrence of oxidative-stress-related pathogenesis as well as the use of potential oxidative-stress-targeted interventions as a reprogramming strategy to avert MetS of developmental origins. Future clinical studies should provide important proof of concept for the effectiveness of these reprogramming interventions to prevent a MetS epidemic.
C1 [Tain, You-Lin] Kaohsiung Chang Gung Mem Hosp, Dept Pediat, Kaohsiung 833, Taiwan.
   [Tain, You-Lin] Chang Gung Univ, Coll Med, Taoyuan 333, Taiwan.
   [Hsu, Chien-Ning] Kaohsiung Chang Gung Mem Hosp, Dept Pharm, Kaohsiung 833, Taiwan.
   [Hsu, Chien-Ning] Kaohsiung Med Univ, Sch Pharm, Kaohsiung 807, Taiwan.
C3 Chang Gung Memorial Hospital; Chang Gung University; Chang Gung Memorial
   Hospital; Kaohsiung Medical University
RP Hsu, CN (corresponding author), Kaohsiung Chang Gung Mem Hosp, Dept Pharm, Kaohsiung 833, Taiwan.; Hsu, CN (corresponding author), Kaohsiung Med Univ, Sch Pharm, Kaohsiung 807, Taiwan.
EM cnhsu@cgmh.org.tw
RI Hsu, Chien-Ning/GLS-4014-2022; Tain, You-Lin/H-2827-2019
OI Tain, You-Lin/0000-0002-7059-6407; Hsu, Chien-Ning/0000-0001-7470-528X
FU Chang Gung Memorial Hospital, Kaohsiung, Taiwan [CMRPG8M0721,
   CORPG8M0201, CORPG8M0151, CORPG8M0081]
FX This work was supported by Chang Gung Memorial Hospital, Kaohsiung,
   Taiwan, grants CMRPG8M0721, CORPG8M0201, CORPG8M0151, and CORPG8M0081.
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NR 212
TC 15
Z9 15
U1 1
U2 11
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD NOV
PY 2022
VL 11
IS 11
AR 2108
DI 10.3390/antiox11112108
PG 23
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA 6A5VP
UT WOS:000880723300001
PM 36358480
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Llano-Diez, M
   Sinclair, J
   Yamada, T
   Zong, M
   Fauconnier, J
   Zhang, SJ
   Katz, A
   Jardemark, K
   Westerblad, H
   Andersson, DC
   Lanner, JT
AF Llano-Diez, Monica
   Sinclair, Jon
   Yamada, Takashi
   Zong, Mei
   Fauconnier, Jeremy
   Zhang, Shi-Jin
   Katz, Abram
   Jardemark, Kent
   Westerblad, Hakan
   Andersson, Daniel C.
   Lanner, Johanna T.
TI The Role of Reactive Oxygen Species in β-Adrenergic Signaling in
   Cardiomyocytes from Mice with the Metabolic Syndrome
SO PLOS ONE
LA English
DT Article
ID SKELETAL-MUSCLE FIBERS; HEART-FAILURE; OXIDATIVE STRESS; MITOCHONDRIAL
   DYSFUNCTION; CA2+ CHANNEL; CARDIAC CONTRACTILITY; RECEPTOR STIMULATION;
   HIGH-FAT; INSULIN; OB/OB
AB The metabolic syndrome is associated with prolonged stress and hyperactivity of the sympathetic nervous system and afflicted subjects are prone to develop cardiovascular disease. Under normal conditions, the cardiomyocyte response to acute beta-adrenergic stimulation partly depends on increased production of reactive oxygen species (ROS). Here we investigated the interplay between beta-adrenergic signaling, ROS and cardiac contractility using freshly isolated cardiomyocytes and whole hearts from two mouse models with the metabolic syndrome (high-fat diet and ob/ob mice). We hypothesized that cardiomyocytes of mice with the metabolic syndrome would experience excessive ROS levels that trigger cellular dysfunctions. Fluorescent dyes and confocal microscopy were used to assess mitochondrial ROS production, cellular Ca2+ handling and contractile function in freshly isolated adult cardiomyocytes. Immunofluorescence, western blot and enzyme assay were used to study protein biochemistry. Unexpectedly, our results point towards decreased cardiac ROS signaling in a stable, chronic phase of the metabolic syndrome because: beta-adrenergic-induced increases in the amplitude of intracellular Ca2+ signals were insensitive to antioxidant treatment; mitochondrial ROS production showed decreased basal rate and smaller response to beta-adrenergic stimulation. Moreover, control hearts and hearts with the metabolic syndrome showed similar basal levels of ROS-mediated protein modification, but only control hearts showed increases after beta-adrenergic stimulation. In conclusion, in contrast to the situation in control hearts, the cardiomyocyte response to acute beta-adrenergic stimulation does not involve increased mitochondrial ROS production in a stable, chronic phase of the metabolic syndrome. This can be seen as a beneficial adaptation to prevent excessive ROS levels.
C1 [Llano-Diez, Monica; Sinclair, Jon; Yamada, Takashi; Fauconnier, Jeremy; Zhang, Shi-Jin; Katz, Abram; Jardemark, Kent; Westerblad, Hakan; Lanner, Johanna T.] Karolinska Inst, Dept Physiol & Pharmacol, Stockholm, Sweden.
   [Zong, Mei] Karolinska Univ Hosp, Rheumatol Unit, CMM, Stockholm, Sweden.
   [Andersson, Daniel C.] Karolinska Inst, Dept Med, Stockholm, Sweden.
   [Yamada, Takashi] Sapporo Med Univ, Grad Sch Hlth Sci, Sapporo, Hokkaido, Japan.
   [Fauconnier, Jeremy] Univ Montpellier, INSERM, U1046, Montpellier, France.
   [Katz, Abram] Ariel Univ, Sch Hlth Sci, Dept Phys Therapy, Ariel, Israel.
C3 Karolinska Institutet; Karolinska Institutet; Karolinska University
   Hospital; Karolinska Institutet; Sapporo Medical University; Institut
   National de la Sante et de la Recherche Medicale (Inserm); Universite de
   Montpellier; Ariel University
RP Lanner, JT (corresponding author), Karolinska Inst, Dept Physiol & Pharmacol, Stockholm, Sweden.
EM Johanna.Lanner@ki.se
RI 山田, 崇史/U-8443-2019; Katz, Abram/AAL-2244-2020; Westerblad,
   HÃ¥kan/NFS-7447-2025; Lanner, Johanna/HKE-8374-2023; Fauconnier,
   Jeremy/N-6233-2018; Andersson, Daniel/AAE-9968-2019
OI Westerblad, Hakan/0000-0002-8180-3029; Fauconnier,
   Jeremy/0000-0003-2748-0983; Llano-Diez, Monica/0000-0002-9791-0267;
   Yamada, Takashi/0000-0003-1797-3880; Andersson,
   Daniel/0000-0003-4548-702X
FU Swedish Research Council; Swedish Heart-Lung Foundation; KI fonds; Ake
   Wiberg foundation; Stockholm County Council; Karolinska Institutet; Lars
   Hierta foundation; Grants-in-Aid for Scientific Research [15K12585,
   26702021] Funding Source: KAKEN
FX This study was supported by The Swedish Research Council (JTL, HW), the
   Swedish Heart-Lung Foundation (DCA, HW), KI fonds (JTL), Ake Wiberg
   foundation (JTL, DCA), Regional Agreement on Medical Training and
   Clinical Research (ALF) between Stockholm County Council and Karolinska
   Institutet (DCA) and Lars Hierta foundation (ML-D). The funders had no
   role in study design, data collection and analysis, decision to publish,
   or preparation of the manuscript.
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NR 64
TC 18
Z9 18
U1 0
U2 5
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD DEC 1
PY 2016
VL 11
IS 12
AR e0167090
DI 10.1371/journal.pone.0167090
PG 16
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA EE3JC
UT WOS:000389482700075
PM 27907040
OA Green Submitted, gold, Green Published
DA 2025-06-11
ER

PT J
AU Palmiero, P
   Maiello, M
   Amati, F
   Ciccone, MM
   Paul, T
AF Palmiero, Pasquale
   Maiello, Maria
   Amati, Francesca
   Ciccone, Marco Matteo
   Paul, Timir
TI Association between metabolic syndrome, hypertension, and chronic
   depression: a postmenopausal women prevention study
SO ITALIAN JOURNAL OF MEDICINE
LA English
DT Article
DE postmenopausal women; metabolic syndrome; hypertension; depression;
   cardiomyopathy
ID CARDIOVASCULAR-DISEASE; MANAGEMENT
AB Background. Chronic depression (CD) is common among postmenopausal women and is associated with an increased risk of cardiovascular disease (CVD). The diagnosis of CD is a challenging problem in clinical practice which is vastly under-diagnosed. CD detection in postmenopausal women with metabolic syndrome (MetS) or hypertension is necessary for CVD prevention. Our study aims to assess the prevalence of CD in postmenopausal women and the relationship between CD and MetS or hypertension. Results. The rate of CD was significantly higher among postmenopausal women with MetS compared with the control group [18% versus 8%; Odds ratio (OR) 2.2, P<0.007]. The CD rate was significantly higher among women with MetS and hypertension (21% versus 8%; OR 2.7, P<0.0000). The rate of CD was similar between women with MetS and women with hypertension, 18% versus 21%; OR 0.8, P<0.44) and between women with metabolic cardiomyopathy and hypertensive cardiomyopathy (10% versus 8%; OR 1.1, P<0.65). Conclusions. There is a relationship between MetS and CD, which is stronger when compared to women with hypertension. There is a need to improve the diagnosis of CD in postmenopausal women with MetS or hypertension as unrecognized and untreated CD is associated with a poor outcome.
C1 [Palmiero, Pasquale; Maiello, Maria] ASL Brindisi, Cardiol Equipe, Brindisi, Italy.
   [Palmiero, Pasquale] Univ Bari, Med Sch, Bari, Italy.
   [Amati, Francesca; Ciccone, Marco Matteo] Univ Bari, Cardiovasc Dis, Dept Emergency & Organ Transplantat DETO, Bari, Italy.
   [Paul, Timir] Univ Tennessee Nashville, Ascens St Thomas Hosp, Nashville, TN USA.
C3 Universita degli Studi di Bari Aldo Moro; Universita degli Studi di Bari
   Aldo Moro; University of Tennessee System; University of Tennessee
   Knoxville
RP Palmiero, P (corresponding author), ASL Brindisi, Cardiol Equipe, Via Francia 47, I-72100 Brindisi, Italy.
EM pasqualepalmiero@yahoo.it
RI Palmiero, Pasquale/F-4200-2016; Ciccone, Marco/C-5271-2013
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NR 30
TC 0
Z9 0
U1 0
U2 1
PU PAGEPRESS PUBL
PI PAVIA
PA MEDITGROUP, VIA G BELLI, 4, PAVIA, 27100, ITALY
SN 1877-9344
EI 1877-9352
J9 ITAL J MED
JI Ital. J. Med.
PY 2023
VL 17
IS 1
AR 1624
DI 10.4081/itjm.2023.1624
PG 5
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA M6RB5
UT WOS:001031458000008
OA gold
DA 2025-06-11
ER

PT J
AU Violanti, JM
   Fekedulegn, D
   Burchfiel, CM
   McCanlies, E
   Service, SK
   Mnatsakanova, A
   Gu, JK
   Allison, P
   Andrew, ME
   Charles, LE
AF Violanti, John M.
   Fekedulegn, Desta
   Burchfiel, Cecil M.
   McCanlies, Erin
   Service, Samantha K.
   Mnatsakanova, Anna
   Gu, Ja K.
   Allison, Penelope
   Andrew, Micheal E.
   Charles, Luenda E.
TI Buffalo Cardio-Metabolic Occupational Police Stress (BCOPS) study: a
   seven- and twelve-year prospective analysis of occupational exposures
   and health outcomes among police officers
SO INTERNATIONAL ARCHIVES OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH
LA English
DT Article; Early Access
DE Police officers; Health; Cardiovascular disease; PTSD; Depression;
   Stress
ID CARDIOVASCULAR-DISEASE; RISK-FACTORS; WORK HOURS; MORBIDITY; HOSTILITY;
   SHIFTWORK; ANXIETY; GENDER; SCALE; LONG
AB ObjectiveOverall, police officers have higher rates of several adverse health conditions (e.g., cardiovascular health profiles and post-traumatic stress disorder (PTSD)) compared to persons in many other occupations. Our objective was to conduct a comparative study of occupational exposures and health outcomes among police officers across: (a) a 7-year period, from the baseline examination (2004-2009) to the 1st follow-up examination (2011-2015) and (b) a 12-year period, from baseline to the 2nd follow-up examination (2015-2019).MethodsParticipants were from the Buffalo Cardio-Metabolic Occupational Police Stress (BCOPS) Study. Variables were assessed through self-report, standardized validated questionnaires, or standardized medical procedures. We computed the 7- and 12-year changes in mean values (for continuous/numeric variables) or prevalence (for categorical variables) and the corresponding 95% confidence intervals (CIs) using MIXED and GENMOD procedures in SAS.ResultsOccupational stress significantly increased over 12 years [3.4; (95% CI 1.2, 5.6)]. The percentage of officers who reported excellent/very good health significantly decreased across both time periods: [- 11.8%; (- 17.8, - 5.9)] across seven years and [- 17.3%; (- 24.2, - 10.4)] across 12 years. The prevalence of metabolic syndrome increased over seven years [10.7%; (5.3-16.0)] and over 12 years [7.4%; (0.1-14.0)]. Abdominal obesity and glucose intolerance significantly increased over both time periods while hypertension and elevated triglyceride levels increased slightly but not significantly over both time periods.ConclusionOccupational stressors and some health outcomes of officers worsened over time indicating the need for self-health monitoring and wellness programs for police.
C1 [Violanti, John M.] SUNY Buffalo, Sch Publ Hlth & Hlth Profess, Dept Epidemiol & Environm Hlth, Buffalo, NY 14260 USA.
   [Fekedulegn, Desta; Burchfiel, Cecil M.; McCanlies, Erin; Service, Samantha K.; Mnatsakanova, Anna; Gu, Ja K.; Allison, Penelope; Charles, Luenda E.] CDCP, Natl Inst Occupat Safety & Hlth, Hlth Effects Lab Div, Morgantown, WV USA.
   [Andrew, Micheal E.] West Virginia Univ, Fac & Staff Assistance Program, Dept Behav Med & Psychiat, Morgantown, WV USA.
C3 State University of New York (SUNY) System; University at Buffalo, SUNY;
   Centers for Disease Control & Prevention - USA; National Institute for
   Occupational Safety & Health (NIOSH); West Virginia University
RP Violanti, JM (corresponding author), SUNY Buffalo, Sch Publ Hlth & Hlth Profess, Dept Epidemiol & Environm Hlth, Buffalo, NY 14260 USA.
EM violanti@buffalo.edu
FU National Institute for Occupational Safety and Health (NIOSH)
   [200-2003-01580, 1R01OH 009640-01A1, 1R01OH010807-01]
FX This work was supported by the National Institute for Occupational
   Safety and Health (NIOSH), contract no. 200-2003-01580 and grant numbers
   1R01OH 009640-01A1 and 1R01OH010807-01.
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NR 62
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0340-0131
EI 1432-1246
J9 INT ARCH OCC ENV HEA
JI Int. Arch. Occup. Environ. Health
PD 2025 MAY 23
PY 2025
DI 10.1007/s00420-025-02142-x
EA MAY 2025
PG 15
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA 2XA9G
UT WOS:001493355700001
PM 40407845
DA 2025-06-11
ER

PT J
AU Kolman, L
   Shin, NM
   Krishnan, SM
   Schwartz, S
   Gracik, T
   Jackson, EA
   Rubenfire, M
AF Kolman, Louis
   Shin, Nah-Mee
   Krishnan, Sangeetha M.
   Schwartz, Steven
   Gracik, Theresa
   Jackson, Elizabeth A.
   Rubenfire, Melvyn
TI Psychological Distress in Cardiac Rehabilitation Participants
SO JOURNAL OF CARDIOPULMONARY REHABILITATION AND PREVENTION
LA English
DT Article
DE cardiac rehabilitation; depression; psychological distress; SCL-90
ID CORONARY-HEART-DISEASE; ARTERY-DISEASE; MYOCARDIAL-INFARCTION; CAROTID
   ATHEROSCLEROSIS; CARDIOVASCULAR-DISEASE; RISK-FACTORS; DEPRESSION;
   HOSTILITY; MORTALITY; ANXIETY
AB PURPOSE: Limited data are available on the psychosocial characteristics of patients entering cardiac rehabilitation (CR). We characterized the psychological and clinical profiles of men and women entering CR to determine which, if any, characteristic identifies persons at high risk for psychological distress.
   METHODS: The records of 417 patients enrolled in phase II CR between January 2001 and December 2004 were analyzed. One hundred fortyeight of these patients underwent a comprehensive Symptom Checklist-90 psychological survey. The analysis focused on measures of depression, anxiety, hostility, somatization, and a global severity index.
   RESULTS: Mean age of the patients was 60.6 years and 20.9% of them were women. More than one-third had a score of 90th percentile or more in at least 1 psychological category, and 23% had a score of 90th percentile or more in 3 or more categories. Approximately 20% and 36% of patients scoring in the 90th percentile or more and 98th percentile or more of depressive symptoms, respectively, had a history of depression. There was no difference in Symptom Checklist-90 scores by gender, age, education, work status, type of coronary event, metabolic syndrome, tobacco use, cerebrovascular disease, peripheral vascular disease, or diabetes. There was no relationship between psychological symptoms and indication for CR, although a trend of more somatic symptoms was seen in those who underwent an acute coronary syndrome and did not receive revascularization.
   CONCLUSION: Considering the prevalence of psychological distress in CR patients and the lack of clinical identifiers, routine assessment could help identify those who are at increased risk of noncompliance and may benefit from psychological and/or pharmacological intervention.
C1 [Kolman, Louis; Shin, Nah-Mee; Krishnan, Sangeetha M.; Schwartz, Steven; Gracik, Theresa; Jackson, Elizabeth A.; Rubenfire, Melvyn] Univ Michigan, Dept Internal Med, Div Cardiovasc Med, Ann Arbor, MI 48109 USA.
C3 University of Michigan System; University of Michigan
RP Rubenfire, M (corresponding author), 24 Frank Lloyd Wright Dr, Ann Arbor, MI 48106 USA.
EM mrubenfi@umich.edu
RI Jackson, Elizabeth/I-7999-2013
OI Jackson, Elizabeth/0000-0002-5086-0418
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NR 34
TC 6
Z9 6
U1 0
U2 11
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1932-7501
EI 1932-751X
J9 J CARDIOPULM REHABIL
JI J. Cardiopulm. Rehabil. Prev.
PD MAR-APR
PY 2011
VL 31
IS 2
BP 81
EP 86
DI 10.1097/HCR.0b013e3181f688e1
PG 6
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Cardiovascular System & Cardiology
GA 726PD
UT WOS:000287736700002
PM 21045712
DA 2025-06-11
ER

PT J
AU Bryan, S
   Baregzay, B
   Spicer, D
   Singal, PK
   Khaper, N
AF Bryan, Sean
   Baregzay, Boran
   Spicer, Drew
   Singal, Pawan K.
   Khaper, Neelam
TI Redox-inflammatory synergy in the metabolic syndrome
SO CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
LA English
DT Review
DE metabolic syndrome; oxidative stress; inflammation; obesity; diabetes;
   dyslipidemia; atherosclerosis; hypertension
ID LOW-DENSITY-LIPOPROTEIN; GLYCATION END-PRODUCTS; NF-KAPPA-B; INDUCED
   INSULIN-RESISTANCE; TYPE-2 DIABETES-MELLITUS; RENIN-ANGIOTENSIN SYSTEM;
   OXIDATIVE STRESS; ADIPOSE-TISSUE; NADPH OXIDASE; ENDOTHELIAL DYSFUNCTION
AB Metabolic syndrome (MetS) comprises interrelated disease states including obesity, insulin resistance and type 2 diabetes (T2DM), dyslipidemia, and hypertension. Essential to normal physiological function, and yet massively damaging in excess, oxidative stress and inflammation are pivotal common threads among the pathologies of MetS. Increasing evidence indicates that redox and inflammatory dysregulation parallels the syndrome's physiological, biochemical, and anthropometric features, leading many to consider the pro-oxidative, pro-inflammatory milieu an unofficial criterion in itself. Left unchecked, cross-promotion of oxidative stress and inflammation creates a feed-forward cycle that can initiate and advance disease progression. Such redox-inflammatory integration is evident in the pathogenesis of obesity, insulin resistance and T2DM, atherogenic dyslipidemia, and hypertension, and is thus hypothesized to be the "common soil" from which they develop. The present review highlights the synergistic contributions of redox-inflammatory processes to each of the components of the MetS.
C1 [Bryan, Sean; Spicer, Drew; Khaper, Neelam] Lakehead Univ, Div Med Sci, No Ontario Sch Med, Thunder Bay, ON P7B 5E1, Canada.
   [Baregzay, Boran] Lakehead Univ, Dept Biol, Thunder Bay, ON P7B 5E1, Canada.
   [Singal, Pawan K.] Univ Manitoba, Inst Cardiovasc Sci, St Boniface Gen Hosp Res Ctr, Winnipeg, MB R2H 2A6, Canada.
C3 Lakehead University; NOSM University; Lakehead University; University of
   Manitoba; Children's Hospital Research Institute of Manitoba
RP Khaper, N (corresponding author), Lakehead Univ, Div Med Sci, No Ontario Sch Med, 955 Oliver Rd, Thunder Bay, ON P7B 5E1, Canada.
EM nkhaper@nosm.ca
FU Northern Ontario School of Medicine; Canadian Institute for Health
   Research; Northern Ontario School of Medicine Summer Research Award;
   Naranjan S. Dhalla Chair in Cardiovascular Research; St. Boniface
   Hospital & Research Foundation
FX Support from the Northern Ontario School of Medicine (Dr. Khaper) and
   Canadian Institute for Health Research (Dr. Singal) is gratefully
   acknowledged. Sean Bryan was supported by a Northern Ontario School of
   Medicine Summer Research Award. Dr. Pawan K. Singal holds the Naranjan
   S. Dhalla Chair in Cardiovascular Research, supported by the St.
   Boniface Hospital & Research Foundation.
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NR 112
TC 60
Z9 63
U1 0
U2 15
PU CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS
PI OTTAWA
PA 65 AURIGA DR, SUITE 203, OTTAWA, ON K2E 7W6, CANADA
SN 0008-4212
EI 1205-7541
J9 CAN J PHYSIOL PHARM
JI Can. J. Physiol. Pharmacol.
PD JAN
PY 2013
VL 91
IS 1
BP 22
EP 30
DI 10.1139/cjpp-2012-0295
PG 9
WC Pharmacology & Pharmacy; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Physiology
GA 081YE
UT WOS:000314357800005
PM 23368637
DA 2025-06-11
ER

PT J
AU Vazquez-Prieto, MA
   González, RE
   Renna, NF
   Galmarini, CR
   Miatello, RM
AF Alejandra Vazquez-Prieto, Marcela
   Elizabeth Gonzalez, Roxana
   Federico Renna, Nicolas
   Romulo Galmarini, Claudio
   Miguel Miatello, Roberto
TI Aqueous Garlic Extracts Prevent Oxidative Stress and Vascular Remodeling
   in an Experimental Model of Metabolic Syndrome
SO JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
LA English
DT Article
DE Allium sativum; metabolic syndrome; oxidative stress; vascular
   remodeling
ID INSULIN-RESISTANCE; HYPERTENSION; ALLICIN; ALLIUM; AGENT; INFLAMMATION;
   ANTIOXIDANT; INHIBITION; EXPRESSION; OXIDASE
AB The organosulfur profile and the effect on oxidative stress and vascular remodeling in fructose-fed rats (FFR) were evaluated in Fuego INTA and Morado INTA garlic cultivars. Wistar rats were fed either normal rat chow (control) or the same diet plus 10% fructose in drinking water. During the last 6 weeks of a 12 week period of the corresponding diet, a subgroup of control and FFR received an aqueous extract of Fuego INTA and Morado INTA. Fuego INTA showed higher levels of total thiosulfinates, allicin, and pungency than Morado INTA. FFR showed an increase of systolic blood pressure, aortic NAD(P)H oxidase activity, plasma thiobarbituric acid reactive substances, and vascular remodeling that was significantly reduced after both garlic administrations. The beneficial effect was slightly higher when Fuego INTA was administered. Both aqueous garlic extracts prevent oxidative stress and vascular remodeling in rats with metabolic syndrome, suggesting the existence of slight differences among cultivars.
C1 [Alejandra Vazquez-Prieto, Marcela; Federico Renna, Nicolas; Miguel Miatello, Roberto] Univ Nacl Cuyo, Fac Ciencias Med, Area Fisiol Patol, RA-5500 Mendoza, Argentina.
   [Alejandra Vazquez-Prieto, Marcela; Federico Renna, Nicolas; Miguel Miatello, Roberto] Consejo Nacl Invest Cient & Tecn, IMBECU, RA-5500 Mendoza, Argentina.
   [Elizabeth Gonzalez, Roxana; Romulo Galmarini, Claudio] Univ Nacl Cuyo, Fac Ciencias Agr, RA-5505 Mendoza, Argentina.
   [Romulo Galmarini, Claudio] EEA INTA La Consulta, RA-5567 Mendoza, Argentina.
C3 University Nacional Cuyo Mendoza; Consejo Nacional de Investigaciones
   Cientificas y Tecnicas (CONICET); Instituto de Medicina y BiologIa
   Experimental de Cuyo (IMBECU); University Nacional Cuyo Mendoza;
   Instituto Nacional de Tecnologia Agropecuaria (INTA)
RP Miatello, RM (corresponding author), Univ Nacl Cuyo, Fac Ciencias Med, Area Fisiol Patol, Av Libertador 80, RA-5500 Mendoza, Argentina.
EM rmiatell@fcm.uncu.edu.ar
RI Prieto, Marcela/W-4291-2019; Gonzalez, Roxana/HKN-7930-2023
OI Gonzalez, Roxana/0000-0002-8072-9920; Galmarini,
   Claudio/0000-0002-7958-0110
FU National University of Cuyo [PICTO 08-12902, 06/P01]
FX Received for review November 10, 2009. Revised manuscript received April
   21, 2010. Accepted April 26, 2010. This study was supported by PICTO
   08-12902 and Program I+D 06/P01 of the National University of Cuyo.
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NR 42
TC 34
Z9 37
U1 0
U2 9
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0021-8561
EI 1520-5118
J9 J AGR FOOD CHEM
JI J. Agric. Food Chem.
PD JUN 9
PY 2010
VL 58
IS 11
BP 6630
EP 6635
DI 10.1021/jf1006819
PG 6
WC Agriculture, Multidisciplinary; Chemistry, Applied; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture; Chemistry; Food Science & Technology
GA 602OU
UT WOS:000278149500013
PM 20450156
OA Green Published
DA 2025-06-11
ER

PT J
AU Soltani, Z
   Rasheed, K
   Kapusta, DR
   Reisin, E
AF Soltani, Zohreh
   Rasheed, Kashaf
   Kapusta, Daniel R.
   Reisin, Efrain
TI Potential Role of Uric Acid in Metabolic Syndrome, Hypertension, Kidney
   Injury, and Cardiovascular Diseases: Is It Time for Reappraisal?
SO CURRENT HYPERTENSION REPORTS
LA English
DT Article
DE Uric acid; Hyperuricemia; Fructose; Metabolic syndrome; Obesity;
   Hypertension; Kidney disease; Cardiovascular disorder
ID CORONARY-HEART-DISEASE; IMPROVES ENDOTHELIAL FUNCTION; NUTRITION
   EXAMINATION SURVEY; BLOOD-PRESSURE; OXIDATIVE STRESS; RISK-FACTORS;
   PROGNOSTIC-SIGNIFICANCE; INDEPENDENT PREDICTOR; SWEETENED BEVERAGES;
   CELL-PROLIFERATION
AB Elevated serum uric acid concentration is a common laboratory finding in subjects with metabolic syndrome/obesity, hypertension, kidney disease and cardiovascular events. Hyperuricemia has been attributed to hyperinsulinemia in metabolic syndrome and to decreased uric acid excretion in kidney dysfunction, and is not acknowledged as a main mediator of metabolic syndrome, renal disease, and cardiovascular disorder development. However, more recent investigations have altered this traditional view and shown, by providing compelling evidence, to support an independent link between hyperuricemia and increased risk of metabolic syndrome, diabetes, hypertension, kidney disease and cardiovascular disorders. However, despite these new findings, controversy regarding the exact role of uric acid in inducing these diseases remains to be unfolded. Furthermore, recent data suggest that the high-fructose diet in the United State, as a major cause of hyperuricemia, may be contributing to the metabolic syndrome/obesity epidemic, diabetes, hypertension, kidney disease and cardiovascular disorder. Our focus in this review is to discuss the available evidence supporting a role for uric acid in the development of metabolic syndrome, hypertension, renal disease, and cardiovascular disorder; and the potential pathophysiology mechanisms involved.
C1 [Soltani, Zohreh; Rasheed, Kashaf; Reisin, Efrain] Louisiana State Univ, Hlth Sci Ctr, Sect Nephrol & Hypertens, New Orleans, LA 70112 USA.
   [Kapusta, Daniel R.] Louisiana State Univ, Hlth Sci Ctr, Dept Pharmacol, New Orleans, LA 70112 USA.
C3 Louisiana State University System; Louisiana State University Health
   Sciences Center New Orleans; Louisiana State University System;
   Louisiana State University Health Sciences Center New Orleans
RP Soltani, Z (corresponding author), Louisiana State Univ, Hlth Sci Ctr, Sect Nephrol & Hypertens, 1542 Tulane Ave,Room 330A, New Orleans, LA 70112 USA.
EM zsolta@lsuhsc.edu
FU National Institutes of Health [8P20 GM103514, P20 RR018766]; American
   Heart Association [12GRNT12060613]; American Heart Association (AHA)
   [12GRNT12060613] Funding Source: American Heart Association (AHA)
FX This work was supported by National Institutes of Health grants 8P20
   GM103514 and P20 RR018766 (to Z. Soltani and D. R. Kapusta) and American
   Heart Association grant 12GRNT12060613 (to D. R. Kapusta).
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NR 98
TC 207
Z9 226
U1 1
U2 55
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1522-6417
EI 1534-3111
J9 CURR HYPERTENS REP
JI Curr. Hypertens. Rep.
PD JUN
PY 2013
VL 15
IS 3
BP 175
EP 181
DI 10.1007/s11906-013-0344-5
PG 7
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 142RL
UT WOS:000318814700008
PM 23588856
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Abdulghani, MF
   Al-Fayyadh, S
AF Abdulghani, Mohammed Faris
   Al-Fayyadh, Sadeq
TI Natural products for managing metabolic syndrome: a scoping review
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Review
DE natural products; plants; complementary and alternative medicine;
   metabolic syndrome; scoping review
ID VITAMIN-D SUPPLEMENTATION; HIGH-FAT DIET; OXIDATIVE STRESS; FLAXSEED
   OIL; LIPID-PEROXIDATION; RISK-FACTORS; OBESITY; GREEN; LIVER;
   INFLAMMATION
AB Introduction Metabolic syndrome comprises a collection of metabolic disorders stemming from factors like genetic predisposition, inadequate nutrition, stress, decreased physical activity, aging, and ethnicity. Although traditional pharmaceutical treatments exist for metabolic syndrome, their limited popularity is attributed to high costs and adverse effects. Consequently, natural products with fewer side effects have been explored for managing this condition. This literature review aims to explore the role of natural products including herbs, botanicals, vitamins, minerals, probiotics, and dietary supplements in managing metabolic syndrome.Methods This scoping review was conducted in five steps, involving the formulation of a research question, the retrieval and extraction of relevant studies, the selection of pertinent studies, the organization of information into tables, and the reporting of results. Data was collected from various databases including Embase, Science Direct, PubMed, Google Scholar, Scopus, and Web of Science, with a focus on studies published from 2010 to the present, available in English and with full-text accessibility.Results We identified 1,259 articles, screened their titles, abstracts, and full texts, ultimately incorporating 169 pertinent articles into this review (comprising 90 review articles, 32 trial articles, 6 in vitro articles, 38 in vivo articles, 1 experimental article and 2 observational articles). The study's outcomes revealed that natural products, encompassing plants and their derivatives, vitamins and supplements, as well as probiotics, can exert a beneficial influence on metabolic syndrome by regulating blood sugar, blood pressure, lipid profiles, obesity, and abnormal cholesterol and triglyceride levels.Conclusion The current study underscores the significance of natural products in addressing metabolic syndrome. Consequently, it is advisable to conduct further extensive research to assess the efficacy of these products, potentially integrating them into treatment regimens for individuals with metabolic syndrome.
C1 [Abdulghani, Mohammed Faris; Al-Fayyadh, Sadeq] Univ Baghdad, Nursing Coll, Baghdad, Iraq.
C3 University of Baghdad
RP Abdulghani, MF (corresponding author), Univ Baghdad, Nursing Coll, Baghdad, Iraq.
EM mohammed.abd2102p@conursing.uobaghdad.edu.iq
RI AL-Fayyadh, Sadeq/AAT-1993-2020; Abdulghani, Mohammed
   Faris/ABG-2652-2022
OI Abdulghani, Mohammed Faris/0000-0002-5158-5235
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NR 193
TC 7
Z9 7
U1 4
U2 11
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD APR 30
PY 2024
VL 15
AR 1366946
DI 10.3389/fphar.2024.1366946
PG 19
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA QL7R5
UT WOS:001221099800001
PM 38746011
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Goens, D
   Virzi, NE
   Jung, SE
   Rutledge, TR
   Zarrinpar, A
AF Goens, Donald
   Virzi, Nicole E.
   Jung, Sarah E.
   Rutledge, Thomas R.
   Zarrinpar, Amir
TI Obesity, Chronic Stress, and Stress Reduction
SO GASTROENTEROLOGY CLINICS OF NORTH AMERICA
LA English
DT Article
DE Insulin resistance; Cardiovascular disease; Metabolic syndrome;
   Nonalcoholic fatty liver disease; Caloric restriction; Mindfulness-based
   interventions; Circadian rhythms; Sleep
ID COGNITIVE-BEHAVIORAL THERAPY; FATTY LIVER-DISEASE; EATING PATTERNS;
   SLEEP DURATION; SHIFT WORK; ALCOHOL; HEALTH; RISK; METAANALYSIS;
   ASSOCIATION
C1 [Goens, Donald; Zarrinpar, Amir] Univ Calif San Diego, Div Gastroenterol, 9500 Gilman Dr, La Jolla, CA 92093 USA.
   [Virzi, Nicole E.] Univ Calif San Diego, San Diego State Univ, Dept Clin Psychol, Joint Doctoral Program, 6363 Alvarado Court, San Diego, CA 92120 USA.
   [Jung, Sarah E.; Rutledge, Thomas R.; Zarrinpar, Amir] VA San Diego Sci, 3350 La Jolla Village Dr, San Diego, CA 92161 USA.
   [Zarrinpar, Amir] Univ Calif San Diego, Div Gastroenterol, 9500 Gilman Dr, La Jolla, CA 92093 USA.
C3 University of California System; University of California San Diego;
   California State University System; San Diego State University;
   University of California System; University of California San Diego;
   University of California System; University of California San Diego
RP Zarrinpar, A (corresponding author), Univ Calif San Diego, Div Gastroenterol, 9500 Gilman Dr, La Jolla, CA 92093 USA.
EM azarrinp@ucsd.edu
RI Zarrinpar, Amir/L-4077-2019
OI Zarrinpar, Amir/0000-0001-6423-5982
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NR 66
TC 13
Z9 13
U1 2
U2 8
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0889-8553
EI 1558-1942
J9 GASTROENTEROL CLIN N
JI Gastroenterol. Clin. North Am.
PD JUN
PY 2023
VL 52
IS 2
BP 347
EP 362
DI 10.1016/j.gtc.2023.03.009
EA MAY 2023
PG 16
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA I9KP3
UT WOS:001005899300001
PM 37197878
OA Bronze, Green Accepted
DA 2025-06-11
ER

PT J
AU Happell, B
   Stanton, R
   Hoey, W
   Scott, D
AF Happell, Brenda
   Stanton, Robert
   Hoey, Wendy
   Scott, David
TI Cardiometabolic health nursing to improve health and primary care access
   in community mental health consumers: Protocol for a randomised
   controlled trial
SO INTERNATIONAL JOURNAL OF NURSING STUDIES
LA English
DT Article
DE Health care utilisation; Mental illness; Physical health; Primary health
   care; Randomised controlled trial
ID MEDICAL-CARE; METABOLIC SYNDROME; EXCESS MORTALITY; RISK-FACTORS;
   PREVALENCE; ILLNESS; AUSTRALIANS; OBESITY
AB Background: People with a serious mental illness are at significantly greater risk of poor cardiometabolic health with recent studies showing a greater than two-fold increase in the risk of obesity, infectious diseases, diabetes and cardiovascular disease. Contributing factors to this disparity include poorer health behaviours such as suboptimal physical activity, poor diet, smoking, alcohol and illicit drug misuse. In particular, the limited access to primary health care experienced by people with a serious mental illness has been highlighted. Persons with a serious mental illness are around 30% less likely than those without serious mental illness to receive health assessments, hospital admissions or procedures for cardiovascular disease and diabetes, and are less likely to undergo cancer screening or receive vaccinations. Studies show that mental health consumers may be more likely to use mental health services rather than primary care for contact with the health care system. However mental health nurses report several barriers to their capacity to provide cardiometabolic health care crucial for the treatment of people with a serious mental illness.
   Objectives: To assess the impact of a specialist Cardiometabolic Health Nurse on the physical health care of community based mental health consumers.
   Setting: Community mental health facility in a large regional centre in Central Queensland, Australia.
   Design/methods: Community based mental health consumers will be randomised to receive either usual care, or consultations with a Cardiometabolic Health Nurse. The Cardiometabolic Health Nurse will be responsible for assessing the client and coordinating cardiometabolic health care as required. Post intervention review of health records will be performed with the primary outcome measure being self-reported physical health. Secondary outcomes include the utilisation of primary care services and changes in health behaviours. We hypothesise that the Cardiometabolic Health Nurse will increase the utilisation of health care services for mental health consumers.
   Results: Data collection commenced in March 2013 and will conclude September 2013. Preliminary finding are expected in December 2013. (C) 2013 Elsevier Ltd. All rights reserved.
C1 [Happell, Brenda; Stanton, Robert; Scott, David] Cent Queensland Univ, Inst Hlth & Social Sci Res, Ctr Mental Hlth Nursing Innovat, Rockhampton, Qld 4702, Australia.
   [Scott, David] Univ Melbourne, NorthWest Acad Ctr, Melbourne, Vic 3001, Australia.
   [Hoey, Wendy] Cent Queensland Hosp & Hlth Serv, Cent Queensland Mental Hlth Alcohol & Other Drugs, Rockhampton, Qld 4700, Australia.
C3 Central Queensland University; University of Melbourne
RP Stanton, R (corresponding author), Cent Queensland Univ, Inst Hlth & Social Sci Res, Ctr Mental Hlth Nursing Innovat, Rockhampton, Qld 4702, Australia.
EM r.stanton@cqu.edu.au
RI Scott, David/AAE-5031-2021; Stanton, Rob/AAJ-5157-2020; Happell,
   Brenda/HSI-0570-2023
OI Scott, David/0000-0001-5226-1972; Happell, Brenda/0000-0002-7293-6583
FU Australian Health Services Initiative (AusHSI) [SG0005-000088]; Office
   of Health and Medical Research Nursing and Midwifery Grants;
   CQUniversity under the Research Development Initiatives Seed Grant
   Scheme
FX Professor Brenda Happell, Dr. David Scott and Wendy Hoey received
   funding from the Australian Health Services Initiative (AusHSI) - Grant
   No: SG0005-000088. Professor Brenda Happell and Dr. David Scott received
   funding from the Office of Health and Medical Research Nursing and
   Midwifery Grants. Dr. David Scott received funding from CQUniversity
   under the Research Development Initiatives Seed Grant Scheme. We also
   acknowledge the support of the Doctors and staff at CQMHS, Queensland
   Health and the participants.
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NR 28
TC 9
Z9 9
U1 0
U2 23
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0020-7489
EI 1873-491X
J9 INT J NURS STUD
JI Int. J. Nurs. Stud.
PD FEB
PY 2014
VL 51
IS 2
BP 236
EP 242
DI 10.1016/j.ijnurstu.2013.06.004
PG 7
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA AA0WA
UT WOS:000330816900009
PM 23849046
DA 2025-06-11
ER

PT J
AU House, L
   Bishop, CE
   Spankovich, C
   Su, D
   Valle, K
   Schweinfurth, J
AF House, Laura
   Bishop, Charles E.
   Spankovich, Christopher
   Su, Dan
   Valle, Karen
   Schweinfurth, John
TI Tinnitus and Its Risk Factors in African Americans: The Jackson Heart
   Study
SO LARYNGOSCOPE
LA English
DT Article; Proceedings Paper
CT 120th Annual Meeting of the Triological-Society at the Combined
   Otolaryngology Spring Meetings (COSM)
CY APR 26-30, 2017
CL San Diego, CA
SP Triol Soc
DE Otology; auditory physiology; audiology
ID PHYSICAL-ACTIVITY SURVEY; PREVALENCE; ASSOCIATION; POPULATION
AB Objectives/Hypothesis: To describe the prevalence of reported tinnitus and tinnitus handicap in the all-African American Jackson Heart Study (JHS) cohort, with assessment of the relationship to cardiometabolic risk and depression.
   Study Design: Prospective cohort study.
   Methods: Audiologic data were obtained from a sample of 1,314 participants of the JHS. Reported tinnitus was assessed dichotomously (yes/no) by interview and with the Tinnitus Handicap Inventory (THI). The statistical relationship of reported tinnitus and tinnitus handicap to various cardiometabolic risks (i.e., hypertension and waist circumference) and Center for Epidemiologic Studies Depression scale (CES-D) was assessed with logistic and gamma regression procedures.
   Results: Tinnitus was found to be a highly prevalent condition (29.5%), with an additionally high rate of individuals who report at least slight tinnitus handicap (35%). Hypertension (beta = 1.344, 95% confidence interval [CI]: 1.015-1.780, P = .039) and waist circumference (beta = 1.009, 95% CI: 1.001-1.018, P = .021) were found to have a statistically significant relationship with THI score, depending on the level of covariate adjustment. Depression, as measured by the CES-D, was found to have a statistically significant relationship with both reported tinnitus (odds ratio [OR]: 1.051, 95% CI: 1.030-1.072, P < .001) and THI score (beta = 1.029, 95% CI: 1.013-1.047, P = .001), which persisted for all levels of covariate adjustment in statistical models.
   Conclusions: Tinnitus was found to be highly prevalent in the JHS, and certain measures of cardiometabolic risk are weakly related to both reported tinnitus and level of tinnitus handicap. A consistent relationship between depression and tinnitus/level of tinnitus handicap was observed.
C1 [House, Laura; Bishop, Charles E.; Spankovich, Christopher; Schweinfurth, John] Univ Mississippi, Med Ctr, Dept Otolaryngol & Commun Sci, Jackson, MS 39216 USA.
   [Su, Dan; Valle, Karen] Univ Mississippi, Med Ctr, Dept Data Sci, Jackson, MS 39216 USA.
C3 University of Mississippi Medical Center; University of Mississippi;
   University of Mississippi Medical Center; University of Mississippi
RP Bishop, CE (corresponding author), 2500 North State St, Jackson, MS 39216 USA.
EM cebishop@umc.edu
RI Bishop, Charles/AAH-3479-2020
FU National Institute on Deafness and Other Communication Disorders
   [5-RO1-DC008371-01]
FX This work was funded by the National Institute on Deafness and Other
   Communication Disorders (5-RO1-DC008371-01).
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NR 29
TC 21
Z9 22
U1 0
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0023-852X
EI 1531-4995
J9 LARYNGOSCOPE
JI Laryngoscope
PD JUL
PY 2018
VL 128
IS 7
BP 1668
EP 1675
DI 10.1002/lary.26964
PG 8
WC Medicine, Research & Experimental; Otorhinolaryngology
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Research & Experimental Medicine; Otorhinolaryngology
GA GO4TD
UT WOS:000440007000044
PM 29193110
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Mukaetova-Ladinska, EB
   Purshouse, K
   Andrade, J
   Krishnan, M
   Jagger, C
   Kalaria, RN
AF Mukaetova-Ladinska, Elizabeta B.
   Purshouse, Karin
   Andrade, Joana
   Krishnan, Mani
   Jagger, Carol
   Kalaria, Raj N.
TI Can Healthy Lifestyle Modify Risk Factors for Dementia? Findings from a
   Pilot Community-Based Survey in Chennai (India) and Newcastle (UK)
SO NEUROEPIDEMIOLOGY
LA English
DT Article
DE Dementia; Lifestyle; Physical activity; Diet; Alcohol intake;
   Spiritual/religious beliefs; Metabolic syndrome
ID CORONARY-HEART-DISEASE; ALZHEIMERS-DISEASE; METABOLIC SYNDROME; HIGH
   PREVALENCE; DOCOSAHEXAENOIC ACID; DIETARY ANTIOXIDANTS; CARDIOVASCULAR
   RISK; MEDITERRANEAN DIET; COGNITIVE DECLINE; PHYSICAL-ACTIVITY
AB Background: Currently there are no effective treatments available for dementia. Attention has turned to defining preventive strategies and identifying modifying effects of lifestyle, including physical activity, diet, alcohol intake and smoking, in reducing cognitive decline and overt memory problems in the elderly. Methods: In this study, we addressed the modifying aspects of various components of lifestyle in two ageing samples and explored the possible effects that exercise, diet and spiritual and religious beliefs have upon physical and mental health. A total of 251 subjects (128 in Chennai, India, and 123 in Newcastle, UK) filled in a questionnaire regarding their lifestyle habits. Data were analysed with chi(2) analysis. Results: Our findings highlight that spiritual and religious beliefs promoted good physical and mental health and were negatively associated with risk factors for dementia, such as high blood pressure, high cholesterol level and diabetes. Lifelong diet and physical activity also contributed to better overall well-being in both samples. Conclusions: Our study suggests substantial lifestyle variations between two urban populations in Chennai, India, and Newcastle-upon-Tyne, UK. Further detailed work is required to identify the lifestyle components that have the greatest impact on modifying the known risk factors for dementia. Copyright (C) 2012 S. Karger AG, Basel
C1 [Mukaetova-Ladinska, Elizabeta B.; Purshouse, Karin; Andrade, Joana; Krishnan, Mani; Jagger, Carol; Kalaria, Raj N.] Newcastle Univ, Inst Ageing & Hlth, Newcastle Upon Tyne NE4 5PL, Tyne & Wear, England.
C3 Newcastle University - UK
RP Mukaetova-Ladinska, EB (corresponding author), Newcastle Univ, Inst Ageing & Hlth, Campus Ageing & Vital, Newcastle Upon Tyne NE4 5PL, Tyne & Wear, England.
EM Elizabeta.Mukaetova-Ladinska@ncl.ac.uk
RI Mukaetova-Ladinska, Elizabeta/AAG-4033-2020; Kalaria, Raj/AAX-2630-2020;
   Andrade, Joana/HTQ-2518-2023
OI Santhanakrishnan, Mani/0000-0003-1207-072X; Kalaria,
   Raj/0000-0001-7907-4923; Andrade, Joana/0000-0002-2549-0232; Purshouse,
   Karin/0000-0003-0942-6342; Jagger, Carol/0000-0002-6377-9926
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NR 67
TC 1
Z9 1
U1 0
U2 17
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0251-5350
EI 1423-0208
J9 NEUROEPIDEMIOLOGY
JI Neuroepidemiology
PY 2012
VL 39
IS 3-4
BP 163
EP 170
DI 10.1159/000338674
PG 8
WC Public, Environmental & Occupational Health; Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; Neurosciences & Neurology
GA 032KZ
UT WOS:000310718800004
PM 22948094
DA 2025-06-11
ER

PT J
AU Matthews, KA
   Räikkönen, K
   Gallo, L
   Kuller, LH
AF Matthews, Karen A.
   Raikkonen, Katri
   Gallo, Linda
   Kuller, Lewis H.
TI Association between socioeconomic status and metabolic syndrome in
   women:: Testing the reserve capacity model
SO HEALTH PSYCHOLOGY
LA English
DT Article
DE stress; resources; metabolic syndrome; longitudinal; women
ID CARDIOVASCULAR RISK-FACTORS; HEALTH; ENVIRONMENT; INEQUALITY; RESOURCES;
   CHILDHOOD; MORTALITY; EDUCATION; DISEASE; EVENTS
AB Objective: Low socioeconomic status (SES) environments may impede the development of a bank of resources, labeled reserve capacity, and may also be stressful, thereby depleting available reserves. In consequence, lower SES persons may experience more negative emotions, leading to adverse health consequences. The authors tested the reserve capacity model in relation to the metabolic syndrome. Design: There were 401 initially healthy women who followed longitudinally for 12 years. Self-reported characteristics, stressors, and cardiovascular risk factors were measured repeatedly. Structural equation modeling was used to evaluate hypothesized relationships. Main Outcome Measure: Metabolic syndrome factor. Results: Confirmatory factor analysis verified reserve capacity as the aggregate of optimism, self-esteem, and social support, and negative emotion as the aggregate of depressive symptoms, anger, and tension. Structural equation modeling showed two pathways to the metabolic syndrome factor, (X-2(59) = 111.729, p < .0001 X-2/df = 1.894; CFI = .956; RMSEA = .047): direct from low SES to the metabolic syndrome factor (B = -0.19, t = -3.24, p = .001); and indirect, from low SES to low reserve capacity to high negative emotions to the metabolic syndrome factor (B = -0.024, t = -2.05, p = .04). Conclusion: Low SES may increase risk for metabolic syndrome, in part, through reserve capacity and negative emotions.
C1 [Matthews, Karen A.] Univ Pittsburgh, Dept Psychiat, Pittsburgh, PA 15213 USA.
   [Raikkonen, Katri] Univ Helsinki, Dept Psychol, SF-00100 Helsinki, Finland.
   [Gallo, Linda] San Diego State Univ, Dept Psychol, San Diego, CA 92182 USA.
   [Kuller, Lewis H.] Univ Pittsburgh, Dept Epidemiol, Pittsburgh, PA 15213 USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE); University
   of Pittsburgh; University of Helsinki; California State University
   System; San Diego State University; Pennsylvania Commonwealth System of
   Higher Education (PCSHE); University of Pittsburgh
RP Matthews, KA (corresponding author), Univ Pittsburgh, Dept Psychiat, 3811 OHara St, Pittsburgh, PA 15213 USA.
EM matthewska@upmc.edu
OI Raikkonen, Katri/0000-0003-3124-3470; Gallo, Linda
   C./0000-0002-3678-5888
FU NIH HL [28266, 065111, 065112]
FX This research was supported by NIH HL 28266, NIH HL 065111, and NIH HL
   065112.
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NR 38
TC 87
Z9 116
U1 3
U2 21
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 0278-6133
EI 1930-7810
J9 HEALTH PSYCHOL
JI Health Psychol.
PD SEP
PY 2008
VL 27
IS 5
BP 576
EP 583
DI 10.1037/0278-6133.27.5.576
PG 8
WC Psychology, Clinical; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology
GA 350KC
UT WOS:000259350300009
PM 18823184
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Pham, AT
   van Dijk, BAC
   van der Valk, ES
   van der Vegt, B
   van Rossum, EFC
   de Bock, GH
AF Pham, An Thanh
   van Dijk, Boukje A. C.
   van der Valk, Eline S.
   van der Vegt, Bert
   van Rossum, Elisabeth F. C.
   de Bock, Geertruida H.
TI Chronic Stress Related to Cancer Incidence, including the Role of
   Metabolic Syndrome Components
SO CANCERS
LA English
DT Article
DE hair analysis; hydrocortisone; cortisone; physiological stress;
   neoplasm; metabolic syndrome
ID HAIR CORTISOL; BREAST-CANCER; LIFE EVENTS; RISK; DETERMINANTS;
   METAANALYSIS; GUIDELINES; AROMATASE; BIOMARKER
AB Simple Summary Although animal models have suggested that chronic stress can induce cancer, epidemiological findings have been inconsistent. One of the possible reasons for this inconsistency is the challenge to measure chronic stress. Recently, hair cortisol and its inactive form cortisone have shown to be a potential biomarker for chronic stress. Our study aims to investigate the relation between chronic biological stress, as measured by hair cortisol and hair cortisone, and cancer incidence, and adjust for other factors that can impact this relation such as metabolic syndrome components in a population-based cohort. While hair cortisone was related to cancer incidence when accounting for age as a confounder and gender as a moderator, we did not observe the association with hair cortisol. The involvement of metabolic syndrome components in the relation between chronic stress and cancer initiation was not found.Abstract Epidemiological results on the link between chronic stress and cancer initiation have been inconsistent. This study examined the relation between chronic biological stress, indicated as hair cortisol (HairF) and hair cortisone (HairE), and cancer incidence, adjusting for metabolic syndrome (MetS) components. We analyzed HairF and HairE samples from 6341 participants from the population-based cohort Lifelines in 2014. A linkage with the Dutch Nationwide Pathology Databank (Palga) provided the cancer incidence from 2015 to 2021. The association between dichotomized HairF and log-transformed HairE (LogHairE) and cancer incidence was estimated using Cox regression. MetS components were evaluated as confounders or moderators. Of the 2776 participants with known HairF levels and no cancer history, 238 developed cancer. The HairF level did not predict cancer incidence (HR: 0.993, 95%CI: 0.740-1.333). No confounders or moderators were identified. Among the 4699 participants with known HairE levels and no cancer history, 408 developed cancer. There was no association between LogHairE and cancer incidence (HR: 1.113, 95%CI: 0.738-1.678). When including age as a confounder and gender as a moderator, LogHairE was statistically significantly associated with cancer incidence (HR: 6.403, 95%CI: 1.110-36.92). In a population-based cohort, chronic biological stress, measured by HairE, was associated with cancer incidence, after controlling for age and gender.
C1 [Pham, An Thanh; van Dijk, Boukje A. C.; de Bock, Geertruida H.] Univ Med Ctr Groningen, Univ Groningen, Dept Epidemiol, NL-9700 RB Groningen, Netherlands.
   [Pham, An Thanh] Ton Duc Thang Univ, Fac Pharm, Ho Chi Minh City 700000, Vietnam.
   [van Dijk, Boukje A. C.] Netherlands Comprehens Canc Org IKNL, Dept Res & Dev, NL-3511 CV Utrecht, Netherlands.
   [van der Valk, Eline S.; van Rossum, Elisabeth F. C.] Erasmus MC, Dept Internal Med, Div Endocrinol, NL-3015 GD Rotterdam, Netherlands.
   [van der Vegt, Bert] Univ Groningen, Univ Med Ctr Groningen, Dept Pathol & Med Biol, NL-9700 RB Groningen, Netherlands.
C3 University of Groningen; Ton Duc Thang University; Erasmus University
   Rotterdam; Erasmus MC; University of Groningen
RP Pham, AT (corresponding author), Univ Med Ctr Groningen, Univ Groningen, Dept Epidemiol, NL-9700 RB Groningen, Netherlands.; Pham, AT (corresponding author), Ton Duc Thang Univ, Fac Pharm, Ho Chi Minh City 700000, Vietnam.
EM t.a.pham@umcg.nl; b.a.c.van.dijk@umcg.nl; e.vandervalk@erasmusmc.nl;
   b.van.der.vegt@umcg.nl; e.vanrossum@erasmusmc.nl; g.h.de.bock@umcg.nl
RI van Dijk, Boukje/I-1208-2012; Pham, An/KPB-2060-2024; van der Vegt,
   Bert/N-2085-2019; van Rossum, Elisabeth/AAP-9388-2020; de Bock,
   Geertruida H./F-6529-2014; van der Vegt, Bert/G-5887-2014
OI van Dijk, Boukje/0000-0001-5984-4716; de Bock, Geertruida
   H./0000-0003-3104-4471; van Rossum, Elisabeth/0000-0003-0120-4913; van
   der Vegt, Bert/0000-0002-2613-1506; Pham, An Thanh/0000-0001-5271-6682
FU Dutch Ministry of Health, Welfare, and Sport; Dutch Ministry of Economic
   Affairs; University Medical Center Groningen (UMCG), University
   Groningen; Northern Provinces of The Netherlands
FX The Lifelines Cohort Study initiative has been made possible by a
   subsidy from the Dutch Ministry of Health, Welfare, and Sport, the Dutch
   Ministry of Economic Affairs, the University Medical Center Groningen
   (UMCG), University Groningen, and the Northern Provinces of The
   Netherlands. The authors wish to acknowledge the services of the
   Lifelines Cohort Study, the contributing research centers delivering
   data to Lifelines, all the study participants of the Lifelines Cohort
   Study, and all the contributing researchers of this study.
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NR 73
TC 1
Z9 1
U1 0
U2 1
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6694
J9 CANCERS
JI Cancers
PD JUN
PY 2024
VL 16
IS 11
AR 2044
DI 10.3390/cancers16112044
PG 13
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA UA7M9
UT WOS:001245407600001
PM 38893162
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Heald, A
AF Heald, A.
TI Physical health in schizophrenia: a challenge for antipsychotic therapy
SO EUROPEAN PSYCHIATRY
LA English
DT Article
DE Schizophrenia; Physical health; Antipsychotic therapy; Health
   assessment; Diabetes; Cardiovascular risk
ID BODY-MASS INDEX; METABOLIC SYNDROME; HEART-DISEASE; ATYPICAL
   ANTIPSYCHOTICS; MORTALITY; RISK; CATIE; DEATH; INDIVIDUALS; ASSOCIATION
AB In the management of schizophrenia, mental health outcomes are the principal focus of treatment. The objective is to control the psychotic symptoms while minimising negative features of the illness, to achieve an overall improvement in the societal functioning of patients. Physical health is also important because if it is compromised, many of the benefits of improved mental health will be offset. Compared with the general population, schizophrenia patients are at increased risk of weight gain, abdominal obesity, diabetes, metabolic syndrome, and cardiovascular disease. These physical health problems can contribute to the decreased quality of life, lowered self-esteem and reduced life expectancy commonly reported in schizophrenia. For these reasons there is a pressing need to improve both the monitoring and the management of physical health in patients with schizophrenia as a part of their overall care. A consensus for metabolic monitoring of patients receiving treatment with antipsychotic drugs is available. However, the practicing clinician requires guidance about management of physical health in routine clinical practice. This should include recommendations for measurements that have strong predictive value about physical health risks yet are easy to make, and about the use of medications that have the least effect on physical health parameters. This article will review the gravity of the physical health risks facing schizophrenia patients.
C1 Leighton Hosp, Ward Off 7, Crewe CW1 4QJ, Cheshire, England.
RP Heald, A (corresponding author), Leighton Hosp, Ward Off 7, Middlewich Rd, Crewe CW1 4QJ, Cheshire, England.
EM adrian.heald@manchester.ac.uk
FU sanofi-aventis; Bristol-Myers Squibb
FX A. Heald: Consultant or speaker (sanofi-aventis, Eli Lilly,
   Bristol-Myers Squibb, GlaxoSmithKline and Takeda); Unrestricted research
   funding from sanofi-aventis and Bristol-Myers Squibb.
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NR 43
TC 53
Z9 53
U1 0
U2 12
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0924-9338
EI 1778-3585
J9 EUR PSYCHIAT
JI Eur. Psychiat.
PD JUN
PY 2010
VL 25
SU 2
BP S6
EP S11
DI 10.1016/S0924-9338(10)71700-4
PG 6
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 627CJ
UT WOS:000280016000003
PM 20620888
DA 2025-06-11
ER

PT J
AU Wong, EML
   Leung, DYP
   Wang, Q
   Leung, AYM
AF Wong, Eliza Mi-Ling
   Leung, Doris Y. P.
   Wang, Qun
   Leung, Angela Y. M.
TI A nurse-led lifestyle intervention using mobile application versus
   booklet for adults with metabolic syndrome-Protocol for a randomized
   controlled trial
SO JOURNAL OF ADVANCED NURSING
LA English
DT Article
DE adults; booklet; effectiveness; lifestyle intervention; metabolic
   syndrome; mobile application; nurses; nursing; randomized controlled
   trial
ID CARDIOVASCULAR RISK; EXERCISE; PROGRAM; DEPRESSION; EFFICACY; OUTCOMES
AB Aims To compare the effect of a lifestyle intervention programme using mobile application versus booklet for adults with metabolic syndrome (MetS) living in the community. Design A multisite randomized controlled trial with three parallel arms, namely metabolic syndrome app group, booklet group, and control group. Methods The research study has been supported by the Health and Medical Research fund in Hong Kong in 2019. The protocol was approved by the study university and the selected community centres. Three hundred and sixty subjects will be recruited from community centres and randomized into either one arm. Inclusion criteria are those adult with MetS, able to use a smart phone. All participants received a 30-min health educational session. App group participants will receive a mobile application while booklet group participants will receive a specific booklet of MetS care and the control group receive a placebo booklet only. The primary outcomes comprises of body weight. The secondary outcomes include total physical exercise, cardiometablolic risk factors, cardiovascular endurance, self-efficacy for exercise, and stress level. Data will be collected at baseline, weeks 4, 12, and 24. SPSS and generalized estimating equations model will be employed for data analysis. Discussion Metabolic syndrome is a common health problem associated with the heightened risk of cardiovascular disease and the risks are potentially amenable to lifestyle intervention. The results will compare the relative effectiveness of a lifestyle intervention using an app versus a booklet on physical and psychological outcomes for adults with MetS. Impact What problem will the study address? The results will inform the healthcare professional and nurses about the effective way for health promotion, to enhance patient's lifestyle modification and exercise sustainability that will be beneficial to the clients' health.
C1 [Wong, Eliza Mi-Ling; Leung, Doris Y. P.; Leung, Angela Y. M.] Hong Kong Polytech Univ, Sch Nursing, Hong Kong, Peoples R China.
   [Wang, Qun] Shenzhen Univ, Sch Nursing, Shenzhen, Peoples R China.
C3 Hong Kong Polytechnic University; Shenzhen University
RP Wong, EML (corresponding author), Hong Kong Polytech Univ, Sch Nursing, Kowloon, GH 521 Hung Hom, Hong Kong, Peoples R China.
EM eliza.wong@polyu.edu.hk
RI WANG, Qun/AAP-9908-2021; Wong, Eliza/AAH-6193-2020; Leung,
   Angela/X-4415-2019; Leung, Doris/T-6985-2019; Leung, Angela
   YM/C-4768-2009; Leung, Doris Y.P./K-4878-2014
OI Wang, Qun/0000-0001-7594-8312; Leung, Angela YM/0000-0002-9836-1925;
   Wong, Eliza ML/0000-0003-0698-9000; Leung, Doris
   Y.P./0000-0003-0138-8839
FU Health Medical Research Fund [10110301]; Food and Health Bureau, Hong
   Kong SAR
FX This research is supported by the Health Medical Research Fund (no.
   10110301), Food and Health Bureau, Hong Kong SAR.
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U1 0
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PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0309-2402
EI 1365-2648
J9 J ADV NURS
JI J. Adv. Nurs.
PD JAN
PY 2020
VL 76
IS 1
BP 364
EP 372
DI 10.1111/jan.14241
EA NOV 2019
PG 9
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA KW7QX
UT WOS:000497225600001
PM 31642088
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Chen, X
   Yan, XR
   Liu, J
   Zhang, LP
AF Chen, Xun
   Yan, Xiao-Ru
   Liu, Jing
   Zhang, Li-Ping
TI Chaiqi decoction ameliorates vascular endothelial injury in metabolic
   syndrome by upregulating autophagy
SO AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
LA English
DT Article
DE Metabolic syndrome; Chaiqi decoction; vascular endothelial injury;
   autophagy
ID IMPROVES CARDIAC-FUNCTION; PALMITATE UNCOUPLE AMPK; NITRIC-OXIDE
   SYNTHASE; HIGH-FAT; MAMMALIAN TARGET; OXIDATIVE-STRESS; RAT MODEL;
   DIABETIC MICE; RAPAMYCIN; DYSFUNCTION
AB Objective: The present study aimed to investigate the protective effect of the Chaiqi decoction on vascular endothelial injury in metabolic syndrome and to determine whether the underlying mechanism was associated with autophagy. Methods: Chaiqi formula granules were administered to a rat model of metabolic syndrome established by feeding with a high-salt-sugar-fat diet (HSSFD). The drug-containing serum was used in a hyperglycemia cell model established using HUVECs cultured with palmitic acid PA. The influence of the Chaiqi decoction on metabolic syndrome-related vascular endothelial injury and autophagy was investigated. Autophagy flux was assessed in vitro by transfecting cells with GFP-mRFP-LC3 adenoviruses or incubating with DALGreen and DAPRed. Results: The metabolic syndrome model rats displayed adiposity, hyperglycemia, dyslipidemia, hypertension, thickened intima, deposition of various forms of collagen and lipid droplets, downregulated levels of phosphorylated endothelial nitric oxide synthase and nitric oxide, upregulated expression of endothelin 1, and dysfunctional autophagy. All these abnormalities were ameliorated by administration of the Chaiqi decoction to the metabolic syndrome rats. Furthermore, the Chaiqi-containing serum could upregulate autophagy similarly to rapamycin, in a time-dependent manner. Conclusion: The Chaiqi decoction could ameliorate vascular endothelial injury by improving autophagy in metabolic syndrome.
C1 [Chen, Xun] China Acad Chinese Med Sci, Xiyuan Hosp, Beijing, Peoples R China.
   [Chen, Xun; Liu, Jing; Zhang, Li-Ping] Beijing Univ Chinese Med, 11 Bei San Huan Dong Lu, Beijing 100029, Peoples R China.
   [Yan, Xiao-Ru] China Acad Chinese Med Sci, Guanganmen Hosp, Beijing, Peoples R China.
   [Liu, Jing; Zhang, Li-Ping] Beijing Univ Chinese Med, Dongfang Hosp, Beijing 100078, Peoples R China.
C3 China Academy of Chinese Medical Sciences; Xiyuan Hospital, CACMS;
   Beijing University of Chinese Medicine; China Academy of Chinese Medical
   Sciences; Guang'anmen Hospital, CACMS; Beijing University of Chinese
   Medicine
RP Zhang, LP (corresponding author), Beijing Univ Chinese Med, 11 Bei San Huan Dong Lu, Beijing 100029, Peoples R China.; Liu, J (corresponding author), Beijing Univ Chinese Med, Dongfang Hosp, Beijing 100078, Peoples R China.
EM liu-jing20120114@163.com; lpzhang2005@126.com
FU Beijing University of Chinese Medicine [2019-JYB-JS-114]
FX The study was supported by the self-selected topic of the Beijing
   University of Chinese Medicine (Grant no. 2019-JYB-JS-114).
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NR 85
TC 5
Z9 5
U1 0
U2 5
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 1943-8141
J9 AM J TRANSL RES
JI Am. J. Transl. Res.
PY 2020
VL 12
IS 9
BP 4902
EP 4922
PG 21
WC Oncology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Research & Experimental Medicine
GA NZ1BG
UT WOS:000576826300005
PM 33042397
DA 2025-06-11
ER

PT J
AU Sodhi, K
   Maxwell, K
   Yan, YL
   Liu, J
   Chaudhry, MA
   Getty, M
   Xie, ZJ
   Abraham, NG
   Shapiro, JI
AF Sodhi, Komal
   Maxwell, Kyle
   Yan, Yanling
   Liu, Jiang
   Chaudhry, Muhammad A.
   Getty, Morghan
   Xie, Zijian
   Abraham, Nader G.
   Shapiro, Joseph I.
TI RETRACTED: pNaKtide inhibits Na/K-ATPase reactive oxygen species
   amplification and attenuates adipogenesis (Retracted article. See vol.
   8, 2022)
SO SCIENCE ADVANCES
LA English
DT Article; Retracted Publication
ID IMPROVES INSULIN SENSITIVITY; INCREASES ADIPONECTIN LEVELS; OXIDATIVE
   STRESS; ADIPOSE-TISSUE; ADIPOCYTE DYSFUNCTION; VASCULAR DYSFUNCTION;
   METABOLIC SYNDROME; NA+/K+-ATPASE; OBESITY; MICE
AB Obesity has become a worldwide epidemic and is a major risk factor for metabolic syndrome. Oxidative stress is known to play a role in the generation and maintenance of an obesity phenotype in both isolated adipocytes and intact animals. Because we had identified that the Na/K-ATPase can amplify oxidant signaling, we speculated that a peptide designed to inhibit this pathway, pNaKtide, might ameliorate an obesity phenotype. To test this hypothesis, we first performed studies in isolated murine preadipocytes (3T3L1 cells) and found that pNaKtide attenuated oxidant stress and lipid accumulation in a dose-dependent manner. Complementary experiments in C57Bl6 mice fed a high-fat diet corroborated our in vitro observations. Administration of pNaKtide in these mice reduced body weight gain, restored systemic redox and inflammatory milieu, and, crucially, improved insulin sensitivity. Thus, we propose that inhibition of Na/K-ATPase amplification of oxidative stress may ultimately be a novel way to combat obesity, insulin resistance, and metabolic syndrome.
C1 [Sodhi, Komal; Maxwell, Kyle; Yan, Yanling; Liu, Jiang; Chaudhry, Muhammad A.; Getty, Morghan; Xie, Zijian; Abraham, Nader G.; Shapiro, Joseph I.] Marshall Univ, Joan C Edwards Sch Med, Dept Med, Huntington, WV 25701 USA.
   [Sodhi, Komal; Maxwell, Kyle; Yan, Yanling; Liu, Jiang; Chaudhry, Muhammad A.; Getty, Morghan; Xie, Zijian; Abraham, Nader G.; Shapiro, Joseph I.] Marshall Univ, Joan C Edwards Sch Med, Dept Pharmacol, Huntington, WV 25701 USA.
   [Sodhi, Komal; Maxwell, Kyle; Yan, Yanling; Liu, Jiang; Chaudhry, Muhammad A.; Getty, Morghan; Xie, Zijian; Abraham, Nader G.; Shapiro, Joseph I.] Marshall Univ, Joan C Edwards Sch Med, Dept Surg, Huntington, WV 25701 USA.
   [Abraham, Nader G.] New York Med Coll, Dept Med, Valhalla, NY 10595 USA.
C3 Marshall University; Marshall University; Marshall University; New York
   Medical College
RP Shapiro, JI (corresponding author), Marshall Univ, Joan C Edwards Sch Med, Dept Med, Huntington, WV 25701 USA.
EM shapiroj@marshall.edu
RI Yan, Yanling/AAX-1691-2020
OI Liu, Jiang/0000-0002-0654-707X; Chaudhry, Muhammad/0000-0002-6744-8841
FU NIH [HL109015, HL071556, HL105649, HL55601, HL34300]; Brickstreet
   Foundation; Huntington Foundation Inc.
FX This work was supported by NIH grants HL109015 (to J.I.S. and Z.X.),
   HL071556 and HL105649 (to J.I.S.), and HL55601 and HL34300 (to N.G.A.);
   the Brickstreet Foundation (to J.I.S. and N.G.A.); and the Huntington
   Foundation Inc.
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NR 40
TC 70
Z9 82
U1 0
U2 10
PU AMER ASSOC ADVANCEMENT SCIENCE
PI WASHINGTON
PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA
SN 2375-2548
J9 SCI ADV
JI Sci. Adv.
PD OCT
PY 2015
VL 1
IS 9
AR e1500781
DI 10.1126/sciadv.1500781
PG 9
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA V0V5R
UT WOS:000216598200030
PM 26601314
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Rosen, SD
   Paulesu, E
   Wise, RLS
   Camici, PG
AF Rosen, SD
   Paulesu, E
   Wise, RLS
   Camici, PG
TI Central neural contribution to the perception of chest pain in cardiac
   syndrome X
SO HEART
LA English
DT Article
ID NORMAL CORONARY-ARTERIES; MYOCARDIAL-ISCHEMIA; ANGINA-PECTORIS; STRESS;
   METABOLISM; MECHANISMS; ACTIVATION; ABSENCE; HUMANS
AB Objective: To investigate the central neural contribution to chest pain perception in cardiac syndrome X (angina-like pain, ECG changes during stress, angiographically normal coronary arteriogram).
   Subjects: Eight syndrome X patients and eight healthy volunteers.
   Methods: Dobutamine stress using echocordiography to assess myocardial function, and positron emission tomography to measure changes in regional cerebral blood flow, as an index of neuronal activity.
   Results: During similar doses of dobutamine, syndrome X patients and controls showed comparable regional cerebral blood flow changes in the hypothalamus, thalami, right orbito-frontal cortex, and anterior temporal poles, associated with the sensation of a fast or powerful heart beat. In patients, but not controls, the stress also generated severe chest pain associated with increased activity in the right anterior insula/frontal operculum junction. There were ischaemia-like ECG changes in the syndrome X patients, but no left ventricular dysfunction on echocardiography. Activation of the right insula during chest pain clearly distinguished the syndrome X patients from a group of patients with known coronary disease.
   Conclusions: Chest pain and ECG changes were not accompanied by demonstrable myocardial dysfunction in syndrome X patients, but altered central neural handling of afferent signals may contribute to the abnormal pain perception in these patients.
C1 Univ London Imperial Coll Sci Technol & Med, MRC, Ctr Clin Sci, Fac Med, London, England.
   Univ Milano Bicocca, IRCCS H San Raffaele, CNR, INB,Dept Psychol, I-20126 Milan, Italy.
C3 Imperial College London; Vita-Salute San Raffaele University; IRCCS
   Ospedale San Raffaele; Consiglio Nazionale delle Ricerche (CNR);
   University of Milano-Bicocca
RP Rosen, SD (corresponding author), Hammersmith Hosp, MRC, Cyclotron Unit, Du Cane Rd, London W12 0HS, England.
EM stuart.rosen@ic.ac.uk
RI Camici, Paolo/AAN-1959-2020; Rosen, Stuart/AAE-4649-2020; PAULESU,
   ERALDO/C-2737-2017
OI PAULESU, ERALDO/0000-0002-9224-754X
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NR 30
TC 86
Z9 92
U1 0
U2 0
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 1355-6037
EI 1468-201X
J9 HEART
JI Heart
PD JUN
PY 2002
VL 87
IS 6
BP 513
EP 519
DI 10.1136/heart.87.6.513
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 554ZK
UT WOS:000175767100007
PM 12010930
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Xu, DF
   Pan, D
   Liu, HC
   Yang, C
   Yang, X
   Wang, X
   Liu, F
   Feng, MY
   Wu, QH
   Shen, YM
   Yang, LG
   Wang, SK
   Sun, GJ
AF Xu, Dengfeng
   Pan, Da
   Liu, Hechun
   Yang, Chao
   Yang, Xian
   Wang, Xin
   Liu, Feng
   Feng, Meiyuan
   Wu, Qiuhua
   Shen, Yumei
   Yang, Ligang
   Wang, Shaokang
   Sun, Guiju
TI Improvement in cardiometabolic risk markers following an oatmeal diet is
   associated with gut microbiota in mildly hypercholesterolemic
   individuals
SO FOOD RESEARCH INTERNATIONAL
LA English
DT Article
DE Total cholesterol; Cardiovascular diseases; Oatmeal; Gut microbiota;
   Short-chain fatty acids
ID CHAIN FATTY-ACIDS; OAT BETA-GLUCAN; CARDIOVASCULAR-DISEASE; OXIDATIVE
   STRESS; LDL-CHOLESTEROL; WHOLE GRAINS; INFLAMMATION; CONSUMPTION; FIBER;
   METAANALYSIS
AB Cardiovascular diseases have been the leading cause of death worldwide for decades. Some animal studies have indicated that oatmeal could improve gut microbiota and cardiometabolic risk markers. However, vivo evidence remained limited, especially in individuals with mild hypercholesterolemia. Our purpose was to explore the beneficial effects of oatmeal on serum lipids, oxidative stress and inflammation levels, and their correlations with gut microbiota and short-chain fatty acids (SCFAs) in mildly hypercholesterolemic individuals. The study was a randomized, single-blind, placebo-controlled trial. A total of 62 qualified participants were randomly divided into control group and oatmeal group with a 45-day follow-up. 16S rDNA and Gas-Chromatography Mass Spectrometry were employed respectively to measure the changes in gut microbiota and SCFAs at the start and the end of the intervention period. Cardiometabolic risk markers were assayed via commercial kits. The results suggested that oatmeal could significantly decrease serum total cholesterol (TC) (-8.59 %, p = 0.013), low density lipoprotein cholesterol (LDL-c) (-12.97 %, p = 0.004) and non-high density lipoprotein cholesterol (non-HDL-c) (-10.98 %, p = 0.040) level. In terms of oxidative stress, oatmeal significantly increased serum total antioxidant capacity (T-AOC) (21.98 %, p < 0.001), superoxide dismutase (SOD) (15.53 %, p = 0.044) levels and decreased concentration of malondialdehyde (MDA) (-19.11 %, p = 0.033) compared with control group. While no significant effect was observed in inflammatory factors. SCFAs results indicated that oatmeal could signifi-cantly increase serum acetic acid, propionic acid and valeric acid. The results of 16S rDNA showed that there was a significant difference in the alteration of beta-diversity between groups throughout the whole trial. Oatmeal resulted in the increases of Akkermansia, Dialister, Faecalibacterium, Barnesiella, Agathobacter, Lactobacillus and the decrease of Ruminococcaceae-MK4A214-group. Correlation analysis further suggested that the lipids regulation effect of oatmeal may be mainly mediated by Lactobacillus and Dialister, as well as some SCFAs (e.g., acetic acid and propionic acid), while Barnesiella and Akkermansia may play a crucial role in ameliorating oxidative stress level. In conclusion, despite of its small sample size, the present study is the first clinical trial performed in Chinese individuals with mild hypercholesterolemia to explore the effects of oatmeal on serum lipids, oxidative stress, inflammation levels, and gut microbiota. The results demonstrated that oatmeal could induce some beneficial changes in serum lipids, oxidative stress, gut microbiota composition and SCFAs. Correlation analysis further extended our understanding of the role of gut microbiota and SCFAs in improving cardiometabolic risk markers.
C1 [Xu, Dengfeng; Pan, Da; Liu, Hechun; Yang, Chao; Yang, Xian; Yang, Ligang; Wang, Shaokang; Sun, Guiju] Southeast Univ, Sch Publ Hlth, Key Lab Environm Med & Engn Minist Educ, Nanjing 210009, Peoples R China.
   [Xu, Dengfeng; Pan, Da; Liu, Hechun; Yang, Chao; Yang, Xian; Yang, Ligang; Wang, Shaokang; Sun, Guiju] Southeast Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Nanjing 210009, Peoples R China.
   [Wang, Xin] Chinese Nutr Ctr Educ, Beijing 100101, Peoples R China.
   [Liu, Feng; Feng, Meiyuan] PepsiCo Inc, Dept R&D Life Sci, Shanghai, Peoples R China.
   [Wu, Qiuhua; Shen, Yumei] Nanjing Yijia Hlth Care Management Co Ltd, Nanjing 210017, Peoples R China.
C3 Southeast University - China; Southeast University - China
RP Sun, GJ (corresponding author), Southeast Univ, Sch Publ Hlth, Key Lab Environm Med & Engn Minist Educ, Nanjing 210009, Peoples R China.; Sun, GJ (corresponding author), Southeast Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Nanjing 210009, Peoples R China.
RI Pan, Da/JCD-7757-2023
OI LIU, HECHUN/0000-0002-9274-890X
FU National Natural Science Foundation of China [82173509]; Postgraduate
   Research & Practice Innovation Program of Jiangsu Province [KYCX21-0164]
FX Funding statement The project was funded by National Natural Science
   Foundation of China (Grant No. 82173509) and Postgraduate Research &
   Practice Innovation Program of Jiangsu Province (Grant No. KYCX21-0164)
   .
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NR 70
TC 13
Z9 13
U1 8
U2 69
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0963-9969
EI 1873-7145
J9 FOOD RES INT
JI Food Res. Int.
PD OCT
PY 2022
VL 160
AR 111701
DI 10.1016/j.foodres.2022.111701
EA JUL 2022
PG 15
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA 4X7PP
UT WOS:000861029900004
PM 36076452
DA 2025-06-11
ER

PT J
AU Martinelli, I
   Tomassoni, D
   Moruzzi, M
   Traini, E
   Amenta, F
   Tayebati, SK
AF Martinelli, Ilenia
   Tomassoni, Daniele
   Moruzzi, Michele
   Traini, Enea
   Amenta, Francesco
   Tayebati, Seyed Khosrow
TI Obesity and Metabolic Syndrome Affect the Cholinergic Transmission and
   Cognitive Functions
SO CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
LA English
DT Review
DE Brain; cholinergic system; cognitive decline; inflammation; metabolic
   syndrome; obesity
ID BODY-MASS INDEX; HIGH-FAT DIET; VESICULAR ACETYLCHOLINE TRANSPORTER;
   ALZHEIMERS-DISEASE; INSULIN-RESISTANCE; OXIDATIVE STRESS; MITOCHONDRIAL
   DYSFUNCTION; CALORIE RESTRICTION; NATIONAL INSTITUTE; INCIDENT DEMENTIA
AB Background: Worldwide, at least 2.8 million people die each year as a result of being overweight or obese. Obesity leads to metabolic syndrome, a pathological condition characterized by adverse metabolic effects on blood pressure, cholesterol, triglycerides and insulin resistance. Population-based investigations have suggested that obesity and metabolic syndrome may be associated with poorer cognitive performance.
   Method: A structured search of bibliographic source (PubMed) was undertaken. The following terms "inflammation and obesity and brain", "cholinergic system and obesity", "cholinergic system and metabolic syndrome", "Cognitive impairment and obesity" and "metabolic syndrome and brain" were used as search strings.
   Results: Over 200 papers, mainly published in the past 10 years were analysed. The major results regarded keyword "metabolic syndrome and brain" followed by, "Cognitive impairment and obesity", "inflammation and obesity and brain", "cholinergic system and obesity" and "cholinergic system and metabolic syndrome". Most papers were pre-clinical but, in general, they were inhomogeneous. Therefore, the results were cited according their contribution to clarify the molecular involvement of obesity and/or metabolic syndrome in cholinergic impairment.
   Conclusion: This review focuses on the correlation between brain cholinergic system alterations and high-fat diet, describing the involvement of cholinergic system in inflammatory processes related to metabolic syndrome and obesity, which may lead to cognitive decline. Metabolic syndrome has been suggested as a risk factor for cerebrovascular diseases and has been associated with cognitive impairment in different functional brain domains. Preclinical and clinical studies have identified the cholinergic system as a specific target of metabolic syndrome and obesity. The modifications of cholinergic neurotransmission and its involvement in neuro-inflammation may be related to cognitive impairment that affects obese patients.
C1 [Martinelli, Ilenia; Moruzzi, Michele; Traini, Enea; Amenta, Francesco; Tayebati, Seyed Khosrow] Univ Camerino, Sch Med Sci & Hlth Prod, Via Madonna della Carceri 9, I-62032 Camerino, MC, Italy.
   [Tomassoni, Daniele] Univ Camerino, Sch Biosci & Vet Med, Camerino, Italy.
C3 University of Camerino; University of Camerino
RP Tayebati, SK (corresponding author), Univ Camerino, Sch Med Sci & Hlth Prod, Via Madonna della Carceri 9, I-62032 Camerino, MC, Italy.
EM khosrow.tayebati@unicam.it
RI Tayebati, Seyed/AGK-8739-2022
OI MARTINELLI, ILENIA/0000-0002-7702-7784; Traini, Enea/0000-0001-5275-4099
FU University of Camerino, University Research Projects - FAR."Fondo di
   Ateneo per la ricerca"
FX The present study was supported by the grant of the University of
   Camerino, University Research Projects - FAR. 2014-2015 "Fondo di Ateneo
   per la ricerca".
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NR 170
TC 21
Z9 21
U1 0
U2 14
PU BENTHAM SCIENCE PUBL
PI BUSUM
PA PO BOX 294, BUSUM, 1400 AG, NETHERLANDS
SN 1871-5273
EI 1996-3181
J9 CNS NEUROL DISORD-DR
JI CNS Neurol. Disord.-Drug Targets
PY 2017
VL 16
IS 6
BP 664
EP 676
DI 10.2174/1871527316666170428123853
PG 13
WC Neurosciences; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Pharmacology & Pharmacy
GA FE8JR
UT WOS:000408451900005
PM 28462694
DA 2025-06-11
ER

PT J
AU Russell, G
   Lightman, S
AF Russell, Georgina
   Lightman, Stafford
TI The human stress response
SO NATURE REVIEWS ENDOCRINOLOGY
LA English
DT Review
ID SUBCUTANEOUS HYDROCORTISONE INFUSION; GLUCOCORTICOID-RECEPTOR FUNCTION;
   CORTICOSTEROID-BINDING GLOBULIN; FACTOR-KAPPA-B; ADDISONS-DISEASE;
   SUPRACHIASMATIC NUCLEUS; ADRENAL INSUFFICIENCY; CIRCADIAN CLOCK;
   11-BETA-HYDROXYSTEROID DEHYDROGENASES; NORWEGIAN PATIENTS
AB The human stress response has evolved to maintain homeostasis under conditions of real or perceived stress. This objective is achieved through autoregulatory neural and hormonal systems in close association with central and peripheral clocks. The hypothalamic-pituitary-adrenal axis is a key regulatory pathway in the maintenance of these homeostatic processes. The end product of this pathway- cortisol-is secreted in a pulsatile pattern, with changes in pulse amplitude creating a circadian pattern. During acute stress, cortisol levels rise and pulsatility is maintained. Although the initial rise in cortisol follows a large surge in adrenocorticotropic hormone levels, if long-term inflammatory stress occurs, adrenocorticotropic hormone levels return to near basal levels while cortisol levels remain raised as a result of increased adrenal sensitivity. In chronic stress, hypothalamic activation of the pituitary changes from corticotropin-releasing hormone-dominant to arginine vasopressin-dominant, and cortisol levels remain raised due at least in part to decreased cortisol metabolism. Acute elevations in cortisol levels are beneficial to promoting survival of the fittest as part of the fight-or-flight response. However, chronic exposure to stress results in reversal of the beneficial effects, with long-term cortisol exposure becoming maladaptive, which can lead to a broad range of problems including the metabolic syndrome, obesity, cancer, mental health disorders, cardiovascular disease and increased susceptibility to infections. Neuroimmunoendocrine modulation in disease states and glucocorticoid-based therapeutics are also discussed.
C1 [Russell, Georgina; Lightman, Stafford] Univ Bristol, Translat Hlth Sci, Bristol Med Sch, Dorothy Hodgkin Bldg, Bristol, Avon, England.
C3 University of Bristol
RP Russell, G; Lightman, S (corresponding author), Univ Bristol, Translat Hlth Sci, Bristol Med Sch, Dorothy Hodgkin Bldg, Bristol, Avon, England.
EM Georgina.russell@bristol.ac.uk; Stafford.Lightman@bristol.ac.uk
RI Russell, Georgina/JLM-0320-2023; Lightman, Stafford/G-2107-2011
OI russell, georgina/0000-0002-1299-4116; Lightman,
   Stafford/0000-0002-8546-9646
FU EPSRC [EP/N014391/1] Funding Source: UKRI; MRC [MR/J012548/1] Funding
   Source: UKRI
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NR 147
TC 554
Z9 621
U1 24
U2 310
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 1759-5029
EI 1759-5037
J9 NAT REV ENDOCRINOL
JI Nat. Rev. Endocrinol.
PD SEP
PY 2019
VL 15
IS 9
BP 525
EP 534
DI 10.1038/s41574-019-0228-0
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism
GA IQ0CW
UT WOS:000480419200009
PM 31249398
OA Green Submitted
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Liu, J
   Guo, M
   Zhang, D
   Cheng, SY
   Liu, ML
   Ding, J
   Scherer, PE
   Liu, F
   Lu, XY
AF Liu, Jing
   Guo, Ming
   Zhang, Di
   Cheng, Shao-Ying
   Liu, Meilian
   Ding, Jun
   Scherer, Philipp E.
   Liu, Feng
   Lu, Xin-Yun
TI Adiponectin is critical in determining susceptibility to depressive
   behaviors and has antidepressant-like activity
SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF
   AMERICA
LA English
DT Article
DE adipose tissue; adipokines; tail suspension test; forced swim test;
   dexamethasome suppression test
ID GLYCOGEN-SYNTHASE KINASE-3; TUMOR-NECROSIS-FACTOR; HUMAN
   CEREBROSPINAL-FLUID; ACTIVATED PROTEIN-KINASE; TYPE-2 DIABETIC-PATIENTS;
   INSULIN SENSITIVITY; METABOLIC SYNDROME; MAJOR DEPRESSION; HIPPOCAMPAL
   NEUROGENESIS; COMPLEX DISTRIBUTION
AB Depression is a debilitating mental illness and is often comorbid with metabolic disorders such as type 2 diabetes. Adiponectin is an adipocyte-derived hormone with antidiabetic and insulin-sensitizing properties. Here we show that adiponectin levels in plasma are reduced in a chronic social-defeat stress model of depression, which correlates with decreased social interaction time. A reduction in adiponectin levels caused by haploinsufficiency results in increased susceptibility to social aversion, "anhedonia," and learned helplessness and causes impaired glucocorticoid-mediated negative feedback on the hypothalamic-pituitary-adrenal (HPA) axis. Intracerebroventricular (i.c.v.) injection of an adiponectin neutralizing antibody precipitates stress-induced depressive-like behavior. Conversely, i.c.v. administration of exogenous adiponectin produces antidepressant-like behavioral effects in normal-weight mice and in diet-induced obese diabetic mice. Taken together, these results suggest a critical role of adiponectin in depressive-like behaviors and point to a potential innovative therapeutic approach for depressive disorders.
C1 [Liu, Jing; Guo, Ming; Zhang, Di; Cheng, Shao-Ying; Liu, Meilian; Ding, Jun; Liu, Feng; Lu, Xin-Yun] Univ Texas Hlth Sci Ctr San Antonio, Dept Pharmacol, San Antonio, TX 78229 USA.
   [Lu, Xin-Yun] Univ Texas Hlth Sci Ctr San Antonio, Dept Psychiat, San Antonio, TX 78229 USA.
   [Scherer, Philipp E.] Univ Texas SW Med Ctr Dallas, Dept Internal Med, Touchstone Diabet Ctr, Dallas, TX 75390 USA.
C3 University of Texas System; University of Texas Health Science Center at
   San Antonio; University of Texas System; University of Texas Health
   Science Center at San Antonio; University of Texas System; University of
   Texas Southwestern Medical Center Dallas
RP Lu, XY (corresponding author), Univ Texas Hlth Sci Ctr San Antonio, Dept Pharmacol, San Antonio, TX 78229 USA.
EM lux3@uthscsa.edu
RI Zhang, Di/KIK-1254-2024; Lu, Xin-Yun/M-8657-2016; Liu,
   Feng/CAG-8962-2022; Scherer, Philipp/K-7819-2012; Guo,
   Ming/JZT-6505-2024
OI Guo, Ming/0000-0002-3698-5580
FU National Alliance for Research on Schizophrenia and Depression
   Independent Investigator Award; National Institutes of Health [MH096251,
   MH076929];  [DK76902];  [DK55758]
FX The authors thank Dr. Alan Frazer for critical reading of an early
   version of the manuscript. This work was supported by a National
   Alliance for Research on Schizophrenia and Depression Independent
   Investigator Award (to X.-Y.L.) and Grants MH096251 and MH076929 from
   the National Institutes of Health (to X.-Y.L.), DK76902 (to FL), and
   DK55758 (to P.E.S.).
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NR 60
TC 146
Z9 155
U1 0
U2 18
PU NATL ACAD SCIENCES
PI WASHINGTON
PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA
SN 0027-8424
J9 P NATL ACAD SCI USA
JI Proc. Natl. Acad. Sci. U. S. A.
PD JUL 24
PY 2012
VL 109
IS 30
BP 12248
EP 12253
DI 10.1073/pnas.1202835109
PG 6
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 981TD
UT WOS:000306992700074
PM 22778410
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Guarner, V
   Rubio-Ruiz, ME
AF Guarner, Veronica
   Esther Rubio-Ruiz, Maria
TI Aging, Metabolic Syndrome and the Heart
SO AGING AND DISEASE
LA English
DT Review
DE Aging; Heart; Metabolic Syndrome; oxidative stress; cardiovascular
   disease
ID NITRIC-OXIDE SYNTHASE; INSULIN-RESISTANCE; MYOCARDIAL-CONTRACTILITY;
   OXIDATIVE STRESS; INFLAMMATION; RISK; EXPRESSION; LONGEVITY; HEALTH;
   HYPERINSULINEMIA
AB Aging is accelerated when metabolic and cardiovascular diseases (CVD) are present and the risk of these diseases increases with age. Many predisposing conditions which increase in prevalence during aging, such as obesity, insulin resistance, inflammation, changes in the activity of the hypothalamus-hypophysis suprarenal axis, stress and hypertension also contribute to increase prevalence of metabolic syndrome (MS) and CVD and will be discussed in this paper. Aging and MS are frequently accompanied by several pathological conditions and some associated phenomena such as increased lipoperoxidation, generation of free radicals, increased peroxidation of nitric oxide (NO) to its toxic species, and others, resulting from oxidative stress which significantly alter the incidence of CVD. The better knowledge of mechanisms linking MS to increased CVD prevalence has led to new predictive measures and to the study of different possible new therapeutic strategies in elderly patients and patients with MS. Preventing and treating MS and CVD would be useful in promoting normal aging.
C1 [Guarner, Veronica; Esther Rubio-Ruiz, Maria] Inst Nacl Cardiol Ignacio Chavez, Dept Fisiol, Tlalpan Mexico 14080, DF, Mexico.
C3 National Institute of Cardiology - Mexico
RP Guarner, V (corresponding author), Inst Nacl Cardiol Ignacio Chavez, Dept Fisiol, Juan Badiano 1, Tlalpan Mexico 14080, DF, Mexico.
EM gualanv@yahoo.com
RI Guarner-Lans, Verónica/AFW-3723-2022
OI Rubio-Ruiz, Maria Esther/0000-0002-8844-2078; Guarner-Lans,
   Veronica/0000-0002-2655-7590
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NR 78
TC 65
Z9 79
U1 0
U2 5
PU INT SOC AGING & DISEASE
PI FORT WORTH
PA EDITORIAL OFF, 3400 CAMP BOWIE BLVD, FORT WORTH, TX 76106 USA
SN 2152-5250
J9 AGING DIS
JI Aging Dis.
PD JUN
PY 2012
VL 3
IS 3
BP 269
EP 279
PG 11
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA V32KV
UT WOS:000208951000005
PM 22724085
DA 2025-06-11
ER

PT J
AU Hopps, E
   Noto, D
   Caimi, G
   Averna, MR
AF Hopps, E.
   Noto, D.
   Caimi, G.
   Averna, M. R.
TI A novel component of the metabolic syndrome: The oxidative stress
SO NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
LA English
DT Review
DE Metabolic syndrome; Cardiovascular risk; Oxidative stress
ID IMPROVES ENDOTHELIAL FUNCTION; VISCERAL FAT ACCUMULATION; PROTEIN
   CARBONYLATION; ANTIOXIDANT STATUS; OBESE ADULTS; INFLAMMATION;
   HYPERLIPIDEMIA; ASSOCIATION; DYSFUNCTION; ACTIVATION
AB The metabolic syndrome (MS) represents a cluster of cardiovascular (CV) risk factors associated to CV disease and type 2 diabetes. It is still under debate whether MS is a mere aggregation of risk factors or it represents a clinical entity with visceral obesity as underlying pathophysiological trigger. The publication of several diagnostic criteria of MS by scientific associations or experts panels reflects this uncertainty in understanding the real nature of MS. Besides the metabolic disturbances of MS, as visceral obesity, hypertriglyceridemia, low HDL cholesterol, hypertension and hyperglycemia, novel mechanisms of arterial damage have been identified. This paper reviews the evidence showing that MS and MS factors are characterized by increased oxidative stress, a relevant factor contributing to the development of metabolic and cardiovascular complications. In the next future, the measure of plasma oxidative stress may contribute to identify a subset of MS patients at increased CV risk, candidates to more intensive therapies. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Hopps, E.; Caimi, G.] Univ Palermo, Dept Internal Med Cardiovasc & Renal Dis, Palermo, Italy.
   [Noto, D.; Averna, M. R.] Univ Palermo, Dept Clin Med & Emerging Dis, I-90127 Palermo, Italy.
C3 University of Palermo; University of Palermo
RP Caimi, G (corresponding author), Univ Palermo, Dept Internal Med Cardiovasc & Renal Dis, Palermo, Italy.
EM caimigre@unipa.it; avernam@unipa.it
RI Noto, Davide/AAA-9208-2019; Averna, Maurizio/U-9527-2017
OI Averna, Maurizio/0000-0003-3558-9209; Noto, Davide/0000-0002-5346-2829;
   Caimi, Gregorio/0000-0001-8964-255X
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NR 50
TC 270
Z9 305
U1 0
U2 26
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0939-4753
EI 1590-3729
J9 NUTR METAB CARDIOVAS
JI Nutr. Metab. Carbiovasc. Dis.
PD JAN
PY 2010
VL 20
IS 1
BP 72
EP 77
DI 10.1016/j.numecd.2009.06.002
PG 6
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism; Nutrition
   & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism;
   Nutrition & Dietetics
GA 629BQ
UT WOS:000280169400011
PM 19747805
DA 2025-06-11
ER

PT J
AU Mentis, AFA
   Lee, DH
   Roussos, P
AF Mentis, Alexios-Fotios A.
   Lee, Donghoon
   Roussos, Panos
TI Applications of artificial intelligence-machine learning for detection
   of stress: a critical overview
SO MOLECULAR PSYCHIATRY
LA English
DT Review; Early Access
ID POLYGENIC RISK; DISORDER; SCHIZOPHRENIA; IDENTIFICATION; TRAJECTORIES;
   SYSTEM; CLASSIFIERS; ASSOCIATION; PERSONALITY; PERFORMANCE
AB Psychological distress is a major contributor to human physiology and pathophysiology, and it has been linked to several conditions, such as auto-immune diseases, metabolic syndrome, sleep disorders, and suicidal thoughts and inclination. Therefore, early detection and management of chronic stress is crucial for the prevention of several diseases. Artificial intelligence (AI) and Machine Learning (ML) have promoted a paradigm shift in several areas of biomedicine including diagnosis, monitoring, and prognosis of disease. Here, our review aims to present some of the AI and ML applications for solving biomedical issues related to psychological stress. We provide several lines of evidence from previous studies highlighting that AI and ML have been able to predict stress and detect the brain normal states vs. abnormal states (notably, in post-traumatic stress disorder (PTSD)) with accuracy around 90%. Of note, AI/ML-driven technology applied to identify ubiquitously present stress exposure may not reach its full potential, unless future analytics focus on detecting prolonged distress through such technology instead of merely assessing stress exposure. Moving forward, we propose that a new subcategory of AI methods called Swarm Intelligence (SI) can be used towards detecting stress and PTSD. SI involves ensemble learning techniques to efficiently solve a complex problem, such as stress detection, and it offers particular strength in clinical settings, such as privacy preservation. We posit that AI and ML approaches will be beneficial for the medical and patient community when applied to predict and assess stress levels. Last, we encourage additional research to bring AI and ML into the standard clinical practice for diagnostics in the not-too-distant future.
C1 [Mentis, Alexios-Fotios A.] Univ Res Inst Maternal & Child Hlth & Precis Med, Athens, Greece.
   [Mentis, Alexios-Fotios A.] Natl & Kapodistrian Univ Athens, Aghia Sophia Childrens Hosp, UNESCO Chair Adolescent Hlth Care, Athens, Greece.
   [Lee, Donghoon; Roussos, Panos] Icahn Sch Med Mt Sinai, Dept Psychiat, New York, NY 10029 USA.
   [Lee, Donghoon; Roussos, Panos] Icahn Sch Med Mt Sinai, Friedman Brain Inst, New York, NY 10029 USA.
   [Lee, Donghoon; Roussos, Panos] Icahn Sch Med Mt Sinai, Inst Multiscale Biol, Dept Genet & Genom Sci, New York, NY 10029 USA.
   [Roussos, Panos] James J Peters VA Med Ctr, Mental Illness Res Educ & Clin Ctr VISN 2 South, Bronx, NY USA.
C3 National & Kapodistrian University of Athens; The Aghia Sophia
   Children's Hospital; Icahn School of Medicine at Mount Sinai; Icahn
   School of Medicine at Mount Sinai; Icahn School of Medicine at Mount
   Sinai; US Department of Veterans Affairs; Veterans Health Administration
   (VHA); James J. Peters VA Medical Center
RP Mentis, AFA (corresponding author), Univ Res Inst Maternal & Child Hlth & Precis Med, Athens, Greece.; Mentis, AFA (corresponding author), Natl & Kapodistrian Univ Athens, Aghia Sophia Childrens Hosp, UNESCO Chair Adolescent Hlth Care, Athens, Greece.
EM amentis1@jhu.edu
RI Mentis, Alexios-Fotios/AAT-5274-2021
OI Mentis, Alexios-Fotios/0000-0002-1480-390X
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NR 148
TC 24
Z9 24
U1 5
U2 27
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 1359-4184
EI 1476-5578
J9 MOL PSYCHIATR
JI Mol. Psychiatr.
PD 2023 APR 5
PY 2023
DI 10.1038/s41380-023-02047-6
EA APR 2023
PG 13
WC Biochemistry & Molecular Biology; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Neurosciences & Neurology; Psychiatry
GA C8UZ2
UT WOS:000964619100004
PM 37020048
DA 2025-06-11
ER

PT J
AU Lee, KJ
   Hur, J
   Yang, KS
   Lee, MK
   Lee, SJ
AF Lee, Kyung Ju
   Hur, Junguk
   Yang, Kyung-Sook
   Lee, Mi-Kyoung
   Lee, Sung-Jae
TI Acute Biophysical Responses and Psychological Effects of Different Types
   of Forests in Patients With Metabolic Syndrome
SO ENVIRONMENT AND BEHAVIOR
LA English
DT Article
DE forest therapy; metabolic syndrome; biophysical parameter; oxidative
   stress; profile of mood state
ID NATURAL-KILLER ACTIVITY; MITOCHONDRIAL DYSFUNCTION; INSULIN-RESISTANCE;
   ANTICANCER PROTEINS; PUBLIC-HEALTH; AIR-POLLUTION; KNOCKOUT MICE;
   SHINRIN-YOKU; CARE; ENVIRONMENTS
AB We aimed to examine the biophysical and psychological effects of two different types of forests on women with metabolic syndrome (MetS). Seventy-one middle-aged Korean women participated in a half-day healing program at either Saneum Recreational Forest (a wild forest) or Seoul Forest (a tended forest) depending on their preference. The participants' biophysical parameters and Profile of Mood States (POMS) were measured before and after the healing program. The two groups differed significantly in acute insulin responses, pulse rate, oxidative stress markers, and stress hormone level, suggesting better homeostasis in the wild forest. The POMS suggested that the mean vigor and confusion scores significantly decreased in the wild forest. Considering the significantly more favorable acute insulin reaction and levels of oxidative stress and the trend toward positive mood state in the wild forest, we recommend that middle-aged patients with MetS participate in healing programs in wild forests.
C1 [Lee, Kyung Ju; Lee, Mi-Kyoung; Lee, Sung-Jae] Korea Univ, Coll Med, Integrat Med, Seoul, South Korea.
   [Yang, Kyung-Sook] Korea Univ, Coll Med, Biostat, Seoul, South Korea.
   [Hur, Junguk] Univ North Dakota, Sch Med & Hlth Sci, Biomed Sci, Grand Forks, ND USA.
C3 Korea University; Korea University Medicine (KU Medicine); Korea
   University; Korea University Medicine (KU Medicine); University of North
   Dakota Grand Forks
RP Lee, KJ; Lee, SJ (corresponding author), Korea Univ, Coll Med, Integrated Med Ctr, Inchon Ro 73, Seoul 136705, South Korea.
EM drlkj52551@korea.ac.kr; lee3676@korea.ac.kr
RI Lee, Kyung Ju/AFL-9687-2022; Hur, Junguk/J-6229-2019
OI Hur, Junguk/0000-0002-0736-2149; Lee, Kyung Ju/0000-0003-4655-1521
FU Korea Forest Service [S211215L010130]
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: This work
   was supported by the Korea Forest Service (Award S211215L010130). The
   funder had no role in the study design, data collection and analysis,
   decision to publish, or preparation of the article.
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NR 60
TC 31
Z9 32
U1 3
U2 48
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0013-9165
EI 1552-390X
J9 ENVIRON BEHAV
JI Environ. Behav.
PD APR
PY 2018
VL 50
IS 3
BP 298
EP 323
DI 10.1177/0013916517700957
PG 26
WC Environmental Studies; Psychology, Multidisciplinary
WE Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Psychology
GA GC4ZM
UT WOS:000429795200003
DA 2025-06-11
ER

PT J
AU Janney, CA
   Fagiolini, A
   Swartz, HA
   Jakicic, JM
   Holleman, RG
   Richardson, CR
AF Janney, Carol A.
   Fagiolini, Andrea
   Swartz, Holly A.
   Jakicic, John M.
   Holleman, Robert G.
   Richardson, Caroline R.
TI Are adults with bipolar disorder active? Objectively measured physical
   activity and sedentary behavior using accelerometry
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Actigraphy; Bipolar disorder; Physical activity; Sedentary behavior;
   NHANES 2003-2004; Mental health services
ID PSYCHOMOTOR ACTIVITY; METABOLIC SYNDROME; SYMPTOMATIC STATUS; MEDICAL
   BURDEN; TIME SPENT; RELIABILITY; VALIDITY; OBESITY; ISSUES; TRIAL
AB Background: Little is known about physical activity and sedentary behavior of adults with bipolar disorder (BP). Physical activity and sedentary behaviors may be modifiable factors associated with elevated rates of obesity, diabetes, cardiovascular disease, metabolic syndrome, and mortality in adults with BR
   Methods: Sixty adult outpatients treated for BP ( > 18 yr) wore accelerometers for seven consecutive days. Each minute epoch was assigned an activity level based on the number of counts per minute; sedentary( <100 counts), light(101-1951 counts), or moderate/vigorous( > 1952 counts). Adults with BP were matched 1:1 to users and non-users of mental health services (MHS) (NHANES 2003-2004) by gender, closest BMI, and age.
   Results: On average, adults with BP wore actigraphs over 17 h/day. The majority of monitoring time (78%,) was classified as sedentary (approximately 13.5 h/day). Light physical activity accounted for 21% of the monitoring time/day (215 min/day). None achieved 150 min/wk of moderate/vigorous activity as recommended by national guidelines. Adults with BP were significantly less active and more sedentary than MHS users and non-users in NHANES 2003-2004 (p < 0.01).
   Limitations: Majority of the participants were relatively asymptomatic with most (87%) having no more than mild depressive symptoms and none experiencing severe manic symptoms. The sedating effects of medications on physical activity were not investigated.
   Conclusion: From clinical perspectives, these findings justify physical activity interventions targeting adults with BP as a possible means to improve their physical and mental health and to reduce the elevated risk of commonly observed medical comorbidities in this high risk population. (C) 2013 Elsevier B.V. All rights reserved
C1 [Janney, Carol A.; Swartz, Holly A.] Univ Pittsburgh, Sch Med, Western Psychiat Inst & Clin, Pittsburgh, PA 15213 USA.
   [Janney, Carol A.] Univ Pittsburgh, Dept Epidemiol, Sch Publ Hlth, Pittsburgh, PA 15213 USA.
   [Fagiolini, Andrea] Univ Siena, Div Psychiat, Dept Mol & Dev Med, I-53100 Siena, Italy.
   [Fagiolini, Andrea] Univ Siena, Med Ctr, Dept Mental Hlth, I-53100 Siena, Italy.
   [Jakicic, John M.] Univ Pittsburgh, Dept Hlth & Phys Act, Pittsburgh, PA 15213 USA.
   [Holleman, Robert G.; Richardson, Caroline R.] Ann Arbor Vet Affair Med Ctr, Ann Arbor, MI USA.
   [Richardson, Caroline R.] Univ Michigan Hlth Syst, Dept Family Med, Ann Arbor, MI USA.
   [Richardson, Caroline R.] Hlth Serv Res & Dev Ctr Excellence, Ann Arbor, MI USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE); University
   of Pittsburgh; Western Psychiatric Institute & Clinic of UPMC;
   Pennsylvania Commonwealth System of Higher Education (PCSHE); University
   of Pittsburgh; University of Siena; University of Siena; Pennsylvania
   Commonwealth System of Higher Education (PCSHE); University of
   Pittsburgh; University of Michigan System; University of Michigan
RP Janney, CA (corresponding author), VA Ann Arbor Healthcare Syst, VA Ctr Clin Management Res, 2215 Fuller Rd,Mail Stop 152, Ann Arbor, MI 48105 USA.
EM carol.janney@va.gov
RI Richardson, Caroline/A-9237-2009; Swartz, Holly/G-5887-2012; FAGIOLINI,
   ANDREA/T-2772-2017
OI Richardson, Caroline/0000-0002-1945-6046; Janney,
   Carol/0000-0002-4821-4679; FAGIOLINI, ANDREA/0000-0001-5827-0853;
   Swartz, Holly/0000-0002-7611-9900
FU Charles F. Kline and Actigraph, Inc.; NHLBI [K23HL07598]; NIA
   [K01AG025962]; National Institute of Diabetes and Digestive and Kidney
   Diseases [P30DK020572] Funding Source: NIH RePORTER
FX PARC2 study was partially funded by Charles F. Kline and Actigraph, Inc.
   The actigraphy programming for PARC2 and NHANES 2003-2004 study was
   partially supported by Career Development Awards from NHLBI (K23HL07598)
   (Richardson) and NIA (K01AG025962) (Strath).
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NR 46
TC 90
Z9 94
U1 0
U2 21
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD JAN
PY 2014
VL 152
BP 498
EP 504
DI 10.1016/j.jad.2013.09.009
PG 7
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA 262UP
UT WOS:000327763600071
PM 24095103
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Cocate, PG
   Natali, AJ
   de Oliveira, A
   Alfenas, RDG
   Peluzio, MDG
   Longo, GZ
   dos Santos, EC
   Buthers, JM
   de Oliveira, LL
   Hermsdorff, HHM
AF Cocate, Paula G.
   Natali, Antonio Jose
   de Oliveira, Alessandro
   Alfenas, Rita de Cassia G.
   Peluzio, Maria do Carmo G.
   Longo, Giana Z.
   dos Santos, Eliziaria C.
   Buthers, Jessica M.
   de Oliveira, Leandro L.
   Hermsdorff, Helen Hermana M.
TI Red but not white meat consumption is associated with metabolic
   syndrome, insulin resistance and lipid peroxidation in Brazilian
   middle-aged men
SO EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
LA English
DT Article
DE Meat; abdominal obesity; metabolic syndrome; oxidized LDL
ID CORONARY-ARTERY-DISEASE; OXIDATIVE STRESS; DENSITY-LIPOPROTEIN; RISK;
   IRON; INCREASES; HEME; FAT
AB Background The influence of diet on metabolic syndrome and oxidative stress are not completely known.
   Design This cross-sectional study assessed the association of red meat and white meat consumption with metabolic syndrome, insulin resistance and lipid peroxidation in Brazilian middle-aged men.
   Methods A total of 296 subjects (age: 50.55.0 years, body mass index: 25.83.5kg/m(2)) were evaluated. Anthropometry, lifestyle features, blood biochemical parameters, diagnosis of metabolic syndrome, homeostatic model assessment for insulin resistance, a lipid peroxidation marker (oxidized low-density lipoprotein) and triglycerides:high-density lipoprotein cholesterol ratio were assessed. Dietary intake was estimated by a food frequency questionnaire.
   Results The subjects included in the highest tertile red meat (81.5g/d) and saturated fatty acid from red meat consumption (4.3g/d) had higher occurrence of central obesity (nearly 60%, p<0.01), hypertriglyceridaemia (nearly 43%, p<0.01) and metabolic syndrome (35%, p<0.01). They also had higher values of homeostatic model assessment for insulin resistance, oxidized low-density lipoprotein, and triglycerides:high-density lipoprotein cholesterol ratio, regardless of interfering factors. There were no associations of highest white meat tertile (39.4g/d) and saturated fatty acid from white meat (1.0g/d) consumption with the assessed parameters (p>0.05).
   Conclusions Red meat consumption was cross-sectionally associated with the occurrence of central obesity, hypertriglyceridaemia, and metabolic syndrome as well as with higher homeostatic model assessment for insulin resistance, oxidized low-density lipoprotein concentrations and triglycerides:high-density lipoprotein cholesterol ratio. The content of saturated fatty acid from red meat consumption may be a factor that contributed to this relationship, while white meat consumption was not associated with metabolic syndrome and the assessed biomarkers.
C1 [Cocate, Paula G.; de Oliveira, Alessandro; Alfenas, Rita de Cassia G.; Peluzio, Maria do Carmo G.; Longo, Giana Z.; Buthers, Jessica M.; Hermsdorff, Helen Hermana M.] Univ Fed Vicosa, Dept Nutr & Hlth, BR-36571000 Vicosa, MG, Brazil.
   [Natali, Antonio Jose] Univ Fed Vicosa, Dept Phys Educ, BR-36571000 Vicosa, MG, Brazil.
   [dos Santos, Eliziaria C.; de Oliveira, Leandro L.] Univ Fed Vicosa, Dept Gen Biol, BR-36571000 Vicosa, MG, Brazil.
C3 Universidade Federal de Vicosa; Universidade Federal de Vicosa;
   Universidade Federal de Vicosa
RP Hermsdorff, HHM (corresponding author), Univ Fed Vicosa, Dept Nutr & Hlth, Ave PH Rolfs, BR-36571000 Vicosa, MG, Brazil.
EM helenhermana@ufv.br
RI de Oliveira, Alessandro/ABF-5840-2021; LONGO, GIANA/AAX-6501-2020;
   santos, Eliziaria/M-3107-2017; Licursi de Oliveira, Leandro/D-3616-2009;
   Natali, Antonio Jose/C-1555-2013; Hermsdorff, Helen Hermana
   Miranda/H-4525-2015; Guedes Cocate, Paula/P-7621-2018
OI santos, Eliziaria/0000-0003-0825-5836; PELUZIO, MARIA DO CARMO
   GOUVEIA/0000-0003-4665-7043; Licursi de Oliveira,
   Leandro/0000-0003-4353-7011; Santos, Eliziaria
   Cardoso/0000-0002-3030-7746; Natali, Antonio Jose/0000-0002-4927-4024;
   de Oliveira, Alessandro/0000-0003-3510-7070; Hermsdorff, Helen Hermana
   Miranda/0000-0002-4441-6572; Guedes Cocate, Paula/0000-0003-1208-6481;
   Alfenas, Rita/0000-0003-2290-1611
FU Foundation for Research Support of the State of Minas Gerais (FAPEMIG)
   [CDS-APQ-02189-10]
FX This study was supported by the Foundation for Research Support of the
   State of Minas Gerais (FAPEMIG, CDS-APQ-02189-10). AJN, MCGP, RCGA are
   CNPq fellows.
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NR 46
TC 56
Z9 62
U1 0
U2 21
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 2047-4873
EI 2047-4881
J9 EUR J PREV CARDIOL
JI Eur. J. Prev. Cardiol.
PD FEB
PY 2015
VL 22
IS 2
BP 223
EP 230
DI 10.1177/2047487313507684
PG 8
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA AZ3GL
UT WOS:000348115400013
PM 24104887
OA Bronze
DA 2025-06-11
ER

PT J
AU Wischik, DL
   Magny-Normilus, C
   Whittemore, R
AF Wischik, Dora Lendvai
   Magny-Normilus, Cherlie
   Whittemore, Robin
TI Risk Factors of Obesity in Veterans of Recent Conflicts: Need for
   Diabetes Prevention
SO CURRENT DIABETES REPORTS
LA English
DT Review
DE Obesity; Young veterans; OEF; OIF; OND; Mental health; Transition to
   civilian life
ID POSTTRAUMATIC-STRESS-DISORDER; MILITARY SEXUAL TRAUMA; MENTAL-HEALTH
   DIAGNOSES; BODY-MASS INDEX; IRAQI FREEDOM; PSYCHIATRIC COMORBIDITY;
   AFGHANISTAN VETERANS; GENDER-DIFFERENCES; METABOLIC SYNDROME;
   EATING-DISORDERS
AB Purpose of ReviewTo identify factors associated with obesity in veterans of the recent, Operation Enduring Freedom (OEF), Operation Iraqi Freedom (OIF), and Operation New Dawn (OND) war conflicts.Recent FindingsOver 44% OEF/OIF/OND veterans are obese (BMI>30kg/m(2)), which exceeds the national obesity prevalence rate of 39% in people younger than 45. Obesity increases morbidity, risk for type 2 diabetes (T2D), and mortality as well as decreases quality of life. A scoping review method was used to identify factors associated with obesity in young veterans. Military exposures, such as multiple deployments and exposure to combat, contribute to challenges in re-integration to civilian life in all veterans. Factors that contribute to increased risk for obesity include changes in eating patterns/eating disorders, changes in physical activity, physical disability, and psychological comorbidity. These conditions can contribute to a rapid weight gain trajectory, changes in metabolism, and obesity.SummaryYoung veterans face considerable challenges related to obesity risk. Further research is needed to better understand young veterans' experiences and health needs in order to adapt or expand existing programs and improve access, engagement, and metabolic outcomes in this vulnerable population.
C1 [Wischik, Dora Lendvai; Magny-Normilus, Cherlie; Whittemore, Robin] Yale Sch Nursing, 400 West Campus Dr, Orange, CT 06477 USA.
C3 Yale University
RP Wischik, DL (corresponding author), Yale Sch Nursing, 400 West Campus Dr, Orange, CT 06477 USA.
EM dora.wischik@yale.edu; cherlie.magny-normilus@yale.edu;
   robin.whittemore@yale.edu
RI Magny-Normilus, Cherlie/AFO-5407-2022
OI Magny-Normilus, Cherlie/0000-0002-5514-7996; Lendvai,
   Dora/0000-0002-5712-6638
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NR 84
TC 17
Z9 21
U1 2
U2 13
PU CURRENT MEDICINE GROUP
PI PHILADELPHIA
PA 400 MARKET STREET, STE 700, PHILADELPHIA, PA 19106 USA
SN 1534-4827
EI 1539-0829
J9 CURR DIABETES REP
JI Curr. Diabetes Rep.
PD SEP
PY 2019
VL 19
IS 9
AR 70
DI 10.1007/s11892-019-1191-9
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism
GA IM5SF
UT WOS:000478052900001
PM 31368008
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Gonzalez-Uribe, V
   de la Cruz, HV
   Gomez-Nuñez, A
   Leyva-Calderon, JA
   Mojica-Gonzalez, ZS
AF Gonzalez-Uribe, Victor
   Vidaurri-de la Cruz, Helena
   Gomez-Nunez, Andres
   Leyva-Calderon, Jordi A.
   Mojica-Gonzalez, Zaira S.
TI Comorbidities & burden of disease in atopic dermatitis
SO ASIAN PACIFIC JOURNAL OF ALLERGY AND IMMUNOLOGY
LA English
DT Review
DE Atopic dermatitis; Comorbidity; Asthma; Allergic rhinitis; Vitiligo;
   Mental Health
ID ALOPECIA-AREATA; MYOCARDIAL-INFARCTION; RISK; ASSOCIATION; POPULATION;
   ADULTS; VITILIGO; DISORDER; CHILDREN; HEALTH
AB Background: Atopic dermatitis is associated with an increased frequency of other atopic & allergic manifestations, including asthma in 10% to 30% of cases depending on age, allergic rhinitis, food allergies, eosinophilic diseases, and allergic conjunctivitis. The comorbidities outside the atopic march are overall less frequent than in psoriasis.Objective: This review aims to demonstrate the intense, broad burden of this disease, comorbidities and its multidimensional involvement as a complex, heterogeneous disease.Methods: The present narrative review summarizes the findings from the world's largest epidemiological studies and smaller, AD-specific studies on the comorbidities and burdens of this disease.Results: The risk of asthma, specifically, and other atopic manifestations and skin infections, generally, is clearly increased among patients with AD. Of the other skin diseases, there is an undeniable risk of alopecia areata, vitiligo, and contact eczema and a lower risk of developing other autoimmune diseases. While comorbidities exist, their frequency seems to be modified by lifestyle, particularly by smoking. There is a link with overweight, obesity, and metabolic syndrome, especially in severe AD. This is also the case for cardiovascular diseases; however, with OR/HRs below 1.5. There is no link to type II diabetes but, rather, to type I in children. In all other areas, the data are often inconsistent, and any increase in risk is low. Eye diseases seem to be the only exception. AD also has psychiatric consequences, including attention-hyperactivity disorder, anxiety, depression, and sometimes suicidality, especially when severe.Conclusions: The recently published work largely confirms our existing understanding of AD.
C1 [Gonzalez-Uribe, Victor; Gomez-Nunez, Andres; Leyva-Calderon, Jordi A.] Univ La Salle, Fac Mexicana Med, Mexico City, Mexico.
   [Gonzalez-Uribe, Victor] Dalinde Corta Estancia, AlergiaMX, Mexico City, Mexico.
   [Vidaurri-de la Cruz, Helena] Hosp Gen Mexico Dr Eduardo Liceaga, Pediat Dermatol Serv, Mexico City, Mexico.
   [Mojica-Gonzalez, Zaira S.] Lab Juarez, Pathol Mol Biol & Immunohistochem, Mexico City, Mexico.
   [Gonzalez-Uribe, Victor] Mier & Pesado 222-412,Benito Juarez, Mexico City 03100, Mexico.
RP Gonzalez-Uribe, V (corresponding author), Mier & Pesado 222-412,Benito Juarez, Mexico City 03100, Mexico.
EM dr.victorgonzalezu@gmail.com
RI Gonzalez, Victor/JEP-7736-2023
OI Gomez Nunez, Carlos Andres/0009-0002-3800-3066; Gonzalez Uribe,
   Victor/0000-0001-9053-7108
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NR 70
TC 12
Z9 14
U1 1
U2 6
PU ALLERGY IMMUNOL SOC THAILAND
PI BANGKOK
PA DIV ALLERGY & CLINICAL IMMUNOLOGY, DEPT MEDICINE, CHULALONGKORN UNIV,
   BANGKOK 10330, THAILAND
SN 0125-877X
EI 2228-8694
J9 ASIAN PAC J ALLERGY
JI Asian Pac. J. Allergy Immunol.
PD JUN
PY 2023
VL 41
IS 2
BP 97
EP 105
DI 10.12932/AP-231022-1484
PG 9
WC Allergy; Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Allergy; Immunology
GA L4AB9
UT WOS:001022690900001
PM 37392397
OA gold
DA 2025-06-11
ER

PT J
AU Meshkat, S
   Duffy, SF
   Tassone, VK
   Lin, QW
   Pang, HYM
   Jung, H
   Lou, W
   Bhat, V
AF Meshkat, Shakila
   Duffy, Sophie F.
   Tassone, Vanessa K.
   Lin, Qiaowei
   Pang, Hilary Y. M.
   Jung, Hyejung
   Lou, Wendy
   Bhat, Venkat
TI Increased odds of metabolic syndrome among adults with depressive
   symptoms or antidepressant use
SO TRANSLATIONAL PSYCHIATRY
LA English
DT Article
ID LONG-TERM USE; SYNDROME ABNORMALITIES; MAJOR DEPRESSION; WEIGHT-GAIN;
   SEVERITY; RISK; ASSOCIATION; DISORDER; DISEASE; ANXIETY
AB Metabolic syndrome (MetS) is a condition that includes a cluster of risk factors for cardiovascular disease. In this paper, we aimed to evaluate the association between depressive symptoms, antidepressant use, duration of antidepressant use, antidepressant type and MetS. Data from the 2005-2018 National Health and Nutrition Examination Surveys were used in this study. Adults were included if they responded to the depressive symptoms and prescription medications questionnaires and had measures of blood pressure, waist circumference, triglycerides, high-density lipoprotein, and fasting plasma glucose. Participants were categorized by their antidepressant use (yes/no), type, and duration. This study included 14,875 participants (50.45% females), with 3616 (23.45%) meeting the criteria for MetS. Participants with higher depressive symptom scores (aOR = 1.04, 95% CI: 1.02, 1.05, p < 0.001) or those with depressive symptoms (aOR = 1.42, 95% CI: 1.17, 1.73, p = 0.001) had higher odds of MetS. A similar associations was seen among those who were on antidepressants compared to those who were not on antidepressants (aOR = 1.24, 95% CI: 1.03, 1.50, p = 0.025). Duration of antidepressant use was not significantly associated with MetS. Participants on tricyclic antidepressants had greater odds of MetS compared to those not taking any antidepressants (aOR = 2.27, 95% CI: 1.31, 3.93, p = 0.004). Our study provides evidence of the association between depressive symptoms, antidepressant use, and MetS, highlighting the importance of monitoring metabolic and cardiovascular alterations in individuals of depression.
C1 [Meshkat, Shakila; Duffy, Sophie F.; Tassone, Vanessa K.; Lin, Qiaowei; Bhat, Venkat] Unity Hlth Toronto, St Michaels Hosp, Intervent Psychiat Program, Toronto, ON, Canada.
   [Lin, Qiaowei; Jung, Hyejung; Lou, Wendy] Univ Toronto, Dalla Lana Sch Publ Hlth, Dept Biostat, Toronto, ON, Canada.
   [Pang, Hilary Y. M.; Bhat, Venkat] Univ Toronto, Dept Psychiat, Toronto, ON, Canada.
   [Bhat, Venkat] Univ Toronto, Inst Med Sci, Toronto, ON, Canada.
   [Bhat, Venkat] Unity Hlth Toronto, St Michaels Hosp, Mental Hlth & Addict Serv, Toronto, ON, Canada.
C3 University of Toronto; Saint Michaels Hospital Toronto; University of
   Toronto; University of Toronto; University of Toronto; University of
   Toronto; Saint Michaels Hospital Toronto
RP Bhat, V (corresponding author), Unity Hlth Toronto, St Michaels Hosp, Intervent Psychiat Program, Toronto, ON, Canada.; Bhat, V (corresponding author), Univ Toronto, Dept Psychiat, Toronto, ON, Canada.; Bhat, V (corresponding author), Univ Toronto, Inst Med Sci, Toronto, ON, Canada.; Bhat, V (corresponding author), Unity Hlth Toronto, St Michaels Hosp, Mental Hlth & Addict Serv, Toronto, ON, Canada.
EM venkat.bhat@utoronto.ca
RI Meshkat, Shakila/HHZ-1030-2022
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NR 74
TC 0
Z9 0
U1 3
U2 3
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 2158-3188
J9 TRANSL PSYCHIAT
JI Transl. Psychiatr.
PD FEB 27
PY 2025
VL 15
IS 1
AR 68
DI 10.1038/s41398-025-03289-4
PG 9
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychiatry
GA Y9C4O
UT WOS:001435011300002
PM 40016233
OA gold
DA 2025-06-11
ER

PT J
AU Pace, C
   Smith-Gagen, J
   Angermann, J
AF Pace, Clare
   Smith-Gagen, Julie
   Angermann, Jeff
TI Arsenic Methylation Capacity and Metabolic Syndrome in the 2013-2014 US
   National Health and Nutrition Examination Survey (NHANES)
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Article
DE arsenic; methylation; metabolic syndrome; U; S; NHANES
ID URINARY HEAVY-METAL; HIGH BLOOD-PRESSURE; OXIDATIVE STRESS;
   DRINKING-WATER; ENVIRONMENTAL EXPOSURE; KAPPA-B; POPULATION; RISK;
   PHTHALATE; HYPERTENSION
AB Arsenic methylation capacity is associated with metabolic syndrome and its components among highly exposed populations. However, this association has not been investigated in low to moderately exposed populations. Therefore, we investigated arsenic methylation capacity in relation to the clinical diagnosis of metabolic syndrome in a low arsenic exposure population. Additionally, we compared arsenic methylation patterns present in our sample to those of more highly exposed populations. Using logistic regression models adjusted for relevant biological and lifestyle covariates, we report no association between increased arsenic methylation and metabolic syndrome in a population in which arsenic is regulated at 10 ppb in drinking water. However, we cannot rule out the possibility of a positive association between arsenic methylation and metabolic syndrome in a subsample of women with normal body mass index (BMI). To our knowledge this is the first investigation of arsenic methylation capacity with respect to metabolic syndrome in a low exposure population. We also report that methylation patterns in our sample are similar to those found in highly exposed populations. Additionally, we report that gender and BMI significantly modify the effect of arsenic methylation on metabolic syndrome. Future studies should evaluate the effectiveness of arsenic policy enforcement on subclinical biomarkers of cardiovascular disease.
C1 [Pace, Clare] Univ Nevada, Dept Environm Sci, Reno, NV 89557 USA.
   [Smith-Gagen, Julie; Angermann, Jeff] Univ Nevada, Sch Community Hlth Sci, Reno, NV 89557 USA.
C3 Nevada System of Higher Education (NSHE); University of Nevada Reno;
   Nevada System of Higher Education (NSHE); University of Nevada Reno
RP Angermann, J (corresponding author), Univ Nevada, Sch Community Hlth Sci, Reno, NV 89557 USA.
EM clare.pace@gmail.com; jsmithgagen@unr.edu; jeffa@unr.edu
OI Angermann, Jeff/0000-0001-8949-6492
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   World Health Organization, 2001, INT PROGR CHEM SAF A, V224
NR 53
TC 22
Z9 24
U1 0
U2 13
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD JAN
PY 2018
VL 15
IS 1
AR 168
DI 10.3390/ijerph15010168
PG 18
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA FU8QZ
UT WOS:000424121200167
PM 29361794
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Phillips, DIW
AF Phillips, DIW
TI Fetal programming of the neuroendocrine response to stress: Links
   between low birth weight and the metabolic syndrome
SO ENDOCRINE RESEARCH
LA English
DT Article; Proceedings Paper
CT 11th Conference on the Adrenal Cortex
CY JUN 12-15, 2004
CL New Orleans, LA
DE birth weight; metabolic syndrome; stress; fetal programming
ID PLASMA-CORTISOL CONCENTRATIONS; BLOOD-PRESSURE; GROWTH-RETARDATION;
   GLUCOSE-TOLERANCE; ABDOMINAL OBESITY; LATE PREGNANCY; ADRENAL AXIS;
   RISK; HYPERTENSION; ASSOCIATION
AB There is now substantial agreement that small size at birth is associated with increased rates of the metabolic syndrome (glucose intolerance, high blood pressure, and dyslipidaemia) and related pathologies including cardiovascular disease in adult life. Evidence is also emerging that suggests programming of hormonal systems in response to an adverse fetal environment may be one of the mechanisms underlying these long-term consequences of early life events. In particular, alterations in the neuroendocrine response to stress may play an important part. Recent research suggests that increased adrenocortical and sympathoadrenal responses are associated with small size at birth. Evidence from epidemiological studies shows that subtle alterations in these neuroendocrine systems appear to exert a powerful influence on the levels of cardiovascular risk factors including plasma glucose and lipid concentrations and blood pressure.
C1 Southampton Gen Hosp, MRC, Southampton SO16 6YD, Hants, England.
C3 University of Southampton
RP Southampton Gen Hosp, MRC, Tremona Rd, Southampton SO16 6YD, Hants, England.
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NR 36
TC 22
Z9 30
U1 0
U2 1
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 0743-5800
EI 1532-4206
J9 ENDOCR RES
JI Endocr. Res.
PY 2004
VL 30
IS 4
BP 819
EP 826
DI 10.1081/ERC-200044086
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Endocrinology & Metabolism
GA 887GQ
UT WOS:000226294200065
PM 15666832
DA 2025-06-11
ER

PT J
AU Green, MF
   Hirschey, MD
AF Green, Michelle F.
   Hirschey, Matthew D.
TI SIRT3 Weighs Heavily in the Metabolic Balance: A New Role for SIRT3 in
   Metabolic Syndrome
SO JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL
   SCIENCES
LA English
DT Article
DE Metabolic syndrome; Sirtuins; SIRT3
ID FATTY-ACID OXIDATION; CALORIE RESTRICTION; MITOCHONDRIAL; ACETYLATION
AB Eating a "Western diet" high in fat and sugars is associated with accelerated development of age-related metabolic diseases such as obesity, insulin resistance, and diabetes while incidences of these diseases are decreased on a low-caloric diet. The mitochondrial NAD(+)-dependent protein deacetylase SIRT3 has previously been shown to be important in adapting to metabolic stress brought on by fasting and calorie restriction. During times of metabolic stress, SIRT3 is upregulated and maintains homeostasis following nutrient deprivation by turning on pathways such as fatty acid oxidation, antioxidant production, and the urea cycle. New studies now demonstrate that SIRT3 is regulated during nutrient excess. During high-fat diet feeding, SIRT3 is downregulated leading to mitochondrial protein hyperacetylation. The consequence of this hyperacetylation is the accelerated development of metabolic syndrome. Thus, SIRT3 is emerging Os an important metabolic sensor working to restore metabolic homeostasis during times of stress.
C1 [Green, Michelle F.; Hirschey, Matthew D.] Duke Univ, Med Ctr, Sarah W Stedman Nutr & Metab Ctr, Durham, NC USA.
   [Hirschey, Matthew D.] Duke Univ, Med Ctr, Dept Med, Durham, NC 27710 USA.
   [Hirschey, Matthew D.] Duke Univ, Med Ctr, Dept Pharmacol & Canc Biol, Durham, NC USA.
C3 Duke University; Duke University; Duke University
RP Hirschey, MD (corresponding author), 4321 Med Pk Dr,Suite 200, Durham, NC 27704 USA.
EM matthew.hirschey@duke.edu
OI Hirschey, Matthew/0000-0003-4541-5376
FU Central Society for Clinical Research; American Heart Association
   [12SDG8840004, 12IRG9010008]; American Heart Association (AHA)
   [12SDG8840004, 12IRG9010008] Funding Source: American Heart Association
   (AHA)
FX Central Society for Clinical Research and the American Heart Association
   (grants 12SDG8840004 and 12IRG9010008 to M.D.H.).
CR Anderson KA, ESSAYS BIOC IN PRESS
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NR 23
TC 25
Z9 29
U1 0
U2 29
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1079-5006
EI 1758-535X
J9 J GERONTOL A-BIOL
JI J. Gerontol. Ser. A-Biol. Sci. Med. Sci.
PD FEB
PY 2013
VL 68
IS 2
BP 105
EP 107
DI 10.1093/gerona/gls132
PG 3
WC Geriatrics & Gerontology; Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA 069YW
UT WOS:000313474000001
PM 22562958
OA Bronze
DA 2025-06-11
ER

PT J
AU Shammas, NW
   Sica, DA
   Toth, PP
AF Shammas, Nicolas W.
   Sica, Domenic A.
   Toth, Peter P.
TI A Guide to the Management of Blood Pressure in the Diabetic Hypertensive
   Patient
SO AMERICAN JOURNAL OF CARDIOVASCULAR DRUGS
LA English
DT Review
ID CONVERTING ENZYME-INHIBITORS; LIPID-LOWERING TREATMENT;
   PROSPECTIVELY-DESIGNED OVERVIEWS; MAJOR CARDIOVASCULAR EVENTS;
   INSULIN-RESISTANCE SYNDROME; RENIN-ANGIOTENSIN SYSTEM; CALCIUM-CHANNEL
   BLOCKER; END-POINT REDUCTION; BETA-BLOCKERS; RENAL OUTCOMES
AB Diabetes mellitus and hypertension frequently coexist in patients with the insulin resistance syndrome (IRS). Patients with both diabetes and hypertension typically have widespread endothelial dysfunction, increased oxidative stress, an activated sympathoadrenal system, and an elevated systemic burden of inflammatory mediators. Patients with diabetes and hypertension also have concomitant mixed dyslipidemia and obesity with significant frequency, and are at high risk for the development of macro- and microvascular disease, congestive heart failure, and nephropathy. Current data suggest that ACE inhibitors or anglotensin receptor blockers with or without a diuretic are important, if not preferred, initial therapies for the patient with diabetes and hypertension. Other drug classes such as combined alpha-/beta-adrenoceptor antagonists, dihydropyridine calcium channel antagonists (CCAs), and peripheral alpha-adrenoceptor antagonists are also useful therapeutic options in these patients. In order to optimally reduce the risk for cardiovascular events in the patient with diabetes and hypertension, optimal BP control Should be coupled with comprehensive lifestyle modification and aggressive management of dyslipidemia and hyperglycemia.
C1 [Shammas, Nicolas W.; Toth, Peter P.] Midwest Cardiovasc Res Fdn, Davenport, IA 52803 USA.
   [Sica, Domenic A.] Virginia Commonwealth Univ, Dept Med, Med Ctr, Div Nephrol, Richmond, VA 23298 USA.
   [Toth, Peter P.] Sterling Rock Falls Clin, Sterling, IL USA.
   [Toth, Peter P.] Univ Illinois, Coll Med, Peoria, IL 61656 USA.
C3 Virginia Commonwealth University; University of Illinois System;
   University of Illinois Peoria
RP Shammas, NW (corresponding author), Midwest Cardiovasc Res Fdn, 1236 E Rusholme,Suite 300, Davenport, IA 52803 USA.
EM shammas@mchsi.com
RI Toth, Peter/GMW-6552-2022
FU Midwest Cardiovascular Research Foundation
FX Nicolas W. Shammas has received honoraria and educational grants (via
   the Midwest Cardiovascular Research Foundation) from Astra Zeneca,
   GlaxoSmithKline, Wyeth, Merck, and Schering-Plough. Dr Shammas has no
   stocks, investments or patent pending with these corporations. Domenic
   A. Sica has received consultancies and honoraria form Novartis,
   BoehringerIngelheim, and GlaxoSmith Kline. Dr Sica has received grants
   from Novartis. Peter P. Toth has received honoraria and grants from
   Merck, and Novartis. Dr Toth has received consultancies from Merck. No
   funding was used to prepare this review.
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NR 108
TC 8
Z9 9
U1 0
U2 6
PU ADIS INT LTD
PI NORTHCOTE
PA 5 THE WAREHOUSE WAY, NORTHCOTE 0627, AUCKLAND, NEW ZEALAND
SN 1175-3277
EI 1179-187X
J9 AM J CARDIOVASC DRUG
JI Am. J. Cardiovasc. Drugs
PY 2009
VL 9
IS 3
BP 149
EP 162
DI 10.1007/BF03256572
PG 14
WC Cardiac & Cardiovascular Systems; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Pharmacology & Pharmacy
GA 460RC
UT WOS:000267203800003
PM 19463021
DA 2025-06-11
ER

PT J
AU Lovallo, WR
   Farag, NH
   Sorocco, KH
   Cohoon, AJ
   Vincent, AS
AF Lovallo, William R.
   Farag, Noha H.
   Sorocco, Kristen H.
   Cohoon, Andrew J.
   Vincent, Andrea S.
TI Lifetime Adversity Leads to Blunted Stress Axis Reactivity: Studies from
   the Oklahoma Family Health Patterns Project
SO BIOLOGICAL PSYCHIATRY
LA English
DT Article
DE Cortisol; gender; heart rate; lifetime adversity; mental stress; stress
   reactivity
ID CARDIOVASCULAR REACTIVITY; INDIVIDUAL-DIFFERENCES; PSYCHOLOGICAL STRESS;
   CORTISOL RESPONSES; METABOLIC SYNDROME; EARLY ENVIRONMENT; CHILDHOOD
   TRAUMA; MATERNAL-CARE; HPA-AXIS; WOMEN
AB Background: Can stressful events in early life alter the response characteristics of the human stress axis? Individual differences in stress reactivity are considered potentially important in long-term health and disease; however, little is known about the sources of these individual differences. We present evidence that adverse experience in childhood and adolescence can alter core components of the stress axis, including cortisol and heart rate reactivity.
   Methods: We exposed 354 healthy young adults (196 women) to public speaking and mental arithmetic stressors in the laboratory. Stress responses were indexed by self-report, heart rate, and cortisol levels relative to measures on a nonstress control day. Subjects were grouped into those who had experienced 0, 1, or 2 or more significant adverse life events, including Physical or Sexual Adversity (mugged, threatened with a weapon, experienced a break-in or robbery or raped or sexually assaulted by a relative or nonrelative) or Emotional Adversity (separation from biological mother or father for at least 6 months before age 15).
   Results: Experience of adversity predicted smaller heart rate and cortisol responses to the stressors in a dose-dependent fashion (0 > 1 > 2 or more events) (F values = 5.79 and 8.11, p values < .004) for both men and women. This was not explained by differences in socioeconomic status, the underlying cortisol diurnal cycle, or subjective experience during the stress procedure.
   Conclusions: The results indicate a long-term impact of stressful life experience on the reactivity of the human stress axis.
C1 [Lovallo, William R.; Sorocco, Kristen H.; Cohoon, Andrew J.] Vet Affairs Med Ctr, Behav Sci Labs, Oklahoma City, OK 73104 USA.
   [Lovallo, William R.; Cohoon, Andrew J.] Univ Oklahoma, Hlth Sci Ctr, Dept Psychiat & Behav Sci, Oklahoma City, OK 73190 USA.
   [Farag, Noha H.] Univ Oklahoma, Hlth Sci Ctr, Coll Publ Hlth, Dept Epidemiol & Biostat, Oklahoma City, OK 73190 USA.
   [Sorocco, Kristen H.] Univ Oklahoma, Hlth Sci Ctr, Donald W Reynolds Dept Geriatr Med, Oklahoma City, OK 73190 USA.
   [Vincent, Andrea S.] Univ Oklahoma, Cognit Sci Res Ctr, Norman, OK 73019 USA.
C3 US Department of Veterans Affairs; Veterans Health Administration (VHA);
   University of Oklahoma System; University of Oklahoma Health Sciences
   Center; University of Oklahoma System; University of Oklahoma Health
   Sciences Center; University of Oklahoma System; University of Oklahoma
   Health Sciences Center; University of Oklahoma System; University of
   Oklahoma Health Sciences Center; University of Oklahoma System;
   University of Oklahoma - Norman
RP Lovallo, WR (corresponding author), Vet Affairs Med Ctr, Behav Sci Labs 151A, 921 NE 13th St, Oklahoma City, OK 73104 USA.
EM bill@mindbody1.org
RI Lovallo, William/E-9294-2010
OI Lovallo, William/0000-0002-8489-3509
FU Department of Veterans Affairs Medical Research Service; National
   Institutes of Health; National Institute on Alcohol Abuse and Alcoholism
   [R01 AA019691, R01 AA012207]; National Council on Research Resources
   [M01 RR014467]
FX This work was supported by the Department of Veterans Affairs Medical
   Research Service, the National Institutes of Health, National Institute
   on Alcohol Abuse and Alcoholism, Grants R01 AA019691 and R01 AA012207,
   and National Council on Research Resources, and Grant M01 RR014467. The
   content is solely the view of the authors and does not necessarily
   represent the official view of the National Institutes of Health or the
   Department of Veterans Affairs.
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NR 55
TC 206
Z9 242
U1 0
U2 40
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0006-3223
EI 1873-2402
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD FEB 15
PY 2012
VL 71
IS 4
BP 344
EP 349
DI 10.1016/j.biopsych.2011.10.018
PG 6
WC Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA 879FJ
UT WOS:000299314800013
PM 22112928
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Apryatin, SA
   Shipelin, VA
   Sidorova, YS
   Petrov, NA
   Gmoshinskii, IV
   Nikityuk, DB
AF Apryatin, S. A.
   Shipelin, V. A.
   Sidorova, Yu. S.
   Petrov, N. A.
   Gmoshinskii, I. V.
   Nikityuk, D. B.
TI Interspecific Differences in Behavioral Responses and Neuromotorics
   between Laboratory Rodents Receiving Rations with Easily Digested
   Carbohydrates
SO BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
LA English
DT Article
DE metabolic syndrome; rats; mice; in vivo models; behavioral responses
ID METABOLIC SYNDROME; MODEL
AB We assessed the effect of intake of easily digested carbohydrates for 133 days on quantitative parameters of neuromotorics and cognitive function in Wistar rats and C57Bl/6J mice. Neuromotorics (muscle tone) was assessed in rats and mice by the forelimb muscle force (grip strength) over 4 months. Anxiety was assessed in the elevated plus-maze test and cognitive function (short-term and long-term memory) was evaluated by conditioned passive avoidance response (CPAR) test over 3 months. The mice, in contrast to rats, receiving the diet with easily digested sugars demonstrated suppression of neuromotorics. Anxiety increased with age in female mice, but not in rats, irrespective of the diet. Cognitive function in rats receiving experimental rations did not change significantly in comparison with the control. In mice, consumption of equimolar mixture of fructose and glucose impared short-term, but not long-term memory, in comparison with the group receiving glucose alone. We revealed a small (by 14-17%), but statistically significant increase in the brain weight in mice receiving fructose and sucrose. The study demonstrates sufficient interspecies differences in the influence of carbohydrate rations on neuromotorics and behavioral responses in the in vivo metabolic syndrome model.
C1 [Apryatin, S. A.; Shipelin, V. A.; Sidorova, Yu. S.; Petrov, N. A.; Gmoshinskii, I. V.; Nikityuk, D. B.] Fed Res Ctr Nutr & Biotechnol, Moscow, Russia.
C3 Federal Research Center of Nutrition, Biotechnology & Food Safety
RP Shipelin, VA (corresponding author), Fed Res Ctr Nutr & Biotechnol, Moscow, Russia.
EM v.shipelin@yandex.ru
RI Sidorova, Yulia/S-2803-2016; Apryatin, Sergey/R-5394-2016; Petrov,
   Nikita/B-5315-2017; Nikitjuk, Dmitry/G-2079-2017; Shipelin,
   Vladimir/N-4692-2016
OI Petrov, Nikita/0000-0001-9755-6002; Nikitjuk,
   Dmitry/0000-0002-4968-4517; Kvarachelia, Anna/0000-0003-1624-634X;
   Shipelin, Vladimir/0000-0002-0015-8735
FU Federal Agency for Scientific Organizations [0529-2015-0006]
FX This study was supported by Federal Agency for Scientific Organizations
   (State Task No. 0529-2015-0006, "Search for New Molecular Markers of
   Alimentary-Dependent Diseases: Genomic and Postgenomic Analysis").
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   Brothers SP, 2010, EMBO MOL MED, V2, P429, DOI 10.1002/emmm.201000100
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NR 15
TC 3
Z9 5
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0007-4888
EI 1573-8221
J9 B EXP BIOL MED+
JI Bull. Exp. Biol. Med.
PD MAY
PY 2018
VL 165
IS 1
BP 5
EP 9
DI 10.1007/s10517-018-4086-x
PG 5
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA GH8HI
UT WOS:000433908500002
DA 2025-06-11
ER

PT J
AU Foreyt, JP
AF Foreyt, JP
TI Need for lifestyle intervention: How to begin
SO AMERICAN JOURNAL OF CARDIOLOGY
LA English
DT Article; Proceedings Paper
CT Symposium on Impending Epidemic of Obesity, Metabolic Syndrome and
   Diabetes Mellitus
CY OCT 02, 2004
CL Tucson, AZ
SP Midwest Heart Fdn
ID WEIGHT-LOSS
AB The metabolic syndrome is the fastest growing disease entity in the world. Prevention and effective treatment emphasize lifestyle intervention, including healthful diet, physical activity, and pharmacologic agents to target specific risk factors. Weight loss improves all aspects of the metabolic syndrome and is a primary intervention target. Effective Weight management also helps prevent the development of the metabolic syndrome. Lifestyle change strategies-including setting reasonable goals, raising awareness, confronting barriers to change, managing stress, cognitive restructuring, preventing relapse, and providing support-are the keys to long-term success. (c) 2005 Elsevier Inc. All rights reserved.
C1 Baylor Coll Med, Dept Med, Houston, TX 77030 USA.
C3 Baylor College of Medicine
RP 6655 Travis St,320, Houston, TX 77030 USA.
EM jforeyt@bcm.edu
FU NIDDK NIH HHS [DK058299] Funding Source: Medline
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NR 17
TC 33
Z9 37
U1 0
U2 3
PU EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
PI BRIDGEWATER
PA 685 ROUTE 202-206 STE 3, BRIDGEWATER, NJ 08807 USA
SN 0002-9149
EI 1879-1913
J9 AM J CARDIOL
JI Am. J. Cardiol.
PD AUG 22
PY 2005
VL 96
IS 4A
SU S
BP 11E
EP 14E
DI 10.1016/j.amjcard.2005.05.009
PG 4
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI); Conference Proceedings Citation Index - Science (CPCI-S)
SC Cardiovascular System & Cardiology
GA 956OF
UT WOS:000231308900004
PM 16098837
DA 2025-06-11
ER

PT J
AU Amiri, A
   Chovanec, M
   Oliva, V
   Sedliak, M
   Mego, M
   Ukropec, J
   Ukropcová, B
AF Amiri, Ali
   Chovanec, Michal
   Oliva, Viktor
   Sedliak, Milan
   Mego, Michal
   Ukropec, Jozef
   Ukropcova, Barbara
TI Chemotherapy-induced toxicity in patients with testicular germ cell
   tumors: The impact of physical fitness and regular exercise
SO ANDROLOGY
LA English
DT Review
DE chemotherapy-related toxicity; exercise; physical fitness; testicular
   germ cell tumors; TGCT cancer survivors
ID LONG-TERM SURVIVORS; INDUCED PERIPHERAL NEUROPATHY; CANCER-RELATED
   FATIGUE; QUALITY-OF-LIFE; ADVERSE HEALTH OUTCOMES; BREAST-CANCER;
   METABOLIC SYNDROME; COGNITIVE IMPAIRMENT; RESISTANCE EXERCISE;
   RISK-FACTORS
AB Background Testicular germ cell tumors (TGCTs) represent similar to 95% of testicular malignancies and are the most common type of malignancy in young male adults. While the incidence of TGCTs has increased during the last decades, the advances in treatment, namely introducing cisplatin into the chemotherapy regimen, have made TGCTs highly curable with the 10-year survival rate exceeding 95%. However, in parallel with increased cure rates, survivors may experience acute and late adverse effects of treatment, which increase morbidity, reduce the quality of life, and can be potentially life-threatening. Chemotherapy-related toxicities include cardiovascular and metabolic diseases, secondary cancer, avascular necrosis, cognitive impairment, cancer-related fatigue, poor mental health-related quality of life, nephrotoxicity, hypogonadism, neurotoxicity, pulmonary toxicity, anxiety, and depression. These treatment-related adverse effects have emerged as important survivorship dilemmas in TGCT cancer survivors. Recently, regular physical exercise has increasingly attracted research and clinical attention as an adjunct therapy for cancer patients. Purpose Herein, we review the most common chemotherapy-related adverse effects in TGCT survivors and clinical relevance of exercise and increased cardio-respiratory fitness in modulating chemotherapy-related toxicity and quality of life in this population. Results and conclusion Exercise has positive effects on a spectrum of physical and psychosocial outcomes during and after cancer treatment, and current guidelines on exercise prescription in chronic diseases define the recommended dose (volume and intensity) of regular exercise for cancer survivors, highlighting regular, sufficiently intensive physical activity as an essential part of patients' care.
C1 [Amiri, Ali; Ukropec, Jozef; Ukropcova, Barbara] Slovak Acad Sci, Biomed Res Ctr, Inst Expt Endocrinol, Dept Metab Dis Res, Bratislava, Slovakia.
   [Amiri, Ali; Ukropec, Jozef; Ukropcova, Barbara] Slovak Acad Sci, Biomed Res Ctr, Inst Expt Endocrinol, Ctr Phys Act Res, Bratislava, Slovakia.
   [Chovanec, Michal; Mego, Michal] Comenius Univ, Fac Med, Dept Oncol, Bratislava, Slovakia.
   [Chovanec, Michal; Mego, Michal] Natl Canc Inst, Bratislava, Slovakia.
   [Oliva, Viktor; Sedliak, Milan] Comenius Univ, Fac Phys Educ & Sports, Bratislava, Slovakia.
   [Ukropcova, Barbara] Comenius Univ, Fac Med, Inst Pathophysiol, Bratislava, Slovakia.
C3 Slovak Academy of Sciences; Biomedical Research Center, SAS; Institute
   of Experimental Endocrinology, SAS; Slovak Academy of Sciences;
   Institute of Experimental Endocrinology, SAS; Biomedical Research
   Center, SAS; Comenius University Bratislava; National Institute of
   Oncology (NOU); Comenius University Bratislava; Comenius University
   Bratislava
RP Chovanec, M (corresponding author), Natl Canc Inst, Bratislava, Slovakia.; Ukropcová, B (corresponding author), Slovak Acad Sci, Biomed Res Ctr, Inst Expt Endocrinol, Bratislava, Slovakia.; Chovanec, M (corresponding author), Comenius Univ, Fac Med, Dept Oncol 2, Bratislava, Slovakia.
EM Michal.chovanec@nou.sk
RI Ukropcova, Barbara/ABE-6186-2020; Ukropec, Jozef/D-5960-2018; Amiri,
   Ali/AAR-1404-2021; Sedliak, Milan/ABC-7235-2021
OI Sedliak, Milan/0000-0002-2324-154X; Chovanec,
   Michal/0000-0002-5653-2909; amiri, ali/0000-0002-8602-9052; Ukropcova,
   Barbara/0000-0002-3309-7713
FU Grant Agency of the Slovak Academy of Sciences [VEGA2/0164/20]; Slovak
   Research and Development Agency (SRDA) [APVV19-0411]; European Regional
   Development Fund - OP Integrated Infrastructure [IMTS313011V344];
   European Cooperation in Science and Technology [CA19101]; National
   Scholarship Programof Slovak Republic
FX Grant Agency of the Slovak Academy of Sciences, Grant/Award Number:
   VEGA2/0164/20; Slovak Research and Development Agency (SRDA),
   Grant/Award Number: APVV19-0411; European Regional Development Fund -OP
   Integrated Infrastructure, Grant/Award Number: IMTS313011V344; European
   Cooperation in Science and Technology, Grant/Award Number: COSTaction
   CA19101; National Scholarship Programof Slovak Republic
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NR 144
TC 14
Z9 14
U1 0
U2 16
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2047-2919
EI 2047-2927
J9 ANDROLOGY-US
JI Andrology
PD NOV
PY 2021
VL 9
IS 6
SI SI
BP 1879
EP 1892
DI 10.1111/andr.13078
EA JUL 2021
PG 14
WC Andrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA XC3FP
UT WOS:000674382400001
PM 34245663
OA Bronze
DA 2025-06-11
ER

PT J
AU Cai, DS
   Khor, S
AF Cai, Dongsheng
   Khor, Sinan
TI "Hypothalamic Microinflammation" Paradigm in Aging and Metabolic
   Diseases
SO CELL METABOLISM
LA English
DT Review
ID HIGH-FAT-DIET; ENDOPLASMIC-RETICULUM STRESS; BETA/NF-KAPPA-B; NEURAL
   STEM-CELLS; BLOOD-BRAIN-BARRIER; CONNECTS ER STRESS; INSULIN-RESISTANCE;
   ANGIOTENSIN-II; TNF-ALPHA; PROOPIOMELANOCORTIN NEURONS
AB Under conditions leading to aging and metabolic syndrome, the hypothalamus atypically undergoes proinflammatory signaling activation leading to a chronic and stable background inflammation, referred to as "hypothalamic microinflammation." Through the past decade of research, progress has been made to causally link this hypothalamic inflammation to the mechanism of aging as well as metabolic syndrome, promoting the "hypothalamic microinflammation" theory, which helps characterize the consensus of these epidemic health problems. In general, it is consistently appreciated that hypothalamic micron qammation emerges during the early stages of aging and metabolic syndrome and evolves to be multifaceted and advanced alongside disease progression, while inhibition of key inflammatory components in the hypothalamus has a broad range of effects in counteracting these disorders. Herein, focusing on aging and metabolic syndrome, this writing aims to provide an overview of and insights into the mediators, signaling components, celluar impacts, and physiological significance of this hypothalamic microinflammation.
C1 [Cai, Dongsheng; Khor, Sinan] Albert Einstein Coll Med, Dept Mol Pharmacol, Diabet Res Ctr, Inst Aging, Bronx, NY 10461 USA.
C3 Yeshiva University; Montefiore Medical Center; Albert Einstein College
   of Medicine
RP Cai, DS (corresponding author), Albert Einstein Coll Med, Dept Mol Pharmacol, Diabet Res Ctr, Inst Aging, Bronx, NY 10461 USA.
EM dongsheng.cai@einstein.yu.edu
RI Cai, Dongsheng/CAH-8271-2022
FU Einstein institutional fund; NIH [DK078750, AG031774, HL113180,
   DK099136, HL147477, DK121435]; NIH training grant T32 [AG 23475]
FX The authors sincerely thank all previous and current lab members for
   contributions to this research. The research of the authors was
   supported by Einstein institutional fund and NIH DK078750, AG031774,
   HL113180, DK099136, HL147477, and DK121435 (all to D.C.). S.K. was
   partly supported by NIH training grant T32 AG 23475.
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NR 149
TC 90
Z9 94
U1 0
U2 28
PU CELL PRESS
PI CAMBRIDGE
PA 50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA
SN 1550-4131
EI 1932-7420
J9 CELL METAB
JI Cell Metab.
PD JUL 2
PY 2019
VL 30
IS 1
BP 19
EP 35
DI 10.1016/j.cmet.2019.05.021
PG 17
WC Cell Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Endocrinology & Metabolism
GA IF9NW
UT WOS:000473420800009
PM 31269425
OA Bronze
DA 2025-06-11
ER

PT J
AU Del Ben, M
   Polimeni, L
   Carnevale, R
   Bartimoccia, S
   Nocella, C
   Baratta, F
   Loffredo, L
   Pignatelli, P
   Violi, F
   Angelico, F
AF Del Ben, Maria
   Polimeni, Licia
   Carnevale, Roberto
   Bartimoccia, Simona
   Nocella, Cristina
   Baratta, Francesco
   Loffredo, Lorenzo
   Pignatelli, Pasquale
   Violi, Francesco
   Angelico, Francesco
TI NOX2-generated oxidative stress is associated with severity of
   ultrasound liver steatosis in patients with non-alcoholic fatty liver
   disease
SO BMC GASTROENTEROLOGY
LA English
DT Article
DE Oxidative stress; Non-alcoholic fatty liver; 8-iso-PGF2 alpha; sNOX2-dp;
   Metabolic syndrome
ID MEDIATED ARTERIAL DYSFUNCTION; INSULIN-RESISTANCE; LIPID-PEROXIDATION;
   METABOLIC SYNDROME; CARDIOVASCULAR-DISEASE; DIAGNOSIS; MARKERS;
   PARAMETERS; MANAGEMENT; RISK
AB Background: Chronic oxidative stress is one of the key mechanisms responsible for disease progression in non-alcoholic fatty liver disease. However, so far, few studies reported increased circulating levels of oxidative stress markers in patients with non-alcoholic fatty liver and no study has been performed with newer markers of systemic oxidative stress. The aim was to assess the relationship between urinary 8-iso-prostaglandin F2 alpha and serum soluble NOX2-derived peptide and the severity of liver steatosis in subjects with non-alcoholic fatty liver.
   Methods: The study was performed in 264 consecutive patients referred for suspected metabolic disease. Steatosis was defined according to Hamaguchi ultrasonographic criteria. Oxidative stress was assessed by urinary 8-iso-prostaglandin F2 alpha and serum soluble NOX2-derived peptide levels.
   Results: Patients with non-alcoholic fatty liver had higher ( p < 0.001) mean values of urinary 8-iso-PGF2 alpha and of serum soluble NOX2-derived peptide, alanine aminotransferase, Cytokeratin-18 and homeostasis model of insulin resistance and lower values of serum adiponectin as compared to those without. Prevalence of metabolic syndrome and of its clinical features was significantly higher in patients with non-alcoholic fatty liver. Same findings were also observed after the exclusion of obese subjects, or subjects with diabetes or with metabolic syndrome and in those not taking statin medication. In addition, the levels of urinary 8-iso-PGF2 alpha were independent predictors of non-alcoholic fatty liver and a strong association of urinary 8-iso-PGF2 alpha and of serum soluble NOX2-derived peptide with the severity of steatosis at ultrasound was also observed.
   Conclusions: We demonstrated increased markers of oxidative stress in subjects with non-alcoholic fatty liver. Urinary 8-iso-PGF2 alpha and serum soluble NOX2-derived peptide levels were independent from obesity, diabetes and metabolic syndrome and increased with the severity of liver steatosis at ultrasound.
C1 [Del Ben, Maria; Polimeni, Licia; Carnevale, Roberto; Bartimoccia, Simona; Nocella, Cristina; Baratta, Francesco; Loffredo, Lorenzo; Pignatelli, Pasquale; Violi, Francesco] Univ Roma La Sapienza, Dept Internal Med & Med Specialties, Rome, Italy.
   [Angelico, Francesco] Univ Roma La Sapienza, Dept Publ Hlth & Infect Dis, Rome, Italy.
   [Angelico, Francesco] Policlin Umberto 1, Med Clin 1, I-00161 Rome, Italy.
C3 Sapienza University Rome; Sapienza University Rome; Sapienza University
   Rome; University Hospital Sapienza Rome
RP Angelico, F (corresponding author), Univ Roma La Sapienza, Dept Publ Hlth & Infect Dis, Rome, Italy.
EM francesco.angelico@uniroma1.it
RI Angelico, Francesco/AAB-6585-2020; Del Ben, Maria/AAE-7603-2020;
   nocella, cristina/K-2175-2016; pignatelli, pasquale/K-2116-2016; Violi,
   Francesco/K-1509-2016; Carnevale, Roberto/K-1472-2016; Bartimoccia,
   Simona/K-7873-2016; Loffredo, Lorenzo/K-4873-2016
OI Baratta, Francesco/0000-0003-1708-272X; nocella,
   cristina/0000-0003-4398-6327; pignatelli, pasquale/0000-0002-2265-7455;
   Violi, Francesco/0000-0002-6610-7068; Carnevale,
   Roberto/0000-0002-6216-9595; Bartimoccia, Simona/0000-0002-6266-3059;
   Loffredo, Lorenzo/0000-0002-6542-6235
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NR 38
TC 77
Z9 78
U1 0
U2 5
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1471-230X
J9 BMC GASTROENTEROL
JI BMC Gastroenterol.
PD APR 23
PY 2014
VL 14
AR 81
DI 10.1186/1471-230X-14-81
PG 8
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA AG7GD
UT WOS:000335585400001
PM 24758604
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Frisardi, V
   Matrone, C
   Street, ME
AF Frisardi, Vincenza
   Matrone, Carmela
   Street, Maria Elisabeth
TI Metabolic Syndrome and Autophagy: Focus on HMGB1 Protein
SO FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
LA English
DT Review
DE metabolic syndrome; autophagy; HMBG1; cellular homeostasis; insulin
   resistance; oxidative stress
ID GROUP BOX 1; OXIDATIVE STRESS; ADIPOSE-TISSUE; INSULIN; HEALTH;
   DYSFUNCTION; DISEASE; OBESE
AB Metabolic syndrome (MetS) affects the population worldwide and results from several factors such as genetic background, environment and lifestyle. In recent years, an interplay among autophagy, metabolism, and metabolic disorders has become apparent. Defects in the autophagy machinery are associated with the dysfunction of many tissues/organs regulating metabolism. Metabolic hormones and nutrients regulate, in turn, the autophagy mechanism. Autophagy is a housekeeping stress-induced degradation process that ensures cellular homeostasis. High mobility group box 1 (HMGB1) is a highly conserved nuclear protein with a nuclear and extracellular role that functions as an extracellular signaling molecule under specific conditions. Several studies have shown that HMGB1 is a critical regulator of autophagy. This mini-review focuses on the involvement of HMGB1 protein in the interplay between autophagy and MetS, emphasizing its potential role as a promising biomarker candidate for the early stage of MetS or disease's therapeutic target.
C1 [Frisardi, Vincenza] Arcispedale Santa Maria Nuova AUSL IRCCS, Clin & Nutr Lab, Dept Geriatr & NeuroRehabil, Reggio Emilia, Italy.
   [Matrone, Carmela] Univ Naples Federico II, Sch Med, Dept Neurosci, Div Pharmacol, Naples, Italy.
   [Street, Maria Elisabeth] Arcispedale Santa Maria Nuova AUSL IRCCS, Div Paediat Endocrinol & Diabetol, Paediat, Dept Mother & Child, Reggio Emilia, Italy.
C3 University of Naples Federico II
RP Frisardi, V (corresponding author), Arcispedale Santa Maria Nuova AUSL IRCCS, Clin & Nutr Lab, Dept Geriatr & NeuroRehabil, Reggio Emilia, Italy.
EM vincenza.frisardi@ausl.re.it
RI Matrone, Carmela/AAR-5405-2020; Street, Maria/B-7099-2011; frisardi,
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OI frisardi, vincenza/0000-0003-0764-7387; Matrone,
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NR 110
TC 16
Z9 16
U1 1
U2 8
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-634X
J9 FRONT CELL DEV BIOL
JI Front. Cell. Dev. Biol.
PD APR 12
PY 2021
VL 9
AR 654913
DI 10.3389/fcell.2021.654913
PG 8
WC Cell Biology; Developmental Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Developmental Biology
GA RS3TV
UT WOS:000643705400001
PM 33912566
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Rahali, D
   Dallagi, Y
   Hupkens, E
   Veegh, G
   Mc Entee, K
   El Asmi, M
   El Fazaa, S
   El Golli, N
AF Rahali, Dalila
   Dallagi, Yosra
   Hupkens, Emmeline
   Veegh, Gregory
   Mc Entee, Kathleen
   El Asmi, Monia
   El Fazaa, Saloua
   El Golli, Narges
TI Spermatogenesis and steroidogenesis disruption in a model of metabolic
   syndrome rats
SO ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
LA English
DT Article
DE Metabolic syndrome; oxidative stress; apoptosis; spermatic parameters;
   rats
ID OXIDATIVE STRESS; TESTICULAR DAMAGE; DIABETES-MELLITUS; SUPEROXIDE
   ANION; MALE OBESITY; VITAMIN-E; TESTOSTERONE; INSULIN; INFERTILITY;
   IMPROVEMENT
AB Context Metabolic syndrome (MetS) is a clustering of several physiological alterations. Objective This study was designed to evaluate the effects of MetS on rats spermatogenesis and steroidogenesis. Materials and methods We developed a MetS rodent model using high-sugar and high-fat diet. Results MetS rats showed severe disorders in sperm parameters. Interestingly, a significant increase in malondialdehyde level and a decrease in the antioxidant activities were observed. Moreover, qRT-PCR analysis showed Bax down-regulation and Bcl-2 up-regulation. A decrease in testosterone level was identified, correlated with theCYP11A1,CYP17A1and17 beta HSDtesticular marker down-regulation. Finally, MetS rats showed an up-regulation of pro-inflammatory cytokines receptorsIL-1RandIL-6R. Conclusion MetS induced severe testis toxicity in male rats. Mets markedly distorted sperm parameters, inhibited the transcription of steroidogenic enzymes and led to oxidative stress, inflammation, and alteration of Bax/Bcl-2 ratioin testicular tissues.
C1 [Rahali, Dalila; Dallagi, Yosra; El Fazaa, Saloua; El Golli, Narges] Univ Tunis El Manar, Fac Sci Tunis, Lab Neurophysiol Cellular Physiopathol & Biomol V, Tunis 2092, Tunisia.
   [Hupkens, Emmeline; Veegh, Gregory; Mc Entee, Kathleen] Univ Libre Bruxelles, Fac Med, Lab Physiol & Pharmacol, Brussels, Belgium.
   [El Asmi, Monia] La Rabta Hosp, Dept Biochem, Tunis, Tunisia.
C3 Universite de Tunis-El-Manar; Faculte des Sciences de Tunis (FST);
   Universite Libre de Bruxelles; Universite de Tunis-El-Manar; Hopital La
   Rabta
RP Rahali, D; El Golli, N (corresponding author), Univ Tunis El Manar, Fac Sci Tunis, Lab Neurophysiol Cellular Physiopathol & Biomol V, Tunis 2092, Tunisia.
EM rahali.dalila89@gmail.com; nelgolli@yahoo.fr
FU Tunisian Ministry of Higher Education and Scientific Research
FX Financial support of the Tunisian Ministry of Higher Education and
   Scientific Research is gratefully acknowledged.
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NR 71
TC 5
Z9 7
U1 0
U2 2
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1381-3455
EI 1744-4160
J9 ARCH PHYSIOL BIOCHEM
JI Arch. Physiol. Biochem.
PD JAN 2
PY 2023
VL 129
IS 1
BP 222
EP 232
DI 10.1080/13813455.2020.1812665
EA SEP 2020
PG 11
WC Biochemistry & Molecular Biology; Biophysics; Endocrinology &
   Metabolism; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Endocrinology &
   Metabolism; Physiology
GA 8N8BB
UT WOS:000566955300001
PM 32886530
DA 2025-06-11
ER

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   Braun, Joe
   Belcher, Scott M.
   Stapleton, Heather M.
TI Accumulation and Endocrine Disrupting Effects of the Flame Retardant
   Mixture Firemaster® 550 in Rats: An Exploratory Assessment
SO JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
LA English
DT Article
DE Anxiety; Cardiac Hypertrophy; Endocrine Disruptor; Flame Retardants;
   Metabolic Syndrome; Metabolism; Obesity; Obesogen; Polybrominated
   Diphenyl Ethers; Rodents
ID ELEVATED PLUS-MAZE; BISPHENOL-A; MATERNAL HYPERTHYROIDISM; METABOLIC
   SYNDROME; THYROID-HORMONES; SEWAGE-SLUDGE; INTACT MALE; IN-VIVO;
   EXPOSURE; ANXIETY
AB Firemaster (R) 550 (FM 550), a fire-retardant mixture used in foam-based products, was recently identified as a common contaminant in household dust. The chemical structures of its principle components suggest they have endocrine disrupting activity, but nothing is known about their physiological effects at environmentally relevant exposure levels. The goal of this exploratory study was to evaluate accumulation, metabolism and endocrine disrupting effects of FM 550 in rats exposed to 100 or 1000 mu g/day across gestation and lactation. FM 550 components accumulated in tissues of exposed dams and offspring and induced phenotypic hallmarks associated with metabolic syndrome in the offspring. Effects included increased serum thyroxine levels and reduced hepatic carboxylesterease activity in dams, and advanced female puberty, weight gain, male cardiac hypertrophy, and altered exploratory behaviors in offspring. Results of this study are the first to implicate FM 550 as an endocrine disruptor and an obesogen at environmentally relevant levels. #x000A9; 2012 Wiley Periodicals, Inc. J BiochemMol Toxicol 27:124-136, 2013; View this article online at wileyonlinelibrary.com. DOI 10.1002/jbt.21439
C1 [Patisaul, Heather B.; Mabrey, Natalie; McCaffrey, Katherine A.] N Carolina State Univ, Dept Biol, Raleigh, NC 27695 USA.
   [Patisaul, Heather B.] N Carolina State Univ, Keck Ctr Behav Biol, Raleigh, NC 27695 USA.
   [Roberts, Simon C.; Stapleton, Heather M.] Duke Univ, Nicholas Sch Environm, Durham, NC 27708 USA.
   [Gear, Robin B.; Belcher, Scott M.] Univ Cincinnati, Coll Med, Dept Pharmacol & Cell Biophys, Cincinnati, OH 45267 USA.
   [Braun, Joe] Brown Univ, Dept Epidemiol, Providence, RI 02912 USA.
C3 North Carolina State University; North Carolina State University; Duke
   University; University System of Ohio; University of Cincinnati; Brown
   University
RP Patisaul, HB (corresponding author), N Carolina State Univ, Dept Biol, Raleigh, NC 27695 USA.
EM hbpatisa@ncsu.edu
RI Braun, Joseph/H-8649-2014; Stapleton, Heather/AAE-7232-2019
OI Belcher, Scott/0000-0002-1196-3705
FU NIEHS [R01 ES016001];  [NIEHS R01 ES016099];  [NIEHS R01 ES015145]; 
   [RC2 ES018765]
FX The authors are grateful to Karina Todd, Sandra Losa-Ward, and Jinyan
   Cao for assisting with the tissue collection; Meghan Radford, Alana
   Sullivan, and Nicole Russ for their help with the behavioral testing;
   and the staff of the NCSU Biological Resource Facility for overseeing
   animal care and husbandry. In addition we thank Eric Kendig for his work
   on the cardiac assessments. This study was supported by research grants
   to HMS (NIEHS R01 ES016099), HBP (NIEHS, R01 ES016001), and SMB (NIEHS
   R01 ES015145, RC2 ES018765). FM 550 was provided by Chemtura.
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NR 53
TC 212
Z9 246
U1 0
U2 114
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1095-6670
EI 1099-0461
J9 J BIOCHEM MOL TOXIC
JI J. Biochem. Mol. Toxicol.
PD FEB
PY 2013
VL 27
IS 2
SI SI
BP 124
EP 136
DI 10.1002/jbt.21439
PG 13
WC Biochemistry & Molecular Biology; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Toxicology
GA 093JS
UT WOS:000315188700004
PM 23139171
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Kaprinay, B
   Lipták, B
   Slovák, L
   Svík, K
   Knezl, V
   Sotníková, R
   Gáspárová, Z
AF Kaprinay, B.
   Liptak, B.
   Slovak, L.
   Svik, K.
   Knezl, V.
   Sotnikova, R.
   Gasparova, Z.
TI Hypertriglyceridemic Rats Fed High Fat Diet as a Model of Metabolic
   Syndrome
SO PHYSIOLOGICAL RESEARCH
LA English
DT Article
DE Metabolic syndrome; Rat model; Hypertriglyceridemic rats
ID OXIDATIVE STRESS
AB People with metabolic syndrome have higher risk of cardiovascular diseases then those without. The aim of the work was to investigate whether high fat diet administered to Prague hereditary hypertriglyceridemic (HTG) rats can induce signs of metabolic syndrome (MetS). Our results showed that HTG rats fed high fat diet (HTGch) had disturbed glucose metabolism and also lipid metabolism - increased serum triacylglycerols (TAG), total cholesterol (Ch), low-density lipoprotein-Ch (LDL-Ch), and decreased high-density lipoprotein-Ch (HDL-Ch). Their livers proved markers of developing steatosis. Moreover, HTGch had increased blood pressure, yet the vascular endothelium was not significantly damaged. All these changes were accompanied with oxidative stress and tissue damage identified as increased liver concentrations of thiobarbituric acid reactive substances (TBARS) and activity of the lysosomal enzyme N-acetyl-D-glucosaminidase (NAGA). We assume that the model used may be suitable for the study of MetS with no evidence of obesity. Prolongation of the high fat diet duration might have a major impact on all parameters tested, especially on vascular endothelial function.
C1 [Kaprinay, B.; Liptak, B.; Slovak, L.; Svik, K.; Knezl, V.; Sotnikova, R.; Gasparova, Z.] Slovak Acad Sci, Inst Expt Pharmacol & Toxicol, Dubravska Cesta 9, Bratislava 84104, Slovakia.
   [Kaprinay, B.; Liptak, B.; Slovak, L.] Comenius Univ, Jessenius Fac Med, Dept Pharmacol, Martin, Slovakia.
C3 Slovak Academy of Sciences; Institute of Experimental Pharmacology &
   Toxicology, SAS; Comenius University Bratislava
RP Kaprinay, B (corresponding author), Slovak Acad Sci, Inst Expt Pharmacol & Toxicol, Dubravska Cesta 9, Bratislava 84104, Slovakia.
EM barbara.kaprinay@savba.sk
OI Gasparova, Zdenka/0000-0002-5163-7402
FU VEGA grant [2/0054/15]
FX This study was supported by the VEGA grant No. 2/0054/15. We express our
   thanks to Mrs. Dytrichova, Srnova and Vandakova for their skillful
   technical assistance. We appreciate a goodwill of Ludmila Kazdova, PhD.
   from Institute for Clinical and Experimental Medicine, Prague, Czech
   Republic, who donates us a breeding core of hereditary
   hypertriglyceridemic rats.
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NR 16
TC 20
Z9 21
U1 0
U2 8
PU ACAD SCIENCES CZECH REPUBLIC, INST PHYSIOLOGY
PI PRAGUE 4
PA VIDENSKA 1083, PRAGUE 4 142 20, CZECH REPUBLIC
SN 0862-8408
EI 1802-9973
J9 PHYSIOL RES
JI Physiol. Res.
PY 2016
VL 65
SU 4
BP S515
EP S518
DI 10.33549/physiolres.933524
PG 4
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA EH8NQ
UT WOS:000392029200012
PM 28006934
OA gold
DA 2025-06-11
ER

PT J
AU Zhu, YJ
   Bing, J
   Zheng, LL
   Hao, PK
   Teng, XY
   Wan, LX
AF Zhu, Yingjie
   Bing, Jia
   Zheng, Lili
   Hao, Pengkai
   Teng, Xiaoyu
   Wan, Lixin
TI The association between composite dietary antioxidant index and the
   metabolic syndrome: NHANES 2007-2018
SO JOURNAL OF FUNCTIONAL FOODS
LA English
DT Article
DE Metabolic syndrome (MetS); Composite dietary antioxidant index (CDAI);
   NHANES; Oxidative stress
ID PHYSICAL-ACTIVITY; OXIDATIVE STRESS; PATHOPHYSIOLOGY; INFLAMMATION; RISK
AB Background: Metabolic syndrome (MetS) is a pathological condition. Oxidative stress is intricately linked to MetS, and may be reflected by composite dietary antioxidant index (CDAI). We aimed to explore the association between CDAI and MetS. Methods: 12,580 participants aged over 20 years were involved. The relationship between CDAI and MetS was examined through binary logistic regression. Subgroup analysis and interaction tests were employed. Results: The negative association between high scores on CDAI and the prevalence of MetS were found. Notably, an interaction between CDAI and physical activity in relation to MetS was observed. High scores on CDAI were significantly and negatively linked to MetS prevalence within the active physical activity groups. Conclusion: Higher scores on CDAI was significantly associated with lower odds of MetS. An interaction existed between CDAI and physical activity. It is advisable for individuals to enhance their personal scores on CDAI.
C1 [Zhu, Yingjie] Jilin Prov Reprod Hlth Hosp, Jilin Prov Inst Populat Life Sci & Technol, Changchun 130000, Peoples R China.
   [Bing, Jia; Zheng, Lili; Hao, Pengkai; Teng, Xiaoyu; Wan, Lixin] Jilin Obstet Qual Control Ctr, Jilin Maternal & Child Hlth Hosp, Changchun 130000, Peoples R China.
RP Wan, LX (corresponding author), Jilin Obstet Qual Control Ctr, Jilin Maternal & Child Hlth Hosp, Changchun 130000, Peoples R China.
EM wanlixin0086@163.com
RI Wan, Lixin/F-2124-2011; Zheng, Lili/LJK-3060-2024
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NR 45
TC 1
Z9 1
U1 6
U2 16
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1756-4646
EI 2214-9414
J9 J FUNCT FOODS
JI J. Funct. Food.
PD MAY
PY 2024
VL 116
AR 106200
DI 10.1016/j.jff.2024.106200
EA APR 2024
PG 7
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA SL0E7
UT WOS:001234482200001
OA gold
DA 2025-06-11
ER

PT J
AU Dasilva, G
   Pazos, M
   García-Egido, E
   Pérez-Jiménez, J
   Torres, JL
   Giralt, M
   Nogués, MR
   Medina, I
AF Dasilva, Gabriel
   Pazos, Manuel
   Garcia-Egido, Eduardo
   Perez-Jimenez, Jara
   Lluis Torres, Josep
   Giralt, Montserrat
   Nogues, Maria-Rosa
   Medina, Isabel
TI Lipidomics to analyze the influence of diets with different EPA: DHA
   ratios in the progression of Metabolic Syndrome using SHROB rats as a
   model
SO FOOD CHEMISTRY
LA English
DT Article
DE Lipid mediators; EPA; DHA; Metabolic Syndrome; SHROB; Inflammation;
   Oxidative stress
ID POLYUNSATURATED FATTY-ACIDS; FISH-OIL; SUPPLEMENTATION; LIPIDS;
   TRANSCRIPTION; INFLAMMATION; EXTRACTION; OXIDATION; ENZYMES; OBESITY
AB The role of specific proportions of x-3 EPA and DHA, in the modulation of inflammation and oxidative stress markers associated to the progression of Metabolic Syndrome was investigated. Potential inflammatory eicosanoids and docosanoids were discussed together to biomarkers of CVD, obesity, inflammation and oxidative stress in an animal model of metabolic disorders. Results evidenced a noteworthy health effect of 1: 1 and 2: 1 EPA: DHA proportions over 1: 2 EPA: DHA based diets through a down-regulation in the production of strong pro-inflammatory x-6 eicosanoids, a decrement of biomarkers of oxidative stress, and a modulation of fatty acid desaturase activities and plasma and membrane PUFAs towards greater anti-inflammatory profiles. Outcomes contribute to the general knowledge on the health benefits of marine lipids and their role on the progress of MetS, inflammation and oxidative stress. Results shed light on controversial protective mechanisms of EPA and DHA to better design dietary interventions aimed at reducing MetS. (C) 2016 Elsevier Ltd. All rights reserved.
C1 [Dasilva, Gabriel; Pazos, Manuel; Garcia-Egido, Eduardo; Medina, Isabel] Consejo Super Invest Cient IIM CSIC, Inst Invest Marinas, E-36208 Vigo, Galicia, Spain.
   [Dasilva, Gabriel] Univ Santiago de Compostela, Dept Analyt Chem Nutr & Bromatol, E-15782 Santiago De Compostela, Galicia, Spain.
   [Dasilva, Gabriel] Univ Santiago de Compostela, Res Inst Food Anal IIAA, E-15782 Santiago De Compostela, Galicia, Spain.
   [Perez-Jimenez, Jara; Lluis Torres, Josep] Inst Quim Avanzada Catalunya IQAC CSIC, Jordi Girona 18-26, E-08034 Barcelona, Spain.
   [Giralt, Montserrat; Nogues, Maria-Rosa] Univ Rovira & Virgili, Unidad Farmacol, Fac Med, St Llorenc 21, E-43201 Reus, Spain.
C3 Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Instituto
   de Investigaciones Marinas (IIM); Universidade de Santiago de
   Compostela; Universidade de Santiago de Compostela; Consejo Superior de
   Investigaciones Cientificas (CSIC); CSIC - Centro de Investigacion y
   Desarrollo Pascual Vila (CID-CSIC); CSIC - Instituto de Quimica Avanzada
   de Cataluna (IQAC); Universitat Rovira i Virgili
RP Dasilva, G (corresponding author), Consejo Super Invest Cient IIM CSIC, Inst Invest Marinas, E-36208 Vigo, Galicia, Spain.
EM gabrieldasilvaalonso@gmail.com
RI MEDINA, ISABEL/AAL-4012-2021; Perez-Jimenez, Jara/B-3989-2009; Nogués,
   M./ABH-5645-2020; Pazos, Manuel/N-5007-2014; Torres, Josep/N-7256-2013
OI Pazos, Manuel/0000-0003-1571-5730; MEDINA, ISABEL/0000-0002-1854-3359;
   Torres, Josep/0000-0002-5072-8265; dasilva, gabriel/0000-0002-1098-7262;
   Perez-Jimenez, Jara/0000-0002-2811-4558
FU Spanish Ministerio de Economia y Competitividad [AGL2009-12374-C3-1,
   AGL2009-12374-C3-2, AGL2009-12374-C3-3, AGL2013-49079-C2-1,2-R]; Consejo
   Superior de Investigaciones Cientificas (CSIC); University of Santiago
   de Compostela (USC); European Social Fund; ISCIII [CD09/00068]
FX This work was supported by the Spanish Ministerio de Economia y
   Competitividad (AGL2009-12374-C3-1, -2, and -3, and
   AGL2013-49079-C2-1,2-R). The Consejo Superior de Investigaciones
   Cientificas (CSIC) and the University of Santiago de Compostela (USC)
   are gratefully acknowledged for the doctoral fellowship to Gabriel
   Dasilva. Xunta de Galicia and European Social Fund are also thankfully
   recognized for the financial support of the postdoctoral contracts to M.
   P and E.G.-E., and ISCIII for the postdoctoral contract "Sara Borrell"
   to J.P.-J. (CD09/00068).
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NR 36
TC 34
Z9 37
U1 0
U2 87
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0308-8146
EI 1873-7072
J9 FOOD CHEM
JI Food Chem.
PD AUG 15
PY 2016
VL 205
BP 196
EP 203
DI 10.1016/j.foodchem.2016.03.020
PG 8
WC Chemistry, Applied; Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Food Science & Technology; Nutrition & Dietetics
GA DG8SX
UT WOS:000372355000026
PM 27006231
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Medina-Contreras, JML
   Villalobos-Molina, R
   Zarain-Herzberg, A
   Balderas-Villalobos, J
AF Medina-Contreras, J. M. L.
   Villalobos-Molina, R.
   Zarain-Herzberg, A.
   Balderas-Villalobos, J.
TI Ovariectomized rodents as a menopausal metabolic syndrome model. A
   minireview
SO MOLECULAR AND CELLULAR BIOCHEMISTRY
LA English
DT Review
DE Ovariectomy; Menopause model; Metabolic syndrome; Hypoestrogenism
ID HIGH-FAT-DIET; INSULIN-RESISTANCE; OXIDATIVE STRESS; SKELETAL-MUSCLE;
   FEMALE RATS; POSTMENOPAUSAL WOMEN; HEPATIC STEATOSIS; OVARIAN-FUNCTION;
   BODY-COMPOSITION; ADIPOSE-TISSUE
AB Bilateral ovariectomy is the best characterized and the most reported animal model of human menopause. Ovariectomized rodents develop insulin resistance (IR) and visceral obesity, the main risk factors in the pathophysiology of metabolic syndrome (MS). These alterations are a consequence of hypoestrogenic status, which produces an augment of visceral fat, high testosterone levels (hyperandrogenism), as well as inflammation, oxidative stress, and metabolic complications, such as dyslipidemia, hepatic steatosis, and endothelial dysfunction, among others. Clinical trials have reported that menopause per se increases the severity and incidence of MS, and causes the highest mortality due to cardiovascular disease in women. Despite all the evidence, there are no reports that clarify the influence of estrogenic deficiency as a cause of MS. In this review, we provide evidence that ovariectomized rodents can be used as a menopausal metabolic syndrome model for evaluating and discovering new, safe, and effective therapeutic approaches in the treatment of cardiometabolic complications associated to MS during menopause.
C1 [Medina-Contreras, J. M. L.; Villalobos-Molina, R.; Zarain-Herzberg, A.; Balderas-Villalobos, J.] Univ Nacl Autonoma Mexico, Dept Bioquim, Fac Med, Lab Biol Mol, 2Do Piso,Torre Invest, Mexico City, DF, Mexico.
   [Medina-Contreras, J. M. L.; Villalobos-Molina, R.] Univ Nacl Autonoma Mexico, Unidad Biomed, Fac Estudios Super Iztacala, Tlalnepantla, Mexico.
C3 Universidad Nacional Autonoma de Mexico; Universidad Nacional Autonoma
   de Mexico
RP Balderas-Villalobos, J (corresponding author), Univ Nacl Autonoma Mexico, Dept Bioquim, Fac Med, Lab Biol Mol, 2Do Piso,Torre Invest, Mexico City, DF, Mexico.
EM jimygosth@hotmail.com
OI Medina Contreras, Juana Maria de Lourdes/0000-0001-8936-7703; Balderas
   Villalobos, Jaime/0000-0002-4997-2703
FU Consejo Nacional de Ciencia y Tecnologia (CONACYT); PAPIIT, DGAPA, UNAM
   [IN227116]
FX JMLMC and JBV were postdoctoral fellows supported by Consejo Nacional de
   Ciencia y Tecnologia (CONACYT). Authors thank PAPIIT, DGAPA, UNAM for
   Grant IN227116.
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NR 118
TC 50
Z9 56
U1 0
U2 15
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0300-8177
EI 1573-4919
J9 MOL CELL BIOCHEM
JI Mol. Cell. Biochem.
PD DEC
PY 2020
VL 475
IS 1-2
BP 261
EP 276
DI 10.1007/s11010-020-03879-4
EA AUG 2020
PG 16
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA OL7TE
UT WOS:000565601500001
PM 32852713
DA 2025-06-11
ER

PT J
AU Li, YN
   Buys, N
   Ferguson, S
   Li, ZY
   Shi, YC
   Li, L
   Sun, J
AF Li, Yanni
   Buys, Nicholas
   Ferguson, Samantha
   Li, Zhiyong
   Shi, Yan-Chuan
   Li, Li
   Sun, Jing
TI The evaluation of cognitive-behavioral therapy-based intervention on
   type 2 diabetes patients with comorbid metabolic syndrome: a randomized
   controlled trial
SO DIABETOLOGY & METABOLIC SYNDROME
LA English
DT Article
DE Type 2 diabetes; Metabolic Syndrome; Cognitive Behavior Therapy; Health
   outcomes
ID SELF-MANAGEMENT; DEPRESSION; PREVALENCE; MELLITUS; ANXIETY; ADULTS;
   METAANALYSIS; ADHERENCE; CHINA
AB Background Cognitive behavior therapy (CBT) has been applied in intervention research in diabetes patients with satisfying results. However, there was no research on type 2 diabetes (T2DM) patients with comorbidities. This study aimed to investigate the effectiveness of CBT on psychological variables, behavior variables, quality of life, sleep quality, and physical variables among adult T2DM patients with comorbid metabolic syndrome (MS).
   Methods 281 patients aged 18-75 years were recruited from Ningbo First Hospital in China from October 2021 to March 2022. Patients were randomized to the intervention group (IG, N = 148) or control group (CG, N = 133). Patients in the IG received 12 CBT-based sessions during a six-month intervention time. Patients in the CG received the usual care only. Univariate General Linear Model was used to analyze the effect of CBT-based interventions. The analysis was conducted by SPSS Version 28.
   Results Results indicated that CBT-based intervention was superior in the following aspects: relieving depression symptoms: IG (4.11 +/- 4.35 vs. 1.99 +/- 2.12), CG (3.40 +/- 3.26 vs. 2.32 +/- 1.88), interaction effect (F = 4.074, P = 0.044); enhancing diabetes self-care behaviors: IG (26.79 +/- 12.18 vs. 37.49 +/- 10.83), CG (25.82 +/- 13.71 vs. 31.96 +/- 11.72), interaction effect (F = 5.242, P = 0.022); promoting the efficacy of CBT: IG (47.45 +/- 6.83 vs. 50.76 +/- 4.98), CG (46.74 +/- 6.94 vs. 47.87 +/- 5.11), interaction effect (F = 5.198, P = 0.023); improving subjective sleep quality: IG (0.93 +/- 0.68 vs. 0.69 +/- 0.63), CG (1.03 +/- 0.72 vs. 1.01 +/- 0.68), interaction effect (F = 3.927, P = 0.048).
   Conclusions The CBT-based intervention was beneficial in improving depression symptoms, diabetes self-care behaviors, the efficacy of CBT, and sleep quality in T2DM patients with comorbid MS. The downtrend of body mass index, systolic blood pressure, diastolic pressure, and glycated hemoglobin was larger in the intervention group but not to a significant level.
C1 [Li, Li] Ningbo First Hosp, Dept Endocrinol & Metab, Ningbo 315010, Zhejiang, Peoples R China.
   [Li, Yanni; Sun, Jing] Griffith Univ, Sch Med & Dent, Q4222, Gold Coast, Qld, Australia.
   [Buys, Nicholas; Ferguson, Samantha] Griffith Univ, Griffith Hlth, Gold Coast, Qld, Australia.
   [Sun, Jing] Griffith Univ, Inst Integrated Intelligence & Syst, Gold Coast, Qld, Australia.
   [Li, Zhiyong] Queensland Univ Technol, Sch Mech Med & Proc Engn, Brisbane, Qld, Australia.
   [Shi, Yan-Chuan] Univ New South Wales, Garvan Inst Med Res, Fac Med & Hlth, Neuroendocrinol Grp, 384 Victoria St, Darlinghurst, Australia.
   [Sun, Jing] Griffith Univ, Menzies Hlth Inst Queensland, Gold Coast, Australia.
C3 Ningbo University; Griffith University; Griffith University - Gold Coast
   Campus; Griffith University; Griffith University - Gold Coast Campus;
   Griffith University; Griffith University - Gold Coast Campus; Queensland
   University of Technology (QUT); Garvan Institute of Medical Research;
   University of New South Wales Sydney; Menzies Health Institute
   Queensland; Griffith University; Griffith University - Gold Coast Campus
RP Li, L (corresponding author), Ningbo First Hosp, Dept Endocrinol & Metab, Ningbo 315010, Zhejiang, Peoples R China.; Sun, J (corresponding author), Griffith Univ, Sch Med & Dent, Q4222, Gold Coast, Qld, Australia.; Sun, J (corresponding author), Griffith Univ, Inst Integrated Intelligence & Syst, Gold Coast, Qld, Australia.; Sun, J (corresponding author), Griffith Univ, Menzies Hlth Inst Queensland, Gold Coast, Australia.
EM lilyningbo@163.com; j.sun@griffith.edu.au
RI Shi, Yanchuan/H-5608-2012; Buys, Nicholas/AAT-3925-2020; LI,
   ZHIYONG/AAE-3158-2019; Sun, Jing/AAS-1582-2020; Li, Zhi-Yong/G-9701-2011
OI Sun, Jing/0000-0002-0097-2438; Li, Li/0000-0001-6301-3544; Li,
   Zhi-Yong/0000-0002-6814-9165
FU Griffith University International Postgraduate Research Scholarship
   (GUIPRS) from Griffith University
FX This work was supported by the Griffith University International
   Postgraduate Research Scholarship (GUIPRS) from Griffith University.
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NR 60
TC 5
Z9 5
U1 0
U2 7
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1758-5996
J9 DIABETOL METAB SYNDR
JI Diabetol. Metab. Syndr.
PD JUL 17
PY 2023
VL 15
IS 1
AR 158
DI 10.1186/s13098-023-01100-2
PG 15
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA M8GE5
UT WOS:001032537000002
PM 37461057
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Aghadavod, E
   Soleimani, A
   Hamidi, G
   Keneshlou, F
   Heidari, A
   Asemi, Z
AF Aghadavod, Esmat
   Soleimani, Alireza
   Hamidi, Gholamali
   Keneshlou, Fariba
   Heidari, Akbar
   Asemi, Zatollah
TI Effects of High-dose Vitamin E Supplementation on Markers of
   Cardiometabolic Risk and Oxidative Stress in Patients with Diabetic
   Nephropathy A Randomized Double-blinded Controlled Trial
SO IRANIAN JOURNAL OF KIDNEY DISEASES
LA English
DT Article
DE vitamin E; diabetic nephropathy; lipids; oxidative stress
ID ALPHA-TOCOPHEROL SUPPLEMENTATION; LOW-DENSITY-LIPOPROTEIN; LIPID
   PROFILES; HEMODIALYSIS-PATIENTS; KIDNEY-DISEASE; EXPRESSION; PROTEIN;
   RATS
AB Introduction. Patients with diabetic nephropathy (DN) may benefit from vitamin E's antilipid and antioxidant activities. This study aimed to evaluate the effects of high-dose vitamin E supplementation on markers of cardiometabolic risk and oxidative stress in patients with DN.
   Materials and Methods. This randomized controlled trial was carried out on 54 patients with DN that were randomly divided into 2 groups to receive vitamin E supplement (800 IU/d) or placebo for 12 weeks. Fasting blood samples were obtained at baseline and after the 12-week intervention to determine markers of cardiometabolic risk and oxidative stress.
   Results. Vitamin E supplementation, compared with the placebo, resulted in a significant reduction in serum total cholesterol (-14.3 +/- 29.9 mg/dL versus -0.8 +/- 13.1 mg/L, P = .03), low-density lipoprotein cholesterol (-16.4 +/- 28.5 mg/dL versus 0.1 +/- 17.2 mg/L, P = .01), and ratio of total cholesterol to high-density lipoprotein cholesterol ratio (-0.5 +/- 0.7 versus 0.1 +/- 0.5, P = .001), and a significant elevation in vitamin E levels (39.7 +/- 12.4 runol/mL versus -0.5 +/- 1.3 nmol/mL, P < .001) and high-density lipoprotein cholesterol levels (1.4 +/- 3.7 versus -2.1 +/- 5.1 mg/L, P = .006). It also resulted in a significant elevation in plasma glutathione levels.
   Conclusions. Our study demonstrated that high-dose vitamin E supplementation for 12 weeks had favorable effects on lipid profile and glutathione levels of patients with DN, except for triglycerides, very low-density lipoprotein cholesterol, nitric oxide, and total antioxidant capacity levels.
C1 [Aghadavod, Esmat; Heidari, Akbar; Asemi, Zatollah] Kashan Univ Med Sci, Res Ctr Biochem & Nutr Metab Dis, Kashan, Iran.
   [Soleimani, Alireza] Kashan Univ Med Sci, Dept Internal Med, Kashan, Iran.
   [Hamidi, Gholamali] Kashan Univ Med Sci, Physiol Res Ctr, Kashan, Iran.
   [Keneshlou, Fariba] Alborz Univ Med Sci, Sch Med, Dept Urol, Karaj, Iran.
C3 Alborz University of Medical Sciences
RP Asemi, Z (corresponding author), Kashan Univ Med Sci, Res Ctr Biochem & Nutr Metab Dis, Kashan, Iran.
EM asemi_r@yahoo.com
RI asemi, zatollah/J-2677-2018; heidari, Akbar/AAG-7775-2021; Aghadavod,
   Esmat/I-7736-2017
OI Aghadavod, Esmat/0000-0001-9456-9238
FU Kashan University of Medical Sciences, Iran
FX The present study was supported by a grant from the Vice-chancellor for
   Research, Kashan University of Medical Sciences, Iran.
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NR 32
TC 24
Z9 24
U1 0
U2 6
PU IRANIAN SOC NEPHROLGY
PI TEHRAN
PA APT 12, NO 63, SHAHEED TOUSI ST, DR GHARIB ST, KESHAVARZ BLVD, TEHRAN,
   1419783311, IRAN
SN 1735-8582
EI 1735-8604
J9 IRAN J KIDNEY DIS
JI Iran. J. Kidney Dis.
PD MAY
PY 2018
VL 12
IS 3
BP 156
EP 162
PG 7
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA GJ3AZ
UT WOS:000435148300004
PM 29891745
DA 2025-06-11
ER

PT J
AU Ferreira, DJS
   Sellitti, DF
   Lagranha, CJ
AF Ferreira, D. J. S.
   Sellitti, D. F.
   Lagranha, C. J.
TI Protein undernutrition during development and oxidative impairment in
   the central nervous system (CNS): potential factors in the occurrence of
   metabolic syndrome and CNS disease
SO JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE
LA English
DT Article; Proceedings Paper
CT Scientific Meeting on Australia and New Zealand Developmental Origins of
   Health and Disease (ANZ DOHaD)
CY 2015
CL Melbourne, AUSTRALIA
DE developmental stage; mental health; illness; metabolic syndrome;
   molecular; cellular; outcome; system
ID OXYGEN SPECIES ENZYMES; REACTIVE OXYGEN; SUPEROXIDE-PRODUCTION;
   LIPID-PEROXIDATION; MITOCHONDRIAL DYSFUNCTION; FREE-RADICALS;
   NITRIC-OXIDE; COMPLEX-I; ENDOTHELIAL DYSFUNCTION; DEHYDROGENASE COMPLEX
AB Mitochondria play a regulatory role in several essential cell processes including cell metabolism, calcium balance and cell viability. In recent years, it has been postulated that mitochondria participate in the pathogenesis of a number of chronic diseases, including central nervous system disorders. Thus, the concept of mitochondrial function now extends far beyond the common view of this organelle as the powerhouse' of the cell to a new appreciation of the mitochondrion as a transducer of early metabolic insult into chronic disease in later life. In this review, we have attempted to describe some of the associations between nutritional status and mitochondrial function (and dysfunction) during embryonic development with the occurrence of neural oxidative imbalance and neurogenic disease in adulthood.
C1 [Ferreira, D. J. S.; Lagranha, C. J.] Univ Fed Pernambuco, Neuropsychiat & Behav Sci Grad Program, Vitoria De Santo Antao, Brazil.
   [Sellitti, D. F.] Uniformed Serv Univ Hlth Sci, Dept Med, Room A3060, Bethesda, MD 20814 USA.
   [Lagranha, C. J.] Univ Fed Pernambuco, Lab Biochem & Exercise Biochem, Dept Phys Educ & Sports Sci, Vitoria De Santo Antao, Brazil.
C3 Universidade Federal de Pernambuco; Uniformed Services University of the
   Health Sciences - USA; Universidade Federal de Pernambuco
RP Lagranha, CJ (corresponding author), Rua Alto Reservatorio,S-N, BR-55608680 Bela Vista, Vitoria De Sant, Brazil.
EM lagranha@hotmail.com
OI Ferreira, Diorginis/0000-0003-4303-6284; Lagranha,
   Claudia/0000-0001-6883-9476
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NR 148
TC 6
Z9 6
U1 0
U2 3
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 2040-1744
EI 2040-1752
J9 J DEV ORIG HLTH DIS
JI J. Dev. Orig. Health Dis.
PD OCT
PY 2016
VL 7
IS 5
BP 513
EP 524
DI 10.1017/S2040174416000246
PG 12
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Public, Environmental & Occupational Health
GA DZ1VZ
UT WOS:000385631000010
PM 27270104
DA 2025-06-11
ER

PT J
AU Robson, EM
   Costa, S
   Hamer, M
   Johnson, W
AF Robson, E. M.
   Costa, S.
   Hamer, M.
   Johnson, W.
TI Life course factors associated with metabolically healthy obesity: a
   protocol for the systematic review of longitudinal studies
SO SYSTEMATIC REVIEWS
LA English
DT Review
DE Metabolically healthy obesity; Metabolic syndrome; Obesity; Life course;
   Longitudinal study; Body size; Body composition; Puberty; Lifestyle
   behaviours; Psychosocial stress
ID NORMAL-WEIGHT; RISK; PHENOTYPES; PREVALENCE; OVERWEIGHT; STABILITY;
   TRENDS
AB Background: There is heterogeneity among obese individuals, as some appear to have healthier metabolic profiles and decreased health risks. These individuals are defined as metabolically healthy obese (MHO), whilst those with unhealthy metabolic profiles are defined as metabolically unhealthy obese (MUO). To date, most research on MHO has been cross-sectional or focused on disease prognosis. However, longitudinal studies are required to provide greater insight into the life course factors that contribute to the development of MHO. This study aims to systematically review longitudinal studies investigating the association between life course exposures and future MHO status.
   Methods: Electronic databases (MEDLINE, SCOPUS, and Web of Science) will be searched using a trialled search strategy. Studies will be included following a double-screening process according to inclusion criteria to assess eligibility. Studies eligible for inclusion will include those that have a longitudinal observational design where a life course exposure occurred or was measured at least 1 year before the outcome, investigate a human study population, are published in English after 1956, and investigate the association between >= 1 life course exposure and >= 1 outcome that reflects a measure of cardiometabolic resilience to obesity. Accepted life course exposures will include body size, body composition, pubertal development, smoking, diet, physical activity, sedentary behaviour, and psychosocial stress. The primary measure of cardiometabolic resilience to obesity will be MHO as an outcome (at follow-up). Studies investigating the development of cardiometabolic risk factors in an obese group without specifying MHO will also be accepted, such as the development of the metabolic syndrome (MetS) in an obese group. Key results of included studies will be tabulated, and a narrative synthesis will be conducted.
   Discussion: This will be the first systematic review to summarise the literature on the life course correlates of MHO. Importantly, it may highlight which modifiable lifestyle factors could be targeted to delay the onset of cardiometabolic complications among the obese.
C1 [Robson, E. M.; Hamer, M.; Johnson, W.] Loughborough Univ, Sch Sport Exercise & Hlth Sci, Loughborough LE11 3TU, Leics, England.
   [Costa, S.] Univ Cambridge, Sch Clin Med, MRC Epidemiol Unit, UKCRC Ctr Diet & Act Res CEDAR, Cambridge CB2 0QQ, England.
C3 Loughborough University; University of Cambridge
RP Robson, EM (corresponding author), Loughborough Univ, Sch Sport Exercise & Hlth Sci, Loughborough LE11 3TU, Leics, England.
EM E.M.Robson2@lboro.ac.uk
RI ; Hamer, Mark/C-1602-2008
OI Costa, Silvia/0000-0002-7774-6711; Hamer, Mark/0000-0002-8726-7992
FU Medical Research Council (MRC) New Investigator Research Grant
   [MR/P023347/1]; National Institute for Health Research (NIHR) Leicester
   Biomedical Research Centre; MRC [MR/P023347/1] Funding Source: UKRI
FX WJ is supported by a Medical Research Council (MRC) New Investigator
   Research Grant (MR/P023347/1). MH and WJ acknowledge the support from
   the National Institute for Health Research (NIHR) Leicester Biomedical
   Research Centre, which is a partnership between University Hospitals of
   Leicester NHS Trust, Loughborough University, and the University of
   Leicester.
CR [Anonymous], ANN N Y ACAD SCI
   [Anonymous], J OBES
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NR 25
TC 8
Z9 8
U1 0
U2 7
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 2046-4053
J9 SYST REV-LONDON
JI Syst. Rev.
PD MAR 27
PY 2018
VL 7
AR 50
DI 10.1186/s13643-018-0713-x
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA HB2SF
UT WOS:000450892000002
PM 29587826
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Shively, CA
   Register, TC
   Clarkson, TB
AF Shively, Carol A.
   Register, Thomas C.
   Clarkson, Thomas B.
TI Social Stress, Visceral Obesity, and Coronary Artery Atherosclerosis:
   Product of a Primate Adaptation
SO AMERICAN JOURNAL OF PRIMATOLOGY
LA English
DT Review
DE coronary artery atherosclerosis; visceral obesity; metabolic syndrome;
   social stress; cortisol
ID FEMALE CYNOMOLGUS MONKEYS; BODY-FAT DISTRIBUTION; INSULIN-RESISTANCE;
   METABOLIC SYNDROME; DIABETES-MELLITUS; ADIPOSE-TISSUE; RISK-FACTORS;
   ENDOTHELIAL DYSFUNCTION; CARDIOVASCULAR-DISEASE; BONNET MACAQUES
AB Abdominal obesity is prevalent and often accompanied by an array of metabolic perturbations including elevated blood pressure, dyslipidemia, impaired glucose tolerance or insulin resistance, a prothrombotic state, and a proinflammatory state, together referred to as the metabolic syndrome. The metabolic syndrome greatly increases coronary heart disease (CHD) risk. Social stress also increases CHD although the mechanisms through which this occurs are not completely understood. Chronic stress may result in sustained glucocorticoid production, which is thought to promote visceral obesity. Thus, one hypothesis is that social stress may cause visceral fat deposition and the metabolic syndrome, which, in turn increases CHD. CHD is caused by coronary artery atherosclerosis (CAA) and its sequelae. Cynomolgus monkeys (Macaca fascicularis) are a well-established models of CAA. Social subordination may be stressful to cynomolgus monkeys and result in hypercortisolemia and exacerbated CAA in females. Herein is reviewed a body of literature which suggests that social stress increases visceral fat deposition in cynomolgus monkeys, that subordinate females are more likely than dominants to have visceral obesity, that females with visceral obesity have behavioral and physiological characteristics consistent with a stressed state, and that females with high ratios of visceral to subcutaneous abdominal fat develop more CAA. While these relationships have been most extensively studied in cynomolgus macaques, obesity-related metabolic disturbances are also observed in other primate species. Taken together, these observations support the view that the current obesity epidemic is the result of a primate adaptation involving the coevolution with encephalization of elaborate physiological systems to protect against starvation and defend stored body fat in order to feed a large and metabolically demanding brain. Social stress may be engaging these same physiological systems, increasing the visceral deposition of fat and its sequelae, which increase CHD risk. Am. J. Primatol. 71:742-751, 2009. (C) 2009 Wiley-Liss, Inc.
C1 [Shively, Carol A.; Register, Thomas C.; Clarkson, Thomas B.] Wake Forest Univ, Bowman Gray Sch Med, Comparat Med Sect, Dept Pathol,Primate Ctr, Winston Salem, NC 27157 USA.
C3 Wake Forest University; Wake Forest Baptist Medical Center
RP Shively, CA (corresponding author), Wake Forest Univ, Bowman Gray Sch Med, Comparat Med Sect, Dept Pathol,Primate Ctr, 300 S Hawthorne Rd, Winston Salem, NC 27157 USA.
EM cshively@wfubmc.edu
RI Shively, Carol/L-2921-2019; Register, Thomas/KLY-9188-2024
OI Register, Thomas/0000-0002-4078-0166
FU Wake Forest University Claude D. Pepper Older Americans Independence
   Center [P30-AG21332]; National Heart, Lung, and Blood Institute,
   National Institutes of Health [HL-39789, HL087103]; John D. and
   Catherine T. MacArthur Foundation
FX Wake Forest University Claude D. Pepper Older Americans Independence
   Center; Contract grant number: P30-AG21332; Contract grant sponsor:
   National Heart, Lung, and Blood Institute, National Institutes of
   Health; Contract grant numbers: HL-39789; HL087103; Contract grant
   sponsor: John D. and Catherine T. MacArthur Foundation.
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NR 56
TC 98
Z9 104
U1 1
U2 23
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0275-2565
EI 1098-2345
J9 AM J PRIMATOL
JI Am. J. Primatol.
PD SEP
PY 2009
VL 71
IS 9
SI SI
BP 742
EP 751
DI 10.1002/ajp.20706
PG 10
WC Zoology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Zoology
GA 488SH
UT WOS:000269369600005
PM 19452515
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Flores, MEJ
AF Jaramillo Flores, Maria Eugenia
TI Cocoa Flavanols: Natural Agents with Attenuating Effects on Metabolic
   Syndrome Risk Factors
SO NUTRIENTS
LA English
DT Review
DE cocoa; bioactive compounds; flavanols bioavailability; anti-inflammatory
   properties; metabolic syndrome; oxidative stress
ID THEOBROMA-CACAO L.; OXIDATIVE STRESS; BLOOD-PRESSURE; ENDOTHELIAL-CELLS;
   SMALL-INTESTINE; IN-VITRO; OBESITY; (-)-EPICATECHIN; PROCYANIDINS;
   INFLAMMATION
AB The interest in cacao flavanols is still growing, as bioactive compounds with potential benefits in the prevention of chronic diseases associated with inflammation, oxidative stress and metabolic disorders. Several analytical methodologies support that the flavanols in cacao-derived products can be absorbed, have bioactive properties, and thus can be responsible for their beneficial effects on human health. However, it must be considered that their biological actions and underlying molecular mechanisms will depend on the concentrations achieved in their target tissues. Based on the antioxidant properties of cacao flavanols, this review focuses on recent advances in research regarding their potential to improve metabolic syndrome risk factors. Additionally, it has included other secondary plant metabolites that have been investigated for their protective effects against metabolic syndrome. Studies using laboratory animals or human subjects represent strong available evidence for biological effects of cacao flavanols. Nevertheless, in vitro studies are also included to provide an overview of these phytochemical mechanisms of action. Further studies are needed to determine if the main cacao flavanols or their metabolites are responsible for the observed health benefits and which are their precise molecular mechanisms.
C1 [Jaramillo Flores, Maria Eugenia] Inst Politecn Nacl, Escuela Nacl Ciencias Biol, Dept Ingn Bioquim, Unidad Profes Adolfo Lopez Mateos, Wilfrido Massieu S-N Esq, Mexico City 07738, DF, Mexico.
C3 Instituto Politecnico Nacional - Mexico
RP Flores, MEJ (corresponding author), Inst Politecn Nacl, Escuela Nacl Ciencias Biol, Dept Ingn Bioquim, Unidad Profes Adolfo Lopez Mateos, Wilfrido Massieu S-N Esq, Mexico City 07738, DF, Mexico.
EM Jaramillo_flores@hotmail.com
OI JARAMILLO FLORES, MARIA EUGENIA/0000-0002-0351-5339
FU  [SIP-IPN 201905333];  [CONACYT-CB-2013-01];  [220732-I010/532/2014]
FX This work was financially supported through the project SIP-IPN
   201905333; CONACYT-CB-2013-01 No. 220732-I010/532/2014.
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NR 89
TC 39
Z9 41
U1 3
U2 24
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 2072-6643
J9 NUTRIENTS
JI Nutrients
PD APR
PY 2019
VL 11
IS 4
AR 751
DI 10.3390/nu11040751
PG 32
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA HX9SX
UT WOS:000467749800044
PM 30935075
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Arnoldussen, IAC
   Witkamp, RF
AF Arnoldussen, Ilse A. C.
   Witkamp, Renger F.
TI Effects of Nutrients on Platelet Function: A Modifiable Link between
   Metabolic Syndrome and Neurodegeneration?
SO BIOMOLECULES
LA English
DT Review
DE platelets; metabolic syndrome; neurodegeneration; nutrients
ID LOW-DENSITY LIPOPROTEINS; MILD COGNITIVE IMPAIRMENT;
   CEREBRAL-BLOOD-FLOW; OXIDATIVE STRESS; ARACHIDONIC-ACID; IN-VITRO;
   ENDOTHELIAL DYSFUNCTION; ORAL SUPPLEMENTATION; PHOSPHOLIPASE A(2);
   DISTRIBUTION WIDTH
AB Metabolic syndrome increases the risk of vascular dementia and other neurodegenerative disorders. Recent studies underline that platelets play an important role in linking peripheral with central metabolic and inflammatory mechanisms. In this narrative review, we address the activation of platelets in metabolic syndrome, their effects on neuronal processes and the role of the mediators (e.g., serotonin, platelet-derived growth factor). Emerging evidence shows that nutritional compounds and their metabolites modulate these interactions-specifically, long chain fatty acids, endocannabinoids and phenolic compounds. We reviewed the role of activated platelets in neurovascular processes and nutritional compounds in platelet activation.</p>
C1 [Arnoldussen, Ilse A. C.; Witkamp, Renger F.] Wageningen Univ & Res, Human Nutr & Hlth, Dept Agrotechnol & Food Sci, NL-6708 WE Wageningen, Netherlands.
   [Arnoldussen, Ilse A. C.] Radboud Univ Nijmegen Med Ctr, Dept Med Imaging, Anat, Donders Inst Brain Cognit & Behav, NL-6525 EZ Nijmegen, Netherlands.
C3 Wageningen University & Research; Radboud University Nijmegen
RP Arnoldussen, IAC (corresponding author), Wageningen Univ & Res, Human Nutr & Hlth, Dept Agrotechnol & Food Sci, NL-6708 WE Wageningen, Netherlands.; Arnoldussen, IAC (corresponding author), Radboud Univ Nijmegen Med Ctr, Dept Med Imaging, Anat, Donders Inst Brain Cognit & Behav, NL-6525 EZ Nijmegen, Netherlands.
EM Ilse.Arnoldussen@radboudumc.nl; Renger.Witkamp@wur.nl
RI Witkamp, Renger/I-7622-2012; Arnoldussen, Ilse/H-4421-2015
OI Arnoldussen, Ilse/0000-0002-7395-5284; Witkamp,
   Renger/0000-0002-7935-8261
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NR 161
TC 6
Z9 8
U1 0
U2 9
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2218-273X
J9 BIOMOLECULES
JI Biomolecules
PD OCT
PY 2021
VL 11
IS 10
AR 1455
DI 10.3390/biom11101455
PG 18
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA WO2MF
UT WOS:000712293100001
PM 34680088
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Zhao, JY
   Duan, LY
   Li, JR
   Yao, CS
   Wang, GQ
   Mi, J
   Yu, YJ
   Ding, L
   Zhao, YY
   Yan, GC
   Li, J
   Zhao, ZX
   Wang, XG
   Li, M
AF Zhao, Jinyue
   Duan, Liyun
   Li, Jiarui
   Yao, Chensi
   Wang, Guoqiang
   Mi, Jia
   Yu, Yongjiang
   Ding, Lu
   Zhao, Yunyun
   Yan, Guanchi
   Li, Jing
   Zhao, Zhixuan
   Wang, Xiuge
   Li, Min
TI New insights into the interplay between autophagy, gut microbiota and
   insulin resistance in metabolic syndrome
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Article
DE Autophagy; Intestinal homeostasis; Gut microbiota; Metabolic Syndrome;
   Insulin resistance; Chronic inflammation
ID ENDOPLASMIC-RETICULUM STRESS; INDUCIBLE FACTOR 2-ALPHA; CHAIN
   FATTY-ACIDS; OXIDATIVE STRESS; ER STRESS; INTESTINAL MICROBIOTA;
   MEDIATED AUTOPHAGY; SERUM METABOLOME; AMINO-ACIDS; BILE-ACIDS
AB Metabolic syndrome (MetS) is a widespread and multifactorial disorder, and the study of its pathogenesis and treatment remains challenging. Autophagy, an intracellular degradation system that maintains cellular renewal and homeostasis, is essential for maintaining antimicrobial defense, preserving epithelial barrier integrity, promoting mucosal immune response, maintaining intestinal homeostasis, and regulating gut microbiota and microbial metabolites. Dysfunctional autophagy is implicated in the pathological mechanisms of MetS, involving insulin resistance (IR), chronic inflammation, oxidative stress, and endoplasmic reticulum (ER) stress, with IR being a predominant feature. The study of autophagy represents a valuable field of research with significant clinical implications for identifying autophagy-related signals, pathways, mechanisms, and treatment options for MetS. Given the multifactorial etiology and various potential risk factors, it is imperative to explore the interplay between autophagy and gut microbiota in MetS more thoroughly. This will facilitate the elucidation of new mechanisms underlying the crosstalk among autophagy, gut microbiota, and MetS, thereby providing new insights into the diagnosis and treatment of MetS.
C1 [Zhao, Jinyue; Li, Jiarui; Ding, Lu; Yan, Guanchi; Li, Jing; Zhao, Zhixuan] Changchun Univ Chinese Med, Coll Tradit Chinese Med, Changchun 130021, Peoples R China.
   [Duan, Liyun] Shandong Univ Tradit Chinese Med, Clin Med Coll 1, Jinan 250355, Peoples R China.
   [Duan, Liyun] Shandong Univ Tradit Chinese Med, Affiliated Hosp, Jinan 250014, Peoples R China.
   [Yao, Chensi; Li, Min] China Acad Chinese Med Sci, Guanganmen Hosp, Mol Biol Lab, Beijing 100053, Peoples R China.
   [Wang, Guoqiang; Mi, Jia; Yu, Yongjiang; Zhao, Yunyun; Wang, Xiuge] Changchun Univ Chinese Med, Affiliated Hosp, Changchun 130021, Peoples R China.
C3 Changchun University of Chinese Medicine; Shandong University of
   Traditional Chinese Medicine; Shandong University of Traditional Chinese
   Medicine; China Academy of Chinese Medical Sciences; Guang'anmen
   Hospital, CACMS; Changchun University of Chinese Medicine
RP Li, M (corresponding author), China Acad Chinese Med Sci, Guanganmen Hosp, Mol Biol Lab, Beijing 100053, Peoples R China.; Wang, XG (corresponding author), Changchun Univ Chinese Med, Affiliated Hosp, Changchun 130021, Peoples R China.
EM xiuge_w@163.com; limin-72114@163.com
RI 李, 佳睿/JDW-5769-2023
FU Scientific and technological innovation project of China Academy of the
   Chinese Medical Sciences [CI2021A01606]; Clinical Research Center
   Construction Project of Guang'anmen Hospital, CACMS [2022 LYJSZX04]
FX This work was supported by the Scientific and technological innovation
   project of China Academy of the Chinese Medical Sciences (CI2021A01606)
   , and the Clinical Research Center Construction Project of Guang'anmen
   Hospital, CACMS (Grant No. 2022 LYJSZX04) . The funders had no role in
   the study design, data collection, data analysis, interpretation, or
   writing of the report.
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NR 183
TC 8
Z9 8
U1 12
U2 20
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD JUL
PY 2024
VL 176
AR 116807
DI 10.1016/j.biopha.2024.116807
EA MAY 2024
PG 11
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA UD9G9
UT WOS:001246236000001
PM 38795644
OA gold
DA 2025-06-11
ER

PT J
AU Kuo, LE
   Kitlinska, JB
   Tilan, JU
   Li, LJ
   Baker, SB
   Johnson, MD
   Lee, EW
   Burnett, MS
   Fricke, ST
   Kvetnansky, R
   Herzog, H
   Zukowska, Z
AF Kuo, Lydia E.
   Kitlinska, Joanna B.
   Tilan, Jason U.
   Li, Lijun
   Baker, Stephen B.
   Johnson, Michael D.
   Lee, Edward W.
   Burnett, Mary Susan
   Fricke, Stanley T.
   Kvetnansky, Richard
   Herzog, Herbert
   Zukowska, Zofia
TI Neuropeptide Y acts directly in the periphery on fat tissue and mediates
   stress-induced obesity and metabolic syndrome
SO NATURE MEDICINE
LA English
DT Article
ID WHITE ADIPOSE-TISSUE; RAT CAROTID-ARTERY; SYMPATHETIC ACTIVATION;
   ISCHEMIC ANGIOGENESIS; GENE-EXPRESSION; OB/OB MICE; NPY; RESPONSES;
   EXERCISE; DIET
AB The relationship between stress and obesity remains elusive. In response to stress, some people lose weight, whereas others gain. Here we report that stress exaggerates diet-induced obesity through a peripheral mechanism in the abdominal white adipose tissue that is mediated by neuropeptide Y (NPY). Stressors such as exposure to cold or aggression lead to the release of NPY from sympathetic nerves, which in turn upregulates NPY and its Y2 receptors (NPY2R) in a glucocorticoid-dependent manner in the abdominal fat. This positive feedback response by NPY leads to the growth of abdominal fat. Release of NPY and activation of NPY2R stimulates fat angiogenesis, macrophage infiltration, and the proliferation and differentiation of new adipocytes, resulting in abdominal obesity and a metabolic syndrome-like condition. NPY, like stress, stimulates mouse and human fat growth, whereas pharmacological inhibition or fat-targeted knockdown of NPY2R is anti-angiogenic and anti-adipogenic, while reducing abdominal obesity and metabolic abnormalities. Thus, manipulations of NPY2R activity within fat tissue offer new ways to remodel fat and treat obesity and metabolic syndrome.
C1 Georgetown Univ, Med Ctr, Dept Physiol & Biophys, Washington, DC 20057 USA.
   Georgetown Univ, Med Ctr, Dept Plast Surg, Washington, DC 20007 USA.
   Georgetown Univ, Med Ctr, Dept Oncol, Washington, DC 20007 USA.
   MedStar Res Inst, Cardiovasc Res Inst, Washington, DC 20010 USA.
   Georgetown Univ, Med Ctr, Dept Neurosci, Washington, DC 20007 USA.
   Slovak Acad Sci, Inst Expt Endocrinol, Bratislava 83306, Slovakia.
   Gaven Inst Med Res, Sydney, NSW 2010, Australia.
C3 Georgetown University; Georgetown University; Georgetown University;
   Georgetown University; Slovak Academy of Sciences; Institute of
   Experimental Endocrinology, SAS
RP Zukowska, Z (corresponding author), Georgetown Univ, Med Ctr, Dept Physiol & Biophys, 3900 Reservoir Rd NW,BSB 234, Washington, DC 20057 USA.
EM zzukow01@georgetown.edu
RI Herzog, Herbert/B-8294-2008; Tilan, Justin/AAJ-7253-2021
OI Lee, Edward/0000-0003-0418-1454; Tilan, Jason/0000-0002-0454-5409;
   Herzog, Herbert/0000-0002-1713-1029
FU NHLBI NIH HHS [HL055310, HL067357] Funding Source: Medline; NIDCR NIH
   HHS [DE016050] Funding Source: Medline
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NR 49
TC 496
Z9 584
U1 3
U2 43
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 1078-8956
EI 1546-170X
J9 NAT MED
JI Nat. Med.
PD JUL
PY 2007
VL 13
IS 7
BP 803
EP 811
DI 10.1038/nm1611
PG 9
WC Biochemistry & Molecular Biology; Cell Biology; Medicine, Research &
   Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology; Research & Experimental
   Medicine
GA 188EU
UT WOS:000247902800026
PM 17603492
DA 2025-06-11
ER

PT J
AU McDaid, TM
   Smyth, S
AF McDaid, T. M.
   Smyth, S.
TI Metabolic abnormalities among people diagnosed with schizophrenia: a
   literature review and implications for mental health nurses
SO JOURNAL OF PSYCHIATRIC AND MENTAL HEALTH NURSING
LA English
DT Article
DE diabetes; dyslipidaemia; education; obesity; metabolic syndrome;
   schizophrenia
ID ATYPICAL ANTIPSYCHOTICS; CARDIOVASCULAR RISK; OBESITY; PREVALENCE;
   TRIAL; INTERVENTION; DYSLIPIDEMIA; GUIDELINES; MORTALITY; SMOKING
AB Accessible summary Metabolic abnormalities such as diabetes, obesity and dyslipidaemia are found in much higher rates in people with a diagnosis of schizophrenia when compared with the general population. This review discusses the most prevalent metabolic abnormalities associated with schizophrenia, their frequency and implications for mental health nurses (MHN). This review illuminates the need for MHN to acquire added awareness, knowledge and practical strategies in managing people at high risk of developing metabolic abnormalities associated with MetS. By doing this, it contributes to the literature by highlighting practical strategies for MHN in assessment and ongoing monitoring of metabolic abnormalities in clinical practice. This review highlights the need for MHN to be vigilant in monitoring a person's physical state on commencement and throughout treatment with antipsychotics. There is a need for an early detection monitoring system for people who are potentially at risk of developing metabolic abnormalities.
   AbstractThe literature review aimed to investigate metabolic abnormalities associated with metabolic syndrome (MetS) in people diagnosed with schizophrenia; they are almost twice as likely to have metabolic risk factors and die approximately 20 years younger than the general population. MetS has become an issue of growing concern in mental health nursing. A comprehensive literature review was conducted utilizing various databases to address the reviews aim. Databases such as CINAHL Plus with full text (via EBSCO), MEDLINE(R) (OVID), PsycINFO and the COCHRANE library were accessed. The main metabolic abnormalities that emerged were: diabetes, obesity and dyslipidaemia. Antipsychotic medication also plays a vital role in a person's susceptibility to the development of MetS. It is critical that MHN has access to training and education in managing people at high risk of developing metabolic abnormalities associated with MetS. This review contributes to the literature by highlighting practical strategies for MHN in assessment and ongoing monitoring of metabolic abnormalities in clinical practice.
C1 [McDaid, T. M.] Hlth Serv Execut, Acute Mental Hlth Unit, Mayo, Ireland.
   [Smyth, S.] Natl Univ Ireland, Sch Nursing & Midwifery, Galway, Ireland.
C3 Ollscoil na Gaillimhe-University of Galway
RP McDaid, TM (corresponding author), Hlth Serv Execut, Acute Mental Hlth Unit, Mayo, Ireland.
EM tm.mcdaid@gmail.com
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NR 47
TC 24
Z9 27
U1 0
U2 15
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1351-0126
EI 1365-2850
J9 J PSYCHIATR MENT HLT
JI J. Psychiatr. Ment. Health Nurs.
PD APR
PY 2015
VL 22
IS 3
BP 157
EP 170
DI 10.1111/jpm.12185
PG 14
WC Nursing; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Psychiatry
GA CE2UW
UT WOS:000351676200002
PM 25524393
DA 2025-06-11
ER

PT J
AU Pershadsingh, HA
AF Pershadsingh, Harrihar A.
TI α-Lipoic acid:: physiologic mechanisms and indications for the treatment
   of metabolic syndrome
SO EXPERT OPINION ON INVESTIGATIONAL DRUGS
LA English
DT Review
DE alpha-lipoic acid; AMP kinase; antioxidant; dyslipidemia; hypertension;
   insulin resistance; lipotoxicity; metabolic syndrome; obesity; oxidative
   stress; peroxisome proliferator-activated receptors; PPAR-gamma; Type 2
   diabetes; weight loss
ID ACTIVATED PROTEIN-KINASE; PREVENTS LIPOTOXIC CARDIOMYOPATHY;
   NONALCOHOLIC FATTY LIVER; OXIDATIVE STRESS; SKELETAL-MUSCLE; INSULIN
   SENSITIVITY; OBESE RATS; TRANSCRIPTION FACTORS; INDUCED HYPERTENSION;
   GLUCOSE-METABOLISM
AB In animal experiments, the potent antioxidant and free radical scavenger alpha-lipoic acid has been shown to cause weight loss, ameliorate insulin resistance and atherogenic dyslipidemia, as well as to lower blood pressure, all of these being components of the metabolic syndrome. Recent investigations on its mechanisms of action indicate that alpha-lipoic acid can affect central and peripheral modulation of 5'-AMP-activated protein kinase, activate PPAR-alpha and PPAR-gamma, modulate PPAR-regulated genes and upregulate the expression of PPAR-gamma mRNA and protein in cardiac tissue and aorta smooth muscle. To a large extent, these findings can explain the observed beneficial metabolic effects of alpha-lipoic acid, supporting its potential application as a therapeutic agent for the treatment of the metabolic syndrome.
C1 Bethesda Pharmaceut Inc, Bakersfield, CA 93311 USA.
RP Pershadsingh, HA (corresponding author), Bethesda Pharmaceut Inc, 404 Windsor Pk Dr, Bakersfield, CA 93311 USA.
EM hpershad@UCI.edu
FU NIAMS NIH HHS [2R42AR44767-02A2] Funding Source: Medline
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NR 105
TC 32
Z9 39
U1 0
U2 7
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1354-3784
EI 1744-7658
J9 EXPERT OPIN INV DRUG
JI Expert Opin. Investig. Drugs
PD MAR
PY 2007
VL 16
IS 3
BP 291
EP 302
DI 10.1517/13543784.16.3.291
PG 12
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 142ML
UT WOS:000244653900004
PM 17302524
DA 2025-06-11
ER

PT J
AU Clemmer, JS
   Xiang, LS
   Lu, SL
   Mittwede, PN
   Hester, RL
AF Clemmer, John S.
   Xiang, Lusha
   Lu, Silu
   Mittwede, Peter N.
   Hester, Robert L.
TI Hyperglycemia-Mediated Oxidative Stress Increases Pulmonary Vascular
   Permeability
SO MICROCIRCULATION
LA English
DT Article
DE hyperglycemia; lung permeability; metabolic syndrome
ID PROTEIN-KINASE-C; NADPH OXIDASE ACTIVATION; ZUCKER OBESE RATS;
   ENDOTHELIAL DYSFUNCTION; POSTCHALLENGE HYPERGLYCEMIA; INDUCED
   VASODILATION; INSULIN-RESISTANCE; NAD(P)H OXIDASE; COMPLEX-I; METFORMIN
AB ObjectiveHyperglycemia in diabetes mellitus is associated with endothelial dysfunction as evidenced by increased oxidative stress and vascular permeability. Whether impaired glucose control in metabolic syndrome impacts pulmonary vascular permeability is unknown. We hypothesized that in metabolic syndrome, hyperglycemia increases lung vascular permeability through superoxide.
   MethodsLung capillary Kf and vascular superoxide were measured in the isolated lungs of LZ and OZ rats. OZ were subjected to 4weeks of metformin treatment (300mg/kg/day orally) to improve insulin sensitivity. In a separate experiment, lung vascular permeability and vascular superoxide were measured in LZ exposed to acute hyperglycemia (30mM).
   ResultsAs compared to LZ, OZ had impaired glucose and insulin tolerance and elevated vascular superoxide which was associated with an elevated lung Kf. Chronic metformin treatment in OZ improved glucose control and insulin sensitivity which was associated with decreased vascular oxidative stress and lung Kf. Acute hyperglycemia in isolated lungs from LZ increased lung Kf, which was blocked with the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase inhibitor, apocynin (3mM). Apocynin also decreased baseline Kf in OZ.
   ConclusionsThese data suggest that hyperglycemia in metabolic syndrome exacerbates lung vascular permeability through increases in vascular superoxide, possibly through NADPH oxidase.
C1 [Clemmer, John S.; Xiang, Lusha; Lu, Silu; Mittwede, Peter N.; Hester, Robert L.] Univ Mississippi, Med Ctr, Dept Physiol & Biophys, 2500 North State St, Jackson, MS 39216 USA.
C3 University of Mississippi; University of Mississippi Medical Center
RP Hester, RL (corresponding author), Univ Mississippi, Med Ctr, Dept Physiol & Biophys, 2500 North State St, Jackson, MS 39216 USA.
EM rhester@umc.edu
RI Hester, Robert/HNS-3185-2023; Xiang, Lusha/JXY-0496-2024; Mittwede,
   Peter/U-1419-2019; Lu, Silu/P-7249-2014
OI Hester, Robert/0000-0003-0227-557X; Clemmer, John/0000-0003-2250-2960
FU American Heart Association [AHA-14PRE20380069, AHA-12SDG12050525,
   AHA-12POST12060126]; National Institutes of Health [NIH-P20GM104357,
   HL-51971, HL-89581, T32 HL-105324]; American Heart Association (AHA)
   [14PRE20380069, 12SDG12050525, 12POST12060126] Funding Source: American
   Heart Association (AHA)
FX We thank Haiyan Zhang for performing the hormonal analysis. We also
   thank our funding sources. This work was supported by the American Heart
   Association (AHA-14PRE20380069, AHA-12SDG12050525, AHA-12POST12060126)
   and the National Institutes of Health (NIH-P20GM104357, HL-51971,
   HL-89581, T32 HL-105324.)
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NR 57
TC 21
Z9 22
U1 0
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1073-9688
EI 1549-8719
J9 MICROCIRCULATION
JI Microcirculation
PD APR
PY 2016
VL 23
IS 3
BP 221
EP 229
DI 10.1111/micc.12267
PG 9
WC Hematology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Hematology; Cardiovascular System & Cardiology
GA DI6NY
UT WOS:000373617500005
PM 26749564
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Boudreau, DM
   Malone, DC
   Raebel, MA
   Fishman, PA
   Nichols, GA
   Feldstein, AC
   Boscoe, AN
   Ben-Joseph, RH
   Magid, DJ
   Okamoto, LJ
AF Boudreau, D. M.
   Malone, D. C.
   Raebel, M. A.
   Fishman, P. A.
   Nichols, G. A.
   Feldstein, A. C.
   Boscoe, A. N.
   Ben-Joseph, R. H.
   Magid, D. J.
   Okamoto, L. J.
TI Health Care Utilization and Costs by Metabolic Syndrome Risk Factors
SO METABOLIC SYNDROME AND RELATED DISORDERS
LA English
DT Article
ID INTERNATIONAL-DIABETES-FEDERATION; CARDIOVASCULAR-DISEASE; ABDOMINAL
   FAT; ALL-CAUSE; MORTALITY; ADULTS; PREVALENCE; OVERWEIGHT; DEPRESSION;
   MELLITUS
AB Background: This study compared prevalent health utilization and costs for persons with and without metabolic syndrome and investigated the independent associations of the various factors that make up metabolic syndrome.
   Methods: Subjects were enrollees of three health plans who had all clinical measurements ( blood pressure, fasting plasma glucose, body mass index, triglycerides, and high-density lipoprotein cholesterol) necessary to determine metabolic syndrome risk factors over the 2-year study period (n = 170,648). We used clinical values, International Classification of Diseases, Ninth Revision (ICD-9) diagnoses, and medication dispensings to identify risk factors. We report unadjusted mean annual utilization and modeled mean annual costs adjusting for age, sex, and co-morbidity.
   Results: Subjects with metabolic syndrome ( n = 98,091) had higher utilization and costs compared to subjects with no metabolic syndrome ( n = 72,557) overall, and when stratified by diabetes ( P < 0.001). Average annual total costs between subjects with metabolic syndrome versus no metabolic syndrome differed by a magnitude of 1.6 overall ($5,732 vs. $3,581), and a magnitude of 1.3 when stratified by diabetes (diabetes, $7,896 vs. $6,038; no diabetes, $4,476 vs. $3,422). Overall, total costs increased by an average of 24% per additional risk factor ( P < 0.001). Costs and utilization differed by risk factor clusters, but the more prevalent clusters were not necessarily the most costly. Costs for subjects with diabetes plus weight risk, dyslipidemia, and hypertension were almost double the costs for subjects with prediabetes plus similar risk factors ($8,067 vs. $4,638).
   Conclusions: Metabolic syndrome, number of risk factors, and specific combinations of risk factors are markers for high utilization and costs among patients receiving medical care. Diabetes and certain risk clusters are major drivers of utilization and costs.
C1 [Boudreau, D. M.] United BioSource Corp, Ctr Hlth Studies, Grp Hlth, Seattle, WA 98101 USA.
   [Boudreau, D. M.; Okamoto, L. J.] United BioSource Corp, Bethesda, MD USA.
   [Malone, D. C.; Magid, D. J.] Univ Arizona, Tucson, AZ USA.
   [Raebel, M. A.] Kaiser Permanente, Colorado Clin Res Unit, Denver, CO USA.
   [Nichols, G. A.; Feldstein, A. C.] Kaiser Permanente, NW Ctr Hlth Res, Portland, OR USA.
   [Boscoe, A. N.] Genzyme, Cambridge, MA USA.
   [Ben-Joseph, R. H.] Sanofi Aventis, Bridgewater, NJ USA.
C3 United Biosource Corporation; United Biosource Corporation; University
   of Arizona; Kaiser Permanente; Kaiser Permanente; Sanofi-Aventis; Sanofi
   USA; Genzyme Corporation; Sanofi-Aventis; Sanofi USA
RP Boudreau, DM (corresponding author), United BioSource Corp, Ctr Hlth Studies, Grp Hlth, 1417 4th Ave,Ste 510, Seattle, WA 98101 USA.
EM denise.boudreau@unitedbiosource.com
RI , David/X-5730-2019
OI Boscoe, Audra/0000-0001-8342-173X
FU United BioSource Corporation through their contract with Sanofi-Aventis
FX This study was funded by United BioSource Corporation through their
   contract with Sanofi-Aventis.
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NR 42
TC 161
Z9 188
U1 1
U2 21
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-4196
EI 1557-8518
J9 METAB SYNDR RELAT D
JI Metab. Syndr. Relat. Disord.
PD AUG
PY 2009
VL 7
IS 4
BP 305
EP 313
DI 10.1089/met.2008.0070
PG 9
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Research & Experimental Medicine
GA 477UE
UT WOS:000268543600005
PM 19558267
DA 2025-06-11
ER

PT J
AU de Oliveira, C
   Scarabelot, VL
   de Souza, A
   de Oliveira, CM
   Medeiros, LF
   de Macedo, IC
   Marques, PR
   Cioato, SG
   Caumo, W
   Torres, ILS
AF de Oliveira, Carla
   Scarabelot, Vanessa Leal
   de Souza, Andressa
   de Oliveira, Cleverson Moraes
   Medeiros, Liciane Fernandes
   de Macedo, Isabel Cristina
   Marques Filho, Paulo Ricardo
   Cioato, Stefania Giotti
   Caumo, Wolnei
   Torres, Iraci L. S.
TI Obesity and chronic stress are able to desynchronize the temporal
   pattern of serum levels of leptin and triglycerides
SO PEPTIDES
LA English
DT Article
DE Temporal pattern; Obesity; Metabolic syndrome; Hypercaloric diet;
   Chronic stress
ID DIET-INDUCED OBESITY; CENTRAL-NERVOUS-SYSTEM; METABOLIC SYNDROME;
   CIRCADIAN-RHYTHMS; ADIPOSE-TISSUE; CARDIOVASCULAR-DISEASE;
   DIURNAL-VARIATION; RESTRAINT STRESS; NEUROPEPTIDE-Y; SHIFT WORK
AB Disruption of the circadian system can lead to metabolic dysfunction as a response to environmental alterations. This study assessed the effects of the association between obesity and chronic stress on the temporal pattern of serum levels of adipogenic markers and corticosterone in rats. We evaluated weekly weight, delta weight, Lee index, and weight fractions of adipose tissue (mesenteric, MAT; subcutaneous, SAT; and pericardial, PAT) to control for hypercaloric diet-induced obesity model efficacy. Wistar rats were divided into four groups: standard chow (C), hypercaloric diet (HD), stress plus standard chow (S), and stress plus hypercaloric diet (SHD), and analyzed at three time points: ZTO, ZT12, and ZT18. Stressed animals were subjected to chronic stress for 1 h per day, 5 days per week, during 80 days. The chronic exposure to a hypercaloric diet was an effective model for the induction of obesity and metabolic syndrome, increasing delta weight, Lee index, weight fractions of adipose tissue, and triglycerides and leptin levels. We confirmed the presence of a temporal pattern in the release of triglycerides, corticosterone, leptin, and adiponectin in naive animals. Chronic stress reduced delta weight, MAT weight, and levels of triglycerides, total cholesterol, and leptin. There were interactions between chronic stress and obesity and serum total cholesterol levels, between time points and obesity and adiponectin and corticosterone levels, and between time points and chronic stress and serum leptin levels. In conclusion, both parameters were able to desynchronize the temporal pattern of leptin and triglyceride release, which could contribute to the development of metabolic diseases such as obesity and metabolic syndrome. (C) 2013 Elsevier Inc. All rights reserved.
C1 [de Oliveira, Carla; Scarabelot, Vanessa Leal; de Souza, Andressa; de Oliveira, Cleverson Moraes; Medeiros, Liciane Fernandes; de Macedo, Isabel Cristina; Marques Filho, Paulo Ricardo; Cioato, Stefania Giotti; Caumo, Wolnei; Torres, Iraci L. S.] Univ Fed Rio Grande do Sul, Inst Basic Hlth Sci, Dept Pharmacol, Anim Models Lab, BR-90050170 Porto Alegre, RS, Brazil.
   [de Oliveira, Carla; de Souza, Andressa; de Oliveira, Cleverson Moraes; Marques Filho, Paulo Ricardo; Cioato, Stefania Giotti; Caumo, Wolnei; Torres, Iraci L. S.] Univ Fed Rio Grande do Sul, Post Grad Program Med Med Sci, BR-90035003 Porto Alegre, RS, Brazil.
   [de Oliveira, Carla; Scarabelot, Vanessa Leal; de Souza, Andressa; de Oliveira, Cleverson Moraes; Medeiros, Liciane Fernandes; de Macedo, Isabel Cristina; Marques Filho, Paulo Ricardo; Cioato, Stefania Giotti; Torres, Iraci L. S.] Hosp Clin Porto Alegre, Anim Experimentat Unit, BR-90035003 Porto Alegre, RS, Brazil.
   [de Oliveira, Carla; Scarabelot, Vanessa Leal; de Souza, Andressa; de Oliveira, Cleverson Moraes; Medeiros, Liciane Fernandes; de Macedo, Isabel Cristina; Marques Filho, Paulo Ricardo; Cioato, Stefania Giotti; Torres, Iraci L. S.] Hosp Clin Porto Alegre, Grad Res Grp, BR-90035003 Porto Alegre, RS, Brazil.
   [Scarabelot, Vanessa Leal; Medeiros, Liciane Fernandes; de Macedo, Isabel Cristina; Torres, Iraci L. S.] Univ Fed Rio Grande do Sul, Inst Basic Hlth Sci, Post Grad Program Biol Sci Physiol, BR-90050170 Porto Alegre, RS, Brazil.
   [de Souza, Andressa] Ctr Univ Univates, Ctr Ciencias Basicas Saude, Lab Bioquim, BR-95900000 Lajeado, RS, Brazil.
C3 Universidade Federal do Rio Grande do Sul; Universidade Federal do Rio
   Grande do Sul; Hospital de Clinicas de Porto Alegre; Hospital de
   Clinicas de Porto Alegre; Universidade Federal do Rio Grande do Sul;
   Universidade do Vale do Taquari
RP Torres, ILS (corresponding author), Univ Fed Rio Grande do Sul, Dept Farmacol ICBS, Rua Sarmento Leite,500 Sala 202, BR-90050170 Porto Alegre, RS, Brazil.
EM iracitorres@gmail.com
RI caumo, wolnei/Q-8728-2016; Oliveira, Carla/F-6351-2015; Torres, Iraci
   LS/G-6693-2012; Souza, Andressa/Q-2446-2016; Fernandes Medeiros,
   Liciane/A-3626-2014; Oliveira, Cleverson/HPE-1938-2023
OI Caumo, Wolnei/0000-0002-5083-4658; Torres, Iraci LS/0000-0002-3081-115X;
   Souza, Andressa/0000-0002-6608-4695; Fernandes Medeiros,
   Liciane/0000-0002-6842-7241; Giotti Cioato,
   Stefania/0000-0002-1854-0713; Oliveira, Cleverson/0000-0003-0861-6136;
   Macedo, Isabel Cristina/0000-0001-6215-1371
FU National Council for Scientific and Technological Development, CNPq;
   Committee for the Improvement of Higher Education Personnel, CAPES;
   Graduate Research Group of Hospital de Clinicas de Porto Alegre, GPPG
   [100383]
FX This study was supported by the following Brazilian funding agencies:
   the National Council for Scientific and Technological Development, CNPq
   (Dr. I.L.S. Torres, Dr. W. Caumo, V.L. Scarabelot; and S.G. Cioato); the
   Committee for the Improvement of Higher Education Personnel, CAPES (C.
   de Oliveira; A. de Souza; C.M. de Oliveira, I.C. de Macedo; and L.F.
   Medeiros); and the Graduate Research Group of Hospital de Clinicas de
   Porto Alegre, GPPG (I.L.S. Torres, Grant 100383).
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NR 77
TC 26
Z9 27
U1 0
U2 14
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0196-9781
EI 1873-5169
J9 PEPTIDES
JI Peptides
PD JAN
PY 2014
VL 51
BP 46
EP 53
DI 10.1016/j.peptides.2013.10.024
PG 8
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism;
   Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism;
   Pharmacology & Pharmacy
GA 282XO
UT WOS:000329208100008
PM 24184591
DA 2025-06-11
ER

PT J
AU Reed, R
   Potter, B
   Smith, E
   Jadhav, R
   Villalta, P
   Jo, H
   Rocic, P
AF Reed, Ryan
   Potter, Barry
   Smith, Erika
   Jadhav, Rashmi
   Villalta, Patricia
   Jo, Hanjoong
   Rocic, Petra
TI Redox-sensitive Akt and Src regulate coronary collateral growth in
   metabolic syndrome
SO AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
LA English
DT Article
DE signal transduction; oxidative stress; coronary artery disease; syndrome
   X
ID INTERMITTENT MYOCARDIAL-ISCHEMIA; VASCULAR SMOOTH-MUSCLE; OXIDATIVE
   STRESS; NADPH OXIDASE; HINDLIMB ISCHEMIA; CARDIAC MYOCYTES; NAD(P)H
   OXIDASE; GENE-EXPRESSION; ARTERY GROWTH; CANINE MODEL
AB Reed R, Potter B, Smith E, Jadhav R, Villalta P, Jo H, Rocic P. Redox-sensitive Akt and Src regulate coronary collateral growth in metabolic syndrome. Am J Physiol Heart Circ Physiol 296: H1811-H1821, 2009. First Published April 17, 2009; doi:10.1152/ajpheart.00920.2008.-We have recently shown that the inability of repetitive ischemia (RI) to activate p38 MAPK (p38) and Akt in metabolic syndrome [JCR:LA-cp (JCR)] rats was associated with impaired coronary collateral growth (CCG). Furthermore, Akt and p38 activation correlated with optimal O-2(-)center dot levels and were altered in JCR rats, and redox-sensitive p38 activation was required for CCG. Here, we determined whether the activation of Src, a possible upstream regulator, was altered in JCR rats and whether redox-dependent Src and Akt activation were required for CCG. CCG was assessed by myocardial blood flow (microspheres) and kinase activation was assessed by Western blot analysis in the normal zone and collateral-dependent zone (CZ). RI induced Src activation (similar to 3-fold) in healthy [Wistar-Kyoto (WKY)] animals but not in JCR animals. Akt inhibition decreased (similar to 50%), and Src inhibition blocked RI-induced CCG in WKY rats. Src inhibition decreased p38 and Akt activation. Myocardial oxidative stress (O-2(-)center dot and oxidized/reduced thiols) was measured quantitatively (X-band electron paramagnetic resonance). An antioxidant, apocynin, reduced RI- induced oxidative stress in JCR rats to levels induced by RI in WKY rats versus the reduction in WKY rats to very low levels. This resulted in a significant restoration of p38 (similar to 80%), Akt (similar to 65%), and Src (similar to 90%) activation in JCR rats but decreased the activation in WKY rats (p38: similar to 45%, Akt: similar to 65%, and Src: similar to 100%), correlating with reduced CZ flow in WKY rats (similar to 70%), but significantly restored CZ flow in JCR rats (similar to 75%). We conclude that 1) Akt and Src are required for CCG, 2) Src is a redox-sensitive upstream regulator of RI- induced p38 and Akt activation, and 3) optimal oxidative stress levels are required for RI- induced p38, Akt, and Src activation and CCG.
C1 [Smith, Erika; Jadhav, Rashmi; Villalta, Patricia; Rocic, Petra] Univ S Alabama, Coll Med, Dept Biochem & Mol Biol, Mobile, AL 36688 USA.
   [Reed, Ryan] Louisiana State Univ, Hlth Sci Ctr, Dept Biochem, New Orleans, LA USA.
   [Potter, Barry] Louisiana State Univ, Hlth Sci Ctr, Dept Physiol, New Orleans, LA USA.
   [Jo, Hanjoong] Georgia Inst Technol, Coulter Dept Biomed Engn, Atlanta, GA 30332 USA.
   [Jo, Hanjoong] Emory Univ, Dept Med, Div Cardiol, Atlanta, GA 30322 USA.
C3 University of South Alabama; Louisiana State University System;
   Louisiana State University Health Sciences Center New Orleans; Louisiana
   State University System; Louisiana State University Health Sciences
   Center New Orleans; University System of Georgia; Georgia Institute of
   Technology; Emory University
RP Rocic, P (corresponding author), Univ S Alabama, Coll Med, Dept Biochem & Mol Biol, 307 N Univ Blvd, Mobile, AL 36688 USA.
EM procic@usouthal.edu
RI JADHAV, RASHMI/GQI-2890-2022; Jo, Hanjoong/L-6216-2019
OI Rocic, Petra/0000-0002-5781-3075; Jo, Hanjoong/0000-0003-1833-372X
FU American Heart Association [SDG0630285N]; National Institutes of Health
   [RR-018766, R01-HL-093052]
FX This work was supported by American Heart Association Grant SDG0630285N
   and by National Institutes of Health Center of Biomedical Research
   Excellence Grants RR-018766 and R01-HL-093052.
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NR 46
TC 21
Z9 23
U1 0
U2 2
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0363-6135
EI 1522-1539
J9 AM J PHYSIOL-HEART C
JI Am. J. Physiol.-Heart Circul. Physiol.
PD JUN
PY 2009
VL 296
IS 6
BP H1811
EP H1821
DI 10.1152/ajpheart.00920.2008
PG 11
WC Cardiac & Cardiovascular Systems; Physiology; Peripheral Vascular
   Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Physiology
GA 450JT
UT WOS:000266397500014
PM 19376806
OA Green Published
DA 2025-06-11
ER

PT J
AU Krug, AW
   Ehrhart-Bornstein, M
AF Krug, A. W.
   Ehrhart-Bornstein, M.
TI Adrenocortical dysfunction in obesity and the metabolic syndrome
SO HORMONE AND METABOLIC RESEARCH
LA English
DT Review
DE adrenal glands; aldosterone; metabolic syndrome; obesity; arterial
   hypertension
ID MYOCARDIAL-INFARCTION; ADRENAL RESPONSE; ANGIOTENSIN-II; ADIPOSE-TISSUE;
   HEART-FAILURE; STRESS SYSTEM; ALDOSTERONE; HYPERTENSION; CORTISOL;
   MORTALITY
AB Recently, it has become evident that the adrenals play a key role in obesity as well as in the metabolic syndrome and their complications. On the one hand, adrenal steroids are involved in physiological regulation of adipose tissue and energy homeostasis and in the pathogenesis of cardiometabolic complications. On the other hand, fat cell-derived factors, adipocytokines, and lipids released from adipose tissue are involved in the modulation of adrenal steroidogenesis. Aldosterone plasma levels are elevated in obesity and in patients with the metabolic syndrome. Recent research has provided evidence that adipocytes secrete factors that stimulate adrenal mineralocorticoid release and sensitize the adrenal cortex to angiotensin II.
C1 [Krug, A. W.; Ehrhart-Bornstein, M.] Carl Gustav Carus Univ Hosp, Dept Internal Med 3, Dresden, Germany.
C3 Technische Universitat Dresden; Carl Gustav Carus University Hospital
RP Krug, AW (corresponding author), Tech Univ Dresden, Dept Endocrinol Diabetol & Metab, Med Clin 3, Fetscherstr 74, D-01307 Dresden, Germany.
EM Alexander.Krug@uniklinikum-dresden.de
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NR 36
TC 24
Z9 27
U1 0
U2 6
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0018-5043
J9 HORM METAB RES
JI Horm. Metab. Res.
PD AUG
PY 2008
VL 40
IS 8
BP 515
EP 517
DI 10.1055/s-2008-1073154
PG 3
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 336KE
UT WOS:000258361900002
PM 18446685
DA 2025-06-11
ER

PT J
AU Esposito, V
   Manente, L
   Viglietti, R
   Parrella, G
   Parrella, R
   Gargiulo, M
   Sangiovanni, V
   Perna, A
   Baldi, A
   De Luca, A
   Chirianni, A
AF Esposito, Vincenzo
   Manente, Lucrezia
   Viglietti, Rosaria
   Parrella, Giovanni
   Parrella, Roberto
   Gargiulo, Miriam
   Sangiovanni, Vincenzo
   Perna, Angelica
   Baldi, Alfonso
   De Luca, Antonio
   Chirianni, Antonio
TI Comparative Transcriptional Profiling in HIV-Infected Patients Using
   Human Stress Arrays: Clues to Metabolic Syndrome
SO IN VIVO
LA English
DT Article
DE HAART; HIV infection; lipodystrophy; oxidative stress; metabolic
   syndrome; antiretroviral therapies
ID ADIPOCYTE DIFFERENTIATION; SUPEROXIDE-DISMUTASE; V(D)J RECOMBINATION;
   ANTIRETROVIRAL TREATMENT; GENE-EXPRESSION; RAG PROTEINS; CANCER;
   IMMUNOPHILINS; LIPODYSTROPHY; ACTIVATION
AB Highly active antiretroviral therapy (HAART therapy) for HIV-1 infection has significantly increased the survival and quality of life of patients with this disease. However, in several epidemiological studies the onset of metabolic syndrome is a phenomenon reported to be extremely frequent. In the present study, genes involved in the molecular cascade responsible for the alteration of fat tissue and of lipid and glucose metabolism in patients with HIV-1 infection treated with antiretroviral therapy were identified. Towards this goal, hybridization using Atlas cDNA Expression Arrays allowed simultaneous monitoring of the expression levels of approximately 250 genes and identification of a panel of changes in relation to different therapeutic groups and in the presence of metabolic syndrome, with some genes being up-regulated, while others are down-regulated in the different subgroups of patients. The results of this analysis have shown a panel of transcriptional changes associated with oxidative stress mechanisms that provide a basis for further studies on understanding of mechanisms that, in vivo, are the foundation the metabolic disorders in patients with HIV infection.
C1 [Esposito, Vincenzo; Viglietti, Rosaria; Parrella, Giovanni; Parrella, Roberto; Gargiulo, Miriam; Sangiovanni, Vincenzo; Chirianni, Antonio] Third Div Cotugno Hosp, Naples, Italy.
   [Manente, Lucrezia; Perna, Angelica; De Luca, Antonio] Univ Naples 2, Dept Med & Publ Hlth, Sect Human Anat, Naples, Italy.
   [Baldi, Alfonso] Univ Naples 2, Dept Biochem, Sect Pathol, Naples, Italy.
C3 Universita della Campania Vanvitelli; Universita della Campania
   Vanvitelli
RP Esposito, V (corresponding author), Terza Div Malattie Infett AO Cotugno, Via G Quagliariello 54, I-80131 Naples, Italy.
EM esposvin@libero.it
RI Perna, Angelica/S-8292-2019; Baldi, Alfonso/ABG-2397-2021; De Luca,
   Antonio/AAD-9562-2020
OI Baldi, Alfonso/0000-0002-8693-3842; perna, angelica/0000-0002-7853-9159
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NR 45
TC 8
Z9 8
U1 0
U2 0
PU INT INST ANTICANCER RESEARCH
PI ATHENS
PA EDITORIAL OFFICE 1ST KM KAPANDRITIOU-KALAMOU RD KAPANDRITI, PO BOX 22,
   ATHENS 19014, GREECE
SN 0258-851X
EI 1791-7549
J9 IN VIVO
JI In Vivo
PD MAR-APR
PY 2012
VL 26
IS 2
BP 237
EP 242
PG 6
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 899ET
UT WOS:000300798800010
PM 22351664
DA 2025-06-11
ER

PT J
AU Tootsi, K
   Märtson, A
   Kals, J
   Paapstel, K
   Zilmer, M
AF Tootsi, Kaspar
   Martson, Aare
   Kals, Jaak
   Paapstel, Kaido
   Zilmer, Mihkel
TI Metabolic factors and oxidative stress in osteoarthritis: a case-control
   study
SO SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION
LA English
DT Article
DE Osteoarthritis; dyslipidemia; obesity; oxidative stress; metabolic
   syndrome X
ID KNEE OSTEOARTHRITIS; NATIONAL-HEALTH; RISK-FACTORS; PATHOGENESIS;
   INFLAMMATION; CLASSIFICATION; ASSOCIATION; HOMEOSTASIS; PROGRESSION;
   STIFFNESS
AB Previous studies suggest that metabolic disturbances might be involved in the development of osteoarthritis (OA). Associations have been found between the individual components of metabolic syndrome (MetS) and OA. MetS has been associated with increased oxidative stress (OxS). The study aimed to clarify the role of MetS components in OA and to evaluate the levels of OxS in OA patients and in age-matched controls. Fifty-five patients with end-stage OA (age 63 +/- 7 years) prior to hip or knee joint replacement surgery and 55 age-, gender- and body mass index matched controls (61 +/- 8 years) were enrolled in the study. Serum levels of glucose, insulin, c-peptide, cholesterols and OxS markers were recorded. Homeostasis model assessment for insulin resistance was used as the proxy measure of insulin resistance. Radiographic severity was assessed using the Kellgren-Lawrence score. The OA patients had higher total peroxide concentration and oxidative stress index [488 (250-612)mol/L vs. 326 (168-442)mol/L, p=.011 and 34 (17-51) vs. 20 (11-28), p=.002, respectively] and decreased total antioxidant capacity (1.49 +/- 0.27 vs. 1.66 +/- 0.27mmol trolox equivalent/L, p=.008) compared with the controls. In addition, OA group had significantly higher level of C-peptide compared with the controls [1.8 (0.94-2.47) vs. 1.3 (0.46-1.42)ng/mL, p<.001, respectively]. Furthermore, OA radiographic severity was independently associated with LDL-cholesterol (p=.007) and oxidized LDL (p=.022). This study demonstrates that end-stage OA patients have increased levels of OxS and decreased antioxidant capacity. OA is associated with impaired lipid metabolism and dysglycemia. Our results underline the importance OxS and metabolic disturbances in the pathogenesis of OA.
C1 [Tootsi, Kaspar; Martson, Aare] Univ Tartu, Dept Traumatol & Orthopaed, Puusepa 8, Tartu, Estonia.
   [Tootsi, Kaspar; Kals, Jaak; Paapstel, Kaido] Univ Tartu, Endothelial Ctr, Tartu, Estonia.
   [Tootsi, Kaspar; Martson, Aare; Kals, Jaak; Paapstel, Kaido; Zilmer, Mihkel] Univ Tartu, Inst Biomed & Translat Med, Dept Biochem, Ctr Excellence Genom & Translat Med, Tartu, Estonia.
   [Martson, Aare] Tartu Univ Hosp, Clin Traumatol & Orthopaed, Tartu, Estonia.
   [Kals, Jaak] Univ Tartu, Dept Surg, Tartu, Estonia.
C3 University of Tartu; University of Tartu; University of Tartu;
   University of Tartu
RP Tootsi, K (corresponding author), Univ Tartu, Dept Traumatol & Orthopaed, Puusepa 8, Tartu, Estonia.
EM kaspar.tootsi@kliinikum.ee
RI Paapstel, Kaido/D-3191-2017; Kals, Jaak/AAI-2689-2020; Tootsi,
   Kaspar/O-1355-2019; Martson, Aare/AAQ-8714-2020; Tootsi,
   Kaspar/D-5186-2017
OI Martson, Aare/0000-0003-4857-484X; Tootsi, Kaspar/0000-0003-2151-9031;
   Kals, Jaak/0000-0002-8745-718X
FU Personal Institutional Research Funding [GMVBS19]; Institutional
   Research Funding from the Estonian Research Council [IUT20-42]; European
   Union [2014-2020.4.01.15-0012]; U Seventh Framework Programme [602398]
FX We gratefully acknowledge assistance from the staff of the Department of
   Traumatology and Orthopaedics of the University of Tartu, in sample
   collection and radiographic evaluation. We also thank Ester Jaigma for
   linguistic revision of the text of the manuscript. This study was
   supported by Personal Institutional Research Funding (GMVBS19) and by
   Institutional Research Funding (No. IUT20-42) from the Estonian Research
   Council and by the European Union through the European Regional
   Development Fund (Project No. 2014-2020.4.01.15-0012) and the EU Seventh
   Framework Programme (No. 602398, HypOrth).
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NR 41
TC 35
Z9 37
U1 0
U2 14
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0036-5513
EI 1502-7686
J9 SCAND J CLIN LAB INV
JI Scand. J. Clin. Lab. Invest.
PY 2017
VL 77
IS 7
BP 520
EP 526
DI 10.1080/00365513.2017.1354255
PG 7
WC Medical Laboratory Technology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology; Research & Experimental Medicine
GA FF8OG
UT WOS:000409277100007
PM 28737953
DA 2025-06-11
ER

PT J
AU Yardim-Akaydin, S
   Caliskan-Can, E
   Gökalp, F
   Firat, H
   Ardic, S
   Simsek, B
AF Yardim-Akaydin, Sevgi
   Caliskan-Can, Emel
   Gokalp, Firat
   Firat, Hikmet
   Ardic, Sadik
   Simsek, Bolkan
TI Lipid peroxidation and DNA damage in apnea patients with or without
   metabolic syndrome
SO SLEEP AND BIOLOGICAL RHYTHMS
LA English
DT Article
DE 8-hydroxydeoxyguanosine; apnea; malondialdehyde; metabolic syndrome
ID OBSTRUCTIVE SLEEP-APNEA; POSITIVE AIRWAY PRESSURE; OXIDATIVE STRESS;
   HYPOXIA; PLASMA; BLOOD; CHROMATOGRAPHY; INFLAMMATION; DYSFUNCTION;
   PATHWAYS
AB Oxidative stress is one of the pathophysiological pathways suggested for the development of cardiovascular diseases in obstructive sleep apnea. The recurrent nocturnal episodes of hypoxia/reoxygenation observed in patients with obstructive sleep apnea (OSA) appear to be partly responsible for the increased oxidative stress. We investigated the relationship between lipid peroxidation and DNA damage in OSA patients with or without metabolic syndrome (MetS). 117 patients that had recently diagnosed OSA with or without MetS, and 25 control subjects were studied. Plasma malondialdehyde (MDA) levels in fasting blood samples were measured by a high-performance liquid chromatography method and urine 8-hydroxydeoxyguanosine (8-OHdG) was accessed by a competitive ELISA kit method. The levels of MDA and 8-OHdG were significantly higher in total apnea patients than in the controls (P < 0.0001 and P < 0.005, respectively). Apnea patients with metabolic syndrome had slightly higher MDA and lower 8-OHdG levels than those in the patients without metabolic syndrome. The values of 8-OHdG was correlated with T%SaO2 < 90, T%SaO2 < %85, mean SaO2 (%), and the lowest SaO2 (%) (R = 0.511, P = 0.000, R = 0.420, P = 0.001, R = -0.448, P = 0.000, and R = -0.437, P = 0.001, respectively) in the severe apnea patients. Significant increases in the levels of MDA and 8-OHdG support the studies suggesting possible involvement of oxidative stress in OSA. According to the state of the MetS, there is no significant difference in the levels of oxidative stress markers in OSA patients with or without MetS. High correlations between 8-OHdG and oxygen saturation levels in severe apnea group indicate the role of hypoxia/reoxygenation in DNA damage.
C1 [Yardim-Akaydin, Sevgi; Caliskan-Can, Emel; Gokalp, Firat; Simsek, Bolkan] Gazi Univ, Fac Pharm, Dept Biochem, TR-06330 Etiler Ankara, Turkey.
   [Firat, Hikmet; Ardic, Sadik] Diskapi Yildirim Beyazit & Training & Res Hosp, Minist Hlth, Sleep Disorders Diag & Treatment Ctr, Dept Chest Dis, Ankara, Turkey.
C3 Gazi University; Diskapi Yildirim Beyazit Training & Research Hospital;
   Ministry of Health - Turkey
RP Yardim-Akaydin, S (corresponding author), Gazi Univ, Fac Pharm, Dept Biochem, TR-06330 Etiler Ankara, Turkey.
EM sevgiy@gazi.edu.tr
RI AKAYDIN, Sevgi/AHB-3268-2022; FIRAT, Hikmet/E-3047-2017
OI FIRAT, Hikmet/0000-0003-2594-4887; AKAYDIN, Sevgi/0000-0002-0927-5188
FU Gazi University Research Fund [02/2006-26]
FX A part of this study was supported by Gazi University Research Fund
   (Project No: 02/2006-26). The study protocol was approved by the local
   Ethics Committee.
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NR 38
TC 6
Z9 7
U1 0
U2 6
PU SPRINGER JAPAN KK
PI TOKYO
PA SHIROYAMA TRUST TOWER 5F, 4-3-1 TORANOMON, MINATO-KU, TOKYO, 105-6005,
   JAPAN
SN 1446-9235
EI 1479-8425
J9 SLEEP BIOL RHYTHMS
JI Sleep Biol. Rhythms
PD APR
PY 2013
VL 11
IS 2
BP 116
EP 124
DI 10.1111/sbr.12012
PG 9
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 126BX
UT WOS:000317587400007
DA 2025-06-11
ER

PT J
AU Vlassara, H
   Cai, WJ
   Tripp, E
   Pyzik, R
   Yee, K
   Goldberg, L
   Tansman, L
   Chen, X
   Mani, V
   Fayad, ZA
   Nadkarni, GN
   Striker, GE
   He, JC
   Uribarri, J
AF Vlassara, Helen
   Cai, Weijing
   Tripp, Elizabeth
   Pyzik, Renata
   Yee, Kalle
   Goldberg, Laurie
   Tansman, Laurie
   Chen, Xue
   Mani, Venkatesh
   Fayad, Zahi A.
   Nadkarni, Girish N.
   Striker, Gary E.
   He, John C.
   Uribarri, Jaime
TI Oral AGE restriction ameliorates insulin resistance in obese individuals
   with the metabolic syndrome: a randomised controlled trial
SO DIABETOLOGIA
LA English
DT Article
DE AGER1; Cardiovascular disease; Diabetes; Glycotoxins; Inflammation;
   Innate defence; RAGE; SIRT1
ID ADVANCED GLYCATION ENDPRODUCTS; END-PRODUCTS; DIABETES-MELLITUS;
   OXIDATIVE STRESS; RISK; DIETARY; HEALTHY; DISEASE; SIRT1; FOODS
AB Aims/hypothesis We previously reported that obese individuals with the metabolic syndrome (at risk), compared with obese individuals without the metabolic syndrome (healthy obese), have elevated serum AGEs that strongly correlate with insulin resistance, oxidative stress and inflammation. We hypothesised that a diet low in AGEs (L-AGE) would improve components of the metabolic syndrome in obese individuals, confirming high AGEs as a new risk factor for the metabolic syndrome.
   Methods A randomised 1 year trial was conducted in obese individuals with the metabolic syndrome in two parallel groups: L-AGE diet vs a regular diet, habitually high in AGEs (Reg-AGE). Participants were allocated to each group by randomisation using random permuted blocks. At baseline and at the end of the trial, we obtained anthropometric variables, blood and urine samples, and performed OGTTs and MRI measurements of visceral and subcutaneous abdominal tissue and carotid artery. Only investigators involved in laboratory determinations were blinded to dietary assignment. Effects on insulin resistance (HOMA-IR) were the primary outcome.
   Results Sixty-one individuals were randomised to a Reg-AGE diet and 77 to an L-AGE diet; the data of 49 and 51, respectively, were analysed at the study end in 2014. The L-AGE diet markedly improved insulin resistance; modestly decreased body weight; lowered AGEs, oxidative stress and inflammation; and enhanced the protective factors sirtuin 1, AGE receptor 1 and glyoxalase I. The Reg-AGE diet raised AGEs and markers of insulin resistance, oxidative stress and inflammation. There were no effects on MRI-assessed measurements. No side effects from the intervention were identified. HOMA-IR came down from 3.1 +/- 1.8 to 1.9 +/- 1.3 (p < 0.001) in the L-AGE group, while it increased from 2.9 +/- 1.2 to 3.6 +/- 1.7 (p < 0.002) in the Reg-AGE group.
   Conclusions/interpretation L-AGE ameliorates insulin resistance in obese people with the metabolic syndrome, and may reduce the risk of type 2 diabetes, without necessitating a major reduction in adiposity. Elevated serum AGEs may be used to diagnose and treat 'at-risk' obesity.
C1 [Vlassara, Helen; Cai, Weijing; Tripp, Elizabeth; Pyzik, Renata; Yee, Kalle; Goldberg, Laurie; Tansman, Laurie; Chen, Xue; Striker, Gary E.] Icahn Sch Med Mt Sinai, Dept Geriatr, Div Expt Diabet & Aging, One Gustave L Levy Pl, New York, NY 10029 USA.
   [Vlassara, Helen] Icahn Sch Med Mt Sinai, Dept Med, New York, NY 10029 USA.
   [Mani, Venkatesh; Fayad, Zahi A.] Icahn Sch Med Mt Sinai, Translat & Mol Imaging Inst, New York, NY 10029 USA.
   [Nadkarni, Girish N.; Striker, Gary E.; He, John C.; Uribarri, Jaime] Icahn Sch Med Mt Sinai, Dept Med, Div Nephrol, New York, NY 10029 USA.
C3 Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at
   Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of
   Medicine at Mount Sinai
RP Uribarri, J (corresponding author), Icahn Sch Med Mt Sinai, Dept Med, Div Nephrol, New York, NY 10029 USA.
EM Jaime.uribarri@mssm.edu
RI Fayad, Zahi/Z-3272-2019; Uribarri, Jaime/ADX-7655-2022; mirzaei,
   hamed/X-2374-2018; Mani, Venkatesh/B-8939-2011
OI He, John/0000-0002-1502-2849; Mani, Venkatesh/0000-0002-0432-2918;
   uribarri, jaime/0000-0001-9826-1134
FU National Institutes of Health [DK091231]; National Institute of Research
   Resources [MO1-RR-00071]
FX This work was supported by the National Institutes of Health (grant
   DK091231 to HV) and by the National Institute of Research Resources
   (grant MO1-RR-00071 to the General Clinical Research Center at Mount
   Sinai School of Medicine) for clinical and statistical support.
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NR 39
TC 106
Z9 110
U1 0
U2 21
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0012-186X
EI 1432-0428
J9 DIABETOLOGIA
JI Diabetologia
PD OCT
PY 2016
VL 59
IS 10
BP 2181
EP 2192
DI 10.1007/s00125-016-4053-x
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA DV7NI
UT WOS:000383122800017
PM 27468708
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Dimitrijevic-Sreckovic, V
   Colak, E
   Djordjevic, P
   Gostiljac, D
   Sreckovic, B
   Popovic, S
   Canovic, F
   Ilic, M
   Obrenovic, R
   Vukcevic, V
   Nikolic, D
   Nisic, T
   Milic, G
   Pejcic, G
AF Dimitrijevic-Sreckovic, Vesna
   Colak, Emina
   Djordjevic, Predrag
   Gostiljac, Drasko
   Sreckovic, Branko
   Popovic, Srdjan
   Canovic, Fadil
   Ilic, Miroijub
   Obrenovic, Radmila
   Vukcevic, Vladan
   Nikolic, Dragan
   Nisic, Tanja
   Milic, Gordana
   Pejcic, Gordana
TI Prothrombogenic factors and reduced antioxidative defense in children
   and adolescents with pre-metabolic and metabolic syndrome
SO CLINICAL CHEMISTRY AND LABORATORY MEDICINE
LA English
DT Article; Proceedings Paper
CT 3rd Santorini Biologie Prospective Conference
CY SEP 29-OCT 02, 2006
CL Santorini, GREECE
DE antioxidative defense; children/adolescents; metabolic syndrome;
   plasminogen activator inhibitor-1; pre-metabolic syndrome
ID CARDIOVASCULAR RISK; WAIST CIRCUMFERENCE; OXIDATIVE STRESS; OBESITY;
   INSULIN; PREVALENCE
AB Background: The aim of this study was to examine prothrombogenic factors and antioxidative defense in obese children and adolescents with pre-metabolic and metabolic syndrome, and to analyze insulin secretion and resistance, early glycoregulation disorders and lipid status.
   Methods: Insulin sensitivity was determined using the homeostasis model assessment for insulin resistance (HOMA-IR), while insulin secretion was determined using the homeostasis model assessment beta (HOMA-beta). Prothrombogenic factors analyzed were plasma plasminogen activator inhibitor-1 (PAI-1) and fibrinogen. Superoxide dismutase and glutathione peroxdase were measured as markers of antioxidative defense.
   Results: Patients with metabolic syndrome were characterized with increased body mass index (BMI), waist circumference, and HOMA-IR and HOMA-beta levels, and all had increased blood pressure and triglyceride levels, low high-density lipoprotein cholesterol levels, increased PAI-1 levels and reduced antioxidative defense levels. Patients with pre-metabolic syndrome had higher levels of basal and mean insulinemia during an oral glucose tolerance test, higher levels of HOMA-beta and lower levels of antioxidative defense compared to patients with metabolic syndrome.
   Conclusions: Negative correlations between antioxidative defense parameters and BMI, abdominal obesity, insulin secretion, systolic blood pressure and atherogenic lipid factors, as well as correlations between PAI-1 and insulin resistance and basal glycemia in the metabolic syndrome group contribute to accelerated atherosclerosis. Positive correlations between PAI-1 and waist circumference and BMI, and negative correlations between BMI and antioxidative defense in the pre-metabolic syndrome patients show that this early stage preceding the metabolic syndrome is also characterized by atherosclerotic complication risks and evident hyperinsulinism and insulin resistance.
C1 Clin Ctr Serbia, Inst Endocrinol Diab & Metab Dis, Belgrade, Serbia.
   Clin Ctr Serbia, Inst Med Biochem, Belgrade, Serbia.
   Clin Ctr Serbia, Inst Cardiovasc Dis, Belgrade, Serbia.
C3 Clinical Centre of Serbia; Clinical Centre of Serbia; Clinical Centre of
   Serbia
RP Dimitrijevic-Sreckovic, V (corresponding author), Krupanjska 24, Belgrade 11000, Serbia.
EM vesnadsendo@ptt.yu
RI Čolak, Emina/AAQ-1969-2021
OI Nikolic, Dragan/0000-0001-5919-1575
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NR 23
TC 24
Z9 27
U1 0
U2 1
PU WALTER DE GRUYTER GMBH
PI BERLIN
PA GENTHINER STRASSE 13, D-10785 BERLIN, GERMANY
SN 1434-6621
EI 1437-4331
J9 CLIN CHEM LAB MED
JI Clin. Chem. Lab. Med.
PY 2007
VL 45
IS 9
BP 1140
EP 1144
DI 10.1515/CCLM.2007.259
PG 5
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Medical Laboratory Technology
GA 217KY
UT WOS:000249948000006
PM 17848118
DA 2025-06-11
ER

PT J
AU Uguz, AC
   Demirci, K
   Espino, J
AF Uguz, Abdulhadi Cihangir
   Demirci, Kadir
   Espino, Javier
TI The Importance of Melatonin and Mitochondria Interaction in Mood
   Disorders and Schizophrenia: A Current Assessment
SO CURRENT MEDICINAL CHEMISTRY
LA English
DT Review
DE Bipolar disorder; Calcium signaling; Depression; Mitochondria; Mood
   disorder; Oxidative stress; Schizophrenia
ID ELECTRON-MICROSCOPY; METABOLIC SYNDROME; LITHIUM TREATMENT; BIPOLAR
   DISORDER; DOUBLE-BLIND; COMPLEX-I; CALCIUM; DEPRESSION; CELLS; PATHWAYS
AB Mitochondria play a critical role in regulating cellular functions, such as redox signaling, calcium homeostasis, and apoptosis. Also, mitochondria are crucial for neurogenesis and neuronal functions. Melatonin is an indole analog hormone, which is generally produced by the pineal gland. It plays a vital role in circadian rhythm and act as a powerful antioxidant by scavenging free radicals, immunomodulators, and anticancer agents. Schizophrenia and mood disorders are the two major psychiatric disorders. Disturbances of sleep and circadian rhythms are well-known symptoms of schizophrenia and mood disorders (bipolar disorder, major depression). Since melatonin has a regulator effect on circadian rhythm and sleep quality, it has a close interaction with schizophrenia and mood disorders. Herein, we aimed to summarize the effects of melatonin on mitochondrial activity in schizophrenia and mood disorders.
C1 [Uguz, Abdulhadi Cihangir] Suleyman Demirel Univ, Sch Med, Dept Biophys, Isparta, Turkey.
   [Demirci, Kadir] Suleyman Demirel Univ, Sch Med, Dept Psychiat, Isparta, Turkey.
   [Espino, Javier] Univ Extremadura, Fac Sci, Neuroimmunophysiol & Chrononutr Res Grp, Dept Physiol, Badajoz 06006, Spain.
C3 Suleyman Demirel University; Suleyman Demirel University; Universidad de
   Extremadura
RP Uguz, AC (corresponding author), Suleyman Demirel Univ, Sch Med, Dept Biophys, Isparta, Turkey.
EM cihangiruguz@sdu.edu.tr
RI Uğuz, A. Cihangir/J-8531-2012; Espino, Javier/B-6002-2017
OI Espino, Javier/0000-0002-8549-9343
FU Gobierno de Extremadura (European Regional Development Fund (ERDF))
   [PO14011]
FX J. Espino holds a research post-doctoral fellowship from Gobierno de
   Extremadura (jointly financed by the European Regional Development Fund
   (ERDF); ref. PO14011).
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NR 105
TC 11
Z9 11
U1 0
U2 16
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 0929-8673
EI 1875-533X
J9 CURR MED CHEM
JI Curr. Med. Chem.
PY 2016
VL 23
IS 20
BP 2146
EP 2158
DI 10.2174/0929867323666160428105849
PG 13
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Pharmacology &
   Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
GA DS4YL
UT WOS:000380787500006
PM 27121187
DA 2025-06-11
ER

PT J
AU Maloney, EM
   Boneva, RS
   Lin, JMS
   Reeves, WC
AF Maloney, Elizabeth M.
   Boneva, Roumiana S.
   Lin, Jin-Mann S.
   Reeves, William C.
TI Chronic fatigue syndrome is associated with metabolic syndrome: results
   from a case-control study in Georgia
SO METABOLISM-CLINICAL AND EXPERIMENTAL
LA English
DT Article
ID ALLOSTATIC LOAD; HEALTH; DISEASE; STRESS; INFLAMMATION; DEFINITION;
   PREVALENCE; MACARTHUR; MORTALITY; DIAGNOSIS
AB We hypothesized that persons with chronic fatigue syndrome (CFS) would have a higher prevalence of metabolic syndrome compared with well controls, and that unwell persons with insufficient symptoms or fatigue for CFS (termed ISF) would have a prevalence of metabolic syndrome intermediate between those with CFS and the controls We also sought to examine the relationship between metabolic syndrome and measures of functional impairment, fatigue, and other symptoms Our analysis was based on a population-based case-control study conducted in metropolitan, urban, and rural areas of Georgia, United States, between September 2004 and July 2005 There were 111 persons with CFS, 259 with ISF, and 123 controls. Metabolic syndrome was determined based on having at least 3 of 5 standard risk components (abdominal obesity, high triglycerides, high blood pressure, elevated fasting glucose, and decreased high-density lipids) according to the National Cholesterol Education Program Adult Treatment Panel III definition Persons with CFS were 2-fold as likely to have metabolic syndrome (odds ratio = 2 12, confidence interval = 1 06, 4 23) compared with the controls. There was a significant graded relationship between the number of metabolic syndrome factors and CFS, each additional factor was associated with a 37% increase in likelihood of having CFS The association of ISF. with metabolic syndrome was weaker (odds ratio = 1 72, confidence interval = 0 94-3.16) Among persons with CFS, the number of metabolic syndrome factors was significantly correlated with worse fatigue on a standardized summary measure of fatigue (r = 0 20, P = 04) In conclusion, CFS was associated with metabolic syndrome, which further exacerbated fatigue Published by Elsevier Inc
C1 [Maloney, Elizabeth M.; Boneva, Roumiana S.; Lin, Jin-Mann S.; Reeves, William C.] Ctr Dis Control & Prevent, Chron Viral Dis Branch, Natl Ctr Zoonot Vector Borne & Enter Dis, Atlanta, GA 30333 USA.
C3 Centers for Disease Control & Prevention - USA
RP Maloney, EM (corresponding author), Ctr Dis Control & Prevent, Chron Viral Dis Branch, Natl Ctr Zoonot Vector Borne & Enter Dis, MS-A15,1600 Clifton Rd, Atlanta, GA 30333 USA.
FU US government
FX This research was supported in its entirety by the US government. The
   findings and conclusions in this report are those of the authors and do
   not necessarily represent the views of the funding agency.
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NR 39
TC 51
Z9 57
U1 0
U2 9
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0026-0495
EI 1532-8600
J9 METABOLISM
JI Metab.-Clin. Exp.
PD SEP
PY 2010
VL 59
IS 9
BP 1351
EP 1357
DI 10.1016/j.metabol.2009.12.019
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 645SY
UT WOS:000281487700016
PM 20102774
DA 2025-06-11
ER

PT J
AU Hayden, MR
   Tyagi, SC
AF Hayden, Melvin R.
   Tyagi, Suresh C.
TI Intimal redox stress: Accelerated atherosclerosis in metabolic syndrome
   and type 2 diabetes mellitus. Atheroscleropathy
SO CARDIOVASCULAR DIABETOLOGY
LA English
DT Review
DE Atherosclerosis; Atheroscleropathy; Oxidative stress; ROS (reactive
   oxygen species); RNS (reactive nitrogen species); Reductive stress
ID NITRIC-OXIDE SYNTHASE; C-REACTIVE PROTEIN; CORONARY-HEART-DISEASE;
   TO-RETENTION HYPOTHESIS; COENZYME-A REDUCTASE; INSULIN-RESISTANCE;
   OXIDATIVE STRESS; CARDIOVASCULAR-DISEASE; NAD(P)H OXIDASE; CROSS-LINKING
AB Metabolic syndrome, insulin resistance, prediabetes, and overt type 2 diabetes mellitus are associated with an accelerated atherosclerosis (atheroscleropathy). This quartet is also associated with multiple metabolic toxicities resulting in the production of reactive oxygen species. The redox stress associated with these reactive oxygen species contribute to the development, progression, and the final fate of the arterial vessel wall in prediabetic and diabetic atheroscleropathy. The prevention of morbidity and mortality of these intersecting metabolic diseases can be approached through comprehensive global risk reduction.
C1 [Hayden, Melvin R.] Univ Missouri Columbia, Dept Family & Community Med, Columbia, MO USA.
   [Tyagi, Suresh C.] Univ Mississippi Med Ctr Jackson, Dept Physiol & Biophys, Jackson, MS 39216 USA.
C3 University of Missouri System; University of Missouri Columbia;
   University of Mississippi Medical Center
RP Hayden, MR (corresponding author), Univ Missouri Columbia, Dept Family & Community Med, Columbia, MO USA.
EM mrh29@usmo.com; styagi@physiology.umsmed.edu
FU National Institutes of Health [HL-71010]
FX A part of this study was supported by National Institutes of Health
   grant HL-71010. The authors are aware that this review is lengthy but
   remains incomplete as each section discussed is worthy of at least a
   chapter. We have attempted to share the complex interaction of the
   multiple toxicities and redox stress to provide a database of
   information and references for those who wish to continue their studies
   in this exciting, exponentially growing field of study. We wish to thank
   our many friends and colleagues who have helped us grow in this field of
   study. To our heroic professors, who instilled in us the quest for
   knowledge and the lack of fear, to ask, "why" and "why not".
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NR 140
TC 80
Z9 86
U1 0
U2 5
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1475-2840
J9 CARDIOVASC DIABETOL
JI Cardiovasc. Diabetol.
PY 2002
VL 1
AR 3
DI 10.1186/1475-2840-1-3
PG 27
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism
GA V23DA
UT WOS:000208322300003
PM 12392600
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Almeida, OP
   Calver, J
   Jamrozik, K
   Hankey, GJ
   Flicker, L
AF Almeida, Osvaldo P.
   Calver, Janine
   Jamrozik, Konrad
   Hankey, Graeme J.
   Flicker, Leon
TI Obesity and Metabolic Syndrome Increase the Risk of Incident Depression
   in Older Men: The Health in Men Study
SO AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
LA English
DT Article
DE Obesity; metabolic syndrome; depression; depressive disorder; affective
   disorder; men; aged; elderly; epidemiology; incidence; prevention
ID BODY-MASS INDEX; WAIST-HIP RATIO; CARDIOVASCULAR-DISEASE; VASCULAR
   DEPRESSION; MOOD DISORDERS; YOUNG-ADULTS; ASSOCIATION; SYMPTOMS; WEIGHT;
   MORTALITY
AB Background: Obesity has been associated with increased risk of prevalent depression among young and middle-aged adults, but the association between obesity (and its various measures, including the metabolic syndrome [MetS]) and incident depression has not been examined adequately in the elderly. Objectives: This study evaluated the association between various measures of obesity and incident depression over a 10-year period in a large cohort of community-based older men. Methods: The authors recruited 12,216 men aged 65-84 years living in Perth, Australia, between 1996 and 1998, and measured their height, weight, waist and hip circumference, and blood pressure. Participants also completed a questionnaire that included information about the clinical diagnosis and treatment for diabetes, hypertension, and high cholesterol or triglycerides. The authors then used the Western Australian Linked Data System to retrieve information about the following ICD-10 diagnoses between January 1, 1966, and December 31, 2006: depressive episode, recurrent depressive disorder, and dysthymia. Results: The authors excluded 150 men from these analyses because of prior history of depression or missing data. The mean age of our 12,066 participants was 72 +/- 4 years at the time of recruitment, and they were followed up for an average of 8 +/- 2 years. There were 3,623 deaths during follow-up, and 481 men received the diagnosis of depression. The incidence of depression was 5 per 1,000 person-years. Adjusted Cox proportional hazard models showed that men with body mass index (BMI) >= 30 had a 31% (95% confidence interval [CI] = 5%-64%) increase in the risk of depression compared with that of nonobese men (BMI < 30). The association between depression and waist circumference >= 102 cm and waist/hip >= 1 did not reach statistical significance. Men with MetS at the time of recruitment had a 137% (95% CI = 60%-251%) increase in the adjusted risk of incident depression. Conclusions: Our results indicate that obesity and MetS are associated with an increase in the risk of incident depression among older men. If this association is truly causal, reducing the prevalence of obesity and MetS could potentially lead to a decline in the prevalence and incidence of depression in later life. (Am J Geriatr Psychiatry 2009; 17:889-898)
C1 [Almeida, Osvaldo P.] Univ Western Australia, Sch Psychiat & Clin Neurosci, Crawley, WA 6009, Australia.
   [Almeida, Osvaldo P.] Royal Perth Hosp, Dept Psychiat, Perth, WA, Australia.
   [Jamrozik, Konrad] Univ Adelaide, Sch Populat Hlth & Clin Practice, Adelaide, SA 5005, Australia.
   [Hankey, Graeme J.; Flicker, Leon] Univ Western Australia, Sch Med & Pharmacol, Crawley, WA 6009, Australia.
   [Hankey, Graeme J.] Royal Perth Hosp, Dept Neurol, Stroke Unit, Perth, WA, Australia.
   [Flicker, Leon] Royal Perth Hosp, Dept Geriatr Med, Perth, WA, Australia.
C3 University of Western Australia; East Metropolitan Health Service; Royal
   Perth Hospital; University of Western Australia; University of Adelaide;
   University of Western Australia; East Metropolitan Health Service; Royal
   Perth Hospital; University of Western Australia; University of Western
   Australia; East Metropolitan Health Service; Royal Perth Hospital
RP Almeida, OP (corresponding author), Univ Western Australia, WA Ctr Hlth & Ageing M573, 35 Stirling Highway, Crawley, WA 6009, Australia.
EM osvaldo.almeida@uwa.edu.au
RI Alan, Janine/AAA-4037-2019; Flicker, Leon/A-9039-2008; Jamil,
   Kazi/ABX-6965-2022; Almeida, Osvaldo/A-4925-2008; Hankey,
   Graeme/H-4968-2014; Alan, Janine/A-6340-2015
OI Almeida, Osvaldo/0000-0002-8689-6199; Hankey,
   Graeme/0000-0002-6044-7328; Alan, Janine/0000-0002-1481-2881; Flicker,
   Leon/0000-0002-3650-0475
FU National Health and Medical Research Council of Australia (NHMRC)
   [279408, 379600, 403963]
FX This work was supported by National Health and Medical Research Council
   of Australia (NHMRC) project grant numbers 279408, 379600, and 403963
   (to KJ, GJH, LF, and OPA).
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NR 54
TC 71
Z9 78
U1 3
U2 20
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1064-7481
EI 1545-7214
J9 AM J GERIAT PSYCHIAT
JI Am. J. Geriatr. Psychiatr.
PD OCT
PY 2009
VL 17
IS 10
BP 889
EP 898
DI 10.1097/JGP.0b013e3181b047e3
PG 10
WC Geriatrics & Gerontology; Gerontology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Psychiatry
GA 501LG
UT WOS:000270382800009
PM 19910877
DA 2025-06-11
ER

PT J
AU Bartoli, F
   Crocamo, C
   Gennaro, GM
   Castagna, G
   Trotta, G
   Clerici, M
   Carrà, G
AF Bartoli, Francesco
   Crocamo, Cristina
   Gennaro, Giulia Maria
   Castagna, Gloria
   Trotta, Giulia
   Clerici, Massimo
   Carra, Giuseppe
TI Exploring the association between bipolar disorder and uric acid: A
   mediation analysis
SO JOURNAL OF PSYCHOSOMATIC RESEARCH
LA English
DT Article
DE Bipolar disorder; Mediation analysis; Metabolic syndrome; Purinergic
   system; Uric acid
ID SEVERE MENTAL-ILLNESS; METABOLIC SYNDROME; DIFFERENT PHASES; MOOD
   DISORDERS; HYPERURICEMIA; SCHIZOPHRENIA; METAANALYSIS; PREVALENCE;
   MANAGEMENT; OBESITY
AB Objective: Recent evidence shows that bipolar disorder might be associated with a purinergic system dysfunction. This study aimed at (i) testing the association between bipolar disorder and uric acid serum levels, and (ii) clarifying whether this relationship is mediated by metabolic syndrome and other relevant metabolic parameters.
   Methods: Patients consecutively admitted to a Mental Health Inpatient Unit, with a diagnosis of bipolar disorder or other severe mental disorders, and an appropriate healthy control sample, were included in this cross-sectional, exploratory study. We performed linear regression analyses, to explore factors associated with uric acid levels, and formal tests of mediation to assess mediating effect of candidate variables.
   Results: 176 individuals with mental disorders and 89 healthy controls met inclusion criteria. Bipolar disorder was the only diagnostic subgroup significantly associated with increased uric acid levels. Furthermore, male gender, metabolic syndrome, as well as abdominal circumference and triglycerides levels, had a significant effect on uric acid. Relevant mediation analyses showed that the estimated effect between bipolar disorder and uric acid levels was only partially mediated by metabolic abnormalities.
   Conclusion: This study suggests a direct association between bipolar disorder and uric acid levels, only partially mediated by metabolic abnormalities. It seems consistent with results of previous studies highlighting a purinergic dysfunction in bipolar disorder and the role that purinergic modulators, lowering uric acid levels, could have in clinical practice. (C) 2016 Elsevier Inc. All rights reserved.
C1 [Bartoli, Francesco; Crocamo, Cristina; Gennaro, Giulia Maria; Castagna, Gloria; Trotta, Giulia; Clerici, Massimo; Carra, Giuseppe] Univ Milano Bicocca, Dept Med & Surg, Milan, Italy.
   [Carra, Giuseppe] UCL, Div Psychiat, London, England.
C3 University of Milano-Bicocca; University of London; University College
   London
RP Bartoli, F (corresponding author), Univ Milano Bicocca, Dept Med & Surg, Milan, Italy.
EM f.bartoli@campus.unimib.it
RI Clerici, Massimo/U-3074-2019; Crocamo, Cristina/I-4355-2019; Carra,
   Giuseppe/C-6091-2012; Bartoli, Francesco/K-5755-2016; Crocamo,
   Cristina/B-5404-2014
OI Carra, Giuseppe/0000-0002-6877-6169; Bartoli,
   Francesco/0000-0003-2612-4119; Clerici, Massimo/0000-0001-8769-6474;
   Crocamo, Cristina/0000-0002-2979-2107
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NR 32
TC 37
Z9 40
U1 0
U2 22
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-3999
EI 1879-1360
J9 J PSYCHOSOM RES
JI J. Psychosomat. Res.
PD MAY
PY 2016
VL 84
BP 56
EP 59
DI 10.1016/j.jpsychores.2016.03.014
PG 4
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA DK9FU
UT WOS:000375237000009
PM 27095160
DA 2025-06-11
ER

PT J
AU Dhane, K
   Gupta, MK
   Hyam, S
   Patil, A
AF Dhane, Ketaki
   Gupta, Manish Kumar
   Hyam, Supriya
   Patil, Abhinandan
TI Preparation and in-vitro and in-vivo
   Evaluation of Ayurvedic Formulation "Amruthotharam" Formulated by
   Classical and Modern Technique
SO INDIAN JOURNAL OF PHARMACEUTICAL EDUCATION AND RESEARCH
LA English
DT Article
DE Metabolic syndrome; Amruthotharam; Immunomodulatory
ID TERMINALIA-CHEBULA FRUIT; OXIDATIVE STRESS; EXTRACT; ANTIOXIDANTS;
   SYSTEMS; CANCER; DRUGS; RAT
AB Glucose intolerance, central obesity, hypertension, and dyslipidemia are all part of the metabolic syndrome. Thus, a number of theories have been put out to explain the development of the metabolic syndrome, including an initial condition of insulin resistance that progressed to the other elements, with obesity serving as the primary initiator of the metabolic syndrome. Thus, it can be understood that metabolic syndrome is multi related and the basic cause is inflammation. Thus, while treating the metabolic syndrome the root cause needs to be targeted and for this the ayurvedic formulation is the best solution. Amruthotharam is one of such preparation which takes care of metabolic syndrome through inflammation. "Amruthotharam" is the combination is known as Kashayam was made from three main herbs whose efficacy in treating indigestion and other stomach-related issues has been demonstrated in several cases. Three parts of Tinospora cordifolia, two parts of Terminalia chebula, and one part of Zingiber officinale are combined to create the mixture. The present study is focusing on the comparisons between the Amruthotharam a kerealian Ayurvedic medicine formulated by classical and modern technique which can be evaluated analytically and pharmacologically.
C1 [Dhane, Ketaki] PSPS Indira Inst Pharm, Dept Pharmaceut Chem, Sadavali, Maharashtra, India.
   [Gupta, Manish Kumar] Vivekananda Global Univ, Fac Pharmaceut Sci & Nursing, Dept Pharm, Jaipur, Rajasthan, India.
   [Hyam, Supriya] Shree Saraswati Inst Pharm, Dept Pharmaceut Chem, Kankavali, Maharashtra, India.
   [Patil, Abhinandan] Patil Educ Soc Deemed Univ, Dept Pharmaceut, Kolhapur, Maharashtra, India.
C3 Vivekananda Global University
RP Dhane, K (corresponding author), Indira Inst Pharm, PSPS, Sadavali 415804, Maharashtra, India.
EM archupharma21@gmail.com
RI Gupta, Manish/G-7877-2016
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NR 28
TC 1
Z9 1
U1 1
U2 1
PU ASSOC PHARMACEUTICAL TEACHERS INDIA
PI BANGALORE
PA AL-AMEEN COLL PHARMACY, OPP LALBACH MAIN GATE, HOSUR MAIN RD, BANGALORE,
   560 027, INDIA
SN 0019-5464
J9 INDIAN J PHARM EDUC
JI Indian J. Pharm. Educ. Res.
PD JAN-MAR
PY 2023
VL 57
IS 1
SU S
BP S126
EP S134
DI 10.5530/ijper.57.1s.14
PG 9
WC Education, Scientific Disciplines; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Education & Educational Research; Pharmacology & Pharmacy
GA 9X2OV
UT WOS:000949613400015
OA hybrid
DA 2025-06-11
ER

PT J
AU Bali, D
   Mami-Soualem, Z
   Belyagoubi-Benhammou, N
   Benzazoua, N
   Belarbi, C
   Kachekouche, Y
   Aldahmash, W
   Rahman, MA
   Harrath, AH
AF Bali, Djihane
   Mami-Soualem, Zoubida
   Belyagoubi-Benhammou, Nabila
   Benzazoua, Nassima
   Belarbi, Chahrazed
   Kachekouche, Youssouf
   Aldahmash, Waleed
   Rahman, Md Ataur
   Harrath, Abdel Halim
TI Peach Leaf Extract (Prunus persica L.) Mitigates Metabolic
   Syndrome and Oxidative Stress in High-Fructose Diet Rats
SO PLANTS-BASEL
LA English
DT Article
DE Prunus persica L.; phenolic compounds; oxidative
   stress; metabolic syndrome; high-fructose diet
ID ANTIOXIDANT ACTIVITIES; INSULIN; LEAVES; PHENOLICS; ASSAY
AB This study aimed to evaluate the protective effects of peach leaf extract (Prunus persica L.) against metabolic syndrome and oxidative stress in Wistar rats subjected to a high-fructose diet. The Wistar rats were divided into groups and fed a high-fructose diet, with or without supplementation of peach leaf extract. The extract was characterized by its bioactive compounds, including an organic acid yield of 53.8%, total phenolic content (TPC) of 273.36 +/- 1.929 mg GAE/g DW, flavonoid content (TFC) at 149.02 +/- 57.47 mg QE/g DW, condensed tannins (TCT) at 2.34 +/- 0.171 mg CE/g DW, and flavonols at 81.67 +/- 0.497 mg DE/g DW. In vitro tests showed significant antioxidant potential, with a total antioxidant capacity (TAC) of 44.11 +/- 6.328 mg AAE/g DW, DPPH radical scavenging activity (IC50 = 4.89 mg/mL), and reducing power assay (FRAP, IC50 = 0.525 mg/mL). The results indicated that the extract significantly reduced body weight gain, plasma insulin levels (0.30 +/- 0.00 U(IU)/mL), glycemia (0.955 +/- 0.068 g/L), total cholesterol (0.555 +/- 0.177 g/L), and triglycerides (0.720 +/- 0.141 g/L). Regarding oxidative stress markers, the extract decreased levels of malondialdehyde (MDA, 4567 +/- 121 mu mol/L), hydroperoxides (1304 +/- 288 mu mol/L), and carbonylated proteins (0.029 +/- 0.020 mu mol/L), while increasing levels of vitamin C (25.84 +/- 3.00 mg AAE/L), Oxygen Radical Absorbance Capacity (ORAC, 6.043 +/- 0.345 UA), and catalase activity (0.0052 +/- 0.00008 mu L/mL). These findings suggest that P. persica L. may alleviate impairments related to metabolic syndrome by improving metabolic profiles and reducing oxidative stress in rats fed a high-fructose diet, making it a potential dietary supplement for managing metabolic syndrome.
C1 [Bali, Djihane; Mami-Soualem, Zoubida; Belyagoubi-Benhammou, Nabila; Belarbi, Chahrazed] Univ Abou Bekr Belkaid Tlemcen, Fac Nat & Life Sci Earth & Universe Sci, Dept Biol, Nat Prod Lab, Tilimsen 13000, Algeria.
   [Benzazoua, Nassima] Univ Tlemcen, Fac Med Dr Benzerdjeb Benaouda, Lab Histol Embryol, Tilimsen 13000, Algeria.
   [Kachekouche, Youssouf] Univ Hassiba Benbouali, Fac SNV, Dept Biol, Chlef 02000, Algeria.
   [Aldahmash, Waleed; Harrath, Abdel Halim] King Saud Univ, Coll Sci, Dept Zool, Riyadh 11451, Saudi Arabia.
   [Rahman, Md Ataur] Wayne State Univ, Karmanos Canc Inst, Sch Med, Dept Oncol, Detroit, MI 48201 USA.
C3 Universite Abou Bekr Belkaid; Universite Abou Bekr Belkaid; Universite
   Hassiba Ben Bouali de Chlef; King Saud University; Wayne State
   University; Barbara Ann Karmanos Cancer Institute
RP Belyagoubi-Benhammou, N (corresponding author), Univ Abou Bekr Belkaid Tlemcen, Fac Nat & Life Sci Earth & Universe Sci, Dept Biol, Nat Prod Lab, Tilimsen 13000, Algeria.; Harrath, AH (corresponding author), King Saud Univ, Coll Sci, Dept Zool, Riyadh 11451, Saudi Arabia.
EM djihane13@live.com; mamizoubida@hotmail.fr; nabila.benhammou79@yahoo.fr;
   benznew007@gmail.com; chahrazed.be_96@outlook.fr;
   youcef.kache13@gmail.com; dhmash_28@yahoo.com; rahman23@wayne.edu;
   hharrath@ksu.edu.sa
RI Rahman, Md Ataur/AAE-1071-2019; Aldahmash, Waleed/AAY-4555-2021;
   Harrath, Abdel Halim/K-2166-2014; BELYAGOUBI BENHAMMOU,
   Nabila/AGN-0393-2022
OI BELYAGOUBI BENHAMMOU, Nabila/0000-0001-5624-4627
FU King Saud University, Riyadh, Saudi Arabia;  [RSP2025R17]
FX This project was funded by Researchers Supporting Project number
   RSP2025R17, King Saud University, Riyadh, Saudi Arabia.
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NR 58
TC 0
Z9 0
U1 0
U2 0
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
SN 2223-7747
J9 PLANTS-BASEL
JI Plants-Basel
PD APR 28
PY 2025
VL 14
IS 9
AR 1332
DI 10.3390/plants14091332
PG 20
WC Plant Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences
GA 2MG6F
UT WOS:001486018400001
PM 40364361
OA gold
DA 2025-06-11
ER

PT J
AU Rosenkilde, S
   Hoffmann, SH
   Thorsted, AB
   Horsbol, TA
   Madsen, KR
   Lehn, SF
   Kofoed-Enevoldsen, A
   Iversen, PB
   Gronkjaer, MS
   Thygesen, LC
AF Rosenkilde, Siri
   Hoffmann, Sofie Have
   Thorsted, Anne Bonde
   Horsbol, Trine Allerslev
   Madsen, Katrine Rich
   Lehn, Sara Fokdal
   Kofoed-Enevoldsen, Allan
   Iversen, Peter Bindslev
   Gronkjaer, Marie Stjerne
   Thygesen, Lau Caspar
TI Loneliness and the risk of type 2 diabetes
SO BMJ OPEN DIABETES RESEARCH & CARE
LA English
DT Article
DE Diabetes Mellitus, Type 2; Epidemiology; Mental Disorders
ID SOCIAL-ISOLATION; METABOLIC SYNDROME; ASSOCIATION
AB Introduction The incidence of type 2 diabetes is increasing globally. Recent research suggests that loneliness could be a potential risk factor for the development of type 2 diabetes. We aimed to investigate the association between loneliness and type 2 diabetes and the modifying effect of mental disorders.Research design and methods We conducted a prospective study including 465 290 adults (aged >= 16 years) who participated in either the Danish Health and Morbidity Survey or the Danish National Health Survey between 2000 and 2017. Loneliness was based on self-report, while type 2 diabetes was measured using an algorithm combining several health registers including type 2 diabetes patients treated both within the hospital sector and general practice. Cox proportional hazards regressions were used to estimate hazard ratios (HRs) and 95% confidence intervals (95% CIs).Results During a mean follow-up time of 6.3 years, 13 771 individuals (3%) developed type 2 diabetes. Feeling lonely once in a while was associated with a 14% increased risk of type 2 diabetes (95% CI 1.09 to 1.20), while feeling lonely often was associated with a 24% increased risk (95% CI 1.14 to 1.34), independent of sociodemographic factors and body mass index. The association was stronger among individuals without a mental disorder (HR 1.21, 95% CI 1.10 to 1.34 among those feeling lonely often) compared with those with a mental disorder (HR 1.07, 95% CI 0.93 to 1.23).Conclusions Loneliness independently increased the risk of type 2 diabetes. The effect was more pronounced in individuals without a mental disorder, as having a mental disorder itself likely increases the risk of type 2 diabetes. These findings emphasize the importance of addressing loneliness as a modifiable risk factor in preventing type 2 diabetes.
C1 [Rosenkilde, Siri; Hoffmann, Sofie Have; Thorsted, Anne Bonde; Horsbol, Trine Allerslev; Madsen, Katrine Rich; Lehn, Sara Fokdal; Thygesen, Lau Caspar] Univ Southern Denmark, Natl Inst Publ Hlth, Copenhagen, Denmark.
   [Lehn, Sara Fokdal; Kofoed-Enevoldsen, Allan; Iversen, Peter Bindslev] Steno Diabet Ctr Sjaelland, Holbaek, Denmark.
   [Kofoed-Enevoldsen, Allan] Nykobing Falster Sygehus, Dept Endocrinol, Nykobing, Denmark.
   [Gronkjaer, Marie Stjerne] Copenhagen Univ Hosp, Ctr Clin Res & Prevent, Copenhagen, Denmark.
C3 University of Southern Denmark; University of Copenhagen; Copenhagen
   University Hospital
RP Rosenkilde, S (corresponding author), Univ Southern Denmark, Natl Inst Publ Hlth, Copenhagen, Denmark.
EM siro@sdu.dk
RI Horsbøl, Trine/JDV-5345-2023; Rosenkilde, Siri/JFK-6016-2023; Thygesen,
   Lau/W-9096-2019; Hoffmann, Sofie/JGE-4582-2023; Thygesen,
   Lau/L-3812-2016
OI Iversen, Peter Bindslev/0000-0001-7940-6430; Rosenkilde,
   Siri/0000-0003-2662-2337; Thygesen, Lau/0000-0001-8375-5211; Allerslev
   Horsbol, Trine/0000-0002-1278-9198; Madsen, Katrine
   Rich/0000-0002-6591-9849; Hoffmann, Sofie Have/0000-0001-6558-2556
FU Capital Region, Region Zealand; Region of Southern Denmark; Central
   Denmark Region; North Denmark Region; Ministry of Health; National
   Institute of Public Health, University of Southern Denmark
FX The Danish National Health Surveys were conducted and funded by the
   Capital Region, Region Zealand, the Region of Southern Denmark, the
   Central Denmark Region, the North Denmark Region, the Ministry of
   Health, and the National Institute of Public Health, University of
   Southern Denmark.
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NR 42
TC 3
Z9 3
U1 2
U2 7
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
EI 2052-4897
J9 BMJ OPEN DIAB RES CA
JI BMJ Open Diab. Res. Care
PD MAR
PY 2024
VL 12
IS 2
AR e003934
DI 10.1136/bmjdrc-2023-003934
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA TE0Q4
UT WOS:001239471900003
PM 38479777
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Strauss-Blasche, GS
   Riedmann, B
   Schobersberger, WF
   Ekmekcioglu, C
   Riedmann, G
   Waanders, R
   Fries, D
   Mittermayr, M
   Markti, WF
   Humpeler, E
AF Strauss-Blasche, GS
   Riedmann, B
   Schobersberger, WF
   Ekmekcioglu, C
   Riedmann, G
   Waanders, R
   Fries, D
   Mittermayr, M
   Markti, WF
   Humpeler, E
TI Vacation at moderate and low altitude improves perceived health in
   individuals with metabolic syndrome
SO JOURNAL OF TRAVEL MEDICINE
LA English
DT Article
ID CORONARY-HEART-DISEASE; CHRONIC PAIN; SYNDROME-X; AMAS 2000; EXERCISE;
   THERAPY; STRESS; MORTALITY; EXPOSURE; BEHAVIOR
AB Background: Recent data suggest that vacation may improve cardiovascular health, an effect possibly moderated by altitude. The aim of the present study was to study the effect of a 3-week vacation at moderate and low altitude on perceived health in individuals with increased cardiovascular risk.
   Methods: Seventy-two overweight males, both occupationally active and retired (mean age = 56.6 +/- 7.2 years), with signs of metabolic syndrome were randomly assigned to identical sojourns at either moderate (1,700 m) or low (300 m) altitude and engaged in four 3- to 4-h heart-rate-control led hiking tours per week. Perceived health was measured 2 weeks before vacation, at the beginning and end of vacation, and 7 weeks after vacation.
   Results: Fitness, recreational ability, positive and negative mood and social activities improved during vacation, independent of altitude and occupational status, although the day-to-day improvement in quality of sleep was delayed at moderate altitude. During the follow-up examinations, improvements in all reported aspects of health except for social activities were maintained. In comparison to retired individuals, active individuals showed a greater long-term improvement in social activities.
   Conclusion: Vacation positively affects perceived health independent of altitude or occupational status in generally inactive overweight males.
C1 Ludwig Boltzmann Inst Biol Rhythem Res, Bad Tatzmannsdorf, Austria.
   IHS, Res Inst Leisure & Travel Med, Innsbruck, Austria.
   Leopold Franzens Univ Innsbruck, Clin Anesthesia & Intens Care Med, Innsbruck, Austria.
   Univ Hlth Sci, Inst Leisure Travel & Alpine Med, Innsbruck, Austria.
   Gen Hosp Rankwell, Rankweil, Austria.
   Univ Innsbruck, Clin Anesthesia & Intens Care Med, A-6020 Innsbruck, Austria.
C3 Ludwig Boltzmann Institute; University of Innsbruck; University of
   Innsbruck
RP Univ Vienna, Dept Physiol, Schwarzspanierstr 17, A-1090 Vienna, Austria.
OI Blasche, Gerhard/0000-0002-4779-4843; Fries, Dietmar/0000-0002-1225-4214
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NR 41
TC 25
Z9 29
U1 0
U2 8
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1195-1982
EI 1708-8305
J9 J TRAVEL MED
JI J. Travel Med.
PD SEP-OCT
PY 2004
VL 11
IS 5
BP 300
EP 306
PG 7
WC Public, Environmental & Occupational Health; Infectious Diseases;
   Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; Infectious Diseases;
   General & Internal Medicine
GA 858GX
UT WOS:000224181400006
PM 15544714
OA Bronze
DA 2025-06-11
ER

PT J
AU Datz, C
   Müller, E
   Aigner, E
AF Datz, Christian
   Mueller, Elena
   Aigner, Elmar
TI Iron overload and non-alcoholic fatty liver disease
SO MINERVA ENDOCRINOLOGICA
LA English
DT Review
DE Hepcidins; Iron overload; Metabolic syndrome X; Non-alcoholic fatty
   liver disease
ID CARBOHYDRATE-INTOLERANT PATIENTS; SERUM FERRITIN CONCENTRATION;
   REV-ERB-ALPHA; INSULIN-RESISTANCE; OXIDATIVE STRESS; METABOLIC SYNDROME;
   HEREDITARY HEMOCHROMATOSIS; HEPCIDIN TRANSCRIPTION; HEPATOMA-CELLS;
   CLINICAL-TRIAL
AB Approximately one third of patients with non-alcoholic fatty liver disease (NAFLD) show signs of disturbed iron homeostasis as indicated by elevated serum ferritin with normal or mildly elevated transferrin saturation. Mild hepatic iron deposition is the typical histological finding in these subjects and the term "dysmetabolic iron overload syndrome (DIOS)" is now used to describe this syndrome. From a clinical point of view, excess iron likely aggravates the natural course of NAFLD with regard to liver-related endpoints and extrahepatic disease complications although sound evidence is still lacking. The detrimental effect of iron is attributed to its capability to catalyse the formation of toxic hydroxyl radicals resulting in cellular damage. Conversely, reduction of body iron restores insulin sensitivity, and epidemiological evidence suggests that it delays the onset of complications such as T2DM, cardiovascular disease and also advanced liver disease. Iron accumulation in NAFLD is mainly due to inhibition of iron mobilisation from hepatocytes and Kupffer cells. Impaired iron export is related to inflammation and metabolic derangements that appear to impact on iron regulators, such as hepcidin, ferroportin and to a lesser degree on transferrin receptor, ferritin or copper. This review summarizes the current understanding of the role of iron in NAFLD.
C1 [Datz, Christian] Paracelsus Med Univ, Hosp Oberndorf, Dept Internal Med, Salzburg, Austria.
   [Datz, Christian; Mueller, Elena; Aigner, Elmar] Paracelsus Med Univ, Obes Res Unit, Salzburg, Austria.
   [Aigner, Elmar] Paracelsus Med Univ, Dept Med 1, Salzburg, Austria.
C3 Paracelsus Private Medical University; Paracelsus Private Medical
   University; Paracelsus Private Medical University
RP Aigner, E (corresponding author), Paracelsus Private Med Univ Salzburg, Dept Med 1, Mullner Hauptstr 48, A-5020 Salzburg, Austria.
EM e.aigner@salk.at
FU PMU-Forschungsforderungsfonds [E-13/17/086-AIG]; SPAR Austria
FX Elmar Aigner is supported by PMU-Forschungsforderungsfonds
   (E-13/17/086-AIG). Support from SPAR Austria to Christian Datz is
   gratefully acknowledged.
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NR 91
TC 96
Z9 110
U1 1
U2 24
PU EDIZIONI MINERVA MEDICA
PI TURIN
PA CORSO BRAMANTE 83-85 INT JOURNALS DEPT., 10126 TURIN, ITALY
SN 0391-1977
EI 1827-1634
J9 MINERVA ENDOCRINOL
JI Minerva Endocrinol.
PD JUN
PY 2017
VL 42
IS 2
BP 173
EP 183
DI 10.23736/S0391-1977.16.02565-7
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA FB7QF
UT WOS:000406334400009
PM 27834478
DA 2025-06-11
ER

PT J
AU Saito, M
   Shimazaki, Y
   Yoshii, S
   Takeyama, H
AF Saito, Mizuki
   Shimazaki, Yoshihiro
   Yoshii, Saori
   Takeyama, Hideo
TI Association of self-rated chewing function and oral health status with
   metabolic syndrome
SO JOURNAL OF ORAL SCIENCE
LA English
DT Article
DE chewing function; metabolic syndrome; oral health
ID OXIDATIVE STRESS; OLDER-ADULTS; TOOTH LOSS; PERIODONTITIS; POPULATION;
   PATHOPHYSIOLOGY; ABILITY; DISEASE; NUMBER; TEETH
AB Purpose: The study aimed to examine the association of self-rated chew-ing function, the number of teeth and periodontal status with metabolic syndrome.Methods: The participants were 11,119 adults aged 40-74 years who underwent specific health checkups, including an oral health examination, in 2018 in Japan. This study used the standard questions of the specific health checkups to obtain information on self-rated chewing function. A multinomial logistic regression analysis was performed with metabolic syndrome status as the dependent variable, and age, sex, lifestyle ques-tions, self-rated chewing function, number of teeth, and periodontal status as the independent variables.Results: Number of teeth and periodontal status were significantly associ-ated with metabolic syndrome after adjusting for confounding variables. Self-rated chewing function was significantly associated with metabolic syndrome in the crude analysis, but not after adjustment for confounding variables. Both number of teeth and periodontal status were significantly associated with self-rated chewing function.Conclusion: There was no significant direct association between self-rated chewing function and metabolic syndrome. Self-rated chewing function may be an indicator of poor oral condition that links to metabolic syn-drome.
C1 [Saito, Mizuki; Shimazaki, Yoshihiro] Aichi Gakuin Univ, Sch Dent, Dept Prevent Dent & Dent Publ Hlth, Nagoya, Japan.
   [Yoshii, Saori; Takeyama, Hideo] Aichi Hlth Promot Fdn, Nagoya, Japan.
   [Shimazaki, Yoshihiro] Aichi Gakuin Univ, Sch Dent, Dept Prevent Dent & Dent Publ Hlth, 1-100 Kusumoto cho,Chikusa ku, Nagoya 4648650, Japan.
C3 Aichi Gakuin University; Aichi Gakuin University
RP Shimazaki, Y (corresponding author), Aichi Gakuin Univ, Sch Dent, Dept Prevent Dent & Dent Publ Hlth, 1-100 Kusumoto cho,Chikusa ku, Nagoya 4648650, Japan.
EM shima@dpc.agu.ac.jp
RI YU, Boxuan/AAO-8224-2021
FU JSPS KAKENHI from the Japan Society for the Promotion of Science, Tokyo,
   Japan [19K10429, 22K10353]; Grants-in-Aid for Scientific Research
   [22K10353] Funding Source: KAKEN
FX This work was supported by JSPS KAKENHI Grant Number (No.19K10429 and
   No.22K10353) from the Japan Society for the Promotion of Science, Tokyo,
   Japan.
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NR 40
TC 3
Z9 3
U1 0
U2 4
PU NIHON UNIV, SCHOOL DENTISTRY
PI TOYKO
PA 1--13 KANDA-SURUGADAI, CHIYODA-KU, TOYKO, 101-8310, JAPAN
SN 1343-4934
EI 1880-4926
J9 J ORAL SCI
JI J. Oral Sci.
PD JAN
PY 2023
VL 65
IS 1
BP 29
EP 33
DI 10.2334/josnusd.22-0229
PG 5
WC Dentistry, Oral Surgery & Medicine; Materials Science, Biomaterials
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dentistry, Oral Surgery & Medicine; Materials Science
GA 8D6BI
UT WOS:000918375800007
PM 36529512
OA gold
DA 2025-06-11
ER

PT J
AU Torres, S
   Fabersani, E
   Marquez, A
   Gauffin-Cano, P
AF Torres, Sebastian
   Fabersani, Emanuel
   Marquez, Antonela
   Gauffin-Cano, Paola
TI Adipose tissue inflammation and metabolic syndrome. The proactive role
   of probiotics
SO EUROPEAN JOURNAL OF NUTRITION
LA English
DT Review
DE Metabolic syndrome; Obesity; Chronic low-grade inflammation; Adipose
   tissue; Adipokines; Probiotics
ID HIGH-FAT DIET; LACTOBACILLUS-GASSERI SBT2055; PROMOTE
   INSULIN-RESISTANCE; GUT-MICROBIOTA; INDUCED OBESITY;
   BIFIDOBACTERIUM-LONGUM; ADIPONECTIN LEVELS; OXIDATIVE STRESS;
   GENE-EXPRESSION; ADIPOCYTE SIZE
AB PurposeThe first part of this review focuses on the role of cells and molecules of adipose tissue involved in metabolic syndrome-induced inflammation and in the maintenance of this pathology. In the second part of the review, the potential role of probiotics-modulating metabolic syndrome-related inflammatory components is summarized and discussed.MethodsThe search for the current scientific literature was carried out using ScienceDirect, PubMed, and Google Scholar search engines. The keywords used were: metabolic syndrome, obesity, insulin resistant, adipose tissue, adipose tissue inflammation, chronic low-grade inflammation, immune cells, adipokines, cytokines, probiotics, and gut microbiota. Results and ConclusionsChronic low-grade inflammation that characterized metabolic syndrome can contribute to the development of the metabolic dysfunctions involved in the pathogenesis of its comorbidities. Adipose tissue is a complex organ that performs metabolic and immune functions. During metabolic syndrome, an imbalance in the inflammatory components of adipose tissue (immune cells, cytokines, and adipocytokines), which shift from an anti-inflammatory to a pro-inflammatory profile, can provoke metabolic syndrome linked complications. Further knowledge concerning the immune function of adipose tissue may contribute to finding better alternatives for the treatment or prevention of such disorders. The control of inflammation could result in the management of many of the pathologies related to metabolic syndrome. Due to the strong evidence that gut microbiota composition plays a role modulating the body weight, adipose tissue, and the prevalence of a low-grade inflammatory status, probiotics emerge as valuable tools for the prevention of metabolic syndrome and health recovery.
C1 [Torres, Sebastian] Consejo Nacl Invest Cient & Tecn, Inst Bioprospecc & Fisiol Vegetal INBIOFIV, San Miguel De Tucuman, Argentina.
   [Torres, Sebastian] Univ Nacl Tucuman, Fac Ciencias Nat, San Miguel De Tucuman, Argentina.
   [Torres, Sebastian] Univ Nacl Tucuman, IML, San Miguel De Tucuman, Argentina.
   [Fabersani, Emanuel] Univ Nacl Tucuman, Fac Agron & Zootecnia, San Miguel De Tucuman, Argentina.
   [Marquez, Antonela; Gauffin-Cano, Paola] Consejo Nacl Invest Cient & Tecn, Ctr Referencia Lactobacilos CERELA, Chacabuco 145, RA-4000 San Miguel De Tucuman, Argentina.
C3 Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET);
   Universidad Nacional de Tucuman; Universidad Nacional de Tucuman;
   Universidad Nacional de Tucuman; Consejo Nacional de Investigaciones
   Cientificas y Tecnicas (CONICET)
RP Gauffin-Cano, P (corresponding author), Consejo Nacl Invest Cient & Tecn, Ctr Referencia Lactobacilos CERELA, Chacabuco 145, RA-4000 San Miguel De Tucuman, Argentina.
EM pgauffin@cerela.org.ar
RI Cano, Paola/JRX-6018-2023; Torres, Sebastian/AAE-4510-2020
OI Gauffin-Cano, Paola/0000-0001-9397-6034; Marquez, Maria
   Antonela/0000-0001-9465-618X; TORRES, Sebastian/0000-0002-3593-831X
FU CONICET [PIP215]
FX The present review was supported by the grant PIP215 from CONICET.
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NR 145
TC 129
Z9 139
U1 4
U2 94
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1436-6207
EI 1436-6215
J9 EUR J NUTR
JI Eur. J. Nutr.
PD FEB
PY 2019
VL 58
IS 1
BP 27
EP 43
DI 10.1007/s00394-018-1790-2
PG 17
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA HP6GG
UT WOS:000461781300003
PM 30043184
OA Green Published
DA 2025-06-11
ER

PT J
AU De Vogli, R
   Brunner, E
   Marmot, MG
AF De Vogli, Roberto
   Brunner, Eric
   Marmot, Michael G.
TI Unfairness and the social gradient of metabolic syndrome in the
   Whitehall II study
SO JOURNAL OF PSYCHOSOMATIC RESEARCH
LA English
DT Article
DE metabolic syndrome; unfairness; justice; social class; psychosocial
   factors
ID CORONARY-HEART-DISEASE; MIDDLE-AGED MEN; JOB STRAIN;
   CARDIOVASCULAR-DISEASE; CENTRAL OBESITY; CHRONIC STRESS; RISK; HEALTH;
   INEQUALITY; SUBORDINATE
AB Objectives: Little work has investigated the relationship between unfairness and risk factors for heart disease. We examine the role of unfairness in predicting the metabolic syndrome and explaining the social gradient of the metabolic syndrome. Methods: The design is a prospective study with an average follow-up of 5.8 years. Participants were 4128 males and 1715 females of 20 civil service departments in London (Whitehall 11 study). Sociodemographics, unfairness, employment grade, behavioral risk factors, and other psychosocial factors were measured at baseline (Phase 3, 1991-1993). Waist circumference, triglycerides, high-density lipoprotein (HDL) cholesterol, fasting glucose, and hypertension were used to define metabolic syndrome at follow-up (Phase 5, 1997-2000), according to the National Cholesterol Education Program/Adult Treatment Panel III guidelines. Results: Unfairness is positively associated with waist circumference, hypertension, triglycerides, and fasting glucose and negatively associated with serum HDL cholesterol. High levels of unfairness are also associated with the metabolic syndrome [odds ratio (OR)=1.72, 95% CI=1.31-2.25], after adjustment for age and gender. After additional adjustment for employment grade, behavioral risk factors, and other psychosocial factors, the relationship between high unfairness and metabolic syndrome weakened but remained significant (OR=1.37, 95% CI=1.00-1.93). When adjusting for unfairness, the social gradient of metabolic syndrome was reduced by approximately 10%. Conclusion: Unfairness may be a risk factor for the metabolic syndrome and its components. Future research is needed to study the biological mechanisms linking unfairness and the metabolic syndrome. (c) 2007 Elsevier Inc. All rights reserved.
C1 UCL, Dept Epidemiol & Publ Hlth, Int Inst Soc & Hlth, London WC1E 6BT, England.
C3 University of London; University College London
RP De Vogli, R (corresponding author), UCL, Dept Epidemiol & Publ Hlth, Int Inst Soc & Hlth, 1-19 Torrington Pl, London WC1E 6BT, England.
EM r.devogli@uci.ac.uk
RI Brunner, Eric/H-2114-2011; Marmot, Michael/Y-3920-2019
OI Marmot, Michael/0000-0002-2431-6419; Brunner, Eric/0000-0002-0595-4474
FU AHRQ HHS [HS06516] Funding Source: Medline; British Heart Foundation
   [RG/07/008/23674] Funding Source: Medline; Medical Research Council
   [G8802774, G0100222, G19/35] Funding Source: Medline; NHLBI NIH HHS
   [HL36310] Funding Source: Medline; NIA NIH HHS [AG13196] Funding Source:
   Medline
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PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-3999
J9 J PSYCHOSOM RES
JI J. Psychosomat. Res.
PD OCT
PY 2007
VL 63
IS 4
BP 413
EP 419
DI 10.1016/j.jpsychores.2007.04.006
PG 7
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 219WY
UT WOS:000250120100011
PM 17905050
DA 2025-06-11
ER

PT J
AU Araujo, DS
   Marquezin, MCS
   Barbosa, TS
   Fonseca, FLA
   Fegadolli, C
   Castelo, PM
AF Araujo, D. S.
   Marquezin, M. C. S.
   Barbosa, T. S.
   Fonseca, F. L. A.
   Fegadolli, C.
   Castelo, P. M.
TI Assessment of quality of life, anxiety, socio-economic factors and
   caries experience in Brazilian children with overweight and obesity
SO INTERNATIONAL JOURNAL OF DENTAL HYGIENE
LA English
DT Article
DE anthropometry; child; obesity; quality of life; socio-economic factors
ID DENTAL-CARIES; METABOLIC SYNDROME; UNITED-STATES; ADOLESCENTS;
   CHILDHOOD; HEALTH; PREVALENCE; ASSOCIATIONS; DEPRESSION; SCALE
AB Purpose: This study evaluated the association between excess weight and quality of life (QoL), symptoms of anxiety, caries experience and socio-economic factors in a representative sample of 8- to 10-year-old children from three public schools of Piracicaba (SP, Brazil). Materials and methods: The Autoquestionnaire Qualite de Vie Enfant Image was applied to explore family and social relations, activities, health, body functions and separation domains, and, by means of the Multidimensional Anxiety Scale for Children, symptoms of anxiety were screened. Clinical examination was performed using DMFT/dmft indexes to assess oral health and caries experience. Medical and nutritional history, parents' schooling, monthly income and ownership of household goods and services were also evaluated. Results: Of the 313 subjects included, four subjects were underweight, 188 normal weight, 67 overweight and 54 presented obesity (38.7% with excess weight). Measures of QoL, anxiety scores and caries experience did not differ between groups. The regression model showed a significant association between excess weight and the ownership of household goods and services (OR = 5.4/CI = 1.6-18.3). Conclusions: High prevalence of excess weight was observed among prepubertal children, emphasizing the need for continued health programmes to limit risk factors for obesity. QoL, anxiety scores and caries experience did not differ between subjects with different body weights, although children from public schools with higher ownership of goods and services were more likely to present excess weight.
C1 [Araujo, D. S.; Marquezin, M. C. S.; Barbosa, T. S.] Univ Estadual Campinas, Dept Pediat Dent, Piracicaba Dent Sch, Piracicaba, SP, Brazil.
   [Fonseca, F. L. A.; Fegadolli, C.; Castelo, P. M.] Univ Fed Sao Paulo, Dept Biol Sci, Diadema, SP, Brazil.
C3 Universidade Estadual de Campinas; Universidade Federal de Sao Paulo
   (UNIFESP)
RP Castelo, PM (corresponding author), Univ Fed Sao Paulo UNIFESP, Dept Ciencias Biol, R Sao Nicolau 210,1 Andar, BR-09913030 Diadema, SP, Brazil.
EM pcastelo@yahoo.com
RI Barbosa, Tais/A-2241-2013; Fegadolli, Claudia/AAE-4859-2019; Castelo,
   Paula Midori/I-6922-2012
OI Barbosa, Tais/0000-0002-3479-7789; Castelo, Paula
   Midori/0000-0001-8703-2272
FU State of Sao Paulo Research Foundation (FAPESP, Brazil) [2011/15621-5,
   2012/04492-2]; Fundacao de Amparo a Pesquisa do Estado de Sao Paulo
   (FAPESP) [11/15621-5] Funding Source: FAPESP
FX This study received financial support from the State of Sao Paulo
   Research Foundation (FAPESP, Brazil), Grants Nos. 2011/15621-5 and
   2012/04492-2.
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NR 41
TC 11
Z9 13
U1 0
U2 15
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1601-5029
EI 1601-5037
J9 INT J DENT HYG
JI Int. J. Dent. Hyg.
PD NOV
PY 2017
VL 15
IS 4
BP e156
EP e162
DI 10.1111/idh.12248
PG 7
WC Dentistry, Oral Surgery & Medicine
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dentistry, Oral Surgery & Medicine
GA FK5JE
UT WOS:000413533400020
PM 27699998
DA 2025-06-11
ER

PT J
AU Ming, Z
   Legare, DJ
   Lautt, WW
AF Ming, Zhi
   Legare, Dallas J.
   Lautt, W. Wayne
TI Absence of meal-induced insulin sensitization (AMIS) in aging rats is
   associated with cardiac dysfunction that is protected by antioxidants
SO JOURNAL OF APPLIED PHYSIOLOGY
LA English
DT Article
DE age; HISS-dependent insulin sensitivity; cardiac dysfunction; metabolic
   syndrome
ID PRESSURE-VOLUME RELATIONSHIPS; HIGH-FRUCTOSE DIET; METABOLIC SYNDROME;
   SYNDROME-X; VASCULAR DYSFUNCTION; HISS HYPOTHESIS; RISK-FACTORS;
   RESISTANCE; AGE; SUCROSE
AB Ming Z, Legare DJ, Lautt WW. Absence of meal-induced insulin sensitization (AMIS) in aging rats is associated with cardiac dysfunction that is protected by antioxidants. J Appl Physiol 111: 704-714, 2011. First published May 26, 2011; doi: 10.1152/japplphysiol.00057.2011.-We have previously demonstrated that progressive development of absence of meal-induced insulin sensitization (AMIS) leads to postprandial hyperglycemia, compensatory hyperinsulinemia, resultant hyperlipidemia, increased oxidative stress, and obesity, progressing to syndrome X in aging rats. The present study tested the hypothesis that progressive development of AMIS in aging rats further resulted in deterioration in cardiac performance. Anesthetized male Sprague-Dawley rats were tested at 9, 26, and 52 wk to determine their dynamic response to insulin and cardiac function. Dynamic insulin sensitivity was determined before and after atropine to quantitate hepatic insulin sensitizing substance (HISS)-dependent and -independent insulin action. Cardiac performance was evaluated using a Millar pressure-volume conductance catheter system. AMIS developed with age, as demonstrated by significant decrease in HISS-dependent insulin action, and this syndrome was increased by sucrose supplementation and inhibited by the antioxidant treatment. Associated with progressive development of AMIS, aging rats showed impaired cardiac performance, including the reduction in cardiac index, heart rate, dP/dt(max), dP/dt(min), ejection fraction and decreased slope of left ventricular end-systolic pressure-volume relationship, and increased relaxation time constant of left ventricular pressure as well as increased left ventricular end-diastolic pressure. Total peripheral vascular resistance also increased with age. Sucrose supplementation and antioxidant treatment, respectively, potentiated and attenuated cardiac dysfunction associated with age. In addition, poor cardiac performance correlated closely with the development of AMIS. These results indicate that AMIS is the first metabolic defect that leads to homeostatic disturbances and dysfunctions, including cardiovascular diseases.
C1 [Ming, Zhi; Legare, Dallas J.; Lautt, W. Wayne] Univ Manitoba, Fac Med, Dept Pharmacol & Therapeut, Winnipeg, MB R3E 0T6, Canada.
   [Lautt, W. Wayne] Univ Manitoba, Fac Med, Ctr Aging, Winnipeg, MB R3E 0T6, Canada.
C3 University of Manitoba; University of Manitoba
RP Lautt, WW (corresponding author), Univ Manitoba, Fac Med, Dept Pharmacol & Therapeut, A210-753 McDermot Ave, Winnipeg, MB R3E 0T6, Canada.
EM wlautt@cc.umanitoba.ca
RI Legare, Dallas/AAC-3234-2021; Lautt, W./AAC-6106-2021
OI Lautt, W. Wayne/0000-0002-7239-1798
FU Canadian Institutes of Health Research [FRN-82037, FRN-84533]; Manitoba
   Health Research Council; Canadian Liver Foundation; Canadian Diabetes
   Association
FX This study was funded by operating grants from the Canadian Institutes
   of Health Research (FRN-82037 and FRN-84533) and the Manitoba Health
   Research Council Regional Partnership Program, the Canadian Liver
   Foundation, and the Canadian Diabetes Association.
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NR 47
TC 10
Z9 12
U1 0
U2 6
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 8750-7587
J9 J APPL PHYSIOL
JI J. Appl. Physiol.
PD SEP
PY 2011
VL 111
IS 3
BP 704
EP 714
DI 10.1152/japplphysiol.00057.2011
PG 11
WC Physiology; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology; Sport Sciences
GA 817QM
UT WOS:000294688900010
PM 21617079
DA 2025-06-11
ER

PT J
AU Ekelund, U
   Brage, S
   Franks, PW
   Hennings, S
   Emms, S
   Wareham, NJ
AF Ekelund, U
   Brage, S
   Franks, PW
   Hennings, S
   Emms, S
   Wareham, NJ
TI Physical activity energy expenditure predicts progression toward the
   metabolic syndrome independently of aerobic fitness in middle-aged
   healthy Caucasians - The Medical Research Council Ely Study
SO DIABETES CARE
LA English
DT Article
ID BIOELECTRICAL-IMPEDANCE ANALYSIS; DOUBLY LABELED WATER;
   CARDIORESPIRATORY FITNESS; DIABETES-MELLITUS; HEART-RATE; ASSOCIATION;
   CHILDREN; SIZE
AB OBJECTIVE - To examine over a period of 5.6 years the prospective associations between physical activity energy expenditure (PAEE), aerobic fitness (VO2max), obesity, and the progression toward the metabolic syndrome in a population-based cohort of middle-aged men and women (n = 605) who were free of the metabolic syndrome at baseline.
   RESEARCH DESIGN AND METHODS - PAEE was measured objectively by individually calibrated heart rite against energy expenditure. VO2max was predicted from a submaximal exercise Stress test. Fat mass and fat-free mass were assessed by bio-impedance. A metabolic syndrome score was computed by summing the standardized values for obesity, hypertension, hyperglycemia, insulin resistance, hypetyriglyceridemia, and the inverse level of HDL-cholesterol and expressed as a continuously distributed outcome. Generalized linear models were used to examine the independent prospective associations between PAEE and Vo(2max) and the metabolic Syndrome score after adjusting for sex, baseline age, smoking, Socioeconomic status, follow-up time, and baseline phenotypes.
   RESULTS - PAEE predicted progression toward the metabolic syndrome, independent of baseline metabolic syndrome, body fat, VO2max, and other confounding factors (standardized beta = -0.00085, P = 0.046). This association was stronger when excluding the adiposity component from the metabolic syndrome (standardized beta = -0.0011, P = 0.035). Vo(2max) was not an independent predictor of the metabolic syndrome after adjusting for physical activity (standardized beta =0.00011, P = 0.93).
   CONCLUSIONS - PAEE predicts progression toward the metabolic syndrome independent of aerobic fitness, obesity, and other confounding factors. This finding underscores the importance of physical activity for metabolic disease prevention even when an improvement in aerobic fitness is absent.
C1 MRC, Elsie Widdowson Lab, Epidemiol Unit, Cambridge CB1 9NL, England.
C3 UK Research & Innovation (UKRI); Medical Research Council UK (MRC); MRC
   Human Nutrition Research
RP MRC, Elsie Widdowson Lab, Epidemiol Unit, Fulbourn Rd, Cambridge CB1 9NL, England.
EM ue202@medschl.cam.ac.uk
RI Ekelund, Ulf/A-1046-2008; Timpson, Nicholas/O-7548-2015; Franks,
   Paul/AAA-3300-2020; Brage, Soren/C-6415-2013
OI Franks, Paul/0000-0002-0520-7604; Brage, Soren/0000-0002-1265-7355
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NR 22
TC 157
Z9 181
U1 0
U2 14
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0149-5992
EI 1935-5548
J9 DIABETES CARE
JI Diabetes Care
PD MAY
PY 2005
VL 28
IS 5
BP 1195
EP 1200
DI 10.2337/diacare.28.5.1195
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 920OX
UT WOS:000228701100033
PM 15855588
OA Bronze
DA 2025-06-11
ER

PT S
AU Laugero, KD
AF Laugero, KD
BE Litwack, G
TI Reinterpretation of basal glucocorticoid feedback: Implications to
   behavioral and metabolic disease
SO VITAMINS AND HORMONES - ADVANCES IN RESEARCH AND APPLICATIONS, VOL 69
SE Vitamins and Hormones
LA English
DT Review
ID PITUITARY-ADRENAL AXIS; CORTICOTROPIN-RELEASING-HORMONE; DIFFERENT BRAIN
   SITES; MINERALOCORTICOID RECEPTOR; ADRENALECTOMIZED RATS; MESSENGER-RNA;
   ENERGY-BALANCE; HPA AXIS; ADRENOCORTICOTROPIN SECRETION; CORTICOSTEROID
   RECEPTORS
AB A number of metabolic (e.g., abdominal obesity) and psychological (e.g., depression) pathologies commonly present together and have been associated with dysregulation in the hypothalamo-pituitary-adrenal (HPA) axis. Glucocorticoid hormones represent the final product of this classic neuroendocrine axis, and these steroids modulate neuroendocrine, metabolic, and behavioral function. A primary characteristic of the HPA axis is a negative feedback loop, and glucocorticoids act through the brain to inhibit drive to this neuroendocrine system. Slight and chronic perturbations in glucocorticoid levels, below or above normal, throughout the body lead to metabolic (e.g., abdominal obesity) and behavioral (e.g., depression) pathology. Appropriate feedback in the HPA axis is, therefore, critical, and determining how and where glucocorticoids act to impart their feedback effects have been the focus of many laboratories. However, the answer to these questions remain, in part, elusive. In this chapter, I review findings that have led me to reinterpret glucocorticoid feedback in the HPA axis. I propose that, under basal (nonstress) conditions, glucocorticoid feedback is a consequence of the metabolic actions of the adrenal steroid, not a direct effect on brain. This new perspective may provide insight into the etiology of diseases such as major depression and the metabolic syndrome X, and might explain the commonly observed coexistence of affective and metabolic disturbances. (C) 2004 Elsevier Inc.
C1 Univ Calif San Francisco, Sch Med, Dept Physiol, San Francisco, CA 94143 USA.
C3 University of California System; University of California San Francisco
RP Univ Calif San Francisco, Sch Med, Dept Physiol, San Francisco, CA 94143 USA.
FU NIDDK NIH HHS [DK-59735] Funding Source: Medline
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NR 122
TC 12
Z9 15
U1 0
U2 3
PU ELSEVIER ACADEMIC PRESS INC
PI SAN DIEGO
PA 525 B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0083-6729
BN 0-12-709869-0
J9 VITAM HORM
JI Vitam. Horm.
PY 2004
VL 69
BP 1
EP 29
DI 10.1016/S0083-6729(04)69001-7
PG 29
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA BAR08
UT WOS:000223227200001
PM 15196877
DA 2025-06-11
ER

PT J
AU Sárközy, M
   Zvara, A
   Gyémánt, N
   Fekete, V
   Kocsis, GF
   Pipis, J
   Szucs, G
   Csonka, C
   Puskás, LG
   Ferdinandy, P
   Csont, T
AF Sarkoezy, Marta
   Zvara, Agnes
   Gyemant, Nora
   Fekete, Veronika
   Kocsis, Gabriella F.
   Pipis, Judit
   Szucs, Gergo
   Csonka, Csaba
   Puskas, Laszlo G.
   Ferdinandy, Peter
   Csont, Tamas
TI Metabolic syndrome influences cardiac gene expression pattern at the
   transcript level in male ZDF rats
SO CARDIOVASCULAR DIABETOLOGY
LA English
DT Article
DE Metabolic syndrome; Diabetes mellitus type 2; Hyperlipidemia;
   Myocardium; DNA microarray; Heart; GO analysis
ID CORONARY-HEART-DISEASE; DIABETIC FATTY RATS; INSULIN-RESISTANCE;
   CARDIOVASCULAR-DISEASE; NITROSATIVE STRESS; ARGININOSUCCINATE SYNTHASE;
   ENDOTHELIAL DYSFUNCTION; LIVER DYSFUNCTION; OXIDATIVE STRESS; RESPONSE
   ELEMENT
AB Background: Metabolic syndrome (coexisting visceral obesity, dyslipidemia, hyperglycemia, and hypertension) is a prominent risk factor for cardiovascular morbidity and mortality, however, its effect on cardiac gene expression pattern is unclear. Therefore, we examined the possible alterations in cardiac gene expression pattern in male Zucker Diabetic Fatty (ZDF) rats, a model of metabolic syndrome.
   Methods: Fasting blood glucose, serum insulin, cholesterol and triglyceride levels were measured at 6, 16, and 25 wk of age in male ZDF and lean control rats. Oral glucose tolerance test was performed at 16 and 25 wk of age. At week 25, total RNA was isolated from the myocardium and assayed by rat oligonucleotide microarray for 14921 genes. Expression of selected genes was confirmed by qRT-PCR.
   Results: Fasting blood glucose, serum insulin, cholesterol and triglyceride levels were significantly increased, glucose tolerance and insulin sensitivity were impaired in ZDF rats compared to leans. In hearts of ZDF rats, 36 genes showed significant up-regulation and 49 genes showed down-regulation as compared to lean controls. Genes with significantly altered expression in the heart due to metabolic syndrome includes functional clusters of metabolism (e.g. 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2; argininosuccinate synthetase; 2-amino-3ketobutyrate-coenzyme A ligase), structural proteins (e.g. myosin IXA; aggrecan1), signal transduction (e. g. activating transcription factor 3; phospholipase A2; insulin responsive sequence DNA binding protein-1) stress response (e.g. heat shock 70kD protein 1A; heat shock protein 60; glutathione S-transferase Yc2 subunit), ion channels and receptors (e.g. ATPase, (Na+)/K+ transporting, beta 4 polypeptide; ATPase, H+/K+ transporting, nongastric, alpha polypeptide). Moreover some other genes with no definite functional clusters were also changed such as e. g. S100 calcium binding protein A3; ubiquitin carboxy-terminal hydrolase L1; interleukin 18. Gene ontology analysis revealed several significantly enriched functional inter-relationships between genes influenced by metabolic syndrome.
   Conclusions: Metabolic syndrome significantly alters cardiac gene expression profile which may be involved in development of cardiac pathologies in the presence of metabolic syndrome.
C1 [Sarkoezy, Marta; Gyemant, Nora; Fekete, Veronika; Kocsis, Gabriella F.; Pipis, Judit; Szucs, Gergo; Csonka, Csaba; Csont, Tamas] Univ Szeged, Fac Med, Dept Biochem, Cardiovasc Res Grp, Szeged, Hungary.
   [Zvara, Agnes; Puskas, Laszlo G.] Biol Res Ctr, Dept Funct Genom, H-6701 Szeged, Hungary.
   [Pipis, Judit; Csonka, Csaba; Ferdinandy, Peter; Csont, Tamas] Pharmahungary Grp, Szeged, Hungary.
   [Ferdinandy, Peter] Semmelweis Univ, Fac Med, Dept Pharmacol & Pharmacotherapy, Budapest, Hungary.
C3 Szeged University; HUN-REN; HUN-REN Biological Research Center;
   Pharmahungary Group; Semmelweis University
RP Csont, T (corresponding author), Univ Szeged, Fac Med, Dept Biochem, Cardiovasc Res Grp, Szeged, Hungary.
EM csont.tamas@med.u-szeged.hu
RI Szűcs, Gergő/O-8732-2019; Ferdinandy, Péter/H-9181-2019; Sarkozy,
   Marta/G-1657-2016
OI Csonka, Csaba/0000-0003-2532-6261; Szucs, Gergo/0000-0003-1874-2718;
   Sarkozy, Marta/0000-0002-5929-2146
FU National Development Agency (MED_FOOD) [DA-TECH-07-2008-0041,
   TAMOP-4.2.1/B-09/1/KONV-2010-0005, TAMOP-4.2.2/B-10/1-2010-0012];
   Hungarian Scientific Research Fund [OTKA K79167]; European Regional
   Development Fund; VATI Hungarian Nonprofit Limited Liability Company for
   Regional Development and Town Planning
   [HURO/0901/137/2.2.2-HU-RO-TRANS-MED]; Hungarian Academy of Sciences
FX This work was supported by grants from the National Development Agency
   (MED_FOOD, Baross DA-TECH-07-2008-0041;
   TAMOP-4.2.1/B-09/1/KONV-2010-0005; and TAMOP-4.2.2/B-10/1-2010-0012),
   the Hungarian Scientific Research Fund (OTKA K79167), and co-financed by
   the European Regional Development Fund and VATI Hungarian Nonprofit
   Limited Liability Company for Regional Development and Town Planning
   (HURO/0901/137/2.2.2-HU-RO-TRANS-MED). T. Csont and A. Zvara hold a
   "Janos Bolyai Felowship" from the Hungarian Academy of Sciences.
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NR 95
TC 51
Z9 58
U1 0
U2 39
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1475-2840
J9 CARDIOVASC DIABETOL
JI Cardiovasc. Diabetol.
PD JAN 15
PY 2013
VL 12
AR 16
DI 10.1186/1475-2840-12-16
PG 17
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism
GA 108FW
UT WOS:000316278200001
PM 23320804
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Feig, DI
   Kang, DH
   Johnson, RJ
AF Feig, Daniel I.
   Kang, Duk-Hee
   Johnson, Richard J.
TI Uric acid and cardiovascular risk
SO NEW ENGLAND JOURNAL OF MEDICINE
LA English
DT Review
ID CORONARY-HEART-DISEASE; MUSCLE-CELL-PROLIFERATION; SALT-SENSITIVE
   HYPERTENSION; BLOOD-PRESSURE; ENDOTHELIAL FUNCTION; OXIDATIVE STRESS;
   METABOLIC SYNDROME; ATHEROSCLEROSIS RISK; RENAL-FUNCTION; SERUM URATE
C1 [Feig, Daniel I.] Baylor Coll Med, Dept Pediat, Coll Med, Renal Sect, Houston, TX 77030 USA.
   [Kang, Duk-Hee] Ewha Womans Univ, Sch Med, Seoul, South Korea.
   [Johnson, Richard J.] Univ Colorado, Hlth Sci Ctr, Denver, CO USA.
C3 Baylor College of Medicine; Ewha Womans University; University of
   Colorado System; University of Colorado Denver; University of Colorado
   Anschutz Medical Campus
RP Feig, DI (corresponding author), Baylor Coll Med, Dept Pediat, Coll Med, Renal Sect, Houston, TX 77030 USA.
EM dfeig@bcm.tmc.edu
OI Johnson, Richard/0000-0003-3312-8193; Feig, Daniel/0000-0002-0017-6335
FU U.S. Public Health Service [HL-68607, DK-52121, DK064587]; Korea Science
   and Engineering Foundation through the government of Korea, Ministry of
   Education, Science, and Technology [R01-2008-000-10845-0]
FX Supported by grants from the U.S. Public Health Service (HL-68607 and
   DK-52121, to Dr. Johnson; and DK064587, to Dr. Feig) and from the Korea
   Science and Engineering Foundation through the government of Korea,
   Ministry of Education, Science, and Technology (R01-2008-000-10845-0, to
   Dr. Kang). Dr. Johnson reports being listed as an inventor on several
   patent applications related to the role of uric acid in hypertension and
   the metabolic syndrome and being an author of The Sugar Fix, a book for
   the lay public on fructose and uric acid published by Rodale in 2008. No
   other potential conflict of interest relevant to this article was
   reported.
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NR 130
TC 1892
Z9 2063
U1 13
U2 245
PU MASSACHUSETTS MEDICAL SOC
PI WALTHAM
PA WALTHAM WOODS CENTER, 860 WINTER ST,, WALTHAM, MA 02451-1413 USA
SN 0028-4793
EI 1533-4406
J9 NEW ENGL J MED
JI N. Engl. J. Med.
PD OCT 23
PY 2008
VL 359
IS 17
BP 1811
EP 1821
DI 10.1056/NEJMra0800885
PG 11
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 363DJ
UT WOS:000260245800008
PM 18946066
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Dimopoulos, N
   Piperi, C
   Salonicioti, A
   Mitsonis, C
   Liappas, L
   Lea, RW
   Kalofoutis, A
AF Dimopoulos, Nikolaos
   Piperi, Christina
   Salonicioti, Aristea
   Mitsonis, Charalampos
   Liappas, Loannis
   Lea, Robert W.
   Kalofoutis, Anastasios
TI Elevation of plasma concentration of adhesion molecules in late-life
   depression
SO INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
LA English
DT Article
DE adhesion molecules; VCAM-1; ICAM-1; depression; elderly
ID CYTOKINES; SYMPTOMS; DISORDER; STRESS
AB Objectives Late-life depression may be associated with vascular disease. The purpose of the study was to investigate this association by determining the levels of soluble adhesion molecules (sICAM-1 and sVCAM-1) which represent markers of ischemia-induced inflammation in elderly individuals with depression.
   Methods Blood samples were obtained from 33 subjects with depression selected from a community-dwelling population after screening with the Geriatric Depression Scale, and 33 matched controls. Serum concentrations of slCAM-1 (ng/mL) and sVCAM-1 (ng/mL) were measured in both groups.
   Results Depressed patients (Group A) possessed significantly higher sICAM-1 levels compared to healthy controls (Group B) (674.94 +/- 166.90 ng/ml vs 467.05 +/- 231.26 ng/ml, respectively, p < 0.01). Similarly the same groups demonstrated elevated sVCAM-1 levels compared to controls (572.14 +/- 182.20 ng/ml vs 449.04 +/- 285.27 ng/ml, p < 0.05); a difference that in both cases remained significant after adjustment for potential confounders (gender, smoking, presence of metabolic syndrome).
   Conclusion These findings indicate an association between high serum levels of VCAM-1, and ICAM-1 and depression in the elderly and further support the vascular depression hypothesis, which has important implications for the understanding and management of late-life depression. Copyright (c) 2006 John Wiley & Sons, Ltd.
C1 Univ Athens, Sch Med, Biol Chem Lab, GR-11527 Athens, Greece.
   Ctr Hlth, Athens, Greece.
   Hosp Psychiat, Athens, Greece.
   Univ Athens, Sch Med, Dept Psychiat, Eginit Hosp, GR-11527 Athens, Greece.
   Univ Cent Lancashire, Dept Biol Sci, Preston PR1 2HE, Lancs, England.
C3 National & Kapodistrian University of Athens; Athens Medical School;
   National & Kapodistrian University of Athens; Athens Medical School;
   University of Central Lancashire
RP Piperi, C (corresponding author), Univ Athens, Sch Med, Biol Chem Lab, M Asias 75, GR-11527 Athens, Greece.
EM cpiperi@med.uoa.gr
RI Piperi, Christina/AAF-2009-2020
OI Piperi, Christina/0000-0002-2701-0618
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NR 34
TC 43
Z9 46
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0885-6230
EI 1099-1166
J9 INT J GERIATR PSYCH
JI Int. J. Geriatr. Psychiatr.
PD OCT
PY 2006
VL 21
IS 10
BP 965
EP 971
DI 10.1002/gps.1592
PG 7
WC Geriatrics & Gerontology; Gerontology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Psychiatry
GA 101AW
UT WOS:000241712300009
PM 16927406
DA 2025-06-11
ER

PT J
AU Kunutsor, SK
   Lehoczki, A
   Laukkanen, JA
AF Kunutsor, Setor K.
   Lehoczki, Andrea
   Laukkanen, Jari A.
TI The untapped potential of cold water therapy as part of a lifestyle
   intervention for promoting healthy aging
SO GEROSCIENCE
LA English
DT Review; Early Access
DE Hydrotherapy; Cold water therapy; Cardiovascular disease; Mortality;
   Healthspan
ID WHOLE-BODY CRYOTHERAPY; ONSET MUSCLE SORENESS; CAENORHABDITIS-ELEGANS;
   INSULIN SENSITIVITY; ADIPOSE-TISSUE; FINNISH SAUNA; FATTY-ACIDS;
   TEMPERATURE; IMMERSION; RECOVERY
AB Healthy aging is a crucial goal in aging societies of the western world, with various lifestyle strategies being employed to achieve it. Among these strategies, hydrotherapy stands out for its potential to promote cardiovascular and mental health. Cold water therapy, a hydrotherapy technique, has emerged as a lifestyle strategy with the potential capacity to evoke a wide array of health benefits. This review aims to synthesize the extensive body of research surrounding cold water therapy and its beneficial effects on various health systems as well as the underlying biological mechanisms driving these benefits. We conducted a search for interventional and observational cohort studies from MEDLINE and EMBASE up to July 2024. Deliberate exposure of the body to cold water results in distinct physiological responses that may be linked to several health benefits. Evidence, primarily from small interventional studies, suggests that cold water therapy positively impacts cardiometabolic risk factors, stimulates brown adipose tissue and promotes energy expenditure-potentially reducing the risk of cardiometabolic diseases. It also triggers the release of stress hormones, catecholamines and endorphins, enhancing alertness and elevating mood, which may alleviate mental health conditions. Cold water therapy also reduces inflammation, boosts the immune system, promotes sleep and enhances recovery following exercise. The optimal duration and temperature needed to derive maximal benefits is uncertain but current evidence suggests that short-term exposure and lower temperatures may be more beneficial. Overall, cold water therapy presents a potential lifestyle strategy to enhancing physical and mental well-being, promoting healthy aging and extending the healthspan, but definitive interventional evidence is warranted.
C1 [Kunutsor, Setor K.] Univ Manitoba, Dept Internal Med, Sect Cardiol, Max Rady Coll Med,Rady Fac Hlth Sci, Winnipeg, MB R2H 2A6, Canada.
   [Kunutsor, Setor K.] Univ Leicester, Leicester Gen Hosp, Diabet Res Ctr, Leicester Real World Evidence Unit, Gwendolen Rd, Leicester LE5 4WP, England.
   [Lehoczki, Andrea] Semmelweis Univ, Dept Prevent Med & Publ Hlth, Budapest, Hungary.
   [Laukkanen, Jari A.] Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland.
   [Laukkanen, Jari A.] Univ Eastern Finland, Inst Clin Med, Dept Med, Kuopio, Finland.
   [Laukkanen, Jari A.] Wellbeing Serv Cty Cent Finland, Dept Med, Jyvaskyla, Finland.
C3 University of Manitoba; University Hospitals of Leicester NHS Trust;
   Leicester General Hospital; University of Leicester; Semmelweis
   University; University of Eastern Finland; University of Eastern Finland
RP Kunutsor, SK (corresponding author), Univ Manitoba, Dept Internal Med, Sect Cardiol, Max Rady Coll Med,Rady Fac Hlth Sci, Winnipeg, MB R2H 2A6, Canada.; Kunutsor, SK (corresponding author), Univ Leicester, Leicester Real World Evidence Unit, Leicester Gen Hosp, Diabet Res Ctr, Gwendolen Rd, Leicester LE5 4WP, England.
EM skk31@cantab.net
RI Kunutsor, Setor/H-9807-2019; Laukkanen, Jari/N-2196-2019; Lehoczki,
   Andrea/LQK-7571-2024
OI KUNUTSOR, SETOR/0000-0002-2625-0273
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PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 2509-2715
EI 2509-2723
J9 GEROSCIENCE
JI GeroScience
PD 2024 JUL 30
PY 2024
DI 10.1007/s11357-024-01295-w
EA JUL 2024
PG 21
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA A2C7K
UT WOS:001280668400001
PM 39078461
DA 2025-06-11
ER

PT J
AU Lee, YJ
   Nam, GE
   Seo, JA
   Yoon, T
   Seo, I
   Lee, JH
   Im, D
   Bahn, KN
   Jeong, SA
   Kang, TS
   Ahn, JH
   Kim, DH
   Kim, NH
AF Lee, Young Joo
   Nam, Ga Eun
   Seo, Ji A.
   Yoon, Taehyung
   Seo, Ilwon
   Lee, Jin Hee
   Im, Donggil
   Bahn, Kyeong-Nyeo
   Jeong, Si An
   Kang, Tae Sea
   Ahn, Jae Hee
   Kim, Do Hoon
   Kim, Nan Hee
TI Nut consumption has favorable effects on lipid profiles of Korean women
   with metabolic syndrome
SO NUTRITION RESEARCH
LA English
DT Article
DE Nuts; Metabolic syndrome; Lipid profile; Inflammation; Oxidative stress;
   Endothelial function
ID MEDITERRANEAN DIET; RISK; METAANALYSIS; BIOMARKERS; COMPONENTS; MARKERS;
   ALMONDS; WEIGHT; WALNUT; HEALTH
AB Nut consumption has been studied for its cardioprotective effects. However, the findings of clinical intervention studies are inconsistent; and no intervention studies have been conducted in the Korean population. We hypothesized that nut supplementation may have favorable influence on metabolic markers. Therefore, this study aimed to investigate the effects of nut consumption on metabolic parameters and biomarkers related to inflammation, oxidative stress, and endothelial function in Korean adults with metabolic syndrome. To this end, we designed a randomized, parallel, controlled dietary intervention study (ClinicalTrials.gov NCT02023749). Subjects with metabolic syndrome and a body mass index of at least 23 kg/m(2) were randomized to the Control group and the Nut group, which received supplementation with 30 g/d of mixed nuts (walnuts, peanuts, and pine nuts) for 6 weeks. Sixty volunteers were included in the final analysis. Metabolic markers were evaluated at baseline and at the end of the study. Total cholesterol and non high-density lipoprotein cholesterol levels significantly improved in the Nut group compared to those in the Control group (P = .023 and P = .016, respectively) in women. Biomarkers related to inflammation, oxidative stress, and endothelial function did not significantly change from baseline in either group. Thus, supplementing a usual diet with mixed nuts for 6 weeks had favorable effects on several lipid parameters in Korean women with metabolic syndrome. These findings present a possible mechanism for the cardioprotective effects of nut consumption. (C) 2014 Elsevier Inc. All rights reserved.
C1 [Lee, Young Joo; Yoon, Taehyung; Seo, Ilwon; Lee, Jin Hee; Im, Donggil; Bahn, Kyeong-Nyeo; Jeong, Si An; Kang, Tae Sea] Natl Inst Food & Drug Safety Evaluat, Nutr & Funct Food Res Team, Chungcheongbuk Do, South Korea.
   [Nam, Ga Eun; Kim, Do Hoon] Korea Univ, Ansan Hosp, Coll Med, Dept Family Med, Ansan, South Korea.
   [Seo, Ji A.; Ahn, Jae Hee; Kim, Nan Hee] Korea Univ, Ansan Hosp, Coll Med, Dept Endocrinol & Metab, Ansan, South Korea.
C3 Ministry of Food & Drug Safety (MFDS), Republic of Korea; National
   Institute of Food & Drug Safety Evaluation; Korea University; Korea
   University Medicine (KU Medicine); Korea University; Korea University
   Medicine (KU Medicine)
RP Nam, GE (corresponding author), Korea Univ, Ansan Hosp, Coll Med, Dept Family Med, 516 Gojan Dong, Ansan 425707, Gyeonggi Do, South Korea.
EM namgaaa@hanmail.net; nhkendo@gmail.com
RI Kim, Nan/T-8627-2019; SEO, JI/AAU-7968-2020; Nam, Ga Eun/AAU-6055-2020;
   SEO, JI A/C-6623-2018
OI SEO, JI A/0000-0002-1927-2618; Kim, Nan Hee/0000-0003-4378-520X; Kim, Do
   Hoon/0000-0001-7421-4501; Nam, Ga Eun/0000-0002-6739-9904
FU Ministry of Food and Drug Safety [12161MFDS118]
FX This research was supported by a grant (12161MFDS118) from the Ministry
   of Food and Drug Safety in 2012. The authors declare no conflicts of
   interest.
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NR 31
TC 50
Z9 54
U1 0
U2 17
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0271-5317
J9 NUTR RES
JI Nutr. Res.
PD SEP
PY 2014
VL 34
IS 9
BP 814
EP 820
DI 10.1016/j.nutres.2014.08.011
PG 7
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA AQ3TR
UT WOS:000342716900010
PM 25238912
DA 2025-06-11
ER

PT J
AU Patel, SB
   Reams, GP
   Spear, RM
   Freeman, RH
   Villarreal, D
AF Patel, Sanjeev B.
   Reams, Garry P.
   Spear, Robert M.
   Freeman, Ronald H.
   Villarreal, Daniel
TI Leptin: Linking obesity, the metabolic syndrome, and cardiovascular
   disease
SO CURRENT HYPERTENSION REPORTS
LA English
DT Article
ID RAT VENTRICULAR MYOCYTES; NITRIC-OXIDE; BLOOD-PRESSURE;
   ESSENTIAL-HYPERTENSION; CARDIAC-HYPERTROPHY; ENDOTHELIAL-CELLS;
   OXIDATIVE STRESS; LIPID OVERLOAD; PLASMA LEPTIN; SERUM-LEVELS
AB The incidence and prevalence of obesity and the metabolic syndrome have risen markedly in the past decade, representing a serious cardiovascular health hazard with significant morbidity and mortality. The etiology of the metabolic syndrome and its various pathogenic mechanisms are incompletely defined and under intense investigation. Contemporary research suggests that the adipocyte-derived hormone leptin may be an important factor linking obesity, the metabolic syndrome, and cardiovascular disorders. Although recent evidence indicates that under normal conditions leptin may be an important factor in regulating pressure and volume, during situations of chronic hyperleptinemia and leptin resistance, this hormone may function pathophysiologically for the development of hypertension and cardiac and renal diseases. Future research will determine if reduction of circulating leptin and/or blockade of its peripheral actions can confer cardiovascular and renal protection in hyperleptinemic patients with obesity and the metabolic syndrome.
C1 [Villarreal, Daniel] SUNY Upstate Med Univ, Div Cardiol, Dept Med, Syracuse, NY 13210 USA.
C3 State University of New York (SUNY) System; State University of New York
   (SUNY) Upstate Medical Center
RP Villarreal, D (corresponding author), SUNY Upstate Med Univ, Div Cardiol, Dept Med, Room 6142,750 E Adams St, Syracuse, NY 13210 USA.
EM Villarrd@upstate.edu
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NR 56
TC 117
Z9 134
U1 0
U2 11
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1522-6417
EI 1534-3111
J9 CURR HYPERTENS REP
JI Curr. Hypertens. Rep.
PD APR
PY 2008
VL 10
IS 2
BP 131
EP 137
DI 10.1007/s11906-008-0025-y
PG 7
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 307IO
UT WOS:000256312800009
PM 18474180
DA 2025-06-11
ER

PT J
AU Tesauro, M
   Schinzari, F
   Rovella, V
   Melina, D
   Mores, N
   Barini, A
   Mettimano, M
   Lauro, D
   Iantorno, M
   Quon, MJ
   Cardillo, C
AF Tesauro, Manfredi
   Schinzari, Francesca
   Rovella, Valentina
   Melina, Domenico
   Mores, Nadia
   Barini, Angela
   Mettimano, Marco
   Lauro, Davide
   Iantorno, Micaela
   Quon, Michael J.
   Cardillo, Carmine
TI Tumor necrosis factor-α antagonism improves vasodilation during
   hyperinsulinemia in metabolic syndrome
SO DIABETES CARE
LA English
DT Article
ID VASCULAR SMOOTH-MUSCLE; INSULIN-RESISTANCE; TNF-ALPHA; EXPRESSION; CELLS
AB OBJECTIVE - Obesity is associated with chronic inflammation due to overproduction of proinflammatory cytokines, including tumor necrosis factor (TNF)-alpha. We assessed the effects of TNF-alpha neutralization by infliximab on vascular reactivity during hyperinsulinemia in obesity-related metabolic syndrome.
   RESEARCH DESIGN AND METHODS - Vascular responses to intra-arterial infusion of acetylcholine (ACh) and sodium nitroprusside (SNP) were assessed in patients with metabolic syndrome, before and after administration of infliximab.
   RESULTS - Patients had blunted vasodilator responses to ACh and SNP during hyperinsulinemia compared with control subjects; a potentiation of the responsiveness to both ACh and SNP, however, was observed in patients following infliximab. The antioxidant vitamin C improved the vasodilator response to ACh in patients with metabolic syndrome, but its effect was not further enhanced by concurrent administration of infliximab.
   CONCLUSIONS - TNF-a neutralization ameliorates vascular reactivity in metabolic syndrome during hyperinsulinemia, likely in relation to decreased oxidative stress, thereby suggesting an involvement of inflammatory cytokines in vascular dysfunction of these patients.
C1 [Tesauro, Manfredi; Rovella, Valentina; Lauro, Davide] Univ Roma Tor Vergata, Rome, Italy.
   [Schinzari, Francesca; Melina, Domenico; Mores, Nadia; Barini, Angela; Mettimano, Marco; Cardillo, Carmine] Univ Cattolica Sacro Cuore, Rome, Italy.
   [Iantorno, Micaela; Quon, Michael J.] Natl Ctr Complementary & Alternat Med, NIH, Bethesda, MD USA.
C3 University of Rome Tor Vergata; Catholic University of the Sacred Heart;
   IRCCS Policlinico Gemelli; National Institutes of Health (NIH) - USA;
   NIH National Center for Complementary & Alternative Medicine (NCCAM)
RP Cardillo, C (corresponding author), Univ Roma Tor Vergata, Rome, Italy.
EM carmine.cardillo@rm.unicatt.it
RI Rovella, Valentina/AAB-9727-2019; schinzari, francesca/AAB-9982-2019;
   Quon, Michael/B-1970-2008
OI QUON, MICHAEL/0000-0002-5289-3707; Lauro, Davide/0000-0002-8597-4415;
   Quon, Michael/0000-0002-9601-9915; Rovella,
   Valentina/0000-0002-3311-486X; Cardillo, Carmine/0000-0001-5182-3005;
   MORES, Nadia/0000-0002-4197-0914
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NR 10
TC 43
Z9 46
U1 1
U2 2
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0149-5992
J9 DIABETES CARE
JI Diabetes Care
PD JUL
PY 2008
VL 31
IS 7
BP 1439
EP 1441
DI 10.2337/dc08-0219
PG 3
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 323CG
UT WOS:000257421000033
PM 18390795
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Yates, KF
   Larr, AS
   Sweat, V
   Maayan, L
   Siegel, C
   Convit, A
AF Yates, Kathy F.
   Larr, Allison S.
   Sweat, Victoria
   Maayan, Lawrence
   Siegel, Carole
   Convit, Antonio
TI Hispanic Youth With Excess Weight Display Psychological Distress: Do the
   Youth Self-Report Norms Accurately Capture This Phenomenon?
SO HISPANIC JOURNAL OF BEHAVIORAL SCIENCES
LA English
DT Article
DE minorities; excess weight; youth; psychological distress; Youth
   Self-Report Questionnaire
ID BODY-MASS INDEX; C-REACTIVE PROTEIN; ANXIETY DISORDERS; ADOLESCENT
   DEPRESSION; INSULIN-RESISTANCE; METABOLIC SYNDROME; OBESITY;
   ASSOCIATION; RISK; SYMPTOMS
AB Adolescent overweight/obesity (OW/O) has reached epidemic proportions. The Youth Self-Report (YSR) was administered to 514 primarily Hispanic urban high school students to examine the relationship between weight and psychological distress. YSR and study population-specific norms were used to assess risk on Anxious/Depressed, Withdrawn/Depressed, Somatic Complaints, and Social Problems scales. OW/O status increased Social Problems regardless of norms. OW/O students endorsed greater Withdrawn/Depressed symptoms with YSR norms; greater Anxious/Depressed and Somatic Complaints were endorsed with population-specific norms. Females drive results. Findings suggest norms need to incorporate minority and economically disadvantaged groups.
C1 [Yates, Kathy F.; Maayan, Lawrence; Convit, Antonio] NYU, Sch Med, New York, NY 10016 USA.
   [Sweat, Victoria] NYU, Sch Med, Brain Obes & Diabet Lab, New York, NY 10016 USA.
   [Sweat, Victoria] NYU, Sch Med, Banishing Obes & Diabet Youth Project, New York, NY 10016 USA.
   [Yates, Kathy F.; Larr, Allison S.; Maayan, Lawrence; Convit, Antonio] Nathan S Kline Inst Psychiat Res, Orangeburg, NY 10962 USA.
   [Siegel, Carole] Nathan S Kline Inst Psychiat Res, Stat & Serv Res Div, Orangeburg, NY 10962 USA.
   [Convit, Antonio] Nathan S Kline Inst Psychiat Res, Brain Obes & Diabet Lab, Orangeburg, NY 10962 USA.
   [Convit, Antonio] Nathan S Kline Inst Psychiat Res, Banishing Obes & Diabet Youth Project, Orangeburg, NY 10962 USA.
C3 New York University; New York University; New York University; Nathan
   Kline Institute for Psychiatric Research; Nathan Kline Institute for
   Psychiatric Research; Nathan Kline Institute for Psychiatric Research;
   Nathan Kline Institute for Psychiatric Research
RP Convit, A (corresponding author), NYU, Sch Med, Dept Psychiat, 145 East 32nd St,8th Floor, New York, NY 10016 USA.
EM antonio.convit@nyumc.org
OI Convit, Antonio/0000-0003-2201-2689; Maayan,
   Lawrence/0000-0003-3696-4760; Yates, Kathy/0000-0002-1844-8431; Siegel,
   Carole/0000-0002-7460-788X
FU Nathan Kline Institute for Psychiatric Research; NKI Center of
   Excellence in Culturally Competent Mental Health; NYU Langone Medical
   Center Community Service Plan
FX The authors disclosed receipt of the following financial support for the
   research, authorship, and/or publication of this article: This study was
   supported by the Nathan Kline Institute for Psychiatric Research and the
   NKI Center of Excellence in Culturally Competent Mental Health as well
   as the NYU Langone Medical Center Community Service Plan.
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NR 37
TC 1
Z9 3
U1 0
U2 10
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0739-9863
EI 1552-6364
J9 HISPANIC J BEHAV SCI
JI Hisp. J. Behav. Sci.
PD MAY
PY 2014
VL 36
IS 2
BP 195
EP 210
DI 10.1177/0739986314522111
PG 16
WC Psychology, Multidisciplinary
WE Social Science Citation Index (SSCI)
SC Psychology
GA AQ6LZ
UT WOS:000342925300006
DA 2025-06-11
ER

PT J
AU Marrazzo, G
   Barbagallo, I
   Galvano, F
   Malaguarnera, M
   Gazzolo, D
   Frigiola, A
   D'Orazio, N
   Volti, GL
AF Marrazzo, Giuseppina
   Barbagallo, Ignazio
   Galvano, Fabio
   Malaguarnera, Michele
   Gazzolo, Diego
   Frigiola, Alessandro
   D'Orazio, Nicolantonio
   Volti, Giovanni Li
TI Role of Dietary and Endogenous Antioxidants in Diabetes
SO CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
LA English
DT Review
DE Antioxidants; Diabetes; central nervous system; diet
ID NITRIC-OXIDE SYNTHASE; FACTOR-KAPPA-B; BLOOD-BRAIN-BARRIER; ALPHA-LIPOIC
   ACID; INSULIN-RESISTANCE SYNDROME; PANCREATIC BETA-CELLS; KINASE-C
   ACTIVATION; OXIDATIVE STRESS; SUPEROXIDE-PRODUCTION; LIPID-PEROXIDATION
AB Diabetes affects different people of all ages, race, and sex. This is a condition characterized by a state of chronic hyperglycaemia that leads to an increase of intracellular oxidative stress linked to the overproduction of free radicals. In the present review, we focus our attention on the molecular mechanisms leading to oxidative stress-mediates complications with particular regard to central nervous system (CNS). Furthermore, the present review reports the effects of different kind of antioxidants with enzymatic and nonenzymatic action that may significantly decrease the intracellular free radicals' overproduction and prevents the hyperglycaemia-mediated complications.
C1 [Marrazzo, Giuseppina; Barbagallo, Ignazio; Galvano, Fabio; Malaguarnera, Michele; Volti, Giovanni Li] Univ Catania, Dept Drug Sci, Biochem Sect, I-95100 Catania, Italy.
   [Gazzolo, Diego] Children Hosp, Neonatal Intens Care Unit, Cesare Arrigo, Alessandria, Italy.
   [Gazzolo, Diego; Frigiola, Alessandro; Volti, Giovanni Li] IRCCS Policlin S Donato, Dept Cardiac Surg, San Donato Milanese, MI, Italy.
   [D'Orazio, Nicolantonio] Univ G DAnnunzio, Dept Biochem Sci, Chieti, Italy.
C3 University of Catania; IRCCS Policlinico San Donato; G d'Annunzio
   University of Chieti-Pescara
RP Marrazzo, G (corresponding author), Univ Catania, Dept Drug Sci, Viale A Doria 6, I-95100 Catania, Italy.
EM g_marrazzo@alice.it
RI Frigiola, Alessandro/ABG-7502-2020; Volti, Giovanni/A-2435-2008;
   Malaguarnera, Michele/A-1376-2019; Galvano, Fabio/JSL-7451-2023;
   Galvano, Fabio/F-8122-2010
OI Li Volti, Giovanni/0000-0002-8678-2183; Galvano,
   Fabio/0000-0003-0644-0755; Frigiola, Alessandro/0000-0003-2762-9258;
   Barbagallo, Ignazio/0000-0002-7761-0662
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NR 180
TC 45
Z9 50
U1 1
U2 20
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1040-8398
EI 1549-7852
J9 CRIT REV FOOD SCI
JI Crit. Rev. Food Sci. Nutr.
PY 2014
VL 54
IS 12
BP 1599
EP 1616
DI 10.1080/10408398.2011.644874
PG 18
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA AI8QI
UT WOS:000337185700007
PM 24580561
DA 2025-06-11
ER

PT J
AU Ikejima, K
   Kon, K
   Yamashina, S
AF Ikejima, Kenichi
   Kon, Kazuyoshi
   Yamashina, Shunhei
TI Nonalcoholic fatty liver disease and alcohol-related liver disease: From
   clinical aspects to pathophysiological insights
SO CLINICAL AND MOLECULAR HEPATOLOGY
LA English
DT Article; Proceedings Paper
CT 14th International Symposium on Alcoholic Liver and Pancreatic Diseases
   and Cirrhosis (ISALPDC) held in conjunction with Liver Week
CY AUG 13-14, 2020
CL Korean Assoc Study Liver, Seoul, SOUTH KOREA
SP Korean Assoc HBP Surg, Korean Liver Canc Assoc, Korean Liver Transplantat Soc
HO Korean Assoc Study Liver
DE Alcohol; related liver disease; Non-alcoholic fatty liver disease;
   Stress responses; Immunity; Innate; Gut microbiota
ID METABOLIC SYNDROME; INTESTINAL MICROBIOME; GENDER-DIFFERENCES; CENTRAL
   ADIPOSITY; I148M VARIANT; RISK; PREVALENCE; PNPLA3; CANCER; ESOPHAGEAL
AB Two major causes of steatohepatitis are alcohol and metabolic syndrome. Although the underlying causes of alcoholrelated liver disease (ALD) and nonalcoholic fatty liver disease (NAFLD)/nonalcoholic steatohepatitis (NASH) differ, there are certain similarities in terms of the mode of disease progression and underlying pathophysiological mechanisms. Further, excessive alcohol consumption is often seen in patients with metabolic syndrome, and alcoholic hepatitis exacerbation by comorbidity with metabolic syndrome is an emerging clinical problem. There are certain ethnic differences in the development of both NAFLD and ALD. Especially, Asian populations tend to be more susceptible to NAFLD, and genetic polymorphisms in patatin-like phospholipase domain-containing 3 (PNPLA3) play a key role in both NAFLD and ALD. From the viewpoint of pathophysiology, cellular stress responses, including autophagy and endoplasmic reticulum (ER) stress, are involved in the development of cellular injury in steatohepatitis. Further, gutderived bacterial products and innate immune responses in the liver most likely play a profound role in the pathogenesis of both ALD and NASH. Though the recent progress in the treatment of viral hepatitis has reduced the prevalence of viral- related development of hepatocellular carcinoma (HCC), non-viral HCC is increasing. Alcohol and metabolic syndrome synergistically exacerbate progression of steatohepatitis, resulting in carcinogenesis. The gut-liver axis is a potential therapeutic and prophylactic target for steatohepatitis and subsequent carcinogenesis.
C1 [Ikejima, Kenichi; Kon, Kazuyoshi; Yamashina, Shunhei] Juntendo Univ, Grad Sch Med, Dept Gastroenterol, Tokyo, Japan.
C3 Juntendo University
RP Ikejima, K (corresponding author), Juntendo Univ, Grad Sch Med, Dept Gastroenterol, Bunkyo Ku, 2-1-1 Hongo, Tokyo 1138421, Japan.
EM ikejima@juntendo.ac.jp
RI Kon, Kazuyoshi/AAV-7832-2020
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NR 67
TC 29
Z9 28
U1 0
U2 11
PU KOREAN ASSOC STUDY LIVER
PI SEOUL
PA RM A1210, 53 MAPO-DAERO, MAPOTRAPALACE, DOWHA-DONG, MAPO-GU, SEOUL,
   04158, SOUTH KOREA
SN 2287-2728
EI 2287-285X
J9 CLIN MOL HEPATOL
JI Clin. Mol. Hepatol.
PD OCT
PY 2020
VL 26
IS 4
BP 728
EP 735
DI 10.3350/cmh.2020.0202
PG 8
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Gastroenterology & Hepatology
GA OE4OA
UT WOS:000580510600038
PM 33053942
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Chiang, CY
   Lo, SC
   Beckstead, JW
   Yang, CY
AF Chiang, Che-Yu
   Lo, Su-Chen
   Beckstead, Jason W.
   Yang, Chiu-Yueh
TI Associations between constipation risk and lifestyle, medication use,
   and affective symptoms in patients with schizophrenia: a multicenter
   cross-sectional study
SO SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY
LA English
DT Article
DE Anxiety symptoms; Constipation; Depressive symptoms; Predictors;
   Schizophrenia
ID PHYSICAL-ACTIVITY; METABOLIC SYNDROME; PREVALENCE; ANXIETY
AB PurposeTo investigate the association between lifestyle and atypical antipsychotic drug use in patients with schizophrenia and the risk of constipation and to assess the impact of anxiety and depressive symptoms on constipation risk.MethodsCross-sectional convenience sampling was employed, and 271 participants aged 20-65 were enrolled. Data were collected via a structured questionnaire comprising participants' demographic data, medication information, dietary behavior assessment, and the Baecke Physical Activity Questionnaire, Beck Depression Inventory-II, and Beck Anxiety Inventory. IBM SPSS 24.0 with multivariate logistic regression was used for data analysis. We performed a subgroup analysis of anticholinergic drugs via multivariate logistic regression.ResultsIn total, 180 participants had functional constipation; risk factors included female sex, anxiety symptoms, depressive symptoms, and quetiapine and aripiprazole use. Patients who drank more than 3,000 cc of water daily or used risperidone were less likely to have functional constipation. Depressive and anxiety symptoms were risk factors even after adjusting for sex, use of anticholinergics and laxatives, consuming two servings of fruit, consuming three servings of vegetables, consuming more than 3,000 cc of water daily, physical activity, medical comorbidity, chlorpromazine equivalent dose, and atypical antipsychotic use. Similar associations were found for two affective symptoms and functional constipation in the subgroup analysis of anticholinergic drugs.ConclusionThe prevalence of functional constipation in patients with schizophrenia was 66.4%. The risk factors included female sex, anticholinergics, aripiprazole, quetiapine, and depressive and anxiety symptoms. Risperidone users and those who drank 3000 cc of water daily were less likely to have constipation.
C1 [Chiang, Che-Yu] Cathay Gen Hosp, Dept Family & Community Med, Taipei, Taiwan.
   [Lo, Su-Chen; Yang, Chiu-Yueh] Natl Yang Ming Chiao Tung Univ, Taipei, Taiwan.
   [Beckstead, Jason W.] Univ S Florida, Coll Publ Hlth, Tampa, FL USA.
C3 Cathay General Hospital; National Yang Ming Chiao Tung University; State
   University System of Florida; University of South Florida
RP Yang, CY (corresponding author), Natl Yang Ming Chiao Tung Univ, Taipei, Taiwan.
EM scwowd@gmail.com; wanglsj@gmail.com; jbeckste@health.usf.edu;
   cyyang530904@nycu.edu.tw
RI Lo, Su Chen/KIE-8099-2024; Yang, Chiu-Yueh/AEK-3524-2022
OI Yang, Chiu-Yueh/0000-0002-5907-5619
FU National Yang Ming Chiao Tung University
FX Open Access funding enabled and organized by National Yang Ming Chiao
   Tung University.
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NR 50
TC 5
Z9 5
U1 1
U2 6
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0933-7954
EI 1433-9285
J9 SOC PSYCH PSYCH EPID
JI Soc. Psychiatry Psychiatr. Epidemiol.
PD FEB
PY 2025
VL 60
IS 2
BP 427
EP 440
DI 10.1007/s00127-024-02729-8
EA JUL 2024
PG 14
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA X5R7T
UT WOS:001272740700001
PM 39033249
OA hybrid
DA 2025-06-11
ER

PT J
AU Pohjantähti-Maaroos, H
   Palomäki, A
   Kankkunen, P
   Laitinen, R
   Husgafvel, S
   Oksanen, K
AF Pohjantahti-Maaroos, Hanna
   Palomaki, Ari
   Kankkunen, Paivi
   Laitinen, Ruth
   Husgafvel, Sari
   Oksanen, Kalevi
TI Circulating oxidized low-density lipoproteins and arterial elasticity:
   comparison between men with metabolic syndrome and physically active
   counterparts
SO CARDIOVASCULAR DIABETOLOGY
LA English
DT Article
ID CORONARY-HEART-DISEASE; PULSE-WAVE VELOCITY; CARDIOVASCULAR-DISEASE;
   OXIDATIVE STRESS; HYPERTENSIVE PATIENTS; VASCULAR COMPLIANCE;
   HEALTHY-MEN; RISK; LDL; STIFFNESS
AB Background: Accumulation of oxidized low-density lipoproteins in the intimae of arteries and endothelial dysfunction are key events in the development of atherosclerosis. Patients with metabolic syndrome are at high risk for cardiovascular diseases but the linkage between metabolic syndrome and atherosclerosis is incompletely understood. We studied whether the levels of oxidized LDL and arterial elasticity differ between metabolic syndrome patients and physically active controls.
   Methods: 40 men with metabolic syndrome and 40 physically active controls participated in this cross-sectional study. None of the study subjects had been diagnosed with cardiovascular disease. Levels of oxidized LDL were assessed by a two-site ELISA immunoassay. Arterial elasticity was assessed non-invasively by the HDI/PulseWave (TM) CR-2000 arterial tonometer.
   Results: Levels of oxidized LDL were 89.6 +/- 33.1 U/L for metabolic syndrome subjects and 68.5 +/- 23.6 U/ L for controls (p = 0.007). The difference remained significant after adjustment for LDL cholesterol. Large artery elasticity index (C1) was 16.2 +/- 4.1 mL/mmHgx10 for metabolic syndrome subjects and 19.4 +/- 3.7 mL/mmHgx10 for controls (p = 0.001), small artery indices (C2) were 7.0 +/- 3.2 mL/mmHgx100 and 6.5 +/- 2.9 mL/mmHgx100 (NS), respectively.
   Conclusions: Subjects with metabolic syndrome had elevated levels of oxidized LDL and reduced large arterial elasticity compared to controls. This finding may partly explain the increased risk for cardiovascular diseases among metabolic syndrome patients.
C1 [Pohjantahti-Maaroos, Hanna; Palomaki, Ari; Kankkunen, Paivi; Husgafvel, Sari; Oksanen, Kalevi] Kanta Hame Cent Hosp, FI-13530 Hameenlinna, Finland.
   [Pohjantahti-Maaroos, Hanna; Palomaki, Ari; Laitinen, Ruth] Linnan Klin, FI-13100 Hameenlinna, Finland.
   [Pohjantahti-Maaroos, Hanna] Kuopio Univ Hosp, FI-70211 Kuopio, Finland.
C3 University of Eastern Finland; University of Eastern Finland Hospital;
   Kuopio University Hospital
RP Pohjantähti-Maaroos, H (corresponding author), Kanta Hame Cent Hosp, Ahvenistontie 20, FI-13530 Hameenlinna, Finland.
EM hanna.pohjantahti-maaroos@kuh.fi
OI Palomaki, Ari/0000-0001-9759-4332
FU Ministry of Social Affairs and Health in Finland through Kanta-Hame
   Central Hospital; Finnish Cultural Foundation; Hilkka and Vaino Kiltti
   Foundation
FX This study was supported by grants from the Ministry of Social Affairs
   and Health in Finland through the Medical Research Fund of Kanta-Hame
   Central Hospital, the Hame Regional Fund under the auspices of the
   Finnish Cultural Foundation, and Hilkka and Vaino Kiltti Foundation. We
   appreciate the professional technical aid of Jaana Heikkinen, Kirsti
   Inkila and Paula Lahtinen. The authors gratefully acknowledge the
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NR 50
TC 23
Z9 23
U1 0
U2 1
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1475-2840
J9 CARDIOVASC DIABETOL
JI Cardiovasc. Diabetol.
PD AUG 20
PY 2010
VL 9
AR 41
DI 10.1186/1475-2840-9-41
PG 7
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism
GA 655RQ
UT WOS:000282267600002
PM 20727144
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Ullah, H
   Dacrema, M
   Buccato, DG
   Fayed, MAA
   De Lellis, LF
   Morone, MV
   Di Minno, A
   Baldi, A
   Daglia, M
AF Ullah, Hammad
   Dacrema, Marco
   Buccato, Daniele Giuseppe
   Fayed, Marwa A. A.
   De Lellis, Lorenza Francesca
   Morone, Maria Vittoria
   Di Minno, Alessandro
   Baldi, Alessandra
   Daglia, Maria
TI A Narrative Review on Plant Extracts for Metabolic Syndrome: Efficacy,
   Safety, and Technological Advances
SO NUTRIENTS
LA English
DT Review
DE plant extracts; functional foods; metabolic syndrome; efficacy; safety;
   technological advancements
ID VIRGIN OLIVE OIL; DIABETES-MELLITUS; INSULIN-RESISTANCE; CHRONIC
   COMPLICATIONS; ASSISTED EXTRACTION; MEDITERRANEAN DIET; OXIDATIVE
   STRESS; FENUGREEK SEEDS; LEAF EXTRACT; SUPPLEMENTATION
AB Metabolic syndrome, a global health concern, is characterized by visceral obesity, hyperglycemia, dyslipidemia, hypertension, and chronic low-grade inflammation. Current therapeutic options are limited by their varying efficacy and significantly adverse side effects, fueling interest in natural products, particularly plant extracts, as potential preventive interventions for high-risk individuals. This review examines the role of plant extracts in mitigating metabolic syndrome risk factors, addressing safety concerns and exploring associated technological advancements. The literature indicates that plant extracts hold promise for addressing the pathophysiology of metabolic dysfunction. However, challenges such as safety concerns, a lack of standardized regulation, and potential drug-plant interactions currently limit their clinical application. Rigorous, long-term clinical trials are necessary to confirm the efficacy and safety of plant extracts before they can be established as a preventive strategy for managing metabolic syndrome.
C1 [Ullah, Hammad; Dacrema, Marco; Buccato, Daniele Giuseppe; De Lellis, Lorenza Francesca; Di Minno, Alessandro; Baldi, Alessandra; Daglia, Maria] Univ Napoli Federico II, Dept Pharm, Via D Montesano 49, I-80131 Naples, Italy.
   [Ullah, Hammad] Xian Int Univ, Sch Med, Xian 710077, Peoples R China.
   [Fayed, Marwa A. A.] Univ Sadat City, Fac Pharm, Dept Pharmacognosy, Sadat 32897, Egypt.
   [Morone, Maria Vittoria] Univ Campania L Vanvitelli, Dept Expt Med, Sect Microbiol & Clin Microbiol, I-80138 Naples, Italy.
   [Di Minno, Alessandro] CEINGE Biotecnol Avanzate, Via Gaetano Salvatore 486, I-80145 Naples, Italy.
   [Daglia, Maria] Jiangsu Univ, Int Res Ctr Food Nutr & Safety, Zhenjiang 212013, Peoples R China.
C3 University of Naples Federico II; Egyptian Knowledge Bank (EKB);
   University of Sadat City; Universita della Campania Vanvitelli; CEINGE
   Biotecnologie Avanzate; Jiangsu University
RP Ullah, H; Daglia, M (corresponding author), Univ Napoli Federico II, Dept Pharm, Via D Montesano 49, I-80131 Naples, Italy.; Ullah, H (corresponding author), Xian Int Univ, Sch Med, Xian 710077, Peoples R China.; Daglia, M (corresponding author), Jiangsu Univ, Int Res Ctr Food Nutr & Safety, Zhenjiang 212013, Peoples R China.
EM hammad.ullah@unina.it; marcodacrema1991@gmail.com; d.buccato@gmail.com;
   marwa.fayed@fop.usc.edu.eg; lo.delellis2@gmail.com;
   mariavittoria.morone@unicampania.it; alessandro.diminno@unina.it;
   alessandra.baldi.alimenti@gmail.com; maria.daglia@unina.it
RI Ullah, Hammad/AAF-1802-2019; Morone, Maria Vittoria/LOR-6766-2024;
   Daglia, Maria/AAC-9498-2019; Fayed, Marwa/G-3960-2017; Dacrema,
   Marco/ABC-1304-2020; Di Minno, Alessandro/K-1948-2016
OI Di Minno, Alessandro/0000-0001-8084-9976; Daglia,
   Maria/0000-0002-4870-7713; Fayed, Marwa/0000-0001-5609-7436; Ullah,
   Hammad/0000-0001-9437-676X
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NR 163
TC 0
Z9 0
U1 2
U2 2
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD MAR
PY 2025
VL 17
IS 5
AR 877
DI 10.3390/nu17050877
PG 25
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 0AA1F
UT WOS:001442415200001
PM 40077747
OA gold
DA 2025-06-11
ER

PT J
AU Atas, H
   Gönül, M
AF Atas, Hatice
   Gonul, Muzeyyen
TI Increased Risk of Metabolic Syndrome in Patients with Vitiligo
SO BALKAN MEDICAL JOURNAL
LA English
DT Article
DE Metabolic syndrome; vitiligo; screening
ID OXIDATIVE STRESS; PATHOGENESIS
AB Background: Inflammatory and immune processes can be triggered in vitiligo due to a decreased number of melanocytes and their anti-inflammatory effects. Because of the systemic nature of vitiligo, metabolic abnormalities such as insulin resistance and lipid profile disturbances as well as skin involvement may be observed in vitiligo.
   Aims: To investigate the association between metabolic syndrome and vitiligo.
   Study Design: Case-control study.
   Methods: The demographic, clinical and laboratory features in the subjects were compared according to presence of vitiligo and metabolic syndrome [ patients (n=63) vs. gender-age matched controls (n=65) and metabolic syndrome positive (n=38) vs. negative (n=90)]. A logistic regression analysis was also used.
   Results: We identified metabolic syndrome in 24 (38.1%) subjects with vitiligo and 14 (21.5%) subjects without vitiligo (p=0.04). Active vitiligo, segmental vitiligo, an increased duration of vitiligo and an increased percentage in the affected body surface area were determined to be independent predictors of metabolic syndrome [activity of vitiligo: p=0.012, OR (95% CI)=64.4 (2.5-1672); type of vitiligo: p=0.007, OR (95% CI)=215.1 (4.3-10725.8); duration of vitiligo: p=0.03, OR (95% CI)=1.4 (1.1-2.0); percentage of affected body surface area: p=0.07, OR (95% CI)=1.2(0.98-1.5)].
   Conclusion: The risk of developing metabolic syndrome is increased in patients with vitiligo. The poor clinical features of vitiligo, such as active, extended and segmental vitiligo with an increased duration of time, are independent predictors for developing metabolic syndrome.
C1 [Atas, Hatice; Gonul, Muzeyyen] Univ Hlth Sci, Diskapi Yildirim Beyazit Training & Res Hosp, Dept Dermatol, Ankara, Turkey.
C3 University of Health Sciences Turkey; Diskapi Yildirim Beyazit Training
   & Research Hospital
RP Atas, H (corresponding author), Univ Hlth Sci, Diskapi Yildirim Beyazit Training & Res Hosp, Dept Dermatol, Ankara, Turkey.
EM drhaticeartik@gmail.com
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NR 28
TC 38
Z9 40
U1 0
U2 2
PU GALENOS PUBL HOUSE
PI ISTANBUL
PA  MOLLA GURANI MAHALLESI KACAMAK SOKAK NO 21-1, ISTANBUL, TURKEY
SN 2146-3123
EI 2146-3131
J9 BALK MED J
JI Balk. Med. J.
PD MAY
PY 2017
VL 34
IS 3
BP 219
EP 225
DI 10.4274/balkanmedj.2016.1005
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA FD6BT
UT WOS:000407614500006
PM 28443562
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Tomiyama, AJ
AF Tomiyama, A. Janet
TI Weight stigma is stressful. A review of evidence for the Cyclic
   Obesity/Weight-Based Stigma model
SO APPETITE
LA English
DT Review
DE Obesity; Overweight; Stigma; Cortisol; Stress; Eating behavior
ID SOCIAL IDENTITY; MENTAL-HEALTH; BODY-IMAGE; CORTISOL RESPONSES;
   METABOLIC SYNDROME; EATING-DISORDER; SIZE ACCEPTANCE; TEASING HISTORY;
   UNITED-STATES; PUBLIC-HEALTH
AB Weight stigma is highly pervasive, but its consequences are understudied. This review draws from theory in social psychology, health psychology, and neuroendocrinology to construct an original, generative model called the cyclic obesity/weight-based stigma (COBWEBS) model. This model characterizes weight stigma as a "vicious cycle" - a positive feedback loop wherein weight stigma begets weight gain. This happens through increased eating behavior and increased cortisol secretion governed by behavioral, emotional, and physiological mechanisms, which are theorized to ultimately result in weight gain and difficulty of weight loss. The purpose of this review is to evaluate the existing literature for evidence supporting such a model, propose ways in which individuals enter, fight against, and exit the cycle, and conclude by outlining fruitful future directions in this nascent yet important area of research. (C) 2014 Elsevier Ltd. All rights reserved.
C1 Univ Calif Los Angeles, Dept Psychol, Los Angeles, CA 90095 USA.
C3 University of California System; University of California Los Angeles
RP Tomiyama, AJ (corresponding author), Univ Calif Los Angeles, Dept Psychol, 1235 Franz Hall, Los Angeles, CA 90095 USA.
EM tomiyama@psych.ucla.edu
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NR 104
TC 460
Z9 575
U1 10
U2 128
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 0195-6663
EI 1095-8304
J9 APPETITE
JI Appetite
PD NOV 1
PY 2014
VL 82
BP 8
EP 15
DI 10.1016/j.appet.2014.06.108
PG 8
WC Behavioral Sciences; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Behavioral Sciences; Nutrition & Dietetics
GA AR2AK
UT WOS:000343385500003
PM 24997407
OA Green Published
DA 2025-06-11
ER

PT J
AU Silverstein-Metzler, MG
   Shively, CA
   Clarkson, TB
   Appt, SE
   Carr, JJ
   Kritchevsky, SB
   Jones, SR
   Register, TC
AF Silverstein-Metzler, Marnie G.
   Shively, Carol A.
   Clarkson, Thomas B.
   Appt, Susan E.
   Carr, J. Jeffrey
   Kritchevsky, Stephen B.
   Jones, Sara R.
   Register, Thomas C.
TI Sertraline inhibits increases in body fat and carbohydrate dysregulation
   in adult female cynomolgus monkeys
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE Selective serotonin reuptake inhibitors (SSRIs); Metabolic syndrome;
   Diabetes mellitus; Depression; Nonhuman primate; Macaque
ID METABOLIC SYNDROME; SOCIAL STRESS; DEPRESSION; BEHAVIOR; GLUCOSE;
   ADIPONECTIN; COMORBIDITY; PAROXETINE; RECEPTORS; BIOMARKER
AB Selective serotonin reuptake inhibitor (SSRI) antidepressants are widely prescribed for depression and other disorders. SSRIs have become one of the most commonly used drugs in the United States, particularly by women. Acute effects on body composition and carbohydrate metabolism have been reported, but little is known regarding the effects of chronic SSRI use. We evaluated the effects of chronic administration of a commonly prescribed SSRI, sertraline HCI, on body weight and composition, fat distribution, carbohydrate metabolism, as well as activity, in adult female depressed and nondepressed cynomolgus monkeys (Macaca fascicularis; n = 42) using a placebo-controlled, longitudinal, randomized study design. Phenotypes were evaluated prior to and after 18 months of oral sertraline (20 mg/kg) or placebo. Over the 18 month treatment period, the placebo group experienced increases in body weight, body fat (visceral and subcutaneous) fasting insulin concentrations, and homeostasis model assessment of insulin resistance scores (HOMA-IR). Sertraline treatment prevented increases in body weight, fat, insulin, and HOMA-IR (all p<0.05), without significantly altering activity levels. Sertraline treatment altered adiponectin in an unusual way - reducing circulating adiponectin in depressed monkeys without affecting fat mass or body weight. Deleterious effects on adiponectin, a potentially insulin-sensitizing and atheroprotective protein, may result in adverse effects on cardiovascular health despite otherwise beneficial effects on body composition and carbohydrate metabolism. (C) 2016 Published by Elsevier Ltd.
C1 [Silverstein-Metzler, Marnie G.; Shively, Carol A.; Clarkson, Thomas B.; Appt, Susan E.; Register, Thomas C.] Wake Forest Sch Med, Dept Pathol Comparat Med, Winston Salem, NC USA.
   [Silverstein-Metzler, Marnie G.] Wake Forest Sch Med, Integrated Physiol & Pharmacol Grad Program, Winston Salem, NC USA.
   [Carr, J. Jeffrey] Vanderbilt Univ, Dept Radiol & Radiol Sci, Sch Med, Nashville, TN 37235 USA.
   [Kritchevsky, Stephen B.] Wake Forest Sch Med, Internal Med Gerontol & Geriatr Med, Winston Salem, NC USA.
   [Jones, Sara R.] Wake Forest Sch Med, Dept Physiol & Pharmacol, Winston Salem, NC USA.
C3 Wake Forest University; Wake Forest University; Vanderbilt University;
   Wake Forest University; Wake Forest University
RP Register, TC (corresponding author), Dept Pathol Comparat Med, Med Ctr Blvd, Winston Salem, NC 27157 USA.
EM register@wakehealth.edu
RI Kritchevsky, Stephen/JWP-7971-2024; Register, Thomas/KLY-9188-2024;
   Shively, Carol/L-2921-2019; Jones, Sara/K-4816-2014; Carr,
   John/A-1938-2012
OI Jones, Sara/0000-0002-3424-7576; Register, Thomas/0000-0002-4078-0166;
   Carr, John/0000-0002-4398-8237
FU NIH [ROIHL87103, R21MH86731, T32OD10957]; Pepper Older Americans for
   Independence Center [P30 AG21332]
FX This work was supported in part by NIH grants ROIHL87103, R21MH86731,
   T32OD10957, and the Pepper Older Americans for Independence Center (P30
   AG21332). The contents are solely the responsibility of the authors and
   do not necessarily represent the view of the NIH.
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NR 53
TC 17
Z9 18
U1 0
U2 14
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
EI 1873-3360
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD JUN
PY 2016
VL 68
BP 29
EP 38
DI 10.1016/j.psyneuen.2016.02.012
PG 10
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA DM3AF
UT WOS:000376218500005
PM 26939086
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Wang, GL
   Zhong, DY
   Liu, HH
   Yang, T
   Liang, QQ
   Wang, J
   Zhang, RG
   Zhang, YL
AF Wang, Guoliang
   Zhong, Diying
   Liu, Haohan
   Yang, Tao
   Liang, Qiqi
   Wang, Jing
   Zhang, Runguang
   Zhang, Youlin
TI Water soluble dietary fiber from walnut meal as a prebiotic in
   preventing metabolic syndrome
SO JOURNAL OF FUNCTIONAL FOODS
LA English
DT Article
DE Walnut meal; Dietary fiber; Metabolic syndrome; Gut microbiota
AB Dietary fiber intake is associated with a low incidence of suffering from metabolic syndrome. To explore the potential health benefits of walnut meal dietary fiber (WMDF) as a prebiotic, the functional role of WMDF on metabolic syndrome in mice induced by high fructose diet (20%, HF) was investigated. The animal experiment results showed that administration of WMDF to HF-fed mice alleviated abnormal body weight gain, insulin resistance, oxidative stress, lipid metabolism disorders and inflammation. Histopathological observation confirmed the preventative effects of WMDF on hepatic steatosis and vascular endothelial dysfunction. Also, WMDF intake increased the production of acetic acid, propionic acid and butyric acid. Moreover, WMDF ingestion effectively improved the disorder of gut microbiota caused by HF, increased the diversity of gut microbiota and the relative abundance of short-chain fatty acids-producing bacteria. These findings demonstrate WMDF can be used as a prebiotic to prevent HF-induced metabolic syndrome.
C1 [Wang, Guoliang; Zhong, Diying; Liu, Haohan; Yang, Tao; Liang, Qiqi; Wang, Jing; Zhang, Runguang; Zhang, Youlin] Shaanxi Normal Univ, Coll Food Engn & Nutr Sci, Xian 710119, Peoples R China.
C3 Shaanxi Normal University
RP Zhang, YL (corresponding author), West Changan Ave, Xian 710119, Peoples R China.
EM youlinzh@snnu.edu.cn
RI yang, tao/HJP-6478-2023
OI Wang, Guoliang/0000-0002-9685-1840
FU Fundamental Research Funds for the Central Universities [2019TS084];
   Shaanxi Provincial Science and Technology Department
   [2018TSCXL-NY-06-02]; Agriculture Department of Shaanxi Province
   [NYKJ-2018-XA-06]; Shaanxi Province Science and Technology Department
   project [2019NY-133]
FX This work was supported by the Fundamental Research Funds for the
   Central Universities (2019TS084) , the Shaanxi Provincial Science and
   Technology Department (2018TSCXL-NY-06-02) , the Agriculture Department
   of Shaanxi Province (NYKJ-2018-XA-06) and the Shaanxi Province Science
   and Technology Department project (2019NY-133) .
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NR 64
TC 27
Z9 30
U1 4
U2 40
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1756-4646
EI 2214-9414
J9 J FUNCT FOODS
JI J. Funct. Food.
PD MAR
PY 2021
VL 78
AR 104358
DI 10.1016/j.jff.2021.104358
EA JAN 2021
PG 14
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA QQ3HD
UT WOS:000624414200005
OA gold
DA 2025-06-11
ER

PT J
AU Ntona, S
   Papaefthymiou, A
   Kountouras, J
   Gialamprinou, D
   Kotronis, G
   Boziki, M
   Polyzos, SA
   Tzitiridou, M
   Chatzopoulos, D
   Thavayogarajah, T
   Gkolia, I
   Ntonas, G
   Vardaka, E
   Doulberis, M
AF Ntona, Smaragda
   Papaefthymiou, Apostolis
   Kountouras, Jannis
   Gialamprinou, Dimitra
   Kotronis, Georgios
   Boziki, Marina
   Polyzos, Stergios A.
   Tzitiridou, Maria
   Chatzopoulos, Dimitrios
   Thavayogarajah, Tharshika
   Gkolia, Ioanna
   Ntonas, Georgios
   Vardaka, Elisabeth
   Doulberis, Michael
TI Impact of nonalcoholic fatty liver disease-related metabolic state on
   depression
SO NEUROCHEMISTRY INTERNATIONAL
LA English
DT Article
DE NAFLD; MAFLD; NASH; Nonalcoholic fatty liver disease; Metabolic
   syndrome; Depression; Gut dysbiosis
ID HELICOBACTER-PYLORI INFECTION; L-ASPARTATE LOLA; GUT-MICROBIOTA;
   INSULIN-RESISTANCE; BILE-ACIDS; NESFATIN-1 LEVEL; ANXIETY; RISK;
   ASSOCIATION; MOOD
AB Nonalcoholic fatty liver disease (NAFLD), also recently referred as metabolic (dysfunction)-associated fatty liver disease (MAFLD), is characterized by hepatocyte steatosis in the setting of metabolic risk conditions and in the absence of an underlying precursor, for instance alcohol consumption, hepatotropic viruses and hepatotoxic drugs. A possible association between NAFLD and depression has been proposed, owing to intersecting pathophysiological pathways. This narrative review aimed to summarize the current evidence that illustrate the potential pathophysiological and clinical linkage between NAFLD-related metabolic state and depression. Prefrontal cortex lesions are suggested to be a consequence of liver steatosis-associated systematic hyperinflammatory state, a phenomenon also occurring in depression. In addition, depressive symptoms are present in neurotransmitter imbalances. These abnormalities seem to be correlated with NAFLD/MAFLD, in terms of insulin resistance (IR), ammonia and gut dysbiosis' impact on serotonin, dopamine, noradrenaline levels and gamma aminobutyric acid receptors. Furthermore, reduced levels of nesfatin-1 and copine-6-associated BDNF (brainderived neurotrophic factor) levels have been considered as a probable link between NAFLD and depression. Regarding NAFLD-related gut dysbiosis, it stimulates mediators including lipopolysaccharides, short-chain fatty acids and bile acids, which play significant role in depression. Finally, western diet and IR, which are mainstay components of NAFLD/MAFLD, are, also, substantiated to affect neurotransmitters in hippocampus and produce neurotoxic lipids that contribute to neurologic dysfunction, and thus trigger emotional disturbances, mainly depressive symptoms.
C1 [Ntona, Smaragda] Med Univ Sofia, Alexandrovska Univ Hosp, Sofia 1431, Bulgaria.
   [Papaefthymiou, Apostolis] Univ Hosp Larisa, Dept Gastroenterol, Larisa 41110, Thessaly, Greece.
   [Papaefthymiou, Apostolis; Polyzos, Stergios A.] Aristotle Univ Thessaloniki, Lab Pharmacol 1, Thessaloniki 54124, Macedonia, Greece.
   [Papaefthymiou, Apostolis; Kountouras, Jannis; Gialamprinou, Dimitra; Kotronis, Georgios; Tzitiridou, Maria; Chatzopoulos, Dimitrios; Vardaka, Elisabeth; Doulberis, Michael] Aristotle Univ Thessaloniki, Ippokrat Hosp, Sch Med, Med Clin 2, Thessaloniki 54642, Macedonia, Greece.
   [Gialamprinou, Dimitra] Aristotle Univ Thessaloniki, Papageorgiou Gen Hosp, Neonatal Dept 2, Thessaloniki 56403, Macedonia, Greece.
   [Gialamprinou, Dimitra] Aristotle Univ Thessaloniki, Papageorgiou Gen Hosp, NICU, Thessaloniki 56403, Macedonia, Greece.
   [Kotronis, Georgios] Gen Hosp Aghios Pavlos Thessaloniki, Dept Internal Med, Thessaloniki 55134, Macedonia, Greece.
   [Boziki, Marina] Aristotle Univ Thessaloniki, AHEPA Univ Gen Hosp Thessaloniki, Neurol Dept 2, Thessaloniki 54636, Macedonia, Greece.
   [Tzitiridou, Maria] Univ West Macedonia, Sch Healthcare Sci, Midwifery Dept, Kozani 50100, Macedonia, Greece.
   [Thavayogarajah, Tharshika] Univ Hosp, Dept Med Oncol & Hematol, CH-8091 Zurich, Switzerland.
   [Thavayogarajah, Tharshika] Univ Zurich, CH-8091 Zurich, Switzerland.
   [Gkolia, Ioanna] Psychiat Hosp Thessaloniki, Stavroupoli 54634, Macedonia, Greece.
   [Ntonas, Georgios] Agios Dimitrios Gen Hosp, Dept Anesthesiol, Thessaloniki 54635, Macedonia, Greece.
   [Vardaka, Elisabeth] Int Hellenic Univ, Sch Hlth Sci, Dept Nutr Sci & Dietet, Thessaloniki 57400, Greece.
   [Doulberis, Michael] Univ Zurich, Dept Gastroenterol & Hepatol, CH-8091 Zurich, Switzerland.
   [Doulberis, Michael] Kantonsspital Aarau, Med Univ Dept, Div Gastroenterol & Hepatol, CH-5001 Aarau, Switzerland.
C3 Medical University Sofia; General University Hospital of Larissa;
   Aristotle University of Thessaloniki; Aristotle University of
   Thessaloniki; Papageorgiou Hospital; Aristotle University of
   Thessaloniki; Aristotle University of Thessaloniki; Papageorgiou
   Hospital; Aristotle University of Thessaloniki; University of Zurich;
   University Zurich Hospital; University of Zurich; International Hellenic
   University; University of Zurich; Kantonsspital Aarau AG (KSA)
RP Kountouras, J (corresponding author), 8 Fanariou St, Thessaloniki 55133, Macedonia, Greece.
EM jannis@auth.gr
RI Polyzos, Stergios/H-2844-2019; VARDAKA, Elisabeth/ABD-1341-2020; Boziki,
   Marina/ACF-8768-2022; Doulberis, Michael/Y-5118-2018; Papaefthymiou,
   Apostolis/HPH-4021-2023; Tzitiridou, Dr. Maria/KHW-8314-2024
OI Doulberis, Michael/0000-0002-0396-5081; Papaefthymiou,
   Apostolis/0000-0002-3563-4973; Tzitiridou, Dr.
   Maria/0000-0001-6051-0860; Thavayogarajah, Tharshika/0000-0003-3110-1384
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NR 158
TC 10
Z9 10
U1 5
U2 25
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0197-0186
EI 1872-9754
J9 NEUROCHEM INT
JI Neurochem. Int.
PD FEB
PY 2023
VL 163
AR 105484
DI 10.1016/j.neuint.2023.105484
EA JAN 2023
PG 12
WC Biochemistry & Molecular Biology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Neurosciences & Neurology
GA 8I5XV
UT WOS:000921807300001
PM 36634820
DA 2025-06-11
ER

PT J
AU Deng, YY
   Ngai, FW
   Qin, J
   Yang, L
   Wong, KP
   Wang, HH
   Xie, YJ
AF Deng, Yun-Yang
   Ngai, Fei-Wan
   Qin, Jing
   Yang, Lin
   Wong, Ka-Po
   Wang, Harry-Haoxiang
   Xie, Yao-Jie
TI Combined Influence of Eight Lifestyle Factors on Metabolic Syndrome
   Incidence: A Prospective Cohort Study from the MECH-HK Study
SO NUTRIENTS
LA English
DT Article
DE lifestyle; lifestyle score; lifestyle index; combined lifestyle;
   metabolic syndrome
ID ALCOHOL-CONSUMPTION; PHYSICAL-ACTIVITY; SLEEP DURATION; METAANALYSIS;
   RISK; ASSOCIATION; ADULTS; RELIABILITY; POPULATION; PREVALENCE
AB Although previous studies have shown significant associations between individual lifestyles and metabolic syndrome, limited studies have explored the combined effect of lifestyles. The purpose of this study was to investigate whether a combined lifestyle score was associated with metabolic syndrome incidence in Hong Kong Chinese women. This prospective cohort study included 1634 women (55.9 +/- 8.6 years) without baseline metabolic syndrome, diabetes, myocardial infarction, or stroke. Eight lifestyle factors (smoking, physical activity, sedentary time, sleep, stress, fatigue, diet, and alcohol) were included by assigning 0 (unhealthy) or 1 point (healthy). The overall score was the sum of these points, ranging from 0 (the least healthy) to 8 points (the healthiest). Metabolic syndrome was diagnosed by the joint interim statement. During a 1.16-year follow-up, 179 (11.0%) new metabolic syndrome cases were identified. The incidences for the 0-3-point, 4-point, 5-point, and 6-8-point groups were 12.8% (79/618), 11.5% (42/366), 9.4% (29/309), and 8.5% (29/341), respectively. Compared to the lowest combined lifestyle score group, the highest group had a 47% reduced metabolic syndrome incidence, with an adjusted odds ratio and 95% confidence interval of 0.53 (0.33-0.86) (p = 0.010). These findings indicate that a higher combined lifestyle score was associated with a lower metabolic syndrome incidence in this population.
C1 [Deng, Yun-Yang; Ngai, Fei-Wan; Qin, Jing; Yang, Lin; Xie, Yao-Jie] Hong Kong Polytech Univ, Sch Nursing, Hong Kong, Peoples R China.
   [Wong, Ka-Po] Hong Kong Polytech Univ, Dept Appl Social Sci, Hong Kong, Peoples R China.
   [Wang, Harry-Haoxiang] Sun Yat Sen Univ, Sch Publ Hlth, Guangzhou 510080, Peoples R China.
   [Wang, Harry-Haoxiang] Univ Edinburgh, Coll Med & Vet Med, Edinburgh EH8 9AG, Scotland.
   [Xie, Yao-Jie] Hong Kong Polytech Univ, Res Ctr Chinese Med Innovat, Hong Kong, Peoples R China.
C3 Hong Kong Polytechnic University; Hong Kong Polytechnic University; Sun
   Yat Sen University; University of Edinburgh; Hong Kong Polytechnic
   University
RP Xie, YJ (corresponding author), Hong Kong Polytech Univ, Sch Nursing, Hong Kong, Peoples R China.; Xie, YJ (corresponding author), Hong Kong Polytech Univ, Res Ctr Chinese Med Innovat, Hong Kong, Peoples R China.
EM yunyang.deng@polyu.edu.hk; vivian.ngai@polyu.edu.hk;
   harry.qin@polyu.edu.hk; l.yang@polyu.edu.hk; portia.wong@polyu.edu.hk;
   wanghx27@mail.sysu.edu.cn; grace.yj.xie@polyu.edu.hk
RI Deng, Yunyang/ABF-9759-2021; Wong, Ka/AAW-7752-2020; Ngai,
   Fei/E-9878-2010; Wang, Harry H.X./E-9027-2015; Xie, Yao Jie/K-7001-2014;
   Yang, Lin/F-9601-2014
OI Wang, Harry H.X./0000-0002-0361-6527; WONG, Ka Po/0000-0002-9086-3701;
   Xie, Yao Jie/0000-0001-9289-4985; Yang, Lin/0000-0002-5964-3233
FU Early Career Scheme, the Research Grants Council of the University
   Grants Committee: HK; Family Planning Association of Hong Kong; Hong
   Kong Federation of Women's Center (HKFWC); Huazhou Hometown Association
FX The authors would like to express their sincere gratitude to all women
   who participated in this study. They would like to extend their
   heartfelt gratitude to the Family Planning Association of Hong Kong
   (FPAHK), the Hong Kong Federation of Women's Center (HKFWC), the Huazhou
   Hometown Association (HHA), the Association of Hong Kong Nursing Staff
   (AHKNS), and the Integrative Health Clinic (IHC) of The Hong Kong
   Polytechnic University for their unwavering support and assistance
   throughout the study. Special appreciation is also expressed to the
   dedicated research assistants and student helpers for their valuable
   contributions to the study.
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NR 64
TC 3
Z9 3
U1 2
U2 7
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD FEB
PY 2024
VL 16
IS 4
AR 547
DI 10.3390/nu16040547
PG 17
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA JH2O7
UT WOS:001172210600001
PM 38398871
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Rangel-Zúñiga, OA
   Camargo, A
   Marin, C
   Peña-Orihuela, P
   Pérez-Martínez, P
   Delgado-Lista, J
   González-Guardia, L
   Yubero-Serrano, EM
   Tinahones, FJ
   Malagón, MM
   Pérez-Jiménez, F
   Roche, HM
   López-Miranda, J
AF Alberto Rangel-Zuniga, Oriol
   Camargo, Antonio
   Marin, Carmen
   Pena-Orihuela, Patricia
   Perez-Martinez, Pablo
   Delgado-Lista, Javier
   Gonzalez-Guardia, Lorena
   Yubero-Serrano, Elena M.
   Tinahones, Francisco J.
   Malagon, Maria M.
   Perez-Jimenez, Francisco
   Roche, Helen M.
   Lopez-Miranda, Jose
TI Proteome from patients with metabolic syndrome is regulated by quantity
   and quality of dietary lipids
SO BMC GENOMICS
LA English
DT Article
DE Metabolic syndrome; Proteomics; Inflammation; Oxidative stress; DNA
   damage
ID BLOOD MONONUCLEAR-CELLS; OXIDATIVE DNA-DAMAGE; KAPPA-B ACTIVATION;
   MEDITERRANEAN DIET; POSTPRANDIAL CHANGES; ARP2/3 COMPLEX; ACTIN;
   INFLAMMATION; STRESS; MODEL
AB Background: Metabolic syndrome is a multi-component disorder associated to a high risk of cardiovascular disease. Its etiology is the result of a complex interaction between genetic and environmental factors, including dietary habits. We aimed to identify the target proteins modulated by the long-term consumption of four diets differing in the quality and quantity of lipids in the whole proteome of peripheral blood mononuclear cells (PBMC).
   Results: A randomized, controlled trial conducted within the LIPGENE study assigned 24 MetS patients for 12 weeks each to 1 of 4 diets: a) high-saturated fatty acid (HSFA), b) high monounsaturated fatty acid (HMUFA), c) low-fat, high-complex carbohydrate diets supplemented with placebo (LFHCC) and d) low-fat, high-complex carbohydrate diets supplemented with long chain (LC) n-3 polyunsaturated fatty acids (PUFA) (LFHCC n-3). We analyzed the changes induced in the proteome of both nuclear and cytoplasmic fractions of PBMC using 2-D proteomic analysis. Sixty-seven proteins were differentially expressed after the long-term consumption of the four diets. The HSFA diet induced the expression of proteins responding to oxidative stress, degradation of ubiquitinated proteins and DNA repair. However, HMUFA, LFHCC and LFHCC n-3 diets down-regulated pro-inflammatory and oxidative stress-related proteins and DNA repairing proteins.
   Conclusion: The long-term consumption of HSFA, compared to HMUFA, LFHCC and LFHCC n-3, seems to increase the cardiovascular disease (CVD) risk factors associated with metabolic syndrome, such as inflammation and oxidative stress, and seem lead to DNA damage as a consequence of high oxidative stress.
C1 [Alberto Rangel-Zuniga, Oriol; Camargo, Antonio; Marin, Carmen; Pena-Orihuela, Patricia; Perez-Martinez, Pablo; Delgado-Lista, Javier; Gonzalez-Guardia, Lorena; Yubero-Serrano, Elena M.; Perez-Jimenez, Francisco; Lopez-Miranda, Jose] Univ Cordoba, IMIBIC Reina Sofia Univ Hosp, Lipids & Atherosclerosis Res Unit, E-14004 Cordoba, Spain.
   [Alberto Rangel-Zuniga, Oriol; Camargo, Antonio; Marin, Carmen; Pena-Orihuela, Patricia; Perez-Martinez, Pablo; Delgado-Lista, Javier; Gonzalez-Guardia, Lorena; Yubero-Serrano, Elena M.; Tinahones, Francisco J.; Malagon, Maria M.; Perez-Jimenez, Francisco; Lopez-Miranda, Jose] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr CIBEROBN, Madrid, Spain.
   [Tinahones, Francisco J.] Hosp Virgen de la Victoria, Endocrinol & Nutr Serv, Malaga, Spain.
   [Malagon, Maria M.] Univ Cordoba, IMIBIC Reina Sofia Univ Hosp, Dept Cell Biol Physiol & Immunol, E-14004 Cordoba, Spain.
   [Roche, Helen M.] Univ Coll Dublin, Sch Publ Hlth & Populat Sci, UCD Conway Inst, UCD Inst Food & Hlth, Dublin 2, Ireland.
C3 Universidad de Cordoba; Instituto de Salud Carlos III; CIBER - Centro de
   Investigacion Biomedica en Red; CIBEROBN; Universidad de Cordoba;
   University College Dublin
RP López-Miranda, J (corresponding author), Univ Cordoba, IMIBIC Reina Sofia Univ Hosp, Lipids & Atherosclerosis Res Unit, Av Menendez Pidal S-N, E-14004 Cordoba, Spain.
EM jlopezmir@gmail.com
RI Marin Hinojosa, Carmen/AFO-1294-2022; Yubero-Serrano, Elena/H-4832-2013;
   Delgado-Lista, Javier/KAM-7412-2024; Lopez-Miranda, Jose/Y-8306-2019;
   Roche, Helen/AAF-4164-2019; Tinahones, Francisco/AAB-2882-2020; Jimenez,
   Francisco/AAJ-9559-2021; Camargo Garcia, Antonio/G-9720-2015; Perez
   Martinez, Pablo/AEL-6176-2022; MALAGON, MARIA M/L-5386-2014
OI Camargo Garcia, Antonio/0000-0002-0415-4184; Pena Orihuela, Patricia
   J/0009-0009-9970-043X; Lopez-Miranda, Jose/0000-0002-8844-0718; Delgado
   Lista, Francisco Javier/0000-0002-2982-2716; Tinahones, Francisco
   J/0000-0001-6871-4403; Perez Martinez, Pablo/0000-0001-7716-8117;
   Rangel-Zuniga, Oriol Alberto/0000-0003-3495-5705; Yubero-Serrano, Elena
   M/0000-0002-2733-5359; MALAGON, MARIA M/0000-0002-2419-2727; Roche,
   Helen/0000-0002-0628-3318
FU European Union [LIPGENE European Integrated Project] [505944];
   Ministerio de Ciencia e Innovacion [AGL2004-07907, AGL2006-01979,
   AGL2009-12270]; CIBER Fisiopatologia de la Obesidad y Nutricion
   [CB06/03/0047]; Consejeria de Innovacion, Ciencia y Empresa, Junta de
   Andalucia [P06-CTS-01425, CTS-03039]; Consejeria de Salud, Junta de
   Andalucia [06/128, 07/43, PI-0193]; Fondo Europeo de Desarrollo Regional
   (FEDER)
FX This work was supported partly by research grants from the European
   Union [LIPGENE European Integrated Project-505944], from the Ministerio
   de Ciencia e Innovacion [grant numbers AGL2004-07907, AGL2006-01979,
   AGL2009-12270 (to J.L.-M.)]; CIBER Fisiopatologia de la Obesidad y
   Nutricion [grant number CB06/03/0047]; Consejeria de Innovacion, Ciencia
   y Empresa, Junta de Andalucia [grant number P06-CTS-01425 (to J.L.-M.)
   CTS-03039 (to MMM)]; and Consejeria de Salud, Junta de Andalucia [grant
   numbers 06/128, 07/43, PI-0193 (to J.L.-M.)]; and the Fondo Europeo de
   Desarrollo Regional (FEDER). The CIBEROBN is an initiative of the
   Instituto de Salud Carlos III, Madrid, Spain. We would like to thank Ma
   Jose Gomez-Luna for her technical support.
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NR 63
TC 22
Z9 23
U1 1
U2 13
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1471-2164
J9 BMC GENOMICS
JI BMC Genomics
PD JUL 8
PY 2015
VL 16
AR 509
DI 10.1186/s12864-015-1725-8
PG 12
WC Biotechnology & Applied Microbiology; Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Genetics & Heredity
GA CM3DI
UT WOS:000357561500001
PM 26152126
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Malik, MM
   Ganatra, N
   Siby, R
   Kumar, S
   Khan, S
   Jayaprakasan, SK
   Cheriachan, D
   Desai, HN
   Sangurima, L
AF Malik, Maujid Masood
   Ganatra, Nency
   Siby, Rosemary
   Kumar, Sanjay
   Khan, Sara
   Jayaprakasan, Srilakshmi K.
   Cheriachan, Doju
   Desai, Heet N.
   Sangurima, Leslie
TI The Cellular Genesis of Metabolic Syndrome and the Role of Anti-urate
   Drugs in Hyperuricemia Patients: A Systematic Review
SO CUREUS JOURNAL OF MEDICAL SCIENCE
LA English
DT Review
DE xanthine oxide; kidneys; xor inhibitors; inflammation; xanthine
   oxidoreductase (xor); oxidative stress; hyperuricemia; metabolic
   syndrome
ID URIC-ACID; ALLOPURINOL; ASSOCIATION; ADULTS
AB Hyperuricemia results due to the underexcretion of uric acid through kidneys or overproduction due to either intake of purine-rich foods, a high caloric diet, or a decreased activity of purine recycler hypoxanthine-guanine phosphoribosyl transferase (HGPRT). Increased xanthine oxidoreductase (XOR) enzyme activity may contribute to hyperuricemia. Literature provides growing evidence that an independent component that contributes to the development of metabolic syndrome (MetS) and associated comorbidities is hyperuricemia. Thus, precise cellular mechanisms involved during MetS and related comorbidities in hyperuricemia, and the role of anti-urate medicines in these mechanisms require further investigations. We searched online libraries PubMed and Google Scholar for data collection. We used Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 guidelines for literature identification, selection, screening, and determining eligibility to produce unbiased meaningful outcomes. We applied quality assessment tools for the quality appraisal of the studies. And, outcomes were extracted from the selected studies, which revealed the relationship between hyperuricemia and MetS components by causing inflammation, endothelial dysfunction, oxidative stress, and endoplasmic reticulum stress. The selected studies reflected the role of xanthine oxide (XO) inhibitors beyond inhibition. This systematic review concluded that hyperuricemia independently causes inflammation, oxidative stress, endothelial damage, and endoplasmic reticulum stress in patients with hyperuricemia. These mechanisms provide a cellular basis for metabolic syndrome and related comorbidities. In this context, XO inhibitors and their beneficial effects go beyond XOR inhibition to ameliorate these pathological mechanisms.
C1 [Malik, Maujid Masood] King Faisal Univ, Biomed Sci, Al Ahsa, Norway.
   [Ganatra, Nency; Siby, Rosemary; Khan, Sara; Desai, Heet N.; Sangurima, Leslie] Calif Inst Behav Neurosci & Psychol, Internal Med, Fairfield, CA USA.
   [Kumar, Sanjay] Bahria Univ, Pakistan Navy Ship PNS Shifa Hosp, Internal Med, Med & Dent Coll, Karachi, Pakistan.
   [Jayaprakasan, Srilakshmi K.] Dr Bhim Rao Ambedkar Med Coll & Hosp, Pediat, Bengaluru, India.
   [Cheriachan, Doju] Calif Inst Behav Neurosci & Psychol, Emergency Med, Fairfield, CA USA.
RP Malik, MM (corresponding author), King Faisal Univ, Biomed Sci, Al Ahsa, Norway.
EM drmaujid@hotmail.com
RI Malik, Maujid/HHC-9032-2022
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NR 47
TC 2
Z9 2
U1 1
U2 5
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
EI 2168-8184
J9 CUREUS J MED SCIENCE
JI Cureus J Med Sci
PD JUN 16
PY 2024
VL 16
IS 6
AR e62472
DI 10.7759/cureus.62472
PG 10
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA WP0Z7
UT WOS:001255974100023
PM 39015868
OA gold
DA 2025-06-11
ER

PT J
AU Sharma, S
   Taliyan, R
   Ramagiri, S
AF Sharma, Sorabh
   Taliyan, Rajeev
   Ramagiri, Shruti
TI Histone Deacetylase Inhibitor, Trichostatin A, Improves Learning and
   Memory in High-Fat Diet-Induced Cognitive Deficits in Mice
SO JOURNAL OF MOLECULAR NEUROSCIENCE
LA English
DT Article
DE Alzheimer's disease; Cognitive deficit; Diabetes mellitus; Histone
   deacetylases; Oxidative stress
ID OXIDATIVE STRESS; INSULIN-RESISTANCE; OBESITY; ACETYLCHOLINESTERASE;
   AMELIORATION; SUPPRESSION; IMPAIRMENT; DEMENTIA; INCREASE; MODEL
AB Metabolic syndrome is increasingly recognized for its effects on cognitive health. Recent studies have highlighted the role of histone deacetylases (HDACs) in metabolic syndrome and cognitive functions. The present study was designed to investigate the possible therapeutic role of a HDAC inhibitor, trichostatin A (TSA), in cognitive impairment associated with metabolic syndrome. To ascertain the mechanisms involved, we fed mice with high-fat diet (HFD) for 4 weeks and examined changes in behavioral and biochemical/oxidative stress markers. Mice subjected to HFD exhibited characteristic features of metabolic disorder, viz., hyperglycemia, hypertriglyceridemia, hypercholesterolemia, and lower high-density lipoprotein (HDL) cholesterol levels. Moreover, these mice showed severe deficits in learning and memory as assessed by the Morris water maze and passive avoidance tasks along with elevated oxidative stress and inflammatory markers in brain homogenates. The observed changes occurred concurrently with reduced brain-derived neurotrophic factor (BDNF). In contrast, the mice treated with the HDAC inhibitor, TSA (0.5 and 1 mg/kg, i.p.), showed a significant and dose-dependent reduction in serum glucose, triglycerides, and total cholesterol along with improvement in HDL-cholesterol levels and learning and memory performance. TSA treatment also results in alleviation of oxidative stress and neuroinflammatory markers. Moreover, TSA significantly augmented the BDNF levels in HFD-fed mice. Thus, based upon these observations, it may be suggested that HDAC inhibition could be a novel therapeutic strategy to combat cognitive impairment associated with metabolic syndrome.
C1 [Sharma, Sorabh; Taliyan, Rajeev; Ramagiri, Shruti] Birla Inst Technol & Sci, Dept Pharm, Pilani 333031, Rajasthan, India.
C3 Birla Institute of Technology & Science Pilani (BITS Pilani)
RP Taliyan, R (corresponding author), Birla Inst Technol & Sci, Dept Pharm, Pilani 333031, Rajasthan, India.
EM taliyanraja@gmail.com
RI Taliyan, Rajeev/I-4069-2019
FU UGC, New Delhi, India; BITS, Pilani, India
FX Authors are thankful to UGC, New Delhi, India and BITS, Pilani, India
   for their financial support for this study.
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NR 45
TC 53
Z9 56
U1 1
U2 19
PU HUMANA PRESS INC
PI TOTOWA
PA 999 RIVERVIEW DRIVE SUITE 208, TOTOWA, NJ 07512 USA
SN 0895-8696
EI 1559-1166
J9 J MOL NEUROSCI
JI J. Mol. Neurosci.
PD MAY
PY 2015
VL 56
IS 1
BP 1
EP 11
DI 10.1007/s12031-014-0461-x
PG 11
WC Biochemistry & Molecular Biology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Neurosciences & Neurology
GA CF0VW
UT WOS:000352263400001
PM 25391764
DA 2025-06-11
ER

PT J
AU Ben Othman, R
   Berriche, O
   Gamoudi, A
   Mizouri, R
   Jerab, D
   Ben Amor, N
   Mahjoub, F
   Jamoussi, H
AF Ben Othman, Rym
   Berriche, Olfa
   Gamoudi, Amel
   Mizouri, Ramla
   Jerab, Donia
   Ben Amor, Nadia
   Mahjoub, Faten
   Jamoussi, Henda
TI Cross sectional study about nutritional risk factors of metabolically
   unhealthy obesity
SO ROMANIAN JOURNAL OF INTERNAL MEDICINE
LA English
DT Article
DE Obesity; Mediterranean diet; Metabolic syndrome; sleep disorder; olive
   oil
ID SWEETENED BEVERAGE CONSUMPTION; MEDITERRANEAN DIET; VEGETABLE
   CONSUMPTION; ANTIOXIDANT CAPACITY; METAANALYSIS; STRESS; FRUIT;
   INFLAMMATION; VALIDATION; ADHERENCE
AB Introduction: a substantial proportion of obese subjects are metabolically healthy and free from metabolic complications. Many mechanisms that could explain the existence of the metabolically healthy obese phenotype have been suggested, involving in particular the a healthy lifestyle and diet. The aim of this study was to study the anthropometric, nutritional and biological profile of two groups: obese with metabolic syndrome (MS+) and obese without metabolic syndrome (MS-). Methods: It is a cross-sectional study, conducted between January 2022 and 15 march 2022. We recruited 90 obese MS+ and 82 obese MS - . Both groups were matched for age and sex. The glycemia, triglycerides (TG), total cholesterol (TC), HDL-C, LDL-C were measured as well as the body composition and anthropometric data. The diet was determined by the 24-hour recalls. Eating disorders, sleep disorders (PSS4 scale) and depression (HADS) were also searched. Results: In MS+ group we noticed: higher BMI, waist circumference, more caloric diet, elevated consumption of saccharides. This group had more eating disorders such as night eating syndrome and bulimia and sleeping disorders (sleep onset and total insomnia). MS + group was more stressed and depressed. As for MS - group had a Mediterranean diet and had more intake of: EPA, DHA, olive oil, green tea, oleaginous fruits, linseed, vegetables and Whole grains. They also practiced more fasting. Conclusions: it is important to know the protective nutritional factors of the metabolic syndrome in order to be able to focus on them during education sessions and thus protect the obese from metabolic complications.
C1 [Ben Othman, Rym; Mizouri, Ramla] Univ Tunis El Manar, Fac Med Tunis, 11 Rue Jbal Lakhdhar, Bab Saadoun Tunis 1029, Tunisia.
   [Berriche, Olfa; Gamoudi, Amel; Jerab, Donia; Ben Amor, Nadia; Mahjoub, Faten; Jamoussi, Henda] Natl Inst Nutr & Food Technol Serv, Tunis, Tunisia.
C3 Universite de Tunis-El-Manar; Faculte de Medecine de Tunis (FMT)
RP Ben Othman, R (corresponding author), Univ Tunis El Manar, Fac Med Tunis, 11 Rue Jbal Lakhdhar, Bab Saadoun Tunis 1029, Tunisia.
EM benothmanr@gmail.com
RI Mahjoub, Faten/HKV-9508-2023; ben othman, rym/KBB-9864-2024; pons,
   bernard/A-6688-2017; jammoussi, henda/AAH-9354-2021
OI Berriche, Olfa/0009-0009-1952-8415; jamoussi, henda/0000-0002-8215-3718;
   ben othman, rym/0000-0002-2453-9778; Mahjoub, Faten/0000-0001-6217-4987
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Z9 3
U1 1
U2 6
PU SCIENDO
PI WARSAW
PA BOGUMILA ZUGA 32A, WARSAW, MAZOVIA, POLAND
SN 1582-3296
EI 2501-062X
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PD MAR 1
PY 2023
VL 61
IS 1
BP 53
EP 62
DI 10.2478/rjim-2022-0023
EA DEC 2022
PG 10
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA A1AL5
UT WOS:000895350700001
PM 36476238
OA gold
DA 2025-06-11
ER

PT J
AU Oh, J
   Kim, E
   Huh, I
AF Oh, Jinkyung
   Kim, Eunmi
   Huh, Iksoo
TI Associations between weekend catch-up sleep and health-related quality
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SO SCIENTIFIC REPORTS
LA English
DT Article
ID METABOLIC SYNDROME; SEX-DIFFERENCES; OLDER-ADULTS; DURATION; RISK;
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AB This study investigated associations between weekend catch-up sleep (WCUS) and health-related quality of life (HRQoL) in 15,837 participants from the 7th (2016-2018) Korea National Health and Nutrition Examination Survey. We categorized WCUS durations into four groups: none (<= 0 h [h]), short (> 0 h, <= 1 h), medium (> 1 h, <= 2 h), and long (> 2 h), and performed complex samples logistic regression and likelihood ratio chi(2) test. The study found significant associations in women for the European Quality of Life-5 Dimensions (EQ-5D) index and three EQ-5D subdomains (self-care, usual activities, and anxiety/depression) with the WCUS durations, but no significant association in men. Compared to the non-WCUS, the short or medium WCUS was positively associated with the EQ-5D index and EQ- 5D subdomains (usual activities and anxiety/depression) in women, while the long WCUS significantly reduced the quality of life in the self-care domain. In an additional subgroup analysis by age, middle-aged and elderly women had a more noticeable effect of WCUS on HRQoL than young women, and the short or medium WCUS improved HRQoL in middle-aged and elderly women in general. Therefore, we recommend appropriate WCUS durations to improve HRQoL, considering both gender and age.
C1 [Oh, Jinkyung; Kim, Eunmi; Huh, Iksoo] Seoul Natl Univ, Coll Nursing, Seoul 03080, South Korea.
   [Huh, Iksoo] Seoul Natl Univ, Res Inst Nursing Sci, Seoul 03080, South Korea.
C3 Seoul National University (SNU); Seoul National University (SNU)
RP Huh, I (corresponding author), Seoul Natl Univ, Coll Nursing, Seoul 03080, South Korea.; Huh, I (corresponding author), Seoul Natl Univ, Res Inst Nursing Sci, Seoul 03080, South Korea.
EM huhixoo1@snu.ac.kr
OI Oh, Jinkyung/0000-0002-2111-6569
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NR 68
TC 7
Z9 7
U1 1
U2 13
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD NOV 20
PY 2023
VL 13
IS 1
AR 20280
DI 10.1038/s41598-023-47244-z
PG 12
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA MI2L1
UT WOS:001192927200123
PM 37985799
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Osali, A
AF Osali, Ali
TI Aerobic exercise and nano-curcumin supplementation improve inflammation
   in elderly females with metabolic syndrome
SO DIABETOLOGY & METABOLIC SYNDROME
LA English
DT Article
DE Aerobic exercise; Inflammation; Oxidative stress; Metabolic syndrome;
   Nano-curcumin
ID C-REACTIVE PROTEIN; OXIDATIVE STRESS; WEIGHT-LOSS; OBESITY; ANTIOXIDANT;
   MECHANISMS; TARGETS; ADULTS
AB Background Aging, inflammation, oxidative stress, and metabolic syndrome are the main important factors in brain-derived neurotrophic factor (BDNF) level. Aim The aim of this research was to investigate the effect of 6-week aerobic exercise with moderate intensity and consumption of nano-curcumin on IL-6, IL-10 and BDNF in 60-65 year females with metabolic syndrome (MS). Materials and methods Forty-four women with metabolic syndrome (Mets) voluntarily took part in the present study. Participants were randomly divided into 4 groups of MetS exercise + Nano-Curcumin (MENC), MetS exercise (ME), MetS Nano-Curcumin (MNC), MetS control (MC). During the first week, MENC and ME groups participated in three sets of 10-min aerobic exercise training (AT) with a treadmill with 5-min rest parts between the sets. One minute was added to the duration of exercise sets weekly. Blood samples were collected before and after 6 weeks. IL-6, IL-10 and BDNF levels were measured by ELISA method. To analyze the data, Paired-samples t-test with the significance level of (P <= 0.05). Results IL-10 and BDNF concentrations significantly increased after a 6-week intervention (P <= 0.05). Also, IL-6 serum levels significantly decreased (P <= 0.05). Besides, the results of the present study suggested that nano-curcumin supplementation significantly decreases serum concentrations of malondialdehyde (MDA), and hs-CRP in subjects with metabolic syndrome. In addition, the results of the present study suggested that nano-curcumin supplementation significantly increases serum concentrations of BDNF, IL-10, and total antioxidant capacity (TAC) in subjects with metabolic syndrome. Conclusion Findings show that both of the regular exercise and consumption of NanoCurcumin for 6 weeks reduce inflammation. Combination of these two leads to even more reduction of inflammation. The regular exercise led to a decrease at the fat percentage, which deceased IL-6 level and increased IL-10 level. So, this change led to increasing BDNF's levels. Trial registration IRCT2017082335857N1 Registered 2017-11-16, https://en.irct.ir/trial/26971
C1 [Osali, Ali] Univ Bonab, Dept Gen Courses, Bonab, Iran.
C3 University of Bonab
RP Osali, A (corresponding author), Univ Bonab, Dept Gen Courses, Bonab, Iran.
EM osaliphd@bonabu.ac.ir
FU University of Bonab, Iran [97/I/ER/1920]
FX This article is taken from research project number 97/I/ER/1920,
   sponsored by University of Bonab, Iran.
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NR 29
TC 49
Z9 51
U1 1
U2 14
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1758-5996
J9 DIABETOL METAB SYNDR
JI Diabetol. Metab. Syndr.
PD MAR 30
PY 2020
VL 12
IS 1
AR 26
DI 10.1186/s13098-020-00532-4
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA KZ0HL
UT WOS:000522953200002
PM 32256716
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Eisenmann, JC
AF Eisenmann, JC
TI Secular trends in variables associated with the metabolic syndrome of
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SO AMERICAN JOURNAL OF HUMAN BIOLOGY
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DT Article
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AB The aim of this article is to summarize and critique reports from selected largescale population health surveys (U.S. and Canada national health surveys (e.g., National Health and Nutrition Examination Survey, Youth Risk Behavior Survey, and Canada Fitness Survey), and active research programs in preventive pediatric cardiology (i.e., Bogalusa Heart Study, Princeton Lipids Study, and Minneapolis Blood Pressure Study)) pertaining to the secular trend in variables associated with the metabolic syndrome of North American youth. These surveys were chosen since they have published peer-reviewed articles on the topic and consist of relatively large samples. The increased body mass index and prevalence of overweight and obesity are clear, particularly over the past two decades. The secular increase in overweight and obesity cannot be linked to available self-report data on physical activity or diet, although measurement issues need to be considered. The emergence of Type II diabetes in adolescents parallels the increase in obesity; however, subsequent changes in blood lipids and blood pressure are less clear. There is some evidence to suggest adverse changes in the blood lipid profile. Aerobic fitness, as determined by maximal oxygen consumption (VO2max), has not appeared to change in youth except perhaps for adolescent females. The results suggesting the emergence of metabolic syndrome X during childhood and adolescence are discussed in the context of perturbation and dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis. It can be suggested that a subsistent lifestyle consisting of increased lifestyle activity (not exercise per se), a prudent diet, adequate sleep and rest, and stress reduction be advocated to combat diseases of Western Civilization/metabolic syndrome that have affected North American children (and adults) in recent years. The results also highlight the importance of population surveillance of obesity, physical activity, and dietary intake and cardiovascular health of children into the 21st century. (C) 2003 Wiley-Liss, Inc.
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RP Iowa State Univ, Dept Hlth & Human Performance, 255 Forker Bldg, Ames, IA 50010 USA.
EM jce@istate.edu
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NR 54
TC 90
Z9 114
U1 0
U2 11
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1042-0533
EI 1520-6300
J9 AM J HUM BIOL
JI Am. J. Hum. Biol.
PD NOV-DEC
PY 2003
VL 15
IS 6
BP 786
EP 794
DI 10.1002/ajhb.10214
PG 9
WC Anthropology; Biology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Anthropology; Life Sciences & Biomedicine - Other Topics
GA 738RY
UT WOS:000186302700007
PM 14595870
DA 2025-06-11
ER

PT J
AU Gargiulo, P
   Marsico, F
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   Perrone-Filardi, P
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AF Gargiulo, Paola
   Marsico, Fabio
   Renga, Francesco
   Dell'Aversana, Simona
   Esposito, Immacolata
   Marciano, Caterina
   Dellegrottaglie, Santo
   Perrone-Filardi, Pasquale
   Paolillo, Stefania
TI The metabolic syndrome in heart failure: insights to specific mechanisms
SO HEART FAILURE REVIEWS
LA English
DT Article
DE Heart failure; Metabolic syndrome; Diabetic cardiomyopathy; Insulin
   resistance
ID DIABETIC CARDIOMYOPATHY; INSULIN-RESISTANCE; OXIDATIVE STRESS;
   ENDOTHELIAL DYSFUNCTION; VENTRICULAR DYSFUNCTION; EMPAGLIFLOZIN;
   MITOCHONDRIA; INFLAMMATION; PREVALENCE; ACTIVATION
AB The presence of comorbidities significantly influences long-term morbidity and mortality of symptomatic and asymptomatic heart failure (HF) patients. Metabolic syndrome and diabetic cardiomyopathy are two clinical conditions that share multiple pathophysiological mechanisms and that might be both responsible for cardiac dysfunction. However, it is argued whether metabolic syndrome (MS) independently increases HF risk or the association between MS and HF merely reflects the impact of individual risk factors included in its definition on HF development. Similarly, in the context of diabetic cardiomyopathy, many aspects are still challenging starting from the definition up to the therapeutic management. In this clinical review, we focused the attention on molecular pathways, myocyte alterations, and specific patterns of metabolic syndrome and diabetic cardiomyopathy in order to better define the potential diagnostic and therapeutic approaches of these two pathological conditions.
C1 [Gargiulo, Paola; Perrone-Filardi, Pasquale] IRCCS SDN, Naples, Italy.
   [Marsico, Fabio; Renga, Francesco; Dell'Aversana, Simona; Esposito, Immacolata; Perrone-Filardi, Pasquale; Paolillo, Stefania] Federico II Univ Naples, Dept Adv Biomed Sci, Sect Cardiol, Via Pansini 5, I-80131 Naples, Italy.
   [Marciano, Caterina] Ist Diagnost Varelli, Naples, Italy.
   [Dellegrottaglie, Santo] Osped Accreditato Villa Fiori, Div Cardiol, Acerra, Naples, Italy.
   [Paolillo, Stefania] Mediterranea Cardiocentro, Naples, Italy.
C3 IRCCS Istituto di Ricerca Diagnostica e Nucleare (SDN); University of
   Naples Federico II
RP Perrone-Filardi, P (corresponding author), IRCCS SDN, Naples, Italy.
EM fpperron@unina.it
RI Gargiulo, Paola/K-6885-2016; Perrone Filardi, Pasquale/AAC-7590-2022
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NR 55
TC 33
Z9 34
U1 1
U2 12
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1382-4147
EI 1573-7322
J9 HEART FAIL REV
JI Heart Fail. Rev.
PD JAN
PY 2020
VL 25
IS 1
SI SI
BP 1
EP 7
DI 10.1007/s10741-019-09838-6
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA KJ4FZ
UT WOS:000512015000001
PM 31414215
DA 2025-06-11
ER

PT J
AU Batacan, RB
   Duncan, MJ
   Dalbo, VJ
   Buitrago, GL
   Fenning, AS
AF Batacan, Romeo B., Jr.
   Duncan, Mitch J.
   Dalbo, Vincent J.
   Buitrago, Geraldine L.
   Fenning, Andrew S.
TI Effect of different intensities of physical activity on cardiometabolic
   markers and vascular and cardiac function in adult rats fed with a
   high-fat high-carbohydrate diet
SO JOURNAL OF SPORT AND HEALTH SCIENCE
LA English
DT Article
DE High-intensity interval training; Inflammation; Light-intensity
   training; Metabolic syndrome; Oxidative stress; Sedentary behavior;
   Western diet
ID SYMPATHETIC-NERVOUS-SYSTEM; CONTINUOUS MODERATE EXERCISE; LIFE-STYLE
   INTERVENTION; HIGH-FRUCTOSE DIET; METABOLIC SYNDROME; OXIDATIVE STRESS;
   LIGHT-INTENSITY; BLOOD-PRESSURE; ENDOTHELIAL DYSFUNCTION; INSULIN
   SENSITIVITY
AB Background: Physical activity (PA) and diet are 2 lifestyle factors that affect cardiometabolic risk. However, data on how a high-fat high-carbohydrate (HFHC) diet influences the effect of different intensities of PA on cardiometabolic health and cardiovascular function in a controlled setting are yet to be fully established. This study investigated the effect of sedentary behavior, light-intensity training (LIT), and high-intensity interval training (HIIT) on cardiometabolic markers and vascular and cardiac function in HFHC-fed adult rats.
   Methods: Twelve-week-old Wistar rats were randomly allocated to 4 groups (12 rats/group): control (CTL), sedentary (SED), LIT, and HIIT. Biometric indices, glucose and lipid control, inflammatory and oxidative stress markers, vascular reactivity, and cardiac electrophysiology of the experimental groups were examined after 12 weeks of HFHC-diet feeding and PA interventions.
   Results: The SED group had slower cardiac conduction (p = 0.0426) and greater thoracic aortic contractile responses (p < 0.05) compared with the CTL group. The LIT group showed improved cardiac conduction compared with the SED group (p = 0.0003), and the HIIT group showed decreased mesenteric artery contractile responses compared with all other groups and improved endothelium-dependent mesenteric artery relaxation compared with the LIT group (both p < 0.05). The LIT and HIIT groups had lower visceral (p = 0.0057 for LIT, p = 0.0120 for HIIT) and epididymal fat (p < 0.0001 for LIT, p = 0.0002 for HIIT) compared with the CTL group.
   Conclusion: LIT induced positive adaptations on fat accumulation and cardiac conduction, and HIIT induced a positive effect on fat accumulation, mesenteric artery contraction, and endothelium-dependent relaxation. No other differences were observed between groups. These findings suggest that few positive health effects can be achieved through LIT and HIIT when consuming a chronic and sustained HFHC diet. (C) 2018 Production and hosting by Elsevier B.V. on behalf of Shanghai University of Sport.
C1 [Batacan, Romeo B., Jr.; Dalbo, Vincent J.; Fenning, Andrew S.] Cent Queensland Univ, Sch Med & Appl Sci, Rockhampton, Qld 4702, Australia.
   [Batacan, Romeo B., Jr.] Cent Queensland Univ, Ctr Phys Activ Studies, Rockhampton, Qld 4702, Australia.
   [Duncan, Mitch J.] Univ Newcastle, Fac Hlth & Med, Prior Res Ctr Phys Activ & Nutr, Sch Med & Publ Hlth, Callaghan, NSW 2308, Australia.
   [Dalbo, Vincent J.] Cent Queensland Univ, Clin Biochem Lab, Rockhampton, Qld 4702, Australia.
   [Buitrago, Geraldine L.] James Cook Univ, Australian Inst Trop Hlth & Med, Ctr Biodiscovery & Mol Dev Therapeut, Cairns, Qld 4870, Australia.
C3 Central Queensland University; Central Queensland University; University
   of Newcastle; Central Queensland University; James Cook University
RP Batacan, RB (corresponding author), Cent Queensland Univ, Sch Med & Appl Sci, Rockhampton, Qld 4702, Australia.
EM r.j.batacan@cqu.edu.au
RI Duncan, Mitch/V-1708-2019
OI BUITRAGO, GERALDINE/0000-0003-1389-5301; Duncan,
   Mitch/0000-0002-9166-6195; BATACAN, ROMEO JR/0000-0002-6084-7452
FU Strategic Research Scholarship grant from Central Queensland University
   (CQU); CQU Health CRN; Future Leader Fellowship from the National Heart
   Foundation of Australia [100029]
FX The authors would like to thank Kylie Connolly, Candice Pullen, and
   Douglas Jackson for their assistance during the terminal experiments and
   Dr. Jeff Coombes for allowing RBB to work in his laboratory for the
   F2-isoprostane analysis. RBB is supported by the Strategic Research
   Scholarship grant from Central Queensland University (CQU). This
   manuscript is in part supported by CQU Health CRN. MJD is supported by a
   Future Leader Fellowship (ID 100029) from the National Heart Foundation
   of Australia.
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NR 116
TC 22
Z9 23
U1 0
U2 19
PU SHANGHAI UNIV SPORT
PI SHANGHAI
PA EDITORIAL BOARD, 650 QINGYUANHUAN RD, SHANGHAI, 200438, PEOPLES R CHINA
SN 2095-2546
EI 2213-2961
J9 J SPORT HEALTH SCI
JI J. Sport Health Sci.
PD JAN
PY 2018
VL 7
IS 1
BP 109
EP 119
DI 10.1016/j.jshs.2016.08.001
PG 11
WC Hospitality, Leisure, Sport & Tourism; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Social Sciences - Other Topics; Sport Sciences
GA FX2XL
UT WOS:000425929600016
PM 30356452
OA Green Published, gold, Green Accepted
DA 2025-06-11
ER

PT J
AU Park, DY
   Ahn, YT
   Huh, CS
   McGregor, RA
   Choi, MS
AF Park, Do-Young
   Ahn, Young-Tae
   Huh, Chul-Sung
   McGregor, Robin A.
   Choi, Myung-Sook
TI Dual probiotic strains suppress high fructose-induced metabolic syndrome
SO WORLD JOURNAL OF GASTROENTEROLOGY
LA English
DT Article
DE Dyslipidemia; Fasting glucose; Gut microbiota; High-fructose diet;
   Inflammation; Insulin resistance; Lactobacillus; Metabolic syndrome;
   Oxidative stress; Probiotic
ID GUT MICROBIOTA; INSULIN SENSITIVITY; LINOLEIC-ACID; DIET; OBESITY;
   GLUCOSE; SUPPLEMENTATION; BEVERAGES; YOGURT; PLASMA
AB AIM: To investigate the effect of novel probiotics on the clinical characteristics of high-fructose induced metabolic syndrome.
   METHODS: Male Wistar rats aged 4 wk were fed a 70% w/w high-fructose diet (n = 27) or chow diet (n = 9) for 3 wk to induce metabolic syndrome, the rats were then randomized into groups and administered probiotic [Lactobacillus curvatus (L. curvatus) HY7601 and Lactobacillus plantarum (L. plantarum) KY1032] at 10(9) cfu/d or 10(10) cfu/d or placebo by oral gavage for 3 wk. Food intake and body weight were measured once a week. After 6 wk, the rats were fasted for 12 h, then anesthetized with diethyl ether and sacrificed. Blood samples were taken from the inferior vena cava for plasma analysis of glucose, insulin, C-peptide, total-cholesterol, triglycerides and thiobarbituric acid-reacting substances. Real-time polymerase chain reaction was performed using mouse-specific Taqman probe sets to assess genes related to fatty acid beta-oxidation, lipogenesis and cholesterol metabolism in the liver. Target gene expression was normalized to the housekeeping gene, glyceraldehyde-3-phosphate dehydrogenase.
   RESULTS: Rodents fed a high-fructose diet developed clinical characteristics of the metabolic syndrome including increased plasma glucose, insulin, triglycerides, total cholesterol and oxidative stress levels, as well as increased liver mass and liver lipids compared to chow fed controls. Probiotic treatment (L. curvatus HY7601 and L. plantarum KY1032) at high (10(10) cfu/d) or low dosage (10(9) cfu/d) lowered plasma glucose, insulin, triglycerides and oxidative stress levels. Only high-dose probiotic treatment reduced liver mass and liver cholesterol. Probiotic treatment reduced lipogenesis via down-regulation of SREBP1, FAS and SCD1 mRNA levels and increased beta-oxidation via up-regulation of PPAR alpha and CPT2 mRNA levels.
   CONCLUSION: Probiotic L. curvatus HY7601 and L. plantarum KY1032 combined suppressed the clinical characteristics of high-fructose-induced metabolic syndrome, therefore, may provide a natural alternative for the treatment of diet-induced metabolic syndrome. (C) 2013 Baishideng. All rights reserved.
C1 [Park, Do-Young; Ahn, Young-Tae; Huh, Chul-Sung] Korea Yakult Co Ltd, Yongin 449901, Gyeonggi, South Korea.
   [McGregor, Robin A.; Choi, Myung-Sook] Kyungpook Natl Univ, Dept Food Sci & Nutr, Ctr Food & Nutr Genom, Taegu 702701, South Korea.
C3 Kyungpook National University (KNU)
RP Choi, MS (corresponding author), Kyungpook Natl Univ, Dept Food Sci & Nutr, Ctr Food & Nutr Genom, 1370 Sankyuk Dong, Taegu 702701, South Korea.
EM mschoi@knu.ac.kr
RI McGregor, Robin/H-5857-2011
OI Park, Do-Young/0000-0002-4170-4835
FU Basic Science Research Program, Center for Food and Nutritional
   Genomics, the National Research Foundation (NRF) of Korea; Ministry of
   Education, Science and Technology [2011-0000912]; Korea Yakult Co., Ltd
FX Supported by The Basic Science Research Program, Center for Food and
   Nutritional Genomics, the National Research Foundation (NRF) of Korea
   funded by the Ministry of Education, Science and Technology, No.
   2011-0000912 and Korea Yakult Co., Ltd.
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NR 36
TC 58
Z9 66
U1 1
U2 44
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 7041 Koll Center Parkway, Suite 160, PLEASANTON, CA, UNITED STATES
SN 1007-9327
EI 2219-2840
J9 WORLD J GASTROENTERO
JI World J. Gastroenterol.
PD JAN 14
PY 2013
VL 19
IS 2
BP 274
EP 283
DI 10.3748/wjg.v19.i2.274
PG 10
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 069FP
UT WOS:000313421000017
PM 23345951
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Kohn, JN
   Cabrera, Y
   Dimitrov, S
   Guay-Ross, N
   Pruitt, C
   Shaikh, FD
   Hong, SZ
AF Kohn, Jordan N.
   Cabrera, Yesenia
   Dimitrov, Stoyan
   Guay-Ross, Nicholas
   Pruitt, Christopher
   Shaikh, Farah D.
   Hong, Suzi
TI Sex-specific roles of cellular inflammation and cardiometabolism in
   obesity-associated depressive symptomatology
SO INTERNATIONAL JOURNAL OF OBESITY
LA English
DT Article
ID C-REACTIVE PROTEIN; METABOLIC SYNDROME; PSYCHIATRIC-DISORDERS;
   MEDITERRANEAN DIET; RISK-FACTORS; STRESS; SYMPTOMS; LEPTIN; MEN;
   DYSREGULATION
AB Background Obesity and depression are complex conditions with stronger comorbid relationships among women than men. Inflammation and cardiometabolic dysfunction are likely mechanistic candidates for increased depression risk, and their prevalence differs by sex. Whether these relationships extend to depressive symptoms is poorly understood. Therefore, we analyzed sex in associations between inflammation and metabolic syndrome (MetS) criteria on depressive symptomatology. Specifically, we examined whether sex positively moderates the relationship between depressive symptoms and inflammation among women, and whether MetS has parallel effects among men.
   Methods Depressive symptoms, MetS, and inflammation were assessed in 129 otherwise healthy adults. Depressive symptoms were assessed using Beck Depression Inventory (BDI-Ia). Monocyte inflammation regulation (BARIC) was quantified using flow cytometry measurement of TNF-alpha suppression by n-agonist. Moderation effects of sex on associations between BARIC, MetS criteria, and BDI were estimated using two-way ANOVA and linear regression, adjusting for BMI, and by sex subgroup analyses.
   Results Obese individuals reported more depressive symptoms. Sex did not formally moderate this relationship, though BDI scores tended to differ by BMI among women, but not men, in subgroup analysis. Poorer inflammation control and higher MetS criteria were correlated with somatic depressive symptoms. Sex moderated associations between MetS criteria and somatic symptoms; among men, MetS criteria predicted somatic symptoms, not among women. Subgroup analysis further indicated that poorer inflammation control tended to be associated with higher somatic symptoms in women.
   Conclusions These results indicate that obesity-related inflammation and MetS factors have sex-specific effects on depressive symptoms in a non-clinical population. Although pathophysiological mechanisms underlying sex differences remain to be elucidated, our findings suggest that distinct vulnerabilities to depressive symptoms exist between women and men, and highlight the need to consider sex as a key biological variable in obesity-depression relationships. Future clinical studies on comorbid obesity and depression should account for sex, which may optimize therapeutic strategies.
C1 [Kohn, Jordan N.; Guay-Ross, Nicholas; Shaikh, Farah D.; Hong, Suzi] Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA.
   [Cabrera, Yesenia] Univ Calif Los Angeles, Neurosci Interdept PhD Program, Los Angeles, CA 90095 USA.
   [Dimitrov, Stoyan] Univ Tubingen, Inst Med Psychol & Behav Neurobiol, D-72076 Tubingen, Germany.
   [Pruitt, Christopher; Hong, Suzi] Univ Calif San Diego, Dept Family Med & Publ Hlth, La Jolla, CA 92093 USA.
C3 University of California System; University of California San Diego;
   University of California System; University of California Los Angeles;
   Eberhard Karls University of Tubingen; Eberhard Karls University
   Hospital; University of California System; University of California San
   Diego
RP Hong, SZ (corresponding author), Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA.; Hong, SZ (corresponding author), Univ Calif San Diego, Dept Family Med & Publ Hlth, La Jolla, CA 92093 USA.
EM s1hong@ucsd.edu
OI Cabrera, Yesenia/0000-0003-1423-7538; Dimitrov,
   Stoyan/0000-0002-1184-1441; Kohn, Jordan/0000-0001-8546-2076
FU National Institutes of Health [UL1RR031980, TL1TR001443, R01HL090975,
   HL090975S1]
FX This work was partially supported by the research grants R01HL090975
   (SH) and HL090975S1 (American Recovery and Reinvestment Act grant; SH),
   UL1RR031980 for the UCSD Clinical and Translational Science Awards, and
   TL1TR001443 (JNK) from the National Institutes of Health.
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NR 63
TC 15
Z9 16
U1 0
U2 5
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0307-0565
EI 1476-5497
J9 INT J OBESITY
JI Int. J. Obes.
PD OCT
PY 2019
VL 43
IS 10
BP 2045
EP 2056
DI 10.1038/s41366-019-0375-3
PG 12
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA JB3ZC
UT WOS:000488494400018
PM 31089263
OA Green Accepted, Green Submitted
DA 2025-06-11
ER

PT J
AU van der Lubbe, A
   Swaab, H
   Vermeiren, RRJM
   Ester, WA
AF van der Lubbe, Anna
   Swaab, Hanna
   Vermeiren, Robert R. J. M.
   Ester, Wietske A.
TI Stress, Eating Behavior and Adverse Health in Parents of Young Children
   with Autism Spectrum Disorder
SO JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
LA English
DT Article
DE Autism Spectrum Disorder; Parenting Stress; Eating Behavior; Adverse
   Health; Early Childhood; Fathers
ID METABOLIC SYNDROME; MOTHERS; ASSOCIATIONS; ADOLESCENTS; DIVISION;
   FATHERS; RISK
AB Mothers of children with Autism Spectrum Disorder (ASD) often experience chronic stress and are at risk for adverse health. However, little is known about fathers, especially when their child is in early childhood. Parenting stress, eating behavior and physical health was evaluated in mothers (n = 48) and fathers (n = 43) of young children (3-7 years) with ASD by questionnaires and physical measurements. Mother's prevalence rates of obesity (39.1%), abdominal obesity (59.6%) and metabolic syndrome (21.6%) were higher than the norm. In fathers, the prevalence rate of clinical parenting stress (33%) was higher than the norm. Parenting stress was positively related to disinhibited eating in mothers, not in fathers. It is crucial to monitor stress and health of parents of children with ASD.
C1 [van der Lubbe, Anna; Swaab, Hanna; Ester, Wietske A.] Sarr Expert Ctr Autism Youz Child & Adolescent Ps, Parnassia Grp, Dynamostr 18, Rotterdam, Netherlands.
   [van der Lubbe, Anna; Swaab, Hanna] Leiden Univ, Clin Neurodev Sci, Wassenaarseweg 52, Leiden, Netherlands.
   [Ester, Wietske A.] Parnassia Acad, Parnassia Grp, The Hague, Netherlands.
   [Vermeiren, Robert R. J. M.; Ester, Wietske A.] Curium LUMC, Child & Adolescent Psychiat, Endegeesterstraatweg 27, Oegstgeest, Netherlands.
   [Swaab, Hanna] Leiden Univ, Leiden Inst Brain & Cognit, Leiden, Netherlands.
C3 Parnassia Psychiatric Institute; Leiden University; Leiden University -
   Excl LUMC; Parnassia Psychiatric Institute; Leiden University; Leiden
   University Medical Center (LUMC); Leiden University - Excl LUMC; Leiden
   University; Leiden University Medical Center (LUMC)
RP van der Lubbe, A (corresponding author), Sarr Expert Ctr Autism Youz Child & Adolescent Ps, Parnassia Grp, Dynamostr 18, Rotterdam, Netherlands.; van der Lubbe, A (corresponding author), Leiden Univ, Clin Neurodev Sci, Wassenaarseweg 52, Leiden, Netherlands.
EM a.vanderlubbe@youz.nl
RI Swaab, Hanna/AAD-2555-2019; Ester, Wietske/JZE-1102-2024
OI Vermeiren, Robert/0000-0002-8673-2207; van der Lubbe,
   Anna/0000-0002-7693-0701
FU Korczac Foundation for Autism and Related Disorders and Stichting tot
   Steun VCVGZ
FX The authors would like to acknowledge funding received from the Korczac
   Foundation for Autism and Related Disorders and Stichting tot Steun
   VCVGZ. With special thanks to all parents and children who participated
   in this study
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NR 36
TC 11
Z9 11
U1 3
U2 22
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0162-3257
EI 1573-3432
J9 J AUTISM DEV DISORD
JI J. Autism Dev. Disord.
PD FEB
PY 2024
VL 54
IS 2
BP 662
EP 672
DI 10.1007/s10803-022-05825-3
EA NOV 2022
PG 11
WC Psychology, Developmental
WE Social Science Citation Index (SSCI)
SC Psychology
GA GG5J0
UT WOS:000888695200002
PM 36434479
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Peng, Y
   Gu, T
   Zhong, T
   Xiao, Y
   Sun, QC
AF Peng, Ye
   Gu, Ting
   Zhong, Tian
   Xiao, Ying
   Sun, Quancai
TI Endoplasmic reticulum stress in metabolic disorders: opposite roles of
   phytochemicals and food contaminants
SO CURRENT OPINION IN FOOD SCIENCE
LA English
DT Article
ID ER STRESS; PATHWAY
AB Endoplasmic reticulum (ER) stress is a temporary disruption of ER homeostasis, which acts as a protective response of cells. However, prolonged ER stress is a critical factor in the pathogenesis of metabolic syndrome, including diabetes, obesity, and their related disorders. Recently, a vast array of research has focused on the effects of plant-based components on alleviating ER stress by suppressing unfolded protein response signaling pathways, such as hesperidin, tectorigenin, resveratrol, naringenin, and vitexin, thus exhibiting protective effects on metabolic disorders. Meanwhile, several food contaminants such as insecticides (including pyrethroids and neonicotinoids) have been found to aggravate ER-stress -induced neuronal apoptosis and further lead to neurotoxicity. In this review, the opposite roles of phytochemicals and food contaminants and their underlying mechanisms related to ER stress have been summarized in order to come up with potential strategies to prevent the increasing prevalence of metabolic syndrome.
C1 [Peng, Ye; Zhong, Tian; Xiao, Ying] Macau Univ Sci & Technol, Fac Med, Taipa, Macao, Peoples R China.
   [Peng, Ye; Gu, Ting; Sun, Quancai] Jiangsu Univ, Sch Food & Biol Engn, Zhenjiang, Jiangsu, Peoples R China.
   [Sun, Quancai] Natl Univ Singapore, Dept Food Sci & Technol, Singapore, Singapore.
C3 Macau University of Science & Technology; Jiangsu University; National
   University of Singapore
RP Zhong, T (corresponding author), Macau Univ Sci & Technol, Fac Med, Taipa, Macao, Peoples R China.; Sun, QC (corresponding author), Jiangsu Univ, Sch Food & Biol Engn, Zhenjiang, Jiangsu, Peoples R China.; Sun, QC (corresponding author), Natl Univ Singapore, Dept Food Sci & Technol, Singapore, Singapore.
EM tzhong@must.edu.mo; sqctp@hotmail.com
RI Xiao, Ying/ADV-0522-2022; peng, ye/GXZ-9245-2022
FU National Natural Science Foundation of China [31801641]
FX Acknowledgements This research was partly supported by funding from
   National Natural Science Foundation of China (31801641) .
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NR 42
TC 3
Z9 3
U1 3
U2 17
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 2214-7993
EI 2214-8000
J9 CURR OPIN FOOD SCI
JI Curr. Opin. Food Sci.
PD DEC
PY 2022
VL 48
AR 100913
DI 10.1016/j.cofs.2022.100913
EA SEP 2022
PG 8
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA 4Z8XM
UT WOS:000862484100008
DA 2025-06-11
ER

PT J
AU Gertz, K
   Uhlemann, R
   Foryst-Ludwig, A
   Barrientos, RM
   Kappert, K
   Thöne-Reineke, C
   Djoufack, P
   Kirschbaum, C
   Fink, KB
   Heinz, A
   Kintscher, U
   Endres, M
   Kronenberg, G
AF Gertz, Karen
   Uhlemann, Ria
   Foryst-Ludwig, Anna
   Barrientos, Ruben Marquina
   Kappert, Kai
   Thoene-Reineke, Christa
   Djoufack, Pierre
   Kirschbaum, Clemens
   Fink, Klaus B.
   Heinz, Andreas
   Kintscher, Ulrich
   Endres, Matthias
   Kronenberg, Golo
TI The cytoskeleton in 'couch potato-ism': Insights from a murine model of
   impaired actin dynamics
SO EXPERIMENTAL NEUROLOGY
LA English
DT Article
DE actin; corticosterone; depression; hypoactivity; metabolic syndrome;
   obesity
ID NITRIC-OXIDE SYNTHASE; METABOLIC SYNDROME; CELL-DEATH; MICE; GELSOLIN;
   STRESS; HYPERTENSION; ORGANIZATION; HIPPOCAMPAL; COMPONENTS
AB Evidence for a critical pathophysiological role of aberrant cytoskeletal dynamics is being uncovered in a growing number of neuropsychiatric syndromes. A sedentary lifestyle as well as overt psychopathology is prevalent in patients with the metabolic syndrome. Using mice deficient in gelsolin (Gsn(-/-)), a crucial actin-severing protein, we here investigated reduced actin turnover as a potential common driver of metabolic disturbances, sedentary behavior, and an anxious/depressive phenotype. Gelsolin deficiency resulted in reduced lifespan. As compared to wildtype controls, Gsn(-/-) mice (similar to 9 weeks) fed a high-fat diet (HFD) over a span of 12 weeks showed increased body weight gain, fat mass, hepatic steatosis, and adipocyte hypertrophy as well as a significantly reduced respiratory quotient. Moreover, increased rigidity of the actin cytoskeleton in mice on HFD induced mRNA expression of Acc1, Acc2, Fasn, and Lipe, key genes involved in fatty acid metabolism in the liver. Glucose tolerance and insulin sensitivity were worsened in Gsn(-/-) HFD relative to Gsn(+/+) HFD mice. Hypertension in Gsn(-/-) mice was associated with reduced endothelial NO synthase (eNOS) mRNA expression and reduced eNOS protein trafficking to the plasma membrane. Furthermore, acetylcholine-induced cGMP production and relaxation of aortic rings were impaired by actin filament stabilization. Gsn(-/-) mice on HFD displayed reduced corticosterone concentrations and reduced energy expenditure as compared to Gsn(+/+) HFD mice. Moreover, Gsn(-/-) HFD mice displayed an overall pattern of hypoactive and anxious/depressive-like behavior. In aggregate, our results demonstrate that impaired actin filament dynamics promote the development of key behavioral and physiological aspects of the metabolic syndrome.
C1 [Gertz, Karen; Uhlemann, Ria; Barrientos, Ruben Marquina; Endres, Matthias] Humboldt Univ, Freie Univ Berlin, Charite Univ Med Berlin, Berlin Inst Hlth,Klin & Hochschulambulanz Neurol, D-10117 Berlin, Germany.
   [Gertz, Karen; Uhlemann, Ria; Barrientos, Ruben Marquina; Endres, Matthias] CSB, D-10117 Berlin, Germany.
   [Foryst-Ludwig, Anna; Kintscher, Ulrich] Humboldt Univ, Freie Univ Berlin, Charite Univ Med Berlin, Berlin Inst Hlth,Inst Pharmakol,CCR, D-10117 Berlin, Germany.
   [Foryst-Ludwig, Anna; Kintscher, Ulrich; Endres, Matthias] DZHK German Ctr Cardiovasc Res, Partner Site Berlin, D-10115 Berlin, Germany.
   [Kappert, Kai] Humboldt Univ, Freie Univ Berlin, Charite Univ Med Berlin, D-10117 Berlin, Germany.
   [Kappert, Kai] Klin Chem & Pathobiochem, Inst Laboratoriumsmed, Berlin Inst Hlth, CCR, D-10117 Berlin, Germany.
   [Thoene-Reineke, Christa] Free Univ Berlin, Inst Tierschutz Tierverhalten & Versuchstierkunde, D-14163 Berlin, Germany.
   [Djoufack, Pierre; Fink, Klaus B.] Univ Klinikum Bonn, Inst Pharmakol, D-53113 Bonn, Germany.
   [Kirschbaum, Clemens] Tech Univ Dresden, Inst Biol Psychol, D-01062 Dresden, Germany.
   [Heinz, Andreas; Kronenberg, Golo] Humboldt Univ, Freie Univ Berlin, Charite Univ Med Berlin, Berlin Inst Hlth,Klin Psychiat & Psychotherapie, D-10117 Berlin, Germany.
   [Endres, Matthias] DZNE, D-10117 Berlin, Germany.
   [Kronenberg, Golo] Univ Med Rostock, Klin & Poliklin Psychiat & Psychotherapie, D-18147 Rostock, Germany.
C3 Berlin Institute of Health; Free University of Berlin; Humboldt
   University of Berlin; Charite Universitatsmedizin Berlin; Berlin
   Institute of Health; Free University of Berlin; Humboldt University of
   Berlin; Charite Universitatsmedizin Berlin; German Centre for
   Cardiovascular Research; Berlin Institute of Health; Free University of
   Berlin; Humboldt University of Berlin; Charite Universitatsmedizin
   Berlin; Berlin Institute of Health; Free University of Berlin; Humboldt
   University of Berlin; Charite Universitatsmedizin Berlin; Free
   University of Berlin; University of Bonn; Technische Universitat
   Dresden; Berlin Institute of Health; Free University of Berlin; Humboldt
   University of Berlin; Charite Universitatsmedizin Berlin; Helmholtz
   Association; German Center for Neurodegenerative Diseases (DZNE);
   University of Rostock
RP Gertz, K (corresponding author), Klin Neurol, Charite Campus Mitte,Charitepl 1, D-10117 Berlin, Germany.
EM karen.gertz@charite.de
RI Kronenberg, Golo/F-8772-2010; Heinz, Andreas/ABB-7736-2020; Kirschbaum,
   Clemens/AAB-1752-2020; Gertz, Karen/J-1603-2015
OI Kintscher, Ulrich/0000-0001-7386-0990; Endres,
   Matthias/0000-0001-6520-3720; Gertz, Karen/0000-0002-1203-641X; Heinz,
   Andreas/0000-0001-5405-9065; Gottert, Ria/0000-0003-4756-7381
FU Deutsche Forschungsgemeinschaft [SFB TRR43, Exc257, KR 2956/4-1,
   2576/2-1]; Bundesministerium fur Bildung und Forschung [CSB 01 EO 1301];
   German Center for Neurodegenerative Diseases (DZNE); German Center for
   Cardiovascular Research (DZHK); Corona Foundation
FX This work was supported by the Deutsche Forschungsgemeinschaft (SFB
   TRR43 and Exc257 to M.E.; KR 2956/4-1 to G.K.; 2576/2-1 to K.G.), the
   Bundesministerium fur Bildung und Forschung (CSB 01 EO 1301 to M.E.,
   K.G. and G.K.), the German Center for Neurodegenerative Diseases (DZNE
   to M.E.), the German Center for Cardiovascular Research (DZHK to M.E.
   and U.K), and the Corona Foundation (to M.E.).
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NR 68
TC 4
Z9 5
U1 0
U2 9
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0014-4886
EI 1090-2430
J9 EXP NEUROL
JI Exp. Neurol.
PD AUG
PY 2018
VL 306
BP 34
EP 44
DI 10.1016/j.expneurol.2018.04.004
PG 11
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA GK7IQ
UT WOS:000436373600004
PM 29684438
DA 2025-06-11
ER

PT J
AU Wang, F
   Wang, L
   Wang, YF
   Li, D
   Hu, TP
   Sun, MY
   Lei, P
AF Wang, Feng
   Wang, Lu
   Wang, Yifeng
   Li, Dai
   Hu, Tianpeng
   Sun, Manyi
   Lei, Ping
TI Exogenous IGF-1 improves cognitive function in rats with high-fat diet
   consumption
SO JOURNAL OF MOLECULAR ENDOCRINOLOGY
LA English
DT Article
DE cAMP-response element binding protein; cognitive function; high-fat
   diet; insulin-like growth factor-1; oxidative stress
ID METABOLIC SYNDROME; SIGNALING PATHWAY; INDUCED APOPTOSIS; OXIDATIVE
   STRESS; IN-VIVO; IMPAIRMENT; ACTIVATION; DECLINE; RISK; IDENTIFICATION
AB Insulin-like growth factor-1 (IGF-1) improves cognitive function, but its mechanism has not been elucidated. The aim of the study was to explore whether IGF-1 exerted its protective effect on cognitive function and anxiety behavior through the activation of PI3K/Akt/CREB pathway in high-fat diet rats. Neuronal cells HT22 were treated with nothing, IGF-1, IGF-1 + LY294002 or IGF-1 + 666-15. Expressions of p-PI3K, p-Akt and p-CREB were measured using Western blot analysis. Thirty C57BL/6J rats were used. After feeding with high-fat diet, normal saline, PEG-IGF-1, PEG-IGF-1 + LY294002 or PEG-IGF-1 + 666-15 was treated. Cognitive function and anxiety behavior were assessed by Morris water maze and open field test. Several inflammation and oxidative stress biomarkers were measured using recognized methods. Expressions of p-PI3K and p-CREB were also measured using Western blot analysis. After IGF-1 treatment in cells, expressions of p-PI3K, p-Akt and p-CREB were increased. Furthermore, LY294002 downregulated the expressions of these three proteins, but 666-15 only inhibited the expression of CREB in the cells. Compared with the control rats, we found abnormalities of cognitive function and anxiety behavior, inhibition of PI3K/Akt/CREB pathway and increase of oxidative stress and inflammation in high-fat diet rats. After PEG-IGF-1 treatment, the changes in high-fat diet rats were reversed. Then, we blocked the pathway and found that these blockers attenuated the protective effects of PEG-IGF-1. In conclusion, IGF-1 improved cognitive function and anxiety behavior in high-fat diet rats and inhibited inflammation and oxidative stress in hippocampus tissue through the activation of PI3K/Akt/CREB pathway.
C1 [Wang, Feng; Wang, Lu; Wang, Yifeng; Li, Dai; Hu, Tianpeng; Lei, Ping] Tianjin Med Univ, Tianjin Geriatr Inst, Dept Geriatr, Gen Hosp, Tianjin, Peoples R China.
   [Sun, Manyi] Tianjin United Med Ctr, Dept Digest, Tianjin, Peoples R China.
   [Sun, Manyi] Tianjin Peoples Hosp, Tianjin, Peoples R China.
C3 Tianjin Medical University
RP Lei, P (corresponding author), Tianjin Med Univ, Tianjin Geriatr Inst, Dept Geriatr, Gen Hosp, Tianjin, Peoples R China.
EM leiping_1974@163.com
RI 王, 逸峰/HDO-2385-2022; Hu, Peng/GQA-9639-2022
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NR 31
TC 15
Z9 16
U1 0
U2 15
PU BIOSCIENTIFICA LTD
PI BRISTOL
PA STARLING HOUSE, 1600 BRISTOL PARKWAY N, BRISTOL, ENGLAND
SN 0952-5041
EI 1479-6813
J9 J MOL ENDOCRINOL
JI J. Mol. Endocrinol.
PD FEB
PY 2020
VL 64
IS 2
BP 115
EP 123
DI 10.1530/JME-19-0150
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA KE3CP
UT WOS:000508437300006
PM 31855559
DA 2025-06-11
ER

PT J
AU Zietzer, A
   Hillmeister, P
AF Zietzer, A.
   Hillmeister, P.
TI ExActa Leucocyte telomere length as marker for cardiovascular ageing
SO ACTA PHYSIOLOGICA
LA English
DT Article
ID OXIDATIVE STRESS; MYOCARDIAL-INFARCTION; INSULIN-RESISTANCE; METABOLIC
   SYNDROME; HYPERTENSIVE-RATS; PHYSICAL-ACTIVITY; HEME OXYGENASE-1;
   UP-REGULATION; RISK-FACTORS; ATHEROSCLEROSIS
C1 [Zietzer, A.] Charite, Ctr Cardiovasc Res, D-13353 Berlin, Germany.
   Richard Thoma Labs Arteriogenesis, Expt & Clin Res Ctr, Berlin, Germany.
C3 Berlin Institute of Health; Free University of Berlin; Humboldt
   University of Berlin; Charite Universitatsmedizin Berlin
RP Zietzer, A (corresponding author), Charite, Ctr Cardiovasc Res, D-13353 Berlin, Germany.
EM andreas.zietzer@charite.de
RI Hillmeister, Philipp/JGL-8056-2023; Zietzer, Andreas/KXQ-4775-2024
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NR 68
TC 12
Z9 12
U1 0
U2 12
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1748-1708
EI 1748-1716
J9 ACTA PHYSIOL
JI Acta Physiol.
PD JUN
PY 2014
VL 211
IS 2
BP 251
EP 256
DI 10.1111/apha.12284
PG 6
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA AH1WE
UT WOS:000335911600002
PM 24666613
DA 2025-06-11
ER

PT J
AU Menter, MA
   Armstrong, AW
   Gordon, KB
   Wu, JJ
AF Menter, M. Alan
   Armstrong, April W.
   Gordon, Kenneth B.
   Wu, Jashin J.
TI Common and Not-So-Common Comorbidities of Psoriasis
SO SEMINARS IN CUTANEOUS MEDICINE AND SURGERY
LA English
DT Article
DE Cardiovascular disease; comorbidities; immune-mediated disorders;
   overweight/obesity; psoriasis; psoriatic arthritis; psychiatric
   disorders
ID MYOCARDIAL-INFARCTION; METABOLIC SYNDROME; DOUBLE-BLIND; RISK;
   PREVALENCE; ARTHRITIS; MODERATE; INHIBITORS; MORTALITY; DISEASES
AB Plaque psoriasis is increasingly recognized as a multisystemic disease whose most common comorbidities include psoriatic arthritis, cardiovascular disease, metabolic syndrome, overweight/obesity, inflammatory bowel disease, and depression The presence of such comorbidities affects the therapeutic choices for clinicians Patients often visit dermatologists more frequently than they do other clinicians, so it is incumbent upon dermatologists to recognize and address early signs of psoriatic comorbidities to prevent further deterioration and improve their patients' quality of life.
C1 [Menter, M. Alan] Baylor Univ, Med Ctr, Div Dermatol, Dallas, TX USA.
   [Armstrong, April W.] Univ Southern Calif, Keck Sch Med, Dermatol Clin, Los Angeles, CA USA.
   [Armstrong, April W.] Univ Southern Calif, Keck Sch Med, Clin Res, Los Angeles, CA USA.
   [Gordon, Kenneth B.] Med Coll Wisconsin, Dept Dermatol, Milwaukee, WI 53226 USA.
   [Wu, Jashin J.] Kaiser Permanente Los Angeles, Med Ctr, Dept Dermatol, Dermatol Res, Los Angeles, CA USA.
C3 Baylor University; Baylor University Medical Center; University of
   Southern California; University of Southern California; Medical College
   of Wisconsin; Kaiser Permanente; University of California System;
   University of California Los Angeles; University of California Los
   Angeles Medical Center
RP Menter, MA (corresponding author), 3900 Junius St,Suite 145, Dallas, TX 75246 USA.
EM amderm@gmail.com
FU Ortho Dermatologics
FX Publication of this CME/CE article was jointly provided by University of
   Louisville, Postgraduate Institute for Medicine, and Global Academy for
   Medical Education, LLC, and is supported by an educational grant from
   Ortho Dermatologics. The authors have received an honorarium for their
   participation in this activity. They acknowledge the editorial
   assistance of Suzanne Bujara, medical writer, and Global Academy for
   Medical Education in the development of this continuing medical
   education journal article.
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NR 39
TC 3
Z9 3
U1 0
U2 5
PU FRONTLINE MEDICAL COMMUNICATIONS
PI THE WOODLANDS
PA WRIGHTS MEDIA, 2407 TIMBERLOCH PLACE, SUITE B, THE WOODLANDS, TX 77386
   USA
SN 1085-5629
EI 1558-0768
J9 SEMIN CUTAN MED SURG
JI Semin. Cutan. Med. Surg.
PD MAR
PY 2018
VL 37
IS 2
SU 2
BP S49
EP S52
DI 10.12788/j.sder.2018.01l
PG 4
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA GF4OM
UT WOS:000431942200004
DA 2025-06-11
ER

PT J
AU Innes, KE
   Vincent, HK
AF Innes, Kim E.
   Vincent, Heather K.
TI The influence of yoga-based programs on risk profiles in adults with
   type 2 diabetes mellitus: A systematic review
SO EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Review
DE blood pressure; cardiovascular disease; coagulation; glycemia; insulin
   resistance; lipids; lung function; oxidative stress; sympathetic
   activity
ID INSULIN-RESISTANCE SYNDROME; CORONARY-HEART-DISEASE; SYMPATHETIC
   NERVOUS-SYSTEM; BODY-FAT DISTRIBUTION; CARDIOVASCULAR-DISEASE; METABOLIC
   SYNDROME; DEPRESSIVE SYMPTOMS; OXIDATIVE STRESS; LUNG-FUNCTION;
   HATHA-YOGA
AB There is growing evidence that yoga may offer a safe and cost-effective intervention for Type 2 Diabetes mellitus (DM 2). However, systematic reviews are lacking. This article critically reviews the published literature regarding the effects of yoga-based programs on physiologic and anthropometric risk profiles and related clinical outcomes in adults with DM 2. We performed a comprehensive literature search using four computerized English and Indian scientific databases. The search was restricted to original studies (1970-2006) that evaluated the metabolic and clinical effects of yoga in adults with DM 2. Studies targeting clinical populations with cardiovascular disorders that included adults with comorbid DM were also evaluated. Data were extracted regarding study design, setting, target population, intervention, comparison group or condition, outcome assessment, data analysis and presentation, follow-up, and key results, and the quality of each study was evaluated according to specific predetermined criteria. We identified 25 eligible studies, including 15 uncontrolled trials, 6 non-randomized controlled trials and 4 randomized controlled trials (RCTs). Overall, these studies suggest beneficial changes in several risk indices, including glucose tolerance and insulin sensitivity, lipid profiles, anthropometric characteristics, blood pressure, oxidative stress, coagulation profiles, sympathetic activation and pulmonary function, as well as improvement in specific clinical outcomes. Yoga may improve risk profiles in adults with DM 2, and may have promise for the prevention and management of cardiovascular complications in this population. However, the limitations characterizing most studies preclude drawing firm conclusions. Additional high-quality RCTs are needed to confirm and further elucidate the effects of standardized yoga programs in populations with DM 2.
C1 [Innes, Kim E.] Univ Virginia Hlth Syst, Ctr Study Complementary & Alternat Therapies, Blake Ctr, Charlottesville, VA 22908 USA.
   [Innes, Kim E.; Vincent, Heather K.] Univ Virginia Hlth Syst, Dept Phys Med & Rehabil, Charlottesville, VA 22908 USA.
C3 University of Virginia; University of Virginia (UVA) Health System;
   University of Virginia; University of Virginia (UVA) Health System
RP Vincent, HK (corresponding author), Univ Virginia Hlth Syst, Ctr Study Complementary & Alternat Therapies, Blake Ctr, Suite G113,POB 800905, Charlottesville, VA 22908 USA.
EM kei6n@virginia.edu
RI Vincent, Heather/ABH-4566-2020
OI Vincent, Heather/0000-0003-2177-1683
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NR 146
TC 137
Z9 164
U1 0
U2 25
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1741-427X
EI 1741-4288
J9 EVID-BASED COMPL ALT
JI Evid.-based Complement Altern. Med.
PD DEC
PY 2007
VL 4
IS 4
BP 469
EP 486
DI 10.1093/ecam/nel103
PG 18
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA 255NZ
UT WOS:000252666000011
PM 18227915
OA Green Published, Green Submitted, hybrid
DA 2025-06-11
ER

PT J
AU Finlay, S
   Rudd, D
   McDermott, B
   Sarnyai, Z
AF Finlay, Sabine
   Rudd, Donna
   McDermott, Brett
   Sarnyai, Zoltan
TI Allostatic load and systemic comorbidities in psychiatric disorders
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE Mental health; Psychiatric disorders; Comorbidities; Allostatic load
ID MAJOR DEPRESSIVE DISORDER; POSTTRAUMATIC-STRESS-DISORDER;
   LONG-TERM-POTENTIATION; QUALITY-OF-LIFE; METABOLIC SYNDROME; BIPOLAR
   DISORDER; INSULIN-RESISTANCE; EXCESS MORTALITY; MOOD DISORDERS;
   IMMUNE-SYSTEM
AB Psychiatric disorders are complex, disabling, and chronic conditions that are often accompanied by one or more systemic medical comorbidities. In this narrative review, we provide an overview of the allostatic load concept, which represents a multi-system dysregulation in response to chronic stress and link it to systemic comorbidities associated with psychiatric disorders. We synthesized published literature gathered using Medline (Ovid), Sco-pus, and PsychInfo and identified a high frequency of systemic comorbidities for both mood and psychotic disorders. The identified cardiovascular, metabolic, and immune comorbidities may represent the result of chronic wear and tear caused by a complex interaction between chronic psychosocial stress, health risk be-haviors, pharmacological stressors, and the biological systems involved in the development of allostatic load. These findings support the notion that psychiatric disorders should be re-conceptualized as systemic disorders, affecting the brain and systemic biological pathways in an interconnected fashion to result in systemic comor-bidities. We suggest that the multi-systemic and multi-dimensional approach that drives the allostatic load concept should be considered for understanding comorbidities in vulnerable psychiatric patients.
C1 [Finlay, Sabine; Rudd, Donna; Sarnyai, Zoltan] James Cook Univ, Ctr Mol Therapeut, Lab Psychiat Neurosci, Townsville, Qld, Australia.
   [Finlay, Sabine; Rudd, Donna; Sarnyai, Zoltan] James Cook Univ, Australian Inst Trop Hlth & Med, Townsville, Qld, Australia.
   [Finlay, Sabine; Rudd, Donna; Sarnyai, Zoltan] James Cook Univ, Coll Publ Hlth Med & Vet Sci, 1 James Cook Dr, Townsville, Qld 4811, Australia.
   [McDermott, Brett] James Cook Univ, Coll Med & Dent, Townsville, Qld, Australia.
C3 James Cook University; James Cook University; James Cook University;
   James Cook University
RP Sarnyai, Z (corresponding author), James Cook Univ, Coll Publ Hlth Med & Vet Sci, 1 James Cook Dr, Townsville, Qld 4811, Australia.
EM zoltan.sarnyai@jcu.edu.au
RI Rudd, Donna/AAA-8595-2022; Finlay, Sabine/LIA-7797-2024; Sarnyai,
   Zoltan/A-3283-2009
OI Finlay, Sabine/0009-0004-6590-6943; Sarnyai, Zoltan/0000-0002-2380-7902
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NR 196
TC 24
Z9 24
U1 0
U2 8
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
EI 1873-3360
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD JUN
PY 2022
VL 140
AR 105726
DI 10.1016/j.psyneuen.2022.105726
EA MAR 2022
PG 12
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA 1W2DL
UT WOS:000806588100001
PM 35339811
DA 2025-06-11
ER

PT J
AU Balagopal, P
AF Balagopal, Prabhakaran
TI Physical activity and cardiovascular health in children
SO PEDIATRIC ANNALS
LA English
DT Article
ID C-REACTIVE PROTEIN; AMERICAN-DIABETES-ASSOCIATION;
   CORONARY-HEART-DISEASE; RISK-FACTORS; CARDIORESPIRATORY FITNESS;
   METABOLIC SYNDROME; VISCERAL ADIPOSITY; OXIDATIVE STRESS;
   BODY-COMPOSITION; OVERWEIGHT
C1 Nemours Childrens Clin, Jacksonville, FL 32207 USA.
   Mayo Clin Coll Med, Jacksonville, FL 32207 USA.
C3 Mayo Clinic
RP Balagopal, P (corresponding author), Nemours Childrens Clin, 807 Childrens Way, Jacksonville, FL 32207 USA.
EM bbalagop@nemours.org
RI Balagopal, Babu/AAT-4777-2021
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NR 45
TC 2
Z9 4
U1 0
U2 5
PU SLACK INC
PI THOROFARE
PA 6900 GROVE RD, THOROFARE, NJ 08086 USA
SN 0090-4481
EI 1938-2359
J9 PEDIATR ANN
JI Pediatr. Ann.
PD NOV
PY 2006
VL 35
IS 11
BP 814
EP +
DI 10.3928/0090-4481-20061101-09
PG 9
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA 104PG
UT WOS:000241970000008
PM 17153128
DA 2025-06-11
ER

PT J
AU Ghike, SM
AF Ghike, Shrikant Madhukar
TI Metabolic syndrome - A truly psychosomatic disorder? A global hypothesis
SO MEDICAL HYPOTHESES
LA English
DT Article
DE Clinical psychiatry; Metabolic syndrome; Cardio vascular disease;
   Hyperglycaemia; Type 2 diabetes mellitus; Lactic acidosis
ID CORONARY-ARTERY-DISEASE; DIABETES-MELLITUS; MONKEYS; DEPRESSION;
   ALLOSTASIS; REACTIVITY; SEROTONIN; BIOLOGY; STRESS; RISK
AB Exact cause of the metabolic syndrome [MS], a global epidemic, is still unclear. Man has same fundamental needs to live as animals but modern man's life-style compels him to acquire certainty of resources for all his needs in a complex social network. Today money has become the sole life essential need. Contrarily none of the animals needs to earn money.
   Brain is also an organ of the human body with a unique thought process to define logical actions to achieve a person's goals. This way life is a flow of desires followed by logical actions. The person struggles to attain desired goals via the allostatic load but a perceived insurmountable threat can make his flow of life stalled to freeze him.
   Published data from varied branches of medical science indicates role of hormones in overall homeostasis. Particularly multifaceted role of serotonin is well documented. Adrenalin being the primary mediator of Cod cycle is also well known. From the integration of observations from published data with reference to common human's modern lifestyle, it is hypothesized that a perceived trapped situation in life creates acute chaos of thoughts in brain, which results in acute excess of stress hormones and concurrent depletion of resting hormones, which in turn triggers MS. In global terms, MS indicates an acute imbalance of a few hormones and implies psychosomatic roots of the disorder. This may pave a better way in deciding a personalized holistic protocol with combination of counter regulatory psychoactive medications. (C) 2016 Elsevier Ltd. All rights reserved.
C1 [Ghike, Shrikant Madhukar] Natl Chem Lab, CE & PD Div, Dr Homi Bhabha Rd, Pune 411008, Maharashtra, India.
C3 Council of Scientific & Industrial Research (CSIR) - India; CSIR -
   National Chemical Laboratory (NCL)
RP Ghike, SM (corresponding author), Natl Chem Lab, CE & PD Div, Dr Homi Bhabha Rd, Pune 411008, Maharashtra, India.
EM sm.ghike@ncl.res.in
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NR 40
TC 3
Z9 3
U1 0
U2 3
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0306-9877
EI 1532-2777
J9 MED HYPOTHESES
JI Med. Hypotheses
PD DEC
PY 2016
VL 97
BP 46
EP 53
DI 10.1016/j.mehy.2016.10.015
PG 8
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Research & Experimental Medicine
GA ED9CD
UT WOS:000389166900011
PM 27876129
DA 2025-06-11
ER

PT J
AU Arce, M
   Michopoulos, V
   Shepard, KN
   Ha, QC
   Wilson, ME
AF Arce, Marilyn
   Michopoulos, Vasiliki
   Shepard, Kathryn N.
   Ha, Quynh-Chau
   Wilson, Mark E.
TI Diet choice, cortisol reactivity, and emotional feeding in socially
   housed rhesus monkeys
SO PHYSIOLOGY & BEHAVIOR
LA English
DT Article
DE Social subordination; Psychosocial stress; Food intake; Anxiety;
   Cortisol
ID CORTICOTROPIN-RELEASING-FACTOR; FEMALE CYNOMOLGUS MONKEYS; HIGH-FAT
   DIET; PITUITARY-ADRENAL AXIS; SEROTONIN REUPTAKE TRANSPORTER;
   POSITRON-EMISSION-TOMOGRAPHY; DOPAMINERGIC SYSTEM ACTIVITY; CRF RECEPTOR
   ANTAGONIST; FOOD-INTAKE; ABDOMINAL OBESITY
AB Chronic psychosocial stress produces an array of adverse health consequences that are highly comorbid including emotional eating affective disorders and metabolic syndrome The consumption of high caloric diets (HCDs) is thought to provide comfort in the face of unrelenting psychosocial stress Using social subordination in female rhesus monkeys as a model of continual exposure to daily stressors in women we tested the hypothesis that subordinate females would consume significantly more calories from a HCD compared to dominant females and this pattern of food intake would be associated with reduced cortisol release and reduced frequency of anxiety-like behaviors Food intake parameters of cortisol secretion and socio-emotional behavior were assessed for 3 weeks during a no choice phase when only a low caloric diet (LCD) was available and during a choice condition when both a LCD and HCD were available While all animals preferred the HCD subordinate females consumed significantly more of the HCD than did dominant females A flattening of the diurnal cortisol rhythm and a greater increase in serum cortisol to an acute social separation occurred during the diet choice condition in all females Furthermore the rate of anxiety-like behavior progressively declined during the 3-week choice condition in subordinate but not dominant females These data provide support for the hypothesis that daily exposure to psychosocial stress Increases consumption of calorically dense foods Furthermore consumption of HCDs may be a metabolic stressor that synergizes with the psychosocial stress of subordination to further increase the consumption of these diets (C) 2010 Elsevier Inc. All rights reserved
C1 [Michopoulos, Vasiliki; Shepard, Kathryn N.; Wilson, Mark E.] Emory Univ, Yerkes Natl Primate Res Ctr, Atlanta, GA 30329 USA.
   [Arce, Marilyn] Emory Univ, Sch Med, Dept Anim Resources, Atlanta, GA 30322 USA.
   [Ha, Quynh-Chau] Emory Univ, Dept Anthropol, Atlanta, GA 30322 USA.
C3 Emory University; Emory University; Emory University
RP Wilson, ME (corresponding author), Emory Univ, Yerkes Natl Primate Res Ctr, 954 Gatewood Rd, Atlanta, GA 30329 USA.
RI Michopoulos, Vasiliki/C-7342-2014
OI Michopoulos, Vasiliki/0000-0003-2531-923X
FU NIH [HD46501, 4425 RR024505, T32-MH073525, K12 GM000680, RR00165]
FX The authors thank Jennifer Whitley Marta Checchi Shannon Moss and Jeff
   Fisher for the expert technical assistance This work was funded by NIH
   grants HD46501 training grant numbers 4425 RR024505 (MA) T32-MH073525
   (VM) and K12 GM000680 and in part RR00165 Further support was provided
   by the Center for Behavioral Neuroscience through the STC Program of the
   National Science Foundation IBN-9876754 The YNPRC is fully accredited by
   AAALAC International
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NR 110
TC 68
Z9 83
U1 0
U2 17
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0031-9384
J9 PHYSIOL BEHAV
JI Physiol. Behav.
PD NOV 2
PY 2010
VL 101
IS 4
BP 446
EP 455
DI 10.1016/j.physbeh.2010.07.010
PG 10
WC Psychology, Biological; Behavioral Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Behavioral Sciences
GA 677HK
UT WOS:000283979500006
PM 20670639
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Zhang, DM
   Jiao, RQ
   Kong, LD
AF Zhang, Dong-Mei
   Jiao, Rui-Qing
   Kong, Ling-Dong
TI High Dietary Fructose: Direct or Indirect Dangerous Factors Disturbing
   Tissue and Organ Functions
SO NUTRIENTS
LA English
DT Review
DE high dietary fructose; metabolites; metabolic syndrome; insulin
   resistance; oxidative stress; inflammation; tissue and organ dysfunction
ID FATTY LIVER-DISEASE; INDUCED INSULIN-RESISTANCE; PROTEIN-KINASE-C; NLRP3
   INFLAMMASOME ACTIVATION; INDUCED HEPATIC STEATOSIS; VISCERAL
   ADIPOSE-TISSUE; NECROSIS-FACTOR-ALPHA; NF-KAPPA-B; URIC-ACID; OXIDATIVE
   STRESS
AB High dietary fructose is a major contributor to insulin resistance and metabolic syndrome, disturbing tissue and organ functions. Fructose is mainly absorbed into systemic circulation by glucose transporter 2 (GLUT2) and GLUT5, and metabolized in liver to produce glucose, lactate, triglyceride (TG), free fatty acid (FFA), uric acid (UA) and methylglyoxal (MG). Its extrahepatic absorption and metabolism also take place. High levels of these metabolites are the direct dangerous factors. During fructose metabolism, ATP depletion occurs and induces oxidative stress and inflammatory response, disturbing functions of local tissues and organs to overproduce inflammatory cytokine, adiponectin, leptin and endotoxin, which act as indirect dangerous factors. Fructose and its metabolites directly and/or indirectly cause oxidative stress, chronic inflammation, endothelial dysfunction, autophagy and increased intestinal permeability, and then further aggravate the metabolic syndrome with tissue and organ dysfunctions. Therefore, this review addresses fructose-induced metabolic syndrome, and the disturbance effects of direct and/or indirect dangerous factors on the functions of liver, adipose, pancreas islet, skeletal muscle, kidney, heart, brain and small intestine. It is important to find the potential correlations between direct and/or indirect risk factors and healthy problems under excess dietary fructose consumption.
C1 [Zhang, Dong-Mei; Jiao, Rui-Qing; Kong, Ling-Dong] Nanjing Univ, Sch Life Sci, State Key Lab Pharmaceut Biotechnol, Nanjing 210023, Jiangsu, Peoples R China.
C3 Nanjing University
RP Kong, LD (corresponding author), Nanjing Univ, Sch Life Sci, State Key Lab Pharmaceut Biotechnol, Nanjing 210023, Jiangsu, Peoples R China.
EM zdm@nju.edu.cn; jiaorq@nju.edu.cn; kongld@nju.edu.cn
FU National Natural Science Foundation of China [81573667, 81673488];
   National Basic Research Program of China 973 Program [2012CB517600,
   2012CB517602]; Program for Changjiang Scholars and Innovative Research
   Team in University [IRT 14R27]
FX This work was supported by grants from the National Natural Science
   Foundation of China (No. 81573667 and 81673488), National Basic Research
   Program of China 973 Program No. 2012CB517600 (No. 2012CB517602), and
   the Program for Changjiang Scholars and Innovative Research Team in
   University (IRT 14R27) to Ling-Dong Kong.
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NR 183
TC 166
Z9 181
U1 6
U2 54
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD APR
PY 2017
VL 9
IS 4
AR 335
DI 10.3390/nu9040335
PG 25
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA EU9JI
UT WOS:000401355600020
PM 28353649
OA gold, Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Han, L
   Bittner, S
   Dong, DC
   Cortez, Y
   Bittner, A
   Chan, J
   Umar, M
   Shen, WJ
   Peterson, RG
   Kraemer, FB
   Azhar, S
AF Han, Lu
   Bittner, Stefanie
   Dong, Dachuan
   Cortez, Yuan
   Bittner, Alex
   Chan, Jackie
   Umar, Meenakshi
   Shen, Wen-Jun
   Peterson, Richard G.
   Kraemer, Fredric B.
   Azhar, Salman
TI Molecular changes in hepatic metabolism in ZDSD rats-A new polygenic
   rodent model of obesity, metabolic syndrome, and diabetes
SO BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
LA English
DT Article
DE Metabolic syndrome; Type 2 diabetes; Insulin resistance; ER stress; ZDSD
ID ENDOPLASMIC-RETICULUM STRESS; ER STRESS; LIPID-METABOLISM; CELL-DEATH;
   EXPRESSION; MANAGEMENT; LIVER; GLYCOLYSIS; CHILDREN; ENZYMES
AB In recent years, the prevalence of obesity, metabolic syndrome and type 2 diabetes is increasing dramatically. They share pathophysiological mechanisms and often lead to cardiovascular diseases. The ZDSD rat was suggested as a new animal model to study diabetes and the metabolic syndrome. In the current study, we have further characterized metabolic and hepatic gene expression changes in ZDSD rats. Immuno-histochemical staining of insulin and glucagon on pancreas sections of ZDSD and control SD rats revealed that ZDSD rats have severe damage to their islet structures as early as 15 weeks of age. Animals were followed till they were 26 weeks old, where they exhibited obesity, hypertension, hyperglycemia, dyslipidemia, insulin resistance and diabetes. We found that gene expressions involved in glucose metabolism, lipid metabolism and amino acid metabolism were changed significantly in ZDSD rats. Elevated levels of ER stress markers correlated with the dysregulation of hepatic lipid metabolism in ZDSD rats. Key proteins participating in unfolded protein response pathways were also upregulated and likely contribute to the pathogenesis of dyslipidemia and insulin resistance. Based on its intact leptin system, its insulin deficiency, as well as its timeline of disease development without diet manipulation, this insulin resistant, dyslipidemic, hypertensive, and diabetic rat represents an additional, unique polygenic animal model that could be very useful to study human diabetes.
C1 [Han, Lu; Bittner, Stefanie; Dong, Dachuan; Cortez, Yuan; Bittner, Alex; Chan, Jackie; Umar, Meenakshi; Shen, Wen-Jun; Kraemer, Fredric B.; Azhar, Salman] VA Palo Alto Hlth Care Syst, GRECC, 182B,3801 Miranda Ave, Palo Alto, CA 94304 USA.
   [Han, Lu; Dong, Dachuan; Chan, Jackie; Umar, Meenakshi; Shen, Wen-Jun; Kraemer, Fredric B.; Azhar, Salman] Stanford Univ, Div Endocrinol Gerontol & Metab, Sch Med, Stanford, CA 94305 USA.
   [Peterson, Richard G.] Crown Biosci Indiana, Indianapolis, IN USA.
   [Chan, Jackie] Abcam, Epit In Vitro Diagnost Div, Burlingame, CA USA.
   [Umar, Meenakshi] Sidra Med, Div Translat Med, Doha, Qatar.
C3 Geriatric Research Education & Clinical Center; US Department of
   Veterans Affairs; Veterans Health Administration (VHA); VA Palo Alto
   Health Care System; Stanford University; Sidra Medical & Research Center
RP Azhar, S (corresponding author), VA Palo Alto Hlth Care Syst, GRECC, 182B,3801 Miranda Ave, Palo Alto, CA 94304 USA.; Shen, WJ (corresponding author), Stanford Univ, Div Endocrinol, Sch Med, S025, Stanford, CA 94305 USA.
EM wenjun@stanford.edu; salman.azhar@va.gov
RI Umar, Meenakshi/AFV-9658-2022; Kraemer, Fredric/AAC-3633-2019; Shen,
   Wen-Jun/ACG-0761-2022
OI Shen, Wen-Jun/0000-0001-5150-1698; Kraemer, Fredric/0000-0003-2468-7807
FU National Institutes of Health (NHLBI) [1R01HL92473]; National Institutes
   of Health (NIDDK) [P30DK116074]; United States Department of Veterans
   Affairs, Biomedical Laboratory Research and Development Program
   [I01BX001923, I01BX000398, IK6BX004200]
FX This work was supported by the National Institutes of Health (NHLBI,
   Grant 1R01HL92473 [SA] and NIDDK, P30DK116074 [FBK]) and Merit Review
   Awards (#I01BX001923 [SA] and #I01BX000398 [FBK]), and a Senior Research
   Career Scientist award (#IK6BX004200) from the United States Department
   of Veterans Affairs, Biomedical Laboratory Research and Development
   Program.
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NR 68
TC 9
Z9 10
U1 1
U2 8
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0925-4439
EI 1879-260X
J9 BBA-MOL BASIS DIS
JI Biochim. Biophys. Acta-Mol. Basis Dis.
PD MAY 1
PY 2020
VL 1866
IS 5
AR 165688
DI 10.1016/j.bbadis.2020.165688
PG 15
WC Biochemistry & Molecular Biology; Biophysics; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Cell Biology
GA LG2PL
UT WOS:000527949200025
PM 31987840
OA Bronze, Green Accepted
DA 2025-06-11
ER

PT J
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   Ando, E.
   Asai, Y.
   Eguchi, H.
   Kobayashi, Y.
   Nishida, N.
   Arima, H.
   Shimazu, A.
   Tsutsumi, A.
TI Work-related psychosocial factors and metabolic syndrome onset among
   workers: a systematic review and meta-analysis
SO OBESITY REVIEWS
LA English
DT Review
DE metabolic syndrome; psychosocial; worker; workplace
ID CORONARY-HEART-DISEASE; NIGHT-SHIFT WORK; JOB STRAIN;
   CARDIOVASCULAR-DISEASE; DIABETES-MELLITUS; BLOOD-PRESSURE; CHRONIC
   STRESS; RISK; PREVALENCE; OBESITY
AB Background: Work-related psychosocial factors have been associated with metabolic syndrome. However, no systematic reviews or meta-analyses have evaluated this association.
   Methods: A systematic literature search was conducted, using PubMed, Embase, PsycINFO, PsycARTICLES and the Japan Medical Abstracts Society. Eligible studies included those that examined the previously mentioned association; had a longitudinal or prospective cohort design; were conducted among workers; provided sufficient data for calculating odds ratios, relative risks or hazard ratios with 95% confidence intervals; were original articles in English or Japanese; and were published no later than 2016. Study characteristics, exposure and outcome variables and association measures of studies were extracted by the investigators independently.
   Results: Among 4,664 identified studies, 8 were eligible for review and meta-analysis. The pooled risk of adverse work-related stress on metabolic syndrome onset was significant and positive (RR = 1.47; 95% CI, 1.22-1.78). Sensitivity analyses limiting only the effects of job strain and shift work also indicated a significant positive relationship (RR = 1.75; 95% CI, 1.09-2.79; and RR = 1.59; 95% CI, 1.00-2.54, P = 0.049 respectively).
   Conclusion: This study reveals a strong positive association between work-related psychosocial factors and an elevated risk of metabolic syndrome onset. The effects of job strain and shift work on metabolic syndrome appear to be significant.
C1 [Watanabe, K.; Sakuraya, A.; Kawakami, N.; Imamura, K.; Asai, Y.; Arima, H.] Univ Tokyo, Grad Sch Med, Dept Mental Hlth, Tokyo, Japan.
   [Ando, E.] Osaka Univ, Grad Sch Med, Dept Social & Environm Hlth, Div Environm Med & Populat Sci, Osaka, Japan.
   [Eguchi, H.; Tsutsumi, A.] Kitasato Univ, Dept Publ Hlth, Sch Med, Sagamihara, Kanagawa, Japan.
   [Kobayashi, Y.] Honda Motor Co Ltd, Tokyo, Japan.
   [Nishida, N.] Kyoto Ind Hlth Assoc, Kyoto, Japan.
   [Shimazu, A.] Kitasato Univ, Coll Liberal Arts & Sci, Ctr Human & Social Sci, Sagamihara, Kanagawa, Japan.
C3 University of Tokyo; The University of Osaka; Kitasato University; Honda
   Motor Company; Honda Japan; Kitasato University
RP Tsutsumi, A (corresponding author), Kitasato Univ, Sch Med, Dept Publ Hlth, Minami Ku, 1-15-1 Kitasato, Sagamihara, Kanagawa 2520374, Japan.
EM akizumi@kitasato-u.ac.jp
OI Watanabe, Kazuhiro/0000-0002-3342-6142; Imamura,
   Kotaro/0000-0003-2584-0666; Sakuraya, Asuka/0000-0002-1561-019X;
   Kobayashi, Yuka/0000-0002-8474-6162
FU Japan Society for the Promotion of Science [15J04085]; Ministry of
   Health, Labour and Welfare [180701-01]; Grants-in-Aid for Scientific
   Research [15J04085] Funding Source: KAKEN
FX This work was supported by a Grant-in-Aid for Scientific Research from
   the Japan Society for the Promotion of Science (15J04085) and Ministry
   of Health, Labour and Welfare (180701-01).
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NR 69
TC 50
Z9 52
U1 0
U2 28
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1467-7881
EI 1467-789X
J9 OBES REV
JI Obes. Rev.
PD NOV
PY 2018
VL 19
IS 11
BP 1557
EP 1568
DI 10.1111/obr.12725
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism
GA GX2NK
UT WOS:000447555800007
PM 30047228
DA 2025-06-11
ER

PT J
AU Santini, I
   Stratta, P
   D'Onofrio, S
   De Lauretis, I
   Santarelli, V
   Pacitti, F
   Rossi, A
AF Santini, Ilaria
   Stratta, Paolo
   D'Onofrio, Simona
   De lauretis, Ida
   Santarelli, Valeria
   Pacitti, Francesca
   Rossi, Alessandro
TI The metabolic syndrome in an Italian psychiatric sample: a retrospective
   chart review of inpatients treated with antipsychotics
SO RIVISTA DI PSICHIATRIA
LA English
DT Article
DE schizophrenia; bipolar disorder; depressive disorders; metabolic
   syndrome; overweight; obesity
ID CATIE SCHIZOPHRENIA TRIAL; DRUG-NAIVE PATIENTS; BIPOLAR-DISORDER;
   MENTAL-ILLNESS; RISK-FACTORS; PREVALENCE; 2ND-GENERATION; 1ST-EPISODE;
   ASSOCIATION; CHILDREN
AB Introduction. The metabolic syndrome (MS) is an area of interest for mental health research because individuals with mental illnesses have an increased risk of medical morbidity and mortality compared with the general population. This cross-sectional study is aimed to estimate the prevalence of metabolic syndrome in an Italian psychiatric sample, treated with different types of antipsychotics. Methods. The data were derived from medical records of patient with affective and non-affective psychosis, admitted to the Hospital of L'Aquila psychiatric ward, from January 2012 to July 2014. The sample refers to consecutive admissions of subjects of both sexes, aged over 18 years, receiving one or more antipsychotic treatment. The diagnosis of MS was established when the clinical subject at least three of the five diagnostic criteria of the Adult Treatment Panel (NCEP-ATP III) were met. Results. 389 subjects were evaluated. We report a MS prevalence of 27.5%. This figure is very close to the metabolic syndrome prevalence in the Italian general population quoted around 26%. The BMI values also are very similar in these two populations, despite a higher obesity rate in the clinical sample. The MS prevalence rates in subject with schizophrenia, bipolar disorders and depressive disorders were respectively 30.6%, 36.4% and 36.8%. No significant differences in MS, diabetes or dyslipidemia rates were found among the three diagnostic groups. We did not find differences in metabolic syndrome prevalence either in relation to psychotropic polypharmacy or in relation to typical or atypical antipsychotics. However the psychiatric females in the clinical sample tend to have higher obesity rate, with a sort of all or none distribution (i.e. more obesity, more normal weight, but less overweight) compared to the general population. Conclusions. These findings could be explained by the interaction of some sort of liability due to drug treatment, illness related lifestyles, gender and other interacting factors (e.g. genetic) with metabolic issues.
C1 [Pacitti, Francesca] ASL 1 Avezzano Sulmona LAquila, Dept Mental Hlth, Laquila, Italy.
   Univ Aquila, Dept Biotechnol & Appl Clin Sci DISCAB, I-67100 Laquila, Italy.
C3 University of L'Aquila
RP Pacitti, F (corresponding author), ASL 1 Avezzano Sulmona LAquila, Dept Mental Hlth, Laquila, Italy.
EM fpacitti@tin.it
RI Rossi, Alessandro/AAX-7607-2021; Pacitti, Francesca/AAH-1384-2019
OI Pacitti, Francesca/0000-0002-1634-5332; ROSSI,
   Alessandro/0000-0001-8723-7622; Stratta, Paolo/0000-0002-3337-1225
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NR 55
TC 13
Z9 15
U1 0
U2 18
PU PENSIERO SCIENTIFICO EDITOR
PI ROME
PA VIA BRADANO 3/C, 00199 ROME, ITALY
SN 0035-6484
EI 2038-2502
J9 RIV PSICHIATR
JI Riv. Psichiatr.
PD JAN-FEB
PY 2016
VL 51
IS 1
BP 37
EP 42
PG 6
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA DF7BO
UT WOS:000371512700006
PM 27030348
DA 2025-06-11
ER

PT J
AU McLaughlin, PJ
AF McLaughlin, Peter J.
TI Reports of the death of CB1 antagonists have been greatly exaggerated:
   recent preclinical findings predict improved safety in the treatment of
   obesity
SO BEHAVIOURAL PHARMACOLOGY
LA English
DT Review
DE appetite-suppressant drugs; cannabinoids; drug antagonism; drug inverse
   agonism; food intake; laboratory animal models; motivation; new drug
   approval; rimonabant
ID CANNABINOID RECEPTOR ANTAGONIST; CARDIOMETABOLIC RISK-FACTORS;
   FOOD-REINFORCED BEHAVIOR; INVERSE AGONIST TARANABANT; ACUTE ANORECTIC
   RESPONSE; ELEVATED PLUS-MAZE; BODY-WEIGHT GAIN; OVERWEIGHT PATIENTS;
   PREFRONTAL CORTEX; SR 141716A
AB CB1 antagonists, including rimonabant (SR 141716A), hold considerable therapeutic potential in the reduction of appetite and lipogenesis and in improving the metabolic profile of obese individuals and those with diabetes. However, rimonabant has not been approved in the USA because of its numerous side-effects, including depression and anxiety. Because of this, it is expected that fewer attempts will be made to introduce CB1 antagonists into the market. However, a 'second generation' of compounds has produced promising results in animal models in terms of these side-effects, and may pave the way toward new development and clinical testing of compounds that lack the side-effects of rimonabant. This new generation includes neutral CB1 antagonists, which likely have less intrinsic activity than clinically tested drugs, and peripherally restricted compounds. The current paper reviews the behavioral profile of rimonabant and related compounds, including a similarity in hypophagic effects with putative neutral antagonists and peripherally restricted antagonists. Emerging evidence of a lack of effects in models of nausea, anxiety, and depression is discussed. It is concluded that, with increasing emphasis on modeling the more troublesome side-effects of CB1 antagonists, safe, efficacious therapeutic targets may emerge. Further rigorous preclinical testing should be carried out. Behavioural Pharmacology 23:537-550 (c) 2012 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
C1 Edinboro Univ Penn, Dept Psychol, Edinboro, PA 16444 USA.
C3 Pennsylvania State System of Higher Education (PASSHE); Edinboro
   University
RP McLaughlin, PJ (corresponding author), Edinboro Univ Penn, Dept Psychol, Edinboro, PA 16444 USA.
EM pmclaughlin@edinboro.edu
RI McLaughlin, Peter/JMC-1537-2023
OI McLaughlin, Peter/0000-0002-8011-642X
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NR 176
TC 20
Z9 22
U1 0
U2 19
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0955-8810
EI 1473-5849
J9 BEHAV PHARMACOL
JI Behav. Pharmacol.
PD SEP
PY 2012
VL 23
IS 5-6
BP 537
EP 550
DI 10.1097/FBP.0b013e3283566a8c
PG 14
WC Behavioral Sciences; Neurosciences; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Behavioral Sciences; Neurosciences & Neurology; Pharmacology & Pharmacy
GA 985EL
UT WOS:000307246100008
PM 22743603
DA 2025-06-11
ER

PT J
AU Lotti, T
   Hercogova, J
   Prignano, F
AF Lotti, Torello
   Hercogova, Jana
   Prignano, Francesca
TI The concept of psoriatic disease: Can cutaneous psoriasis any longer be
   separated by the systemic comorbidities?
SO DERMATOLOGIC THERAPY
LA English
DT Article
DE Psoriasis; comorbidities; psoriatic arthritis; cardiovascular disease;
   metabolic syndrome; inflammatory bowel disease; depression
ID RISK; ASSOCIATION; LYMPHOMA; WEIGHT
AB Psoriasis is a general inflammatory status in which the skin is usually visibly involved. Recent papers show that several comorbidities, including psoriatic arthritis, metabolic syndrome, cancer, osteoporosis, cardiovascular disease, chronic inflammatory bowel disease etc., are significantly associated with psoriasis. Detecting association between psoriasis and comorbidities, properly evaluate confounders and make a correct distinction among absolute risk, relative risk and clinical relevance is mandatory, before embracing the fact the psoriasis is, in fact, a complex and common international disease.
C1 [Lotti, Torello] Univ Florence, Sch Med, Dept Dermatol Sci, I-50129 Florence, Italy.
   [Hercogova, Jana] Charles Univ Prague, Fac Med 2, Dept Dermatol, Prague, Czech Republic.
C3 University of Florence; Motol University Hospital; Charles University
   Prague
RP Lotti, T (corresponding author), Univ Florence, Sch Med, Dept Dermatol Sci, Via Lorenzo 2 Magnif 104, I-50129 Florence, Italy.
EM tlotti@unifi.it
OI Prignano, Francesca/0000-0002-5997-2045
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NR 16
TC 19
Z9 20
U1 0
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1396-0296
EI 1529-8019
J9 DERMATOL THER
JI Dermatol. Ther.
PD MAR-APR
PY 2010
VL 23
IS 2
BP 119
EP 122
DI 10.1111/j.1529-8019.2010.01305.x
PG 4
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 574RT
UT WOS:000276011200004
PM 20415818
DA 2025-06-11
ER

PT J
AU Misra, A
   Shrivastava, U
AF Misra, Anoop
   Shrivastava, Usha
TI Obesity and Dyslipidemia in South Asians
SO NUTRIENTS
LA English
DT Review
DE obesity; abdominal obesity; dyslipidemia; triglycerides; Asian Indians;
   high density lipoprotein cholesterol (HDL); South Asians; nutrition;
   physical activity; type 2 diabetes
ID CARDIOVASCULAR RISK-FACTORS; FATTY LIVER-DISEASE;
   MAGNETIC-RESONANCE-SPECTROSCOPY; CORONARY-HEART-DISEASE; C-REACTIVE
   PROTEIN; BODY-MASS INDEX; DENSITY-LIPOPROTEIN CHOLESTEROL;
   INSULIN-RESISTANCE-SYNDROME; ABDOMINAL ADIPOSE-TISSUE; NORTHERN INDIAN
   MALES
AB Obesity and dyslipidemia are emerging as major public health challenges in South Asian countries. The prevalence of obesity is more in urban areas than rural, and women are more affected than men. Further, obesity in childhood and adolescents is rising rapidly. Obesity in South Asians has characteristic features: high prevalence of abdominal obesity, with more intra-abdominal and truncal subcutaneous adiposity than white Caucasians. In addition, there is greater accumulation of fat at ectopic sites, namely the liver and skeletal muscles. All these features lead to higher magnitude of insulin resistance, and its concomitant metabolic disorders (the metabolic syndrome) including atherogenic dyslipidemia. Because of the occurrence of type 2 diabetes, dyslipidemia and other cardiovascular morbidities at a lower range of body mass index (BMI) and waist circumference (WC), it is proposed that cut-offs for both measures of obesity should be lower (BMI 23-24.9 kg/m(2) for overweight and 25 kg/m(2) for obesity, WC 80 cm for women and 90 cm for men for abdominal obesity) for South Asians, and a consensus guideline for these revised measures has been developed for Asian Indians. Increasing obesity and dyslipidemia in South Asians is primarily driven by nutrition, lifestyle and demographic transitions, increasingly faulty diets and physical inactivity, in the background of genetic predisposition. Dietary guidelines for prevention of obesity and diabetes, and physical activity guidelines for Asian Indians are now available. Intervention programs with emphasis on improving knowledge, attitude and practices regarding healthy nutrition, physical activity and stress management need to be implemented. Evidence for successful intervention program for prevention of childhood obesity and for prevention of diabetes is available for Asian Indians, and could be applied to all South Asian countries with similar cultural and lifestyle profiles. Finally, more research on pathophysiology, guidelines for cut-offs, and culturally-specific lifestyle management of obesity, dyslipidemia and the metabolic syndrome are needed for South Asians.
C1 [Misra, Anoop] Fortis C DOC Ctr Excellence Diabet Metab Dis & En, New Delhi 110048, India.
   [Misra, Anoop] Diabet Fdn India, New Delhi 110016, India.
   [Misra, Anoop; Shrivastava, Usha] Natl Diabet Obes & Cholesterol Fdn N DOC, New Delhi 110016, India.
RP Misra, A (corresponding author), Fortis C DOC Ctr Excellence Diabet Metab Dis & En, B-16 Chirag Enclave, New Delhi 110048, India.
EM anoopmisra@metabolicresearchindia.com; usha.shrivast@gmail.com
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NR 137
TC 161
Z9 177
U1 1
U2 34
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JUL
PY 2013
VL 5
IS 7
BP 2708
EP 2733
DI 10.3390/nu5072708
PG 26
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 274TD
UT WOS:000328628200025
PM 23863826
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Valtonen, M
   Laaksonen, DE
   Laukkanen, J
   Tolmunen, T
   Rauramaa, R
   Viinamäki, H
   Kauhanen, J
   Lakka, T
   Niskanen, L
AF Valtonen, Maarit
   Laaksonen, David E.
   Laukkanen, Jari
   Tolmunen, Tommi
   Rauramaa, Rainer
   Viinamaki, Heimo
   Kauhanen, Jussi
   Lakka, Timo
   Niskanen, Leo
TI Leisure-time physical activity, cardiorespiratory fitness and feelings
   of hopelessness in men
SO BMC PUBLIC HEALTH
LA English
DT Article
ID ISCHEMIC-HEART-DISEASE; MYOCARDIAL-INFARCTION; DEPRESSIVE SYMPTOMS;
   METABOLIC SYNDROME; DIABETES-MELLITUS; RISK; POPULATION; PREDICTORS;
   MORTALITY; HEALTH
AB Background: Leisure-time physical activity (LTPA) and cardiorespiratory fitness contribute to mental health. Hopelessness has been linked to impaired mental health, cardiovascular events and mortality. Previous studies have focused on physical exercise and depression. We examined the associations of LTPA and cardiorespiratory fitness with feelings of hopelessness.
   Methods: In this cross-sectional study leisure-time physical activity, maximal oxygen uptake (VO2max), hopelessness and cardiovascular risk factors were assessed in a population-based cohort of 2428 men aged 42-60 years old at baseline.
   Results: Men feeling more hopeless about their future and reaching goals were less physically active, less fit and had a higher prevalence of many cardiovascular risk factors than men with lower levels of hopelessness. In a logistic regression model adjusted for age, smoking, alcohol consumption, cardiovascular disease and socioeconomic status, men engaging in less than 60 min/week of moderate-to-vigorous LTPA were 37% (95% CI 11-67%) more likely to feel hopeless than those engaging in at least 2.5 h/wk of LTPA. After further adjusting for elevated depressive symptoms the association of LTPA and hopelessness remained significant. VO2max was also associated with hopelessness, but not after adjustment for depressive symptoms.
   Conclusion: Moderate and vigorous LTPA and cardiorespiratory fitness were inversely associated with hopelessness in these middle-aged men. These findings suggest that physical inactivity and poor cardiorespiratory fitness is an important associate of hopelessness, a distinct element of low subjective well-being.
C1 [Valtonen, Maarit] Cent Finland Cent Hosp, Dept Med, Jyvaskyla 40620, Finland.
   [Valtonen, Maarit; Laaksonen, David E.; Niskanen, Leo] Kuopio Univ Hosp, Dept Med, Kuopio 70211, Finland.
   [Laaksonen, David E.; Lakka, Timo] Univ Kuopio, Dept Physiol, Inst Biomed, Kuopio 70211, Finland.
   [Laukkanen, Jari; Kauhanen, Jussi] Univ Kuopio, Sch Publ Hlth & Clin Nutr, Kuopio 70211, Finland.
   [Tolmunen, Tommi; Viinamaki, Heimo] Kuopio Univ Hosp, Dept Psychiat, Kuopio 70211, Finland.
   [Rauramaa, Rainer; Lakka, Timo] Kuopio Res Inst Exercise Med, Kuopio 70100, Finland.
C3 Central Finland Central Hospital; Kuopio University Hospital; University
   of Eastern Finland; University of Eastern Finland Hospital; University
   of Eastern Finland; University of Eastern Finland; Kuopio University
   Hospital; University of Eastern Finland; University of Eastern Finland
   Hospital
RP Valtonen, M (corresponding author), Cent Finland Cent Hosp, Dept Med, Keskussairaalantie 19, Jyvaskyla 40620, Finland.
EM maarit.valtonen@likes.fi; david.laaksonen@uku.fi;
   jariantero.laukkanen@uku.fi; tommi.tolmunen@kuh.fi;
   rainer.rauramaa@uku.fi; heimo.viinamaki@kuh.fi; jussi.kauhanen@uku.fi;
   timo.lakka@uku.fi; leo.niskanen@kuh.fi
RI Laukkanen, Jari/N-2196-2019; Kauhanen, Jussi/ABC-4064-2021; Laukkanen,
   Jari/I-4528-2017
OI Lakka, Timo/0000-0002-9199-2871; Laukkanen, Jari/0000-0002-3738-1586
FU Academy of Finland [41471, 1041086, 2041022]; Ministry of Education of
   Finland [167/722/96, 157/722/97, 156/722/98]; National Heart, Lung and
   Blood Institute of the USA [HL44199]; Onni and Hilja Tuovinen
   Foundation; Hospital districts of Central Finland and Northern Savo
FX We thank the staff of the Research Institute of Public Health,
   University of Kuopio, and Kuopio Research Institute of Exercise Medicine
   for data collection in the KIHD study. The KIHD study was supported by
   grants from the Academy of Finland (grants 41471, 1041086 and 2041022),
   the Ministry of Education of Finland (grants 167/722/96, 157/722/97,
   156/722/98), and the National Heart, Lung and Blood Institute of the USA
   (grant HL44199). M. V. is supported by grant from Onni and Hilja
   Tuovinen Foundation and EVO grants from Hospital districts of Central
   Finland and Northern Savo.
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PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
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PY 2009
VL 9
AR 204
DI 10.1186/1471-2458-9-204
PG 7
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA 480UU
UT WOS:000268763200001
PM 19555509
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Horri, N
   Haghighi, S
   Hosseini, SM
   Zare, M
   Parvaresh, E
   Amini, M
AF Horri, Negar
   Haghighi, Sassan
   Hosseini, Seyed Mohsen
   Zare, Maryam
   Parvaresh, Ehsan
   Amini, Massoud
TI Stressful Life Events, Education, and Metabolic Syndrome in Women: Are
   They Related? A Study in First-Degree Relatives of Type 2 Diabetics
SO METABOLIC SYNDROME AND RELATED DISORDERS
LA English
DT Article
ID CORONARY-HEART-DISEASE; CARDIOVASCULAR-DISEASE; OBESITY; RISK
AB Background: Some reports show that the prevalence of metabolic syndrome is higher in poorly educated women. In our opinion, one probable reason for this is that these women experience more stressful events in their lives. We investigated the association between major stressful life events and the prevalence of metabolic syndrome and the effect of education on this relationship in women.
   Methods: This cross-sectional study included 35- to 55-year-old women who were first-degree relatives of type 2 diabetics. They were questioned about stressful events in their lives, their physical activities, and basic characteristics. In addition waist circumference, blood pressure, fasting blood sugar, triglyceride, total and high-density lipoprotein cholesterol (HDL-C) were measured. Metabolic syndrome was defined according to Adult Treatment Panel III (ATP III) criteria, and the number of stresses was compared between two groups of participants with and without metabolic syndrome.
   Results: Among the 351 study participants, the prevalence of metabolic syndrome was 28.9%. The mean number of stresses in the metabolic syndrome group was higher than in the nonmetabolic syndrome group at 3.82 +/- 2.67 and 3.14 +/- 2.35, respectively (P = 0.036). The prevalence of metabolic syndrome in subjects with eight or more stressful life events (46%) was greater compared to those who had experienced less than eight stresses (23.4%; P = 0.017). The relationship between stressful life events and the prevalence of metabolic syndrome was independent of the low level of education, but the prevalence of poorly educated women was associated with the number of stresses.
   Conclusion: Considering the probable association between stress and prevalence of metabolic syndrome, which itself increases the risk of cardiovascular diseases, educating high-risk people to cope with stresses may be beneficial in reducing the incidence of cardiovascular diseases and preventing the onset of metabolic syndrome.
C1 [Horri, Negar; Haghighi, Sassan; Zare, Maryam; Amini, Massoud] Isfahan Univ Med Sci, Endocrine & Metab Res Ctr, Esfahan 8187698191, Iran.
   [Hosseini, Seyed Mohsen] Isfahan Univ Med Sci, Dept Epidemiol & Biostat, Sch Publ Hlth, Esfahan 8187698191, Iran.
   [Parvaresh, Ehsan] Novo Nordisk Pars, Tehran, Iran.
C3 Isfahan University of Medical Sciences; Isfahan University of Medical
   Sciences; Novo Nordisk
RP Horri, N (corresponding author), Isfahan Univ Med Sci, Endocrine & Metab Res Ctr, Sedigheh Tahereh Res Complex,Khorram St, Esfahan 8187698191, Iran.
EM emrc@mui.ac.ir
RI Hosseini, Sayed/W-3432-2017; Amini, Massoud/C-5340-2013; Parvaresh Rizi,
   Ehsan/A-8189-2016
OI Amini, Massoud/0000-0003-4134-0960; Hosseini, Sayed
   Mohsen/0000-0002-2524-0284; Hosseini, Sayed Mohsen/0000-0001-8958-5882;
   Parvaresh Rizi, Ehsan/0000-0002-2513-8829
CR ALWAN A, 1995, WHO TECHNICAL PUBLIC, V22, P65
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NR 25
TC 13
Z9 13
U1 0
U2 3
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-4196
EI 1557-8518
J9 METAB SYNDR RELAT D
JI Metab. Syndr. Relat. Disord.
PD DEC
PY 2010
VL 8
IS 6
BP 483
EP 487
DI 10.1089/met.2010.0015
PG 5
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 688GN
UT WOS:000284837900004
PM 21034178
DA 2025-06-11
ER

PT J
AU Rutters, F
   Pilz, S
   Koopman, ADM
   Rauh, SP
   Pouwer, F
   Stehouwer, CDA
   Elders, PJ
   Nijpels, G
   Dekker, JM
AF Rutters, Femke
   Pilz, Stefan
   Koopman, Anitra D. M.
   Rauh, Simone P.
   Pouwer, Frans
   Stehouwer, Coen D. A.
   Elders, Petra J.
   Nijpels, Giel
   Dekker, Jacqueline M.
TI Stressful life events and incident metabolic syndrome: the Hoorn study
SO STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS
LA English
DT Article
DE Incident; metabolic syndrome; stressful life events; waist circumference
ID PITUITARY-ADRENAL-AXIS; PSYCHOSOCIAL STRESS; MORTALITY; RISK;
   PREVALENCE; OBESITY; HEALTH; POPULATION; PREDICTION; CORTISOL
AB Stressful life events are associated with the metabolic syndrome in cross-sectional studies, but prospective studies addressing this issue are rare and limited. We therefore evaluated whether the number of stressful life events is associated with incident metabolic syndrome. We assessed the association between the number of stressful life events experienced in the 5 years up until baseline and incident metabolic syndrome after 6.5 years at follow-up in the Hoorn study, a middle-aged and elderly population-based cohort. Participants with prevalent metabolic syndrome at baseline were excluded. Metabolic syndrome was defined according to the Adult Treatment Panel III, including fasting plasma glucose levels, HDL-C levels, triglyceride levels, waist circumference and hypertension. We included 1099 participants (47% male; age 60 +/- 7 years). During 6.5 years of follow-up, 238 participants (22%) developed the metabolic syndrome. Logistic regression adjusted for age, sex, education level and follow-up duration showed a positive association between the number of stressful life events at baseline and incident metabolic syndrome [OR 1.13 (1.01-1.27) per event, p = 0.049]. In addition, a Poisson model showed a significant positive association between the number of stressful life events at baseline and the number of metabolic syndrome factors at follow-up [OR 1.05 (1.01-1.11) per event, p = 0.018]. Finally, we observed a significant association between the number of stressful life events at baseline and waist circumference at follow-up [adjusted for confounders beta 0.86 (0.39-1.34) cm per event, p < 0.001]. Overall, we concluded that persons who reported more stressful life events at baseline had a significantly increased risk for developing metabolic syndrome during 6.5 years of follow-up, in a middle-aged and elderly population-based cohort.
C1 [Rutters, Femke; Koopman, Anitra D. M.; Rauh, Simone P.; Dekker, Jacqueline M.] Vrije Univ Amsterdam Med Ctr, Dept Epidemiol & Biostat, Amsterdam, Netherlands.
   [Rutters, Femke; Koopman, Anitra D. M.; Rauh, Simone P.; Elders, Petra J.; Nijpels, Giel; Dekker, Jacqueline M.] Vrije Univ Amsterdam Med Ctr, EMGO, Inst Hlth & Care Res, Amsterdam, Netherlands.
   [Pilz, Stefan] Med Univ Graz, Dept Internal Med, Div Endocrinol & Metab, Graz, Austria.
   [Pouwer, Frans] Tilburg Univ, Dept Med & Clin Psychol, Ctr Res Psychol Somat Dis CoRPS, NL-5000 LE Tilburg, Netherlands.
   [Stehouwer, Coen D. A.] Maastricht Univ, Med Ctr, Dept Internal Med, NL-6200 MD Maastricht, Netherlands.
   [Stehouwer, Coen D. A.] Maastricht Univ, Med Ctr, Cardiovasc Res Inst CARIM, NL-6200 MD Maastricht, Netherlands.
   [Elders, Petra J.; Nijpels, Giel] Vrije Univ Amsterdam Med Ctr, Dept Gen Practice, Amsterdam, Netherlands.
C3 Vrije Universiteit Amsterdam; VU UNIVERSITY MEDICAL CENTER; Vrije
   Universiteit Amsterdam; VU UNIVERSITY MEDICAL CENTER; Medical University
   of Graz; Tilburg University; Maastricht University; Maastricht
   University; Maastricht University Medical Centre (MUMC); Vrije
   Universiteit Amsterdam; VU UNIVERSITY MEDICAL CENTER
RP Rutters, F (corresponding author), Vrije Univ Amsterdam Med Ctr, Dept Epidemiol & Biostat, De Boelelaan 1089a, NL-1081 BT Amsterdam, Netherlands.
EM f.rutters@vumc.nl
RI Rauh, Simone/AAB-9565-2019; Stehouwer, Coen/AAB-3435-2021
OI Elders, Petra/0000-0002-5907-7219; Pouwer, Frans/0000-0002-8172-9818;
   Pilz, Stefan/0000-0002-7959-1311; Stehouwer, Coen/0000-0001-8752-3223;
   Nijpels, Giel/0000-0002-3679-9710
FU Dutch Diabetes Research Foundation; Dutch Organization of Scientific
   Research; Dutch Heart Foundation; Health Research and Development
   Council of Netherlands
FX The authors thank all participants and all individuals supporting and
   contributing to the Hoorn study. The Hoorn study has been made possible
   by the VU Amsterdam and the VUmc, and by grants from the Dutch Diabetes
   Research Foundation, the Dutch Organization of Scientific Research, The
   Dutch Heart Foundation, and the Health Research and Development Council
   of the Netherlands.
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   Fabre B, 2013, STRESS, V16, P16, DOI 10.3109/10253890.2012.676112
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   Lemmens SG, 2011, PHYSIOL BEHAV, V103, P157, DOI 10.1016/j.physbeh.2011.01.009
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NR 41
TC 23
Z9 26
U1 0
U2 17
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1025-3890
EI 1607-8888
J9 STRESS
JI Stress
PY 2015
VL 18
IS 5
BP 507
EP 513
DI 10.3109/10253890.2015.1064891
PG 7
WC Behavioral Sciences; Endocrinology & Metabolism; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Behavioral Sciences; Endocrinology & Metabolism; Neurosciences &
   Neurology
GA DD4JP
UT WOS:000369888600003
PM 26186032
DA 2025-06-11
ER

PT J
AU Zahran, AM
   Sayed, SK
   Abd El Hafeez, HA
   Khalifa, WA
   Mohamed, NA
   Hetta, HF
AF Zahran, Asmaa M.
   Sayed, Sohair K.
   Abd El Hafeez, Heba A.
   Khalifa, Walaa A.
   Mohamed, Nahed A.
   Hetta, Helal F.
TI Circulating microparticle subpopulation in metabolic syndrome: relation
   to oxidative stress and coagulation markers
SO DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
LA English
DT Article
DE circulating microparticles; metabolic syndrome; oxidative stress;
   coagulation; CVD
ID PLATELET-DERIVED MICROPARTICLES; C-REACTIVE PROTEIN; ENDOTHELIAL
   MICROPARTICLES; WAIST CIRCUMFERENCE; CUTOFF POINTS; RISK-FACTORS;
   DYSFUNCTION; INDIVIDUALS; ANGIOTENSIN; PREVALENCE
AB Background: Circulating microparticles (MPs) contribute to the pathogenesis of atherothrombotic disorders and are raised in cardiovascular diseases. Herein, we aimed to investigate the effect of moderate metabolic abnormalities in an early stage of metabolic syndrome (MetS) on the level of MP subpopulations and to study relationships between MP subpopulations and both oxidative stress and coagulation markers.
   Methods: Flow cytometry used to evaluate circulating MPs subpopulations in 40 patients with an early stage MetS and 30 healthy controls. ELISA was used to quantify plasminogen activator inhibitor type 1/tissue plasminogen activator (PAI-1/TPA) while plasma glutathione peroxidase (GPx) activity was measured spectrophotometrically.
   Results: Total MPs were significantly elevated in MetS (P<0.001). Glutathione peroxidase and PAI1/TPA activity was significantly increased in subjects with MetS (P<0.001). Waist circumference, diastolic blood pressure, and total cholesterol positively influenced levels of total MPs, platelet-derived microparticles, and endothelium-derived microparticles. Fasting blood glucose, cholesterol, triglycerides, and low-density lipoprotein positively influenced the coagulation factors (TPA, PAI1). However, high-density lipoprotein negatively influenced platelet-derived MPs and factors associated with fibrinolysis (TPA, PAI1).
   Conclusion: Elevated circulating MPs are associated with MetS abnormalities, oxidative stress and coagulation factors and may act as early predictor of metabolic syndrome with risk of cardiovascular disease.
C1 [Zahran, Asmaa M.] South Egypt Canc Inst, Dept Clin Pathol, Assiut, Egypt.
   [Sayed, Sohair K.; Abd El Hafeez, Heba A.] Assiut Univ, Dept Clin Pathol, Fac Med, Assiut, Egypt.
   [Khalifa, Walaa A.] Assiut Univ, Dept Internal Med, Fac Med, Assiut, Egypt.
   [Mohamed, Nahed A.] Assiut Univ, Dept Med Biochem, Fac Med, Assiut, Egypt.
   [Hetta, Helal F.] Assiut Univ, Dept Med Microbiol & Immunol, Fac Med, Assiut, Egypt.
   [Hetta, Helal F.] Univ Cincinnati, Coll Med, Dept Internal Med, 231 Albert B Sabin Way,POB 670595, Cincinnati, OH 45267 USA.
C3 Egyptian Knowledge Bank (EKB); Assiut University; Egyptian Knowledge
   Bank (EKB); Assiut University; Egyptian Knowledge Bank (EKB); Assiut
   University; Egyptian Knowledge Bank (EKB); Assiut University; Egyptian
   Knowledge Bank (EKB); Assiut University; University System of Ohio;
   University of Cincinnati
RP Hetta, HF (corresponding author), Univ Cincinnati, Coll Med, Dept Internal Med, 231 Albert B Sabin Way,POB 670595, Cincinnati, OH 45267 USA.
EM helal.hetta@uc.edu
RI Asmaa Zahran, professor/N-1920-2019; Abourehab, Mohammed/ABH-2907-2021;
   Hetta, Helal/U-6794-2019
OI Hetta, Helal F./0000-0001-8541-7304; Zahran, Asmaa/0000-0001-8471-6388
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NR 50
TC 16
Z9 16
U1 1
U2 4
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-7007
J9 DIABET METAB SYND OB
JI Diabetes Metab. Syndr. Obes.
PY 2019
VL 12
BP 485
EP 493
DI 10.2147/DMSO.S191750
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA HX3LD
UT WOS:000467292500001
PM 31043798
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Batrakoulis, A
   Jamurtas, AZ
   Draganidis, D
   Georgakouli, K
   Tsimeas, P
   Poulios, A
   Syrou, N
   Deli, CK
   Papanikolaou, K
   Tournis, S
   Fatouros, IG
AF Batrakoulis, Alexios
   Jamurtas, Athanasios Z.
   Draganidis, Dimitrios
   Georgakouli, Kalliopi
   Tsimeas, Panagiotis
   Poulios, Athanasios
   Syrou, Niki
   Deli, Chariklia K.
   Papanikolaou, Konstantinos
   Tournis, Symeon
   Fatouros, Ioannis G.
TI Hybrid Neuromuscular Training Improves Cardiometabolic Health and Alters
   Redox Status in Inactive Overweight and Obese Women: A Randomized
   Controlled Trial
SO ANTIOXIDANTS
LA English
DT Article
DE antioxidant capacity; blood lipids; glycemic control; interval exercise
   training; metabolic syndrome severity
ID OXIDATIVE STRESS RESPONSES; METABOLIC SYNDROME; FITNESS TRENDS;
   ADIPOSE-TISSUE; INTENSITY; EXERCISE; RESISTANCE; DISEASE; RISK;
   INFLAMMATION
AB This randomized controlled trial investigated the effects of a 5-month high-intensity hybrid-type neuromuscular training program with nontraditional implements on cardiometabolic health, redox status, and cardiovascular disease (CVD) risk in inactive overweight and obese women. Forty-nine inactive female participants with overweight and obesity (age: 36.4 & PLUSMN; 4.4 years; BMI: 29.1 & PLUSMN; 2.9 kg/m(2)) were randomly assigned to either a control (C, n = 21) or a training group (TR, n = 28). TR followed a 20-week supervised, progressive, time-efficient (3 days/week; 6-15 min net exercise time) program implementing loaded fundamental movement patterns with prescribed work-to-rest time intervals (20-40 s, 1:2, 1:1, 2:1) in a circuit fashion (2-3 rounds). Cardiometabolic risk factors were measured at baseline and post-training as secondary outcomes of a larger randomized controlled trial. At post-intervention, TR demonstrated favorable changes in resting heart rate (-7%, p = 0.043), high-density lipoprotein (+18.1%, p = 0.029), atherogenic index (-17%, p = 0.045), mean arterial pressure (-4.5%, p = 0.03), waist circumference (-6.2%, p = 0.005), waist-to-hip ratio (-4.6%; p = 0.015), metabolic syndrome severity score (-222%, p = 0.024), full 30-year CVD risk (-15.8%, p = 0.002) and hard 30-year CVD risk (-17.6%, p = 0.01), vascular age (-7.8%, p = 0.002), protein carbonyls (-45.7%, p = 0.001), catalase activity (+15.2%, p = 0.023), and total antioxidant capacity (+11.4%, p = 0.002) relative to C. Additionally, TR induced beneficial changes in fasting glucose (-3.4%, p = 0.002), homeostatic model assessment for insulin resistance (-15.7%, p < 0.001), diastolic blood pressure (-5.6%, p < 0.001), reduced glutathione (+39.8%, p < 0.001), 10-year CVD risk (-17.4%, p = 0.011), and total bilirubin (-21.7%, p < 0.001) compared to baseline. These results suggest that hybrid-type neuromuscular training may improve aspects of cardiometabolic health and antioxidant status in inactive overweight and obese women providing a time-efficient (~100 min/week) exercise approach in a real-world gym setting.</p>
C1 [Batrakoulis, Alexios; Jamurtas, Athanasios Z.; Draganidis, Dimitrios; Tsimeas, Panagiotis; Poulios, Athanasios; Syrou, Niki; Deli, Chariklia K.; Papanikolaou, Konstantinos; Fatouros, Ioannis G.] Univ Thessaly, Dept Phys Educ & Sport Sci, Trikala 42100, Greece.
   [Georgakouli, Kalliopi] Univ Thessaly, Dept Nutr & Dietet, Trikala 42100, Greece.
   [Tournis, Symeon] Natl & Kapodistrian Univ Athens, Lab Res Musculoskeletal Syst Th Garofalidis, Athens 14561, Greece.
C3 University of Thessaly; University of Thessaly; National & Kapodistrian
   University of Athens
RP Fatouros, IG (corresponding author), Univ Thessaly, Dept Phys Educ & Sport Sci, Trikala 42100, Greece.
EM abatrakoulis@uth.gr; ajamurt@uth.gr; dimidraganidis@gmail.com;
   kgeorgakouli@gmail.com; ptsimeas@pe.uth.gr; apoulios@pe.uth.gr;
   nikisyrou@pe.uth.gr; delixar@uth.gr; kpapanikolaou@uth.gr;
   stournis@med.uoa.gr; ifatouros@uth.gr
RI Deli, Chariklia/ABD-2677-2021; Jamurtas, Athanasios/Y-4568-2019;
   Georgakouli, Kalliopi/AAP-4336-2020; Papanikolaou,
   Konstantinos/AGA-5407-2022; Batrakoulis, Alexios/AAE-4820-2022; Syrou,
   Niki/AAF-9879-2019; Tsimeas, Panagiotis/AAE-3466-2020; Papanikolaou,
   Konstantinos/Q-1594-2018
OI TOURNIS, SYMEON/0000-0002-8301-324X; Syrou, Niki/0000-0002-0849-7272;
   Tsimeas, Panagiotis/0000-0001-5498-3119; Papanikolaou,
   Konstantinos/0000-0002-5062-9881; Draganidis,
   Dimitrios/0000-0002-2773-7729; Batrakoulis, Alexios/0000-0003-0844-1284;
   Georgakouli, Kalliopi/0000-0001-5545-9271; Poulios,
   Athanasios/0000-0003-3912-0045
FU Postgraduate Program of Study Exercise amp; Health: Assessment amp;
   Prescription, School of Physical Education and Sports Science,
   University of Thessaly, Greece
FX This study was partially funded by the Postgraduate Program of Study
   Exercise & Health: Assessment & Prescription, School of Physical
   Education and Sports Science, University of Thessaly, Greece.
CR [Anonymous], NONC DIS COUNTR PROF
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NR 63
TC 24
Z9 24
U1 1
U2 6
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD OCT
PY 2021
VL 10
IS 10
AR 1601
DI 10.3390/antiox10101601
PG 17
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA WS9CV
UT WOS:000715474800001
PM 34679738
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Nashar, K
   Nguyen, AP
   Jesri, A
   Morrow, JD
   Egan, BM
AF Nashar, K
   Nguyen, AP
   Jesri, A
   Morrow, JD
   Egan, BM
TI Angiotensin receptor blockade improves arterial distensibility and
   reduces exercise-induced pressor responses in obese hypertensive
   patients with the metabolic syndrome
SO AMERICAN JOURNAL OF HYPERTENSION
LA English
DT Article
DE angiotensin receptor blockade; metabolic syndrome; arterial compliance;
   hypertension; exercise blood pressure
ID 3RD NATIONAL-HEALTH; OXIDATIVE STRESS; BLOOD-PRESSURE; RISK-FACTORS;
   LOSARTAN; CHOLESTEROL; PREVALENCE; ANTAGONIST; RESISTANCE; MORTALITY
AB Patients with the metabolic syndrome have three or more of five cardiovascular risk factors and increased oxidative stress, arterial stiffness and pressor responses to exercise, which may contribute to their threefold greater risk for coronary heart disease. In addition to lowering basal blood pressure (BP), angiotensin receptor blockers (ARBs) may benefit metabolic syndrome patients by reducing oxidative stress, arterial stiffness, and pressor responses to exercise. Twelve patients, 7 women and 5 men, with the metabolic syndrome (aged 45 +/- 2 years, BP 145 +/- 5/85 +/- 2 mm Hg, waist girth 110 +/- 3 cm, triglycerides 186 +/- 23 mg/dL, HDL cholesterol 44 +/- 2 mg/dL, glucose 99 +/- 3 mg/dL) were studied off medications, while on modest sodium restriction (similar to 100 mmol/d). Patients were randomized to the ARB losartan or placebo for 3 weeks then crossed over to the complement for 3 weeks. Studies were performed at the end of each phase following an overnight fast. Serum lipids and biomarkers of oxidative stress (F2-isoprostanes, thiobarbituric acid reacting substances) were unchanged by losartan, whereas large artery elasticity at rest, measured with the HDI PulseWave, increased from 13.6 +/- 0.7 on placebo to 16.2 +/- 1.1 mL/mm Hg on losartan, P <.05. Losartan lowered systolic BP preexercise from 142 +/- 3 to 131 plusmn; 3 mm Hg (P <.001) and systolic BP after 6 min of treadmill exercise from 192 6 to 169 5 mm Hg (P <.001). Losartan lowered systolic BP (-23 +/- 3 nu - 11 +/- 2 mm Hg, P <.05) and pulse pressure (- 4 +/- 1 nu - 15 +/- 2 mm Hg, P <.05) more during exercise than rest. Losartan reduces the pressor response to exercise, perhaps by enhancing arterial compliance. In addition to lowering basal BP, angiotensin receptor blockade in patients with metabolic syndrome improves arterial compliance and reduces pressor reactivity to exercise. (C) 2004 American Journal of Hypertension, Ltd.
C1 Med Univ S Carolina, Dept Med, Charleston, SC 29425 USA.
   Med Univ S Carolina, Dept Pharmacol, Charleston, SC 29425 USA.
   Vanderbilt Univ, Sch Med, Dept Pharmacol, Nashville, TN USA.
   Vanderbilt Univ, Sch Med, Dept Med, Nashville, TN USA.
C3 Medical University of South Carolina; Medical University of South
   Carolina; Vanderbilt University; Vanderbilt University
RP Med Univ S Carolina, Dept Med, 96 Jonathan Lucas St,CSB 826H, Charleston, SC 29425 USA.
EM eganbm@musc.edu
FU NCI NIH HHS [CA77839] Funding Source: Medline; NCRR NIH HHS [RR01070]
   Funding Source: Medline; NHLBI NIH HHS [HL55782, HL04290, HL58794]
   Funding Source: Medline; NIDDK NIH HHS [DK26657, DK48831] Funding
   Source: Medline; NIGMS NIH HHS [GM42056] Funding Source: Medline
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NR 35
TC 24
Z9 26
U1 0
U2 2
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0895-7061
EI 1941-7225
J9 AM J HYPERTENS
JI Am. J. Hypertens.
PD JUN
PY 2004
VL 17
IS 6
BP 477
EP 482
DI 10.1016/j.amjhyper.2004.02.015
PG 6
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 826PD
UT WOS:000221840100001
PM 15177518
DA 2025-06-11
ER

PT J
AU Suzuki, K
   Ito, Y
   Inoue, T
   Hamajima, N
AF Suzuki, Koji
   Ito, Yoshinori
   Inoue, Takashi
   Hamajima, Nobuyuki
TI Inverse association of serum carotenoids with prevalence of metabolic
   syndrome among Japanese
SO CLINICAL NUTRITION
LA English
DT Article
DE Metabolic syndrome; Carotenoids; Obesity; Antioxidant; Cross-sectional
   studies
ID CARDIOVASCULAR-DISEASE MORTALITY; ELEVATED OXIDATIVE STRESS; 3RD
   NATIONAL-HEALTH; ANTIOXIDANT CONCENTRATIONS; INCIDENT HYPERTENSION;
   WAIST CIRCUMFERENCE; VISCERAL ADIPOSITY; INSULIN-RESISTANCE;
   CIGARETTE-SMOKING; ABDOMINAL OBESITY
AB Background & aims: Several epidemiological studies have shown that circulating antioxidant levels are inversely associated with metabolic syndrome status. The purpose of this study was to examine the association of serum carotenoid levels, which have potent antioxidant effects, with metabolic syndrome and metabolic syndrome components in Japanese subjects.
   Methods: We conducted a cross-sectional study of 931 subjects (318 men and 613 women), aged 39-70 years, who attended a health examination. Metabolic syndrome was defined according to the diagnostic definition from the Japanese Examination Committee of Criteria for Metabolic Syndrome, which was released in 2005. Serum carotenoids were measured by high-performance liquid chromatography.
   Results: A significantly lower odds ratio (OR) for metabolic syndrome was observed in the highest tertile of serum beta-cryptoxanthin (OR:0.45; 95% CI:0.22-0.93 in men and 0.41; 0.17-0.93 in women) and beta-carotene (OR:0.45; 95% CI:0.21-0.95 in men and 0.37; 0.15-0.83 in women) compared to the lowest tertiles, in both sexes, but no significant association was found in male smokers. In women, moreover, OR for metabolic syndrome in the highest tertile of serum zeaxanthin/lutein (OR:0.37; 95% CI:0.16-0.84) was significantly lower than in the lowest tertile. Serum levels of beta-cryptoxanthin, alpha-carotene, and beta-carotene were significantly decreased with an increasing number of metabolic syndrome components in both sexes.
   Conclusions: These findings indicate that carotenoids may be important factors in the prevention of metabolic syndrome in nonsmokers, but further studies are required in smokers. (C) 2010 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.
C1 [Suzuki, Koji; Inoue, Takashi] Fujita Hlth Univ, Sch Hlth Sci, Dept Publ Hlth, Aichi 4701192, Japan.
   [Ito, Yoshinori; Hamajima, Nobuyuki] Nagoya Univ, Grad Sch Med, Dept Prevent Med, Nagoya, Aichi 4648601, Japan.
C3 Fujita Health University; Nagoya University
RP Suzuki, K (corresponding author), Fujita Hlth Univ, Sch Hlth Sci, Dept Publ Hlth, 1-98 Dengakugakubo, Aichi 4701192, Japan.
EM ksuzuki@fujita-hu.ac.jp
RI Hamajima, Nobuyuki/I-7237-2014
OI Suzuki, Koji/0000-0002-3235-9558
FU Fujita Health University
FX This study was supported in part by a grant from Fujita Health
   University. We thank the participants and staff of the health
   examination program for residents of Yakumo-town, Hokkaido, Japan.
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NR 47
TC 50
Z9 58
U1 1
U2 14
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0261-5614
EI 1532-1983
J9 CLIN NUTR
JI Clin. Nutr.
PD JUN
PY 2011
VL 30
IS 3
BP 369
EP 375
DI 10.1016/j.clnu.2010.12.006
PG 7
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 785KI
UT WOS:000292227500017
PM 21216053
DA 2025-06-11
ER

PT J
AU de Melo, AF Jr
   Escouto, L
   Pimpao, AB
   Peixoto, P
   Brasil, G
   Ronchi, SN
   Pereira, SA
   Bissoli, NS
AF de Melo, Antonio Ferreira
   Escouto, Leonardo
   Pimpao, Antonio B.
   Peixoto, Pollyana
   Brasil, Girlandia
   Ronchi, Silas Nascimento
   Pereira, Sofia Azeredo
   Bissoli, Nazare Souza
TI Anabolic-androgen steroids: A possible independent risk factor to
   Cardiovascular, Kidney and Metabolic Syndrome
SO TOXICOLOGY AND APPLIED PHARMACOLOGY
LA English
DT Article
DE Oxidative stress; Inflammation; Cardiovascular; Kidney and metabolic
   syndrome; Renin angiotensin system; Anabolic-androgen steroids
ID RENIN-ANGIOTENSIN SYSTEM; FOCAL SEGMENTAL GLOMERULOSCLEROSIS;
   HIGH-DENSITY-LIPOPROTEIN; NANDROLONE-DECANOATE; OXIDATIVE STRESS;
   BLOOD-PRESSURE; INFLAMMATORY CYTOKINES; MEDIATED APOPTOSIS;
   GENE-EXPRESSION; CARDIAC DEATH
AB Millions of individuals make illicit use of anabolic-androgenic steroids (AAS), remaining a public health issue. It often leads to detrimental effects, including cardiovascular and renal diseases, besides hormonal and metabolic imbalances. The objective of this review is to emphasize the contribution of oxidative stress and inflammation to these effects and connect the findings of experimental animal studies with the alterations found in clinical contexts, in AAS users. The study's results showed that AAS promotes a redox disruption and a pro-inflammatory state on organs that are involved in important physiologic processes. These drugs increase inflammatory high- sensitivity C-reactive protein (hs-CRP) and cytokines that contribute to the progression of atherosclerosis, cardiovascular disease risk or endpoints, including stroke, myocardial infarction and death. In the kidney, the AAS increase proteinuria and structural damage. Studies have linked AAS abuse with high BP, low HDL-C levels, high triglyceride levels and impaired fasting blood glucose that characterize Metabolic syndrome. Overall, the studies indicate that oxidative stress, apoptosis, and AAS-mediated inflammation play a significant role in tissue damage, regardless of the dose and duration of exposure, and we point it as a putative independent risk factor to Cardiovascular, Kidney and Metabolic syndrome.
C1 [de Melo, Antonio Ferreira; Pimpao, Antonio B.; Pereira, Sofia Azeredo; Bissoli, Nazare Souza] Univ NOVA Lisboa, Fac Ciencias Med FCM, NOVA Med Sch NMS, iNOVA4Hlth, P-1159056 Lisbon, Portugal.
   [de Melo, Antonio Ferreira; Pimpao, Antonio B.; Pereira, Sofia Azeredo] Ctr Clin & Acad Lisboa, P-1156056 Lisbon, Portugal.
   [Escouto, Leonardo; Peixoto, Pollyana; Ronchi, Silas Nascimento; Bissoli, Nazare Souza] Univ Fed Espirito Santo, Dept Physiol Sci, Vitoria, ES, Brazil.
   [Brasil, Girlandia] Univ Vila Velha UVV, Dept Pharm, Vila Velha, Brazil.
C3 Universidade Nova de Lisboa; Universidade Federal do Espirito Santo;
   Centro Universitario Vila Velha
RP de Melo, AF Jr (corresponding author), Univ Nova Lisboa, Fac Ciencias Med FCM, NOVA Med Sch NMS, P-1159056 Lisbon, Portugal.
EM melo.junior@nms.unl.pt; antonio.pimpao@nms.unl.pt;
   sofia.pereira@nms.unl.pt
RI Peixoto, Pollyana/AAR-3079-2020; Bissoli, Nazare/ABA-2679-2021; Brasil,
   Girlandia/LXA-8523-2024; Ferreira de Melo Junior, Antonio/LIG-3474-2024;
   Pimpão, António/ABJ-6567-2022; de Azeredo Pereira, Sofia/M-2976-2019
OI Ferreira de Melo Junior, Antonio/0000-0001-6831-1823; de Azeredo
   Pereira, Sofia/0000-0002-8456-9995
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NR 158
TC 0
Z9 0
U1 2
U2 2
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0041-008X
EI 1096-0333
J9 TOXICOL APPL PHARM
JI Toxicol. Appl. Pharmacol.
PD FEB
PY 2025
VL 495
AR 117238
DI 10.1016/j.taap.2025.117238
EA JAN 2025
PG 14
WC Pharmacology & Pharmacy; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Toxicology
GA U1R3J
UT WOS:001409647000001
PM 39855308
OA hybrid
DA 2025-06-11
ER

PT J
AU Fullenkamp, AM
   Bell, LN
   Robbins, RD
   Lee, L
   Saxena, R
   Alloosh, M
   Klaunig, JE
   Mirmira, RG
   Sturek, M
   Chalasani, N
AF Fullenkamp, Allison M.
   Bell, Lauren N.
   Robbins, Reiesha D.
   Lee, Lydia
   Saxena, Romil
   Alloosh, Mouhamad
   Klaunig, James E.
   Mirmira, Raghavendra G.
   Sturek, Michael
   Chalasani, Naga
TI Effect of Different Obesogenic Diets on Pancreatic Histology in Ossabaw
   Miniature Swine
SO PANCREAS
LA English
DT Article
DE animal model; fatty pancreas; metabolic syndrome; fatty liver
ID BETA-CELL MASS; OXIDATIVE STRESS; METABOLIC SYNDROME; OBESITY; SEVERITY;
   MODEL; RATS
AB Objective: Obesity is a factor in the outcome and severity of pancreatic conditions. We examined the effect of hypercaloric diets on the pancreata of Ossabaw swine, a large animal model of metabolic syndrome and obesity.
   Methods: Swine were fed with 1 of 4 diets: high-fructose (n = 9), atherogenic (n = 10), modified atherogenic (n = 6), or eucaloric standard diet (n = 12) for 24 weeks. Serum chemistries were measured, and pancreata were examined for histological abnormalities including steatosis, inflammation or fibrosis, insulin content, and oxidative stress.
   Results: The fructose, atherogenic, and modified atherogenic diet groups exhibited obesity, metabolic syndrome, islet enlargement, and significantly increased pancreatic steatosis (22.9% +/- 7.5%, 19.7% +/- 7.7%, and 38.7% +/- 15.3% fat in total tissue area, respectively) compared with controls (9.3% +/- 1.9%; P < 0.05). The modified atherogenic diet group showed significantly increased oxidative stress levels as evidenced by elevated serum malondialdehyde (3.0 +/- 3.3 vs 1.5 +/- 0.3 mu mol/L in controls; P = 0.006) and pancreatic malondialdehyde (0.1 +/- 0.12 vs 0.04 +/- 0.01 nmol/mg protein in controls; P=0.01). None of the swine exhibited pancreatitis or cellular injury.
   Conclusions: Ossabaw swine fed with a modified atherogenic diet developed significant pancreatic steatosis and increased oxidative stress, but no other histological abnormalities were observed.
C1 [Fullenkamp, Allison M.; Bell, Lauren N.; Lee, Lydia; Chalasani, Naga] Indiana Univ Sch Med, Div Gastroenterol Hepatol, Indianapolis, IN 46202 USA.
   [Robbins, Reiesha D.] Univ Virginia, Dept Pharmacol, Charlottesville, VA 22908 USA.
   [Saxena, Romil] Indiana Univ Sch Med, Dept Pathol & Lab Med, Indianapolis, IN 46202 USA.
C3 Indiana University System; Indiana University Bloomington; University of
   Virginia; Indiana University System; Indiana University Bloomington
RP Chalasani, N (corresponding author), Indiana Univ Sch Med, Div Gastroenterol Hepatol, 1050 Wishard Blvd,RG4100, Indianapolis, IN 46202 USA.
EM nchalasa@iupui.edu
RI Klaunig, James/I-6177-2016; lee, lydia/HPD-2945-2023; Sturek,
   Michael/CAH-2948-2022; Mirmira, Raghavendra/AAD-7592-2020
OI Klaunig, James/0000-0002-4736-2223; Sturek, Michael/0000-0002-2920-7406
FU Public Health Service [RR-013223, HL-062552]; Purina TestDiet, Inc;
   Purdue-Indiana University;  [R01CA100908]
FX This study was supported by the Public Health Service Grants RR-013223
   and HL-062552 and Purina TestDiet, Inc to MS, R01CA100908 to JK, and the
   Purdue-Indiana University Comparative Medicine Program.
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NR 26
TC 22
Z9 25
U1 0
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0885-3177
EI 1536-4828
J9 PANCREAS
JI Pancreas
PD APR
PY 2011
VL 40
IS 3
BP 438
EP 443
DI 10.1097/MPA.0b013e3182061583
PG 6
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 736NL
UT WOS:000288501300017
PM 21240032
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Kang, MG
   Koh, SB
   Cha, BS
   Park, JK
   Woo, JM
   Chang, SJ
AF Kang, MG
   Koh, SB
   Cha, BS
   Park, JK
   Woo, JM
   Chang, SJ
TI Association between job stress on heart rate variability and metabolic
   syndrome in shipyard male workers
SO YONSEI MEDICAL JOURNAL
LA English
DT Article
DE stress; heart rate variability; metabolic syndrome
ID NERVOUS-SYSTEM; BLOOD-PRESSURE; DISEASE; RISK; STRAIN
AB A growing body of literature has documented that job stress is associated with the development of cardiovascular disease. Nevertheless, the pathophysiological mechanism of this association remains unclear. The purpose of this study is to elucidate the relationship between job stress, heart rate variability, and metabolic syndrome. The study design was cross-sectional, and a total of 169 industrial workers were recruited. A structured-questionnaire was used to assess the general characteristics and job characteristics (work demand, decision latitude). Heart rate variability (HRV) was recorded using SA-2000 (medi-core), and was assessed by time-domain and by frequency-domain analyses. Time domain analysis was performed using SDNN (Standard Deviation of normal to normal interval), and spectral analysis using low-frequency (LF), high-frequency (HF), and total frequency power. Metabolic syndrome was defined on the basis of risk factors being clustered when three or more of the following cardiovascular risk factors were included in the fifth quintile: glucose, systolic blood pressure, high-density lipoprotein cholesterol (bottom quintile), triglyceride, and waist-hip ratio. The results showed that job characteristics were not associated with cardiovascular risk factors. Compared to the lower strain group (low strain+passive+active group), the high strain group had a less favorable cardiovascular risk profile with higher levels of blood pressure, glucose, homocysteine, and clotting factor, but the difference was not statistically significant. The SDNN of HRV was significantly lower in the high strain group than in the low strain group. The prevalence of metabolic syndrome in the lower strain group and high strain group was 13.2% and 23.8%, respectively. In the high strain group, the metabolic syndrome was significantly related to a decreased SDNN. However, we could not find a significant association in LF/HF ratio. This result suggests that decreased HRV found in the high-strain group are not a direct indicator of disease. However, it can induce cardiovascular abnormalities or dysfunctions related to the onset of heart disease among high risk groups.
C1 Yonsei Univ, Wonju Coll Med, Dept Prevent Med, Wonju 220701, South Korea.
   Yonsei Univ, Wonju Coll Med, Inst Occupat Med, Wonju 220701, South Korea.
   Chosun Univ, Coll Med, Dept Prevent Med, Kwangju, South Korea.
   Inje Univ, Seoul Paik Hosp, Dept Neuropsychiat, Seoul, South Korea.
C3 Yonsei University; Yonsei University; Chosun University; Inje University
RP Yonsei Univ, Wonju Coll Med, Dept Prevent Med, Wonju 220701, South Korea.
EM kohhj@wonju.yonsei.ac.kr
RI Woo, Jong/D-2353-2014
OI Woo, Jongmin/0000-0003-1314-126X
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NR 35
TC 77
Z9 85
U1 0
U2 9
PU YONSEI UNIV COLL MEDICINE
PI SEOUL
PA 50-1 YONSEI-RO, SEODAEMUN-GU, SEOUL 120-752, SOUTH KOREA
SN 0513-5796
EI 1976-2437
J9 YONSEI MED J
JI Yonsei Med. J.
PD OCT 31
PY 2004
VL 45
IS 5
BP 838
EP 846
DI 10.3349/ymj.2004.45.5.838
PG 9
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 868FL
UT WOS:000224899400010
PM 15515194
OA gold
DA 2025-06-11
ER

PT J
AU Grassi, G
   Padmanabhan, S
   Menni, C
   Seravalle, G
   Lee, WK
   Bombelli, M
   Brambilla, G
   Giannattasio, C
   Cesana, G
   Dominiczak, A
   Mancia, G
AF Grassi, Guido
   Padmanabhan, Sandosh
   Menni, Cristina
   Seravalle, Gino
   Lee, Wai K.
   Bombelli, Michele
   Brambilla, Gianmaria
   Giannattasio, Cristina
   Cesana, Giancarlo
   Dominiczak, Anna
   Mancia, Giuseppe
TI Association between ADRA1A gene and the metabolic syndrome:
   candidate genes and functional counterpart in the PAMELA population
SO JOURNAL OF HYPERTENSION
LA English
DT Article
DE association; genetics; metabolic syndrome; microneurography; sympathetic
   nervous system
ID SYMPATHETIC NEURAL ACTIVATION; AMBULATORY BLOOD-PRESSURE; QUANTITATIVE
   TRAIT LOCI; WIDE LINKAGE SCAN; INSULIN-RESISTANCE; HYPERTENSION;
   GLUCOSE; DAMAGE; FALSE; RISK
AB Objectives There is currently uncertainty about whether metabolic syndrome has a common underlying process. We performed a gene-centric association study of metabolic syndrome in 98 major cardiometabolic genes in the large, well phenotyped Pressioni Arteriose Monitorate e Loro Associazioni (PAMELA) study. We followed this with functional studies to elucidate a possible mechanism for the top association signal.
   Methods From the PAMELA cohort, we sampled 1407 individuals with information on the metabolic syndrome (ATPIII criteria). We analyzed 1324 tagging single-nucleotide polymorphisms (SNPs) in 98 candidate genes selected, based on known pathways involved in sympathetic nervous system, oxidative stress, renin-angiotensin system and sodium balance.
   Results The SNP rs17055869 near the alpha-1A-adrenoreceptor gene (ADRA1A) showed the strongest association with metabolic syndrome (odds ratio 1.7, CI 1.3-2.2; P=0.00007, P=0.000098 after permutation). In order to determine a functional basis for this association, we examined in a subgroup of metabolic syndrome patients whether the allelic distribution of the above mentioned gene is different according to the different degree of the metabolic syndrome-related sympathetic activation, directly assessed by the gold standard method to assess neuroadrenergic drive, that is microneurographic recording of efferent postganglionic muscle sympathetic nerve traffic. All metabolic syndrome patients with a lesser degree of sympathetic activation were homozygous for the major allele (C), whereas those with a very pronounced sympathetic overdrive had an over-representation of the minor T allele (P<0.0001).
   Conclusion Thus, the rs17055869 SNP near the 3' end of ADRA1A is significantly associated with metabolic syndrome and it may be involved in determining a greater level of sympathetic activation in metabolic syndrome patients. J Hypertens 29: 1121-1127 (C) 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins.
C1 [Grassi, Guido; Menni, Cristina; Bombelli, Michele; Giannattasio, Cristina; Cesana, Giancarlo; Mancia, Giuseppe] Osped San Gerardo, Med Clin, Monza, Italy.
   [Grassi, Guido; Menni, Cristina; Bombelli, Michele; Giannattasio, Cristina; Cesana, Giancarlo; Mancia, Giuseppe] Univ Milano Bicocca, Dept Prevent & Clin Med, Milan, Italy.
   [Padmanabhan, Sandosh; Menni, Cristina; Lee, Wai K.; Dominiczak, Anna] Univ Glasgow, BHF Glasgow Cardiovasc Res Ctr, Glasgow, Lanark, Scotland.
   [Seravalle, Gino] Ist Auxol Italiano, Milan, Italy.
   [Brambilla, Gianmaria] Ist Sci Multimed, Milan, Italy.
C3 San Gerardo Hospital; University of Milano-Bicocca; University of
   Glasgow; IRCCS Istituto Auxologico Italiano
RP Grassi, G (corresponding author), Osped San Gerardo, Med Clin, Via Pergolesi 33, I-20052 Milan, Italy.
EM guido.grassi@unimib.it
RI MANCIA, GIUSEPPE/AGF-9410-2022; seravalle, gino/K-1442-2019; Dominiczak,
   Anna/P-9390-2017; Menni, Cristina/JLL-2864-2023
OI seravalle, gino/0000-0003-3638-8011; Padmanabhan,
   Sandosh/0000-0003-3869-5808; Lee, Wai Kwong/0000-0001-8560-8063;
   Dominiczak, Anna/0000-0003-4913-3608; Menni,
   Cristina/0000-0001-9790-0571
FU British Heart Foundation [BHFPG/02/128, FS/05/095/19937]; Wellcome Trust
   Cardiovascular Functional Genomics Initiative [066780/2/012]; European
   Union [LSHM-CT-2006-037093]; Cariplo Foundation, Italy
FX We thank Dr Stefano Signorini and the Laboratory at the Desio Hospital
   for sample storage and DNA extraction. Work in Glasgow is funded by the
   British Heart Foundation Chair and Programme Grant BHFPG/02/128 to A. F.
   D., the Wellcome Trust Cardiovascular Functional Genomics Initiative
   066780/2/012 to AFD and the European Union's Sixth Framework Programme
   InGenious HyperCare LSHM-CT-2006-037093 to A. F. D. and C. D. S. P. is
   supported by an Intermediate Research Fellowship by the British Heart
   Foundation (FS/05/095/19937). This project was also supported by the
   Cariplo Foundation, Italy.
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NR 41
TC 16
Z9 16
U1 0
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0263-6352
EI 1473-5598
J9 J HYPERTENS
JI J. Hypertens.
PD JUN
PY 2011
VL 29
IS 6
BP 1121
EP 1127
DI 10.1097/HJH.0b013e328346d72c
PG 7
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 759MY
UT WOS:000290251500015
PM 21519279
DA 2025-06-11
ER

PT J
AU Richter, K
   Baumgärtner, L
   Niklewski, G
   Peter, L
   Köck, M
   Kellner, S
   Hillemacher, T
   Buttner-Teleaga, A
AF Richter, Kneginja
   Baumgaertner, Lisa
   Niklewski, Guenter
   Peter, Lukas
   Koeck, Melanie
   Kellner, Stefanie
   Hillemacher, Thomas
   Buettner-Teleaga, Antje
TI Sleep disorders in migrants and refugees: a systematic review with
   implications for personalized medical approach
SO EPMA JOURNAL
LA English
DT Review
DE Sleep disorders; Sleep disturbances; Prediction; Prevention;
   Personalized approach; Insomnia; Migrants; Migrant workers; Refugees;
   Refugee children; Asylum seeker; Trauma; Sleep
ID MENTAL-HEALTH; DISTURBANCES; CHILDREN; US
AB Background Sleep disorders are very common in migrants and refugees, often as a comorbid disorder to different somatic or psychiatric diagnoses and psychological disturbances such as metabolic syndrome, post-traumatic stress disorder, depression, and anxiety disorders. Objectives To review published prevalence rates as well as possible predictors for sleep disturbances in these vulnerable groups, including pre-migration stress, acculturation, and trauma before, during, and after migration, integration, and lifestyle in the host country with implications for predictive, preventive, and personalized medical approach (3PM). Data sources Electronic databases PubMed, PsycInfo, and Web of Knowledge were searched using (combined) search terms "migrant," "asylum seeker," "refugee," "sleep disturbances," "sleep disorder," "insomnia," and "sleep wake disorder." Study eligibility criteria Peer-reviewed studies from 2000 to 2018 reporting data on prevalence and/or predictors of any measure of sleep disturbance were included. Participants Studies on international migrants and refugees, as well as internally displaced populations, were included. Methods We conducted a systematic review on the topic of sleep disorders in migrant and refugee populations. Only published articles and reviews in peer-reviewed journals were included. Results We analyzed five studies on sleep disorders in migrants, five studies on adult refugees, and three on refugee children and adolescents. Prevalence of sleep disorders in migrants and refugees ranges between 39 and 99%. In migrant workers, stress related to integration and adaptation to the host society is connected to higher risks of snoring, metabolic diseases, and insomnia. Sleep disturbances in refugees are predicted by past war experience. Sleep difficulties in adult and child refugees are strongly correlated to trauma. Torture of parents and grandparents can predict sleep disorders in refugee children, while being accompanied by parents to the host country has a protective effect on children's sleep. Conclusions and implications Considering the differences in risk factors, vulnerability, and traumatic life events for different migrant populations, origins of sleep difficulties vary, depending on the migrant populations. Effects on sleep disturbances and sleep quality may be a result of integration in the host country, including changes of lifestyle, such as diet and working hours with implication for OSAS (obstructive sleep apnea) and insomnia. Compared with migrant populations, sleep disturbances in refugee populations are more correlated with mental health symptoms and disorders, especially PTSD (post-traumatic stress disorder), than with psychosocial problems. In juvenile refugee populations, psychological problems and disturbed sleep are associated with traumatic experiences during their journey to the host country.
   Findings highlight the need for expert recommendations for development of 3P approach stratified in the following: (1) prediction, including structured exploration of predisposing and precipitating factors that may trigger acute insomnia, screening of the according sleep disorders by validated translated questionnaires and sleep diaries, and a face-to-face or virtual setting and screening of OSAS; (2) target prevention by sleep health education for female and male refugees and migrant workers, including shift workers; and (3) personalized medical approach, including translated cognitive behavioral treatment for insomnia (CBT-I) and imagery rehearsal therapy for refugees and telehealth programs for improved CPAP adherence in migrants, with the goal to enable better sleep health quality and improved health economy.
C1 [Richter, Kneginja; Baumgaertner, Lisa; Niklewski, Guenter; Peter, Lukas; Koeck, Melanie; Hillemacher, Thomas] Paracelsus Med Univ, Univ Clin Psychiat & Psychotherapy, Nurnberg, Germany.
   [Richter, Kneginja; Peter, Lukas; Kellner, Stefanie] Tech Univ Nuremberg Georg Simon Ohm, Fac Social Work, Nurnberg, Germany.
   [Richter, Kneginja; Niklewski, Guenter] Univ Goce Delcev, Fac Med Sci, Stip, North Macedonia.
   [Buettner-Teleaga, Antje] Woosuk Univ, Inst Cognit Sci, Wonju, South Korea.
   [Buettner-Teleaga, Antje] Univ Witten Herdecke, Dept Psychiat, Witten, Germany.
C3 Goce Delcev University of Stip; Woosuk University; Witten Herdecke
   University
RP Richter, K (corresponding author), Paracelsus Med Univ, Univ Clin Psychiat & Psychotherapy, Nurnberg, Germany.; Richter, K (corresponding author), Tech Univ Nuremberg Georg Simon Ohm, Fac Social Work, Nurnberg, Germany.; Richter, K (corresponding author), Univ Goce Delcev, Fac Med Sci, Stip, North Macedonia.
EM Kneginja.Richter@gmx.de
RI Kellner, Stefanie/JQI-2967-2023; Retzer, Lukas/AAC-2625-2021; Richter,
   Kneginja/N-3297-2017
OI Richter, Kneginja/0000-0003-0396-9530
CR [Anonymous], GESUNDHEITLICHE UNGL
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NR 27
TC 35
Z9 36
U1 4
U2 44
PU SPRINGER INT PUBL AG
PI CHAM
PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND
SN 1878-5077
EI 1878-5085
J9 EPMA J
JI EPMA J.
PD JUN
PY 2020
VL 11
IS 2
SI SI
BP 251
EP 260
DI 10.1007/s13167-020-00205-2
EA MAY 2020
PG 10
WC Medicine, General & Internal; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine; Research & Experimental Medicine
GA LU9AU
UT WOS:000532649400001
PM 32549917
OA Green Published
DA 2025-06-11
ER

PT J
AU Shoshany, O
   Katz, DJ
   Love, C
AF Shoshany, Ohad
   Katz, Darren J.
   Love, Christopher
TI Much more than prescribing a pill - Assessment and treatment of erectile
   dysfunction by the general practitioner
SO AUSTRALIAN FAMILY PHYSICIAN
LA English
DT Article
ID CARDIOVASCULAR-DISEASE; AUSTRALIAN MEN; SEXUAL HEALTH; RECOMMENDATIONS;
   EXPERIENCE
AB Background Erectile dysfunction is a common but often neglected condition. Prevalence increases with age, but is not insignificant in younger men.
   Objectives This article will broadly describe the epidemiology, classification and risk factors of erectile dysfunction. It will also discuss assessment and current treatment modalities, with a particular focus on the unique role of the general practitioner (GP).
   Discussion Erectile dysfunction may be classified as vasculogenic, neurogenic, endocrinological, drug-related, psychogenic or mixed. Commonly, erectile dysfunction is a cause of anxiety and even depression. Risk factors, such as smoking and hypertension, and reversible causes, such as hypogonadism or offending medications, should be addressed. At present, oral pharmacotherapy represents the first-line option for most patients with erectile dysfunction. It is of utmost importance to evaluate and treat comorbidities, such as depression, metabolic syndrome and cardiovascular disease, that often accompany erectile dysfunction. Patients will undoubtedly benefit from comprehensive management by a dedicated GP. Occasionally, referral to a urologist, psychologist or sexual health physician may be required.
C1 [Shoshany, Ohad; Katz, Darren J.; Love, Christopher] Mens Hlth Melbourne, Melbourne, Vic, Australia.
   [Shoshany, Ohad; Katz, Darren J.] Western Hlth, St Albans, Vic, Australia.
   [Love, Christopher] Urol South, Moorabbin, Vic, Australia.
   [Love, Christopher] Monash Med Ctr, Dept Urol, Clayton, Vic, Australia.
   [Love, Christopher] Bayside Urol, Melbourne, Vic, Australia.
C3 Monash University; Monash Health; Monash Medical Centre
RP Shoshany, O (corresponding author), Mens Hlth Melbourne, Melbourne, Vic, Australia.; Shoshany, O (corresponding author), Western Hlth, St Albans, Vic, Australia.
EM ohadsh10@gmail.com
RI Katz, Darren/KYO-9625-2024
OI Shoshany, Ohad/0000-0002-4211-6277; Katz, Darren/0000-0003-0861-5643
CR Althof SE, 2013, J SEX MED, V10, P26, DOI [10.1111/jsm.12141, 10.1111/j.1743-6109.2012.02823.x]
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NR 24
TC 6
Z9 6
U1 0
U2 2
PU ROYAL AUSTRALIAN COLLEGE GENERAL PRACTITIONERS
PI SOUTH MELBOURNE
PA 1 PALMERSTON CRESCENT, SOUTH MELBOURNE, VICTORIA 3205, AUSTRALIA
SN 0300-8495
J9 AUST FAM PHYSICIAN
JI Aust. Fam. Physician
PD SEP
PY 2017
VL 46
IS 9
BP 634
EP 639
PG 6
WC Primary Health Care; Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA FF5BE
UT WOS:000408985300005
PM 28892593
DA 2025-06-11
ER

PT J
AU Jin, HS
   Choi, EB
   Kim, M
   Oh, SS
   Jang, SI
AF Jin, Hyung-sub
   Choi, Eun-bee
   Kim, Minseo
   Oh, Sarah Soyeon
   Jang, Sung-In
TI Association between Use of Nutritional Labeling and the Metabolic
   Syndrome and Its Components
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Article
DE metabolic syndrome; nutritional labeling; Korea National Health and
   Nutritional Examination Survey; smoking; drinking; stress
ID KOREAN NATIONAL-HEALTH; ALCOHOL-CONSUMPTION; LOWER RISK; PREVALENCE;
   ADULTS; RESOURCE; MEN
AB In this study, we looked into the association between the diagnosis of metabolic syndrome (MetS) and nutritional label awareness. This study used data from the Korea National Health and Nutritional Examination Survey (KNHANES) for the years 2007 to 2015. The study population consisted of a total of 41,667 Koreans of which 11,401 (27.4%) were diagnosed with metabolic syndrome and 30,266 (72.6%) were not. Groups not using nutritional labeling had a 24% increase in odds risk (OR: 1.24, 95% CI 1.14-1.35) of MetS compared to groups using nutritional labeling. Use of nutritional labeling was associated with all components of MetS. Central obesity showed the highest increase in odds risk (OR: 1.23, 95% CI 1.13-1.35) and high blood pressure showed the lowest increase in odds risk (OR: 1.11, 95% CI 1.02-1.20). Subgroup analysis revealed that statistically significant factors were smoking status, drinking status and stress status. Groups that smoke, groups that do not drink and groups with high stress were more vulnerable to MetS when not using nutritional labeling. People not using food labels tends to develop metabolic syndromes more than people using foods labels. In the subgroup analysis, drinking status, smoking status and stress status were significant factors.
C1 [Jin, Hyung-sub; Choi, Eun-bee; Kim, Minseo] Yonsei Univ, Coll Med, Med Courses, Seoul 03722, South Korea.
   [Oh, Sarah Soyeon; Jang, Sung-In] Yonsei Univ, Inst Hlth Serv Res, Seoul 03722, South Korea.
   [Oh, Sarah Soyeon] Yonsei Univ, Grad Sch, Dept Publ Hlth, Seoul 03722, South Korea.
   [Jang, Sung-In] Yonsei Univ, Coll Med, Dept Prevent Med, Seoul 03722, South Korea.
C3 Yonsei University; Yonsei University Health System; Yonsei University;
   Yonsei University; Yonsei University; Yonsei University Health System
RP Jang, SI (corresponding author), Yonsei Univ, Inst Hlth Serv Res, Seoul 03722, South Korea.; Jang, SI (corresponding author), Yonsei Univ, Coll Med, Dept Prevent Med, Seoul 03722, South Korea.
EM jangsi@yuhs.ac
RI Kim, minseo/HHS-8532-2022
OI Oh, Sarah/0000-0001-5709-2311; Jang, Sung-in/0000-0002-0760-2878; Choi,
   Eunbee/0000-0003-1395-8624; Jin, HyungSub/0000-0002-5994-6605
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NR 21
TC 2
Z9 4
U1 0
U2 0
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-7827
EI 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD NOV
PY 2019
VL 16
IS 22
AR 4486
DI 10.3390/ijerph16224486
PG 16
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA JV0KZ
UT WOS:000502057400183
PM 31739478
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Kapfhammer, HP
AF Kapfhammer, Hans-Peter
TI ACUTE AND LONG-TERM MENTAL AND PHYSICAL SEQUELAE IN THE AFTERMATH OF
   TRAUMATIC EXPOSURE - SOME REMARKS ON "THE BODY KEEPS THE SCORE"
SO PSYCHIATRIA DANUBINA
LA English
DT Review
DE trauma exposure; posttraumatic stress disorder; somatic symptoms;
   functional bodily distress syndromes; physical comorbidity;
   pathophysiological pathways
ID POSTTRAUMATIC-STRESS-DISORDER; MEDICALLY UNEXPLAINED SYMPTOMS; ADVERSE
   CHILDHOOD EXPERIENCES; FUNCTIONAL SOMATIC SYNDROMES;
   CORONARY-HEART-DISEASE; EARLY-LIFE ADVERSITY; METABOLIC SYNDROME;
   CARDIOVASCULAR-DISEASE; PSYCHOLOGICAL TRAUMA; HEALTH CONSEQUENCES
AB Traumata, by definition, refer to exterior events that expose a person to experiences of overwhelming threat and catastrophe and elicit feelings of death anxiety, panic, horror, helplessness, loss of personal control, and intractability. Most affected persons respond with at least some distressing symptoms of trauma-related memory intrusions, autonomic hyperarousal, dissociation, and depression in the acute aftermath. Fortunately, the majority of traumatized individuals succeed in coping with this major stress quite well during the following weeks and months unless the process of recovery is hampered by additional adverse psychosocial circumstances, psychological disposition or biological vulnerability.
   In a subgroup of persons a transition to acute and posttraumatic stress disorder or other major psychiatric disorders, e.g. depressive, anxiety, substance-related disorders may be observed. Posttraumatic stress disorders very often run a chronic course of illness enduring for many years or even life-long. The typical course of illness in PTSD is characterized not only by major psychiatric comorbidities contributing to a dramatically reduced health-related quality of life, to many deficits of psychosocial adaptation and a heightened suicide risk. It is also associated with a lot of major somatic health problems both in acute and long-term stages.
   The main focus here is on this special dimension of physical comorbidities in posttraumatic disorders. Empirical evidence underscores that trauma exposure, and in particular PTSD is significantly associated with major physical health problems in addition to well-known PTSD-related psychological, behavioural, and psychosocial impairments. Both self-report-based and objective assessments emphasized significantly increased rates of somatoform/functional syndromes and physical comorbidities, premature all-cause and specific mortality rates, heightened medical utilization behaviours, major socioeconomic costs, and reduced health-related quality of life in the aftermath of trauma exposure and posttraumatic stress disorders, thus defining a major challenge to any medical care system. Complex psycho-behavioural-somatic and somato-psycho-behavioural models are needed to better understand both acute and long-term effects of a perpetuating stress system on physical health.
C1 [Kapfhammer, Hans-Peter] Med Univ Graz, Dept Psychiat & Psychotherapeut Med, Auenbruggerpl 31, A-8036 Graz, Austria.
C3 Medical University of Graz
RP Kapfhammer, HP (corresponding author), Med Univ Graz, Dept Psychiat & Psychotherapeut Med, Auenbruggerpl 31, A-8036 Graz, Austria.
EM Hans-peter.kapfhammer@klinikum-graz.at
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NR 107
TC 14
Z9 15
U1 2
U2 26
PU MEDICINSKA NAKLADA
PI ZAGREB
PA VLASKA 69, HR-10000 ZAGREB, CROATIA
SN 0353-5053
J9 PSYCHIAT DANUB
JI Psychiatr. Danub.
PY 2018
VL 30
IS 3
BP 254
EP 272
DI 10.24869/psyd.2018.254
PG 19
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA GV1AO
UT WOS:000445798700002
PM 30267517
OA Green Published
DA 2025-06-11
ER

PT J
AU Sabet, JA
   Ekman, MS
   Lundvall, AS
   Risérus, U
   Johansson, U
   Öström, Å
   Adamsson, V
   Cao, Y
   Msghina, M
   Brummer, RJ
AF Sabet, Julia A.
   Ekman, Moa S.
   Lundvall, A. Sofia
   Riserus, Ulf
   Johansson, Ulrica
   Ostrom, Asa
   Adamsson, Viola
   Cao, Yang
   Msghina, Mussie
   Brummer, Robert J.
TI Feasibility and Acceptability of a Healthy Nordic Diet Intervention for
   the Treatment of Depression: A Randomized Controlled Pilot Trial
SO NUTRIENTS
LA English
DT Article
DE depression; major depressive disorder; diet; nutrition; randomized
   controlled trial; randomized controlled pilot trial; healthy Nordic
   diet; mental health; palatability; food liking
ID METABOLIC SYNDROME; MAJOR DEPRESSION; PLACEBO-RESPONSE; RATING-SCALE;
   QUALITY; QUESTIONNAIRE; ASSOCIATIONS; METAANALYSIS; PERFORMANCE;
   IMPAIRMENT
AB Healthy diet interventions have been shown to improve depressive symptoms, but there is a need for randomized controlled trials (RCTs) that are double blind and investigate biological mechanisms. The primary objectives of this randomized controlled pilot trial were to test the palatability of the meals and the acceptability of the intervention in preparation for an 8-week RCT in the future, which will investigate whether a healthy Nordic diet improves depressive symptoms in individuals with major depressive disorder, and associated biological mechanisms. Depressed (n = 10) and non-depressed (n = 6) women and men were randomized to receive either a healthy Nordic diet (ND) or a control diet (CD) for 8 days. Participants were blinded to their diet allocation and the study hypotheses. Health questionnaires were completed before and after the intervention and, throughout the study, questionnaires assessed participants' liking for the meals, their sensory properties, adherence, and open-ended feedback. In the ND group, 75% of participants consumed only the provided foods, as instructed, compared to 50% of CD participants. The meals of both diets, on average, received good ratings for liking and sensory properties, though the ND ratings were somewhat higher. Overall, results were positive and informative, indicating that the planned RCT will be feasible and well-accepted, with some proposed modifications.
C1 [Sabet, Julia A.; Ekman, Moa S.; Lundvall, A. Sofia; Msghina, Mussie; Brummer, Robert J.] Orebro Univ, Fac Med & Hlth, Sch Med Sci, Sodra Grey Rosengatan 32, S-70362 Orebro, Sweden.
   [Ekman, Moa S.; Lundvall, A. Sofia; Ostrom, Asa] Orebro Univ, Sch Hospitality Culinary Arts & Meal Sci, S-71202 Grythyttan, Sweden.
   [Riserus, Ulf; Adamsson, Viola] Uppsala Univ, Dept Publ Hlth & Caring Sci, Clin Nutr & Metab, S-75122 Uppsala, Sweden.
   [Johansson, Ulrica] Umea Univ, Dept Clin Sci, Paediat, S-90185 Umea, Sweden.
   [Cao, Yang] Orebro Univ, Sch Med Sci, Clin Epidemiol & Biostat, S-70182 Orebro, Sweden.
   [Cao, Yang] Karolinska Inst, Inst Environm Med, Unit Integrat Epidemiol, S-17177 Stockholm, Sweden.
   [Msghina, Mussie] Karolinska Inst, Dept Clin Neurosci, S-17176 Stockholm, Sweden.
C3 Orebro University; Uppsala University; Umea University; Orebro
   University; Karolinska Institutet; Karolinska Institutet
RP Sabet, JA (corresponding author), Orebro Univ, Fac Med & Hlth, Sch Med Sci, Sodra Grey Rosengatan 32, S-70362 Orebro, Sweden.
EM julia.sabet@oru.se; moae28@hotmail.com; sofialundvall@hotmail.se;
   ulf.riserus@pubcare.uu.se; ulrica.johansson@umu.se; asa.ostrom@oru.se;
   viola.adamsson@hufb.se; yang.cao@oru.se; mussie.msghina@oru.se;
   robert.brummer@oru.se
RI Cao, Yang/C-6185-2008; Brummer, Robert/A-3137-2009
OI Sabet, Julia/0000-0002-7151-3642; Brummer, Robert/0000-0002-0362-0008;
   Cao, Yang/0000-0002-3552-9153; Johansson, Ulrica/0000-0002-0830-889X;
   Ostrom, Asa/0000-0001-8848-5812
FU Orebro University as part of its Food and Health strategic program
FX This study was funded by Orebro University as part of its Food and
   Health strategic program.
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NR 47
TC 5
Z9 5
U1 2
U2 14
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD MAR
PY 2021
VL 13
IS 3
AR 902
DI 10.3390/nu13030902
PG 17
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nutrition & Dietetics
GA RE1PT
UT WOS:000633936000001
PM 33802181
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Innes, JK
   Calder, PC
AF Innes, Jacqueline K.
   Calder, Philip C.
TI The Differential Effects of Eicosapentaenoic Acid and Docosahexaenoic
   Acid on Cardiometabolic Risk Factors: A Systematic Review
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE eicosapentaenoic acid; docosahexaenoic acid; omega-3 polyunsaturated
   fatty acids; cardiometabolic risk factor; systematic review
ID ALPHA-LINOLENIC ACID; POLYUNSATURATED FATTY-ACIDS;
   CARDIOVASCULAR-DISEASE RISK; CORONARY-HEART-DISEASE; LDL PARTICLE-SIZE;
   FISH-OIL; BLOOD-PRESSURE; OMEGA-3 INDEX; DENSITY-LIPOPROTEIN; VASCULAR
   FUNCTION
AB A large body of evidence supports the cardioprotective effects of the long-chain omega-3 polyunsaturated fatty acids (PUFAs), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA). There is increasing interest in the independent effects of EPA and DHA in the modulation of cardiometabolic risk factors. This systematic review aims to appraise the latest available evidence of the differential effects of EPA and DHA on such risk factors. A systematic literature review was conducted up to May 2017. Randomised controlled trials were included if they met strict eligibility criteria, including EPA or DHA > 2 g/day and purity 90%. Eighteen identified articles were included, corresponding to six unique studies involving 527 participants. Both EPA and DHA lowered triglyceride concentration, with DHA having a greater triglyceride-lowering effect. Whilst total cholesterol levels were largely unchanged by EPA and DHA, DHA increased high-density lipoprotein (HDL) cholesterol concentration, particularly HDL2, and increased low-density lipoprotein (LDL) cholesterol concentration and LDL particle size. Both EPA and DHA inhibited platelet activity, whilst DHA improved vascular function and lowered heart rate and blood pressure to a greater extent than EPA. The effects of EPA and DHA on inflammatory markers and glycaemic control were inconclusive; however both lowered oxidative stress. Thus, EPA and DHA appear to have differential effects on cardiometabolic risk factors, but these need to be confirmed by larger clinical studies.
C1 [Innes, Jacqueline K.; Calder, Philip C.] Univ Southampton, Fac Med, Human Dev & Hlth Acad Unit, Southampton SO16 6YD, Hants, England.
   [Calder, Philip C.] Univ Hosp Southampton NHS Fdn Trust, Natl Inst Hlth Res, Southampton Biomed Res Ctr, Southampton SO16 6YD, Hants, England.
   [Calder, Philip C.] Univ Southampton, Southampton SO16 6YD, Hants, England.
C3 University of Southampton; University of Southampton; University
   Hospital Southampton NHS Foundation Trust; University of Southampton
RP Calder, PC (corresponding author), Univ Southampton, Fac Med, Human Dev & Hlth Acad Unit, Southampton SO16 6YD, Hants, England.; Calder, PC (corresponding author), Univ Hosp Southampton NHS Fdn Trust, Natl Inst Hlth Res, Southampton Biomed Res Ctr, Southampton SO16 6YD, Hants, England.; Calder, PC (corresponding author), Univ Southampton, Southampton SO16 6YD, Hants, England.
EM innesjackie@gmail.com; pcc@soton.ac.uk
RI Calder, Philip/E-9739-2013
OI Calder, Philip/0000-0002-6038-710X
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NR 90
TC 150
Z9 162
U1 1
U2 30
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD FEB
PY 2018
VL 19
IS 2
AR 532
DI 10.3390/ijms19020532
PG 22
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA FZ3YN
UT WOS:000427527400216
PM 29425187
OA Green Published, Green Accepted, gold
DA 2025-06-11
ER

PT J
AU Barlow, CE
   Shuval, K
   Balasubramanian, BA
   Kendzor, DE
   Radford, NB
   DeFina, LF
   Gabriel, KP
AF Barlow, Carolyn E.
   Shuval, Kerem
   Balasubramanian, Bijal A.
   Kendzor, Darla E.
   Radford, Nina B.
   DeFina, Laura F.
   Gabriel, Kelley Pettee
TI Association Between Sitting Time and Cardiometabolic Risk Factors After
   Adjustment for Cardiorespiratory Fitness, Cooper Center Longitudinal
   Study, 2010-2013
SO PREVENTING CHRONIC DISEASE
LA English
DT Article
ID PHYSICAL-ACTIVITY; SEDENTARY BEHAVIOR; LIFE-STYLE; MEN; ADULTS; WOMEN;
   BIOMARKERS; PROTOCOLS; RESPONSES; OBESITY
AB Introduction
   Objective estimates, based on waist-worn accelerometers, indicate that adults spend over half their day (55%) in sedentary behaviors. Our study examined the association between sitting time and cardiometabolic risk factors after adjustment for cardiorespiratory fitness (CRF).
   Methods
   A cross-sectional analysis was conducted with 4,486 men and 1,845 women who reported daily estimated sitting time, had measures for adiposity, blood lipids, glucose, and blood pressure, and underwent maximal stress testing. We used a modeling strategy using logistic regression analysis to assess CRF as a potential effect modifier and to control for potential confounding effects of CRF.
   Results
   Men who sat almost all of the time (about 100%) were more likely to be obese whether defined by waist girth (OR, 2.61; 95% CI, 1.25-5.47) or percentage of body fat (OR, 3.33; 95% CI, 1.35-8.20) than were men who sat almost none of the time (about 0%). Sitting time was not significantly associated with other cardiometabolic risk factors after adjustment for CRF level. For women, no significant associations between sitting time and cardiometabolic risk factors were observed after adjustment for CRF and other covariates.
   Conclusion
   As health professionals struggle to find ways to combat obesity and its health effects, reducing sitting time can be an initial step in a total physical activity plan that includes strategies to reduce sedentary time through increases in physical activity among men. In addition, further research is needed to elucidate the relationships between sitting time and CRF for women as well as the underlying mechanisms involved in these relationships.
C1 [Barlow, Carolyn E.; DeFina, Laura F.] Cooper Inst, 12330 Preston Rd, Dallas, TX 75230 USA.
   [Barlow, Carolyn E.; Balasubramanian, Bijal A.] Univ Texas Hlth Sci Ctr Houston, Sch Publ Hlth, Dallas Campus, Dallas, TX USA.
   [Shuval, Kerem] Amer Canc Soc, Dept Intramural Res, Atlanta, GA 30329 USA.
   [Balasubramanian, Bijal A.] Univ Texas Southwestern Med Ctr Dallas, Harold C Simmons Canc Ctr, Dallas, TX 75390 USA.
   [Kendzor, Darla E.] Univ Oklahoma, Hlth Sci Ctr, Dept Family & Prevent Med, Oklahoma City, OK USA.
   [Kendzor, Darla E.] Stephenson Canc Ctr, Oklahoma Tobacco Res Ctr, Oklahoma City, OK USA.
   [Radford, Nina B.] Cooper Clin, Dallas, TX USA.
   [Gabriel, Kelley Pettee] Univ Texas Hlth Sci Ctr Houston, Sch Publ Hlth, Austin Campus, Austin, TX USA.
C3 Cooper Institute; University of Texas System; University of Texas Health
   Science Center Houston; American Cancer Society; University of Texas
   System; University of Texas Southwestern Medical Center Dallas;
   University of Oklahoma System; University of Oklahoma Health Sciences
   Center; University of Oklahoma System; University of Oklahoma Health
   Sciences Center; Cooper Institute; University of Texas System;
   University of Texas Health Science Center Houston
RP Barlow, CE (corresponding author), Cooper Inst, 12330 Preston Rd, Dallas, TX 75230 USA.
EM bwright@cooperinst.org
RI wright, beth/V-7496-2019
OI Balasubramanian, Bijal/0000-0003-2844-9048; Kendzor,
   Darla/0000-0002-7273-1916
FU American Cancer Society [MRSGT-10-104-01-CPHPS]
FX D.E.K. was supported, in part, by an American Cancer Society grant
   (MRSGT-10-104-01-CPHPS). We thank Kenneth H. Cooper, MD, MPH, for
   establishing the Cooper Center Longitudinal Study, the Cooper Clinic
   physicians and staff for collecting clinical data, and The Cooper
   Institute for maintaining the database.
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NR 28
TC 9
Z9 11
U1 1
U2 6
PU CENTERS  DISEASE CONTROL
PI ATLANTA
PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA
SN 1545-1151
J9 PREV CHRONIC DIS
JI Prev. Chronic Dis.
PD DEC
PY 2016
VL 13
AR E181
DI 10.5888/pcd13.160263
PG 12
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA EJ3KP
UT WOS:000393111400020
PM 28033088
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Gonzalez-Bulnes, A
   Astiz, S
   Ovilo, C
   Garcia-Contreras, C
   Vazquez-Gomez, M
AF Gonzalez-Bulnes, Antonio
   Astiz, Susana
   Ovilo, Cristina
   Garcia-Contreras, Consolacion
   Vazquez-Gomez, Marta
TI Nature and Nurture in the Early-Life Origins of Metabolic Syndrome
SO CURRENT PHARMACEUTICAL BIOTECHNOLOGY
LA English
DT Article
DE Developmental-programming; endocrine-disrupting-chemicals; epigenetics;
   lifestyle; metabolic-syndrome; nutrition; obesogenics;
   transgenerational-programming
ID INTRAUTERINE GROWTH RESTRICTION; DI(2-ETHYLHEXYL) PHTHALATE DEHP;
   ENDOCRINE-DISRUPTING COMPOUNDS; ACTIVATED-RECEPTOR-GAMMA;
   INSULIN-RESISTANCE; HIGH-ALTITUDE; BIRTH-WEIGHT; BISPHENOL-A; ADAPTIVE
   RESPONSES; DIABETES-MELLITUS
AB The combination of genetic background together with food excess and lack of exercise has become the cornerstone of metabolic disorders associated to lifestyle. The scenario is furthermore reinforced by their interaction with other environmental factors (stress, sleeping patterns, education, culture, rural versus urban locations, and xenobiotics, among others) inducing epigenetic changes in the exposed individuals. The immediate consequence is the development of further alterations like obesity and metabolic syndrome, and other adverse health conditions (type-2 diabetes, cardiovascular diseases, cancer, reproductive, immune and neurological disorders). Thus, having in mind the impact of the metabolic syndrome on the worldwide public health, the present review affords the relative roles and the interrelationships of nature (genetic predisposition to metabolic syndrome) and nurture (lifestyle and environmental effects causing epigenetic changes), on the establishment of the metabolic disorders in women; disorders that may evolve to metabolic syndrome prior or during pregnancy and may be transmitted to their descendants.
C1 [Gonzalez-Bulnes, Antonio; Astiz, Susana; Ovilo, Cristina; Garcia-Contreras, Consolacion; Vazquez-Gomez, Marta] INIA, Avda Puerta de Hierro S-N, Madrid 28040, Spain.
RP Gonzalez-Bulnes, A (corresponding author), INIA, Avda Puerta de Hierro S-N, Madrid 28040, Spain.
EM bulnes@inia.es
RI Gonzalez-Bulnes, Antonio/K-7691-2015; Astiz, Susana/AAN-8769-2021;
   Vazquez-Gomez, Marta/L-7054-2014; Ovilo, Cristina/N-9931-2014; GARCIA
   CONTRERAS, CONSOLACION/AAX-2057-2021
OI Vazquez-Gomez, Marta/0000-0002-8916-2086; Ovilo,
   Cristina/0000-0002-5738-8435; GARCIA CONTRERAS,
   CONSOLACION/0000-0003-4624-2585; Gonzalez-Bulnes,
   Antonio/0000-0002-0917-4475
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NR 158
TC 13
Z9 13
U1 0
U2 25
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1389-2010
EI 1873-4316
J9 CURR PHARM BIOTECHNO
JI Curr. Pharm. Biotechnol.
PY 2016
VL 17
IS 7
BP 573
EP 586
DI 10.2174/1389201017666160301103835
PG 14
WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
GA DN3FD
UT WOS:000376946900002
PM 26927212
DA 2025-06-11
ER

PT J
AU Johnson, M
   Day, M
   Moholkar, R
   Gilluley, P
   Goyder, E
AF Johnson, Maxine
   Day, Matthew
   Moholkar, Rajesh
   Gilluley, Paul
   Goyder, Elizabeth
TI Tackling obesity in mental health secure units: a mixed method synthesis
   of available evidence
SO BJPSYCH OPEN
LA English
DT Review
DE Forensic mental health services; primary care; patients
ID MAJOR DEPRESSIVE DISORDER; INTEGRATED WEIGHT MANAGEMENT; BIPOLAR
   DISORDER; PHYSICAL HEALTH; METABOLIC SYNDROME; SCHIZOPHRENIA; PEOPLE;
   INTERVENTIONS; RISK; METAANALYSIS
AB Background
   The prevalence and incidence of obesity are high in people with severe mental illness (SMI). In England, around 6000 people with SMI access care from secure mental health units. There is currently no specific guidance on how to reduce the risk of obesity-related morbidity and mortality in this population.
   Aims
   To identify international evidence that addresses the issue of obesity in mental health secure units.
   Method
   A mixed method review of evidence (published 2000-2015) was carried out to assess obesity prevalence, intervention and policy change, as well as barriers to change.
   Results
   Evidence from 22 mainly small, non-comparator studies (reported in 21 papers) using a range of methods was reviewed. Dietary, physical activity and cultural interventions being implemented within secure units to address the problem of obesity showed some promising outcomes for physical health and health education. These were facilitated by adequate organisational resources, staff training and motivated staff. Holistic interventions that included a social and/or competitive element were more likely to be taken up. Involving patients in decision-making mediated the tension between facilitating behaviour change and imposing control. Barriers to successful outcomes included patient movement in and out of units, severity of mental health condition and resistance to change by patients and staff.
   Conclusions
   Despite the promising outcomes reported, further assessment is needed of the feasibility, acceptability and effectiveness of interventions and policies targeting the obesogenic environment, using robust research methods. (c) The Royal College of Psychiatrists 2018.
C1 [Johnson, Maxine] Univ Sheffield, Sch Hlth & Related Res ScHARR, 30 Regent St, Sheffield S1 4DA, S Yorkshire, England.
   [Day, Matthew] Publ Hlth England, Publ Hlth Specialised Commissioning, London, England.
   [Moholkar, Rajesh] Reaside Clin, Birmingham, W Midlands, England.
   [Moholkar, Rajesh] Univ Birmingham, Sch Psychol, Birmingham, W Midlands, England.
   [Gilluley, Paul] East London NHS Fdn Trust, Forens Serv, London, England.
   [Goyder, Elizabeth] Univ Sheffield, Sch Hlth & Related Res ScHRR, Publ Hlth, Sheffield, S Yorkshire, England.
C3 University of Sheffield; Public Health England; University of
   Birmingham; University of Sheffield
RP Johnson, M (corresponding author), Univ Sheffield, Sch Hlth & Related Res ScHARR, 30 Regent St, Sheffield S1 4DA, S Yorkshire, England.
EM m.johnson@sheffield.ac.uk
RI Goyder, Elizabeth/A-2146-2010
OI Goyder, Elizabeth/0000-0003-3691-1888
FU Medical Research Council (MRC)
FX The project was funded by a 'Pathway to Discovery' award from the
   Medical Research Council (MRC) to E.G. and M.J. The views expressed are
   those of the authors and do not necessarily reflect the views of the
   MRC, Public Health England or NHS England.
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NR 51
TC 20
Z9 21
U1 0
U2 4
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 2056-4724
J9 BJPSYCH OPEN
JI BJPsych Open
PD JUL
PY 2018
VL 4
IS 4
BP 294
EP 301
DI 10.1192/bjo.2018.26
PG 8
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychiatry
GA HB9BV
UT WOS:000451387300011
PM 30083382
OA Green Published, Green Accepted, gold
DA 2025-06-11
ER

PT J
AU Stuebe, AM
AF Stuebe, Alison M.
TI Does breastfeeding prevent the metabolic syndrome, or does the metabolic
   syndrome prevent breastfeeding?
SO SEMINARS IN PERINATOLOGY
LA English
DT Review
DE Breastfeeding; Diabetes; Obesity; Metabolic syndrome
ID ADRENAL AXIS RESPONSES; BODY-MASS INDEX; GLUCOSE-TOLERANCE;
   DIABETES-MELLITUS; WEIGHT RETENTION; DELAYED-ONSET; RISK-FACTORS; OBESE
   WOMEN; LACTATION; DURATION
AB In mammalian physiology, lactation follows pregnancy. Disruption of this physiology is associated with long-term adverse maternal health outcomes, including higher risks of later-life obesity, type 2 diabetes, metabolic syndrome, hypertension, and cardiovascular disease. Multiple mechanisms likely contribute to these associations, including the metabolic demands of breastfeeding, modulation of stress reactivity, and confounding by other health behaviors. At the same time, evidence suggests that maternal metabolic health entering pregnancy affects lactation performance. In this paradigm, adverse lactation outcomes may be a marker for underlying maternal disease risk. Understanding these relationships has important clinical and policy implications for women's health. (C) 2015 Elsevier Inc. All rights reserved.
C1 [Stuebe, Alison M.] Univ N Carolina, Dept Obstet & Gynecol, Div Maternal Fetal Med, Sch Med, Chapel Hill, NC 27599 USA.
   [Stuebe, Alison M.] UNC Gillings Sch Global Publ Hlth, Dept Maternal & Child Hlth, Chapel Hill, NC USA.
C3 University of North Carolina School of Medicine; University of North
   Carolina; University of North Carolina Chapel Hill; University of North
   Carolina; University of North Carolina Chapel Hill
RP Stuebe, AM (corresponding author), Univ N Carolina, Dept Obstet & Gynecol, Div Maternal Fetal Med, Sch Med, 3010 Old Clin Bldg,CB 7516, Chapel Hill, NC 27599 USA.
EM astuebe@med.unc.edu
FU  [R01HL109216-01A1];  [R01 HD073220-01];  [R21DK092750-01]
FX Supported in part by R01HL109216-01A1, R01 HD073220-01, and
   R21DK092750-01.
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NR 58
TC 49
Z9 54
U1 0
U2 21
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0146-0005
EI 1558-075X
J9 SEMIN PERINATOL
JI Semin. Perinatol.
PD JUN
PY 2015
VL 39
IS 4
BP 290
EP 295
DI 10.1053/j.semperi.2015.05.008
PG 6
WC Obstetrics & Gynecology; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology; Pediatrics
GA CP4XD
UT WOS:000359885000008
PM 26187772
OA Green Accepted, Green Submitted
DA 2025-06-11
ER

PT J
AU Tian, XY
   Cioccoloni, G
   Sier, JH
   Naseem, KM
   Thorne, JL
   Moore, JB
AF Tian, Xiaoying
   Cioccoloni, Giorgia
   Sier, Joanna H.
   Naseem, Khalid M.
   Thorne, James L.
   Moore, J. Bernadette
TI Ergothioneine supplementation in people with metabolic syndrome (ErgMS):
   protocol for a randomised, double-blind, placebo-controlled pilot study
SO PILOT AND FEASIBILITY STUDIES
LA English
DT Article
DE Ergothioneine; Metabolic syndrome; Supplementation; Metabolome;
   Oxidative stress; Inflammation; ALT
ID OXIDATIVE STRESS; TRANSPORTER; KNOCKOUT; METAANALYSIS; MORTALITY;
   DISEASE; RISK
AB Background: Ergothioneine is a naturally occurring metabolite of histidine found in many foods and in high amounts in mushrooms. In vivo, ergothioneine acts as an antioxidant and is widely distributed in most mammalian tissues. While ergothioneine is sold as a dietary supplement for its antioxidant and anti-inflammatory properties, to date there are no published intervention trials examining its health benefits in humans. The aim of this work was to develop a study protocol for a pilot interventional trial that will establish the primary and secondary outcomes, and the power required, for a definitive randomised controlled trial to test the hypothesis that ergothioneine supplementation is beneficial for people with metabolic syndrome.
   Methods: We have designed the ErgMS study as a single-centre, randomised, double-blind, placebo-controlled, 3-arm parallel, pilot intervention trial, which aims to supplement participants with either placebo, 5 or 30 mg/day ergothioneine for 12 weeks. Measurements of metabolic syndrome risk factors, serum markers of oxidative stress (lipid peroxidation), inflammation, blood platelet function and liver function will take place at baseline, and after 6 weeks and 12 weeks of supplementation. In addition, we will examine if there are any changes in the serum metabolome in response to ergothioneine supplementation. Linear regression and two-way ANOVA will be utilised to analyse the association between ergothioneine and measured variables.
   Discussion: The ErgMS study will be the first study to address the question does ergothioneine supplementation have health benefits for people with metabolic syndrome. Study results will provide preliminary data as to which dose may improve inflammatory markers in adults with metabolic syndrome and will inform dose and primary outcome selection for a definitive randomised controlled trial.
C1 [Tian, Xiaoying; Cioccoloni, Giorgia; Sier, Joanna H.; Thorne, James L.; Moore, J. Bernadette] Univ Leeds, Sch Food Sci & Nutr, Leeds LS2 9JT, W Yorkshire, England.
   [Naseem, Khalid M.] Univ Leeds, Leeds Inst Cardiovasc & Metab Med, Leeds LS2 9JT, W Yorkshire, England.
C3 University of Leeds; University of Leeds
RP Moore, JB (corresponding author), Univ Leeds, Sch Food Sci & Nutr, Leeds LS2 9JT, W Yorkshire, England.
EM J.B.Moore@leeds.ac.uk
RI Moore, J/D-5258-2012; thorne, james/R-9878-2019
OI Moore, J Bernadette/0000-0003-4750-1550; Tian,
   Xiaoying/0000-0003-4641-4332; Cioccoloni, Giorgia/0000-0003-0102-9182
FU School of Food Science and Nutrition, University of Leeds; Tetrahedron
   (Paris, France)
FX The ErgMS study is funded by the School of Food Science and Nutrition,
   University of Leeds and Tetrahedron (Paris, France) who will
   manufacture, pack and provide both the placebo and ergothioneine
   capsules. Tetrahedron has had no role in the study design, will have no
   role in the conduct of this study and will not influence data
   collection, data management, data analysis and dissemination.
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NR 42
TC 7
Z9 7
U1 3
U2 19
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 2055-5784
J9 PILOT FEASIBILITY ST
JI Pilot Feasibility Stud.
PD OCT 29
PY 2021
VL 7
IS 1
AR 193
DI 10.1186/s40814-021-00929-6
PG 12
WC Medicine, Research & Experimental
WE Emerging Sources Citation Index (ESCI)
SC Research & Experimental Medicine
GA WP0KW
UT WOS:000712832500001
PM 34715934
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Cuturic, M
   Abramson, RK
   Breen, RJ
   Edwards, AC
   Levy, EE
AF Cuturic, Miroslav
   Abramson, Ruth K.
   Breen, Robert J.
   Edwards, Alfred C.
   Levy, Elliott E.
TI Comparison of serum carnitine levels and clinical correlates between
   outpatients and acutely hospitalised individuals with bipolar disorder
   and schizophrenia: A cross-sectional study
SO WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
LA English
DT Article
DE Carnitine; schizophrenia; bipolar disorder; metabolic syndrome;
   hospitalisation
ID ACETYL-L-CARNITINE; VALPROIC ACID THERAPY; MITOCHONDRIAL DYSFUNCTION;
   PSYCHIATRIC-PATIENTS; OXIDATIVE STRESS; DEFICIENCY; TRANSPORT;
   PHARMACOKINETICS; PATHOPHYSIOLOGY; ENCEPHALOPATHY
AB Objectives: We sought to compare serum carnitine levels and clinical correlates between stable outpatients and acutely hospitalised individuals with diagnoses of bipolar disorder and schizophrenia.Methods: We obtained clinical information as well as serum levels for total and free carnitine, high-density lipoprotein (HDL) and triglycerides in 60 consenting individuals.Results: We found higher total serum carnitine levels in our outpatient group in comparison to acutely hospitalised psychiatric patients, with a statistically significant P value of 0.045. Metabolic syndrome was more prevalent in the outpatient (37.9%) versus inpatient group (16.1%). We identified significantly higher carnitine levels in patients who met the criteria for metabolic syndrome in comparison to the patients without metabolic syndrome, with respective P values for total and free carnitine of 0.0048 and 0.0029.Conclusions: This study revealed a complex relationship among carnitine metabolism, metabolic syndrome and behavioural outcomes. Future studies of carnitine metabolism in the context of mental illness as well as metabolic syndrome are warranted.
C1 [Cuturic, Miroslav; Breen, Robert J.] Univ South Carolina, Sch Med, Dept Mental Hlth, Columbia, SC USA.
   [Cuturic, Miroslav] Univ South Carolina, Sch Med, Dept Neurol, Columbia, SC USA.
   [Abramson, Ruth K.; Breen, Robert J.] Univ South Carolina, Sch Med, Dept Neuropsychiat & Behav Sci, Columbia, SC USA.
   [Edwards, Alfred C.] Dept Mental Hlth, Greenville, SC USA.
   [Levy, Elliott E.] Med Univ South Carolina, Dept Mental Hlth, Charleston, SC 29425 USA.
   [Levy, Elliott E.] Med Univ South Carolina, Dept Psychiat & Behav Sci, Charleston, SC 29425 USA.
C3 University of South Carolina System; University of South Carolina
   Columbia; University of South Carolina System; University of South
   Carolina Columbia; University of South Carolina System; University of
   South Carolina Columbia; Medical University of South Carolina; Medical
   University of South Carolina
RP Cuturic, M (corresponding author), South Carolina Dept Mental Hlth, DIS Specialty Clin, 8301 Farrow Rd, Columbia, SC 29203 USA.
EM miroslav.cuturic@scdmh.org
FU Ensor Trust Mental Health Research Grant
FX This study was supported by the Ensor Trust Mental Health Research
   Grant.
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NR 30
TC 13
Z9 13
U1 2
U2 9
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1562-2975
EI 1814-1412
J9 WORLD J BIOL PSYCHIA
JI World J. Biol. Psychiatry
PD SEP
PY 2016
VL 17
IS 6
BP 475
EP 479
DI 10.1080/15622975.2016.1178803
PG 5
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychiatry
GA DW1MT
UT WOS:000383408000008
PM 27088656
DA 2025-06-11
ER

PT J
AU Ye, ZT
   Li, YL
   Yang, XL
   Li, CL
   Yu, R
   Zheng, GJ
   Su, ZQ
AF Ye, Zeting
   Li, Yanlin
   Yang, Xiaolin
   Li, Chenglin
   Yu, Rui
   Zheng, Guangjuan
   Su, Zuqing
TI Targeting Regulation of Macrophage to Treat Metabolic Disease: Role of
   Phytochemicals
SO CELL PROLIFERATION
LA English
DT Review; Early Access
DE macrophage; metabolic syndrome; metaflammation; phytotherapy
ID NF-KAPPA-B; FATTY-ACID OXIDATION; PROMOTING CHOLESTEROL EFFLUX;
   NECROSIS-FACTOR-ALPHA; INSULIN-RESISTANCE; LIPID-ACCUMULATION;
   GINSENOSIDE RB2; INDUCED INFLAMMATION; HEPATIC STEATOSIS; SIGNALING
   PATHWAY
AB Metabolic syndrome encompasses a cluster of predictive metabolic risk factors, including obesity, insulin resistance, dyslipidemia, hyperglycemia and hypertension. It is strongly associated with the development of type 2 diabetes and cardiovascular disease. Given the increasing morbidity and mortality associated with metabolic syndrome, along with the limited availability of drug treatments, it is high time to investigate the pathogenesis of this condition and explore potential pharmacotherapies. Macrophages, well-known innate immune cells, play an essential role in maintaining tissue immune homeostasis and multiple physiological processes, including glucose and lipid metabolism, oxidative stress and inflammation. Emerging evidence indicates that the effects of macrophages in metabolic syndrome are linked to macrophage-mediated metaflammation. Phytochemicals derived from natural plants have been shown to exert therapeutic effects on metabolic syndrome by modulating macrophage function. In this review, we sort out the role of macrophage-mediated metaflammation in the pathogenesis of metabolic syndrome and summarise potential phytochemicals that target macrophages for the treatment of this condition.
C1 [Ye, Zeting; Li, Yanlin; Yang, Xiaolin; Li, Chenglin; Yu, Rui; Su, Zuqing] Guangzhou Univ Chinese Med, Affiliated Hosp 2, State Key Lab Tradit Chinese Med Syndrome, Guangzhou, Peoples R China.
   [Ye, Zeting; Li, Yanlin; Yang, Xiaolin; Li, Chenglin; Yu, Rui; Zheng, Guangjuan; Su, Zuqing] Guangzhou Univ Chinese Med, Clin Coll 2, Guangdong Prov Key Lab Chinese Med Prevent & Treat, Guangzhou, Peoples R China.
   [Ye, Zeting; Li, Yanlin; Yang, Xiaolin; Li, Chenglin; Yu, Rui; Zheng, Guangjuan; Su, Zuqing] Guangzhou Univ Chinese Med, Clin Coll 2, Guangdong Hong Kong Macau Joint Lab Chinese Med &, Guangzhou, Peoples R China.
   [Zheng, Guangjuan] Guangzhou Univ Chinese Med, Affiliated Hosp 2, State Key Lab Dampness Syndrome Chinese Med, Guangzhou, Peoples R China.
C3 Guangzhou University of Chinese Medicine; Guangzhou University of
   Chinese Medicine; Guangzhou University of Chinese Medicine; Guangzhou
   University of Chinese Medicine
RP Su, ZQ (corresponding author), Guangzhou Univ Chinese Med, Affiliated Hosp 2, State Key Lab Tradit Chinese Med Syndrome, Guangzhou, Peoples R China.; Zheng, GJ; Su, ZQ (corresponding author), Guangzhou Univ Chinese Med, Clin Coll 2, Guangdong Prov Key Lab Chinese Med Prevent & Treat, Guangzhou, Peoples R China.; Zheng, GJ; Su, ZQ (corresponding author), Guangzhou Univ Chinese Med, Clin Coll 2, Guangdong Hong Kong Macau Joint Lab Chinese Med &, Guangzhou, Peoples R China.; Zheng, GJ (corresponding author), Guangzhou Univ Chinese Med, Affiliated Hosp 2, State Key Lab Dampness Syndrome Chinese Med, Guangzhou, Peoples R China.
EM zhengguangjuan@gzucm.edu.cn; suzq@gzucm.edu.cn
RI Zheng, Guangjuan/ABB-6496-2020
FU State Key Laboratory of Traditional Chinese Medicine Syndrome, The
   Second Affiliated Hospital of Guangzhou University of Chinese Medicine
   [QZ2023ZZ39]; Research Fund for Zhaoyang Talents of Guangdong Provincial
   Hospital of Chinese Medicine [ZY2022KY12, 2022KT1076]; Specific Fund of
   State Key Laboratory of Dampness Syndrome of Chinese Medicine
   [SZ2021ZZ20]; The 2020 Guangdong Provincial Science and Technology
   Innovation Strategy Special Fund (Guangdong-Hong Kong-Macau Joint Lab)
   [2020B1212030006]; Guangdong Provincial Key Laboratory of Chinese
   Medicine for Prevention and Treatment of Refractory Chronic Diseases
   [2023KT15523, YN2023MB11]; National Natural Science Foundation of
   Guangdong Provincial [2024A1515010568]; Chinese Medicine Scientific
   Research and Technology Research Projects of Guangdong Provincial
   Hospital of Chinese Medicine [YN2024GZRPY073, YN2024GZRPY069,
   YN2024GZRPY081]
FX This work was supported by grants from the State Key Laboratory of
   Traditional Chinese Medicine Syndrome, The Second Affiliated Hospital of
   Guangzhou University of Chinese Medicine (No. QZ2023ZZ39), the Research
   Fund for Zhaoyang Talents of Guangdong Provincial Hospital of Chinese
   Medicine (No. ZY2022KY12 and 2022KT1076), the Specific Fund of State Key
   Laboratory of Dampness Syndrome of Chinese Medicine under Grant (No.
   SZ2021ZZ20), the 2020 Guangdong Provincial Science and Technology
   Innovation Strategy Special Fund (Guangdong-Hong Kong-Macau Joint Lab)
   (No. 2020B1212030006), the Guangdong Provincial Key Laboratory of
   Chinese Medicine for Prevention and Treatment of Refractory Chronic
   Diseases (No. 2023KT15523 and YN2023MB11), National Natural Science
   Foundation of Guangdong Provincial (No. 2024A1515010568), and the
   Chinese Medicine Scientific Research and Technology Research Projects of
   Guangdong Provincial Hospital of Chinese Medicine (No. YN2024GZRPY073,
   YN2024GZRPY069, and YN2024GZRPY081).
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NR 269
TC 0
Z9 0
U1 4
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0960-7722
EI 1365-2184
J9 CELL PROLIFERAT
JI Cell Prolif.
PD 2025 MAR 5
PY 2025
DI 10.1111/cpr.70012
EA MAR 2025
PG 29
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA 1KY6A
UT WOS:001467494400001
PM 40045164
OA gold
DA 2025-06-11
ER

PT J
AU Inoue, N
AF Inoue, Nobutaka
TI Stress and Atherosclerotic Cardiovascular Disease
SO JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
LA English
DT Review
DE Depression; Atherosclerosis; NAPDH oxidase
ID ACUTE MYOCARDIAL-INFARCTION; CORONARY-HEART-DISEASE; NEUROTROPHIC
   FACTOR; OXIDATIVE STRESS; DEPRESSIVE SYMPTOMS; METABOLIC SYNDROME; MAJOR
   DEPRESSION; NADPH OXIDASE; MORTALITY; EVENTS
AB Recent major advances in medical science have introduced a wide variety of treatments against atherosclerosis-based cardiovascular diseases, which has led to a significant reduction in mortality associated with these diseases. However, atherosclerosis-based cardiovascular disease remains a leading cause of death. Furthermore, progress in medical science has demonstrated the pathogenesis of cardiovascular disease to be complicated, with a wide variety of underlying factors. Among these factors, stress is thought to be pivotal. Several types of stress are involved in the development of cardiovascular disease, including oxidative stress, mental stress, hemodynamic stress and social stress. Accumulating evidence indicates that traditional risk factors for atherosclerosis, including diabetes, hyperlipidemia, hypertension and smoking, induce oxidative stress in the vasculature. Oxidative stress is implicated in the pathogenesis of endothelial dysfunction, atherogenesis, hypertension and remodeling of blood vessels. Meanwhile, mental stress is a well-known major contributor to the development of cardiovascular disease. The cardiovascular system is constantly exposed to hemodynamic stress by the blood flow and/or pulsation, and hemodynamic stress exerts profound effects on the biology of vascular cells and cardiomyocytes. In addition, social stress, such as that due to a lack of social support, poverty or living alone, has a negative impact on the incidence of cardiovascular disease. Furthermore, there are interactions between mental, oxidative and hemodynamic stress. The production of reactive oxygen species is increased under high levels of mental stress in close association with oxidative stress. These stress responses and their interactions play central roles in the pathogenesis of atherosclerosis-based cardiovascular disease. Accordingly, the pathophysiological and clinical implications of stress are discussed in this article.
C1 [Inoue, Nobutaka] Kobe Rosai Hosp, Dept Cardiovasc Med, Kobe, Hyogo 6510053, Japan.
RP Inoue, N (corresponding author), Kobe Rosai Hosp, Dept Cardiovasc Med, Chuo Ku, 4-1-23 Kagoike Touri, Kobe, Hyogo 6510053, Japan.
EM nobutaka@kobeh.rofuku.go.jp
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NR 52
TC 46
Z9 53
U1 0
U2 19
PU JAPAN ATHEROSCLEROSIS SOC
PI TOKYO
PA NICHINAI-KAIKAN B1, 3-28-8 HONGO BUNKYO-KU, TOKYO, 113-0033, JAPAN
SN 1340-3478
EI 1880-3873
J9 J ATHEROSCLER THROMB
JI J. Atheroscler. Thromb.
PY 2014
VL 21
IS 5
BP 391
EP 401
DI 10.5551/jat.21709
PG 11
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA AP4SY
UT WOS:000342070300004
PM 24561512
OA hybrid
DA 2025-06-11
ER

PT J
AU Brown, T
   McKenna, B
   Furness, T
AF Brown, Trudy
   McKenna, Brian
   Furness, Trentham
TI Impact of a nurse practitioner role on metabolic monitoring completion
   and referrals for consumers admitted to the intensive care area of an
   acute inpatient psychiatric unit
SO INTERNATIONAL JOURNAL OF MENTAL HEALTH NURSING
LA English
DT Article
DE inpatient; mental health; metabolic syndrome; nurse practitioner
ID MENTAL-HEALTH-CONSUMERS; SCHIZOPHRENIA; INTERVENTION; METAANALYSIS;
   PREVALENCE; RISK; MORTALITY; ILLNESS; PEOPLE; TRIAL
AB Mental illness increases a person's risk of physical health issues, including cardiovascular disease, leading to premature morbidity and mortality. Screening for cardiovascular disease through metabolic monitoring is recommended to aid in early detection. The aim of the present study was to ascertain whether consumers admitted to an inpatient mental health unit receive routine metabolic monitoring, and to explore the contribution of a nurse practitioner to metabolic monitoring and the actioning of abnormal results. The present study used a retrospective mirror image cohort method to look at clinical consumer files for two separate 6-month periods before and after a nurse practitioner role commenced. Metabolic monitoring variables were computed as completion frequencies and percentages. Univariate analyses were computed to describe differences among metabolic monitoring variables. A total of 497 consumers were admitted to the mental health inpatient unit's intensive care area across the two 6-month data-collection periods. Prior to the nurse practitioner role, only 2% of consumers had their body mass index (BMI) risk calculated; less than 1% had their waist circumference measured, and no abnormal results were referred to a general practitioner (GP). After the nurse practitioner role commenced, BMI risk was calculated for 67% of consumers, waist circumference recorded for 68%, and referrals for abnormal results were forwarded to 37 consumers' GPs. A nurse practitioner on the inpatient mental health unit has allowed for a considerable increase in the metabolic screening of admitted consumers resulting in a number of referrals being forwarded to consumers' GPs to be acted upon.
C1 [Brown, Trudy] Northern Hosp, Northern Area Mental Hlth Serv, Epping, NSW, Australia.
   [Brown, Trudy; Furness, Trentham] Royal Melbourne Hosp, NorthWestern Mental Hlth, Melbourne, Vic, Australia.
   [McKenna, Brian] Auckland Univ Technol, Sch Clin Sci, Auckland, New Zealand.
   [McKenna, Brian] Auckland Reg Forens Psychiat Serv, Auckland, New Zealand.
   [Furness, Trentham] Australian Catholic Univ, Sch Nursing Midwifery & Paramed, Melbourne, Vic, Australia.
C3 Melbourne Health; Royal Melbourne Hospital; Auckland University of
   Technology; Australian Catholic University
RP Brown, T (corresponding author), Northern Hosp, Northern Psychiat Unit, 185 Cooper St, Epping, Vic 3076, Australia.
EM Trudy.brown@mh.org.au
RI Furness, Trentham/N-8563-2016
OI Furness, Trentham/0000-0002-3526-1687; Brown, Trudy/0000-0003-2255-5579
FU government's Victorian Nurse Practitioner Project
FX The authors acknowledge the government's Victorian Nurse Practitioner
   Project support for both project and publication grant. The authors
   would like to thank Ms Teresa Kelly and Dr Kurt Wendelborn (both from
   Northern Area Mental Health Service, The Northern Hospital, and
   NorthWestern Mental Health, The Royal Melbourne Hospital, Melbourne,
   Victoria, Australia) for their support of this project, and the
   consumers admitted to the inpatient unit between the noted periods who
   participated in the metabolic monitoring.
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NR 34
TC 13
Z9 13
U1 0
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1445-8330
EI 1447-0349
J9 INT J MENT HEALTH NU
JI Int. J. Ment. Health Nurs.
PD FEB
PY 2018
VL 27
IS 1
BP 341
EP 348
DI 10.1111/inm.12327
PG 8
WC Nursing; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Psychiatry
GA FS3XF
UT WOS:000419717100034
PM 28299868
DA 2025-06-11
ER

PT J
AU Salaramoli, S
   Mehri, S
   Yarmohammadi, F
   Hashemy, SI
   Hosseinzadeh, H
AF Salaramoli, Sanaz
   Mehri, Soghra
   Yarmohammadi, Fatemeh
   Hashemy, Seyed Isaac
   Hosseinzadeh, Hossein
TI The effects of ginger and its constituents in the prevention of
   metabolic syndrome: A review
SO IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
LA English
DT Review
DE Diabetes; Dyslipidemia; Ginger; Hypertension; Metabolic syndrome;
   Obesity; Zingiber
ID ZINGIBER-OFFICINALE-ROSCOE; HIGH-FAT DIET; PEPTIDE-1 RECEPTOR AGONISTS;
   INDUCED OXIDATIVE STRESS; INSULIN-RESISTANCE; CARDIOVASCULAR-DISEASE;
   OBESITY MANAGEMENT; ETHANOL EXTRACT; ESSENTIAL OILS; DIABETIC-RATS
AB Metabolic syndrome is a multifactorial disorder characterized by hyperglycemia, hyperlipidemia, obesity, and hypertension risk factors. Moreover, metabolic syndrome is the most ordinary risk factor for cardiovascular disease (CVD). Numerous chemical drugs are being synthesized to heal metabolic risk factors. Still, due to their abundant side effects, herbal medicines have a vital role in the treatment of these abnormalities. Ginger (Zingiber officinale Roscoe, Zingiberaceae) plant has been traditionally used in medicine to treat disorders, including CVD. The unique ginger properties are attributed to the presence of [6]-gingerol, [8]-gingerol, [10]-gingerol, and [6]-shogaol, which through different mechanisms can be beneficial in metabolic syndrome. Ginger has a beneficial role in metabolic syndrome treatment due to its hypotensive, anti-obesity, hypoglycemic, and hypolipidemic effects. It can significantly reduce atherosclerotic lesion areas, VLDL and LDL cholesterol levels, and elevate adenosine deaminase activity in platelet and lymphocytes. Also, it promotes ATP/ADP hydrolysis. In the current article review, the critical properties of ginger and its constituents' effects on the metabolic syndrome with a special focus on different molecular and cellular mechanisms have been discussed. This article also suggests that ginger may be introduced as a therapeutic or preventive agent against metabolic syndrome after randomized clinical trials.
C1 [Salaramoli, Sanaz; Yarmohammadi, Fatemeh] Mashhad Univ Med Sci, Student Res Comm, Mashhad, Razavi Khorasan, Iran.
   [Salaramoli, Sanaz; Hashemy, Seyed Isaac] Mashhad Univ Med Sci, Fac Med, Dept Clin Biochem, Mashhad, Razavi Khorasan, Iran.
   [Mehri, Soghra; Hosseinzadeh, Hossein] Mashhad Univ Med Sci, Pharmaceut Res Ctr, Pharmaceut Technol Inst, Mashhad, Razavi Khorasan, Iran.
   [Mehri, Soghra; Yarmohammadi, Fatemeh; Hosseinzadeh, Hossein] Mashhad Univ Med Sci, Sch Pharm, Dept Pharmacodynam & Toxicol, Mashhad, Razavi Khorasan, Iran.
C3 Mashhad University of Medical Sciences; Mashhad University of Medical
   Sciences; Mashhad University of Medical Sciences; Mashhad University of
   Medical Sciences
RP Mehri, S; Hosseinzadeh, H (corresponding author), Mashhad Univ Med Sci, Pharmaceut Res Ctr, Pharmaceut Technol Inst, Mashhad, Razavi Khorasan, Iran.
EM mehris@mums.ac.ir; hosseinzadehh@mums.ac.ir
RI mehri, soghra/P-2939-2018; Yarmohammadi, Fatemeh/GQQ-1975-2022;
   Hosseinzadeh, Hossein/F-3013-2010; Hashemy, Seyed/A-2693-2017
OI Salaramoli, Sanaz/0000-0001-7140-772X; Yarmohammadi,
   Fatemeh/0000-0002-0552-8766
FU Mashhad University of Medical Sciences, Mashhad, Iran
FX This study was supported by Mashhad University of Medical Sciences,
   Mashhad, Iran.
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NR 124
TC 19
Z9 19
U1 1
U2 11
PU MASHHAD UNIV MED SCIENCES
PI MASHHAD
PA VICE-CHANCELLOR FOR RES CTR OFF IJBMS, DANESHGAH ST, PO BOX 9138813944 -
   445, MASHHAD, 00000, IRAN
SN 2008-3866
EI 2008-3874
J9 IRAN J BASIC MED SCI
JI Iran. J. Basic Med. Sci.
PD JUN
PY 2022
VL 25
IS 6
BP 664
EP 674
PG 11
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA 3D7BH
UT WOS:000829452200001
PM 35949312
DA 2025-06-11
ER

PT J
AU Azizi, R
   Soltani-Zangbar, MS
   Sheikhansari, G
   Pourmoghadam, Z
   Mehdizadeh, A
   Mandipour, M
   Sandoghchian, S
   Danaii, S
   Koushaein, L
   Kafil, HS
   Yousefi, M
AF Azizi, Ramyar
   Soltani-Zangbar, Mohammad Sadegh
   Sheikhansari, Golshan
   Pourmoghadam, Zahra
   Mehdizadeh, Amir
   Mandipour, Mandi
   Sandoghchian, Siamak
   Danaii, Shahla
   Koushaein, Ladan
   Kafil, Hossein Samadi
   Yousefi, Mehdi
TI Metabolic syndrome mediates inflammatory and oxidative stress responses
   in patients with recurrent pregnancy loss
SO JOURNAL OF REPRODUCTIVE IMMUNOLOGY
LA English
DT Article
DE Recurrent pregnancy loss; Metabolic syndrome; Oxidative stress;
   Inflammation
ID REGULATORY T-CELLS; SUPEROXIDE-DISMUTASE; SPONTANEOUS-ABORTION;
   GENE-EXPRESSION; INFERTILITY; WOMEN; ACCUMULATION; MISCARRIAGE; DISEASE;
   DECIDUA
AB Recurrent pregnancy loss (RPL) is defined as three or more consecutive pregnancy losses prior to the 20th week of gestation. Exaggerated maternal immune response and oxidative stress status have been proposed as one of the main underlying mechanisms for RPL. The aim of this study was to evaluate the role of inflammatory pathway and oxidative stress imbalance in RPL patients with or without metabolic syndrome (MetS). 21 and 28 RPL patients with (RPL-MS) and without (RPL-NMS) metabolic syndrome were enrolled in this clinical study. 42 healthy women also were considered as the control group. The levels of IL1 beta, IL6, IL17, TNF alpha, CCL2, CXCL8 were evaluated by ELISA method. Additionally, the oxidative stress biomarkers including TAS, TOS, NO, CAT, SOD, AOPP, MPO were analyzed by spectrophotometry. The expression levels of IL1 beta, IL6, IL17, TNF alpha, CCL2, CXCL8, NF kappa B, AP1, miR-21, miR-146-a, miR-223 were also assessed by real time PCR. The frequency of Th17 and T-reg cells was also measured by flow cytometry. Significant increase in the expression levels of IL1 beta, IL6, IL17, TNF alpha, CCL2, CXCL8, NF kappa B, AP1 and miR-21 was observed in RPL-MS patients. Furthermore, significant decreased expression levels of FoxP3, miR-146-a and miR-223 was also observed in RPL-MS group. The levels of IL1 beta, IL6, IL17, TNF alpha, CCL2, CXCL8, NO, MPO and TOS were found to be higher in RPL-MS group compared to the RPL-NMS and healthy controls. In contrast, the level of CAT and SOD in RPL-MS patients was decreased. The frequency of Th17 and Treg cells was also higher and lower in RPL-MS patients compared to the other groups, respectively. Our results support the concept that subclinical inflammatory state, oxidative stress and metabolic syndrome play a crucial role in the etiopathogenesis of RPL assisting clinicians for pregnancy consequences prediction.
C1 [Azizi, Ramyar; Sheikhansari, Golshan; Pourmoghadam, Zahra] Tabriz Univ Med Sci, Aging Res Inst, Tabriz, Iran.
   [Azizi, Ramyar] Tabriz Univ Med Sci, Sch Med, Students Res Comm, Tabriz, Iran.
   [Mandipour, Mandi; Yousefi, Mehdi] Tabriz Univ Med Sci, Stem Cell Res Ctr, Tabriz, Iran.
   [Soltani-Zangbar, Mohammad Sadegh; Sandoghchian, Siamak; Yousefi, Mehdi] Tabriz Univ Med Sci, Fac Med, Dept Immunol, Tabriz, Iran.
   [Mehdizadeh, Amir] Tabriz Univ Med Sci, Endocrine Res Ctr, Tabriz, Iran.
   [Danaii, Shahla] Eastern Azerbaijan ACECR ART Ctr, Eastern Azerbaijan Branch ACECR, Gynecol Dept, Tabriz, Iran.
   [Koushaein, Ladan] Tabriz Univ Med Sci, Womens Reprod Hlth Res Ctr, Tabriz, Iran.
   [Kafil, Hossein Samadi] Tabriz Univ Med Sci, Drug Appl Res Ctr, Tabriz, Iran.
C3 Tabriz University of Medical Science; Tabriz University of Medical
   Science; Tabriz University of Medical Science; Tabriz University of
   Medical Science; Tabriz University of Medical Science; Tabriz University
   of Medical Science; Tabriz University of Medical Science
RP Yousefi, M (corresponding author), Tabriz Univ Med Sci, Fac Med, Dept Immunol, Tabriz, Iran.
EM Yousefime@tbzmed.ac.ir
RI Samadi Kafil, Hossein/AAX-2888-2021; yousefi, mehdi/HHZ-3147-2022;
   pourmoghadam, zahra/AAR-9828-2021; Azizi, Ramyar/AFR-5747-2022;
   Soltani-Zangbar, Mohammad Sadegh/AAC-2625-2022; Samadi Kafil,
   Hossein/B-5855-2012
OI Danaii, Shahla/0000-0002-2800-1975; Mahdipour,
   Mahdi/0000-0002-2729-4593; Sandoghchian Shotorbani,
   Siamak/0000-0002-9456-7651; Pourmoghadam, Zahra/0000-0002-0574-7416;
   azizi, ramyar/0000-0003-1754-922X; Samadi Kafil,
   Hossein/0000-0001-6026-8795; Soltani-Zangbar, Mohammad
   Sadegh/0000-0003-3960-5712; Yousefi, Mehdi/0000-0003-0099-6728
FU Stem Cell Research Center, Tabriz University of Medical Sciences,
   Tabriz, Iran [59661]
FX We wish to thank all the healthy volunteers and patients who
   participated in this study. This study was financially supported by the
   grant of Stem Cell Research Center, Tabriz University of Medical
   Sciences, Tabriz, Iran (Grant No. 59661).
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NR 46
TC 40
Z9 42
U1 1
U2 5
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0165-0378
EI 1872-7603
J9 J REPROD IMMUNOL
JI J. Reprod. Immunol.
PD JUN
PY 2019
VL 133
BP 18
EP 26
DI 10.1016/j.jri.2019.05.001
PG 9
WC Immunology; Reproductive Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Reproductive Biology
GA IR6PI
UT WOS:000481560800004
PM 31100644
DA 2025-06-11
ER

PT J
AU Hamer, M
   Stamatakis, E
   Mishra, GD
AF Hamer, Mark
   Stamatakis, Emmanuel
   Mishra, Gita D.
TI Television- and Screen-Based Activity and Mental Well-Being in Adults
SO AMERICAN JOURNAL OF PREVENTIVE MEDICINE
LA English
DT Article
ID PHYSICAL-ACTIVITY; METABOLIC SYNDROME; DEPRESSIVE SYMPTOMS; SEDENTARY
   TIME; RISK-FACTORS; HEALTH; OBESITY; MORTALITY; VALIDITY
AB Background: Sedentary behavior is emerging as an independent risk factor for physical health, although there is no existing evidence regarding mental well-being.
   Purpose: This study aimed to examine the association between recreational sedentary behavior (based on TV- and screen-based entertainment [TVSE] time) and mental health in a representative sample of adults
   Methods: Participants were 3920 men and women (mean age 51 0 +/- 15.8 years) from the 2003 Scottish Health Survey. The General Health Questionnaire (GHQ-12) and the mental health component of the 12-Item Short-Form Survey Instrument (MCS-12) were administered to obtain information on current mental health. Self-reported TVSE time, physical activity, and physical function was also measured. Analyses were conducted in 2009
   Results: Approximately 2596 of participants engaged in at least 4 hours/day of TVSE In general linear models, TVSE time per week was independently associated with GHQ-12 score (higher scores represent worse mental health status) after adjustment for age, gender, physical activity, physical function, area deprivation level, smoking, alcohol, fruit and vegetable intake, and BM I After full adjustment, participants in the group with the highest TVSE level (>4 hours/day) had an increase in GHQ-12 score of 0.28 (95% CI = 0 05, 0.51) compared with participants in the group with the lowest TVSE level (<= 2 hours/day). In stratified analyses, the association between TVSE time and GHQ-12 score persisted across all physical activity levels. Similar associations were observed using the MCS-12
   Conclusions: Sedentary behavior in leisure time is independently associated with poorer mental health scores in a representative population sample. (Am J Prev Med 2010,38(4) 375-380) (C) 2010 American Journal of Preventive Medicine
C1 [Hamer, Mark; Stamatakis, Emmanuel; Mishra, Gita D.] UCL, Dept Epidemiol & Publ Hlth, London WC1E 6BT, England.
C3 University of London; University College London
RP Hamer, M (corresponding author), UCL, Dept Epidemiol & Publ Hlth, 1-19 Torrington Pl, London WC1E 6BT, England.
RI Mishra, Gita/F-8052-2011; Stamatakis, Emmanuel/C-4958-2009; Hamer,
   Mark/C-1602-2008
OI Hamer, Mark/0000-0002-8726-7992
FU National Institute for Health Research, United Kingdom; Medical Research
   Council, United Kingdom; Scottish Executive; MRC [MC_U123092725] Funding
   Source: UKRI
FX The authors receive grant funding from the National Institute for Health
   Research, United Kingdom, and the Medical Research Council, United
   Kingdom. The Scottish Health Survey is funded by the Scottish Executive.
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NR 30
TC 134
Z9 151
U1 0
U2 32
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0749-3797
EI 1873-2607
J9 AM J PREV MED
JI Am. J. Prev. Med.
PD APR
PY 2010
VL 38
IS 4
BP 375
EP 380
DI 10.1016/j.amepre.2009.12.030
PG 6
WC Public, Environmental & Occupational Health; Medicine, General &
   Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; General & Internal Medicine
GA 580AS
UT WOS:000276419500004
PM 20307805
DA 2025-06-11
ER

PT J
AU Al-kuraishy, HM
   Jabir, MS
   Albuhadily, AK
   Al-Gareeb, AI
   Rafeeq, MF
AF Al-kuraishy, Haydar M.
   Jabir, Majid S.
   Albuhadily, Ali K.
   Al-Gareeb, Ali I.
   Rafeeq, Mayyadah F.
TI The link between metabolic syndrome and Alzheimer disease: A mutual
   relationship and long rigorous investigation
SO AGEING RESEARCH REVIEWS
LA English
DT Review
DE Metabolic syndrome; Alzheimer disease; Amyloid beta; Insulin resistance;
   Obesity; Hypertension
ID BRAIN INSULIN-RESISTANCE; AMYLOID-BETA-PROTEIN; NF-KAPPA-B;
   DIABETES-MELLITUS; OXIDATIVE STRESS; A-BETA; RISK-FACTOR; INFLAMMATION;
   ACID; PATHOGENESIS
AB It has been illustrated that metabolic syndrome (MetS) is associated with Alzheimer disease (AD) neuropathology. Components of MetS including central obesity, hypertension, insulin resistance (IR), and dyslipidemia adversely affect the pathogenesis of AD by different mechanisms including activation of renin-angiotensin system (RAS), inflammatory signaling pathways, neuroinflammation, brain IR, mitochondrial dysfunction, and oxidative stress. MetS exacerbates AD neuropathology, and targeting of molecular pathways in MetS by pharmacological approach could a novel therapeutic strategy in the management of AD in high risk group. However, the underlying mechanisms of these pathways in AD neuropathology are not completely clarified. Therefore, this review aims to elucidate the association between MetS and AD regarding the oxidative and inflammatory mechanistic pathways.
C1 [Al-kuraishy, Haydar M.; Albuhadily, Ali K.; Al-Gareeb, Ali I.] Mustansiriyah Univ, Coll Med, Dept Clin pharmacol & Med, Baghdad, Iraq.
   [Jabir, Majid S.; Rafeeq, Mayyadah F.] Technol Univ, Dept Appl Sci, Baghdad, Iraq.
C3 Mustansiriya University; University of Technology- Iraq
RP Jabir, MS (corresponding author), Technol Univ, Dept Appl Sci, Baghdad, Iraq.
EM 100131@uotechnology.edu.iq
RI Jabir, Majid/J-9683-2019; al-kuraishy, hayder/AAE-6673-2019; Al-Gareeb,
   Ali/I-8330-2019
OI Al-Gareeb, Ali/0000-0001-8284-8897
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   Zhang HQ, 2021, INT J BIOL SCI, V17, P2181, DOI 10.7150/ijbs.57078
   Zhang Y, 2018, BEHAV BRAIN RES, V339, P57, DOI 10.1016/j.bbr.2017.11.015
   Zhao WH, 2019, BIOMED PHARMACOTHER, V118, DOI 10.1016/j.biopha.2019.108940
NR 180
TC 37
Z9 37
U1 2
U2 10
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 1568-1637
EI 1872-9649
J9 AGEING RES REV
JI Ageing Res. Rev.
PD NOV
PY 2023
VL 91
AR 102084
DI 10.1016/j.arr.2023.102084
EA OCT 2023
PG 10
WC Cell Biology; Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Geriatrics & Gerontology
GA W7BW6
UT WOS:001093152300001
PM 37802319
DA 2025-06-11
ER

PT J
AU Chytilová, E
   Malík, J
   Kasalová, Z
   Dolezalová, R
   Stulc, T
   Ceska, R
AF Chytilova, E.
   Malik, J.
   Kasalova, Z.
   Dolezalova, R.
   Stulc, T.
   Ceska, R.
TI Lower Wall Shear Rate of the Common Carotid Artery in Treated Type 2
   Diabetes Mellitus with Metabolic Syndrome
SO PHYSIOLOGICAL RESEARCH
LA English
DT Article
DE Ultrasonography; Wall shear stress; Wall shear rate; Diabetes mellitus;
   Carotid artery disease
ID INTIMA-MEDIA THICKNESS; RISK-FACTORS; FLOW-VELOCITY; BLOOD-FLOW;
   ATHEROSCLEROSIS; ASSOCIATION; STRESS; CIRCULATION; PROGRESSION; PRESSURE
AB Arterial sites with low wall shear stress (WSS) are more prone to the development of atherosclerotic plaques, as was observed in carotid arteries in subjects with atherosclerosis risk factors. Type 2 diabetes mellitus (DM), hypertension, hyperlipidemia and other components of the metabolic syndrome, are associated with high risk for symptomatic cerebrovascular disease. It was shown by others that untreated type 2 DM is associated with lower WSS in common carotid arteries. However, the cardiovascular risk of type 2 DM could be modified by therapy. The aim of our study was to test the hypothesis that treated type 2 DM subjects with metabolic syndrome still have lower WSS in common carotid arteries than healthy controls. We enrolled 26 compensated DM subjects with metabolic syndrome, treated by metformin, statins and ACEI for more than 6 months, and 22 aged-comparable healthy controls. Wall shear rate (WSR) was used as a measure of WSS. A linear 3-11 MHz probe was used to measure blood velocity and internal diameter in the common carotid arteries. We compared observed values of WSR adjusted for age by ANCOVA. Wall shear rate was significantly lower in DM group than in control subjects: peak (systolic) values of wall shear rate were 410 +/- 130 s(-1) vs. 487 +/- 111 s(-1) (p<0.005). DM subjects had significantly lower WSR, because of both thinner lumen and slower blood flow velocities. Lower WSR was accompanied by higher IMT (0.73 +/- 0.12 mm vs. 0.64 +/- 0.11 mm, p<0.001). Treated subjects with compensated type 2 DM with metabolic syndrome still have atherogenic hemodynamic profile. These findings might help to understand faster progression of atherosclerosis in diabetic subjects with metabolic syndrome despite up-to-date medication.
C1 [Chytilova, E.] Gen Univ Hosp, Dept Internal Med 3, U Nemocnice 1, Prague 12808 2, Czech Republic.
   Charles Univ Prague, Sch Med 1, Prague, Czech Republic.
C3 General University Hospital Prague; Charles University Prague
RP Chytilová, E (corresponding author), Gen Univ Hosp, Dept Internal Med 3, U Nemocnice 1, Prague 12808 2, Czech Republic.
EM Eva.Chytilova@vfn.cz
RI Ceska, Richard/A-1840-2017; Malik, Jan/C-4826-2008; Stulc,
   Tomas/M-1325-2017; Chytilova, Eva/A-1901-2017; Petrakova Dolezalova,
   Radka/T-3415-2017; Krupickova, Zdislava/T-5419-2017
OI Ceska, Richard/0000-0002-2541-5179; Malik, Jan/0000-0002-2386-3293;
   Stulc, Tomas/0000-0002-9066-3566; Chytilova, Eva/0000-0002-9283-3661;
   Petrakova Dolezalova, Radka/0000-0003-1092-7312; Krupickova,
   Zdislava/0000-0003-3680-3326
FU Ministry of Education, Czech Republic [MSM 0021620807]
FX The study was supported by the Research Project MSM 0021620807 of
   Ministry of Education, Czech Republic.
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NR 44
TC 12
Z9 12
U1 0
U2 6
PU ACAD SCIENCES CZECH REPUBLIC, INST PHYSIOLOGY
PI PRAGUE 4
PA VIDENSKA 1083, PRAGUE 4 142 20, CZECH REPUBLIC
SN 0862-8408
EI 1802-9973
J9 PHYSIOL RES
JI Physiol. Res.
PY 2009
VL 58
IS 2
BP 185
EP 191
DI 10.33549/physiolres.931445
PG 7
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA 442PM
UT WOS:000265853100004
PM 18380538
OA gold
DA 2025-06-11
ER

PT J
AU Borges, RL
   Ribeiro, AB
   Zanella, MT
   Batista, MC
AF Borges, Rodolfo Leao
   Ribeiro, Artur Beltrame
   Zanella, Maria Teresa
   Batista, Marcelo Costa
TI Uric Acid as a Factor in the Metabolic Syndrome
SO CURRENT HYPERTENSION REPORTS
LA English
DT Article
DE Uric acid; Metabolic syndrome; Chronic kidney disease; Cardiovascular
   risk
ID ISCHEMIC-HEART-DISEASE; RISK-FACTOR; BLOOD-PRESSURE; RENAL-DISEASE;
   CARDIOVASCULAR-DISEASE; ESSENTIAL-HYPERTENSION; OXIDATIVE STRESS;
   SEX-DIFFERENCES; SERUM; HYPERURICEMIA
AB Hyperuricemia is a prevalent finding in patients presenting metabolic syndrome, although its clinical meaning is still controversial and often underestimated. Men and women have different serum urate levels at all ages, and the impact of hyperuricemia in cardiovascular and renal outcomes is generally associated with a worse prognosis in women. Recent studies also have called attention to another perspective on hyperuricemia, indicating that it may be not only a consequence of insulin resistance states but also a significant predictor of the development of metabolic syndrome. This review discusses recent evidence related to the clinical significance of hyperuricemia in both sexes and the potential benefits of lowering serum uric acid levels.
RP Borges, RL (corresponding author), Rua Leandro Dupret,365,Vila Clementino, BR-04025011 Sao Paulo, Brazil.
EM endorodolfo@uol.com.br; abribeiro@nefro.epm.br; zanellamt@uol.com.br;
   mcbatista@uol.com.br
RI Batista, Marcelo/K-4305-2013; Ribeiro, Artur/IQS-0344-2023; Zanella,
   Maria Teresa/HSF-7197-2023
OI Zanella, Maria Teresa/0000-0002-8451-8522
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NR 54
TC 70
Z9 78
U1 0
U2 8
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1522-6417
EI 1534-3111
J9 CURR HYPERTENS REP
JI Curr. Hypertens. Rep.
PD APR
PY 2010
VL 12
IS 2
BP 113
EP 119
DI 10.1007/s11906-010-0098-2
PG 7
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 596XR
UT WOS:000277719600011
PM 20424936
DA 2025-06-11
ER

PT J
AU Perelman, MA
AF Perelman, Michael A.
TI Erectile Dysfunction and Depression: Screening and Treatment
SO UROLOGIC CLINICS OF NORTH AMERICA
LA English
DT Article
DE Depression; Erectile dysfunction; Sexual dysfunction; Metabolic
   syndrome; Combination treatment
ID INDUCED SEXUAL DYSFUNCTION; NOCTURNAL PENILE TUMESCENCE; BUPROPION
   SUSTAINED-RELEASE; DOUBLE-BLIND; MAJOR DEPRESSION; COMBINATION
   TREATMENT; SILDENAFIL CITRATE; INDUCED ANORGASMIA; MEN; ANTIDEPRESSANT
AB The comorbid conditions erectile dysfunction (ED) and depression are highly prevalent in men. Multiple regression analysis to control for all other predictors of ED indicate that men with high depression scores are nearly twice as likely to report ED than nondepressed men. Depression continues to be among the most common comorbid problems in men with ED, both in the community and in clinical samples. This article reviews the current knowledge about the relationship between ED and depression, the effect of treatments for depression on ED, ways to improve screening for depression, and treatment of ED in patients with this comorbidity.
C1 [Perelman, Michael A.] New York Presbyterian Hosp, Human Sexual Program, Payne Whitney Clin, New York, NY USA.
   [Perelman, Michael A.] Cornell Univ, New York Weill Med Coll, New York, NY 10021 USA.
C3 NewYork-Presbyterian Hospital; Cornell University
RP Perelman, MA (corresponding author), 70 E 77th St,Suite 1C, New York, NY 10075 USA.
EM perelman@earthlink.net
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NR 127
TC 24
Z9 30
U1 0
U2 8
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0094-0143
EI 1558-318X
J9 UROL CLIN N AM
JI Urol. Clin. N. Am.
PD MAY
PY 2011
VL 38
IS 2
BP 125
EP +
DI 10.1016/j.ucl.2011.03.004
PG 16
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Urology & Nephrology
GA 780YK
UT WOS:000291897100005
PM 21621079
DA 2025-06-11
ER

PT J
AU Kim, JT
   Lee, HK
AF Kim, Jin Taek
   Lee, Hong Kyu
TI Metabolic syndrome and the environmental pollutants from mitochondrial
   perspectives
SO REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
LA English
DT Review
DE Endocrine disrupting chemicals (EDCs); Persistent organic pollutants
   (POPs); Mitochondrial dysfunction; Insulin resistance; Metabolic
   syndrome
ID ENDOCRINE-DISRUPTING CHEMICALS; PERSISTENT ORGANIC POLLUTANTS;
   DIABETES-MELLITUS; AIR-POLLUTION; INSULIN-RESISTANCE; CIRCULATING
   LEVELS; OXIDATIVE STRESS; DYSFUNCTION; EXPOSURE; MECHANISMS
AB The worldwide epidemic of diabetes and metabolic syndrome in the last few decades cannot be fully accounted for only by changes in the lifestyle factors, such as sedentary lifestyle and overeating. Besides genetic factors, there must be other causes to explain this rapid change. They could not be infectious in nature and induce insulin resistance as key biochemical abnormality. Mitochondrial dysfunction could be underlying mechanism behind the insulin resistance, thus metabolic syndrome. Then there have been increasing number of reports suggesting that chronic exposure to and accumulation of endocrine disrupting chemicals (EDCs), especially so-called the persistent organic pollutants (POPs) within the body might be associated with metabolic syndrome. Combining two concepts, we developed new "EDCs-induced mitochondrial dysfunction hypothesis of metabolic syndrome". In this review we suggest that classifying those chemicals into 5 groups might be clinically useful considering their removal or avoidance; POPs, non-persistent organic pollutants, heavy metals, air pollutants and drugs. We will also discuss briefly how those insights could be applied to clinical medicine.
C1 [Kim, Jin Taek; Lee, Hong Kyu] Eulji Univ, Dept Internal Med, Coll Med, Seoul, South Korea.
C3 Eulji University
RP Lee, HK (corresponding author), Eulji Univ, Dept Internal Med, Coll Med, Seoul, South Korea.
EM hkleemd@eulji.ac.kr
FU MIC & IITA through the IT Leading R & D Support Project
FX This work was supported in part by MIC & IITA through the IT Leading R &
   D Support Project.
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NR 74
TC 28
Z9 29
U1 1
U2 35
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1389-9155
EI 1573-2606
J9 REV ENDOCR METAB DIS
JI Rev. Endocr. Metab. Disord.
PD DEC
PY 2014
VL 15
IS 4
BP 253
EP 262
DI 10.1007/s11154-014-9297-5
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA AU0TW
UT WOS:000345338400002
PM 25391628
DA 2025-06-11
ER

PT J
AU Iqbal, N
   Cardillo, S
   Volger, S
   Bloedon, LT
   Anderson, RA
   Boston, R
   Szapary, PO
AF Iqbal, Nayyar
   Cardillo, Serena
   Volger, Sheri
   Bloedon, LeAnne T.
   Anderson, Richard A.
   Boston, Raymond
   Szapary, Philippe O.
TI Chromium Picolinate Does Not Improve Key Features of Metabolic Syndrome
   in Obese Nondiabetic Adults
SO METABOLIC SYNDROME AND RELATED DISORDERS
LA English
DT Article; Proceedings Paper
CT 66th Annual Meeting of the American-Diabetes-Association
CY JUN 09-13, 2006
CL Washington, DC
SP Amer Diabet Assoc
ID INSULIN SENSITIVITY; GLUCOSE-METABOLISM; BODY-WEIGHT; OLDER MEN;
   SUPPLEMENTATION; NONOBESE; HEALTHY
AB Background: The use of chromium-containing dietary supplements is widespread among patients with type 2 diabetes. Chromium's effects in patients at high risk for developing diabetes, especially those with metabolic syndrome, is unknown. The objective of this study was to determine the effects of chromium picolinate (CrPic) on glucose metabolism in patients with metabolic syndrome.
   Method: A double-blind, placebo-controlled, randomized trial was conducted at a U. S. academic medical center. Sixty three patients with National Cholesterol Education Program (NCEP) Adult Treatment Panel III (ATP III)-defined metabolic syndrome were included. The primary end point was a change in the insulin sensitivity index derived from a frequently sampled intravenous glucose tolerance test. Prespecified secondary end points included changes in other measurements of glucose metabolism, oxidative stress, fasting serum lipids, and high sensitivity C-reactive protein.
   Results: After 16 weeks of CrPic treatment, there was no significant change in insulin sensitivity index between groups (P = 0.14). However, CrPic increased acute insulin response to glucose (P = 0.02). CrPic had no significant effect on other measures of glucose metabolism, body weight, serum lipids, or measures of inflammation and oxidative stress.
   Conclusion: CrPic at 1000 mu g/day does not improve key features of the metabolic syndrome in obese nondiabetic patients.
C1 [Szapary, Philippe O.] Univ Penn Hlth Syst, Philadelphia Heart Inst, Div Gen Internal Med, Inst Translat Med & Therapeut,CRIP,Dept Med, Philadelphia, PA 19104 USA.
   [Iqbal, Nayyar; Cardillo, Serena] Univ Penn Hlth Syst, Div Endocrinol Diabet & Metab, Philadelphia, PA 19104 USA.
   [Volger, Sheri; Bloedon, LeAnne T.; Szapary, Philippe O.] Univ Penn Hlth Syst, Ctr Clin Epidemiol & Biostat, Philadelphia, PA 19104 USA.
   [Iqbal, Nayyar] Philadelphia Vet Affairs Med Ctr, Philadelphia, PA USA.
   [Boston, Raymond] Univ Penn, Sch Vet Med, Dept Clin Studies, Biostat Sect,New Bolton Ctr, Kennett Sq, PA 19348 USA.
   [Anderson, Richard A.] USDA, Beltsville Human Nutr Res Ctr, Beltsville, MD 20705 USA.
C3 University of Pennsylvania; University of Pennsylvania; University of
   Pennsylvania; University of Pennsylvania; Pennsylvania Medicine; US
   Department of Veterans Affairs; Veterans Health Administration (VHA);
   Philadelphia Veterans Affairs Medical Center; University of
   Pennsylvania; United States Department of Agriculture (USDA)
RP Szapary, PO (corresponding author), Univ Penn Hlth Syst, Philadelphia Heart Inst, Div Gen Internal Med, Inst Translat Med & Therapeut,CRIP,Dept Med, Suite 2A,39th & Market St, Philadelphia, PA 19104 USA.
EM philippe.szapary@uphs.upenn.edu
OI volger, sheri/0000-0002-1689-1173
FU NCCIH NIH HHS [K-23 AT-00058] Funding Source: Medline; NCRR NIH HHS
   [M01-RR00040] Funding Source: Medline; NIDDK NIH HHS [R21DK067241]
   Funding Source: Medline
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U2 6
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-4196
EI 1557-8518
J9 METAB SYNDR RELAT D
JI Metab. Syndr. Relat. Disord.
PD APR
PY 2009
VL 7
IS 2
BP 143
EP 150
DI 10.1089/met.2008.0048
PG 8
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Research & Experimental Medicine
GA 438XP
UT WOS:000265589900010
PM 19422140
OA Green Published
DA 2025-06-11
ER

PT J
AU Nikbakht-Jam, I
   Khademi, MM
   Nosrati, M
   Eslami, S
   Foroutan-Tanha, M
   Sahebkar, AH
   Tavalaie, S
   Ghayour-Mobarhan, M
   Ferns, GAA
   Hadizadeh, F
   Tabasi, SAS
   Mohajeri, SA
   Emamian, M
AF Nikbakht-Jam, Irandokht
   Khademi, Mohammad-Matin
   Nosrati, Mina
   Eslami, Saeid
   Foroutan-Tanha, Mojtaba
   Sahebkar, Amir-Hossein
   Tavalaie, Shima
   Ghayour-Mobarhan, Majid
   Ferns, Gordon A. A.
   Hadizadeh, Farzin
   Tabasi, Seyed-Abolghasem Sajjadi
   Mohajeri, Seyed-Ahmad
   Emamian, Marzieh
TI Effect of crocin extracted from saffron on pro-oxidant-anti-oxidant
   balance in subjects with metabolic syndrome: A randomized,
   placebo-controlled clinical trial
SO EUROPEAN JOURNAL OF INTEGRATIVE MEDICINE
LA English
DT Article
DE Crocin; Oxidative stress; PAB; Metabolic syndrome; Saffron
ID PROOXIDANT-ANTIOXIDANT BALANCE; OXIDATIVE STRESS; CARDIOVASCULAR RISK;
   TOXICITY; ASSOCIATION; PREVALENCE; OBESITY; ACID
AB Introduction: Oxidative stress is associated with metabolic syndrome and cardiovascular disease. Crocin, is a natural carotenoid that has anti-oxidant properties. The aim of this study was to investigate the effect of a crocin preparation extracted from saffron on a measure of serum pro-oxidant/ anti-oxidant status in subjects with metabolic syndrome.
   Methods: This randomized placebo-controlled clinical trial (RCT) was carried out on 60 volunteers with metabolic syndrome. The latter was defined using the International Diabetes Federation (IDF) criteria. Participants were randomly allocated to one of two groups of 30 subjects as the intervention and control groups. The intervention group received crocin tablets for 8 weeks at a dose of 15 mg twice a day; the control group were given a placebo over the same period. Blood samples were taken before and after the intervention period. Pro-oxidant-anti-oxidant balance (PAB) assay was used to evaluate the change in serum pro-oxidant, anti-oxidant balance.
   Results: Mean serum PAB fell by 11.7% in the intervention group (p: 0.006), whilst there was no significant change in serum PAB in the control group (p > 0.05). The change in mean serum PAB was statistically significant between the groups (p = 0.014). No statistically significant differences were observed in fasting blood glucose (FBG) and blood lipid profile (including cholesterol, triglycerides, LDL and HDL) between the two groups before and after the intervention (p > 0.05).
   Conclusion: This study demonstrates that crocin, a derivative of saffron, at a dose of 30 mg/d can significantly reduce serum PAB in individuals with metabolic syndrome. (C) 2015 Elsevier GmbH. All rights reserved.
C1 [Nikbakht-Jam, Irandokht; Nosrati, Mina; Sahebkar, Amir-Hossein; Tavalaie, Shima; Ghayour-Mobarhan, Majid; Emamian, Marzieh] Mashhad Univ Med Sci, Sch Med, Biochem & Nutr Res Ctr, Mashhad, Iran.
   [Khademi, Mohammad-Matin] Mashhad Univ Med Sci, Sch Pharm, Student Res Comm, Mashhad, Iran.
   [Eslami, Saeid; Foroutan-Tanha, Mojtaba] Mashhad Univ Med Sci, Sch Pharm, Pharmaceut Res Ctr, Mashhad, Iran.
   [Ghayour-Mobarhan, Majid] Mashhad Univ Med Sci, Sch Med, Cardiovasc Res Ctr, Mashhad, Iran.
   [Ferns, Gordon A. A.] Brighton & Sussex Med Sch, Div Med Educ, Mayfield House, Brighton BN1 9PH, Sussex, England.
   [Hadizadeh, Farzin] Mashhad Univ Med Sci, Sch Pharm, Biotechnologyl Res Ctr, Mashhad, Iran.
   [Tabasi, Seyed-Abolghasem Sajjadi; Mohajeri, Seyed-Ahmad] Mashhad Univ Med Sci, Sch Med, Pharmacol Res Ctr Med Plants, Mashhad, Iran.
C3 Mashhad University of Medical Sciences; Mashhad University of Medical
   Sciences; Mashhad University of Medical Sciences; Mashhad University of
   Medical Sciences; University of Brighton; University of Sussex; Mashhad
   University of Medical Sciences; Mashhad University of Medical Sciences
RP Ghayour-Mobarhan, M (corresponding author), Mashhad Univ Med Sci, Sch Med, Biochem & Nutr Res Ctr, Mashhad, Iran.; Hadizadeh, F (corresponding author), Mashhad Univ Med Sci, Sch Pharm, Biotechnologyl Res Ctr, Mashhad, Iran.
EM GhayourM@mums.ac.ir; HadizadehF@mums.ac.ir
RI Hadizadeh, Farzin/AAG-2067-2019; Sahebkar, Amirhossein/B-5124-2018;
   Ghayour-Mobarhan, Majid/AAY-5963-2020; Eslami, Saeid/AAZ-6005-2020;
   Mohajeri, Seyed/AAC-9715-2019
OI Nikbakht Jam, Irandokht/0000-0002-4371-4586
FU Mashhad University of Medical Science (MUMS), Mashhad, Iran
FX This study was part of a thesis to earn a Master of Science degree in
   nutrition science from the Mashhad University of Medical science,
   Mashhad, Iran. We thank and appreciate the subjects that voluntarily
   participated in this study. This work was supported by Mashhad
   University of Medical Science (MUMS), Mashhad, Iran.
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NR 30
TC 58
Z9 59
U1 2
U2 11
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1876-3820
EI 1876-3839
J9 EUR J INTEGR MED
JI Eur. J. Integr. Med.
PD JUN
PY 2016
VL 8
IS 3
BP 307
EP 312
DI 10.1016/j.eujim.2015.12.008
PG 6
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA DT8JI
UT WOS:000381735900026
DA 2025-06-11
ER

PT J
AU Del Turco, S
   Bastiani, L
   Minichilli, F
   Landi, P
   Basta, G
   Pingitore, A
   Vassalle, C
AF Del Turco, Serena
   Bastiani, Luca
   Minichilli, Fabrizio
   Landi, Patrizia
   Basta, Giuseppina
   Pingitore, Alessandro
   Vassalle, Cristina
TI Interaction of Uric Acid and Neutrophil-to-Lymphocyte Ratio for
   Cardiometabolic Risk Stratification and Prognosis in Coronary Artery
   Disease Patients
SO ANTIOXIDANTS
LA English
DT Article
DE uric acid; neutrophil-to-lymphocyte ratio; cardiometabolic disease;
   cardiac mortality; hard events
ID ST-SEGMENT ELEVATION; INFARCT-RELATED ARTERY; MYOCARDIAL-INFARCTION;
   CARDIOVASCULAR EVENTS; INFLAMMATORY MARKERS; OXIDATIVE STRESS;
   PREDICTOR; HYPERURICEMIA; PATENCY; GOUT
AB Oxidative stress and inflammation are key factors in cardiometabolic diseases. We set out to evaluate the relationship between serum uric acid (UA) and the neutrophil-to-lymphocyte ratio (NLR) with cardiometabolic risk factors in coronary artery disease (CAD) patients, and their additive and multiplicative interactive effects on outcomes (cardiac death/CD and hard events (HE)-death plus reinfarction). A total of 2712 patients (67 +/- 11 years, 1960 males) who underwent coronary angiography was retrospectively analyzed and categorized into no-CAD patients (n = 806), stable-CAD patients (n = 1545), and patients with acute myocardial infarction (AMI) (n = 361). UA and NLR were reciprocally correlated and associated with cardiometabolic risk factors. During a mean follow-up period of 27 +/- 20 months, 99 +/- 3.6% deaths, and 213 +/- 7.8% HE were registered. The Kaplan-Meier survival estimates showed significantly worse outcomes in patients with elevated UA or NLR levels. Multivariate Cox regression analysis demonstrated that NLR independently predicted CD and HE. There was no multiplicative interaction between UA and NLR; however, the use of measures of additive interaction evidenced a positive additive interaction between UA and NLR for CD and HE. Although it is clear that correlation does not imply causation, the coexistence of NRL and UA appears to have a synergistic effect, providing further information for the risk stratification of CAD patients.
C1 [Del Turco, Serena; Bastiani, Luca; Minichilli, Fabrizio; Landi, Patrizia; Basta, Giuseppina; Pingitore, Alessandro] CNR, Inst Clin Physiol, I-56124 Pisa, Italy.
   [Vassalle, Cristina] Fdn CNR Reg Toscana Gabriele Monasterio, I-56124 Pisa, Italy.
C3 Consiglio Nazionale delle Ricerche (CNR); Istituto di Fisiologia Clinica
   (IFC-CNR)
RP Vassalle, C (corresponding author), Fdn CNR Reg Toscana Gabriele Monasterio, I-56124 Pisa, Italy.
EM cristina.vassalle@ftgm.it
RI Basta, Giuseppina/B-8077-2015; Pingitore, Alessandro/K-1843-2018;
   Minichilli, Fabrizio/HPI-1616-2023; Del Turco, Serena/K-1972-2018;
   LANDI, Patrizia/K-8736-2015
OI Minichilli, Fabrizio/0000-0003-0007-4731; Del Turco,
   Serena/0000-0003-3722-8861; LANDI, Patrizia/0000-0002-8463-5710;
   /0000-0002-5551-205X; VASSALLE, CRISTINA/0000-0003-3438-6450
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NR 39
TC 9
Z9 9
U1 2
U2 14
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD NOV
PY 2022
VL 11
IS 11
AR 2163
DI 10.3390/antiox11112163
PG 12
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA 6U3ZT
UT WOS:000894309000001
PM 36358534
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Miller, A
   Adeli, K
AF Miller, Abigale
   Adeli, Khosrow
TI Dietary fructose and the metabolic syndrome
SO CURRENT OPINION IN GASTROENTEROLOGY
LA English
DT Article
DE fructose; hyperuricemia; insulin resistance; metabolic syndrome;
   oxidative stress
ID SERUM URIC-ACID; GLYCATION END-PRODUCTS; INDUCED INSULIN-RESISTANCE;
   HIGH-FAT DIET; FED RATS; AGE FORMATION; POSTPRANDIAL LIPEMIA;
   INFLAMMATORY MARKERS; ADIPONECTIN LEVELS; HYPERTENSIVE-RATS
AB Purpose of review
   Fructose, a naturally found sugar in many fruits, is now commonly used as an industrial sweetener and is excessively consumed in Western diets. High fructose intake is increasingly recognized as causative in development of prediabetes and metabolic syndrome. The mechanisms underlying fructose-induced metabolic disturbances are unclear but are beginning to be unravelled. This review presents recent findings in this field and an overall mechanistic insight into the metabolic effects of dietary fructose and its role in Metabolic syndrome.
   Recent findings
   Recent animal studies have confirmed the link between fructose feeding and increased plasma uric acid, a potentially causative factor in metabolic syndrome. Advanced glycation end products are also implicated because of their direct protein modifications and indirect effects on inflammation and oxidative stress. Human studies have demonstrated fructose's ability to change metabolic hormonal response, possibly contributing to decreased satiety.
   Summary
   There is much evidence from both animal models and human studies supporting the notion that fructose is a highly lipogenic nutrient that, when consumed in high quantities, contributes to tissue insulin insensitivity, metabolic defects, and the development of a prediabetic state. Recently evidence has helped to decipher the mechanisms involved in these metabolic changes.
C1 [Miller, Abigale; Adeli, Khosrow] Hosp Sick Children, Div Clin Biochem, Mol Struct & Funct Res Inst, Toronto, ON M5G 1X8, Canada.
   [Miller, Abigale; Adeli, Khosrow] Univ Toronto, Dept Biochem, Toronto, ON, Canada.
C3 University of Toronto; Hospital for Sick Children (SickKids); University
   of Toronto
RP Adeli, K (corresponding author), Hosp Sick Children, Div Clin Biochem, Mol Struct & Funct Res Inst, Toronto, ON M5G 1X8, Canada.
EM khosrow.adeli@sickkids.ca
OI Adeli, Khosrow/0000-0002-5839-5709
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   Wei YR, 2007, J NUTR BIOCHEM, V18, P1, DOI 10.1016/j.jnutbio.2006.03.013
NR 57
TC 166
Z9 191
U1 0
U2 32
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0267-1379
EI 1531-7056
J9 CURR OPIN GASTROEN
JI Curr. Opin. Gastroenterol.
PD MAR
PY 2008
VL 24
IS 2
BP 204
EP 209
DI 10.1097/MOG.0b013e3282f3f4c4
PG 6
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 273NB
UT WOS:000253936500016
PM 18301272
DA 2025-06-11
ER

PT J
AU Lois, K
   Young, J
   Kumar, S
AF Lois, K.
   Young, J.
   Kumar, S.
TI Obesity; epiphenomenon or cause of metabolic syndrome?
SO INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
LA English
DT Review
ID INSULIN-RESISTANCE; DIABETES-MELLITUS; OXIDATIVE STRESS; LEPTIN;
   INFLAMMATION; HYPERTENSION
AB Metabolic syndrome is a combination of metabolic-related health issues such as hypertension, hyperlipidaemia and hyperinsulinaemia that together increase significantly the risk of cardiovascular disease and type 2 diabetes. Its prevalence has dramatically increased over the last several decades throughout the world following that of obesity. Insulin resistance and abdominal obesity are considered its core, while the latter may generate via complex metabolic and biochemical pathways the rest parameters of metabolic syndrome. The current approach of treatment is based on treating the chronic cardiovascular malfunctions but there is increasing interest in approaches to managing abdominal obesity as the underlying cause.
C1 [Lois, K.; Young, J.; Kumar, S.] Univ Warwick, Warwick Med Sch, Warwickshire Inst Diabet Endocrinol & Metab, Univ Hosp Walsgrave Site, Coventry CV2 2DX, W Midlands, England.
C3 University of Warwick
RP Lois, K (corresponding author), Univ Warwick, Warwick Med Sch, Warwickshire Inst Diabet Endocrinol & Metab, Univ Hosp Walsgrave Site, Clifford Bridge Rd, Coventry CV2 2DX, W Midlands, England.
EM kblois03@yahoo.gr
RI kumar, sudhesh/D-6945-2013
OI kumar, sudhesh/0000-0003-4326-5941
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NR 50
TC 14
Z9 19
U1 0
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1368-5031
EI 1742-1241
J9 INT J CLIN PRACT
JI Int. J. Clin. Pract.
PD JUN
PY 2008
VL 62
IS 6
BP 932
EP 938
DI 10.1111/j.1742-1241.2008.01773.x
PG 7
WC Medicine, General & Internal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Pharmacology & Pharmacy
GA 300OC
UT WOS:000255832800018
PM 18479286
OA gold
DA 2025-06-11
ER

PT J
AU Lim, A
   Pasini, M
   Yun, SJ
   Gill, J
   Koirala, B
AF Lim, Arum
   Pasini, Mia
   Yun, Sijung
   Gill, Jessica
   Koirala, Binu
TI Genetic association between post-traumatic stress disorder and
   cardiovascular disease: A scoping review
SO JOURNAL OF PSYCHIATRIC RESEARCH
LA English
DT Review
DE Post-traumatic stress disorder; Cardiovascular disease; Genes; Genetic
   association; Scoping review
ID POLYGENIC RISK; PTSD; EPIDEMIOLOGY; ALCOHOL; EXPRESSION; REACTIVITY;
   GENOTYPE; HEALTH; COHORT
AB Introduction: Post-traumatic stress disorder (PTSD) is a complex psychiatric disorder associated with adverse long-term health outcomes, including cardiovascular disease (CVD). Despite growing evidence that PTSD is positively associated with CVD, the biological mechanisms underlying this association are poorly understood. This review provides an overview of the current state of science on the genetic association between PTSD and CVD. Material and methods: This scoping review identified studies from Pubmed, Embase, PsycINFO, and Web of Science. The search terms were a combination of PTSD, CVD/CVD-related traits, and a set of genetic molecules and related terms. This review followed the PRISMA Extension for Scoping Reviews guidelines. Eligible criteria included original studies that have genetic factors related to PTSD or CVD, conducted in humans, written in English, and published between 2003 and 2023 in peer-reviewed journals. Results: A total of twenty-three studies were included; PTSD correlated with genetic variants in CVD-related traits and gene expression in regulatory pathways contributing to CVD development. Common CVD-related traits involved in genetic associations with PTSD were inflammation, cellular aging, increased blood pressure, hypothalamus-pituitary-adrenal axis dysregulation, metabolic syndrome, and oxidative stress. These traits may explain potential underlying mechanisms between PTSD and CVD. Evidence of a causal relationship between the two diseases was insufficient. Discussion: PTSD and CVD/CVD-related traits are genetically associated. Further research is needed to comprehensively explore gene-environment interactions and the cumulative impact of behavioral and psychological factors on the pathophysiological mechanisms between PTSD and CVD.
C1 [Lim, Arum; Pasini, Mia; Yun, Sijung; Gill, Jessica; Koirala, Binu] Johns Hopkins Sch Nursing, 525 N Wolfe St, Baltimore, MD USA.
   [Lim, Arum] Johns Hopkins Univ, Sch Nursing, 525 N Wolfe St, Baltimore, MD 21205 USA.
C3 Johns Hopkins University; Johns Hopkins University
RP Lim, A (corresponding author), Johns Hopkins Univ, Sch Nursing, 525 N Wolfe St, Baltimore, MD 21205 USA.
EM alim19@jh.edu
OI Lim, Arum/0000-0002-5220-5249
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NR 78
TC 1
Z9 1
U1 2
U2 5
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-3956
EI 1879-1379
J9 J PSYCHIATR RES
JI J. Psychiatr. Res.
PD OCT
PY 2024
VL 178
BP 331
EP 348
DI 10.1016/j.jpsychires.2024.08.027
EA AUG 2024
PG 18
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA E3H7Y
UT WOS:001301951500001
PM 39191203
DA 2025-06-11
ER

PT J
AU Ramos, AR
   Wallace, DM
   Pandi-Perumal, SR
   Williams, NJ
   Castor, C
   Sevick, MA
   Mcfarlane, SI
   Jean-Louis, G
AF Ramos, Alberto R.
   Wallace, Douglas M.
   Pandi-Perumal, Seithikurippu Ratnas
   Williams, Natasha J.
   Castor, Chimene
   Sevick, Mary Ann
   Mcfarlane, Samy I.
   Jean-Louis, Girardin
TI Associations between sleep disturbances and diabetes mellitus among
   blacks with metabolic syndrome: Results from the Metabolic Syndrome
   Outcome Study (MetSO)
SO ANNALS OF MEDICINE
LA English
DT Article
DE Black race/ethnicity; diabetes mellitus; metabolic syndrome; sleep apnea
ID INSULIN-RESISTANCE; RACIAL-DIFFERENCES; AFRICAN-AMERICANS; DURATION;
   APNEA; INDIVIDUALS; DISPARITIES; POPULATION; PREVALENCE; GLUCOSE
AB Introduction. The association between sleep disturbances and cardiometabolic diseases has been understudied in blacks with metabolic syndrome.
   Methods. This study is a cross-sectional analysis of the Metabolic Syndrome Outcome Study (MetSO) trial. We assessed insomnia symptoms, sleep duration, and risk for sleep apnea. Multivariate logistic regression models evaluated the association between sleep disturbances with diabetes mellitus (DM) and the combined outcomes of DM and hypertension as well as DM and dyslipidemia.
   Results. The sample consisted of 1,013 participants, mean age of 62 +/- 14 years and 61% female. DM was diagnosed in 60% of the sample. Sleep apnea risk was observed in 48% of the sample, while 10% had insomnia symptoms and 65% reported short sleep duration (<6 hours). Sleep apnea risk, but not insomnia or sleep duration, was associated with DM (OR 1.66; 95% CI 1.21-2.28), adjusting for age, sex, income, obesity (BMI >= 30 kg/m(2)), tobacco use, alcohol use, hypertension, dyslipidemia, and depression. In fully adjusted models, sleep apnea risk was associated with the combined outcome of DM-hypertension (OR 1.95; 95% CI 1.42-2.69), but not with diabetes-dyslipidemia.
   Conclusion. We observed a strong association between sleep apnea risk and diabetes mellitus among blacks with metabolic syndrome.
C1 [Ramos, Alberto R.; Wallace, Douglas M.] Univ Miami, Miller Sch Med, Dept Neurol, Miami, FL 33136 USA.
   [Pandi-Perumal, Seithikurippu Ratnas; Williams, Natasha J.; Sevick, Mary Ann; Jean-Louis, Girardin] NYU, CHBC, Div Hlth & Behav, Dept Populat Hlth,Langone Med Ctr, New York, NY USA.
   [Castor, Chimene] Howard Univ, Dept Nutr Sci, Washington, DC 20059 USA.
   [Mcfarlane, Samy I.] Suny Downstate Med Ctr, Dept Med, New York, NY USA.
C3 University of Miami; New York University; NYU Langone Medical Center;
   Howard University; State University of New York (SUNY) System; SUNY
   Downstate Health Sciences University
RP Ramos, AR (corresponding author), Univ Miami, Miller Sch Med, UHlth Sleep Med Program, Miami, FL 33136 USA.
EM aramos@med.miami.edu
RI Sevick, Mary/V-6503-2019; Ramos, Alberto/X-4249-2019; Wallace,
   Douglas/AAL-3719-2020; Pandi-Perumal, Seithikurippu/Q-8281-2016;
   Pandi-Perumal, Seithikurippu R/C-6767-2008
OI Ramos, Alberto/0000-0002-9861-6609; Pandi-Perumal, Seithikurippu
   R/0000-0002-8686-7259; Wallace, Douglas/0000-0002-8982-1088; Jean-Louis,
   Girardin/0000-0001-6777-2724
FU National Institutes of Health [R01MD004113, 1KL2TR000461, NCT01946659]
FX The authors sincerely acknowledge the financial support received from
   National Institutes of Health R01MD004113, 1KL2TR000461 (A.R.R.),
   NCT01946659.
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NR 32
TC 16
Z9 16
U1 0
U2 13
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0785-3890
EI 1365-2060
J9 ANN MED
JI Ann. Med.
PD MAY
PY 2015
VL 47
IS 3
BP 233
EP 237
DI 10.3109/07853890.2015.1015601
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA CJ5WD
UT WOS:000355562200006
PM 25856540
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Liu, MM
   Li, SY
   Guan, MY
   Bai, S
   Bai, WB
   Jiang, XW
AF Liu, Maomao
   Li, Siyu
   Guan, Meiyi
   Bai, Shun
   Bai, Weibin
   Jiang, Xinwei
TI Leptin pathway is a crucial target for anthocyanins to protect against
   metabolic syndrome
SO CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
LA English
DT Review
DE Anthocyanin; leptin resistance; metabolic syndrome; metabolic disorder;
   insulin resistance
ID DIET-INDUCED OBESITY; GENE-EXPRESSION; INSULIN-RESISTANCE;
   ADIPOSE-TISSUE; HEPG2 CELLS; OXIDATIVE STRESS; PREVENTS OBESITY;
   BODY-WEIGHT; PPAR-GAMMA; GLUCOSE
AB The high prevalence of metabolic syndrome is threatening the health of populations all over the world. Contemporary work demonstrates that high leptin concentration is directly related to the development of metabolic syndrome such as obesity, fatty liver diseases, type 2 diabetes mellitus and cardiovascular diseases. Anthocyanins are a widespread group of dietary polyphenols, which can ameliorate chronic diseases related to metabolic syndrome. In addition, anthocyanins can regulate the leptin pathway in chronic metabolic diseases, however the potential mechanism between anthocyanin and leptin is complex and elusive. In this review paper, we have evaluated the bioactivity of anthocyanins on the mediation of leptin level and the upstream and downstream pathways in chronic metabolic diseases. Anthocyanins could regulate the hypertrophy of adipose tissue, and the expression of leptin level via mediating TNF-alpha, C/EBP, PPAR, CREB and SREBP-1. Anthocyanins promoted the leptin sensitivity by increasing the level of leptin receptor, phosphorylation of JAK2/STAT3, PI3K/AKT, and additionally ameliorated metabolic disorder related outcome, including oxidative stress, inflammation, lipid accumulation, insulin resistance and the balance of gut microbiota. However, direct evidence of anthocyanins treatment on leptin signal transduction is still limited which calls for future molecular binding and gene regulation test.
C1 [Liu, Maomao; Li, Siyu; Bai, Weibin; Jiang, Xinwei] Jinan Univ, Inst Food Safety & Nutr, Dept Food Sci & Engn, Guangzhou, Peoples R China.
   [Guan, Meiyi] Jinan Univ, Int Sch, Dept Food Sci & Engn, Guangzhou, Peoples R China.
   [Bai, Shun] Univ Sci & Technol China, Reprod & Genet Hosp, Affiliated Hosp USTC 1, Div Life Sci & Med, Hefei, Peoples R China.
C3 Jinan University; Jinan University; Chinese Academy of Sciences;
   University of Science & Technology of China, CAS
RP Bai, WB; Jiang, XW (corresponding author), Jinan Univ, Inst Food Safety & Nutr, Dept Food Sci & Engn, Guangzhou, Peoples R China.
EM baiweibin@163.com; haiyuanjxw@126.com
RI Liu, Maomao/JFJ-0451-2023
FU Special Project for Research and Development in Key areas of Guangdong
   Province [2022B0202040001]; Science and Technology Projects in Guangzhou
   [202201010504]; National Natural Science Foundation of China [U22A20546]
FX This study is supported by the Special Project for Research and
   Development in Key areas of Guangdong Province [No. 2022B0202040001] and
   Science and Technology Projects in Guangzhou [202201010504]. The authors
   also thank the National Natural Science Foundation of China [No.
   U22A20546].
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NR 168
TC 4
Z9 4
U1 6
U2 35
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1040-8398
EI 1549-7852
J9 CRIT REV FOOD SCI
JI Crit. Rev. Food Sci. Nutr.
PD APR 20
PY 2025
VL 65
IS 11
BP 2046
EP 2061
DI 10.1080/10408398.2024.2323093
EA FEB 2024
PG 16
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA 1AQ0H
UT WOS:001196624400001
PM 38567995
DA 2025-06-11
ER

PT J
AU Chan, KY
   Wong, MMH
   Pang, SSH
   Lo, KKH
AF Chan, Kwan Yi
   Wong, Martin Ming Him
   Pang, Sally Shuk Han
   Lo, Kenneth Ka Hei
TI Dietary supplementation for gestational diabetes prevention and
   management: a meta-analysis of randomized controlled trials
SO ARCHIVES OF GYNECOLOGY AND OBSTETRICS
LA English
DT Review
DE Dietary supplements; Gestational diabetes; Randomized controlled trials;
   Meta-analysis
ID VITAMIN-D SUPPLEMENTATION; OXIDATIVE STRESS; GLUCOSE-METABOLISM;
   INSULIN-RESISTANCE; LIPID PROFILES; DOUBLE-BLIND; MYOINOSITOL
   SUPPLEMENTATION; PREGNANCY OUTCOMES; CO-SUPPLEMENTATION; MELLITUS
AB Purpose The use of supplement to prevent and ease gestational diabetes (GDM) progression has been examined in various studies, but the results were inconclusive, and studies evaluated dietary supplements separately. The present review aimed to evaluate the efficacy of various dietary supplementation on GDM risk and the surrogate markers for cardiometabolic risk of pregnant women with GDM. Methods A comprehensive search on multiple databases were performed to identify randomized controlled trials. Random-effects model was used to pool the results in relative risk (RR) or mean difference. Results Fifty-three randomized controlled studies with 9443 pregnant women were included. Vitamin D (5 studies, RR 0.64; 95% CI 0.44, 0.94) and myo-inositol (4 studies, RR 0.34, 95% CI 0.20, 0.58) supplementation significantly reduced the risk of GDM. Myo-inositol, probiotics, and vitamin D showed significant intervention effect on surrogate markers related to glycemic control, lipid profile, inflammatory, and oxidative stress. However, the majority of included studies were clustered to Iran and Italy, which might convey a generalizability bias. Conclusion Dietary supplementation including vitamin D and myoinositol supplementation has the potential in primary prevention and management of GDM, whereas probiotics demonstrated its ability in GDM management by improving the levels of surrogate markers for cardiometabolic risk. The potential for dietary supplement in preventing GDM or managing cardiometabolic risk of pregnant women should receive more attentions.
C1 [Chan, Kwan Yi] Chinese Univ Hong Kong, Sch Publ Hlth & Primary Care, Shatin, Hong Kong, Peoples R China.
   [Wong, Martin Ming Him] Univ Hong Kong, Sch Profess & Continuing Educ, Hong Kong, Peoples R China.
   [Pang, Sally Shuk Han] Univ Hong Kong, Fac Sci, Sch Biol Sci, Hong Kong, Peoples R China.
   [Lo, Kenneth Ka Hei] Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Hung Hom, Kowloon, 11 Yuk Choi Rd, Hong Kong, Peoples R China.
C3 Chinese University of Hong Kong; University of Hong Kong; University of
   Hong Kong; Hong Kong Polytechnic University
RP Lo, KKH (corresponding author), Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Hung Hom, Kowloon, 11 Yuk Choi Rd, Hong Kong, Peoples R China.
EM khklo@polyu.edu.hk
RI Lo, Kenneth/ABB-6248-2020; , Kenneth/C-6537-2014
OI , Kenneth/0000-0003-4624-2737
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NR 52
TC 28
Z9 28
U1 3
U2 22
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0932-0067
EI 1432-0711
J9 ARCH GYNECOL OBSTET
JI Arch. Gynecol. Obstet.
PD JUN
PY 2021
VL 303
IS 6
BP 1381
EP 1391
DI 10.1007/s00404-021-06023-9
EA MAR 2021
PG 11
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA RV6DI
UT WOS:000630979600001
PM 33745021
DA 2025-06-11
ER

PT J
AU Ibrahim, KG
   Adeshina, KA
   Bello, MB
   Malami, I
   Abubakar, B
   Abubakar, MB
   Imam, MU
AF Ibrahim, Kasimu Ghandi
   Adeshina, Kehinde Ahmad
   Bello, Muhammad Bashir
   Malami, Ibrahim
   Abubakar, Bilyaminu
   Abubakar, Murtala Bello
   Imam, Mustapha Umar
TI Prophylactic Use of Natural Products against Developmentally Programmed
   Metabolic Syndrome
SO PLANTA MEDICA
LA English
DT Review
DE developmental programing; neonatal; metabolic syndrome; phytochemicals;
   plant extracts
ID HIGH-FAT DIET; HIGH-FRUCTOSE DIET; ACTIVATED PROTEIN-KINASE;
   LOW-BIRTH-WEIGHT; OXIDATIVE STRESS; INSULIN-RESISTANCE; GUT MICROBIOTA;
   LIVER-DISEASE; EPIGENETIC REGULATION; LIPID-METABOLISM
AB Parental dietary choices and/or nutritional interventions in the offspring are critical to early life development, especially during the periods of active developmental plasticity in the offspring. Exposure to a high-fructose, high-fat diet during the fetal or neonatal period predisposes the affected individuals to the development of one or more features of metabolic syndrome, such as dyslipidemia, insulin resistance, diabetes, and associated cardiovascular diseases, later in their life. Owing to the increasing global prevalence of metabolic syndrome and multiple side effects that accompany conventional medicines, much attention is directed towards medicinal plants and phytochemicals as alternative interventions. Several studies have investigated the potential of natural agents to prevent programmed metabolic syndrome. This present review, therefore, highlights an inextricable relationship between the administration of medicinal plants or phytochemicals during the intrauterine or neonatal period, and the prevention of metabolic dysfunction in adulthood, while exploring the mechanisms by which they exert such an effect. The review also identifies plant products as a novel approach to the prevention and management of metabolic syndrome.
C1 [Ibrahim, Kasimu Ghandi; Adeshina, Kehinde Ahmad; Abubakar, Murtala Bello] Usmanu Danfodiyo Univ, Dept Physiol, Coll Hlth Sci, Fac Basic Med Sci, Hosp Rd,PMB 2254, Sokoto 840232, Nigeria.
   [Ibrahim, Kasimu Ghandi; Adeshina, Kehinde Ahmad; Bello, Muhammad Bashir; Malami, Ibrahim; Abubakar, Bilyaminu; Abubakar, Murtala Bello; Imam, Mustapha Umar] Usmanu Danfodiyo Univ, Ctr Adv Med Res & Training, Sokoto, Nigeria.
   [Bello, Muhammad Bashir] Usmanu Danfodiyo Univ, Dept Vet Microbiol, Fac Vet Med, Sokoto, Nigeria.
   [Malami, Ibrahim] Usmanu Danfodiyo Univ, Fac Pharmaceut Sci, Dept Pharmacognosy & Ethnopharm, Sokoto, Nigeria.
   [Abubakar, Bilyaminu] Usmanu Danfodiyo Univ, Fac Pharmaceut Sci, Dept Pharmacol & Toxicol, Sokoto, Nigeria.
   [Imam, Mustapha Umar] Usmanu Danfodiyo Univ, Dept Med Biochem, Coll Hlth Sci, Fac Basic Med Sci, Sokoto, Nigeria.
RP Ibrahim, KG (corresponding author), Usmanu Danfodiyo Univ, Dept Physiol, Coll Hlth Sci, Fac Basic Med Sci, Hosp Rd,PMB 2254, Sokoto 840232, Nigeria.
EM ghandi.kasimu@udusok.edu.ng
RI Abubakar, Murtala/G-8964-2016; Malami, Ibrahim/C-4513-2019; Abubakar,
   Bilyaminu/AAC-5821-2019; Bello, Muhammad Bashir/AAZ-9569-2020; Imam,
   Mustapha/K-3490-2012; Ghandi, Kasimu/L-7904-2017
OI Ghandi, Kasimu/0000-0002-2119-580X; Imam, Mustapha
   Umar/0000-0001-9888-4809; Adeshina, Kehinde Ahmad/0000-0002-6403-0626
FU CAMRET [CAMRET/2019/MSc/SCH002]; Institution-Based Research (IBR) grant
   of the Tertiary Education Trust Fund (TETFUND) of Nigeria
FX The scholars and staff of the Centre for Advanced Medical Research and
   Training (CAMRET) are highly appreciated for their various contributions
   to the success of this paper. Kehinde Ahmad Adeshina is a recipient of a
   CAMRET research funded scholarship (CAMRET/2019/MSc/SCH002). This study
   was supported by the Institution-Based Research (IBR) grant of the
   Tertiary Education Trust Fund (TETFUND) of Nigeria awarded to Usmanu
   Danfodiyo University Sokoto (TETFUND/DR&D/CE/UNIV/SOKOTO/RP/VOL.1).
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NR 112
TC 4
Z9 4
U1 0
U2 6
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0032-0943
EI 1439-0221
J9 PLANTA MED
JI Planta Med.
PD JUL
PY 2022
VL 88
IS 08
BP 650
EP 663
DI 10.1055/a-1482-2343
EA MAY 2021
PG 14
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA 2S2UT
UT WOS:000651188300001
PM 34000739
OA Bronze
DA 2025-06-11
ER

PT J
AU Mulders, RJ
   de Git, KCG
   Schéle, E
   Dickson, SL
   Sanz, Y
   Adan, RAH
AF Mulders, R. J.
   de Git, K. C. G.
   Schele, E.
   Dickson, S. L.
   Sanz, Y.
   Adan, R. A. H.
TI Microbiota in obesity: interactions with enteroendocrine, immune and
   central nervous systems
SO OBESITY REVIEWS
LA English
DT Article
DE hypothalamus; inflammation; microbiota; obesity
ID HIGH-FAT-DIET; Y GASTRIC BYPASS; GUT MICROBIOTA; INSULIN-RESISTANCE;
   AKKERMANSIA-MUCINIPHILA; INTESTINAL MICROBIOTA; WEIGHT-GAIN;
   PSYCHOLOGICAL STRESS; METABOLIC SYNDROME; BODY-WEIGHT
AB Western diets, with high consumption of simple sugars and saturated fats, contribute to the rise in the prevalence of obesity. It now seems clear that high-fat diets cause obesity, at least in part, by modifying the composition and function of the microorganisms that colonize in the gastrointestinal tract, the microbiota. The exact pathways by which intestinal microbiota contribute to obesity remain largely unknown. High-fat diet-induced alterations in intestinal microbiota have been suggested to increase energy extraction, intestinal permeability and systemic inflammation while decreasing the capability to generate obesity-suppressing short-chain fatty acids. Moreover, by increasing systemic inflammation, microglial activation and affecting vagal nerve activity, obese microbiota' indirectly influence hypothalamic gene expression and promote overeating. Because the potential of intestinal microbiota to induce obesity has been recognized, multiple ways to modify its composition and function are being investigated to provide novel preventive and therapeutic strategies against diet-induced obesity.
C1 [Mulders, R. J.] Univ Utrecht, Masters Programme Sci & Business Management, Utrecht, Netherlands.
   [de Git, K. C. G.; Adan, R. A. H.] Univ Utrecht, Univ Med Ctr Utrecht, Brain Ctr Rudolf Magnus, Dept Translat Neurosci, Univ Weg 100, NL-3584 CG Utrecht, Netherlands.
   [Schele, E.; Dickson, S. L.] Univ Gothenburg, Sahlgrenska Acad, Inst Neurosci & Physiol, Gothenburg, Sweden.
   [Sanz, Y.] CSIC, Natl Res Council, Inst Agrochemistry & Food Technol, Microbial Ecol Nutr & Hlth Res Grp,IATA, Valencia, Spain.
C3 Utrecht University; Utrecht University; Utrecht University Medical
   Center; University of Gothenburg; Consejo Superior de Investigaciones
   Cientificas (CSIC); Instituto de Agroquimica y Tecnologia de los
   Alimentos (IATA)
RP Adan, RAH (corresponding author), Univ Utrecht, Univ Med Ctr Utrecht, Brain Ctr Rudolf Magnus, Dept Translat Neurosci, Univ Weg 100, NL-3584 CG Utrecht, Netherlands.
EM r.a.h.adan@umcutrecht.nl
RI Dickson, Suzanne/U-4628-2019; Sanz, Yolanda/H-5498-2012
OI Sanz, Yolanda/0000-0002-1615-1976
FU European Union [613979, 607310]; Spanish Ministry of Economy and
   Competitiveness (MINECO) [AGL2014-52101-P]; Swedish Research Council for
   Medicine (Vetenskapsradet) [2016-20195]; Dutch STW; European College for
   Neuropsychopharmacology (the Nutrition Network)
FX This work was supported by the European Union's Seventh Framework
   Program under grant agreements 613979 (MyNewGut to YS) and 607310
   (Nudge-it, to RA and SD), by the Spanish Ministry of Economy and
   Competitiveness (MINECO, grant AGL2014-52101-P to YS), by the Swedish
   Research Council for Medicine (Vetenskapsradet, grant number 2016-20195
   to SD) and by the Dutch STW. We also acknowledge support from the
   European College for Neuropsychopharmacology (the Nutrition Network).
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NR 188
TC 83
Z9 91
U1 2
U2 131
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1467-7881
EI 1467-789X
J9 OBES REV
JI Obes. Rev.
PD APR
PY 2018
VL 19
IS 4
BP 435
EP 451
DI 10.1111/obr.12661
PG 17
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA FY2MZ
UT WOS:000426651300001
PM 29363272
DA 2025-06-11
ER

PT J
AU Karamali, M
   Bahramimoghadam, S
   Sharifzadeh, F
   Asemi, Z
AF Karamali, Maryam
   Bahramimoghadam, Shahla
   Sharifzadeh, Fateme
   Asemi, Zatollah
TI RETRACTED: Magnesium-zinc-calcium-vitamin D co-supplementation improves
   glycemic control and markers of cardiometabolic risk in gestational
   diabetes: a randomized, double-blind, placebo-controlled trial
   (Retracted article. See vol. 50, 2025)
SO APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
LA English
DT Article; Retracted Publication
DE supplementation; gestational diabetes mellitus; glycemic control;
   cardiometabolic risk
ID D-DEFICIENT WOMEN; OXIDATIVE STRESS; INSULIN SENSITIVITY; PREGNANCY
   OUTCOMES; METABOLIC STATUS; LIPID PROFILE; INFLAMMATION; OVERWEIGHT;
   GLUCOSE; WEIGHT
AB To the best our knowledge, data on the effects of magnesium-zinc-calcium-vitamin D co-supplementation on glycemic control and markers of cardiometabolic risk in gestational diabetes mellitus (GDM) are scarce. The purpose of this study was to establish the effects of magnesium-zinc-calcium-vitamin D co-supplementation on glycemic control and markers of cardiometabolic risk of GDM patients. Sixty patients with GDM, aged 18-40 years, were randomized into 2 groups to intake either magnesium-zinc-calcium-vitamin D co-supplements or placebo (n = 30 each group) for 6 weeks in a randomized, double-blind, placebo-controlled trial. Fasting blood samples were taken at baseline and week 6 to quantify related markers. After the 6-week intervention, compared with the placebo, magnesium-zinc-calcium-vitamin D co-supplementation resulted in significant reductions in fasting plasma glucose (-0.37 +/- 0.09 vs. + 0.01 +/- 0.09 mmol/L, P = 0.003), serum insulin levels (-21.0 +/- 4.8 vs. + 7.2 +/- 4.8 pmol/L, P < 0.001), homeostatic model of assessment for insulin resistance (-1.0 +/- 1.1 vs. + 0.3 +/- 1.3, P < 0.001), and a significant increase in quantitative insulin sensitivity check index (+ 0.02 +/- 0.03 vs. -0.002 +/- 0.03, P = 0.003). In addition, magnesium-zinc-calcium-vitamin D co-supplementation significantly decreased serum triglycerides (-0.25 +/- 0.10 vs. + 0.34 +/- 0.10 mmol/L, P = 0.001) and very-low-density-cholesterol concentrations (-0.11 +/- 0.04 vs. + 0.15 +/- 0.04 mmol/L, P = 0.001) compared with the placebo. Overall, the results of this study demonstrated that magnesium-zinc-calcium-vitamin D co-supplementation for 6 weeks among patients with GDM had beneficial effects on glycemic control and few markers of cardiometabolic risk.
C1 [Karamali, Maryam; Bahramimoghadam, Shahla; Sharifzadeh, Fateme] Iran Univ Med Sci, Sch Med, Dept Gynecol & Obstet, Tehran, Iran.
   [Asemi, Zatollah] Kashan Univ Med Sci, Res Ctr Biochem & Nutr Metab Dis, Kashan, Iran.
   [Asemi, Zatollah] Kashan Univ Med Sci, Dept Nutr, Kashan, Iran.
C3 Iran University of Medical Sciences
RP Asemi, Z (corresponding author), Kashan Univ Med Sci, Res Ctr Biochem & Nutr Metab Dis, Kashan, Iran.; Asemi, Z (corresponding author), Kashan Univ Med Sci, Dept Nutr, Kashan, Iran.
EM asemi_r@yahoo.com
RI asemi, zatollah/J-2677-2018
FU IUMS, and Iran
FX The present study was supported by a grant from the Vice-chancellor for
   Research, IUMS, and Iran. Authors' contributions: Z.A. contributed in
   conception, design, statistical analysis, and drafting of the
   manuscript. M.K., S.B., and F.B. contributed in conception, data
   collection, and manuscript drafting. The final version was confirmed by
   all authors for submission.
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NR 41
TC 34
Z9 38
U1 0
U2 30
PU CANADIAN SCIENCE PUBLISHING
PI OTTAWA
PA 123 Slater Street, Suite 610, OTTAWA, ON K1P 5H2, CANADA
SN 1715-5312
EI 1715-5320
J9 APPL PHYSIOL NUTR ME
JI Appl. Physiol. Nutr. Metab.
PD JUN
PY 2018
VL 43
IS 6
BP 565
EP 570
DI 10.1139/apnm-2017-0521
PG 6
WC Nutrition & Dietetics; Physiology; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics; Physiology; Sport Sciences
GA GH6JL
UT WOS:000433550300004
PM 29316405
DA 2025-06-11
ER

PT J
AU Eroglu, S
   Sade, LE
   Yildirir, A
   Demir, O
   Bozbas, H
   Muderrisoglu, H
AF Eroglu, Serpil
   Sade, Leyla Elif
   Yildirir, Aylin
   Demir, Ozlem
   Bozbas, Huseyin
   Muderrisoglu, Haldun
TI Serum levels of C-reactive protein and uric acid in patients with
   cardiac syndrome X
SO ACTA CARDIOLOGICA
LA English
DT Article
DE C-reactive protein; uric acid; syndrome X
ID CORONARY-HEART-DISEASE; ENDOTHELIAL DYSFUNCTION; CARDIOVASCULAR-DISEASE;
   METABOLIC SYNDROME; INSULIN-RESISTANCE; RISK-FACTORS; INFLAMMATION;
   ATHEROSCLEROSIS; ARTERIOGRAMS; PATHOPHYSIOLOGY
AB Objectives - Angina-like chest pain, a positive result from a stress test, and normal coronary arteries are characteristics of patients with cardiac syndrome X (CSX). Serum levels of C-reactive protein (CRP), which is a marker of a systemic inflammatory state, are associated with coronary atherosclerosis and endothelial dysfunction. Serum uric acid (UA) levels have also been implicated in the development of atherosclerotic cardiovascular disease. However, little is known about the association of serum UA and CRIP levels with CSX.
   Methods - In all, 250 subjects (100 patients with CSX, 100 with coronary artery disease (CAD), and 50 control subjects) were enrolled in the study. Coronary arteries were evaluated by conventional coronary angiography in the CSX and CAD groups. All patients underwent a noninvasive stress test. To determine whether they are potential risk factors for CSX, serum CRP and UA levels were compared among the 3 groups.
   Results - Serum levels of CRP were higher in patients with CSX or CAD than in the control subjects (4.4 +/- 3.1 and 4.5 +/- 2.9 mg/L, respectively, vs. 1.9 +/- 1.6 mg/L; P < 0.001), but those levels were similar in patients with CSX or CAD. Uric acid levels were higher in patients with CSX or CAD than in the control subjects (5.5 +/- 1.1 mg/dl and 5.9 +/- 1.4 mg/dl, respectively, vs. 4.4 +/- 1.2 mg/dl; P < 0.001), but those levels were also similar in patients with CSX or CAD.
   Conclusions - In patients with CSX, serum CRIP and UA levels were as high as those in patients with CAD. Elevated serum CRP and UA levels may contribute to the development of CSX.
C1 [Eroglu, Serpil; Sade, Leyla Elif; Yildirir, Aylin; Demir, Ozlem; Bozbas, Huseyin; Muderrisoglu, Haldun] Baskent Univ, Fac Med, Dept Cardiol, TR-06490 Ankara, Turkey.
C3 Baskent University
RP Eroglu, S (corresponding author), Baskent Univ Hastanesi, Maresal Fevzi Cakmak Cad 10,Sok 45, TR-06490 Ankara, Turkey.
EM serpileroglu@gmail.com
RI Eroglu, Serpil/ABG-1582-2021; Sade, Leyla Elif/AAQ-7583-2021; YILDIRIR,
   Aylin/A-4947-2018; MUDERRISOGLU, IBRAHIM HALDUN/AAG-8233-2020
OI Sade, Leyla Elif/0000-0003-3737-8595; Eroglu,
   Serpil/0000-0003-3055-7953; YILDIRIR, Aylin/0000-0001-8750-5287;
   MUDERRISOGLU, IBRAHIM HALDUN/0000-0002-9635-6313
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NR 33
TC 12
Z9 14
U1 0
U2 3
PU ACTA CARDIOLOGICA
PI BRUSSELS
PA AVENUE CIRCULAIRE 138A, 1180 BRUSSELS, BELGIUM
SN 0001-5385
J9 ACTA CARDIOL
JI Acta Cardiol.
PD APR
PY 2009
VL 64
IS 2
BP 207
EP 211
DI 10.2143/AC.64.2.2036139
PG 5
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 437IJ
UT WOS:000265480200009
PM 19476113
DA 2025-06-11
ER

PT J
AU Carraro, A
   Gobbi, E
   Solmi, M
   Watkins, A
   Ward, PB
   Rosenbaum, S
AF Carraro, Attilio
   Gobbi, Erica
   Solmi, Marco
   Watkins, Andrew
   Ward, Philip B.
   Rosenbaum, Simon
TI Test-retest reliability of the Italian version of the M-BACK
   questionnaire to assess the barriers, attitudes, confidence, and
   knowledge of mental health staff regarding metabolic health of
   psychiatric patients
SO BRAIN AND BEHAVIOR
LA English
DT Article
DE evaluation tool; metabolic syndrome; physical health; reliability;
   severe mental illness
ID ILLNESS; PEOPLE; DISORDERS; MORTALITY; PREVALENCE; NEEDS; RISK;
   SCHIZOPHRENIA; INTERVENTION; ADDRESS
AB Objectives The Metabolic-Barriers, Attitudes, Confidence, and Knowledge Questionnaire (M-BACK) was developed to determine the barriers, attitudes, confidence, and knowledge of mental health practitioners regarding the metabolic health of patients in order to determine the efficacy of targeted training interventions. This study aimed to validate the Italian version of M-BACK questionnaire (M-BACK-IT) and to determine the test-retest reliability. Methods The M-BACK questionnaire was translated into Italian and back-translated using an established protocol. In order to determine the test-retest reliability of the instrument, mental health professionals were recruited from a private psychiatric hospital located in northeast Italy and completed the questionnaire on two separate occasions, seven days apart. Intraclass correlation coefficients (ICC) were calculated for the total score, as well as each of the four M-BACK domains. Results Thirty mental health professionals (4 psychiatrists, 9 psychologists, 12 nurses, and 5 exercise specialists) completed the M-BACK-IT. ICCs ranged from 0.58 to 0.94. Conclusions The test-retest reliability of the M-BACK-IT demonstrated comparable results to the English version. The M-BACK-IT is a reliable measure to assess key elements of practitioners' perceptions of the barriers, their knowledge, attitudes, and confidence regarding metabolic monitoring and intervention in people with mental illness.
C1 [Carraro, Attilio] Free Univ Bozen, Fac Educ, Bolzano, Italy.
   [Carraro, Attilio] Casa Cura Parco Tigli, Padua, Italy.
   [Gobbi, Erica] Univ Padua, Dept Biomed Sci, Padua, Italy.
   [Solmi, Marco] Univ Padua, Dept Neurosci, Padua, Italy.
   [Watkins, Andrew] South Eastern Sydney Local Hlth Dist, Bondi Ctr, Keeping Body Mind Program, Sydney, NSW, Australia.
   [Watkins, Andrew] Univ Technol Sydney, Fac Hlth, Sydney, NSW, Australia.
   [Ward, Philip B.; Rosenbaum, Simon] Univ New South Wales, Sch Psychiat, Sydney, NSW, Australia.
   [Ward, Philip B.] South Western Sydney Local Hlth Dist, Liverpool Hosp, Ingham Inst Appl Med Res, Schizophrenia Res Unit, Sydney, NSW, Australia.
   [Rosenbaum, Simon] Prince Wales Hosp, Black Dog Inst, Sydney, NSW, Australia.
C3 Free University of Bozen-Bolzano; University of Padua; University of
   Padua; South Eastern Sydney Local Health District; University of
   Technology Sydney; University of New South Wales Sydney; South Western
   Sydney Local Health District; Liverpool Hospital; Ingham Institute for
   Applied Medical Research; University of New South Wales Sydney; Prince
   of Wales Hospital (POWH); Black Dog Institute
RP Carraro, A (corresponding author), Free Univ Bozen, Fac Educ, Viale Ratisbona 16, I-39042 Brixen, BZ, Italy.
EM attilio.carraro@unibz.it
RI Gobbi, Erica/AAA-8602-2020; Carraro, Attilio/AAD-1762-2020; Rosenbaum,
   Simon/Y-3241-2019; solmi, marco/K-3906-2018; Ward, Philip/JCE-6293-2023
OI solmi, marco/0000-0003-4877-7233; Ward, Philip/0000-0002-5779-7722;
   Rosenbaum, Simon/0000-0002-8984-4941; Watkins,
   Andrew/0000-0003-3452-8682
FU NHMRC Early Career Fellowship [APP1123336]; University of Padua; Free
   University of Bozen-Bolzano
FX NHMRC Early Career Fellowship, Grant/Award Number: APP1123336;
   University of Padua; Free University of Bozen-Bolzano
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NR 27
TC 1
Z9 1
U1 0
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 2162-3279
J9 BRAIN BEHAV
JI Brain Behav.
PD FEB
PY 2020
VL 10
IS 2
AR e01491
DI 10.1002/brb3.1491
EA DEC 2019
PG 6
WC Behavioral Sciences; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Behavioral Sciences; Neurosciences & Neurology
GA KM7TF
UT WOS:000504184400001
PM 31875357
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Enkhtur, A
   Yoon, JS
   Lee, CW
AF Enkhtur, Altansuvd
   Yoon, Joon-Sup
   Lee, Chang-Woo
TI Factors increasing the risk of mortality and morbidity due to
   coronavirus infection in patients with metabolic syndrome
SO PRECISION AND FUTURE MEDICINE
LA English
DT Review
DE COVID-19; Inflammation; JAK kinases; Metabolic syndrome; STAT
   transcription factors
ID NF-KAPPA-B; ENDOPLASMIC-RETICULUM STRESS; INSULIN-RESISTANCE; LEPTIN
   RESISTANCE; IMPAIRS LIPOLYSIS; ER STRESS; INFLAMMATION; OBESITY;
   INFLUENZA; MICE
AB Patients living with comorbid metabolic syndrome (MS) and metabolic disorders such as obesity and type 2 diabetes mellitus carry increased levels of circulating cytokines and systemic low-grade inflammation. Upon viral infection, such patients with all pre-existing backgrounds, specifically dysregulated inflammatory signalling, leads to rapid viral replication and results in worse clinical outcomes. The increased pro-inflammatory cytokine release is a risk factor, and therefore, targeting inflammatory signalling pathways represents a potential therapeutic target to control the cytokine release, and thereby prevent serious outcomes, such as increased mortality and morbidity. In this review, we elucidate the factors underlying the increased morbidity and mortality in patients with MS and virus infection, particularly coronavirus.
C1 [Enkhtur, Altansuvd; Yoon, Joon-Sup; Lee, Chang-Woo] Sungkyunkwan Univ, Dept Mol Cell Biol, Sch Med, 2066 Seobu Ro, Suwon 16419, South Korea.
   [Lee, Chang-Woo] Sungkyunkwan Univ, Samsung Adv Inst Hlth Sci & Technol SAIHST, Dept Hlth Sci & Technol, Seoul, South Korea.
C3 Sungkyunkwan University (SKKU); Samsung; Sungkyunkwan University (SKKU)
RP Lee, CW (corresponding author), Sungkyunkwan Univ, Dept Mol Cell Biol, Sch Med, 2066 Seobu Ro, Suwon 16419, South Korea.
EM cwlee1234@skku.edu
RI Lee, Chang-Woo/L-5093-2015
FU National Research Foundation (NRF) - Ministry of Education, Science, and
   Technology (MEST), Republic of Korea [2017R1A2B3006776,
   2018M3A9A8023731]
FX This study was supported by grants (2017R1A2B3006776, 2018M3A9A8023731)
   of National Research Foundation (NRF) funded by the Ministry of
   Education, Science, and Technology (MEST), Republic of Korea.
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NR 66
TC 1
Z9 1
U1 0
U2 1
PU SUNGKYUNKWAN UNIV SCH MEDICINE
PI SEOUL
PA 115 IRWON-RO, GANGNAM-GU, SEOUL, 06355, SOUTH KOREA
SN 2508-7940
EI 2508-7959
J9 PRECIS FUTURE MED
JI Precis. Future Med.
PD SEP
PY 2020
VL 4
IS 3
BP 83
EP 90
DI 10.23838/pfm.2020.00121
PG 8
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA PN1GO
UT WOS:000604234400002
OA gold
DA 2025-06-11
ER

PT J
AU D'Amelio, P
AF D'Amelio, Patrizia
TI Vitamin D Deficiency and Risk of Metabolic Syndrome in Aging Men
SO WORLD JOURNAL OF MENS HEALTH
LA English
DT Review
DE Aging; Gender identity; Metabolic syndrome; Vitamin D
ID LEUKOCYTE TELOMERE LENGTH; PARATHYROID-HORMONE LEVELS; SERUM
   25-HYDROXYVITAMIN D; OXIDATIVE STRESS; BLOOD-PRESSURE; NATIONAL-HEALTH;
   MITOCHONDRIAL DYSFUNCTION; CARDIOVASCULAR-DISEASE; PHYSICAL-ACTIVITY;
   LEISURE-TIME
AB The elderly population is rapidly increasing; hence, the disability due to age-related diseases has become an important socioeconomic burden. Amongst age-related diseases cardiovascular ones (CVD) have a huge impact on morbidity and mortality and are associated with metabolic syndrome (MetS). Several studies investigated the role of hypovitaminosis D in the pathogenesis of MetS and of CVD, this review unravels the relationship between aging/senescence, vitamin D, gender, and pathogenesis of MetS.
C1 [D'Amelio, Patrizia] Univ Lausanne, Dept Internal Med, Serv Geriatr Med & Geriatr Rehabil, Hosp Ctr, Lausanne, Switzerland.
C3 University of Lausanne
RP D'Amelio, P (corresponding author), Univ Lausanne, Hosp Ctr, Serv Geriatr Med & Geriatr Rehabil, Mt Paisible 16, CH-1011 Lausanne, Switzerland.
EM patrizia.damelio@chuv.ch
RI D'AMELIO, PATRIZIA/K-3042-2016
OI D'AMELIO, PATRIZIA/0000-0002-4467-8337
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NR 100
TC 6
Z9 6
U1 0
U2 6
PU KOREAN SOC SEXUAL MEDICINE & ANDROLOGY
PI BUSAN
PA PUSAN NATL UNIV MEDICAL SCH, DEPT UROLOGY, 179 GUDEOK-RO, SEO-GU, BUSAN,
   SOUTH KOREA
SN 2287-4208
EI 2287-4690
J9 WORLD J MENS HEALTH
JI World J. Mens Health
PD APR
PY 2021
VL 39
IS 2
BP 291
EP 301
DI 10.5534/wjmh.200189
PG 11
WC Andrology; Health Care Sciences & Services; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Health Care Sciences & Services; Urology &
   Nephrology
GA RB3AV
UT WOS:000631987400008
PM 33663024
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Lehto, SM
   Niskanen, L
   Miettola, J
   Tolmunen, T
   Viinamäki, H
   Mäntyselkä, P
AF Lehto, Soili M.
   Niskanen, Leo
   Miettola, Juhani
   Tolmunen, Tommi
   Viinamaki, Heimo
   Mantyselka, Pekka
TI Serum anti-inflammatory markers in general population subjects with
   elevated depressive symptoms
SO NEUROSCIENCE LETTERS
LA English
DT Article
DE Anti-inflammatory; Depression; General population; Interleukin-1
   receptor antagonist
ID INTERLEUKIN-1 RECEPTOR ANTAGONIST; MAJOR DEPRESSION; METABOLIC SYNDROME;
   ABNORMALITIES; INVENTORY; CYTOKINES
AB Anti-inflammatory substances have previously been suggested to show compensatory elevations in depressed individuals with pronounced inflammatory changes. In order to further clarify these observations, we examined depression-related alterations in the serum levels of anti-inflammatory markers interleukin (IL)-1 receptor antagonist (RA) and IL-10 and the pro-inflammatory marker IL-6 in 416 general population participants. Depression was evaluated with the Beck Depression Inventory (BM). Participants with elevated depressive symptoms (BDI > 14, n = 44) had increased levels of IL-1 RA and IL-6. No changes were observed in their IL-10 levels. In multivariate modeling with adjustments for age, gender, obesity, regular smoking, alcohol use, metabolic syndrome, physical exercise, sleep disturbance, and the use of non-steroidal anti-inflammatory drugs, a high level of IL-1 RA was associated with an increased likelihood of belonging to the group with elevated depressive symptoms (OR for each 1 SD increase in the serum level of IL-1 RA: 2.17, 95% CI 1.35-3.48, p = 0.001). The significance of IL-6 alterations did not persist in the same model. The pronounced secretion of anti-inflammatory marker IL-1 RA may reflect the presence of compensatory mechanisms during a depression-related inflammatory state. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
C1 [Lehto, Soili M.; Tolmunen, Tommi; Viinamaki, Heimo] Kuopio Univ Hosp, Dept Psychiat, SF-70210 Kuopio, Finland.
   [Lehto, Soili M.; Niskanen, Leo; Viinamaki, Heimo] Univ Eastern Finland, Inst Clin Med, Kuopio 70210, Finland.
   [Miettola, Juhani; Mantyselka, Pekka] Kuopio Univ Hosp, Unit Family Practice, Kuopio, Finland.
   [Mantyselka, Pekka] Univ Eastern Finland, Sch Med, Unit Primary Hlth Care, Kuopio 70210, Finland.
C3 University of Eastern Finland; University of Eastern Finland Hospital;
   Kuopio University Hospital; University of Eastern Finland; Kuopio
   University Hospital; University of Eastern Finland; University of
   Eastern Finland Hospital; University of Eastern Finland
RP Lehto, SM (corresponding author), Kuopio Univ Hosp, Dept Psychiat, POB 1777, FIN-70211 Kuopio, Finland.
EM Soili.Lehto@kuh.fi
OI Lehto, Soili/0000-0003-4324-6679
FU Lapinlahti Municipality; Prevention and Care of Diabetes in Finland
   through the Northern Savo Hospital District [DEHKO/D2D]
FX We express our gratitude to the Lapinlahti residents who took part in
   the study. We would also like to thank Professor Esko Kumpusalo, a
   central figure in initiating this study, the staff members of the
   Lapinlahti Primary Health Care Centre, and Kuopio University Hospital
   Medical Laboratory (especially Kari Punnonen, M.D., Ph.D.) for their
   contribution to the study. This study would not have been possible
   without the financial support of the Lapinlahti Municipality and the
   Development Programme for the Prevention and Care of Diabetes in Finland
   (DEHKO/D2D) through the Northern Savo Hospital District.
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NR 37
TC 24
Z9 27
U1 0
U2 8
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0304-3940
EI 1872-7972
J9 NEUROSCI LETT
JI Neurosci. Lett.
PD NOV 5
PY 2010
VL 484
IS 3
BP 201
EP 205
DI 10.1016/j.neulet.2010.08.054
PG 5
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 664XX
UT WOS:000282998400009
PM 20800651
DA 2025-06-11
ER

PT J
AU Zhang, Y
   Mei, SL
   Yang, R
   Chen, L
   Gao, H
   Li, L
AF Zhang, Ying
   Mei, Songli
   Yang, Rui
   Chen, Ling
   Gao, Hang
   Li, Li
TI Effects of lifestyle intervention using patient-centered cognitive
   behavioral therapy among patients with cardiometabolic syndrome: a
   randomized, controlled trial
SO BMC CARDIOVASCULAR DISORDERS
LA English
DT Article
DE China; Patient-centered; Cognitive behavioral therapy; Cardio-metabolic
   syndrome; Randomised controlled trial
ID METABOLIC SYNDROME; WEIGHT-LOSS; CARDIOVASCULAR-DISEASE; POSITION
   STATEMENT; UNITED-STATES; RISK-FACTORS; HEALTH; MANAGEMENT; DIET; CARE
AB Background: Cardio-metabolic syndrome (CMS) is a highly prevalent condition. There is an urgent need to identify effective and integrated multi-disciplinary approaches that can reduce risk factors for CMS.
   Methods: Sixty-two patients with a history of CMS were randomized 1: 1 into two groups: a standard information -only group (control), or a self-regulated lifestyle waist circumference (patient-centered cognitive behavioral therapy) intervention group. A pretest and posttest, controlled, experimental design was used. Outcomes were measured at the baseline (week 0) and at the end of intervention (week 12). Comparisons were drawn between groups and over time.
   Results: The mean (standard deviation) age of the subjects was 48.6 (5.8) years ranging from 32 to 63, and 56.9% of the participants were female. Both groups showed no significant differences in Demographic variables and the metabolic syndrome indicators at baseline. While the control group only showed modest improvement after 12 weeks, compared to baseline, the intervention group demonstrated significant improvement from baseline. This study controlled for patients' demographics and baseline characteristics when assessing the effects of intervention. After adjusting for age, education and baseline level, the experimental group and the control group were statistically significant different in the following post-treatment outcomes: WC (F = 35.96, P < 0.001), TG (F = 18.93, P < 0.001), RSBP (F = 33.89, P < 0.001) and SF-36(F = 157.93, P < 0.001). The results showed patients' age and education were not strong predictors of patients' outcome (including WC, TG, RSBP and SF-36).
   Conclusions: Lifestyle intervention on patient-centered cognitive behavioral therapy can improve the physical and mental health conditions among individuals reporting a history of cardio-metabolic syndrome, and possibly provided preliminary benefits for the treatment of CMS.
C1 [Zhang, Ying; Mei, Songli] Jilin Univ, Sch Publ Hlth, Dept Children & Adolescent Hlth Care, 1163 Xinmin St, Changchun 130021, Peoples R China.
   [Zhang, Ying] Jinzhou Med Univ, Affiliated Hosp 1, Dept Educ, Jinzhou, Peoples R China.
   [Yang, Rui; Chen, Ling; Gao, Hang] Jinzhou Med Univ, Affiliated Hosp 1, Dept Internal Med, Jinzhou, Peoples R China.
   [Li, Li] Jinzhou Med Univ, Fac Humanity Management, Jinzhou, Peoples R China.
C3 Jilin University; Jinzhou Medical University; Jinzhou Medical
   University; Jinzhou Medical University
RP Mei, SL (corresponding author), Jilin Univ, Sch Publ Hlth, Dept Children & Adolescent Hlth Care, 1163 Xinmin St, Changchun 130021, Peoples R China.
EM Meisongli111@sina.com
RI Mei, Songli/AAO-9831-2021
FU science and technology international cooperation project of Jilin
   Province in China [20160414035GH]; Liaoning University Students'
   Innovation and Entrepreneurship project [201510160000031]
FX The study was funded by the science and technology international
   cooperation project of Jilin Province (20160414035GH) in China and
   Liaoning University Students' Innovation and Entrepreneurship project
   (201510160000031).
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NR 51
TC 18
Z9 19
U1 0
U2 19
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-2261
J9 BMC CARDIOVASC DISOR
JI BMC Cardiovasc. Disord.
PD NOV 18
PY 2016
VL 16
AR 227
DI 10.1186/s12872-016-0398-9
PG 9
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Cardiovascular System & Cardiology
GA EC3QL
UT WOS:000388040600001
PM 27863480
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Rayssiguier, Y
   Libako, P
   Nowacki, W
   Rock, E
AF Rayssiguier, Yves
   Libako, Patrycja
   Nowacki, Wojciech
   Rock, Edmond
TI Magnesium deficiency and metabolic syndrome: stress and inflammation may
   reflect calcium activation
SO MAGNESIUM RESEARCH
LA English
DT Review
DE magnesium; calcium; metabolic syndrome; inflammation
ID DIETARY MAGNESIUM; INSULIN-RESISTANCE; ENDOTHELIAL DYSFUNCTION;
   CARDIOVASCULAR-DISEASE; DIABETES-MELLITUS; OXIDATIVE STRESS;
   BLOOD-PRESSURE; WOMEN; RATS; CELLS
AB Magnesium (Mg) intake is inadequate in the western diet and metabolic syndrome is highly prevalent in populations around the world. Epidemiological studies suggest that high Mg intake may reduce the risk but the possibility of confounding factors exists, given the strong association between Mg and other beneficial nutriments (vegetables, fibers, cereals). The concept that metabolic syndrome is an inflammatory condition may explain the role of Mg.
   Mg deficiency results in a stress effect and increased susceptibility to physiological damage produced by stress. Stress activates the hypothalamic-pituitary-adrenal axis (HPA) axis and the sympathetic nervous system. The activation of the renin-angiotensin-aldosterone system is a factor in the development of insulin resistance by increasing oxidative stress. In both humans and rats, aldosteronism results in an immunostimulatory state and leads to an inflammatory phenotype. Stress response induces the release of large quantities of excitatory amino acids and activates the nuclear factor NF kappa B, promoting translation of molecules involved in cell regulation, metabolism and apoptosis. The rise in neuropeptides is also well documented. Stress-induced HPA activation has been identified to play an important role in the preferential body fat accumulation but evidence that Mg is involved in body weight regulation is lacking. One of the earliest events in the acute response to stress is endothelial dysfunction. Endothelial cells actively contribute to inflammation by elaborating cytokines, synthesizing chemical mediators and expressing adhesion molecules. Experimental Mg deficiency in rats induces a clinical inflammatory syndrome characterized by leukocyte and macrophage activation, synthesis of inflammatory cytokines and acute phase proteins, extensive production of free radicals. An increase in extracellular Mg concentration decreases inflammatory effects, while reduction in extracellular Mg results in cell activation. The effect of Mg deficiency in the development of insulin resistance in the rat model is well documented. Inflammation occurring during experimental Mg deficiency is the mechanism that induces hypertriglyceridemia and pro-atherogenic changes in lipoprotein metabolism. The presence of endothelial dysfunction and dyslipidemia triggers platelet aggregability, thus increasing the risk of thrombotic events. Oxidative stress contributes to the elevation of blood pressure. The inflammatory syndrome induces activation of several factors, which are dependent on cytosolic Ca activation. Recent findings support the hypothesis that the Mg effect on intracellular Ca(2+) homeostasis may be a common link between stress, inflammation and a possible relationship to metabolic syndrome.
C1 [Rayssiguier, Yves; Rock, Edmond] Univ Auvergne, Clermont Univ, CRNH Auvergne, INRA,UNH,UMR 1019, Clermont Ferrand, France.
   [Libako, Patrycja; Nowacki, Wojciech] Wroclaw Univ Environm & Life Sci, Fac Vet Med, Wroclaw, Poland.
C3 Universite Clermont Auvergne (UCA); INRAE; Wroclaw University of
   Environmental & Life Sciences
RP Rayssiguier, Y (corresponding author), INRA, Unite Nutr Humaine, F-63122 St Genes Champanelle, France.
EM yves.rayssiguier@orange.fr
OI Nowacki, Wojciech/0000-0002-8304-0686
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NR 51
TC 70
Z9 80
U1 0
U2 13
PU JOHN LIBBEY EUROTEXT LTD
PI MONTROUGE
PA 127 AVE DE LA REPUBLIQUE, 92120 MONTROUGE, FRANCE
SN 0953-1424
J9 MAGNESIUM RES
JI Magnes. Res.
PD JUN
PY 2010
VL 23
IS 2
BP 73
EP 80
PG 8
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 618LN
UT WOS:000279356100002
PM 20513641
DA 2025-06-11
ER

PT J
AU Velasquez, C
   Vasquez, JS
   Balcazar, N
AF Velasquez, Claudia
   Sebastian Vasquez, Juan
   Balcazar, Norman
TI In Vitro Effect of Fatty Acids Identified in the Plasma of Obese
   Adolescents on the Function of Pancreatic β-Cells
SO DIABETES & METABOLISM JOURNAL
LA English
DT Article
DE Fatty acids; nonesterified; Insulin-secreting cells; Lipotoxicity;
   Metabolic syndrome; Obesity
ID ENDOPLASMIC-RETICULUM STRESS; INDUCED APOPTOSIS; ABDOMINAL OBESITY;
   MITOCHONDRIAL; INFLAMMATION; PALMITATE; PATHWAY; DYSFUNCTION;
   INHIBITION; ACTIVATION
AB Background: The increase in circulating free fatty acid (FFA) levels is a major factor that induces malfunction in pancreatic beta-cells. We evaluated the effect of FFAs reconstituted according to the profile of circulating fatty acids found in obese adolescents on the viability and function of the murine insulinoma cell line (mouse insulinoma [MIN6]).
   Methods: From fatty acids obtained commercially, plasma-FFA profiles of three different youth populations were reconstituted: obese with metabolic syndrome; obese without metabolic syndrome; and normal weight without metabolic syndrome. MIN6 cells were treated for 24 or 48 hours with the three FFA profiles, and glucose-stimulated insulin secretion, cell viability, mitochondrial function and antioxidant activity were evaluated.
   Results: The high FFA content and high polyunsaturated omega 6/omega 3 ratio, present in plasma of obese adolescents with metabolic syndrome had a toxic effect on MIN6 cell viability and function, increasing oxidative stress and decreasing glucose-dependent insulin secretion.
   Conclusion: These results could help to guide nutritional management of obese young individuals, encouraging the increase of omega-3-rich food consumption in order to reduce the likelihood of deterioration of beta-cells and the possible development of type 2 diabetes mellitus.
C1 [Velasquez, Claudia] Univ Antioquia, Sch Dietet & Human Nutr, Res Grp Food & Human Nutr, Medellin, Colombia.
   [Sebastian Vasquez, Juan; Balcazar, Norman] Univ Antioquia, Mol Genet Grp, Calle 62 52-59, Medellin 1226, Colombia.
   [Balcazar, Norman] Univ Antioquia, Sch Med, Dept Physiol & Biochem, Calle 62 52-59, Medellin 1226, Colombia.
C3 Universidad de Antioquia; Universidad de Antioquia; Universidad de
   Antioquia
RP Balcazar, N (corresponding author), Univ Antioquia, Mol Genet Grp, Calle 62 52-59, Medellin 1226, Colombia.; Balcazar, N (corresponding author), Univ Antioquia, Sch Med, Dept Physiol & Biochem, Calle 62 52-59, Medellin 1226, Colombia.
EM norman.balcazar@udea.edu.co
FU COLCIENCIAS (Colombia) [1115-569-33200]
FX We thank Anne-Lise Haenni for her critical review. This study was
   supported by COLCIENCIAS (Colombia) grant No. 1115-569-33200.
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NR 39
TC 8
Z9 8
U1 0
U2 7
PU KOREAN DIABETES ASSOC
PI SEOUL
PA 101-2104, LOTTE CASTLE PRES, 109 MAPO-DAERO, MAPO-GU, SEOUL, 04146,
   SOUTH KOREA
SN 2233-6079
EI 2233-6087
J9 DIABETES METAB J
JI Diabetes Metab. J.
PD AUG
PY 2017
VL 41
IS 4
BP 303
EP 315
DI 10.4093/dmj.2017.41.4.303
PG 13
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA FH5OJ
UT WOS:000411216400008
PM 28868828
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Machado, M
   Cortez-Pinto, H
AF Machado, Mariana
   Cortez-Pinto, Helena
TI Non-alcoholic steatohepatitis and metabolic syndrome
SO CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE
LA English
DT Article
DE adipokines; insulin resistance; metabolic syndrome; non-alcoholic fatty
   liver disease; non-alcoholic steatohepatitis
ID FATTY LIVER-DISEASE; INSULIN-RESISTANCE; HEPATIC STEATOSIS; OXIDATIVE
   STRESS; WEIGHT-LOSS; FIBROSIS; ADIPONECTIN; ARTICLE; NASH; ACCUMULATION
AB Purpose of review
   Non-alcoholic steatohepatitis is part of a disease spectrum, non-alcoholic fatty liver disease, ranging from simple steatosis to cirrhosis, which is the most frequent cause of abnormal liver tests. There is clinical and epidemiological evidence that non-alcoholic fatty liver disease is the hepatic manifestation of the metabolic syndrome, having in common insulin resistance.
   Recent findings
   The interest in the metabolic syndrome concept has been questioned. Insulin resistance oxidative stress, mitochondrial dysfunction immune deregulation and adipokines seem to be crucial in the pathogenesis of non-alcoholic fatty liver disease. the main treatment continues to rely on lifestyle changes, including weight loss strategies. Bariatric surgery in morbidly obese patients and insulin-sensitizing agents seem to be beneficial.
   Summary
   There is strong evidence of the association of non-alcoholic steatohepatitis wit the features of the metabolic syndrome, with its increased cardiovascular risk. Population interventions in order to change lifestyles and diet patterns that constitute risk factors for both situations are urgently needed. There is, how er, evidence that in the presence of other risk factors, insulin resistance may be less important. These secondary forms of non-alcoholic steatohepatitis must be recognized, as they are potentially treatable by withdrawing the steatogenic factor.
C1 Hosp Santa Maria, Dept Gastroenterol, Inst Mol Med, Unidade Nutr & Metab, P-1649035 Lisbon, Portugal.
C3 Universidade de Lisboa; Hospital Santa Maria
RP Cortez-Pinto, H (corresponding author), Hosp Santa Maria, Dept Gastroenterol, Inst Mol Med, Unidade Nutr & Metab, Av Prof Egas Moniz, P-1649035 Lisbon, Portugal.
EM hlcortezpinto@netcabo.pt
RI Cortez-Pinto, Helena/AAN-2712-2020
OI Cortez-Pinto, Helena/0000-0002-8537-8744
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NR 66
TC 99
Z9 112
U1 0
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1363-1950
EI 1473-6519
J9 CURR OPIN CLIN NUTR
JI Curr. Opin. Clin. Nutr. Metab. Care
PD SEP
PY 2006
VL 9
IS 5
BP 637
EP 642
DI 10.1097/01.mco.0000241677.40170.17
PG 6
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 083VS
UT WOS:000240486900017
PM 16912563
DA 2025-06-11
ER

PT J
AU Pompeia, S
   Panjeh, S
   Louzada, FM
   D'Almeida, V
   Hipolide, DC
   Cogo-Moreira, H
AF Pompeia, Sabine
   Panjeh, Sareh
   Louzada, Fernando Mazzili
   D'Almeida, Vania
   Hipolide, Debora Cristina
   Cogo-Moreira, Hugo
TI Social jetlag is associated with adverse cardiometabolic latent traits
   in early adolescence: an observational study
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Article
DE adolescence; social jetlag; sleep; metabolic syndrome; cardiometabolism
ID SHORT-SLEEP DURATION; BODY-MASS INDEX; METABOLIC SYNDROME; OBESITY;
   CHILDREN; RISK; ADIPOSITY; NUTRITION; PUBERTY; QUALITY
AB IntroductionAdolescence is marked by physiological and social changes, such as puberty, increased responsibilities and earlier school start times. This often leads to insufficient sleep on school nights and the need to compensate for lost sleep on weekends, causing a misalignment between biological and social times, which has been termed social jetlag (SJL). SJL triggers stress responses and is associated with several negative health outcomes, including higher cardiometabolic risk in adults. In adolescence, however, SJL has only been consistently related to increases in adiposity but its association with other cardiometabolic indicators are unclear. MethodIn a sample of 278 healthy early adolescents (9-15 years of age; 168 girls) we investigated: 1) whether self-reported SJL is associated (using path analyses) with a cardiometabolic status latent factor obtained by testing the best fitting model via confirmatory factor analyses from an initial set of eight indicators [body mass index (BMI), waist/height ratio, triglyceride concentration, diastolic and systolic blood pressure, glycated hemoglobin, total cholesterol/high-density lipoprotein ratio (chol/HDL), and % body fat]; and 2) whether age and/or pubertal status influence the association between SJL and cardiometabolic status. ResultWe found that, for girls, higher SJL was associated with more adverse cardiometabolic latent scores (the shared variance of BMI, waist/height ratio, chol/HDL and systolic blood pressure, which had acceptable model fit indices). However, the role of age and pubertal status in this association was unclear for both sexes. DiscussionSJL was associated with adverse cardiometabolic latent traits beyond increases in adiposity in this observational study in early female adolescents. Because disruptions of circadian rhythms are believed to lead to dysregulated energy homeostasis and not vice-versa, our findings highlight the need for sleep interventions in adolescence to help reduce the global burden of cardiometabolic ill health, especially in girls.
C1 [Pompeia, Sabine; D'Almeida, Vania; Hipolide, Debora Cristina] Univ Fed Sao Paulo, Dept Psicobiol, Sao Paulo, Brazil.
   [Panjeh, Sareh; Cogo-Moreira, Hugo] Univ Fed Sao Paulo, Dept Psiquiatria, Sao Paulo, Brazil.
   [Louzada, Fernando Mazzili] Univ Fed Parana, Dept Fisiol, Curitiba, Brazil.
   [Cogo-Moreira, Hugo] Ostfold Univ Coll, Dept Educ ICT & Learning, Halden, Norway.
C3 Universidade Federal de Sao Paulo (UNIFESP); Universidade Federal de Sao
   Paulo (UNIFESP); Universidade Federal do Parana; Ostfold University
   College
RP Cogo-Moreira, H (corresponding author), Univ Fed Sao Paulo, Dept Psiquiatria, Sao Paulo, Brazil.; Cogo-Moreira, H (corresponding author), Ostfold Univ Coll, Dept Educ ICT & Learning, Halden, Norway.
EM hugo.c.moreira@hiof.no
RI Pompeia, Sabine/F-9906-2012; Cogo-Moreira, Hugo/E-4602-2011; Louzada,
   Fernando/N-9809-2016; Hipolide, Debora/B-5810-2013; D'Almeida,
   Vania/AAB-7115-2020; Panjeh, Sareh/AAE-4384-2021
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NR 93
TC 8
Z9 8
U1 1
U2 5
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD JUL 4
PY 2023
VL 14
AR 1085302
DI 10.3389/fendo.2023.1085302
PG 15
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA M0NX8
UT WOS:001027184700001
PM 37469985
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Alam, MA
   Subhan, N
   Rahman, MM
   Uddin, SJ
   Reza, HM
   Sarker, SD
AF Alam, M. Ashraful
   Subhan, Nusrat
   Rahman, M. Mahbubur
   Uddin, Shaikh J.
   Reza, Hasan M.
   Sarker, Satyajit D.
TI Effect of Citrus Flavonoids, Naringin and Naringenin, on Metabolic
   Syndrome and Their Mechanisms of Action
SO ADVANCES IN NUTRITION
LA English
DT Review
ID NECROSIS-FACTOR-ALPHA; INSULIN-RECEPTOR SUBSTRATE-1; HIGH-FAT;
   HIGH-CARBOHYDRATE; ORANGE JUICE; GRAPEFRUIT JUICE; OXIDATIVE STRESS;
   APOLIPOPROTEIN-B; INDUCED TOXICITY; BETA-OXIDATION
AB Flavonoids are important natural compounds with diverse biologic activities. Citrus flavonoids constitute an important series of flavonoids. Naringin and its aglycone naringenin belong to this series of flavonoids and were found to display strong anti-inflammatory and antioxidant activities. Several lines of investigation suggest that naringin supplementation is beneficial for the treatment of obesity, diabetes, hypertension, and metabolic syndrome. A number of molecular mechanisms underlying its beneficial activities have been elucidated. However, their effect on obesity and metabolic disorder remains to be fully established. Moreover, the therapeutic uses of these flavonoids are significantly limited by the lack of adequate clinical evidence. This review aims to explore the biologic activities of these compounds, particularly on lipid metabolism in obesity, oxidative stress, and inflammation in context of metabolic syndrome.
C1 [Alam, M. Ashraful] Univ Queensland, Sch Biomed Sci, Brisbane, Qld, Australia.
   [Alam, M. Ashraful; Rahman, M. Mahbubur; Reza, Hasan M.] North South Univ, Dept Pharmaceut Sci, Dhaka, Bangladesh.
   [Subhan, Nusrat] Charles Sturt Univ, Sch Biomed Sci, Wagga Wagga, NSW, Australia.
   [Uddin, Shaikh J.] Khulna Univ, Pharm Discipline, Khulna, Bangladesh.
   [Sarker, Satyajit D.] Liverpool John Moores Univ, Fac Sci, Sch Pharm & Biomol Sci, Liverpool L3 5UX, Merseyside, England.
C3 University of Queensland; North South University (NSU); Charles Sturt
   University; Khulna University; Liverpool John Moores University
RP Alam, MA (corresponding author), Univ Queensland, Sch Biomed Sci, Brisbane, Qld, Australia.
EM sonaliagun@yahoo.com
RI Alam, Ashraful/G-1964-2014; Uddin, Shaih/AAD-7145-2020; Sarker,
   Satyajit/ABC-6278-2021; Reza, Hasan Mahmud/AFL-0151-2022
OI Sarker, Satyajit/0000-0003-4038-0514; Rahman, Md.
   Mahbubur/0000-0003-3027-0354; Uddin, Shaikh Jamal/0000-0003-3163-2118;
   Alam, Md Ashraful/0000-0001-7596-5868; Reza, Hasan
   Mahmud/0000-0003-3287-942X
FU School of Biomedical Sciences, Charles Sturt University, Australia
FX N.S. is supported by faculty PhD scholarship from the School of
   Biomedical Sciences, Charles Sturt University, Australia.
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NR 140
TC 535
Z9 576
U1 23
U2 270
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 2161-8313
EI 2156-5376
J9 ADV NUTR
JI Adv. Nutr.
PD JUL
PY 2014
VL 5
IS 4
BP 404
EP 417
DI 10.3945/an.113.005603
PG 14
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA AM1XT
UT WOS:000339643300004
PM 25022990
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Zhang, JW
   Xu, CF
   Zhao, Y
   Chen, Y
AF Zhang, Juanwen
   Xu, Chengfu
   Zhao, Ying
   Chen, Yu
TI The Significance of Serum Xanthine Oxidoreductase in Patients with
   Nonalcoholic Fatty Liver Disease
SO CLINICAL LABORATORY
LA English
DT Article
DE xanthine oxidoreductase; uric acid; nonalcoholic fatty liver disease;
   metabolic syndrome
ID URIC-ACID; DEHYDROGENASE GENE; METABOLIC SYNDROME; OXIDATIVE STRESS;
   OXIDASE; ALLOPURINOL; DIAGNOSIS; ATHEROSCLEROSIS; IDENTIFICATION;
   ASSOCIATION
AB Background: Serum uric acid levels are significantly associated with nonalcoholic fatty liver disease (NAFLD). Xanthine oxidoreductase (XOR) is the key enzyme that catalyzes the formation of uric acid. The aim of this study was to investigate the association between serum XOR activity and NAFLD.
   Methods: In this cross-sectional study, serum XOR activity was measured by enzyme-linked immunosorbent assay in 129 patients with NAFLD and 71 controls.
   Results: Serum XOR activity was markedly higher in patients with NAFLD than in the controls (p < 0.001). Serum XOR activity positively correlated with markers of liver injury and indices of oxidative stress. Moreover, patients with high XOR activity had a higher prevalence of metabolic syndrome.
   Conclusions: These data show that serum XOR activity is significantly associated with NAFLD.
C1 [Zhang, Juanwen; Zhao, Ying; Chen, Yu] Zhejiang Univ, Coll Med, Affiliated Hosp 1, Dept Lab Med, Hangzhou 310003, Zhejiang, Peoples R China.
   [Xu, Chengfu] Zhejiang Univ, Coll Med, Affiliated Hosp 1, Dept Gastroenterol, Hangzhou 310003, Zhejiang, Peoples R China.
C3 Zhejiang University; Zhejiang University
RP Chen, Y (corresponding author), Zhejiang Univ, Coll Med, Affiliated Hosp 1, Dept Lab Med, 79 Qingchun Rd, Hangzhou 310003, Zhejiang, Peoples R China.
EM tym2011@yeah.net
RI zhao, yingying/HHC-8693-2022; Xu, Chengfu/HTL-9950-2023
OI Xu, Chengfu/0000-0002-6172-1253
FU National Natural Science Foundation of China [81100278]; Science
   Foundation of Health Bureau of Zhejiang Province [2012RCA026]
FX The authors thank the technicians at the Associated This study was
   supported by the National Natural Science Foundation of China (No.
   81100278) and the Science Foundation of Health Bureau of Zhejiang
   Province (No. 2012RCA026). The funders had no role in study design, data
   collection and analysis, decision to publish, or preparation of the
   manuscript.
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NR 36
TC 14
Z9 15
U1 1
U2 14
PU CLIN LAB PUBL
PI HEIDELBERG
PA IM BREITSPIEL 15, HEIDELBERG, D-69126, GERMANY
SN 1433-6510
J9 CLIN LAB
JI Clin. Lab.
PY 2014
VL 60
IS 8
BP 1301
EP 1307
DI 10.7754/Clin.Lab.2013.130516
PG 7
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA AQ5OF
UT WOS:000342857800006
PM 25185415
DA 2025-06-11
ER

PT J
AU Farrokhfall, K
   Khoshbaten, A
   Zahediasl, S
   Mehrani, H
   Karbalaei, N
AF Farrokhfall, Khadije
   Khoshbaten, Ali
   Zahediasl, Saleh
   Mehrani, Hossein
   Karbalaei, Narges
TI Improved islet function is associated with anti-inflammatory,
   antioxidant and hypoglycemic potential of cinnamaldehyde on metabolic
   syndrome induced by high tail fat in rats
SO JOURNAL OF FUNCTIONAL FOODS
LA English
DT Article
DE High fat diet; Cinnamaldehyde; Metabolic syndrome; Oxidative stress; Rat
ID STIMULATED INSULIN-SECRETION; LIPID PROFILE; DIET; GLUCOSE; CINNAMON;
   RESISTANCE; SUPPLEMENTATION; PARAMETERS; CYTOKINES; PRESSURE
AB Cinnamon is used in traditional medicine and foods. In this study the protective effects of cinnamaldehyde, one of the most abundant compound of cinnamon against metabolic syndrome induced by high fat diet, were investigated. To induce metabolic syndrome, male Wistar rats were given high fat diet for 16 weeks. Cinnamaldehyde was administrated orally (143.8 mu mol/kg body weight) concomitant with high fat feed. Changes in islet morphology, lipid profile, TNF-alpha, TBARS, insulin resistance were analyzed. Metabolic syndrome was induced by high fat diet. Cinnamaldehyde reversed this process and significantly reduced insulin secretion and content in isolated islets of high fat diet. Beta cell enlargement, TNF-alpha and TBARS significantly increased with high fat diet, cinnamaldehyde restored both to the control level. Cinnamaldehyde prevented all symptoms of metabolic syndrome by improving oxidative and inflammatory conditions in pancreatic islets with no effect on insulin secretion but by enhancing insulin reserve and preventing beta cell damage. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Farrokhfall, Khadije] Baqiyatallah Univ Med Sci, Neurosci Res Ctr, Tehran, Iran.
   [Farrokhfall, Khadije; Khoshbaten, Ali] Baqiyatallah As Univ Med Sci, Fac Med, Dept Physiol & Biophys, Tehran, Iran.
   [Zahediasl, Saleh] Shahid Beheshti Univ Med Sci, Res Inst Endocrine Sci, Endocrine Physiol Res Ctr, Tehran, Iran.
   [Mehrani, Hossein] Baqiyatallah Univ Med Sci, Chem Injuries Res Ctr, Lab Prote, Tehran, Iran.
   [Karbalaei, Narges] Shiraz Univ Med Sci, Fac Med, Dept Physiol, Shiraz, Iran.
C3 Baqiyatallah University of Medical Sciences (BMSU); Shahid Beheshti
   University Medical Sciences; Baqiyatallah University of Medical Sciences
   (BMSU); Shiraz University of Medical Science
RP Mehrani, H (corresponding author), Baqiyatallah Univ Med Sci, Chem Injuries Res Ctr, Lab Prote, Tehran, Iran.
EM hosseinmehrani@ymail.com
RI farrokhfall, khadijeh/T-8084-2017; Karbalaei, Narges/T-7353-2017
OI Karbalaei, Narges/0000-0003-4619-2872; Farrokhfal,
   Khadige/0000-0003-0330-4061
FU Neurosciences Research Center, Baqiyatallah (a.s.) University of Medical
   Sciences
FX This manuscript is part of a PhD thesis for Khadije Farrokhfall, funded
   by the Neurosciences Research Center, Baqiyatallah (a.s.) University of
   Medical Sciences. The authors wish to thank Dr Masoud Sotoodeh,
   professor of pathology and laboratory medicine of school of Medicine,
   Tehran University of Medical Sciences, for skillful immunostaining
   facilitation of the study.
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NR 41
TC 31
Z9 34
U1 1
U2 28
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1756-4646
J9 J FUNCT FOODS
JI J. Funct. Food.
PD SEP
PY 2014
VL 10
BP 397
EP 406
DI 10.1016/j.jff.2014.07.014
PG 10
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA AP4GC
UT WOS:000342034200043
DA 2025-06-11
ER

PT J
AU Davì, G
   Santilli, F
   Patrono, C
AF Davi, Giovanni
   Santilli, Francesca
   Patrono, Carlo
TI Nutraceuticals in Diabetes and Metabolic Syndrome
SO CARDIOVASCULAR THERAPEUTICS
LA English
DT Review
DE Diabetes; Metabolic syndrome; Oxidative stress; Platelet activation;
   Vitamin
ID CORONARY-HEART-DISEASE; VITAMIN-E SUPPLEMENTATION; ALPHA-LIPOIC ACID;
   CARDIOVASCULAR-DISEASE; PLATELET ACTIVATION; LIPID-PEROXIDATION;
   OXIDATIVE STRESS; FLAVONOID INTAKE; ALCOHOL-CONSUMPTION;
   INSULIN-RESISTANCE
AB P>Metabolic syndrome represents a clustering of risk factors related to an elevated risk of cardiovascular disease and type 2 diabetes. Occurrence of both metabolic syndrome and diabetes and their vascular complications share several pathogenetic features including subclinical, low-grade inflammation, altered oxidative/antioxidant status, and persistent platelet activation. Despite the availability of multiple interventions to counteract these metabolic changes, including appropriate diet, regular exercise, weight control and drugs, epidemiological data are witnessing the growing trend of the problem, reflecting both the multifactorial nature of these diseases as well as the scarce compliance of patients to established strategies. Several nutraceuticals used in clinical practice have been shown to target the pathogenesis of diabetes mellitus, metabolic syndrome and their complications and to favorably modulate a number of biochemical and clinical endpoints. These compounds include antioxidant vitamins, such as vitamins C and E, flavonoids, vitamin D, conjugated linoleic acid, omega-3 fatty acids, minerals such as chromium and magnesium, alpha-lipoic acid, phytoestrogens, and dietary fibers. Several areas of concern exist regarding the use of dietary supplements and nutraceuticals in this setting, including product standardization, definition of optimal dosing regimen, potential side effects, drug interactions, and need for evidence-based indications.
C1 [Davi, Giovanni; Santilli, Francesca; Patrono, Carlo] Catholic Univ, Sch Med, Dept Pharmacol, I-00168 Rome, Italy.
   [Davi, Giovanni; Santilli, Francesca; Patrono, Carlo] Univ G dAnnunzio, Ctr Excellence Aging, Chieti, Italy.
C3 Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli; G
   d'Annunzio University of Chieti-Pescara
RP Patrono, C (corresponding author), Catholic Univ, Sch Med, Dept Pharmacol, Largo F Vito 1, I-00168 Rome, Italy.
EM carlo.patrono@rm.unicatt.it
RI Santilli, Francesca/ABC-6243-2021; Davi, Giovanni/K-7659-2016
OI Santilli, Francesca/0000-0002-4593-905X; Davi,
   Giovanni/0000-0002-3044-0870; Patrono, Carlo/0000-0002-6447-2424
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NR 60
TC 100
Z9 108
U1 0
U2 27
PU WILEY-HINDAWI
PI LONDON
PA ADAM HOUSE, 3RD FL, 1 FITZROY SQ, LONDON, WIT 5HE, ENGLAND
SN 1755-5914
EI 1755-5922
J9 CARDIOVASC THER
JI Cardiovasc. Ther.
PY 2010
VL 28
IS 4
BP 216
EP 226
DI 10.1111/j.1755-5922.2010.00179.x
PG 11
WC Cardiac & Cardiovascular Systems; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Pharmacology & Pharmacy
GA 620WL
UT WOS:000279532000010
PM 20633024
OA Bronze
DA 2025-06-11
ER

PT J
AU Ferrara, D
   Montecucco, F
   Dallegri, F
   Carbone, F
AF Ferrara, Daniele
   Montecucco, Fabrizio
   Dallegri, Franco
   Carbone, Federico
TI Impact of different ectopic fat depots on cardiovascular and metabolic
   diseases
SO JOURNAL OF CELLULAR PHYSIOLOGY
LA English
DT Review
DE epicardial fat; free fatty acids; hepatic fat; lipotoxicity; myocardial
   fat; pancreatic fat; renal sinus fat
ID EPICARDIAL ADIPOSE-TISSUE; MYOCARDIAL TRIGLYCERIDE CONTENT;
   ENDOPLASMIC-RETICULUM STRESS; PREVENTS RENAL LIPOTOXICITY;
   CORONARY-ARTERY-DISEASE; LIVER-DISEASE; OBESE-PATIENTS; LIFE-STYLE;
   INDEPENDENT PREDICTOR; PANCREATIC STEATOSIS
AB A growing body of evidence is pointing out the pathophysiological role of fat accumulation in different organs. Ectopic fat depots within heart, liver, skeletal muscle, kidney, and pancreas as well as around blood vessels might be more associated to cardiometabolic risk than classical variables, such as body mass index. Among different mechanisms, lipid metabolism appears to be particularly influenced by ectopic fat depots. Indeed, intracellular accumulation of nonesterified fatty acids, and triglycerides promotes endoplasmic reticulum stress, mitochondrial uncoupling, oxidative stress, and altered membrane composition/function, finally promoting inflammatory response and cell death. The dysfunctional adipose tissue was shown to induce both local and systemic effects, with relevant clinical consequences. Epicardial fat and myocardial steatosis have been associated with the development of atrial fibrillation and ventricular dysfunction. Similarly perivascular adipose tissue appears to trigger atherosclerosis and hypertension. Nonalcoholic fatty liver disease has been recognized both as the hepatic manifestation of metabolic syndrome and as a cardiovascular (CV) risk factor. Importantly, the renal sinus fat emerged as a potential player in kidney dysfunction. Finally, both skeletal muscle and pancreatic fat depots have been indicated as potential endocrine modulators of insulin resistance. Considering the global rise in the prevalence of obesity, the understanding of mechanisms underlying ectopic fat accumulation represents an urgent need, with potential clinical implications for CV risk stratification. Here, we attempt to update the current knowledge of the different ectopic fat depots, focusing on underlying mechanisms and potential clinical implications.
C1 [Ferrara, Daniele; Dallegri, Franco; Carbone, Federico] Univ Genoa, Clin Internal Med 1, Dept Internal Med, 6 Viale Benedetto XV, I-16132 Genoa, Italy.
   [Montecucco, Fabrizio] Univ Genoa, Clin Internal Med 1, Dept Internal Med, CEBR, Genoa, Italy.
   [Montecucco, Fabrizio; Dallegri, Franco; Carbone, Federico] IRCCS Osped Policlin San Martino Genoa, Italian Cardiovasc Network, Genoa, Italy.
C3 University of Genoa; University of Genoa; University of Genoa; IRCCS AOU
   San Martino IST
RP Carbone, F (corresponding author), Univ Genoa, Clin Internal Med 1, Dept Internal Med, 6 Viale Benedetto XV, I-16132 Genoa, Italy.
EM federico.carbone@unige.it
RI Ferrara, Daniele/AAH-7655-2020; Montecucco, Fabrizio/K-8543-2016;
   Carbone, Federico/G-3650-2013
OI Carbone, Federico/0000-0003-2957-4078; Ferrara,
   Daniele/0000-0002-9875-2010
FU Ministero della Salute; Fondazione CARIGE; Italian Ministry of Health to
   the Italian Cardiovascular Network
FX Ministero della Salute; Fondazione CARIGE; Italian Ministry of Health to
   the Italian Cardiovascular Network
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NR 139
TC 137
Z9 146
U1 0
U2 78
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0021-9541
EI 1097-4652
J9 J CELL PHYSIOL
JI J. Cell. Physiol.
PD DEC
PY 2019
VL 234
IS 12
BP 21630
EP 21641
DI 10.1002/jcp.28821
PG 12
WC Cell Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Physiology
GA IV6KF
UT WOS:000484376600017
PM 31106419
DA 2025-06-11
ER

PT J
AU Queiroz, DJM
   Silva, AS
   Dinis, AD
   de Carvalho, AT
   Araújo, EPD
   Neves, JPR
   de Lacerda, LM
   Toscano, LT
   Gonçalves, MDR
AF Marques Queiroz, Dayana Joyce
   Silva, Alexandre Sergio
   Dinis, Alcides da Silva
   de Carvalho, Alice Teles
   dos Santos Araujo, Eduarda Pontes
   Ramos Neves, Juliana Padilha
   de lacerda, Lavoisiana Mateus
   Toscano, Lydiane Tavares
   Rodrigues Goncalves, Maria da Conceicao
TI Vitamin D insufficiency/deficiency and its association with
   cardiometabolic risk factors in Brazilian adolescents
SO NUTRICION HOSPITALARIA
LA English
DT Article
DE Vitamin D; Adolescent; Metabolic diseases; Oxidative stress
ID D DEFICIENCY; 25-HYDROXYVITAMIN D; OXIDATIVE STRESS; INFLAMMATION;
   PREVALENCE; BIOMARKERS; SOCIETY; HEALTH; RATIO; WAIST
AB Objective: this study aimed to investigate the association between serum 25-hydroxyvitamin D (25 [OH] D) and cardiometabolic risk factors in Brazilian adolescents.
   Methods: a cross-sectional study with 220 school adolescents aged 15 to 19 years was performed in the city of Joao Pessoa-PB, Brazil. The variables studied were: 25 hydroxyvitamin D (25 OH), dietary intake of vitamin D, anthropometric data (body mass index (BMI), waist circumference (WC) and waist/height ratio (RCA) and biochemistry, total cholesterol (TC), Low Density Lipoprotein (LDL), High Density Lipoproteins (HDL), triglyceride (TG), C-reactive protein (CRP), alpha acid glycoprotein (AGPA), malondialdehyde (MDA) and total antioxidant capacity (CAT), blood pressure, parathyroid hormone (PTH) and serum calcium. Enough and insufficient/deficient adolescents were compared by qui-square test and analysis of multiple lineal regression was accomplished to identify the factors cardiometabolicos associated to the concentration serica of 25 (OH) D (p < 0,05).
   Results: a total of 57.3% had vitamin D insufficiency/deficiency, which was more prevalent in females (79.35%). The chi-square test revealed an evident relationship between the three indicators involved in overweight assessed in this study BMI (p=0.01), WC (p=0.04) and AGR (p=0.02). There was an association between the independent variable (vitamin D) and calcium and triglyceride levels.
   Conclusion: a high proportion of adolescents presenting insufficiency/vitamin D deficiency was ssociated with cardiometabolic risk factors.
C1 [Marques Queiroz, Dayana Joyce; dos Santos Araujo, Eduarda Pontes; Ramos Neves, Juliana Padilha; de lacerda, Lavoisiana Mateus; Toscano, Lydiane Tavares] Univ Fed Paraiba, Grad Program Nutr Sci, BR-58033455 Joao Pessoa, Paraiba, Brazil.
   [de Carvalho, Alice Teles; Rodrigues Goncalves, Maria da Conceicao] Univ Fed Paraiba, Dept Nutr, Postgrad Program Nutr Sci, Joao Pessoa, Paraiba, Brazil.
   [Silva, Alexandre Sergio] Univ Fed Paraiba, Dept Phys Educ, Grad Program Nutr Sci, Joao Pessoa, Paraiba, Brazil.
   [Dinis, Alcides da Silva] Univ Fed Pernambuco, Hlth Sci Ctr, Dept Nutr, Recife, PE, Brazil.
C3 Universidade Federal da Paraiba; Universidade Federal da Paraiba;
   Universidade Federal da Paraiba; Universidade Federal de Pernambuco
RP Queiroz, DJM (corresponding author), Univ Fed Paraiba, Grad Program Nutr Sci, BR-58033455 Joao Pessoa, Paraiba, Brazil.
EM dayannamestrado@gmail.com
RI dos Santos Araújo, Eduarda/A-3767-2019; Silva, Alexandre
   Sergio/N-8883-2014
OI Silva, Alexandre Sergio/0000-0003-3576-9023
CR [Anonymous], 2010, DIETARY REFERENCE IN
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NR 35
TC 9
Z9 9
U1 0
U2 6
PU ARAN EDICIONES, S L
PI MADRID
PA C/ CASTELLO, 128, 1O, MADRID, 28006, SPAIN
SN 0212-1611
EI 1699-5198
J9 NUTR HOSP
JI Nutr. Hosp.
PD JAN-FEB
PY 2019
VL 36
IS 1
BP 142
EP 148
DI 10.20960/nh.1884
PG 7
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA HM7ZX
UT WOS:000459699300023
PM 30836756
OA gold
DA 2025-06-11
ER

PT J
AU Silarova, B
   Giltay, EJ
   Dortland, AV
   Van Rossum, EFC
   Hoencamp, E
   Penninx, BWJH
   Spijker, AT
AF Silarova, Barbora
   Giltay, Erik J.
   Dortland, Arianne Van Reedt
   Van Rossum, Elisabeth F. C.
   Hoencamp, Erik
   Penninx, Brenda W. J. H.
   Spijker, Annet T.
TI Metabolic syndrome in patients with bipolar disorder: Comparison with
   major depressive disorder and non-psychiatric controls
SO JOURNAL OF PSYCHOSOMATIC RESEARCH
LA English
DT Article
DE Abdominal obesity; Bipolar disorder; Major depressive disorder;
   Metabolic syndrome; Psychotropic drugs
ID SYMPTOMATOLOGY IDS; INCREASED RISK; PREVALENCE; NETHERLANDS; ANXIETY;
   OBESITY; BURDEN; HEALTH; ABNORMALITIES; POLYMORPHISMS
AB Objective: We aimed to investigate the prevalence of the metabolic syndrome (MetS) and its individual components in subjects with bipolar disorder (BD) compared to those with major depressive disorder (MDD) and non-psychiatric controls.
   Methods: We examined 2431 participants (mean age 443 +/- 13.0,66.1% female), of whom 241 had BD; 1648 had MDD; and 542 were non-psychiatric controls. The MetS was ascertained according to NCEP ATP III criteria. Multivariable analyses were adjusted for age, sex, ethnicity, level of education, smoking status and severity of depressive symptoms, and in the case of BD subjects, also for psychotropic medication use.
   Results: Subjects with BD had a significantly higher prevalence of MetS when compared to subjects with MDD and non-psychiatric controls (28.4% vs. 20.2% and 16.5%, respectively, p < 0.001), also when adjusted for sociodemographic and lifestyle factors (OR 1.52, 95% CI: 1.09-232, p = 0.02 compared to MDD; OR 1.79, 95% CI: 1.20-2.67, p = 0.005 compared to non-psychiatric controls). The differences between BD subjects with controls could partly be ascribed to a higher mean waist circumference (91.0 cm vs. 88.8, respectively, p = 0.03). In stratified analysis, the differences in the prevalence of MetS between patients with BD and MDD were found in symptomatic but not in asymptomatic cases.
   Conclusion: This study confirms a higher prevalence of MetS in patients with BD compared to both MDD patients and controls. Specifically at risk are patients with a higher depression score and abdominal obesity. (C) 2015 Elsevier Inc. All rights reserved.
C1 [Silarova, Barbora; Spijker, Annet T.] PsyQ, Dept Mood Disorders, NL-3062 MA Rotterdam, Netherlands.
   [Giltay, Erik J.; Penninx, Brenda W. J. H.] Leiden Univ, Med Ctr, Dept Psychiat, Leiden, Netherlands.
   [Dortland, Arianne Van Reedt] Vrije Univ Amsterdam, Med Ctr, GGZinGeest, Amsterdam, Netherlands.
   [Van Rossum, Elisabeth F. C.] Erasmus MC, Dept Internal Med, Rotterdam, Netherlands.
   [Hoencamp, Erik] Parnassia Grp, The Hague, Netherlands.
   [Hoencamp, Erik] Leiden Univ, Inst Psychol, Leiden, Netherlands.
   [Penninx, Brenda W. J. H.] Vrije Univ Amsterdam, Med Ctr, Dept Psychiat, Amsterdam, Netherlands.
   [Penninx, Brenda W. J. H.] Vrije Univ Amsterdam, Med Ctr, EMGO Inst Hlth & Care Res, Amsterdam, Netherlands.
   [Penninx, Brenda W. J. H.] Univ Groningen, Univ Med Ctr Groningen, Dept Psychiat, NL-9713 AV Groningen, Netherlands.
C3 Leiden University; Leiden University Medical Center (LUMC); Leiden
   University - Excl LUMC; Vrije Universiteit Amsterdam; Erasmus University
   Rotterdam; Erasmus MC; Parnassia Psychiatric Institute; Leiden
   University; Leiden University - Excl LUMC; Vrije Universiteit Amsterdam;
   Vrije Universiteit Amsterdam; University of Groningen
RP Silarova, B (corresponding author), PsyQ, Dept Mood Disorders, Max Euwelaan 60-80, NL-3062 MA Rotterdam, Netherlands.
EM silarova.barbora@gmail.com
RI Penninx, Brenda/S-7627-2017; Giltay, Erik/AAL-9948-2021; van Rossum,
   Elisabeth/AAP-9388-2020
OI Giltay, Erik J./0000-0001-8874-2292; van Rossum,
   Elisabeth/0000-0003-0120-4913
FU Netherlands Organization for Health Research and Development (ZonMw)
   [10-000-1002]; VU University Medical Center; GGZinGeest; Arkin; Leiden
   University Medical Center; GGZ Rivierduinen; University Medical Center
   Groningen; Lentis; GGZ Friesland; GGZ Drenthe; Scientific Institute for
   Quality of Health Care (IQHealthcare); Netherlands Institute for Health
   Services Research (NIVEL); Netherlands Institute of Mental Health and
   Addiction (Trimbos)
FX The infrastructure for the NESDA study (www.nesda.nl) is funded through
   the Geestkracht program of the Netherlands Organization for Health
   Research and Development (ZonMw, grant number 10-000-1002) and is
   supported by participating universities and mental health care
   organizations (VU University Medical Center, GGZinGeest, Arkin, Leiden
   University Medical Center, GGZ Rivierduinen, University Medical Center
   Groningen, Lentis, GGZ Friesland, GGZ Drenthe, Scientific Institute for
   Quality of Health Care (IQHealthcare), Netherlands Institute for Health
   Services Research (NIVEL) and Netherlands Institute of Mental Health and
   Addiction (Trimbos).
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NR 49
TC 33
Z9 38
U1 0
U2 14
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-3999
EI 1879-1360
J9 J PSYCHOSOM RES
JI J. Psychosomat. Res.
PD APR
PY 2015
VL 78
IS 4
BP 391
EP 398
DI 10.1016/j.jpsychores.2015.02.010
PG 8
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA CE8VG
UT WOS:000352121600014
PM 25742722
OA hybrid
DA 2025-06-11
ER

PT J
AU Péterfalvi, A
   Németh, N
   Herczeg, R
   Tényi, T
   Miseta, A
   Czéh, B
   Simon, M
AF Peterfalvi, Agnes
   Nemeth, Nandor
   Herczeg, Robert
   Tenyi, Tamas
   Miseta, Attila
   Czeh, Boldizsar
   Simon, Maria
TI Examining the Influence of Early Life Stress on Serum Lipid Profiles and
   Cognitive Functioning in Depressed Patients
SO FRONTIERS IN PSYCHOLOGY
LA English
DT Article
DE adverse childhood experience; childhood adversity; cardiovascular risk;
   cholesterol; depression; HDL; major depressive disorder; triglyceride
ID CARDIOVASCULAR RISK-FACTORS; HIGH-DENSITY-LIPOPROTEIN; ADVERSE CHILDHOOD
   EXPERIENCES; LOW HDL CHOLESTEROL; METABOLIC SYNDROME; MAJOR DEPRESSION;
   SEXUAL-ABUSE; SOCIAL DESIRABILITY; CARDIAC MORTALITY; BIPOLAR DISORDER
AB Background: Early childhood adversity is a strong predictor of the development of major depressive disorder (MDD), but not all depressed patients experience early life stress (ELS). Cardio-metabolic diseases and cognitive deficits often coincide in MDD and worsen its course and outcome. Adverse childhood experiences have been associated with elevated risk for cardiovascular disease (CVD), but little is known on the impact of ELS on cardiovascular risk factors in MDD. Here, we examined MDD patients with and without ELS to explore the effects of ELS on serum lipid and lipoprotein levels and on cognitive performances of the patients.
   Methods: Participants with a mean age of 35 years (18-55 years) were recruited from the university mental health clinic and general community. Three groups, matched in age, gender and lifestyle were examined: MDD patients with ELS (n = 21), MDD patients without ELS (n = 21), and healthy controls (n = 20). The following CVD risk factors were assessed: serum lipids (total cholesterol, triglycerides, high- and low-density lipoproteins), body mass index and exercise in a typical week. MDD severity was measured by the Beck Depression Inventory. Childhood Trauma Questionnaire was used to assess early life adversities. Executive functions and attentional processes were assessed by the Wisconsin Card Sorting and Conners' Continuous Performance tests.
   Results: Major depressive disorder patients with ELS had higher serum triglyceride and lower HDL-cholesterol concentrations compared to MDD patients without ELS. Linear regression analysis revealed that the severity of ELS had a significant negative association with HDL-cholesterol levels and significant positive associations with the serum levels of TG and TC/HDL-cholesterol index. We also found significant associations between some specific trauma types and lipid profiles. Finally, we could detect significant associations between depression severity and specific domains of the cognitive tests as well as between lipid profiles and certain domains of the Wisconsin Card Sorting Test. However, we could not detect any association between the severity of ELS and cognitive performance.
   Conclusion: After controlling for depressive symptom severity and lifestyle variables, ELS was found to be a strong predictor of serum lipid alterations. Several, inter-correlated pathways may mediate the undesirable effects of ELS on the course and outcome of MDD.
C1 [Peterfalvi, Agnes; Nemeth, Nandor; Czeh, Boldizsar; Simon, Maria] Univ Pecs, Szentagothai Res Ctr, Neurobiol Stress Res Grp, Pecs, Hungary.
   [Peterfalvi, Agnes; Miseta, Attila; Czeh, Boldizsar] Univ Pecs, Med Sch, Dept Lab Med, Pecs, Hungary.
   [Herczeg, Robert] Univ Pecs, Szentagothai Res Ctr, Bioinformat Res Grp, Pecs, Hungary.
   [Tenyi, Tamas; Simon, Maria] Univ Pecs, Med Sch, Dept Psychiat & Psychotherapy, Pecs, Hungary.
C3 University of Pecs; University of Pecs; University of Pecs; University
   of Pecs
RP Simon, M (corresponding author), Univ Pecs, Szentagothai Res Ctr, Neurobiol Stress Res Grp, Pecs, Hungary.; Simon, M (corresponding author), Univ Pecs, Med Sch, Dept Psychiat & Psychotherapy, Pecs, Hungary.
EM simon.maria@pte.hu
RI Czeh, Boldizsar/ABB-6563-2020
OI Czeh, Boldizsar/0000-0002-4926-5400; Nandor, Nemeth/0000-0002-4379-036X
FU EU Social Funds [EFOP-3.6.3-VEKOP-16-2017-00009,
   EFOP-3.6.2-16-2017-00008, GINOP-2.3.2.-15-2016-00050]; Hungarian Brain
   Research Program [KTIA_NAP_13-2-2014-0019, 20017-1.2.1-NKP-2017-00002];
   Higher Education Institutional Excellence Programme of the Ministry of
   Human Capacities in Hungary; Medical School of the University of Pecs
FX This work was financially supported by the following grant agencies: EU
   Social Funds (EFOP-3.6.3-VEKOP-16-2017-00009 and
   EFOP-3.6.2-16-2017-00008, "The role of neuroinflammation in
   neurodegeneration: from molecules to clinics" and
   GINOP-2.3.2.-15-2016-00050, "PEPSYS"), the Hungarian Brain Research
   Program (KTIA_NAP_13-2-2014-0019 and 20017-1.2.1-NKP-2017-00002), and
   The Higher Education Institutional Excellence Programme of the Ministry
   of Human Capacities in Hungary, within the framework of the
   20765-3/2018/FEKUTSTRAT 5th thematic program of the University of Pecs.
   Further financial support was received from the Medical School of the
   University of Pecs. These grant agencies had no influence on study
   design; on the collection, analysis, and interpretation of data; on the
   writing of the report; and on the decision to submit the article for
   publication.
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NR 148
TC 24
Z9 25
U1 0
U2 15
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-1078
J9 FRONT PSYCHOL
JI Front. Psychol.
PD AUG 6
PY 2019
VL 10
AR 1798
DI 10.3389/fpsyg.2019.01798
PG 16
WC Psychology, Multidisciplinary
WE Social Science Citation Index (SSCI)
SC Psychology
GA IN9BV
UT WOS:000478974700001
PM 31447737
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Chase, B
   Brusseau, T
   Burns, R
   Hannon, J
   Henderson, H
   Kehoe, B
AF Chase, Benjamin
   Brusseau, Timothy
   Burns, Ryan
   Hannon, James
   Henderson, Hester
   Kehoe, Brian
TI Association between health-related fitness, perceived stress, and
   metabolic syndrome prevalence in a sample of law enforcement officers
SO POLICING-AN INTERNATIONAL JOURNAL OF POLICE STRATEGIES & MANAGEMENT
LA English
DT Article
DE Stress; Police; Law enforcement; Physical fitness; Metabolic syndrome
ID CARDIORESPIRATORY FITNESS; PHYSICAL-ACTIVITY; POLICE OFFICERS;
   CARDIOVASCULAR-DISEASE; EXERCISE; RISK; MORTALITY; PERSONNEL; ADULTS;
   TESTS
AB Purpose - The purpose of this study is to examine the association between components of metabolic syndrome with health-related fitness (HRF) and perceived stress in a sample of law enforcement officers.
   Design/methodology/approach - Law enforcement officers (N = 28) from the Mountain West region of the US reported their HRF scores (1.5 mile run, push-up, and sit-ups), had their blood drawn (glucose, triglycerides, high-density lipoprotein (HDL)) and had their waist circumference and blood pressure measured in a fasted state. Officers also completed a short questionnaire to assess health-enhancing physical activity (SQUASH) and both the Organizational and Operational Police Stress Questionnaires (PSQ-Org, PSQ-Op).
   Findings - Linear regression models revealed a positive linear relationship between glucose levels and 1.5 mile run times (beta = 0.560, p = 0.021, R-2 = 0.24). A bivariate positive linear relationship between waist circumference and 1.5 mile run times was found to be significant (R-2 = 0.17, p = 0.041). For every minute increase in 1.5-mile run times, PSQ-Org scores significantly increased by 0.543 standard deviations (p = 0.022) with 25% of the variance explained (R-2 = 0.25). There were no statistically significant parameter estimates from the logistic regression equations when dependent variables were treated on the categorical measurement scale using recommended cut-points.
   Research limitations/implications In conclusion, those who performed better on the 1.5 mile run were more likely to have lower fasting glucose levels, experience less stress and have a smaller waist circumference.
   Practical implications - Therefore, according to these findings, it is imperative for those in law enforcement to improve their cardiorespiratory endurance to minimize stress and reduce their risk of metabolic syndrome.
   Originality/value - This research is novel according to a recent PubMed search using the keywords "law enforcement," "Metabolic Syndrome" and "fitness testing."
C1 [Chase, Benjamin] Brigham Young Univ Hawaii, Exercise & Sport Sci, Laie, HI 96762 USA.
   [Brusseau, Timothy; Burns, Ryan] Univ Utah Hlth, Hlth Kinesiol & Recreat, Salt Lake City, UT USA.
   [Hannon, James] Kent State Univ, Kent, OH 44242 USA.
   [Henderson, Hester] Univ Utah Hlth, Salt Lake City, UT USA.
   [Kehoe, Brian] FSU, Tallahassee, FL USA.
C3 Brigham Young University; Brigham Young University - Hawaii; Utah System
   of Higher Education; University of Utah; University System of Ohio; Kent
   State University; Kent State University Kent; Kent State University
   Salem; Utah System of Higher Education; University of Utah; State
   University System of Florida; Florida State University
RP Chase, B (corresponding author), Brigham Young Univ Hawaii, Exercise & Sport Sci, Laie, HI 96762 USA.
EM benjamin.chase@byuh.edu; tim.brusseau@utah.edu; ryan.d.burns@utah.edu;
   jhannon5@kent.edu; hester.henderson@health.utah.edu;
   drbriankehoe@gmail.com
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NR 60
TC 1
Z9 1
U1 0
U2 7
PU EMERALD GROUP PUBLISHING LTD
PI BINGLEY
PA HOWARD HOUSE, WAGON LANE, BINGLEY BD16 1WA, W YORKSHIRE, ENGLAND
SN 1363-951X
EI 1758-695X
J9 POLICING
JI Policing-An Int J Police Strategies & Manag.
PD MAR 19
PY 2021
VL 44
IS 2
SI SI
BP 261
EP 274
DI 10.1108/PIJPSM-04-2020-0058
EA FEB 2021
PG 14
WC Criminology & Penology
WE Social Science Citation Index (SSCI)
SC Criminology & Penology
GA RA8FR
UT WOS:000616016900001
DA 2025-06-11
ER

PT J
AU Vilarrasa, N
   San Jose, P
   Rubio, MA
   Lecube, A
AF Vilarrasa, Nuria
   San Jose, Patricia
   Rubio, Miguel Angel
   Lecube, Albert
TI Obesity in Patients with Type 1 Diabetes: Links, Risks and Management
   Challenges
SO DIABETES METABOLIC SYNDROME AND OBESITY
LA English
DT Review
DE obesity; type 1 diabetes; dual diabetes; insulin resistance; metabolic
   syndrome; bariatric surgery
ID GASTRIC BYPASS-SURGERY; LOW-CARBOHYDRATE-DIET; CONTROLLED-RELEASE
   PHENTERMINE/TOPIRAMATE; BARIATRIC SURGERY; DOUBLE-BLIND; WEIGHT-LOSS;
   METABOLIC SYNDROME; GLYCEMIC CONTROL; CONTROLLED-TRIAL; BODY-WEIGHT
AB Obesity affects large numbers of patients with type 1 diabetes (T1D) across their lifetime, with rates ranging between 2.8% and 37.1%. Patients with T1D and obesity are characterized by the presence of insulin resistance, of high insulin requirements, have a greater cardiometabolic risk and an enhanced risk of developing chronic complications when compared to normal-weight persons with T1D. Dual treatment of obesity and T1D is challenging and no specific guidelines for improving outcomes of both glycemic control and weight management have been established for this population. Nevertheless, although evidence is scarce, a comprehensive approach based on a balanced hypocaloric diet, physical activity and cognitive behavioral therapy by a multidisciplinary team, expert in both obesity and diabetes, remains as the best clinical practice. However, weight loss responses with lifestyle changes alone are limited, so in the "roadmap" of the treatment of obesity in T1D, it will be helpful to include anti-obesity pharmacotherapy despite at present there is a lack of evidence since T1D patients have been excluded from anti-obesity drug clinical trials. In case of severe obesity, bariatric surgery has proven to be of benefit in obtaining a substantial and long-term weight loss and reduction in cardiovascular risk. The near future looks promising with the development of new and more effective anti-obesity treatments and strategies to improve insulin resistance and oxidative stress. Advances in precision medicine may help individualize and optimize the medical management and care of these patients. This review, by gathering current evidence, highlights the need of solid knowledge in all facets of the treatment of patients with obesity and T1D that can only be obtained through high quality well-designed studies.
C1 [Vilarrasa, Nuria; San Jose, Patricia] Hosp Univ Bellvitge IDIBELL, Dept Endocrinol & Nutr, Barcelona, Spain.
   [Vilarrasa, Nuria; Lecube, Albert] Inst Salud Carlos III, CIBERDEM CIBER Diabet & Enfermedades Metab Asocia, Madrid, Spain.
   [Rubio, Miguel Angel] Hosp Clin San Carlos, IDISSC, Dept Endocrinol & Nutr, Madrid 28040, Spain.
   [Lecube, Albert] Hosp Arnau Vilanova, Endocrinol & Nutr Dept, Lleida 25198, Spain.
   [Lecube, Albert] Univ Lleida, Inst Recerca Biomed Lleida IRBLIeida, Obes Diabet & Metab ODIM Res Grp, Lleida, Spain.
C3 Institut d'Investigacio Biomedica de Bellvitge (IDIBELL); Bellvitge
   University Hospital; CIBER - Centro de Investigacion Biomedica en Red;
   CIBERDEM; Instituto de Salud Carlos III; Hospital Clinico San Carlos;
   University Hospital Arnau de Vilanova; Universitat de Lleida; Institut
   de Recerca Biomedica - IRB Lleida
RP Vilarrasa, N (corresponding author), Hosp Univ Bellvitge IDIBELL, C Feixa Llarga S-N, Barcelona 08907, Spain.
EM nuriavilarrasa@yahoo.es
RI Vilarrasa, Nuria/AFV-3241-2022; Rubio, Miguel Angel/GRJ-0134-2022;
   Lecube, Albert/H-3813-2019
OI Vilarrasa, Nuria/0000-0003-3188-1990; Rubio, Miguel
   A./0000-0002-0495-6240
FU Ajuts per a projectes de recerca clinica de L'Hospital Universitari de
   Bellvitge [2011-PR143/11]; Instituto de Salud Carlos III [PI11/01960,
   PI14/01997, PI17/01556, CB07708/0012]; European Union (ERDF, "A way to
   build Europe");  [PI18/00964]
FX NV is the recipient of grants "Ajuts per a projectes de recerca clinica
   de L'Hospital Universitari de Bellvitge (2011-PR143/11)" and of the
   project "PI11/01960; PI14/01997 and PI17/01556" funded by the Instituto
   de Salud Carlos III and co-funded by the European Union (ERDF, "A way to
   build Europe"). AL is the recipient of grant PI18/00964. The Spanish
   Biomedical Research Center in Diabetes and Associated Metabolic
   Disorders (CIBERDEM) (CB07708/0012) is an initiative of the Instituto de
   Salud Carlos III.
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NR 180
TC 47
Z9 47
U1 2
U2 8
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-7007
J9 DIABET METAB SYND OB
JI Diabetes Metab. Syndr. Obes.
PY 2021
VL 14
BP 2807
EP 2827
DI 10.2147/DMSO.S223618
PG 21
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA SW4RK
UT WOS:000664504000001
PM 34188505
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Flores, K
   Almeida, C
   Arriaza, K
   Pena, E
   El Alam, S
AF Flores, Karen
   Almeida, Carlo
   Arriaza, Karem
   Pena, Eduardo
   El Alam, Samia
TI mTOR in the Development of Hypoxic Pulmonary Hypertension Associated
   with Cardiometabolic Risk Factors
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE hypoxic pulmonary hypertension; mTOR; cardiometabolic risk factors
ID ACTIVATED PROTEIN-KINASE; OBSTRUCTIVE SLEEP-APNEA; LINKING
   INSULIN-RESISTANCE; MAMMALIAN TARGET; OXIDATIVE STRESS;
   PHOSPHATIDYLINOSITOL 3-KINASE; VASCULAR ENDOTHELIUM;
   MOLECULAR-MECHANISMS; INTERMITTENT HYPOXIA; LIPID-ACCUMULATION
AB The pathophysiology of pulmonary hypertension is complex and multifactorial. It is a disease characterized by increased pulmonary vascular resistance at the level due to sustained vasoconstriction and remodeling of the pulmonary arteries, which triggers an increase in the mean pulmonary artery pressure and subsequent right ventricular hypertrophy, which in some cases can cause right heart failure. Hypoxic pulmonary hypertension (HPH) is currently classified into Group 3 of the five different groups of pulmonary hypertensions, which are determined according to the cause of the disease. HPH mainly develops as a product of lung diseases, among the most prevalent causes of obstructive sleep apnea (OSA), chronic obstructive pulmonary disease (COPD), or hypobaric hypoxia due to exposure to high altitudes. Additionally, cardiometabolic risk factors converge on molecular mechanisms involving overactivation of the mammalian target of rapamycin (mTOR), which correspond to a central axis in the development of HPH. The aim of this review is to summarize the role of mTOR in the development of HPH associated with metabolic risk factors and its therapeutic alternatives, which will be discussed in this review.
C1 [Flores, Karen; Almeida, Carlo; Arriaza, Karem; Pena, Eduardo; El Alam, Samia] Arturo Prat Univ, High Altitude Med Res Ctr CEIMA, Iquique 1110939, Chile.
C3 Universidad Arturo Prat
RP Arriaza, K (corresponding author), Arturo Prat Univ, High Altitude Med Res Ctr CEIMA, Iquique 1110939, Chile.
EM kfloresu@unap.cl; calmeida.biotec@gmail.com; karriaza@unap.cl;
   eduardopena@unap.cl; selalam@unap.cl
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NR 184
TC 0
Z9 0
U1 6
U2 11
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD OCT
PY 2024
VL 25
IS 20
AR 11023
DI 10.3390/ijms252011023
PG 18
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA K1C3N
UT WOS:001341328300001
PM 39456805
OA gold
DA 2025-06-11
ER

PT J
AU Somi, M
   Zakavi, SS
   Ostadrahimi, A
   Frounchi, N
   Gilani, N
   Sanaie, S
   Faramarzi, E
AF Somi, Mohammadhossein
   Zakavi, Seyed Sina
   Ostadrahimi, Alireza
   Frounchi, Negin
   Gilani, Neda
   Sanaie, Sarvin
   Faramarzi, Elnaz
TI Can Gamma-glutamyl Transferase Predict Unhealthy Metabolic Phenotypes
   Among Healthcare Workers in Azar Cohort Study?
SO HEPATITIS MONTHLY
LA English
DT Article
DE Cardiometabolic Phenotype; Gamma Glutamyl Transferase; Cohort Study;
   Metabolic Syndrome
ID ATHEROSCLEROSIS RISK; OXIDATIVE STRESS; GLUTAMYLTRANSFERASE;
   ASSOCIATION; OBESE; COMPONENTS
AB Background: Although various studies have assessed the correlation between gamma-glutamyl transferase (GGT) and cardiometabolic risk factors in obesity, no research has differentiated among metabolically-healthy obese (MHO) and metabolically unhealthy obese (MUHO), metabolically-healthy lean (MHL), and metabolically-unhealthy lean (MUHL).
   Objectives: Accordingly, this study evaluated the correlation between GGT and cardiometabolic phenotypes among healthcare workers.
   Methods: In this study, there were anthropometric measurements as well as the measurements of fasting blood sugar (FBS), GGT, cholesterol, triglyceride (TG), high lipoprotein density (HDL), and blood pressure in 1458 healthcare workers enrolled in the Azar Cohort Study. Metabolic syndrome (MetS) was defined according to the National Cholesterol Education Program Adult Treatment Panel III (ATP III). Accordingly, the participants were divided into four cardiometabolic phenotypes. Results: In this cross-sectional study, there was a significant difference in the prevalence of cardiometabolic phenotypes regarding the GGT tertiles (P <= 0.001). The highest prevalence of MHO was observed in the third GGT tertile. The mean waist circumference, TG, FBS, HDL, and systolic and diastolic blood pressure levels increased in the MHO, MUHO, and MHL groups in a dose dependent manner with an increase in the GGT tertiles (P < 0.05). In comparing the highest and lowest GGT tertile, the risk of MHO and MUHO increased by 2.84 (95%CI 2.01 - 4.01) and 9.12 (95%CI 5.54 - 15), respectively. However, the correlation between the GGT tertile and MUHL did not reveal a similar trend. The ROC curve shows the cutoff value of 18.5 U/L for GGT, which allowed us to distinguish between the MUHO and MHO individuals.
   Conclusions: The findings revealed that GGT can indicate the risk of MetS as such, it can be used to detect at-risk MHO individuals and administer proper interventions.
C1 [Somi, Mohammadhossein; Faramarzi, Elnaz] Tabriz Univ Med Sci, Liver & Gastrointestinal Dis Resaerch Ctr, Tabriz, Iran.
   [Zakavi, Seyed Sina; Frounchi, Negin] Tabriz Univ Med Sci, Student Res Comm, Tabriz, Iran.
   [Ostadrahimi, Alireza] Tabriz Univ Med Sci, Nutr Resaerch Ctr, Tabriz, Iran.
   [Gilani, Neda] Tabriz Univ Med Sci, Fac Hlth, Dept Stat & Epidemiol, Tabriz, Iran.
   [Sanaie, Sarvin] Tabriz Univ Med Sci, Neurosci Res Ctr, Tabriz, Iran.
C3 Tabriz University of Medical Science; Tabriz University of Medical
   Science; Tabriz University of Medical Science; Tabriz University of
   Medical Science; Tabriz University of Medical Science
RP Faramarzi, E (corresponding author), Tabriz Univ Med Sci, Liver & Gastrointestinal Dis Resaerch Ctr, Tabriz, Iran.; Sanaie, S (corresponding author), Tabriz Univ Med Sci, Liver & Gastrointestinal Dis Res Ctr, Tabriz, Iran.
EM sarvin_so2000@yahoo.com; elnazfaramarzi849@gmail.com
RI Gilani, Neda/D-7715-2017; Faramarzi, Elnaz/A-3648-2012; Sanaie,
   Sarvin/I-3769-2016; Zakavi, Seyed Sina/JUV-2515-2023
OI Faramarzi, Elnaz/0000-0003-4128-433X; Sanaie,
   Sarvin/0000-0003-2325-5631; Zakavi, Seyed Sina/0000-0002-3775-3888
FU Research Center for Liver and Gastrointestinal Diseases [67753]; Tabriz
   University of Medical Sciences
FX This study was supported by the Research Center for Liver and
   Gastrointestinal Diseases (Grant NO.: 67753), Tabriz University of
   Medical Sciences. Informed Consent: Written informed consent was
   obtained from all participants.
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NR 36
TC 0
Z9 0
U1 0
U2 2
PU BRIEFLANDS
PI Shertogenbosch
PA 25 Derde Morgen, Shertogenbosch, NETHERLANDS
SN 1735-143X
EI 1735-3408
J9 HEPAT MON
JI Hepat. Mon.
PD DEC
PY 2022
VL 22
IS 1
AR e121021
DI 10.5812/hepatmon-121021
PG 9
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 6J4DH
UT WOS:000886774200001
OA gold
DA 2025-06-11
ER

PT J
AU Peng, P
   Wang, QJ
   Zhou, YA
   Hao, YZ
   Chen, SB
   Wu, QX
   Li, MY
   Wang, YF
   Yang, Q
   Wang, X
   Liu, YH
   Ma, YJ
   He, L
   Xu, HX
   Li, ZJ
   Lang, XE
   Liu, TQ
   Zhang, XY
AF Peng, Pu
   Wang, Qianjin
   Zhou, Yanan
   Hao, Yuzhu
   Chen, Shubao
   Wu, Qiuxia
   Li, Manyun
   Wang, Yunfei
   Yang, Qian
   Wang, Xin
   Liu, Yueheng
   Ma, Yuejiao
   He, Li
   Xu, Huixue
   Li, Zejun
   Lang, XiaoE
   Liu, Tieqiao
   Zhang, Xiangyang
TI Association of subclinical hypothyroidism with metabolic syndrome and
   its components among outpatients with first-episode drug-naive major
   depressive disorder: a large-scale cross-sectional study
SO EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
LA English
DT Article
DE Major depressive disorder; Metabolic syndrome; Subclinical
   hypothyroidism
ID TRIGLYCERIDE LEVELS; METAANALYSIS; POPULATION; SEVERITY; DISEASE;
   INFLAMMATION; PREVALENCE
AB Both metabolic syndrome (MetS) and subclinical hypothyroidism (SCH) are prevalent in major depressive disorder (MDD) patients. However, their relationship in this population remains unknown. The study assessed the association between SCH and MetS in 1706 first-episode drug-naive (FEDN) MDD patients. We also compared the relationship between MetS and clinical symptoms in patients with and without comorbid SCH. The Positive and Negative Syndrome Scale positive subscale, the Hamilton Anxiety Rating Scale, and the Hamilton Depression Rating Scale were used to detect clinical symptoms. Serum levels of free triiodothyronine, free thyroxine, thyroid stimulating hormone (TSH), anti-thyroglobulin, thyroid peroxidases antibody, cholesterol, triglycerides, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and fasting glucose were measured. The Area Under the Curve (AUC) was used to test the performance of serum TSH in identifying MetS patients. The prevalence of MetS and SCH was 34.5% (n = 585) and 61% (n = 1034), respectively. The presence of SCH increased the risk of MetS, hyperglycemia, hypertension, obesity, and low HDL-C by 4.91, 3.51, 3.54, 2.02, and 2.34 times, respectively. Serum TSH had a nice ability to distinguish MetS patients from non-MetS patients (AUC value = 0.77). MetS and its components exhibited a positive association with clinical profiles only in SCH patients, but not in non-SCH patients. Taken together, our study suggested SCH was closely related to MetS and might play a vital role in the relationship between MetS and clinical symptoms. Regular thyroid function checks might help early detect MetS.
C1 [Peng, Pu; Wang, Qianjin; Hao, Yuzhu; Chen, Shubao; Wu, Qiuxia; Li, Manyun; Wang, Yunfei; Yang, Qian; Wang, Xin; Liu, Yueheng; Ma, Yuejiao; He, Li; Xu, Huixue; Li, Zejun; Liu, Tieqiao] Cent South Univ, Xiangya Hosp 2, Dept Psychiat, Changsha, Hunan, Peoples R China.
   [Peng, Pu; Wang, Qianjin; Hao, Yuzhu; Chen, Shubao; Wu, Qiuxia; Li, Manyun; Wang, Yunfei; Yang, Qian; Wang, Xin; Liu, Yueheng; Ma, Yuejiao; He, Li; Xu, Huixue; Li, Zejun; Liu, Tieqiao] Cent South Univ, Xiangya Hosp 2, Natl Clin Res Ctr Mental Disorders, Changsha, Hunan, Peoples R China.
   [Zhou, Yanan] Hunan Brain Hosp, Hunan Peoples Hosp 2, Dept Psychiat, Changsha, Peoples R China.
   [Lang, XiaoE] Shanxi Med Univ, Hosp 1, Dept Psychiat, Taiyuan, Peoples R China.
   [Zhang, Xiangyang] Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China.
   [Zhang, Xiangyang] Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China.
C3 Central South University; Central South University; Shanxi Medical
   University; Chinese Academy of Sciences; Institute of Psychology, CAS;
   Chinese Academy of Sciences; University of Chinese Academy of Sciences,
   CAS
RP Liu, TQ (corresponding author), Cent South Univ, Xiangya Hosp 2, Dept Psychiat, Changsha, Hunan, Peoples R China.; Liu, TQ (corresponding author), Cent South Univ, Xiangya Hosp 2, Natl Clin Res Ctr Mental Disorders, Changsha, Hunan, Peoples R China.; Zhang, XY (corresponding author), Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China.; Zhang, XY (corresponding author), Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China.
EM liutieqiao123@csu.edu.cn; zhangxy@psych.ac.cn
RI wang, qianjin/KLD-6415-2024; xiang, yan/KIG-7705-2024; Zhang,
   Xiangyang/ABC-7380-2022; Wang, Yunfei/GLU-3258-2022; li,
   zejun/HTP-2912-2023; cheng, shu/IZE-4788-2023; Zhang,
   Jiajia/ABB-6049-2020; Chen, Shubao/AAF-9310-2019; liu,
   tieqiao/GSE-2327-2022
OI Peng, Pu/0000-0002-4180-7252; Zhang, Xiangyang/0000-0003-3326-382X
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NR 51
TC 8
Z9 8
U1 0
U2 9
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0940-1334
EI 1433-8491
J9 EUR ARCH PSY CLIN N
JI Eur. Arch. Psych. Clin. Neurosci.
PD APR
PY 2024
VL 274
IS 3
BP 573
EP 582
DI 10.1007/s00406-023-01588-9
EA MAR 2023
PG 10
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Psychiatry
GA NB1P9
UT WOS:000955956300001
PM 36961565
DA 2025-06-11
ER

PT J
AU Tang, KR
   Mo, XW
   Zhou, XY
   Chen, YY
   Liu, DD
   He, LL
   Ma, QY
   Li, XJ
   Chen, JX
AF Tang, Kai-rui
   Mo, Xiao-wei
   Zhou, Xing-yi
   Chen, Yue-yue
   Liu, Dong-dong
   He, Liang-liang
   Ma, Qing-yu
   Li, Xiao-juan
   Chen, Jia-xu
TI Xiaoyao San, a Chinese herbal formula, ameliorates depression-like
   behavior in mice through the AdipoR1/AMPK/ACC pathway in hypothalamus
SO JOURNAL OF INTEGRATIVE MEDICINE-JIM
LA English
DT Article
DE Depression; Xiaoyao San; Chronic social defeat stress; Adiponectin;
   Adiponectin receptor 1; Glucose metabolism disorders
ID METABOLIC SYNDROME; ADIPONECTIN; STRESS; AXIS; AMPK; LEPTIN
AB Objective: Depression and metabolic disorders have overlapping psychosocial and pathophysiological causes. Current research is focused on the possible role of adiponectin in regulating common biological mechanisms. Xiaoyao San (XYS), a classic Chinese medicine compound, has been widely used in the treat-ment of depression and can alleviate metabolic disorders such as lipid or glucose metabolism disorders. However, the ability of XYS to ameliorate depression-like behavior as well as metabolic dysfunction in mice and the underlying mechanisms are unclear. Methods: An in vivo animal model of depression was established by chronic social defeat stress (CSDS). XYS and fluoxetine were administered by gavage to the drug intervention group. Depression-like behav-iors were analyzed by the social interaction test, open field test, forced swim test, and elevated plus maze test. Glucose levels were measured using the oral glucose tolerance test. The involvement of certain molecules was validated by immunofluorescence, histopathology, and Western blotting. In vitro, hypothalamic primary neurons were exposed to high glucose to induce neuronal damage, and the neu-roprotective effect of XYS was evaluated by cell counting kit-8 assay. Immunofluorescence and Western blotting were used to evaluate the influences of XYS on adiponectin receptor 1 (AdipoR1), adenosine 50- monophosphate-activated protein kinase (AMPK), acetyl-coenzyme A carboxylase (ACC) and other related proteins. Results: XYS ameliorated CSDS-induced depression-like behaviors and glucose tolerance impairment in mice and increased the level of serum adiponectin. XYS also restored Nissl bodies in hypothalamic neu-rons in mice that exhibited depression-like behaviors and decreased the degree of neuronal morpholog-ical damage. In vivo and in vitro studies indicated that XYS increased the expression of AdipoR1 in hypothalamic neurons. Conclusion: Adiponectin may be a key regulator linking depression and metabolic disorders; regulation of the hypothalamic AdipoR1/AMPK/ACC pathway plays an important role in treatment of depression by XYS. (C) 2022 Shanghai Yueyang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine. Published by Elsevier B.V.
C1 [Tang, Kai-rui; Mo, Xiao-wei; Zhou, Xing-yi; Chen, Yue-yue; Liu, Dong-dong; Ma, Qing-yu; Li, Xiao-juan; Chen, Jia-xu] Jinan Univ, Sch Tradit Chinese Med, Guangzhou Key Lab Formula Pattern Tradit Chinese M, Guangzhou 510632, Guangdong Provi, Peoples R China.
   [He, Liang-liang] Jinan Univ, Coll Pharm, Guangzhou 510632, Guangdong Provi, Peoples R China.
C3 Jinan University; Jinan University
RP Li, XJ; Chen, JX (corresponding author), Jinan Univ, Sch Tradit Chinese Med, Guangzhou Key Lab Formula Pattern Tradit Chinese M, Guangzhou 510632, Guangdong Provi, Peoples R China.
EM lixiaojuan@jnu.edu.cn; chenjiaxu@hotmail.com
RI chen, jiaojiao/KII-6749-2024; Liu, Dongdong/JEZ-6451-2023; Tang,
   Kairui/HTQ-0082-2023; Chen, Yueyue/MAH-5936-2025; Zhou,
   Xuyang/ABG-9741-2021
FU National Natural Science Foundation of China [81904091, 81973748,
   82174278]; National Natural Science Foundation of Guangdong, China
   [2021A1515011212]; Province Scientific Research Project of Traditional
   Chinese Medicine Bureau of Guangdong [20202039]; Development Program of
   Guangdong Province [2020B1111100001]; Guangzhou Key Laboratory of
   Formula-Pattern of Traditional Chinese Medicine, China
FX This work was financially supported by the National Natural Science
   Foundation of China (No. 81904091, No. 81973748 and No. 82174278) , the
   National Natural Science Foundation of Guang-dong, China (No.
   2021A1515011212) , Province Scientific Research Project of Traditional
   Chinese Medicine Bureau of Guangdong (No. 20202039) , Huang Zhendong
   Research Fund for Traditional Chinese Medicine of Jinan University,
   Key-Area Research and Development Program of Guangdong Province (No.
   2020B1111100001) and Guangzhou Key Laboratory of Formula-Pattern of
   Traditional Chinese Medicine, China.
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NR 47
TC 5
Z9 5
U1 3
U2 37
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2095-4964
J9 J INTEGR MED-JIM
JI J. Integr. Med.-JIM
PD SEP
PY 2022
VL 20
IS 5
BP 442
EP 452
DI 10.1016/j.joim.2022.07.003
EA AUG 2022
PG 11
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA 4X3AO
UT WOS:000860718900008
PM 35906133
OA hybrid
DA 2025-06-11
ER

PT J
AU Shrout, MR
   Wilson, SJ
   Farrell, AK
   Rice, TM
   Weiser, DA
   Novak, JR
   Monk, JK
AF Shrout, M. Rosie
   Wilson, Stephanie J.
   Farrell, Allison K.
   Rice, TeKisha M.
   Weiser, Dana A.
   Novak, Joshua R.
   Monk, J. Kale
TI Dyadic, biobehavioral, and sociocultural approaches to romantic
   relationships and health: Implications for research, practice, and
   policy
SO SOCIAL AND PERSONALITY PSYCHOLOGY COMPASS
LA English
DT Review
DE couples; convergence; health; intersectionality; marriage;
   psychoneuroimmunology; romantic relationships; stress reactivity
ID MARITAL SATISFACTION; PSYCHOLOGICAL DISTRESS; PHYSIOLOGICAL LINKAGE;
   SPOUSAL CONCORDANCE; DEPRESSIVE SYMPTOMS; METABOLIC SYNDROME; LEGAL
   RECOGNITION; MENTAL-HEALTH; COUPLES; STRESS
AB Romantic relationships are a key health determinant. Partners influence each other's psychological, behavioral, and biological trajectories in ways that can foster health and longevity or fuel disease risk and early mortality. A romantic relationship's health impact is considerable yet has historically garnered limited recognition from government agencies, healthcare providers, and policymakers. World-wide public health organizations are increasingly attending to the importance of social connection and health and calling for action and intervention to improve social connection. In this review, we identify key areas to act on this call and advance research, practice, and policy on romantic relationships and health: dyadic effects in how partners influence each other's health; the socio-historical context and systems of social stratification; and couple-level prevention, intervention, and health-promotion efforts. We connect these perspectives and offer next steps to further establish romantic relationships as a public health priority and target for policy and programming that foster social connection and health.
C1 [Shrout, M. Rosie] Purdue Univ, Human Dev & Family Sci, W Lafayette, IN 47907 USA.
   [Shrout, M. Rosie] Purdue Univ, Ctr Aging & Life Course, W Lafayette, IN USA.
   [Wilson, Stephanie J.] Southern Methodist Univ, Psychol, Dallas, TX USA.
   [Farrell, Allison K.] Miami Univ, Psychol, Oxford, OH USA.
   [Rice, TeKisha M.] Virginia Tech Univ, Human Dev & Family Sci, Blacksburg, VT USA.
   [Weiser, Dana A.] Texas Tech Univ, Human Dev & Family Sci, Lubbock, TX USA.
   [Novak, Joshua R.] Auburn Univ, Human Dev & Family Sci, Auburn, AL USA.
   [Monk, J. Kale] Univ Missouri, Human Dev & Family Sci, Columbia, MO USA.
C3 Purdue University System; Purdue University; Purdue University System;
   Purdue University; Southern Methodist University; University System of
   Ohio; Miami University; Texas Tech University System; Texas Tech
   University; Auburn University System; Auburn University; University of
   Missouri System; University of Missouri Columbia
RP Shrout, MR (corresponding author), Purdue Univ, Human Dev & Family Sci, W Lafayette, IN 47907 USA.
EM Shrout@purdue.edu
RI Rice, TeKisha/AAB-2648-2020; Monk, Kale/AAH-2420-2021
OI Rice Wallace, TeKisha/0000-0003-1732-5322; Novak,
   Joshua/0000-0002-9714-1226; Monk, J. Kale/0000-0002-5739-5635; Shrout,
   M. Rosie/0000-0001-5751-1782; Weiser, Dana/0000-0001-7478-4811; Farrell,
   Allison/0000-0002-8233-4076
FU National Center for Advancing Translational Sciences [KL2TR002530,
   K12TR004415, R00 AG056667]; NIH; Alabama Agricultural Experiment Station
   of the National Institute of Food and Agriculture, U.S. Department of
   Agriculture
FX No acknowledgements. Work on this project was supported by NIH grants
   KL2TR002530, K12TR004415, R00 AG056667, and the Alabama Agricultural
   Experiment Station of the National Institute of Food and Agriculture,
   U.S. Department of Agriculture.
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NR 154
TC 5
Z9 6
U1 3
U2 12
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
EI 1751-9004
J9 SOC PERSONAL PSYCHOL
JI Soc. Personal. Psychol. Compass
PD FEB
PY 2024
VL 18
IS 2
AR e12943
DI 10.1111/spc3.12943
PG 19
WC Psychology, Social
WE Social Science Citation Index (SSCI)
SC Psychology
GA HL6U3
UT WOS:001159707700001
DA 2025-06-11
ER

PT J
AU McPherson, RJ
   Mascher-Denen, M
   Juul, SE
AF McPherson, Ronald J.
   Mascher-Denen, Marcella
   Juul, Sandra E.
TI Postnatal Stress Produces Hyperglycemia in Adult Rats Exposed to
   Hypoxia-Ischemia
SO PEDIATRIC RESEARCH
LA English
DT Article
ID PITUITARY-ADRENAL AXIS; PRETERM INFANTS; GLUCOCORTICOID EXPOSURE;
   MATERNAL-DEPRIVATION; BLOOD-PRESSURE; GROWTH; BIRTH; NEWBORN; WEIGHT;
   LEADS
AB Fetal or early postnatal stressors may predispose infants to develop diabetes, metabolic syndrome, or stroke. We hypothesized that postnatal stress will predispose animals to develop metabolic syndrome and impair the physiologic response to hypoxic-ischemic brain injury. We characterized the short- and long-term physiologic responses to postnatal stress by examining corticosterone (CS), glucose metabolism, and brain injury in neonatal and adult rats exposed to hypoxia-ischemia (H-I). Rat pups were divided into three levels of postnatal stress from postnatal day (P) 3 to P7. All rats underwent unilateral brain injury on either P7 or P134. We measured brain injury, growth, blood pressure, urine/plasma CS, plasma leptin, insulin, and glucose before and after H-I. Postnatal stress increased neonatal CS production, exacerbated neonatal white matter injury, and was associated with adult hyperglycemia after H-I despite increased insulin production. There were no group differences in adult weight, blood pressure, or leptin. Postnatal stress exacerbated brain injury and produced adult hyperglycemia, triggered after hypoxia exposure, consistent with the hypotheses that neonates exposed to early stress are more vulnerable to hypoxia and may be predisposed to develop metabolic syndrome in adulthood. Prolonged maternal separation produced more hyperglycemia than did brief daily handling. (Pediatr Res 66: 278-282, 2009)
C1 [Juul, Sandra E.] Univ Washington, Dept Pediat, Div Neonatol, Seattle, WA 98195 USA.
   [Mascher-Denen, Marcella] Driscoll Childrens Hosp, Neonatol Unit, Corpus Christi, TX 78411 USA.
C3 University of Washington; University of Washington Seattle
RP Juul, SE (corresponding author), Univ Washington, Dept Pediat, Div Neonatol, Box 356320, Seattle, WA 98195 USA.
EM sjuul@u.washington.edu
RI Ledbetter, Sandra/IYJ-9748-2023
FU WO Therapeutics; Neonatal Biology Research Fund
FX Supported by WO Therapeutics and the Neonatal Biology Research Fund.
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NR 50
TC 28
Z9 30
U1 0
U2 1
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0031-3998
EI 1530-0447
J9 PEDIATR RES
JI Pediatr. Res.
PD SEP
PY 2009
VL 66
IS 3
BP 278
EP 282
DI 10.1203/PDR.0b013e3181b1bd1b
PG 5
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA 488HK
UT WOS:000269339800007
PM 19531978
OA Bronze
DA 2025-06-11
ER

PT J
AU Johnson, AH
   Phillips, SR
   Rice, M
AF Johnson, Ann H.
   Rodgers Phillips, Shameka
   Rice, Marti
TI Abnormal weight gain with fatigue and stress in early survivorship after
   childhood brain tumor diagnosis
SO JOURNAL FOR SPECIALISTS IN PEDIATRIC NURSING
LA English
DT Article
DE adiposity; BMI; childhood brain tumor; fatigue; survivorship
ID BODY-MASS-INDEX; LONG-TERM SURVIVORS; ACUTE LYMPHOBLASTIC-LEUKEMIA;
   TO-HIP RATIO; HYPOTHALAMIC OBESITY; METABOLIC SYNDROME; ADULT SURVIVORS;
   RISK-FACTORS; ENERGY-EXPENDITURE; PEDIATRIC CANCER
AB Background Diagnosis and treatment for individuals with brain tumors during childhood involves sequelae, including abnormal weight gain. This symptom is commonly clustered with fatigue and increased risk for cardiovascular disease. Children's Oncology Group recommendations include annual surveillance of body mass index (BMI) and cardiometabolic comorbidities; however, there has been little emphasis on individualized screening early in survivorship.
   Purpose The primary purpose of this paper is to describe the findings of abnormal weight gain and its correlates in a sample of young childhood brain tumor survivors during early survivorship.
   Design and Methods This cross-sectional multi-site study included brain tumor survivors of ages 8-12 years who were less than 6 years posttreatment. Convenience sampling from two pediatric cancer centers in the southern United States was utilized. Data collected included BMI, parent report of sleep, and child report of fatigue and stress.
   Results The sample (N = 21) consisted of children who had received chemotherapy, radiation treatment, and surgery for childhood brain tumor. BMI in overweight and obese categories exceeded normative samples with 38% at or above the 85th percentile. There were clinically significant relationships with fatigue, stress about weight, tumor location, cranial radiation, chemotherapy, and recurrence
   Practice Implications Screening for abnormal weight gain and related factors, such as fatigue should begin early in survivorship after childhood brain tumor treatment completion with the aim of health promotion and disease prevention. Adiposity measurement techniques should be utilized in future clinical and research settings to improve assessment of cardiometabolic risk.
C1 [Johnson, Ann H.] Texas Christian Univ, Harris Coll Nursing & Hlth Sci, TCU Box 298620, Ft Worth, TX 76129 USA.
   [Rodgers Phillips, Shameka; Rice, Marti] Univ Alabama Birmingham, Sch Nursing, Birmingham, AL USA.
C3 Texas Christian University; University of Alabama System; University of
   Alabama Birmingham
RP Johnson, AH (corresponding author), Texas Christian Univ, Harris Coll Nursing & Hlth Sci, TCU Box 298620, Ft Worth, TX 76129 USA.
EM ann.h.johnson@tcu.edu
OI Phillips, Shameka/0000-0002-3412-1623; Johnson, Ann/0000-0003-4647-145X
FU Society of Pediatric Nurses; Maternal Child Health Bureau [T80MC09653];
   National Heart, Lung, and Blood Institute [T32HL105349]; American Heart
   Association [17SFRN336101011]
FX Society of Pediatric Nurses, Grant/Award Number: Corrine Barnes Grant;
   Maternal Child Health Bureau, Grant/Award Number: T80MC09653; National
   Heart, Lung, and Blood Institute, Grant/Award Number: T32HL105349;
   American Heart Association, Grant/Award Number: 17SFRN336101011
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NR 67
TC 3
Z9 3
U1 0
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1539-0136
EI 1744-6155
J9 J SPEC PEDIATR NURS
JI J. Spec. Pediatr. Nurs.
PD JUL
PY 2020
VL 25
IS 3
AR e12288
DI 10.1111/jspn.12288
EA FEB 2020
PG 8
WC Nursing; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Pediatrics
GA MM4VB
UT WOS:000513726400001
PM 32065725
DA 2025-06-11
ER

PT J
AU Hoffman, GJ
   Lee, J
   Mendez-Luck, CA
AF Hoffman, Geoffrey J.
   Lee, Jihey
   Mendez-Luck, Carolyn A.
TI Health Behaviors Among Baby Boomer Informal Caregivers
SO GERONTOLOGIST
LA English
DT Article
DE Caregiving-Informal; Behavior; Caregiver stress; Stress and coping;
   Nutrition; Exercise
ID MENTAL-HEALTH; METABOLIC SYNDROME; PHYSICAL HEALTH; ADULT CHILDREN; US
   ADULTS; SELF-CARE; STRESS; OBESITY; ASSOCIATIONS; CONSUMPTION
AB Purpose of the Study: This study examines health-risk behaviors among "Baby Boomer" caregivers and non-caregivers. Design and Methods: Data from the 2009 California Health Interview Survey of the state's non-institutionalized population provided individual-level, caregiving, and health behavior characteristics for 5,688 informal caregivers and 12,941 non-caregivers. Logistic regression models were estimated separately for four individual health-risk behaviors-smoking, sedentary behavior, and regular soda and fast-food consumption-as well as a global health-risk measure. Results: Controlling for psychological distress and personal characteristics and social resources such as age, gender, income and education, work and marital status, and neighborhood safety, caregivers had greater odds than non-caregivers of overall negative health behavior and of smoking and regular soda and fast-food consumption. We did not observe significant differences in odds of negative behavior related to stress for spousal caregivers and caregivers in the role for longer periods of time or those providing more hours of weekly care compared with other caregivers. Implications: Our study found evidence that Baby Boomer caregivers engage in poor health behaviors that are associated with exposure to caregiving. Baby Boomer caregivers may be at risk for certain behavioral factors that are associated with disability and chronic illness.
C1 [Hoffman, Geoffrey J.] Univ Calif Los Angeles, Sch Publ Hlth, Dept Hlth Serv, Los Angeles, CA 90095 USA.
   [Lee, Jihey] Univ Calif Los Angeles, Sch Publ Hlth, Dept Biostat, Los Angeles, CA 90095 USA.
   [Mendez-Luck, Carolyn A.] Oregon State Univ, Coll Publ Hlth & Human Sci, Sch Social & Behav Sci, Corvallis, OR 97331 USA.
C3 University of California System; University of California Los Angeles;
   University of California System; University of California Los Angeles;
   Oregon State University
RP Hoffman, GJ (corresponding author), Univ Calif Los Angeles, Sch Publ Hlth, Dept Hlth Serv, 650 Charles Young Dr S,31-269 CHS,Box 951772, Los Angeles, CA 90095 USA.
EM gjh@ucla.edu
OI Hoffman, Geoffrey/0000-0002-3583-6532
FU AHRQ HHS [T32 HS 46-20] Funding Source: Medline; NIA NIH HHS
   [1K01AG033122-01A1, K01 AG033122] Funding Source: Medline
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NR 61
TC 78
Z9 100
U1 1
U2 30
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0016-9013
EI 1758-5341
J9 GERONTOLOGIST
JI Gerontologist
PD APR
PY 2012
VL 52
IS 2
SI SI
BP 219
EP 230
DI 10.1093/geront/gns003
PG 12
WC Gerontology
WE Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA 913SD
UT WOS:000301896800008
PM 22391873
OA Green Published
DA 2025-06-11
ER

PT J
AU Czepczynski, R
   Smolarek, I
   Rogacka, D
   Kazmierczak, M
   Wysocki, H
   Sowinski, J
AF Czepczynski, R.
   Smolarek, I.
   Rogacka, D.
   Kazmierczak, M.
   Wysocki, H.
   Sowinski, J.
TI Myocardial perfusion SPECT with dipyridamole stress test in cardiac
   syndrome X
SO NUKLEARMEDIZIN-NUCLEAR MEDICINE
LA English
DT Article
DE cardiac syndrome X; Tc-99m-sestamibi; SPECT; dipyridamole; coronary
   angiography
ID NORMAL CORONARY ANGIOGRAMS; EMISSION COMPUTED-TOMOGRAPHY;
   ANGINA-PECTORIS; ARTERY DISEASE; EXERCISE; ECHOCARDIOGRAPHY;
   ARTERIOGRAMS; DYSFUNCTION; RESERVE; WOMEN
AB Cardiac syndrome X defines patients with typical anginal chest pain, a positive exercise ECG stress test and angiographically normal coronary arteries. Aim of this study was to evaluate the role of myocardial perfusion SPECF with dipyridamole stress in the diagnosis of cardiac syndrome X. Patients, methods: 68 patients with syndrome X aged 32 to 60 years were subjected to myocardial imaging using Tc-99m-MIBI according to the two-cloys protocol: at rest and after dipyridomole infusion. Semiquantitative evaluation of the images was based on the assessment of Tc-99m-MIBI uptake in 17 myocardial segments using a 5-points scale (0 point-normal uptake, 4 points-no uptake). Scores obtained in each segment were summed up, constituting the summed rest score (SRS) and summed stress score (SSS). Results: Mean SRS was 7.9 +/- 4.8 and mean SSS was 7.2 +/- 4.4 (non-significant difference). Individual comparison of SRS and SSS values revealed three patterns of scintigraphic images: 1) in 25 patients (36.8%), a paradoxical improvement of perfusion at stress images was found, 2) in 23 patients (33.8%), the myocardial perfusion deteriorated after dipyridamole, 3) in 20 patients (29.4%), no significant change of the myocardial perfusion between rest and stress images occurred. Conclusions: In cardiac syndrome X, myocardial SPECT with dipyridamole stress shows different patterns of myocardial perfusion that reflects heterogeneity of this pathology.
C1 Poznan Univ Med Sci, Nucl Med Unit, PL-60355 Poznan, Poland.
   Poznan Univ Med Sci, Dept Endocrinol & Metab, PL-60355 Poznan, Poland.
   Poznan Univ Med Sci, Dept Intens Care & Cardiol, PL-60355 Poznan, Poland.
C3 Poznan University of Medical Sciences; Poznan University of Medical
   Sciences; Poznan University of Medical Sciences
RP Czepczynski, R (corresponding author), Poznan Univ Med Sci, Nucl Med Unit, Przybyszewskiego 49, PL-60355 Poznan, Poland.
EM tarmed@poczta.onet.pl
OI Smolarek, Iwona/0000-0001-6694-9989
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NR 29
TC 3
Z9 5
U1 0
U2 1
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0029-5566
J9 NUKLEARMED-NUCL MED
JI Nuklearmedizin
PY 2006
VL 45
IS 3
BP 111
EP 114
PG 4
WC Radiology, Nuclear Medicine & Medical Imaging
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Radiology, Nuclear Medicine & Medical Imaging
GA 047HO
UT WOS:000237870600005
PM 16710506
DA 2025-06-11
ER

PT J
AU Lai, QC
   Ye, L
   Luo, J
   Zhang, C
   Wu, QC
   Shao, Y
AF Lai, Qiancheng
   Ye, Liu
   Luo, Jun
   Zhang, Cheng
   Wu, Qingchen
   Shao, Yue
TI The cross-sectional correlation between the oxidative balance score and
   cardiometabolic risk factors and its potential correlation with
   longitudinal mortality in patients with cardiometabolic risk factors
SO BMC PUBLIC HEALTH
LA English
DT Article
DE Cardiometabolic risk factors; Mortality; NHANES; Oxidative balance score
ID LIPID-PEROXIDATION; NITRIC-OXIDE; STRESS; MARKERS; INFLAMMATION; DISEASE
AB Background This study analyzes the correlation between oxidative balance score (OBS), cardiometabolic risk factors (CMRFs), and mortality in individuals with CMRFs.Methods Data were chosen from the National Health and Nutrition Examination Survey. The survey-weighted multivariable logistic regression models were implemented to explore the relationship between OBS and the risk of CMRFs. Then, Cox proportional hazard models were employed to estimate the impact of OBS on mortality in individuals with CMRFs.Results Following multivariate adjustment, the subjects in the highest quartile exhibited a 46% reduction in the risk of CMRFs, a 33% reduction in the risk of diabetes, a 31% reduction in the risk of hypertension, and a 36% reduction in the risk of hyperlipidemia, compared with those in the lowest quartile. Furthermore, each 1-unit increase in OBS was remarkably negatively correlated with the prevalence of CMRFs, diabetes, hypertension, and hyperlipidemia. The correlation between OBS and CMFRs was found to be mediated by serum gamma-glutamyltransferase (GGT) and white blood cells (WBC), and the mediation effect of GGT levels and WBC, accounting for 6.90% and 11.51%, respectively. Lastly, the multivariate Cox regression model revealed that elevated OBS, irrespective of whether it was treated as a categorical or continuous variable, exhibited a significant association with decreased mortality from all causes, cardiovascular disease, and cancer.Conclusions An increased OBS might reflect a lower risk of CMRFs and a favorable prognosis for individuals with CMRFs. Moreover, WBC and GGT may play a potential mediating role between OBS and CMRFs.
C1 [Lai, Qiancheng] Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Dept Cardiac Surg, Chengdu, Peoples R China.
   [Ye, Liu] Chongqing Med Univ, Affiliated Hosp 1, Hlth Management Ctr, Branch 1, Chongqing, Peoples R China.
   [Luo, Jun; Zhang, Cheng; Wu, Qingchen; Shao, Yue] Chongqing Med Univ, Affiliated Hosp 1, Dept Cardiothorac Surg, 1 Youyi Rd, Chongqing, Peoples R China.
C3 Sichuan Provincial People's Hospital; University of Electronic Science &
   Technology of China; Chongqing Medical University; Chongqing Medical
   University
RP Shao, Y (corresponding author), Chongqing Med Univ, Affiliated Hosp 1, Dept Cardiothorac Surg, 1 Youyi Rd, Chongqing, Peoples R China.
EM shaoyuecq@163.com
FU Chengdu Science and Technology Bureau
FX None.
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NR 45
TC 4
Z9 4
U1 1
U2 6
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2458
J9 BMC PUBLIC HEALTH
JI BMC Public Health
PD MAY 30
PY 2024
VL 24
IS 1
AR 1452
DI 10.1186/s12889-024-18967-z
PG 10
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA SR4T7
UT WOS:001236172000007
PM 38816823
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Celenay, ST
   Kaya, DO
   Sas, S
AF Celenay, Seyda Toprak
   Kaya, Derya Ozer
   Sas, Senem
TI Does the Presence of Metabolic Syndrome Alter Serum Uric Acid
   Concentrations, Pain, and Well-Being in Patient with Chronic
   Musculoskeletal Pain
SO CLINICAL AND EXPERIMENTAL HEALTH SCIENCES
LA English
DT Article
DE Metabolic syndrome; pain; uric acid; body composition; quality of life
ID QUALITY-OF-LIFE; DEPRESSIVE SYMPTOMS; PHYSICAL-ACTIVITY; ASSOCIATION;
   HEALTH; RISK; ANXIETY; WOMEN; PANEL
AB Objective: To compare serum uric acid concentrations, pain and well-being in patients having chronic musculoskeletal pain with and without MetS, and investigate cut-off values.
   Methods: Patients having chronic musculoskeletal pain with (MetS group, n=48) and without MetS (control group, n=52) were included. The serum uric acid concentration, pain intensity, body composition, physical activity level, quality of life, and psychological status were evaluated by a uric acid blood test, Visual Analogue Scale, Bio-impedance Analyzer, International Physical Activity Questionnaire-7 (IPAQ-7), Nottingham Health Profile, and Hospital Anxiety and Depression Scale, respectively.
   Results: Uric acid level, fat mass, waist/hip ratio were found higher in the MetS group in comparison to the control group (P<0.05). It was seen that patients in the MetS group had lower physical activity levels than those in the control group (P<0.05). The cut-off points of the uric acid level, fat mass, waist/hip ratio, and physical activity level for detecting MetS were found as 5.25 mg/dl, 37.50 kg, 0.91, and 247.25 METsminutes/week, respectively.
   Conclusion: Patients with MetS had a greater uric acid level, fat mass, waist/hip ratio, and a lower physical activity level than those without MetS. The increase of uric acid level, fat mass, and waist/hip ratio, and the decrease of physical activity may be critical for patients having musculoskeletal pain with MetS. These results should be considered for the management of these patients.
C1 [Celenay, Seyda Toprak] Ankara Yildirim Beyazit Univ, Hlth Sci Fac, Dept Physiotherapy & Rehabil, Ankara, Turkey.
   [Kaya, Derya Ozer] Izmir Katip Celebi Univ, Hlth Sci Fac, Dept Physiotherapy & Rehabil, Izmir, Turkey.
   [Sas, Senem] Erciyes Univ, Med Fac, Div Rheumatol, Dept Phys Med & Rehabil, Kayseri, Turkey.
C3 Ankara Yildirim Beyazit University; Izmir Katip Celebi University;
   Erciyes University
RP Celenay, ST (corresponding author), Ankara Yildirim Beyazit Univ, Hlth Sci Fac, Dept Physiotherapy & Rehabil, Ankara, Turkey.
EM sydtoprak@hotmail.com
RI Şaş, Senem/C-2521-2018; Ozer Kaya, Derya/AFH-7699-2022; Celenay,
   Seyda/AAM-4376-2021
OI Sas, Senem/0000-0002-5616-5723; Ozer Kaya, Derya/0000-0002-6899-852X
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NR 30
TC 0
Z9 0
U1 3
U2 4
PU MARMARA UNIV, INST HEALTH SCIENCES
PI ISTANBUL
PA MARMARA U BASIBUYUK SAGLIK YERLESKESI, SAGLIK BILIMLERI ENSTITUSU
   MUDURLUGU, BASIBUYUK YOLU 9-3, ISTANBUL, 34854, TURKEY
SN 2459-1459
J9 CLIN EXP HEALTH SCI
JI Clin. Exp. Health Sci.
PD DEC
PY 2022
VL 12
IS 4
BP 793
EP 798
DI 10.33808/clinexphealthsci.832112
PG 6
WC Medicine, Research & Experimental
WE Emerging Sources Citation Index (ESCI)
SC Research & Experimental Medicine
GA D9YD5
UT WOS:000972204100002
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Komulainen, P
   Lakka, TA
   Kivipelto, M
   Hassinen, M
   Helkala, EL
   Haapala, I
   Nissinen, A
   Rauramaa, R
AF Komulainen, Pirjo
   Lakka, Timo A.
   Kivipelto, Miia
   Hassinen, Maija
   Helkala, Eeva-Liisa
   Haapala, Irja
   Nissinen, Aulikki
   Rauramaa, Rainer
TI Metabolic syndrome and cognitive function: A population-based follow-up
   study in elderly women
SO DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
LA English
DT Article
DE cognitive function; metabolic syndrome; elderly women
ID ALZHEIMERS-DISEASE; BLOOD-PRESSURE; RISK-FACTORS; DEMENTIA;
   INFLAMMATION; DECLINE; INSULIN; MEMORY
AB Objective: To test the hypothesis that metabolic syndrome predicts cognitive impairment, and to examine the association of single metabolic risk factors with cognitive functioning. Methods: We performed a 12-year follow-up study in a population-based sample of 101 women aged 60 - 70 years at baseline. Metabolic syndrome was defined by the National Cholesterol Education Program criteria (>= 3 out of 5 risk factors). Global cognitive function was measured by the Mini-Mental State Examination both at baseline and follow-up. A detailed neuropsychological evaluation for memory and cognitive speed was performed at follow-up. Results: The prevalence of metabolic syndrome increased from 13% at baseline to 49% at follow-up ( p < 0.001). Women with metabolic syndrome at baseline had a 4.27 (95% confidence interval: 1.02 - 17.90; p = 0.047) times higher risk of poor memory at follow-up after adjustment for age, education and depression. The increasing number of metabolic risk factors was associated with worsening of memory at follow-up ( p = 0.034 for linear trend). Women with low baseline levels of high-density lipoprotein (HDL) cholesterol were more likely to have poor memory at follow-up than those with higher HDL levels ( p = 0.028). The risk of having poor memory increased by 46.5% (95% confidence interval: 15 - 66%; p = 0.008) with 1 SD decrease in HDL cholesterol level. Conclusion: In elderly women, metabolic syndrome may be an important contributor to worsening of memory, which is an essential part of mild cognitive impairment. Copyright (C) 2007 S. Karger AG, Basel.
C1 Univ Kuopio, Kuopio Res Inst Exercise Med, FI-70100 Kuopio, Finland.
   Univ Kuopio, Dept Physiol, Inst Biomed, FI-70100 Kuopio, Finland.
   Univ Kuopio, Dept Neurol & Neurosci, FI-70100 Kuopio, Finland.
   Univ Kuopio, Dept Publ Hlth & Gen Practice, FI-70100 Kuopio, Finland.
   Kuopio Univ Hosp, Dept Clin Physiol & Nucl Med, SF-70210 Kuopio, Finland.
   Natl Publ Hlth Inst, Dept Epidemiol & Hlth Promot, Helsinki, Finland.
   Karolinska Inst, Aging Res Ctr, Stockholm, Sweden.
   Kings Coll London, Dept Nutr & Dietet, London WC2R 2LS, England.
C3 University of Eastern Finland; University of Eastern Finland; University
   of Eastern Finland; University of Eastern Finland; Kuopio University
   Hospital; University of Eastern Finland; University of Eastern Finland
   Hospital; Finland National Institute for Health & Welfare; Karolinska
   Institutet; University of London; King's College London
RP Komulainen, P (corresponding author), Univ Kuopio, Kuopio Res Inst Exercise Med, Haapaniementie 16, FI-70100 Kuopio, Finland.
EM Pirjo.Komulainen@uku.fi
RI Kivipelto, Miia/AAS-3557-2021; Komulainen, Pirjo/MVY-1409-2025
OI Lakka, Timo/0000-0002-9199-2871; HAAPALA-BIGGS,
   IRJA/0000-0001-5624-3018; Kivipelto, Miia/0000-0003-0992-3875
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NR 30
TC 124
Z9 134
U1 0
U2 4
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1420-8008
EI 1421-9824
J9 DEMENT GERIATR COGN
JI Dement. Geriatr. Cogn. Disord.
PY 2007
VL 23
IS 1
BP 29
EP 34
DI 10.1159/000096636
PG 6
WC Geriatrics & Gerontology; Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology; Neurosciences & Neurology; Psychiatry
GA 107JT
UT WOS:000242167700004
PM 17068394
DA 2025-06-11
ER

PT J
AU Jose, N
   Vasant, PK
   Kulirankal, KG
AF Jose, Nijin
   Vasant, P. K.
   Kulirankal, Kiran G.
TI Study of Endothelial Dysfunction in Patients With Non-alcoholic Fatty
   Liver Disease
SO CUREUS JOURNAL OF MEDICAL SCIENCE
LA English
DT Article
DE flow-mediated vasodilation; bmi; non-alcoholic fatty liver disease;
   endothelial dysfunction; metabolic syndrome
ID C-REACTIVE PROTEIN; METABOLIC SYNDROME; PREVALENCE; RISK; POPULATION;
   OBESITY
AB Background
   Metabolic syndrome (syndrome X) is the name for a group of risk factors that raises your risk for heart disease and other health problems, such as diabetes and stroke. Dilatation of blood vessels following stress is a function of vasodilators produced by the endothelium. Flow-mediated vasodilation assesses endothelial function. In the case of endothelial dysfunction, flow-mediated vasodilation is impaired, resulting in decreased or even absence of vasodilation following stress. The easy availability of ultrasound machines nowadays and the non-invasive nature of the test make this a practical test for assessing endothelial dysfunction and the risk of cardiovascular diseases. Various studies have confirmed the presence of impaired flow-mediated vasodilation in patients with coronary artery disease. However, the presence of impaired flow-mediated vasodilation in individuals with risk factors but no cardiovascular diseases can prove that this can be used to predict individuals at risk. This study tries to confirm the presence of endothelial dysfunction in patients with non-alcoholic fatty liver disease (NAFLD) attending a tertiary center hospital in Kochi.
   Objectives
   The study's main aim is to compare flow-mediated dilatation in patients with NAFLD and normal individuals. Materials and methods The comparative study was conducted among 50 patients attending various outpatient departments in Amrita Institute of Medical Sciences, Kochi. History and examination of cases and controls and relevant investigations were done after obtaining consent. In addition, both groups underwent measurement of flow-mediated vasodilation in the radiology department. Data were entered in Microsoft Excel and were analyzed using SPSS.
   Results
   Flow-mediated vasodilation was found to be less in patients with fatty liver (7.37 +/- 2.75) when compared to individuals with normal liver (12.41 +/- 3.71). In addition, flow-mediated vasodilatation was inversely proportional to BMI and age.
   Conclusion
   This study has proved that there will be endothelial dysfunction in NAFLD, as shown by the decrease in flow-mediated vasodilation when compared with normal liver.
C1 [Jose, Nijin] Jubilee Mission Med Coll & Res Inst, Internal Med, Trichur, India.
   [Vasant, P. K.; Kulirankal, Kiran G.] Amrita Inst Med Sci, Internal Med, Kochi, Kerala, India.
C3 Amrita Vishwa Vidyapeetham; Amrita Vishwa Vidyapeetham Kochi
RP Kulirankal, KG (corresponding author), Amrita Inst Med Sci, Internal Med, Kochi, Kerala, India.
EM kirangkulirankal@gmail.com
OI kulirankal, kiran/0000-0003-3154-2462
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   Park YW, 2003, ARCH INTERN MED, V163, P427, DOI 10.1001/archinte.163.4.427
   Pradhan AD, 2001, JAMA-J AM MED ASSOC, V286, P327, DOI 10.1001/jama.286.3.327
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   Shukla Vaibhav, 2017, J Assoc Physicians India, V65, P18
NR 15
TC 6
Z9 6
U1 0
U2 2
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
EI 2168-8184
J9 CUREUS J MED SCIENCE
JI Cureus J Med Sci
PD DEC 19
PY 2021
VL 13
IS 12
AR e20515
DI 10.7759/cureus.20515
PG 6
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA XU3XD
UT WOS:000734201200015
PM 34950560
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Baek, JH
   Han, K
   Kim, H
   Yang, K
   Jeon, HJ
AF Baek, Ji Hyun
   Han, Kyungdo
   Kim, Hyewon
   Yang, Kyojin
   Jeon, Hong Jin
TI Increased metabolic variability in Korean patients with new onset
   bipolar disorder: a nationwide cohort study
SO FRONTIERS IN PSYCHIATRY
LA English
DT Article
DE bipolar disorder; metabolic variability; metabolic syndrome; old age
   onset bipolar disorder; modifiable risk factor
ID BLOOD-PRESSURE; CHOLESTEROL VARIABILITY; MOOD DISORDERS; RISK;
   DEPRESSION; MORTALITY; OUTCOMES; DISEASE; OBESITY; STROKE
AB Introduction The aim of this study was to determine associations between changes of metabolic parameters and the development of BD using nationally representative data. Methods We used health examination data provided by the South Korean National Health Insurance System (NHIS) (n = 8,326,953). The variability of each metabolic parameter including weight circumference, blood pressure, fasting blood glucose, high-density lipoprotein cholesterol, and triglyceride levels was caculated using variability independent of mean (VIM) indices. The presence of metabolic syndrome was associated with new onset BD. Each metabolic parameter with high variability was associated with a higher risk of new onset BD compared to those with low variability after adjusting for age, sex, smoking, alcohol drinking, regular exercise, income status, baseline diabetes, hypertension, and dyslipidemia. Results As the number of highly variable metabolic parameters increased, the risk for new onset depression also increased even after covariates adjustment. The associations between new onset BD and metabolic variability were greater in populations with age > 50 years. In addition, these associations remained significant after adjusting for the presence of depression prior to diagnoses of BD. Discussion Our results suggest possibility of metabolic variability as an independent environmental risk factor for BD even after adjusting for the presence of metabolic syndrome.
C1 [Baek, Ji Hyun; Kim, Hyewon; Yang, Kyojin; Jeon, Hong Jin] Sungkyunkwan Univ, Depress Ctr, Samsung Med Ctr, Dept Psychiat,Sch Med, Seoul, South Korea.
   [Baek, Ji Hyun] Massachusetts Gen Hosp, Dauten Family Ctr Bipolar Treatment Innovat, Boston, MA USA.
   [Han, Kyungdo] Soongsil Univ, Dept Stat & Actuarial Sci, Seoul, South Korea.
   [Jeon, Hong Jin] Sungkyunkwan Univ, Samsung Adv Inst Hlth Sci & Technol SAIHST, Dept Hlth Sci & Technol, Dept Med Device Management & Res, Seoul, South Korea.
   [Jeon, Hong Jin] Sungkyunkwan Univ, Samsung Adv Inst Hlth Sci & Technol SAIHST, Dept Clin Res Design & Evaluat, Seoul, South Korea.
C3 Sungkyunkwan University (SKKU); Samsung Medical Center; Harvard
   University; Harvard University Medical Affiliates; Massachusetts General
   Hospital; Soongsil University; Sungkyunkwan University (SKKU); Samsung;
   Sungkyunkwan University (SKKU); Samsung
RP Jeon, HJ (corresponding author), Sungkyunkwan Univ, Depress Ctr, Samsung Med Ctr, Dept Psychiat,Sch Med, Seoul, South Korea.; Jeon, HJ (corresponding author), Sungkyunkwan Univ, Samsung Adv Inst Hlth Sci & Technol SAIHST, Dept Hlth Sci & Technol, Dept Med Device Management & Res, Seoul, South Korea.; Jeon, HJ (corresponding author), Sungkyunkwan Univ, Samsung Adv Inst Hlth Sci & Technol SAIHST, Dept Clin Res Design & Evaluat, Seoul, South Korea.
EM jeonhj@skku.edu
RI Baek, Ji Hyun/JJF-8250-2023
FU Ministry of Trade, Industry & Energy (MOTIE, Korea) [20014967]; Korea
   Health Technology R&D Project through the Korea Health Industry
   Development Institute (KHIDI) - Ministry of Health & Welfare, Republic
   of Korea [HR21C0885]
FX The author(s) declare financial support was received for the research,
   authorship, and/or publication of this article. This work was supported
   by the Technology Innovation Program (or Industrial Strategic Technology
   Development Program-Source Technology Development and Commercialization
   of Digital Therapeutics) (20014967, Development of Digital Therapeutics
   for Depression from COVID19) funded by the Ministry of Trade, Industry &
   Energy (MOTIE, Korea). It was also supported by a grant (HR21C0885) of
   the Korea Health Technology R&D Project through the Korea Health
   Industry Development Institute (KHIDI) funded by the Ministry of Health
   & Welfare, Republic of Korea.
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NR 38
TC 0
Z9 0
U1 0
U2 0
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-0640
J9 FRONT PSYCHIATRY
JI Front. Psychiatry
PD JAN 8
PY 2024
VL 14
AR 1256458
DI 10.3389/fpsyt.2023.1256458
PG 9
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA GS8B4
UT WOS:001154742000001
PM 38260805
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Assoumou, HGN
   Pichot, V
   Barthelemy, JC
   Dauphinot, V
   Celle, S
   Gosse, P
   Kossovsky, M
   Gaspoz, JM
   Roche, F
AF Assoumou, H. G. Ntougou
   Pichot, V.
   Barthelemy, J. C.
   Dauphinot, V.
   Celle, S.
   Gosse, P.
   Kossovsky, M.
   Gaspoz, J. M.
   Roche, F.
TI Metabolic Syndrome and Short-Term and Long-Term Heart Rate Variability
   in Elderly Free of Clinical Cardiovascular Disease: The PROOF Study
SO REJUVENATION RESEARCH
LA English
DT Article
ID DENSITY-LIPOPROTEIN CHOLESTEROL; INSULIN-RESISTANCE; AUTONOMIC FUNCTION;
   RISK; MORTALITY; HYPERTENSION; ASSOCIATIONS; STIMULATION; POPULATION;
   EVENTS
AB Objective: Autonomic nervous system (ANS) activity decrease has been associated with a higher risk of sudden cardiovascular and cerebrovascular disease. Thus, we explored the relationship between ANS control of the cardiovascular system and metabolic syndrome.
   Methods: We analyzed the relationship with both short-term and long-term heart rate variability (HRV) and metabolic syndrome in the cross-sectional PROgnostic indicator OF cardiovascular and cerebrovascular events (PROOF) cohort study of 1,011 elderly subjects recruited amongst the inhabitants of the city of Saint Etienne, France, aged 65.6 +/- 0.8 years at the inclusion date. Physical examination included measurements of height, weight, systolic and diastolic blood pressure, waist circumference, and biological parameters. HRV variables were measured over 5-min, nighttime, and 24-h periods using Holter monitoring.
   Results: After adjustment for current type 2 diabetes, depression, and smoking, we found that metabolic syndrome status, high-density lipoprotein cholesterol (HDL-C), and waist circumference were significantly (p<0.05) associated with total power, very-low frequency, low-frequency/high-frequency (LF/HF) ratio, and normalized LF. HDL-C and metabolic syndrome status were significantly associated with decreased long-term HRV variables. Both nighttime and 24-h HRV showed closer associations with metabolic syndrome than did short-term HRV (5-min). Metabolic syndrome severity was associated with a decrease in both the long-term and short-term HRV variables.
   Conclusions: ANS control alteration of the cardiovascular system was more pronounced when evaluated by long-term than short-term HRV recordings, particularly in women.
C1 [Assoumou, H. G. Ntougou; Pichot, V.; Barthelemy, J. C.; Celle, S.; Gosse, P.; Roche, F.] Univ Hosp, Exercise & Clin Physiol Lab, SNA EPIS Res Unit, St Etienne, France.
   [Assoumou, H. G. Ntougou; Pichot, V.; Barthelemy, J. C.; Celle, S.; Gosse, P.; Roche, F.] Univ St Etienne, St Etienne, France.
   [Dauphinot, V.] Univ Med Hosp Lyon, Res Memory Ctr, Neurol Unit D, Pres Lyon, France.
   [Kossovsky, M.; Gaspoz, J. M.] Univ Hosp Geneva, Dept Community Med & Primary Care, Geneva, Switzerland.
   [Kossovsky, M.; Gaspoz, J. M.] Univ Geneva, Sch Med, CH-1211 Geneva, Switzerland.
C3 CHU de St Etienne; Universite Jean Monnet; University of Geneva;
   University of Geneva
RP Assoumou, HGN (corresponding author), CHU Nord, Serv Physiol Clin & Exercice, Niveau 6, F-42055 St Etienne 2, France.
EM gabingabon@hotmail.com
RI Dauphinot, Virginie/ABD-5349-2020; pichot, vincent/KDM-7133-2024; ,
   Gosse/I-3950-2019; Barthelemy, Jean-Claude/AAE-7180-2019
OI gosse, philippe/0000-0002-5840-7749; Pichot,
   Vincent/0000-0002-0832-4961; Roche, Frederic/0000-0001-6115-7958;
   Barthelemy, Jean-Claude/0000-0003-4306-7275
FU French Ministry of Health; AG2R; MPCL; Association SYNAPSE; Mutual
   Insurance Companies
FX The PROOF study was made possible through three consecutive grants from
   the French Ministry of Health (Programmes Hospitaliers de Recherche
   Clinique: PHRC National PROOF, 1998; PHRC National SYNAPSE, 2002; PHRC
   Regional Telamons, 2003). The study was also funded through grants from
   Mutual Insurance Companies, AG2R, and MPCL. Additional funding came from
   the Association SYNAPSE (Michel Segura). ClinicalTrials.gov number, NCT
   00759304.
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NR 42
TC 68
Z9 69
U1 0
U2 7
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1549-1684
EI 1557-8577
J9 REJUV RES
JI Rejuv. Res.
PD DEC
PY 2010
VL 13
IS 6
BP 653
EP 663
DI 10.1089/rej.2010.1019
PG 11
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA 708RY
UT WOS:000286383200004
PM 20818933
DA 2025-06-11
ER

PT J
AU Kokkeler, KJE
   Marijnissen, RM
   Wardenaar, KJ
   Rhebergen, D
   van den Brink, RHS
   van der Mast, RC
   Voshaar, RCO
AF Kokkeler, K. J. E.
   Marijnissen, R. M.
   Wardenaar, K. J.
   Rhebergen, D.
   van den Brink, R. H. S.
   van der Mast, R. C.
   Oude Voshaar, R. C.
TI Subtyping late-life depression according to inflammatory and metabolic
   dysregulation: a prospective study
SO PSYCHOLOGICAL MEDICINE
LA English
DT Article
DE Aged; depression; inflammation; latent class analysis; metabolic
   syndrome
ID C-REACTIVE PROTEIN; MAJOR DEPRESSION; SYMPTOM PROFILES; ASSOCIATION;
   ANXIETY; METAANALYSIS; IDENTIFICATION; NETHERLANDS; RELIABILITY;
   DISORDERS
AB Background Inflammation and metabolic dysregulation are age-related physiological changes and are associated with depressive disorder. We tried to identify subgroups of depressed older patients based on their metabolic-inflammatory profile and examined the course of depression for these subgroups. Methods This clinical cohort study was conducted in a sample of 364 depressed older (> 60 years) patients according to DSM-IV criteria. Severity of depressive symptoms was monitored every 6 months and a formal diagnostic interview repeated at 2-year follow-up. Latent class analyses based on baseline metabolic and inflammatory biomarkers were performed. Adjusted for confounders, we compared remission of depression at 2-year follow-up between the metabolic-inflammatory subgroups with logistic regression and the course of depression severity over 2-years by linear mixed models. Results We identified a 'healthy' subgroup (n = 181, 49.7%) and five subgroups characterized by different profiles of metabolic-inflammatory dysregulation. Compared to the healthy subgroup, patients in the subgroup with mild 'metabolic and inflammatory dysregulation' (n = 137, 37.6%) had higher depressive symptom scores, a lower rate of improvement in the first year, and were less likely to be remitted after 2-years [OR 0.49 (95% CI 0.26-0.91)]. The four smaller subgroups characterized by a more specific immune-inflammatory dysregulation profile did not differ from the two main subgroups regarding the course of depression. Conclusions Nearly half of the patients with late-life depressions suffer from metabolic-inflammatory dysregulation, which is also associated with more severe depression and a worse prognosis. Future studies should examine whether these depressed older patients benefit from a metabolic-inflammatory targeted treatment.
C1 [Kokkeler, K. J. E.] ProPersona, Dept Old Age Psychiat, Arnhem, Wolfheze, Netherlands.
   [Kokkeler, K. J. E.; Marijnissen, R. M.; Wardenaar, K. J.; van den Brink, R. H. S.; Oude Voshaar, R. C.] Univ Groningen, Univ Med Ctr Groningen, Univ Ctr Psychiat, Groningen, Netherlands.
   [Kokkeler, K. J. E.; Marijnissen, R. M.; Wardenaar, K. J.; van den Brink, R. H. S.; Oude Voshaar, R. C.] Univ Groningen, Univ Med Ctr Groningen, Interdisciplinary Ctr Psychopathol Emot Regulat, Groningen, Netherlands.
   [Rhebergen, D.] Vrije Univ Amsterdam, Med Ctr, Amsterdam Publ Hlth Res Inst, Dept Psychiat,GGZinGeest, Amsterdam, Netherlands.
   [van der Mast, R. C.] Leiden Univ, Med Ctr, Dept Psychiat, Leiden, Netherlands.
   [van der Mast, R. C.] Univ Antwerp, CAPRI, Dept Psychiat, Antwerp, Belgium.
C3 University of Groningen; University of Groningen; Vrije Universiteit
   Amsterdam; Leiden University - Excl LUMC; Leiden University; Leiden
   University Medical Center (LUMC); University of Antwerp
RP Kokkeler, KJE (corresponding author), ProPersona, Dept Old Age Psychiat, Arnhem, Wolfheze, Netherlands.; Kokkeler, KJE (corresponding author), Univ Groningen, Univ Med Ctr Groningen, Univ Ctr Psychiat, Groningen, Netherlands.; Kokkeler, KJE (corresponding author), Univ Groningen, Univ Med Ctr Groningen, Interdisciplinary Ctr Psychopathol Emot Regulat, Groningen, Netherlands.
EM k.kokkeler@propersona.nl
RI Wardenaar, Klaas/E-2985-2013
OI Oude Voshaar, Richard/0000-0003-1501-4774
FU Fonds NutsOhra; Stichting tot Steun VCVGZ; NARSAD The Brain and
   Behaviour Research Fund; VU University Medical Center; Leiden University
   Medical Center; University Medical Center Groningen; Radboud University
   Nijmegen Medical Center; GGZ inGeest; GGNet; GGZ Nijmegen; Parnassia
FX The infrastructure for NESDO is funded through the Fonds NutsOhra,
   Stichting tot Steun VCVGZ, NARSAD The Brain and Behaviour Research Fund,
   and the participating universities and mental health care organizations
   (VU University Medical Center, Leiden University Medical Center,
   University Medical Center Groningen, Radboud University Nijmegen Medical
   Center, and GGZ inGeest, GGNet, GGZ Nijmegen, and Parnassia).
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NR 58
TC 19
Z9 20
U1 2
U2 28
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0033-2917
EI 1469-8978
J9 PSYCHOL MED
JI Psychol. Med.
PD FEB
PY 2022
VL 52
IS 3
BP 515
EP 525
AR PII S0033291720002159
DI 10.1017/S0033291720002159
PG 11
WC Psychology, Clinical; Psychiatry; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA ZG5YM
UT WOS:000760333800013
PM 32618234
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Sakboonyarat, B
   Poovieng, J
   Jongcherdchootrakul, K
   Srisawat, P
   Hatthachote, P
   Mungthin, M
   Rangsin, R
AF Sakboonyarat, Boonsub
   Poovieng, Jaturon
   Jongcherdchootrakul, Kanlaya
   Srisawat, Phutsapong
   Hatthachote, Panadda
   Mungthin, Mathirut
   Rangsin, Ram
TI Prevalence of hypertriglyceridemia among Royal Thai Army personnel and
   its related cardiometabolic risk factors, from 2017 to 2021
SO BMC PUBLIC HEALTH
LA English
DT Article
DE Hypertriglyceridemia; Behavioral risk; Cardiometabolic risk; RTA;
   Thailand
ID CORONARY-HEART-DISEASE; OXIDATIVE STRESS; MYOCARDIAL-INFARCTION;
   CIGARETTE-SMOKING; BLOOD-PRESSURE; STROKE; MANAGEMENT; TRIGLYCERIDES;
   DYSLIPIDEMIA; DYSFUNCTION
AB Background Hypertriglyceridemia is a common health problem independently associated with an increased risk of atherosclerosis cardiovascular diseases (ASCVD), including ischemic heart disease and stroke. This study aims to determine the prevalence of hypertriglyceridemia among Royal Thai Army (RTA) personnel and its behavioral and cardiometabolic risk factors using the RTA personnel database of the physical health examination from 2017 to 2021. Methods A serial cross-sectional study was conducted from 2017 to 2021. A total of 257,683 active-duty RTA personnel aged 35-60 years were included in the study. We defined hypertriglyceridemia as fasting triglyceride >= 150 mg/dL. Moreover, we performed a multivariable logistic regression analysis to investigate behavioral and cardiometabolic risk factors for the prevalence of hypertriglyceridemia. The magnitude of the association was presented as an adjusted odds ratio (AOR) with a 95% confidence interval (CI). Results The hypertriglyceridemia prevalence among RTA personnel was 43.4% (95% CI: 42.9-43.8%) in 2017. It then continuously decreased to 40.3% (95% CI: 39.9-40.7%) in 2020 and slightly rose to 41.0% (95% CI: 40.6-41.4%) in 2021 (p for trend < 0.001). The prevalence of hypertriglyceridemia was higher for males than females (AOR 2.15; 95% CI: 2.07-2.23); RTA personnel aged 40-44 years compared with those aged 35-39 years (AOR 1.05; 95% CI: 1.02-1.08); and RTA personnel residing in the northeast (AOR; 1.15 95% CI: 1.11-1.18) and the north (AOR 1.05; 95% CI: 1.02-1.08) compared with those residing in Bangkok. The independent behavioral factors associated with hypertriglyceridemia included alcohol consumption, smoking, and sedentary behavior. Moreover, cardiometabolic risk factors, including higher body mass index, high fasting plasma glucose (>= 100 mg/dL), high blood pressure (>= 140/90 mmHg), and hypercholesterolemia (>= 200 mg/dL), were significantly related to hypertriglyceridemia. Conclusion Our data demonstrated that hypertriglyceridemia is a frequent health issue, especially among males, participants aged 40-44 years, and RTA personnel residing in the northeast and the north. The prevalence of hypertriglyceridemia in this population was greatly influenced by alcohol consumption, cigarette smoking, and sedentary behavior. Both behavioral and cardiometabolic risk factors are potential targets for intervention to enhance the primary prevention of sequelae of hypertriglyceridemia, including ASCVD.
C1 [Sakboonyarat, Boonsub; Jongcherdchootrakul, Kanlaya; Srisawat, Phutsapong; Rangsin, Ram] Phramongkutklao Coll Med, Dept Mil & Community Med, Bangkok 10400, Thailand.
   [Poovieng, Jaturon] Phramongkutkalo Coll Med, Dept Med, Bangkok 10400, Thailand.
   [Hatthachote, Panadda] Phramongkutklao Coll Med, Dept Physiol, Bangkok 10400, Thailand.
   [Mungthin, Mathirut] Phramongkutklao Coll Med, Dept Parasitol, Bangkok 10400, Thailand.
C3 Phramongkutklao College of Medicine; Phramongkutklao College of
   Medicine; Phramongkutklao College of Medicine
RP Rangsin, R (corresponding author), Phramongkutklao Coll Med, Dept Mil & Community Med, Bangkok 10400, Thailand.
EM r_rangsin@yahoo.com
RI Rangsin, Ram/AAW-9527-2020; Sakboonyarat, Boonsub/ISU-4684-2023
OI Sakboonyarat, Boonsub/0000-0003-0577-0699
FU FETP-NCD, Division of Epidemiology, Department of Disease Control,
   Ministry of Public Health, Thailand; Research Unit for Military
   Medicine, Phramongkutklao College of Medicine, Bangkok, Thailand
FX This research was supported by (1) the FETP-NCD, Division of
   Epidemiology, Department of Disease Control, Ministry of Public Health,
   Thailand and (2) the Research Unit for Military Medicine,
   Phramongkutklao College of Medicine, Bangkok, Thailand.
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NR 70
TC 10
Z9 10
U1 0
U2 6
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2458
J9 BMC PUBLIC HEALTH
JI BMC Public Health
PD AUG 17
PY 2022
VL 22
IS 1
AR 1569
DI 10.1186/s12889-022-13992-2
PG 15
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA 3W5TS
UT WOS:000842407600007
PM 35978422
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Doom, JR
   Rivera, KM
   Blanco, E
   Burrows, R
   Correa-Burrows, P
   East, PL
   Lozoff, B
   Gahagan, S
AF Doom, Jenalee R.
   Rivera, Kenia M.
   Blanco, Estela
   Burrows, Raquel
   Correa-Burrows, Paulina
   East, Patricia L.
   Lozoff, Betsy
   Gahagan, Sheila
TI Sensitive periods for psychosocial risk in childhood and adolescence and
   cardiometabolic outcomes in young adulthood
SO DEVELOPMENT AND PSYCHOPATHOLOGY
LA English
DT Article; Proceedings Paper
CT 41st Minnesota Symposium on Child Psychology
CY OCT 24-25, 2019
CL Minneapolis, MN
DE cardiometabolic risk; infancy; metabolic syndrome; psychosocial risk;
   young adulthood
ID MEASURING SOCIOECONOMIC-STATUS; IRON-DEFICIENCY ANEMIA; EARLY-LIFE
   ADVERSITY; PHYSICAL HEALTH; BLOOD-PRESSURE; HEART-DISEASE; STRESS;
   OBESITY; ABUSE; DETERMINANTS
AB Greater psychosocial risk in childhood and adolescence predicts poorer cardiometabolic outcomes in adulthood. We assessed whether the timing of psychosocial risk from infancy through adolescence predicts cardiometabolic outcomes in young adulthood. Young adults and their mothers participated in a longitudinal study beginning in infancy in Santiago, Chile (N = 1040). At infancy, 5 years, 10 years, and adolescence, mothers reported on depressive symptoms, stressful experiences, support for child development in the home, father absence, parental education, and socioeconomic status (SES) to create a psychosocial risk composite at each time point. Young adults (52.1% female; 21-27 years) provided fasting serum samples and participated in anthropometric and blood pressure (BP) assessments, including a dual-energy X-ray absorptiometry (DXA) scan for measuring body fat. Greater infant psychosocial risk was associated with a greater young adult metabolic syndrome score (beta = 0.07, 95% confidence intervals (CI): 0.01 to 0.13, p = 0.02), a higher body mass index and waist circumference composite (beta = 0.08, 95% CI: 0.03 to 0.13, p = 0.002), and a higher body fat (DXA) composite (beta = 0.07, 95% CI: 0.01 to 0.12, p = 0.02). No psychosocial risk measure from any time point was associated with BP. Infant psychosocial risk predicted cardiometabolic outcomes in young adulthood better than psychosocial risk at 5 years, 10 years, or adolescence, mean of psychosocial risk from infancy through adolescence, and maximum of psychosocial risk at any one time. Consistent with the Developmental Origins of Health and Disease model, findings suggest that infancy is a sensitive period for psychosocial risk leading to poorer cardiometabolic outcomes in young adulthood.
C1 [Doom, Jenalee R.; Rivera, Kenia M.] Univ Denver, Dept Psychol, Denver, CO 80208 USA.
   [Blanco, Estela] Univ Chile, Publ Hlth PhD Program, Santiago, Chile.
   [Blanco, Estela; East, Patricia L.; Gahagan, Sheila] Univ Calif San Diego, Dept Pediat, San Diego, CA 92103 USA.
   [Burrows, Raquel; Correa-Burrows, Paulina] Univ Chile, INTA, Santiago, Chile.
   [Lozoff, Betsy] Univ Michigan, Dept Pediat, Ann Arbor, MI 48109 USA.
   [Lozoff, Betsy] Univ Michigan, Ctr Human Growth & Dev, Ann Arbor, MI 48109 USA.
C3 University of Denver; Universidad de Chile; University of California
   System; University of California San Diego; Universidad de Chile;
   University of Michigan System; University of Michigan; University of
   Michigan System; University of Michigan
RP Doom, JR (corresponding author), Univ Denver, Frontier Hall,2155 S Race St, Denver, CO 80210 USA.
EM Jena.Doom@du.edu
RI Burrows, Raquel/A-8489-2015; Blanco, Estela/AAI-9276-2021; Blanco,
   Estela/A-2541-2014; Correa-Burrows, Paulina/O-7436-2014
OI Blanco, Estela/0000-0002-6232-9210; Correa-Burrows,
   Paulina/0000-0002-6177-1162
FU [F32HD088029];  [K0IHLI43159];  [R0IHDI4122];  [R0IHD33487]; 
   [R0IHL088530]
FX Funding from F32HD088029 (PI: Doom), K0IHLI43159 (PI: Doom), R0IHDI4122
   (PI: Lozoff), R0IHD33487 (PI: Lozoff & Gahagan), and R0IHL088530 (PI:
   Gahagan).
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NR 65
TC 11
Z9 11
U1 2
U2 11
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
SN 0954-5794
EI 1469-2198
J9 DEV PSYCHOPATHOL
JI Dev. Psychopathol.
PD DEC
PY 2020
VL 32
IS 5
SI SI
BP 1864
EP 1875
AR PII S0954579420001248
DI 10.1017/S0954579420001248
PG 12
WC Psychology, Developmental
WE Social Science Citation Index (SSCI); Conference Proceedings Citation Index - Social Science &amp; Humanities (CPCI-SSH)
SC Psychology
GA PR5SB
UT WOS:000607295100023
PM 33427189
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Dinel, AL
   André, C
   Aubert, A
   Ferreira, G
   Layé, S
   Castanon, N
AF Dinel, Anne-Laure
   Andre, Caroline
   Aubert, Agnes
   Ferreira, Guillaume
   Laye, Sophie
   Castanon, Nathalie
TI Cognitive and Emotional Alterations Are Related to Hippocampal
   Inflammation in a Mouse Model of Metabolic Syndrome
SO PLOS ONE
LA English
DT Article
ID LONG-TERM POTENTIATION; SPATIAL MEMORY; INDOLEAMINE 2,3-DIOXYGENASE;
   PROINFLAMMATORY CYTOKINES; BEHAVIORAL DEPRESSION; OBJECT RECOGNITION;
   CALMETTE-GUERIN; TRANSGENIC MICE; MOOD DISORDERS; MESSENGER-RNA
AB Converging clinical data suggest that peripheral inflammation is likely involved in the pathogenesis of the neuropsychiatric symptoms associated with metabolic syndrome (MetS). However, the question arises as to whether the increased prevalence of behavioral alterations in MetS is also associated with central inflammation, i.e. cytokine activation, in brain areas particularly involved in controlling behavior. To answer this question, we measured in a mouse model of MetS, namely the diabetic and obese db/db mice, and in their healthy db/+ littermates emotional behaviors and memory performances, as well as plasma levels and brain expression (hippocampus; hypothalamus) of inflammatory cytokines. Our results shows that db/db mice displayed increased anxiety-like behaviors in the open-field and the elevated plus-maze (i.e. reduced percent of time spent in anxiogenic areas of each device), but not depressive-like behaviors as assessed by immobility time in the forced swim and tail suspension tests. Moreover, db/db mice displayed impaired spatial recognition memory (hippocampus-dependent task), but unaltered object recognition memory (hippocampus-independent task). In agreement with the well-established role of the hippocampus in anxiety-like behavior and spatial memory, behavioral alterations of db/db mice were associated with increased inflammatory cytokines (interleukin-1 beta, tumor necrosis factor-alpha and interleukin-6) and reduced expression of brain-derived neurotrophic factor (BDNF) in the hippocampus but not the hypothalamus. These results strongly point to interactions between cytokines and central processes involving the hippocampus as important contributing factor to the behavioral alterations of db/db mice. These findings may prove valuable for introducing novel approaches to treat neuropsychiatric complications associated with MetS.
C1 [Dinel, Anne-Laure; Andre, Caroline; Aubert, Agnes; Ferreira, Guillaume; Laye, Sophie; Castanon, Nathalie] INRA, UMR 1286, Bordeaux, France.
   [Dinel, Anne-Laure; Andre, Caroline; Aubert, Agnes; Ferreira, Guillaume; Laye, Sophie; Castanon, Nathalie] Univ Bordeaux, Bordeaux, France.
C3 INRAE; Institut National de la Sante et de la Recherche Medicale
   (Inserm); Universite de Bordeaux; Universite de Bordeaux
RP Dinel, AL (corresponding author), INRA, UMR 1286, Bordeaux, France.
EM nathalie.castanon@bordeaux.inra.fr
RI Laye, Sophie/AAX-2501-2020
OI Ferreira, Guillaume/0000-0001-5984-8143; Laye,
   Sophie/0000-0002-3843-1012; Castanon, Nathalie/0000-0002-0079-0562
FU Institut National de la Recherche Agronomique; Region Aquitaine
   [2008-1301-038]; Institut Danone
FX This work was supported by Institut National de la Recherche Agronomique
   and Region Aquitaine (grant number 2008-1301-038; SL). ALD was supported
   by a doctoral fellowship from the Institut Danone. The funders had no
   role in study design, data collection and analysis, decision to publish,
   or preparation of the manuscript.
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NR 87
TC 208
Z9 239
U1 1
U2 14
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD SEP 16
PY 2011
VL 6
IS 9
AR e24325
DI 10.1371/journal.pone.0024325
PG 10
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 824BI
UT WOS:000295173800017
PM 21949705
OA gold, Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Newsome, AM
AF Newsome, A'Naja M.
TI Exercise Promotion Practices among Mental Health Professionals: A
   Scoping Review
SO ISSUES IN MENTAL HEALTH NURSING
LA English
DT Review
ID MAJOR DEPRESSIVE DISORDER; PHYSICAL-ACTIVITY; METABOLIC SYNDROME;
   MOTIVATIONAL INTERVENTION; CLINICIAN PERSPECTIVES; PSYCHOTIC DISORDERS;
   CARE PROFESSIONALS; BIPOLAR DISORDER; NURSES WORKING; LIFE-STYLE
AB Mental health professionals (MHPs) have a unique opportunity to integrate PA and exercise promotion into clinical care. This scoping review employed the information-motivation-behavioral Skills (IMB) model to examine the exercise promotion practices of MHP. An electronic search of four major databases from 2007 to August 2020 was conducted and results were reported using PRISMA. Seventeen studies were included where the variables of interest were knowledge, attitudes, and beliefs regarding exercise promotion. MHP expressed a need for additional training and the integration of exercise specialists to care for the physical health of patients. Practitioners need additional education to understand the guidelines for exercise prescription for individuals with SMI and the role exercise could have in improving the quality of life for their patients. Findings were conceptualized utilizing the IMB model to inform future quantitative measures and health behavior interventions.
C1 [Newsome, A'Naja M.] Univ Cent Florida, Dept Hlth Sci, Orlando, FL USA.
   [Newsome, A'Naja M.] 4000 Cent Florida Blvd, Orlando, FL 32816 USA.
C3 State University System of Florida; University of Central Florida
RP Newsome, AM (corresponding author), 4000 Cent Florida Blvd, Orlando, FL 32816 USA.
EM anaja.newsome@ucf.edu
OI Newsome, A'Naja/0000-0002-4916-0705
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NR 68
TC 4
Z9 4
U1 2
U2 6
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 0161-2840
EI 1096-4673
J9 ISSUES MENT HEALTH N
JI Issues Ment. Health Nurs.
PD JUL 3
PY 2023
VL 44
IS 7
BP 591
EP 601
DI 10.1080/01612840.2023.2212770
EA MAY 2023
PG 11
WC Nursing; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Psychiatry
GA N5MZ3
UT WOS:001005909500001
PM 37315310
DA 2025-06-11
ER

PT J
AU Maestre, GE
AF Maestre, Gladys E.
TI Assessing Dementia in Resource-Poor Regions
SO CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS
LA English
DT Review
DE Developing countries; Low-to-middle-income countries; Resource-poor;
   Population demography; Elderly; Dementia; Prevalence; Diagnosis;
   Capacity building; Challenges; Obstacles; International partnerships;
   Cost-benefit analysis; Economics; Ethics
ID ALZHEIMERS ASSOCIATION WORKGROUPS; MENTAL-HEALTH-SERVICES; DIAGNOSTIC
   GUIDELINES; NATIONAL INSTITUTE; PRIMARY-CARE; GENERAL-PRACTITIONERS;
   DEVELOPING-COUNTRIES; METABOLIC SYNDROME; ELDERLY-PEOPLE; LATIN-AMERICA
AB The numbers and proportions of elderly are increasing rapidly in developing countries, where prevalence of dementia is often high. Providing cost-effective services for dementia sufferers and their caregivers in these resource-poor regions poses numerous challenges; developing resources for diagnosis must be the first step. Capacity building for diagnosis involves training and education of healthcare providers, as well as the general public, development of infrastructure, and resolution of economic and ethical issues. Recent progress in some low-to-middle-income countries (LMICs) provides evidence that partnerships between wealthy and resource-poor countries, and between developing countries, can improve diagnostic capabilities. Without the involvement of the mental health community of developed countries in such capacity-building programs, dementia in the developing world is a disaster waiting to happen.
C1 [Maestre, Gladys E.] Univ Zulia, Neurosci Lab, Maracaibo 4002, Zulia, Venezuela.
   [Maestre, Gladys E.] Columbia Univ, Dept Psychiat, New York, NY 10032 USA.
   [Maestre, Gladys E.] Columbia Univ, Dept Neurol, New York, NY 10032 USA.
   [Maestre, Gladys E.] Columbia Univ, Gertrude H Sergievsky Ctr, New York, NY 10032 USA.
C3 Columbia University; Columbia University; Columbia University
RP Maestre, GE (corresponding author), Univ Zulia, Neurosci Lab, Edificio Inst Enfermedades Cardiovasc,Av Univ Dia, Maracaibo 4002, Zulia, Venezuela.
EM gem6@columbia.edu
RI , Gladys/L-5092-2015
OI , Gladys/0000-0001-5690-8833
FU National Institute on Aging [R01AG036469]
FX The author has no conflicts of interest to disclose. G. E. M. is funded
   by Award Number R01AG036469 from the National Institute on Aging.
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   [No title captured]
NR 100
TC 42
Z9 50
U1 0
U2 17
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1528-4042
EI 1534-6293
J9 CURR NEUROL NEUROSCI
JI Curr. Neurol. Neurosci. Rep.
PD OCT
PY 2012
VL 12
IS 5
BP 511
EP 519
DI 10.1007/s11910-012-0300-9
PG 9
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology
GA 001DG
UT WOS:000308439700004
PM 22864986
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Koenen, KC
   Sumner, JA
   Gilsanz, P
   Glymour, MM
   Ratanatharathorn, A
   Rimm, EB
   Roberts, AL
   Winning, A
   Kubzansky, LD
AF Koenen, K. C.
   Sumner, J. A.
   Gilsanz, P.
   Glymour, M. M.
   Ratanatharathorn, A.
   Rimm, E. B.
   Roberts, A. L.
   Winning, A.
   Kubzansky, L. D.
TI Post-traumatic stress disorder and cardiometabolic disease: improving
   causal inference to inform practice
SO PSYCHOLOGICAL MEDICINE
LA English
DT Review
DE Cardiovascular disease; causality; diabetes; post-traumatic stress
   disorder
ID ADVERSE CHILDHOOD EXPERIENCES; MAJOR DEPRESSIVE DISORDER;
   CORONARY-HEART-DISEASE; TYPE-2 DIABETES-MELLITUS;
   CARDIOVASCULAR-DISEASE; VIETNAM VETERANS; BIDIRECTIONAL ASSOCIATION;
   DIMENSIONAL STRUCTURE; METABOLIC SYNDROME; COMBAT DEPLOYMENT
AB Post-traumatic stress disorder (PTSD) has been declared ` a life sentence' based on evidence that the disorder leads to a host of physical health problems. Some of the strongest empirical research - in terms of methodology and findings - has shown that PTSD predicts higher risk of cardiometabolic diseases, specifically cardiovascular disease (CVD) and type 2 diabetes (T2D). Despite mounting evidence, PTSD is not currently acknowledged as a risk factor by cardiovascular or endocrinological medicine. This view is unlikely to change absent compelling evidence that PTSD causally contributes to cardiometabolic disease. This review suggests that with developments in methods for epidemiological research and the rapidly expanding knowledge of the behavioral and biological effects of PTSD the field is poised to provide more definitive answers to questions of causality. First, we discuss methods to improve causal inference using the observational data most often used in studies of PTSD and health, with particular reference to issues of temporality and confounding. Second, we consider recent work linking PTSD with specific behaviors and biological processes, and evaluate whether these may plausibly serve as mechanisms by which PTSD leads to cardiometabolic disease. Third, we evaluate how looking more comprehensively into the PTSD phenotype provides insight into whether specific aspects of PTSD phenomenology are particularly relevant to cardiometabolic disease. Finally, we discuss new areas of research that are feasible and could enhance understanding of the PTSD-cardiometabolic relationship, such as testing whether treatment of PTSD can halt or even reverse the cardiometabolic risk factors causally related to CVD and T2D.
C1 [Koenen, K. C.; Sumner, J. A.; Ratanatharathorn, A.] Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, 677 Huntington Ave,Kresge 505, Boston, MA 02115 USA.
   [Koenen, K. C.] Massachusetts Gen Hosp, Psychiat & Neurodev Genet Unit, Boston, MA 02114 USA.
   [Koenen, K. C.] Massachusetts Gen Hosp, Dept Psychiat, Boston, MA 02114 USA.
   [Sumner, J. A.] Columbia Univ, Med Ctr, Ctr Behav Cardiovasc Hlth, New York, NY 10025 USA.
   [Gilsanz, P.; Glymour, M. M.; Roberts, A. L.; Winning, A.; Kubzansky, L. D.] Harvard TH Chan Sch Publ Hlth, Dept Social & Behav Sci, Boston, MA USA.
   [Glymour, M. M.] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA.
   [Ratanatharathorn, A.] Columbia Univ, Mailman Sch Publ Hlth, Dept Epidemiol, New York, NY USA.
   [Rimm, E. B.] Harvard Med Sch, Brigham & Womens Hosp, Channing Div Network Med, Boston, MA USA.
   [Rimm, E. B.] Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.
   [Rimm, E. B.] Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA.
C3 Harvard University; Harvard T.H. Chan School of Public Health; Harvard
   University; Harvard University Medical Affiliates; Massachusetts General
   Hospital; Harvard University; Harvard University Medical Affiliates;
   Massachusetts General Hospital; Columbia University; Harvard University;
   Harvard T.H. Chan School of Public Health; University of California
   System; University of California San Francisco; Columbia University;
   Harvard University; Harvard Medical School; Harvard University Medical
   Affiliates; Brigham & Women's Hospital; Harvard University; Harvard T.H.
   Chan School of Public Health; Harvard University; Harvard T.H. Chan
   School of Public Health
RP Koenen, KC (corresponding author), Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, 677 Huntington Ave,Kresge 505, Boston, MA 02115 USA.
EM kkoenen@hsph.harvard.edu
RI Koenen, Karestan/K-5402-2014; Glymour, Maria/AEM-8841-2022
OI Koenen, Karestan/0000-0003-2978-7655
FU National Institutes of Health [R01MH078928, R01MH101269, UM1CA176726,
   K01HL130650, T32MH017119]; Yerby Postdoctoral Fellowship Program;
   National Institute on Aging [T32AG049663] Funding Source: NIH RePORTER
FX This work was supported by the National Institutes of Health (to K.C.K.,
   R01MH078928; to K.C.K., L.D. K. and A.W., R01MH101269; NHS II
   infrastructure, UM1CA176726; to J.A.S., K01HL130650; and to P.G.,
   T32MH017119) and by the Yerby Postdoctoral Fellowship Program (to P.G.).
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NR 124
TC 104
Z9 118
U1 0
U2 28
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
SN 0033-2917
EI 1469-8978
J9 PSYCHOL MED
JI Psychol. Med.
PD JAN
PY 2017
VL 47
IS 2
BP 209
EP 225
DI 10.1017/S0033291716002294
PG 17
WC Psychology, Clinical; Psychiatry; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA EG8PU
UT WOS:000391320100003
PM 27697083
OA Green Accepted, Green Submitted
DA 2025-06-11
ER

PT J
AU Oxenkrug, GF
AF Oxenkrug, Gregory F.
TI Interferon-gamma-inducible kynurenines/pteridines inflammation cascade:
   implications for aging and aging-associated psychiatric and medical
   disorders
SO JOURNAL OF NEURAL TRANSMISSION
LA English
DT Review
DE Interferon-gamma; Neopterin; Kynurenines; Metabolic syndrome; Aging;
   Aging-associated disorders; Major depression
ID NITRIC-OXIDE SYNTHASE; TRYPTOPHAN-KYNURENINE METABOLISM; SINGLE
   NUCLEOTIDE POLYMORPHISM; INFLUENCING SERUM NEOPTERIN; MAJOR DEPRESSIVE
   DISORDER; CHRONIC IMMUNE ACTIVATION; INDOLEAMINE 2,3-DIOXYGENASE;
   N-ACETYLSEROTONIN; IFN-GAMMA; CARDIOVASCULAR RISK
AB This review of literature and our data suggests that up-regulated production of interferon-gamma (IFNG) in periphery and brain triggers a merger of tryptophan (TRY)-kynurenine (KYN) and guanine-tetrahydrobiopterin (BH4) metabolic pathways into inflammation cascade involved in aging and aging-associated medical and psychiatric disorders (AAMPD) (metabolic syndrome, depression, vascular cognitive impairment). IFNG-inducible KYN/pteridines inflammation cascade is characterized by up-regulation of nitric oxide synthase (NOS) activity (induced by KYN) and decreased formation of NOS cofactor, BH4, that results in uncoupling of NOS that shifting arginine from NO to superoxide anion production. Superoxide anion and free radicals among KYN derivatives trigger phospholipase A2-arachidonic acid cascade associated with AAMPD. IFNG-induced up-regulation of indoleamine 2,3-dioxygenase (IDO), rate-limiting enzyme of TRY-KYN pathway, decreases TRY conversion into serotonin (substrate of antidepressant effect) and increases production of KYN associated with diabetes [xanthurenic acid (XA)], anxiety (KYN), psychoses and cognitive impairment (kynurenic acid). IFNG-inducible KYN/pteridines inflammation cascade is impacted by IFNG (+874) T/A genotypes, encoding cytokine production. In addition to literature data on KYN/TRY ratio (IDO activity index), we observe neopterin levels (index of activity of rate-limiting enzyme of guanine-BH4 pathway) to be higher in carriers of high (T) than of low (A) producers alleles; and to correlate with AAMPD markers (e.g., insulin resistance, body mass index, mortality risk), and with IFN-alpha-induced depression in hepatitis C patients. IFNG-inducible cascade is influenced by environmental factors (e.g., vitamin B6 deficiency increases XA formation) and by pharmacological agents; and might offer new approaches for anti-aging and anti-AAMPD interventions.
C1 Tufts Univ, Psychiat & Inflammat Program, Dept Psychiat, Tufts Med Ctr, Boston, MA 02111 USA.
C3 Tufts University; Tufts Medical Center
RP Oxenkrug, GF (corresponding author), Tufts Univ, Psychiat & Inflammat Program, Dept Psychiat, Tufts Med Ctr, Boston, MA 02111 USA.
EM goxenkrug@tuftsmedicalcenter.org
OI Oxenkrug, Gregory/0000-0002-7193-9117
FU NIH [MH083225]
FX This paper was supported by NIH MH083225.
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NR 126
TC 96
Z9 108
U1 0
U2 24
PU SPRINGER WIEN
PI WIEN
PA SACHSENPLATZ 4-6, PO BOX 89, A-1201 WIEN, AUSTRIA
SN 0300-9564
EI 1435-1463
J9 J NEURAL TRANSM
JI J. Neural Transm.
PD JAN
PY 2011
VL 118
IS 1
BP 75
EP 85
DI 10.1007/s00702-010-0475-7
PG 11
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology
GA 711QE
UT WOS:000286605700008
PM 20811799
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Avogaro, A
   de Kreutzenberg, SV
   Federici, M
   Fadini, GP
AF Avogaro, Angelo
   de Kreutzenberg, Saula Vigili
   Federici, Massimo
   Fadini, Gian Paolo
TI The Endothelium Abridges Insulin Resistance to Premature Aging
SO JOURNAL OF THE AMERICAN HEART ASSOCIATION
LA English
DT Review
ID PROGENITOR-CELL SENESCENCE; LEUKOCYTE TELOMERE LENGTH;
   NECROSIS-FACTOR-ALPHA; OXIDATIVE STRESS; METABOLIC SYNDROME; LIFE-SPAN;
   GLYCEMIC CONTROL; CARDIOVASCULAR-DISEASE; DIABETIC-NEPHROPATHY;
   GENE-EXPRESSION
C1 [Avogaro, Angelo; de Kreutzenberg, Saula Vigili; Fadini, Gian Paolo] Univ Padua, Dept Med, I-35128 Padua, Italy.
   [Avogaro, Angelo; Fadini, Gian Paolo] Venetian Inst Mol Med, Padua, Italy.
   [Federici, Massimo] Univ Roma Tor Vergata, Dept Syst Med, Rome, Italy.
   [Federici, Massimo] Policlin Tor Vergata, Ctr Atherosclerosis, Rome, Italy.
C3 University of Padua; Veneto Institute Molecular Medicine; University of
   Rome Tor Vergata; University of Rome Tor Vergata; Policlin Tor Vergata
RP Avogaro, A (corresponding author), Univ Padua, Dept Med, Via Giustiniani 2, I-35128 Padua, Italy.
EM angelo.avogaro@unipd.it
RI Avogaro, Angelo/S-3808-2016; Fadini, Gian/M-4575-2019; FEDERICI,
   MASSIMO/G-9940-2012
OI FEDERICI, MASSIMO/0000-0003-4989-5194; AVOGARO,
   ANGELO/0000-0002-1177-0516; FADINI, GIAN PAOLO/0000-0002-6510-2097
FU PRIN (Progetti di rilevanza Nazionale); European Foundation of the Study
   of Diabetes
FX This work was supported, in part, by grants from PRIN (Progetti di
   rilevanza Nazionale) 2009, FP7-FLORINASH (Seventh Framework
   Programme-The role of intestinal microflora in nonalcoholic fatty liver
   disease), from FP7-EURHYTHDIA (Seventh Framework Programme-European
   Consortium of the Early Treatment of Diabetic Retinopathy; to Dr
   Federici), and from the European Foundation of the Study of Diabetes
   (Longevity gene pathways in the metabolic syndrome. Effects of AMPK
   activation in a cross-over clinical trial and in vitro; Dr Avogaro).
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NR 126
TC 25
Z9 27
U1 0
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2047-9980
J9 J AM HEART ASSOC
JI J. Am. Heart Assoc.
PD JUN
PY 2013
VL 2
IS 3
AR e000262
DI 10.1161/JAHA.113.000262
PG 11
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 243TH
UT WOS:000326340100006
PM 23917532
OA Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Zeinoddini, A
   Sorayani, M
   Hassanzadeh, E
   Arbabi, M
   Farokhnia, M
   Salimi, S
   Ghaleiha, A
   Akhondzadeh, S
AF Zeinoddini, Atefeh
   Sorayani, Maryam
   Hassanzadeh, Elmira
   Arbabi, Mohammad
   Farokhnia, Mehdi
   Salimi, Samrand
   Ghaleiha, Ali
   Akhondzadeh, Shahin
TI PIOGLITAZONE ADJUNCTIVE THERAPY FOR DEPRESSIVE EPISODE OF BIPOLAR
   DISORDER: A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL
SO DEPRESSION AND ANXIETY
LA English
DT Article
DE PPAR-gamma; pioglitazone; bipolar disorder; depression;
   thiazolidinedione; randomized controlled trial
ID FORCED SWIMMING TEST; PPAR-GAMMA; MAJOR DEPRESSION; RATING-SCALE;
   SYMPTOMS; MOOD; GUIDELINES; EFFICACY; RECEPTOR; UPDATE
AB BackgroundThe antidepressive effect of pioglitazone has been noted in patients with major depressive disorder in absence of metabolic syndrome. This study was conducted to evaluate the safety and efficacy of pioglitazone in patients with bipolar depression without concomitant metabolic syndrome or diabetes.
   MethodForty-eight outpatients with the diagnosis of bipolar I disorder and a major depressive episode participated in a parallel, randomized, double-blind, placebo-controlled trial, and 44 patients underwent 6-week treatment with either pioglitazone (30mg/day) or placebo as an adjunctive treatment to lithium. Therapeutic serum lithium levels of 0.6-0.8 mEq/L were required for two or more consecutive weeks immediately before starting pioglitazone and during the 6-week study. Patients were evaluated using Hamilton Depression Rating Scale (HDRS) and Young Mania Rating Scale (YMRS) at baseline and weeks 1, 2, 4, and 6. The primary outcome was to evaluate the efficacy of pioglitazone in improving the depressive symptoms.
   ResultGeneral linear model repeated measures showed significant effect for time x treatment interaction on the HDRS scores [F(2.78, 116.65) = 4.77, P = .005]. Significantly greater reduction was observed in HDRS scores in the pioglitazone group than the placebo group from baseline HDRS score at weeks 2, 4, and 6, P = .003, .006, and .006, respectively. No serious adverse event was observed.
   ConclusionThis study showed that pioglitazone could be a tolerable and effective adjunctive therapy for improving depressive symptoms in bipolar disorder without type 2 diabetes or metabolic syndrome.
C1 [Zeinoddini, Atefeh; Sorayani, Maryam; Hassanzadeh, Elmira; Arbabi, Mohammad; Farokhnia, Mehdi; Akhondzadeh, Shahin] Univ Tehran Med Sci, Roozbeh Hosp, Psychiat Res Ctr, Tehran, Iran.
   [Salimi, Samrand] Univ Tehran Med Sci, Baharloo Hosp, Tehran, Iran.
   [Ghaleiha, Ali] Hamadan Univ Med Sci, Res Ctr Behav Disorders & Subst Abuse, Hamadan, Iran.
C3 Tehran University of Medical Sciences; Roozbeh Hospital; Tehran
   University of Medical Sciences; Hamadan University of Medical Sciences
RP Akhondzadeh, S (corresponding author), Univ Tehran Med Sci, Roozbeh Psychiat Hosp, Psychiat Res Ctr, South Kargar St, Tehran 13337, Iran.
EM s.akhond@neda.net
RI Arbabi, Mohammad/AAT-7558-2021; Farokhnia, Mehdi/U-8051-2019;
   Akhondzadeh, Shahin/F-2914-2018; Ghaleiha, Ali/P-1105-2017
OI Zeinoddini, Atefeh/0000-0001-6747-5041; Akhondzadeh,
   Shahin/0000-0002-2277-5101; Ghaleiha, Ali/0000-0003-3037-2676;
   Farokhnia, Mehdi/0000-0003-0902-4212; Hassanzadeh,
   Elmira/0000-0003-4460-698X
FU Tehran University of Medical Sciences [16043]
FX Contract grant sponsor: Tehran University of Medical Sciences; Contract
   grant number: 16043.
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NR 32
TC 96
Z9 99
U1 0
U2 24
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1091-4269
EI 1520-6394
J9 DEPRESS ANXIETY
JI Depress. Anxiety
PD MAR
PY 2015
VL 32
IS 3
BP 167
EP 173
DI 10.1002/da.22340
PG 7
WC Psychology, Clinical; Psychiatry; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA CC6LD
UT WOS:000350475500003
PM 25620378
OA gold
DA 2025-06-11
ER

PT J
AU Tasliyurt, T
   Bilir, Y
   Sahin, S
   Seckin, HY
   Kaya, SU
   Sivgin, H
   Demir, AK
   Erdemir, F
AF Tasliyurt, T.
   Bilir, Y.
   Sahin, S.
   Seckin, H. Y.
   Kaya, S. U.
   Sivgin, H.
   Demir, A. K.
   Erdemir, F.
TI Erectile dysfunction in patients with psoriasis: potential impact of the
   metabolic syndrome
SO EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
LA English
DT Article
DE Metabolic syndrome; Psoriasis; Erectile dysfunction; Depression
ID QUALITY-OF-LIFE; MYOCARDIAL-INFARCTION; HEART-DISEASE; RISK; HEALTH;
   METAANALYSIS; ASSOCIATION; STROKE; INDEX; AREA
AB BACKGROUND: Psoriasis is a chronic inflammatory skin disease that affects up to 5.5% of world population and is associated with erectile dysfunction (ED). Aim of the present study was to investigate impact of metabolic syndrome (MetS) on association between psoriasis and ED as well as to improve our understanding of this association via studying other possible causes of ED such as psychological factors and disease effects.
   PATIENTS AND METHODS: The patient group included 37 male psoriasis patients and control group 28 healthy men. Severity of psoriasis was determined using Psoriasis Area and Severity Index (PASI), and ED was evaluated using International Index of Erectile Function (IIEF) Scale. Psychiatric state of the patients were determined using Beck Depression Inventory (BDI). MetS was diagnosed using the National Cholesterol Education Program Adult Treatment Panel III criteria.
   RESULTS: MetS, ED prevalence and BDI score were significantly higher in psoriasis patient group (p = 0.032, p = 0.018 and p < 0.001). Average IIEF score of psoriasis patients with and without MetS, on the other hand, was not different (p = 0.073). IIEF score had negative correlations with age, BDI and PASI scores. In multiple linear regression analysis, BDI score, old age and smoking (but not MetS) were found to be independent predictors of ED.
   CONCLUSIONS: ED, MetS and depression frequencies were significantly higher in psoriasis patient group. In addition, psoriasis severity and ED parameters were closely associated. Depression, old age and smoking were found to be independent risk factors for ED.
C1 [Tasliyurt, T.; Bilir, Y.; Sahin, S.; Kaya, S. U.; Sivgin, H.; Demir, A. K.] Tokat Gaziosmanpasa Univ, Fac Med, Dept Internal Med, Tokat, Turkey.
   [Seckin, H. Y.] Tokat Gaziosmanpasa Univ, Fac Med, Dept Dermatol, Tokat, Turkey.
   [Erdemir, F.] Tokat Gaziosmanpasa Univ, Fac Med, Dept Urol, Tokat, Turkey.
C3 Tokat Gaziosmanpasa University; Tokat Gaziosmanpasa University; Tokat
   Gaziosmanpasa University
RP Tasliyurt, T (corresponding author), Tokat Gaziosmanpasa Univ, Fac Med, Dept Internal Med, Tokat, Turkey.
EM turtasliyurt@hotmail.com
RI demir, ayse kevser/CAG-1952-2022; bilir, yeliz/GPG-1602-2022; UZUN,
   SUHEYLA/HKE-8748-2023
OI HAKAN, SIVGIN/0000-0001-5008-6576; bilir, yeliz/0000-0003-2217-4741;
   UZUN, SUHEYLA/0000-0003-3570-5361
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NR 35
TC 25
Z9 27
U1 0
U2 8
PU VERDUCI PUBLISHER
PI ROME
PA VIA GREGORIO VII, ROME, 186-00165, ITALY
SN 1128-3602
J9 EUR REV MED PHARMACO
JI Eur. Rev. Med. Pharmacol. Sci.
PD FEB
PY 2014
VL 18
IS 4
BP 581
EP 586
PG 6
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA AP3IA
UT WOS:000341967600020
PM 24610625
DA 2025-06-11
ER

PT J
AU De Pergola, G
   Cortese, F
   Termine, G
   Meliota, G
   Carbonara, R
   Masiello, M
   Cortese, AM
   Silvestris, F
   Caccavo, D
   Ciccone, MM
AF De Pergola, Giovanni
   Cortese, Francesca
   Termine, Gaetano
   Meliota, Giovanni
   Carbonara, Rossella
   Masiello, Michele
   Cortese, Anna M.
   Silvestris, Francesco
   Caccavo, Domenico
   Ciccone, Marco Matteo
TI Uric Acid, Metabolic Syndrome and Atherosclerosis: The Chicken or the
   Egg, Which Comes First?
SO ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS
LA English
DT Article
DE Uric acid; metabolic syndrome; carotid intima media thickness;
   atherosclerosis; cardiovascular disease; HDL
ID INTIMA-MEDIA THICKNESS; CAROTID-ARTERY INTIMA; C-REACTIVE PROTEIN;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; HEPATIC STEATOSIS; RISK-FACTORS;
   HYPERTENSION; DISEASE; OBESITY
AB Background: A great debate in literature exists nowadays on the role of uric acid as a marker of cardiovascular and metabolic organ damage or a risk factor for cardiovascular and metabolic disease.
   Methods: The study aimed to determine the relationship among serum uric acid and metabolic syndrome and atherosclerosis, by means of carotid intima media-thickness, in a cohort of 811 otherwise healthy overweight/obese subjects, without overt atherosclerosis not using any kind of drug.
   Results: Uric acid levels were positively related to male gender, waist circumference, BMI, systolic and diastolic pressure levels, fasting insulin, fasting glucose, HOMA-IR, triglycerides, total cholesterol, LDL cholesterol, the presence of metabolic syndrome and the number of the components of metabolic syndrome and negatively related to HDL cholesterol levels. No correlation was found between uric acid and carotid intima media thickness. At the multiple regression analysis, only waist circumference and triglycerides (positively) and HDL-cholesterol (negatively) maintained an independent association with uric acid as dependent variable, while age, female gender and uric acid showed a significant independent association with metabolic syndrome as dependent variable. Moreover, the analysis of the odd ratios showed that the risk of developing metabolic syndrome was consistent with uric acid levels ranging from 3 mg/dl to 8 mg/dl.
   Conclusion: The presence of metabolic syndrome does not seem to provide hyperuricemia. By contrast, higher serum uric acid level may predict the risk of metabolic syndrome. Moreover, our results suggest that uric acid cannot be considered a risk factor for early atherosclerosis, at least when assessed using carotid ultrasound.
C1 [De Pergola, Giovanni; Termine, Gaetano; Meliota, Giovanni; Masiello, Michele; Caccavo, Domenico] Univ Bari, Sch Med, Dept Internal Med & Clin Oncol, Clin Nutr Unit,Med Oncol, Piazza Giulio Cesare 11, I-70124 Bari, Italy.
   [Cortese, Francesca; Carbonara, Rossella; Ciccone, Marco Matteo] Univ Bari, Cardiovasc Dis Sect, Dept Organ Trasplantat, Bari, Italy.
   [Cortese, Anna M.] IRCCS Fdn Osped San Camillo, Dept Cerebrovasc Dis, Venice Lido, Italy.
   [Silvestris, Francesco] Univ Bari, Sch Med, Dept Internal Med & Clin Oncol, Med Oncol, Piazza Giulio Cesare 11, I-70124 Bari, Italy.
C3 Universita degli Studi di Bari Aldo Moro; Universita degli Studi di Bari
   Aldo Moro; IRCCS Ospedale San Camillo; Universita degli Studi di Bari
   Aldo Moro
RP Cortese, F (corresponding author), Univ Bari, Cardiovasc Dis Sect, Dept Organ Trasplantat, Bari, Italy.
EM francescacortese@hotmail.it
RI Meliota, Giovanni/LRT-4180-2024; Cortese, Francesca/P-6306-2019;
   Ciccone, Marco/C-5271-2013; De Pergola, Giovanni/AAL-9999-2020; Cortese,
   Anna Maria/J-5734-2018; carbonara, rosa/AHI-1972-2022; Cortese,
   Francesca/R-8978-2017
OI Meliota, Giovanni/0000-0002-9924-4915; Cortese, Anna
   Maria/0000-0002-3015-0902; carbonara, rosa/0000-0003-2274-170X; Cortese,
   Francesca/0000-0002-6899-3366
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NR 52
TC 20
Z9 20
U1 0
U2 12
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1871-5303
EI 2212-3873
J9 ENDOCR METAB IMMUNE
JI Endocr. Metab. Immune Disord.-Drug Targets
PY 2018
VL 18
IS 3
BP 251
EP 259
DI 10.2174/1871530318666180212101548
PG 9
WC Endocrinology & Metabolism; Immunology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Immunology; Pharmacology & Pharmacy
GA GB5GP
UT WOS:000429092600009
PM 29437024
DA 2025-06-11
ER

PT J
AU Bjelica, B
   Wohnrade, C
   Osmanovic, A
   Schreiber-Katz, O
   Schuppner, R
   Greten, S
   Petri, S
AF Bjelica, Bogdan
   Wohnrade, Camilla
   Osmanovic, Alma
   Schreiber-Katz, Olivia
   Schuppner, Ramona
   Greten, Stephan
   Petri, Susanne
TI Metabolic syndrome is common in adults with 5q-spinal muscular atrophy
   and impacts quality of life and fatigue
SO MUSCLE & NERVE
LA English
DT Article
DE central obesity; depression; dyslipidemia; fatigue; metabolic syndrome;
   quality of life; spinal muscular atrophy
ID INTIMA-MEDIA THICKNESS; PREVALENCE; RISK; POPULATION; CHILDREN; STROKE;
   SCALE
AB Introduction/AimsSpinal muscular atrophy (SMA) is a multisystem disorder. We assessed metabolic syndrome (MetS) prevalence in adults with SMA and its association with motor function, quality of life (QoL), fatigue, and depression.MethodsMetS was diagnosed using 2009 consensus criteria. Hammersmith Functional Motor Scale Expanded (HFMSE), Revised Upper Limb Module (RULM), Fatigue Severity Scale (FSS), Beck Depression Inventory (BDI), and 36-Item Short Form Health Survey (SF-36) were recorded and correlations between muscle function, depression, fatigue, QoL, and MetS were analyzed.ResultsWe included 36 individuals (18 males; mean age: 38.7 +/- 14.6 years). MetS was present in 25.0%. The most common component of MetS was central obesity (69.7%). Nearly half of the SMA individuals exhibited at least one abnormal lipid level result. Individuals with MetS more frequently were SMA type 3 (77.8% vs. 37.0%, p = .02) and had higher levels of fatigue (48.4 +/- 6.7 vs. 39.5 +/- 11.6, p = .03) than those without MetS. No associations of the presence of MetS with ambulatory status or HFMSE/RULM scores were observed. SMA individuals with MetS scored significantly lower in mental and social domains of QoL and total SF-36 score (p = .04). We observed weak to moderate correlations between the presence of MetS and SMA type, presence of comorbidities, QoL, and fatigue.DiscussionThe frequency of MetS was modestly higher among adults with SMA than in the general population, particularly in SMA type 3. MetS was associated with reduced QoL and increased fatigue. Larger studies are needed to fully understand the significance of MetS in adults with SMA.
C1 [Bjelica, Bogdan; Wohnrade, Camilla; Osmanovic, Alma; Schreiber-Katz, Olivia; Schuppner, Ramona; Greten, Stephan; Petri, Susanne] Hannover Med Sch, Dept Neurol, 1 Carl Neuberg Str, D-30625 Hannover, Germany.
   [Osmanovic, Alma] Univ Hosp Essen, Essen Ctr Rare Dis EZSE, Essen, Germany.
C3 Hannover Medical School; University of Duisburg Essen
RP Bjelica, B (corresponding author), Hannover Med Sch, Dept Neurol, 1 Carl Neuberg Str, D-30625 Hannover, Germany.
EM bjelica.bogdan@mh-hannover.de
RI Bjelica, Bogdan/GYU-0047-2022; Petri, Susanne/AID-7665-2022
OI Bjelica, Bogdan/0000-0002-1783-703X
FU Projekt DEAL
FX Open Access funding enabled and organized by Projekt DEAL.
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NR 39
TC 0
Z9 0
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0148-639X
EI 1097-4598
J9 MUSCLE NERVE
JI Muscle Nerve
PD AUG
PY 2024
VL 70
IS 2
BP 257
EP 264
DI 10.1002/mus.28183
EA JUN 2024
PG 8
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA XN1R1
UT WOS:001246013500001
PM 38872508
DA 2025-06-11
ER

PT J
AU Fischer, CW
   Liebenberg, N
   Elfving, B
   Lund, S
   Wegener, G
AF Fischer, Christina W.
   Liebenberg, Nico
   Elfving, Betina
   Lund, Sten
   Wegener, Gregers
TI Isolation-induced behavioural changes in a genetic animal model of
   depression
SO BEHAVIOURAL BRAIN RESEARCH
LA English
DT Article
DE Depression; Social isolation; Stress; Metabolism; Animal behaviour
ID SENSITIVE LINE RATS; SOCIAL-ISOLATION; ENVIRONMENTAL ENRICHMENT;
   ANTIDEPRESSANT TREATMENT; RECOGNITION MEMORY; METABOLIC SYNDROME;
   NUCLEUS-ACCUMBENS; BODY-WEIGHT; BRAIN; HIPPOCAMPUS
AB Depression is a heterogeneous disorder displaying a range of symptoms including feelings of despair and social withdrawal. Social isolation may complicate the progression of depression and have effects on both behaviour and physiology. The aim of this study was to investigate the effects of social isolation on behavioural and metabolic parameters in a genetic rat model of depression, the Flinders Sensitive and Resistant Line (FSL/FRL) rats. Rats were housed either individually (social isolation) or pair-housed for 5 weeks, and subjected to behavioural testing and metabolic evaluation. We found that social isolation erased the characteristic difference in depressive-like behaviour, measured as immobility in the forced swim test, between the FSL and FRL rats. Social isolation affected both strains equally in impairing object recognition memory, while leading to an increased explorative behaviour in the elevated plus maze test. Surprisingly, single-housed FRL rats showed an increased food intake compared to pair-housed FRL rats, whereas no difference in food intake or body weight was evident in FSL rats. Our results indicate that social isolation for 5 weeks causes behavioural alterations, independent of strain. As the changes in appetite were only observed in the FRL rats, this may suggest that this strain responds to the stress of isolation by a change in feeding behaviour. (C) 2012 Elsevier B.V. All rights reserved.
C1 [Fischer, Christina W.; Liebenberg, Nico; Elfving, Betina; Wegener, Gregers] Aarhus Univ Hosp, Ctr Psychiat Res, DK-8240 Risskov, Denmark.
   [Lund, Sten] Aarhus Univ Hosp, Med Res Lab, DK-8240 Risskov, Denmark.
   [Lund, Sten] Aarhus Univ Hosp, Med Dept Endocrinol & Diabet M, DK-8240 Risskov, Denmark.
   [Wegener, Gregers] North West Univ, Sch Pharm Pharmacol, Unit Drug Res & Dev, Potchefstroom, South Africa.
C3 Aarhus University; Aarhus University; Aarhus University; North West
   University - South Africa
RP Wegener, G (corresponding author), Aarhus Univ Hosp, Ctr Psychiat Res, Skovagervej 2, DK-8240 Risskov, Denmark.
EM christinawfischer@gmail.com; wegener@dadlnet.dk
RI Elfving, Betina/H-2814-2019; Wegener, Gregers/A-1019-2011
OI Elfving, Betina/0000-0001-6939-5088; Wegener,
   Gregers/0000-0002-0081-0068; Liebenberg, Nico/0000-0001-9655-8911; Lund,
   Sten/0000-0002-3805-6267
FU Augustinus Foundation; Aase og Ejnar Danielsens Fond; foundation for
   research in County Midtjylland; Aarhus University
FX The study was supported by the Augustinus Foundation, Aase og Ejnar
   Danielsens Fond, the foundation for research in County Midtjylland, and
   Aarhus University. The technical assistance supplied by Pia Hogh
   Plougmann is gratefully acknowledged.
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NR 48
TC 23
Z9 24
U1 0
U2 6
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0166-4328
EI 1872-7549
J9 BEHAV BRAIN RES
JI Behav. Brain Res.
PD APR 21
PY 2012
VL 230
IS 1
BP 85
EP 91
DI 10.1016/j.bbr.2012.01.050
PG 7
WC Behavioral Sciences; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Behavioral Sciences; Neurosciences & Neurology
GA 973SJ
UT WOS:000306379800010
PM 22321459
DA 2025-06-11
ER

PT J
AU Oxenkrug, G
   Summergrad, P
AF Oxenkrug, Gregory
   Summergrad, Paul
TI Benserazide, an Inhibitor of Peripheral Kynurenine Metabolism,
   Attenuates Olanzapine-Induced Weight Gain, Insulin Resistance, and
   Dyslipidemia in C57Bl/6j Mice
SO MOLECULAR NEUROBIOLOGY
LA English
DT Article
DE Benserazide; Olanzapine; Obesity; Insulin resistance; Kynurenic acid;
   Anthranilic acid; Metabolic syndrome
ID TRYPTOPHAN-KYNURENINE; DYSREGULATION; SCHIZOPHRENIA; HOMEOSTASIS;
   ACTIVATION; OBESITY; ACID
AB Schizophrenia (Sz) patients, especially treated with atypical antipsychotics, are at high risk of the development of metabolic syndrome that increases morbidity and mortality and impairs compliance with treatment. Mechanism of the high association of metabolic syndrome with the use of atypical antipsychotics is not clear. Literature and our data suggest that chronic inflammation- or stress-induced dysregulation of the peripheral down-stream kynurenine (Kyn) metabolism, shared by both Sz and metabolic syndrome, contributes to the development of metabolic syndrome in Sz patients treated with atypical antipsychotics. Correction of dysregulation of the peripheral down-stream metabolism of Kyn would prevent/treat metabolic syndrome. This is a pre-clinical trial of the effect of benserazide (BRZ), an inhibitor of the key enzymes of Kyn metabolism, on olanzapine-induced mouse model of metabolic syndrome. Olanzapine is one of the most effective atypical antipsychotics but has high potential to induce metabolic syndrome. Olanzapine (4 mg/kg, p.o) and/or BRZ (100 mg/day, p.o.) were administered to 6-week-old C57Bl/6 female mice, 5 days/week, for 10 weeks. The study was approved by the Tufts Medical Center Institutional Animal Care and Use Committee. BRZ attenuated olanzapine-induced excessive weight gain, impairment of glucose tolerance, and elevation of plasma cholesterol and triglycerides. Present results suggest that peripheral down-stream Kyn metabolism is a new target for prevention/treatment of olanzapine-induced metabolic syndrome. BRZ has a high translational potential as medication already approved for human use.
C1 [Oxenkrug, Gregory; Summergrad, Paul] Tufts Univ, Sch Med, Dept Psychiat, Psychiat & Inflammat Program,Tufts Med Ctr, Boston, MA 02111 USA.
C3 Tufts University; Tufts Medical Center
RP Oxenkrug, G (corresponding author), Tufts Univ, Sch Med, Dept Psychiat, Psychiat & Inflammat Program,Tufts Med Ctr, Boston, MA 02111 USA.
EM goxenkrug@tuftsmedicalcenter.org
RI Summergrad, Paul/AAI-1698-2021
OI Summergrad, Paul/0000-0001-9991-6761
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NR 30
TC 13
Z9 13
U1 0
U2 16
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0893-7648
EI 1559-1182
J9 MOL NEUROBIOL
JI Mol. Neurobiol.
PD JAN
PY 2020
VL 57
IS 1
SI SI
BP 135
EP 138
DI 10.1007/s12035-019-01763-x
PG 4
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA KV1HZ
UT WOS:000520176200013
PM 31515691
DA 2025-06-11
ER

PT J
AU Esler, M
   Straznicky, N
   Eikelis, N
   Masuo, K
   Lambert, G
   Lambert, E
AF Esler, Murray
   Straznicky, Nora
   Eikelis, Nina
   Masuo, Kazuko
   Lambert, Gavin
   Lambert, Elisabeth
TI Mechanisms of sympathetic activation in obesity-related hypertension
SO HYPERTENSION
LA English
DT Review
ID OBSTRUCTIVE SLEEP-APNEA; BLOOD-PRESSURE ELEVATION; BODY-FAT
   DISTRIBUTION; INSULIN-RESISTANCE; METABOLIC SYNDROME; SKELETAL-MUSCLE;
   NERVOUS-SYSTEM; WEIGHT-GAIN; MENTAL STRESS; GLUCOSE-INTOLERANCE
C1 Baker Heart Res Inst, Melbourne, Vic 8008, Australia.
   Baker Heart Res Inst, Human Neurotransmitter Lab, Melbourne, Vic, Australia.
C3 Baker Heart and Diabetes Institute; Baker Heart and Diabetes Institute
RP Esler, M (corresponding author), Baker Heart Res Inst, POB 6492 St Kilda Rd Cent, Melbourne, Vic 8008, Australia.
EM murray.esler@baker.edu.au
RI Lambert, Gavin/E-7384-2010; Lambert, Elisabeth/E-7463-2010; Straznicky,
   Nora/E-7484-2010
OI Lambert, Gavin/0000-0003-0315-645X; Lambert,
   Elisabeth/0000-0002-2232-9048
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NR 104
TC 330
Z9 358
U1 1
U2 16
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0194-911X
EI 1524-4563
J9 HYPERTENSION
JI Hypertension
PD NOV
PY 2006
VL 48
IS 5
BP 787
EP 796
DI 10.1161/01.HYP.0000242642.42177.49
PG 10
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 127PE
UT WOS:000243598000001
PM 17000932
OA Bronze
DA 2025-06-11
ER

PT J
AU Llopis, S
   Rodrigo, MJ
   González, N
   Genovés, S
   Zacarías, L
   Ramón, D
   Martorell, P
AF Llopis, Silvia
   Jesus Rodrigo, Maria
   Gonzalez, Nuria
   Genoves, Salvador
   Zacarias, Lorenzo
   Ramon, Daniel
   Martorell, Patricia
TI -Cryptoxanthin Reduces Body Fat and Increases Oxidative Stress Response
   in Caenorhabditis elegans Model
SO NUTRIENTS
LA English
DT Article
DE -Cryptoxanthin; carotenoids; Caenorhabditis elegans; fat reduction;
   oxidative stress; transcriptomic analysis; metabolic syndrome; aging
ID BETA-CRYPTOXANTHIN; SERUM CAROTENOIDS; INSULIN-RESISTANCE; METABOLIC
   SYNDROME; ANTIOXIDANT ACTIVITY; ALPHA-CAROTENE; ORANGE FRUIT; VISCERAL
   FAT; C. ELEGANS; MASS INDEX
AB -Cryptoxanthin (BCX) is a major dietary pro-vitamin A carotenoid, found mainly in fruits and vegetables. Several studies showed the beneficial effects of BCX on different aspects of human health. In spite of the evidence, the molecular mechanisms of action of BCX need to be further investigated. The Caenorhabditis elegans model was used to analyze in vivo the activity of BCX on fat reduction and protection to oxidative stress. Dose-response assays provided evidence of the efficacy of BCX at very low dose (0.025 mu g/mL) (p < 0.001) on these processes. Moreover, a comparative analysis with other carotenoids, such as lycopene and -carotene, showed a stronger effect of BCX. Furthermore, a transcriptomic analysis of wild-type nematodes supplemented with BCX revealed upregulation of the energy metabolism, response to stress, and protein homeostasis as the main metabolic targets of this xanthophyll. Collectively, this study provides new in vivo evidence of the potential therapeutic use of BCX in the prevention of diseases related to metabolic syndrome and aging.
C1 [Llopis, Silvia; Gonzalez, Nuria; Genoves, Salvador; Ramon, Daniel; Martorell, Patricia] Biopolis SL Archer Daniels Midland, Food Biotechnol Dept, Cell Biol Lab, C Catedratico Agustin Escardino Benlloch 9, Valencia 46890, Spain.
   [Jesus Rodrigo, Maria; Zacarias, Lorenzo] CSIC, Inst Agroquim & Tecnol Alimentos, Food Biotechnol Dept, C Catedratico Agustin Escardino 7, Valencia 46890, Spain.
C3 Consejo Superior de Investigaciones Cientificas (CSIC); Instituto de
   Agroquimica y Tecnologia de los Alimentos (IATA)
RP Martorell, P (corresponding author), Biopolis SL Archer Daniels Midland, Food Biotechnol Dept, Cell Biol Lab, C Catedratico Agustin Escardino Benlloch 9, Valencia 46890, Spain.
EM silvia.llopis@adm.com; mjrodrigo@iata.csic.es; nuria.gonzalez@adm.com;
   Salvador.Genoves@adm.com; lzacarias@iata.csic.es;
   Daniel.RamonVidal@adm.com; patricia.martorell@adm.com
RI Martorell, Patricia/ABC-8717-2021; Rodrigo, Maria Jesus/H-7720-2012;
   Zacarias, Lorenzo/W-2510-2018
OI Ramon Vidal, Daniel/0000-0002-0977-4745; Rodrigo, Maria
   Jesus/0000-0003-2668-0684; Zacarias, Lorenzo/0000-0003-3982-8860
FU Spanish Ministry of Economy and Competitiveness (MINECO), Consolider
   Fun-C-Food [CSD 2007-00063, AGL2015-70218]; Spanish MINECO
   [BIO2015-71703-REDT, BIO2017-90877-REDT]; European Carotenoid Network
   (EuroCaroten) - European Commission COST action [CA15136]
FX This study has been funded by the Spanish Ministry of Economy and
   Competitiveness (MINECO), Consolider Fun-C-Food (CSD 2007-00063
   project), and AGL2015-70218. M.J.R. and L.Z. belong to the Spanish
   Carotenoid Network (CaRed) funded by the Spanish MINECO grant
   BIO2015-71703-REDT and BIO2017-90877-REDT, and the European Carotenoid
   Network (EuroCaroten) funded by the European Commission COST action
   CA15136. We thank to the UCIM at University of Valencia for performing
   the DNA arrays.
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NR 79
TC 21
Z9 21
U1 4
U2 14
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD FEB
PY 2019
VL 11
IS 2
AR 232
DI 10.3390/nu11020232
PG 20
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA HO3NH
UT WOS:000460829700023
PM 30678209
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Molina-Leyva, A
   Caparros-DelMoral, I
   Ruiz-Carrascosa, JC
   Naranjo-Sintes, R
   Jimenez-Moleon, JJ
AF Molina-Leyva, A.
   Caparros-delMoral, I.
   Ruiz-Carrascosa, J. C.
   Naranjo-Sintes, R.
   Jimenez-Moleon, J. J.
TI Elevated prevalence of Type D (distressed) personality in moderate to
   severe psoriasis is associated with mood status and quality of life
   impairment: a comparative pilot study
SO JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
LA English
DT Article
ID HEALTH SURVEY SF-36; MYOCARDIAL-INFARCTION; NEGATIVE AFFECTIVITY;
   METABOLIC SYNDROME; SOCIAL INHIBITION; DISABILITY-INDEX; SPANISH
   VERSION; MENTAL-HEALTH; IMPACT; RISK
AB BackgroundPsoriasis may imply a remarkable psychological impairment, which can influence patient's personality. The Type D personality is defined by the combination of social inhibition and negative affectivity. Furthermore, Type D personality has been associated with impaired health-related quality of life (HRQOL) and increased cardiovascular risk, both facts being associated with moderate to severe psoriasis.
   ObjectivesTo explore the prevalence of Type D personality in moderate to severe psoriasis patients; To analyse the relationship between Type D personality and the most common physical and psychological comorbidities in moderate to severe psoriasis and To explore the impact of Type D personality on HRQOL.
   MethodsA prospective comparative study matched to age and sex. Eighty patients with moderate to severe psoriasis and 80 healthy volunteers were included in the study. The participants completed the DS14 test, the Massachusetts General Hospital-Sexual Functioning Questionnaire, the Hospital Anxiety and Depression Scale, the SF-36 and the Psoriasis Disability Index.
   ResultsThe prevalence of Type D personality was higher in patients with moderate to severe psoriasis as compared to healthy volunteers: 38.7% vs. 23.7%, P<0.001. Psoriasis patients with Type D personality had a 3.2-fold risk of anxiety when compared to patients without Type D personality; odds ratio 3.2 (1.3-8.83 P=0.01). Type D personality was significantly associated with an impaired general, sexual and psoriasis-related HRQOL (P<0.01).
   ConclusionBecause Type D personality could represent a frequent type of personality among individuals with moderate to severe psoriasis, it could serve as a marker' of more psychologically vulnerable patients, probably related to dysfunctional coping strategies. The Type D personality could represent a profile more frequently encountered among patients with psoriasis, and might therefore help identify subjects physiologically more vulnerable to disease, most likely due to inadequate adaptation mechanisms.
C1 [Molina-Leyva, A.] Hosp Torrecardenas, Dept Dermatol, Almeria, Spain.
   [Caparros-delMoral, I.] Hosp Huercal Overa, Unit Psychiat, Almeria, Spain.
   [Ruiz-Carrascosa, J. C.; Naranjo-Sintes, R.] Univ Hosp, Dept Dermatol, Granada, Spain.
   [Jimenez-Moleon, J. J.] CIBERESP, Granada, Spain.
   [Jimenez-Moleon, J. J.] Univ Granada, Hosp Univ Granada, Inst Invest Biosanit Ibs, Dept Med Preventiva & Salud Publ, Granada, Spain.
C3 Hospital Torrecardenas; CIBER - Centro de Investigacion Biomedica en
   Red; CIBERESP; University of Granada; Instituto de Investigacion
   Biosanitaria IBS Granada
RP Molina-Leyva, A (corresponding author), Hosp Torrecardenas, Dept Dermatol, Almeria, Spain.
EM alejandromolinaleyva@gmail.com
RI Jimenez-Moleon, Jose J./O-2519-2016; Molina-Leyva, Alejandro/M-1213-2014
OI Jimenez-Moleon, Jose J./0000-0001-7917-6145; Molina-Leyva,
   Alejandro/0000-0001-6882-2113
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NR 45
TC 26
Z9 26
U1 0
U2 17
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0926-9959
EI 1468-3083
J9 J EUR ACAD DERMATOL
JI J. Eur. Acad. Dermatol. Venereol.
PD SEP
PY 2015
VL 29
IS 9
BP 1710
EP 1717
DI 10.1111/jdv.12960
PG 8
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology
GA CP9LL
UT WOS:000360215700005
PM 25623927
DA 2025-06-11
ER

PT J
AU Ren, SY
   Xu, XH
AF Ren, Sidney Y.
   Xu, Xihui
TI Role of autophagy in metabolic syndrome-associated heart disease
SO BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
LA English
DT Review
DE Autophagy; Heart; Metabolic syndrome; High fat diet; Obesity
ID INDUCED CARDIAC-HYPERTROPHY; DIET-INDUCED OBESITY; 3RD NATIONAL-HEALTH;
   INSULIN-RESISTANCE; CONTRACTILE DYSFUNCTION; CARDIOVASCULAR-DISEASE;
   MOLECULAR-MECHANISMS; MYOCARDIAL-ISCHEMIA; DIASTOLIC FUNCTION;
   PROVISIONAL REPORT
AB Metabolic syndrome is a constellation of multiple metabolic risk factors including abdominal obesity, glucose intolerance, insulin resistance, dyslipidemia and hypertension. Over the past decades, the prevalence of metabolic syndrome has increased dramatically, imposing a devastating, pandemic health threat More importantly, individuals with metabolic syndrome are at an increased risk of diabetes mellitus and overall cardiovascular diseases. One of the common comorbidities of metabolic syndrome is heart anomalies leading to the loss of cardiomyocytes, cardiac dysfunction and ultimately heart failure. Up-to-date, a plethora of cell signaling pathways have been postulated for the pathogenesis of cardiac complications in obesity including lipotoxicity, inflammation, oxidative stress, apoptosis and sympathetic overactivation although the precise mechanism of action underscoring obesity-associated heart dysfunction remains elusive. Recent evidence has indicated a potential role of protein quality control in components of metabolic syndrome. Within the protein quality control system, the autophagy-lysosome pathway is an evolutionarily conserved pathway responsible for bulk degradation of large intracellular organelles and protein aggregates. Autophagy has been demonstrated to play an indispensible role in the maintenance of cardiac geometry and function under both physiological and pathological conditions. Accumulating studies have demonstrated that autophagy plays a pivotal role in the etiology of cardiac anomalies under obesity and metabolic syndrome. In this minireview, we will discuss on how autophagy is involved in the regulation of cardiac function in obesity and metabolic syndrome. This article is part of a Special Issue entitled: Autophagy and protein quality control in cardiometabolic diseases. (C) 2014 Elsevier B.V. All rights reserved.
C1 [Ren, Sidney Y.; Xu, Xihui] Univ Wyoming, Coll Hlth Sci, Sch Pharm, Ctr Cardiovasc Res & Alternat Med, Laramie, WY 82071 USA.
C3 University of Wyoming
RP Xu, XH (corresponding author), Univ Wyoming, Coll Hlth Sci, Sch Pharm, Ctr Cardiovasc Res & Alternat Med, Laramie, WY 82071 USA.
EM xxu6@uwyo.edu
RI Xu, Xihui/C-2017-2014
FU Wyoming IDeA Network for Biomedical Research Excellence (INBRE) [P20
   GM103432]; Wyoming Experimental Program to Stimulate Competitive
   Research (EPSCoR) (NIH/NCRR) [5P20RR016474]; Wyoming Experimental
   Program to Stimulate Competitive Research (EPSCoR) (NIH/NIGMS)
   [8P20GM103432]
FX The work from the authors' laboratory was supported in part by a
   research project from Wyoming IDeA Network for Biomedical Research
   Excellence (INBRE, P20 GM103432) to XX. SYR was supported by a
   fellowship from the Wyoming Experimental Program to Stimulate
   Competitive Research (EPSCoR) (NIH/NCRR 5P20RR016474 and NIH/NIGMS
   8P20GM103432).
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NR 56
TC 56
Z9 61
U1 0
U2 28
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0925-4439
EI 1879-260X
J9 BBA-MOL BASIS DIS
JI Biochim. Biophys. Acta-Mol. Basis Dis.
PD FEB
PY 2015
VL 1852
IS 2
SI SI
BP 225
EP 231
DI 10.1016/j.bbadis.2014.04.029
PG 7
WC Biochemistry & Molecular Biology; Biophysics; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Cell Biology
GA CA5QR
UT WOS:000348963400006
PM 24810277
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Kovanen, L
   Donner, K
   Partonen, T
AF Kovanen, Leena
   Donner, Kati
   Partonen, Timo
TI SIRT1 Polymorphisms Associate with Seasonal Weight Variation,
   Depressive Disorders, and Diastolic Blood Pressure in the General
   Population
SO PLOS ONE
LA English
DT Article
ID METABOLIC SYNDROME; MONOAMINE-OXIDASE
AB SIRT1 polymorphisms have previously been associated with depressive and anxiety disorders. We aimed at confirming these earlier findings and extending the analyses to seasonal variations in mood and behavior. Three tag single-nucleotide polymorphisms (SNPs) were selected to capture the common variation in the SIRT1 gene. 5910 individuals (with blood sample, diagnostic interview, self-report of on seasonal changes in mood and behavior) were selected from a representative Finnish nationwide population-based sample. Logistic and linear regression models were used to analyze the associations between the SNPs and depressive and anxiety disorders, metabolic syndrome (EGIR criteria) and its components, and health examination measurements, Homeostasis Model Assessments, and diagnoses of type 2 and type 1 diabetes. SIRT1 rs2273773 showed evidence of association with seasonal variation in weight (C-allele, OR = 0.85, 95% CI = 0.76-0.95, p = 0.005). In addition, our study gave further support for the association of SIRT1 gene with depressive disorders (rs3758391) and diastolic blood pressure (rs2273773).
C1 [Kovanen, Leena; Partonen, Timo] Natl Inst Hlth & Welf THL, Dept Hlth Mental Hlth Unit, Helsinki, Finland.
   [Donner, Kati] Univ Helsinki, Inst Mol Med Finland, Helsinki, Finland.
C3 Finland National Institute for Health & Welfare; University of Helsinki
RP Kovanen, L (corresponding author), Natl Inst Hlth & Welf THL, Dept Hlth Mental Hlth Unit, Helsinki, Finland.
EM leena.kovanen@thl.fi
RI Donner, Kati/HJI-0750-2023; Partonen, Timo/G-1105-2012
OI Donner, Kati/0000-0001-9190-4336; Kovanen, Leena/0000-0002-3552-124X
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NR 27
TC 28
Z9 32
U1 0
U2 10
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD OCT 28
PY 2015
VL 10
IS 10
AR e0141001
DI 10.1371/journal.pone.0141001
PG 10
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA CV0DL
UT WOS:000363918100045
PM 26509718
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Angelico, F
   Del Ben, M
   Francioso, S
   Hurtova, M
   Battista, S
   Palmieri, GP
   Tisone, G
   Angelico, M
AF Angelico, F
   Del Ben, M
   Francioso, S
   Hurtova, M
   Battista, S
   Palmieri, GP
   Tisone, G
   Angelico, M
TI Recurrence of insulin resistant metabolic syndrome following liver
   transplantation
SO EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
LA English
DT Article
DE metabolic syndrome; cardiovascular risk factors; liver transplantation;
   non-alcoholic steatohepatitis; cryptogenic cirrhosis
ID NONALCOHOLIC STEATOHEPATITIS; CRYPTOGENIC CIRRHOSIS
AB Insulin resistant metabolic syndrome is a major clinical disorder including hyperlipidaemia, hypertension, impaired glucose tolerance and/or type 2 diabetes and central obesity, which are well established cardiovascular risk factors. We report the case of a 61-year-old woman who developed severe hypercholesterolaemia and hypertriglyceridaemia after liver transplantation. In her forties she had hypertension, mixed hyperlipidaemia, mild hyperglycaemia and moderate abdominal obesity, suggesting the presence of the metabolic syndrome. She had liver enzyme elevation and severe steatosis and hepatomegaly at ultrasonography. At age 52, cryptogenic liver cirrhosis was diagnosed and rapidly progressing liver failure developed. In 1992 she underwent liver transplantation. Seven years after transplant the patient had abdominal obesity, high blood pressure, marked hypercholesterolaemia, hypertriglyceridaemia and moderate elevation of alanine aminotransferase. She also had impaired glucose tolerance and markedly increased basal and post-glucose load plasma insulin levels. Steato-hepatitis was demonstrated by serial liver biopsies. This is the first case that reports the recurrence of the metabolic syndrome following liver transplantation. We postulate that metabolic syndrome may have promoted fatty liver and subsequent progression to end stage liver disease. We also stress the need for careful management of the metabolic syndrome in order to decrease the long-term risk for cardiovascular disease. (C) 2003 Lippincott Williams Wilkins.
C1 Univ Roma La Sapienza, Dept Clin & Appl Med Therapy, Rome, Italy.
   Univ Roma La Sapienza, Dept Expt Med & Clin Pathol, Rome, Italy.
   Univ Roma Tor Vergata, Dept Pathol, Rome, Italy.
   Univ Roma Tor Vergata, Dept Surg, Rome, Italy.
   Univ Roma Tor Vergata, Dept Gastroenterol, Rome, Italy.
C3 Sapienza University Rome; Sapienza University Rome; University of Rome
   Tor Vergata; University of Rome Tor Vergata; University of Rome Tor
   Vergata
RP Via Antonio Nibby B, I-00161 Rome, Italy.
EM Francesco.angelico@uniromal.it
RI Maurano, Francesco/H-6487-2013; Angelico, Francesco/AAB-6585-2020
OI Battista, Serena/0000-0002-8191-0131; ANGELICO,
   Mario/0000-0003-2883-9206
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NR 11
TC 12
Z9 12
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0954-691X
EI 1473-5687
J9 EUR J GASTROEN HEPAT
JI Eur. J. Gastroenterol. Hepatol.
PD JAN
PY 2003
VL 15
IS 1
BP 99
EP 102
DI 10.1097/00042737-200301000-00018
PG 4
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 642HJ
UT WOS:000180797900018
PM 12544703
DA 2025-06-11
ER

PT J
AU Lu, ZY
   Liu, SF
   Lopes-Virella, MF
   Wang, ZW
AF Lu, Zhongyang
   Liu, Shufeng
   Lopes-Virella, Maria F.
   Wang, Zhewu
TI LPS and palmitic acid Co-upregulate microglia activation and
   neuroinflammatory response
SO COMPREHENSIVE PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE Lipopolysaccharides; Palmitic acid; Sphingolipid; Microglia;
   Neuroinflammation
ID HYPOTHALAMIC INFLAMMATION; ALZHEIMERS-DISEASE; FATTY-ACIDS; MECHANISMS;
   BRAIN; LIPOPOLYSACCHARIDE; STRESS; ALPHA; NEUROTOXICITY; DEPRESSION
AB Growing evidence indicates that disturbances in the inflammatory response system can have deleterious effects on neuronal function and mental health. While the correlation between elevated peripheral inflammatory markers and psychiatric disorders are well documented, the exact molecular and neuronal mechanism underlying the connection between activated inflammation and neuropsychiatric behaviour remain elusive. Microglia activation is the key interface between neuro-inflammation and manifestation of psychiatric symptoms. Microglia are immunocompetent cells in the central nervous system (CNS) which are primarily involved in the response to inflammatory stimulation and are widely used to study neuroinflammation and test anti-inflammatory chemicals. In the brain, activated microglia play very important roles during neuroinflammation and neurodegeneration. Both stress-related disorders such as Depression and PTSD, and medical conditions such as metabolic syndrome (Mets) and type 2 diabetes (TD2) are associated with increased levels of both saturated fatty acids (SFAs) and lipopolysaccharide (LPS) in circulation. This work was aimed at determining whether SFA interacts with LPS to activate microglia, thus up-regulating neuroinflammatory processes and, if so which pathways were involved in this process. Our results showed that low-dose LPS and palmitic acid (PA) robustly stimulated the expression of proinflammatory cytokines, and the combination of PA and LPS further upregulated proinflammatory cytokines through MAPK, NF kappa B and AP-1 signaling pathways in the HMC3-human microglial cell line. In addition, PA stimulated ceramide production via de novo synthesis and sphingomyelin hydrolysis, and the combination of LPS and PA further increased ceramide production. HMC3 co-cultured with macrophage and lymphocyte enhanced LPS and PA induced-inflammatory response more than that in HMC3 alone. These results indicate that LPS in-teracts with PA to activated microglia; induced neuroinflammatory responses, upregulate proinflammatory cytokine expression via MAPK, NF kappa B, and AP-1 signaling pathways, and induced sphingolipid metabolism in HMC3. These observations suggest that inhibiting microglia activation and reducing LPS and PA-induced in-flammatory response may be useful in the treatment of neuronal inflammatory diseases.
C1 [Lu, Zhongyang; Lopes-Virella, Maria F.] Med Univ South Carolina, Dept Med, Div Endocrinol Diabet & Med Genet, Charleston, SC 29425 USA.
   [Liu, Shufeng; Lopes-Virella, Maria F.; Wang, Zhewu] Ralph H Johnson VA Med Ctr, Charleston, SC 29425 USA.
   [Liu, Shufeng; Wang, Zhewu] Med Univ South Carolina, Dept Psychiat, Charleston, SC 29425 USA.
C3 Medical University of South Carolina; US Department of Veterans Affairs;
   Veterans Health Administration (VHA); Ralph H Johnson VA Medical Center;
   Medical University of South Carolina
RP Lu, ZY (corresponding author), Med Univ South Carolina, Dept Med, Div Endocrinol Diabet & Med Genet, Charleston, SC 29425 USA.; Wang, ZW (corresponding author), Ralph H Johnson VA Med Ctr, Charleston, SC 29425 USA.
EM luz@musc.edu; wanzh@musc.edu
RI Li, Shao/GPX-5473-2022
OI Lu, Zhongyang/0000-0002-2182-7854; Wang, Zhewu/0000-0002-2549-0347
FU Clinical Sciences Research and Development Pro-gram of the Department of
   Veterans Affairs [I01CX000851]
FX We thank Dr. Rita Young for her initial design of this study. All work
   was supported by the Clinical Sciences Research and Development Pro-gram
   of the Department of Veterans Affairs (I01CX000851) (Zhewu Wang) .
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NR 50
TC 21
Z9 23
U1 3
U2 11
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2666-4976
J9 COMPR PSYCHONEUROEND
JI Compr. Psychoneuroendocrinol.
PD MAY
PY 2021
VL 6
AR 100048
DI 10.1016/j.cpnec.2021.100048
PG 8
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA X2YA0
UT WOS:001097149300008
PM 35757363
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Räikkönen, K
   Matthews, KA
   Sutton-Tyrrell, K
   Kuller, LH
AF Räikkönen, K
   Matthews, KA
   Sutton-Tyrrell, K
   Kuller, LH
TI Trait anger and the metabolic syndrome predict progression of carotid
   atherosclerosis in healthy middle-aged women
SO PSYCHOSOMATIC MEDICINE
LA English
DT Article
DE anger; carotid atherosclerosis; metabolic syndrome; women
ID CORONARY-HEART-DISEASE; PSYCHOLOGICAL RISK; PSYCHOSOCIAL FACTORS;
   INSULIN-RESISTANCE; WALL THICKNESS; HOSTILITY; MEN; STRESS
AB Objective: Hostility may predict coronary heart disease morbidity and mortality, as well as the metabolic syndrome. We tested to see if high levels of the attitudinal and emotional aspects of hostility lead to progression of carotid atherosclerosis in women and if the metabolic syndrome is a mediator of the association. Methods: Two hundred nine healthy women were followed during the perimenopausal and postmenopausal periods. Carotid artery ultrasound scans measured intima-media thickness (IMT) an average 7.4 (SD = 0.9, range 4.2-10.8) and 10.5 years (SD = 1. 1, range = 6.9-13.0) after baseline. Hostility was measured at baseline and at the first carotid scan with Spielberger Trait Anger (being angry frequently) and Anger In (suppressing angry feelings) scales, and the Cook-Medley Hostility Inventory (hostile, cynical attitudes toward others). Metabolic syndrome was measured at the study entry and through the second carotid scan. Results: Baseline Trait Anger scores predicted an increase in IMT across 3 years (p < .05) and predicted the risk for developing the metabolic syndrome (p < .05). The risk for developing the metabolic syndrome, in turn, predicted an increase in IMT across 3 years (p < .05). Anger suppression and cynical attitudes were not associated with progression of carotid atherosclerosis. Conclusion: Anger predicts progression of carotid atherosclerosis, and the metabolic syndrome may mediate this association. Women who experience angry feelings frequently may benefit from interventions aimed at reducing anger and reducing the metabolic syndrome components early in the natural history of atherosclerosis.
C1 Univ Pittsburgh, Dept Psychiat, Pittsburgh, PA 15213 USA.
   Univ Helsinki, Dept Psychol, Helsinki, Finland.
   Univ Pittsburgh, Dept Epidemiol, Pittsburgh, PA 15213 USA.
   Univ Pittsburgh, Dept Psychol, Pittsburgh, PA 15213 USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE); University
   of Pittsburgh; University of Helsinki; Pennsylvania Commonwealth System
   of Higher Education (PCSHE); University of Pittsburgh; Pennsylvania
   Commonwealth System of Higher Education (PCSHE); University of
   Pittsburgh
RP Univ Pittsburgh, Dept Psychiat, 3811 O Hara St, Pittsburgh, PA 15213 USA.
EM matthewska@upmc.edu
OI Raikkonen, Katri/0000-0003-3124-3470
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NR 36
TC 52
Z9 59
U1 0
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0033-3174
EI 1534-7796
J9 PSYCHOSOM MED
JI Psychosom. Med.
PD NOV-DEC
PY 2004
VL 66
IS 6
BP 903
EP 908
DI 10.1097/01.psy.0000143638.31297.11
PG 6
WC Psychiatry; Psychology; Psychology, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry; Psychology
GA 874JY
UT WOS:000225347900016
PM 15564356
DA 2025-06-11
ER

PT J
AU Ettaro, R
   Laudermilk, L
   Clark, SD
   Maitra, R
AF Ettaro, Robert
   Laudermilk, Lucas
   Clark, Stewart D.
   Maitra, Rangan
TI Behavioral assessment of rimonabant under acute and chronic conditions
SO BEHAVIOURAL BRAIN RESEARCH
LA English
DT Article
DE Cannabinoids; CB1; Rimonabant; Behavior; Depression; Chronic
ID CARDIOMETABOLIC RISK-FACTORS; ANXIETY-LIKE BEHAVIOR; CANNABINOID
   RECEPTOR; ENDOCANNABINOID SYSTEM; OBESITY; ANTAGONISTS; WEIGHT;
   INVOLVEMENT; INHIBITION; MECHANISMS
AB Cannabinoid subtype 1 receptor (CB1R) antagonists were originally developed as anti-obesity agents. Unfortunately, SR1417116A (rimonabant), the first marketed inverse agonist of CB1R, produced CNS-related adverse effects including depression and suicidal ideation, and thus it was withdrawn from the market. These effects of rimonabant became evident in patients following chronic dosing. Standard preclinical toxicity studies failed to detect these adverse effects. The goal of these studies was to perform an integrated battery of behavioral assays to better understand the behavioral effects of rimonabant following both acute and chronic administration. In the present study, acute dosing with rimonabant in rats significantly decreased food consumption; decreased measures of locomotor activity; increased scratching, grooming and wet-dog shakes; and increased defecation. Subsequently, animals were tested using a chronic dosing regimen but prior to drug administration for that day. The highest dose of rimonabant tested significantly decreased marble burying behavior, presumably anxiolysis. There were also significant effects in social interaction after chronic dosing. Our results did not reveal significant rimonabant-induced anxiogenic behaviors. Future studies to characterize behavioral screens for anxiogenic effects of CB1 antagonists in rodents should further explore social interaction paradigms and potential comorbid factors of rimonabant dosing such as sex, age, and obesity.
C1 [Ettaro, Robert; Clark, Stewart D.] Univ Buffalo, Jacobs Sch Med & Biomed Sci, Dept Pharmacol & Toxicol, Buffalo, NY USA.
   [Laudermilk, Lucas; Maitra, Rangan] RTI Int, Ctr Drug Discovery, Res Triangle Pk, NC USA.
C3 State University of New York (SUNY) System; University at Buffalo, SUNY;
   Research Triangle Institute
RP Maitra, R (corresponding author), POB 12194, Res Triangle Pk, NC 27709 USA.
EM rmaitra@rti.org
OI Laudermilk, Lucas/0000-0001-6181-0136
FU NIAAA NIH HHS [R01 AA022235] Funding Source: Medline; NIDDK NIH HHS [R01
   DK100414] Funding Source: Medline
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NR 42
TC 19
Z9 20
U1 1
U2 6
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0166-4328
EI 1872-7549
J9 BEHAV BRAIN RES
JI Behav. Brain Res.
PD JUL 15
PY 2020
VL 390
AR 112697
DI 10.1016/j.bbr.2020.112697
PG 10
WC Behavioral Sciences; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Behavioral Sciences; Neurosciences & Neurology
GA LW7LG
UT WOS:000539324300006
PM 32417279
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Beh, KH
   Chuah, KH
   Rappek, NAM
   Mahadeva, S
AF Beh, Keng Hau
   Chuah, Kee Huat
   Rappek, Nurul Azmi Mahamad
   Mahadeva, Sanjiv
TI The association of body mass index with functional dyspepsia is
   independent of psychological morbidity: A cross-sectional study
SO PLOS ONE
LA English
DT Article
ID IRRITABLE-BOWEL-SYNDROME; GASTROINTESTINAL DISORDERS; ROME III; SWEDISH
   POPULATION; HOSPITAL ANXIETY; DEPRESSION SCALE; IV CRITERIA; SYMPTOMS;
   VALIDATION; MALAYSIA
AB Background and aim
   The association between body mass index (BMI) and functional gastrointestinal disorders (FGIDs) has been inconsistent. We aimed to explore the association of BMI with FGIDs in a primary care setting to provide more data in this area.
   Methods
   A cross-sectional study of consecutive Asian adults attending a primary healthcare setting was conducted. This study was conducted in 2 phases: The association between BMI and common FGIDs (functional diarrhea/FD, irritable bowel syndrome/IBS, functional diarrhea and functional constipation/FC) was studied initially. The influence of anxiety and depression on BMI and FGIDs was additionally explored in phase 2.
   Results
   A total of 1002 subjects (median age 32 years, 65.4% females, 90.7% Malay ethnicity, 73.2% higher than secondary level education) were recruited between August 2019 to January 2020. The majority of subjects were obese (39.2%), and had central obesity (51.7%), while 6.1% had metabolic syndrome. The prevalence of FD, IBS, functional diarrhea and FC were 7.5% (n = 75), 4.0% (n = 40), 1.2% (n = 12) and 10.5% (n = 105) respectively, based on the Rome III criteria. Among individual FGIDs, FD subjects had more underweight adults (BMI<18.5kg/m(2)) compared to controls (13.3% vs 3.5%, P = 0.002) and being underweight remained as an independent association with FD [OR = 3.648 (95%CI 1.494-8.905), P = 0.004] at multi-variate analysis. There were no independent associations between BMI and other FGIDs. When psychological morbidity was additionally explored, anxiety (OR 2.032; 95%CI = 1.034-3.991, p = 0.040), but not depression, and a BMI<18.5kg/m(2) (OR 3.231; 95%CI = 1.066-9.796, p = 0.038) were found to be independently associated with FD.
   Conclusions
   FD, but not other FGIDs, is associated with being underweight. This association is independent of the presence of anxiety.
C1 [Beh, Keng Hau] Univ Malaya, Dept Med, Kuala Lumpur, Malaysia.
   [Chuah, Kee Huat; Mahadeva, Sanjiv] Univ Malaya, Dept Med, Gastroenterol & Hepatol Unit, Kuala Lumpur, Malaysia.
   [Rappek, Nurul Azmi Mahamad] Univ Malaya, Staff & Student Hlth Clin, Med Ctr, Kuala Lumpur, Malaysia.
C3 Universiti Malaya; Universiti Malaya; Universiti Malaya
RP Beh, KH (corresponding author), Univ Malaya, Dept Med, Kuala Lumpur, Malaysia.
EM chuah319@yahoo.com
RI Beh, Keng Hau/LXU-3765-2024; Chuah, Kee Huat/P-7852-2018; Mahadeva,
   Sanjiv/E-1711-2011
OI Beh, Keng Hau/0000-0003-3001-4051; Chuah, Kee Huat/0000-0001-9811-7546;
   Mahadeva, Sanjiv/0000-0001-5824-0590
FU University Malaya Specialist Centre (UMSC) C.A.R.E Research Fund
   [PV039-2019]
FX Author who received the grant: KHC. This study was funded by the
   University Malaya Specialist Centre (UMSC) C.A.R.E Research Fund
   (Project No.: PV039-2019). The funders had no role in study design, data
   collection and analysis, decision to publish, or preparation of the
   manuscript.
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NR 38
TC 24
Z9 25
U1 1
U2 17
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JAN 26
PY 2021
VL 16
IS 1
AR e0245511
DI 10.1371/journal.pone.0245511
PG 13
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Science & Technology - Other Topics
GA QA8QK
UT WOS:000613707100028
PM 33497382
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Deniz, F
   Katircibasi, MT
   Pamukcu, B
   Binici, S
   Sanisoglu, SY
AF Deniz, Ferhat
   Katircibasi, Mahmut Tuna
   Pamukcu, Burak
   Binici, Suleyman
   Sanisoglu, S. Yavuz
TI Association of metabolic syndrome with impaired heart rate recovery and
   low exercise capacity in young male adults
SO CLINICAL ENDOCRINOLOGY
LA English
DT Article
ID C-REACTIVE PROTEIN; CARDIOVASCULAR-DISEASE MORTALITY; ALL-CAUSE;
   CARDIORESPIRATORY FITNESS; PREDICTOR; GLUCOSE; FAILURE; HEALTH
AB Background Impaired heart rate recovery (HRR) is a powerful predictor of overall mortality.
   Aim The aim of the present study is to assess HRR in young adult males with metabolic syndrome and to compare HRR with those of obese patients who do not meet the criteria for metabolic syndrome.
   Patients and methods Sixty-four newly diagnosed and untreated young male subjects (24 +/- 3 years) with metabolic syndrome and 40 age and sex matched obese or overweight control subjects (ages 23 +/- 3 years) were enrolled in the study. All subjects performed a symptom limited exercise stress test under the standard Bruce protocol. HRR was calculated in the first, second and third minutes of the recovery period. The relationship between metabolic syndrome and HRR was evaluated via logistic regression analysis and a P-value < 0.05 was accepted as significant.
   Results Body mass index (BMI) was 38.6 +/- 3.68 and 32.22 +/- 2.99 kg/m(2) in the study and control groups, respectively (P < 0.001). Total cholesterol, low-density lipoprotein (LDL) cholesterol, triglycerides, systolic and diastolic blood pressures and fasting glucose levels were significantly higher in the study group. HRR in the first minute of the recovery period and mean exercise capacity were significantly lower in the study-group patients with metabolic syndrome (P < 0.001 and P = 0.012, respectively).
   Conclusion We determined that HRR was impaired in young adult males with metabolic syndrome compared with obese ones who do not meet the criteria of metabolic syndrome. This decreased HRR may have prognostic value in the prediction of vascular events in patients with metabolic syndrome.
C1 Etimesgut Mil Hosp, Dept Endocrinol & Metab, Ankara, Turkey.
   Etimesgut Mil Hosp, Dept Cardiol, Ankara, Turkey.
   Gulhane Mil Med Acad, Dept Biostat, Ankara, Turkey.
C3 Etimesgut Airforce Hospital; Etimesgut Airforce Hospital; Gulhane
   Military Medical Academy
RP Deniz, F (corresponding author), Etimesgut Mil Hosp, Dept Endocrinol & Metab, Ust Hava Lojmanlari A-7-7 Etimesgut, Ankara, Turkey.
EM ferhatdeniz20@yahoo.com
RI Pamukcu, Burak/AAN-3506-2020; Deniz, Ferhat/LWZ-9697-2024
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NR 34
TC 30
Z9 40
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0300-0664
EI 1365-2265
J9 CLIN ENDOCRINOL
JI Clin. Endocrinol.
PD FEB
PY 2007
VL 66
IS 2
BP 218
EP 223
DI 10.1111/j.1365-2265.2006.02711.x
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 125KU
UT WOS:000243441600010
PM 17223991
DA 2025-06-11
ER

PT J
AU McAninch, D
   Bianco-Miotto, T
   Gatford, KL
   Leemaqz, SY
   Andraweera, PH
   Garrett, A
   Plummer, MD
   Dekker, GA
   Roberts, CT
   Smithers, LG
   Grieger, JA
AF McAninch, Dale
   Bianco-Miotto, Tina
   Gatford, Kathy L.
   Leemaqz, Shalem Y.
   Andraweera, Prabha H.
   Garrett, Amy
   Plummer, Michelle D.
   Dekker, Gus A.
   Roberts, Claire T.
   Smithers, Lisa G.
   Grieger, Jessica A.
TI The metabolic syndrome in pregnancy and its association with child
   telomere length
SO DIABETOLOGIA
LA English
DT Article
DE Cardiovascular; Children; Developmental programming; Maternal; Metabolic
   syndrome; Obesity; Offspring; Pregnancy; Telomere length
ID CARDIOMETABOLIC OUTCOMES; OBESITY; BLOOD; PREDISPOSITION; STRESS; RISK
AB Aims/hypothesis The aim of this study was to determine whether presence of the metabolic syndrome in pregnancy associates with child telomere length or child anthropometry (weight, BMI) and BP, measured at 10 years of age.
   Methods The Screening for Pregnancy Endpoints study (SCOPE) was a multicentre, international prospective cohort of nulliparous pregnant women recruited from Australia, New Zealand, Ireland and the UK (N = 5628). The current analysis is a 10 year follow-up of SCOPE pregnant women and their children, from the Australian cohort. Clinical data collected at 14-16 weeks' gestation during the SCOPE study were used to diagnose the metabolic syndrome using IDF criteria. Telomere length, a biomarker of ageing, was assessed by quantitative PCR from children's saliva collected at 10 years of age.
   Results In women who completed follow-up (n = 255), 20% had the metabolic syndrome in pregnancy. After adjusting for a range of confounders, children of mothers who had the metabolic syndrome in pregnancy had 14% shorter telomeres than children of mothers without the metabolic syndrome in pregnancy (mean difference -0.36 [95% CI -0.74, 0.01]). Height- and weight-for-age, and BMIzscores were similar in children of mothers who did and did not have the metabolic syndrome during pregnancy.
   Conclusions/interpretation Children of mothers who had the metabolic syndrome in pregnancy have shorter telomeres, a biomarker of accelerated ageing. These findings warrant further studies in larger cohorts of children, as well as investigations into whether telomere length measured in cord blood associates with telomere length in childhood.
C1 [McAninch, Dale; Bianco-Miotto, Tina; Gatford, Kathy L.; Leemaqz, Shalem Y.; Andraweera, Prabha H.; Garrett, Amy; Plummer, Michelle D.; Dekker, Gus A.; Roberts, Claire T.; Smithers, Lisa G.; Grieger, Jessica A.] Univ Adelaide, Robinson Res Inst, Adelaide, SA 5005, Australia.
   [McAninch, Dale; Gatford, Kathy L.; Leemaqz, Shalem Y.; Andraweera, Prabha H.; Garrett, Amy; Plummer, Michelle D.; Roberts, Claire T.; Grieger, Jessica A.] Univ Adelaide, Adelaide Med Sch, Adelaide, SA, Australia.
   [Bianco-Miotto, Tina] Univ Adelaide, Sch Agr Food & Wine, Waite Res Inst, Adelaide, SA, Australia.
   [Leemaqz, Shalem Y.; Roberts, Claire T.] Flinders Univ S Australia, Coll Med & Publ Hlth, Bedford Pk, SA, Australia.
   [Dekker, Gus A.] Univ Adelaide, Lyell McEwin Hosp, Women & Childrens Div, Adelaide, SA, Australia.
   [Smithers, Lisa G.] Univ Adelaide, Sch Publ Hlth, Adelaide, SA, Australia.
C3 Robinson Research Institute; University of Adelaide; University of
   Adelaide; University of Adelaide; Flinders University South Australia;
   Lyell McEwin Hospital; University of Adelaide; University of Adelaide
RP Grieger, JA (corresponding author), Univ Adelaide, Robinson Res Inst, Adelaide, SA 5005, Australia.; Grieger, JA (corresponding author), Univ Adelaide, Adelaide Med Sch, Adelaide, SA, Australia.
EM jessica.grieger@adelaide.edu.au
RI Grieger, Jessica/V-4474-2019; Roberts, Claire/A-1205-2007; Gatford,
   Kathryn/B-8136-2013; Bianco-Miotto, Tina/C-4808-2008; Smithers,
   Lisa/D-1605-2009
OI McAninch, Dale/0000-0001-9735-6553; Gatford,
   Kathryn/0000-0002-2823-3004; Roberts, Claire/0000-0002-9250-2192;
   Leemaqz, Shalem/0000-0003-4616-8426; Bianco-Miotto,
   Tina/0000-0002-8431-5338; Smithers, Lisa/0000-0002-6585-7836; Plummer,
   Michelle/0000-0002-6398-011X
FU Premier's Science and Research Fund, South Australian Government;
   Channel 7 Children's Research Foundation [GNT 161305]; Emerging
   Leadership Mentored Development Program, Faculty of Health and Medical
   Sciences, University of Adelaide; Robinson Research Institute (RRI) Seed
   Grant; NHMRC Peter Doherty Early Career Fellowship [GNT1090778];
   Flinders University; University of Adelaide; NHMRC [GNT1174971]
FX SCOPE was funded by Premier's Science and Research Fund, South
   Australian Government
   (http://www.dfeest.sa.gov.au/scienceresearch/premiers-research-and-indus
   try-fund).The SCOPE follow-up study was funded by Channel 7 Children's
   Research Foundation Project Grant awarded to PHA, CTR and GAD (GNT
   161305). JAG was supported by an Emerging Leadership Mentored
   Development Program, Faculty of Health and Medical Sciences, University
   of Adelaide and a Robinson Research Institute (RRI) Seed Grant (TBM,
   CTR, KLG, JAG). PHA was supported by an NHMRC Peter Doherty Early Career
   Fellowship (GNT1090778). CTR is supported by aMatthew Flinders
   Fellowship from Flinders University and a NHMRC Investigator Grant
   (GNT1174971). AG and MDP received PhD Research Training Program
   scholarships from the University of Adelaide.
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NR 53
TC 24
Z9 24
U1 1
U2 17
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0012-186X
EI 1432-0428
J9 DIABETOLOGIA
JI Diabetologia
PD OCT
PY 2020
VL 63
IS 10
BP 2140
EP 2149
DI 10.1007/s00125-020-05242-0
EA JUL 2020
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA NK5IG
UT WOS:000553748200002
PM 32728890
OA Bronze
DA 2025-06-11
ER

PT J
AU Mazzone, L
   Postorino, V
   De Peppo, L
   Della Corte, C
   Lofino, G
   Vassena, L
   Fatta, L
   Armando, M
   Bedogni, G
   Vicari, S
   Nobili, V
AF Mazzone, Luigi
   Postorino, Valentina
   De Peppo, Lavinia
   Della Corte, Claudia
   Lofino, Giuseppe
   Vassena, Lia
   Fatta, Laura
   Armando, Marco
   Bedogni, Giorgio
   Vicari, Stefano
   Nobili, Valerio
TI Paediatric Non-Alcoholic Fatty Liver Disease: Impact on Patients and
   Mothers' Quality of Life
SO HEPATITIS MONTHLY
LA English
DT Article
DE Depression; Anxiety; Children; Chronic Disease; Adolescence
ID METABOLIC SYNDROME; STYLE INTERVENTION; INSULIN RESISTANCE;
   DOUBLE-BLIND; CHILDREN; DEPRESSION; ADOLESCENTS; OVERWEIGHT; GLUCOSE;
   STEATOHEPATITIS
AB Background: Non-alcoholic fatty liver disease (NAFLD) is one of the causes of fatty liver in adults and is currently the primary form of chronic liver disease in children and adolescents. However, the psychological outcome (i.e. the behavioural problems that can in turn be related to psychiatric conditions, like anxiety and mood disorders, or lower quality of life) in children and adolescents suffering of NAFLD has not been extensively explored in the literature.
   Objectives: The present study aims at evaluating the emotional and behavioural profile in children suffering from NAFLD and the quality of life in their mothers.
   Patients and Methods: A total of 57 children (18 females/39 males) with NAFLD were compared to 39 age-matched control children (25 females/14 males). All participants were submitted to the following psychological tools to assess behavior, mood, and anxiety: the Multidimensional Anxiety Scale for Children (MASC), the Child Behavior Checklist (CBCL), and the Children's Depression Inventory (CDI). Moreover, the mothers of 40 NAFLD and 39 control children completed the World Health Organization Quality of Life-BREF (WHOQOL-BREF) questionnaire.
   Results: NAFLD children scored significantly higher as compared to control children in MASC (P = 0.001) and CDI total (P < 0.001) scales. The CBCL also revealed significantly higher scores for NAFLD children in total problems (P = 0.046), internalizing symptoms (P = 0.000) and somatic complaints (P < 0.001). The WHOQOL-BREF revealed significantly lower scores for the mothers of NAFLD children in the overall perception of the quality of life (P < 0.001), and in the "relationships" domain (P = 0.023).
   Conclusions: Increased emotional and behavioural problems were detected in children with NAFLD as compared to healthy control children, together with an overall decrease in their mothers' quality of life. These results support the idea that these patients may benefit from a psychological intervention, ideally involving both children and parents, whose quality of life is likely negatively affected by this disease.
C1 [Mazzone, Luigi; Postorino, Valentina; De Peppo, Lavinia; Vassena, Lia; Fatta, Laura; Armando, Marco; Vicari, Stefano] IRCCS Childrens Hosp Bambino Gesu, Child Neuropsychiat Unit, Dept Neurosci, I-00165 Rome, Italy.
   [Postorino, Valentina] Univ Roma La Sapienza, Dept Dynam & Clin Psychol, I-00185 Rome, Italy.
   [Della Corte, Claudia; Lofino, Giuseppe; Bedogni, Giorgio; Nobili, Valerio] IRCCS Childrens Hosp Bambino Gesu, Hepatometab Dis & Anesthesiol Unit, I-00165 Rome, Italy.
C3 IRCCS Bambino Gesu; Sapienza University Rome; IRCCS Bambino Gesu
RP Mazzone, L (corresponding author), IRCCS Childrens Hosp Bambino Gesu, Child Neuropsychiat Unit, Dept Neurosci, Piazza S Onofrio 4, I-00165 Rome, Italy.
EM gigimazzone@yahoo.it
RI VELLA, STEFANO/V-8440-2019; Nobili, Valerio/K-8670-2018; Fatta,
   Laura/GPX-2497-2022; Postorino, Valentina/AAA-6127-2019; Corte,
   Claudia/AAA-7478-2020; Mazzone, Luigi/AAC-5210-2022; Fatta, Laura
   Maria/K-5973-2016; Bedogni, Giorgio/K-1911-2018
OI Mazzone, Luigi/0000-0002-5287-3386; Vicari, Stefano/0000-0002-5395-2262;
   Fatta, Laura Maria/0000-0001-6451-8077; Postorino,
   Valentina/0000-0003-0142-4625; Armando, Marco/0000-0001-7074-7212;
   nobili, valerio/0000-0002-4570-3979; Bedogni,
   Giorgio/0000-0002-1495-9306
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NR 49
TC 20
Z9 21
U1 0
U2 14
PU KOWSAR PUBL
PI HOENSBROEK
PA PATERSWEG 22,, HOENSBROEK, LIMBURG 6431 GC, NETHERLANDS
SN 1735-143X
EI 1735-3408
J9 HEPAT MON
JI Hepat. Mon.
PD MAR
PY 2013
VL 13
IS 3
AR e7871
DI 10.5812/hepatmon.7871
PG 8
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 187MB
UT WOS:000322122100006
PM 23745129
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Krzystek-Korpacka, M
   Patryn, E
   Boehm, D
   Berdowska, I
   Zielinski, B
   Noczynska, A
AF Krzystek-Korpacka, Malgorzata
   Patryn, Eliza
   Boehm, Dorota
   Berdowska, Izabela
   Zielinski, Bogdan
   Noczynska, Anna
TI Advanced oxidation protein products (AOPPs) in juvenile overweight and
   obesity prior to and following weight reduction
SO CLINICAL BIOCHEMISTRY
LA English
DT Article
DE advanced oxidation protein products (AOPPs); insulin resistance;
   metabolic syndrome; juvenile obesity; oxidative stress; weight
   reduction; metformin; wheat bran; dyslipidemia
ID STRESS MARKERS; END-PRODUCTS; RISK-FACTORS; PLASMA; CHILDREN;
   INTERVENTIONS; ADOLESCENTS
AB Objectives: To evaluate the formation of advanced oxidation protein products (AOPPs) in juvenile overweight/obesity and obesity-related disorders and to investigate the effect of weight reduction on AOPPs.
   Design and methods: AOPPs were determined in 114 overweight/obese children and adolescents without/with insulin resistance and metabolic syndrome and compared with 53 lean controls. Measurements were repeated following weight reduction program (diet/exercise, bran-enriched diet/exercise, and diet/exercise plus metformin).
   Results: Overweight/obese subjects had higher AOPPs than lean controls, more elevated in patients with co-occurring metabolic syndrome. AOPPs positively correlated with central obesity, triglycerides, lipid peroxidation and insulin, and negatively with glucose to insulin ratio. AOPPs decreased following obesity intervention and Delta AOPPs correlated with Delta BMI%. AOPPs reduction was more pronounced in subjects on bran-enriched diet. Baseline AOPPs were a better predictor of clinically significant weight reduction than BMI%.
   Conclusions: Juvenile overweight/obesity was associated with AOPPs accumulation, more pronounced in metabolic syndrome. Body mass reduction decreased oxidative stress, with bran-enriched diet being more effective than diet/exercise alone. (C) 2008 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
C1 [Krzystek-Korpacka, Malgorzata; Boehm, Dorota; Berdowska, Izabela; Zielinski, Bogdan] Wroclaw Med Univ, Dept Med Biochem, PL-50368 Wroclaw, Poland.
   [Patryn, Eliza; Noczynska, Anna] Wroclaw Med Univ, Dept Endocrinol & Diabetol Children & Adolescents, PL-50368 Wroclaw, Poland.
   [Patryn, Eliza] Wroclaw Med Univ, Dept Ophthalmol, PL-50368 Wroclaw, Poland.
C3 Wroclaw Medical University; Wroclaw Medical University; Wroclaw Medical
   University
RP Krzystek-Korpacka, M (corresponding author), Wroclaw Med Univ, Dept Med Biochem, Ul Chalubinskiego 10, PL-50368 Wroclaw, Poland.
EM krzystek@bioch.am.wroc.pl
RI Berdowska, Izabela/AAZ-4016-2021; Krzystek-Korpacka,
   Małgorzata/ABA-4556-2021
CR [Anonymous], EU PLATF DIET PHYS A
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NR 39
TC 62
Z9 66
U1 1
U2 6
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0009-9120
EI 1873-2933
J9 CLIN BIOCHEM
JI Clin. Biochem.
PD AUG
PY 2008
VL 41
IS 12
BP 943
EP 949
DI 10.1016/j.clinbiochem.2008.04.024
PG 7
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA 330ZF
UT WOS:000257980700004
PM 18501708
DA 2025-06-11
ER

PT J
AU McIntyre, RS
AF McIntyre, Roger S.
TI Understanding Needs, Interactions, Treatment, and Expectations Among
   Individuals Affected by Bipolar Disorder or Schizophrenia: The UNITE
   Global Survey
SO JOURNAL OF CLINICAL PSYCHIATRY
LA English
DT Article; Proceedings Paper
CT Teleconference on Balancing the Equation - Managing Comorbidities in
   Patients With Severe Mental Illness
CY AUG, 2008
CL ELECTR NETWORK
ID METABOLIC SYNDROME; MENTAL-HEALTH; OBESITY; PREVALENCE
AB Objective: The overarching aim of the Understanding Patients' Needs, Interactions, Treatment, and Expectations (UNITE) Global Survey was to empirically evaluate the attitudes and general fund of knowledge that individuals with bipolar disorder or schizophrenia possess regarding somatic health issues. Method: The UNITE survey was an Internet-based initiative that recruited patients and caregivers from I I countries (Australia, Brazil, France, Greece, Germany, Italy, Spain, South Korea, Sweden, the United States, and the United Kingdom). Opinion Research Corporation, Princeton, NJ, conducted the UNITE survey between June 10, 2006, and September 11, 2006, and analyzed the results. Results: A total of 5,074 respondents participated in the survey. From this total sample, 1, 155 individuals with schizophrenia and 1,300 with bipolar disorder were self-identified. Psychiatrists were identified as the individuals primarily responsible for patients' medication prescription and surveillance of both psychological and physical health. The majority of respondents in both groups had been receiving medication for more than 5 years. Weight gain was the most commonly cited adverse event associated with medication use. Moreover, weight gain was identified as a contributing factor to general medical comorbidity (eg, diabetes mellitus) and as a detractor to quality of life. Most respondents identified weight gain and general physical health as areas of deficiency in their perceived knowledge and interactions with health care providers. Notwithstanding the ubiquity and implications of comorbid medical disorders and medication-related adverse events, most respondents did not receive opportunistic screening or surveillance for medical risk factors and disorders. Overall, respondents expressed general dissatisfaction when interacting with mental health care providers. Conclusion: Metabolic consequences of psychotropic medication are the most concerning aspect of medication treatment for patients, contributing to perceived morbidity, quality-of-life reduction, and reduced satisfaction with care. Despite the compelling database that underscores the hazards attributable to comorbid general medical conditions, most individuals with schizophrenia and bipolar disorder receive guideline-discordant care for somatic health conditions as well as for the principal psychiatric disorder. Barriers to somatic health care access for those with schizophrenia and bipolar disorder, as well as the impact of targeted interventions, warrant future research. (J Clin Psychiatry 2009;70[suppl 3]:5-11)
C1 [McIntyre, Roger S.] Univ Toronto, Dept Psychiat, Toronto, ON M5T 2S8, Canada.
   [McIntyre, Roger S.] Univ Toronto, Dept Pharmacol, Toronto, ON M5T 2S8, Canada.
   [McIntyre, Roger S.] Univ Toronto, Inst Med Sci, Toronto, ON M5T 2S8, Canada.
   [McIntyre, Roger S.] Univ Hlth Network, Mood Disorders Psychopharmacol Unit, Toronto, ON, Canada.
C3 University of Toronto; University of Toronto; University of Toronto;
   University of Toronto; University Health Network Toronto
RP McIntyre, RS (corresponding author), Univ Toronto, Dept Psychiat, 399 Bathurst St, Toronto, ON M5T 2S8, Canada.
EM roger.mcintyre@uhn.on.ca
RI McIntyre, Roger/AAU-1000-2020
CR Chinman M, 2004, J CLIN PSYCHIAT, V65, P1343, DOI 10.4088/JCP.v65n1008
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   MENTAL DISORDERS AM
NR 16
TC 47
Z9 50
U1 0
U2 12
PU PHYSICIANS POSTGRADUATE PRESS
PI MEMPHIS
PA P O BOX 752870, MEMPHIS, TN 38175-2870 USA
SN 0160-6689
EI 1555-2101
J9 J CLIN PSYCHIAT
JI J. Clin. Psychiatry
PY 2009
VL 70
SU 3
BP 5
EP 11
DI 10.4088/JCP.7075su1c.02
PG 7
WC Psychology, Clinical; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI); Conference Proceedings Citation Index - Science (CPCI-S); Conference Proceedings Citation Index - Social Science &amp; Humanities (CPCI-SSH)
SC Psychology; Psychiatry
GA 465BQ
UT WOS:000267556000002
PM 19570496
OA Bronze
DA 2025-06-11
ER

PT J
AU Ge, JY
   Ding, ZJ
   Song, Y
   Wang, FF
AF Ge, Jiyong
   Ding, Zhijian
   Song, Yu
   Wang, Fangfang
TI Smoking Dose Modifies the Association between C242T Polymorphism and
   Prevalence of Metabolic Syndrome in a Chinese Population
SO PLOS ONE
LA English
DT Article
ID CORONARY-ARTERY-DISEASE; INCREASED OXIDATIVE STRESS; NADPH OXIDASE;
   CIGARETTE-SMOKE; GENE POLYMORPHISM; SUPEROXIDE ANION; NAD(P)H OXIDASE;
   OBESITY; RISK; P22PHOX
AB Background: The C242T polymorphism of the CYBA gene that encodes p22phox, a component of NADPH oxidase, has been found to modulate superoxide production. Oxidase is a major source of the superoxide anion that contributes to individual components of metabolic syndrome. We examined the relationship of the C242T polymorphism with the prevalence of metabolic syndrome in a Chinese population, taking account of consumed cigarette amounts.
   Methodology/Principal Findings: In 870 participants, we collected biomarkers related to metabolic syndrome and detailed history of smoking and genotyped the C242T polymorphisms. After adjustment for covariates, the CT/TT genotypes were associated with a lower risk of metabolic syndrome (P = 0.0008). The odds of having metabolic syndrome in the CT/TT participants were 0.439 (95%CI: 0.265, 0.726), while for CC participants the odds were 1.110 (95%CI: 0.904, 1.362). There was significant (P = 0.014) interaction between the C242T polymorphism and smoking status in relation to the prevalence of metabolic syndrome. For smokers who smoke no less than 25 pack-years, those with CT/TT genotypes had lower risk of metabolic syndrome as compared with CC polymorphism carriers (P = 0.015). In the multiple regression analysis, the CT/TT genotypes were significantly associated with lower serum concentration of triglycerides both in all subjects and smokers; furthermore, the CT/TT genotypes were also related to smaller waist circumference in smokers.
   Conclusions: Our study suggests that the C242T gene polymorphism is indeed related to the prevalence of metabolic syndrome and smoking dose might modify this association.
C1 [Ge, Jiyong; Ding, Zhijian; Song, Yu; Wang, Fangfang] Nanjing Med Univ, Changzhou Peoples Hosp 2, Dept Cardiol, Changzhou, Peoples R China.
C3 Nanjing Medical University
RP Ge, JY (corresponding author), Nanjing Med Univ, Changzhou Peoples Hosp 2, Dept Cardiol, Changzhou, Peoples R China.
EM zhijian_ding@yahoo.com
RI Wang, Fang-Fang/GRF-2972-2022
FU Health Bureau of Changzhou, China [SN200803]
FX This study was supported by grants from the Health Bureau of Changzhou,
   China (SN200803). The funders had no role in study design, data
   collection and analysis, decision to publish, or preparation of the
   manuscript.
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NR 36
TC 7
Z9 11
U1 0
U2 2
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAR 1
PY 2012
VL 7
IS 3
AR e31926
DI 10.1371/journal.pone.0031926
PG 6
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 928SU
UT WOS:000303005000011
PM 22396743
OA Green Submitted, gold, Green Published
DA 2025-06-11
ER

PT J
AU Courties, A
   Sellam, J
   Berenbaum, F
AF Courties, Alice
   Sellam, Jeremie
   Berenbaum, Francis
TI Metabolic syndrome-associated osteoarthritis
SO CURRENT OPINION IN RHEUMATOLOGY
LA English
DT Review
DE diabetes; inflammation; metabolic syndrome; obesity; osteoarthritis
ID GLYCATION END-PRODUCTS; ECTOPIC BONE-FORMATION; HIGH-FAT DIET; KNEE
   OSTEOARTHRITIS; DIABETES-MELLITUS; MITOCHONDRIAL DYSFUNCTION; HUMAN
   CHONDROCYTES; FISH-OIL; INFLAMMATION; SEVERITY
AB Purpose of review
   Interest in the metabolic syndrome-associated osteoarthritis phenotype is increasing. Here, we summarize recently published significant findings.
   Recent findings
   Meta-analyses confirmed an association between type 2 diabetes and osteoarthritis and between cardiovascular diseases and osteoarthritis. Recent advances in the study of metabolic syndrome-associated osteoarthritis have focused on a better understanding of the role of metabolic diseases in inducing or aggravating joint damage. In-vivo models of obesity, diabetes, or dyslipidemia have helped to better decipher this association. They give emerging evidence that, beyond the role of common pathogenic mechanisms for metabolic diseases and osteoarthritis (i.e., low-grade inflammation and oxidative stress), metabolic diseases have a direct systemic effect on joints. In addition to the impact of weight, obesity-associated inflammation is associated with osteoarthritis severity and may modulate osteoarthritis progression in mouse models. As well, osteoarthritis synovium from type 2 diabetic patients shows insulinresistant features, which may participate in joint catabolism. Finally, exciting data are emerging on the association of gut microbiota and circadian rhythm and metabolic syndrome-associated osteoarthritis.
   Summary
   The systemic role of metabolic syndrome in osteoarthritis pathophysiology is now better understood, but new avenues of research are being pursued to better decipher the metabolic syndrome-associated osteoarthritis phenotype.
C1 [Courties, Alice; Sellam, Jeremie; Berenbaum, Francis] St Antoine Hosp, AP HP, Rheumatol Dept, DHU I2B, Paris, France.
   [Courties, Alice; Sellam, Jeremie; Berenbaum, Francis] UPMC Univ Paris 06, INSERM, UMR S 938, DHU I2B, Paris, France.
C3 Assistance Publique Hopitaux Paris (APHP); Sorbonne Universite; Hopital
   Universitaire Saint-Antoine - APHP; Institut National de la Sante et de
   la Recherche Medicale (Inserm); Sorbonne Universite
RP Berenbaum, F (corresponding author), Hop St Antoine, Serv Rhumatol, 184 Rue Faubourg St Antoine, F-75012 Paris, France.
EM francis.berenbaum@aphp.fr
RI Berenbaum, Francis/AAO-5690-2020
OI berenbaum, francis/0000-0001-8252-7815
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NR 69
TC 169
Z9 182
U1 6
U2 64
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1040-8711
EI 1531-6963
J9 CURR OPIN RHEUMATOL
JI Curr. Opin. Rheumatol.
PD MAR
PY 2017
VL 29
IS 2
BP 214
EP 222
DI 10.1097/BOR.0000000000000373
PG 9
WC Rheumatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Rheumatology
GA ET6NQ
UT WOS:000400408800014
PM 28072592
DA 2025-06-11
ER

PT J
AU Charalampidi, A
   Kordou, Z
   Tsermpini, EE
   Bosganas, P
   Chantratita, W
   Fukunaga, K
   Mushiroda, T
   Patrinos, GP
   Koromina, M
AF Charalampidi, Aggeliki
   Kordou, Zoe
   Tsermpini, Evangelia-Eirini
   Bosganas, Panagiotis
   Chantratita, Wasun
   Fukunaga, Koya
   Mushiroda, Taisei
   Patrinos, George P.
   Koromina, Maria
TI Pharmacogenomics variants are associated with BMI differences between
   individuals with bipolar and other psychiatric disorders
SO PHARMACOGENOMICS
LA English
DT Article
DE ANCOVA; body mass index; covariate; NGS; pharmacogenes; psychiatric
   diseases
ID BODY-MASS INDEX; SINGLE-NUCLEOTIDE POLYMORPHISMS; OF-FUNCTION VARIANTS;
   GENETIC POLYMORPHISMS; WEIGHT-GAIN; METABOLIC SYNDROME; OBESITY; RISK;
   SUSCEPTIBILITY; ABCB1
AB Aim: Regardless of the plethora of next-generation sequencing studies in the field of pharmacogenomics (PGx), the potential effect of covariate variables on PGx response within deeply phenotyped cohorts remains unexplored. Materials & methods: We explored with advanced statistical methods the potential influence of BMI, as a covariate variable, on PGx response in a Greek cohort with psychiatric disorders. Results: Nine PGx variants within UGT1A6, SLC22A4, GSTP1, CYP4B1, CES1, SLC29A3 and DPYD were associated with altered BMI in different psychiatric disorder groups. Carriers of rs2070959 (UGT1A6), rs199861210 (SLC29A3) and rs2297595 (DPYD) were also characterized by significant changes in the mean BMI, depending on the presence of psychiatric disorders. Conclusion: Specific PGx variants are significantly associated with BMI in a Greek cohort with psychiatric disorders.
C1 [Charalampidi, Aggeliki; Kordou, Zoe; Tsermpini, Evangelia-Eirini; Bosganas, Panagiotis; Patrinos, George P.; Koromina, Maria] Univ Patras, Sch Hlth Sci, Dept Pharm, Patras, Greece.
   [Chantratita, Wasun] Mahidol Univ, Fac Med, Ctr Med Genom, Ramathibodi Hosp, Bangkok, Thailand.
   [Fukunaga, Koya; Mushiroda, Taisei] RIKEN Ctr Integrat Med Sci, Lab Pharmacogen, Yokohama, Kanagawa, Japan.
   [Koromina, Maria] Golden Helix Fdn, London, England.
   [Patrinos, George P.] United Arab Emirates Univ, Zayed Ctr Hlth Sci, Al Ain, U Arab Emirates.
   [Patrinos, George P.] United Arab Emirates Univ, Coll Med & Hlth Sci, Dept Pathol, Al Ain, U Arab Emirates.
C3 University of Patras; Mahidol University; RIKEN; United Arab Emirates
   University; United Arab Emirates University
RP Koromina, M (corresponding author), Univ Patras, Sch Hlth Sci, Dept Pharm, Patras, Greece.; Koromina, M (corresponding author), Golden Helix Fdn, London, England.
EM mkoromina@upnet.gr
RI Chantratita, Wasun/MGW-3655-2025; Patrinos, George/C-2845-2009;
   Fukunaga, Koya/C-4180-2017; Tsermpini, Evangelia Eirini/AAV-3824-2020
OI Patrinos, George/0000-0002-0519-7776; Fukunaga,
   Koya/0000-0002-5241-6062; Koromina, Maria/0000-0001-8843-082X;
   Tsermpini, Evangelia Eirini/0000-0002-8592-7790
FU European Commission [H2020-668353]
FX This study was partly funded by a European Commission grant
   (H2020-668353; U-PGx) to GP Patrinos. The authors have no other relevant
   affiliations or financial involvement with any organization or entity
   with a financial interest in or financial conflict with the subject
   matter or materials discussed in the manuscript apart from those
   disclosed.
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NR 66
TC 0
Z9 0
U1 0
U2 1
PU FUTURE MEDICINE LTD
PI LONDON
PA UNITEC HOUSE, 3RD FLOOR, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON, N3
   1QB, ENGLAND
SN 1462-2416
EI 1744-8042
J9 PHARMACOGENOMICS
JI Pharmacogenomics
PD AUG
PY 2021
VL 22
IS 12
BP 749
EP 760
DI 10.2217/pgs-2021-0012
EA AUG 2021
PG 12
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Pharmacology & Pharmacy
GA UM1EW
UT WOS:000686227600001
PM 34410167
DA 2025-06-11
ER

PT J
AU DeLay, KJ
   Haney, N
   Hellstrom, WJG
AF DeLay, Kenneth J.
   Haney, Nora
   Hellstrom, Wayne J. G.
TI Modifying Risk Factors in the Management of Erectile Dysfunction: A
   Review
SO WORLD JOURNAL OF MENS HEALTH
LA English
DT Review
DE Erectile dysfunction; Hypogonadism; Risk reduction behavior
ID LATE-ONSET HYPOGONADISM; QUALITY-OF-LIFE; ANDROGEN REPLACEMENT THERAPY;
   RANDOMIZED CONTROLLED-TRIAL; CONTROLLED CLINICAL-TRIAL; IMPROVES SEXUAL
   FUNCTION; NITRIC-OXIDE SYNTHASE; TESTOSTERONE GEL; METABOLIC SYNDROME;
   STYLE CHANGES
AB Erectile dysfunction (ED) is prevalent among men and its presence is often an indicator of systemic disease. Risk factors for ED include cardiovascular disease, hypertension, diabetes mellitus (DM), tobacco use, hyperlipidemia, hypogonadism, lower urinary tract symptoms, metabolic syndrome, and depression. Addressing the modifiable risk factors frequently improves a patient's overall health and increases lifespan. The literature suggests that smoking cessation, treatment of hyperlipidemia, and increasing physical activity will improve erectile function in many patients. How the treatment of DM, depression, and hypogonadism impacts erectile function is less clear. Clinicians need to be aware that certain antihypertensive agents can adversely impact erectile function. The treatment of men with ED needs to address the underlying risk factors to ameliorate the disease process.
C1 [DeLay, Kenneth J.; Haney, Nora; Hellstrom, Wayne J. G.] Tulane Univ, Sch Med, Dept Urol, New Orleans, LA 70112 USA.
C3 Tulane University
RP Hellstrom, WJG (corresponding author), Tulane Univ, Hlth Sci Ctr, Dept Urol, 1430 Tulane Ave,86-42, New Orleans, LA 70112 USA.
EM whellst@tulane.edu
RI Haney, Nora/IXD-8540-2023
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NR 99
TC 64
Z9 65
U1 0
U2 8
PU KOREAN SOC SEXUAL MEDICINE & ANDROLOGY
PI GWANGJU
PA DEPT UROLOGY, CHONNAM NATL UNIV MEDICAL SCH, 671 JEBONG-RO, DONG-GU,
   GWANGJU, 501-757, SOUTH KOREA
SN 2287-4208
EI 2287-4690
J9 WORLD J MENS HEALTH
JI World J. Mens Health
PD AUG
PY 2016
VL 34
IS 2
BP 89
EP 100
DI 10.5534/wjmh.2016.34.2.89
PG 12
WC Andrology; Health Care Sciences & Services; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Health Care Sciences & Services; Urology &
   Nephrology
GA DV3UY
UT WOS:000382850600003
PM 27574592
OA gold, Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Ohkuma, T
   Fujii, H
   Iwase, M
   Ogata-Kaizu, S
   Ide, H
   Kikuchi, Y
   Idewaki, Y
   Jodai, T
   Hirakawa, Y
   Nakamura, U
   Kitazono, T
AF Ohkuma, Toshiaki
   Fujii, Hiroki
   Iwase, Masanori
   Ogata-Kaizu, Shinako
   Ide, Hitoshi
   Kikuchi, Yohei
   Idewaki, Yasuhiro
   Jodai, Tamaki
   Hirakawa, Yoichiro
   Nakamura, Udai
   Kitazono, Takanari
TI U-shaped association of sleep duration with metabolic syndrome and
   insulin resistance in patients with type 2 diabetes: The Fukuoka
   Diabetes Registry
SO METABOLISM-CLINICAL AND EXPERIMENTAL
LA English
DT Article
DE Cardiovascular risk; C-reactive protein; Epidemiology; Sleep; Type 2
   diabetes mellitus
ID CARDIOVASCULAR-DISEASE; GLUCOSE-METABOLISM; RISK; IMPACT; DEPRESSION;
   RESTRICTION; POPULATION; MARKERS; OBESITY; APNEA
AB Objective. Sleep duration is suggested to be associated with adverse health outcomes. However, few studies are available on the impact of sleep duration on metabolic syndrome in patients with diabetes, who were at high risk for cardiovascular diseases (CVD). The objective of the present study was to examine the associations of sleep duration with metabolic syndrome and insulin resistance, a major pathophysiologic feature of metabolic syndrome, in patients with type 2 diabetes.
   Materials/Methods. A total of 4402 Japanese patients with type 2 diabetes aged >= 20 years were divided into 5 groups according to self-reported sleep duration: less than 5.5 h, 5.5-6.4 h, 6.5-7.4 h, 7.5-8.4 h, and more than 8.5 h. The associations of sleep duration with metabolic syndrome and other cardiovascular risk factors were examined cross-sectionally.
   Results. The proportions of patients who had metabolic syndrome increased significantly in both patients with shorter and longer sleep duration compared with those with 6.5-7.4 h of sleep (P for quadratic trend <0.001). This U-shaped association remained significant after adjustment for potential confounders, including total energy intake, current smoking, current drinking and depressive symptoms. Each component of metabolic syndrome also showed similar trends. Furthermore, sleep duration had a quadratic association with homeostasis model assessment of insulin resistance and high sensitivity C-reactive protein.
   Conclusions. Sleep duration was shown to have a U-shaped relationship with metabolic syndrome and insulin resistance, independent of potential confounders, and therefore may be an important modifiable risk factor for CVD prevention in patients with type 2 diabetes. (C) 2014 Elsevier Inc. All rights reserved.
C1 [Ohkuma, Toshiaki; Fujii, Hiroki; Iwase, Masanori; Ogata-Kaizu, Shinako; Ide, Hitoshi; Kikuchi, Yohei; Idewaki, Yasuhiro; Jodai, Tamaki; Nakamura, Udai; Kitazono, Takanari] Kyushu Univ, Grad Sch Med Sci, Dept Med & Clin Sci, Fukuoka 8128582, Japan.
   [Hirakawa, Yoichiro] Kyushu Univ, Grad Sch Med Sci, Dept Environm Med, Fukuoka 8128582, Japan.
   [Ohkuma, Toshiaki] Fukuoka Dent Coll Med & Dent Hosp, Dept Internal Med, Fukuoka, Japan.
   [Iwase, Masanori] Hakujyuji Hosp, Ctr Diabet, Fukuoka, Japan.
C3 Kyushu University; Kyushu University; Fukuoka Dental College (FDC)
RP Iwase, M (corresponding author), Kyushu Univ, Grad Sch Med Sci, Dept Med & Clin Sci, Higashi Ku, Maidashi 3-1-1, Fukuoka 8128582, Japan.
EM iwase@intmed2.med.kyushu-u.ac.jp
FU JSPS KAKENHI [23249037, 23659353]; Japan Diabetes Foundation;
   Grants-in-Aid for Scientific Research [23249037] Funding Source: KAKEN
FX This work was supported in part by JSPS KAKENHI (grant numbers 23249037,
   23659353) for MI and the grant from the Japan Diabetes Foundation for
   TO.
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NR 41
TC 63
Z9 70
U1 0
U2 11
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0026-0495
EI 1532-8600
J9 METABOLISM
JI Metab.-Clin. Exp.
PD APR
PY 2014
VL 63
IS 4
BP 484
EP 491
DI 10.1016/j.metabol.2013.12.001
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA AE0MB
UT WOS:000333659300007
PM 24411997
DA 2025-06-11
ER

PT J
AU Rahimi, VB
   Askari, VR
   Hosseinzadeh, H
AF Rahimi, Vafa Baradaran
   Askari, Vahid Reza
   Hosseinzadeh, Hossein
TI Promising influences of Scutellaria baicalensis and its two
   active constituents, baicalin, and baicalein, against metabolic
   syndrome: A review
SO PHYTOTHERAPY RESEARCH
LA English
DT Review
DE diabetes; dyslipidemia; metabolic syndrome; obesity; Scutellaria
   baicalensis
ID PULMONARY ARTERIAL-HYPERTENSION; RENIN-ANGIOTENSIN SYSTEM; NF-KAPPA-B;
   ALPHA-GLUCOSIDASE; OXIDATIVE STRESS; DENDRITIC CELLS; SMOOTH-MUSCLE;
   ADIPOCYTE DIFFERENTIATION; IN-VITRO; ISCHEMIA/REPERFUSION INJURY
AB Metabolic syndrome is known as a group of metabolic abnormalities with features including central obesity, insulin resistance, hypercholesterolemia, hypertriglyceridemia, and hypertension as well as low level of high-density lipoprotein (HDL)-cholesterol. Previous studies showed the ameliorating effects of Scutellaria baicalensis on metabolic syndrome parameters, including antidiabetic, anti-hyperlipidemic, anti-obesity, and antihypertensive. In this review, we deeply and mechanistically evaluated different studies on the effect of S. baicalensis and its two major bioactive constituents, baicalin, and baicalein, on the critical components of metabolic syndrome, including diabetes, hyperlipidemia, obesity, hypertension, and atherosclerosis. Scientific databases, including PubMed, Scopus, and Google Scholar were searched in the English language until the end of June 2020. Accordingly, S. baicalensis, and its two major bioactive constituents, baicalin and baicalein, represent promising effects on the control of metabolic syndrome and its related disorders such as obesity, hyperlipidemia, atherosclerosis, diabetes, and their following complications. In summary, our findings show that S. baicalensis and its active constituents, baicalin and baicalein, by activation and upregulation of AMPK and PPAR-gamma as the main signaling in the hemostasis of glucose and lipid metabolisms may be favorable candidates for the prevention and treatment of the metabolic syndrome.
C1 [Rahimi, Vafa Baradaran; Askari, Vahid Reza] Mashhad Univ Med Sci, Pharmacol Res Ctr Med Plants, Mashhad, Razavi Khorasan, Iran.
   [Rahimi, Vafa Baradaran; Askari, Vahid Reza] Mashhad Univ Med Sci, Sch Persian & Complementary Med, Dept Pharmaceut Sci Persian Med, Mashhad, Razavi Khorasan, Iran.
   [Askari, Vahid Reza] Mashhad Univ Med Sci, Appl Biomed Res Ctr, Mashhad, Razavi Khorasan, Iran.
   [Askari, Vahid Reza] Mashhad Univ Med Sci, Sch Persian & Complementary Med, Dept Persian Med, Mashhad, Razavi Khorasan, Iran.
   [Hosseinzadeh, Hossein] Mashhad Univ Med Sci, Pharmaceut Res Ctr, Pharmaceut Technol Inst, Mashhad, Razavi Khorasan, Iran.
   [Hosseinzadeh, Hossein] Mashhad Univ Med Sci, Sch Pharm, Dept Pharmacodynam & Toxicol, Mashhad, Razavi Khorasan, Iran.
C3 Mashhad University of Medical Sciences; Mashhad University of Medical
   Sciences; Mashhad University of Medical Sciences; Mashhad University of
   Medical Sciences; Mashhad University of Medical Sciences; Mashhad
   University of Medical Sciences
RP Hosseinzadeh, H (corresponding author), Mashhad Univ Med Sci, Pharmaceut Res Ctr, Pharmaceut Technol Inst, Mashhad, Razavi Khorasan, Iran.
EM hosseinzadehh@mums.ac.ir
RI Askari, Vahid Reza/ABB-8991-2020; Baradaran Rahimi, Vafa/AAR-4523-2021;
   Hosseinzadeh, Hossein/F-3013-2010
OI Hosseinzadeh, Hossein/0000-0002-3483-851X; Askari, Vahid
   Reza/0000-0001-9268-6270; Baradaran Rahimi, Vafa/0000-0003-2320-5095
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NR 135
TC 71
Z9 74
U1 4
U2 76
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0951-418X
EI 1099-1573
J9 PHYTOTHER RES
JI Phytother. Res.
PD JUL
PY 2021
VL 35
IS 7
BP 3558
EP 3574
DI 10.1002/ptr.7046
EA FEB 2021
PG 17
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA TS8TH
UT WOS:000618332100001
PM 33590943
DA 2025-06-11
ER

PT J
AU Yara, S
   Lavoie, JC
   Levy, E
AF Yara, Sabrina
   lavoie, Jean-ClauDe
   Levy, Emile
TI Oxidative stress and DNA methylation regulation in the metabolic
   syndrome
SO EPIGENOMICS
LA English
DT Review
DE antioxidant defense; DNA methylation; fetal programming; inflammation;
   metabolic syndrome; nutrition; oxidative stress
ID EXTRACELLULAR-SUPEROXIDE DISMUTASE; INTRAUTERINE GROWTH-RETARDATION;
   DIETARY-PROTEIN RESTRICTION; FOLIC-ACID SUPPLEMENTATION;
   RENIN-ANGIOTENSIN SYSTEM; DE-NOVO METHYLATION; FREE-RADICAL THEORY;
   EPIGENETIC REGULATION; INSULIN-RESISTANCE; NADPH OXIDASE
AB DNA methylation is implicated in tissue-specific gene expression and genomic imprinting. It is modulated by environmental factors, especially nutrition. Modified DNA methylation patterns may contribute to health problems and susceptibility to complex diseases. Current advances have suggested that the metabolic syndrome (MS) is a programmable disease, which is characterized by epigenetic modifications of vital genes when exposed to oxidative stress. Therefore, the main objective of this paper is to critically review the central context of MS while presenting the most recent knowledge related to epigenetic alterations that are promoted by oxidative stress. Potential pro-oxidant mechanisms that orchestrate changes in methylation profiling and are related to obesity, diabetes and hypertension are discussed. It is anticipated that the identification and understanding of the role of DNA methylation marks could be used to uncover early predictors and define drugs or diet-related treatments able to delay or reverse epigenetic changes, thereby combating MS burden.
C1 [Yara, Sabrina; lavoie, Jean-ClauDe; Levy, Emile] Univ Montreal, CHU St Justine, Res Ctr, Fac Med, Montreal, PQ H3T 1C5, Canada.
   [lavoie, Jean-ClauDe; Levy, Emile] Univ Montreal, Dept Nutr, Montreal, PQ H3T 1C5, Canada.
C3 Universite de Montreal; Centre Hospitalier Universitaire Sainte-Justine;
   Universite de Montreal
RP Levy, E (corresponding author), Univ Montreal, CHU St Justine, Res Ctr, Fac Med, Montreal, PQ H3T 1C5, Canada.
EM emile.levy@recherche-ste-justine.qc.ca
RI Lavoie, Jean-claude/K-2701-2016
FU JA DeSeve Research Chair in Nutrition
FX This study was supported by the JA DeSeve Research Chair in Nutrition.
   The authors have no other relevant affiliations or financial involvement
   with any organization or entity with a financial interest in or
   financial conflict with the subject matter or materials discussed in the
   manuscript apart from those disclosed.
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NR 151
TC 72
Z9 78
U1 0
U2 20
PU FUTURE MEDICINE LTD
PI LONDON
PA UNITEC HOUSE, 3RD FLOOR, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON, N3
   1QB, ENGLAND
SN 1750-1911
EI 1750-192X
J9 EPIGENOMICS-UK
JI Epigenomics
PY 2015
VL 7
IS 2
BP 283
EP 300
DI 10.2217/EPI.14.84
PG 18
WC Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Genetics & Heredity
GA CH5TF
UT WOS:000354097500012
PM 25942536
DA 2025-06-11
ER

PT J
AU Reljic, D
   Frenk, F
   Herrmann, HJ
   Neurath, MF
   Zopf, Y
AF Reljic, Dejan
   Frenk, Fabienne
   Herrmann, Hans J.
   Neurath, Markus F.
   Zopf, Yurdaguel
TI Low-volume high-intensity interval training improves cardiometabolic
   health, work ability and well-being in severely obese individuals: a
   randomized-controlled trial sub-study
SO JOURNAL OF TRANSLATIONAL MEDICINE
LA English
DT Article
DE Obesity; Metabolic syndrome; High-intensity interval training; Aerobic
   exercise; Cardiorespiratory fitness; Weight loss; Psychological health;
   Work ability
ID ALL-CAUSE MORTALITY; PHYSICAL-ACTIVITY; WEIGHT-LOSS; CARDIORESPIRATORY
   FITNESS; BLOOD-PRESSURE; OVERWEIGHT; EXERCISE; ADULTS; MASS;
   METAANALYSIS
AB BackgroundObesity is associated with impaired health and lower work ability. Increased physical activity is a cornerstone in the treatment of obesity and related risk factors. Recently, high-intensity interval training (HIIT) has emerged as a popular exercise option. However, data regarding the effects on cardiometabolic health, perceived work ability and well-being in severely obese individuals are lacking.MethodsSixty-five obese individuals with sedentary occupation (48.79.9 years, BMI: 39.67.1 kg/m(2)) were randomly allocated to an extremely time-efficient HIIT (5x1 min at 80-95% maximal heart rate on cycle ergometers, 2x/week for 12 weeks) or an inactive control group (CON). Both groups received nutritional counseling to support weight loss. Primary outcome was maximal oxygen uptake (VO2max), secondary outcomes were cardiometabolic risk indices, body composition, work ability index (WAI), quality of life (QoL, EQ-5D-5L-questionnaire) and perceived stress (PSQ-questionnaire).ResultsMean body weight reduction was 5.3 kg [95% confidence interval (95% CI) -7.3 to -3.3 kg] in the HIIT group (P<0.001) and 3.7 kg (95% CI -5.3 to -2.1 kg) in CON (P<0.001), respectively. Only the HIIT group showed significant (P<0.001) changes in VO2max [+3.5 mL/kg/min (95% CI 2.5 to 4.6 mL/kg/min)], waist circumference [-7.5 cm (95% CI -9.8 to -5.1 kg)], mean arterial blood pressure [-11 mmHg (95% CI -14 to -8 mmHg)], WAI [+3.0 points (95% CI 1.7 to 4.3 points)] and QoL [+10% (95% CI 5 to 16%)]. In CON, none of these parameters improved significantly.Conclusions Low-volume HIIT may induce significant improvements in cardiometabolic health, especially VO2max, WAI and well-being in obese individuals after only 12 weeks. Our results underpin the wide range of benefits on health and subjective measures through exercise that go well beyond simple weight loss through dietary restriction alone.Trial registration: ClinicalTrials.gov Id: NCT03306069. Registered 10 October 2017, https://clinicaltrials.gov/ct2/show/NCT03306069.
C1 [Reljic, Dejan; Frenk, Fabienne; Herrmann, Hans J.; Zopf, Yurdaguel] Friedrich Alexander Univ Erlangen Nurnberg, Univ Hosp Erlangen, Hector Ctr Nutr Exercise & Sports, Dept Med 1, Ulmenweg 18, D-91054 Erlangen, Germany.
   [Neurath, Markus F.] Friedrich Alexander Univ Erlangen Nurnberg, Dept Med 1, Univ Hosp Erlangen, Erlangen, Germany.
C3 University of Erlangen Nuremberg; University of Erlangen Nuremberg
RP Reljic, D (corresponding author), Friedrich Alexander Univ Erlangen Nurnberg, Univ Hosp Erlangen, Hector Ctr Nutr Exercise & Sports, Dept Med 1, Ulmenweg 18, D-91054 Erlangen, Germany.
EM dejan.reljic@uk-erlangen.de
RI Reljic, Dejan/CAG-1377-2022
OI Reljic, Dejan/0000-0001-8049-1775
FU Projekt DEAL; H.W. & J. Hector Foundation; Manfred Roth Foundation;
   Research Foundation for Medicine at the University Hospital Erlangen
FX Open Access funding enabled and organized by Projekt DEAL. This study
   has been supported by the H.W. & J. Hector Foundation, the Manfred Roth
   Foundation and Research Foundation for Medicine at the University
   Hospital Erlangen.
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TC 31
Z9 34
U1 4
U2 32
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1479-5876
J9 J TRANSL MED
JI J. Transl. Med.
PD NOV 7
PY 2020
VL 18
IS 1
AR 419
DI 10.1186/s12967-020-02592-6
PG 15
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA OT2SS
UT WOS:000590702200005
PM 33160382
OA Green Published, gold
DA 2025-06-11
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TI Serum klotho as a novel biomarker for metabolic syndrome: findings from
   a large national cohort
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Article
DE metabolic syndrome; klotho; mortality; biomarkers; NHANES
ID GROWTH-FACTOR 23; CARDIOVASCULAR-DISEASE; OXIDATIVE STRESS;
   KIDNEY-DISEASE; RISK; MORTALITY; PREVALENCE; PATHOPHYSIOLOGY;
   MECHANISMS; HEALTH
AB Background Metabolic syndrome is a cluster of metabolic abnormalities that significantly increase the risk of cardiovascular disease and mortality. The identification of novel biomarkers associated with mortality in patients with metabolic syndrome could facilitate early risk stratification and targeted interventions.Methods We conducted a large prospective cohort study using data from five cycles (2009-2016) of the National Health and Nutrition Examination Survey (NHANES) database, including a total of 40,439 participants. Logistic regression analysis was used to assess the association between serum klotho protein levels and metabolic syndrome, while Cox regression analysis was employed to examine the correlation between serum klotho levels and all-cause mortality. Mortality data were updated until December 31, 2019.Results After adjusting for demographic and socioeconomic confounders, the logistic regression model demonstrated that higher serum klotho levels were significantly associated with a decreased prevalence of metabolic syndrome (OR [95% CI] Highest vs. lowest quartile: 0.84 [0.70-0.99], P=0.038). In the Cox regression model, elevated klotho levels were found to significantly reduce the risk of all-cause mortality among individuals with metabolic syndrome (HR [95% CI] Highest vs. lowest quartile: 0.68 [0.51-0.90], P=0.006).Conclusion Serum klotho levels were found to be inversely associated with the prevalence of metabolic syndrome, independent of potential confounding factors such as demographics, socioeconomic status, and lifestyle factors. Furthermore, higher klotho levels strongly indicated a lower risk of all-cause mortality in individuals with metabolic syndrome.
C1 [Yuguang, Li; Chen, Naifei; Zhao, Yixin; Zhang, Xinwei; Song, Wei; Lu, Jin; Liu, Xiangliang] First Hosp Jilin Univ, Canc Ctr, Changchun, Peoples R China.
   [Chang, Yu] First Hosp Jilin Univ, Dept Gastroenterol, Changchun, Peoples R China.
C3 Jilin University; Jilin University
RP Song, W; Lu, J; Liu, XL (corresponding author), First Hosp Jilin Univ, Canc Ctr, Changchun, Peoples R China.
EM songwei726@jlu.edu.cn; lujin001@jlu.edu.cn; ds9291@qq.com
RI yu, jin/HNI-8342-2023; Liu, Xiangliang/HDO-7937-2022
OI /0000-0003-3082-2745
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NR 38
TC 7
Z9 7
U1 0
U2 4
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD MAR 4
PY 2024
VL 15
AR 1295927
DI 10.3389/fendo.2024.1295927
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA LH8A4
UT WOS:001185978700001
PM 38501099
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Usta, M
   Turan, E
   Aral, H
   Inal, BB
   Gurel, MS
   Guvenen, G
AF Usta, Murat
   Turan, Enver
   Aral, Hale
   Inal, Berrin Bercik
   Gurel, Mehmet Salih
   Guvenen, Guvenc
TI Serum Paraoxonase-1 Activities and Oxidative Status in Patients With
   Plaque-Type Psoriasis With/Without Metabolic Syndrome
SO JOURNAL OF CLINICAL LABORATORY ANALYSIS
LA English
DT Article
DE metabolic syndrome; oxidative stress; paraoxonase-1; psoriasis
ID LIPOPROTEIN PARTICLES; DENSITY-LIPOPROTEIN; DIABETES-MELLITUS;
   ANTIOXIDANTS; ATHEROSCLEROSIS; INFLAMMATION; ASSOCIATION; PREVALENCE;
   OXIDANTS; DISEASE
AB Objective: Psoriasis is a chronic immune-mediated inflammatory skin disease associated with metabolic syndrome, which is made up of a cluster of disorders, including obesity, diabetes mellitus, dyslipidemia, and cardiovascular disease. The aim of this study was to investigate serum paraoxonase-1 activities and oxidative status parameters in patients with plaque-type psoriasis with or without metabolic syndrome. Methods: In this study, patients with plaque-type psoriasis with (n = 25) or without (n = 27) metabolic syndrome, according to the criteria of the International Diabetes Federation (IDF), were matched for age and sex to an equally sized control group (n = 25). Results: In patients without metabolic syndrome, serum paraoxonase and arylesterase activities showed mean decreases of 29 and 6%, respectively, whereas in patients with metabolic syndrome, the mean decreases in the enzymes' activities were 35 and 11%, respectively, compared with those in the control group. Serum total antioxidant capacity and total oxidant status were not statistically significant in any of the three groups. Multiple linear regression analysis revealed that HDL cholesterol and log-transformed triglyceride were independent variables for serum arylesterase activity and that fasting glucose and diastolic blood pressure were independent variables for serum paraoxonase activity. Conclusions: These results suggest that according to the criteria of the IDF, the significant decrease observed in serum paraoxonase activity was independent of the metabolic syndrome in patients with mild-to-moderate plaque-type psoriasis, whereas the significant decrease in serum arylesterase activity was associated with the metabolic syndrome. J. Clin. Lab. Anal. 25: 289-295, 2011. (C) 2011 Wiley-Liss, Inc.
C1 [Usta, Murat] Sivas Numune Hosp, Minist Hlth, Dept Med Biochem, TR-58040 Merkez, Sivas, Turkey.
   [Turan, Enver] Batman Reg Govt Hosp, Minist Hlth, Dept Dermatol, Batman, Turkey.
   [Aral, Hale; Inal, Berrin Bercik; Guvenen, Guvenc] Istanbul Res & Training Hosp, Minist Hlth, Dept Med Biochem, Istanbul, Turkey.
   [Gurel, Mehmet Salih] Istanbul Res & Training Hosp, Minist Hlth, Dept Dermatol, Istanbul, Turkey.
C3 Ministry of Health - Turkey; Ministry of Health - Turkey; Batman
   Regional State Hospital; Gercus State Hospital; Istanbul Training &
   Research Hospital; Ministry of Health - Turkey; Istanbul Bagcilar
   Training & Research Hospital; Istanbul Bagcilar Training & Research
   Hospital; Istanbul Training & Research Hospital; Ministry of Health -
   Turkey
RP Usta, M (corresponding author), Sivas Numune Hosp, Minist Hlth, Dept Med Biochem, TR-58040 Merkez, Sivas, Turkey.
EM muratxusta@hotmail.com
RI BercikInal, Berrin/MIK-5967-2025; Turan, Eylem/IQW-5912-2023; GUREL,
   Mehmet Salih/H-6161-2011
OI GUREL, Mehmet Salih/0000-0002-7031-6516
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NR 36
TC 30
Z9 30
U1 0
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 0887-8013
EI 1098-2825
J9 J CLIN LAB ANAL
JI J. Clin. Lab. Anal.
PY 2011
VL 25
IS 4
BP 289
EP 295
DI 10.1002/jcla.20471
PG 7
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA 803MY
UT WOS:000293586600009
PM 21786331
OA Green Published
DA 2025-06-11
ER

PT J
AU Mbata, O
   El-Magd, NFA
   El-Remessy, AB
AF Mbata, Osinakachukwu
   El-Magd, Nada Fawzy Abo
   El-Remessy, Azza Bahram
TI Obesity, metabolic syndrome and diabetic retinopathy: Beyond
   hyperglycemia
SO WORLD JOURNAL OF DIABETES
LA English
DT Review
DE Diabetic retinopathy; Diabetes; Metabolic syndrome; Oxidative stress;
   Inflammation; Insulin resistance
ID FATTY LIVER-DISEASE; RETINAL MICROVASCULAR SIGNS; BODY-MASS INDEX;
   INSULIN-RESISTANCE; RISK-FACTORS; ATHEROSCLEROSIS RISK; ENDOTHELIAL
   DYSFUNCTION; INFLAMMATORY CYTOKINES; INCREASED PREVALENCE;
   KIDNEY-DISEASE
AB Diabetic retinopathy (DR) is the most feared ocular manifestation of diabetes. DR is characterized by progressive retinal damage that may eventually result in blindness. Clinically, this blindness is caused by progressive damage to the retinal microvasculature, which leads to ischemia, retinal swelling, and neovascularization. Retinopathy is associated with both type 1 and type 2 diabetes, with DR being the leading cause of new onset blindness in United States adults. Despite this strong association with diabetes, it must be noted that the development of retinopathy lesions is multifactorial and may occur in individuals without an established history of diabetes. Metabolic syndrome is a multifactorial condition of central obesity, hypertriglyceridemia, dyslipidemia, hypertension, fasting hyperglycemia, and insulin resistance. Although several studies examined the individual components observed in the metabolic syndrome in relation to the development of DR, there is conflicting data as to the association of the metabolic syndrome with the development of retinopathy lesions in nondiabetic subjects. This review will summarize the current literature on the evidence of the metabolic syndrome on retinopathy in subjects with and without an established history of diabetes. This review will also discuss some of the mechanisms through which metabolic syndrome can contribute to the development of retinopathy.
C1 [Mbata, Osinakachukwu; El-Remessy, Azza Bahram] Univ Georgia, Coll Pharm, Program Clin & Expt Therapeut, Augusta, GA 30912 USA.
   [Mbata, Osinakachukwu; El-Remessy, Azza Bahram] Med Coll Georgia, Augusta, GA 30912 USA.
   [Mbata, Osinakachukwu; El-Remessy, Azza Bahram] Univ Georgia Med Partnership, Athens 30606, Greece.
   [El-Magd, Nada Fawzy Abo] Mansoura Univ, Dept Biochem, Fac Pharm, Mansoura 35516, Egypt.
   [El-Remessy, Azza Bahram] Charlie Norwood VA Med Ctr, Augusta Biomed Res Corp, Res Serv Line, Downtown 6B-105, Augusta, GA 30912 USA.
C3 University System of Georgia; University of Georgia; University System
   of Georgia; Augusta University; Egyptian Knowledge Bank (EKB); Mansoura
   University; US Department of Veterans Affairs; Veterans Health
   Administration (VHA); Charlie Norwood VA Medical Center
RP El-Remessy, AB (corresponding author), Charlie Norwood VA Med Ctr, Augusta Biomed Res Corp, Res Serv Line, Downtown 6B-105, Augusta, GA 30912 USA.
EM azza.el-remessy@va.gov
RI Abo El-Magd, Nada/O-5930-2018; El-Remessy, Azza/AAA-3771-2020
OI Fawzy, Nada/0000-0003-2896-2802
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NR 136
TC 49
Z9 61
U1 2
U2 14
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 7041 Koll Center Parkway, Suite 160, PLEASANTON, CA, UNITED STATES
EI 1948-9358
J9 WORLD J DIABETES
JI World J. Diabetes
PD JUL 15
PY 2017
VL 8
IS 7
BP 317
EP 329
DI 10.4239/wjd.v8.i7.317
PG 13
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA FA4MI
UT WOS:000405417000002
PM 28751954
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Khosravi, M
AF Khosravi, Mohsen
TI Biopsychosocial factors associated with disordered eating behaviors in
   schizophrenia
SO ANNALS OF GENERAL PSYCHIATRY
LA English
DT Article
DE Behavior; Eating; Schizophrenia
ID INDUCED WEIGHT-GAIN; ENERGY-EXPENDITURE; ANTIPSYCHOTICS; PREVALENCE;
   ATTITUDES; ANXIETY; OBESITY; PEOPLE
AB Background Recent hypotheses have suggested that schizophrenic patients are more likely to consume unhealthy foods, causing increased rates of mortality and morbidity associated with metabolic syndrome. This raises the need for more in-depth research on disordered eating behaviors (DEBs) in schizophrenic patients. This study, therefore, aimed to investigate biopsychosocial factors associated with DEBs in schizophrenia. Methods In this cross-sectional study, a total of 308 participants (including 83 subjects in the active phase of schizophrenia, 71 subjects in the remission phase of schizophrenia, and 154 control subjects) were recruited through convenience sampling among patients who referred to the Baharan Psychiatric hospital in Zahedan, Iran. Patients were assessed through Eating Attitudes Test (EAT-26), Beck Anxiety Inventory (BAI), Beck Depression Inventory (BDI-II), and Positive and Negative Syndrome Scale (PANSS). Data were analyzed using SPSS v25 software. Further, the statistical significance level was set at p < 0.05. Results The prevalence of DEBs was 41.5% in schizophrenic patients (vs. 10.3% in the control group, p = 0.012). No significant difference was observed in the EAT-26 scores based on gender and phases of schizophrenia. According to multiple linear regression analysis, lack of psychosocial rehabilitation, use of atypical antipsychotics, early stages of psychosis, high level of anxiety and depression, expression of more active psychotic symptoms, tobacco smoking, and suffering from type 2 diabetes were all associated with increased development of DEBs among schizophrenic patients. Conclusions Since the occurrence of DEBs is independent of different phases of schizophrenia, the risk of DEBs is required to be evaluated during the entire course of schizophrenia especially at earlier stages of schizophrenia. Moreover, the use of psychosocial interventions, treatment of affective disorders (i.e., anxiety and depression), antipsychotic medication switching, treatment of tobacco smoking and type 2 diabetes may reduce the risk of DEBs among schizophrenic patients. However, further investigations are required to prove the actual roles of the above factors in developing DEBs among schizophrenic patients.
C1 [Khosravi, Mohsen] Zahedan Univ Med Sci, Baharan Psychiat Hosp, Dept Psychiat & Clin Psychol, Zahedan 9813913777, Iran.
C3 Zahedan University of Medical Sciences
RP Khosravi, M (corresponding author), Zahedan Univ Med Sci, Baharan Psychiat Hosp, Dept Psychiat & Clin Psychol, Zahedan 9813913777, Iran.
EM dr_khosravi2016@yahoo.com
RI khosravi, mohsen/C-8510-2019
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NR 57
TC 18
Z9 18
U1 0
U2 15
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1744-859X
J9 ANN GEN PSYCHIATR
JI Ann. Gen. Psychiatr.
PD DEC 27
PY 2020
VL 19
IS 1
AR 67
DI 10.1186/s12991-020-00314-2
PG 11
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA OX2IA
UT WOS:000593393800001
PM 33292324
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Hernandez-Baixauli, J
   Quesada-Vázquez, S
   Mariné-Casadó, R
   Cardoso, KG
   Caimari, A
   Del Bas, JM
   Escoté, X
   Baselga-Escudero, L
AF Hernandez-Baixauli, Julia
   Quesada-Vazquez, Sergio
   Marine-Casado, Roger
   Gil Cardoso, Katherine
   Caimari, Antoni
   Del Bas, Josep M.
   Escote, Xavier
   Baselga-Escudero, Laura
TI Detection of Early Disease Risk Factors Associated with Metabolic
   Syndrome: A New Era with the NMR Metabolomics Assessment
SO NUTRIENTS
LA English
DT Review
DE metabolic syndrome; metabolism deregulation; molecular biomarker;
   prevention; metabolomics; nutritional habits; carbohydrate dysfunction;
   dyslipidemia; oxidative stress; inflammation; gut microbiota
ID TRIMETHYLAMINE-N-OXIDE; CHAIN AMINO-ACIDS; MIDDLE-AGED MEN;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; URIC-ACID; GUT-MICROBIOTA;
   IN-VIVO; INFLAMMATORY CYTOKINES; PERSONALIZED NUTRITION
AB The metabolic syndrome is a multifactorial disease developed due to accumulation and chronification of several risk factors associated with disrupted metabolism. The early detection of the biomarkers by NMR spectroscopy could be helpful to prevent multifactorial diseases. The exposure of each risk factor can be detected by traditional molecular markers but the current biomarkers have not been enough precise to detect the primary stages of disease. Thus, there is a need to obtain novel molecular markers of pre-disease stages. A promising source of new molecular markers are metabolomics standing out the research of biomarkers in NMR approaches. An increasing number of nutritionists integrate metabolomics into their study design, making nutrimetabolomics one of the most promising avenues for improving personalized nutrition. This review highlight the major five risk factors associated with metabolic syndrome and related diseases including carbohydrate dysfunction, dyslipidemia, oxidative stress, inflammation, and gut microbiota dysbiosis. Together, it is proposed a profile of metabolites of each risk factor obtained from NMR approaches to target them using personalized nutrition, which will improve the quality of life for these patients.
C1 [Hernandez-Baixauli, Julia; Quesada-Vazquez, Sergio; Marine-Casado, Roger; Gil Cardoso, Katherine; Caimari, Antoni; Del Bas, Josep M.; Escote, Xavier; Baselga-Escudero, Laura] Eurecat, Ctr Tecnol Catalunya, Unitat Nutr & Salut, Reus 43204, Spain.
   [Marine-Casado, Roger; Gil Cardoso, Katherine] Univ Rovira & Virgili, Dept Biochem & Biotechnol, Ctra Valls S-N, Tarragona 43007, Spain.
C3 Universitat Rovira i Virgili
RP Escoté, X; Baselga-Escudero, L (corresponding author), Eurecat, Ctr Tecnol Catalunya, Unitat Nutr & Salut, Reus 43204, Spain.
EM julia.hernandez@eurecat.org; sergio.quesada@eurecat.org;
   roger.marine@eurecat.org; katherine.gil@eurecat.org;
   antoni.caimari@eurecat.org; josep.delbas@eurecat.org;
   xavier.escote@eurecat.org; laura.baselga@eurecat.org
RI Escoté, Xavier/AAH-2973-2020; Hernandez-Baixauli, Julia/MGU-3950-2025;
   Quesada Vazquez, Sergio/AHB-6831-2022; del Bas, Josep/K-9310-2019;
   Escote, Xavier/G-3440-2015
OI Quesada Vazquez, Sergio/0000-0001-6588-1193; del Bas, Josep
   Maria/0000-0002-0700-2004; Escote, Xavier/0000-0003-1172-3995; Hernandez
   Baixauli, Julia/0000-0002-9166-4173; Caimari,
   Antoni/0000-0001-6144-0294; Marine-Casado, Roger/0000-0002-0924-4920
FU Catalan Government through grant ACCIO-Eurecat; Centre for the
   Development of Industrial Technology (CDTI) of the Spanish Ministry of
   Science and Innovation [CER-20191010]; European Union [818318]; H2020
   Societal Challenges Programme [818318] Funding Source: H2020 Societal
   Challenges Programme
FX This work was financially supported by the Catalan Government through
   the funding grant ACCIO-Eurecat, by the Centre for the Development of
   Industrial Technology (CDTI) of the Spanish Ministry of Science and
   Innovation under grant agreement: TECNOMIFOOD project CER-20191010 and
   by the European Union's Horizon 2020 Research and Innovation Programme
   under grant agreement: Preventomics projectNo 818318.
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NR 245
TC 37
Z9 39
U1 4
U2 26
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD MAR
PY 2020
VL 12
IS 3
AR 806
DI 10.3390/nu12030806
PG 34
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA LL8VB
UT WOS:000531831000215
PM 32197513
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Haimeur, A
   Ulmann, L
   Mimouni, V
   Guéno, F
   Pineau-Vincent, F
   Meskini, N
   Tremblin, G
AF Haimeur, Adil
   Ulmann, Lionel
   Mimouni, Virginie
   Gueno, Frederique
   Pineau-Vincent, Fabienne
   Meskini, Nadia
   Tremblin, Gerard
TI The role of Odontella aurita, a marine diatom rich in EPA, as a
   dietary supplement in dyslipidemia, platelet function and oxidative
   stress in high-fat fed rats
SO LIPIDS IN HEALTH AND DISEASE
LA English
DT Article
DE Odontella aurita; n-3 PUFA; Platelet aggregation; Metabolic syndrome;
   Oxidative stress
ID PURIFIED EICOSAPENTAENOIC ACID; METABOLIC SYNDROME; FISH-OIL;
   OMEGA-3-FATTY-ACIDS; MICE; ANTIOXIDANT; DISEASE; RISK; ATHEROSCLEROSIS;
   AGGREGATION
AB Background: Dietary changes are a major factor in determining cardiovascular risk. n-3 polyunsaturated fatty acids modulate the risk factors for metabolic syndrome via multiple mechanisms, including the regulation of the lipid metabolism. We therefore investigated the effect of Odontella aurita, a microalga rich in EPA, which is already used as a food supplement, on the risk factors for high-fat diet induced metabolic syndrome in rats.
   Methods: Male Wistar rats were divided into 4 groups and were fed with a standard diet (control); with the standard diet supplemented with 3% freeze-dried O. aurita (COA); with a high-fat diet (HF); or with the high-fat diet supplemented with 3% of freeze-dried O. aurita (HFOA) for 7 weeks. In this study we evaluated the impact of these different diets on the risk factors for metabolic syndrome, such as hyperlipidemia, platelet aggregation, thromboxane B-2 production, and oxidative stress.
   Results: After 7 weeks of treatment, high fat feeding had increased final body weight, glycemia, triacylglycerol, and total cholesterol levels in plasma and liver compared to the control diet. Collagen-induced platelet aggregation and basal platelet thromboxane B-2 were also higher in the high-fat fed rats than in those in the control group. In the liver, oxidative stress was greater in the HF group than in the control group. O. aurita intake in HFOA-fed rats resulted in lower glycemia and lipid levels in the plasma and liver relative than in the HF group. Thus, in the HFOA group, n-3 polyunsaturated fatty acid levels in the tissues studied (plasma, liver, and platelets) were higher than in the HF group. Platelet hyper-aggregability tended to decrease in HFOA-fed rats as basal platelet thromboxane B-2 production decreased. Finally, O. aurita reduced oxidative stress in the liver, with lower malondialdehyde levels and increased glutathione peroxidase activity.
   Conclusions: O. aurita is a marine diatom rich in EPA as well as in other bioactive molecules, such as pigments. The synergistic effect of these microalgal compounds, displayed a beneficial effect in reducing the risk factors for high-fat induced metabolic syndrome: hyperlipidemia, platelet aggregation, and oxidative stress.
C1 [Haimeur, Adil; Ulmann, Lionel; Mimouni, Virginie; Gueno, Frederique; Tremblin, Gerard] Univ Maine, Fac Sci & Tech, Le Mans IUT Dept Genie, PRES LUNAM,EA MMS 657, Laval, France.
   [Haimeur, Adil; Meskini, Nadia] Univ Hassan 2, Lab Biochim Environm & Agroalimentaire, Fac Sci & Tech, Mohammadia, Morocco.
   [Pineau-Vincent, Fabienne] Ctr Hosp Mans, Lab Hemostase, Le Mans, France.
C3 Le Mans Universite; Hassan II University of Casablanca; Centre
   Hospitalier Le Mans
RP Ulmann, L (corresponding author), Univ Maine, Fac Sci & Tech, Le Mans IUT Dept Genie, PRES LUNAM,EA MMS 657, Laval, France.
EM lulman@univ-lemans.fr
RI HAIMEUR, Adil/D-4009-2015; Ulmann, Lionel/AAC-6561-2019
OI Ulmann, Lionel/0000-0002-9009-2791; Mimouni,
   Virginie/0000-0002-2468-0659
FU PHC-Volubilis program [MA/21/61]; French Foreign Affairs Ministry;
   Moroccan Ministry of Research and Higher Education; FP 7 European
   Project GIAVAP (Genetic Improvement of Algae for Value Added Products)
FX The research is supported by the PHC-Volubilis program no MA/21/61 with
   joint financial support from the French Foreign Affairs Ministry and the
   Moroccan Ministry of Research and Higher Education, and by the FP 7
   European Project GIAVAP (Genetic Improvement of Algae for Value Added
   Products).
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NR 60
TC 53
Z9 56
U1 0
U2 50
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1476-511X
J9 LIPIDS HEALTH DIS
JI Lipids Health Dis.
PD OCT 31
PY 2012
VL 11
AR 147
DI 10.1186/1476-511X-11-147
PG 13
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA 076RP
UT WOS:000313975600002
PM 23110391
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Chen, YM
   Zhao, Y
   Feng, LM
   Zhang, J
   Zhang, JW
   Feng, GF
AF Chen, Yimin
   Zhao, Ying
   Feng, Linmin
   Zhang, Jie
   Zhang, Juanwen
   Feng, Guofang
TI Association between alpha-fetoprotein and metabolic syndrome in a
   Chinese asymptomatic population: a cross-sectional study
SO LIPIDS IN HEALTH AND DISEASE
LA English
DT Article
DE Alpha-fetoprotein; Metabolic syndrome; Fatty liver disease
ID CHRONIC HEPATITIS-C; FATTY LIVER; CARDIOVASCULAR EVENTS;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; STEM-CELLS; EXPRESSION;
   REGENERATION; STEATOSIS; OBESITY
AB Background: Metabolic syndrome is closely associated with an increased risk for fatty liver disease morbidity and mortality. Recently, studies have reported that participants with fatty liver disease have higher serum alpha-fetoprotein levels than those without. We investigated the association between alpha-fetoprotein levels and the prevalence of metabolic syndrome in a Chinese asymptomatic population.
   Methods: A cross-sectional study was performed with 7 755 participants who underwent individual health examinations. Clinical and anthropometric parameters were collected and serum alpha-fetoprotein levels and other clinical and laboratory parameters were measured. Logistic regression analysis was used to examine associations between alpha-fetoprotein and metabolic syndrome.
   Results: Participants with metabolic syndrome had significantly higher (p < 0.001) alpha-fetoprotein levels than those without, though all alpha-fetoprotein levels were within the reference interval. The association between the components of metabolic syndrome (central obesity, elevated blood pressure, elevated triglycerides, reduced high-density lipoprotein cholesterol, and elevated fasting plasma glucose) and alpha-fetoprotein levels was evaluated. Alpha-fetoprotein levels in the elevated triglycerides, reduced high-density lipoprotein cholesterol, and elevated fasting plasma glucose groups were significantly different (p = 0.002, p < 0.001, p = 0.020) compared with alpha-fetoprotein in the normal triglycerides, high-density lipoprotein cholesterol, and fasting plasma glucose groups. Logistic regression analyses showed an association between alpha-fetoprotein levels and increased risk for metabolic syndrome, the presence of reduced high-density lipoprotein cholesterol, and elevated fasting plasma glucose, but not with obesity, elevated blood pressure, or triglycerides.
   Conclusions: These results suggest a significant association between alpha-fetoprotein and metabolic syndrome.
C1 [Chen, Yimin] Zhejiang Chinese Med Univ, Affiliated Hosp 1, Zhejiang Prov Hosp Tradit Chinese Med, Dept Clin Lab, Youdian Rd 54, Hangzhou 310006, Zhejiang, Peoples R China.
   [Zhao, Ying; Feng, Linmin; Zhang, Jie; Zhang, Juanwen] Zhejiang Univ, Sch Med, Affiliated Hosp 1, Dept Clin Lab, Qingchun Rd 79, Hangzhou 310003, Zhejiang, Peoples R China.
   [Feng, Guofang] Zhejiang Univ, Sch Med, Affiliated Womens Hosp, Xueshi Rd 1, Hangzhou 310006, Zhejiang, Peoples R China.
C3 Zhejiang Chinese Medical University; Zhejiang University; Zhejiang
   University
RP Feng, GF (corresponding author), Zhejiang Univ, Sch Med, Affiliated Womens Hosp, Xueshi Rd 1, Hangzhou 310006, Zhejiang, Peoples R China.
EM FBFGF2@126.com
RI Chen, Yimin/P-6574-2017; Feng, Guofang/KVB-5336-2024
FU Zhejiang Provincial Natural Science Foundation of China [LY15H190002];
   Science Foundations of Health Bureau of Zhejiang Province [2013KYB116,
   2014KYA252]
FX This work was financially supported by grants from the Zhejiang
   Provincial Natural Science Foundation of China (LY15H190002) and the
   Science Foundations of Health Bureau of Zhejiang Province (2013KYB116
   and 2014KYA252).
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NR 47
TC 19
Z9 22
U1 0
U2 5
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1476-511X
J9 LIPIDS HEALTH DIS
JI Lipids Health Dis.
PD APR 27
PY 2016
VL 15
AR 85
DI 10.1186/s12944-016-0256-x
PG 9
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA DK5DS
UT WOS:000374940500002
PM 27121855
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Hung, WC
   Wu, JS
   Sun, ZJ
   Lu, FH
   Yang, YC
   Chang, CJ
AF Hung, Wei-Chieh
   Wu, Jin-Shang
   Sun, Zih-Jie
   Lu, Feng-Hwa
   Yang, Yi-Ching
   Chang, Chih-Jen
TI Gender differences in the association of non-alcoholic fatty liver
   disease and metabolic syndrome with erosive oesophagitis: a
   cross-sectional study in a Taiwanese population
SO BMJ OPEN
LA English
DT Article
ID GASTROESOPHAGEAL-REFLUX DISEASE; RISK-FACTORS; ENDOSCOPIC ASSESSMENT;
   OXIDATIVE STRESS; OBESITY; PREDOMINANCE; FIBROSIS; DEFINE; HEALTH; ACID
AB Objectives: Although metabolic syndrome correlates with erosive oesophagitis, few studies have examined the association between nonalcoholic fatty liver disease (NAFLD), associated with obesity and insulin resistance as metabolic syndrome, and erosive oesophagitis. The possible gender differences in risk factors of erosive oesophagitis should be considered. This study aimed to determine the concomitant effects of NAFLD and metabolic syndrome on erosive oesophagitis with respect to gender.
   Design, setting, participants and outcome measures: This cross-sectional study, conducted between January 2000 and August 2009, included 12 090 participants from the health examination center of a tertiary hospital. NAFLD was diagnosed according to ultrasonographic findings after excluding participants with excessive alcohol consumption or other liver diseases. Metabolic syndrome was determined using the revised National Cholesterol Education Program Adult Treatment Panel III criteria. Erosive oesophagitis was defined according to the Los Angeles classification by oesophagogastroduodenoscopy.
   Results: On the basis of the oesophagogastroduodenoscopic findings, the prevalence of erosive oesophagitis was 20.1% (n=1427/7110) and 9.9% (n=477/4842) in males and females, respectively. After adjusting for other variables, metabolic syndrome (OR 1.26; 95% CI 1.09 to 1.45) but not NAFLD (OR 1.14; 95% CI 0.98 to 1.30) significantly correlated with erosive oesophagitis in males, while NAFLD (OR 1.50; 95% CI 1.21 to 1.86) but not metabolic syndrome (OR 1.24; 95% CI 0.94 to 1.63) positively correlated with erosive oesophagitis in females.
   Conclusions: The detrimental effect on erosive oesophagitis is greater by metabolic syndrome than by NAFLD in males but greater by NAFLD than by metabolic syndrome in females.
C1 [Hung, Wei-Chieh] I Shou Univ, E Da Hosp, Dept Family Med, Kaohsiung, Taiwan.
   [Hung, Wei-Chieh; Wu, Jin-Shang; Lu, Feng-Hwa; Yang, Yi-Ching; Chang, Chih-Jen] Natl Cheng Kung Univ Hosp, Dept Family Med, Tainan, Taiwan.
   [Wu, Jin-Shang; Lu, Feng-Hwa; Yang, Yi-Ching; Chang, Chih-Jen] Natl Cheng Kung Univ, Coll Med, Dept Family Med, Tainan, Taiwan.
   [Sun, Zih-Jie] Natl Cheng Kung Univ, Coll Med & Hosp, Dou Liou Branch, Dept Family Med, Tainan 701, Yunlin, Taiwan.
   [Sun, Zih-Jie] Natl Cheng Kung Univ, Coll Med, Inst Gerontol, Tainan, Taiwan.
C3 E-Da Hospital; I Shou University; National Cheng Kung University;
   National Cheng Kung University Hospital; National Cheng Kung University;
   National Cheng Kung University; National Cheng Kung University
RP Chang, CJ (corresponding author), Natl Cheng Kung Univ Hosp, Dept Family Med, Tainan, Taiwan.
EM changcj.ncku@gmail.com
RI Chen, Yun-Yu/IXO-3895-2023
OI Hung, Wei Chieh/0000-0002-5163-8712
FU Department of Family Medicine, National Cheng-Kung University Hospital,
   Taiwan [NCKUHFM-101-003]; E-Da hospital
FX This study was supported by the Department of Family Medicine, National
   Cheng-Kung University Hospital, Taiwan (grant number NCKUHFM-101-003)
   and E-Da hospital.
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NR 41
TC 8
Z9 8
U1 0
U2 2
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2044-6055
J9 BMJ OPEN
JI BMJ Open
PY 2016
VL 6
IS 11
AR e013106
DI 10.1136/bmjopen-2016-013106
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA EG8JQ
UT WOS:000391303400085
PM 27852719
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Magdy, YM
   El-Kharashi, OA
   Nabih, ES
   Shaker, SM
   Abd-Elaziz, LF
   Aboul-Fotouh, S
AF Magdy, Yosra M.
   El-Kharashi, Omnyah A.
   Nabih, Enas S.
   Shaker, Safaa M.
   Abd-Elaziz, Lobna F.
   Aboul-Fotouh, Sawsan
TI Potential involvement of JNK1 repression in the hepatic effect of
   sitagliptin and metformin in rats subjected to high fat diet and chronic
   mild distress
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Article
DE Behavior; Chronic restraint stress; Depression; JNK; Metformin; NASH;
   Rat; Sitagliptin
ID DIPEPTIDYL PEPTIDASE-4 INHIBITOR; ANTIDEPRESSANT-LIKE ACTIVITY;
   DEPRESSIVE-LIKE BEHAVIOR; INSULIN-RESISTANT RATS; N-TERMINAL KINASE;
   LIVER-DISEASE; NONALCOHOLIC STEATOHEPATITIS; C-JUN; METABOLIC SYNDROME;
   DEFICIENT MICE
AB Background: Depression and non-alcoholic steatohepatitis (NASH) are highly co-morbid, and hepatic JNK pathway may be involved in their relation. Aim: To evaluate the impact of depression on NASH through the involvement of JNK1 and to assess the effect of sitagliptin and metformin on hepatic JNK1 expression in both NASH and NASH associated with depression.
   Methods: Eight groups of male Wistar rats were used: naive rats, non-stressed NASH, non-stressed NASH sitagliptin treated, non-stressed NASH metformin treated, stressed, stressed NASH untreated, stressed NASH sitagliptin treated and stressed NASH metformin treated. Behavioral, biochemical, molecular and histopathological studies were performed.
   Results: Non-stressed NASH group showed depressive like symptoms, disturbed glucose homeostasis, impairment of liver functions, decrease adiponectin and increase malondialdehyde, which were aggreviated by stress. Sitagliptin produced significant improvement compared to metformin regarding biochemical and histopathological parameters. Furthermore, sitagliptin significantly decreased expression of hepatic JNK1 in both stressed and non-stressed rats. All these changes were accompanied by significant improvement of behavioral changes.
   Conclusions: The link between NASH and depression raised the role of JNK activation through increase expression of JNK1. Since sitagliptin was associated with preferable effects than metformin, therefore, it is potentially preferred in the management of either NASH or NASH associated with depression. (C) 2016 Elsevier Masson SAS. All rights reserved.
C1 [Magdy, Yosra M.; El-Kharashi, Omnyah A.; Abd-Elaziz, Lobna F.; Aboul-Fotouh, Sawsan] Ain Shams Univ, Dept Pharmacol, Fac Med, Cairo, Egypt.
   [Nabih, Enas S.] Ain Shams Univ, Dept Med Biochem, Fac Med, Cairo, Egypt.
   [Shaker, Safaa M.] Ain Shams Univ, Dept Histol, Fac Med, Cairo, Egypt.
C3 Egyptian Knowledge Bank (EKB); Ain Shams University; Egyptian Knowledge
   Bank (EKB); Ain Shams University; Egyptian Knowledge Bank (EKB); Ain
   Shams University
RP Nabih, ES (corresponding author), Ain Shams Univ, Dept Med Biochem, Fac Med, Cairo, Egypt.
EM y_yosra@hotmail.com; omnyah2011@gmail.com; enassamer@hotmail.com;
   safashalaby@yahoo.com; lobna-pharma@hotmail.com; sawsanaf2005@yahoo.com
OI magdy, yosra/0000-0002-1226-3057
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NR 70
TC 13
Z9 13
U1 2
U2 22
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD JAN
PY 2017
VL 85
BP 225
EP 238
DI 10.1016/j.biopha.2016.10.098
PG 14
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA EM7WK
UT WOS:000395522800027
PM 27916420
DA 2025-06-11
ER

PT J
AU Moreno, JA
   Hong, E
AF Moreno, J. A.
   Hong, E.
TI A single oral dose of fructose induces some features of metabolic
   syndrome in rats: Role of oxidative stress
SO NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
LA English
DT Article
DE Fructose-induced hypertension; Oxidative stress; Metabolic syndrome
ID SYMPATHETIC-NERVE ACTIVITY; INSULIN SENSITIVITY; GLUCOSE-UPTAKE;
   URIC-ACID; HYPERTENSION; RESISTANCE; LIVER; DIET
AB Background and aims: To determine if a single oral dose of fructose to rats reproduces some features of metabolic syndrome observed after chronic administration and if so, to investigate its mechanisms.
   Methods and results: Systolic blood pressure was measured in rats before and after oral administration of fructose, and in animals pretreated with lipoic acid, methyldopa, losartan or streptozotocin. In other rats, glucose, insulin, uric acid, and insulin sensitivity index, were determined before and after fructose or lipoic acid plus fructose. Glutathione was measured in liver before and after fructose administration. In aortic rings from other rats, incubation with mannitol, fructose, or fructose plus lipoic acid was evaluated on the relaxation by acetylcholine. Fructose produced a moderate increase in blood pressure, which was prevented by lipoic acid or streptozotocin. Methyldopa and losartan decreased the pressor response minimally. Fructose increased oxidized glutathione, plasma glucose, insulin and uric acid, and diminished the insulin sensitivity index, and the reduced glutathione. Lipoic acid prevented hyperglycemia and hyperuricemia, and improved the insulin sensitivity index. Finally, endothelial dysfunction was prevented by lipoic acid.
   Conclusion: A single dose of fructose reproduces some of the features of metabolic syndrome, most changes were caused by oxidative stress and insulin resistance. (C) 2011 Elsevier B.V. All rights reserved.
C1 [Moreno, J. A.] UNAM, Fac Med, Coyoacan Df 04510, Mexico.
   [Moreno, J. A.; Hong, E.] CINVESTAV IPN, Dept Pharmacobiol, Granjas Coapa 14330, Tlalpan Df, Mexico.
C3 Universidad Nacional Autonoma de Mexico; CINVESTAV - Centro de
   Investigacion y de Estudios Avanzados del Instituto Politecnico Nacional
RP Hong, E (corresponding author), CINVESTAV IPN, Dept Pharmacobiol, Calzada Tenorios 235, Granjas Coapa 14330, Tlalpan Df, Mexico.
EM acuarioauro@hotmail.com; ehong@cinvestav.mx
RI Moreno-Munoz, J.A,/AAG-2230-2020
FU ICYTDF [PICDS 08-24]
FX This work constitutes a requirement to obtain the DSc Degree of JAM at
   UNAM, School of Medicine. It was partially supported by PICDS 08-24 from
   the ICYTDF. Thanks to Gerardo Rivera and coworkers by their technical
   help.
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NR 27
TC 19
Z9 21
U1 0
U2 25
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0939-4753
EI 1590-3729
J9 NUTR METAB CARDIOVAS
JI Nutr. Metab. Carbiovasc. Dis.
PD JUN
PY 2013
VL 23
IS 6
BP 536
EP 542
DI 10.1016/j.numecd.2011.10.008
PG 7
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism; Nutrition
   & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism;
   Nutrition & Dietetics
GA 167QE
UT WOS:000320646000009
PM 22386006
DA 2025-06-11
ER

PT J
AU Chockalingam, A
   Linden, MA
   Del Rosario, M
   Govindarajan, G
   Dellsperger, KC
   Thomas, TR
AF Chockalingam, Anand
   Linden, Melissa A.
   Del Rosario, Marc
   Govindarajan, Gurushankar
   Dellsperger, Kevin C.
   Thomas, Tom R.
TI Exercise and Weight Loss Improve Exercise Capacity Independent of
   Cardiac Function in Metabolic Syndrome
SO ANGIOLOGY
LA English
DT Article
DE metabolic syndrome; diastolic function; weight loss; exercise capacity;
   lifestyle changes; E/E '
ID DIASTOLIC HEART-FAILURE; VENTRICULAR EJECTION FRACTION;
   DOPPLER-ECHOCARDIOGRAPHY; STRESS ECHOCARDIOGRAPHY; FILLING PRESSURE;
   DYSFUNCTION; COMMUNITY; VELOCITY
AB Hypertension, diabetes and obesity cause cardiac diastolic dysfunction (DD) which could reduce exercise capacity. Our aim was to determine if 10% weight loss by exercise at 60% VO(2max) five days/week (similar to-375 kcal/session) and caloric restriction (similar to-600 kcal/d) over 6 months improves exercise capacity and DD in Metabolic syndrome (MetS). Eighteen subjects (40 +/- 1y, women = 6, BMI = 33.5 +/- 1.0 kg/m(2)) successfully completed the study. Maximal treadmill stress echocardiography was performed at baseline and post weight loss to determine VO(2max), resting and stress DD as the ratio of peak early diastolic mitral inflow velocity (E) to tissue Doppler early diastolic annular decent (E'). After weight loss (mean = 9.5 +/- 0.2%), all metabolic parameters improved. Resting and stress E/E' values remained normal before and after weight loss. Exercise intolerance is likely due to general deconditioning and not cardiac dysfunction in early MetS as VO(2max) increases significantly with lifestyle while cardiac function remains unchanged.
C1 [Chockalingam, Anand; Del Rosario, Marc; Govindarajan, Gurushankar; Dellsperger, Kevin C.] Univ Missouri, Div Cardiol, Dept Internal Med, Columbia, MO 65212 USA.
   [Linden, Melissa A.; Thomas, Tom R.] Univ Missouri, Dept Nutr & Exercise Physiol, Columbia, MO 65212 USA.
   [Chockalingam, Anand] Harry S Truman VA Med Ctr, Cardiol Sect, Columbia, MO USA.
C3 University of Missouri System; University of Missouri Columbia;
   University of Missouri System; University of Missouri Columbia; US
   Department of Veterans Affairs; Veterans Health Administration (VHA);
   Harry S. Truman Memorial Veterans' Hospital
RP Chockalingam, A (corresponding author), Univ Missouri, Div Cardiol, Dept Internal Med, 5 Hosp Dr,CE306, Columbia, MO 65212 USA.
EM chockalingama@health.missouri.edu
RI Linden, Melissa/P-3079-2017
OI Linden, Melissa/0000-0002-3152-0864; Chockalingam,
   Anand/0000-0002-4502-1759
FU VISN 15 Veterans Administration; NIH [R01 DK067036]
FX This study is supported by VISN 15 Veterans Administration Research
   award to A Chockalingam and NIH R01 DK067036 to TR Thomas.
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NR 26
TC 11
Z9 11
U1 0
U2 4
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0003-3197
J9 ANGIOLOGY
JI Angiology
PD FEB
PY 2010
VL 61
IS 2
BP 192
EP 197
DI 10.1177/0003319709336418
PG 6
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 549DP
UT WOS:000274024100010
PM 20118106
DA 2025-06-11
ER

PT J
AU Fernández-Garcia, JC
   Cardona, F
   Tinahones, FJ
AF Fernandez-Garcia, Jose C.
   Cardona, Fernando
   Tinahones, Francisco J.
TI Inflammation, Oxidative Stress and Metabolic Syndrome: Dietary
   Modulation
SO CURRENT VASCULAR PHARMACOLOGY
LA English
DT Article
DE Dietary modulation; inflammation; mediterranean diet; metabolic
   syndrome; oxidative stress; polyphenols; resveratrol
ID TUMOR-NECROSIS-FACTOR; FATTY-ACID-COMPOSITION; FACTOR-KAPPA-B; INDUCED
   INSULIN-RESISTANCE; LOW-DENSITY-LIPOPROTEIN; ALPHA-LIPOIC ACID; MONOCYTE
   CHEMOATTRACTANT PROTEIN-1; VITAMIN-C SUPPLEMENTATION; TYPE-2
   DIABETES-MELLITUS; MEDITERRANEAN DIET
AB The metabolic syndrome (MetS) is a cluster of risk factors for the development of cardiovascular disease and type 2 diabetes mellitus. These risk factors include raised blood pressure, dyslipidemia (raised triglycerides and lowered high-density lipoprotein cholesterol), raised fasting glucose, and central obesity. MetS has become a serious public health and clinical problem whose prevalence and incidence are increasing along with the worldwide rise in rates of obesity and sedentary lifestyles. A number of studies have shown that MetS is associated with a state of low-grade inflammation, characterized by abnormal pro-inflammatory cytokine production, increased acute-phase reactants, and activation of a network of inflammatory signalling pathways. Moreover, MetS has also been linked to oxidative stress, a consequence of a reduction in the antioxidant systems and an increase in the production of reactive oxygen species. Nevertheless, agreement exists that dietary intervention may modulate the pro-inflammatory state and lessen oxidative stress related to MetS, thereby decreasing the cardiovascular risk. In this review we address the current available evidence regarding dietary modulation of inflammation and oxidative stress associated with MetS.
C1 [Fernandez-Garcia, Jose C.; Tinahones, Francisco J.] Virgen Victoria Univ Hosp, Dept Endocrinol, Malaga 29010, Spain.
   [Cardona, Fernando] Virgen Victoria Univ Hosp, Res Lab, Malaga 29010, Spain.
   [Fernandez-Garcia, Jose C.; Cardona, Fernando; Tinahones, Francisco J.] Inst Salud Carlos III, Spanish Biomed Res Ctr Physiopathol Obes & Nutr C, Madrid, Spain.
C3 Instituto de Salud Carlos III
RP Fernández-Garcia, JC (corresponding author), Virgen Victoria Univ Hosp, Dept Endocrinol, Campus Teatinos S-N, Malaga 29010, Spain.
EM josecarlosfdezgarcia@hotmail.com
RI Tinahones, Francisco/AAB-2882-2020; Cardona, Fernando/AAG-7835-2019;
   Fernandez-Garcia, Jose Carlos/B-5312-2013; Cardona, Fernando/H-6022-2015
OI Fernandez-Garcia, Jose Carlos/0000-0003-2229-8488; Cardona,
   Fernando/0000-0003-4460-6824; Tinahones, Francisco J/0000-0001-6871-4403
FU "Instituto de Salud Carlos III", Madrid, Spain [CM12/00059]; Spanish
   Ministry of Health [CP07/00095]
FX We thank Ian Johnstone for English language editing. Jose C.
   Fernandez-Garcia is recipient of a "Rio Hortega" contract from
   "Instituto de Salud Carlos III", Madrid, Spain (CM12/00059). Fernando
   Cardona is a recipient of a post-doctoral grant "Miguel Servet" from the
   Spanish Ministry of Health (CP07/00095).
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NR 197
TC 51
Z9 53
U1 0
U2 30
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1570-1611
EI 1875-6212
J9 CURR VASC PHARMACOL
JI Current Vascular Pharmacology
PD NOV
PY 2013
VL 11
IS 6
BP 906
EP 919
DI 10.2174/15701611113116660175
PG 14
WC Pharmacology & Pharmacy; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Cardiovascular System & Cardiology
GA AA4IC
UT WOS:000331058300010
PM 24168441
DA 2025-06-11
ER

PT J
AU Mostafa, DK
   Nasra, RA
   Zahran, N
   Ghoneim, MT
AF Mostafa, Dalia K.
   Nasra, Rasha A.
   Zahran, Noha
   Ghoneim, Mohammed T.
TI Pleiotropic protective effects of Vitamin D against high fat
   diet-induced metabolic syndrome in rats: One for all
SO EUROPEAN JOURNAL OF PHARMACOLOGY
LA English
DT Article
DE Vitamin D; Metabolic syndrome; Metformin; Insulin resistance;
   Hypertension
ID 25-HYDROXYVITAMIN D DEFICIENCY; RECEPTOR GENE POLYMORPHISMS;
   INSULIN-RESISTANCE; 1,25-DIHYDROXYVITAMIN D-3; INFLAMMATION; DISEASE;
   OBESITY; SUPPLEMENTATION; ASSOCIATION; EXPRESSION
AB Several lines of evidence point to the association of vitamin D deficiency with the different components of metabolic syndrome. Yet, the effect of vitamin D supplementation on metabolic syndrome is not clearly elucidated. Herein, we tested the hypothesis that administration of vitamin D, either alone or in combination of metformin can improve metabolic and structural derangements associated with metabolic syndrome. Fifty wistar rats were randomly assigned to serve either as normal control (10 rats) or metabolic syndrome rats, by feeding them with a standard or a high fat diet (HFD), respectively. Metabolic syndrome rats were further assigned to receive either vehicle, Metformin (100 mg/Kg orally), vitamin D (6 ng/Kg SC.) or both, daily for 8 weeks. Body weight, blood pressure, serum glucose, insulin, insulin resistance, lipid profile, oxidative stress, serum uric acid and Ca+2 were assessed at the end of the study. Histopathological examination of hepatic, renal and cardiac tissues were also performed. Treatment with vitamin D was associated with a significant improvement of the key features of metabolic syndrome namely obesity, hypertension and dyslipidaemia with a neutral effect on Ca+2 level. When combined with metformin, most of the other metabolic abnormalities were ameliorated. Furthermore, a significant attenuation of the associated hepatic steatosis was observed with vitamin D as well as vitamin D/metformin combination. In conclusion, vitamin D can improve hypertension, metabolic and structural abnormalities induced by HFD, and it provides additional benefits when combined with metformin. Therefore, vitamin D could represent a feasible therapeutic option for prevention of metabolic syndrome.
C1 [Mostafa, Dalia K.; Ghoneim, Mohammed T.] Univ Alexandria, Dept Clin Pharmacol, Fac Med, Alexandria, Egypt.
   [Nasra, Rasha A.] Univ Alexandria, Dept Biochem, Fac Med, Alexandria, Egypt.
   [Zahran, Noha] Univ Alexandria, Dept Histol & Cellular Biol, Fac Med, Alexandria, Egypt.
C3 Egyptian Knowledge Bank (EKB); Alexandria University; Egyptian Knowledge
   Bank (EKB); Alexandria University; Egyptian Knowledge Bank (EKB);
   Alexandria University
RP Mostafa, DK (corresponding author), Fac Med, Dept Clin Pharmacol, Almoassat Med Campus, Alexandria, Egypt.
EM dalia.kashishy@alexmed.edu.eg
RI Mostafa, Dalia/AAL-9118-2021; Nassra, Rasha/AGN-8484-2022
OI Nassra, Rasha/0000-0002-7642-8009; zahran, noha/0000-0002-3988-2587;
   Mostafa, Dalia Kamal/0000-0002-5057-2491
FU Alexandria University Award
FX This work is partially supported by Alexandria University Award.
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NR 56
TC 17
Z9 20
U1 0
U2 19
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0014-2999
EI 1879-0712
J9 EUR J PHARMACOL
JI Eur. J. Pharmacol.
PD DEC 5
PY 2016
VL 792
BP 38
EP 47
DI 10.1016/j.ejphar.2016.10.031
PG 10
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA EF9JG
UT WOS:000390645900006
PM 27789220
DA 2025-06-11
ER

PT J
AU Monserrat-Mesquida, M
   Quetglas-Llabrés, M
   Capó, X
   Bouzas, C
   Mateos, D
   Pons, A
   Tur, JA
   Sureda, A
AF Monserrat-Mesquida, Margalida
   Quetglas-Llabres, Magdalena
   Capo, Xavier
   Bouzas, Cristina
   Mateos, David
   Pons, Antoni
   Tur, Josep A.
   Sureda, Antoni
TI Metabolic Syndrome Is Associated with Oxidative Stress and
   Proinflammatory State
SO ANTIOXIDANTS
LA English
DT Article
DE metabolic syndrome; oxidative stress; cytokine; inflammation; PBMCs
ID DIABETES-MELLITUS; MONONUCLEAR-CELLS; INFLAMMATION; OBESITY;
   ANTIOXIDANTS; PREVALENCE; COUNT
AB Metabolic syndrome (MetS) is associated with increased risk of developing diabetes and cardiovascular diseases. MetS is also characterized by an increase of oxidative stress which contributes to impaired inflammation, vascular function, and atherosclerosis. The aim was to assess the oxidative stress and inflammatory markers in plasma and PBMCs in adults with or without MetS. Antioxidant and inflammatory parameters were measured in peripheral blood mononuclear cells (PBMCs) of 80 men and 80 women over 55 to 80-years-old residing in the Balearic Islands without previously documented cardiovascular disease. Circulating leukocytes, neutrophils, lymphocytes, basophils, and monocytes were higher in MetS subjects with respect to those without MetS. Plasma levels of malondialdehyde, tumor necrosis factor alpha (TNF alpha), and interleukin 6 (IL-6) levels were higher in MetS subjects in both genders, but the superoxide dismutase activity was lower. The myeloperoxidase plasma activity was higher in the MetS male subjects. Higher activities and protein levels of catalase and glutathione reductase in PBMCs were observed in MetS subjects in both genders. Obtained data show that MetS is associated with oxidative stress and a proinflammatory state and with high antioxidant defenses in PBMCs probably derived from a pre-activation state of immune cells.
C1 [Monserrat-Mesquida, Margalida; Quetglas-Llabres, Magdalena; Capo, Xavier; Bouzas, Cristina; Mateos, David; Pons, Antoni; Tur, Josep A.; Sureda, Antoni] Univ Balearic Isl, Hlth Res Inst Balearic Isl IdISBa, Res Grp Community Nutr & Oxidat Stress, E-07122 Palma De Mallorca, Balearic Island, Spain.
   [Monserrat-Mesquida, Margalida; Quetglas-Llabres, Magdalena; Capo, Xavier; Bouzas, Cristina; Mateos, David; Pons, Antoni; Tur, Josep A.; Sureda, Antoni] CIBEROBN Physiopathol Obes & Nutr, E-07122 Palma De Mallorca, Balearic Island, Spain.
C3 Institut Investigacio Sanitaria Illes Balears (IdISBa); Universitat de
   les Illes Balears; CIBER - Centro de Investigacion Biomedica en Red;
   CIBEROBN
RP Tur, JA (corresponding author), Univ Balearic Isl, Hlth Res Inst Balearic Isl IdISBa, Res Grp Community Nutr & Oxidat Stress, E-07122 Palma De Mallorca, Balearic Island, Spain.
EM margalida.monserrat@uib.es; m.quetglas@uib.es; xavier.capo@uib.es;
   cristinabouvel@gmail.com; davidfrom13@gmail.com; antonipons@uib.es;
   pep.tur@uib.es; antoni.sureda@uib.es
RI Capó, Xavier/AAD-6322-2022; Mateos, David/N-7366-2018; Tur,
   Josep/AAE-5748-2020; Sureda, Antoni/N-9588-2019; Mesquida,
   Margalida/AAB-4773-2019; Bouzas, Cristina/AAE-2069-2019; Quetglas
   Llabrés, Maria/AAA-4412-2019; Tur, Josep/F-5576-2014; Pons,
   Antoni/L-4844-2014
OI Monserrat Mesquida, Margalida/0000-0002-8856-135X; ,
   Antoni/0000-0001-8656-6838; Bouzas Velasco,
   Cristina/0000-0002-1407-8461; Capo Fiol, Xavier/0000-0002-3499-5494;
   Tur, Josep/0000-0002-6940-0761; Quetglas Llabres, Maria
   Magdalena/0000-0003-4155-7780; Pons, Antoni/0000-0003-2447-3868
FU Instituto de Salud Carlos III through the Fondo de Investigacion para la
   Salud (FIS) - European Regional Development Fund [PI14/00636,
   PI17/01827, Red Predimed-RETIC RD06/0045/1004, CIBEROBN CB12/03/30038];
   EU-COST Action [CA16112]; Balearic Islands Gov. [35/2011, 23/2012];
   IDISBA Grant (FOLIUM); IDISBA Grant (PRIMUS); IDISBA Grant (SYNERGIA);
   IDISBA Grant (LIBERI); Fundacio La Marato TV3 (Spain) project
   [201630.10]; SOIB Program for Qualified Young People; Fernando Tarongi
   Bauza PhD Grant
FX Instituto de Salud Carlos III through the Fondo de Investigacion para la
   Salud (FIS), which is cofunded by the European Regional Development Fund
   (Projects PI14/00636 and PI17/01827, Red Predimed-RETIC RD06/0045/1004,
   and CIBEROBN CB12/03/30038), EU-COST Action CA16112; Grant of support to
   research groups no. 35/2011 and 23/2012 (Balearic Islands Gov.), IDISBA
   Grants (FOLIUM, PRIMUS, SYNERGIA, and LIBERI), and Fundacio La Marato
   TV3 (Spain) project ref. 201630.10. M.Q.-LL. was granted by SOIB Program
   for Qualified Young People. C.B. received a Fernando Tarongi Bauza PhD
   Grant. The funding sponsors had no role in the design of the study, in
   the collection, analyses, or interpretation of the data; in the writing
   of the manuscript, or in the decision to publish the results.
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NR 59
TC 130
Z9 134
U1 1
U2 17
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD MAR
PY 2020
VL 9
IS 3
AR 236
DI 10.3390/antiox9030236
PG 14
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA LB2UG
UT WOS:000524490700041
PM 32178436
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Hsieh, CC
   Liao, CC
   Liao, YC
   Hwang, LS
   Wu, LY
   Hsieh, SC
AF Hsieh, Cheng-Chu
   Liao, Chen-Chung
   Liao, Yi-Chun
   Hwang, Lucy Sun
   Wu, Liang-Yi
   Hsieh, Shu-Chen
TI Proteomic changes associated with metabolic syndrome in a fructose-fed
   rat model
SO JOURNAL OF FOOD AND DRUG ANALYSIS
LA English
DT Article
DE endoplasmic reticulum stress; fructose; insulin resistance; metabolic
   syndrome; oxidative stress
ID INSULIN-RESISTANCE; OXIDATIVE STRESS; ADIPOSE-TISSUE; RHO-GTPASES;
   CANCER; MICE; EXPRESSION; OBESITY; HYPERINSULINEMIA; PEROXIREDOXINS
AB Metabolic syndrome (MetS), characterized by a constellation of disorders such as hyperglycemia, insulin resistance, and hypertension, is becoming a major global public health problem. Fructose consumption has increased dramatically over the past several decades and with it the incidence of MetS. However, its molecular mechanisms remain to be explored. In this study, we used male Sprague-Dawley (SD) rats to study the pathological mechanism of fructose induced MetS. The SD rats were fed a 60% high-fructose diet for 16 weeks to induce MetS. The induction of MetS was confirmed by blood biochemistry examination. Proteomics were used to investigate the differential hepatic protein expression patterns between the normal group and the MetS group. Proteomic results revealed that fructose-induced MetS induced changes in glucose and fatty acid metabolic pathways. In addition, oxidative stress and endoplasmic reticulum stress-related proteins were modulated by high-fructose feeding. In summary, our results identify many new targets for future investigation. Further characterization of these proteins and their involvement in the link between insulin resistance and metabolic dyslipidemia may bring new insights into MetS. Copyright (C) 2016, Food and Drug Administration, Taiwan. Published by Elsevier Taiwan LLC.
C1 [Hsieh, Cheng-Chu] Natl Taiwan Univ, Sch Vet Med, Dept & Inst Vet Med, Taipei, Taiwan.
   [Hsieh, Cheng-Chu] Council Agr, Anim Hlth Res Inst, Div Biol, New Taipei, Taiwan.
   [Liao, Chen-Chung] Natl Yang Ming Univ, Prote Res Ctr, Taipei, Taiwan.
   [Liao, Yi-Chun] Natl Taiwan Univ, Dept Biochem Sci & Technol, Taipei, Taiwan.
   [Hwang, Lucy Sun; Hsieh, Shu-Chen] Natl Taiwan Univ, Inst Food Sci & Technol, Taipei, Taiwan.
   [Wu, Liang-Yi] Chung Yuan Christian Univ, Dept Biosci Technol, Taoyuan, Taiwan.
C3 National Taiwan University; National Yang Ming Chiao Tung University;
   National Taiwan University; National Taiwan University; Chung Yuan
   Christian University
RP Hsieh, SC (corresponding author), Natl Taiwan Univ, Inst Food Sci & Technol, Coll Bioresources & Agr, 1,Sect 4,Roosevelt Rd, Taipei 10617, Taiwan.
EM schsieh@ntu.edu.tw
RI Hung, Kun-Che/AAG-8074-2021; chen, chen/GRY-7085-2022; Li,
   Jenny/GSD-3780-2022; Liao, Yi-Chun/H-2383-2014
OI Liao, Yi-Chun/0000-0002-0399-0201; HSIEH, SHU-CHEN/0000-0002-0844-7435
FU National Science Council, Taipei City, Taiwan, Republic of China [NSC
   98-2313-B002-064]
FX This work was financially supported by Grants NSC 98-2313-B002-064 from
   the National Science Council, Taipei City, Taiwan, Republic of China.
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NR 36
TC 23
Z9 24
U1 0
U2 9
PU FOOD & DRUG ADMINSTRATION
PI TAIPEI
PA 161-2 KUNYANG STREET, NANGANG, TAIPEI, 00000, TAIWAN
SN 1021-9498
J9 J FOOD DRUG ANAL
JI J. Food Drug Anal.
PD OCT
PY 2016
VL 24
IS 4
BP 754
EP 761
DI 10.1016/j.jfda.2016.03.005
PG 8
WC Food Science & Technology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Pharmacology & Pharmacy
GA EC2JD
UT WOS:000387937100010
PM 28911613
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Patanè, GT
   Putaggio, S
   Tellone, E
   Barreca, D
   Ficarra, S
   Maffei, C
   Calderaro, A
   Laganà, G
AF Patane, Giuseppe Tancredi
   Putaggio, Stefano
   Tellone, Ester
   Barreca, Davide
   Ficarra, Silvana
   Maffei, Carlo
   Calderaro, Antonella
   Lagana, Giuseppina
TI Catechins and Proanthocyanidins Involvement in Metabolic Syndrome
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE cardiovascular diseases; natural antioxidants; inflammatory state;
   flavan-3-ols; catechins; proanthocyanidins
ID HUMAN SERUM-ALBUMIN; GREEN TEA POLYPHENOL; NF-KAPPA-B; NITRIC-OXIDE
   SYNTHASE; INSULIN-RESISTANCE; OXIDATIVE STRESS; EPIGALLOCATECHIN
   GALLATE; MITOCHONDRIAL DYSFUNCTION; LIPID-PEROXIDATION; RISK-FACTORS
AB Recent studies on natural antioxidant compounds have highlighted their potentiality against various pathological conditions. The present review aims to selectively evaluate the benefits of catechins and their polymeric structure on metabolic syndrome, a common disorder characterized by a cluster of three main risk factors: obesity, hypertension, and hyperglycemia. Patients with metabolic syndrome suffer chronic low inflammation state and oxidative stress both conditions effectively countered by flavanols and their polymers. The mechanism behind the activity of these molecules has been highlighted and correlated with the characteristic features present on their basic flavonoidic skelethon, as well as the efficient doses needed to perform their activity in both in vitro and in vivo studies. The amount of evidence provided in this review offers a starting point for flavanol dietary supplementation as a potential strategy to counteract several metabolic targets associated with metabolic syndrome and suggests a key role of albumin as flavanol-delivery system to the different target of action inside the organism.
C1 [Patane, Giuseppe Tancredi; Putaggio, Stefano; Tellone, Ester; Barreca, Davide; Ficarra, Silvana; Maffei, Carlo; Calderaro, Antonella; Lagana, Giuseppina] Univ Messina, Dept Chem Biol Pharmaceut & Environm Sci, Viale Ferdinando Stagno Alcontres 31, I-98166 Messina, Italy.
C3 University of Messina
RP Tellone, E; Barreca, D (corresponding author), Univ Messina, Dept Chem Biol Pharmaceut & Environm Sci, Viale Ferdinando Stagno Alcontres 31, I-98166 Messina, Italy.
EM giuseppe.patane@studenti.unime.it; stefano.putaggio@studenti.unime.it;
   ester.tellone@unime.it; davide.barreca@unime.it;
   silvana.ficarra@unime.it; carlo.maffei@studenti.unime.it;
   anto.calderaro@gmail.com; giuseppina.lagana@unime.it
RI Barreca, Davide/X-6802-2018
OI Patane, Giuseppe Tancredi/0009-0005-0792-5895; Ester,
   Tellone/0000-0003-2379-3392; BARRECA, Davide/0000-0002-1463-4069;
   LAGANA', Giuseppina/0000-0001-7521-1986
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NR 149
TC 23
Z9 24
U1 0
U2 18
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD MAY 25
PY 2023
VL 24
IS 11
AR 9228
DI 10.3390/ijms24119228
PG 20
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA I9FT6
UT WOS:001005772800001
PM 37298181
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Costamagna, MS
   Zampini, IC
   Alberto, MR
   Cuello, S
   Torres, S
   Pérez, J
   Quispe, C
   Schmeda-Hirschmann, G
   Isla, MI
AF Costamagna, M. S.
   Zampini, I. C.
   Alberto, M. R.
   Cuello, S.
   Torres, S.
   Perez, J.
   Quispe, C.
   Schmeda-Hirschmann, G.
   Isla, M. I.
TI Polyphenols rich fraction from Geoffroea decorticans fruits flour
   affects key enzymes involved in metabolic syndrome, oxidative stress and
   inflammatory process
SO FOOD CHEMISTRY
LA English
DT Article
DE Geoffroea decorticans; Chanar flour; Polyphenolic compounds; Metabolic
   syndrome; Antioxidant activity; Anti-inflammatory activity; Genotoxicity
ID ANTIOXIDANT PROPERTIES; CHOROTE INDIANS; LIQUID; CAPACITY; EXTRACTS;
   ARROPE; GREEN; WHITE; CHACO
AB Geoffroea decorticans (chanar), is widely distributed throughout Northwestern Argentina. Its fruit is consumed as flour, arrope or hydroalcoholic beverage. The chanar fruits flour was obtained and 39 phenolic compounds were tentatively identified by HPLC-MS/MSn. The compounds comprised caffeic acid glycosides, simple phenolics (protocatechuic acid and vanillic acid), a glycoside of vanillic acid, p-coumaric acid and its phenethyl ester as well as free and glycosylated flavonoids. The polyphenols enriched extract with and without gastroduodenal digestion inhibited enzymes associated with metabolic syndrome, including alpha-amylase, alpha-glucosidase, lipase and hydroxyl methyl glutaryl CoA reductase. The polyphenolic extract exhibited antioxidant activity by different mechanisms and inhibited the pro-inflammatory enzymes (ciclooxygenase, lipoxygenase and phospholipase A(2)). The polyphenolic extract did not showed mutagenic effect by Ames test against Salmonella typhimurium TA98 and TA100 strains.
   These findings add evidence that chanar fruit flour may be considered a functional food with preventive properties against diseases associated with oxidative stress, inflammatory mediators and metabolic syndrome. (C) 2015 Elsevier Ltd. All rights reserved.
C1 [Costamagna, M. S.; Zampini, I. C.; Alberto, M. R.; Cuello, S.; Torres, S.; Perez, J.; Isla, M. I.] Univ Nacl Tucuman, Inst Quim NOA INQUINOA CONICET, Fac Ciencias Nat, Lab Invest Prod Nat LIPRON, RA-4000 San Miguel De Tucuman, Tucuman, Argentina.
   [Costamagna, M. S.; Zampini, I. C.; Alberto, M. R.; Cuello, S.; Torres, S.; Perez, J.; Isla, M. I.] Univ Nacl Tucuman, IML, San Miguel De Tucuman, Tucuman, Argentina.
   [Quispe, C.; Schmeda-Hirschmann, G.] Univ Talca, Inst Quim Recursos Nat, Lab Quim Prod Nat, Talca, Chile.
C3 Universidad Nacional de Tucuman; Universidad Nacional de Tucuman;
   Universidad de Talca
RP Isla, MI (corresponding author), Univ Nacl Tucuman, CONICET, INQUINOA, San Lorenzo 1469, RA-4000 San Miguel De Tucuman, Tucuman, Argentina.
EM misla@tucbbs.com.ar
RI Torres, Sebastian/AAE-4510-2020; Alberto, Maria Rosa/AAS-3062-2021;
   Schmeda Hirschmann, Guillermo/G-1046-2010
OI Schmeda Hirschmann, Guillermo/0000-0002-9228-5378; Quispe,
   Cristina/0000-0002-2090-3288; TORRES, Sebastian/0000-0002-3593-831X;
   Alberto, Maria Rosa/0000-0002-4173-9499
FU FONDECYT [1120096]; PCCI [12067]; MINCyT [CH/11/13]; ANPCyT [PICT 1959];
   CONICET; SCAIT-UNT
FX We thank FONDECYT Project 1120096, PCCI 12067 and MINCyT (CH/11/13)
   "Valorizacion de frutos nativos sudamericanos", ANPCyT (PICT 1959);
   "Evaluacion de las propiedades nutricionales y funcionales de frutos
   nativos del noroeste argentino para su revalorizacion y aprovechamiento
   en el diseno de alimentos funcionales", CONICET and SCAIT-UNT for
   financial support.
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NR 39
TC 103
Z9 103
U1 0
U2 143
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0308-8146
EI 1873-7072
J9 FOOD CHEM
JI Food Chem.
PD JAN 1
PY 2016
VL 190
BP 392
EP 402
DI 10.1016/j.foodchem.2015.05.068
PG 11
WC Chemistry, Applied; Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Food Science & Technology; Nutrition & Dietetics
GA CS2SU
UT WOS:000361922800056
PM 26212988
DA 2025-06-11
ER

PT J
AU Roncal, CA
   Reungjui, S
   Sánchez-Lozada, LG
   Mu, W
   Sautin, YY
   Nakagawa, T
   Johnson, RJ
AF Roncal, Carlos A.
   Reungjui, Sirirat
   Gabriela Sanchez-Lozada, Laura
   Mu, Wei
   Sautin, Yuri Y.
   Nakagawa, Takahiko
   Johnson, Richard J.
TI Combination of Captopril and Allopurinol Retards Fructose-Induced
   Metabolic Syndrome
SO AMERICAN JOURNAL OF NEPHROLOGY
LA English
DT Article
DE Uric acid; High fructose diet; Insulin resistance; Hypertension
ID RENIN-ANGIOTENSIN SYSTEM; CONVERTING ENZYME-INHIBITOR; SERUM URIC-ACID;
   INSULIN SENSITIVITY; BLOOD-PRESSURE; CELL-PROLIFERATION; OXIDATIVE
   STRESS; ADIPOSE-TISSUE; NADPH OXIDASE; HYPERURICEMIA
AB Background: Both ACE inhibitors and allopurinol have been shown to partially prevent metabolic syndrome induced by fructose. We tested the hypothesis that combined therapy might be more effective at blocking the metabolic syndrome induced with fructose. Methods: Male Sprague-Dawley rats were fed a high fructose diet with or without allopurinol, captopril, or the combination for 20 weeks. A control group received a normal diet. All groups were pair-fed to assure equivalent caloric intake. Results: Despite reduced energy intake, the fructose-fed rats developed features of metabolic syndrome including elevated blood pressure, abdominal obesity, hypertriglyceridemia, hyperuricemia and hyperinsulinemia. While both allopurinol and captopril alone tended to reduce features of the metabolic syndrome, the combined therapy was synergistic, with significant reduction in blood pressure, less accumulation of abdominal fat, an improvement in the dyslipidemia and a complete prevention of insulin resistance. Conclusion: A high fructose diet can induce metabolic syndrome even in the setting of caloric restriction. Captopril and allopurinol synergistically reduce features of the metabolic syndrome, especially hypertension, insulin resistance and dyslipidemia. Combination allopurinol and ACE inhibitor therapy might provide a superior means to prevent diabetes and cardiovascular disease. Copyright (C) 2009 S. Karger AG, Basel
C1 [Roncal, Carlos A.; Gabriela Sanchez-Lozada, Laura; Nakagawa, Takahiko; Johnson, Richard J.] Univ Colorado, Div Renal Dis & Hypertens, Denver, CO 80202 USA.
   [Roncal, Carlos A.; Reungjui, Sirirat; Gabriela Sanchez-Lozada, Laura; Mu, Wei; Sautin, Yuri Y.; Nakagawa, Takahiko; Johnson, Richard J.] Univ Florida, Div Nephrol Hypertens & Renal Transplantat, Gainesville, FL USA.
   [Gabriela Sanchez-Lozada, Laura] INC Ignacio Chavez, Dept Nephrol, Mexico City, DF, Mexico.
   [Reungjui, Sirirat] Khon Kaen Univ, Div Nephrol, Khon Kaen, Thailand.
C3 University of Colorado System; University of Colorado Denver; State
   University System of Florida; University of Florida; Khon Kaen
   University
RP Johnson, RJ (corresponding author), Univ Colorado, Div Renal Dis & Hypertens, Box C281,12700 E 19th Ave,Res 2,Room 7015, Aurora, CO 80045 USA.
EM richard.johnson@ucdenver.edu
RI Anutrakulchai, Sirirat/L-3759-2013; Sanchez-Lozada, Laura/AAS-2104-2021
OI Sanchez-Lozada, Laura-Gabriela/0000-0003-0348-9617
FU US Public Health [DK-52121, HL-68607]; Anandamahidol Foundation of
   Thailand; CONACYT, Mexico [081054]
FX Support for the study was provided by US Public Health grants DK-52121
   and HL-68607. S. R. is supported by a fellowship from the Anandamahidol
   Foundation of Thailand. L. G. S.- L. is supported by Grant 081054 from
   CONACYT, Mexico.
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NR 46
TC 35
Z9 40
U1 0
U2 8
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0250-8095
EI 1421-9670
J9 AM J NEPHROL
JI Am. J. Nephrol.
PY 2009
VL 30
IS 5
BP 399
EP 404
DI 10.1159/000235731
PG 6
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 501EC
UT WOS:000270361300001
PM 19696478
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Danciu, AM
   Ghitea, TC
   Bungau, AF
   Vesa, CM
AF Danciu, Adrian Marius
   Ghitea, Timea Claudia
   Bungau, Alexa Florina
   Vesa, Cosmin Mihai
TI The Relationship Between Oxidative Stress, Selenium, and Cumulative Risk
   in Metabolic Syndrome
SO IN VIVO
LA English
DT Article
DE Oxidative stress; metabolic syndrome; FORD test; FORT test; selenium
ID ACNE; INFLAMMATION; CYTOKINE; MARKERS; HYPERGLYCEMIA; ANTIOXIDANTS;
   ASSOCIATION; ADIPONECTIN; MECHANISMS; BIOMARKERS
AB Background/Aim: Oxidative stress in association with metabolic syndrome represents a complex disease entity that has emerged as a significant public health challenge, and it is closely linked to an elevated risk of cardiovascular disease, type 2 diabetes, and even cancer. The objective of this study was to investigate the effectiveness of selenium supplementation in managing oxidative stress while considering a well-balanced diet based on a healthy lifestyle and diet therapy. Patients and Methods: The study included a total of 206 participants divided into three groups: the control group consisting of 35 individuals (17.0%) named LC, the diet therapy group comprising 119 individuals (57.8%) named LD, and the diet therapy group supplemented with selenium consisting of 52 individuals (25.2%) named LD+Se. Various clinical parameters such as body mass index (BMI), weight status, fat mass, visceral fat, and sarcopenia index, as well as paraclinical parameters including the HOMA index, cholesterol, triglycerides, C-reactive protein, and HGZ, were evaluated. Additionally, oxidative stress parameters using the FORD, FORT and MIXT tests were measured. Results: Selenium supplementation, along with FORD and FORT tests, demonstrated effectiveness in individuals with chronic venous
C1 [Danciu, Adrian Marius; Bungau, Alexa Florina] Univ Oradea, Doctoral Sch Biol & Biomed Sci, Oradea, Romania.
   [Ghitea, Timea Claudia] Univ Oradea, Fac Med & Pharm, Pharm Dept, Piata 1 Decembrie 10, Oradea 410068, Romania.
   [Vesa, Cosmin Mihai] Univ Oradea, Fac Med & Pharm, Med Dept, Oradea, Romania.
C3 University of Oradea; University of Oradea; University of Oradea
RP Bungau, AF (corresponding author), Univ Oradea, Doctoral Sch Biol & Biomed Sci, Oradea, Romania.; Ghitea, TC (corresponding author), Univ Oradea, Fac Med & Pharm, Pharm Dept, Piata 1 Decembrie 10, Oradea 410068, Romania.
EM timea.ghitea@csud.uoradea.ro; pradaalexaflorina@gmail.com
RI Mihai, Vesa/AAE-5495-2019; Bungau, Alexa/AGY-4752-2022; Ghitea, Timea
   Claudia/AAJ-4273-2021
OI Cosmin Mihai, Vesa/0000-0001-5071-9601; Ghitea, Timea
   Claudia/0000-0001-8981-1958
FU University of Oradea
FX The Authors would like to thank the University of Oradea, for supporting
   the payment of the publication fee, through an internal project.
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NR 53
TC 8
Z9 8
U1 2
U2 3
PU INT INST ANTICANCER RESEARCH
PI ATHENS
PA EDITORIAL OFFICE 1ST KM KAPANDRITIOU-KALAMOU RD KAPANDRITI, PO BOX 22,
   ATHENS 19014, GREECE
SN 0258-851X
EI 1791-7549
J9 IN VIVO
JI In Vivo
PD NOV-DEC
PY 2023
VL 37
IS 6
BP 2877
EP 2887
DI 10.21873/invivo.13406
PG 11
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA Z5RC7
UT WOS:001112634900046
PM 37905638
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Martland, R
   Onwumere, J
   Stubbs, B
   Gaughran, F
AF Martland, Rebecca
   Onwumere, Juliana
   Stubbs, Brendon
   Gaughran, Fiona
TI Study protocol for a pilot high-intensity interval training intervention
   in inpatient mental health settings: a two-part study using a randomised
   controlled trial and naturalistic study design
SO PILOT AND FEASIBILITY STUDIES
LA English
DT Article
DE Severe mental illness; Physical health; Exercise; Intervention;
   Inpatient
ID MAJOR DEPRESSIVE DISORDER; PHYSICAL-ACTIVITY; CIGARETTE CRAVINGS; GAIT
   DISTURBANCES; AEROBIC EXERCISE; RATING-SCALE; SCHIZOPHRENIA; ILLNESS;
   INDIVIDUALS; ADULTS
AB Background: Severe mental illnesses (SMI), including schizophrenia spectrum disorder, bipolar disorder and major depressive disorder, are associated with physical health comorbidities and premature mortality. Physical activity and structured exercise have a beneficial impact on cardiometabolic risk and ameliorate mental health symptomology and cognition. This protocol describes a feasibility study for a high-intensity interval training (HIIT) intervention among inpatients with SMI, to improve their physical and mental health.
   Methods: The feasibility study follows a two-part design owing to COVID-19-related adaptations to project design: (a) a non-blinded randomised controlled trial (RCT) of 12 weeks of bicycle-based HIIT, delivered twice weekly in a face-to-face, one-to-one setting, compared to treatment as usual (TAU) and (b) a naturalistic study of inpatient HIIT; eligible participants will be invited to two sessions of HIIT per week, delivered by the research team remotely or in person. Additionally, participants in the naturalistic study may use the bike to conduct self-directed sessions of their chosen length and intensity. We will measure the feasibility and acceptability of the HIIT intervention as primary outcomes, alongside secondary and tertiary outcomes evaluating the physical, mental and cognitive effects of HIIT. The study aims to recruit 40 patients to the RCT and 6-8 patients to the naturalistic design.
   Discussion: Exercise is a modifiable lifestyle barrier that can reverse cardiometabolic disease risk. If HIIT is found to be feasible and acceptable in inpatients with SMI, there would be scope for large-scale work to evaluate the clinical, cost and implementation effectiveness of HIIT in inpatient mental health settings.
C1 [Martland, Rebecca; Gaughran, Fiona] Kings Coll London, Dept Psychosis Studies, Inst Psychiat Psychol & Neurosci IoPPN, London, England.
   [Onwumere, Juliana; Stubbs, Brendon; Gaughran, Fiona] South London & Maudsley NHS Fdn Trust, London, England.
   [Onwumere, Juliana] Kings Coll London, Inst Psychiat Psychol & Neurosci IoPPN, Dept Psychol, London, England.
   [Stubbs, Brendon] Kings Coll London, Inst Psychiat Psychol & Neurosci IoPPN, Dept Psychol Med, London, England.
C3 University of London; King's College London; South London & Maudsley NHS
   Trust; University of London; King's College London; University of
   London; King's College London
RP Martland, R (corresponding author), Kings Coll London, Dept Psychosis Studies, Inst Psychiat Psychol & Neurosci IoPPN, London, England.
EM rebecca.martland@kcl.ac.uk
RI Gaughran, Fiona/AAC-7160-2019; Stubbs, Brendon/X-1904-2018; Stubbs,
   Brendon/C-5696-2015; Gaughran, Fiona/H-5495-2011
OI Stubbs, Brendon/0000-0001-7387-3791; Martland, Rebecca
   Nicole/0000-0002-4080-0171; Gaughran, Fiona/0000-0001-7414-5569
FU National Institute for Health Research (NIHR) Biomedical Research Centre
   at South London and Maudsley NHS Foundation Trust; King's College
   London; Health Education England (HEE) [ICA-CL-2017-03-001]; National
   Institute for Health Research (NIHR) [ICA-CL-2017-03-001]; Maudsley
   Charity; National Institute for Health Research (NIHR) Applied Research
   Collaboration South London (NIHR ARC South London) at King's College
   Hospital NHS Foundation Trust
FX at South Lon This paper represents independent research funded by the
   National Institute for Health Research (NIHR) Biomedical Research Centre
   at South London and Maudsley NHS Foundation Trust and King's College
   London. RM is supported by a PhD studentship from the NIHR Biomedical
   Research Centre at South London and Maudsley NHS Foundation Trust and
   King's College London. BS is supported by a Clinical Lectureship
   (ICA-CL-2017-03-001) jointly funded by Health Education England (HEE)
   and the National Institute for Health Research (NIHR). FG and JO are
   part supported by the National Institute for Health Research's (NIHR)
   Biomedical Research Centre at South London and Maudsley NHS Foundation
   Trust and King's College London. FG is also supported by the Maudsley
   Charity and the National Institute for Health Research (NIHR) Applied
   Research Collaboration South London (NIHR ARC South London) at King's
   College Hospital NHS Foundation Trust. The views expressed are those of
   the authors and not necessarily those of the NIHR or the Department of
   Health and Social Care. The funding partners had no involvement in the
   study at any stage, nor did they influence the decision to publish.
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NR 83
TC 2
Z9 2
U1 0
U2 10
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 2055-5784
J9 PILOT FEASIBILITY ST
JI Pilot Feasibility Stud.
PD NOV 8
PY 2021
VL 7
IS 1
AR 198
DI 10.1186/s40814-021-00937-6
PG 14
WC Medicine, Research & Experimental
WE Emerging Sources Citation Index (ESCI)
SC Research & Experimental Medicine
GA WT3UI
UT WOS:000715792800003
PM 34749822
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Naraki, K
   Rahbardar, MG
   Ajiboye, BO
   Hosseinzadeh, H
AF Naraki, Karim
   Rahbardar, Mahboobeh Ghasemzadeh
   Ajiboye, Basiru Olaitan
   Hosseinzadeh, Hossein
TI The effect of ellagic acid on the metabolic syndrome: A review article
SO HELIYON
LA English
DT Review
DE Hyperlipidemias; Hypoglycemic agents; Hyperglycemia; Oxidative stress;
   Glucose; Insulins; Lipoproteins; Interleukins
ID OXIDATIVE STRESS; DIABETES-MELLITUS; HIGH GLUCOSE; CARDIAC-ARRHYTHMIAS;
   MEDICINAL-PLANTS; ALPHA-MANGOSTIN; HYPERTENSION; MANAGEMENT; OBESITY;
   ACTIVATION
AB Objective: (s): Metabolic syndrome is a collection of metabolic abnormalities that includes hyperglycemia, dyslipidemia, hypertension, and obesity. Ellagic acid is found in various fruits and vegetables. It has been reported to have several pharmacological properties, such as antibacterial, antifungal, antiviral, anti-inflammatory, hepatoprotective, cardioprotective, chemopreventive, neuroprotective, gastroprotective, and antidiabetic. Our current study aims to shed light on the probable efficiency of ellagic acid in managing metabolic syndrome and its complications.Materials and methods: To prepare the present review, the databases or search engines utilized included Scopus, PubMed, Science Direct, and Google Scholar, and relevant articles have been gathered with no time limit until March 2023.Results: Several investigations indicated that ellagic acid could be a potent compound for the treatment of many disorders such as diabetes, hypertension, and hyperlipidemia by various mechanisms, including increasing insulin secretion, insulin receptor substrate protein 1 expression, regulating glucose transporter 4, triglyceride, total cholesterol, low-density lipoprotein (LDL), high-density lipoprotein (HDL), attenuating tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), reactive oxygen species (ROS), malondialdehyde (MDA), and oxidative stress in related tissues. Furthermore, ellagic acid ameliorates mitochondrial function, upregulates uncoupling protein 1 (found in brown and white adipose tissues), and regulates blood levels of nitrate/nitrite and vascular relaxations in response to acetylcholine and sodium nitroprusside.Conclusion: Ellagic acid can treat or manage metabolic syndrome and associated complications, according to earlier studies. To validate the beneficial effects of ellagic acid on metabolic syndrome, additional preclinical and clinical research is necessary.
C1 [Naraki, Karim] Mashhad Univ Med Sci, Student Res Comm, Mashhad, Iran.
   [Naraki, Karim; Hosseinzadeh, Hossein] Mashhad Univ Med Sci, Sch Pharm, Dept Pharmacodynam & Toxicol, Mashhad, Iran.
   [Ajiboye, Basiru Olaitan] Fed Univ Oye Ekiti, Dept Biochem, Phytomed & Mol Toxicol Res Lab, Oye Ekiti, Ekiti State, Nigeria.
   [Rahbardar, Mahboobeh Ghasemzadeh; Hosseinzadeh, Hossein] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Pharmaceut Res Ctr, Mashhad, Iran.
C3 Mashhad University of Medical Sciences; Mashhad University of Medical
   Sciences; Mashhad University of Medical Sciences
RP Hosseinzadeh, H (corresponding author), Mashhad Univ Med Sci, Pharmaceut Technol Inst, Pharmaceut Res Ctr, Mashhad, Iran.
EM hosseinzadehh@mums.ac.ir
RI Ajiboye, Basiru/AIF-3989-2022; Ghasemzadeh Rahbardar,
   Mahboobeh/V-4452-2019; Hosseinzadeh, Hossein/F-3013-2010
OI naraki, karim/0000-0001-7767-2516; Hosseinzadeh,
   Hossein/0000-0002-3483-851X; Ghasemzadeh Rahbardar,
   Mahboobeh/0000-0002-5491-572X
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NR 108
TC 24
Z9 26
U1 11
U2 29
PU CELL PRESS
PI CAMBRIDGE
PA 50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA
EI 2405-8440
J9 HELIYON
JI Heliyon
PD NOV
PY 2023
VL 9
IS 11
AR e21844
DI 10.1016/j.heliyon.2023.e21844
EA NOV 2023
PG 13
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA Z2MK3
UT WOS:001110467900001
PM 38027887
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Abraham, NG
   Junge, JM
   Drummond, GS
AF Abraham, Nader G.
   Junge, Joshua M.
   Drummond, George S.
TI Translational Significance of Heme Oxygenase in Obesity and Metabolic
   Syndrome
SO TRENDS IN PHARMACOLOGICAL SCIENCES
LA English
DT Review
ID GENE PROMOTER POLYMORPHISM; HIGH-FAT DIET; IMPROVES INSULIN SENSITIVITY;
   CORONARY-ARTERY-DISEASE; NF-KAPPA-B; EXTRACELLULAR-SUPEROXIDE DISMUTASE;
   HEMOGLOBIN SCAVENGER RECEPTOR; INCREASES ADIPONECTIN LEVELS; HUMAN
   BILIVERDIN REDUCTASE; CELL-DERIVED ADIPOCYTES
AB The global epidemic of obesity continues unabated with sequelae of diabetes and metabolic syndrome. This review reflects the dramatic increase in research on the role of increased expression of heme oxygenase (HO)-1/HO-2, biliverdin reductase, and HO activity on vascular disease. The HO system engages with other systems to mitigate the deleterious effects of oxidative stress in obesity and cardiovascular disease (CVD). Recent reports indicate that HO-1/HO-2 protein expression and HO activity have several important roles in hemostasis and reactive oxygen species (ROS)-dependent perturbations associated with metabolic syndrome. HO-1 protects tissue during inflammatory stress in obesity through the degradation of pro-oxidant heme and the production of carbon monoxide (CO) and bilirubin, both of which have anti-inflammatory and antiapoptotic properties. By contrast, repression of HO-1 is associated with increases of cellular heme and inflammatory conditions including hypertension, stroke, and atherosclerosis. HO-1 is a major focus in the development of potential therapeutic strategies to reverse the clinical complications of obesity and metabolic syndrome.
C1 [Abraham, Nader G.; Junge, Joshua M.; Drummond, George S.] New York Med Coll, Dept Med, Sch Med, Valhalla, NY 10595 USA.
   [Abraham, Nader G.; Junge, Joshua M.; Drummond, George S.] New York Med Coll, Dept Pharm, Sch Med, Valhalla, NY 10595 USA.
   [Abraham, Nader G.] Marshall Univ, Joan C Edwards Sch Med, Huntington, WV 25701 USA.
C3 New York Medical College; New York Medical College; Marshall University
RP Abraham, NG (corresponding author), New York Med Coll, Dept Med, Sch Med, Valhalla, NY 10595 USA.
EM nader_abraham@nymc.edu
OI Junge, Joshua/0000-0001-8613-9529
FU National Institutes of Health (NIH) grants [HL55601, HL34300]
FX This work was supported by National Institutes of Health (NIH) grants
   HL55601 and HL34300 (N.G.A.). We thank Mrs Jennifer Brown for her
   outstanding assistance in preparing the manuscript.
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NR 250
TC 112
Z9 114
U1 0
U2 28
PU ELSEVIER SCIENCE LONDON
PI LONDON
PA 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND
SN 0165-6147
EI 1873-3735
J9 TRENDS PHARMACOL SCI
JI Trends Pharmacol. Sci.
PD JAN
PY 2016
VL 37
IS 1
BP 17
EP 36
DI 10.1016/j.tips.2015.09.003
PG 20
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA DB0NA
UT WOS:000368203600003
PM 26515032
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Krueger, JG
   Brunner, PM
AF Krueger, James G.
   Brunner, Patrick M.
TI Interleukin-17 alters the biology of many cell types involved in the
   genesis of psoriasis, systemic inflammation and associated comorbidities
SO EXPERIMENTAL DERMATOLOGY
LA English
DT Review
DE cardiovascular disease; keratinocyte; metabolic syndrome; obesity;
   review
ID COLLAGEN-INDUCED ARTHRITIS; METABOLIC SYNDROME; TH17 CELLS; VASCULAR
   INFLAMMATION; RHEUMATOID-ARTHRITIS; MONOCLONAL-ANTIBODY; CARDIOVASCULAR
   RISK; IL-17 RECEPTOR; ADIPOSE-TISSUE; MOUSE MODEL
AB Psoriasis is a chronic, immune-mediated, systemic inflammatory disease that is defined by a characteristic skin reaction produced when elevated levels of inflammatory cytokines such as interleukin (IL)-17 alter the growth and differentiation of skin cells. The pathogenesis of comorbid conditions associated with psoriasis, including psoriatic arthritis, cardiovascular disease, obesity, metabolic syndrome, liver disorders, renal disease and depression, is also largely affected by inflammation. In this review, we examine the effect of IL-17 on the inflammatory pathways in a variety of different cell types, including keratinocytes, as well as epithelial cells of the colon, kidney, gut and liver. Additionally, we investigate the role of IL-17 in mediating the psoriasis-associated comorbidities detailed above.
C1 [Krueger, James G.; Brunner, Patrick M.] Rockefeller Univ, Lab Invest Dermatol, 1230 York Ave, New York, NY 10021 USA.
C3 Rockefeller University
RP Krueger, JG (corresponding author), Rockefeller Univ, Lab Invest Dermatol, 1230 York Ave, New York, NY 10021 USA.
EM kruegej@mail.rockefeller.edu
OI Brunner, Patrick M./0000-0002-3488-3345
FU Novartis Pharmaceuticals Corporation
FX Both authors contributed to analysis and interpretation of the data
   presented, wrote the manuscript and approved the final version.
   Technical assistance with editing and styling of the manuscript for
   submission was provided by Oxford PharmaGenesis Inc., funded by Novartis
   Pharmaceuticals Corporation. Authors were fully responsible for all
   content and editorial decisions and received no financial support or
   other form of compensation related to the manuscript.
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NR 121
TC 93
Z9 96
U1 1
U2 21
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0906-6705
EI 1600-0625
J9 EXP DERMATOL
JI Exp. Dermatol.
PD FEB
PY 2018
VL 27
IS 2
BP 115
EP 123
DI 10.1111/exd.13467
PG 9
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA FU2KT
UT WOS:000423679700001
PM 29152791
OA hybrid
DA 2025-06-11
ER

PT J
AU Tsodikov, F
   Schechter, M
   Goldsmith, R
   Peleg, L
   Baloush-Kleinman, V
   Rozenberg, A
   Yanuv, I
   Gimelfarb, Y
   Mosenzon, O
   Endevelt, R
AF Tsodikov, Faina
   Schechter, Meir
   Goldsmith, Rebecca
   Peleg, Lilach
   Baloush-Kleinman, Vered
   Rozenberg, Aliza
   Yanuv, Ilan
   Gimelfarb, Yuri
   Mosenzon, Ofri
   Endevelt, Ronit
TI The effect of lifestyle intervention on cardiometabolic risk factors in
   mental health rehabilitation hostel residents at-risk: a
   cluster-randomized controlled 15-month trial
SO INTERNATIONAL JOURNAL OF OBESITY
LA English
DT Article
ID PREMATURE MORTALITY; EXCESS MORTALITY; ILLNESS; METAANALYSIS;
   SCHIZOPHRENIA; 1ST-EPISODE; MANAGEMENT; OUTCOMES; ISRAEL; ADULTS
AB Objective Cardiometabolic disorders contribute to morbidity and mortality in people with severe mental illnesses (SMI), yet lifestyle-intervention efficacy in patients with SMI is unclear. Israel's unique mental-health rehabilitation hostels (MHRHs) provide housing to subjects with SMI. We tested how multi-component lifestyle intervention affects cardiometabolic risk-factors in at-risk SMI populations residing in MHRHs. Methods In a prospective, cluster-randomized, controlled study, six MHRHs, paired by residents' functioning level, were randomized to lifestyle intervention (nutrition education, physical education), or usual care. Subjects recruited included those with >= 1 of: BMI > 25 kg/m(2); plasma triglycerides >= 150 mg/dL; HbA1c >= 5.7%; fasting plasma glucose >= 100 mg/dL and plasma HDL < 40((men))/ 50((women)) mg/dL. Primary outcome was BMI change after 15 months; other outcomes were plasma lipids levels and glycemic control. Low cooperation in one MHRH pair led to their exclusion, the others were assigned to intervention or control. Results Eighty residents were enrolled to intervention groups and 74 to control. Compared to baseline, intervention-arm participants experienced improvements in BMI (-0.83 kg/m(2) [-1.36, -0.29] (95%CI)), triglycerides (-30.60 mg/dL [-49.39, -11.82](95%CI)) and LDL (-15.51 mg/dL [-24.53, -6.50](95%CI)) (all P <= 0.003). BMI improvement correlated with number of dietitian consultations (r = -0.30; P = 0.001). No significant differences were found between treatment arms in BMI (-0.46 kg/m(2) [-1.11, 0.18](95%CI);P = 0.189), triglycerides (-24.70 mg/dL [-57.66, 8.25](95%CI)), LDL (-9.24 mg/dL [-20.50, 2.03](95%CI)), HDL and glycemic control. Conclusions Lifestyle intervention significantly improved BMI, LDL and triglycerides compared to baseline in at-risk MHRHs residents with SMI, yet compared to usual care the differences did not reach statistical significance. The association between the number of dietitian's consultations and BMI improvement suggests that programs should highlight participants' adherence.
C1 [Tsodikov, Faina; Goldsmith, Rebecca; Peleg, Lilach; Endevelt, Ronit] Minist Hlth, Nutr Div, Jerusalem, Israel.
   [Schechter, Meir; Rozenberg, Aliza; Yanuv, Ilan; Mosenzon, Ofri] Hadassah Med Ctr, Dept Endocrinol & Metab, Diabet Unit, Jerusalem, Israel.
   [Schechter, Meir; Rozenberg, Aliza; Yanuv, Ilan] Hebrew Univ Jerusalem, Fac Med, Jerusalem, Israel.
   [Baloush-Kleinman, Vered] Minist Hlth, Div Med, Mental Hlth Rehabil Syst, Jerusalem, Israel.
   [Gimelfarb, Yuri] Abarbanel Mental Hlth Ctr, Bat Yam, Israel.
   [Gimelfarb, Yuri] Tel Aviv Univ, Sackler Fac Med, Tel Aviv, Israel.
   [Endevelt, Ronit] Univ Haifa, Sch Publ Hlth, Haifa, Israel.
C3 Ministry of Health - Israel; Hebrew University of Jerusalem; Hadassah
   University Medical Center; Hadassah University Hospital; Hebrew
   University of Jerusalem; Ministry of Health - Israel; Tel Aviv
   University; Tel Aviv University; Sackler Faculty of Medicine; University
   of Haifa
RP Tsodikov, F (corresponding author), Minist Hlth, Nutr Div, Jerusalem, Israel.
EM faina.tsodikov@gmail.com
RI Schechter, Meir/IUN-6078-2023
OI Endevelt, Ronit/0000-0002-0866-523X; Gimelfarb,
   Yuri/0000-0002-5059-7648; Schechter, Meir/0000-0002-5071-3143
FU Israeli Otzma Authority [12181]
FX This study was funded by the Israeli Otzma Authority in 2015, grant
   number 3-12181. This paper was presented in part at the annual
   conference of Otzma Authority for the presentation of studies in
   diabetes (2018, October), Tel-HaShomer, Israel.
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   WHO, EXC MORT PERS SEV ME
NR 28
TC 2
Z9 2
U1 0
U2 5
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0307-0565
EI 1476-5497
J9 INT J OBESITY
JI Int. J. Obes.
PD MAY
PY 2022
VL 46
IS 5
BP 926
EP 934
DI 10.1038/s41366-022-01063-w
EA JAN 2022
PG 9
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 0V9BK
UT WOS:000741911100002
PM 35022545
DA 2025-06-11
ER

PT J
AU Stanley, S
   Laugharne, J
AF Stanley, Susanne
   Laugharne, Jonathan
TI The Impact of Lifestyle Factors on the Physical Health of People with a
   Mental Illness: a Brief Review
SO INTERNATIONAL JOURNAL OF BEHAVIORAL MEDICINE
LA English
DT Review
DE Mental illness; Metabolic syndrome; Lifestyle; Cardiovascular disease;
   Type 2 diabetes; Primary health care
ID CORONARY-HEART-DISEASE; MEDICAL-CARE; SCHIZOPHRENIA; RISK; PREDICTORS;
   BEHAVIORS; DISORDER; QUALITY; OBESITY; ACCESS
AB People with a mental illness are much more likely to experience poor physical health when compared to the general population, showing a higher propensity to develop the metabolic syndrome. Past focus has predominantly been upon individuals treated with antipsychotics, yet poor physical health is occurring across diagnoses.
   The purpose of this paper is to draw attention to the major factors within the domain of lifestyle in order to support the need for more detailed and rigorous physical health assessment and ongoing monitoring for people with a mental illness.
   This paper reviews existing evidence relating to lifestyle factors such as low exercise levels, poor diet and nutrition, high cholesterol levels, tobacco smoking and poor dental care, contributing to poor physical health such as a higher incidence of cardiovascular disease and type 2 diabetes. An integrative review was conducted from a multi-disciplinary search of online databases and journals, focusing upon mental illness and lifestyle issues predominant in the literature.
   The findings reviewed here suggest that greater attention should be paid to the physical health assessment and ongoing monitoring of all people with mental health disorders so that preventable illness does not result in higher levels of morbidity and mortality for this disadvantaged population.
   Early identification aids preventive interventions and assists clinicians and mental health staff to more effectively treat emergent physical health problems.
C1 [Stanley, Susanne; Laugharne, Jonathan] Univ Western Australia, Fremantle Hosp, Sch Psychiat & Clin Neurosci, Community Culture & Mental Hlth Unit, Fremantle, WA 6160, Australia.
C3 South Metropolitan Health Service; Fiona Stanley Fremantle Hospitals
   Group; Fremantle Hospital; University of Western Australia
RP Stanley, S (corresponding author), Univ Western Australia, Fremantle Hosp, Sch Psychiat & Clin Neurosci, Community Culture & Mental Hlth Unit, W Block,L6,1 Alma St, Fremantle, WA 6160, Australia.
EM Susanne.Stanley@uwa.edu.au
RI Stanley, Susanne/H-5882-2014
OI Stanley, Susanne/0000-0002-0404-9018
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NR 34
TC 36
Z9 40
U1 0
U2 42
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1070-5503
EI 1532-7558
J9 INT J BEHAV MED
JI Int. J. Behav. Med.
PD APR
PY 2014
VL 21
IS 2
BP 275
EP 281
DI 10.1007/s12529-013-9298-x
PG 7
WC Psychology, Clinical
WE Social Science Citation Index (SSCI)
SC Psychology
GA AE7JJ
UT WOS:000334173500008
PM 23443909
DA 2025-06-11
ER

PT J
AU Escouto, LD
   Batista, TJ
   Peixoto, P
   Firmino, FT
   Ronchi, SN
   Barroso, MED
   Kampke, EH
   de Andrade, TU
   de Melo, AF Jr
   Bissoli, NS
AF Escouto, Leonardo da Silva
   Batista, Thatiany Jardim
   Peixoto, Pollyana
   Firmino, Felipe Tonon
   Ronchi, Silas Nascimento
   Barroso, Maria Eduarda de Souza
   Kampke, Edgar Hell
   de Andrade, Tadeu Uggere
   de Melo Junior, Antonio Ferreira
   Bissoli, Nazare Souza
TI Probiotic Kefir Improves Renal Disorders in Ovariectomized Female SHR
   with High Fructose Intake-Induced Metabolic Syndrome
SO PROBIOTICS AND ANTIMICROBIAL PROTEINS
LA English
DT Article; Early Access
DE Kefir; Renal function; Metabolic syndrome; Female SHR; Oxidative stress
ID HORMONE REPLACEMENT THERAPY; NITRIC-OXIDE SYNTHASE; TUBULOGLOMERULAR
   FEEDBACK; INSULIN SENSITIVITY; OXIDATIVE STRESS; SEX-DIFFERENCES;
   DNA-DAMAGE; DIET; KIDNEY; HYPERTENSION
AB Women in postmenopausal period may present several comorbidities linked to metabolic syndrome (MetS). Our hypothesis is that kefir may prevent the deleterious effects in renal function in an experimental model of metabolic syndrome (MetS) and ovarian hormone deficiency. Young female spontaneously hypertensive rats (SHR) were divided into four groups: ovariectomized (OVX) control, OVX fructose, OVX kefir, and OVX kefir + fructose. They received kefir (5% w/v) via gavage for 8 weeks, while fructose (10% w/v) was available ad libitum. In ponderal parameters and glucose metabolism, we observe that fructose-overloaded groups (OF and OKF) showed increased weight, visceral fat, and fasting blood glucose. However, OKF partially reduced glycemic peak in the glucose tolerance test. Moreover, the standard method for the measurement of renal function showed that OF and OKF groups had a reduction in glomerular filtration rate, and surprisingly OKF exhibited increased renal flow (RBF and RPF) and decreased resistance (RVR). These might be associated with the findings in oxidative stress and nitric oxide (NO) bioavailability, in which kefir in the OKF group was capable of increasing total nitrogen oxides (NOx), attenuate the generation of hydrogen peroxide (DCF) and peroxynitrite (HPF), and also decreased the elevated microalbuminuria promoted by fructose even though the systemic blood pressure between the groups did not differ. Taking together our results, in the present study, kefir showed favorable effects in the model of metabolic syndrome and ovarian hormone deficiency (OKF), potentially protecting the kidney from the deleterious effects of fructose.
C1 [Escouto, Leonardo da Silva; Batista, Thatiany Jardim; Peixoto, Pollyana; Firmino, Felipe Tonon; Ronchi, Silas Nascimento; Kampke, Edgar Hell; Bissoli, Nazare Souza] Univ Fed Espirito Santo, Dept Physiol Sci, Vitoria, ES, Brazil.
   [de Andrade, Tadeu Uggere] Univ Vila Velha UVV, Dept Pharm, Vila Velha, Brazil.
   [de Melo Junior, Antonio Ferreira] Univ NOVA Lisboa, Fac Ciencias Med NMS FCM, NOVA Med Sch, iNOVA4HlTH, P-1159056 Lisbon, Portugal.
   [de Melo Junior, Antonio Ferreira] Ctr Clin & Acad Lisboa, P-1156056 Lisbon, Portugal.
C3 Universidade Federal do Espirito Santo; Centro Universitario Vila Velha;
   Universidade Nova de Lisboa
RP de Melo, AF Jr (corresponding author), Univ NOVA Lisboa, Fac Ciencias Med NMS FCM, NOVA Med Sch, iNOVA4HlTH, P-1159056 Lisbon, Portugal.; de Melo, AF Jr (corresponding author), Ctr Clin & Acad Lisboa, P-1156056 Lisbon, Portugal.
EM melo.junior@nms.unl.pt
RI Barroso, Maria/AAP-5507-2021; Peixoto, Pollyana/AAR-3079-2020; Andrade,
   Tadeu/M-4616-2016; Ferreira de Melo Junior, Antonio/LIG-3474-2024;
   Bissoli, Nazare/ABA-2679-2021
OI Ferreira de Melo Junior, Antonio/0000-0001-6831-1823
FU FCT|FCCN (b-on); Fundacao de Amparo a Pesquisa e Inovacao do Espirito
   Santo (Fapes) [23/2018 (591/2018), 15/2022 (687/2022)]; Fapes Foundation
   Scholarship; Conselho Nacional de Desenvolvimento Cientifico e
   Tecnologico (CNPq), Brazil
FX Open access funding provided by FCT|FCCN (b-on). This project was
   supported by the Fundacao de Amparo a Pesquisa e Inovacao do Espirito
   Santo (Fapes): Grants 23/2018 (591/2018) and 15/2022 (687/2022). L.S.E.
   was a recipient of Fapes Foundation Scholarship. Conselho Nacional de
   Desenvolvimento Cientifico e Tecnologico (CNPq), Brazil.
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NR 111
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1867-1306
EI 1867-1314
J9 PROBIOTICS ANTIMICRO
JI Probiotics Antimicrob. Proteins
PD 2025 MAR 13
PY 2025
DI 10.1007/s12602-025-10490-w
EA MAR 2025
PG 17
WC Biotechnology & Applied Microbiology; Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Microbiology
GA 0CE6L
UT WOS:001443890500001
PM 40080096
OA hybrid
DA 2025-06-11
ER

PT J
AU Vogelzangs, N
   Comijs, HC
   Voshaar, RCO
   Stek, ML
   Penninx, BWJH
AF Vogelzangs, Nicole
   Comijs, Hannie C.
   Voshaar, Richard C. Oude
   Stek, Max L.
   Penninx, Brenda W. J. H.
TI Late-life depression symptom profiles are differentially associated with
   immunometabolic functioning
SO BRAIN BEHAVIOR AND IMMUNITY
LA English
DT Article
DE Depression; Inflammation; Metabolic syndrome; Cohort study; Elderly
ID BODY-MASS INDEX; METABOLIC SYNDROME; TREATMENT RESPONSE; ANTIDEPRESSANT
   MEDICATION; INFLAMMATORY CYTOKINES; BLOOD-PRESSURE; METAANALYSIS;
   RELIABILITY; DISEASE; HEALTH
AB Growing evidence suggests immune and metabolic dysregulation among depressed persons, possibly restricted to specific subgroups. This study explores the association between depressive disorders and characteristics with immunometabolic functioning among older persons. Data are from the baseline assessment of the Netherlands Study of Depression in Older Persons, including 131 non-depressed and 358 depressed (6-month DSM-IV major depressive disorder) persons (60-93 years). Immune (C-reactive protein, interleukin [IL]-6) and metabolic (waist circumference, triglycerides, high-density lipoprotein cholesterol, blood pressure, fasting glucose) factors were measured. Depression characteristics included severity, age of onset, symptom profile (atypical/melancholic) and antidepressant use. Depressed persons showed lower IL-6 levels compared with non-depressed persons. Depressed persons, except those with atypical depression, had lower waist circumference, lower glucose levels and scored lower on an overall index including all immunometabolic factors. Low waist circumference was more pronounced among those with less severe depression and those with a later age of onset, whom also had lower blood pressure levels. Atypical depression was associated with higher triglyceride levels. Antidepressant use was not clearly associated with immunometabolic functioning. To conclude, contrary to our expectations, we found overall immunometabolic downregulation in older depressed persons, in particular among those with less severe symptoms and those with late-life onset. However, persons with atypical depression presented with metabolic upregulation compared with other depressed persons. Taking depression symptom profiles into account is important when examining biological dysregulation in late-life depression. (C) 2014 Elsevier Inc. All rights reserved.
C1 [Vogelzangs, Nicole; Comijs, Hannie C.; Stek, Max L.; Penninx, Brenda W. J. H.] Vrije Univ Amsterdam, Med Ctr, Dept Psychiat, Amsterdam, Netherlands.
   [Vogelzangs, Nicole; Comijs, Hannie C.; Stek, Max L.; Penninx, Brenda W. J. H.] Vrije Univ Amsterdam, Med Ctr, EMGO Inst Hlth & Care Res, Amsterdam, Netherlands.
   [Voshaar, Richard C. Oude] Univ Groningen, Univ Med Ctr Groningen, Dept Psychiat, NL-9713 AV Groningen, Netherlands.
C3 Vrije Universiteit Amsterdam; Vrije Universiteit Amsterdam; University
   of Groningen
RP Vogelzangs, N (corresponding author), AJ Ernststr 1187, NL-1081 HL Amsterdam, Netherlands.
EM n.vogelzangs@vumc.nl
RI Penninx, Brenda/S-7627-2017
OI Oude Voshaar, Richard/0000-0003-1501-4774
FU EMGO Institute for Health and Care Research; VICI grant (NWO)
   [91811602]; Fonds NutsOhra; Stichting tot Steun VCVGZ; NARSAD; Brain and
   Behaviour Research Fund
FX The infrastructure of the NESDO study (http://nesdo.amstad.nl) is funded
   through the Fonds NutsOhra, Stichting tot Steun VCVGZ, NARSAD, The Brain
   and Behaviour Research Fund, and the participating universities and
   mental health care organizations (VU University Medical Center, Leiden
   University Medical Center, University Medical Center Groningen,
   University Medical Center St Radboud, GGZinGeest, GGNet, GGZ Nijmegen,
   GGZ Rivierduinen, Lentis, and Parnassia). N.V. was supported through a
   fellowship from the EMGO Institute for Health and Care Research, and
   B.P. through a VICI grant (NWO grant 91811602). Funding sources had no
   role in study design; in the collection, analysis and interpretation of
   data; in the writing of the report; and in the decision to submit the
   article for publication. Authors have no disclosures to report.
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NR 48
TC 26
Z9 27
U1 0
U2 8
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0889-1591
EI 1090-2139
J9 BRAIN BEHAV IMMUN
JI Brain Behav. Immun.
PD OCT
PY 2014
VL 41
BP 109
EP 115
DI 10.1016/j.bbi.2014.05.004
PG 7
WC Immunology; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Immunology; Neurosciences & Neurology; Psychiatry
GA AP2MD
UT WOS:000341905400013
PM 24838021
DA 2025-06-11
ER

PT J
AU Thumann, BF
   Börnhorst, C
   Ahrens, W
   Arvidsson, L
   Gwozdz, W
   Iguacel, I
   Mårild, S
   Molnar, D
   Rach, S
   Russo, P
   Tornaritis, M
   Veidebaum, T
   De Henauw, S
   Michels, N
AF Thumann, Barbara F.
   Boernhorst, Claudia
   Ahrens, Wolfgang
   Arvidsson, Louise
   Gwozdz, Wencke
   Iguacel, Isabel
   Marild, Staffan
   Molnar, Denes
   Rach, Stefan
   Russo, Paola
   Tornaritis, Michael
   Veidebaum, Toomas
   De Henauw, Stefaan
   Michels, Nathalie
CA IDEFICS & I Family Consortia
TI Cross-Sectional and Longitudinal Associations Between Psychosocial
   Well-Being and Cardiometabolic Markers in European Children and
   Adolescents
SO PSYCHOSOMATIC MEDICINE
LA English
DT Article
DE obesity; overweight; blood lipids; metabolic syndrome
ID METABOLIC SYNDROME; CHILDHOOD OBESITY; BLOOD-PRESSURE; CONSUMPTION
   FREQUENCIES; CARDIOVASCULAR RISK; BODY-COMPOSITION; REFERENCE VALUES;
   MENTAL-HEALTH; INSULIN; STRESS
AB Objective: Research examining aspects of positive mental health as potential predictors of cardiometabolic health in young populations is scarce. We investigated the associations between psychosocial well-being and waist circumference (WAIST), blood pressure (BP), the homeostasis model assessment for insulin resistance, triglycerides, and high-density lipoprotein cholesterol considering life-style factors as mediators.
   Methods: Data of European children and adolescents participating in the baseline (2007/2008), first follow-up (FU1; 2009/2010) and second follow-up (FU2; 2013/2014) examinations of the IDEFICS/I.Family study were used (n(cross-sectional) = 6519;n(longitudinal) = 1393). A psychosocial well-being score was calculated from 16 items on emotional well-being, self-esteem, and social relationships (0-48 points). Cardiometabolic markers were transformed to age- and sex-specific and, in case of BP, also height-specificzscores. Life-style factors included diet, physical activity, sleep, and electronic media use. Applying path analysis, we obtained unstandardized estimates of direct and indirect effects of well-being on cardiometabolic markers.
   Results: Cross-sectionally, well-being score showed a negative direct and a negative indirect effect through life-style factors on WAISTzscore (estimate per 4-point increase, -0.051 [p = .001] and -0.014 [p < .001], respectively). Longitudinally, positive changes in well-being score between baseline and FU1 and between FU1 and FU2, respectively, demonstrated negative indirect effects through life-style factors(FU2) on WAIST z score(FU2). Both cross-sectionally and longitudinally, higher levels of well-being showed lowering indirect effects on homeostasis model assessment, BP, and triglyceridezscores and an increasing indirect effect on high-density lipoprotein cholesterolzscore through both life-style factors and WAISTzscore.
   Conclusions: These results supported our hypothesis that a healthier life-style may be one mechanism through which higher well-being is linked with lower abdominal obesity and fewer other cardiometabolic disorders in young populations.
C1 [Thumann, Barbara F.; Boernhorst, Claudia; Ahrens, Wolfgang; Rach, Stefan] Leibniz Inst Prevent Res & Epidemiol BIPS, Achterstr 30, D-28359 Bremen, Germany.
   [Thumann, Barbara F.; Ahrens, Wolfgang] Univ Bremen, Fac Math & Comp Sci, Bremen, Germany.
   [Thumann, Barbara F.; De Henauw, Stefaan; Michels, Nathalie] Univ Ghent, Fac Med & Hlth Sci, Dept Publ Hlth & Primary Care, Ghent, Belgium.
   [Arvidsson, Louise] Univ Gothenburg, Sahlgrenska Acad, Sect Epidemiol & Social Med EPSO, Gothenburg, Sweden.
   [Gwozdz, Wencke] Copenhagen Business Sch, Frederiksberg, Denmark.
   [Gwozdz, Wencke] Justus Liebig Univ Giessen, Giessen, Germany.
   [Iguacel, Isabel] Univ Zaragoza, Fac Hlth Sci, GENUD Growth Exercise NUtr & Dev Res Grp, Zaragoza, Spain.
   [Marild, Staffan] Univ Gothenburg, Sahlgrenska Acad, Queen Silvia Childrens Hosp, Inst Clin Sci,Dept Pediat, Gothenburg, Sweden.
   [Molnar, Denes] Univ Pecs, Med Sch, Dept Paediat, Pecs, Hungary.
   [Russo, Paola] CNR, Inst Food Sci, Avellino, Italy.
   [Tornaritis, Michael] Res & Educ Inst Child Hlth, Strovolos, Cyprus.
   [Veidebaum, Toomas] Natl Inst Hlth Dev, Dept Chron Dis, Tallinn, Estonia.
C3 Leibniz Association; Leibniz Institute for Prevention Research &
   Epidemiology (BIPS); University of Bremen; Ghent University; Ghent
   University Hospital; University of Gothenburg; Copenhagen Business
   School; Justus Liebig University Giessen; University of Zaragoza;
   University of Gothenburg; Queen Silvia Children's Hospital; University
   of Pecs; Consiglio Nazionale delle Ricerche (CNR); Istituto di Scienze
   dell' Alimentazione (ISA-CNR); National Institute for Health Development
   - Estonia
RP Ahrens, W (corresponding author), Leibniz Inst Prevent Res & Epidemiol BIPS, Achterstr 30, D-28359 Bremen, Germany.
EM ahrens@leibniz-bips.de
RI Molnár, Dénes/AAB-6820-2022; Michels, Nathalie/C-2819-2012; Iguacel
   Azorín, Isabel/ABC-7789-2021
OI Iguacel, Isabel/0000-0003-4242-5464; Rach, Stefan/0000-0001-5241-0253;
   Michels, Nathalie/0000-0002-3069-7254; Thumann,
   Barbara/0000-0001-8145-5936; Gwozdz, Wencke/0000-0001-7176-708X
FU European Commission within the Sixth RTD Framework Program [016181];
   European Commission within the Seventh RTD Framework Program [266044]
FX This work was done as part of the IDEFICS (http://www.idefics.eu) and
   I.Family studies (http://www.ifamilystudy.eu/).We gratefully acknowledge
   the financial support of the European Commission within the Sixth RTD
   Framework Program Contract No. 016181 (FOOD) and the Seventh RTD
   Framework Program Contract No. 266044. The authors declare no competing
   interests.
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NR 51
TC 6
Z9 6
U1 0
U2 19
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0033-3174
EI 1534-7796
J9 PSYCHOSOM MED
JI Psychosom. Med.
PD OCT
PY 2020
VL 82
IS 8
BP 764
EP 773
DI 10.1097/PSY.0000000000000845
PG 10
WC Psychiatry; Psychology; Psychology, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry; Psychology
GA NX3MJ
UT WOS:000575616100005
PM 33009293
DA 2025-06-11
ER

PT J
AU Monin, JK
   Sperduto, CM
   Manigault, AW
   Dutton, A
   Clark, MS
   Jastreboff, AM
AF Monin, Joan K.
   Sperduto, Christina Maria
   Manigault, Andrew Wilhelm
   Dutton, Anne
   Clark, Margaret S.
   Jastreboff, Ania M.
TI Mindfulnes-Based Stress Reduction for Older Couples with Metabolic
   Syndrome: a Pilot Randomized Controlled Trial
SO MINDFULNESS
LA English
DT Article
DE MBSR; Couples; Metabolic syndrome
ID CARDIOVASCULAR-DISEASE; INTERVENTIONS; HEALTH; RISK; METAANALYSIS;
   INVENTORY; GENDER
AB Objective We examined the feasibility and explored the physical, psychological, relational, and biological effects of Mindfulness-Based Stress Reduction (MBSR), an 8-week standardized mindfulness program, involving older married couples (60 years or older) with metabolic syndrome (one or both partners had metabolic syndrome). We also explored gender differences. Methods A pilot randomized controlled trial (RCT) compared MBSR to a Wait List Control (WLC) arm at baseline, post-intervention, and 3-month follow-up clinic visits. Twenty-two spouses (11 couples) self-reported stress, physical and mental functioning, mindfulness, and relationship satisfaction at each time point. Fasting glucose, cholesterol, triglycerides, blood pressure, weight, and waist circumference were measured. MBSR couples answered questions about partner influences on participation, adherence, and practice at the post-intervention visit. Results In terms of adherence to MBSR sessions, four of the six couples attended all ten sessions; one couple attended 7; and one wife attended 6 and her husband attended 5 sessions. In terms of efficacy, there were no significant intervention effects; however, there were significant gender by intervention effects. Pre- to post-intervention, MBSR wives displayed greater increases in physical functioning (beta = 1.18, t(36) = 3.17, p = .003) and relationship satisfaction (beta = .72, t(36) = 2.81, p = .007) than WLC wives. Effects for husbands were not significant. Qualitatively, participants reported encouragement and increased relationship closeness. Conclusions Engaging in MBSR as a couple to address symptoms of metabolic syndrome was well-received and feasible. Preliminary effects suggest more benefits for wives than husbands in terms of physical functioning and relational well-being.
C1 [Monin, Joan K.; Sperduto, Christina Maria] Yale Sch Publ Hlth, Dept Social & Behav Sci, 60 Coll St, New Haven, CT 06520 USA.
   [Manigault, Andrew Wilhelm; Clark, Margaret S.] Ohio Univ, Dept Psychol, Athens, OH 45701 USA.
   [Dutton, Anne] Yale Sch Med, Dept Psychiat, New Haven, CT USA.
   [Jastreboff, Ania M.] Yale Sch Med, Pediat Pediat Endocrinol, New Haven, CT USA.
   [Jastreboff, Ania M.] Yale Sch Med, Internal Med Endocrinol & Metab, New Haven, CT USA.
C3 Yale University; University System of Ohio; Ohio University; Yale
   University; Yale University; Yale University
RP Monin, JK (corresponding author), Yale Sch Publ Hlth, Dept Social & Behav Sci, 60 Coll St, New Haven, CT 06520 USA.
EM joan.monin@yale.edu
OI Manigault, Andrew/0000-0003-4197-1295; Monin, Joan/0000-0002-1729-0230
FU NCATS NIH HHS [UL1 TR001863] Funding Source: Medline; NIA NIH HHS [T32
   AG019134, P30 AG021342] Funding Source: Medline
CR Aging, 2018, 2017 OLDER AM PROFIL
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NR 32
TC 7
Z9 9
U1 0
U2 19
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1868-8527
EI 1868-8535
J9 MINDFULNESS
JI Mindfulness
PD APR
PY 2020
VL 11
IS 4
BP 917
EP 927
DI 10.1007/s12671-019-01301-9
PG 11
WC Psychology, Clinical; Psychiatry
WE Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA KV3ZT
UT WOS:000520422900008
PM 33343762
OA Green Accepted
DA 2025-06-11
ER

PT J
AU de Azevedo, FR
   Ikeoka, D
   Caramelli, B
AF de Azevedo, Fernanda Reis
   Ikeoka, Dimas
   Caramelli, Bruno
TI Effects of intermittent fasting on metabolism in men
SO REVISTA DA ASSOCIACAO MEDICA BRASILEIRA
LA English
DT Review
DE Fasting; Cardiovascular diseases; Obesity; Metabolic syndrome X; Caloric
   restriction; Dyslipidemia
ID CORONARY-ARTERY-DISEASE; DAY CALORIE RESTRICTION; DIETARY RESTRICTION;
   INSULIN-RESISTANCE; ADIPONECTIN LEVELS; ADIPOSE-TISSUE; RISK-FACTORS;
   OBESITY; IMPROVES; INFLAMMATION
AB This review analyzes the available literature on the impact of intermittent fasting (IF), a nutritional intervention, on different aspects of metabolism. The epidemic of metabolic disturbances, such as obesity, metabolic syndrome (MS), and diabetes mellitus type 2 has led to an increase in the prevalence of cardiovascular diseases, and affected patients might significantly benefit from modifications in nutritional habits. Recent experimental studies have elucidated some of the metabolic mechanisms involved with IF. Animal models have shown positive changes in glucose (lower plasma glucose and insulin levels) and in lipid metabolism (reduced visceral fat tissue and increased plasma adiponectin level), and an increased resistance to stress. Despite the limited number of samples studied, positive results have been reported on the impact of IF for human health. IF is reported to improve the lipid profile; to decrease inflammatory responses, reflected by changes in serum adipokine levels; and to change the expression of genes related to inflammatory response and other factors. Studies on obese individuals have shown that patient compliance was greater for IF than other traditional nutritional approaches (calorie restriction), and IF was found to be associated with low oxidative stress. Recent reports suggest that IF exerts a positive impact on the metabolic derangements commonly associated with cardiovascular diseases, and that it may be a viable and accessible intervention for most individuals. Therefore, further clinical studies are essential to test the effectiveness of IF in preventing and controlling metabolic and cardiovascular diseases. (C) 2013 Elsevier Editora Ltda. All rights reserved.
C1 [de Azevedo, Fernanda Reis; Caramelli, Bruno] Univ Sao Paulo, Sch Med, Heart Inst InCor, Interdisciplinary Med Cardiol Unit, Sao Paulo, Brazil.
   [Ikeoka, Dimas] Univ Sao Paulo, Sch Med, Dept Surg 2, Postoperat Care Unit, Sao Paulo, Brazil.
C3 Universidade de Sao Paulo; Universidade de Sao Paulo
RP de Azevedo, FR (corresponding author), Heart Inst InCor, Interdisciplinary Med Cardiol Unit, Av Dr Eneas de Carvalho Aguiar 44, BR-05403000 Sao Paulo, Brazil.
EM freis@usp.br
RI Caramelli, Bruno/B-9916-2008; Ikeoka, Dimas/I-3298-2013
OI Ikeoka, Dimas/0000-0002-8776-9650; , Dimas/0000-0001-6770-3964
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NR 46
TC 38
Z9 43
U1 0
U2 97
PU ASSOC MEDICA BRASILEIRA
PI SAO PAULO
PA RUA SAO CARLOS DO PINHAL 324, CAIXA POSTAL 8904, SAO PAULO, SP, BRAZIL
EI 1806-9282
J9 REV ASSOC MED BRAS
JI Rev. Assoc. Med. Bras.
PD MAR-APR
PY 2013
VL 59
IS 2
BP 167
EP 173
DI 10.1016/S2255-4823(13)70451-X
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 127KU
UT WOS:000317698700016
PM 23582559
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Kohorst, JJ
   Kimball, AB
   Davis, MDP
AF Kohorst, John J.
   Kimball, Alexa B.
   Davis, Mark D. P.
TI Systemic associations of hidradenitis suppurativa
SO JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
LA English
DT Article
DE acne inversa; arthritis; depression; disease associations; hidradenitis
   suppurativa; inflammatory bowel disease; metabolic syndrome; smoking;
   spondyloarthropathy
ID FOLLICULAR OCCLUSION TRIAD; PYODERMA-GANGRENOSUM; ACNE CONGLOBATA;
   AUTOINFLAMMATORY SYNDROME; METABOLIC SYNDROME; DISEASE SEVERITY;
   ARTHRITIS; SPONDYLOARTHRITIS; COMORBIDITIES; PREVALENCE
AB Hidradenitis suppurativa (HS) is a progressive, inflammatory disease that affects mostly young women and appears to be caused by inflammation of hair follicles in areas of friction in the body (eg, the axillae, groin, perineum, and medial aspects of the thighs). Given this pathophysiology, one might expect comorbidities that contribute to inflammation and friction. Observed comorbidities fall into several categories: obesity and the metabolic syndrome, hormone-related disorders, deleterious health habits and mood, autoimmune disease, inflammatory disease and finally, the risk of skin cancer and sequelae of nonhealing wounds. The available literature on comorbid diseases of HS is limited but rapidly increasing. In this review, we summarize recent and major studies of HS disease association.
C1 [Kohorst, John J.] Mayo Clin, Coll Med, Rochester, MN 55905 USA.
   [Kimball, Alexa B.] Massachusetts Gen Hosp, Dept Dermatol, Boston, MA 02114 USA.
   [Kimball, Alexa B.] Harvard Univ, Sch Med, Boston, MA USA.
   [Davis, Mark D. P.] Mayo Clin, Dept Dermatol, Rochester, MN 55905 USA.
C3 Mayo Clinic; Harvard University; Harvard University Medical Affiliates;
   Massachusetts General Hospital; Harvard University; Harvard Medical
   School; Mayo Clinic
RP Davis, MDP (corresponding author), Mayo Clin, Dept Dermatol, 200 First St SW, Rochester, MN 55905 USA.
EM davis.mark2@mayo.edu
RI Kimball, Alexandra/M-6347-2019
OI Kimball, Alexandra/0000-0001-9405-0479; Kohorst,
   John/0000-0002-0722-3405
FU AbbVie Corporation
FX This publication was supported through funding provided by AbbVie
   Corporation.
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   Yadav S., Clin Gastroenterol Hepatol
NR 53
TC 106
Z9 107
U1 1
U2 9
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0190-9622
J9 J AM ACAD DERMATOL
JI J. Am. Acad. Dermatol.
PD NOV
PY 2015
VL 73
IS 5
SU 1
BP S27
EP S35
DI 10.1016/j.jaad.2015.07.055
PG 9
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA CU4IE
UT WOS:000363490300008
PM 26470611
DA 2025-06-11
ER

PT J
AU Jahangiry, L
   Shojaeizadeh, D
   Montazeri, A
   Najafi, M
   Mohammad, K
   Yaseri, M
AF Jahangiry, Leila
   Shojaeizadeh, Davoud
   Montazeri, Ali
   Najafi, Mahdi
   Mohammad, Kazem
   Yaseri, Mehdi
TI Adherence and Attrition in a Web-Based Lifestyle Intervention for People
   with Metabolic Syndrome
SO IRANIAN JOURNAL OF PUBLIC HEALTH
LA English
DT Article
DE Web-based intervention; Metabolic syndrome; Attrition; Adherence; R
   controlled trial
ID WAIST CIRCUMFERENCE; NONCOMMUNICABLE DISEASES; NATIONAL-SURVEY; IRANIAN
   ADULTS; CUTOFF POINTS; RISK-FACTORS; DEPRESSION; PREVALENCE; PROGRAM;
   WEIGHT
AB Background: The aim of this study was to determine adherence and attrition rates in a lifestyle intervention for people with metabolic syndrome.
   Methods: Adherence and attrition data from a randomized controlled trial were collected. Participants were classified as adherence group if they completed assessments at 3 and 6 months follow-up and as attrition group if they did not. Physical activity and quality of life was measured using the International Physical Activity Questionnaire (IPAQ) and the Short Form Health Survey (SF-36). Generalized Estimating Equations (GEE) was used to explore predictors of attrition.
   Results: The mean age of participants (n=160) was 44.1 years. Attrition rate in the intervention and control groups at first follow-up were the same (20%). However, the control group had significantly higher attrition rate (% 33.7) compared to the intervention group (% 20) at 6 months follow up. Results showed that low educated participants were more likely to not stay in the study than better educated participants (OR=2.95, CI: 1.39-6.33, P=0.05). According with length of the study, attrition was decreased at six month (OR=0.66, CI: 0.52-0.83, P<0.001). Also, some aspects of health-related quality of life contributed to the attrition rate. Those who had higher scores on general health (OR=0.66, CI: 0.54-0.97, P=0.023), social functioning (OR=0.44, CI: 0.40-0.76, P=0.032), role emotional (OR=0.74, CI: 0.54-0.98, P=0.18), vitality (OR=0.55, CI: 0.38-0.90, P=0.015) and mental health (OR=0.63, CI: 0.450.85, P=0.033) were more likely to stay in the study.
   Conclusion: It remains a concern that Web-based lifestyle programs may fail to reach those who need it most. Participant in the study generally had better quality of life than those who were lost to follow up.
C1 [Jahangiry, Leila] Tabriz Univ Med Sci, Sch Publ Hlth, Dept Hlth Educ & Hlth Promot, Tabriz, Iran.
   [Shojaeizadeh, Davoud] Univ Tehran Med Sci, Sch Publ Hlth, Dept Hlth Educ & Hlth Promot, Tehran, Iran.
   [Montazeri, Ali] ACECR, Iranian Inst Hlth Sci Res, Hlth Metr Res Ctr, Mental Hlth Res Grp, Tehran, Iran.
   [Najafi, Mahdi] Univ Tehran Med Sci, Tehran Heart Ctr, Tehran, Iran.
   [Mohammad, Kazem; Yaseri, Mehdi] Univ Tehran Med Sci, Sch Publ Hlth, Dept Epidemiol & Biostat, Tehran, Iran.
C3 Tabriz University of Medical Science; Tehran University of Medical
   Sciences; Academic Center for Education, Culture & Research (ACECR);
   Tehran University of Medical Sciences; Tehran University of Medical
   Sciences
RP Shojaeizadeh, D (corresponding author), Univ Tehran Med Sci, Sch Publ Hlth, Dept Hlth Educ & Hlth Promot, Tehran, Iran.
EM Shojae5@yahoo.com
RI Montazeri, Ali/C-9276-2009; Menezes, Ana/G-7266-2012; Jahangiry,
   Leila/F-9880-2017; Yaseri, Mehdi/I-1645-2018
OI Jahangiry, Leila/0000-0002-0491-5764; Montazeri,
   Ali/0000-0002-5198-9539; Yaseri, Mehdi/0000-0002-4066-873X
FU Iranian Institute for Health Sciences Research (ACECR)
FX This manuscript originated from a PhD thesis (240\2425) by Leila
   Jahangiry, Department of Health Education and Promotion, School of
   Public Health, Tehran University of Medical Sciences, Tehran, Iran. We
   acknowledge the contributions of Tehran Heart Center for providing
   facilities to the study. We wish to thank the Iranian Institute for
   Health Sciences Research (ACECR) for their time and support for this
   research. The authors declare that there is no conflict of interests.
CR Aalbers T, 2011, AGEING RES REV, V10, P487, DOI 10.1016/j.arr.2011.05.001
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   [Anonymous], HLTH TECHNOL ASSESS
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NR 32
TC 21
Z9 21
U1 0
U2 6
PU IRANIAN SCIENTIFIC SOCIETY MEDICAL ENTOMOLOGY
PI TEHRAN
PA SCHOOL PUBLIC HEALTH & INST HEALTH RESEARCH, TEHRAN UNIV MEDICAL
   SCIENCES, P O BOX  6446-14155, TEHRAN, 00000, IRAN
SN 2251-6085
EI 2251-6093
J9 IRAN J PUBLIC HEALTH
JI Iran J. Public Health
PD SEP
PY 2014
VL 43
IS 9
BP 1248
EP 1258
PG 11
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA AQ4GW
UT WOS:000342752700010
PM 26175979
DA 2025-06-11
ER

PT J
AU Park, S
   Joo, YH
   McIntyre, RS
   Kim, B
AF Park, Soyeon
   Joo, Yeon Ho
   McIntyre, Roger S.
   Kim, Byungsu
TI Metabolic Syndrome and Elevated C-Reactive Protein Levels in Elderly
   Patients With Newly Diagnosed Depression
SO PSYCHOSOMATICS
LA English
DT Article
ID CARDIOVASCULAR-DISEASE; ABDOMINAL OBESITY; MYOCARDIAL-INFARCTION;
   INSULIN SENSITIVITY; INCIDENT DEPRESSION; NATIONAL-HEALTH; OLDER-PEOPLE;
   US ADULTS; SYMPTOMS; INFLAMMATION
AB Background: Depression and metabolic syndrome (MeS) are prevalent in elderly people and are associated with adverse outcomes., especially cardiovascular disease. Increased C-reactive protein (CRP) levels are a risk factor for depression and chronic medical disorders', such as cardiovascular disease and MeS. Objective: The aim of this study was to evaluate the risk of MeS and CRP levels in elderly (>60 y) patients with newly-diagnosed major depressive disorder. Methods: We enrolled 30 subjects with newly diagnosed depression and 30 age-and sex-matched controls who presented for a health examination at Asan Medical Center, Seoul, Korea. Sociodemographic, MeS components, and CRP were measured Wore starting treatment with antidepressants. Results: There were no significant differences in sociodemographic characteristics or lifestyle factors between depressive and healthy control patients. The newly-diagnosed depression group showed a significantly increased risk of MeS (odds ratio = 4.75, 95% CI: 1.58-14.25) compared with the control group. Of the 5 MeS components examined, only waist circumference was significantly different between the 2 groups (odds ratio = 4.33, 95% CI: 1.20-15.61). Elevated CRP levels were significantly associated with an increased risk for depression (odds ratio = 4.57, 95% 1.45-14.39). Conclusions: The risks of MeS and elevated CRP levels are higher in elderly patients with depression than in normal subjects. Physicians need to be alert to these cardiovascular risk factors when diagnosing and prescribing antidepressants for depression in the elderly. Clinical investigators are encouraged to assess markers of inflammation and review detailed information on risk factors such as waist circumference for MeS in patients with depression.
C1 [Park, Soyeon; Joo, Yeon Ho; Kim, Byungsu] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Psychiat, 88 Olymp Ro 43 Gil, Seoul 136736, South Korea.
   [McIntyre, Roger S.] Univ Toronto, Univ Hlth Network, Mood Disorders Psychopharmacol Unit, Toronto, ON, Canada.
   [Kim, Byungsu] Asan Med Ctr, Hlth Promot Ctr, Stress Clin, Seoul, South Korea.
C3 University of Ulsan; Asan Medical Center; University of Toronto;
   University Health Network Toronto; University of Ulsan; Asan Medical
   Center
RP Kim, B (corresponding author), Univ Ulsan, Coll Med, Asan Med Ctr, Dept Psychiat, 88 Olymp Ro 43 Gil, Seoul 136736, South Korea.
EM j993601@empal.com
RI Kim, Byungsu/JNE-3151-2023; McIntyre, Roger/AAU-1000-2020
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   Zhao Guixiang, 2011, BMC Psychiatry, V11, P130, DOI 10.1186/1471-244X-11-130
NR 72
TC 12
Z9 13
U1 0
U2 8
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0033-3182
EI 1545-7206
J9 PSYCHOSOMATICS
JI Psychosomatics
PD NOV-DEC
PY 2014
VL 55
IS 6
BP 640
EP 649
DI 10.1016/j.psym.2013.12.010
PG 10
WC Psychiatry; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry; Psychology
GA AW3JG
UT WOS:000346182000014
PM 24629898
DA 2025-06-11
ER

PT J
AU Lam, JCM
   Mak, JCW
   Ip, MSM
AF Lam, Jamie Chung Mei
   Mak, Judith Choi Wo
   Ip, Mary Sau Man
TI Obesity, obstructive sleep apnoea and metabolic syndrome
SO RESPIROLOGY
LA English
DT Review
DE mechanistic pathway; metabolic syndrome; obesity; obstructive sleep
   apnoea
ID POSITIVE AIRWAY PRESSURE; C-REACTIVE PROTEIN; ACID-BINDING PROTEIN;
   PLASMA ADIPONECTIN LEVELS; FACTOR-KAPPA-B; INTERMITTENT HYPOXIA;
   INSULIN-RESISTANCE; WEIGHT-LOSS; CARDIOVASCULAR-DISEASE; OXIDATIVE
   STRESS
AB OSA is increasingly recognized as a major health problem in developed countries. Obesity is the most common risk factor in OSA and hence, the prevalence of OSA is undoubtedly rising given the epidemic of obesity. Recent data also suggest that OSA is highly associated with the metabolic syndrome, and it is postulated that OSA contributes to cardiometabolic dysfunction, and subsequently vasculopathy. Current evidence regarding the magnitude of impact on ultimate cardiovascular morbidity or mortality attributable to OSA-induced metabolic dysregulation is scarce. Given the known pathophysiological triggers of intermittent hypoxia and sleep fragmentation in OSA, the potential mechanisms of OSA-obesity-metabolic syndrome interaction involve sympathetic activation, oxidative stress, inflammation and neurohumoral changes. There is accumulating evidence from human and animal/cell models of intermittent hypoxia to map out these mechanistic pathways. In spite of support for an independent role of OSA in the contribution towards metabolic dysfunction, a healthy diet and appropriate lifestyle modifications towards better control of metabolic function are equally important as CPAP treatment in the holistic management of OSA.
C1 [Lam, Jamie Chung Mei; Mak, Judith Choi Wo; Ip, Mary Sau Man] Univ Hong Kong, Div Resp Med, Dept Med, Queen Mary Hosp, Hong Kong, Hong Kong, Peoples R China.
C3 University of Hong Kong
RP Ip, MSM (corresponding author), Univ Hong Kong, Div Resp Med, Dept Med, Queen Mary Hosp, Room 409,4-F,Professorial Block, Hong Kong, Hong Kong, Peoples R China.
EM msmip@hkucc.hku.hk
RI Mak, Judith/C-4363-2009; Ip, Mary Sau Man/C-4284-2009
OI Mak, Judith/0000-0002-8234-1313; Ip, Mary Sau Man/0000-0002-8692-6933
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NR 155
TC 129
Z9 143
U1 0
U2 13
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1323-7799
EI 1440-1843
J9 RESPIROLOGY
JI Respirology
PD FEB
PY 2012
VL 17
IS 2
BP 223
EP 236
DI 10.1111/j.1440-1843.2011.02081.x
PG 14
WC Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Respiratory System
GA 880OG
UT WOS:000299416100005
PM 21992649
OA Bronze
DA 2025-06-11
ER

PT J
AU Sánchez-Rodríguez, MA
   Martínez-Cruz, M
   Correa-Muñoz, E
   Mendoza-Núñez, VM
AF Sanchez-Rodriguez, Martha A.
   Martinez-Cruz, Mauricio
   Correa-Munoz, Elsa
   Manuel Mendoza-Nunez, Victor
TI Relationship between Metabolic Syndrome Components and Oxidative Stress
   in Elderly Community-Dwelling Mexicans
SO ANNALS OF NUTRITION AND METABOLISM
LA English
DT Article
DE Metabolic syndrome; Oxidative stress; Blood pressure; Elderly
ID RISK-FACTORS; BLOOD-PRESSURE; INFLAMMATION; PERSPECTIVE; PREVALENCE;
   BIOMARKERS; ADULTS; DAMAGE
AB Aim: To determine the relationship between metabolic syndrome (MetS) components and oxidative stress (OxS) in elderly community-dwelling Mexicans. Methods: We carried out a comparative cross-sectional study on 113 elderly subjects (>= 60 years old); 50 of them did not have MetS and 63 did have MetS (based on Adult Treatment Panel III criteria). We measured total antioxidant status (TAS), plasma lipid peroxidation (LPO), antioxidant activity of superoxide dismutase (SOD) and glutathione peroxidase (GPx), and calculated the SOD/GPx ratio. High blood pressure (HBP) was defined as systolic blood pressure (SBP) >= 140 mm Hg and/or diastolic blood pressure (DBP) >= 90 mm Hg. Results: We found a statistically significant increase in the percentage of cases of severe OxS in elderly subjects with MetS in comparison to healthy elderly (17 vs. 8%, OR: 7.33, 95% CI: 1.38-42.39; p < 0.01). It was observed that subjects with 5 MetS components had a 10-fold higher risk of developing OxS than subjects with 1 component (OR: 11.00, 95% CI: 1.72-115.17; p < 0.01). A positive correlation between SBP and LPO (r = 0.202, p < 0.05), and a negative correlation of SBP and DBP with TAS activity (r = -0.232, p < 0.05; r = -0.211, p < 0.05) were also observed. Conclusion: Our findings suggest that MetS is linked to severe OxS, that the number of metabolic syndrome components is a significant risk factor in the development of OxS, and that HBP is the most important metabolic syndrome component linked to OxS in the elderly. Copyright (C) 2010 S. Karger AG, Basel
C1 [Sanchez-Rodriguez, Martha A.; Martinez-Cruz, Mauricio; Correa-Munoz, Elsa; Manuel Mendoza-Nunez, Victor] Univ Nacl Autonoma Mexico, Fac Estudios Super Zaragoza, Unidad Invest Gerontol, Mexico City 04510, DF, Mexico.
C3 Universidad Nacional Autonoma de Mexico
RP Mendoza-Núñez, VM (corresponding author), Batalia 5 Mayo S-N, Mexico City 09230, DF, Mexico.
EM mendovic@servidor.unam.mx
RI Mendoza-Núñez, Víctor Manuel/AFL-2465-2022; Sanchez-Rodriguez,
   Martha/N-3528-2017
FU Direccion General de Asuntos del Personal Academico (DGAPA) of the
   Universidad Nacional Autonoma de Mexico (UNAM) [PAPIIT IN303407]
FX This work was supported by the Direccion General de Asuntos del Personal
   Academico (DGAPA) of the Universidad Nacional Autonoma de Mexico (UNAM);
   project PAPIIT IN303407.
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NR 25
TC 23
Z9 24
U1 0
U2 4
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0250-6807
EI 1421-9697
J9 ANN NUTR METAB
JI Ann. Nutr. Metab.
PD JUN
PY 2010
VL 56
IS 4
BP 302
EP 307
DI 10.1159/000309601
PG 6
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 618DG
UT WOS:000279331000010
PM 20530961
DA 2025-06-11
ER

PT J
AU Kiecolt-Glaser, JK
   Wilson, SJ
   Madison, A
AF Kiecolt-Glaser, Janice K.
   Wilson, Stephanie J.
   Madison, Annelise
TI Marriage and Gut (Microbiome) Feelings: Tracing Novel Dyadic Pathways to
   Accelerated Aging
SO PSYCHOSOMATIC MEDICINE
LA English
DT Review
DE gut dysbiosis; gut microbiota; health behaviors; immunosenescence;
   inflamm-aging; marriage; CRP = C-reactive protein; LBP = LPS-binding
   protein; LPS = lipopolysaccharide
ID HIGH-FAT MEALS; MARITAL CONFLICT; INFLAMMATORY RESPONSES; RELATIONSHIP
   QUALITY; METABOLIC-RESPONSES; PAST DEPRESSION; DAILY STRESSORS; SLEEP;
   COUPLES; HEALTH
AB Within a couple, partners influence each other's mental and physical health. This review focuses on how couples' relationships, the partners' individual and joint vulnerabilities, and their health behaviors influence health through changes in the gut microbiota, metabolism, and immune function. Couples' shared stressors and emotions and their intertwined lifestyles and routines serve to promote common disease risks in part through parallel changes in their gut microbiotas. Marital discord, stress, and depression have strong bidirectional links, fueling one another. Chronic marital stress and depression can elevate the risk for obesity, metabolic syndrome, and cardiovascular disease by altering resting energy expenditure, insulin production, and triglyceride responses after unhealthy meals. During stressful times, health behaviors typically suffer-and sleep disturbances, poor diets, and sedentary behavior all influence these metabolic pathways while also promoting gut dysbiosis. Dysbiosis increases intestinal permeability (gut leakiness), providing a mechanistic pathway from marital distress and depression to heightened inflammation and accelerated aging. Age-related changes in the gut microbiota's composition and gut leakiness foster immunosenescence, as well as the progression of inflamm-aging; these age-related risks may be altered by stress and depression, diet, sleep, exercise habits, and developmental shifts in emotion regulation strategies. Consideration of the strong mutual influences that partners have on each other's mood and health behaviors, as well as the biological pathways that underlie these influences, provides a new way to view marriage's health implications.
C1 [Kiecolt-Glaser, Janice K.; Wilson, Stephanie J.; Madison, Annelise] Ohio State Univ, Coll Med, Inst Behav Med Res, 460 Med Ctr Dr, Columbus, OH 43210 USA.
   [Kiecolt-Glaser, Janice K.] Ohio State Univ, Coll Med, Dept Psychiat & Behav Hlth, Columbus, OH 43210 USA.
   [Madison, Annelise] Ohio State Univ, Dept Psychol, Columbus, OH USA.
C3 University System of Ohio; Ohio State University; University System of
   Ohio; Ohio State University; University System of Ohio; Ohio State
   University
RP Kiecolt-Glaser, JK (corresponding author), Ohio State Univ, Coll Med, Inst Behav Med Res, 460 Med Ctr Dr, Columbus, OH 43210 USA.
EM Janice.Kiecolt-Glaser@osumc.edu
RI Kiecolt-Glaser, Janice/A-3236-2009
FU National Institutes of Health [K05 CA172296, R01 AG057032, K99 AG056667,
   T32 DE014320]
FX This study was supported in part by National Institutes of Health (Grant
   Number K05 CA172296, R01 AG057032, K99 AG056667, and T32 DE014320). The
   authors report no conflicts of interest.
CR [Anonymous], CELL HOST MICROBE
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NR 74
TC 29
Z9 31
U1 1
U2 17
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0033-3174
EI 1534-7796
J9 PSYCHOSOM MED
JI Psychosom. Med.
PD OCT
PY 2019
VL 81
IS 8
BP 704
EP 710
DI 10.1097/PSY.0000000000000647
PG 7
WC Psychiatry; Psychology; Psychology, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry; Psychology
GA KA9VO
UT WOS:000506148700004
PM 30308579
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Ban, MJ
   Kim, WS
   Park, KN
   Kim, JW
   Lee, SW
   Hans, K
   Chang, JW
   Byeon, HK
   Koh, YW
   Park, JH
AF Ban, Myung Jin
   Kim, Won Shik
   Park, Ki Nam
   Kim, Jae Wook
   Lee, Seung Won
   Hans, Kyungdo
   Chang, Jae Won
   Byeon, Hyung Kwon
   Koh, Yoon Woo
   Park, Jae Hong
TI Korean survey data reveals an association of chronic laryngitis with
   tinnitus in men
SO PLOS ONE
LA English
DT Article
ID GASTROESOPHAGEAL REFLUX DISEASE; METABOLIC SYNDROME; NERVE-STIMULATION;
   DISORDERS; INSOMNIA; APNEA; SLEEP
AB The association between chronic laryngitis and tinnitus is not a well- studied topic, unlike the association of these two conditions with many other disorders. Cross- sectional data of 11,347 adults (males: 4,934; females: 6,413), who completed the Korea National Health and Nutrition Examination Survey (KNHANES) from 2010 to 2012 were used to investigate this association. Lifestyle patterns, including smoking and alcohol habits, regular exercise, physical and mental health status, socioeconomic status, nutritional status, and other chronic diseases, were analyzed. Chronic laryngitis and tinnitus were diagnosed by field survey teams, which included otolaryngologists, who conducted chronic disease surveillance using a health status interview, a nutritional status questionnaire, and a physical examination. Chronic laryngitis was significantly associated with age, education beyond high school, depressed mood, voice change, metabolic syndrome, and tinnitus in men. In women, chronic laryngitis was associated with body mass index and diabetes mellitus. Chronic laryngitis in men was significantly associated with tinnitus (odds ratio 1.671, [95% confidence interval: 1.167 +/- 2.393]) after adjusting for age, body mass index, smoking status, alcohol intake, regular exercise, metabolic syndrome, education beyond high school, and depressed mood. Additionally, the prevalence of chronic laryngitis increased with increasing severity of tinnitus in men alone (P = 0.002). The study revealed a significant association between chronic laryngitis and tinnitus.
C1 [Ban, Myung Jin; Park, Jae Hong] Soonchunhyang Univ, Coll Med, Dept Otolaryngol Head & Neck Surg, Cheonan, South Korea.
   [Ban, Myung Jin] Yonsei Univ, Grad Sch, Dept Med, Seoul, South Korea.
   [Kim, Won Shik; Byeon, Hyung Kwon; Koh, Yoon Woo] Yonsei Univ, Coll Med, Dept Otorhinolaryngol, Seoul, South Korea.
   [Park, Ki Nam; Lee, Seung Won] Soonchunhyang Univ, Coll Med, Dept Otolaryngol Head & Neck Surg, Bucheon, South Korea.
   [Kim, Jae Wook] Soonchunhyang Univ, Coll Med, Dept Otolaryngol Head & Neck Surg, Seoul, South Korea.
   [Hans, Kyungdo] Catholic Univ Korea, Coll Med, Dept Biostat, Seoul, South Korea.
   [Chang, Jae Won] Chungnam Natl Univ, Coll Med, Dept Otorhinolaryngol, Daejeon, South Korea.
C3 Soonchunhyang University; Yonsei University; Yonsei University; Yonsei
   University Health System; Soonchunhyang University; Soonchunhyang
   University; Catholic University of Korea; Chungnam National University
RP Park, JH (corresponding author), Soonchunhyang Univ, Coll Med, Dept Otolaryngol Head & Neck Surg, Cheonan, South Korea.
EM entparkong@hanmail.net
RI Kim, Won/E-5403-2016; Lee, Eunkyung/AAG-1192-2019; Chang,
   Jae/R-3511-2019; Ban, Myung Jin/B-4619-2016
OI Chang, Jae Won/0000-0002-6596-931X; PARK, JAE HONG/0000-0002-5409-5581;
   Ban, Myung Jin/0000-0003-2069-2422; LEE, SEUNGWON/0000-0002-0468-8143
FU Soonchunhyang University Research Fund
FX This work was supported by the Soonchunhyang University Research Fund.
   (URL: http://sanhak.sch.ac.kr). The funder had no role in study design,
   data collection and analysis, decision to publish, or preparation of the
   manuscript.
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NR 30
TC 6
Z9 6
U1 2
U2 6
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JAN 11
PY 2018
VL 13
IS 1
AR e0191148
DI 10.1371/journal.pone.0191148
PG 12
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA FS7BJ
UT WOS:000419952400122
PM 29324903
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Fagiolini, A
   Frank, E
   Scott, JA
   Turkin, S
   Kupfer, DJ
AF Fagiolini, A
   Frank, E
   Scott, JA
   Turkin, S
   Kupfer, DJ
TI Metabolic syndrome in bipolar disorder: findings from the Bipolar
   Disorder Center for Pennsylvanians
SO BIPOLAR DISORDERS
LA English
DT Article
DE bipolar disorder; cholesterol; diabetes; metabolic syndrome; obesity;
   triglycerides
ID CORONARY-HEART-DISEASE; DIABETES-MELLITUS; CARDIOVASCULAR-DISEASE;
   INSULIN-RESISTANCE; WEIGHT CHANGE; PREVALENCE; OBESITY; DEPRESSION;
   HEALTH; CHOLESTEROL
AB Objective: This study sought to evaluate the presence of the metabolic syndrome in a group of 171 patients with bipolar disorder who were consecutively recruited in the Bipolar Disorder Center for Pennsylvanians.
   Methods: Data were collected from participants entering the Bipolar Disorder Center for Pennsylvanians protocol between 2003 and 2004. The study focused on the presence of the metabolic syndrome, as defined by the National Cholesterol Education Program Expert Panel on Detection, Evaluation And Treatment of High Blood Cholesterol in Adults (NCEP ATP III).
   Results: Thirty percent of the sample met the NCEP ATP III criterion for the metabolic syndrome, 49% met the criterion for abdominal obesity, 41% met the criterion for hypertriglyceridemia, 48% met the criterion for hypertriglyceridemia or were on a cholesterol-lowering medication, 23% met the criterion for low high-density lipoprotein cholesterol, 39% met the criterion for hypertension and 8% met the criterion for high fasting glucose or antidiabetic medication use. Patients with the metabolic syndrome and patients endorsing the obesity criterion were more likely (p = 0.05 and p = 0.004, respectively) to report a lifetime history of suicide attempt/s.
   Conclusion: The prevalence of the metabolic syndrome in patients with bipolar disorder is alarmingly high, as it is for the general population. The prevalence of obesity is even higher than the already very high prevalence that has been estimated for the US general population. Our findings are a reason for concern, considering the difficulty in implementing prevention and treatment programs in the bipolar population. We strongly support the development and testing of interventions specifically designed for preventing and treating the metabolic syndrome and its components in patients with bipolar disorder.
C1 Univ Pittsburgh, Sch Med, Western Psychiat Inst & Clin, Dept Psychiat, Pittsburgh, PA 15213 USA.
   Dubois Reg Med Ctr, Du Bois, PA USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE); University
   of Pittsburgh; Western Psychiatric Institute & Clinic of UPMC
RP Univ Pittsburgh, Sch Med, Western Psychiat Inst & Clin, Dept Psychiat, 3811 Ohara St, Pittsburgh, PA 15213 USA.
EM fagiolinia@upmc.edu
RI FAGIOLINI, ANDREA/T-2772-2017
OI FAGIOLINI, ANDREA/0000-0001-5827-0853; Scott, John/0000-0002-9116-948X
FU NIMH NIH HHS [MH30915] Funding Source: Medline
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NR 38
TC 378
Z9 404
U1 0
U2 17
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1398-5647
EI 1399-5618
J9 BIPOLAR DISORD
JI Bipolar Disord.
PD OCT
PY 2005
VL 7
IS 5
BP 424
EP 430
DI 10.1111/j.1399-5618.2005.00234.x
PG 7
WC Clinical Neurology; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA 965WD
UT WOS:000231980700004
PM 16176435
DA 2025-06-11
ER

PT J
AU Üstün, B
   Gerçik, E
AF Ustun, Besti
   Gercik, Esra
TI Self-care Power and Healthy Lifestyle Behaviors in Persons with Severe
   Mental Illness
SO MEDITERRANEAN NURSING AND MIDWIFERY
LA English
DT Article
DE Severe mental illness; healthy lifestyle behaviors; self-care power;
   community mental health center
ID PHYSICAL-ACTIVITY; METABOLIC SYNDROME; SCHIZOPHRENIA; EXERCISE; PROGRAM;
   FACILITATORS; INDIVIDUALS; EXPERIENCES; OUTPATIENTS; BARRIERS
AB Objective: The purpose of the study was to examine the self -care power and healthy lifestyle behaviors of persons with severe mental illness. Method: The research was carried out with 99 chronic psychiatric patients who applied to community mental health centres of one training and research hospital, two state hospitals. Data were collected using the healthy lifestyle behaviors scale II and the self -care power scale. Results: The highest level of healthy lifestyle behavior is in the dimensions of spiritual development and interpersonal relations, and the lowest level is in the dimension of physical activity. A moderately positive and significant relationship was found between the mean scores of healthy lifestyle behaviors and the mean scores of self -care power. Conclusion: In the study, the relationship between the healthy lifestyle behaviors of the patients and their self -care power was revealed. It is recommended that poor patients, young patients, and those with low social support should be evaluated as risky groups in terms of healthy lifestyle problems in community mental health centers and plans should be made to improve self -care power.
C1 [Ustun, Besti; Gercik, Esra] Istinye Univ, Fac Hlth Sci, Dept Nursing, Istanbul, Turkiye.
C3 Istinye University
RP Üstün, B (corresponding author), Istinye Univ, Fac Hlth Sci, Dept Nursing, Istanbul, Turkiye.
EM besti.ustun@istinye.edu.tr
RI Üstün, Besti/ABH-2879-2021
FX Funding: The authors declared that this study received no financial
   support.
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NR 50
TC 0
Z9 0
U1 1
U2 4
PU GALENOS PUBL HOUSE
PI ISTANBUL
PA Kacamak Sokak 21/1, ISTANBUL, Findikzade, TURKIYE
SN 2791-7940
J9 MEDITERR NURS MIDWIF
JI Mediterr. Nurs. Midwifery
PD DEC
PY 2023
VL 3
IS 3
BP 165
EP 173
DI 10.4274/MNM.2023.23152
PG 9
WC Nursing
WE Emerging Sources Citation Index (ESCI)
SC Nursing
GA XI1P5
UT WOS:001260964500008
OA gold
DA 2025-06-11
ER

PT J
AU Ion, A
   Dorobantu, AM
   Popa, LG
   Mihai, MM
   Orzan, OA
AF Ion, Ana
   Dorobantu, Alexandra Maria
   Popa, Liliana Gabriela
   Mihai, Mara Madalina
   Orzan, Olguta Anca
TI Risks of Biologic Therapy and the Importance of Multidisciplinary
   Approach for an Accurate Management of Patients with Moderate-Severe
   Psoriasis and Concomitant Diseases
SO BIOLOGY-BASEL
LA English
DT Review
DE chronic plaque psoriasis; biologic therapy risks; multidisciplinary
   approach
ID NECROSIS-FACTOR INHIBITORS; DOUBLE-BLIND; PLAQUE PSORIASIS;
   MONOCLONAL-ANTIBODY; CONTROLLED-TRIAL; HEPATITIS-B; OPEN-LABEL;
   PHASE-III; EFFICACY; PLACEBO
AB Simple Summary Psoriasis is a chronic multisystem inflammatory disease associated with a wide range of comorbidities including cardiovascular disease, hypertension, diabetes, hyperlipidemia, obesity, metabolic syndrome, anxiety, depression, chronic kidney disease, and malignancy. Currently available novel therapeutic options for moderate-severe psoriasis include tumor necrosis factor alpha inhibitors, inhibitors of the interleukin 17, and inhibitors of the interleukin 23. Apart from the concomitant diseases psoriasis patients may have, biologic therapy may cause significant complications requiring close collaboration between dermatologists and physicians of different specialties. Consequently, it was our main purpose to provide an overview of each class of biologic agents, as well as of the most frequent adverse events they may cause in psoriasis patients with concomitant diseases. Psoriasis is a chronic multisystem inflammatory disease associated with a plethora of comorbidities including metabolic syndrome, cardiovascular disease, hypertension, diabetes, hyperlipidemia, obesity, anxiety, depression, chronic kidney disease, and malignancy. Advancement in unveiling new key elements in the pathophysiology of psoriasis led to significant progress in the development of biologic agents which target different signaling pathways and cytokines involved in the inflammatory cascade responsible for the clinical manifestations found in psoriasis. Currently available novel therapeutic options for moderate-severe psoriasis include tumor necrosis factor alpha inhibitors, inhibitors of the interleukin 17, and inhibitors of the interleukin 23. Nevertheless, concerns have been raised with respect to the possible risks associated with the use of biologic therapy requiring close collaboration between dermatologists and physicians of different specialties. Our aim was to perform an in-depth literature review and discuss the potential risks associated with biologic therapy in patients with psoriasis and concurrent diseases with a focus on the influence of novel therapeutic agents on liver function in the context of hepatopathies, particularly viral hepatitis. A multidisciplinary teamwork and periodic evaluation of psoriasis patients under biologic therapy is highly encouraged to obtain an accurate management for each case.
C1 [Ion, Ana; Dorobantu, Alexandra Maria; Popa, Liliana Gabriela; Mihai, Mara Madalina; Orzan, Olguta Anca] Elias Emergency Univ Hosp, Dept Dermatol, Bucharest 011461, Romania.
   [Popa, Liliana Gabriela; Mihai, Mara Madalina; Orzan, Olguta Anca] Carol Davila Univ Med & Pharm, Bucharest 020021, Romania.
C3 Carol Davila University of Medicine & Pharmacy
RP Ion, A (corresponding author), Elias Emergency Univ Hosp, Dept Dermatol, Bucharest 011461, Romania.
EM anaion00@yahoo.com; alexandramdorobantu@gmail.com;
   liliana.popa@umfcd.ro; mara.mihai@umfcd.ro; olguta.orzan@umfcd.ro
RI Popa, Liliana/IWD-6082-2023; Mihai, Mara/K-1349-2014; Orzan,
   Olguta/JMC-6962-2023
OI Popa, Liliana Gabriela/0000-0002-1702-7280; Mihai,
   Mara/0000-0002-1436-0088; Ion, Ana/0000-0002-4214-4446; Dorobantu,
   Alexandra/0000-0002-7752-7930
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NR 79
TC 9
Z9 9
U1 1
U2 6
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2079-7737
J9 BIOLOGY-BASEL
JI Biology-Basel
PD JUN
PY 2022
VL 11
IS 6
AR 808
DI 10.3390/biology11060808
PG 17
WC Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics
GA 2K1WI
UT WOS:000816134100001
PM 35741329
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Rosengren, A
   Teo, K
   Rangarajan, S
   Kabali, C
   Khumalo, I
   Kutty, VR
   Gupta, R
   Yusuf, R
   Iqbal, R
   Ismail, N
   Altuntas, Y
   Kelishadi, R
   Diaz, R
   Avezum, A
   Chifamba, J
   Zatonska, K
   Wei, L
   Liao, X
   Lopez-Jaramillo, P
   Yusufali, A
   Seron, P
   Lear, SA
   Yusuf, S
AF Rosengren, A.
   Teo, K.
   Rangarajan, S.
   Kabali, C.
   Khumalo, I.
   Kutty, V. R.
   Gupta, R.
   Yusuf, R.
   Iqbal, R.
   Ismail, N.
   Altuntas, Y.
   Kelishadi, R.
   Diaz, R.
   Avezum, A.
   Chifamba, J.
   Zatonska, K.
   Wei, L.
   Liao, X.
   Lopez-Jaramillo, P.
   Yusufali, A.
   Seron, P.
   Lear, S. A.
   Yusuf, S.
TI Psychosocial factors and obesity in 17 high-, middle- and low-income
   countries: the Prospective Urban Rural Epidemiologic study
SO INTERNATIONAL JOURNAL OF OBESITY
LA English
DT Article
ID ACUTE MYOCARDIAL-INFARCTION; RISK-FACTORS; CARDIOVASCULAR-DISEASE;
   METABOLIC SYNDROME; STRESS; DEPRESSION; MEN; ASSOCIATION; INTERHEART;
   COMMUNITY
AB BACKGROUND/OBJECTIVES: Psychosocial stress has been proposed to contribute to obesity, particularly abdominal, or central obesity, through chronic activation of the neuroendocrine systems. However, these putative relationships are complex and dependent on country and cultural context. We investigated the association between psychosocial factors and general and abdominal obesity in the Prospective Urban Rural Epidemiologic study.
   SUBJECTS/METHODS: This observational, cross-sectional study enrolled 151 966 individuals aged 35-70 years from 628 urban and rural communities in 17 high-, middle- and low-income countries. Data were collected for 125 290 individuals regarding education, anthropometrics, hypertension/diabetes, tobacco/alcohol use, diet and psychosocial factors (self-perceived stress and depression).
   RESULTS: After standardization for age, sex, country income and urban/rural location, the proportion with obesity (body mass index. 30 kg m(-2)) increased from 15.7% in 40 831 individuals with no stress to 20.5% in 7720 individuals with permanent stress, with corresponding proportions for ethnicity-and sex-specific central obesity of 48.6% and 53.5%, respectively (P<0.0001 for both). Associations between stress and hypertension/diabetes tended to be inverse. Estimating the total effect of permanent stress with age, sex, physical activity, education and region as confounders, no relationship between stress and obesity persisted (adjusted prevalence ratio (PR) for obesity 1.04 (95% confidence interval: 0.99-1.10)). There was no relationship between ethnicity- and sex-specific central obesity (adjusted PR 1.00 (0.97-1.02)). Stratification by region yielded inconsistent associations. Depression was weakly but independently linked to obesity (PR 1.08 (1.04-1.12)), and very marginally to abdominal obesity (PR 1.01 (1.00-1.03)).
   CONCLUSIONS: Although individuals with permanent stress tended to be slightly more obese, there was no overall independent effect and no evidence that abdominal obesity or its consequences (hypertension, diabetes) increased with higher levels of stress or depression. This study does not support a causal link between psychosocial factors and abdominal obesity.
C1 [Rosengren, A.] Univ Gothenburg, Sahlgrenska Acad, Dept Mol & Clin Med, Gothenburg, Sweden.
   [Teo, K.; Rangarajan, S.; Kabali, C.; Yusuf, S.] McMaster Univ, Populat Hlth Res Inst, Hamilton, ON, Canada.
   [Teo, K.; Rangarajan, S.; Kabali, C.; Yusuf, S.] Hamilton Hlth Sci, Hamilton, ON, Canada.
   [Khumalo, I.] North West Univ, Optentia Res Programme, Fac Humanities, Vanderbilpark, South Africa.
   [Kutty, V. R.] Sree Chitra Tirunal Inst Med Sci & Technol, Achutha Menon Ctr Hlth Sci Studies, Trivandrum, Kerala, India.
   [Gupta, R.] Fortis Escorts Hosp, Jaipur, Rajasthan, India.
   [Yusuf, R.] Independent Univ Bangladesh, Dhaka, Bangladesh.
   [Iqbal, R.] Aga Khan Univ, Dept Community Hlth Sci & Med, Karachi, Pakistan.
   [Ismail, N.] Univ Kebangsaan, Dept Community Hlth, Kuala Lumpur, Malaysia.
   [Altuntas, Y.] Training & Res Hosp, SB Pediat Endocrinol & Metab, Istanbul, Turkey.
   [Kelishadi, R.] Isfahan Univ Med Sci, Cardiovasc Res Inst, Isfahan Cardiovasc Res Ctr, Esfahan, Iran.
   [Diaz, R.] Estudios Clin Latinoamer ECLA, Rosario, Santa Fe, Argentina.
   [Avezum, A.] Dante Pazzanese Inst Cardiol, Sao Paulo, Brazil.
   [Chifamba, J.] Univ Zimbabwe, Coll Hlth Sci, Dept Physiol, Harare, Zimbabwe.
   [Zatonska, K.] Med Univ Wroclaw, Dept Social Med, Wroclaw, Poland.
   [Wei, L.] Chinese Acad Med Sci, Natl Ctr Cardiovasc Dis, Fuwai Hosp, State Key Lab Cardiovasc Dis, Beijing 100730, Peoples R China.
   [Wei, L.] Peking Union Med Coll, Beijing 100021, Peoples R China.
   [Liao, X.] Sichuan Univ, West China Hosp, Chengdu 610064, Sichuan Provinc, Peoples R China.
   [Lopez-Jaramillo, P.] Fdn Oftalmol Santander FOSCAL, Santander, Colombia.
   [Lopez-Jaramillo, P.] Univ Santander UDES, Sch Med, Santander, Colombia.
   [Yusufali, A.] Dubai Hlth Author, Dubai, U Arab Emirates.
   [Seron, P.] Univ La Frontera, Temuco, Chile.
   [Lear, S. A.] Simon Fraser Univ, Fac Hlth Sci, Vancouver, BC, Canada.
   [Lear, S. A.] Providence Hlth Care, Div Cardiol, Vancouver, BC, Canada.
C3 University of Gothenburg; McMaster University; Population Health
   Research Institute; McMaster University; North West University - South
   Africa; Department of Science & Technology (India); Sree Chitra Tirunal
   Institute for Medical Sciences Technology (SCTIMST); Fortis Escorts
   Hospital; Independent University Bangladesh (IUB); Aga Khan University;
   Universiti Kebangsaan Malaysia; Mehmet Akif Ersoy Thoracic
   Cardiovascular Surgery Education Research Hospital; Isfahan University
   of Medical Sciences; Instituto Dante Pazzanese de Cardiologia;
   University of Zimbabwe; Wroclaw Medical University; Chinese Academy of
   Medical Sciences - Peking Union Medical College; Fu Wai Hospital - CAMS;
   Chinese Academy of Medical Sciences - Peking Union Medical College;
   Peking Union Medical College; Sichuan University; University of
   Santander; Universidad de La Frontera; Simon Fraser University
RP Rosengren, A (corresponding author), Univ Gothenburg, Sahlgrenska Acad, Dept Mol & Clin Med, Gothenburg, Sweden.
EM Annika.Rosengren@gu.se
RI Schmid, Helena/B-1886-2019; Kabali, Conrad/AAW-6681-2021; Mert,
   Meral/KXR-1439-2024; Gupta, Radhey'Shyam/LKK-6909-2024; Ismail,
   Noor/KIE-7635-2024; Avezum, Alvaro/AAP-7687-2020; Seron,
   Pamela/AAN-3304-2021; Zatońska, Katarzyna/ABD-4236-2021; Chifamba,
   Jephat/AHE-4535-2022; Yusuf, Suhaila/O-3005-2013; Kelishadi,
   Roya/E-6154-2012
OI Yusuf, Salim/0000-0003-4776-5601; Seron, Pamela/0000-0003-0190-8988;
   Yusufali, Afzalhussein/0000-0003-3378-2646; AVEZUM,
   ALVARO/0000-0002-3073-6890; Gupta, Rajeev/0000-0002-8356-3137;
   Kelishadi, Roya/0000-0001-7455-1495; Lopez-Jaramillo,
   Patricio/0000-0002-9122-8742; Zatonska, Katarzyna/0000-0002-3772-5588;
   Ismail, Noor Hassim/0000-0003-1547-7904; Rosengren,
   Annika/0000-0002-5409-6605; Teo, Koon/0000-0002-3731-0956; Chifamba,
   Jephat/0000-0001-8166-1182
FU FIC NIH HHS [R24 TW008893, R24 TW008905] Funding Source: Medline
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NR 38
TC 28
Z9 33
U1 0
U2 14
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0307-0565
EI 1476-5497
J9 INT J OBESITY
JI Int. J. Obes.
PD AUG
PY 2015
VL 39
IS 8
BP 1217
EP 1223
DI 10.1038/ijo.2015.48
PG 7
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA CR0BK
UT WOS:000360983000006
PM 25869608
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Shakeri, J
   Farnia, V
   Valinia, K
   Hashemian, AH
   Bajoghli, H
   Holsboer-Trachsler, E
   Brand, S
AF Shakeri, Jalal
   Farnia, Vahid
   Valinia, Katayoun
   Hashemian, Amir Hossein
   Bajoghli, Hafez
   Holsboer-Trachsler, Edith
   Brand, Serge
TI The relationship between lifetime suicide attempts, serum lipid levels,
   and metabolic syndrome in patients with bipolar disorders
SO INTERNATIONAL JOURNAL OF PSYCHIATRY IN CLINICAL PRACTICE
LA English
DT Article
DE Lifetime suicide attempts; bipolar disorder; metabolic syndrome; serum
   lipid profiles
ID CHOLESTEROL LEVELS; MAJOR DEPRESSION; BEHAVIOR; RISK; ASSOCIATION;
   COMORBIDITY
AB Objectives. To assess the relationship between lifetime suicide attempts (SAs), serum lipid values, and metabolic syndrome (MetS) in patients with bipolar disorders (BPD). Methods. Eighty patients with BPD took part in the study (M = 40.60 years). Aft er psychiatric diagnosis, demographic data, SAs, and serum lipids were measured and MetS was calculated. Results. 70% reported at least one suicide attempt. 52.5% suffered from MetS. Suicide attempters had higher cholesterol values. SAs were associated with a family history of suicide, current mood state, and lower educational level. SAs were unrelated to MetS. Conclusions. In patients with BPD, against expectations, the occurrence of SAs was associated with higher cholesterol values. Serum lipid values are not suitable as a biological trait marker to predict SAs.
C1 [Shakeri, Jalal; Farnia, Vahid] Kermanshah Univ Med Sci, Dept Psychiat, Behav Sci Res Ctr, Kermanshah, Iran.
   [Valinia, Katayoun] Kermanshah Univ Med Sci, Student Res Ctr, Kermanshah, Iran.
   [Hashemian, Amir Hossein] Kermanshah Univ Med Sci, Sch Publ Hlth, Dept Biostat & Epidemiol, Kermanshah, Iran.
   [Bajoghli, Hafez] Univ Tehran Med Sci, INCAS, Iranian Inst Reduct High Risk Behav, Tehran, Iran.
   [Bajoghli, Hafez] Mahidol Univ, ASEAN Inst Hlth Dev, Nakhornpathom, Thailand.
   [Holsboer-Trachsler, Edith; Brand, Serge] Univ Basel, Psychiat Clin, Ctr Affect Stress & Sleep Disorders, CH-4012 Basel, Switzerland.
   [Brand, Serge] Univ Basel, Div Sport Sci, Dept Exercise & Hlth Sci, Fac Med, CH-4012 Basel, Switzerland.
C3 Kermanshah University of Medical Sciences; Kermanshah University of
   Medical Sciences; Kermanshah University of Medical Sciences; Tehran
   University of Medical Sciences; Mahidol University; University of Basel;
   University of Basel; University of Geneva
RP Brand, S (corresponding author), Univ Basel, Psychiat Clin, Ctr Affect Stress & Sleep Disorders, Wilhelm Klein Str 27, CH-4012 Basel, Switzerland.
EM serge.brand@upkbs.ch
RI Hashemian, Amir/G-7947-2016; Shakeri, Jalal/P-5648-2017; Brand,
   Serge/H-7159-2019
OI Brand, Serge/0000-0003-2175-2765; Shakeri, Jalal/0000-0002-4753-2050;
   Hashemian, Amir Hossein/0000-0003-4742-6466
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NR 37
TC 21
Z9 21
U1 1
U2 9
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1365-1501
EI 1471-1788
J9 INT J PSYCHIAT CLIN
JI Int. J. Psychiat. Clin.
PD JUN
PY 2015
VL 19
IS 2
BP 124
EP 131
DI 10.3109/13651501.2014.988271
PG 8
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychiatry
GA CH7MK
UT WOS:000354220500009
PM 25410158
DA 2025-06-11
ER

PT J
AU Carney, R
   Imran, S
   Law, H
   Folstad, S
   Parker, S
AF Carney, Rebekah
   Imran, Shermin
   Law, Heather
   Folstad, Siri
   Parker, Sophie
TI Evaluation of the physical health of adolescent in-patients in generic
   and secure services: retrospective case-note review
SO BJPSYCH BULLETIN
LA English
DT Review
DE Adolescent; in-patient; secure services; mental health; physical health
ID SEVERE MENTAL-ILLNESS; ULTRA-HIGH RISK; METABOLIC SYNDROME;
   YOUNG-PEOPLE; LIFE-STYLE; SCHIZOPHRENIA; PREVALENCE; PSYCHOSIS;
   HYPERPROLACTINEMIA; ANTIPSYCHOTICS
AB Aims and method To assess physical health needs of adolescent in-patients by routine monitoring. A retrospective analysis of case notes was conducted on a 6-month intake to generic and secure adolescent mental health units in Greater Manchester, UK. Results Fifty individuals were admitted (52% female, average age 15.84 years). Diagnoses varied and 66% were prescribed medications before admission. All had a physical health assessment, which identified various physical health risk factors. Average body mass index was 25.99 (range 15.8-44), and increased during in-patient treatment for 84% of individuals who had their body mass recorded more than once. A total of 28% of individuals smoked. Lipids and prolactin levels were elevated across the sample. Clinical implications This evaluation strengthens the argument to optimise physical healthcare for adolescent in-patients and develop physical health interventions, particularly given that we observed elevated lipids and prolactin. Physical health and well-being may not be prioritised when assessing and managing young peoples' mental health, despite their increased vulnerability for comorbid conditions.
C1 [Carney, Rebekah; Law, Heather; Parker, Sophie] Greater Manchester Mental Hlth NHS Fdn Trust, Youth Mental Hlth Res Unit, Manchester, Lancs, England.
   [Carney, Rebekah; Folstad, Siri; Parker, Sophie] Univ Manchester, Fac Biol Med & Hlth, Manchester, Lancs, England.
   [Imran, Shermin] Greater Manchester Mental Hlth NHS Fdn Trust, Child & Adolescent Mental Hlth Serv, Manchester, Lancs, England.
C3 University of Manchester
RP Carney, R (corresponding author), Greater Manchester Mental Hlth NHS Fdn Trust, Youth Mental Hlth Res Unit, Manchester, Lancs, England.; Carney, R (corresponding author), Univ Manchester, Fac Biol Med & Hlth, Manchester, Lancs, England.
EM rebekah.carney@gmmh.nhs.uk
RI Carney, Rebekah/AAO-5205-2021
OI Parker, Sophie/0000-0001-5596-7524; Hausland Folstad,
   Siri/0000-0001-8008-5961; Carney, Rebekah/0000-0002-2859-6825
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NR 34
TC 5
Z9 5
U1 0
U2 0
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 2056-4694
EI 2056-4708
J9 BJPSYCH BULL
JI BJPsych Bull.
PD JUN
PY 2020
VL 44
IS 3
BP 95
EP 102
AR PII S2056469419000688
DI 10.1192/bjb.2019.68
PG 8
WC Psychiatry
WE Emerging Sources Citation Index (ESCI)
SC Psychiatry
GA LR8DN
UT WOS:000535926900003
PM 31679539
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU McDonell, MG
   Kaufman, EA
   Srebnik, DS
   Ciechanowski, PS
   Ries, RK
AF McDonell, Michael G.
   Kaufman, Erin A.
   Srebnik, Debra S.
   Ciechanowski, Paul S.
   Ries, Richard K.
TI BARRIERS TO METABOLIC CARE FOR ADULTS WITH SERIOUS MENTAL ILLNESS:
   PROVIDER PERSPECTIVES
SO INTERNATIONAL JOURNAL OF PSYCHIATRY IN MEDICINE
LA English
DT Article
DE metabolic syndrome; serious mental illness; primary care; primary care
   provider; barriers to care
ID MEDICAL-CARE; SCHIZOPHRENIA; ACCESS; TRIAL; RATES
AB This study assessed barriers to metabolic care for persons with serious mental illness (SMI) by surveying experienced healthcare providers. Sixty-eight medical, mental health, and other stakeholders who care for patients with SMI attended a CME conference focused on medical management of SMI patients in 2007. They completed a 27-item survey assessing barriers to and systemic responsibility for metabolic care. The top three ranked barriers were: "separate mental health and primary care systems," "patient's lack of resources," and "[ mental health] providers are not trained to do basic primary care." Results indicated that ratings of CMHC responsibility for SMI metabolic care (M = 5.2, SD = 1.5) were significantly lower than ratings of public health (M = 5.7, SD = 1.4), t(66) = 2.3, p = 0.027, and primary care providers (M = 6.3, SD = 1.1), t(67) = 4.7, p < 0.001. Experienced providers identified a lack of integrated care and patient characteristics as important barriers to metabolic care and concluded that the primary care and public health systems are primarily responsible for metabolic treatment. (Int'l. J. Psychiatry in Medicine 2011;41:379-387)
C1 [McDonell, Michael G.; Kaufman, Erin A.; Srebnik, Debra S.; Ciechanowski, Paul S.; Ries, Richard K.] Univ Washington, Sch Med, Seattle, WA USA.
C3 University of Washington; University of Washington Seattle
RP McDonell, MG (corresponding author), Box 359911 HMC,325 9th Ave, Seattle, WA 98104 USA.
EM mikemcd@uw.edu
RI Kaufman, Erin/AAI-6033-2020
OI Kaufman, Erin/0000-0002-7636-6602
CR [Anonymous], 2004, J CLIN PSYCHIAT, V65, P267
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   U.S. Department of Health and Human Services (US DHHS), 2005, SUBST AB TREATM PERS
NR 19
TC 17
Z9 18
U1 0
U2 6
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0091-2174
EI 1541-3527
J9 INT J PSYCHIAT MED
JI Int. J. Psychiatr. Med.
PY 2011
VL 41
IS 4
BP 379
EP 387
DI 10.2190/PM.41.4.g
PG 9
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 848DS
UT WOS:000297029800007
PM 22238842
DA 2025-06-11
ER

PT J
AU Fagiolini, A
AF Fagiolini, Andrea
TI Overcoming hurdles to achieving good physical health in patients treated
   with atypical antipsychotics
SO EUROPEAN NEUROPSYCHOPHARMACOLOGY
LA English
DT Article
DE atypical antipsychotics; schizophrenia; weight gain; dyshpidaemia;
   diabetes; metabolic syndrome
ID METABOLIC SYNDROME; SCHIZOPHRENIA TRIAL; OPEN-LABEL; CONSENSUS;
   ARIPIPRAZOLE; PREVALENCE; THERAPY; RISK
AB Hurdles that must be overcome in order to implement guidelines and maximize physical health in Weight gain; patients treated with antipsychotics include the impression that a disruption in physical health is Dyshpidaemia; an inevitable token for the patient to pay in order to achieve and maintain his or her mental Diabetes; health; lack of routine monitoring; lack of defined care pathways for evaluation, monitoring and Metabolic syndrome treatment of physical health issues in psychiatry; the burden of guideline implementation on mental health team resources; the difficulty to perform certain procedures (e.g. monitoring of waist circumference); and reluctance to switch medications once physical health effects are recognized, especially if the psychiatric symptoms are under relatively good control. It is imperative that we act now to overcome these hurdles and maximize outcomes for our patients. Strategies include establishing simple, consistent processes for physical health monitoring and tracking in clinical practice; provision of appropriate equipment to staff; effective education of all personnel involved in the care of psychiatric patients regarding this important topic; and consideration of a medication switch in patients whose medication is a high-risk contributory factor to poor physical health. (c) 2008 Elsevier B.V. and ECNP. All rights reserved.
C1 Univ Pittsburgh, Sch Med, Dept Psychiat, Western Psychiat Inst & Clin, Pittsburgh, PA 15213 USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE); University
   of Pittsburgh; Western Psychiatric Institute & Clinic of UPMC
RP Fagiolini, A (corresponding author), Univ Pittsburgh, Sch Med, Dept Psychiat, Western Psychiat Inst & Clin, 3811 OHara St, Pittsburgh, PA 15213 USA.
EM fagiolinia@upmc.edu
RI FAGIOLINI, ANDREA/T-2772-2017
OI FAGIOLINI, ANDREA/0000-0001-5827-0853
CR Amer Diabet Assoc, 2004, DIABETES CARE, V27, P596, DOI 10.2337/diacare.27.2.596
   Barnes TRE, 2007, SCHIZOPHRENIA BULL, V33, P1397, DOI 10.1093/schbul/sbm038
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NR 20
TC 5
Z9 6
U1 0
U2 9
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0924-977X
EI 1873-7862
J9 EUR NEUROPSYCHOPHARM
JI Eur. Neuropsychopharmacol.
PD MAY
PY 2008
VL 18
SU 2
BP S101
EP S107
DI 10.1016/j.euroneuro.2008.02.003
PG 7
WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA 289VA
UT WOS:000255080800002
PM 18346597
DA 2025-06-11
ER

PT J
AU Connolly, K
   Batacan, R Jr
   Jackson, D
   Fenning, AS
AF Connolly, Kylie
   Batacan Jr, Romeo
   Jackson, Douglas
   Fenning, Andrew Stuart
TI Effects of epicatechin on cardiovascular function in middle-aged
   diet-induced obese rat models of metabolic syndrome
SO BRITISH JOURNAL OF NUTRITION
LA English
DT Article
DE Epicatechin; Metabolic syndrome; Diet-induced obesity; CVD; High-fat
   high-carbohydrate diet
ID REDUCES BLOOD-PRESSURE; OXIDATIVE STRESS; INSULIN-RESISTANCE;
   (-)-EPICATECHIN; INFLAMMATION; (-)EPICATECHIN; INCREASE; EXTRACT
AB The current study aimed to investigate the cardiovascular effects of epicatechin, a flavonoid found in green tea and cocoa, in attenuating complications associated with metabolic syndrome in diet-induced obese rats. Male Wistar-Kyoto (WKY) rats aged 16 weeks were fed either standard rat chow or given a high-fat-high-carbohydrate (HFHC) diet for 20 weeks. Epicatechin treatment (5 mg/kg/d) was administered to a subset of WKY rats commencing at week 8 of the 20 week HFHC feeding period. Body weights, food, water and energy intakes, blood pressure, heart rate and glucose tolerance were measured throughout the treatment period. Oxidative stress and inflammatory markers, lipid levels, cardiac collagen deposition, cardiac electrical function, aortic and mesenteric vessel reactivity were examined after the treatment. Twenty weeks of HFHC feeding in WKY rats resulted in the development of metabolic syndrome indicated by the presence of abdominal obesity, dyslipidaemia, glucose intolerance and increased blood pressure. Epicatechin treatment was found to enhance the oxidative stress status in HFHC groups through an increase in serum nitric oxide levels and a decrease in 8-isoprostane concentrations. Furthermore, WKY-HFHC rats displayed a decrease in IL-6 levels. The lipid profiles in HFHC groups showed improvement, with a decrease in LDL-cholesterol and TAG and an increase in HDL-cholesterol levels observed in WKY-HFHC rats. However, epicatechin was not effective in preventing weight gain, glucose intolerance or hypertension in HFHC fed rats. Overall, the results of this study suggest that epicatechin has the potential to improve the underlying mechanisms associated with metabolic syndrome in obese rats.
C1 [Connolly, Kylie; Batacan Jr, Romeo; Fenning, Andrew Stuart] Cent Queensland Univ, Sch Hlth Med & Appl Sci, Bruce Highway, Rockhampton, Qld 4701, Australia.
   [Jackson, Douglas] Australian Catholic Univ, 40 Edward St, North Sydney, NSW 2060, Australia.
C3 Central Queensland University; Australian Catholic University;
   Australian Catholic University - North Sydney Campus
RP Batacan, R Jr (corresponding author), Cent Queensland Univ, Sch Hlth Med & Appl Sci, Bruce Highway, Rockhampton, Qld 4701, Australia.
OI Jackson, Douglas/0000-0003-4835-0467
FU The authors declare that there are no conflicts of interest.
FX K. C. was supported by a Scholarship from the Australian Government's
   Research Training Program/Research Training Scheme.r This research did
   not receive any specific grant from funding agencies in the public,
   commercial or not-for-profit sectors.r K. C: Conceptualisation, formal
   analysis, methodology, investigation, writing - original draft and
   reviewing and editing. R. B: Investigation, writing, reviewing and
   editing. D. J.: Investigation, reviewing and editing. A. S. F.:
   Supervision, methodology, investigation, writing, reviewing and
   editing.r The authors declare that there are no conflicts of interest.
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NR 37
TC 4
Z9 6
U1 2
U2 10
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1145
EI 1475-2662
J9 BRIT J NUTR
JI Br. J. Nutr.
PD FEB 28
PY 2024
VL 131
IS 4
BP 593
EP 605
DI 10.1017/S000711452300209X
EA SEP 2023
PG 13
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA FD4U6
UT WOS:001086541400001
PM 37732427
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Hwang, MH
   Yoo, JK
   Luttrell, M
   Meade, TH
   English, M
   Christou, DD
AF Hwang, Moon-Hyon
   Yoo, Jeung-Ki
   Luttrell, Meredith
   Meade, Thomas H.
   English, Mark
   Christou, Demetra. D.
TI Effect of Selective Mineralocorticoid Receptor Blockade on Flow-Mediated
   Dilation and Insulin Resistance in Older Adults with Metabolic Syndrome
SO METABOLIC SYNDROME AND RELATED DISORDERS
LA English
DT Article
ID ENDOTHELIAL FUNCTION; BRACHIAL-ARTERY; ALDOSTERONE; EPLERENONE;
   ATHEROSCLEROSIS; DYSFUNCTION; ANTAGONISM; GLUCOSE; STRESS; RISK
AB Background: The prevalence of metabolic syndrome is especially high in older adults. Metabolic syndrome is associated with impaired vascular endothelial function, insulin resistance, and increased risk for cardiovascular disease but the underlying mechanisms are not fully elucidated. Plasma aldosterone is independently associated with metabolic syndrome and is linked to endothelial dysfunction and insulin resistance. Thus, we hypothesized that mineralocorticoid receptor (MR) blockade would improve flow-mediated dilation and insulin resistance in older adults with metabolic syndrome. Methods: To test this hypothesis, we conducted a balanced, randomized, double-blind, placebo-controlled, crossover study using selective MR blockade (eplerenone; 100 mg/day) for 1 month with 1 month washout in older adults with metabolic syndrome (62.6 +/- 3.2 yrs; mean +/- standard error). We evaluated brachial artery flow-mediated dilation (ultrasonography), oxidative stress (oxidized low-density lipoproteins and F-2-isoprostanes) and insulin resistance (homeostatic model assessment). Results: In response to MR blockade, flow-mediated dilation (5.37 +/- 0.85 vs. 5.98 +/- 1.29%; placebo vs. eplerenone; P = 0.4), oxidized low-density lipoproteins (51.6 +/- 11.5 vs. 56.1 +/- 10.9 U/L; P = 0.6), and F-2-isoprostanes (0.07 +/- 0.02 vs. 0.06 +/- 0.01 pg/mL; P = 0.3) did not improve. Insulin resistance also did not change following MR blockade (1.04 +/- 0.26 vs. 1.38 +/- 0.50; P = 0.6). However, MR blockade resulted in a large reduction (10 mmHg) in systolic blood pressure (140 +/- 6 vs. 130 +/- 6 mmHg; P = 0.02), with no significant change in diastolic blood pressure (81 +/- 3 vs. 75 +/- 2 mmHg; P = 0.2). Conclusions: Our data do not support a contributing role for MRs in endothelial dysfunction and insulin resistance in older adults with metabolic syndrome. However, our findings suggest MR activation is an important contributor to systolic hypertension in this patient group.
C1 [Hwang, Moon-Hyon; Yoo, Jeung-Ki; Christou, Demetra. D.] Univ Florida, Dept Appl Physiol & Kinesiol, Gainesville, FL 32611 USA.
   [Hwang, Moon-Hyon] Incheon Natl Univ, Div Hlth & Exercise Sci, Inchon, South Korea.
   [Luttrell, Meredith] Univ Oregon, Dept Human Physiol, Eugene, OR 97403 USA.
   [Meade, Thomas H.] Texas A&M Univ, Baylor Scott & White Hlth, Dept Cardiol, College Stn, TX USA.
   [English, Mark] Texas A&M Univ, Baylor Scott & White Hlth, Dept Family & Community Med, College Stn, TX USA.
C3 State University System of Florida; University of Florida; Incheon
   National University; University of Oregon; Baylor Health Care System;
   Texas A&M University System; Texas A&M University College Station;
   Baylor Health Care System; Texas A&M University System; Texas A&M
   University College Station
RP Christou, DD (corresponding author), Univ Florida, Dept Appl Physiol & Kinesiol, 120 FLG Stadium Rd, Gainesville, FL 32611 USA.
EM ddchristou@ufl.edu
RI Luttrell, Meredith/AGK-5996-2022
OI Yoo, Jeung-Ki/0000-0003-1350-2491; Hwang, Moon-Hyon/0000-0001-6095-4349
FU National Institutes of Health [AG 032067]; American Heart Association
   [0865117F]; American Heart Association (AHA) [0865117F] Funding Source:
   American Heart Association (AHA)
FX This work was supported by the National Institutes of Health [grant AG
   032067] and American Heart Association [grant 0865117F] to Demetra
   Christou. The authors would like to thank Ms. Sharon Greer, RN, Mr.
   Creighton Wilson, RN, and the Division of Cardiology at the Scott and
   White Clinic at College Station, Texas, for their contributions. The
   authors would also like to thank Ms. Molly Cernosek for technical
   assistance and the study participants for their time and efforts.
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NR 32
TC 9
Z9 10
U1 0
U2 2
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-4196
EI 1557-8518
J9 METAB SYNDR RELAT D
JI Metab. Syndr. Relat. Disord.
PD OCT 1
PY 2015
VL 13
IS 8
BP 356
EP 361
DI 10.1089/met.2015.0044
PG 6
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA CR5PM
UT WOS:000361395600006
PM 26302093
OA Green Published
DA 2025-06-11
ER

PT J
AU Ruud, T
   Hoifodt, TS
   Hendrick, DC
   Drake, RE
   Hoye, A
   Landers, M
   Heiervang, KS
   Bond, GR
AF Ruud, Torleif
   Hoifodt, Tordis Sorensen
   Hendrick, Delia Cimpean
   Drake, Robert E.
   Hoye, Anne
   Landers, Matthew
   Heiervang, Kristin S.
   Bond, Gary R.
TI The Physical Health Care Fidelity Scale: Psychometric Properties
SO ADMINISTRATION AND POLICY IN MENTAL HEALTH AND MENTAL HEALTH SERVICES
   RESEARCH
LA English
DT Article
DE Psychoses; Physical health care; Evidence-based practice;
   Implementation; Fidelity scale
ID MAJOR DEPRESSIVE DISORDER; SEVERE MENTAL-ILLNESS; POOR ORAL-HEALTH;
   BIPOLAR DISORDER; CORRELATION-COEFFICIENTS; CARDIOMETABOLIC RISK;
   SMOKING-CESSATION; DIABETES-MELLITUS; SCHIZOPHRENIA; PEOPLE
AB Mental health programs need an instrument to monitor adherence to evidence-based physical health care for people with serious mental illness. The paper describes the Physical Health Care Fidelity Scale and study interrater reliability, frequency distribution, sensitivity to change and feasibility. Four fidelity assessments were conducted over 18 months at 13 sites randomized to implementation support for evidence-based physical health care. We found good to excellent interrater reliability, adequate sensitivity for change, good feasibility and wide variability in fidelity across sites after 18 months of implementation. Programs were more successful in establishing Policies stating physical health care standards than in implementing these Policies. The Physical Health Care Fidelity Scale measures and guides implementation of evidence-based physical health care reliably.
C1 [Ruud, Torleif; Heiervang, Kristin S.] Akershus Univ Hosp, Div Mental Hlth Serv, Lorenskog, Norway.
   [Ruud, Torleif] Univ Oslo, Inst Clin Med, Oslo, Norway.
   [Hoifodt, Tordis Sorensen; Hoye, Anne] Univ Hosp Northern Norway, Tromso, Norway.
   [Hoifodt, Tordis Sorensen; Hoye, Anne] UiT Arctic Univ Norway, Inst Clin Med, Tromso, Norway.
   [Hendrick, Delia Cimpean] WestBridge, Manchester, NH USA.
   [Drake, Robert E.; Bond, Gary R.] Westat Corp, Lebanon, NH USA.
   [Landers, Matthew] Duke Univ, Durham, NC USA.
C3 University of Oslo; University of Oslo; UiT The Arctic University of
   Tromso; University Hospital of North Norway; UiT The Arctic University
   of Tromso; Westat; Duke University
RP Ruud, T (corresponding author), Akershus Univ Hosp, Div Mental Hlth Serv, Lorenskog, Norway.; Ruud, T (corresponding author), Univ Oslo, Inst Clin Med, Oslo, Norway.
EM torleif.ruud@medisin.uio.no
RI Drake, Robert/AAS-3310-2020
OI Ruud, Torleif/0000-0002-4821-1267
FU South-Eastern Norway Regional Health Authority (Helse Sor-Ost HF)
   [2015106]
FX This study was funded by South-Eastern Norway Regional Health Authority
   (Helse Sor-Ost HF) (Grant No. 2015106).
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NR 45
TC 7
Z9 7
U1 1
U2 2
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0894-587X
EI 1573-3289
J9 ADM POLICY MENT HLTH
JI Adm. Policy. Ment. Health
PD NOV
PY 2020
VL 47
IS 6
SI SI
BP 901
EP 910
DI 10.1007/s10488-020-01019-0
EA FEB 2020
PG 10
WC Health Policy & Services; Public, Environmental & Occupational Health
WE Social Science Citation Index (SSCI)
SC Health Care Sciences & Services; Public, Environmental & Occupational
   Health
GA NY7NG
UT WOS:000515996100001
PM 32036479
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Tull, ES
   Cort, MA
   Yarandi, HN
AF Tull, Eugene S.
   Cort, Malcolm A.
   Yarandi, Hossein N.
TI The Association of Afro-Caribbean Immigrants' Feelings of Disconnection
   from the Community with the Metabolic Syndrome
SO JOURNAL OF IMMIGRANT AND MINORITY HEALTH
LA English
DT Article
DE Psychosocial stress; Afro-Caribbean; Metabolic syndrome; Insulin
   resistance; US Virgin Islands
ID INSULIN-RESISTANCE; UNITED-STATES; HEALTH; ACCULTURATION; STRESS;
   ETHNICITY; MORTALITY; AMERICAN; NATIVITY; GLUCOSE
AB Many immigrants can feel like outsiders in their adopted country. The objective of this study was to determine if psychosocial stress associated with feelings of disconnection from the community is associated with the metabolic syndrome (Met-S) among Afro-Caribbean immigrants. The frequency of the Met-S, based on International Diabetes Federation criteria, was determined for a population-based sample of 406 English-speaking Afro-Caribbean immigrants ages twenty and older in the Virgin Islands of the United States (USVI). Feelings of disconnection were assess with Roger's Life Attitude Inventory. Logistic regression analyses showed that a high level of disconnection was significantly associated with the Met-S [Odds Ratio = 1.64 (95 % CI 1.10-2.44)] after adjusting for conventional risk factors and for body mass index. Afro-Caribbean immigrants in the USVI who express a high level of disconnection from the community have an increased risk for the Met-S.
C1 [Tull, Eugene S.] Inter Amer Ctr Publ Hlth Improvement Inc, St Croix, VI 00823 USA.
   [Cort, Malcolm A.] Athens State Univ, Dept Behav Sci, Athens, AL 35611 USA.
   [Yarandi, Hossein N.] Wayne State Univ, Ctr Hlth Res, Detroit, MI 48202 USA.
C3 Athens State University; Wayne State University
RP Tull, ES (corresponding author), Inter Amer Ctr Publ Hlth Improvement Inc, POB 7863, St Croix, VI 00823 USA.
EM drmirt@yahoo.com
OI Tull, Eugene S./0000-0002-6825-0511
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NR 30
TC 0
Z9 1
U1 0
U2 2
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1557-1912
EI 1557-1920
J9 J IMMIGR MINOR HEALT
JI J. Immigr. Minor. Health
PD DEC
PY 2015
VL 17
IS 6
SI SI
BP 1848
EP 1853
DI 10.1007/s10903-014-0133-5
PG 6
WC Public, Environmental & Occupational Health
WE Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA CV0YS
UT WOS:000363980500031
PM 25398518
DA 2025-06-11
ER

PT J
AU Gonzalez-Paredes, FJ
   Mesa, GH
   Arraez, DM
   Reyes, RM
   Abrante, B
   Diaz-Flores, F
   Salido, E
   Quintero, E
   Hernández-Guerra, M
AF Javier Gonzalez-Paredes, Francisco
   Hernandez Mesa, Goretti
   Morales Arraez, Dalia
   Marcelino Reyes, Raquel
   Abrante, Beatriz
   Diaz-Flores, Felicitas
   Salido, Eduardo
   Quintero, Enrique
   Hernandez-Guerra, Manuel
TI Contribution of Cyclooxygenase End Products and Oxidative Stress to
   Intrahepatic Endothelial Dysfunction in Early Non-Alcoholic Fatty Liver
   Disease
SO PLOS ONE
LA English
DT Article
ID CIRRHOTIC RAT LIVERS; NITRIC-OXIDE; INSULIN-RESISTANCE;
   PORTAL-HYPERTENSION; THROMBOXANE A(2); CELL ACTIVATION; STEATOHEPATITIS;
   MICROCIRCULATION; PROSTANOIDS; ACID
AB Introduction
   Metabolic syndrome induces endothelial dysfunction, a surrogate marker of cardiovascular disease. In parallel, metabolic syndrome is frequently associated with non-alcoholic fatty liver disease (NAFLD), which may progress to cirrhosis. The aim of the present study was to evaluate intrahepatic endothelial dysfunction related to cyclooxygenase end products and oxidative stress as possible mechanisms involved in the pathophysiology of NAFLD.
   Materials and Methods
   Sprague-Dawley rats were fed standard diet (control-diet, CD) or high-fat-diet (HFD) for 6 weeks. Metabolic syndrome was assessed by recording arterial pressure, lipids, glycemia and rat body weight. Splanchnic hemodynamics were measured, and endothelial dysfunction was evaluated using concentration-effect curves to acetylcholine. Response was assessed with either vehicle, L-N-G-Nitroarginine (L-NNA), indomethacin, tempol, or a thromboxane receptor antagonist, SQ 29548. We quantified inflammation, fibrosis, oxidative stress, nitric oxide (NO) bioavailability and thromboxane B-2 levels.
   Results
   HFD rats exhibited metabolic syndrome together with the presence of NAFLD. Compared to control-diet livers, HFD livers showed increased hepatic vascular resistance unrelated to inflammation or fibrosis, but with decreased NO activity and increased oxidative stress. Endothelial dysfunction was observed in HFD livers compared with CD rats and improved after cyclooxygenase inhibition or tempol pre-incubation. However, pre-incubation with SQ 29548 did not modify acetylcholine response.
   Conclusions
   Our study provides evidence that endothelial dysfunction at an early stage of NAFLD is associated with reduced NO bioavailability together with increased cyclooxygenase end products and oxidative stress, which suggests that both pathways are involved in the pathophysiology and may be worth exploring as therapeutic targets to prevent progression of the disease.
C1 [Javier Gonzalez-Paredes, Francisco; Abrante, Beatriz; Salido, Eduardo; Quintero, Enrique; Hernandez-Guerra, Manuel] Univ La Laguna, Inst Biomed Technol, Tenerife, Spain.
   [Javier Gonzalez-Paredes, Francisco; Abrante, Beatriz; Salido, Eduardo; Quintero, Enrique; Hernandez-Guerra, Manuel] Univ La Laguna, Ctr Biomed Res Canary Isl CIBICAN, Tenerife, Spain.
   [Hernandez Mesa, Goretti; Morales Arraez, Dalia; Marcelino Reyes, Raquel; Quintero, Enrique; Hernandez-Guerra, Manuel] Univ Hosp Canary Isl, Dept Gastroenterol, Tenerife, Spain.
   [Diaz-Flores, Felicitas] Univ Hosp Canary Isl, Cent Lab, Tenerife, Spain.
   [Quintero, Enrique; Hernandez-Guerra, Manuel] Univ La Laguna, Dept Med & Psychiat, Tenerife, Spain.
C3 Universidad de la Laguna; Universidad de la Laguna; Universidad de la
   Laguna; University Hospital of the Canary Islands; Universidad de la
   Laguna; University Hospital of the Canary Islands; Universidad de la
   Laguna
RP Hernández-Guerra, M (corresponding author), Univ La Laguna, Inst Biomed Technol, Tenerife, Spain.; Hernández-Guerra, M (corresponding author), Univ La Laguna, Ctr Biomed Res Canary Isl CIBICAN, Tenerife, Spain.; Hernández-Guerra, M (corresponding author), Univ Hosp Canary Isl, Dept Gastroenterol, Tenerife, Spain.; Hernández-Guerra, M (corresponding author), Univ La Laguna, Dept Med & Psychiat, Tenerife, Spain.
EM mhernandezguerra@gmail.com
RI Hernandez-Guerra, Manuel/AFB-8988-2022; Salido, Eduardo/I-2232-2015;
   Quintero, Enrique/C-3841-2017
OI Hernandez-Guerra, Manuel/0000-0002-3478-9981; Salido,
   Eduardo/0000-0001-9599-9854; Quintero, Enrique/0000-0002-7244-8125
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NR 50
TC 37
Z9 37
U1 0
U2 7
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAY 26
PY 2016
VL 11
IS 5
AR e0156650
DI 10.1371/journal.pone.0156650
PG 15
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA DN2GQ
UT WOS:000376882500161
PM 27227672
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Marchesi, C
   Ebrahimian, T
   Angulo, O
   Paradis, P
   Schiffrin, EL
AF Marchesi, Chiara
   Ebrahimian, Talin
   Angulo, Orlando
   Paradis, Pierre
   Schiffrin, Ernesto L.
TI Endothelial Nitric Oxide Synthase Uncoupling and Perivascular Adipose
   Oxidative Stress and Inflammation Contribute to Vascular Dysfunction in
   a Rodent Model of Metabolic Syndrome
SO HYPERTENSION
LA English
DT Article
DE obesity; hypertension; NO; eNOS; superoxide; NADPH
ID ANGIOTENSIN-II; RESISTANCE ARTERIES; HYDROGEN-PEROXIDE; DEFICIENT MICE;
   HYPERTENSION; OVEREXPRESSION; ADIPONECTIN; MODULATION; STATEMENT;
   RECEPTOR
AB The metabolic syndrome represents a constellation of cardiovascular risk factors that promote the development of cardiovascular disease. Oxidative stress is a mediator of endothelial dysfunction and vascular remodeling. We investigated vascular dysfunction in the metabolic syndrome and the oxidant mechanisms involved. New Zealand obese (NZO) mice with metabolic syndrome and New Zealand black control mice were studied. NZO mice showed insulin resistance and increased visceral fat and blood pressure compared with New Zealand black mice. Mesenteric resistance arteries from NZO mice exhibited increased media: lumen ratio and media cross-sectional area, demonstrating hypertrophic vascular remodeling. Endothelium-dependent relaxation to acetylcholine, assessed by pressurized myography, was impaired in NZO mice, not affected by NG-nitro-L-arginine methyl ester, inhibitor of endothelial NO synthase, and improved by the antioxidant Tempol, suggesting reduced NO bioavailability and increased oxidative stress. Dimer: monomer ratio of endothelial NO synthase was decreased in NZO mice compared with New Zealand black mice, suggesting endothelial NO synthase uncoupling. Furthermore, vascular superoxide and peroxynitrite production was increased, as well as adhesion molecule expression. Perivascular adipose tissue of NZO mice showed increased superoxide production and NADPH oxidase activity, as well as adipocyte hypertrophy, associated with inflammatory Mac-3-positive cell infiltration. Vasoconstriction to norepinephrine decreased in the presence of perivascular adipose tissue in New Zealand black mice but was unaffected by perivascular adipose tissue in NZO mice, suggesting loss of perivascular adipose tissue anticontractile properties. Our data suggest that this rodent model of metabolic syndrome is associated with perivascular adipose inflammation and oxidative stress, hypertrophic resistance artery remodeling, and endothelial dysfunction, the latter a result of decreased NO and enhanced superoxide generated by uncoupled endothelial NO synthase. (Hypertension. 2009; 54: 1384-1392.)
C1 [Marchesi, Chiara; Ebrahimian, Talin; Angulo, Orlando; Paradis, Pierre; Schiffrin, Ernesto L.] McGill Univ, Sir Mortimer B Davis Jewish Gen Hosp, Lady Davis Inst Med Res, Montreal, PQ H3T 1E2, Canada.
   [Marchesi, Chiara] Univ Insubria, Dept Clin Med, Varese, Italy.
C3 McGill University; Jewish General Hospital - Montreal; Lady Davis
   Institute; University of Insubria
RP Schiffrin, EL (corresponding author), McGill Univ, Sir Mortimer B Davis Jewish Gen Hosp, Lady Davis Inst Med Res, B-127,3755 Cote Ste Catherine Rd, Montreal, PQ H3T 1E2, Canada.
EM ernesto.schiffrin@mcgill.ca
RI Schiffrin, Ernesto/AAB-9061-2019; Angulo, orlando/AAT-7195-2020
OI Schiffrin, Ernesto/0000-0002-4502-2823; Angulo,
   orlando/0000-0003-0920-3886
FU Merck-Frosst Canada; Canadian Institutes of Health Research [82790];
   Canada Research Chair on Hypertension and Vascular Research; Canada
   Research Chair Program of the Government of Canada; Canada Fund for
   Innovation; Heart and Stroke Foundation of Canada
FX The work of the authors was supported by a medical school grant from
   Merck-Frosst Canada, by the Canadian Institutes of Health Research grant
   82790, a Canada Research Chair on Hypertension and Vascular Research
   from the Canada Research Chair Program of the Government of Canada, and
   the Canada Fund for Innovation ( all to E. L. S.). T. E. received a
   fellowship from the Heart and Stroke Foundation of Canada.
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NR 34
TC 197
Z9 221
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0194-911X
EI 1524-4563
J9 HYPERTENSION
JI Hypertension
PD DEC
PY 2009
VL 54
IS 6
BP 1384
EP U149
DI 10.1161/HYPERTENSIONAHA.109.138305
PG 17
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 521TB
UT WOS:000271945900034
PM 19822799
OA Bronze
DA 2025-06-11
ER

PT J
AU Mitchell, AJ
   Malone, D
AF Mitchell, Alex J.
   Malone, Darren
TI Physical health and schizophrenia
SO CURRENT OPINION IN PSYCHIATRY
LA English
DT Article
DE atypical antipsychotics; cardiovascular disease; cerebrovascular
   disease; diabetes; hyperlipidaemia; medical comorbidity; metabolic
   syndrome; osteoporosis; physical illness; prevention; schizophrenia
ID SERIOUS MENTAL-ILLNESS; INDUCED WEIGHT-GAIN; 1966 BIRTH COHORT;
   ANTIPSYCHOTIC-DRUGS; ATYPICAL ANTIPSYCHOTICS; CARDIOVASCULAR-DISEASE;
   METABOLIC SYNDROME; DIABETES-MELLITUS; SERUM-LIPIDS; MEDICAL-CARE
AB Purpose of review: Patients with schizophrenia have higher than expected rates of morbidity and mortality. It is debatable whether this is related to shared risk factors, antipsychotic medication or inherent to the condition itself. This review will describe this association and the recent advances in the field.
   Recent findings: The majority of patients with schizophrenia have at least one chronic comorbid medical condition. In the absence of systematic screening this may or may not be brought to the attention of health professionals. The cause of high rates of physical illness appears to be multifactorial involving shared vulnerability and genetic factors. Yet it is vascular risk factors and the adverse effects of prescribed medication that are most amenable to intervention. Current atypical antipsychotics may offer neurological and cognitive benefits, but there is accumulating evidence of problems with weight gain, diabetes, lipid dysregulation; metabolic syndrome and sexual side effects.
   Summary: The physical health of patients with schizophrenia remains a concern. Yet the quality of medical and psychiatric care of patients with comorbid physical and mental health disorders has been shown to be unsatisfactory in several areas. We suggest that clinicians routinely assess and monitor physical health needs of patients with serious mental illness.
C1 Leicester Gen Hosp, Dept Liaison Psychiat, Brandon Unit, Leicester LE5 4PW, Leics, England.
C3 University Hospitals of Leicester NHS Trust; Leicester General Hospital
RP Mitchell, AJ (corresponding author), Leicester Gen Hosp, Dept Liaison Psychiat, Brandon Unit, Gwendolen Rd, Leicester LE5 4PW, Leics, England.
EM Alex.mitchell@leicspart.nhs.uk
RI Mitchell, Alex/A-3090-2009; Mitchell, Alex/P-5671-2015
OI Mitchell, Alex/0000-0001-6014-598X
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NR 57
TC 99
Z9 108
U1 0
U2 10
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0951-7367
EI 1473-6578
J9 CURR OPIN PSYCHIATR
JI Curr. Opin. Psychiatr.
PD JUL
PY 2006
VL 19
IS 4
BP 432
EP 437
PG 6
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 060KM
UT WOS:000238801100017
PM 16721177
DA 2025-06-11
ER

PT J
AU Stanciu, S
   Rusu, E
   Miricescu, D
   Radu, AC
   Axinia, B
   Vrabie, AM
   Ionescu, R
   Jinga, M
   Sirbu, CA
AF Stanciu, Silviu
   Rusu, Emilia
   Miricescu, Daniela
   Radu, Ana Cristina
   Axinia, Bianca
   Vrabie, Ana Maria
   Ionescu, Ruxandra
   Jinga, Mariana
   Sirbu, Carmen Adella
TI Links between Metabolic Syndrome and Hypertension: The Relationship with
   the Current Antidiabetic Drugs
SO METABOLITES
LA English
DT Review
DE hypertension; metabolic syndrome; type 2 diabetes mellitus; insulin
   resistance; metabolism; obesity; SGLT2-inhibitors; GLP-1 receptor
   agonist; tirzepatide; DPP-4 inhibitors
ID GLUCAGON-LIKE PEPTIDE-1; SYMPATHETIC-NERVOUS-SYSTEM; RECEPTOR AGONIST
   DULAGLUTIDE; AMBULATORY BLOOD-PRESSURE; TYPE-2 DIABETES-MELLITUS;
   HEART-RATE; CARDIOVASCULAR RISK; INSULIN-RESISTANCE; OXIDATIVE STRESS;
   ARTERIAL STIFFNESS
AB Hypertension poses a significant burden in the general population, being responsible for increasing cardiovascular morbidity and mortality, leading to adverse outcomes. Moreover, the association of hypertension with dyslipidaemia, obesity, and insulin resistance, also known as metabolic syndrome, further increases the overall cardiovascular risk of an individual. The complex pathophysiological overlap between the components of the metabolic syndrome may in part explain how novel antidiabetic drugs express pleiotropic effects. Taking into consideration that a significant proportion of patients do not achieve target blood pressure values or glucose levels, more efforts need to be undertaken to increase awareness among patients and physicians. Novel drugs, such as incretin-based therapies and renal glucose reuptake inhibitors, show promising results in decreasing cardiovascular events in patients with metabolic syndrome. The effects of sodium-glucose co-transporter-2 inhibitors are expressed at different levels, including renoprotection through glucosuria, natriuresis and decreased intraglomerular pressure, metabolic effects such as enhanced insulin sensitivity, cardiac protection through decreased myocardial oxidative stress and, to a lesser extent, decreased blood pressure values. These pleiotropic effects are also observed after treatment with glucagon-like peptide-1 receptor agonists, positively influencing the cardiovascular outcomes of patients with metabolic syndrome. The initial combination of the two classes may be the best choice in patients with type 2 diabetes mellitus and multiple cardiovascular risk factors because of their complementary mechanisms of action. In addition, the novel mineralocorticoid receptor antagonists show significant cardio-renal benefits, as well as anti-inflammatory and anti-fibrotic effects. Overall, the key to better control of hypertension in patients with metabolic syndrome is to consider targeting multiple pathogenic mechanisms, using a combination of the different therapeutic agents, as well as drastic lifestyle changes. This article will briefly summarize the association of hypertension with metabolic syndrome, as well as take into account the influence of antidiabetic drugs on blood pressure control.
C1 [Stanciu, Silviu; Jinga, Mariana] Carol Davila Univ Med & Pharm, Cent Mil Emergency Univ Hosp, Dept Internal Med & Gastroenterol, Bucharest 050474, Romania.
   [Rusu, Emilia] Carol Davila Univ Med & Pharm, Malaxa Clin Hosp, Dept Diabetol, Bucharest 02441, Romania.
   [Miricescu, Daniela] Carol Davila Univ Med & Pharm, Fac Dent Med, Dept Biochem, Bucharest 050474, Romania.
   [Radu, Ana Cristina] Malaxa Clin Hosp, Bucharest 02441, Romania.
   [Axinia, Bianca; Ionescu, Ruxandra] Cent Mil Emergency Univ Hosp, Dept Cardiol, Bucharest 050474, Romania.
   [Vrabie, Ana Maria] Carol Davila Univ Med & Pharm, Colentina Clin Hosp, Dept Cardiol, Bucharest 020125, Romania.
   [Sirbu, Carmen Adella] Cent Mil Emergency Univ Hosp, Dept Neurol, Bucharest 050474, Romania.
C3 Carol Davila University of Medicine & Pharmacy; Carol Davila University
   of Medicine & Pharmacy; Carol Davila University of Medicine & Pharmacy;
   Carol Davila University of Medicine & Pharmacy
RP Rusu, E (corresponding author), Carol Davila Univ Med & Pharm, Malaxa Clin Hosp, Dept Diabetol, Bucharest 02441, Romania.; Miricescu, D (corresponding author), Carol Davila Univ Med & Pharm, Fac Dent Med, Dept Biochem, Bucharest 050474, Romania.
EM emilia.rusu@umfcd.ro; daniela.miricescu@umfcd.ro
RI Daniela, Miricescu/G-8788-2016; Ionescu, Ruxandra
   Florentina/HOH-7976-2023; Vrabie, Ana-Maria/IWM-1867-2023; SIRBU, Carmen
   Adella/AAA-9317-2020; Jinga, Mariana/AAA-7101-2022; STANCIU,
   Silviu/HJY-0379-2023; Rusu, Emilia/AAU-1960-2021
OI Vrabie, Ana-Maria/0000-0002-8681-0607; Ana Cristina,
   Radu/0000-0001-9547-3780; Sirbu, Carmen Adella/0000-0002-1982-1066
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NR 154
TC 37
Z9 38
U1 1
U2 20
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2218-1989
J9 METABOLITES
JI Metabolites
PD JAN
PY 2023
VL 13
IS 1
AR 87
DI 10.3390/metabo13010087
PG 22
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 8G4RQ
UT WOS:000920333700001
PM 36677012
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Van Rheenen, TE
   McIntyre, RS
   Balanzá-Martínez, V
   Berk, M
   Rossell, SL
AF Van Rheenen, Tamsyn E.
   McIntyre, Roger S.
   Balanza-Martinez, Vicent
   Berk, Michael
   Rossell, Susan L.
TI Cumulative Cardiovascular Disease Risk and Triglycerides Differentially
   Relate to Subdomains of Executive Function in Bipolar Disorder;
   preliminary findings
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Metabolic syndrome; Obesity; Diet; BMI; Lipids; Framingham heart risk
   score; Cognition; Cognitive flexibility; Cognitive inhibition;
   Depression; Psychiatry; Mental health; Neuropsychology; Heart
ID BODY-MASS INDEX; CORONARY-HEART-DISEASE; COGNITIVE IMPAIRMENT; WAIST
   CIRCUMFERENCE; METABOLIC SYNDROME; NONFASTING TRIGLYCERIDES; OBESITY;
   HYPERTENSION; MORTALITY; IMPACT
AB Objectives: Cardiovascular disease is disproportionally prevalent in bipolar disorder (BD) and has been linked to cognition in preliminary studies. Herein we evaluate the association between known risk factors for cardiovascular disease and executive function in BD patients compared to healthy controls.
   Methods: In a sample of n=57 individuals (n=23 BD, n=34 controls) we assessed two subdomains of executive function; cognitive flexibility (using the Trail Making Test Part B) and cognitive inhibition (using the Stroop Colour Word Interference Task). Cardiovascular risk was assessed by means of serum triglyceride levels, body mass index (BMI) and waist circumference, as well as dietary saturated fat intake and a sex-specific cumulative cardiovascular risk score calculated using the Framingham Heart Study method.
   Results: Patients with BD had higher BMI and waist circumference, with more BD patients categorized as having central obesity than controls. In the BD group only, higher triglyceride levels were associated with worse cognitive flexibility, and elevated cumulative cardiovascular disease risk was associated with worse cognitive inhibition. No correlations between cardiovascular risk factors and executive function were evident in the control group.
   Limitations: The study was limited by the small sample size and should be considered hypothesis-generating
   Conclusions: The associations between triglyceride levels, cumulative cardiovascular disease risk and executive functioning evident in BD in this study preliminarily indicate the potential for mechanistic overlap of physical health and cognitive function in the disorder.
C1 [Van Rheenen, Tamsyn E.] Univ Melbourne, Melbourne Neuropsychiat Ctr, Dept Psychiat, Melbourne, Vic, Australia.
   [Van Rheenen, Tamsyn E.; Rossell, Susan L.] Swinburne Univ, Fac Hlth Arts & Design, Ctr Mental Hlth, Sch Hlth Sci, Melbourne, Vic, Australia.
   [Rossell, Susan L.] St Vincents Hosp, Dept Psychiat, Fitzroy, Vic, Australia.
   [Balanza-Martinez, Vicent] Univ Valencia, Dept Med, Teaching Unit Psychiat & Psychol Med, CIBERSAM, Valencia, Spain.
   [Balanza-Martinez, Vicent] Inst Salud Carlos III ISCIII, Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain.
   [Berk, Michael] Deakin Univ, Inst Mental & Phys Hlth & Clin Translat, Geelong, Vic, Australia.
   [Berk, Michael] Barwon Hlth, POB 281, Geelong, Vic 3220, Australia.
   [Berk, Michael] Univ Melbourne, Natl Ctr Excellence Youth Mental Hlth, Orygen, Parkville, Vic, Australia.
   [Berk, Michael] Univ Melbourne, Dept Psychiat, Parkville, Vic, Australia.
   [Berk, Michael] Univ Melbourne, Florey Inst Neurosci & Mental Hlth, Parkville, Vic, Australia.
   [McIntyre, Roger S.] Univ Toronto, Brain & Cognit Discovery Fdn, Mood Disorders Psychopharmacol Unit, Toronto, ON, Canada.
C3 University of Melbourne; Swinburne University of Technology; NSW Health;
   St Vincents Hospital Sydney; St Vincent's Health; St Vincent's Hospital
   Melbourne; CIBER - Centro de Investigacion Biomedica en Red; CIBERSAM;
   University of Valencia; CIBER - Centro de Investigacion Biomedica en
   Red; CIBERSAM; Deakin University; Barwon Health; Orygen, The National
   Centre of Excellence in Youth Mental Health; University of Melbourne;
   University of Melbourne; Florey Institute of Neuroscience & Mental
   Health; University of Melbourne; University of Toronto
RP Van Rheenen, TE (corresponding author), Melbourne Neuropsychiat Ctr, Level 3,Alan Gilbert Bldg,161 Barry St, Carlton, Vic 3053, Australia.
EM tamsyn.van@unimelb.edu.au
RI Balanzá-Martínez, Vicent/C-3073-2011; McIntyre, Roger/AAU-1000-2020;
   Berk, Michael/AGH-9427-2022; Berk, Michael/M-7891-2013
OI Balanza-Martinez, Vicent/0000-0001-7772-7396; Berk,
   Michael/0000-0002-5554-6946; Rossell, Susan/0000-0002-7415-8252
FU National Health and Medical Research Council (NHMRC) [1088785, 1154651,
   1059660, 1156072]; Instituto de Salud Carlos III [PI16/1770]; Helen
   McPherson Smith Trust; Australian Rotary Health/Bipolar Expedition
FX The National Health and Medical Research Council (NHMRC) provided salary
   support to TVR (Early Career Fellowship 1088785), SR (Senior Research
   Fellowship 1154651) and MB (Senior Principal Research Fellowships
   1059660 and 1156072). VBM acknowledges the support from Instituto de
   Salud Carlos III (PI16/1770, PROBILIFE study). The authors would also
   like to acknowledge the project specific financial support of the Helen
   McPherson Smith Trust and Australian Rotary Health/Bipolar Expedition.
   Finally, the authors would like to thank the participants in this study
   for their time and contribution
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NR 71
TC 12
Z9 11
U1 1
U2 5
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD JAN 1
PY 2021
VL 278
BP 556
EP 562
DI 10.1016/j.jad.2020.09.104
PG 7
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA PY8IX
UT WOS:000612286000019
PM 33022441
DA 2025-06-11
ER

PT J
AU Martino, G
   Caputo, A
   Vicario, CM
   Catalano, A
   Schwarz, P
   Quattropani, MC
AF Martino, Gabriella
   Caputo, Andrea
   Vicario, Carmelo M.
   Catalano, Antonino
   Schwarz, Peter
   Quattropani, Maria C.
TI The Relationship Between Alexithymia and Type 2 Diabetes: A Systematic
   Review
SO FRONTIERS IN PSYCHOLOGY
LA English
DT Review
DE alexithymia; psychological distress; type 2 diabetes mellitus; metabolic
   syndrome; chronic disease
ID QUALITY-OF-LIFE; GLYCEMIC CONTROL; METABOLIC SYNDROME; RISK-FACTOR;
   DEPRESSION; ANXIETY; HEALTH; ADHERENCE; MELLITUS; DISTRESS
AB Background:This systematic review analyzed the relationship between alexithymia, considered as the inability to recognize and express thoughts and emotions, and type 2 diabetes mellitus (T2DM), one of the most common chronic illness, characterized by a metabolic disorder burdened by high morbidity and mortality worldwide due to its outcomes. Methods:PRISMA guidelines were followed throughout this systematic review of the recent literature indexed in the databases PubMed, PsycInfo, Scopus, and Web of Science. Search terms for eligible studies were: "Type 2 diabetes" OR "T2DM" AND "Toronto Alexithymia Scale" OR "TAS-20"[All Fields]. Results:The initial search identified 61 indexed scientific publications. After screening we found that seven publications met the established scientific inclusion and exclusion criteria. It emerged that alexithymic patients ranged from 25 to 50% across the examined publications and it appeared that patients with T2DM generally reflected greater values of alexithymia, revealing particular differences among TAS domains. Moreover, emlpoyed participants were alexithymic to a greater extent compared to non-working participants (77.8 vs. 35.4%) and alexithymia was 2.63 times more severe among working participants when examining predictors of alexithymia. When evaluating the correlations between alexithymia and HbA1c or fasting blood glucose levels we found strong associations equal to 0.75 and 0.77 for TAS-20 total scores, respectively. While alexithymic participants showed significantly higher levels of HbA1c and blood glucose when compared to the non-alexithymic participants. Conclusions:The results of this systematic review of the current literature highlight the need of alexithymia evaluation in patients with T2DM. The high prevalence in T2DM and strong associations with poorly regulated diabetes and psychological distress, indicate a significant relationship between poor glycemic control and psychological distress, such as anxiety and depression, and quality of life. Further studies are needed focusing on age and gender differences in order to be able to improve clinical psychological care and prevention.
C1 [Martino, Gabriella; Catalano, Antonino; Quattropani, Maria C.] Univ Messina, Dept Clin & Expt Med, Messina, Italy.
   [Caputo, Andrea] Sapienza Univ Rome, Dept Dynam & Clin Psychol, Rome, Italy.
   [Vicario, Carmelo M.] Univ Messina, Dept Cognit Sci Psychol Educ & Cultural Studies, Messina, Italy.
   [Schwarz, Peter] Rigshosp, Copenhagen Univ Hosp, Dept Med Endocrinol, Copenhagen, Denmark.
C3 University of Messina; Sapienza University Rome; University of Messina;
   University of Copenhagen; Copenhagen University Hospital; Rigshospitalet
RP Martino, G (corresponding author), Univ Messina, Dept Clin & Expt Med, Messina, Italy.
EM martinog@unime.it
RI VICARIO, CARMELO/AAR-2521-2021; Schwarz, Peter/AAF-1558-2020; Caputo,
   Andrea/V-5276-2018; Catalano, Antonino/H-7109-2016; Quattropani,
   Maria/G-3504-2015; MARTINO, Gabriella/U-9158-2018
OI Quattropani, Maria C./0000-0003-0711-6412; MARTINO,
   Gabriella/0000-0001-9488-2021
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NR 87
TC 53
Z9 54
U1 3
U2 12
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-1078
J9 FRONT PSYCHOL
JI Front. Psychol.
PD AUG 28
PY 2020
VL 11
AR 2026
DI 10.3389/fpsyg.2020.02026
PG 10
WC Psychology, Multidisciplinary
WE Social Science Citation Index (SSCI)
SC Psychology
GA NQ0DJ
UT WOS:000570539100001
PM 32982843
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Angelico, F
   Loffredo, L
   Pignatelli, P
   Augelletti, T
   Carnevale, R
   Pacella, A
   Albanese, F
   Mancini, I
   Di Santo, S
   Del Ben, M
   Violi, F
AF Angelico, Francesco
   Loffredo, Lorenzo
   Pignatelli, Pasquale
   Augelletti, Teresa
   Carnevale, Roberto
   Pacella, Antonio
   Albanese, Fabiana
   Mancini, Ilaria
   Di Santo, Serena
   Del Ben, Maria
   Violi, Francesco
TI Weight loss is associated with improved endothelial dysfunction via
   NOX2-generated oxidative stress down-regulation in patients with the
   metabolic syndrome
SO INTERNAL AND EMERGENCY MEDICINE
LA English
DT Article
DE Metabolic syndrome; Oxidative stress; Diet; Endothelial dysfunction;
   Atherosclerosis
ID MEDIATED ARTERIAL DYSFUNCTION; LOW-CARBOHYDRATE DIET; MEDITERRANEAN
   DIET; NITRIC-OXIDE; BRACHIAL-ARTERY; FLOW; ADIPONECTIN; DILATATION;
   ADHERENCE; DISEASE
AB The aim of this study was to assess whether adherence to a restricted-calorie, Mediterranean-type diet improves endothelial dysfunction and markers of oxidative stress in patients with metabolic syndrome. A moderately low-calorie (600 calories/day negative energy balance), low-fat, high-carbohydrate diet (< 30% energy from fat, < 10% from saturated fat and 55% from carbohydrate) was prescribed to 53 outpatients with the metabolic syndrome. Participants were divided into two groups according to body weight loss > or < 5% after 6 months. Group A (n = 23) showed a remarkable decrease in body weight (-6.8%), body-mass-index (-4.6%), waist circumference (-4.8%), HOMA-IR (-27.2%), plasma glucose, glycosylated haemoglobin, total and LDL-cholesterol, blood pressure, serum NOX2 (the catalytic core of NADPH oxidase) (-22.2%) and urinary8-isoprostanes (-39.0%) and an increase of serum NOx (Nitrite/Nitrate) (+116.8%) and adiponectine (+125.5%) as compared with those in group B (n = 30). A statistically significant increase in brachial artery flow-mediated dilatation was observed in group A (+24.7%; p < 0.001), while no changes were present in group B. Variations of flow-mediated dilatation were statistically and negatively correlated with changes of serum NOX2 levels (p = 0.04), body-mass-index (p < 0.01), waist circumference (0.01), glycosylated haemoglobin (p < 0.01), LDL-cholesterol (p < 0.01) and triglycerides (p < 0.05) and positively correlated with changes of serum NOx (p < 0.001) and adiponectin (p = 0.01). The results show that moderate weight loss is able to improve endothelial dysfunction in patients with the metabolic syndrome. The coexistent decrease of NOX2 activation suggests a role for oxidative stress in eliciting artery dysfunction.
C1 [Angelico, Francesco; Loffredo, Lorenzo; Pignatelli, Pasquale; Augelletti, Teresa; Carnevale, Roberto; Pacella, Antonio; Albanese, Fabiana; Mancini, Ilaria; Di Santo, Serena; Del Ben, Maria; Violi, Francesco] Univ Roma La Sapienza, Med Clin 1, Dipartimento Med Interna & Specialita Med, Policlin Umberto I, I-00161 Rome, Italy.
C3 Sapienza University Rome; University Hospital Sapienza Rome
RP Angelico, F (corresponding author), Univ Roma La Sapienza, Med Clin 1, Dipartimento Med Interna & Specialita Med, Policlin Umberto I, Viale Policlin 155, I-00161 Rome, Italy.
EM francesco.angelico@uniroma1.it
RI Del Ben, Maria/AAE-7603-2020; Angelico, Francesco/AAB-6585-2020;
   pignatelli, pasquale/K-2116-2016; Violi, Francesco/K-1509-2016;
   Carnevale, Roberto/K-1472-2016; Loffredo, Lorenzo/K-4873-2016
OI pignatelli, pasquale/0000-0002-2265-7455; Violi,
   Francesco/0000-0002-6610-7068; Carnevale, Roberto/0000-0002-6216-9595;
   Loffredo, Lorenzo/0000-0002-6542-6235
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NR 39
TC 40
Z9 42
U1 0
U2 6
PU SPRINGER-VERLAG ITALIA SRL
PI MILAN
PA VIA DECEMBRIO, 28, MILAN, 20137, ITALY
SN 1828-0447
EI 1970-9366
J9 INTERN EMERG MED
JI Intern. Emerg. Med.
PD JUN
PY 2012
VL 7
IS 3
BP 219
EP 227
DI 10.1007/s11739-011-0591-x
PG 9
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 957AO
UT WOS:000305131100005
PM 21512794
DA 2025-06-11
ER

PT J
AU Lim, W
   So, WY
AF Lim, Wanki
   So, Wi-Young
TI Lifestyle-related factors and their association with metabolic syndrome
   in Korean adults: a population-based study
SO JOURNAL OF PHYSICAL THERAPY SCIENCE
LA English
DT Article
DE Korean; Lifestyle-related factors; Metabolic syndrome
ID RISK-FACTORS; CARDIOVASCULAR-DISEASE; WEIGHT-REDUCTION; INTERVENTION;
   MANAGEMENT; EXERCISE; PROGRAM; STRESS
AB [Purpose] The aim of this study was to investigate whether lifestyle-related factors are associated with metabolic syndrome (MetS) in community-dwelling Korean adults. [Subjects and Methods] The subjects comprised 590 men and 1,138 women aged 20 years and above. The subjects visited a public health promotion center in Seoul, Republic of Korea to participate in a survey regarding sleep duration, mental stress, educational level, economic status, and frequency of alcohol consumption and smoking. MetS was defined according to the standard definition of the National Cholesterol Education Program's Adult Treatment Panel III report. The relationship between lifestyle-related factors and MetS was assessed using multivariate logistic regression analysis after adjustments for age and sex. [Results] Sleep duration, educational level, economic status, and frequency of alcohol consumption and smoking were not associated with MetS. Mental stress was the only lifestyle-related factor associated with MetS. [Conclusion] Well-designed studies will be necessary in order to establish the lifestyle-related factors of MetS.
C1 [Lim, Wanki] Hoseo Univ, Dept Leisure Sports, Cheonan Si, South Korea.
   [So, Wi-Young] Korea Natl Univ Transportat, Coll Humanities & Arts, Sports & Hlth Care Major, Chungju Si 380702, Chungbuk, South Korea.
C3 Hoseo University; Korea National University of Transportation
RP So, WY (corresponding author), Korea Natl Univ Transportat, Coll Humanities & Arts, Sports & Hlth Care Major, 50 Daehak Ro, Chungju Si 380702, Chungbuk, South Korea.
EM wowso@ut.ac.kr
OI So, Wi-Young/0000-0002-9322-5852
FU Academic Research Program of Korea National University of Transportation
FX The research was supported by a grant from the Academic Research Program
   of Korea National University of Transportation in 2014.
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TC 8
Z9 8
U1 0
U2 3
PU SOC PHYSICAL THERAPY SCIENCE
PI TOKYO
PA C/O PUBLICATION CENTER, 1-24-12 SUGAMO, TOSHIMA-KU, TOKYO, 170-0002,
   JAPAN
SN 0915-5287
EI 2187-5626
J9 J PHYS THER SCI
JI J. Phys. Ther. Sci.
PD MAR
PY 2015
VL 27
IS 3
BP 555
EP 558
DI 10.1589/jpts.27.555
PG 4
WC Rehabilitation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Rehabilitation
GA CF3ZB
UT WOS:000352486600003
PM 25931679
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Costa-Santos, C
   Mattar, GGCD
   Fuziwara, RA
   Peres, JAD
   Queiroz, MS
AF Costa-Santos, Carolina
   Mattar, Gabriella Guarilha Costa Dias
   Fuziwara, Ronan Antonio
   Peres, Jorge Alexandre de Araujo
   Queiroz, Marcia Silva
TI Screen Time and Hours of Sleep Influence the Estimate Risk of Diabetes
   Mellitus and Metabolic Syndrome in Healthy Young Males
SO METABOLIC SYNDROME AND RELATED DISORDERS
LA English
DT Article
DE metabolic syndrome; diabetes mellitus; screen time; sleep time; risk
   factors
ID CONFIRMATORY FACTOR-ANALYSIS; ALL-CAUSE MORTALITY;
   CARDIOVASCULAR-DISEASE; SYSTOLIC HYPERTENSION; ADULTS; SEVERITY;
   DURATION; ASSOCIATION; PREVALENCE; GUIDELINES
AB Objective: Screen time (ST) has shown negative effects on physical and mental health, with an increase in the prevalence of overweight, metabolic syndrome (MetS), and obesity. The time spent in front of the screens was also associated with higher odds of selecting indicators of cardiometabolic disease in adulthood. In view of this, the aim of this study was to identify the risk of MetS and type 2 diabetes mellitus (T2DM) in healthy young males and relate it to ST and sleep time. Methods: We evaluated physical and laboratory characteristics, dichotomous diagnosis criteria, and continuous scores to assess MetS and Finnish Diabetes Risk Score questionnaire to measure the T2DM risk. Results: The means of MetS dichotomous and continuous severity criteria, among individuals with <7 hr of sleep, were higher than those with adequate sleep. We did not observe a direct impact of ST on the risk of MetS; nevertheless, >8 hr of ST increased 1.22 points in the T2DM risk. Conclusion: Excessive ST increased the risk of T2DM, but not of MetS. Moreover, sleeping <7 hr was associated with a higher mean of dichotomous and continuous severity criteria for MetS.
C1 [Costa-Santos, Carolina; Peres, Jorge Alexandre de Araujo; Queiroz, Marcia Silva] Univ Nove Julho UNINOVE, Programa Posgrad Med, Rua Vergueiro 235-249 Liberdade, BR-01504001 Sao Paulo, Brazil.
   [Costa-Santos, Carolina; Mattar, Gabriella Guarilha Costa Dias; Fuziwara, Ronan Antonio; Peres, Jorge Alexandre de Araujo] Hosp Forca Aerea Sao Paulo, Sao Paulo, Brazil.
C3 Universidade Nove de Julho
RP Queiroz, MS (corresponding author), Univ Nove Julho UNINOVE, Programa Posgrad Med, Rua Vergueiro 235-249 Liberdade, BR-01504001 Sao Paulo, Brazil.
EM marcia.queiroz@uni9.pro.br
RI Queiroz, Marcia/HDM-8486-2022; Queiroz, Marcia/L-9097-2015
OI Queiroz, Marcia/0000-0001-5113-6299
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NR 38
TC 1
Z9 1
U1 1
U2 5
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-4196
EI 1557-8518
J9 METAB SYNDR RELAT D
JI Metab. Syndr. Relat. Disord.
PD OCT 1
PY 2024
VL 22
IS 8
BP 626
EP 635
DI 10.1089/met.2024.0065
EA JUN 2024
PG 10
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA I1R4I
UT WOS:001241061800001
PM 38848280
DA 2025-06-11
ER

PT J
AU Brumby, S
   Chandrasekara, A
   McCoombe, S
   Kremer, P
   Lewandowski, P
AF Brumby, Susan
   Chandrasekara, Ananda
   McCoombe, Scott
   Kremer, Peter
   Lewandowski, Paul
TI Cardiovascular risk factors and psychological distress in Australian
   farming communities
SO AUSTRALIAN JOURNAL OF RURAL HEALTH
LA English
DT Article
DE obesity; mental health; farmer; cardiovascular disease
ID METABOLIC SYNDROME; LIFE-STYLE; OBESITY; DISEASE; OVERWEIGHT; FARMERS;
   BURDEN
AB Objective: To examine the prevalence of cardiovascular disease (CVD) risk factors, psychological distress and associations between physical and mental health parameters within a cohort of the Australian farming community. Design: Cross-sectional descriptive study. Setting: Farming communities across Australia. Participants: Data of men (n = 957) and women (n = 835) farmers from 97 locations across Australia were stratified into categories based on National Cholesterol Education Program guidelines. Main outcome measure(s): Prevalence of and interrelationship between overweight, obesity, dyslipidaemia, hypertension, diabetes risk and psychological distress. Results: There was a higher prevalence of overweight (42.5%, 95% confidence interval (CI), 34.250.8), obesity (21.8%, 95% CI, 18.325.3), abdominal adiposity (38.4% 95% CI, 24.552.5), hypertension (54.0%, 95% CI, 34.473.5) and diabetes risk (25.3%, 95% CI, 17.736.7) in the farming cohort compared with national data. There was also a positive significant association between the prevalence of psychological distress and obesity, abdominal adiposity, body fat percentage and metabolic syndrome in older (age = 50 years) participants. Conclusions: This study group of farming men and women exhibited an increased prevalence of CVD risk factors and co-morbidities. The findings indicate a positive association between psychological distress and risk for developing CVD, particularly in the older farmers. If the younger cohort were to maintain elevated rates of psychological distress, then it is foreseeable that the next generation of farmers could experience poorer physical health than their predecessors.
C1 [Brumby, Susan; Chandrasekara, Ananda; McCoombe, Scott] Natl Ctr Farmer Hlth, Western Dist Hlth Serv, Hamilton, Vic 3300, Australia.
   [Brumby, Susan; Chandrasekara, Ananda; McCoombe, Scott; Lewandowski, Paul] Deakin Univ, Sch Med, Geelong, Vic 3217, Australia.
   [Kremer, Peter] Deakin Univ, Sch Psychol, Geelong, Vic 3217, Australia.
C3 Deakin University; Deakin University
RP Brumby, S (corresponding author), Natl Ctr Farmer Hlth, Western Dist Hlth Serv, Hamilton, Vic 3300, Australia.
EM susan.brumby@wdhs.net
RI Chandrasekara, Ananda/AAV-4623-2021; Kremer, Peter/I-8202-2019
OI McCoombe, Scott/0000-0001-6717-7511; Kremer, Peter/0000-0003-2476-1958;
   Chandrasekara, Prof. Ananda/0000-0003-0947-6083; Brumby,
   Susan/0000-0001-6332-3374
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NR 25
TC 36
Z9 42
U1 1
U2 28
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1038-5282
EI 1440-1584
J9 AUST J RURAL HEALTH
JI Aust. J. Rural Health
PD JUN
PY 2012
VL 20
IS 3
BP 131
EP 137
DI 10.1111/j.1440-1584.2012.01273.x
PG 7
WC Public, Environmental & Occupational Health; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; Nursing
GA 946XH
UT WOS:000304390300007
PM 22620477
DA 2025-06-11
ER

PT J
AU Karamitsos, TD
   Arnold, JR
   Pegg, TJ
   Francis, JM
   Birks, J
   Jerosch-Herold, M
   Neubauer, S
   Selvanayagam, JB
AF Karamitsos, Theodoros D.
   Arnold, Jayanth R.
   Pegg, Tammy J.
   Francis, Jane M.
   Birks, Jacqueline
   Jerosch-Herold, Michael
   Neubauer, Stefan
   Selvanayagam, Joseph B.
TI Patients With Syndrome X Have Normal Transmural Myocardial Perfusion and
   Oxygenation A 3-T Cardiovascular Magnetic Resonance Imaging Study
SO CIRCULATION-CARDIOVASCULAR IMAGING
LA English
DT Article
DE ischemia; chest pain; microvascular angina; blood flow; oxygen
ID CARDIAC SYNDROME-X; NORMAL CORONARY ANGIOGRAMS; DOBUTAMINE STRESS
   ECHOCARDIOGRAPHY; POSITRON-EMISSION-TOMOGRAPHY; CHEST-PAIN;
   ARTERY-DISEASE; BLOOD-FLOW; ANGINA-PECTORIS; QUANTIFICATION; RESERVE
AB Background-The pathophysiology of chest pain in patients with cardiac syndrome X remains controversial. Advances in perfusion imaging with cardiovascular magnetic resonance (CMR) now enable absolute quantification of regional myocardial blood flow (MBF). Furthermore, blood oxygen level-dependent (BOLD) or oxygenation-sensitive CMR provides the unprecedented capability to assess regional myocardial oxygenation. We hypothesized that the combined assessment of regional perfusion and oxygenation with CMR could clarify whether patients with syndrome X show evidence of myocardial ischemia (reduced perfusion and oxygenation) during vasodilator stress compared with normal volunteers.
   Methods and Results-Eighteen patients with syndrome X (chest pain, abnormal exercise treadmill test, normal coronary angiogram without other causes of microvascular dysfunction) and 14 controls underwent CMR scanning at 3 T. Myocardial function, scar, perfusion (2-3 short-axis slices), and oxygenation were assessed. Absolute MBF was measured during adenosine stress (140 mu g/kg per minute) and at rest by model-independent deconvolution. For oxygenation, using a T2-prepared BOLD sequence, signal intensity was measured at adenosine stress and rest in the slice matched to the midventricular slice of the perfusion scan. There were no significant differences in MBF at stress (2.35 versus 2.37 mL/min per gram; P=0.91), BOLD signal change (17.3% versus 17.09%; P=0.91), and coronary flow reserve measurements (2.63 versus 2.53; P=0.60) in patients with syndrome X and controls, respectively. Oxygenation and perfusion measurements per coronary territory were also similar between the 2 groups. More patients with syndrome X (17/18 [94%]) developed chest pain during adenosine stress than controls (6/14 [43%]; P=0.004).
   Conclusions-Patients with syndrome X show greater sensitivity to chest pain compared with controls but no evidence of deoxygenation or hypoperfusion during vasodilatory stress. (Circ Cardiovasc Imaging. 2012;5:194-200.)
C1 [Karamitsos, Theodoros D.; Arnold, Jayanth R.; Pegg, Tammy J.; Francis, Jane M.; Neubauer, Stefan] Univ Oxford, Ctr Clin Magnet Resonance Res, Dept Cardiovasc Med, Oxford, England.
   [Birks, Jacqueline] Univ Oxford, Ctr Stat Med, Oxford, England.
   [Jerosch-Herold, Michael] Brigham & Womens Hosp, Dept Radiol, Boston, MA 02115 USA.
   [Selvanayagam, Joseph B.] Flinders Univ S Australia, Flinders Med Ctr, Dept Cardiovasc Med, Adelaide, SA 5001, Australia.
C3 University of Oxford; University of Oxford; Harvard University; Harvard
   University Medical Affiliates; Brigham & Women's Hospital; Flinders
   Medical Centre; Flinders University South Australia
RP Karamitsos, TD (corresponding author), John Radcliffe Hosp, Dept Cardiovasc Med, Headley Way, Oxford OX3 9DU, England.
EM theo.karamitsos@cardiov.ox.ac.uk
RI Karamitsos, Theodoros/AAF-8290-2021; Jerosch-Herold,
   Michael/R-9824-2019; Neubauer, Stefan/B-8448-2011
OI Selvanayagam, Joseph/0000-0003-4157-4265; Arnold,
   Jayanth/0000-0003-4533-8374; Karamitsos, Theodoros/0000-0002-4658-5273;
   Neubauer, Stefan/0000-0001-9017-5645
FU British Heart Foundation [PG/08/101/26126]; National Institute for
   Health Research Oxford Biomedical Research Centre; Oxford British Heart
   Foundation Centre for Research Excellence
FX This work was supported by a British Heart Foundation project grant
   (PG/08/101/26126). The authors also acknowledge support from the
   National Institute for Health Research Oxford Biomedical Research Centre
   Programme. Dr Neubauer acknowledges support from the Oxford British
   Heart Foundation Centre for Research Excellence.
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NR 37
TC 43
Z9 49
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1941-9651
EI 1942-0080
J9 CIRC-CARDIOVASC IMAG
JI Circ.-Cardiovasc. Imaging
PD MAR
PY 2012
VL 5
IS 2
BP 194
EP 200
DI 10.1161/CIRCIMAGING.111.969667
PG 7
WC Cardiac & Cardiovascular Systems; Radiology, Nuclear Medicine & Medical
   Imaging
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Radiology, Nuclear Medicine &
   Medical Imaging
GA 916SE
UT WOS:000302122700007
PM 22322441
DA 2025-06-11
ER

PT J
AU DeVallance, E
   Branyan, KW
   Lemaster, KC
   Anderson, R
   Marshall, KL
   Olfert, IM
   Smith, DM
   Kelley, EE
   Bryner, RW
   Frisbee, JC
   Chantler, PD
AF DeVallance, Evan
   Branyan, Kayla W.
   Lemaster, Kent C.
   Anderson, Ray
   Marshall, Kent L.
   Olfert, I. Mark
   Smith, David M.
   Kelley, Eric E.
   Bryner, Randy W.
   Frisbee, Jefferson C.
   Chantler, Paul D.
TI Exercise training prevents the perivascular adipose tissue-induced
   aortic dysfunction with metabolic syndrome
SO REDOX BIOLOGY
LA English
DT Article
DE Perivascular adipose tissue; Metabolic syndrome; Proteasome; Oxidative
   stress; Exercise
ID ENDOPLASMIC-RETICULUM STRESS; NITRIC-OXIDE SYNTHASE; ALL-CAUSE
   MORTALITY; OXIDATIVE STRESS; ENDOTHELIAL FUNCTION; PHENOTYPIC SWITCH;
   VASCULAR FUNCTION; BLOOD-PRESSURE; FEMALE RATS; TNF-ALPHA
AB The aim of the study was to determine the effects of exercise training on improving the thoracic perivascular adipose tissue (tPVAT) phenotype (inflammation, oxidative stress, and proteasome function) in metabolic syndrome and its subsequent actions on aortic function.
   Methods: Lean and obese (model of metabolic syndrome) Zucker rats (n=8/group) underwent 8-weeks of control conditions or treadmill exercise (70% of max speed, 1 h/day, 5 days/week). At the end of the intervention, the tPVAT was removed and conditioned media was made. The cleaned aorta was attached to a force transducer to assess endothelium-dependent and independent dilation in the presence or absence of tPVATconditioned media. tPVAT gene expression, inflammatory /oxidative phenotype, and proteasome function were assessed.
   Results: The main findings were that Ex induced: (1) a beige-like, anti-inflammatory tPVAT phenotype; (2) a greater abundance of (NO)-N-center dot in tPVAT; (3) a reduction in tPVAT oxidant production; and (4) an improved tPVAT proteasome function. Regarding aortic function, endothelium-dependent dilation was greater in exercised lean and obese groups vs. controls (p < 0.05). Lean control tPVAT improved aortic relaxation, whereas obese control tPVAT decreased aortic relaxation. In contrast, the obese Ex-tPVAT increased aortic dilation, whereas the lean Ex-tPVAT did not affect aortic dilation.
   Conclusion: Overall, exercise had the most dramatic impact on the obese tPVAT reflecting a change towards an environment with less oxidant load, less inflammation and improved proteasome function. Such beneficial changes to the tPVAT micro-environment with exercise likely played a significant role in mediating the improvement in aortic function in metabolic syndrome following 8 weeks of exercise.
C1 [DeVallance, Evan; Branyan, Kayla W.; Marshall, Kent L.; Olfert, I. Mark; Bryner, Randy W.; Chantler, Paul D.] WVU Sch Med, Div Exercise Physiol, Morgantown, WV USA.
   [Lemaster, Kent C.; Frisbee, Jefferson C.] Univ Western Ontario, Schulich Sch Med & Dent, Dept Physiol & Pharmacol, London, ON, Canada.
   [Anderson, Ray; Smith, David M.] WVU Sch Med, Dept Biochem, Morgantown, WV USA.
   [Kelley, Eric E.] WVU Sch Med, Dept Physiol & Pharmacol, Morgantown, WV USA.
   [Chantler, Paul D.] WVU Sch Med, Dept Neurosci, Morgantown, WV USA.
   [Frisbee, Jefferson C.] Univ Western Ontario, Schulich Sch Med & Dent, Dept Med Biophys, London, ON, Canada.
C3 West Virginia University; Western University (University of Western
   Ontario); West Virginia University; West Virginia University; West
   Virginia University; Western University (University of Western Ontario)
RP Chantler, PD (corresponding author), One Med Ctr Dr, Morgantown, WV 26505 USA.
EM pchantler@hsc.wvu.edu
RI Smith, David/AAL-7662-2020
OI Smith, David/0000-0002-1502-676X; Frisbee,
   Jefferson/0000-0003-2751-0599; Marshall, Kent/0000-0003-0105-8215
FU American Heart Association [IRG14330015]; AHA [14PRE20380386]; National
   Institute of General Medical Sciences of the National Institutes of
   Health [U54GM104942, 5P20GM109098]; American Heart Association (AHA)
   [14PRE20380386] Funding Source: American Heart Association (AHA)
FX This study was supported by the American Heart Association grants
   IRG14330015, pre-doctoral fellowship AHA (14PRE20380386); National
   Institute of General Medical Sciences of the National Institutes of
   Health (PDC and EEK; U54GM104942, and 5P20GM109098).
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NR 70
TC 27
Z9 29
U1 0
U2 1
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2213-2317
J9 REDOX BIOL
JI Redox Biol.
PD SEP
PY 2019
VL 26
AR 101285
DI 10.1016/j.redox.2019.101285
PG 12
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA JI9ZE
UT WOS:000493821500022
PM 31374361
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU van den Heuvel, LL
   du Plessis, S
   Stalder, T
   Acker, D
   Kirschbaum, C
   Carr, J
   Seedat, S
AF van den Heuvel, Leigh Luella
   du Plessis, Stefan
   Stalder, Tobias
   Acker, Debbie
   Kirschbaum, Clemens
   Carr, Jonathan
   Seedat, Soraya
TI Hair glucocorticoid levels in Parkinson's disease
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE Parkinson's disease; Hair cortisol levels; Hair cortisone levels;
   Metabolic syndrome; Stress
ID METABOLIC SYNDROME; CORTISOL; STRESS; DETERMINANTS; STIMULATION;
   VALIDATION; DIAGNOSIS; SCALE; ACTH
AB Background: Parkinson's disease (PD) and metabolic syndrome (MetS) share certain pathophysiological pathways, including hypothalamic pituitary adrenal (HPA) axis dysfunction. Hair glucocorticoid (GC) levels reflect longer-term HPA-axis function and can provide additional insights into the role of a dysregulated HPA-axis in PD and co-occurring cardiovascular disease (CVD) risk.
   Objectives: In a case-control study we examined the association of PD diagnosis, clinical features and PD-CVD risk (as defined by the MetS) co-occurrence with hair GC (cortisol and cortisone) levels.
   Methods: Hair samples, representing a three-month retrospective window of GC levels, were collected and analysed utilizing liquid chromatography tandem mass spectrometry in 56 females (25 PD patients and 31 controls) of mixed ancestry, aged between 45 and 78 years (PD patients, M = 64.5, SD = 8.4; controls, M = 55.7, SD = 6.9). Multivariate regression models were constructed with PD diagnostic status, clinical features and MetS comorbidity regressed on hair GC levels, adjusting for potential confounders.
   Results: The prevalence of MetS was 56.0 % in PD patients and 25.8 % in controls. Hair cortisone (adj B = 5.44, 95 % CI 2.05; 8.83, p = 0.002), but not hair cortisol levels (adj B = 0.05, 95 % CI -0.12; 0.22, p = 0.539), were significantly higher (Cohen's d = 0.87) in PD patients than in controls. Non-motor symptoms of PD (e.g., mood and anxiety) were significantly associated with hair cortisone levels (adj B = 0.29, 95 % CI 0.07; 0.51, p = 0.014). MetS was not associated with hair GC levels and there were no significant interactions between PD and MetS on hair GC levels.
   Conclusions: This study is the first study reporting on hair GC levels in PD. We found chronically increased cortisone, but not cortisol, levels in PD patients compared to controls. Furthermore, hair cortisone levels were significantly positively associated with PD symptoms related to mood, anhedonia, and anxiety. Hair GC levels were not associated with PD-MetS comorbidity in this sample. Hair cortisone levels may provide additional insights into HPA-axis dysfunction in PD.
C1 [van den Heuvel, Leigh Luella; du Plessis, Stefan; Acker, Debbie; Seedat, Soraya] Stellenbosch Univ, Fac Med & Hlth Sci, Dept Psychiat, Francie van Zijl Dr, ZA-7505 Cape Town, South Africa.
   [Stalder, Tobias] Univ Siegen, Clin Psychol, Adolf Reichwein Str 2, D-57076 Siegen, Germany.
   [Kirschbaum, Clemens] Tech Univ Dresden, Biol Psychol, Zellescher Weg 19, D-01062 Dresden, Germany.
   [Carr, Jonathan] Stellenbosch Univ, Fac Med & Hlth Sci, Dept Med, Francie van Zijl Dr, ZA-7505 Cape Town, South Africa.
C3 Stellenbosch University; Universitat Siegen; Technische Universitat
   Dresden; Stellenbosch University
RP van den Heuvel, LL (corresponding author), Stellenbosch Univ, Fac Med & Hlth Sci, Dept Psychiat, Clin Bldg,Room 5067 POB 241, ZA-8000 Cape Town, South Africa.
EM llvdh@sun.ac.za; stefandup@sun.ac.za;
   Tobias.Stalder@psychologie.uni-siegen.de; debbieacker69@gmail.com;
   clemens.kirschbaum@tu-dresden.de; jcarr@sun.ac.za; sseedat@sun.ac.za
RI du Plessis, Stefan/AFO-8572-2022; Carr, Jonathan/JSK-2055-2023; van den
   Heuvel, Leigh/AGV-5481-2022; Kirschbaum, Clemens/AAB-1752-2020
OI Stalder, Tobias/0000-0001-7558-1274; Seedat, Soraya/0000-0002-5118-786X;
   Carr, Jonathan/0000-0002-7677-426X; van den Heuvel,
   Leigh/0000-0003-3884-4754
FU South African Medical Research Council from the South African National
   Treasury under its Economic Competitiveness and Support Package
   [MRC-RFA-IFSP-01-2013/SHARED ROOTS]; South African Medical Research
   Council through its Division of Research Capacity Development under the
   SAMRC CLINICIAN RESEARCHER (M.D PHD) SCHOLARSHIP PROGRAMME from South
   African National Treasury; South African Research Chairs Initiative in
   PTSD - Department of Science and Technology; National Research
   Foundation; German Research Foundation [KI-537/37-1, STA 1213/6-1]
FX Research reported in this publication was supported by the South African
   Medical Research Council for the "Shared Roots" Flagship Project, Grant
   no. MRC-RFA-IFSP-01-2013/SHARED ROOTS" through funding received from the
   South African National Treasury under its Economic Competitiveness and
   Support Package. Its contents are solely the responsibility of the
   authors and do not necessarily represent the official views of the South
   African Medical Research Council. The work by Leigh van den Heuvel
   reported herein was made possible through funding by the South African
   Medical Research Council through its Division of Research Capacity
   Development under the SAMRC CLINICIAN RESEARCHER (M.D PHD) SCHOLARSHIP
   PROGRAMME from funding received from the South African National
   Treasury. The content hereof is the sole responsibility of the authors
   and do not necessarily represent the official views of the SAMRC or the
   funders. Soraya Seedat is supported by the South African Research Chairs
   Initiative in PTSD funded by the Department of Science and Technology
   and the National Research Foundation. The research reported in this
   publication was supported by the German Research Foundation, grants
   KI-537/37-1 and STA 1213/6-1
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NR 54
TC 17
Z9 17
U1 0
U2 10
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
EI 1873-3360
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD JUL
PY 2020
VL 117
AR 104704
DI 10.1016/j.psyneuen.2020.104704
PG 11
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA LY7SS
UT WOS:000540728600012
PM 32417621
DA 2025-06-11
ER

PT J
AU Nimrouzi, M
   Ruyvaran, M
   Zamani, A
   Nasiri, K
   Akbari, A
AF Nimrouzi, Majid
   Ruyvaran, Maede
   Zamani, Ali
   Nasiri, Khadijeh
   Akbari, Abolfazl
TI Oil and extract of safflower seed improve fructose induced metabolic
   syndrome through modulating the homeostasis of trace elements, TNF-α and
   fatty acids metabolism
SO JOURNAL OF ETHNOPHARMACOLOGY
LA English
DT Article
DE Safflower; Metabolic syndrome; Traces elements; TNF-alpha; Oxidative
   stress; Beta-oxidation
ID TINCTORIUS L. OIL; OXIDATIVE STRESS; MITOCHONDRIAL DYSFUNCTION;
   SEROTONIN DERIVATIVES; COPPER DEFICIENCY; PPAR-ALPHA; RATS; OBESITY;
   DIET; CHOLESTEROL
AB Ethnopharmacological relevance: Safflower (Carthamus tinctorius) has many applications in folk medicine. Its oil is used traditionally to treat obesity and other metabolic disorders. The anti-hypercholesterolemic and antioxidant effects of this plant have been well documented, but the anti-inflammatory effects and its role on fatty acid oxidation and homeostasis of trace elements are not fully understood.
   Objective: The aim of this study was to evaluate the protective effects of different doses of oil and extract of safflower seed against fructose induced metabolic syndrome by investigating the homeostasis of trace elements, TNF-alpha, and fatty acids metabolism.
   Methods: Eighty adult male Sprague-Dawley rats were randomly divided into ten groups and treated daily for 16 weeks. At the end of the study, plasma levels of liver enzymes, lipid profiles, blood glucose, insulin and TNF-alpha were measured. The levels of antioxidant enzymes and lipid peroxidation were also measured along with the expression of CD36, fatty acyl-CoA synthetase (FAS), and Carnitine palmitoyl transferase I (CPT-1) beta genes in the liver.
   Results: The antioxidant enzymes activity significantly decreased and lipid peroxidation, lipid profiles, liver enzymes, and TNF-alpha significantly increased in fructose-induced metabolic syndrome compared to the control groups, as well as the level of some trace elements significantly changed (p < 0.05). Treatment with oil and safflower seed extract in a dose dependent manner could improve biochemical parameters in groups of metabolic syndrome treated with oil and extract compared to metabolic syndrome (p < 0.05). The results also showed that the expression of above mentioned genes significantly increased in groups of metabolic syndrome treated with oil and extract compared to control and metabolic syndrome groups (p < 0.05).
   Conclusion: It can be concluded that safflower seed extract and its oil can improve fructose-induced metabolic syndrome through antioxidant and anti-inflammatory effects, adjustment of homeostasis of trace elements, and enhancing the beta-oxidation capacity of the liver by increasing the expression of CD36, FAS, and CPT-lbeta genes.
C1 [Nimrouzi, Majid; Ruyvaran, Maede] Shiraz Univ Med Sci, Sch Med, Dept Tradit Persian Med, Shiraz, Iran.
   [Ruyvaran, Maede] Shiraz Univ Med Sci, Student Res Comm, Shiraz, Iran.
   [Zamani, Ali] Shiraz Univ Med Sci, Endocrine & Metab Res Ctr, Dept Internal Med, Shiraz, Iran.
   [Nasiri, Khadijeh] Univ Mazandaran, Fac Sport Sci, Dept Exercise Physiol, Babol Sar, Iran.
   [Akbari, Abolfazl] Shiraz Univ, Sch Vet Med, Dept Physiol, Shiraz, Iran.
C3 Shiraz University of Medical Science; Shiraz University of Medical
   Science; Shiraz University of Medical Science; University of Mazandaran;
   Shiraz University
RP Akbari, A (corresponding author), POB 71345, Shiraz 71345, Iran.
EM Mnimruzi@yahoo.com; Mruyvaran@gmail.com; Zamania@sums.ac.ir;
   kh.nasiri@umz.ac.ir; Akbariabolfazl@gmail.com
RI Akbari, Abolfazl/R-9118-2017; Nasiri, Khadijeh/AAN-1545-2020; Zamani,
   Ali/P-6354-2018; Nimrouzi, Majid/L-6127-2013
OI Zamani, Ali/0000-0003-4135-2355; Nimrouzi, Majid/0000-0003-4630-2082
FU Shiraz University of Medical Sciences, Shiraz, Iran
FX This study was sponsored by Shiraz University of Medical Sciences,
   Shiraz, Iran. We acknowledge Dr. Maryam Ansari-Lari for her assistants
   in statistical analysis consulting.
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NR 67
TC 33
Z9 36
U1 1
U2 17
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0378-8741
EI 1872-7573
J9 J ETHNOPHARMACOL
JI J. Ethnopharmacol.
PD MAY 23
PY 2020
VL 254
AR 112721
DI 10.1016/j.jep.2020.112721
PG 12
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA KZ9SX
UT WOS:000523600200033
PM 32119951
DA 2025-06-11
ER

PT J
AU Vareldzis, R
   Perez, A
   Reisin, E
AF Vareldzis, Ramzi
   Perez, Annalisa
   Reisin, Efrain
TI Hyperuricemia: An Intriguing Connection to Metabolic Syndrome, Diabetes,
   Kidney Disease, and Hypertension
SO CURRENT HYPERTENSION REPORTS
LA English
DT Review
DE Hyperuricemia; Metabolic syndrome; Urate-lowering therapy; Hypertension;
   Chronic kidney disease
ID SERUM URIC-ACID; BLOOD-PRESSURE; ASYMPTOMATIC HYPERURICEMIA; ENDOTHELIAL
   DYSFUNCTION; CELL-PROLIFERATION; CIRCADIAN PATTERN; PATHOGENETIC ROLE;
   OXIDATIVE STRESS; RENAL-DISEASE; RISK-FACTORS
AB Purpose of the ReviewOur review explores the epidemiology, physiology, and clinical data surrounding the connection between hyperuricemia and metabolic syndrome, chronic kidney disease, and hypertension.Recent FindingsCompelling physiologic mechanisms have been proposed to explain a causal relationship between hyperuricemia and metabolic syndrome, chronic kidney disease, and hypertension but clinical studies have given mixed results in terms of whether intervening with hyperuricemia using urate-lowering therapy has any beneficial effects for patients with these conditions.SummaryDespite the large amount of research already put into this topic, more randomized placebo-controlled trials are needed to more firmly establish whether a cause-effect relationship exists and whether lowering uric acid levels in patients with these conditions is beneficial.
C1 [Vareldzis, Ramzi; Perez, Annalisa; Reisin, Efrain] Louisiana State Univ, Hlth Sci Ctr, Sect Nephrol & Hypertens, New Orleans, LA 70113 USA.
C3 Louisiana State University System; Louisiana State University Health
   Sciences Center New Orleans
RP Reisin, E (corresponding author), Louisiana State Univ, Hlth Sci Ctr, Sect Nephrol & Hypertens, New Orleans, LA 70113 USA.
EM ereisi@lsuhsc.edu
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NR 101
TC 24
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U2 105
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1522-6417
EI 1534-3111
J9 CURR HYPERTENS REP
JI Curr. Hypertens. Rep.
PD JUN
PY 2024
VL 26
IS 6
BP 237
EP 245
DI 10.1007/s11906-024-01295-3
EA JAN 2024
PG 9
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA TV2H1
UT WOS:001148087900001
PM 38270791
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Lappin, JM
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   Rosenbaum, S
   Dick, S
   Ward, P
   Curtis, J
AF Lappin, Julia Margaret
   Wijaya, Marlene
   Watkins, Andrew
   Morell, Rachel
   Teasdale, Scott
   Lederman, Oscar
   Rosenbaum, Simon
   Dick, Stephanie
   Ward, Philip
   Curtis, Jackie
TI Cardio-metabolic risk and its management in a cohort of
   clozapine-treated outpatients
SO SCHIZOPHRENIA RESEARCH
LA English
DT Article
DE Clozapine; Metabolic syndrome; Polypharmacy; Schizophrenia; Metabolic
   monitoring; Treatment
ID SERIOUS MENTAL-ILLNESS; DIABETES-MELLITUS; PHYSICAL-ACTIVITY;
   WEIGHT-GAIN; PSYCHOTIC DISORDERS; CATIE SCHIZOPHRENIA; BIPOLAR DISORDER;
   ASSESSMENT-TOOL; NHANES-III; MORTALITY
AB Objective: To comprehensively assess cardio-metabolic risk factors and their management in a large sample of outpatients treated with clozapine.
   Methods: Observational cross-sectional study of all clozapine users attending specialized clozapine monitoring outpatient clinics in three public hospitals in Sydney, Australia were approached to participate over the one-year period 01/10/2015-30/09/2016. Cardio-metabolic risk factors including metabolic syndrome, risk for future development of diabetes, smoking, physical activity, nutrition, and prescribed medications were assessed at face-to-face interview and through medical record review. Among patients who had cardio-metabolic risk factors, the proportion receiving appropriate management was assessed.
   Results: Of 451 registered clozapine clinic attenders, 92.2% completed questionnaires and anthropometric measurements. 58.3% met criteria for metabolic syndrome. 79.6% were overweight or obese. 55.9% had blood pressure meeting metabolic syndrome criteria. 46.6% had elevated fasting blood glucose and 55.2% had elevated blood triglycerides. 43.6% were current smokers. Only 10% achieved recommended weekly physical activity levels. Unhealthy food categories were highly consumed. 32.1% were on additional antipsychotics. In the majority of individuals, cardio-metabolic risk factors were untreated or under-treated.
   Conclusions: Clozapine use was associated with very high rates of cardiovascular and metabolic risk factors, which were frequently under-treated. Management of both physical and mental health should be prioritized. Polypharmacy should be rationalized. Future research should investigate the effectiveness of smoking cessation and lifestyle interventions in this high-risk population. (c) 2018 Elsevier B.V. All rights reserved.
C1 [Lappin, Julia Margaret; Wijaya, Marlene; Rosenbaum, Simon; Dick, Stephanie; Ward, Philip; Curtis, Jackie] Univ New South Wales, Sch Psychiat, Sydney, NSW 2052, Australia.
   [Watkins, Andrew; Morell, Rachel; Teasdale, Scott; Lederman, Oscar; Ward, Philip; Curtis, Jackie] South Eastern Sydney Local Hlth Dist, Keeping Body Mind Program, 15 Kingsway & Kareena Rd, Kogarah, NSW 2217, Australia.
   [Rosenbaum, Simon] Black Dog Inst, Hosp Rd, Sydney, NSW 2052, Australia.
C3 University of New South Wales Sydney; Black Dog Institute
RP Lappin, JM (corresponding author), Univ New South Wales, Sch Psychiat, Sydney, NSW 2052, Australia.
EM j.lappin@unsw.edu.au; m.wijaya@student.unsw.edu.au;
   Andrew.Watkins@health.nsw.gov.au; r.morell@unsw.edu.au;
   Scott.Teasdale@health.nsw.gov.au; Oscar.Lederman@health.nsw.gov.au;
   s.rosenbaum@unsw.edu.au; stephanie.dick@unsw.edu.au; p.ward@unsw.edu.au;
   Jackie.Curtis@health.nsw.gov.au
RI Lappin, Julia/AAA-6596-2020; Teasdale, Scott/AFP-0676-2022; Curtis,
   Jackie/J-5789-2019; Rosenbaum, Simon/Y-3241-2019; Ward,
   Philip/JCE-6293-2023
OI Lappin, Julia/0000-0001-5946-2144; Morell, Rachel/0000-0003-3065-5318;
   Lederman, Oscar/0000-0002-0321-5723; Curtis, Jackie/0000-0001-6884-0098;
   Teasdale, Scott/0000-0001-6769-8421; Watkins,
   Andrew/0000-0003-3452-8682; Rosenbaum, Simon/0000-0002-8984-4941; Ward,
   Philip/0000-0002-5779-7722
FU National Health and Medical Research Council (NHMRC) Early Career
   Fellowship [APP1123336]
FX SR was supported by a National Health and Medical Research Council
   (NHMRC) Early Career Fellowship (APP1123336). The funding sources did
   not partake in the design, data collection or analysis.
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NR 63
TC 31
Z9 32
U1 0
U2 9
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0920-9964
EI 1573-2509
J9 SCHIZOPHR RES
JI Schizophr. Res.
PD SEP
PY 2018
VL 199
BP 367
EP 373
DI 10.1016/j.schres.2018.02.035
PG 7
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA GT9FN
UT WOS:000444845900054
PM 29486959
DA 2025-06-11
ER

PT J
AU Büttner, M
   Jezova, D
   Greene, B
   Konrad, C
   Kircher, T
   Murck, H
AF Buettner, Matthias
   Jezova, Daniela
   Greene, Brandon
   Konrad, Carsten
   Kircher, Tilo
   Murck, Harald
TI Target-based biomarker selection - Mineralocorticoid receptor-related
   biomarkers and treatment outcome in major depression
SO JOURNAL OF PSYCHIATRIC RESEARCH
LA English
DT Article
DE Aldosterone; Cortisol; Mineralocorticoid receptor; Depressive disorder;
   Refractory depression; Therapy refractoriness; Salt appetite; Sodium;
   Magnesium; Systolic blood pressure; Heart rate variability; Slow wave
   sleep; Biomarker
ID STAR-ASTERISK-D; PREMENSTRUAL DYSPHORIC DISORDER; PITUITARY-ADRENAL
   AXIS; HEART-RATE-VARIABILITY; ANGIOTENSIN-ALDOSTERONE SYSTEM; FORCED
   SWIM TEST; METABOLIC SYNDROME; SODIUM APPETITE; STRESS RESPONSIVENESS;
   ATYPICAL DEPRESSION
AB Aldosterone and mineralocorticoid receptor (MR)-function have been related to depression. We examined central and peripheral parameters of MR-function in order to characterize their relationship to clinical treatment outcome after six weeks in patients with acute depression.
   30 patients with a diagnosis of major depression were examined 3 times over a 6 week period. Aldosterone and cortisol salvia samples were taken at 7.00 a.m. before patients got out of bed. Easy to use e-devices were used to measure markers of central MR function, i.e. slow wave sleep (SWS) and heart-rate variability (HRV). Salt-taste intensity (STI) and salt pleasantness (SP) of a 0.9% salt solution were determined by a newly developed scale. In addition, systolic blood pressure (SBP) and plasma electrolytes were determined as markers for peripheral MR activity. The relationship between the levels of these biomarkers at baseline and the change in clinical outcome parameters (Hamilton depression rating scale (HDRS)-21, anxiety, QIDS and BDI) after 6 weeks of treatment was investigated. A higher aldosterone/cortisol ratio (Aldo/Cort) (n = 17 due to missing values; p < 0.05) and lower SBP (n = 24; p <0.05) at baseline predicted poor outcome, as measured with the HDRS, independent of gender. Only in male patients higher STI, lower SP, lower SWS (all n = 13) and higher HRV (n = 11) at baseline predicted good outcome p <0.05). Likewise, in male patients low baseline sodium appears to be predictive for a poor outcome (n = 12; p = 0.05; based on HDRS-6). In conclusion, correlates of higher central MR-activation are associated with poorer clinical improvement, particularly in men. This contrasts with the finding of a peripheral MR-desensitization in more refractory patients. As one potential mechanism to consider, sodium loss on the basis of dysfunctional peripheral MR function and additional environmental factors may trigger increased aldosterone secretion and consequently worse outcome. These markers deserve further study as potential biological correlates for therapy refractory depression. (C) 2015 Elsevier Ltd. All rights reserved.
C1 [Buettner, Matthias; Konrad, Carsten; Kircher, Tilo; Murck, Harald] Univ Marburg, Clin Psychiat & Psychotherapy, Marburg, Germany.
   [Jezova, Daniela] Slovak Acad Sci, Inst Expt Endocrinol, Lab Pharmacol Neuroendocrinol, Bratislava, Slovakia.
   [Greene, Brandon] Univ Marburg, Inst Med Biometry & Epidemiol, Marburg, Germany.
   [Murck, Harald] Covance Inc, Princeton, NJ USA.
C3 Philipps University Marburg; Slovak Academy of Sciences; Institute of
   Experimental Endocrinology, SAS; Philipps University Marburg
RP Murck, H (corresponding author), Acorda Therapeut, 440 Saw Mill River Rd, Ardsley, NY 10502 USA.
EM mat.buettner@yahoo.de; ueenjezo@savba.sk;
   brandon.greene@staff.uni-marburg.de; Carsten.Konrad@uk-gm.de;
   kircher@med.uni-marburg.de; hmurck@acorda.com
RI Konrad, Carsten/JQV-4579-2023; Braunisch, Matthias/IUO-5344-2023; Murck,
   Harald/AAZ-1897-2020; Kircher, Tilo/AAT-6480-2020; Jezova,
   Daniela/F-3975-2018
OI Jezova, Daniela/0000-0003-1932-2950; Kircher, Tilo/0000-0002-2514-2625
FU VEGA [2/0057/15];  [APVV-0028-10]
FX The hormonal analyses were supported by a grant of APVV-0028-10 and VEGA
   2/0057/15. No additional external funding was involved.
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NR 121
TC 44
Z9 44
U1 0
U2 16
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-3956
EI 1879-1379
J9 J PSYCHIATR RES
JI J. Psychiatr. Res.
PD JUL-AUG
PY 2015
VL 66-67
BP 24
EP 37
DI 10.1016/j.jpsychires.2015.04.012
PG 14
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA CL2AT
UT WOS:000356746700004
PM 25959615
DA 2025-06-11
ER

PT J
AU Pan, Y
   Cai, WP
   Cheng, Q
   Dong, W
   An, T
   Yan, J
AF Pan, Yu
   Cai, Wenpeng
   Cheng, Qi
   Dong, Wei
   An, Ting
   Yan, Jin
TI Association between anxiety and hypertension: a systematic review and
   meta-analysis of epidemiological studies
SO NEUROPSYCHIATRIC DISEASE AND TREATMENT
LA English
DT Review
DE human; epidemiological association; anxiety disorder; hypertension;
   meta-analysis
ID AUTONOMIC NERVOUS-SYSTEM; BLOOD-PRESSURE; ENDOTHELIAL FUNCTION;
   GENERAL-POPULATION; METABOLIC SYNDROME; MENTAL-DISORDERS;
   ANGIOTENSIN-II; FOLLOW-UP; DEPRESSION; RISK
AB Background: Epidemiological studies have repeatedly investigated the association between anxiety and hypertension. However, the results have been inconsistent. This study aimed to summarize the current evidence from cross-sectional and prospective studies that evaluated this association.
   Methods: Seven common databases were searched for articles published up to November 2014. Cross-sectional and prospective studies that reported an association between the two conditions in adults were included. Data on prevalence, incidence, unadjusted or adjusted odds ratios or hazard ratios, and 95% confidence intervals (CIs) were extracted or calculated by the authors. The pooled odds ratio was calculated separately for cross-sectional and prospective studies using random-effects models. The Q test and I-2 statistic was used to assess heterogeneity. A funnel plot and modified Egger linear regression test were used to estimate publication bias.
   Results: The search yielded 13 cross-sectional studies (n=151,389), and the final pooled odds ratio was 1.18 (95% CI 1.02-1.37; P-Q<0.001; I-2=84.9%). Eight prospective studies with a total sample size of 80,146 and 2,394 hypertension case subjects, and the pooled adjusted hazard ratio was 1.55 (95% CI 1.24-1.94; P-Q<0.001; I-2=84.6%). The meta-regression showed that location, diagnostic criteria for anxiety, age, sex, sample size, year of publication, quality, and years of follow-up (for prospective study) were not sources of heterogeneity.
   Conclusion: Our results suggest that there is an association between anxiety and increased risk of hypertension. These results support early detection and management of anxiety in hypertensive patients.
C1 [Pan, Yu; Cai, Wenpeng; Dong, Wei; Yan, Jin] Second Mil Med Univ, Dept Psychol & Mental Hlth, Shanghai 200433, Peoples R China.
   [Pan, Yu] Peoples Liberat Army Gen Hosp, Dept Psychol, Beijing, Peoples R China.
   [Cheng, Qi] 102 Hosp PLA, Dept Child & Adolescent Behav Med, Changzhou, Peoples R China.
   [An, Ting] PLA Second Artillery Force Gen Hosp, Dept Internal Med, Beijing, Peoples R China.
C3 Naval Medical University; Chinese People's Liberation Army General
   Hospital
RP Yan, J (corresponding author), Second Mil Med Univ, Dept Psychol & Mental Hlth, 800 Xiangyin Rd, Shanghai 200433, Peoples R China.
EM yanjingk@qq.com
RI An, Ting/KLE-3659-2024; dong, wei/KVA-6898-2024
FU Psychological Subject of the General Logistics Department [12XLZ211];
   National Science and Technology Support Project [2009BAI77B04]; 
   [AWS13J003]
FX The study was supported by the army logistics scientific research funds
   (AWS13J003), the Psychological Subject of the General Logistics
   Department (12XLZ211), and the National Science and Technology Support
   Project (2009BAI77B04).
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NR 66
TC 161
Z9 188
U1 3
U2 30
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
EI 1178-2021
J9 NEUROPSYCH DIS TREAT
JI Neuropsychiatr. Dis. Treat.
PY 2015
VL 11
BP 1121
EP 1130
DI 10.2147/NDT.S77710
PG 10
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA CG4VA
UT WOS:000353284100002
PM 25960656
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Rosmond, R
   Björntorp, P
AF Rosmond, R
   Björntorp, P
TI Alterations in the hypothalamic-pituitary-adrenal axis in metabolic
   syndrome
SO ENDOCRINOLOGIST
LA English
DT Article
ID GLUCOCORTICOID-RECEPTOR GENE; BODY-FAT DISTRIBUTION;
   DEXAMETHASONE-SUPPRESSION TEST; CORTICOTROPIN-RELEASING HORMONE;
   SALIVARY CORTISOL; ABDOMINAL OBESITY; INSULIN-RESISTANCE;
   BLOOD-PRESSURE; LEPTIN LEVELS; SECRETION
AB Cortisol regulates adipose tissue differentiation, function, and distribution. In excess, cortisol causes visceral obesity. Visceral obesity is one of the key components of the metabolic syndrome. During the past decade, there has been an increasing interest in the role of stress in the pathogenesis of the metabolic syndrome, but in the absence of definitive data, the mechanisms have not been disclosed. With use of new methods for the assessment of cortisol, it has now been shown that inadequate cortisol secretion is associated with abnormalities in glucose, insulin, and lipid metabolism, including hypertension, bringing the importance of the hypothalamic-pituitary adrenal (HPA) axis in the control of human health to the forefront. In this overview, we briefly summarize the currently available information on physiological alterations in the HPA axis in the metabolic syndrome.
C1 Univ Gothenburg, Dept Internal Med, Res Ctr Endocrinol & Metab, Gothenburg, Sweden.
   Univ Gothenburg, Dept Heart & Lung Dis, Gothenburg, Sweden.
C3 University of Gothenburg; University of Gothenburg
RP Sahlgrens Univ Hosp, Dept Internal Med, Res Ctr Endocrinol & Metab, Grona Straket 8, S-41345 Gothenburg, Sweden.
EM roland.rosmond@medic.gu.se
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NR 59
TC 2
Z9 3
U1 0
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1051-2144
EI 1539-9192
J9 ENDOCRINOLOGIST
JI Endocrinologist
PD NOV-DEC
PY 2001
VL 11
IS 6
BP 491
EP 497
DI 10.1097/00019616-200111000-00010
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 501EC
UT WOS:000172669000009
DA 2025-06-11
ER

PT J
AU Amiri, P
   Deihim, T
   Nakhoda, K
   Hasheminia, M
   Montazeri, A
   Azizi, F
AF Amiri, Parisa
   Deihim, Tina
   Nakhoda, Kobra
   Hasheminia, Mita
   Montazeri, Ali
   Azizi, Fereidoun
TI Metabolic Syndrome and Health-related Quality of Life in Reproductive
   Age and Post-menopausal Women: Tehran Lipid and Glucose Study
SO ARCHIVES OF IRANIAN MEDICINE
LA English
DT Article
DE Menopause; metabolic syndrome; quality of life; women
ID RISK-FACTORS; POPULATION; MENOPAUSE; PREVALENCE; PROGRAM; SF-36; IRAN;
   MEN
AB Background: Given the lack of data clarifying the manner in which women with metabolic syndrome (MetS)sin different eras of their life perceive their health-related quality of life (HRQoL), this study aimed at investigating the association between MetS and HRQoL in reproductive age and post menopaLisal women.
   Methods: This was a cross-sectional study conducted within the framework of Tehran Lipid and Glucose Study (TLGS). Metabolic syndrome was defined according to the Joint Interim Statement (JIS) and HRQoL was assessed using the Short Form Health Survey (SF-36). Logistic regression analysis was used to estimate the odds ratio (OR) of poor HRQoL with 95% confidence intervals (CIs) for reproductive age and post-menopausal women separately and adjusted for confounding variables.
   Results: All 603 participants with (n = 340) and without (n = 263) MetS were studied. Overall, in both physical and mental domains, those without MetS had higher scores in all subscales of SF-36 except for vitality, role emotional and mental component summary. Unadjusted odds ratios (95% Cl) for poor physical HRQoL were 2.8 (1.7-4.6); (P < 0.001) and 1.5 (0.7-3.4) for the reproductive age and post-menopausal groups, respectively. Compared to the post-menopausal group, the odds ratio of reporting poor HRQoL for reproductive age women was significantly higher, even after adjusting for age (OR: 1.7, 95% CI: 1.0-3.0, P < 0.05).
   Conclusion: The results indicate that MetS is associated with poor HRQoL in reproductive age, but not in post-menopausal women, and the association is observed mainly in relation to physical rather than mental health.
C1 [Amiri, Parisa; Deihim, Tina; Hasheminia, Mita] Shahid Beheshti Univ Med Sci, Ctr Social Determinants Endocrine Hlth, Tehran, Iran.
   [Amiri, Parisa; Deihim, Tina; Hasheminia, Mita] Shahid Beheshti Univ Med Sci, Obes Res Ctr, Res Inst Endocrine Sci, Tehran, Iran.
   [Nakhoda, Kobra; Azizi, Fereidoun] Shahid Beheshti Univ Med Sci, Endocrine Res Ctr, Tehran, Iran.
   [Nakhoda, Kobra; Azizi, Fereidoun] Shahid Beheshti Univ Med Sci, Res Ctr Social Dept Endocrine Hlth, Res Inst Endocrine Sci, Tehran, Iran.
   [Montazeri, Ali] ACECR, Mental Hlth Res Grp, Hlth Metr Res Ctr, Iranian Inst Hlth Sci Res, Tehran, Iran.
C3 Shahid Beheshti University Medical Sciences; Shahid Beheshti University
   Medical Sciences; Shahid Beheshti University Medical Sciences; Shahid
   Beheshti University Medical Sciences; Academic Center for Education,
   Culture & Research (ACECR)
RP Azizi, F (corresponding author), Shahid Beheshti Univ Med Sci, Endocrine Res Ctr, Res Inst Endocrine Sci, POB 19395-4763, Tehran, Iran.
EM azizi@endocrine.ac.ir
RI Montazeri, Ali/C-9276-2009; Amiri, Parisa/K-1575-2017; Azizi,
   Fereidoun/ABD-4136-2021
OI Amiri, Parisa/0000-0002-6693-1057; Montazeri, Ali/0000-0002-5198-9539;
   Azizi, Fereidoun/0000-0002-6470-2517
FU Research Institute for Endocrine Sciences, Shahid Beheshti University of
   Medical Sciences, Tehran, Iran
FX This study is funded by the Research Institute for Endocrine Sciences,
   Shahid Beheshti University of Medical Sciences, Tehran, Iran. We express
   appreciation to the participants of the Tehran Lipid and Glucose Study
   and acknowledge Ms. Niloufar Shiva for critical editing of English
   grammar and syntax of the manuscript
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NR 37
TC 9
Z9 9
U1 0
U2 6
PU ACAD MEDICAL SCIENCES I R IRAN
PI TEHRAN
PA PO BOX 19395-5655, TEHRAN, 00000, IRAN
SN 1029-2977
EI 1735-3947
J9 ARCH IRAN MED
JI Arch. Iran. Med.
PD JUN
PY 2014
VL 17
IS 6
SI SI
BP 423
EP 428
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA AM3WF
UT WOS:000339782800007
PM 24916528
DA 2025-06-11
ER

PT J
AU Renna, N
   Risler, N
   Cruzado, M
   Gonzalez, S
   Lama, C
   Miatello, R
AF Renna, N
   Risler, N
   Cruzado, M
   Gonzalez, S
   Lama, C
   Miatello, R
TI Effect of nebivololon cardiovascular changes associated with a rat model
   of insulin-resistance
SO CELLULAR AND MOLECULAR BIOLOGY
LA English
DT Article
DE nebivolol; hypertension; insulin-resistance syndrome; vascular
   remodeling; fructose-fed rats
ID NITRIC-OXIDE SYNTHASE; FRUCTOSE-FED RATS; ENDOTHELIAL DYSFUNCTION;
   OXIDATIVE INACTIVATION; HYPERTENSIVE-RATS; DIABETIC RATS; INCREASES;
   ENALAPRIL; DISEASE; STRESS
AB Nebivolol is a vasodilator that combines beta-adrenergic blocking activity with a relaxant effect on vascular smooth muscle cells (VSMC) mediated by the endothelial nitric oxide ( NO) pathway. FFR provide a model of dietary-induced insulin-resistance syndrome, which has been used to study the pathophysiological mechanisms associated with this syndrome. Our main objective was to examine the effect of long-term administration of nebivolol on metabolic and cardiovascular variables in fructose-fed rats ( FFR), a model in which an altered bioavailability of NO has been already described. Male Wistar rats were randomly assigned to 4 groups (n = 8 each): I. Control (C); II. Control + nebivolol (C+N): 1 mg/kg(-1). day(-1) in drinking water during the last 4 weeks. III. FFR: rats receiving fructose in drinking water as a 10% (w/v) solution during 8 weeks, and IV. FFR+N: idem II plus III. During the 8 weeks experimental period, variations in systolic blood pressure (SBP), glucose tolerance test (GTT) and plasma thiobarbituric acid-reactive substances (TBARS) were assessed. At the end of this experimental period, rats were killed and heart and kidneys were excised for calculation of relative heart weight (RHW) and histological evaluation of lumen to media ratio (L/M) in renal arteries. Rats from FFR group increased their SBP and RHW, showed glucose intolerance and an increment in lipid peroxidation. Moreover, FFR showed vascular remodeling in renal arteries evidenced by changes in L/M. Although the metabolic changes were not reverted by the administration of nebivolol, this drug successfully decreased SBP, TBARS levels and reverted structural changes such as cardiac hypertrophy and renal arterial remodeling. Data demonstrate that nebivolol administration could participate in the reversion of cardiovascular structural changes associated with the insulin-resistance syndrome.
C1 Univ Nacl Cuyo, Sch Med, Dept Morphophysiol, RA-5500 Mendoza, Argentina.
   Univ Nacl Cuyo, Sch Med, Dept Pathol, RA-5500 Mendoza, Argentina.
   Consejo Nacl Invest Cient & Tecn, IMBECU, Mendoza, Argentina.
C3 University Nacional Cuyo Mendoza; University Nacional Cuyo Mendoza;
   Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET);
   Instituto de Medicina y BiologIa Experimental de Cuyo (IMBECU)
RP Univ Nacl Cuyo, Sch Med, Dept Morphophysiol, RA-5500 Mendoza, Argentina.
EM rmiatell@fcm.uncu.edu.ar
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NR 31
TC 11
Z9 12
U1 0
U2 0
PU C M B  ASSOC
PI POITIERS
PA 34 BOULEVARD SOLFERINO, 86000 POITIERS, FRANCE
SN 0145-5680
EI 1165-158X
J9 CELL MOL BIOL
JI Cell. Mol. Biol.
PY 2005
VL 51
IS 6
BP 531
EP 537
DI 10.1170/T660
PG 7
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA 034OL
UT WOS:000236939000003
PM 16309577
DA 2025-06-11
ER

PT J
AU Light, LEO
   Bartlett, TQ
   Poyas, A
   Nijland, MJ
   Huber, HF
   Li, C
   Keenan, K
   Nathanielsz, PW
AF Light, Lydia E. O.
   Bartlett, Thad Q.
   Poyas, Annica
   Nijland, Mark J.
   Huber, Hillary F.
   Li, Cun
   Keenan, Kate
   Nathanielsz, Peter W.
TI Maternal activity, anxiety, and protectiveness during moderate nutrient
   restriction in captive baboons (Papio sp.)
SO JOURNAL OF MEDICAL PRIMATOLOGY
LA English
DT Article
DE developmental programming; mother-infant interactions; nutrition
ID MACAQUES MACACA-MULATTA; RANGING RHESUS-MONKEYS; FETAL BABOON; CALORIC
   RESTRICTION; NUTRITIONAL MANIPULATION; DEVELOPMENTAL ORIGINS;
   GLUCOCORTICOID LEVELS; METABOLIC SYNDROME; STRESS RESPONSES; FOOD
   RESTRICTION
AB BackgroundWe hypothesized that maternal nutrient restriction (NR) would increase activity and behavioral indicators of anxiety (self-directed behaviors, SDBs) in captive baboons (Papio sp.) and result in more protective maternal styles.
   MethodsOur study included 19 adult female baboons. Seven females ate ad libitum (control group), and eight females ate 30% less (NR group) and were observed through pregnancy and lactation.
   ResultsControl females engage in higher rates of SDB than NR females overall (P.018) and during the prenatal period (P.001) and engage in more aggressive behavior (P.033). Control females retrieved infants more than NR females during weeks 5-8 postpartum (P.019).
   ConclusionsLower SDB rates among prenatal NR females reduce energy expenditure and increase available resources for fetal development when nutritionally restricted. Higher infant retrieval rates by controls may indicate more infant independence rather than maternal style differences.
C1 [Light, Lydia E. O.] Univ North Carolina Charlotte, Dept Anthropol, Charlotte, NC 28223 USA.
   [Light, Lydia E. O.; Bartlett, Thad Q.; Poyas, Annica] Univ Texas San Antonio, Dept Anthropol, San Antonio, TX USA.
   [Nijland, Mark J.] Univ Texas Hlth Sci Ctr San Antonio, Dept Obstet & Gynecol, San Antonio, TX 78229 USA.
   [Huber, Hillary F.; Li, Cun; Nathanielsz, Peter W.] Univ Wyoming, Dept Anim Sci, Laramie, WY 82071 USA.
   [Keenan, Kate] Univ Chicago, Dept Psychiat, Chicago, IL 60637 USA.
   [Nathanielsz, Peter W.] Southwest Natl Primate Res Ctr, San Antonio, TX USA.
C3 University of North Carolina; University of North Carolina Charlotte;
   University of Texas System; University of Texas at San Antonio (UTSA);
   University of Texas System; University of Texas Health Science Center at
   San Antonio; University of Wyoming; University of Chicago; Texas
   Biomedical Research Institute
RP Light, LEO (corresponding author), Univ North Carolina Charlotte, Dept Anthropol, Charlotte, NC 28223 USA.
EM llight1@uncc.edu
RI Light, Lydia/ABF-4036-2020
OI Keenan, Kathryn/0000-0002-1775-8171; Nijland, Mark/0000-0003-0998-8804;
   Bartlett, Thad/0000-0001-5994-9454; Nathanielsz,
   Peter/0000-0001-8410-6280; Light, Lydia/0000-0001-9791-3487
FU Foundation for the National Institutes of Health [5R24 RR021367, R21
   HD057480]; San Antonio Life Sciences Institute
FX Foundation for the National Institutes of Health, Grant/Award Number:
   5R24 RR021367 and R21 HD057480; San Antonio Life Sciences Institute
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NR 78
TC 2
Z9 2
U1 0
U2 11
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0047-2565
EI 1600-0684
J9 J MED PRIMATOL
JI J. Med. Primatol.
PD AUG
PY 2018
VL 47
IS 4
BP 247
EP 256
DI 10.1111/jmp.12350
PG 10
WC Veterinary Sciences; Zoology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Veterinary Sciences; Zoology
GA GN9IS
UT WOS:000439510000006
PM 29749628
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Tain, YL
   Hsu, CN
AF Tain, You-Lin
   Hsu, Chien-Ning
TI Nutritional Approaches Targeting Gut Microbiota in
   Oxidative-Stress-Associated Metabolic Syndrome: Focus on Early Life
   Programming
SO NUTRIENTS
LA English
DT Review
DE hypertension; metabolic syndrome; developmental origins of health and
   disease (DOHaD); oxidative stress; gut microbiota; short-chain fatty
   acid; probiotics; nitric oxide
ID HIGH-FAT DIET; IN-UTERO EXPOSURE; ARYL-HYDROCARBON RECEPTOR;
   RENIN-ANGIOTENSIN SYSTEM; REDUCES NEPHRON NUMBER; LOW-BIRTH-WEIGHT;
   BLOOD-PRESSURE; SUPPLEMENTATION PREVENTS; DEVELOPMENTAL ORIGINS;
   PLASMA-CONCENTRATIONS
AB Metabolic syndrome (MetS) denotes a constellation of risk factors associated with the development of cardiovascular disease, with its roots potentially traced back to early life. Given the pivotal role of oxidative stress and dysbiotic gut microbiota in MetS pathogenesis, comprehending their influence on MetS programming is crucial. Targeting these mechanisms during the early stages of life presents a promising avenue for preventing MetS later in life. This article begins by examining detrimental insults during early life that impact fetal programming, ultimately contributing to MetS in adulthood. Following that, we explore the role of oxidative stress and the dysregulation of gut microbiota in the initiation of MetS programming. The review also consolidates existing evidence on how gut-microbiota-targeted interventions can thwart oxidative-stress-associated MetS programming, encompassing approaches such as probiotics, prebiotics, postbiotics, and the modulation of bacterial metabolites. While animal studies demonstrate the favorable effects of gut-microbiota-targeted therapy in mitigating MetS programming, further clinical investigations are imperative to enhance our understanding of manipulating gut microbiota and oxidative stress for the prevention of MetS.
C1 [Tain, You-Lin] Kaohsiung Chang Gung Mem Hosp, Div Pediat Nephrol, Kaohsiung 833, Taiwan.
   [Tain, You-Lin] Kaohsiung Chang Gung Mem Hosp, Inst Translat Res Biomed, Kaohsiung 833, Taiwan.
   [Tain, You-Lin] Chang Gung Univ, Coll Med, Taoyuan 333, Taiwan.
   [Hsu, Chien-Ning] Kaohsiung Chang Gung Mem Hosp, Dept Pharm, Kaohsiung 833, Taiwan.
   [Hsu, Chien-Ning] Kaohsiung Med Univ, Sch Pharm, Kaohsiung 807, Taiwan.
C3 Chang Gung Memorial Hospital; Chang Gung Memorial Hospital; Chang Gung
   University; Chang Gung Memorial Hospital; Kaohsiung Medical University
RP Hsu, CN (corresponding author), Kaohsiung Chang Gung Mem Hosp, Dept Pharm, Kaohsiung 833, Taiwan.; Hsu, CN (corresponding author), Kaohsiung Med Univ, Sch Pharm, Kaohsiung 807, Taiwan.
EM tainyl@cgmh.org.tw; cnhsu@cgmh.org.tw
RI Hsu, Chien-Ning/GLS-4014-2022; Tain, You-Lin/H-2827-2019
OI Tain, You-Lin/0000-0002-7059-6407; Hsu, Chien-Ning/0000-0001-7470-528X
FU Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan
FX No Statement Available
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NR 207
TC 3
Z9 3
U1 0
U2 0
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD MAR
PY 2024
VL 16
IS 5
AR 683
DI 10.3390/nu16050683
PG 22
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA KW2A3
UT WOS:001182921800001
PM 38474810
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Olofinnade, AT
   Onaolapo, AY
   Onaolapo, OJ
   Olowe, OA
   Mollica, A
   Zengin, G
   Stefanucci, A
AF Olofinnade, Anthony T.
   Onaolapo, Adejoke Y.
   Onaolapo, Olakunle J.
   Olowe, Olugenga A.
   Mollica, Adriano
   Zengin, Gokhan
   Stefanucci, Azurra
TI Corylus avellana L. modulates neurobehaviour and brain
   chemistry following high-fat diet
SO FRONTIERS IN BIOSCIENCE-LANDMARK
LA English
DT Article
DE Antioxidant; Brain; Corylus avellana; Functional food; Nutraceutical;
   Neurobehaviour; Metabolic
ID OXIDATIVE STRESS; LIPID PROFILE; HAZELNUT; ANXIETY; OBESITY; MEMORY;
   LEVEL; RATIO; MICE
AB Consumption of a high-fat diet has adverse impacts on metabolism, neurobehavioral, and neurochemical homeostasis in both humans and experimental animals. Here, we examined the effects of two different cultivars of Corylus avellana L. in a mouse model of metabolic syndrome. Corylus avellana L. reduced weight gain in mice that were treated with a high-fat diet, improved their behavioral parameters as exemplified by locomotion and rearing, working-memory, and reduced grooming and anxiety indices. Both Corylus avellana L. varieties reduced blood glucose levels and lipid peroxidation, improved lipid profile, and antioxidant status in mice placed on a high fat diet. Finally, brain acetylcholinesterase activity was also reduced, dopamine level was increased, while caspase-3 level was reduced. Thus, the Corylus avellana L. cultivars improve metabolic, behavioral, and neurochemical homeostasis in a diet with a high-fat content.
C1 [Olofinnade, Anthony T.] Lagos State Univ, Coll Med, Fac Basic Clin Sci, Dept Pharmacol Therapeut & Toxicol, Ikeja, Lagos State, Nigeria.
   [Onaolapo, Adejoke Y.] Ladoke Akintola Univ Technol, Dept Anat, Behav Neurosci Neurobiol Unit, Ogbomosho, Oyo State, Nigeria.
   [Olofinnade, Anthony T.; Onaolapo, Olakunle J.] Ladoke Akintola Univ Technol, Dept Pharmacol, Behav Neurosci Neuropharmacol Unit, Osogbo, Osun State, Nigeria.
   [Olowe, Olugenga A.] Ladoke Akintola Univ Technol, Dept Med Microbiol & Parasitol, Osogbo, Osun State, Nigeria.
   [Mollica, Adriano; Stefanucci, Azurra] Univ G dAnnunzio, Dept Pharm, Via Vestini 31, I-66100 Chieti, Italy.
   [Zengin, Gokhan] Selcuk Univ, Sci Fac, Dept Biol, Konya, Turkey.
C3 Lagos State University; G d'Annunzio University of Chieti-Pescara;
   Selcuk University
RP Onaolapo, OJ (corresponding author), Ladoke Akintola Univ Technol, Dept Pharmacol, Behav Neurosci Neuropharmacol Unit, Osogbo, Osun State, Nigeria.
EM olakunleonaolapo@yahoo.co.uk
RI Zengin, Gokhan/GLS-8806-2022; Mollica, Adriano/K-2747-2016; Onaolapo,
   Adejoke/HRC-4273-2023; Zengin, Gokhan/K-9393-2015
OI Zengin, Gokhan/0000-0001-6548-7823; Stefanucci,
   Azzurra/0000-0001-7525-2913
CR Amri Z, 2017, BMC COMPLEM ALTERN M, V17, DOI 10.1186/s12906-017-1842-9
   Lima RPA, 2017, CLIN EPIGENETICS, V9, DOI 10.1186/s13148-017-0407-6
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   Onaolapo Olakunle James, 2016, Pathophysiology, V23, P147, DOI 10.1016/j.pathophys.2016.05.001
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   Tiamiyu AO, 2019, CURR AGING SCI PRESS
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NR 29
TC 13
Z9 15
U1 3
U2 12
PU IMR PRESS
PI ROBINSON
PA 112 ROBINSON RD, ROBINSON, SINGAPORE
SN 2768-6701
EI 2768-6698
J9 FRONT BIOSCI-LANDMRK
JI Front. Biosci.
PD JAN 1
PY 2021
VL 26
IS 3
BP 537
EP 551
DI 10.2741/4906
PG 15
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA RP0HV
UT WOS:000641419000008
PM 33049682
OA hybrid
DA 2025-06-11
ER

PT J
AU Rakowski-Anderson, T
   Wong, HL
   Rothermel, B
   Cain, P
   Lavilla, C
   Pullium, JK
   Hoeffer, C
AF Rakowski-Anderson, Tammy
   Wong, Helen
   Rothermel, Beverly
   Cain, Peter
   Lavilla, Carmencita
   Pullium, Jennifer K.
   Hoeffer, Charles
TI Fecal Corticosterone Levels in RCAN1 Mutant Mice
SO COMPARATIVE MEDICINE
LA English
DT Article
ID DOWN-SYNDROME; CHRONIC STRESS; METABOLIC SYNDROME; MOUSE MODEL;
   NONINVASIVE METHOD; CORTISOL; CALCINEURIN; GLUCOCORTICOIDS; RESPONSES;
   CHILDREN
AB Regulator of calcineurin 1 (RCAN1) is related to the expression of human neurologic disorders such as Down syndrome, Alzheimer disease, and chromosome 21q deletion syndrome. We showed here that RCAN1-knockout mice exhibit reduced innate anxiety as indicated by the elevated-plus maze. To examine whether glucocorticoids contribute to this phenotype, we measured fecal corticosterone in male wildtype and RCAN1-knockout mice and in male and female transgenic mice with neuronal overexpression of RCAN1 (Tg-RCAN1(TG)). We found no difference in fecal corticosterone levels of RCAN1-knockout mice and their wildtype littermates. As expected, we found differences between sexes in fecal corticosterone levels. In addition, we found higher levels of excreted corticosterone in Tg-RCAN1(TG) female mice as compared with female wildtype mice. Our data indicate normal diurnal corticosterone production in RCAN1 mutant mice and do not suggest a causal role in either the cognitive or anxiety phenotypes exhibited by RCAN1-knockout mice.
C1 [Rakowski-Anderson, Tammy; Lavilla, Carmencita; Pullium, Jennifer K.] NYU, Div Lab Anim Resources, New York, NY 10012 USA.
   [Rakowski-Anderson, Tammy; Pullium, Jennifer K.] NYU, Dept Pathol, New York, NY 10016 USA.
   [Wong, Helen; Hoeffer, Charles] NYU, Smilow Neurosci Program, New York, NY USA.
   [Wong, Helen; Hoeffer, Charles] NYU, Sch Med, NYU Langone Med Ctr, Dept Physiol & Neurosci, New York, NY USA.
   [Wong, Helen; Hoeffer, Charles] NYU, Ctr Neural Sci, New York, NY 10003 USA.
   [Rothermel, Beverly] UT SW Med Ctr, Dept Internal Med Cardiol, Dallas, TX USA.
   [Cain, Peter] Excelsior Coll, Dept Psychol, Albany, NY USA.
C3 New York University; New York University; New York University; New York
   University; NYU Langone Medical Center; New York University; University
   of Texas System; University of Texas Southwestern Medical Center Dallas
RP Rakowski-Anderson, T (corresponding author), NYU, Div Lab Anim Resources, New York, NY 10012 USA.
EM rakowt01@nyumc.org
FU NHLBI NIH HHS [R01 HL097768] Funding Source: Medline
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NR 62
TC 4
Z9 4
U1 0
U2 2
PU AMER ASSOC LABORATORY ANIMAL SCIENCE
PI MEMPHIS
PA 9190 CRESTWYN HILLS DR, MEMPHIS, TN 38125 USA
SN 1532-0820
J9 COMPARATIVE MED
JI Comparative Med.
PD APR
PY 2012
VL 62
IS 2
BP 87
EP 94
PG 8
WC Veterinary Sciences; Zoology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences; Zoology
GA 978UZ
UT WOS:000306772600001
PM 22546913
DA 2025-06-11
ER

PT J
AU Kloiber, S
   Kohli, MA
   Brueckl, T
   Ripke, S
   Ising, M
   Uhr, M
   Menke, A
   Unschuld, PG
   Horstmann, S
   Salyakina, D
   Muller-Myhsok, B
   Binder, EB
   Holsboer, F
   Lucae, S
AF Kloiber, S.
   Kohli, M. A.
   Brueckl, T.
   Ripke, S.
   Ising, M.
   Uhr, M.
   Menke, A.
   Unschuld, P. G.
   Horstmann, S.
   Salyakina, D.
   Muller-Myhsok, B.
   Binder, E. B.
   Holsboer, F.
   Lucae, S.
TI Variations in tryptophan hydroxylase 2 linked to decreased serotonergic
   activity are associated with elevated risk for metabolic syndrome in
   depression
SO MOLECULAR PSYCHIATRY
LA English
DT Article
DE depression; metabolic syndrome; TPH2; genetics; serotonin
ID 3RD NATIONAL-HEALTH; MAJOR DEPRESSION; BIPOLAR DISORDER; YOUNG-ADULTS;
   TRYPTOPHAN-HYDROXYLASE-2; EPIDEMIOLOGY; OBESITY; BRAIN; GENE;
   POLYMORPHISMS
AB Major depression and the metabolic syndrome (MetS) are interacting clinical conditions influenced by genetic susceptibility. For both disorders, impaired serotonergic neurotransmission in specific brain areas has been suggested. This led us to investigate whether variants in the gene coding for tryptophan hydroxylase 2 (TPH2), the brain-specific and rate-limiting enzyme for serotonin biosynthesis, might be predictive for an increased liability for the development of MetS in depressed patients. In a case-control study consisting of 988 patients with recurrent unipolar depression (RUD) and 1023 psychiatric healthy controls, MetS components were ascertained according to the International Diabetes Foundation criteria. A total of 41 single nucleotide polymorphisms fully covering the TPH2 gene region were genotyped in stage 1 (300 patients/300 controls), resulting in significant genetic associations of polymorphisms located in exon 7 and intron 8 of TPH2 and the occurrence of MetS in depressed patients after correction for age, gender and multiple testing (51 RUD-MetS/179 RUD-non-MetS). We were able to confirm the significant association of rs17110690 in stage 2 (688 patients/723 controls; 110 RUD-MetS/549 RUD-non-MetS) and to link risk-genotypes and risk-haplotypes for MetS to lower TPH2 mRNA expression and to lower 5-hydroxyindoleacetic acid levels in cerebrospinal fluid previously reported in functional studies. Our findings suggest that TPH2 polymorphisms characterize a subgroup of depressed patients who are especially prone to develop metabolic disorders induced by a genotype-dependent impairment of serotonergic neurotransmission. Identifying depressed patients at high risk for MetS using genetic variants could have direct clinical impact on individualized disease management and prevention strategies. Molecular Psychiatry (2010) 15, 736-747; doi:10.1038/mp.2008.142; published online 6 January 2009
C1 [Kloiber, S.; Kohli, M. A.; Brueckl, T.; Ripke, S.; Ising, M.; Uhr, M.; Menke, A.; Unschuld, P. G.; Horstmann, S.; Salyakina, D.; Muller-Myhsok, B.; Binder, E. B.; Holsboer, F.; Lucae, S.] Max Planck Inst Psychiat, D-80804 Munich, Germany.
C3 Max Planck Society
RP Kloiber, S (corresponding author), Max Planck Inst Psychiat, Kraepelinstr 2-10, D-80804 Munich, Germany.
EM stkloiber@mpipsykl.mpg.de
RI Unschuld, Paul/JTT-4748-2023; Ripke, Stephan/AAK-5486-2021; Kloiber,
   Stefan/AAW-8786-2021; Menke, Andreas/D-5939-2014; Unschuld, Paul
   Gerson/N-7294-2013
OI Salyakina, Daria/0000-0003-3283-3691; Kloiber,
   Stefan/0000-0002-6838-4114; ripke, stephan/0000-0003-3622-835X; Menke,
   Andreas/0000-0002-1498-1992; Unschuld, Paul Gerson/0000-0002-6116-3386
FU Max-Planck Society; Federal Ministry of Education and Research (BMBF)
   [Forderkennzeichen 01GS0481]
FX We thank S Damast, S Sauer, G Ernst-Jansen, G Gajewsky and J Huber for
   their excellent technical assistance. This work was funded by the
   Max-Planck Society and the Federal Ministry of Education and Research
   (BMBF) in the framework of the National Genome Research Network (NGFN),
   Forderkennzeichen 01GS0481. The authors are responsible for the contents
   of this publication.
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NR 71
TC 26
Z9 27
U1 0
U2 7
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1359-4184
EI 1476-5578
J9 MOL PSYCHIATR
JI Mol. Psychiatr.
PD JUL
PY 2010
VL 15
IS 7
BP 736
EP 747
DI 10.1038/mp.2008.142
PG 12
WC Biochemistry & Molecular Biology; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Neurosciences & Neurology; Psychiatry
GA 614LD
UT WOS:000279059400008
PM 19125159
DA 2025-06-11
ER

PT J
AU Zolghadrpour, MA
   Jowshan, MR
   Seyedmahalleh, MH
   Imani, H
   Karimpour, F
   Asghari, S
AF Zolghadrpour, Mohammad-Amin
   Jowshan, Mohammad-Reza
   Seyedmahalleh, Mohammad Heidari
   Imani, Hossein
   Karimpour, Farzad
   Asghari, Somayyeh
TI Consumption of a new developed synbiotic yogurt improves oxidative
   stress status in adults with metabolic syndrome: a randomized controlled
   clinical trial
SO SCIENTIFIC REPORTS
LA English
DT Article
DE Synbiotic yogurt; Probiotic; Metabolic syndrome; Oxidative stress;
   Clinical trial
ID PROBIOTICS; DYSLIPIDEMIA; MICROBIOTA; PLASMA
AB Association between metabolic syndrome (MetS) and oxidative stress has been shown in numerous studies. It has been shown that probiotics could be the effective treatment strategy in improving oxidative stress. This study aimed to determine the effects of a new developed synbiotic yogurt on oxidative stress status in adults with MetS. Forty-four individuals were assigned into two groups and given 300 g of synbiotic yogurt containing Lactobacillus plantarum, Lactobacillus pentosus, and Chloromyces marcosianos yeast or regular yogurt for 12 weeks in this randomized, placebo-controlled clinical trial. Before and after the intervention, biochemical parameters were assessed. Daily consumption of synbiotic yogurt in adults with MetS showed a statistically significant improvement in the level of glutathione peroxidase (p = 0.01) and total oxidant status (p = 0.006) compared to the regular yogurt. Total Antioxidant Capacity and superoxide dismutase levels increased significantly (p = 0.002 and p = 0.02, respectively) in the intervention group compared to the baseline levels. In adults with MetS, daily consumption of the synbiotic yogurt containing native strains of Lactobacillus plantarum, Lactobacillus pentosus, and Chloromyces marcosianos yeast for 12 weeks was associated with improvements in oxidative stress status.Trial registration number: Iranian Registry of Clinical Trials (IRCT20220426054667N1) (18/05/2022)
C1 [Zolghadrpour, Mohammad-Amin; Jowshan, Mohammad-Reza; Imani, Hossein; Asghari, Somayyeh] Univ Tehran Med Sci, Fac Nutr Sci & Dietet, Sch Nutr Sci & Dietet, Dept Clin Nutr, 44 Hojjatdoust St,Naderi St,Keshavarz Blvd, Tehran 141556117, Iran.
   [Seyedmahalleh, Mohammad Heidari] Univ Tehran Med Sci, Dept Community Nutr, Sch Nutr Sci & Dietet, Tehran, Iran.
   [Karimpour, Farzad] Yasuj Univ Med Sci, Social Determinants Hlth Res Ctr, Yasuj, Iran.
C3 Tehran University of Medical Sciences; Tehran University of Medical
   Sciences; Yasouj University
RP Asghari, S (corresponding author), Univ Tehran Med Sci, Fac Nutr Sci & Dietet, Sch Nutr Sci & Dietet, Dept Clin Nutr, 44 Hojjatdoust St,Naderi St,Keshavarz Blvd, Tehran 141556117, Iran.; Karimpour, F (corresponding author), Yasuj Univ Med Sci, Social Determinants Hlth Res Ctr, Yasuj, Iran.
EM saverzida@yahoo.com; asghari.nut@gmail.com
RI Jowshan, Mohammadreza/ACQ-6216-2022; Imani, Hossein/AAU-7884-2020
OI Jowshan, Mohammad-Reza/0000-0001-8603-5674
FU Tehran University of Medical Sciences, Tehran, Iran
FX We thank the research vice-chancellor of Tehran University of Medical
   Sciences, Tehran, Iran, for the financial support and the subjects who
   participated in the current study.
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NR 47
TC 4
Z9 4
U1 0
U2 0
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD SEP 2
PY 2024
VL 14
IS 1
AR 20333
DI 10.1038/s41598-024-71264-y
PG 8
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA E6R2V
UT WOS:001304252300017
PM 39223205
OA gold
DA 2025-06-11
ER

PT J
AU Agius, R
   Pace, NP
   Fava, S
AF Agius, Rachel
   Pace, Nikolai Paul
   Fava, Stephen
TI Reduced leukocyte mitochondrial copy number in metabolic syndrome and
   metabolically healthy obesity
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Article
DE mitochondrial DNA copy number; obesity; metabolic syndrome; insulin
   resistance; metabolic health
ID UNHEALTHY NORMAL-WEIGHT; FASTING PLASMA-GLUCOSE; ALL-CAUSE MORTALITY;
   DNA CONTENT; INSULIN-RESISTANCE; OXIDATIVE STRESS; ADIPOSE-TISSUE;
   RISK-FACTOR; ASSOCIATION; EXPRESSION
AB ObjectiveThis study aimed to investigate the associations between peripheral blood leukocyte mitochondrial copy number, metabolic syndrome, and adiposity-related body composition phenotypes in a high prevalence population. MethodsA single center cross-sectional study was conducted, consisting of 521 middle-aged subjects of Maltese-Caucasian ethnicity. Participants were stratified according to the presence of metabolic syndrome and different metabolic health definitions based on NCEP-ATP III criteria. Relative leukocyte mitochondrial DNA copy number was determined by quantitative polymerase chain reaction and corrected for leukocyte and platelet count. The associations between mitochondrial copy number and metabolic syndrome components was evaluated and adjusted for age and gender. ResultsSignificant negative correlations between mtDNA copy number and BMI, waist circumference, triglyceride levels, fasting plasma glucose, HbA1c, HOMA-IR and hsCRP were observed, along with a positive correlation with HDL-C levels. Mitochondrial copy number was lower in individuals with metabolic syndrome. When compared to metabolically healthy normal weight subjects, a reduction in mtDNA copy number was observed in both the metabolically healthy and unhealthy obese categories. ConclusionOur data supports the association between reduced leukocyte mtDNA copy number, obesity, and metabolic syndrome. This investigation expands on the spectrum of associations between mtDNA copy number and metabolic phenotypes in different populations and underpins the role of mitochondrial dysfunction in the development and progression of metabolic syndrome and its components.
C1 [Agius, Rachel; Pace, Nikolai Paul; Fava, Stephen] Univ Malta, Fac Med & Surg, Msida, Malta.
   [Agius, Rachel; Fava, Stephen] Mater Dei Hosp, Dept Med, Msida, Malta.
   [Pace, Nikolai Paul] Univ Malta, Ctr Mol Med & Biobanking, Msida, Malta.
C3 University of Malta; University of Malta
RP Pace, NP (corresponding author), Univ Malta, Fac Med & Surg, Msida, Malta.; Pace, NP (corresponding author), Univ Malta, Ctr Mol Med & Biobanking, Msida, Malta.
EM nikolai.p.pace@um.edu.mt
RI Fava, S/D-8599-2012; Pace, Nikolai/AAY-2233-2021
OI Pace, Nikolai Paul/0000-0002-7332-874X
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NR 89
TC 14
Z9 15
U1 1
U2 8
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD JUL 25
PY 2022
VL 13
AR 886957
DI 10.3389/fendo.2022.886957
PG 13
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 3P9AL
UT WOS:000837825600001
PM 35957819
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Chen, W
   Guo, JX
   Zhang, YZ
   Zhang, J
AF Chen, Wen
   Guo, Junxia
   Zhang, Yanzhen
   Zhang, Jing
TI The beneficial effects of taurine in preventing metabolic syndrome
SO FOOD & FUNCTION
LA English
DT Review
ID HIGH-FAT DIET; IMPROVES INSULIN SENSITIVITY; FARNESOID X RECEPTOR;
   HIGH-CHOLESTEROL; OXIDATIVE STRESS; BILE-ACIDS; IMMUNOHISTOCHEMICAL
   LOCALIZATION; ALVEOLAR MACROPHAGES; ANTIOXIDANT ACTIVITY;
   GLUCOSE-HOMEOSTASIS
AB Metabolic syndrome, a cluster of risk factors for diabetes and cardiovascular disease, has become a very serious public health concern. A number of studies have provided evidence that taurine has an efficient action against metabolic syndrome, which includes reducing triglycerides to prevent obesity, improving insulin resistance to regulate glucose metabolism, lowering cholesterol (especially decreasing VLDL + LDL cholesterol and increasing HDL cholesterol) to prevent diet-induced hypercholesterolemia, and regulating the renin-angiotensin-aldosterone system and the kallikrein-kinin system etc. to reduce blood pressure. This review summarizes the data from in vitro, animal and limited human studies of beneficial effects of taurine on obesity, dyslipidaemia, diabetes mellitus and hypertension, and addresses the possible metabolic and molecular mechanisms of the prevention of metabolic syndrome by taurine.
C1 [Chen, Wen; Guo, Junxia; Zhang, Yanzhen; Zhang, Jing] Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Foods, Beijing 100191, Peoples R China.
C3 Beijing Union University
RP Chen, W (corresponding author), Beijing Union Univ, Beijing Key Lab Bioact Subst & Funct Foods, Beijing 100191, Peoples R China.
EM wlchenwen@buu.edu.cn; junxia@buu.edu.cn; yanzhen@-buu.edu.cn;
   zhangjing1@-buu.edu.cn
RI Zhang, Yanzhen/L-6446-2018
FU Beijing Natural Science Foundation [5142004]; National Natural Science
   Foundation for Young Scholars of China [31401501]
FX This work was supported by Beijing Natural Science Foundation (Grant No.
   5142004) and the National Natural Science Foundation for Young Scholars
   of China (Grant No. 31401501).
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NR 146
TC 63
Z9 68
U1 0
U2 46
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PY 2016
VL 7
IS 4
BP 1849
EP 1863
DI 10.1039/c5fo01295c
PG 15
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA DK3BM
UT WOS:000374790000014
PM 26918249
DA 2025-06-11
ER

PT J
AU Hansen, E
   Hajri, T
   Abumrad, NN
AF Hansen, Erik
   Hajri, Tahar
   Abumrad, Naji N.
TI Is all fat the same? The role of fat in the pathogenesis of the
   metabolic syndrome and type 2 diabetes mellitus
SO SURGERY
LA English
DT Review
ID INSULIN-RESISTANCE; ADIPOSE-TISSUE; VISCERAL OBESITY; OXIDATIVE STRESS;
   INFLAMMATION; ADIPOGENESIS; POPULATION; DEPOTS
C1 Vanderbilt Univ, Sch Med, Dept Surg, Nashville, TN 37232 USA.
C3 Vanderbilt University
RP Abumrad, NN (corresponding author), Vanderbilt Univ, Sch Med, Dept Surg, D-4313 Med Ctr N,1161 21st Ave S, Nashville, TN 37232 USA.
EM Naji.Abumrad@Vanderbilt.edu
RI Hajri, Tahar/AAQ-6499-2020
OI Hajri, Tahar/0000-0003-3805-3717
FU NIDDK NIH HHS [R01 DK070860] Funding Source: Medline
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   2005, IDF CONSENSUS WORLDW
NR 32
TC 32
Z9 38
U1 0
U2 2
PU MOSBY, INC
PI ST LOUIS
PA 11830 WESTLINE INDUSTRIAL DR, ST LOUIS, MO 63146-3318 USA
SN 0039-6060
J9 SURGERY
JI Surgery
PD JUN
PY 2006
VL 139
IS 6
BP 711
EP 716
DI 10.1016/j.surg.2005.10.018
PG 6
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA 060LS
UT WOS:000238804300001
PM 16782424
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Gurusamy, J
   Gandhi, S
   Damodharan, D
   Ganesan, V
   Palaniappan, M
AF Gurusamy, Jothimani
   Gandhi, Sailaxmi
   Damodharan, Dinakaran
   Ganesan, Venkatasubramanian
   Palaniappan, Marimuthu
TI Exercise, diet and educational interventions for metabolic syndrome in
   persons with schizophrenia: A systematic review
SO ASIAN JOURNAL OF PSYCHIATRY
LA English
DT Review
DE Metabolic syndrome; Exercise; Diet; Psychoeducation; Schizophrenia;
   Weight reduction
ID COGNITIVE-BEHAVIORAL THERAPY; WEIGHT MANAGEMENT PROGRAM; SEVERE
   MENTAL-ILLNESS; PHYSICAL-ACTIVITY; GAIN; OBESITY; RISK; INDIVIDUALS;
   NEED
AB Introduction: Individuals with major psychotic disorders such as schizophrenia are at increased risk for developing metabolic syndrome due to lifestyle-and treatment-related factors. Numerous interventions have been tested in inpatient and outpatient mental health settings to decrease risk factors. Diet and exercise represent the mainstay of weight loss treatment. With this background the review aimed to evaluate the effects of psychoeducation, diet and physical activity interventions on reduction of metabolic syndrome risk factors such as BMI, Body weight, biochemical profiles in schizophrenia.
   Methods: The authors conducted database searches of PsychINFO, MEDLINE, Pubmed, Proquest, EBSCO and the Cochrane Database of Systematic Reviews, and manual searches from 1968 to 2017. Search indentified 11 studies that met the inclusion criteria. Study quality was critically appraised by 2 reviewers using established criteria. The outcome measures were body mass index, body weight, waist circumference, lipid profile, fasting glucose.
   Results: Interventions led to significant weight reduction (8 studies), reduced body mass index (5 studies), decreased waist circumference (4 studies) and lower blood glucose levels (5 studies). Dietician and nurse led interventions (6 studies). The studies showed non pharmacological interventions were effective in reducing risk factors.
   Conclusion: This review was able to demonstrate effectiveness of peychoeducation, diet and physical activity interventions were helpful to decrease and manage antipsychotic-induced weight gain. Results showed lifestyle interventions are safer and effective for promoting decrease or maintenance of weight and it can be delivered at low cost, safe and improves quality of life.
C1 [Gurusamy, Jothimani; Gandhi, Sailaxmi] Natl Inst Mental Hlth & Neurosci, Dept Nursing, Bangalore, Karnataka, India.
   [Damodharan, Dinakaran; Ganesan, Venkatasubramanian] Natl Inst Mental Hlth & Neurosci, Dept Psychiat, Bangalore, Karnataka, India.
   [Palaniappan, Marimuthu] Natl Inst Mental Hlth & Neurosci, Dept Bioststat, Bangalore, Karnataka, India.
C3 National Institute of Mental Health & Neurosciences - India; National
   Institute of Mental Health & Neurosciences - India; National Institute
   of Mental Health & Neurosciences - India
RP Gandhi, S (corresponding author), Natl Inst Mental Hlth & Neurosci, Dept Nursing, Bangalore, Karnataka, India.
EM sailaxmi63@yahoo.com
RI Gandhi, Sailaxmi/Q-9122-2019; Gurusamy, Jothimani/P-6729-2019;
   Venkatasubramanian, Ganesan/AAD-9117-2019
OI Gurusamy, Jothimani/0000-0002-3844-6038; Marimuthu,
   Palaniappan/0000-0002-0029-3216; Venkatasubramanian,
   Ganesan/0000-0002-0949-898X
CR Alvarez-Jiménez M, 2008, BRIT J PSYCHIAT, V193, P101, DOI 10.1192/bjp.bp.107.042853
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NR 44
TC 61
Z9 65
U1 0
U2 44
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1876-2018
EI 1876-2026
J9 ASIAN J PSYCHIATR
JI Asian J. Psychiatr.
PD AUG
PY 2018
VL 36
BP 73
EP 85
DI 10.1016/j.ajp.2018.06.018
PG 13
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychiatry
GA GV6TV
UT WOS:000446249900026
PM 29990631
DA 2025-06-11
ER

PT J
AU Tajaddini, A
   Roshanravan, N
   Mobasseri, M
   Aeinehchi, A
   Azar, PSM
   Hadi, A
   Ostadrahimi, A
AF Tajaddini, Aynaz
   Roshanravan, Neda
   Mobasseri, Majid
   Aeinehchi, Aydin
   Azar, Pouria Sefid-Mooye
   Hadi, Amir
   Ostadrahimi, Alireza
TI Saffron improves life and sleep quality, glycaemic status, lipid profile
   and liver function in diabetic patients: A double-blind,
   placebo-controlled, randomised clinical trial
SO INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
LA English
DT Article
ID CROCUS-SATIVUS-L.; TO-MODERATE DEPRESSION; OXIDATIVE STRESS; SEXUAL
   DYSFUNCTION; INSULIN-RESISTANCE; METABOLIC SYNDROME; OF-LIFE; EXTRACT;
   MELLITUS; VERSION
AB Background Type 2 diabetes (T2D) is a metabolic disorder that is related to hyperglycaemia, hyperlipidaemia and liver dysfunction and has detrimental effects on a patient's mental health. Hence, the current study investigated the effects of saffron supplementation on dietary intake, anthropometric measures, mood, sleep quality and metabolic biomarkers in overweight/obese patients with T2D.
   Methods In a double-blind, randomised controlled trial, 70 overweight/obese patients with T2D were randomly allocated to two groups and received 100 mg/day saffron or placebo for 8 weeks. Participants completed the Beck depression inventory-II (BDI-II), Hurlbert index of sexual desire (HISD), Pittsburgh Sleep Quality Index (PSQI) and Diabetes-specific Quality-of-Life Brief Clinical Inventory questionnaires (DQOL-BCI). Dietary intake, anthropometric measures, fasting plasma glucose (FPG), haemoglobin A1C (HbA1C), insulin, lipid profile and liver enzymes were determined at baseline and the end of the study.
   Results At the end of the eighth week, saffron supplementation significantly decreased FPG, triglyceride (TG), insulin, aspartate aminotransferase (AST) and alanine aminotransferase (ALT) (P < .001). Moreover, significant improvements in BDI-II scores and total quality of life were observed in the intervention group (P < .001). The saffron group showed more significant improvements in PSQI scores than the placebo group, such that at the post-intervention analysis, only the saffron group achieved a "good" sleep band. At this relatively high dose, saffron supplementation improved glycaemic status, lipid profile and liver enzyme measures in patients with T2D while also improving sleep and overall quality of life.
   Conclusion Our results indicate that saffron notably reduced hyperglycaemia and hyperlipidaemia and improved liver function in patients with T2D in an 8-week randomised clinical trial. Saffron also significantly improved depression, sleep quality and overall quality of life in diabetic patients. However, further investigation is necessary to confirm whether saffron is an effective complementary therapy for T2D.
C1 [Tajaddini, Aynaz; Ostadrahimi, Alireza] Tabriz Univ Med Sci, Nutr Res Ctr, Tabriz, Iran.
   [Roshanravan, Neda] Tabriz Univ Med Sci, Cardiovasc Res Ctr, Tabriz, Iran.
   [Mobasseri, Majid] Tabriz Univ Med Sci, Endocrinol Res Ctr, Tabriz, Iran.
   [Aeinehchi, Aydin; Azar, Pouria Sefid-Mooye] Tabriz Univ Med Sci, Student Res Comm, Tabriz, Iran.
   [Hadi, Amir] Isfahan Univ Med Sci, Food Secur Res Ctr, Sch Nutr & Food Sci, Dept Clin Nutr, Esfahan, Iran.
C3 Tabriz University of Medical Science; Tabriz University of Medical
   Science; Tabriz University of Medical Science; Tabriz University of
   Medical Science; Isfahan University of Medical Sciences
RP Ostadrahimi, A (corresponding author), Tabriz Univ Med Sci, Nutr Fac, Nutr Res Ctr, Dept Clin Nutr, Tabriz, Iran.
EM ostadrahimi@tbzmed.ac.ir
RI Hadi, Amir/AAK-4634-2020; Sefidmooye Azar, Pouria/ABG-1534-2021
OI Tajaddini, Aynaz/0000-0002-9113-499X
FU Nutrition Research Centre, Tabriz University of Medical Sciences
FX This trial was funded by the vice-chancellor for research at the
   Nutrition Research Centre, Tabriz University of Medical Sciences
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NR 47
TC 37
Z9 37
U1 0
U2 11
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1368-5031
EI 1742-1241
J9 INT J CLIN PRACT
JI Int. J. Clin. Pract.
PD AUG
PY 2021
VL 75
IS 8
AR e14334
DI 10.1111/ijcp.14334
EA MAY 2021
PG 11
WC Medicine, General & Internal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Pharmacology & Pharmacy
GA TL5LO
UT WOS:000654222200001
PM 33960081
DA 2025-06-11
ER

PT J
AU Machado, MO
   Veronese, N
   Sanches, M
   Stubbs, B
   Koyanagi, A
   Thompson, T
   Tzoulaki, I
   Solmi, M
   Vancampfort, D
   Schuch, FB
   Maes, M
   Fava, GA
   Ioannidis, JPA
   Carvalho, AF
AF Machado, Myrela O.
   Veronese, Nicola
   Sanches, Marcos
   Stubbs, Brendon
   Koyanagi, Ai
   Thompson, Trevor
   Tzoulaki, Ioanna
   Solmi, Marco
   Vancampfort, Davy
   Schuch, Felipe B.
   Maes, Michael
   Fava, Giovanni A.
   Ioannidis, John P. A.
   Carvalho, Andre F.
TI The association of depression and all-cause and cause-specific
   mortality: an umbrella review of systematic reviews and meta-analyses
SO BMC MEDICINE
LA English
DT Review
DE Depression; Mortality; All-cause; Cause-specific; Systematic reviews;
   Meta-analyses; Survival; Umbrella review; Psychiatry
ID ENVIRONMENTAL RISK-FACTORS; ACUTE CORONARY SYNDROME; SEVERE
   MENTAL-ILLNESS; EXCESS MORTALITY; PROGNOSTIC ASSOCIATION;
   MYOCARDIAL-INFARCTION; CARDIOVASCULAR EVENTS; HEART-FAILURE; METABOLIC
   SYNDROME; BIPOLAR DISORDER
AB Background: Depression is a prevalent and disabling mental disorder that frequently co-occurs with a wide range of chronic conditions. Evidence has suggested that depression could be associated with excess all-cause mortality across different settings and populations, although the causality of these associations remains unclear.
   Methods: We conducted an umbrella review of systematic reviews and meta-analyses of observational studies. PubMed, PsycINFO, and Embase electronic databases were searched through January 20, 2018. Systematic reviews and meta-analyses that investigated associations of depression and all-cause and cause-specific mortality were selected for the review. The evidence was graded as convincing, highly suggestive, suggestive, or weak based on quantitative criteria that included an assessment of heterogeneity, 95% prediction intervals, small-study effects, and excess significance bias.
   Results: A total of 26 references providing 2 systematic reviews and data for 17 meta-analytic estimates met inclusion criteria (19 of them on all-cause mortality); data from 246 unique studies (N = 3,825,380) were synthesized. All 17 associations had P < 0.05 per random effects summary effects, but none of them met criteria for convincing evidence. Associations of depression and all-cause mortality in patients after acute myocardial infarction, in individuals with heart failure, in cancer patients as well as in samples from mixed settings met criteria for highly suggestive evidence. However, none of the associations remained supported by highly suggestive evidence in sensitivity analyses that considered studies employing structured diagnostic interviews. In addition, associations of depression and all-cause mortality in cancer and post-acute myocardial infarction samples were supported only by suggestive evidence when studies that tried to adjust for potential confounders were considered.
   Conclusions: Even though associations between depression and mortality have nominally significant results in all assessed settings and populations, the evidence becomes weaker when focusing on studies that used structured interviews and those that tried to adjust for potential confounders. A causal effect of depression on all-cause and cause-specific mortality remains unproven, and thus interventions targeting depression are not expected to result in lower mortality rates at least based on current evidence from observational studies.
C1 [Machado, Myrela O.] Univ Fed Ceara, Fac Med, Dept Clin Med, BR-60430140 Fortaleza, CE, Brazil.
   [Machado, Myrela O.] Univ Fed Ceara, Fac Med, Translat Psychiat Res Grp, BR-60430140 Fortaleza, CE, Brazil.
   [Veronese, Nicola; Stubbs, Brendon; Solmi, Marco] Inst Clin Res & Educ Med IREM, I-35128 Padua, Italy.
   [Veronese, Nicola] CNR, Aging Branch, Neurosci Inst, I-35128 Padua, Italy.
   [Sanches, Marcos] CAMH, Biostat Consulting Unit, Toronto, ON, Canada.
   [Stubbs, Brendon] South London & Maudsley NHS Fdn Trust, Denmark Hill, London SE5 8AZ, England.
   [Stubbs, Brendon] Kings Coll London, Inst Psychiat Psychol & Neurosci IoPPN, Crespigny Pk, London AF SE58, England.
   [Stubbs, Brendon] Anglia Ruskin Univ, Fac Hlth Social Care & Educ, Chelmsford CM1 1SQ, Essex, England.
   [Koyanagi, Ai] Univ Barcelona, Parc Sanitari St Joan Deu, Fundacio St Joan Deu CIBERSAM, Barcelona 08950, Spain.
   [Thompson, Trevor] Univ Greenwich, Fac Educ & Hlth, London SE10 9LS, England.
   [Tzoulaki, Ioanna] Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, London W2 1PG, England.
   [Tzoulaki, Ioanna] Imperial Coll London, Sch Publ Hlth, MRC PHE Ctr Environm, London W2 1PG, England.
   [Tzoulaki, Ioanna] Univ Ioannina, Med Sch, Dept Hyg & Epidemiol, Ioannina, Greece.
   [Solmi, Marco] Univ Padua, Dept Neurosci, I-35100 Padua, Italy.
   [Vancampfort, Davy] Univ Leuven, KU Leuven, Dept Rehabil Sci, B-3001 Heverlee, Belgium.
   [Vancampfort, Davy] Univ Leuven, KU Leuven, Univ Psychiat Ctr, B-3070 Leuven, Kortenberg, Belgium.
   [Schuch, Felipe B.] Ctr Univ Salle, Canoas, Brazil.
   [Schuch, Felipe B.] Hosp Clin Porto Alegre, Porto Alegre, RS, Brazil.
   [Maes, Michael] Chulalongkorn Univ, Fac Med, Dept Psychiat, Bangkok 10330, Thailand.
   [Maes, Michael] Deakin Univ, Barwon Hlth, IMPACT Strateg Res Ctr, Geelong, Vic, Australia.
   [Fava, Giovanni A.] Univ Bologna, Dept Psychol, Viale Berti Pichat 5, I-40127 Bologna, Italy.
   [Fava, Giovanni A.] Erie Cty Med Ctr & Labs, Dept Psychiat, 462 Grider St, Buffalo, NY 14215 USA.
   [Ioannidis, John P. A.] Stanford Univ, Dept Med, Palo Alto, CA 94305 USA.
   [Ioannidis, John P. A.] Stanford Univ, Dept Hlth Res & Policy, Palo Alto, CA 94305 USA.
   [Ioannidis, John P. A.] Stanford Univ, Dept Stat, Palo Alto, CA 94305 USA.
   [Ioannidis, John P. A.] Stanford Univ, Dept Meta Res Innovat Ctr Stanford METRICS, Palo Alto, CA 94305 USA.
   [Carvalho, Andre F.] Univ Toronto, Dept Psychiat, Toronto, ON, Canada.
   [Carvalho, Andre F.] CAMH, 33 Russel St,Room RS1050S, Toronto, ON M5S 2S1, Canada.
C3 Universidade Federal do Ceara; Universidade Federal do Ceara; Consiglio
   Nazionale delle Ricerche (CNR); University of Toronto; Centre for
   Addiction & Mental Health - Canada; Anglia Ruskin University; University
   of Barcelona; University of Greenwich; Imperial College London; Imperial
   College London; University of Ioannina; University of Padua; KU Leuven;
   KU Leuven; Hospital de Clinicas de Porto Alegre; Chulalongkorn
   University; Barwon Health; Deakin University; University of Bologna;
   Stanford University; Stanford University; Stanford University; Stanford
   University; University of Toronto; University of Toronto; Centre for
   Addiction & Mental Health - Canada
RP Carvalho, AF (corresponding author), Univ Toronto, Dept Psychiat, Toronto, ON, Canada.; Carvalho, AF (corresponding author), CAMH, 33 Russel St,Room RS1050S, Toronto, ON M5S 2S1, Canada.
EM andre.carvalho@camh.ca
RI solmi, marco/K-3906-2018; Sanches, Marcos/ADC-0738-2022; Tzoulaki,
   Ioanna/ABE-6269-2020; Stubbs, Brendon/X-1904-2018; Carvalho,
   Andre/AEZ-4001-2022; Schuch, Felipe/AAF-5028-2019; Veronese,
   Nicola/K-4343-2018; Ioannidis, John/G-9836-2011; Vancampfort,
   Davy/AAD-1987-2019; Maes, Michael/B-8546-2011; Stubbs,
   Brendon/C-5696-2015; Schuch, Felipe/L-4620-2016; Koyanagi,
   Ai/D-3833-2018
OI Thompson, Trevor/0000-0001-9880-782X; Ioannidis, John
   P./0000-0003-3118-6859; Tzoulaki, Ioanna/0000-0002-4275-9328; Stubbs,
   Brendon/0000-0001-7387-3791; Schuch, Felipe/0000-0002-5190-4515; solmi,
   marco/0000-0003-4877-7233; Koyanagi, Ai/0000-0002-9565-5004; Sanches,
   Marcos/0000-0001-9075-1761; Maes, Michael/0000-0002-2012-871X
FU Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES,
   Brazil); Miguel Servet [CP13/00150, PI15/00862]; ISCIII - General Branch
   Evaluation and Promotion of Research; European Regional Development Fund
   (ERDF-FEDER)
FX CAK is supported by a postdoctoral research fellowship from the
   Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES,
   Brazil). AK's work was supported by the Miguel Servet contract financed
   by the CP13/00150 and PI15/00862 projects, integrated into the National
   R + D + I and funded by the ISCIII - General Branch Evaluation and
   Promotion of Research - and the European Regional Development Fund
   (ERDF-FEDER).
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NR 97
TC 172
Z9 176
U1 1
U2 32
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1741-7015
J9 BMC MED
JI BMC Med.
PD JUL 20
PY 2018
VL 16
AR 112
DI 10.1186/s12916-018-1101-z
PG 13
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA GN9GU
UT WOS:000439499900001
PM 30025524
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Khan, UI
   Shah, S
   Qureshi, A
   Viswanathan, S
   Merchant, AT
   Virani, SS
   Wylie-Rosett, J
   Noornabi, Y
AF Khan, Unab I.
   Shah, Sabeen
   Qureshi, Asra
   Viswanathan, Shankar
   Merchant, Anwar T.
   Virani, Salim S.
   Wylie-Rosett, Judith
   Noornabi, Yasmeen
TI Burden of cardiometabolic diseases and depression in a low-income, urban
   community in Pakistan: a cross-sectional survey
SO BMC PUBLIC HEALTH
LA English
DT Article
DE Cardiometabolic diseases; Cardiometabolic multimorbidity; Depression;
   Urban community; Low-middle income country
ID MULTIMORBIDITY; ASSOCIATION; ACCURACY
AB Background With the rising epidemic of cardiometabolic diseases (CMDs) in low- and middle-income countries, urban populations face unique challenges such as poor sanitation, environmental pollution, and limited access to healthcare. This study estimates the point prevalence of CMDs and associated risk factors in adults in Karachi, analyses CMD prevalence by sex, and explores the relationship between CMDs and depression. Methods A door-to-door survey was conducted in a densely populated urban community within a 0.5 km radius of a primary health centre. A minimum of 1,480 families were required to estimate the prevalence of CMDs. Depression was screened using PHQ-2 and assessed with PHQ-9. Descriptive analyses summarized family-level sociodemographic data. Sex-specific differences in CMD-related risk factors were analysed using chi(2) and t-tests. Point prevalence and 95% confidence intervals (CIs) for CMDs were calculated. Bivariate analyses compared cardiometabolic risk factors, healthcare utilization, and mental health across CMD categories. Logistic regression assessed associations between CMDs, demographics, risk factors, and depression. Results Of the 1,513 families that participated, 3051 adults were included in the analyses. In this stable community (60% residing for more than five years), there was high Urdu (91%) and English (76%) literacy. There was high cell phone ownership (90%) and internet use (81%). Hypertension was the most prevalent CMD (34%). The likelihood of CMD increased with age, rising 49.39 times (95% CI: 30.21 - 80.74; p: < 0.001) higher in those 60 years and above than those aged 18-29. CMD prevalence was strongly associated with depression, compared to those with no CMDs, there were significantly higher odds of mild (OR: 1.89; 95% CI: 1.28 - 2.78; p: < 0.001) and moderate (OR: 2.21; 95%CI: 1.17 - 4.17; p: < 0.014) depression among participants with CMDs. Median health expenditure was 14.2% (IQR: 11.4-26.7%) of monthly income, with increasing CMD burden linked to higher rates of delay in purchasing medications (p: < 0.001). Conclusion This study highlights the significant burden of CMDs, multimorbidity, and depression in a low-income urban community in Pakistan. The findings suggest that a cardiometabolic multimorbidity (CMM) epidemic is emerging in urban Pakistan, emphasizing the need for integrated interventions addressing physical, mental, economic, and environmental factors in CMD management.
C1 [Khan, Unab I.; Shah, Sabeen; Qureshi, Asra; Noornabi, Yasmeen] Aga Khan Univ, Dept Family Med, Karachi, Sindh, Pakistan.
   [Viswanathan, Shankar] UMass Chan Med Sch Baystate, Dept Healthcare Delivery & Populat Sci, Springfield, MA USA.
   [Merchant, Anwar T.] Univ South Carolina, Dept Epidemiol & Biostat, Columbia, SC USA.
   [Virani, Salim S.] Aga Khan Univ, Dept Med, Karachi, Sindh, Pakistan.
   [Wylie-Rosett, Judith] Albert Einstein Coll Med, Dept Epidemiol & Populat Hlth, Bronx, NY USA.
C3 Aga Khan University; University of Massachusetts System; University of
   Massachusetts Worcester; University of South Carolina System; University
   of South Carolina Columbia; Aga Khan University; Montefiore Medical
   Center; Albert Einstein College of Medicine; Yeshiva University
RP Khan, UI (corresponding author), Aga Khan Univ, Dept Family Med, Karachi, Sindh, Pakistan.
EM unab.khan@aku.edu
OI Khan, Unab/0000-0002-7002-1726
FU Aga Khan University Provost & Vice President Academic Prof. Carl Amrhein
FX The authors would like to thank and acknowledge former Aga Khan
   University Provost & Vice President Academic Prof. Carl Amrhein and Dean
   Medical College Adil Haider for their valuable support for FMHC funding.
   We are very grateful to the local stakeholders for giving permission/s
   to survey families. We would also like to acknowledge our research team
   coordinator Mr. Shamsuddin Tajjudin for planning field visits,
   permissions, and field monitoring. We also thank and appreciate our
   health workers for their support in data collection and field logistics.
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NR 39
TC 0
Z9 0
U1 0
U2 0
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2458
J9 BMC PUBLIC HEALTH
JI BMC Public Health
PD FEB 24
PY 2025
VL 25
IS 1
AR 757
DI 10.1186/s12889-025-21939-6
PG 11
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA Y5S9D
UT WOS:001432728600013
PM 39994704
OA gold, Green Accepted
DA 2025-06-11
ER

PT J
AU Skott, JW
   Lauritsen, J
   Kreiberg, M
   Daugaard, G
   Bandak, M
AF Skott, Julie Wang
   Lauritsen, Jakob
   Kreiberg, Michael
   Daugaard, Gedske
   Bandak, Mikkel
TI Quality of Life in Long-Term Testicular Cancer Survivors With
   Compensated Leydig Cell Dysfunction
SO CLINICAL GENITOURINARY CANCER
LA English
DT Article
DE Late effects; Subclinical hypogonadism; Testicular cancer; Testosterone;
   Testosterone substitution
ID STIMULATING-HORMONE LEVELS; SERUM TESTOSTERONE LEVELS; METABOLIC
   SYNDROME; SEXUAL FUNCTION; HYPOGONADISM; FATIGUE; INSTRUMENT; IMPACT;
   MEN
AB To clarify if testicular cancer (TC) survivors with compensated Leydig cell (LC) dysfunction have impaired quality of life, we studied 147 long-term survivors of TC and analyzed quality-of-life outcomes. Sixty TC survivors had compensated LC dysfunction, and 87 TC survivors had normal LC function. Compensated LC dysfunction in TC survivors was not associated with impaired overall self-evaluated quality of life.
   Background: Compensated Leydig cell (LC) dysfunction, defined by elevated serum levels of luteinizing hormone (LH) in combination with normal total testosterone levels, is common in testicular cancer (TC) survivors. The association between this condition and quality of life is unknown. We aimed to clarify if TC survivors with compensated LC dysfunction have impaired quality of life. Patients and Methods: In total, 147 long-term TC survivors were included. On the basis of a single measurement of testosterone and LH, compensated LC dysfunction was defined by age-adjusted levels of LH above normal range combined with testosterone levels within the normal range. Quality-of-life outcomes including sexual function, anxiety and depression, fatigue, and overall self-evaluated quality of life were compared between patients with and without compensated LC dysfunction with adjustment for age. Results: In total, 60 TC survivors had compensated LC dysfunction and 87 TC survivors had normal LC function. TC survivors with compensated LC dysfunction had lower serum levels of total testosterone (11 vs. 13 nmol/L, P= .016). There were no significant differences in the investigated quality-of-life outcomes (anxiety, depression, sexual function, fatigue) between the 2 groups. Conclusion: Compensated LC dysfunction in TC survivors was not associated with symptoms of depression, anxiety, sexual dysfunction, fatigue, or impaired overall self-evaluated quality of life. Limitations include the few cases of symptoms of depression (n = 7). Our findings do not suggest that testosterone substitution is indicated in TC survivors with compensated LC dysfunction. (C) 2018 Elsevier Inc. All rights reserved.
C1 [Skott, Julie Wang; Lauritsen, Jakob; Kreiberg, Michael; Daugaard, Gedske; Bandak, Mikkel] Copenhagen Univ Hosp, Rigshosp, Dept Oncol, DK-2100 Copenhagen, Denmark.
C3 Rigshospitalet; University of Copenhagen; Copenhagen University Hospital
RP Skott, JW (corresponding author), Copenhagen Univ Hosp, Rigshosp, Dept Oncol, DK-2100 Copenhagen, Denmark.
EM julie.wang.skoett.01@regionh.dk
RI Lauritsen, Jakob/AAG-1987-2019; Daugaard, Gedske/AAD-4009-2019
OI Kreiberg, Michael/0000-0001-5611-5163
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NR 29
TC 6
Z9 6
U1 0
U2 1
PU CIG MEDIA GROUP, LP
PI DALLAS
PA 3500 MAPLE AVENUE, STE 750, DALLAS, TX 75219-3931 USA
SN 1558-7673
EI 1938-0682
J9 CLIN GENITOURIN CANC
JI Clin. Genitourin. Cancer
PD FEB
PY 2019
VL 17
IS 1
BP E65
EP E71
DI 10.1016/j.clgc.2018.09.004
PG 7
WC Oncology; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Urology & Nephrology
GA HI3HP
UT WOS:000456341000010
PM 30293923
DA 2025-06-11
ER

PT J
AU Lange, JN
   Mufarrij, PW
   Wood, KD
   Holmes, RP
   Assimos, DG
AF Lange, Jessica N.
   Mufarrij, Patrick W.
   Wood, Kyle D.
   Holmes, Ross P.
   Assimos, Dean G.
TI The association of cardiovascular disease and metabolic syndrome with
   nephrolithiasis
SO CURRENT OPINION IN UROLOGY
LA English
DT Review
DE hypertension; metabolic syndrome; nephrolithiasis; obesity; vascular
   disease
ID CORONARY-HEART-DISEASE; SELF-REPORTED HISTORY; KIDNEY-STONES; DIETARY
   CALCIUM; INSULIN-RESISTANCE; NATIONAL-HEALTH; BLOOD-PRESSURE;
   RISK-FACTORS; MYOCARDIAL-INFARCTION; ACID EXCRETION
AB Purpose of review
   This review describes the relationship between nephrolithiasis, vascular disease and metabolic syndrome.
   Recent findings
   There is increasing evidence that kidney stone formation is associated with a number of systemic problems including cardiovascular disease, metabolic syndrome and its components. Some of these associations are bidirectional. The reasons for these associations are not totally clear, but potential factors include metabolic responses associated with these disorders that promote a stone forming milieu in urine, environmental factors such as diet, oxidative stress and inflammation and molecular changes impacting the transport of certain analytes in urine.
   Summary
   Urologists need to be cognizant of these associations as they may be able to contribute to an early diagnosis of a significant medical problem, or provide counseling to patients to prevent their occurrence.
C1 [Assimos, Dean G.] Wake Forest Univ, Bowman Gray Sch Med, Baptist Med Ctr, Dept Urol, Winston Salem, NC 27157 USA.
C3 Wake Forest University; Wake Forest Baptist Medical Center
RP Assimos, DG (corresponding author), Wake Forest Univ, Bowman Gray Sch Med, Baptist Med Ctr, Dept Urol, Med Ctr Blvd, Winston Salem, NC 27157 USA.
EM dassimos@wakehealth.edu
RI Holmes, Ross/B-2005-2008
OI Holmes, Ross/0000-0002-8994-0159
FU National Institutes of Health [R01 DK62284]
FX This study was supported by National Institutes of Health Grant R01
   DK62284.
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NR 56
TC 28
Z9 29
U1 1
U2 8
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0963-0643
EI 1473-6586
J9 CURR OPIN UROL
JI Curr. Opin. Urol.
PD MAR
PY 2012
VL 22
IS 2
BP 154
EP 159
DI 10.1097/MOU.0b013e32834fc31f
PG 6
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 888ZI
UT WOS:000300042900013
PM 22262248
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Ilari, S
   Nucera, S
   Morabito, L
   Caminiti, R
   Mazza, V
   Ritorto, G
   Ussia, S
   Passacatini, LC
   Macrì, R
   Scarano, F
   Serra, M
   Scali, E
   Maiuolo, J
   Oppedisano, F
   Palma, E
   Muscoli, S
   Proietti, S
   Tomino, C
   Mollace, V
   Muscoli, C
AF Ilari, Sara
   Nucera, Saverio
   Morabito, Lucrezia
   Caminiti, Rosamaria
   Mazza, Valeria
   Ritorto, Giovanna
   Ussia, Sara
   Passacatini, Lucia Carmela
   Macri, Roberta
   Scarano, Federica
   Serra, Maria
   Scali, Elisabetta
   Maiuolo, Jessica
   Oppedisano, Francesca
   Palma, Ernesto
   Muscoli, Saverio
   Proietti, Stefania
   Tomino, Carlo
   Mollace, Vincenzo
   Muscoli, Carolina
TI A Systematic Review of the Effect of Polyphenols on Alterations of the
   Intestinal Microbiota and Shared Bacterial Profiles Between Metabolic
   Syndrome and Acne
SO NUTRIENTS
LA English
DT Review
DE nutraceuticals; microbiota; bacteria; metabolism; systematic review
ID GUT MICROBIOTA; OBESITY; SKIN
AB Introduction: Microbiota, composed of micro-organisms like bacteria, viruses, and non-pathogenic fungi, plays a crucial role in digestion, vitamin production, and protection against dangerous microbes. Several factors, including age, diet, alcohol consumption, stress, environmental microorganisms, and therapies (particularly antibiotics), as well as birth and nursing, could modify the microbiota. Recent research has highlighted its alteration and involvement in a various disease, including metabolic syndrome and acne. This systematic review aimed to identify common biomarkers and microbiota alterations shared between metabolic syndrome and acne, and to explore how the potential prebiotic activities of polyphenols may promote intestinal eubiosis. Materials and methods: A comprehensive search in PubMed and EMBASE resulted in 4142 articles, from which nine studies were selected based on specific criteria after removing duplicates and reviewing abstracts and full texts. All studies correlated the microbiota alteration in both pathologies and the activity of polyphenols in metabolic syndrome. Results: This review suggests that acne may be influenced by some of the same microorganisms involved in metabolic syndrome. While the literature highlights the effectiveness of polyphenols in treating metabolic syndrome, no studies have yet demonstrated their specific impact on acne. Conclusions: The research points to the potential benefits of polyphenols in modulating the microbiota, which could be relevant for individuals with metabolic syndrome. However, due to the limited data available, it was not possible to establish a direct correlation between metabolic syndrome and acne.
C1 [Ilari, Sara; Passacatini, Lucia Carmela; Tomino, Carlo] IRCCS San Raffaele Roma, I-00166 Rome, Italy.
   [Nucera, Saverio; Morabito, Lucrezia; Caminiti, Rosamaria; Mazza, Valeria; Ritorto, Giovanna; Ussia, Sara; Macri, Roberta; Scarano, Federica; Serra, Maria; Scali, Elisabetta; Maiuolo, Jessica; Oppedisano, Francesca; Palma, Ernesto; Mollace, Vincenzo; Muscoli, Carolina] Magna Graecia Univ Catanzaro, Inst Res Food Safety & Hlth IRC FSH, Dept Hlth Sci, I-88100 Catanzaro, Italy.
   [Muscoli, Saverio] Tor Vergata Univ, Dept Cardiol, I-00133 Rome, Italy.
   [Proietti, Stefania] Agea, Coordinat Body, I-00185 Rome, Italy.
C3 IRCCS San Raffaele Pisana; Magna Graecia University of Catanzaro;
   University of Rome Tor Vergata
RP Ilari, S (corresponding author), IRCCS San Raffaele Roma, I-00166 Rome, Italy.; Muscoli, C (corresponding author), Magna Graecia Univ Catanzaro, Inst Res Food Safety & Hlth IRC FSH, Dept Hlth Sci, I-88100 Catanzaro, Italy.
EM sara.ilari@sanraffaele.it; saverio.nucera@hotmail.it;
   lucreziamorabito13@gmail.com; rosamariacaminiti4@gmail.com;
   valeria.mazza001@studenti.unicz.it; giovanna.ritorto@studenti.unicz.it;
   saraussia1598@gmail.com; carmela.passacatini@sanraffaele.it;
   robertamacri85@gmail.com; federicascar87@gmail.com;
   maria.serra@studenti.unicz.it; scali@unicz.it; maiuolo@unicz.it;
   oppedisanof@libero.it; palma@unicz.it; saveriomuscoli@gmail.com;
   s.proietti@agea.gov.it; carlo.tomino@sanraffaele.it; mollace@libero.it;
   muscoli@unicz.it
RI proietti, stefania/A-9194-2019; MACRI', Roberta/AAC-5967-2022;
   Oppedisano, Francesca/GRJ-8297-2022; serra, maria/LSJ-0107-2024; ilari,
   sara/C-2628-2017; nucera, saverio/AAC-6570-2022; SCARANO,
   FEDERICA/HNC-2414-2023; Palma, ERNESTO/KRP-9299-2024; Maiuolo,
   Jessica/AAU-2482-2020; Muscoli, Carolina/G-2773-2011; Passacatini, Lucia
   Carmela/AAD-5717-2022
OI Oppedisano, Francesca/0000-0003-0930-8987; PALMA,
   Ernesto/0000-0003-4199-207X; MUSCOLI, Saverio/0000-0002-4037-7561;
   Muscoli, Carolina/0000-0002-1047-4467; serra, maria/0009-0005-7736-2207;
   nucera, saverio/0000-0002-0000-4015; mollace,
   vincenzo/0000-0002-0392-7173; MACRI', Roberta/0000-0002-2345-6751;
   Passacatini, Lucia Carmela/0000-0001-5350-1448; ilari,
   sara/0000-0002-6756-6530
FU Italian Ministry of Health; PRIN 2022 [202273HF83, P2022FAS5R]; Missione
   4 Componente 1 CUP [B83C22002820006]
FX This work was supported by the Italian Ministry of Health (grant
   SG-2021-12375551); PRIN 2022 (grant code: 202273HF83); PRIN 2022 PNRR
   (grant code: P2022FAS5R); and grant PRODIGI "Finanziato dall'Unione
   europea-Next Generation EU, Missione 4 Componente 1 CUP
   B83C22002820006". This study was also supported by the Italian Ministry
   of Health [Ricerca Corrente].
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NR 63
TC 0
Z9 0
U1 3
U2 4
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD NOV
PY 2024
VL 16
IS 21
AR 3591
DI 10.3390/nu16213591
PG 15
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA L6L9D
UT WOS:001351822800001
PM 39519424
OA gold
DA 2025-06-11
ER

PT J
AU Khodarahmi, M
   Asghari-Jafarabadi, M
   Farhangi, MA
AF Khodarahmi, Mandieh
   Asghari-Jafarabadi, Mohammad
   Farhangi, Mandieh Abbasalizad
TI A structural equation modeling approach for the association of a healthy
   eating index with metabolic syndrome and cardio-metabolic risk factors
   among obese individuals
SO PLOS ONE
LA English
DT Article
ID DIET QUALITY INDEXES; INSULIN-RESISTANCE; RELATIVE VALIDITY; DEPRESSION;
   HYPERTENSION; METAANALYSIS; ADULTS; TYPE-2; REPRODUCIBILITY;
   DETERMINANTS
AB Background
   Numerous studies have evaluated the association between dietary factors and cardiovascular risk among patients with chronic disease. It is worthwhile to assess these associations in a combination model rather than in an isolated form. In the current study, we aimed to use structural equation modeling (SEM) to assess the association of adherence to a healthy eating index (HEI)-2015 with socio-demographic factors, psychological characteristics, metabolic syndrome (MetS) and other cardio-metabolic risk factors among obese individuals.
   Methods
   This cross-sectional study was conducted among 188 healthy obese adults (96 males and 92 females) aged 20-50 years in Tabriz. A validated semi-quantitative food frequency questionnaire (FFQ) was used to record dietary intake and to estimate HEI-2015. Anthropometric parameters, blood pressure and biochemical measurements were evaluated according to standard protocols. Interrelationships among socio-demographic parameters and HEI with cardio-metabolic risk factors were analyzed using SEM.
   Results
   The results of SEM analysis revealed that HEI mediated the association between age and several cardio-metabolic risk factors including fat mass (FM), fat free mass (FFM), systolic blood pressure (SBP) and high-density lipoprotein (HDL) (p < 0.05). Moreover, adherence to Dietary Guidelines for Americans (DGA) appears to mediate association between gender and waist circumference (B = -9.78), SBP (B = -4.83), triglyceride (B = -13.01) and HDL (B = 4.31). HEI also mediated indirect negative effects of socioeconomic status on FM (B = -0.56), FFM (B = -0.25), SBP (B = -0.55) and diastolic blood pressure (DBP) (B = -0.3). Additionally, depression and age had indirect unfavorable effects on some insulin resistance indices such as homeostasis model assessment of insulin resistance (B = 0.07; p<0.05, for age) and quantitative insulin sensitivity check index (p<0.05, for age and depression) via HEI. High adherence to HEI was found to be inversely associated with MetS risk (p<0.05).
   Conclusion
   Adherence to HEI-2015 seems to mediate the effect of socio-demographic parameters and mental health on cardio-metabolic risk factors as well as MetS risk. Further studies are needed to confirm these findings.
C1 [Khodarahmi, Mandieh] Tabriz Univ Med Sci, Fac Nutr & Food Sci, Nutr Res Ctr, Dept Community Nutr, Tabriz, Iran.
   [Khodarahmi, Mandieh] Tabriz Univ Med Sci, Fac Nutr & Food Sci, Dept Nutr, Student Res Comm, Tabriz, Iran.
   [Asghari-Jafarabadi, Mohammad] Tabriz Univ Med Sci, Rd Traff Injury Res Ctr, Tabriz, Iran.
   [Asghari-Jafarabadi, Mohammad] Tabriz Univ Med Sci, Fac Hlth, Dept Stat & Epidemiol, Tabriz, Iran.
   [Farhangi, Mandieh Abbasalizad] Tabriz Univ Med Sci, Drug Appl Res Ctr, Tabriz, Iran.
C3 Tabriz University of Medical Science; Tabriz University of Medical
   Science; Tabriz University of Medical Science; Tabriz University of
   Medical Science; Tabriz University of Medical Science
RP Farhangi, MA (corresponding author), Tabriz Univ Med Sci, Drug Appl Res Ctr, Tabriz, Iran.
EM Abbasalizad_m@yahoo.corn
RI Farhangi, Mahdieh/AAC-6758-2019; Asghari Jafarabadi,
   Mohammmad/A-7478-2017
OI Asghari Jafarabadi, Mohammmad/0000-0003-3284-9749; Abbasalizad Farhangi,
   Mahdieh/0000-0002-7036-6900
FU Research Undersecretary of Tabriz University of Medical Sciences
   [IR.TBZMED.REC.1396.768]
FX The current work has been granted by Research Undersecretary of Tabriz
   University of Medical Sciences (Grant No. IR.TBZMED.REC.1396.768) as a
   Ph.D. thesis of MKH.
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NR 65
TC 54
Z9 59
U1 0
U2 6
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JUL 1
PY 2019
VL 14
IS 7
AR e0219193
DI 10.1371/journal.pone.0219193
PG 20
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Science & Technology - Other Topics
GA IW3YW
UT WOS:000484918700042
PM 31260504
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Veurink, G
   Perry, G
   Singh, SK
AF Veurink, Gerald
   Perry, George
   Singh, Sandeep Kumar
TI Role of antioxidants and a nutrient rich diet in Alzheimer's disease
SO OPEN BIOLOGY
LA English
DT Review
DE Alzheimer's disease; antioxidant; oxidative stress; neuroprotection;
   nutrient; nutraceutical
ID INSULIN-RESISTANCE SYNDROME; LIPID PEROXIDE FORMATION; ACID-BASE
   COMPOSITION; AMYLOID BETA-PROTEIN; OXIDATIVE STRESS; A-BETA; ASCORBYL
   PALMITATE; MOLECULAR-HYDROGEN; VASCULAR DEMENTIA; CONTROLLED-TRIAL
AB The joint attack on the body by metabolic acidosis and oxidative stress suggests that treatment in degenerative diseases, including Alzheimer's disease (AD), may require a normalizing of extracellular and intracellular pH with simultaneous supplementation of an antioxidant combination cocktail at a sufficiently high dose. Evidence is also accumulating that combinations of antioxidants may be more effective, taking advantage of synergistic effects of appropriate antioxidants as well as a nutrient-rich diet to prevent and reverse AD. This review focuses on nutritional, nutraceutical and antioxidant treatments of AD, although they can also be used in other chronic degenerative and neurodegenerative diseases.
C1 [Veurink, Gerald] Naturels, Armadale, WA, Australia.
   [Veurink, Gerald] Univ Western Australia, Dept Surg, Perth, WA, Australia.
   [Veurink, Gerald; Singh, Sandeep Kumar] Indian Sci Educ & Technol Fdn, Lucknow 226002, Uttar Pradesh, India.
   [Perry, George] Univ Texas San Antonio, Dept Biol, San Antonio, TX USA.
   [Singh, Sandeep Kumar] Ctr Biomed Res, SGPGI Campus, Lucknow 226014, Uttar Pradesh, India.
C3 University of Western Australia; University of Texas System; University
   of Texas at San Antonio (UTSA); Sanjay Gandhi Postgraduate Institute of
   Medical Sciences
RP Singh, SK (corresponding author), Indian Sci Educ & Technol Fdn, Lucknow 226002, Uttar Pradesh, India.; Singh, SK (corresponding author), Ctr Biomed Res, SGPGI Campus, Lucknow 226014, Uttar Pradesh, India.
EM sks.1247@gmail.com
RI Singh, Dr. Sandeep/D-6544-2013; Perry, George/A-8611-2009
OI Perry, George/0000-0002-6547-0172; Singh, Sandeep
   Kumar/0000-0002-0022-6240
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NR 191
TC 50
Z9 56
U1 3
U2 36
PU ROYAL SOC
PI LONDON
PA 6-9 CARLTON HOUSE TERRACE, LONDON SW1Y 5AG, ENGLAND
EI 2046-2441
J9 OPEN BIOL
JI Open Biol
PD JUN 17
PY 2020
VL 10
IS 6
AR 200084
DI 10.1098/rsob.200084
PG 16
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA MB7SP
UT WOS:000542799500001
PM 32543351
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Ikram, UZ
   Snijder, MB
   Agyemang, C
   Schene, AH
   Peters, RJG
   Stronks, K
   Kunst, AE
AF Ikram, Umar Z.
   Snijder, Marieke B.
   Agyemang, Charles
   Schene, Aart H.
   Peters, Ron J. G.
   Stronks, Karien
   Kunst, Anton E.
TI Perceived Ethnic Discrimination and the Metabolic Syndrome in Ethnic
   Minority Groups: The Healthy Life in an Urban Setting Study
SO PSYCHOSOMATIC MEDICINE
LA English
DT Article
DE discrimination; metabolic syndrome; ethnic minority groups; ethnic
   inequalities; social epidemiology; Europe; HELIUS study
ID SELF-REPORTED EXPERIENCES; AFRICAN-AMERICAN WOMEN; EVERYDAY
   DISCRIMINATION; RACIAL-DISCRIMINATION; ALLOSTATIC LOAD; HEART-DISEASE;
   RISK; STRESS; ADULTS; CALCIFICATION
AB Objective: Ethnic differences in the metabolic syndrome could be explained by perceived ethnic discrimination (PED). It is unclear whether PED is associated with the metabolic syndrome. We assessed this association and quantified the contribution of PED to the metabolic syndrome.
   Methods: Baseline data were used from the Healthy Life in an Urban Setting study collected in the Netherlands from 2011 to 2014. The population-based sample included South-Asian Surinamese, African Surinamese, Ghanaian, Turkish, and Moroccan participants (aged 18 to 70 years). PED was measured using the Everyday Discrimination Scale. The metabolic syndrome was determined according to the harmonized definition of the International Diabetes Federation, American Heart Association, and others. Logistic regression was used for analysis. population-attributable fraction was used to calculate the contribution of PED.
   Results: PED was positively associated with the metabolic syndrome in South-Asian Surinamese, African Surinamese, and Moroccan participants (odds ratio [95% confidence interval] = 1.13 [0.99-1.30], 1.15 [1.00-1.32], and 1.19 [1.03-1.38], respectively) after adjusting for potential confounders and mediators. No significant association was observed among Ghanaian and Turkish participants. For the individual components, the associations were statistically significant for blood pressure, fasting glucose, and waist circumference among Surinamese participants. PED was associated with dyslipidemia in Moroccan participants. The population-attributable fractions were 5% for South-Asian Surinamese and Moroccan participants, and 7% for African Surinamese participants.
   Conclusions: We found a positive association of PED with the metabolic syndrome in some ethnic groups, with PED contributing around 5% to 7% to the metabolic syndrome among Surinamese and Moroccans. This suggests that PED might contribute to ethnic differences in the metabolic syndrome.
C1 [Ikram, Umar Z.; Snijder, Marieke B.; Agyemang, Charles; Stronks, Karien; Kunst, Anton E.] Univ Amsterdam, Acad Med Ctr, Dept Publ Hlth, Meibergdreef 15, NL-1105 AZ Amsterdam, Netherlands.
   [Peters, Ron J. G.] Univ Amsterdam, Acad Med Ctr, Dept Cardiol, Meibergdreef 15, NL-1105 AZ Amsterdam, Netherlands.
   [Schene, Aart H.] Radboud Univ Nijmegen, Med Ctr, Dept Psychiat, Nijmegen, Netherlands.
   [Schene, Aart H.] Radboud Univ Nijmegen, Donders Inst Brain Cognit & Behaviour, Nijmegen, Netherlands.
C3 University of Amsterdam; University of Amsterdam; Radboud University
   Nijmegen; Radboud University Nijmegen
RP Ikram, UZ (corresponding author), Univ Amsterdam, Acad Med Ctr, Dept Publ Hlth, Meibergdreef 15, NL-1105 AZ Amsterdam, Netherlands.
EM u.ikram@amc.uva.nl
RI Schene, A.H./H-8085-2014; Kunst, Anton/M-3021-2014; Sonestedt,
   Emily/I-3814-2016
OI Stronks, Karien/0000-0002-0921-2232; Kunst, Anton/0000-0002-3313-5273
FU Dutch Heart Foundation [2010 T084]; Netherlands Organization for Health
   Research and Development [200500003, 40-00812-98-11020]; European Union
   [278901]
FX The Academic Medical Center Amsterdam and the Public Health Service of
   Amsterdam provided core support for the HELIUS study. The HELIUS study
   is additionally funded by the Dutch Heart Foundation (Grant No. 2010
   T084), the Netherlands Organization for Health Research and Development
   (Grant No. 200500003), and the European Union (Grant No. 278901). The
   first author was supported by a grant from the Netherlands Organization
   for Health Research and Development (Grant No. 40-00812-98-11020). The
   authors declared no conflicts of interest.
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NR 63
TC 27
Z9 29
U1 0
U2 13
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0033-3174
EI 1534-7796
J9 PSYCHOSOM MED
JI Psychosom. Med.
PD JAN
PY 2017
VL 79
IS 1
BP 101
EP 111
DI 10.1097/PSY.0000000000000350
PG 11
WC Psychiatry; Psychology; Psychology, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry; Psychology
GA EI3RM
UT WOS:000392409000011
PM 27359175
DA 2025-06-11
ER

PT J
AU Ferro, FED
   Lima, VBD
   Soares, NRM
   Almondes, KGD
   Pires, LV
   Cozzolino, SMF
   Marreiro, DD
AF Dourado Ferro, Flavia Ennes
   de Sousa Lima, Vanessa Batista
   Mello Soares, Nina Rosa
   de Sousa Almondes, Kaluce Goncalves
   Pires, Liliane Viana
   Franciscato Cozzolino, Silvia Maria
   Marreiro, Dilina do Nascimento
TI Parameters of Metabolic Syndrome and Its Relationship with Zincemia and
   Activities of Superoxide Dismutase and Glutathione Peroxidase in Obese
   Women
SO BIOLOGICAL TRACE ELEMENT RESEARCH
LA English
DT Article
DE Obesity; Zinc; Superoxide dismutase; Glutathione peroxidase; Metabolic
   syndrome
ID OXIDATIVE STRESS; PLASMA
AB Alterations in antioxidant defense in obese people with metabolic syndrome can contribute to oxidative stress. This study assessed the relationship between the parameters of metabolic syndrome and the zincemia, activity of superoxide dismutase, and glutathione peroxidase enzymes in obese women. Seventy-three premenopausal women, aged between 20 and 50 years, were divided into two groups: case group, composed of obese (n = 37), and control group, composed of no obese (n = 36). Analyses of zinc intake, parameters of metabolic syndrome, plasma, and erythrocyte zinc, and activities of superoxide dismutase and glutathione peroxidase were carried out. The mean values of body mass index of obese women and control group were 34.5 +/- 3.4 and 21.7 +/- 1.9 kg/m(2), respectively (p < 0.05). In the study, body mass index, waist circumference, and zinc intake were higher in obese women than control group (p < 0.05). The plasma zinc and activity of superoxide dismutase did not show significant differences between obese and controls (p > 0.05). The values of erythrocyte zinc was 36.4 +/- 15.0 mu g/gHb and 45.4 +/- 14.3 mu g/gHb and of glutathione peroxidase was 46.4 +/- 19.4 U/gHb and 36.7 +/- 13.6 U/gHb in obese women and controls, respectively (p < 0.05). The study shows that there are alterations in biochemical parameters of zinc in obese women, with low zinc concentrations in erythrocytes. Regression analysis demonstrates that the erythrocyte zinc and activity of superoxide dismutase enzyme is influenced by components of the metabolic syndrome, and the plasmatic glucose, body mass index, and waist circumference have a negative correlation with this enzyme.
C1 [Dourado Ferro, Flavia Ennes; de Sousa Lima, Vanessa Batista; Mello Soares, Nina Rosa; Marreiro, Dilina do Nascimento] Univ Fed Piaui UFPI, Dept Nutr, BR-64048320 Teresina, PI, Brazil.
   [de Sousa Almondes, Kaluce Goncalves; Pires, Liliane Viana; Franciscato Cozzolino, Silvia Maria] Univ Sao Paulo, Dept Sci Food & Expt Nutr, Sch Pharm, Sao Paulo, Brazil.
C3 Universidade Federal do Piaui; Universidade de Sao Paulo
RP Marreiro, DD (corresponding author), Univ Fed Piaui UFPI, Dept Nutr, Rua Hugo Napoleao 665 Ed Palazzo Reale Apt 2001 J, BR-64048320 Teresina, PI, Brazil.
EM dilina.marreiro@gmail.com
RI Cozzolino, Silvia/K-7623-2016
OI Cozzolino, Silvia/0000-0003-1505-7627; PIRES,
   LILIANE/0000-0003-1710-0836; Almondes, Kaluce/0000-0003-2694-1629;
   ENNES, FLAVIA/0000-0002-1686-0254
CR [Anonymous], 2000, WHO TECH REP SER, V894, pi
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NR 18
TC 20
Z9 20
U1 0
U2 2
PU HUMANA PRESS INC
PI TOTOWA
PA 999 RIVERVIEW DRIVE SUITE 208, TOTOWA, NJ 07512 USA
SN 0163-4984
EI 1559-0720
J9 BIOL TRACE ELEM RES
JI Biol. Trace Elem. Res.
PD NOV
PY 2011
VL 143
IS 2
BP 787
EP 793
DI 10.1007/s12011-010-8940-6
PG 7
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 829UH
UT WOS:000295609300018
PM 21210247
DA 2025-06-11
ER

PT J
AU Hutcheson, R
   Terry, R
   Hutcheson, B
   Jadhav, R
   Chaplin, J
   Smith, E
   Barrington, R
   Proctor, SD
   Rocic, P
AF Hutcheson, Rebecca
   Terry, Russell
   Hutcheson, Brenda
   Jadhav, Rashmi
   Chaplin, Jennifer
   Smith, Erika
   Barrington, Robert
   Proctor, Spencer D.
   Rocic, Petra
TI miR-21-mediated decreased neutrophil apoptosis is a determinant of
   impaired coronary collateral growth in metabolic syndrome
SO AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
LA English
DT Article
DE apoptosis; collateral circulation; inflammation; microRNA; metabolic
   syndrome
ID ANGIOTENSIN-II; NITRIC-OXIDE; INFLAMMATION; RESTORATION; ACTIVATION;
   PYK2; RAT; AKT
AB Coronary collateral growth (CCG) is impaired in metabolic syndrome. microRNA-21 (miR-21) is a proproliferative and antiapoptotic miR, which we showed to be elevated in metabolic syndrome. Here we investigate whether impaired CCG in metabolic syndrome involved miR-21-mediated aberrant apoptosis. Normal Sprague-Dawley (SD) and metabolic syndrome [J. C. Russel (JCR)] rats underwent transient, repetitive coronary artery occlusion [repetitive ischemia (RI)]. Antiapoptotic Bcl-2, phospho-Bad, and Bcl-2/Bax dimers were increased on days 6 and 9 RI, and proapoptotic Bax and Bax/Bax dimers and cytochrome-c release concurrently decreased in JCR versus SD rats. Active caspases were decreased in JCR versus SD rats (similar to 50%). Neutrophils increased transiently on day 3 RI in the collateral-dependent zone of SD rats but remained elevated in JCR rats, paralleling miR-21 expression. miR-21 downregulation by anti-miR-21 induced neutrophil apoptosis and decreased Bcl-2 and Bcl-2/Bax dimers (similar to 75%) while increasing Bax/Bax dimers, cytochrome-c release, and caspase activation (similar to 70, 400, and 400%). Anti-miR-21 also improved CCG in JCR rats (similar to 60%). Preventing neutrophil infiltration with blocking antibodies resulted in equivalent CCG recovery, confirming a major role for deregulated neutrophil apoptosis in CCG impairment. Neutrophil and miR-21-dependent CCG inhibition was in significant part mediated by increased oxidative stress. We conclude that neutrophil apoptosis is integral to normal CCG and that inappropriate prolonged miR-21-mediated survival of neutrophils plays a major role in impaired CCG, in part via oxidative stress generation.
C1 [Hutcheson, Rebecca; Hutcheson, Brenda; Rocic, Petra] New York Med Coll, Dept Pharmacol, Valhalla, NY 10595 USA.
   [Terry, Russell; Jadhav, Rashmi; Chaplin, Jennifer; Smith, Erika] Univ S Alabama, Coll Med, Dept Biochem & Mol Biol, Mobile, AL USA.
   [Barrington, Robert] Univ S Alabama, Coll Med, Dept Microbiol & Immunol, Mobile, AL 36688 USA.
   [Proctor, Spencer D.] Univ Alberta, Alberta Inst Human Nutr, Metab & Cardiovasc Dis Lab, Edmonton, AB, Canada.
C3 New York Medical College; University of South Alabama; University of
   South Alabama; University of Alberta
RP Rocic, P (corresponding author), New York Med Coll, Dept Pharmacol, 15 Dana Rd,BSB 502, Valhalla, NY 10595 USA.
EM petra_rocic@nymc.edu
RI JADHAV, RASHMI/GQI-2890-2022; Proctor, Spencer/F-2774-2012; Barrington,
   Robert/IRZ-8912-2023; Terry, Russell/X-8364-2019
OI Rocic, Petra/0000-0002-5781-3075; Terry, Russell/0000-0002-3659-060X;
   Barrington, Robert/0000-0001-5713-5369; Proctor,
   Spencer/0000-0002-7597-5262
FU National Heart, Lung, and Blood Institute [R01-HL-093052]
FX This work was supported by National Heart, Lung, and Blood Institute
   Grant R01-HL-093052.
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NR 31
TC 14
Z9 17
U1 0
U2 2
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0363-6135
EI 1522-1539
J9 AM J PHYSIOL-HEART C
JI Am. J. Physiol.-Heart Circul. Physiol.
PD JUN 1
PY 2015
VL 308
IS 11
BP H1323
EP H1335
DI 10.1152/ajpheart.00654.2014
PG 13
WC Cardiac & Cardiovascular Systems; Physiology; Peripheral Vascular
   Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Physiology
GA CK5MS
UT WOS:000356269600003
PM 25840830
OA Green Published
DA 2025-06-11
ER

PT J
AU Singh, H
   Ganneru, S
   Malakapalli, V
   Chalasani, M
   Nappanveettil, G
   Bhonde, RR
   Venkatesan, V
AF Singh, Himadri
   Ganneru, Sireesha
   Malakapalli, Venkata
   Chalasani, Maniprabha
   Nappanveettil, Giridharan
   Bhonde, Ramesh R.
   Venkatesan, Vijayalakshmi
TI Islet adaptation to obesity and insulin resistance in WNIN/GR-Ob rats
SO ISLETS
LA English
DT Article
DE islets; insulin resistance; hyperinsulinemia; hypertrophy; WNIN/GR-Ob
   mutant rats
ID NECROSIS-FACTOR-ALPHA; PANCREATIC BETA-CELL; GENE-EXPRESSION; METABOLIC
   SYNDROME; ANIMAL-MODELS; TNF-ALPHA; INFLAMMATION; GLUCOSE; MICE;
   SECRETION
AB WNIN/GR-Ob mutant rat is a novel animal model to study metabolic syndrome (obesity, insulin resistance, hyperinsulinemia, impaired glucose tolerance and cardiovascular diseases). We have investigated the islet characteristics of obese mutants at different age groups (1, 6 and 12 months) to assess the islet changes in response to early and chronic metabolic stress. Our data demonstrates altered islet cell morphology and function (hypertrophy, fibrotic lesions, vacuolation, decreased stimulation index, increased TNF alpha, ROS and TBARS levels) in mutants as compared to controls. Furthermore, network analysis (gene-gene interaction) studied in pancreas demonstrated increased inflammation as a key factor underlying obesity/metabolic syndrome in mutants. These observations pave way to explore this model to understand islet adaptation in response to metabolic syndrome.
C1 [Singh, Himadri; Ganneru, Sireesha; Malakapalli, Venkata; Chalasani, Maniprabha; Venkatesan, Vijayalakshmi] Indian Council Med Res, Natl Inst Nutr, Biochem Stem Cell Res, Hyderabad 500007, Andhra Pradesh, India.
   [Nappanveettil, Giridharan] Natl Inst Nutr, Natl Ctr Lab Anim Sci, Hyderabad 500007, Andhra Pradesh, India.
   [Bhonde, Ramesh R.] Manipal Univ, Sch Regenerat Med, Bangalore, Karnataka, India.
C3 Indian Council of Medical Research (ICMR); ICMR - National Institute of
   Nutrition (NIN); Indian Council of Medical Research (ICMR); ICMR -
   National Institute of Nutrition (NIN); ICMR - National Animal Resource
   Facility for Biomedical Research (NARFBR); Manipal Academy of Higher
   Education (MAHE)
RP Venkatesan, V (corresponding author), Indian Council Med Res, Natl Inst Nutr, Biochem Stem Cell Res, Jamai Osmania Po, Hyderabad 500007, Andhra Pradesh, India.
EM v.venkateshan@gmail.com
RI BHONDE, RAMESH/C-1233-2009; Singh, Himadri/G-1023-2012
OI Venkatesan, Vijayalakhsmi/0000-0002-3142-9657; Singh,
   Himadri/0000-0002-2354-6474
FU ICMR Junior Research Fellowship [Three/1/3/JRF-2009/MPD]
FX First author is a recipient of ICMR Junior Research Fellowship (letter
   no. Three/1/3/JRF-2009/MPD Dated 27.11.2009).
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NR 67
TC 18
Z9 19
U1 0
U2 3
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1938-2014
EI 1938-2022
J9 ISLETS
JI Islets
PY 2014
VL 6
IS 5-6
AR e998099
DI 10.1080/19382014.2014.998099
PG 13
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA CF5TA
UT WOS:000352618700002
PM 25833252
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Maury, E
   Brichard, SM
AF Maury, E.
   Brichard, S. M.
TI Adipokine dysregulation, adipose tissue inflammation and metabolic
   syndrome
SO MOLECULAR AND CELLULAR ENDOCRINOLOGY
LA English
DT Review
DE Adipokines; Metabolic syndrome; Adipose tissue; Obesity; Inflammation;
   Adipocytes
ID NECROSIS-FACTOR-ALPHA; MONOCYTE CHEMOATTRACTANT PROTEIN-1;
   PLASMINOGEN-ACTIVATOR INHIBITOR-1; DIET-INDUCED OBESITY; FACTOR-KAPPA-B;
   INTERNATIONAL-DIABETES-FEDERATION; ENDOTHELIAL ADHESION MOLECULES;
   ENDOPLASMIC-RETICULUM STRESS; INDUCED INSULIN-RESISTANCE;
   RENIN-ANGIOTENSIN SYSTEM
AB Obesity plays a causative role in the pathogenesis of the metabolic syndrome. Adipokines may link obesity to its co-morbidities. Most adipokines with pro-inflammatory properties are overproduced with increasing adiposity, while some adipokines with anti-inflammatory or insulin-sensitizing properties, like adiponectin are decreased. This dysregulation of adipokine production may promote obesity-linked metabolic disorders and cardiovascular disease. Besides considering adipokines, this review will also highlight the cellular key players and molecular mechanisms involved in adipose inflammation. Targeting the changes in the cellular composition of adipose tissue, the underlying molecular mechanisms, and the altered production of adipokines may have therapeutic potential in the management of the metabolic syndrome. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
C1 [Maury, E.; Brichard, S. M.] Univ Louvain, Fac Med, Endocrinol & Metab Unit, B-1200 Brussels, Belgium.
C3 Universite Catholique Louvain
RP Brichard, SM (corresponding author), Catholic Univ Louvain, Unite Endocrinol & Metab, ENDO 5530, Av Hippocrate 55, B-1200 Brussels, Belgium.
EM Eleonore.Maury@uclouvain.be; sonia.brichard@uclouvain.be
RI Brichard, Sonia/B-4597-2013
OI Maury, Eleonore/0000-0001-7517-1988
FU Foundation of Scientific and Medical Research; General Division of
   Scientific Research (Belgium)
FX Our work was supported by grants from the Foundation of Scientific and
   Medical Research and from the General Division of Scientific Research
   (Belgium).
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   Zeyda M, 2007, INT J OBESITY, V31, P1420, DOI 10.1038/sj.ijo.0803632
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NR 230
TC 811
Z9 920
U1 4
U2 178
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0303-7207
EI 1872-8057
J9 MOL CELL ENDOCRINOL
JI Mol. Cell. Endocrinol.
PD JAN 15
PY 2010
VL 314
IS 1
BP 1
EP 16
DI 10.1016/j.mce.2009.07.031
PG 16
WC Cell Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Endocrinology & Metabolism
GA 523VC
UT WOS:000272101700001
PM 19682539
DA 2025-06-11
ER

PT J
AU Lee, YJ
   Seo, JA
   Yoon, T
   Seo, I
   Lee, JH
   Im, D
   Lee, JH
   Bahn, KN
   Ham, HS
   Jeong, SA
   Kang, TS
   Ahn, JH
   Kim, DH
   Nam, GE
   Kim, NH
AF Lee, Y. J.
   Seo, J. A.
   Yoon, T.
   Seo, I.
   Lee, J. H.
   Im, D.
   Lee, J. H.
   Bahn, K-N.
   Ham, H. S.
   Jeong, S. A.
   Kang, T. S.
   Ahn, J. H.
   Kim, D. H.
   Nam, G. E.
   Kim, N. H.
TI Effects of low-fat milk consumption on metabolic and atherogenic
   biomarkers in Korean adults with the metabolic syndrome: a randomised
   controlled trial
SO JOURNAL OF HUMAN NUTRITION AND DIETETICS
LA English
DT Article
DE anthropometry; cardiovascular disease; dietary intervention
ID C-REACTIVE PROTEIN; DAIRY PRODUCT CONSUMPTION; ENDOTHELIAL DYSFUNCTION;
   INFLAMMATORY STRESS; HEART-DISEASE; MARKERS; ASSOCIATION; CALCIUM;
   OBESITY; HEALTH
AB BackgroundPrevious studies of the health effects of low-fat milk or dairy consumption on the metabolic syndrome have yielded inconsistent results. The present study aimed to investigate the effects of low-fat milk consumption on traits associated with the metabolic syndrome, as well as inflammatory and atherogenic biomarkers, in Korean adults with the metabolic syndrome.
   MethodsOverweight Koreans with the metabolic syndrome (n = 58) were recruited and randomly assigned to either the low-fat milk or control group. The low-fat milk group was instructed to consume two packs of low-fat milk per day (200 mL twice daily) for 6 weeks, and the control group was instructed to maintain their habitual diet. Clinical investigations were conducted during the screening visit, on study day 0, and after 6 weeks.
   ResultsNo significant differences in changes in body mass index, blood pressure, lipid profile and adiponectin levels, as well as levels of inflammatory markers, oxidative stress markers and atherogenic markers, were found between the low-fat milk and control groups. However, compared to the controls, significant favourable decreases in serum soluble vascular adhesion molecule-1 and endothelin-1 levels were found in the 12 subjects with high blood pressure and in the 18 subjects with hypertriglyceridaemia in the low-fat milk group.
   ConclusionsThe present study did not demonstrate an overall beneficial effect of low-fat milk consumption in subjects with the metabolic syndrome. However, low-fat milk consumption may have a favourable effect on atherogenic markers in subjects with high blood pressure or hypertriglyceridaemia.
C1 [Lee, Y. J.; Yoon, T.; Seo, I.; Lee, J. H.; Im, D.; Lee, J. H.; Bahn, K-N.; Ham, H. S.; Jeong, S. A.; Kang, T. S.] Natl Inst Food & Drug Safety Evaluat, Nutr & Funct Food Res Team, Chungcheongbuk Do, South Korea.
   [Seo, J. A.; Ahn, J. H.; Kim, N. H.] Korea Univ, Coll Med, Ansan Hosp, Dept Endocrinol Diabet & Metab, 516 Gojan Dong, Ansan 425707, Gyeonggi Do, South Korea.
   [Kim, D. H.; Nam, G. E.] Korea Univ, Coll Med, Ansan Hosp, Dept Family Med, 516 Gojan Dong, Ansan 425707, Gyeonggi Do, South Korea.
C3 Ministry of Food & Drug Safety (MFDS), Republic of Korea; National
   Institute of Food & Drug Safety Evaluation; Korea University; Korea
   University Medicine (KU Medicine); Korea University; Korea University
   Medicine (KU Medicine)
RP Kim, NH (corresponding author), Korea Univ, Coll Med, Ansan Hosp, Dept Endocrinol Diabet & Metab, 516 Gojan Dong, Ansan 425707, Gyeonggi Do, South Korea.; Kim, DH (corresponding author), Korea Univ, Coll Med, Ansan Hosp, Dept Family Med, 516 Gojan Dong, Ansan 425707, Gyeonggi Do, South Korea.
EM kmcfm@hanmail.net; nhkendo@gmail.com
RI Nam, Ga Eun/AAU-6055-2020; Lee, JongGu/B-7384-2013; Kim, Nan/T-8627-2019
OI Kim, Do Hoon/0000-0001-7421-4501; Kim, Nan Hee/0000-0003-4378-520X; Nam,
   Ga Eun/0000-0002-6739-9904
FU Ministry of Food and Drug Safety [12161MFDS118]
FX This research was supported by a grant (12161MFDS118) from Ministry of
   Food and Drug Safety in 2012.
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Z9 18
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PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0952-3871
EI 1365-277X
J9 J HUM NUTR DIET
JI J. Hum. Nutr. Diet.
PD AUG
PY 2016
VL 29
IS 4
BP 477
EP 486
DI 10.1111/jhn.12349
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA DR6OE
UT WOS:000380020400010
PM 26945812
DA 2025-06-11
ER

PT J
AU Sarrafzadegan, N
   Kelishadi, R
   Sadri, G
   Malekafzali, H
   Pourmoghaddas, M
   Heidari, K
   Shirani, S
   Bahonar, A
   Boshtam, M
   Asgary, S
   Mohammadifard, N
   Sadeghi, M
   Eshrati, B
   Hadipour, E
   Esmaillzadeh, A
   O'Loughlin, JL
AF Sarrafzadegan, Nizal
   Kelishadi, Roya
   Sadri, Gholamhossein
   Malekafzali, Hossein
   Pourmoghaddas, Masoud
   Heidari, Kamal
   Shirani, Shahin
   Bahonar, Ahmad
   Boshtam, Maryam
   Asgary, Sedigheh
   Mohammadifard, Noushin
   Sadeghi, Masoumeh
   Eshrati, Babak
   Hadipour, Ebrahim
   Esmaillzadeh, Ahmad
   O'Loughlin, Jennifer L.
TI Outcomes of a Comprehensive Healthy Lifestyle Program on Cardiometabolic
   Risk Factors in a Developing Country: The Isfahan Healthy Heart Program
SO ARCHIVES OF IRANIAN MEDICINE
LA English
DT Article
DE Cardiovascular risk factors; community-based intervention; developing
   country; non-communicable disease
ID CARDIOVASCULAR-DISEASE PREVENTION; COMMUNITY-BASED PROGRAM;
   NONCOMMUNICABLE DISEASES; INTERVENTION PROGRAM; METABOLIC SYNDROME;
   PREVALENCE; EDUCATION; NUTRITION; MORTALITY; BURDEN
AB Background: This study evaluated the outcome of a comprehensive, community-based healthy lifestyle program on cardionnetabolic risk factors. The Isfahan Healthy Heart Program (IHHP) was a comprehensive action-oriented, multi-component intervention with a quasi-experimental design and reference area.
   Methods: IHHP targeted the population-at-large (n = 2,180,000) in three districts in central Iran. Data from independent sample surveys before (2000 - 2001) and after (2007) this program were used to compare differences in the intervention area and reference area over time after controlling for age, education level and income. The samples in 2000 - 2001 and 2007 included 6175 and 4719 participants in intervention area, and 6339 and 4853 in reference area, respectively. Multiple interventional activities were performed based on the four main strategies of healthy nutrition, increased physical activity, tobacco control and coping with stress.
   Results: The prevalence of abdominal obesity, hypertension, hypercholesterolemia, hypertriglyceridemia and high LDL-C decreased significantly in the intervention area versus the reference area in both sexes. However the reduction in overweight and obesity was significant only in females (P < 0.05 for all). There were no significant changes in the prevalence of diabetes mellitus.
   In the intervention area, the prevalence of hypercholesterolemia decreased from 23.5% to 12.5% among females without any changes in females in the reference area (p < 0.0001). In males, hypercholesterolemia decreased significantly in both intervention area (18.5% to 9.6%) and reference area (14.4% to 9.8%; p = 0.005). Mean triglyceride levels had a significant decrease in the intervention area and a non-significant decrease in the reference area (p < 0.0001).
   Conclusions: A comprehensive healthy lifestyle program comprising preventive and promotional activities that considers both population and high risk approaches can be effective in controlling cardiometabolic risk factors in a middle-income country.
C1 [Sarrafzadegan, Nizal; Kelishadi, Roya; Shirani, Shahin; Boshtam, Maryam; Mohammadifard, Noushin] Isfahan Univ Med Sci, Isfahan Cardiovasc Res Inst, Cardiovasc Res Ctr, Esfahan, Iran.
   [Sadri, Gholamhossein; Pourmoghaddas, Masoud] Isfahan Univ Med Sci, Fac Med, Esfahan, Iran.
   [Malekafzali, Hossein] Univ Tehran Med Sci, Sch Publ Hlth, Dept Biostat & Epidemiol, Tehran, Iran.
   [Heidari, Kamal] Isfahan Univ Med Sci, Isfahan Provincal Hlth Ctr, Esfahan, Iran.
   [Bahonar, Ahmad] Isfahan Univ Med Sci, Isfahan Cardiovasc Res Inst, Hypertens Res Ctr, Esfahan, Iran.
   [Asgary, Sedigheh] Isfahan Univ Med Sci, Isfahan Cardiovasc Res Inst, Physiol Res Ctr, Esfahan, Iran.
   [Sadeghi, Masoumeh] Isfahan Univ Med Sci, Cardiac Rehabil Res Ctr, Esfahan, Iran.
   [Eshrati, Babak] Arak Univ Med Sci, Arak, Iran.
   [Hadipour, Ebrahim] Isfahan Univ Med Sci, Najafabad Hlth Ctr, Esfahan, Iran.
   [Esmaillzadeh, Ahmad] Isfahan Univ Med Sci, Sch Nutr & Food Sci, Dept Community Nutr, Food Secur Res Ctr, Esfahan, Iran.
   [O'Loughlin, Jennifer L.] Univ Montreal, Dept Social Med, Montreal, PQ, Canada.
C3 Isfahan University of Medical Sciences; Isfahan University of Medical
   Sciences; Tehran University of Medical Sciences; Isfahan University of
   Medical Sciences; Isfahan University of Medical Sciences; Isfahan
   University of Medical Sciences; Isfahan University of Medical Sciences;
   Isfahan University of Medical Sciences; Isfahan University of Medical
   Sciences; Universite de Montreal
RP Sarrafzadegan, N (corresponding author), Isfahan Univ Med Sci, Isfahan Cardiovasc Res Inst, WHO Collaborating Ctr EMR, Cardiovasc Res Ctr, POB 81465-1148, Esfahan, Iran.
EM nsarrafzadegan@gmail.com
RI Boshtam, Maryam/W-7910-2019; Sadeghi, Masoumeh/W-2291-2017;
   Mohammadifard, Noushin/M-2244-2018; Bahonar, Ahmad/Q-7698-2019;
   Kelishadi, Roya/E-6154-2012; Esmaillzadeh, Ahmad/N-5704-2014;
   pourmoghadas, masoud/B-7441-2018; Sarrafzadegan, Nizal/V-5826-2017
OI Sadeghi Mahonak, Masoumeh/0000-0001-7179-5558; Kelishadi,
   Roya/0000-0001-7455-1495; heidari, kamal/0000-0002-6678-0244;
   Esmaillzadeh, Ahmad/0000-0002-8735-6047; pourmoghadas,
   masoud/0000-0003-2469-7853; Sarrafzadegan, Nizal/0000-0002-8352-0540
FU Iranian Budget and Planning Organization [31309304]; Deputy for Health
   from the Iranian Ministry of Health and Medical Education; Iranian Heart
   Foundation
FX This program was conducted by the Isfahan Cardiovascular Research Center
   (ICRC), a WHO Collaborating Center with the collaboration of the Isfahan
   Provincial Health Office, both of which are affiliated with the Isfahan
   University of Medical Sciences. The program was supported by a grant
   (No. 31309304) from the Iranian Budget and Planning Organization, as
   well as the Deputy for Health from the Iranian Ministry of Health and
   Medical Education, and the Iranian Heart Foundation. We are thankful to
   the team of ICRC and Isfahan Provincial Health Office as well as
   collaborators from both the Najaf-Abad Health Office and Arak University
   of Medical Sciences.
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NR 32
TC 55
Z9 55
U1 0
U2 9
PU ACAD MEDICAL SCIENCES I R IRAN
PI TEHRAN
PA PO BOX 19395-5655, TEHRAN, 00000, IRAN
SN 1029-2977
EI 1735-3947
J9 ARCH IRAN MED
JI Arch. Iran. Med.
PD JAN
PY 2013
VL 16
IS 1
BP 4
EP 11
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 083UF
UT WOS:000314490000002
PM 23273227
DA 2025-06-11
ER

PT J
AU Bagul, PK
   Middela, H
   Matapally, S
   Padiya, R
   Bastia, T
   Madhusudana, K
   Reddy, BR
   Chakravarty, S
   Banerjee, SK
AF Bagul, Pankaj K.
   Middela, Harish
   Matapally, Saidulu
   Padiya, Raju
   Bastia, Tanmay
   Madhusudana, K.
   Reddy, B. Raghunath
   Chakravarty, Sumana
   Banerjee, Sanjay K.
TI Attenuation of insulin resistance, metabolic syndrome and hepatic
   oxidative stress by resveratrol in fructose-fed rats
SO PHARMACOLOGICAL RESEARCH
LA English
DT Article
DE Type-2 diabetes; Resveratrol; Metformin; Metabolic syndrome; Oxidative
   stress; NRF2
ID NITRIC-OXIDE; HYDROGEN-SULFIDE; OBESE RATS; SENSITIVITY; MECHANISMS
AB Metabolic syndrome and oxidative stress are common complications of type 2 diabetes mellitus. The present study was designed to determine whether resveratrol, a widely used nutritional supplement, can improve insulin sensitivity, metabolic complication as well as hepatic oxidative stress in fructose-fed rats. Male Sprague Dawley rats (180-200 g) were divided into four groups with 8 animals each. Fructose-fed insulin resistant group (Dia) animals were fed 65% fructose (Research diet, USA) for a period of 8 weeks, whereas control group (Con) animals were fed 65% cornstarch (Research Diet, USA). Resveratrol, 10 mg/kg/day (Dia + Resv) or metformin 300 mg/kg/day (Dia + Met) were administered orally to the 65% fructose-fed rats for 8 weeks. At the end of the feeding schedule, Dia group had insulin resistance along with increased blood glucose, triglyceride, uric acid and nitric oxide (NO) levels. Significant (p < 0.05) increase in hepatic TBARS and conjugated dienes, and significant (p < 0.05) decrease in hepatic SOD and vitamin C was observed in Dia group compared to Con group. Administration of metformin or resveratrol significantly (p < 0.05) normalized all the altered metabolic parameters. However, a marked insulin sensitizing action was only observed in the Dia + Resv group. Similarly, while metformin administration failed to normalize the increased TBARS levels and decreased SOD activity, resveratrol showed a more promising effect of all oxidative stress parameters measured in the present study. Attenuation of hepatic oxidative stress in fructose-fed rat liver after resveratrol administration was associated with significant (p < 0.05) increase in nuclear level of NRF2 compared with other groups. The present study demonstrates that resveratrol is more effective than metformin in improving insulin sensitivity, and attenuating metabolic syndrome and hepatic oxidative stress in fructose-fed rats. (c) 2012 Elsevier Ltd. All rights reserved.
C1 [Bagul, Pankaj K.; Middela, Harish; Matapally, Saidulu; Padiya, Raju; Bastia, Tanmay; Madhusudana, K.; Reddy, B. Raghunath; Chakravarty, Sumana; Banerjee, Sanjay K.] Indian Inst Chem Technol, Div Pharmacol & Chem Biol, Hyderabad 500607, Andhra Pradesh, India.
C3 Council of Scientific & Industrial Research (CSIR) - India; CSIR -
   Indian Institute of Chemical Technology (IICT)
RP Banerjee, SK (corresponding author), Indian Inst Chem Technol, Div Pharmacol & Chem Biol, Hyderabad 500607, Andhra Pradesh, India.
EM skbanerjee@iict.res.in
RI Chakravarty, Sumana/AAW-2823-2021; Dr. Pankaj K. Bagul, M.S/I-3867-2012;
   Mattapally, Saidulu/J-5811-2018
OI Mattapally, Saidulu/0000-0002-2788-3187; Banerjee, Sanjay
   k/0000-0002-0044-0984; , Raju Padiya/0000-0002-9772-9118; Banerjee,
   Sanjay/0000-0002-0008-0480
FU Ramalingaswami fellowship funds from Department of Biotechnology (DBT),
   Govt. of India; IICT institute fund; DBT [SR/SO/HS-110/2008]; Council of
   Scientific and Industrial Research (CSIR)
FX Financial support was provided by Ramalingaswami fellowship funds to SKB
   and SC from Department of Biotechnology (DBT), Govt. of India and in
   part, IICT institute fund. SKB has grant support from DBT
   (SR/SO/HS-110/2008). PKB is a Senior Research Fellow from Council of
   Scientific and Industrial Research (CSIR). We wish to thank Kumar
   organic products Ltd., Bangalore for providing gift sample of
   Resveratrol. We wish to thank Dr. K. Praveen Kumar for his excellent
   technical assistance and Dr. J. S. Yadav, Director, IICT, Hyderabad for
   providing all kind of support for this work. We would like to gratefully
   acknowledge Dr. Mohua Maulik for her suggestions and critical review of
   the manuscript.
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NR 39
TC 172
Z9 185
U1 2
U2 38
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 1043-6618
J9 PHARMACOL RES
JI Pharmacol. Res.
PD SEP
PY 2012
VL 66
IS 3
BP 260
EP 268
DI 10.1016/j.phrs.2012.05.003
PG 9
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 990EW
UT WOS:000307614800009
PM 22627169
DA 2025-06-11
ER

PT J
AU Razavi, BM
   Hosseinzadeh, H
AF Razavi, B. M.
   Hosseinzadeh, H.
TI A review of the effects of Nigella sativa L. and its constituent,
   thymoquinone, in metabolic syndrome
SO JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
LA English
DT Review
DE Nigella sativa; Thymoquinone; Metabolic syndrome; Cardiovascular
   disease; Hypertension; Diabetes; Dyslipidemia; Obesity
ID INDUCED OXIDATIVE STRESS; SERUM-LIPID PROFILE; DOUBLE-BLIND; DIETARY
   SUPPLEMENTATION; CARDIOVASCULAR-DISEASE; HEMATOLOGICAL VALUES;
   ISCHEMIA-REPERFUSION; MACERATED EXTRACTS; MAJOR CONSTITUENT;
   INSULIN-RELEASE
AB Background Metabolic syndrome is an important risk factor for cardiovascular disease (CVD) occurrence and mortality. CVDs are leading cause of death worldwide. Recently, there has been an increasing interest in the use of herbal medicines with more efficiency and minimal undesirable effects than chemical drugs for a variety of disorders including CVD. Nigella sativa and its active constituent, thymoquinone, have been documented to exhibit antidiabetic, antiobesity, hypotensive and hypolipidemic properties.
   Aim In this review, we discussed the most relevant articles to find out the role of N. sativa in different components of metabolic syndrome and CVD risk factors including high blood pressure, obesity, dyslipidemia and high blood glucose.
   Conclusions This review suggests a potential role of N. sativa and TQ in the management of metabolic syndrome, however more studies should be conducted to evaluate their effectiveness.
C1 [Razavi, B. M.] Mashhad Univ Med Sci, Sch Pharm, Targeted Drug Delivery Res Ctr, Dept Pharmacodynamy & Toxicol, Mashhad, Iran.
   [Hosseinzadeh, H.] Mashhad Univ Med Sci, Sch Pharm, Pharmaceut Res Ctr, Dept Pharmacodynamy & Toxicol, Mashhad, Iran.
C3 Mashhad University of Medical Sciences; Mashhad University of Medical
   Sciences
RP Hosseinzadeh, H (corresponding author), Mashhad Univ Med Sci, Sch Pharm, Pharmaceut Res Ctr, Dept Pharmacodynamy & Toxicol, Mashhad, Iran.
EM hosseinzadehh@mums.ac.ir
RI razavi, Bibi Marjan/AAY-5636-2020; Hosseinzadeh, Hossein/F-3013-2010
OI razavi, Bibi Marjan/0000-0002-7450-9286; Hosseinzadeh,
   Hossein/0000-0002-3483-851X
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NR 81
TC 96
Z9 100
U1 1
U2 28
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0391-4097
EI 1720-8386
J9 J ENDOCRINOL INVEST
JI J. Endocrinol. Invest.
PD NOV
PY 2014
VL 37
IS 11
BP 1031
EP 1040
DI 10.1007/s40618-014-0150-1
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA AS5YM
UT WOS:000344342400001
PM 25125023
DA 2025-06-11
ER

PT J
AU Duyuler, PT
   Duyuler, S
   Demir, M
   Elalmis, OU
   Güray, U
   Ileri, M
AF Duyuler, Pinar Turker
   Duyuler, Serkan
   Demir, Mevlut
   Elalmis, Ozgul Ucar
   Guray, Umit
   Ileri, Mehmet
TI Homocysteine, visceral adiposity-related novel cardiometabolic risk
   factors, and exaggerated blood pressure response to the exercise
   treadmill test
SO BLOOD PRESSURE MONITORING
LA English
DT Article
DE blood pressure; epicardial fat; exercise; hepatic steatosis;
   homocysteine
ID EPICARDIAL FAT THICKNESS; INSULIN-RESISTANCE; ESSENTIAL-HYPERTENSION;
   METABOLIC SYNDROME; TISSUE THICKNESS; ASSOCIATION; OBESITY;
   METAANALYSIS; STRESS
AB ObjectiveExaggerated blood pressure response to exercise is a risk factor for the development of future hypertension. In this study, we aimed to investigate the association between homocysteine, epicardial fat thickness, nonalcoholic hepatic steatosis, and exaggerated blood pressure response to exercise.Participants and methodsWe included 44 normotensive and 40 patients with exaggerated blood pressure response to exercise who have normal resting blood pressure and without a previous diagnosis of hypertension. All patients underwent treadmill exercise test and clinical, ultrasonographic, and echocardiographic evaluation. Exaggerated blood pressure response to exercise is defined as peak exercise systolic blood pressure of at least 210mmHg in men and at least 190mmHg in women. Homocysteine and other biochemical parameters were determined with standardized automated laboratory tests.ResultsMean age of all participants is 47.98.5 years, and 36 of 84 participants were female. The frequency of diabetes mellitus in both groups was similar (P=0.250). Homeostasis model assessment index-insulin resistance had a statistically insignificant trend to be higher in a patient with exercise hypertension (P=0.058). The nonalcoholic fatty liver was more frequent in patients with exercise hypertension (13.6 vs. 47.5%, P=0.002). Epicardial fat thickness was increased in patients with exercise hypertension (5.5 +/- 1.5 vs. 7.3 +/- 1.1mm; P=0.001). However, homocysteine levels did not significantly differ between normotensive and exercise hypertensive patients [12.3mol/l (5.7-16.9mol/l) vs. 13mol/l (5.9-28.3mol/l); P=0.883].ConclusionIn our study, homocysteine levels were not associated with exaggerated blood pressure response to exercise; however, fatty liver and epicardial fat thickness as visceral adiposity-related cardiometabolic risk factors were significantly related with exaggerated blood pressure response to exercise in patients without a previous diagnosis of hypertension. Copyright (C) 2017 Wolters Kluwer Health, Inc. All rights reserved.
C1 [Duyuler, Pinar Turker; Demir, Mevlut; Elalmis, Ozgul Ucar; Guray, Umit; Ileri, Mehmet] Ankara Numune Training & Res Hosp, Dept Cardiol, Ankara, Turkey.
   [Duyuler, Serkan] Acibadem Ankara Hosp, Dept Cardiol, 630 Sokak 6 Oran, TR-06650 Ankara, Turkey.
C3 Ankara Numune Training & Research Hospital; Acibadem Hospitals Group
RP Duyuler, S (corresponding author), Acibadem Ankara Hosp, Dept Cardiol, 630 Sokak 6 Oran, TR-06650 Ankara, Turkey.
EM serkanduyuler@yahoo.com
RI Türker Duyuler, Pınar/GXV-0259-2022; Ileri, Mehmet/A-6525-2018; guray,
   umit/AAQ-9812-2021; Duyuler, Serkan/F-3514-2019; DEMIR,
   MEVLUT/HJP-9815-2023
OI DEMIR, MEVLUT/0000-0002-7484-9969; GURAY, UMIT/0000-0002-6604-2970
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NR 35
TC 6
Z9 6
U1 0
U2 19
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1359-5237
EI 1473-5725
J9 BLOOD PRESS MONIT
JI Blood Press. Monit.
PD DEC
PY 2017
VL 22
IS 6
BP 333
EP 338
DI 10.1097/MBP.0000000000000300
PG 6
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA FN4EL
UT WOS:000415956700005
PM 29076884
DA 2025-06-11
ER

PT J
AU Talon, LD
   de Oliveira, EP
   Moreto, F
   Portero-McLellan, KC
   Burini, RC
AF Talon, Lidiana de Camargo
   de Oliveira, Erick Prado
   Moreto, Fernando
   Portero-McLellan, Katia Cristina
   Burini, Roberto Carlos
TI Omega-3 fatty acids supplementation decreases metabolic syndrome
   prevalence after lifestyle modification program
SO JOURNAL OF FUNCTIONAL FOODS
LA English
DT Article
DE Metabolic syndrome; Lifestyle change; Omega-3 fatty acids; Obesity;
   Inflammation; Oxidative stress
ID N-3 FATTY-ACIDS; CARDIOVASCULAR-DISEASE RISK; LOW-DENSITY-LIPOPROTEIN;
   HDL CHOLESTEROL LEVELS; FISH-OIL; AEROBIC EXERCISE; BLOOD-PRESSURE;
   PPAR-GAMMA; METAANALYSIS; PLASMA
AB The additional effect of omega-3 supplementation in association with lifestyle modification program (LSMP) in free living-adults was evaluated. We studied 39 adults (control group with LSMP (Cl, n = 16) and LSMP plus supplementation of 3 g of fish oil per day (360 mg of docosahexaenoic acid and 540 mg of eicosapentaenoic acid) (G2, n = 23)) during 20 weeks. The fish oil group showed a significant decrease in waist circumference (1.3%) followed by metabolic syndrome reduction (29%) mainly due to normalization of blood pressure (33.3%) and triacylglycerol (27.3%). Omega-3 supplementation provided additional benefits to LSMP in the resolution of metabolic syndrome. (C) 2015 Elsevier Ltd. All rights reserved.
C1 [Talon, Lidiana de Camargo; Moreto, Fernando; Portero-McLellan, Katia Cristina; Burini, Roberto Carlos] UNESP, Sch Med, Dept Publ Hlth, Ctr Phys Exercise & Nutr Metab, Botucatu, SP, Brazil.
   [Talon, Lidiana de Camargo; Moreto, Fernando] UNESP, Sch Med, Dept Pathol, Botucatu, SP, Brazil.
   [de Oliveira, Erick Prado] Univ Fed Uberlandia, Sch Med, BR-38400 Uberlandia, MG, Brazil.
C3 Universidade Estadual Paulista; Universidade Estadual Paulista;
   Universidade Federal de Uberlandia
RP Burini, RC (corresponding author), UNESP, Sch Med, Dept Publ Hlth, Ctr Phys Exercise & Nutr Metab, Botucatu, SP, Brazil.
EM burini@fmb.unesp.br
RI de Oliveira, Erick/D-1138-2011; McLellan, Katia/I-2556-2012; Moreto,
   Fernando/I-7690-2013
OI P. de Oliveira, Erick/0000-0001-8989-8344; Moreto,
   Fernando/0000-0002-4028-0014
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NR 54
TC 19
Z9 22
U1 0
U2 7
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1756-4646
J9 J FUNCT FOODS
JI J. Funct. Food.
PD DEC
PY 2015
VL 19
BP 922
EP 928
DI 10.1016/j.jff.2015.01.022
PN B
PG 7
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA CY2LT
UT WOS:000366240900014
OA hybrid
DA 2025-06-11
ER

PT J
AU Shiraishi, M
   Tanaka, M
   Okada, H
   Hashimoto, Y
   Nakagawa, S
   Kumagai, M
   Yamamoto, T
   Nishimura, H
   Oda, Y
   Fukui, M
AF Shiraishi, Makoto
   Tanaka, Muhei
   Okada, Hiroshi
   Hashimoto, Yoshitaka
   Nakagawa, Shinichi
   Kumagai, Muneaki
   Yamamoto, Teruyuki
   Nishimura, Hiromi
   Oda, Yohei
   Fukui, Michiaki
TI Potential impact of the joint association of total bilirubin and
   gamma-glutamyltransferase with metabolic syndrome
SO DIABETOLOGY & METABOLIC SYNDROME
LA English
DT Article
DE Bilirubin; Gamma-glutamyltransferase; Metabolic syndrome
ID INSULIN-RESISTANCE; FATTY LIVER; BILIVERDIN REDUCTASE; OXIDATIVE STRESS;
   SERUM BILIRUBIN; PREDICTOR; RISK; ATHEROSCLEROSIS; TRANSPEPTIDASE;
   INFLAMMATION
AB BackgroundMetabolic syndrome is characterized by the clustering of different metabolic abnormalities. Total bilirubin and gamma-glutamyltransferase (GGT) levels have been reported to be associated with this condition. However, the extent to which the interaction between these parameters affects metabolic syndrome is unknown. Therefore, we examined the association of total bilirubin and GGT levels with metabolic syndrome, and investigated the combined effect of the two parameters.MethodsIn this retrospective cohort study, we analyzed 8992 middle-aged Japanese subjects (4586 men, 4406 women; mean age, 44.89.3years) without metabolic syndrome from a cohort of employees undergoing annual health examinations. They were divided into four groups according to median total bilirubin and GGT levels: both-low, GGT-high, total bilirubin-high, and both-high. The incident of metabolic syndrome was evaluated during a follow-up of 2.81.2years.ResultsThe incident rate of metabolic syndrome during the follow-up was 4.6% in the both-low group, 12.1% in the GGT-high group, 2.7% in the total bilirubin-high group, and 10.6% in the both-high group. Total bilirubin and GGT have an interaction effect on the risk of incident metabolic syndrome (p=0.0222). The both-low [hazard ratio (HR), 1.37; 95% confidence interval (CI) 1.002-1.89], GGT-high (HR, 1.88; 95% CI 1.42-2.52), and both-high (HR, 2.07; 95% CI 1.56-2.80) groups showed an increased adjusted HR for incident metabolic syndrome after adjusting for covariates compared with the total bilirubin-high group.ConclusionsThe simultaneous presence of high total bilirubin and low GGT levels may be associated with a lower incidence of metabolic syndrome.
C1 [Shiraishi, Makoto; Tanaka, Muhei; Hashimoto, Yoshitaka; Oda, Yohei; Fukui, Michiaki] Kyoto Prefectural Univ Med, Dept Endocrinol & Metab, Grad Sch Med Sci, Kamigyo Ku, 465 Kajii Cho, Kyoto 6028566, Japan.
   [Okada, Hiroshi] Matsushita Mem Hosp, Dept Internal Med, Osaka, Japan.
   [Nakagawa, Shinichi; Kumagai, Muneaki; Yamamoto, Teruyuki; Nishimura, Hiromi] Med Corp Soukenkai, Nishimura Clin, Kyoto, Japan.
C3 Kyoto Prefectural University of Medicine
RP Tanaka, M (corresponding author), Kyoto Prefectural Univ Med, Dept Endocrinol & Metab, Grad Sch Med Sci, Kamigyo Ku, 465 Kajii Cho, Kyoto 6028566, Japan.
EM hb14a23@stu.kpu-m.ac.jp; muhei-t@koto.kpu-m.ac.jp
RI Nakagawa, Shinichi/I-4192-2014; Hashimoto, Yoshitaka/AAH-8503-2020;
   Okada, Hiroshi/AAG-1588-2020; SHIRAISHI, Makoto/HOF-3529-2023
OI Hashimoto, Yoshitaka/0000-0002-8794-0550; Okada,
   Hiroshi/0000-0002-1707-970X; SHIRAISHI, Makoto/0000-0002-3734-2085;
   Tanaka, Muhei/0000-0002-1979-1565
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NR 37
TC 12
Z9 13
U1 0
U2 4
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1758-5996
J9 DIABETOL METAB SYNDR
JI Diabetol. Metab. Syndr.
PD FEB 4
PY 2019
VL 11
AR 12
DI 10.1186/s13098-019-0408-z
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA HK2CT
UT WOS:000457716700001
PM 30740147
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Benchoula, K
   Khatib, A
   Jaffar, A
   Ahmed, QU
   Sulaiman, WMAW
   Abd Wahab, R
   El-Seedi, HR
AF Benchoula, Khaled
   Khatib, Alfi
   Jaffar, Ashika
   Ahmed, Qamar Udin
   Sulaiman, Wan Mohd Azizi Wan
   Abd Wahab, Ridhwan
   El-Seedi, Hesham R.
TI The promise of zebrafish as a model of metabolic syndrome
SO EXPERIMENTAL ANIMALS
LA English
DT Review
DE diabetes; hypertension; metabolic syndrome; obesity; zebrafish
ID DIET-INDUCED OBESITY; ANIMAL-MODELS; GLUCOSE-METABOLISM; OXIDATIVE
   STRESS; PANCREAS; REGENERATION; GENES; HYPERGLYCEMIA; MODULATION;
   ACTIVATION
AB Metabolic syndrome is a cluster including hyperglycaemia, obesity, hypertension, and hypertriglyceridaemia as a result of biochemical and physiological alterations and can increase the risk of cardiovascular disease and diabetes. Fundamental research on this disease requires validated animal models. One potential animal model that is rapidly gaining in popularity is zebrafish (Danio rerio). The use of zebrafish as an animal model conveys several advantages, including high human genetic homology, transparent embryos and larvae that allow easier visualization. This review discusses how zebrafish models contribute to the development of metabolic syndrome studies. Different diseases in the cluster of metabolic syndrome, such as hyperglycaemia, obesity, diabetes, and hypertriglyceridaemia, have been successfully studied using zebrafish; and the model is promising for hypertension and cardiovascular metabolic-related diseases due to its genetic similarity to mammals. Genetic mutation, chemical induction, and dietary alteration are among the tools used to improve zebrafish models. This field is expanding, and thus, more effective and efficient techniques are currently developed to fulfil the increasing demand for thorough investigations.
C1 [Benchoula, Khaled; Sulaiman, Wan Mohd Azizi Wan] Int Islamic Univ Malaysia, Dept Basic Med Sci, Kulliyyah Pharm, Sultan Ahmad Shah St, Kuantan 25200, Pahang, Malaysia.
   [Khatib, Alfi; Ahmed, Qamar Udin] Int Islamic Univ Malaysia, Dept Pharmaceut Chem, Kulliyyah Pharm, Pharmacognosy Res Grp, Sultan Ahmad Shah St, Kuantan 25200, Pahang, Malaysia.
   [Khatib, Alfi] Int Islamic Univ Malaysia, Kulliyyah Sci, Cent Res & Anim Facil CREAM, Sultan Ahamad Shah St, Kuantan 25200, Pahang, Malaysia.
   [Jaffar, Ashika] VIT Univ, Sch Biosci & Technol, Vellore 632014, Tamil Nadu, India.
   [Abd Wahab, Ridhwan] Int Islamic Univ Malaysia, Kulliyah Allied Hlth Sci, Sultan Ahmad Shah St, Kuantan 25200, Pahang, Malaysia.
   [El-Seedi, Hesham R.] Uppsala Univ, Biomed Ctr, Dept Med Chem, Pharmacognosy Grp, Box 574, SE-75123 Uppsala, Sweden.
   [El-Seedi, Hesham R.] Alrayan Med Coll, Medina 42541, Saudi Arabia.
C3 International Islamic University Malaysia; International Islamic
   University Malaysia; International Islamic University Malaysia; Vellore
   Institute of Technology (VIT); VIT Vellore; International Islamic
   University Malaysia; Uppsala University; Al-Rayan Colleges
RP Khatib, A (corresponding author), Int Islamic Univ Malaysia, Dept Pharmaceut Chem, Kulliyyah Pharm, Pharmacognosy Res Grp, Sultan Ahmad Shah St, Kuantan 25200, Pahang, Malaysia.; Khatib, A (corresponding author), Int Islamic Univ Malaysia, Kulliyyah Sci, Cent Res & Anim Facil CREAM, Sultan Ahamad Shah St, Kuantan 25200, Pahang, Malaysia.
EM alfikhatib@iium.edu.my
RI benchoula, khaled/HGD-4083-2022; Ahmed, Qamar/D-7761-2014; El-Seedi,
   Hesham/C-8627-2018
OI Ahmed, Qamar Uddin/0000-0003-0565-3222
FU International Islamic University Malaysia [PRIGS18-027-0027]; VR
   (Stockholm, Sweden) [2016-05908]
FX The authors wish to thank the International Islamic University Malaysia
   for Publication Research Initiative Grant Scheme funding
   (PRIGS18-027-0027) and extend their appreciation to VR (Stockholm,
   Sweden) Grant number 2016-05908 for generous financial support awarded
   to H.R.E.
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NR 80
TC 37
Z9 43
U1 5
U2 37
PU INT PRESS EDITING CENTRE INC
PI TOKYO
PA 1-2-3 SUGAMO, TOSHIMA-KU, TOKYO, 170 0002, JAPAN
SN 1341-1357
EI 1881-7122
J9 EXP ANIM TOKYO
JI Exp. Anim.
PY 2019
VL 68
IS 4
BP 407
EP 416
DI 10.1538/expanim.18-0168
PG 10
WC Veterinary Sciences; Zoology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences; Zoology
GA JK6SD
UT WOS:000494971400003
PM 31118344
OA Green Accepted, Green Published, gold
DA 2025-06-11
ER

PT J
AU González, HM
   Tarraf, W
   Haan, MN
AF Gonzalez, Hector M.
   Tarraf, Wassim
   Haan, Mary N.
TI The Metabolic Syndrome, Biomarkers, and the Acculturation-Health
   Relationship Among Older Mexican Americans
SO JOURNAL OF AGING AND HEALTH
LA English
DT Article
DE active life expectancy; migration; epidemiology; Latinos/Hispanics
ID UNITED-STATES; PREVALENCE; LATINOS; HISPANICS; MORTALITY
AB Objective: To examine the acculturation-health relationship using metabolic syndrome biomarkers. Method: Cross-sectional sample data. Participants: 1,789 Mexican Americans (60 years and older) from northern California. Main Outcome: Biomarkers (waist circumference, blood pressure, fasting plasma glucose, triglycerides, and high-density lipids) were used to construct the metabolic syndrome indicator using American Heart Association criteria. Main Predictor: Acculturation Rating Scale for Mexican Americans-II scores. Results: Higher acculturation scores were associated with a significantly lower risk for the metabolic syndrome for foreign-born, but not U.S.-born, Mexican Americans. Conclusion: Immigrant health advantages over U.S.-born Mexican Americans are not evident in older adulthood. Higher acculturation was associated with lowered metabolic syndrome risk among older foreign-born Mexican Americans. This suggests that the prevailing acculturative stress hypothesis may not apply to the health of older adults and that any negative relationship between acculturation and health found in younger adults may yield to different developmental health influences in later adulthood.
C1 [Gonzalez, Hector M.] Wayne State Univ, Inst Gerontol, Detroit, MI 48202 USA.
   [Gonzalez, Hector M.] Univ Michigan, Ann Arbor, MI 48109 USA.
   [Haan, Mary N.] Univ Calif San Francisco, San Francisco, CA 94143 USA.
C3 Wayne State University; University of Michigan System; University of
   Michigan; University of California System; University of California San
   Francisco
RP González, HM (corresponding author), Wayne State Univ, Inst Gerontol, 87 E Ferry St,226 Knapp Bldg, Detroit, MI 48202 USA.
EM hmgonzalez@med.wayne.edu
RI Haan, Mary/Y-9354-2018; Gonzalez, Hector/AAV-7576-2021
FU NHLBI NIH HHS [N01 HC065233, HC 65233] Funding Source: Medline; NIA NIH
   HHS [R03 AG033751, AG 33751, AG 12975, R01 AG012975] Funding Source:
   Medline; NIDDK NIH HHS [R01 DK060753] Funding Source: Medline; NIMH NIH
   HHS [R01 MH084994, MH 084994] Funding Source: Medline
CR ADLER NE, 1994, AM PSYCHOL, V49, P15, DOI 10.1037/0003-066X.49.1.15
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NR 26
TC 10
Z9 20
U1 0
U2 9
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0898-2643
EI 1552-6887
J9 J AGING HEALTH
JI J. Aging Health
PD OCT
PY 2011
VL 23
IS 7
SI SI
BP 1101
EP 1115
DI 10.1177/0898264311421371
PG 15
WC Gerontology; Health Policy & Services
WE Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Health Care Sciences & Services
GA 823XZ
UT WOS:000295162600005
PM 21948772
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Koziol-Kozakowska, A
   Wójcik, M
   Herceg-Cavrak, V
   Cobal, S
   Radovanovic, D
   Alvarez-Pitti, J
   Hartgring, I
   Piórecka, B
   Gabbianelli, R
   Drozdz, D
AF Koziol-Kozakowska, Agnieszka
   Wojcik, Malgorzata
   Herceg-Cavrak, Vesna
   Cobal, Sara
   Radovanovic, Dragan
   Alvarez-Pitti, Julio
   Hartgring, Isa
   Piorecka, Beata
   Gabbianelli, Rosita
   Drozdz, Dorota
TI Dietary Strategies in the Prevention and Treatment of Hypertension in
   Children and Adolescents: A Narrative Review
SO NUTRIENTS
LA English
DT Review
DE hypertension; blood pressure; obesity; children diet; DASH diet
ID CHILDHOOD METABOLIC SYNDROME; SUGAR-SWEETENED BEVERAGES; LIFE-STYLE
   INTERVENTIONS; STOP HYPERTENSION; BLOOD-PRESSURE; DASH DIET; ENERGY
   DRINKS; PEDIATRIC GASTROENTEROLOGY; CARDIOMETABOLIC RISK; CARDIOVASCULAR
   RISK
AB This study aims to gather information on effective dietary strategies for the prevention and treatment of hypertension (HTN) in children and adolescents. It discusses specific nutritional models such as the Diet Approaches to Stop Hypertension (DASH diet), traditional Asian diets, plant-based diets, the Southern European traditional Atlantic diet, and the Mediterranean diet, highlighting the benefits of these approaches. The manuscript also addresses dehydration resulting from insufficient fluid intake among children, as well as the consumption of inappropriate beverages, like soft drinks and energy drinks, which contributes to the development of HTN. Additionally, it examines the role of oxidative stress in the pathomechanism of HTN in children, particularly in relation to the antioxidant potential of food components such as selenium, magnesium, and selected vitamins. The relationship between sodium and potassium intake from food and the development of HTN in children is also explored. Finally, this study discusses public health strategies for the prevention of HTN in children. A comprehensive search was performed across multiple databases, such as PubMed/MEDLINE, the Cochrane Library, Science Direct, and EBSCO. This search focused on locating English-language meta-analyses, systematic reviews, randomized clinical trials, and observational studies from around the globe.
C1 [Koziol-Kozakowska, Agnieszka] Jagiellonian Univ, Inst Pediat, Med Coll, Dept Pediat Gastroenterol & Nutr,Fac Med, Wielicka 265 St, PL-30663 Krakow, Poland.
   [Wojcik, Malgorzata] Jagiellonian Univ, Inst Pediat, Chair Pediat, Dept Pediat & Adolescent Endocrinol,Fac Med,Med Co, Wielicka 265 St, PL-30663 Krakow, Poland.
   [Wojcik, Malgorzata; Drozdz, Dorota] Univ Childrens Hosp Krakow, Wielicka 265 St, PL-30663 Krakow, Poland.
   [Herceg-Cavrak, Vesna] Libertas Int Univ, Fac Hlth Sci, Zagreb 10000, Croatia.
   [Cobal, Sara] Croatian Med Assoc, Zagreb 10000, Croatia.
   [Radovanovic, Dragan] Univ Nis, Fac Sport & Phys Educ, Dept Med Sci, Nish 18000, Serbia.
   [Alvarez-Pitti, Julio] Univ Valencia, Consorcio Hosp Gen, Pediat Dept, Valencia 46014, Spain.
   [Alvarez-Pitti, Julio] Inst Salud Carlos III, CIBER Fisiopatol Obes & Nutr CIBEROBN, Madrid 28029, Spain.
   [Alvarez-Pitti, Julio; Hartgring, Isa] Univ Valencia, Consorcio Hosp Gen, Fdn Invest, Innovat Paediat & Technol iPEDITEC Res Grp, Valencia 46014, Spain.
   [Piorecka, Beata] Jagiellonian Univ Med Coll, Inst Publ Hlth, Fac Hlth Sci, Dept Nutr & Drug Res, Skawinska 8 St, PL-31066 Krakow, Poland.
   [Gabbianelli, Rosita] Univ Camerino, Sch Pharm, Unit Mol Biol & Nutrigen, I-62032 Camerino, MC, Italy.
   [Drozdz, Dorota] Jagiellonian Univ Med Coll, Inst Pediat, Chair Pediat, Dept Pediat Nephrol & Hypertens, Wielicka 265 St, PL-30663 Krakow, Poland.
C3 Jagiellonian University; Collegium Medicum Jagiellonian University;
   Jagiellonian University; Collegium Medicum Jagiellonian University;
   University of Nis; University of Valencia; CIBER - Centro de
   Investigacion Biomedica en Red; CIBEROBN; Instituto de Salud Carlos III;
   University of Valencia; Jagiellonian University; Collegium Medicum
   Jagiellonian University; University of Camerino; Jagiellonian
   University; Collegium Medicum Jagiellonian University
RP Koziol-Kozakowska, A (corresponding author), Jagiellonian Univ, Inst Pediat, Med Coll, Dept Pediat Gastroenterol & Nutr,Fac Med, Wielicka 265 St, PL-30663 Krakow, Poland.
EM agnieszka.koziol-kozakowska@uj.edu.pl; malgorzata.wojcik@uj.edu.pl;
   vherceg@gmail.com; cobal.epode@hlz.hr; dragan.radovanovic@fsfv.ni.ac.rs;
   japnago@gmail.com; isahartgring@gmail.com; beata.piorecka@uj.edu.pl;
   rosita.gabbianelli@unicam.it; dorota.drozdz@uj.edu.pl
RI Herceg-Čavrak, Vesna/JEZ-5609-2023; Radovanovic, Dragan/JZT-2755-2024;
   Wójcik, Małgorzata/AAJ-2856-2020; Kozioł-Kozakowska,
   Agnieszka/JAC-3936-2023; Koziol-Kozakowska, Agnieszka/U-4062-2018;
   Alvarez Pitti, Julio/M-2552-2018; Piorecka, Beata/GWU-9572-2022
OI Koziol-Kozakowska, Agnieszka/0000-0003-4770-5641; Alvarez Pitti,
   Julio/0000-0003-0452-7822; Radovanovic, Dragan/0000-0002-1690-2127;
   Drozdz, Dorota/0000-0002-1281-1164; Wojcik,
   Malgorzata/0000-0003-3889-1913; Piorecka, Beata/0000-0001-7323-4797
FU COST (European Cooperation in Science and Technology) [CA19115]
FX This publication is based on the work of the COST Action HyperChildNET
   (CA19115), with the support of COST (European Cooperation in Science and
   Technology).
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NR 110
TC 2
Z9 2
U1 4
U2 6
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD AUG
PY 2024
VL 16
IS 16
AR 2786
DI 10.3390/nu16162786
PG 19
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA E8X1M
UT WOS:001305763900001
PM 39203922
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Aswathi, P
   Martinez, LW
   Radha, S
AF Aswathi, Pootheri
   Martinez, Lopez Wilner
   Radha, Saraswathy
TI Action of Reactive Oxygen Species in Metabolic Diseases employed as
   Biomarkers of Oxidative Stress
SO RESEARCH JOURNAL OF BIOTECHNOLOGY
LA English
DT Review
DE Biomarkers; Metabolic Diseases; Oxidative Stress
ID LIPID-PEROXIDATION; OBESITY; ANTIOXIDANTS; ASSOCIATION; RESISTANCE;
   HYPERTENSION; SUPEROXIDE; PROTEINS
AB Metabolic syndrome is a public health problem that has been rapidly increasing over the last century. Oxidative stress plays a major pathological role in the development of metabolic diseases such as obesity, hypertension and type 2 diabetes. Oxidative stress is an imbalance between reactive oxygen species (ROS), reactive nitrogen species (RNS), free radicals and antioxidant defences (superoxide nitric oxide, hydroxyl radical, glutathione peroxidase). Oxygen is essential for the living system. At the same time, oxygen may also be dangerous to the same biological system. ROS can injure cellular macromolecules leading to apoptosis and necrosis. ROS plays a vital role in physiological processes and a favourable role in the immune system.
   This review discusses the effects of oxidative stress and possible biomarkers that can be employed to determine the degree of development of metabolic diseases. The growth in the formation of oxidizing species in the metabolic syndrome has been considered as a main underlying mechanism for mitochondrial dysfunction, accumulation of protein and lipid oxidation merchandise, as well as an impairment of the antioxidant systems. These oxidative modifications are recognized as applicable oxidative stress biomarkers and are probably capable of clarifying the position of reactive oxygen and the examination of the severity of the condition aided by the nitrogen species involved in the metabolic syndrome's aetiology.
C1 [Aswathi, Pootheri; Radha, Saraswathy] Vellore Inst Technol, Sch Biosci & Technol, Dept Biomed Sci, Biomed Genet Res Lab, Vellore 632014, Tamil Nadu, India.
   [Martinez, Lopez Wilner] Inst Invest Biol Clemente Estable, Epigenet & Genom Instabil Lab, Ave Italia 3318, Montevideo 11600, Uruguay.
C3 Vellore Institute of Technology (VIT); VIT Vellore; Instituto de
   Investigaciones Biologicas Clemente Estable Uruguay
RP Radha, S (corresponding author), Vellore Inst Technol, Sch Biosci & Technol, Dept Biomed Sci, Biomed Genet Res Lab, Vellore 632014, Tamil Nadu, India.
EM radhasaraswathy@vit.ac.in
FU VIT University, Vellore, Tamil Nadu, India
FX The authors acknowledge VIT University, Vellore, Tamil Nadu, India. A.P
   is grateful to VIT for providing a teaching cum research assistant (TRA)
   fellowship.
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NR 62
TC 2
Z9 2
U1 0
U2 4
PU RESEARCH JOURNAL BIOTECHNOLOGY
PI INDORE
PA SECTOR A-80, SCHEME NO 54, VIJAY NAGAR, A B ROAD, INDORE, 452 010 MP,
   INDIA
SN 0973-6263
EI 2278-4535
J9 RES J BIOTECHNOL
JI Res. J. Biotechnol.
PD DEC
PY 2022
VL 17
IS 12
BP 207
EP 215
PG 9
WC Biotechnology & Applied Microbiology
WE Emerging Sources Citation Index (ESCI)
SC Biotechnology & Applied Microbiology
GA 6R1LG
UT WOS:000892070300022
DA 2025-06-11
ER

PT J
AU Hennessy, S
   Cocoman, AM
AF Hennessy, Sinead
   Cocoman, Angela M.
TI What Is the Impact of Targeted Health Education for Mental Health Nurses
   in the Provision of Physical Health Care? An Integrated Literature
   Review
SO ISSUES IN MENTAL HEALTH NURSING
LA English
DT Review
ID SERVICE USERS; ILLNESS; PEOPLE; NEEDS; PRE; CONFIDENCE; ATTITUDES;
   CONSUMERS
AB Individuals with a severe mental illness have a gap in life expectancy of up to 20 years in comparison to the general population. Nurses who work in mental health services have been identified as best placed to improve the physical health outcomes of individuals with mental illness. The literature identifies a lack of nursing knowledge related to physical health care and the presence of metabolic syndrome which is impeding nurses in providing essential physical health care to patients. An integrated literature review was carried out due to the dearth of research evidence pertaining to the impact of targeted education specifically with psychiatric/mental health nurses in the provision of physical healthcare. A search for literature included the following databases: CINAHL, Medline, PsycINFO, Embase and Web of Science revealed nine studies: seven quantitative, one qualitative and one mixed method. Qualitative synthesis has shed light on the value of targeted education on improving knowledge and skills in providing physical health care that can then be translated into clinical practice. Targeted education in physical healthcare grows psychiatric/mental health nurse's confidence and develops the skills necessary to enable them to screen and monitor and offer range of physical health interventions to individuals with severe mental illness.Accessible summary
   The poor physical health outcomes and premature death of individuals with severe mental illness is of growing concern; a contributing factor is a lack of knowledge and confidence amongst psychiatric/mental health nurses to providing physical health screening and intervening in preventable diseases such as cardiovascular disease, stroke cancer, and type 2 diabetes mellitus.
   An integrated literature review was used to ascertain if targeted education on physical health care can improve the knowledge base of psychiatric/mental health nurses within physical health care.
   Nine studies were critically appraised, and the data reduced using a narrative synthesis that tells a story of the findings from these research studies.
   The review found that targeted education with psychiatric/mental health nurses does result in a statistical increase in knowledge This review finds that nurses have not been regularly supported with physical health education to alter existing practices. This lack of knowledge within physical healthcare is hindering psychiatric/mental health nurses to fully engaging in physical health care activities in practice.
C1 [Hennessy, Sinead; Cocoman, Angela M.] Dublin City Univ, Fac Sci & Hlth Nursing & Human Sci, Dublin, Ireland.
C3 Dublin City University
RP Cocoman, AM (corresponding author), Dublin City Univ, Sch Nursing & Human Sci, Fac Sci & Hlth, Dublin 9, Ireland.
EM angela.cocoman@dcu.ie
RI Cocoman, Angela/V-9506-2019
OI Cocoman, Dr. Angela/0000-0002-5933-7682
CR [Anonymous], 2006, IDF CONS WORLDW DEF
   [Anonymous], 2014, Physical health and well-being in mental health nursing: clinical skills for practice
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NR 40
TC 19
Z9 21
U1 0
U2 15
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 0161-2840
EI 1096-4673
J9 ISSUES MENT HEALTH N
JI Issues Ment. Health Nurs.
PY 2018
VL 39
IS 8
BP 700
EP 706
DI 10.1080/01612840.2018.1429509
PG 7
WC Nursing; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Psychiatry
GA HK9QU
UT WOS:000458327600010
PM 29465277
DA 2025-06-11
ER

PT J
AU Björntorp, P
   Holm, G
   Rosmond, R
   Folkow, B
AF Björntorp, P
   Holm, G
   Rosmond, R
   Folkow, B
TI Hypertension and the metabolic syndrome:: Closely related central
   origin?
SO BLOOD PRESSURE
LA English
DT Review
DE cortisol; hypothalamus; insulin; leptin; metabolic syndrome; primary
   hypertension; stress; sympathetic nervous system
ID ADIPOSE-TISSUE DISTRIBUTION; MUSCLE-FIBER COMPOSITION; BODY-FAT
   DISTRIBUTION; NERVOUS-SYSTEM ACTIVITY; MIDDLE-AGED MEN; BLOOD-PRESSURE;
   INSULIN-RESISTANCE; BORDERLINE HYPERTENSION; CYNOMOLGUS MONKEYS;
   PSYCHOSOCIAL STRESS
AB In primary hypertension a mild hyperresponsiveness of hypothalamic, sympatho-hormonal centres to psychosocial stimuli forms a major pathogenetic element, although high salt intake in some subjects may contribute via volume expansion. Hypertension is often associated with another "civilisation" disorder, the metabolic syndrome, defined as abdominal obesity, insulin resistance and dyslipidaemia. According to recent research, the metabolic syndrome has in all likelihood a central neuroendocrine origin in the form of enhanced engagement of the hypothalamic-pituitary-adrenal (HPA) axis. Here the peripheral endocrine perturbations act as triggers for both central obesity and the metabolic abnormalities.
   The reaction pattern characterising early primary hypertension is identical with, or closely related to, the "defence reaction", while that leading to the metabolic syndrome is similar to that of the "defeat reaction". Both belong to the primitive survival reactions, common to all mammals, though man can control, or at least mask, his outward-behavioural part but not the neuro-hormonal expressions.
   Animal experiments show how frequent or chronic mental challenges are capable of engaging these limbic-hypothalamic centres, affecting blood pressure regulation as well as endocrine-metabolic regulation. Furthermore, these centres are tightly coupled functionally, and their signals to the periphery often combined. On a long-term basis their engagements appear to be decisive for the development of both primary hypertension and the metabolic syndrome, as suggested by intervention studies. In both these "disorders of civilisation", observations strongly indicate that psychosocial stress, socioeconomic handicaps, lack of exercise, abuse and also psychiatric traits are involved.
   Such factors, characteristic of current competitive society, probably cause mixed engagements of the two above-mentioned neuro-hormonal patterns, and thereby, with time, primary hypertension and the metabolic syndrome, with end-paints such as coronary artery disease, diabetes mellitus type2 and stroke. Susceptibilty to such developments is probably enhanced by genetic factors
   This overview of recent developments therefore serves to emphasise how both primary hypertension and the metabolic syndrome seem to have a common central origin. Central regulatory factors are often overlooked, partly because it is not realised that limbic-hypothalamic centres are the major regulators of both circulatory and metabolic events, and partly because of the long period of time required before these disease end-points are reached.
C1 Univ Gothenburg, Dept Heart & Lung Dis, Gothenburg, Sweden.
   Univ Gothenburg, Dept Physiol, Gothenburg, Sweden.
C3 University of Gothenburg; University of Gothenburg
RP Sahlgrens Univ Hosp, Dept Heart & Lung Dis, SE-41345 Gothenburg, Sweden.
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NR 96
TC 68
Z9 80
U1 0
U2 12
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0803-7051
EI 1651-1999
J9 BLOOD PRESSURE
JI Blood Pressure
PY 2000
VL 9
IS 2-3
BP 71
EP 82
DI 10.1080/08037050050151762
PG 12
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 320KD
UT WOS:000087399600002
PM 10855728
OA Bronze
DA 2025-06-11
ER

PT J
AU Gazzaruso, C
   Solerte, SB
   De Amici, E
   Mancini, M
   Pujia, A
   Fratino, P
   Giustina, A
   Garzaniti, A
AF Gazzaruso, C
   Solerte, SB
   De Amici, E
   Mancini, M
   Pujia, A
   Fratino, P
   Giustina, A
   Garzaniti, A
TI Association of the metabolic syndrome and insulin resistance with silent
   myocardial ischemia in patients with type 2 diabetes mellitus
SO AMERICAN JOURNAL OF CARDIOLOGY
LA English
DT Article
ID HOMEOSTASIS MODEL ASSESSMENT; CORONARY-ARTERY-DISEASE;
   HEART-RATE-VARIABILITY; CARDIOVASCULAR-DISEASE; LIPOPROTEIN(A);
   DYSFUNCTION; PREVALENCE; GLUCOSE
AB Metabolic syndrome is associated with elevated morbidity and mortality for overt coronary artery disease (CAD). In diabetic patients, CAD is often silent. The relation between metabolic syndrome and silent CAD has never been studied. We investigated whether metabolic syndrome is associated with silent CAD in patients with type 2 diabetes mellitus. We evaluated the prevalence of metabolic syndrome in 169 patients with uncomplicated diabetes and angiographically verified silent CAD and in 158 diabetic patients without myocardial ischemia on exercise electrocardiography, 48-hours ambulatory electrocardiography, and stress echocardiography. The groups were comparable for gender, age, glycemic control, and diabetes duration. Metabolic syndrome was defined according to the National Cholesterol Education Program criteria. To estimate insulin resistance in patients treated with diet alone or oral agents (122 patients with CAD and 115 patients without CAD), the Homeostasis Model Insulin-Resistance Assessment (HOMA) was used. The prevalence of metabolic syndrome (59.8% vs 44.3%, p = 0.005) and HOMA (5.4 +/- 2.1 vs 4.9 +/- 2.8, p = 0.044) were significantly higher in those with CAD than in those without CAD. Multiple logistic regression analysis showed that the metabolic syndrome was associated with silent CAD (odds ratio 2.44, 95% confidence interval 1.19 to 5.02, p = 0.015). Among patients on diet alone or oral agents, the HOMA was the strongest predictor of silent CAD (odds ratio 10.16, 95% confidence interval 2.60 to 39.63, p <0.001). In conclusion, our data have shown an independent association of metabolic syndrome and insulin resistance with silent CAD in patients with type 2 diabetes mellitus. Other studies are needed to establish whether metabolic syndrome and HOMA are reliable markers to identify diabetic patients for additional screening for silent CAD. (C) 2006 Elsevier Inc. All rights reserved.
C1 Maugeri Fdn Hosp, IRCCS, Pavia, Italy.
   Univ Pavia, Dept Internal Med & Med Therapeut, I-27100 Pavia, Italy.
   Univ Catanzaro, Dept Clin & Expt Med, Catanzaro, Italy.
   Azienda Sanit Locale, Pavia, Italy.
   Univ Brescia, Dept Internal Med, Brescia, Italy.
   Ctr Diabet, Pavia, Italy.
C3 Istituti Clinici Scientifici Maugeri IRCCS; University of Pavia;
   University of Pavia; Magna Graecia University of Catanzaro; University
   of Brescia
RP Maugeri Fdn Hosp, IRCCS, Pavia, Italy.
EM c.gazzaruso@tele2.it
RI Giustina, Andrea/AAN-5938-2020; Gazzaruso, Carmine/F-9072-2018
OI Pujia, Arturo/0000-0003-0763-4930; Gazzaruso,
   Carmine/0000-0001-9974-0735
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NR 17
TC 35
Z9 42
U1 0
U2 0
PU EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
PI BRIDGEWATER
PA 685 ROUTE 202-206 STE 3, BRIDGEWATER, NJ 08807 USA
SN 0002-9149
EI 1879-1913
J9 AM J CARDIOL
JI Am. J. Cardiol.
PD JAN 15
PY 2006
VL 97
IS 2
BP 236
EP 239
DI 10.1016/j.amjcard.2005.07.133
PG 4
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 005VC
UT WOS:000234851100016
PM 16442369
DA 2025-06-11
ER

PT J
AU Guichard, C
   Moreau, R
   Pessayre, D
   Epperson, TK
   Krause, KH
AF Guichard, Cecile
   Moreau, Richard
   Pessayre, Dominique
   Epperson, Terry Kay
   Krause, Karl-Heinz
TI NOX family NADPH oxidases in liver and in pancreatic islets: a role in
   the metabolic syndrome and diabetes?
SO BIOCHEMICAL SOCIETY TRANSACTIONS
LA English
DT Article; Proceedings Paper
CT 3rd Intracellular Proteolysis Meeting
CY MAR 05-07, 2008
CL Canary Isl, SPAIN
SP Joint Biochem Soc, INPROTEOLYS Network
DE diabetes; liver; metabolic Syndrome; NADPH oxidase; NOX family;
   pancreatic islet
ID HEPATIC STELLATE CELLS; ENDOPLASMIC-RETICULUM STRESS; UNFOLDED PROTEIN
   RESPONSE; ENZYME GENE-EXPRESSION; OXIDATIVE STRESS; BETA-CELL; NAD(P)H
   OXIDASE; INSULIN-RESISTANCE; MITOCHONDRIAL DYSFUNCTION; HEPATOCYTE
   APOPTOSIS
AB The incidence of obesity and non-esterified ('free') fatty acid-associated metabolic disorders such as the metabolic syndrome and diabetes is increasing dramatically in most countries. Although the pathogenesis of these metabolic disorders is complex, there is emerging evidence that ROS (reactive oxygen species) are critically involved in the aberrant signalling and tissue damage observed in this context. indeed, it is now widely accepted that ROS not only play an important role in physiology, but also contribute to cell and tissue dysfunction. inappropriate ROS generation may contribute to tissue dysfunction in two ways: (i) dysregulation of redox-sensitive signalling pathways, and (ii) oxidative damage to biological structures (DNA, proteins, lipids, etc.). An important source of ROS is the NOX family of NADPH oxidases. Several NOX isoforms are expressed in the liver and pancreatic beta-cells. There is now evidence that inappropriate activation of NOX enzymes may damage the liver and pancreatic beta-cells. in the context of the metabolic syndrome, the emerging epidemic of non-alcoholic steatohepatitis is thought to be NOX/ROS-dependent and of particular medical relevance. NOX/ROS-dependent beta-cell damage is thought to be involved in glucolipotoxicity and thereby leads to progression from the metabolic syndrome to Type 2 diabetes. Thus understanding the role of NOX enzymes in liver and beta-cell damage should lead to an increased understanding of pathomechanisms in the metabolic syndrome and diabetes and may identify useful targets for novel therapeutic strategies.
C1 [Guichard, Cecile; Pessayre, Dominique; Krause, Karl-Heinz] Geneva Med Fac, Dept Pathol & Immunol, CH-1211 Geneva 4, Switzerland.
   [Guichard, Cecile; Pessayre, Dominique; Krause, Karl-Heinz] Univ Hosp Geneva, CH-1211 Geneva 4, Switzerland.
   [Guichard, Cecile; Pessayre, Dominique; Krause, Karl-Heinz] Geneva Med Fac, Dept Genet, CH-1211 Geneva 4, Switzerland.
   [Guichard, Cecile; Pessayre, Dominique; Krause, Karl-Heinz] Geneva Med Fac, Lab Med, CH-1211 Geneva 4, Switzerland.
   [Guichard, Cecile; Moreau, Richard] Ctr Rech Biomed Bichat Beaujon CRB3, U773, INSERM, F-75870 Paris, France.
   [Pessayre, Dominique] Univ Beaujon, Grp Hosp, Serv Hepatol, F-92110 Clichy, France.
   [Epperson, Terry Kay] Univ Texas Hlth Sci Ctr San Antonio, Dept Med, San Antonio, TX 78229 USA.
   [Epperson, Terry Kay] S Texas Vet Hlth Care Syst, Audie L Murphy Div, San Antonio, TX 78229 USA.
C3 University of Geneva; University of Geneva; University of Geneva;
   University of Geneva; Institut National de la Sante et de la Recherche
   Medicale (Inserm); Universite Paris Cite; Assistance Publique Hopitaux
   Paris (APHP); Universite Paris Cite; Hopital Universitaire Beaujon -
   APHP; University of Texas System; University of Texas Health Science
   Center at San Antonio; US Department of Veterans Affairs; Veterans
   Health Administration (VHA); Audie L. Murphy Memorial Veterans Hospital
RP Krause, KH (corresponding author), Geneva Med Fac, Dept Pathol & Immunol, CH-1211 Geneva 4, Switzerland.
EM Karl-Heinz.Krause@medecine.unige.ch
RI Moreau, Richard/S-1300-2019; Krause, Karl-Heinz/E-8030-2011; Moreau,
   Richard/N-2197-2017
OI Moreau, Richard/0000-0003-0862-403X
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NR 86
TC 105
Z9 122
U1 0
U2 5
PU PORTLAND PRESS LTD
PI LONDON
PA CHARLES DARWIN HOUSE, 12 ROGER STREET, LONDON WC1N 2JU, ENGLAND
SN 0300-5127
EI 1470-8752
J9 BIOCHEM SOC T
JI Biochem. Soc. Trans.
PD OCT
PY 2008
VL 36
BP 920
EP 929
DI 10.1042/BST0360920
PN 5
PG 10
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Biochemistry & Molecular Biology
GA 360RW
UT WOS:000260076300027
PM 18793162
DA 2025-06-11
ER

PT J
AU Nie, GQ
   Wan, JJ
   Jiang, L
   Hou, SK
   Peng, W
AF Nie, Guqiao
   Wan, Jing Jing
   Jiang, Lei
   Hou, Shu Kai
   Peng, Wen
TI Correlation Analysis between Uric Acid and Metabolic Syndrome in the
   Chinese Elderly Population: A Cross-Sectional Study
SO INTERNATIONAL JOURNAL OF ENDOCRINOLOGY
LA English
DT Article
ID URATE HYDROPEROXIDE; OXIDATIVE STRESS; RISK; HYPERURICEMIA; RESISTANCE
AB Background. Currently, both metabolic syndrome and hyperuricaemia have attracted extensive attention in public health. The correlation between uric acid and metabolic syndrome is controversial. Research on the relationship between uric acid and metabolic syndrome in community-dwelling elderly people is relatively lacking. The purpose of this study is to explore the relationship between uric acid and metabolic syndrome in the community-dwelling elderly people. Design. Cross-sectional study. Methods. We collected the physical examination data of 1,267 elderly people in Gutian community in Wuhan and used SPSS IBM 25.0 for data analysis. Correlation and logistic regression analyses were performed, and ROC curves were drawn. Results. The uric acid level of the nonmetabolic syndrome group was lower than that of the metabolic syndrome group (337.31 vs. 381.91 mu mol/L; P < 0.05). Uric acid was positively correlated with systolic blood pressure (r = 0.177, P < 0.001), diastolic blood pressure (r = 0.135, P < 0.001), body mass index (r = 0.234, P < 0.001), waist circumference (r = 0.283, P < 0.001), and triglycerides (r = 0.217, P < 0.05). High-density lipoprotein cholesterol (r = -0.268, P < 0.001) showed the opposite trend. Logistic regression analysis results suggested that uric acid is a risk factor for metabolic syndrome. The result is described as exp (B) and 95% CI (1.003 [1.001, 1.005]). Based on the receiver operating characteristic curve, we found that the area under the curve of uric acid to diagnose metabolic syndrome was 0.64 (sensitivity: 79.3%, specificity: 45.1%). Conclusion. We observed an association between uric acid levels and metabolic syndrome in the elderly Chinese population. The best threshold value for uric acid in predicting metabolic syndrome diagnosis was 314.5 mu mol/l.
C1 [Nie, Guqiao; Wan, Jing Jing; Jiang, Lei; Peng, Wen] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Gen Practice, Wuhan, Peoples R China.
   [Hou, Shu Kai] Community Hlth Serv Ctr, Gutian St, Wuhan, Hubei, Peoples R China.
C3 Huazhong University of Science & Technology
RP Peng, W (corresponding author), Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Gen Practice, Wuhan, Peoples R China.
EM 313848396@qq.com; 8735174@qq.com; 13754412@qq.com; 179875107@qq.com;
   pengwen666@sina.com
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NR 35
TC 3
Z9 3
U1 2
U2 10
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1687-8337
EI 1687-8345
J9 INT J ENDOCRINOL
JI Int. J. Endocrinol.
PD JAN 17
PY 2023
VL 2023
AR 8080578
DI 10.1155/2023/8080578
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 8K8TZ
UT WOS:000923368600001
PM 36704419
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Kim, JH
   Im, JA
   Lee, DC
AF Kim, Jung-Ha
   Im, Jee-Aee
   Lee, Duk-Chul
TI The relationship between leukocyte mitochondrial DNA contents and
   metabolic syndrome in postmenopausal women
SO MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY
LA English
DT Article
DE Leukocyte mitochondrial DNA copy number; Mitochondrial dysfunction;
   Metabolic syndrome; Postmenopausal women
ID DEPENDENT DIABETES-MELLITUS; COPY NUMBER; INSULIN-RESISTANCE;
   PERIPHERAL-BLOOD; OXIDATIVE STRESS; SKELETAL-MUSCLE; HEALTHY WOMEN;
   RISK-FACTORS; US ADULTS; VITAMIN-D
AB Objective: Menopause is associated with increased risk of metabolic syndrome. There is growing evidence that mitochondrial dysfunction may lead to obesity and insulin resistance, which are major components of metabolic syndrome. The purpose of this study was to illuminate the relationship between mitochondrial function using leukocyte mitochondrial DNA copy number and metabolic syndrome in postmenopausal women.
   Methods: The present study included 144 postmenopausal women. Women with cardiovascular disease were excluded from the study sample. Anthropometric evaluation and biochemical tests were performed. Leukocyte mitochondrial DNA copy numbers were then measured.
   Results: The levels of leukocyte mitochondrial DNA copy number were lower among participants with metabolic syndrome than among those without metabolic syndrome (P < 0.01). As the number of components of metabolic syndrome increased, the concentration of leukocyte mitochondrial DNA copy number decreased (P = 0.02). Leukocyte mitochondrial DNA copy number was negatively correlated with waist circumference (r = -0.19, P = 0.03), fasting insulin (r = -0.19, P = 0.03), total cholesterol (r = -0.22, P < 0.01), and triglyceride (r = -0.37, P < 0.01). Leukocyte mitochondrial DNA copy number was positively associated with serum 25-hydroxyvitamin D levels (r = 0.94, P = <0.01). Multiple logistic regression analysis showed that leukocyte mitochondrial DNA copy number (odds ratio, 0.030; 95% CI, 0.002-0.437, P = 0.01) was independently associated with metabolic syndrome after adjustment for potential confounding variables including age, body mass index, homeostasis model assessment of insulin resistance, 25-hydroxyvitamin D, adiponectin, and high-sensitivity C-reactive protein.
   Conclusions: Leukocyte mitochondrial DNA copy number was independently associated with metabolic syndrome in postmenopausal women.
C1 [Lee, Duk-Chul] Yonsei Univ, Coll Med, Severance Hosp, Dept Family Med, Seoul 120752, South Korea.
   [Kim, Jung-Ha] Chung Ang Univ, Dept Family Med, Seoul 156756, South Korea.
   [Im, Jee-Aee] INTOTO Inc, Sports & Med Res Ctr, Seoul, South Korea.
C3 Yonsei University; Yonsei University Health System; Chung Ang University
RP Lee, DC (corresponding author), Yonsei Univ, Coll Med, Severance Hosp, Dept Family Med, 250 Seongsanno, Seoul 120752, South Korea.
EM faith@yuhs.ac
RI Kim, Eun-Ji/HHN-4611-2022
OI Lee, Duk Chul/0000-0001-9166-1813; , Jung-Ha/0000-0002-7630-9501
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NR 42
TC 26
Z9 29
U1 0
U2 10
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1072-3714
EI 1530-0374
J9 MENOPAUSE
JI Menopause-J. N. Am. Menopause Soc.
PD MAY
PY 2012
VL 19
IS 5
BP 582
EP 587
DI 10.1097/gme.0b013e31823a3e46
PG 6
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA 934AN
UT WOS:000303411200017
PM 22354267
DA 2025-06-11
ER

PT J
AU Williams, AD
   Shenassa, ED
AF Williams, Andrew D.
   Shenassa, Edmond D.
TI Sex-Specific Associations Between Area-Level Poverty and Cardiometabolic
   Dysfunction Among US Adolescents
SO PUBLIC HEALTH REPORTS
LA English
DT Article
DE poverty; adolescent health; cardiometabolic risk factors; socioeconomic
   status; environment
ID METABOLIC SYNDROME; CARDIOVASCULAR RISK; INCOME INEQUALITY; NEIGHBORHOOD
   DISADVANTAGE; CHILDHOOD; HEALTH; STRESS; ADULTHOOD; CHILDREN; OBESITY
AB Objective: Cardiometabolic disease is the leading cause of mortality in the United States. Cardiometabolic function during adolescence predicts future cardiometabolic disease, yet few studies have examined early determinants of cardiometabolic function. Informed by evidence of sex differences in the prevalence and severity of cardiometabolic disorders and evidence of sexual dimorphism in the stress response, we examined sex differences in the association between living in poverty and cardiometabolic function during adolescence, a precursor of later cardiometabolic disorders. Methods: We linked data from 10 415 adolescents aged 12-19 in the National Health and Nutrition Examination Survey (1999-2012) with US Census-tract data on area-level poverty (percentage of the population living in poverty, grouped into quartiles). We parameterized cardiometabolic dysfunction by summing the z scores of 6 cardiometabolic biomarkers, grouped into quintiles. Hierarchical ordinal models estimated associations. Results: Compared with residents in low-poverty areas, residents in high-poverty areas had elevated odds of cardiometabolic dysfunction (highest quartile of poverty odds ratio [OR] = 1.27; 95% confidence interval [CI], 1.08-1.50). This association was more pronounced among boys than girls (highest quartile of poverty for boys: OR = 1.36; 95% CI, 1.10-1.70; highest quartile of poverty for girls: OR = 1.17; 95% CI, 0.94-1.47). Conclusion: Our study supports the existence of sex-specific associations. These results highlight the potential for community-based programs, such as housing assistance, to improve population health.
C1 [Williams, Andrew D.; Shenassa, Edmond D.] Univ Maryland, Dept Family Sci, Maternal & Child Hlth Program, 4200 Valley Dr, College Pk, MD 20742 USA.
   [Shenassa, Edmond D.] Univ Maryland, Dept Epidemiol & Biostat, College Pk, MD 20742 USA.
   [Shenassa, Edmond D.] Brown Univ, Dept Epidemiol & Biostat, Sch Publ Hlth, Providence, RI 02912 USA.
   [Shenassa, Edmond D.] Univ Maryland, Sch Med, Dept Epidemiol & Biostat, Baltimore, MD 21201 USA.
C3 University System of Maryland; University of Maryland College Park;
   University System of Maryland; University of Maryland College Park;
   Brown University; University System of Maryland; University of Maryland
   Baltimore
RP Shenassa, ED (corresponding author), Univ Maryland, Dept Family Sci, Maternal & Child Hlth Program, 4200 Valley Dr, College Pk, MD 20742 USA.
EM shenassa@umd.edu
OI Shenassa, Edmond/0000-0001-6244-5847
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NR 52
TC 3
Z9 3
U1 1
U2 2
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0033-3549
EI 1468-2877
J9 PUBLIC HEALTH REP
JI Public Health Rep.
PD JAN
PY 2020
VL 135
IS 1
BP 47
EP 55
AR 0033354919884303
DI 10.1177/0033354919884303
EA NOV 2019
PG 9
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA JV7MG
UT WOS:000496686400001
PM 31725345
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Ghadge, AA
   Khaire, AA
   Kuvalekar, AA
AF Ghadge, Abhijit A.
   Khaire, Amrita A.
   Kuvalekar, Aniket A.
TI Adiponectin: A potential therapeutic target for metabolic syndrome
SO CYTOKINE & GROWTH FACTOR REVIEWS
LA English
DT Review
DE Adiponectin; Insulin resistance; Metabolic syndrome
ID ACTIVATED PROTEIN-KINASE; MOLECULAR-WEIGHT ADIPONECTIN;
   CORONARY-ARTERY-DISEASE; BODY-FAT DISTRIBUTION; LOW SERUM-LEVELS;
   INSULIN SENSITIVITY; PLASMA ADIPONECTIN; ETHNIC VARIATION; GLOBULAR
   DOMAIN; BINDING PROTEIN
AB Adiponectin is an important adipocytokine secreted chiefly by fat containing adipocytes, and plays a crucial role in glucose and lipid metabolism, inflammation and oxidative stress. Alterations in adiponectin levels have been shown to directly affect lipid and glucose metabolism that further increase the synthesis of lipids, free fatty acids and inflammatory cytokines. Changes in adiponectin levels also contribute to insulin resistance, obesity, cardiovascular diseases and type 2 diabetes. In the present review, we provide a comprehensive evaluation of the role of adiponectin and its molecular mechanisms in metabolic syndrome. Clinical improvement in adiponectin levels have been shown to positively modulate lipid and glucose metabolism, thus further substantiating its role in regulation of lipid and glucose metabolism. Currently adiponectin is being investigated as a potential therapeutic target for metabolic syndrome, although more research is required to understand the underlying mechanisms controlling adiponectin levels, including dietary and lifestyle interventions, that may target adiponectin as a therapeutic intervention in metabolic syndrome.
C1 [Ghadge, Abhijit A.; Kuvalekar, Aniket A.] Bharati Vidyapeeth Deemed Univ, IRSHA, Diabet Lab, Pune Satara Rd, Pune 411043, Maharashtra, India.
   [Khaire, Amrita A.] Bharati Vidyapeeth Deemed Univ, IRSHA, Dept Nutr Med, Pune Satara Rd, Pune 411043, Maharashtra, India.
C3 Bharati Vidyapeeth Deemed University; Bharati Vidyapeeth Deemed
   University
RP Kuvalekar, AA (corresponding author), Bharati Vidyapeeth Deemed Univ, IRSHA, Diabet Lab, Pune Satara Rd, Pune 411043, Maharashtra, India.
EM aniket.kuvalekar@bharatividyapeeth.edu
FU Bharati Vidyapeeth Deemed University
FX Authors are thankful to Bharati Vidyapeeth Deemed University for
   providing infrastructure facilities and financial support.
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NR 111
TC 126
Z9 141
U1 5
U2 45
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1359-6101
EI 1879-0305
J9 CYTOKINE GROWTH F R
JI Cytokine Growth Factor Rev.
PD FEB
PY 2018
VL 39
BP 151
EP 158
DI 10.1016/j.cytogfr.2018.01.004
PG 8
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA GD0IY
UT WOS:000430185700013
PM 29395659
DA 2025-06-11
ER

PT J
AU Rizvi, AA
AF Rizvi, Ali A.
TI Cytokine Biomarkers, Endothelial Inflammation, and Atherosclerosis in
   the Metabolic Syndrome: Emerging Concepts
SO AMERICAN JOURNAL OF THE MEDICAL SCIENCES
LA English
DT Review
DE Metabolic syndrome; Insulin resistance; Endothelial dysfunction;
   Atherosclerosis; Adipocytokines
ID C-REACTIVE PROTEIN; CORONARY-HEART-DISEASE; TUMOR-NECROSIS-FACTOR;
   LOW-GRADE INFLAMMATION; INSULIN-RESISTANCE; CARDIOVASCULAR-DISEASE;
   RISK-FACTORS; ADIPOSE-TISSUE; MYOCARDIAL-INFARCTION; DIABETES-MELLITUS
AB In recent years an explosion of research related to the cellular and vascular accompaniments of the metabolic syndrome has generated intense interest and controversy. Attention has focused on the vascular endothelium, where heightened, low-grade inflammatory processes lead to a continuum of vascular insults ranging from early endothelial derangements to advanced atherosclerosis. Inflammatory biocytokines, such as C-reactive protein, have been speculated to be both markers and mediators of oxidative stress and endovascular toxicity. Adipocytokines originating from fatty tissue have reinforced the concept that fat is a metabolically active organ rather than inert tissue. To fully elucidate its complex pathogenetic mechanisms, further inquiry into the inflammatory components of the metabolic syndrome is warranted. Unraveling the role of emerging proinflammatory markets has the promising potential to shed light into the underlying pathophysiology of the epidemic of obesity and the metabolic syndrome and thus help devise effective therapies.
C1 Univ S Carolina, Sch Med, Dept Med, Div Endocrinol Diabet & Metab, Columbia, SC 29203 USA.
C3 University of South Carolina System; University of South Carolina
   Columbia
RP Rizvi, AA (corresponding author), Univ S Carolina, Sch Med, Dept Med, Div Endocrinol Diabet & Metab, 2 Med Pk,Suite 306, Columbia, SC 29203 USA.
EM ali.rizvi@uscmed.sc.edu
RI Rizvi, Ali/AFV-2240-2022
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NR 92
TC 84
Z9 93
U1 0
U2 6
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0002-9629
EI 1538-2990
J9 AM J MED SCI
JI Am. J. Med. Sci.
PD OCT
PY 2009
VL 338
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BP 310
EP 318
DI 10.1097/MAJ.0b013e3181a4158c
PG 9
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 511OE
UT WOS:000271174300011
PM 19726972
DA 2025-06-11
ER

PT J
AU Weng-Yew, W
   Brown, L
AF Weng-Yew, Wong
   Brown, Lindsay
TI Nutrapharmacology of Tocotrienols for Metabolic Syndrome
SO CURRENT PHARMACEUTICAL DESIGN
LA English
DT Review
DE Metabolic syndrome; tocotrienols; tocopherols; diabetes; hypertension;
   atherosclerosis; adipogenesis
ID ISCHEMIA-REPERFUSION INJURY; ALPHA-TOCOPHERYL PHOSPHATE; VITAMIN-E;
   GAMMA-TOCOTRIENOL; ADIPOSE-TISSUE; CARDIOVASCULAR-DISEASE; PALM
   TOCOTRIENOLS; SIGNALING PATHWAY; OXIDATIVE STRESS; LIPID MEDIATORS
AB Metabolic syndrome is defined as a set of health risk factors that are associated with an increased chance of cardiovascular diseases and type 2 diabetes. These include abdominal obesity, hyperglycemia, impaired glucose tolerance, dyslipidemia, and hypertension. Interventions in metabolic syndrome include lifestyle interventions such as a healthy diet using functional foods together with increased physical activity to induce weight loss as the first aim of treatment. Nutraceuticals such as tocotrienols and tocopherols as members of the vitamin E family may be more targeted interventions. This review evaluates the effects of tocotrienols on the risk factors of metabolic syndrome using data from human, animal and in vitro studies. Tocotrienols improved lipid profiles and reduced atherosclerotic lesions, decreased blood glucose and glycated hemoglobin concentrations, normalized blood pressure, and inhibited adipogenesis. The differences in responses between tocopherols and tocotrienols in preventing obesity, diabetes, hypertension, artherosclerosis, ischemia, and inflammation suggest that different receptors or signaling mechanisms may be involved.
C1 [Brown, Lindsay] Univ So Queensland, Dept Biol & Phys Sci, Fac Sci, Toowoomba, Qld 4350, Australia.
   [Weng-Yew, Wong] Univ Queensland, Sch Biomed Sci, Brisbane, Qld 4072, Australia.
C3 University of Southern Queensland; University of Queensland
RP Brown, L (corresponding author), Univ So Queensland, Dept Biol & Phys Sci, Fac Sci, Toowoomba, Qld 4350, Australia.
EM Lindsay.Brown@usq.edu.au
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U2 25
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1381-6128
EI 1873-4286
J9 CURR PHARM DESIGN
JI Curr. Pharm. Design
PD JUL
PY 2011
VL 17
IS 21
BP 2206
EP 2214
DI 10.2174/138161211796957445
PG 9
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 883HI
UT WOS:000299624400008
PM 21774781
DA 2025-06-11
ER

PT J
AU Sotomayor, CG
   Minovic, I
   Eggersdorfer, ML
   Riphagen, IJ
   de Borst, MH
   Dekker, LH
   Nolte, IM
   Frank, J
   van Zon, SKR
   Reijneveld, SA
   van der Molen, JC
   Vos, MJ
   Kootstra-Ros, JE
   Rodrigo, R
   Kema, IP
   Navis, GJ
   Bakker, SJL
AF Sotomayor, Camilo G.
   Minovic, Isidor
   Eggersdorfer, Manfred L.
   Riphagen, Ineke J.
   de Borst, Martin H.
   Dekker, Louise H.
   Nolte, Ilja M.
   Frank, Jan
   van Zon, Sander K. R.
   Reijneveld, Sijmen A.
   van der Molen, Jan C.
   Vos, Michel J.
   Kootstra-Ros, Jenny E.
   Rodrigo, Ramon
   Kema, Ido P.
   Navis, Gerjan J.
   Bakker, Stephan J. L.
TI Duality of Tocopherol Isoforms and Novel Associations with Vitamins
   Involved in One-Carbon Metabolism: Results from an Elderly Sample of the
   LifeLines Cohort Study
SO NUTRIENTS
LA English
DT Article
DE elderly; vitamin E; tocopherol; total lipids; insulin resistance
   syndrome; one-carbon metabolism; pyridoxal phosphate; cobalamin; folate;
   homocysteine
ID TANDEM MASS-SPECTROMETRY; DIETARY ALPHA-TOCOPHEROL; BONE-MINERAL
   DENSITY; OXIDATIVE STRESS; GAMMA-TOCOPHEROL; ENDOTHELIAL DYSFUNCTION;
   INSULIN-RESISTANCE; SERUM; PLASMA; LIVER
AB Whether the affinity of serum vitamin E with total lipids hampers the appropriate assessment of its association with age-related risk factors has not been investigated in epidemiological studies. We aimed to compare linear regression-derived coefficients of the association of non-indexed and total lipids-indexed vitamin E isoforms with clinical and laboratory characteristics pertaining to the lipid, metabolic syndrome, and one-carbon metabolism biological domains. We studied 1429 elderly subjects (non-vitamin supplement users, 60-75 years old, with low and high socioeconomic status) from the population-based LifeLines Cohort and Biobank Study. We found that the associations of tocopherol isoforms with lipids were inverted in total lipids-indexed analyses, which may be indicative of overcorrection. Irrespective of the methods of standardization, we consistently found positive associations of alpha-tocopherol with vitamins of the one-carbon metabolism pathway and inverse associations with characteristics related to glucose metabolism. The associations of gamma-tocopherol were often opposite to those of alpha-tocopherol. These data suggest that tocopherol isoforms and one-carbon metabolism are related, with beneficial and adverse associations for alpha-tocopherol and gamma-tocopherol, respectively. Whether tocopherol isoforms, or their interplay, truly affect the one-carbon metabolism pathway remains to be further studied.
C1 [Sotomayor, Camilo G.; Eggersdorfer, Manfred L.; de Borst, Martin H.; Dekker, Louise H.; Navis, Gerjan J.; Bakker, Stephan J. L.] Univ Groningen, Univ Med Ctr Groningen, Dept Internal Med, NL-9700 RB Groningen, Netherlands.
   [Minovic, Isidor; Riphagen, Ineke J.; van der Molen, Jan C.; Vos, Michel J.; Kootstra-Ros, Jenny E.; Kema, Ido P.] Univ Groningen, Univ Med Ctr Groningen, Dept Lab Med, NL-9700 RB Groningen, Netherlands.
   [Nolte, Ilja M.] Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, NL-9700 RB Groningen, Netherlands.
   [Frank, Jan] Univ Hohenheim, Inst Nutr Sci, D-70599 Stuttgart, Germany.
   [van Zon, Sander K. R.; Reijneveld, Sijmen A.] Univ Groningen, Univ Med Ctr Groningen, Dept Hlth Sci, NL-9700 RB Groningen, Netherlands.
   [Rodrigo, Ramon] Univ Chile, Inst Biomed Sci, Fac Med, Mol & Clin Pharmacol Program, Santiago 8380453, Chile.
C3 University of Groningen; University of Groningen; University of
   Groningen; University Hohenheim; University of Groningen; Universidad de
   Chile
RP Sotomayor, CG (corresponding author), Univ Groningen, Univ Med Ctr Groningen, Dept Internal Med, NL-9700 RB Groningen, Netherlands.
EM c.g.sotomayor.campos@umcg.nl; i.minovic@umcg.nl;
   m.l.eggersdorfer@umcg.nl; i.j.riphagen@umcg.nl; m.h.de.borst@umcg.nl;
   l.h.dekker@umcg.nl; i.m.nolte@umcg.nl; jan.frank@nutres.de;
   s.k.r.van.zon@umcg.nl; s.a.reijneveld@umcg.nl;
   j.c.van.der.molen@umcg.nl; m.j.vos01@umcg.nl; j.e.kootstra@umcg.nl;
   rrodrigo@med.uchile.cl; i.p.kema@umcg.nl; g.j.navis@umcg.nl;
   s.j.l.bakker@umcg.nl
RI Rodrigo, Ramon/IYS-4056-2023; van der Klauw, M./A-2138-2014; Bakker,
   Stephan/J-4023-2015; Sotomayor, Camilo G./AAH-9500-2019
OI De Borst, Martin/0000-0002-4127-8733; Bakker,
   Stephan/0000-0003-3356-6791; Rodrigo, Ramon/0000-0003-1724-571X;
   Sotomayor, Camilo G./0000-0001-6835-6386; Reijneveld,
   Sijmen/0000-0002-1206-7523
FU Fonds Economische Structuurversterking, Samenwerkingsverband Noord
   Nederland; Comision Nacional de Investigacion en Ciencia y Tecnologia
   (CONICYT) [F 72190118]
FX Funding by Fonds Economische Structuurversterking, Samenwerkingsverband
   Noord Nederland and Ruimtelijk Economisch Programma have made possible
   the performance of the LifeLines Biobank and Cohort Study. Comision
   Nacional de Investigacion en Ciencia y Tecnologia supports Camilo G.
   Sotomayor with a personal grant (CONICYT F 72190118). The funders were
   not involved in the design of the study, nor participated in collection
   of the data, nor were involved in the performance of the analyses,
   publishing decision, nor manuscript preparations.
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NR 45
TC 0
Z9 0
U1 0
U2 2
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD FEB
PY 2020
VL 12
IS 2
AR 580
DI 10.3390/nu12020580
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA KY3GF
UT WOS:000522458700307
PM 32102191
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Wu, YK
   Yeh, CF
   Ly, TW
   Hung, MS
AF Wu, Yen-Ku
   Yeh, Ching-Fang
   Ly, Tai Wei
   Hung, Ming-Shiu
TI A New Perspective of Cannabinoid 1 Receptor Antagonists: Approaches
   Toward Peripheral CB1R Blockers without Crossing the Blood-Brain Barrier
SO CURRENT TOPICS IN MEDICINAL CHEMISTRY
LA English
DT Review
DE Metabolic disorders; Cannabinoid 1 receptor; Peripheral antagonists;
   SR141716A
ID INVERSE AGONISTS SYNTHESIS; IN-SILICO PREDICTION; OBESE-PATIENTS;
   RIMONABANT; DISCOVERY; EFFICACY; DRUGS; MICE; PERMEATION; ADIPOSITY
AB Since Rimonabant was withdrawn in Europe in 2008 because of its substantial CNS risk factors including depression and anxiety, the development of anti-obesity drugs targeting CB1R in the brain has been suspended and/or terminated globally. Instead, developing peripherally restricted CB1R antagonists is actively pursued in the hope that not only could they eliminate any CNS adverse effects observed with Rimonabant, but also maintain therapeutic benefits in metabolic syndrome, including obesity, type 2 diabetes, and non-alcoholic fatty liver diseases. In this review, we summarized the most recent advances that have been made on this area, with particular emphasis on various synthetic approaches, whereby the increase in polarity, water solubility and polar surface area were centralized on, toward potential peripheral-acting CB1 antagonists.
C1 [Yeh, Ching-Fang; Hung, Ming-Shiu] Natl Hlth Res Inst, Div Biotechnol & Pharmaceut Res, Zhunan 35053, Miaoli County, Taiwan.
   [Wu, Yen-Ku] Univ Alberta, Dept Chem, Edmonton, AB T6G 2G2, Canada.
   [Ly, Tai Wei] Axikin Pharmaceut Inc, San Diego, CA 92121 USA.
C3 National Health Research Institutes - Taiwan; University of Alberta
RP Hung, MS (corresponding author), Natl Hlth Res Inst, Div Biotechnol & Pharmaceut Res, 35 Keyan Rd, Zhunan 35053, Miaoli County, Taiwan.
EM mhung@nhri.org.tw
RI Hung, Ming-Shiu/C-1375-2010
OI Wu, Yen-Ku/0000-0002-9269-7444
FU National Health Research Institutes; Axikin Pharmaceuticals, Inc.
FX We are grateful to the National Health Research Institutes and Axikin
   Pharmaceuticals, Inc. for financial support.
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NR 52
TC 23
Z9 24
U1 1
U2 17
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y26, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1568-0266
J9 CURR TOP MED CHEM
JI Curr. Top. Med. Chem.
PD JUN
PY 2011
VL 11
IS 12
BP 1421
EP 1429
DI 10.2174/156802611795860997
PG 9
WC Chemistry, Medicinal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 777PW
UT WOS:000291636800002
PM 21510837
DA 2025-06-11
ER

PT J
AU Park, JH
   Kho, MC
   Kim, HY
   Ahn, YM
   Lee, YJ
   Kang, DG
   Lee, HS
AF Park, Ji Hun
   Kho, Min Chul
   Kim, Hye Yoom
   Ahn, You Mee
   Lee, Yun Jung
   Kang, Dae Gill
   Lee, Ho Sub
TI Blackcurrant Suppresses Metabolic Syndrome Induced by High-Fructose Diet
   in Rats
SO EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Article
ID INSULIN-RESISTANCE; OXIDATIVE STRESS; RISK-FACTORS; DISEASE; MODEL
AB Increased fructose ingestion has been linked to obesity, hyperglycemia, dyslipidemia, and hypertension associated with metabolic syndrome. Blackcurrant (Ribes nigrum; BC) is a horticultural crop in Europe. To inducemetabolic syndrome, Sprague-Dawley rats were fed 60% high-fructose diet. Treatment with BC (100 or 300mg/kg/day for 8 weeks) significantly suppressed increased liver weight, epididymal fatweight, C-reactive protein (CRP), total bilirubin, leptin, and insulin in rats with induced metabolic syndrome. BC markedly prevented increased adipocyte size and hepatic triglyceride accumulation in rats with induced metabolic syndrome. BC suppressed oral glucose tolerance and protein expression of insulin receptor substrate-1 (IRS-1) and phosphorylated AMP-activated protein kinase (p-AMPK) in muscle. BC significantly suppressed plasma total cholesterol, triglyceride, and LDL content. BC suppressed endothelial dysfunction by inducing downregulation of endothelin-1 and adhesion molecules in the aorta. Vascular relaxation of thoracic aortic rings by sodium nitroprusside and acetylcholine was improved by BC. The present study provides evidence of the potential protective effect of BC against metabolic syndrome by demonstrating improvements in dyslipidemia, hypertension, insulin resistance, and obesity in vivo.
C1 [Park, Ji Hun; Kho, Min Chul; Kim, Hye Yoom; Ahn, You Mee; Lee, Yun Jung; Kang, Dae Gill; Lee, Ho Sub] Wonkwang Univ, Hanbang Body Fluid Res Ctr, Iksan 570749, Jeonbuk, South Korea.
   [Kho, Min Chul; Kim, Hye Yoom; Ahn, You Mee; Lee, Yun Jung; Kang, Dae Gill; Lee, Ho Sub] Wonkwang Univ, Coll Oriental Med, Iksan 570749, Jeonbuk, South Korea.
   [Kho, Min Chul; Kim, Hye Yoom; Ahn, You Mee; Lee, Yun Jung; Kang, Dae Gill; Lee, Ho Sub] Wonkwang Univ, Profess Grad Sch Oriental Med, Iksan 570749, Jeonbuk, South Korea.
   [Kang, Dae Gill; Lee, Ho Sub] Wonkwang Univ, Profess Grad Sch Oriental Med, BK Plus Team 21, Iksan 570749, Jeonbuk, South Korea.
C3 Wonkwang University; Wonkwang University; Wonkwang University; Wonkwang
   University
RP Lee, HS (corresponding author), Wonkwang Univ, Hanbang Body Fluid Res Ctr, Iksan 570749, Jeonbuk, South Korea.
EM host@wku.ac.kr
FU National Research Foundation of Korea (NRF) grant - Korea government
   (MSIP) [2008-0062484, NRF-2014R1A2A2A01005101]
FX This work was supported by the National Research Foundation of Korea
   (NRF) grant funded by the Korea government (MSIP) (2008-0062484)
   (NRF-2014R1A2A2A01005101).
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NR 28
TC 13
Z9 15
U1 0
U2 8
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1741-427X
EI 1741-4288
J9 EVID-BASED COMPL ALT
JI Evid.-based Complement Altern. Med.
PY 2015
VL 2015
AR 385976
DI 10.1155/2015/385976
PG 11
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA CT9IC
UT WOS:000363129500001
PM 26504474
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Beer, C
   Rae, F
   Semmler, A
   Voisey, J
AF Beer, Cristina
   Rae, Fiona
   Semmler, Annalese
   Voisey, Joanne
TI Biomarkers in the Diagnosis and Prediction of Medication Response in
   Depression and the Role of Nutraceuticals
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE depression; biomarkers; pharmacogenomics; nutraceuticals
ID PHARMACOGENETICS IMPLEMENTATION CONSORTIUM; TREATMENT-RESISTANT
   DEPRESSION; PRIMARY-CARE; MTHFR GENE; ANTIDEPRESSANT TREATMENT; C677T
   POLYMORPHISM; METABOLIC SYNDROME; MAJOR DEPRESSION; OXIDATIVE STRESS;
   CLINICAL-USE
AB Depression continues to be a significant and growing public health concern. In clinical practice, it involves a clinical diagnosis. There is currently no defined or agreed upon biomarker/s for depression that can be readily tested. A biomarker is defined as a biological indicator of normal physiological processes, pathogenic processes, or pharmacological responses to a therapeutic intervention that can be objectively measured and evaluated. Thus, as there is no such marker for depression, there is no objective measure of depression in clinical practice. The discovery of such a biomarker/s would greatly assist clinical practice and potentially lead to an earlier diagnosis of depression and therefore treatment. A biomarker for depression may also assist in determining response to medication. This is of particular importance as not all patients prescribed with medication will respond, which is referred to as medication resistance. The advent of pharmacogenomics in recent years holds promise to target treatment in depression, particularly in cases of medication resistance. The role of pharmacogenomics in routine depression management within clinical practice remains to be fully established. Equally so, the use of pharmaceutical grade nutrients known as nutraceuticals in the treatment of depression in the clinical practice setting is largely unknown, albeit frequently self-prescribed by patients. Whether nutraceuticals have a role in not only depression treatment but also in potentially modifying the biomarkers of depression has yet to be proven. The aim of this review is to highlight the potential biomarkers for the diagnosis, prediction, and medication response of depression.
C1 [Beer, Cristina; Rae, Fiona; Voisey, Joanne] Queensland Univ Technol, Fac Hlth, Ctr Genom & Personalised Hlth, Sch Biomed Sci, Kelvin Grove, Qld 4059, Australia.
   [Semmler, Annalese] Queensland Univ Technol, Fac Hlth, Sch Clin Sci, Kelvin Grove, Qld 4059, Australia.
C3 Queensland University of Technology (QUT); Queensland University of
   Technology (QUT)
RP Voisey, J (corresponding author), Queensland Univ Technol, Fac Hlth, Ctr Genom & Personalised Hlth, Sch Biomed Sci, Kelvin Grove, Qld 4059, Australia.
EM cristina.beer@hdr.qut.edu.au; f.rae@qut.edu.au;
   annalese.semmler@qut.edu.au; j.voisey@qut.edu.au
RI Voisey, Joanne/HTL-2238-2023
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NR 141
TC 1
Z9 1
U1 6
U2 14
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD JUL
PY 2024
VL 25
IS 14
AR 7992
DI 10.3390/ijms25147992
PG 16
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA ZR5X6
UT WOS:001277045600001
PM 39063234
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Atar, D
   Malinin, A
   Pokov, A
   van Zyl, L
   Frasure-Smith, N
   Lesperance, F
   Serebruany, VL
AF Atar, Dan
   Malinin, Alex
   Pokov, Alex
   van Zyl, Louis
   Frasure-Smith, Nancy
   Lesperance, Francois
   Serebruany, Victor L.
TI Antiplatelet properties of Escitalopram in patients with the metabolic
   syndrome:: A dose-ranging In vitro study
SO NEUROPSYCHOPHARMACOLOGY
LA English
DT Article
DE selective serotonin reuptake inhibitors; escitalopram; depression;
   metabolic syndrome; platelets
ID DEPRESSIVE SYMPTOMS; PLATELET-FUNCTION; CORONARY EVENTS; YOUNG-ADULTS;
   INFLAMMATION; SERTRALINE; HEART; RISK; ASSOCIATION; ACTIVATION
AB There is an increasing body of evidence suggesting that selective serotonin reuptake inhibitors exhibit clinical benefit beyond treating depression, by simultaneously inhibiting platelet activity. We recently demonstrated that escitalopram (ESC), but not its major metabolites, inhibits multiple platelet biomarkers in healthy volunteers. Considering that the metabolic syndrome represents one of the major risk factors for vascular disease, we here determined how ESC affects platelet activity in such patients. We assessed the in vitro effects of preincubation with escalating (50-200 nM/l) concentrations of ESC on platelet aggregation, expression of major surface receptors by flow cytometry, and quantitatively by platelet function analyzers. Blood samples were obtained from 20 aspirin-naive patients with documented metabolic syndrome. Pretreatment of blood samples with medium ( 150 nM/l), or high (200 nM/l) doses of ESC resulted in a significant inhibition of platelet aggregation induced by ADP (p=0.007) and by collagen (p=0.004). Surface platelet expression of GPIb (CD42, p=0.03),LAMP-3 (CD63, p=0.04),and GP37 (CD165, p=0.03) was decreased in the ESC-pretreated samples. Closure time by the PFA-100 analyzer was prolonged after the 200 nM/l dose (p=0.02), indicating platelet inhibition under high shear conditions. On the other hand, the lowest tested concentration of ESC (50nM/l) did not affect platelet activity in these patients. The in vitro antiplatelet characteristics of ESC in patients with the metabolic syndrome are similar to those in healthy volunteers. However, higher ESC doses are required to induce equally potent platelet inhibition. These data justify prospective ex vivo studies with the highest therapeutic dose to determine the potential clinical advantage of ESC in high-risk patients with vascular disease.
C1 Aker Univ Hosp, Div Cardiol, Oslo, Norway.
   Univ Oslo, Fac Med, Oslo, Norway.
   Johns Hopkins Univ, HeartDrug Res LLC, Baltimore, MD USA.
   Queens Univ, Dept Psychiat, Kingston, ON K7L 3N6, Canada.
   McGill Univ, Dept Psychiat, Montreal, PQ, Canada.
   Univ Montreal, Dept Psychiat, Montreal, PQ H3C 3J7, Canada.
C3 University of Oslo; University of Oslo; Johns Hopkins University; Queens
   University - Canada; McGill University; Universite de Montreal
RP Serebruany, VL (corresponding author), Osler Med Ctr, HeartDurg Res Labs, 7600 Osler Dr,Suite 307, Towson, MD 21204 USA.
EM Heartdrug@aol.com
RI Atar, Dan/P-1419-2015; Goto, Shinya/AAU-6045-2020
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NR 37
TC 22
Z9 22
U1 0
U2 1
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0893-133X
EI 1740-634X
J9 NEUROPSYCHOPHARMACOL
JI Neuropsychopharmacology
PD NOV
PY 2007
VL 32
IS 11
BP 2369
EP 2374
DI 10.1038/sj.npp.1301355
PG 6
WC Neurosciences; Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA 221KL
UT WOS:000250226000013
PM 17356575
OA Bronze
DA 2025-06-11
ER

PT J
AU Kvandova, M
   Puzserova, A
   Balis, P
AF Kvandova, Miroslava
   Puzserova, Angelika
   Balis, Peter
TI Sexual Dimorphism in Cardiometabolic Diseases: The Role of AMPK
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE AMPK; sexual dimorphism; estrogen signaling; androgen signaling;
   endothelial function; metabolic regulation; cardiovascular diseases
ID ACTIVATED PROTEIN-KINASE; ESTROGEN-RECEPTOR-ALPHA; ENDOTHELIAL
   DYSFUNCTION; NITRIC-OXIDE; INSULIN-RESISTANCE; OXIDATIVE STRESS;
   GLUCOSE-UPTAKE; 5-AMINOIMIDAZOLE-4-CARBOXAMIDE RIBONUCLEOSIDE;
   CARDIOVASCULAR-DISEASES; GENDER-DIFFERENCES
AB Cardiovascular diseases (CVDs) are the leading cause of mortality and disability among both males and females. The risk of cardiovascular diseases is heightened by the presence of a risk factor cluster of metabolic syndrome, covering obesity and obesity-related cardiometabolic risk factors such as hypertension, glucose, and lipid metabolism dysregulation primarily. Sex hormones contribute to metabolic regulation and make women and men susceptible to obesity development in a different manner, which necessitates sex-specific management. Identifying crucial factors that protect the cardiovascular system is essential to enhance primary and secondary prevention of cardiovascular diseases and should be explicitly studied from the perspective of sex differences. It seems that AMP-dependent protein kinase (AMPK) may be such a factor since it has the protective role of AMPK in the cardiovascular system, has anti-diabetic properties, and is regulated by sex hormones. Those findings highlight the potential cardiometabolic benefits of AMPK, making it an essential factor to consider. Here, we review information about the cross-talk between AMPK and sex hormones as a critical point in cardiometabolic disease development and progression and a target for therapeutic intervention in human disease.
C1 [Kvandova, Miroslava; Puzserova, Angelika; Balis, Peter] Slovak Acad Sci, Inst Normal & Pathol Physiol, Ctr Expt Med, Bratislava 84104, Slovakia.
C3 Slovak Academy of Sciences; Institute of Normal & Pathological
   Physiology, SAS; Centre of Experimental Medicine, SAS
RP Kvandova, M (corresponding author), Slovak Acad Sci, Inst Normal & Pathol Physiol, Ctr Expt Med, Bratislava 84104, Slovakia.
EM miroslava.kvandova@savba.sk; angelika.puzserova@savba.sk;
   peter.balis@savba.sk
RI Puzserova, Angelika/W-1905-2018; Bališ, Peter/AAS-3538-2021
OI Kvandova, Miroslava/0000-0002-7741-8283; Puzserova,
   Angelika/0000-0001-7282-6547
FU H2020 Marie Sklodowska-Curie Actions [945478 (SASPRO2 1368/03/02)];
   Vedecka Grantova Agentura MSVVaS SR a SAV [APVV-22-0154]; Agentura na
   Podporu Vyskumu a Vyvoja [2/0153/21]
FX This research was funded by H2020 Marie Sklodowska-Curie Actions, grant
   agreement No 945478 (SASPRO2 1368/03/02) (M.K.); Agentura na Podporu
   Vyskumu a Vyvoja, grant agreement No APVV-22-0154 (M.K.), and Vedecka
   Grantova Agentura MSVVaS SR a SAV, grant agreement No 2/0153/21 (P.B.).
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NR 178
TC 4
Z9 4
U1 0
U2 1
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD AUG
PY 2023
VL 24
IS 15
AR 11986
DI 10.3390/ijms241511986
PG 27
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA O8MR6
UT WOS:001046302900001
PM 37569362
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Maury, E
   Ramsey, KM
   Bass, J
AF Maury, Eleonore
   Ramsey, Kathryn Moynihan
   Bass, Joseph
TI Circadian Rhythms and Metabolic Syndrome From Experimental Genetics to
   Human Disease
SO CIRCULATION RESEARCH
LA English
DT Review
DE clock; circadian; metabolic syndrome
ID REV-ERB-ALPHA; ENDOPLASMIC-RETICULUM STRESS; BROWN ADIPOSE-TISSUE;
   HIGH-FAT DIET; PLASMINOGEN-ACTIVATOR INHIBITOR-1; DORSOMEDIAL
   HYPOTHALAMIC NUCLEUS; BILE-ACID SYNTHESIS; DIURNAL-VARIATION; CLOCK
   GENES; GLUCOSE-TOLERANCE
AB The incidence of the metabolic syndrome represents a spectrum of disorders that continue to increase across the industrialized world. Both genetic and environmental factors contribute to metabolic syndrome and recent evidence has emerged to suggest that alterations in circadian systems and sleep participate in the pathogenesis of the disease. In this review, we highlight studies at the intersection of clinical medicine and experimental genetics that pinpoint how perturbations of the internal clock system, and sleep, constitute risk factors for disorders including obesity, diabetes mellitus, cardiovascular disease, thrombosis and even inflammation. An exciting aspect of the field has been the integration of behavioral and physiological approaches, and the emerging insight into both neural and peripheral tissues in disease pathogenesis. Consideration of the cell and molecular links between disorders of circadian rhythms and sleep with metabolic syndrome has begun to open new opportunities for mechanism-based therapeutics. (Circ Res. 2010; 106: 447-462.)
C1 [Bass, Joseph] Northwestern Univ, Dept Med, Div Endocrinol Metab & Mol Med, Evanston, IL 60208 USA.
   Northwestern Univ, Dept Neurobiol & Physiol, Evanston, IL 60208 USA.
C3 Northwestern University; Northwestern University
RP Bass, J (corresponding author), Northwestern Univ, Dept Med, Div Endocrinol Metab & Mol Med, Pancoe ENH Pavil Room 4405,2200 Campus Dr, Evanston, IL 60208 USA.
EM j-bass@northwestern.edu
OI Maury, Eleonore/0000-0001-7517-1988
FU Alfediam; National Institute of Diabetes and Digestive and Kidney
   Diseases [T32 DK007169]; NIH [P01 AG011412, R01HL097817-01]; American
   Diabetes Association; Chicago Biomedical Consortium Searle Funds;
   Juvenile Diabetes Research Foundation; University of Chicago Diabetes
   Research and Training Center [P60 DK020595]
FX This work was supported by Alfediam (to E. M.), National Institute of
   Diabetes and Digestive and Kidney Diseases (T32 DK007169 to K. M. R.),
   NIH (P01 AG011412 and R01HL097817-01 to J.B.), American Diabetes
   Association (to J.B.), Chicago Biomedical Consortium Searle Funds (to
   J.B.), Juvenile Diabetes Research Foundation (to J.B.), and the
   University of Chicago Diabetes Research and Training Center (P60
   DK020595).
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NR 248
TC 371
Z9 421
U1 3
U2 68
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0009-7330
EI 1524-4571
J9 CIRC RES
JI Circ.Res.
PD FEB 19
PY 2010
VL 106
IS 3
BP 447
EP 462
DI 10.1161/CIRCRESAHA.109.208355
PG 16
WC Cardiac & Cardiovascular Systems; Hematology; Peripheral Vascular
   Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Hematology
GA 557EC
UT WOS:000274651400009
PM 20167942
OA Bronze, Green Accepted
DA 2025-06-11
ER

PT J
AU Hsieh, C
   Yen, YF
   Chen, CC
   Chou, YC
   Chen, MJ
AF Hsieh, Chen
   Yen, Yung-Feng
   Chen, Chu-Chieh
   Chou, Yi-Chang
   Chen, Mei-Ju
TI Impact of COVID-19 Pandemic on the Prevalence of Metabolic Syndrome in
   Health Care Workers
SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
LA English
DT Article
DE COVID-19 pandemic; metabolic syndrome; health care worker; central
   obesity; hypertension
ID OBESITY; ANXIETY
AB Objectives: This cohort study aimed to determine the effect of the COVID-19 pandemic on the prevalence of metabolic syndrome (MetS) among health care workers at a dedicated COVID-19 hospital in Taiwan. Methods: This study recruited 397 health care workers who completed health checkups before and during the COVID-19 pandemic. The differences of MetS and its components prevalence before and during the COVID-19 pandemic were compared using the paired samples t tests for normally distributed variables, and Wilcoxon signed-rank tests for nonnormally distributed variables. Results: The prevalence of MetS among health care workers significantly increased from 20.9% to 28.7% during the pandemic (P < 0.001). Central obesity and hypertension were the primary contributors to the development of MetS. Conclusions: COVID-19 pandemic was associated with an increasing prevalence of MetS in health care workers, necessitating health-promoting measures to mitigate this risk.
C1 [Hsieh, Chen; Chen, Mei-Ju] Taipei City Hosp, Dept Family Med, Heping Fuyou Branch, Taipei, Taiwan.
   [Yen, Yung-Feng] Taipei City Hosp, Heping Fuyou Branch, Sect Infect Dis, Taipei, Taiwan.
   [Yen, Yung-Feng; Chen, Chu-Chieh; Chen, Mei-Ju] Natl Taipei Univ Nursing & Hlth Sci, Dept Hlth Care Management, Taipei, Taiwan.
   [Yen, Yung-Feng; Chen, Mei-Ju] Taipei Med Univ, Coll Med, Sch Med, Dept Radiol, Taipei, Taiwan.
   [Yen, Yung-Feng; Chou, Yi-Chang] Natl Yang Ming Chiao Tung Univ, Inst Publ Hlth, Taipei, Taiwan.
   [Yen, Yung-Feng; Chou, Yi-Chang] Univ Taipei, Taipei, Taiwan.
   [Yen, Yung-Feng; Chou, Yi-Chang] Taipei City Hosp, Dept Educ & Res, Taipei, Taiwan.
C3 Taipei City Hospital; Taipei City Hospital; National Taipei University
   of Nursing & Health Science (NTUNHS); Taipei Medical University;
   National Yang Ming Chiao Tung University; University of Taipei; Taipei
   City Hospital
RP Chen, MJ (corresponding author), 33,Sec 2,Zhonghua Rd, Taipei 100058, Taiwan.
EM hsiehchen91@gmail.com; yfyen1@gmail.com; chuje@ntunhs.edu.tw;
   T0036@tpech.gov.tw; DXD41@tpech.gov.tw
RI Yen, Yung-Feng/JYP-3010-2024
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NR 38
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1076-2752
EI 1536-5948
J9 J OCCUP ENVIRON MED
JI J. Occup. Environ. Med.
PD JAN
PY 2025
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DI 10.1097/JOM.0000000000003255
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WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA R1F9V
UT WOS:001389009300004
PM 39419007
DA 2025-06-11
ER

PT J
AU Canale, MP
   di Villahermosa, SM
   Martino, G
   Rovella, V
   Noce, A
   De Lorenzo, A
   Di Daniele, N
AF Canale, Maria Paola
   di Villahermosa, Simone Manca
   Martino, Giuliana
   Rovella, Valentina
   Noce, Annalisa
   De Lorenzo, Antonino
   Di Daniele, Nicola
TI Obesity-Related Metabolic Syndrome: Mechanisms of Sympathetic
   Overactivity
SO INTERNATIONAL JOURNAL OF ENDOCRINOLOGY
LA English
DT Review
ID INDUCED INSULIN-RESISTANCE; NERVOUS-SYSTEM ACTIVITY; DIETARY
   WEIGHT-LOSS; FREE FATTY-ACID; BLOOD-PRESSURE; OXIDATIVE STRESS;
   NITRIC-OXIDE; RENAL DENERVATION; ARCUATE NUCLEUS; ADIPOSE-TISSUE
AB The prevalence of the metabolic syndrome has increased worldwide over the past few years. Sympathetic nervous system overactivity is a key mechanism leading to hypertension in patients with the metabolic syndrome. Sympathetic activation can be triggered by reflex mechanisms as arterial baroreceptor impairment, by metabolic factors as insulin resistance, and by dysregulated adipokine production and secretion from visceral fat with a mainly permissive role of leptin and antagonist role of adiponectin. Chronic sympathetic nervous system overactivity contributes to a further decline of insulin sensitivity and creates a vicious circle that may contribute to the development of hypertension and of the metabolic syndrome and favor cardiovascular and kidney disease. Selective renal denervation is an emerging area of interest in the clinical management of obesity-related hypertension. This review focuses on current understanding of some mechanisms through which sympathetic overactivity may be interlaced to the metabolic syndrome, with particular regard to the role of insulin resistance and of some adipokines.
C1 [Canale, Maria Paola; di Villahermosa, Simone Manca; Martino, Giuliana; Rovella, Valentina; Noce, Annalisa; Di Daniele, Nicola] Univ Roma Tor Vergata, Dept Syst Med, Div Nephrol & Hypertens, Rome, Italy.
   [De Lorenzo, Antonino] Univ Roma Tor Vergata, Div Clin Nutr & Nutrigen, Dept Biomed & Prevent, Rome, Italy.
C3 University of Rome Tor Vergata; University of Rome Tor Vergata
RP Di Daniele, N (corresponding author), Univ Roma Tor Vergata, Dept Syst Med, Div Nephrol & Hypertens, Rome, Italy.
EM didaniele@med.uniroma2.it
RI Rovella, Valentina/AAB-9727-2019; Noce, Annalisa/B-5558-2019;
   Stefanadis, Christodoulos/ABH-2232-2020
OI Stefanadis, Christodoulos/0000-0001-5974-6454; Rovella,
   Valentina/0000-0002-3311-486X; NOCE, ANNALISA/0000-0003-1310-3730; De
   Lorenzo, Antonino/0000-0001-6524-4493
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NR 153
TC 154
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PU HINDAWI LTD
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PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
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EI 1687-8345
J9 INT J ENDOCRINOL
JI Int. J. Endocrinol.
PY 2013
VL 2013
AR 865965
DI 10.1155/2013/865965
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 249BU
UT WOS:000326752500001
PM 24288531
OA Green Submitted, Green Published, Green Accepted, gold
DA 2025-06-11
ER

PT J
AU El-Atat, FA
   Stas, SN
   McFarlane, SI
   Sowers, JR
AF El-Atat, FA
   Stas, SN
   McFarlane, SI
   Sowers, JR
TI The relationship between hyperinsulinemia, hypertension and progressive
   renal disease
SO JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
LA English
DT Article
ID CONVERTING-ENZYME-INHIBITION; NUTRITION EXAMINATION SURVEY;
   INSULIN-RESISTANCE SYNDROME; ATRIAL-NATRIURETIC-PEPTIDE; NERVOUS-SYSTEM
   ACTIVITY; LOWERS BLOOD-PRESSURE; 3RD NATIONAL-HEALTH; METABOLIC
   SYNDROME; DIABETES-MELLITUS; CARDIOVASCULAR-DISEASE
AB The incidence of end-stage renal disease (ESRD) has risen dramatically in the past decade, mainly due to the increasing prevalence of diabetes mellitus, and both impaired glucose tolerance and hypertension are important contributors to rising rates of ESRD. Obesity, especially the visceral type, is associated with peripheral resistance to insulin actions and hyperinsulinemia, which predisposes to development of diabetes. A common genetic predisposition to insulin resistance and hypertension and the coexistence of these two disorders predisposes to premature atherosclerosis. A constellation of metabolic and cardiovascular derangements, which also includes dyslipidemia, dysglycemia, endothelial dysfunction, fibrinolytic and inflammatory abnormalities, left ventricular hypertrophy, microalbuminuria, and increased oxidative stress, is referred to as the cardiometabolic syndrome. The components of this syndrome, individually and interdependently, substantially increase the risk of renal disease, cardiovascular disease (CVD) and mortality. Similar findings and cardiorenal risk factors can occur in subjects with android obesity without excess body weight.
   Recently, microalbuminuria has been gaining momentum as a component and marker for the cardiometabolic syndrome, in addition to being an early marker for progressive renal disease in patients with this syndrome or in those with diabetes. Furthermore, it is now established as an independent predictor of CVD and CVD mortality. This review examines the relationship between insulin resistance/hyperinsulinemia and hypertension in the context of cardiometabolic syndrome, progressive renal disease and accelerated CVD. The importance of microalbuminuria as an early marker for the cardiometabolic syndrome is also discussed in this review.
C1 Univ Missouri, Dept Internal Med, Hlth Sci Ctr, Columbia, MO 65212 USA.
   HS Truman VAMC, Dept Internal Med, Columbia, MO USA.
   SUNY Hlth Sci Ctr, Dept Med, Div Cardiovasc Med & Endocrinol, Brooklyn, NY 11203 USA.
   SUNY Hlth Sci Ctr, Dept Med, Div Diabet & & Hypertens, Brooklyn, NY 11203 USA.
   Vet Adm Med Ctr, Brooklyn, NY 11209 USA.
C3 University of Missouri System; University of Missouri Columbia;
   University of Missouri System; University of Missouri Columbia; US
   Department of Veterans Affairs; Veterans Health Administration (VHA);
   Harry S. Truman Memorial Veterans' Hospital; State University of New
   York (SUNY) System; SUNY Downstate Health Sciences University; State
   University of New York (SUNY) System; SUNY Downstate Health Sciences
   University; US Department of Veterans Affairs; Veterans Health
   Administration (VHA)
RP Univ Missouri, Dept Internal Med, Hlth Sci Ctr, MA410,1 Hosp Dr, Columbia, MO 65212 USA.
EM Sowersj@health.missouri.edu
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NR 60
TC 138
Z9 158
U1 0
U2 5
PU AMER SOC NEPHROLOGY
PI WASHINGTON
PA 1725 I ST, NW STE 510, WASHINGTON, DC 20006 USA
SN 1046-6673
EI 1533-3450
J9 J AM SOC NEPHROL
JI J. Am. Soc. Nephrol.
PD NOV
PY 2004
VL 15
IS 11
BP 2816
EP 2827
DI 10.1097/01.ASN.0000133698.80390.37
PG 12
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 865EB
UT WOS:000224684200006
PM 15504934
OA Bronze
DA 2025-06-11
ER

PT J
AU Gallardo-Alfaro, L
   Bibiloni, MDM
   Mascaró, CM
   Montemayor, S
   Ruiz-Canela, M
   Salas-Salvadó, J
   Corella, D
   Fitó, M
   Romaguera, D
   Vioque, J
   Alonso-Gómez, AM
   Wärnberg, J
   Martínez, JA
   Serra-Majem, L
   Estruch, R
   Fernández-García, JC
   Lapetra, J
   Pintó, X
   García Ríos, A
   Bueno-Cavanillas, A
   Gaforio, JJ
   Matía-Martín, P
   Daimiel, L
   Micó-Pérez, RM
   Vidal, J
   Vázquez, C
   Ros, E
   Fernandez-Lázaro, CI
   Becerra-Tomás, N
   Gimenez-Alba, IM
   Zomeño, MD
   Konieczna, J
   Compañ-Gabucio, L
   Tojal-Sierra, L
   Pérez-López, J
   Zulet, MA
   Casañas-Quintana, T
   Castro-Barquero, S
   Gómez-Pérez, AM
   Santos-Lozano, JM
   Galera, A
   Basterra-Gortari, FJ
   Basora, J
   Saiz, C
   Pérez-Vega, KA
   Galmés-Panadés, AM
   Tercero-Maciá, C
   Sorto-Sánchez, C
   Sayón-Orea, C
   García-Gavilán, J
   Muñoz-Martínez, J
   Tur, JA
AF Gallardo-Alfaro, Laura
   del Mar Bibiloni, Maria
   Mascaro, Catalina M.
   Montemayor, Sofia
   Ruiz-Canela, Miguel
   Salas-Salvado, Jordi
   Corella, Dolores
   Fito, Montserrat
   Romaguera, Dora
   Vioque, Jesus
   Alonso-Gomez, Angel M.
   Warnberg, Julia
   Alfredo Martinez, J.
   Serra-Majem, Lluis
   Estruch, Ramon
   Carlos Fernandez-Garcia, Jose
   Lapetra, Jose
   Pinto, Xavier
   Garcia Rios, Antonio
   Bueno-Cavanillas, Aurora
   Gaforio, Jose J.
   Matia-Martin, Pilar
   Daimiel, Lidia
   Mico-Perez, Rafael M.
   Vidal, Josep
   Vazquez, Clotilde
   Ros, Emilio
   Ignacio Fernandez-Lazaro, Cesar
   Becerra-Tomas, Nerea
   Manuel Gimenez-Alba, Ignacio
   Zomeno, Maria Dolors
   Konieczna, Jadwiga
   Compan-Gabucio, Laura
   Tojal-Sierra, Lucas
   Perez-Lopez, Jessica
   Angeles Zulet, M.
   Casanas-Quintana, Tamara
   Castro-Barquero, Sara
   Maria Gomez-Perez, Ana
   Manuel Santos-Lozano, Jose
   Galera, Ana
   Javier Basterra-Gortari, F.
   Basora, Josep
   Saiz, Carmen
   Alejandra Perez-Vega, Karla
   Galmes-Panades, Aina M.
   Tercero-Macia, Cristina
   Sorto-Sanchez, Carolina
   Sayon-Orea, Carmen
   Garcia-Gavilan, Jesus
   Munoz-Martinez, Julia
   Tur, Josep A.
CA PREDIMED-Plus Investigators
TI Leisure-Time Physical Activity, Sedentary Behaviour and Diet Quality are
   Associated with Metabolic Syndrome Severity: The PREDIMED-Plus Study
SO NUTRIENTS
LA English
DT Article
DE metabolic syndrome severity; physical activity; Mediterranean diet;
   depression risk; sedentary behaviour
ID CARDIOVASCULAR RISK; ALL-CAUSE; MORTALITY; METAANALYSIS; PREVALENCE;
   OBESITY; ADULTS; CONSUMPTION; DISEASES; SMOKING
AB Healthy lifestyle factors, such as physical activity (PA) and Mediterranean diet (MD), decrease the likelihood of developing metabolic syndrome (MetS). The aim of this study was to report main lifestyle components and related factors according to the MetS severity. Cross-sectional analysis was done of baseline lifestyle factors from 5739 participants with overweight/obesity and MetS features (aged 55-75 years) included in the PREDIMED-PLUS primary cardiovascular prevention randomized trial. Participants were categorized in tertiles according to a validated MetS severity score (MetSSS). Anthropometrics, visceral adiposity index, dietary nutrient intake, biochemical marker levels, as well as a Dietary Inflammatory Index and depression symptoms (Beck Depression Inventory-II) were measured. Diet quality was assessed using a 17-item energy-restricted MD questionnaire. Duration and intensity of PA was self-reported using the Minnesota-REGICOR Short Physical Activity Questionnaire. Sedentary behaviours were measured using the Spanish version of the Nurses' Health Study questionnaire. The 30 s chair stand test was also assessed. Participants with highest MetSSS showed higher values of cardiovascular risk factors (except for total cholesterol and LDL cholesterol), depression risk, sedentary and TV viewing time, and lower moderate and vigorous leisure-time physical activity (LTPA). Highest MetSSS participants tended to a pro-inflammatory dietary pattern and tended to lower MD adherence. In addition, they showed lower carbohydrate and nut intake and higher intake of protein, saturated and trans fatty acids, cholesterol, iodine, sodium, red and processed meat products, other oils different from olive oil and spirit alcoholic drinks. The highest MetS severity score was associated with lower moderate and vigorous LTPA and higher sedentary time and depression risk, as they tended to a pro-inflammatory dietary pattern and lower MD adherence.
C1 [Gallardo-Alfaro, Laura; del Mar Bibiloni, Maria; Mascaro, Catalina M.; Montemayor, Sofia; Ruiz-Canela, Miguel; Salas-Salvado, Jordi; Corella, Dolores; Fito, Montserrat; Romaguera, Dora; Alonso-Gomez, Angel M.; Warnberg, Julia; Alfredo Martinez, J.; Serra-Majem, Lluis; Estruch, Ramon; Carlos Fernandez-Garcia, Jose; Lapetra, Jose; Pinto, Xavier; Garcia Rios, Antonio; Vazquez, Clotilde; Ros, Emilio; Ignacio Fernandez-Lazaro, Cesar; Becerra-Tomas, Nerea; Manuel Gimenez-Alba, Ignacio; Zomeno, Maria Dolors; Konieczna, Jadwiga; Tojal-Sierra, Lucas; Perez-Lopez, Jessica; Angeles Zulet, M.; Casanas-Quintana, Tamara; Castro-Barquero, Sara; Maria Gomez-Perez, Ana; Manuel Santos-Lozano, Jose; Galera, Ana; Javier Basterra-Gortari, F.; Basora, Josep; Saiz, Carmen; Alejandra Perez-Vega, Karla; Galmes-Panades, Aina M.; Sorto-Sanchez, Carolina; Sayon-Orea, Carmen; Garcia-Gavilan, Jesus; Munoz-Martinez, Julia; Tur, Josep A.] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr CIBEROBN, Madrid 28029, Spain.
   [Gallardo-Alfaro, Laura; del Mar Bibiloni, Maria; Mascaro, Catalina M.; Montemayor, Sofia; Tur, Josep A.] Univ Balearic Isl, Res Grp Community Nutr & Oxidat Stress, Palma de Mallorca 07122, Spain.
   [Gallardo-Alfaro, Laura; del Mar Bibiloni, Maria; Mascaro, Catalina M.; Montemayor, Sofia; Romaguera, Dora; Konieczna, Jadwiga; Galmes-Panades, Aina M.; Tur, Josep A.] Hlth Res Inst Balear Isl IdISBa, Palma de Mallorca 07120, Spain.
   [Ruiz-Canela, Miguel; Ignacio Fernandez-Lazaro, Cesar; Javier Basterra-Gortari, F.; Sayon-Orea, Carmen] Univ Navarra, IdISNA, Dept Prevent Med & Publ Hlth, Pamplona 31008, Spain.
   [Salas-Salvado, Jordi; Becerra-Tomas, Nerea; Basora, Josep; Garcia-Gavilan, Jesus] Univ Rovira & Virgili, IISPV, Dept Biochem & Biotechnol, Human Nutr Unit, Reus 43201, Spain.
   [Corella, Dolores; Manuel Gimenez-Alba, Ignacio; Saiz, Carmen] Univ Valencia, Dept Prevent Med, Valencia 46100, Spain.
   [Fito, Montserrat; Zomeno, Maria Dolors; Alejandra Perez-Vega, Karla] Inst Hosp Mar Invest Med Municipal Invest Med IMI, Barcelona 08003, Spain.
   [Vioque, Jesus; Compan-Gabucio, Laura; Munoz-Martinez, Julia] Miguel Hernandez Univ, Nutr Epidemiol Unit, Inst Invest Sanitaria & Biomed Alicante ISABIAL, Alicante 46020, Spain.
   [Vioque, Jesus; Bueno-Cavanillas, Aurora; Gaforio, Jose J.; Compan-Gabucio, Laura] Inst Salud Carlos III, CIBER Epidemiol & Salud Publ CIBERESP, Madrid 28029, Spain.
   [Alonso-Gomez, Angel M.; Tojal-Sierra, Lucas; Sorto-Sanchez, Carolina] Univ Basque Country, Bioaraba Hlth Res Inst, Osakidetza Basque Hlth Serv, Araba Univ Hosp,UPV EHU, Vitoria 48013, Spain.
   [Warnberg, Julia; Perez-Lopez, Jessica] Univ Malaga, IBIMA, Sch Hlth Sci, Dept Nursing, Malaga 29071, Spain.
   [Alfredo Martinez, J.; Angeles Zulet, M.] CEI UAM CSIC, IMDEA Food, Precis Nutr Program, Madrid 28049, Spain.
   [Alfredo Martinez, J.] Univ Navarra, Ctr Nutr Res, Dept Nutr Food Sci & Physiol, Pamplona 31008, Spain.
   [Serra-Majem, Lluis; Casanas-Quintana, Tamara] Univ Las Palmas Gran Canaria, Inst Biomed Res, Las Palmas Gran Canaria 35016, Spain.
   [Estruch, Ramon] Univ Barcelona, Hosp Clin, IDIBAPS, Dept Internal Med, Barcelona 08036, Spain.
   [Carlos Fernandez-Garcia, Jose; Maria Gomez-Perez, Ana] Univ Malaga, Dept Endocrinol, Virgen Victoria Hosp, Malaga 29010, Spain.
   [Lapetra, Jose; Manuel Santos-Lozano, Jose] Distrito Sanitario Atenc Primaria Sevilla, Res Unit, Dept Family Med, Seville 41013, Spain.
   [Pinto, Xavier; Galera, Ana] Hosp Univ Bellvitge, Lipids & Vasc Risk Unit, Internal Med, Barcelona 08907, Spain.
   [Garcia Rios, Antonio] Univ Cordoba, Reina Sofia Univ Hosp, Maimonides Biomed Res Inst Cordoba IMIBIC, Lipids & Atherosclerosis Unit,Dept Internal Med, Cordoba 14004, Spain.
   [Bueno-Cavanillas, Aurora] Univ Granada, Dept Prevent Med, Granada 18071, Spain.
   [Gaforio, Jose J.] Univ Jaen, Dept Hlth Sci, Ctr Estudios Avanzados Olivar & Aceites Oliva, Jaen 23071, Spain.
   [Matia-Martin, Pilar] Inst Invest Sanitaria Hosp Clin San Carlos IdISSC, Dept Endocrinol & Nutr, Madrid 28040, Spain.
   [Daimiel, Lidia] CEI UAM CSIC, IMDEA Food, Nutr Genom & Epigenom Grp, Madrid 28049, Spain.
   [Mico-Perez, Rafael M.] Inst Salud Carlos III, CIBER Diabet & Enfermedades Metabol CIBERDEM, Madrid 28029, Spain.
   [Mico-Perez, Rafael M.] Network Researchers REDI Fdn SEMERGEN, Madrid 28009, Spain.
   [Vidal, Josep] Univ Barcelona, Hosp Clin, IDIBAPS, Dept Endocrinol, Barcelona 08036, Spain.
   [Vazquez, Clotilde] Fdn Jimenez Diaz, Dept Endocrinol, Madrid 28040, Spain.
   [Ros, Emilio] Hosp Clin Barcelona, Inst Invest Biomed August Pi Sunyer IDIBAPS, Dept Endocrinol & Nutr, Lipid Clin, Barcelona 08036, Spain.
   [Castro-Barquero, Sara] Univ Barcelona, Fac Med & Hlth Sci, Dept Med, Barcelona 08036, Spain.
   [Javier Basterra-Gortari, F.; Sayon-Orea, Carmen] Osasunbidea, Serv Navarro Salud, Pamplona 31071, Spain.
   [Tercero-Macia, Cristina] Ctr Salud Raval, Elche 03203, Spain.
C3 CIBER - Centro de Investigacion Biomedica en Red; CIBEROBN; Instituto de
   Salud Carlos III; Universitat de les Illes Balears; Institut
   Investigacio Sanitaria Illes Balears (IdISBa); University of Navarra;
   Universitat Rovira i Virgili; Institut d'Investigacio Sanitaria Pere
   Virgili (IISPV); University of Valencia; General University Hospital of
   Alicante; Universidad Miguel Hernandez de Elche; Universitat d'Alacant;
   Instituto de Investigacion Sanitaria y Biomedica de Alicante (ISABIAL);
   Instituto de Salud Carlos III; CIBER - Centro de Investigacion Biomedica
   en Red; CIBERESP; University of Basque Country; Bioaraba Health Research
   Institute; University Hospital of Araba; Universidad de Malaga;
   Instituto de Investigacion Biomedica de Malaga y Plataforma en
   Nanomedicina (IBIMA); Consejo Superior de Investigaciones Cientificas
   (CSIC); IMDEA Food Institute; University of Navarra; Universidad de Las
   Palmas de Gran Canaria; University of Barcelona; Hospital Clinic de
   Barcelona; IDIBAPS; Universidad de Malaga; Institut d'Investigacio
   Biomedica de Bellvitge (IDIBELL); Bellvitge University Hospital;
   University of Barcelona; Universidad de Cordoba; University of Granada;
   Universidad de Jaen; IMDEA Food Institute; Consejo Superior de
   Investigaciones Cientificas (CSIC); CIBER - Centro de Investigacion
   Biomedica en Red; CIBERDEM; Instituto de Salud Carlos III; University of
   Barcelona; Hospital Clinic de Barcelona; IDIBAPS; University of
   Barcelona; Hospital Clinic de Barcelona; IDIBAPS; University of
   Barcelona; Servicio Navarro de Salud - Osasunbidea
RP Tur, JA (corresponding author), Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr CIBEROBN, Madrid 28029, Spain.; Tur, JA (corresponding author), Univ Balearic Isl, Res Grp Community Nutr & Oxidat Stress, Palma de Mallorca 07122, Spain.; Tur, JA (corresponding author), Hlth Res Inst Balear Isl IdISBa, Palma de Mallorca 07120, Spain.
EM lauragala3@gmail.com; mar.bibiloni@uib.es; catalinamaria95@hormail.es;
   sofiamf16@gmail.com; mcanela@unav.es; jordi.salas@urv.cat;
   dolores.corella@uv.es; mfito@imim.es; mariaadoracion.romaguera@ssib.es;
   vioque@umh.es; angelmago13@gmail.com; jwarnberg@uma.es;
   jalfredo.martinez@imdea.org; lluis.serra@ulpgc.es; restruch@clinic.cat;
   fjtinahones@hotmail.com; joselapetra543@gmail.com;
   xpinto@bellvitgehospital.cat; angarios2004@yahoo.es; abueno@ugr.es;
   mdelgado@ujaen.es; pilar.matia@gmail.com; lidia.daimiel@imdea.org;
   socochato68@gmail.com; jovidal@clinic.cat; cvazquez@fjd.es;
   EROS@clinic.cat; cflazaro@unav.es; nerea.becerra@urv.cat;
   i.gimenez.alba@valencia.edu; mzomeno@imim.es; jadzia.koieczna@gmail.com;
   lcompan@umh.es; lutojal@hotmail.com; jessicaperezlopez@uma.es;
   mazulet@unav.es; tamara.nutricion@gmail.com; scastro@clinic.cat;
   anamgp86@gmail.com; josemanuel.santos.lozano@gmail.com;
   agalera@idibell.cat; javierbasterra@hotmail.com;
   jbasora.tgn.ics@gencat.cat; carmen.saiz@uv.es; kperez@imim.es;
   aina.galmes.panades@gmail.com; daisysorto2@yahoo.com; msayon@unav.es;
   jesusfrancisco.garcia@urv.cat; juliamm02@gmail.com; pep.tur@uib.es
RI Lapetra, Jose/F-2552-2015; Pintó, Xavier/AGI-4297-2022; Vidal,
   Josep/MIK-6936-2025; Tur, Josep/AAE-5748-2020; Gallardo-Alfaro,
   Laura/AAB-3363-2021; Martinez, Juan/GXM-4393-2022; Alba,
   Ignacio/ABI-4663-2020; Ruiz-Canela, Miguel/JYP-1794-2024;
   García-Gavilán, Jesús/ABG-9982-2020; Fernandez-Lazaro,
   Cesar/V-6390-2019; Tejada, Silvia/L-7297-2014; Konieczna,
   Jadwiga/AAB-2817-2020; López, Jessica/AAH-2712-2020; Romaguera,
   Dora/ABE-7004-2020; Galmes-Panades, Aina/AAB-8361-2021; Estruch,
   Ramon/AAZ-3723-2020; PerezVega, KarlaAlejandra/LZG-9715-2025;
   Muñoz-Martínez, Júlia/ABD-0340-2022; Santos, João/HHZ-5595-2022; Vioque,
   Jesus/A-1066-2008; ALONSO GOMEZ, ANGEL/HLG-2476-2023; Gabucio,
   Laura/AAN-6068-2020; Fito Colomer, Montse/C-1822-2012; Ruiz-Canela,
   Miguel/I-7738-2016; Sayon-Orea, Carmen/A-9828-2017; Fernandez Garcia,
   Jose Carlos/B-3723-2013; Zulet, M. Angeles/H-1317-2017; Bueno
   Cavanillas, Aurora/O-1513-2015; Santos Lozano, Jose Manuel/J-9312-2018;
   Becerra-Tomas, Nerea/H-3937-2018; Tur, Josep/F-5576-2014; Daimiel-Ruiz,
   Lidia Angeles/M-7779-2014; Warnberg, Julia/G-1390-2011; Salas-Salvado,
   Jordi/C-7229-2017; Perez Lopez, Jessica/H-3985-2018; Corella,
   Dolores/L-9888-2014
OI Perez-Vega, Karla Alejandra/0000-0002-7524-2034; MATIA MARTIN, MARIA DEL
   PILAR/0000-0001-9844-3755; Pinto Sala, Xavier/0000-0002-2216-2444; Fito
   Colomer, Montse/0000-0002-1817-483X; Ruiz-Canela,
   Miguel/0000-0002-7684-2787; Sayon-Orea, Carmen/0000-0002-4137-3263; Ros,
   Emilio/0000-0002-2573-1294; Mascaro Bestard, Catalina
   Maria/0000-0002-8235-2768; Fernandez Garcia, Jose
   Carlos/0000-0003-2308-2865; Vioque, Jesus/0000-0002-2284-148X; Zulet, M.
   Angeles/0000-0002-3926-0892; Basora, Josep/0000-0003-0278-1149; Bueno
   Cavanillas, Aurora/0000-0002-0649-3016; Santos Lozano, Jose
   Manuel/0000-0001-7097-5653; Munoz-Martinez, Julia/0000-0002-1817-8937;
   Garcia-Gavilan, Jesus Francisco/0000-0002-3707-5255; Romaguera,
   Dora/0000-0002-5762-8558; Zomeno, M. Dolores/0000-0003-1280-7680;
   Gimenez Alba, Ignacio Manuel/0000-0002-6380-8467; Becerra-Tomas,
   Nerea/0000-0002-4429-6507; Tur, Josep/0000-0002-6940-0761; Daimiel-Ruiz,
   Lidia Angeles/0000-0001-9898-6629; Vazquez,
   Clotilde/0000-0003-1629-2143; Estruch, Ramon/0000-0003-1260-4445;
   Serra-Majem, Lluis/0000-0002-9658-9061; Warnberg,
   Julia/0000-0002-8408-316X; Gallardo Alfaro, Laura/0000-0002-5769-706X;
   Salas-Salvado, Jordi/0000-0003-2700-7459; Perez Lopez,
   Jessica/0000-0003-2579-716X; Fernandez-Lazaro, Cesar
   I./0000-0003-2366-2528; Tercero Macia, Cristina/0009-0000-6092-9231;
   galmes, aina/0000-0001-6977-9874; Tojal Sierra,
   Lucas/0000-0001-5338-9601; Compan Gabucio, Laura M/0000-0001-5324-1535;
   Alonso Gomez, Angel Maria/0000-0003-2945-7509; Corella,
   Dolores/0000-0002-2366-4104; Gomez Perez, Ana Maria/0000-0002-2874-5894;
   Vidal Cortada, Josep/0000-0002-4564-4518
FU official funding agency for biomedical research of the Spanish
   government, ISCIII, through the Fondo de Investigacion para la Salud
   (FIS); European Regional Development Fund [PI13/00673, PI13/00492,
   PI13/00272, PI13/01123, PI13/00462, PI13/00233, PI13/02184, PI13/00728,
   PI13/01090, PI13/01056, PI14/01722, PI14/00636]; Especial Action
   Project; European Research Council [340918]; Recercaixa Grant
   [2013ACUP00194]; Consejeria de Salud de la Junta de Andalucia
   [PI0458/2013, PS0358/2016, PI0137/2018]; Generalitat Valenciana
   [PROMETEO/2017/017]; SEMERGEN Grant; EU-COST Action [CA16112]; Balearic
   Islands Government [35/2011]; Balearic Islands Health Research Institute
   IDISBA; European Commission [EAT2BENICE_H2020_SFS2016]; Fundacio La
   Marato TV3 [PI044003, 201630.10]; Spanish Ministry of Education; 
   [PI14/00618];  [PI14/00696];  [PI14/01206];  [PI14/01919]; 
   [PI14/00853];  [PI14/01374];  [PI14/00972];  [PI14/00728]; 
   [PI14/01471];  [PI16/00473];  [PI16/00662];  [PI16/01873]; 
   [PI16/01094];  [PI16/00501];  [PI16/00533];  [PI16/00381]; 
   [PI16/00366];  [PI16/01522];  [PI16/01120];  [PI17/00764]; 
   [PI17/01183];  [PI17/00855];  [PI17/01347];  [PI17/00525]; 
   [PI17/01827];  [PI17/00532];  [PI17/00215];  [PI17/01441]; 
   [PI17/00508];  [PI17/01732];  [PI17/00926];  [PI19/00957]; 
   [PI19/00386];  [PI19/00309];  [PI19/01032];  [PI19/00576]; 
   [PI19/00017];  [PI19/01226];  [PI19/00781];  [PI19/01560]; 
   [PI19/01332];  [CIBEROBN CB06/03];  [CB12/03]
FX The PREDIMED-Plus trial was supported by the official funding agency for
   biomedical research of the Spanish government, ISCIII, through the Fondo
   de Investigacion para la Salud (FIS), which is co-funded by the European
   Regional Development Fund [five coordinated FIS projects led by Jordi
   Salas-Salvado and Josep Vidal, including the following projects:
   PI13/00673, PI13/00492, PI13/00272, PI13/01123, PI13/00462, PI13/00233,
   PI13/02184, PI13/00728, PI13/01090, PI13/01056, PI14/01722, PI14/00636,
   PI14/00618, PI14/00696, PI14/01206, PI14/01919, PI14/00853, PI14/01374,
   PI14/00972, PI14/00728, PI14/01471, PI16/00473, PI16/00662, PI16/01873,
   PI16/01094, PI16/00501, PI16/00533, PI16/00381, PI16/00366, PI16/01522,
   PI16/01120, PI17/00764, PI17/01183, PI17/00855, PI17/01347, PI17/00525,
   PI17/01827, PI17/00532, PI17/00215, PI17/01441, PI17/00508, PI17/01732,
   PI17/00926, PI19/00957, PI19/00386, PI19/00309, PI19/01032, PI19/00576,
   PI19/00017, PI19/01226, PI19/00781, PI19/01560, and PI19/01332], the
   Especial Action Project entitled: Implementacion y evaluacion de una
   intervencion intensiva sobre la actividad fisica Cohorte PREDIMED-Plus
   grant to Jordi Salas-Salvado, the European Research Council (Advanced
   Research Grant 2014-2019, 340918) to Dr. Miguel A. Martinez-Gonzalez,
   the Recercaixa Grant to Jordi Salas-Salvado (2013ACUP00194), Grants from
   the Consejeria de Salud de la Junta de Andalucia (PI0458/2013,
   PS0358/2016, and PI0137/2018), a Grant from the Generalitat Valenciana
   (PROMETEO/2017/017), a SEMERGEN Grant, EU-COST Action CA16112, a Grant
   of support to research groups no. 35/2011 from the Balearic Islands
   Government, Grants from Balearic Islands Health Research Institute
   IDISBA [FOLIUM, PRIMUS, SYNERGIA, and LIBERI], funds from the European
   Regional Development Fund (CIBEROBN CB06/03 and CB12/03) and from the
   European Commission (EAT2BENICE_H2020_SFS2016). Fundacio La Marato TV3
   (projects no. PI044003 and 201630.10). Laura Gallardo-Alfaro and
   Catalina M. Mascaro received FPU PhD Grants from the Spanish Ministry of
   Education. The funding sponsors had no role in the design of the study,
   in the collection, analyses, or interpretation of the data; in the
   writing of the manuscript, and in the decision to publish the results.
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NR 57
TC 76
Z9 81
U1 6
U2 41
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD APR
PY 2020
VL 12
IS 4
AR 1013
DI 10.3390/nu12041013
PG 20
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA LL8VE
UT WOS:000531831300133
PM 32272653
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Beydoun, MA
   Beydoun, HA
   Boueiz, A
   Shroff, MR
   Zonderman, AB
AF Beydoun, May A.
   Beydoun, Hind A.
   Boueiz, Adel
   Shroff, Monal R.
   Zonderman, Alan B.
TI Antioxidant status and its association with elevated depressive symptoms
   among US adults: National Health and Nutrition Examination Surveys
   2005-6
SO BRITISH JOURNAL OF NUTRITION
LA English
DT Article
DE Depressive symptoms; Antioxidants; Carotenoids; Adults
ID OXIDATIVE STRESS; LIPID-PEROXIDATION; METABOLIC SYNDROME; VITAMIN-E;
   PSYCHOLOGICAL STRESS; ALCOHOL DEPENDENCE; MAJOR DEPRESSION; SAMPLE
   SELECTION; FREE-RADICALS; SERUM FOLATE
AB We examined the relationship of elevated depressive symptoms with antioxidant status. Cross-sectional data from the National Health and Nutrition Examination Surveys 2005-6 on US adults aged 20-85 years were analysed. Depressive symptoms were measured using the Patient Health Questionnaire with a score cut-off point of 10 to define 'elevated depressive symptoms'. Serum antioxidant status was measured by serum levels of carotenoids, retinol (free and retinyl esters), vitamin C and vitamin E. The main analyses consisted of multiple logistic and zero-inflated Poisson regression models, taking into account sampling design complexity. The final sample consisted of 1798 US adults with complete data. A higher total serum carotenoid level was associated with a lower likelihood of elevated depressive symptoms with a reduction in the odds by 37% overall with each SD increase in exposure, and by 34% among women (P<0.05). A dose-response relationship was observed when total serum carotenoids were expressed as quartiles (Q(4 (1.62-10.1 mu mol/l)) v. Q(1 (0.06-0.86 mu mol/l)): OR 0.41; 95% CI 0.23, 0.76, P<0.001; P for trend=0.035), though no significant associations were found with the other antioxidant levels. Among carotenoids, beta-carotene (men and women combined) and lutein + zeaxanthins (women only, after control for dietary lutein + zeaxanthin intake and supplement use) had an independent inverse association with elevated depressive symptoms among US adults. None of the other serum antioxidants had a significant association with depressive symptoms, independently of total carotenoids and other covariates. In conclusion, total carotenoids (mainly beta-carotene and lutein + zeaxanthins) in serum were associated with reduced levels of depressive symptoms among community-dwelling US adults.
C1 [Beydoun, May A.; Zonderman, Alan B.] NIA, NIH, Biomed Res Ctr, IRP, Baltimore, MD 21224 USA.
   [Beydoun, Hind A.] Eastern Virginia Med Sch, Grad Program Publ Hlth, Norfolk, VA 23501 USA.
   [Boueiz, Adel] Johns Hopkins Univ, Dept Internal Med, Baltimore, MD USA.
   [Shroff, Monal R.] Univ Michigan, Dept Epidemiol, Ann Arbor, MI 48109 USA.
C3 National Institutes of Health (NIH) - USA; NIH National Institute on
   Aging (NIA); Eastern Virginia Medical School; Johns Hopkins University;
   University of Michigan System; University of Michigan
RP Beydoun, MA (corresponding author), NIA, NIH, Biomed Res Ctr, IRP, 251 Bayview Blvd,Suite 100,Room 04B118, Baltimore, MD 21224 USA.
EM baydounm@mail.nih.gov
RI Zonderman, Alan/A-5807-2013; Boueiz, Adel/AAV-5966-2021
OI El Boueiz, Adel`/0000-0003-1638-8575; Zonderman, Alan
   B/0000-0002-6523-4778
FU Intramural Research Program of the National Institute on Aging,
   NIA/NIH/IRP
FX This study was fully supported by the Intramural Research Program of the
   National Institute on Aging, NIA/NIH/IRP. The contributions of each
   author are as follows: M. A. B. contributed to the conceptualisation of
   the study, the literature review, the plan of the analysis, the data
   management and statistical analysis, and the writing and revision of the
   manuscript; H. A. B. contributed to the literature search and review,
   the plan of the analysis, the writing of part of the paper and the
   revision of the manuscript; A. B. carried out the literature search and
   review, wrote part of the paper and revised the manuscript; M. R. S.
   carried out the literature search, drafted the plan of the analysis,
   wrote part of the paper and revised the manuscript; A. B. Z. drafted the
   plan of the analysis, wrote part of the paper and revised the
   manuscript. The authors declare that there is no conflict of interest.
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NR 80
TC 39
Z9 44
U1 0
U2 16
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1145
EI 1475-2662
J9 BRIT J NUTR
JI Br. J. Nutr.
PD MAY 14
PY 2013
VL 109
IS 9
BP 1714
EP 1729
DI 10.1017/S0007114512003467
PG 16
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 136LT
UT WOS:000318364100020
PM 22935166
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Prabhakar, P
   Reeta, KH
   Maulik, SK
   Dinda, AK
   Gupta, YK
AF Prabhakar, Pankaj
   Reeta, K. H.
   Maulik, Subir Kumar
   Dinda, Amit Kumar
   Gupta, Yogendra Kumar
TI α-Amyrin attenuates high fructose diet-induced metabolic syndrome in
   rats
SO APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
LA English
DT Article
DE alpha-amyrin; metabolic syndrome; high-fructose diet; oxidative stress;
   PPAR-alpha
ID PROLIFERATOR-ACTIVATED RECEPTORS; HEPATIC OXIDATIVE STRESS; FATTY LIVER;
   BETA-AMYRIN; PROTIUM-HEPTAPHYLLUM; INSULIN-RESISTANCE; PENTACYCLIC
   TRITERPENE; WISTAR RATS; HYPERTENSION; PREVENTS
AB This study investigated the effect of alpha-amyrin (a pentacyclic triterpene) on high-fructose diet (HFD)-induced metabolic syndrome in rats. Male Wistar rats were randomly distributed into different groups. The control group was fed normal rat chow diet. The HFD group was fed HFD (60%; w/w) for 42 days. Pioglitazone (10 mg/kg, orally, once daily) was used as a standard drug. alpha-Amyrin was administered in 3 doses (50, 100, and 200 mg/kg, orally, once daily along with HFD). Plasma glucose, total cholesterol, triglycerides, and high-density lipoprotein cholesterol (HDL-C) were estimated. Changes in blood pressure, oral glucose tolerance, and insulin tolerance were measured. Hepatic oxidative stress as well as messenger RNA (mRNA) and protein levels of peroxisome proliferator-activated receptor alpha (PPAR-alpha) were analyzed. A significant increase in systolic blood pressure, plasma glucose, total cholesterol, and plasma triglycerides and a significant decrease in HDL-C were observed in HFD rats as compared with control rats. Glucose tolerance and insulin tolerance were also significantly impaired with HFD. alpha-Amyrin prevented these changes in a dose-dependent manner. Hepatic oxidative stress as well as micro-and macrovesicular fatty changes in hepatocytes caused by HFD were also attenuated by alpha-amyrin. alpha-Amyrin preserved the hepatic mRNA and protein levels of PPAR-alpha, which was reduced in HFD group. This study thus demonstrates that alpha-amyrin attenuates HFD-induced metabolic syndrome in rats.
C1 [Prabhakar, Pankaj; Reeta, K. H.; Maulik, Subir Kumar; Gupta, Yogendra Kumar] All India Inst Med Sci, Dept Pharmacol, New Delhi 110029, India.
   [Dinda, Amit Kumar] All India Inst Med Sci, Dept Pathol, New Delhi 110029, India.
C3 All India Institute of Medical Sciences (AIIMS) New Delhi; All India
   Institute of Medical Sciences (AIIMS) New Delhi
RP Reeta, KH (corresponding author), All India Inst Med Sci, Dept Pharmacol, New Delhi 110029, India.
EM reetakh@gmail.com
RI Reeta, Kh/AAU-2462-2021; Prabhakar, Dr. Pankaj/GOH-1003-2022
OI Prabhakar, Dr. Pankaj/0000-0002-1630-4258
FU Indian Council of Medical Research (ICMR), New Delhi, India
FX Authors gratefully acknowledge the Indian Council of Medical Research
   (ICMR), New Delhi, India, for financial support.
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NR 63
TC 20
Z9 22
U1 0
U2 13
PU CANADIAN SCIENCE PUBLISHING
PI OTTAWA
PA 65 AURIGA DR, SUITE 203, OTTAWA, ON K2E 7W6, CANADA
SN 1715-5312
EI 1715-5320
J9 APPL PHYSIOL NUTR ME
JI Appl. Physiol. Nutr. Metab.
PD JAN
PY 2017
VL 42
IS 1
BP 23
EP 32
DI 10.1139/apnm-2016-0088
PG 10
WC Nutrition & Dietetics; Physiology; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics; Physiology; Sport Sciences
GA EI1OC
UT WOS:000392245900004
PM 27911087
DA 2025-06-11
ER

PT J
AU Gaggini, M
   Michelucci, E
   Ndreu, R
   Rocchiccioli, S
   Chatzianagnostou, K
   Berti, S
   Vassalle, C
AF Gaggini, Melania
   Michelucci, Elena
   Ndreu, Rudina
   Rocchiccioli, Silvia
   Chatzianagnostou, Kyriazoula
   Berti, Sergio
   Vassalle, Cristina
TI Lipidomic Analysis to Assess the Correlation between Ceramides, Stress
   Hyperglycemia, and HbA1c in Acute Myocardial Infarction
SO MOLECULES
LA English
DT Article
DE ceramides; acute myocardial infarction; acute hyperglycemia; type 2
   diabetes; glycated hemoglobin
ID INFLAMMATION; HEMOGLOBIN; DEATH; RISK; LDL
AB Ceramides have been associated with cardiometabolic disease (e.g., acute myocardial infarction (AMI) and type 2 diabetes (T2D)) and adverse outcomes. Acute admission hyperglycemia (AH) is a transient glucose alteration in response to stress. As glycated hemoglobin (HbA1c) reflects the glycemia over a longer period of time, its use may be helpful in distinguishing between the AH and hyperglycemia associated with T2D in the AMI setting. The aim was to assess the correlation of ceramides with both AH (defined as an admission glucose level >= 140 mg/dL in the absence of T2D) and HbA1c-T2D and other demographic, clinical, and inflammatory-related biomarkers in AMI. High-performance liquid chromatography-tandem mass spectrometry was used to identify nine ceramide species, and their three ratios, in 140 AMI patients (FTGM coronary unit, Massa, Italy). The ceramides did not correlate with stress hyperglycemia, but specific species were elevated in T2D-AMI. Moreover, some ceramides were associated with other cardiometabolic risk factors. Ceramides assessment may be helpful in better understanding the pathogenic molecular mechanisms underlying myocardial acute events and cardiometabolic risk, as a basis for the future evaluation of their role as prognostic predictors and therapeutic targets in T2D-AMI patients.
C1 [Gaggini, Melania; Michelucci, Elena; Ndreu, Rudina; Rocchiccioli, Silvia] CNR, Inst Clin Physiol, Via G Moruzzi 1, I-56124 Pisa, Italy.
   [Michelucci, Elena] CNR, Inst Chem Organometall Cpds, Via G Moruzzi 1, I-56124 Pisa, Italy.
   [Chatzianagnostou, Kyriazoula; Vassalle, Cristina] Fdn CNR Reg Toscana G Monasterio, I-56124 Pisa, Italy.
   [Berti, Sergio] Fdn CNR Reg Toscana G Monasterio, I-54100 Massa, Italy.
C3 Consiglio Nazionale delle Ricerche (CNR); Istituto di Fisiologia Clinica
   (IFC-CNR); Consiglio Nazionale delle Ricerche (CNR); Isituto di Chimica
   dei Composti Organometallici (ICCOM-CNR)
RP Vassalle, C (corresponding author), Fdn CNR Reg Toscana G Monasterio, I-56124 Pisa, Italy.
EM cristina.vassalle@ftgm.it
RI Michelucci, Elena/ABA-2143-2022; Rocchiccioli, Silvia/K-6833-2016;
   Gaggini, Melania/C-9379-2017
OI Gaggini, Melania/0000-0002-6311-502X; Ndreu, Rudina/0000-0003-1198-9822;
   MICHELUCCI, ELENA/0000-0002-1619-401X; VASSALLE,
   CRISTINA/0000-0003-3438-6450; Berti, Sergio/0000-0002-5244-0556;
   Rocchiccioli, Silvia/0000-0003-3831-4200
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NR 36
TC 8
Z9 9
U1 1
U2 4
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1420-3049
J9 MOLECULES
JI Molecules
PD JAN
PY 2023
VL 28
IS 2
AR 716
DI 10.3390/molecules28020716
PG 10
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 8A6PI
UT WOS:000916358800001
PM 36677773
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Slyepchenko, A
   Maes, M
   Machado-Vieira, R
   Anderson, G
   Solmi, M
   Sanz, Y
   Berk, M
   Köhler, CA
   Carvalho, AF
AF Slyepchenko, Anastasiya
   Maes, Michael
   Machado-Vieira, Rodrigo
   Anderson, George
   Solmi, Marco
   Sanz, Yolanda
   Berk, Michael
   Kohler, Cristiano A.
   Carvalho, Andre F.
TI Intestinal Dysbiosis, Gut Hyperpermeability and Bacterial Translocation:
   Missing Links Between Depression, Obesity and Type 2 Diabetes?
SO CURRENT PHARMACEUTICAL DESIGN
LA English
DT Review
DE Microbiome; gut; probiotics; type 2 diabetes mellitus; obesity;
   metabolic syndrome; major depressive disorder; psychiatry
ID NECROSIS-FACTOR-ALPHA; INCREASED OXIDATIVE STRESS; ANXIETY-LIKE
   BEHAVIOR; C-REACTIVE PROTEIN; CHAIN FATTY-ACIDS;
   LACTOBACILLUS-HELVETICUS R0052; BIFIDOBACTERIUM-LONGUM R0175;
   IMMUNO-INFLAMMATORY PATHWAYS; COMMON MENTAL-DISORDERS; PLASMA GHRELIN
   LEVELS
AB The comorbid prevalence of major depressive disorder (MDD) with obesity and type II diabetes mellitus reflects the existence of a subset of individuals with a complex common pathophysiology and overlapping risk factors. Such comorbid disease presentations imply a number of difficulties, including: decreased treatment responsivity and adherence; altered glycemic control and increased risk of wider medical complications. A number of factors link MDD to metabolic-associated disorders, including: higher rates of shared risk factors such as poor diet and physical inactivity and biological elements including increased inflammation; insulin resistance; oxidative and nitrosative stress; and mitochondrial dysfunction. All of these biological factors have been extensively investigated in the pathophysiology of obesity and type 2 diabetes mellitus as well as MDD. In this review, we aim to: (1) overview the epidemiological links between MDD, obesity and type 2 diabetes mellitus; (2) discuss the role of synergistic neurotoxic effects in MDD comorbid with obesity, and type 2 diabetes mellitus; (3) review evidence of intestinal dysbiosis, leaky gut and increased bacterial translocation, in the pathophysiology of MDD, obesity and type 2 diabetes mellitus; and (4) propose a model in which the gut-brain axis could play a pivotal role in the comorbidity of these disorders.
C1 [Slyepchenko, Anastasiya] McMaster Univ, MiNDS, McMaster Integrat Neurosci Discovery & Study, Hamilton, ON, Canada.
   [Slyepchenko, Anastasiya] St Josephs Healthcare Hamilton, Womens Hlth Concerns Clin, Hamilton, ON, Canada.
   [Maes, Michael] Chulalongkorn Univ, Dept Psychiat, Fac Med, Bangkok, Thailand.
   [Maes, Michael; Berk, Michael] Deakin Univ, IMPACT Res Ctr, Geelong, Vic, Australia.
   [Maes, Michael] Univ Estadual Londrina, Fac Med, Dept Psychiat, Londrina, Brazil.
   [Maes, Michael] Med Univ Plovdiv, Dept Psychiat, Plovdiv, Bulgaria.
   [Maes, Michael] Revitalis, Waalre, Netherlands.
   [Machado-Vieira, Rodrigo] Univ Sao Paulo, Lab Neurosci LIM 27, Dept & Inst Psychiat, Fac Med, BR-05508 Sao Paulo, Brazil.
   [Machado-Vieira, Rodrigo] NIMH, Expt Therapeut & Pathophysiol Branch, NIH, Bethesda, MD 20892 USA.
   [Anderson, George] CRC Scotland & London, Eccleston Sq, London, England.
   [Solmi, Marco] Univ Padua, Dept Neurosci, Padua, Italy.
   [Solmi, Marco] Mental Hlth Dept, Local Hlth Unit 17, Padua, Italy.
   [Solmi, Marco] IREM, Inst Clin Res & Educ Med, Padua, Italy.
   [Sanz, Yolanda] Natl Res Council IATA CSIC, Microbial Ecol Nutr & Hlth Res Unit, Inst Agrochem & Food Technol, Av Agustin Escardino 7, Paterna Valencia 46980, Spain.
   [Berk, Michael] Univ Melbourne, Dept Psychiat, Florey Inst Neurosci & Mental Hlth, Ctr Youth Mental Hlth, Parkville, Vic, Australia.
   [Berk, Michael] Univ Melbourne, Orygen Natl Ctr Excellence Youth Mental Hlth, Ctr Youth Mental Hlth, Parkville, Vic, Australia.
   [Kohler, Cristiano A.; Carvalho, Andre F.] Univ Fed Ceara, Dept Clin Med, Fac Med, Rua Prof Costa Mendes 1608,4 Andar, BR-60430040 Fortaleza, Ceara, Brazil.
   [Kohler, Cristiano A.; Carvalho, Andre F.] Univ Fed Ceara, Translat Psychiat Res Grp, Fac Med, Fortaleza, Ceara, Brazil.
C3 McMaster University; McMaster University; Chulalongkorn University;
   Deakin University; Universidade Estadual de Londrina; Medical University
   Plovdiv; Universidade de Sao Paulo; National Institutes of Health (NIH)
   - USA; NIH National Institute of Mental Health (NIMH); University of
   Padua; Consejo Superior de Investigaciones Cientificas (CSIC); Instituto
   de Agroquimica y Tecnologia de los Alimentos (IATA); Florey Institute of
   Neuroscience & Mental Health; University of Melbourne; Orygen, The
   National Centre of Excellence in Youth Mental Health; University of
   Melbourne; Orygen, The National Centre of Excellence in Youth Mental
   Health; Universidade Federal do Ceara; Universidade Federal do Ceara
RP Carvalho, AF (corresponding author), Univ Fed Ceara, Dept Clin Med, Fac Med, Rua Prof Costa Mendes 1608,4 Andar, BR-60430040 Fortaleza, Ceara, Brazil.
EM andrefc7@terra.com.br
RI solmi, marco/K-3906-2018; Slyepchenko, Anastasiya/AAK-6000-2021;
   Carvalho, Andre/AEZ-4001-2022; Berk, Michael/AGH-9427-2022; Maes,
   Michael/B-8546-2011; Anderson, George/AEO-3626-2022; MACHADO-VIEIRA,
   RODRIGO/D-8293-2012; Berk, Michael/M-7891-2013; Sanz,
   Yolanda/H-5498-2012
OI Anderson, George/0000-0001-7243-0817; Maes, Michael/0000-0002-2012-871X;
   solmi, marco/0000-0003-4877-7233; MACHADO-VIEIRA,
   RODRIGO/0000-0002-4830-1190; Berk, Michael/0000-0002-5554-6946; Sanz,
   Yolanda/0000-0002-1615-1976; Slyepchenko, Anastasiya/0000-0003-0179-2129
FU European Union [613979]; Spanish Ministry of Economy and Competitiveness
   (MINECO, Spain) [AGL2014-52101-P]; NHMRC [1059660]; Conselho Nacional de
   Desenvolvimento Cientifico e Tecnologico (CNPq; Brazil)
FX YS contribution is supported by the European Union's Seventh Framework
   Program under the grant agreement no 613979 (MyNewGut) and the Spanish
   Ministry of Economy and Competitiveness (MINECO, Spain) grant
   AGL2014-52101-P. MB is supported by a NHMRC Senior Principal Research
   Fellowship 1059660. AFC is supported by a research fellowship award from
   Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq;
   Brazil).
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NR 329
TC 84
Z9 92
U1 1
U2 56
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1381-6128
EI 1873-4286
J9 CURR PHARM DESIGN
JI Curr. Pharm. Design
PY 2016
VL 22
IS 40
BP 6087
EP 6106
DI 10.2174/1381612822666160922165706
PG 20
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Pharmacology & Pharmacy
GA EF9LE
UT WOS:000390650900004
PM 27669970
DA 2025-06-11
ER

PT J
AU Wu, SS
   Kor, CT
   Chen, TY
   Liu, KH
   Shih, KL
   Su, WW
   Wu, HM
AF Wu, Shun-Sheng
   Kor, Chew-Teng
   Chen, Ting-Yu
   Liu, Ko-Hung
   Shih, Kai-Lun
   Su, Wei-Wen
   Wu, Hung-Ming
TI Relationships between Serum Uric Acid, Malondialdehyde Levels, and
   Carotid Intima-Media Thickness in the Patients with Metabolic Syndrome
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Article
ID OXIDATIVE STRESS; CARDIOVASCULAR RISK; ATHEROSCLEROSIS; HYPERGLYCEMIA;
   INFLAMMATION; HYPERTENSION; ASSOCIATION; BIOMARKERS; STIFFNESS; BEHAVIOR
AB Oxidative stress is the major cause of atherosclerosis and cardiovascular diseases. This cross-sectional study is aimed at determining if parallel serum markers of oxidative stress are related to carotid intima-media thickness (IMT). We enrolled 134 participants with varied metabolic syndrome (Met-S) scores (zero, n = 21; one, n = 19; two, n = 27; three, n = 26; four, n = 25; five, n = 16). Biochemical profiles and potential oxidative stress biomarkers malondialdehyde (MDA) and uric acid were measured in fasting plasma. We found that carotid IMT positively correlated with both MDA and uric acid levels. Multivariate analysis revealed that both MDA (p < 0.05) and uric acid (p < 0.01) levels were significantly associated with carotid IMT in participants whose Met-S scores were >= 1 or >= 2. However, only uric acid (p < 0.01) levels were positively associated with carotid IMT in patients with metabolic syndrome. Linear regression model analysis revealed that the prediction accuracies for carotid IMT from MDA combined with uric acid and from a combination of MDA, uric acid, and Met-S score were 0.176 and 0.237, respectively. These were better than the predication accuracies from MDA (r(2) = 0.075) and uric acid (r(2) = 0.148) individually. These results suggest that measuring uric acid levels along with MDA biomarkers and Met-S scores may be a promising step in the development of an effective model for monitoring the severity of carotid IMT and atherosclerosis in the patients with metabolic syndrome.
C1 [Wu, Shun-Sheng; Shih, Kai-Lun; Su, Wei-Wen] Changhua Christian Hosp, Dept Gastroenterol, Changhua, Taiwan.
   [Kor, Chew-Teng] Changhua Christian Hosp, Internal Med Res Ctr, Changhua, Taiwan.
   [Chen, Ting-Yu; Liu, Ko-Hung; Wu, Hung-Ming] Changhua Christian Hosp, Inflammat Res & Drug Dev Ctr, Changhua, Taiwan.
   [Wu, Hung-Ming] Changhua Christian Hosp, Dept Neurol, Changhua, Taiwan.
   [Wu, Hung-Ming] China Med Univ, Grad Inst Acupuncture Sci, Taichung, Taiwan.
C3 Changhua Christian Hospital; Changhua Christian Hospital; Changhua
   Christian Hospital; Changhua Christian Hospital; China Medical
   University Taiwan
RP Wu, HM (corresponding author), Changhua Christian Hosp, Inflammat Res & Drug Dev Ctr, Changhua, Taiwan.; Wu, HM (corresponding author), Changhua Christian Hosp, Dept Neurol, Changhua, Taiwan.; Wu, HM (corresponding author), China Med Univ, Grad Inst Acupuncture Sci, Taichung, Taiwan.
EM 18288@cch.org.tw
OI SHIH, KAI-LUN/0000-0003-4405-6033
FU Changhua Christian Hospital Research Foundation [100-CCH-IRP-15,
   107CCH-HCR-044, 107-CCH-NPI-052]
FX This study was funded by grants 100-CCH-IRP-15, 107CCH-HCR-044, and
   107-CCH-NPI-052 from the Changhua Christian Hospital Research
   Foundation.
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NR 42
TC 18
Z9 19
U1 0
U2 9
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PD OCT 9
PY 2019
VL 2019
AR 6859757
DI 10.1155/2019/6859757
PG 9
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA JH8EJ
UT WOS:000493001200002
PM 31687084
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Russo, E
   Leoncini, G
   Esposito, P
   Garibotto, G
   Pontremoli, R
   Viazzi, F
AF Russo, Elisa
   Leoncini, Giovanna
   Esposito, Pasquale
   Garibotto, Giacomo
   Pontremoli, Roberto
   Viazzi, Francesca
TI Fructose and Uric Acid: Major Mediators of Cardiovascular Disease Risk
   Starting at Pediatric Age
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE fructose; uric acid; URAT-1; cardiovascular risk; children; metabolic
   syndrome; hypertension; NAFLD
ID SUGAR-SWEETENED BEVERAGES; FATTY LIVER-DISEASE; CHRONIC KIDNEY-DISEASE;
   METABOLIC SYNDROME; INSULIN-RESISTANCE; BLOOD-PRESSURE;
   ESSENTIAL-HYPERTENSION; HEPATIC STEATOSIS; OXIDATIVE STRESS; PROXIMAL
   TUBULE
AB Recently, there has been a growing interest in epidemiological and clinical studies supporting a pathogenetic role of fructose in cardio-metabolic diseases, especially in children and adolescents. In the present review, we summarize experimental data on the potential biological mechanisms linking fructose and uric acid in the development of insulin resistance, metabolic syndrome, obesity, diabetes, hypertension, non-alcoholic fatty liver disease and chronic renal disease, thereby contributing to an increase in cardiovascular risk at pediatric age.
C1 [Russo, Elisa; Esposito, Pasquale; Garibotto, Giacomo; Viazzi, Francesca] Univ Genoa, Dipartimento Med Interna & Specialita Med, Osped Policlin San Martino, Clin Nefrol, I-16132 Genoa, Italy.
   [Leoncini, Giovanna; Pontremoli, Roberto] Univ Genoa, Dipartimento Med Interna & Specialita Med, Osped Policlin San Martino, Clin Med Inerna 2, I-16132 Genoa, Italy.
C3 University of Genoa; University of Genoa
RP Viazzi, F (corresponding author), Univ Genoa, Dipartimento Med Interna & Specialita Med, Osped Policlin San Martino, Clin Nefrol, I-16132 Genoa, Italy.
EM elisa24russo@gmail.com; giovanna.leoncini@unige.it;
   pasqualeesposito@hotmail.com; gari@unige.it;
   roberto.pontremoli@unige.it; francesca.viazzi@unige.it
RI Russo, Elisa/AAH-2246-2021; Esposito, Pasquale/NGR-5196-2025; Viazzi,
   Francesca/AAB-2479-2019; Garibotto, Giacomo/AAB-1190-2019
OI Esposito, Pasquale/0000-0002-0834-5586; Viazzi,
   Francesca/0000-0003-4219-7043; Russo, Elisa/0000-0003-1279-3178;
   GARIBOTTO, GIACOMO/0000-0001-6432-2429
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NR 101
TC 41
Z9 42
U1 2
U2 22
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD JUN
PY 2020
VL 21
IS 12
AR 4479
DI 10.3390/ijms21124479
PG 13
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA MR9TC
UT WOS:000553930700001
PM 32599713
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Rendina, D
   De Filippo, G
   D'Elia, L
   Strazzullo, P
AF Rendina, Domenico
   De Filippo, Gianpaolo
   D'Elia, Lanfranco
   Strazzullo, Pasquale
TI Metabolic syndrome and nephrolithiasis: a systematic review and
   meta-analysis of the scientific evidence
SO JOURNAL OF NEPHROLOGY
LA English
DT Review
DE Nephrolithiasis; Metabolic syndrome; Dietary habits; Adult age; Children
ID KIDNEY-STONES; URINE PH; PROVISIONAL REPORT; RISK; ASSOCIATION;
   PREVALENCE; GENDER; HYPERTENSION; POPULATION; MANAGEMENT
AB The metabolic syndrome is a cluster of cardiometabolic alterations at least partly dependent on reduced insulin sensitivity and hyperinsulinemia that can have several renal implications. A systematic review and meta-analysis of studies available in the international literature in English language demonstrates that the metabolic syndrome occurrence is associated with a significantly higher prevalence of nephrolithiasis (odds ratio 1.29, 95 % confidence intervals: 1.11-1.51). The pathophysiological bases of this association are currently not completely understood, however. Potential pathogenetic links between the two conditions include metabolic factors that promote insulin resistance as well as stone formation in urine, environmental factors such as diet, oxidative stress and inflammation, and molecular changes impacting the transport of some analytes in urine. Metabolic syndrome-related nephrolithiasis shows peculiar clinical and biochemical characteristics and should be considered a multifactorial systemic disorder needing a multidisciplinary approach for adequate prevention and management in pediatric and adult age.
C1 [Rendina, Domenico; De Filippo, Gianpaolo; D'Elia, Lanfranco; Strazzullo, Pasquale] Univ Naples Federico II, Dept Med & Surg, Naples, Italy.
   [Strazzullo, Pasquale] Univ Naples Federico II, Dept Med & Surg, Sch Med, Naples, Italy.
C3 University of Naples Federico II; University of Naples Federico II
RP Strazzullo, P (corresponding author), Univ Naples Federico II, Dept Med & Surg, Sch Med, Via S Pansini 5, Naples, Italy.
EM domenico.rendina@unina.it; strazzul@unina.it
RI De+Filippo, Gianpaolo/AAE-5584-2019; D'Elia, Lanfranco/U-6499-2017
OI D'Elia, Lanfranco/0000-0002-1782-0211; Rendina,
   Domenico/0000-0002-0331-0392
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NR 56
TC 41
Z9 52
U1 1
U2 17
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1121-8428
EI 1724-6059
J9 J NEPHROL
JI J. Nephrol.
PD AUG
PY 2014
VL 27
IS 4
BP 371
EP 376
DI 10.1007/s40620-014-0085-9
PG 6
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA AM3BK
UT WOS:000339726200003
PM 24696310
DA 2025-06-11
ER

PT J
AU Hughes, KA
   Webster, SP
   Walker, BR
AF Hughes, Katherine A.
   Webster, Scott P.
   Walker, Brian R.
TI 11-Beta-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors in
   Type 2 diabetes mellitus and obesity
SO EXPERT OPINION ON INVESTIGATIONAL DRUGS
LA English
DT Review
DE 11 beta-hydroxysteroid dehydrogenase type 1; glucocorticoids; metabolic
   syndrome; obesity; Type 2 diabetes
ID HEPATIC INSULIN SENSITIVITY; ADIPOSE-TISSUE DISTRIBUTION; ELEVATED
   PLASMA-CORTISOL; BODY-FAT DISTRIBUTION; BETA-KETO SULFONES;
   LOW-BIRTH-WEIGHT; SELECTIVE INHIBITORS; METABOLIC SYNDROME;
   GLUCOSE-TOLERANCE; HEXOSE-6-PHOSPHATE DEHYDROGENASE
AB Background: Glucocorticoids such as cortisol are important regulators of fuel metabolism during starvation and stress. Chronic glucocorticoid excess induces obesity with multiple features of the metabolic syndrome. Objective: In this article, we review the importance of glucocorticoids in metabolic syndrome and the approaches that have been explored to reduce glucocorticoid action as the basis for novel therapy of Type 2 diabetes and obesity. Method: We focus on the enzyme 11-beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1), which amplifies glucocorticoid concentrations in key metabolic tissues including liver and adipose tissue. Results/conclusion: Several 11 beta-HSD1 inhibitors are in late preclinical or early clinical development and we review here the properties of the class leaders and their potential as the next generation of drugs with multiple benefits in metabolic syndrome.
C1 [Hughes, Katherine A.; Webster, Scott P.; Walker, Brian R.] Univ Edinburgh, Queens Med Res Inst, Ctr Cardiovasc Sci, Endocrinol Unit, Edinburgh EH16 4TJ, Midlothian, Scotland.
C3 University of Edinburgh
RP Walker, BR (corresponding author), Univ Edinburgh, Queens Med Res Inst, Ctr Cardiovasc Sci, Endocrinol Unit, 47 Little France Crescent, Edinburgh EH16 4TJ, Midlothian, Scotland.
EM B.Walker@ed.ac.uk
OI Webster, Scott/0000-0003-4656-4744
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   PHARMAPROJECUS
   BIOVITRUM
NR 124
TC 84
Z9 114
U1 1
U2 6
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1354-3784
EI 1744-7658
J9 EXPERT OPIN INV DRUG
JI Expert Opin. Investig. Drugs
PD APR
PY 2008
VL 17
IS 4
BP 481
EP 496
DI 10.1517/13543784.17.4.481
PG 16
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 291VV
UT WOS:000255226100004
PM 18363514
DA 2025-06-11
ER

PT J
AU Malan-Müller, S
   Fairbairn, L
   Daniels, WMU
   Dashti, MJS
   Oakeley, EJ
   Altorfer, M
   Kidd, M
   Seedat, S
   Gamieldien, J
   Hemmings, SMJ
AF Malan-Mueller, Stefanie
   Fairbairn, Lorren
   Daniels, Willie M. U.
   Dashti, Mahjoubeh Jalali Sefid
   Oakeley, Edward J.
   Altorfer, Marc
   Kidd, Martin
   Seedat, Soraya
   Gamieldien, Junaid
   Hemmings, Sian Megan Joanna
TI Molecular mechanisms of D-cycloserine in facilitating fear extinction:
   insights from RNAseq
SO METABOLIC BRAIN DISEASE
LA English
DT Article
DE Anxiety disorders; D-cycloserine; RNA sequencing; transcriptomics; fear
   extinction
ID POSTTRAUMATIC-STRESS-DISORDER; CELL-MEDIATED-IMMUNITY;
   CORONARY-HEART-DISEASE; EXPOSURE THERAPY; GLUTAMATE RECEPTORS;
   ALZHEIMERS-DISEASE; METABOLIC SYNDROME; VIETNAM VETERANS;
   CONTROLLED-TRIAL; POTENTIAL ROLE
AB D-cycloserine (DCS) has been shown to be effective in facilitating fear extinction in animal and human studies, however the precise mechanisms whereby the co-administration of DCS and behavioural fear extinction reduce fear are still unclear. This study investigated the molecular mechanisms of intrahippocampally administered D-cycloserine in facilitating fear extinction in a contextual fear conditioning animal model. Male Sprague Dawley rats (n = 120) were grouped into four experimental groups (n = 30) based on fear conditioning and intrahippocampal administration of either DCS or saline. The light/dark avoidance test was used to differentiate maladapted (MA) (anxious) from well-adapted (WA) (not anxious) subgroups. RNA extracted from the left dorsal hippocampus was used for RNA sequencing and gene expression data was compared between six fear-conditioned + saline MA (FEAR + SALINE MA) and six fear-conditioned + DCS WA (FEAR + DCS WA) animals. Of the 424 significantly downregulated and 25 significantly upregulated genes identified in the FEAR + DCS WA group compared to the FEAR + SALINE MA group, 121 downregulated and nine upregulated genes were predicted to be relevant to fear conditioning and anxiety and stress-related disorders. The majority of downregulated genes transcribed immune, proinflammatory and oxidative stress systems molecules. These molecules mediate neuroinflammation and cause neuronal damage. DCS also regulated genes involved in learning and memory processes, and genes associated with anxiety, stress-related disorders and co-occurring diseases (e.g., cardiovascular diseases, digestive system diseases and nervous system diseases). Identifying the molecular underpinnings of DCS-mediated fear extinction brings us closer to understanding the process of fear extinction.
C1 [Malan-Mueller, Stefanie; Fairbairn, Lorren; Seedat, Soraya; Hemmings, Sian Megan Joanna] Univ Stellenbosch, Fac Med & Hlth Sci, Dept Psychiat, Cape Town, South Africa.
   [Daniels, Willie M. U.] Univ KwaZulu Natal, Dept Human Physiol, Durban, South Africa.
   [Dashti, Mahjoubeh Jalali Sefid; Gamieldien, Junaid] Univ Western Cape, South African Natl Bioinformat Inst, Cape Town, South Africa.
   [Oakeley, Edward J.; Altorfer, Marc] Novartis Inst BioMed Res, Biomarker Dev Human Genet & Genom Genome Technol, Basel, Switzerland.
   [Kidd, Martin] Univ Stellenbosch, Ctr Stat Consultat, ZA-7600 Stellenbosch, South Africa.
   [Malan-Mueller, Stefanie; Hemmings, Sian Megan Joanna] Univ Stellenbosch, Fac Med & Hlth Sci, DST NRF Ctr Excellence Biomed TB Res, SA MRC Ctr TB Res,Div Mol Biol & Human Genet, Cape Town, South Africa.
C3 Stellenbosch University; University of Kwazulu Natal; University of the
   Western Cape; Novartis; Stellenbosch University; Stellenbosch
   University; National Research Foundation - South Africa
RP Malan-Müller, S (corresponding author), Univ Stellenbosch, Fac Med & Hlth Sci, Dept Psychiat, Cape Town, South Africa.; Malan-Müller, S (corresponding author), Univ Stellenbosch, Fac Med & Hlth Sci, DST NRF Ctr Excellence Biomed TB Res, SA MRC Ctr TB Res,Div Mol Biol & Human Genet, Cape Town, South Africa.
EM smalan@sun.ac.za
RI Siabani, Soraya/U-7739-2017; Hemmings, Sian/ABF-9676-2022
OI Malan-Muller, Stefanie/0000-0003-0639-0129; Seedat,
   Soraya/0000-0002-5118-786X; Hemmings, Sian/0000-0001-8461-1017; Daniels,
   Willie/0000-0002-5881-4926
FU South African Research Chairs Initiative of Department of Science and
   Technology; National Research Foundation; South African Medical Research
   Council; Harry Crossley Foundation; Novartis Pharma AG of Basel,
   Switzerland
FX This work is based upon research supported by the South African Research
   Chairs Initiative of the Department of Science and Technology and
   National Research Foundation, South African Medical Research Council
   (self-initiated research grant) and Harry Crossley Foundation funding.
   We would also like to acknowledge Novartis Pharma AG of Basel,
   Switzerland for funding and performing all the library construction and
   next generation sequencing for this project.
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NR 127
TC 5
Z9 5
U1 0
U2 22
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0885-7490
EI 1573-7365
J9 METAB BRAIN DIS
JI Metab. Brain Dis.
PD FEB
PY 2016
VL 31
IS 1
SI SI
BP 135
EP 156
DI 10.1007/s11011-015-9727-4
PG 22
WC Endocrinology & Metabolism; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology
GA DB7XI
UT WOS:000368730100014
PM 26400817
DA 2025-06-11
ER

PT J
AU Reddy, NN
   Rao, NP
   Venkatasubramian, G
   Arasappa, R
   Behere, RV
   Divakaran, A
   Sivakumar, PT
   Gangadhar, BN
AF Reddy, Nalini N.
   Rao, Naren P.
   Venkatasubramian, Ganesan
   Arasappa, Rashmi
   Behere, Rishikesh V.
   Divakaran, Anjith
   Sivakumar, Palanimuthu T.
   Gangadhar, Bangalore N.
TI Rimonabant-induced catatonia in schizophrenia: A case report
SO OBESITY RESEARCH & CLINICAL PRACTICE
LA English
DT Article
DE Schizophrenia; Catatonia; Rimonabant; Metabolic syndrome; Obesity
ID PHARMACOLOGY; SIBUTRAMINE; CANNABIS; EFFICACY; OBESITY; SAFETY
AB Patients with psychiatric illness have higher rates of mortality and medical co-morbidity related to increased rates of diabetes mellitus and cardiovascular disease. Rimonabant, a cannabinoid receptor (CB1) antagonist, is an anti-obesity agent and decreases risk for metabolic syndrome. Though there are reports of rimonabant associated with adverse psychiatric events like depression, rimonabant-induced catatonia is not reported. In this first time report, we describe a patient with schizophrenia developing catatonia possibly due to rimonabant. (C) 2009 Asian Oceanian Association for the Study of Obesity. Published by Elsevier Ltd. All rights reserved.
C1 [Reddy, Nalini N.; Rao, Naren P.; Venkatasubramian, Ganesan; Arasappa, Rashmi; Behere, Rishikesh V.; Divakaran, Anjith; Sivakumar, Palanimuthu T.; Gangadhar, Bangalore N.] Natl Inst Mental Hlth & Neurosci, Metab Clin Psychiat, Dept Psychiat, Bangalore 560029, Karnataka, India.
C3 National Institute of Mental Health & Neurosciences - India
RP Venkatasubramian, G (corresponding author), Natl Inst Mental Hlth & Neurosci, Metab Clin Psychiat, Dept Psychiat, Hosur Rd, Bangalore 560029, Karnataka, India.
EM venkat.nimhans@yahoo.com
RI Rao, Naren/AFW-2595-2022; Arasappa, Rashmi/KRQ-0733-2024;
   Venkatasubramanian, Ganesan/AAD-9117-2019
OI Venkatasubramanian, Ganesan/0000-0002-0949-898X; Gangadhar,
   Bangalore/0000-0002-9887-6515; Arasappa, Rashmi/0000-0001-7864-8200;
   behere, rishikesh/0000-0002-2395-0792
CR [Anonymous], 2008, Florida Municipal Power Agency Press Release
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   *WHO IASO IOTF, 2000, RED OB ITS TREATM
NR 17
TC 0
Z9 1
U1 0
U2 5
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1871-403X
EI 1878-0318
J9 OBES RES CLIN PRACT
JI Obes. Res. Clin. Pract.
PD NOV
PY 2009
VL 3
IS 4
BP 237
EP 239
DI 10.1016/j.orcp.2009.04.002
PG 3
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 532SI
UT WOS:000272769500006
PM 24973151
DA 2025-06-11
ER

PT J
AU Pedrosa, MA
   Labandeira, CM
   Valenzuela, R
   Quijano, A
   Sanchez-Andrade, M
   Suarez-Quintanilla, JA
   Lanciego, JL
   Labandeira-Garcia, JL
   Rodriguez-Perez, AI
AF Pedrosa, Maria A.
   Labandeira, Carmen M.
   Valenzuela, Rita
   Quijano, Aloia
   Sanchez-Andrade, Marina
   Suarez-Quintanilla, Juan A.
   Lanciego, Jose L.
   Labandeira-Garcia, Jose L.
   Rodriguez-Perez, Ana I.
TI AT1 receptor autoantibodies mediate effects of metabolic syndrome on
   dopaminergic vulnerability
SO BRAIN BEHAVIOR AND IMMUNITY
LA English
DT Article
DE Autoimmunity; ACE2; Blood -brain-barrier; Diabetes;
   27-Hydroxycholesterol; Hypertension; Obesity; Neurodegeneration;
   Parkinson; Renin-angiotensin system
ID RENIN-ANGIOTENSIN SYSTEM; PARKINSONS-DISEASE; CELL-DEATH; AGONISTIC
   AUTOANTIBODIES; OXIDATIVE STRESS; AT(1) RECEPTOR; PREECLAMPSIA; LIGHT;
   ASSOCIATION; ACTIVATION
AB The metabolic syndrome has been associated to chronic peripheral inflammation and related with neuro-inflammation and neurodegeneration, including Parkinson's disease. However, the responsible mechanisms are unclear. Previous studies have involved the brain renin-angiotensin system in progression of Parkinson's disease and the angiotensin receptor type 1 (AT1) has been recently revealed as a major marker of dopaminergic vulnerability in humans. Dysregulation of tissue renin-angiotensin system is a key common mechanism for all major components of metabolic syndrome. Circulating AT1 agonistic autoantibodies have been observed in several inflammation-related peripheral processes, and activation of AT1 receptors of endothelial cells, dopa-minergic neurons and glial cells have been observed to disrupt endothelial blood-brain barrier and induce neurodegeneration, respectively. Using a rat model, we observed that metabolic syndrome induces overactivity of nigral pro-inflammatory renin-angiotensin system axis, leading to increase in oxidative stress and neuro-inflammation and enhancing dopaminergic neurodegeneration, which was inhibited by treatment with AT1 receptor blockers (ARBs). In rats, metabolic syndrome induced the increase in circulating levels of LIGHT and other major pro-inflammatory cytokines, and 27-hydroxycholesterol. Furthermore, the rats showed a significant increase in serum levels of proinflammatory AT1 and angiotensin converting enzyme 2 (ACE2) autoantibodies, which correlated with levels of several metabolic syndrome parameters. We also found AT1 and ACE2 autoan-tibodies in the CSF of these rats. Effects of circulating autoantibodies were confirmed by chronic infusion of AT1 autoantibodies, which induced blood-brain barrier disruption, an increase in the pro-inflammatory renin-angiotensin system activity in the substantia nigra and a significant enhancement in dopaminergic neuron death in two different rat models of Parkinson's disease. Observations in the rat models, were analyzed in a cohort of parkinsonian and non-parkinsonian patients with or without metabolic syndrome. Non-parkinsonian patients with metabolic syndrome showed significantly higher levels of AT1 autoantibodies than non-parkinsonian patients without metabolic syndrome. However, there was no significant difference between parkinsonian patients with metabolic syndrome or without metabolic syndrome, which showed higher levels of AT1 autoantibodies than non-parkinsonian controls. This is consistent with our recent studies, showing significant increase of AT1 and ACE2 autoantibodies in parkinsonian patients, which was related to dopaminergic degeneration and neuroinflammation. Altogether may lead to a vicious circle enhancing the progression of the disease that may be inhibited by strategies against production of these autoantibodies or AT1 receptor blockers (ARBs).
C1 [Pedrosa, Maria A.; Labandeira, Carmen M.; Valenzuela, Rita; Quijano, Aloia; Labandeira-Garcia, Jose L.; Rodriguez-Perez, Ana I.] Univ Santiago Compostela, Res Ctr Mol Med & Chron Dis CIMUS, IDIS, Santiago De Compostela, Spain.
   [Pedrosa, Maria A.; Valenzuela, Rita; Lanciego, Jose L.; Labandeira-Garcia, Jose L.; Rodriguez-Perez, Ana I.] Networking Res Ctr Neurodegenerat Dis CIBERNED, Madrid, Spain.
   [Labandeira, Carmen M.] Univ Hosp Complex, Hosp Alvaro Cunqueiro, Neurol Serv, Vigo, Spain.
   [Labandeira, Carmen M.] Univ Hosp Ourense Ourense, Neurol Serv, Orense, Spain.
   [Sanchez-Andrade, Marina] Univ Clin Hosp Santiago Compostela, Obstet Serv, Santiago De Compostela, Spain.
   [Suarez-Quintanilla, Juan A.] IDIS, Primary Hlth Care Unit Fontinas, Santiago De Compostela, Spain.
   [Lanciego, Jose L.] Univ Navarra, Neurosci Div, CIMA, Pamplona, Spain.
   [Labandeira-Garcia, Jose L.; Rodriguez-Perez, Ana I.] Univ Santiago Compostela, Res Ctr Mol Med & Chron Dis CIMUS, Santiago De Compostela 15782, Spain.
C3 Universidade de Santiago de Compostela; CIBERNED; Complexo Hospitalario
   Universitario de Santiago de Compostela; University of Navarra;
   Universidade de Santiago de Compostela
RP Labandeira-Garcia, JL; Rodriguez-Perez, AI (corresponding author), Univ Santiago Compostela, Res Ctr Mol Med & Chron Dis CIMUS, IDIS, Santiago De Compostela, Spain.; Labandeira-Garcia, JL; Rodriguez-Perez, AI (corresponding author), Networking Res Ctr Neurodegenerat Dis CIBERNED, Madrid, Spain.; Labandeira-Garcia, JL; Rodriguez-Perez, AI (corresponding author), Univ Santiago Compostela, Res Ctr Mol Med & Chron Dis CIMUS, Santiago De Compostela 15782, Spain.
EM joseluis.labandeira@usc.es; anai.rodriguez@usc.es
RI Pedrosa, Maria A/ABA-2393-2021; Perez, Ana/AAM-1198-2021; Quijano,
   Aloia/ABA-2398-2021; García, José/AAM-3097-2021; Lanciego,
   Jose/G-7759-2015
OI Labandeira-Garcia, Jose Luis/0000-0002-8243-9791; Novoa Perez, Maria
   Iria/0009-0002-6073-9520; Pedrosa/0000-0001-9553-8513; Quijano,
   Aloia/0000-0003-2289-8838; Rodriguez Perez, Ana
   Isabel/0000-0003-1354-8799; Labandeira Guerra, Carmen
   M./0000-0002-6274-5871; Aldrey Garcia, Maria Pilar/0009-0004-2253-1432;
   Sanchez-Andrade, Marina/0009-0008-8570-7019; Gianzo Quintela,
   Cristina/0009-0001-0012-0964
FU University Hospital Complex
FX We thank Dr. Antonio Koukoulis and Dr. Gema Alonso (Neurology Service,
   Hospital Alvaro Cunqueiro, University Hospital Complex, Vigo, Spain) for
   their valuable contribution to patient recruitment clinical evaluation.
   We thank Pilar Aldrey, Iria Novoa and Cristina Gianzo for their
   technical assistance. We thank Obstetric Service, University Clin-ical
   Hospital of Santiago de Compostela (Santiago de Compostela, Spain) , and
   Primary Health-Care Unit Fontin?as (Santiago de Compos-tela, Spain) for
   collaboration in sample collection. Biostatech (htt p://biostatech.com )
   for statistical assistance. We thank all the patients and their families
   for participating in this study.
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NR 92
TC 14
Z9 16
U1 2
U2 12
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0889-1591
EI 1090-2139
J9 BRAIN BEHAV IMMUN
JI Brain Behav. Immun.
PD FEB
PY 2023
VL 108
BP 255
EP 268
DI 10.1016/j.bbi.2022.12.009
EA DEC 2022
PG 14
WC Immunology; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Neurosciences & Neurology; Psychiatry
GA 7T1KN
UT WOS:000911206600001
PM 36535607
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Silvestrini, A
   Mancini, A
AF Silvestrini, Andrea
   Mancini, Antonio
TI The Double-Edged Sword of Total Antioxidant Capacity: Clinical
   Significance and Personal Experience
SO ANTIOXIDANTS
LA English
DT Review
DE distress; metabolic syndrome; infertility; oxidative stress; total
   antioxidant capacity
ID GROWTH-HORMONE DEFICIENCY; CAUSE-SPECIFIC MORTALITY; C-REACTIVE PROTEIN;
   OXIDATIVE STRESS; URIC-ACID; CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME;
   OBESE CHILDREN; DNA-DAMAGE; ALL-CAUSE
AB Oxidative stress (OS) could be a condition underlying several human diseases, despite the physiological role of reactive oxygen species (oxidative eustress). Therefore, antioxidant compounds could represent a modulatory mechanism for maintaining a proper redox balance and redox signaling. When antioxidants are insufficient or overwhelmed, OS ensues, causing multiple damages at molecular, tissue, and cellular levels. This study focuses on the role of total antioxidant capacity (TAC) as a biomarker to be interpreted according to several clinical scenarios. After a brief description of various assay methods to elucidate terminology and physiopathological roles, we focus on the hormonal influence on TAC in blood plasma and other biological fluids, as different endocrine systems can modulate the antioxidant response. Furthermore, OS characterizes several endocrinopathies through different mechanisms: an inadequate antioxidant response to an increase in reducing equivalents (reductive distress) or a marked consumption of antioxidants (oxidative distress), which leads to low TAC values. An increased TAC could instead represent an adaptive mechanism, suggesting a situation of OS. Hence, the clinical context is fundamental for a correct interpretation of TAC. This review aims to provide the reader with a general overview of oxidative stress in several clinical examples of endocrine relevance, such as metabolic syndrome, non-thyroid illness syndrome, hypopituitarism, and infertility. Finally, the impact of dietary and surgical interventions on TAC in the model of metabolic syndrome is highlighted, along with personal experience.
C1 [Silvestrini, Andrea] Univ Cattolica Sacro Cuore, Dipartimento Sci Biotecnol Base Clin Intensivol &, I-00168 Rome, Italy.
   [Mancini, Antonio] Univ Cattolica Sacro Cuore, Dipartimento Med & Chirurg Traslaz, Largo Francesco Vito 1, I-00168 Rome, Italy.
C3 Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli;
   Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli
RP Silvestrini, A (corresponding author), Univ Cattolica Sacro Cuore, Dipartimento Sci Biotecnol Base Clin Intensivol &, I-00168 Rome, Italy.; Mancini, A (corresponding author), Univ Cattolica Sacro Cuore, Dipartimento Med & Chirurg Traslaz, Largo Francesco Vito 1, I-00168 Rome, Italy.
EM andrea.silvestrini@unicatt.it; antonio.mancini@unicatt.it
RI Silvestrini, Andrea/B-3410-2009
OI Silvestrini, Andrea/0000-0002-2005-3746
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NR 143
TC 2
Z9 2
U1 5
U2 8
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD AUG
PY 2024
VL 13
IS 8
AR 933
DI 10.3390/antiox13080933
PG 19
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA E9G1J
UT WOS:001306002100001
PM 39199179
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Gaggini, M
   Fenizia, S
   Vassalle, C
AF Gaggini, Melania
   Fenizia, Simona
   Vassalle, Cristina
TI Sphingolipid Levels and Signaling via Resveratrol and Antioxidant
   Actions in Cardiometabolic Risk and Disease
SO ANTIOXIDANTS
LA English
DT Review
DE resveratrol; sphingolipids; ceramides; sphingosine-1-phosphate;
   cardiometabolic risk; cardiometabolic disease
ID LOW-DENSITY-LIPOPROTEIN; CORONARY-ARTERY-DISEASE; NF-KAPPA-B;
   ENDOTHELIAL-CELLS; PLASMA CERAMIDES; CANCER CELLS; APOPTOSIS;
   SPHINGOSINE-1-PHOSPHATE; METABOLISM; PROTECTS
AB Resveratrol (RSV) is a phenolic compound with strong antioxidant activity, which is generally associated with the beneficial effects of wine on human health. All resveratrol-mediated benefits exerted on different systems and pathophysiological conditions are possible through resveratrol's interactions with different biological targets, along with its involvement in several key cellular pathways affecting cardiometabolic (CM) health. With regard to its role in oxidative stress, RSV exerts its antioxidant activity not only as a free radical scavenger but also by increasing the activity of antioxidant enzymes and regulating redox genes, nitric oxide bioavailability and mitochondrial function. Moreover, several studies have demonstrated that some RSV effects are mediated by changes in sphingolipids, a class of biolipids involved in a number of cellular functions (e.g., apoptosis, cell proliferation, oxidative stress and inflammation) that have attracted interest as emerging critical determinants of CM risk and disease. Accordingly, this review aimed to discuss the available data regarding the effects of RSV on sphingolipid metabolism and signaling in CM risk and disease, focusing on oxidative stress/inflammatory-related aspects, and the clinical implications of this relationship.
C1 [Gaggini, Melania; Fenizia, Simona] Natl Res Council Italy CNR, Inst Clin Physiol, Via Moruzzi 1, I-56124 Pisa, Italy.
   [Vassalle, Cristina] Fdn G Monasterio CNR Reg Toscana, Via Moruzzi 1, I-56124 Pisa, Italy.
C3 Consiglio Nazionale delle Ricerche (CNR); Istituto di Fisiologia Clinica
   (IFC-CNR)
RP Vassalle, C (corresponding author), Fdn G Monasterio CNR Reg Toscana, Via Moruzzi 1, I-56124 Pisa, Italy.
EM melania.gaggini@ifc.cnr.it; simona.fenizia@ifc.cnr.it;
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RI Fenizia, Simona/KPB-2675-2024; Gaggini, Melania/C-9379-2017
OI VASSALLE, CRISTINA/0000-0003-3438-6450; Fenizia,
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NR 128
TC 10
Z9 10
U1 0
U2 7
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD MAY 16
PY 2023
VL 12
IS 5
AR 1102
DI 10.3390/antiox12051102
PG 16
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA H4EB7
UT WOS:000995502700001
PM 37237968
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Madani, M
   Madani, FM
   Frank, M
AF Madani, Mansoor
   Madani, Farideh M.
   Frank, Marcella
TI Psychological Issues in Sleep Apnea
SO ORAL AND MAXILLOFACIAL SURGERY CLINICS OF NORTH AMERICA
LA English
DT Article
DE Sleep apnea; Sleep-disordered breathing; Depression; Mood; Affective
   disorders
ID POSITIVE AIRWAY PRESSURE; QUALITY-OF-LIFE; METABOLIC SYNDROME;
   APNOEA/HYPOPNOEA SYNDROME; DEPRESSIVE SYMPTOMS; INSULIN-RESISTANCE;
   COGNITIVE FUNCTION; HYPOPNEA SYNDROME; DAYTIME FUNCTION; CPAP TREATMENT
AB The overlap of sleep disorders with various psychiatric problems is so great that one would suspect that both types of problems may have common biologic roots. An estimated 65% to 90% of adults with major depression experience some kind of sleep problem. Sleep problems also increase the risk for developing depression. Since the early days of research on disturbed sleep, clinical studies have suggested the existence of a relationship between depression and obstructive sleep apnea.
C1 [Madani, Mansoor] Bala Inst Oral & Facial Surg, Bala Cynwyd, PA 19004 USA.
   [Madani, Mansoor] Capital Hlth Reg Med Ctr, Dept Oral & Maxillofacial Surg, Trenton, NJ 08638 USA.
   [Madani, Mansoor] Temple Univ, Philadelphia, PA 19140 USA.
   [Madani, Farideh M.] Univ Penn, Sch Dent Med, Dept Oral Med, Robert Schattner Ctr, Philadelphia, PA 19104 USA.
   [Frank, Marcella] Capital Hlth Ctr Sleep Med, Ctr Sleep Med, Trenton, NJ 08638 USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE); Temple
   University; University of Pennsylvania
RP Madani, M (corresponding author), Bala Inst Oral & Facial Surg, 15 N Presidential Blvd,Suite 301, Bala Cynwyd, PA 19004 USA.
EM drmmadani@gmail.com
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NR 58
TC 4
Z9 5
U1 0
U2 6
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 1042-3699
EI 1558-1365
J9 ORAL MAXIL SURG CLIN
JI Oral Maxillofac. Surg. Clin. N. Am.
PD NOV
PY 2010
VL 22
IS 4
BP 503
EP +
DI 10.1016/j.coms.2010.07.007
PG 8
WC Dentistry, Oral Surgery & Medicine
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dentistry, Oral Surgery & Medicine
GA 864TX
UT WOS:000298264100010
PM 20970716
DA 2025-06-11
ER

PT J
AU Papakyriakopoulou, P
   Velidakis, N
   Khattab, E
   Valsami, G
   Korakianitis, I
   Kadoglou, NP
AF Papakyriakopoulou, Paraskevi
   Velidakis, Nikolaos
   Khattab, Elina
   Valsami, Georgia
   Korakianitis, Ioannis
   Kadoglou, Nikolaos Pe
TI Potential Pharmaceutical Applications of Quercetin in Cardiovascular
   Diseases
SO PHARMACEUTICALS
LA English
DT Review
DE quercetin; cardiovascular diseases; diabetes mellitus; hypertension;
   dyslipidemia
ID ANGIOTENSIN-CONVERTING ENZYME; ACTIVATED PROTEIN-KINASE; BLOOD-PRESSURE;
   IN-VITRO; ENDOTHELIAL DYSFUNCTION; INDUCED ATHEROSCLEROSIS; PROTECTIVE
   AUTOPHAGY; METABOLIC SYNDROME; OXIDATIVE STRESS; GLUCOSE-UPTAKE
AB Quercetin, as a member of flavonoids, has emerged as a potential therapeutic agent in cardiovascular diseases (CVDs) in recent decades. In this comprehensive literature review, our goal was a critical appraisal of the pathophysiological mechanisms of quercetin in relation to the classical cardiovascular risk factors (e.g., hyperlipidemia), atherosclerosis, etc. We also assessed experimental and clinical data about its potential application in CVDs. Experimental studies including both in vitro methods and in vivo animal models mainly outline the following effects of quercetin: (1) antihypertensive, (2) hypolipidemic, (3) hypoglycemic, (4) anti-atherosclerotic, and (5) cardioprotective (suppressed cardiotoxicity). From the clinical point of view, there are human studies and meta-analyses implicating its beneficial effects on glycemic and lipid parameters. In contrast, other human studies failed to demonstrate consistent favorable effects of quercetin on other cardiometabolic risk factors such as MS, obesity, and hypertension, underlying the need for further investigation. Analyzing the reason of this inconsistency, we identified significant drawbacks in the clinical trials' design, while the absence of pharmacokinetic/pharmacodynamic tests prior to the studies attenuated the power of clinical results. Therefore, additional well-designed preclinical and clinical studies are required to examine the therapeutic mechanisms and clinical efficacy of quercetin in CVDs.
C1 [Papakyriakopoulou, Paraskevi; Valsami, Georgia] Natl & Kapodistrian Univ Athens, Sch Hlth Sci, Dept Pharm, Lab Biopharmaceut Pharmacokinet, Athens 15784, Greece.
   [Velidakis, Nikolaos; Khattab, Elina; Korakianitis, Ioannis; Kadoglou, Nikolaos Pe] Univ Cyprus, Med Sch, CY-2029 Nicosia, Cyprus.
C3 National & Kapodistrian University of Athens; University of Cyprus
RP Korakianitis, I (corresponding author), Univ Cyprus, Med Sch, CY-2029 Nicosia, Cyprus.
EM korakianitis.ioannis@ucy.ac.cy
RI Khattab, Elina/KIH-9138-2024; Velidakis, Nikolaos/HJP-3776-2023;
   Kadoglou, Nikolaos/AAA-8639-2021; Valsami, Georgia/AAB-4710-2020
OI Valsami, Georgia/0000-0002-2395-6844; Papakyriakopoulou,
   Paraskevi/0000-0003-0566-0713; Velidakis, Nikolaos/0000-0002-1909-0048
FU University of Cyprus
FX We thank University of Cyprus for supporting the publication of the
   present paper.
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NR 156
TC 49
Z9 51
U1 4
U2 33
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1424-8247
J9 PHARMACEUTICALS-BASE
JI Pharmaceuticals
PD AUG
PY 2022
VL 15
IS 8
AR 1019
DI 10.3390/ph15081019
PG 23
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 4B5MW
UT WOS:000845822300001
PM 36015169
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Mehra, A
   Suri, V
   Kumari, S
   Avasthi, A
   Grover, S
AF Mehra, Aseem
   Suri, Vikas
   Kumari, Savita
   Avasthi, Ajit
   Grover, Sandeep
TI Association of mild cognitive impairment and metabolic syndrome in
   patients with hypertension
SO ASIAN JOURNAL OF PSYCHIATRY
LA English
DT Article
DE Hypertension; Metabolic syndrome; Cognitive decline; Mild cognitive
   impairment
ID VASCULAR RISK-FACTORS; MIDLIFE BLOOD-PRESSURE; ALZHEIMERS-DISEASE;
   LATE-LIFE; INSULIN-RESISTANCE; FOLLOW-UP; DEMENTIA; DECLINE; POPULATION;
   OBESITY
AB Aim: The aim of this study was to evaluate the prevalence of mild cognitive impairment (MCI) in patients with hypertension and to evaluate the association of MCI with metabolic syndrome (MetS).
   Methodology: 186 subjects with hypertension were evaluated on Montreal Cognitive Assessment (MoCA) and Patient Health Questionnaire (PHQ-9) for cognitive decline and depression, respectively and MetS was diagnosed as per the Consensus definition.
   Results: The prevalence of MCI was 65.6 % and that of MetS was 45.7%. Compared to those without MetS, those with MetS had significantly poorer cognitive functioning on the all cognitive domain of the MoCA, even after controlling for age, education, severity of the depression and duration of illness. Low High-Density Lipoprotein (HDL) was found to have a positive correlation with MoCA. Higher age, lower education, higher duration of illness and use of higher numbers of medications were associated with significantly lower score on MoCA.
   Conclusion: Presence of MetS among persons with hypertension is associated with cognitive decline. Hence, there is a need to monitor and manage other parameters of MetS among patients with hypertension, to reduce the risk of cognitive decline and future dementia.
C1 [Mehra, Aseem; Avasthi, Ajit; Grover, Sandeep] Post Grad Inst Med Educ & Res, Dept Psychiat, Chandigarh 160012, India.
   [Suri, Vikas; Kumari, Savita] Post Grad Inst Med Educ & Res, Dept Internal Med, Chandigarh 160012, India.
C3 Post Graduate Institute of Medical Education & Research (PGIMER),
   Chandigarh; Post Graduate Institute of Medical Education & Research
   (PGIMER), Chandigarh
RP Grover, S (corresponding author), Post Grad Inst Med Educ & Res, Dept Psychiat, Chandigarh 160012, India.
EM aseemmehra86@gmail.com; surivikas9479@gmail.com; savita349@yahoo.com;
   drajitavasthi@yahoo.co.in; drsandeepg2002@yahoo.com
OI Grover, Sandeep/0000-0002-2714-2055
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NR 90
TC 10
Z9 10
U1 0
U2 9
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1876-2018
EI 1876-2026
J9 ASIAN J PSYCHIATR
JI Asian J. Psychiatr.
PD OCT
PY 2020
VL 53
AR 102185
DI 10.1016/j.ajp.2020.102185
PG 7
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychiatry
GA PA8ZV
UT WOS:000595918300052
PM 32540752
DA 2025-06-11
ER

PT J
AU Wingenfeld, K
   Kuehl, LK
   Boeker, A
   Schultebraucks, K
   Ritter, K
   Hellmann-Regen, J
   Otte, C
   Spitzer, C
AF Wingenfeld, Katja
   Kuehl, Linn K.
   Boeker, Anita
   Schultebraucks, Katharina
   Ritter, Kristin
   Hellmann-Regen, Julian
   Otte, Christian
   Spitzer, Carsten
TI Stress reactivity and its effects on subsequent food intake in depressed
   and healthy women with and without adverse childhood experiences
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE Adverse childhood experiences; Depression; Stress; Cortisol; Eating
   behavior
ID CORTICOTROPIN-RELEASING-FACTOR; HPA AXIS RESPONSE; PSYCHOSOCIAL STRESS;
   CORTISOL RESPONSES; ADRENALECTOMIZED RATS; SUCROSE INGESTION; MAJOR
   DEPRESSION; EATING BEHAVIOR; PHYSICAL ABUSE; DISORDER
AB Background: Adverse childhood experiences (ACE) increase the risk to develop major depressive disorder (MDD) and obesity or metabolic syndrome in adulthood. In addition, ACE may be associated with an exaggerated endocrine response to stress, which, in turn, may lead to enhanced food intake resulting in obesity and metabolic problems.
   Methods: We systematically examined the stress response and consecutive food intake in 32 women with MDD and ACE as determined by a clinical interview (Early Trauma Inventory), 52 women with MDD without ACE, 22 women with ACE but no current or lifetime MDD and 37 healthy women without either MDD or ACE. All participants underwent a psychosocial stress test (Trier Social Stress Test, TSST) and a control condition (Placebo-TSST) before they were offered a buffet of snacks. Participants were not aware that the primary outcome variable was the amount of consumed kilocalories (kcal).
   Results: The four groups did not differ in demographic variables. Stress resulted in higher cortisol release and higher blood pressure compared to the control condition. Patients with MDD without ACE had a significantly lower cortisol response to stress compared to controls. Across groups, we found higher kcal intake after stress compared to the control condition. Comparing high and low cortisol responders to stress, higher kcal intake after stress was only seen in those with low cortisol release.
   Conclusions: This study provides evidence that blunted rather than enhanced cortisol release to stress might lead to increased food intake, independent from MDD and ACE. (C) 2017 Elsevier Ltd. All rights reserved.
C1 [Wingenfeld, Katja; Kuehl, Linn K.; Schultebraucks, Katharina; Ritter, Kristin; Hellmann-Regen, Julian; Otte, Christian] Charite Univ Med Berlin, Dept Psychiat & Psychotherapy, Campus Benjamin Franklin,Hindenburgdamm 30, D-12203 Berlin, Germany.
   [Boeker, Anita; Spitzer, Carsten] Asklepios Fachklinikun Tiefenbrunn, Rosdorf, Germany.
C3 Berlin Institute of Health; Free University of Berlin; Humboldt
   University of Berlin; Charite Universitatsmedizin Berlin
RP Wingenfeld, K (corresponding author), Charite Univ Med Berlin, Dept Psychiat & Psychotherapy, Campus Benjamin Franklin,Hindenburgdamm 30, D-12203 Berlin, Germany.
EM katja.wingenfeld@charite.de
RI Schultebraucks, Katharina/J-7216-2019
OI Wingenfeld, Katja/0000-0001-7457-0370; Schultebraucks,
   Katharina/0000-0001-5085-8249; Kuehl, Linn/0000-0001-6871-6302; Otte,
   Christian/0000-0002-4051-997X
FU Deutsche Forschungsgemeinschaft [WI 3396/6-1, SP 579/3-1]
FX The study was supported by grant of the Deutsche Forschungsgemeinschaft
   (WI 3396/6-1 & SP 579/3-1) awarded to KW, CS and CO.
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NR 51
TC 27
Z9 35
U1 0
U2 17
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD JUN
PY 2017
VL 80
BP 122
EP 130
DI 10.1016/j.psyneuen.2017.03.014
PG 9
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA EW2UT
UT WOS:000402352200016
PM 28324701
DA 2025-06-11
ER

PT J
AU Morine, MJ
   O'Brien, C
   Roche, HM
AF Morine, Melissa J.
   O'Brien, Cathal
   Roche, Helen M.
TI Transcriptomic signatures that have identified key features of metabolic
   syndrome
SO PROCEEDINGS OF THE NUTRITION SOCIETY
LA English
DT Article; Proceedings Paper
CT Symposium on the Challenge of Translating Nutrition Research into Public
   Health Nutrition
CY JUN 18-20, 2008
CL Univ Coll Dublin, OReilly Hall, Dublin, IRELAND
HO Univ Coll Dublin, OReilly Hall
DE Nutrigenomics; Transcriptomic signatures; Metabolic syndrome
ID SUBCUTANEOUS ADIPOSE-TISSUE; TYPE-2 DIABETES-MELLITUS; GENE-EXPRESSION
   PROFILE; SKELETAL-MUSCLE; FATTY-ACIDS; OXIDATIVE STRESS; MICROARRAY
   DATA; GAMMA COACTIVATOR-1; INSULIN SENSITIVITY; MONONUCLEAR-CELLS
AB The Human Genome Project and rapid advances in high-throughput molecular technologies are providing an unprecedented opportunity to advance the understanding of the common polygenic diet-related diseases, including obesity, the metabolic syndrome, type 2 diabetes mellitus, CVD and some cancers. In particular, transcriptomic approaches that allow multiple simultaneous gene-expression profiles facilitate the characterisation of metabolic perturbations that underlie diet-related pathologies. The present paper will focus on 'transcriptomic signatures' to characterise and understand the molecular mechanisms that accurately reflect 'metabolic health'.
C1 [Morine, Melissa J.; O'Brien, Cathal; Roche, Helen M.] Univ Coll Dublin, Nutrigenom Res Grp, Sch Publ Hlth & Populat Sci, Conway Inst, Dublin 4, Ireland.
C3 University College Dublin
RP Roche, HM (corresponding author), Univ Coll Dublin, Nutrigenom Res Grp, Sch Publ Hlth & Populat Sci, Conway Inst, Dublin 4, Ireland.
EM helen.roche@ucd.ie
RI O'Brien, Cathal/AAV-4672-2021; Roche, Helen/AAF-4164-2019
OI Roche, Helen/0000-0002-0628-3318; O'Brien, Cathal/0000-0001-9099-7462
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NR 44
TC 2
Z9 2
U1 0
U2 6
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0029-6651
EI 1475-2719
J9 P NUTR SOC
JI Proc. Nutr. Soc.
PD NOV
PY 2008
VL 67
IS 4
BP 395
EP 403
DI 10.1017/S0029665108008756
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Nutrition & Dietetics
GA 370QI
UT WOS:000260777200009
PM 18847516
OA Bronze
DA 2025-06-11
ER

PT J
AU Hulsmans, M
   Geeraert, B
   De Keyzer, D
   Mertens, A
   Lannoo, M
   Vanaudenaerde, B
   Hoylaerts, M
   Benhabilès, N
   Tsatsanis, C
   Mathieu, C
   Holvoet, P
AF Hulsmans, Maarten
   Geeraert, Benjamine
   De Keyzer, Dieuwke
   Mertens, Ann
   Lannoo, Matthias
   Vanaudenaerde, Bart
   Hoylaerts, Marc
   Benhabiles, Nora
   Tsatsanis, Christos
   Mathieu, Chantal
   Holvoet, Paul
TI Interleukin-1 Receptor-Associated Kinase-3 Is a Key Inhibitor of
   Inflammation in Obesity and Metabolic Syndrome
SO PLOS ONE
LA English
DT Article
ID LOW-DENSITY-LIPOPROTEIN; IRAK-M; CARDIOVASCULAR-DISEASE;
   MYOCARDIAL-INFARCTION; OXIDATIVE STRESS; ADIPONECTIN; EXPRESSION;
   MONOCYTES; RISK; MACROPHAGES
AB Background: Visceral obesity is associated with the rising incidence of type 2 diabetes and metabolic syndrome. Low-grade chronic inflammation and oxidative stress synergize in obesity and obesity-induced disorders.
   Objective: We searched a cluster of molecules that support interactions between these stress conditions in monocytes.
   Methods: RNA expressions in blood monocytes of two independent cohorts comprising 21 and 102 obese persons and 46 age-matched controls were determined by microarray and independently validated by quantitative RT-PCR analysis. The effect of three-month weight loss after bariatric surgery was determined. The effect of RNA silencing on inflammation and oxidative stress was studied in human monocytic THP-1 cells.
   Results: Interleukin-1 receptor-associated kinase-3 (IRAK3), key inhibitor of IRAK/NF kappa B-mediated chronic inflammation, is downregulated in monocytes of obese persons. Low IRAK3 was associated with high superoxide dismutase-2 (SOD2), a marker of mitochondrial oxidative stress. A comparable expression profile was also detected in visceral adipose tissue of the same obese subjects. Low IRAK3 and high SOD2 was associated with a high prevalence of metabolic syndrome (odds ratio: 9.3; sensitivity: 91%; specificity: 77%). By comparison, the odds ratio of high-sensitivity C-reactive protein, a widely used marker of systemic inflammation, was 4.3 (sensitivity: 69%; specificity: 66%). Weight loss was associated with an increase in IRAK3 and a decrease in SOD2, in association with a lowering of systemic inflammation and a decreasing number of metabolic syndrome components. We identified the increase in reactive oxygen species in combination with obesity-associated low adiponectin and high glucose and interleukin-6 as cause of the decrease in IRAK3 in THP-1 cells in vitro.
   Conclusion: IRAK3 is a key inhibitor of inflammation in association with obesity and metabolic syndrome. Our data warrant further evaluation of IRAK3 as a diagnostic and prognostic marker, and as a target for intervention.
C1 [Hulsmans, Maarten; Geeraert, Benjamine; De Keyzer, Dieuwke; Benhabiles, Nora; Holvoet, Paul] Katholieke Univ Leuven, Dept Cardiovasc Dis, Atherosclerosis & Metab Unit, Louvain, Belgium.
   [Mertens, Ann; Mathieu, Chantal] Katholieke Univ Leuven, Dept Expt Med, Expt Med & Endocrinol Sect, Louvain, Belgium.
   [Lannoo, Matthias] Katholieke Univ Leuven, Div Abdominal Surg, Louvain, Belgium.
   [Vanaudenaerde, Bart] Katholieke Univ Leuven, Dept Pathophysiol, Pneumol Sect, Louvain, Belgium.
   [Hoylaerts, Marc] Katholieke Univ Leuven, Dept Mol & Cellular Med, Ctr Mol & Vasc Biol, Louvain, Belgium.
   [Tsatsanis, Christos] Univ Crete, Sch Med, Dept Clin Chem, Iraklion, Greece.
C3 KU Leuven; KU Leuven; KU Leuven; KU Leuven; KU Leuven; University of
   Crete
RP Hulsmans, M (corresponding author), Katholieke Univ Leuven, Dept Cardiovasc Dis, Atherosclerosis & Metab Unit, Louvain, Belgium.
EM paul.holvoet@med.kuleuven.be
RI Tsatsanis, Christos/AAM-9362-2020; HOLVOET, PAUL/T-8434-2017; Hulsmans,
   Maarten/AAI-9547-2020; mathieu, chantal/ABD-5505-2021; lannoo,
   matthias/AAB-1706-2020; Tsatsanis, Christos/C-2516-2018
OI Vanaudenaerde, Bart/0000-0001-6435-6901; Mertens,
   Ann/0000-0002-1649-4311; Hulsmans, Maarten/0000-0003-1009-658X;
   Hoylaerts, Marc/0000-0002-6474-3933; Holvoet, Paul/0000-0001-9201-0772;
   Tsatsanis, Christos/0000-0003-1214-4151; Lannoo,
   matthias/0000-0001-7815-1157; Mathieu, Chantal/0000-0002-4055-5233
FU Belgian Federal Government [P06/30]; Bijzonder Onderzoeksfonds of the
   Katholieke Universiteit Leuven [OT/06/56, PF/10/014]; Fonds voor
   Wetenschappelijk Onderzoek-Vlaanderen [G.0548.08, G0846.11]
FX Funding was provided by the Interuniversitaire Attractiepolen Programma
   of the Belgian Federal Government (P06/30), the Bijzonder
   Onderzoeksfonds of the Katholieke Universiteit Leuven (OT/06/56 and
   PF/10/014) and by the Fonds voor Wetenschappelijk Onderzoek-Vlaanderen
   (G.0548.08, G0846.11, and Vascular Biology Network). The funders had no
   role in study design, data collection and analysis, decision to publish,
   or preparation of the manuscript.
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NR 42
TC 65
Z9 70
U1 1
U2 7
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JAN 17
PY 2012
VL 7
IS 1
AR e30414
DI 10.1371/journal.pone.0030414
PG 11
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 907XU
UT WOS:000301454400124
PM 22272346
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Smari, UJ
   Valdimarsdottir, UA
   Aspelund, T
   Hauksdottir, A
   Thordardottir, EB
   Hartman, CA
   Andell, P
   Larsson, H
   Zoega, H
AF Smari, Unnur Jakobsdottir
   Valdimarsdottir, Unnur Anna
   Aspelund, Thor
   Hauksdottir, Arna
   Thordardottir, Edda Bjork
   Hartman, Catharina A.
   Andell, Pontus
   Larsson, Henrik
   Zoega, Helga
TI Psychiatric comorbidities in women with cardiometabolic conditions with
   and without ADHD: a population-based study
SO BMC MEDICINE
LA English
DT Article
DE Attention-deficit/hyperactivity disorder; Females; Cardiometabolic risk
   factors; Cardiovascular diseases; Type 2 diabetes; Hypertension;
   Obesity; Anxiety disorders; Mood disorders; Self-harm
ID ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; WORLD-HEALTH-ORGANIZATION;
   DEPRESSION; OBESITY; RISK; ADULTS; METAANALYSIS; SYMPTOMS
AB BackgroundLeveraging a large nationwide study of Icelandic women, we aimed to narrow the evidence gap around female attention-deficit/hyperactivity disorder (ADHD) and cardiometabolic comorbidities by determining the prevalence of obesity, hypertension, type 2 diabetes, and cardiovascular diseases among women with ADHD and examine the association between cardiometabolic conditions and co-occurring ADHD with anxiety and mood disorders, alcoholism/substance use disorder (SUD), self-harm, and suicide attempts.MethodsWe conducted a cross-sectional analysis of the nationwide, all-female, population-based SAGA Cohort Study (n = 26,668). To ascertain diagnoses and symptoms, we used self-reported history of ADHD diagnoses, selected cardiometabolic conditions and psychiatric disorders, and measured current depressive, anxiety, and PTSD symptoms through appropriate questionnaires (PHQ-9, GAD-7, and PCL-5). We calculated age-adjusted prevalences of cardiometabolic conditions by women's ADHD status and estimated adjusted prevalence ratios (PR) and 95% confidence intervals (CI), using modified Poisson regression models. Similarly, we assessed the association of cardiometabolic conditions and co-occurring ADHD with current psychiatric symptoms and psychiatric disorders, using adjusted PRs and 95% CIs.ResultsWe identified 2299 (8.6%) women with a history of ADHD diagnosis. The age-adjusted prevalence of having at least one cardiometabolic condition was higher among women with ADHD (49.5%) than those without (41.7%), (PR = 1.19, 95% CI 1.14-1.25), with higher prevalence of all measured cardiometabolic conditions (myocardial infarctions (PR = 2.53, 95% CI 1.83--3.49), type 2 diabetes (PR = 2.08, 95% CI 1.66-2.61), hypertension (PR = 1.23, 95% CI 1.12-1.34), and obesity (PR = 1.18, 95% CI 1.11-1.25)). Women with cardiometabolic conditions and co-occurring ADHD had, compared with those without ADHD, substantially increased prevalence of (a) all measured mood and anxiety disorders, e.g., depression (PR = 2.38, 95% CI 2.19-2.58), bipolar disorder (PR = 4.81, 95% CI 3.65-6.35), posttraumatic stress disorder (PR = 2.78, 95% CI 2.52-3.07), social phobia (PR = 2.96, 95% CI 2.64-3.32); (b) moderate/severe depressive, anxiety, and PTSD symptoms with PR = 1.76 (95% CI 1.67-1.85), PR = 1.97 (95% CI 1.82-2.12), and PR = 2.01 (95% CI 1.88-2.15), respectively; (c) alcoholism/SUD, PR = 4.79 (95% CI 3.90-5.89); and (d) self-harm, PR = 1.47 (95% CI 1.29-1.67) and suicide attempts, PR = 2.37 (95% CI 2.05-2.73).ConclusionsADHD is overrepresented among women with cardiometabolic conditions and contributes substantially to other psychiatric comorbidities among women with cardiometabolic conditions.
C1 [Smari, Unnur Jakobsdottir; Valdimarsdottir, Unnur Anna; Aspelund, Thor; Hauksdottir, Arna; Thordardottir, Edda Bjork; Zoega, Helga] Univ Iceland, Fac Med, Ctr Publ Hlth Sci, Sturlugata 8, IS-102 Reykjavik, Iceland.
   [Valdimarsdottir, Unnur Anna] Karolinska Inst, Unit Integrat Epidemiol, Inst Environm Med, Stockholm, Sweden.
   [Valdimarsdottir, Unnur Anna] Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA.
   [Thordardottir, Edda Bjork] Natl Univ Hosp Iceland, Mental Hlth Serv, Landspitali, Reykjavik, Iceland.
   [Hartman, Catharina A.] Univ Groningen, Univ Med Ctr Groningen, Interdisciplinary Ctr Psychopathol & Emot Regulat, Dept Psychiat, Groningen, Netherlands.
   [Andell, Pontus] Karolinska Inst, Unit Cardiol, Dept Med, Heart & Vasc Div,Karolinska Univ Hosp, Stockholm, Sweden.
   [Larsson, Henrik] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.
   [Larsson, Henrik] Orebro Univ, Sch Med Sci, Orebro, Sweden.
   [Zoega, Helga] UNSW Sydney, Fac Med & Hlth, Sch Populat Hlth, Sydney, NSW, Australia.
C3 University of Iceland; Karolinska Institutet; Harvard University;
   Harvard T.H. Chan School of Public Health; University of Groningen;
   Karolinska Institutet; Karolinska University Hospital; Karolinska
   Institutet; Orebro University; University of New South Wales Sydney
RP Smari, UJ (corresponding author), Univ Iceland, Fac Med, Ctr Publ Hlth Sci, Sturlugata 8, IS-102 Reykjavik, Iceland.
EM ujsmari@hi.is
RI Thordardottir, Edda/IUO-4848-2023; Zoega, Helga/M-1968-2015; Andell,
   Pontus/ITU-4503-2023; Aspelund, Thor/C-5983-2008; Larsson,
   Henrik/GYD-5161-2022; Andell, Pontus/N-9979-2014
OI Larsson, Henrik/0000-0002-6851-3297; Thordardottir, Edda
   Bjork/0000-0003-3775-9611; Zoega, Helga/0000-0003-0761-9028; Andell,
   Pontus/0000-0002-2759-1379; Jakobsdottir Smari,
   Unnur/0009-0001-7151-9622
FU We are grateful to the SAGA cohort research team for conducting the
   study as well as to the women who participated.
FX We are grateful to the SAGA cohort research team for conducting the
   study as well as to the women who participated.
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NR 47
TC 1
Z9 1
U1 1
U2 2
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1741-7015
J9 BMC MED
JI BMC Med.
PD NOV 20
PY 2023
VL 21
IS 1
AR 450
DI 10.1186/s12916-023-03160-7
PG 10
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA Y3NC6
UT WOS:001104359400001
PM 37981673
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Brands, MW
AF Brands, Michael W.
TI Role of Insulin-Mediated Antinatriuresis in Sodium Homeostasis and
   Hypertension
SO HYPERTENSION
LA English
DT Review
ID INCREASES ARTERIAL-PRESSURE; ATRIAL-NATRIURETIC-FACTOR;
   RENIN-ANGIOTENSIN SYSTEM; SPRAGUE-DAWLEY RATS; BLOOD-PRESSURE; CHRONIC
   HYPERINSULINEMIA; METABOLIC SYNDROME; RENAL SODIUM; GLUCOSE-INFUSION;
   OXIDATIVE STRESS
C1 [Brands, Michael W.] Med Coll Georgia, Dept Physiol, Augusta, GA 30912 USA.
C3 University System of Georgia; Augusta University
RP Brands, MW (corresponding author), Augusta Univ, Dept Physiol, CA Med Coll Georgia 3098, Augusta, GA 30912 USA.
EM mbrands@augusta.edu
FU  [HL56259]
FX This work was supported by HL56259.
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NR 98
TC 36
Z9 35
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0194-911X
EI 1524-4563
J9 HYPERTENSION
JI Hypertension
PD DEC
PY 2018
VL 72
IS 6
BP 1255
EP 1262
DI 10.1161/HYPERTENSIONAHA.118.11728
PG 8
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA GZ4VT
UT WOS:000449404600004
PM 30571237
OA Bronze
DA 2025-06-11
ER

PT J
AU Jiménez-Fernandez, S
   Gurpegui, M
   Garrote-Rojas, DA
   Gutiérrez-Rojas, L
   Carretero, MD
   Correll, CU
AF Jimenez-Fernandez, Sara
   Gurpegui, Manuel
   Garrote-Rojas, D. aniel
   Gutierrez-Rojas, Luis
   Carretero, Maria D.
   Correll, Christoph U.
TI Oxidative stress parameters and antioxidants in patients with bipolar
   disorder: Results from a meta-analysis comparing patients, including
   stratification by polarity and euthymic status, with healthy controls
SO BIPOLAR DISORDERS
LA English
DT Review
DE antioxidants; bipolar disorder; meta-analysis; oxidative stress;
   polarity
ID METABOLIC SYNDROME; SPECTRUM DISORDER; GLOBAL BURDEN; FREE-RADICALS;
   NITRIC-OXIDE; PREVALENCE; DEPRESSION; MARKERS; LITHIUM; DISEASE
AB Objective To investigate oxidative stress markers and antioxidants in bipolar disorder (BD). Methods Electronic MEDLINE/PubMed/Cochrane-Library/Scopus/TripDatabase search until 06/30/2019 for studies comparing antioxidant or oxidative stress markers between BD and healthy controls (HCs). Standardized mean differences (SMD) and 95% confidence intervals (CIs) were calculated for >= 3 studies. Results Forty-four studies (n = 3,767: BD = 1,979; HCs = 1,788) reported on oxidative stress markers malondialdehyde (MDA), thiobarbituric acid reactive substances (TBARS), and total nitrites; antioxidants glutathione (GSH), uric acid, and zinc; or antioxidantenhancing enzymes superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX), and GSH-transferase (GST). Compared with HCs, BD was associated with higher GST (P = .01), CAT (P = .02), nitrites (P < .0001), TBARS (P < .0001), MDA (P = .01), uric acid (P < .0001), and lower GSH (P = .006), without differences in SOD, GPX, and zinc. Compared to HCs, levels were higher in BD-mania for TBARS (P < .0001) and uric acid (P < .0001); in BD-depression for TBARS (P = .02); and BD-euthymia for uric acid (P = .03). Uric acid levels were higher in BD-mania vs BD-depression (P = .002), but not vs BD euthymia. TBARS did not differ between BD-mania and BD-depression. Medication-free BD-mania patients had higher SOD (P = .02) and lower GPX (P < .0001) than HCs. After treatment, BD did not differ from HCs regarding SOD and GPX. Conclusions Beyond a single biomarker of oxidative stress, the combination of several parameters appears to be more informative for BD in general and taking into account illness polarity. BD is associated with an imbalance in oxidative stress with some phase-specificity for uric acid and TBARS and possible treatment benefits for SOD and GPX. Future studies should take into account confounding factors that can modify oxidative stress status and simultaneously measure oxidative stress markers and antioxidants including different blood sources.
C1 [Jimenez-Fernandez, Sara; Gurpegui, Manuel; Gutierrez-Rojas, Luis] Univ Granada, Inst Neurosci, CTS Res Grp 549, Granada, Spain.
   [Jimenez-Fernandez, Sara] Jaen Med Ctr, Child & Adolescent Mental Hlth Unit, Jaen, Spain.
   [Gurpegui, Manuel; Gutierrez-Rojas, Luis; Carretero, Maria D.] Univ Granada, Dept Psychiat, Granada, Spain.
   [Garrote-Rojas, D. aniel] Univ Granada, Dept Pedag, Granada, Spain.
   [Gutierrez-Rojas, Luis] San Cecilio Univ Hosp, Psychiat Serv, Granada, Spain.
   [Correll, Christoph U.] Zucker Hillside Hosp, Dept Psychiat Res, Northwell Hlth, Glen Oaks, NY USA.
   [Correll, Christoph U.] Donald & Barbara Zucker Sch Med Hofstra Northwell, Dept Psychiat & Mol Med, Hempstead, NY USA.
   [Correll, Christoph U.] Feinstein Inst Med Res, Ctr Psychiat Neurosci, Manhasset, NY USA.
   [Correll, Christoph U.] Charite, Dept Child & Adolescent Psychiat, Berlin, Germany.
C3 University of Granada; University of Granada; University of Granada;
   Hospital Universitario San Cecilio; Northwell Health; Northwell Health;
   Northwell Health; Berlin Institute of Health; Free University of Berlin;
   Humboldt University of Berlin; Charite Universitatsmedizin Berlin
RP Correll, CU (corresponding author), Zucker Hillside Hosp, Div Psychiat Res, Glen Oaks, NY 11004 USA.
EM ccorrell@nothwell.edu
RI Garrote Rojas, Daniel/AAB-5527-2022; Jiménez-Fernández,
   Sara/MBV-1302-2025; Gurpegui, Manuel/JDD-0226-2023; Rojas,
   Luis/AAI-1110-2021; Correll, Christoph/D-3530-2011
OI GARROTE ROJAS, DANIEL/0000-0002-5970-3646; Jimenez Fernandez,
   Sara/0000-0003-1515-2413; Gurpegui, Manuel/0000-0002-1262-1627; Correll,
   Christoph U/0000-0002-7254-5646; Gutierrez-Rojas,
   Luis/0000-0003-0082-2189
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NR 71
TC 69
Z9 71
U1 6
U2 18
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1398-5647
EI 1399-5618
J9 BIPOLAR DISORD
JI Bipolar Disord.
PD MAR
PY 2021
VL 23
IS 2
BP 117
EP 129
DI 10.1111/bdi.12980
EA SEP 2020
PG 13
WC Clinical Neurology; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA QW5VS
UT WOS:000568816200001
PM 32780547
OA hybrid
DA 2025-06-11
ER

PT J
AU Yaffe, K
   Hoang, TD
   Byers, AL
   Barnes, DE
   Friedl, KE
AF Yaffe, Kristine
   Hoang, Tina D.
   Byers, Amy L.
   Barnes, Deborah E.
   Friedl, Karl E.
TI Lifestyle and health-related risk factors and risk of cognitive aging
   among older veterans
SO ALZHEIMERS & DEMENTIA
LA English
DT Article
DE Veterans; Dementia; Cognitive aging; Lifestyle behaviors; Health-related
   risk factors
ID POSTTRAUMATIC-STRESS-DISORDER; OBSTRUCTIVE SLEEP-APNEA; CEREBRAL
   WHITE-MATTER; US ARMY SOLDIERS; ALZHEIMERS-DISEASE; PHYSICAL-ACTIVITY;
   METABOLIC SYNDROME; BLOOD-PRESSURE; SOCIAL NETWORK; MENTAL-HEALTH
AB Lifestyle and health-related factors are critical components of the risk for cognitive aging among veterans. Because dementia has a prolonged prodromal phase, understanding effects across the life course could help focus the timing and duration of prevention targets. This perspective may be especially relevant for veterans and health behaviors. Military service may promote development and maintenance of healthy lifestyle behaviors, but the period directly after active duty has ended could be an important transition stage and opportunity to address some important risk factors. Targeting multiple pathways in one intervention may maximize efficiency and benefits for veterans. A recent review of modifiable risk factors for Alzheimer's disease estimated that a 25% reduction of a combination of seven modifiable risk factors including diabetes, hypertension, obesity, depression, physical inactivity, smoking, and education/cognitive inactivity could prevent up to 3 million cases worldwide and 492,000 cases in the United States. Lifestyle interventions to address cardiovascular health in veterans may serve as useful models with both physical and cognitive activity components, dietary intervention, and vascular risk factor management. Although the evidence is accumulating for lifestyle and health-related risk factors as well as military risk factors, more studies are needed to characterize these factors in veterans and to examine the potential interactions between them. Published by Elsevier Inc. on behalf of The Alzheimer's Association.
C1 [Yaffe, Kristine; Byers, Amy L.; Barnes, Deborah E.] Univ Calif San Francisco, Dept Psychiat, San Francisco, CA 94143 USA.
   [Yaffe, Kristine; Friedl, Karl E.] Univ Calif San Francisco, Dept Neurol, San Francisco, CA USA.
   [Yaffe, Kristine] Univ Calif San Francisco, Dept Epidemiol, San Francisco, CA 94143 USA.
   [Yaffe, Kristine] San Francisco VA Med Ctr, San Francisco, CA USA.
   [Hoang, Tina D.] Northern Calif Inst Res & Educ, San Francisco, CA USA.
C3 University of California System; University of California San Francisco;
   University of California System; University of California San Francisco;
   University of California System; University of California San Francisco;
   US Department of Veterans Affairs; Veterans Health Administration (VHA);
   San Francisco VA Medical Center; Northern California Institute for
   Research & Education
RP Yaffe, K (corresponding author), Univ Calif San Francisco, Dept Psychiat, San Francisco, CA 94143 USA.
EM kristine.yaffe@ucsf.edu
RI Yaffe, Kristine/LLL-8209-2024; Friedl, Karl/M-1803-2019
FU United States Army Medical Research and Materiel Command
FX Publication of this article was supported by the United States Army
   Medical Research and Materiel Command.
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NR 160
TC 53
Z9 63
U1 1
U2 30
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1552-5260
EI 1552-5279
J9 ALZHEIMERS DEMENT
JI Alzheimers. Dement.
PD JUN
PY 2014
VL 10
IS 3
SU 1
BP S111
EP S121
DI 10.1016/j.jalz.2014.04.010
PG 11
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology
GA CP8GM
UT WOS:000360130700007
PM 24924664
OA hybrid
DA 2025-06-11
ER

PT J
AU Byrne, CD
   Armandi, A
   Pellegrinelli, V
   Vidal-Puig, A
   Bugianesi, E
AF Byrne, Christopher D.
   Armandi, Angelo
   Pellegrinelli, Vanessa
   Vidal-Puig, Antonio
   Bugianesi, Elisabetta
TI Μetabolic dysfunction-associated steatotic liver disease: a condition of
   heterogeneous metabolic risk factors, mechanisms and comorbidities
   requiring holistic treatment
SO NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
LA English
DT Review
ID FATTY LIVER; INSULIN-RESISTANCE; CARDIOVASCULAR-DISEASE;
   ALCOHOL-CONSUMPTION; HEPATIC STEATOSIS; THYROID-HORMONES;
   CONTROLLED-TRIAL; S6 KINASE; STEATOHEPATITIS; CHOLESTEROL
AB Mu etabolic dysfunction-associated steatotic liver disease (MASLD) comprises a heterogeneous condition in the presence of steatotic liver. There can be a hierarchy of metabolic risk factors contributing to the severity of metabolic dysfunction and, thereby, the associated risk of both liver and extrahepatic outcomes, but the precise ranking and combination of metabolic syndrome (MetS) traits that convey the highest risk of major adverse liver outcomes and extrahepatic disease complications remains uncertain. Insulin resistance, low-grade inflammation, atherogenic dyslipidaemia and hypertension are key to the mechanisms of liver and extrahepatic complications. The liver is pivotal in MetS progression as it regulates lipoprotein metabolism and secretes substances that affect insulin sensitivity and inflammation. MASLD affects the kidneys, heart and the vascular system, contributing to hypertension and oxidative stress. To address the global health burden of MASLD, intensified by obesity and type 2 diabetes mellitus epidemics, a holistic, multidisciplinary approach is essential. This approach should focus on both liver disease management and cardiometabolic risk factors. This Review examines the link between metabolic dysfunction and liver dysfunction and extrahepatic disease outcomes, the diverse mechanisms in MASLD due to metabolic dysfunction, and a comprehensive, personalized management model for patients with MASLD.
C1 [Byrne, Christopher D.] Univ Hosp Southampton, Southampton Biomed Res Ctr, Natl Inst Hlth & Care Res, Southampton, England.
   [Byrne, Christopher D.] Univ Southampton, Southampton, England.
   [Armandi, Angelo; Bugianesi, Elisabetta] Univ Turin, Dept Med Sci, Div Gastroenterol & Hepatol, Turin, Italy.
   [Pellegrinelli, Vanessa; Vidal-Puig, Antonio] Univ Cambridge, Inst Metab Sci, MRC MDU Unit, Cambridge, England.
   [Pellegrinelli, Vanessa; Vidal-Puig, Antonio] Ctr Invest Principe Felipe, Valencia, Spain.
C3 University of Southampton; University of Turin; University of Cambridge;
   Prince Felipe Research Center
RP Bugianesi, E (corresponding author), Univ Turin, Dept Med Sci, Div Gastroenterol & Hepatol, Turin, Italy.
EM elisabetta.bugianesi@unito.it
RI Armandi, Angelo/AAU-6395-2020; Bugianesi, Elisabetta/K-8008-2016
OI Byrne, Christopher D/0000-0001-6322-7753
FU Southampton National Institute for Health and Care Research, Biomedical
   Research Centre; Italian Ministry for Education, University and Research
   (MIUR) under the programme 'Dipartimenti di Eccellenza [D15D18000410001,
   2022L273C9]; IMI Litmus, MRC Programme grant; BHF programme; Caixa
   Foundation; Spanish Government ATRAE Programme;  [NIHR 203319]; 
   [2018-2022];  [MC_UU_00014/2];  [RG/18/7/33636]
FX C.D.B. is funded in part by the Southampton National Institute for
   Health and Care Research, Biomedical Research Centre (NIHR 203319). E.B.
   is funded by the Italian Ministry for Education, University and Research
   (MIUR) under the programme 'Dipartimenti di Eccellenza 2018-2022'
   Project code D15D18000410001 and Precision medicine to stratify disease
   severity and outcomes of patients with nonalcoholic fatty liver disease
   by using artificial intelligence - Next Generation EU - grant number
   2022L273C9. E.B. and A.A. are funded by PNRR 'D3 4 Health - Digital
   Driven Diagnostics, prognostics and therapeutics for sustainable Health
   care', Piano Nazionale per gli investimenti Complementari (PNC) al Piano
   Nazionale di Ripresa e Resilienza - Decreto di Concessione n. 1986 del 9
   dicembre 2022, Codice progetto MUR: PNC0000001 - CUP ENTE:
   B53C22006110001. A.V.-P. and E.B. are funded by IMI Litmus, MRC
   Programme grant MC_UU_00014/2, BHF programme grant RG/18/7/33636. Caixa
   Foundation and Spanish Government ATRAE Programme.
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NR 157
TC 2
Z9 2
U1 9
U2 9
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 1759-5045
EI 1759-5053
J9 NAT REV GASTRO HEPAT
JI Nat. Rev. Gastroenterol. Hepatol.
PD MAY
PY 2025
VL 22
IS 5
BP 314
EP 328
DI 10.1038/s41575-025-01045-z
EA FEB 2025
PG 15
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 2CO5G
UT WOS:001423023600001
PM 39962331
DA 2025-06-11
ER

PT J
AU Koite, NLN
   Sanogo, NI
   Lépine, O
   Bard, JM
   Ouguerram, K
AF Koite, N'Deye Lallah Nina
   Sanogo, N'gouro Issa
   Lepine, Olivier
   Bard, Jean-Marie
   Ouguerram, Khadija
TI Antioxidant Efficacy of a Spirulina Liquid Extract on Oxidative
   Stress Status and Metabolic Disturbances in Subjects with Metabolic
   Syndrome
SO MARINE DRUGS
LA English
DT Article
DE metabolic syndrome; dyslipidemia; oxLDL/LDL cholesterol; isoprostanes;
   Arthrospira liquid extract
ID C-PHYCOCYANIN; SAMPLE-SIZE; SUPPLEMENTATION; PLATENSIS; INFLAMMATION;
   METAANALYSIS; BILIPROTEIN; MICROALGAE; DISEASE; IMPACT
AB Lipid peroxidation is associated with the development of some pathologies, such as cardiovascular diseases. Reduction in oxidative stress by antioxidants, such as Arthrospira (formely Spirulina), helps improving this redox imbalance. The aim of the study was to evaluate the effect of the Arthrospira liquid extract "Spirulysat (R)" on oxidative markers-in particular, oxidized LDL (oxLDL)/total LDL cholesterol-and isoprostanes and to investigate its impact on lipid and glucose metabolism in the metabolic syndrome subject. A controlled, randomised, double-blind design was conducted in 40 subjects aged 18 to 65 years with metabolic syndrome after a daily intake of Spirulysat (R) or placebo for twelve weeks. Blood and urinary samples were collected at three visits (V1, V2, V3) in the two groups for parameters determination. Although the Spirulysat (R) group showed a decrease at all visits of the oxLDL/total cholesterol ratio, there was no significant difference compared to the placebo (p = 0.36). The urinary isoprostanes concentration in the Spirulysat (R) group was reduced (p = 0.014) at V3. Plasma triglycerides decreased at V3 (p = 0.003) and HDL-cholesterol increased (p = 0.031) at all visits with Spirulysat (R). In conclusion, Spirulysat (R) did not change the oxidized LDL (oxLDL)/LDL ratio but decreased the urinary isoprostanes, plasma triglycerides and increased HDL cholesterol, suggesting a beneficial effect on metabolic syndrome.
C1 [Koite, N'Deye Lallah Nina] Univ Sci Tech & Technol, Fac Pharm, Dept Rech Sante Publ, J287 PM5, Bamako, Mali.
   [Sanogo, N'gouro Issa] Inst Jerome Lejeune, F-75870 Paris, France.
   [Lepine, Olivier] AlgoSource Technol, F-44600 St Nazaire, France.
   [Bard, Jean-Marie] Nantes Univ, IUML Inst Univ Mer & Littoral, ISOMer UE 2160, CNRS, F-44035 Nantes, France.
   [Bard, Jean-Marie] Inst Cancerol Ouest, F-44805 St Herblain, France.
   [Bard, Jean-Marie] Ctr Rech Nutr Humaine Quest CRNH O, F-44093 Nantes, France.
   [Ouguerram, Khadija] Nantes Univ, Ctr Rech Nutr Humaine Quest CRNH O, Inst Malad Appareil Digestif IMAD, INRAE,Unite Mixte Rech,Physiopathol Adaptat Nutr, F-44093 Nantes, France.
C3 University of Science & Technology of Bamako; Centre National de la
   Recherche Scientifique (CNRS); Nantes Universite; UNICANCER; Institut de
   Cancerologie de l'Ouest (ICO); Nantes Universite; CHU de Nantes; INRAE
RP Ouguerram, K (corresponding author), Nantes Univ, Ctr Rech Nutr Humaine Quest CRNH O, Inst Malad Appareil Digestif IMAD, INRAE,Unite Mixte Rech,Physiopathol Adaptat Nutr, F-44093 Nantes, France.
EM ndeyevictor@gmail.com; ngsanogo@gmail.com;
   olivier.lepine@algosource.com; jean-marie.bard@univ-nantes.fr;
   khadija.ouguerram@univ-nantes.fr
RI Bard, Jean-Marie/AFT-1583-2022
OI Bard, Jean-Marie/0000-0002-9123-8123; Lepine,
   Olivier/0000-0001-6914-9186
FU AlgoSource
FX This work was supported by AlgoSource.
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NR 57
TC 14
Z9 14
U1 4
U2 9
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1660-3397
J9 MAR DRUGS
JI Mar. Drugs
PD JUL
PY 2022
VL 20
IS 7
AR 441
DI 10.3390/md20070441
PG 13
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 3H3FF
UT WOS:000831923500001
PM 35877734
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Morange, PE
   Alessi, MC
AF Morange, Pierre-Emmanuel
   Alessi, Marie-Christine
TI Thrombosis in central obesity and metabolic syndrome: Mechanisms and
   epidemiology
SO THROMBOSIS AND HAEMOSTASIS
LA English
DT Article
DE Haemostasis; metabolic syndrome; visceral obesity; thrombosis
ID PLASMINOGEN-ACTIVATOR INHIBITOR-1; MEAN PLATELET VOLUME; SOLUBLE CD40
   LIGAND; NUTRITIONALLY INDUCED OBESITY; ADIPOSE-TISSUE DEVELOPMENT;
   CORONARY-ARTERY-DISEASE; LOW-DENSITY-LIPOPROTEIN; FACTOR
   GENE-EXPRESSION; HUMAN SKELETAL-MUSCLE; DEEP-VEIN THROMBOSIS
AB Central obesity is a key feature of the metabolic syndrome (metS), a multiplex risk factor for subsequent development of type 2 diabetes and cardiovascular disease. Many metabolic alterations closely related to this condition exert effects on platelets and vascular cells. A procoagulant and hypofibrinolytic state has been identified, mainly underlain by inflammation, oxidative stress, dyslipidaemia, and ectopic fat that accompany central obesity. In support of these data, central obesity independently predisposes not only to atherothrombosis but also to venous thrombosis.
C1 [Morange, Pierre-Emmanuel; Alessi, Marie-Christine] Univ Mediterranee, Fac Med, Inserm UMR 1062, Lab Hematol, F-13385 Marseille, France.
C3 Aix-Marseille Universite; Institut National de la Sante et de la
   Recherche Medicale (Inserm)
RP Alessi, MC (corresponding author), Univ Mediterranee, Fac Med, Inserm UMR 1062, Lab Hematol, 27 Bd Jean Moulin, F-13385 Marseille, France.
EM marie-christine.alessi@univ-amu.fr
RI Morange, Pierre/T-9070-2019; ALESSI, Marie-christine/AAK-3582-2020
OI Morange, Pierre/0000-0002-9065-722X; ALESSI,
   Marie-christine/0000-0003-3927-5792
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NR 163
TC 101
Z9 108
U1 1
U2 15
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0340-6245
EI 2567-689X
J9 THROMB HAEMOSTASIS
JI Thromb. Haemost.
PD OCT
PY 2013
VL 110
IS 4
BP 669
EP 680
DI 10.1160/TH13-01-0075
PG 12
WC Hematology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Hematology; Cardiovascular System & Cardiology
GA 241CS
UT WOS:000326144600009
PM 23765199
DA 2025-06-11
ER

PT J
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   Hirschberg, AL
   Kiesel, L
   Lopes, P
   Pines, A
   van Trotsenburg, M
   Lambrinoudaki, I
   Rees, M
AF Cano, Antonio
   Marshall, Skye
   Zolfaroli, Irene
   Bitzer, Johannes
   Ceausu, Iuliana
   Chedraui, Peter
   Durmusoglu, Fatih
   Erkkola, Risto
   Goulis, Dimitrios G.
   Hirschberg, Angelica Linden
   Kiesel, Ludwig
   Lopes, Patrice
   Pines, Amos
   van Trotsenburg, Mick
   Lambrinoudaki, Irene
   Rees, Margaret
TI The Mediterranean diet and menopausal health: An EMAS position statement
SO MATURITAS
LA English
DT Article
DE Mediterranean diet; Health; Non-communicable disease; Menopause; Women's
   health
ID HIGH-CARDIOVASCULAR-RISK; BREAST-CANCER RISK; WOMENS HEALTH; LIFE-STYLE;
   MUSCULOSKELETAL HEALTH; MYOCARDIAL-INFARCTION; POSTMENOPAUSAL WOMEN;
   WAIST CIRCUMFERENCE; VASOMOTOR SYMPTOMS; METABOLIC SYNDROME
AB Introduction: Globally, 985 million women are aged 50 and over, leading to increasing concerns about chronic conditions such as cardiovascular disease, osteoporosis, dementia, and cognitive decline, which can adversely affect quality of life and independent living.
   Aim: To evaluate the evidence from observational studies and randomized trials on the effects of the Mediterranean diet on short- and long-term menopausal health: estrogen deficiency symptoms, cardiovascular disease, osteoporosis, cognitive and mental health, breast cancer, and all-cause mortality.
   Materials and methods: Literature review and consensus of expert opinion.
   Summary recommendations: The Mediterranean diet is a non-restrictive dietary pattern common in the olive-growing areas of the Mediterranean basin. It may improve vasomotor symptoms, cardiovascular risk factors such as blood pressure, cholesterol and blood glucose levels, as well as mood and symptoms of depression. Long-term adherence may: improve cardiovascular risk and events, and death; improve bone mineral density; prevent cognitive decline; and reduce the risk of breast cancer and all-cause mortality.
C1 [Cano, Antonio; Zolfaroli, Irene] Univ Valencia, Dept Pediat Obstet & Gynecol, Valencia, Spain.
   [Cano, Antonio; Zolfaroli, Irene] INCLIVA, Valencia, Spain.
   [Marshall, Skye] Nutr Res Australia, Callaghan, NSW, Australia.
   [Marshall, Skye] Bond Univ, Nutr & Dietet Res Grp, Fac Hlth Sci & Med, Robina, Qld, Australia.
   [Bitzer, Johannes] Univ Hosp, Dept Obstet & Gynecol, Basel, Switzerland.
   [Ceausu, Iuliana] Carol Davila Univ Med & Pharm, Dr I Cantacuzino Hosp, Dept Obstet & Gynecol 1, Bucharest, Romania.
   [Chedraui, Peter] Univ Catolica Santiago Guayaquil, Fac Ciencias Med, Inst Invest & Innovac Salud Integral ISAIN, Guayaquil, Ecuador.
   [Durmusoglu, Fatih] Istanbul Medipol Int Sch Med, Istanbul, Turkey.
   [Erkkola, Risto] Univ Cent Hosp Turku, Dept Obstet & Gynecol, Turku, Finland.
   [Goulis, Dimitrios G.] Aristotle Univ Thessaloniki, Med Sch, Dept Obstet & Gynecol 1, Unit Reprod Endocrinol, Thessaloniki, Greece.
   [Hirschberg, Angelica Linden] Karolinska Inst, Dept Womens & Childrens Hlth, Stockholm, Sweden.
   [Hirschberg, Angelica Linden] Karolinska Univ Hosp, Dept Gynecol & Reprod Med, Stockholm, Sweden.
   [Kiesel, Ludwig] Univ Munster, Dept Gynecol & Obstet, Munster, Germany.
   [Lopes, Patrice] France Polyclin Atlant St Herblain, F-44819 St Herblain, France.
   [Lopes, Patrice] Univ Nantes, F-44093 Nantes, France.
   [Pines, Amos] Tel Aviv Univ, Sackler Fac Med, Tel Aviv, Israel.
   [van Trotsenburg, Mick] Univ Hosp St Poelten Lilienfeld, Dept Obstet & Gynecol, St Polten, Austria.
   [Lambrinoudaki, Irene] Natl & Kapodistrian Univ Athens, Aretaieio Hosp, Med Sch, Dept Obstet & Gynecol 2, Athens, Greece.
   [Rees, Margaret] John Radcliffe Hosp, Womens Ctr, Oxford OX3 9DU, England.
C3 University of Valencia; Bond University; Carol Davila University of
   Medicine & Pharmacy; University of Turku; Aristotle University of
   Thessaloniki; Karolinska Institutet; Karolinska Institutet; Karolinska
   University Hospital; University of Munster; Nantes Universite; Tel Aviv
   University; Sackler Faculty of Medicine; National & Kapodistrian
   University of Athens; University of Oxford
RP Cano, A (corresponding author), Univ Valencia, Dept Pediat Obstet & Gynecol, Valencia, Spain.; Cano, A (corresponding author), INCLIVA, Valencia, Spain.
EM Antonio.Cano@uv.es
RI Hirschberg, Angelica/AAE-6980-2022; Goulis, Dimitrios/AAG-4589-2020;
   Kiesel, Ludwig/ABC-5333-2020; Blümel, Juan Enrique/JUV-6950-2023;
   Marshall, Skye/D-2435-2016
OI Hirschberg, Angelica Linden/0000-0001-6481-6277; Marshall,
   Skye/0000-0001-8953-5068; Lambrinoudaki, Irene/0000-0003-1488-2668
FU Sistema de Investigacion y Desarrollo (SINDE) of the Universidad
   Catolica de Santiago de Guayaquil, Guayaquil, Ecuador
   [SIU-318-853-2014]; Vice-Rectorado de Investigacion & Postgrado (VRIP)
   of the Universidad Catolica de Santiago de Guayaquil, Guayaquil, Ecuador
   [SIU-318-853-2014]
FX Peter Chedraui is supported by the Sistema de Investigacion y Desarrollo
   (SINDE) and the Vice-Rectorado de Investigacion & Postgrado (VRIP) of
   the Universidad Catolica de Santiago de Guayaquil, Guayaquil, Ecuador,
   through grant No. SIU-318-853-2014 (The Omega II, Women's Health
   Project). Neither SINDE nor VRIP have had involvement in the writing of
   this position statement.
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NR 110
TC 46
Z9 49
U1 4
U2 19
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0378-5122
EI 1873-4111
J9 MATURITAS
JI Maturitas
PD SEP
PY 2020
VL 139
BP 90
EP 97
DI 10.1016/j.maturitas.2020.07.001
PG 8
WC Geriatrics & Gerontology; Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology; Obstetrics & Gynecology
GA MW0UU
UT WOS:000556763600012
PM 32682573
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Sekar, S
   Shafie, SR
   Prasadam, I
   Crawford, R
   Panchal, SK
   Brown, L
   Xiao, Y
AF Sekar, Sunderajhan
   Shafie, Siti Raihanah
   Prasadam, Indira
   Crawford, Ross
   Panchal, Sunil K.
   Brown, Lindsay
   Xiao, Yin
TI Saturated fatty acids induce development of both metabolic syndrome and
   osteoarthritis in rats
SO SCIENTIFIC REPORTS
LA English
DT Article
ID ARTICULAR-CARTILAGE CHONDROCYTES; ADIPOSE-TISSUE; OBESITY; PATHOGENESIS;
   INFLAMMATION; STRESS; DISORDERS; HEALTHY; PATHWAY; WEIGHT
AB The predominant saturated fatty acids (SFA) in human diets are lauric acid (LA, C12:0), myristic acid (MA, C14:0), palmitic acid (PA, C16:0) and stearic acid (SA, C18:0). The aim of this study was to investigate whether diets containing individual SFA together with excess simple carbohydrates induce osteoarthritis (OA)-like changes in knee joints and signs of metabolic syndrome in rats. Rats were given either a corn starch diet or a diet composed of simple carbohydrates together with 20% LA, MA, PA, SA or beef tallow for 16 weeks. Rats fed beef tallow, SA, MA or PA diets developed signs of metabolic syndrome, and also exhibited cartilage degradation and subchondral bone changes similar to OA. In contrast, replacement of beef tallow with LA decreased signs of metabolic syndrome together with decreased cartilage degradation. Furthermore, PA and SA but not LA increased release of matrix sulphated proteoglycans in cultures of bovine cartilage explants or human chondrocytes. In conclusion, we have shown that longer-chain dietary SFA in rats induce both metabolic syndrome and OA-like knee changes. Thus, diets containing SFA are strongly relevant to the development or prevention of both OA and metabolic syndrome.
C1 [Sekar, Sunderajhan; Prasadam, Indira; Xiao, Yin] Queensland Univ Technol, Inst Hlth & Biomed Innovat, Sch Chem, Phys,Mech Engn, Brisbane, Qld, Australia.
   [Shafie, Siti Raihanah; Panchal, Sunil K.; Brown, Lindsay] Univ Southern Queensland, Inst Agr & Environm, Brisbane, Qld, Australia.
   [Shafie, Siti Raihanah; Panchal, Sunil K.; Brown, Lindsay] Univ Southern Queensland, Sch Hlth & Wellbeing, Brisbane, Qld, Australia.
   [Crawford, Ross] Prince Charles Hosp, Dept Orthopaed, Brisbane, Qld, Australia.
C3 Queensland University of Technology (QUT); University of Southern
   Queensland; University of Southern Queensland; Prince Charles Hospital
RP Xiao, Y (corresponding author), Queensland Univ Technol, Inst Hlth & Biomed Innovat, Sch Chem, Phys,Mech Engn, Brisbane, Qld, Australia.
EM yin.xiao@qut.edu.au
RI Shafie, Siti/AAJ-3033-2020; Xiao, Yin/AAM-4033-2020; Shafie,
   Siti/G-1959-2017; Sekar, Sunderajhan/U-5651-2017
OI Panchal, Sunil K/0000-0001-5464-3376; Prasadam,
   Indira/0000-0001-5057-2427; Crawford, Ross/0000-0001-6079-1316; Xiao,
   Yin/0000-0003-1785-3491; Shafie, Siti/0000-0003-2983-7536; Sekar,
   Sunderajhan/0000-0003-1566-9316
FU Prince Charles Hospital Foundation; USQ Strategic Research Fund
FX Authors would like to thank Lynn Hamilton (University of Southern
   Queensland) for care of research animals and Jason Brightwell (The
   Prince Charles Hospital) for echocardiography. Authors would also like
   to thank Mrs Wei Shi (Queensland University of Technology) for her
   assistance in the histology work. Authors acknowledge the funding
   support from The Prince Charles Hospital Foundation and the USQ
   Strategic Research Fund.
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NR 43
TC 87
Z9 92
U1 1
U2 12
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD APR 18
PY 2017
VL 7
AR 46457
DI 10.1038/srep46457
PG 11
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA ES2MY
UT WOS:000399363800001
PM 28418007
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Puig, JG
   Martínez, MA
AF Puig, Juan Garcia
   Martinez, Maria Angeles
TI Hyperuricemia, gout and the metabolic syndrome
SO CURRENT OPINION IN RHEUMATOLOGY
LA English
DT Review
DE cardiovascular disease; gout; hyperuricemia; metabolic syndrome
ID SERUM URIC-ACID; AMERICAN-DIABETES-ASSOCIATION; CORONARY-HEART-DISEASE;
   3RD NATIONAL-HEALTH; CARDIOVASCULAR-DISEASE; PROVISIONAL REPORT;
   OXIDATIVE STRESS; RISK; PREVALENCE; DEFINITION
AB Purpose of review
   The metabolic syndrome is defined by the clustering of a number of cardiovascular risk factors and entails an increased risk for cardiovascular disease and mortality from both cardiovascular disease and all causes. In the present paper, we review the most recent evidence on the association between hyperuricemia, metabolic syndrome, and cardiovascular disease.
   Recent findings
   Serum urate is frequently elevated in patients with the metabolic syndrome and increases with the number of components of this condition. Hyperuricemia has been related to decreased renal uric acid excretion, which may be mediated by enhanced proximal tubular sodium reabsorption and hyperinsulinemia. Recent epidemiologic studies have shed some light on the prognosis of hyperuricemia. While hyperuricemia appears to show a benign significance in low cardiovascular risk individuals, it clearly increases cardiovascular mortality in patients at high cardiovascular disease risk.
   Summary
   Clinicians should be aware of the presence of metabolic syndrome in patients with hyperuricemia or gout in order to control its components (high blood pressure, obesity, etc.) and hence reduce the risk for cardiovascular disease. Long-term, randomized interventional clinical trials are needed to test the hypothesis that urate-lowering therapy can reduce cardiovascular risk in these patients.
C1 [Puig, Juan Garcia; Martinez, Maria Angeles] La Paz Univ Hosp, Div Internal Med, Vasc Risk Unit, Madrid, Spain.
C3 Hospital Universitario La Paz
RP Puig, JG (corresponding author), Hosp Univ La Paz, Unidad Metab Vasc, Med Interna Serv, Edif Consultas Externas Planta SS,CX 12,, Madrid 28046, Spain.
EM jgarciapuig@terra.es
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TC 145
Z9 163
U1 3
U2 39
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1040-8711
EI 1531-6963
J9 CURR OPIN RHEUMATOL
JI Curr. Opin. Rheumatol.
PD MAR
PY 2008
VL 20
IS 2
BP 187
EP 191
DI 10.1097/BOR.0b013e3282f4b1ed
PG 5
WC Rheumatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Rheumatology
GA 266YW
UT WOS:000253475200011
PM 18349749
DA 2025-06-11
ER

PT J
AU Muller, CJF
   Malherbe, CJ
   Chellan, N
   Yagasaki, K
   Miura, Y
   Joubert, E
AF Muller, Christo J. F.
   Malherbe, Christiaan J.
   Chellan, Nireshni
   Yagasaki, Kazumi
   Miura, Yutaka
   Joubert, Elizabeth
TI Potential of rooibos, its major C-glucosyl flavonoids, and
   Z-2-(β-D-glucopyranosyloxy)-3-phenylpropenoic acid in prevention
   of metabolic syndrome
SO CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
LA English
DT Review
DE Dihydrochalcone; aspalathin; flavones; orientin; isoorientin; diabetes;
   obesity; bioavailability
ID ALPHA-GLUCOSIDASE INHIBITORS; TEA ASPALATHUS-LINEARIS;
   ANGIOTENSIN-CONVERTING ENZYME; INDUCED INSULIN-RESISTANCE;
   ANTI-ALZHEIMERS DISEASE; IN-VITRO; ANTIOXIDANT ACTIVITY; GREEN TEA;
   PHENOLIC-COMPOUNDS; HERBAL TEA
AB Risk factors of type 2 diabetes mellitus (T2D) and cardiovascular disease (CVD) cluster together and are termed the metabolic syndrome. Key factors driving the metabolic syndrome are inflammation, oxidative stress, insulin resistance (IR), and obesity. IR is defined as the impairment of insulin to achieve its physiological effects, resulting in glucose and lipid metabolic dysfunction in tissues such as muscle, fat, kidney, liver, and pancreatic beta-cells. The potential of rooibos extract and its major C-glucosyl flavonoids, in particular aspalathin, a C-glucoside dihydrochalcone, as well as the phenolic precursor, Z-2-(beta-D-glucopyranosyloxy)-3-phenylpropenoic acid, to prevent the metabolic syndrome, will be highlighted. The mechanisms whereby these phenolic compounds elicit positive effects on inflammation, cellular oxidative stress and transcription factors that regulate the expression of genes involved in glucose and lipid metabolism will be discussed in terms of their potential in ameliorating features of the metabolic syndrome and the development of serious metabolic disease. An overview of the phenolic composition of rooibos and the changes during processing will provide relevant background on this herbal tea, while a discussion of the bioavailability of the major rooibos C-glucosyl flavonoids will give insight into a key aspect of the bioefficacy of rooibos.
C1 [Muller, Christo J. F.; Chellan, Nireshni] South African Med Res Council, Biomed Res & Innovat Platform, Tygerberg, South Africa.
   [Malherbe, Christiaan J.; Joubert, Elizabeth] Agr Res Council, Infruitec Nietvoorbij, Postharvest & Wine Technol Div, Private Bag X5026, ZA-7599 Stellenbosch, South Africa.
   [Yagasaki, Kazumi; Miura, Yutaka] Tokyo Univ Agr & Technol, Inst Agr, Div Appl Biol Chem, Fuchu, Tokyo, Japan.
   [Yagasaki, Kazumi] Utsunomiya Univ, Ctr Biosci Res & Educ, Utsunomiya, Tochigi, Japan.
   [Joubert, Elizabeth] Stellenbosch Univ, Dept Food Sci, Private Bag X1, Stellenbosch, South Africa.
C3 South African Medical Research Council; Agricultural Research Council of
   South Africa; Tokyo University of Agriculture & Technology; Utsunomiya
   University; Stellenbosch University
RP Joubert, E (corresponding author), Agr Res Council, Infruitec Nietvoorbij, Postharvest & Wine Technol Div, Private Bag X5026, ZA-7599 Stellenbosch, South Africa.
EM joubertL@arc.agric.za
RI Miura, Yutaka/C-5457-2013; Yagasaki, Kazumi/AAG-8828-2020; Chellan,
   Nireshni/M-3037-2013
OI Joubert, Elizabeth/0000-0002-9717-9769; Chellan,
   Nireshni/0000-0001-9968-0998; Malherbe, Christiaan/0000-0001-8485-7877
FU National Research Foundation (NRF) of South Africa [75425, 85105,
   95520]; Japanese Society for the Promotion of Science; NRF
FX Funding for collaboration was provided by the National Research
   Foundation (NRF) of South Africa (grants 75425, 85105 and 95520 to E.
   Joubert.) and the Japanese Society for the Promotion of Science (grants
   to K. Yagasaki and Y. Miura). The NRF grant holder (EJ) acknowledges
   that opinions, findings, and conclusions or recommendations expressed in
   any publication generated by the NRF supported research are those of the
   authors, and that the NRF accepts no liability whatsoever in this
   regard. The funding bodies had no involvement in the study design,
   collection, analysis and interpretation of data, writing of the
   manuscript, or decision to publish the work.
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NR 172
TC 49
Z9 50
U1 2
U2 36
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1040-8398
EI 1549-7852
J9 CRIT REV FOOD SCI
JI Crit. Rev. Food Sci. Nutr.
PY 2018
VL 58
IS 2
BP 227
EP 246
DI 10.1080/10408398.2016.1157568
PG 20
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA FT8VH
UT WOS:000423430800005
PM 27305453
DA 2025-06-11
ER

PT J
AU Ndrepepa, G
   Kastrati, A
AF Ndrepepa, Gjin
   Kastrati, Adnan
TI Gamma-glutamyl transferase and cardiovascular disease
SO ANNALS OF TRANSLATIONAL MEDICINE
LA English
DT Review
DE Cardiovascular disease (CVD); gamma-glutamyl transferase (GGT);
   mortality; prognosis
ID FATTY LIVER-DISEASE; ALL-CAUSE MORTALITY; CARDIAC SYNDROME-X; PROGNOSTIC
   VALUE; ATRIAL-FIBRILLATION; ATHEROSCLEROTIC PLAQUES; METABOLIC SYNDROME;
   MYOCARDIAL-INFARCTION; GENERAL-POPULATION; HEPATIC STEATOSIS
AB Gamma-glutamyl transferase (GGT) is an enzyme located on the external surface of cellular membranes. GGT contributes in maintaining the physiological concentrations of cytoplasmic glutathione and cellular defense against oxidative stress via cleavage of extracellular glutathione and increased availability of amino acids for its intracellular synthesis. Increased GGT activity is a marker of antioxidant inadequacy and increased oxidative stress. Ample evidence suggests that elevated GGT activity is associated with increased risk of cardiovascular disease (CVD) such as coronary heart disease (CHD), stroke, arterial hypertension, heart failure, cardiac arrhythmias and all-cause and CVD-related mortality. The evidence is weaker for an association between elevated GGT activity and acute ischemic events and myocardial infarction. The risk for CVD or CVD-related mortality mediated by GGT may be explained by the close correlation of GGT with conventional CVD risk factors and various comorbidities, particularly non-alcoholic fatty liver disease, alcohol consumption, oxidative stress, metabolic syndrome, insulin resistance and systemic inflammation. The finding of GGT activity in atherosclerotic plaques and correlation of intra-plaque GGT activity with histological indexes of plaque instability may suggest a participation of GGT in the pathophysiology of CVD, particularly atherosclerosis. However, whether GGT has a direct role in the pathophysiology of CVD or it is an epiphenomenon of coexisting CVD risk factors or comorbidities remains unknown and Hill's criteria of causality relationship between GGT and CVD are not fulfilled. The exploration whether GGT provides prognostic information on top of the information provided by known cardiovascular risk factors regarding the CVD or CVD-related outcome and exploration of molecular mechanisms of GGT involvement in the pathophysiology of CVD and eventual use of interventions to reduce circulating GGT activity remain a duty of future studies.
C1 [Ndrepepa, Gjin; Kastrati, Adnan] Tech Univ Munich, Deutsch Herzzentrum Munchen, Dept Adult Cardiol, Munich, Germany.
   [Kastrati, Adnan] DZHK German Ctr Cardiovasc Research, Partner Site Munich Heart Alliance, Munich, Germany.
C3 German Heart Centre Munich; Technical University of Munich; Munich Heart
   Alliance; German Centre for Cardiovascular Research
RP Ndrepepa, G (corresponding author), Deutsch Herzzentrum Munich, Lazarettstr 36, D-80636 Munich, Germany.
EM ndrepepa@dhm.mhn.de
RI , Kastrati/Y-2389-2019
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NR 95
TC 95
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PU AME PUBLISHING COMPANY
PI SHATIN
PA FLAT-RM C 16F, KINGS WING PLAZA 1, NO 3 KWAN ST, SHATIN, HONG KONG
   00000, PEOPLES R CHINA
SN 2305-5839
EI 2305-5847
J9 ANN TRANSL MED
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PD DEC
PY 2016
VL 4
IS 24
AR 481
DI 10.21037/atm.2016.12.27
PG 14
WC Oncology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Research & Experimental Medicine
GA EI7DE
UT WOS:000392656900003
PM 28149843
OA Green Published
DA 2025-06-11
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SO AGRO FOOD INDUSTRY HI-TECH
LA English
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C1 Cognis Deutschland GmbH & Co KG, Nutr & Hlth, D-40789 Monheim, Germany.
C3 BASF
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J9 AGRO FOOD IND HI TEC
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PD SEP-OCT
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IS 5
BP XXVIII
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PG 3
WC Biotechnology & Applied Microbiology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Biotechnology & Applied Microbiology; Food Science & Technology
GA 116EU
UT WOS:000242786100017
DA 2025-06-11
ER

PT J
AU Liang, YZ
   Liu, Y
   Tan, Q
   Zhou, KY
   Wu, YR
   Yu, L
AF Liang, Yongzhou
   Liu, Ying
   Tan, Qin
   Zhou, Kaiyu
   Wu, Yurong
   Yu, Li
TI Systemic immune-inflammation mediates the association between Klotho
   protein and metabolic syndrome: findings from a large-scale
   population-based study
SO LIPIDS IN HEALTH AND DISEASE
LA English
DT Article
DE Klotho; Metabolic syndrome; Inflammation; Biomarkers; National Health
   and Nutrition Examination Survey
ID SOLUBLE KLOTHO; GENE; STRESS; HEALTH
AB BackgroundThis study utilized large-scale population data from the National Health and Nutrition Examination Survey (NHANES) to elucidate the relationship between the Klotho protein and metabolic syndrome along with its components. We further investigated the possible mediating effect of inflammation on these relationships. Our objective was to identify biomarkers for risk stratification and potential therapeutic targets for metabolic syndrome.MethodsThis study enrolled 13,119 participants aged 40-79 years, spanning five NHANES cycles from 2007 to 2016, with complete information on metabolic syndrome and the Klotho protein. The definition of metabolic syndrome followed the criteria of the National Cholesterol Education Program-Adult Treatment Panel III. Survey-weighted logistic regression and subgroup analysis were used to explore the associations between serum Klotho protein levels and metabolic syndrome, along with its components. Mediation analysis was performed to investigate the mediating effects of inflammation-related markers, including white blood cells, neutrophils, lymphocytes, monocytes, the neutrophil-to-lymphocyte ratio (NLR), the platelet-to-lymphocyte ratio (PLR), the systemic immune-inflammation index (SII) and the monocyte-to-HDL ratio (MHR), with the aim of elucidating how the Klotho protein influences the onset and progression of metabolic syndrome.ResultsThe study participants had an average age of 56.06 years (95% CI: 55.76-56.37), with a Klotho protein concentration of 798.10 pg/ml (95% CI: 656.50-980.50) and a 43.77% prevalence of metabolic syndrome (n = 5742). In the crude model, Klotho was negatively correlated with metabolic syndrome and its components, including central obesity, hypertension, and hypertriglyceridemia. After adjusting for all confounding factors, Klotho was demonstrated to be negatively associated only with metabolic syndrome (OR: 0.82, 95% CI: 0.70-0.97), hypertension (OR: 0.83, 95% CI: 0.70-0.98), and hypertriglyceridemia (OR: 0.78, 95% CI: 0.67-0.91). Subgroup and interaction analyses revealed significant interactions between age, sex, race/ethnicity, body mass index, and Klotho. Additionally, mediation analysis demonstrated that leukocytes, neutrophils and monocytes accounted for 34.78%, 31.91% and 7.13%, respectively, of the associations between Klotho and metabolic syndrome.ConclusionThe serum concentration of Klotho protein was negatively associated with metabolic syndrome, with the relationship being partly mediated by systemic immune inflammation. The findings of this research revealed that the Klotho protein may be a valuable biomarker for risk stratification and a potential therapeutic target for metabolic syndrome.
C1 [Liang, Yongzhou; Liu, Ying; Zhou, Kaiyu; Yu, Li] Sichuan Univ, West China Univ Hosp 2, Dept Pediat Cardiol, Key Lab Birth Defects & Related Dis Women & Childr, Chengdu, Peoples R China.
   [Liang, Yongzhou; Liu, Ying; Zhou, Kaiyu; Yu, Li] Sichuan Univ, West China Univ Hosp 2, Dept Pediat Cardiol, Chengdu 610041, Sichuan, Peoples R China.
   [Tan, Qin] Mianzhu Peoples Hosp, Dept Endocrine, Mianzhu, Peoples R China.
   [Wu, Yurong] Shanghai Jiao Tong Univ, Xinhua Hosp, Sch Med, Dept Pediat Cardiol, 1665 Kongjiang Rd, Shanghai 200092, Peoples R China.
C3 Sichuan University; Sichuan University; Shanghai Jiao Tong University
RP Yu, L (corresponding author), Sichuan Univ, West China Univ Hosp 2, Dept Pediat Cardiol, Key Lab Birth Defects & Related Dis Women & Childr, Chengdu, Peoples R China.; Yu, L (corresponding author), Sichuan Univ, West China Univ Hosp 2, Dept Pediat Cardiol, Chengdu 610041, Sichuan, Peoples R China.; Wu, YR (corresponding author), Shanghai Jiao Tong Univ, Xinhua Hosp, Sch Med, Dept Pediat Cardiol, 1665 Kongjiang Rd, Shanghai 200092, Peoples R China.
EM wuyurong@xinhuamed.com.cn; yulischuaxi@scu.edu.cn
RI Liu, ying/IUQ-7611-2023
FU National Natural Science Foundation of China
FX The authors express their sincere gratitude to the participants and
   staff of the National Health and Nutrition Examination Survey for their
   invaluable contributions to this research.
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NR 55
TC 2
Z9 2
U1 0
U2 1
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1476-511X
J9 LIPIDS HEALTH DIS
JI Lipids Health Dis.
PD NOV 5
PY 2024
VL 23
IS 1
AR 360
DI 10.1186/s12944-024-02339-y
PG 14
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA L6T2U
UT WOS:001352015000001
PM 39501238
OA gold
DA 2025-06-11
ER

PT J
AU Harris, RA
   Crandell, J
   Taylor, JY
   Santos, HP Jr
AF Harris, Rebeca Alvarado
   Crandell, Jamie
   Taylor, Jacquelyn Y.
   Santos, Hudson P.
TI Childhood Racism and Cardiometabolic Risk in Latina Mothers Across the
   First Postpartum Year
SO PSYCHOSOMATIC MEDICINE
LA English
DT Article
DE postpartum; racism; cardiometabolic; C-reactive protein; Latina;
   acculturation
ID C-REACTIVE PROTEIN; MEXICAN IMMIGRANTS; PREGNANCY OUTCOMES; OXIDATIVE
   STRESS; UNITED-STATES; LIFE STRESS; HEALTH; OBESITY; INFLAMMATION; WOMEN
AB Objective: Immigrant Latinas, particularly of Mexican descent, initially achieve healthy perinatal outcomes. Although this advantage wears off across generations in the United States (US), the early life psychosocial mechanisms that may initiate a cascade of biological vulnerabilities remain elusive. The current investigation aimed to understand the extent to which childhood experiences of racism may contribute to elevated levels of C-reactive protein (CRP), an early indicator of cardiometabolic risk, during the first postpartum year. Methods: Latinas from the Community and Child Health Network (N = 457) retrospectively reported experiences of childhood racism and childhood country of residence via structured questionnaires. Interviewers collected CRP bloodspots and height and weight measurements for body mass index at 6 months and 1 year postpartum. Results: Latinas who grew up in the US experienced a steeper increase of CRP levels across the first postpartum year (beta = 0.131, p = .009) and had higher CRP levels 1 year postpartum than Latinas who grew up in Latin America. Based on Bayesian path analyses, Latinas who grew up in the US reported higher levels of childhood racism than Latinas who immigrated after childhood (beta = 0.27; 95% credible interval = 0.16-0.37). In turn, childhood racism mediated the relationship between country of childhood residence and elevated CRP at 6 months and 1 year postpartum, even after adjusting for sociodemographic and behavioral covariates. After adjusting for body mass index, mediational relationships became nonsignificant. Conclusions: This study is an important first step toward understanding how childhood racism may contribute to postmigratory health patterns among Latinas, particularly cardiometabolic risk 1 year after childbirth.
C1 [Harris, Rebeca Alvarado] Univ North Carolina Chapel Hill, Sch Nursing, Chapel Hill, NC USA.
   [Crandell, Jamie] Univ North Carolina Chapel Hill, Dept Biostat, Chapel Hill, NC USA.
   [Taylor, Jacquelyn Y.] Columbia Univ, Ctr Res People Color, Sch Nursing, New York, NY USA.
   [Santos, Hudson P.] Univ Miami, Hlth Studies St os, Sch Nursing, Miami, FL USA.
C3 University of North Carolina; University of North Carolina Chapel Hill;
   University of North Carolina School of Medicine; University of North
   Carolina School of Medicine; University of North Carolina; University of
   North Carolina Chapel Hill; Columbia University; University of Miami
RP Harris, RA (corresponding author), 120 N Med Dr,Carrington Hall,Campus Box 7460, Chapel Hill, NC 27599 USA.
EM rebeca@email.unc.edu; jbigelow@email.unc.edu; jyt2116@cumc.columbia.edu;
   hsantos@miami.edu
RI Santos, Hudson/C-1581-2012; Crandell, Jamie/KCX-8061-2024;
   Alvarado-Harris, Rebeca/GSJ-0508-2022
OI Alvarado Harris, Rebeca/0000-0003-1600-4850
FU Eunice Kennedy Shriver National Institute of Child Health and Human
   Development [U HD44219, U HD54791, U HD44226, U HD44226-05S1, U HD54019,
   U HD44253, R03 HD59584, UHD44245-06S1, U HD44245, U HD44, U HD44207];
   National Institute of Nursing Research (NINR) [R01NR019245,
   R01NR017199]; UNC Royster Society; Linda Waring Matthews Research Award;
   NINR [1F31NR020843];  [R01NR013520];  [R01AG081251]
FX This article is a product of the CCHN study, and data were obtained via
   the NIH Data and Specimen Hub (DASH):
   https://dash.nichd.nih.gov/study/1649. The content is solely the
   responsibility of the authors and does not represent the official views
   of the original CCHN investigators or NIH.
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NR 98
TC 0
Z9 0
U1 1
U2 7
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0033-3174
EI 1534-7796
J9 PSYCHOSOM MED
JI Psychosom. Med.
PD JUL-AUG
PY 2024
VL 86
IS 6
BP 531
EP 540
DI 10.1097/PSY.0000000000001306
PG 10
WC Psychiatry; Psychology; Psychology, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry; Psychology
GA XZ7M3
UT WOS:001265566500011
PM 38573031
DA 2025-06-11
ER

PT J
AU Hsieh, SK
   Lin, NH
   Chen, YJ
   Lee, MR
   Chen, WY
   Tzen, JTC
AF Hsieh, Sheng-Kuo
   Lin, Nan-Hei
   Chen, Ying-Jie
   Lee, Maw-Rong
   Chen, Wen-Ying
   Tzen, Jason T. C.
TI Therapeutic Effects of Lithospermate B Complexed with Mg<SUP>2+</SUP> or
   Zn<SUP>2+</SUP> on Metabolic Syndrome Induced in Rats Fed with High-Fat
   Diet
SO MOLECULES
LA English
DT Article
DE high-fat diet; insulin resistance; lithospermate B; metabolic syndrome;
   zinc
ID CAFFEIC ACID-DERIVATIVES; SALVIA-MILTIORRHIZA; INSULIN SENSITIVITY
AB Excessive food consumption and insufficient exercise lead to the prevalence of metabolic syndrome in modern life, which consequently increases the risk of many chronic diseases. Magnesium lithospermate B (MLB) from Danshen has been demonstrated to improve metabolic changes in high-fat diet-fed rats with metabolic syndrome. In this study, Mg2+ in MLB was successfully replaced with Zn2+ to form zinc lithospermate B (ZLB) complex. MLB (10 mg/kg/day) and ZLB of various concentrations (1, 2.5, 5, and 10 mg/kg/day) were prepared and examined for their therapeutic effects on metabolic syndrome induced in rats fed with a high-fat diet. The results showed that both MLB and ZLB were able to recover or alleviate the abnormal physiological states of high-fat diet-fed rats including weight gain, epididymal fat accumulation, fatty liver, retarded blood lipid and glucose metabolism putatively caused by insulin resistance, and elevated levels of proinflammatory cytokine, leptin, and oxidative stress. In an overall view of the animal study, the effectiveness of ZLB supplementation seemed to be better than that of MLB supplementation for the recovery of high-fat-fed rats from metabolic syndrome.
C1 [Hsieh, Sheng-Kuo; Chen, Ying-Jie; Tzen, Jason T. C.] Natl Chung Hsing Univ, Grad Inst Biotechnol, Taichung 402, Taiwan.
   [Lin, Nan-Hei] Yuanpei Univ Med Technol, Dept Biotechnol & Pharmaceut Technol, Hsinchu 300, Taiwan.
   [Lee, Maw-Rong] Natl Chung Hsing Univ, Dept Chem, Taichung 402, Taiwan.
   [Chen, Wen-Ying] Natl Chung Hsing Univ, Dept Vet Med, Taichung 402, Taiwan.
C3 National Chung Hsing University; National Chung Hsing University;
   National Chung Hsing University
RP Tzen, JTC (corresponding author), Natl Chung Hsing Univ, Grad Inst Biotechnol, Taichung 402, Taiwan.; Chen, WY (corresponding author), Natl Chung Hsing Univ, Dept Vet Med, Taichung 402, Taiwan.
EM vincentqaz123@gmail.com; CMNHEI@mohw.gov.tw; pp.club@msa.hinet.net;
   mrlee@dragon.nchu.edu.tw; wychen@dragon.nchu.edu.tw;
   TCTZEN@dragon.nchu.edu.tw
OI Tzen, Jason/0000-0002-4218-6363
FU  [NCHU-102D604]
FX The work was supported by a grant to JTC Tzen of National Chung-Hsing
   University (NCHU-102D604).
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NR 46
TC 3
Z9 3
U1 0
U2 15
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1420-3049
J9 MOLECULES
JI Molecules
PD FEB 2
PY 2020
VL 25
IS 4
AR 983
DI 10.3390/molecules25040983
PG 17
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA KY3EQ
UT WOS:000522454500219
PM 32098371
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Younis, W
   Aiamgeer
   Schini-Kerth, VB
   Gasparotto, A
   Majid, M
AF Younis, Waqas
   Aiamgeer
   Schini-Kerth, V. B.
   Gasparotto Junior, Arquimedes
   Majid, Muhammad
TI Cardioprotective effect of Asphodelus tenuifolius Cay. on blood
   pressure and metabolic alterations in glucose-induced metabolic syndrome
   rats-An ethnopharmacological approach
SO JOURNAL OF ETHNOPHARMACOLOGY
LA English
DT Article
ID OXIDATIVE STRESS; ANTIOXIDANT ACTIVITY; INSULIN-RESISTANCE; QUERCETIN;
   RUTIN; AMLODIPINE; CATECHIN; EXTRACT; LEAVES; PLANTS
C1 [Younis, Waqas; Aiamgeer] Univ Sargodha, Fac Pharm, Dept Pharmacol, Lab Cardiovasc Res & Integrat Pharmacol, Sargodha 40100, Pakistan.
   [Schini-Kerth, V. B.] Univ Strasbourg, CNRS, Fac Pharm, Lab Biophoton & Pharmacol,UMR 7213, Illkirch Graffenstaden, France.
   [Gasparotto Junior, Arquimedes] Fed Univ Grande Dourados UFGD, Lab Electrophysiol & Cardiovasc Pharmacol, POB 533, BR-79804970 Dourados, MS, Brazil.
   [Majid, Muhammad] Quaid I Azam Univ, Fac Biol Sci, Dept Pharm, Islamabad 44000, Pakistan.
C3 University of Sargodha; Centre National de la Recherche Scientifique
   (CNRS); CNRS - National Institute for Biology (INSB); Universites de
   Strasbourg Etablissements Associes; Universite de Strasbourg;
   Universidade Federal da Grande Dourados; Quaid I Azam University
RP Aiamgeer (corresponding author), Univ Sargodha, Fac Pharm, Dept Pharmacol, Lab Cardiovasc Res & Integrat Pharmacol, Sargodha 40100, Pakistan.
EM alam_yuchi@yahoo.com
RI Junior, Arquimedes/AAA-6161-2019; Majid, Muhammad/AAT-3355-2020
OI Majid, Muhammad/0000-0003-0237-8114; -, Dr Alamgeer/0000-0003-4775-7337;
   YOUNIS, WAQAS/0000-0001-8530-9573
FU Higher Education Commission of Pakistan; Ministry of Foreign Affairs and
   International Development (MAEDI) France; Ministry of Higher Education
   and Research (MESR) of France
FX The authors are thankful to Higher Education Commission of Pakistan,
   Ministry of Foreign Affairs and International Development (MAEDI) France
   and the Ministry of Higher Education and Research (MESR) of France for
   funding this project through PERIDOT Research Program.
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NR 40
TC 16
Z9 16
U1 0
U2 12
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0378-8741
EI 1872-7573
J9 J ETHNOPHARMACOL
JI J. Ethnopharmacol.
PD MAR 25
PY 2018
VL 214
BP 168
EP 178
DI 10.1016/j.jep.2017.12.005
PG 11
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA FX6XP
UT WOS:000426230900020
PM 29225118
DA 2025-06-11
ER

PT J
AU Basu, R
   Brar, JS
   Chengappa, KNR
   John, V
   Parepally, H
   Gershon, S
   Schlicht, P
   Kupfer, DJ
AF Basu, R
   Brar, JS
   Chengappa, KNR
   John, V
   Parepally, H
   Gershon, S
   Schlicht, P
   Kupfer, DJ
TI The prevalence of the metabolic syndrome in patients with
   schizoaffective disorder - bipolar subtype
SO BIPOLAR DISORDERS
LA English
DT Article
DE bipolar disorder; diabetes mellitus; hyperlipidemia; hypertension;
   metabolic syndrome; obesity; schizoaffective disorder; schizophrenia
ID DIABETES-MELLITUS; DISEASE; HEALTH; SCALE
AB Objectives: To evaluate the point prevalence of the metabolic syndrome in patients with schizoaffective disorder - bipolar type.
   Methods: Consenting patients who were participants in an ongoing clinical trial of adjunctive topiramate treatment for schizoaffective disorder, bipolar type were evaluated at baseline for the point prevalence of the metabolic syndrome. The criteria for the metabolic syndrome included: (a) waist circumference > 102 cm (40 inches) in males, or > 88 cm (35 inches) in females; (b) fasting serum triglyceride levels greater than or equal to 150 mg/dL; (c) fasting high density lipoproteins (HDL) cholesterol <40 mg/dL in men or <50 mg/dL in women; (d) blood pressure greater than or equal to 130/85 mmHg; and (e) fasting glucose greater than or equal to 110 mg/dL. Subjects who had at least three of these five criteria were defined as meeting criteria for the metabolic syndrome.
   Results: Thirty-six subjects (males = 15, females = 21) were evaluated, and three were excluded for missing data. Among those 33 subjects with complete data, 14 subjects (42.4%, males = 7, females = 7, African Americans = 6, Caucasians = 8) met criteria for the metabolic syndrome. Not unexpectedly, those with the metabolic syndrome were significantly more likely to be obese, and have significantly higher mean systolic and diastolic blood pressure, mean fasting triglyceride levels and larger mean waist circumferences, and significantly lower HDL cholesterol levels; and a trend toward higher fasting blood glucose levels. Furthermore, the fasting mean total cholesterol in those with the metabolic syndrome was 217 mg/dL (+/-46).
   Conclusions: This preliminary report suggests that the point prevalence of the metabolic syndrome in patients with schizoaffective disorder appears to be higher than that reported in the general population of the USA. Targeted weight reduction and life style change strategies (increased exercise, smoking cessation, stress reduction) may provide useful interventions to decrease the morbidity and mortality that accompanies the presence of the metabolic syndrome in patients with psychiatric illnesses.
C1 Univ Pittsburgh, Med Ctr, Sch Med, Western Psychiat Inst & Clin, Pittsburgh, PA 15213 USA.
   Mayview State Hosp, Special Studies Ctr, Bridgeville, PA USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE); University
   of Pittsburgh; Western Psychiatric Institute & Clinic of UPMC
RP Univ Pittsburgh, Med Ctr, Sch Med, Western Psychiat Inst & Clin, 3811 OHara St, Pittsburgh, PA 15213 USA.
EM chengappakn@upmc.edu
RI Brar, Jaspreet/J-7816-2019
CR Alexander CM, 2003, DIABETES, V52, P1210, DOI 10.2337/diabetes.52.5.1210
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NR 21
TC 103
Z9 119
U1 0
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1398-5647
EI 1399-5618
J9 BIPOLAR DISORD
JI Bipolar Disord.
PD AUG
PY 2004
VL 6
IS 4
BP 314
EP 318
DI 10.1111/j.1399-5618.2004.00126.x
PG 5
WC Clinical Neurology; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Psychiatry
GA 833RK
UT WOS:000222356100006
PM 15225149
DA 2025-06-11
ER

PT J
AU Tilinca, MC
   Barabas-Hajdu, EC
   Ferencz, GT
   Nemes-Nagy, E
AF Tilinca, Mariana Cornelia
   Barabas-Hajdu, Eniko Csilla
   Ferencz, Gizella Tusa
   Nemes-Nagy, Eniko
TI Involvement of inflammatory cytokines in obesity and its complications
SO REVISTA ROMANA DE MEDICINA DE LABORATOR
LA English
DT Article
ID ADIPOSE-TISSUE INFLAMMATION; ANGIOPOIETIN-LIKE PROTEIN-2;
   CORONARY-HEART-DISEASE; METABOLIC SYNDROME; MYOCARDIAL
   ISCHEMIA/REPERFUSION; CARTILAGE DEGRADATION; RHEUMATOID-ARTHRITIS;
   DIABETES-MELLITUS; OXIDATIVE STRESS; MURINE MODEL
C1 [Tilinca, Mariana Cornelia; Barabas-Hajdu, Eniko Csilla; Nemes-Nagy, Eniko] Univ Med & Pharm, Targu Mures, Romania.
   [Ferencz, Gizella Tusa] Univ Hosp Linkoping, Dept Internal Med & Hematol, Linkoping, Sweden.
C3 George Emil Palade University of Medicine, Pharmacy, Science, &
   Technology of Targu Mures; Linkoping University
RP Barabas-Hajdu, EC (corresponding author), Univ Med & Pharm Tirgu Mures, Targu Mures, Romania.
EM eniko.barabas@gmail.com
RI Tilinca, Mariana/NBX-6196-2025; Barabas, Barabas- Hajdu, Barabas- Hajdu,
   Eniko, Eniko-Csilla, Eniko Csilla,/AAX-3977-2021
OI TILINCA, MARIANA CORNELIA/0000-0002-4719-3036; Barabas, Barabas- Hajdu,
   Barabas- Hajdu, Eniko, Eniko-Csilla, Eniko Csilla,/0000-0002-1830-7356
FU UMPh Tirgu Mures [5068]
FX Financial support has been provided by a private research grant with the
   involvement of UMPh Tirgu Mures, contract no. 5068/26.04.2016.
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NR 91
TC 18
Z9 18
U1 3
U2 9
PU SCIENDO
PI WARSAW
PA BOGUMILA ZUGA 32A, WARSAW, MAZOVIA, POLAND
SN 1841-6624
EI 2284-5623
J9 REV ROMANA MED LAB
JI Rev. Romana Med. Lab.
PD JUL
PY 2018
VL 26
IS 3
BP 359
EP 371
DI 10.2478/rrlm-2018-0019
PG 13
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA GO9VO
UT WOS:000440456200011
OA Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Bujtor, M
   Turner, A
   Torres, SJ
   Esteban-Gonzalo, L
   Pariante, CM
   Borsini, A
AF Bujtor, Melissa
   Turner, Anne, I
   Torres, Susan J.
   Esteban-Gonzalo, Laura
   Pariante, Carmine M.
   Borsini, Alessandra
TI Associations of Dietary Intake on Biological Markers of Inflammation in
   Children and Adolescents: A Systematic Review
SO NUTRIENTS
LA English
DT Review
DE dietary intake; dietary pattern; macronutrients; biomarkers;
   inflammation; CRP; cytokine; interleukin; children; adolescent
ID C-REACTIVE PROTEIN; LOW-GRADE INFLAMMATION; WHOLE-GRAIN INTAKE;
   METABOLIC SYNDROME; SUBCLINICAL INFLAMMATION; MEDITERRANEAN DIET;
   CARDIOMETABOLIC RISK; CARDIOVASCULAR RISK; PHYSICAL-ACTIVITY; NO
   ASSOCIATION
AB Background: In children and adolescents, chronic low-grade inflammation has been implicated in the pathogenesis of co- and multi-morbid conditions to mental health disorders. Diet quality is a potential mechanism of action that can exacerbate or ameliorate low-grade inflammation; however, the exact way dietary intake can regulate the immune response in children and adolescents is still to be fully understood. Methods: Studies that measured dietary intake (patterns of diet, indices, food groups, nutrients) and any inflammatory biomarkers in children and adolescents aged 2 to19 years and published until November 2020 were included in this systematic review, and were selected in line with PRISMA guidelines through the following databases: Academic Search Complete, CINAHL, Global Health, Medline COMPLETE and Web of Science-Core Collection. A total of 53 articles were identified. Results: Results show that adequate adherence to healthful dietary patterns such as the Mediterranean diet, or food groups such as vegetables and fruit, or macro/micro nutrients such as fibre or vitamin C and E, are associated with decreased levels of pro-inflammatory biomarkers, mainly c-reactive protein (CRP), interleukin-6 (IL-6) and tumour necrosis factor-alpha (TNF-alpha), whereas adherence to a Western dietary pattern, as well as intake of food groups such as added sugars, macro-nutrients such as saturated fatty acids or ultra-processed foods, is associated with higher levels of the same pro-inflammatory biomarkers. Conclusions: This is the first systematic review examining dietary intake and biological markers of inflammation in both children and adolescents. A good quality diet, high in vegetable and fruit intake, wholegrains, fibre and healthy fats ameliorates low-grade inflammation, and therefore represents a promising therapeutic approach, as well as an important element for disease prevention in both children and adolescents.
C1 [Bujtor, Melissa; Turner, Anne, I; Torres, Susan J.] Deakin Univ, Sch Exercise & Nutr Sci, Inst Phys Act & Nutr Res, Melbourne, Vic 3125, Australia.
   [Esteban-Gonzalo, Laura] Autonomous Univ Madrid, Fac Med, Nursing Dept, Madrid 28029, Spain.
   [Pariante, Carmine M.; Borsini, Alessandra] Kings Coll London, Stress Psychiat & Immunol Lab, Dept Psychol Med, Inst Psychiat Psychol & Neurosci, London SE5 9RT, England.
C3 Deakin University; Autonomous University of Madrid; University of
   London; King's College London
RP Borsini, A (corresponding author), Kings Coll London, Stress Psychiat & Immunol Lab, Dept Psychol Med, Inst Psychiat Psychol & Neurosci, London SE5 9RT, England.
EM melissa.bujtor@deakin.edu.au; susan.torres@deakin.edu.au;
   laura.esteban@uam.es; carmine.pariante@kcl.ac.uk;
   alessandra.borsini@kcl.ac.uk
RI Bujtor, Melissa/HKV-1724-2023; Turner, Anne/ACH-8306-2022;
   Esteban-Gonzalo, Laura/ABE-3637-2021; Borsini, Alessandra/P-5180-2017;
   Pariante, Carmine Maria/B-1297-2011
OI Borsini, Alessandra/0000-0003-4410-7865; BUJTOR,
   MELISSA/0000-0003-0111-7510; Turner, Anne/0000-0002-0682-2860; Torres,
   Susan/0000-0002-2599-1934; Pariante, Carmine Maria/0000-0002-9132-5091
FU UK Medical Research Council [MR/L014815/1, MR/J002739/1, MR/N029488/1];
   European Commission [SC1-BHC-012019]; National Institute for Health
   Research (NIHR) Biomedical Research Centre at South London and Maudsley
   NHS Foundation Trust and King's College London; Johnson and Johnson;
   Wellcome Trust [104025]; Janssen; GlaxoSmithKline; Lundbeck; Pfizer; MRC
   [MR/J002739/1, MR/N029488/1, G108/603, MR/L014815/1] Funding Source:
   UKRI
FX A.B. and C.M.P. are funded by the UK Medical Research Council (grants
   MR/L014815/1, MR/J002739/1and MR/N029488/1), the European Commission
   Horizon 2020 (grant SC1-BHC-012019) and the National Institute for
   Health Research (NIHR) Biomedical Research Centre at South London and
   Maudsley NHS Foundation Trust and King's College London; they have also
   received research funding from Johnson and Johnson for research on
   depression and inflammation, but this paper is independent from this
   funding. In addition, C.M.P. is funded by the Wellcome Trust strategy
   award to the Neuroimmunology of Mood Disorders and Alzheimer's Disease
   (NIMA) Consortium (104025), which is also funded by Janssen,
   GlaxoSmithKline, Lundbeck and Pfizer, but, again, this paper is
   independent from this funding.
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NR 122
TC 61
Z9 63
U1 4
U2 44
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD FEB
PY 2021
VL 13
IS 2
AR 356
DI 10.3390/nu13020356
PG 29
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA QO1CN
UT WOS:000622884900001
PM 33503979
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Astle, F
AF Astle, Fredrick
TI Diabetes and depression: A review of the literature
SO NURSING CLINICS OF NORTH AMERICA
LA English
DT Review
ID CO-MORBID DEPRESSION; COMORBID DEPRESSION; INCREASED RISK; TYPE-2;
   SYMPTOMS; MELLITUS; ASSOCIATION; PREVALENCE; MORTALITY; ADULTS
AB Depression affects millions of people in the United States. Drugs used to treat depression can lead to weight gain, which could predispose a person to type 2 diabetes. Also, certain medications that may be used to treat depression with psychotic features can lead to metabolic syndrome and new-onset diabetes. Diabetes is another chronic health care condition that affects millions of people in the United States. Diabetes is the leading cause of nontraumatic amputations and a leading cause of blindness. Both conditions can result in a lower quality of life. Clinicians face challenges in treating either condition, but can face greater ones when the conditions occur together. This article reviews the literature concerning depression and diabetes.
C1 MedCent Coll Nursing, Mansfield, OH 44903 USA.
RP Astle, F (corresponding author), MedCent Coll Nursing, 335 Glessner Ave, Mansfield, OH 44903 USA.
EM fastle@medcentral.edu
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NR 36
TC 11
Z9 18
U1 0
U2 11
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0029-6465
EI 1558-1357
J9 NURS CLIN N AM
JI Nurs. Clin. North Am.
PD MAR
PY 2007
VL 42
IS 1
BP 67
EP +
DI 10.1016/j.cnur.2006.11.007
PG 13
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA 141WX
UT WOS:000244610800007
PM 17270591
DA 2025-06-11
ER

PT J
AU Kulawik, A
   Cielecka-Piontek, J
   Czerny, B
   Kaminski, A
   Zalewski, P
AF Kulawik, Anna
   Cielecka-Piontek, Judyta
   Czerny, Boguslaw
   Kaminski, Adam
   Zalewski, Przemyslaw
TI The Relationship Between Lycopene and Metabolic Diseases
SO NUTRIENTS
LA English
DT Review
DE lycopene; metabolic syndrome; obesity; type 2 diabetes
ID OBESITY-ASSOCIATED INFLAMMATION; OXIDATIVE STRESS; SERUM LYCOPENE;
   ADIPOSE-TISSUE; INSULIN-RESISTANCE; DIABETES-MELLITUS; BETA-CAROTENE;
   TOMATO-JUICE; PROTECTIVE ROLE; MESSENGER-RNA
AB Background: Metabolic syndrome, obesity, and type 2 diabetes are closely related. They are characterized by chronic inflammation and oxidative stress. Obesity is the most important risk factor for metabolic syndrome and type 2 diabetes. Metabolic syndrome is characterized by insulin resistance and elevated blood glucose levels, among other conditions. These disorders contribute to the development of type 2 diabetes, which can exacerbate other metabolic problems. Methods: Numerous studies indicate that diet and nutrients can have a major impact on preventing and treating these conditions. One such ingredient is lycopene. It is a naturally occurring carotenoid with a unique chemical structure. It exhibits strong antioxidant and anti-inflammatory properties due to its conjugated double bonds and its ability to neutralize reactive oxygen species. Its properties make lycopene indirectly affect many cellular processes. The article presents studies in animal models and humans on the activity of this carotenoid in metabolic problems. Results: The findings suggest that lycopene's antioxidant and anti-inflammatory activities make it a promising candidate for the prevention and treatment of metabolic syndrome, obesity, and type 2 diabetes. Conclusions: This review underscores the potential of lycopene as a beneficial dietary supplement in improving metabolic health and reducing the risk of associated chronic diseases. The conditions described are population diseases, so research into compounds with properties such as lycopene is growing in popularity.
C1 [Kulawik, Anna; Cielecka-Piontek, Judyta; Zalewski, Przemyslaw] Poznan Univ Med Sci, Fac Pharm, Dept Pharmacognosy & Biomat, 3 Rokietnicka St, PL-60806 Poznan, Poland.
   [Kulawik, Anna] Phytopharm Kleka SA, Kleka 1, PL-63040 Nowe Miasto Nad Warta, Poland.
   [Cielecka-Piontek, Judyta] Inst Nat Fibres & Med Plants, Dept Pharmacol & Phytochem, Wojska Polskiego Str 71b, PL-60630 Poznan, Poland.
   [Czerny, Boguslaw] Pomeranian Med Univ, Dept Gen Pharmacol & Pharmacoecon, PL-71210 Szczecin, Poland.
   [Kaminski, Adam] Pomeranian Med Univ, Dept Orthopaed & Traumatol, Independent Publ Clin Hosp 1, Unii Lubelskiej 1, PL-71252 Szczecin, Poland.
C3 Poznan University of Medical Sciences; Institute of Natural Fibres &
   Medicinal Plants; Pomeranian Medical University; Pomeranian Medical
   University
RP Zalewski, P (corresponding author), Poznan Univ Med Sci, Fac Pharm, Dept Pharmacognosy & Biomat, 3 Rokietnicka St, PL-60806 Poznan, Poland.
EM anna.kulawik@student.ump.edu.pl; jpiontek@ump.edu.pl;
   boguslaw.czerny@pum.edu.pl; adam.kaminski@pum.edu.pl;
   pzalewski@ump.edu.pl
RI Zalewski, Przemyslaw/K-1784-2014
OI Zalewski, Przemyslaw/0000-0002-5116-9426; Cielecka-Piontek,
   Judyta/0000-0003-0891-5419; Kulawik, Anna/0000-0002-4063-7829
FU Ministry of Science and Higher Education;  [DWD/6/0002/2022]
FX This research was funded by the Ministry of Science and Higher
   Education, grant number DWD/6/0002/2022.
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NR 174
TC 3
Z9 3
U1 21
U2 23
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD NOV
PY 2024
VL 16
IS 21
AR 3708
DI 10.3390/nu16213708
PG 26
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA L6I4M
UT WOS:001351732200001
PM 39519540
OA gold
DA 2025-06-11
ER

PT J
AU Zelber-Sagi, S
   Toker, S
   Armon, G
   Melamed, S
   Berliner, S
   Shapira, I
   Halpern, Z
   Santo, E
   Shibolet, O
AF Zelber-Sagi, S.
   Toker, S.
   Armon, G.
   Melamed, S.
   Berliner, S.
   Shapira, I.
   Halpern, Z.
   Santo, E.
   Shibolet, O.
TI Elevated alanine aminotransferase independently predicts new onset of
   depression in employees undergoing health screening examinations
SO PSYCHOLOGICAL MEDICINE
LA English
DT Article
DE Alanine aminotransferase; depression; non-alcoholic fatty liver disease;
   prospective cohort studies
ID FATTY LIVER-DISEASE; QUALITY-OF-LIFE; INSULIN-RESISTANCE;
   PHYSICAL-ACTIVITY; PRIMARY-CARE; HEPATITIS-B; METABOLIC SYNDROME;
   RISK-FACTORS; PREVALENCE; INFLAMMATION
AB Background. Non-alcoholic fatty liver disease (NAFLD) is the most common cause of elevated alanine aminotransferase (ALT). NAFLD is associated with insulin resistance and hepatic inflammation. Similarly, patients with depression exhibit insulin resistance and increased inflammatory markers. However, no study has shown a clear association between elevated ALT and the development of depression. The aim of the study was to test whether elevated ALT, a surrogate marker for NAFLD, predicts the development of depression.
   Method. The present prospective cohort study investigated 12180 employed adults referred for health examinations that included fasting blood tests and anthropometric measurements between 2003 and 2010. Exclusion criteria were: baseline minor/major depression, excessive alcohol consumption and other causes for ALT elevation. Depression was evaluated by the eight-item Patient Health Questionnaire (PHQ-8) score.
   Results. The final cohort included 5984 subjects [69.4% men, aged 45.0 (S. D. = 10.24) years]. The incidence rate of minor and major depression was 3.8% and 1.4%, respectively. Elevated ALT was a significant independent predictor for the occurrence of minor [odds ratio (OR) 2.02, 95% confidence interval (CI) 1.40-2.92] and major (OR 3.132, 95% CI 1.81-5.40) depression after adjusting for age, gender, body mass index, education level, serum levels of lipids, glucose, smoking and physical activity. Adding subjective health and affective state parameters (sleep disturbances, self-rated health, anxiety and burnout) as potential mediators only slightly ameliorated the association. Persistently elevated ALT was associated with the greatest risk for minor or major depression as compared with elevation only at baseline or follow-up (p for trend < 0.001).
   Conclusions. Elevated ALT was associated with developing depressive symptoms, thus suggesting that NAFLD may represent an independent modifiable risk factor for depression.
C1 [Zelber-Sagi, S.; Halpern, Z.; Santo, E.; Shibolet, O.] Tel Aviv Univ, Tel Aviv Sourasky Med Ctr, Dept Gastroenterol, Liver Unit, IL-69978 Tel Aviv, Israel.
   [Zelber-Sagi, S.] Univ Haifa, Sch Publ Hlth, IL-31999 Haifa, Israel.
   [Toker, S.] Tel Aviv Univ, Fac Management, Dept Org Behav, IL-69978 Tel Aviv, Israel.
   [Armon, G.] Univ Haifa, Fac Social Sci, Dept Psychol, IL-31999 Haifa, Israel.
   [Melamed, S.] Acad Coll Tel Aviv Yaffo, Tel Aviv, Israel.
   [Melamed, S.; Berliner, S.; Shapira, I.; Halpern, Z.; Santo, E.; Shibolet, O.] Tel Aviv Univ, Sackler Fac Med, IL-69978 Tel Aviv, Israel.
   [Berliner, S.; Shapira, I.] Tel Aviv Univ, Tel Aviv Sourasky Med Ctr, Internal Med Dept E, IL-69978 Tel Aviv, Israel.
C3 Tel Aviv University; Sackler Faculty of Medicine; Tel Aviv Sourasky
   Medical Center; University of Haifa; Tel Aviv University; University of
   Haifa; Tel Aviv University; Sackler Faculty of Medicine; Tel Aviv
   University; Sackler Faculty of Medicine; Tel Aviv Sourasky Medical
   Center
RP Shibolet, O (corresponding author), Tel Aviv Univ, Tel Aviv Sourasky Med Ctr, Dept Gastroenterol, Liver Unit, IL-69978 Tel Aviv, Israel.
EM orensh@tasmc.health.gov.il
RI Maharshak, Nitsan/AAK-5288-2020; Toker, Sharon/P-5428-2015
OI Toker, Sharon/0000-0001-7621-6607
FU Israel Science Foundation [788/09]; Israel National Institute for Health
   Policy and Health Services Research [2009/41/A]
FX This study was supported by grant no. 788/09 from the Israel Science
   Foundation, and by grant 2009/41/A from the Israel National Institute
   for Health Policy and Health Services Research.
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NR 78
TC 24
Z9 25
U1 1
U2 18
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
SN 0033-2917
EI 1469-8978
J9 PSYCHOL MED
JI Psychol. Med.
PD DEC
PY 2013
VL 43
IS 12
BP 2603
EP 2613
DI 10.1017/S0033291713000500
PG 11
WC Psychology, Clinical; Psychiatry; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA 251QL
UT WOS:000326944900013
PM 23522007
DA 2025-06-11
ER

PT J
AU Sánchez-Carro, Y
   de la Torre-Luque, A
   Portella, MJ
   Leal-Leturia, I
   Salvat-Pujol, N
   Massaneda, C
   de Arriba-Arnau, A
   Urretavizcaya, M
   Peretó, M
   Toll, A
   Martínez-Ruiz, A
   Ferreiros-Martinez, R
   Alvarez, P
   Soria, V
   López-García, P
AF Sanchez-Carro, Yolanda
   de la Torre-Luque, Alejandro
   Portella, Maria J.
   Leal-Leturia, Itziar
   Salvat-Pujol, Neus
   Massaneda, Clara
   de Arriba-Arnau, Aida
   Urretavizcaya, Mikel
   Pereto, Mar
   Toll, Alba
   Martinez-Ruiz, Antonio
   Ferreiros-Martinez, Raquel
   Alvarez, Pilar
   Soria, Virginia
   Lopez-Garcia, Pilar
TI Relationship between immunometabolic status and cognitive performance
   among major depression disorder patients
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE Major depressive disorder; Inflammation, Oxidative stress; Metabolic
   Syndrome; Cognitive performance
ID C-REACTIVE PROTEIN; METABOLIC SYNDROME; PHYSICAL-ACTIVITY; UNIPOLAR
   DEPRESSION; LIPID-PEROXIDATION; OLDER-ADULTS; RISK; INFLAMMATION;
   SYMPTOMS; BRAIN
AB Background: Alterations in cognitive performance have been described in patients with major depressive disorder (MDD). However, the specific risk factors of these changes are not yet known. This study aimed to explore whether inmunometabolic parameters are related to cognitive performance in MDD in comparison to healthy controls (HC)
   Methods: Sample consisted of 84 MDD patients and 78 HC. Both groups were compared on the results of cognitive performance measured with the Cambridge Neuropsychological Test Automated Battery (CANTAB), the presence of metabolic syndrome (MetS) and an inflammatory/oxidative index calculated by a principal component analysis of peripheral biomarkers (tumor necrosis factor, C-reactive protein and 4-hydroxynonenal). A multiple linear regression was carried out, to study the relationship between inmunometabolic variables and the global cognitive performance, being the latter the dependent variable.
   Results: Significant differences were obtained in the inflammatory/oxidative index between both groups (F-(1157)= 12.93; p < .001), also in cognitive performance (F-(1157)= 56.75; p < .001). The inmunometabolic covariate regression model (i.e., condition (HC/MDD), sex, age and medication loading, MetS, inflammatory/oxidative index and the interaction between MetS and inflammatory/oxidative index) was statistically significant (F-(7157)= 11.24; p < .01) and explained 31% of variance. The condition, being either MDD or HD, (B= -0.97; p < .001), age (B=-0.28; p < .001) and the interaction between inflammatory/oxidative index and MetS (B=-0.38; p = .02) were factors associated to cognitive performance.
   Limitations: Sample size was relatively small. The cross-sectional design of the study limits the possibilities of analysis.
   Conclusions: Our results provide evidence on the conjoint influence of metabolic and inflammatory dysregulation on cognitive dysfunction in MDD patients. In this way, our study opens a line of research in immunometabolic agents to deal with cognitive decline associated with MDD.
C1 [Sanchez-Carro, Yolanda; Leal-Leturia, Itziar; Lopez-Garcia, Pilar] Univ Autonoma Madrid UAM, Dept Psychiat, Madrid, Spain.
   [Sanchez-Carro, Yolanda; Leal-Leturia, Itziar; Lopez-Garcia, Pilar] Inst Invest Sanitaria Princesa IIS IP, Dept Psychiat, Madrid, Spain.
   [Sanchez-Carro, Yolanda; de la Torre-Luque, Alejandro; Portella, Maria J.; Leal-Leturia, Itziar; Urretavizcaya, Mikel; Soria, Virginia; Lopez-Garcia, Pilar] Carlos III Hlth Inst, Ctr Biomed Res Mental Hlth CIBERSAM, Madrid, Spain.
   [de la Torre-Luque, Alejandro] Univ Complutense Madrid, Dept Legal Med Psychiat & Pathol, Madrid, Spain.
   [Portella, Maria J.] Univ Autonoma Barcelona UAB, Biomed Res Inst St Pau IIB St Pau, Barcelona, Spain.
   [Salvat-Pujol, Neus; Massaneda, Clara; de Arriba-Arnau, Aida; Urretavizcaya, Mikel; Soria, Virginia] Bellvitge Univ Hosp, Bellvitge Biomed Res Inst IDIBELL, Dept Psychiat, Neurosci Grp Psychiat & Mental Hlth, Barcelona, Spain.
   [Salvat-Pujol, Neus] Corporacio Sanitaria Parc Tauli, Dept Mental Hlth, Sabadell, Spain.
   [Urretavizcaya, Mikel; Soria, Virginia] Univ Barcelona UB, Sch Med, Dept Clin Sci, Barcelona, Spain.
   [Pereto, Mar] Inia Neural SL, Castellon de La Plana, Spain.
   [Toll, Alba; Alvarez, Pilar] Hosp Mar, Inst Neuropsychiat & Addict, IMIM, Barcelona, Spain.
   [Martinez-Ruiz, Antonio] Hosp Univ Santa Cristina, Inst Invest Sanitaria Princesa IIS IP, Unidad Invest, Madrid, Spain.
   [Ferreiros-Martinez, Raquel] Hosp Univ Princesa, Inst Invest Sanitaria Princesa IIS IP, Serv Clin Anal, Madrid, Spain.
C3 CIBER - Centro de Investigacion Biomedica en Red; CIBERSAM; Complutense
   University of Madrid; Hospital Universitari Vall d'Hebron; Autonomous
   University of Barcelona; Institut d'Investigacio Biomedica de Bellvitge
   (IDIBELL); Bellvitge University Hospital; University of Barcelona;
   Autonomous University of Barcelona; Parc Tauli Hospital Universitari;
   University of Barcelona; Hospital del Mar Research Institute; Hospital
   del Mar; Hospital de La Princesa
RP López-García, P (corresponding author), Univ Autonoma Madrid UAM, Dept Psychiat, Madrid, Spain.; López-García, P (corresponding author), Inst Invest Sanitaria Princesa IIS IP, Dept Psychiat, Madrid, Spain.; López-García, P (corresponding author), Carlos III Hlth Inst, Ctr Biomed Res Mental Hlth CIBERSAM, Madrid, Spain.; López-García, P (corresponding author), Univ Autonoma Madrid, Sch Med, Dept Psychiat, 4 Arzobispo Morcillo St, Madrid 28029, Spain.
EM p.lopez@uam.es
RI Portella, Maria/H-5909-2019; Sanchez Carro, Yolanda/AAC-9898-2022;
   Salvat-Pujol, Neus/AAQ-5028-2020; Lopez-Garcia, Pilar/F-5934-2013;
   Alvarez, Pilar/JAC-0258-2023; de la Torre-Luque,
   Alejandro/AAJ-3508-2020; Martinez-Ruiz, Antonio/A-5672-2009; Toll,
   Alba/O-1512-2015
OI Martinez-Ruiz, Antonio/0000-0001-5394-9824; Alvarez,
   Pilar/0000-0002-6648-3493; Portella, Maria J/0000-0002-2007-9516;
   Pereto, Mar/0000-0002-8562-3383; Soria, Virginia/0000-0001-6412-6831;
   Toll, Alba/0000-0003-2399-5250; Massaneda-Tuneu,
   Clara/0000-0003-4385-0518; Sanchez, Yolanda/0000-0002-8644-9436;
   Salvat-Pujol, Neus/0000-0001-5320-331X
FU Carlos III Health Institute through the Ministry of Science, Innovation
   and Universities [PI15/00662, PI15/0039, PI15/00204, PI19/01040];
   European Regional Development Fund (ERDF) "A way to build Europe",
   CIBERSAM; Catalan Agency for the Management of University and Research
   Grants [AGAUR 2017 SGR 1247]; Carlos III Health Institute through the
   Spanish Ministry of Health [CP16/00020]; Universidad Autonoma de Madrid
   [FPI 2016/17]
FX This study was supported in part by grants from the Carlos III Health
   Institute through the Ministry of Science, Innovation and Universities
   (PI15/00662, PI15/0039, PI15/00204, PI19/01040), co-funded by the
   European Regional Development Fund (ERDF) "A way to build Europe",
   CIBERSAM, and the Catalan Agency for the Management of University and
   Research Grants (AGAUR 2017 SGR 1247). We also thank CERCA
   Programme/Generalitat de Catalunya for institutional support. The
   funders had no role in the study design, data collection and analysis,
   decision to publish, or preparation of the manuscript. MJP was funded
   with a Miguel Servet II contract until 2020 (CP16/00020) from the Carlos
   III Health Institute through the Spanish Ministry of Health. YSC work is
   supported by the FPI predoctoral grant (FPI 2016/17) from Universidad
   Autonoma de Madrid.
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NR 88
TC 3
Z9 4
U1 0
U2 7
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
EI 1873-3360
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD MAR
PY 2022
VL 137
AR 105631
DI 10.1016/j.psyneuen.2021.105631
EA DEC 2021
PG 9
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA XX4RU
UT WOS:000736285700002
PM 34929555
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Lee, HS
   Leem, S
   Oh, B
   Park, T
AF Lee, Ho-Sun
   Leem, Sangseob
   Oh, Bermseok
   Park, Taesung
TI Effect of Interaction between Early Menarche and Genetic Polymorphisms
   on Triglyceride
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Article
ID METABOLIC SYNDROME; SIGNALING PATHWAY; RISK-FACTORS; AGE; ASSOCIATION;
   WOMEN; HYPERTRIGLYCERIDEMIA; IDENTIFICATION; POPULATION; ESTROGEN
AB Early menarche has been associated with increased risk of metabolic syndrome. Therefore, investigating the association of each component of metabolic syndrome with age at menarche, and interactions between them, might lead to a better understanding of metabolic syndrome pathogenesis. In this study, we evaluated age at menarche for risk of metabolic syndrome and associations with its components. As a result, the risk of MetS incidence was significantly increased only at <= 12 years of age at menarche (OR = 1.91, P < 0.05). Women with early menarche (<= 12 years) had significantly higher levels of triglycerides (beta coefficient = 37.83, P = 0.02). In addition, hypertriglyceridemia was significantly increased at early menarche with 1.99 (95% CI: 1.16-3.41, P < 0.01). With GWAS-based pathway analysis, we found the type 2 diabetes mellitus, stress-activated protein kinase signaling, and Jun amino-terminal kinase cascade pathways (all nominal P < 0.001, all FDR < 0.05) to he significantly involved with early menarche on triglyceride levels. These findings may help us understand the role of early menarche on triglyceride and interaction between gene and early menarche on triglyceride for the development of metabolic syndrome.
C1 [Lee, Ho-Sun; Leem, Sangseob; Park, Taesung] Seoul Natl Univ, Interdisciplinary Program Bioinformat, 1 Kwanak Ro, Seoul 151747, South Korea.
   [Lee, Ho-Sun; Leem, Sangseob; Park, Taesung] Seoul Natl Univ, Dept Stat, 1 Kwanak Ro, Seoul 151747, South Korea.
   [Oh, Bermseok] Kyung Hee Univ, Sch Med, Dept Biochem & Mol Biol, Seoul 02447, South Korea.
C3 Seoul National University (SNU); Seoul National University (SNU); Kyung
   Hee University
RP Park, T (corresponding author), Seoul Natl Univ, Interdisciplinary Program Bioinformat, 1 Kwanak Ro, Seoul 151747, South Korea.; Park, T (corresponding author), Seoul Natl Univ, Dept Stat, 1 Kwanak Ro, Seoul 151747, South Korea.
EM tspark@stats.snu.ac.kr
RI Lee, Ho-Sun/AAD-6112-2019; Leem, Sangseob/ADI-0729-2022
OI Park, Taesung/0000-0002-8294-590X; Oh, Bermseok/0000-0002-4199-0608;
   Leem, Sangseob/0000-0001-9911-9279; Lee, Ho-Sun/0000-0003-2864-015X
FU Bio & Medical Technology Development Program of the National Research
   Foundation of Korea (NRF) [2013M3A9C4078158]; Korea Health Technology
   R&D Project through the Korea Health Industry Development Institute
   (KHIDI) - Ministry of Health & Welfare, Republic of Korea [HI16C2037,
   HI15C2165, HI16C2048]
FX This work was supported by the Bio & Medical Technology Development
   Program of the National Research Foundation of Korea (NRF) grant
   (2013M3A9C4078158) and by grants of the Korea Health Technology R&D
   Project through the Korea Health Industry Development Institute (KHIDI),
   funded by the Ministry of Health & Welfare, Republic of Korea (grant
   numbers HI16C2037, HI15C2165 and HI16C2048).
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NR 49
TC 4
Z9 4
U1 0
U2 2
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PY 2019
VL 2019
AR 9148920
DI 10.1155/2019/9148920
PG 9
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA HO4TK
UT WOS:000460915300001
PM 30931082
OA Green Published, Green Submitted, hybrid
DA 2025-06-11
ER

PT J
AU Taghipour, YD
   Hajialyani, M
   Naseri, R
   Hesari, M
   Mohammadi, P
   Stefanucci, A
   Mollica, A
   Farzaei, MH
   Abdollahi, M
AF Taghipour, Yasamin Davatgaran
   Hajialyani, Marziyeh
   Naseri, Rozita
   Hesari, Mahvash
   Mohammadi, Pantea
   Stefanucci, Azzurra
   Mollica, Adriano
   Farzaei, Mohammad Hosein
   Abdollahi, Mohammad
TI Nanoformulations of natural products for management of metabolic
   syndrome
SO INTERNATIONAL JOURNAL OF NANOMEDICINE
LA English
DT Review
DE nanoformulation; natural products; metabolic syndrome; diabetes
ID ACTIVATED RECEPTOR-GAMMA; INSULIN-RESISTANCE; LIPID-METABOLISM; NUCLEAR
   RECEPTORS; IN-VITRO; ENDOTHELIAL FUNCTION; STEVIA-REBAUDIANA;
   SILYBUM-MARIANUM; OXIDATIVE STRESS; PROTEIN-KINASE
AB Metabolic syndrome is a common metabolic disorder which has become a public health challenge worldwide. There has been growing interest in medications including natural products as complementary or alternative choices for common chemical therapeutics regarding their limited side effects and ease of access. Nanosizing these compounds may help to increase their solubility, bioavailability, and promisingly enhance their efficacy. This study, for the first time, provides a comprehensive overview of the application of natural-products-based nanoformulations in the management of metabolic syndrome. Different phytochemicals including curcumin, berberine, Capsicum oleoresin, naringenin, emodin, gymnemic acid, resveratrol, quercetin, scutellarin, stevioside, silybin, baicalin, and others have been nanosized hitherto, and their nanosizing method and effect in treatment and alleviating metabolic syndrome have been reviewed and discussed in this study. It has been discovered that there are several pathways or molecular targets relevant to metabolic disorders which are affected by these compounds. Various natural-based nanoformulations have shown promising effect in treatment of metabolic syndrome, and therefore can be considered as future candidates instead of or in conjunction with pharmaceutical drugs if they pass clinical trials successfully.
C1 [Taghipour, Yasamin Davatgaran] Tabriz Univ Med Sci, Sch Adv Med Sci, Dept Med Nanotechnol, Tabriz, Iran.
   [Taghipour, Yasamin Davatgaran] USERN, Phytopharmacol Interest Grp PPIG, Tehran, Iran.
   [Taghipour, Yasamin Davatgaran] Tabriz Univ Med Sci, Student Res Comm, Tabriz, Iran.
   [Hajialyani, Marziyeh; Farzaei, Mohammad Hosein] Kermanshah Univ Med Sci, Hlth Inst, Pharmaceut Sci Res Ctr, Kermanshah, Iran.
   [Naseri, Rozita] Kermanshah Univ Med Sci, Internal Med Dept, Fac Med, Kermanshah, Iran.
   [Hesari, Mahvash; Mohammadi, Pantea] Kermanshah Univ Med Sci, Med Biol Res Ctr, Kermanshah, Iran.
   [Stefanucci, Azzurra; Mollica, Adriano] G dAnnunzio Univ Chieti Pescara, Dept Pharm, I-66100 Chieti, Italy.
   [Abdollahi, Mohammad] Tehran Univ Med Sci, Toxicol & Dis Grp, Inst Pharmaceut Sci TIPS, Tehran 1417614411, Iran.
   [Abdollahi, Mohammad] Tehran Univ Med Sci, Fac Pharm, Tehran 1417614411, Iran.
C3 Tabriz University of Medical Science; Tabriz University of Medical
   Science; Kermanshah University of Medical Sciences; Kermanshah
   University of Medical Sciences; Kermanshah University of Medical
   Sciences; G d'Annunzio University of Chieti-Pescara; Tehran University
   of Medical Sciences; Tehran University of Medical Sciences
RP Farzaei, MH (corresponding author), Kermanshah Univ Med Sci, Hlth Inst, Pharmaceut Sci Res Ctr, Kermanshah, Iran.; Abdollahi, M (corresponding author), Tehran Univ Med Sci, Toxicol & Dis Grp, Inst Pharmaceut Sci TIPS, Tehran 1417614411, Iran.; Abdollahi, M (corresponding author), Tehran Univ Med Sci, Fac Pharm, Tehran 1417614411, Iran.
EM mh.farzaei@gmail.com; Mohammad@TUMS.Ac.Ir
RI Farzaei, Mohammad/M-5779-2017; Mollica, Adriano/K-2747-2016; Naseri,
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OI Hesari, Mahvash/0000-0001-5884-0844; /0000-0003-0123-1209; Stefanucci,
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NR 158
TC 75
Z9 79
U1 1
U2 12
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-2013
J9 INT J NANOMED
JI Int. J. Nanomed.
PY 2019
VL 14
BP 5303
EP 5321
DI 10.2147/IJN.S213831
PG 19
WC Nanoscience & Nanotechnology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics; Pharmacology & Pharmacy
GA IK8GU
UT WOS:000476833300001
PM 31406461
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Brody, GH
   Yu, TY
   Miller, GE
   Ehrlich, KB
   Chen, E
AF Brody, Gene H.
   Yu, Tianyi
   Miller, Gregory E.
   Ehrlich, Katherine B.
   Chen, Edith
TI John Henryism Coping and Metabolic Syndrome Among Young Black Adults
SO PSYCHOSOMATIC MEDICINE
LA English
DT Article
DE black; health disparities; John Henryism; metabolic syndrome;
   socioeconomic status; young adulthood
ID ALLOSTATIC LOAD; CHILDHOOD; STRESS; HEALTH
AB Objective The aim of the study was to test the novel hypothesis that, among black Americans who used John Henryism coping, those from low socioeconomic status backgrounds would be more likely to develop metabolic syndrome than those from higher socioeconomic backgrounds.
   Methods This is an ancillary analysis of Strong African American Families Healthy Adult Program, a longitudinal cohort of 391 black youths and their caregivers. From ages 11 to 18 years, family socioeconomic status was assessed. At age 25 years, John Henryism was assessed, blood samples were drawn, and measurements were taken of blood pressure and waist circumference. Metabolic syndrome status was based on International Diabetes Federation guidelines.
   Results A significant interaction emerged between family socioeconomic disadvantage and John Henryism coping in predicting metabolic syndrome diagnosis (odds ratio = 1.047, 95% confidence interval = 1.004-1.091). Participants who were high in John Henryism coping were more likely to display metabolic syndrome if they were from disadvantaged backgrounds (predicted prevalence of 26.7%) than if they were from more privileged backgrounds (predicted prevalence of 9.6%).
   Conclusions These patterns illustrate for the first time that John Henryism coping can undermine cardiometabolic health among black youths from disadvantaged backgrounds.
C1 [Brody, Gene H.; Yu, Tianyi; Ehrlich, Katherine B.] Univ Georgia, Ctr Family Res, 1095 Coll Stn Rd, Athens, GA 30602 USA.
   [Miller, Gregory E.; Chen, Edith] Northwestern Univ, Dept Psychol, Evanston, IL USA.
   [Miller, Gregory E.; Chen, Edith] Northwestern Univ, Inst Policy Res, Evanston, IL USA.
   [Ehrlich, Katherine B.] Univ Georgia, Dept Psychol, Athens, GA 30602 USA.
C3 University System of Georgia; University of Georgia; Northwestern
   University; Northwestern University; University System of Georgia;
   University of Georgia
RP Brody, GH (corresponding author), Univ Georgia, Ctr Family Res, 1095 Coll Stn Rd, Athens, GA 30602 USA.
EM gbrody@uga.edu
RI Ehrlich, Katherine/AAF-4687-2020
OI Miller, Gregory/0000-0002-7217-1082; Yu, Tianyi/0000-0003-3087-1504
FU National Institutes of Health through the National Institute of Child
   Health and Human Development [R01 HD030588]; National Institute on Drug
   Abuse [P30 DA027827]
FX This study was supported by the National Institutes of Health through
   the National Institute of Child Health and Human Development (Grant R01
   HD030588 to G.H.B.) and the National Institute on Drug Abuse (Grant P30
   DA027827 to G.H.B.). The authors report no conflicts of interest.
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NR 20
TC 26
Z9 33
U1 0
U2 10
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0033-3174
EI 1534-7796
J9 PSYCHOSOM MED
JI Psychosom. Med.
PD FEB-MAR
PY 2018
VL 80
IS 2
BP 216
EP 221
DI 10.1097/PSY.0000000000000540
PG 6
WC Psychiatry; Psychology; Psychology, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry; Psychology
GA FV8ZE
UT WOS:000424875700011
PM 29140885
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Serafino-Agrusa, L
   Spatafora, M
   Scichilone, N
AF Serafino-Agrusa, Laura
   Spatafora, Mario
   Scichilone, Nicola
TI Asthma and metabolic syndrome: Current knowledge and future perspectives
SO WORLD JOURNAL OF CLINICAL CASES
LA English
DT Review
DE Asthma; Metabolic syndrome; Obesity; Hyperinsulinemia; Dyslipidemia
ID MITOCHONDRIAL DYSFUNCTION; AIRWAY HYPERRESPONSIVENESS; OXIDATIVE STRESS;
   STATINS ENHANCE; INCIDENT ASTHMA; ALLERGIC-ASTHMA; OBESITY; LEPTIN;
   INFLAMMATION; ADIPONECTIN
AB Asthma and obesity are epidemiologically linked; however, similar relationships are also observed with other markers of the metabolic syndrome, such as insulin resistance and dyslipidemia, which cannot be accounted for by increased body mass alone. Obesity appears to be a predisposing factor for the asthma onset, both in adults and in children. In addition, obesity could make asthma more difficult to control and to treat. Although obesity may predispose to increased Th2 in.ammation or tendency to atopy, other mechanisms need to be considered, such as those mediated by hyperglycaemia, hyperinsulinemia and dyslipidemia in the context of metabolic syndrome. The mechanisms underlying the association between asthma and metabolic syndrome are yet to be determined. In the past, these two conditions were believed to occur in the same individual without any pathogenetic link. However, the improvement in asthma symptoms following weight reduction indicates a causal relationship. The interplay between these two diseases is probably due to a bidirectional interaction. The purpose of this review is to describe the current knowledge about the possible link between metabolic syndrome and asthma, and explore potential application for future studies and strategic approaches.
C1 [Serafino-Agrusa, Laura; Spatafora, Mario; Scichilone, Nicola] Univ Palermo, Dipartimento Biomed Med Interna & Specialist, Via Trabucco 180, I-90146 Palermo, Italy.
C3 University of Palermo
RP Scichilone, N (corresponding author), Univ Palermo, Dipartimento Biomed Med Interna & Specialist, Via Trabucco 180, I-90146 Palermo, Italy.
EM nicola.scichilone@unipa.it
OI Spatafora, Mario/0000-0001-6821-5882
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NR 97
TC 53
Z9 55
U1 2
U2 9
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 7041 Koll Center Parkway, Suite 160, PLEASANTON, CA, UNITED STATES
SN 2307-8960
J9 WORLD J CLIN CASES
JI World J. Clin. Cases
PD MAR 16
PY 2015
VL 3
IS 3
BP 285
EP 292
DI 10.12998/wjcc.v3.i3.285
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA VB7SF
UT WOS:000417236200009
PM 25789301
OA Green Published, hybrid, Green Submitted
DA 2025-06-11
ER

PT J
AU Cardel, MI
   Min, YI
   Sims, M
   Musani, SK
   Dulin-Keita, A
   DeBoer, MD
   Gurka, MJ
AF Cardel, Michelle I.
   Min, Yuan-I
   Sims, Mario
   Musani, Solomon K.
   Dulin-Keita, Akilah
   DeBoer, Mark D.
   Gurka, Matthew J.
TI Association of psychosocial stressors with metabolic syndrome severity
   among African Americans in the Jackson Heart Study
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE Stress; Metabolic syndrome; Jackson heart study; African Americans;
   Adults; Cardiovascular health
ID LIFE EVENTS; DEPRESSIVE SYMPTOMS; GENDER-DIFFERENCES; BODY-COMPOSITION;
   PREVALENCE; HEALTH; RISK; SEX; EXPERIENCES; ANDROGENS
AB Introduction: Using Jackson Heart Study (JHS) data, we assessed the association between perceived psychosocial stressors and metabolic syndrome (MetS) severity in African American adults.
   Methods: Participants included 3870 African American JHS participants aged 21-95 years (63.1% women; mean age 53.8 +/- 13.0). Psychosocial stressors assessed included: major life events (MLEs); global stress; and weekly stress inventory. Each stress measure was classified into tertiles (low, medium, and high). Associations of psychosocial stressors with a sex- and race/ethnic-specific MetS severity Z-score were examined after adjustment for demographics and MetS risk factors (i.e., nutrition, physical activity, smoking status, and alcohol consumption).
   Results: Independent of lifestyle factors, participants who reported high (versus low) perceived global stress and MLEs had significantly greater MetS severity (p = .0207 and p = .0105, respectively). Weekly stress was not associated with MetS severity. Compared to men, women reported significantly higher global stress and MLEs (p < 0.0001). A significant interaction between sex and MLEs (p = .0456) demonstrated men significantly increased their MetS severity at medium levels of stress, whereas women's MetS severity was significantly increased at high levels of MLEs.
   Conclusions: In the total sample, higher reported global stress and MLEs were associated with increased risk of MetS severity, while weekly stress was not. Men's and women's stress responses to MLEs were differentially associated with MetS severity, with male MetS severity increasing significantly at lower levels of MLEs relative to women's MetS severity. These data may have implications for targeting stress-related factors in interventions to improve cardiometabolic health in African American adults.
C1 [Cardel, Michelle I.; Gurka, Matthew J.] Univ Florida, Dept Hlth Outcomes & Biomed Informat, POB 100177, Gainesville, FL 32610 USA.
   [Min, Yuan-I; Sims, Mario; Musani, Solomon K.] Univ Mississippi, Med Ctr, Dept Med, 2500 N State St, Jackson, MS 39216 USA.
   [Dulin-Keita, Akilah] Brown Univ, Sch Publ Hlth, Dept Behav & Social Sci, Box G-S121-4,121 S Main St, Providence, RI 02912 USA.
   [DeBoer, Mark D.] Univ Virginia Hlth Syst, Dept Pediat, POB 800386, Charlottesville, VA 22908 USA.
C3 State University System of Florida; University of Florida; University of
   Mississippi; University of Mississippi Medical Center; Brown University;
   University of Virginia; University of Virginia (UVA) Health System
RP Cardel, MI (corresponding author), 2197 Mowry Rd,132,POB 100177, Gainesville, FL 32610 USA.
EM mcardel@ufl.edu; ymin@umc.edu; msims2@umc.edu; smusani@umc.edu;
   alkilah_keita@brown.edu; MDD5Z@hscmail.mcc.virginia.edu;
   matthewgurka@ufl.edu
OI Min, Yuan-I/0000-0003-2470-0004
FU National Heart, Lung, and Blood Institute (NHLBI) [HHSN268201300046C,
   HHSN268201300047C, HI1SN268201300048C, HHSN268201300049C,
   HHSN268201300050C]; National Institute on Minority Health and Health
   Disparities (NIMHD); National Institutes of Health National Heart, Lung,
   and Blood Institute [R01HL120960]; National Center For Advancing
   Translational Sciences of the National Institutes of Health
   [UL1TR001427]; NIMHD [P60MD002249, U54MD008176]
FX The Jackson Heart Study is supported by contracts HHSN268201300046C,
   HHSN268201300047C, HI1SN268201300048C, HHSN268201300049C,
   HHSN268201300050C from the National Heart, Lung, and Blood Institute
   (NHLBI) and the National Institute on Minority Health and Health
   Disparities (NIMHD). This work was supported by the National Institutes
   of Health National Heart, Lung, and Blood Institute (R01HL120960) and
   the National Center For Advancing Translational Sciences of the National
   Institutes of Health (UL1TR001427). The views expressed in this
   manuscript are those of the authors and do not necessarily represent the
   views of the National Heart, Lung, and Blood Institute; the National
   Institutes of Health; or the U.S. Department of Health and Human
   Services. Dr. Sims is supported by the grants P60MD002249 and
   U54MD008176 from the NIMHD.
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NR 38
TC 16
Z9 21
U1 0
U2 7
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD APR
PY 2018
VL 90
BP 141
EP 147
DI 10.1016/j.psyneuen.2018.02.014
PG 7
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA GD8LV
UT WOS:000430764800018
PM 29494952
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Jorgensen, D
   White, GE
   Sekikawa, A
   Gianaros, P
AF Jorgensen, Dana
   White, Gretchen E.
   Sekikawa, Akira
   Gianaros, Peter
TI Higher dietary inflammation is associated with increased odds of
   depression independent of Framingham Risk Score in the National Health
   and Nutrition Examination Survey
SO NUTRITION RESEARCH
LA English
DT Article
DE Cardiovascular disease risk; Depression; Dietary inflammation; Systemic
   inflammation
ID C-REACTIVE PROTEIN; MIDDLE-AGED WOMEN; CARDIOVASCULAR-DISEASE; METABOLIC
   SYNDROME; PREDICTION; MARKERS; PATTERNS; ANXIETY; ADULTS; INDEX
AB Cardiovascular disease (CVD) may increase depression risk. Risk for future CVD, which can be estimated by the Framingham Risk Score (FRS), and depression risk are both linked to systemic inflammation. Dietary consumption of proinflammatory food can be measured using the Dietary Inflammatory Index (DII) score. We examined the potential impact of DII on depression and whether this effect is independent of FRS. We hypothesized that (1) both FRS and DII would be associated with depression (Patient Health Questionnaire-9 >= 10) and (2) associations between DII and depressive symptoms (continuous) would be mediated by FRS. Data were included from adults without CVD who were participants of the 2007-2012 National Health and Nutrition Examination Survey (n = 11 624). Using logistic regression, we tested cross-sectional associations of FRS, DII (adjusting for FRS), and joint effects of FRS and DII with depression. Finally, using the Sobel method, we tested whether FRS mediates the relationship between DII and depressive symptoms. Individuals with FRS or DII scores in the top 2 quartiles had higher odds of depressive symptoms than those in the bottom quartile. The association of DII with depressive symptoms remained after FRS adjustment. The joint effects of elevated DII and FRS were additive. There was no evidence for mediation by FRS between DII and depressive symptoms. Thus, higher DII remained associated with increased odds of depressive symptoms net CVD risk. Collectively, the joint effects of CVD risk and DII indicate that a proinflammatory diet could add to risk for depressive symptoms even in those with a high FRS. (C) 2018 Elsevier Inc. All rights reserved.
C1 [Jorgensen, Dana; White, Gretchen E.; Sekikawa, Akira] Univ Pittsburgh, Grad Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA 15260 USA.
   [Gianaros, Peter] Univ Pittsburgh, Dept Psychol, Pittsburgh, PA 15260 USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE); University
   of Pittsburgh; Pennsylvania Commonwealth System of Higher Education
   (PCSHE); University of Pittsburgh
RP Jorgensen, D (corresponding author), Univ Pittsburgh, Sch Publ Hlth, Dept Epidemiol, 130 N Bellefield St,Suite 467, Pittsburgh, PA 15213 USA.
EM Drj19@pitt.edu
RI Jorgensen, Dana/AAB-1973-2020; White, Gretchen/IQS-4125-2023;
   Stefanadis, Christodoulos/ABH-2232-2020
OI White, Gretchen/0000-0002-2772-5736; Stefanadis,
   Christodoulos/0000-0001-5974-6454; Sekikawa, Akira/0000-0002-7197-6321;
   Jorgensen, Dana/0000-0002-9594-9918
FU National Heart, Lung, and Blood Institute [T32 HL083825, R01 HL089850]
FX We would like to acknowledge the technical assistance provided by both
   Yona Keich Cloonan and Ya-Hui Yu. This work was supported by the
   National Heart, Lung, and Blood Institute (grants T32 HL083825 and R01
   HL089850). The authors have no conflicts of interest to disclose.
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NR 73
TC 42
Z9 44
U1 3
U2 20
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0271-5317
EI 1879-0739
J9 NUTR RES
JI Nutr. Res.
PD JUN
PY 2018
VL 54
BP 23
EP 32
DI 10.1016/j.nutres.2018.03.004
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nutrition & Dietetics
GA GL7PD
UT WOS:000437392900003
PM 29914664
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Greenwood, EA
   Pasch, LA
   Cedars, MI
   Legro, RS
   Eisenberg, E
   Huddleston, HG
AF Greenwood, Eleni A.
   Pasch, Lauri A.
   Cedars, Marcelle I.
   Legro, Richard S.
   Eisenberg, Esther
   Huddleston, Heather G.
CA Eunice Kennedy Shriver Natl Inst C
TI Insulin resistance is associated with depression risk in polycystic
   ovary syndrome
SO FERTILITY AND STERILITY
LA English
DT Article
DE Polycystic ovary syndrome (PCOS); depression; insulin resistance
ID HOMEOSTASIS MODEL ASSESSMENT; QUALITY-OF-LIFE; METABOLIC SYNDROME;
   GLUCOSE-TOLERANCE; WOMEN; PREVALENCE; ANXIETY; ANDROGENS; SYMPTOMS;
   OBESITY
AB Objective: To test the hypothesis that insulin resistance is associated with depression risk in polycystic ovary syndrome (PCOS).
   Design: Secondary analysis of data from a multicenter randomized trial.
   Setting: Multicenter university-based clinical practices.
   Patient(s): Seven hundred thirty-eight women with PCOS by modified Rotterdam criteria seeking pregnancy enrolled in a randomized clinical trial comparing clomiphene citrate versus letrozole.
   Intervention(s): The Primary Care Evaluation of Mental Disorders Patient Health Questionnaire was self-administered to identify depression using a validated algorithm at enrollment. Demographic and anthropometric data were collected, and serum assays were performed. Insulin resistance was estimated using the homeostatic model of insulin resistance (HOMA-IR), with a cutoff of >2.2 considered abnormal.
   Main Outcome Measure(s): Demographic, endocrine, and metabolic parameters associated with depression.
   Result(s): In a univariate logistic regression analysis, elevated HOMA-IR was associated with 2.3-fold increased odds of depression (odds ratio [OR] = 2.32; 95% confidence interval [CI], 1.28-4.21). This association remained significant after controlling for age and body mass index (adjusted OR [aOR] = 2.23; 95% CI, 1.11-4.46) and in a model including additional potential confounders (aOR = 2.03; 95% CI, 1.00-4.16).
   Conclusion(s): Insulin resistance has a strong and independent association with depression in PCOS and may serve as a physiologic mediator. Our findings corroborate a growing body of evidence linking insulin resistance to depressed mood. The association between insulin resistance and depressed mood warrants further investigation to elucidate mechanisms and identify potential therapeutic targets. (C) 2018 by American Society for Reproductive Medicine.
C1 [Greenwood, Eleni A.; Pasch, Lauri A.; Cedars, Marcelle I.; Huddleston, Heather G.] Univ Calif San Francisco, Dept Obstet Gynecol & Reprod Sci, San Francisco, CA USA.
   [Legro, Richard S.] Penn State Univ, Dept Obstet & Gynecol, Hershey, PA USA.
   [Eisenberg, Esther] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Fertil & Infertil Branch, Rockville, MD USA.
C3 University of California System; University of California San Francisco;
   Pennsylvania Commonwealth System of Higher Education (PCSHE);
   Pennsylvania State University; Penn State Health; National Institutes of
   Health (NIH) - USA; NIH Eunice Kennedy Shriver National Institute of
   Child Health & Human Development (NICHD)
RP Greenwood, EA (corresponding author), Univ Calif San Francisco, Sch Med, Dept Obstet Gynecol & Reprod Sci, Div Reprod Endocrinol & Infertil, 499 Illinois St, San Francisco, CA 94158 USA.
EM eleni.greenwood@ucsf.edu
OI Huddleston, Heather/0000-0001-5350-6951; Greenwood Jaswa,
   Eleni/0000-0003-1653-902X
FU Eunice Kennedy Shriver National Institute of Child Health and Human
   Development [U10 HD27049, U10 HD38992, U10HD055925, U10 HD39005, U10
   HD38998, U10 HD055936, U10 HD055942, U10 HD055944, U54-HD29834];
   National Center for Research Resources; National Center for Advancing
   Translational Sciences through a National Institutes of Health grant
   [UL1 TR000127]
FX Supported by grants from the Eunice Kennedy Shriver National Institute
   of Child Health and Human Development (grant nos. U10 HD27049, U10
   HD38992, U10HD055925, U10 HD39005, U10 HD38998, U10 HD055936, U10
   HD055942, U10 HD055944, and U54-HD29834); and by the National Center for
   Research Resources and the National Center for Advancing Translational
   Sciences through a National Institutes of Health grant (grant no. UL1
   TR000127).
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NR 47
TC 37
Z9 46
U1 2
U2 6
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0015-0282
EI 1556-5653
J9 FERTIL STERIL
JI Fertil. Steril.
PD JUL 1
PY 2018
VL 110
IS 1
BP 27
EP 34
DI 10.1016/j.fertnstert.2018.03.009
PG 8
WC Obstetrics & Gynecology; Reproductive Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology; Reproductive Biology
GA GM1LW
UT WOS:000437830400008
PM 29908775
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Ovaskainen, Y
   Koponen, H
   Jokelainen, J
   Keinaenen-Kiukaannniemi, S
   Kumpusalo, E
   Vanhala, M
AF Ovaskainen, Yrjoe
   Koponen, Hannu
   Jokelainen, Jari
   Keinaenen-Kiukaannniemi, Sirkka
   Kumpusalo, Esko
   Vanhala, Mauno
TI Depressive symptomatology is associated with decreased interleukin-1
   beta and increased interleukin-1 receptor antagonist levels in males
SO PSYCHIATRY RESEARCH
LA English
DT Article
DE Beck Depression Inventory; Cytokines; Depression; Interleukin-1 beta;
   Interleukin-1 receptor antagonist; Metabolic syndrome; Overweight
ID INTERFERON-ALPHA TREATMENT; MAJOR DEPRESSION; METABOLIC SYNDROME;
   PROINFLAMMATORY CYTOKINES; INVENTORY; PATHOPHYSIOLOGY; CHEMOKINES;
   SYMPTOMS; DISEASE; RISK
AB Previous studies with selected patient populations have suggested that cytokines, the immune system messengers, may play a role in the aetiology of depression. However, the data concerning the increase or decrease of the plasma cytokine levels in depression is controversial and the effects of the medications and type of depression are largely unknown. We studied the connections between plasma interleukin-1 beta (IL-1 beta) and interleukin 1 receptor antagonist (IL-1 RA) levels, and depressive symptomatology measured with the Beck Depression. Inventory in a large, middle-aged population-based sample collected from Central Finland. In addition, the effects of various medications and type of depressive symptomatology on the cytokine levels were scrutinized. In the whole study population, IL-1RA levels were higher in the subgroup with depressive symptomatology. In the males with depressive symptomatology, higher IL-1 RA levels and lower interleukin-1 beta levels were observed as compared with the non-depressed males. The IL-1RA/IL-1 beta ratio was significantly higher in males with depressive symptomatology. The IL-1RA levels were also higher and IL-1 beta levels lower in the depressed females, but the trend was not significant. The elevated IL-1RA-levels and IL-1RA/IL-1 beta ratio suggest a role for cytokines in the pathogenesis of depression. The higher IL-1RA levels may reflect an endogenous repairing process against depression. (C) 2007 Elsevier Ireland Ltd. All rights reserved.
C1 [Koponen, Hannu] Kuopio Univ Hosp, Dept Psychiat, FIN-70211 Kuopio, Finland.
   [Ovaskainen, Yrjoe] Moisio Hosp, S Savo Hosp Dist, Dept Psychiat, FIN-50520 Mikkeli, Finland.
   [Koponen, Hannu] Acad Finland, Helsinki, Finland.
   [Jokelainen, Jari; Keinaenen-Kiukaannniemi, Sirkka] Univ Oulu, Inst Hlth Sci & Gen Practice, FIN-70211 Kuopio, Finland.
   [Jokelainen, Jari; Keinaenen-Kiukaannniemi, Sirkka] Oulu Univ Hosp, Unit Gen Practice, FIN-90029 Oulu, Finland.
   [Keinaenen-Kiukaannniemi, Sirkka] Oulu Hlth Ctr, FIN-90015 Oulu, Finland.
   [Kumpusalo, Esko] Univ Kuopio, Sch Publ Hlth & Clin Nutr, Dept Family Med, FIN-70211 Kuopio, Finland.
   [Kumpusalo, Esko] Kuopio Univ Hosp, Unit Family Practice, FIN-70211 Kuopio, Finland.
   [Vanhala, Mauno] Laukaa Hlth Ctr, FIN-41431 Laukaa, Finland.
   [Vanhala, Mauno] Cent Finland Hosp Dist, FIN-40620 Jyvaskyla, Finland.
C3 Kuopio University Hospital; Research Council of Finland; University of
   Oulu; University of Oulu; University of Eastern Finland; Kuopio
   University Hospital; Central Finland Central Hospital
RP Koponen, H (corresponding author), Kuopio Univ Hosp, Dept Psychiat, POB 1777, FIN-70211 Kuopio, Finland.
EM hannujuhani.koponen@uku.fi
OI Jokelainen, Jari/0000-0003-4629-0560
FU Central Finland Hospital District (MV); Finnish Psychiatric Association
   (YO); South-Savo Cultural Foundation (YO); Academy of Finland (HK) [113
   760]
FX This work was supported by grants from the Central Finland Hospital
   District (MV), Finnish Psychiatric Association (YO), South-Savo Cultural
   Foundation (YO), and grant number 113 760 from the Academy of Finland
   (HK).
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NR 32
TC 47
Z9 50
U1 0
U2 4
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0165-1781
J9 PSYCHIAT RES
JI Psychiatry Res.
PD MAY 15
PY 2009
VL 167
IS 1-2
BP 73
EP 79
DI 10.1016/j.psychres.2007.12.004
PG 7
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 446QA
UT WOS:000266135000009
PM 19346005
DA 2025-06-11
ER

PT J
AU Orth-Gomér, K
AF Orth-Gomér, K
TI Women and heart disease:: New evidence for psychosocial, behavioral, and
   biological mediators of risk and prognosis
SO INTERNATIONAL JOURNAL OF BEHAVIORAL MEDICINE
LA English
DT Article; Proceedings Paper
CT 6th International Congress of Behavioral Medicine
CY NOV 15-18, 2000
CL BRISBANE, AUSTRALIA
ID MIDDLE-AGED WOMEN; SOCIOECONOMIC-STATUS; RATE-VARIABILITY; DEPRESSIVE
   SYMPTOMS; METABOLIC SYNDROME; SOCIAL-RELATIONS; LIPID PROFILE; STRESS;
   JOB; MORTALITY
C1 Karolinska Inst, Dept Publ Hlth Serv, S-17177 Stockholm, Sweden.
C3 Karolinska Institutet
EM k.orth-gomer@phs.ki.se
CR BarrettConnor E, 1997, CIRCULATION, V95, P252, DOI 10.1161/01.CIR.95.1.252
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NR 37
TC 4
Z9 4
U1 0
U2 2
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1070-5503
EI 1532-7558
J9 INT J BEHAV MED
JI Int. J. Behav. Med.
PY 2001
VL 8
IS 4
BP 251
EP 269
DI 10.1207/s15327558ijbm0804_1
PG 19
WC Psychology, Clinical
WE Social Science Citation Index (SSCI); Conference Proceedings Citation Index - Social Science &amp; Humanities (CPCI-SSH)
SC Psychology
GA 515JB
UT WOS:000173490900001
DA 2025-06-11
ER

PT J
AU Witasp, A
   Carrero, JJ
   Heimbürger, O
   Lindholm, B
   Hammarqvist, F
   Stenvinkel, P
   Nordfors, L
AF Witasp, A.
   Carrero, J. J.
   Heimburger, O.
   Lindholm, B.
   Hammarqvist, F.
   Stenvinkel, P.
   Nordfors, L.
TI Increased expression of pro-inflammatory genes in abdominal subcutaneous
   fat in advanced chronic kidney disease patients
SO JOURNAL OF INTERNAL MEDICINE
LA English
DT Article
DE adipose tissue; end-stage renal disease
ID NECROSIS-FACTOR-ALPHA; INSULIN-RESISTANCE SYNDROME; VISCERAL
   ADIPOSE-TISSUE; METABOLIC SYNDROME; OBESITY; STRESS; RISK;
   ATHEROSCLEROSIS; INTERLEUKIN-6; MORTALITY
AB Witasp A, Carrero JJ, Heimburger O, Lindholm B, Hammarqvist F, Stenvinkel P, Nordfors L (Karolinska Institutet, Stockholm, Sweden). Increased expression of pro-inflammatory genes in abdominal subcutaneous fat in advanced chronic kidney disease patients. J Intern Med 2011; 269: 410-419.
   Objectives.
   Low-grade systemic inflammation, oxidative stress and peripheral insulin resistance are intimately associated and contribute to the increased risk of cardiovascular complications in advanced chronic kidney disease (CKD). Because altered adipose tissue activities have previously been linked to pathophysiological processes in various inflammatory and metabolic diseases we hypothesized that the uraemic milieu in patients with CKD may interact with the adipose tissue, provoking an unfavourable shift in its transcriptional output.
   Design.
   Twenty-one adipokine mRNAs were quantified in abdominal subcutaneous adipose tissue (SAT) biopsies and serum/plasma concentrations of inflammatory markers and related protein products were measured.
   Setting.
   The study was conducted at the Karolinska University Hospital, Huddinge, and Karolinska Institutet, Stockholm, Sweden.
   Subjects.
   Thirty-seven patients with CKD [15 women, median 58 (interquartile range 49-65) years] and nine nonuraemic individuals [four women, age 62 (45-64) years] were recruited prior to initiation of peritoneal dialysis catheter insertion or elective hernia repair/laparoscopic cholecystectomy, respectively.
   Results.
   Even after correction for body mass index, SAT from patients showed a significant upregulation of inflammatory pathway genes interleukin 6 (3.0-fold, P = 0.0002) and suppressor of cytokine signalling 3 (2.5-fold, P = 0.01), as well as downregulation of leptin (2.0-fold, P = 0.03) and the oxidative stress genes uncoupling protein 2 (1.5-fold, P = 0.03) and cytochrome b-245, alpha polypeptide (1.5-fold, P = 0.005), in relation to controls.
   Conclusions.
   These gene expression differences suggest that inflammatory and oxidative stress activities may be important features of the intrinsic properties of uraemic adipose tissue, which may have significant effects on the uraemic phenotype.
C1 [Witasp, A.] L8 00 Karolinska Univ Hosp, Dept Mol Med & Surg, Karolinska Inst, Ctr Mol Med, S-17176 Stockholm, Sweden.
   [Carrero, J. J.] Karolinska Inst, Ctr Gender Med, Stockholm, Sweden.
   [Heimburger, O.; Stenvinkel, P.] Karolinska Inst, Div Renal Med, Stockholm, Sweden.
   [Lindholm, B.] Karolinska Inst, Div Baxter Novum, Stockholm, Sweden.
   [Hammarqvist, F.] Karolinska Inst, Div Surg, Dept Clin Sci Intervent & Technol CLINTEC, Stockholm, Sweden.
C3 Karolinska Institutet; Karolinska University Hospital; Karolinska
   Institutet; Karolinska Institutet; Karolinska Institutet; Karolinska
   Institutet
RP Witasp, A (corresponding author), L8 00 Karolinska Univ Hosp, Dept Mol Med & Surg, Karolinska Inst, Ctr Mol Med, S-17176 Stockholm, Sweden.
EM anna.witasp@ki.se
RI ; Lindholm, Bengt/P-1334-2017
OI Carrero, Juan Jesus/0000-0003-4763-2024; Stenvinkel,
   Peter/0000-0002-8785-4820; Heimburger, Olof/0000-0003-0901-4145;
   Lindholm, Bengt/0000-0003-4269-4293
FU EU [LSHM-CT-2006-037697]; Swedish Research Council [521-2007-3336];
   Karolinska Institutet Centre for Gender Medicine; Loo and Hans
   Ostermans' Foundation; Westman's Foundation; Ake Wiberg Foundation;
   Heart and Lung Foundation; Swedish Kidney Foundation; Baxter Healthcare;
   Karolinska Institutet faculty
FX We express our gratitude to the patients and personnel at Karolinska
   University Hospital who participated in the study. Special thanks to
   Annika Moberg and Christina Backmark for surgery planning, to Annika
   Nilsson, Ann-Christin Emmoth and Ulrika Jensen for assistance in patient
   recruitment and excellent nursing and to John Sandberg for patient
   recruitment. This study was supported by the GENECURE
   (http://www.genecure.eu) project (FP6 EU-grant LSHM-CT-2006-037697), the
   Swedish Research Council (No. 521-2007-3336), Karolinska Institutet
   Centre for Gender Medicine, Loo and Hans Ostermans' and Westman's
   Foundations, the Ake Wiberg Foundation, the Heart and Lung Foundation,
   the Swedish Kidney Foundation and Baxter Healthcare. Anna Witasp's
   doctoral grant was supported by the Karolinska Institutet faculty for
   funding of postgraduate students (KID).
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NR 56
TC 41
Z9 43
U1 0
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0954-6820
EI 1365-2796
J9 J INTERN MED
JI J. Intern. Med.
PD APR
PY 2011
VL 269
IS 4
BP 410
EP 419
DI 10.1111/j.1365-2796.2010.02293.x
PG 10
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 736OE
UT WOS:000288503200011
PM 21054584
OA Bronze
DA 2025-06-11
ER

PT J
AU Cozma, D
   Siatra, P
   Bornstein, SR
   Steenblock, C
AF Cozma, Diana
   Siatra, Panagiota
   Bornstein, Stefan R.
   Steenblock, Charlotte
TI Sensitivity of the Neuroendocrine Stress Axis in Metabolic Diseases
SO HORMONE AND METABOLIC RESEARCH
LA English
DT Article
DE HPA axis; adipose tissue; obesity; metabolic diseases
ID PITUITARY-ADRENAL AXIS; BODY-MASS INDEX; ANGIOTENSIN-ALDOSTERONE SYSTEM;
   GROWTH-FACTOR RECEPTOR; TUMOR-NECROSIS-FACTOR; INSULIN-RESISTANCE;
   CORTISOL SECRETION; VISCERAL OBESITY; BLOOD-PRESSURE; CHILD
   NEURODEVELOPMENT
AB Metabolic diseases are prevalent in modern society and have reached pandemic proportions. Metabolic diseases have systemic effects on the body and can lead to changes in the neuroendocrine stress axis, the critical regulator of the body's stress response. These changes may be attributed to rising insulin levels and the release of adipokines and inflammatory cytokines by adipose tissue, which affect hormone production by the neuroendocrine stress axis. Chronic stress due to inflammation may exacerbate these effects. The increased sensitivity of the neuroendocrine stress axis may be responsible for the development of metabolic syndrome, providing a possible explanation for the high prevalence of severe comorbidities such as heart disease and stroke associated with metabolic disease. In this review, we address current knowledge of the neuroendocrine stress axis in response to metabolic disease and discuss its role in developing metabolic syndrome.
C1 [Cozma, Diana; Siatra, Panagiota; Bornstein, Stefan R.; Steenblock, Charlotte] Tech Univ Dresden, Univ Hosp Carl Gustav Carus, Dept Med 3, Fetscherstr 74, D-01307 Dresden, Germany.
   [Bornstein, Stefan R.] Kings Coll London, Fac Life Sci & Med, Sch Cardiovasc & Metab Med & Sci, London, England.
   [Bornstein, Stefan R.] Univ Hosp Zurich USZ, Dept Endocrinol Diabetol & Clin Nutr, Zurich, Switzerland.
   [Bornstein, Stefan R.] Univ Zurich UZH, Zurich, Switzerland.
C3 Technische Universitat Dresden; Carl Gustav Carus University Hospital;
   University of London; King's College London; University of Zurich;
   University Zurich Hospital; University of Zurich
RP Steenblock, C (corresponding author), Tech Univ Dresden, Univ Hosp Carl Gustav Carus, Dept Med 3, Fetscherstr 74, D-01307 Dresden, Germany.
EM Charlotte.Steenblock@uniklinikum-dresden.de
RI Steenblock, Charlotte/C-9038-2018
OI Steenblock, Charlotte/0000-0002-9635-4860
FU Deutsche Forschungsgemeinschaft (CRC/Transregio 205 "The Adrenal:
   Central Relay in Health and Disease") [314061271]; Deutsche
   Forschungsgemeinschaft (IRTG 2251 "Immunological and cellular strategies
   in metabolic disease") [288034826]
FX Deutsche Forschungsgemeinschaft (CRC/Transregio 205 "The Adrenal:
   Central Relay in Health and Disease", project number 314061271; IRTG
   2251 "Immunological and cellular strategies in metabolic disease",
   project number 288034826)
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NR 138
TC 2
Z9 2
U1 0
U2 9
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0018-5043
EI 1439-4286
J9 HORM METAB RES
JI Horm. Metab. Res.
PD JAN
PY 2024
VL 56
IS 01
BP 65
EP 77
DI 10.1055/a-2201-6641
PG 13
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA DY5Z2
UT WOS:001135677800009
PM 38171373
DA 2025-06-11
ER

PT J
AU Ozturk, K
   Kocamuftuoglu, GO
   Karatepe, M
   Kisacam, MA
   Tektemur, NK
   Onat, E
   Ozan, IE
AF Ozturk, Kubra
   Kocamuftuoglu, Gonca Ozan
   Karatepe, Mustafa
   Kisacam, Mehmet Ali
   Tektemur, Nalan Kaya
   Onat, Elif
   Ozan, Ibrahim Enver
TI Protective effects of turmeric (Curcuma longa L.) supplementation
   on oxidative stress and metabolic parameters in rats with high-fructose
   diet-induced metabolic syndrome
SO NUTRIRE
LA English
DT Review
DE Curcuma Longa L. (Turmeric); Liver; Metabolic syndrome;
   Oxidative stress; Vitamins
ID INSULIN-RESISTANCE; CURCUMINOIDS; PLASMA; HEALTH; SERUM; ACID
AB BackgroundMetabolic syndrome (MetS) is a growing global health concern characterized by oxidative stress and metabolic dysregulation. Identifying natural compounds with therapeutic potential to mitigate these effects is essential. Antioxidant parameters are crucial in reducing oxidative stress, which is a key factor in the pathophysiology of MetS.ObjectiveThis study aimed to evaluate the protective effects of turmeric (Curcuma longa L.) supplementation on oxidative stress markers, biochemical parameters, and histological outcomes in a rat model of MetS induced by a high-sugar diet.MethodsFemale Sprague-Dawley rats (n = 32) were divided into four groups: Control, metabolic syndrome (MetS-20% fructose), turmeric (80 mg/kg/day), and MetS + turmeric (80 mg/kg/day). Turmeric was administered orally for 60 days. Oxidative stress markers, lipid profiles, glucose levels, and histological changes were analyzed to assess the effects of turmeric supplementation.ResultsTurmeric supplementation significantly reduced body weight, systolic blood pressure, glucose levels, total cholesterol, low-density lipoprotein (LDL) cholesterol, and malondialdehyde (MDA) levels in MetS rats. Additionally, it increased high-density lipoprotein (HDL) cholesterol, vitamin C, vitamin A, vitamin E levels, catalase (CAT) activity, and superoxide dismutase (SOD) activity.ConclusionTurmeric supplementation at the administered dose demonstrated protective effects against the adverse impacts of a high-fructose diet in MetS development. These effects were attributed to enhanced antioxidant defense mechanisms, improved biochemical parameters, and reduced oxidative stress.
C1 [Ozturk, Kubra] Kirsehir Ahi Evran Univ, Fac Engn & Architecture, Dept Genet & Bioengn, Kirsehir, Turkiye.
   [Kocamuftuoglu, Gonca Ozan] Burdur Mehmet Akif Ersoy Univ, Fac Vet Med, Dept Vet Biochem, Burdur, Turkiye.
   [Karatepe, Mustafa] Firat Univ, Fac Arts & Sci, Dept Biochem, Elazig, Turkiye.
   [Kisacam, Mehmet Ali] Univ Hatay Mustafa Kemal, Fac Vet Med, Dept Vet Biochem, Antakya, Hatay, Turkiye.
   [Tektemur, Nalan Kaya; Ozan, Ibrahim Enver] Firat Univ, Fac Med, Dept Histol & Embryol, Elazig, Turkiye.
   [Onat, Elif] Adiyaman Univ, Fac Med, Dept Med Pharmacol, Adiyaman, Turkiye.
C3 Kirsehir Ahi Evran University; Mehmet Akif Ersoy University; Firat
   University; Firat University; Adiyaman University
RP Ozturk, K (corresponding author), Kirsehir Ahi Evran Univ, Fac Engn & Architecture, Dept Genet & Bioengn, Kirsehir, Turkiye.
EM kubraademirbag@gmail.com; gokocamuftuoglu@mehmetakif.edu.tr;
   mkaratepe23@yahoo.com; malikisacam065@hotmail.com;
   nalankaya@firat.edu.tr; drelifonat@gmail.com; eozan@firat.edu.tr
RI Ozturk, Kubra/KHE-3054-2024; KISAÇAM, Mehmet/AAE-7473-2019; Tektemur,
   Nalan/W-6712-2018; Karatepe, Mustafa/HII-5655-2022; onat,
   elif/Y-3938-2019
FU Coordinator of Scientific Research Projects at Fimath;rat University
   [VF.16.17]
FX This work was supported by the Coordinator of Scientific Research
   Projects [VF.16.17] at F & imath;rat University.
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NR 58
TC 0
Z9 0
U1 2
U2 2
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
EI 2316-7874
J9 NUTRIRE
JI Nutrire
PD FEB 3
PY 2025
VL 50
IS 1
AR 10
DI 10.1186/s41110-025-00316-8
PG 13
WC Food Science & Technology; Nutrition & Dietetics
WE Emerging Sources Citation Index (ESCI)
SC Food Science & Technology; Nutrition & Dietetics
GA U5C4V
UT WOS:001411971900001
DA 2025-06-11
ER

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AF Souto, Tayane dos Santos
   Nagamatsu Nakao, Fernanda Sayuri
   Giriko, Catherine Assuka
   Dias, Clarissa Tavares
   do Prado Cheberle, Ana Isabel
   Lambertucci, Rafael Herling
   Mendes-da-Silva, Cristiano
TI Lard-rich and canola oil-rich high-fat diets during pregnancy promote
   rats' offspring neurodevelopmental delay and behavioral disorders
SO PHYSIOLOGY & BEHAVIOR
LA English
DT Article
DE Maternal nutrition; Phenotypic plasticity; Reflex ontogeny; Anxiety;
   Depression; Aggressiveness
ID PITUITARY-ADRENAL AXIS; ANXIETY-LIKE BEHAVIOR; REFLEX ONTOGENY;
   INDUCED-OBESITY; INSULIN-RESISTANCE; AGGRESSIVE-BEHAVIOR;
   EXPERIMENTAL-MODELS; METABOLIC SYNDROME; NEONATAL TREATMENT; WEIGHT-GAIN
AB High-fat diets (HFDs) during pregnancy may damage the neural development and emotional behavior of rat offspring. Therefore, we investigated the neurobehavioral development of rat offspring who were fed a control diet (CD) or an HFD with lard (HFD-lard) or canola oil (HFD-canola oil), during pregnancy. Offspring's neurodevelopment (somatic growth, physical maturation, and ontogenesis reflex) was assessed while they were suckling. The rat's levels of depression, anxiety, and aggression were assessed through forced swimming, elevation plus a maze or open field test, and a foot-shock test on postnatal days 60, 80, and 110, respectively. Maternal HFDs with lard or canola oil promoted rats' offspring during suckling. They had reduced body weight and growth, physical maturation delay (auditory conduit and eyes opening to both groups HFDs-lard and canola oil; ear unfolding and incisor eruption only HFD-lard) and an ontogenesis reflex (palm grasp/vibrissa placing to both groups HFDs-lard and canola oil, and free-fall righting only in HFD-lard). Negative geotaxis resulted in the faster development of the HFD-lard offspring. Furthermore, in adulthood, the HDFs-offspring were more likely to be overweight, have shorter swimming times in the swim test, greater susceptibility to anxiety with an increased time spent in the closed arm in the elevated plus-maze while spending less time in the open arm, and having a decreased number of crossings and rearing in the open field. On the other hand, aggressive-like behavior was not affected. Therefore, these findings indicate that maternal HFDs enriched with lard or canola oil during pregnancy can impair the neurodevelopment of rat offspring and can perhaps be associated with possible changes to the emotional behavior of adult offspring.
C1 [Souto, Tayane dos Santos; Nagamatsu Nakao, Fernanda Sayuri; Giriko, Catherine Assuka; Dias, Clarissa Tavares; do Prado Cheberle, Ana Isabel; Lambertucci, Rafael Herling; Mendes-da-Silva, Cristiano] Fed Univ Sao Paulo UNIFESP, Lab Neurosci & Nutr, Dept Biosci, Campus Baixada Santista, BR-11060001 Santos, SP, Brazil.
   [Giriko, Catherine Assuka; Dias, Clarissa Tavares] UNIFESP, Hlth Sci, Campus Baixada Santista, BR-11060001 Santos, SP, Brazil.
C3 Universidade Federal de Sao Paulo (UNIFESP); Universidade Federal de Sao
   Paulo (UNIFESP)
RP Mendes-da-Silva, C (corresponding author), Univ Fed Sao Paulo UNIFESP, Dept Biociencias, Lab Neurociencia & Nutr LabNeuN, Campus Baixada Santista,Rua Silva Jardim 136, BR-11015020 Santos, SP, Brazil.
EM cristiano.mendes@unifesp.br
RI Lambertucci, Rafael/C-6975-2012; Cristiano Mendes-da-Silva,
   C./F-6656-2014
OI Tavares Dias, Clarissa/0000-0002-5184-7274
FU Fundacao de Amparo a Pesquisa do Estado de Sao Paulo [11/17577-3,
   11/17574-4]; Fundacao de Amparo a Pesquisa do Estado de Sao Paulo
   (FAPESP) [11/17577-3, 11/17574-4] Funding Source: FAPESP
FX The authors thank Mrs. Fabio Tadeu Montesano and Felipe Granado de Souza
   for technical assistance with the statistical analyses. We would like to
   thank Editage (www.editage.com) for English language editing. This
   research was supported by fellowships from Fundacao de Amparo a Pesquisa
   do Estado de Sao Paulo (FAPESP -processes 11/17577-3 and 11/17574-4).
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NR 92
TC 15
Z9 15
U1 0
U2 8
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0031-9384
EI 1873-507X
J9 PHYSIOL BEHAV
JI Physiol. Behav.
PD JAN 1
PY 2020
VL 213
AR 112722
DI 10.1016/j.physbeh.2019.112722
PG 11
WC Psychology, Biological; Behavioral Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Behavioral Sciences
GA LE6SG
UT WOS:000526852700016
PM 31676261
DA 2025-06-11
ER

PT J
AU Kovanen, L
   Donner, K
   Kaunisto, M
   Partonen, T
AF Kovanen, Leena
   Donner, Kati
   Kaunisto, Mari
   Partonen, Timo
TI CRY1, CRY2 and PRKCDBP genetic variants in
   metabolic syndrome
SO HYPERTENSION RESEARCH
LA English
DT Article
DE cryptochrome; diurnal; genotype; hypertension; population
ID CIRCADIAN CLOCK; LARGE-SCALE; ASSOCIATION; DEPRESSION; EXPRESSION; MICE;
   SUSCEPTIBILITY; HYPERTENSION; DISRUPTION; REPRESSION
AB The circadian clock affects metabolic cycles, and there is a link between circadian clock genes and metabolic syndrome. Therefore, we wanted to investigate whether variants of the core circadian clock genes, cryptochrome circadian clocks 1 and 2 (CRY1 and CRY2), or those of protein kinase C, delta binding protein (PRKCDBP), which regulate the interactions and abundance of dimers of the period and cryptochrome proteins, are associated with metabolic syndrome or its components. The association of 48 single-nucleotide polymorphisms (SNPs) from CRY1, CRY2 and PRKCDBP genes with metabolic disorder or its components was analyzed in a sample of 5910 individuals. Genotyping was performed using the Sequenom MassARRAY system. SNPs and haplotypes were analyzed using linear or logistic regression with additive models controlling for age and sex. Continuous phenotypes were permuted 10 000 times. False discovery rate q-values were calculated to correct for multiple testing. Overall, CRY1 and CRY2 variants showed nominal association with the metabolic syndrome components, hypertension and triglyceride levels, and one CRY2 variant had an association with metabolic syndrome, although none of these associations yielded significant q-values. However, the haplotype analysis of these variants supported the association of CRY1 with arterial hypertension and elevated blood pressure. Further studies are warranted regarding the role of CRY1 in cardiovascular diseases.
C1 [Kovanen, Leena; Partonen, Timo] Natl Inst Hlth & Welf THL, Dept Mental Hlth & Substance Abuse Serv, FI-00271 Helsinki, Finland.
   [Donner, Kati; Kaunisto, Mari] Univ Helsinki, Inst Mol Med Finland FIMM, Helsinki, Finland.
   [Kaunisto, Mari] Folkhalsan Res Ctr, Folkhalsan Inst Genet, Helsinki, Finland.
C3 Finland National Institute for Health & Welfare; University of Helsinki;
   Folkhalsan Research Center
RP Kovanen, L (corresponding author), Natl Inst Hlth & Welf THL, Dept Mental Hlth & Substance Abuse Serv, POB 30, FI-00271 Helsinki, Finland.
EM leena.kovanen@thl.fi
RI Kaunisto, Mari/IUP-3784-2023; Donner, Kati/HJI-0750-2023; Partonen,
   Timo/G-1105-2012
OI Partonen, Timo/0000-0003-1951-2455; Kaunisto, Mari/0000-0002-6946-9195;
   Kovanen, Leena/0000-0002-3552-124X; Donner, Kati/0000-0001-9190-4336
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NR 52
TC 30
Z9 33
U1 0
U2 9
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0916-9636
EI 1348-4214
J9 HYPERTENS RES
JI Hypertens. Res.
PD MAR
PY 2015
VL 38
IS 3
BP 186
EP 192
DI 10.1038/hr.2014.157
PG 7
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA CD0AU
UT WOS:000350733300003
PM 25391456
OA Bronze
DA 2025-06-11
ER

PT J
AU Moya-Lacasa, C
   González-Blanco, L
   Couce-Sánchez, M
   Martínez-Cao, C
   Paniagua, G
   Zurrón-Madera, P
   Arranz, B
   Safont, G
   Sierra, P
   García-Portilla, MP
AF Moya-Lacasa, Carlota
   Gonzalez-Blanco, Leticia
   Couce-Sanchez, Manuel
   Martinez-Cao, Clara
   Paniagua, Gonzalo
   Zurron-Madera, Paula
   Arranz, Belen
   Safont, Gemma
   Sierra, Pilar
   Garcia-Portilla, Maria Paz
TI Impact of sleep on clinical outcomes in a cohort of patients with
   bipolar disorder
SO EUROPEAN JOURNAL OF PSYCHIATRY
LA English
DT Article
DE Bipolar disorder; Sleep; Functionality; Anxiety
ID COGNITIVE IMPAIRMENT; SPANISH VERSION; DISTURBED SLEEP; DEPRESSION;
   SYMPTOMS; QUALITY; SCALE; MANIA; LIFE
AB Background and Objectives: Sleep disturbances are part of the diagnostic criteria for bipolar disorder (BD). They are prodromal symptoms of the disorder and are present during relapse and euthymia. We aimed to identify the impact of sleep, as an endophenotype, on BD patients in terms of clinical features including suicidality, severity of the disorder, somatic comorbidities, and functionality. Methods: This is a secondary analysis of a cross-sectional study including 291 outpatients during follow-up at four sites in Spain. The score on the sleep domain of the Hamilton Depression Rating Scale (HDRS_sleep) was used to evaluate current sleep disturbances. Other psychometric tests, such as the Young Mania Rating Scale or the Hamilton Anxiety Rating Scale, were used to assess clinical status. Sociodemographic and other clinical variables were collected. Statistical analysis was performed using IBM SPSS Statistics, Version 27.0. Non-parametric tests and multiple linear regression were used. Results: Of the 291 patients included in the study, 64.3 % ( n = 187) were women. Mean age was 47.86 (SD=12.693). The sample was segmented into two groups: euthymia and non-euthymia, and the analysis was carried out separately in each. We observed no differences in either of these groups in HDRS_sleep with regard to sex, age, metabolic syndrome, coffee intake, or smoking. After adjusting for covariates, anxiety and functionality were signi ficantly related to sleep in the non-euthymia group. Conclusions: Sleep disturbances are frequent in BD, even during euthymia. Its impact on functionality and anxiety levels highlights the importance of targeting sleep in clinical practice to improve the outcome of the disorder. (c) 2024 The Authors. Published by Elsevier Espa & ntilde;a, S.L.U. on behalf of Sociedad Espa & ntilde;ola de Psiquiatr & iacute;a y Salud Mental. This is an open access article under the CC BY license (http:// creativecommons.org/licenses/by/4.0/).
C1 [Moya-Lacasa, Carlota; Gonzalez-Blanco, Leticia; Martinez-Cao, Clara; Paniagua, Gonzalo; Zurron-Madera, Paula; Garcia-Portilla, Maria Paz] Univ Oviedo, Dept Psychiat, Av Julian Claveria 6, Oviedo 33006, Spain.
   [Moya-Lacasa, Carlota; Gonzalez-Blanco, Leticia; Couce-Sanchez, Manuel; Paniagua, Gonzalo; Zurron-Madera, Paula; Garcia-Portilla, Maria Paz] Serv Salud Principado Asturias, Psychiat, Oviedo, Spain.
   [Gonzalez-Blanco, Leticia; Garcia-Portilla, Maria Paz] Inst Invest Sanit Principado Asturias, Psychiat, Oviedo, Spain.
   [Moya-Lacasa, Carlota; Gonzalez-Blanco, Leticia; Martinez-Cao, Clara; Paniagua, Gonzalo; Garcia-Portilla, Maria Paz] Inst Neurociencias Principado Asturias, Psychiat, Oviedo, Spain.
   [Gonzalez-Blanco, Leticia; Arranz, Belen; Safont, Gemma; Garcia-Portilla, Maria Paz] Ctr Invest Biomed Red Salud Mental CIBERSAM, Psychiat, Madrid, Spain.
   [Arranz, Belen] Parc Sanit St Joan Deu, Barcelona, Spain.
   [Safont, Gemma] Univ Barcelona, Hosp Univ Mutua Terrassa, Dept Psychiat, Barcelona, Spain.
   [Sierra, Pilar] Univ & Polytech Hosp La Fe, Dept Psychiat & Clin Psychol, Valencia, Spain.
   [Sierra, Pilar] Univ Valencia, Dept Med, Valencia, Spain.
   [Gonzalez-Blanco, Leticia] Univ Oviedo, CIBERSAM, Av Julian Claveria 6, Oviedo 33006, Spain.
C3 University of Oviedo; Instituto de Investigacion Sanitaria del
   Principado de Asturias (ISPA); CIBER - Centro de Investigacion Biomedica
   en Red; CIBERSAM; Hospital Universitario Mutua Terrassa; University of
   Barcelona; University of Valencia; CIBER - Centro de Investigacion
   Biomedica en Red; CIBERSAM; University of Oviedo
RP González-Blanco, L (corresponding author), Univ Oviedo, Dept Psychiat, Av Julian Claveria 6, Oviedo 33006, Spain.; González-Blanco, L (corresponding author), Univ Oviedo, CIBERSAM, Av Julian Claveria 6, Oviedo 33006, Spain.
RI Couce-Sánchez, Manuel/ITU-9828-2023; Gonzalez-Blanco,
   Leticia/HIU-0255-2022; Garcia-Portilla, Paz/AAC-8272-2020
OI Moya Lacasa, Carlota/0000-0002-5911-5991; Zurron-Madera,
   Paula/0000-0002-5469-9262; Couce-Sanchez, Manuel/0000-0002-2183-3824;
   Garcia-Portilla, Paz/0000-0003-3643-1622
FU Instituto de Salud Carlos III (ISCIII) [PI11/02493]
FX This study was supported by a grant from the Instituto de Salud Carlos
   III (ISCIII, grant number PI11/02493) .
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NR 43
TC 0
Z9 0
U1 1
U2 3
PU ELSEVIER ESPANA SLU
PI BARCELONA
PA AV JOSEP TARRADELLAS, 20-30, 1ERA PLANTA, BARCELONA, CP-08029, SPAIN
SN 0213-6163
J9 EUR J PSYCHIAT
JI Eur. J. Psychiat.
PD OCT-DEC
PY 2024
VL 38
IS 4
AR 100264
DI 10.1016/j.ejpsy.2024.100264
EA JUL 2024
PG 8
WC Psychiatry
WE Social Science Citation Index (SSCI)
SC Psychiatry
GA YF2W1
UT WOS:001267015300001
OA hybrid
DA 2025-06-11
ER

PT J
AU Green, JE
   Davis, JA
   Berk, M
   Hair, C
   Loughman, A
   Castle, D
   Athan, E
   Nierenberg, AA
   Cryan, JF
   Jacka, F
   Marx, W
AF Green, Jessica Emily
   Davis, Jessica A.
   Berk, Michael
   Hair, Christopher
   Loughman, Amy
   Castle, David
   Athan, Eugene
   Nierenberg, Andrew A.
   Cryan, John F.
   Jacka, Felice
   Marx, Wolfgang
TI Efficacy and safety of fecal microbiota transplantation for the
   treatment of diseases other than Clostridium difficile infection:
   a systematic review and meta-analysis
SO GUT MICROBES
LA English
DT Review
DE Fecal microbiota transplantation clostridium difficile; microbiome;
   meta-analysis; RCT; systematic review; ulcerative colitis; irritable
   bowel syndrome; psychiatry; mental disorder; neuroscience; depression
ID INFLAMMATORY-BOWEL-DISEASE; ACTIVE ULCERATIVE-COLITIS; INTESTINAL
   MICROBIOTA; GUT MICROBIOME; INSULIN SENSITIVITY; METABOLIC SYNDROME;
   REMISSION; THERAPY; BACTERIOTHERAPY; PLACEBO
AB The intestinal microbiome has been identified as a key modifier for a variety of health conditions. Fecal Microbiota Transplantation (FMT) has emerged as a fast, safe, and effective means by which to modify the intestinal microbiome and potentially treat a variety of health conditions. Despite extensive research of FMT for CDI, there is a lack of clarity informed by systematic synthesis of data regarding the safety and efficacy of FMT for other health conditions. This systematic review used PRISMA guidelines and was prospectively registered with PROSPERO (CRD42018104243). In March 2020, a search of MEDLINE, EMBASE, and PsycINFO was conducted. We identified 26 eligible studies. A meta-analysis of FMT for active Ulcerative Colitis (UC) showed that FMT significantly improved rates of clinical remission (OR = 3.634, 95% CI = 1.940 to 6.808, I-2 = 0%, p < .001), clinical response (OR = 2.634, 95% CI = 1.441 to 4.815, I-2 = 33%, p = .002) and endoscopic remission (OR = 4.431, 95% CI = 1.901 to 10.324, I-2 = 0%, p = .001). With respect to Irritable Bowel Syndrome, a meta-analysis showed no significant change in symptoms following FMT (p = .739). Hepatic disorders, metabolic syndrome, and antibiotic-resistant organisms were conditions with emerging data on FMT. Serious adverse events (AE) were more often reported in control group participants (n = 43) compared with FMT group participants (n = 26). There were similar rates of mild to moderate AE in both groups. Preliminary data suggest that FMT is a potentially safe, well-tolerated and efficacious treatment for certain conditions other than CDI, with evidence for active UC being the most compelling.
C1 [Green, Jessica Emily; Davis, Jessica A.; Berk, Michael; Loughman, Amy; Athan, Eugene; Jacka, Felice; Marx, Wolfgang] Deakin Univ, Inst Mental & Phys Hlth & Clin Translat, Food & Mood Ctr, IMPACT,Sch Med,Barwon Hlth, Geelong, Vic, Australia.
   [Green, Jessica Emily] Monash Univ, Fac Med Nursing & Hlth Sci, Cent Clin Sch, Monash Alfred Psychiat Res Ctr Maprc, Melbourne, Vic, Australia.
   [Green, Jessica Emily] Peninsula Hlth, Dept Psychiat, Frankston, Australia.
   [Berk, Michael; Castle, David] Univ Melbourne, Dept Psychiat, Parkville, Vic, Australia.
   [Berk, Michael] Orygen Youth Hlth Res Ctr, Melbourne, Vic, Australia.
   [Berk, Michael] Ctr Youth Mental Hlth, Melbourne, Vic, Australia.
   [Berk, Michael; Hair, Christopher; Athan, Eugene] Florey Inst Neurosci & Mental Hlth, Parkville, Vic, Australia.
   [Berk, Michael; Hair, Christopher; Athan, Eugene] Barwon Hlth, Geelong, Vic, Australia.
   [Castle, David] St Vincents Hlth, Dept Psychiat, East Melbourne, Vic, Australia.
   [Athan, Eugene] Deakin Univ, Sch Med, Geelong, Vic, Australia.
   [Nierenberg, Andrew A.] Dauten Family Ctr Bipolar Treatment Innovat, Dept Psychiat, Boston, MA USA.
   [Nierenberg, Andrew A.] Harvard Med Sch, Boston, MA 02115 USA.
   [Cryan, John F.] Univ Coll Cork, Dept Anat & Neurosci, Cork, Ireland.
   [Cryan, John F.] APC Microbiome, Cork, Ireland.
   [Jacka, Felice] Royal Childrens Hosp, Murdoch Childrens Res Inst, Ctr Adolescent Hlth, Parkville, Vic, Australia.
   [Jacka, Felice] Black Dog Inst, Melbourne, Vic, Australia.
   [Jacka, Felice] James Cook Univ, Townsville, Qld, Australia.
C3 Deakin University; Barwon Health; Monash University; University of
   Melbourne; Orygen, The National Centre of Excellence in Youth Mental
   Health; Orygen, The National Centre of Excellence in Youth Mental
   Health; Florey Institute of Neuroscience & Mental Health; Barwon Health;
   Deakin University; Harvard University; Harvard Medical School;
   University College Cork; Royal Children's Hospital Melbourne; Murdoch
   Children's Research Institute; Black Dog Institute; James Cook
   University
RP Green, JE (corresponding author), Deakin Univ, Inst Mental & Phys Hlth & Clin Translat, Food & Mood Ctr, IMPACT,Sch Med,Barwon Hlth, Geelong, Vic, Australia.
EM jessica.emily.green1@gmail.com
RI Berk, Michael/AGH-9427-2022; Nierenberg, ANierenberg/IAR-5549-2023;
   Jacka, Felice/ABE-6322-2020; Cryan, John/A-6950-2013; Marx,
   Wolfgang/AFO-7355-2022; Berk, Michael/M-7891-2013; Loughman,
   Amy/J-9295-2018; Jacka, Felice/D-9424-2012
OI Berk, Michael/0000-0002-5554-6946; Cryan, John/0000-0001-5887-2723;
   Loughman, Amy/0000-0002-0257-1443; Marx, Wolfgang/0000-0002-8556-8230;
   Jacka, Felice/0000-0002-9825-0328; Davis, Jessica/0000-0001-7246-4291;
   Castle, David/0000-0002-3075-1580
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NR 71
TC 102
Z9 106
U1 1
U2 31
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1949-0976
EI 1949-0984
J9 GUT MICROBES
JI Gut Microbes
PD NOV 9
PY 2020
VL 12
IS 1
BP 1
EP 25
DI 10.1080/19490976.2020.1854640
PG 25
WC Gastroenterology & Hepatology; Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Gastroenterology & Hepatology; Microbiology
GA PH5KZ
UT WOS:000600452600001
PM 33345703
OA gold, Green Accepted, Green Published
DA 2025-06-11
ER

PT J
AU Petek, TH
   Homsak, E
   Svetej, M
   Varda, NM
AF Petek, Tjasa Hertis
   Homsak, Evgenija
   Svetej, Mateja
   Varda, Natasa Marcun
TI Metabolic Syndrome, Inflammation, Oxidative Stress, and Vitamin D Levels
   in Children and Adolescents with Obesity
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE children; inflammation; oxidative stress; metabolic syndrome; obesity;
   vitamin D; visceral fat thickness; I-TAC/CXCL11; mediation analysis
ID BIOMARKERS; TRIALS; RISK
AB Metabolic syndrome (MetS) is associated with systemic inflammation, oxidative stress, and hypovitaminosis D. Our aim was to determine whether vitamin D mediates inflammation and oxidative stress, assessed through selected biomarkers, in children with obesity and/or MetS. Eighty children with normal weight, overweight, or obesity were analyzed for serum vitamin D, C-reactive protein, leukocytes, adiponectin, monocyte chemoattractant protein-1, myeloperoxidase, interferon-inducible T-cell alpha chemoattractant (I-TAC/CXCL11), superoxide dismutase-1, fasting lipid and glucose levels, ultrasound-measured abdominal fat thickness, waist circumference, body mass index and blood pressure. Children with obesity or overweight had lower vitamin D levels, increased blood pressure, visceral and subcutaneous fat thickness, and higher leukocytes, C-reactive protein, and myeloperoxidase levels. Those with MetS also had lower adiponectin levels. Vitamin D levels are negatively correlated with body mass index, waist circumference, and visceral and subcutaneous fat thickness. Correlation, mediation, and regression analyses showed no link between vitamin D and inflammatory/oxidative stress variables. The novel biomarker I-TAC did not correlate with obesity or vitamin D status. Our results indicate that vitamin D does not significantly mediate inflammation or oxidative stress in children and adolescents with obesity and/or MetS. Selected inflammation/oxidative stress biomarkers appear to be altered primarily due to obesity rather than vitamin D status.
C1 [Petek, Tjasa Hertis; Varda, Natasa Marcun] Univ Med Ctr Maribor, Dept Pediat, Ljubljanska Ulica 5, Maribor 2000, Slovenia.
   [Homsak, Evgenija; Svetej, Mateja] Univ Med Ctr Maribor, Dept Lab Diagnost, Ljubljanska Ulica 5, Maribor 2000, Slovenia.
   [Varda, Natasa Marcun] Univ Maribor, Fac Med, Taborska Ulica 8, Maribor 2000, Slovenia.
C3 University of Maribor; University of Maribor; University of Maribor
RP Varda, NM (corresponding author), Univ Med Ctr Maribor, Dept Pediat, Ljubljanska Ulica 5, Maribor 2000, Slovenia.; Varda, NM (corresponding author), Univ Maribor, Fac Med, Taborska Ulica 8, Maribor 2000, Slovenia.
EM tjasa.hertispetek@ukc-mb.si; evgenija.homsak@ukc-mb.si;
   mateja.svetej@ukc-mb.si; natasa.marcunvarda@ukc-mb.si
OI Marcun Varda, Natasa/0000-0003-0634-3576; Homsak,
   Evgenija/0000-0003-3904-1814
FU University Medical Center Maribor;  [IRP-2023/01-10]
FX This research was funded by the University Medical Center Maribor
   (IRP-2023/01-10).
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NR 55
TC 3
Z9 3
U1 1
U2 1
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD OCT
PY 2024
VL 25
IS 19
AR 10599
DI 10.3390/ijms251910599
PG 17
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA I7Z5X
UT WOS:001332403600001
PM 39408928
OA gold
DA 2025-06-11
ER

PT J
AU Haufe, S
   Kerling, A
   Protte, G
   Bayerle, P
   Stenner, HT
   Rolff, S
   Sundermeier, T
   Kück, M
   Ensslen, R
   Nachbar, L
   Lauenstein, D
   Böthig, D
   Bara, C
   Hanke, AA
   Terkamp, C
   Stiesch, M
   Hilfiker-Kleiner, D
   Haverich, A
   Tegtbur, U
AF Haufe, Sven
   Kerling, Arno
   Protte, Gudrun
   Bayerle, Pauline
   Stenner, Hedwig T.
   Rolff, Simone
   Sundermeier, Thorben
   Kueck, Momme
   Ensslen, Ralf
   Nachbar, Lars
   Lauenstein, Dirk
   Boethig, Dietmar
   Bara, Christoph
   Hanke, Alexander A.
   Terkamp, Christoph
   Stiesch, Meike
   Hilfiker-Kleiner, Denise
   Haverich, Axel
   Tegtbur, Uwe
TI Telemonitoring-supported exercise training, metabolic syndrome severity,
   and work ability in company employees: a randomised controlled trial
SO LANCET PUBLIC HEALTH
LA English
DT Article
ID PHYSICAL-ACTIVITY; WORKPLACE; ASSOCIATION; HEALTH; INTERVENTION;
   METAANALYSIS; POPULATION; PREVALENCE; DISABILITY; FITNESS
AB Background Metabolic syndrome is a predisposing factor for cardiovascular and metabolic disease, but also has socioeconomic relevance by affecting the health and productivity of workers. We tested the effect of regular telemonitoring-supported physical activity on metabolic syndrome severity and work ability in company employees.
   Methods This was a prospective, randomised, parallel-group, and assessor-blind study done in workers in the main Volkswagen factory (Wolfsburg, Germany). Volunteers with diagnosed metabolic syndrome according to American Heart Association/National Heart, Lung, and Blood Institute criteria were randomly assigned (1: 1) to a 6-month lifestyle intervention focusing on regular exercise (exercise group), or to a waiting-list control group, using a computer-based assignment list with variable block length. Participants in the exercise group received individual recommendations for exercise at face-to-face meetings and via a smartphone application, with the aim of doing 150 min physical activity per week. Activities were supervised and adapted using activity-monitor data, which were transferred to a central database. Participants in the control group continued their current lifestyle and were informed about the possibility to receive the supervised intervention after study completion. The primary outcome was the change in metabolic syndrome severity (metabolic syndrome Z score) after 6 months in the intention-to treat population. This trial is registered with ClinicalTrials.gov, number NCT03293264, and is closed to new participants.
   Findings 543 individuals were screened between Oct 10, 2017, and Feb 27, 2018, of whom 314 (mean age 48 years [SD 8]) were randomly assigned to receive the intervention (n=160; exercise group) or to a waiting list (n=154; control group). The mean metabolic syndrome Z score for the exercise group was significantly reduced after the 6-month intervention period (0.93 [SD 0.63] before and 0.63 [0.64] after the intervention) compared with the control group (0.95 [0.55] and 0.90 [0.61]; difference between groups -0.26 [95% CI -0.35 to -0.16], p<0.0001). We documented 11 adverse events in the exercise group, with only one event (a twisted ankle) regarded as directly caused by the intervention.
   Interpretation A 6-month exercise-focused intervention using telemonitoring systems reduced metabolic syndrome severity. This form of intervention shows significant potential to reduce disease risk, while also improving mental health, work ability, and productivity-related outcomes for employees at high risk for cardiovascular and metabolic disease.
   Funding Audi BKK health insurance and the German Research Foundation through the Cluster of Excellence REBIRTH. Copyright (c) 2019 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY-NC-ND 4.0 license.
C1 [Haufe, Sven; Kerling, Arno; Protte, Gudrun; Bayerle, Pauline; Stenner, Hedwig T.; Rolff, Simone; Sundermeier, Thorben; Kueck, Momme; Hanke, Alexander A.; Tegtbur, Uwe] Hannover Med Sch, Inst Sports Med, D-30625 Hannover, Germany.
   [Boethig, Dietmar; Bara, Christoph; Haverich, Axel] Hannover Med Sch, Dept Cardiac Thorac Transplantat & Vasc Surg, Hannover, Germany.
   [Terkamp, Christoph] Hannover Med Sch, Dept Gastroenterol Hepatol & Endocrinol, Hannover, Germany.
   [Stiesch, Meike] Hannover Med Sch, Dept Prosthet Dent & Biomed Mat Sci, Hannover, Germany.
   [Hilfiker-Kleiner, Denise] Hannover Med Sch, Dept Cardiol & Angiol, Hannover, Germany.
   [Ensslen, Ralf; Nachbar, Lars] Volkswagen AG, Wolfsburg, Germany.
   [Lauenstein, Dirk] Audi BKK Hlth Insurance, Ingolstadt, Germany.
C3 Hannover Medical School; Hannover Medical School; Hannover Medical
   School; Hannover Medical School; Hannover Medical School; Volkswagen;
   Volkswagen Germany
RP Haufe, S (corresponding author), Hannover Med Sch, Inst Sports Med, D-30625 Hannover, Germany.
EM haufe.sven@mh-hannover.de
RI Stiesch, Meike/GRX-4992-2022; Haverich, Axel/AAC-7552-2022; Haufe,
   Sven/G-1944-2011
OI Boeck, Hedwig Theda/0000-0001-9588-4336; Haufe, Sven/0000-0002-5259-4352
FU German Research Foundation through the Cluster of Excellence REBIRTH;
   Audi BKK health insurance
FX Audi BKK health insurance and the German Research Foundation through the
   Cluster of Excellence REBIRTH.
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NR 31
TC 39
Z9 41
U1 0
U2 22
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 2468-2667
J9 LANCET PUBLIC HEALTH
JI Lancet Public Health
PD JUL
PY 2019
VL 4
IS 7
BP E343
EP E352
DI 10.1016/S2468-2667(19)30075-1
PG 10
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA IG5AH
UT WOS:000473815300014
PM 31204284
OA gold
DA 2025-06-11
ER

PT J
AU Dortland, AKBV
   Giltay, EJ
   van Veen, T
   van Pelt, J
   Zitman, FG
   Penninx, BWJH
AF Dortland, Arianne K. B. van Reedt
   Giltay, Erik J.
   van Veen, Tineke
   van Pelt, Johannes
   Zitman, Frans G.
   Penninx, Brenda W. J. H.
TI Associations Between Serum Lipids and Major Depressive Disorder: Results
   From the Netherlands Study of Depression and Anxiety (NESDA)
SO JOURNAL OF CLINICAL PSYCHIATRY
LA English
DT Article
ID UNHEALTHY LIFE-STYLES; LIPOPROTEIN CONCENTRATIONS; CHOLESTEROL
   REDUCTION; METABOLIC SYNDROME; SYMPTOMS; OBESITY; MEN; ABSORPTION;
   MORTALITY; THERAPY
AB Background: Several studies have suggested an association between lipids or lipoproteins and depression, but findings are contradictory. However, previous studies did not always take into consideration potentially mediating factors or heterogeneity of symptoms, which may clarify contradicting findings.
   Method: We compared levels of serum total, low-density lipoprotein (LDL), and high-density lipoprotein (HDL) cholesterol and triglyceride between 761 subjects with current major depressive disorder (MDD) (Composite International Diagnostic Interview, based on the DSM-IV), 1,071 subjects with remitted MDD, and 629 controls, aged 18 to 65 years. Subjects participated in the baseline assessment of the Netherlands Study of Depression and Anxiety, which lasted from September 2004 to February 2007. We studied the impact of adjustment for sociodemographics, lifestyle-related covariates, and antidepressant use and examined the association between specific psychopathological characteristics and lipid/lipoprotein levels.
   Results: HDL cholesterol level was lower (P=.007) and triglyceride level was higher (P=.001) in current MDD versus remitted MDD and controls. After adjustment for level of education, body mass index (BMI), smoking status, and alcohol use, dissimilarities lost statistical significance. Depression severity, comorbid dysthymia, and melancholic and atypical features were all associated with lipids/lipoproteins, but most associations attenuated after adjustment for covariates, especially BMI. The association between melancholic features and lower HDL cholesterol (P=.038) and between atypical depression and higher total and LDL cholesterol (P=.004 and P=.002, respectively) persisted after full adjustment.
   Conclusions: Adverse lipoprotein patterns were found in patients with MDD. The fact that these associations diminished after adjustment for lifestyle-related factors, especially BMI, suggests that the unfavorable lipid/lipoprotein pattern among depressed subjects is mainly secondary to lifestyle-related factors. However, melancholic features were independently associated with lower HDL cholesterol, and atypical depression was independently associated with higher total and LDL cholesterol. J Clin Psychiatry 2010;71(6):729-736 (C) Copyright 2009 Physicians Postgraduate Press, Inc.
C1 [Dortland, Arianne K. B. van Reedt; Giltay, Erik J.; van Veen, Tineke; Zitman, Frans G.; Penninx, Brenda W. J. H.] Leiden Univ, Med Ctr, Dept Psychiat, NL-2300 RC Leiden, Netherlands.
   [van Pelt, Johannes] Leiden Univ, Med Ctr, Dept Clin Chem, NL-2300 RC Leiden, Netherlands.
   [Penninx, Brenda W. J. H.] Vrije Univ Amsterdam, Med Ctr, Dept Psychiat, Amsterdam, Netherlands.
   [Penninx, Brenda W. J. H.] Univ Groningen, Univ Med Ctr Groningen, Dept Psychiat, Groningen, Netherlands.
C3 Leiden University; Leiden University Medical Center (LUMC); Leiden
   University - Excl LUMC; Leiden University; Leiden University Medical
   Center (LUMC); Leiden University - Excl LUMC; Vrije Universiteit
   Amsterdam; University of Groningen
RP Dortland, AKBV (corresponding author), Leiden Univ, Med Ctr, Dept Psychiat, POB 9600, NL-2300 RC Leiden, Netherlands.
EM akbvanreedtdortland@lumc.nl
RI Penninx, Brenda/S-7627-2017; Giltay, Erik/AAL-9948-2021; Zitman,
   Frans/E-7705-2010
OI Giltay, Erik J./0000-0001-8874-2292
FU Dutch Scientific Organization (ZON-MW) [10-000-1002]; VU University
   Medical Center,; GGZ Buitenamstel; GGZ Geestgronden; Leiden University
   Medical Center; GGZ Rivierduinen; University Medical Center Groningen,
   Lentis; GGZ Friesland; GGZ Drenthe; Netherlands Organisation for
   Scientific Research [917.66.320]
FX The infrastructure for the Netherlands Study of Depression and Anxiety
   is funded through the Geestkracht program of the Dutch Scientific
   Organization (ZON-MW, grant number 10-000-1002) and matching funds from
   participating universities and mental health care organizations (VU
   University Medical Center, GGZ Buitenamstel, GGZ Geestgronden, Leiden
   University Medical Center, GGZ Rivierduinen, University Medical Center
   Groningen, Lentis, GGZ Friesland, GGZ Drenthe).Data analyses were
   supported by Netherlands Organisation for Scientific Research grant
   (Vidi, 917.66.320) to Dr Penninx.
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NR 46
TC 102
Z9 104
U1 1
U2 18
PU PHYSICIANS POSTGRADUATE PRESS
PI MEMPHIS
PA P O BOX 752870, MEMPHIS, TN 38175-2870 USA
SN 0160-6689
EI 1555-2101
J9 J CLIN PSYCHIAT
JI J. Clin. Psychiatry
PD JUN
PY 2010
VL 71
IS 6
BP 729
EP 736
DI 10.4088/JCP.08m04865blu
PG 8
WC Psychology, Clinical; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA 612DN
UT WOS:000278877100008
PM 20021996
DA 2025-06-11
ER

PT J
AU Ragy, MM
   Ahmed, SM
AF Ragy, Merhan Mamdouh
   Ahmed, Sabreen Mahmoud
TI Protective effects of either C-peptide or l-arginine on pancreatic -cell
   function, proliferation, and oxidative stress in streptozotocin-induced
   diabetic rats
SO JOURNAL OF CELLULAR PHYSIOLOGY
LA English
DT Article
DE apoptosis; cardiometabolic risk factor; C-peptide; diabetes; nitric
   oxide
ID INSULIN-RESISTANCE; ADIPOSE-TISSUE; STEM-CELLS; SUPPLEMENTATION;
   APOPTOSIS; GLUCOSE; HYPERGLYCEMIA; NEPHROPATHY; PATHWAYS; GROWTH
AB Diabetes and cardiometabolic risk factors including hypertension and dyslipidemia are the major threats to human health in the 21st century. Apoptosis in pancreatic tissue is one of the major causes of diabetes type 1 progression. The aim of this study was to investigate the effects of C-peptide or l-arginine on some cardiometabolic risk factors, pancreatic morphology, function and apoptosis, and the mechanisms of their actions. Forty adult male albino rats were divided into four equal groups: 1control nondiabetic, 2diabetic (no treatment), 3diabetic+C-peptide, and 4diabetic+ l-arginine. Diabetes was induced by a single intraperitoneal injection of high dose streptozotocin. At the end of the experiment, sera glucose, insulin levels, total antioxidant capacity (TAC), malondialdehyde (MDA), nitric oxide (NO), and pancreatic MDA, TAC, and B-cell lymphoma 2 were measured. The morphology and proliferating activity of the pancreas were examined by hematoxylin and eosin histological stain, proliferative cell nuclear antigen (PCNA), and insulin antibodies. Our results showed that induction of diabetes caused hyperglycemia, dyslipidemia, and oxidative stress. However, administration of C-peptide or l-arginine significantly improved the pancreatic histopathology with a significant increase in the area % of insulin immunoreactivity, the number of PCNA immunopositive cells, the number of islets, and the diameter of islets compared with the diabetic group. C-peptide treatment of the diabetic rats completely corrected these errors, while l-arginine partially antagonized the above diabetic complications. So the administration of C-peptide as an adjuvant therapy in type 1 diabetes can significantly decrease apoptosis of pancreas and subsequent progression of diabetes complication.
C1 [Ragy, Merhan Mamdouh] Menia Univ, Dept Physiol, Fac Med, Al Minya 61111, Egypt.
   [Ahmed, Sabreen Mahmoud] Menia Univ, Dept Anat, Fac Med, Al Minya, Egypt.
C3 Egyptian Knowledge Bank (EKB); Minia University; Egyptian Knowledge Bank
   (EKB); Minia University
RP Ragy, MM (corresponding author), Menia Univ, Dept Physiol, Fac Med, Al Minya 61111, Egypt.
EM merhanel@yahoo.com
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NR 49
TC 20
Z9 21
U1 0
U2 44
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0021-9541
EI 1097-4652
J9 J CELL PHYSIOL
JI J. Cell. Physiol.
PD JUL
PY 2019
VL 234
IS 7
BP 11500
EP 11510
DI 10.1002/jcp.27808
PG 11
WC Cell Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Physiology
GA HQ8AL
UT WOS:000462645700146
PM 30515793
DA 2025-06-11
ER

PT J
AU Torun, AN
   Vural, M
   Cece, H
   Camuzcuoglu, H
   Toy, H
   Aksoy, N
AF Torun, Ayse Nur
   Vural, Mehmet
   Cece, Hasan
   Camuzcuoglu, Hakan
   Toy, Harun
   Aksoy, Nurten
TI Paraoxonase-1 is not affected in polycystic ovary syndrome without
   metabolic syndrome and insulin resistance, but oxidative stress is
   altered
SO GYNECOLOGICAL ENDOCRINOLOGY
LA English
DT Article
DE Polycystic ovary syndrome (PCOS); metabolic syndrome (MetS); total
   antioxidant status (TAS); oxidative stress; paraoxonase (PON)
ID LOW-DENSITY-LIPOPROTEIN; C-REACTIVE PROTEIN; CHRONIC INFLAMMATION;
   CARDIOVASCULAR RISK; AUTOMATED-METHOD; WOMEN; DISEASE; POLYMORPHISM;
   CONTRIBUTE; INDEXES
AB Paraoxonase-1 (PON1) activity is decreased in polycystic ovary syndrome (PCOS) having metabolic syndrome (MetS) or insulin resistance (IR). We aimed to assess PON1 activity and oxidative stress in PCOS without MetS or IR. Metabolic and hormonal parameters, high-sensitive C-reactive protein (hs-CRP), oxidative stress parameters (total antioxidant status (TAS), total oxidative stress (TOS), oxidative stress index (OSI), lipid hydroperoxide (LOOH), total free sulfhydryl (-SH) groups), PON and arylesterase were analyzed in 30 normal weighed patients with PCOS without MetS or IR and 20 normal controls. Hs-CRP, PON, arylesterase, and TAS levels of PCOS and control groups were similar. LOOH, TOS, and OSI of PCOS group were higher than in the controls (p < 0.05; p < 0.001, and p < 0.001, respectively). -SH group levels showed a positive correlation with free testosterone (fT). TOS positively correlated with free androgen index (FAI), body mass index (BMI), waist-to-hip ratio (WHR), LOOH, and OSI. This study showed that oxidative stress is increased in PCOS even in the absence of MetS or IR. PON1 activity appears not to be affected in PCOS without MetS and IR. Several metabolic and antropometric risk factors may aggravate this altered oxidative state in PCOS.
C1 [Torun, Ayse Nur] Harran Univ, Sch Med, Dept Endocrinol, TR-63300 Sanliurfa, Turkey.
   [Vural, Mehmet; Camuzcuoglu, Hakan; Toy, Harun] Harran Univ, Sch Med, Dept Gynecol & Obstet, TR-63300 Sanliurfa, Turkey.
   [Cece, Hasan] Harran Univ, Sch Med, Dept Radiol, TR-63300 Sanliurfa, Turkey.
   [Aksoy, Nurten] Harran Univ, Sch Med, Dept Clin Biochem, TR-63300 Sanliurfa, Turkey.
C3 Harran University; Harran University; Harran University; Harran
   University
RP Torun, AN (corresponding author), Harran Univ, Sch Med, Dept Endocrinol, Yenisehir Campus, TR-63300 Sanliurfa, Turkey.
EM aysenurizol@yahoo.com
RI Vural, Mehmet/AAT-3123-2020; Inan, Nurten/AAA-8197-2021
CR Alberti G, 2005, EUR HEART J SUPPL, V7, pD3, DOI 10.1093/eurheartj/sui021
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NR 28
TC 21
Z9 21
U1 0
U2 5
PU INFORMA HEALTHCARE
PI NEW YORK
PA 52 VANDERBILT AVE, NEW YORK, NY 10017 USA
SN 0951-3590
J9 GYNECOL ENDOCRINOL
JI Gynecol. Endocrinol.
PD DEC
PY 2011
VL 27
IS 12
BP 988
EP 992
DI 10.3109/09513590.2011.569798
PG 5
WC Endocrinology & Metabolism; Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Obstetrics & Gynecology
GA 844VM
UT WOS:000296777700004
PM 21557696
DA 2025-06-11
ER

PT J
AU Alberga, AS
   Goldfield, GS
   Kenny, GP
   Hadjiyannakis, S
   Phillips, P
   Prud'homme, D
   Tulloch, H
   Gougeon, R
   Wells, GA
   Sigal, RJ
AF Alberga, A. S.
   Goldfield, G. S.
   Kenny, G. P.
   Hadjiyannakis, S.
   Phillips, P.
   Prud'homme, D.
   Tulloch, H.
   Gougeon, R.
   Wells, G. A.
   Sigal, R. J.
TI Healthy eating, aerobic and resistance training in youth (HEARTY): Study
   rationale, design and methods
SO CONTEMPORARY CLINICAL TRIALS
LA English
DT Article
DE Obesity; Adolescents; Resistance exercise; Aerobic exercise; Clinical
   trial; Magnetic Resonance Imaging
ID FAT-FREE MASS; OBESE CHILDREN; PHYSICAL-ACTIVITY; BODY-COMPOSITION;
   INSULIN SENSITIVITY; ADIPOSE-TISSUE; ADOLESCENTS; OVERWEIGHT; EXERCISE;
   PROGRAM
AB Purpose: The objective of the Healthy Eating Aerobic and Resistance Training in Youth (HEARTY) trial (ClinicalTrials.Gov # NC100195858) was to examine the effects of resistance training, with and without aerobic training, on percent body fat in sedentary, post-pubertal overweight or obese adolescents aged 14-18 years. This paper describes the HEARTY study rationale, design and methods.
   Methods: After a 4-week supervised low-intensity exercise run-in period, 304 overweight or obese adolescents with a body mass index >= 85th percentile for age and sex were randomized to 4 groups for 22 weeks (5 months): diet + aerobic exercise, diet + resistance exercise, diet + combined aerobic and resistance exercise, or a diet only waiting-list control. All participants received dietary counseling designed to promote healthy eating with a maximum daily energy deficit of -250 kcal.
   Outcomes: The primary outcome is percent body fat measured by Magnetic Resonance Imaging. Secondary outcomes include changes in anthropometry, regional body composition, resting energy expenditure, cardiorespiratory fitness, musculoskeletal fitness, cardiometabolic risk markers, and psychological health.
   Summary: To our knowledge, HEARTY is the largest clinical trial examining effects of aerobic training, resistance training, and combined aerobic and resistance training on changes in adiposity and cardiometabolic risk markers in overweight and obese adolescents. The findings will have important clinical implications regarding the role that resistance training should play in the management of adolescent obesity and its co-morbidities. (C) 2012 Elsevier Inc. All rights reserved.
C1 [Sigal, R. J.] Univ Calgary, Fac Med, Calgary, AB T2T 5C7, Canada.
   [Sigal, R. J.] Univ Calgary, Fac Kinesiol, Calgary, AB T2T 5C7, Canada.
   [Alberga, A. S.; Goldfield, G. S.; Kenny, G. P.; Prud'homme, D.] Univ Ottawa, Fac Hlth Sci, Sch Human Kinet, Ottawa, ON K1N 6N5, Canada.
   [Goldfield, G. S.; Hadjiyannakis, S.] Childrens Hosp Eastern Ontario, Res Inst, Hlth Act Living & Obes Res Grp HALO, Ottawa, ON K1H 8L1, Canada.
   [Phillips, P.; Sigal, R. J.] Ottawa Hosp, Res Inst, Clin Epidemiol Program, Ottawa, ON K1H 8L6, Canada.
   [Tulloch, H.] Univ Ottawa, Inst Heart, Prevent & Rehabil Ctr, Ottawa, ON K1Y 4W7, Canada.
   [Gougeon, R.] McGill Univ, Royal Victoria Hosp, Ctr Hlth, Nutr & Food Sci Ctr, Montreal, PQ H3A 1A1, Canada.
   [Wells, G. A.] Univ Ottawa, Dept Epidemiol & Community Med, Ottawa, ON K1H 8M5, Canada.
C3 University of Calgary; University of Calgary; University of Ottawa;
   University of Ottawa; Children's Hospital of Eastern Ontario; University
   of Ottawa; Ottawa Hospital Research Institute; University of Ottawa;
   University of Ottawa Heart Institute; McGill University; Royal Victoria
   Hospital; University of Ottawa
RP Sigal, RJ (corresponding author), Univ Calgary, Fac Med, 1820 Richmond Rd SW,Room 1898, Calgary, AB T2T 5C7, Canada.
EM rsigal@ucalgary.ca
RI Wells, George/M-4549-2017; Sigal, Ron/AAK-7627-2020
OI Goldfield, Gary/0000-0001-6216-7824
FU Canadian Institutes of Health Research (CIHR) [MCT-71979]; Alberta
   Heritage Foundation for Medical Research; University Research Chair;
   Research Chair from the Ottawa Hospital Research Institute; Children's
   Hospital of Eastern Ontario Volunteer Association Board; Canadian
   Diabetes Association
FX This study was supported by a Canadian Institutes of Health Research
   (CIHR) grant (MCT-71979). Dr. Sigal is supported by a Health Senior
   Scholar award from the Alberta Heritage Foundation for Medical Research,
   and was supported by a Research Chair from the Ottawa Hospital Research
   Institute during part of this trial. Dr. Gougeon is supported by a
   salary award from McGill University Health Center Research Institute.
   Dr. Glen Kenny is supported by a University Research Chair. Dr.
   Goldfield was supported by. a New Investigator Award from the Canadian
   Institutes of Health Research for part of the trial, and is currently
   supported by an Endowed Research Scholarship from the Children's
   Hospital of Eastern Ontario Volunteer Association Board. Ms. Angela
   Alberga is supported by a Doctoral Student Research Award from the
   Canadian Diabetes Association. We gratefully thank the HEARTY
   participants and all HEARTY research staff who assisted with training,
   data collection and analysis. Exercise specialists, personnel, MRI
   technologists and analysts: Krista Hind (deceased), Bruno Lemire, Marta
   Wein, Kim Robertson, Kim Fetch, Brittany Hanlon, Jane Yardley, Nadia
   Balaa, Karen Lopez, Pamela Martino, Kim Morin, the technologists at MRI
   plus clinic and CHEO and the Human Kinetics student volunteer personal
   trainers from the University of Ottawa. We also thank our dieticians for
   their consults and for dietary log analysis: Colleen Gilchrist, Pascale
   Messier and Kelley Phillips.
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NR 39
TC 31
Z9 34
U1 0
U2 34
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1551-7144
J9 CONTEMP CLIN TRIALS
JI Contemp. Clin. Trials
PD JUL
PY 2012
VL 33
IS 4
BP 839
EP 847
DI 10.1016/j.cct.2012.04.004
PG 9
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA 964QL
UT WOS:000305711700035
PM 22548962
DA 2025-06-11
ER

PT J
AU Cheng, YL
   Fei, Y
   Xu, ZM
   Huang, RY
   Jiang, YL
   Sun, LH
   Wang, XH
   Yu, SL
   Luo, YH
   Mao, XB
   Zhao, XY
AF Cheng, Yulan
   Fei, Yue
   Xu, Zemin
   Huang, Ruiyao
   Jiang, Yuling
   Sun, Lihan
   Wang, Xuehai
   Yu, Shali
   Luo, Yonghua
   Mao, Xiaobo
   Zhao, Xinyuan
TI Associations Between Brominated Flame Retardant Exposure and Depression
   in Adults: A Cross-Sectional Study
SO TOXICS
LA English
DT Article
DE NHANES; brominated flame retardants; depression; chemical mixture
   exposure; quantile-based g computation
ID GENDER-DIFFERENCES; UP-REGULATION; NEUROTOXICITY; HEALTH; PREVALENCE;
   BEHAVIORS; APOPTOSIS; ANXIETY; SAMPLES; SERUM
AB Background: Brominated flame retardants (BFRs) are a type of widespread pollutant that can be transmitted through particulate matter, such as dust in the air, and have been associated with various adverse health effects, such as diabetes, metabolic syndrome, and cardiovascular disease. However, there is limited research on the link between exposure to mixtures of BFRs and depression in the general population. Methods: To analyze the association between exposure to BFRs and depression in the population, nationally representative data from the National Health and Nutrition Examination Survey (NHANES; 2005-2016) were used. In the final analysis, a total of 8138 adults aged 20 years and older were included. To investigate the potential relationship between BFRs and outcomes, we used binary logistic regression, restricted cubic spline (RCS), quantile-based g computation (QGC), and weighted quantile sum (WQS) regression. Results: The findings showed that serum BFR concentrations were associated with depressive symptoms over a broad spectrum. Binary logistic regression and RCS analysis showed that certain BFRs, particularly PBB153, were significantly and positively associated with the incidence of depression, even after adjustment for various confounders (p < 0.05). Mixed exposure to BFRs was also found to be associated with depression in the population, with a stronger association in men. The two most influential BFRs, PBB153 and PBDE85, were identified in both mixed exposure models and are potential risk factors of concern. Conclusion: Our study identified new insights into the relationship between BFRs and depression, but sizable population-based cohort studies and toxicology mechanism studies will be needed to establish causality.
C1 [Cheng, Yulan; Mao, Xiaobo] Nantong Univ, Affiliated Haimen Hosp, Xinglin Coll, Nantong 226019, Peoples R China.
   [Cheng, Yulan; Fei, Yue; Xu, Zemin; Jiang, Yuling; Wang, Xuehai; Yu, Shali; Zhao, Xinyuan] Nantong Univ, Sch Publ Hlth, Dept Occupat Med & Environm Toxicol, Nantong Key Lab Environm Toxicol, Nantong 226019, Peoples R China.
   [Huang, Ruiyao] Nantong Univ, Xinglin Coll, Dept Clin Med, Nantong 226000, Peoples R China.
   [Sun, Lihan] Nantong Univ, Sch Med, Nantong 226001, Peoples R China.
   [Luo, Yonghua] Nantong Fourth Peoples Hosp, Nantong 226019, Peoples R China.
C3 Nantong University; Nantong University; Nantong University; Nantong
   University
RP Mao, XB (corresponding author), Nantong Univ, Affiliated Haimen Hosp, Xinglin Coll, Nantong 226019, Peoples R China.; Zhao, XY (corresponding author), Nantong Univ, Sch Publ Hlth, Dept Occupat Med & Environm Toxicol, Nantong Key Lab Environm Toxicol, Nantong 226019, Peoples R China.
EM nanyu295@163.com; 2317320024@stmail.ntu.edu.cn;
   2317320014@stmail.ntu.edu.cn; hry20041014@163.com; 18901533561@163.com;
   sunlihan2024@163.com; lankeqing3910@gmail.com; 7693539@ntu.edu.cn;
   ntluoyonghua@163.com; maoxiaobo@163.com; zhaoxinyuan@ntu.edu.cn
RI Xinyuan, Zhao/KIB-8956-2024; Hendrix, Tauska/IAQ-3526-2023; xiaobo,
   mao/KZU-0551-2024
OI Zhao, Xinyuan/0000-0002-7317-8016
FU National Natural Science Foundation of China;  [82204085]
FX This study was supported by the National Natural Science Foundation of
   China (82204085).
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NR 75
TC 0
Z9 0
U1 3
U2 3
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2305-6304
J9 TOXICS
JI Toxics
PD DEC
PY 2024
VL 12
IS 12
AR 918
DI 10.3390/toxics12120918
PG 17
WC Environmental Sciences; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Toxicology
GA Q5X1B
UT WOS:001385394200001
PM 39771133
OA gold
DA 2025-06-11
ER

PT J
AU Dullaart, RPF
   Al-Daghri, NM
   Ashina, M
   Bouzas-Mosquera, A
   Brunetti, ND
   Buechler, C
   Chen, HS
   Corrales, JJ
   D'Archivio, M
   Cas, AD
   Pino, GG
   Gomez-Abril, SA
   Gyori, D
   Haslacher, H
   Herder, C
   Kerstens, MN
   Koutsilieris, M
   Lombardi, C
   Lupattelli, G
   Mocsai, A
   Msaouel, P
   Orfao, A
   Ormazabal, P
   Pacher, R
   Perkmann, T
   Peteiro, J
   Plischke, M
   Reynaert, NL
   Ricci, MA
   Robles, NR
   Rocha, M
   Rutten, EPA
   Sabico, S
   Santamaria, F
   Santoro, F
   Schmid, A
   Schmidt, M
   Schytz, HW
   Shyu, KG
   Tada, H
   Thorand, B
   Valerio, G
   Vesely, DL
   Wu, TE
   Yamagishi, M
   Yeh, YT
AF Dullaart, Robin P. F.
   Al-Daghri, Nasser M.
   Ashina, Messoud
   Bouzas-Mosquera, Alberto
   Brunetti, Natale Daniele
   Buechler, Christa
   Chen, Harn-Shen
   Corrales, Juan J.
   D'Archivio, Massimo
   Cas, Alessandra Dei
   Pino, Guadalupe Garcia
   Gomez-Abril, Segundo A.
   Gyori, David
   Haslacher, Helmuth
   Herder, Christian
   Kerstens, Michiel N.
   Koutsilieris, Michael
   Lombardi, Carlo
   Lupattelli, Graziana
   Mocsai, Attila
   Msaouel, Pavlos
   Orfao, Alberto
   Ormazabal, Paulina
   Pacher, Richard
   Perkmann, Thomas
   Peteiro, Jesus
   Plischke, Max
   Reynaert, Niki L.
   Ricci, Maria Anastasia
   Robles, Nicolas Roberto
   Rocha, Milagros
   Rutten, Erica P. A.
   Sabico, Shaun
   Santamaria, Francesca
   Santoro, Francesco
   Schmid, Andreas
   Schmidt, Morten
   Schytz, Henrik Winther
   Shyu, Kou-Gi
   Tada, Hayato
   Thorand, Barbara
   Valerio, Giuliana
   Vesely, David L.
   Wu, Tzu-En
   Yamagishi, Masakazu
   Yeh, Yao-Tsung
TI Research update for articles published in EJCI in 2012
SO EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
LA English
DT Article
ID CORONARY-ARTERY-DISEASE; AUTOSOMAL RECESSIVE HYPERCHOLESTEROLEMIA;
   NEAR-INFRARED SPECTROSCOPY; LOW-FREQUENCY OSCILLATIONS;
   ISCHEMIC-HEART-DISEASE; SMOOTH-MUSCLE-CELLS; OXIDATIVE STRESS; METABOLIC
   SYNDROME; ADIPOSE-TISSUE; SOLUBLE CD163
C1 [Dullaart, Robin P. F.; Kerstens, Michiel N.] Univ Groningen, Univ Med Ctr Groningen, Dept Internal Med, Groningen 11451, Netherlands.
   [Al-Daghri, Nasser M.; Sabico, Shaun] King Saud Univ, Coll Sci, Dept Biochem, Biomarkers Res Program, Riyadh 11451, Saudi Arabia.
   [Al-Daghri, Nasser M.; Sabico, Shaun] King Saud Univ, Coll Sci, Dept Biochem, Prince Mutaib Chair Biomarkers Osteoporosis, Riyadh, Saudi Arabia.
   [Ashina, Messoud; Schytz, Henrik Winther] Univ Copenhagen, Fac Hlth & Med Sci, Danish Headache Ctr, Human Migraine Res Unit,Dept Neurol,Glostrup Hosp, Copenhagen, Denmark.
   [Bouzas-Mosquera, Alberto; Peteiro, Jesus] Hosp Univ A Coruna, Dept Cardiol, La Coruna, Spain.
   [Brunetti, Natale Daniele; Santoro, Francesco] Univ Foggia, D-93053 Foggia, Italy.
   [Buechler, Christa; Schmid, Andreas] Univ Regensburg, Dept Internal Med 1, Regensburg 112, Germany.
   [Chen, Harn-Shen; Wu, Tzu-En] Natl Yang Ming Univ, Fac Med, Sch Med, Taipei, Taiwan.
   [Chen, Harn-Shen] Taipei Vet Gen Hosp, Dept Med, Div Endocrinol & Metab, Taipei, Taiwan.
   [Corrales, Juan J.] Univ Hosp Salamanca, Dept Med, Serv Endocrinol, Salamanca, Spain.
   [D'Archivio, Massimo; Ormazabal, Paulina] Italian Natl Inst Hlth, Dept Vet Publ Hlth & Food Safety, I-43100 Rome, Italy.
   [Cas, Alessandra Dei] Univ Parma, Dept Clin & Expt Med, Parma, Italy.
   [Pino, Guadalupe Garcia] Hosp Infanta Cristina, Serv Nefrol, Badajoz, Spain.
   [Gomez-Abril, Segundo A.] Univ Hosp Dr Peset, Serv Gen Surg & Digest Syst, Valencia, Spain.
   [Gomez-Abril, Segundo A.; Rocha, Milagros] Fdn Promot Healthcare & Biomed Res Valencian Comm, Valencia, Spain.
   [Gyori, David; Mocsai, Attila] Semmelweis Univ, Sch Med, Dept Physiol, Budapest, Hungary.
   [Gyori, David; Mocsai, Attila] Hungarian Acad Sci, MTA SE Lendulet Inflammat Physiol Res Grp, H-1085 Budapest, Hungary.
   [Gyori, David; Mocsai, Attila] Semmelweis Univ, Budapest, Hungary.
   [Haslacher, Helmuth; Perkmann, Thomas] Med Univ Vienna, Dept Lab Med, Vienna, Austria.
   [Herder, Christian] Univ Dusseldorf, German Diabet Ctr, Leibniz Ctr Diabet Res, Inst Clin Diabetol, Dusseldorf, Germany.
   [Herder, Christian; Thorand, Barbara] German Ctr Diabet Res DZD eV, Partner Neuherberg, Tubingen 11528, Germany.
   [Koutsilieris, Michael; Msaouel, Pavlos] Univ Athens, Sch Med, Dept Expt Physiol, Athens, Greece.
   [Lombardi, Carlo] Univ Brescia, Dept Expt & Appl Med, I-06100 Brescia, Italy.
   [Lupattelli, Graziana; Ricci, Maria Anastasia] Univ Perugia, Dept Med, Perugia, 10467, Italy.
   [Msaouel, Pavlos] Albert Einstein Coll Med, Dept Internal Med, Jacobi Med Ctr, E-37008 Bronx, NY USA.
   [Orfao, Alberto] Univ Salamanca, Dept Med, E-37008 Salamanca, Spain.
   [Orfao, Alberto] Univ Salamanca, Gen Cytometry Serv, Salamanca, Spain.
   [Pacher, Richard] Med Univ Vienna, Div Cardiol, Dept Internal Med 2, Vienna, Austria.
   [Plischke, Max] Med Univ Vienna, Div Nephrol & Dialysis, Dept Internal Med 2, Vienna, Austria.
   [Reynaert, Niki L.] Maastricht Univ Med Ctr, Dept Resp Med, E-37008 Maastricht, Netherlands.
   [Robles, Nicolas Roberto] Univ Salamanca, Sch Med, Cardiovasc Risk Inst, Salamanca, Spain.
   [Rocha, Milagros] Univ Hosp Dr Peset, Serv Endocrinol, Valencia, Spain.
   [Rocha, Milagros] Univ Valencia, Fac Med, CIBER Hepat & Digest Dis, CIBERehd CB06 04 0071 Res Grp, Valencia, Spain.
   [Rutten, Erica P. A.] Ctr Expertise Chron Organ Failure, CIRO, Dept Res & Educ, Horn, Netherlands.
   [Santamaria, Francesca] Univ Naples Federico II, Dept Translat Med Sci, DK-8000 Naples, Italy.
   [Schmidt, Morten] Aarhus Univ Hosp, Dept Clin Epidemiol, Aarhus, Denmark.
   [Schmidt, Morten] Aarhus Univ Hosp, Dept Cardiol, Skejby, Denmark.
   [Shyu, Kou-Gi] Shin Kong Wu Ho Su Mem Hosp, Div Cardiol, Taipei, Taiwan.
   [Tada, Hayato; Yamagishi, Masakazu] Kanazawa Univ, Grad Sch Med, Div Cardiovasc Med, Kanazawa, Ishikawa, Japan.
   [Thorand, Barbara] German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Inst Epidemiol 2, Neuherberg, Germany.
   [Valerio, Giuliana] Parthenope Univ, Dept Movement Sci & Wellness, Naples, Italy.
   [Vesely, David L.] Univ S Florida, James A Haley VA Med Ctr, Cardiac Hormone Ctr, Div Endocrinol Diabet & Metab,Dept Med, Tampa, FL USA.
   [Vesely, David L.] Univ S Florida, James A Haley VA Med Ctr, Cardiac Hormone Ctr, Div Endocrinol Diabet & Metab,Dept Mol Pharmacol, Tampa, FL USA.
   [Vesely, David L.] Univ S Florida, James A Haley VA Med Ctr, Cardiac Hormone Ctr, Div Endocrinol Diabet & Metab,Dept Physiol, Tampa, FL USA.
   [Vesely, David L.] Univ S Florida, Morsani Sch Med, Tampa, FL USA.
   [Wu, Tzu-En] Shin Kong Wu Ho Su Mem Hosp, Dept Ophthalmol, Taipei, Taiwan.
   [Yeh, Yao-Tsung] Fooyin Univ, Dept Med Lab Sci & Biotechnol, Kaohsiung, Taiwan.
C3 University of Groningen; King Saud University; King Saud University;
   University of Copenhagen; Complejo Hospitalario Universitario A Coruna;
   University of Foggia; University of Regensburg; National Yang Ming Chiao
   Tung University; Taipei Veterans General Hospital; Istituto Superiore di
   Sanita (ISS); University of Parma; University Hospital of Parma;
   Semmelweis University; Hungarian Academy of Sciences; Semmelweis
   University; Medical University of Vienna; Heinrich Heine University
   Dusseldorf; Leibniz Association; Deutsches Diabetes-Zentrum (DDZ);
   German Center for Diabetes Research (DZD); National & Kapodistrian
   University of Athens; Athens Medical School; University of Brescia;
   University of Perugia; Jacobi Medical Center; University of Salamanca;
   University of Salamanca; Medical University of Vienna; Medical
   University of Vienna; Maastricht University; Maastricht University
   Medical Centre (MUMC); University of Salamanca; CIBER - Centro de
   Investigacion Biomedica en Red; CIBEREHD; University of Valencia;
   University of Naples Federico II; Aarhus University; Aarhus University;
   Shin Kong Wu Ho Su Memorial Hospital; Kanazawa University; Helmholtz
   Association; Helmholtz-Center Munich - German Research Center for
   Environmental Health; Parthenope University Naples; State University
   System of Florida; University of South Florida; State University System
   of Florida; University of South Florida; State University System of
   Florida; University of South Florida; State University System of
   Florida; University of South Florida; Shin Kong Wu Ho Su Memorial
   Hospital; Fooyin University
EM ejci.editor@gmail.com
RI Orfao, Alberto/B-5801-2017; Schmidt, Morten/F-5048-2013; Mocsai,
   Attila/B-2792-2008; Santoro, Francesco/AAK-7009-2021; Ashina,
   Messoud/AFU-1246-2022; D'Archivio, massimo/Z-4633-2019; Santamaria,
   Francesca/AAC-3503-2022; Schytz, Henrik/JZT-0830-2024; Msaouel,
   Pavlos/D-4297-2011; Buechler, Christa/AAH-3004-2020; Brunetti,
   Natale/AGH-8401-2022; Thorand, Barbara/B-5349-2014; GOMEZ-ABRIL,
   SEGUNDO/AAB-2955-2019; Vesely, David/A-7807-2009; Robles,
   Nicolas/I-4421-2019; Perkmann, Thomas/JAC-5945-2023; Koutsilieris,
   Michael/AAD-3648-2019; Al-Daghri, Nasser/A-8360-2011; Bouzas-Mosquera,
   Alberto/S-3919-2018; Reynaert, Niki/C-5491-2014; Gyori, David
   S./F-6276-2019; Schmid, Andreas/L-5886-2017; Rocha,
   Milagros/I-4987-2015; Haslacher, Helmuth/D-4233-2013; Brunetti, Natale
   Daniele/P-6424-2015; lombardi, carlo/O-2130-2013; Sabico,
   Shaun/C-9086-2011
OI Bouzas-Mosquera, Alberto/0000-0002-2741-732X; Perkmann,
   Thomas/0000-0002-7976-0285; Yeh, Yao-Tsung/0000-0002-7780-7983;
   Al-Daghri, Nasser/0000-0001-5472-1725; Gyori, David
   S./0000-0002-2048-6752; D'Archivio, Massimo/0000-0001-8104-3421;
   Santoro, Francesco/0000-0001-9909-6513; Torres Sanchez, Maria
   Teresa/0000-0003-4265-4945; Schmidt, Morten/0000-0002-4935-4059; Schmid,
   Andreas/0000-0002-6684-9088; Gomez-Abril, Segundo/0000-0003-3523-1821;
   Rocha, Milagros/0000-0003-2923-6546; Haslacher,
   Helmuth/0000-0003-4605-2503; Brunetti, Natale
   Daniele/0000-0001-9610-7408; Valerio, Giuliana/0000-0001-5063-4333;
   lombardi, carlo/0000-0002-7120-5877; Sabico, Shaun/0000-0002-5248-2350;
   Schytz, Henrik Winther/0000-0002-6262-2986; Robles, Nicolas
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NR 113
TC 0
Z9 0
U1 0
U2 27
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0014-2972
EI 1365-2362
J9 EUR J CLIN INVEST
JI Eur. J. Clin. Invest.
PD OCT
PY 2014
VL 44
IS 10
BP 1010
EP 1023
DI 10.1111/eci.12319
PG 14
WC Medicine, General & Internal; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Research & Experimental Medicine
GA AQ4ML
UT WOS:000342771500015
DA 2025-06-11
ER

PT J
AU Masoumvand, M
   Ramezani, E
   Rahimi, VB
   Askari, VR
AF Masoumvand, Mohammad
   Ramezani, Elmira
   Rahimi, Vafa Baradaran
   Askari, Vahid Reza
TI Promising Influences of Moringa oleifera in Functional Foods
   against Metabolic Syndrome: A Comprehensive and Mechanistic Review
SO ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS
LA English
DT Review
DE Moringa oleifera; metabolic syndrome; diabetes; dyslipidemia; obesity;
   herbal alternatives
ID DIET-INDUCED OBESITY; LEAF EXTRACT; ANTIOXIDANT ACTIVITY; AMELIORATES
   GLUCOSE; WAIST CIRCUMFERENCE; INSULIN-RESISTANCE; OXIDATIVE STRESS;
   LIPID-METABOLISM; AQUEOUS EXTRACT; CUTOFF POINTS
AB Metabolic syndrome (MetS) is now considered a global issue with a growing financial and health impact. Numerous herbal alternatives have been examined and researched due to the ever-increasing demand for new medications to treat metabolic syndrome disorders. People have empirically employed Moringa oleifera (MO), a native plant to several Asian nations, for a variety of diseases. We sought to examine recent research on MO in MetS and its potential mechanism of action in the current review. Four databases, including PubMed, Scopus, Web of Sciences, and Google Scholar, were thoroughly searched, and the data were then compiled. In total, 146 papers covering nonclinical and clinical MO investigations in metabolic syndrome-related disorders are included in this study. Numerous research confirmed MO's positive impact on the control of blood glucose, blood pressure, hyperlipidemia, and obesity. Many molecular processes have been investigated, including increasing glucose transporter type 4 (GLUT4) expression, inhibition of beta-Hydroxy-beta-methylglutaryl-coenzyme A (HMG-CoA), alpha-glucosidase inhibiting, AMP-activated protein kinase (AMPK) activation, and other suggested mechanisms. The current review established much data favoring MO's potential advantages in metabolic syndrome. However, further research involving human studies is required in this area to determine whether Moringa can effectively treat metabolic syndrome.
C1 [Masoumvand, Mohammad] Mashhad Univ Med Sci, Fac Med, Dept Nutr, Mashhad, Iran.
   [Ramezani, Elmira] Iran Univ Med Sci, Fac Publ Hlth, Dept Nutr, Tehran, Iran.
   [Rahimi, Vafa Baradaran] Mashhad Univ Med Sci, Fac Med, Dept Cardiovasc Dis, Mashhad, Iran.
   [Askari, Vahid Reza] Mashhad Univ Med Sci, Int UNESCO Ctr Hlth Related Basic Sci & Human Nutr, Mashhad, Iran.
   [Askari, Vahid Reza] Mashhad Univ Med Sci, Appl Biomed Res Ctr, Mashhad, Iran.
C3 Mashhad University of Medical Sciences; Iran University of Medical
   Sciences; Mashhad University of Medical Sciences; Mashhad University of
   Medical Sciences; Mashhad University of Medical Sciences
RP Askari, VR (corresponding author), Mashhad Univ Med Sci, Int UNESCO Ctr Hlth Related Basic Sci & Human Nutr, Mashhad, Iran.; Askari, VR (corresponding author), Mashhad Univ Med Sci, Appl Biomed Res Ctr, Mashhad, Iran.
EM askariv@mums.ac.ir
RI Askari, Vahid Reza/ABB-8991-2020; Baradaran Rahimi, Vafa/AAR-4523-2021
OI Baradaran Rahimi, Vafa/0000-0003-2320-5095
FX Declared none.
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NR 111
TC 3
Z9 3
U1 0
U2 2
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1871-5303
EI 2212-3873
J9 ENDOCR METAB IMMUNE
JI Endocr. Metab. Immune Disord.-Drug Targets
PY 2024
VL 24
IS 12
BP 1355
EP 1370
DI 10.2174/0118715303269893231207071440
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WC Endocrinology & Metabolism; Immunology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Immunology; Pharmacology & Pharmacy
GA C8D6L
UT WOS:001291623700010
PM 38279759
DA 2025-06-11
ER

PT J
AU Hininger-Favier, I
   Benaraba, R
   Coves, S
   Anderson, RA
   Roussel, AM
AF Hininger-Favier, Isabelle
   Benaraba, Rachida
   Coves, Sara
   Anderson, Richard A.
   Roussel, Anne-Marie
TI Green Tea Extract Decreases Oxidative Stress and Improves Insulin
   Sensitivity in an Animal Model of Insulin Resistance, the Fructose-Fed
   Rat
SO JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION
LA English
DT Article
DE green tea; oxidative stress; insulin resistance; fructose-rich diet
ID METABOLIC SYNDROME; DNA-DAMAGE; POLYPHENOLS; MECHANISMS; OBESITY; DIET;
   EGCG; SUPPLEMENTATION; INTERVENTION; PROTECTS
AB Background: Tea polyphenols, as both insulin potentiating factors and antioxidants. are postulated to act in preventing the metabolic syndrome, which is characterized by insulin resistance, dyslipidemia. and increased oxidative stress.
   Objective and Methods: Using an animal model of insulin resistance, our objective was to determine the effects of a green tea extract on oxidative stress parameters and insulin sensitivity. Wistar rats, 10 per group. received a high-fructose diet (FD) for 6 weeks, or the same diet (FD) plus 1 or 2 g of green tea solids/kg diet.
   Results: Signs of insulin resistance (hyperglycemia, hypertriglyceridemia, and hyperinsulinemia) developed its rats receiving the FD. but not in those of the control group. In contrast, animals receiving added tea solids exhibited decreases in glycemia, insulinemia, and triglyceridemia, consistent with an insulin-potentiating effect of tea. In parallel, oxidative stress was decreased by tea consumption with lower plasma lipid peroxidation, sulfhydryl (S H) group oxidation, and DNA oxidative damage. In summary, the addition of green tea extracts to the diet, inducing insulin resistance, led to protective effects of green tea against both oxidative stress and insulin resistance.
   Conclusions: These data suggest that green tea may be beneficial for people with decreased insulin sensitivity and increased oxidative stress, such as those with the metabolic syndrome or type 2 diabetes.
C1 [Hininger-Favier, Isabelle; Benaraba, Rachida; Roussel, Anne-Marie] INSERM, U884, F-38000 Grenoble, France.
   [Hininger-Favier, Isabelle; Benaraba, Rachida; Roussel, Anne-Marie] Univ Grenoble 1, LBFA, F-38041 Grenoble 1, France.
   [Coves, Sara] Unilever, F-92824 Rueil Malmaison, France.
   [Anderson, Richard A.] Beltsville Human Nutr Res Ctr, Diet Genom & Immunol Lab, Beltsville, MD USA.
C3 Institut National de la Sante et de la Recherche Medicale (Inserm);
   Communaute Universite Grenoble Alpes; Universite Grenoble Alpes (UGA);
   Unilever
RP Roussel, AM (corresponding author), Univ Grenoble 1, F-38700 Grenoble, France.
EM Anne-Marie.Roussel@ujr-grenoble.fr
OI hininger-favier, isabelle/0000-0001-6726-7533
FU Unilever France
FX We are grateful to Unilever France for supporting this work by providing
   a Research Grant.
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NR 56
TC 77
Z9 86
U1 0
U2 23
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 0731-5724
EI 1541-1087
J9 J AM COLL NUTR
JI J. Am. Coll. Nutr.
PD AUG
PY 2009
VL 28
IS 4
BP 355
EP 361
DI 10.1080/07315724.2009.10718097
PG 7
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 583AE
UT WOS:000276642300002
PM 20368373
DA 2025-06-11
ER

PT J
AU Tsitsimpikou, C
   Tsarouhas, K
   Kioukia-Fougia, N
   Skondra, C
   Fragkiadaki, P
   Papalexis, P
   Stamatopoulos, P
   Kaplanis, I
   Hayes, AW
   Tsatsakis, A
   Rentoukas, E
AF Tsitsimpikou, Christina
   Tsarouhas, Konstantinos
   Kioukia-Fougia, Nassia
   Skondra, Christina
   Fragkiadaki, Persefoni
   Papalexis, Peter
   Stamatopoulos, Panagiotis
   Kaplanis, Ioannis
   Hayes, A. Wallace
   Tsatsakis, Aristidis
   Rentoukas, Elias
TI Dietary supplementation with tomato-juice in patients with metabolic
   syndrome: A suggestion to alleviate detrimental clinical factors
SO FOOD AND CHEMICAL TOXICOLOGY
LA English
DT Article
DE Tomato juice; Metabolic syndrome; Inflammation; Insulin resistance
ID ASYMMETRIC DIMETHYLARGININE ADMA; TOTAL ANTIOXIDANT CAPACITY;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; ENDOTHELIAL DYSFUNCTION; LOWER
   PREVALENCE; LIPID PROFILE; VITAMIN-C; LYCOPENE; RATS
AB Lycopene, a carotenoid, is known for its antioxidant properties. Little is known, though, about the relationship of dietary tomato-juice intake and risks factors, like inflammation, insulin resistance and hyperlipidemia, implicated in metabolic syndrome. In the present study, we examined whether supplementation with tomato-juice has any implication on the risk status of patients with metabolic syndrome. A comparative study was conducted in 27 individuals diagnosed with metabolic syndrome. Fifteen of them were instructed to use commercially available tomato-juice as refreshment 4 times a week over a period of two months and twelve individuals served as the control group. Several parameters reflective of the metabolic syndrome were monitored both in the group supplemented with tomato juice and in the control group (ADMA for entdothelial function, TNF-alpha, and IL-6 for inflammation, FIRI for insulin resistance). There was a significant improvement in the inflammation status and the endothelial dysfunction of the tomato-juice supplemented patients. At the same time, insulin resistance improved and a pronounced decrease in LDL was recorded, along with a slight increase in HDL. The results of the present study suggest an alleviating effect of tomato-juice with regard to risk factors associated with metabolic syndrome. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Tsitsimpikou, Christina] Gen Chem State Lab Greece, Athens 11521, Greece.
   [Tsarouhas, Konstantinos; Papalexis, Peter] Gen Hosp Karditsa, Dept Cardiol, Terma Tavropou, Karditsa, Greece.
   [Kioukia-Fougia, Nassia] Olymp Athlet Ctr Athens, Doping Control Lab Athens, Maroussi 15123, Greece.
   [Skondra, Christina] Alfrief Krupp Hosp, Dept Internal Med, Clin Nephrol & Endocrinol 2, D-45131 Essen, Germany.
   [Fragkiadaki, Persefoni; Tsatsakis, Aristidis] Univ Crete, Sch Med, Toxicol Lab, Iraklion 71409, Crete, Greece.
   [Stamatopoulos, Panagiotis] ORTHOBIOTIKI Prevent & Antiaging, Athens 15125, Greece.
   [Kaplanis, Ioannis; Rentoukas, Elias] Amalia Fleming Gen Hosp, Cardiol Dept 2, Athens 15127, Greece.
   [Hayes, A. Wallace] Harvard Univ, Sch Publ Hlth, Boston, MA 02115 USA.
C3 University of Crete; Harvard University; Harvard T.H. Chan School of
   Public Health
RP Tsatsakis, A (corresponding author), Univ Crete, Sch Med, Toxicol Lab, Iraklion 71409, Crete, Greece.
EM toxlab.uoc@gmail.com
RI Papalexis, Petros/H-4222-2019; TSATSAKIS, ARISTIDIS/H-2890-2013;
   Tsarouhas, Konstantinos/H-5793-2019
OI TSATSAKIS, ARISTIDIS/0000-0003-3824-2462; Tsarouhas,
   Konstantinos/0000-0003-2651-3579; Papalexis, Petros/0000-0003-3565-4066
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NR 44
TC 41
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PU PERGAMON-ELSEVIER SCIENCE LTD
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PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0278-6915
EI 1873-6351
J9 FOOD CHEM TOXICOL
JI Food Chem. Toxicol.
PD DEC
PY 2014
VL 74
BP 9
EP 13
DI 10.1016/j.fct.2014.08.014
PG 5
WC Food Science & Technology; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Toxicology
GA AY0GD
UT WOS:000347274600002
PM 25194627
DA 2025-06-11
ER

PT J
AU Shen, JH
   Bi, YL
   Das, UN
AF Shen, Junhui
   Bi, Yan-Long
   Das, Undurti N.
TI Potential rote of polyunsaturated fatty acids in diabetic retinopathy
SO ARCHIVES OF MEDICAL SCIENCE
LA English
DT Article
DE vascular endothelial growth factor; hemorheology; inflammation;
   brain-derived neurotrophic factor; diabetic retinopathy; polyunsaturated
   fatty acids
ID ENDOTHELIAL GROWTH-FACTOR; METABOLIC SYNDROME-X; BLOOD-RETINAL BARRIER;
   ARACHIDONIC-ACID; HYPERTENSIVE PATIENTS; INDUCED CYTOTOXICITY; OXIDATIVE
   STRESS; OBESITY INDEXES; VEGF; MELLITUS
AB Diabetic retinopathy (DR) is a serious complication of long-standing diabetes mellitus. It affects about 25% of all patients with diabetes mellitus and causes a significant decrease in the quality of life. Despite many years of research, the exact pathway that leads to the development and progression of DR is not clear. Recent studies suggest that polyunsaturated fatty acids (PUFAs) and their metabolites could play a significant role in DR. There is evidence to suggest that an imbalance between pro- and anti-inflammatory eicosanoids and enhanced production of pro-angiogenic factors may initiate the onset and progression of DR. This implies that PUFAs and their metabolites that possess anti-inflammatory actions and suppress the production of angiogenic factors could be employed in the prevention and management of DR.
C1 [Shen, Junhui; Bi, Yan-Long] Tongji Univ, Sch Med, Tongji Hosp, Dept Ophthalmol, Shanghai 200065, Peoples R China.
   [Das, Undurti N.] UND Life Sci, Hefei, Peoples R China.
C3 Tongji University
RP Bi, YL (corresponding author), Tongji Univ, Sch Med, Tongji Hosp, Dept Ophthalmol, Shanghai 200065, Peoples R China.
EM biyanlong@tongji.edu.cn; Undurti@hotmail.com
RI Das, Undurti/A-7918-2009
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NR 84
TC 19
Z9 19
U1 1
U2 18
PU TERMEDIA PUBLISHING HOUSE LTD
PI POZNAN
PA KLEEBERGA ST 2, POZNAN, 61-615, POLAND
SN 1734-1922
EI 1896-9151
J9 ARCH MED SCI
JI Arch. Med. Sci.
PD DEC
PY 2014
VL 10
IS 6
BP 1167
EP 1174
DI 10.5114/aoms.2014.47826
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA AX5DS
UT WOS:000346947800016
PM 25624855
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Ge, F
   Pietromonaco, PR
   DeBuse, CJ
   Powers, SI
   Granger, DA
AF Ge, Fiona
   Pietromonaco, Paula R.
   DeBuse, Casey J.
   Powers, Sally I.
   Granger, Douglas A.
TI Concurrent and prospective associations between HPA axis activity and
   depression symptoms in newlywed women
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE Depression; Cortisol; Dehydroepiandrosterone-sulfate; Gender; Marital
   interactions
ID DEHYDROEPIANDROSTERONE-SULFATE; CORTISOL/DHEAS-RATIO; METABOLIC
   SYNDROME; MISSING DATA; STRESS; ATTACHMENT; HEALTH; RESPONSES;
   REACTIVITY; CHILDHOOD
AB We investigated the extent to which individual differences in activity of the hypothalamic pituitary adrenal axis (HPA) are associated with depressive symptoms among newlywed couples. Participants were 218 couples (M age 28.4 years; 94% White) who provided 5 saliva samples (later assayed for cortisol and DHEA-S) before and after participation in a discussion of a major area of disagreement in their relationship. Depressive symptoms were assessed initially, and approximately 19- and 37-months later. Results revealed an interactive effect suggesting that concordant levels of cortisol and DHEA-S (either both high or both low) were concurrently and prospectively associated with higher depression scores. Interestingly, this interactive effect was observed for wives only - not for husbands. These observations underscore contemporary theoretical assumptions that the expression of the association between HPA activity and depression is dependent on factors related to the interaction between characteristics of the person and features of the social environment, and moderated by co-occurring variation in endocrine milieu. (C) 2016 Elsevier Ltd. All rights reserved.
C1 [Ge, Fiona; Pietromonaco, Paula R.; DeBuse, Casey J.; Powers, Sally I.; Granger, Douglas A.] Univ Massachusetts, Dept Psychol & Brain Sci, 135 Hicks Way,Tobin Hall, Amherst, MA 01003 USA.
   [Granger, Douglas A.] Univ Calif Irvine, Inst Interdisciplinary Salivary Biosci Res, Irvine, CA 92697 USA.
   [Granger, Douglas A.] Johns Hopkins Univ, Sch Nursing, Bloomberg Sch Publ Hlth, Sch Med, Baltimore, MD 21218 USA.
C3 University of Massachusetts System; University of Massachusetts Amherst;
   University of California System; University of California Irvine; Johns
   Hopkins University; Johns Hopkins Bloomberg School of Public Health
RP Pietromonaco, PR (corresponding author), Univ Massachusetts, Dept Psychol & Brain Sci, 135 Hicks Way,Tobin Hall, Amherst, MA 01003 USA.
EM monaco@psych.umass.edu
RI Pietromonaco, Paula/JXL-3667-2024
OI Powers, Sally/0000-0002-7650-1157
CR [Anonymous], NSDUH SER H
   [Anonymous], 2013, Mental health action plan 2013-2020
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NR 58
TC 4
Z9 5
U1 0
U2 8
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
EI 1873-3360
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD NOV
PY 2016
VL 73
BP 125
EP 132
DI 10.1016/j.psyneuen.2016.07.217
PG 8
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA DY7QQ
UT WOS:000385324800015
PM 27494071
OA Green Accepted, Bronze, Green Submitted
DA 2025-06-11
ER

PT J
AU Akaberi, M
   Hosseinzadeh, H
AF Akaberi, Maryam
   Hosseinzadeh, Hosein
TI Grapes (Vitis vinifera) as a Potential Candidate for the Therapy
   of the Metabolic Syndrome
SO PHYTOTHERAPY RESEARCH
LA English
DT Review
DE Vitis vinifera; grape; metabolic syndrome; hyperglycemia;
   hyperlipidemia; diabetes mellitus
ID HIGH-FAT DIET; SEED PROANTHOCYANIDIN EXTRACT; SKIN EXTRACT; OXIDATIVE
   STRESS; RED WINE; IN-VITRO; POLYPHENOLIC FRACTION; ANTIOXIDANT STATUS;
   SERUM PARAOXONASE; HEPATIC STEATOSIS
AB Metabolic syndrome is associated with several disorders, including hypertension, diabetes, hyperlipidemia as well as cardiovascular diseases and stroke. Plant-derived polyphenols, compounds found in numerous plant species, play an important role as potential treatments for components of metabolic syndrome. Studies have provided evidence for protective effects of various polyphenol-rich foods against metabolic syndrome. Fruits, vegetables, cereals, nuts, and berries are rich in polyphenolic compounds. Grapes (Vitis vinifera), especially grape seeds, stand out as rich sources of polyphenol potent antioxidants and have been reported helpful for inhibiting the risk factors involved in the metabolic syndrome such as hyperlipidemia, hyperglycemia, and hypertension. There are also many studies about gastroprotective, hepatoprotective, and anti-obesity effects of grape polyphenolic compounds especially proanthocyanidins in the literature. The present study investigates the protective effects of grape seeds in metabolic syndrome. The results of this study show that grape polyphenols have significant effects on the level of blood glucose, lipid profile, blood pressure, as well as beneficial activities in liver and heart with various mechanisms. In addition, the pharmacokinetics of grape polyphenols is discussed. More detailed mechanistic investigations and phytochemical studies for finding the exact bioactive component(s) and molecular signaling pathways are suggested. Copyright (c) 2016 John Wiley & Sons, Ltd.
C1 [Akaberi, Maryam] Mashhad Univ Med Sci, Sch Pharm, Dept Pharmacognosy, Mashhad, Iran.
   [Akaberi, Maryam] Mashhad Univ Med Sci, Student Res Comm, Mashhad, Iran.
   [Hosseinzadeh, Hosein] Mashhad Univ Med Sci, Sch Pharm, Dept Pharmacodynamy & Toxicol, Pharmaceut Res Ctr, Mashhad, Iran.
C3 Mashhad University of Medical Sciences; Mashhad University of Medical
   Sciences; Mashhad University of Medical Sciences
RP Hosseinzadeh, H (corresponding author), Mashhad Univ Med Sci, Sch Pharm, Dept Pharmacodynamy & Toxicol, Pharmaceut Res Ctr, Mashhad, Iran.
EM hosseinzadehh@mums.ac.ir
RI Akaberi, Maryam/AAS-9054-2020; Hosseinzadeh, Hossein/F-3013-2010
OI Hosseinzadeh, Hossein/0000-0002-3483-851X; Akaberi,
   Maryam/0000-0002-3971-2377
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NR 142
TC 147
Z9 152
U1 2
U2 114
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0951-418X
EI 1099-1573
J9 PHYTOTHER RES
JI Phytother. Res.
PD APR
PY 2016
VL 30
IS 4
BP 540
EP 556
DI 10.1002/ptr.5570
PG 17
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA DJ1VQ
UT WOS:000373993500003
PM 26800498
DA 2025-06-11
ER

PT J
AU Hao, L
   Lu, XL
   Sun, M
   Li, K
   Shen, LM
   Wu, T
AF Hao, Lei
   Lu, Xiaoling
   Sun, Min
   Li, Kai
   Shen, Lingmin
   Wu, Tao
TI Protective effects of L-arabinose in high-carbohydrate, high-fat
   diet-induced metabolic syndrome in rats
SO FOOD & NUTRITION RESEARCH
LA English
DT Article
DE L-Arabinose; metabolic syndrome; hypertension; insulin resistance;
   adipocytokines
ID INTESTINAL SUCRASE ACTIVITY; SUCROSE INGESTION; OBESITY;
   STEATOHEPATITIS; EXPRESSION; STRESS; MODEL
AB Background: L-Arabinose is a non-caloric sugar, which could affect glucose and lipid metabolism and suppress obesity. However, few reports have described the effect of L-arabinose in metabolic syndrome, a combination of medical disorders that increase the risk of diabetes and cardiovascular disease.
   Objective: This study was conducted to explore the effects of L-arabinose in rats with metabolic syndrome induced by a high-carbohydrate, high-fat ( HCHF) diet.
   Methods: After the rat model for metabolic syndrome was successfully established, L-arabinose was administrated by oral gavage for 6 weeks. The biochemical index and histological analysis were measured, and the expression levels of genes related to fatty acid metabolism were analyzed using real-time PCR.
   Results: Following treatment with L-arabinose, metabolic syndrome rats had an obvious reduction in body weight, systolic blood pressure, diastolic blood pressure, fasting blood glucose, triglycerides, total cholesterol, serum insulin, TNF-alpha, and leptin. Further study showed that treatment with L-arabinose significantly increased the expression of mRNA for hepatic CPT-1 alpha and PDK4, but the expression of mRNA for hepatic ACC alpha was reduced.
   Conclusions: This work suggests that L-arabinose could lower body weight, Lee's index, and visceral index and improve dyslipidemia, insulin resistance, inflammation, and viscera function, which indicate that it might be a promising candidate for therapies combating metabolic syndrome.
C1 [Hao, Lei; Lu, Xiaoling; Sun, Min; Li, Kai; Shen, Lingmin; Wu, Tao] Tianjin Univ Sci & Technol, Coll Food Engn & Biotechnol, Minist Educ, Key Lab Food Nutr & Safety, Tianjin 300457, Peoples R China.
C3 Ministry of Education - China; Tianjin University Science & Technology
RP Lu, XL (corresponding author), Tianjin Univ Sci & Technol, Tianjin Econ & Technol Dev Area TEDA, 29,13th Ave, Tianjin 300457, Peoples R China.
EM lu_xiaoling@sina.com
RI Wu, Tao/E-7769-2011
OI Wu, Tao/0000-0002-0629-8421
FU National Science and Technology Support Project (125 Program)
   [2011BAD23B03]
FX This study was supported by grants from National Science and Technology
   Support Project (125 Program, No. 2011BAD23B03).
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NR 34
TC 50
Z9 54
U1 4
U2 38
PU SWEDISH NUTRITION FOUNDATION-SNF
PI LUND
PA IDEON SCIENCE PARK, BESOK SCHEELEV 17 BETA 5, 3V, LUND, 223 70, SWEDEN
SN 1654-6628
EI 1654-661X
J9 FOOD NUTR RES
JI Food Nutr. Res.
PY 2015
VL 59
AR 28886
DI 10.3402/fnr.v59.28886
PG 10
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA CY6LG
UT WOS:000366519900001
PM 26652604
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Alipour, A
   Rahimi, VB
   Askari, VR
AF Alipour, Alieh
   Rahimi, Vafa Baradaran
   Askari, Vahid Reza
TI Promising influences of gingerols against metabolic syndrome: A
   mechanistic review
SO BIOFACTORS
LA English
DT Review
DE atherosclerosis; diabetes; gingerol; hypertension; inflammation;
   metabolic syndrome; obesity
ID ZINGIBER-OFFICINALE; OXIDATIVE STRESS; GLUCOSE-UPTAKE; NITRIC-OXIDE; RAT
   MODEL; INSULIN; 6-GINGEROL; FAT; ATHEROSCLEROSIS; ADIPOGENESIS
AB Metabolic syndrome is an inflammatory disorder characterized by diabetes, obesity, atherosclerosis, and hypertension. Globally, this disease is increasing, especially in developed countries. Supposedly, herbal treatments for this disease likely have fewer adverse effects than chemical medications. Thus, they can be suitable options among the available chemical treatments. Ginger has been used as a spice and medicinal plant in traditional medicine and cooking. This herbal compound and its derivatives, such as 6-gingerol, have shown promising effects on various molecular aspects of metabolic syndrome. In this study, we reviewed and discussed the significant impacts of gingerol, a derivative of ginger, on metabolic syndrome through various mechanisms. The benefits of 6-gingerol include its effects on AMP-activated protein kinase (AMPK), which prevent diabetes, lipid regulating effect (peroxisome proliferator-activated receptors, PPARs), as well as its effects on enzymes and proteins preventing hyperlipidemia caused by a high-fat diet. In addition, 6-gingerol has anti-atherosclerosis and anti-hypertension effects through several molecular mechanisms. The current review will discuss various effects of 6-gingerol on molecular pathways involved in diabetes, obesity, atherosclerosis, and hypertension as characterizing features of metabolic syndrome and suggests that 6-gingerol can be a potential treatment agent for metabolic syndrome and shed light on a higher requirement for more pre-clinical and clinical investigations.
C1 [Alipour, Alieh] Mashhad Univ Med Sci, Sch Pharm, Dept Pharmacodynam & Toxicol, Mashhad, Razavi Khorasan, Iran.
   [Alipour, Alieh; Askari, Vahid Reza] Mashhad Univ Med Sci, Int UNESCO Ctr Hlth Related Basic Sci & Human Nut, Azadi Sy,Vakil Abad Highway, Mashhad 9177948564, Razavi Khorasan, Iran.
   [Rahimi, Vafa Baradaran] Mashhad Univ Med Sci, Fac Med, Dept Cardiovasc Dis, Mashhad, Razavi Khorasan, Iran.
   [Askari, Vahid Reza] Mashhad Univ Med Sci, Appl Biomed Res Ctr, Mashhad, Razavi Khorasan, Iran.
   [Askari, Vahid Reza] Mashhad Univ Med Sci, Pharmacol Res Ctr Med Plants, Mashhad, Razavi Khorasan, Iran.
C3 Mashhad University of Medical Sciences; Mashhad University of Medical
   Sciences; Mashhad University of Medical Sciences; Mashhad University of
   Medical Sciences; Mashhad University of Medical Sciences
RP Askari, VR (corresponding author), Mashhad Univ Med Sci, Int UNESCO Ctr Hlth Related Basic Sci & Human Nut, Azadi Sy,Vakil Abad Highway, Mashhad 9177948564, Razavi Khorasan, Iran.
EM askariv@mums.ac.ir
RI Askari, Vahid Reza/ABB-8991-2020; Baradaran Rahimi, Vafa/AAR-4523-2021
OI Baradaran Rahimi, Vafa/0000-0003-2320-5095; Askari, Vahid
   Reza/0000-0001-9268-6270
FU Mashhad University of Medical Sciences
FX Mashhad University of Medical Sciences
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NR 83
TC 17
Z9 17
U1 3
U2 23
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0951-6433
EI 1872-8081
J9 BIOFACTORS
JI Biofactors
PD SEP
PY 2022
VL 48
IS 5
BP 993
EP 1004
DI 10.1002/biof.1892
EA OCT 2022
PG 12
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 5H7MF
UT WOS:000863415400001
PM 36191294
DA 2025-06-11
ER

PT J
AU Park, SB
   Blumenthal, JA
   Lee, SY
   Georgiades, A
AF Park, Sat Byul
   Blumenthal, James A.
   Lee, Soon Young
   Georgiades, Anastasia
TI Association of Cortisol and the Metabolic Syndrome in Korean Men and
   Women
SO JOURNAL OF KOREAN MEDICAL SCIENCE
LA English
DT Article
DE Cortisol; Metabolic syndrome; Cardiovascular Disease Risk Factor; Body
   Mass Index
ID INSULIN-RESISTANCE; BODY-COMPOSITION; LIPASE ACTIVITY; CENTRAL OBESITY;
   GLUCOSE; STRESS; TISSUE; NEUROENDOCRINE; PATHOGENESIS; SECRETION
AB Obesity and the metabolic syndrome are closely related and have become increasingly prevalent in Korea. The cardiovascular disease (CVD) risk factors comprising the metabolic syndrome have previously been associated with increased hypothalamic-pituitary-adrenal axis (HPAA) activity, but the associations have not been extensively examined in non-Caucasian populations. The aim of the present study was to investigate the relationships between cortisol, adiposity and the metabolic syndrome in a Korean population. A total of 1,881 adults participated in the study between January 2001 and February 2008. Sociodemographic data were assessed by questionnaires. Body composition, clinic blood pressures as well as metabolic variables including glucose, insulin, and lipid profile were assessed and analyzed in relation to cortisol levels. Mean age of the participants was 58.7 +/- 10.8 yr. Higher levels of cortisol was associated with elevated blood pressure, fasting glucose and total cholesterol in men, and between cortisol and systolic blood pressure, fasting glucose and total cholesterol in women. There was an increased risk for the metabolic syndrome associated with higher cortisol levels in both men (P < 0.001) and women (P = 0.040) adjusting for age and body mass index. Higher cortisol levels are associated with several CVD risk factors and the metabolic syndrome, independent of overall of adiposity level, in Korean men and women.
C1 [Park, Sat Byul; Blumenthal, James A.; Georgiades, Anastasia] Duke Univ, Med Ctr, Dept Psychiat & Behav Sci, Durham, NC 27710 USA.
   [Park, Sat Byul] Ajou Univ, Sch Med, Dept Family Practice & Community Hlth, Suwon 441749, South Korea.
   [Lee, Soon Young] Ajou Univ, Sch Med, Dept Prevent Med, Suwon 441749, South Korea.
C3 Duke University; Ajou University; Ajou University
RP Georgiades, A (corresponding author), Duke Univ, Med Ctr, Dept Psychiat & Behav Sci, Box 3842, Durham, NC 27710 USA.
EM anastasia.georgiades@duke.edu
RI Lee, Sang-Jun/A-3892-2015
CR Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
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NR 30
TC 24
Z9 26
U1 0
U2 6
PU KOREAN ACAD MEDICAL SCIENCES
PI SEOUL
PA 302 75 DONG DU ICHON, DONG YONGSAN KU, SEOUL 140 031, SOUTH KOREA
SN 1011-8934
EI 1598-6357
J9 J KOREAN MED SCI
JI J. Korean Med. Sci.
PD JUL
PY 2011
VL 26
IS 7
BP 914
EP 918
DI 10.3346/jkms.2011.26.7.914
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 789NG
UT WOS:000292521600011
PM 21738345
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Salmio, A
   Rissanen, APE
   Kurkela, JLO
   Rottensteiner, M
   Seipäjärvi, S
   Juurakko, J
   Kujala, UM
   Laukkanen, JA
   Wikgren, J
AF Salmio, Anniina
   Rissanen, Antti-Pekka E.
   Kurkela, Jari L. O.
   Rottensteiner, Mirva
   Seipajarvi, Santtu
   Juurakko, Joona
   Kujala, Urho M.
   Laukkanen, Jari A.
   Wikgren, Jan
TI Cardiorespiratory fitness is linked with heart rate variability during
   stress in "at-risk" adults
SO JOURNAL OF SPORTS MEDICINE AND PHYSICAL FITNESS
LA English
DT Article
DE Autonomic nervous system; Exercise test; Polysomnography; Psychological
   stress; Psychological tests
ID POSITION STATEMENT; PHYSICAL-ACTIVITY; EXERCISE; SLEEP; RESPONSES;
   METAANALYSIS; TREADMILL; DISEASE; MEN; AGE
AB BACKGROUND: Physiological mechanisms explaining why cardiorespiratory fitness (CRF) predicts cardiovascular morbidity and mortality are incompletely understood. We examined if CRF modifies vagally mediated heart rate variability (HRV) during acute physical or psychosocial stress or night-time sleep in adults with cardiovascular risk factors.METHODS: Seventy-eight adults (age 56 years [IQR 50-60], 74% female, body mass index 28 kg/m2 [IQR 25-31]) with frequent cardiovas-cular risk factors participated in this cross-sectional study. They went through physical (treadmill cardiopulmonary exercise test [CPET]) and psychosocial (Trier Social Stress Test for Groups [TSST-G]) stress tests and night-time sleep monitoring (polysomnography). Heart rate (HR) and vagally mediated HRV (root mean square of successive differences between normal R-R intervals [RMSSD]) were recorded during the experiments and analyzed by taking account of potential confounders.RESULTS: CRF (peak O2 uptake) averaged 99% (range 78-126) in relation to reference data. From pre-rest to moderate intensities during CPET and throughout TSST-G, HR did not differ between participants with CRF below median (CRFlower) and CRF equal to or above median (CRF-higher), whereas CRFhigher had higher HRV than CRFlower, and CRF correlated positively with HRV in all participants. Meanwhile, CRF had no independent associations with HR or HRV levels during slow-wave sleep, the presence of metabolic syndrome was not associated with recorded HR or HRV levels, and single factors predicted HRV responsiveness independently only to limited extents.CONCLUSIONS: CRF is positively associated with prevailing vagally mediated HRV at everyday levels of physical and psychosocial stress in adults with cardiovascular risk factors.
C1 [Salmio, Anniina; Kurkela, Jari L. O.; Seipajarvi, Santtu; Juurakko, Joona; Wikgren, Jan] Univ Jyvaskyla, Ctr Interdisciplinary Brain Res, Dept Psychol, Jyvaskyla, Finland.
   [Rissanen, Antti-Pekka E.; Rottensteiner, Mirva; Laukkanen, Jari A.] Cent Finland Hlth Care Dist, Jyvaskyla, Finland.
   [Rissanen, Antti-Pekka E.] Univ Helsinki, Fac Med, Sports & Exercise Med, Helsinki, Finland.
   [Rissanen, Antti-Pekka E.] Fdn Sports & Exercise Med, HULA Helsinki Sports & Exercise Med Clin, Helsinki, Finland.
   [Rottensteiner, Mirva; Kujala, Urho M.] Univ Jyvaskyla, Fac Sport & Hlth Sci, Jyvaskyla, Finland.
   [Laukkanen, Jari A.] Univ Eastern Finland, Fac Hlth Sci, Inst Clin Med, Kuopio, Finland.
   [Rissanen, Antti-Pekka E.] Univ Helsinki, Fac Med, Sports & Exercise Med, Makelankatu 47, Helsinki 00550, Finland.
C3 University of Jyvaskyla; Central Finland Central Hospital; University of
   Helsinki; University of Jyvaskyla; University of Eastern Finland;
   University of Helsinki
RP Rissanen, APE (corresponding author), Univ Helsinki, Fac Med, Sports & Exercise Med, Makelankatu 47, Helsinki 00550, Finland.
EM antti-pekka.rissanen@helsinki.fi
RI Kurkela, Jari/MTB-2453-2025; Laukkanen, Jari/N-2196-2019; Kujala,
   Urho/AAP-2547-2020; Wikgren, Jan/C-9529-2013; Rissanen,
   Antti-Pekka/AAQ-3786-2021
OI Kurkela, Jari/0000-0002-4437-6347; Rissanen,
   Antti-Pekka/0000-0003-2415-3979; Juurakko, Joona/0000-0002-1171-6739
FU Business Finland [2697/31/2018]; Firstbeat Technologies Oy (Jyvaskyla,
   Finland)
FX Funding for this study was provided by Business Finland (grant
   2697/31/2018) and Firstbeat Technologies Oy (Jyvaskyla, Finland).
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NR 54
TC 0
Z9 0
U1 3
U2 8
PU EDIZIONI MINERVA MEDICA
PI TURIN
PA CORSO BRAMANTE 83-85 INT JOURNALS DEPT., 10126 TURIN, ITALY
SN 0022-4707
EI 1827-1928
J9 J SPORT MED PHYS FIT
JI J. Sports Med. Phys. Fit.
PD APR
PY 2024
VL 64
IS 4
BP 334
EP 347
DI 10.23736/S0022-4707.23.15373-4
EA JAN 2024
PG 14
WC Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Sport Sciences
GA RU0W7
UT WOS:001147769700001
PM 38213267
DA 2025-06-11
ER

PT J
AU Bergasa, NV
   Mehlman, J
   Bir, K
AF Bergasa, NV
   Mehlman, J
   Bir, K
TI Aerobic exercise: a potential therapeutic intervention for patients with
   liver disease
SO MEDICAL HYPOTHESES
LA English
DT Article
ID QUALITY-OF-LIFE; NONALCOHOLIC STEATOHEPATITIS NASH; ALL-CAUSE MORTALITY;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; BIOCHEMICAL MANIFESTATIONS;
   CORTISOL SECRETION; GLUCOSE-TOLERANCE; PHYSICAL-ACTIVITY; HEPATITIS-C
AB Fatigue is a symptom of liver disease. Indirect evidence suggests that this type of fatigue is centrally mediated. Non-alcoholic steatohepatitis (NASH), which may lead to cirrhosis, is associated with insulin resistance. An activated hypothalamic pituitary adrenal axis results in increased secretion of cortisol releasing hormone, cortisol and catecholamines. Prolonged exposure to high levels of cortisol is associated with insulin resistance, as exemplified by the metabolic syndrome. Accumulation in visceral. fat is an independent factor associated with insulin resistance. Central (visceral) fat is less sensitive to insulin than the rest of body fat and the central nervous system and not peripheral insulin, appears to regulate lipotysis in visceral. fat by, at least in part, adrenergic mechanisms. Aerobic training has documented beneficial effects on mental health and fatigue secondary to chronic illness. In addition, aerobic training increases insulin sensitivity. Thus, aerobic training may decrease fatigue in liver disease and improve NASH. (C) 2004 Elsevier Ltd. All rights reserved.
C1 Suny Downstate Med Ctr, Dept Med, Div Hepatol, Brooklyn, NY 11203 USA.
C3 State University of New York (SUNY) System; SUNY Downstate Health
   Sciences University
RP Suny Downstate Med Ctr, Dept Med, Div Hepatol, 450 Clarkson Ave,POB 50, Brooklyn, NY 11203 USA.
EM nora.bergasa@downstate.edu
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NR 74
TC 16
Z9 17
U1 0
U2 5
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0306-9877
EI 1532-2777
J9 MED HYPOTHESES
JI Med. Hypotheses
PY 2004
VL 62
IS 6
BP 935
EP 941
DI 10.1016/j.mehy.2003.12.041
PG 7
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 825FI
UT WOS:000221741000019
PM 15142652
DA 2025-06-11
ER

PT J
AU Churchward, MA
   Tchir, DR
   Todd, KG
AF Churchward, Matthew A.
   Tchir, Devan R.
   Todd, Kathryn G.
TI Microglial Function during Glucose Deprivation: Inflammatory and
   Neuropsychiatric Implications
SO MOLECULAR NEUROBIOLOGY
LA English
DT Article
DE Microglia; Ischemia; Inflammation; Depression; Hypoglycemia; Diabetes
ID MAJOR DEPRESSIVE DISORDER; COGNITIVE IMPAIRMENT; METABOLIC SYNDROME;
   STROKE MECHANISMS; BRAIN-INJURY; HEPATITIS-C; CELL-DEATH; ACTIVATION;
   ISCHEMIA; DISEASE
AB Inflammation is increasingly recognized as a contributor to the pathophysiology of neuropsychiatric disorders, including depression, anxiety disorders and autism, though the factors leading to contextually inappropriate or sustained inflammation in pathological conditions are yet to be elucidated. Microglia, as the key mediators of inflammation in the CNS, serve as likely candidates in initiating pathological inflammation and as an ideal point of therapeutic intervention. Glucose deprivation, as a component of the pathophysiology of ischemia or occurring transiently in diabetes, may serve to modify microglial function contributing to inflammatory injury. To this end, primary microglia were cultured from postnatal rat brain and subject to glucose deprivation in vitro. Microglia were characterized for their proliferation, phagocytic function and secretion of inflammatory factors, and tested for their capacity to respond to a potent inflammatory stimulus. In the absence of glucose, microglia remained capable of proliferation, phagocytosis and inflammatory activation and showed increased release of inflammatory factors after presentation of an inflammatory stimulus. Glucose-deprived microglia demonstrated increased phagocytic activity and decreased accumulation of lipids in lipid droplets over a 48-h timecourse, suggesting they may use scavenged lipids as a key alternate energy source during metabolic stress. In the present manuscript, we present novel findings that glucose deprivation may sensitize microglial release of inflammatory mediators and prime microglial functions for both survival and inflammatory roles, which may contribute to psychiatric comorbidities of ischemia, diabetes and/or metabolic disorder.
C1 [Churchward, Matthew A.; Tchir, Devan R.; Todd, Kathryn G.] Univ Alberta, Dept Psychiat, Neurochem Res Unit, 116th St & 85th Ave NW, Edmonton, AB T6G 2R3, Canada.
   [Todd, Kathryn G.] Univ Alberta, Neurosci & Mental Hlth Inst, Edmonton, AB T6G 2R3, Canada.
C3 University of Alberta; University of Alberta
RP Todd, KG (corresponding author), Univ Alberta, Dept Psychiat, Neurochem Res Unit, 116th St & 85th Ave NW, Edmonton, AB T6G 2R3, Canada.; Todd, KG (corresponding author), Univ Alberta, Neurosci & Mental Hlth Inst, Edmonton, AB T6G 2R3, Canada.
EM kgtodd@ualberta.ca
RI Churchward, Matthew/AAG-5046-2021
OI Tchir, Devan/0000-0002-3561-127X
FU Alberta Health Services; Davey Endowment for Brain Research; Alberta
   Innovates Health Solutions
FX The authors are grateful to Jocelyn Madeira for technical support; Sam
   Baskar Jesudasan, Kyle Koss, and Kam Dhami for helpful discussions and
   to Sara Kenawy for preliminary observations. KGT and MAC acknowledge
   funding support from the Alberta Health Services, the Davey Endowment
   for Brain Research, and fellowship support (MAC) from Alberta Innovates
   Health Solutions.
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NR 119
TC 48
Z9 50
U1 0
U2 17
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0893-7648
EI 1559-1182
J9 MOL NEUROBIOL
JI Mol. Neurobiol.
PD FEB
PY 2018
VL 55
IS 2
BP 1477
EP 1487
DI 10.1007/s12035-017-0422-9
PG 11
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA FW8YX
UT WOS:000425624000047
PM 28176274
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Sajjadi, SS
   Bagherniya, M
   Soleimani, D
   Siavash, M
   Askari, G
AF Sajjadi, Sana Sadat
   Bagherniya, Mohammad
   Soleimani, Davood
   Siavash, Mansour
   Askari, Gholamreza
TI Effect of propolis on mood, quality of life, and metabolic profiles in
   subjects with metabolic syndrome: a randomized clinical trial
SO SCIENTIFIC REPORTS
LA English
DT Article
ID TYPE-2 DIABETES-MELLITUS; STRESS SCALES DASS; INSULIN-RESISTANCE;
   GLYCEMIC CONTROL; DOUBLE-BLIND; OXIDATIVE STRESS; IN-VITRO; CHOLESTEROL;
   SUPPLEMENTATION; DEPRESSION
AB Metabolic syndrome (MeS) is a common multifaceted disorder. Plants contain antioxidant bioactive compounds, which are beneficial to improve the health condition of patients with MeS. Propolis is a hive natural product that is composed of various constituent. We aimed to assess the effects of Iranian propolis as a natural and safe agent on indicators of MeS, quality of life and mood status in individuals with MeS. In total, 66 interested eligible patients recruited to the present study. Participants were randomly assigned to consume a tablet at dose of 250 mg of propolis extract, twice daily for 12 weeks or placebo. Propolis supplementation could lead to a significant reduction in waist circumference (WC), increase in physical functioning, general health and the overall score of SF-36 compared with placebo group (P-value < 0.05). However, no significant differences were observed regarding other anthropometric indices and biochemical parameters between two groups (P-value > 0.05). The current study indicated that propolis can be effective in decreasing WC and improving physical health and quality of life, while had no significant effects on other components of MeS among subjects with this syndrome. Clinical trials registration Iran Registry of Clinical Trials.ir IRCT20121216011763N49, registration date 23/12/2020.
C1 [Sajjadi, Sana Sadat; Bagherniya, Mohammad; Askari, Gholamreza] Isfahan Univ Med Sci, Nutr & Food Secur Res Ctr, Sch Nutr & Food Sci, Dept Community Nutr, Esfahan, Iran.
   [Bagherniya, Mohammad; Askari, Gholamreza] Isfahan Univ Med Sci, Anesthesia & Crit Care Res Ctr, Esfahan, Iran.
   [Soleimani, Davood] Kermanshah Univ Med Sci, Res Ctr Oils & Fats, Kermanshah, Iran.
   [Soleimani, Davood] Kermanshah Univ Med Sci, Sch Nutr Sci & Food Technol, Nutr Sci Dept, Kermanshah, Iran.
   [Siavash, Mansour] Isfahan Univ Med Sci, Isfahan Endocrine & Metab Res Ctr, Esfahan, Iran.
C3 Isfahan University of Medical Sciences; Isfahan University of Medical
   Sciences; Kermanshah University of Medical Sciences; Kermanshah
   University of Medical Sciences; Isfahan University of Medical Sciences
RP Askari, G (corresponding author), Isfahan Univ Med Sci, Nutr & Food Secur Res Ctr, Sch Nutr & Food Sci, Dept Community Nutr, Esfahan, Iran.; Askari, G (corresponding author), Isfahan Univ Med Sci, Anesthesia & Crit Care Res Ctr, Esfahan, Iran.
EM askari@mui.ac.ir
RI askari, gholamreza/M-9362-2016; Siavash, Mansour/C-8151-2018
FU Isfahan University of Medical Sciences, Isfahan, Iran [199373]
FX This clinical trial is funded by Isfahan University of Medical Sciences,
   Isfahan, Iran (Grant number: 199373). This manuscript was obtained from
   the Master of Science thesis of Sana Sadat Sajjadi a student at Isfahan
   University of Medical Sciences. The funder has no role in designing the
   study, analyzing the data and interpreting, or writing the script.
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NR 78
TC 15
Z9 15
U1 1
U2 2
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD MAR 17
PY 2023
VL 13
IS 1
AR 4452
DI 10.1038/s41598-023-31254-y
PG 13
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA A5XD8
UT WOS:000955841200030
PM 36932147
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Jankovic, A
   Korac, A
   Buzadzic, B
   Otasevic, V
   Stancic, A
   Daiber, A
   Korac, B
AF Jankovic, Aleksandra
   Korac, Aleksandra
   Buzadzic, Biljana
   Otasevic, Vesna
   Stancic, Ana
   Daiber, Andreas
   Korac, Bato
TI Redox implications in adipose tissue (dys)function-A new look at old
   acquaintances
SO REDOX BIOLOGY
LA English
DT Review
DE Adipose tissue; Obesity; Insulin resistance; Redox
ID NITRIC-OXIDE SYNTHASE; INCREASED OXIDATIVE STRESS; ACTIVATED
   RECEPTOR-GAMMA; INSULIN-RESISTANCE; REACTIVE OXYGEN; MITOCHONDRIAL
   DYSFUNCTION; NADPH OXIDASE; IN-VIVO; NAD(P)H OXIDASE; GENE-EXPRESSION
AB Obesity is an energy balance disorder associated with dyslipidemia, insulin resistance and diabetes type 2, also summarized with the term metabolic syndrome or syndrome X. Increasing evidence points to "adipocyte dysfunction", rather than fat mass accretion per se, as the key pathophysiological factor for metabolic complications in obesity. The dysfunctional fat tissue in obesity characterizes a failure to safely store metabolic substrates into existing hypertrophied adipocytes and/or into new preadipocytes recruited for differentiation. In this review we briefly summarize the potential of redox imbalance in fat tissue as an instigator of adipocyte dysfunction in obesity. We reveal the challenge of the adipose redox changes, insights in the regulation of healthy expansion of adipose tissue and its reduction, leading to glucose and lipids overflow. (C) 2015 Published by Elsevier B.V.
C1 [Jankovic, Aleksandra; Buzadzic, Biljana; Otasevic, Vesna; Stancic, Ana; Korac, Bato] Univ Belgrade, Inst Biol Res Sinisa Stankovic, Dept Physiol, Belgrade 11060, Serbia.
   [Korac, Aleksandra] Univ Belgrade, Fac Biol, Ctr Electron Microscopy, Belgrade 11060, Serbia.
   [Daiber, Andreas] Univ Med Ctr, Dept Med 2, Mol Cardiol, Mainz, Germany.
C3 University of Belgrade; University of Belgrade; Johannes Gutenberg
   University of Mainz
RP Korac, B (corresponding author), Univ Belgrade, Inst Biol Res Sinisa Stankovic, Dept Physiol, Bulevar Despota Stefana 142, Belgrade 11060, Serbia.
EM koracb@ibiss.bg.ac.rs
RI Stancic, Ana/AAA-8051-2019; Daiber, Andreas/HJY-5274-2023; Korac,
   Bato/AAH-8206-2021; Jankovic, Aleksandra/ACV-5778-2022; Otasevic,
   Vesna/U-2242-2017
OI Jankovic, Aleksandra/0000-0002-6945-927X; Korac,
   Bato/0000-0001-5272-579X; Otasevic, Vesna/0000-0001-8660-8284; Stancic,
   Ana/0000-0003-0806-0799
FU Ministry of Science and Technological Development of Republic of Serbia
   [173055]; European Cooperation in Science and Technology (COST Action)
   [BM1203/EU-ROS]
FX This work was supported by the Ministry of Science and Technological
   Development of the Republic of Serbia, Grant 173055 and by the European
   Cooperation in Science and Technology (COST Action BM1203/EU-ROS).
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NR 196
TC 70
Z9 75
U1 0
U2 5
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 2213-2317
J9 REDOX BIOL
JI Redox Biol.
PD DEC
PY 2015
VL 6
BP 19
EP 32
DI 10.1016/j.redox.2015.06.018
PG 14
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA CZ8GR
UT WOS:000367338700003
PM 26177468
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Chiang, HI
   Lo, SC
   Beckstead, JW
   Yang, CY
AF Chiang, Hsing-, I
   Lo, Su-Chen
   Beckstead, Jason W.
   Yang, Chiu-Yueh
TI Effects of Baduanjin Qigong in Individuals With Schizophrenia A
   Preliminary Quasi-Experimental Pilot Study
SO JOURNAL OF PSYCHOSOCIAL NURSING AND MENTAL HEALTH SERVICES
LA English
DT Article
ID PHYSICAL-ACTIVITY; METABOLIC SYNDROME; ASSOCIATION; HEALTH; PEOPLE
AB The current quasi-experimental study explored the effects of Baduanjin qigong on body mass index (BMI) and five metabolic indexes in people with schizophrenia. Inclusion criteria were body mass index >25 kg/m(2) or metabolic syndrome. Twenty-two service users were recruited from a psychiatric center and were assigned to the experimental group (EG) or control group (CG) using blocked randomization. The EG performed Baduanjin qigong lasting 1 hour for 12 weeks three times per week, whereas the CG received routine care. Generalized estimating equations showed that the EG achieved a greater decrease in BMI and waist circumference (WC) than the CG post-intervention. Baduanjin qigong may provide an effective nonphar-macological approach to reducing BMI and WC in people with schizophrenia. This study showed that performing Baduanjin qigong for 12 weeks is a feasible and effective strategy for improving the body shape of individuals with chronic schizophrenia, thus providing results that can serve as a reference for health professionals working in psychiatry departments. [Journal of Psychosocial Nursing and Mental Health Services, xx(xx), xx-xx.]
C1 [Chiang, Hsing-, I] Chang Gung Mem Hosp, Sect Epilepsy, Dept Neurol, Linkou, Taiwan.
   [Lo, Su-Chen] Natl Taipei Univ Nursing & Hlth Sci, Sch Nursing, Taipei, Taiwan.
   [Yang, Chiu-Yueh] Natl Yang Ming Chiao Tung Univ, Coll Nursing, 155,Sec 2,Linong St, Taipei 11221, Taiwan.
   [Lo, Su-Chen] Minist Hlth & Welf, Dept Nursing, Bali Psychiat Ctr, New Taipei City, Taiwan.
   [Beckstead, Jason W.] Univ S Florida, Coll Publ Hlth, Tampa, FL USA.
   [Yang, Chiu-Yueh] Natl Yang Ming Chiao Tung Univ, Coll Nursing, 155 Sec 2 Linong St, Taipei 11221, Taiwan.
C3 Chang Gung Memorial Hospital; National Taipei University of Nursing &
   Health Science (NTUNHS); National Yang Ming Chiao Tung University; State
   University System of Florida; University of South Florida; National Yang
   Ming Chiao Tung University
RP Yang, CY (corresponding author), Natl Yang Ming Chiao Tung Univ, Coll Nursing, 155,Sec 2,Linong St, Taipei 11221, Taiwan.; Yang, CY (corresponding author), Natl Yang Ming Chiao Tung Univ, Coll Nursing, 155 Sec 2 Linong St, Taipei 11221, Taiwan.
EM cyyang530904@nycu.edu.tw
RI Chiang, Hsin-I/AAF-6578-2020; Lo, Su Chen/KIE-8099-2024; Yang,
   Chiu-Yueh/AEK-3524-2022
FU Yen Tjing Ling Medical Foundation [CI-103-27]
FX Support: This work was supported by grants from the Yen Tjing Ling
   Medical Foundation (CI-103-27) .
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NR 28
TC 0
Z9 0
U1 3
U2 11
PU SLACK INC
PI THOROFARE
PA 6900 GROVE RD, THOROFARE, NJ 08086 USA
SN 0279-3695
EI 1938-2413
J9 J PSYCHOSOC NURS MEN
JI J. Psychosoc. Nurs. Ment. Health Serv.
PD APR
PY 2024
VL 62
IS 4
DI 10.3928/02793695-20230920-01
EA SEP 2023
PG 9
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA NC7J1
UT WOS:001079176900001
PM 37751581
DA 2025-06-11
ER

PT J
AU Park, H
   Kim, UJ
   Choi, EJ
   Jun, SH
   Park, B
   Lee, HA
   Kim, HS
   Park, H
AF Park, Hyunjin
   Kim, Ui-Jeong
   Choi, Eun Jeong
   Jun, Seunghee
   Park, Bomi
   Lee, Hye Ah
   Kim, Hae Soon
   Park, Hyesook
TI The association between urinary cotinine level and metabolic syndrome
   profiles among adolescents: findings from the Ewha Birth and growth
   study
SO BMC PUBLIC HEALTH
LA English
DT Article
DE Cotinine; Secondhand smoke; Metabolic syndrome; Adolescents; Cohort
ID SECONDHAND SMOKE; PASSIVE SMOKING; RISK SCORE; EXPOSURE; DISEASE;
   NICOTINE; CHILDREN
AB Background:Secondhand smoke (SHS) exposure among adolescents who are still developing can negatively affect their physical and psychological health, including metabolic syndrome (MetS), which is a risk factor for cardiovascular disease. However, the relationship between exposure to SHS and MetS in adolescence has not been evaluated.Methods:A total of 240 subjects aged 13-15 years who were followed up in the Ewha Birth and Growth Study were included in this study. Using the urinary cotinine level, the participants' exposure to SHS was divided into tertiles, and the continuous MetS score (cMetS) and its components were compared among the three groups using a generalized linear model and trend analysis. Univariate and multivariate linear regression analyses were performed. We adjusted for several confounding variables including sex, father's education level, father's current alcohol consumption status, moderate physical activity, and overweight status.Results:The association between cMetS and the urinary cotinine level was not significant. However, the higher the urinary cotinine level, the lower the high-density lipoprotein cholesterol (HDL-C) level. In particular, the significance of the HDL-C level was maintained after adjusting for covariates.Conclusions:This study supports an association between SHS exposure and the components of MetS in adolescents aged 13-15 years, and it suggests the need to address SHS exposure in adolescents to reduce the cardiovascular risk in later life.
C1 [Park, Hyunjin; Kim, Ui-Jeong; Choi, Eun Jeong; Jun, Seunghee; Park, Hyesook] Ewha Womans Univ, Coll Med, Dept Prevent Med, 25 Magokdong ro,2 gil, Seoul 07804, South Korea.
   [Park, Hyunjin; Kim, Ui-Jeong; Jun, Seunghee; Park, Hyesook] Ewha Womans Univ, Grad Program Syst Hlth Sci & Engn, Seoul, South Korea.
   [Park, Bomi] Chung Ang Univ, Coll Med, Dept Prevent Med, Seoul, South Korea.
   [Lee, Hye Ah] Ewha Womans Univ, Mokdong Hosp, Clin Trial Ctr, Seoul, South Korea.
   [Kim, Hae Soon] Ewha Womans Univ, Coll Med, Dept Pediat, Seoul, South Korea.
C3 Ewha Womans University; Ewha Womans University; Chung Ang University;
   Chung Ang University Hospital; Ewha Womans University; Ewha Womans
   University
RP Park, H (corresponding author), Ewha Womans Univ, Coll Med, Dept Prevent Med, 25 Magokdong ro,2 gil, Seoul 07804, South Korea.; Park, H (corresponding author), Ewha Womans Univ, Grad Program Syst Hlth Sci & Engn, Seoul, South Korea.
EM hpark@ewha.ac.kr
RI Park, Hyun Jin/HSG-6465-2023; Lee, Hye Ah/ABC-8131-2021
OI Park, Bomi/0000-0001-5834-9975; Jun, Seunghee/0000-0002-0530-8720; Kim,
   Ui-Jeong/0000-0001-8362-2232; Park, Hyunjin/0000-0001-6536-8787; Park,
   Hyesook/0000-0002-9359-6522
FU Basic Science Research Program through the National Research Foundation
   of Korea (NRF) - Ministry of Education [NRF-2020R1F1A1062227]; BK21 FOUR
   (Fostering Outstanding Universities for Research) - Ministry of
   Education and National Research Foundation of Korea [NRF-5199990614253]
FX (1):This research was supported by Basic Science Research Program
   through the National Research Foundation of Korea (NRF) funded by the
   Ministry of Education (NRF-2020R1F1A1062227). (2):This research was
   supported by the BK21 FOUR (Fostering Outstanding Universities for
   Research) funded by the Ministry of Education and National Research
   Foundation of Korea (NRF-5199990614253).
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NR 51
TC 5
Z9 5
U1 0
U2 0
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2458
J9 BMC PUBLIC HEALTH
JI BMC Public Health
PD APR 21
PY 2023
VL 23
IS 1
AR 732
DI 10.1186/s12889-023-15458-5
PG 8
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA F6YL5
UT WOS:000983779600010
PM 37085791
OA gold
DA 2025-06-11
ER

PT J
AU Lange, SMM
   Schirmbeck, F
   Stek, ML
   Jansen, YRM
   van Rooijen, G
   de Haan, L
   Penninx, BWJH
   Rhebergen, D
AF Lange, Sjors M. M.
   Schirmbeck, Frederike
   Stek, Max L.
   Jansen, Yentl R. Murk
   Rooijen, Geeske van
   Haan, Lieuwe de
   Penninx, Brenda W. J. H.
   Rhebergen, Didi
CA GROUP Investigators
TI A comparison of depressive symptom profiles between current major
   depressive disorder and schizophrenia spectrum disorder
SO JOURNAL OF PSYCHIATRIC RESEARCH
LA English
DT Article
DE Schizophrenia; Depression; QIDS-SR; Symptom profile; Comorbidity;
   Depressive symptoms
ID QUALITY-OF-LIFE; SUBJECTIVE EXPERIENCE; RECEPTOR OCCUPANCY; METABOLIC
   SYNDROME; MECHANISMS; ANXIETY; RISK; PSYCHOPATHOLOGY; METAANALYSIS;
   ASSOCIATION
AB Introduction: Depressive symptoms are highly prevalent and clinically relevant in schizophrenia spectrum disorder (SSD) patients. So far, little is known about to what extent the depressive symptom profile in SSD is comparable to that seen in major depressive disorder (MDD).
   Methods: Data were derived from the Genetic Risk and Outcome of Psychosis study (GROUP) and the Netherlands Study of Depression and Anxiety (NESDA). We examined differences in severity of depressive symptom profiles and distribution of mood/cognition and somatic/vegetative depressive symptoms using the Quick Inventory of Depressive Symptomatology - Self Report (QIDS-SR) within SSD patients (n = 449), MDD patients (n = 816) and healthy controls (n = 417), aged 18 to 50. Within SSD, associations between depression severity and clinical and demographic data were examined.
   Results: 60.4% of SSD patients showed substantial depressive symptomatology (QIDS-SR >= 6). The difference in mood/cognition symptoms between SSD and MDD was larger (higher symptoms in MDD, effect size = 1.13), than the differences in somatic/vegetative symptoms (effect size 0.74). In patients with SSD, multivariable regression analyses showed that lower social functioning, male gender, use of benzodiazepine and more severe positive symptoms were associated with higher overall depressive symptomatology. The use of antipsychotics or anti-depressants was associated with more somatic/vegetative symptoms.
   Conclusion: More than half of SSD patients have considerable depressive symptomatology, with a relative preponderance of somatic/vegetative symptoms compared to the profile seen in MDD. Future research could explore whether depressive symptom profile in SSD may also be associated with biological dysregulations like in MDD.
C1 [Lange, Sjors M. M.; Stek, Max L.; Jansen, Yentl R. Murk; Penninx, Brenda W. J. H.; Rhebergen, Didi] Vrije Univ Amsterdam, Amsterdam UMC, Amsterdam Publ Hlth Res Inst, Amsterdam, Netherlands.
   [Lange, Sjors M. M.; Stek, Max L.; Jansen, Yentl R. Murk; Penninx, Brenda W. J. H.; Rhebergen, Didi] GGZ InGeest, Oldenaller 1, NL-1081 HJ Amsterdam, Netherlands.
   [Schirmbeck, Frederike; Rooijen, Geeske van; Haan, Lieuwe de] Univ Amsterdam, Amsterdam UMC, Dept Psychiat, Amsterdam, Netherlands.
   [Schirmbeck, Frederike; Haan, Lieuwe de] Arkin Inst Mental Hlth, Amsterdam, Netherlands.
C3 Vrije Universiteit Amsterdam; University of Amsterdam; Vrije
   Universiteit Amsterdam; University of Amsterdam
RP Lange, SMM (corresponding author), GGZ InGeest, Oldenaller 1, NL-1081 HJ Amsterdam, Netherlands.
EM s.lange@ggzingeest.nl
RI Schirmbeck, Frederike/G-8187-2016; Penninx, Brenda/S-7627-2017
OI Schirmbeck, Frederike/0000-0003-1700-0958; Simons,
   Claudia/0000-0002-7637-3589; Lange, Sjors/0000-0002-3843-9372
FU Dutch Health Research Council (Zon-Mw) [10-000-1001]; Lundbeck;
   AstraZeneca; Eli Lilly; Janssen Cilag
FX The infrastructure for the GROUP study is funded through the Geestkracht
   programme of the Dutch Health Research Council (Zon-Mw, grant number
   10-000-1001), and matching funds from participating pharmaceutical
   companies (Lundbeck, AstraZeneca, Eli Lilly, Janssen Cilag) and
   universities and mental health care organizations (Amsterdam: Academic
   Psychiatric Centre of the Academic Medical Center and the mental health
   institutions: GGZ Ingeest, Arkin, Dijk en Duin, GGZ Rivierduinen,
   Erasmus Medical Centre, GGZ Noord Holland Noord. Groningen: University
   Medical Center Groningen and the mental health institutions: Lentis, GGZ
   Friesland, GGZ Drenthe, Dimence, Mediant, GGNet Warnsveld, Yulius
   Dordrecht and Parnassia psycho-medical center The Hague. Maastricht:
   Maastricht University Medical Centre and the mental health institutions:
   GGzE, GGZ Breburg, GGZ OostBrabant, Vincent van Gogh voor Geestelijke
   Gezondheid, Mondriaan, Virenze riagg, Zuyderland GGZ, MET ggz,
   Universitair Centrum SintJozef Kortenberg, CAPRI University of Antwerp,
   PC Ziekeren SintTruiden, PZ Sancta Maria Sint-Truiden, GGZ Overpelt, OPZ
   Rekem. Utrecht: University Medical Center Utrecht and the mental health
   institutions Altrecht, GGZ Centraal and Delta.)
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NR 71
TC 8
Z9 8
U1 1
U2 21
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-3956
EI 1879-1379
J9 J PSYCHIATR RES
JI J. Psychiatr. Res.
PD MAR
PY 2021
VL 135
BP 143
EP 151
DI 10.1016/j.jpsychires.2021.01.009
EA JAN 2021
PG 9
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA QL9UK
UT WOS:000621425700019
PM 33486162
OA Green Published
DA 2025-06-11
ER

PT J
AU Stanley, SH
   Laugharne, JDE
AF Stanley, Susanne H.
   Laugharne, Jonathan D. E.
TI Obesity, cardiovascular disease and type 2 diabetes in people with a
   mental illness: a need for primary health care
SO AUSTRALIAN JOURNAL OF PRIMARY HEALTH
LA English
DT Article
DE physical health
ID CORONARY-HEART-DISEASE; INDUCED WEIGHT-GAIN; METABOLIC SYNDROME;
   ANTIPSYCHOTIC MEDICATION; PSYCHIATRIC-PATIENTS; INSULIN SENSITIVITY;
   GLUCOSE-TOLERANCE; RISK; SCHIZOPHRENIA; DISORDERS
AB People with a mental illness show a growing incidence of obesity, and higher rates of metabolic syndrome when compared with the general population. This paper reviews research on obesity, cardiovascular disease and type 2 diabetes, with the aim of directing clinical attention towards the improvement of patient physical health. A systematic search of cross-discipline databases and journals provided peer-reviewed research for analysis, and national statistics allowed for the investigation of differences in rates of occurrence between people experiencing a mental illness and the general population. Treatment effects via psychotropic medications and lifestyle factors such as poor diet and low levels of exercise suggest that ongoing monitoring is necessary to prevent major physical disorders in people experiencing a mental illness. To aid clinicians, a comprehensive set of clinical guidelines have been developed for the physical assessment and ongoing monitoring of mental health patients.
C1 [Stanley, Susanne H.; Laugharne, Jonathan D. E.] Univ Western Australia, Fremantle Hosp, Community Culture & Mental Hlth Unit, Sch Psychiat & Clin Neurosci, Fremantle, WA 6160, Australia.
C3 University of Western Australia; South Metropolitan Health Service;
   Fiona Stanley Fremantle Hospitals Group; Fremantle Hospital
RP Stanley, SH (corresponding author), Univ Western Australia, Fremantle Hosp, Community Culture & Mental Hlth Unit, Sch Psychiat & Clin Neurosci, W Block,L6,1 Alma St, Fremantle, WA 6160, Australia.
EM susanne.stanley@uwa.edu.au
RI Stanley, Susanne/H-5882-2014
OI Stanley, Susanne/0000-0002-0404-9018
FU Mental Health Commission, Government of Western Australia
FX This literature search was partially funded by the Mental Health
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NR 62
TC 27
Z9 33
U1 0
U2 15
PU CSIRO PUBLISHING
PI COLLINGWOOD
PA 150 OXFORD ST, PO BOX 1139, COLLINGWOOD, VICTORIA 3066, AUSTRALIA
SN 1448-7527
J9 AUST J PRIM HEALTH
JI Aust. J. Prim. Health.
PY 2012
VL 18
IS 3
BP 258
EP 264
DI 10.1071/PY11045
PG 7
WC Health Care Sciences & Services; Health Policy & Services; Primary
   Health Care; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services; General & Internal Medicine; Public,
   Environmental & Occupational Health
GA 984WR
UT WOS:000307224100013
PM 23069370
DA 2025-06-11
ER

PT J
AU Happell, B
   Wilson, K
   Platania-Phung, C
   Stanton, R
AF Happell, Brenda
   Wilson, Karen
   Platania-Phung, Chris
   Stanton, Robert
TI Physical health nurse consultant role to improve physical health in
   mental health services: A carer's perspective
SO INTERNATIONAL JOURNAL OF MENTAL HEALTH NURSING
LA English
DT Article
DE carers; communication; mental health; mental illness; nursing; physical
   health
ID METABOLIC SYNDROME; LIFE EXPECTANCY; ILLNESS; PEOPLE; CONSUMERS; FAMILY;
   RECOMMENDATIONS; SCHIZOPHRENIA; CONCEPTIONS; PREVALENCE
AB The physical health of people diagnosed with a mental illness is significantly poorer in comparison with the general population. Awareness of this health disparity is increasing; however, strategies to address the problem are limited. Carers play an important role in the physical health care of people with mental illness, particularly in facilitating navigation of and advocating in the health care system. A specialist physical health nurse consultant position has been suggested as a way to address the physical health care disparity and limited research available suggests that positive outcomes are possible. In the present study, a qualitative exploratory research project was undertaken, involving in-depth interviews with people identifying as mental health carers. Two focus groups and one individual interview were conducted involving a total of 13 carers. The resulting data were analyzed thematically. Views and opinions about the proposed physical health nurse consultant (PHNC) position were sought during these interviews and are reported in this paper. Two main sub-themes were evident relating to characteristics of this role: reliability and consistency; and communication and support. Essentially carers expressed a need for support for themselves and consumers in addressing physical health concerns. Successful implementation of this position would require a consistent and reliable approach. Carers are significant stakeholders in the physical health of consumers of mental health services and their active involvement in identifying and tailoring services, including development of the physical health nurse consultant must be seen as a priority.
C1 [Happell, Brenda; Wilson, Karen; Platania-Phung, Chris] Univ Canberra, Fac Hlth, Synergy Nursing & Midwifery Res Ctr, Bldg 6,Level 3,POB 11, Woden, ACT 2606, Australia.
   [Happell, Brenda; Wilson, Karen; Platania-Phung, Chris] ACT Hlth, Woden, ACT, Australia.
   [Stanton, Robert] Cent Queensland Univ, Sch Med & Appl Sci, Rockhampton, Qld 4702, Australia.
C3 University of Canberra; ACT Health Australia; Central Queensland
   University
RP Happell, B (corresponding author), Univ Canberra, Fac Hlth, Synergy Nursing & Midwifery Res Ctr, Bldg 6,Level 3,POB 11, Woden, ACT 2606, Australia.; Happell, B (corresponding author), ACT Hlth, Canberra Hosp, Bldg 6,Level 3,POB 11, Woden, ACT 2606, Australia.
EM brenda.happell@canberra.edu.au
RI Stanton, Rob/AAJ-5157-2020; Happell, Brenda/HSI-0570-2023
OI Happell, Brenda/0000-0002-7293-6583
FU Mental Health Branch, ACT
FX The research team extend our sincere thanks to Carers ACT for
   facilitating this research through access to participants, organizing
   the focus groups, providing the venue catering and for co-funding this
   important work in collaboration with the Mental Health Branch, ACT.
   Thanks so much to the participants for your generosity and openness in
   sharing your views and experiences.
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NR 58
TC 11
Z9 12
U1 3
U2 19
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1445-8330
EI 1447-0349
J9 INT J MENT HEALTH NU
JI Int. J. Ment. Health Nurs.
PD JUN
PY 2016
VL 25
IS 3
BP 243
EP 250
DI 10.1111/inm.12208
PG 8
WC Nursing; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Psychiatry
GA DN5LM
UT WOS:000377109400008
PM 26876094
DA 2025-06-11
ER

PT J
AU Kaski, JC
AF Kaski, JC
TI Cardiac syndrome X in women: the role of oestrogen deficiency
SO HEART
LA English
DT Article
ID NORMAL CORONARY ANGIOGRAMS; ELECTRICAL NERVE-STIMULATION; CARDIOLOGICAL
   SYNDROME-X; ST SEGMENT DEPRESSION; CHEST-PAIN; ANGINA-PECTORIS;
   POSTMENOPAUSAL WOMEN; MYOCARDIAL-ISCHEMIA; REVERSE REDISTRIBUTION;
   RESISTANCE VESSELS
AB Cardiac syndrome X (CSX), defined as typical exertional chest pain, a positive response to stress testing, and normal coronary arteriograms, encompasses different pathogenic subgroups. Both cardiac and non-cardiac mechanisms have been suggested to play a pathogenic role, and it has been shown that the syndrome is associated with myocardial ischaemia in at least a proportion of patients. Radionuclide myocardial perfusion defects, coronary sinus oxygen saturation abnormalities and pH changes, myocardial lactate production and stress-induced alterations of cardiac high energy phosphate have been reported in CSX patients, suggesting an ischaemic origin for their symptoms. Microvascular abnormalities often caused by endothelial dysfunction appear to be responsible for myocardial ischaemia in these patients. CSX is more prevalent in women than in men, and the majority of women with CSX are peri- or post-menopausal. Thus oestrogen deficiency has been suggested to have a pathogenic role in CSX. Additional factors such as abnormal pain perception may also contribute to the genesis of chest pain in patients with angina and normal coronary angiograms. The management of this syndrome is difficult because of the heterogeneity of pathogenic mechanisms and uncertainties as to its origin. This article discusses the problem of CSX in women, the potential pathogenic role of oestrogen deficiency, and practical clinical management.
C1 Univ London St Georges Hosp, Sch Med, Cardiovasc Res Ctr, Div Cardiac & Vasc Sci, London SW17 0RE, England.
C3 City St Georges, University of London; St Georges University London
RP Kaski, JC (corresponding author), Univ London St Georges Hosp, Sch Med, Cardiovasc Res Ctr, Div Cardiac & Vasc Sci, Cranmer Terrace, London SW17 0RE, England.
EM jkaski@sghms.ac.uk
RI Kaski, Juan Carlos/LKM-8031-2024
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NR 52
TC 54
Z9 63
U1 0
U2 2
PU B M J PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 1355-6037
J9 HEART
JI Heart
PD MAY
PY 2006
VL 92
SU 3
BP 5
EP 9
DI 10.1136/hrt.2005.070318
PG 5
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 037EW
UT WOS:000237130500003
PM 16614266
OA Green Published
DA 2025-06-11
ER

PT J
AU Badoud, F
   Perreault, M
   Zulyniak, MA
   Mutch, DM
AF Badoud, Flavia
   Perreault, Maude
   Zulyniak, Michael A.
   Mutch, David M.
TI Molecular insights into the role of white adipose tissue in
   metabolically unhealthy normal weight and metabolically healthy obese
   individuals
SO FASEB JOURNAL
LA English
DT Review
DE cardiometabolic risk; obesity; biomarkers
ID BODY-MASS INDEX; INSULIN-RESISTANCE; URIC-ACID; POSTMENOPAUSAL WOMEN;
   CARDIOVASCULAR-DISEASE; OXIDATIVE STRESS; VISCERAL FAT; DIFFERENTIATES
   OBESE; ADIPOKINE PROFILE; GENE-EXPRESSION
AB Obesity is a risk factor for the development of type 2 diabetes and cardiovascular disease. However, it is now recognized that a subset of individuals have reduced cardiometabolic risk despite being obese. Paradoxically, a subset of lean individuals is reported to have high risk for cardiometabolic complications. These distinct subgroups of individuals are referred to as metabolically unhealthy normal weight (MUNW) and metabolically healthy obese (MHO). Although the clinical relevance of these subgroups remains debated, evidence shows a critical role for white adipose tissue (WAT) function in the development of these phenotypes. The goal of this review is to provide an overview of our current state of knowledge regarding the molecular and metabolic characteristics of WAT associated with MUNW and MHO. In particular, we discuss the link between different WAT depots, immune cell infiltration, and adipokine production with MUNW and MHO. Furthermore, we also highlight recent molecular insights made with genomic technologies showing that processes such as oxidative phosphorylation, branched-chain amino acid catabolism, and fatty acid beta-oxidation differ between these phenotypes. This review provides evidence that WAT function is closely linked with cardiometabolic risk independent of obesity and thus contributes to the development of MUNW and MHO.
C1 [Badoud, Flavia; Perreault, Maude; Zulyniak, Michael A.; Mutch, David M.] Univ Guelph, Dept Human Hlth & Nutr Sci, Guelph, ON N1G 2W1, Canada.
C3 University of Guelph
RP Mutch, DM (corresponding author), Univ Guelph, Dept Human Hlth & Nutr Sci, Guelph, ON N1G 2W1, Canada.
EM dmutch@uoguelph.ca
RI Zulyniak, Michael/ITT-9326-2023
OI Mutch, David/0000-0002-0908-7259; Zulyniak, Michael/0000-0003-4944-5521
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NR 106
TC 92
Z9 95
U1 2
U2 22
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0892-6638
EI 1530-6860
J9 FASEB J
JI Faseb J.
PD MAR
PY 2015
VL 29
IS 3
BP 748
EP 758
DI 10.1096/fj.14-263913
PG 11
WC Biochemistry & Molecular Biology; Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA CC8QK
UT WOS:000350633000003
PM 25411437
DA 2025-06-11
ER

PT J
AU Garcez, A
   Weiderpass, E
   Canuto, R
   Lecke, SB
   Spritzer, PM
   Pattussi, MP
   Olinto, MTA
AF Garcez, Anderson
   Weiderpass, Elisabete
   Canuto, Raquel
   Lecke, Sheila Bunecker
   Spritzer, Poli Mara
   Pattussi, Marcos Pascoal
   Anselmo Olinto, Maria Teresa
TI Salivary Cortisol, Perceived Stress, and Metabolic Syndrome: A Matched
   Case-Control Study in Female Shift Workers
SO HORMONE AND METABOLIC RESEARCH
LA English
DT Article
DE cortisol; saliva; perceived stress; metabolic syndrome; women; shift
   work
ID DISEASE; WOMEN; SCALE; RISK; ASSOCIATIONS; METAANALYSIS; OBESITY;
   HEALTH; SLEEP
AB Although the pathogenesis of metabolic syndrome (MetS) is complex and multifactorial, there is limited information if psychological factors, such as stress exposure, are involved in the etiology of MetS. Therefore, this study investigated the associations between MetS and cortisol levels and perceived stress levels among women shift workers in Southern Brazil. A matched case-control study was conducted, including 50 cases of MetS and 200 age-matched controls (+/- 3 years, 4 for each case). Salivary cortisol levels were evaluated immediately after waking and one upon returning home from work. Perceived stress levels were measured by the Perceived Stress Scale with 10 items (PSS-10). Multivariate-adjusted associations between MetS and salivary cortisol levels and perceived stress levels were assessed by conditional logistic regression. Means +/- standard deviations of salivary cortisol levels were not significantly different between cases and controls either immediately after waking (5.37 +/- 4.10 vs. 6.03 +/- 5.39 nmol/l; p = 0.53) or after work (2.74 +/- 2.87 vs. 2.78 +/- 2.85 nmol/l; p = 0.93). There was no significant difference in perceived stress level between cases and controls (14.2 +/- 5.9 vs. 15.5 +/- 5.6; p = 0.15). No independent association was observed in the multivariate model between MetS and salivary cortisol level or perceived stress level after these exposures were stratified into tertiles. Overall, there was no difference between women with or without MetS in regard to the free salivary cortisol and perceived stress. Our results do not support an association between stress exposure and MetS among women shift workers.
C1 [Garcez, Anderson; Pattussi, Marcos Pascoal; Anselmo Olinto, Maria Teresa] Univ Vale Rio dos Sinos UNISINOS, Postgrad Program Collect Hlth, Av Unisinos, Sao Leopoldo, RS, Brazil.
   [Weiderpass, Elisabete] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.
   [Weiderpass, Elisabete] Canc Registry Norway, Dept Res, Inst Populat Based Canc Res, Oslo, Norway.
   [Weiderpass, Elisabete] Univ Tromso, Dept Community Med, Fac Hlth Sci, Tromso, Norway.
   [Weiderpass, Elisabete] Arctic Univ Norway, Univ Tromso, Tromso, Norway.
   [Weiderpass, Elisabete] Folkhalsan Res Ctr, Genet Epidemiol Grp, Helsinki, Finland.
   [Canuto, Raquel] Fed Univ Rio Grande do Sul State UFRGS, Dept Nutr, St Ramiro Barcelos, Porto Alegre, RS, Brazil.
   [Lecke, Sheila Bunecker; Spritzer, Poli Mara] HCPA, Gynecol Endocrinol Unit, Div Endocrinol, Porto Alegre, RS, Brazil.
   [Lecke, Sheila Bunecker] Fed Univ Hlth Sci Porto Alegre UFCSPA, Dept Diagnost Methods, St Sarmento Leite, Porto Alegre, RS, Brazil.
   [Spritzer, Poli Mara] Fed Univ Rio Grande do Sul State UFRGS, Lab Mol Endocrinol, Porto Alegre, RS, Brazil.
   [Spritzer, Poli Mara] Fed Univ Rio Grande do Sul State UFRGS, Dept Physiol, Porto Alegre, RS, Brazil.
   [Anselmo Olinto, Maria Teresa] Fed Univ Hlth Sci Porto Alegre UFCSPA, Dept Nutr, Porto Alegre, RS, Brazil.
C3 Universidade do Vale do Rio dos Sinos (Unisinos); Karolinska Institutet;
   University of Oslo; UiT The Arctic University of Tromso; UiT The Arctic
   University of Tromso; Folkhalsan Research Center; Universidade Federal
   do Rio Grande do Sul; Universidade Federal de Ciencias da Saude de Porto
   Alegre; Universidade Federal do Rio Grande do Sul; Universidade Federal
   do Rio Grande do Sul; Universidade Federal de Ciencias da Saude de Porto
   Alegre
RP Olinto, MTA (corresponding author), Univ Vale Rio dos Sinos, Postgrad Program Collect Hlth, Av Unisinos 950,CP 275, BR-93022000 Sao Leopoldo, RS, Brazil.
EM mtolinto@gmail.com
RI Canuto, Raquel/AAV-8688-2020; Spritzer, Poli/A-3357-2019; Bünecker
   Lecke, Sheila/HRC-8340-2023; Olinto, Maria/AAH-5897-2021; Garcez,
   Anderson/AAH-5877-2021; Pattussi, Marcos/P-1730-2019; Weiderpass,
   Elisabete/M-4029-2016; Pattussi, Marcos Pascoal/P-7580-2014
OI Weiderpass, Elisabete/0000-0003-2237-0128; Bunecker Lecke,
   Sheila/0009-0007-9073-5092; Spritzer, Poli Mara/0000-0002-5204-107X;
   Pattussi, Marcos Pascoal/0000-0003-2947-4229
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NR 38
TC 11
Z9 14
U1 0
U2 11
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0018-5043
EI 1439-4286
J9 HORM METAB RES
JI Horm. Metab. Res.
PD JUL
PY 2017
VL 49
IS 7
BP 510
EP 519
DI 10.1055/s-0043-101822
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism
GA FA0BG
UT WOS:000405095200005
PM 28561183
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Rezania, K
   Soliven, B
   Rezai, KA
   Roos, RP
AF Rezania, Kourosh
   Soliven, Betty
   Rezai, Kourous A.
   Roos, Raymond P.
TI Impaired glucose tolerance and metabolic syndrome in idiopathic
   polyneuropathy: The role of pain and depression
SO MEDICAL HYPOTHESES
LA English
DT Article
ID URINARY ALBUMIN EXCRETION; INSULIN-RESISTANCE; SUBCLINICAL INFLAMMATION;
   PERIPHERAL NEUROPATHY; CHRONIC COMPLICATIONS; INCREASED PREVALENCE;
   ABDOMINAL OBESITY; PLASMA-GLUCOSE; RISK-FACTORS; POPULATION
AB Chronic idiopathic axonal polyneuropathy (CIAP) is referred to as axonal neuropathy after an adequate workup fails to determine a cause. A subgroup of patients with CIAP has impaired glucose tolerance (IGT). These patients have been considered by some investigators to have a neuropathy as a result of IGT and/or metabolic syndrome (MetS). Patients with CIAP usually suffer from chronic pain and associated depression, both of which have been proposed to cause insulin resistance (IR) by such mechanisms as a sustained increase in the corticosteroids and catecholamines, and chronic low grade inflammation. In a pilot study of 14 patients with CIAP + IGT and eight normal controls, we found a correlation between the number of features of the MetS with scores of pain and depression. There was no increase in the frequency of retinopathy and nephropathy in these patients, contrary to what would have been expected if chronic hyperglycemia was the cause of the neuropathy. We hypothesize that neuropathy has an unclear cause in the majority of patients with CIAP + IGT/MetS - and IGT/MetS are a result of comorbidities of CIAP, including chronic pain and depression. (C) 2010 Elsevier Ltd. All rights reserved.
C1 [Rezania, Kourosh; Soliven, Betty; Roos, Raymond P.] Univ Chicago, Med Ctr, Dept Neurol, Chicago, IL 60637 USA.
   [Rezai, Kourous A.] Rush Univ, Dept Ophthalmol, Med Ctr, Chicago, IL 60612 USA.
C3 University of Chicago; University of Chicago Medical Center; Rush
   University
RP Rezania, K (corresponding author), Univ Chicago, Med Ctr, Dept Neurol, 5841 S Maryland Ave,MC 2030, Chicago, IL 60637 USA.
EM krezania@neurology.bsd.uchicago.edu
FU Brain Research Foundation; Jack Miller Neuropathy Center, University of
   Chicago; Jack Miller Neuropathy Center
FX A grant from the Brain Research Foundation and the Jack Miller
   Neuropathy Center, University of Chicago.This project was supported by a
   grant from the Brain Research Foundation and by funding from the Jack
   Miller Neuropathy Center. We are grateful to Dr. Louis Philipson for his
   advice and assistance, and to Dr. Mindy Drum for help with the
   statistical analysis of this study.
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NR 49
TC 5
Z9 8
U1 0
U2 2
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0306-9877
EI 1532-2777
J9 MED HYPOTHESES
JI Med. Hypotheses
PD APR
PY 2011
VL 76
IS 4
BP 538
EP 542
DI 10.1016/j.mehy.2010.12.012
PG 5
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 742FK
UT WOS:000288926500023
PM 21255940
DA 2025-06-11
ER

PT J
AU Zhang, M
   Tanenbaum, HC
   Felicitas-Perkins, JQ
   Pang, ZC
   Palmer, PH
   Duan, HP
   Johnson, CA
   Xie, B
AF Zhang, Meiwen
   Tanenbaum, Hilary C.
   Felicitas-Perkins, Jamie Q.
   Pang, Zengchang
   Palmer, Paula H.
   Duan, Haiping
   Johnson, C. Anderson
   Xie, Bin
TI Associations between psychological characteristics and indicators of
   metabolic syndrome among Chinese adults
SO PSYCHOLOGY HEALTH & MEDICINE
LA English
DT Article
DE Life satisfaction; hostility; depression; metabolic syndrome
ID CORONARY-HEART-DISEASE; BODY-MASS INDEX; YOUNG-ADULTS;
   CARDIOVASCULAR-DISEASE; DEPRESSIVE SYMPTOMS; WAIST CIRCUMFERENCE;
   HEALTH; LIFE; RISK; SATISFACTION
AB Current knowledge about the relationship between psychological characteristics and metabolic syndrome (MetS) components is limited in Asian populations. The purpose of this study is to investigate linkages between physiological markers of MetS and life satisfaction, hostility, and depression in Chinese adults. Secondary analyses were conducted using cross-sectional data from parents of randomly selected middle school students participating in a pilot study in Qingdao, China. Among 440 parents who consented to participate (237 women, 203 men), 368 provided valid responses in all three categories of psychological characteristics, and only those subjects were included in these analyses. General linear models and logistic regressions were run separately by gender, controlling for covariates. Among women, life satisfaction was inversely associated with triglyceride levels (p=.04), LDL-C (p<.01), risk of hypertriglyceridemia (OR[.53], p<.01), HDL-C (OR[.78], p=.03), and MetS (OR[.52], p=.03). No associations were found between life satisfaction and any psychological characteristics among men. Among women, hostility was positively associated with triglyceride level (p=.04) and risk of hypertriglyceridemia (OR[2.12], p<.05). Among men, hostility was positively associated with waist circumference (p=.04), waist-hip ratio (p<.05), and fasting plasma insulin (p<.01). Depression was not associated with any physiological measurement in either gender. These findings indicate that relationships exist between certain psychological characteristics and physiological indicators of MetS among Chinese adults, although there may be important differences between genders.
C1 [Zhang, Meiwen; Tanenbaum, Hilary C.; Felicitas-Perkins, Jamie Q.; Palmer, Paula H.; Johnson, C. Anderson; Xie, Bin] Claremont Grad Univ, Sch Community & Global Hlth, Claremont, CA USA.
   [Pang, Zengchang; Duan, Haiping] Qingdao Municipal Ctr Dis Control & Prevent, Qingdao, Peoples R China.
   [Johnson, C. Anderson] Community Translat Res Inst, Riverside, CA USA.
C3 Claremont Colleges; Claremont Graduate University
RP Zhang, M; Tanenbaum, HC; Xie, B (corresponding author), Claremont Grad Univ, Sch Community & Global Hlth, Claremont, CA USA.
EM meiwen.zhang@cgu.edu
RI Tanenbaum, Hilary/ABC-2755-2020; johnson, carl/JKI-1082-2023
OI Tanenbaum, Hilary/0000-0003-2282-1662
FU Claremont Graduate University/University of Southern California
   Transdisciplinary Tobacco Use Research Center (TTURC); National
   Institutes of Health [2 P50 CA084735-06]; R. Garfield Endowment;  [1 R03
   CA172985-01]
FX This research was supported by the Claremont Graduate
   University/University of Southern California Transdisciplinary Tobacco
   Use Research Center (TTURC), funded by the National Institutes of Health
   [grant number 2 P50 CA084735-06, Johnson C.A. as PI]; and the Sidney R.
   Garfield Endowment. Manuscript preparation was also partially
   grant-supported [grant number 1 R03 CA172985-01, Xie B. as PI].
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NR 38
TC 6
Z9 7
U1 0
U2 4
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 1354-8506
EI 1465-3966
J9 PSYCHOL HEALTH MED
JI Psychol. Health Med.
PY 2017
VL 22
IS 3
BP 359
EP 369
DI 10.1080/13548506.2016.1191657
PG 11
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA EK4BI
UT WOS:000393871700013
PM 27257718
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Cote, AT
   Devlin, AM
   Panagiotopoulos, C
AF Cote, Anita T.
   Devlin, Angela M.
   Panagiotopoulos, Constadina
TI Initial Screening of Children Treated With Second-Generation
   Antipsychotics Points to an Association Between Physical Activity and
   Insulin Resistance
SO PEDIATRIC EXERCISE SCIENCE
LA English
DT Article
DE HOMA-IR; mental health condition; obesity; exercise
ID METABOLIC SYNDROME; CHILDHOOD OBESITY; MODEL ASSESSMENT; MENTAL-HEALTH;
   GLUCOSE; PREVALENCE; EXERCISE; ADOLESCENTS; SENSITIVITY; TRENDS
AB Second-generation antipsychotic (SGA) medications, used to treat youth for a wide-range of mental health conditions, are associated with excessive weight gain and other comorbidities, placing these individuals at high risk for cardiovascular disease. Little is known about the effect of physical activity (PA) on cardiovascular risk in these children. Anthropometrics, fasting blood sample and self-report PA were obtained in 386 children diagnosed with mental health conditions (6-18 y). PA was classified as below (< 60 min/day) or meets (>= 60 min/day) current recommended guidelines for daily PA in children. SGA-treated (n = 166) and SGA-naive (n = 220) were compared in the analysis. The SGA-treated children had higher (p < .05) BMI z-score, waist-to-height ratio, fasting glucose, and LDL-cholesterol than SGA-naive children. Waist circumference, waist-to-height ratio, HDL cholesterol, fasting insulin, and HOMA-IR were significantly different by PA status. After adjusting for SGA-treatment duration, sex, age, and ethnicity, higher PA was associated with lower insulin resistance (HOMA-IR) in SGA-treated (mean, 95% CI; below vs. meets: 2.10 [1.84, 2.37] vs. 1.59 [1.37, 1.81], p = .046) but not in SGA-naive (1.70 [1.47, 1.94] vs 1.55 [1.35, 1.75], p = .707) children. Upon initial screening, SGA-treated children that reported meeting the minimal recommendations for daily PA displayed lower measures of adiposity and improved insulin resistance.
C1 [Cote, Anita T.; Devlin, Angela M.; Panagiotopoulos, Constadina] Univ British Columbia, Child & Family Res Inst, Dept Pediat, Vancouver, BC V5Z 1M9, Canada.
C3 Child & Family Research Institute; University of British Columbia
RP Panagiotopoulos, C (corresponding author), Univ British Columbia, Child & Family Res Inst, Dept Pediat, Vancouver, BC V5Z 1M9, Canada.
EM dpanagiotopoulos@cw.bc.ca
RI Panagiotopoulos, Constadina/AAO-6827-2020
OI Devlin, Angela/0000-0002-1390-6587; Panagiotopoulos,
   Constadina/0000-0002-1379-7472; Cote, Anita/0000-0003-3838-5893
FU British Columbia Mental Health & Substance Use Services; Child & Family
   Research Institute; Child & Family Research Institute Canucks for Kids;
   Michael Smith Foundation for Health Research /BC Schizophrenia Society
   Foundation; Canadian Diabetes Association
FX The authors wish to acknowledge Dr. Jana Davidson for her assistance in
   establishing subject recruitment protocols within the Department of
   Child & Adolescent Psychiatry at BC Children's Hospital as well as Dr.
   Duc Nguyen for database and statistical support. This work was supported
   by funding from the British Columbia Mental Health & Substance Use
   Services (Drs. Devlin and Panagiotopoulos) and a Capacity Building Award
   from the Child & Family Research Institute (Dr. Panagiotopoulos). Dr.
   Cote is supported by Child & Family Research Institute Canucks for Kids
   and Michael Smith Foundation for Health Research /BC Schizophrenia
   Society Foundation postdoctoral fellowships. Dr. Panagiotopoulos is
   supported by Clinician Scientist awards from the Canadian Diabetes
   Association and Child & Family Research Institute. Dr. Devlin is
   supported by an investigator award from the Child & Family Research
   Institute. The authors declare no conflict of interest.
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NR 42
TC 6
Z9 6
U1 0
U2 4
PU HUMAN KINETICS PUBL INC
PI CHAMPAIGN
PA 1607 N MARKET ST, PO BOX 5076, CHAMPAIGN, IL 61820-2200 USA
SN 0899-8493
EI 1543-2920
J9 PEDIATR EXERC SCI
JI Pediatr. Exerc. Sci.
PD NOV
PY 2014
VL 26
IS 4
BP 455
EP 462
DI 10.1123/pes.2014-0076
PG 8
WC Pediatrics; Physiology; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Pediatrics; Physiology; Sport Sciences
GA AT4QS
UT WOS:000344926300010
PM 25372380
DA 2025-06-11
ER

PT J
AU Bombardier, CH
   Dyer, JR
   Burns, P
   Crane, DA
   Takahashi, MM
   Barber, J
   Nash, MS
AF Bombardier, Charles H.
   Dyer, Joshua R.
   Burns, Patricia
   Crane, Deborah A.
   Takahashi, Melissa M.
   Barber, Jason
   Nash, Mark S.
TI A tele-health intervention to increase physical fitness in people with
   spinal cord injury and cardiometabolic disease or risk factors: a pilot
   randomized controlled trial
SO SPINAL CORD
LA English
DT Article
ID WHEELCHAIR USERS; SHOULDER PAIN; EXERCISE; INDIVIDUALS; DEPRESSION;
   ADULTS; PARTICIPATION; PERFORMANCE; MECHANISMS; DISABILITY
AB Study design Clinical trial. Objectives We used a single-blind parallel-group design to test the feasibility and preliminary efficacy of a telehealth-based physical activity counseling intervention to increase physical fitness in people with SCI. Setting Seattle, Washington, United States. Methods We recruited under-active, manual wheelchair-using adults at least 1-year post-SCI who had at least two cardiometabolic risk factors/diseases. Participants underwent baseline tests of peak cardiorespiratory fitness; lipids, glucose and insulin; muscle and fat mass; self-reported physical activity, depression, pain and other factors. Participants were assigned 1:1 to treatment vs. usual care (UC) control conditions via concealed computerized randomization. Treatment was delivered via telephone and adapted from the 16-session Diabetes Prevention Program. All baseline tests were repeated at 6 months. Prespecified feasibility goals were to recruit at least nine participants/quarter and retain 85% with complete fitness testing at 6 months. Prespecified efficacy goals were to demonstrate at least a medium treatment effect size (0.50) on fitness, self-reported physical activity, and other outcomes. Results Seven participants were randomized to treatment, 8 to UC over 15 months. Maximum recruitment was only 5.4 participants/quarter. Thirteen (87%) of participants were retained. The effects of treatment on fitness and most cardiometabolic risk factors did not meet expectations, whereas the effects on self-reported physical activity, depression, and pain did meet expectations. Conclusions The study did not meet key efficacy and feasibility objectives, yet there were some promising effects on self-report measures and lessons to be learned for designing future trials.
C1 [Bombardier, Charles H.; Crane, Deborah A.] Univ Washington, Dept Rehabil Med, Seattle, WA 98195 USA.
   [Dyer, Joshua R.] Peacehlth Med Grp, Vancouver, WA USA.
   [Burns, Patricia] Univ Miami, Miller Sch Med, Miami Project Cure Paralysis, Miami, FL 33136 USA.
   [Takahashi, Melissa M.] Univ Washington, Dept Ophthalmol, Seattle, WA 98195 USA.
   [Barber, Jason] Univ Washington, Dept Neurosurg, Seattle, WA 98195 USA.
   [Nash, Mark S.] Univ Miami, Miller Sch Med, Dept Neurol Surg, Miami, FL 33136 USA.
   [Nash, Mark S.] Univ Miami, Miller Sch Med, Dept Phys Med, Miami, FL 33136 USA.
   [Nash, Mark S.] Univ Miami, Miller Sch Med, Dept Rehabil & Phys Therapy, Miami, FL 33136 USA.
C3 University of Washington; University of Washington Seattle; University
   of Miami; University of Washington; University of Washington Seattle;
   University of Washington; University of Washington Seattle; University
   of Miami; University of Miami; University of Miami
RP Bombardier, CH (corresponding author), Univ Washington, Dept Rehabil Med, Seattle, WA 98195 USA.
EM chb@uw.edu
RI Bombardier, Charles/AAZ-3260-2021
OI Nash, Mark/0000-0003-4205-4130; Bombardier, Charles/0000-0003-4758-6283
FU Craig H. Neilsen Foundation, Psychosocial Research Grant [290122]
FX This research was funded by the Craig H. Neilsen Foundation,
   Psychosocial Research Grant Number 290122. The funder had no role in the
   conduct, interpreting or reporting the results of the study.
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NR 51
TC 21
Z9 23
U1 1
U2 13
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 1362-4393
EI 1476-5624
J9 SPINAL CORD
JI Spinal Cord
PD JAN
PY 2021
VL 59
IS 1
SI SI
BP 63
EP 73
DI 10.1038/s41393-020-0523-6
EA JUL 2020
PG 11
WC Clinical Neurology; Rehabilitation
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Rehabilitation
GA PU0GA
UT WOS:000551060900002
PM 32694748
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Choromanska, B
   Mysliwiec, P
   Luba, M
   Wojskowicz, P
   Mysliwiec, H
   Choromanska, K
   Dadan, J
   Zalewska, A
   Maciejczyk, M
AF Choromanska, Barbara
   Mysliwiec, Piotr
   Luba, Magdalena
   Wojskowicz, Piotr
   Mysliwiec, Hanna
   Choromanska, Katarzyna
   Dadan, Jacek
   Zalewska, Anna
   Maciejczyk, Mateusz
TI The Impact of Hypertension and Metabolic Syndrome on Nitrosative Stress
   and Glutathione Metabolism in Patients with Morbid Obesity
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Article
ID NITRIC-OXIDE SYNTHASE; NECROSIS-FACTOR-ALPHA; SUPEROXIDE-DISMUTASE;
   OXIDATIVE STRESS; INSULIN-RESISTANCE; S-NITROSOTHIOLS; PEROXYNITRITE;
   ACTIVATION; NITRATION; GLUCOSE
AB In this pathbreaking study, we evaluated nitrosative stress in morbidly obese patients with and without metabolic syndrome. 62 women with class 3 obesity (BMI>40 kg/m(2)) were divided into three subgroups: obese patients (OB), obese patients with hypertension (OB+HYP), and obese patients with metabolic syndrome (OB+MS). In comparison to the lean patients, OB had increased levels of serum myeloperoxidase (MPO), plasma nitric oxide (NO), S-nitrosothiols, and peroxynitrite (ONOO-), as well as nitrotyrosine, while oxidized glutathione (GSSG) rose only in OB+HYP group. Interestingly, ONOO(-)was significantly higher in OB+HYP and OB+MS as compared to OB group, while MPO only in OB+MS group. OB+MS had greater nitrotyrosine and S-nitrosothiol values than OB+HYP. Moreover, peroxynitrite could differentiate OB from OB+HYP and OB+MS (AUC 0.9292;p<0.0001; 87.5% sensitivity, 90% specificity) as well as between OB and OB+MS group (AUC 0.9125;p<0.0001; 81.25% sensitivity, 83.33%). In conclusion, we showed that MPO activity, NO formation, and nitrosative damage to proteins parallel the progression of metabolic disturbances of obesity. Evaluation of ONOO(-)concentrations may help predict the development of hypertension and metabolic syndrome in patients with morbid obesity; however, longer-term studies are required for larger numbers of patients.
C1 [Choromanska, Barbara; Mysliwiec, Piotr; Luba, Magdalena; Wojskowicz, Piotr; Dadan, Jacek] Med Univ Bialystok, Dept Gen & Endocrine Surg 1, 24a M Sklodowskiej Curie St, PL-15276 Bialystok, Poland.
   [Mysliwiec, Hanna] Med Univ Bialystok, Dept Dermatol & Venereol, 14 Zurawia St, PL-15540 Bialystok, Poland.
   [Choromanska, Katarzyna] Med Univ Gdansk, Dept Oral Surg, 7 Debinki St, PL-80211 Gdansk, Poland.
   [Zalewska, Anna] Med Univ Bialystok, Expt Dent Lab, 24a M Sklodowskiej Curie St, PL-15274 Bialystok, Poland.
   [Maciejczyk, Mateusz] Med Univ Bialystok, Dept Hyg Epidemiol & Ergon, 2c Mickiewicza St, PL-15233 Bialystok, Poland.
C3 Medical University of Bialystok; Medical University of Bialystok;
   Fahrenheit Universities; Medical University Gdansk; Medical University
   of Bialystok; Medical University of Bialystok
RP Maciejczyk, M (corresponding author), Med Univ Bialystok, Dept Hyg Epidemiol & Ergon, 2c Mickiewicza St, PL-15233 Bialystok, Poland.
EM barbara.choromanska@umb.edu.pl; piotr.a.mysliwiec@gmail.com;
   ananau@wp.pl; pwojsk@wp.pl; hanna.mysliwiec@gmail.com;
   kchoromanska@gumed.edu.pl; jacdad@poczta.onet.pl;
   azalewska426@gmail.com; mat.maciejczyk@gmail.com
RI Myśliwiec, Piotr/T-4220-2018; Zalewska, Anna/AAG-9484-2019; Myśliwiec,
   Hanna/S-6326-2018; Maciejczyk, Mateusz/R-6568-2018
OI Maciejczyk, Mateusz/0000-0001-5609-3187; Dadan,
   Jacek/0000-0002-0691-9785
FU Medical University of Bialystok, Poland [SUB/1/DN/20/002/1209,
   SUB/1/DN/20/002/3330, SUB/1/DN/19/001/1140]; Foundation for Polish
   Science (FNP)
FX This work was supported by grants from the Medical University of
   Bialystok, Poland (grant numbers: SUB/1/DN/20/002/1209;
   SUB/1/DN/20/002/3330; and SUB/1/DN/19/001/1140). Mateusz Maciejczyk, PhD
   was supported by the Foundation for Polish Science (FNP).
CR [Anonymous], 2006, 100+ years of advancing pharmacy worldwide
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NR 60
TC 20
Z9 21
U1 0
U2 5
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PD SEP 10
PY 2020
VL 2020
AR 1057570
DI 10.1155/2020/1057570
PG 10
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA NV4QO
UT WOS:000574308500003
PM 32963689
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Onyewuenyi, IC
   Muldoon, MF
   Christie, IC
   Erickson, KI
   Gianaros, PJ
AF Onyewuenyi, Ikechukwu C.
   Muldoon, Matthew F.
   Christie, Israel C.
   Erickson, Kirk I.
   Gianaros, Peter J.
TI Basal ganglia morphology links the metabolic syndrome and depressive
   symptoms
SO PHYSIOLOGY & BEHAVIOR
LA English
DT Article
DE Basal ganglia; Cardiovascular disease; Depression; Metabolic syndrome
ID BRAIN VOLUME ABNORMALITIES; CARDIOVASCULAR-DISEASE; SEROTONERGIC
   RESPONSIVITY; ENZYMATIC DETERMINATION; INSULIN-RESISTANCE;
   GLOBUS-PALLIDUS; MOOD DISORDERS; HUMAN STRIATUM; RISK-FACTORS; STROKE
   RISK
AB The metabolic syndrome (MetS) is a clustering of cardiovascular and cerebrovascular risk factors that are often comorbid with depressive symptoms. Individual components of the MetS also covary with the morphology of basal ganglia regions that are altered by depression. However, it remains unknown whether the covariation between the MetS and depressive symptomatology can be accounted for in part by morphological changes in the basal ganglia. Accordingly, we tested the hypothesis that increased depressive symptoms among individuals with the MetS might be statistically mediated by reduced gray matter volume in basal ganglia regions. The presence of the MetS was determined in 147 middle-aged adults using the criteria of the National Cholesterol Education Program, Adult Treatment Panel III. Basal ganglia volumes were determined on an a priori basis by automated segmentation of high-resolution magnetic resonance images. Depressive symptoms were assessed using the Patient Health Questionnaire. Even after controlling for demographic and other confounding factors, having the MetS and meeting more MetS criteria covaried with reduced globus pallidus volume. Meeting more MetS criteria and reduced pallidal volume were also related to depressive symptoms. Moreover, the MetS-depression association was statistically mediated by pallidal volume. In summary, reduced globus pallidus volume is a neural correlate of the MetS that may partly account for its association with depressive symptoms. (C) 2013 The Authors. Published by Elsevier Inc. All rights reserved.
C1 [Onyewuenyi, Ikechukwu C.; Erickson, Kirk I.; Gianaros, Peter J.] Univ Pittsburgh, Dept Psychol, Pittsburgh, PA 15260 USA.
   [Muldoon, Matthew F.] Univ Pittsburgh, Sch Med, Inst Heart & Vasc, Pittsburgh, PA 15260 USA.
   [Christie, Israel C.] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE); University
   of Pittsburgh; Pennsylvania Commonwealth System of Higher Education
   (PCSHE); University of Pittsburgh; University of Texas System; UTMD
   Anderson Cancer Center
RP Gianaros, PJ (corresponding author), Univ Pittsburgh, Dept Psychol, 3131 Sennott Sq,210 South Bouquet St, Pittsburgh, PA 15260 USA.
EM gianaros@pitt.edu
RI Erickson, Kirk/F-9997-2016
OI Erickson, Kirk/0000-0001-8736-981X
FU National Institutes of Health [HL089850, HL101421]
FX This work was funded by the National Institutes of Health Grants
   HL089850 and HL101421 to Peter J. Gianaros. The authors thank Sara
   Snyder for her assistance in data collection and Lei K. Sheu for her
   assistance in data reduction.
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NR 86
TC 13
Z9 16
U1 0
U2 12
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0031-9384
J9 PHYSIOL BEHAV
JI Physiol. Behav.
PD JAN 17
PY 2014
VL 123
BP 214
EP 222
DI 10.1016/j.physbeh.2013.09.014
PG 9
WC Psychology, Biological; Behavioral Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Behavioral Sciences
GA 293FJ
UT WOS:000329956500030
PM 24096008
OA hybrid, Green Accepted
DA 2025-06-11
ER

PT J
AU Tunçel, ÖK
   Akbas, S
   Bilgici, B
AF Tuncel, Ozgur Korhan
   Akbas, Seher
   Bilgici, Birsen
TI Increased Ghrelin Levels and Unchanged Adipocytokine Levels in Major
   Depressive Disorder
SO JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY
LA English
DT Article
DE ghrelin; insulin resistance; adipocytokine; depression; sertraline
ID METABOLIC SYNDROME; LEPTIN LEVELS; INSULIN-RESISTANCE; PLASMA LEPTIN;
   ASSOCIATION; ADIPONECTIN; OBESITY; SYMPTOMS; ADIPOKINES; CYTOKINES
AB Objective: One of the hypotheses of the pathophysiology of major depressive disorder (MDD) proposes that there is a relationship between adipocytokine and ghrelin levels and depression. Methods: Patients with major depression with a BMI 25kg/m(2) between the ages of 11 and 18 years (n=30) were compared with a healthy control group (n=30). Both groups were evaluated across a pretreatment period (MD-PT) and an improved period (MD-I). We measured serum leptin, adiponectin, resistin, and ghrelin levels and other parameters related to metabolic syndrome, such as glucose, insulin, insulin resistance (homeostasis model assessment [HOMA]), triglycerides (TG), and total cholesterol (TCHOL). Results: Leptin, adiponectin, and resistin levels did not differ across groups; however, ghrelin levels were increased in the MD-I group compared with the control and MD-PT groups (p<0.05). HOMA levels were also higher in the MD-PT group than in the control group (p<0.05). After treatment, there was no difference in this measurement. Conclusions: The relationship between adipocytokines and major depression may be dependent on ghrelin levels as a result of antidepressant treatment and subsequent obesity.
C1 [Tuncel, Ozgur Korhan; Bilgici, Birsen] Ondokuz Mays Univ, Dept Med Biochem, Fac Med, TR-55139 Kurupelit, Turkey.
   [Akbas, Seher] Ondokuz Mays Univ, Child & Adolescent Psychiat Dept, Fac Med, Samsun, Turkey.
C3 Ondokuz Mayis University; Ondokuz Mayis University
RP Tunçel, ÖK (corresponding author), Ondokuz Mays Univ, Dept Med Biochem, Fac Med, TR-55139 Kurupelit, Turkey.
EM ozgurkorhan@yahoo.com
OI Bilgici, Birsen/0000-0001-7783-5039; Akbas, Seher/0000-0002-1281-4103;
   TUNCEL, OZGUR KORHAN/0000-0002-2989-5894
FU Ondokuz Mayis University, Project Management Office
   [PYO.TIP.1901.14.008]
FX This study was supported by Ondokuz Mayis University, Project Management
   Office (Project No: PYO.TIP.1901.14.008).
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NR 62
TC 22
Z9 23
U1 0
U2 7
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1044-5463
EI 1557-8992
J9 J CHILD ADOL PSYCHOP
JI J. Child Adolesc. Psychopharmacol.
PD OCT
PY 2016
VL 26
IS 8
BP 733
EP 739
DI 10.1089/cap.2015.0149
PG 7
WC Pediatrics; Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics; Pharmacology & Pharmacy; Psychiatry
GA DZ8QN
UT WOS:000386136000010
PM 26862938
DA 2025-06-11
ER

EF﻿FN Clarivate Analytics Web of Science
VR 1.0
PT J
AU Ohashi, K
   Ohta, Y
   Ishikawa, H
   Kitagawa, A
AF Ohashi, Koji
   Ohta, Yoshiji
   Ishikawa, Hiroaki
   Kitagawa, Akira
TI Orally administered octacosanol improves some features of high
   fructose-induced metabolic syndrome in rats
SO JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION
LA English
DT Article
DE octacosanol; high fructose diet feeding (rats); metabolic syndrome;
   dyslipidemia; oxidative stress
ID OXIDATIVE STRESS; INSULIN-RESISTANCE; URIC-ACID; DIETARY FRUCTOSE;
   LIPID-METABOLISM; PROTECTIVE ROLE; PLASMA; CHOLESTEROL; SENSITIVITY;
   CONSUMPTION
AB We examined whether orally administered octacosanol, a long-chain aliphatic saturated alcohol, improves the features of high fructose-induced metabolic syndrome in rats. Five-week-old rats were fed a high fructose diet containing 60% fructose for 3 weeks. Then, the high fructose fed rats received a daily single oral administration of octacosanol (10 or 100 mg/kg body weight) with high fructose feeding for one week. Three- or four-week high fructose feeding increased insulin resistance, serum insulin, triglyceride, total cholesterol, free fatty acids, uric acid, and lipid peroxide concentrations, and hepatic triglyceride and cholesterol contents significantly and decreased serum high-density lipoprotein cholesterol and adiponectin concentrations significantly but did not affect blood pressure and hepatic lipid peroxide and reduced glutathione contents. Four-week high fructose feeding decreased hepatic ascorbic acid content significantly. Oral administration of octacosanol (10 or 50 mg/kg body weight) to high fructose-fed rats for the last 1-week fructose diet feeding attenuated these changes except serum insulin level and insulin resistance significantly and increased hepatic reduced glutathione content significantly. The higher dose of Oct decreased hepatic lipid peroxide content significantly. These results indicate that orally administered octacosanol improves dyslipidemia, hyperuricemia, hypoadiponectinemia, and oxidative stress associated with the features of high fructose-induced metabolic syndrome rats.
C1 [Ohashi, Koji; Ishikawa, Hiroaki] Fujita Hlth Univ, Sch Hlth Sci, Fac Clin Technol, Dept Biomed & Clin Sci,Sch Med, 1-98 Dengakugakubo,Kutsukake Cho, Toyoake, Aichi 4701192, Japan.
   [Ohta, Yoshiji] Fujita Hlth Univ, Sch Hlth Sci, Dept Chem, Sch Med, 1-98 Dengakugakubo,Kutsukake Cho, Toyoake, Aichi 4701192, Japan.
   [Kitagawa, Akira] Shigakkan Univ, Fac Hlth Wellness, Dept Nutr, 55 Nakoyama, Obu, Aichi 4748651, Japan.
C3 Fujita Health University; Fujita Health University
RP Ohta, Y (corresponding author), Fujita Hlth Univ, Sch Hlth Sci, Dept Chem, Sch Med, 1-98 Dengakugakubo,Kutsukake Cho, Toyoake, Aichi 4701192, Japan.
EM yohta@fujita-hu.ac.jp
FU Research Foundation of Fujita Health University
FX This work was supposed by a grant from the Research Foundation of Fujita
   Health University.
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NR 52
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Z9 3
U1 1
U2 12
PU JOURNAL CLINICAL BIOCHEMISTRY & NUTRITION
PI KYOTO
PA KYOTO PREFECTURAL UNIV MED, GRAD SCH MEDICAL SCIENCE, DEPT MOLECULAR
   GASTROENTEROLOGY & HEPATOLOGY, KYOTO, 602-8566, JAPAN
SN 0912-0009
EI 1880-5086
J9 J CLIN BIOCHEM NUTR
JI J. Clin. Biochem. Nutr.
PD JAN
PY 2021
VL 68
IS 1
BP 58
EP 66
DI 10.3164/jcbn.20-48
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA UE4TU
UT WOS:000687883500012
PM 33536713
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Vitaliano, PP
   Scanlan, JM
   Zhang, JP
   Savage, MV
   Hirsch, IB
   Siegler, IC
AF Vitaliano, PP
   Scanlan, JM
   Zhang, JP
   Savage, MV
   Hirsch, IB
   Siegler, IC
TI A path model of chronic stress, the metabolic syndrome, and coronary
   heart disease
SO PSYCHOSOMATIC MEDICINE
LA English
DT Review
DE stress; coronary disease; gender; metabolic syndrome; hormone
   replacement; path analysis
ID HORMONE REPLACEMENT THERAPY; MEDLEY HOSTILITY SCALE; RISK-FACTORS;
   ALZHEIMERS-DISEASE; GLYCEMIC CONTROL; SOCIAL SUPPORT; INSULIN; OBESITY;
   MENOPAUSE; ADJUSTMENT
AB Objective: We tested a theoretical stress model cross-sectionally and prospectively that examined whether relationships of chronic stress, psychophysiology, and coronary heart disease (CHD) varied in older adult men (N = 47), older adult women not using hormone replacement therapy (HRT) (N = 64), and older adult women using HRT (N = 41). Method: Structural equations examined relationships of CHD with 1) chronic stress (caring for a spouse with Alzheimer's disease and patient functioning), 2) vulnerability (anger and hostility), 3) social resources (supports), 4) psychological distress (burden, sleep problems, and low uplifts), 5) poor health habits (high-caloric, high-fat diet and limited exercise), and 6) the metabolic syndrome (MS) (blood pressure, obesity, insulin, glucose, and lipids). Results: Caregiver men had a greater prevalence of CHD (13/24) than did noncaregiver men (6/23) (p < .05) 27 to 30 months after study entry. This was influenced by pathways from caregiving to distress, distress to the MS, and the MS to CHD, In men, poor health habits predicted the MS 15 to 18 months later, and the MS predicted new CHD cases over 27 to 30 months. In women, no "caregiving-CHD" relationship occurred; however, 15 to 18 months after study entry women not using HRT showed "distress-MS" and "MS-CHD" relationships. In women using HRT, associations did not occur among distress, the MS, and CHD, but poor health habits and the MS were related. Conclusions: In older men, pathways occurred from chronic stress to distress to the metabolic syndrome, which in turn predicted CHD. Older women not using HRT showed fewer pathways than men; however, over time, distress, the MS, and CHD were related. No psychophysiological pathways occurred in older women using HRT.
C1 Univ Washington, Dept Psychiat & Behav Sci, Seattle, WA 98195 USA.
   Univ Washington, Dept Med, Seattle, WA 98195 USA.
   Duke Univ, Dept Psychiat & Behav Sci, Durham, NC USA.
C3 University of Washington; University of Washington Seattle; University
   of Washington; University of Washington Seattle; Duke University
RP Univ Washington, Dept Psychiat & Behav Sci, Box 356560, Seattle, WA 98195 USA.
EM pvital@u.washington.edu
RI Vitaliano, Peter/K-2014-2019; Zhang, Jian-Ping/L-9805-2016
OI Vitaliano, peter P./0000-0003-1598-0868; Zhang,
   Jian-Ping/0000-0001-6363-6362
FU NCI NIH HHS [P01CA72009] Funding Source: Medline; NCRR NIH HHS
   [M01-RR00037] Funding Source: Medline; NHLBI NIH HHS [R01 HL55356]
   Funding Source: Medline; NIA NIH HHS [R01 AG19605, R01 AG10760, 1R01
   AG12458] Funding Source: Medline; NIMH NIH HHS [R01 MH57663] Funding
   Source: Medline
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NR 101
TC 327
Z9 407
U1 0
U2 49
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0033-3174
EI 1534-7796
J9 PSYCHOSOM MED
JI Psychosom. Med.
PD MAY-JUN
PY 2002
VL 64
IS 3
BP 418
EP 435
DI 10.1097/00006842-200205000-00006
PG 18
WC Psychiatry; Psychology; Psychology, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry; Psychology
GA 555JV
UT WOS:000175791700006
PM 12021416
DA 2025-06-11
ER

PT J
AU Salonen, MK
   Kajantie, E
   Osmond, C
   Forsén, T
   Ylihärsilä, H
   Paile-Hyvärinen, M
   Barker, DJP
   Eriksson, JG
AF Salonen, M. K.
   Kajantie, E.
   Osmond, C.
   Forsen, T.
   Yliharsila, H.
   Paile-Hyvarinen, M.
   Barker, D. J. P.
   Eriksson, J. G.
TI Childhood growth and future risk of the metabolic syndrome in
   normal-weight men and women
SO DIABETES & METABOLISM
LA English
DT Article
DE Early growth; DOHaD; Metabolic syndrome; MONW
ID INCREASED OXIDATIVE STRESS; BODY-MASS INDEX; INSULIN-RESISTANCE;
   SERUM-LEVELS; PLASMA-LEVELS; BIRTH-WEIGHT; OBESE; LIFE; TRIGLYCERIDE;
   DEFINITION
AB Aim. - The aim of this study was to examine the effects of early growth on the risk of developing the metabolic syndrome in normal-weight individuals.
   Methods. - We examined 2003 subjects born in Helsinki, Finland, between 1934 and 1944, focusing on 588 individuals who were normal weight (body mass index [BMI] less than or equal to 25 kg/m(2)). These subjects had a median of seven measurements of height and weight from birth to 2 years, and eight measurements from 2 to 11 years of age. The metabolic syndrome was defined according to the 2005 criteria of the International Diabetes Federation.
   Results. - Individuals with the metabolic syndrome were heavier, had higher mean BMI and higher body fat percentages than those without the syndrome. No differences were seen in body size at birth and at 2 years but, by the age of 7 years, those men who later developed the metabolic syndrome were thinner (P = 0.01). Changes in BMI during infancy were predictive of the syndrome, with an OR of 0.57 (95% CI: 0.36-0.90) per one S.D. increase in BMI front birth to 2 years. In women, these associations paralleled those in men, but did not reach statistical significance.
   Conclusion. - Among normal-weight men, those who developed the metabolic syndrome in adulthood had smaller gains in BMI during infancy and were thinner at age 7 years. These results support findings that early growth may play an important role in the development of the metabolic syndrome. (C) 2009 Elsevier Masson SAS. All rights reserved.
C1 [Salonen, M. K.; Kajantie, E.; Forsen, T.; Yliharsila, H.; Paile-Hyvarinen, M.; Eriksson, J. G.] Natl Inst Hlth & Welf, Dept Chron Dis Prevent, Diabet Prevent Unit, Helsinki 00300, Finland.
   [Osmond, C.] Epidemiol Resource Ctr, Southampton, Hants, England.
   [Barker, D. J. P.] Univ Southampton, Dev Origins Hlth & Dis Div, Southampton, Hants, England.
   [Eriksson, J. G.] Univ Helsinki, Dept Gen Practice & Primary Hlth Care, FIN-00014 Helsinki, Finland.
   [Eriksson, J. G.] Vaasa Cent Hosp, Vaasa, Finland.
C3 Finland National Institute for Health & Welfare; University of
   Southampton; University of Helsinki; Vaasa Central Hospital
RP Salonen, MK (corresponding author), Natl Inst Hlth & Welf, Dept Chron Dis Prevent, Diabet Prevent Unit, Mannerheimintie 166, Helsinki 00300, Finland.
EM Minna.Salonen@ktl.fi
RI Gibbs, J. Raphael/A-3984-2010; Barker, David/A-5671-2013
OI Osmond, Clive/0000-0002-9054-4655; Eriksson, Johan/0000-0002-2516-2060
FU British Heart Foundation; Academy of Finland; Paivikki and Sakari
   Sohlberg Foundation; Finska Lakaresallskapet; Juho Vainio Foundation;
   Signe and Arne Gyllenberg Foundation; Finnish Foundation for
   Cardiovascular Research
FX The present study was supported by the British Heart Foundation, Academy
   of Finland, Paivikki and Sakari Sohlberg Foundation, Finska
   Lakaresallskapet, Juho Vainio Foundation, Signe and Arne Gyllenberg
   Foundation, and the Finnish Foundation for Cardiovascular Research.
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   Statistics Finland, CLASS SOC GROUPS 198
NR 40
TC 13
Z9 16
U1 0
U2 2
PU MASSON EDITEUR
PI MOULINEAUX CEDEX 9
PA 21 STREET CAMILLE DESMOULINS, ISSY, 92789 MOULINEAUX CEDEX 9, FRANCE
SN 1262-3636
EI 1878-1780
J9 DIABETES METAB
JI Diabetes Metab.
PD APR
PY 2009
VL 35
IS 2
BP 143
EP 150
DI 10.1016/j.diabet.2008.10.004
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 440BO
UT WOS:000265673300010
PM 19246227
DA 2025-06-11
ER

PT J
AU Tsai, HY
   Wu, LY
   Hwang, LS
AF Tsai, Hui-Yun
   Wu, Liang-Yi
   Hwang, Lucy Sun
TI Effect of a Proanthocyanidin-Rich Extract from Longan Flower on Markers
   of Metabolic Syndrome in Fructose-Fed Rats
SO JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
LA English
DT Article
DE Antioxidant; longan flowers; insulin resistance; blood pressure
ID INDUCED INSULIN-RESISTANCE; OXIDATIVE STRESS; ACTIVATION; ACID; CINNAMON
AB Recent evidence strongly suggests that oxidative stress due to redox imbalance is highly associated with metabolic syndrome. The objective of this study was to evaluate the effect of the supplementation of longan flower water extract (LFWE), which showed powerful antioxidative activity in vitro, on markers of metabolic syndrome in a fructose-fed rat model. Male Sprague-Dawley rats were randomly divided into four groups: group C, fed with standard Purina chow; group F, fed with high-fructose diet (HF) alone; group L, fed with HF plus LFWE 125 mg/kg bw per day by gavage; and group H, fed HF plus LFWE 250 mg/kg bw per day by gavage. The dietary manipulation lasted for 14 weeks. Results of our study showed that rats fed with HF resulted in oxidative stress and affected the antioxidant status including plasma thiobarbituric acid and liver antioxidant enzyme activity. Treatment with LFWE significantly augmented the antioxidant system. HF was able to cause insulin resistance and elevation of the blood pressure. The supplementation of LFWE ameliorated insulin resistance by enhancing the expression of insulin signaling pathway related proteins, including insulin receptor substrate-1 and glucose transporter 4. LFWE supplementation was also found to decrease systolic blood pressure. These findings indicate that longan flower water extract may improve the symptoms of metabolic syndrome in fructose-fed rats.
C1 [Tsai, Hui-Yun; Hwang, Lucy Sun] Natl Taiwan Univ, Grad Inst Food Sci & Technol, Taipei 106, Taiwan.
   [Wu, Liang-Yi] Chung Yuan Christian Univ, Dept Biosci Technol, Chungli 320, Taiwan.
C3 National Taiwan University; Chung Yuan Christian University
RP Hwang, LS (corresponding author), Natl Taiwan Univ, Grad Inst Food Sci & Technol, Number 1,Sect 4,Roosevelt Rd, Taipei 106, Taiwan.
EM lshwang@ntu.edu.tw
FU Nanhua longan farm
FX We thank the Nanhua longan farm for providing the longan flowers.
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NR 30
TC 37
Z9 39
U1 1
U2 16
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0021-8561
EI 1520-5118
J9 J AGR FOOD CHEM
JI J. Agric. Food Chem.
PD NOV 26
PY 2008
VL 56
IS 22
BP 11018
EP 11024
DI 10.1021/jf801966y
PG 7
WC Agriculture, Multidisciplinary; Chemistry, Applied; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture; Chemistry; Food Science & Technology
GA 374PR
UT WOS:000261056700087
PM 18973337
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Robberecht, H
   De Bruyne, T
   Hermans, N
AF Robberecht, Harry
   De Bruyne, Tess
   Hermans, Nina
TI Association between selenium status and metabolic syndrome and its
   biomarkers
SO TRACE ELEMENTS AND ELECTROLYTES
LA English
DT Article
DE metabolic syndrome; biomarkers; selenium blood concentration; daily
   intake
ID CIRCULATING SELENOPROTEIN P; TRACE-ELEMENTS; OXIDATIVE STRESS; SERUM
   SELENIUM; ANTIOXIDANT CONCENTRATIONS; TOENAIL SELENIUM; NATIONAL-HEALTH;
   HEAVY-METALS; FAT OVERLOAD; PLASMA
AB Background: Since selenium (Se) constitutes a functional part of antioxidant enzymes, this element is considered to counteract oxidative stress in metabolic syndrome (MetS). Materials and methods: Literature was screened for publications from January 2010 up to November 2019. Keywords in various combinations were used. Results: Conflicting data were found for a possible correlation of MetS and various indicators of Se status. For Se levels in human blood, most of the publications tend to indicate a positive association with biomarkers of MetS, especially parameters in the lipid profile. Conclusion: The complex character of MetS and the various diagnostic criteria and biomarkers used are factors contributing to the conflicting results. Other confounding factors are the sampled population with variation in baseline Se level, age, gender, size of the groups, and lack of control on medication and other antioxidants taken.
C1 [Robberecht, Harry; De Bruyne, Tess; Hermans, Nina] Univ Antwerp, Res Grp Nat, Dept Pharmaceut Sci, Fac Pharmaceut Biomed & Vet Sci, Antwerp, Belgium.
C3 University of Antwerp
RP Robberecht, H (corresponding author), Univ Antwerp, Res Grp Nat, Dept Pharmaceut Sci, Fac Pharmaceut Biomed & Vet Sci, Antwerp, Belgium.
EM labrom@uantwerpen.be
RI Hermans, Nina/A-5244-2017
OI Hermans, Nina/0000-0003-3946-7313
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NR 84
TC 0
Z9 0
U1 1
U2 7
PU DUSTRI-VERLAG DR KARL FEISTLE
PI DEISENHOFEN-MUENCHEN
PA BAHNHOFSTRASSE 9 POSTFACH 49, D-82032 DEISENHOFEN-MUENCHEN, GERMANY
SN 0946-2104
J9 TRACE ELEM ELECTROLY
JI Trace Elem. Electrolytes
PY 2021
VL 38
IS 1
BP 13
EP 20
DI 10.5414/TEX01646
PG 8
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA QA2AP
UT WOS:000613251000003
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Sostaric, A
   Jenko, B
   Kozjek, NR
   Ovijac, D
   Suput, D
   Milisav, I
   Dolzan, V
AF Sostaric, Anja
   Jenko, Barbara
   Kozjek, Nada Rotovnik
   Ovijac, Darja
   Suput, Dusan
   Milisav, Irina
   Dolzan, Vita
TI Detection of metabolic syndrome burden in healthy young adults may
   enable timely introduction of disease prevention
SO ARCHIVES OF MEDICAL SCIENCE
LA English
DT Article
DE metabolic syndrome; young adults; anthropometry; nutrition; exercise
ID 3RD NATIONAL-HEALTH; C-REACTIVE PROTEIN; OXIDATIVE STRESS; LIFE-STYLE;
   CARDIOVASCULAR-DISEASE; MYOCARDIAL-INFARCTION; RHEUMATOID-ARTHRITIS;
   SUPEROXIDE-DISMUTASE; CONFERS PROTECTION; ABDOMINAL OBESITY
AB Introduction: Metabolic syndrome and associated diseases are a global health problem. Detection of early metabolic modifications that may lead to metabolic syndrome would enable timely introduction of preventive lifestyle modifications.
   Material and methods: In total 103 young, healthy adults were assessed for indicators of metabolic alterations. Anthropometric, lifestyle, genetic and biochemical parameters were assessed. Individuals who fulfilled at least one criterion for diagnosis of metabolic syndrome were assigned to the group with the higher metabolic syndrome burden (B-MeS).
   Results: The 34 young healthy individuals who were assigned to the B-MeS group had lower fat-free mass, higher body mass index, waist-to-hip ratio, fat mass, and blood pressure, more visceral fat, they were less physically active, had higher C-reactive protein values and higher catalase activity. Their phenotype was more similar to that of patients diagnosed with metabolic syndrome than the rest of the population.
   Conclusions: Simple anthropometric measurements, lifestyle assessment and basic biochemical measurements can be used to identify young healthy individuals with increased risk for metabolic syndrome. These assessments can be performed at periodic check-ups of the healthy population so that timely diagnosis of B-MeS can be made. As lifestyle factors have a big influence on development or improvement of the MeS, the timely diagnosis for B-MeS would enable an early opportunity for intervention for lifestyle modification in the still healthy population, saving costs and reducing disability adjusted life years.
C1 [Sostaric, Anja; Ovijac, Darja; Milisav, Irina] Univ Ljubljana, Fac Hlth Sci, Ljubljana, Slovenia.
   [Jenko, Barbara; Kozjek, Nada Rotovnik; Dolzan, Vita] Univ Ljubljana, Inst Biochem, Fac Med, Ljubljana, Slovenia.
   [Kozjek, Nada Rotovnik] Inst Oncol, Ljubljana, Slovenia.
   [Suput, Dusan; Milisav, Irina] Univ Ljubljana, Inst Pathophysiol, Fac Med, Ljubljana, Slovenia.
C3 University of Ljubljana; University of Ljubljana; Institute of Oncology
   - Slovenia; University of Ljubljana
RP Milisav, I (corresponding author), Univ Ljubljana, Inst Pathophysiol, Fac Med, Ljubljana, Slovenia.
EM irina.milisav@mf.uni-lj.si
RI Suput, Dusan/AAR-7379-2021
OI Suput, Dusan/0000-0003-4031-7267
FU Slovenian Research Agency [P1-0170, P3-0019, H2020MSCA-ITN: 721236]
FX The authors acknowledge the financial support from the Slovenian
   Research Agency (research core funding No. P1-0170 and P3-0019). This
   study was also partially supported by the H2020MSCA-ITN: 721236
   TREATMENT project.
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NR 62
TC 13
Z9 14
U1 1
U2 7
PU TERMEDIA PUBLISHING HOUSE LTD
PI POZNAN
PA KLEEBERGA ST 2, POZNAN, 61-615, POLAND
SN 1734-1922
EI 1896-9151
J9 ARCH MED SCI
JI Arch. Med. Sci.
PD SEP
PY 2019
VL 15
IS 5
BP 1184
EP 1194
DI 10.5114/aoms.2019.87462
PG 11
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA IW2CU
UT WOS:000484782500009
PM 31572463
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Weinstock, LM
   Gaudiano, BA
   Epstein-Lubow, G
   Tezanos, K
   Celis-deHoyos, CE
   Miller, IW
AF Weinstock, Lauren M.
   Gaudiano, Brandon A.
   Epstein-Lubow, Gary
   Tezanos, Katherine
   Celis-deHoyos, Cintly E.
   Miller, Ivan W.
TI Medication burden in bipolar disorder: A chart review of patients at
   psychiatric hospital admission
SO PSYCHIATRY RESEARCH
LA English
DT Article
DE Polypharmacy; Bipolar depression; Mood stabilizers; Antidepressants;
   Benzodiazepines; Demography; Psychopharmacology
ID PSYCHOTROPIC-DRUG PRESCRIPTION; ANXIETY TREATMENTS CANMAT; WEEKLY
   SYMPTOMATIC STATUS; I DISORDER; TREATMENT ADHERENCE; METABOLIC SYNDROME;
   CANADIAN NETWORK; NATURAL-HISTORY; POLYPHARMACY; GUIDELINES
AB Individuals with bipolar disorder (BD) often receive complex polypharmacy regimens as part of treatment, yet few studies have sought to evaluate patient characteristics associated with this high medication burden. This retrospective chart review study examined rates of complex polypharmacy (i.e., >= 4 psychotropic medications), patterns of psychotropic medication use, and their demographic and clinical correlates in a naturalistic sample of adults with bipolar I disorder (BDI; N=230) presenting for psychiatric hospital admission. Using a computer algorithm, a hospital administrator extracted relevant demographic, clinical, and community treatment information for analysis. Patients reported taking an average of 3.31 (S.D.=1.46) psychotropic medications, and 5.94 (S.D.=3.78) total medications at intake. Overall, 82 (36%) met criteria for complex polypharmacy. Those receiving complex polypharmacy were significantly more likely to be female, to be depressed, to have a comorbid anxiety disorder, and to have a history of suicide attempt. Women were significantly more likely than men to be prescribed antidepressants, benzodiazepines, and stimulants, even after controlling for mood episode polarity. Study data highlight the high medication burden experienced by patients with BD, especially those who are acutely symptomatic. Data also highlight the particularly high medication burden experienced by women with BD; a burden not fully accounted for by depression. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
C1 [Weinstock, Lauren M.] Brown Univ, Alpert Med Sch, Providence, RI 02906 USA.
   [Weinstock, Lauren M.] Butler Hosp, Providence, RI 02906 USA.
C3 Brown University; Butler Hospital Rhode Island
RP Weinstock, LM (corresponding author), Brown Univ, Alpert Med Sch, 345 Blackstone Blvd, Providence, RI 02906 USA.
EM Lauren_Weinstock@Brown.edu
RI Gaudiano, Brandon/MZQ-6750-2025
OI Weinstock, Lauren/0000-0001-9970-235X; Gaudiano,
   Brandon/0000-0002-1843-4910
FU National Institute of Mental Health [K23MH079907]
FX Preparation of this manuscript was supported by Grant K23MH079907 from
   the National Institute of Mental Health, awarded to Dr. Weinstock.
CR [Anonymous], 2002, PRACT GUID TREATM PA
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NR 44
TC 40
Z9 43
U1 0
U2 7
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0165-1781
J9 PSYCHIAT RES
JI Psychiatry Res.
PD APR 30
PY 2014
VL 216
IS 1
BP 24
EP 30
DI 10.1016/j.psychres.2014.01.038
PG 7
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA AE6XL
UT WOS:000334141200005
PM 24534121
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Yamada, S
   Guo, X
AF Yamada, Sohsuke
   Guo, Xin
TI Peroxiredoxin 4 (PRDX4): Its critical in vivo roles in animal
   models of metabolic syndrome ranging from atherosclerosis to
   nonalcoholic fatty liver disease
SO PATHOLOGY INTERNATIONAL
LA English
DT Review
DE animal model; chronic inflammatory disease; human PRDX4 transgenic mice
   (Tg); metabolic syndrome; peroxiredoxin (PRDX) 4
ID REGULATING KINASE 1; PANCREATIC BETA-CELLS; HIGH-FRUCTOSE DIET;
   HISTAMINE-RECEPTORS; OXIDATIVE STRESS; MACROPHAGE APOPTOSIS;
   DIABETIC-RATS; KAPPA-B; PROTECTS; STEATOHEPATITIS
AB The peroxiredoxin (PRDX) family, a new family of proteins with a pivotal antioxidative function, is ubiquitously synthesized and abundantly identified in various organisms. In contrast to the intracellular localization of other family members (PRDX1/2/3/5/6), PRDX4 is the only known secretory form and protects against oxidative damage by scavenging reactive oxygen species in both the intracellular (especially the endoplasmic reticulum) compartments and the extracellular space. We generated unique human PRDX4 (hPRDX4) transgenic (Tg) mice on a C57BL/6J background and investigated the critical and diverse protective roles of PRDX4 against diabetes mellitus, atherosclerosis, insulin resistance, and nonalcoholic fatty liver disease (NAFLD) as well as evaluated its role in the intestinal function in various animal models. Our published data have shown that PRDX4 helps prevent the progression of metabolic syndrome by reducing local and systemic oxidative stress and synergistically suppressing steatosis, inflammatory reactions, and/or apoptotic activity. These observations suggest that Tg mice may be a useful animal model for studying the relevance of oxidative stress on inflammation and the dysregulation of lipid/bile acid/glucose metabolism upon the progression of human metabolic syndrome, and that specific accelerators of PRDX4 may be useful as therapeutic agents for ameliorating various chronic inflammatory diseases.
C1 [Yamada, Sohsuke; Guo, Xin] Kanazawa Med Univ, Dept Pathol & Lab Med, 1-1 Uchinada, Kanazawa, Ishikawa 9200293, Japan.
   [Guo, Xin] Hebei Med Univ, Lab Pathol, Hebei Canc Inst, Hosp 4, Shijiazhuang, Hebei, Peoples R China.
C3 Kanazawa Medical University; Hebei Medical University
RP Yamada, S (corresponding author), Kanazawa Med Univ, Dept Pathol & Lab Med, 1-1 Uchinada, Kanazawa, Ishikawa 9200293, Japan.
EM sohsuke@kanazawa-med.ac.jp
RI Guo, Xin/ABH-1202-2021
FU MSD Life Science Foundation; Public Interest Incorporated Foundation,
   Japan; Ministry of Education, Culture, Sports, Science and Technology,
   Tokyo, Japan [24790394, 16K08750]; National Natural Science Foundation
   of China [81402490]; Natural Science Foundation of Hebei Province
   [H2016206170]; high-level talent support project of Hebei Province
   [CG2015003011]; Grants-in-Aid for Scientific Research [16K08750] Funding
   Source: KAKEN
FX This work was supported in part by a grant from the MSD Life Science
   Foundation, Public Interest Incorporated Foundation, Japan (to S.Y.); by
   Grants-in-Aid for Scientific Research (24790394 and 16K08750) from the
   Ministry of Education, Culture, Sports, Science and Technology, Tokyo,
   Japan (to S.Y.); and by grants from National Natural Science Foundation
   of China (Number 81402490), Natural Science Foundation of Hebei Province
   (Number H2016206170), and high-level talent support project of Hebei
   Province (Number CG2015003011) (to X.G.). We would like to thank Hiroko
   Isagai, Hana Nishimura, and Naoko Tasaki for their expert technical
   assistance.
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NR 61
TC 40
Z9 43
U1 0
U2 21
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1320-5463
EI 1440-1827
J9 PATHOL INT
JI Pathol. Int.
PD FEB
PY 2018
VL 68
IS 2
BP 91
EP 101
DI 10.1111/pin.12634
PG 11
WC Pathology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pathology
GA FV9QR
UT WOS:000424923700002
PM 29341349
DA 2025-06-11
ER

PT J
AU Oku, H
   Ogawa, Y
   Iwaoka, E
   Yamaguchi, Y
   Kagota, S
   Kazumasa, S
   Kunitomo, M
   Ishiguro, K
AF Oku, Hisae
   Ogawa, Yuko
   Iwaoka, Emiko
   Yamaguchi, Yu
   Kagota, Satomi
   Kazumasa, Shinozuka
   Kunitomo, Masaru
   Ishiguro, Kyoko
TI Preventive effects of the extract of kinka-cha, a folk tea, on a rat
   model of metabolic syndrome
SO JOURNAL OF NATURAL MEDICINES
LA English
DT Article
DE Camellia nitidissima; SHR/NDmcr-cp/cp (SHR/cp) rats; Antioxidants
ID CORPULENT RAT; CP RATS; MYELOPEROXIDASE; OXIDANTS
AB Kinka-cha (dried leaf of Camellia nitidissima) is used as a folk tea for detoxication, diuresis and antihypertension. In the present study, we evaluated the extract of kinka-cha on metabolic, vascular and oxidative stress parameters in a model of metabolic syndrome, SHR/NDmcr-cp/cp (SHR/cp) rats that manifest hypertension, obesity, glucose intolerance and hyperlipidemia. Treatment with the extract of kinka-cha alleviated the increase in blood pressure, decrease in tail blood flow and elevated serum oxidative stress marker levels including lipid peroxides, 8-hydroxy-2'-deoxyguanosine, 3-nitrotyrosine and 3-chlorotyrosine. However, kinka-cha did not affect weight gain, hyperglycemia and hyperlipidemia, nor the relaxation responses of the aorta mesenteric artery, thoracic aortas and tail vein, and blood clotting and platelet aggregation. These results suggest that kinka-cha can help reduce the risk of developing metabolic syndrome, possibly due to the presence of antioxidants.
C1 [Oku, Hisae; Ogawa, Yuko; Iwaoka, Emiko; Yamaguchi, Yu; Kagota, Satomi; Kazumasa, Shinozuka; Kunitomo, Masaru; Ishiguro, Kyoko] Mukogawa Womens Univ, Sch Pharm & Pharmaceut Sci, Nishinomiya, Hyogo 6638179, Japan.
C3 Mukogawa Women's University
RP Ishiguro, K (corresponding author), Mukogawa Womens Univ, Sch Pharm & Pharmaceut Sci, 11-68 Koshien Kuban Cho, Nishinomiya, Hyogo 6638179, Japan.
EM ishiguro@mukogawa-u.ac.jp
FU Mukogawa Women's University for studying lifestyle-related disease,
   Japan
FX This research was supported by the Open Research Center Project of
   Mukogawa Women's University for studying lifestyle-related disease,
   Japan.
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NR 18
TC 13
Z9 14
U1 0
U2 15
PU SPRINGER JAPAN KK
PI TOKYO
PA SHIROYAMA TRUST TOWER 5F, 4-3-1 TORANOMON, MINATO-KU, TOKYO, 105-6005,
   JAPAN
SN 1340-3443
EI 1861-0293
J9 J NAT MED-TOKYO
JI J. Nat. Med.
PD JUL
PY 2011
VL 65
IS 3-4
BP 610
EP 616
DI 10.1007/s11418-011-0523-0
PG 7
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 778ZC
UT WOS:000291746900028
PM 21479861
DA 2025-06-11
ER

PT J
AU Callaghan, B
   Feldman, E
AF Callaghan, Brian
   Feldman, Eva
TI The Metabolic Syndrome and Neuropathy: Therapeutic Challenges and
   Opportunities
SO ANNALS OF NEUROLOGY
LA English
DT Article
ID IMPAIRED GLUCOSE-TOLERANCE; LIFE-STYLE INTERVENTION;
   DIABETIC-NEUROPATHY; PERIPHERAL NEUROPATHY; CHRONIC COMPLICATIONS;
   INCREASED PREVALENCE; INSULIN-RESISTANCE; NATIONAL-HEALTH; MTOR
   INHIBITORS; PAINFUL
AB The metabolic syndrome and neuropathy are common conditions, especially in the elderly, that are associated with significant morbidity. Furthermore, the metabolic syndrome is reaching epidemic proportions across the world. Current evidence supports the association of the metabolic syndrome and its individual components with neuropathy. Several clinical trials have demonstrated that treating hyperglycemia, a component of the metabolic syndrome, has a significant effect on reducing the incidence of neuropathy in those with type 1 diabetes. However, glucose control has only a marginal effect on preventing neuropathy in those with type 2 diabetes, suggesting that other factors may be driving nerve injury in these patients. Emerging evidence supports the metabolic syndrome as including risk factors for neuropathy. Interventions exist for treatment of all of the metabolic syndrome components, but only glucose control has strong evidence to support its use and is widely employed. Our understanding of the biology of metabolic nerve injury has rapidly expanded over the past several years. Mechanisms of injury include fatty deposition in nerves, extracellular protein glycation, mitochondrial dysfunction, and oxidative stress. Additionally, the activation of counter-regulatory signaling pathways leads to chronic metabolic inflammation. Medications that target these signaling pathways are being used for a variety of diseases and are intriguing therapeutic agents for future neuropathy clinical trials. As we move forward, we need to expand our understanding of the association between the metabolic syndrome and neuropathy by addressing limitations of previous studies. Just as importantly, we must continue to investigate the pathophysiology of metabolically induced nerve injury. Ann Neurol 2013;74:397-403
C1 [Callaghan, Brian; Feldman, Eva] Univ Michigan, Dept Neurol, Ann Arbor, MI USA.
C3 University of Michigan System; University of Michigan
RP Feldman, E (corresponding author), 109 Zina Pitcher Pl,5017 AAT BSRB, Ann Arbor, MI 48109 USA.
EM efeldman@umich.edu
OI Feldman, Eva/0000-0002-9162-2694
FU A. Alfred Taubman Medical Research Institute; Katherine Rayner Program;
   Program for Neurology Research and Discovery; American Diabetes
   Association; NIH [K23 NS079417, RO1 NS077982, 1DP3DK094292]; NIH
   National Institute on Aging [2P01 AG020591-06A1]; NIH National Institute
   of Diabetes and Digestive and Kidney Diseases [1 R24 082841]; National
   Institute of Diabetes and Digestive and Kidney Diseases [P30DK020572]
   Funding Source: NIH RePORTER
FX B.C. and E. F. are supported by the A. Alfred Taubman Medical Research
   Institute, the Katherine Rayner Program, and the Program for Neurology
   Research and Discovery. B. C. is also supported by an American Diabetes
   Association Junior Faculty Award and an NIH K23 (K23 NS079417) award. E.
   F. is also supported by NIH RO1 NS077982, NIH 1DP3DK094292, NIH National
   Institute on Aging 2P01 AG020591-06A1, and NIH National Institute of
   Diabetes and Digestive and Kidney Diseases 1 R24 082841.
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NR 65
TC 89
Z9 100
U1 0
U2 23
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0364-5134
EI 1531-8249
J9 ANN NEUROL
JI Ann. Neurol.
PD SEP
PY 2013
VL 74
IS 3
BP 397
EP 403
DI 10.1002/ana.23986
PG 7
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 232BJ
UT WOS:000325463100016
PM 23929529
OA Green Accepted, Green Published
DA 2025-06-11
ER

PT J
AU Kash, N
   Leavitt, M
   Leavitt, A
   Hawkins, SD
   Roopani, RB
AF Kash, Natalie
   Leavitt, Matt
   Leavitt, Adam
   Hawkins, Spencer D.
   Roopani, Rahil B.
TI Clinical Patterns of Hair Loss in Men Is Dihydrotestosterone the Only
   Culprit?
SO DERMATOLOGIC CLINICS
LA English
DT Article
DE Alopecia; Androgenetic alopecia; Pathway; Oxidative stress;
   Inflammation; Prostaglandin; Comorbidities; Risk factor
ID DERMAL PAPILLA CELLS; POLYCYSTIC OVARIAN SYNDROME; ANDROGEN-INDUCIBLE
   TGF-BETA-1; INDUCED DICKKOPF-1 EXPRESSION; CARDIOVASCULAR RISK-FACTORS;
   ENDOTHELIAL GROWTH-FACTOR; OXIDATIVE STRESS; EARLY-ONSET; METABOLIC
   SYNDROME; PREMATURE SENESCENCE
C1 [Kash, Natalie; Leavitt, Matt] Kansas City Univ, Dept Dermatol, Grad Med Educ Consortium, Adv Dermatol & Cosmet Surg Orlando Dermatol Progr, 260 Lookout Pl,Suite 103, Maitland, FL 32751 USA.
   [Leavitt, Matt] Adv Dermatol & Cosmet Surg, Maitland, FL USA.
   [Leavitt, Matt] Univ Cent Florida, Coll Med, Orlando, FL 32816 USA.
   [Leavitt, Matt] Bosley Med Grp, Maitland, FL USA.
   [Leavitt, Adam; Hawkins, Spencer D.] Univ Michigan, Dept Dermatol, Ann Arbor, MI 48109 USA.
   [Roopani, Rahil B.] Leavitt Med Associates, Hair Restorat Surg Program, 260 Lookout Pl,Suite 103, Maitland, FL 32751 USA.
   [Leavitt, Adam; Hawkins, Spencer D.] 1500 East Med Ctr Dr, Ann Arbor, MI 48103 USA.
C3 State University System of Florida; University of Central Florida;
   University of Michigan System; University of Michigan
RP Leavitt, M (corresponding author), 260 Lookout Pl,Suite 103, Maitland, FL 32751 USA.
EM DrMattL@leavittmgt.com
RI Kash, Natalie/IQU-7956-2023
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NR 119
TC 6
Z9 6
U1 5
U2 39
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0733-8635
EI 1558-0520
J9 DERMATOL CLIN
JI Dermatol. Clin.
PD JUL
PY 2021
VL 39
IS 3
BP 361
EP 370
DI 10.1016/j.det.2021.03.001
EA MAY 2021
PG 10
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA SM3FP
UT WOS:000657495800002
PM 34053589
DA 2025-06-11
ER

PT J
AU Dhingra, R
   He, F
   Al-Shaar, L
   Saunders, EFH
   Chinchilli, VM
   Yanosky, JD
   Liao, D
AF Dhingra, Radha
   He, Fan
   Al-Shaar, Laila
   Saunders, Erika F. H.
   Chinchilli, Vernon M.
   Yanosky, Jeff D.
   Liao, Duanping
TI Cardiovascular disease burden is associated with worsened depression
   symptoms in the US general population
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE NHANES; PHQ-9; Depression; Cardiovascular disease; Population-based
   study
ID METABOLIC SYNDROME; RISK-FACTORS; MAJOR DEPRESSION; HEART-DISEASE;
   UNITED-STATES; ANXIETY; IMPACT; RECOMMENDATIONS; DYSLIPIDEMIA;
   METAANALYSIS
AB Background: Cardiovascular disease (CVD) and depression are the leading causes of disability in the U.S. Using five cycles (2009-2018) of the U.S. National Health and Nutrition Examination Survey, we examined the crosssectional association between CVD risk factor burden and depression severity in nonpregnant adults with no history of CVD events.Methods: With at least 3000 participants per cycle, the overall N was 18,175. CVD risk factors were ascertained through self-report, lab tests, or medications. The sum of hypertension, diabetes, dyslipidemia, and current smoking represented a CVD risk score variable (range: 0-4). Depression severity was assessed using scores on the 9-item patient health questionnaire: 0-9 (none-mild) and 10-27 (moderate-to-severe). Logistic regression models were performed to investigate the association between CVD risk score categories and moderate-to-severe depression. Cycle-specific odds ratios (OR) were meta-analyzed to obtain a pooled OR (95 % CI) (Q-statistic p > 0.05).Results: Compared to participants with no CVD risk factors, participants with risk scores of 1, 2, 3, and 4, had 1.28 (0.92-1.77), 2.18 (1.62-2.94), 2.53 (1.86-3.49), 2.97 (1.67-5.31) times higher odds of moderate-to-severe depression, respectively, after adjusting for socio-demographics and antidepressant use (linear trend p < 0.0001). This relationship persisted after additionally adjusting for lifestyle variables. Limitations: NHANES data is cross-sectional and self-reported, thus preventing causal assessments and leading to potential recall bias.Conclusions: Among U.S. adults, CVD risk factor burden was associated with worsened depression symptoms. Integrated mental and physical healthcare services could improve risk stratification among persons with CVD and depression, possibly reducing long-term disability and healthcare costs.
C1 [Dhingra, Radha; He, Fan; Al-Shaar, Laila; Chinchilli, Vernon M.; Yanosky, Jeff D.; Liao, Duanping] Penn State Coll Med, Dept Publ Hlth Sci, Hershey, PA USA.
   [Saunders, Erika F. H.] Penn State Coll Med, Dept Psychiat & Behav Hlth, Hershey, PA USA.
   [Saunders, Erika F. H.] Penn State Milton S Hershey Med Ctr, Hershey, PA USA.
   [Liao, Duanping] Penn State Coll Med, Dept Publ Hlth Sci, 90 Hope Dr,Suite 2200,A210, Hershey, PA 17033 USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE);
   Pennsylvania State University; Penn State Health; Pennsylvania
   Commonwealth System of Higher Education (PCSHE); Pennsylvania State
   University; Penn State Health; Pennsylvania Commonwealth System of
   Higher Education (PCSHE); Pennsylvania State University; Penn State
   Health; Pennsylvania Commonwealth System of Higher Education (PCSHE);
   Pennsylvania State University; Penn State Health
RP Liao, D (corresponding author), Penn State Coll Med, Dept Publ Hlth Sci, 90 Hope Dr,Suite 2200,A210, Hershey, PA 17033 USA.
EM dliao@psu.edu
RI Saunders, Erika/J-4964-2013
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NR 63
TC 13
Z9 14
U1 0
U2 5
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD FEB 15
PY 2023
VL 323
BP 866
EP 874
DI 10.1016/j.jad.2022.12.038
EA DEC 2022
PG 9
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA A3BO5
UT WOS:000953920300001
PM 36566933
DA 2025-06-11
ER

PT J
AU Lipsitz, O
   McIntyre, RS
   Rodrigues, NB
   Lee, Y
   Gill, H
   Subramaniapillai, M
   Kratiuk, K
   Nasri, F
   Mansur, RB
   Rosenblat, JD
AF Lipsitz, Orly
   McIntyre, Roger S.
   Rodrigues, Nelson B.
   Lee, Yena
   Gill, Hartej
   Subramaniapillai, Mehala
   Kratiuk, Kevin
   Nasri, Flora
   Mansur, Rodrigo B.
   Rosenblat, Joshua D.
TI Does body mass index predict response to intravenous ketamine treatment
   in adults with major depressive and bipolar disorder? Results from the
   Canadian Rapid Treatment Center of Excellence
SO CNS SPECTRUMS
LA English
DT Article
DE Adiposity; esketamine; glutamate; obesity; overweight
ID ANTIDEPRESSANT RESPONSE; METABOLIC SYNDROME; SUICIDAL IDEATION; OBESITY;
   EFFICACY; SYMPTOMATOLOGY; ASSOCIATION; OVERWEIGHT; ADIPOKINES; MODERATOR
AB Background Higher body mass index (BMI) has been found to predict greater antidepressant response to intravenous (IV) ketamine treatment. We evaluated the association between BMI and response to repeat-dose IV ketamine in patients with treatment-resistant depression (TRD). Methods Adults (N = 230) with TRD received four infusions of IV ketamine at a community-based clinic. Changes in symptoms of depression (ie, Quick Inventory for Depressive Symptomatology-Self-Report 16; QIDS-SR16), suicidal ideation (SI; ie, QIDS-SR16 SI item), anxiety (ie, Generalized Anxiety Disorder-7 Scale), anhedonic severity (ie, Snaith-Hamilton Pleasure Scale), and functioning (ie, Sheehan Disability Scale) following infusions were evaluated. Participants were stratified by BMI as normal (18.0-24.9 kg/m(2); n = 72), overweight (25-29.9 kg/m(2); n = 76), obese I (30-34.9 kg/m(2); n = 47), or obese II (>= 35.0 kg/m(2); n = 35). Results Similar antidepressant effects with repeat-dose ketamine were reported between BMI groups (P = .261). In addition, categorical partial response (P = .149), response (P = .526), and remission (P = .232) rates were similar between the four BMI groups. Conclusions The findings are limited by the observational, open-label design of this retrospective analysis. Pretreatment BMI did not predict response to IV ketamine, which was effective regardless of BMI.
C1 [Lipsitz, Orly; McIntyre, Roger S.; Rodrigues, Nelson B.; Lee, Yena; Gill, Hartej; Subramaniapillai, Mehala; Nasri, Flora; Mansur, Rodrigo B.; Rosenblat, Joshua D.] Univ Hlth Network, Mood Disorders Psychopharmacol Unit, Toronto, ON, Canada.
   [Lipsitz, Orly; McIntyre, Roger S.; Rodrigues, Nelson B.; Lee, Yena; Gill, Hartej; Subramaniapillai, Mehala; Kratiuk, Kevin; Rosenblat, Joshua D.] Canadian Rapid Treatment Ctr Excellence, Mississauga, ON, Canada.
   [McIntyre, Roger S.; Rosenblat, Joshua D.] Brain & Cognit Discovery Fdn, Toronto, ON, Canada.
   [McIntyre, Roger S.; Mansur, Rodrigo B.; Rosenblat, Joshua D.] Univ Toronto, Dept Psychiat, Toronto, ON, Canada.
   [Kratiuk, Kevin] Poznan Univ Med Sci, Dept Clin Immunol, Poznan, Poland.
C3 University of Toronto; University Health Network Toronto; University of
   Toronto; Poznan University of Medical Sciences
RP McIntyre, RS (corresponding author), Univ Hlth Network, Mood Disorders Psychopharmacol Unit, Toronto, ON, Canada.; McIntyre, RS (corresponding author), Canadian Rapid Treatment Ctr Excellence, Mississauga, ON, Canada.; McIntyre, RS (corresponding author), Brain & Cognit Discovery Fdn, Toronto, ON, Canada.; McIntyre, RS (corresponding author), Univ Toronto, Dept Psychiat, Toronto, ON, Canada.
EM roger.mcintyre@uhn.ca
RI McIntyre, Roger/AAU-1000-2020; Mansur, Rodrigo/N-7131-2019; Gill,
   Hartej/AAA-3576-2022
OI Lipsitz, Orly/0000-0001-9110-7951
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NR 49
TC 13
Z9 13
U1 0
U2 2
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
SN 1092-8529
EI 2165-6509
J9 CNS SPECTRUMS
JI CNS Spectr.
PD JUN
PY 2022
VL 27
IS 3
BP 322
EP 330
AR PII S1092852920002102
DI 10.1017/S1092852920002102
PG 9
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA 1K8PI
UT WOS:000798857500014
PM 33267928
DA 2025-06-11
ER

PT J
AU Yeh, TC
   Liu, CP
   Cheng, WH
   Chen, BR
   Lu, PJ
   Cheng, PW
   Ho, WY
   Sun, GC
   Liou, JC
   Tseng, CJ
AF Yeh, Tung-Chen
   Liu, Chun-Peng
   Cheng, Wen-Han
   Chen, Bo-Rong
   Lu, Pei-Jung
   Cheng, Pei-Wen
   Ho, Wen-Yu
   Sun, Gwo-Ching
   Liou, Jau-Cheng
   Tseng, Ching-Jiunn
TI Caffeine Intake Improves Fructose-Induced Hypertension and Insulin
   Resistance by Enhancing Central Insulin Signaling
SO HYPERTENSION
LA English
DT Article
ID NITRIC-OXIDE SYNTHASE; NUCLEUS-TRACTUS-SOLITARII; BLOOD-PRESSURE;
   OXIDATIVE STRESS; FED RATS; METABOLIC SYNDROME; GENE-EXPRESSION;
   DRINKING RATS; DIABETIC-RATS; NADPH OXIDASE
C1 [Yeh, Tung-Chen; Liu, Chun-Peng] Kaohsiung Vet Gen Hosp, Div Cardiol, Dept Internal Med, Kaohsiung 813, Taiwan.
   [Cheng, Wen-Han; Chen, Bo-Rong; Cheng, Pei-Wen; Tseng, Ching-Jiunn] Kaohsiung Vet Gen Hosp, Dept Med Educ & Res, Kaohsiung 813, Taiwan.
   [Yeh, Tung-Chen; Liou, Jau-Cheng] Natl Sun Yat Sen Univ, Dept Biol Sci, Kaohsiung 80424, Taiwan.
   [Cheng, Wen-Han; Tseng, Ching-Jiunn] Natl Yang Ming Univ, Inst Clin Med, Taipei 112, Taiwan.
   [Lu, Pei-Jung; Sun, Gwo-Ching] Natl Cheng Kung Univ, Inst Clin Med, Tainan 70101, Taiwan.
   [Ho, Wen-Yu] Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Internal Med, Div Gen Internal Med, Kaohsiung, Taiwan.
   [Sun, Gwo-Ching] Yuli Vet Hosp, Dept Anesthesiol, Hualien, Taiwan.
   [Tseng, Ching-Jiunn] Natl Def Med Ctr, Dept Pharmacol, Taipei, Taiwan.
   [Tseng, Ching-Jiunn] Natl Sun Yat Sen Univ, Inst Biomed Sci, Kaohsiung 80424, Taiwan.
C3 Kaohsiung Veterans General Hospital; Kaohsiung Veterans General
   Hospital; National Sun Yat Sen University; National Yang Ming Chiao Tung
   University; National Cheng Kung University; Kaohsiung Medical
   University; Kaohsiung Medical University Hospital; National Defense
   Medical Center; National Sun Yat Sen University
RP Tseng, CJ (corresponding author), Kaohsiung Vet Gen Hosp, Dept Med Educ & Res, 386 Ta Chung 1st Rd, Kaohsiung 813, Taiwan.
EM netliou@mail.nsysu.edu.tw; cjtseng@vghks.gov.tw
RI Li, Jenny/GSD-3780-2022; Cheng, Wen-Han/I-6377-2012
FU National Science Council [NSC95-2320-B-075B-002, NSC100-2321-B-075B-002,
   NSC101-2320-B-075B-002-MY3]; Kaohsiung Veterans General Hospital
   [VGHKS97-080, VGHKS98-099]
FX This work was supported by funding from the National Science Council
   (NSC95-2320-B-075B-002, NSC100-2321-B-075B-002,
   NSC101-2320-B-075B-002-MY3) and Kaohsiung Veterans General Hospital
   (VGHKS97-080, VGHKS98-099) provided to C.-J. Tseng.
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NR 41
TC 40
Z9 44
U1 0
U2 16
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0194-911X
EI 1524-4563
J9 HYPERTENSION
JI Hypertension
PD MAR
PY 2014
VL 63
IS 3
BP 535
EP 541
DI 10.1161/HYPERTENSIONAHA.113.02272
PG 7
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA AA8GN
UT WOS:000331333700035
PM 24366086
OA Bronze
DA 2025-06-11
ER

PT J
AU Branth, S
   Ronquist, G
   Stridsberg, M
   Harnbraeus, L
   Kindgren, E
   Olsson, R
   Cartander, D
   Arnetz, B
AF Branth, Stefan
   Ronquist, Gunnar
   Stridsberg, Mats
   Harnbraeus, Leif
   Kindgren, Erik
   Olsson, Roger
   Cartander, David
   Arnetz, Bengt
TI Development of abdominal fat and incipient metabolic syndrome in young
   healthy men exposed to long-term stress
SO NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
LA English
DT Article
DE blood pressure; metabolic syndrome; obesity; nutrition; stress
ID INSULIN-RESISTANCE ATHEROSCLEROSIS; PSYCHOSOCIAL STRESS; CARDIOVASCULAR
   RISK; OBESITY; BODY; WOMEN; SENSITIVITY; CORTISOL; DISEASE; DIET
AB Background and aim: The sympathetic nervous system may be involved in the pathophysiology of insulin resistance and metabolic cardiovascular syndrome in young men. The aim was to study the effects of tong-term stress on different features of the metabolic syndrome (MES) in formerly non-obese healthy young mates during 5 months of defined conditions.
   Methods and results: Sixteen healthy male sailors (mean age 36.5 (SD) +/- 7 years) participating in a sailing race around the world were recruited for the study. Investigations were done before the start and at stopovers after finishing taps 1, 2 and 4 (1, 2 1/2 and 5 months, respectively). Anthropometric and blood pressure data as well as biochemical data associated with MES were substantiated. Food intake and exercise were chartered and largely controlled. A mean weight loss of 4.5 +/- 2 kg (P < 0.005), comprising both fat and lean body mass, was recorded during the first tap. Subsequently after 5 months, a weight gain, mainly consisting of 1.2 +/- 1.1 kg body fat (P < 0.05), took place, concomitantly with a protein mass drop of 0.6 +/- 1.1 kg (P < 0.05). The body fat gain accumulated on the abdominal region. Elevated blood levels of HbA1c, insulin and the triglycerides/high-density lipoprotein ratio were also observed during the race. Likewise heart rate and systolic blood pressure increased slightly but to a statistically significant extent.
   Conclusions: Non-obese healthy young men exposed to tong-term stress developed abdominal obesity and signs of a metabolic syndrome in embryo, also emphasized by biochemical and blood pressure alterations. It is suggested that tong-term and sustained stress activation might be an additional risk factor for the development of MES, even after control of dietary and exercise habits. (C) 2006 Elsevier B.V. All rights reserved.
C1 Uppsala Univ, Univ Uppsala Hosp, Sect Nutr, Dept Med Sci, SE-75185 Uppsala, Sweden.
   Univ Uppsala Hosp, Clin Chem, Dept Med Sci, SE-75185 Uppsala, Sweden.
   Karolinska Inst, Dept Biosci & Nutr, Unit Prevent Nutr, SE-14157 Huddinge, Sweden.
   Uppsala Univ, Univ Uppsala Hosp, Dept Publ Hlth & Caring Sci, Sect Social Med, SE-75185 Uppsala, Sweden.
C3 Uppsala University; Uppsala University Hospital; Uppsala University;
   Uppsala University Hospital; Karolinska Institutet; Uppsala University;
   Uppsala University Hospital
RP Branth, S (corresponding author), Uppsala Univ, Univ Uppsala Hosp, Sect Nutr, Dept Med Sci, SE-75185 Uppsala, Sweden.
EM stefan.branth@medsci.uu.se
RI Arnetz, Bengt/G-1685-2011; Kindgren, Erik/G-3837-2017
OI Kindgren, Erik/0000-0001-8023-1914
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NR 44
TC 47
Z9 52
U1 0
U2 4
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0939-4753
J9 NUTR METAB CARDIOVAS
JI Nutr. Metab. Carbiovasc. Dis.
PD JUL
PY 2007
VL 17
IS 6
BP 427
EP 435
DI 10.1016/j.numecd.2006.03.001
PG 9
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism; Nutrition
   & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism;
   Nutrition & Dietetics
GA 214BT
UT WOS:000249711700003
PM 17134957
DA 2025-06-11
ER

PT J
AU Tain, YL
   Lin, YJ
   Hsu, CN
AF Tain, You-Lin
   Lin, Ying-Jui
   Hsu, Chien-Ning
TI Animal Models for Studying Developmental Origins of
   Cardiovascular-Kidney-Metabolic Syndrome
SO BIOMEDICINES
LA English
DT Review
DE animal model; developmental origins of health and disease (DOHaD);
   oxidative stress; microbiota; cardiovascular disease; metabolic
   syndrome; renin-angiotensin system; kidney disease; nitric oxide;
   epigenetic regulation
ID RENIN-ANGIOTENSIN SYSTEM; MATERNAL NICOTINE EXPOSURE; INCREASES
   BLOOD-PRESSURE; REDUCES NEPHRON NUMBER; IN-UTERO EXPOSURE; LOW-PROTEIN
   DIET; HIGH-FAT-DIETS; OXIDATIVE STRESS; PRENATAL EXPOSURE; INSULIN
   SENSITIVITY
AB Cardiovascular-kidney-metabolic syndrome (CKMS) has become a significant global health challenge. Since CKMS often originates early in life, as outlined by the developmental origins of health and disease (DOHaD) concept, prevention is a more effective strategy than treatment. Various animal models, classified by environmental exposures or mechanisms, are used to explore the developmental origins of CKMS. However, no single model can fully replicate all aspects of CKMS or its clinical stages, limiting the advancement of preventive and therapeutic strategies. This review aims to assist researchers by comparing the strengths and limitations of common animal models used in CKMS programming studies and highlighting key considerations for selecting suitable models.
C1 [Tain, You-Lin] Kaohsiung Chang Gung Mem Hosp, Div Pediat Nephrol, Kaohsiung 833, Taiwan.
   [Tain, You-Lin] Chang Gung Univ, Coll Med, Taoyuan 333, Taiwan.
   [Tain, You-Lin] Kaohsiung Municipal Tatung Hosp, Dept Pediat, Kaohsiung 801, Taiwan.
   [Lin, Ying-Jui] Kaohsiung Chang Gung Mem Hosp, Div Crit Care, Dept Pediat, Kaohsiung 833, Taiwan.
   [Lin, Ying-Jui] Chang Gung Univ, Coll Med, Kaohsiung 833, Taiwan.
   [Lin, Ying-Jui] Kaohsiung Chang Gung Mem Hosp, Dept Pediat, Div Cardiol, Kaohsiung 833, Taiwan.
   [Lin, Ying-Jui] Kaohsiung Chang Gung Mem Hosp, Dept Resp Therapy, Kaohsiung 833, Taiwan.
   [Lin, Ying-Jui] Cheng Shiu Univ, Dept Early Childhood Care & Educ, Kaohsiung 833, Taiwan.
   [Hsu, Chien-Ning] Kaohsiung Chang Gung Mem Hosp, Dept Pharm, Kaohsiung 833, Taiwan.
   [Hsu, Chien-Ning] Kaohsiung Med Univ, Sch Pharm, Kaohsiung 807, Taiwan.
   [Hsu, Chien-Ning] Kaohsiung Municipal Tatung Hosp, Dept Pharm, Kaohsiung 801, Taiwan.
C3 Chang Gung Memorial Hospital; Chang Gung University; Kaohsiung Medical
   University; Kaohsiung Municipal Ta-Tung Hospital; Chang Gung Memorial
   Hospital; Chang Gung University; Chang Gung Memorial Hospital; Chang
   Gung Memorial Hospital; Cheng Shiu University; Chang Gung Memorial
   Hospital; Kaohsiung Medical University; Kaohsiung Medical University;
   Kaohsiung Municipal Ta-Tung Hospital
RP Hsu, CN (corresponding author), Kaohsiung Chang Gung Mem Hosp, Dept Pharm, Kaohsiung 833, Taiwan.; Hsu, CN (corresponding author), Kaohsiung Med Univ, Sch Pharm, Kaohsiung 807, Taiwan.; Hsu, CN (corresponding author), Kaohsiung Municipal Tatung Hosp, Dept Pharm, Kaohsiung 801, Taiwan.
EM tainyl@cgmh.org.tw; rayray@cgmh.org.tw; cnhsu@cgmh.org.tw
RI Hsu, Chien-Ning/GLS-4014-2022; Tain, You-Lin/H-2827-2019
OI Hsu, Chien-Ning/0000-0001-7470-528X; Tain, You-Lin/0000-0002-7059-6407
FU National Science and Technology Council, Taiwan;  [113-2314-B-182A-118]
FX This work was supported by the National Science and Technology Council,
   Taiwan, under grant number 113-2314-B-182A-118.
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NR 207
TC 1
Z9 1
U1 0
U2 0
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2227-9059
J9 BIOMEDICINES
JI Biomedicines
PD FEB
PY 2025
VL 13
IS 2
AR 452
DI 10.3390/biomedicines13020452
PG 21
WC Biochemistry & Molecular Biology; Medicine, Research & Experimental;
   Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Research & Experimental Medicine;
   Pharmacology & Pharmacy
GA Y2Q6H
UT WOS:001430637700001
PM 40002865
OA gold
DA 2025-06-11
ER

PT J
AU Vessières, E
   de Chantemèle, EJB
   Toutain, B
   Guihot, AL
   Jardel, A
   Loufrani, L
   Henrion, D
AF Vessieres, Emilie
   de Chantemele, Eric J. Belin
   Toutain, Bertrand
   Guihot, Anne-Laure
   Jardel, Alain
   Loufrani, Laurent
   Henrion, Daniel
TI Cyclooxygenase-2 inhibition restored endothelium-mediated relaxation in
   old obese Zucker rat mesenteric arteries
SO FRONTIERS IN PHYSIOLOGY
LA English
DT Article
DE resistance arteries; metabolic syndrome; cyclooxygenase-2; aging;
   vasodilatation; endothelium
ID SKELETAL-MUSCLE ARTERIOLES; IMPAIRED NITRIC-OXIDE; RESISTANCE ARTERIES;
   METABOLIC SYNDROME; ANGIOTENSIN-II; FUNCTIONAL VASODILATION;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; DIABETIC FATTY; BLOOD-FLOW
AB Metabolic syndrome is associated with reduced endothelial vasodilator function. It is also associated with the induction of cyclooxygenase-2 (COX2), which produces vasoactive prostanoids. The frequency of metabolic syndrome increases with age and aging per se is a risk factor associated with reduced endothelium-mediated relaxation. Nevertheless, the combined effect of aging and metabolic syndrome on the endothelium is less known. We hypothesized that COX2 derived prostanoids may affect endothelium function in metabolic syndrome associated with aging. We used obese Zucker rats, a model of metabolic syndrome. First order mesenteric arteries were isolated from 4- and 12-month-old rats and acetylcholine (endothelium)-dependent relaxation determined using wire-myography. Endothelium-mediated relaxation, impaired in young Zucker rats (89 versus 77% maximal relaxation; lean versus Zucker), was further reduced in old Zucker rats (72 versus 51%, lean versus Zucker). The effect of the nitric oxide-synthesis inhibitor L-NAME on the relaxation was reduced in both young and old Zucker rats without change in eNOS expression level. COX inhibition (indomethacin) improved acetylcholine-mediated relaxation in old obese rats only, suggesting involvement of vasoconstrictor prostanoids. In addition, COX2 inhibition (NS398) and TxA2/PGH2 receptor blockade (SQ29548) both improved relaxation in old Zucker rat arteries. Old Zucker rats had the highest TxB2 (TxA2 metabolite) blood level associated with increased COX2 immunostaining. Chronic COX2 blockade (Celecoxib, 3 weeks) restored endothelium-dependent relaxation in old Zucker rats to the level observed in old lean rats. Thus the combination of aging and metabolic syndrome further impairs endothelium-dependent relaxation by inducing an excessive production of COX2-derived vasoconstrictor(s); possibly TxA2.
C1 [Vessieres, Emilie; de Chantemele, Eric J. Belin; Toutain, Bertrand; Guihot, Anne-Laure; Loufrani, Laurent; Henrion, Daniel] Univ Angers, CNRS, UMR 6214, Angers, France.
   [Vessieres, Emilie; de Chantemele, Eric J. Belin; Toutain, Bertrand; Guihot, Anne-Laure; Henrion, Daniel] Univ Angers, Inst Natl Sante & Rech, U771, Angers, France.
   [Toutain, Bertrand; Jardel, Alain] Univ Angers, Integrated Neurovasc Biol, Angers, France.
   [Henrion, Daniel] Ctr Hosp Univ Angers, Angers, France.
C3 Centre National de la Recherche Scientifique (CNRS); Universite
   d'Angers; Universite d'Angers; Institut National de la Sante et de la
   Recherche Medicale (Inserm); Universite d'Angers; Universite d'Angers;
   Centre Hospitalier Universitaire d'Angers
RP Henrion, D (corresponding author), INSERM 771, Fac Med, UMR CNRS 6214, Dept Integrated Neurovasc Biol, F-49045 Angers, France.
EM daniel.henrion@univ-angers.fr
RI loufrani, laurent/K-1713-2015; de Chantemele, Eric/H-8923-2019; Henrion,
   Daniel/N-7023-2015; Toutain, Bertrand/M-1982-2015; vessieres,
   emilie/K-1894-2015; Henrion, Daniel/J-8141-2015
OI Henrion, Daniel/0000-0003-1094-0285; Belin de Chantemele, Eric
   J./0000-0002-0184-3830; Toutain, Bertrand/0000-0002-7571-4062
FU Foundation for Medical Research (FRM: Fondation pour la Recherche
   Medicale), Paris, France
FX We thank the local Animal Care Unit of the University of Angers and
   Jerome Roux, Pierre Legras, Dominique Gilbert for their kind help in
   treating the rats. Supports: Foundation for Medical Research (FRM:
   Fondation pour la Recherche Medicale), Paris, France. Eric J. Belin de
   Chantemele was a post-doctoral fellow of the Centre National d'Etudes
   Spatiales (CNES), France.
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NR 58
TC 30
Z9 34
U1 0
U2 4
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-042X
J9 FRONT PHYSIOL
JI Front. Physiol.
PY 2010
VL 1
AR 145
DI 10.3389/fphys.2010.00145
PG 10
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA V35UB
UT WOS:000209172400041
PM 21423385
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Grabia, M
   Socha, K
   Bossowski, A
   Markiewicz-Zukowska, R
AF Grabia, Monika
   Socha, Katarzyna
   Bossowski, Artur
   Markiewicz-Zukowska, Renata
TI Metabolic Syndrome as a Factor of Impairment of Antioxidant Defense
   System in Youth with T1DM
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE adolescents; diabetes mellitus type 1; metabolic syndrome; antioxidant
   enzymes; antioxidant status; dyslipidemia; hypertension; obesity;
   continuous glucose monitoring; biomarkers
ID SCHOOL-AGED CHILDREN; OXIDATIVE STRESS; INSULIN-RESISTANCE; ADOLESCENTS
AB Research indicates that adolescents with type 1 diabetes mellitus (T1DM) may develop both metabolic syndrome (MetS) and oxidative stress. The purpose of this study was to test the hypothesis that MetS could potentially affect antioxidant defense parameters. The study recruited adolescents aged 10-17 who had been diagnosed with T1DM, and divided them into two groups: "MetS+" (n = 22), who had been diagnosed with MetS, and "MetS-" (n = 81), who did not have metabolic syndrome. A control group consisting of 60 healthy peers without T1DM was included for comparison. The study examined cardiovascular parameters, such as complete lipid profile and estimated glucose disposal rate (eGDR), as well as markers of antioxidant defense. The results revealed a statistically significant difference between the MetS+ and the MetS- group in terms of total antioxidant status (TAS) (1.186 mmol/L vs. 1.330 mmol/L), and oxidative stress index (OSI) levels (0.666 vs. 0.533). Furthermore, multivariate correspondence analysis identified individuals with HbA1c < 8%; eGDR > 8 mg/kg/min, using either flash or continuous glucose monitoring systems, as MetS- patients. The study also found that eGDR (AUC 0.85, p < 0.001), OSI and HbA1c (AUC 0.71, p < 0.001) markers may be useful for diagnosing the onset of MetS in adolescents with T1DM.
C1 [Grabia, Monika; Socha, Katarzyna; Markiewicz-Zukowska, Renata] Med Univ Bialystok, Fac Pharm, Dept Bromatol, Div Lab Med, Mickiewicza 2D St, PL-15222 Bialystok, Poland.
   [Bossowski, Artur] Childrens Univ Clin Hosp Bialystok, Clin Pediat Endocrinol Diabetol, Subdiv Cardiol, Waszyngtona 17 St, PL-15274 Bialystok, Poland.
C3 Medical University of Bialystok
RP Markiewicz-Zukowska, R (corresponding author), Med Univ Bialystok, Fac Pharm, Dept Bromatol, Div Lab Med, Mickiewicza 2D St, PL-15222 Bialystok, Poland.
EM monika.grabia.diet@gmail.com; renmar@poczta.onet.pl
RI Grabia-Lis, Monika/AAQ-3817-2021; Bossowski, Artur/AAF-2127-2021
OI Markiewicz Zukowska, Renata/0000-0003-0716-9573; Grabia-Lis,
   Monika/0000-0002-2230-9143; Bossowski, Artur/0000-0002-6316-5342; Socha,
   Katarzyna/0000-0002-5949-7061
FU Medical University of Bialystok [SUB/2/DN/22/005/2216, B.SUB.23.406]
FX This research was funded by the Medical University of Bialystok, grant
   number SUB/2/DN/22/005/2216 and B.SUB.23.406.
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NR 37
TC 2
Z9 2
U1 0
U2 5
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD MAY 29
PY 2023
VL 24
IS 11
AR 9428
DI 10.3390/ijms24119428
PG 12
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA I7IM8
UT WOS:001004486200001
PM 37298384
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Casagrande, BP
   Ribeiro, AM
   Pisani, LP
   Estadella, D
AF Casagrande, Breno Picin
   Ribeiro, Alessandra Mussi
   Pisani, Luciana Pellegrini
   Estadella, Debora
TI Hippocampal BDNF mediated anxiety-like behaviours induced by obesogenic
   diet withdrawal
SO BEHAVIOURAL BRAIN RESEARCH
LA English
DT Article
DE Anxiety; BDNF; Hippocampus; Obesogenic diet; Withdrawal
ID HIGH-FAT DIET; NEUROTROPHIC FACTOR; METABOLIC SYNDROME;
   HIGH-CARBOHYDRATE; CHRONIC EXPOSURE; PALATABLE DIET; SATURATED-FAT;
   STRESS; SUGAR; RATS
AB Obesogenic diets (ODs) consumption is associated with anxiety-like behaviour and negative changes in hippocampal BDNF. At the same time, interrupting OD intake, OD withdrawal (WTD), can bring health benefits, but previous studies reported the development of anxiety-like behaviours. The present work aimed to assess the relationship between anxiety-like behaviour with hippocampal BDNF in a WTD rodent model. Male Wistar rats (60d old) were fed a high-sugar/high-fat (HSHF) diet for 30d (n = 32), and half of them were transitioned to a control diet for 48 h (n = 16) afterwards. The control group (n = 16) was fed a control diet across the whole experiment. Besides increasing anxiety-like behaviours and lowering sociability, the WTD led to an increase in BDNF in the dentate gyrus and the CA1 of the hippocampus. It also decreased locomotor activity in both OF and EPM, however, they did not significantly interfere with the other behavioural parameters analysed. Western blotting analysis revealed that the increase in BDNF likely occurred in the mature forms (14 kD monomer and 28 kD dimer). The mediation models analyses suggested that the effect of WTD on anxiety-like behaviour was driven by hippocampal BDNF, this mediation of effect was region-dependent. Our results also suggested that mature BDNF forms (14 kD and 28 kD) were responsible. The present work brought light to a possible new role for mature BDNF, although it is generally associated with beneficial features, it can also be part of the genesis of anxiety-like behaviours and sociability aspects on WTD models.
C1 [Casagrande, Breno Picin; Ribeiro, Alessandra Mussi; Pisani, Luciana Pellegrini; Estadella, Debora] Univ Fed Sao Paulo, Inst Hlth & Soc, Biosci Dept, BR-1015020 Santos, SP, Brazil.
   [Estadella, Debora] Univ Fed Sao Paulo, Inst Hlth & Soc, Biosci Dept, Campus Baixada Santista UNIFESP BS, BR-11015020 Santos, SP, Brazil.
C3 Universidade Federal de Sao Paulo (UNIFESP); Universidade Federal de Sao
   Paulo (UNIFESP)
RP Estadella, D (corresponding author), Univ Fed Sao Paulo, Inst Hlth & Soc, Biosci Dept, Campus Baixada Santista UNIFESP BS, BR-11015020 Santos, SP, Brazil.
EM brenopcasagrande@gmail.com; alemrib@gmail.com; lucianapisani@gmail.com;
   estadella@unifesp.br
RI Pisani, Luciana/B-3038-2015; Estadella, Debora/G-5817-2012; Ribeiro,
   Alessandra/G-1597-2012; Casagrande, Breno/Y-1442-2019
OI Pisani, Luciana/0000-0001-6579-6167; Mussi Ribeiro,
   Alessandra/0000-0002-7697-5766; Picin Casagrande,
   Breno/0000-0001-9478-8262
FU 'Sao Paulo Research Foundation' (FAPESP) [2017/25420-3]; 'Coordination
   for the Improvement of Higher Education Personnel' (CAPES Brazil) [001];
   CNPq; FAPESP [2019/22511-3]
FX This work was supported in part by the 'Sao Paulo Research Foundation'
   (FAPESP #2017/25420-3) and by the 'Coordination for the Improvement of
   Higher Education Personnel' (CAPES Brazil - Financial Code 001). LPP is
   a beneficiary of the "National Council for Scientific and Technological
   Development" (CNPq) productivity fellowship. BPC is a Ph.D. scholarship
   recipient from FAPESP (#2019/22511-3).
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NR 65
TC 7
Z9 8
U1 1
U2 8
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0166-4328
EI 1872-7549
J9 BEHAV BRAIN RES
JI Behav. Brain Res.
PD JAN 5
PY 2023
VL 436
AR 114077
DI 10.1016/j.bbr.2022.114077
EA SEP 2022
PG 9
WC Behavioral Sciences; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Behavioral Sciences; Neurosciences & Neurology
GA 6G4AE
UT WOS:000884695500008
PM 36041572
DA 2025-06-11
ER

PT J
AU Xia, JL
   Ding, L
   Liu, GY
AF Xia, Jiali
   Ding, Li
   Liu, Guoyan
TI Metabolic syndrome and dermatological diseases: association and
   treatment
SO NUTRITION & METABOLISM
LA English
DT Review
DE Metabolic syndrome; Dermatological diseases; Insulin resistance; Chronic
   inflammation; Oxidative stress; Lipid metabolism
ID ONSET ANDROGENETIC ALOPECIA; CARDIOVASCULAR RISK-FACTORS;
   POLYCYSTIC-OVARY-SYNDROME; BODY-MASS INDEX; INSULIN-RESISTANCE;
   ACANTHOSIS NIGRICANS; ATOPIC-DERMATITIS; HIDRADENITIS SUPPURATIVA;
   ENDOPLASMIC-RETICULUM; PSORIATIC PATIENTS
AB Metabolic syndrome (MetS) is a clinical syndrome associated with cardiovascular disease, diabetes, obesity, and dyslipidemia. Its primary features include dyslipidemia, hypertension, abdominal obesity, and insulin resistance (IR). Recently, research has revealed that MetS is not only a manifestation of internal metabolic disturbances but is also closely associated with various dermatological conditions, including inflammatory skin diseases, autoimmune skin diseases, and skin tumors. These studies have clarified the complex mechanisms underlying the interaction between MetS and these skin diseases, including IR, chronic inflammatory responses, and oxidative stress. This review summarizes the association between MetS and related dermatological conditions and their shared physiological mechanisms. It aims to provide clinicians with new therapeutic strategies and preventive measures to improve the treatment outcomes and quality of life of patients with skin conditions.
C1 [Xia, Jiali; Ding, Li] Xuzhou Med Univ, Affiliated Xuzhou Municipal Hosp, Dept Dermatol, Xuzhou, Peoples R China.
   [Liu, Guoyan] Shandong First Med Univ, Hosp Skin Dis, Jinan, Peoples R China.
   [Liu, Guoyan] Shandong Acad Med Sci, Shandong Prov Inst Dermatol & Venereol, Jinan, Peoples R China.
C3 Xuzhou Medical University; Shandong First Medical University & Shandong
   Academy of Medical Sciences; Shandong First Medical University &
   Shandong Academy of Medical Sciences; University of Jinan
RP Liu, GY (corresponding author), Shandong First Med Univ, Hosp Skin Dis, Jinan, Peoples R China.; Liu, GY (corresponding author), Shandong Acad Med Sci, Shandong Prov Inst Dermatol & Venereol, Jinan, Peoples R China.
EM wfliuguoyan@126.com
RI Xia, Jiali/IUM-4743-2023
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NR 230
TC 0
Z9 0
U1 0
U2 0
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1743-7075
J9 NUTR METAB
JI Nutr. Metab.
PD MAY 6
PY 2025
VL 22
IS 1
AR 36
DI 10.1186/s12986-025-00924-1
PG 21
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 2HL8S
UT WOS:001482755700001
PM 40329305
DA 2025-06-11
ER

PT J
AU Marycz, K
   Kornicka, K
   Szlapka-Kosarzewska, J
   Weiss, C
AF Marycz, Krzysztof
   Kornicka, Katarzyna
   Szlapka-Kosarzewska, Jolanta
   Weiss, Christine
TI Excessive Endoplasmic Reticulum Stress Correlates with Impaired
   Mitochondrial Dynamics, Mitophagy and Apoptosis, in Liver and Adipose
   Tissue, but Not in Muscles in EMS Horses
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE metabolic syndrome; apoptosis; insulin resistance; mitochondria;
   autophagy
ID EQUINE METABOLIC SYNDROME; BINDING-PROTEIN 4; INSULIN-RESISTANCE;
   OXIDATIVE STRESS; INFLAMMATORY RESPONSES; DIABETES-MELLITUS;
   GENE-EXPRESSION; OBESITY; FISSION; COMPLICATIONS
AB Nowadays, endocrine disorders have become more frequent in both human and veterinary medicine. In horses, reduced physical activity combined with carbohydrate and sugar overload may result in the development of the so-called equine metabolic syndrome (EMS). EMS is characterized by insulin resistance, hyperinsulinemia, elevated blood triglyceride concentrations and usually obesity. Although the phenotypic features of EMS individuals are well known, the molecular mechanism underlying disease development remains elusive. Therefore, in the present study, we analyzed insulin-sensitive tissues, i.e., muscles, liver and adipose tissue in order to evaluate insulin resistance and apoptosis. Furthermore, we assessed mitochondrial dynamics and mitophagy in those tissues, because mitochondrial dysfunction is linked to the development of metabolic syndrome. We established the expression of genes related to insulin resistance, endoplasmic reticulum (ER) stress and mitochondria clearance by mitophagy using RT-PCR and Western blot. Cell ultrastructure was visualized using electron transmission microscopy. The results indicated that adipose tissue and liver of EMS horses were characterized by increased mitochondrial damage and mitophagy followed by triggering of apoptosis as mitophagy fails to restore cellular homeostasis. However, in muscles, apoptosis was reduced, suggesting the existence of a protective mechanism allowing that tissue to maintain homeostasis.
C1 [Marycz, Krzysztof; Kornicka, Katarzyna; Szlapka-Kosarzewska, Jolanta] Wroclaw Univ Environm & Life Sci, Dept Expt Biol, PL-50375 Wroclaw, Poland.
   [Marycz, Krzysztof] Wroclaw Res Ctr EIT, Ul Stablowicka 147, PL-54066 Wroclaw, Poland.
   [Weiss, Christine] PferdePraxis Dr Med Vet Daniel Weiss, Postmatte 14, CH-8807 Freienbach, Switzerland.
C3 Wroclaw University of Environmental & Life Sciences
RP Marycz, K (corresponding author), Wroclaw Univ Environm & Life Sci, Dept Expt Biol, PL-50375 Wroclaw, Poland.; Marycz, K (corresponding author), Wroclaw Res Ctr EIT, Ul Stablowicka 147, PL-54066 Wroclaw, Poland.
EM krzysztof.marycz@upwr.edu.pl; kornicka.katarzyna@gmail.com;
   jolanta.szlapka@gmail.com; d.weiss@horsedoc.ch
OI Marycz, Krzysztof/0000-0003-3676-796X
FU National Science Centre in Poland [2016/21/B/NZ7/01111]; Wroclaw Centre
   of Biotechnology Leading National Research Centre (KNOW) program
FX The study was financed by the National Science Centre in Poland Grant
   No. 2016/21/B/NZ7/01111. The publication was supported by the Wroclaw
   Centre of Biotechnology Leading National Research Centre (KNOW) program
   for years 2014-2018.
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NR 39
TC 58
Z9 58
U1 0
U2 9
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD JAN
PY 2018
VL 19
IS 1
AR 165
DI 10.3390/ijms19010165
PG 20
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA FV2OI
UT WOS:000424407200162
PM 29316632
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Midei, AJ
   Matthews, KA
   Chang, YF
   Bromberger, JT
AF Midei, Aimee J.
   Matthews, Karen A.
   Chang, Yue-Fang
   Bromberger, Joyce T.
TI Childhood Physical Abuse Is Associated With Incident Metabolic Syndrome
   in Mid-Life Women
SO HEALTH PSYCHOLOGY
LA English
DT Article
DE childhood abuse; metabolic syndrome; menopause
ID 3RD NATIONAL-HEALTH; CARDIOVASCULAR-DISEASE; HOUSEHOLD DYSFUNCTION;
   RISK-FACTORS; PATTERNS; STRESS; QUESTIONNAIRE; METAANALYSIS; PATHWAYS;
   DISORDER
AB Objective: Previous research has suggested that childhood emotional abuse, physical abuse, and sexual abuse are associated with an increased risk for ischemic heart disease. Our objective was to examine whether childhood abuse predicted incident metabolic syndrome, a precursor to heart disease, in midlife women. Methods: Participants were 342 (114 Black, 228 White) women from the Pittsburgh site of the Study of Women's Health Across the Nation (SWAN). SWAN included a baseline assessment of premenopausal or early perimenopausal women in midlife (mean age = 45.7), and women were evaluated for presence of the metabolic syndrome over 7 annual follow-up visits. Women were classified as having metabolic syndrome if they met 3 of the following criteria: waist circumference >88 cm, triglycerides >= 150 mg/dl, HDL <50 mg/dl, SBP >= 130 or DBP >= 85 mmHg or on blood pressure medication, and fasting glucose >= 110 mg/dl or diabetic. The Childhood Trauma Questionnaire is a standardized measure that retrospectively assesses 3 domains of abuse in childhood and adolescence: emotional, physical, and sexual abuse. Results: Approximately 34% of the participants reported a history of abuse. Cox model survival analysis showed that physical abuse was associated with incident metabolic syndrome over the course of 7 years (HR = 2.12, p = .02), adjusted for ethnicity, age at baseline, and time-dependent menopausal status. Sexual abuse and emotional abuse were unrelated to the metabolic syndrome. Conclusion: This is the first study to show that a history of childhood abuse, specifically physical abuse, is related to the development of metabolic syndrome in midlife women.
C1 [Midei, Aimee J.] Univ Pittsburgh, Dept Psychol, Pittsburgh, PA 15213 USA.
   [Matthews, Karen A.] Univ Pittsburgh, Dept Psychiat Psychol & Epidemiol, Pittsburgh, PA 15213 USA.
   [Chang, Yue-Fang] Univ Pittsburgh, Dept Neurol Surg, Pittsburgh, PA 15213 USA.
   [Bromberger, Joyce T.] Univ Pittsburgh, Dept Epidemiol & Psychiat, Pittsburgh, PA 15213 USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE); University
   of Pittsburgh; Pennsylvania Commonwealth System of Higher Education
   (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of
   Higher Education (PCSHE); University of Pittsburgh; Pennsylvania
   Commonwealth System of Higher Education (PCSHE); University of
   Pittsburgh
RP Matthews, KA (corresponding author), Univ Pittsburgh, Dept Psychiat, 3811 OHara St, Pittsburgh, PA 15213 USA.
EM matthewska@upmc.edu
OI bromberger, joyce/0000-0001-7101-3800
FU National Institutes of Health (NIH), Department of Health and Human
   Services, through the National Institute on Aging (NIA), the National
   Institute of Nursing Research (NINR); NIH Office of Research on Women's
   Health (ORWH) [NR004061, AG012505, AG012535, AG012531, AG012539,
   AG012546, AG012553, AG012554, AG012495]; National Institute of Mental
   Health [MH59689]
FX The Study of Women's Health Across the Nation (SWAN) has grant support
   from the National Institutes of Health (NIH), Department of Health and
   Human Services, through the National Institute on Aging (NIA), the
   National Institute of Nursing Research (NINR), and the NIH Office of
   Research on Women's Health (ORWH) (Grants NR004061; AG012505, AG012535,
   AG012531, AG012539, AG012546, AG012553, AG012554, AG012495).
   Supplemental funding from the National Institute of Mental Health
   (MH59689) is also gratefully acknowledged. The content of this article
   is solely the responsibility of the authors and does not necessarily
   represent the official views of the NIA, NINR, ORWH, or the NIH.
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NR 38
TC 64
Z9 76
U1 0
U2 26
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 0278-6133
EI 1930-7810
J9 HEALTH PSYCHOL
JI Health Psychol.
PD FEB
PY 2013
VL 32
IS 2
BP 121
EP 127
DI 10.1037/a0027891
PG 7
WC Psychology, Clinical; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology
GA 084JT
UT WOS:000314535900001
PM 22775234
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Versey, HS
   Tan, MX
AF Versey, H. Shellae
   Tan, Mingxuan
TI Work-family spillover and metabolic syndrome indicators: Findings from a
   national sample
SO JOURNAL OF HEALTH PSYCHOLOGY
LA English
DT Article
DE body mass index; longitudinal; metabolic syndrome; negative spillover;
   work-family conflict
ID MULTIPLE ROLES; CARDIOVASCULAR REACTIVITY; HEALTH OUTCOMES; EMPLOYEE
   HEALTH; BLOOD-PRESSURE; CHANGING WORK; LIFE COURSES; JOB STRAIN;
   CONFLICT; STRESS
AB This study examines the link between negative work-family spillover and metabolic risk factors over a 9-year period. Data from two waves of the Midlife in the United States Survey were used to explore relationships between negative work-family spillover and four indicators of metabolic syndrome-blood pressure, triglycerides, body mass index, and glucose levels. In a sample of full-time working men and women (N = 630), increased negative spillover at baseline significantly predicted higher body mass index nearly a decade later, with a marginally significant effect for triglyceride levels. Increases in spillover also body mass index and glucose levels at follow-up. This study extends research tying work-life spillover to health and suggests that further investigation is needed to fully understand the long-term effects of work stress.
C1 [Versey, H. Shellae; Tan, Mingxuan] Wesleyan Univ, Middletown, CT USA.
C3 Wesleyan University
RP Versey, HS (corresponding author), Wesleyan Univ, Dept Psychol, 207 High St,Judd Hall,Room 404, Middletown, CT USA.
EM sversey@wesleyan.edu
FU NIA NIH HHS [U19 AG051426, P01 AG020166] Funding Source: Medline
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NR 75
TC 8
Z9 9
U1 0
U2 13
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1359-1053
EI 1461-7277
J9 J HEALTH PSYCHOL
JI J. Health Psychol.
PD SEP
PY 2020
VL 25
IS 10-11
BP 1771
EP 1783
DI 10.1177/1359105318764014
PG 13
WC Psychology, Clinical
WE Social Science Citation Index (SSCI)
SC Psychology
GA NK8XJ
UT WOS:000567013400039
PM 29575934
DA 2025-06-11
ER

PT J
AU Mi, SY
   Gong, L
   Sui, ZQ
AF Mi, Shuyi
   Gong, Liang
   Sui, Ziqi
TI Friend or Foe? An Unrecognized Role of Uric Acid in Cancer Development
   and the Potential Anticancer Effects of Uric Acid-lowering Drugs
SO JOURNAL OF CANCER
LA English
DT Review
DE hyperuricemia; cancer risk; metabolic syndrome; liver metastasis; uric
   acid-lowering agents
ID INCREASED RISK; INSULIN-RESISTANCE; METABOLIC SYNDROME; HEPATIC
   STEATOSIS; OXIDATIVE STRESS; PROSTATE-CANCER; GOUT PATIENTS; ALL-CAUSE;
   LIVER; INFLAMMATION
AB In recent years, metabolic syndrome (Mets) has been a hot topic among medical scientists. Mets has an intimate relationship with the incidence and development of various cancers. As a contributory factor of Mets, hyperuricemia actually plays an inseparable role in the formation of various metabolic disorders. Although uric acid is classically considered an antioxidant with beneficial effects, mounting evidence indicates that a high serum uric acid (SUA) level may serve as a pro-oxidant to generate inflammatory reactions and oxidative stress. In this review, we describe the unrecognized role of hyperuricemia in cancer development and summarize major mechanisms linking uric acid to carcinogenesis. Furthermore, we also discuss the potential mechanism of liver metastasis of cancer and list some types of uric acid-lowering agents, which may exert anticancer effects.
C1 [Mi, Shuyi; Sui, Ziqi] First Peoples Hosp Yuhang Dist, Dept Gastroenterol, 369 Yingbin Rd, Hangzhou 310009, Zhejiang, Peoples R China.
   [Gong, Liang] Cixi Peoples Hosp, Dept Otolaryngol, Ningbo, Zhejiang, Peoples R China.
   [Mi, Shuyi] Zhejiang Univ City Coll, Sch Med, Hangzhou, Zhejiang, Peoples R China.
   [Sui, Ziqi] Jiamusi Univ, Coll Basic Med Sci, Dept Pathophysiol, Jiamusi, Heilongjiang, Peoples R China.
C3 Hangzhou City University; Jiamusi University
RP Sui, ZQ (corresponding author), First Peoples Hosp Yuhang Dist, Dept Gastroenterol, 369 Yingbin Rd, Hangzhou 310009, Zhejiang, Peoples R China.
EM wenqisui@jmsu.edu.cn
FU Health and Family Planning Commission of Zhejiang Province [2015RCB026]
FX This work was supported by grant from the Health and Family Planning
   Commission of Zhejiang Province (No. 2015RCB026).
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NR 97
TC 36
Z9 37
U1 1
U2 27
PU IVYSPRING INT PUBL
PI LAKE HAVEN
PA PO BOX 4546, LAKE HAVEN, NSW 2263, AUSTRALIA
SN 1837-9664
J9 J CANCER
JI J. Cancer
PY 2020
VL 11
IS 17
BP 5236
EP 5244
DI 10.7150/jca.46200
PG 9
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA MK9JR
UT WOS:000549096300029
PM 32742469
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Farah, R
   Gilbey, P
   Asli, H
   Khamisy-Farah, R
   Assy, N
AF Farah, R.
   Gilbey, P.
   Asli, H.
   Khamisy-Farah, R.
   Assy, N.
TI Antioxidant Enzyme Activity and Cognition in Obese Individuals with or
   without Metabolic Risk Factors
SO EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
LA English
DT Article
DE antioxidant; metabolic syndrome; healthy individuals; unhealthy;
   cognition; liver fibro scan
ID BODY-MASS INDEX; DEPRESSIVE SYMPTOMS; CARDIOVASCULAR-DISEASE;
   ALZHEIMER-DISEASE; ASSOCIATION; POPULATION; MORTALITY; ADULTS; MEN;
   PREVALENCE
AB Background: The metabolic syndrome may be associated with cognitive impairment and increased oxidative stress.
   Aim: To document the association between metabolic syndrome, cognitive impairment and oxidative stress activity in metabolically healthy obese and in metabolically unhealthy obese individuals.
   Methods: 60 obese individuals aged (4910 years, 52% male) were enrolled. Obesity was defined as BMI>30. Metabolic syndrome was defined according to ATP III guidelines. Obese individuals were divided into 2 groups: Group 1, metabolically healthy obese (2 components of metabolic syndrome), and Group 2, metabolically unhealthy obese (>2 components of metabolic syndrome). Cognitive dysfunction was determined by Montreal cognitive assessment score. Liver Fibro scan (Elastography), Inflammation (CRP), pro oxidants (MDA), antioxidant activity (SOD, PON, GSH, GPx) and insulin resistance (HOMA-IR) were measured.
   Results: Of the 30 metabolically unhealthy obese individuals, 13% developed dementia, 51% had mild cognitive impairment, and 36% had a normal cognitive score. In the metabolically healthy obese group, 3% developed dementia, 7% had mild cognitive impairment, and 90% had a normal cognitive score. There was a significant difference in liver stiffness (7 +/- 3 vs. 5.2 +/- 2.7kpa, p<0.001), liver fat measurement (337 +/- 51 vs. 280 +/- 20db/m, p<0.001), MDA (4.7 +/- 0.9 vs. 5.47 +/- 1.12mM, P<0.003), Glutathione GSH (27.2 +/- 2.4 vs. 28.4 +/- 2.3, P<0.03), CRP (9 +/- 6 vs. 7 +/- 6 P<0.001) and insulin resistance (2.5 +/- 1 vs. 6 +/- 5.5 p<0.02) between the 2 groups. Correlations were significant between GPx activity and liver stiffness (r=0.37), GPx activity and abdominal girth (r=-0.22) and glucose concentration and SOD activity (r=0.4). Multivariate analysis showed that HOMA-IR, MDA and GSH were the most powerful predictors of metabolically unhealthy obesity.
   Conclusion: There is a significant mild cognitive impairment and increased oxidative stress activity in the metabolically unhealthy obese. Whether treatment with anti-oxidants improves cognitive dysfunction remains to be determined.
C1 [Farah, R.; Asli, H.] Ziv Med Ctr, Dept Internal Med B, Rambam St, IL-13100 Safed, Israel.
   [Farah, R.; Gilbey, P.; Khamisy-Farah, R.; Assy, N.] Bar Ilan Univ, Fac Med Galilee, Safed, Israel.
   [Khamisy-Farah, R.] Women Hlth Care, Clalit Hlth Serv, Akko, Israel.
   [Assy, N.] Ziv Med Ctr, Liver Dis Unit, Safed, Israel.
C3 Ziv Medical Center; Bar Ilan University; Clalit Health Services; Ziv
   Medical Center
RP Farah, R (corresponding author), Ziv Med Ctr, Dept Internal Med B, Rambam St, IL-13100 Safed, Israel.
EM Raymond.f@ziv.health.gov.il
RI asli, Hamid/H-1433-2017; Farah, Raymond/LWJ-6661-2024
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NR 36
TC 11
Z9 12
U1 0
U2 4
PU JOHANN AMBROSIUS BARTH VERLAG MEDIZINVERLAGE HEIDELBERG GMBH
PI STUTTGART
PA RUEDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0947-7349
EI 1439-3646
J9 EXP CLIN ENDOCR DIAB
JI Exp. Clin. Endocrinol. Diabet.
PD OCT
PY 2016
VL 124
IS 9
BP 568
EP 571
DI 10.1055/s-0042-113125
PG 4
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA EA0XR
UT WOS:000386313300008
PM 27657994
DA 2025-06-11
ER

PT J
AU Moore, SM
   Welsh, MC
   Peterson, E
AF Moore, Susannah M.
   Welsh, Marilyn C.
   Peterson, Eric
TI Childhood maltreatment predicts physical health in college students
SO JOURNAL OF AMERICAN COLLEGE HEALTH
LA English
DT Article
DE Childhood maltreatment; emerging adults; heart rate; metabolic syndrome;
   obesity
ID POSTTRAUMATIC-STRESS-DISORDER; RESTING HEART-RATE; EARLY-LIFE STRESS;
   BODY-MASS INDEX; METABOLIC SYNDROME; CARDIOVASCULAR-DISEASE;
   BLOOD-PRESSURE; RISK-FACTORS; TRAUMA QUESTIONNAIRE; MODERATING ROLE
AB Objective Childhood maltreatment (CM) is associated with physical health problems throughout the lifespan, yet more research is needed regarding the trajectory of health problems (e.g., onset of health risk indicators) in young adults. The current study examined whether college students self-reporting higher levels of CM exhibited poorer physical health outcomes. Method: Young adults in college (N = 100) completed a physical health assessment (heart rate, body mass index (BMI), blood pressure, blood sugar, waist circumference), self-reported measures of health (symptoms of illness), and CM during spring semester 2018. Results: CM scores predicted higher heart rate and increased symptoms of illness. Females with maltreatment history presented higher levels of obesity and more metabolic syndrome conditions than their peers. Conclusions: Findings support the importance of examining the trajectory of CM to chronic disease, as health risk indicators are present in young adults.
C1 [Moore, Susannah M.; Welsh, Marilyn C.; Peterson, Eric] Univ Northern Colorado, Sch Psychol Sci, Greeley, CO USA.
C3 University of Northern Colorado
RP Moore, SM (corresponding author), Eastern Mennonite Univ, Dept Psychol, 1200 Pk RD, Harrisonburg, VA 22802 USA.
EM susannah.moore@emu.edu
FU Faculty Development grant from the University of the Northern Colorado
FX This research was supported by an internal Research, Dissemination, and
   Faculty Development grant from the University of the Northern Colorado.
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NR 74
TC 2
Z9 2
U1 1
U2 5
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 0744-8481
EI 1940-3208
J9 J AM COLL HEALTH
JI J. Am. Coll. Health
PD MAR 24
PY 2023
VL 71
IS 3
BP 942
EP 951
DI 10.1080/07448481.2021.1909047
EA MAR 2021
PG 10
WC Education & Educational Research; Public, Environmental & Occupational
   Health
WE Social Science Citation Index (SSCI)
SC Education & Educational Research; Public, Environmental & Occupational
   Health
GA F7OH3
UT WOS:000664073800001
PM 34152945
DA 2025-06-11
ER

PT J
AU Östh, J
   Diwan, V
   Jirwe, M
   Diwan, V
   Choudhary, A
   Mahadik, VK
   Pascoe, M
   Hallgren, M
AF Osth, Josefine
   Diwan, Vinod
   Jirwe, Maria
   Diwan, Vishal
   Choudhary, Anita
   Mahadik, Vijay Khanderao
   Pascoe, Michaela
   Hallgren, Mats
TI Effects of yoga on well-being and healthy ageing: study protocol for a
   randomised controlled trial (FitForAge)
SO BMJ OPEN
LA English
DT Article
ID PHYSICAL-ACTIVITY QUESTIONNAIRE; INSOMNIA SEVERITY INDEX; SWEDISH
   VERSION; OLDER-ADULTS; LIFE SATISFACTION; PSYCHOMETRIC PROPERTIES;
   SOCIAL RELATIONSHIPS; EXERCISE ADHERENCE; DEPRESSION SCALE; BALANCE
AB Introduction Due to ageing populations worldwide, the burden of disability is increasing. It is therefore important to develop interventions that improve healthy ageing, reduce disability onset and enhance life quality. Physical activity can promote healthy ageing and help maintain independence, yet many older adults are inactive. Yoga is a form of physical activity that aims to improve health and may be particularly suitable for older adults. Research indicates positive effects of yoga on several health-related outcomes; however, empirical studies examining the benefits of yoga on well-being among the elderly remain scarce. This study protocol reports the methodology for a 12-week yoga programme aimed to improve health and well-being among physically inactive older adults.
   Methods and analysis Three group parallel, single-blind randomised controlled trial. Two comparison groups are included: aerobic exercise and a non-active wait-list control. In total, 180 participants aged 65-85 years will be recruited. Assessments will be performed at baseline and postintervention (12-week follow-up). The primary outcome is subjective well-being. Secondary outcomes include physical activity/sedentary behaviour, mobility/fall risk, cognition, depression, anxiety, mood, stress, pain, sleep quality, social support and cardiometabolic risk factors. Data will be analysed using intention-to-treat analyses, with mixed linear modelling.
   Ethics and dissemination This study is approved by the Ethical Review Board in Stockholm (2017/1862-31/2). All participants must voluntarily agree to participate and are free to withdraw from the study at any point. Written informed consent will be obtained from each participant prior to inclusion. Results will be available through research articles and conferences. A summary of key results will be publicly available through newspaper articles.
C1 [Osth, Josefine; Hallgren, Mats] Karolinska Inst, Dept Publ Hlth Sci, Stockholm, Sweden.
   [Diwan, Vinod] Karolinska Inst, Dept Publ Hlth Sci, Solna, Sweden.
   [Jirwe, Maria] Sophiahemmet Hgsk, Dept Hlth Promoting Sci, Stockholm, Sweden.
   [Jirwe, Maria] Karolinska Inst, Dept Neurobiol Care Sci & Soc, Stockholm, Sweden.
   [Diwan, Vishal] Ruxmaniben Deepchand Gardi Med Coll, Dept Publ Hlth & Environm, Int Ctr Hlth Res, Ujjain, Madhya Pradesh, India.
   [Choudhary, Anita; Mahadik, Vijay Khanderao] Ruxmaniben Deepchand Gardi Med Coll, Dept Physiol, Ujjain, Madhya Pradesh, India.
   [Pascoe, Michaela] Victoria Univ, Inst Hlth & Sport, Melbourne, Vic, Australia.
C3 Karolinska Institutet; Karolinska Institutet; Karolinska Institutet;
   Victoria University
RP Hallgren, M (corresponding author), Karolinska Inst, Dept Publ Hlth Sci, Stockholm, Sweden.
EM mats.hallgren@ki.se
RI Jirwe, Maria/AAW-3427-2021
OI Diwan, Vishal/0000-0001-7948-8579; Pascoe, Michaela/0000-0002-3831-5660;
   Osth, Josefine/0000-0001-7512-804X; Diwan, Vinod/0000-0002-5831-2037
FU Swedish Research Council for Health, Working Life and Welfare (FORTE)
   [2017-00024]; Formas [2017-00024] Funding Source: Formas; Forte
   [2017-00024] Funding Source: Forte; Vinnova [2017-00024] Funding Source:
   Vinnova
FX This study is supported by Swedish Research Council for Health, Working
   Life and Welfare (FORTE), grant number 2017-00024 awarded to MH. The
   funding body will play no role in the design and/or conduct of the
   study.
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NR 75
TC 22
Z9 22
U1 1
U2 55
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2044-6055
J9 BMJ OPEN
JI BMJ Open
PD MAY
PY 2019
VL 9
IS 5
AR e027386
DI 10.1136/bmjopen-2018-027386
PG 9
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA IC7YG
UT WOS:000471192800274
PM 31147363
OA Green Published, Green Accepted, gold
DA 2025-06-11
ER

PT J
AU Damme, KSF
   Vargas, TG
   Walther, S
   Shankman, SA
   Mittal, VA
AF Damme, Katherine S. F.
   Vargas, Teresa G.
   Walther, Sebastian
   Shankman, Stewart A.
   Mittal, Vijay A.
TI Physical and mental health in adolescence: novel insights from a
   transdiagnostic examination of FitBit data in the ABCD study
SO TRANSLATIONAL PSYCHIATRY
LA English
DT Article
ID CLINICAL HIGH-RISK; ULTRA-HIGH-RISK; SEDENTARY BEHAVIOR;
   CARDIORESPIRATORY FITNESS; CARDIOMETABOLIC RISK; AEROBIC EXERCISE;
   PSYCHOSIS; PEOPLE; SCHIZOPHRENIA; INDIVIDUALS
AB Adolescence is among the most vulnerable period for the emergence of serious mental illnesses. Addressing this vulnerability has generated interest in identifying markers of risk for symptoms and opportunities for early intervention. Physical fitness has been linked to psychopathology and may be a useful risk marker and target for early intervention. New wearable technology has made assessing fitness behavior more practical while avoiding recall and self-report bias. Still, questions remain regarding the clinical utility of physical fitness metrics for mental health, both transdiagnostically and along specific symptom dimensions. The current study includes 5007 adolescents (ages 10-13) who participated in the Adolescent Brain Cognitive Development (ABCD) study and additional sub-study that collected fitness data from wearable technology and clinical symptom measures. Physical fitness metrics included resting heart rate (RHR- an index of cardiovascular health), time spent sedentary (associated with increased inflammation and cardiovascular disease), and time spent in moderate physical activity (associated with increased neurogenesis, neuroplasticity, and healthy neurodevelopment). Self-report clinical symptoms included measures of psychosis-like experiences (PLE), internalizing symptoms, and externalizing symptoms. Increased RHR- lower cardiovascular fitness- related only to greater internalizing symptoms (t = 3.63). More sedentary behavior related to elevated PLE severity (t = 5.49). More moderate activity related to lower PLE (t = -2.69) and internalizing (t = -6.29) symptom severity. Wearable technology fitness metrics linked physical health to specific mental health dimensions, which emphasizes the utility of detailed digital health data as a marker for risk and the need for precision in targeting physical health behaviors to benefit symptoms of psychopathology.
C1 [Damme, Katherine S. F.; Mittal, Vijay A.] Northwestern Univ, Dept Psychol, Evanston, IL 60208 USA.
   [Damme, Katherine S. F.; Mittal, Vijay A.] Northwestern Univ, Inst Innovat Dev Sci DevSci, Evanston, IL 60208 USA.
   [Damme, Katherine S. F.; Mittal, Vijay A.] Northwestern Univ, Inst Innovat Dev Sci DevSci, Chicago, IL 60611 USA.
   [Vargas, Teresa G.; Shankman, Stewart A.] Harvard Univ, Dept Psychol, Cambridge, MA USA.
   [Walther, Sebastian] Univ Bern, Univ Hosp Psychiat, Translat Res Ctr, Bern, Switzerland.
   [Mittal, Vijay A.] Northwestern Univ, Dept Psychiat, Chicago, IL USA.
   [Mittal, Vijay A.] Northwestern Univ, Med Social Sci, Chicago, IL USA.
   [Mittal, Vijay A.] Northwestern Univ, Inst Policy Res IPR, Chicago, IL USA.
C3 Northwestern University; Northwestern University; Northwestern
   University; Harvard University; University of Bern; University Hospital
   of Bern; Northwestern University; Northwestern University; Northwestern
   University
RP Damme, KSF (corresponding author), Northwestern Univ, Dept Psychol, Evanston, IL 60208 USA.; Damme, KSF (corresponding author), Northwestern Univ, Inst Innovat Dev Sci DevSci, Evanston, IL 60208 USA.; Damme, KSF (corresponding author), Northwestern Univ, Inst Innovat Dev Sci DevSci, Chicago, IL 60611 USA.
EM Kate.Damme@u.northwestern.edu
RI Mittal, Vijay/JYQ-1035-2024; Walther, Sebastian/E-3486-2010
OI Walther, Sebastian/0000-0003-4026-3561; MITTAL,
   VIJAY/0000-0001-9017-5119; Damme, Katherine/0000-0003-4260-1528
FU U.S. Department of Health & Human Services | NIH | National Institute of
   Mental Health (NIMH) [R01MH103231, R01MH112545, R01MH094650,
   R21/R33MH103231, T32MH126368]; National Institutes of Mental Health
FX This work was supported by the National Institutes of Mental Health
   (Grant R01MH103231, R01MH112545, R01MH094650, R21/R33MH103231;
   T32MH126368).
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NR 65
TC 3
Z9 3
U1 0
U2 7
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 2158-3188
J9 TRANSL PSYCHIAT
JI Transl. Psychiatr.
PD FEB 3
PY 2024
VL 14
IS 1
AR 75
DI 10.1038/s41398-024-02794-2
PG 8
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychiatry
GA GV4N9
UT WOS:001155436400001
PM 38307840
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Karmali, R
   Dalovisio, A
   Borgia, JA
   Venugopal, P
   Kim, BW
   Grant-Szymanski, K
   Hari, P
   Lazarus, H
AF Karmali, Reem
   Dalovisio, Andrew
   Borgia, Jeffrey A.
   Venugopal, Parameswaran
   Kim, Brian W.
   Grant-Szymanski, Kelly
   Hari, Parameswaran
   Lazarus, Hillard
TI All in the family: Clueing into the link between metabolic syndrome and
   hematologic malignancies
SO BLOOD REVIEWS
LA English
DT Review
DE Metabolic syndrome; Hematologic malignancy; Obesity; Dyslipidemia; Lipid
   signaling; Reactive oxygen species; Adipokines; Inflammation; Insulin
   resistance; Insulin signaling; IGF-1; Metformin
ID GROWTH-FACTOR-I; STEM-CELL TRANSPLANTATION; RECEPTOR TYROSINE KINASE;
   NON-HODGKINS-LYMPHOMA; BODY-MASS INDEX; CANCER-RISK; INTERLEUKIN-6
   RECEPTOR; DIABETES-MELLITUS; MYELOID-LEUKEMIA; OXIDATIVE STRESS
AB Metabolic syndrome constitutes a constellation of findings including central obesity, insulin resistance/type 2 diabetes mellitus (DM), dyslipidemia and hypertension. Metabolic syndrome affects 1 in 4 adults in the United States and is rapidly rising in prevalence, largely driven by the dramatic rise in obesity and insulin resistance/DM. Being central to the development of metabolic syndrome and its other related diseases, much focus has been placed on identifying the mitogenic effects of obesity and insulin resistance/DM as mechanistic clues of the link between metabolic syndrome and cancer. Pertinent mechanisms identified include altered lipid signaling, adipokine and inflammatory cytokine effects, and activation of PI3K/Akt/mTOR and RAS/RAF/MAPK/ERK pathways via dysregulated insulin/insulin-like growth factor-1 (IGF-1) signaling. Through variable activation of these multiple pathways, obesity and insulin resistance/DM pre-dispose to hematologic malignancies, imposing the aggressive and chemo-resistant phenotypes typically seen in cancer patients with underlying metabolic syndrome. Growing understanding of these pathways has identified druggable cancer targets, rationalizing the development and testing of agents like PI3K inhibitor idelalisib, mTOR inhibitors everolimus and temsirolimus, and IGF-1 receptor inhibitor linsitinib. It has also led to exploration of obesity and diabetes-directed therapies including statins and oral hypoglycemic for the management of metabolic syndrome-related hematologic neoplasms. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Karmali, Reem; Dalovisio, Andrew; Venugopal, Parameswaran; Grant-Szymanski, Kelly] Rush Univ, Med Ctr, Div Hematol Oncol & Cell Therapy, Chicago, IL 60612 USA.
   [Borgia, Jeffrey A.] Rush Univ, Med Ctr, Rush Prote & Biomarker Dev Core, Dept Pathol, Chicago, IL 60612 USA.
   [Borgia, Jeffrey A.] Rush Univ, Med Ctr, Rush Prote & Biomarker Dev Core, Dept Biochem, Chicago, IL 60612 USA.
   [Kim, Brian W.] Rush Univ, Med Ctr, Div Endocrinol, Chicago, IL 60612 USA.
   [Hari, Parameswaran] Med Coll Wisconsin, Ctr Clin Canc, Milwaukee, WI 53226 USA.
   [Lazarus, Hillard] Case Western Reserve Univ, Novel Cell Therapy, Cleveland, OH 44106 USA.
C3 Rush University; Rush University; Rush University; Rush University;
   Medical College of Wisconsin; University System of Ohio; Case Western
   Reserve University
RP Karmali, R (corresponding author), Rush Univ, Med Ctr, Div Hematol Oncol & Cell Therapy, 1725 Harrison St,Suite 809, Chicago, IL 60612 USA.
EM reem_karmali@rush.edu; Andrew_dalovisio@rush.edu;
   Jeffrey_A_borgia@rush.edu; Parameswaran_Venugopal@rush.edu;
   brian_w_kim@rush.edu; kelly_grant@rush.edu; phari@mcw.edu;
   hillard.lazarus@case.edu
RI Hari, Parameswaran/A-7271-2009; Kim, Brian/GZK-6649-2022
OI Karmali, Reem/0000-0003-0984-4376; Venugopal,
   Parameswaran/0000-0002-7518-9579; Hari, Parameswaran/0000-0002-8800-297X
FU Leukemia Pilot Project Grant from the Rush University Cancer Center;
   Samuel G. Taylor III Chair
FX The data presented in this article was funded in part by the Leukemia
   Pilot Project Grant from the Rush University Cancer Center. Funds were
   also graciously provided by the Samuel G. Taylor III Chair.
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NR 102
TC 16
Z9 17
U1 1
U2 18
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0268-960X
EI 1532-1681
J9 BLOOD REV
JI Blood Rev.
PD MAR
PY 2015
VL 29
IS 2
BP 71
EP 80
DI 10.1016/j.blre.2014.09.010
PG 10
WC Hematology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Hematology
GA CF6OB
UT WOS:000352674900002
PM 25433571
DA 2025-06-11
ER

PT J
AU Sluijs, I
   Beulens, JWJ
   Grobbee, DE
   van der Schouw, YT
AF Sluijs, Ivonne
   Beulens, Joline W. J.
   Grobbee, Diederick E.
   van der Schouw, Yvonne T.
TI Dietary Carotenoid Intake Is Associated with Lower Prevalence of
   Metabolic Syndrome in Middle-Aged and Elderly Men
SO JOURNAL OF NUTRITION
LA English
DT Article
ID FOOD-FREQUENCY QUESTIONNAIRE; 3RD NATIONAL-HEALTH; DIABETES-MELLITUS;
   SERUM CAROTENOIDS; OXIDATIVE STRESS; RISK; SUPPLEMENTATION; VALIDITY;
   REPRODUCIBILITY; CONSUMPTION
AB Carotenoids have antioxidant properties. Little is known about the relation of dietary carotenoid intake on metabolic syndrome risk. We examined whether dietary carotenoid intake was associated with metabolic syndrome and metabolic syndrome risk factors. We conducted a population-based, cross-sectional study in 374 men aged 40-80 y. Intakes of beta-carotene, alpha-carotene, beta-cryptoxanthin, lycopene, lutein, and zeaxanthin were estimated using a validated FFQ. Presence of metabolic syndrome was determined using fasting serum glucose, triglyceride, and HDL-cholesterol concentrations, waist circumference, and systolic and diastolic blood pressure. Metabolic syndrome was present in 22% of the men. After adjustment for confounders, total carotenoid and lycopene intakes were inversely associated with presence of metabolic syndrome [relative risk (RR) quartile 4 vs. quartile 1 (95% Cl) 0,42 (0.20-0.87), P-trend 0.02; and 0.55 (0.28-1.11), P-trend 0.01, respectively]. For beta-carotene, a decreased risk was observed for each quartile of intake compared with the first [RR quartile 4 vs. quartile 1 (95% Cl) 0.58 (0.33-1.02)]. Higher total carotenoid, beta-carotene, alpha-carotene, and lycopene intakes were associated with lower waist circumferences and visceral and subcutaneous fat mass. Higher lycopene intake was related to lower serum triglyceride concentrations. In conclusion, higher total carotenoid intakes, mainly those of beta-carotene and lycopene, were associated with a lower prevalence of metabolic syndrome and with lower measures of adiposity and serum triglyceride concentrations in middle-aged and elderly men. J. Nutr. 139: 987-992, 2009.
C1 [Sluijs, Ivonne; Beulens, Joline W. J.; Grobbee, Diederick E.; van der Schouw, Yvonne T.] Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, NL-3508 GA Utrecht, Netherlands.
C3 Utrecht University; Utrecht University Medical Center
RP Sluijs, I (corresponding author), Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, NL-3508 GA Utrecht, Netherlands.
EM i.sluijs-2@umcutrecht.nl
RI Grobbee, Diederick/C-7651-2014; van der Schouw, Yvonne/F-8327-2014
OI van der Schouw, Yvonne/0000-0002-4605-435X; Beulens,
   Joline/0000-0002-4181-0937
CR [Anonymous], DUTCH FOOD COMP TABL
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NR 36
TC 98
Z9 107
U1 0
U2 13
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0022-3166
EI 1541-6100
J9 J NUTR
JI J. Nutr.
PD MAY
PY 2009
VL 139
IS 5
BP 987
EP 992
DI 10.3945/jn.108.101451
PG 6
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 436OU
UT WOS:000265424500026
PM 19321578
OA Bronze
DA 2025-06-11
ER

PT J
AU Lin, CE
   Chung, CH
   Chen, LF
   You, CH
   Chien, WC
   Chou, PH
AF Lin, Ching-En
   Chung, Chi-Hsiang
   Chen, Li-Fen
   You, Ching-Hui
   Chien, Wu-Chien
   Chou, Po-Han
TI Risk of incident hypertension, diabetes, and dyslipidemia after first
   posttraumatic stress disorder diagnosis: A nationwide cohort study in
   Taiwan
SO GENERAL HOSPITAL PSYCHIATRY
LA English
DT Article
ID MAJOR DEPRESSIVE DISORDER; 2 YEARS PREVENT; METABOLIC SYNDROME;
   RECURRENT EPISODES; INSULIN-RESISTANCE; WEIGHT; ANTIDEPRESSANTS;
   PREVALENCE; VETERANS; DISEASE
C1 [Lin, Ching-En] Taipei Tzu Chi Hosp, Buddhist Tzu Chi Med Fdn, Dept Psychiat, New Taipei, Taiwan.
   [Lin, Ching-En] Tzu Chi Univ, Sch Med, Hualien, Taiwan.
   [Lin, Ching-En; Chien, Wu-Chien] Natl Def Med Ctr, Grad Inst Life Sci, Taipei, Taiwan.
   [Chung, Chi-Hsiang; Chien, Wu-Chien] Natl Def Med Ctr, Tri Serv Gen Hosp, Dept Med Res, Taipei, Taiwan.
   [Chung, Chi-Hsiang; Chien, Wu-Chien] Taiwanese Injury Prevent & Safety Promot Assoc, Taipei, Taiwan.
   [Chung, Chi-Hsiang; Chien, Wu-Chien] Natl Def Med Ctr, Sch Publ Hlth, Taipei, Taiwan.
   [Chen, Li-Fen] Hualien Armed Forces Gen Hosp, Dept Psychiat, Hualien, Taiwan.
   [Chen, Li-Fen] Natl Def Med Ctr, Sch Med, Taipei, Taiwan.
   [You, Ching-Hui] Taipei Med Univ, Taipei Municipal Wanfang Hosp, Dept Family Med, Taipei, Taiwan.
   [Chou, Po-Han] China Med Univ, Hsinchu Hosp, Dept Psychiat, Taichung, Taiwan.
   [Chou, Po-Han] China Med Univ, China Med Univ Hosp, Dept Psychiat, 2 Yude Rd, Taichung 40447, Taiwan.
   [Chou, Po-Han] Natl Chiao Tung Univ, Dept Biol Sci & Technol, Hsinchu, Taiwan.
   [Chou, Po-Han] Natl Chiao Tung Univ, Coll Elect & Comp Engn, Dept Photon, Biol Optimal Imaging Lab, Hsinchu, Taiwan.
C3 Buddhist Tzu Chi General Hospital; Taipei Tzu Chi Hospital; Tzu Chi
   University; National Defense Medical Center; Tri-Service General
   Hospital; National Defense Medical Center; National Defense Medical
   Center; National Defense Medical Center; Taipei Medical University;
   Taipei Municipal WanFang Hospital; China Medical University Taiwan;
   China Medical University Taiwan; China Medical University Hospital -
   Taiwan; National Yang Ming Chiao Tung University; National Yang Ming
   Chiao Tung University
RP Chou, PH (corresponding author), China Med Univ, China Med Univ Hosp, Dept Psychiat, 2 Yude Rd, Taichung 40447, Taiwan.; Chien, WC (corresponding author), Tri Serv Gen Hosp, Dept Med Res, 325,Sect 2,Chenggong Rd, Taipei 11490, Taiwan.
EM chienwu@mail.ndmctsgh.edu.tw; phchou1980@gmail.com
RI Chung, Chi-Hsiang/AAY-3386-2021; Lin, Ching-En/CAA-0084-2022
OI You, Chinghui/0000-0003-2269-4149
FU Tri-Service General Hospital Research Foundation [TSGH-C107-004]
FX This study was supported in part by Tri-Service General Hospital
   Research Foundation (TSGH-C107-004). These funding agencies did not
   influence the study design, data collection and analysis, decision to
   publish, or preparation of the manuscript. We would also like to thank
   Dr. David Wypij and Professor Karestan Koenen at Harvard T.H. Chan
   School of Public Health for their help with the study design and
   statistical analyses.
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NR 75
TC 10
Z9 10
U1 0
U2 4
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0163-8343
EI 1873-7714
J9 GEN HOSP PSYCHIAT
JI Gen. Hosp. Psych.
PD MAY-JUN
PY 2019
VL 58
BP 59
EP 66
DI 10.1016/j.genhosppsych.2019.03.004
PG 8
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA HW0CG
UT WOS:000466347900010
PM 30925303
DA 2025-06-11
ER

PT J
AU Anestal, C
   Garcia, J
   Brazendale, K
AF Anestal, Chelsea
   Garcia, Jeanette
   Brazendale, Keith
TI Metabolic Syndrome Risk Factors in US College Students: A Pre-post Test
   Pilot Study
SO AMERICAN JOURNAL OF LIFESTYLE MEDICINE
LA English
DT Article; Early Access
DE college students; metabolic syndrome; weight gain; stress
ID WEIGHT-GAIN; YOUNG-ADULTS; PREVALENCE; STRESS
AB Purpose: Concerning rises in obesity and type 2 diabetes in college students warrants the investigation of potential mechanisms. The aim of this study was to (1) assess the association between Metabolic Syndrome (MetS) knowledge, perceived stress, and coping resources with changes in MetS risk factors in college students, and (2) examine differences between first-time on-campus and final-year college students. Methods: A pre-post study design over a 16-week semester examined changes in BMI and blood pressure of 43 undergraduate students (mean age 20.5 yrs. old, 86% female, 77% ethnic/racial minority). The MetS Questionnaire, Perceived Stress Scale, and Coping Resources Inventory were administered at baseline. Mixed-effects linear regression and independent samples t-tests were computed. Results/findings: There were no significant associations between changes in MetS risk factors and MetS knowledge, perceived stress, and coping resources. Students on campus for the first time had higher increases in BMI and gained more weight compared to students in their final years of college (P < .05). Conclusions: Findings from this preliminary study suggest that students attending college for the first time demonstrate poorer MetS risk factors compared to peers. Additional studies are needed to explore the causal mechanism driving poor health outcomes in first time college students.
C1 Univ Cent Florida, Dept Hlth Sci, Orlando, FL USA.
   Univ Cent Florida, Burnett Honors Coll, Orlando, FL USA.
   Univ Cent Florida, Dept Hlth Sci, Orlando, FL USA.
   [Brazendale, Keith] Univ Cent Florida, Coll Hlth Profess & Sci, Dept Hlth Sci, 4364 Scorpius St, Orlando, FL 32816 USA.
C3 State University System of Florida; University of Central Florida; State
   University System of Florida; University of Central Florida; State
   University System of Florida; University of Central Florida; State
   University System of Florida; University of Central Florida
RP Brazendale, K (corresponding author), Univ Cent Florida, Coll Hlth Profess & Sci, Dept Hlth Sci, 4364 Scorpius St, Orlando, FL 32816 USA.
EM Keith.brazendale@ucf.edu
RI Garcia, Jeanette/MTB-3664-2025; Brazendale, Keith/ABB-1965-2021
OI Brazendale, Keith/0000-0001-9233-1621
FU Burnett Honors College; Office of Honors Research; Office of
   Undergraduate Research at the University of Central Florida
FX The authors would like to thank the Department of Health Sciences at the
   University of Central Florida for providing the equipment and financial
   assistance for participant incentives. The authors would also like to
   thank the following research assistants, Arielle Lopez, Zoe Eisner,
   Carina McClean, Keri Allen, and Alex Osborne. Finally, the authors would
   like to acknowledge the Burnett Honors College, the Office of Honors
   Research, and the Office of Undergraduate Research at the University of
   Central Florida for professional development resources in support of the
   research.
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NR 26
TC 0
Z9 0
U1 0
U2 4
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1559-8276
EI 1559-8284
J9 AM J LIFESTYLE MED
JI Am. J. Lifestyle Med.
PD 2023 JAN 15
PY 2023
DI 10.1177/15598276231151922
EA JAN 2023
PG 8
WC Public, Environmental & Occupational Health
WE Emerging Sources Citation Index (ESCI)
SC Public, Environmental & Occupational Health
GA 7X5DM
UT WOS:000914219600001
DA 2025-06-11
ER

PT J
AU Wong, ND
   Rozanski, A
   Gransar, H
   Miranda-Peats, R
   Kang, XP
   Hayes, S
   Shaw, L
   Friedman, J
   Polk, D
   Berman, DS
AF Wong, ND
   Rozanski, A
   Gransar, H
   Miranda-Peats, R
   Kang, XP
   Hayes, S
   Shaw, L
   Friedman, J
   Polk, D
   Berman, DS
TI Metabolic syndrome and diabetes are associated with an increased
   likelihood of inducible myocardial ischemia among patients with
   subclinical atherosclerosis
SO DIABETES CARE
LA English
DT Article
ID CORONARY-ARTERY CALCIUM; EMISSION COMPUTED-TOMOGRAPHY; PROGNOSTIC VALUE;
   HEART-DISEASE; US ADULTS; PREVALENCE; RISK; PREDICTION; MORTALITY;
   EVENTS
AB OBJECTIVE - Coronary artery calcification (CAC) is associated with cardiac events and the likelihood of inducible myocardial ischemia. Because metabolic syndrome contributes to atherosclerosis, we assessed whether it also influences the relationship between CAC levels and myocardial ischemia.
   RESEARCH DESIGN AND METHODS - We evaluated 1,043 patients without known coronary artery disease (CAD) who underwent stress myocardial perfusion scintigraphy (MPS) and computed tomography. Metabolic syndrome was defined by modified National Cholesterol Education Program criteria. Metabolic abnormalities were present in 313 patients (30%), including 140 with diabetes (with or without metabolic syndrome) and 173 who had metabolic syndrome without diabetes.
   RESULTS - Although CAC scores < 100 identified a low likelihood (similar to 2%) of ischemia, the presence (versus absence) of metabolic abnormalities (metabolic syndrome or diabetes) was a predictor of more frequent ischemia among patients with CAC scores of 100-399 (13.0 vs. 3.6%, P < 0.02) and CAC scores >= 400 (23.4 vs. 13.6%, P = 0.03). Similar trends were observed when patients with metabolic syndrome and diabetes were considered separately. Multiple logistic regression revealed the odds of MPS ischemia to be 4.3-fold greater per SD of log CAC (P < 0.001) and 2.0-fold greater in the presence of metabolic abnormalities (P < 0.01).
   CONCLUSIONS- Among patients with CAC scores >= 100, metabolic abnormalities, and even metabolic syndrome in the absence of diabetes predicted a higher likelihood of inducible. ischemia. These findings suggest the need for assessment of metabolic status when interpreting the results of CAC imaging among patients undergoing such testing because of suspected CAD.
C1 Cedars Sinai Med Ctr, Dept Imaging, Los Angeles, CA 90048 USA.
   Univ Calif Irvine, Div Cardiol, Heart Dis Prevent Program, Irvine, CA USA.
   St Lukes Roosevelt Hosp, Dept Cardiol, New York, NY USA.
C3 Cedars Sinai Medical Center; University of California System; University
   of California Irvine; Mount Sinai West; Mount Sinai St. Luke's
RP Cedars Sinai Med Ctr, Dept Imaging, 8700 Beverly Bldg,Room 1258, Los Angeles, CA 90048 USA.
EM bermand@cshs.org
RI berman, daniel/ABF-0670-2022
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NR 27
TC 80
Z9 81
U1 0
U2 1
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0149-5992
EI 1935-5548
J9 DIABETES CARE
JI Diabetes Care
PD JUN
PY 2005
VL 28
IS 6
BP 1445
EP 1450
DI 10.2337/diacare.28.6.1445
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 931QM
UT WOS:000229500000028
PM 15920066
OA Bronze
DA 2025-06-11
ER

PT J
AU Davis, J
   Fujimoto, RY
   Juarez, DT
   Hodges, KA
   Asam, JK
AF Davis, James
   Fujimoto, Ronald Y.
   Juarez, Deborah Taira
   Hodges, Krista A.
   Asam, J. Kuhio
TI Major depression associated with rates of cardiovascular disease state
   transitions
SO AMERICAN JOURNAL OF MANAGED CARE
LA English
DT Article
ID CORONARY-HEART-DISEASE; METABOLIC SYNDROME; RISK-FACTOR; FOLLOW-UP;
   STRESS; PREVALENCE; MORTALITY; SYMPTOMS; PATHOGENESIS; HYPERTENSION
AB Objective:To compare patients with and without major depression with respect to their rates of transition to several stages of cardiovascular disease progression.
   Study Design: Retrospective observational study.
   Methods:The study used administrative data from a large insurer in Hawaii to evaluate associations of major depression with cardiovascular progression. Analyses used competing-risks models, models that allow more than 1 type of possible outcome event at the transition stages. All analyses were adjusted for age and sex.
   Results: Among nearly 600,000 healthy members, those with major depression in the past year were 50% to 100% more likely than controls to develop hypertension or dyslipidemia. Rates were increased to a similar magnitude (1) among patients with hypertension or dyslipidemia who subsequently developed either the other condition or coronary artery disease and (2) among patients with hypertension and dyslipiclemia who developed coronary artery disease or congestive heart failure. Transition rates to coronary artery disease or congestive heart failure also were increased 50% to 100% among patients with diabetes, hypertension, and dyslipidemia. The sequence of associations remained as strong examining depression 1-2 years in the past as with depression in the past year.
   Conclusions: The results show a pattern of faster transitions for patients with major depression compared with patients without major depression across both the early and later stages of cardiovascular progression. Health plans offer a setting where patients with depression can be identified and where interventions might be undertaken to minimize the possible effects of depression on transition rates.
C1 [Davis, James; Fujimoto, Ronald Y.; Juarez, Deborah Taira; Hodges, Krista A.] Hawaii Med Serv Assoc, Honolulu, HI 96813 USA.
   [Asam, J. Kuhio] APS Healthcare, Honolulu, HI USA.
   [Davis, James; Juarez, Deborah Taira; Asam, J. Kuhio] Univ Hawaii, Honolulu, HI 96822 USA.
C3 University of Hawaii System
RP Davis, J (corresponding author), Hawaii Med Serv Assoc, 818 Keeaumoku St, Honolulu, HI 96813 USA.
EM james_davis@hmsa.com
OI Taira, Deborah/0000-0002-1989-0109
CR [Anonymous], HEDIS 2007 TECHN SPE
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NR 34
TC 14
Z9 17
U1 0
U2 1
PU MANAGED CARE & HEALTHCARE COMMUNICATIONS LLC
PI PLAINSBORO
PA 666 PLAINSBORO RD, STE 300, PLAINSBORO, NJ 08536 USA
SN 1088-0224
J9 AM J MANAG CARE
JI Am. J. Manag. Care
PD MAR
PY 2008
VL 14
IS 3
BP 125
EP 129
PG 5
WC Health Care Sciences & Services; Health Policy & Services; Medicine,
   General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services; General & Internal Medicine
GA 273KJ
UT WOS:000253928700001
PM 18333704
DA 2025-06-11
ER

PT J
AU Student, J
   Sowers, J
   Lockette, W
AF Student, Jeffrey
   Sowers, James
   Lockette, Warren
TI THIRSTY FOR FRUCTOSE: Arginine Vasopressin, Fructose, and the
   Pathogenesis of Metabolic and Renal Disease
SO FRONTIERS IN CARDIOVASCULAR MEDICINE
LA English
DT Review
DE fructose; vasopressin (ADH); Mesoamerican nephropathy; metabolic
   syndrome; high fructose corn syrup (HFCS)
ID PITUITARY-ADRENAL AXIS; CHROMOSOMAL LOCALIZATION; INSULIN-RESISTANCE;
   PLASMA COPEPTIN; US ADULTS; STRESS; RECEPTOR; FRUCTOKINASE; OBESITY;
   PREVALENCE
AB We review the pathways by which arginine vasopressin (AVP) and hydration influence the sequelae of the metabolic syndrome induced by high fructose consumption. AVP and inadequate hydration have been shown to worsen the severity of two phenotypes associated with metabolic syndrome induced by high fructose intake-enhanced lipogenesis and insulin resistance. These findings have implications for those who frequently consume sweeteners such as high fructose corn syrup (HFCS). Patients with metabolic syndrome are at higher risk for microalbuminuria and/or chronic kidney disease; however, it is difficult to discriminate the detrimental renal effects of the metabolic syndrome from those of hypertension, impaired glucose metabolism, and obesity. It is not surprising the prevalence of chronic renal insufficiency is growing hand in hand with obesity, insulin resistance, and metabolic syndrome in those who consume large amounts of fructose. Higher AVP levels and low hydration status worsen the renal insufficiency found in patients with metabolic syndrome. This inter-relationship has public health consequences, especially among underserved populations who perform physical labor in environments that place them at risk for dehydration. MesoAmerican endemic nephropathy is a type of chronic kidney disease highly prevalent in hot ambient climates from southwest Mexico through Latin America. There is growing evidence that this public health crisis is being spurred by greater fructose consumption in the face of dehydration and increased dehydration-dependent vasopressin secretion. Work is needed at unraveling the mechanism(s) by which fructose consumption and increased AVP levels can worsen the renal disease associated with components of the metabolic syndrome.
C1 [Student, Jeffrey] Drexel Univ, Coll Med, Philadelphia, PA 19104 USA.
   [Sowers, James] Univ Missouri, Div Endocrinol, Sch Med, Columbia, MO USA.
   [Lockette, Warren] Wayne State Univ, Div Endocrinol, Sch Med, Detroit, MI USA.
C3 Drexel University; University of Missouri System; University of Missouri
   Columbia; Wayne State University
RP Student, J (corresponding author), Drexel Univ, Coll Med, Philadelphia, PA 19104 USA.
EM jts374@drexel.edu
FU Department of Defense and Henry M. Jackson Foundation for the
   Advancement of Military Medicine [HU0001-18-2-0016]; HJF Award
   [309833-1.00-65546]
FX This work was supported, in part, by the Department of Defense and Henry
   M. Jackson Foundation for the Advancement of Military Medicine,
   HU0001-18-2-0016, HJF Award, 309833-1.00-65546.
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NR 72
TC 9
Z9 10
U1 0
U2 10
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2297-055X
J9 FRONT CARDIOVASC MED
JI Front. Cardiovasc. Med.
PD MAY 17
PY 2022
VL 9
AR 883365
DI 10.3389/fcvm.2022.883365
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 1T8LT
UT WOS:000804978100001
PM 35656391
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Jia, GH
   Aroor, AR
   Whaley-Connell, AT
   Sowers, JR
AF Jia, Guanghong
   Aroor, Annayya R.
   Whaley-Connell, Adam T.
   Sowers, James R.
TI Fructose and Uric Acid: Is There a Role in Endothelial Function?
SO CURRENT HYPERTENSION REPORTS
LA English
DT Article
DE Cardiorenal metabolic syndrome; Nitric oxide; Lipogenesis; Insulin
   resistance; Hypertension; Oxidative stress; Inflammation; Estrogen
ID CARDIORENAL METABOLIC SYNDROME; ESTROGEN-RECEPTOR-ALPHA; NITRIC-OXIDE
   SYNTHASE; INSULIN-RESISTANCE; DIETARY FRUCTOSE; OBESITY; DYSFUNCTION;
   RATS; ACTIVATION; EXPRESSION
AB Population level data support that consumption of fructose and fructose-based sweeteners has dramatically increased and suggest that high dietary intake of fructose is an important factor in the development of the cardiorenal metabolic syndrome (CRS). The CRS is a constellation of cardiac, kidney and metabolic disorders including insulin resistance, obesity, metabolic dyslipidemia, high blood pressure, and evidence of early cardiac and kidney disease. The consequences of fructose metabolism may result in intracellular ATP depletion, increased uric acid production, oxidative stress, inflammation, and increased lipogenesis, which are associated with endothelial dysfunction. Endothelial dysfunction is an early manifestation of vascular disease and a driver for the development of CRS. A better understanding of fructose overconsumption in the development of CRS may provide new insights into pathogenesis and future therapeutic strategies.
C1 [Jia, Guanghong; Aroor, Annayya R.; Whaley-Connell, Adam T.; Sowers, James R.] Univ Missouri, Sch Med, Dept Med, Div Endocrinol & Metab, Columbia, MO 65212 USA.
   [Whaley-Connell, Adam T.] Univ Missouri, Sch Med, Dept Med, Div Nephrol & Hypertens, Columbia, MO 65212 USA.
   [Jia, Guanghong; Aroor, Annayya R.; Whaley-Connell, Adam T.; Sowers, James R.] Harry S Truman Mem Vet Hosp, Res Serv, Columbia, MO 65201 USA.
   [Sowers, James R.] Univ Missouri, Sch Med, Dept Med Pharmacol & Physiol, Columbia, MO 65212 USA.
   [Jia, Guanghong; Aroor, Annayya R.; Whaley-Connell, Adam T.; Sowers, James R.] Univ Missouri, Sch Med, Diabet & Cardiovasc Ctr, Columbia, MO 65212 USA.
C3 University of Missouri System; University of Missouri Columbia;
   University of Missouri System; University of Missouri Columbia; US
   Department of Veterans Affairs; Veterans Health Administration (VHA);
   Harry S. Truman Memorial Veterans' Hospital; University of Missouri
   System; University of Missouri Columbia; University of Missouri System;
   University of Missouri Columbia
RP Sowers, JR (corresponding author), Univ Missouri, Sch Med, Dept Med Pharmacol & Physiol, MA415 Med Sci Bldg,One Hosp Dr, Columbia, MO 65212 USA.
EM sowersj@health.missouri.edu
OI Whaley-Connell, Adam/0000-0001-8955-5560
FU National Institutes of Health [HL-73101, HL-107910, AG-040638]; Veterans
   Affairs Merit System [0018, CDA-2]
FX The authors would like to thank Brenda Hunter for her editorial
   assistance. This research was supported by National Institutes of Health
   grants HL-73101 and HL-107910 to J.R.S. and AG-040638 to A. W.-C. and
   the Veterans Affairs Merit System 0018 (J.R.S.) and CDA-2 (A.W.-C.).
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NR 56
TC 50
Z9 58
U1 0
U2 16
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1522-6417
EI 1534-3111
J9 CURR HYPERTENS REP
JI Curr. Hypertens. Rep.
PD JUN
PY 2014
VL 16
IS 6
AR 434
DI 10.1007/s11906-014-0434-z
PG 7
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA AI5LX
UT WOS:000336909700004
PM 24760443
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Neumann, E
   Rössler, S
   Vetter, S
   Seifritz, E
   Hotzy, F
   Mötteli, S
AF Neumann, Eileen
   Rossler, Simone
   Vetter, Steffan
   Seifritz, Erich
   Hotzy, Florian
   Motteli, Sonja
TI Dietary challenges and desired support strategies in patients with
   severe mental illness: insights from a qualitative focus group study
SO NUTRITIONAL NEUROSCIENCE
LA English
DT Article; Early Access
DE Severe mental illness; nutrition; qualitative research; focus groups;
   depression; schizophrenia; interventions; barriers
ID LEARNED HELPLESSNESS; METABOLIC SYNDROME; WEIGHT; PEOPLE; SCHIZOPHRENIA;
   INTERVENTIONS; PSYCHIATRY; DISORDERS; MORTALITY; RISK
AB Objectives:Patients with severe mental illnesses (SMI), such as schizophrenia and depression, face significant challenges in maintaining healthy dietary habits. However, in practice, easily accessible and available options for nutritional support in psychiatric settings remain lacking. This study aimed to identify the specific difficulties faced by these patients and explore the types of support they find most beneficial.Methods:Using a qualitative, participatory approach we conducted six focus groups with 4-9 patients from the Psychiatric University Hospital Zurich between September and December 2023. The interviews were guided by a pre-developed discussion guideline and analyzed using MAXQDA with qualitative content analysis based on Graneheim and Lundman's approach. A deductive-inductive method was chosen for coding the transcripts.Results:A total of 38 patients (50% female, 23-61 years, 92% with depression, 5% with schizophrenia, 3% did not state the diagnosis) described a range of difficulties related to meal preparation and cooking, emotional eating, and medical factors, all compounded by overarching problems regarding daily structure and feelings of resignation. Participants were open to a variety of support options, with preference for practical hands-on support from mental health professionals to help translate their knowledge into action (e.g. support with shopping or meal planning). Participants wanted to be actively asked about nutrition problems.Discussion:The findings highlight the complex interplay of cognitive, emotional, and practical barriers to healthy eating in patients with SMI. There is a need for integrated nutritional support within psychiatric care, emphasizing the importance of practical, personalized, and proactive interventions.
C1 [Neumann, Eileen; Vetter, Steffan; Seifritz, Erich; Hotzy, Florian] Univ Zurich, Psychiat Univ Hosp Zurich, Dept Psychiat Psychotherapy & Psychosomat, Zurich, Switzerland.
   [Rossler, Simone] Zurich Univ Appl Sci, Clin Psychol & Hlth Psychol, Zurich, Switzerland.
   [Motteli, Sonja] Univ Bern, Univ Hosp Psychiat & Psychotherapy, Bern, Switzerland.
C3 University of Zurich; Zurich University of Applied Sciences; University
   of Bern; University Hospital of Bern
RP Neumann, E (corresponding author), Psychiat Univ Hosp Zurich, Dept Psychiat Psychotherapy & Psychosomat, Militarstr 8,Postfach, CH-8021 Zurich, Switzerland.
EM eileen.neumann@pukzh.ch
CR Afzal M, 2021, FRONT ENDOCRINOL, V12, DOI 10.3389/fendo.2021.769309
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NR 39
TC 0
Z9 0
U1 0
U2 0
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1028-415X
EI 1476-8305
J9 NUTR NEUROSCI
JI Nutr. Neurosci.
PD 2025 MAY 7
PY 2025
DI 10.1080/1028415X.2025.2502026
EA MAY 2025
PG 8
WC Neurosciences; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Nutrition & Dietetics
GA 2IH9N
UT WOS:001483333800001
PM 40332228
DA 2025-06-11
ER

PT J
AU Sheffield-Abdullah, KM
   Woods-Giscombe, CL
AF Sheffield-Abdullah, Karen M.
   Woods-Giscombe, Cheryl L.
TI Perceptions of superwoman schema and stress among African American women
   with pre-diabetes
SO ARCHIVES OF PSYCHIATRIC NURSING
LA English
DT Article
AB Three focus groups were conducted with African American women with elevated cardiometabolic risk to better understand how Superwoman Schema/the strong Black woman role influences their stress and how this cognitive-emotional aspect of health may need to be targeted in future research on cardiometabolic health disparities, such as prediabetes and diabetes. Results from this study revealed that participants' descriptions of stress and the superwoman role were consistent with the Superwoman Schema Conceptual Framework, including specific emphasis on 1) an obligation to manifest strength, 2) an obligation to suppress emotions and 3) an obligation to help others. Implications for targeting Superwoman Schema and stress as social determinants of health are described.
C1 [Sheffield-Abdullah, Karen M.; Woods-Giscombe, Cheryl L.] Univ N Carolina, Chapel Hill, NC 27515 USA.
C3 University of North Carolina; University of North Carolina Chapel Hill
RP Woods-Giscombe, CL (corresponding author), Univ N Carolina, Chapel Hill, NC 27515 USA.
EM cherylw@email.unc.edu
RI GISCOMBE, CHERYL/AAG-5815-2020
OI Sheffield-Abdullah, Karen/0000-0001-5054-2885
FU National Institutes of Health/National Center for Complementary and
   Integrative Health [5T32 AT003378]; National Institutes of
   Health/National Institute of Nursing Research Grant [5T32 NR007091];
   National Institutes of Health/National Center on Complementary and
   Alternative Medicine Grant [1R21AT004276-01A2]; Robert Wood Johnson
   Foundation; Nurse Faculty Scholars Program
FX Dr. Sheffield-Abdullah was supported by the following grants during work
   on this study: National Institutes of Health/National Center for
   Complementary and Integrative Health Grant #5T32 AT003378 (Research in
   Complementary, Alternative and Integrative Medicine), National
   Institutes of Health/National Institute of Nursing Research Grant #5T32
   NR007091 (Interventions for Preventing and Managing Chronic Illness).
   Dr. Woods-Giscombe was supported by the following grants during work on
   this study: National Institutes of Health/National Center on
   Complementary and Alternative Medicine Grant #1R21AT004276-01A2 and
   Robert Wood Johnson Foundation, Nurse Faculty Scholars Program.
CR [Anonymous], OFFICIAL REPORT AM P
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NR 22
TC 11
Z9 21
U1 0
U2 2
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0883-9417
EI 1532-8228
J9 ARCH PSYCHIAT NURS
JI Arch. Psychiatr. Nurs.
PD FEB
PY 2021
VL 35
IS 1
BP 88
EP 93
DI 10.1016/j.apnu.2020.09.011
EA FEB 2021
PG 6
WC Nursing; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Psychiatry
GA QI3MP
UT WOS:000618883500012
PM 33593520
OA Green Accepted, Green Published
DA 2025-06-11
ER

PT J
AU Kaufman, D
   Banerji, MA
   Shorman, I
   Smith, ELP
   Coplan, JD
   Rosenblum, LA
   Kral, JG
AF Kaufman, Daniel
   Banerji, Mary Ann
   Shorman, Igor
   Smith, Eric L. P.
   Coplan, Jeremy D.
   Rosenblum, Leonard A.
   Kral, John G.
TI Early life stress and the development of obesity and insulin resistance
   in juvenile bonnet macaques
SO DIABETES
LA English
DT Article
ID CORTICOTROPIN-RELEASING-FACTOR; CEREBROSPINAL-FLUID CONCENTRATIONS;
   NONHUMAN-PRIMATES; METABOLIC SYNDROME; ADIPOSITY; GLUCOSE; ADIPONECTIN;
   SENSITIVITY; RESPONSES; PATTERNS
AB Stress is a risk factor for chronic illnesses such as obesity, type 2 diabetes, and hypertension and has been postulated to cause the metabolic syndrome via perturbation of the hypothalamo-pituitary-adrenal (HPA) axis. In our model of early-life stress (variable foraging demand [VFD]), food insecurity is imposed on monkey mothers for 16 weeks beginning when their nursing offspring are 3-5 months of age. Under VFD, food availability is never restricted, and the infant's growth is unaffected. VFD rearing does, however, cause a range of neurobiological abnormalities, including dysregulation of the HPA axis, manifested in abnormal cerebrospinal fluid cortisol and corticotropin-releasing factor levels. We previously reported spontaneous occurrence of metabolic syndrome in 14% of normally reared peripubertal bonnet macaques given ad libitum access to standard monkey chow. Here, we show that compared with normally reared monkeys, peripubertal VFD juveniles exhibit greater weight, BMI, abdominal circumference, and glucagon-like peptide-1 and decreased glucose disposal rates during hyperinsulinemic-euglycemic clamps. Our data suggest that early-life stress during a critical period of neuro development can result in the peripubertal emergence of obesity and insulin resistance:
C1 Suny Downstate Med Ctr, Dept Surg, Brooklyn, NY 11203 USA.
   Suny Downstate Med Ctr, Primate Behav Lab, Brooklyn, NY 11203 USA.
   Suny Downstate Med Ctr, Dept Med, Brooklyn, NY 11203 USA.
   Suny Downstate Med Ctr, Dept Psychiat, Brooklyn, NY 11203 USA.
C3 State University of New York (SUNY) System; SUNY Downstate Health
   Sciences University; State University of New York (SUNY) System; SUNY
   Downstate Health Sciences University; State University of New York
   (SUNY) System; SUNY Downstate Health Sciences University; State
   University of New York (SUNY) System; SUNY Downstate Health Sciences
   University
RP Kral, JG (corresponding author), Suny Downstate Med Ctr, Dept Surg, Box 40,450 Clarkson Ave, Brooklyn, NY 11203 USA.
EM jkral@downstate.edu
RI smith, Eric/KGL-0324-2024
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NR 38
TC 111
Z9 129
U1 0
U2 12
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0012-1797
EI 1939-327X
J9 DIABETES
JI Diabetes
PD MAY
PY 2007
VL 56
IS 5
BP 1382
EP 1386
DI 10.2337/db06-1409
PG 5
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 165GG
UT WOS:000246291500023
PM 17470564
OA Bronze
DA 2025-06-11
ER

PT J
AU Mendrick, DL
   Diehl, AM
   Topor, LS
   Dietert, RR
   Will, Y
   La Merrill, MA
   Bouret, S
   Varma, V
   Hastings, KL
   Schug, TT
   Hart, SGE
   Burlesona, FG
AF Mendrick, Donna L.
   Diehl, Anna Mae
   Topor, Lisa S.
   Dietert, Rodney R.
   Will, Yvonne
   La Merrill, Michele A.
   Bouret, Sebastien
   Varma, Vijayalaskshmi
   Hastings, Kenneth L.
   Schug, Thaddeus T.
   Hart, Susan G. Emeigh
   Burlesona, Florence G.
TI Metabolic Syndrome and Associated Diseases: From the Bench to the Clinic
SO TOXICOLOGICAL SCIENCES
LA English
DT Review
DE metabolic syndrome; diabetes; microbiome; cardiovascular disease;
   inflammation; mitochondria
ID BODY-MASS INDEX; ENDOCRINE-DISRUPTING CHEMICALS; MATERNAL WEIGHT-GAIN;
   DIABETES-MELLITUS; GUT MICROBIOTA; RISK-FACTORS; OBESITY; CHILDHOOD;
   EXPOSURE; HEALTH
AB Metabolic Syndrome and Associated Diseases: From the Bench to the Clinic, a Society of Toxicology Contemporary Concepts in Toxicology (CCT) workshop was held on March 11, 2017. The meeting was convened to raise awareness of metabolic syndrome and its associated diseases and serve as a melting pot with scientists of multiple disciplines (eg, toxicologists, clinicians, regulators) so as to spur research and understanding of this condition. The criteria for metabolic syndrome include obesity, dyslipidemia (low high-density lipoprotein and/or elevated triglycerides), elevated blood pressure, and alterations in glucose metabolism. It can lead to a greater potential of type 2 diabetes, lipid disorders, cardiovascular disease, hepatic steatosis, and other circulatory disorders. Although there are no approved drugs specifically for this syndrome, many drugs target diseases associated with this syndrome thus potentially increasing the likelihood of drug-drug interactions. There is currently significant research focusing on understanding the key pathways that control metabolism, which would be likely targets of risk factors (eg, exposure to xenobiotics, genetics) and lifestyle factors (eg, microbiome, nutrition, and exercise) that contribute to metabolic syndrome. Understanding these pathways could also lead to the development of pharmaceutical interventions. As individuals with metabolic syndrome have signs similar to that of toxic responses (eg, oxidative stress and inflammation) and organ dysfunction, these alterations should be taken into account in drug development. With the increasing frequency of metabolic syndrome in the general population, the idea of a "normal" individual may need to be redefined. This paper reports on the substance and outcomes of this workshop.
C1 [Mendrick, Donna L.] US FDA, Regulatory Act, Natl Ctr Toxicol Res, Bldg 32,Room 2208,10903 New Hampshire Ave, Silver Spring, MD 20993 USA.
   [Diehl, Anna Mae] Duke Univ, Dept Med, Sch Med, Div Gastroenterol, Durham, NC 27710 USA.
   [Topor, Lisa S.] Brown Univ, Warren Alpert Med Sch, Providence, RI 02903 USA.
   [Topor, Lisa S.] Rhode Isl Hosp, Pediat Endocrinol, Providence, RI 02903 USA.
   [Dietert, Rodney R.] Cornell Univ, Coll Vet Med, Dept Microbiol & Immunol, Ithaca, NY 14853 USA.
   [Will, Yvonne] Pfizer Inc, Drug Safety Res & Dev, Groton, CT 06340 USA.
   [La Merrill, Michele A.] Univ Calif Davis, Dept Environm Toxicol, Davis, CA 95616 USA.
   [Bouret, Sebastien; Varma, Vijayalaskshmi] Univ Southern Calif, Kerk Sch Med, Los Angeles, CA 90027 USA.
   [Bouret, Sebastien; Varma, Vijayalaskshmi] Jean Pierre Aubert Res Ctr, Jean Pierre Aubert Res Ctr, Lille, France.
   [Bouret, Sebastien; Varma, Vijayalaskshmi] US FDA, Div Syst Biol, Natl Ctr Toxicol Res, Jefferson, AR 72079 USA.
   [Hastings, Kenneth L.] Hastings Toxicol Consulting LLC, Mt Airy, MD 21771 USA.
   [Schug, Thaddeus T.] NIEHS, Div Extramural Res, POB 12233, Res Triangle Pk, NC 27709 USA.
   [Hart, Susan G. Emeigh] Boehringer Ingelheim Pharmaceut Inc, Expt Pathol, 90 E Ridge POB 368, Ridgefield, CT 06877 USA.
   [Burlesona, Florence G.] Burleson Res Technol Inc, Morrisville, NC 27560 USA.
C3 US Food & Drug Administration (FDA); Duke University; Brown University;
   Lifespan Health Rhode Island; Rhode Island Hospital; Cornell University;
   Pfizer; Pfizer USA; University of California System; University of
   California Davis; University of Southern California; Institut National
   de la Sante et de la Recherche Medicale (Inserm); Universite de Lille;
   US Food & Drug Administration (FDA); National Institutes of Health (NIH)
   - USA; NIH National Institute of Environmental Health Sciences (NIEHS);
   Boehringer Ingelheim
RP Mendrick, DL (corresponding author), US FDA, Regulatory Act, Natl Ctr Toxicol Res, Bldg 32,Room 2208,10903 New Hampshire Ave, Silver Spring, MD 20993 USA.
EM donna.mendrick@fda.hhs.gov
RI Bouret, Sebastien/AAG-7120-2021
OI Bouret, Sebastien/0000-0002-4174-9769
FU Society of Toxicology; BRT Burleson Research Technologies, Inc.;
   National Institute of Environmental Health Sciences; American College of
   Toxicology; Charles River; Gilead; Merck; Society of Toxicologic
   Pathology; Scientific Liaison Coalition
FX Sponsors of the meeting included the Society of Toxicology, BRT Burleson
   Research Technologies, Inc., the National Institute of Environmental
   Health Sciences, the American College of Toxicology, Charles River,
   Gilead, Merck, Society of Toxicologic Pathology, and the Scientific
   Liaison Coalition. It was endorsed by the Endocrine Society.
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NR 61
TC 148
Z9 170
U1 0
U2 22
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1096-6080
EI 1096-0929
J9 TOXICOL SCI
JI Toxicol. Sci.
PD MAR
PY 2018
VL 162
IS 1
BP 36
EP 42
DI 10.1093/toxsci/kfx233
PG 7
WC Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Toxicology
GA FY7DD
UT WOS:000427020900006
PM 29106690
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Winarsi, H
   Septiana, AT
AF Winarsi, H.
   Septiana, A. T.
TI Improving oxidative stress and inflammation status of obese women with
   metabolic syndrome using phenolic-rich red kidney bean sprout milk
   yogurt
SO INTERNATIONAL FOOD RESEARCH JOURNAL
LA English
DT Article
DE SOD; TNF-alpha; BMI; phenolic; red kidney bean sprout milk yogurt
ID OLIVE OIL PHENOLS; TEA POLYPHENOLS; MECHANISMS; INHIBITION; EXPRESSION;
   ANTIOXIDANT; FLAVONOIDS; HUMANS; CELLS; ACID
AB Oxidative stress and inflammation are involved in the pathogenesis of metabolic syndrome (MetS). Antioxidant-rich food products are known for improving the oxidative stress and inflammation as well as inhibiting the development of metabolic syndrome. The present work thus aimed to determine the effects of phenolic-rich red kidney bean sprout milk yogurt (RKBSMY) on superoxide dismutase (SOD) activity, TNF-alpha level, and body mass index (BMI) of women with MetS. Thirty obese women with MetS, low SOD activity, and high TNF-alpha level served as research subjects. The 2-month intervention using red kidney bean sprout milk yogurt (RKBSMY) with 2% lactic acid bacterial starter, 10% sucrose, and 24-h fermentation was conducted to women with MetS. Results showed that RKBSMY increased the SOD activity from 5.13 to 8.02 ng/mL (p = 0.047), decreased the plasma TNF-alpha level from 60.89 to 39.77 pg/mL (p < 0.05), and decreased the BMI from 28.04 to 24.38 kg/m(2). Therefore RKBSMY could be beneficial for people with degenerative diseases associated with oxidative stress. (c) All Rights Reserved
C1 [Winarsi, H.] Univ Jenderal Soedirman, Fac Hlth Sci, Dept Nutr Sci, Purwokerto 53123, Central Java, Indonesia.
   [Septiana, A. T.] Univ Jenderal Soedirman, Fac Agr, Dept Food Technol, Purwokerto 53123, Central Java, Indonesia.
C3 Universitas Jenderal Soedirman; Universitas Jenderal Soedirman
RP Winarsi, H (corresponding author), Univ Jenderal Soedirman, Fac Hlth Sci, Dept Nutr Sci, Purwokerto 53123, Central Java, Indonesia.
EM winarsi12@gmail.com
RI Septiana, Aisyah/AAE-8657-2021; Winarsi, Hery/AAD-5536-2021
FU Directorate General of Development and Research Enhancement of the
   Ministry of Research, Technology, and Higher Education of Indonesia
   [P/1782/UN23/14PN/2019]
FX The present work was financially supported by the Directorate General of
   Development and Research Enhancement of the Ministry of Research,
   Technology, and Higher Education of Indonesia through the
   Competency-based Research Scheme (grant no.: P/1782/UN23/14PN/2019 on
   May 2, 2019).
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NR 39
TC 0
Z9 0
U1 3
U2 16
PU UNIV PUTRA MALAYSIA PRESS
PI SELANGOR
PA SERDANG, SELANGOR, 00000, MALAYSIA
SN 1985-4668
EI 2231-7546
J9 INT FOOD RES J
JI Int. Food Res. J.
PD FEB
PY 2022
VL 29
IS 1
BP 142
EP 148
DI 10.47836/ifrj.29.1.16
PG 7
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA 3M2XC
UT WOS:000835322400016
OA Bronze
DA 2025-06-11
ER

PT J
AU Radwan, E
   Bakr, MH
   Taha, S
   Sayed, SA
   Farrag, AA
   Ali, M
AF Radwan, Eman
   Bakr, Marwa H.
   Taha, Salma
   Sayed, Sally A.
   Farrag, Alshaimaa A.
   Ali, Maha
TI Inhibition of endoplasmic reticulum stress ameliorates cardiovascular
   injury in a rat model of metabolic syndrome
SO JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
LA English
DT Article
DE Endoplasmic reticulum stress; Metabolic syndrome; TUDCA; Cardiovascular
   disease
ID INSULIN-RESISTANCE; ER STRESS; LIPID-METABOLISM; DISEASE; GLUCOSE;
   HEART; LIVER; RISK; ATHEROSCLEROSIS; ENDOTHELIUM
AB Metabolic (Met) syndrome is characterized by hypertension, insulin resistance and dyslipidaemia with high risk of cardiovascular disease. Endoplasmic reticulum (ER) stress is a key contributor in the pathogenesis of Met syndrome. The current study investigates the effect of Tauroursodeoxycholate (TUDCA), an ER stress inhibitor, on Met syndrome-induced cardiovascular complications and the possible underlying signalling mechanisms. Met syndrome was induced in rats, which were then treated with TUDCA. Body weight, blood pressure, glucose tolerance and insulin tolerance tests were performed. ER stress, survival and oxidative stress markers were measured in heart and aorta tissue. The results showed that TUDCA improved metabolic parameters in rats with Met syndrome. Treatment mitigated the Met syndrome-induced cardiovascular complications through upregulating survival markers and downregulating ER and oxidative stress markers. These results highlight the protective effect of ER stress inhibition as a potential target in the management of cardiovascular complications associated with Met syndrome.
C1 [Radwan, Eman; Ali, Maha] Assiut Univ, Fac Med, Dept Med Biochem, Assiut, Egypt.
   [Taha, Salma] Assiut Univ, Fac Med, Dept Cardiol, Assiut, Egypt.
   [Sayed, Sally A.] Assiut Univ, Fac Med, Dept Physiol, Assiut, Egypt.
   [Bakr, Marwa H.; Farrag, Alshaimaa A.] Assiut Univ, Fac Med, Dept Histol, Assiut, Egypt.
C3 Egyptian Knowledge Bank (EKB); Assiut University; Egyptian Knowledge
   Bank (EKB); Assiut University; Egyptian Knowledge Bank (EKB); Assiut
   University; Egyptian Knowledge Bank (EKB); Assiut University
RP Ali, M (corresponding author), Assiut Univ, Assiut 71515, Egypt.
EM mahaali@aun.edu.eg
RI Radwan, Eman/ABA-3489-2021
OI Ali, Maha/0000-0002-3530-4536; Radwan, Eman/0000-0003-3550-3970; Farrag,
   Alshaimaa A. M./0009-0007-0696-853X; bakr, Marwa
   hassan/0000-0001-8833-7916
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NR 67
TC 18
Z9 20
U1 0
U2 11
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 0022-2828
EI 1095-8584
J9 J MOL CELL CARDIOL
JI J. Mol. Cell. Cardiol.
PD JUN
PY 2020
VL 143
BP 15
EP 25
DI 10.1016/j.yjmcc.2020.04.020
PG 11
WC Cardiac & Cardiovascular Systems; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Cell Biology
GA OD5XT
UT WOS:000579927300002
PM 32311415
DA 2025-06-11
ER

PT J
AU Tokuda, F
   Sando, Y
   Matsui, H
   Yokoyama, T
AF Tokuda, Fumie
   Sando, Yoshichika
   Matsui, Hiroki
   Yokoyama, Tomoyuki
TI N Epsilon-(Hexanoyl) Lysine, A New Oxidative Stress Marker, is Increased
   in Metabolic Syndrome, but not in Obstructive Sleep Apnea
SO AMERICAN JOURNAL OF THE MEDICAL SCIENCES
LA English
DT Article
DE Oxidative stress; Antioxidant status; Metabolic syndrome
ID DNA-DAMAGE; CARDIOVASCULAR-DISEASE; ANTIOXIDANT CAPACITY;
   ATHEROSCLEROSIS; ACCUMULATION; HYPOTHESIS; MORTALITY; EXCRETION;
   F2-ALPHA; EXERCISE
AB Background: It is well known that oxidative stress is induced by metabolic syndrome (MetS), leading to cardiovascular diseases. Oil the other hand, obstructive sleep apnea syndrome (OSAS) is frequently complicated with MetS, and OSAS is also considered to induce oxidative stress. Thus, we examined the plasma and urine markers of oxidative stress and antioxidant starus in patients with OSAS with or without MetS. Methods: Sixty-nine Japanese men suspected of having OSAS were recruited. We divided all patients into 3 groups: nonobese patients, obese patients without MetS, and patients with MetS. Oxidative stress markers, plasma and urine 8-hydroxydeoxyguanosine (8-OHdG) and plasma N epsilon-(hexanoyl) lysine (HEL), and an antioxidant status marker, plasma total antioxidant status, were measured by enzyme-linked immunosorbent assay. Results: The plasma HEL level was significantly increased in patients with MetS, whereas neither plasma and urine 8-OHdG levels nor plasma total antioxidant status level was different in patients with MetS. Furthermore, the plasma HEL level was significantly and positively correlated with tasting plasma glucose, scrum insulin, and homeostasis model assessment-insulin resistance index in all subjects. Conclusions: The oxidative stress is strongly associated with the presence of MetS but not related to the presence or severity of OSAS. Furthemore, we demonstrated that the plasma concentration of HEL is a more sensitive biomarker of oxidative stress in patients with MetS than the plasma and Urine levels of 8-OHdG.
C1 [Tokuda, Fumie; Matsui, Hiroki; Yokoyama, Tomoyuki] Gunma Univ, Sch Hlth Sci, Dept Lab Sci, Maebashi, Gunma 3718511, Japan.
   [Sando, Yoshichika] Koyagi Clin, Takasaki, Gunma, Japan.
C3 Gunma University
RP Yokoyama, T (corresponding author), Gunma Univ, Sch Hlth Sci, Dept Lab Sci, 3-39-15 Showa Machi, Maebashi, Gunma 3718511, Japan.
EM yokoyamt@showa.gunma-u.ac.jp
RI Matsui, Hiroki/P-4033-2019
OI Matsui, Hiroki/0000-0003-3243-333X
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NR 32
TC 24
Z9 24
U1 0
U2 6
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0002-9629
EI 1538-2990
J9 AM J MED SCI
JI Am. J. Med. Sci.
PD AUG
PY 2009
VL 338
IS 2
BP 127
EP 133
DI 10.1097/MAJ.0b013e3181a478e5
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 486VI
UT WOS:000269227900010
PM 19590428
DA 2025-06-11
ER

PT J
AU Firth, J
   Veronese, N
   Cotter, J
   Shivappa, N
   Hebert, JR
   Ee, C
   Smith, L
   Stubbs, B
   Jackson, SE
   Sarris, J
AF Firth, Joseph
   Veronese, Nicola
   Cotter, Jack
   Shivappa, Nitin
   Hebert, James R.
   Ee, Carolyn
   Smith, Lee
   Stubbs, Brendon
   Jackson, Sarah E.
   Sarris, Jerome
TI What Is the Role of Dietary Inflammation in Severe Mental Illness? A
   Review of Observational and Experimental Findings
SO FRONTIERS IN PSYCHIATRY
LA English
DT Review
DE nutrition; schizophrenia; bipolar disorder; nutrients; vitamin
ID MAJOR DEPRESSIVE DISORDER; RANDOMIZED CONTROLLED-TRIAL; BIPOLAR
   DISORDER; METABOLIC SYNDROME; SEGUIMIENTO-UNIVERSIDAD; COGNITIVE
   IMPAIRMENT; HEALTH PROBLEMS; AGED WOMEN; SCHIZOPHRENIA; ASSOCIATION
AB Severe mental illnesses (SMI), including major depressive disorder, bipolar disorder, and schizophrenia, are associated with increased inflammation. Given diet's role in modulating inflammatory processes, excessive calorie-dense, nutrient-deficient processed food intake may contribute toward the heightened inflammation observed in SMI. This review assesses the evidence from observational and experimental studies to investigate how diet may affect physical and mental health outcomes in SMI through inflammation-related pathways. Cross-sectional studies indicate that individuals with SMI, particularly schizophrenia, consume more pro-inflammatory foods and fewer anti-inflammatory nutrients than the general population. Cohort studies indicate that high levels of dietary inflammation are associated with increased risk of developing depression, but there is currently a lack of evidence for schizophrenia or bipolar disorder. Randomized controlled trials show that dietary interventions improve symptoms of depression, but none have tested the extent to which these benefits are due to changes in inflammation. This review summarizes evidence on dietary inflammation in SMI, explores the directionality of these links, and discusses the potential use of targeted nutritional interventions for improving psychological well-being and physical health outcomes in SMI. Establishing the extent to which diet explains elevated levels of inflammatory markers observed in SMI is a priority for future research.
C1 [Firth, Joseph; Ee, Carolyn; Sarris, Jerome] Western Sydney Univ, NICM Hlth Res Inst, Westmead, NSW, Australia.
   [Firth, Joseph] Univ Manchester, Fac Biol Med & Hlth, Div Psychol & Mental Hlth, Manchester, Lancs, England.
   [Veronese, Nicola] IRCCS S de Bellis, Res Hosp, Lab Nutr Biochem, Castellana Grotte, Italy.
   [Veronese, Nicola] CNR, Neurosci Inst, Aging Branch, Padua, Italy.
   [Cotter, Jack] Cambridge Cognit, Cambridge, England.
   [Shivappa, Nitin; Hebert, James R.] Univ South Carolina, Arnold Sch Publ Hlth, Canc Prevent & Control Program, Columbia, SC 29208 USA.
   [Shivappa, Nitin; Hebert, James R.] Univ South Carolina, Arnold Sch Publ Hlth, Dept Epidemiol & Biostat, Columbia, SC 29208 USA.
   [Shivappa, Nitin; Hebert, James R.] Connecting Hlth Innovat LLC, Columbia, SC USA.
   [Smith, Lee] Anglia Ruskin Univ, Cambridge Ctr Sport & Exercise Sci, Cambridge, England.
   [Stubbs, Brendon] South London & Maudsley NHS Fdn Trust, Physiotherapy Dept, London, England.
   [Stubbs, Brendon] Kings Coll London, Inst Psychiat Psychol & Neurosci, Hlth Serv & Populat Res Dept, London, England.
   [Jackson, Sarah E.] UCL, Dept Behav Sci & Hlth, London, England.
   [Sarris, Jerome] Univ Melbourne, Melbourne Clin, Professorial Unit, Dept Psychiat, Melbourne, Vic, Australia.
C3 Western Sydney University; University of Manchester; IRCCS Saverio de
   Bellis; Consiglio Nazionale delle Ricerche (CNR); University of South
   Carolina System; University of South Carolina Columbia; University of
   South Carolina System; University of South Carolina Columbia; Connecting
   Health Innovations LLC; Anglia Ruskin University; South London &
   Maudsley NHS Trust; University of London; King's College London;
   University of London; University College London; University of Melbourne
RP Firth, J (corresponding author), Western Sydney Univ, NICM Hlth Res Inst, Westmead, NSW, Australia.; Firth, J (corresponding author), Univ Manchester, Fac Biol Med & Hlth, Div Psychol & Mental Hlth, Manchester, Lancs, England.
EM J.Firth@Westernsydney.edu.au
RI Firth, Joseph/JOZ-1679-2023; Hebert, James/IUO-5628-2023; Ee,
   Carolyn/V-5070-2019; Veronese, Nicola/K-4343-2018; Shivappa,
   Nitin/X-2215-2018; Stubbs, Brendon/X-1904-2018; Smith,
   Lee/JPA-1418-2023; Jackson, Sarah/J-9046-2019; Stubbs,
   Brendon/C-5696-2015
OI Smith, Lee/0000-0002-5340-9833; Jackson, Sarah/0000-0001-5658-6168; Ee,
   Carolyn/0000-0002-3363-9199; Stubbs, Brendon/0000-0001-7387-3791
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NR 93
TC 64
Z9 70
U1 0
U2 11
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-0640
J9 FRONT PSYCHIATRY
JI Front. Psychiatry
PD MAY 15
PY 2019
VL 10
AR 350
DI 10.3389/fpsyt.2019.00350
PG 9
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA HY5DX
UT WOS:000468148600001
PM 31156486
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Shimoura, N
   Nagai, H
   Fujiwara, S
   Jimbo, H
   Nishigori, C
AF Shimoura, Noriko
   Nagai, Hiroshi
   Fujiwara, Susumu
   Jimbo, Haruki
   Nishigori, Chikako
TI Exacerbation and Prolongation of Psoriasiform Inflammation in Diabetic
   Obese Mice: A Synergistic Role of CXCL5 and Endoplasmic Reticulum Stress
SO JOURNAL OF INVESTIGATIVE DERMATOLOGY
LA English
DT Article
ID ADIPOSE-TISSUE; ACID; ACTIVATION; INHIBITION; RECEPTORS; CELLS
AB Accumulating evidence suggests that psoriasis is frequently accompanied by metabolic disorders, such as obesity and diabetes. However, the mechanisms underlying the association between increased psoriasis severity and concomitant metabolic syndrome have not been fully clarified. Herein, we show that imiquimod-induced psoriasiform inflammation was exacerbated and prolonged in diabetic obese mice compared to that in control mice, accompanied by remarkably increased lesional expressions of Cxcl5 and 11-1b. Notably, a large number of CXCL5(+) Ly6G(+) cells infiltrated the dermis and subcutaneous fat tissue of the diabetic obese mice. Most macrophages in the subcutaneous fat tissues of the diabetic obese mice were positive for expression of IL-1 beta and GRP78/Bip, an endoplasmic reticulum stress marker. Depletion of Ly6G(+) cells and macrophages diminished the imiquimod-induced psoriasiform inflammation. Further, CXCL5 potentiated the secretion of IL-1 beta from macrophages and palmitic acid, a fatty acid released from subcutaneous adipocytes, further enhanced IL-1 beta secretion via endoplasmic reticulum stress induction. Combined with the fact that the serum levels of both CXCL5 and palmitic acid are significantly elevated in patients with metabolic syndrome, our results suggest a role for CXCL5 and endoplasmic reticulum stress in the increase of psoriasis severity of patients with concomitant metabolic syndrome.
C1 [Shimoura, Noriko; Nagai, Hiroshi; Fujiwara, Susumu; Jimbo, Haruki; Nishigori, Chikako] Kobe Univ, Grad Sch Med, Dept Internal Related, Div Dermatol, Kobe, Hyogo, Japan.
C3 Kobe University
RP Nagai, H (corresponding author), Kobe Univ, Grad Sch Med, Dept Internal Related, Div Dermatol,Chuo Ku, 7-5-1 Kusunoki Cho, Kobe, Hyogo 6500017, Japan.
EM hnagai@med.kobe-u.ac.jp
OI Fujiwara, Susumu/0000-0002-5220-713X
FU Japanese Society for the Promotion of Science KAKENHI [JP 25461692]
FX This study was supported by the Japanese Society for the Promotion of
   Science KAKENHI grant number JP 25461692.
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NR 29
TC 14
Z9 16
U1 0
U2 6
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0022-202X
EI 1523-1747
J9 J INVEST DERMATOL
JI J. Invest. Dermatol.
PD APR
PY 2018
VL 138
IS 4
BP 854
EP 863
DI 10.1016/j.jid.2017.10.023
PG 10
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA GA2GO
UT WOS:000428135400023
PM 29111234
OA Bronze
DA 2025-06-11
ER

PT J
AU Kubota, Y
   Goto, T
   Hagiya, Y
   Chohnan, S
   Toyoda, A
AF Kubota, Yoshifumi
   Goto, Tatsuhiko
   Hagiya, Yuki
   Chohnan, Shigeru
   Toyoda, Atsushi
TI Decreased hepatic contents of coenzyme A molecular species in mice after
   subchronic mild social defeat stress
SO STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS
LA English
DT Article
DE Coenzyme A; depression; hypothalamus; liver; mouse; social defeat stress
ID HYPOTHALAMIC MALONYL-COA; SUSCEPTIBILITY; BEHAVIOR; TISSUE; LEPTIN
AB Social stress may precipitate psychiatric disorders such as depression, which is related to the occurrence of the metabolic syndrome, including obesity and type 2 diabetes. We have evaluated the effects of social stress on central and peripheral metabolism using a model of depression in mice. In the present study, we focused on coenzyme A (CoA) molecular species [i.e. non-esterified CoA (CoASH), acetyl-CoA and malonyl-CoA] which play important roles in numerous metabolic pathways, and we analyzed changes in expression of these molecules in the hypothalamus and liver of adult male mice (C57BL/6J) subjected to 10 days of subchronic mild social defeat stress (sCSDS) with ICR mice as aggressors. Mice (n=12) exposed to showed hyperphagia- and polydipsia-like symptoms and increased body weight gain compared with control mice which were not affected by exposure to ICR mice (n=12). To elucidate the underlying metabolic features in the sCSDS model, acetyl-CoA, malonyl-CoA and CoASH tissue levels were analyzed using the acyl-CoA cycling method. The levels of hypothalamic malonyl-CoA, which decreases feeding behavior, were not influenced by sCSDS. However, sCSDS reduced levels of acetyl-CoA, malonyl-CoA and total CoA (sum of the three CoA molecular species) in the liver. Hence, hyperphagia-like symptoms in sCSDS mice evidently occurred independently of hypothalamic malonyl-CoA, but might consequently lead to down-regulation of hepatic CoA via altered expression of nudix hydrolase 7. Future studies should investigate the molecular mechanism(s) underlying the down-regulation of liver CoA pools in sCSDS mice.
C1 [Kubota, Yoshifumi; Goto, Tatsuhiko; Hagiya, Yuki; Chohnan, Shigeru; Toyoda, Atsushi] Ibaraki Univ, Coll Agr, Ami, Ibaraki 30003, Japan.
   [Kubota, Yoshifumi] Swine Res Sec, Cent Res Inst Feed & Livestock, Natl Federat Agr Cooperat Assoc, Tsukuba, Ibaraki, Japan.
   [Goto, Tatsuhiko; Chohnan, Shigeru; Toyoda, Atsushi] Ibaraki Univ Cooperat Agr & Med Sci IUCAM, Ami, Ibaraki, Japan.
   [Chohnan, Shigeru; Toyoda, Atsushi] Tokyo Univ Agr & Technol, United Grad Sch Agr Sci, Fuchu, Tokyo, Japan.
C3 Ibaraki University; Ibaraki University; Tokyo University of Agriculture
   & Technology
RP Toyoda, A (corresponding author), Ibaraki Univ, Coll Agr, 3-21-1 Chuo Ami, Ibaraki 3000393, Japan.
EM atsushi.toyoda.0516@vc.ibaraki.ac.jp
RI Goto, Tatsuhiko/AAJ-3498-2020; Chohnan, Shigeru/W-1580-2019
OI Goto, Tatsuhiko/0000-0002-1787-7533; Toyoda,
   Atsushi/0000-0002-0245-3244; Chohnan_, Shigeru/0000-0002-4624-927X
FU Ibaraki University; Agriculture and Medical Science (IUCAM) (The MEXT,
   Japan); Research Project on the Development of Agricultural Products and
   Foods with Health-promoting benefits (NARO) (The MAFF, Japan); Council
   for Science, Technology and Innovation (CSTI)
FX The authors declare no conflicts of interest. This research was
   supported in part by an Ibaraki University Cooperation between
   Agriculture and Medical Science (IUCAM) (The MEXT, Japan), the Research
   Project on the Development of Agricultural Products and Foods with
   Health-promoting benefits (NARO) (The MAFF, Japan), and the Council for
   Science, Technology and Innovation (CSTI) under the Cross-ministerial
   Strategic Innovation Promotion Program (SIP) "Technologies for creating
   next-generation agriculture, forestry and fisheries" (Bio-oriented
   Technology Research Advancement Institution, NARO) (The Cabinet Office,
   Japan).
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NR 26
TC 7
Z9 7
U1 0
U2 3
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 1025-3890
EI 1607-8888
J9 STRESS
JI Stress
PD MAR
PY 2016
VL 19
IS 2
BP 192
EP 197
DI 10.3109/10253890.2015.1137558
PG 6
WC Behavioral Sciences; Endocrinology & Metabolism; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Behavioral Sciences; Endocrinology & Metabolism; Neurosciences &
   Neurology
GA DK1GA
UT WOS:000374659300007
PM 26864137
DA 2025-06-11
ER

PT J
AU Penna, C
   Pagliaro, P
AF Penna, Claudia
   Pagliaro, Pasquale
TI Endothelial Dysfunction: Redox Imbalance, NLRP3 Inflammasome, and
   Inflammatory Responses in Cardiovascular Diseases
SO ANTIOXIDANTS
LA English
DT Review
DE nitric oxide; oxidative stress; NLRP3 inflammasome; antioxidant
   treatments; metabolic syndrome; ischemia/reperfusion injury
ID MYOCARDIAL-ISCHEMIA-REPERFUSION; GLUTATHIONE-PEROXIDASE DEFICIENCY;
   PERMEABILITY TRANSITION PORE; NITRIC-OXIDE SYNTHASE; OXIDATIVE STRESS;
   ISCHEMIA/REPERFUSION INJURY; INDUCED ATHEROSCLEROSIS; TRANSLATIONAL
   EVIDENCE; VASCULAR ENDOTHELIUM; DIETARY NITRATE
AB Endothelial dysfunction (ED) is characterized by an imbalance between vasodilatory and vasoconstrictive factors, leading to impaired vascular tone, thrombosis, and inflammation. These processes are critical in the development of cardiovascular diseases (CVDs) such as atherosclerosis, hypertension and ischemia/reperfusion injury (IRI). Reduced nitric oxide (NO) production and increased oxidative stress are key contributors to ED. Aging further exacerbates ED through mitochondrial dysfunction and increased oxidative/nitrosative stress, heightening CVD risk. Antioxidant systems like superoxide-dismutase (SOD), glutathione-peroxidase (GPx), and thioredoxin/thioredoxin-reductase (Trx/TXNRD) pathways protect against oxidative stress. However, their reduced activity promotes ED, atherosclerosis, and vulnerability to IRI. Metabolic syndrome, comprising insulin resistance, obesity, and hypertension, is often accompanied by ED. Specifically, hyperglycemia worsens endothelial damage by promoting oxidative stress and inflammation. Obesity leads to chronic inflammation and changes in perivascular adipose tissue, while hypertension is associated with an increase in oxidative stress. The NLRP3 inflammasome plays a significant role in ED, being triggered by factors such as reactive oxygen and nitrogen species, ischemia, and high glucose, which contribute to inflammation, endothelial injury, and exacerbation of IRI. Treatments, such as N-acetyl-L-cysteine, SGLT2 or NLRP3 inhibitors, show promise in improving endothelial function. Yet the complexity of ED suggests that multi-targeted therapies addressing oxidative stress, inflammation, and metabolic disturbances are essential for managing CVDs associated with metabolic syndrome.
C1 [Penna, Claudia; Pagliaro, Pasquale] Univ Turin, Dept Clin & Biol Sci, I-10043 Orbassano, Italy.
   [Penna, Claudia; Pagliaro, Pasquale] Natl Inst Cardiovasc Res INRC, I-40126 Bologna, Italy.
C3 University of Turin
RP Pagliaro, P (corresponding author), Univ Turin, Dept Clin & Biol Sci, I-10043 Orbassano, Italy.; Pagliaro, P (corresponding author), Natl Inst Cardiovasc Res INRC, I-40126 Bologna, Italy.
EM claudia.penna@unito.it; pasquale.pagliaro@unito.it
RI Penna, Claudia/J-5103-2018
FU University of Turin, Ricerca Locale and Progetti PRIN:
   PAGP_PRIN_2022_23_01 [PAGP_PRIN_2022_23_01-2022AA37N3,
   PENC_PRIN_2022_23_01-2022S74XWB]; University of Turin
FX The authors are supported by the University of Turin, Ricerca Locale and
   Progetti PRIN: PAGP_PRIN_2022_23_01-2022AA37N3 and
   PENC_PRIN_2022_23_01-2022S74XWB.
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NR 229
TC 2
Z9 2
U1 4
U2 4
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD FEB 23
PY 2025
VL 14
IS 3
AR 256
DI 10.3390/antiox14030256
PG 30
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA 0QG6T
UT WOS:001453446600001
PM 40227195
OA gold
DA 2025-06-11
ER

PT J
AU Bostan, C
   Kaya, A
   Yigit, Z
AF Bostan, Cem
   Kaya, Aysem
   Yigit, Zerrin
TI Differences Between Morbid Obesity With Metabolic Syndrome and
   Overweight Turkish Adult Participants in Multiple Atherosclerotic
   Cardiovascular Disease Risk Factors
SO ANGIOLOGY
LA English
DT Article
DE obesity; metabolic syndrome; atherogenic dyslipidemia; oxidative stress;
   Turkey
ID HIGH-DENSITY-LIPOPROTEIN; CORONARY-HEART-DISEASE; C-REACTIVE PROTEIN;
   OXIDATIVE STRESS; URIC-ACID; CLINICAL-SIGNIFICANCE; INSULIN-RESISTANCE;
   CHOLESTEROL; MORTALITY; LEVEL
AB Obesity and metabolic syndrome (MetS) are public health problems and are increasing globally. We assessed the differences in lipid profiles through lipid testing, thrombotic and inflammatory parameters, and oxidative stress indexes between overweight and obese patients with MetS in a Turkish adult population. We included 100 obese (body mass index [BMI] >30 kg/m(2)) patients with MetS (66 women, 34 men, mean age 54.0 +/- 10.1 years) and 15 overweight (BMI 25-30 kg/m(2)) individuals (11 women, 4 men, mean age 50.2 +/- 14.5 years) as controls. The group with MetS had significantly higher levels of glycaemia, uric acid, high-sensitivity C-reactive protein, homocysteine, fibrinogen, total cholesterol, low-density lipoprotein cholesterol (LDL-C), triglycerides, small dense LDL, oxidized LDL, apolipoprotein B (Apo B), lipoprotein (a), small and intermediate high-density lipoprotein (HDL) particles, oxidative stress index, and significantly lower levels of HDL-cholesterol (HDL-C), Apo A, and large HDL particles. In conclusion, obesity with MetS increase atherogenic dyslipidemia and thrombotic, inflammatory and oxidative stress biomarkers. Furthermore, obesity with MetS decreases protective mechanisms of atherosclerosis. We should at least try to prevent overweight individuals from becoming obese with MetS.
C1 [Bostan, Cem; Yigit, Zerrin] Istanbul Univ Cerrahpasa Inst Cardiol, Dept Cardiol, TR-34350 Istanbul, Turkey.
   [Kaya, Aysem] Istanbul Univ Cerrahpasa Inst Cardiol, Dept Biochem, Istanbul, Turkey.
RP Bostan, C (corresponding author), Istanbul Univ Cerrahpasa Inst Cardiol, Dept Cardiol, TR-34350 Istanbul, Turkey.
EM bostancem@yahoo.com
RI Bostan, Cem/AAC-5345-2021; Kaya, Aysem/N-4974-2015
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NR 48
TC 1
Z9 2
U1 0
U2 7
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0003-3197
EI 1940-1574
J9 ANGIOLOGY
JI Angiology
PD FEB
PY 2021
VL 72
IS 2
BP 131
EP 137
DI 10.1177/0003319720970161
PG 7
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA PR5WS
UT WOS:000607307200003
PM 33143460
DA 2025-06-11
ER

PT J
AU Kim, YJ
   Kim, SM
   Jeong, DH
   Lee, SK
   Ahn, ME
   Ryu, OH
AF Kim, Yeo Jin
   Kim, Sang Mi
   Jeong, Dae Hyun
   Lee, Sang-Kyu
   Ahn, Moo-Eob
   Ryu, Ohk-Hyun
TI Associations between metabolic syndrome and type of dementia: analysis
   based on the National Health Insurance Service database of Gangwon
   province in South Korea
SO DIABETOLOGY & METABOLIC SYNDROME
LA English
DT Article
DE Metabolic syndrome; National Health Insurance Service; Dementia risk;
   Alzheimer's disease; Vascular dementia
ID ALZHEIMERS-DISEASE; VASCULAR DEMENTIA; RISK-FACTORS; DIABETES-MELLITUS;
   COGNITIVE DECLINE; LATE-LIFE; PARKINSONS-DISEASE; OXIDATIVE STRESS;
   APOLIPOPROTEIN-E; ISCHEMIC-STROKE
AB Background: Metabolic syndrome is a cluster of conditions that occur together, increasing the risk of cardiovascular disease. However, the relationship between metabolic syndrome and dementia has remained controversial. Using nationwide population cohort data, we investigated the association between metabolic syndrome and dementia, according to the dementia type.
   Methods: We analyzed data of 84,144 individuals, in the aged group of more than 60 years, between January 1, 2009, to December 31, 2009, at Gangwon province by using the information of the (Korean) National Health Insurance Service. After eight years of gap, in 2017, we investigated the relationship between metabolic syndrome and dementia. We classified Dementia either as dementia of the Alzheimer type (AD) or vascular dementia (VD). AD and VD were defined as per the criteria of International Classification of Disease, Tenth Revision, Clinical Modification codes. Multiple logistic regression analyses examined the associations between metabolic syndrome or five metabolic syndrome components and dementia. Analyses included factors like age, sex, smoking, alcohol, physical inactivity, previous stroke, and previous cardiac disease.
   Results: Metabolic syndrome was associated with AD (OR = 11.48, 95% CI 9.03-14.59), not with VD. Each of five components of metabolic syndrome were also associated with AD. (high serum triglycerides: OR = 1.87, 95% CI 1.60-2.19; high blood pressure: OR = 1.85, 95% CI 1.55-2.21; high glucose: OR = 1.77, 95% CI 1.52-2.06; abdominal obesity: OR = 1.88, 95% CI 1.57-2.25; low serum high-density lipoprotein cholesterol: OR = 1.91, 95% CI 1.63-2.24) However, among components of metabolic syndrome, only the high glucose level was associated with VD. (OR = 1.26, 95% CI 1.01-1.56) body mass index (BMI), fasting glucose, and smoking were also associated with AD. (BMI: OR = 0.951, 95% CI 0.927-0.975; fasting glucose: OR = 1.003, 95% CI 1.001-1.005; smoking: OR = 1.020, 95% CI 1.003-1.039) A history of the previous stroke was associated with both AD and VD. (AD: OR = 1.827, 95% CI 1.263-2.644; VD: OR 2.775, 95% CI 1.747-4.406)
   Conclusions: Metabolic syndrome was associated with AD but not with VD. Patients with metabolic syndrome had an 11.48 times more likeliness to develop AD compared to those without metabolic syndrome. VD was associated only with several risk factors that could affect the vascular state rather than a metabolic syndrome. We suggested that the associations between metabolic syndrome and dementia would vary depending on the type of dementia.
C1 [Kim, Yeo Jin] Hallym Univ, Chuncheon Sacred Heart Hosp, Coll Med, Dept Neurol, Chunchon, Gangwon Do, South Korea.
   [Kim, Sang Mi] Ewha Womans Univ, Dept Big Data Analyt, Seoul, South Korea.
   [Jeong, Dae Hyun] Res Inst Gangwon, Chunchon, Gangwon Do, South Korea.
   [Lee, Sang-Kyu] Hallym Univ, Chuncheon Sacred Heart Hosp, Coll Med, Dept Psychiat, Chunchon, Gangwon Do, South Korea.
   [Ahn, Moo-Eob] Hallym Univ, Chuncheon Sacred Heart Hosp, Coll Med, Dept Emergency Med, Chunchon, Gangwon Do, South Korea.
   [Ryu, Ohk-Hyun] Hallym Univ, Chuncheon Sacred Heart Hosp, Coll Med, Dept Internal Med,Div Endocrinol & Metab, 77 Sakju Ro, Chunchon 24253, Gangwon Do, South Korea.
C3 Hallym University; Ewha Womans University; Hallym University; Hallym
   University; Hallym University
RP Ryu, OH (corresponding author), Hallym Univ, Chuncheon Sacred Heart Hosp, Coll Med, Dept Internal Med,Div Endocrinol & Metab, 77 Sakju Ro, Chunchon 24253, Gangwon Do, South Korea.
EM ohryu30@gmail.com
RI Lee, Sang/L-8626-2016; Kim, Hee-Jin/P-1903-2015
FU Korea Health Technology R&D Project through the Korea Health Industry
   Development Institute (KHIDI) - Ministry of Health & Welfare, Republic
   of Korea [HI18C1623]; National Research Foundation of Korea (NRF) -
   Korean government [NRF-2017R1C1B2011637, NRF-2019R1H1A1035599]
FX This research was supported by a grant of the Korea Health Technology
   R&D Project through the Korea Health Industry Development Institute
   (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea
   (grant number: HI18C1623), and the National Research Foundation of Korea
   (NRF) grant funded by the Korean government (NRF-2017R1C1B2011637 &
   NRF-2019R1H1A1035599).
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NR 84
TC 42
Z9 46
U1 4
U2 30
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1758-5996
J9 DIABETOL METAB SYNDR
JI Diabetol. Metab. Syndr.
PD JAN 6
PY 2021
VL 13
IS 1
AR 4
DI 10.1186/s13098-020-00620-5
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA PP1GF
UT WOS:000605616300001
PM 33407809
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Hung, CS
   Wu, YW
   Huang, JY
   Hsu, PY
   Chen, MF
AF Hung, Chi-Sheng
   Wu, Yen-Wen
   Huang, Jei-Yie
   Hsu, Pei-Ying
   Chen, Ming-Fong
TI Evaluation of Circulating Adipokines and Abdominal Obesity as Predictors
   of Significant Myocardial Ischemia Using Gated Single-Photon Emission
   Computed Tomography
SO PLOS ONE
LA English
DT Article
ID ACID-BINDING PROTEIN; CORONARY-ARTERY-DISEASE; ASYMPTOMATIC
   POSTMENOPAUSAL WOMEN; PROATRIAL NATRIURETIC PEPTIDE; SERUM CHEMERIN
   LEVELS; METABOLIC SYNDROME; ADIPOSE-TISSUE; INFLAMMATION; ADIPOCYTE;
   ASSOCIATION
AB Objective: Coronary artery disease (CAD) is associated with abdominal obesity and metabolic syndrome. Adipocytes secrete adipokines, including the newly discovered adipocyte fatty acid binding protein (A-FABP) and chemerin. Adipokines contribute to the pathogenesis of CAD. In patients with CAD, the presence of significant ischemia predicts adverse outcomes. It is unknown whether adipokines can be better predictors of the presence of significant myocardial ischemia than conventional risk factors. This study aimed to compare adipokines with clinical risk factors and abdominal obesity as predictive factors for significant myocardial ischemia.
   Methods: One hundred and ninety-six adults with suspected, but unproven, CAD were consecutively enrolled. The main measures were clinical and biochemical parameters and stress myocardial perfusion imaging with gated myocardial perfusion single-photon emission computed tomography (SPECT), with computed tomography (CT) attenuation correction. The abdominal visceral fat area was examined using a hybrid SPECT/CT scanner. Serum levels of high-sensitivity C-reactive protein (hs-CRP) and adipokines (adiponectin, A-FABP, and chemerin) were evaluated.
   Results: A-FABP levels correlated significantly with adiponectin, hs-CRP, body mass index, waist circumference, and visceral fat area. A-FABP was significantly associated with metabolic syndrome (OR 3.2, 95% CI 1.6-6.4, p = 0.001), significant myocardial ischemia (OR 1.9, 95% CI 1.0-3.4, p = 0.05), and stress lung-to-heart ratio (beta = 0.03, p = 0.03) on SPECT. Chemerin was significantly associated with serum triglyceride levels but not with metabolic syndrome, significant ischemia, or stress lung-to-heart ratio on SPECT. A-FABP was better at detecting significant inducible ischemia than other biomarkers, although this was a modest improvement (area under ROC curve 0.579, 95% CI 0.46-0.69).
   Conclusions: Serum A-FABP concentrations correlate significantly with visceral fat area, metabolic syndrome, and predicted significant myocardial ischemia on SPECT. This may help to more accurately assess CAD risk, especially in patients with metabolic syndrome.
C1 [Hung, Chi-Sheng; Wu, Yen-Wen; Chen, Ming-Fong] Natl Taiwan Univ Hosp, Dept Internal Med, Div Cardiol, Taipei 100, Taiwan.
   [Hung, Chi-Sheng; Wu, Yen-Wen; Huang, Jei-Yie; Chen, Ming-Fong] Natl Taiwan Univ, Coll Med, Taipei 10764, Taiwan.
   [Wu, Yen-Wen; Huang, Jei-Yie] Natl Taiwan Univ Hosp, Dept Nucl Med, Taipei 100, Taiwan.
   [Wu, Yen-Wen] Far Eastern Mem Hosp, Cardiovasc Med Ctr, Div Cardiol, New Taipei City, Taiwan.
   [Wu, Yen-Wen] Far Eastern Mem Hosp, Dept Nucl Med, New Taipei City, Taiwan.
   [Wu, Yen-Wen] Natl Yang Ming Univ, Sch Med, Taipei 112, Taiwan.
   [Hsu, Pei-Ying] Natl Taiwan Univ Hosp, Dept Nucl Med, Yun Lin Branch, Douliou City, Taiwan.
C3 National Taiwan University; National Taiwan University Hospital;
   National Taiwan University; National Taiwan University; National Taiwan
   University Hospital; Far Eastern Memorial Hospital; Far Eastern Memorial
   Hospital; National Yang Ming Chiao Tung University; National Taiwan
   University; National Taiwan University Hospital
RP Wu, YW (corresponding author), Natl Taiwan Univ Hosp, Dept Internal Med, Div Cardiol, Taipei 100, Taiwan.
EM wuyw0502@gmail.com
RI Chung, Chen-Shuan/LKK-8320-2024
OI Huang, Jei-Yie/0009-0002-0985-4005; WU, YEN-WEN/0000-0003-1520-1166
FU National Science Council, Taiwan [NSC 101-2314-B-418-012-MY3]; National
   Taiwan University Hospital, Yunlin Branch [NTUH.YL 98.S017]
FX This work was supported by research grants from the National Science
   Council, Taiwan (NSC 101-2314-B-418-012-MY3), and National Taiwan
   University Hospital, Yunlin Branch (NTUH.YL 98.S017). The funders had no
   role in study design, data collection and analysis, decision to publish,
   or preparation of the manuscript.
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NR 45
TC 9
Z9 9
U1 0
U2 4
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAY 19
PY 2014
VL 9
IS 5
AR e97710
DI 10.1371/journal.pone.0097710
PG 8
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA AN9SK
UT WOS:000340948600061
PM 24842767
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Ham, OK
AF Ham, Ok Kyung
TI Socioeconomic and Behavioral Characteristics Associated With Metabolic
   Syndrome Among Overweight/Obese School-age Children
SO JOURNAL OF CARDIOVASCULAR NURSING
LA English
DT Article
DE childhood obesity; eating behaviors; metabolic syndrome; socioeconomic
   status
ID PERCEIVED STRESS; CHILDHOOD OBESITY; SLEEP DURATION; RISK-FACTORS;
   PREVALENCE; HEALTH; ADIPOSITY
AB Background: Obesity in children comprises a significant public health concern in Korea. As with increased prevalence of overweight and obesity among children, risk factors for metabolic syndrome (MetS) have also increased in this population. Objective: The purpose was to examine behavioral and socioeconomic factors that were associated with biomarkers of MetS among overweight/obese school-age children. Methods: A cross-sectional study was conducted, and a convenience sample of 75 overweight/obese school-age children participated. Socioeconomic and behavioral characteristics, anthropometric measurements, and physiologic examinations were studied. The data were analyzed using an analysis of covariance and logistic regression. Results: Metabolic syndrome was diagnosed in 27.8% of our population. Severe stress was significantly associated with elevated systolic blood pressure (P < .05). Among the family characteristics, children's perception of family income (wealthy and very wealthy) and mother's education level (high school or less) were associated with diagnoses of MetS in children (P < .05). Conclusions: The results indicated that certain socioeconomic and behavioral characteristics were associated with risk factors of MetS, and therefore, interventions to modify these risk factors are needed to promote the healthy development of overweight/obese school-age children.
C1 [Ham, Ok Kyung] Inha Univ, Dept Nursing, 100 Inharo, Inchon 22212, South Korea.
C3 Inha University
RP Ham, OK (corresponding author), Inha Univ, Dept Nursing, 100 Inharo, Inchon 22212, South Korea.
EM okkyung@inha.ac.kr
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NR 52
TC 0
Z9 1
U1 0
U2 12
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0889-4655
EI 1550-5049
J9 J CARDIOVASC NURS
JI J. Cardiovasc. Nurs.
PD JAN-FEB
PY 2017
VL 32
IS 1
BP 30
EP 38
DI 10.1097/JCN.0000000000000301
PG 9
WC Cardiac & Cardiovascular Systems; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Cardiovascular System & Cardiology; Nursing
GA EF6MW
UT WOS:000390446200007
PM 26544172
DA 2025-06-11
ER

PT J
AU Primavera, D
   Gonzalez, CA
   Perra, A
   Kalcev, G
   Cantone, E
   Cossu, G
   Holzinger, A
   Carta, MG
   Sancassiani, F
AF Primavera, Diego
   Aviles Gonzalez, Cesar
   Perra, Alessandra
   Kalcev, Goce
   Cantone, Elisa
   Cossu, Giulia
   Holzinger, Anita
   Carta, Mauro Giovanni
   Sancassiani, Federica
TI Virtual Reality Cognitive Remediation in Older Adults with Bipolar
   Disorder: The Effects on Cognitive Performance and Depression in a
   Feasibility Randomized Controlled Trial
SO HEALTHCARE
LA English
DT Article
DE cognitive remediation; virtual reality; advanced technology laboratory;
   elderly
ID SEVERE MENTAL-ILLNESS; CARDIOVASCULAR-DISEASE; SOCIAL DETERMINANTS;
   METABOLIC SYNDROME; NORMATIVE VALUES; DEMENTIA; STATE; METAANALYSIS;
   IMPAIRMENT; MORTALITY
AB Introduction: Dementia, depression, and cardiovascular disease are major public health concerns for older adults, requiring early intervention. This study investigates whether a virtual reality cognitive remediation program (VR-CR) can improve cognitive function and depressive symptoms in older adults, and determines the necessary sample size for future studies. Integrated VR and CR interventions have shown promising outcomes in older adults with neurodegenerative and mental health disorders. Methods: This secondary analysis of a randomized controlled trial involves adults aged 58-75 years with bipolar disorder, excluding those with acute episodes, epilepsy, or severe eye diseases. The experimental group received standard treatment plus VR-CR, while the control group received only standard treatment. Results: No baseline differences were found between the experimental and control groups. No significant improvement was observed in the overall cognitive function test (p = 0.897) or in depressive symptoms (p = 0.322). A phase III efficacy study requires a sample size of 28 participants (alpha = 0.05, beta = 0.20). Conclusions: VR-CR can potentially treat depressive symptoms in adults and older adults, but the results support conducting phase III studies to further investigate these outcomes. However, the improvement in cognitive performance in the elderly is less pronounced than in younger individuals.
C1 [Primavera, Diego; Aviles Gonzalez, Cesar; Perra, Alessandra; Cantone, Elisa; Cossu, Giulia; Carta, Mauro Giovanni; Sancassiani, Federica] Univ Cagliari, Dept Med Sci & Publ Hlth, I-09042 Cagliari, Italy.
   [Aviles Gonzalez, Cesar] Univ Popular Cesar, Dept Nursing, Valledupar 200001, Colombia.
   [Kalcev, Goce] Natl Alliance Neuromuscular Dis & Neurosci GANGL S, Skopje 1000, North Macedonia.
   [Holzinger, Anita] Univ Wien, Dept Med, Spitalgasse 23, A-1090 Vienna, Austria.
C3 University of Cagliari; University of Vienna
RP Gonzalez, CA (corresponding author), Univ Cagliari, Dept Med Sci & Publ Hlth, I-09042 Cagliari, Italy.; Gonzalez, CA (corresponding author), Univ Popular Cesar, Dept Nursing, Valledupar 200001, Colombia.
EM infermiere2020@gmail.com
RI Cossu, Giulia/AIC-4641-2022; Carta, MauroGiovanni/D-9624-2012;
   Primavera, Diego/JEZ-4038-2023; Aviles gonzalez, cesar
   ivan/AAT-8334-2021; Perra, Alessandra/GVU-0704-2022; Kalcev,
   Goce/AAO-5967-2020
OI SANCASSIANI, FEDERICA/0000-0002-7963-5281; Cantone,
   Elisa/0009-0001-5049-4614; Aviles gonzalez, cesar
   ivan/0000-0002-1566-1974; Perra, Alessandra/0000-0001-5791-1655; Cossu,
   Giulia/0000-0002-1245-016X; Kalcev, Goce/0000-0002-0351-6577
FU Fondazione di Sardegna;  [U1307.2023/AI.1282];  [MGB2023.0503]
FX This study is funded by the Fondazione di Sardegna, Grant No.
   U1307.2023/AI.1282.MGB2023.0503.
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NR 68
TC 0
Z9 0
U1 6
U2 10
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2227-9032
J9 HEALTHCARE-BASEL
JI Healthcare
PD SEP
PY 2024
VL 12
IS 17
AR 1753
DI 10.3390/healthcare12171753
PG 10
WC Health Care Sciences & Services; Health Policy & Services
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services
GA F6N1P
UT WOS:001310957100001
PM 39273777
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Hu, F
   Sun, DS
   Wang, KL
   Shang, DY
AF Hu, Fang
   Sun, Dong-Sheng
   Wang, Kai-Li
   Shang, Dan-Ying
TI Nanomedicine of Plant Origin for the Treatment of Metabolic Disorders
SO FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
LA English
DT Review
DE metabolic disorders; medicinal plants; phytochemicals; nano drug; nano
   system
ID NANOSTRUCTURED LIPID CARRIERS; OXIDATIVE STRESS; ORAL DELIVERY; SELENIUM
   NANOPARTICLES; CURCUMIN NANOPARTICLES; THERAPEUTIC-EFFICACY; SILVER
   NANOPARTICLES; INDUCED DYSLIPIDEMIA; INSULIN-RESISTANCE; DIABETES
   TREATMENT
AB Metabolic disorders are major clinical challenges of health that are progressing globally. A concurrence of metabolic disorders such as obesity, insulin resistance, atherogenic dyslipidemia, and systematic hypertension leads to metabolic syndrome. Over the past years, the metabolic syndrome leads to a five- and two-fold rise in diabetes mellitus type II and cardiovascular diseases. Natural products specifically plant extracts have insulin-sensitizing, anti-inflammatory, and antioxidant properties and are also considered as an alternative option due to few adverse effects. Nanotechnology is one of the promising strategies, which improves the effectiveness of treatment and limits side effects. This review mainly focuses on plant extract-based nanosystems in the management of the metabolic syndrome. Numerous nano-drug delivery systems, i.e., liposomes, hydrogel nanocomposites, nanoemulsions, micelles, solid lipid, and core-shell nanoparticles, have been designed using plant extracts. It has been found that most of the nano-formulations successfully reduced oxidative stress, insulin resistance, chronic inflammation, and lipid profile in in vitro and in vivo studies as plant extracts interfere with the pathways of metabolic syndrome. Thus, these novel plant-based nanosystems could act as a promising candidate for clinical applications.
C1 [Hu, Fang] Chunan First Peoples Hosp, Med Dept, Zhejiang Prov Peoples Hosp, Chunan Branch, Hangzhou, Peoples R China.
   [Sun, Dong-Sheng] Zhejiang Prov Peoples Hosp, Affiliated Peoples Hosp, Dept Geriatr Med, Hangzhou Med Coll, Hangzhou, Peoples R China.
   [Wang, Kai-Li] Chunan First Peoples Hosp, Dept Cardiol, Zhejiang Prov Peoples Hosp, Chunan Branch, Hangzhou, Peoples R China.
   [Shang, Dan-Ying] Zhejiang Prov Peoples Hosp, Affiliated Peoples Hosp, Dept Dermatol, Hangzhou Med Coll, Hangzhou, Peoples R China.
C3 Hangzhou Medical College; Zhejiang Provincial People's Hospital;
   Hangzhou Medical College; Zhejiang Provincial People's Hospital;
   Hangzhou Medical College; Zhejiang Provincial People's Hospital;
   Hangzhou Medical College; Zhejiang Provincial People's Hospital
RP Shang, DY (corresponding author), Zhejiang Prov Peoples Hosp, Affiliated Peoples Hosp, Dept Dermatol, Hangzhou Med Coll, Hangzhou, Peoples R China.
EM shangdy1975@163.com
FU Zhejiang Provincial Science and Technology Projects [LGF20H020009]
FX This work was supported by the Zhejiang Provincial Science and
   Technology Projects (No. LGF20H020009 to D-SS).
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NR 119
TC 12
Z9 12
U1 2
U2 30
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-4185
J9 FRONT BIOENG BIOTECH
JI Front. Bioeng. Biotechnol.
PD FEB 11
PY 2022
VL 9
AR 811917
DI 10.3389/fbioe.2021.811917
PG 14
WC Biotechnology & Applied Microbiology; Engineering, Biomedical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Engineering
GA 2Q7RU
UT WOS:000820617000001
PM 35223819
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Song, YQ
   Baranova, A
   Cao, HB
   Yue, WH
   Zhang, FQ
AF Song, Yuqing
   Baranova, Ancha
   Cao, Hongbao
   Yue, Weihua
   Zhang, Fuquan
TI Causal associations between posttraumatic stress disorder and type 2
   diabetes
SO DIABETOLOGY & METABOLIC SYNDROME
LA English
DT Article
DE Posttraumatic stress disorder; Diabetes; Mendelian randomization
ID EARTHQUAKE SURVIVORS; METABOLIC SYNDROME; HORMONE-LEVELS; PTSD
AB Posttraumatic stress disorder (PTSD) patients have a high comorbidity with type 2 diabetes (T2D). Whether PTSD influences the risk of diabetes is still not known. We used GWAS data from European ancestry of PTSD (23,121 cases and 151,447 controls) and T2D (80,154 cases and 853,816 controls) to investigate the bidirectional associations between PTSD and T2D by the Mendelian randomization (MR) analysis. We showed that PTSD was causally associated with higher odds of T2D (OR = 1.04, 95% CI: 1.01-1.06, P = 0.0086), but not vice versa. Our study suggests that PTSD may increase the risk of T2D. PTSD sufferers should be screened for T2D and its precursor known as metabolic syndrome.
C1 [Song, Yuqing; Yue, Weihua] Peking Univ Sixth Hosp, Inst Mental Hlth, Beijing 100191, Peoples R China.
   [Song, Yuqing; Yue, Weihua] Peking Univ, Peking Univ Hosp 6, Natl Clin Res Ctr Mental Disorders, NHC Key Lab Mental Hlth, Beijing 100191, Peoples R China.
   [Baranova, Ancha; Cao, Hongbao] George Mason Univ, Sch Syst Biol, Manassas, VA 20110 USA.
   [Baranova, Ancha] Res Ctr Med Genet, Moscow 115478, Russia.
   [Yue, Weihua] Peking Univ, PKU IDG McGovern Inst Brain Res, Beijing 100871, Peoples R China.
   [Yue, Weihua] Chinese Inst Brain Res, Beijing 102206, Peoples R China.
   [Zhang, Fuquan] Nanjing Med Univ, Affiliated Brain Hosp, Inst Neuropsychiat, Nanjing 210029, Peoples R China.
   [Zhang, Fuquan] Nanjing Med Univ, Dept Psychiat, Affiliated Brain Hosp, 264 Guangzhou Rd, Nanjing 210029, Peoples R China.
C3 Peking University; George Mason University; Research Centre for Medical
   Genetics; Peking University; Chinese Institute for Brain Research,
   Beijing; Nanjing Medical University; Nanjing Medical University
RP Zhang, FQ (corresponding author), Nanjing Med Univ, Affiliated Brain Hosp, Inst Neuropsychiat, Nanjing 210029, Peoples R China.; Zhang, FQ (corresponding author), Nanjing Med Univ, Dept Psychiat, Affiliated Brain Hosp, 264 Guangzhou Rd, Nanjing 210029, Peoples R China.
EM zhangfq@njmu.edu.cn
RI song, yuqing/LCD-2989-2024
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NR 35
TC 0
Z9 0
U1 0
U2 0
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1758-5996
J9 DIABETOL METAB SYNDR
JI Diabetol. Metab. Syndr.
PD FEB 19
PY 2025
VL 17
IS 1
AR 63
DI 10.1186/s13098-025-01630-x
PG 5
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA X6S8C
UT WOS:001426630400002
PM 39972391
OA gold
DA 2025-06-11
ER

PT J
AU Kajantie, E
   Johnson, S
   Heinonen, K
   Anderson, PJ
   Wolke, D
   Evensen, KAI
   Räikkönen, K
   Darlow, BA
   van der Pal, S
   Indredavik, MS
   Jaekel, J
   Hovi, P
   Morrison, K
   Verrips, E
   Doyle, LW
AF Kajantie, Eero
   Johnson, Samantha
   Heinonen, Kati
   Anderson, Peter J.
   Wolke, Dieter
   Evensen, Kari Anne I.
   Raikkonen, Katri
   Darlow, Brian A.
   van der Pal, Sylvia
   Indredavik, Marit S.
   Jaekel, Julia
   Hovi, Petteri
   Morrison, Katherine
   Verrips, Erik
   Doyle, Lex W.
CA APIC Adults Born
TI Common Core Assessments in follow-up studies of adults born
   preterm-Recommendation of the Adults Born Preterm International
   Collaboration
SO PAEDIATRIC AND PERINATAL EPIDEMIOLOGY
LA English
DT Article
DE birthweight; follow-up; preterm; recommendation
ID LOW-BIRTH-WEIGHT; BECK DEPRESSION INVENTORY; SELF-REPORT MEASURES;
   YOUNG-ADULTS; PSYCHOMETRIC PROPERTIES; HEALTH; RETINOPATHY; CHILDREN;
   ANXIETY; PREMATURITY
AB Background Of all newborns, 1%-2% are born very preterm (VP; <32 weeks) or with very low birthweight (VLBW; <= 1500 g). Advances in prenatal and neonatal care have substantially improved their survival, and the first generations who have benefited from these advances are now entering middle age. While most lead healthy lives, on average these adults are characterised by a number of adversities. These include cardiometabolic risk factors, airway obstruction, less physical activity, poorer visual function, lower cognitive performance, and a behavioural phenotype that includes inattention and internalising and socially withdrawn behaviour that may affect life chances and quality of life. Outcomes in later adulthood are largely unknown, and identifying trajectories of risk or resilience is essential in developing targeted interventions. Joint analyses of data and maintenance of follow-up of cohorts entering adulthood are essential. Such analyses are ongoing within the Adults Born Preterm International Collaboration (APIC; ). Joint analyses require data harmonisation, highlighting the importance of consistent assessment methodologies. Objective To present an expert recommendation on Common Core Assessments to be used in follow-up assessments of adults born preterm. Methods Principles of Common Core Assessments were discussed at APIC meetings. Experts for each specific outcome domain wrote the first draft on assessments pertaining to that outcome. These drafts were combined and reviewed by all authors. Consensus was reached by discussion at APIC meetings. Results We present a recommendation by APIC experts on consistent measures to be used in adult follow-up assessments. Conclusions The recommendation encompasses both "core" measures which we recommend to use in all assessments of adults born preterm that include the particular outcome. This will allow comparability between time and location. The recommendation also lists optional measures, focusing on current gaps in knowledge. It includes sections on study design, cardiometabolic and related biomarkers, biological samples, life style, respiratory, ophthalmic, cognitive, mental health, personality, quality of life, sociodemographics, social relationships, and reproduction.
C1 [Kajantie, Eero; Jaekel, Julia; Hovi, Petteri] Finnish Inst Hlth & Welf, Dept Publ Hlth Solut, Helsinki, Finland.
   [Kajantie, Eero; Jaekel, Julia; Hovi, Petteri] Finnish Inst Hlth & Welf, Dept Publ Hlth Solut, Oulu, Finland.
   [Kajantie, Eero] Oulu Univ Hosp, MRC Oulu, PEDEGO Res Unit, Oulu, Finland.
   [Kajantie, Eero] Univ Oulu, Oulu, Finland.
   [Kajantie, Eero; Evensen, Kari Anne I.; Indredavik, Marit S.] Norwegian Univ Sci & Technol, Dept Clin & Mol Med, Trondheim, Norway.
   [Kajantie, Eero; Hovi, Petteri] Helsinki Univ Cent Hosp, Childrens Hosp, Helsinki, Finland.
   [Kajantie, Eero; Hovi, Petteri] Univ Helsinki, Helsinki, Finland.
   [Johnson, Samantha] Univ Leicester, Dept Hlth Sci, Leicester, Leics, England.
   [Heinonen, Kati; Raikkonen, Katri] Univ Helsinki, Dept Psychol & Logoped, Fac Med, Helsinki, Finland.
   [Anderson, Peter J.] Monash Univ, Turner Inst Brain & Mental Hlth, Melbourne, Vic, Australia.
   [Anderson, Peter J.; Doyle, Lex W.] Murdoch Childrens Res Inst, Clin Sci, Melbourne, Vic, Australia.
   [Wolke, Dieter; Jaekel, Julia] Univ Warwick, Dept Psychol, Coventry, W Midlands, England.
   [Wolke, Dieter] Univ Warwick, Warwick Med Sch, Coventry, W Midlands, England.
   [Evensen, Kari Anne I.] Norwegian Univ Sci & Technol, Dept Publ Hlth & Nursing, Trondheim, Norway.
   [Evensen, Kari Anne I.] Oslo Metropolitan Univ, Dept Physiotherapy, Oslo, Norway.
   [Evensen, Kari Anne I.] Trondheim Municipal, Unit Physiotherapy Serv, Trondheim, Norway.
   [Darlow, Brian A.] Univ Otago, Dept Paediat, Christchurch, New Zealand.
   [van der Pal, Sylvia; Verrips, Erik] Netherlands Org Appl Sci Res TNO, Dept Child Hlth, Leiden, Netherlands.
   [Jaekel, Julia] Univ Tennessee Knoxville, Dept Child & Family Studies, Knoxville, TN USA.
   [Hovi, Petteri] Tampere Univ, Dept Pediat, Tampere, Finland.
   [Hovi, Petteri] Tampere Univ Hosp, Tampere, Finland.
   [Morrison, Katherine] McMaster Univ, Ctr Metab Obes & Diabet, Dept Pediat, Hamilton, ON, Canada.
   [Doyle, Lex W.] Univ Melbourne, Royal Womens Hosp, Dept Obstet & Gynaecol, Res Off, Melbourne, Vic, Australia.
   [Doyle, Lex W.] Univ Melbourne, Royal Womens Hosp, Dept Paediat, Res Off, Melbourne, Vic, Australia.
C3 University of Oulu; University of Oulu; Norwegian University of Science
   & Technology (NTNU); University of Helsinki; Helsinki University Central
   Hospital; University of Helsinki; University of Leicester; University of
   Helsinki; Monash University; Murdoch Children's Research Institute;
   University of Warwick; University of Warwick; Norwegian University of
   Science & Technology (NTNU); Oslo Metropolitan University (OsloMet);
   University of Otago; Netherlands Organization Applied Science Research;
   University of Tennessee System; University of Tennessee Knoxville;
   Tampere University; Tampere University; Tampere University Hospital;
   McMaster University; University of Melbourne; The Royal Women's
   Hospital; University of Melbourne; The Royal Women's Hospital
RP Kajantie, E (corresponding author), Finnish Inst Hlth & Welf, Dept Publ Hlth Solut, Helsinki, Finland.
EM eero.kajantie@thl.fi
RI Morrison, Katherine/AAO-8046-2021; Johnson, Samantha/S-6876-2019; Doyle,
   Lex/AAJ-5205-2021; Anderson, Peter/O-5302-2019; Anderson,
   Peter/B-6839-2015; Jaekel, Julia/AAB-5795-2021; Wolke,
   Dieter/C-5372-2008
OI Anderson, Peter/0000-0001-7430-868X; van der Pal,
   Sylvia/0000-0001-9706-9298; Doyle, Lex/0000-0002-7667-7312; Jaekel,
   Julia/0000-0001-6123-3375; Wolke, Dieter/0000-0003-0304-268X; Hovi,
   Petteri/0000-0002-7790-007X; Heinonen, Kati/0000-0002-1262-5599;
   Morrison, Katherine/0000-0002-1737-256X; Johnson,
   Samantha/0000-0001-8963-7881
FU Academy of Finland; Canadian Institutes of Health Research Operating
   grant [MOP - 119386]; Cure Kids NZ; European Commission [733280];
   Foundation for Pediatric Research; National Health & Medical Research
   Council, Australia; Norface DIAL [462-16-040]; Signe and Ane Gyllenberg
   Foundation; Sigrid Juselius Foundation
FX Academy of Finland (to EK, KH, KR, and PH), Canadian Institutes of
   Health Research Operating grant (#MOP - 119386 to KMM), Cure Kids NZ (to
   BAD), European Commission (Horizon 2020 award 733280 RECAP-preterm; to
   EK, DW, EV, KAIE, KH, KR, MSI, PH, SJ, and SvdP), Foundation for
   Pediatric Research (to EK), National Health & Medical Research Council,
   Australia (to PJA and LWD), Norface DIAL (Consortium 462-16-040 Premlife
   to EK, DW, KR), Signe and Ane Gyllenberg Foundation (to EK, KR), and
   Sigrid Juselius Foundation (to EK).
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NR 79
TC 21
Z9 21
U1 2
U2 9
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0269-5022
EI 1365-3016
J9 PAEDIATR PERINAT EP
JI Paediatr. Perinat. Epidemiol.
PD MAY
PY 2021
VL 35
IS 3
BP 371
EP 387
DI 10.1111/ppe.12694
EA SEP 2020
PG 17
WC Public, Environmental & Occupational Health; Obstetrics & Gynecology;
   Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; Obstetrics & Gynecology;
   Pediatrics
GA RO4UP
UT WOS:000573337900001
PM 32990377
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Jung, YE
   Kang, KY
AF Jung, Young-Eun
   Kang, Kwi Young
TI Elevated hs-CRP level is associated with depression in younger adults:
   Results from the Korean National Health and Nutrition Examination Survey
   (KNHANES 2016)
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE C-reactive protein; PHQ-9; Depression; Inflammation; Younger adults
ID C-REACTIVE PROTEIN; CORONARY-HEART-DISEASE; INFLAMMATORY MARKERS;
   METABOLIC SYNDROME; OLDER-ADULTS; SYMPTOMS; POPULATION; CYTOKINES;
   MORTALITY; MOOD
AB Introduction: Reports on the association between the level of circulating high-sensitivity C-reactive protein (hsCRP) and depression have been inconsistent. The aim of this study was to examine the association between hsCRP and depression in a large sample.
   Methods: This study used data obtained from a representative Korean sample of 5447 people who participated in the first (2016) year of the seventh Korean National Health and Nutrition Examination Survey (KNHNES VII-1). Depression was identified using a cutoff of 5 on the Patient Health Questionnaire-9 (PHQ-9), and high hs-CPR level was defined as a 3.0 mg/L.
   Findings: Participants with a high CRP levels had a significantly higher rate of depression than did those with a low hs-CRP levels (25.1% vs. 19.8%, p = 0.007). Serum hs-CRP was independently associated with the PHQ-9 total score after adjusting for potentially confounding factors (B = 0.014; 95% CI = 0.008-0.020). After controlling for body mass index (BMI), smoking, alcohol use problems, hypertension, diabetes, dyslipidemia, chronic illness related hs-CRP, and metabolic syndrome. Furthermore, elevated hs-CRP level was significantly associated with an increased risk of depression (adjusted OR = 1.44; 95% CI = 1.01-2.07) in younger adults, but no significant association was observed among older adults.
   Conclusion: These findings suggest a significant correlation between high hs-CRP levels and depression in younger adults. Further studies are necessary to investigate the age-specific association and the biological mechanism involved.
C1 [Jung, Young-Eun] Jeju Natl Univ, Sch Med, Dept Psychiat, Jeju, South Korea.
   [Kang, Kwi Young] Catholic Univ Korea, Incheon St Marys Hosp, Coll Med, Div Rheumatol,Dept Internal Med, 56 Dongsu Ro, Incheon, South Korea.
C3 Jeju National University; Catholic University of Korea
RP Kang, KY (corresponding author), Catholic Univ Korea, Incheon St Marys Hosp, Coll Med, Div Rheumatol,Dept Internal Med, 56 Dongsu Ro, Incheon, South Korea.
EM kykang@catholic.ac.kr
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NR 69
TC 22
Z9 23
U1 0
U2 10
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD NOV
PY 2019
VL 109
AR 104397
DI 10.1016/j.psyneuen.2019.104397
PG 7
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA JP5VE
UT WOS:000498331200014
PM 31377557
DA 2025-06-11
ER

PT S
AU King, C
   Lanaspa, MA
   Jensen, T
   Tolan, DR
   Sánchez-Lozada, LG
   Johnson, RJ
AF King, Christopher
   Lanaspa, Miguel A.
   Jensen, Thomas
   Tolan, Dean R.
   Gabriela Sanchez-Lozada, L.
   Johnson, Richard J.
BE TrevinoBecerra, A
   Iseki, K
TI Uric Acid as a Cause of the Metabolic Syndrome
SO URIC ACID IN CHRONIC KIDNEY DISEASE
SE Contributions to Nephrology
LA English
DT Article; Book Chapter
ID FATTY LIVER-DISEASE; SUGAR-SWEETENED BEVERAGES; INSULIN-RESISTANCE;
   BLOOD-PRESSURE; OXIDATIVE STRESS; RISK-FACTORS; ASYMPTOMATIC
   HYPERURICEMIA; OVERWEIGHT/OBESE MEN; URATE HYDROPEROXIDE;
   CELL-PROLIFERATION
AB Hyperuricemia is common in subjects with obesity, metabolic syndrome, and type 2 diabetes. For many years, hyperuricemia was attributed to the effects of insulin resistance to reduce urinary excretion of uric acid, and it was believed that uric acid may not have any causal role in the metabolic syndrome. However, in recent years, hyperuricemia has been found to independently predict the development of diabetes. Experimental studies have also shown that hyperuricemia may mediate insulin resistance, fatty liver, and dyslipidemia in both fructose-dependent and fructose-independent models of metabolic syndrome. The mechanism for uric acid-induced insulin resistance appears to be mediated by the development of mitochondrial oxidative stress and impairment of insulin-dependent stimulation of nitric oxide in endothelial cells. Pilot studies in humans have reported a potential benefit of lowering serum uric acid on insulin resistance. Large clinical trials are recommended. If uric acid is shown to be a mediator of incident type 2 diabetes in humans, then lowering serum uric acid would represent a simple and inexpensive way to help prevent the development of diabetes and to slow the epidemic. (c) 2018 S. Karger AG, Basel
C1 [King, Christopher; Lanaspa, Miguel A.; Jensen, Thomas; Johnson, Richard J.] Univ Colorado Denver, Div Renal Dis & Hypertens, Aurora, CO USA.
   [Tolan, Dean R.] Boston Univ, Dept Biol, 5 Cummington St, Boston, MA 02215 USA.
   [Gabriela Sanchez-Lozada, L.] INC Ignacio Chavez, Lab Renal Physiopathol, Mexico City, DF, Mexico.
C3 Children's Hospital Colorado; University of Colorado System; University
   of Colorado Anschutz Medical Campus; Boston University
RP Johnson, RJ (corresponding author), Div Renal Dis & Hypertens, 12700 East 19th Ave, Aurora, CO 80045 USA.
EM Richard.Johnson@ucdenver.edu
RI Lanaspa, Miguel/AAO-4971-2020; Sanchez-Lozada, Laura/AAS-2104-2021
OI Sanchez-Lozada, Laura-Gabriela/0000-0003-0348-9617
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NR 115
TC 131
Z9 144
U1 2
U2 26
PU KARGER
PI BASEL
PA POSTFACH, CH-4009 BASEL, SWITZERLAND
SN 0302-5144
EI 1662-2782
BN 978-3-318-06251-9; 978-3-318-06250-2
J9 CONTRIB NEPHROL
JI Contrib.Nephrol.
PY 2018
VL 192
BP 88
EP 102
DI 10.1159/000484283
D2 10.1159/isbn.978-3-318-06251-9
PG 15
WC Urology & Nephrology
WE Book Citation Index – Science (BKCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA BK3ON
UT WOS:000435332200014
PM 29393133
DA 2025-06-11
ER

PT J
AU Janak, JC
   Pérez, A
   Alamgir, H
   Orman, JA
   Cooper, SP
   Shuval, K
   DeFina, L
   Barlow, CE
   Gabriel, KP
AF Janak, Jud C.
   Perez, Adriana
   Alamgir, Hasanat
   Orman, Jean A.
   Cooper, Sahron P.
   Shuval, Kerem
   DeFina, Laura
   Barlow, Carolyn E.
   Gabriel, Kelley Pettee
TI US military service and the prevalence of metabolic syndrome: Findings
   from a cross-sectional analysis of the Cooper Center Longitudinal Study,
   1979-2013
SO PREVENTIVE MEDICINE
LA English
DT Article
ID POSTTRAUMATIC-STRESS-DISORDER; OF-VETERANS-AFFAIRS; ALL-CAUSE MORTALITY;
   PHYSICAL-ACTIVITY; CARDIORESPIRATORY FITNESS; CARDIOVASCULAR-DISEASE;
   TOBACCO PROMOTION; CIGARETTE-SMOKING; NATIONAL-HEALTH; LIFE-COURSE
AB U.S. military service confers both health benefits and risks potentially associated with a clustering of cardiovascular risk factors called metabolic syndrome. However, the association between prior military service and metabolic syndrome has not sufficiently been examined. The purpose of the study was to compare the prevalence of metabolic syndrome by prior military service status. Among 42,370 men (887 with prior military service) examined from 1979 to 2013 at the Cooper Clinic (Dallas, TX), we used a cross-sectional study design to examine the association between military service and metabolic syndrome. First, an unadjusted log binomial regression model was performed by regressing the prevalence of metabolic syndrome on prior service. This was followed by performing Kleinbaum's modeling strategy for assessing confounding. The same methodology was used to explore the association between individual metabolic syndrome risk factors and prior service. Prior military service was not significantly associated with the prevalence of metabolic syndrome (PR= 0.98, 0.89-1.07). None of the variables explored were identified as confounders. Participants with prior military service had lower prevalence of both elevated levels of triglycerides (PR= 0.89, 0.80-0.99) and low levels of high-density lipoprotein-cholesterol (PR= 0.78, 0.70-0.88). They had a higher prevalence of elevated resting systolic blood pressure (PR= 1.23, 1.12-1.35). However, none of these associations were significant after adjusting for identified confounders: age; cardiorespiratory fitness; and exam year. Study findings indicate that military service was not independently associated with the prevalence of metabolic syndrome or its components. Future research is warranted longitudinally assessing the impact of military service on long-term outcomes. (C) 2016 Elsevier Inc. All rights reserved.
C1 [Janak, Jud C.] US Army, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
   [Perez, Adriana; Gabriel, Kelley Pettee] Univ Texas Hlth Sci Ctr, Austin, TX 78727 USA.
   [Alamgir, Hasanat; Cooper, Sahron P.] New York Med Coll, Valhalla, NY 10595 USA.
   [Orman, Jean A.] US Army, Inst Surg Res, Joint Trauma Syst, Ft Sam Houston, TX 78234 USA.
   [Cooper, Sahron P.] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78212 USA.
   [Shuval, Kerem; DeFina, Laura; Barlow, Carolyn E.] Amer Canc Soc, Atlanta, GA 30302 USA.
   [Shuval, Kerem; DeFina, Laura; Barlow, Carolyn E.] Cooper Inst, Richardson, TX 75080 USA.
C3 New York Medical College; University of Texas System; University of
   Texas Health Science Center at San Antonio; American Cancer Society;
   Cooper Institute
RP Janak, JC (corresponding author), US Army, Inst Surg Res, Ft Sam Houston, TX 78234 USA.
EM judson.c.janak.ctr@mail.mil
RI wright, beth/V-7496-2019; Alamgir, Hasanat/U-9354-2019
OI Perez, Adriana/0000-0002-6859-9916
FU Dell Center for Healthy Living; National Institute of Occupational and
   Environmental Health/Centers for Disease Control and Prevention
   [5T42OH008421]
FX Support and funding for this study was provided by both the Dell Center
   for Healthy Living and Grant No. 5T42OH008421 from the National
   Institute of Occupational and Environmental Health/Centers for Disease
   Control and Prevention to the Southwest Center for Occupational and
   Environmental Health. Lastly, we thank Dr. Kenneth H. Cooper of the
   Cooper Clinic for establishing the CCLS, the Cooper Clinic physicians
   and technicians for data collection, and the Cooper Institute staff for
   data management. The authors report no conflicts of interest.
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TC 8
Z9 8
U1 0
U2 8
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0091-7435
EI 1096-0260
J9 PREV MED
JI Prev. Med.
PD FEB
PY 2017
VL 95
IS 1
BP 52
EP 58
DI 10.1016/j.ypmed.2016.11.017
PG 7
WC Public, Environmental & Occupational Health; Medicine, General &
   Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; General & Internal Medicine
GA EP3SY
UT WOS:000397303200007
PM 27939969
DA 2025-06-11
ER

PT J
AU Kumar, SA
   Sharma, SD
   Katyal, RV
   Ahmed, CYG
AF Kumar, Senthil Arun
   Sharma, Surabhi Dinesh
   Katyal, R. Vaani
   Ahmed, Chaudhary Yasmeen Gulzar
TI Polyphenols from Edible Brown Seaweeds Against Adiposopathy-Associated
   Metabolic Ailments
SO FOOD REVIEWS INTERNATIONAL
LA English
DT Review; Early Access
DE Adiposopathy; adipocyte hypertrophy; brown algae; inflammation;
   metabolic syndrome; polyphenols; visceral fat
ID ALGA ECKLONIA-CAVA; HIGH-FAT DIET; EPICARDIAL ADIPOSE-TISSUE; ENZYME ACE
   INHIBITION; SICK FAT; NITRIC-OXIDE; ALPHA-GLUCOSIDASE; OXIDATIVE STRESS;
   DOUBLE-BLIND; IN-VITRO
AB Adiposopathy principally characterized by adipocyte hypertrophy in visceral fat pads with excess triglyceride accumulation augments the sickening of adipocyte tissue cells. Adipocyte sickening is the central precursor of chronic-low grade/systemic inflammation and impaired lipid profile in metabolically sick obese patients over metabolically healthy obese subjects. With these pathophysiology alterations, obese patients are susceptible to metabolic syndrome associated with hyperglycemia, insulin resistance, dyslipidemia, hypertension, coronary artery atherosclerosis, endothelial dysfunction, cardiac failure, and liver steatosis. Brown seaweeds enriched in all essential nutrients, especially polyphenols, have been widely consumed as a staple diet. In-vitro and in-vivo studies showed polyphenols derived from brown seaweeds could reverse metabolic impairments via attenuating hyperglycemia, inflammation, systolic blood pressure, oxidative stress, and insulin resistance. However, human clinical trials remain inadequate to witness the therapeutic potential of brown algal polyphenols against metabolic syndrome, especially adiposopathy-linked metabolic syndrome. The article unveils the therapeutic efficacy of brown algal polyphenols in crude or purified formulations with their effective human therapeutic-dose concentrations 2838 mg/day (crude)/85-177 mg/day (pure fractions) to attenuate adiposopathy-linked metabolic ailments in metabolically unhealthy obese patients.
C1 [Kumar, Senthil Arun; Sharma, Surabhi Dinesh; Katyal, R. Vaani] Parul Univ, Parul Inst Technol, Dept Biotechnol, Vadodara, India.
   [Ahmed, Chaudhary Yasmeen Gulzar] Dr LH Hiranandani Hosp, Dietet Dept, Mumbai, India.
C3 Parul University
RP Kumar, SA (corresponding author), Parul Inst Technol, Dept Biotechnol, PO Limda, Ta Waghodia 391760, Gujarat, India.
EM drsakbiomed1727@outlook.com
OI Kumar, Senthil Arun/0000-0001-6167-6694
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TC 0
Z9 0
U1 9
U2 9
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 8755-9129
EI 1525-6103
J9 FOOD REV INT
JI Food Rev. Int.
PD 2025 JAN 18
PY 2025
DI 10.1080/87559129.2025.2451097
EA JAN 2025
PG 28
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA S5N9I
UT WOS:001398696600001
DA 2025-06-11
ER

PT J
AU Hassamal, S
AF Hassamal, Sameer
TI Chronic stress, neuroinflammation, and depression: an overview of
   pathophysiological mechanisms and emerging anti-inflammatories
SO FRONTIERS IN PSYCHIATRY
LA English
DT Review
DE depression; stress neuroinflammation; cortisol; HPA axis;
   neuroplasticity Glutamate; GABA
ID COGNITIVE-BEHAVIORAL THERAPY; TOLL-LIKE RECEPTORS; DOUBLE-BLIND;
   TRANSLOCATOR PROTEIN; METABOLIC SYNDROME; SYMPTOM SEVERITY;
   SERUM-LEVELS; BRAIN; INFLAMMATION; ANTIDEPRESSANT
AB In a subset of patients, chronic exposure to stress is an etiological risk factor for neuroinflammation and depression. Neuroinflammation affects up to 27% of patients with MDD and is associated with a more severe, chronic, and treatment-resistant trajectory. Inflammation is not unique to depression and has transdiagnostic effects suggesting a shared etiological risk factor underlying psychopathologies and metabolic disorders. Research supports an association but not necessarily a causation with depression. Putative mechanisms link chronic stress to dysregulation of the HPA axis and immune cell glucocorticoid resistance resulting in hyperactivation of the peripheral immune system. The chronic extracellular release of DAMPs and immune cell DAMP-PRR signaling creates a feed forward loop that accelerates peripheral and central inflammation. Higher plasma levels of inflammatory cytokines, most consistently interleukin IL-1 beta, IL-6, and TNF-alpha, are correlated with greater depressive symptomatology. Cytokines sensitize the HPA axis, disrupt the negative feedback loop, and further propagate inflammatory reactions. Peripheral inflammation exacerbates central inflammation (neuroinflammation) through several mechanisms including disruption of the blood-brain barrier, immune cellular trafficking, and activation of glial cells. Activated glial cells release cytokines, chemokines, and reactive oxygen and nitrogen species into the extra-synaptic space dysregulating neurotransmitter systems, imbalancing the excitatory to inhibitory ratio, and disrupting neural circuitry plasticity and adaptation. In particular, microglial activation and toxicity plays a central role in the pathophysiology of neuroinflammation. Magnetic resonance imaging (MRI) studies most consistently show reduced hippocampal volumes. Neural circuitry dysfunction such as hypoactivation between the ventral striatum and the ventromedial prefrontal cortex underlies the melancholic phenotype of depression. Chronic administration of monoamine-based antidepressants counters the inflammatory response, but with a delayed therapeutic onset. Therapeutics targeting cell mediated immunity, generalized and specific inflammatory signaling pathways, and nitro-oxidative stress have enormous potential to advance the treatment landscape. Future clinical trials will need to include immune system perturbations as biomarker outcome measures to facilitate novel antidepressant development. In this overview, we explore the inflammatory correlates of depression and elucidate pathomechanisms to facilitate the development of novel biomarkers and therapeutics.
C1 [Hassamal, Sameer] Calif Univ Sci & Med, Colton, CA 92324 USA.
   [Hassamal, Sameer] Clinicaltriallink, Los Angeles, CA 90502 USA.
   [Hassamal, Sameer] Calif Neuropsychiat Inst, Ontario, CA 92868 USA.
RP Hassamal, S (corresponding author), Calif Univ Sci & Med, Colton, CA 92324 USA.; Hassamal, S (corresponding author), Clinicaltriallink, Los Angeles, CA 90502 USA.; Hassamal, S (corresponding author), Calif Neuropsychiat Inst, Ontario, CA 92868 USA.
EM shassama@gmail.com
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NR 187
TC 162
Z9 171
U1 62
U2 167
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-0640
J9 FRONT PSYCHIATRY
JI Front. Psychiatry
PD MAY 11
PY 2023
VL 14
AR 1130989
DI 10.3389/fpsyt.2023.1130989
PG 18
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA H3EP5
UT WOS:000994834800001
PM 37252156
OA Green Published, gold
HC Y
HP Y
DA 2025-06-11
ER

PT J
AU Krijt, J
   Sokolová, J
   Silhavy, J
   Mlejnek, P
   Kubovciak, J
   Liska, F
   Malínská, H
   Hüttl, M
   Marková, I
   Krizková, M
   Stipanuk, MH
   Krízek, T
   Ditroi, T
   Nagy, P
   Kozich, V
   Pravenec, M
AF Krijt, Jakub
   Sokolova, Jitka
   Silhavy, Jan
   Mlejnek, Petr
   Kubovciak, Jan
   Liska, Frantisek
   Malinska, Hana
   Huettl, Martina
   Markova, Irena
   Krizkova, Michaela
   Stipanuk, Martha H.
   Krizek, Tomas
   Ditroi, Tamas
   Nagy, Peter
   Kozich, Viktor
   Pravenec, Michal
TI High Cysteine Diet Reduces Insulin Resistance in SHR-CRP Rats
SO PHYSIOLOGICAL RESEARCH
LA English
DT Article
DE SHR-CRP rats; Metabolic syndrome; Taurine; Cysteine; Insulin resistance;
   Cysteine dioxygenase
ID CONTAINING AMINO-ACIDS; OXIDATIVE STRESS; TAURINE; METABOLISM; SULFUR;
   HOMOCYSTEINE; DIOXYGENASE; GLUCOSE; PLASMA; LEVEL
AB Increased plasma total cysteine (tCys) has been associated with obesity and metabolic syndrome in human and some animal studies but the underlying mechanisms remain unclear. In this study, we aimed at evaluating the effects of high cysteine diet administered to SHR-CRP transgenic rats, a model of metabolic syndrome and inflammation. SHR-CRP rats were fed either standard (3.2 g cystine/kg diet) or high cysteine diet (HCD, enriched with additional 4 g L-cysteine/kg diet). After 4 weeks, urine, plasma and tissue samples were collected and parameters of metabolic syndrome, sulfur metabolites and hepatic gene expression were evaluated. Rats on HCD exhibited similar body weights and weights of fat depots, reduced levels of serum insulin, and reduced oxidative stress in the liver. The HCD did not change concentrations of tCys in tissues and body fluids while taurine in tissues and body fluids, and urinary sulfate were significantly increased. In contrast, betaine levels were significantly reduced possibly compensating for taurine elevation. In summary, increased Cys intake did not induce obesity while it ameliorated insulin resistance in the SHR-CRP rats, possibly due to beneficial effects of accumulating taurine.
C1 [Krijt, Jakub; Sokolova, Jitka; Krizkova, Michaela; Kozich, Viktor] Charles Univ Prague, Dept Pediat & Inherited Metab Disorders, Fac Med 1, Ke Karlovu 2, Prague 212808 2, Czech Republic.
   [Krijt, Jakub; Sokolova, Jitka; Krizkova, Michaela; Kozich, Viktor] Gen Univ Hosp Prague, Ke Karlovu 2, Prague 212808 2, Czech Republic.
   [Silhavy, Jan; Mlejnek, Petr; Liska, Frantisek; Pravenec, Michal] Czech Acad Sci, Lab Genet Model Dis, Inst Physiol, Videnska 1083, Prague 14220 4, Czech Republic.
   [Kubovciak, Jan] Czech Acad Sci, Lab Genom & Bioinformat, Inst Mol Genet, Prague, Czech Republic.
   [Liska, Frantisek; Pravenec, Michal] Charles Univ Prague, Fac Med 1, Inst Biol & Med Genet, Prague, Czech Republic.
   [Liska, Frantisek; Pravenec, Michal] Gen Univ Hosp, Prague, Czech Republic.
   [Malinska, Hana; Huettl, Martina; Markova, Irena] Inst Clin & Expt Med, Ctr Expt Med, Prague, Czech Republic.
   [Stipanuk, Martha H.] Cornell Univ, Div Nutr Sci, Ithaca, NY 14853 USA.
   [Krizek, Tomas] Charles Univ Prague, Fac Sci, Dept Analyt Chem, Prague, Czech Republic.
   [Ditroi, Tamas; Nagy, Peter] Natl Inst Oncol, Dept Mol Immunol & Toxicol, Budapest, Hungary.
   [Nagy, Peter] Univ Vet Med, Dept Anat & Histol, Budapest, Hungary.
C3 Charles University Prague; General University Hospital Prague; Czech
   Academy of Sciences; Institute of Physiology of the Czech Academy of
   Sciences; Czech Academy of Sciences; Institute of Molecular Genetics of
   the Czech Academy of Sciences; Charles University Prague; General
   University Hospital Prague; Institute for Clinical & Experimental
   Medicine (IKEM); Cornell University; Charles University Prague; National
   Institute of Oncology Hungary; University of Veterinary Medicine
   Budapest
RP Kozich, V (corresponding author), Charles Univ Prague, Dept Pediat & Inherited Metab Disorders, Fac Med 1, Ke Karlovu 2, Prague 212808 2, Czech Republic.; Kozich, V (corresponding author), Gen Univ Hosp Prague, Ke Karlovu 2, Prague 212808 2, Czech Republic.; Pravenec, M (corresponding author), Czech Acad Sci, Lab Genet Model Dis, Inst Physiol, Videnska 1083, Prague 14220 4, Czech Republic.
EM viktor.kozich@vfn.cz; michal.pravenec@fgu.cas.cz
RI Kubovčiak, Jan/AAH-5473-2021; Krizkova, Michaela/AAM-2020-2021; Silhavy,
   Jan/B-5292-2014; Liska, Frantisek/N-9192-2017; Krizek,
   Tomas/L-8349-2017; Pravenec, Michal/B-1666-2012; Mlejnek,
   Petr/C-2305-2012; Kozich, Viktor/A-7672-2008; Sokolova,
   Jitka/H-9924-2015; Krijt, Jakub/F-4861-2017
OI Pravenec, Michal/0000-0001-9197-5871; Mlejnek, Petr/0000-0002-4218-8983;
   Kozich, Viktor/0000-0001-5820-5277; Markova, Irena/0000-0002-4331-7636;
   Sokolova, Jitka/0000-0002-0453-3336; Krijt, Jakub/0000-0002-1738-654X
FU Czech Health Research Council [16-30384A]; Ministry of Health of the
   Czech Republic under the conceptual development of research
   organizations programs [IN 00023001, VFN 64165]; ELIXIR CZ research
   infrastructure project (MEYS Grant) [LM2018131]; Institute of Molecular
   Genetics [CAS - RVO: 68378050]; National Laboratories Excellence program
   (under the National Tumorbiology Laboratory project)
FX This work was supported by the grant from the Czech Health Research
   Council Nr. 16-30384A and by the Ministry of Health of the Czech
   Republic under the conceptual development of research organizations
   programs (Institute for Clinical and Experimental Medicine - IKEM, IN
   00023001; General University Hospital in Prague-RVO VFN 64165) . This
   work was also supported by ELIXIR CZ research infrastructure project
   (MEYS Grant No: LM2018131) including access to computing and storage
   facilities and by institutional support of the Institute of Molecular
   Genetics CAS - RVO: 68378050. P. N. acknowledges financial support from
   the National Laboratories Excellence program (under the National
   Tumorbiology Laboratory project) . The authors would like to thank Olena
   Oliyarnyk for oxidative stress analysis.
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NR 35
TC 5
Z9 6
U1 1
U2 16
PU ACAD SCIENCES CZECH REPUBLIC, INST PHYSIOLOGY
PI PRAGUE 4
PA VIDENSKA 1083, PRAGUE 4 142 20, CZECH REPUBLIC
SN 0862-8408
EI 1802-9973
J9 PHYSIOL RES
JI Physiol. Res.
PD OCT
PY 2021
VL 70
IS 5
BP 687
EP +
DI 10.33549/physiolres.934736
PG 17
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA XN9IF
UT WOS:000729810300003
PM 34505526
OA gold, Green Published
DA 2025-06-11
ER

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   Narender, T.
   Gaikwad, Anil Nilkanth
TI Ecliptal, a promising natural lead isolated from Eclipta alba
   modulates adipocyte function and ameliorates metabolic syndrome
SO TOXICOLOGY AND APPLIED PHARMACOLOGY
LA English
DT Article
DE 3T3-L1 adipocyte; Anti-adipogenic; Dyslipidemia; Insulin sensitivity
ID MITOTIC CLONAL EXPANSION; WNT/BETA-CATENIN PATHWAY; INHIBITS
   ADIPOGENESIS; INSULIN SENSITIVITY; IN-VIVO; RESISTANCE; EXTRACT;
   OBESITY; STRESS; RATS
AB A swift increase has been observed in the number of individuals with metabolic syndrome worldwide. A number of natural compounds have been identified towards combating metabolic syndrome. Adding to this premise, here we report the pleiotropic activities of Ecliptal (EC); a natural compound isolated from the herb Eclipta alba. Administration of EC was shown to have prominent anti-adipogenic effects in 3T3-L1 and hMSC derived adi-pocytes. It was shown to activate Wnt-pathway and alter AKT signaling. Additionally, it caused cell cycle arrest and inhibited mitotic clonal expansion. EC treatment augmented mitochondrial biogenesis as well as function as estimated by expression of PGC1 alpha, UCP-1, mitochondrial complexes and estimation of oxygen consumption rate. EC also reduced LPS-induced inflammation and tunicamycin induced ER stress. Further, EC enhanced insulin sensitivity by increasing AKT phosphorylation, inhibiting PKC alpha/beta II phosphorylation and reducing leptin/adi-ponectin ratio. Finally, EC administration in Syrian golden hamsters was shown to have potent anti-dyslipidemic effects. Cumulatively, encompassing pleiotropic activities of EC, it could prove to be a potential drug candidate against obesity, insulin resistance and related metabolic syndrome.
C1 [Gupta, Abhishek; Kumar, Durgesh; Shankar, Kripa; Varshney, Sabi.; Rajan, Sujith; Srivastava, Ankita; Gupta, Sanchita; Gaikwad, Anil Nilkanth] CSIR, Cent Drug Res Inst, Div Pharmacol, Lucknow 226031, Uttar Pradesh, India.
   [Kumar, Ashok; Singh, Rohit; Narender, T.] CSIR, Cent Drug Res Inst, Div Med & Proc Chem, Lucknow 226031, Uttar Pradesh, India.
   [Kumar, Durgesh; Singh, Rohit; Varshney, Sabi.; Rajan, Sujith; Srivastava, Ankita; Gupta, Sanchita] Acad Sci & Innovat Res, New Delhi 110025, India.
C3 Council of Scientific & Industrial Research (CSIR) - India; CSIR -
   Central Drug Research Institute (CDRI); Council of Scientific &
   Industrial Research (CSIR) - India; CSIR - Central Drug Research
   Institute (CDRI); Academy of Scientific & Innovative Research (AcSIR)
RP Gaikwad, AN (corresponding author), CSIR, Cent Drug Res Inst, Div Pharmacol, Lucknow 226031, Uttar Pradesh, India.; Narender, T (corresponding author), CSIR, Cent Drug Res Inst, Div Med & Proc Chem, Lucknow 226031, Uttar Pradesh, India.
EM t_narendra@cdri.res.in; anil_gaikwad@cdri.res.in
RI GUPTA, ABHISHEK/AAE-5897-2021; SHANKAR, KRIPA/ABD-9554-2021; Varshney,
   Salil/JBI-8723-2023; Rajan, Sujith/AAM-1951-2021; Shankar,
   Kripa/G-1220-2018
OI rajan, sujith/0000-0002-8376-0587; Varshney, Salil/0000-0002-5185-3113;
   Singh, Dr. Rohit/0000-0001-8542-6534; Gupta,
   Abhishek/0000-0002-3932-2512; Kumar, Durgesh/0009-0001-7413-3987;
   Shankar, Kripa/0000-0003-3569-9731; KOTA, PRABHAKAR/0000-0002-7537-8433
FU CSIR-CDRI Network project: Towards holistic understanding of complex
   diseases: Unraveling the threads of complex disease (THUNDER) Project
   [BSC0102]; SRF-UGC, New Delhi; UGC-JRF, New Delhi; SRF-CSIR, New Delhi;
   SRF-ICMR, New Delhi; JRF-DBT, Pune
FX The work was supported by CSIR-CDRI Network project: Towards holistic
   understanding of complex diseases: Unraveling the threads of complex
   disease (THUNDER) Project No: BSC0102. AG, KS, SR are supported by
   SRF-UGC, New Delhi, AK is supported by UGC-JRF, New Delhi, DK, RS and AS
   are supported by SRF-CSIR, New Delhi, SV is supported by SRF-ICMR, New
   Delhi, SG is supported by JRF-DBT, Pune.
CR Arias N, 2014, GENES NUTR, V9, DOI 10.1007/s12263-013-0361-7
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NR 34
TC 9
Z9 9
U1 0
U2 5
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0041-008X
EI 1096-0333
J9 TOXICOL APPL PHARM
JI Toxicol. Appl. Pharmacol.
PD JAN 1
PY 2018
VL 338
BP 134
EP 147
DI 10.1016/j.taap.2017.11.016
PG 14
WC Pharmacology & Pharmacy; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Toxicology
GA FT1KI
UT WOS:000422894200014
PM 29175456
DA 2025-06-11
ER

PT J
AU Zass, LJ
   Hart, SA
   Seedat, S
   Hemmings, SMJ
   Malan-Müller, S
AF Zass, Lyndon J.
   Hart, Stephanie A.
   Seedat, Soraya
   Hemmings, Sian M. J.
   Malan-Muller, Stefanie
TI Neuroinflammatory genes associated with post-traumatic stress disorder:
   implications for comorbidity
SO PSYCHIATRIC GENETICS
LA English
DT Review
DE comorbidity; C-reactive protein; cytokines; gene expression;
   glucocorticoid receptor; inflammation; neuroinflammation; nuclear
   factor-kappa beta; post-traumatic stress disorder; single-nucleotide
   polymorphisms
ID C-REACTIVE PROTEIN; GLUCOCORTICOID-RECEPTOR GENE; NECROSIS-FACTOR-ALPHA;
   LOW-GRADE INFLAMMATION; MAJOR DEPRESSIVE DISORDER; METABOLIC SYNDROME;
   ALZHEIMERS-DISEASE; TNF-ALPHA; PARKINSONS-DISEASE; BIPOLAR DISORDER
AB Post-traumatic stress disorder (PTSD) is a debilitating condition that only occurs in the aftermath of traumatic event exposure and is characterized by an impaired stress response and chronic, low-grade inflammation. Dysregulation of the immune system may contribute towards central nervous system tissue damage and exacerbation of fear memories following trauma. Patients with PTSD often have comorbid psychiatric and somatic disorders that are of themselves associated with heightened inflammation. Several immune-related genes have been associated with PTSD and other co-occurring disorders. In this review, we propose that chronic inflammation, particularly neuroinflammation, is an important contributory factor towards PTSD comorbidity. Thus, novel treatments that target dysregulated inflammatory processes could provide symptomatic relief from PTSD and its comorbid disorders. This review investigates the intricate links between chronic stress, anxiety and neuroinflammation and the potential impact of increased neuroinflammation on PTSD pathology and comorbidity. Copyright (C) 2017 Wolters Kluwer Health, Inc. All rights reserved.
C1 [Zass, Lyndon J.; Hart, Stephanie A.] Univ Stellenbosch, DST NRF Ctr Excellence Biomed TB Res, Div Mol Biol & Human Genet, Dept Mol Biol & Human Genet,SA MRC Ctr TB Res, Cape Town, South Africa.
   [Zass, Lyndon J.; Seedat, Soraya; Hemmings, Sian M. J.; Malan-Muller, Stefanie] Univ Stellenbosch, Dept Psychiat, Fac Med & Hlth Sci, ZA-7505 Cape Town, South Africa.
C3 National Research Foundation - South Africa; Stellenbosch University;
   Stellenbosch University
RP Malan-Müller, S (corresponding author), Univ Stellenbosch, Dept Psychiat, Fac Med & Hlth Sci, ZA-7505 Cape Town, South Africa.
RI Siabani, Soraya/U-7739-2017; Hemmings, Sian/ABF-9676-2022
OI Malan-Muller, Stefanie/0000-0003-0639-0129; Seedat,
   Soraya/0000-0002-5118-786X; Zass, Lyndon/0000-0001-8862-1706; Hemmings,
   Sian/0000-0001-8461-1017
FU South African Research Chairs Initiative in PTSD - Department of Science
   and Technology; National Research Foundation; Harry Crossley Foundation
FX This work is supported by the South African Research Chairs Initiative
   in PTSD funded by the Department of Science and Technology and the
   National Research Foundation and Harry Crossley Foundation funding.
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NR 221
TC 34
Z9 38
U1 0
U2 32
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0955-8829
EI 1473-5873
J9 PSYCHIAT GENET
JI Psychiatr. Genet.
PD FEB
PY 2017
VL 27
IS 1
BP 1
EP 16
DI 10.1097/YPG.0000000000000143
PG 16
WC Genetics & Heredity; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Genetics & Heredity; Neurosciences & Neurology
GA EI2OS
UT WOS:000392327700001
PM 27635478
DA 2025-06-11
ER

PT J
AU Gyawali, P
   Richards, RS
   Hughes, DL
   Tinley, P
AF Gyawali, Prajwal
   Richards, Ross S.
   Hughes, Diane L.
   Tinley, Paul
TI Erythrocyte aggregation and metabolic syndrome
SO CLINICAL HEMORHEOLOGY AND MICROCIRCULATION
LA English
DT Article
DE Aggregation; hemorheology; diabetes; obesity; dyslipidemia; hypertension
ID BLOOD-CELL AGGREGATION; HIGH-DENSITY-LIPOPROTEIN; ARTERIAL-HYPERTENSION;
   OXIDATIVE STRESS; MEMBRANE-FLUIDITY; RHEOLOGICAL PROPERTIES;
   DIABETES-MELLITUS; PLASMA VISCOSITY; HEMORHEOLOGICAL ABNORMALITIES;
   CHOLESTEROL EXCHANGE
AB Erythrocyte aggregation has been consistently associated with insulin resistance, central obesity and hypertension in the literature. Oxidative stress and chronic inflammation are almost always present in metabolic syndrome (MetS). Prooxidants and adipocytokines generated in MetS alter erythrocyte morphology, decrease erythrocyte deformability and increase whole blood viscosity (WBV). Increased WBV has been attributed to erythrocyte aggregation which in turn is greatly influenced by other rheological parameters, including its membrane surface charge and plasma fibrinogen concentration. The interplay of hemorheological factors, oxidative stress and inflammation has a detrimental effect in MetS due to the gross disturbance in microcirculation. The hemodynamic aspect of MetS needs further research and exploration.
C1 [Gyawali, Prajwal; Richards, Ross S.; Tinley, Paul] Charles Sturt Univ, Sch Community Hlth, Bathurst, NSW 2795, Australia.
   [Hughes, Diane L.] La Trobe Univ, La Trobe Rural Hlth Sch, Bundoora, Vic 3086, Australia.
C3 Charles Sturt University; La Trobe University
RP Gyawali, P (corresponding author), Charles Sturt Univ, Sch Community Hlth, Bathurst, NSW 2795, Australia.
EM clbioprajwal@gmail.com
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TC 33
Z9 34
U1 1
U2 14
PU IOS PRESS
PI AMSTERDAM
PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS
SN 1386-0291
EI 1875-8622
J9 CLIN HEMORHEOL MICRO
JI Clin. Hemorheol. Microcirc.
PY 2014
VL 57
IS 1
BP 73
EP 83
DI 10.3233/CH-131792
PG 11
WC Hematology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Hematology; Cardiovascular System & Cardiology
GA AJ7XI
UT WOS:000337913900007
PM 24192695
DA 2025-06-11
ER

PT J
AU Brown, R
   Ware, L
   Tey, SL
AF Brown, Rachel
   Ware, Lara
   Tey, Siew Ling
TI Effects of Hazelnut Consumption on Cardiometabolic Risk Factors and
   Acceptance: A Systematic Review
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Article
DE hazelnuts; blood lipids and lipoproteins; apolipoproteins; body weight
   and composition; blood pressure; glycaemia; oxidative stress;
   inflammation; endothelial function; acceptance
ID DENSE SNACK FOODS; NUT CONSUMPTION; CARDIOVASCULAR-DISEASE; POSTPRANDIAL
   GLYCEMIA; INFLAMMATORY MARKERS; ENDOTHELIAL FUNCTION; REGULAR
   CONSUMPTION; WALNUT CONSUMPTION; PHENOLIC PROFILES; BODY-COMPOSITION
AB Despite being rich sources of monounsaturated fat and a number of vitamins, minerals, and phytonutrients, hazelnuts have received less attention than some other nut types. A qualitative systematic review was carried out to determine the effects of hazelnut consumption on acceptance and markers of cardiometabolic health, including blood lipids and lipoproteins, apolipoproteins A1 and B100, body weight and composition, blood pressure, glycemia, antioxidant status, oxidative stress, inflammation, and endothelial function. In total, 22 intervention studies (25 publications) met our inclusion criteria. The findings indicate some improvements in cardiometabolic risk factors; however, limitations in study design mean interpretation is problematic. The inclusion of hazelnuts in the diet did not adversely affect body weight and composition. Acceptance of hazelnuts remained stable over time confirming nut consumption guidelines are feasible and sustainable. Future studies using more robust study designs in a variety of populations are required to draw more definitive conclusions on the health benefits of hazelnut consumption.
C1 [Brown, Rachel; Ware, Lara; Tey, Siew Ling] Univ Otago, Dept Human Nutr, Dunedin 9054, New Zealand.
C3 University of Otago
RP Tey, SL (corresponding author), Univ Otago, Dept Human Nutr, Dunedin 9054, New Zealand.
EM rachel.brown@otago.ac.nz; lara.ware@otago.ac.nz;
   siewling.tey@otago.ac.nz
RI Tey, Siew/AAV-8115-2021
OI Brown, Rachel/0000-0001-6951-7073; Tey, Siew Ling/0000-0002-5064-5283
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NR 82
TC 13
Z9 13
U1 1
U2 14
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD MAR
PY 2022
VL 19
IS 5
AR 2880
DI 10.3390/ijerph19052880
PG 50
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA ZT4CT
UT WOS:000769106800001
PM 35270573
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Baumert, J
   Lukaschek, K
   Kruse, J
   Emeny, RT
   Koenig, W
   von Känel, R
   Ladwig, KH
AF Baumert, Jens
   Lukaschek, Karoline
   Kruse, Johannes
   Emeny, Rebecca Thwing
   Koenig, Wolfgang
   von Kaenel, Roland
   Ladwig, Karl-Heinz
CA KORA Investigators
TI No evidence for an association of posttraumatic stress disorder with
   circulating levels of CRP and IL-18 in a population-based study.
SO CYTOKINE
LA English
DT Article
DE Posttraumatic stress disorder (PTSD); Inflammation; Atherosclerosis;
   C-reactive protein (CRP); Interleukin-18 (IL-18)
ID C-REACTIVE PROTEIN; CORONARY-HEART-DISEASE; LIFETIME TRAUMATIC
   EXPERIENCES; MYOCARDIAL-INFARCTION; PSYCHOLOGICAL STRESS; INFLAMMATORY
   MARKERS; MONICA/KORA AUGSBURG; ELEVATED LEVELS; INTERLEUKIN-18; RISK
AB Several studies have shown associations of posttraumatic stress disorder (PTSD) with the development of cardiometabolic diseases. The underlying psychopathological mechanisms, including potential links to inflammatory processes, have been discussed but remain elusive. Therefore, the aim of the present study was to evaluate the association of PTSD symptoms with the inflammatory biomarkers C-reactive protein (CRP) and interleukin-18 (IL-18). The study population consisted of 3012 participants aged 32-81 years drawn from the population-based KORA F4 study conducted in 2006-08 in the Augsburg region (Southern Germany). PTSD symptoms were measured by the Impact of Event Scale, the Posttraumatic Diagnostic Scale and interview data and classified as no, partial or full PTSD. The associations of PTSD with CRP and IL-18 concentrations were estimated by multiple regression analyses with adjustments for age, sex and cardiometabolic risk factors. Linear regression analyses showed no significant association between PTSD and CRP or IL-18 concentration: adjusted for age and sex, the geometric mean concentrations in participants with full PTSD was for CRP 9% lower and for IL-18 1% higher than in participants with no PTSD (p values 0.53 and 0.89). However, further analyses indicated that individuals with partial PTSD had an increased chance of belonging to the highest quartile of the IL-18 concentration. No significant association was observed for any of the three subscales intrusion, avoidance or hyperarousal with CRP or IL-18 concentration. This large, population-based study could not find an association of full PTSD with CRP and IL-18 concentrations. Further research is needed to analyse these relationships. (c) 2013 Elsevier Ltd. All rights reserved.
C1 [Baumert, Jens; Lukaschek, Karoline; Emeny, Rebecca Thwing; Ladwig, Karl-Heinz] German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Inst Epidemiol 2, D-85764 Neuherberg, Germany.
   [Kruse, Johannes] Univ Giessen, Dept Psychosomat Med & Psychotherapy, D-35390 Giessen, Germany.
   [Kruse, Johannes] Univ Marburg, Dept Psychosomat Med & Psychotherapy, Marburg, Germany.
   [Koenig, Wolfgang] Univ Ulm, Dept Internal Med Cardiol 2, Med Ctr, D-89069 Ulm, Germany.
   [von Kaenel, Roland] Univ Bern, Inselspital, Div Psychosomat Med, Univ Hosp Bern, CH-3010 Bern, Switzerland.
   [von Kaenel, Roland] Univ Bern, Bern, Switzerland.
   [Ladwig, Karl-Heinz] Tech Univ Munich, Klinikum Rechts Isar, Dept Psychosomat Med & Psychotherapy, D-80290 Munich, Germany.
C3 Helmholtz Association; Helmholtz-Center Munich - German Research Center
   for Environmental Health; Justus Liebig University Giessen; Philipps
   University Marburg; Ulm University; University of Bern; University
   Hospital of Bern; University of Bern; Technical University of Munich
RP Ladwig, KH (corresponding author), German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Inst Epidemiol 2, Ingolstadter Landstr 1, D-85764 Neuherberg, Germany.
EM ladwig@helmholtz-muenchen.de
RI Emeny, Rebecca/I-1100-2014; Ladwig, Karl-Heinz/B-5351-2014; Koenig,
   Wolfgang/JCF-0788-2023; von Kanel, Roland/B-1811-2019; Lukaschek,
   Karoline/N-6224-2014
OI von Kanel, Roland/0000-0002-8929-5129; Lukaschek,
   Karoline/0000-0002-7966-2001; Koenig, Wolfgang/0000-0002-2064-9603
FU Helmholtz Zentrum Munchen, German Research Center for Environmental
   Health; German Federal Ministry of Education and Research (BMBF); State
   of Bavaria; University of Ulm
FX The KORA research platform and the KORA Augsburg studies are financed by
   the Helmholtz Zentrum Munchen, German Research Center for Environmental
   Health, which is funded by the German Federal Ministry of Education and
   Research (BMBF) and by the State of Bavaria. Part of this work was
   financed by a grant from the German Federal Ministry of Education and
   Research (BMBF) in the context of the Competence Network for Diabetes
   Mellitus. Biomarker measurements were made possible through additional
   funds from the University of Ulm.
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NR 47
TC 19
Z9 21
U1 0
U2 9
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 1043-4666
EI 1096-0023
J9 CYTOKINE
JI Cytokine
PD AUG
PY 2013
VL 63
IS 2
BP 201
EP 208
DI 10.1016/j.cyto.2013.04.033
PG 8
WC Biochemistry & Molecular Biology; Cell Biology; Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology; Immunology
GA 173OF
UT WOS:000321088100017
PM 23706403
DA 2025-06-11
ER

PT J
AU Pagliai, G
   Dinu, M
   Madarena, MP
   Bonaccio, M
   Iacoviello, L
   Sofi, F
AF Pagliai, G.
   Dinu, M.
   Madarena, M. P.
   Bonaccio, M.
   Iacoviello, L.
   Sofi, F.
TI Consumption of ultra-processed foods and health status: a systematic
   review and meta-analysis
SO BRITISH JOURNAL OF NUTRITION
LA English
DT Review
DE Ultra-processed food; Health; CVD; Mortality; Meta-analysis
ID NATIONAL-HEALTH; NUTRITION; OBESITY; RISK
AB Increasing evidence suggests that high consumption of ultra-processed foods (UPF) is associated with an increase in non-communicable diseases, overweight and obesity. The present study systematically reviewed all observational studies that investigated the association between UPF consumption and health status. A comprehensive search of MEDLINE, Embase, Scopus, Web of Science and Google Scholar was conducted, and reference lists of included articles were checked. Only cross-sectional and prospective cohort studies were included. At the end of the selection process, twenty-three studies (ten cross-sectional and thirteen prospective cohort studies) were included in the systematic review. As regards the cross-sectional studies, the highest UPF consumption was associated with a significant increase in the risk of overweight/obesity (+39 %), high waist circumference (+39 %), low HDL-cholesterol levels (+102 %) and the metabolic syndrome (+79 %), while no significant associations with hypertension, hyperglycaemia or hypertriacylglycerolaemia were observed. For prospective cohort studies evaluating a total population of 183 491 participants followed for a period ranging from 3.5 to 19 years, highest UPF consumption was found to be associated with increased risk of all-cause mortality in five studies (risk ratio (RR) 1.25, 95 % CI 1.14, 1.37; P < 0.00001), increased risk of CVD in three studies (RR 1.29, 95 % CI 1.12, 1.48; P = 0.0003), cerebrovascular disease in two studies (RR 1.34, 95 % CI 1.07, 1.68; P = 0.01) and depression in two studies (RR 1.20, 95 % CI 1.03, 1.40; P = 0.02). In conclusion, increased UPF consumption was associated, although in a limited number of studies, with a worse cardiometabolic risk profile and a higher risk of CVD, cerebrovascular disease, depression and all-cause mortality.
C1 [Pagliai, G.; Dinu, M.; Madarena, M. P.; Sofi, F.] Univ Florence, Dept Expt & Clin Med, I-50134 Florence, Italy.
   [Pagliai, G.; Dinu, M.; Sofi, F.] Careggi Univ Hosp, Unit Clin Nutr, I-50134 Florence, Italy.
   [Bonaccio, M.; Iacoviello, L.] IRCCS Neuromed, Dept Epidemiol & Prevent, I-86077 Pozzilli, Isernia, Italy.
   [Iacoviello, L.] Univ Insubria, Dept Med & Surg, Res Ctr Epidemiol & Prevent Med EPIMED, I-21100 Varese, Italy.
C3 University of Florence; University of Florence; Azienda Ospedaliero
   Universitaria Careggi; IRCCS Neuromed; University of Insubria
RP Dinu, M (corresponding author), Univ Florence, Dept Expt & Clin Med, I-50134 Florence, Italy.; Dinu, M (corresponding author), Careggi Univ Hosp, Unit Clin Nutr, I-50134 Florence, Italy.
EM monica.dinu@unifi.it
RI Iacoviello, Licia/AGX-7071-2022; Bonaccio, Marialaura/K-7678-2016; Dinu,
   Monica/I-4864-2017; Iacoviello, Licia/K-4676-2016; Pagliai,
   Giuditta/K-9592-2016; Sofi, Francesco/J-3941-2016
OI Dinu, Monica/0000-0003-1687-2527; Iacoviello, Licia/0000-0003-0514-5885;
   Pagliai, Giuditta/0000-0002-2177-2857; Sofi,
   Francesco/0000-0001-7113-7424
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NR 49
TC 622
Z9 650
U1 17
U2 135
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1145
EI 1475-2662
J9 BRIT J NUTR
JI Br. J. Nutr.
PD FEB 14
PY 2021
VL 125
IS 3
BP 308
EP 318
DI 10.1017/S0007114520002688
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA PT2MA
UT WOS:000608451700007
PM 32792031
OA hybrid, Green Published
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Shimabukuro, M
   Higa, N
   Masuzaki, H
   Sata, M
   Ueda, S
AF Shimabukuro, Michio
   Higa, Namio
   Masuzaki, Hiroaki
   Sata, Masataka
   Ueda, Shinichiro
TI Impact of individual metabolic risk components or its clustering on
   endothelial and smooth muscle cell function in men
SO CARDIOVASCULAR DIABETOLOGY
LA English
DT Article
DE Obesity; Metabolic syndrome; Endothelial function; Insulin resistance
ID FLOW-MEDIATED DILATION; INSULIN-RESISTANCE; OXIDATIVE STRESS;
   DYSFUNCTION; OBESITY; HYPERTENSION; ASSOCIATION; ADIPONECTIN;
   DEFINITION; STATEMENT
AB Background: Impaired vasoreactivity is often observed in subjects with metabolic syndrome, a condition that includes the presence of a specific cluster of risk factors for obesity and cardiovascular disease. However, hierarchical causes in the impaired vasoreactivity have not been clarified. We evaluated the impact of individual metabolic risk components or its clustering under the condition of insulin resistance on endothelial and smooth muscle cell function.
   Methods: Vascular reactivity to acetylcholine (Ach), with or without nitric oxide synthase (NOS) inhibitor N-G-monomethyl-l-arginine (L-NMMA), or sodium nitroprusside (SNP) by forearm venous occlusion plethysmography and insulin sensitivity index (M mg/kg/min) in euglycemic clamp were measured in men without (n = 18, control group) or with (n = 19, metabolic syndrome group) metabolic syndrome.
   Results: (1) Ach-induced maximal forearm blood flow (maxFBF) was impaired in subjects with metabolic syndrome. In particular, the NOS-dependent component of Ach-induced maxFBF was selectively decreased, while the NOS-independent component remained relatively unchanged. (2) Ach-induced maxFBF and Delta Ach-induced maxFBF with L-NMMA were correlated with waist circumference, glucose, and triglycerides, and most strongly correlated with visceral fat area, adiponectin, and M. (3) Multivariate regression analysis indicated that individual metabolic risk components explained Ach-induced maxFBF by 4-21 %. Clustering of all metabolic risk components increased this to 35 %, and the presence of metabolic syndrome explained 30 %, indicating that defining metabolic syndrome can effectively predict impairment of endothelial dysfunction.
   Conclusions: Endothelial dysfunction was correlated with individual metabolic risk components, but more strongly with clustering of the components under a condition with low insulin sensitivity. We suggest that in subjects with metabolic syndrome, endothelial function is impaired by multiple cardiovascular risk factors exclusively when under the condition of insulin insensitivity and also that defining metabolic syndrome can effectively predict impairment of endothelial dysfunction.
C1 [Shimabukuro, Michio] Univ Tokushima, Grad Sch, Inst Biomed Sci, Dept Cardiodiabet Med, 3-18-15 Kuramoto, Tokushima 7708503, Japan.
   [Higa, Namio] Naha City Hosp, Cardiovasc Dept, Okinawa, Japan.
   [Masuzaki, Hiroaki] Univ Ryukyus, Grad Sch Med, Div Endocrinol Diabet & Metab, Hematol,Rheumatol,Dept Internal Med 2, Okinawa, Japan.
   [Sata, Masataka] Univ Tokushima, Grad Sch, Inst Biomed Sci, Dept Cardiovasc Med, Tokushima 770, Japan.
   [Ueda, Shinichiro] Univ Ryukyus, Grad Sch Med, Dept Clin Pharmacol & Therapeut, Okinawa, Japan.
C3 Tokushima University; University of the Ryukyus; Tokushima University;
   University of the Ryukyus
RP Shimabukuro, M (corresponding author), Univ Tokushima, Grad Sch, Inst Biomed Sci, Dept Cardiodiabet Med, 3-18-15 Kuramoto, Tokushima 7708503, Japan.
EM mshimabukuro-ur@umin.ac.jp
RI Sata, Masataka/IST-9041-2023
OI Shimabukuro, Michio/0000-0001-7835-7665
FU Ministry of Education, Culture, Sports, Science and Technology, Japan
   [23591314, 24591338, 24591063]; Grants-in-Aid for Scientific Research
   [23591314, 24591063, 24591338] Funding Source: KAKEN
FX This study was supported by Grants from the Ministry of Education,
   Culture, Sports, Science and Technology, Japan, #23591314, #24591338,
   #24591063.
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NR 39
TC 14
Z9 15
U1 0
U2 4
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1475-2840
J9 CARDIOVASC DIABETOL
JI Cardiovasc. Diabetol.
PD MAY 17
PY 2016
VL 15
AR 77
DI 10.1186/s12933-016-0394-5
PG 11
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism
GA DL8SH
UT WOS:000375911200002
PM 27188597
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Lee, MY
   Hyon, DS
   Huh, JH
   Kim, HK
   Han, SK
   Kim, JY
   Koh, SB
AF Lee, Mi Young
   Hyon, Dae Sung
   Huh, Ji Hye
   Kim, Hae Kyung
   Han, Sul Ki
   Kim, Jang Young
   Koh, Sang Baek
TI Association between Serum Gamma-Glutamyltransferase and Prevalence of
   Metabolic Syndrome Using Data from the Korean Genome and Epidemiology
   Study
SO ENDOCRINOLOGY AND METABOLISM
LA English
DT Article
DE Gamma-glutamyltransferase; Metabolic syndrome; Korean Genome and
   Epidemiology Study
ID FOOD FREQUENCY QUESTIONNAIRE; MIDDLE-AGED MEN; INSULIN-RESISTANCE;
   OXIDATIVE STRESS; RISK; GLUTAMYLTRANSFERASE; ADIPONECTIN; DEFINITION;
   STATEMENT; ENZYMES
AB Background: The aim of this study was to determine whether there is a positive correlation between gamma-glutamyltransferase (GGT) levels and the prevalence of metabolic syndrome and whether GGT can be used as an easily checkable metabolic index using data from the large-scale Korean Genome and Epidemiology Study (KoGES).
   Methods: We obtained data of 211,725 participants of the KoGES. The collected data included age, sex, height, weight, waist circumference, and various biochemical characteristics, including serum GGT levels. The data of study participants who ingested more than 40 g/day of alcohol and who were diagnosed with metabolic syndrome at baseline was excluded. We analyzed the prevalence of metabolic syndrome according to GGT quartiles in both genders.
   Results: The GGT level was significantly higher in subjects with metabolic syndrome compared to normal subjects (37.92 +/- 48.20 mg/dL vs. 25.62 +/- 33.56 mg/dL). The prevalence of metabolic syndrome showed a stepwise increase with GGT quartiles in both male and female subjects. Compared to the lowest GGT quartile, the odds ratio was 1.534 (95% confidence interval [CI], 1.432 to 1.643), 1.939 (95% CI, 1.811 to 2.076), and 2.754 (95% CI, 2.572 to 2.948) in men and 1.155 (95% CI, 1.094 to 1.218), 1.528 (95% CI, 1.451 to 1.609), and 2.022 (95% CI, 1.921 to 2.218) in women with increasing GGT quartile. The cutoff value of GGT predicting risk of metabolic syndrome was 27 IU/L in men and 17 IU/L in women.
   Conclusion: We suggested that GGT could be an easily checkable marker for the prediction of metabolic syndrome.
C1 [Lee, Mi Young; Huh, Ji Hye; Kim, Hae Kyung; Han, Sul Ki; Kim, Jang Young] Yonsei Univ, Wonju Coll Med, Dept Internal Med, Wonju, South Korea.
   [Hyon, Dae Sung; Koh, Sang Baek] Yonsei Univ, Wonju Coll Med, Dept Prevent Med, 20 Ilsan Ro, Wonju 26426, South Korea.
   [Hyon, Dae Sung; Koh, Sang Baek] Yonsei Univ, Wonju Coll Med, Inst Occupat Med, Wonju, South Korea.
   [Kim, Jang Young; Koh, Sang Baek] Yonsei Univ, Wonju Coll Med, Inst Genom Cohort, Wonju, South Korea.
   [Koh, Sang Baek] Yonsei Univ, Inst Poverty Alleviat & Int Dev, Ctr Global Hlth & Social Med, Seoul, South Korea.
C3 Yonsei University; Yonsei University; Yonsei University; Yonsei
   University; Yonsei University
RP Koh, SB (corresponding author), Yonsei Univ, Wonju Coll Med, Dept Prevent Med, 20 Ilsan Ro, Wonju 26426, South Korea.
EM kohhj@yonsei.ac.kr
RI Kim, Young Hoon/F-5424-2012; Kim, Jung/S-5543-2017
OI Lee, Mi Young/0000-0002-0967-9350
FU Medical Research Center Program, Ministry of Science, ICT and Future
   Planning [2017 R1A5A2015369]
FX This study was supported by the Medical Research Center Program,
   Ministry of Science, ICT and Future Planning (2017 R1A5A2015369).
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NR 41
TC 15
Z9 15
U1 0
U2 1
PU KOREAN ENDOCRINE SOC
PI SEOUL
PA 101-2503, 109 MAPO-DAERO, MAPO-GU, SEOUL, 04146, SOUTH KOREA
SN 2093-596X
EI 2093-5978
J9 ENDOCRINOL METAB
JI Endocrinol. Metab.
PD DEC
PY 2019
VL 34
IS 4
BP 390
EP 397
DI 10.3803/EnM.2019.34.4.390
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA JZ1HW
UT WOS:000504856900008
PM 31884739
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU DeSantis, AS
   DiezRoux, AV
   Hajat, A
   Aiello, AE
   Golden, SH
   Jenny, NS
   Seeman, TE
   Shea, S
AF DeSantis, A. S.
   DiezRoux, A. V.
   Hajat, A.
   Aiello, A. E.
   Golden, S. H.
   Jenny, N. S.
   Seeman, T. E.
   Shea, S.
TI Associations of salivary cortisol levels with inflammatory markers: The
   Multi-Ethnic Study of Atherosclerosis
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE HPA axis; Cortisol; Inflammation; Cytokines
ID NECROSIS-FACTOR-ALPHA; PSYCHOLOGICAL STRESS; SOCIOECONOMIC POSITION;
   METABOLIC SYNDROME; DIURNAL RHYTHMS; PLASMA-CORTISOL; IMMUNE FUNCTION;
   CYTOKINES; INTERLEUKIN-6; RESISTANCE
AB Socioeconomic and psychosocial factors have been found to be associated with systemic inflammation. Although stress is often proposed as a contributor to these associations, no population studies have investigated the links between inflammation and biomarkers of stress. The current study examines associations between daily cortisol profiles and inflammatory markers interleukin-6 (IL-6), interleukin-10 (IL-10), and tumor necrosis factor (TNF-a) in a population-based sample of 869 adults with repeat measures of cortisol over multiple days. Persons with higher levels of IL-6 had a less pronounced cortisol awakening response, a less steep daily decline, and higher cortisol area under the curve for the day with associations persisting after controls for risk factors and other cytokines. Persons with higher levels of TNF-a had lower cortisol levels upon waking, and flatter daily decline, although associations with decline were attenuated when controlling for inflammatory risk factors. Higher levels of IL-10 were associated with marginally flatter daily cortisol decline (p < .10). This study is the first to identify associations of basal cortisol activity and inflammatory markers in a population based sample. Findings are consistent with the possibility that HPA axis activity may mediate associations between psychosocial stressors and inflammatory processes. Additional prospective data are necessary to clarify the directionality of associations between cortisol and inflammatory markers. (c) 2011 Elsevier Ltd. All rights reserved.
C1 [DeSantis, A. S.] Univ Michigan, Dept Epidemiol SPH1, Ann Arbor, MI 48109 USA.
   [Golden, S. H.] Johns Hopkins Univ, Baltimore, MD 21218 USA.
   [Jenny, N. S.] Univ Vermont, Burlington, VT 05405 USA.
   [Seeman, T. E.] Univ Calif Los Angeles, Los Angeles, CA USA.
   [Shea, S.] Columbia Univ, New York, NY 10027 USA.
C3 University of Michigan System; University of Michigan; Johns Hopkins
   University; University of Vermont; University of California System;
   University of California Los Angeles; Columbia University
RP DeSantis, AS (corresponding author), Univ Michigan, Dept Epidemiol SPH1, 1415 Washington Hts, Ann Arbor, MI 48109 USA.
EM amydes@umich.edu
OI Hajat, Anjum/0000-0001-8807-9232; Aiello, Allison/0000-0001-7029-2537
FU National Heart, Lung, and Blood Institute (NHLBI) [N01-HC-95159,
   N01-HC-95169]; National Institutes of Health (NIH) [1R01HL101161, R21
   DA024273];  [P60 MD002249]
FX Funding for this study was provided by National Heart, Lung, and Blood
   Institute (NHLBI) contracts N01-HC-95159 through N01-HC-95169 and
   National Institutes of Health (NIH) grants 1R01HL101161 and R21
   DA024273. This work was also partly supported by P60 MD002249. The NHLBI
   and NIH had no further role in the study design; in the collection,
   analysis and interpretation of data; in the writing of the report; or in
   the decision to submit the paper for publication.
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NR 53
TC 101
Z9 109
U1 0
U2 16
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD JUL
PY 2012
VL 37
IS 7
BP 1009
EP 1018
DI 10.1016/j.psyneuen.2011.11.009
PG 10
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA 957XC
UT WOS:000305199400014
PM 22178583
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Ryan, JG
   Gajraj, J
AF Ryan, John G.
   Gajraj, Jason
TI Erectile dysfunction and its association with metabolic syndrome and
   endothelial function among patients with type 2 diabetes mellitus
SO JOURNAL OF DIABETES AND ITS COMPLICATIONS
LA English
DT Review
DE Diabetes; Sexual dysfunction; Erectile dysfunction; Comorbidity; Primary
   care
ID QUALITY-OF-LIFE; SEXUAL DYSFUNCTION; TESTOSTERONE DEFICIENCY;
   INSULIN-RESISTANCE; RISK-FACTORS; WEIGHT-LOSS; OBESITY; MEN; PREVALENCE;
   SMOKING
AB Context: Evidence suggests that numerous comorbid conditions contribute to erectile dysfunction (ED) among patients with type 2 diabetes mellitus (T2DM).
   Objective: To review the relationship and mechanism between diabetes, metabolic syndrome, cardiovascular disease (CVD), and ED.
   Methods: A manual review of authoritative literature from peer-reviewed publications from January 2001 through July 2010 was performed. These publications were further mined to consider the impact of metabolic syndrome as a comorbid condition. Publications from key references were also consulted.
   Results: The associations between obesity, dyslipidemia, metabolic syndrome, T2DM, CVD, and depression with sexual dysfunction suggest that sexual dysfunction, particularly ED, is a precursor to CVD. Because these conditions share important risk factors with CVD, identifying them and their relationships with the pathogenesis of ED is likely to be critical to the manner in which primary care physicians screen for and manage this condition.
   Conclusions: Primary care physicians ought to establish trusting relationships with their patients, providing opportunities for them to probe such sensitive issues as sexual activities, as a means of addressing the possibility of ED. When making the new diagnosis of sexual dysfunction in the absence of metabolic disease or CVD, physicians ought to consider the risk for T2DM and CVD. Associations between metabolic disease, heart disease, and sexual dysfunction further suggest that all patients who are obese and have dyslipidemia, T2DM, and/or depression should be further screened for ED. (C) 2012 Elsevier Inc. All rights reserved.
C1 [Ryan, John G.] Univ Miami, Miller Sch Med, Dept Family Med & Community Hlth, Div Primary Care Hlth Serv Res & Dev, Miami, FL 33136 USA.
   [Gajraj, Jason] Danbury Hosp, Internal Med Residency Program, Danbury, CT USA.
C3 University of Miami
RP Ryan, JG (corresponding author), POB 016700,R-700, Miami, FL 33101 USA.
EM JGRyan@med.miami.edu
RI RYAN, JOHN/C-1012-2008
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NR 78
TC 38
Z9 52
U1 0
U2 12
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1056-8727
EI 1873-460X
J9 J DIABETES COMPLICAT
JI J. Diabetes Complications
PD MAR-APR
PY 2012
VL 26
IS 2
BP 141
EP 147
DI 10.1016/j.jdiacomp.2011.12.001
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 944TC
UT WOS:000304225700015
PM 22437118
DA 2025-06-11
ER

PT J
AU Calmasini, FB
   de Oliveira, MG
   Alexandre, EC
   Silva, FH
   Tavares, EBG
   André, DM
   Zapparoli, A
   Antunes, E
AF Calmasini, Fabiano B.
   de Oliveira, Mariana G.
   Alexandre, Eduardo C.
   Silva, Fabio Henrique
   Tavares, Edith B. G.
   Andre, Diana M.
   Zapparoli, Adriana
   Antunes, Edson
TI Obesity-induced mouse benign prostatic hyperplasia (BPH) is improved by
   treatment with resveratrol: implication of oxidative stress, insulin
   sensitivity and neuronal growth factor
SO JOURNAL OF NUTRITIONAL BIOCHEMISTRY
LA English
DT Article
DE Reactive oxygen species; Growth factor; gp91phox; AKT; Stereology;
   High-fat diet
ID METABOLIC SYNDROME; DIET
C1 [Calmasini, Fabiano B.; de Oliveira, Mariana G.; Alexandre, Eduardo C.; Tavares, Edith B. G.; Andre, Diana M.; Antunes, Edson] Univ Campinas UNICAMP, Fac Med Sci, Dept Pharmacol, Campinas, SP, Brazil.
   [Silva, Fabio Henrique] Univ Campinas UNICAMP, Hematol & Hemotherapy Ctr, Campinas, SP, Brazil.
   [Zapparoli, Adriana] Univ Campinas UNICAMP, Hydrossaline Metab Lab, Campinas, SP, Brazil.
C3 Universidade Estadual de Campinas; Universidade Estadual de Campinas;
   Universidade Estadual de Campinas
RP Calmasini, FB (corresponding author), Univ Estadual Campinas, Dept Pharmacol, Fac Med Sci, BR-13084971 Campinas, SP, Brazil.
EM fabiano.b.calmasini@gmail.com
RI Alexandre, Eduardo/D-3797-2013; Antunes, Edson/KRP-5678-2024; Tavares,
   Edith/AAB-5935-2021; Zapparoli, Adriana/ABE-4385-2021; SILVA,
   FABIO/AAZ-8140-2020; André, Diana/N-3160-2013; Calmasini,
   Fabiano/S-9691-2019; Silva, Fabio/D-5412-2013
OI Beraldi Calmasini, Fabiano/0000-0002-7790-2550; Silva,
   Fabio/0000-0003-3374-5570; Tavares, Edith/0000-0002-1793-5860
FU Fundacao de Amparo a Pesquisa do Estado de sao Paulo (FAPESP)
   [2016/01178-6]; Fundacao de Amparo a Pesquisa do Estado de Sao Paulo
   (FAPESP) [16/01178-6] Funding Source: FAPESP
FX This work was supported by Fundacao de Amparo a Pesquisa do Estado de
   sao Paulo (FAPESP; grant number 2016/01178-6).
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   Wang S, 2014, J NUTR BIOCHEM, V25, P1, DOI 10.1016/j.jnutbio.2013.09.001
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NR 42
TC 18
Z9 20
U1 0
U2 14
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0955-2863
EI 1873-4847
J9 J NUTR BIOCHEM
JI J. Nutr. Biochem.
PD MAY
PY 2018
VL 55
BP 53
EP 58
DI 10.1016/j.jnutbio.2017.12.009
PG 6
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA GG1CD
UT WOS:000432416000005
PM 29413489
DA 2025-06-11
ER

PT J
AU Zhang, X
   Yan, SM
   Zheng, HL
   Hu, DH
   Zhang, YT
   Guan, QH
   Ding, QL
AF Zhang, X.
   Yan, S. M.
   Zheng, H. L.
   Hu, D. H.
   Zhang, Y. T.
   Guan, Q. H.
   Ding, Q. L.
TI A Mechanism Underlying Hypertensive Occurrence in the Metabolic
   Syndrome: Cooperative Effect of Oxidative Stress and Calcium
   Accumulation in Vascular Smooth Muscle Cells
SO HORMONE AND METABOLIC RESEARCH
LA English
DT Article
ID ANGIOTENSIN-II; CARDIOVASCULAR-DISEASE; MITOCHONDRIAL-MEMBRANE;
   INSULIN-RESISTANCE; PROTEIN-KINASE; INVOLVEMENT; ACTIVATION; CA2+;
   DYSFUNCTION; OXIDASE
C1 [Zhang, X.; Yan, S. M.; Zheng, H. L.; Hu, D. H.; Zhang, Y. T.; Guan, Q. H.; Ding, Q. L.] China Pharmaceut Univ, Expt & Teaching Ctr Med Basis Pharm, Nanjing, Jiangsu, Peoples R China.
C3 China Pharmaceutical University
RP Ding, QL (corresponding author), China Pharmaceut Univ, Expt & Teaching Ctr Med Basis Pharm, Longmian Ave 639, Nanjing, Jiangsu, Peoples R China.
EM g637cpu@163.com
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NR 34
TC 21
Z9 21
U1 0
U2 4
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0018-5043
EI 1439-4286
J9 HORM METAB RES
JI Horm. Metab. Res.
PD FEB
PY 2014
VL 46
IS 2
BP 126
EP 132
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA AA8GY
UT WOS:000331334800008
PM 24108391
DA 2025-06-11
ER

PT J
AU Ismail, B
   Aboul-Fotouh, S
   Mansour, AA
   Shehata, HH
   Salman, MI
   Ibrahim, EA
   Hassan, OA
   Abdel-tawab, AM
AF Ismail, Basma
   Aboul-Fotouh, Sawsan
   Mansour, Amal A.
   Shehata, Hanan H.
   Salman, Manal I.
   Ibrahim, Eman A.
   Hassan, Olfat A.
   Abdel-tawab, Ahmed M.
TI Behavioural, metabolic, and endothelial effects of the TNF-α suppressor
   thalidomide on rats subjected to chronic mild stress and fed an
   atherogenic diet
SO CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
LA English
DT Article
DE thalidomide; depression; vascular dysfunction; TNF-alpha; insulin
   resistance
ID INSULIN-RESISTANCE; CARDIOVASCULAR-DISEASE; MYOCARDIAL-INFARCTION;
   VASCULAR DYSFUNCTION; INDUCED ANHEDONIA; MAJOR DEPRESSION; DEFICIENT
   MICE; ATHEROSCLEROSIS; CHOLESTEROL; ARTERY
AB There is accumulating evidence suggesting that depression is a risk factor for cardiovascular diseases. This study aimed to examine the hypothesis that the proinflammatory cytokine TNF-alpha would partially explain the link between depression and atherosclerotic endothelial changes. Rats were distributed among 6 groups: (i) control group; (ii) group subjected to chronic mild stress (CMS); (iii) group fed a cholesterol-cholic acid-thiouracil (CCT diet); and (iv) CMS group fed the CCT diet and treated with the vehicle for 8 weeks. The last 2 groups were subjected to CMS-CCT and received thalidomide (THAL) or imipramine (IMIP). Rats were assessed behaviorally (sucrose preference, open field, and forced-swimming tests). TNF-alpha protein was assessed from the serum, aorta, and liver. Aortic TNF-alpha gene expression (assessed using RT-PCR), serum lipid profile, and insulin levels were measured. Endothelial function was assessed in isolated aortic rings. The THAT. and IMIP groups showed ameliorated CMS-CCT-related behavioral changes. CMS-CCT-induced metabolic and endothelial dysfunctions were improved in the THAL group but were worsened in the IMIP group. RT-PCR showed a significant reduction of aortic TNF-alpha mRNA expression in the THAL and IMIP treatment groups. These data paralleled the findings for aortic immunohistochemistry. The THAL group, but not the IMIP group, showed improved CMS-CCT-induced changes in the vascular reactivity of the aortic rings. Thus, TNF-alpha provides a target link between depression, metabolic syndrome, and endothelial dysfunction. This could open a new therapeutic approach to address the comorbidities of depression.
C1 [Ismail, Basma; Aboul-Fotouh, Sawsan; Hassan, Olfat A.; Abdel-tawab, Ahmed M.] Ain Shams Univ, Fac Med, Dept Pharmacol, Cairo, Egypt.
   [Ismail, Basma] Univ Ottawa, Inst Heart, Cardiac PET Ctr, Ottawa, ON K1Y 4W7, Canada.
   [Aboul-Fotouh, Sawsan; Abdel-tawab, Ahmed M.] Ain Shams Univ, Fac Med, Clin Pharmacol Unit, Cairo, Egypt.
   [Mansour, Amal A.; Shehata, Hanan H.] Ain Shams Univ, Dept Med Biochem, Fac Med, Cairo, Egypt.
   [Salman, Manal I.; Ibrahim, Eman A.] Ain Shams Univ, Dept Pathol, Fac Med, Cairo, Egypt.
C3 Egyptian Knowledge Bank (EKB); Ain Shams University; University of
   Ottawa; University of Ottawa Heart Institute; Egyptian Knowledge Bank
   (EKB); Ain Shams University; Egyptian Knowledge Bank (EKB); Ain Shams
   University; Egyptian Knowledge Bank (EKB); Ain Shams University
RP Aboul-Fotouh, S (corresponding author), Ain Shams Univ, Fac Med, Dept Pharmacol, Cairo, Egypt.
EM sawsanaf2005@yahoo.com
RI ; Abdel-tawab, Ahmed M./C-1432-2009
OI Mansour, Amal/0000-0003-2544-2705; salman, manal/0000-0002-0478-2172;
   Abdel-tawab, Ahmed M./0000-0001-6412-7404; Ibrahim,
   Eman/0000-0002-1916-3681
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NR 54
TC 17
Z9 17
U1 0
U2 11
PU CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS
PI OTTAWA
PA 65 AURIGA DR, SUITE 203, OTTAWA, ON K2E 7W6, CANADA
SN 0008-4212
EI 1205-7541
J9 CAN J PHYSIOL PHARM
JI Can. J. Physiol. Pharmacol.
PD MAY
PY 2014
VL 92
IS 5
BP 375
EP 385
DI 10.1139/cjpp-2013-0446
PG 11
WC Pharmacology & Pharmacy; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Physiology
GA AG8CY
UT WOS:000335647600007
PM 24754268
DA 2025-06-11
ER

PT J
AU Reda, D
   Elshopakey, GE
   Mahgoub, HA
   Risha, EF
   Khan, AA
   Rajab, BS
   El-Boshy, ME
   Abdelhamid, FM
AF Reda, Doha
   Elshopakey, Gehad E.
   Mahgoub, Hebatallah A.
   Risha, Engy F.
   Khan, Anmar A.
   Rajab, Bodour S.
   El-Boshy, Mohamed E.
   Abdelhamid, Fatma M.
TI Effects of Resveratrol Against Induced Metabolic Syndrome in Rats: Role
   of Oxidative Stress, Inflammation, and Insulin Resistance
SO EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Article
ID FATTY LIVER-DISEASE; DIET-INDUCED OBESITY; NF-KAPPA-B; HIGH-FRUCTOSE;
   CARDIOVASCULAR DYSFUNCTION; HEPATIC STEATOSIS; GENE-EXPRESSION;
   MESSENGER-RNA; MICE; PATHWAY
AB Metabolic syndrome (MS) is a serious health problem associated with an increase in risk factors for hepatic steatosis, which is the most common liver disease today. The goal of this study was to investigate the protective effects of resveratrol against metabolic alterations associated with a high-fat high-fructose diet (HFFD). Thirty-two male rats were randomly divided into four equal groups: control (cont.), metabolic syndrome (MS), resveratrol (Res), and metabolic syndrome treated with resveratrol (MS + Res). Resveratrol was administrated orally at a dose of 30 mg/kg center dot bw, daily. After 10 weeks, body weight, serum biochemical parameters, hepatic oxidative stress, inflammatory markers, as well as mRNA levels of hepatic genes related to lipid metabolism and insulin signaling were measured. In addition, the liver was examined histopathologically to detect lipid deposition. Increased body weight, hepatic dysfunction, dyslipidemia, hepatic insulin resistance, hepatic oxidative and inflammatory stress conditions, upregulation of mRNA expression level of sterol regulatory element binding protein 1-c (SREBP1-c), and downregulation of mRNA expression levels of peroxisome proliferated activated receptor alpha (PPAR alpha) and insulin receptor substrate-2 (IR-S2) were all observed in the MS rats. Hepatic steatosis was confirmed by hematoxylin and eosin and Oil Red O staining. Administration of resveratrol reduced liver steatosis, oxidative stress, and inflammatory state. Also, it improved lipid profile as well as insulin sensitivity and reverted alterations in hepatic mRNA expression levels of the tested genes. Based on these findings, resveratrol could be proposed as a therapeutic approach for MS prevention.
C1 [Reda, Doha; Elshopakey, Gehad E.; Risha, Engy F.; El-Boshy, Mohamed E.; Abdelhamid, Fatma M.] Mansoura Univ, Fac Vet Med, Dept Clin Pathol, Mansoura 35516, Egypt.
   [Mahgoub, Hebatallah A.] Mansoura Univ, Fac Vet Med, Dept Pathol, Mansoura 35516, Egypt.
   [Khan, Anmar A.; Rajab, Bodour S.] Umm Al Qura Univ, Fac Appl Med Sci, Lab Med Dept, POB 7607, Al Abdeyah, Makkah, Saudi Arabia.
C3 Egyptian Knowledge Bank (EKB); Mansoura University; Egyptian Knowledge
   Bank (EKB); Mansoura University; Umm Al-Qura University
RP Abdelhamid, FM (corresponding author), Mansoura Univ, Fac Vet Med, Dept Clin Pathol, Mansoura 35516, Egypt.
EM dohareda704@gmail.com; gehadelshobaky@yahoo.com;
   heba.a.mahgoub@gmail.com; engyrisha@yahoo.com; aaakhan@uqu.edu.sa;
   bsrajab@uqu.edu.sa; dr_elboshy@yahoo.com; fatmamostafa980@yahoo.com
RI Khan, Anmar/JBS-5090-2023; Risha, Engy/L-7830-2018; Elshopakey,
   Gehad/GQB-2109-2022; Reda, Doha/GMX-1288-2022; Elshopakey,
   Gehad/P-8872-2018; El-Boshy, Mohamed/N-2013-2018; M Abdelhamid,
   Fatma/AAA-9916-2020; Khan, Anmar/C-5855-2019
OI Rajab, Bodour/0000-0002-3874-9434; Elshopakey,
   Gehad/0000-0003-2924-9670; El-Boshy, Mohamed/0000-0001-5022-1600; M
   Abdelhamid, Fatma/0000-0003-0256-6828; Khan, Anmar/0000-0002-1463-8609;
   Reda, Doha/0000-0002-3654-9340; Mahgoub, H. A./0000-0001-5832-9376
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NR 76
TC 6
Z9 6
U1 1
U2 9
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1741-427X
EI 1741-4288
J9 EVID-BASED COMPL ALT
JI Evid.-based Complement Altern. Med.
PD AUG 11
PY 2022
VL 2022
AR 3362005
DI 10.1155/2022/3362005
PG 13
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA 3Y0BP
UT WOS:000843396100011
PM 35990819
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Johnson, DA
   Knutson, K
   Colangelo, LA
   Hale, L
   Redline, S
   Carnethon, M
   Kershaw, KN
AF Johnson, Dayna A.
   Knutson, Kristen
   Colangelo, Laura A.
   Hale, Lauren
   Redline, Susan
   Carnethon, Mercedes
   Kershaw, Kiarri N.
TI Associations of Chronic Burden, Sleep Characteristics, and Metabolic
   Syndrome in the Coronary Artery Risk Development in Young Adults Study
SO PSYCHOSOMATIC MEDICINE
LA English
DT Article
DE chronic stress; sleep; actigraphy; metabolic syndrome; CARDIA = Coronary
   Artery Risk Development in Young Adults Study; CVD = cardiovascular
   disease; HDL = high-density lipoproteins; PSQI = Pittsburgh Sleep
   Quality Index; MetS = metabolic syndrome
ID LONGITUDINAL ASSOCIATIONS; PSYCHOSOCIAL STRESSORS; DEPRESSIVE SYMPTOMS;
   AFRICAN-AMERICANS; PERCEIVED STRESS; HEALTH; DURATION; PREVALENCE;
   DISCRIMINATION; VULNERABILITY
AB Objective Chronic exposure to stress is associated with metabolic syndrome (MetS), but the mechanism is unclear. We investigated the associations between chronic burden, sleep, and MetS in the Coronary Artery Risk Development in Young Adults Study. Methods Chronic burden was self-reported (2000-2001) according to experiences with stressors for longer than 6 months. Wrist actigraphy-measured sleep duration and sleep efficiency were collected for 6 days; sleep duration, sleep quality, and daytime sleepiness were self-reported (2003-2004). MetS was measured during the clinic visit, from 2005 to 2006. Multivariable logistic and Cox proportional hazard models were fit to determine the associations of interest. Mediation by sleep was assessed using the product of coefficients approach. Results Among participants (n = 606), the average (standard deviation) age was 40 (3.6) years, 58% were female, and 43% were Black. The prevalences of chronic burden, short sleep (<= 6 hours), and MetS were 35%, 43% and 20.5%, respectively. High versus low chronic burden was associated with shorter self-reported sleep duration and higher daytime sleepiness. Chronic burden was associated with 1.85 higher odds (95% confidence interval = 1.11-3.09) of MetS. Sleep characteristics were not associated with MetS. There was no evidence that sleep mediated the chronic burden-MetS relation. Conclusion Burden of chronic stress may be an emerging novel risk factor for both poor sleep and MetS.
C1 [Johnson, Dayna A.] Emory Univ, Rollins Sch Publ Hlth, Dept Epidemiol, 1518 Clifton Rd NE,Room 3025, Atlanta, GA 30322 USA.
   [Johnson, Dayna A.; Redline, Susan] Brigham & Womens Hosp, Div Sleep & Circadian Disorders, 75 Francis St, Boston, MA 02115 USA.
   [Colangelo, Laura A.; Carnethon, Mercedes; Kershaw, Kiarri N.] Northwestern Univ, Feinberg Sch Med, Dept Prevent Med, Chicago, IL 60611 USA.
   [Knutson, Kristen] Northwestern Univ, Feinberg Sch Med, Dept Neurol, Chicago, IL 60611 USA.
   [Hale, Lauren] SUNY Stony Brook, Renaissance Sch Med, Dept Family Populat & Prevent Med, Stony Brook, NY 11794 USA.
   [Redline, Susan] Harvard Med Sch, Div Sleep Med, Boston, MA 02115 USA.
C3 Emory University; Rollins School Public Health; Harvard University;
   Harvard University Medical Affiliates; Brigham & Women's Hospital;
   Northwestern University; Feinberg School of Medicine; Northwestern
   University; Feinberg School of Medicine; State University of New York
   (SUNY) System; Stony Brook University; Stony Brook University Hospital;
   Harvard University; Harvard Medical School
RP Johnson, DA (corresponding author), Emory Univ, Rollins Sch Publ Hlth, Dept Epidemiol, 1518 Clifton Rd NE,Room 3025, Atlanta, GA 30322 USA.
EM dayna.johnson@emory.edu
RI Hale, Lauren/K-3227-2013; Johnson-Morgan, Dayna/HTM-2150-2023
OI Johnson, Dayna/0000-0002-2617-1639; Knutson, Kristen/0000-0002-2751-6168
FU National Heart, Lung, and Blood Institute [K01HL138211]; National Heart,
   Lung and Blood Institute; University of Alabama at Birmingham
   [HHSN268201800005I, HHSN268201800007I]; Northwestern University
   [HHSN268201800003I]; University of Minnesota [HHSN268201800006I]; Kaiser
   Foundation Research Institute [HHSN268201800004I]; National Heart Lung
   and Blood Institute [K01HL138211] Funding Source: NIH RePORTER
FX This work was supported by the National Heart, Lung, and Blood Institute
   (grant K01HL138211; D.A.J.). The Coronary Artery RiskDevelopment in
   Young Adults Study is conducted and supported by the National Heart,
   Lung and Blood Institute in collaboration with the University of Alabama
   at Birmingham (grants HHSN268201800005I and HHSN268201800007I),
   Northwestern University (grant HHSN268201800003I), the University of
   Minnesota (grant HHSN268201800006I), and the Kaiser Foundation Research
   Institute (grant HHSN268201800004I). This manuscript has been reviewed
   by CARDIA for scientific content. The authors have no conflict of
   interest to report.
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NR 46
TC 5
Z9 5
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0033-3174
EI 1534-7796
J9 PSYCHOSOM MED
JI Psychosom. Med.
PD JUL-AUG
PY 2022
VL 84
IS 6
BP 711
EP 718
DI 10.1097/PSY.0000000000001081
PG 8
WC Psychiatry; Psychology; Psychology, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry; Psychology
GA 2S8XC
UT WOS:000822069400013
PM 35420593
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Moisan, MP
AF Moisan, Marie-Pierre
TI Genotype-phenotype associations in understanding the role of
   corticosteroid-binding globulin in health and disease animal models
SO MOLECULAR AND CELLULAR ENDOCRINOLOGY
LA English
DT Review
DE Corticosteroid-binding globulin; Transcortin; Glucocorticoids; Stress;
   Genetics
ID QUANTITATIVE TRAIT LOCI; INSULIN-RESISTANCE SYNDROME; GENETIC-ANALYSIS;
   STRESS-RESPONSE; CORTISOL-LEVELS; RAT; IDENTIFICATION; OBESE;
   SUSCEPTIBILITY; EXPRESSION
AB Corticosteroid-binding globulin (CBG) is a plasma glycoprotein discovered more than 60 years ago for its high-affinity for glucocorticoids. Although its molecular structure and its biochemical properties have been described, its various biological roles and its importance are not yet fully understood. This review focuses first on studies that have used no-hypothesis-driven genetic approaches in animal models to reveal the higher than expected importance of CBG in particular in glucocorticoid stress responses. Then the dissection of some CBG physiological roles in an animal model of genetic CBG deficiency is reported. Finally, studies on the role of CBG genetic variability in human obesity traits are reviewed and discussed. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
C1 Univ Bordeaux 2, CNRS 5226, UMR PsyNuGen 1286, INRA, F-33076 Bordeaux, France.
C3 INRAE; Universite de Bordeaux
RP Moisan, MP (corresponding author), Univ Bordeaux 2, CNRS 5226, UMR PsyNuGen 1286, INRA, 146 Rue Leo Saignat, F-33076 Bordeaux, France.
EM mpmoisan@bordeaux.inra.fr
RI Moisan, Marie-Pierre/AAO-9971-2021
OI Moisan, Marie-Pierre/0000-0001-7315-5319
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NR 82
TC 32
Z9 32
U1 0
U2 7
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0303-7207
EI 1872-8057
J9 MOL CELL ENDOCRINOL
JI Mol. Cell. Endocrinol.
PD MAR 5
PY 2010
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SI SI
BP 35
EP 41
DI 10.1016/j.mce.2009.07.017
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WC Cell Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Endocrinology & Metabolism
GA 553LR
UT WOS:000274368700005
PM 19643164
DA 2025-06-11
ER

PT J
AU Panzhinskiy, E
   Ren, J
   Nair, S
AF Panzhinskiy, E.
   Ren, J.
   Nair, S.
TI Pharmacological Inhibition of Protein Tyrosine Phosphatase 1B: A
   Promising Strategy for the Treatment of Obesity and Type 2 Diabetes
   Mellitus
SO CURRENT MEDICINAL CHEMISTRY
LA English
DT Article
DE Cell signaling; ER stress; insulin resistance; insulin signaling; leptin
   signaling; obesity; PTP1B; PTP1B inhibitors; type 2 diabetes
ID ENDOPLASMIC-RETICULUM STRESS; CARBOXYLIC-ACID DERIVATIVES; MECHANISMS
   LINKING OBESITY; LIVER-SPECIFIC DELETION; PTP1B INHIBITORS;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; INTERACTION REQUIREMENTS;
   ALLOSTERIC INHIBITION; BIOLOGICAL EVALUATION
AB Obesity and metabolic syndrome represent major public health problems, and are the biggest preventable causes of death worldwide. Obesity is the leading risk factor for type 2 diabetes mellitus (T2DM), cardiovascular diseases and non-alcoholic fatty liver disease. Obesity-associated insulin resistance, which is characterized by reduced uptake and utilization of glucose in muscle, adipose and liver tissues, is a key predictor of metabolic syndrome and T2DM. With increasing prevalence of obesity in adults and children, the need to identify and characterize potential targets for treating metabolic syndrome is imminent. Emerging evidence from animal models, clinical studies and cell lines studies suggest that protein tyrosine phosphatase 1B (PTP1B), an enzyme that negatively regulates insulin signaling, is likely to be involved in the pathways leading to insulin resistance. PTP1B is tethered to the cytosolic surface of endoplasmic reticulum (ER), an organelle that is responsible for folding, modification, and trafficking of proteins. Recent evidence links the disruption of ER homeostasis, referred to as ER stress, to the pathogenesis of obesity and T2DM. PTP1B has been recognized as an important player linking ER stress and insulin resistance in obese subjects. This review highlights recent advances in the research related to the role of PTP1B in signal transduction processes implicated in pathophysiology of obesity and type 2 diabetes, and focuses on the potential therapeutic exploitation of PTP1B inhibitors for the management of these conditions.
C1 Univ Wyoming, Coll Hlth Sci, Div Pharmaceut Sci, Laramie, WY 82071 USA.
   [Nair, S.] Univ Wyoming, Coll Hlth Sci, Ctr Cardiovasc Res & Alternat Med, Laramie, WY 82071 USA.
C3 University of Wyoming; University of Wyoming
RP Nair, S (corresponding author), Univ Wyoming, Coll Hlth Sci, Ctr Cardiovasc Res & Alternat Med, Laramie, WY 82071 USA.
EM sreejay@uwyo.edu
RI Ren, Jun/ACG-5366-2022
OI Ren, Jun/0000-0002-0275-0783
FU National Center for Research Resources [5P20RR016474-12]; National
   Institute of General Medical Sciences from the National Institutes of
   Health [8 P20 GM103432-12]
FX This work was supported by grants from the National Center for Research
   Resources (5P20RR016474-12) and the National Institute of General
   Medical Sciences (8 P20 GM103432-12) from the National Institutes of
   Health.
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NR 145
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PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 0929-8673
EI 1875-533X
J9 CURR MED CHEM
JI Curr. Med. Chem.
PD JUL
PY 2013
VL 20
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BP 2609
EP 2625
DI 10.2174/0929867311320210001
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WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Pharmacology &
   Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
GA 160ZB
UT WOS:000320158000001
PM 23627940
DA 2025-06-11
ER

PT J
AU Inoguchi, T
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AF Inoguchi, T
   Nawata, H
TI NAD(P)H oxidase activation: A potential target mechanism for diabetic
   vascular complications, progressive β-cell dysfunction and metabolic
   syndrome
SO CURRENT DRUG TARGETS
LA English
DT Review
DE NAD(P)H oxidase; oxidative stress; protein kinase C; diabetic
   complications; atherosclerosis; beta-cell; adipocyte; metabolic syndrome
ID PROTEIN-KINASE-C; INCREASED OXIDATIVE STRESS; FREE-RADICAL PRODUCTION;
   SUPEROXIDE-PRODUCTION; ANGIOTENSIN-II; CARDIOVASCULAR-DISEASE; REDUCTASE
   INHIBITORS; GLUCOSE TOXICITY; NADH-OXIDASE; DNA-DAMAGE
AB Both protein kinase C (PKC) activation and increased oxidative stress have been paid attention to as important causative factors for diabetic vascular complications. In this article, we show a PKC-dependent increase in oxidative stress in vascular tissues of diabetes and insulin resistant state. High glucose level and free fatty acids stimulate de novo diacylglycerol (DAG)-PKC pathway and subsequently stimulate reactive oxygen species (ROS) production through a PKC-dependent activation of NAD(P)H oxidase. Increasing evidence has also shown that NAD(P)H oxidase components are upregulated in micro- and macro-vascular tissues of animal models and patients of diabetes and obesity. It is also noted that increased intrinsic angiotensin II production may amplify such a PKC-dependent activation of NAD(P)H oxidase in diabetic vascular tissues. These mechanisms may play an important role in the diabetic vascular complications and the accelerated atherosclerosis associated with diabetes and obesity. In addition, recent reports have shown that NAD(P)H oxidases exist in pancreatic beta-cells and adipocytes, and this oxidase-generated ROS production may play an important role in both the progressive beta-cell dysfunction and the dysregulated adipocytokine production and subsequent obesity-induced metabolic syndrome. These results suggest that an NAD(P)H oxidase activation may be a useful therapeutic target for preventing diabetic vascular complications, progressive beta-cell dysfunction and metabolic syndrome.
C1 Kyushu Univ, Grad Sch Med Sci, Dept Med & Bioregulatory Sci, Fukuoka 8128582, Japan.
C3 Kyushu University
RP Kyushu Univ, Grad Sch Med Sci, Dept Med & Bioregulatory Sci, Fukuoka 8128582, Japan.
EM toyoshi@intmed.3.med.kyusliu-u.ac.jp
OI Inoguchi, Toyoshi/0000-0002-7344-6199
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NR 82
TC 90
Z9 109
U1 0
U2 4
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1389-4501
EI 1873-5592
J9 CURR DRUG TARGETS
JI Curr. Drug Targets
PD JUN
PY 2005
VL 6
IS 4
BP 495
EP 501
DI 10.2174/1389450054021927
PG 7
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 939TT
UT WOS:000230096000014
PM 16026268
DA 2025-06-11
ER

PT J
AU Shimizu, K
   Ono, M
   Imoto, A
   Nagayama, H
   Tetsumura, N
   Terada, T
   Tomita, K
   Nishinaka, T
AF Shimizu, Kahori
   Ono, Moe
   Imoto, Akane
   Nagayama, Hideki
   Tetsumura, Naho
   Terada, Tomoyuki
   Tomita, Koji
   Nishinaka, Toru
TI Cranberry Attenuates Progression of Non-alcoholic Fatty Liver Disease
   Induced by High-Fat Diet in Mice
SO BIOLOGICAL & PHARMACEUTICAL BULLETIN
LA English
DT Article
DE cranberry; non-alcoholic fatty liver disease (NAFLD); oxidative stress;
   obesity; metabolic syndrome
ID OXIDATIVE STRESS; INSULIN-RESISTANCE; AMERICAN ASSOCIATION; OBESITY;
   STEATOHEPATITIS; INFLAMMATION; PATHOGENESIS; MANAGEMENT; STEATOSIS;
   DIAGNOSIS
AB Obesity is characterized by abnormal or excessive fat accumulation, which leads to the development of metabolic syndrome. Because oxidative stress is increased in obesity, antioxidants are regarded as suitable agents for preventing metabolic syndrome. Here, we examined the impact of cranberry, which contains various antioxidants, on metabolic profiles, including that during the progression of non-alcoholic fatty liver disease (NAFLD), in high-fat diet (HFD)-fed C57BL/6 mice. We observed that oxidative stress was diminished in mice that were fed HFD diets supplemented with 1 and 5% cranberry powder as compared with that in HFD-fed control mice. Notably, from 1 week after beginning the diets to the end of the study, the body weight of mice in the cranberry-treatment groups was significantly lower than that of mice in the HFD-fed control group; during the early treatment phase, cranberry suppressed the elevation of serum triglycerides; and adipocytes in the adipose tissues of cranberry-supplemented-HFD-fed mice were smaller than these cells in HFD-fed control mice. Lastly, we examined the effect of cranberry on NAFLD, which is one of the manifestations of metabolic syndrome in the liver. Histological analysis of the liver revealed that lipid-droplet formation and hepatocyte ballooning, which are key NAFLD characteristics, were both drastically decreased in cranberry-supplemented-HFD-fed mice relative to the levels in HFD-fed control mice. Our results suggest that cranberry ameliorates HFD-induced metabolic disturbances, particularly during the early treatment stage, and exhibits considerable potential for preventing the progression of NAFLD.
C1 [Shimizu, Kahori; Imoto, Akane; Nagayama, Hideki; Tetsumura, Naho; Terada, Tomoyuki; Nishinaka, Toru] Osaka Ohtani Univ, Fac Pharm, Lab Biochem, 3-11-1 Nishikiori Kita, Tondabayashi, Osaka 5848540, Japan.
   [Ono, Moe; Tomita, Koji] Osaka Ohtani Univ, Fac Pharm, Lab Mol Biol, 3-11-1 Nishikiori Kita, Tondabayashi, Osaka 5848540, Japan.
RP Shimizu, K (corresponding author), Osaka Ohtani Univ, Fac Pharm, Lab Biochem, 3-11-1 Nishikiori Kita, Tondabayashi, Osaka 5848540, Japan.
EM simizukaho@osaka-ohtani.ac.jp
RI Shimizu, Kahori/ITU-3575-2023
OI Shimizu, Kahori/0000-0003-1574-5526
FU JSPS KAKENHI [JP15K18939, JP18K14964]; Osaka Ohtani University Research
   Foundation
FX This study was supported by JSPS KAKENHI, Grant Numbers JP15K18939 and
   JP18K14964, and Osaka Ohtani University Research Foundation (K.S.).
CR Afshin A, 2017, NEW ENGL J MED, V377, P13, DOI 10.1056/NEJMoa1614362
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NR 29
TC 16
Z9 16
U1 0
U2 6
PU PHARMACEUTICAL SOC JAPAN
PI TOKYO
PA 2-12-15 SHIBUYA, SHIBUYA-KU, TOKYO, 150-0002, JAPAN
SN 0918-6158
J9 BIOL PHARM BULL
JI Biol. Pharm. Bull.
PD AUG
PY 2019
VL 42
IS 8
BP 1295
EP 1302
DI 10.1248/bpb.b18-00984
PG 8
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA IN7JZ
UT WOS:000478859000006
PM 31366865
OA gold
DA 2025-06-11
ER

PT J
AU Mohapatra, E
   Priya, R
   Nanda, R
   Patel, S
AF Mohapatra, Eli
   Priya, Ritu
   Nanda, Rachita
   Patel, Suprava
TI Serum GGT and serum ferritin as early markers for metabolic syndrome
SO JOURNAL OF FAMILY MEDICINE AND PRIMARY CARE
LA English
DT Article
DE Biomarkers; lifestyles diseases; oxidant stress
ID GAMMA-GLUTAMYL-TRANSPEPTIDASE; TRANSFERASE
AB Background: In India, the prevalence of lifestyle diseases like diabetes, hypertension, and metabolic syndrome (MetS) is showing an upward trend. Gamma glutamate transferase (GGT) and ferritin increase oxidant stress in the body through their role in glutathione homeostasis and iron metabolism, respectively. The increase in oxidant stress increases the inflammatory load, a risk factor for metabolic syndrome. These parameters are cheap, patient-friendly, and available in routine diagnostic labs compatible for follow-up, relieving the already overburdened healthcare system. Methodology: In a case-control study, samples of 77 cases of metabolic syndrome and 77 age and sex-matched controls were analyzed for serum GGT (by modified IFCC) and serum ferritin (by CLIA). Statistical analysis was done by SPSS 20.0 version. Results: The mean +/- SD for ferritin and GGT were 101.58 +/- 84.20 ng/dL and 36.67 +/- 26.40 IU/L, respectively in cases, whereas in control group these values were 38.38 +/- 29.26 ng/dL and 16.5 3 +/- 6.79 IU/L (P < 0.001). Positive and significant correlation was seen between GGT with TG (r-value- 0.376/P-value-0.001) and GGT with waist circumference (r-value- 0.298/P-value- 0.022). A positive and significant correlation was seen between GGT and ferritin in cases with an r-value of 0.307 (P-value - 0.01). Conclusion: The increased values of GGT and ferritin in cases suggest an inflammatory load. The positive and significant correlation between GGT and triglyceride indicates its role in increasing oxidants' stress leading to inflammation and the development of MetS. The association of ferritin with MetS though insignificant may be considered as a biomarker.
C1 [Mohapatra, Eli; Priya, Ritu; Nanda, Rachita; Patel, Suprava] All India Inst Med Sci, Dept Biochem, Raipur, Chhattisgarh, India.
C3 All India Institute of Medical Sciences (AIIMS) Raipur
RP Mohapatra, E (corresponding author), AIIMS Raipur, Dept Biochem, Med Coll Bldg,Gate 5,GE Rd, Raipur 492099, Chhattisgarh, India.
EM dr.e.mohapatra@aiimsraipur.edu.in
RI Priya, Ritu/AAV-7758-2020
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NR 20
TC 10
Z9 10
U1 0
U2 2
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, 400059, INDIA
SN 2249-4863
EI 2278-7135
J9 J FAM MED PRIM CARE
JI J. Fam. Med. Prim. Care
PD JUL
PY 2020
VL 9
IS 7
BP 3458
EP 3463
DI 10.4103/jfmpc.jfmpc_570_20
PG 6
WC Primary Health Care
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA RZ2OM
UT WOS:000648438400050
PM 33102313
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Karatsoreos, IN
   Bhagat, SM
   Bowles, NP
   Weil, ZM
   Pfaff, DW
   McEwen, BS
AF Karatsoreos, Ilia N.
   Bhagat, Sarah M.
   Bowles, Nicole P.
   Weil, Zachary M.
   Pfaff, Donald W.
   McEwen, Bruce S.
TI Endocrine and Physiological Changes in Response to Chronic
   Corticosterone: A Potential Model of the Metabolic Syndrome in Mouse
SO ENDOCRINOLOGY
LA English
DT Article
ID HIPPOCAMPAL CA3C NEURONS; STRESS-INDUCED ATROPHY; INSULIN-RESISTANCE;
   CUSHINGS-SYNDROME; APICAL DENDRITES; CLOCK PROTEIN; GLUCOCORTICOIDS;
   OBESITY; LEPTIN; DEXAMETHASONE
AB Numerous clinical and experimental studies have linked stress to changes in risk factors associated with the development of physiological syndromes, including metabolic disorders. How different mediators of the stress response, such as corticosterone (CORT), influence these changes in risk remains unclear. Although CORT has beneficial short-term effects, long-term CORT exposure can result in damage to the physiological systems it protects acutely. Disruption of this important physiologic signal is observed in numerous disparate disorders, ranging from depression to Cushing's syndrome. Thus, understanding the effects of chronic high CORT on metabolism and physiology is of key importance. We explored the effects of 4-wk exposure to CORT dissolved in the drinking water on the physiology and behavior of male mice. We used this approach as a noninvasive way of altering plasma CORT levels while retaining some integrity in the diurnal rhythm present in normal animals. This approach has advantages over methods involving constant CORT pellets, CORT injections, or adrenalectomy. We found that high doses of CORT (100 mu g/ml) result in rapid and dramatic increases in weight gain, increased adiposity, elevated plasma leptin, insulin and triglyceride levels, hyperphagia, and decreased home-cage locomotion. A lower dose of CORT (25 mu g/ml) resulted in an intermediate phenotype in some of these measures but had no effect on others. We propose that the physiological changes observed in the high-CORT animals approximate changes observed in individuals suffering from the metabolic syndrome, and that they potentially serve as a model for hypercortisolemia and stress-related obesity. (Endocrinology 151: 2117-2127, 2010)
C1 [Karatsoreos, Ilia N.; Bhagat, Sarah M.; Bowles, Nicole P.; Weil, Zachary M.; McEwen, Bruce S.] Rockefeller Univ, Neuroendocrinol Lab, New York, NY 10065 USA.
   [Weil, Zachary M.; Pfaff, Donald W.] Rockefeller Univ, Neurobiol & Behav Lab, New York, NY 10065 USA.
C3 Rockefeller University; Rockefeller University
RP Karatsoreos, IN (corresponding author), Rockefeller Univ, Neuroendocrinol Lab, Box 165,1230 York Ave, New York, NY 10065 USA.
EM ikaratsore@rockefeller.edu
RI Weil, Zachary/A-2439-2008; Karatsoreos, Ilia/AAR-8774-2020; McEwen,
   Bruce/Z-1630-2019
OI Weil, Zachary/0000-0003-3758-1809; Bhagat, Sarah M/0000-0003-1108-6244
FU Canadian Institutes for Health Research postdoctoral fellowship;
   National Institutes of Health [5RO1 MH41256]; Depression Research
   Foundation; Sepracor, Inc
FX This work was supported by a Canadian Institutes for Health Research
   postdoctoral fellowship (I.N.K.) and by the National Institutes of
   Health Grant 5RO1 MH41256 (to B.S.M.). B.S.M. was also supported by the
   Hope for Depression Research Foundation and by Sepracor, Inc.
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NR 48
TC 211
Z9 229
U1 0
U2 27
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0013-7227
EI 1945-7170
J9 ENDOCRINOLOGY
JI Endocrinology
PD MAY
PY 2010
VL 151
IS 5
BP 2117
EP 2127
DI 10.1210/en.2009-1436
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 586JF
UT WOS:000276902600018
PM 20211972
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Ahdout, J
   Kotlerman, J
   Elashoff, D
   Kim, J
   Chiu, MW
AF Ahdout, J.
   Kotlerman, J.
   Elashoff, D.
   Kim, J.
   Chiu, M. W.
TI Modifiable lifestyle factors associated with metabolic syndrome in
   patients with psoriasis
SO CLINICAL AND EXPERIMENTAL DERMATOLOGY
LA English
DT Article
ID PREVALENCE; DISEASE; RISK; EPIDEMIOLOGY; OBESITY; SMOKING; DIET
AB Background. Psoriasis is a chronic inflammatory skin disease, which is associated with obesity and with cardiovascular morbidity and mortality. Aim. To evaluate modifiable lifestyle factors including stress level, physical activity and nutrition, which may be associated with metabolic syndrome in patients with psoriasis. Methods. In total, 65 patients with psoriasis and 52 control subjects from our university dermatology clinic were enrolled in this casecontrol pilot study. The study questionnaire included the Perceived Stress Scale (PSS), the Godin Leisure-Time Exercise Questionnaire (GLTEQ) and the Rapid Eating Assessment for patients (REAP). For subjects with psoriasis, the Psoriasis Area and Severity Index (PASI) was measured. Results. Subjects with psoriasis (mean BMI 27.72) displayed a trend towards a higher BMI compared with controls (mean BMI 25.67). Subjects with psoriasis were not found to have an increased prevalence of self-reported metabolic syndrome-associated diseases including diabetes, heart disease, high cholesterol, hypertension or stroke compared with controls (P = 0.25, P = 0.46, P = 0.96, P = 0.26, and P = 0.16, respectively). There was no significant difference in exercise or stress between patients with psoriasis and controls (P = 0.06 and P = 0.26, respectively). However, compared with controls, subjects with psoriasis (mean REAP score = 2.23) did report poorer overall nutrition as assessed by the REAP score (mean = 2.38, P < 0.01). Among subjects with psoriasis, the factors of stress, smoking and systemic therapy were associated with increased PASI (r = 0.13, r = 3.47 and r = 3.19, respectively). Conclusions. Our study suggests that poor dietary and exercise habits may be factors contributing to obesity and metabolic syndrome in patients with psoriasis. Further studies with larger numbers are needed to confirm these results.
C1 [Ahdout, J.] Univ Calif Irvine, Dept Dermatol, Irvine, CA 92697 USA.
   [Kotlerman, J.; Elashoff, D.] Univ Calif Los Angeles, David Geffen Sch Med, Dept Med Stat Core, Los Angeles, CA 90095 USA.
   [Kim, J.; Chiu, M. W.] Univ Calif Los Angeles, David Geffen Sch Med, Div Dermatol, Dept Med, Los Angeles, CA 90095 USA.
   [Kim, J.; Chiu, M. W.] Greater Los Angeles Vet Affairs Healthcare Syst, Dermatol Serv, Los Angeles, CA USA.
C3 University of California System; University of California Irvine;
   University of California System; University of California Los Angeles;
   University of California Los Angeles Medical Center; David Geffen School
   of Medicine at UCLA; University of California System; University of
   California Los Angeles; University of California Los Angeles Medical
   Center; David Geffen School of Medicine at UCLA; US Department of
   Veterans Affairs; Veterans Health Administration (VHA); VA Greater Los
   Angeles Healthcare System
RP Ahdout, J (corresponding author), Univ Calif Irvine, Dept Dermatol, C340 Med Sci 1, Irvine, CA 92697 USA.
EM jahdout@gmail.com
FU UCLA Department of Medicine, Division of Dermatology; Dermatologic
   Research Foundation of California
FX This study was supported in part by the UCLA Department of Medicine,
   Division of Dermatology and the Dermatologic Research Foundation of
   California. The sponsors had no role in the design and conduct of the
   study, the collection, analysis and interpretation of the data, or in
   the preparation, review or approval of the manuscript.
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NR 25
TC 27
Z9 30
U1 0
U2 9
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0307-6938
EI 1365-2230
J9 CLIN EXP DERMATOL
JI Clin. Exp. Dermatol.
PD JUL
PY 2012
VL 37
IS 5
BP 477
EP 483
DI 10.1111/j.1365-2230.2012.04360.x
PG 7
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 961ZX
UT WOS:000305509800003
PM 22712856
DA 2025-06-11
ER

PT J
AU Rossi, MM
   Signorini, FJ
   Castillo, TA
   Parada, MPS
   Moser, F
   Baez, MD
AF Rossi, Micaela M.
   Signorini, Franco J.
   Castillo, Tomas A.
   Parada, Maria P. Scribano
   Moser, Federico
   Baez, Maria dC
TI Sleeve Gastrectomy Reduces Oxidative Stress and Reverses Mitochondrial
   Dysfunction Associated with Metabolic Syndrome
SO OBESITY SURGERY
LA English
DT Article; Early Access
DE Sleeve gastrectomy; Oxidative stress; Mitochondrial dysfunction;
   Metabolic syndrome
ID BARIATRIC SURGERY; NITRIC-OXIDE; RESPIRATION; SUPEROXIDE; OBESITY; RISK
AB IntroductionPrevious studies have detected mitochondrial alterations in tissues of individuals with obesity and type 2 diabetes mellitus (T2DM). Metabolic surgery could be an effective treatment to improve mitochondrial morphology and reduce oxidative stress (OS).MethodsAn experimental study was carried out using 48 male Wistar rats, divided into 6 groups (n = 8): control (C), induced Metabolic Syndrome (MS); intervention with sleeve gastrectomy (SG), MS + SG with 6 weeks postoperatively (MS + SG6), MS + SG with 12 weeks postoperatively (MS + SG12), and MS + SG with 24 weeks postoperatively (MS + SG24). Biochemical markers indicative of MS (glycemia, cholesterol, and triglyceride levels) and oxidative stress markers (nitric oxide levels, Superoxide dismutase and Myeloperoxidase activity) were determined. To study mitochondrial morphology, tissue sections of the thoracic aorta, stomach, liver, heart, and kidney were observed by electron microscopy.ResultsMS group exhibited elevated glycemic values and dyslipidemia. SG and MS + SG groups showed improvements in glycemia and lipid profiles compared to MS. OS biomarkers indicated reduced oxidative stress in SG and MS + SG groups compared to MS. Electron microscopy revealed mitochondrial alterations in MS. SG group showed no changes compared to the control. MS + SG6 and MS + SG12 groups showed a recovery of mitochondrial morphology until reaching images similar to the control in MS + SG24.ConclusionMetabolic surgery could improve mitochondrial function by restoring mitochondrial morphology and architecture and, consequently, reducing systemic oxidative stress and remitting associated metabolic alterations.
C1 [Rossi, Micaela M.; Signorini, Franco J.; Castillo, Tomas A.; Parada, Maria P. Scribano; Baez, Maria dC] Natl Univ Cordoba, Fac Med Sci, Biomed Phys Dept, RA-1085 Santa Rosa, Cordoba Capital, Argentina.
   [Rossi, Micaela M.; Signorini, Franco J.; Moser, Federico] Hosp Privado Univ Cordoba, Gen Surg Dept, Bariatr Surg Program, Ave Nac Unidas 346, RA-5016 Cordoba Capital, Argentina.
C3 National University of Cordoba; Hospital Privado - Universitario de
   Cordoba
RP Rossi, MM (corresponding author), Natl Univ Cordoba, Fac Med Sci, Biomed Phys Dept, RA-1085 Santa Rosa, Cordoba Capital, Argentina.; Rossi, MM (corresponding author), Hosp Privado Univ Cordoba, Gen Surg Dept, Bariatr Surg Program, Ave Nac Unidas 346, RA-5016 Cordoba Capital, Argentina.
EM micarossi1997@gmail.com; fransign@hotmail.com;
   tomasaugustocastillo@unc.edu.ar; pazscribano@unc.edu.ar;
   fedemoser@hotmail.com; maria.baez@unc.edu.ar
OI rossi, micaela/0009-0000-4986-4844
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NR 34
TC 2
Z9 2
U1 1
U2 2
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0960-8923
EI 1708-0428
J9 OBES SURG
JI Obes. Surg.
PD 2024 APR 24
PY 2024
DI 10.1007/s11695-024-07244-y
EA APR 2024
PG 12
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA OK1R5
UT WOS:001207078300001
PM 38653888
DA 2025-06-11
ER

PT J
AU Zurawska-Plaksej, E
   Grzebyk, E
   Marciniak, D
   Szymanska-Chabowska, A
   Piwowar, A
AF Zurawska-Plaksej, E.
   Grzebyk, E.
   Marciniak, D.
   Szymanska-Chabowska, A.
   Piwowar, A.
TI Oxidatively modified forms of albumin in patients with risk factors of
   metabolic syndrome
SO JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
LA English
DT Article
DE Metabolic syndrome; Advanced oxidation protein products; Ischemia
   modified albumin; Oxidative stress; Serum albumin modifications
ID ISCHEMIA-MODIFIED ALBUMIN; PROTEIN OXIDATION; STRESS; INFLAMMATION;
   ASSOCIATION; PRODUCTS; MARKERS; COMPONENTS; BIOMARKER; DISEASES
AB Background Metabolic syndrome (MetS) is a complex metabolic disease connected especially with lipid and carbohydrate disturbances. It is postulated that oxidative stress (OS) is linked to metabolic syndrome, constituting a novel component of its pathogenesis.
   Aim We aimed to examine the plasma level of oxidatively modified proteins-advanced oxidation protein products (AOPP) and ischemia modified albumin (IMA)-as well as thiol (SH) groups and evaluate their connection with metabolic agents in relation to MetS prevalence.
   Subjects and methods The levels of AOPP, IMA and SH groups were measured spectrophotometrically in 106 patients with MetS risk factors and in 32 control subjects.
   Results The levels of examined parameters differed significantly between patients with MetS risk factors and the control group. AOPP significantly correlated with glucose (r = 0.30, p = 0.008), HDL-Ch (r = -0.34, p = 0.005), TG (r = 0.48, p < 0.001) and fibrinogen (r = 0.37, p < 0.001). The levels of AOPP and IMA increased progressively with the number of MetS risk factors, being the most significant for AOPP. The highest values of AOPP were associated with the presence of at least three risk factors. Only AOPP were an independent determinant for MetS occurrence in the studied population (OR = 2.72, p = 0.04). Mutual dependence between metabolic, oxidative stress and inflammatory parameters was revealed.
   Conclusions Oxidative modifications of proteins are increased in MetS and accumulation of MetS risk factors enhances manifestation of OS. AOPP is the most appropriate parameter for determination of OS, with potential diagnostic value in MetS patients.
C1 [Zurawska-Plaksej, E.; Grzebyk, E.; Piwowar, A.] Wroclaw Med Univ, Fac Pharm, Dept Pharmaceut Biochem, PL-50556 Wroclaw, Poland.
   [Marciniak, D.] Wroclaw Med Univ, Fac Pharm, Dept Drugs Form Technol, PL-50556 Wroclaw, Poland.
   [Szymanska-Chabowska, A.] Wroclaw Med Univ, Fac Med, Dept & Clin Internal & Occupat Dis & Hypertens, PL-50556 Wroclaw, Poland.
C3 Wroclaw Medical University; Wroclaw Medical University; Wroclaw Medical
   University
RP Piwowar, A (corresponding author), Wroclaw Med Univ, Fac Pharm, Dept Pharmaceut Biochem, Borowska St 211A, PL-50556 Wroclaw, Poland.
EM agnieszka.piwowar@umed.wroc.pl
RI Zurawska-Plaksej, Ewa/HKW-0666-2023; Marciniak, Dominik M./U-4348-2018
OI Grzebyk, Ewa/0000-0002-4872-3756; Piwowar,
   Agnieszka/0000-0001-6971-3883; Szymanska-Chabowska,
   Anna/0000-0003-3615-6923; Zurawska-Plaksej, Ewa/0000-0001-8566-3943;
   Marciniak, Dominik M./0000-0002-3326-0840
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NR 41
TC 41
Z9 42
U1 0
U2 3
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0391-4097
EI 1720-8386
J9 J ENDOCRINOL INVEST
JI J. Endocrinol. Invest.
PD SEP
PY 2014
VL 37
IS 9
BP 819
EP 827
DI 10.1007/s40618-014-0111-8
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA AP4QR
UT WOS:000342063500006
PM 24957167
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Bateni, Z
   Behrouz, V
   Rahim, HR
   Hedayati, M
   Afsharian, S
   Sohrab, G
AF Bateni, Zohreh
   Behrouz, Vahideh
   Rahim, Hamid RezA
   Hedayati, Mehdi
   Afsharian, Shila
   Sohrab, Golbon
TI Effects of nano-curcumin supplementation on oxidative stress, systemic
   inflammation, adiponectin, and NF-κB in patients with metabolic
   syndrome: A randomized, double-blind clinical trial
SO JOURNAL OF HERBAL MEDICINE
LA English
DT Article
DE Metabolic syndrome; Nano-curcumin; Oxidative stress; Inflammation;
   Adiponectin
ID LIPID PROFILE
AB Background: Oxidative stress and inflammation are known to play a central pathophysiological role in the development and clinical expression of metabolic syndrome (MetS). Curcumin, a yellow polyphenolic compound extracted from turmeric, has been found to have antioxidant and anti-inflammatory activities. The present study aimed to evaluate the effects of nano-micelle curcumin on oxidative stress, systemic inflammation, adiponectin, and nuclear factor-kappa B (NF-kappa B) in patients with MetS.Methods: In this randomized, double-blind, clinical trial, 50 patients with metabolic syndrome were randomly assigned into the nano-micelle curcumin and the placebo groups to receive either 80 mg/day nano-curcumin or placebo for 12 weeks.Results: The mean malondialdehyde (MDA) level decreased in the nano-micelle curcumin group compared to the baseline (8.07 & PLUSMN; 3.14 vs. 6.39 & PLUSMN; 2.11; p < 0.05). Also, the mean adiponectin level improved in the nano-micelle curcumin group (2.62 & PLUSMN; 0.13 vs. 2.96 & PLUSMN; 0.15; p < 0.05). Total antioxidant capacity (TAC) increased significantly in both arms of the study. However, there were no significant differences between the two groups for MDA, TAC, and adiponectin after the intervention. There were no significant differences in other parameters, including high sensitive-C reactive protein (hs-CRP) and NF-kB within and between groups.Conclusion: A 12-week supplementation with 80 mg/day nano-micelle curcumin could improve MDA, TAC, and adiponectin within nano-micelle curcumin, but it had no significant effects on hs-CRP and NF-kappa B within and between groups.
C1 [Bateni, Zohreh; Sohrab, Golbon] Shahid Beheshti Univ Med Sci, Natl Nutr & Food Technol Res Inst, Fac Nutr Sci & Food Technol, Dept Clin Nutr & Dietet, Tehran, Iran.
   [Behrouz, Vahideh] Kerman Univ Med Sci, Fac Publ Hlth, Dept Nutr, Kerman, Iran.
   [Rahim, Hamid RezA] Mashhad Univ Med Sci, Fac Med, Dept Modern Sci & Technol, Mashhad, Razavi Khorasan, Iran.
   [Hedayati, Mehdi] Shahid Beheshti Univ Med Sci, Res Inst Endocrine Sci, Cellular & Mol Res Ctr, Tehran, Iran.
   [Afsharian, Shila] Shahid Beheshti Univ Med Sci, Res Inst Endocrine Sci, Prevent Metab Disorders Res Ctr, Tehran, Iran.
C3 Shahid Beheshti University Medical Sciences; Kerman University of
   Medical Sciences; Mashhad University of Medical Sciences; Shahid
   Beheshti University Medical Sciences; Shahid Beheshti University Medical
   Sciences
RP Sohrab, G (corresponding author), Shahid Beheshti Univ Med Sci, Natl Nutr & Food Technol Res Inst, Fac Nutr Sci & Food Technol, Dept Clin Nutr & Dietet, Tehran, Iran.
EM golbonsohrab@sbmu.ac.ir; golbonsohrab@sbmu.ac.ir
RI Sohrab, Golbon/AHE-4922-2022; Hedayati, Mehdi/AAG-3006-2019; behrouz,
   vahideh/AAL-5105-2020
FU National Nutrition and Food Technology Research Institute, Shahid
   Beheshti University of Medical Sciences
FX The present study was supported by the grant from National Nutrition and
   Food Technology Research Institute, Shahid Beheshti University of
   Medical Sciences. The role of the funding body was in the design of the
   study, data collection, analysis, and interpretation of data.
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NR 35
TC 21
Z9 22
U1 0
U2 2
PU ELSEVIER GMBH
PI MUNICH
PA HACKERBRUCKE 6, 80335 MUNICH, GERMANY
SN 2210-8033
EI 2210-8041
J9 J HERB MED
JI J. Herb. Med.
PD FEB
PY 2022
VL 31
AR 100531
DI 10.1016/j.hermed.2021.100531
EA JAN 2022
PG 7
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA 0G0TV
UT WOS:000777768200008
DA 2025-06-11
ER

PT J
AU Ziegler, MG
   Elayan, H
   Milic, M
   Sun, P
   Gharaibeh, M
AF Ziegler, Michael G.
   Elayan, Hamzeh
   Milic, Milos
   Sun, Ping
   Gharaibeh, Munir
TI Epinephrine and the Metabolic Syndrome
SO CURRENT HYPERTENSION REPORTS
LA English
DT Article
DE Epinephrine; Metabolic syndrome; Norepinephrine; Insulin; Beta
   adrenergic receptors; Hypertension; Blood pressure; Obesity; Exercise;
   Glucose; Diabetes; Stress
ID SYMPATHETIC NERVOUS-SYSTEM; INDUCED INSULIN-RESISTANCE; STIMULATED
   GLUCOSE-UPTAKE; ACTIVATED PROTEIN-KINASE; SKELETAL-MUSCLE;
   PHYSICAL-ACTIVITY; ELDERLY MEN; BODY-WEIGHT; EXERCISE; OBESITY
AB Epinephrine is the prototypical stress hormone. Its stimulation of all alpha and beta adrenergic receptors elicits short-term systolic hypertension, hyperglycemia, and other aspects of the metabolic syndrome. Acute epinephrine infusion increases cardiac output and induces insulin resistance, but removal of the adrenal medulla has no consistent effect on blood pressure. Epinephrine is the most effective endogenous agonist at the beta 2 receptor. Transgenic mice that cannot make epinephrine and mice that lack the beta 2 receptor become hypertensive during exercise, presumably owing to the absence of beta 2-mediated vasodilatation. Epinephrine-deficient mice also have cardiac remodeling and poor cardiac responses to stress, but do not develop resting hypertension. Mice that cannot make epinephrine have a normal metabolism on a regular 14% fat diet but become hyperglycemic and insulin resistant when they eat a high fat diet. Vigorous exercise prevents diabetes in young mice and humans that overeat. However, exercise is a less effective treatment in older type 2 human diabetics and had no effect on glucose or insulin responses in older, diabetic mice. Sensitivity of the beta 2 receptor falls sharply with advancing age, and adrenal epinephrine release also decreases. However, treatment of older diabetic mice with a beta 2 adrenergic agonist improved insulin sensitivity, indicating that beta 2 subsensitivity can be overcome pharmacologically. Recent studies show that over the long term, epinephrine prevents hypertension during stress and improves glucose tolerance. The hyperglycemic influence of epinephrine is short-lived. Chronic administration of epinephrine and other beta 2 agonists improves cellular glucose uptake and metabolism. Overall, epinephrine counteracts the metabolic syndrome.
C1 [Ziegler, Michael G.] UCSD Med Ctr, San Diego, CA 92103 USA.
   [Elayan, Hamzeh; Gharaibeh, Munir] Univ Jordan, Dept Pharmacol, Amman, Jordan.
   [Milic, Milos; Sun, Ping] Univ Calif San Diego, San Diego, CA 92103 USA.
C3 University of California System; University of California San Diego;
   University of Jordan; University of California System; University of
   California San Diego
RP Ziegler, MG (corresponding author), UCSD Med Ctr, 200 W Arbor Dr, San Diego, CA 92103 USA.
EM mziegler@ucsd.edu
RI Ziegler, Michael/L-4728-2019
FU NIH [HL58120, M01RR00827, 1UL1RR0319800]
FX This work was supported by NIH grants HL58120, M01RR00827, and
   1UL1RR0319800.
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NR 53
TC 56
Z9 64
U1 0
U2 22
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1522-6417
J9 CURR HYPERTENS REP
JI Curr. Hypertens. Rep.
PD FEB
PY 2012
VL 14
IS 1
BP 1
EP 7
DI 10.1007/s11906-011-0243-6
PG 7
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 874ZC
UT WOS:000298996500001
PM 22124970
DA 2025-06-11
ER

PT J
AU McElroy, SL
   Keck, PE
AF McElroy, Susan L.
   Keck, Paul E., Jr.
TI Metabolic Syndrome in Bipolar Disorder: A Review With a Focus on Bipolar
   Depression
SO JOURNAL OF CLINICAL PSYCHIATRY
LA English
DT Review
ID C-REACTIVE PROTEIN; ANTIPSYCHOTIC-DRUG TREATMENT; CARDIOVASCULAR
   RISK-FACTORS; WEEKLY SYMPTOMATIC STATUS; OBSTRUCTIVE SLEEP-APNEA; 3RD
   NATIONAL-HEALTH; INSULIN-RESISTANCE; MOOD DISORDERS; BLOOD-PRESSURE;
   PHYSICAL-ACTIVITY
AB Objective: To perform a detailed, qualitative review of existing literature on the co-occurrence of bipolar disorder and metabolic syndrome, the impact of metabolic dysregulation on patients with bipolar disorder, and treatment considerations, with a focus on bipolar depression.
   Data Sources: Searches of the PubMed database (October 23, 2012) and Cochrane Library (September 20, 2013) were conducted for English-language articles published from January 1980 onward containing the keywords bipolar AND metabolic, weight, obesity, diabetes, dyslipidemia, OR hypertension in the title or abstract. The searches yielded 1,817 citations from which case reports, conference abstracts, and pediatric studies were excluded.
   Study Selection: Abstracts and titles were evaluated for relevance to the stated objectives. Full texts of 176 articles were obtained for further evaluation; additional articles were identified from reference lists.
   Results: Metabolic risk factors are highly prevalent yet undertreated in patients with bipolar disorder. Putative factors accounting for the link between bipolar disorder and metabolic syndrome include behavioral/phenomenological features, shared neurobiologic abnormalities, and adverse effects of psychotropic medications. A comprehensive assessment of metabolic risk and regular monitoring of body mass index, waist circumference, lipid profile, and plasma glucose are important for patients with bipolar disorder. Management strategies for the bipolar patient with metabolic risk factors include use of bipolar disorder medications with better metabolic profiles, lifestyle interventions, and adjunctive pharmacotherapy for dyslipidemia, hypertension, and/or hyperglycemia.
   Conclusions: Adequate management of metabolic syndrome may improve clinical outcomes in patients with bipolar disorder, as well as prevent adverse cardiovascular events and the development of diabetes. (C) Copyright 2014 Physicians Postgraduate Press, Inc.
C1 [McElroy, Susan L.] Lindner Ctr HOPE, Mason, OH 45050 USA.
   Univ Cincinnati, Coll Med, Dept Psychiat & Behav Neurosci, Cincinnati, OH USA.
C3 University System of Ohio; University of Cincinnati
RP McElroy, SL (corresponding author), Lindner Ctr HOPE, 4075 Old Western Row Rd, Mason, OH 45050 USA.
EM susan.mcelroy@lindnercenter.org
FU Teva Pharmaceuticals, North Wales, Pennsylvania
FX Funding for technical editorial and medical writing support was provided
   by Teva Pharmaceuticals, North Wales, Pennsylvania. A medical accuracy
   review of the final draft for submission was also provided by Teva
   Pharmaceuticals.
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NR 218
TC 78
Z9 86
U1 0
U2 44
PU PHYSICIANS POSTGRADUATE PRESS
PI MEMPHIS
PA P O BOX 752870, MEMPHIS, TN 38175-2870 USA
SN 0160-6689
EI 1555-2101
J9 J CLIN PSYCHIAT
JI J. Clin. Psychiatry
PY 2014
VL 75
IS 1
BP 46
EP 61
DI 10.4088/JCP.13r08634
PG 16
WC Psychology, Clinical; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA AA0FO
UT WOS:000330771200009
PM 24922490
DA 2025-06-11
ER

PT J
AU Camargo, A
   Range-Zúñiga, OA
   Peña-Orihuela, P
   Marín, C
   Pérez-Martínez, P
   Delgado-Lista, J
   Gutierrez-Mariscal, FM
   Malagón, MM
   Roche, HM
   Tinahones, FJ
   Perez-Jimenez, F
   Lopez-Miranda, J
AF Camargo, Antonio
   Alberto Range-Zuniga, Oriol
   Pena-Orihuela, Patricia
   Marin, Carmen
   Perez-Martinez, Pablo
   Delgado-Lista, Javier
   Miguel Gutierrez-Mariscal, Francisco
   Malagon, Maria M.
   Roche, Helen M.
   Jose Tinahones, Francisco
   Perez-Jimenez, Francisco
   Lopez-Miranda, Jose
TI Postprandial changes in the proteome are modulated by dietary fat in
   patients with metabolic syndrome
SO JOURNAL OF NUTRITIONAL BIOCHEMISTRY
LA English
DT Article
DE Proteomic; Diet; Oxidative stress; Atherothrombosis; Metabolic syndrome
ID BLOOD MONONUCLEAR-CELLS; GENE-EXPRESSION PROFILES; ACTIVATED
   RECEPTOR-ALPHA; ENDOPLASMIC-RETICULUM; OXIDATIVE STRESS; BETA-OXIDATION;
   INFLAMMATION; P53; DISEASE; ACIDS
AB Metabolic syndrome is a multicomponent disorder whose etiology is the result of a complex interaction between genetic, metabolic and environmental factors including dietary habits. Our aim was to identify proteome-diet interactions during the postprandial state after the acute intake of four meals with different qualities of fat in the proteome of peripheral blood mononuclear cells. A randomized controlled trial conducted within the LIPGENE study assigned 39 metabolic syndrome patients to one of four meals: a high-saturated-fatty-acid (HSFA) meal, a high-monounsaturated-fatty-acid (HMUFA) meal and two high-polyunsaturated-fatty-acid (from walnut) (HPUFA) meals supplemented with n-3 PUFA or placebo. We analyzed the postprandial changes in the whole proteome of both nuclear and cytoplasmic fractions of peripheral blood mononuclear cells by two-dimensional proteomics. Twenty-three proteins were differentially expressed. HSFA intake caused the postprandial increase of proteins responding to oxidative stress (HSPA1A,PDIA3 and PSME1) and DNA damage (SMC6), whereas HMUFA intake led to the up-regulation of HSPA1A and PDIA3. HPUFA meal supplementation with n-3 PUFA produced peroxisomal beta-oxidation inhibition by down-regulation of ECH1, a process related to insulin signaling improvement. In conclusion, HSFA meal intake causes deleterious postprandial changes in the proteome in terms of DNA damage and procoagulant state, which reflect a higher postprandial oxidative stress after HSFA meal intake as compared to intake of HMUFA and HPUFA meals. Moreover, the addition of long-chain n-3 PUFA to an HPUFA meal may improve insulin signaling and exerts an anti-inflammatory effect when compared to an HPUFA meal. (c) 2013 Elsevier Inc. All rights reserved.
C1 [Camargo, Antonio; Alberto Range-Zuniga, Oriol; Pena-Orihuela, Patricia; Marin, Carmen; Perez-Martinez, Pablo; Delgado-Lista, Javier; Miguel Gutierrez-Mariscal, Francisco; Perez-Jimenez, Francisco; Lopez-Miranda, Jose] Univ Cordoba, Lipids & Atherosclerosis Res Unit, IMIBIC, Reina Sofia Univ Hosp, E-14004 Cordoba, Spain.
   [Camargo, Antonio; Alberto Range-Zuniga, Oriol; Pena-Orihuela, Patricia; Marin, Carmen; Perez-Martinez, Pablo; Delgado-Lista, Javier; Miguel Gutierrez-Mariscal, Francisco; Perez-Jimenez, Francisco; Lopez-Miranda, Jose] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr CIBEROBN, Cordoba 14004, Spain.
   [Malagon, Maria M.] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr CIBEROBN, Cordoba 14014, Spain.
   [Malagon, Maria M.] Univ Cordoba, Dept Cell Biol Physiol & Immunol, IMIBIC, Cordoba 14014, Spain.
   [Roche, Helen M.] Univ Coll Dublin, UCD Conway Inst, UCD Sch Publ Hlth & Populat Sci, Nutrigen Res Grp, Dublin 4, Ireland.
   [Jose Tinahones, Francisco] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr, Malaga, Spain.
   [Jose Tinahones, Francisco] Hosp Virgen Victoria, Malaga, Spain.
C3 Universidad de Cordoba; Instituto de Salud Carlos III; CIBER - Centro de
   Investigacion Biomedica en Red; CIBEROBN; Instituto de Salud Carlos III;
   CIBER - Centro de Investigacion Biomedica en Red; CIBEROBN; Universidad
   de Cordoba; University College Dublin; CIBER - Centro de Investigacion
   Biomedica en Red; CIBEROBN; Instituto de Salud Carlos III; Hospital
   Virgen de la Victoria
RP Lopez-Miranda, J (corresponding author), Univ Cordoba, Lipids & Atherosclerosis Res Unit, IMIBIC, Reina Sofia Univ Hosp, E-14004 Cordoba, Spain.
EM jlopezmir@uco.es
RI Mariscal, Francisco/AAH-3689-2020; Lopez-Miranda, Jose/Y-8306-2019;
   Tinahones, Francisco/AAB-2882-2020; Marin Hinojosa,
   Carmen/AFO-1294-2022; Roche, Helen/AAF-4164-2019; Jimenez,
   Francisco/AAJ-9559-2021; Delgado-Lista, Javier/KAM-7412-2024; Gutierrez
   Mariscal, Francisco Miguel/F-9804-2016; Camargo Garcia,
   Antonio/G-9720-2015; Perez Martinez, Pablo/AEL-6176-2022; MALAGON, MARIA
   M/L-5386-2014
OI Pena Orihuela, Patricia J/0009-0009-9970-043X; Tinahones, Francisco
   J/0000-0001-6871-4403; Gutierrez Mariscal, Francisco
   Miguel/0000-0003-3353-2188; Camargo Garcia, Antonio/0000-0002-0415-4184;
   Perez-Jimenez, Francisco/0000-0001-7499-7681; Perez Martinez,
   Pablo/0000-0001-7716-8117; Delgado Lista, Francisco
   Javier/0000-0002-2982-2716; MALAGON, MARIA M/0000-0002-2419-2727;
   Lopez-Miranda, Jose/0000-0002-8844-0718; Rangel-Zuniga, Oriol
   Alberto/0000-0003-3495-5705; Perez Jimenez,
   Francisco/0000-0001-9808-1280; Roche, Helen/0000-0002-0628-3318
FU Spanish Ministry of Science and Innovation [AGL 2004-07907,
   AGL2006-01979, AGL2009-12270, SAF07-62005, FIS PI10/01041, PI10/02412];
   Consejeria de Economia, Innovacion y Ciencia, Proyectos de Investigacion
   de Excelencia, Junta de Andalucia [P06-CTS-01425, CTS5015, AGR922,
   CTS-03039]; Consejeria de Salud, Junta de Andalucia [06/128, 07/43,
   PI0193/09, 06/129, 06/127, 0118/08, PI-0252/09, PI-0058/10]; Fondo
   Europeo de Desarrollo Regional (FEDER); Science Foundation Ireland PI
   Programme [06/IM.1/B105]; EU Sixth Framework Food Safety & Quality
   Programme [FOOD-2003-CT-505944]
FX This research has been funded partly by research grants from the Spanish
   Ministry of Science and Innovation (AGL 2004-07907, AGL2006-01979 and
   AGL2009-12270 to J.L.-M.; SAF07-62005 to F.P.-J.; FIS PI10/01041 to
   P.P.-M.; PI10/02412 to F.P.-J.); Consejeria de Economia, Innovacion y
   Ciencia, Proyectos de Investigacion de Excelencia, Junta de Andalucia
   (P06-CTS-01425 to J.L.-M., CTS5015 and AGR922 to F.P.-J., CTS-03039 to
   M.M.M.); Consejeria de Salud, Junta de Andalucia (06/128, 07/43 and
   PI0193/09 to J.L.-M.; 06/129 to F.P.-J.; 06/127 to C.M.-H., 0118/08 to
   F.P.-J., PI-0252/09 to J.D.-L, PI-0058/10 to P.P.-M.); Fondo Europeo de
   Desarrollo Regional (FEDER); Science Foundation Ireland PI Programme
   (06/IM.1/B105) to H.M.R.; EU Sixth Framework Food Safety & Quality
   Programme (Contract Number FOOD-2003-CT-505944).
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NR 53
TC 28
Z9 35
U1 0
U2 19
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0955-2863
EI 1873-4847
J9 J NUTR BIOCHEM
JI J. Nutr. Biochem.
PD JAN
PY 2013
VL 24
IS 1
BP 318
EP 324
DI 10.1016/j.jnutbio.2012.06.014
PG 7
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA 056HT
UT WOS:000312479700039
PM 22959058
DA 2025-06-11
ER

PT J
AU Kagota, S
   Fukushima, K
   Umetani, K
   Tada, Y
   Nejime, N
   Nakamura, K
   Mori, H
   Sugimura, K
   Kunitomo, M
   Shinozuka, K
AF Kagota, Satomi
   Fukushima, Kazuhito
   Umetani, Keiji
   Tada, Yukari
   Nejime, Namie
   Nakamura, Kazuki
   Mori, Hidezo
   Sugimura, Kazuro
   Kunitomo, Masaru
   Shinozuka, Kazumasa
TI Coronary vascular dysfunction promoted by oxidative-nitrative stress in
   SHRSP.Z-Leprfa/IzmDmcr rats with metabolic syndrome
SO CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
LA English
DT Article
DE angiotensin II; coronary artery; metabolic syndrome; nitric oxide;
   oxidative-nitrative stress
ID SHR/NDMCR-CP RATS; ZUCKER OBESE RATS; ENDOTHELIAL DYSFUNCTION;
   NITRIC-OXIDE; ANIMAL-MODEL; PEROXYNITRITE; HYPERTENSION; ARTERIES;
   VASORELAXATION; INFLAMMATION
AB P>1. Metabolic syndrome is an independent risk factor for cardiovascular disease. SHRSP.Z-Leprfa/IzmDmcr (SHRSP fatty) rat, established as a new rat model of metabolic syndrome, spontaneously develops obesity, severe hypertension and shows hypertriglyceridaemia, hypercholesterolaemia and abnormal glucose tolerance. Using SHRSP fatty rats, we examined whether or not oxidative stress was correlated with vascular dysfunction in small and large calibre coronary arteries in ex vivo beating hearts, isolated mesenteric arteries and aortas in comparison with normal rats, Wistar-Kyoto rats (WKY). Vasodilation of coronary arteries was determined by microangiography of the Langendorff heart.
   2. Compared with WKY, acetylcholine (ACh) and sodium nitroprusside (SNP)-induced relaxations were impaired in the coronary arteries of SHRSP fatty rats. The mesenteric arteries and aorta of SHRSP fatty rats showed impaired relaxation responses to ACh and SNP, decreased 3',5'-monophosphate (cGMP) production, and reduced soluble guanylyl cyclase protein expression. Superoxide release, angiotensin II and 3-nitrotyrosine contents were increased.
   3. SHRSP fatty rats were orally administered olmesartan, an angiotensin II receptor type 1 (AT(1)) antagonist, and amlodipine, a calcium channel blocker, at doses of 5 and 8 mg/kg per day, respectively, for 8 weeks. Both olmesartan and amlodipine reduced blood pressure, but only olmesartan prevented the development of abnormal vascular and biochemical parameters in the SHRSP fatty rats.
   4. The results showed that in the SHRSP fatty rats, the impaired nitric oxide- and cGMP-mediated relaxation of vascular smooth muscle cells were linked to AT(1) receptor-induced oxidative-nitrative stress, which occurred concurrently with severe hypertension and metabolic abnormalities in vivo.
C1 [Kagota, Satomi; Tada, Yukari; Nejime, Namie; Nakamura, Kazuki; Kunitomo, Masaru; Shinozuka, Kazumasa] Mukogawa Womens Univ, Sch Pharm & Pharmaceut Sci, Dept Pharmacol, Nishinomiya, Hyogo 6638179, Japan.
   [Fukushima, Kazuhito] Natl Cerebral & Cardiovasc Ctr, Dept Radiol, Osaka, Japan.
   [Umetani, Keiji] Japan Synchrotron Radiat Res Inst, Sayo, Japan.
   [Mori, Hidezo] Tokai Univ, Sch Med, Dept Physiol, Isehara, Kanagawa 25911, Japan.
   [Sugimura, Kazuro] Kobe Univ, Grad Sch Med, Dept Radiol, Kobe, Hyogo 657, Japan.
C3 Mukogawa Women's University; National Cerebral & Cardiovascular Center -
   Japan; Japan Synchrotron Radiation Research Institute; Tokai University;
   Kobe University
RP Kagota, S (corresponding author), Mukogawa Womens Univ, Sch Pharm & Pharmaceut Sci, Dept Pharmacol, 11-68 Koshien Kyuban Cho, Nishinomiya, Hyogo 6638179, Japan.
EM skagota@mukogawa-u.ac.jp
FU Open Research Center Project of Mukogawa Women's University; Ministry of
   Education, Science, Sports and Culture of Japan; Smoking Research
   Foundation, Japan; Grants-in-Aid for Scientific Research [22500423]
   Funding Source: KAKEN
FX We offer special thanks to Dr John J McGuire (Memorial University,
   Canada) for invaluable advice and criticism during the preparation of
   the manuscript. We sincerely thank Dr John S. Smeda (Memorial
   University, Canada) for the critical reading of the manuscript.
   Synchrotron radiation experiments were carried out at the BL28B2 in
   SPring-8 (Sayo, Japan) with the approval of the Japan Synchrotron
   Radiation Research Institute (Acceptance No. 2008A1512 and 2008B1050).
   We thank Daiichi-Sankyo Co., Ltd. for supplying olmesartan midoxomil and
   Dainippon Sumitomo Pharma Co., Ltd. for supplying amlodipine. We thank
   Ms Y Ishigami, Ms M Bessho, Ms K Fujie, Ms S Matsumoto, Ms M Kawamoto,
   Ms K Nishida, Ms M Hayashida, Ms M Miyaguchi and Ms N Nose for their
   technical assistance. This research was partly supported by the Open
   Research Center Project of Mukogawa Women's University for studying
   lifestyle-related diseases, a Grant-in-Aid for Scientific Research from
   the Ministry of Education, Science, Sports and Culture of Japan, and a
   grant from the Smoking Research Foundation, Japan.
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NR 45
TC 28
Z9 31
U1 0
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0305-1870
EI 1440-1681
J9 CLIN EXP PHARMACOL P
JI Clin. Exp. Pharmacol. Physiol.
PD NOV
PY 2010
VL 37
IS 11
BP 1035
EP 1043
DI 10.1111/j.1440-1681.2010.05432.x
PG 9
WC Pharmacology & Pharmacy; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Physiology
GA 672OI
UT WOS:000283595000001
PM 20659132
DA 2025-06-11
ER

PT J
AU Tang, RY
   Fan, YB
   Luo, M
   Zhang, DD
   Xie, ZL
   Huang, FL
   Wang, YC
   Liu, GF
   Wang, YP
   Lin, SQ
   Chen, R
AF Tang, Ruiyi
   Fan, Yubo
   Luo, Min
   Zhang, Duoduo
   Xie, Zhuolin
   Huang, Feiling
   Wang, Yuchen
   Liu, Gaifen
   Wang, Yaping
   Lin, Shouqing
   Chen, Rong
TI General and Central Obesity Are Associated With Increased Severity of
   the VMS and Sexual Symptoms of Menopause Among Chinese Women: A
   Longitudinal Study
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Article
DE obesity; menopause; abdominal obesity; menopausal symptoms; vasomotor
   symptoms; mood symptoms
ID QUALITY-OF-LIFE; BODY-MASS INDEX; METABOLIC SYNDROME; HOSPITAL ANXIETY;
   HOT FLASHES; VASOMOTOR SYMPTOMS; PHYSICAL-ACTIVITY; RISK-FACTORS;
   TRANSITION; DEPRESSION
AB BackgroundStrong evidence has linked overweight and obesity to increased risks of cardiovascular disease and all-cause mortality in Chinese populations. Menopause is considered associated with increased obesity and central body fat distribution. However, the correlation between obesity and menopausal symptoms has not been well studied. ObjectiveTo examine the associations between obesity or abdominal obesity and menopausal symptoms as women progressed from premenopausal to postmenopausal status. DesignThis study included 430 midlife Chinese women who had experienced natural menopause and were followed up for 10 years. Physical examinations and questionnaires should be completed annually. The questionnaires include the Menopause-Specific Quality of Life questionnaire, the Hospital Anxiety and Depression Scale, and other physical and behavioral factors. ResultsAmong women who were not obese (n=345) or not abdominal obese (n=372) at baseline, 5.8% and 31.7% became obese or abdominal obese at the recent follow-up visit, respectively. Women at the recent follow-up visit had an increased body mass index (BMI) by 0.14%, and the waist-to-hip ratio (WHR) increased by 5.2% compared with the data at baseline. In multivariate analysis, more frequent hot flashes, moderate/severe bothered vasomotor symptoms (VMS), mild bothered sexual functioning, and less anxiety symptoms were significantly associated with obesity. Increasing age, moderate/severe bothered VMS, and less anxiety symptoms were independently associated with abdominal obesity. Multivariable analysis also showed that less education level is independently associated with both obesity and abdominal obesity. ConclusionOur findings suggest that the proportion of obesity and abdominal obesity increased gradually during menopause. The increase of abdominal obesity is more rapidly than obesity in middle-aged women. Both obesity and abdominal obesity are related with severe or frequent VMS and anxiety symptoms in Chinese women. Although the proportion of obese women in China is lower than in western countries, the problem of abdominal obesity and related complications cannot be ignored.
RI Tang, RuiYi/LXA-2394-2024; Huang, Feiling/LVR-0791-2024
OI Huang, Feiling/0000-0002-4464-3599; Chen, Rong/0000-0001-8751-9590
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NR 67
TC 17
Z9 20
U1 3
U2 10
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD APR 26
PY 2022
VL 13
AR 814872
DI 10.3389/fendo.2022.814872
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 6M8OY
UT WOS:000889123800001
PM 35557846
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Araújo, MC
   Soczek, SHS
   Pontes, JP
   Marques, LAC
   Santos, GS
   Simao, G
   Bueno, LR
   Maria-Ferreira, D
   Muscará, MN
   Fernandes, ES
AF Araujo, Mizael C.
   Soczek, Suzany H. S.
   Pontes, Jaqueline P.
   Marques, Leonardo A. C.
   Santos, Gabriela S.
   Simao, Gisele
   Bueno, Laryssa R.
   Maria-Ferreira, Daniele
   Muscara, Marcelo N.
   Fernandes, Elizabeth S.
TI An Overview of the TRP-Oxidative Stress Axis in Metabolic Syndrome:
   Insights for Novel Therapeutic Approaches
SO CELLS
LA English
DT Review
DE TRP channels; metabolic syndrome; energy metabolism;
   hypoadiponectinemia; reactive oxygen species; inflammation
ID RECEPTOR POTENTIAL CHANNELS; DIET-INDUCED OBESITY; BETA-CELL FUNCTION;
   GLUCAGON-LIKE PEPTIDE-1; GLYCATION END-PRODUCTS; BROWN ADIPOSE-TISSUE;
   KAPPA-B-ACTIVATION; INSULIN-RESISTANCE; SKELETAL-MUSCLE; ION-CHANNEL
AB Metabolic syndrome (MS) is a complex pathology characterized by visceral adiposity, insulin resistance, arterial hypertension, and dyslipidaemia. It has become a global epidemic associated with increased consumption of high-calorie, low-fibre food and sedentary habits. Some of its underlying mechanisms have been identified, with hypoadiponectinemia, inflammation and oxidative stress as important factors for MS establishment and progression. Alterations in adipokine levels may favour glucotoxicity and lipotoxicity which, in turn, contribute to inflammation and cellular stress responses within the adipose, pancreatic and liver tissues, in addition to hepatic steatosis. The multiple mechanisms of MS make its clinical management difficult, involving both non-pharmacological and pharmacological interventions. Transient receptor potential (TRP) channels are non-selective calcium channels involved in a plethora of physiological events, including energy balance, inflammation and oxidative stress. Evidence from animal models of disease has contributed to identify their specific contributions to MS and may help to tailor clinical trials for the disease. In this context, the oxidative stress sensors TRPV1, TRPA1 and TRPC5, play major roles in regulating inflammatory responses, thermogenesis and energy expenditure. Here, the interplay between these TRP channels and oxidative stress in MS is discussed in the light of novel therapies to treat this syndrome.
C1 [Araujo, Mizael C.; Santos, Gabriela S.] Univ CEUMA, Programa Posgrad, BR-65075120 Sao Luis, MA, Brazil.
   [Soczek, Suzany H. S.; Simao, Gisele; Bueno, Laryssa R.; Maria-Ferreira, Daniele; Fernandes, Elizabeth S.] Inst Pesquisa Pele Pequeno Principe, BR-80250060 Curitiba, PR, Brazil.
   [Soczek, Suzany H. S.; Simao, Gisele; Bueno, Laryssa R.; Maria-Ferreira, Daniele; Fernandes, Elizabeth S.] Fac Pequeno Principe, Programa Posgrad Biotecnol Aplicada Saude Crianca, BR-80230020 Curitiba, PR, Brazil.
   [Pontes, Jaqueline P.] Univ Fed Maranhao, Programa Posgrad Ciencias Saude, BR-56508508 Sao Luis, MA, Brazil.
   [Marques, Leonardo A. C.; Muscara, Marcelo N.] Univ Sao Paulo, Inst Biomed Sci, Dept Pharmacol, BR-05508000 Sao Paulo, SP, Brazil.
C3 Universidade Ceuma; Universidade Federal do Maranhao; Universidade de
   Sao Paulo
RP Fernandes, ES (corresponding author), Inst Pesquisa Pele Pequeno Principe, BR-80250060 Curitiba, PR, Brazil.; Fernandes, ES (corresponding author), Fac Pequeno Principe, Programa Posgrad Biotecnol Aplicada Saude Crianca, BR-80230020 Curitiba, PR, Brazil.
EM mizaelcalacioo@outlook.com; suzanyhellen@gmail.com;
   jaquelinepessoasp@gmail.com; leomarques996@gmail.com;
   gabyiisantos9@gmail.com; gisele_si@hotmail.com;
   laryssaregis@hotmail.com; daniele.ferreira@pelepequenoprincipe.org.br;
   muscara@usp.br; elizabeth.fernandes@pelepequenoprincipe.org.br
RI Maria-Ferreira, Daniele/AAE-9373-2020; Fernandes, Elizabeth/J-9397-2012;
   Maria-Ferreira, Daniele/L-6905-2013; Muscara, Marcelo/F-3250-2012
OI Santos, Gabriela/0000-0003-2947-5133; Maria-Ferreira,
   Daniele/0000-0001-7992-510X; da Costa Marques, Leonardo
   Andre/0000-0001-6022-1460; Muscara, Marcelo/0000-0002-8342-5586; Pessoa
   Pontes, Jaqueline/0000-0002-4878-1761; Simao,
   Gisele/0000-0002-4180-668X; Fernandes, Elizabeth S./0000-0002-0567-2514;
   Calacio Araujo, Mizael/0000-0002-2720-8181; Soczek,
   Suzany/0000-0002-5624-3920
FU Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq;
   Brazil) [305676/2019-9, 408053/2018-6]; Instituto de Pesquisa Pele
   Pequeno Principe (Brazil); INCT-INOVAMED (Brazil); FundacAo de Amparo a
   Pesquisa e ao Desenvolvimento Cientifico e Tecnologico do MaranhAo
   (FAPEMA, Brazil); CoordenacAo de Aperfeicoamento de Pessoal de Nivel
   Superior (CAPES) [001]; Instituto de Pesquisa Pele Pequeno Principe
FX This work was supported by the Conselho Nacional de Desenvolvimento
   Cientifico e Tecnologico (CNPq; Brazil; grant numbers: 305676/2019-9 and
   408053/2018-6), the Instituto de Pesquisa Pele Pequeno Principe
   (Brazil), and INCT-INOVAMED (Brazil). M.C.A. and J.P.P. are PhD students
   receiving a grant from FundacAo de Amparo a Pesquisa e ao
   Desenvolvimento Cientifico e Tecnologico do MaranhAo (FAPEMA, Brazil),
   L.A.C.M. and L.R.B. are PhD students, and G.S. an MSc student receiving
   grants from the CoordenacAo de Aperfeicoamento de Pessoal de Nivel
   Superior (CAPES; finance code 001; Brazil). S.H.S.S. is a PhD student
   receiving a grant from the Instituto de Pesquisa Pele Pequeno Principe.
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NR 334
TC 9
Z9 10
U1 0
U2 11
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2073-4409
J9 CELLS-BASEL
JI Cells
PD APR
PY 2022
VL 11
IS 8
AR 1292
DI 10.3390/cells11081292
PG 35
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA 0S5YU
UT WOS:000786349700001
PM 35455971
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Hid, EJ
   Mosele, J
   Prince, PD
   Fraga, CG
   Galleano, M
AF Hid, Ezequiel J.
   Mosele, Juana, I
   Prince, Paula D.
   Fraga, Cesar G.
   Galleano, Monica
TI (-)-Epicatechin and cardiometabolic risk factors: a focus on potential
   mechanisms of action
SO PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
LA English
DT Review
DE (-)-Epicatechin; Dyslipidemias; Obesity; Insulin resistance;
   Hypertension; NADPH oxidase; Nitric oxide; Inflammation
ID PURE FLAVONOIDS EPICATECHIN; REDUCES BLOOD-PRESSURE; NADPH OXIDASE
   ACTIVITY; DIET-INDUCED OBESITY; NITRIC-OXIDE; ENDOTHELIAL-CELLS;
   DOUBLE-BLIND; OXIDATIVE STRESS; ADIPOSE-TISSUE; IN-VITRO
AB This review summarizes experimental evidence on the beneficial effects of (-)-epicatechin (EC) attenuating major cardiometabolic risk factors, i.e., dyslipidemias, obesity (adipose tissue dysfunction), hyperglycemia (insulin resistance), and hypertension (endothelial dysfunction). Studies in humans are revised and complemented with experiments in animal models, and cultured cells, aiming to understand the molecular mechanisms involved in EC-mediated effects. Firstly, an assessment of EC metabolism gives relevance to both conjugated-EC metabolites product of host metabolism and microbiota-derived species. Integration and analysis of results stress the maintenance of redox homeostasis and mitigation of inflammation as relevant processes associated with cardiometabolic diseases. In these processes, EC appears having significant effects regulating NADPH oxidase (NOX)-dependent oxidant production, nitric oxide (NO) production, and energy homeostasis (mitochondrial biogenesis and function). The potential participation of cell membranes and membrane-bound receptors is also discussed in terms of direct molecular action of EC and EC metabolites reaching cells and tissues.
C1 [Hid, Ezequiel J.; Mosele, Juana, I; Prince, Paula D.; Fraga, Cesar G.; Galleano, Monica] Univ Buenos Aires, Fac Farm & Bioquim, Dept Ciencias Quim, Catedra Fisicoquim, Junin 956, RA-1113 Buenos Aires, DF, Argentina.
   [Hid, Ezequiel J.; Mosele, Juana, I; Prince, Paula D.; Fraga, Cesar G.; Galleano, Monica] Univ Buenos Aires, Inst Bioquim & Med Mol IBIMOL, CONICET, Buenos Aires, DF, Argentina.
   [Fraga, Cesar G.] Univ Calif Davis, Dept Nutr, Davis, CA 95616 USA.
C3 University of Buenos Aires; Consejo Nacional de Investigaciones
   Cientificas y Tecnicas (CONICET); University of Buenos Aires; University
   of California System; University of California Davis
RP Galleano, M (corresponding author), Univ Buenos Aires, Fac Farm & Bioquim, Dept Ciencias Quim, Catedra Fisicoquim, Junin 956, RA-1113 Buenos Aires, DF, Argentina.; Galleano, M (corresponding author), Univ Buenos Aires, Inst Bioquim & Med Mol IBIMOL, CONICET, Buenos Aires, DF, Argentina.
EM ejhid@docente.ffyb.uba.ar; pdprince@ffyb.uba.ar; cfraga@ffyb.uba.ar;
   mgallean@ffyb.uba.ar
RI Fraga, Cesar/Q-8161-2019; Prince, Paula/O-5318-2019; Mosele,
   Juana/AAD-1793-2022
OI Prince, Paula Denise/0000-0002-7075-4014; Mosele, Juana
   Ines/0000-0002-0600-2360; Fraga, Cesar G./0000-0003-4168-9927; Hid,
   Ezequiel/0000-0002-3741-2194
FU University of Buenos Aires, Argentina [20020170100586BA,
   20020190100157BA]; National Scientific and Technical Research
   Council-Argentina [PIP11220170100585CO]; National Agency for Scientific
   and Technological Promotion, Argentina [PICT2018-03052]
FX This work was supported by grants from University of Buenos Aires,
   Argentina, 20020170100586BA (MG) and 20020190100157BA (CGF), National
   Scientific and Technical Research Council-Argentina PIP11220170100585CO
   (MG), and National Agency for Scientific and Technological Promotion,
   Argentina PICT2018-03052 (MG).
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NR 113
TC 12
Z9 12
U1 0
U2 13
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0031-6768
EI 1432-2013
J9 PFLUG ARCH EUR J PHY
JI Pflugers Arch.
PD JAN
PY 2022
VL 474
IS 1
SI SI
BP 99
EP 115
DI 10.1007/s00424-021-02640-0
EA NOV 2021
PG 17
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA YD3CM
UT WOS:000721681400001
PM 34812946
DA 2025-06-11
ER

PT J
AU Prabahar, K
   Ravikumar, A
   Jeyabalan, AP
   Ravi, B
   Ravikumar, C
   Pannirukaiselvan, N
   Alqifari, SF
   Sivaraman, V
   Shanmugasundaram, N
   Sankar, K
AF Prabahar, Kousalya
   Ravikumar, Abinaya
   Jeyabalan, Anu Priya
   Ravi, Bharath
   Ravikumar, Chandini
   Pannirukaiselvan, Nithishadevi
   Alqifari, Saleh F.
   Sivaraman, Varadharajan
   Shanmugasundaram, Natarajan
   Sankar, Karthik
TI Agomelatine with cognitive behavioral therapy reduces insomnia severity
   index and subjective units of distress scores than initial-dose
   clonazepam in moderate to severe insomnia patients: A quasi-experimental
   study
SO PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
LA English
DT Article
DE Clonazepam; Agomelatine; Cognitive behavioral therapy; Insomnia severity
   index
ID MAJOR DEPRESSIVE DISORDER; METABOLIC SYNDROME; SLEEP DURATION;
   BENZODIAZEPINES; METAANALYSIS; EFFICACY
AB Background: Insomnia can be caused by various factors including lack of sleep, stress, sadness, hormonal changes, excessive caffeine, anxiety, mental health disorders, and medications. Treatments include finding the cause, improving sleep patterns, using behavioral therapy, and taking sleeping pills in most cases. However, the drugs often cause worse side effects than insomnia. This study compared the efficacy of initial agomelatine and clonazepam doses with cognitive behavioral therapy for insomnia (CBT-i) in moderate to severe insomnia patients. Methods: This quasi-experiment study involved 230 moderate to severe insomnia patients with group A as clonazepam 0.25 mg and B as agomelatine 25 mg. CBT-i was received by both of the groups and the Insomnia Severity Index (ISI), Subjective Units of Distress Scale (SUDS) score, medication adherence, and Adverse Drug Reactions (ADRs) were followed for up to 24 weeks. Results: In the comparative analysis between and within groups, group B exhibited a significant reduction in ISI (p = 0.001) and SUDS (p = 0.001) scores at week 24 compared to group A. Overall, both groups demonstrated improved adherence. However, 12 patients in group A and 10 in group B experienced ADR, which included drowsiness, hypersalivation, diarrhea, maculopapular rash, and myotoxicity. The clonazepam-treated group showed reduced efficacy from week 12 onwards in the ISI and from week 16 in the SUDS median score, which was not observed in the agomelatine group. Conclusion: The initial dose of agomelatine with CBT-i has a better impact on improving moderate to severe insomnia than the initial dose of clonazepam with CBT-i.
C1 [Prabahar, Kousalya; Alqifari, Saleh F.] Univ Tabuk, Fac Pharm, Dept Pharm Practice, Tabuk, Saudi Arabia.
   [Ravikumar, Abinaya; Jeyabalan, Anu Priya; Ravi, Bharath; Ravikumar, Chandini; Pannirukaiselvan, Nithishadevi] Sri Ramachandra Inst Higher Educ & Res DU, Sri Ramachandra Fac Pharm, Porur, Tamil Nadu, India.
   [Sivaraman, Varadharajan] Sri Ramachandra Inst Higher Educ & Res DU, Dept Clin Psychol, Porur, Tamil Nadu, India.
   [Shanmugasundaram, Natarajan] Sri Ramachandra Inst Higher Educ & Res, Sri Ramachandra Med Coll & Res Inst, Dept Psychiat, Chennai 600116, Tamil Nadu, India.
C3 University of Tabuk; Sri Ramachandra Institute of Higher Education &
   Research; Sri Ramachandra Institute of Higher Education & Research; Sri
   Ramachandra Institute of Higher Education & Research
RP Sankar, K (corresponding author), Sri Ramachandra Inst Higher Educ & Res, Sri Ramachandra Fac Pharm, Dept Pharm Practice, Chennai 600116, Tamil Nadu, India.
EM karthiksjn19@gmail.com
RI sankar, Dr. karthik/JXM-2262-2024; Alqifari, Saleh/HLX-5079-2023;
   Prabahar, Kousalya/AAE-6842-2021
OI Prabahar, Kousalya/0000-0001-8224-4276
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NR 40
TC 0
Z9 0
U1 0
U2 0
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0091-3057
EI 1873-5177
J9 PHARMACOL BIOCHEM BE
JI Pharmacol. Biochem. Behav.
PD JUN
PY 2025
VL 251
AR 174003
DI 10.1016/j.pbb.2025.174003
EA APR 2025
PG 6
WC Behavioral Sciences; Neurosciences; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Behavioral Sciences; Neurosciences & Neurology; Pharmacology & Pharmacy
GA 1FM6K
UT WOS:001463793400001
PM 40157395
DA 2025-06-11
ER

PT J
AU Anderson, R
   Agarwal, A
   Ghosh, A
   Guan, BJ
   Casteel, J
   Dvorina, N
   Baldwin, WM
   Mazumder, B
   Nazarko, TY
   Merrick, WC
   Buchner, DA
   Hatzoglou, M
   Kondratov, RV
   Komar, AA
AF Anderson, Richard
   Agarwal, Anchal
   Ghosh, Arnab
   Guan, Bo-Jhih
   Casteel, Jackson
   Dvorina, Nina
   Baldwin, William M.
   Mazumder, Barsanjit
   Nazarko, Taras Y.
   Merrick, William C.
   Buchner, David A.
   Hatzoglou, Maria
   Kondratov, Roman, V
   Komar, Anton A.
TI eIF2A-knockout mice reveal decreased life span and metabolic syndrome
SO FASEB JOURNAL
LA English
DT Article
DE ER stress; eukaryotic initiation factor 2A (eIF2A); life span; lipid
   homeostasis; metabolic syndrome
ID EUKARYOTIC TRANSLATION INITIATION; DIET-INDUCED OBESITY;
   PROTEIN-SYNTHESIS; B-CELLS; MECHANISM; HOMEOSTASIS; PATHOPHYSIOLOGY;
   DIFFERENTIATION; EXPRESSION; PRINCIPLES
AB Eukaryotic initiation factor 2A (eIF2A) is a 65 kDa protein that functions in minor initiation pathways, which affect the translation of only a subset of messenger ribonucleic acid (mRNAs), such as internal ribosome entry site (IRES)-containing mRNAs and/or mRNAs harboring upstream near cognate/non-AUG start codons. These non-canonical initiation events are important for regulation of protein synthesis during cellular development and/or the integrated stress response. Selective eIF2A knockdown in cellular systems significantly inhibits translation of such mRNAs, which rely on alternative initiation mechanisms for their translation. However, there exists a gap in our understanding of how eIF2A functions in mammalian systems in vivo (on the organismal level) and ex vivo (in cells). Here, using an eIF2A-knockout (KO) mouse model, we present evidence implicating eIF2A in the biology of aging, metabolic syndrome and central tolerance. We discovered that eIF2A-KO mice have reduced life span and that eIF2A plays an important role in maintenance of lipid homeostasis, the control of glucose tolerance, insulin resistance and also reduces the abundance of B lymphocytes and dendritic cells in the thymic medulla of mice. We also show the eIF2A KO affects male and female mice differently, suggesting that eIF2A may affect sex-specific pathways. Interestingly, our experiments involving pharmacological induction of endoplasmic reticulum (ER) stress with tunicamycin did not reveal any substantial difference between the response to ER stress in eIF2A-KO and wild-type mice. The identification of eIF2A function in the development of metabolic syndrome bears promise for the further identification of specific eIF2A targets responsible for these changes.
C1 [Anderson, Richard; Agarwal, Anchal; Ghosh, Arnab; Casteel, Jackson; Mazumder, Barsanjit; Kondratov, Roman, V; Komar, Anton A.] Cleveland State Univ, Ctr Gene Regulat Hlth & Dis, Dept Biol Geol & Environm Sci, Cleveland, OH 44115 USA.
   [Guan, Bo-Jhih; Buchner, David A.; Hatzoglou, Maria] Case Western Reserve Univ, Sch Med, Dept Genet & Genome Sci, Cleveland, OH USA.
   [Dvorina, Nina; Baldwin, William M.] Cleveland Clin, Dept Inflammat & Immun, Lerner Coll Med, Cleveland, OH 44106 USA.
   [Nazarko, Taras Y.] Georgia State Univ, Dept Biol, Atlanta, GA USA.
   [Merrick, William C.; Buchner, David A.; Komar, Anton A.] Case Western Reserve Univ, Sch Med, Dept Biochem, Cleveland, OH 44106 USA.
C3 University System of Ohio; Cleveland State University; University System
   of Ohio; Case Western Reserve University; University System of Ohio;
   Case Western Reserve University; Cleveland Clinic Foundation; University
   System of Georgia; Georgia State University; University System of Ohio;
   Case Western Reserve University
RP Komar, AA (corresponding author), Cleveland State Univ, Ctr Gene Regulat Hlth & Dis, Cleveland, OH 44115 USA.; Komar, AA (corresponding author), Cleveland State Univ, Dept Biol Geol & Environm Sci, Cleveland, OH 44115 USA.
EM a.komar@csuohio.edu
RI ; GHOSH, ARNAB/J-2299-2019
OI Komar, Anton/0000-0003-4188-0633; GHOSH, ARNAB/0000-0003-1952-1044;
   Agarwal, Anchal/0009-0004-2183-9478
FU NIH [GM128981, HL151392, DK119305, GM119571, DK053307, DK060596,
   HL079164, AG039547]; Center for Gene Regulation in Health and Disease
   (GRHD); CSU; National Institute of General Medical Sciences
   [R01GM128981] Funding Source: NIH RePORTER
FX This work was supported by NIH grants GM128981 (AAK, WCM, DAB) and in
   part by HL151392 (AAK), DK119305 (DAB), GM119571 (TYN), DK053307 and
   DK060596 (MH), HL079164 (BM) and AG039547 (RVK) and internal funds from
   the Center for Gene Regulation in Health and Disease (GRHD) and CSU to
   AAK
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NR 78
TC 13
Z9 16
U1 0
U2 11
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0892-6638
EI 1530-6860
J9 FASEB J
JI Faseb J.
PD NOV
PY 2021
VL 35
IS 11
AR e21990
DI 10.1096/fj.202101105R
PG 23
WC Biochemistry & Molecular Biology; Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA WN8IK
UT WOS:000712009200042
PM 34665898
OA Green Published
DA 2025-06-11
ER

PT J
AU Maruyama, K
   Kagota, S
   McGuire, JJ
   Wakuda, H
   Yoshikawa, N
   Nakamura, K
   Shinozuka, K
AF Maruyama, Kana
   Kagota, Satomi
   McGuire, John J.
   Wakuda, Hirokazu
   Yoshikawa, Noriko
   Nakamura, Kazuki
   Shinozuka, Kazumasa
TI Age-related changes to vascular protease-activated receptor 2 in
   metabolic syndrome: a relationship between oxidative stress, receptor
   expression, and endothelium-dependent vasodilation
SO CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
LA English
DT Article
DE protease-activated receptor 2; receptor expression;
   endothelium-dependent vasodilation; metabolic syndrome; oxidative stress
ID SPONTANEOUSLY HYPERTENSIVE-RATS; SHRSP.Z-LEPRFA/IZMDMCR RATS;
   SHR/NDMCR-CP RATS; CEREBRAL-ARTERY; MESENTERIC-ARTERY; ANIMAL-MODEL;
   INFLAMMATION; DYSFUNCTION; MECHANISMS; OBESITY
AB Protease-activated receptor 2 (PAR2) is expressed in vascular endothelium. Nitric oxide (NO) - cyclic GMP-mediated vasodilation in response to 2-furoyl-LIGRLO-amide (2fLIGRLO), a PAR2-activating peptide, is impaired in aortas from aged SHRSP. Z-Lepr(fa)/IzmDmcr (SHRSP. ZF) rats with metabolic syndrome. Here we investigated mechanisms linking PAR2's vascular effects to phenotypic characteristics of male SHRSP. ZF rats at 10, 20, and 30 weeks of age. We found vasodilation responses to either 2fLIGRLO or enzyme-mediated PAR2 activation by trypsin were sustained until 20 weeks and lessened at 30 weeks. PAR2 protein and mRNA levels were lower in aortas at 30 weeks than at 10 and 20 weeks. PAR2-mediated responses positively correlated with PAR2 protein and mRNA levels. Decreased cGMP accumulation in the presence of 2fLIGRLO paralleled the decreased relaxations elicited by nitroprusside and the cGMP analog 8-pCPT-cGMP, and the less soluble guanylyl cyclase protein at 30 weeks. 2fLIGRLO-induced relaxation was negatively correlated with serum thiobarbituric acid reactive substances, an index of oxidative stress, which increased with age. Forward stepwise data regression supported a model of age-related decreases in PAR2 function resulting from decreased PAR2 mRNA and increased oxidative stress. We conclude that decreased responsiveness of aortic smooth muscle to NO and downregulation of receptor expression impair PAR2 functions at later stages of metabolic syndrome in SHRSP. ZF rats.
C1 [Maruyama, Kana; Kagota, Satomi; Wakuda, Hirokazu; Yoshikawa, Noriko; Nakamura, Kazuki; Shinozuka, Kazumasa] Mukogawa Womens Univ, Sch Pharm & Pharmaceut Sci, Dept Pharmacol, 11-68 Koshien Kyuban Cho, Nishinomiya, Hyogo 6638179, Japan.
   [McGuire, John J.] Mem Univ Newfoundland, Fac Med, Div Biomed Sci, Cardiovasc Res Grp, 300 Prince Philip Dr, St John, NF A1B 3V6, Canada.
C3 Mukogawa Women's University; Memorial University Newfoundland
RP Kagota, S (corresponding author), Mukogawa Womens Univ, Sch Pharm & Pharmaceut Sci, Dept Pharmacol, 11-68 Koshien Kyuban Cho, Nishinomiya, Hyogo 6638179, Japan.
EM skagota@mukogawa-u.ac.jp
RI Wakuda, Hirokazu/KZU-6319-2024
OI Wakuda, Hirokazu/0000-0002-5717-8251; McGuire, John/0000-0003-0302-3884
FU MEXT KAKENHI [23590315]; Grants-in-Aid for Scientific Research
   [16K18969, 23590315] Funding Source: KAKEN
FX The authors express sincere gratitude to Saki Iwata, Akiko Ogura, and
   Natsumi Maruyama for technical assistance. This study was partly
   supported by MEXT KAKENHI (grant No. 23590315).
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NR 43
TC 9
Z9 10
U1 0
U2 5
PU CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS
PI OTTAWA
PA 65 AURIGA DR, SUITE 203, OTTAWA, ON K2E 7W6, CANADA
SN 0008-4212
EI 1205-7541
J9 CAN J PHYSIOL PHARM
JI Can. J. Physiol. Pharmacol.
PD APR
PY 2017
VL 95
IS 4
BP 356
EP 364
DI 10.1139/cjpp-2016-0298
PG 9
WC Pharmacology & Pharmacy; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Physiology
GA ER5JK
UT WOS:000398837600006
PM 28103056
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Reynolds, RM
AF Reynolds, R. M.
TI Nick Hales Award Lecture 2011: glucocorticoids and early life
   programming of cardiometabolic disease
SO JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE
LA English
DT Review
DE cardiometabolic disease; glucocorticoids; programming
ID LOW-BIRTH-WEIGHT; PLASMA-CORTISOL CONCENTRATIONS; MESSENGER-RNA
   EXPRESSION; CORONARY-ARTERY-DISEASE; METABOLIC SYNDROME; HEART-DISEASE;
   STRESS; PEOPLE; RISK; DEXAMETHASONE
AB Epidemiological studies have demonstrated an association between low birthweight and a range of diseases in adult life including cardiometabolic and psychiatric diseases. One of the key mechanisms proposed to underlie early life 'programming' of disease is overexposure of the developing foetus to glucocorticoids. This review will explore the data from human studies that glucocorticoids are not only mediators of programming, but also targets of programming. Cohort studies of men and women of known birthweight have demonstrated that low birthweight is associated with high fasting cortisol levels. In healthy individuals and in people with type 2 diabetes who are at high cardiovascular risk, there is a similar association between high fasting cortisol and the metabolic syndrome. The high cortisol levels appear to be due to activation of the hypothalamic-pituitary-adrenal (HPA) axis though detailed studies to further explore central negative feedback sensitivity are required. The evidence in humans that glucocorticoids mediate programming is more scanty, though changes in maternal body composition, stress and anxiety levels and activity of the placental barrier enzyme 11 beta-hydroxysteroid dehydrogenase type 2 (11 beta-HSD2) may all influence maternal HPA axis activity. Emerging studies are supportive that high maternal cortisol levels in humans and/or deficiencies placental 11 beta-HSD2 humans are associated with lower birthweight and adverse metabolic and neurocognitive outcomes in the offspring.
C1 Univ Edinburgh, Univ BHF Ctr Cardiovasc Sci, Queens Med Res Inst, Endocrinol Unit, Edinburgh EH16 4TJ, Midlothian, Scotland.
C3 University of Edinburgh
RP Reynolds, RM (corresponding author), Univ Edinburgh, Univ BHF Ctr Cardiovasc Sci, Queens Med Res Inst, Endocrinol Unit, 47 Little France Crescent, Edinburgh EH16 4TJ, Midlothian, Scotland.
EM R.Reynolds@ed.ac.uk
RI Reynolds, Rebecca M/C-3044-2008
OI Reynolds, Rebecca M/0000-0001-6226-8270
FU Wellcome Trust; British Heart Foundation; Sir Jules Thorne Charitable
   Trust; Medical Research Council; Chief Scientist Office, Scotland;
   Tommys
FX The work for this award was carried out when the author was working in
   both Southampton at the MRC Unit, and in Edinburgh at the QMRI. The
   author has been supported by grants from the Wellcome Trust, British
   Heart Foundation, Sir Jules Thorne Charitable Trust, Medical Research
   Council, Chief Scientist Office, Scotland and Tommys. She would like to
   acknowledge her mentors in Southampton (Professors Barker, Phillips and
   Godfrey) and in Edinburgh (Professors Walker and Seckl) and her
   colleagues who have assisted with the work at both sites. The author
   also thanks the men and women who have participated in the studies
   without whom, none of this work would have been possible.
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NR 48
TC 10
Z9 10
U1 0
U2 7
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 2040-1744
EI 2040-1752
J9 J DEV ORIG HLTH DIS
JI J. Dev. Orig. Health Dis.
PD OCT
PY 2012
VL 3
IS 5
BP 309
EP 314
DI 10.1017/S2040174412000311
PG 6
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA 999JQ
UT WOS:000308307800002
PM 25102258
DA 2025-06-11
ER

PT J
AU Poudyal, H
   Panchal, S
   Brown, L
AF Poudyal, Hemant
   Panchal, Sunil
   Brown, Lindsay
TI Comparison of purple carrot juice and β-carotene in a high-carbohydrate,
   high-fat diet-fed rat model of the metabolic syndrome
SO BRITISH JOURNAL OF NUTRITION
LA English
DT Article
DE Purple carrots; Anthocyanins; beta-Carotene; Metabolic syndrome;
   High-carbohydrate; high-fat diet-fed rats
ID VEGETABLE INTAKE; RETINOIC ACID; ANTIOXIDANT PHYTOCHEMICALS;
   CARDIOVASCULAR-DISEASE; INSULIN-RESISTANCE; OXIDATIVE STRESS; INDUCE
   APOPTOSIS; VITAMIN-A; RISK; FRUIT
AB Anthocyanins, phenolic acids and carotenoids are the predominant phytochemicals present in purple carrots. These phytochemicals could be useful in treatment of the metabolic syndrome since anthocyanins improve dyslipidaemia, glucose tolerance, hypertension and insulin resistance; the phenolic acids may also protect against CVD and beta-carotene may protect against oxidative processes. In the present study, we have compared the ability of purple carrot juice and beta-carotene to reverse the structural and functional changes in rats fed a high-carbohydrate, high-fat diet as a model of the metabolic syndrome induced by diet. Cardiac structure and function were defined by histology, echocardiography and in isolated hearts and blood vessels; liver structure and function, oxidative stress and inflammation were defined by histology and plasma markers. High-carbohydrate, high-fat diet-fed rats developed hypertension, cardiac fibrosis, increased cardiac stiffness, endothelial dysfunction, impaired glucose tolerance, increased abdominal fat deposition, altered plasma lipid profile, liver fibrosis and increased plasma liver enzymes together with increased plasma markers of oxidative stress and inflammation as well as increased inflammatory cell infiltration. Purple carrot juice attenuated or reversed all changes while beta-carotene did not reduce oxidative stress, cardiac stiffness or hepatic fat deposition. As the juice itself contained low concentrations of carotenoids, it is likely that the anthocyanins are responsible for the antioxidant and anti-inflammatory properties of purple carrot juice to improve glucose tolerance as well as cardiovascular and hepatic structure and function.
C1 [Poudyal, Hemant; Panchal, Sunil; Brown, Lindsay] Univ Queensland, Sch Biomed Sci, Brisbane, Qld 4072, Australia.
   [Panchal, Sunil; Brown, Lindsay] Univ So Queensland, Dept Biol & Phys Sci, Toowoomba, Qld 4350, Australia.
C3 University of Queensland; University of Southern Queensland
RP Brown, L (corresponding author), Univ Queensland, Sch Biomed Sci, Brisbane, Qld 4072, Australia.
EM Lindsay.Brown@usq.edu.au
RI Poudyal, Hemant/HOH-9324-2023
OI Panchal, Sunil K/0000-0001-5464-3376
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NR 54
TC 98
Z9 103
U1 1
U2 17
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1145
EI 1475-2662
J9 BRIT J NUTR
JI Br. J. Nutr.
PD NOV
PY 2010
VL 104
IS 9
BP 1322
EP 1332
DI 10.1017/S0007114510002308
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 677TS
UT WOS:000284015300008
PM 20619064
OA Bronze
DA 2025-06-11
ER

PT J
AU Pasalic, D
   Marinkovic, N
   Feher-Turkovic, L
AF Pasalic, Daria
   Marinkovic, Natalija
   Feher-Turkovic, Lana
TI Uric acid as one of the important factors in multifactorial disorders -
   facts and controversies
SO BIOCHEMIA MEDICA
LA English
DT Review
DE atherosclerosis; hypertension; hyperuricemia; metabolic syndrome; uric
   acid
ID ACUTE HEART-FAILURE; METABOLIC SYNDROME; XANTHINE-OXIDASE; OXIDATIVE
   STRESS; BLOOD-PRESSURE; CARDIOVASCULAR MORTALITY; ENDOTHELIAL
   DYSFUNCTION; MECHANISTIC INSIGHTS; KIDNEY-DISEASE; LONG-TERM
AB With considering serum concentration of the uric acid in humans we are observing hyperuricemia and possible gout development. Many epidemiological studies have shown the relationship between the uric acid and different disorders such are obesity, metabolic syndrome, hypertension and coronary artery disease. Clinicians and investigators recognized serum uric acid concentration as very important diagnostic and prognostic factor of many multifactorial disorders. This review presented few clinical conditions which are not directly related to uric acid, but the concentrations of uric acid might have a great impact in observing, monitoring, prognosis and therapy of such disorders. Uric acid is recognized as a marker of oxidative stress. Production of the uric acid includes enzyme xanthine oxidase which is involved in producing of radical-oxigen species (ROS). As by-products ROS have a significant role in the increased vascular oxidative stress and might be involved in atherogenesis. Uric acid may inhibit endothelial function by inhibition of nitric oxide-function under conditions of oxidative stress. Down regulation of nitric oxide and induction of endothelial dysfunction might also be involved in pathogenesis of hypertension. The most important and well evidenced is possible predictive role of uric acid in predicting short-term outcome (mortality) in acute myocardial infarction (AMI) patients and stroke. Nephrolithiasis of uric acid origin is significantly more common among patients with the metabolic syndrome and obesity. On contrary to this, uric acid also acts is an "antioxidant", a free radical scavenger and a chelator of transitional metal ions which are converted to poorly reactive forms.
C1 [Pasalic, Daria] Univ Zagreb, Sch Med, Dept Chem Biochem & Clin Chem, Zagreb 41001, Croatia.
   [Marinkovic, Natalija] Quintiles Zagreb Ltd, Zagreb, Croatia.
   [Feher-Turkovic, Lana] Univ Appl Hlth Studies, Dept Chem Biochem & Clin Chem, Zagreb, Croatia.
C3 University of Zagreb; IQVIA; University of Applied Health Sciences
RP Pasalic, D (corresponding author), Univ Zagreb, Sch Med, Dept Chem Biochem & Clin Chem, Zagreb 41001, Croatia.
EM daria.pasalic@mef.hr
RI Pasalic, Daria/AAC-8025-2020
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NR 91
TC 116
Z9 123
U1 0
U2 27
PU CROATIAN SOC MEDICAL BIOCHEMISTRY & LABORATORY MEDICINE
PI ZAGREB
PA BOSKOVICEVA 18, ZAGREB, 10000, CROATIA
SN 1330-0962
EI 1846-7482
J9 BIOCHEM MEDICA
JI Biochem. Medica.
PY 2012
VL 22
IS 1
BP 63
EP 75
PG 13
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA 896UP
UT WOS:000300597200007
PM 22384520
DA 2025-06-11
ER

PT J
AU Chen, WL
   Wang, CC
   Chiang, ST
   Wang, YC
   Sun, YS
   Wu, WT
   Liou, SH
AF Chen, Wei-Liang
   Wang, Chung-Ching
   Chiang, Sheng-Ta
   Wang, Ying-Chuan
   Sun, Yu-Shan
   Wu, Wei-Te
   Liou, Saou-Hsing
TI The impact of occupational psychological hazards and metabolic syndrome
   on the 8-year risk of cardiovascular diseases-A longitudinal study
SO PLOS ONE
LA English
DT Article
ID CORONARY-HEART-DISEASE; LONG WORKING HOURS; JOB STRAIN;
   PHYSICAL-ACTIVITY; OBESITY; METAANALYSIS; HEALTH; RECOGNITION;
   ASSOCIATION; OVERWEIGHT
AB There was little information concerning the combined effect of occupational psychosocial hazards such as long working hours, high job stress, and high fatigue on the risk of cardiovascular and cerebrovascular diseases (CVD). The aim of this study was to investigate the interaction among occupational psychosocial hazards and the impact of metabolic syndrome (MetS) on the risk of CVD among bus drivers. The Taiwan Bus Driver Cohort Study involving 1014 professional drivers was established in 2005 and comprehensively studied. The interactions among occupational psychosocial hazards and the impact of MetS on the risk of CVD were measured. A working pattern questionnaire, job stress questionnaires, the Swedish occupational fatigue inventory, the stress satisfaction offset score, biochemical measurements, and physical examinations were used to assess psychosocial hazards and the presence of metabolic syndrome. There were 707 eligible bus drivers with a mean age of 43.5years old. During the 8-years of follow-up, 77 drivers were diagnosed with CVD. Long working hours, high job stress, and high fatigue were associated with an increased risk of cardiovascular disease incidence in the multivariate analysis. There were synergistic effects among long working hours, high job stress, and high fatigue only in drivers with MetS. A combination of long working hours, high job stress, and high fatigue increased the risk of developing CVD in bus drivers with MetS.
C1 [Chen, Wei-Liang; Wang, Chung-Ching; Chiang, Sheng-Ta; Wang, Ying-Chuan; Sun, Yu-Shan; Liou, Saou-Hsing] Triserv Gen Hosp, Natl Def Med Ctr, Dept Family & Community Med, Div Fanily Med,Div Occupat Med, Taipei, Taiwan.
   [Wu, Wei-Te; Liou, Saou-Hsing] Natl Inst Environm Hlth Sci, Natl Hlth Res Inst, Miaoli, Taiwan.
   [Liou, Saou-Hsing] Natl Def Med Ctr, Dept Publ Hlth, Taipei, Taiwan.
C3 National Defense Medical Center; Tri-Service General Hospital; National
   Health Research Institutes - Taiwan; National Defense Medical Center
RP Liou, SH (corresponding author), Triserv Gen Hosp, Natl Def Med Ctr, Dept Family & Community Med, Div Fanily Med,Div Occupat Med, Taipei, Taiwan.; Wu, WT; Liou, SH (corresponding author), Natl Inst Environm Hlth Sci, Natl Hlth Res Inst, Miaoli, Taiwan.; Liou, SH (corresponding author), Natl Def Med Ctr, Dept Publ Hlth, Taipei, Taiwan.
EM ader.una@gmail.com; shliou@nhri.org.tw
RI Wu, Wei-Te/S-8189-2019
OI Liou, Saou-Hsing/0000-0002-6602-4414
FU National Health Research Institutes of Taiwan [98-EO-PP01, 99-EO-PP01,
   00-EO-PP01, EO-101-PP-01, EO-102-PP-01, EO-103-PP-01]
FX Funded by National Health Research Institutes of Taiwan (98-EO-PP01,
   99-EO-PP01, 00-EO-PP01, EO-101-PP-01, EO-102-PP-01 and EO-103-PP-01) to
   Dr. Saou-Hsing Liou National Institute of Occupational Safety and
   Health, Japan (IOSH96-M102 and IOSH97-M102) to Dr. Saou-Hsing Liou.
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NR 34
TC 15
Z9 15
U1 1
U2 11
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD AUG 27
PY 2018
VL 13
IS 8
AR e0202977
DI 10.1371/journal.pone.0202977
PG 12
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Science & Technology - Other Topics
GA GR6UK
UT WOS:000442804200041
PM 30148874
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Révész, D
   Milaneschi, Y
   Verhoeven, JE
   Penninx, BWJH
AF Revesz, Dora
   Milaneschi, Yuri
   Verhoeven, Josine E.
   Penninx, Brenda W. J. H.
TI Telomere Length as a Marker of Cellular Aging Is Associated With
   Prevalence and Progression of Metabolic Syndrome
SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Article
ID INSULIN-RESISTANCE; OXIDATIVE STRESS; CARDIOVASCULAR-DISEASE;
   WEIGHT-GAIN; OBESITY; MEN; MORTALITY; GENDER; BLOOD
AB Context: Metabolic syndrome (MetS) clusters risk factors for age-related conditions including cardiovascular disease and diabetes. Shorter telomere length (TL), a cellular marker for biological age, may predict an individual's deteriorating metabolic condition.
   Objective: We examined whether shorter baseline TL is associated with a worse metabolic profile and with less favorable trajectories of MetS components over a 6-year follow-up.
   Design and Setting: Participants were part of The Netherlands Study of Depression and Anxiety, an ongoing prospective cohort study with 6-year follow-up.
   Participants: This study included 2848 participants age 18-65 years.
   Main Outcome Measures: Baseline TL from leukocytes was determined using qPCR and MetS components (waist circumference, triglycerides, high-density lipoprotein [HDL] cholesterol, systolic blood pressure, and fasting glucose) were determined at baseline, and after 2 and 6 years. Cross-sectional and longitudinal analyses were adjusted for relevant sociodemographic, lifestyle, and health factors.
   Results: Shorter baseline TL was cross-sectionally associated with HDL (beta = -0.016, SE = 0.008, P = .05), waist circumference (beta = 0.647, SE = 0.238, P = .007), triglycerides (beta = 0.038, SE = 0.009, P = .001), and fasting glucose (beta = 0.011, SE = 0.003, P = .001), as well as with the total number of MetS components (beta = 0.075, SE = 0.023, P = .001) and the presence of MetS (OR = 1.19; 95% CI, 1.07-1.33; P = .002). Although baseline differences progressively reduced over time, shorter baseline TL was still significantly associated with unfavorable scores of most MetS components at the 2- or 6-year follow-up.
   Conclusions: Cellular aging, as assessed by TL, is associated with a higher metabolic risk profile, which remains unfavorable even after a period of 6 years. These findings suggest that cellular aging might play a role in the onset of various aging-related somatic diseases via its effect on metabolic alterations.
C1 [Revesz, Dora; Milaneschi, Yuri; Verhoeven, Josine E.; Penninx, Brenda W. J. H.] Vrije Univ Amsterdam Med Ctr, EMGO Inst, Hlth & Care Inst, Dept Psychiat, NL-1081 HL Amsterdam, Netherlands.
C3 Vrije Universiteit Amsterdam; VU UNIVERSITY MEDICAL CENTER
RP Révész, D (corresponding author), AJ Ernststr 1187,Room M1-06, NL-1081 HL Amsterdam, Netherlands.
EM D.Revesz@ggzingeest.nl
RI Penninx, Brenda/S-7627-2017
OI Milaneschi, Yuri/0000-0002-3697-6617
FU Geestkracht program of The Netherlands Organisation for Health Research
   and Development (ZonMW) [10-000-1002]; VU University Medical Center; GGZ
   inGeest; Arkin; Leiden University Medical Center; GGZ Rivierduinen;
   University Medical Center Groningen; Lentis; GGZ Friesland; GGZ Drenthe;
   IQ Healthcare; Netherlands Institute for Health Services Research;
   Netherlands Institute of Mental Health and Addiction [Trimbos]; NWO-VICI
   [91811602]
FX The infrastructure for the NESDA study (www.nesda.nl) is funded through
   the Geestkracht program of The Netherlands Organisation for Health
   Research and Development (ZonMW, Grant No. 10-000-1002) and is supported
   by participating universities and mental health care organizations (VU
   University Medical Center, GGZ inGeest, Arkin, Leiden University Medical
   Center, GGZ Rivierduinen, University Medical Center Groningen, Lentis,
   GGZ Friesland, GGZ Drenthe, IQ Healthcare, Netherlands Institute for
   Health Services Research, and Netherlands Institute of Mental Health and
   Addiction [Trimbos]). B.P., D.R., J.V. and telomere length assaying were
   supported through NWO-VICI Grant No. 91811602.
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U1 0
U2 18
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0021-972X
EI 1945-7197
J9 J CLIN ENDOCR METAB
JI J. Clin. Endocrinol. Metab.
PD DEC
PY 2014
VL 99
IS 12
BP 4607
EP 4615
DI 10.1210/jc.2014-1851
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA AX1ZP
UT WOS:000346743300032
PM 25188715
OA Bronze
DA 2025-06-11
ER

PT J
AU Sohouli, MH
   Lari, A
   Fatahi, S
   Shidfar, F
   Gaman, MA
   Guimaraes, NS
   Sindi, GA
   Mandili, RA
   Alzahrani, GR
   Abdulwahab, RA
   Almuflihi, AM
   Alsobyani, FM
   Mahmud, AMA
   Nazzal, O
   Alshaibani, L
   Elmokid, S
   Abu-Zaid, A
AF Sohouli, Mohammad Hassan
   Lari, Abolfazl
   Fatahi, Somaye
   Shidfar, Farzad
   Gaman, Mihnea-Alexandru
   Guimaraes, Nathalia Sernizon
   Sindi, Ghufran Abdullatif
   Mandili, Rasha Abdulaziz
   Alzahrani, Ghaida Rashed
   Abdulwahab, Rahaf Abdulrashid
   Almuflihi, Alhanouf Mohammed
   Alsobyani, Faris Mohammed
   Mahmud, Amna Malik Albu
   Nazzal, Osama
   Alshaibani, Lama
   Elmokid, Shouq
   Abu-Zaid, Ahmed
TI Impact of soy milk consumption on cardiometabolic risk factors: A
   systematic review and meta-analysis of randomized controlled trials
SO JOURNAL OF FUNCTIONAL FOODS
LA English
DT Review
DE Soy milk; Cardiometabolic disease; Systematic review; Meta-analysis
ID TYPE-2 DIABETIC-PATIENTS; CARDIOVASCULAR-DISEASE; BLOOD-PRESSURE;
   OXIDATIVE STRESS; SOYMILK SUPPLEMENTATION; WAIST CIRCUMFERENCE;
   PLASMA-LIPIDS; CROSS-OVER; TNF-ALPHA; COWS MILK
AB Background: Soy milk contains some beneficial components such as isoflavones which can exert favorable effects on the cardiovascular health. The current study aimed to comprehensively evaluate the potential effects of soy milk consumption on cardiometabolic risk factors in adults. Methods: Relevant articles published up to June 2020 were systematically retrieved from SCOPUS, PubMed/ MEDLINE, EMBASE, and Web of Science databases. In our study, we included all the randomized controlled trials (RCTs) investigating the impact of soy milk consumption on various cardiometabolic risk factors in adults (age >= 18 years). A meta-analysis of the eligible studies was performed using the random-effects model. Results: The quantitative meta-analysis of 18 eligible RCTs (665 participants, age range 18-65 years) demonstrated that the consumption of soy milk significantly reduced systolic (P < 0.001) and diastolic (P = 0.002) blood pressure, total (P = 0.001) and low-density lipoprotein (P = 0.041) cholesterol, waist circumference (P = 0.005), C-reactive protein (P < 0.001), and tumor necrosis factor-alpha (P = 0.016). Significant between-study heterogeneity was found for the pooled effect sizes of blood pressure and low-density lipoprotein cholesterol. In addition, the subgroup analyses indicated that the decrease in systolic blood pressure (SBP) was more pronounced when soy milk was consumed for <= 4 weeks. However, there were no significant differences between soy milk and control groups for the other factors, namely body weight, body mass index (BMI), high-density lipoprotein cholesterol, triglycerides, fasting blood glucose (FBG), and fasting insulin, interleukin-6, and fibrinogen. Conclusions: The current systematic review and meta-analysis revealed that incorporating soy milk into the diet might favorably affect several cardiometabolic risk factors in both healthy and unhealthy individuals.
C1 [Sohouli, Mohammad Hassan; Fatahi, Somaye] Iran Univ Med Sci, Fac Publ Hlth Branch, Student Res Comm, Tehran, Iran.
   [Sohouli, Mohammad Hassan; Lari, Abolfazl; Shidfar, Farzad] Iran Univ Med Sci, Sch Publ Hlth, Dept Nutr, Tehran, Iran.
   [Fatahi, Somaye] Shahid Beheshti Univ Med Sci, Res Inst Childrens Hlth, Pediat Gastroenterol Hepatol & Nutr Res Ctr, Tehran, Iran.
   [Gaman, Mihnea-Alexandru] Carol Davila Univ Med & Pharm, Fac Med, Bucharest, Romania.
   [Gaman, Mihnea-Alexandru] Fundeni Clin Inst, Ctr Hematol & Bone Marrow Transplantat, Dept Hematol, Bucharest, Romania.
   [Guimaraes, Nathalia Sernizon] Univ Fed Ouro Preto, Dept Nutr, Ouro Preto, MG, Brazil.
   [Sindi, Ghufran Abdullatif; Mandili, Rasha Abdulaziz; Alzahrani, Ghaida Rashed; Abdulwahab, Rahaf Abdulrashid; Almuflihi, Alhanouf Mohammed] Umm Al Qura Univ, Coll Med, Mecca, Saudi Arabia.
   [Alsobyani, Faris Mohammed; Mahmud, Amna Malik Albu; Nazzal, Osama; Alshaibani, Lama] Arabian Gulf Univ, Coll Med & Med Sci, Manama, Bahrain.
   [Elmokid, Shouq; Abu-Zaid, Ahmed] Alfaisal Univ, Coll Med, Riyadh, Saudi Arabia.
C3 Iran University of Medical Sciences; Iran University of Medical
   Sciences; Shahid Beheshti University Medical Sciences; Carol Davila
   University of Medicine & Pharmacy; Institutul Clinic Fundeni;
   Universidade Federal de Ouro Preto; Umm Al-Qura University; Arabian Gulf
   University; Alfaisal University
RP Shidfar, F (corresponding author), Iran Univ Med Sci, Sch Publ Hlth, Dept Nutr, Tehran, Iran.
EM shidfar.f@iums.ac.ir
RI Shidfar, Farzad/H-6651-2018; Ahmed, Ahmed/JHS-7565-2023; Gaman,
   Mihnea-Alexandru/O-4258-2016
OI Gaman, Mihnea-Alexandru/0000-0001-7133-8875
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NR 77
TC 13
Z9 14
U1 2
U2 20
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1756-4646
EI 2214-9414
J9 J FUNCT FOODS
JI J. Funct. Food.
PD AUG
PY 2021
VL 83
AR 104499
DI 10.1016/j.jff.2021.104499
EA MAY 2021
PG 13
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA UD8NK
UT WOS:000687459400010
OA gold
DA 2025-06-11
ER

PT J
AU Guay, A
   Seftel, AD
   Traish, A
AF Guay, A.
   Seftel, A. D.
   Traish, A.
TI Hypogonadism in men with erectile dysfunction may be related to a host
   of chronic illnesses
SO INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH
LA English
DT Article
DE hypogonadism; testosterone deficiency; chronic illness; work stresses
ID ENDOGENOUS SEX-HORMONES; TRANSIENT HYPOGONADOTROPIC HYPOGONADISM;
   SYMPTOMATIC ANDROGEN DEFICIENCY; LIFE-STYLE FACTORS; MIDDLE-AGED MEN;
   TESTOSTERONE LEVELS; METABOLIC SYNDROME; OLDER MEN; SECONDARY
   HYPOGONADISM; IMMOBILIZATION STRESS
AB The prevalence of hypogonadism has been found to be increased in certain chronic illnesses, especially diabetes, hypertension and obesity. Recently, the prevalence of hypogonadism in primary care practices mirrored that in our population of men with erectile dysfunction (ED). In this study, the prevalence of hypogonadism in nearly 1000 men with ED was tabulated, using a retrospective chart review, and analyzed for association with the various contributing medical and psychological factors. The prevalence of hypogonadism was determined in men with a variety of chronic illnesses, and was further characterized by decade. We observed an association between hypertension (P=0.025), tobacco abuse (P=0.0059), sleep apnea (P=0.0001), work stress (P=0.041) and hypogonadism. These data were further analyzed for the odds ratio and confidence interval (Forest plot), which showed strong association for sleep apnea and work stress. We did not observe any significant association between diabetes, atherosclerosis, alcohol abuse, multiple medications, asthma, seizure disorder, anxiety/depression and hypogonadism (P values for Cochran-Mantel-Haenszel general association were 0.48, 0.97, 0.25, 0.69, 0.22, 0.76 and 0.98, respectively). We suggest that a host of chronic illnesses have a high prevalence of secondary hypogonadism. Men who have chronic medical or psychological illnesses should have their testosterone level checked, especially when sexual dysfunction symptoms or signs are present. International Journal of Impotence Research (2010) 22, 9-19; doi:10.1038/ijir.2009.46; published online 1 October 2009
C1 [Guay, A.] Lahey Clin Northshore, Dept Endocrinol, Ctr Sexual Funct, Peabody, MA 01960 USA.
   [Seftel, A. D.] Case Western Reserve Univ, Dept Urol & Reprod Biol, Cleveland, OH 44106 USA.
   [Traish, A.] Boston Univ, Sch Med, Dept Biochem, Boston, MA 02118 USA.
   [Traish, A.] Boston Univ, Sch Med, Dept Urol, Boston, MA 02118 USA.
C3 Lahey Hospital & Medical Center; University System of Ohio; Case Western
   Reserve University; Boston University; Boston University
RP Guay, A (corresponding author), Lahey Clin Northshore, Dept Endocrinol, Ctr Sexual Funct, 1 Essex Ctr, Peabody, MA 01960 USA.
EM andre.t.guay@lahey.org
FU Department of Endocrinology, Lahey Clinic, the Department of Urology,
   Case Western Reserve University; Department of Urology, Boston
   University School of Medicine
FX This work was solely supported by the Department of Endocrinology, Lahey
   Clinic, the Department of Urology, Case Western Reserve University and
   the Department of Urology, Boston University School of Medicine.
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NR 58
TC 29
Z9 30
U1 0
U2 4
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0955-9930
EI 1476-5489
J9 INT J IMPOT RES
JI Int. J. Impot. Res.
PD JAN
PY 2010
VL 22
IS 1
BP 9
EP 19
DI 10.1038/ijir.2009.46
PG 11
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 543IA
UT WOS:000273566600002
PM 19798059
DA 2025-06-11
ER

PT J
AU Zamora, AN
   Marchlewicz, E
   Téllez-Rojo, MM
   Burant, CF
   Cantoral, A
   Song, PXK
   Mercado, A
   Dolinoy, DC
   Peterson, KE
AF Zamora, Astrid N.
   Marchlewicz, Elizabeth
   Tellez-Rojo, Martha M.
   Burant, Charles F.
   Cantoral, Alejandra
   Song, Peter X. K.
   Mercado, Adriana
   Dolinoy, Dana C.
   Peterson, Karen E.
TI Trimester two gestational exposure to bisphenol A and adherence to
   mediterranean diet are associated with adolescent offspring oxidative
   stress and metabolic syndrome risk in a sex-specific manner
SO FRONTIERS IN NUTRITION
LA English
DT Article
DE adolescent health; bisphenol A; early-life exposures; mediterranean diet
   score; metabolic syndrome risk; oxidative stress
ID BODY-MASS INDEX; PRENATAL BPA EXPOSURE; PHYSICAL-ACTIVITY; BIRTH-WEIGHT;
   MATERNAL OBESITY; BLOOD-PRESSURE; IN-UTERO; PREGNANCY; INSULIN; CHILD
AB BackgroundExposure to prenatal bisphenol A (BPA) and Mediterranean Diet Score (MDS) has been linked to metabolic risk in child offspring. It remains unclear if independent and interactive effects persist in adolescence. MethodsWe examined prenatal BPA and MDS on adolescent offspring metabolic syndrome risk score (MRS) and 8-isoprostane (8-iso), a biomarker of oxidative stress. Data from maternal-adolescent dyads from a Mexico City cohort were utilized, including trimester-specific prenatal BPA from spot urine and MDS from food frequency questionnaires. Offspring socio-demographic data and biomarkers to estimate MRS and 8-iso were obtained during peri-adolescence. ResultsAdjusted linear regression models examined associations between trimester-specific BPA, MDS, and BPA*MDS on outcomes. Sex-stratified analyses revealed a significant association between MDS with increased 8-iso (beta = 0.064, p < 0.05), and a marginal association between trimester two BPA with increased 8-iso (beta = 0.237), while MDS modified the marginal association between BPA and 8-iso in females (beta = 0.046). A negative, marginal association was observed between trimester two BPA and MRS (beta = - 0.728), while BPA * MDS was marginally, positively associated with MRS (beta = 0.152) in males. ConclusionsStudy findings indicate that trimester two prenatal BPA and maternal adherence to a Mediterranean diet may have sexually dimorphic effects on adolescent offspring oxidative stress and metabolic syndrome risk.
C1 [Zamora, Astrid N.; Burant, Charles F.; Dolinoy, Dana C.; Peterson, Karen E.] Univ Michigan, Sch Publ Hlth, Dept Nutr Sci, Ann Arbor, MI 48109 USA.
   [Marchlewicz, Elizabeth; Dolinoy, Dana C.; Peterson, Karen E.] Univ Michigan, Sch Publ Hlth, Dept Environm Hlth Sci, Ann Arbor, MI 48109 USA.
   [Tellez-Rojo, Martha M.; Mercado, Adriana] Natl Inst Publ Hlth, Ctr Res Nutr & Hlth, Cuernavaca, Morelos, Mexico.
   [Burant, Charles F.] Michigan Med, Dept Internal Med, Ann Arbor, MI USA.
   [Cantoral, Alejandra] Iberoamer Univ, Hlth Dept, Mexico City, DF, Mexico.
   [Song, Peter X. K.] Univ Michigan, Sch Publ Hlth, Dept Biostat, Ann Arbor, MI 48109 USA.
C3 University of Michigan System; University of Michigan; University of
   Michigan System; University of Michigan; Instituto Nacional de Salud
   Publica; Universidad Iberoamericana Ciudad de Mexico; University of
   Michigan System; University of Michigan
RP Téllez-Rojo, MM (corresponding author), Natl Inst Publ Hlth, Ctr Res Nutr & Hlth, Cuernavaca, Morelos, Mexico.
EM mmtellez@insp.mx
RI Zamora, Astrid/HHC-7654-2022; Cantoral, Alejandra/AAA-3615-2021
OI Burant, Charles/0000-0001-9189-5003; Zamora, Astrid/0000-0001-8187-3492
FU Eunice Kennedy Shriver National Institute of Child Health and Human
   Development [T32HD079342] Funding Source: NIH RePORTER; National
   Institute of Diabetes and Digestive and Kidney Diseases [P30DK089503]
   Funding Source: NIH RePORTER; National Institute of Environmental Health
   Sciences [P30ES017885, R35ES031686] Funding Source: NIH RePORTER
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NR 85
TC 1
Z9 1
U1 1
U2 10
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD OCT 5
PY 2022
VL 9
AR 961082
DI 10.3389/fnut.2022.961082
PG 14
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 5N0NK
UT WOS:000871487900001
PM 36276834
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Sueta, D
   Nakamura, T
   Dong, YF
   Kataoka, K
   Koibuchi, N
   Yamamoto, E
   Toyama, K
   Yasuda, O
   Ogawa, H
   Kim-Mitsuyama, S
AF Sueta, Daisuke
   Nakamura, Taishi
   Dong, Yi-Fei
   Kataoka, Keiichiro
   Koibuchi, Nobutaka
   Yamamoto, Eiichiro
   Toyama, Kensuke
   Yasuda, Osamu
   Ogawa, Hisao
   Kim-Mitsuyama, Shokei
TI Amlodipine Enhances Amelioration of Vascular Insulin Resistance,
   Oxidative Stress, and Metabolic Disorders by Candesartan in Metabolic
   Syndrome Rats
SO AMERICAN JOURNAL OF HYPERTENSION
LA English
DT Article
DE blood pressure; combination therapy; hypertension; inflammation;
   obesity; oxidative stress; vascular insulin resistance
ID ENDOTHELIAL DYSFUNCTION; CORONARY MICROVESSELS; CARDIOVASCULAR EVENTS;
   HYPERTENSIVE PATIENTS; ADIPOSE-TISSUE; NITRIC-OXIDE;
   HYDROCHLOROTHIAZIDE; NEPHROPATHY; NIFEDIPINE; EXPRESSION
AB BACKGROUND
   The pharmacological advantage of combination of an angiotensin receptor blocker (ARB) and a calcium-channel blocker (CCB) is not fully defined. This study was undertaken to elucidate the potential benefit of their combination in metabolic syndrome.
   METHODS
   SHR/NDmcr-cp (SHRcp), a rat model of human metabolic syndrome, were divided into four groups, and were administered (i) vehicle, (ii) candesartan (an ARB) 0.3 mg/kg/day, (iii) amlodipine (a CCB) 3 mg/kg/day, and (iv) candesartan 0.3 mg/kg/day plus amlodipine 3 mg/kg/day, for 4 weeks.
   RESULTS
   Candesartan, amlodipine, or their combination significantly ameliorated the impairment of vascular endothelium-dependent relaxation with acetylcholine in SHRcp. However, the impairment of insulin-induced vasodilation in SHRcp was partially improved by candesartan alone, but not by amlodipine alone. Interestingly, amlodipine added to candesartan synergistically enhanced the improvement of impaired insulin-induced vasodilation by candesartan, indicating the synergistic improvement of vascular insulin resistance by the combination of these drugs. Candesartan alone, but not amlodipine alone, significantly attenuated vascular superoxide and NADPH oxidase subunit p22phox in SHRcp. Amlodipine added to candesartan synergistically enhanced the reduction of vascular p22phox levels and superoxide by candesartan in SHRcp, suggesting the association of vascular insulin resistance with oxidative stress. Furthermore, the combination of candesartan with amlodipine synergistically decreased the increase in visceral adipocyte size, serum free-fatty acid, and tumor necrosis factor-a in SHRcp.
   CONCLUSIONS
   ARB and CCB combination synergistically ameliorated vascular insulin resistance in metabolic syndrome, being associated with the synergistic attenuation of vascular oxidative stress and metabolic disorders.
C1 [Sueta, Daisuke; Nakamura, Taishi; Dong, Yi-Fei; Kataoka, Keiichiro; Koibuchi, Nobutaka; Yamamoto, Eiichiro; Toyama, Kensuke; Kim-Mitsuyama, Shokei] Kumamoto Univ, Grad Sch Med Sci, Dept Pharmacol & Mol Therapeut, Kumamoto, Japan.
   [Dong, Yi-Fei] Nanchang Univ, Affiliated Hosp 2, Dept Cardiovasc Med, Nanchang, Peoples R China.
   [Yasuda, Osamu] Kumamoto Univ Hosp, Dept Cardiovasc Clin & Translat Res, Kumamoto, Japan.
   [Ogawa, Hisao] Kumamoto Univ, Grad Sch Med Sci, Dept Cardiovasc Med, Kumamoto, Japan.
C3 Kumamoto University; Nanchang University; Kumamoto University; Kumamoto
   University
RP Kim-Mitsuyama, S (corresponding author), Kumamoto Univ, Grad Sch Med Sci, Dept Pharmacol & Mol Therapeut, Kumamoto, Japan.
EM kimmitsu@gpo.kumamoto-u.ac.jp
RI Sueta, Daisuke/ABG-9809-2021; Nakamura, Taishi/O-9297-2019
FU Ministry of Education, Culture, Sports, Science, and Technology;
   Grants-in-Aid for Scientific Research [23590886] Funding Source: KAKEN
FX This work was supported by Grants-in-Aid for Scientific Research from
   the Ministry of Education, Culture, Sports, Science, and Technology. We
   thank Miho Kataoka, Michie Uchikawa, Sawako Nagai, Keiko Morozumi,
   Yuriko Shimamura, Noriko Yoshimura, Kazuko Noda, and Tomoko Moriyama for
   their kind supports during the study.
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NR 31
TC 14
Z9 15
U1 0
U2 2
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0895-7061
EI 1941-7225
J9 AM J HYPERTENS
JI Am. J. Hypertens.
PD JUN
PY 2012
VL 25
IS 6
BP 704
EP 710
DI 10.1038/ajh.2012.26
PG 7
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 944GZ
UT WOS:000304188600014
PM 22421905
OA Bronze
DA 2025-06-11
ER

PT J
AU Subramanian, S
   Goodspeed, L
   Wang, SR
   Kim, J
   Zeng, LX
   Ioannou, GN
   Haigh, WG
   Yeh, MM
   Kowdley, KV
   O'Brien, KD
   Pennathur, S
   Chait, A
AF Subramanian, Savitha
   Goodspeed, Leela
   Wang, Shari
   Kim, Jinkyu
   Zeng, Lixia
   Ioannou, George N.
   Haigh, W. Geoffrey
   Yeh, Matthew M.
   Kowdley, Kris V.
   O'Brien, Kevin D.
   Pennathur, Subramaniam
   Chait, Alan
TI Dietary cholesterol exacerbates hepatic steatosis and inflammation in
   obese LDL receptor-deficient mice
SO JOURNAL OF LIPID RESEARCH
LA English
DT Article
DE fatty liver; metabolic syndrome; oxysterols; apoptosis; oxidative
   stress; low density lipoprotein; oxidized fatty acids
ID FATTY LIVER-DISEASE; NONALCOHOLIC STEATOHEPATITIS; OXIDATIVE STRESS;
   INSULIN-RESISTANCE; GENE-EXPRESSION; MACROPHAGE ACCUMULATION;
   LIPID-PEROXIDATION; ATHEROGENIC DIET; ANIMAL-TISSUES; ADIPOSE-TISSUE
AB Non-alcoholic fatty liver disease (NAFLD), the hepatic manifestation of the metabolic syndrome, can progress to steatohepatitis (NASH) and advanced liver disease. Mechanisms that underlie this progression remain poorly understood, partly due to lack of good animal models that resemble human NASH. We previously showed that several metabolic syndrome features that develop in LDL receptor-deficient (LDLR-/-) mice fed a diabetogenic diet are worsened by dietary cholesterol. To test whether dietary cholesterol can alter the hepatic phenotype in the metabolic syndrome, we fed LDLR-/- mice a high-fat, high-carbohydrate diabetogenic diet (DD) without or with added cholesterol (DDC). Both groups of mice developed obesity and insulin resistance. Hyperinsulinemia, dyslipidemia, hepatic triglyceride, and alanine aminotransferase (ALT) elevations were greater with DDC. Livers of DD-fed mice showed histological changes resembling NAFLD, including steatosis and modest fibrotic changes; however, DDC-fed animals developed micro-and macrovesicular steatosis, inflammatory cell foci, and fibrosis resembling human NASH. Dietary cholesterol also exacerbated hepatic macrophage infiltration, apoptosis, and oxidative stress. Thus, LDLR-/- mice fed diabetogenic diets may be useful models for studying human NASH. Dietary cholesterol appears to confer a second "hit" that results in a distinct hepatic phenotype characterized by increased inflammation and oxidative stress.-Subramanian, S., L. Goodspeed, S. Wang, J. Kim, L. Zeng, G. N. Ioannou, W. G. Haigh, M. M. Yeh, K. V. Kowdley, K. D. O'Brien, S. Pennathur, and A. Chait. Dietary cholesterol exacerbates hepatic steatosis and inflammation in obese LDL receptor-deficient mice. J. Lipid Res. 2011. 52: 1626-1635.
C1 [Subramanian, Savitha; Goodspeed, Leela; Wang, Shari; Chait, Alan] Univ Washington, Diabet & Obes Ctr Excellence, Seattle, WA 98195 USA.
   [Subramanian, Savitha; Goodspeed, Leela; Wang, Shari; Chait, Alan] Univ Washington, Dept Med, Div Metab Endocrinol & Nutr, Seattle, WA 98195 USA.
   [Kim, Jinkyu; O'Brien, Kevin D.] Univ Washington, Dept Med, Div Cardiol, Seattle, WA 98195 USA.
   [Ioannou, George N.; Haigh, W. Geoffrey; Kowdley, Kris V.] Univ Washington, Dept Med, Div Gastroenterol, Seattle, WA 98195 USA.
   [Yeh, Matthew M.] Univ Washington, Dept Pathol, Seattle, WA 98195 USA.
   [Zeng, Lixia; Pennathur, Subramaniam] Univ Michigan, Dept Internal Med, Div Nephrol, Sch Med, Ann Arbor, MI 48109 USA.
C3 University of Washington; University of Washington Seattle; University
   of Washington; University of Washington Seattle; University of
   Washington; University of Washington Seattle; University of Washington;
   University of Washington Seattle; University of Washington; University
   of Washington Seattle; University of Michigan System; University of
   Michigan
RP Subramanian, S (corresponding author), Univ Washington, Diabet & Obes Ctr Excellence, Seattle, WA 98195 USA.
EM ssubrama@u.washington.edu
RI Pennathur, Subramaniam/O-7032-2017; Kowdley, Kris/AAF-5202-2019;
   O'Brien, Kevin/HDO-1461-2022
OI Subramanian, Savitha/0000-0002-4866-2009; O'Brien,
   Kevin/0000-0002-2293-9196; Pennathur, Subramaniam/0000-0003-3628-6883
FU National Institutes of Health [P30 DK-035816, P01 HL-092969, DK-082841,
   DK-089503]; mentor-based American Diabetes Association; National
   Institute of Diabetes and Digestive and Kidney Diseases [P30DK089503]
   Funding Source: NIH RePORTER
FX This work was supported by National Institutes of Health Grants P30
   DK-035816 (A. C. and S. S.), P01 HL-092969 (A. C.), DK-082841 (S. P.),
   DK-089503 (S. P.), and a mentor-based American Diabetes Association
   postdoctoral fellowship award (S. S.). Its contents are solely the
   responsibility of the authors and do not necessarily represent the
   official views of the National Institutes of Health.
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NR 49
TC 194
Z9 213
U1 2
U2 25
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0022-2275
EI 1539-7262
J9 J LIPID RES
JI J. Lipid Res.
PD SEP
PY 2011
VL 52
IS 9
BP 1626
EP 1635
DI 10.1194/jlr.M016246
PG 10
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 806RL
UT WOS:000293827600003
PM 21690266
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Karin, M
   Kim, JY
AF Karin, Michael
   Kim, Ju Youn
TI MASH as an emerging cause of hepatocellular carcinoma: current knowledge
   and future perspectives
SO MOLECULAR ONCOLOGY
LA English
DT Review
DE ER stress; genetic mutation; Hepatocellular carcinoma; inflammation;
   lipotoxicity; MASH; metabolic syndrome; obesity
ID FATTY LIVER-DISEASE; NECROSIS-FACTOR-ALPHA; UNFOLDED PROTEIN RESPONSE;
   RETICULUM STRESS-RESPONSE; KAPPA-B KINASE; NONALCOHOLIC STEATOHEPATITIS;
   ENDOPLASMIC-RETICULUM; ER STRESS; INSULIN-RESISTANCE; METABOLIC SYNDROME
AB Hepatocellular carcinoma is one of the deadliest and fastest-growing cancers. Among HCC etiologies, metabolic dysfunction-associated fatty liver disease (MAFLD) has served as a major HCC driver due to its great potential for increasing cirrhosis. The obesogenic environment fosters a positive energy balance and results in a continuous rise of obesity and metabolic syndrome. However, it is difficult to understand how metabolic complications lead to the poor prognosis of liver diseases and which molecular mechanisms are underpinning MAFLD-driven HCC development. Thus, suitable preclinical models that recapitulate human etiologies are essentially required. Numerous preclinical models have been created but not many mimicked anthropometric measures and the course of disease progression shown in the patients. Here we review the literature on adipose tissues, liver-related HCC etiologies and recently discovered genetic mutation signatures found in MAFLD-driven HCC patients. We also critically review current rodent models suggested for MAFLD-driven HCC study.
C1 [Karin, Michael] Univ Calif San Diego, Sch Med, Dept Pharmacol & Pathol, Lab Gene Regulat & Signal Transduct, La Jolla, CA USA.
   [Kim, Ju Youn] Hanyang Univ ERICA, Dept Mol & Life Sci, Ansan 15588, South Korea.
C3 University of California System; University of California San Diego;
   Hanyang University
RP Kim, JY (corresponding author), Hanyang Univ ERICA, Dept Mol & Life Sci, Ansan 15588, South Korea.
EM juyounkim@hanyang.ac.kr
OI Karin, Michael/0000-0002-2758-6473
FU Korea National Institute of Health; Prevent Cancer Foundation
   [RS-2023-00253419]; National Research Foundation of Korea (NRF) - Korea
   government (MSIT) [HY-2023-0529]; Hanyang University [R01DK120714];
   National Institutes of Health
FX This research was supported by the Prevent Cancer Foundation, the
   National Research Foundation of Korea (NRF) funded by the Korea
   government (MSIT) (RS-2023-00253419) and the research fund of Hanyang
   University (HY-2023-0529) to JYK, and (National Institutes of Health
   R01DK120714) to MK. We particularly appreciate Lily, Q. Wang (Scripps
   Research Institute, CA) for editing the manuscript.
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NR 225
TC 4
Z9 4
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1574-7891
EI 1878-0261
J9 MOL ONCOL
JI Mol. Oncol.
PD FEB
PY 2025
VL 19
IS 2
BP 275
EP 294
DI 10.1002/1878-0261.13685
EA JUN 2024
PG 20
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA U8B0N
UT WOS:001247453000001
PM 38874196
OA gold
DA 2025-06-11
ER

PT J
AU Yamada, J
   Tomiyama, H
   Yambe, M
   Koji, Y
   Motobe, K
   Shiina, K
   Yamamoto, Y
   Yamashina, A
AF Yamada, Jiko
   Tomiyama, Hirofumi
   Yambe, Minoru
   Koji, Yutaka
   Motobe, Kohki
   Shiina, Kazuki
   Yamamoto, Yoshio
   Yamashina, Akira
TI Elevated serum levels of alanine aminotransferase and gamma
   glutamyltransferase are markers of inflammation and oxidative stress
   independent of the metabolic syndrome
SO ATHEROSCLEROSIS
LA English
DT Article
DE metabolic syndrome; fatty liver; inflammation; oxidative stress
ID C-REACTIVE PROTEIN; NONALCOHOLIC FATTY LIVER; PULSE-WAVE VELOCITY;
   INSULIN-RESISTANCE; CARDIOVASCULAR RISK; ARTERIAL STIFFNESS;
   ASSOCIATION; DISEASE; ATHEROSCLEROSIS; WOMEN
AB The present study attempted to establish whether elevated serum levels of alanine aminotransferase (ALT) and gamma glutamyltransferase (GGT) are independent (of each other) markers of systemic inflammation and oxidative stress as assessed by the plasma levels of C-reactive protein (CRP) and lipid peroxides (lipOX), regardless of the presence of underlying metabolic syndrome (as defined by the modified Adult Treatment Panel III (ATPIII) criteria). The plasma levels of CRP and lipOX were determined in 1483 middle-age Japanese men (42 9 years). A general linear model analysis indicated that elevated serum ALT and/or serum GGT (levels in the respective highest quartiles) were significantly related to the logarithms of the plasma levels of CRP (Beta = 0.08 (0.05-0.11) and 0.08 (0.05-0.11), respectively) and the logarithm of the plasma levels of lipOX (Beta=0.03 (0.01-0.05) and 0.03 (0.01-0.05), respectively), regardless of the presence of underlying metabolic syndrome (MetS) (p < 0.01). In addition, the presence of MetS and elevated serum levels of both of these liver enzymes additively increased the plasma levels of CRP and lipOX. Thus, it is proposed that elevated serum ALT and elevated serum GGT are independent markers of the activation of systemic inflammation and increased oxidative stress, independent of their relationship to MetS, and that the presence of MetS and elevations of both of these liver enzymes may additively worsen the atherogenic state. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
C1 Tokyo Med Univ, Dept Internal Med 2, Shinjuku Ku, Tokyo 1600023, Japan.
   Kajima Corp, Hlth Care Ctr, Tokyo, Japan.
C3 Tokyo Medical University; Kajima Corporation
RP Tomiyama, H (corresponding author), Tokyo Med Univ, Dept Internal Med 2, Shinjuku Ku, 6-7-1 Nishi Shinjuku, Tokyo 1600023, Japan.
EM tomiyama@tokyo-med.ac.jp
OI Shiina, Kazuki/0000-0002-7293-2064
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NR 34
TC 197
Z9 210
U1 0
U2 12
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0021-9150
J9 ATHEROSCLEROSIS
JI Atherosclerosis
PD NOV
PY 2006
VL 189
IS 1
BP 198
EP 205
DI 10.1016/j.atherosclerosis.2005.11.036
PG 8
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 097SD
UT WOS:000241467900025
PM 16405892
DA 2025-06-11
ER

PT J
AU Mariman, JJ
   Vergara, RC
   San Martin, C
   Zapata, V
   Arteaga, O
   Delano, PH
   Derio, CD
AF Mariman, Juan Jose
   Vergara, Rodrigo C.
   San Martin, Consuelo
   Zapata, Victor
   Arteaga, Oscar
   Delano, Paul H.
   Derio, Carolina Delgado
TI Modifiable dementia risk factors in Chilean adults are distinctively
   associated with social determinants of health. Cross-sectional study
SO BMC PUBLIC HEALTH
LA English
DT Article
DE Dementia; Prevention; Risk factors; Clusters; Latin America; Metabolic;
   Cardiovascular; Behavioral; Depression; Socioeconomic; Multimorbidity
ID POPULATION ATTRIBUTABLE FRACTIONS; PREVENTION; COUNTRIES
AB BackgroundIn Latin America, dementia cases will double by 2050. For effective prevention in this region, it is crucial to comprehend the distribution of dementia risk factors within the local population and to assess their association with social determinants of health (SDH). Our objective was to explore the association between different modifiable dementia risk factors within the Chilean population in a cross-sectional study.Methods3379 dementia-free subjects >= 45 years old from the 2016-2017 Chilean National Health Survey were analyzed and stratified into four groups by sex and age, searching for clusters using six continuous variables that had been related to dementia risk (years of education, systolic blood pressure, body mass index (BMI), units of alcohol consumption, physical activity, and depressive symptoms).ResultsThree clusters of individuals shared similar risk factors in each sex/age group. A cluster with high cardiometabolic risk was present in all sex/age groups, characterized by high systolic blood pressure (HSBP) in men midlife and by HSBP associated with high BMI (HSBP/HBMI) in women and in men later-life. A depressive cluster and a physically inactive cluster were present in 3 & frasl;4 of the sex/age groups. Additionally, there was a cluster that was relatively healthy but had a risk of excessive alcohol consumption in men later-life and a low risk one in women midlife. The HSBP/HBMI and depressive clusters presented a high proportion of multiple dementia risk factors. Lower levels of education (and lower family income) were associated with the HSBP and HSBP/HBMI cluster; in contrast, higher levels of education were associated with clusters with lower risk.ConclusionIn Chile, subpopulations with more disadvantages SDH have a high prevalence of cardiometabolic risk factors. Subpopulations with depression and those with high cardiometabolic risk have a higher accumulation of dementia risk factors. These results highlight that tailored programs improving healthcare accessibility for those with more disadvantages SDH and multidisciplinary interventions for high-risk populations are needed for effective dementia prevention.
C1 [Mariman, Juan Jose] Univ Metropolitana Ciencias Educ, Ctr Invest CEI UMCE, Santiago, Chile.
   [Mariman, Juan Jose; Vergara, Rodrigo C.] Univ Metropolitana Ciencias Educ, Fac Artes & Educ Fis, Dept Kinesiol, Santiago, Chile.
   [Mariman, Juan Jose] Univ Chile, Fac Med, Dept Kinesiol, Santiago, Chile.
   [Vergara, Rodrigo C.] Ctr Nacl Inteligencia Artificial, Santiago, Chile.
   [San Martin, Consuelo] Univ Andes, Escuela Psicol, Santiago, Chile.
   [Zapata, Victor] Hosp Clin Univ Chile, Gerencia Operac, Santiago, Chile.
   [Arteaga, Oscar] Univ Chile, Escuela Salud Publ, Fac Med, Santiago, Chile.
   [Delano, Paul H.] Hosp Clin Univ Chile, Serv Otorrinolaringol, Santiago, Chile.
   [Delano, Paul H.] Univ Tecn Federico Santa Maria, Ctr Avanzado Ingn Elect & Elect, AC3E, Santiago, Chile.
   [Delano, Paul H.; Derio, Carolina Delgado] Univ Chile, Fac Med, Dept Neurociencia, Santiago, Chile.
   [Derio, Carolina Delgado] Univ Chile, Hosp Clin, Dept Neurol & Neurocirugia, Unidad Cerebro Saludable, Santiago, Chile.
C3 Universidad Metropolitana de Ciencias de la Educacion (UMCE);
   Universidad Metropolitana de Ciencias de la Educacion (UMCE);
   Universidad de Chile; Universidad de los Andes - Chile; Universidad de
   Chile; Universidad de Chile; Universidad de Chile; Universidad Tecnica
   Federico Santa Maria; Universidad de Chile; Universidad de Chile
RP Derio, CD (corresponding author), Univ Chile, Fac Med, Dept Neurociencia, Santiago, Chile.; Derio, CD (corresponding author), Univ Chile, Hosp Clin, Dept Neurol & Neurocirugia, Unidad Cerebro Saludable, Santiago, Chile.
EM cdelgado@uchile.cl
RI Delano, Paul/I-1030-2013; Mariman, Juan José/GQB-5564-2022; Arteaga,
   Oscar/N-9925-2018
OI Mariman, Juan Jose/0000-0002-4424-1004
FU Alzheimer Association [SG-21-815077LatAm FINGERS - Chile]; Agencia
   Nacional de Investigacion y Desarrollo (ANID) de Chile [ID21I10096];
   FONDECYT [3200153, ID11221226, 1220607, FB0008]; Fundacion Puelma;
   Centro Nacional de Inteligencia Artificial CENIA [FB210017]; ANID + InES
   Genero [INGE210028]
FX This work was partially supported by the Alzheimer Association
   (SG-21-815077LatAm FINGERS - Chile) to CD and Agencia Nacional de
   Investigacion y Desarrollo (ANID) de Chile (grant numbers ID21I10096 to
   CD, FONDECYT postdoctoral 3200153 to CSM, FONDECYT ID11221226 to JM,
   FONDECYT 1220607, FB0008 and Fundacion Puelma to PHD, Centro Nacional de
   Inteligencia Artificial CENIA, FB210017, to RV and the ANID + InES
   Genero (INGE210028) to CD.
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TC 0
Z9 0
U1 2
U2 2
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2458
J9 BMC PUBLIC HEALTH
JI BMC Public Health
PD MAR 24
PY 2025
VL 25
IS 1
AR 1117
DI 10.1186/s12889-025-22220-6
PG 15
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA 0MW7V
UT WOS:001451155800003
PM 40128675
OA gold
DA 2025-06-11
ER

PT S
AU Kyrou, I
   Chrousos, GP
   Tsigos, C
AF Kyrou, Ioannis
   Chrousos, George P.
   Tsigos, Constantine
BE Chrousos, GP
   Tsigos, C
TI Stress, visceral obesity, and metabolic complications
SO STRESS, OBESITY, AND METABOLIC SYNDROME
SE Annals of the New York Academy of Sciences
LA English
DT Article; Proceedings Paper
CT Bjorntorp Symposium on Stress, Obesity, and Metabolic Syndrome
CY APR 09-10, 2005
CL Athens, GREECE
SP Roche Hellas, Abbott Hellas, Pfizer Hellas, Sanofi Aventis Hellas, GlaxoSmithKline Hellas
DE stress; HPA axis; glucocorticoids; cytokines; obesity; metabolic
   syndrome
ID CORTICOTROPIN-RELEASING-FACTOR; PITUITARY-ADRENAL AXIS; RECOMBINANT
   HUMAN INTERLEUKIN-6; CENTRAL-NERVOUS-SYSTEM; GROWTH-HORMONE-SECRETION;
   RECEPTOR MESSENGER-RNA; ADRENOCORTICOTROPIN RELEASE;
   GLUCOCORTICOID-RECEPTOR; GENE-EXPRESSION; SUBSTANCE-P
AB Stress is a state of threatened homeostasis or disharmony caused by intrinsic or extrinsic adverse forces and is counteracted by an intricate repertoire of physiologic and behavioral responses that aim to reestablish the challenged body equilibrium. The adaptive stress response depends upon an elaborate neuroendocrine, cellular, and molecular infrastructure, the stress system. Crucial functions of the stress system response are mediated by the hypothalamic-pituitary-adrenal (HPA) axis and the central and peripheral components of the autonomic nervous system (ANS). The integrity of the HPA axis and the ANS and their precise interactions with other CNS components are essential for a successful response to the various stressors. Chronic stress represents a prolonged threat to homeostasis by persistent or frequently repeated stressors and may lead to manifestations that characterize a wide range of diseases and syndromes. Such states progressively lead to a deleterious overload with complications caused by both the persistent stressor and the detrimental prolongation of the adaptive response. The metabolic syndrome can be described as a state of deranged metabolic homeostasis characterized by the combination of central obesity, insulin resistance, dyslipidemia, and hypertension. The incidence of both obesity and the metabolic syndrome in modern Western societies has taken epidemic proportions over the past decades and often correlates with indices of stress in the affected populations. Stress, primarily through hyperactivation of the HPA axis, appears to contribute to the accumulation of fat tissue, and vice versa, obesity itself seems to constitute a chronic stressful state and may cause HPA axis dysfunction. In addition, the description of obesity as a systemic low grade inflammatory condition that contributes to the derangement of the metabolic equilibrium implies that the proinflammatory cytokines which are secreted by the adipocytes hold a potentially important pathogenetic role. In this article we describe the physiology of the stress system response, with emphasis on metabolism, and review the recent data that implicate several neuroendocrine and inflammatory mechanisms mobilized during chronic stress in the development of the metabolic complications that characterize central obesity and the metabolic syndrome.
C1 Univ Athens, Sch Med, Evgenidion Hosp, Endocrinol Metab & Diabet Unit, GR-11528 Athens, Greece.
   Univ Athens, Sch Med, Ag Sophia Childrens Hosp, Dept Pediat 1, GR-11527 Athens, Greece.
   Hellen Natl Diabet Ctr, GR-10675 Athens, Greece.
C3 Athens Medical School; National & Kapodistrian University of Athens;
   National & Kapodistrian University of Athens; Athens Medical School
RP Tsigos, C (corresponding author), 82 Vas Sophias Ave, GR-11528 Athens, Greece.
EM ctsigos@gmail.com
RI Chrousos, George/G-8702-2011
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NR 121
TC 246
Z9 295
U1 1
U2 38
PU BLACKWELL SCIENCE PUBL
PI OXFORD
PA OSNEY MEAD, OXFORD OX2 0EL, ENGLAND
SN 0077-8923
BN 978-1-57331-625-5
J9 ANN NY ACAD SCI
JI Ann.NY Acad.Sci.
PY 2006
VL 1083
BP 77
EP 110
DI 10.1196/annals.1367.008
PG 34
WC Endocrinology & Metabolism; Multidisciplinary Sciences
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Science & Technology - Other Topics
GA BFR90
UT WOS:000244102900008
PM 17148735
DA 2025-06-11
ER

PT J
AU Roque, FR
   Hernanz, R
   Salaices, M
   Briones, AM
AF Roque, Fernanda R.
   Hernanz, Raquel
   Salaices, Mercedes
   Briones, Ana M.
TI Exercise Training and Cardiometabolic Diseases: Focus on the Vascular
   System
SO CURRENT HYPERTENSION REPORTS
LA English
DT Article
DE Exercise training; Diabetes; Obesity; Hypertension; Metabolic syndrome;
   Endothelial dysfunction; Vascular remodeling; Stiffness; Oxidative
   stress; Nitric oxide; Adipokines; Prostanoids
ID ENDOTHELIUM-DEPENDENT VASODILATION; TYPE-2 DIABETES-MELLITUS; AEROBIC
   EXERCISE; BLOOD-PRESSURE; METABOLIC SYNDROME; PHYSICAL-ACTIVITY;
   OXIDATIVE STRESS; WEIGHT-LOSS; CARDIORESPIRATORY FITNESS;
   CARDIOVASCULAR-DISEASE
AB The regular practice of physical activity is a well-recommended strategy for the prevention and treatment of several cardiovascular and metabolic diseases. Physical exercise prevents the progression of vascular diseases and reduces cardiovascular morbidity and mortality. Exercise training also ameliorates vascular changes including endothelial dysfunction and arterial remodeling and stiffness, usually present in type 2 diabetes, obesity, hypertension and metabolic syndrome. Common to these diseases is excessive oxidative stress, which plays an important role in the processes underlying vascular changes. At the vascular level, exercise training improves the redox state and consequently NO availability. Moreover, growing evidence indicates that other mediators such as prostanoids might be involved in the beneficial effects of exercise. The purpose of this review is to update recent findings describing the adaptation response induced by exercise in cardiovascular and metabolic diseases, focusing more specifically on the beneficial effects of exercise in the vasculature and the underlying mechanisms.
C1 [Roque, Fernanda R.; Salaices, Mercedes; Briones, Ana M.] Univ Autonoma Madrid, Fac Med, Dept Farmacol, Inst Invest Hosp Univ La Paz IdiPAZ, E-28029 Madrid, Spain.
   [Hernanz, Raquel] Univ Rey Juan Carlos, Dept Bioquim Fisiol & Genet Mol, Alcorcon, Spain.
   [Salaices, Mercedes; Briones, Ana M.] Univ Autonoma Madrid, Dept Pharmacol, Madrid 28029, Spain.
C3 Hospital Universitario La Paz; Autonomous University of Madrid;
   Universidad Rey Juan Carlos; Autonomous University of Madrid
RP Salaices, M (corresponding author), Univ Autonoma Madrid, Dept Pharmacol, Arzobispo Morcillo 4, Madrid 28029, Spain.
EM mercedes.salaices@uam.es; ana.briones@uam.es
RI HERNANZ, RAQUEL/H-8943-2015; Roque, Fernanda/H-5213-2012
OI Hernanz, Raquel/0000-0002-2624-9387; Briones, Ana/0000-0001-8218-5579;
   Salaices Sanchez, Mercedes/0000-0003-3323-1692
FU Ministerio de Economia y Competitividad [SAF2009-07201, SAF2012-36400];
   Instituto de Salud Carlos III [Red RECAVA, RD06/0014/0011, Retic
   Enfermedades Cardiovasculares RD12/0042/0024]; Fundacion Mutua
   Madrilena; Fundacion Mapfre; Ramon y Cajal Program [RYC-2010-0647];
   CAPES-Brazil scholarship
FX Studies performed by the authors were supported by grants from the
   Ministerio de Economia y Competitividad (SAF2009-07201, SAF2012-36400),
   Instituto de Salud Carlos III (Red RECAVA, RD06/0014/0011, Retic
   Enfermedades Cardiovasculares RD12/0042/0024), Fundacion Mutua Madrilena
   and Fundacion Mapfre. AMB is supported by the Ramon y Cajal Program
   (RYC-2010-06473). FR Roque was the recipient of a CAPES-Brazil
   scholarship.
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NR 129
TC 54
Z9 57
U1 1
U2 29
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1522-6417
EI 1534-3111
J9 CURR HYPERTENS REP
JI Curr. Hypertens. Rep.
PD JUN
PY 2013
VL 15
IS 3
BP 204
EP 214
DI 10.1007/s11906-013-0336-5
PG 11
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 142RL
UT WOS:000318814700012
PM 23519745
DA 2025-06-11
ER

PT J
AU Pak, YK
   Im, S
   Choi, HS
   Lind, L
   Lind, M
   Lee, HK
AF Pak, Youngmi Kim
   Im, Suyeol
   Choi, Hoon Sung
   Lind, Lars
   Lind, Monica
   Lee, Hong Kyu
TI Correlation between environmental pollutant exposure and cardiopulmonary
   health by serum biomarker analysis in the Swedish elderly population
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH
LA English
DT Article
DE POPs; metabolic syndrome; mitochondria; pulmonary; serum biomarker
ID ARYL-HYDROCARBON RECEPTOR; PERSISTENT ORGANIC POLLUTANTS; METABOLIC
   SYNDROME; INSULIN-RESISTANCE; OXIDATIVE STRESS; ORGANOCHLORINE
   PESTICIDES; POLYCHLORINATED-BIPHENYLS; INFLAMMATORY MARKERS; CIRCULATING
   LEVELS; ASSOCIATIONS
AB Persistent organic pollutants (POPs) affect human health through the aryl hydrocarbon receptor (AhR) pathway and are implicated in mitochondrial dysfunction. Using data from the PIVUS study, we investigated the associations of serum AhR ligand (POP)-mediated luciferase activity (AhRL), mitochondrial ATP production inhibiting substances (MIS-ATP), and those affecting reactive oxygen species (MIS-ROS) with several metabolic syndrome (MetS) and cardiopulmonary function parameters. These include insulin resistance (HOMA-IR), inflammation, oxidative stress, and cardiopulmonary variables (FVC, FEV1, LV-EF, CCA distensibility). MIS-ATP showed significant correlations with HOMA-IR and pulmonary functions, indicating its direct impact of MIS-ATP on metabolic and pulmonary health. MIS-ROS correlated with oxidative stress markers and CCA distensibility, suggesting a role in systemic inflammatory responses. This study highlights the intricate relationships between environmental pollutant mixture and cardiopulmonary health in MetS as indicated by biomarkers of POP exposure in the elderly population, suggesting POP exposure may influence MetS onset and progression through mitochondrial dysfunction.
C1 [Pak, Youngmi Kim] Kyung Hee Univ, Med Res Ctr Bioreact React Oxygen Species, Sch Med, Dept Physiol, Seoul, South Korea.
   [Pak, Youngmi Kim; Im, Suyeol; Choi, Hoon Sung] Kyung Hee Univ, Biomed Sci Inst, Sch Med, Seoul, South Korea.
   [Pak, Youngmi Kim; Im, Suyeol] Kyung Hee Univ, Med Res Ctr Bioreact React Oxygen Species, Sch Med, Dept Neurosci, Seoul, South Korea.
   [Choi, Hoon Sung] Chung Ang Univ, Coll Med, Dept Internal Med, Seoul, South Korea.
   [Lind, Lars] Uppsala Univ, Dept Med Sci, Uppsala, Sweden.
   [Lind, Monica] Uppsala Univ, Occupat & Environm Med, Uppsala, Sweden.
   [Lee, Hong Kyu] Seoul Natl Univ, Coll Med, Dept Internal Med, 101 Daehak Ro, Seoul 03080, South Korea.
C3 Kyung Hee University; Kyung Hee University; Kyung Hee University; Chung
   Ang University; Chung Ang University Hospital; Uppsala University;
   Uppsala University; Seoul National University (SNU)
RP Lee, HK (corresponding author), Seoul Natl Univ, Coll Med, Dept Internal Med, 101 Daehak Ro, Seoul 03080, South Korea.
EM hkleemd@snu.ac.kr
RI Kim, Young/C-9839-2015; Lind, Lars/KAM-1968-2024
FU Basic Science Research Program through the National Research Foundation
   of Korea (NRF) - Korean government (MSIT) [2018R1A6A1A03025124,
   2020R1A2C1008699]
FX This research was supported by the Basic Science Research Program (Core
   Research Institute Program [2018R1A6A1A03025124 and 2020R1A2C1008699])
   through the National Research Foundation of Korea (NRF) funded by the
   Korean government (MSIT). The funding source had no role in the
   collection of data or in the decision to submit this manuscript for
   publication.
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NR 60
TC 0
Z9 0
U1 3
U2 4
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0960-3123
EI 1369-1619
J9 INT J ENVIRON HEAL R
JI Int. J. Environ. Health Res.
PD MAY 4
PY 2025
VL 35
IS 5
BP 1156
EP 1169
DI 10.1080/09603123.2024.2382306
EA JUL 2024
PG 14
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA 2DZ5V
UT WOS:001273888600001
PM 39037202
DA 2025-06-11
ER

PT J
AU Rouen, PA
   Krein, SL
   Reame, NE
AF Rouen, Patricia A.
   Krein, Sarah L.
   Reame, Nancy E.
TI Postmenopausal Symptoms in Female Veterans with Type 2 Diabetes: Glucose
   Control and Symptom Severity
SO JOURNAL OF WOMENS HEALTH
LA English
DT Article
ID HUMAN-IMMUNODEFICIENCY-VIRUS; POOR GLYCEMIC CONTROL; WOMENS HEALTH;
   MENOPAUSAL TRANSITION; VASOMOTOR SYMPTOMS; RISK-FACTORS; HOT FLASHES;
   REPRODUCTIVE HORMONES; DEPRESSIVE SYMPTOMS; METABOLIC SYNDROME
AB Background: While type 2 diabetes mellitus (DM) is a common condition of midlife women, few studies have examined its influence on the symptom features of menopause. To explore this relationship, we conducted a study of symptom patterns of diabetic patients using a random sample of female veterans receiving care in the Veterans Affairs Healthcare system. Methods: A cross-sectional comparison was conducted with three groups of postmenopausal respondents (ages 45-60 years) to a mailed national survey who also consented to clinical data access: no diabetes (n=90), diabetes with better glucose control (hemoglobin A1c [HbA1c]7%, n=135) and diabetes with worse glucose control (HbA1c>7%, n=102). Results: Respondents, on average, were obese (body mass index: 33.90.4 kg/m(2)), 11.30 +/- 0.2 years postmenopause, with more than one chronic illness. Despite higher body mass index and increased comorbidities in women with diabetes compared with nondiabetic women, measures of mental health (anxiety, depressed mood, stress) were similar across groups. The pattern of menopause symptoms did not differ by group. Muscle aches/joint pain was the most prevalent symptom (78.6%), followed by vasomotor symptoms (74.4%). Respondents with elevated HbA1c demonstrated higher total menopausal symptom severity scores (DM-HbA1c>7: 15.4 +/- 0.8 vs. DM-HbA1c7%: 12.2 +/- 0.8 vs. No diabetes: 12.3 +/- 0.8; p=0.006) than the other two groups. Conclusions: In postmenopausal female veterans with diabetes, glucose control is associated with the severity of those symptoms commonly attributed to menopause. Joint pain is an important part of the postmenopausal symptom complex in this population.
C1 [Rouen, Patricia A.] Univ Detroit Mercy, McAuley Sch Nursing, Detroit, MI 48221 USA.
   [Krein, Sarah L.] Vet Affairs Healthcare Syst, Ctr Clin Management Res, Ann Arbor, MI USA.
   [Krein, Sarah L.] Univ Michigan, Sch Nursing, Ann Arbor, MI 48109 USA.
   [Krein, Sarah L.] Univ Michigan, Sch Med, Dept Internal Med, Ann Arbor, MI 48109 USA.
   [Reame, Nancy E.] Columbia Univ, Sch Nursing, New York, NY USA.
C3 University of Detroit Mercy; US Department of Veterans Affairs; Veterans
   Health Administration (VHA); VA Ann Arbor Healthcare System; University
   of Michigan System; University of Michigan; University of Michigan
   System; University of Michigan; Columbia University
RP Rouen, PA (corresponding author), Univ Detroit Mercy, McAuley Sch Nursing, 4001 West McNichols Rd, Detroit, MI 48221 USA.
EM rouenpa@udmercy.edu
RI Krein, Sarah/E-2742-2014; reame, nancy/HJI-3454-2023
FU Department of Veterans Affairs, Veterans Health Administration, Health
   Services Research and Development Service Quality Enhancement Research
   Initiative Program [RRP 07-354]; University of Detroit Mercy, Dean's
   Intramural Funding Award; University of Michigan School of Nursing,
   Office of Doctoral and Post-Doctoral studies; Sigma Theta Tau, Lambda
   Zeta chapter
FX This study was supported by grant funds from the Department of Veterans
   Affairs, Veterans Health Administration, Health Services Research and
   Development Service Quality Enhancement Research Initiative Program RRP
   07-354; the University of Detroit Mercy, Dean's Intramural Funding
   Award; the University of Michigan School of Nursing, Office of Doctoral
   and Post-Doctoral studies and Sigma Theta Tau, Lambda Zeta chapter. No
   funder had a role in the design and conduct of the study; collection,
   management, analysis, and interpretation of the data; and preparation,
   review, or approval of the manuscript. The views expressed in this
   article are those of the authors and do not necessarily reflect the
   position or policy of the Department of Veterans Affairs or the United
   States government. This research was conducted while Dr. Rouen was
   completing her doctoral work under the mentorship of Dr. Reame, Rhetaugh
   Graves Dumas Professor of Nursing, School of Nursing at the University
   of Michigan, Ann Arbor, Michigan. Preliminary study results were
   presented at the Annual Meeting of the North American Menopause Society,
   October 1, 2009, San Diego, California. We are most grateful to the
   women who served as research participants. We thank Dr. Joyce Roberts,
   PhD, CNM, retired professor School of Nursing, University of Michigan
   Ann Arbor, Michigan for her valuable support and assistance with project
   development and data interpretation in the original dissertation. We
   also thank Kristine Kulage, Columbia School of Nursing, for her careful
   editing of this manuscript.
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NR 87
TC 9
Z9 10
U1 0
U2 2
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-9996
EI 1931-843X
J9 J WOMENS HEALTH
JI J. Womens Health
PD JUN 1
PY 2015
VL 24
IS 6
BP 496
EP 505
DI 10.1089/jwh.2014.4863
PG 10
WC Public, Environmental & Occupational Health; Medicine, General &
   Internal; Obstetrics & Gynecology; Women's Studies
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; General & Internal
   Medicine; Obstetrics & Gynecology; Women's Studies
GA CU9OP
UT WOS:000363874300006
PM 25938989
OA Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Yang, J
   Suo, HY
   Song, JJ
AF Yang, Jing
   Suo, Huayi
   Song, Jiajia
TI Protective role of mitoquinone against impaired mitochondrial
   homeostasis in metabolic syndrome
SO CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
LA English
DT Review
DE Metabolic syndrome; mitochondria; mitoquinone; oxidative stress
ID TARGETED ANTIOXIDANT MITOQ; ACTIVATED PROTEIN-KINASE; TYPE-2
   DIABETES-MELLITUS; INCREASED OXIDATIVE STRESS; PANCREATIC BETA-CELLS;
   DIET-INDUCED OBESITY; KAPPA-B ACTIVATION; SKELETAL-MUSCLE; DNA-DAMAGE;
   ADIPOSE-TISSUE
AB Mitochondria control various processes in cellular metabolic homeostasis, such as adenosine triphosphate production, generation and clearance of reactive oxygen species, control of intracellular Ca(2+)and apoptosis, and are thus a critical therapeutic target for metabolic syndrome (MetS). The mitochondrial targeted antioxidant mitoquinone (MitoQ) reduces mitochondrial oxidative stress, prevents impaired mitochondrial dynamics, and increases mitochondrial turnover by promoting autophagy (mitophagy) and mitochondrial biogenesis, which ultimately contribute to the attenuation of MetS conditions, including obesity, insulin resistance, hypertension and cardiovascular disease. The regulatory effect of MitoQ on mitochondrial homeostasis is mediated through AMPK and its downstream signaling pathways, including MTOR, SIRT1, Nrf2 and NF-kappa B. However, there are few reviews focusing on the critical role of MitoQ as a therapeutic agent in the treatment of MetS. The purpose of this review is to summarize the mitochondrial role in the pathogenesis of MetS, especially in obesity and type 2 diabetes, and discuss the effect and underlying mechanism of MitoQ on mitochondrial homeostasis in MetS.
C1 [Yang, Jing] Chongqing Technol & Business Univ, Chongqing Engn Res Ctr Proc & Storage Distinct Ag, Chongqing, Peoples R China.
   [Yang, Jing] Chongqing Technol & Business Univ, Grad Sch, Chongqing, Peoples R China.
   [Suo, Huayi; Song, Jiajia] Southwest Univ, Coll Food Sci, Chongqing 400715, Peoples R China.
C3 Chongqing Technology & Business University; Chongqing Technology &
   Business University; Southwest University - China
RP Song, JJ (corresponding author), Southwest Univ, Coll Food Sci, Chongqing 400715, Peoples R China.
EM birget@swu.edu.cn; jiajias@swu.edu.cn
RI Song, Jiajia/HSG-0414-2023; Yang, Jing/HZJ-3722-2023
OI Song, Jiajia/0000-0001-6753-518X; Yang, Jing/0000-0002-1352-225X
FU Science and Technology Research Program of Chongqing Municipal Education
   Commission [KJQN201900822]; Chongqing Engineering Research Center for
   Processing & Storage of Distinct Agricultural Products [KFJJ2019090];
   Fundamental Research Funds for the Central Universities [SWU019026];
   Chongqing Technology and Business University [1956024]
FX This study was financial sponsored by Science and Technology Research
   Program of Chongqing Municipal Education Commission (Grant No.
   KJQN201900822), Chongqing Engineering Research Center for Processing &
   Storage of Distinct Agricultural Products (Grant No. KFJJ2019090),
   Fundamental Research Funds for the Central Universities (Grant No.
   SWU019026), and Chongqing Technology and Business University (Grant No.
   1956024).
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NR 245
TC 50
Z9 52
U1 0
U2 64
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1040-8398
EI 1549-7852
J9 CRIT REV FOOD SCI
JI Crit. Rev. Food Sci. Nutr.
PD DEC 16
PY 2021
VL 61
IS 22
BP 3857
EP 3875
DI 10.1080/10408398.2020.1809344
EA AUG 2020
PG 19
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA XN7ET
UT WOS:000560861800001
PM 32815398
DA 2025-06-11
ER

PT J
AU Chen, Y
   Cai, YF
   Wang, K
   Wang, YS
AF Chen, Ying
   Cai, Yunfei
   Wang, Ke
   Wang, Yousheng
TI Bioactive Compounds in Sea Buckthorn and their Efficacy in Preventing
   and Treating Metabolic Syndrome
SO FOODS
LA English
DT Review
DE sea buckthorn; metabolic syndrome; bioactive compounds
ID HIPPOPHAE-RHAMNOIDES-L.; CORONARY-HEART-DISEASE; ANTIOXIDANT ACTIVITY;
   SEED OIL; OXIDATIVE STRESS; PHENOLIC-ACIDS; RISK-FACTORS; VITAMIN-E;
   BERRIES; FLAVONOIDS
AB Sea buckthorn (Hippophae rhamnoides L. or Elaeagnus rhamnoides L.) is a plant that has long been used as a Chinese herbal medicine. This species is known to contain numerous bioactive components, including polyphenols, fatty acids, vitamins, and phytosterols, which may be responsible for its medicinal value. In experiments both in vitro and in vivo (ranging from cell lines to animal models and human patients), sea buckthorn has shown positive effects on symptoms of metabolic syndrome; evidence suggests that sea buckthorn treatment can decrease blood lipid content, blood pressure, and blood sugar levels, and regulate key metabolites. This article reviews the main bioactive compounds present in sea buckthorn and discusses their efficacy in treating metabolic syndrome. Specifically, we highlight bioactive compounds isolated from distinct sea buckthorn tissues; their effects on abdominal obesity, hypertension, hyperglycemia, and dyslipidemia; and their potential mechanisms of action in clinical applications. This review provides key insight into the benefits of sea buckthorn, promoting future research of this species and expansion of sea buckthorn-based therapies for metabolic syndrome.
C1 [Chen, Ying; Cai, Yunfei; Wang, Ke; Wang, Yousheng] Beijing Technol & Business Univ, Key Lab Geriatr Nutr & Hlth, Minist Educ, Beijing 100048, Peoples R China.
   [Wang, Yousheng] Shandong Keepfit Biotech Co Ltd, Rizhao Huawei Inst Comprehens Hlth Ind, Rizhao 276800, Peoples R China.
C3 Ministry of Education - China; Beijing Technology & Business University
RP Wang, YS (corresponding author), Beijing Technol & Business Univ, Key Lab Geriatr Nutr & Hlth, Minist Educ, Beijing 100048, Peoples R China.; Wang, YS (corresponding author), Shandong Keepfit Biotech Co Ltd, Rizhao Huawei Inst Comprehens Hlth Ind, Rizhao 276800, Peoples R China.
EM chenying@btbu.edu.cn; wangys@btbu.edu.cn
RI CAI, YUNFEI/LDU-1678-2024
FU National Natural Science Foundation of China [31972127, 31471626];
   Natural Science Foundation of Rizhao [202117]; Academy of Finland (AKA)
   [202117] Funding Source: Academy of Finland (AKA)
FX This work was funded by the National Natural Science Foundation of China
   [grant number 31972127; 31471626] and the Natural Science Foundation of
   Rizhao [grant number 202117].
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NR 100
TC 17
Z9 18
U1 29
U2 128
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2304-8158
J9 FOODS
JI Foods
PD MAY 13
PY 2023
VL 12
IS 10
AR 1985
DI 10.3390/foods12101985
PG 25
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA H5TJ2
UT WOS:000996582900001
PM 37238803
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Su, ZQ
   Li, HX
   Ye, ZT
   Zhu, Y
   Feng, B
   Tang, LP
   Zheng, GJ
AF Su, Zuqing
   Li, Hongxia
   Ye, Zeting
   Zhu, Ying
   Feng, Bing
   Tang, Lipeng
   Zheng, Guangjuan
TI Qidan Tiaozhi capsule attenuates metabolic syndrome via activating
   AMPK/PINK1-Parkin-mediated mitophagy
SO JOURNAL OF ETHNOPHARMACOLOGY
LA English
DT Article
DE Network pharmacology; Molecular docking; Metabolic syndrome; Insulin
   resistance; Qidan Tiaozhi capsule; AMPK; PINK1-Parkin-mediated mitophagy
ID GLYCATION END-PRODUCTS; INSULIN-RESISTANCE; NADPH OXIDASE; CYTOKINES
AB Ethnopharmacological relevance: Qidan Tiaozhi capsule (QD), a traditional Chinese medicine, has been used to treat metabolic syndrome for over a decade. However, the mechanism of QD in the treatment of metabolic syndrome is still unknown.Aim of the study: Growing studies demonstrate that impaired mitophagy is one of the important causes of metabolic syndrome. Thus, this research aims to investigate the mechanism of mitophagy in the QD treatment of metabolic syndrome.Materials and methods: Network pharmacology and molecular docking were used to probe the mechanism of QD treatment of metabolic syndrome. In an oleic acid-induced cell model, glucose consumption and uptake capacity, triglyceride (TG), total cholesterol (TC), malonaldehyde (MDA), superoxide dismutase (SOD) and ROS levels, and mitochondrial membrane potential (MMP) were examined. mRFP-GFP-LC3 adenovirus and GFP-LC3 lentivirus were used to examine the effect of QD on mitophagy. The IRS2-PI3K and AMPK/PINK1-Parkin signal pathways were also determined. What's more, the PINK1 gene was silenced to verify the above findings. In a high-fat dietfed mouse model, body weight, organ indexes, OGTT, ITT, HOMA-IR, insulin sensitivity, serum MDA, SOD, TC, TG, LDL-C and HDL-C, hepatic TC, TG, LDL-C and HDL-C levels, hepatic steatosis, and IRS2-PI3K and AMPK/ PINK1-Parkin signal pathways were investigated. Results: Results from network pharmacology and molecular docking suggested that QD might suppress oxidative stress to improve metabolic syndrome. In an oleic acid-induced cell model, compared with the model group, enhanced glucose consumption and uptake ability, inhibited intracellular lipid accumulation, TC, TG, MDA and ROS levels, and increased SOD level and MMP were found in QD groups. And mitophagy levels, IRS2-PI3K and AMPK/PINK1-Parkin signal pathways were promoted. Interestingly, PINK1 silencing reversed the therapeutic action of QD on oleic acid-induced cells. In high-fat diet-fed mice, inhibited body weight, abdominal fat indexes, liver indexes, HOMA-IR, serum and hepatic TC, TG and LDL-C, serum MDA and hepatic steatosis, and increased insulin sensitivity, serum and hepatic HDL-C, serum SOD, and activated IRS2-PI3K and AMPK/PINK1-Parkin signal pathways were found in QD groups. Conclusion: QD activates AMPK/PINK1-Parkin-mediated mitophagy to suppress oxidative stress to treat metabolic syndrome.
C1 [Su, Zuqing; Li, Hongxia; Ye, Zeting; Zhu, Ying; Feng, Bing; Tang, Lipeng; Zheng, Guangjuan] Guangzhou Univ Chinese Med, State Key Lab Dampness Syndrome Chinese Med, Clin Coll 2, Guangzhou, Peoples R China.
   [Su, Zuqing; Li, Hongxia; Ye, Zeting; Zhu, Ying; Feng, Bing; Tang, Lipeng; Zheng, Guangjuan] Guangzhou Univ Chinese Med, Dept Pharmacol Tradit Chinese Med, Clin Coll 2, Guangzhou, Peoples R China.
   [Su, Zuqing; Li, Hongxia; Ye, Zeting; Zhu, Ying; Feng, Bing; Tang, Lipeng; Zheng, Guangjuan] Guangzhou Univ Chinese Med, Guangdong Hong Kong Macau Joint Lab Chinese Med &, Clin Coll 2, Hong Kong, Guangdong, Peoples R China.
C3 Guangzhou University of Chinese Medicine; Guangzhou University of
   Chinese Medicine; Guangzhou University of Chinese Medicine
RP Zheng, GJ (corresponding author), Guangzhou Univ Chinese Med, State Key Lab Dampness Syndrome Chinese Med, Clin Coll 2, Guangzhou, Peoples R China.; Zheng, GJ (corresponding author), Guangzhou Univ Chinese Med, Dept Pharmacol Tradit Chinese Med, Clin Coll 2, Guangzhou, Peoples R China.; Zheng, GJ (corresponding author), Guangzhou Univ Chinese Med, Guangdong Hong Kong Macau Joint Lab Chinese Med &, Clin Coll 2, Hong Kong, Guangdong, Peoples R China.
EM zhengguangjuan@gzucm.edu.cn
RI Feng, Bing/HJP-0540-2023; Zheng, Guangjuan/ABB-6496-2020; Tang,
   Lipeng/ABB-6481-2020
FU Research Fund for Zhaoyang Talents of Guangdong Provincial Hospital of
   Chinese Medicine [ZY2022KY12]; Specific Fund of State Key Laboratory of
   Dampness Syndrome of Chinese Medicine [SZ2021ZZ20]; Guangdong Provincial
   Science and Technology Innovation Strategy Special Fund (Guangdong-Hong
   Kong-Macau Joint Lab) [2020B1212030006]; Chinese Medicine Scientific
   Research and Technology Research Projects of Guangdong Provincial
   Hospital of Chinese Medicine [YN2018QJ04, YN2019QJ10]; Guangdong
   Provincial Key Laboratory of Chinese Medicine for Prevention and
   Treatment of Refractory Chronic Diseases [2018B030322012]; Medical
   Scientific Research Foundation of Guangdong Province of China [B2020084]
FX This work was supported by grants from the Research Fund for Zhaoyang
   Talents of Guangdong Provincial Hospital of Chinese Medicine (No.
   ZY2022KY12) , the Specific Fund of State Key Laboratory of Dampness
   Syndrome of Chinese Medicine under Grant (No. SZ2021ZZ20) , the 2020
   Guangdong Provincial Science and Technology Innovation Strategy Special
   Fund (Guangdong-Hong Kong-Macau Joint Lab) (No. 2020B1212030006) , the
   Chinese Medicine Scientific Research and Technology Research Projects of
   Guangdong Provincial Hospital of Chinese Medicine (No. YN2018QJ04 and
   YN2019QJ10) , the Guangdong Provincial Key Laboratory of Chinese
   Medicine for Prevention and Treatment of Refractory Chronic Diseases
   (No. 2018B030322012) , and the Medical Scientific Research Foundation of
   Guangdong Province of China (No. B2020084) .
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U2 26
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0378-8741
EI 1872-7573
J9 J ETHNOPHARMACOL
JI J. Ethnopharmacol.
PD MAY 10
PY 2023
VL 307
AR 116091
DI 10.1016/j.jep.2022.116091
EA FEB 2023
PG 16
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA 8X5GK
UT WOS:000932040800001
PM 36592823
DA 2025-06-11
ER

PT J
AU Moreira, EG
   Boll, KM
   Correia, DG
   Soares, JF
   Rigobello, C
   Maes, M
AF Moreira, Estefania Gastaldello
   Boll, Karine Maria
   Correia, Dalmo Guilherme
   Soares, Janaina Favaro
   Rigobello, Camila
   Maes, Michael
TI Why Should Psychiatrists and Neuroscientists Worry about Paraoxonase 1?
SO CURRENT NEUROPHARMACOLOGY
LA English
DT Review
DE PON1; major depressive disorder; bipolar disorder; schizophrenia;
   inflammation; oxidative stress; PON1 modulators
ID HIGH-DENSITY-LIPOPROTEIN; PON1 Q192R POLYMORPHISM; PROTEIN-KINASE-C;
   SERUM PARAOXONASE; OXIDATIVE STRESS; CARDIOVASCULAR-DISEASE; METABOLIC
   SYNDROME; GENE-EXPRESSION; POSTPRANDIAL PARAOXONASE-1;
   SCHIZOPHRENIC-PATIENTS
AB Background: Nitro-oxidative stress (NOS) has been implicated in the pathophysiology of psychiatric disorders. The activity of the polymorphic antioxidant enzyme paraoxonase 1 (PON1) is altered in diseases where NOS is involved. PON1 activity may be estimated using different substrates some of which are influenced by PON1 polymorphisms.
   Objectives: 1) to review the association between PON1 activities and psychiatric diseases using a standardized PON1 substrate terminology in order to offer a state-of-the-art review; and 2) to review the efficacy of different strategies (nutrition, drugs, lifestyle) to enhance PON1 activities.
   Methods: The PubMed database was searched using the terms paraoxonase 1 and psychiatric diseases. Moreover, the database was also searched for clinical trials investigating strategies to enhance PON1 activity.
   Results: The studies support decreased PON1 activity as determined using phenylacetate (i.e., arylesterase or AREase) as a substrate, in depression, bipolar disorder, generalized anxiety disorder (GAD) and schizophrenia, especially in antipsychotic-free patients. PON1 activity as determined with paraoxon (i.e., POase activity) yields more controversial results, which can be explained by the lack of adjustment for the Q192R polymorphism. The few clinical trials investigating the influence of nutritional, lifestyle and drugs on PON1 activities in the general population suggest that some polyphenols, oleic acid, Mediterranean diet, no smoking, being physically active and statins may be effective strategies that increase PON1 activity.
   Conclusion: Lowered PON1 activities appear to be a key component in the ongoing NOS processes that accompany affective disorders, GAD and schizophrenia. Treatments increasing attenuated PON1 activity could possibly be new drug targets for treating these disorders.
C1 [Moreira, Estefania Gastaldello; Boll, Karine Maria; Rigobello, Camila] State Univ Londrina UEL, Grad Program Hlth Sci, Londrina, PR, Brazil.
   [Correia, Dalmo Guilherme; Soares, Janaina Favaro] Univ Estadual Londrina, Med Sch, Londrina, PR, Brazil.
   [Moreira, Estefania Gastaldello] Univ Estadual Londrina, Dept Physiol Sci, Londrina, PR, Brazil.
   [Maes, Michael] Chulalongkorn Univ, Fac Med, Dept Psychiat, Bangkok, Thailand.
   [Maes, Michael] Chulalongkorn Univ, Med Univ Plovdiv, Dept Psychiat, Plovdiv, Bulgaria.
   [Maes, Michael] Deakin Univ, Plovdiv, Bulgaria.
   [Maes, Michael] Deakin Univ, Impact Strateg Ctr, Geelong, Vic, Australia.
C3 Universidade Estadual de Londrina; Universidade Estadual de Londrina;
   Universidade Estadual de Londrina; Chulalongkorn University;
   Chulalongkorn University; Medical University Plovdiv; Deakin University
RP Moreira, EG (corresponding author), Ctr Ciencias Biol, Dept Ciencias Fisiol, Lab 6, BR-86057970 Londrina, PR, Brazil.
EM egmoreira@uel.br
RI Moreira, Estefania/AAC-5959-2019; Maes, Michael/B-8546-2011
OI Moreira, Estefania/0000-0001-8362-9557; Correia, Dalmo
   Guilherme/0000-0003-0086-6958
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NR 154
TC 35
Z9 36
U1 0
U2 13
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1570-159X
EI 1875-6190
J9 CURR NEUROPHARMACOL
JI Curr. Neuropharmacol.
PY 2019
VL 17
IS 11
BP 1004
EP 1020
DI 10.2174/1570159X17666181227164947
PG 17
WC Neurosciences; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Pharmacology & Pharmacy
GA JD1NO
UT WOS:000489741600001
PM 30592255
OA Green Published
DA 2025-06-11
ER

PT J
AU Bostan, C
   Yildiz, A
   Ozkan, AA
   Uzunhasan, I
   Kaya, A
   Yigit, Z
AF Bostan, Cem
   Yildiz, Ahmet
   Ozkan, Alev Arat
   Uzunhasan, Isil
   Kaya, Aysem
   Yigit, Zerrin
TI Beneficial Effects of Rosuvastatin Treatment in Patients With Metabolic
   Syndrome
SO ANGIOLOGY
LA English
DT Article
DE metabolic syndrome; rosuvastatin; cholesterol subgroups; oxidative
   stress
ID DENSITY-LIPOPROTEIN PARTICLES; CHOLESTEROL EDUCATION-PROGRAM;
   CORONARY-ARTERY-DISEASE; OXIDATIVE STRESS; CLINICAL-SIGNIFICANCE; LDL
   SUBCLASSES; EUROPEAN PANEL; RISK-FACTORS; SIZE; INFLAMMATION
AB We determined the effect of 6-month rosuvastatin treatment on blood lipids, oxidative parameters, apolipoproteins, high-sensitivity C-reactive protein, lipoprotein(a), homocysteine, and glycated hemoglobin (HbA(1c)) in patients with metabolic syndrome (MetS). Healthy individuals (men aged >40 years and postmenopausal women) with a body mass index 30 (n = 100) who fulfilled the National Cholesterol Education Program Adult Treatment Panel III diagnostic criteria for MetS were included. Total cholesterol and low-density lipoprotein cholesterol (LDL-C) levels decreased (P < .0001). The change in LDL 1 to 3 subgroups was significant (P = .0007, P < .0001, and P = .006, respectively). Changes in LDL 4 to 7 subgroups were not significant. There was a beneficial effect on oxidized LDL, fibrinogen, homocysteine, and HbA(1c). Rosuvastatin significantly increased high-density lipoprotein levels (P = .0003). The oxidant/antioxidant status and subclinical inflammatory state were also beneficially changed. Rosuvastatin had a significant beneficial effect on atherogenic dyslipidemia as well as on oxidative stress and inflammatory biomarkers in patients with MetS.
C1 [Bostan, Cem; Yildiz, Ahmet; Ozkan, Alev Arat; Uzunhasan, Isil; Yigit, Zerrin] Istanbul Univ, Dept Cardiol, Inst Cardiol, TR-34350 Istanbul, Turkey.
   [Kaya, Aysem] Istanbul Univ, Dept Biochem, Inst Cardiol, TR-34350 Istanbul, Turkey.
C3 Istanbul University; Istanbul University
RP Bostan, C (corresponding author), Istanbul Univ, Dept Cardiol, Inst Cardiol, TR-34350 Istanbul, Turkey.
EM bostancem@yahoo.com
RI Uzunhasan, Isil/D-8376-2019; Bostan, Cem/AAC-5345-2021; Kaya,
   Aysem/N-4974-2015; Yıldız, Ahmet/AAH-6946-2019; Arat-Ozkan,
   Alev/A-8073-2016
OI Arat-Ozkan, Alev/0000-0001-8064-7231; Yildiz, Ahmet/0000-0001-9477-0740;
   Kaya, Aysem/0000-0003-3137-821X
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NR 45
TC 15
Z9 16
U1 0
U2 12
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0003-3197
EI 1940-1574
J9 ANGIOLOGY
JI Angiology
PD FEB
PY 2015
VL 66
IS 2
BP 122
EP 127
DI 10.1177/0003319714522107
PG 6
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA AZ1DL
UT WOS:000347980400005
PM 24554427
DA 2025-06-11
ER

PT J
AU Legeay, S
   Rodier, M
   Fillon, L
   Faure, S
   Clere, N
AF Legeay, Samuel
   Rodier, Marion
   Fillon, Laetitia
   Faure, Sebastien
   Clere, Nicolas
TI Epigallocatechin Gallate: A Review of Its Beneficial Properties to
   Prevent Metabolic Syndrome
SO NUTRIENTS
LA English
DT Review
DE metabolic syndrome; green tea; epigallocatechin gallate; EGCG;
   endothelial dysfunction; cardiovascular diseases
ID GREEN TEA CATECHINS; REDUCES BLOOD-PRESSURE; ENDOTHELIAL-CELLS;
   OXIDATIVE STRESS; SIGNALING PATHWAYS; INSULIN-RESISTANCE; NITRIC-OXIDE;
   DIABETIC-NEPHROPATHY; DNA METHYLATION; ANGIOTENSIN-II
AB Obesity and being overweight are linked with a cluster of metabolic and vascular disorders that have been termed the metabolic syndrome. This syndrome promotes the incidence of cardiovascular diseases that are an important public health problem because they represent a major cause of death worldwide. Whereas there is not a universally-accepted set of diagnostic criteria, most expert groups agree that this syndrome is defined by an endothelial dysfunction, an impaired insulin sensitivity and hyperglycemia, dyslipidemia, abdominal obesity and hypertension. Epidemiological studies suggest that the beneficial cardiovascular health effects of diets rich in green tea are, in part, mediated by their flavonoid content, with particular benefits provided by members of this family such as epigallocatechin gallate (EGCG). Although their bioavailability is discussed, various studies suggest that EGCG modulates cellular and molecular mechanisms of various symptoms leading to metabolic syndrome. Therefore, according to in vitro and in vivo model data, this review attempts to increase our understanding about the beneficial properties of EGCG to prevent metabolic syndrome.
C1 [Legeay, Samuel; Rodier, Marion; Faure, Sebastien; Clere, Nicolas] LUNAM Univ, INSERM, Stress Oxydant & Pathol Metabol, U1063, F-49045 Angers, France.
   [Legeay, Samuel; Rodier, Marion; Fillon, Laetitia; Faure, Sebastien; Clere, Nicolas] LUNAM Univ, Dept Pharm, Lab Pharmacol, UFR Sci Pharmaceut & Ingn Sante, F-49045 Angers, France.
C3 Institut National de la Sante et de la Recherche Medicale (Inserm);
   Universite d'Angers
RP Clere, N (corresponding author), LUNAM Univ, INSERM, Stress Oxydant & Pathol Metabol, U1063, F-49045 Angers, France.
EM samuel.legeay@etud.univ-angers.fr; marion.rodier@univ-angers.fr;
   laetitia.fillon@gmail.com; sebastien.faure@univ-angers.fr;
   nicolas.clere@univ-angers.fr
RI Clere, Nicolas/K-4414-2015; LEGEAY, Samuel/ABA-4681-2021
OI Legeay, Samuel/0000-0001-5393-995X; Faure,
   Sebastien/0000-0001-7524-8295; Clere, Nicolas/0000-0002-6008-597X
FU School of pharmacy (Angers)
FX Authors thank the School of pharmacy (Angers) for its grant to realize
   this work.
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NR 151
TC 250
Z9 266
U1 4
U2 129
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JUL
PY 2015
VL 7
IS 7
BP 5443
EP 5468
DI 10.3390/nu7075230
PG 26
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA CO7OQ
UT WOS:000359349800021
PM 26198245
OA gold, Green Submitted, Green Published
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Correia, MLG
   Rahmouni, K
AF Correia, Marcelo L. G.
   Rahmouni, Kamal
TI Role of leptin in the cardiovascular and endocrine complications of
   metabolic syndrome
SO DIABETES OBESITY & METABOLISM
LA English
DT Review
DE diabetes; hypertension; leptin; lipotoxicity; metabolic syndrome;
   obesity; selective leptin resistance
ID OBESITY-RELATED HYPERTENSION; OXIDATIVE STRESS; ARTERIAL THROMBOSIS;
   ENDOTHELIAL-CELLS; BLOOD-PRESSURE; NERVOUS-SYSTEM; PLASMA LEPTIN; SERUM
   LEPTIN; NITRIC-OXIDE; RISK-FACTOR
AB Aim: To review the potential role of leptin, hyperleptinaemia and leptin resistance in the cardiovascular and endocrine complications of metabolic syndrome.
   Methods: Review of literature listed in Medline.
   Results: Hyperleptinaemia is common in obesity and reflects increased adiposity and leptin resistance. Nevertheless, leptin resistance may not be complete as several actions of leptin, such as cardiovascular sympatho-activation, might be preserved in obese subjects known to be resistant to the metabolic effects of leptin (i.e. selective leptin resistance). Notably, the renal and sympathetic actions of leptin may play an important role in the pathogenesis of hypertension related to obesity and metabolic syndrome. Furthermore, the lipotoxic effect of leptin resistance may cause insulin resistance and beta cell dysfunction, increasing the risk of type 2 diabetes. Leptin has also been shown to possess proliferative, pro-inflammatory, pro-thrombotic, and pro-oxidative actions.
   Conclusion: Hyperleptinaemia and leptin resistance may contribute to hypertension, impaired glucose metabolism, and pro-atherogenic state in obesity and metabolic syndrome.
C1 Univ Iowa, UIHC,Carver Coll Med, Gen Clin Res Ctr,Dept Internal Med, Hypertens Genet Specialized Ctr Res, Iowa City, IA 52242 USA.
C3 University of Iowa
RP Correia, MLG (corresponding author), Univ Iowa, UIHC,Carver Coll Med, Gen Clin Res Ctr,Dept Internal Med, Hypertens Genet Specialized Ctr Res, 157 MRF,200 Hawkins Dr, Iowa City, IA 52242 USA.
EM marcelo-correia@uiowa.edu
RI Rahmouni, Kamal/Y-1788-2019
OI Rahmouni, Kamal/0000-0001-5136-6748; Correia,
   Marcelo/0000-0002-3470-6234
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NR 56
TC 93
Z9 107
U1 2
U2 16
PU BLACKWELL PUBLISHING
PI OXFORD
PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND
SN 1462-8902
J9 DIABETES OBES METAB
JI Diabetes Obes. Metab.
PD NOV
PY 2006
VL 8
IS 6
BP 603
EP 610
DI 10.1111/j.1463-1326.2005.00562.x
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 091MT
UT WOS:000241033700002
PM 17026484
OA Bronze
DA 2025-06-11
ER

PT J
AU Eren, OC
   Ortiz, A
   Afsar, B
   Covic, A
   Kuwabara, M
   Lanaspa, MA
   Johnson, RJ
   Kanbay, M
AF Eren, Ozgur C.
   Ortiz, Alberto
   Afsar, Baris
   Covic, Adrian
   Kuwabara, Masanari
   Lanaspa, Miguel A.
   Johnson, Richard J.
   Kanbay, Mehmet
TI Multilayered Interplay Between Fructose and Salt in Development of
   Hypertension: What Has Been Revealed So Far
SO HYPERTENSION
LA English
DT Review
ID ALPHA-LIPOIC ACID; ELEVATES BLOOD-PRESSURE; INSULIN-RESISTANCE; PROXIMAL
   TUBULE; METABOLIC SYNDROME; URIC-ACID; OXIDATIVE STRESS; ANGIOTENSIN-II;
   DIETARY SALT; RENAL SODIUM
C1 [Kanbay, Mehmet] Koc Univ, Sch Med, Div Nephrol, Istanbul, Turkey.
   [Eren, Ozgur C.; Kanbay, Mehmet] Koc Univ, Sch Med, Dept Med, Istanbul, Turkey.
   [Ortiz, Alberto] Univ Autonoma Madrid, IIS Fdn Jimenez Diaz, Sch Med, Dialysis Unit, Madrid, Spain.
   [Afsar, Baris] Suleyman Demirel Univ, Sch Med, Dept Med, Div Nephrol, Isparta, Turkey.
   [Covic, Adrian] CI PARHON Univ Hosp, Nephrol Clin, Dialysis & Renal Transplant Ctr, Iasi, Romania.
   [Covic, Adrian] Grigore T Popa Univ Med, Iasi, Romania.
   [Kuwabara, Masanari] Toranomon Gen Hosp, Dept Cardiol, Tokyo, Japan.
   [Lanaspa, Miguel A.; Johnson, Richard J.] Univ Colorado Denver, Sch Med, Div Renal Dis & Hypertens, Aurora, CO USA.
C3 Koc University; Koc University; Autonomous University of Madrid;
   Fundacion Jimenez Diaz; Suleyman Demirel University; National Institute
   of Endocrinology C.I. Parhon; Grigore T Popa University of Medicine &
   Pharmacy; Toranomon Hospital; University of Colorado System; University
   of Colorado Anschutz Medical Campus; Children's Hospital Colorado
RP Kanbay, M (corresponding author), Koc Univ, Div Nephrol, Dept Med, Sch Med, TR-34450 Istanbul, Turkey.
EM mkanbay@ku.edu.tr
RI Covic, Adrian/G-5017-2016; Lanaspa, Miguel/AAO-4971-2020; ortiz,
   alberto/Y-7582-2018; 1, 1/IAO-4606-2023; Eren, Ozgur Can/AEB-7376-2022;
   Kuwabara, Masanari/O-9844-2017
OI Kuwabara, Masanari/0000-0002-6601-4347; Eren, Ozgur
   Can/0000-0001-9889-2702
FU Institute of Health Carlos III (ISCIII); FEDER funds [PI16/02057];
   Sociedad Espanola de Nefrologia; ISCIII-RETIC REDinREN [RD016/009];
   Comunidad de Madrid [CIFRA2 B2017/BMD-3686]; Republic of Turkey,
   Ministry of Development; National Institutes of Health, National
   Institute of Diabetes and Digestive and Kidney Diseases grant
   [1RO1DK109408]
FX A. Ortiz was supported by Institute of Health Carlos III (ISCIII) and
   FEDER funds, PI16/02057, Sociedad Espanola de Nefrologia, ISCIII-RETIC
   REDinREN RD016/009, Comunidad de Madrid CIFRA2 B2017/BMD-3686. M. Kanbay
   gratefully acknowledges use of the services and facilities of the KoC
   University Research Center for Translational Medicine (KUTTAM), funded
   by the Republic of Turkey, Ministry of Development. M.A. Lanaspa and
   R.J. Johnson were supported by National Institutes of Health, National
   Institute of Diabetes and Digestive and Kidney Diseases grant
   1RO1DK109408. The content is solely the responsibility of the authors
   and does not necessarily represent the official views of the Ministry of
   Development.
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NR 119
TC 21
Z9 21
U1 0
U2 20
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0194-911X
EI 1524-4563
J9 HYPERTENSION
JI Hypertension
PD FEB
PY 2019
VL 73
IS 2
BP 265
EP 272
DI 10.1161/HYPERTENSIONAHA.118.12150
PG 8
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA HO9XK
UT WOS:000461318900005
PM 30595116
OA Green Accepted, Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Parker, VL
   Liechty, JM
   Cantoni, NP
AF Parker, Vanessa L.
   Liechty, Janet M.
   Cantoni, Nicole P.
TI Associations Between Trauma and Health Behaviors and Outcomes Among
   Sexual Minoritized Adults: A Scoping Review
SO TRAUMA VIOLENCE & ABUSE
LA English
DT Review
DE scoping review; trauma; sexual minority adults; health; health behaviors
ID ADVERSE CHILDHOOD EXPERIENCES; CARDIOMETABOLIC RISK; MENTAL-HEALTH;
   STRESS; GAY; ORIENTATION; VICTIMIZATION; NEUROBIOLOGY; RESILIENCE;
   INDICATORS
AB Sexual minoritized (SM) adults experience health disparities and report higher rates of trauma history compared to heterosexual adults. This scoping review synthesizes the extant literature that investigates associations between trauma and physical health among SM adults. It also describes research instruments utilized to assess trauma in relation to health outcomes among SM adults. We searched CINAHL, LGBT+ Life, PsycINFO, and PubMed to identify studies meeting inclusion criteria: peer-reviewed, English, assessed trauma as an independent variable, and assessed health behaviors or outcomes among SM adults. From 587 nonduplicate articles, 69 full texts were reviewed; 18 met criteria and were included in this review. To enhance rigor, we utilized the Preferred Reporting Items for Systematic Reviews and Meta-Analysis Scoping Reviews checklist. Most (n = 12) of the included studies were cross-sectional. Trauma was assessed 16 different ways, including 9 validated measures, in relation to 5 health behaviors and 17 health conditions. Trauma was operationalized by history of childhood sexual abuse, adverse childhood experiences, lifetime rape, current symptoms of post-traumatic stress disorder, and lifetime victimization among SM adults. All but one study found associations between trauma and one or more unfavorable health behaviors or outcomes. Studies used widely heterogeneous instruments to assess trauma, health, and SM identity. Greater specification and standardization of measurement is needed, along with contextualized assessments of trauma and its impact on health such as sexual minority stress-related victimization and resilience, and post-traumatic growth and recovery processes.
C1 [Parker, Vanessa L.] Indiana Univ, Bloomington, IN USA.
   [Liechty, Janet M.] Univ Illinois, Champaign, IL USA.
   [Liechty, Janet M.] Univ Illinois, Carle Illinois Coll Med, Champaign, IL USA.
   [Cantoni, Nicole P.] Stockton Univ, Galloway, NJ USA.
   [Parker, Vanessa L.] Indiana Univ, Sch Social Work, 2631 E Discovery Pkwy, Bloomington, IN 47408 USA.
C3 Indiana University System; Indiana University Bloomington; University of
   Illinois System; University of Illinois Urbana-Champaign; University of
   Illinois System; University of Illinois Urbana-Champaign; Stockton
   University; Indiana University System; Indiana University Bloomington
RP Parker, VL (corresponding author), Indiana Univ, Sch Social Work, 2631 E Discovery Pkwy, Bloomington, IN 47408 USA.
EM vlparker@iu.edu
RI Cantoni, Nicole/NIU-1093-2025
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NR 46
TC 0
Z9 0
U1 3
U2 9
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1524-8380
EI 1552-8324
J9 TRAUMA VIOLENCE ABUS
JI Trauma Violence Abus.
PD OCT
PY 2024
VL 25
IS 4
BP 2972
EP 2985
DI 10.1177/15248380241233270
EA FEB 2024
PG 14
WC Criminology & Penology; Family Studies; Social Work
WE Social Science Citation Index (SSCI)
SC Criminology & Penology; Family Studies; Social Work
GA G6R8C
UT WOS:001175105200001
PM 38415318
DA 2025-06-11
ER

PT J
AU Himel, AR
   Cabral, SA
   Shaffery, JP
   Grayson, BE
AF Himel, Alexandra R.
   Cabral, Sharon A.
   Shaffery, James P.
   Grayson, Bernadette E.
TI Anxiety behavior and hypothalamic-pituitary-adrenal axis altered in a
   female rat model of vertical sleeve gastrectomy
SO PLOS ONE
LA English
DT Article
ID GASTRIC BYPASS-SURGERY; NATIONAL EPIDEMIOLOGIC SURVEY; BODY-MASS INDEX;
   QUALITY-OF-LIFE; BARIATRIC SURGERY; PSYCHIATRIC-DISORDERS; SELF-HARM;
   METABOLIC SYNDROME; MESSENGER-RNA; WEIGHT-LOSS
AB Surgical weight loss results in a host of metabolic changes that culminate in net positive health benefit to the patients. However, the psychological impact of these surgeries has not been fully studied. On one hand, surgical weight loss has been reported to improve standard quality of life and resolution of symptoms of depression. But on the other hand, reports of self-harm and increased ER visits for self-harm suggest other psychological difficulties. Inability to handle anxiety following surgical weight loss has alarming potential ramifications for these gastric surgery patients. In the present study, we used models of diet-induced obesity and vertical sleeve gastrectomy (VSG) to ask whether anxiety behavior and hypothalamic-pituitary-adrenal (HPA) axis gene changes were affected by surgical weight loss under two diet regimens: i.e. low-fat diet (LFD) and high-fat diet (HFD). We show reduced exploratory behavior in the open field test but increased time in the open arms of the elevated plus maze. Furthermore, we show increased plasma levels of corticosterone in female VSG recipients in the estrus phase and increased levels of hypothalamic arginine-vasopressin (avp), pro-opiomelanocortin (pomc), and tyrosine hydroxylase (th). We report reduced dopamine receptor D1 (drd1) gene in prefrontal cortex (PFC) in VSG animals in comparison to Sham. Further we report diet-driven changes in stress-relevant gene targets in the hypothalamus (oxt, pomc, crhr1) and adrenal (nr3c1, nr3c2, mc2r). Taken together, these data suggest a significant impact of both surgical weight loss and diet on the HPA axis and further impact on behavior. Additional assessment is necessary to determine whether molecular and hormonal changes of surgical weight loss are the source of these findings.
C1 [Himel, Alexandra R.; Grayson, Bernadette E.] Univ Mississippi, Med Ctr, Dept Neurobiol & Anat Sci, Jackson, MS 39216 USA.
   [Cabral, Sharon A.; Shaffery, James P.] Univ Mississippi, Med Ctr, Dept Psychiat & Human Behav, Jackson, MS 39216 USA.
C3 University of Mississippi Medical Center; University of Mississippi;
   University of Mississippi; University of Mississippi Medical Center
RP Grayson, BE (corresponding author), Univ Mississippi, Med Ctr, Dept Neurobiol & Anat Sci, Jackson, MS 39216 USA.
EM bgrayson@umc.edu
FU Department of Defense [SC150016]; National Institute of General Medical
   Sciences [P20GM104357, P20GM121334]; National Institute of General
   Medical Sciences of the National Institutes of Health, Center for
   Psychiatric Neuroscience (CPN)-COBRE [P30GM103328]
FX BEG is supported by the Department of Defense Award Number SC150016 and
   partially by the National Institute of General Medical Sciences Award
   Number P20GM104357 and P20GM121334. The content is solely the
   responsibility of the authors and does not necessarily represent the
   official views of the National Institutes of Health. The work performed
   by SAC and JPS is through the Animal Behavior Core supported, in part,
   by funds from the National Institute of General Medical Sciences of the
   National Institutes of Health, Center for Psychiatric Neuroscience
   (CPN)-COBRE (P30GM103328). The funders had no role in study design, data
   collection and analysis, decision to publish, or preparation of the
   manuscript.
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NR 64
TC 5
Z9 6
U1 0
U2 8
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JUL 6
PY 2018
VL 13
IS 7
AR e0200026
DI 10.1371/journal.pone.0200026
PG 17
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Science & Technology - Other Topics
GA GM1FJ
UT WOS:000437809500054
PM 29979735
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Scott, JM
   Koelwyn, GJ
   Hornsby, WE
   Khouri, M
   Peppercorn, J
   Douglas, PS
   Jones, LW
AF Scott, Jessica M.
   Koelwyn, Graeme J.
   Hornsby, Whitney E.
   Khouri, Michel
   Peppercorn, Jeffrey
   Douglas, Pamela S.
   Jones, Lee W.
TI Exercise Therapy as Treatment for Cardiovascular and Oncologic Disease
   After a Diagnosis of Early-Stage Cancer
SO SEMINARS IN ONCOLOGY
LA English
DT Review
ID ANDROGEN DEPRIVATION THERAPY; C-REACTIVE PROTEIN; BREAST-CANCER;
   PHYSICAL-ACTIVITY; PROSTATE-CANCER; OXIDATIVE STRESS; POSTMENOPAUSAL
   WOMEN; METABOLIC SYNDROME; AEROBIC EXERCISE; LONG-TERM
C1 [Scott, Jessica M.] NASA, Lyndon B Johnson Space Ctr, Houston, TX 77058 USA.
   [Scott, Jessica M.] Univ Space Res Assoc, Houston, TX USA.
   [Koelwyn, Graeme J.] Univ British Columbia, Sch Hlth & Exercise Sci, Kelowna, BC, Canada.
   [Hornsby, Whitney E.; Khouri, Michel; Peppercorn, Jeffrey; Douglas, Pamela S.; Jones, Lee W.] Duke Univ, Med Ctr, Durham, NC USA.
C3 National Aeronautics & Space Administration (NASA); NASA Johnson Space
   Center; Universities Space Research Association (USRA); University of
   British Columbia; Duke University
RP Jones, LW (corresponding author), Duke Canc Inst, Box 3085, Durham, NC 27710 USA.
EM lee.w.jones@duke.edu
RI Douglas, Pamela/B-3264-2013; Peppercorn, Jeffrey/GPX-3100-2022
OI Koelwyn, Graeme/0000-0002-3476-0919; Scott, Jessica/0000-0002-4845-5800;
   Khouri, Michel/0009-0002-6235-5176; Douglas, Pamela/0000-0001-9876-4049
FU National Institutes of Health [CA143254, CA142566, CA138634, CA133895]
FX L.W.J. was supported by National Institutes of Health grants no.
   CA143254, CA142566, CA138634, and CA133895 and with funds from George
   and Susan Beischer. The other authors report no potential conflicts of
   interest.
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NR 118
TC 29
Z9 31
U1 0
U2 16
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0093-7754
EI 1532-8708
J9 SEMIN ONCOL
JI Semin. Oncol.
PD APR
PY 2013
VL 40
IS 2
BP 218
EP 228
DI 10.1053/j.seminoncol.2013.01.001
PG 11
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA 129VA
UT WOS:000317870900010
PM 23540747
DA 2025-06-11
ER

PT J
AU Hills, RD
   Pontefract, BA
   Mishcon, HR
   Black, CA
   Sutton, SC
   Theberge, CR
AF Hills, Ronald D., Jr.
   Pontefract, Benjamin A.
   Mishcon, Hillary R.
   Black, Cody A.
   Sutton, Steven C.
   Theberge, Cory R.
TI Gut Microbiome: Profound Implications for Diet and Disease
SO NUTRIENTS
LA English
DT Review
DE gut microbiota; nutrition; habitual diets; Western diet; obesity;
   cardiometabolic risk factors; chronic health conditions;
   gastrointestinal disorders; prebiotics and probiotics
ID IRRITABLE-BOWEL-SYNDROME; CHAIN FATTY-ACIDS; PROTON PUMP INHIBITORS;
   LACTOBACILLUS-RHAMNOSUS GG; AUTISM SPECTRUM DISORDER; INTESTINAL
   MICROBIOTA; RED MEAT; CARDIOVASCULAR EVENTS; INSULIN-RESISTANCE;
   METABOLIC SYNDROME
AB The gut microbiome plays an important role in human health and influences the development of chronic diseases ranging from metabolic disease to gastrointestinal disorders and colorectal cancer. Of increasing prevalence in Western societies, these conditions carry a high burden of care. Dietary patterns and environmental factors have a profound effect on shaping gut microbiota in real time. Diverse populations of intestinal bacteria mediate their beneficial effects through the fermentation of dietary fiber to produce short-chain fatty acids, endogenous signals with important roles in lipid homeostasis and reducing inflammation. Recent progress shows that an individual's starting microbial profile is a key determinant in predicting their response to intervention with live probiotics. The gut microbiota is complex and challenging to characterize. Enterotypes have been proposed using metrics such as alpha species diversity, the ratio of Firmicutes to Bacteroidetes phyla, and the relative abundance of beneficial genera (e.g., Bifidobacterium, Akkermansia) versus facultative anaerobes (E. coli), pro-inflammatory Ruminococcus, or nonbacterial microbes. Microbiota composition and relative populations of bacterial species are linked to physiologic health along different axes. We review the role of diet quality, carbohydrate intake, fermentable FODMAPs, and prebiotic fiber in maintaining healthy gut flora. The implications are discussed for various conditions including obesity, diabetes, irritable bowel syndrome, inflammatory bowel disease, depression, and cardiovascular disease.
C1 [Hills, Ronald D., Jr.; Mishcon, Hillary R.; Black, Cody A.; Sutton, Steven C.; Theberge, Cory R.] Univ New England, Dept Pharmaceut Sci, Coll Pharm, Portland, ME 04103 USA.
   [Pontefract, Benjamin A.] Boise Vet ff airs Med Ctr, Pharm Serv, Boise, ID 83702 USA.
   [Pontefract, Benjamin A.] Ferris State Univ, Coll Pharm, Big Rapids, MI 49307 USA.
   [Black, Cody A.] Univ Texas Austin, Coll Pharm, San Antonio, TX 78229 USA.
C3 University of New England - Maine; Ferris State University; University
   of Texas System; University of Texas Austin
RP Hills, RD (corresponding author), Univ New England, Dept Pharmaceut Sci, Coll Pharm, Portland, ME 04103 USA.
EM rhills@une.edu
RI Black, Cody/X-7351-2019; Hills, Jr., Ronald D./C-4848-2011
OI Hills, Jr., Ronald D./0000-0003-0352-0020; sutton,
   steven/0000-0002-6349-0356
FU American Foundation for Pharmaceutical Education-Gateway to Research
   Award; National Science Foundation [MCB 1516826]
FX C.A.B. received funding from the American Foundation for Pharmaceutical
   Education-Gateway to Research Award. R.D.H. acknowledges financial
   support from the National Science Foundation, grant MCB 1516826. This
   paper is dedicated to the memory of Dan Veilleux.
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NR 324
TC 711
Z9 779
U1 17
U2 599
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JUL
PY 2019
VL 11
IS 7
AR 1613
DI 10.3390/nu11071613
PG 40
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA IN7TT
UT WOS:000478885400124
PM 31315227
OA gold, Green Published
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Miao, GH
   Deen, J
   Struzeski, JB
   Chen, MJ
   Zhang, Y
   Cole, SA
   Fretts, AM
   Lee, ET
   Howard, B
   Fiehn, O
   Zhao, JY
AF Miao, Guanhong
   Deen, Jason
   Struzeski, Joseph B.
   Chen, Mingjing
   Zhang, Ying
   Cole, Shelley A.
   Fretts, Amanda M.
   Lee, Elisa T.
   Howard, Barbara, V
   Fiehn, Oliver
   Zhao, Jinying
TI Plasma lipidomic profile of depressive symptoms: a longitudinal study in
   a large sample of community-dwelling American Indians in the strong
   heart study
SO MOLECULAR PSYCHIATRY
LA English
DT Article
ID CARDIOVASCULAR-DISEASE RISK; C-REACTIVE PROTEIN; METABOLIC SYNDROME;
   MULTIPLE IMPUTATION; SERUM-CHOLESTEROL; MAJOR DEPRESSION; MISSING-DATA;
   CES-D; DISORDER; BRAIN
AB Dyslipidemia has been associated with depression, but individual lipid species associated with depression remain largely unknown. The temporal relationship between lipid metabolism and the development of depression also remains to be determined. We studied 3721 fasting plasma samples from 1978 American Indians attending two exams (2001-2003, 2006-2009, mean similar to 5.5 years apart) in the Strong Heart Family Study. Plasma lipids were repeatedly measured by untargeted liquid chromatography-mass spectrometry (LC-MS). Depressive symptoms were assessed using the 20-item Center for Epidemiologic Studies for Depression (CES-D). Participants at risk for depression were defined as total CES-D score >= 16. Generalized estimating equation (GEE) was used to examine the associations of lipid species with incident or prevalent depression, adjusting for covariates. The associations between changes in lipids and changes in depressive symptoms were additionally adjusted for baseline lipids. We found that lower levels of sphingomyelins and glycerophospholipids and higher level of lysophospholipids were significantly associated with incident and/or prevalent depression. Changes in sphingomyelins, glycerophospholipids, acylcarnitines, fatty acids and triacylglycerols were associated with changes in depressive symptoms and other psychosomatic traits. We also identified differential lipid networks associated with risk of depression. The observed alterations in lipid metabolism may affect depression through increasing the activities of acid sphingomyelinase and phospholipase A2, disturbing neurotransmitters and membrane signaling, enhancing inflammation, oxidative stress, and lipid peroxidation, and/or affecting energy storage in lipid droplets or membrane formation. These findings illuminate the mechanisms through which dyslipidemia may contribute to depression and provide initial evidence for targeting lipid metabolism in developing preventive and therapeutic interventions for depression.
C1 [Miao, Guanhong; Struzeski, Joseph B.; Chen, Mingjing; Zhao, Jinying] Univ Florida, Dept Epidemiol, Coll Publ Hlth & Hlth Profess, Gainesville, FL 32611 USA.
   [Miao, Guanhong; Struzeski, Joseph B.; Chen, Mingjing; Zhao, Jinying] Univ Florida, Coll Med, Gainesville, FL 32611 USA.
   [Miao, Guanhong; Struzeski, Joseph B.; Chen, Mingjing; Zhao, Jinying] Univ Florida, Ctr Genet Epidemiol & Bioinformat, Gainesville, FL 32611 USA.
   [Deen, Jason] Univ Washington, Dept Pediat, Seattle, WA 98195 USA.
   [Zhang, Ying; Lee, Elisa T.] Univ Oklahoma, Hlth Sci Ctr, Dept Biostat & Epidemiol, Oklahoma City, OK USA.
   [Cole, Shelley A.] Texas Biomed Res Inst, San Antonio, TX USA.
   [Fretts, Amanda M.] Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA.
   [Howard, Barbara, V] MedStar Hlth Res Inst, Hyattsville, MD USA.
   [Fiehn, Oliver] Univ Calif Davis, West Coast Metabol Ctr, Davis, CA 95616 USA.
C3 State University System of Florida; University of Florida; State
   University System of Florida; University of Florida; State University
   System of Florida; University of Florida; University of Washington;
   University of Washington Seattle; University of Oklahoma System;
   University of Oklahoma Health Sciences Center; Texas Biomedical Research
   Institute; University of Washington; University of Washington Seattle;
   MedStar Health Research Institute; University of California System;
   University of California Davis
RP Zhao, JY (corresponding author), Univ Florida, Dept Epidemiol, Coll Publ Hlth & Hlth Profess, Gainesville, FL 32611 USA.; Zhao, JY (corresponding author), Univ Florida, Coll Med, Gainesville, FL 32611 USA.; Zhao, JY (corresponding author), Univ Florida, Ctr Genet Epidemiol & Bioinformat, Gainesville, FL 32611 USA.
EM jzhao66@ufl.edu
RI CHEN, MINGJING/KIH-4903-2024; Fiehn, Oliver/AFO-9881-2022; Miao,
   Guanhong/ADJ-4010-2022
OI Miao, Guanhong/0000-0002-8083-7032; Fiehn, Oliver/0000-0002-6261-8928
FU National Institute of Health (NIH) [R01DK107532]; National Heart, Lung,
   and Blood Institute, National Institute of Health, Department of Health
   and Human Services [75N92019D00027, 75N92019D00028, 75N92019D00029,
   75N92019D00030];  [R01HL109315];  [R01HL109301];  [R01HL109284]; 
   [R01HL109282];  [R01HL109319];  [U01HL41642];  [U01HL41652]; 
   [U01HL41654];  [U01HL65520];  [U01HL65521]
FX This study was supported by the National Institute of Health (NIH) grant
   R01DK107532. The Strong Heart Study (SHS) has been funded in whole or in
   part with federal funds from the National Heart, Lung, and Blood
   Institute, National Institute of Health, Department of Health and Human
   Services, under contract numbers 75N92019D00027, 75N92019D00028,
   75N92019D00029, and 75N92019D00030. The study was previously supported
   by research grants: R01HL109315, R01HL109301, R01HL109284, R01HL109282,
   and R01HL109319 and by cooperative agreements: U01HL41642, U01HL41652,
   U01HL41654, U01HL65520, and U01HL65521.
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NR 81
TC 16
Z9 16
U1 2
U2 23
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 1359-4184
EI 1476-5578
J9 MOL PSYCHIATR
JI Mol. Psychiatr.
PD JUN
PY 2023
VL 28
IS 6
BP 2480
EP 2489
DI 10.1038/s41380-023-01948-w
EA JAN 2023
PG 10
WC Biochemistry & Molecular Biology; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Neurosciences & Neurology; Psychiatry
GA W5OF9
UT WOS:000928330100003
PM 36653676
OA Green Accepted, Green Submitted
DA 2025-06-11
ER

PT J
AU Gaughran, F
   Stahl, D
   Ismail, K
   Atakan, Z
   Lally, J
   Gardner-Sood, P
   Patel, A
   David, A
   Hopkins, D
   Harries, B
   Lowe, P
   Orr, D
   Arbuthnot, M
   Murray, RM
   Greenwood, KE
   Smith, S
AF Gaughran, Fiona
   Stahl, Daniel
   Ismail, Khalida
   Atakan, Zerrin
   Lally, John
   Gardner-Sood, Poonam
   Patel, Anita
   David, Anthony
   Hopkins, David
   Harries, Bee
   Lowe, Philippa
   Orr, Diana
   Arbuthnot, Maurice
   Murray, Robin M.
   Greenwood, Kathryn E.
   Smith, Shubulade
TI Improving physical health and reducing substance use in psychosis -
   randomised control trial (IMPACT RCT): study protocol for a cluster
   randomised controlled trial
SO BMC PSYCHIATRY
LA English
DT Article
DE Severe mental illness; Schizophrenia; Psychosis; Metabolic syndrome;
   Health promotion; Randomised controlled trial
ID CORONARY-HEART-DISEASE; SEVERE MENTAL-ILLNESS; METABOLIC SYNDROME;
   CANNABIS USE; SCHIZOPHRENIA-PATIENTS; CONSORT STATEMENT; TOBACCO
   SMOKING; CLINICAL-TRIALS; FOLLOW-UP; RISK
AB Background: Cardiovascular morbidity and mortality is increased in individuals with severe mental illnesses. We set out to establish a multicentre, two arm, parallel cluster randomized controlled trial (RCT) of a health promotion intervention (HPI), IMPACT Therapy. The patient-tailored IMPACT Therapy aims to target one or more health behaviours from a pre-defined list that includes cannabis use; alcohol use; other substance use; cigarette smoking; exercise; diet and diabetic control, prioritising those identified as problematic by the patient, taking a motivational interviewing and CBT approach. Methods: Impact therapy will be delivered by care coordinators in the community to the treatment group and will be compared to treatment as usual (TAU). The main hypothesis is that the addition of IMPACT Therapy (HPI) to TAU will be more effective than TAU alone in improving patients' quality of life as measured by the Short Form-36, including mental health and physical health subscales on completion of the intervention at 12 months post randomisation. A subsidiary hypothesis will be that addition of IMPACT Therapy (HPI) will be more cost-effective than TAU alone in improving health in people with SMI 12 months from baseline. The IMPACT therapy patient groups' improvement in quality of life, as well as its cost effectiveness, is hypothesised to be maintained at 15 months. Outcomes will be analyzed on an intention-to-treat (ITT) basis.
   Discussion: The results of the trial will provide information about the effectiveness of the IMPACT therapy programme in supporting community mental health teams to address physical comorbidity in severe mental illness.
C1 [Gaughran, Fiona; Lally, John; Murray, Robin M.] South London & Maudsley NHS Fdn Trust, Natl Psychosis Serv, London, England.
   [Gaughran, Fiona] South London & Maudsley NHS Fdn Trust, BRC Nucleus, Maudsley Hosp, Inst Psychiat & Biomed Res Ctr, London, England.
   [Stahl, Daniel] Kings Coll London, Inst Psychiat, Dept Biostat, London WC2R 2LS, England.
   [Ismail, Khalida; David, Anthony; Murray, Robin M.; Smith, Shubulade] Kings Coll London, Inst Psychiat, London WC2R 2LS, England.
   [Ismail, Khalida] NHS Fdn Trust, Kings Coll Hosp London, London, England.
   [Atakan, Zerrin] Kings Coll London, Inst Psychiat, Dept Psychosis Studies, Sect Neuroimaging, London WC2R 2LS, England.
   [Lally, John; Gardner-Sood, Poonam] Kings Coll London, Inst Psychiat, Dept Psychosis Studies, London WC2R 2LS, England.
   [Patel, Anita] Kings Coll London, Inst Psychiat, Ctr Econ Mental & Phys Hlth, London WC2R 2LS, England.
   [Hopkins, David] NHS Fdn Trust, Kings Coll Hosp London, Div Ambulatory Care & Local Networks, London, England.
   [Hopkins, David] Kings Coll London, Sch Med, London WC2R 2LS, England.
   [Harries, Bee; Lowe, Philippa; Orr, Diana; Arbuthnot, Maurice] Royal Free & Univ Coll Med Sch, Dept Mental Hlth Sci, London WC1E 6BT, England.
   [Greenwood, Kathryn E.] Univ Sussex, Sch Psychol, Brighton, E Sussex, England.
   [Greenwood, Kathryn E.] Sussex Partnership NHS Fdn Trust, Early Intervent Psychosis Serv, Worthing, W Sussex, England.
   [Smith, Shubulade] South London & Maudsley NHS Fdn Trust, London, England.
C3 South London & Maudsley NHS Trust; South London & Maudsley NHS Trust;
   Maudsley Hospital; University of London; King's College London;
   University of London; King's College London; Oxford University Hospitals
   NHS Foundation Trust; King's College Hospital NHS Foundation Trust;
   King's College Hospital; University of London; King's College London;
   University of London; King's College London; University of London;
   King's College London; Oxford University Hospitals NHS Foundation Trust;
   King's College Hospital NHS Foundation Trust; King's College Hospital;
   University of London; King's College London; University of London;
   University College London; University of Sussex; South London & Maudsley
   NHS Trust
RP Gaughran, F (corresponding author), South London & Maudsley NHS Fdn Trust, Natl Psychosis Serv, Denmark Hill, London, England.
EM fiona.1.gaughran@kcl.ac.uk
RI Gaughran, Fiona/AAC-7160-2019; greenwood, kathryn/I-8638-2012; Hopkins,
   David/AAP-4541-2020; David, Anthony/O-1750-2019; Patel,
   Anita/F-9832-2010; David, Anthony/C-1315-2011; murray,
   robin/F-8658-2012; Stahl, Daniel/B-9713-2011; Gaughran,
   Fiona/H-5495-2011
OI Ismail, Khalida/0000-0001-6084-449X; David, Anthony/0000-0003-0967-774X;
   murray, robin/0000-0003-0829-0519; Patel, Anita/0000-0003-0769-1732;
   Greenwood, Kathryn/0000-0001-7899-8980; Stahl,
   Daniel/0000-0001-7987-6619; Hopkins, David/0000-0002-0451-0900; Lally,
   John/0000-0003-3038-0625; Gaughran, Fiona/0000-0001-7414-5569
FU National Institute for Health Research funds the IMPACT programme at
   King's College London; South London and Maudsley NHS Foundation Trust
   [RP-PG-0606-1049]; National Institutes of Health Research (NIHR)
   [RP-PG-0606-1049] Funding Source: National Institutes of Health Research
   (NIHR)
FX The National Institute for Health Research funds the IMPACT programme at
   King's College London and South London and Maudsley NHS Foundation Trust
   (ref: RP-PG-0606-1049).
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NR 72
TC 25
Z9 26
U1 1
U2 35
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-244X
J9 BMC PSYCHIATRY
JI BMC Psychiatry
PD OCT 16
PY 2013
VL 13
AR 263
DI 10.1186/1471-244X-13-263
PG 10
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 243CR
UT WOS:000326294700002
PM 24131496
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Ellulu, MS
   Patimah, I
   Khaza'ai, H
   Rahmat, A
   Abed, Y
AF Ellulu, Mohammed S.
   Patimah, Ismail
   Khaza'ai, Huzwah
   Rahmat, Asmah
   Abed, Yehia
TI Obesity and inflammation: the linking mechanism and the complications
SO ARCHIVES OF MEDICAL SCIENCE
LA English
DT Article
DE obesity; inflammation; interleukin 6; C reactive protein; adiponectin;
   linking mechanism
ID C-REACTIVE PROTEIN; CORONARY-HEART-DISEASE; VASCULAR ENDOTHELIAL-CELLS;
   PLASMA ADIPONECTIN LEVELS; APPARENTLY HEALTHY-MEN; BODY-MASS INDEX;
   ADIPOSE-TISSUE; CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; SYSTEMIC
   INFLAMMATION
AB Obesity is the accumulation of abnormal or excessive fat that may interfere with the maintenance of an optimal state of health. The excess of macronu-trients in the adipose tissues stimulates them to release inflammatory mediators such as tumor necrosis factor a and interleukin 6, and reduces production of adiponectin, predisposing to a pro-inflammatory state and oxidative stress. The increased level of interleukin 6 stimulates the liver to synthesize and secrete C-reactive protein. As a risk factor, inflammation is an imbedded mechanism of developed cardiovascular diseases including coagulation, atherosclerosis, metabolic syndrome, insulin resistance, and diabetes mellitus. It is also associated with development of non-cardiovascular diseases such as psoriasis, depression, cancer, and renal diseases. On the other hand, a reduced level of adiponectin, a significant predictor of cardiovascular mortality, is associated with impaired fasting glucose, leading to type-2 diabetes development, metabolic abnormalities, coronary artery calcification, and stroke. Finally, managing obesity can help reduce the risks of cardiovascular diseases and poor outcome via inhibiting inflammatory mechanisms.
C1 [Ellulu, Mohammed S.] Univ Putra Malaysia UPM, Fac Med & Hlth Sci, Dept Nutr & Dietet, Serdang, Malaysia.
   [Patimah, Ismail; Khaza'ai, Huzwah] Univ Putra Malaysia UPM, Fac Med & Hlth Sci, Dept Biomed Sci, Serdang 43300, Malaysia.
   [Rahmat, Asmah] Univ Putra Malaysia UPM, Fac Med & Hlth Sci, Canc Resource & Educ Ctr CARE, Serdang, Malaysia.
   [Abed, Yehia] Al Quds Univ Gaza, Fac Publ Hlth, Gaza, Palestine.
C3 Universiti Putra Malaysia; Universiti Putra Malaysia; Universiti Putra
   Malaysia; Al-Quds University
RP Patimah, I (corresponding author), Univ Putra Malaysia UPM, Fac Med & Hlth Sci, Dept Biomed Sci, Serdang 43300, Malaysia.
EM patimahismail@gmail.com
RI Sandrasaigaran, Pratheep/G-2122-2018; Ellulu, Mohammed S./O-4466-2014
OI Abed, Yehia/0000-0002-8613-2973; Ellulu, Mohammed S./0000-0003-1671-799X
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NR 137
TC 1255
Z9 1367
U1 12
U2 78
PU TERMEDIA PUBLISHING HOUSE LTD
PI POZNAN
PA KLEEBERGA ST 2, POZNAN, 61-615, POLAND
SN 1734-1922
EI 1896-9151
J9 ARCH MED SCI
JI Arch. Med. Sci.
PY 2017
VL 13
IS 4
BP 851
EP 863
DI 10.5114/aoms.2016.58928
PG 13
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA FD0ZV
UT WOS:000407268100020
PM 28721154
OA gold, Green Published, Green Submitted
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Farhangi, MA
AF Farhangi, Mahdieh Abbasalizad
TI Dietary total antioxidant capacity significantly interacts with 6-P21
   rs2010963 gene polymorphisms in terms of cardio-metabolic risk factors
   in patients with metabolic syndrome
SO BMC RESEARCH NOTES
LA English
DT Article
DE Dietary antioxidant capacity; Metabolic syndrome
ID QUALITY SCORE DAQS; INSULIN-RESISTANCE; GENDER-DIFFERENCES; OXIDATIVE
   STRESS; ASSOCIATION; FOOD; POPULATION; PREVALENCE
AB Objective Gene- nutrient interaction might possibly be involved in the pathogenesis of metabolic syndrome and its components. In the current report, the association between antioxidant potential of the diet with 6P21 rs2010963 gene polymorphism in patients with metabolic syndrome has been evaluated. Two hundred fifty-four patients with metabolic syndrome were enrolled. Total dietary antioxidant capacity (TAC) has been estimated and anthropometric assessments were assessed. Biochemical assays including serum glucose, matrix metalloproteinase-3, liver enzymes and lipid profiles were also assessed. Polymerase chain reaction- restriction fragment length polymorphism (PCR-RFLP) method was used for determination of 6P21 rs2010963 polymorphism. Results Dietary vitamin E score was significantly higher in GC genotype compared with other genotypes (P = 0.035). Patients in CC genotype of 6P21 rs2010963 had significantly higher body mass index (BMI), fasting blood sugar and liver enzymes (P < 0.05). Being in the higher dietary TAC scores was also associated with lower liver enzymes. The interaction between 6P21 rs2010963 and dietary TAC significantly affected BMI, FBS and diastolic blood pressure (P < 0.05). According to our findings the CC genotype of 6P21 rs2010963 could be considered as the possible risk factor for obesity and metabolic disorders among patients with metabolic syndrome.
C1 [Farhangi, Mahdieh Abbasalizad] Tabriz Univ Med Sci, Nutr Res Ctr, Tabriz, Iran.
   [Farhangi, Mahdieh Abbasalizad] Tabriz Univ Med Sci, Drug Appl Res Ctr, Tabriz, Iran.
C3 Tabriz University of Medical Science; Tabriz University of Medical
   Science
RP Farhangi, MA (corresponding author), Tabriz Univ Med Sci, Nutr Res Ctr, Tabriz, Iran.
EM abbasalizad_m@yahoo.com
RI Farhangi, Mahdieh/AAC-6758-2019
FU Tabriz University of Medical Sciences
FX The current research was supported by research undersecretary of Tabriz
   University of Medical Sciences.
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NR 41
TC 5
Z9 5
U1 0
U2 0
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
EI 1756-0500
J9 BMC RES NOTES
JI BMC Res. Notes
PD MAR 11
PY 2020
VL 13
IS 1
AR 145
DI 10.1186/s13104-020-04993-8
PG 8
WC Biology; Multidisciplinary Sciences
WE Emerging Sources Citation Index (ESCI)
SC Life Sciences & Biomedicine - Other Topics; Science & Technology - Other
   Topics
GA KU6KA
UT WOS:000519822600004
PM 32160900
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Matera, E
   Cristofano, G
   Furente, F
   Marzulli, L
   Tarantini, M
   Margari, L
   Piarulli, FM
   De Giacomo, A
   Petruzzelli, MG
AF Matera, Emilia
   Cristofano, Gloria
   Furente, Flora
   Marzulli, Lucia
   Tarantini, Martina
   Margari, Lucia
   Piarulli, Francesco Maria
   De Giacomo, Andrea
   Petruzzelli, Maria Giuseppina
TI Glucose and Lipid Profiles Predict Anthropometric Changes in Drug-Naive
   Adolescents Starting Treatment with Risperidone or Sertraline: A Pilot
   Study
SO BIOMEDICINES
LA English
DT Article
DE second-generation antipsychotics; risperidone; sertraline; selective
   serotonin reuptake inhibitors; metabolic risk; anthropometric changes;
   glucose profile; lipid profile; weight gain; drug-naive adolescents
ID SEROTONIN REUPTAKE INHIBITORS; INDUCED WEIGHT-GAIN; METABOLIC SYNDROME;
   CARDIOMETABOLIC RISK; PSYCHOTIC DISORDERS; MENTAL-ILLNESS; DEPRESSION;
   SCHIZOPHRENIA; CHILDREN; PEOPLE
AB Psychiatric disorders are associated with cardiometabolic diseases, partly due to adverse drug effects with individual risk variabilities. Risperidone and sertraline are widely used for youths. Although they may be exposed to anthropometric changes, few data about this population exist. We evaluated the correlation between several blood parameters and body changes in a very small group of drug-naive adolescents who had started risperidone or sertraline. We examined weight, waist circumference (WC), WC/height ratio and body mass index (BMI) at baseline (T0) and after at least three months of therapy (T1), and blood glucose and lipid profiles at T0. Here, we show significant increases in several anthropometric parameters in both groups, a negative correlation between HDL and Delta WC in the risperidone group and positive correlations between insulin and Delta BMI and between HOMA-IR and Delta BMI in the sertraline group. Despite the sample size, these results are important because it is difficult to study adolescents who are long-term-compliant with psychotropic drugs. This pilot study supports the importance of future large-scale investigations to understand the metabolic risk profiles of psychotropic drugs, their individual vulnerabilities and their underlying mechanisms. Simultaneous guideline-based psychiatric and metabolic interventions should be part of daily practice.
C1 [Matera, Emilia; Margari, Lucia] Univ Bari Aldo Moro, DiMePRe J Dept Precis & Rigenerat Med Jon Area, I-70100 Bari, Italy.
   [Cristofano, Gloria; Furente, Flora; Marzulli, Lucia; Tarantini, Martina; Piarulli, Francesco Maria; De Giacomo, Andrea; Petruzzelli, Maria Giuseppina] Univ Bari Aldo Moro, DiBraiN Dept Translat Biomed Neurosci, I-70100 Bari, Italy.
C3 Universita degli Studi di Bari Aldo Moro; Universita degli Studi di Bari
   Aldo Moro
RP Matera, E (corresponding author), Univ Bari Aldo Moro, DiMePRe J Dept Precis & Rigenerat Med Jon Area, I-70100 Bari, Italy.
EM emilia.matera@uniba.it
RI Margari, Lucia/AAK-4375-2021; matera, emilia/GVT-0488-2022; Margari,
   Lucia/K-8857-2016
OI Piarulli, Francesco Maria/0000-0003-3209-3478; petruzzelli, maria
   giuseppina/0000-0003-1734-788X; De Giacomo, Andrea/0000-0002-3454-1679;
   Matera, Emilia/0000-0002-7541-0616; Marzulli, Lucia/0000-0002-7448-1017;
   Furente, Flora/0000-0001-7081-2520; Margari, Lucia/0000-0002-9203-3373
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NR 68
TC 3
Z9 3
U1 0
U2 0
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2227-9059
J9 BIOMEDICINES
JI Biomedicines
PD JAN
PY 2023
VL 11
IS 1
AR 48
DI 10.3390/biomedicines11010048
PG 13
WC Biochemistry & Molecular Biology; Medicine, Research & Experimental;
   Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Research & Experimental Medicine;
   Pharmacology & Pharmacy
GA 7X8UF
UT WOS:000914469500001
PM 36672556
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Ishaq, S
   Siyar, S
   Basri, R
   Liaqat, A
   Hameed, A
   Ahmed, T
AF Ishaq, Sara
   Siyar, Sohana
   Basri, Rabia
   Liaqat, Amna
   Hameed, Armeen
   Ahmed, Touqeer
TI Neuroprotective Effects of Shogaol in Metals (Al, As and Pb) and
   High-fat diet-induced Neuroinflammation and Behavior in Mice
SO CURRENT MOLECULAR PHARMACOLOGY
LA English
DT Article
DE Anxiety; neuroinflammation; blood brain barrier; heavy metals; shogaol;
   metabolic profile
ID GINGER ZINGIBER-OFFICINALE; BLOOD-BRAIN-BARRIER; AMYLOID PRECURSOR
   PROTEIN; MORRIS WATER MAZE; HEAVY-METALS; OXIDATIVE STRESS;
   GENE-EXPRESSION; NEUROTROPHIC FACTOR; METABOLIC SYNDROME; ANIMAL-MODELS
AB Background Increased exposure of humans to toxic metals and high-fat diet (HFD) consumption severely damages brain health. Natural plant extracts have shown huge potential to treat multiple human diseases. Objective The present study was designed to evaluate the protective effects of Shogaol (an active component of ginger) in neuroinflammation and behavioral paradigms in mice treated with metals and HFD. Methods 8-11 weeks old male mice model was developed by giving a combination of metals, i.e., Arsenic (As), Lead (Pb) and Aluminum (Al), 25mg/kg each mixed in drinking water with laboratory prepared HFD (40% fat) for a total duration of 72 days. Shogaol treated groups received two doses (2mg/kg & 12mg/kg) of Shogaol along with metals and HFD. The biochemical parameters, including body weights, blood glucose, and kidney and liver functions, were assessed along with the integrity of the blood-brain barrier (BBB). The expression analysis of neuroinflammatory genes (TNF-alpha, IL-1 beta & GFAP) was performed using q-PCR in the hippocampus and cortex. The exploratory and anxiety-like behavior was assessed using an open field test, and depressive behavior was assessed through the forced swim test, while learning and memory were assessed using the Morris water maze test and y-maze test. Results Shogaol (2mg/kg & 12mg/kg) treatment improved metabolic profile and reduced expression of neuroinflammatory genes in the cortex and the hippocampus. Shogaol treatment improved BBB integrity. Results of the behavioral analysis showed that Shogaol treatment (2mg/kg & 12mg/kg) rescued behavioral impairment and improved anxiety and depression. Conclusion Shogaol treatment showed strong therapeutic potential in metals & HFD induced neuroinflammation and improved cognitive functions; thus, can be considered a potential drug candidate in the future.
C1 [Ishaq, Sara; Siyar, Sohana; Basri, Rabia; Liaqat, Amna; Hameed, Armeen; Ahmed, Touqeer] Natl Univ Sci & Technol, Atta ur Rahman Sch Appl Biosci, Dept Healthcare Biotechnol, Neurobiol Lab, Islamabad 44000, Pakistan.
   [Ahmed, Touqeer] Natl Univ Sci & Technol, Atta ur Rahman Sch Appl Biosci, Dept Healthcare Biotechnol, Sect H-12, Islamabad 44000, Pakistan.
C3 National University of Sciences & Technology - Pakistan; National
   University of Sciences & Technology - Pakistan
RP Ahmed, T (corresponding author), Natl Univ Sci & Technol, Atta ur Rahman Sch Appl Biosci, Dept Healthcare Biotechnol, Sect H-12, Islamabad 44000, Pakistan.
EM touqeer.aahmed@gmail.com
RI Ahmed, Touqeer/AAP-2195-2021
OI Ishaq, Sara/0000-0001-9108-9298; Basri, Rabia/0000-0002-6233-7210;
   Liaqat, Amma/0000-0002-9499-9921
FU ASAB, NUST, Islamabad, Pakistan; HEC-NRPU Grant [9780]
FX This research was supported by the MS students' research funds provided
   by ASAB, NUST, Islamabad, Pakistan and HEC-NRPU Grant No. 9780 awarded
   to TA.
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NR 178
TC 8
Z9 9
U1 1
U2 10
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1874-4672
EI 1874-4702
J9 CURR MOL PHARMACOL
JI Curr. Molec. Pharmacol.
PY 2023
VL 16
IS 7
BP 725
EP 750
DI 10.2174/1874467215666220928110557
PG 26
WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
GA I7NZ9
UT WOS:001004630900004
PM 36173059
DA 2025-06-11
ER

PT J
AU Bilu, C
   Kronfeld-Schor, N
   Zimmet, P
   Einat, H
AF Bilu, Carmel
   Kronfeld-Schor, Noga
   Zimmet, Paul
   Einat, Haim
TI Sex differences in the response to circadian disruption in diurnal sand
   rats
SO CHRONOBIOLOGY INTERNATIONAL
LA English
DT Article
DE Circadian rhythms; circadian disruption; type 2 diabetes; depression;
   sex differences
ID ANXIETY-LIKE BEHAVIORS; DEPRESSION-LIKE BEHAVIORS; UNSTRIPED NILE RAT;
   GENDER-DIFFERENCES; METABOLIC SYNDROME; DIABETES-MELLITUS; ACTIVITY
   RHYTHMS; SHORT DAYLIGHT; ANIMAL-MODEL; PHOTOPERIOD
AB Most animal model studies on physiological functions and pathologies are conducted in males. However, diseases such as depression, type 2 diabetes (T2DM) and cardiovascular disease, all show different prevalence and characteristics in females and males. Moreover, most mammal studies are conducted in nocturnal mice and rats, while modelling diurnal humans. We therefore used male and female fat sand rats (Psammomys obesus), which are diurnal in the wild, as an animal model for T2DM, to explore the effects of mild circadian disruption on behavior, glucose tolerance, cholesterol and heart weight. We found significant differences between the sexes: on average, in response to short photoperiods (SP) acclimation, males showed higher levels of depression-like behavior, lower glucose tolerance, and increased plasma cholesterol levels compared with females, with no effect on heart/body weight ratio. Females, however did show an increase in heart/body weight ratio in response to SP acclimation. We also found that regardless of sex, arrhythmic animals showed higher blood glucose levels, cholesterol levels, heart/body weight ratio, and depressive-like behavior compared with rhythmic animals. Hence, we suggest that the expression of the Circadian Syndrome could be different between males and females. Additional work with females is required to clearly delineate the specific effects in both sexes, and promote sex-based health care, prevention measures and therapies.
C1 [Bilu, Carmel; Kronfeld-Schor, Noga] Tel Aviv Univ, Sch Zool, Tel Aviv, Israel.
   [Kronfeld-Schor, Noga] Tel Aviv Univ, Sagol Sch Neurosci, Tel Aviv, Israel.
   [Zimmet, Paul] Monash Univ, Dept Med, Melbourne, Vic, Australia.
   [Einat, Haim] Tel Aviv Yaffo Acad Coll, Sch Behav Sci, Tel Aviv, Israel.
C3 Tel Aviv University; Tel Aviv University; Monash University
RP Bilu, C (corresponding author), Tel Aviv Univ, Sch Zool, Tel Aviv, Israel.
EM Carmel.bilu@gmail.com
RI Kronfeld-Schor, Noga/AAU-3792-2020; Zimmet, Paul/H-7635-2013
OI Kronfeld-Schor, Noga/0000-0002-5224-3341
FU Israel Science Foundation [ISF] [866/17]; United States-Israel
   Binational Science Foundation (BSF) [2015118]
FX This research was supported by the Israel Science Foundation [ISF grant
   No. 866/17] and by Grant No 2015118 from the United States-Israel
   Binational Science Foundation (BSF).
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NR 119
TC 6
Z9 6
U1 0
U2 6
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 0742-0528
EI 1525-6073
J9 CHRONOBIOL INT
JI Chronobiol. Int.
PD FEB 1
PY 2022
VL 39
IS 2
BP 169
EP 185
DI 10.1080/07420528.2021.1989448
EA OCT 2021
PG 17
WC Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics; Physiology
GA YM0FS
UT WOS:000712666600001
PM 34711113
DA 2025-06-11
ER

PT J
AU Dimopoulou, C
   Geraedts, V
   Stella, GK
   Sievers, C
AF Dimopoulou, C.
   Geraedts, V.
   Stella, G. K.
   Sievers, C.
TI Neuropsychiatric and cardiometabolic comorbidities in patients with
   previously diagnosed Cushing's disease: a longitudinal observational
   study
SO BMJ OPEN
LA English
DT Article
ID QUALITY-OF-LIFE; ENDOGENOUS HYPERCORTISOLISM; CLINICAL CHARACTERISTICS;
   CARDIOVASCULAR RISK; QUESTIONNAIRE; COMPLICATIONS; IMPAIRMENT; CURE
AB Introduction: Only few studies have systematically investigated neuropsychiatric aspects in patients with Cushing's disease (CD). Pain syndromes have been described in patients with pituitary adenomas, but so far no systematical investigation has been conducted in patients with CD. Additionally, CD has an association with cardiometabolic comorbidities which ultimately leads to increased morbidity and mortality. Long-term treatment of the hypercortisolic state cannot prevent the persistence of an unfavourable cardiometabolic risk profile. Finally, chronic hypercortisolism is known to impact the health-related quality of life (HRQoL). We aim to systematically investigate the neuropsychiatric and cardiometabolic comorbidities, as well as assess the HRQoL, in patients with previously diagnosed CD in a longitudinal fashion.
   Methods and analysis: In this longitudinal study, we will assess 20 patients with CD displaying biochemical control 24 months after recruitment in the initial cross-sectional study (n=80). This will be a mixed cohort including patients after surgical, after radiation therapy and/or under current medical treatment for CD. Primary outcomes include changes in mean urinary free cortisol and changes in specific pain patterns. Secondary/exploratory neuropsychiatric domains include depression, anxiety, personality, sleep, body image and quality of life. Secondary/exploratory cardiometabolic domains include anthropometric parameters, cardiometabolic risk biomarkers and insulin resistance. Additional domains will be investigated if warranted by clinical indication. Safety assessment under medical therapy will include liver enzymes, ECG abnormalities and hyperglycaemia.
   Ethics and dissemination: Risk of damage from study-conditioned measures is very small and considered ethically justified. Dual-energy X-ray absorptiometry may call for detailed fracture risk assessment. However, the radiation dose is very small and only administered on clinical indication; therefore, it is considered ethically justified. This protocol has been approved by the local medical ethics committee.
C1 [Dimopoulou, C.; Geraedts, V.; Stella, G. K.; Sievers, C.] Max Planck Inst Psychiat, Dept Neuroendocrinol, Munich, Germany.
C3 Max Planck Society
RP Geraedts, V (corresponding author), Max Planck Inst Psychiat, Dept Neuroendocrinol, Munich, Germany.
EM v.j.geraedts@umail.leidenuniv.nl
RI Geraedts, Victor/AAP-9732-2020
OI Geraedts, Victor/0000-0002-6604-8707; Stalla,
   Guenter/0000-0002-1975-3294
FU Novartis, NCC [CSOM230BDE05T]
FX This work was supported by Novartis, NCC-Code: CSOM230BDE05T.
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   Resmini E, 2013, CLIN ENDOCRINOL, V79, P700, DOI 10.1111/cen.12224
   Scillitani A, 2014, OSTEOPOROSIS INT, V25, P441, DOI 10.1007/s00198-013-2588-y
   Tóth M, 2013, CLIN ENDOCRINOL, V79, P1, DOI 10.1111/cen.12189
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   Webb SM, 2008, EUR J ENDOCRINOL, V158, P623, DOI 10.1530/EJE-07-0762
NR 23
TC 1
Z9 1
U1 0
U2 5
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2044-6055
J9 BMJ OPEN
JI BMJ Open
PY 2015
VL 5
IS 3
AR e006134
DI 10.1136/bmjopen-2014-006134
PG 3
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA CU3WZ
UT WOS:000363458200014
PM 25818269
OA Green Published, gold
DA 2025-06-11
ER

PT S
AU Epel, E
   Jimenez, S
   Brownell, K
   Stroud, L
   Stoney, C
   Niaura, R
AF Epel, E
   Jimenez, S
   Brownell, K
   Stroud, L
   Stoney, C
   Niaura, R
BE Yehuda, R
   McEwen, B
TI Are stress eaters at risk for the metabolic syndrome?
SO BIOBEHAVIORAL STRESS RESPONSE: PROTECTIVE AND DAMAGING EFFECTS
SE Annals of the New York Academy of Sciences
LA English
DT Article; Proceedings Paper
CT Conference on Protective and Damaging Effects of the Biobehavioral
   Stress Response
CY SEP 07-09, 2003
CL New York, NY
SP Glaxosmithkline, Janssen Pharmaceut, Pfizer Inc, Solvay, Bristol Myers Squibb, Novartis Pharmaceut, AstraZeneca, Eli Lilly & Co, Johnson & Johnson, Merck, Ortho McNeil Pharmaceut Inc
DE stress; eating; metabolic syndrome; weight gain
AB Stress eating is a health behavior that has been overlooked in much of health psychology research. It is largely unknown why some tend to eat during or after stressful periods, whereas others tend to lose their appetite and lose weight. Furthermore, it is unknown if such transient changes in food intake or macronutrient composition during stress have clinically significant consequences in terms of weight and metabolic health. The Brown University Medical Student Study examined students during a baseline control period as well as during two examination periods. This design enabled an examination of weight changes in self-proclaimed stress eaters vs stress-less eaters over time. Stress eaters tended to gain more weight and demonstrated increases in nocturnal levels of insulin, cortisol, and blood levels of total/HDL cholesterol ratio, during exam periods, controlling for the baseline control period. These data show prospectively that stress eating may indeed have short-term consequences on metabolic health. Future research will need to determine whether this confers a greater risk of disease over time.
C1 Univ Calif San Francisco, Hlth Psychol Program, San Francisco, CA 94143 USA.
C3 University of California System; University of California San Francisco
RP Univ Calif San Francisco, Hlth Psychol Program, 3333 Calif St,Ste 465, San Francisco, CA 94143 USA.
EM elissa@itsa.ucsf.edu
RI Niaura, Raymond/AAE-7319-2019; Stroud, Laura/O-7807-2019; Epel,
   Elissa/ABI-6703-2022; Stoney, Catherine/AAD-7400-2020; Brownell,
   Kelly/H-3649-2014
OI Stroud, Laura/0000-0002-2138-968X
CR Dallman MF, 2003, P NATL ACAD SCI USA, V100, P11696, DOI 10.1073/pnas.1934666100
   Epel E, 2001, PSYCHONEUROENDOCRINO, V26, P37, DOI 10.1016/S0306-4530(00)00035-4
   STONE AA, 1994, PSYCHOL HEALTH, V9, P425, DOI 10.1080/08870449408407469
NR 3
TC 177
Z9 208
U1 1
U2 23
PU NEW YORK ACAD SCIENCES
PI NEW YORK
PA 2 EAST 63RD ST, NEW YORK, NY 10021 USA
SN 0077-8923
BN 1-57331-519-2; 1-57331-518-4
J9 ANN NY ACAD SCI
JI Ann.NY Acad.Sci.
PY 2004
VL 1032
BP 208
EP 210
DI 10.1196/annals.1314.022
PG 3
WC Behavioral Sciences; Endocrinology & Metabolism; Multidisciplinary
   Sciences; Physiology; Psychology
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Behavioral Sciences; Endocrinology & Metabolism; Science & Technology -
   Other Topics; Physiology; Psychology
GA BBW44
UT WOS:000228129700023
PM 15677412
DA 2025-06-11
ER

PT J
AU Shank, LM
   Tanofsky-Kraff, M
   Radin, RM
   Shomaker, LB
   Wilfley, DE
   Young, JF
   Brady, S
   Olsen, CH
   Reynolds, JC
   Yanovski, JA
AF Shank, Lisa M.
   Tanofsky-Kraff, Marian
   Radin, Rachel M.
   Shomaker, Lauren B.
   Wilfley, Denise E.
   Young, Jami F.
   Brady, Sheila
   Olsen, Cara H.
   Reynolds, James C.
   Yanovski, Jack A.
TI Remission of loss of control eating and changes in components of the
   metabolic syndrome
SO INTERNATIONAL JOURNAL OF EATING DISORDERS
LA English
DT Article
DE adolescents; loss of control eating; metabolic syndrome; obesity;
   overweight
ID BECK DEPRESSION INVENTORY; PSYCHOMETRIC PROPERTIES; ADOLESCENT GIRLS;
   WEIGHT-GAIN; HIGH-RISK; CHILDREN; POPULATION; OVERWEIGHT; TRENDS; YOUNG
AB ObjectivePediatric loss of control (LOC) eating prospectively predicts the worsening of metabolic syndrome components. However, it is unknown if remission of LOC eating is associated with improvements in metabolic health. Therefore, we conducted a secondary analysis of a trial that enrolled adolescent girls with LOC eating, examining whether LOC remission (vs. persistence) at end-of-treatment was associated with changes in metabolic syndrome components at 6-month follow-up.
   MethodOne hundred three adolescent girls (age 14.51.7years; BMI-z 1.50.3; 56.3% non-Hispanic White, 24.3% non-Hispanic Black) with elevated weight (75th-97th BMI %ile) and reported LOC eating were assessed for metabolic syndrome components at baseline and again six months following the interventions. The main effects of LOC status at end-of-treatment (persistence vs. remission) on metabolic syndrome components (waist circumference, lipids, glucose, and blood pressure) at 6-month follow-up were examined, adjusting for baseline age, depressive symptoms, LOC frequency, fat mass, and height, as well as race, change in height, change in fat mass, and the baseline value of each respective component.
   ResultsYouth with LOC remission at end-of-treatment had lower glucose (83.9 +/- 6.4 vs. 86.5 +/- 5.8mg/dL; p=.02), higher high-density lipoprotein cholesterol (50.3 +/- 11.8 vs. 44.8 +/- 11.9mg/dL; p=.01), and lower triglycerides (84.4 +/- 46.2 vs. 96.9 +/- 53.7mg/dL; p=.02) at 6-month follow-up when compared with youth with persistent LOC, despite no baseline differences in these components. No other component significantly differed by LOC eating status (ps>.05).
   DiscussionReducing LOC eating in adolescent girls may have a beneficial impact on some components of the metabolic syndrome.
C1 [Shank, Lisa M.; Tanofsky-Kraff, Marian; Radin, Rachel M.] Uniformed Serv Univ Hlth Sci USUHS, Med & Clin Psychol Dept, Bethesda, MD USA.
   [Shank, Lisa M.; Tanofsky-Kraff, Marian; Radin, Rachel M.; Shomaker, Lauren B.; Brady, Sheila; Yanovski, Jack A.] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Sect Growth & Obes, NIH, Bethesda, MD USA.
   [Shank, Lisa M.] Henry M Jackson Fdn Adv Mil Med HJF, Bethesda, MD USA.
   [Shomaker, Lauren B.] Colorado State Univ, Dept Human Dev & Family Studies, Ft Collins, CO 80523 USA.
   [Wilfley, Denise E.] Washington Univ, Sch Med, Dept Psychiat, St Louis, MO 63110 USA.
   [Young, Jami F.] Childrens Hosp Philadelphia, Dept Child & Adolescent Psychiat & Behav Sci, Philadelphia, PA 19104 USA.
   [Olsen, Cara H.] USUHS, Prevent Med & Biostat Dept, Bethesda, MD USA.
   [Reynolds, James C.] NIH, Radiol & Imaging Sci Dept, Ctr Clin, Bldg 10, Bethesda, MD 20892 USA.
   [Radin, Rachel M.] Univ Calif San Francisco, San Francisco Dept Psychiat, Ctr Hlth Community, 3333 Calif St,Suite 465, San Francisco, CA 94118 USA.
C3 National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver
   National Institute of Child Health & Human Development (NICHD); Henry M.
   Jackson Foundation for the Advancement of Military Medicine, Inc;
   Colorado State University System; Colorado State University Fort
   Collins; Washington University (WUSTL); University of Pennsylvania;
   Pennsylvania Medicine; Childrens Hospital of Philadelphia; National
   Institutes of Health (NIH) - USA; NIH Clinical Center (CC); University
   of California System; University of California San Francisco
RP Tanofsky-Kraff, M (corresponding author), USUHS, Dept Med & Clin Psychol, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA.
EM marian.tanofsky-kraff@usuhs.edu
RI Young, Jami/A-1474-2011; Shank, Lisa/I-7079-2015
OI Yanovski, Jack/0000-0001-8542-1637; Radin, Rachel/0000-0003-3776-9481;
   Tanofsky-Kraff, Marian/0000-0003-3871-2233; Shank,
   Lisa/0000-0002-6922-7946
FU NIDDK [1R01DK080906]; USUHS [R072IC]; NICHD Intramural Research Program
   [ZIA-HO-00641]
FX NIDDK, Grant Number: 1R01DK080906; USUHS, Grant Number: R072IC; NICHD
   Intramural Research Program, Grant Number: ZIA-HO-00641
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NR 54
TC 10
Z9 12
U1 0
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0276-3478
EI 1098-108X
J9 INT J EAT DISORDER
JI Int. J. Eating Disord.
PD JUN
PY 2018
VL 51
IS 6
BP 565
EP 573
DI 10.1002/eat.22866
PG 9
WC Psychology, Clinical; Nutrition & Dietetics; Psychiatry; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Nutrition & Dietetics; Psychiatry
GA GJ3YX
UT WOS:000435273600010
PM 29607525
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Bayoumi, E
   Karasik, P
AF Bayoumi, Essraa
   Karasik, Pamela
TI Cardiovascular Disease in Older Women
SO CLINICS IN GERIATRIC MEDICINE
LA English
DT Article
DE Older women; Cardiovascular risk; CVD prevention and treatment
ID CORONARY-HEART-DISEASE; ACUTE MYOCARDIAL-INFARCTION; TYPE-2
   DIABETES-MELLITUS; ESTROGEN PLUS PROGESTIN; GENDER-DIFFERENCES;
   ARTERY-BYPASS; RISK-FACTORS; ELECTROCARDIOGRAPHIC RESPONSE; STRESS
   ECHOCARDIOGRAPHY; METABOLIC SYNDROME
C1 [Bayoumi, Essraa] Georgetown Univ, Medstar Washington Hosp Ctr, VA Med Ctr, 110 Irving St Northwest, Washington, DC 20422 USA.
   [Karasik, Pamela] Med Serv VA Med Ctr, 50 Irving St Northwest 4A 154, Washington, DC 20422 USA.
C3 Georgetown University; MedStar Washington Hospital Center
RP Karasik, P (corresponding author), Med Serv VA Med Ctr, 50 Irving St Northwest 4A 154, Washington, DC 20422 USA.
EM Pamela.karasik@va.gov
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NR 77
TC 7
Z9 7
U1 0
U2 6
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0749-0690
EI 1879-8853
J9 CLIN GERIATR MED
JI Clin. Geriatr. Med.
PD NOV
PY 2021
VL 37
IS 4
BP 651
EP 665
DI 10.1016/j.cger.2021.05.010
EA SEP 2021
PG 15
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA WG2WN
UT WOS:000706858200014
PM 34600729
DA 2025-06-11
ER

PT J
AU Demircan, N
   Gürel, A
   Armutcu, F
   Ünalacak, M
   Aktunç, E
   Atmaca, H
AF Demircan, Nejat
   Gurel, Ahmet
   Armutcu, Ferah
   Unalacak, Murat
   Aktunc, Erol
   Atmaca, Hulusi
TI The evaluation of serum cystatin C, malondialdehyde, and total
   antioxidant status in patients with metabolic syndrome
SO MEDICAL SCIENCE MONITOR
LA English
DT Article
DE metabolic syndrome; cystatin C; malondialdehyde; total antioxidant
   status
ID OXIDATIVE STRESS; RISK-FACTORS; EXPRESSION; ASSOCIATION; VISFATIN;
   DISEASE; APELIN; CANCER; HEART
AB Background: This study was designed to determine if serum cystatin C (Cys C) levels are affected by metabolic syndome and whether they correlate with lipid peroxidation and total antioxidant status (TAS) in this disorder.
   Material/Methods: Cases with metabolic syndrome diagnosed according to the ATP III criteria (18 females, 12 males) were compared with healthy control subjects (20 females, 17 males) matched by age and gender. Plasma Cys C, malondialdehyde (NIDA), and TAS levels were studied.
   Results: Compared with the controls, Cys C and MDA levels were significantly higher (p < 0.001 and p < 0.001, respectively), whereas TAS was lower (p < 0.001) in metabolic syndrome patients. A significant positive correlation between MDA and Cys C (r=0.308, p < 0.05) and a significant negative correlation between TAS and Cys C levels (r=0.358, p < 0.01) were found.
   Conclusions: As Cys C and MDA levels increased but TAS decreased, Cys C may be an important indicator in the pathogenesis of metabolic syndrome.
C1 [Demircan, Nejat; Unalacak, Murat; Aktunc, Erol] Zonguldak Karaelmas Univ, Fac Med, Dept Family Med, Zonguldak, Turkey.
   [Gurel, Ahmet; Armutcu, Ferah] Zonguldak Karaelmas Univ, Fac Med, Dept Biochem, Zonguldak, Turkey.
   [Atmaca, Hulusi] Zonguldak Karaelmas Univ, Fac Med, Dept Endocrinol, Zonguldak, Turkey.
C3 Zonguldak Bulent Ecevit University; Zonguldak Bulent Ecevit University;
   Zonguldak Bulent Ecevit University
RP Demircan, N (corresponding author), Zonguldak Karaelmas Univ, Tip Fak, Aile Hekimligi Anabilim Dali, TR-67600 Kozlu, Zonguldak, Turkey.
EM nejatdemircantr@yahoo.com
RI Armutcu, Ferah/A-1364-2019; aktunç, erol/AAB-4950-2021
OI Atmaca, Mehmet Hulusi/0009-0009-0158-7804; Demircan,
   Nejat/0000-0002-0513-058X
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NR 40
TC 62
Z9 74
U1 0
U2 11
PU INT SCIENTIFIC INFORMATION, INC
PI MELVILLE
PA 150 BROADHOLLOW RD, STE 114, MELVILLE, NY 11747 USA
SN 1643-3750
J9 MED SCI MONITOR
JI Med. Sci. Monitor
PD FEB
PY 2008
VL 14
IS 2
BP CR97
EP CR101
PG 5
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 264MW
UT WOS:000253292900012
PM 18227768
DA 2025-06-11
ER

PT J
AU Munekata, PES
   Pateiro, M
   Zhang, WG
   Dominguez, R
   Xing, LJ
   Fierro, EM
   Lorenzo, JM
AF Munekata, Paulo E. S.
   Pateiro, Mirian
   Zhang, Wangang
   Dominguez, Ruben
   Xing, Lujuan
   Fierro, Elena Movilla
   Lorenzo, Jose M.
TI Health benefits, extraction and development of functional foods with
   curcuminoids
SO JOURNAL OF FUNCTIONAL FOODS
LA English
DT Article
DE Turmeric; Curcumin; Green extraction technologies; Cardiovascular
   diseases; Diabetes; Arthritis; Emulsion
ID RHEUMATOID-ARTHRITIS PATIENTS; HIGHLY-BIOAVAILABLE CURCUMIN;
   DOUBLE-BLIND; METABOLIC SYNDROME; MAJOR DEPRESSION; OXIDATIVE STRESS;
   RISK-FACTORS; DIAGNOSTIC INDICATORS; KNEE OSTEOARTHRITIS;
   INSULIN-RESISTANCE
AB Turmeric (Curcuma longa) is an important condiment used in the culinary of several countries to spice and give a more intense yellow color to food. The importance of this root has gained more attention due to the presence of bioactive compounds known as curcuminoids (the main class of phenolic compounds found in turmeric). The health benefits attributed to curcuminoids are mainly linked to curcumin, the major compound among curcuminoids. Scientific evidence from pre-clinical and clinical trials indicate that turmeric extracts (rich in curcumin) and curcumin can effectively improve the status of subjects by reducing the risk of cardiovascular diseases and diabetes as well as assisting in the management of illness. The present review aims to highlight the use of green extraction technologies to obtain curcuminoid-rich extracts and the health benefits associated with the consumption of turmeric extracts and curcumin (as dietary supplements) against cardiovascular diseases, diabetes, metabolic syndrome, arthritis, and mental disorders at clinical trial level. The current knowledge about the development of functional foods with curcumin is also discussed.
C1 [Munekata, Paulo E. S.; Pateiro, Mirian; Dominguez, Ruben; Lorenzo, Jose M.] Ctr Tecnol Carne Galicia, Rua Galicia 4,Parque Tecnol Galicia, San Cibrao Das Vinas 32900, Ourense, Spain.
   [Zhang, Wangang; Xing, Lujuan] Nanjing Agr Univ, Coll Food Sci & Technol, Jiangsu Collaborat Innovat Ctr Meat Prod & Proc, Key Lab Meat Proc & Qual Control,Minist Educ Chin, Nanjing 210095, Peoples R China.
   [Fierro, Elena Movilla] Complejo Hosp Univ Ourense, Orense, Spain.
   [Lorenzo, Jose M.] Univ Vigo, Fac Ciencias Ourense, Area Tecnol Alimentos, Orense 32004, Spain.
C3 Nanjing Agricultural University; Complexo Hospitalario Universitario de
   Ourense, Verin e O Barco de Valdeorras; Universidade de Vigo
RP Lorenzo, JM (corresponding author), Ctr Tecnol Carne Galicia, Rua Galicia 4,Parque Tecnol Galicia, San Cibrao Das Vinas 32900, Ourense, Spain.
EM jmlorenzo@ceteca.net
RI Munekata, Paulo/E-5608-2019; Pateiro, Mirian/AGF-8365-2022; Lorenzo
   Rodriguez, Jose Manuel/K-6375-2014; Dominguez-Valencia,
   Ruben/K-5793-2017
OI Lorenzo Rodriguez, Jose Manuel/0000-0002-7725-9294; Dominguez-Valencia,
   Ruben/0000-0002-2764-504X
FU GAIN (Axencia Galega de Innovacion) [IN607A2019/01]; Ministry of Economy
   and Competitiveness (MINECO, Spain) "Juan de la Cierva" program
   [FJCI-2016-29486]
FX Thanks to GAIN (Axencia Galega de Innovacion) for supporting this study
   (grant number IN607A2019/01). Paulo E. S. Munekata acknowledges
   postdoctoral fellowship support from the Ministry of Economy and
   Competitiveness (MINECO, Spain) "Juan de la Cierva" program
   (FJCI-2016-29486).
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NR 113
TC 54
Z9 55
U1 7
U2 42
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1756-4646
EI 2214-9414
J9 J FUNCT FOODS
JI J. Funct. Food.
PD APR
PY 2021
VL 79
AR 104392
DI 10.1016/j.jff.2021.104392
EA FEB 2021
PG 12
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA RO9TD
UT WOS:000641380600004
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Whaley-Connell, A
   Johnson, MS
   Sowers, JR
AF Whaley-Connell, Adam
   Johnson, Megan S.
   Sowers, James R.
TI Aldosterone: Role in the Cardiometabolic Syndrome and Resistant
   Hypertension
SO PROGRESS IN CARDIOVASCULAR DISEASES
LA English
DT Review
DE Aldosterone; Insulin resistance; Hypertension; Cardiometabolic syndrome
ID MINERALOCORTICOID RECEPTOR BLOCKADE; TO-RENIN RATIO; METABOLIC SYNDROME;
   GENE-EXPRESSION; PRIMARY HYPERALDOSTERONISM; INSULIN SENSITIVITY;
   PLASMA-ALDOSTERONE; OXIDATIVE STRESS; SKELETAL-MUSCLE; NA+/H+ EXCHANGE
C1 [Whaley-Connell, Adam; Johnson, Megan S.; Sowers, James R.] Univ Missouri Columbia, Sch Med, Dept Internal Med, Columbia, MO 65212 USA.
   [Sowers, James R.] Univ Missouri Columbia, Sch Med, Dept Med Pharmacol & Physiol, Columbia, MO 65212 USA.
   [Whaley-Connell, Adam; Sowers, James R.] Univ Missouri Columbia, Sch Med, Diabet & Cardiovasc Ctr Excellence, Columbia, MO 65212 USA.
   [Whaley-Connell, Adam; Sowers, James R.] Univ Missouri Columbia, Sch Med, Harry S Truman VA Med Ctr, Columbia, MO 65212 USA.
C3 University of Missouri System; University of Missouri Columbia;
   University of Missouri System; University of Missouri Columbia;
   University of Missouri System; University of Missouri Columbia;
   University of Missouri System; University of Missouri Columbia; US
   Department of Veterans Affairs; Veterans Health Administration (VHA);
   Harry S. Truman Memorial Veterans' Hospital
RP Sowers, JR (corresponding author), MU Diabet & Cardiovasc Ctr, HSC Diabet Ctr D109, 1 Hosp Dr, Columbia, MO 65212 USA.
EM sowersj@health.missouri.edu
OI Whaley-Connell, Adam/0000-0001-8955-5560
FU National Institutes of Health [R01 HL73101-01A1 NIH/NHLBI]; Veterans
   Affairs Research Service; Veterans Affairs Research Service [CDA-2]
FX National Institutes of Health(R01 HL73101-01A1 NIH/NHLBI) and the
   Veterans Affairs Research Service (VA Merit Review) support Dr Sowers'
   research. Dr Whaley-Connell is supported by the Veterans Affairs
   Research Service (CDA-2).
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NR 76
TC 102
Z9 110
U1 0
U2 11
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0033-0620
EI 1873-1740
J9 PROG CARDIOVASC DIS
JI Prog. Cardiovasc. Dis.
PD MAR-APR
PY 2010
VL 52
IS 5
BP 401
EP 409
DI 10.1016/j.pcad.2009.12.004
PG 9
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 574JH
UT WOS:000275984700004
PM 20226958
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Jahandideh, F
   Chakrabarti, S
   Davidge, ST
   Wu, JP
AF Jahandideh, Forough
   Chakrabarti, Subhadeep
   Davidge, Sandra T.
   Wu, Jianping
TI Egg white hydrolysate shows insulin mimetic and sensitizing effects in
   3T3-F442A pre-adipocytes
SO PLOS ONE
LA English
DT Article
ID CONVERTING ENZYME-INHIBITION; RENIN-ANGIOTENSIN SYSTEM; ACTIVATED
   RECEPTOR PPAR; METABOLIC SYNDROME; ADIPOSE-TISSUE; BLOOD-PRESSURE; COX-2
   EXPRESSION; TNF-ALPHA; ARTERIAL-HYPERTENSION; BIOACTIVE PEPTIDES
AB Insulin resistance and inflammation in adipose tissue is a key mechanism underlying metabolic syndrome, a growing health problem characterized by diabetes, obesity and hypertension. Previous work from our research group has demonstrated the potential of egg white ovotransferrin derived bioactive peptides against hypertension, oxidative stress and inflammation in vitro and in vivo. Egg white hydrolysate (EWH) has also shown anti-hypertensive effects in spontaneously hypertensive rats. Given the interplay among hypertension, inflammation, oxidative stress and metabolic syndrome, the objective of the study was to test the EWH on differentiation, insulin signaling and inflammatory responses in 3T3-F442A pre-adipocytes. Our study suggested that EWH could promote adipocyte differentiation as shown by increased lipid accumulation, increased release of adiponectin and upregulation of peroxisome proliferator associated receptor gamma (PPAR.) and CCAAT/enhancer binding protein alpha (C/EBP-a). In addition to enhanced insulin effects on the upregulation of protein kinase B/Akt phosphorylation, EWH treatment increased extracellular signal regulated kinase 1/2 (ERK1/2) phosphorylation to a level similar to that of insulin, indicating insulin sensitizing and mimetic properties of the EWH. EWH further attenuated cytokine induced inflammatory marker; cyclooxygenase -2 (COX-2) by 48.78%, possibly through the AP-1 pathway by down regulating c-Jun phosphorylation in adipocytes. Given the critical role of adipose in the pathogenesis of insulin resistance and metabolic syndrome, EWH may have potential applications in the prevention and management of metabolic syndrome and its complications.
C1 [Jahandideh, Forough; Chakrabarti, Subhadeep; Wu, Jianping] Univ Alberta, Dept Agr Food & Nutr Sci, Edmonton, AB, Canada.
   [Jahandideh, Forough; Chakrabarti, Subhadeep; Davidge, Sandra T.; Wu, Jianping] Univ Alberta, Cardiovasc Res Ctr, Edmonton, AB, Canada.
   [Davidge, Sandra T.] Univ Alberta, Dept Obstet & Gynecol, Edmonton, AB, Canada.
   [Davidge, Sandra T.] Univ Alberta, Dept Physiol, Edmonton, AB, Canada.
   [Davidge, Sandra T.] Univ Alberta, Women & Childrens Hlth Res Inst, Edmonton, AB, Canada.
C3 University of Alberta; University of Alberta; University of Alberta;
   University of Alberta; University of Alberta
RP Wu, JP (corresponding author), Univ Alberta, Dept Agr Food & Nutr Sci, Edmonton, AB, Canada.; Wu, JP (corresponding author), Univ Alberta, Cardiovasc Res Ctr, Edmonton, AB, Canada.
EM jwu3@ualberta.ca
RI Chakrabarti, Subhadeep/AAD-1078-2022; Wu, Jianping/H-9150-2012;
   Jahandideh, Forough/M-4648-2019
OI Jahandideh, Forough/0000-0001-9731-0854; Davidge,
   Sandra/0000-0002-5559-4905; Wu, Jianping/0000-0003-2574-5191
FU Alberta Livestock and Meat Agency (ALMA); Egg Farmers of Canada; Natural
   Sciences and Engineering Research Council (NSERC)
FX This work was supported by grants from Alberta Livestock and Meat Agency
   (ALMA), Egg Farmers of Canada, Egg Farmers of Alberta, and the Natural
   Sciences and Engineering Research Council (NSERC) to JW. The funders had
   no role in study design, data collection and analysis, decision to
   publish, or preparation of the manuscript.
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NR 80
TC 36
Z9 36
U1 1
U2 16
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD OCT 3
PY 2017
VL 12
IS 10
AR e0185653
DI 10.1371/journal.pone.0185653
PG 20
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA FI6UJ
UT WOS:000412131900035
PM 28972997
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Castro-Diehl, C
   Roux, AVD
   Seeman, T
   Shea, S
   Shrager, S
   Tadros, S
AF Castro-Diehl, Cecilia
   Roux, Ana V. Diez
   Seeman, Teresa
   Shea, Steven
   Shrager, Sandi
   Tadros, Sameh
TI Associations of socioeconomic and psychosocial factors with urinary
   measures of cortisol and catecholamines in the Multi-Ethnic Study of
   Atherosclerosis (MESA)
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE Urinary cortisol; Urinary catecholamines; Social factors; Psychological
   factors; Race/ethnicity; Multi-Ethnic of Atherosclerosis
ID CORONARY-HEART-DISEASE; CUMULATIVE BIOLOGICAL RISK; PITUITARY-ADRENAL
   AXIS; YOUNG-ADULTS CARDIA; MIDDLE-AGED WOMEN; CARDIOVASCULAR-DISEASE;
   DEPRESSIVE SYMPTOMS; PHYSIOLOGICAL DYSREGULATION; NOREPINEPHRINE
   EXCRETION; METABOLIC SYNDROME
AB Background: Stress hormones have been hypothesized to contribute to the social patterning of cardiovascular disease but evidence of differences in hormone levels across social groups is scant.
   Purpose: To examine the associations of socioeconomic and psychosocial factors with urinary levels of cortisol and catecholamines and determine whether these associations are modified by race/ethnicity.
   Methods: Measures of cortisol, epinephrine, norepinephrine and dopamine were obtained on 12-h overnight urine specimens from 942 White, African American and Hispanic participants in the Multi-Ethnic Study of Atherosclerosis (MESA). Linear regression was used to examine associations of income-wealth index, education, depression, anger, anxiety and chronic stress with the four hormones after adjustment for covariates.
   Results: Higher income-wealth index was associated with lower levels of urinary cortisol, epinephrine, norepinephrine and dopamine, after adjustment for age, sex, race/ethnicity, medication use, body mass index, smoking, and alcohol use. Education and psychosocial factors were not associated with urinary stress hormone levels in the full sample. However, there was some evidence of effect modification by race: SES factors were more strongly inversely associated with cortisol in African Americans than in other groups and anger was inversely associated with catecholamines in African Americans but not in the other groups.
   Conclusions: Lower SES as measured by income-wealth index in a multi-ethnic sample is associated with higher levels of urinary cortisol and catecholamines. Heterogeneity in these associations by race/ethnicity warrants further exploration. (c) 2013 Elsevier Ltd. All rights reserved.
C1 [Castro-Diehl, Cecilia; Shea, Steven] Columbia Univ, Coll Physicians Surg, Dept Med, New York, NY 10032 USA.
   [Castro-Diehl, Cecilia; Shea, Steven] Columbia Univ, Mailman Sch Publ Hlth, Dept Epidemiol, New York, NY 10032 USA.
   [Roux, Ana V. Diez] Ctr Social Epidemiol & Populat Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA.
   [Seeman, Teresa] Univ Calif Los Angeles, Dept Med Geriatr, Los Angeles, CA 90095 USA.
   [Shrager, Sandi] Univ Washington, Dept Biostat, Seattle, WA 98115 USA.
   [Tadros, Sameh] Univ Calif, UCLA Res Ctr, Alhambra, CA 91801 USA.
C3 Columbia University; Columbia University; University of California
   System; University of California Los Angeles; University of Washington;
   University of Washington Seattle
RP Castro-Diehl, C (corresponding author), Columbia Univ, Med Ctr, 630 West 168th St,PH9 105, New York, NY 10027 USA.
EM oc83@cumc.columbia.edu
FU National Heart, Lung, and Blood Institute (NHLBI) [N01-HC-95159,
   N01-HC-95165, N01-HC-95169]; GCRC grant [UL1 TR000040];  [R01 HL076831]
FX This work was supported by R01 HL076831 (PI: Ana V. Diez Roux). MESA was
   supported by contracts N01-HC-95159 through N01-HC-95165 and
   N01-HC-95169 from the National Heart, Lung, and Blood Institute (NHLBI),
   and by GCRC grant UL1 TR000040 (formerly UL1 RR024156). NHLBI and GCRC
   had no further role in the study design; in the collection, analysis and
   interpretation of data; in the writing of the report; and in the
   decision to submit this paper for publication.
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NR 58
TC 35
Z9 37
U1 0
U2 16
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD MAR
PY 2014
VL 41
BP 132
EP 141
DI 10.1016/j.psyneuen.2013.12.013
PG 10
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA AB8PR
UT WOS:000332053000012
PM 24495614
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Agnese, ER
   Tariche, N
   Sharma, A
   Gulati, R
AF Agnese, Erica R.
   Tariche, Nicole
   Sharma, Amit
   Gulati, Raj
TI The Pathogenesis and Treatment of Hidradenitis Suppurativa
SO CUREUS JOURNAL OF MEDICAL SCIENCE
LA English
DT Review
DE multimodal intervention; hidradenitis suppurativa risk factors;
   hidradenitis suppurativa; hidradenitis suppurativa treatment;
   hidradenitis suppurativa pathogenesis
AB Hidradenitis suppurativa (HS) is a multifactorial disease involving the skin and subcutaneous tissues characterized by deep-seated, painful nodules and abscesses with draining sinus tracts. It affects mostly younger individuals between the ages of 18 and 34. The discomfort and embarrassment that patients affected by HS experience negatively impact their daily lives. It is associated with decreased quality of life and high rates of comorbid depression and anxiety. The rate of depression in HS was reported to be as high as 26%. Its pathogenesis is multifactorial and as such requires a multimodal approach to treatment, which subsequently is reviewed here. Moreover, the pathogenesis of HS is complex and only partially understood. Autoinflammation is the key driver of disease development and is linked with dysregulated inflammasome activation with the subsequent production of inflammatory cytokines. Genetics and cutaneous microbiome play a role in the development of chronic inflammation and lesion formation. Risk factors such as obesity, metabolic syndrome, diabetes, and smoking also add to the systemic inflammation. Targeting these risk factors is a key aspect of the treatment of HS. Lifestyle modifications are used in conjunction with pharmacotherapy and procedures to effectively manage the disease.
C1 [Agnese, Erica R.; Sharma, Amit] Lake Erie Coll Osteopath Med, Dermatol, Elmira, NY 14901 USA.
   [Tariche, Nicole] Lake Erie Coll Osteopath Med, Obstet & Gynecol, Elmira, NY USA.
   [Gulati, Raj] Lake Erie Coll Osteopath Med, Gen Surg, Elmira, NY USA.
RP Agnese, ER (corresponding author), Lake Erie Coll Osteopath Med, Dermatol, Elmira, NY 14901 USA.
EM eagnese06754@med.lecom.edu
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NR 32
TC 6
Z9 6
U1 0
U2 0
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
EI 2168-8184
J9 CUREUS J MED SCIENCE
JI Cureus J Med Sci
PD NOV 25
PY 2023
VL 15
IS 11
AR e49390
DI 10.7759/cureus.49390
PG 9
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA Z9YO9
UT WOS:001115563800036
PM 38146560
OA gold, Green Accepted
DA 2025-06-11
ER

PT J
AU Dolab, N
   Kamkar, MZ
   Amiriani, T
   Yuzugulen, J
   Marjani, M
   Marjani, A
AF Dolab, Neda
   Kamkar, Mohammad Zaman
   Amiriani, Taghi
   Yuzugulen, Jale
   Marjani, Majid
   Marjani, Abdoljalal
TI The association between leptin and adiponectin, and metabolic syndrome
   components and serum levels of lipid peroxidation in bipolar disorder
   patients treated with lithium and valproic acid
SO HELIYON
LA English
DT Article
DE Public health; Clinical genetics; Internal medicine; Laboratory
   medicine; Clinical research; Leptin; Adiponectin; Metabolic syndrome
   components; Lipid peroxidation; Bipolar disorder patients; Lithium and
   valproic acid
ID INSULIN-RESISTANCE; CHOLESTEROL LEVELS; OXIDATIVE STRESS; PLASMA LEPTIN;
   OBESITY; ADIPOKINES; DYSFUNCTION; OVERWEIGHT; OUTCOMES; FOCUS
AB Background: The aim of study is to assess a relation between the adiponectin and leptin levels, and metabolic syndrome components and lipid peroxidation treated with Li and VPA in bipolar disorder patients and compared with controls.
   Materials and methods: 56 patients and 31 healthy controls were enrolled. The ATP III criteria were used to determine metabolic syndrome components. Leptin, adiponectin, lipid peroxidation and lipid profiles were measured.
   Results: Malondialdehyde in Li patients was higher than VPA patients. BMI, waist circumference (WC), triglyceride, malondialdehyde and adiponectin levels were increased, whereas HDL-cholesterol (VPA treated patients) and leptin were decreased in patients compared with controls. Leptin and adiponectin were correlated with WC, triglyceride and malondialdehyde in both groups. Adiponectin was correlated with HDL-cholesterol in VPA patients.
   Conclusion: Patients should be checked metabolic syndrome components, serum leptin and adiponectin level occasionally to prevent possible deficiency or pathologic increase of these parameters.
C1 [Dolab, Neda] Golestan Univ Med Sci, Gorgan Fac Med, Metab Disorders Res Ctr, Dept Biochem & Biophys,Student Res Comm, Gorgan, Golestan, Iran.
   [Kamkar, Mohammad Zaman] Golestan Univ Med Sci, Golestan Res Ctr Psychiat, Dept Psychiat, Gorgan, Golestan, Iran.
   [Amiriani, Taghi] Golestan Univ Med Sci, Golestan Res Ctr Gastroenterol & Hepatol, Gorgan, Golestan, Iran.
   [Yuzugulen, Jale; Marjani, Majid] Eastern Mediterranean Univ, Fac Pharm, Mersin 10, Famagusta, North Cyprus, Turkey.
   [Marjani, Abdoljalal] Golestan Univ Med Sci, Fac Med, Metab Disorders Res Ctr, Dept Biochem & Biophys, Gorgan, Golestan, Iran.
C3 Golestan University of Medical Sciences; Golestan University of Medical
   Sciences; Golestan University of Medical Sciences; Eastern Mediterranean
   University; Golestan University of Medical Sciences
RP Marjani, M (corresponding author), Eastern Mediterranean Univ, Fac Pharm, Mersin 10, Famagusta, North Cyprus, Turkey.; Marjani, A (corresponding author), Golestan Univ Med Sci, Fac Med, Metab Disorders Res Ctr, Dept Biochem & Biophys, Gorgan, Golestan, Iran.
EM majidmarjani1379@gmail.com; abdoljalal@yahoo.com
RI Amiriani, Taghi/AAT-7496-2020; kamkar, mohammad/S-8140-2016; Marjani,
   Abdol/P-8976-2017
OI YUZUGULEN, JALE/0000-0001-6833-0637
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NR 66
TC 6
Z9 6
U1 0
U2 1
PU CELL PRESS
PI CAMBRIDGE
PA 50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA
EI 2405-8440
J9 HELIYON
JI Heliyon
PD JUL
PY 2020
VL 6
IS 7
AR e04553
DI 10.1016/j.heliyon.2020.e04553
PG 7
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA MY9LB
UT WOS:000558740400012
PM 32760840
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Yazici, HU
   Poyraz, F
   Sen, N
   Tavil, Y
   Turfan, M
   Tulmaç, M
   Abaci, A
AF Yazici, Huseyin U.
   Poyraz, Fatih
   Sen, Nihat
   Tavil, Yusuf
   Turfan, Murat
   Tulmac, Murat
   Abaci, Adnan
TI Relationship between mean platelet volume and left ventricular systolic
   function in patients with metabolic syndrome and ST-elevation myocardial
   infarction
SO CLINICAL AND INVESTIGATIVE MEDICINE
LA English
DT Article
ID RISK-FACTOR; MORTALITY; COUNT; ASSOCIATION; INDEXES; DISEASE; SIZE
AB Purpose: Mean platelet volume (MPV) is an indicator of platelet activation, which is a central process in the pathophysiology of coronary heart disease. Metabolic syndrome (MS) may lead to worsened left ventricular systolic function by causing recurrent thrombotic events and by aggravating systemic inflammation in the course of acute myocardial infarction. The present study was designed to investigate the relationship between MPV and left ventricular systolic function in patients with metabolic syndrome who had first ST-elevation myocardial infarction.
   Methods: MPV was measured on admission in 33 patients who had preserved left ventricle systolic function (mean age, 56.9 +/- 10.2 years) and in 48 patients who had depressed left ventricle systolic function (mean age, 57.9 +/- 10.5 years) with metabolic syndrome and first ST elevation myocardial infarction. Depressed left ventricle systolic function was defined as <= 50%ejection fraction value. MPV levels were compared in the two groups.
   Results: MPV was significantly higher in patients with depressed left ventricle systolic function in comparison with patients showing preserved left ventricle systolic function (p=0.02). Logistic regression analysis showed an independent relationship between MPV and deteriorated left ventricular systolic function, even after adjustment for potential confounders (1.08 (1.04-1.20), CI: 95%, p=0.02).
   Conclusions: Increased MPV on admission can be associated with degree of left ventricle systolic depression in patients with metabolic syndrome with first ST-elevation myocardial infarction. MPV may prove to be useful as a prognostic marker in patients with metabolic syndrome and ST elevation MI.
C1 [Yazici, Huseyin U.; Poyraz, Fatih; Sen, Nihat; Tavil, Yusuf; Turfan, Murat; Tulmac, Murat; Abaci, Adnan] Gazi Univ, Dept Cardiol, Sch Med, Ankara, Turkey.
C3 Gazi University
RP Yazici, HU (corresponding author), Eskisehir Osmangazi Univ, Sch Med, Dept Cardiol, Eskisehir, Turkey.
EM drhyazici@gmail.com
RI Turfan, Murat/B-8972-2014; Poyraz, Fatih/JZD-3254-2024; Tulmac,
   Murat/JDU-2366-2023
OI Tulmac, Murat/0000-0001-7491-5447
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NR 31
TC 19
Z9 19
U1 0
U2 2
PU CANADIAN SOC CLINICAL INVESTIGATION
PI OTTAWA
PA 114 CHEYENNE WAY, OTTAWA, ON K2J 0E9, CANADA
SN 0147-958X
EI 1488-2353
J9 CLIN INVEST MED
JI Clin. Invest. Med.
PY 2011
VL 34
IS 6
BP E330
EP E335
PG 6
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 857OG
UT WOS:000297727400005
PM 22129921
DA 2025-06-11
ER

PT J
AU Castres, I
   Folope, V
   Dechelotte, P
   Tourny-Chollet, C
   Lemaitre, F
AF Castres, I.
   Folope, V.
   Dechelotte, P.
   Tourny-Chollet, C.
   Lemaitre, F.
TI Quality of Life and Obesity Class Relationships
SO INTERNATIONAL JOURNAL OF SPORTS MEDICINE
LA English
DT Article
DE obesity class; energy expenditure; health quality of life
ID BODY-MASS INDEX; ENERGY-EXPENDITURE; PERSONS SEEKING;
   PHYSICAL-ACTIVITIES; METABOLIC SYNDROME; MAJOR DEPRESSION; CHRONIC
   ILLNESS; WEIGHT-GAIN; EXERCISE; WOMEN
AB The aim of this study was to quantify the impact of obesity class on Health-Related Quality Of Life (HRQOL) and Total daily Energy Expenditure (TEE). 69 obese individuals were self-selected to 1 of 3 groups based upon Body Mass Index (BMI). Anthropometric parameters (height, weight, waist and hip circumference, fat mass, lean body mass), biological parameters (high density lipoprotein, low density lipoprotein, triglycerides, glycaemia, total cholesterol), and resting energy expenditure were assessed for each group. The Short Form Health Survey (SF-36) questionnaire and Hospital Anxiety Depression (HAD) scale were used to measure HRQOL, and TEE was estimated by Kurpad's method. Class 3 obesity was associated with greater impairment of the physical aspects of the SF-36 (37.2 +/- 11.3), greater depression risk (8.2 +/- 4.1), and higher TEE (30.0 +/- 7.9 Kcal.day(-1).kg(-1)) than the lower obesity classes. No difference was observed among the 3 groups in the mental and psychosocial aspects of HRQOL. Impaired physical functioning was correlated with fat mass, age, waist circumference, glycaemia control and bodily pain. TEE was positively correlated with BMI, weight, fat mass and lean body mass. The obesity class had a negative impact on the physical health aspect of HRQOL, depression risk and energy expenditure. These impairments were associated with excess fat mass, waist circumference and glycaemia parameters.
C1 [Castres, I.; Tourny-Chollet, C.; Lemaitre, F.] Fac Sci Sport, CETAPS, EA 3832, F-76130 Mont St Aignan, France.
   [Folope, V.; Dechelotte, P.] CHU Hop Rouen, Unite Nutr Clin, Rouen, France.
   [Folope, V.; Dechelotte, P.] CHU Hop Rouen, Grp Appareil Digestif Environm Nutr, ADEN, EA3234, Rouen, France.
C3 Universite de Rouen Normandie; Universite de Rouen Normandie; CHU de
   Rouen; Universite de Rouen Normandie; CHU de Rouen
RP Lemaitre, F (corresponding author), Fac Sci Sport, CETAPS, EA 3832, Blvd Siegfried, F-76130 Mont St Aignan, France.
EM frederic.lemaitre@univ-rouen.fr
RI tourny, claire/AAN-4859-2020; Lemaitre, Frederic/AAZ-4457-2020
OI Lemaitre, Frederic/0000-0003-4424-0981; tourny,
   claire/0000-0002-1951-7785; Castres, Ingrid/0009-0007-1150-190X
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NR 42
TC 29
Z9 38
U1 0
U2 11
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0172-4622
J9 INT J SPORTS MED
JI Int. J. Sports Med.
PD NOV
PY 2010
VL 31
IS 11
BP 773
EP 778
DI 10.1055/s-0030-1262830
PG 6
WC Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Sport Sciences
GA 675PN
UT WOS:000283842800003
PM 20677125
DA 2025-06-11
ER

PT J
AU Matsuura, N
   Nagasawa, K
   Minagawa, Y
   Ito, S
   Sano, Y
   Yamada, Y
   Hattori, T
   Watanabe, S
   Murohara, T
   Nagata, K
AF Matsuura, Natsumi
   Nagasawa, Kai
   Minagawa, Yuji
   Ito, Shogo
   Sano, Yusuke
   Yamada, Yuichiro
   Hattori, Takuya
   Watanabe, Shogo
   Murohara, Toyoaki
   Nagata, Kohzo
TI Restraint stress exacerbates cardiac and adipose tissue pathology via
   β-adrenergic signaling in rats with metabolic syndrome
SO AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
LA English
DT Article
DE metabolic syndrome; restraint stress; sympathetic nervous system;
   cardiac remodeling; adipose tissue
ID INSULIN-RESISTANCE; OXIDATIVE STRESS; HEART-FAILURE; ANIMAL-MODEL;
   DAHLS.Z-LEPR(FA)/LEPR(FA) RATS; NEUROPEPTIDE-Y; OBESITY; EXPRESSION;
   HYPERTROPHY; DYSFUNCTION
AB Restraint stress stimulates sympathetic nerve activity and can affect adiposity and metabolism. However, the effects of restraint stress on cardiovascular and metabolic disorders in metabolic syndrome (MetS) have remained unclear. We investigated the effects of chronic restraint stress and beta-adrenergic receptor (beta-AR) blockade on cardiac and adipose tissue pathology and metabolic disorders in a rat model of MetS. DahlS. Z-Lepr(fa)/Lepr(fa) (DS/obese) rats, derived from a cross between Dahl salt-sensitive and Zucker rats. Rats were exposed to restraint stress (restraint cage, 2 h/day) for 4 wk from 9 wk of age with or without daily subcutaneous administration of the beta-AR blocker propranolol (2 mg/kg). Age-matched homozygous lean littermates of DS/obese rats (DahlS. Z-Lepr(+)/Lepr(+) rats) served as control animals. Chronic restraint stress exacerbated hypertension as well as left ventricular hypertrophy, fibrosis, diastolic dysfunction, and oxidative stress in a manner sensitive to propranolol treatment. Restraint stress attenuated body weight gain in DS/obese rats, and this effect tended to be reversed by propranolol (P = 0.0682). Restraint stress or propranolol did not affect visceral or subcutaneous fat mass. However, restraint stress potentiated cardiac and visceral adipose tissue inflammation in DS/obese rats, and these effects were ameliorated by propranolol. Restraint stress also exacerbated glucose intolerance, insulin resistance, and abnormal lipid metabolism in a manner sensitive to propranolol. In addition, restraint stress increased urinary norepinephrine excretion, and propranolol attenuated this effect. Our results thus implicate beta-ARs in the exacerbation of cardiac and adipose tissue pathology and abnormal glucose and lipid metabolism induced by restraint stress in this model of MetS.
C1 [Matsuura, Natsumi; Nagasawa, Kai; Ito, Shogo; Sano, Yusuke; Yamada, Yuichiro; Hattori, Takuya; Watanabe, Shogo; Nagata, Kohzo] Nagoya Univ, Grad Sch Med, Dept Pathophysiol Lab Sci, Nagoya, Aichi 4618673, Japan.
   [Minagawa, Yuji] Nagoya Univ, Sch Hlth Sci, Dept Med Technol, Nagoya, Aichi 4618673, Japan.
   [Murohara, Toyoaki] Nagoya Univ, Grad Sch Med, Dept Cardiol, Nagoya, Aichi 4618673, Japan.
C3 Nagoya University; Nagoya University; Nagoya University
RP Nagata, K (corresponding author), Nagoya Univ, Grad Sch Med, Dept Pathophysiol Lab Sci, Higashi Ku, 1-1-20 Daikominami, Nagoya, Aichi 4618673, Japan.
EM nagata@met.nagoya-u.ac.jp
RI Murohara, Toyoaki/M-4958-2014
FU Ministry of Education, Culture, Sports, Science, and Technology of Japan
   [24590690]; Grants-in-Aid for Scientific Research [24590690] Funding
   Source: KAKEN
FX This work was supported by Ministry of Education, Culture, Sports,
   Science, and Technology of Japan Grant 24590690 (to K. Nagata).
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NR 52
TC 31
Z9 32
U1 0
U2 10
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0363-6135
EI 1522-1539
J9 AM J PHYSIOL-HEART C
JI Am. J. Physiol.-Heart Circul. Physiol.
PD MAY 15
PY 2015
VL 308
IS 10
BP H1275
EP H1286
DI 10.1152/ajpheart.00906.2014
PG 12
WC Cardiac & Cardiovascular Systems; Physiology; Peripheral Vascular
   Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Physiology
GA CI4IT
UT WOS:000354712600012
PM 25770247
DA 2025-06-11
ER

PT J
AU Koutra, K
   Vassilaki, M
   Georgiou, V
   Koutis, A
   Bitsios, P
   Kogevinas, M
   Chatzi, L
AF Koutra, K.
   Vassilaki, M.
   Georgiou, V.
   Koutis, A.
   Bitsios, P.
   Kogevinas, M.
   Chatzi, L.
TI Pregnancy, perinatal and postpartum complications as determinants of
   postpartum depression: the Rhea mother-child cohort in Crete, Greece
SO EPIDEMIOLOGY AND PSYCHIATRIC SCIENCES
LA English
DT Article
DE Perinatal; postpartum complications; postpartum depression; pregnancy
ID MATERNAL MENTAL-HEALTH; OBSTETRIC RISK-FACTORS; POSTNATAL DEPRESSION;
   METABOLIC SYNDROME; SLEEP; PREVALENCE; MOOD; SYMPTOMS; WOMEN;
   TRAJECTORIES
AB Aims. Few epidemiological studies evaluated associations between perinatal complications and maternal mood at the early postpartum period and the findings are inconsistent. We aimed at investigating a wide range of complications during pregnancy, at delivery, and at the early postpartum period as determinants of postpartum depression (PPD) at 8 weeks postpartum.
   Methods. A total of 1037 women who enrolled in the Rhea mother-child cohort in Crete, Greece participated in the present study. Information on pregnancy, perinatal and postpartum complications was obtained from clinical records or by questionnaires. Postpartum depressive symptoms were assessed at 8 weeks postpartum using the Edinburgh Postnatal Depression Scale (EPDS). Multivariable linear and logistic regression models were fit to estimate the association between pregnancy, perinatal and postpartum complications and maternal depressive symptoms, adjusting also for potential confounders.
   Results. The prevalence of women with probable depression (EPDS score >= 13) was 13.6% at 8 weeks postpartum. Gestational hypertension and/or preeclampsia (beta coefficient 1.86, 95% CI: 0.32, 3.41) and breastfeeding difficulties (beta coefficient 0.77, 95% CI: 0.02, 1.53) were significantly associated with higher PPD symptoms. Sleep patterns during pregnancy, such as sleep deprivation (OR = 3.57, 95% CI: 1.91, 6.67) and snoring (OR = 1.81, 95% CI: 1.11, 2.93), and breastfeeding duration less than 2 months (OR = 1.77, 95% CI: 1.19, 2.64) were significantly associated with increase in the odds for PPD. Some other complications, such as unplanned pregnancy and hospitalisation during pregnancy were also associated with EPDS score, but these associations were explained by socio-demographic characteristics of the mother.
   Conclusions. We found that several pregnancy, perinatal and postpartum complications may have an adverse effect on maternal mood at the early postpartum period. These findings have considerable implications for developing effective prevention and early psychoeducational intervention strategies for women at risk of developing PPD.
C1 [Koutra, K.; Georgiou, V.; Koutis, A.; Chatzi, L.] Univ Crete, Fac Med, Dept Social Med, POB 2208, Iraklion 71003, Crete, Greece.
   [Koutra, K.; Bitsios, P.] Univ Crete, Fac Med, Dept Psychiat & Behav Sci, Iraklion, Greece.
   [Vassilaki, M.] Mayo Clin, Dept Hlth Sci Res, Rochester, MN USA.
   [Kogevinas, M.] Natl Sch Publ Hlth, Athens, Greece.
   [Kogevinas, M.] Ctr Res Environm Epidemiol CREAL, Barcelona, Spain.
   [Kogevinas, M.] Municipal Inst Med Res, Barcelona, Spain.
   [Kogevinas, M.] CIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain.
C3 University of Crete; University of Crete; Mayo Clinic; National &
   Kapodistrian University of Athens; Pompeu Fabra University; Centre de
   Recerca en Epidemiologia Ambiental (CREAL); CIBER - Centro de
   Investigacion Biomedica en Red; CIBERESP
RP Koutra, K (corresponding author), Univ Crete, Fac Med, Dept Social Med, POB 2208, Iraklion 71003, Crete, Greece.
EM koutra.k@gmail.com
RI Kogevinas, Manolis/C-3918-2017
FU Greek Ministry of Health;  [EU FP6-003-Food-3-NewGeneris];  [16320]; 
   [36224];  [EU FP7 ENV.2007.1.2.2.2];  [211250 Escape];  [EU
   FP7-2008-ENV-1.2.1.4];  [226756];  [EU FP7-HEALTH-2009];  [241604];  [EU
   FP7 ENV.2008.1.2.1.6.];  [226285 ENRIECO];  [264357 MeDALL];  [308333
   HELIX]
FX The Rhea project was financially supported by European projects (EU
   FP6-003-Food-3-NewGeneris - Contract no. 16320, EU FP6 STREP Hiwate -
   Contract no. 36224, EU FP7 ENV.2007.1.2.2.2. - Project no. 211250
   Escape, EU FP7-2008-ENV-1.2.1.4 Envirogenomarkers - Contract no. 226756,
   EU FP7-HEALTH-2009-single stage CHICOS - Contract no. 241604, EU FP7
   ENV.2008.1.2.1.6. - Proposal no. 226285 ENRIECO, EU-FP7 - Proposal no.
   264357 MeDALL, EU-FP7-HEALTH-2012 - Proposal no. 308333 HELIX) and the
   Greek Ministry of Health (Program of Prevention of obesity and
   neurodevelopmental disorders in preschool children, in Heraklion
   district, Crete, Greece: 2011-2014; 'Rhea Plus': Prevention Program of
   Environmental Risk Factors for Reproductive Health, and Child Health:
   2012-2015).
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NR 62
TC 49
Z9 51
U1 0
U2 24
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 2045-7960
EI 2045-7979
J9 EPIDEMIOL PSYCH SCI
JI Epidemiol. Psychiatr. Sci.
PD JUN
PY 2018
VL 27
IS 3
BP 244
EP 255
DI 10.1017/S2045796016001062
PG 12
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA GE1YH
UT WOS:000431012200009
PM 28004625
OA Green Published
DA 2025-06-11
ER

PT J
AU Moon, JH
   Jung, S
AF Moon, Ji Hyun
   Jung, Sua
TI Trend of Metabolic Syndrome Indicators in Working Korean Women According
   to Smoking Status and Workplace Size: A Population-Based Retrospective
   Longitudinal Study
SO PUBLIC HEALTH NURSING
LA English
DT Review
DE metabolic syndrome; smoking; women; working women; workplace
ID LIFE-STYLE; CARDIOVASCULAR RISK; SELF-EFFICACY; HEALTH; INTERVENTIONS;
   MANAGEMENT; PROGRAM; PANEL
AB ObjectiveSmoking, a risk factor for metabolic syndrome, is associated with stress relief and pleasure among women, which can hinder efforts to quit smoking, particularly in workplaces. We investigated the metabolic syndrome indicators among working Korean women based on smoking status and workplace size to devise tailored smoking cessation policies.DesignRetrospective longitudinal study.SampleData from 53,126 working Korean women aged 15-64 years were collected between 2009 and 2015.MeasurementsData were collected from the Female Employees Database derived from the National Health Insurance Service. To assess the trend of metabolic syndrome indicators among working Korean women according to smoking status and workplace size, repeated-measures analysis of variance was used.ResultsSignificant interactions were found between time and group for waist circumference (WC), diastolic blood pressure (DBP), and fasting glucose (FG) levels. Trends of metabolic syndrome were more prevalent in small- and medium-sized enterprises (SMSEs) than in large-sized enterprises (LSEs). Current smokers in the LSE group had the highest WC, triglyceride, systolic blood pressure, and FG values.ConclusionsThese insights may be valuable for devising policies and interventions to improve metabolic health among women working in SMSEs and current smokers in LSEs.
C1 [Moon, Ji Hyun] Sangmyung Univ, Dept Nursing, Cheonan, Chungcheongnam, South Korea.
   [Jung, Sua] Nambu Univ, Dept Nursing, Gwangju, South Korea.
C3 Sangmyung University; Nambu University
RP Jung, S (corresponding author), Nambu Univ, Dept Nursing, Gwangju, South Korea.
EM sjung@nambu.ac.kr
OI Jung, Sua/0000-0001-9858-1314
FU Basic Science Research Program through the National Research Foundation
   of Korea funded by the Ministry of Education
FX We would like to thank all individuals who provided information for the
   Female Employees Database for the last 7 years. In addition, we are
   grateful to the field staff, relevant academic societies, and expert
   advisory groups for their support and advice.
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NR 61
TC 0
Z9 0
U1 2
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0737-1209
EI 1525-1446
J9 PUBLIC HEALTH NURS
JI Public Health Nurs.
PD MAR
PY 2025
VL 42
IS 2
BP 709
EP 722
DI 10.1111/phn.13510
EA DEC 2024
PG 14
WC Public, Environmental & Occupational Health; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; Nursing
GA Z8S3B
UT WOS:001377465700001
PM 39676030
OA hybrid
DA 2025-06-11
ER

PT J
AU Stanley, SH
   Laugharne, JDE
   Addis, S
   Sherwood, D
AF Stanley, Susanne H.
   Laugharne, Jonathan D. E.
   Addis, Stephen
   Sherwood, Diane
TI Assessing overweight and obesity across mental disorders: personality
   disorders at high risk
SO SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY
LA English
DT Article
DE Mental illness; Overweight; Obesity; Metabolic syndrome
ID METABOLIC SYNDROME; HEALTH; EPIDEMIOLOGY; QUALITY; ILLNESS; WEIGHT;
   PEOPLE; CARE
AB The aim of the present investigation is to assess the prevalence of obesity in people diagnosed as having a mental illness and to investigate differences between disorders. This adds to the paucity of research in this particular population of people and assists with preventative knowledge to obtain optimum physical health.
   Data were collected for all 508 male and female inpatients (new and already existing) in a public mental health service centre in Western Australia between January and December 2008. Current weight for all patients and weight gain for some patients were calculated to obtain a body mass index (BMI) value, and diagnostic information was aligned to one of the six major categories of mental illness.
   The percentage of obese inpatients (30.3 %) was much higher than that of the general population (21.4 %), with females showing a higher propensity toward obesity than males. Most diagnostic categories had a mean BMI in the overweight range, whereas Personality Disorders had a mean BMI in the obese range (30.07). A gradual increase in weight over a 9-month time period can be seen in most patients who were assessed on more than one occasion.
   The proportion of obese people within the mental health system far exceeds that of the general population, with these people at a much greater risk of becoming obese. The highest level of obesity was found in people with a personality disorder rather than in people with psychosis. Further research is needed to ease out the mitigating factors behind weight gain occurring across disorders.
C1 [Stanley, Susanne H.; Laugharne, Jonathan D. E.] Univ Western Australia, Fremantle Hosp, Sch Psychiat & Clin Neurosci, Commun Culture & Mental Hlth Unit, Fremantle, WA 6160, Australia.
   [Addis, Stephen; Sherwood, Diane] Fremantle Hosp, Fremantle Mental Hlth Serv, Fremantle, WA, Australia.
C3 University of Western Australia; South Metropolitan Health Service;
   Fiona Stanley Fremantle Hospitals Group; Fremantle Hospital; South
   Metropolitan Health Service; Fiona Stanley Fremantle Hospitals Group;
   Fremantle Hospital
RP Stanley, SH (corresponding author), Univ Western Australia, Fremantle Hosp, Sch Psychiat & Clin Neurosci, Commun Culture & Mental Hlth Unit, W Block,L6,1 Alma St, Fremantle, WA 6160, Australia.
EM Susanne.Stanley@uwa.edu.au
RI Stanley, Susanne/H-5882-2014
OI Stanley, Susanne/0000-0002-0404-9018
CR [Anonymous], WHO TECHN SUPP SER
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NR 33
TC 16
Z9 21
U1 0
U2 22
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0933-7954
EI 1433-9285
J9 SOC PSYCH PSYCH EPID
JI Soc. Psychiatry Psychiatr. Epidemiol.
PD MAR
PY 2013
VL 48
IS 3
BP 487
EP 492
DI 10.1007/s00127-012-0546-1
PG 6
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 087SN
UT WOS:000314783000014
PM 22760817
DA 2025-06-11
ER

PT J
AU Hopps, E
   Caimi, G
AF Hopps, E.
   Caimi, G.
TI Matrix metalloproteinases in metabolic syndrome
SO EUROPEAN JOURNAL OF INTERNAL MEDICINE
LA English
DT Review
DE Metabolic syndrome; Matrix metalloproteases; Cardiovascular risk
ID ADIPOSE-TISSUE DEVELOPMENT; RENIN-ANGIOTENSIN SYSTEM;
   CORONARY-ARTERY-DISEASE; ESSENTIAL-HYPERTENSION; OXIDATIVE STRESS;
   WEIGHT-LOSS; HYPERCHOLESTEROLEMIC PATIENTS; CARDIOVASCULAR-DISEASE;
   DIABETIC-RETINOPATHY; OBESE CHILDREN
AB Metabolic syndrome is commonly accompanied by an elevated cardiovascular risk with high morbidity and mortality. The alterations of the arterial vasculature begin with endothelial dysfunction and lead to micro- and macrovascular complications. The remodeling of the endothelial basal membrane, that promotes erosion and thrombosis, has a multifactorial pathogenesis that includes leukocyte activation, increased oxidative stress and also an altered matrix metalloproteinases (MMPs) expression. MMPs are endopeptidases which degrade extracellular matrix proteins, such as collagen, gelatins, fibronectin and laminin. They can be secreted by several cells within the vascular wall, but macrophages are determinant in the atherosclerotic plaques. Their activity is regulated by tissue inhibitors of MMP (TIMPs) and also by other molecules, such as plasmin. MMPs could be implicated in plaque instability predisposing to vascular complications. It has been demonstrated that an impaired MMP or TIMP expression is associated with higher risk of all-cause mortality. A large number of studies evaluated MMPs pattern in obesity, diabetes mellitus, arterial hypertension and dyslipidemia, all of which define metabolic syndrome according to several Consensus Statement (i.e. IDF, ATP III, AHA). However, few research have been carried out on subjects with metabolic syndrome. The evidences of an improvement in MMP/TIMP ratio with diet, exercise and medical therapy should encourage further investigations with the intent to contrast the atherosclerotic process and to reduce morbidity and mortality of this kind of patients. (C) 2011 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.
C1 [Hopps, E.; Caimi, G.] Univ Palermo, Dept Internal Med Cardiovasc & Nefrol Dis, I-90127 Palermo, Italy.
C3 University of Palermo
RP Hopps, E (corresponding author), Univ Palermo, Dept Internal & Specialist Med, Via Vespro 129, I-90127 Palermo, Italy.
EM euhopps@libero.it
OI Caimi, Gregorio/0000-0001-8964-255X
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NR 73
TC 74
Z9 75
U1 0
U2 9
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0953-6205
EI 1879-0828
J9 EUR J INTERN MED
JI Eur. J. Intern. Med.
PD MAR
PY 2012
VL 23
IS 2
BP 99
EP 104
DI 10.1016/j.ejim.2011.09.012
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 887TN
UT WOS:000299953400011
PM 22284236
DA 2025-06-11
ER

PT J
AU Miller, GE
   Lachman, ME
   Chen, E
   Gruenewald, TL
   Karlamangla, AS
   Seeman, TE
AF Miller, Gregory E.
   Lachman, Margie E.
   Chen, Edith
   Gruenewald, Tara L.
   Karlamangla, Arun S.
   Seeman, Teresa E.
TI Pathways to Resilience: Maternal Nurturance as a Buffer Against the
   Effects of Childhood Poverty on Metabolic Syndrome at Midlife
SO PSYCHOLOGICAL SCIENCE
LA English
DT Article
DE socioeconomic status; health; stress reactions; childhood development
ID SOCIOECONOMIC POSITION; BIRTH COHORT; SOCIAL-CLASS; ADULT; LIFE;
   MORTALITY; HEALTH; RISK; DISEASE; CIRCUMSTANCES
AB Children raised in families with low socioeconomic status (SES) go on to have high rates of chronic illness in adulthood. However, a sizable minority of low-SES children remain healthy across the life course, which raises questions about the factors associated with, and potentially responsible for, such resilience. Using a sample of 1,205 middle-aged Americans, we explored whether two characteristics-upward socioeconomic mobility and early parental nurturance-were associated with resilience to the health effects of childhood disadvantage. The primary outcome in our analyses was the presence of metabolic syndrome in adulthood. Results revealed that low childhood SES was associated with higher prevalence of metabolic syndrome at midlife, independently of traditional risk factors. Despite this pattern, half the participants raised in low-SES households were free of metabolic syndrome at midlife. Upward social mobility was not associated with resilience to metabolic syndrome. However, results were consistent with a buffering scenario, in which high levels of maternal nurturance offset the metabolic consequences of childhood disadvantage.
C1 [Miller, Gregory E.; Chen, Edith] Univ British Columbia, Dept Psychol, Vancouver, BC V6T 1Z4, Canada.
   [Lachman, Margie E.] Brandeis Univ, Dept Psychol, Waltham, MA 02254 USA.
   [Gruenewald, Tara L.; Karlamangla, Arun S.; Seeman, Teresa E.] Univ Calif Los Angeles, Dept Geriatr Med, Los Angeles, CA USA.
C3 University of British Columbia; Brandeis University; University of
   California System; University of California Los Angeles
RP Miller, GE (corresponding author), Univ British Columbia, Dept Psychol, 2136 W Mall Ave, Vancouver, BC V6T 1Z4, Canada.
EM gemiller@psych.ubc.ca
RI Gruenewald, Tara/KLE-3300-2024
OI Miller, Gregory/0000-0002-7217-1082; Lachman, Margie/0000-0003-3027-8735
FU NCATS NIH HHS [UL1 TR000124] Funding Source: Medline; NCRR NIH HHS [UL1
   RR033176] Funding Source: Medline; NIA NIH HHS [P01 AG020166, R01
   AG032271, R01 AG-032271, P01 AG-020166] Funding Source: Medline; NICHD
   NIH HHS [R01 HD-058502, R01 HD058502] Funding Source: Medline
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NR 40
TC 153
Z9 178
U1 1
U2 47
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0956-7976
J9 PSYCHOL SCI
JI Psychol. Sci.
PD DEC
PY 2011
VL 22
IS 12
BP 1591
EP 1599
DI 10.1177/0956797611419170
PG 9
WC Psychology, Multidisciplinary
WE Social Science Citation Index (SSCI)
SC Psychology
GA 901HJ
UT WOS:000300954700020
PM 22123777
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Siener, R
   Ehrhardt, C
   Bitterlich, N
   Metzner, C
AF Siener, Roswitha
   Ehrhardt, Christina
   Bitterlich, Norman
   Metzner, Christine
TI Effect of a fat spread enriched with medium-chain triacylglycerols and a
   special fatty acid-micronutrient combination on cardiometabolic risk
   factors in overweight patients with diabetes
SO NUTRITION & METABOLISM
LA English
DT Article
ID HYPERTRIGLYCERIDEMIC WAIST PHENOTYPE; ENERGY-EXPENDITURE; OXIDATIVE
   STRESS; BODY-FAT; TRIGLYCERIDES; INFLAMMATION; CHOLESTEROL; DISEASE;
   MARKERS; TISSUE
AB Background: Medium-chain triacylglycerols (MCT), omega-3 polyunsaturated fatty acids (n-3-PUFA) and micronutrients may be useful for weight and cardiometabolic risk management. However, studies analyzing the effect of a combination of both in individuals at increased cardiometabolic risk are lacking. Therefore, this randomized, controlled, double-blind study investigated the effect of a fat spread enriched with two different doses of MCT and a special long-chain fatty acid-micronutrient combination on cardiometabolic risk factors in overweight diabetic patients.
   Methods: Fifty-four patients received either a fat spread with 6 g/d MCT (MCT30%) or 1.2 g/d (MCT6%). Forty-three completed the study. Analysis was performed according to the median of MCT intake (supplemented and foodderived MCT). Clinical, anthropometric, blood, 24 h-urine parameters and dietary intake were assessed at baseline and after 12 weeks.
   Results: Total MCT intake > 7 g/d (MCT > 7 group) significantly reduced waist circumference (WC) by 1.81 +/- 2.69 cm, whereas <= 7 g/d MCT (MCT <= 7 group) increased WC by 0.32 +/- 3.03 cm (p = 0.027), which was supported by a change in waist-to-height ratio (WHtR) (p = 0.018). Fasting serum triglycerides (TG) increased in both groups over time due to dietary habits. In contrast, diabetic metabolic situation and urinary albumin excretion did not alter. Urinary pH differed significantly between groups after 12 weeks.
   Conclusion: An intake of > 7 g/d MCT reduced WC in overweight diabetics, whereas the increase in the intake of fatty acids may have worsened fasting TG. Therefore, the suitability of a fat for nutrient enrichment remains to be challenged, and further studies in low-fat matrices are desirable.
C1 [Ehrhardt, Christina; Metzner, Christine] Bonn Educ Assoc Dietet rA, Cologne, Germany.
   [Siener, Roswitha] Univ Bonn, Dept Urol, D-5300 Bonn, Germany.
   [Bitterlich, Norman] Med & Serv Ltd, Dept Biostat, Chemnitz, Germany.
   [Metzner, Christine] Rhein Westfal TH Aachen, Univ Hosp, Dept Internal Med 3, Aachen, Germany.
C3 University of Bonn; RWTH Aachen University; RWTH Aachen University
   Hospital
RP Metzner, C (corresponding author), Bonn Educ Assoc Dietet rA, Cologne, Germany.
EM christine.metzner@rwth-aachen.de
FU basis GmbH, Woerthsee, Germany
FX This study was supported by a research grant from basis GmbH, Woerthsee,
   Germany. The funder was neither involved in the study design,
   interpretation of data, nor in the content of the final manuscript. None
   of the authors has a conflict of interest for this manuscript others
   than that the study has been funded by basis GmbH, Woerthsee, Germany.
   Prof. Dr. Dr. Metzner was a consultant for basis GmbH, Woerthsee,
   Germany.
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NR 30
TC 5
Z9 5
U1 0
U2 6
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1743-7075
J9 NUTR METAB
JI Nutr. Metab.
PD APR 8
PY 2011
VL 8
AR 21
DI 10.1186/1743-7075-8-21
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 761MT
UT WOS:000290402800001
PM 21477296
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Ulambayar, B
   Ghanem, AS
   Kovács, N
   Trefán, L
   Móré, M
   Nagy, AC
AF Ulambayar, Battamir
   Ghanem, Amr Sayed
   Kovacs, Nora
   Trefan, Laszlo
   More, Marianna
   Nagy, Attila Csaba
TI Cardiovascular disease and risk factors in adults with diabetes mellitus
   in Hungary: a population-based study
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Article
DE diabetes mellitus; cardiovascular disease; diabetes complication;
   cardiovascular risk factors; European health interview survey
ID ALCOHOL-CONSUMPTION; MORTALITY; COMPLICATIONS; HOSPITALIZATION;
   HYPERGLYCEMIA; PEOPLE; IMPACT; ASSOCIATION; EDUCATION; SMOKING
AB IntroductionDiabetes mellitus (DM) and cardiovascular disease (CVD) such as acute myocardial infarction, stroke, and coronary artery disease are highly prevalent conditions that are responsible for significant morbidity and mortality, particularly in Hungary. The conditions are attributed to identical risk factors, and individuals with DM are primarily susceptible to cardiovascular complications, which are the leading causes of death and disability in patients with DM. The objective of this study was to estimate the prevalence of CVD in individuals with DM and to investigate the association between potential risk factors and the presence of CVD among individuals with DM in a population-based sample.MethodsThe study was based on data from three waves of the European Health Interview Surveys (EHIS) conducted in Hungary in 2009, 2014, and 2019.ResultsThe prevalence of CVD among patients with DM decreased during the study period and that socioeconomic factors, cardiometabolic risk factors including high blood pressure and high cholesterol, and depression are major contributors to CVD burden in patients with DM in Hungary.DiscussionOur findings suggest the importance of regular check-up for hypertension and hypercholesterolemia, better focus on socioeconomic status, as well as ongoing monitoring of mental health among patients with diabetes. Further research is needed to understand the potential causes behind the observed decrease in CVD prevalence.
C1 [Ulambayar, Battamir; Ghanem, Amr Sayed; Trefan, Laszlo; Nagy, Attila Csaba] Univ Debrecen, Inst Hlth Informat, Fac Hlth Sci, Dept Hlth Informat, H-4028 Debrecen, Hungary.
   [Kovacs, Nora] Univ Debrecen, Fac Med, Dept Publ Hlth & Epidemiol, Debrecen, Hungary.
   [More, Marianna] Univ Debrecen, Inst Social & Sociol Sci, Fac Hlth Sci, H-4400 Nyiregyhaza, Hungary.
   [Nagy, Attila Csaba] Univ Debrecen, Coordinating Ctr Epidemiol, Debrecen, Hungary.
C3 University of Debrecen; University of Debrecen; University of Debrecen;
   University of Debrecen
RP Nagy, AC (corresponding author), Univ Debrecen, Inst Hlth Informat, Fac Hlth Sci, Dept Hlth Informat, H-4028 Debrecen, Hungary.; Nagy, AC (corresponding author), Univ Debrecen, Coordinating Ctr Epidemiol, Debrecen, Hungary.
EM nagy.attila@sph.unideb.hu
RI Nagy, Attila/IAM-8645-2023
OI Ghanem, Amr/0009-0006-0593-0188
FU The authors declare that no financial support was received for the
   research, authorship, and/or publication of this article.
FX The authors declare that no financial support was received for the
   research, authorship, and/or publication of this article.
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NR 58
TC 6
Z9 6
U1 4
U2 24
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD SEP 14
PY 2023
VL 14
AR 1263365
DI 10.3389/fendo.2023.1263365
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA S7FV0
UT WOS:001072799000001
PM 37780630
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Gimeno, D
   Tabák, AG
   Ferrie, JE
   Shipley, MJ
   De Vogli, R
   Elovainio, M
   Vahtera, J
   Marmot, MG
   Kivimäki, M
AF Gimeno, David
   Tabak, Adam G.
   Ferrie, Jane E.
   Shipley, Martin J.
   De Vogli, Roberto
   Elovainio, Marko
   Vahtera, Jussi
   Marmot, Michael G.
   Kivimaki, Mika
TI Justice at work and metabolic syndrome: the Whitehall II study
SO OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
LA English
DT Article
ID CORONARY-HEART-DISEASE; ORGANIZATIONAL JUSTICE; SLEEPING PROBLEMS;
   SICKNESS ABSENCE; RISK-FACTORS; HEALTH; INJUSTICE; ASSOCIATION; STRESS;
   CAUSATION
AB Objectives Growing evidence shows that high levels of justice are beneficial for employee health, although biological mechanisms underlying this association are yet to be clarified. We aim to test whether high justice at work protects against metabolic syndrome.
   Methods A prospective cohort study of 20 civil service departments in London (the Whitehall II study) including 6123 male and female British civil servants aged 35-55 years without prevalent coronary heart disease at baseline (1985-1990). Perceived justice at work was determined by means of questionnaire on two occasions between 1985 and 1990. Follow-up for metabolic syndrome and its components occurring from 1990 to 2004 was based on clinical assessments on three occasions over more than 18 years.
   Results Cox proportional hazard models adjusted for age, ethnicity and employment grade showed that men who experienced a high level of justice at work had a lower risk of incident metabolic syndrome than employees with a low level of justice (HR 0.75; 95% CI 0.63 to 0.89). There was little evidence of an association between organisational justice and metabolic syndrome or its components in women (HR 0.88; 95% CI 0.67 to 1.17).
   Conclusions Our prospective findings provide evidence of an association between high levels of justice at work and the development of metabolic syndrome in men.
C1 [Gimeno, David; Tabak, Adam G.; Ferrie, Jane E.; Shipley, Martin J.; De Vogli, Roberto; Elovainio, Marko; Marmot, Michael G.; Kivimaki, Mika] UCL, Dept Epidemiol & Publ Hlth, Sch Med, London WC1E 6BT, England.
   [Gimeno, David] Univ Texas Houston, Hlth Sci Ctr, Sch Publ Hlth, Div Environm & Occupat Hlth Sci, Houston, TX USA.
   [Gimeno, David] Inst Work & Hlth, Toronto, ON, Canada.
   [Tabak, Adam G.] Semmelweis Univ, Fac Med, Dept Internal Med 1, Budapest, Hungary.
   [Elovainio, Marko] Natl Res & Dev Ctr Welf & Hlth STAKES, Helsinki, Finland.
   [Vahtera, Jussi; Kivimaki, Mika] Finnish Inst Occupat Hlth, Helsinki, Finland.
C3 University of London; University College London; UCL Medical School;
   University of Texas System; University of Texas Health Science Center
   Houston; University of Texas School Public Health; Institute for Work &
   Health; Semmelweis University; Finland National Institute for Health &
   Welfare; Finnish Institute of Occupational Health
RP Gimeno, D (corresponding author), UCL, Dept Epidemiol & Publ Hlth, Sch Med, 1-19 Torrington Pl, London WC1E 6BT, England.
EM d.gimeno@ucl.ac.uk
RI Tabak, Adam/A-5007-2012; Vahtera, Jussi/J-3271-2013; Kivimaki,
   Mika/B-3607-2012; Ferrie, Jane/AAZ-2009-2020; Marmot,
   Michael/Y-3920-2019
OI Gimeno, David/0000-0003-2502-0465; Kivimaki, Mika/0000-0002-4699-5627;
   Vahtera, Jussi/0000-0002-6036-061X; Tabak, Adam/0000-0002-6234-3936;
   Elovainio, Marko/0000-0002-1401-1910; Marmot,
   Michael/0000-0002-2431-6419
FU Medical Research Council (MRC); Economic and Social Research Council;
   British Heart Foundation (BHF); Health and Safety Executive; Department
   of Health; National Heart Lung and Blood Institute, US, NIH [HL36310];
   National Institute on Ageing, US, NIH [AG13196]; Agency for Health Care
   Policy Research [HS06516]; John D and Catherine T MacArthur Foundation
   Research Network; NIA [AG13196]; MR [G8802774]; Academy of Finland
   [117604, 124271, 124322, 129262]; BHF; MRC [G0902037] Funding Source:
   UKRI
FX The Whitehall II study was supported by grants from the Medical Research
   Council (MRC); Economic and Social Research Council; British Heart
   Foundation (BHF); Health and Safety Executive; Department of Health;
   National Heart Lung and Blood Institute (HL36310), US, NIH; National
   Institute on Ageing (AG13196), US, NIH; Agency for Health Care Policy
   Research (HS06516); and the John D and Catherine T MacArthur Foundation
   Research Network on Successful Midlife Development and Socioeconomic
   Status and Health. DG and RDV are supported by the NIA (grant AG13196);
   JEF by the MRC (grant G8802774); MK, ME and JV by the Academy of Finland
   (grants 117604, 124271, 124322 and 129262); MJS by the BHF; and MGM is
   supported by an MRC research professorship.
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NR 38
TC 37
Z9 39
U1 0
U2 13
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 1351-0711
EI 1470-7926
J9 OCCUP ENVIRON MED
JI Occup. Environ. Med.
PD APR
PY 2010
VL 67
IS 4
BP 256
EP 262
DI 10.1136/oem.2009.047324
PG 7
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA 577CC
UT WOS:000276197500011
PM 19819861
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Cocoman, AM
   Gallagher, D
AF Cocoman, Angela M.
   Gallagher, Darren
TI A Retrospective Chart Review of Screening on the Prevalence of Metabolic
   Syndrome (MetS) in an Irish Community Mental Health Service
SO ISSUES IN MENTAL HEALTH NURSING
LA English
DT Review
ID CARDIOVASCULAR RISK-FACTORS; BODY-MASS INDEX; OBESITY; SCHIZOPHRENIA;
   PEOPLE; ILLNESS; METAANALYSIS; SMOKING; DISEASE; ABNORMALITIES
AB Individuals who are treated with antipsychotic medications are at risk of developing metabolic syndrome (MetS). The comorbidity of a severe mental illness (SMI) and a physical illness has a major impact on the quality of life of these individuals. We conducted a retrospective chart review (RCR) of 214 individuals with a diagnosis of schizophrenia who had been receiving antipsychotic medications for at least 6 months, in five clinical settings in an Irish community mental health service. The aim was to determine the presence of MetS to assist in improving screening practices and directing future practice. The National Cholesterol Education Program High Blood Cholesterol Adult Treatment Panel 111 (NCEP ATP 111) metabolic diagnostic criteria were utilised to determine prevalence. After examining 214 charts we observed that waist circumference varied from 68 to 142 cm, elevated waist circumference over the recommended parameters was recorded in 145 charts. Forty-five percent (n = 98) had blood pressure (BP) readings over 130/85. The range for body mass index (BMI)'s varied from 16 to 54, BMIs over 25 was recorded in 44% (n = 95) of charts. Elevated triglycerides (TG) were recorded in 37% (n = 80) and 45% (n = 97) had reduced HDL-C levels. Elevated glucose levels were found in 25% (n = 54) of the charts examined. The chart review found an overall prevalence rate of 44% (n = 94) for this sample. Regular audit of screening data used for the presence of MetS in individuals with SMI is essential in the detection of physical comorbidities and to improving the quality of life and prevention of premature deaths.
C1 [Cocoman, Angela M.; Gallagher, Darren] Dublin City Univ, Sch Nursing & Human Sci, Fac Sci & Hlth, Collins Ave, Dublin 9, Ireland.
C3 Dublin City University
RP Cocoman, AM (corresponding author), Dublin City Univ, Sch Nursing & Human Sci, Fac Sci & Hlth, Collins Ave, Dublin 9, Ireland.
EM angela.cocoman@dcu.ie
RI Cocoman, Angela/V-9506-2019
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NR 59
TC 4
Z9 4
U1 0
U2 2
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 0161-2840
EI 1096-4673
J9 ISSUES MENT HEALTH N
JI Issues Ment. Health Nurs.
PD OCT 3
PY 2019
VL 40
IS 10
SI SI
BP 895
EP 901
DI 10.1080/01612840.2019.1609636
EA JUN 2019
PG 7
WC Nursing; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Psychiatry
GA JB3PZ
UT WOS:000476390800001
PM 31295053
DA 2025-06-11
ER

PT J
AU Panchal, SK
   Wanyonyi, S
   Brown, L
AF Panchal, Sunil K.
   Wanyonyi, Stephen
   Brown, Lindsay
TI Selenium, Vanadium, and Chromium as Micronutrients to Improve Metabolic
   Syndrome
SO CURRENT HYPERTENSION REPORTS
LA English
DT Review
DE Micronutrients; Chromium; Selenium; Vanadium; Metabolic syndrome
ID ELEVATED BLOOD-PRESSURE; IN-VIVO; INSULIN SENSITIVITY; OXIDATIVE STRESS;
   PHOSPHATASE-ACTIVITY; DIABETES-MELLITUS; DIETARY SELENIUM; SERUM
   SELENIUM; SMOOTH-MUSCLE; DOUBLE-BLIND
AB Trace metals play an important role in the proper functioning of carbohydrate and lipid metabolism. Some of the trace metals are thus essential for maintaining homeostasis, while deficiency of these trace metals can cause disorders with metabolic and physiological imbalances. This article concentrates on three trace metals ( selenium, vanadium, and chromium) that may play crucial roles in controlling blood glucose concentrations possibly through their insulin-mimetic effects. For these trace metals, the level of evidence available for their health effects as supplements is weak. Thus, their potential is not fully exploited for the target of metabolic syndrome, a constellation that increases the risk for cardiovascular disease and type 2 diabetes. Given that the prevalence of metabolic syndrome is increasing throughout the world, a simpler option of interventions with food supplemented with well-studied trace metals could serve as an answer to this problem. The oxidation state and coordination chemistry play crucial roles in defining the responses to these trace metals, so further research is warranted to understand fully their metabolic and cardiovascular effects in human metabolic syndrome.
C1 [Panchal, Sunil K.; Wanyonyi, Stephen; Brown, Lindsay] Univ Southern Queensland, Inst Agr & environm, Toowoomba, Qld 4350, Australia.
   [Brown, Lindsay] Univ Southern Queensland, Sch Hlth & Wellbeing, Toowoomba, Qld 4350, Australia.
C3 University of Southern Queensland; University of Southern Queensland
RP Panchal, SK (corresponding author), Univ Southern Queensland, Inst Agr & environm, Toowoomba, Qld 4350, Australia.
EM Sunil.Panchal@usq.edu.au; Stephen.Wanyonyi@usq.edu.au;
   Lindsay.Brown@usq.edu.au
OI Panchal, Sunil K/0000-0001-5464-3376; wanyonyi,
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NR 142
TC 86
Z9 90
U1 2
U2 52
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1522-6417
EI 1534-3111
J9 CURR HYPERTENS REP
JI Curr. Hypertens. Rep.
PD MAR
PY 2017
VL 19
IS 3
AR 10
DI 10.1007/s11906-017-0701-x
PG 11
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA EP4DW
UT WOS:000397331900001
PM 28197835
DA 2025-06-11
ER

PT J
AU Pringsheim, T
   Panagiotopoulos, C
   Davidson, J
   Ho, J
AF Pringsheim, Tamara
   Panagiotopoulos, Constadina
   Davidson, Jana
   Ho, Josephine
CA Canadian Alliance Monitoring Effec
TI Evidence-based recommendations for monitoring safety of
   second-generation antipsychotics in children and youth
SO PAEDIATRICS & CHILD HEALTH
LA English
DT Article
DE Antipsychotics; Children and adolescents; Drug safety; Extrapyramidal
   symptoms; Metabolic syndrome
ID CARDIOVASCULAR RISK; METABOLIC-SYNDROME; PROLACTIN LEVELS; CHILDHOOD;
   ADULTHOOD
AB BACKGROUND: The use of antipsychotics, especially second-generation antipsychotics (SGAs), for children with mental health disorders in Canada has increased dramatically over the past five years. These medications have the potential to cause major metabolic and neurological complications with chronic use.
   OBJECTIVE: To synthesize the evidence for specific metabolic and neurological side effects associated with the use of SGAs in children, and provide evidence-based recommendations for the monitoring of these side effects.
   METHODS: A systematic review of controlled clinical trials of SGAs involving children was performed. Recommendations for monitoring SGA safety were made according to a classification scheme based on the GRADE (Grading of Recommendations Assessment, Development and Evaluation) system. When there was inadequate evidence, recommendations were based on consensus and expert opinion. A multidisciplinary consensus group reviewed all relevant evidence and reached consensus on the recommendations.
   RESULTS: The present guidelines provide evidence-based recommendations for monitoring SGA safety. The strength of recommendations for specific physical examination manoeuvres and laboratory tests are provided for each SGA medication at specific time points.
   CONCLUSION: Multiple randomized controlled trials evaluated the efficacy of many of the SGAs in paediatric mental health disorders. These benefits, however, are not without risks - both metabolic and neurological side effects occur in children treated with SGAs. The risk of weight gain, increased body mass index and abnormal lipid levels is greatest with olanzapine, followed by clozapine and quetiapine. The risk of neurological side effects of the treatment is greatest with risperidone, olanzapine and aripiprazole. Appropriate monitoring procedures for adverse effects will improve the quality of care of children treated with these medications.
C1 [Pringsheim, Tamara] Univ Calgary, Dept Clin Neurosci & Pediat, Calgary, AB T3B 6A8, Canada.
   [Panagiotopoulos, Constadina] Univ British Columbia, Dept Pediat, Vancouver, BC V6T 1W5, Canada.
   [Davidson, Jana] Univ British Columbia, Dept Psychiat, Vancouver, BC, Canada.
   [Ho, Josephine] Univ Calgary, Dept Pediat, Calgary, AB T3B 6A8, Canada.
C3 University of Calgary; University of British Columbia; University of
   British Columbia; University of Calgary
RP Pringsheim, T (corresponding author), Univ Calgary, Alberta Childrens Hosp, Dept Clin Neurosci & Pediat, C4-431,2888 Shaganappi Trail NW, Calgary, AB T3B 6A8, Canada.
EM tmprings@ucalgary.ca
RI Panagiotopoulos, Constadina/AAO-6827-2020; Pringsheim,
   Tamara/L-5955-2019; Patten, Scott/B-4434-2011
OI Patten, Scott/0000-0001-9871-4041; Panagiotopoulos,
   Constadina/0000-0002-1379-7472
FU Canadian Institutes of Health Research; Child AMP; Family Research
   Institute; Canadian Diabetes Association
FX The Canadian Alliance for Monitoring Effectiveness and Safety of
   Antipsychotics in Children (CAMESA) guideline project was funded by the
   Canadian Institutes of Health Research. Dr Panagiotopoulos receives
   Clinician Scientist salary support from the Child & Family Research
   Institute and the Canadian Diabetes Association.
CR Amer Diabet Assoc, 2004, DIABETES CARE, V27, P596, DOI 10.2337/diacare.27.2.596
   Anderson GM, 2007, BIOL PSYCHIAT, V61, P545, DOI 10.1016/j.biopsych.2006.02.032
   [Anonymous], 2008, BMJ, V336, p7650 : 924 926
   AstraZeneca, 2008, SER, P1
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   Blair J, 2004, J NEURAL TRANSM, V111, P791, DOI 10.1007/s00702-004-0153-8
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NR 20
TC 86
Z9 86
U1 0
U2 8
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1205-7088
EI 1918-1485
J9 PAED CHILD HEALT-CAN
JI Paediatr. Child Health
PD NOV
PY 2011
VL 16
IS 9
BP 581
EP 589
DI 10.1093/pch/16.9.581
PG 9
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA 843GJ
UT WOS:000296660000018
PM 23115502
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Choi, SJ
   Jung, SS
   You, YS
   Shin, BS
   Kim, JE
   Yoon, SW
   Jeon, DW
   Baek, JH
   Park, SW
   Lee, JG
   Kim, YH
AF Choi, Seok-Ju
   Jung, Sung-Soo
   You, Young-Sun
   Shin, Bae-Seob
   Kim, Ji-Eun
   Yoon, Sung-Wook
   Jeon, Dong-Wook
   Baek, Jun-Hyung
   Park, Sung-Woo
   Lee, Jung-Goo
   Kim, Young-Hoon
TI Prevalence of Alzheimer's Dementia and Its Risk Factors in
   Community-Dwelling Elderly Koreans
SO PSYCHIATRY INVESTIGATION
LA English
DT Article
DE Alzheimer's dementia; Mild cognitive impairment; Prevalence; Risk
   factor; Metabolic syndrome
ID MILD COGNITIVE IMPAIRMENT; METABOLIC SYNDROME; VASCULAR DEMENTIA;
   NEUROPSYCHOLOGICAL ASSESSMENT; APOE GENOTYPE; PLASMA-LIPIDS; DISEASE;
   POPULATION; CHOLESTEROL; CLASSIFICATION
AB Objective We estimated the prevalence of Alzheimer's dementia (AD) and mild cognitive impairment (MCI) and their risk factors in an urban Community setting, focusing especially on metabolic syndrome.
   Methods A two-phase investigation based on a door-to-door survey was performed. In Phase I, we administered the Korean version of the Mini-Mental State Examination (MMSE-KC) of the Consortium to Establish a Registry for Alzheimer's disease (CERAD-K). Assessment Packet and the Korean version of the Geriatric Depression Scales (GDS-K) to all 706 participants aged 65 years or older. In Phase II of the study, 175 persons underwent physical and neurological examinations according to the protocol of the CERAD-K clinical assessment battery [CERAD-K (C)] and the neuropsychological assessment battery [CERAD-K (N)]. We also examined the association between cognitive decline and metabolic syndrome. AD and MCI were defined using the DSM-IV-TR criteria and the Clinical Dementia Rating (CDR) scales.
   Results The mean age (+/- SD) of the subjects was 74.3 +/- 16.7 years and the ratio of males to females was 53.2 to 46.8. The prevalence of Alzheimer's dementia was 9.0%, while that of MCI was 32.9%. Old age and lower educational level had significant associations with cognitive decline in the elderly, but gender, years of alcohol intake or smoking, and metabolic syndrome were not associated with AD or MCI.
   Conclusion In this study, metabolic syndrome was not associated with Alzheimer's AD or MCI. Information regarding an association between Alzheimer's dementia and metabolic syndrome in this study will be helpful in formulating future public health policy and prevention strategies in Korea.
C1 [Kim, Young-Hoon] Inje Univ, Sch Med, Dept Psychiat, Pusan 614735, South Korea.
   [Choi, Seok-Ju] Dong Nam Mental Hosp, Dept Psychiat, Gimhae, South Korea.
   [Jung, Sung-Soo; You, Young-Sun; Shin, Bae-Seob; Kim, Ji-Eun; Yoon, Sung-Wook; Jeon, Dong-Wook; Baek, Jun-Hyung] Inje Univ, Coll Med, Dept Psychiat, Busan Paik Hosp, Pusan 614735, South Korea.
   [Park, Sung-Woo; Lee, Jung-Goo; Kim, Young-Hoon] Inje Univ, Paik Inst Clin Res, Pusan 614735, South Korea.
C3 Pusan National University; Pusan National University Hospital; Inje
   University; Inje University; Inje University
RP Kim, YH (corresponding author), Inje Univ, Sch Med, Dept Psychiat, 633-165 Gaegeum Dong, Pusan 614735, South Korea.
EM npkyh@chol.com
RI park, sung woo/JTS-5921-2023; Lee, Jung Goo/H-5563-2017
OI Lee, Jung Goo/0000-0003-3393-2667
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NR 54
TC 24
Z9 26
U1 0
U2 5
PU KOREAN NEUROPSYCHIATRIC ASSOC
PI SEOUL
PA RN 522, G-FIVE CENTRAL PLAZA 1685-8 SEOCHO 4-DONG, SEOCHO-GU, SEOUL,
   137-882, SOUTH KOREA
SN 1738-3684
EI 1976-3026
J9 PSYCHIAT INVEST
JI Psychiatry Investig.
PD JUN
PY 2008
VL 5
IS 2
BP 78
EP 85
DI 10.4306/pi.2008.5.2.78
PG 8
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychiatry
GA 435SG
UT WOS:000265363000003
PM 20046349
OA Green Submitted, Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Poudyal, H
   Lemonakis, N
   Efentakis, P
   Gikas, E
   Halabalaki, M
   Andreadou, I
   Skaltsounis, L
   Brown, L
AF Poudyal, Hemant
   Lemonakis, Nikolaos
   Efentakis, Panagiotis
   Gikas, Evangelos
   Halabalaki, Maria
   Andreadou, Ioanna
   Skaltsounis, Leandros
   Brown, Lindsay
TI Hydroxytyrosol ameliorates metabolic, cardiovascular and liver changes
   in a rat model of diet-induced metabolic syndrome: Pharmacological and
   metabolism-based investigation
SO PHARMACOLOGICAL RESEARCH
LA English
DT Article
DE Hydroxytyrosol; Olives; Olive oil; Metabolic syndrome; Cardiovascular;
   Obesity
ID VASCULAR ENDOTHELIAL-CELLS; CORONARY-HEART-DISEASE; OLIVE OIL
   POLYPHENOLS; MEDITERRANEAN DIET; HIGH-CARBOHYDRATE;
   BIOLOGICAL-ACTIVITIES; ANESTHETIZED RABBITS; OXIDATIVE STRESS;
   DOWN-REGULATION; HUMAN HEALTH
AB Metabolic syndrome is a clustering of interrelated risk factors for cardiovascular disease and diabetes. The Mediterranean diet has been proposed as an important dietary pattern to confer cardioprotection by attenuating risk factors of metabolic syndrome. Hydroxytyrosol (HT) is present in olive fruit and oil, which are basic constituents of the Mediterranean diet. In this study, we have shown that treatment with HT (20 mg/kg/d for 8 weeks) decreased adiposity, improved impaired glucose and insulin tolerance, improved endothelial function with lower systolic blood pressure, decreased left ventricular fibrosis and resultant diastolic stiffness and reduced markers of liver damage in a diet-induced rat model of metabolic syndrome. These results were accompanied by reduced infiltration of monocytes/macrophages into the heart with reduced biomarkers of oxidative stress. Furthermore, in an HRMS-based metabolism study of HT, we have identified 24 HT phase I and II metabolites, six of them being over-produced in high-starch, low-fat diet fed rats treated with HT compared to obese rats on high-carbohydrate, high-fat diet. These results provide direct evidence for cardioprotective effects of hydroxytyrosol by attenuation of metabolic risk factors. The implications of altered metabolism of HT in high-carbohydrate, high-fat diet fed obese rats warrant further investigation. (C) 2016 Elsevier Ltd. All rights reserved.
C1 [Poudyal, Hemant] Kyoto Univ, Hakubi Ctr Adv Res, Dept Diabet Endocrinol & Nutr, Kyoto, Japan.
   [Poudyal, Hemant; Brown, Lindsay] Univ Southern Queensland, Sch Hlth & Wellbeing, Toowoomba, Qld 4350, Australia.
   [Lemonakis, Nikolaos; Halabalaki, Maria; Skaltsounis, Leandros] Univ Athens, Fac Pharm, Dept Pharmacognosy & Nat Prod Chem, Athens 15771, Greece.
   [Efentakis, Panagiotis; Andreadou, Ioanna] Univ Athens, Fac Pharm, Pharmacol Lab, Athens 15771, Greece.
   [Gikas, Evangelos] Univ Athens, Fac Pharm, Dept Pharmaceut Chem, Athens 15771, Greece.
C3 Kyoto University; University of Southern Queensland; National &
   Kapodistrian University of Athens; National & Kapodistrian University of
   Athens; National & Kapodistrian University of Athens
RP Brown, L (corresponding author), Univ Southern Queensland, Sch Hlth & Wellbeing, Toowoomba, Qld 4350, Australia.; Skaltsounis, L (corresponding author), Univ Athens, Fac Pharm, Dept Pharmacognosy & Nat Prod Chem, Athens 15771, Greece.
EM skaltsounis@pharm.uoa.gr; Lindsay.Brown@usq.edu.au
RI Efentakis, Panagiotis/ABG-3175-2021; Poudyal, Hemant/HOH-9324-2023;
   Halabalaki, Maria/AAD-2127-2020; Andreadou, Ioanna/AAF-7284-2019; Gikas,
   Evagelos/H-6226-2019; skaltsounis, alexios/AAE-9617-2019
OI Efentakis, Panagiotis/0000-0001-8644-5796
FU University of Queensland Graduate School International Travel Award; 
   [02SMEs2010]; Grants-in-Aid for Scientific Research [17K15573] Funding
   Source: KAKEN
FX We would like to thank Dr Leigh Ward and Dr Glenda Gobe from The
   University of Queensland for dual energy X-ray absorptiometry and
   additional nutritional advice, and immunohistochemistry, respectively.
   We thank Mr Jason Brightwell, The Prince Charles Hospital, Brisbane,
   Australia for acquisition of echocardiographic images. We would also
   like to thank Mr Maharshi Bhaswant and Mr Anand Mistry for technical
   support. H.P. was supported by The University of Queensland Graduate
   School International Travel Award to undertake part of this study. Part
   of the work was funded by 02SMEs2010 Valorisation of table olive by
   products for the production of high added value extracts and products
   (2012-2015). The funders had no role in study design, data collection
   and analysis, decision to publish or preparation of the manuscript. No
   additional external funding was received for this study.
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NR 50
TC 41
Z9 43
U1 0
U2 22
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 1043-6618
J9 PHARMACOL RES
JI Pharmacol. Res.
PD MAR
PY 2017
VL 117
BP 32
EP 45
DI 10.1016/j.phrs.2016.12.002
PG 14
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA EN2MQ
UT WOS:000395845000004
PM 27940206
DA 2025-06-11
ER

PT J
AU Bensley, L
   VanEenwyk, J
   Ossiander, EM
AF Bensley, Lillian
   VanEenwyk, Juliet
   Ossiander, Eric M.
TI Associations of Self-Reported Periodontal Disease With Metabolic
   Syndrome and Number of Self-Reported Chronic Conditions
SO PREVENTING CHRONIC DISEASE
LA English
DT Article
ID CORONARY-HEART-DISEASE; NONRESPONSE RATES; HEALTH; RISK; PREVALENCE;
   IMPACT; BIAS
AB Introduction
   Increasing evidence supports associations between periodontal disease and various chronic conditions. Possible explanations include chronic inflammatory processes, shared pathogens, and shared risk factors, such as smoking and psychosocial stress. The objective of this study was to assess associations of periodontal disease with metabolic syndrome and number of chronic diseases.
   Methods
   As part of the Washington Adult Health Survey, a household-based cross-sectional study conducted during 2006-2007 among adults aged 25 years or older in Washington State, we collected questionnaire data, blood samples, and anthropometric measures. We used these data to assess associations of periodontal disease with metabolic syndrome and the number of self-reported chronic diseases, controlling for age, sex, annual household income, smoking, and psychosocial stress. We used both complete case and multiple imputation Poisson regression analyses.
   Results
   In the adjusted complete case analysis, 1.4 times as many chronic conditions were found among people with severe compared with no periodontal disease, and people with severe periodontal disease were 1.5 times more likely to have metabolic syndrome than people with no periodontal disease. Arthritis and liver disease were individually associated with severe periodontal disease. Results of the multiple imputation analyses were similar.
   Conclusion
   These results suggest that people with severe periodontal disease are likely to have more chronic diseases and are more likely to have metabolic syndrome compared with people without periodontal disease. Research about the effectiveness of periodontal treatment to help prevent or control chronic diseases is needed.
C1 [Bensley, Lillian] Washington State Dept Hlth, Off Epidemiol, Olympia, WA 98504 USA.
RP Bensley, L (corresponding author), Washington State Dept Hlth, Off Epidemiol, POB 47812, Olympia, WA 98504 USA.
EM Lillian.Bensley@doh.wa.gov
FU Centers for Disease Control and Prevention [U50/CCU021339-05]
FX This study was funded by the Centers for Disease Control and Prevention
   contract no. U50/CCU021339-05. These data were reported, in part, at the
   June 2010 annual meeting of the Society for Epidemiological Research in
   Seattle, Washington. We thank Joseli Alves-Dunkerson, DDS, MS, MPH, and
   Divesh Byrappagari, DDS, MSD, for their help in developing the oral
   health component of the study; Karen Krueger, RN, MN, and Katrina
   Wynkoop Simmons, PhD, for their help in developing the original
   proposal; Mary LeMier, MPH, for her assistance with developing the
   database, and Ramona Nelson for administrative assistance.
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NR 28
TC 20
Z9 25
U1 0
U2 1
PU CENTERS  DISEASE CONTROL & PREVENTION
PI ATLANTA
PA 1600 CLIFTON RD, ATLANTA, GA 30333 USA
SN 1545-1151
J9 PREV CHRONIC DIS
JI Prev. Chronic Dis.
PD MAY
PY 2011
VL 8
IS 3
AR A50
PG 10
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA 874OR
UT WOS:000298968400001
PM 21477490
DA 2025-06-11
ER

PT J
AU Tajmohammadi, A
   Razavi, BM
   Hosseinzadeh, H
AF Tajmohammadi, Atefeh
   Razavi, Bibi Marjan
   Hosseinzadeh, Hossein
TI Silybum marianum (milk thistle) and its main constituent,
   silymarin, as a potential therapeutic plant in metabolic syndrome: A
   review
SO PHYTOTHERAPY RESEARCH
LA English
DT Review
DE diabetes; dyslipidemia; hypertension; metabolic syndrome; milk thistle;
   obesity; silibyn; Silybum marianum; silymarin
ID FIXED COMBINATION; OXIDATIVE STRESS; PATIENTS INTOLERANT;
   INSULIN-RESISTANCE; BERBERIS-ARISTATA; LIPID PROFILE; DOUBLE-BLIND;
   FATTY LIVER; LONG-TERM; SILIBININ
AB Metabolic syndrome describes a complex metabolic risk factors including obesity, hypertension, dyslipidemia, and diabetes. This syndrome is diagnosed by medical conditions such as weight gain, high blood pressure, high blood glucose, and disturbance in lipid profile. Metabolic syndrome has become as an important and increasing global health problem, so finding potentially novel solutions with less adverse effects is favorable for health problems. Herbal therapy plays an important role for treatment of different diseases. Silybum marianum is a plant that is used for centuries as a herbal treatment in liver and biliary tract diseases. Silymarin is the main component of S.marianum and derived from fruits and seeds of S.marianum (milk thistle). S.marianum has been found to exhibit antioxidant, lipid-lowering, antihypertensive, antidiabetic, antiatherosclerotic, anti-obesity, and hepatoprotective effects. Therefore, the aim of this review is to summarize different animal and human studies regarding the effect of S.marianum in metabolic syndrome and to identify the underlying mechanisms of action.
C1 [Tajmohammadi, Atefeh] Mashhad Univ Med Sci, Sch Pharm, Mashhad, Iran.
   [Razavi, Bibi Marjan] Mashhad Univ Med Sci, Targeted Drug Delivery Res Ctr, Pharmaceut Technol Inst, Mashhad, Iran.
   [Hosseinzadeh, Hossein] Mashhad Univ Med Sci, Pharmaceut Res Ctr, Pharmaceut Technol Inst, Mashhad, Iran.
   [Razavi, Bibi Marjan; Hosseinzadeh, Hossein] Mashhad Univ Med Sci, Sch Pharm, Dept Pharmacodynam & Toxicol, Mashhad, Iran.
C3 Mashhad University of Medical Sciences; Mashhad University of Medical
   Sciences; Mashhad University of Medical Sciences; Mashhad University of
   Medical Sciences
RP Hosseinzadeh, H (corresponding author), Mashhad Univ Med Sci, Pharmaceut Res Ctr, Pharmaceut Technol Inst, Mashhad, Iran.
EM hosseinzadehh@mums.ac.ir
RI Hosseinzadeh, Hossein/F-3013-2010; razavi, Bibi Marjan/AAY-5636-2020
OI Hosseinzadeh, Hossein/0000-0002-3483-851X; razavi, Bibi
   Marjan/0000-0002-7450-9286
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NR 68
TC 100
Z9 106
U1 2
U2 39
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0951-418X
EI 1099-1573
J9 PHYTOTHER RES
JI Phytother. Res.
PD OCT
PY 2018
VL 32
IS 10
BP 1933
EP 1949
DI 10.1002/ptr.6153
PG 17
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA GW0NW
UT WOS:000446565300006
PM 30015401
DA 2025-06-11
ER

PT J
AU Dong, ML
   Ren, J
AF Dong, Maolong
   Ren, Jun
TI What Fans the Fire: Insights into Mechanisms of Leptin in Metabolic
   Syndrome-Associated Heart Diseases
SO CURRENT PHARMACEUTICAL DESIGN
LA English
DT Article
DE Leptin; leptin resistance; cardiovascular disease; metabolic syndrome
ID ENDOTHELIAL NITRIC-OXIDE; PLASMA LEPTIN; INSULIN-RESISTANCE; VENTRICULAR
   MYOCYTES; CIRCULATING LEPTIN; BLOOD-PRESSURE; PHOSPHOINOSITIDE 3-KINASE;
   CARDIOVASCULAR-DISEASE; CONTRACTILE RESPONSE; CARDIAC-FUNCTION
AB Obesity and metabolic syndrome are one of the most devastating risk factors for cardiovascular diseases. The obesity gene product leptin plays a central role in the regulation of food intake and energy expenditure. The physiological and pathophysiological roles of leptin in cardiovascular system have been investigated extensively since its discovery in 1994. In addition to its well-established metabolic effects, more recent evidence have depicted a rather pivotal role of leptin in inflammation, oxidative stress, endoplasmic reticulum stress, apoptosis and tissue remodeling en route to the pathogenesis of type 2 diabetes mellitus, hypertension, atherosclerosis, and insulin resistance. Under physiological condition, leptin is known to reduce appetite, promote energy expenditure, increase sympathetic activity, facilitate glucose utilization and improve insulin sensitivity. In addition, leptin may regulate cardiac and vascular function through a nitric oxide-dependent mechanism. However, hyperleptinemia usually occurs with progressively increased body weight and metabolic syndrome development, leading to a state of global or selective leptin resistance. Both central and peripheral leptin resistance may be present under pathophysiological conditions such as inflammation, insulin resistance, hyperlipidemia and a cadre of other cardiovascular diseases including hypertension, atherosclerosis, obesity, ischemic heart disease and heart failure. In this review, we will discuss cardiovascular actions of leptin related to various components of metabolic syndrome. Particular emphasis will be given to insights derived from therapeutic interventions with lifestyle modification, cardiovascular drugs, anti-diabetic and anti-obesity drugs.
C1 [Dong, Maolong; Ren, Jun] Fourth Mil Med Univ, Xijing Hosp, Dept Burn & Cutaneous Surg, Xian 710032, Peoples R China.
   [Dong, Maolong; Ren, Jun] Univ Wyoming, Coll Hlth Sci, Ctr Cardiovasc Res & Alternat Med, Laramie, WY 82071 USA.
C3 Air Force Medical University; University of Wyoming
RP Ren, J (corresponding author), Univ Wyoming, Coll Hlth Sci, Ctr Cardiovasc Res & Alternat Med, Laramie, WY 82071 USA.
EM jren@uwyo.edu
RI Ren, Jun/ACG-5366-2022
OI Ren, Jun/0000-0002-0275-0783
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NR 143
TC 46
Z9 51
U1 0
U2 13
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1381-6128
EI 1873-4286
J9 CURR PHARM DESIGN
JI Curr. Pharm. Design
PD FEB
PY 2014
VL 20
IS 4
BP 652
EP 658
DI 10.2174/138161282004140213160930
PG 7
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA AE9DV
UT WOS:000334305800021
PM 23688014
DA 2025-06-11
ER

PT J
AU Meikle, PJ
   Christopher, MJ
AF Meikle, Peter J.
   Christopher, Michael J.
TI Lipidomics is providing new insight into the metabolic syndrome and its
   sequelae
SO CURRENT OPINION IN LIPIDOLOGY
LA English
DT Review
DE insulin resistance; lipidomics; metabolic syndrome; steatosis; type 2
   diabetes
ID SEPARATED LIPOPROTEIN FRACTIONS; TANDEM MASS-SPECTROMETRY;
   INSULIN-RESISTANCE; SHOTGUN LIPIDOMICS; RESPIRATORY-CHAIN; HEPATIC
   STEATOSIS; HUMAN PLASMA; CARDIOLIPIN; LOCI; ANTIOXIDANTS
AB Purpose of review
   The metabolic syndrome incorporating obesity, hypertension, dyslipidaemia and elevated plasma glucose has reached epidemic proportions in many Western countries leading to a dramatic increase in insulin resistance, steatosis and type 2 diabetes. Lipidomics presents a new set of tools to unravel the relationship between hyper-caloric diets and other environmental and genetic factors with the metabolic syndrome and disease progression.
   Recent findings
   Plasma lipidomic studies are providing detailed characterisation of the dyslipidaemia associated with obesity and the metabolic syndrome. Combined with lipoprotein fractionation and dynamic modelling we are gaining a new comprehension of lipoprotein composition structure and function. At the population level genome-wide association studies are identifying potential loci linking lipid metabolism with disease pathogenesis. Analysis of tissue, cell and even organelle lipidomes are unravelling the complex relationships between lipotoxicity, inflammation, oxidative stress and cellular function.
   Summary
   The global view of lipid metabolism offered by lipidomics is accelerating our understanding of disease processes and identifying new avenues of research into metabolic syndrome and its sequelae. The ongoing identification and validation of lipid biomarkers will likely see their introduction into clinical practice for improved quantification of disease risk, earlier identification of disease and improved patient management in the near future.
C1 Monash Univ, Baker IDI Heart & Diabet Inst, Melbourne, Vic 3004, Australia.
   Monash Univ, Dept Med, Melbourne, Vic 3004, Australia.
C3 Monash University; Baker Heart and Diabetes Institute; Monash University
RP Meikle, PJ (corresponding author), POB 6492,St Kilda Rd Cent, Melbourne, Vic 8008, Australia.
EM peter.meikle@bakeridi.edu.au
RI Meikle, Peter/B-4023-2009
OI Meikle, Peter/0000-0002-2593-4665
FU National Health and Medical Research Council of Australia
FX The authors have no conflict of interest. P.J.M. holds a senior research
   fellowship from the National Health and Medical Research Council of
   Australia.
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NR 36
TC 86
Z9 90
U1 0
U2 46
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0957-9672
J9 CURR OPIN LIPIDOL
JI Curr. Opin. Lipidology
PD JUN
PY 2011
VL 22
IS 3
BP 210
EP 215
DI 10.1097/MOL.0b013e3283453dbe
PG 6
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism; Peripheral
   Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism;
   Cardiovascular System & Cardiology
GA 762XE
UT WOS:000290514700010
PM 21378565
DA 2025-06-11
ER

PT J
AU Rajapakse, NW
   Head, GA
   Kaye, DM
AF Rajapakse, Niwanthi W.
   Head, Geoffrey A.
   Kaye, David M.
TI Say NO to Obesity-Related Hypertension Role of the L-Arginine-Nitric
   Oxide Pathway
SO HYPERTENSION
LA English
DT Review
ID ANGIOTENSIN-CONVERTING ENZYME; SYMPATHETIC-NERVE ACTIVITY; REDUCES
   OXIDATIVE STRESS; FAT-FED RABBITS; BLOOD-PRESSURE; ENDOTHELIAL
   DYSFUNCTION; METABOLIC SYNDROME; HEART-FAILURE; IN-VIVO; INCIDENT
   HYPERTENSION
C1 [Rajapakse, Niwanthi W.; Head, Geoffrey A.; Kaye, David M.] Baker IDI Heart & Diabet Inst, Melbourne, Vic 3004, Australia.
   [Kaye, David M.] Monash Univ, Dept Med, Melbourne, Vic 3004, Australia.
   [Rajapakse, Niwanthi W.] Monash Univ, Dept Physiol, Melbourne, Vic 3168, Australia.
C3 Baker Heart and Diabetes Institute; Monash University; Monash University
RP Rajapakse, NW (corresponding author), Baker IDI Heart & Diabet Inst, Heart Failure Res Grp, 75 Commercial Rd, Melbourne, Vic 3004, Australia.
EM ssniwanthi.rajapakse@bakeridi.edu.au
RI Kaye, David/AAF-1202-2021; Head, Geoffrey/B-2177-2010
OI Rajapakse, Niwanthi/0000-0001-9777-1087; Head,
   Geoffrey/0000-0002-7623-137X; Kaye, David/0000-0003-4058-0372
FU National Health and Medical Research Council (NHMRC); CASS Medicinal
   project; Victorian Government's Operational Infrastructure Support
   Program
FX Our work was supported by a National Health and Medical Research Council
   (NHMRC) Program Grant to D.M. Kaye and a CASS Medicinal project grant to
   N.W. Rajapakse and also, in part, by the Victorian Government's
   Operational Infrastructure Support Program.
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NR 72
TC 27
Z9 31
U1 0
U2 9
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0194-911X
EI 1524-4563
J9 HYPERTENSION
JI Hypertension
PD MAY
PY 2016
VL 67
IS 5
BP 813
EP 819
DI 10.1161/HYPERTENSIONAHA.116.06778
PG 7
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA DK2WZ
UT WOS:000374776400057
PM 27021014
OA Bronze
DA 2025-06-11
ER

PT J
AU El-kady, DS
   Mabrouk, M
   Kotob, SE
   Abdelhalim, MM
   Elmegeed, GA
   Behierei, HH
   Ahmed, HH
AF El-kady, Dina S.
   Mabrouk, Mostafa
   Kotob, Soheir E.
   Abdelhalim, Mervat M.
   Elmegeed, Gamal A.
   Behierei, Hanan H.
   Ahmed, Hanaa H.
TI Evaluation of Mesoporous Silica Nanoparticles as Delivery Vehicles for
   Novel Hybrid Steroids in Management of Metabolic Syndrome in Mice
SO EGYPTIAN JOURNAL OF CHEMISTRY
LA English
DT Article
DE mesoporous silica; nanoparticles drug delivery; hybrid steroids;
   metabolic syndrome; mice
ID INSULIN-RESISTANCE; OXIDATIVE STRESS; ADIPOSE-TISSUE;
   LIPID-PEROXIDATION; FRUCTOSE; OBESITY; GLUCOSE; WEIGHT; ANTICANCER;
   SPEXIN
AB This approach aimed to address the efficacy of the newly synthesized hybrid steroids modified by sulfurheterogenous rings and loaded on mesoporous silica nanoparticles in manipulating metabolic syndrome induced by high fructose diet. The designed compounds were synthesized by mechanochemical process and then loaded on mesoporous silica nanoparticles as drug delivery vehicles. Thereafter, these compounds were examined for counteracting metabolic syndrome inmice. The synthesized compounds revealed potentiality to prevent body weight gain as indicated by the decreased BMI of the mice fed high fructose diet. The hypolipidemic effect of the designed compounds was evidenced by the reduction of serum cholesterol, triglycerides, LDL-cholesterol and the enhancement of HDL-cholesterol levels. Moreover, the compounds displayed a significant decline in blood glucose and insulin levels. So, they exhibited significant betterment in insulin resistance of the treated mice. Furthermore, the treatment with these compounds improved serum spexin level in metabolic syndrome challenged mice. Ultimately, the tested compounds demonstrated powerful free radical scavenging activity manifested by lowering MDA, NO and H2O2 serum levels. Conclusively, the newly modified hybrid steroid compounds proved good performance against metabolic syndrome in mice most probably due to their content of sulfur atom, in addition to their loading on mesoporous silica nanoparticles.
C1 [El-kady, Dina S.; Kotob, Soheir E.; Abdelhalim, Mervat M.; Elmegeed, Gamal A.; Ahmed, Hanaa H.] Natl Res Ctr, Med Res Div, Hormones Dept, Giza, Egypt.
   [Mabrouk, Mostafa; Behierei, Hanan H.] Natl Res Ctr, Refractories Ceram & Bldg Mat Biomat Dept, Giza, Egypt.
C3 Egyptian Knowledge Bank (EKB); National Research Centre (NRC); Egyptian
   Knowledge Bank (EKB); National Research Centre (NRC)
RP Ahmed, HH (corresponding author), Natl Res Ctr, Med Res Div, Hormones Dept, Giza, Egypt.
EM hanaaomr@yahoo.com
RI Elmegeed, Gamal/AAD-6191-2019; Kotob, Soheir/P-3341-2015
OI Elmegeed, Gamal/0000-0003-1914-1543
FU National Research Centre, Cairo, Egypt (NRC)
FX Funding This work was financially supported by National Research Centre,
   Cairo, Egypt (NRC) .
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NR 90
TC 1
Z9 1
U1 0
U2 0
PU National Information & Documentation Centre-NIDOC
PI CAIRO
PA NIDOC DOKKI, CAIRO, 00000, EGYPT
SN 0449-2285
EI 2357-0245
J9 EGYPT J CHEM
JI Egypt. J. Chem.
PD OCT
PY 2021
VL 64
IS 10
BP 5813
EP 5830
DI 10.21608/EJCHEM.2021.57952.3295
PG 18
WC Chemistry, Multidisciplinary
WE Emerging Sources Citation Index (ESCI)
SC Chemistry
GA WC6GO
UT WOS:000704354800040
OA Bronze
DA 2025-06-11
ER

PT J
AU Raatikainen, I
   Mäntyselkä, P
   Vanhala, M
   Heinonen, A
   Koponen, H
   Kautiainen, H
   Korniloff, K
AF Raatikainen, Ilkka
   Mantyselka, Pekka
   Vanhala, Mauno
   Heinonen, Ari
   Koponen, Hannu
   Kautiainen, Hannu
   Korniloff, Katariina
TI Leisure time physical activity and its relation to psychiatric
   comorbidities in depression. Findings from Finnish Depression and
   Metabolic Syndrome in Adults (FDMSA) study
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Depression; Leisure time physical activity; Psychiatric comorbidities
ID SYMPTOMS; DISEASE; BURDEN; ASSOCIATION; DISORDERS; MORTALITY; EXERCISE;
   ANXIETY; PEOPLE
AB Purpose: The study aim was to examine association between leisure time physical activity (LTPA) and psychiatric comorbidities among people with depression.
   Methods: Total 447 patients aged 35 years and older suffering from depressive symptoms (DS) and who were confirmed depression positive participated this study. The study was conducted between 2008 and 2011 in municipalities within Central Finland Hospital District. DS were determined with Beck Depression Inventory (BDI-21) with cutoff score >= 10 and psychiatric diagnoses were confirmed by Mini-International Neuropsychiatric Interview (M.I.N.I.). LTPA, other diseases as well as use of antidepressant were captured by self-reported questionnaire. Participants also took part in physical examination. The associations between LTPA and psychiatric comorbidities were analyzed using generalized linear models.
   Results: LTPA level was not related to number of psychiatric comorbidities (after adjustment for age, gender, BMI, BDI and use of antidepressant p = 0.24) among depressed patients. The higher levels of LTPA were linearly associated with lower cardiovascular diseases (p = 0.036) and obesity (p = 0.006) as well as fewer DS < 0.001) among depressed patients.
   Limitations: Possibility of LTPA level overestimation and study results generalizability to younger persons.
   Conclusions: According to this study, LTPA level is not associated with psychiatric comorbidities among depressed patients in Finnish adult population. However, our results showed that the higher the LTPA level was, the less the participants suffered from depressive symptoms. In addition, higher levels of physical activity were associated with fewer heart diseases and obesity outlining the importance of overall health-care and health promotion although other forms of treatment are also needed.
C1 [Raatikainen, Ilkka; Heinonen, Ari] Univ Jyvaskyla, Fac Sport & Hlth Sci, POB 35, FI-40014 Jyvaskyla, Finland.
   [Raatikainen, Ilkka] Cent Finland Hlth Care Dist, Assist Technol Ctr, Jyvaskyla, Finland.
   [Mantyselka, Pekka; Vanhala, Mauno] Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland.
   [Mantyselka, Pekka; Kautiainen, Hannu] Kuopio Univ Hosp, Primary Hlth Care Unit, Kuopio, Finland.
   [Koponen, Hannu] Univ Helsinki, Dept Psychiat, Old Age Psychiat, Helsinki, Finland.
   [Koponen, Hannu] Helsinki Univ Hosp, Psychiat, Helsinki, Finland.
   [Kautiainen, Hannu] Folkhalsan Res Ctr, Helsinki, Finland.
   [Korniloff, Katariina] JAMK Univ Appl Sci, Sch Hlth & Social Studies, Jyvaskyla, Finland.
C3 University of Jyvaskyla; Central Finland Central Hospital; University of
   Eastern Finland; University of Eastern Finland; University of Eastern
   Finland Hospital; Kuopio University Hospital; University of Helsinki;
   University of Helsinki; Helsinki University Central Hospital; Folkhalsan
   Research Center; Jyvaskyla University of Applied Sciences
RP Raatikainen, I (corresponding author), Univ Jyvaskyla, Fac Sport & Hlth Sci, POB 35, FI-40014 Jyvaskyla, Finland.
EM ilkka.t.raatikainen@student.jyu.fi
RI ; Heinonen, Ari/A-9199-2014
OI Koponen, Hannu/0000-0002-7368-1869; Korniloff,
   Katariina/0000-0002-0753-1483; Heinonen, Ari/0000-0002-3681-9953;
   Raatikainen, Ilkka/0000-0002-4040-9666
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NR 22
TC 12
Z9 12
U1 1
U2 28
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD DEC 1
PY 2019
VL 259
BP 150
EP 153
DI 10.1016/j.jad.2019.08.039
PG 4
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA JC4OZ
UT WOS:000489257500023
PM 31445341
OA Green Submitted, Green Accepted
DA 2025-06-11
ER

PT J
AU Gu, JK
   Charles, LE
   Allison, P
   Violanti, JM
   Andrew, ME
AF Gu, Ja K.
   Charles, Luenda E.
   Allison, Penelope
   Violanti, John M.
   Andrew, Michael E.
TI Association Between the Metabolic Syndrome and Retinal Microvascular
   Diameters Among Police Officers
SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
LA English
DT Article
DE metabolic syndrome; retinal microvascular; CRAE; CRVE; police officers
ID SIGNS; PREVALENCE; RISK; POPULATION; CALIBER
AB Objectives We examined the associations of the metabolic syndrome severity score (MSSS) and the metabolic syndrome (MetSyn) components with central retinal arteriolar equivalent (CRAE) and central retinal venular equivalent (CRVE). Methods Participants in this cross-sectional study were 253 officers from the Buffalo Cardio-Metabolic Occupational Police Stress study (2011-2014). The MSSS is a z-score that represents the severity of MetSyn and was estimated using a sex/race-specific equation and the five MetSyn components. Associations of MSSS and the MetSyn with CRAE/CRVE were obtained using linear regression models or analysis of covariance. Results For every 1-standard deviation of MSSS, CRAE decreased by 2.3 mu m (SE = 1.2, P = 0.0262) and CRVE increased by 3.4 mu m (SE = 1.6, P = 0.0308) after adjusting for confounders. Conclusions Officers with higher MSSS had narrower (ie, worse) arteriolar diameters and wider (ie, worse) venular diameters.
C1 [Gu, Ja K.; Charles, Luenda E.; Allison, Penelope; Andrew, Michael E.] Ctr Dis Control & Prevent, Bioanalyt Branch, Hlth Effects Lab Div, Natl Inst Occupat Safety & Kalth, MS L-4050,1095 Willowdale Rd, Morgantown, WV 26505 USA.
   [Violanti, John M.] SUNY Buffalo, Dept Epidemiol & Environm Hlth, Sch Publ Hlth & Hlth Profess, Buffalo, NY USA.
C3 Centers for Disease Control & Prevention - USA; State University of New
   York (SUNY) System; University at Buffalo, SUNY
RP Gu, JK (corresponding author), Ctr Dis Control & Prevent, Bioanalyt Branch, Hlth Effects Lab Div, Natl Inst Occupat Safety & Kalth, MS L-4050,1095 Willowdale Rd, Morgantown, WV 26505 USA.
EM JGu@cdc.gov
RI Charles, Luenda/H-6008-2011
OI /0000-0002-0245-5899
FU National Institute for Occupational Safety and Health [200-2012-50561,
   1R01OH 009640-01A1]
FX This work was supported by the National Institute for Occupational
   Safety and Health (contract no. 200-2012-50561 and grant no. 1R01OH
   009640-01A1).
CR Amer Diabet Assoc, 2010, DIABETES CARE, V33, pS11, DOI [10.2337/dc10-S011, 10.2337/dc10-S062, 10.2337/dc13-S011, 10.2337/dc13-S067, 10.2337/dc11-S011, 10.2337/dc14-S081, 10.2337/dc12-s064, 10.2337/dc11-S062, 10.2337/dc12-s011]
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NR 25
TC 3
Z9 3
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1076-2752
EI 1536-5948
J9 J OCCUP ENVIRON MED
JI J. Occup. Environ. Med.
PD SEP
PY 2022
VL 64
IS 9
BP 748
EP 753
DI 10.1097/JOM.0000000000002569
PG 6
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA 4G2JJ
UT WOS:000849029400017
PM 35732034
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Rodrigues, MH
   Bruno, AS
   Nahas-Neto, J
   Santos, MES
   Nahas, EAP
AF Rodrigues, Marcio H.
   Bruno, Anderson S.
   Nahas-Neto, Jorge
   Santos, Maria Emilia S.
   Nahas, Eliana A. P.
TI Nonalcoholic fatty liver disease and metabolic syndrome in
   postmenopausal women
SO GYNECOLOGICAL ENDOCRINOLOGY
LA English
DT Article
DE Menopause; metabolic syndrome; nonalcoholic fatty liver disease
ID RISK-FACTORS; ADIPONECTIN LEVELS; ADVANCED FIBROSIS; BODY-COMPOSITION;
   PREVALENCE; DIAGNOSIS; OBESITY; STEATOHEPATITIS; CONSEQUENCES;
   PATHOGENESIS
AB Nonalcoholic fatty liver disease (NAFLD) is considered the most common cause of chronic liver disease in the Western countries. NAFLD includes a spectrum ranging from a simple steatosis to a nonalcoholic steatohepatitis (NASH) which is defined by the presence of inflammatory infiltrate, cellular necrosis, hepatocyte ballooning, and fibrosis and cirrhosis that can eventually develop into hepatocellular carcinoma. Studies emphasize the role of insulin resistance, oxidative stress, pro-inflammatory cytokines, adipokines in the development and progression of NAFLD. It seems to be independently associated with type II diabetes mellitus, increased triglycerides, decreased HDL-cholesterol, abdominal obesity and insulin resistance. These findings are in accordance with the criteria used in the diagnosis of metabolic syndrome (MetS). Here, we will discuss the current knowledge on the epidemiology, pathophysiology and diagnosis of NAFLD and the association of metabolic syndrome in postmenopausal women.
C1 [Rodrigues, Marcio H.; Bruno, Anderson S.; Nahas-Neto, Jorge; Nahas, Eliana A. P.] Sao Paulo State Univ, Botucatu Med Sch, Dept Gynecol & Obstet, Sao Paulo, Brazil.
   [Rodrigues, Marcio H.] Univ Fed Ouro Preto, Dept Gynecol & Obstet, Ouro Preto, MG, Brazil.
   [Santos, Maria Emilia S.] Univ Fed Sao Joao del Rei, Lab Metab Biochem, Divinopolis, MG, Brazil.
C3 Universidade Estadual Paulista; Universidade Federal de Sao Joao del-Rei
RP Nahas, EAP (corresponding author), Univ Estadual Paulista UNESP, Fac Med Botucatu, Dept Obstet & Ginecol, Dist Rubiao Jr S-N, BR-18618970 Botucatu, SP, Brazil.
EM epetri@fmb.unesp.br
RI Santos, Maria Emília/MHR-4328-2025; Nahas, Eliana/AAG-6249-2019
OI Nahas, Eliana/0000-0002-0803-8535
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NR 69
TC 15
Z9 16
U1 0
U2 13
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0951-3590
EI 1473-0766
J9 GYNECOL ENDOCRINOL
JI Gynecol. Endocrinol.
PD MAY
PY 2014
VL 30
IS 5
BP 325
EP 329
DI 10.3109/09513590.2013.875992
PG 5
WC Endocrinology & Metabolism; Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Obstetrics & Gynecology
GA AF5HA
UT WOS:000334743400001
PM 24460502
DA 2025-06-11
ER

PT J
AU Alam, I
   Lewis, K
   Stephens, JW
   Baxter, JN
AF Alam, I.
   Lewis, K.
   Stephens, J. W.
   Baxter, J. N.
TI Obesity, metabolic syndrome and sleep apnoea: all pro-inflammatory
   states
SO OBESITY REVIEWS
LA English
DT Review
DE inflammation; metabolic syndrome; obesity; obstructive sleep apnoea
ID NECROSIS-FACTOR-ALPHA; PROTEIN-KINASE-C; I-KAPPA-B; INSULIN-RESISTANCE;
   ADIPOSE-TISSUE; TNF-ALPHA; PROMOTER POLYMORPHISM; FATTY-ACIDS;
   HYPERTENSION; ASSOCIATION
AB Obesity is associated with significant morbidity and mortality and is increasing in prevalence worldwide. Associated conditions include insulin resistance (IR), diabetes, hypertension and dyslipidaemia; a clustering of these has recently been termed as metabolic syndrome. Weight gain is a major predictor of the metabolic syndrome with waist circumference being a more sensitive indicator than body mass index as it reflects both abdominal subcutaneous adipose tissue and visceral adipose tissue (VAT). VAT has more metabolic activity and secretes a number of hormones and pro-inflammatory cytokines which are linked with the metabolic abnormalities listed above. Central obesity also increases the risk of obstructive sleep apnoea syndrome (OSAS), where the sleep disordered breathing may also independently lead to/or exacerbate IR, diabetes and cardiovascular risk. The contribution of OSAS to the metabolic syndrome has been under-recognized. The putative mechanisms by which OSAS causes or exacerbates these other abnormalities are discussed. We propose that activation of nuclear factor kappa B by stress hypoxia and/or by increased adipokines and free fatty acids released by excess adipose tissue is the final common inflammatory pathway linking obesity, OSAS and the metabolic syndrome both individually and, in many cases, synergistically.
C1 Univ Wales Swansea, Morriston Hosp, Dept Surg, Swansea, W Glam, Wales.
   Univ Wales Swansea, Sch Med, Swansea, W Glam, Wales.
   Prince Philip Hosp, Llanelli, England.
C3 Swansea University; Morriston Hospital; Swansea University
RP Baxter, JN (corresponding author), Morriston Hosp, Dept Surg, Swansea SA6 6NL, W Glam, Wales.
EM john.baxter@swansea-tr.wales.nhs.uk
RI ; Lewis, Keir/JNS-8946-2023
OI Lewis, Keir/0000-0001-9756-4723; Lewis, Keir/0000-0002-8248-6774
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NR 107
TC 139
Z9 158
U1 0
U2 14
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1467-7881
EI 1467-789X
J9 OBES REV
JI Obes. Rev.
PD MAR
PY 2007
VL 8
IS 2
BP 119
EP 127
DI 10.1111/j.1467-789X.2006.00269.x
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 134QK
UT WOS:000244098600004
PM 17300278
DA 2025-06-11
ER

PT J
AU Belcaro, G
   Ledda, A
   Hu, S
   Cesarone, MR
   Feragalli, B
   Dugall, M
AF Belcaro, Gianni
   Ledda, Andrea
   Hu, Shu
   Cesarone, Maria Rosa
   Feragalli, Beatrice
   Dugall, Mark
TI Greenselect Phytosome for Borderline Metabolic Syndrome
SO EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Article
ID GREEN TEA; FAT OXIDATION; EPIGALLOCATECHIN GALLATE; INSULIN-RESISTANCE;
   ENERGY-EXPENDITURE; GLUCOSE-TOLERANCE; CORONARY EVENTS; ABDOMINAL FAT;
   WEIGHT-LOSS; OBESITY
AB The beneficial effects of Greenselect Phytosome, a proprietary lecithin formulation of a caffeine-free green tea catechin extract, were evaluated in a controlled registry study on 50 asymptomatic subjects borderline for metabolic syndrome factors and with increased plasma oxidative stress. After 24 weeks of intervention, improvement in weight, blood lipid profile, and blood pressure positioned 68% of subjects in the treatment arm out of the metabolic syndrome profile, while 80% of the subjects in the control group still remained in their initial borderline disease signature. Compared to the control (lifestyle and dietary changes alone), Greenselect Phytosome was especially effective for weight/waist changes. These results highlight the relevance of addressing multiple factors involved in the development of metabolic syndrome with a pleiotropic agent capable of improving the beneficial effects of lifestyle and dietary changes and foster the attainment of a globally improved health profile.
C1 [Belcaro, Gianni] Gabriele DAnnunzio Univ, Dept Biomed Sci, Circulat Vasc Labs Irvine3, Chieti, Italy.
   Gabriele DAnnunzio Univ, San Valentino Vasc Screening Project, Chieti, Italy.
C3 G d'Annunzio University of Chieti-Pescara; G d'Annunzio University of
   Chieti-Pescara
RP Belcaro, G (corresponding author), Gabriele DAnnunzio Univ, Dept Biomed Sci, Circulat Vasc Labs Irvine3, Chieti, Italy.
EM cardres@abol.it
OI Feragalli, Beatrice/0000-0002-6222-024X
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NR 58
TC 16
Z9 17
U1 0
U2 2
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1741-427X
EI 1741-4288
J9 EVID-BASED COMPL ALT
JI Evid.-based Complement Altern. Med.
PY 2013
VL 2013
AR 869061
DI 10.1155/2013/869061
PG 7
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA 255WR
UT WOS:000327271300001
PM 24348726
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Milà, C
   Ranzani, O
   Sanchez, M
   Ambrós, A
   Bhogadi, S
   Kinra, S
   Kogevinas, M
   Dadvand, P
   Tonne, C
AF Mila, Carles
   Ranzani, Otavio
   Sanchez, Margaux
   Ambros, Albert
   Bhogadi, Santhi
   Kinra, Sanjay
   Kogevinas, Manolis
   Dadvand, Payam
   Tonne, Cathryn
TI Land-Use Change and Cardiometabolic Risk Factors in an Urbanizing Area
   of South India: A Population-Based Cohort Study
SO ENVIRONMENTAL HEALTH PERSPECTIVES
LA English
DT Article
ID GREENSPACE; MORTALITY; EXPOSURE; GREENNESS; PACKAGE; COVER; KML
AB BACKGROUND: Land-use changes in city fringes due to urbanization can lead to a reduction of greenspace that may reduce its associated health benefits.
   OBJECTIVES: We evaluated the association between changes in residential surrounding built-up land use and cardiometabolic risk factors in an urbanizing pen -urban area of south India and explored the mediating roles of air pollution, physical activity, and stress in these associations.
   METHODS: We analyzed data on 6,039 adults from the third follow-up of the Andhra Pradesh Children and Parent Study (APCAPS) cohort (2010-2012). We generated trajectories of change in residential surrounding built-up land use (buffer areas) from 1995-2009 (stable, slow increase, fast increase) using remote sensing data and image classification methods. We estimated associations between built-up land use trajectories and natural log-transformed blood pressure, waist circumference, triglycerides, fasting glucose, and non-high-density lipoprotein (non-HDL) cholesterol using linear mixed models. We accounted for multiple mediators and the multilevel structure of the data in mediation analyses.
   RESULTS: We observed positive associations between a fast increase in built-up land use within 300 m of the home and all cardiometabolic risk factors. Compared with participants with stable trajectories, those with the largest increase in built-up land use had 1.5% (95% CI: 0.1, 2.9) higher systolic blood pressure, 2.4% (95% CI: 0.6, 4.3) higher diastolic blood pressure, 2.1% (95% CI: 0.5, 3.8) higher waist circumference, and 1.6% (95% CI: -0.6, 3.8) higher fasting glucose in fully adjusted models. Associations were positive, but not statistically significant, for triglycerides, fasting glucose, and non-HDL cholesterol. Physical activity and ambient particulate matter <= 2.5 mu m in aerodynamic diameter (PM2.5) partially mediated the estimated associations. Associations between fast build-up and all cardiometabolic risk factors except non-HDL cholesterol were stronger in women than men.
   DISCUSSION: Increases in built-up land use surrounding residences were consistently associated with higher levels of cardiometabolic risk factors. Our findings support the need for better integration of health considerations in urban planning in rapidly urbanizing settings.
C1 [Mila, Carles; Ranzani, Otavio; Ambros, Albert; Kogevinas, Manolis; Dadvand, Payam; Tonne, Cathryn] Barcelona Inst Global Hlth ISGlobal, Barcelona, Spain.
   [Mila, Carles; Ranzani, Otavio; Ambros, Albert; Kogevinas, Manolis; Dadvand, Payam; Tonne, Cathryn] Univ Pompeu Fabra, Barcelona, Spain.
   [Mila, Carles; Ranzani, Otavio; Ambros, Albert; Kogevinas, Manolis; Dadvand, Payam; Tonne, Cathryn] CIBER Epidemiol & Salud Publ, Madrid, Spain.
   [Sanchez, Margaux] INSERM, Vieillissement & Malad Chron, Paris, France.
   [Bhogadi, Santhi] Publ Hlth Fdn India, New Delhi, India.
   [Kinra, Sanjay] London Sch Hyg & Trop Med, London, England.
C3 ISGlobal; Pompeu Fabra University; CIBER - Centro de Investigacion
   Biomedica en Red; CIBERESP; Institut National de la Sante et de la
   Recherche Medicale (Inserm); Public Health Foundation of India;
   University of London; London School of Hygiene & Tropical Medicine
RP Tonne, C (corresponding author), Univ Pompeu Fabra, ISGlobal, CIBER Epidemiol & Salud Publ, Doctor Aiguader 88, Barcelona 08003, Spain.
EM cathryn.tonne@isglobal.org
RI Kogevinas, Manolis/C-3918-2017; Ranzani, Otavio/K-1196-2012; Dadvand,
   Payam/O-8053-2018; Tonne, Cathryn/F-5020-2017
OI Tonne, Cathryn/0000-0003-3919-8264
FU European Research Council [336167]; Wellcome Trust [084674/Z]; Raman Y
   Cajal fellowship - Spanish Ministry of Economy and Competitiveness
   [RYC-2015-17402]; European Research Council (ERC) [336167] Funding
   Source: European Research Council (ERC)
FX We thank all participants of the Andhra Pradesh Children and Parent
   Study (APCAPS) and the Cardiovascular Health effects of Air pollution in
   Telangana, India (CHAT) study as well as all study teams involved in
   those projects. Landsat surface reflectance products were courtesy of
   the U.S. Geological Survey Earth Resources Observation and Science
   Center. We acknowledge past high-resolute imagery available in Google
   Earth. This work \vas supported by the European Research Council (grant
   agreement 336167 for the CHAI Project) and the Wellcome Trust (grant
   084674/Z for the third follow-up of the APCAPS). C.T. was funded through
   a Raman Y Cajal fellowship (RYC-2015-17402) awarded by the Spanish
   Ministry of Economy and Competitiveness. Data related to the APCAPS
   cohort is available to researchers through a brief application to the
   cohort's Steering Group (form available from APCAPS website,
   http://apcapsislitm.ac.uk, and submitted by email to apcaps@iiphh.org).
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NR 47
TC 15
Z9 17
U1 2
U2 16
PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE
PI RES TRIANGLE PK
PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233,
   RES TRIANGLE PK, NC 27709-2233 USA
SN 0091-6765
EI 1552-9924
J9 ENVIRON HEALTH PERSP
JI Environ. Health Perspect.
PD APR
PY 2020
VL 128
IS 4
AR 047003
DI 10.1289/EHP5445
PG 10
WC Environmental Sciences; Public, Environmental & Occupational Health;
   Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health; Toxicology
GA LX3PH
UT WOS:000539746400002
PM 32243204
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Dai, HJ
   Lu, SJ
   Tang, XH
   Lu, MG
   Chen, RF
   Chen, ZH
   Yang, PT
   Liu, C
   Zhou, HH
   Lu, Y
   Yuan, H
AF Dai, Haijiang
   Lu, Shijuan
   Tang, Xiaohong
   Lu, Minggen
   Chen, Ruifang
   Chen, Zhiheng
   Yang, Pingting
   Liu, Chang
   Zhou, Honghao
   Lu, Yao
   Yuan, Hong
TI Combined Association of Serum Uric Acid and Metabolic Syndrome with
   Chronic Kidney Disease in Hypertensive Patients
SO KIDNEY & BLOOD PRESSURE RESEARCH
LA English
DT Article
DE Serum uric acid; Hyperuricemia; Metabolic syndrome; Chronic kidney
   disease; Hypertension
ID OXIDATIVE STRESS; RISK; HYPERURICEMIA; ADULTS; CHINA
AB Background/Aims: Chronic kidney disease (CKD) is one of the major complications of hypertension. It is not only associated with the future burden of end-stage renal disease but also affects mortality and cardiovascular outcomes caused by hypertension. To help understand the pathogenesis and early prevention of progressive CKD, this large-scale study is designed to determine the complex association between serum uric acid (SUA), metabolic syndrome and the prevalence of CKD in hypertensive patients. Methods: A total of 19,848 hypertensive subjects were enrolled in this cross-sectional study. Patients with proteinuria and/or an estimated glomerular filtration rate (eGFR) of < 60 mL/min/1.73 m(2) were considered CKD cases. Results: Hypertensive subjects with CKD had a higher prevalence of hyperuricemia and metabolic syndrome, as well as higher levels of SUA, BMI, waist circumference (WC), SBP, DBP, TG, fasting blood glucose and lower levels of HDL-C. Compared to patients without CKD, the multivariate-adjusted odds ratios [ORs, 95% confidence interval (CI)] for CKD patients were 2.30 (2.02-2.63) for hyperuricemia, 1.21 (1.04-1.41) for abdominal obesity, 1.21 (1.06-1.38) for elevated TG, 1.29 (1.06-1.56) for low HDL-C, 1.54 (1.36-1.75) for elevated fasting glucose, and 1.49 (1.30-1.71) for metabolic syndrome. Increasing SUA levels and number of individual metabolic syndrome components were associated with an increased prevalence of CKD. Compared with patients classified in the lowest SUA categories and with <= 1 metabolic syndrome components, subjects with HUA and 4 metabolic syndrome components had a 5.77-fold increased OR for CKD based on the multivariate-adjusted analysis. Conclusion: Both elevated SUA and metabolic syndrome are associated with an increased prevalence of CKD in hypertensive subjects. Subjects with higher SUA and sum of individual metabolic syndrome components simultaneously have a higher prevalence of CKD. (C) 2016 The Author(s) Published by S. Karger AG, Basel
C1 [Dai, Haijiang; Tang, Xiaohong; Chen, Ruifang; Chen, Zhiheng; Yang, Pingting; Liu, Chang; Lu, Yao; Yuan, Hong] Cent South Univ, Xiangya Hosp 3, Changsha, Hunan, Peoples R China.
   [Lu, Shijuan; Zhou, Honghao] Cent South Univ, Inst Clin Pharmacol, Changsha, Hunan, Peoples R China.
   [Lu, Minggen] Univ Nevada, Sch Med, Reno, NV 89557 USA.
C3 Central South University; Central South University; Nevada System of
   Higher Education (NSHE); University of Nevada Reno
RP Lu, Y; Yuan, H (corresponding author), Cent South Univ, Ctr Clin Pharmacol, Xiangya Hosp 3, 138 Tong Zi Po Rd, Changsha 410013, Hunan, Peoples R China.
EM luyao0719@163.com; yuanhongxy3@163.com
RI Zhou, Honghao/JWO-4641-2024; Dai, Haijiang/GQH-2067-2022
OI Tang, Xiaohong/0000-0003-4240-3468
FU National Natural Science Foundation of China [81273594]; National Key
   Technology RD Program [2012BAI37B05]; Fundamental Research Funds for the
   Central Universities of Central South University [2016zzts153]
FX This research was supported by grants from the National Natural Science
   Foundation of China (No. 81273594), the National Key Technology R&D
   Program (No.2012BAI37B05), the Fundamental Research Funds for the
   Central Universities of Central South University (2016zzts153).
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NR 33
TC 23
Z9 26
U1 0
U2 14
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1420-4096
EI 1423-0143
J9 KIDNEY BLOOD PRESS R
JI Kidney Blood Pressure Res.
PY 2016
VL 41
IS 4
BP 413
EP 423
DI 10.1159/000443443
PG 11
WC Physiology; Urology & Nephrology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology; Urology & Nephrology; Cardiovascular System & Cardiology
GA DV2HB
UT WOS:000382740300007
PM 27355680
OA gold
DA 2025-06-11
ER

PT J
AU Papadopoulos, V
   Aghazadeh, Y
   Fan, JJ
   Campioli, E
   Zirkin, B
   Midzak, A
AF Papadopoulos, Vassilios
   Aghazadeh, Yasaman
   Fan, Jinjiang
   Campioli, Enrico
   Zirkin, Barry
   Midzak, Andrew
TI Translocator protein-mediated pharmacology of cholesterol transport and
   steroidogenesis
SO MOLECULAR AND CELLULAR ENDOCRINOLOGY
LA English
DT Article; Proceedings Paper
CT 16th Biennial Conference on the Adrenal Cortex (Adrenal)
CY JUN 17-20, 2014
CL Chicago, IL
SP Eunice Kennedy Shriver Natl Inst Child Hlth & Hum Dev, Natl Inst Hlth, Off Rare Dis, Univ Michigan Millie Schembechler Adrenal Canc Program, GWT TUD, Univ Buffalo, Dept Biochem
DE TSPO; Steroidogenesis; Pharmacology; Adrenal; Gonads; Brain
ID PERIPHERAL BENZODIAZEPINE-RECEPTOR; ACUTE REGULATORY PROTEIN; 18 KDA
   TSPO; DEPENDENT ANION CHANNEL; HORMONE-STIMULATED STEROIDOGENESIS;
   LEYDIG TUMOR-CELLS; EXTRACT EGB 761; STEROID-BIOSYNTHESIS;
   MITOCHONDRIAL-MEMBRANES; NEUROACTIVE STEROIDS
AB Steroidogenesis begins with cholesterol transfer into mitochondria through the transduceosome, a complex composed of cytosolic proteins that include steroidogenesis acute regulatory protein (STAR), 14-3-3 adaptor proteins, and the outer mitochondrial membrane proteins Translocator Protein (TSPO) and Voltage-Dependent Anion Channel (VDAC). TSPO is a drug- and cholesterol-binding protein found at particularly high levels in steroid synthesizing cells. Its aberrant expression has been linked to cancer, neurodegeneration, neuropsychiatric disorders and primary hypogonadism. Brain steroids serve as local regulators of neural development and excitability. Reduced levels of these steroids have been linked to depression, anxiety and neurodegeneration. Reduced serum testosterone is common among subfertile young men and aging men, and is associated with depression, metabolic syndrome and reduced sexual function. Although testosterone-replacement therapy is available, there are undesired side-effects. TSPO drug ligands have been proposed as therapeutic agents to regulate steroid levels in the brain and testis. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
C1 [Papadopoulos, Vassilios; Aghazadeh, Yasaman; Fan, Jinjiang; Campioli, Enrico; Midzak, Andrew] McGill Univ, Ctr Hlth, Res Inst, Montreal, PQ H4A 3J1, Canada.
   [Papadopoulos, Vassilios; Aghazadeh, Yasaman; Fan, Jinjiang; Campioli, Enrico] McGill Univ, Dept Med, Montreal, PQ H4A 3J1, Canada.
   [Papadopoulos, Vassilios] McGill Univ, Dept Pharmacol & Therapeut, Montreal, PQ H4A 3J1, Canada.
   [Papadopoulos, Vassilios; Midzak, Andrew] McGill Univ, Dept Biochem, Montreal, PQ H4A 3J1, Canada.
   [Zirkin, Barry] Johns Hopkins Univ, Dept Biochem & Mol Biol, Bloomberg Sch Publ Hlth, Baltimore, MD USA.
C3 McGill University; McGill University; McGill University; McGill
   University; Johns Hopkins University; Johns Hopkins Bloomberg School of
   Public Health
RP Papadopoulos, V (corresponding author), McGill Univ, Ctr Hlth, Res Inst, 1001 Decarie Blvd,Bloc E, Montreal, PQ H4A 3J1, Canada.
EM vassilios.papadopoulos@mcgill.ca
RI Papadopoulos, Vassilios/AAI-2613-2019; Fan, Jinjiang/C-2010-2009
OI Papadopoulos, Vassilios/0000-0002-1183-8568; Fan,
   Jinjiang/0000-0003-3102-4833
FU Canadian Institutes of Health Research [MOP 102647, MOP 125983] Funding
   Source: Medline; NIA NIH HHS [R37 AG021092, R01 AG021092, R21 AG051259,
   R37 AG21092] Funding Source: Medline
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NR 117
TC 103
Z9 107
U1 1
U2 15
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0303-7207
J9 MOL CELL ENDOCRINOL
JI Mol. Cell. Endocrinol.
PD JUN 15
PY 2015
VL 408
IS C
SI SI
BP 90
EP 98
DI 10.1016/j.mce.2015.03.014
PG 9
WC Cell Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Cell Biology; Endocrinology & Metabolism
GA CI8UT
UT WOS:000355047900013
PM 25818881
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Wu, CY
   Hu, HY
   Li, CP
   Chou, YJ
   Chang, YT
AF Wu, Chen-Yi
   Hu, Hsiao-Yun
   Li, Chung-Pin
   Chou, Yiing-Jeng
   Chang, Yun-Ting
TI Comorbidity profiles of psoriasis in Taiwan: A latent class analysis
SO PLOS ONE
LA English
DT Article
ID NUTRITION-EXAMINATION-SURVEY; POPULATION-BASED COHORT; FATTY
   LIVER-DISEASE; METABOLIC SYNDROME; NATIONAL-HEALTH; RISK; PREVALENCE;
   ASSOCIATION; DEPRESSION; ARTHRITIS
AB Background
   Psoriasis is associated with many comorbidities. An understanding of these comorbidity patterns can help foster better care of patients with psoriasis.
   Objective
   To identify the heterogeneity of psoriasis comorbidities using latent class analysis (LCA).
   Methods
   LCA was used to empirically identify psoriasis comorbidity patterns in a nationwide sample of 110,729 incident cases of psoriasis (2002-2012) from the National Health Insurance database in Taiwan.
   Results
   The mean age of incident psoriasis was 46.1 years. Hypertension (28.8%), dyslipidemia (18.9%), and chronic liver disease/cirrhosis/hepatitis (18.1%) were the top three comorbidities in patients with psoriasis. LCA identified four distinct comorbidity classes among these patients, including 9.9% of patients in the "multi-comorbidity" class, 17.9% in the "metabolic syndrome" class, 11.3% in the "hypertension and chronic obstructive pulmonary disease (COPD)" class, and 60.9% in the "relatively healthy" class. Psoriatic arthritis was evenly distributed among each class. Relative to membership in the "relative healthy" class, an increase of one year of age had a higher probability of membership in the "multi-comorbidity" (odds ratio [OR], 1.25), "metabolic syndrome" (OR, 1.11), or "hypertension and COPD" (OR, 1.34) classes. Relative to membership in the "relative healthy" class, compared to women, men had a higher probability of membership in the "multi-comorbidity" (OR, 1.39), "metabolic syndrome" (OR, 1.77), or "hypertension and COPD" (OR, 1.22) classes.
   Conclusion
   We observed four distinct classes of psoriasis comorbidities, including the "multi-comorbidity", "metabolic syndrome", "hypertension and COPD", and "relatively healthy" classes, as well as the clustering of liver diseases with metabolic syndrome and clustering of COPD with hypertension.
C1 [Wu, Chen-Yi; Chang, Yun-Ting] Taipei Vet Gen Hosp, Dept Dermatol, Taipei, Taiwan.
   [Wu, Chen-Yi; Hu, Hsiao-Yun; Chou, Yiing-Jeng] Natl Yang Ming Univ, Inst Publ Hlth, Taipei, Taiwan.
   [Wu, Chen-Yi; Hu, Hsiao-Yun; Chou, Yiing-Jeng] Natl Yang Ming Univ, Dept Publ Hlth, Taipei, Taiwan.
   [Wu, Chen-Yi; Chang, Yun-Ting] Natl Yang Ming Univ, Dept Dermatol, Taipei, Taiwan.
   [Hu, Hsiao-Yun] Taipei City Hosp, Dept Educ & Res, Taipei, Taiwan.
   [Li, Chung-Pin] Taipei Vet Gen Hosp, Dept Med, Div Gastroenterol & Hepatol, Taipei, Taiwan.
   [Li, Chung-Pin] Natl Yang Ming Univ, Sch Med, Taipei, Taiwan.
C3 Taipei Veterans General Hospital; National Yang Ming Chiao Tung
   University; National Yang Ming Chiao Tung University; National Yang Ming
   Chiao Tung University; Taipei City Hospital; Taipei Veterans General
   Hospital; National Yang Ming Chiao Tung University
RP Wu, CY (corresponding author), Taipei Vet Gen Hosp, Dept Dermatol, Taipei, Taiwan.; Wu, CY (corresponding author), Natl Yang Ming Univ, Inst Publ Hlth, Taipei, Taiwan.; Wu, CY (corresponding author), Natl Yang Ming Univ, Dept Publ Hlth, Taipei, Taiwan.; Wu, CY (corresponding author), Natl Yang Ming Univ, Dept Dermatol, Taipei, Taiwan.
EM chenyiok@gmail.com
RI Li, Chung-Pin/AHE-5783-2022
FU Ministry of Science and Technology [MOST 104-2314-6-075-044-MY2]
FX This work was supported by a grant from Ministry of Science and
   Technology (MOST 104-2314-6-075-044-MY2).
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NR 30
TC 23
Z9 23
U1 1
U2 6
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD FEB 6
PY 2018
VL 13
IS 2
AR e0192537
DI 10.1371/journal.pone.0192537
PG 10
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA FV1EC
UT WOS:000424302800079
PM 29408915
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Meksawan, K
   Sermsri, U
   Chanvorachote, P
AF Meksawan, Kulwara
   Sermsri, Urairat
   Chanvorachote, Pithi
TI Zinc Supplementation Improves Anticancer Activity of Monocytes in Type-2
   Diabetic Patients with Metabolic Syndrome
SO ANTICANCER RESEARCH
LA English
DT Article
DE Metabolic syndrome; monocyte; transmembrane TNF-alpha; type 2 diabetes;
   zinc
ID NECROSIS-FACTOR-ALPHA; TRANSMEMBRANE TNF-ALPHA; CYTOKINE SECRETION;
   IN-VITRO; ANTITUMOR; INSULIN; STRESS
AB Background: Transmembrane tumor necrosis factor (TNF)-alpha, found on monocytes, is a body's key defense against cancer. In patients with type 2 diabetes mellitus (DM) and metabolic syndrome, immunity is suppressed, resulting in a high risk of several inflammatory disorders and cancer. Patients and Methods: Seventeen patients with type 2 DM and metabolic syndrome were supplemented with either 30 mg of elemental zinc/day or placebo for eight weeks. Transmembrane TNF-alpha-expressing monocytes and lymphocytes, and plasma TNF-alpha levels were analyzed before and after supplementation. Results: The present study revealed that zinc supplementation significantly increased the proportion of monocytes expressing transmembrane TNF-alpha. While the plasma TNF-alpha levels and TNF-alpha expressing lymphocytes were not significantly altered in the zinc-treated and placebo groups, higher proportion of TNF-alpha bound monocytes were observed in the zinc-treated group. Conclusion: Because functional transmembrane TNF-alpha was shown to be implicated in defense mechanisms, these findings suggest that zinc supplementation may benefit immune response against cancer in patients with DM and metabolic syndrome.
C1 [Meksawan, Kulwara; Sermsri, Urairat] Chulalongkorn Univ, Dept Food & Pharmaceut Chem, Bangkok 10330, Thailand.
   [Chanvorachote, Pithi] Chulalongkorn Univ, Dept Physiol & Pharmacol, Fac Pharmaceut Sci, Bangkok 10330, Thailand.
   [Meksawan, Kulwara; Chanvorachote, Pithi] Chulalongkorn Univ, Cell Based Drug & Hlth Product Dev Res Unit, Bangkok 10330, Thailand.
C3 Chulalongkorn University; Chulalongkorn University; Chulalongkorn
   University
RP Chanvorachote, P (corresponding author), Chulalongkorn Univ, Dept Physiol & Pharmacol, Fac Pharmaceut Sci, Phyathai Rd, Bangkok 10330, Thailand.
EM pithi_chan@yahoo.com
OI chanvorachote, pithi/0000-0002-3103-3249
FU Pharmaceutical Research Instrument Center; Chulalongkorn University
   Centenary Academic Development Project, Faculty of Pharmaceutical
   Sciences, Chulalongkorn University
FX This work was conducted under the Cell-based Drug and Health Products
   Development Research Unit, Chulalongkorn University. We thank Mr. Krich
   Rajprasit, a proofreader and Ms. Phattrakorn Powan. The laboratory
   instruments used in this research were partly supported by the
   Pharmaceutical Research Instrument Center and the Chulalongkorn
   University Centenary Academic Development Project, Faculty of
   Pharmaceutical Sciences, Chulalongkorn University.
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NR 31
TC 17
Z9 18
U1 0
U2 0
PU INT INST ANTICANCER RESEARCH
PI ATHENS
PA EDITORIAL OFFICE 1ST KM KAPANDRITIOU-KALAMOU RD KAPANDRITI, PO BOX 22,
   ATHENS 19014, GREECE
SN 0250-7005
EI 1791-7530
J9 ANTICANCER RES
JI Anticancer Res.
PD JAN
PY 2014
VL 34
IS 1A
BP 295
EP 299
PG 5
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA 290NJ
UT WOS:000329765300038
PM 24403477
DA 2025-06-11
ER

PT J
AU Saini, K
   Sharma, S
   Bhatia, V
   Khan, Y
AF Saini, Kunika
   Sharma, Smriti
   Bhatia, Vinayak
   Khan, Yousuf
TI Dietary Polyphenolics: Mechanistic role in control management of
   Diabetes and Metabolic Syndrome
SO CHEMICAL BIOLOGY LETTERS
LA English
DT Article
DE polyphenols; diabetes; metabolic syndrome; antioxidants; obesity.
ID CARDIOVASCULAR RISK-FACTORS; GREEN TEA POLYPHENOLS; RED WINE
   POLYPHENOLS; VIRGIN OLIVE OIL; NF-KAPPA-B; OXIDATIVE STRESS;
   BLOOD-PRESSURE; INFLAMMATORY RESPONSES; INSULIN SENSITIVITY;
   PHENOLIC-COMPOUNDS
AB The search for an antidiabetic drug is going on three fronts: technological (for instance, development of an artificial pancreas), biological (such as pancreas and islet cell transplants), and pharmacological. Our review focusses on the role of polyphenolics in pharmacological research for T2DM. Being the most abundant antioxidants in human diets, dietary polyphenols have proven efficacy against a variety of diseases in both animal and human trials. Here, the authors present a review of advances in using polyphenols obtained from diet against diabetes and metabolic syndrome. Authors have discussed the role of polyphenols in disease management, and their sources. In addition to that, current knowledge of prevalent pathways of their action in cases of diabetes and metabolic syndrome have been discussed. The future directions and perspectives about diet polyphenols as a good alternative to first-line drug interventions have been included.
C1 [Saini, Kunika; Sharma, Smriti; Khan, Yousuf] Univ Delhi, Computat Chem Res Lab, Dept Chem, Miranda House, Delhi, India.
   [Bhatia, Vinayak] ICARE Eye Hosp & Postgrad Inst, Noida, India.
C3 University of Delhi
RP Sharma, S (corresponding author), Univ Delhi, Dept Chem, Miranda House, Delhi 110007, India.
EM smriti.chemistry@gmail.com
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NR 183
TC 2
Z9 2
U1 1
U2 1
PU ScienceIn Publications
PI Delhi
PA Main Gaddi Panna Raod, Jaunti, Delhi, North West Delhi, INDIA
EI 2347-9825
J9 CHEM BIOL LETT
JI Chem. Biol. Lett.
PY 2023
VL 10
IS 3
PG 16
WC Biochemistry & Molecular Biology; Chemistry, Medicinal
WE Emerging Sources Citation Index (ESCI)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
GA 9Y2UE
UT WOS:000950315000001
DA 2025-06-11
ER

PT J
AU Miao, RY
   Fang, XY
   Wei, JH
   Wu, HR
   Wang, XM
   Tian, JX
AF Miao, Runyu
   Fang, Xinyi
   Wei, Jiahua
   Wu, Haoran
   Wang, Xinmiao
   Tian, Jiaxing
TI Akt: A Potential Drug Target for Metabolic Syndrome
SO FRONTIERS IN PHYSIOLOGY
LA English
DT Review
DE Akt; insulin resistance; drug target; visceral adiposity; metabolic
   syndrome
ID TRANSCRIPTION FACTOR FOXO1; PROTEIN-KINASE B; INSULIN-RESISTANCE;
   DIABETES-MELLITUS; SKELETAL-MUSCLE; MICE LACKING; OBESITY;
   PHOSPHORYLATION; ACTIVATION; SENSITIVITY
AB The serine/threonine kinase Akt, also known as protein kinase B (PKB), is one of the key factors regulating glucose and lipid energy metabolism, and is the core focus of current research on diabetes and metabolic diseases. Akt is mostly expressed in key metabolism-related organs and it is activated in response to various stimuli, including cell stress, cell movement, and various hormones and drugs that affect cell metabolism. Genetic and pharmacological studies have shown that Akt is necessary to maintain the steady state of glucose and lipid metabolism and a variety of cellular responses. Existing evidence shows that metabolic syndrome is related to insulin resistance and lipid metabolism disorders. Based on a large number of studies on Akt-related pathways and reactions, we believe that Akt can be used as a potential drug target to effectively treat metabolic syndrome.
C1 [Miao, Runyu; Fang, Xinyi; Wang, Xinmiao; Tian, Jiaxing] China Acad Chinese Med Sci, Guanganmen Hosp, Dept Endocrinol, Beijing, Peoples R China.
   [Miao, Runyu; Fang, Xinyi; Wu, Haoran] Beijing Univ Chinese Med, Grad Coll, Beijing, Peoples R China.
   [Wei, Jiahua] Changchun Univ Chinese Med, Grad Coll, Changchun, Peoples R China.
C3 Guang'anmen Hospital, CACMS; China Academy of Chinese Medical Sciences;
   Beijing University of Chinese Medicine; Changchun University of Chinese
   Medicine
RP Tian, JX (corresponding author), China Acad Chinese Med Sci, Guanganmen Hosp, Dept Endocrinol, Beijing, Peoples R China.
EM tina_yai@126.com
RI Tian, Jiaxing/ITT-3407-2023
OI Wu, Haoran/0000-0003-2906-510X
FU National Natural Science Foundation of China [81904187]; Capital Health
   Development Research Project [CD2020-4-4155]; CACMS Innovation Fund
   [CI2021A01601]; CACMS Outstanding Young Scientific and Technological
   Talents Program [ZZ13-YQ-026]; Open Project of National Facility for
   Translational Medicine [TMSK-2021-407]; Innovation Team and Talents
   Cultivation Program of National Administration of Traditional Chinese
   Medicine [ZYYCXTD-D-202001]
FX This work was supported by the National Natural Science Foundation of
   China (No. 81904187), Capital Health Development Research Project
   (CD2020-4-4155), CACMS Innovation Fund (CI2021A01601), CACMS Outstanding
   Young Scientific and Technological Talents Program (ZZ13-YQ-026), Open
   Project of National Facility for Translational Medicine (TMSK-2021-407),
   and Innovation Team and Talents Cultivation Program of National
   Administration of Traditional Chinese Medicine (No. ZYYCXTD-D-202001).
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U1 2
U2 28
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1664-042X
J9 FRONT PHYSIOL
JI Front. Physiol.
PD MAR 7
PY 2022
VL 13
AR 822333
DI 10.3389/fphys.2022.822333
PG 10
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA 0G0DZ
UT WOS:000777726400001
PM 35330934
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Yilmaz, SK
   Eskici, G
   Mertoglu, C
   Ayaz, A
AF Yilmaz, Sevil Karahan
   Eskici, Gunay
   Mertoglu, Cuma
   Ayaz, Aylin
TI Adipokines, inflammation, oxidative stress: critical components in obese
   women with metabolic syndrome
SO PROGRESS IN NUTRITION
LA English
DT Article
DE Obesity; metabolic syndrome; adipokines; inflammation; oxidative stress
AB Objective: Adipose tissue dysfunction, increased systemic inflammation and oxidative stress are features of metabolic syndrome. The purpose of the present study was to determine the relationship between adipokines, inflammation, oxidative stress and metabolic syndrome components in obese women. Subjects and Methods: A total sample of 100 obese women (BMI=32.44 +/- 1.80 kg/m(2)) living in Erzincan aged 20-45 years were included in this cross-sectional survey. Serum biochemical (leptin, adiponectin, resistin, lipit profiles, fasting plasma glucose, fasting plasma insulin, high sensitivity C-reactive protein, tumor necrosis factor-alfa, interleukin-6, malondialdehyde, anthropometrical (body weight, height, waist and neck circumference) parameters and blood pressure were measured. Metabolic syndrome was defined according to National Cholesterol Education Program Adult Treatment Panel-III (NCEP-ATP III) criteria. Results: Results of this study indicate that waist circumference, neck circumference, systolic blood pressure (SBP), diastolic blood pressure (DBP), fasting plasma insulin (FPI), HOMA-IR, triglyceride (TG), high sensitivity C-reactive protein (HsCRP), Tumor Necrosis Factor -alfa (TNF-alpha), leptin, leptin: adiponectin (L:A) ratio and malondialdehyde (MAD) were significantly higher but adiponectin and HDL-Cholesterol (HDL-C) were significantly lower in obese women with metabolic syndrome than in women without the syndrome (p <0.05). Waist circumference had positive correlation with Hs-CRP (r = 0.315, p < 0.05) and negative correlation with adiponectin (r =- 0.552, p < 0.01). TG had highly significant positive correlation with Hs-CRP (r = 0.305, p < 0.05) but, negative correlation with IL-6 (r = -0.347, p < 0.05) and adiponectin (r=-0.440, p< 0.01). Hs-CRP was positively correlated with MDA (r=0.323, p< 0.05) and negatively correlated with DBP (r=-0.253, p< 0.05). TNF-alpha was significantly and positively correlated with leptin (r = 0.701, p < 0.01), resistin (r = 0.646, p < 0.01), MDA (r = 0.949, p < 0.01) and negatively correlated with adiponectin (r =-0.772, p < 0.01). MDA had positive correlation with TNF-alpha (r = 0.949, p <0.01), leptin (r = 0.721, p < 0.01), adiponectin (r = 0.788, p< 0.01) and resistin (r = 0.694, p < 0.01). Hs-CRP was significantly and positively associated with waist circumferemce (beta = 0.315, p < 0.05), TG (beta = 0.307, p < 0.05) and negatively associated with DBP (beta = -0.276, p < 0.05). Conclusion: High leptin and low adiponectin level, L:A ratio, Hs-CRP, TNF-alpha and MDA may act as a diagnostic marker for metabolic syndrome in obese women.
C1 [Yilmaz, Sevil Karahan] Erzincan Binali Yildirim Univ, Fac Hlth Sci, Dept Nutr & Dietet, Erzincan, Turkey.
   [Eskici, Gunay] Canaldcale Onsekiz Mart Univ, Fac Sport Sci, Dept Coaching, Canakkale, Turkey.
   [Mertoglu, Cuma] Erzincan Binali Yildirim Univ, Fac Med, Dept Clin Biochem, Erzincan, Erzincan, Turkey.
   [Ayaz, Aylin] Hacettepe Univ, Fac Hlth Sci, Dept Nutr & Dietet, Ankara, Turkey.
C3 Erzincan Binali Yildirim University; Erzincan Binali Yildirim
   University; Hacettepe University
RP Yilmaz, SK (corresponding author), Erzincan Binali Yildirim Univ, Fac Hlth Sci, Dept Nutr & Dietet, Erzincan, Turkey.
EM karahany.sevil12@gmail.com
RI KARAHAN YILMAZ, SEVİL/JEF-6427-2023; Mertoglu, Cuma/A-3506-2017
FU Erzincan University.B.A.B [TSA-2016-354]
FX This research supported by Erzincan University.B.A.B. (TSA-2016-354).
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NR 53
TC 0
Z9 0
U1 0
U2 7
PU MATTIOLI 1885
PI FIDENZA
PA VIA DELLA LODESANA 649-SX, FIDENZA, 43046 PR, ITALY
SN 1129-8723
J9 PROG NUTR
JI Prog. Nutr.
PD MAR
PY 2021
VL 23
IS 1
AR e2021009
DI 10.23751/pn.v23i1.9072
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA RI3CE
UT WOS:000636784700030
DA 2025-06-11
ER

PT J
AU Dakic, T
   Lakic, I
   Zec, M
   Takic, M
   Stojiljkovic, M
   Jevdjovic, T
AF Dakic, Tamara
   Lakic, Iva
   Zec, Manja
   Takic, Marija
   Stojiljkovic, Mojca
   Jevdjovic, Tanja
TI Fructose-rich diet and walnut supplementation differently regulate rat
   hypothalamic and hippocampal glucose transporters expression
SO JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
LA English
DT Article
DE fructose; hippocampus; hypothalamus; glucose transporters; walnut
ID METABOLIC SYNDROME; FATTY-ACIDS; CONSUMPTION; OBESITY; CELLS;
   NEUROGENESIS; INFLAMMATION; RESISTANCE; PROFILE; STRESS
AB BACKGROUND Nutritional modulations may be considered a strategy to protect mental health. Neuronal homeostasis is highly dependent on the availability of glucose, which represents the primary energy source for the brain. In this study, we evaluated the effects of walnut intake and fructose-rich diet on the expression of glucose transporters (GLUTs) in two rat brain regions: hypothalamus and hippocampus.
   RESULTS Our results show that walnut supplementation of fructose-fed animals restored the hypothalamic content of GLUT1 and GLUT3 protein. Furthermore, walnut intake did not affect increased hypothalamic GLUT2 content upon fructose consumption. These effects were accompanied by distinctive alterations of hippocampal GLUTs levels. Specifically, walnut intake increased GLUT1 content, whereas GLUT2 protein was decreased within the rat hippocampus after both individual and combined treatments.
   CONCLUSION Overall, our study suggests that walnut supplementation exerted modulatory effects on the glucose transporters within specific brain regions in the presence of developed metabolic disorder. (c) 2021 Society of Chemical Industry.
C1 [Dakic, Tamara; Lakic, Iva; Jevdjovic, Tanja] Univ Belgrade, Inst Physiol & Biochem Ivan Djaja, Dept Comparat Physiol & Ecophysiol, Fac Biol, Belgrade 11000, Serbia.
   [Zec, Manja; Takic, Marija] Univ Belgrade, Inst Med Res, Natl Inst Republ Serbia, Ctr Excellence Nutr & Metab Res, Belgrade, Serbia.
   [Stojiljkovic, Mojca] Univ Belgrade, Natl Inst Republ Serbia, Vinca Inst Nucl Sci, Dept Mol Biol & Endocrinol, Belgrade, Serbia.
C3 University of Belgrade; University of Belgrade; University of Belgrade
RP Jevdjovic, T (corresponding author), Univ Belgrade, Inst Physiol & Biochem Ivan Djaja, Dept Comparat Physiol & Ecophysiol, Fac Biol, Belgrade 11000, Serbia.
EM tanja.jevdjovic@bio.bg.ac.rs
RI ; Zec, Manja/T-5942-2019
OI Dakic, Tamara/0000-0002-7238-2728; Zec, Manja/0000-0001-5283-9295;
   Stojiljkovic, Mojca/0000-0002-9041-7947
FU Ministry of Education, Science and Technological Development of the
   Republic of Serbia [451-03-68/2020-14/200178, 451-03-68/2020-14/200015,
   451-03-68/2020-14/200017]
FX We thank our colleagues Dr Goran Koricanac and Dr Predrag Vujovic for
   their constructive criticism. This work was supported by the Ministry of
   Education, Science and Technological Development of the Republic of
   Serbia, under the contract numbers 451-03-68/2020-14/200178,
   451-03-68/2020-14/200015 and 451-03-68/2020-14/200017.
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NR 54
TC 1
Z9 1
U1 0
U2 12
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-5142
EI 1097-0010
J9 J SCI FOOD AGR
JI J. Sci. Food Agric.
PD NOV
PY 2021
VL 101
IS 14
BP 5984
EP 5991
DI 10.1002/jsfa.11252
EA APR 2021
PG 8
WC Agriculture, Multidisciplinary; Chemistry, Applied; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture; Chemistry; Food Science & Technology
GA WC0KA
UT WOS:000644854300001
PM 33856052
DA 2025-06-11
ER

PT J
AU Ullah, H
   De Filippis, A
   Khan, H
   Xiao, JB
   Daglia, M
AF Ullah, Hammad
   De Filippis, Anna
   Khan, Haroon
   Xiao, Jianbo
   Daglia, Maria
TI An overview of the health benefits of Prunus species with special
   reference to metabolic syndrome risk factors
SO FOOD AND CHEMICAL TOXICOLOGY
LA English
DT Article
DE Genus Prunus; Insulin resistance; Obesity; Metabolic syndrome;
   Alternative therapies
ID DIABETES-MELLITUS; ETHNOPHARMACOLOGICAL SURVEY; INSULIN-RESISTANCE;
   ENDOTHELIAL DYSFUNCTION; CHRONIC COMPLICATIONS; ANTIOXIDANT ACTIVITY;
   ADIPOSE-TISSUE; HYPERTENSION; EXTRACT; OBESITY
AB Metabolic syndrome is a cluster of pathologies and conditions such as obesity, hyperglycemia, hyperlipidemia and hypertension representing a serious health concern in many countries due to its high rate of mortality and morbidity. Insulin resistance is known to play a central role in the development of metabolic syndrome and several risk factors, including visceral obesity, oxidative stress and chronic inflammation, could trigger insulin resistance. Different strategies are currently in practice to manage metabolic syndrome. Along with dietary components, botanicals contain secondary metabolites, which may play a pivotal role in the maintenance of health by combating chronic disorders. Genus Prunus is classified under family Rosaceae and consists of 400-430 species. This genus contains some important species of fruits and ornamental plants. Prunus species contain important micronutrients such as vitamins and minerals and their consumption could maintain health by nourishing the body with essential and non-essential compounds. Besides nutritional components, they also contain bioactive compounds such as polyphenols, which make them potential alternative therapeutic agents for a number of chronic disorders including dysregulated metabolic conditions. The present review is designed to highlight the evidence-based effects of Prunus species against metabolic syndrome risk factors.
C1 [Ullah, Hammad; De Filippis, Anna; Daglia, Maria] Univ Naples Federico II, Dept Pharm, Naples, Italy.
   [Khan, Haroon] Abdul Wali Khan Univ, Dept Pharm, Mardan 23200, Pakistan.
   [Xiao, Jianbo; Daglia, Maria] Jiangsu Univ, Int Res Ctr Food Nutr & Safety, Zhenjiang 212013, Jiangsu, Peoples R China.
C3 University of Naples Federico II; Abdul Wali Khan University; Jiangsu
   University
RP Daglia, M (corresponding author), Univ Naples Federico II, Dept Pharm, Naples, Italy.
EM maria.daglia@unina.it
RI Ullah, Hammad/AAF-1802-2019; Khan, Prof. Dr. Haroon/AAY-1785-2020;
   Daglia, Maria/AAC-9498-2019; De Filippis, Anna/AAT-2038-2020; Xiao,
   Jianbo/C-7323-2012; DE FILIPPIS, ANNA/HZK-3236-2023
OI Daglia, Maria/0000-0002-4870-7713; Ullah, Hammad/0000-0003-0668-8806; DE
   FILIPPIS, ANNA/0000-0002-0395-7962; Ullah, Hammad/0000-0001-9437-676X
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NR 133
TC 25
Z9 27
U1 1
U2 14
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0278-6915
EI 1873-6351
J9 FOOD CHEM TOXICOL
JI Food Chem. Toxicol.
PD OCT
PY 2020
VL 144
AR 111574
DI 10.1016/j.fct.2020.111574
PG 12
WC Food Science & Technology; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Toxicology
GA NK6AX
UT WOS:000566815000008
PM 32679287
DA 2025-06-11
ER

PT J
AU Hjellset, VT
   Ihlebæk, CM
   Bjorge, B
   Eriksen, HR
   Hostmark, AT
AF Hjellset, Victoria Telle
   Ihlebaek, Camilla M.
   Bjorge, Benedikte
   Eriksen, Hege R.
   Hostmark, Arne T.
TI Health-Related Quality of Life, Subjective Health Complaints,
   Psychological Distress and Coping in Pakistani Immigrant Women With and
   Without the Metabolic Syndrome
SO JOURNAL OF IMMIGRANT AND MINORITY HEALTH
LA English
DT Article
DE Pakistani immigrant women; Immigration; Psychological distress; Coping;
   Metabolic syndrome
ID COGNITIVE ACTIVATION THEORY; RHEUMATOID-ARTHRITIS; ETHNIC-DIFFERENCES;
   MENTAL-HEALTH; OSLO; PREVALENCE; SF-36; DISEASE; RELIABILITY;
   PERFORMANCE
AB The increasingly high number of immigrants from South-East Asia with The Metabolic Syndrome (MetS) is an important challenge for the public health sector. Impaired glucose is essential in MetS. The blood glucose concentration is not only governed by diet and physical activity, but also by psychological distress which could contribute to the development of MetS. The aim of this study is to describe health-related quality of life, subjective health complaints (SHC), psychological distress, and coping in Pakistani immigrant women, with and without MetS. As a part of an randomized controlled intervention study in Oslo, Norway, female Pakistani immigrants (n = 198) answered questionnaires regarding health related quality of life, SHC, psychological distress, and coping. Blood variables were determined and a standardized oral glucose tolerance test was performed. The participants had a high score on SHC and psychological distress. About 40% of the participants had MetS, and this group showed significantly lower general health, lower physical function, and more bodily pain, than those without MetS. Those with MetS also had more SHC, depressive symptoms, higher levels of somatisation, and scored significantly lower on the coping strategy of active problem solving. Pakistani immigrant women seem to have a high prevalence of SHC and psychological distress, especially those with MetS.
C1 [Hjellset, Victoria Telle; Hostmark, Arne T.] Univ Oslo, Inst Gen Practice & Community Med, N-0318 Oslo, Norway.
   [Eriksen, Hege R.] Univ Bergen, Fac Psychol, Bergen, Norway.
   [Ihlebaek, Camilla M.] Univ Life Sci UMB, Res Grp Nat Hlth & Qual Life, IHA, As, Norway.
   [Bjorge, Benedikte] Univ Oslo, Dept Nutr, N-0318 Oslo, Norway.
C3 University of Oslo; University of Bergen; Norwegian University of Life
   Sciences; University of Oslo
RP Hjellset, VT (corresponding author), Univ Oslo, Inst Gen Practice & Community Med, Box 1130, N-0318 Oslo, Norway.
EM v.t.hjellset@medisin.uio.no
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NR 55
TC 16
Z9 17
U1 1
U2 16
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1557-1912
EI 1557-1920
J9 J IMMIGR MINOR HEALT
JI J. Immigr. Minor. Health
PD AUG
PY 2011
VL 13
IS 4
BP 732
EP 741
DI 10.1007/s10903-010-9409-6
PG 10
WC Public, Environmental & Occupational Health
WE Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA 789YM
UT WOS:000292555500013
PM 21061066
OA Green Accepted, Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Hsu, WY
   Tsai, HJ
   Yu, SH
   Hsu, CC
   Tsai, YT
   Tzeng, HY
   Lin, IC
   Liu, K
   Lee, MM
   Chiu, NY
   Hsiung, CA
AF Hsu, Wen-Yu
   Tsai, Hui-Ju
   Yu, Shu-Han
   Hsu, Chih-Cheng
   Tsai, Yu-Ting
   Tzeng, Han-Yun
   Lin, I-Ching
   Liu, Kiang
   Lee, Marion M.
   Chiu, Nan-Ying
   Hsiung, Chao A.
TI Association of depression and psychotropic medication on cardiac-related
   outcomes in a nationwide community-dwelling elderly population in Taiwan
SO MEDICINE
LA English
DT Article
DE cardiovascular disease; community; depression; older; psychotropic
   medication
ID CORONARY-HEART-DISEASE; CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME;
   ANXIETY DISORDERS; RATE-VARIABILITY; GLOBAL BURDEN; RISK; MORTALITY;
   SCHIZOPHRENIA; SYMPTOMS
AB The objective of this study was to examine the association of depression, psychotropic medications, and mental illness with cardiovascular disease in a nationwide community-dwelling elderly population in Taiwan. A total of 5664 participants who enrolled in the Healthy Aging Longitudinal Study in Taiwan (HALST) were included in the study. Multiple logistic regression was applied to investigate the association of depression, psychotropic medication use, and mental illness, separately, with cardiovascular disease. The results suggested that cardiovascular disease was significantly associated with various definitions of depression, including: the Center for Epidemiologic Studies-Depression scale (CES-D) >= 16, self-reported, and physician-diagnosed for depression (adjusted odds ratio [AOR] = 1.51; 95% confidence interval (CI): 1.14-2.00 for CES-D; AOR = 3.29; 95% CI: 1.99-5.42 for self-reported; and AOR = 2.45; 95% CI: 1.51-3.97 for physician-diagnosed). Additionally, significant associations of cardiovascular disease with the use of antipsychotics (AOR = 2.04; 95% CI: 1.25-3.34), benzodiazepines (BZDs) (AOR = 1.84; 95% CI: 1.52-2.21), and Z-drugs (AOR = 1.41; 95% CI: 1.03-1.93), respectively, were also observed, but not the use of antidepressants. In addition, a significant association of cardiovascular disease with mental illness was found in this study (AOR = 2.33; 95% CI: 1.68-3.24). In line with previous reports, these findings provided supportive evidence that depression and/or mental illness were significantly associated with cardiovascular disease in a community-dwelling elderly population in Taiwan. Moreover, significant associations of cardiovascular disease with the use of antipsychotics, BZDs, and Z-drugs, individually, were found. Further investigation would be of importance to clarify the causal relationship of depression and/or psychotropic medications with cardiovascular disease, especially among elderly populations.
C1 [Hsu, Wen-Yu; Chiu, Nan-Ying] Changhua Christian Hosp, Dept Psychiat, Changhua, Taiwan.
   [Hsu, Wen-Yu; Chiu, Nan-Ying] Lu Tung Christian Hosp, Dept Psychiat, Lukang, Taiwan.
   [Hsu, Wen-Yu; Lin, I-Ching; Chiu, Nan-Ying] Chung Shan Med Univ, Sch Med, Taichung, Taiwan.
   [Hsu, Wen-Yu] China Med Univ, Inst Clin Med Sci, Taichung, Taiwan.
   [Hsu, Wen-Yu; Lin, I-Ching; Chiu, Nan-Ying] Changhua Christian Hosp, Ctr Aging & Hlth, Changhua, Taiwan.
   [Tsai, Hui-Ju; Hsu, Chih-Cheng; Tsai, Yu-Ting; Tzeng, Han-Yun; Hsiung, Chao A.] Natl Hlth Res Inst, Inst Populat Hlth Sci, Miaoli, Taiwan.
   [Tsai, Hui-Ju] Northwestern Univ, Dept Pediat, Feinberg Sch Med, Chicago, IL 60611 USA.
   [Tsai, Hui-Ju] China Med Univ, Dept Publ Hlth, Taichung, Taiwan.
   [Yu, Shu-Han] Chung Shan Med Univ Hosp, Aesthetic Mind Clin, Taichung, Taiwan.
   [Yu, Shu-Han] Chung Shan Med Univ Hosp, Dept Psychiat, Taichung, Taiwan.
   [Lin, I-Ching] Changhua Christian Hosp, Dept Family Med, Changhua, Taiwan.
   [Lin, I-Ching] Asia Univ, Dept Healthcare Adm, Taichung, Taiwan.
   [Liu, Kiang] Northwestern Univ, Feinberg Sch Med, Dept Prevent Med, Chicago, IL 60611 USA.
   [Lee, Marion M.] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA.
C3 Changhua Christian Hospital; Chung Shan Medical University; China
   Medical University Taiwan; Changhua Christian Hospital; National Health
   Research Institutes - Taiwan; Northwestern University; Feinberg School
   of Medicine; China Medical University Taiwan; Chung Shan Medical
   University; Chung Shan Medical University Hospital; Chung Shan Medical
   University; Chung Shan Medical University Hospital; Changhua Christian
   Hospital; Asia University Taiwan; Northwestern University; Feinberg
   School of Medicine; University of California System; University of
   California San Francisco
RP Hsiung, CA (corresponding author), Natl Hlth Res Inst, Inst Populat Hlth Sci, Div Biostat & Bioinformat, Miaoli 350, Taiwan.; Chiu, NY (corresponding author), Lu Tung Christian Hosp, Dept Psychiat, 888 Lu Tung Rd, Changhua, Taiwan.
EM 400786@cch.org.tw; hsiung@nhri.org.tw
RI LIN, HUI-CHEN/AAA-8973-2021; Tsai, Hui-Ju/E-3937-2010; Hsu,
   Chih-Cheng/E-3849-2010
FU National Health Research Institutes in Taiwan [BS-097-SP-04,
   PH-098-SP-02, PH-099-SP-01, PH-100-SP-01, PH-101-SP-01]
FX This study was supported by the National Health Research Institutes in
   Taiwan (Project no. BS-097-SP-04, PH-098-SP-02, PH-099-SP-01,
   PH-100-SP-01, and PH-101-SP-01). The sponsor had no role in the design
   and conduct of the study; collection, management, analysis, and
   interpretation of the data; and preparation, review, or approval of the
   manuscript.
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NR 40
TC 2
Z9 3
U1 1
U2 7
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD AUG
PY 2016
VL 95
IS 31
AR e4419
DI 10.1097/MD.0000000000004419
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA DS4ZI
UT WOS:000380789800047
PM 27495061
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Ottomana, AM
   Presta, M
   O'Leary, A
   Sullivan, M
   Pisa, E
   Laviola, G
   Glennon, JC
   Zoratto, F
   Slattery, DA
   Macrì, S
AF Ottomana, Angela Maria
   Presta, Martina
   O'Leary, Aet
   Sullivan, Mairead
   Pisa, Edoardo
   Laviola, Giovanni
   Glennon, Jeffrey C.
   Zoratto, Francesca
   Slattery, David A.
   Macri, Simone
TI A systematic review of preclinical studies exploring the role of insulin
   signalling in executive function and memory
SO NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
LA English
DT Review
DE Insulin signalling; Mental health; Comorbidity; Animal models;
   Systematic review
ID ALLEVIATES COGNITION DEFICITS; DIABETES-MELLITUS; SPATIAL MEMORY;
   ALZHEIMERS-DISEASE; ANIMAL-MODELS; HIPPOCAMPAL NEUROGENESIS; CLINICAL
   PRESENTATION; GLUCOSE REGULATION; METABOLIC SYNDROME; OXIDATIVE STRESS
AB Beside its involvement in somatic dysfunctions, altered insulin signalling constitutes a risk factor for the development of mental disorders like Alzheimer's disease and obsessive-compulsive disorder. While insulin-related somatic and mental disorders are often comorbid, the fundamental mechanisms underlying this associ-ation are still elusive. Studies conducted in rodent models appear well suited to help decipher these mechanisms. Specifically, these models are apt to prospective studies in which causative mechanisms can be manipulated via multiple tools (e.g., genetically engineered models and environmental interventions), and experimentally dissociated to control for potential confounding factors. Here, we provide a narrative synthesis of preclinical studies investigating the association between hyperglycaemia - as a proxy of insulin-related metabolic dysfunctions - and impairments in working and spatial memory, and attention. Ultimately, this review will advance our knowledge on the role of glucose metabolism in the comorbidity between somatic and mental illnesses.
C1 [Ottomana, Angela Maria; Presta, Martina; Pisa, Edoardo; Laviola, Giovanni; Zoratto, Francesca; Macri, Simone] Ist Super Sanita, Ctr Behav Sci & Mental Hlth, I-00161 Rome, Italy.
   [Ottomana, Angela Maria] Univ Parma, Dept Med, Neurosci Unit, I-43100 Parma, Italy.
   [Presta, Martina] Sapienza Univ Rome, Dept Physiol & Pharmacol, I-00185 Rome, Italy.
   [O'Leary, Aet; Slattery, David A.] Univ Hosp Frankfurt, Dept Psychiat Psychosomat Med & Psychotherapy, Frankfurt, Germany.
   [O'Leary, Aet] Univ Tartu, Inst Chem, Chair Neuropsychopharmacol, Tartu, Estonia.
   [Sullivan, Mairead; Glennon, Jeffrey C.] Univ Coll Dublin, Conway Inst Biomol & Biomed Res, Dublin, Ireland.
C3 Istituto Superiore di Sanita (ISS); University of Parma; Sapienza
   University Rome; Goethe University Frankfurt; Goethe University
   Frankfurt Hospital; University of Tartu; University College Dublin
RP Macrì, S (corresponding author), Ist Super Sanita, Ctr Behav Sci & Mental Hlth, I-00161 Rome, Italy.
RI Laviola, Giovanni/K-4392-2016; Slattery, David/AAJ-1740-2020; Zoratto,
   Francesca/K-6031-2016; Ottomana, Angela/IAO-1468-2023
OI Glennon, Jeffrey/0000-0002-2371-0422; Zoratto,
   Francesca/0000-0002-3626-8928; PISA, EDOARDO/0000-0002-3243-8432;
   O'Leary, Aet/0000-0001-6783-4729; Slattery, David/0000-0001-8753-5005;
   Ottomana, Angela/0000-0002-2163-7575; Macri, Simone/0000-0003-2946-4784;
   Presta, Martina/0009-0005-7768-8768
FU European Union [847879]; Regione Lazio [G08487]
FX This project has received funding from the European Union's Horizon 2020
   research and innovation programme under grant agreement No 847879 (to
   SM, DS, AOL and JG) and from Regione Lazio (grant agreement POR FESR
   Lazio 2014-2020, ID code G08487 to SM) .
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NR 207
TC 5
Z9 5
U1 3
U2 7
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0149-7634
EI 1873-7528
J9 NEUROSCI BIOBEHAV R
JI Neurosci. Biobehav. Rev.
PD DEC
PY 2023
VL 155
AR 105435
DI 10.1016/j.neubiorev.2023.105435
EA NOV 2023
PG 32
WC Behavioral Sciences; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Behavioral Sciences; Neurosciences & Neurology
GA Z5QD2
UT WOS:001112609400001
PM 37913873
OA hybrid
DA 2025-06-11
ER

PT J
AU Chang, JC
   Yen, AMF
   Lee, CS
   Chen, SLS
   Chiu, SYH
   Fann, JCY
   Chen, HH
AF Chang, Jung-Chen
   Yen, Amy Ming-Fang
   Lee, Chau-Shoun
   Chen, Sam Li-Sheng
   Chiu, Sherry Yueh-Hsia
   Fann, Jean Ching-Yuan
   Chen, Hsiu-Hsi
TI Metabolic Syndrome and the Risk of Suicide: A Community-Based Integrated
   Screening Samples Cohort Study
SO PSYCHOSOMATIC MEDICINE
LA English
DT Article
DE metabolic syndrome; suicide; mood disorders; blood pressure;
   hypertension; community-based integrated screening samples
ID DEPRESSIVE SYMPTOMS; CARDIOVASCULAR-DISEASE; INFORMATION-SYSTEM;
   SERUM-CHOLESTEROL; BIPOLAR-DISORDER; FOLLOW-UP; ASSOCIATION; KEELUNG;
   HEALTH; DEATH
AB Objective: Metabolic syndrome (MetS) is reportedly associated with mental disorders that are known to increase the risk of suicide. However, it is not known whether this association is independent of other risk indicators of suicide. This study therefore investigated whether metabolic abnormalities increase the risk of suicide during a 10-year follow-up period. Methods: This prospective study enrolled participants from a community-based integrated screening samples cohort in Taiwan. Of the 76,297 people recruited for this study, 12,094 had MetS at baseline. The independent variables were MetS and its components such as high blood pressure and high blood lipid levels. The outcome was death from suicide (n = 146). Results: MetS was associated with an increased risk of suicide risk by 16% per MetS component (95% confidence interval [CI] = 1%-33%), adjusting for demographics, life-style factors, and clinical correlates. Of the five MetS components, elevated blood pressure was independently associated with suicide-related mortality (adjusted hazard ratio [aHR] = 1.49, 95% CI = 1.03-2.15). Conclusions: This analysis of community-based longitudinal data showed that MetS and its components, particularly elevated blood pressure, correlated positively with suicide risk after controlling other factors. Therefore, public mental health interventions targeting suicide reduction may need to specifically focus on individuals with hypertension and other components of the MetS.
C1 [Chang, Jung-Chen] Natl Taiwan Univ, Coll Med, Taipei 10051, Taiwan.
   [Chen, Hsiu-Hsi] Natl Taiwan Univ, Coll Publ Hlth, Grad Inst Epidemiol & Prevent Med, Div Biostat, Taipei 10051, Taiwan.
   [Chang, Jung-Chen] Natl Taiwan Univ Hosp, Taipei, Taiwan.
   [Yen, Amy Ming-Fang; Chen, Sam Li-Sheng] Taipei Med Univ, Sch Oral Hyg, Coll Oral Med, Taipei, Taiwan.
   [Lee, Chau-Shoun] Mackay Mem Hosp, Dept Psychiat, Taipei, Taiwan.
   [Fann, Jean Ching-Yuan] Kainan Univ, Dept Hlth Ind Management, Luzhu Township, Taoyuan County, Taiwan.
   [Lee, Chau-Shoun] Kainan Univ, Coll Healthcare Management, Luzhu Township, Taoyuan County, Taiwan.
   [Chiu, Sherry Yueh-Hsia] Chang Gung Univ, Coll Management, Dept Hlth Care Management, Tao Yuan, Taiwan.
C3 National Taiwan University; National Taiwan University; National Taiwan
   University; National Taiwan University Hospital; Taipei Medical
   University; Mackay Memorial Hospital; Nan Kai University Technology; Nan
   Kai University Technology; Chang Gung University
RP Chang, JC (corresponding author), Natl Taiwan Univ, Coll Med, Dept Nursing, 1 Jen Rd Sec 1, Taipei 10051, Taiwan.
EM jungchenchang@ntu.edu.tw
RI Hsu, Chien-Ning/GLS-4014-2022; Chen, Jung-Chien/W-1862-2019
OI Chiu, Sherry Yueh-Hsia/0000-0002-7207-7088; CHANG,
   JUNG-CHEN/0000-0001-8651-2602; Chen, Tony Hsiu-Hsi/0000-0002-5799-6705
FU National Science Council, Executive Yuan, Republic of Taiwan
FX This study led by Professor Hsiu-Hsi Chen was funded by National Science
   Council, Executive Yuan, Republic of Taiwan. The National Science
   Council had no role in the design of the study, the collection,
   analysis, and intopretation of data, the writing of the repo, 1, or the
   decision to submit the manuscript for publication. None of the authors
   received outside support fin the current study No authors have conflicts
   of interest in the publication of this manuscript.
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NR 67
TC 22
Z9 22
U1 0
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0033-3174
EI 1534-7796
J9 PSYCHOSOM MED
JI Psychosom. Med.
PD NOV-DEC
PY 2013
VL 75
IS 9
BP 807
EP 814
DI 10.1097/PSY.0000000000000014
PG 8
WC Psychiatry; Psychology; Psychology, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry; Psychology
GA 300NB
UT WOS:000330469500002
PM 24163389
DA 2025-06-11
ER

PT J
AU Gottlieb, AB
   Dann, F
AF Gottlieb, Alice B.
   Dann, Frank
TI Comorbidities in Patients with Psoriasis
SO AMERICAN JOURNAL OF MEDICINE
LA English
DT Review
DE Cardiovascular disease; Metabolic syndrome; Psoriasis; Psoriatic
   arthritis comorbidities
ID C-REACTIVE PROTEIN; CARDIOVASCULAR RISK-FACTORS; NECROSIS-FACTOR-ALPHA;
   RHEUMATOID-ARTHRITIS; METABOLIC SYNDROME; MYOCARDIAL-INFARCTION;
   CLINICAL-FEATURES; VASCULAR-DISEASES; MALIGNANT-TUMORS; LIPID PROFILE
AB Psoriasis is a common chronic inflammatory disease that is associated with serious comorbidities, including psoriatic arthritis, reduced quality of life, depression, malignancy, and cardiovascular comorbidities. Patients with psoriasis have been shown to have an increased incidence of metabolic syndrome and cardiovascular disease compared with the general population. The chronic inflammatory nature of psoriasis has been suggested to be a contributing and potentially independent risk factor for the development of cardiovascular comorbidities. Understanding the interrelationship between these conditions is important for the management of psoriasis and the associated comorbidities. This review will focus on the range of comorbidities associated with psoriasis, with emphasis on cardiometabolic conditions and the aim of encouraging primary care physicians to screen psoriatic patients for cardiometabolic disorders and risk factors. (C) 2009 Elsevier Inc. All rights reserved. The American Journal of Medicine (2009) 122, 1150.e1-1150.e9
C1 [Gottlieb, Alice B.] Tufts Med Ctr, Boston, MA 02111 USA.
   [Dann, Frank] VA Med Ctr, Long Beach, CA USA.
C3 Tufts Medical Center
RP Gottlieb, AB (corresponding author), Tufts Med Ctr, 800 Washington St,Box 114, Boston, MA 02111 USA.
EM agottlieb@tuftsmedicalcenter.org
FU Amgen; Centocor, Inc; Wyeth Pharmaceuticals; Immune Control; Celgene
   Corp; Pharmacare; Incyte; Novo Nordisk; Pfizer; Abbott
FX Funding for writing assistance was provided by Amgen.Almost all of Dr
   Gottlieb's consulting and speaking fees are paid to Tufts Medical
   Center. Dr Gottlieb is a member of the speakers bureau of Amgen Inc, and
   Wyeth Pharmaceuticals; has current consulting/advisory board agreements
   with Amgen Inc, Centocor, Inc, Wyeth Pharmaceuticals, Celgene Corp,
   Bristol-Myers Squibb Co, Beiersdorf, Inc, Abbott, Roche, TEVA, Actelion,
   UCB, Novo Nordisk, Almirall, Immune Control, Dermipsor Ltd., Incyte,
   Magen Biosciences, Stieffel, and Puretech; Tufts Medical Center has
   received research/educational grants from Centocor, Inc, Amgen Inc,
   Wyeth Pharmaceuticals, Immune Control, Celgene Corp, Pharmacare, Incyte,
   Novo Nordisk, Pfizer, and Abbott. Dr Dann is a former Amgen employee. He
   has participated on speakers bureaus for Amgen Inc and Wyeth
   Pharmaceuticals and has a consulting agreement with Amgen.
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NR 101
TC 155
Z9 165
U1 0
U2 10
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0002-9343
EI 1555-7162
J9 AM J MED
JI Am. J. Med.
PD DEC
PY 2009
VL 122
IS 12
AR 1150.e1
DI 10.1016/j.amjmed.2009.06.021
PG 9
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 526YW
UT WOS:000272333700023
PM 19958894
DA 2025-06-11
ER

PT J
AU Gozdzik, A
   Salehi, R
   O'Campo, P
   Stergiopoulos, V
   Hwang, SW
AF Gozdzik, Agnes
   Salehi, Roxana
   O'Campo, Patricia
   Stergiopoulos, Vicky
   Hwang, Stephen W.
TI Cardiovascular risk factors and 30-year cardiovascular risk in homeless
   adults with mental illness
SO BMC PUBLIC HEALTH
LA English
DT Article
DE Cardiovascular diseases; Cardiovascular risk factors; Homeless persons;
   Mental illness
ID NEUROPSYCHIATRIC INTERVIEW MINI; CORONARY-HEART-DISEASE; METABOLIC
   SYNDROME; SMOKING-CESSATION; HEALTH-CARE; PSYCHOLOGICAL STRESS;
   PREVALENCE; POPULATION; MORTALITY; SCHIZOPHRENIA
AB Background: Cardiovascular disease (CVD) is a leading cause of death among homeless people. This study examines CVD risk factors and 30-year CVD risk in a population of homeless individuals with mental illness.
   Methods: CVD risks factors were assessed in 352 homeless individuals with mental illness in Toronto, Canada, at the time of their enrollment in the At Home/Chez Soi Project, a randomized trial of a Housing First intervention. The 30-year risk for CVD (coronary death, myocardial infarction, and fatal or nonfatal stroke) was calculated using published formulas and examined for association with need for mental health services, diagnosis of psychotic disorder, sex, ethnicity, access to a family physician and diagnosis of substance dependence.
   Results: The 30-year CVD risk for study participants was 24.5 +/- 18.4%, more than double the reference normal of 10.1 +/- 7.21% (difference = -13.0% 95% CI -16.5% to -9.48%). Univariate analyses revealed 30-year CVD risk was greater among males (OR 3.99, 95% CI 2.47 to 6.56) and those who were diagnosed with substance dependence at baseline (OR 1.94 95% CI 1.23 to 3.06) and reduced among those who were non-white (OR 0.62 95% CI 0.39 to 0.97). In adjusted analyses, only male sex (OR 4.71 95% CI 2.76 to 8.05) and diagnosis of substance dependence (OR 1.78 95% CI 1.05 to 3.00) remained associated with increased CVD risk.
   Conclusions: Homeless people with mental illness have highly elevated 30-year CVD risk, particularly among males and those diagnosed with substance dependence. This study adds to the literature by reporting on CVD risk in a particularly vulnerable population of homeless individuals experiencing mental illness, and by using a 30-year CVD risk calculator which provides a longer time-frame during which the effect of modifiable CVD risk factors could be mitigated.
C1 [Gozdzik, Agnes; Salehi, Roxana; O'Campo, Patricia; Stergiopoulos, Vicky; Hwang, Stephen W.] St Michaels Hosp, Li Ka Shing Knowledge Inst, Ctr Res Inner City Hlth, Toronto, ON M5B 1W8, Canada.
   [O'Campo, Patricia] Univ Toronto, Dalla Lana Sch Publ Hlth, Toronto, ON M5T 3M7, Canada.
   [Stergiopoulos, Vicky] Univ Toronto, Dept Psychiat, Toronto, ON M5T 1R8, Canada.
   [Hwang, Stephen W.] Univ Toronto, Div Gen Internal Med, Dept Med, Toronto, ON, Canada.
C3 University of Toronto; Saint Michaels Hospital Toronto; Li Ka Shing
   Knowledge Institute; University of Toronto; University of Toronto;
   University of Toronto
RP Hwang, SW (corresponding author), St Michaels Hosp, Li Ka Shing Knowledge Inst, Ctr Res Inner City Hlth, 30 Bond St, Toronto, ON M5B 1W8, Canada.
EM hwangs@smh.ca
RI Hwang, Stephen/GVR-7773-2022; Hwang, Stephen/D-2297-2011
OI Hwang, Stephen/0000-0002-1276-1101
FU Health Canada; BMO Financial Group
FX The authors would like to thank the Toronto site research team,
   including research coordinators, research assistants, PWLE group
   members, service support providers and participants for their
   contributions to success of this study. We also thank Jayne Barker
   (2008-11), Ph. D., Cameron Keller (2011-12), and Catharine Hume
   (2012-present) Mental Health Commission of Canada At Home/Chez Soi
   National Project Leads, Paula Goering, Ph. D. The National Research
   Lead, the National Research Team, the five site research teams, the Site
   Co-ordinators, and the numerous service and housing providers, as well
   as persons with lived experience, who have contributed to this project
   and the research. This research has been made possible through a
   financial contribution from Health Canada. The views expressed herein
   solely represent the authors.The authors gratefully acknowledge the
   support of BMO Financial Group, funders of the Vulnerable Populations
   Unit at St. Michael's Hospital. The views expressed in this publication
   are the views of the authors and do not necessarily reflect the views of
   BMO Financial Group. The views expressed herein solely represent the
   authors.
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NR 72
TC 26
Z9 40
U1 0
U2 10
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2458
J9 BMC PUBLIC HEALTH
JI BMC Public Health
PD FEB 23
PY 2015
VL 15
AR 165
DI 10.1186/s12889-015-1472-4
PG 13
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA CB6RA
UT WOS:000349753100001
PM 25886157
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Nover, CH
AF Nover, Cynthia Helen
TI Mental Health in Primary Care: Perceptions of Augmented Care for
   Individuals With Serious Mental Illness
SO SOCIAL WORK IN HEALTH CARE
LA English
DT Article
DE mental health; primary care; care coordination; integrated care;
   qualitative; serious mental health
ID METABOLIC SYNDROME; LIFE-STYLE; CARDIOVASCULAR RISK; SCHIZOPHRENIA;
   INTERVENTION; PEOPLE; IMPACT
AB Individuals with serious mental illness are at increased risk of developing secondary physical illnesses because of lifestyle and psychiatric treatment-related factors. Many individuals with mental illness participate in primary care clinics, such as Placer County Community Clinic (PCCC), which provides primary care and medication-only psychiatric services to low-income county residents. This qualitative study describes an augmented care program provided to this population at PCCC and explores participant experiences with that program. The augmented program consisted of a full-time social worker and part-time registered nurse working as a team to coordinate care between providers, and provide psychosocial education and illness management support. Previous studies have demonstrated that similar programs result in improved clinical outcomes for people with mental illness but have largely not included perspectives of participants in these pilot programs. This article includes participant reports about medical service needs, barriers, and beneficial elements of the augmented program. Medical service needs included the need to provide input in treatment and to be personally valued. Barriers ranged from doubts about provider qualifications to concerns about medication. Elements of the augmented care program that participants found beneficial were those involving care coordination, social support, and weight management support.
C1 [Nover, Cynthia Helen] Eastern Washington Univ, Sch Social Work, Cheney, WA 99004 USA.
C3 Eastern Washington University
RP Nover, CH (corresponding author), Eastern Washington Univ, 208 Senior Hall, Cheney, WA 99004 USA.
EM cnover@ewu.edu
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   Rubio Ruby Navarro, 2007, Psychol Health Med, V12, P334, DOI 10.1080/13548500600864053
NR 13
TC 13
Z9 16
U1 0
U2 17
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 0098-1389
EI 1541-034X
J9 SOC WORK HEALTH CARE
JI Soc. Work Health Care
PD AUG 1
PY 2013
VL 52
IS 7
BP 656
EP 668
DI 10.1080/00981389.2013.797537
PG 13
WC Social Work
WE Social Science Citation Index (SSCI)
SC Social Work
GA 201LV
UT WOS:000323144000003
PM 23947541
DA 2025-06-11
ER

PT J
AU Gyawali, P
   Richards, RS
AF Gyawali, Prajwal
   Richards, Ross S.
TI Association of altered hemorheology with oxidative stress and
   inflammation in metabolic syndrome
SO REDOX REPORT
LA English
DT Article
DE Erythrocyte aggregation; Erythrocyte deformability; Glutathione;
   Metabolic syndrome; Whole blood viscosity
ID RED-BLOOD-CELL; AMERICAN-HEART-ASSOCIATION; C-REACTIVE PROTEIN;
   RISK-FACTORS; ERYTHROCYTE AGGREGATION; FIBRINOGEN; DISEASE; OBESITY;
   DYSFUNCTION; MECHANISMS
AB Objective: We have shown increased whole blood viscosity (WBV), decreased erythrocyte deformability, and increased erythrocyte aggregation in metabolic syndrome (MetS) in our previous study. The objective of the study was to find out if the altered hemorheology shown in MetS in our previous study is associated with chronic inflammation and oxidative stress in the same subjects.
   Methods: One hundred recruited participants were classified into three groups based on the number of the MetS components present following National Cholesterol Education Program, Adult Treatment Panel III definitions. WBV, erythrocyte aggregation, erythrocyte deformability, oxidative stress markers (erythrocyte reduced glutathione (GSH), superoxide dismutase (SOD), and urinary isoprostanes), inflammatory markers high-sensitivity C-reactive protein (hsCRP), and thrombotic marker D-dimer were measured. Data were analyzed by IBM SPSS 20 software.
   Results: We found a significant association of altered hemorheology with chronic inflammation and oxidative stress in MetS. There was a linear increase in the level of hsCRP and a linear decrease in the level of SOD and GSH across the quartiles of erythrocyte aggregation. Similarly, the thrombotic marker D-dimer showed a linear increase and oxidative stress marker GSH showed a linear decrease trend across the quartiles of WBV.
   Discussion: Alterations of hemorheology in MetS are probably due to the effect of chronic inflammation and oxidative stress. The negative effects of chronic inflammation and oxidative stress on the cardiovascular system could be due to the resulting altered hemorheology.
C1 [Gyawali, Prajwal; Richards, Ross S.] Charles Sturt Univ, Sch Community Hlth, Albury, NSW 2640, Australia.
C3 Charles Sturt University
RP Gyawali, P (corresponding author), Charles Sturt Univ, Sch Community Hlth, Thurgoona Campus, Albury, NSW 2640, Australia.
EM clbioprajwal@gmail.com
OI Gyawali, Prajwal/0000-0003-0975-5576
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NR 40
TC 28
Z9 31
U1 0
U2 8
PU MANEY PUBLISHING
PI LEEDS
PA STE 1C, JOSEPHS WELL, HANOVER WALK, LEEDS LS3 1AB, W YORKS, ENGLAND
SN 1351-0002
J9 REDOX REP
JI Redox Rep.
PD MAY
PY 2015
VL 20
IS 3
BP 139
EP 144
DI 10.1179/1351000214Y.0000000120
PG 6
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA CF1JC
UT WOS:000352300000007
PM 25494675
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Bigal, ME
   Lipton, RB
AF Bigal, Marcelo E.
   Lipton, Richard B.
TI Putative mechanisms of the relationship between obesity and migraine
   progression
SO CURRENT PAIN AND HEADACHE REPORTS
LA English
DT Review
ID BODY-MASS INDEX; METABOLIC SYNDROME; ADIPOSE-TISSUE; RISK-FACTORS;
   CARDIOVASCULAR-DISEASE; RECEPTOR ACTIVATION; POPULATION; HEADACHE;
   SYSTEM; DEPRESSION
AB Studies suggest that obesity is associated with migraine progression from an episodic into a chronic form. We discuss putative mechanisms to justify this relationship. Several of the inflammatory mediators that are increased in obese individuals are important in migraine pathophysiology, including interleukins and calcitonin gene-related peptide. Both migraine and obesity are prothrombotic states. Substances that are important in metabolic control are nociceptive at certain levels. Hypothalamic dysfunction in the orexin pathways seems to be a risk factor for both conditions. In addition, we discuss the importance of metabolic syndrome and autonomic dysfunction in modulating the obesity/migraine progression relationship.
C1 [Bigal, Marcelo E.] Merck Res Labs, White House Stn, NJ 08889 USA.
C3 Merck & Company
RP Bigal, ME (corresponding author), Merck Res Labs, 1 Merck Dr,POB 100, White House Stn, NJ 08889 USA.
EM marcelo_bigal@merck.com
RI Lipton, Richard/AAY-2818-2021
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NR 48
TC 28
Z9 30
U1 0
U2 1
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1531-3433
EI 1534-3081
J9 CURR PAIN HEADACHE R
JI Curr. Pain Headache Rep.
PD JUN
PY 2008
VL 12
IS 3
BP 207
EP 212
DI 10.1007/s11916-008-0036-z
PG 6
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 333BY
UT WOS:000258128200008
PM 18796271
DA 2025-06-11
ER

PT J
AU Gonzalez-Rodríguez, A
   Seeman, MV
   Natividad, M
   Barrio, P
   Román, E
   Balagué, A
   Paolini, JP
   Monreal, JA
AF Gonzalez-Rodriguez, Alexandre
   Seeman, Mary V.
   Natividad, Mentxu
   Barrio, Pablo
   Roman, Eloisa
   Balague, Ariadna
   Paolini, Jennipher Paola
   Monreal, Jose Antonio
TI Review of Male and Female Care Needs in Schizophrenia: A New Specialized
   Clinical Unit for Women
SO WOMEN
LA English
DT Review
DE schizophrenia; women; community mental health; psychosis
ID OBSTRUCTIVE SLEEP-APNEA; MENTAL-HEALTH-SERVICES; BONE-MINERAL DENSITY;
   SYNDROME SCALE PANSS; GENDER-DIFFERENCES; SEX-DIFFERENCES; ANTIPSYCHOTIC
   TREATMENT; PHYSICAL-ACTIVITY; BROKEN MARRIAGES; RISK-FACTORS
AB Women with schizophrenia require health interventions that differ, in many ways, from those of men. The aim of this paper is to review male and female care needs and describe a newly established care unit for the treatment of women with schizophrenia. After reviewing the literature on the differentiated needs of men and women with schizophrenia, we describe the new unit's assessment, intervention, and evaluation measures. The program consists of (1) individual/group patient/family therapy, (2) therapeutic drug monitoring and adherence checks, (3) perinatal mental health, (4) medical liaison, (5) suicide prevention/intervention, (6) social services with special focus on parenting, domestic abuse, and sexual exploitation, (7) home-based services, (8) peer support, (9) occupational therapies (physical activity and leisure programs), and (10) psychoeducation for both patients and families. Still in the planning stage are quality evaluation of diagnostic assessment, personalized care, drug optimization, health screening (reproductive health, metabolic syndrome, cardiovascular health, cancer, menopausal status), and patient and family satisfaction with services provided. Woman-specific care represents an important resource that promises to deliver state-of-the-art treatment to women and, ideally, prevent mental illness in their offspring.
C1 [Gonzalez-Rodriguez, Alexandre; Natividad, Mentxu; Roman, Eloisa; Balague, Ariadna; Paolini, Jennipher Paola; Monreal, Jose Antonio] Univ Barcelona UB, Mutua Terrassa Univ Hosp, Dept Mental Hlth, CIBERSAM, Terrassa 08221, Spain.
   [Seeman, Mary V.] Univ Toronto, Dept Psychiat, Toronto, ON M5P 3L6, Canada.
   [Barrio, Pablo] Univ Barcelona UB, Hosp Clin Barcelona, Dept Psychiat & Psychol, IDIBAPS, Barcelona 08036, Spain.
   [Monreal, Jose Antonio] UAB, Inst Neurociencies, Terrassa 08221, Spain.
C3 Hospital Universitario Mutua Terrassa; CIBER - Centro de Investigacion
   Biomedica en Red; CIBERSAM; University of Toronto; University of
   Barcelona; Hospital Clinic de Barcelona; IDIBAPS; Autonomous University
   of Barcelona
RP Gonzalez-Rodríguez, A (corresponding author), Univ Barcelona UB, Mutua Terrassa Univ Hosp, Dept Mental Hlth, CIBERSAM, Terrassa 08221, Spain.
EM alexandregonzalez@mutuaterrassa.cat
RI Barrio, Pablo/AFD-8541-2022
OI Gonzalez-Rodriguez, Alexandre/0000-0003-1855-8566; MONREAL-ORTIZ, JOSE
   ANTONIO/0000-0002-0906-927X
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NR 124
TC 6
Z9 6
U1 2
U2 5
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2673-4184
J9 WOMEN-BASEL
JI Women
PD MAR
PY 2023
VL 3
IS 1
BP 107
EP 120
DI 10.3390/women3010009
PG 14
WC Public, Environmental & Occupational Health; Women's Studies
WE Emerging Sources Citation Index (ESCI)
SC Public, Environmental & Occupational Health; Women's Studies
GA QF9N9
UT WOS:001219583100001
OA gold
DA 2025-06-11
ER

PT J
AU Claesson, M
   Birgander, LS
   Jansson, JH
   Lindahl, B
   Burell, G
   Asplund, K
   Mattsson, C
AF Claesson, M.
   Birgander, L. S.
   Jansson, J. -H.
   Lindahl, B.
   Burell, G.
   Asplund, K.
   Mattsson, C.
TI Cognitive-behavioural stress management does not improve biological
   cardiovascular risk indicators in women with ischaemic heart disease: a
   randomized-controlled trial
SO JOURNAL OF INTERNAL MEDICINE
LA English
DT Article
DE C-reactive protein; fibrinolysis; insulin resistance; leptin; myocardial
   ischaemia; women
ID ACUTE MYOCARDIAL-INFARCTION; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   VITAL EXHAUSTION; PLASMA LEPTIN; LIFE-STYLE; INFLAMMATION; DEPRESSION;
   INTERVENTION; FIBRINOLYSIS
AB Objectives. Psychosocial factors, such as stress and vital exhaustion, are associated with an increased risk of cardiovascular events, and women report more psychosocial ill-being after an acute myocardial infarction than men. We have earlier shown that a cognitive-behavioural intervention in women with ischaemic heart disease (IHD) improved psychosocial well-being. In the present study, we tested the hypothesis that the improvement in psychosocial well-being is associated with an improvement in biochemical indicators of cardiovascular risk.
   Design. Randomized-controlled trial in northern Sweden.
   Setting. Outpatient care.
   Subjects. Women with IHD were randomized to either a 1-year cognitive-behavioural stress management programme or usual care. Of the 159 women who completed the study, 77 were in the intervention group, and 82 in the control group.
   Interventions. A 1-year cognitive-behavioural stress management programme versus conventional care.
   Results. Group assignment was not found to be a determinant of waist circumference, high sensitive C-reactive protein (hs-CRP), fibrinogen, von Willebrand factor (vWF), plasminogen activator inhibitor type 1 (PAI-1) activity, tissue plasminogen activator (tPA) activity, tPA antigen, tPA-PAI-1 complex, leptin, or HOMA2 insulin resistance index (HOMA2-IR) at follow up. Changes in psychosocial variables were not associated with changes in any of the biological risk indicators.
   Conclusions. Even if our cognitive-behavioural stress management programme had effects on proximal targets, such as stress behaviour and vital exhaustion, we found no improvement in intermediate biochemical targets related to the metabolic syndrome and IHD. Our results challenge the proposition that the relationship between psychological well-being and biological cardiovascular risk indicators is a direct cause-effect phenomenon.
C1 Umea Univ Hosp, Dept Publ Hlth & Clin Med Med, SE-90185 Umea, Sweden.
   Umea Univ Hosp, Dept Publ Hlth & Clin Med Occupat Med, SE-90185 Umea, Sweden.
   Skelleftea Hosp, Dept Publ Hlth & Clin Med Med & Geriatr, Skelleftea, Sweden.
   Umea Univ Hosp, Dept Publ Hlth & Clin Med Behav Med, SE-90185 Umea, Sweden.
   Uppsala Univ, Dept Publ Hlth, Uppsala, Sweden.
C3 Umea University; Umea University Hospital; Umea University; Umea
   University Hospital; Umea University; Umea University Hospital; Uppsala
   University
RP Claesson, M (corresponding author), Umea Univ Hosp, Dept Publ Hlth & Clin Med Med, SE-90185 Umea, Sweden.
EM maria.claesson@medicin.umu.se
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NR 45
TC 22
Z9 24
U1 1
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0954-6820
EI 1365-2796
J9 J INTERN MED
JI J. Intern. Med.
PD OCT
PY 2006
VL 260
IS 4
BP 320
EP 331
DI 10.1111/j.1365-2796.2006.01691.x
PG 12
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 082SG
UT WOS:000240406900003
PM 16961669
OA Bronze
DA 2025-06-11
ER

PT J
AU Parletta, N
   Zarnowiecki, D
   Cho, JH
   Wilson, A
   Procter, N
   Gordon, A
   Bogomolova, S
   O'Dea, K
   Strachan, J
   Ballestrin, M
   Champion, A
   Meyer, BJ
AF Parletta, Natalie
   Zarnowiecki, Dorota
   Cho, Jihyun
   Wilson, Amy
   Procter, Nicholas
   Gordon, Andrea
   Bogomolova, Svetlana
   O'Dea, Kerin
   Strachan, John
   Ballestrin, Matt
   Champion, Andrew
   Meyer, Barbara J.
TI People with schizophrenia and depression have a low omega-3 index
SO PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
LA English
DT Article
DE Polyunsaturated fatty acids; Omega-3; Omega-3 index; Mental illness;
   Depression; Schizophrenia; Cardiovascular disease
ID RANDOMIZED CONTROLLED-TRIALS; C-REACTIVE PROTEIN; RISK-FACTOR;
   CONSTRUCT-VALIDITY; METABOLIC SYNDROME; NORMATIVE DATA; FATTY-ACIDS;
   FISH-OIL; OMEGA-3-FATTY-ACIDS; METAANALYSIS
AB Cardiovascular disease (CVD) is higher in people with mental illness and is associated with a 30 year higher mortality rate in this population. Erythrocyte docosahexaenoic acid (DHA) plus eicosapentaenoic acid (EPA) (omega-3 index) <= 4% is a marker for increased mortality risk from CVD while > 8% is protective. Omega-3 polyunsaturated fatty acids are also important for brain function and may ameliorate symptoms of mental illness. We investigated the erythrocyte omega-3 index in people with mental illness. One hundred and thirty adults aged 18-65 years (32.6% male) with schizophrenia (n=14) and depression (n=116) provided blood samples and completed physiological assessments and questionnaires. Both populations had risk factors for metabolic syndrome and CVD. The average omega-3 index was 3.95% (SD=1.06), compared to an estimated 5% in the Australian population. These data indicate an unfavourable omega-3 profile in people with mental illness that could contribute to higher CVD risk. (C) 2016 Elsevier Ltd. All rights reserved.
C1 [Parletta, Natalie; Zarnowiecki, Dorota; Cho, Jihyun; O'Dea, Kerin] Univ S Australia, Sch Hlth Sci, Sansom Inst Hlth Res, Ctr Populat Hlth Res, Adelaide, SA 5001, Australia.
   [Wilson, Amy; Bogomolova, Svetlana] Univ S Australia, Sch Business & Mkt, Adelaide, SA 5001, Australia.
   [Procter, Nicholas; Gordon, Andrea] Univ S Australia, Sch Nursing & Midwifery, Adelaide, SA 5001, Australia.
   [Strachan, John; Ballestrin, Matt; Champion, Andrew] Local Southern Adelaide Hlth Network, Mental Hlth Directorate, Adelaide, SA, Australia.
   [Meyer, Barbara J.] Univ Wollongong, Sch Med, Wollongong, NSW, Australia.
C3 University of South Australia; University of South Australia; Flinders
   University South Australia; University of South Australia; University of
   Wollongong
RP Parletta, N (corresponding author), Univ S Australia, Sch Hlth Sci, Sansom Inst Hlth Res, Ctr Populat Hlth Res, Adelaide, SA 5001, Australia.
EM natalie.parletta@unisa.edu.au; dorota.zarnowiecki@unisa.edu.au;
   catherine.cho@unisa.edu.au; amy.wilson@unisa.edu.au;
   nicholas.procter@unisa.edu.au; andrea.fielder@unisa.edu.au;
   svetlana.bogomolova@unisa.edu.au; kerin.odea@unisa.edu.au;
   john.strachan2@health.sa.gov.au; matt.ballestrin@health.sa.gov.au;
   andrew.champion@health.sa.gov.au; bmeyer@uow.edu.au
RI Gordon, Andrea/G-4567-2010; Meyer, Barbara/AAC-6078-2019; Strachan,
   John/AAD-1240-2020; Wilson, Amy/AAB-8106-2020; Bogomolova,
   Svetlana/H-1537-2011; Zarnowiecki, Dorota/C-9878-2015; Procter, Nicholas
   Gerard/G-1992-2011; Parletta, Natalie/A-7880-2008
OI Wilson, Amy/0000-0002-3855-0281; Bogomolova,
   Svetlana/0000-0003-4449-6514; Zarnowiecki, Dorota/0000-0003-0874-7830;
   Procter, Nicholas Gerard/0000-0002-7289-3165; Parletta,
   Natalie/0000-0003-2322-5555; Meyer, Barbara J/0000-0001-7962-7890
FU NHMRC (National Health and Medical Research Council) [320860, 631947]
FX We acknowledge and thank the team at the TPC for their support of study
   1 and assistance in obtaining blood samples from their consumers. We
   gratefully thank Louise Massie and the Sansom Health Clinic for support
   with clinic visits and administration associated with study 2, Lauren
   Roach for assistance with fatty analysis and all participants for taking
   part. NP (formerly Sinn), DZ and AW are supported by NHMRC (National
   Health and Medical Research Council) Program Grant funding (# 320860 and
   631947). Epax, Pathway International, Edgell, John West and Cobram
   Estate provided fish oil supplements, food and extra virgin olive oil
   for Study 2 from which these baseline data are derived.
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   Zarnowiecki D., 6 MONTH RANDOM UNPUB
NR 49
TC 33
Z9 36
U1 0
U2 20
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0952-3278
EI 1532-2823
J9 PROSTAG LEUKOTR ESS
JI Prostaglandins Leukot. Essent. Fatty Acids
PD JUL
PY 2016
VL 110
BP 42
EP 47
DI 10.1016/j.plefa.2016.05.007
PG 6
WC Biochemistry & Molecular Biology; Cell Biology; Endocrinology &
   Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology; Endocrinology &
   Metabolism
GA DP0MW
UT WOS:000378184900006
PM 27255642
DA 2025-06-11
ER

PT J
AU Cheema, BS
   Houridis, A
   Busch, L
   Raschke-Cheema, V
   Melville, GW
   Marshall, PW
   Chang, D
   Machliss, B
   Lonsdale, C
   Bowman, J
   Colagiuri, B
AF Cheema, Birinder S.
   Houridis, Angelique
   Busch, Lisa
   Raschke-Cheema, Verena
   Melville, Geoff W.
   Marshall, Paul W.
   Chang, Dennis
   Machliss, Bianca
   Lonsdale, Chris
   Bowman, Julia
   Colagiuri, Ben
TI Effect of an office worksite-based yoga program on heart rate
   variability: outcomes of a randomized controlled trial
SO BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Article
DE Stress; Quality of life; Anxiety; Physical fitness; Mood
ID METABOLIC SYNDROME; STRESS; EXERCISE; DISEASE; HEALTH; ANXIETY; RISK;
   METAANALYSIS; MORTALITY; QUALITY
AB Background: Chronic work-related stress is an independent risk factor for cardiometabolic diseases and associated mortality, particularly when compounded by a sedentary work environment. The purpose of this study was to determine if an office worksite-based hatha yoga program could improve physiological stress, evaluated via heart rate variability (HRV), and associated health-related outcomes in a cohort of office workers.
   Methods: Thirty-seven adults employed in university-based office positions were randomized upon the completion of baseline testing to an experimental or control group. The experimental group completed a 10-week yoga program prescribed three sessions per week during lunch hour (50 min per session). An experienced instructor led the sessions, which emphasized asanas (postures) and vinyasa (exercises). The primary outcome was the high frequency (HF) power component of HRV. Secondary outcomes included additional HRV parameters, musculoskeletal fitness (i.e. push-up, side-bridge, and sit & reach tests) and psychological indices (i.e. state and trait anxiety, quality of life and job satisfaction).
   Results: All measures of HRV failed to change in the experimental group versus the control group, except that the experimental group significantly increased LF: HF (p = 0.04) and reduced pNN50 (p = 0.04) versus control, contrary to our hypotheses. Flexibility, evaluated via sit & reach test increased in the experimental group versus the control group (p < 0.001). No other adaptations were noted. Post hoc analysis comparing participants who completed >= 70% of yoga sessions (n = 11) to control (n = 19) yielded the same findings, except that the high adherers also reduced state anxiety (p = 0.02) and RMSSD (p = 0.05), and tended to improve the push-up test (p = 0.07) versus control.
   Conclusions: A 10-week hatha yoga intervention delivered at the office worksite during lunch hour did not improve HF power or other HRV parameters. However, improvements in flexibility, state anxiety and musculoskeletal fitness were noted with high adherence. Future investigations should incorporate strategies to promote adherence, involve more frequent and longer durations of yoga training, and enrol cohorts who suffer from higher levels of work-related stress.
C1 [Cheema, Birinder S.; Houridis, Angelique; Busch, Lisa; Raschke-Cheema, Verena; Melville, Geoff W.; Marshall, Paul W.; Chang, Dennis; Lonsdale, Chris; Bowman, Julia] Univ Western Sydney, Sch Sci & Hlth, Penrith, NSW 2751, Australia.
   [Chang, Dennis] Univ Western Sydney, Ctr Complementary Med Res, Campbelltown, NSW 2751, Australia.
   [Machliss, Bianca] Yoga Synergy Pty Ltd, Bondi Jct, NSW 2022, Australia.
   [Colagiuri, Ben] Univ Sydney, Sch Psychol, Sydney, NSW 2006, Australia.
C3 Western Sydney University; Western Sydney University; University of
   Sydney
RP Cheema, BS (corresponding author), Univ Western Sydney, Sch Sci & Hlth, Penrith, NSW 2751, Australia.
EM B.Cheema@uws.edu.au
RI Marshall, Paul/C-8996-2009; Lonsdale, Chris/T-8710-2017
OI Colagiuri, Ben/0000-0003-2157-2641; Melville,
   Geoffrey/0000-0003-2819-6853; Marshall, Paul/0000-0002-1631-1925;
   Cheema, Birinder/0000-0003-1979-590X; Lonsdale,
   Chris/0000-0002-2523-5565
FU University of Western Sydney
FX This trial was funded by the University of Western Sydney. We thank Paul
   Fahey for providing consultation regarding statistical analyses.
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NR 45
TC 55
Z9 67
U1 1
U2 16
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1472-6882
J9 BMC COMPLEM ALTERN M
JI BMC Complement. Altern. Med.
PD APR 10
PY 2013
VL 13
AR 82
DI 10.1186/1472-6882-13-82
PG 10
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Integrative & Complementary Medicine
GA 138HD
UT WOS:000318498700001
PM 23574691
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Matsuda, M
   Shimomura, I
AF Matsuda, Morihiro
   Shimomura, Iichiro
TI Increased oxidative stress in obesity: Implications for metabolic
   syndrome, diabetes, hypertension, dyslipidemia, atherosclerosis, and
   cancer
SO OBESITY RESEARCH & CLINICAL PRACTICE
LA English
DT Review
DE Oxidative stress; Obesity; Metabolic syndrome
ID HIGH-DENSITY-LIPOPROTEIN; VISCERAL FAT ACCUMULATION; ADIPOSE-TISSUE
   INFLAMMATION; INDUCED INSULIN-RESISTANCE; NAD(P)H OXIDASE ACTIVITY;
   ENDOTHELIAL DYSFUNCTION; SUPEROXIDE-PRODUCTION; HEPATIC STEATOSIS;
   ALDOSE REDUCTASE; TUMOR-FORMATION
AB Obesity, especially of the abdominal type, is a health problem that constitutes metabolic syndrome and increases the incidence of various diseases, including diabetes, hypertension, dyslipidemia, atherosclerosis, and cancer. Various mechanisms linking obesity to these associated diseases have been postulated. One candidate is oxidative stress, which has been implicated in vascular complications of diabetes and in pancreatic beta-cell failure in diabetes. Notably, obese people without diabetes also display elevated levels of systemic oxidative stress. In addition, levels of oxidative stress are increased in the adipose tissue in obese mice. Treating obese mice with antioxidant agents attenuates the development of diabetes. In 3T3-L1 adipocytes, increases in reactive oxygen species (ROS) occur with lipid accumulation; the addition of free fatty acids elevates ROS generation further. Thus, adipose tissue represents an important source of ROS; ROS may contribute to the development of obesity-associated insulin resistance and type 2 diabetes. Moreover, the levels of oxidative stress present in several other types of cells or tissues, including those in the brain, arterial walls, and tumors, have been implicated in the pathogenesis associated with hypertension, atherosclerosis, and cancer. The increased levels of systemic oxidative stress that occur in obesity may contribute to the obesity-associated development of these diseases. (C) 2013 Asian Oceanian Association for the Study of Obesity. Published by Elsevier Ltd. All rights reserved.
C1 [Matsuda, Morihiro] Kure Med Ctr, Natl Hosp Org, Inst Clin Res, Hiroshima, Japan.
   [Matsuda, Morihiro] Chugoku Canc Ctr, Hiroshima, Japan.
   [Shimomura, Iichiro] Osaka Univ, Grad Sch Med, Dept Metab Med, Osaka, Japan.
C3 The University of Osaka
RP Matsuda, M (corresponding author), Kure Med Ctr, Natl Hosp Org, Inst Clin Res, 3-1 Aoyama Cho, Kure, Hiroshima 7370023, Japan.
EM morihiro-m@kure-nh.go.jp
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NR 117
TC 479
Z9 522
U1 3
U2 161
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1871-403X
EI 1878-0318
J9 OBES RES CLIN PRACT
JI Obes. Res. Clin. Pract.
PD SEP-OCT
PY 2013
VL 7
IS 5
BP E330
EP E341
DI 10.1016/j.orcp.2013.05.004
PG 12
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 232EU
UT WOS:000325475100002
PM 24455761
DA 2025-06-11
ER

PT J
AU Stoohs, RA
   Gold, MS
AF Stoohs, Riccardo A.
   Gold, Morris S.
TI Symptoms of sleep disordered breathing: Association with the
   apnea-hypopnea index and somatic arousal
SO SLEEP MEDICINE
LA English
DT Article
DE Sleep apnea; Autonomic nervous system; Symptoms of sleep apnea; Sleep
   apnea severity; Excessive daytime sleepiness; Sleep apnea diagnosis
ID AIRWAY-RESISTANCE SYNDROME; DAYTIME SLEEPINESS; SYMPATHETIC ACTIVITY;
   METABOLIC SYNDROME; CHRONIC STRESS; FATIGUE; DEPRESSION; ANXIETY; MODEL
AB We investigated the association of typical symptoms of obstructive sleep apnea with a measure of daytime somatic arousal and with the apnea-hypopnea index. We extended the finding of an association between sleepiness, fatigue and somatic arousal previously reported in a US sleep apnea population to a German sleep apnea population (n 1/4 374) and to other typical sleep apnea symptoms, insomnia, anxiety, daytime alertness and non-restorative sleep.Somatic arousal was measured using the body sensation questionnaire (BSQ). Correlations of apnea-hypopnea index and BSQ were computed with values of polysomnographic variables derived from overnight sleep studies and with severity of OSA symptoms. Apnea-hypopnea index and BSQ scores showed only a small negative correlation with each other; each correlated independently with the Epworth Sleepiness Scale score. Controlling for BSQ score, the apnea-hypopnea index was found to affect sleepiness only when it exceeded 50/h. Severity of all other sleep apnea symptoms did not increase with increasing apnea-hypopnea index. In contrast, severity of all symptoms of sleep apnea increased consistently with increasing BSQ scores. Thus, autonomic stress associated with obstructive sleep apnea may be the driving force behind sleep apnea symptoms rather than the sleep fragmentation associated with obstructive sleep apnea severity (apnea-hypopnea index).These findings support previously reported correlations by Gold and associates between the levels of somatic arousal, sleepiness and fatigue. Using the apnea-hypopnea index and BSQ together renders a more comprehensive assessment of sleep apnea than apnea-hypopnea index alone, which appears to impact only on sleepiness and only when it exceeds 50/h. More work is needed to elucidate the source of the chronic stress, which appears to arise endogenously in affected individuals, likely as a function of sleep disordered breathing, such as snoring/inspiratory flow limitation.(c) 2022 Elsevier B.V. All rights reserved.
C1 [Stoohs, Riccardo A.] Somnolab Sleep Disorders Ctr, Kai 10, D-44263 Dortmund, Germany.
   [Gold, Morris S.] IQVIA Biotech, 1700 Perimeter Pk Dr, Morrisville, NC USA.
   [Stoohs, Riccardo A.] Somnolab, Kai 10, D-44263 Dortmund, Germany.
RP Stoohs, RA (corresponding author), Somnolab, Kai 10, D-44263 Dortmund, Germany.
EM r.stoohs@gmail.com; 72456mg@gmail.com
OI Stoohs, Riccardo/0000-0002-0642-933X
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NR 31
TC 2
Z9 2
U1 1
U2 12
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1389-9457
EI 1878-5506
J9 SLEEP MED
JI Sleep Med.
PD JAN
PY 2023
VL 101
BP 350
EP 356
DI 10.1016/j.sleep.2022.11.003
EA DEC 2022
PG 7
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA E5QB5
UT WOS:000976074800001
PM 36473324
DA 2025-06-11
ER

PT J
AU Gideon, A
   Sauter, C
   Deuber, J
   Grünewald, J
   Wirtz, PH
AF Gideon, Angelina
   Sauter, Christine
   Deuber, Jennifer
   Grunewald, Julia
   Wirtz, Petra H.
TI Aldosterone secretion during the day: Salivary aldosterone awakening
   response and daytime levels
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE Aldosterone awakening response; Aldosterone daytime levels; Salivary
   aldosterone; Sleep duration; Awakening time; Chronic stress
ID PLASMA-RENIN ACTIVITY; MINERALOCORTICOID RECEPTOR; PSYCHOSOCIAL STRESS;
   METABOLIC SYNDROME; CORTISOL; SYSTEM; ANXIETY; HYPERTENSION; DEPRESSION;
   BEHAVIORS
AB Background: The mineralocorticoid hormone aldosterone is a key regulator of the sodium-potassium balance and blood pressure. In excess, aldosterone relates to hypertension and cardiovascular disease (CVD). Here, we systematically investigated aldosterone secretion during the day in terms of salivary aldosterone awakening response (AldAR) and salivary aldosterone daytime levels (AldDay) under controlled conditions in participants' natural environment including assessment of potential confounding variables.
   Methods: In 40 healthy young men, saliva samples for AldAR were collected immediately after awakening and 15, 30, 45, and 60 min thereafter. AldDay levels were measured in 1 h intervals from 9:00-22:00 h. Analyses were complemented by salivary cortisol assessment. Fluid and food intake was standardized and as potential confounders, we assessed awakening time and sleep duration, age, BMI and MAP, as well as chronic stress.
   Results: Awakening was followed by significant increases in salivary aldosterone (p =.004, f= 0.31), returning to baseline levels > 60 min later. Longer sleep duration was associated with lower AldAR (p <.001, f= 0.36). Over the course of the day we observed a continuous decrease of AldDay (p <.001, f= 0.45). Longer sleep duration (p =.097, f=.21), later time of awakening (p <.001, f=.29), and higher chronic stress (p =.041, f=.23) were associated with AldDay characteristics. Circadian aldosterone secretion was positively associated with most cortisol measures.
   Conclusions: We observed an awakening response in salivary aldosterone and could confirm a decrease in aldosterone levels during the day, comparable to cortisol. Significant confounders were sleep-related variables and chronic stress. Clinical implications of circadian aldosterone secretion with respect to CVD risk remain to be elucidated.
C1 [Gideon, Angelina; Sauter, Christine; Deuber, Jennifer; Grunewald, Julia; Wirtz, Petra H.] Univ Konstanz, Biol Work & Hlth Psychol, Univ Str 10, D-78457 Constance, Germany.
   [Wirtz, Petra H.] Univ Konstanz, Ctr Adv Study Collect Behav, Constance, Germany.
C3 University of Konstanz; University of Konstanz
RP Wirtz, PH (corresponding author), Univ Konstanz, Biol Work & Hlth Psychol, Univ Str 10, D-78457 Constance, Germany.
EM petra.wirtz@uni-konstanz.de
RI Wirtz, Petra/G-6317-2011
OI Gideon, Angelina/0000-0002-0774-5684
FU Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) [EXC
   2117 - 422037984]; Swiss National Science Foundation [PP00P1_128565/1];
   Stoll VITA foundation; German Scholars Organization (GSO/CZS 2)
FX This work was funded by the Deutsche Forschungsgemeinschaft (DFG, German
   Research Foundation) under Germany's Excellence Strategy - EXC 2117 -
   422037984, the Swiss National Science Foundation (PP00P1_128565/1), the
   German Scholars Organization (GSO/CZS 2), and the Stoll VITA foundation
   (all to PHW). The funding sources had no impact on the writing of the
   manuscript, or the decision to submit the manuscript for publication.
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NR 69
TC 6
Z9 6
U1 2
U2 8
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
EI 1873-3360
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD MAY
PY 2022
VL 139
AR 105685
DI 10.1016/j.psyneuen.2022.105685
EA FEB 2022
PG 10
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA 2Q0MG
UT WOS:000820122900001
PM 35202970
DA 2025-06-11
ER

PT J
AU Gomez-Pinilla, F
   Tyagi, E
AF Gomez-Pinilla, Fernando
   Tyagi, Ethika
TI Diet and cognition: interplay between cell metabolism and neuronal
   plasticity
SO CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE
LA English
DT Review
DE epigenetics; exercise; membrane fluidity; metabolic syndrome; omega-3
   fatty acids; polyphenols
ID TRAUMATIC BRAIN-INJURY; HIGH-FAT DIET; NEUROTROPHIC FACTOR; OXIDATIVE
   STRESS; SYNAPTIC PLASTICITY; LIPID-PEROXIDATION; HEPATIC STEATOSIS;
   ENERGY-METABOLISM; EXERCISE; CURCUMIN
AB Purpose of studyTo discuss studies in humans and animals revealing the ability of foods to benefit the brain: new information with regards to mechanisms of action and the treatment of neurological and psychiatric disorders.Recent findingsDietary factors exert their effects on the brain by affecting molecular events related to the management of energy metabolism and synaptic plasticity. Energy metabolism influences neuronal function, neuronal signaling, and synaptic plasticity, ultimately affecting mental health. Epigenetic regulation of neuronal plasticity appears as an important mechanism by which foods can prolong their effects on long-term neuronal plasticity.SummaryThe prime focus of the discussion is to emphasize the role of cell metabolism as a mediator for the action of foods on the brain. Oxidative stress promotes damage to phospholipids present in the plasma membrane such as the omega-3 fatty acid docosahexenoic acid, disrupting neuronal signaling. Thus, dietary docosahexenoic acid seems crucial for supporting plasma membrane function, interneuronal signaling, and cognition. The dual action of brain-derived neurotrophic factor in neuronal metabolism and synaptic plasticity is crucial for activating signaling cascades under the action of diet and other environmental factors, using mechanisms of epigenetic regulation.
C1 [Gomez-Pinilla, Fernando] Univ Calif Los Angeles, Dept Integrat Biol & Physiol, Los Angeles, CA 90095 USA.
   Univ Calif Los Angeles, Dept Neurosurg, Los Angeles, CA 90095 USA.
C3 University of California System; University of California Los Angeles;
   University of California System; University of California Los Angeles
RP Gomez-Pinilla, F (corresponding author), Univ Calif Los Angeles, Dept Integrat Biol & Physiol, 621 Charles E Young Dr, Los Angeles, CA 90095 USA.
EM Fgomezpi@ucla.edu
FU National Institutes of Health [NS50465, NS56413]
FX This work was supported by National Institutes of Health Grants NS50465
   and NS56413 (to F.G.-P.).
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NR 73
TC 72
Z9 83
U1 0
U2 35
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1363-1950
EI 1473-6519
J9 CURR OPIN CLIN NUTR
JI Curr. Opin. Clin. Nutr. Metab. Care
PD NOV
PY 2013
VL 16
IS 6
BP 726
EP 733
DI 10.1097/MCO.0b013e328365aae3
PG 8
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 247BA
UT WOS:000326586800020
PM 24071781
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Martocchia, A
   Gallucci, M
   Noale, M
   Maggi, S
   Cassol, M
   Stefanelli, M
   Postacchini, D
   Proietti, A
   Barbagallo, M
   Dominguez, LJ
   Ferri, C
   Desideri, G
   Toussan, L
   Pastore, F
   Falaschi, GM
   Paolisso, G
   Falaschi, P
AF Martocchia, A.
   Gallucci, M.
   Noale, M.
   Maggi, S.
   Cassol, M.
   Stefanelli, M.
   Postacchini, D.
   Proietti, A.
   Barbagallo, M.
   Dominguez, L. J.
   Ferri, C.
   Desideri, G.
   Toussan, L.
   Pastore, F.
   Falaschi, G. M.
   Paolisso, G.
   Falaschi, P.
CA AGICO Investigators
TI The cortisol burden in elderly subjects with metabolic syndrome and its
   association with low-grade inflammation
SO AGING CLINICAL AND EXPERIMENTAL RESEARCH
LA English
DT Article
DE Cortisol; Aging; Metabolic syndrome; Inflammation
ID COGNITIVE DECLINE; ADIPOSE-TISSUE; DEPRESSION; VALIDATION; MACARTHUR;
   EXCRETION; ILLNESS; STRESS; SCALE; FAT
AB Background Elderly people are exposed to an increased load of stressful events and neuro-hormonal stimulation is a key finding in metabolic syndrome and its related disorders.
   Aims To determine the role of cortisol in elderly subjects, with or without metabolic syndrome (MetS), by means of a national multicentre observational study, AGICO (AGIng and Cortisol).
   Methods From 2012 to 2017, the AGICO study enrolled n.339 subjects (aged>65), after obtaining their informed consent. The investigators assessed a cardio-metabolic panel (including electrocardiogram, carotid ultrasonography and echocardiography), the presence of MetS (on Adult Treatment Panel III criteria), a neurological examination (including brain imaging), and cortisol activity (using a consecutive collection of diurnal and nocturnal urine).
   Results In the patients presenting with MetS, the standardized diurnal and nocturnal cortisol excretion rates were 210.7145.5 and 173.7118.1 (mean +/- standard deviation) mu g/g creatinine/12 h; in those without MetS, the standardized diurnal and nocturnal cortisol excretion rates were 188.7 +/- 92.7 and 144.1 +/- 82.3 mu g/g creatinine/12 h, respectively (nocturnal urinary cortisol in patients with MetS versus those without MetS p=0.05, female patients with MetS vs female patients without MetS, p<0.025). A significant positive correlation was found between the CRP levels and both the diurnal and nocturnal urinary cortisol levels with r=0.187 (p<0.025) and r=0.411 (p<0.00000001), respectively.
   Discussion The elderly patients with MetS showed a trend towards increased standardized nocturnal cortisol excretions, with particular regard to the female subjects.
   Conclusion The positive correlation between cortisol excretion and low-grade inflammation suggests a common mechanism driving both hormonal and inflammatory changes.
C1 [Martocchia, A.; Stefanelli, M.; Proietti, A.; Toussan, L.; Pastore, F.; Falaschi, G. M.; Falaschi, P.] Sapienza Univ Rome, S Andrea Hosp, Via Grottarossa 1035, I-00189 Rome, Italy.
   [Gallucci, M.] Local Hlth Author 2, Cognit Impairment Ctr, Treviso, Italy.
   [Noale, M.; Maggi, S.] CNR, Neurosci Inst, Padua, Italy.
   [Cassol, M.] S Pietro Fatebenefratelli Hosp, Rome, Italy.
   [Postacchini, D.] Italian Natl Res Ctr Aging IRCCS INRCA, Fermo, Italy.
   [Barbagallo, M.; Dominguez, L. J.] Univ Palermo, Dept Internal Med & Geriatr, Palermo, Italy.
   [Ferri, C.; Desideri, G.] Univ Aquila, Laquila, Italy.
   [Paolisso, G.] Univ Campania L Vanvitelli, Dept Adv Med & Surg Sci, Naples, Italy.
C3 Sapienza University Rome; Azienda Ospedaliera Sant'Andrea; Consiglio
   Nazionale delle Ricerche (CNR); University of Palermo; University of
   L'Aquila; Universita della Campania Vanvitelli
RP Martocchia, A (corresponding author), Sapienza Univ Rome, S Andrea Hosp, Via Grottarossa 1035, I-00189 Rome, Italy.
EM a_martocchia@virgilio.it
RI Cecchini, Alberto/AAQ-9570-2021; Postacchini, Demetrio/AAB-6736-2020;
   paolisso, giuseppe/AAP-8516-2020; Martocchia, Antonio/GYU-9119-2022;
   Desideri, Giovambattista/AAB-5079-2022; Noale, Marianna/IXD-2540-2023;
   BARBAGALLO, MARIO/K-4794-2017; Barbieri, Michelangela/K-2192-2016;
   Giuli, Cinzia/K-1172-2016; Gallucci, Maurizio/K-1422-2018
OI Barbieri, Michelangela/0000-0002-9223-5792; Giuli,
   Cinzia/0000-0001-8826-2467; Gallucci, Maurizio/0000-0001-6329-3195;
   DESIDERI, Giovambattista/0000-0002-0145-1271; Noale,
   Marianna/0000-0001-7115-139X; Postacchini, Demetrio/0000-0001-5239-2702;
   Martocchia, Antonio/0000-0002-6201-5377; Santillo,
   Elpidio/0000-0001-8914-1317
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NR 25
TC 6
Z9 6
U1 0
U2 2
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1594-0667
EI 1720-8319
J9 AGING CLIN EXP RES
JI Aging Clin. Exp. Res.
PD JUL
PY 2020
VL 32
IS 7
BP 1309
EP 1315
DI 10.1007/s40520-019-01322-3
PG 7
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA NI2AO
UT WOS:000565158600018
PM 31471891
DA 2025-06-11
ER

PT J
AU Okubo, N
   Matsuzaka, M
   Takahashi, I
   Sawada, K
   Sato, S
   Akimoto, N
   Umeda, T
   Nakaji, S
AF Okubo, Noriyuki
   Matsuzaka, Masashi
   Takahashi, Ippei
   Sawada, Kaori
   Sato, Satoshi
   Akimoto, Naoki
   Umeda, Takashi
   Nakaji, Shigeyuki
CA Hirosaki Univ
TI Relationship between self-reported sleep quality and metabolic syndrome
   in general population
SO BMC PUBLIC HEALTH
LA English
DT Article
DE Metabolic syndrome; Obesity; Pittsburgh sleep quality index; Sleep
   quality; General population
ID CORONARY-HEART-DISEASE; RISK-FACTOR; DURATION; MORTALITY; ASSOCIATIONS;
   COMPONENTS
AB Background: To examine an association between self-reported sleep quality determined by Pittsburgh sleep quality index (PSQI) and metabolic syndrome.
   Methods: This study was designed as cross-sectional study. Participants were 1481 adults aged 20 years and above from general population (549 males and 932 females). We assessed the global sleep quality by PSQI. PSQI consists of 7 elements, i.e. subjective sleep quality, sleep latency (prolonged sleep onset time), sleep duration, habitual sleep efficiency (proportion of hours slept to hours spent in bed), sleep disturbance (interruption of sleep), use of sleep medication and daytime dysfunction (trouble staying awake while engaging in social activity). Any participants with score of 6 or more are diagnosed to have sleep disorder. We also assessed the above 7 elements, which consisted of a four-grade system (i.e. 0, 1, 2, 3). Metabolic syndrome consisted of abdominal obesity, hypertension, impaired glucose tolerance and dyslipidemia. Diagnosis of metabolic syndrome was done when the participants have abdominal obesity and meet two or more other components. All analyses were adjusted by age, drinking habit, smoking habit, working hours, exercise habit and depression.
   Results: Fifty-two male participants (9.5%) and 133 female (14.3%) scored 6 or more points in global PSQI score. The global PSQI score, sleep latency score and sleep disturbance score of participants with metabolic syndrome were higher level than those without the condition (p < 0.001, p = 0.009, p = 0.025 for male and p < 0.001, p < 0.001, p = 0.002 for females, respectively). The odds ratio of metabolic syndrome among participants with PSQI score of 6 or more points were 2.37 (95% confidence interval: 1.23-4.58) for males and 2.71 (1.45-5.07) for females in contrast to those with 5 or less points. The odds ratio of metabolic syndrome with sleep latency score of 2 was 2.65 (1.14-6.15) for male and 3.82 (1.81-8.09) for females in contrast with those of 0. The odds ratio of metabolic syndrome with sleep disturbance score of 1 was 1.76 (1.09-2.86) for males and 2.43 (1.26-4.69) for females in contrast with those of 0.
   Conclusions: Global PSQI score and its components (especially, sleep latency and sleep disturbance) were associated with metabolic syndrome.
C1 [Okubo, Noriyuki; Takahashi, Ippei; Sawada, Kaori; Sato, Satoshi; Akimoto, Naoki; Nakaji, Shigeyuki] Hirosaki Univ, Grad Sch Med, Dept Social Med, Hirosaki, Aomori 0368562, Japan.
   [Matsuzaka, Masashi] Hirosaki Univ, Grad Sch Med, Dept Med Informat, Hirosaki, Aomori 0368562, Japan.
   [Umeda, Takashi] Meijo Univ, Dept Fac Pharm, Tenpaku Ku, Nagoya, Aichi 4688503, Japan.
C3 Hirosaki University; Hirosaki University; Meijo University
RP Nakaji, S (corresponding author), Hirosaki Univ, Grad Sch Med, Dept Social Med, 5 Zaifu Cho, Hirosaki, Aomori 0368562, Japan.
EM nakaji@cc.hirosaki-u.ac.jp
FU Ministry of Education, Culture, Sports, Science and Technology (MEXT)
   [21792291]; Health Science Research Grant from the ministry of Health,
   Labour and Welfare of the Japanese Government [N20120199]; Grants-in-Aid
   for Scientific Research [21792291] Funding Source: KAKEN
FX We wish to express our gratitude to Takashi Ohida; MD, Yoshitaka
   Kaneita; MD (Department of Public Health, School of Medicine, Nihon
   University) and Miya Nishimura; PhD (Hirosaki University Graduate School
   of Health Sciences) for their generous help and support in this study.
   This study was supported by a Grant-in-Aid for Young Scientists from The
   Ministry of Education, Culture, Sports, Science and Technology (MEXT)
   (21792291) and a Health Science Research Grant from the ministry of
   Health, Labour and Welfare of the Japanese Government (N20120199).
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NR 29
TC 76
Z9 90
U1 0
U2 10
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2458
J9 BMC PUBLIC HEALTH
JI BMC Public Health
PD JUN 5
PY 2014
VL 14
AR 562
DI 10.1186/1471-2458-14-562
PG 7
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA AL2NY
UT WOS:000338963500008
PM 24903537
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Hintikka, J
   Lehto, SM
   Niskanen, L
   Huotari, A
   Herzig, KH
   Koivumaa-Honkanen, H
   Honkalampi, K
   Sinikallio, S
   Viinamäki, H
AF Hintikka, Jukka
   Lehto, Soili M.
   Niskanen, Leo
   Huotari, Anne
   Herzig, Karl-Heinz
   Koivumaa-Honkanen, Heli
   Honkalampi, Kirsi
   Sinikallio, Sanna
   Viinamaki, Heimo
TI Unemployment and ill health: a connection through inflammation?
SO BMC PUBLIC HEALTH
LA English
DT Article
ID BEAD ARRAY ASSAYS; CARE PROFESSIONALS; METABOLIC SYNDROME; DEPRESSION;
   CYTOKINES; CONSEQUENCES; SENSITIVITY; ADULTS; YOUNG; ELISA
AB Background: Unemployment is a source of acute and long-term psychosocial stress. Acute and chronic psychosocial stress can induce pronounced changes in human immune responses. In this study we tested our hypothesis that stress-induced low-grade tissue inflammation is more prevalent among the unemployed.
   Methods: We determined the inflammatory status of 225 general population subjects below the general retirement age (65 years in Finland). Those who had levels of both interleukin-6 (>= 0.97 pg/mL) and high-sensitivity C-reactive protein (>= 1.49 mg/L) above the median were assessed to have an elevated inflammatory status (n = 72).
   Results: An elevated inflammatory status was more common among the unemployed than among other study participants (59% versus 30%, p = 0.011). In the final multivariate model, those who were unemployed had over five-fold greater odds for having an elevated inflammatory status (OR 5.20, 95% CI 1.55-17.43, p = 0.008).
   Conclusion: This preliminary finding suggests that stress-induced low-grade inflammation might be a link between unemployment and ill health.
C1 [Hintikka, Jukka; Lehto, Soili M.; Honkalampi, Kirsi; Viinamaki, Heimo] Kuopio Univ Hosp, Dept Psychiat, FI-70210 Kuopio, Finland.
   [Hintikka, Jukka; Niskanen, Leo; Viinamaki, Heimo] Univ Kuopio, Dept Clin Med, FI-70210 Kuopio, Finland.
   [Niskanen, Leo] Kuopio Univ Hosp, Dept Med, FI-70210 Kuopio, Finland.
   [Huotari, Anne; Herzig, Karl-Heinz] Univ Oulu, Inst Biomed, Div Physiol, Oulu, Finland.
   [Huotari, Anne; Herzig, Karl-Heinz] Univ Oulu, Bioctr Oulu, Oulu, Finland.
   [Koivumaa-Honkanen, Heli] Univ Oulu, Dept Psychiat, Rovaniemi, Finland.
   [Koivumaa-Honkanen, Heli] Lapland Hosp Dist, Rovaniemi, Finland.
   [Sinikallio, Sanna] Kuopio Univ Hosp, Dept Rehabil, FI-70210 Kuopio, Finland.
C3 Kuopio University Hospital; University of Eastern Finland; University of
   Eastern Finland Hospital; University of Eastern Finland; University of
   Eastern Finland; University of Eastern Finland Hospital; Kuopio
   University Hospital; University of Oulu; University of Oulu; University
   of Oulu; University of Eastern Finland; University of Eastern Finland
   Hospital; Kuopio University Hospital
RP Hintikka, J (corresponding author), Kuopio Univ Hosp, Dept Psychiat, FI-70210 Kuopio, Finland.
EM jukka.hintikka@kuh.fi; soili.lehto@kuh.fi; leo.niskanen@kuh.fi;
   anne.maria.huotari@uef.fi; karl-heinz.herzig@oulu.fi;
   heli.koivumaa@kuh.fi; kirsi.honkalampi@kuh.fi; sanna.sinikallio@kuh.fi;
   heimo.viinamaki@kuh.fi
RI Koivumaa-Honkanen, Heli/L-1274-2015
OI Lehto, Soili/0000-0003-4324-6679
FU Annual EVO Financing
FX This study was supported by funding from the Annual EVO Financing. The
   researchers were independent from the funder.
CR [Anonymous], World Factb
   [Anonymous], STATEXTRACTS
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NR 27
TC 35
Z9 37
U1 0
U2 12
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-2458
J9 BMC PUBLIC HEALTH
JI BMC Public Health
PD NOV 12
PY 2009
VL 9
AR 410
DI 10.1186/1471-2458-9-410
PG 6
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA 525SF
UT WOS:000272235900002
PM 19909544
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Sharman, J
   Lim, R
   Marwick, T
AF Sharman, J. E.
   Lim, R.
   Marwick, T. H.
TI Cardiac syndrome X: relevance of arterial pressure waveform analysis to
   patients with chest pain and normal coronary arteries
SO JOURNAL OF HUMAN HYPERTENSION
LA English
DT Article
AB We report the case study of a 68-year-old female with cardiac syndrome X presenting with abnormal pressure waveforms and a hypertensive response to exercise with ST-segment depression. After amlodipine treatment, pressure waveform morphology was significantly improved, exercise testing was normal and symptoms had resolved. This case emphasizes the potential clinical value of arterial waveform analysis.
C1 Univ Queensland, Princess Alexandra Hosp, Dept Med, Brisbane, Qld, Australia.
   Univ Queensland, Sch Human Movement Studies, Brisbane, Qld, Australia.
   Univ Queensland, Princess Alexandra Hosp, Dept Cardiol, Brisbane, Qld, Australia.
C3 Princess Alexandra Hospital; University of Queensland; University of
   Queensland; University of Queensland; Princess Alexandra Hospital
RP Sharman, J (corresponding author), Univ Queensland, Princess Alexandra Hosp, Dept Med, Brisbane, Qld, Australia.
EM jsharman@soms.uq.edu.au
RI Marwick, Thomas/AAK-3869-2021; Lim, Richard/J-7102-2012; Sharman,
   James/B-2755-2009; Marwick, Thomas/C-7261-2013
OI Sharman, James/0000-0003-2792-0811; Marwick, Thomas/0000-0001-9065-0899
CR Kaski JC, 1999, DEV CARDIOVASC MED, V213, P1
NR 1
TC 3
Z9 3
U1 0
U2 0
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0950-9240
EI 1476-5527
J9 J HUM HYPERTENS
JI J. Hum. Hypertens.
PD JUN
PY 2006
VL 20
IS 6
BP 473
EP 474
DI 10.1038/sj.jhh.1002010
PG 2
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 044LI
UT WOS:000237673500016
PM 16554844
DA 2025-06-11
ER

PT J
AU Agnoletti, D
   Cicero, AFG
   Borghi, C
AF Agnoletti, Davide
   Cicero, Arrigo F. G.
   Borghi, Claudio
TI The Impact of Uric Acid and Hyperuricemia on Cardiovascular and Renal
   Systems
SO CARDIOLOGY CLINICS
LA English
DT Article
DE Uric acid; Hyperuricemia; Inflammation; Oxidative stress; Cardiovascular
   risk
ID CORONARY-HEART-DISEASE; ALL-CAUSE MORTALITY; METABOLIC SYNDROME;
   RISK-FACTOR; BLOOD-PRESSURE; HOMINOID EVOLUTION; KIDNEY-DISEASE;
   HYPERTENSION; PREDICTOR; LEVEL
C1 [Agnoletti, Davide] IRCCS Sacro Cuore Hosp, Internal Med Dept, Viale Luigi Rizzardi 4, Negrar Di Valpolicella, VR, Italy.
   [Cicero, Arrigo F. G.; Borghi, Claudio] Univ Bologna, Med & Surg Sci Dept, Via Albertoni 15, I-40138 Bologna, Italy.
C3 University of Bologna
RP Borghi, C (corresponding author), S Orsola Malpighi Univ Hosp, Via Albertoni 15, I-40138 Bologna, Italy.
EM claudio.borghi@unibo.it
RI Agnoletti, Davide/K-1441-2016
OI Cicero, Arrigo Francesco Giuseppe/0000-0002-4367-3884
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NR 103
TC 32
Z9 35
U1 1
U2 34
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0733-8651
EI 1558-2264
J9 CARDIOL CLIN
JI Cardiol. Clin.
PD AUG
PY 2021
VL 39
IS 3
BP 365
EP 376
DI 10.1016/j.ccl.2021.04.009
EA JUL 2021
PG 12
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA TH0AQ
UT WOS:000671757400007
PM 34247750
DA 2025-06-11
ER

PT J
AU Chandra, S
   Mondal, D
   Agrawal, KC
AF Chandra, Surabhi
   Mondal, Debasis
   Agrawal, Krishna C.
TI HIV-1 Protease Inhibitor Induced Oxidative Stress Suppresses Glucose
   Stimulated Insulin Release: Protection with Thymoquinone
SO EXPERIMENTAL BIOLOGY AND MEDICINE
LA English
DT Article
DE rat insulinoma cells (INS-1); HIV-1 protease inhibitors; insulin
   secretion; oxidative stress; thymoquinone
ID ACTIVE ANTIRETROVIRAL THERAPY; PORCINE CORONARY-ARTERIES; BETA-CELL
   DYSFUNCTION; NIGELLA-SATIVA OIL; POSTPRANDIAL HYPERGLYCEMIA; PERIPHERAL
   LIPODYSTROPHY; CARDIOVASCULAR RISK; DIABETES-MELLITUS; INFECTED
   PATIENTS; BODY-COMPOSITION
AB The highly active anti-retroviral therapy (HAART) regimen has considerably reduced the mortality rate in HIV-1 positive patients. However, long-term exposure to HAART is associated with a metabolic syndrome manifesting cardiovascular dysfunction, lipodystrophy, and insulin resistance syndrome (IRS). The inclusion of HIV-1 protease inhibitors (Pis) in HAART has been linked to the induction of IRS. Although several molecular mechanisms of PI-induced effects on insulin action have been postulated, the deleterious effects of Pis on insulin production by pancreatic beta-cells have not been fully investigated and therapeutic strategies to ameliorate insulin dysregulation at this level have not been targeted. The present study showed that exposure to several different Pis, nelfinavir (5-10 mu M), saquinavir (5-10 mu M) and atazanavir (8-20 mu M), decreases glucose stimulated insulin secretion from rat pancreatic beta-cells (INS-1). Nelfinavir significantly increased reactive oxygen species (ROS) generation and suppressed cytosolic, but not mitochondrial superoxide dismutase (SOD) levels. Nelfinvair also decreased both glutathione and ATP and increased UCP2 levels in these cells. Simultaneous treatment with thymoquinone (TO) (2.5 mu M), an active ingredient of black seed oil, significantly inhibited the effect of nelfinavir on augmented ROS production and suppressed SOD levels. Both TO and black seed oil exposure increased glucose stimulated insulin secretion and ameliorated the suppressive effect of nelfinavir. The present findings imply a direct role of ROS in PI induced deleterious effects on pancreatic beta-cells. Our findings also suggest that TO may be used as a potential therapeutic agent to normalize the dysregulated insulin production observed in HAART treated patients. Exp Biol Med 234:442-452, 2009
C1 [Agrawal, Krishna C.] Tulane Univ, Hlth Sci Ctr, Dept Pharmacol, Sch Med, New Orleans, LA 70112 USA.
C3 Tulane University
RP Agrawal, KC (corresponding author), Tulane Univ, Hlth Sci Ctr, Dept Pharmacol, Sch Med, 1430 Tulane Ave,St-83, New Orleans, LA 70112 USA.
EM agrawal@tulane.edu
FU NHLBI NIH HHS [1R01HL73691] Funding Source: Medline
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NR 58
TC 58
Z9 67
U1 0
U2 3
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1535-3702
EI 1535-3699
J9 EXP BIOL MED
JI Exp. Biol. Med.
PD APR
PY 2009
VL 234
IS 4
BP 442
EP 452
DI 10.3181/0811-RM-317
PG 11
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 430DU
UT WOS:000264969800010
PM 19234050
DA 2025-06-11
ER

PT J
AU Oliveira, LPM
   de Jesus, RP
   Boulhosa, RSSB
   Mendes, CMC
   Lyra, AC
   Lyra, LGC
AF Magalhaes Oliveira, Lucivalda Pereira
   de Jesus, Rosangela P.
   Boulhosa, Ramona S. S. B.
   Mendes, Carlos Mauricio C.
   Lyra, Andre Castro
   Lyra, Luiz Guilherme C.
TI Metabolic syndrome in patients with chronic hepatitis C virus genotype 1
   infection who do not have obesity or type 2 diabetes
SO CLINICS
LA English
DT Article
DE Metabolic Syndrome; Chronic Hepatitis C; Genotype 1; Overweight; Insulin
   Resistance
ID INSULIN-RESISTANCE; OXIDATIVE STRESS; LIVER; STEATOSIS; MORTALITY;
   FIBROSIS; DISEASE; RISK
AB OBJECTIVE: The individual components of metabolic syndrome may be independent predictors of mortality in patients with liver disease. We aimed to evaluate the prevalence of metabolic syndrome and its related components in hepatitis C virus-infected patients who are not obese and do not have type 2 diabetes.
   METHODS: This cross-sectional study included 125 patients infected with hepatitis C virus genotype 1. Metabolic syndrome was defined according to the International Diabetes Federation. Anthropometric data were measured according to standardized procedures. Bioimpedance analysis was performed on all patients.
   RESULTS: Metabolic syndrome was diagnosed in 21.6% of patients. Of the subjects with metabolic syndrome, 59.3% had hypertension, 77.8% had insulin resistance, 85.2% were overweight, 48.1% had a high waist circumference, 85.2% had an increased body fat percentage, and 92.3% had an elevated waist: hip ratio. In the bivariate analysis, female sex (OR 2.58; 95% CI: 1.09-6.25), elevated gamma-glutamyl transferase (cGT) (OR 2.63; 95% CI: 1.04-7.29), elevated fasting glucose (OR 8.05; 95% CI: 3.17-21.32), low HDL cholesterol (OR 2.80; 95% CI: 1.07-7.16), hypertriglyceridemia (OR 7.91; 95% CI: 2.88-22.71), elevated waist circumference (OR 10.33; 95% CI: 3.72-30.67), overweight (OR 11.33; 95% CI: 3.97-41.07), and increased body fat percentage (OR 8.34; 95% CI: 2.94-30.08) were independent determinants of metabolic syndrome. Using the final multivariate regression model, similar results were observed for abdominal fat (OR 9.98; 95% CI: 2.63-44.41) and total body fat percentage (OR 8.73; 95% CI: 2.33-42.34). However, metabolic syndrome risk was also high for those with blood glucose >= 5.55 mmol/L or HDL cholesterol <0.9 mmol/L (OR 16.69; 95% CI: 4.64-76.35; OR 7.23; 95% CI: 1.86-32.63, respectively).
   CONCLUSION: Metabolic syndrome is highly prevalent among hepatitis C virus-infected patients without type 2 diabetes or obesity. Metabolic syndrome was significantly associated with hypertension, insulin resistance, increased abdominal fat, and overweight.
C1 [Magalhaes Oliveira, Lucivalda Pereira; Boulhosa, Ramona S. S. B.; Mendes, Carlos Mauricio C.; Lyra, Andre Castro; Lyra, Luiz Guilherme C.] Univ Fed Bahia, Postgrad Program, Salvador, BA, Brazil.
   [Magalhaes Oliveira, Lucivalda Pereira; de Jesus, Rosangela P.] Univ Fed Bahia, Dept Nutr Sci, Salvador, BA, Brazil.
   [Lyra, Andre Castro] Univ Fed Bahia, Dept Med, Div Gastroenterol & Hepatol, Salvador, BA, Brazil.
   [Lyra, Andre Castro; Lyra, Luiz Guilherme C.] Hosp Sao Rafael, Gastrohepatol Unit, Salvador, BA, Brazil.
C3 Universidade Federal da Bahia; Universidade Federal da Bahia;
   Universidade Federal da Bahia
RP Oliveira, LPM (corresponding author), Univ Fed Bahia, Postgrad Program, Salvador, BA, Brazil.
EM valdapm@hotmail.com
RI Mendes, Carlos/AAC-1635-2019; Boulhosa, Ramona/KHX-2630-2024; Mendes,
   Carlos Mauricio Cardeal/R-3688-2017
OI , Lucivalda/0000-0003-4822-5930; Mendes, Carlos Mauricio
   Cardeal/0000-0003-2089-5668; Boulhosa, Ramona/0000-0001-7590-5793
CR Abdel-Azziz MY., 2010, ARAB J GASTROENTEROL, V11, P30, DOI [10.1016/j.ajg.2010.01.004, DOI 10.1016/J.AJG.2010.01.004]
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   [No title captured]
   [No title captured]
NR 28
TC 22
Z9 22
U1 0
U2 4
PU HOSPITAL CLINICAS, UNIV SAO PAULO
PI SAO PAULO
PA FAC MEDICINA, UNIV SAO PAULO, SAO PAULO, SP 00000, BRAZIL
SN 1807-5932
EI 1980-5322
J9 CLINICS
JI Clinics
PY 2012
VL 67
IS 3
BP 219
EP 223
DI 10.6061/clinics/2012(03)03
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 919WN
UT WOS:000302362900003
PM 22473401
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Mah, E
   Sapper, TN
   Chitchumroonchokchai, C
   Failla, ML
   Schill, KE
   Clinton, SK
   Bobe, G
   Traber, MG
   Bruno, RS
AF Mah, Eunice
   Sapper, Teryn N.
   Chitchumroonchokchai, Chureeporn
   Failla, Mark L.
   Schill, Kevin E.
   Clinton, Steven K.
   Bobe, Gerd
   Traber, Maret G.
   Bruno, Richard S.
TI α-Tocopherol bioavailability is lower in adults with metabolic syndrome
   regardless of dairy fat co-ingestion: a randomized, double-blind,
   crossover trial
SO AMERICAN JOURNAL OF CLINICAL NUTRITION
LA English
DT Article
DE alpha-tocopherol; bioavailability; metabolic syndrome; nonalcoholic
   steatohepatitis; pharmacokinetics
ID VITAMIN-E; PLASMA-LIPOPROTEINS; LIVER-DISEASE; CACO-2 CELLS;
   NONALCOHOLIC STEATOHEPATITIS; GLOBULE-MEMBRANE; UNITED-STATES; US
   ADULTS; MILK; ABSORPTION
AB Background: Increasing dietary fat intake is expected to improve alpha-tocopherol bioavailability, which could be beneficial for improving alpha-tocopherol status, especially in cohorts at high cardiometabolic risk who fail to meet dietary alpha-tocopherol requirements.
   Objective: Our objective was to assess dose-dependent effects of dairy fat and metabolic syndrome (MetS) health status on alpha-tocopherol pharmacokinetics in plasma and lipoproteins.
   Design: A randomized, crossover, double-blind study was conducted in healthy and MetS adults (n = 10/group) who ingested encapsulated hexadeuterium-labeled (d(6))-RRR-alpha-tocopherol (15 mg) with 240 mL nonfat (0.2 g fat), reduced-fat (4.8 g fat), or whole (7.9 g fat) milk before blood collection at regular intervals for 72 h.
   Results: Compared with healthy participants, those with MetS had lower (P < 0.05) baseline plasma alpha-tocopherol (mu mol/mmol lipid) and greater oxidized low-density lipoprotein (LDL), interleukin (IL)-6, IL-IL-10, and C-reactive protein. Regardless of health status, d(6)-alpha-tocopherol bioavailability was unaffected by increasing amounts of dairy fat provided by milk beverages, but MetS participants had lower estimated d(6)-alpha-tocopherol absorption (+/- SEM) than did healthy participants (26.1% +/- 1.0% compared with 29.5% +/- 1.1%). They also had lower plasma d(6)-alpha-tocopherol AUC from 0 to 72 h, as well as maximal concentrations (C-max: 2.04 +/- 0.14 compared with 2.73 +/- 0.18 mu mol/L) and slower rates of plasma disappearance but similar times to C-max. MetS participants had lower d(6)-alpha-tocopherol AUC from t = 0-12 h (AUC(0-t) (final)) 1 in lipoprotein fractions [chylomicron, very-low-density lipoprotein (VLDL), LDL, high-density lipoprotein]. Percentages of d(6)-alpha-tocopherol AUC(0-t) (final) in both the chylomicron (r = -0.46 to -0.52) and VLDL (r = -0.49 to -0.68) fractions were inversely correlated with oxidized LDL, IL-10, IL-6, and C-reactive protein.
   Conclusions: At dietary intakes equivalent to the Recommended Dietary Allowance, alpha-tocopherol bioavailability is unaffected by dairy fat quantity but is lower in MetS adults, potentially because of greater inflammation and oxidative stress that limits small intestinal alpha-tocopherol absorption and/or impairs hepatic alpha-tocopherol trafficking. These findings support higher dietary alpha-tocopherol requirements for MetS adults.
C1 [Mah, Eunice; Sapper, Teryn N.; Chitchumroonchokchai, Chureeporn; Failla, Mark L.; Schill, Kevin E.; Bruno, Richard S.] Ohio State Univ, Dept Human Sci, Human Nutr Program, Columbus, OH 43210 USA.
   [Clinton, Steven K.] Ohio State Univ, Dept Internal Med, Div Med Oncol, Columbus, OH 43210 USA.
   [Bobe, Gerd; Traber, Maret G.] Oregon State Univ, Linus Pauling Inst, Corvallis, OR 97331 USA.
C3 University System of Ohio; Ohio State University; University System of
   Ohio; Ohio State University; Oregon State University
RP Bruno, RS (corresponding author), Ohio State Univ, Dept Human Sci, Human Nutr Program, Columbus, OH 43210 USA.
EM bruno.27@osu.edu
RI Traber, Maret/ABI-2511-2020; Bruno, Richard/K-1930-2012
OI Bruno, Richard/0000-0002-6772-2038; Traber, Maret/0000-0002-2892-4024
FU National Dairy Council; National Center for Advancing Translational
   Sciences [UL1TR001070]
FX Supported by the National Dairy Council (to RSB) and the National Center
   for Advancing Translational Sciences (UL1TR001070). The National Dairy
   Council had no influence on the study design, implementation, data
   analysis, or interpretation regarding the conclusions of this study.
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NR 53
TC 59
Z9 64
U1 0
U2 11
PU AMER SOC NUTRITION-ASN
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0002-9165
EI 1938-3207
J9 AM J CLIN NUTR
JI Am. J. Clin. Nutr.
PD NOV
PY 2015
VL 102
IS 5
BP 1070
EP 1080
DI 10.3945/ajcn.115.118570
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA CV4YV
UT WOS:000364273300015
PM 26447154
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Kodydková, J
   Vávrová, L
   Zeman, M
   Jirák, R
   Macásek, J
   Stanková, B
   Tvrzická, E
   Zák, A
AF Kodydkova, Jana
   Vavrova, Lucie
   Zeman, Miroslav
   Jirak, Roman
   Macasek, Jaroslav
   Stankova, Barbora
   Tvrzicka, Eva
   Zak, Ales
TI Antioxidative enzymes and increased oxidative stress in depressive women
SO CLINICAL BIOCHEMISTRY
LA English
DT Article
DE Depressive disorder; Oxidative stress; Antioxidative enzymes; Conjugated
   dienes
ID MAJOR DEPRESSION; SUPEROXIDE-DISMUTASE; LIPID-PEROXIDATION; REACTIVE
   OXYGEN; GLUTATHIONE; OXIDASE; SUSCEPTIBILITY; COMORBIDITY; METABOLISM;
   DISORDERS
AB Objectives: To investigate the activities of the main antioxidative enzymes and oxidative stress in women with depressive disorder (DD).
   Methods: In 35 drug-naive women with DD and 35 age matched healthy women enzymes superoxide dismutase (CuZnSOD), catalase (CAT), glutathione peroxidase (GPX1), glutathione reductase (GR) and paraoxonase (PON1), concentrations of conjugated dienes (CD), reduced glutathione (GSH) and anthropometric and clinical data were investigated.
   Results: Women with DD were found to have decreased activities of GPX1 (p<0.05), decreased concentrations of GSH (p<0.05), and increased activities of GR (p<0.05), CuZnSOD (p<0.001), and concentrations of CD (p<0.05). Activity of GPX1 was positively correlated with concentration of GSH (p<0.05). Concentrations of CD were positively correlated with TG (p<0.01).
   Conclusion: Our set of depressive women was characterized by changes indicating an increased oxidative stress, as well as by certain features of metabolic syndrome. (C) 2009 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
C1 [Kodydkova, Jana; Vavrova, Lucie; Zeman, Miroslav; Macasek, Jaroslav; Stankova, Barbora; Tvrzicka, Eva; Zak, Ales] Charles Univ Prague, Fac Med 1, Dept Internal Med 4, Prague, Czech Republic.
   [Kodydkova, Jana; Vavrova, Lucie; Zeman, Miroslav; Macasek, Jaroslav; Stankova, Barbora; Tvrzicka, Eva; Zak, Ales] Gen Teaching Hosp, Prague, Czech Republic.
   [Jirak, Roman] Charles Univ Prague, Fac Med 1, Dept Psychiat, Prague, Czech Republic.
C3 Charles University Prague; General University Hospital Prague; General
   University Hospital Prague; Charles University Prague
RP Kodydková, J (corresponding author), U Nemocnice 2, Prague 12801 2, Czech Republic.
EM jana.kodydkova@seznam.cz
RI Vavrova, Lucie/D-7030-2017; Zeman, Miroslav/J-5281-2016; Zak,
   Ales/G-8318-2016; Rychlikova, Jana/A-2531-2015; Macasek,
   Jaroslav/G-8337-2016; Tvrzicka, Eva/Q-6300-2016; Stankova,
   Barbora/L-7933-2016; Jirak, Roman/O-1658-2017
OI Zeman, Miroslav/0000-0001-5338-603X; Zak, Ales/0000-0002-1698-6068;
   Rychlikova, Jana/0000-0002-6961-5260; Macasek,
   Jaroslav/0000-0002-8009-8970; Tvrzicka, Eva/0000-0003-0794-8454;
   Stankova, Barbora/0000-0002-6184-4878; Jirak, Roman/0000-0002-8061-9668
FU Ministry of Health, and research [IGA NR/8806-3]; Ministry of Education,
   Youth and Sports, Czech Republic [MSM0021620820]
FX This study was supported by the grant IGA NR/8806-3, Ministry of Health,
   and research project MSM0021620820, Ministry of Education, Youth and
   Sports, Czech Republic.
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NR 59
TC 151
Z9 159
U1 0
U2 14
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0009-9120
EI 1873-2933
J9 CLIN BIOCHEM
JI Clin. Biochem.
PD SEP
PY 2009
VL 42
IS 13-14
BP 1368
EP 1374
DI 10.1016/j.clinbiochem.2009.06.006
PG 7
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Medical Laboratory Technology
GA 526BF
UT WOS:000272261800006
PM 19527700
DA 2025-06-11
ER

PT J
AU de Kloet, AD
   Krause, EG
   Solomon, MB
   Flak, JN
   Scott, KA
   Kim, DH
   Myers, B
   Ulrich-Lai, YM
   Woods, SC
   Seeley, RJ
   Herman, JP
AF de Kloet, Annette D.
   Krause, Eric G.
   Solomon, Matia B.
   Flak, Jonathan N.
   Scott, Karen A.
   Kim, Dong-Hoon
   Myers, Brent
   Ulrich-Lai, Yvonne M.
   Woods, Stephen C.
   Seeley, Randy J.
   Herman, James P.
TI Adipocyte glucocorticoid receptors mediate fat-to-brain signaling
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE Hypothalamic-pituitary-adrenal axis; Corticosterone; Adipose; Obesity;
   Stress
ID ADRENAL AXIS ACTIVITY; CHRONIC STRESS; METABOLIC SYNDROME; ABDOMINAL
   OBESITY; BROWN ADIPOCYTES; GENE-EXPRESSION; ANGIOTENSIN-II;
   ADIPOSE-TISSUE; FOOD-INTAKE; HPA-AXIS
AB Stress-related (e.g., depression) and metabolic pathologies (e.g., obesity) are important and often co-morbid public health concerns. Here we identify a connection between peripheral glucocorticoid receptor (GR) signaling originating in fat with the brain control of both stress and metabolism. Mice with reduced adipocyte GR hypersecrete glucocorticoids following acute psychogenic stress and are resistant to diet-induced obesity. This hypersecretion gives rise to deficits in responsiveness to exogenous glucocorticoids, consistent with reduced negative feedback via adipocytes. Increased stress reactivity occurs in the context of elevated hypothalamic expression of hypothalamic-pituitary-adrenal (HPA) axis-excitatory neuropeptides and in the absence of altered adrenal sensitivity, consistent with a central cite of action. Our results identify a novel mechanism whereby activation of the adipocyte GR promotes peripheral energy storage while inhibiting the HPA axis, and provide functional evidence for a fat-to-brain regulatory feedback network that serves to regulate not just homeostatic energy balance but also responses to psychogenic stimuli. (C) 2015 Elsevier Ltd. All rights reserved.
C1 [de Kloet, Annette D.; Solomon, Matia B.; Flak, Jonathan N.; Scott, Karen A.; Myers, Brent; Ulrich-Lai, Yvonne M.; Woods, Stephen C.; Herman, James P.] Univ Cincinnati, Coll Med, Dept Psychiat & Behav Neurosci, Cincinnati, OH 45237 USA.
   [de Kloet, Annette D.; Flak, Jonathan N.; Scott, Karen A.] Univ Cincinnati, Grad Program Neurosci, Cincinnati, OH 45237 USA.
   [de Kloet, Annette D.] Univ Florida, Coll Med, Dept Physiol & Funct Genom, Gainesville, FL 32611 USA.
   [Krause, Eric G.] Univ Florida, Coll Pharm, Dept Pharmacodynam, Gainesville, FL 32610 USA.
   [Kim, Dong-Hoon] Korea Univ, Coll Med, Dept Pharmacol, Seoul 136705, South Korea.
   [Seeley, Randy J.] Univ Michigan, Sch Med, Dept Surg, Ann Arbor, MI 48109 USA.
C3 University System of Ohio; University of Cincinnati; University System
   of Ohio; University of Cincinnati; State University System of Florida;
   University of Florida; State University System of Florida; University of
   Florida; Korea University; Korea University Medicine (KU Medicine);
   University of Michigan System; University of Michigan
RP de Kloet, AD (corresponding author), Univ Florida, Coll Med, McKnight Brain Inst, Physiol & Funct Genom, 100 S Newell Dr,Bldg 59,RM L4-162, Gainesville, FL 32611 USA.
EM adekloet@ufl.edu; james.herman@uc.edu
RI Herman, James/D-4960-2015; Kim, Sung/F-7292-2013; Solomon,
   Matia/KQV-0178-2024
OI Scott, Karen/0000-0002-4133-423X; Krause, Eric/0000-0002-2718-3113;
   Seeley, Randy/0000-0002-3721-5625; de Kloet, Annette/0000-0002-7213-6957
FU NIH [MH069860, MH049698, HL096830, NS068122]; National Institute of
   Diabetes and Digestive and Kidney Diseases [P30DK020572] Funding Source:
   NIH RePORTER
FX The present studies were funded by NIH grants, MH069860, MH049698,
   HL096830 and NS068122. The funding source had no involvement in the
   study design; in the collection, analysis and interpretation of data; in
   the writing of the report; and in the decision to submit the article for
   publication.
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NR 51
TC 34
Z9 36
U1 0
U2 15
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD JUN
PY 2015
VL 56
BP 110
EP 119
DI 10.1016/j.psyneuen.2015.03.008
PG 10
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA CH6JE
UT WOS:000354142100012
PM 25808702
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Seda, O
   Sedová, L
   Oliyarnyk, O
   Kazdová, L
   Krenová, D
   Corbeil, G
   Hamet, P
   Tremblay, J
   Kren, V
AF Seda, Ondrej
   Sedova, Lucie
   Oliyarnyk, Olena
   Kazdova, Ludmila
   Krenova, Drahomira
   Corbeil, Gilles
   Hamet, Pavel
   Tremblay, Johanne
   Kren, Vladimir
TI Pharmacogenomics of metabolic effects of rosiglitazone
SO PHARMACOGENOMICS
LA English
DT Article
DE animal models; insulin resistance; insulin sensitizer; microarray;
   oxidative stress; rosiglitazone
ID ACTIVATED-RECEPTOR-GAMMA; INSULIN-RESISTANCE SYNDROME; CONTROLLED-TRIAL;
   GENE-EXPRESSION; ADIPOSE-TISSUE; AGONIST ROSIGLITAZONE;
   DIABETES-MELLITUS; GLUCOSE-TOLERANCE; CONGENIC STRAINS; MOUSE MODELS
AB Introduction: Thiazolidinediones are increasingly used drugs for the treatment of Type 2 diabetes. The individual response to thiazolidinedione therapy, ranging from the variable degree of metabolic improvement to harmful side-effects, is empirical, yet the underlying mechanisms remain elusive. In order to assess the pharmacogenomic component of thiazolidinediones' metabolic action, we compared the effect of rosiglitazone in two genetically defined models of metabolic syndrome, polydactylous (PD) and BN.SHR4 inbred rat strains, with their insulin-sensitive, normolipidemic counterpart, the Brown Norway (BN) rat. Materials & Methods: 5-month-old male rats were fed a high-fat diet for 4 weeks, and the experimental groups received rosiglitazone (0.4 mg/100 g body weight) during the last 2 weeks of high-fat diet feeding. We assessed metabolic and morphometric profiles, oxidative stress parameters and gene expression in white adipose tissue.
   Results: In many followed parameters, we observed genetic background-specific effects of rosiglitazone administration. The mass and the sensitivity of visceral adipose tissue to insulin-stimulated lipogenesis increased with rosiglitazone treatment only in PD, correlating with a PD-specific significant increase in expression of prostaglandin D2 synthase. The glucose tolerance was enhanced in all strains, although fasting plasma glucose was increased by rosiglitazone in BN and BN.SHR4. Among the markers of lipid peroxidation, we observed the rosiglitazone-driven increase of plasma-conjugated dienes only in BN.SHR4. The genes with genotype-specific expression change included ADAM metallopeptidase domain 7, aquaporin 9, carnitine palmitoyltransferase 113, caveolin 1, catechol-O-methyl transferase, leptin and prostaglandin D2 synthase 2.
   Conclusion: Rosiglitazone's effects on lipid deposition and insulin sensitivity of peripheral tissues are largely dependent on the genetic background it acts upon.
C1 [Seda, Ondrej; Corbeil, Gilles; Hamet, Pavel; Tremblay, Johanne] Ctr Hosp Univ Montreal, Ctr Rech, Montreal, PQ H1W 4A4, Canada.
   [Seda, Ondrej; Sedova, Lucie; Krenova, Drahomira; Kren, Vladimir] Charles Univ Prague, Inst Biol & Med Genet, Fac Med 1, Prague, Czech Republic.
   [Seda, Ondrej; Sedova, Lucie; Krenova, Drahomira; Kren, Vladimir] Gen Teaching Hosp, Prague, Czech Republic.
   [Seda, Ondrej; Oliyarnyk, Olena; Kazdova, Ludmila] Inst Clin & Expt Med, Dept Metab & Diabet, Prague, Czech Republic.
C3 Universite de Montreal; Charles University Prague; General University
   Hospital Prague; Institute for Clinical & Experimental Medicine (IKEM)
RP Tremblay, J (corresponding author), Ctr Hosp Univ Montreal, Ctr Rech, Technopole Angus,2901 Rachel E,Off 314, Montreal, PQ H1W 4A4, Canada.
EM johanne.tremblay@umontreal.ca
RI Oliyarnyk, Olena/Q-6380-2019; Tremblay, Johanne/E-2154-2013; Seda,
   Ondrej/A-2058-2008; Sedova, Lucie/D-1089-2017
OI Seda, Ondrej/0000-0001-8498-5895; Sedova, Lucie/0000-0003-3783-2946;
   Oliyarnyk, Olena/0000-0002-4912-6187
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NR 71
TC 18
Z9 19
U1 0
U2 9
PU FUTURE MEDICINE LTD
PI LONDON
PA UNITEC HOUSE, 3RD FLOOR, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON, N3
   1QB, ENGLAND
SN 1462-2416
EI 1744-8042
J9 PHARMACOGENOMICS
JI Pharmacogenomics
PD FEB
PY 2008
VL 9
IS 2
BP 141
EP 155
DI 10.2217/14622416.9.2.141
PG 15
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 331DO
UT WOS:000257993100002
PM 18370844
DA 2025-06-11
ER

PT J
AU Basu, T
   Selman, A
   Reddy, AP
   Reddy, PH
AF Basu, Tanisha
   Selman, Ashley
   Reddy, Arubala P.
   Reddy, P. Hemachandra
TI Current Status of Obesity: Protective Role of Catechins
SO ANTIOXIDANTS
LA English
DT Review
DE obesity; mitochondrial dysfunction; hormonal deregulation;
   anti-inflammatory; antioxidant
ID HIGH-FAT DIET; GREEN TEA POLYPHENOL; ONION PEEL EXTRACT; ADIPOSE-TISSUE;
   OXIDATIVE STRESS; METABOLIC SYNDROME; MITOCHONDRIAL DYSFUNCTION;
   ENERGY-EXPENDITURE; BODY-WEIGHT; EPIGALLOCATECHIN GALLATE
AB Obesity is a growing health concern in today's society. Current estimates indicate that obesity occurs in both adults and young people. Recent research also found that the Hispanic population in the U.S. is 1.9 times more likely to be overweight as compared to their non-Hispanic population. Obesity is a multifactorial disease that has a variety of causes. All current treatment options incorporate dietary changes aimed at establishing a negative energy balance. According to current scientific research, multiple factors are involved with the development of obesity, including genetic, biochemical, psychological, environmental, behavioral, and socio-demographic factors. The people who suffer from obesity are far more likely to suffer serious health problems, such as stroke, diabetes, lung disease, bone and joint disease, cancer, heart disease, neurological disorders, and poor mental health. Studies indicate that multiple cellular changes are implicated in the progression of obesity, mitochondrial dysfunction, deregulated microRNAs, inflammatory changes, hormonal deregulation, and others. This article highlights the role that oxidative stress plays in obesity and current obesity-prevention techniques with an emphasis on the impact of catechins to prevent and treat obesity.
C1 [Basu, Tanisha; Selman, Ashley; Reddy, P. Hemachandra] Texas Tech Univ Hlth Sci Ctr, Dept Internal Med, Lubbock, TX 79430 USA.
   [Reddy, Arubala P.; Reddy, P. Hemachandra] Texas Tech Univ, Coll Human Sci, Nutr Sci Dept, Lubbock, TX 79409 USA.
   [Reddy, P. Hemachandra] Texas Tech Univ Hlth Sci Ctr, Neurol Dept, Sch Med, Lubbock, TX 79430 USA.
   [Reddy, P. Hemachandra] Texas Tech Univ Hlth Sci Ctr, Grad Sch Biomed Sci, Publ Hlth Dept, Lubbock, TX 79430 USA.
   [Reddy, P. Hemachandra] Texas Tech Univ Hlth Sci Ctr, Sch Hlth Profess, Dept Speech Language & Hearing Sci, Lubbock, TX 79430 USA.
C3 Texas Tech University System; Texas Tech University Health Sciences
   Center Lubbock; Texas Tech University System; Texas Tech University;
   Texas Tech University System; Texas Tech University Health Sciences
   Center Lubbock; Texas Tech University System; Texas Tech University
   Health Sciences Center Lubbock; Texas Tech University System; Texas Tech
   University Health Sciences Center Lubbock
RP Reddy, PH (corresponding author), Texas Tech Univ Hlth Sci Ctr, Dept Internal Med, Lubbock, TX 79430 USA.; Reddy, PH (corresponding author), Texas Tech Univ, Coll Human Sci, Nutr Sci Dept, Lubbock, TX 79409 USA.; Reddy, PH (corresponding author), Texas Tech Univ Hlth Sci Ctr, Neurol Dept, Sch Med, Lubbock, TX 79430 USA.; Reddy, PH (corresponding author), Texas Tech Univ Hlth Sci Ctr, Grad Sch Biomed Sci, Publ Hlth Dept, Lubbock, TX 79430 USA.; Reddy, PH (corresponding author), Texas Tech Univ Hlth Sci Ctr, Sch Hlth Profess, Dept Speech Language & Hearing Sci, Lubbock, TX 79430 USA.
EM hemachandra.reddy@ttuhsc.edu
OI Basu, Tanisha/0000-0001-7012-1148; Reddy, Arubala/0000-0003-0452-9553;
   Reddy, P. Hemachandra/0000-0002-9560-9948
FU NIH [AG063162, AG071560, NS205473, AG060767, AG069333, AG066347,
   AG079264]; Alzheimer's Association through a SAGA; Garrison Family
   Foundation Grant
FX The research presented in this article was supported by NIH grants
   AG042178, AG047812, NS205473, AG060767, AG069333, AG066347, and AG079264
   (to PHR), Alzheimer's Association through a SAGA grant, Garrison Family
   Foundation Grant and NIH grants AG063162 and AG071560 (to APR).
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NR 134
TC 20
Z9 21
U1 3
U2 51
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD FEB
PY 2023
VL 12
IS 2
AR 474
DI 10.3390/antiox12020474
PG 21
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA 9H2DW
UT WOS:000938648900001
PM 36830032
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Happell, B
   Platania-Phung, C
   Webster, S
   McKenna, B
   Millar, F
   Stanton, R
   Galletly, C
   Castle, D
   Furness, T
   Liu, D
   Scott, D
AF Happell, Brenda
   Platania-Phung, Chris
   Webster, Stephanie
   McKenna, Brian
   Millar, Freyja
   Stanton, Robert
   Galletly, Cherrie
   Castle, David
   Furness, Trentham
   Liu, Dennis
   Scott, David
TI Applying the World Health Organization Mental Health Action Plan to
   evaluate policy on addressing co-occurrence of physical and mental
   illnesses in Australia
SO AUSTRALIAN HEALTH REVIEW
LA English
DT Article
DE inequality; service evaluation
ID SMOKING-CESSATION INTERVENTION; INDUCED WEIGHT-GAIN; METABOLIC SYNDROME;
   RISK-FACTORS; PSYCHOTIC DISORDERS; CIGARETTE-SMOKING; CHRONIC DISEASES;
   NATIONAL-SURVEY; PEOPLE; CARE
AB Objectives. The aim of the present study was to document Australian policies on the physical health of people with mental illness and evaluate the capacity of policy to support health needs.
   Methods. A search of state and federal policies on mental and physical illness was conducted, as well as detailed analysis of policy content and the relationships between policies, by applying the World Health Organization Mental Health Action Plan 2013-2020 as an evaluative framework.
   Results. National policy attention to the physical health of people with mental illness has grown, but there is little interconnection at the national and state levels. State policies across the country are inconsistent, and there is little evidence of consistent policy implementation.
   Conclusions. A coherent national health policy framework on addressing co-occurring physical and mental illnesses that includes healthcare system reforms and ensuring the interconnectedness of other relevant services should be prioritised.
C1 [Happell, Brenda; Platania-Phung, Chris] Univ Canberra, Canberra Hosp, Res Ctr Nursing & Midwifery Practice, Fac Health, Woden, ACT 2606, Australia.
   [Happell, Brenda; Platania-Phung, Chris] Canberra Hosp, Res Ctr Nursing & Midwifery Practice, ACT Hlth, Woden, ACT 2606, Australia.
   [McKenna, Brian; Furness, Trentham] Australian Catholic Univ, Sch Nursing Midwifery & Paramed, Fitzroy, Vic 3065, Australia.
   [McKenna, Brian; Furness, Trentham] Royal Melbourne Hosp, NorthWestern Mental Hlth, Parkville, Vic 3050, Australia.
   [Millar, Freyja] Eastern Hlth, Melbourne, Vic 3128, Australia.
   [Stanton, Robert] Cent Queensland Univ, Sch Med & Appl Sci, Rockhampton, Qld 4700, Australia.
   [Galletly, Cherrie] Univ Adelaide, Sch Med, Adelaide, SA 5000, Australia.
   [Castle, David] St Vincents Hosp, Fitzroy, Vic 3065, Australia.
   [Liu, Dennis] Northern Mental Hlth Serv, Salisbury, SA 5108, Australia.
   [Scott, David] Sunshine Hosp, NorthWest Acad Ctr, St Albans, Vic 3021, Australia.
C3 Australian National University; Canberra Hospital; University of
   Canberra; ACT Health Australia; Australian National University; Canberra
   Hospital; Australian Catholic University; Melbourne Health; Royal
   Melbourne Hospital; Eastern Health; Central Queensland University;
   University of Adelaide; NSW Health; St Vincents Hospital Sydney; St
   Vincent's Health; St Vincent's Hospital Melbourne; Western Health;
   Sunshine Hospital
RP Happell, B (corresponding author), Univ Canberra, Canberra Hosp, Res Ctr Nursing & Midwifery Practice, Fac Health, Bldg 6,Level 3,POB 11, Woden, ACT 2606, Australia.
EM brenda.happell@canberra.edu.au; Brian.McKenna@mh.org.au;
   freyja.millar@easternhealth.org.au; r.stanton@cqu.edu.au;
   cherrie.galletly@adelaide.edu.au; David.CASTLE@svhm.org.au;
   Trentham.Furness@mh.org.au; Dennis.Liu@health.sa.gov.au;
   d.scott@unimelb.edu.au
RI Stanton, Rob/AAJ-5157-2020; Scott, David/AAE-5031-2021; Happell,
   Brenda/HSI-0570-2023; Furness, Trentham/N-8563-2016
OI Happell, Brenda/0000-0002-7293-6583; Scott, David/0000-0001-5226-1972;
   Furness, Trentham/0000-0002-3526-1687; Castle, David/0000-0002-3075-1580
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NR 96
TC 11
Z9 11
U1 0
U2 11
PU CSIRO PUBLISHING
PI CLAYTON
PA UNIPARK, BLDG 1, LEVEL 1, 195 WELLINGTON RD, LOCKED BAG 10, CLAYTON, VIC
   3168, AUSTRALIA
SN 0156-5788
EI 1449-8944
J9 AUST HEALTH REV
JI Aust. Health Rev.
PY 2015
VL 39
IS 4
BP 370
EP 378
DI 10.1071/AH14098
PG 9
WC Health Care Sciences & Services; Health Policy & Services
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services
GA CQ5QP
UT WOS:000360660800003
PM 25751505
OA Green Submitted, Bronze
DA 2025-06-11
ER

PT J
AU Sanchez-Barajas, M
   Ibarra-Reynoso, LDR
   Ayala-Garcia, MA
   Malacara, JM
AF Sanchez-Barajas, Mauricio
   del Rocio Ibarra-Reynoso, Lorena
   Antonio Ayala-Garcia, Marco
   Manuel Malacara, Juan
TI Flow mediated vasodilation compared with carotid intima media thickness
   in the evaluation of early cardiovascular damage in menopausal women and
   the influence of biological and psychosocial factors
SO BMC WOMENS HEALTH
LA English
DT Article
DE Menopause; Cardiovascular risk; Flow-mediated vasodilation; Carotid
   intima media thickness; Heart rate variability; Submission
ID HEART-RATE-VARIABILITY; R-R INTERVALS; RISK-FACTORS; ENDOTHELIAL
   DYSFUNCTION; METABOLIC SYNDROME; POLAR S810; DILATION; ATHEROSCLEROSIS;
   PREMENOPAUSAL; DEPRESSION
AB Background: Women after menopause increase risk for cardiovascular disease and several factors may be related. The purpose was to study biological and psychosocial factors associated with early cardiovascular damage in pre- and postmenopausal women, assessed with carotid intima-media thickness vs flow-mediated dilatation.
   Methods: Women 45 to 57 years old were grouped in the pre (n = 60), early (n = 58) and late post-menopause (n = 59). Anthropometric, metabolic and hormonal data were registered, as well as measures of depression, anxiety, submission, perceived stress, and sleep alterations. Heart Rate Variability was recorded to obtain the information regarding sympathovagal balance. Carotid intima-media thickness and flow-mediated dilatation were assessed by ultrasound. Two-way ANOVA and multiple regression model were used.
   Results: At late postmenopause, the carotid intima-media was thicker (p < 0.001) and flow-mediated dilatation decreased (p < 0.001). Carotid intima-media thickness was associated positively with age (p < 0.001), submission score (p = 0.029), follicle stimulating hormone levels (p < 0.001), and body mass index (p = 0.009). Flow-mediated dilatation was associated only with age (p < 0.001). Regarding heart rate variability, the time domain pNN50 measurement was higher in premenopausal women (p = 0.001), Low Frequency (LF) was higher in the two groups of postmenopausal (p = 0.001) and High Frequency (HF) higher in the early postmenopausal women (p = 0.042).
   Conclusions: Under our conditions carotid intima-media thickness had higher predictive value for early cardiovascular damage at menopause. The finding of the association of the submission score, indicates de influence of stress on vascular damage.
C1 [Sanchez-Barajas, Mauricio] Inst Mexicano Seguro Social, Dept Internal Med, Gen Hosp Zone MF 21, Guanajuato, Mexico.
   [Sanchez-Barajas, Mauricio; del Rocio Ibarra-Reynoso, Lorena; Manuel Malacara, Juan] Univ Guanajuato, Dept Med Sci, Leon Campus, Leon, Gto, Spain.
   [Antonio Ayala-Garcia, Marco] Inst Mexicano Seguro Social, Dept Gen Surg, Gen Hosp Subzone 10, Guanajuato, Mexico.
C3 Instituto Mexicano del Seguro Social; Instituto Mexicano del Seguro
   Social
RP Malacara, JM (corresponding author), Univ Guanajuato, Dept Med Sci, Leon Campus, Leon, Gto, Spain.
EM jmmalacara@hotmail.com
RI del Rocio Ibarra-Reynoso, Lorena/AAR-9678-2021; García,
   Marco/AAJ-1870-2021
OI Ibarra- Reynoso, Lorena del Rocio/0000-0002-6119-1328; Malacara, Juan
   Manuel/0000-0001-9150-9088; Ayala Garcia, Marco
   Antonio/0000-0001-6603-1799
FU Mexican National Council for Science and Technology (CONACYT) [242065]
FX This work was supported by the Mexican National Council for Science and
   Technology (CONACYT), grant number 242065 of JMM.
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NR 53
TC 6
Z9 7
U1 0
U2 5
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1472-6874
J9 BMC WOMENS HEALTH
JI BMC Womens Health
PD SEP 20
PY 2018
VL 18
AR 153
DI 10.1186/s12905-018-0648-3
PG 10
WC Public, Environmental & Occupational Health; Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; Obstetrics & Gynecology
GA GU3TL
UT WOS:000445202600001
PM 30236100
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Yan, CY
   Wang, H
   Liu, CX
   Fu, JM
   Zhou, YB
AF Yan, Chunyu
   Wang, He
   Liu, Changxing
   Fu, Jiamei
   Zhou, Yabin
TI Association between non-high-density lipoprotein cholesterol to
   high-density lipoprotein cholesterol ratio (NHHR) with depressive
   symptoms: recent findings from NHANES 2005-2018
SO FRONTIERS IN PSYCHIATRY
LA English
DT Article
DE NHHR; depression; NHANES; US adults; cross-sectional study
ID METABOLIC SYNDROME; SERUM; STRESS; HEALTH; VOLUME
AB Background: The ratio of non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol (NHHR) index is a relatively new composite lipid index, the relationship between NHHR and depression is unclear from the current study. The primary aim of our study was to examine the association between the prevalence of depression and NHHR in a US population. Methods: The National Health and Nutrition Examination Survey (NHANES) provided the data for our investigation from 2005 to 2018. and primarily included participants who contained complete data on NHHR and depression in U.S. adults (age >= 20 years). Associations between NHHR and depression were assessed using multifactorial logistic regression analysis, subgroup analysis, and smoothed curve fitting. Results: In our study, 29,561 subjects in total showed a mean NHHR index of 3.12 +/- 1.58,A noteworthy positive correlation was observed between NHHR and depression in multifactorial logistic regression analysis. Subgroup analyses and tests of interaction showed that gender, age, ethnicity, PIR, smoking, alcohol consumption, coronary heart disease, diabetes mellitus, hypertension, and stroke did not influence the NHHR and the association between depression (P for interaction > 0.05), whereas two stratification factors, BMI and sleep disturbance, may be potential factors in the association between NHHR and depression (P for interaction < 0.05). Conclusion: According to our present study, if the level of NHHR rises in American adults, their likelihood of developing depression also increases.
C1 [Yan, Chunyu] Heilongjiang Univ Tradit Chinese Med, Clin Med Coll 1, Harbin, Peoples R China.
   [Wang, He; Liu, Changxing; Fu, Jiamei; Zhou, Yabin] Heilongjiang Univ Tradit Chinese Med, Affiliated Hosp 1, Dept Cardiol, Harbin, Peoples R China.
C3 Heilongjiang University of Chinese Medicine; Heilongjiang University of
   Chinese Medicine
RP Zhou, YB (corresponding author), Heilongjiang Univ Tradit Chinese Med, Affiliated Hosp 1, Dept Cardiol, Harbin, Peoples R China.
EM 15164636688@163.com
RI Liu, Changxing/HLQ-5208-2023; Liu, Changxing/LXW-5129-2024
OI Liu, Changxing/0000-0001-9900-9862
FX The author(s) declare that no financial support was received for the
   research, authorship, and/or publication of this article.
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NR 42
TC 0
Z9 0
U1 16
U2 16
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-0640
J9 FRONT PSYCHIATRY
JI Front. Psychiatry
PD NOV 5
PY 2024
VL 15
AR 1467142
DI 10.3389/fpsyt.2024.1467142
PG 9
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA M6Q0X
UT WOS:001358750700001
PM 39564464
OA Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Tremblay-Franco, M
   Zerbinati, C
   Pacelli, A
   Palmaccio, G
   Lubrano, C
   Ducheix, S
   Guillou, H
   Iuliano, L
AF Tremblay-Franco, Marie
   Zerbinati, Chiara
   Pacelli, Antonio
   Palmaccio, Giuseppina
   Lubrano, Carla
   Ducheix, Simon
   Guillou, Herve
   Iuliano, Luigi
TI Effect of obesity and metabolic syndrome on plasma oxysterols and fatty
   acids in human
SO STEROIDS
LA English
DT Article
DE Oxysterols; Fatty acids; Metabolic syndrome; Obesity; Diabetes; Lipid
   metabolism
ID LIVER X RECEPTORS; CHOLESTEROL OXIDATION; LXR-ALPHA; GENE;
   4-BETA-HYDROXYCHOLESTEROL; PRODUCTS; SREBP-1C; STRESS
AB Background: Obesity and the related entity metabolic syndrome are characterized by altered lipid metabolism and associated with increased morbidity risk for cardiovascular disease and cancer. Oxysterols belong to a large family of cholesterol-derived molecules known to play crucial role in many signaling pathways underlying several diseases. Little is known on the potential effect of obesity and metabolic syndrome on oxysterols in human.
   Objectives: In this work, we questioned whether circulating oxysterols might be significantly altered in obese patients and in patients with metabolic syndrome. We also tested the potential correlation between circulating oxysterols and fatty acids.
   Methods: 60 obese patients and 75 patients with metabolic syndrome were enrolled in the study along with 210 age- and sex-matched healthy subjects, used as control group. Plasma oxysterols were analyzed by isotope dilution GC/MS, and plasma fatty acids profiling was assessed by gas chromatography coupled with flame ionization detection.
   Results: We found considerable differences in oxysterols profiling in the two disease groups that were gender-related. Compared to controls, males showed significant differences only in 4 alpha- and 4 beta-hydroxycholesterol levels in obese and metabolic syndrome patients. In contrast, females showed consistent differences in 7-oxocholesterol, 4 alpha-hydroxycholesterol, 25-hydroxycholesterol and triol. Concerning fatty acids, we found minor differences in the levels of these variables in males of the three groups. Significant changes were observed in plasma fatty acid profile of female patients with obesity or metabolic syndrome. We found significant correlations between various oxysterols and fatty acids. In particular, 4 beta-hydroxycho1esterol, which is reduced in obesity and metabolic syndrome, correlated with a number of saturated and mono-unsaturated fatty acids that are end-products of de novo lipogenesis.
   Conclusions: Our data provide the first evidence that obesity and metabolic syndrome are associated with major, gender-specific, changes in circulating oxysterols and fatty acids. These findings suggest a metabolic link between oxysterols and fatty acids, and that oxysterols may contribute to the epidemic diseases associated with obesity and metabolic syndrome in female. (C) 2015 Elsevier Inc. All rights reserved.
C1 [Tremblay-Franco, Marie; Ducheix, Simon; Guillou, Herve] INRA, ToxAlim, Res Ctr Food Toxicol, UMR1331, F-31931 Toulouse, France.
   [Zerbinati, Chiara; Pacelli, Antonio; Palmaccio, Giuseppina; Iuliano, Luigi] Univ Roma La Sapienza, Dept Med Surg Sci & Biotechnol, I-04100 Latina, Italy.
   [Lubrano, Carla] Univ Roma La Sapienza, Dept Expt Med, Rome, Italy.
C3 INRAE; Universite Federale Toulouse Midi-Pyrenees (ComUE); Universite de
   Toulouse; Institut National Polytechnique de Toulouse; Universite
   Toulouse III - Paul Sabatier; Sapienza University Rome; Sapienza
   University Rome
RP Iuliano, L (corresponding author), Univ Roma La Sapienza, Dept Med Surg Sci & Biotechnol, Vasc Biol Atherothrombosis & Mass Spectrometry La, Corso Repubbl 79, I-04100 Latina, Italy.
EM luigi.iuliano@uniroma1.it
RI Ducheix, Simon/AEE-4943-2022; Guillou, Herve/AAG-2826-2020; Iuliano,
   Luigi/A-5266-2008
OI Ducheix, Simon/0000-0001-6676-4263; Iuliano, Luigi/0000-0002-0027-9326;
   Guillou, Herve/0000-0002-5363-9081
FU ANR - France Crisalis; Sapienza University of Rome - Italy [C26A13YNTT]
FX The laboratory involved in this work are members of the European Network
   for Oxysterol Research (ENOR) and wish to thank the ENOR members for
   their input and for fruitful discussions. HG is supported by a grant
   from the ANR - France Crisalis (2012-2015). This work was supported in
   part by a grant from Sapienza University of Rome - Italy (Grant Ateneo
   2013 # C26A13YNTT, to LI).
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NR 38
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U1 0
U2 28
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0039-128X
EI 1878-5867
J9 STEROIDS
JI Steroids
PD JUL
PY 2015
VL 99
SI SI
BP 287
EP 292
DI 10.1016/j.steroids.2015.03.019
PN B
PG 6
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA CL5FK
UT WOS:000356985000024
PM 25896943
OA Green Published
DA 2025-06-11
ER

PT J
AU Saroj, M
   Prakash, S
   Vikram, NK
   Saraya, A
   Priyatma
   Ganie, MA
   Arulselvi, S
   Pandey, S
AF Saroj, Manish
   Prakash, Shyam
   Vikram, Naval K.
   Saraya, Anoop
   Priyatma
   Ganie, Mohd Ashraf
   Arulselvi, Subramanian
   Pandey, Shivam
TI Hyperactive behaviour of growth differentiation factor-15 (GDF-15) in
   conjunction with iron trafficking transporters and suppression of Nrf-2
   gene in diabetes and metabolic syndrome
SO MOLECULAR AND CELLULAR BIOCHEMISTRY
LA English
DT Article
DE Iron trafficking genes; Diabetes; Metabolic aberration; GDF-15mRNA;
   Adipokine
ID INSULIN-RESISTANCE; OXIDATIVE STRESS; DYSLIPIDEMIA; FERRITIN; ASSAY
AB Multiple parallel factors are frequently interrogated with various toxic radicals which are abundantly generated in the liver, heart, and pancreas in stress conditions. They are actively involved in the development of diabetes and metabolic aberrations. However, whether over-activation of GDF-15mRNA and influxes of iron-by-iron trafficking genes are directly suppressing the Nrf-2 gene in patients with diabetes and metabolic aberrations in context with undiagnosed individuals with diabetes and metabolic aberrations? Therefore, we have investigated inter and intra- related Zip8/14 mRNA, GDF-15mRNA, and Nrf-2 mRNA expressions in diabetes and metabolic syndrome as it is expected to be up to 134 million by 2045 in India. We recruited 120 subjects from the Department of Medicine, Endocrinology and Metabolic Clinic, All India Institute of Medical Sciences, New Delhi, India. Various investigations related to anthropometry, nutritional, hematological, biochemical, cytokine, and oxidative stress were measured in diabetes, metabolic syndrome, diabetes with metabolic aberration, and healthy controls. Relative expression of GDF-15, ZIP8, ZIP14, Nrf-2, and housekeeping genes was done in all subjects. Stress-responsive cytokines are highly expressed in patients with metabolic aberration with respect to body weight, IR, waist circumference, and fat mass. IL-1 & beta;, TNF-& alpha;, and IL-6 levels were significantly higher in metabolic syndrome, whereas Adiponectin levels were profoundly lower side. MDA levels were significantly raised in diabetes with metabolic syndrome while SOD activities were lowered (p = 0.001). GDF-15 mRNA expression was 1.79-fold upregulated in group III as compared with Group I while 2-threefold down-regulation of Nrf-2 expression was observed in diabetes with metabolic aberration groups. Zip 8 mRNA expressions were downregulated (p = 0.014), and Zip 14 mRNA expressions were upregulated (p = 0.06) in diabetes and metabolic aberrations. The association of GDF-15 and Nrf-2 mRNA expression was found contradictory and highly interlinked with ROS. Zip 8/14mRNA expressions were also dysregulated in diabetes and metabolic-associated complications.
C1 [Saroj, Manish; Prakash, Shyam; Priyatma] AIIMS, Dept Lab Med, New Delhi, India.
   [Vikram, Naval K.] AIIMS, Dept Med, New Delhi, India.
   [Saraya, Anoop] AIIMS, Dept Gastroenterol, New Delhi, India.
   [Pandey, Shivam] AIIMS, Dept Biostat, New Delhi, India.
   [Ganie, Mohd Ashraf] SKIMS, Dept Endocrinol, Srinagar, India.
   [Arulselvi, Subramanian] AIIMS, JPN Apex Trauma Ctr, Dept Lab Med, New Delhi, India.
   [Prakash, Shyam] All India Inst Med Sci, Dept Lab Med, Room 11,2nd Floor, New Delhi, India.
C3 All India Institute of Medical Sciences (AIIMS) New Delhi; All India
   Institute of Medical Sciences (AIIMS) New Delhi; All India Institute of
   Medical Sciences (AIIMS) New Delhi; All India Institute of Medical
   Sciences (AIIMS) New Delhi; Sher-i-Kashmir Institute of Medical
   Sciences; All India Institute of Medical Sciences (AIIMS) New Delhi; Jai
   Prakash Narayan Apex Trauma Center; All India Institute of Medical
   Sciences (AIIMS) New Delhi
RP Prakash, S (corresponding author), AIIMS, Dept Lab Med, New Delhi, India.; Prakash, S (corresponding author), All India Inst Med Sci, Dept Lab Med, Room 11,2nd Floor, New Delhi, India.
EM prakashaiims@gmail.com
RI Prakash, Choudhary/Y-2314-2019; Ganie, Mohd/AAL-2416-2020; subramaniam,
   arulselvi/AAG-1670-2020
OI , Priyatma/0000-0002-0090-3686; subramaniam,
   arulselvi/0000-0001-7797-6683
FU ICMR, New Delhi
FX ICMR, New Delhi, is the funding agency to carried out research work and
   data collection done in regards to this study
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NR 34
TC 1
Z9 1
U1 1
U2 6
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0300-8177
EI 1573-4919
J9 MOL CELL BIOCHEM
JI Mol. Cell. Biochem.
PD MAY
PY 2024
VL 479
IS 5
BP 1109
EP 1120
DI 10.1007/s11010-023-04782-4
EA JUN 2023
PG 12
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA RV0S5
UT WOS:001011785900001
PM 37338675
DA 2025-06-11
ER

PT J
AU Happell, B
   Platania-Phung, C
   Furness, T
   Scholz, B
   Niyonsenga, T
   Watkins, A
   Curtis, J
   Wang, ZJ
   Khanijou, S
   Stanton, R
AF Happell, Brenda
   Platania-Phung, Chris
   Furness, Trentham
   Scholz, Brett
   Niyonsenga, Theo
   Watkins, Andrew
   Curtis, Jackie
   Wang, Zijian
   Khanijou, Supriya
   Stanton, Robert
TI Physical Health and Health Behaviours of Australians with Psychosis
SO COMMUNITY MENTAL HEALTH JOURNAL
LA English
DT Article
DE Nurse-led; Physical health; Cardiovascular diseases; Metabolic syndrome;
   Mortality; Equally well
ID QUALITY-OF-LIFE; MENTAL-ILLNESS; RISK-FACTORS; METABOLIC RISK; PEOPLE;
   SCHIZOPHRENIA; CARE; INTERVENTIONS; DISORDERS; EXERCISE
AB People living with psychosis live up to 20 years less compared to the general population. Cardiometabolic ill-health and barriers to health-related behaviour are significant contributors. This is a cross-sectional descriptive study of cardiometabolic health and health behaviours of consumers attending a public community mental health service in an Australian city. One hundred and fourteen consumers currently living with psychosis participated. Standard measures of cardiometabolic health, quality of life and, health-related behaviours were utilised. Data were analysed using descriptive statistics. The cohort reported higher fruit intake and physical activity, and lower excess alcohol use compared to previous studies. Health-related behaviours including smoking and vegetable intake were poorer than previously reported. Participants had low levels of cardiometabolic health (e.g. abnormal lipids). Physical and mental quality of life was also lower than for general populations. Improved efforts to address physical health for people with mental health conditions are urgently needed.
C1 [Happell, Brenda; Platania-Phung, Chris] Southern Cross Univ, Fac Hlth, Lismore, Australia.
   [Happell, Brenda] Univ Newcastle, Sch Nursing & Midwifery, Callaghan, Australia.
   [Happell, Brenda] Equally Well, Orange, Australia.
   [Furness, Trentham] Forensicare, Melbourne, Australia.
   [Scholz, Brett; Wang, Zijian] Australian Natl Univ, Sch Med & Psychol, Canberra, Australia.
   [Niyonsenga, Theo] Univ Canberra, Hlth Res Inst, Canberra, Australia.
   [Watkins, Andrew; Curtis, Jackie] Mindgardens Neurosci Network, Sydney, Australia.
   [Curtis, Jackie] Univ New South Wales, Discipline Psychiat & Mental Hlth, Sydney, Australia.
   [Khanijou, Supriya] Deakin Univ, Geelong, Australia.
   [Stanton, Robert] Appleton Inst, Sch Hlth Med & Appl Sci CQUnivers, Cluster Resilience & Wellbeing, Rockhampton, Australia.
C3 Southern Cross University; University of Newcastle; Australian National
   University; University of Canberra; Mindgardens Neuroscience Network;
   University of New South Wales Sydney; Deakin University
RP Happell, B (corresponding author), Southern Cross Univ, Fac Hlth, Lismore, Australia.; Happell, B (corresponding author), Univ Newcastle, Sch Nursing & Midwifery, Callaghan, Australia.; Happell, B (corresponding author), Equally Well, Orange, Australia.
EM Brenda.happell@scu.edu.au
RI Scholz, Brett/AAB-5196-2019; Furness, Trentham/N-8563-2016; Happell,
   Brenda/HSI-0570-2023; Niyonsenga, Theophile/C-3759-2014
OI Niyonsenga, Theophile/0000-0002-6723-0316; Stanton,
   Robert/0000-0002-6684-5087
FU Southern Cross University; National Health and Medical Research Council
FX This study was supported by a National Health and Medical Research
   Council project grant.
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NR 97
TC 0
Z9 0
U1 0
U2 0
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0010-3853
EI 1573-2789
J9 COMMUNITY MENT HLT J
JI Community Ment. Health J.
PD MAY
PY 2025
VL 61
IS 4
BP 797
EP 808
DI 10.1007/s10597-024-01417-w
EA FEB 2025
PG 12
WC Health Policy & Services; Public, Environmental & Occupational Health;
   Psychiatry
WE Social Science Citation Index (SSCI)
SC Health Care Sciences & Services; Public, Environmental & Occupational
   Health; Psychiatry
GA 0YD2T
UT WOS:001426398000001
PM 39976847
OA hybrid
DA 2025-06-11
ER

PT J
AU Cardet, JC
   Bulkhi, AA
   Lockey, RF
AF Cardet, Juan Carlos
   Bulkhi, Adeeb A.
   Lockey, Richard F.
TI Nonrespiratory Comorbidities in Asthma
SO JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
LA English
DT Review
DE Insulin resistance; Atherosclerotic cardiovascular disease; Adrenal
   disease; Thyroid disease; Pregnancy; Osteoporosis; Adverse effects from
   medications; Mental health disorders; Airway hyperresponsiveness; Asthma
ID GLUCOCORTICOID-INDUCED OSTEOPOROSIS; CONVERTING ENZYME-INHIBITORS;
   ALLERGIC-ASTHMA; BRONCHIAL-ASTHMA; BETA-BLOCKER; ANTITHYROID PEROXIDASE;
   ADRENAL INSUFFICIENCY; INSULIN-RESISTANCE; PULMONARY-FUNCTION; METABOLIC
   SYNDROME
AB Asthma is a chronic heterogeneous airway disease. Common comorbid conditions are often disproportionately present in severe asthma. Optimal care of patients with asthma requires the recognition and treatment of these comorbid conditions. This review outlines the pathophysiological mechanisms between nonrespiratory comorbid conditions and asthma and their effect on asthma outcomes. They include: type 2 diabetes mellitus, hypertension, atherosclerotic cardiovascular disease, adrenal and thyroid gland diseases, pregnancy, osteoporosis, adverse effects from medications, and mental health disorders. Studies indicate how poor glycemic control of type 2 diabetes mellitus is associated with not only greater health care utilization but poorer asthma outcomes. Also, a large health care claims database indicates that a substantial proportion of pregnant women have uncontrolled asthma and are prescribed suboptimal controller therapy. Additional data about these nonrespiratory comorbidities and medications known to benefit both nonrespiratory comorbidities and asthma are necessary. (C) 2021 American Academy of Allergy, Asthma & Immunology
C1 [Cardet, Juan Carlos; Bulkhi, Adeeb A.; Lockey, Richard F.] Univ S Florida, Morsani Coll Med, Dept Internal Med, Div Allergy & Immunol, Tampa, FL 33620 USA.
   [Bulkhi, Adeeb A.] Umm Al Qura Univ, Coll Med, Dept Internal Med, Mecca, Saudi Arabia.
   [Lockey, Richard F.] James A Haley Vet Hosp, Dept Internal Med, Tampa, FL 33612 USA.
C3 State University System of Florida; University of South Florida; Umm
   Al-Qura University; US Department of Veterans Affairs; Veterans Health
   Administration (VHA); James A. Haley Veterans Hospital
RP Lockey, RF (corresponding author), Univ S Florida, Morsani Coll Med, Dept Internal Med, Div Allergy & Immunol, Tampa, FL 33620 USA.
EM rlockey@usf.edu
RI Bulkhi, Adeeb/AAD-8924-2019
OI Bulkhi, Adeeb/0000-0001-5857-7097
FU National Institute of Allergy and Infectious Diseases (NIAID)
   [K23AI125785]; American Lung Association/American Academy of Allergy,
   Asthma, and Immunology (ALA/AAAAI) [AI-835475]; National Institute of
   Allergy and Infectious Diseases [K23AI125785] Funding Source: NIH
   RePORTER
FX This work was conducted with the support of grant K23AI125785 from the
   National Institute of Allergy and Infectious Diseases (NIAID) and the
   Allergic Respiratory Diseases Research Award AI-835475 from American
   Lung Association/American Academy of Allergy, Asthma, and Immunology
   (ALA/AAAAI) to J. C. Cardet; by generous contributions by the
   Culverhouse family fund in Tampa to J. C. Cardet and R. F. Lockey, and
   by the James A. Haley Veterans' Affairs Hospital to R. F. Lockey.
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NR 140
TC 22
Z9 23
U1 0
U2 8
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2213-2198
EI 2213-2201
J9 J ALLER CL IMM-PRACT
JI J. Allergy Clin. Immunol.-Pract.
PD NOV
PY 2021
VL 9
IS 11
BP 3887
EP 3897
DI 10.1016/j.jaip.2021.08.027
EA NOV 2021
PG 11
WC Allergy; Immunology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Allergy; Immunology
GA YU2CZ
UT WOS:000751856700007
PM 34492402
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Grosso, G
   Marventano, S
   D'Urso, M
   Mistretta, A
   Galvano, F
AF Grosso, Giuseppe
   Marventano, Stefano
   D'Urso, Maurizio
   Mistretta, Antonio
   Galvano, Fabio
TI The Mediterranean healthy eating, ageing, and lifestyle (MEAL) study:
   rationale and study design
SO INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION
LA English
DT Article
DE Mediterranean diet; sleep; sun exposure; depression; quality of life;
   stress
ID FOOD FREQUENCY QUESTIONNAIRE; CARDIOVASCULAR RISK-FACTORS; ALL-CAUSE
   MORTALITY; VITAMIN-D STATUS; QUALITY-OF-LIFE; SOCIAL NETWORKS; METABOLIC
   SYNDROME; FISH CONSUMPTION; SLEEP DURATION; NUT CONSUMPTION
AB There is accumulating evidence suggesting that Mediterranean lifestyles, including nutrition and sleeping patterns as well as social integration, may play a role in reducing age-related diseases. However, the literature is mostly deficient of evidence provided by Italian Mediterranean islands that more closely adhered to the originally described lifestyles. In this paper, we described the rationale and the study design of the Mediterranean healthy Eating, Ageing, and Lifestyle (MEAL) study, a prospective population-based cohort established in Sicily, southern Italy. The main exposures investigated are classical determinants of health, including demographic, nutritional habits, smoking and physical activity status, as well as eating-related behaviors, sleeping habits, sun exposure, social resources, and perceived stress. Anthropometric measurements will be collected. The main outcomes included depression, quality of life, and, after the follow-up period, also cardiovascular disease and cancer. The MEAL study may provide important data to increase our knowledge regarding the prevalence, incidence, and risk factors of age-related disorders in the Mediterranean region.
C1 [Grosso, Giuseppe] Azienda Osped Univ Policlin Vittorio Emanuele, Integrated Canc Registry Catania Messina Siracusa, Catania, Italy.
   [Marventano, Stefano; Mistretta, Antonio] Univ Catania, Dept Med Surg Sci & Adv Technol GF Ingrassia, Sect Hyg & Publ Hlth, Catania, Italy.
   [D'Urso, Maurizio] Prov Hlth Author Catania, Catania, Italy.
   [Galvano, Fabio] Univ Catania, Dept Biomed & Biotechnol Sci, Catania, Italy.
C3 University of Catania; University Catania Hospital; Azienda Ospedaliera
   Universitaria Policlinico Vittorio Emanuele Presidio Ferraotto;
   University of Catania; University of Catania
RP Grosso, G (corresponding author), Integrated Canc Registry Catania Messina Siracusa, Via S Sofia 85, I-95123 Catania, Italy.
EM giuseppe.grosso@studium.unict.it
RI Mistretta, Antonio/J-5770-2012; Galvano, Fabio/JSL-7451-2023; Galvano,
   Fabio/F-8122-2010; Grosso, Giuseppe/K-6730-2016
OI Galvano, Fabio/0000-0003-0644-0755; Grosso, Giuseppe/0000-0003-3930-5285
FU University of Catania
FX University of Catania.
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NR 84
TC 51
Z9 52
U1 0
U2 33
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0963-7486
EI 1465-3478
J9 INT J FOOD SCI NUTR
JI Int. J. Food Sci. Nutr.
PY 2017
VL 68
IS 5
BP 577
EP 586
DI 10.1080/09637486.2016.1262335
PG 10
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Food Science & Technology; Nutrition & Dietetics
GA EV9CH
UT WOS:000402081600008
PM 27919168
DA 2025-06-11
ER

PT J
AU Rashidi, BH
   Hosseinzadeh, FM
   Alipoor, E
   Asghari, S
   Yekaninejad, MS
   Hosseinzadeh-Attar, MJ
AF Rashidi, Batool Hossein
   Hosseinzadeh, Fatemeh Mohammad
   Alipoor, Elham
   Asghari, Somayyeh
   Yekaninejad, Mir Saeed
   Hosseinzadeh-Attar, Mohammad Javad
TI Effects of Selenium Supplementation on Asymmetric Dimethylarginine and
   Cardiometabolic Risk Factors in Patients with Polycystic Ovary Syndrome
SO BIOLOGICAL TRACE ELEMENT RESEARCH
LA English
DT Article
DE Asymmetric dimethylarginine; Cardiometabolic risk factors; Polycystic
   ovary syndrome; Selenium
ID CARDIOVASCULAR-DISEASE RISK; ENDOTHELIAL DYSFUNCTION; OXIDATIVE STRESS;
   NITRIC-OXIDE; PLASMA-LEVELS; DOUBLE-BLIND; L-ARGININE; WOMEN; ADMA;
   OBESITY
AB Polycystic ovary syndrome (PCOS) is characterized by various reproductive and cardiometabolic disorders. Asymmetric dimethylarginine (ADMA) is associated with cardiovascular, metabolic, and hormonal status. Selenium, a micronutrient with antioxidant properties, could affect multiple physiological pathways. This study aimed to investigate the effect of selenium supplementation on ADMA, cardiometabolic risk factors, and hormonal status in women with PCOS. In this randomized, double-blind, placebo-controlled clinical trial, 66 women with PCOS, aged 18-45 years, were randomly assigned to receive either 200 mu g/day selenium or placebo, for 12 weeks. Circulating concentrations of ADMA, testosterone, sex hormone-binding globulin (SHBG), lipid profiles, and glycemic parameters were assessed at baseline and following supplementation. ADMA concentration decreased significantly compared to baseline values (85.14 +/- 75 to 56.4 +/- 38.64 ng/l, p = 0.02) in the selenium group. This change was marginally significant compared with the placebo group (28.74 +/- 68.63 vs. - 1.77 +/- 52.88 ng/l, p = 0.056). Serum testosterone levels declined significantly in the intervention compared to the placebo group (0.01 +/- 0.17 vs. - 0.08 +/- 0.18 ng/ml, p = 0.038). Pre- to post-Apo-B100/Apo-A1 ratio declined considerably in the intervention group (0.72 +/- 0.16 to 0.65 +/- 0.16, p = 0.003). No further differences were observed in SHBG, lipid profiles, Apo-A1, Apo-B100, Apo-B100/Apo-A1 ratio, and glycemic control between the two groups at the end of the study. Selenium supplementation for 12 weeks had beneficial effects on reduction of circulating ADMA and total testosterone levels in women with PCOS. No significant improvements were seen in other cardiometabolic risk factors. The effects of selenium supplementation on hormonal, reproductive, and cardiometabolic disorders, considering the potential mediating role of ADMA, should be further investigated.
C1 [Rashidi, Batool Hossein] Univ Tehran Med Sci, Vali E Asr Reprod Hlth Res Ctr, Tehran, Iran.
   [Hosseinzadeh, Fatemeh Mohammad; Asghari, Somayyeh; Hosseinzadeh-Attar, Mohammad Javad] Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Clin Nutr, 44 Hojjatdoust St,Naderi St,Keshavarz Blvd, Tehran 141556117, Iran.
   [Alipoor, Elham] Iran Univ Med Sci, Sch Publ Hlth, Dept Nutr, Tehran, Iran.
   [Yekaninejad, Mir Saeed] Univ Tehran Med Sci, Sch Publ Hlth, Dept Epidemiol & Biostat, Tehran, Iran.
   [Hosseinzadeh-Attar, Mohammad Javad] Univ Tehran Med Sci, Tehran Heart Ctr, CPPRC, Tehran, Iran.
C3 Tehran University of Medical Sciences; Tehran University of Medical
   Sciences; Iran University of Medical Sciences; Tehran University of
   Medical Sciences; Tehran University of Medical Sciences
RP Hosseinzadeh-Attar, MJ (corresponding author), Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Clin Nutr, 44 Hojjatdoust St,Naderi St,Keshavarz Blvd, Tehran 141556117, Iran.; Hosseinzadeh-Attar, MJ (corresponding author), Univ Tehran Med Sci, Tehran Heart Ctr, CPPRC, Tehran, Iran.
EM hosseinzadeh.md.phd@gmail.com
RI Yekaninejad, Mir/L-6752-2016; Alipoor, Elham/ABB-5878-2021;
   Hosseinzadeh-Attar, Mohammad Javad/E-9358-2018
OI Alipoor, Elham/0000-0002-9463-6354; Hosseinzadeh-Attar, Mohammad
   Javad/0000-0002-5787-4089
FU Tehran University of Medical Sciences and Health Services grant [26211]
FX The present study was supported by Tehran University of Medical Sciences
   and Health Services grant 26211.
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NR 49
TC 24
Z9 24
U1 1
U2 8
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0163-4984
EI 1559-0720
J9 BIOL TRACE ELEM RES
JI Biol. Trace Elem. Res.
PD AUG
PY 2020
VL 196
IS 2
BP 430
EP 437
DI 10.1007/s12011-019-01954-6
EA OCT 2019
PG 8
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA MF2FT
UT WOS:000493356500001
PM 31667685
DA 2025-06-11
ER

PT J
AU Esposito, M
   Gallai, B
   Roccella, M
   Marotta, R
   Lavano, F
   Lavano, SM
   Mazzotta, G
   Bove, D
   Sorrentino, M
   Precenzano, F
   Carotenuto, M
AF Esposito, Maria
   Gallai, Beatrice
   Roccella, Michele
   Marotta, Rosa
   Lavano, Francesco
   Lavano, Serena Marianna
   Mazzotta, Giovanni
   Bove, Domenico
   Sorrentino, Michele
   Precenzano, Francesco
   Carotenuto, Marco
TI Anxiety and depression levels in prepubertal obese children: a
   case-control study
SO NEUROPSYCHIATRIC DISEASE AND TREATMENT
LA English
DT Article
DE childhood obesity; internalizing problems; SAFA; CDI
ID BODY-MASS INDEX; PRIMARY NOCTURNAL ENURESIS; GENE VARIABLE NUMBER;
   INS-VNTR GENOTYPE; PHYSICAL-ACTIVITY; PSYCHIATRIC-DISORDERS; METABOLIC
   SYNDROME; SLEEP-APNEA; WAIST CIRCUMFERENCE; OVERWEIGHT CHILDREN
AB Introduction: Childhood obesity has become a worldwide epidemic in Western and in developing countries and has been accompanied by many serious and severe comorbidities, such as diabetes, hypertension, sleep apnea syndrome, depression, dyslipidemia, impaired glucose homeostasis, steatohepatitis, and intracranial hypertension, as well as medical concerns unique to youth, such as accelerated pubertal and skeletal development and orthopedic disorders. To date, no specific studies about the psychological assessment in pediatric obesity are present. Therefore, the aim of this study was to evaluate the putative relationship between psychological troubles and obesity in a sample of school-aged children.
   Materials and methods: The study population consists of 148 obese subjects (body mass index [BMI] >95th percentile) (69 males, mean age 8.9 +/- 1.23 years) consecutively referred from clinical pediatricians to the Child and Adolescent Neuropsychiatry department at the Second University of Naples. In all subjects, weight, height, and BMI z-score were evaluated. In order to assess the anxiety levels and the presence of depressive symptoms, the Children Depression Inventory (CDI) and the Italian Self-Administered Psychiatric Scales for Children and Adolescents (SAFA) were administered. The control group consisted of 273 healthy children (129 males and 144 females) (mean age 9.1 +/- 1.8 years), enrolled in schools within the Campania region of Italy.
   Results: No significant differences between the two study groups were found for age (8.9 +/- 1.23 years in the obese sample and 9.1 +/- 1.8 years in the control group) (P=0.228) or sex (ratio male/female: 69/79 in the obese group versus 129/144 in the control group) (P=0.983). Obviously, significant difference was found for the BMI z-score (2.46 +/- 0.31 in the obese group vs 0.73 +/- 0.51 in the control group) (P<0.001). The obese subjects showed significant higher level of depressive symptoms (CDI total score) (16.82 +/- 7.73 vs 8.2 +/- 2.9) (P<0.001) and anxiety (SAFA - Anxiety [SAFA-A]) scale score (58.71 +/- 11.84 vs 27.75 +/- 11.5) (P<0.001) compared with the control group. Moreover, the Pearson's correlation analysis showed a significantly positive relationship between the BMI z-score and both the CDI (r=0.677; P<0.001) and SAFA-A scores (r=0.591; P<0.001).
   Conclusion: Our findings highlighted the importance of assessing the presence of internalizing problems, such as anxiety and depression, in the common management of childhood obesity.
C1 [Esposito, Maria; Sorrentino, Michele; Precenzano, Francesco; Carotenuto, Marco] Univ Naples 2, Dept Mental Hlth Phys & Prevent Med, Clin Child & Adolescent Neuropsychiat, Naples, Italy.
   [Gallai, Beatrice] Univ Perugia, Unit Child & Adolescent Neuropsychiat, I-06100 Perugia, Italy.
   [Roccella, Michele] Univ Palermo, Dept Psychol, Palermo, Italy.
   [Marotta, Rosa; Lavano, Francesco; Lavano, Serena Marianna] Magna Graecia Univ Catanzaro, Dept Psychiat, Catanzaro, Italy.
   [Mazzotta, Giovanni] AUSL Umbria 2, Unit Child & Adolescent Neuropsychiat, Terni, Italy.
   [Bove, Domenico] Ctr Diag & Cura Disturbi, Apprendimento Comportamento Assoc Ric sci Fusis, Alvignano, Italy.
C3 Universita della Campania Vanvitelli; University of Perugia; University
   of Palermo; Magna Graecia University of Catanzaro
RP Gallai, B (corresponding author), Univ Perugia, Unit Child & Adolescent Neuropsychiat, Via Enrico dal Pozzo, I-06100 Perugia, Italy.
EM beagallai@gmail.com
RI Roccella, Michele/IQT-9631-2023; Carotenuto, Marco/E-2575-2012; Marotta,
   Rosa/AAG-1453-2020; ESPOSITO, Maria/K-7781-2016
OI Esposito, Maria/0009-0002-7388-2721; ESPOSITO,
   Maria/0000-0001-7095-7957; Precenzano, Francesco/0000-0002-3812-1786;
   Marotta, Rosa/0000-0003-0515-5952; ROCCELLA,
   Michele/0000-0002-7371-0228; CAROTENUTO, Marco/0000-0002-8136-7597
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NR 108
TC 105
Z9 109
U1 0
U2 25
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
EI 1178-2021
J9 NEUROPSYCH DIS TREAT
JI Neuropsychiatr. Dis. Treat.
PY 2014
VL 10
BP 1897
EP 1902
DI 10.2147/NDT.S69795
PG 6
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA AR2IL
UT WOS:000343407400001
PM 25336955
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Makkar, H
   Reynolds, MA
   Wadhawan, A
   Dagdag, A
   Merchant, AT
   Postolache, TT
AF Makkar, Hina
   Reynolds, Mark A.
   Wadhawan, Abhishek
   Dagdag, Aline
   Merchant, Anwar T.
   Postolache, Teodor T.
TI Periodontal, metabolic, and cardiovascular disease: Exploring the role
   of inflammation and mental health
SO PTERIDINES
LA English
DT Article
DE Periodontitis; metabolic syndrome; cardiovascular disease; mental
   illness; inflammation
ID C-REACTIVE PROTEIN; TUMOR-NECROSIS-FACTOR; GINGIVAL CREVICULAR FLUID;
   CORONARY-HEART-DISEASE; PERIPHERAL ARTERIAL-DISEASE; GLYCATION
   END-PRODUCTS; ACUTE MYOCARDIAL-INFARCTION; DEPENDENT DIABETES-MELLITUS;
   GENOME-WIDE ASSOCIATION; ACUTE-PHASE REACTANTS
AB Previous evidence connects periodontal disease, a modifiable condition affecting a majority of Americans, with metabolic and cardiovascular morbidity and mortality. This review focuses on the likely mediation of these associations by immune activation and their potential interactions with mental illness. Future longitudinal, and ideally interventional studies, should focus on reciprocal interactions and cascading effects, as well as points for effective preventative and therapeutic interventions across diagnostic domains to reduce morbidity, mortality and improve quality of life.
C1 [Makkar, Hina; Wadhawan, Abhishek; Dagdag, Aline; Postolache, Teodor T.] Univ Maryland, Sch Med, Dept Psychiat, Mood & Anxiety Program, Baltimore, MD 21201 USA.
   [Postolache, Teodor T.] Mil & Vet Microbiome Consortium Res & Educ MVM Co, Rocky Mt Mental Illness Res Educ & Clin Ctr MIREC, Vet Integrated Serv Network VISN 19, Denver, CO 80220 USA.
   [Postolache, Teodor T.] VA Capitol Hlth Care Network, MIRECC, Vet Integrated Serv Network VISN 5, Baltimore, MD 21201 USA.
   [Reynolds, Mark A.] Univ Maryland, Sch Dent, Dept Adv Oral Sci & Therapeut, Baltimore, MD 21201 USA.
   [Wadhawan, Abhishek] St Elizabeth Hosp, Psychiat Residency Training Program, Washington, DC 20032 USA.
   [Merchant, Anwar T.] Univ South Carolina, Arnold Sch Publ Hlth, Dept Epidemiol & Biostat, Columbia, SC 29208 USA.
C3 University System of Maryland; University of Maryland Baltimore;
   University System of Maryland; University of Maryland Baltimore;
   University of South Carolina System; University of South Carolina
   Columbia
RP Postolache, TT (corresponding author), Univ Maryland, Sch Med, Dept Psychiat, Mood & Anxiety Program, Baltimore, MD 21201 USA.; Postolache, TT (corresponding author), Mil & Vet Microbiome Consortium Res & Educ MVM Co, Rocky Mt Mental Illness Res Educ & Clin Ctr MIREC, Vet Integrated Serv Network VISN 19, Denver, CO 80220 USA.; Postolache, TT (corresponding author), VA Capitol Hlth Care Network, MIRECC, Vet Integrated Serv Network VISN 5, Baltimore, MD 21201 USA.
EM tpostola@som.umaryland.edu
RI Merchant, Anwar/B-5233-2009; Reynolds, Mark/AAO-9707-2021; Wadhawan,
   Abhishek/K-5798-2019; Stefanadis, Christodoulos/ABH-2232-2020
OI Postolache, Teodor/0000-0001-6056-4244; Stefanadis,
   Christodoulos/0000-0001-5974-6454
FU Mid-Atlantic Nutrition Obesity Research Center Pilot NORC grant [P30
   DK072488]; Rocky Mountain MIRECC, Denver Colorado; Military and Veteran
   Microbiome Consortium for Research and Education (MVM-CoRE), Denver, CO.
FX This work was supported by the Mid-Atlantic Nutrition Obesity Research
   Center Pilot NORC grant (Postolache, PI), a subaward of the parent grant
   P30 DK072488 (Mitchell, PI). Additional support for the writing of this
   manuscript was provided by the Rocky Mountain MIRECC, Denver Colorado
   and Military and Veteran Microbiome Consortium for Research and
   Education (MVM-CoRE), Denver, CO. The authors thank Alexandra Dagdag for
   her help in proofreading this manuscript. We thank the staff of the
   Amish Research Clinic of the University of Maryland for their overall
   support and the trainees of the Mood and Anxiety Program for their help
   with references, mailings and data management. The views, opinions and
   findings contained in this article belong to the authors and should not
   be construed as an official position of the NIH, or the US Department of
   Veterans Affairs.
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NR 633
TC 31
Z9 35
U1 0
U2 9
PU DE GRUYTER POLAND SP Z O O
PI WARSAW
PA BOGUMILA ZUGA 32A STR, 01-811 WARSAW, MAZOVIA, POLAND
SN 0933-4807
EI 2195-4720
J9 PTERIDINES
JI Pteridines
PD FEB
PY 2018
VL 29
IS 1
BP 124
EP 163
DI 10.1515/pteridines-2018-0013
PG 40
WC Biochemistry & Molecular Biology; Biophysics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Biochemistry & Molecular Biology; Biophysics
GA HM0FF
UT WOS:000459121400002
PM 30705520
OA Green Accepted, gold
DA 2025-06-11
ER

PT J
AU Rygula, I
   Pikiewicz, W
   Kaminiów, K
AF Rygula, Izabella
   Pikiewicz, Wojciech
   Kaminiow, Konrad
TI Impact of Diet and Nutrition in Patients with Acne Vulgaris
SO NUTRIENTS
LA English
DT Review
DE acne; diet; nutrition; skin; dermatology disease
ID INSULIN-RESISTANCE; METABOLIC SYNDROME; GLYCEMIC LOAD; FATTY-ACIDS;
   CONSUMPTION; EPIDEMIOLOGY; PROTEIN; ADOLESCENTS; ADULTS; COCOA
AB Acne vulgaris is a widespread a chronic inflammatory dermatosis that affects millions of people around the world, which has a significant influence on patients' standard of living. The progression of this dermatosis results in the appearance of inflammatory and non-inflammatory changes, and, in severe cases, disfiguring scars and hyperpigmentation. The aetiopathogenesis of acne is complex. It involves a complex interaction of many different factors, both endo- and exogenous in their effect on the hair and sebaceous unit. Genetic predisposition, hormones, the skin and gut microbiome, psychological stress, air pollutants, aggressive facial products, and certain medications are cited as factors influencing acne formation. The link between nutrition and acne is extensively debated for many years and is still relatively controversial. Diet is commonly recognised to have a direct relationship with certain biochemical markers and the transcription of genes related to sebaceous gland function, and the proliferation of bacteria and inflammation that encourage the progression of the disease. In this review, the authors take a closer look at the existing scientific reports on the involvement of nutrition in the development of acne vulgaris.
C1 [Rygula, Izabella] Med Univ Silesia, Fac Med Sci Katowice, PL-40752 Katowice, Poland.
   [Pikiewicz, Wojciech; Kaminiow, Konrad] WSB Univ, Fac Med, Coll Med, PL-41300 Dabrowa Gornicza, Poland.
C3 Medical University of Silesia; WSB University
RP Kaminiów, K (corresponding author), WSB Univ, Fac Med, Coll Med, PL-41300 Dabrowa Gornicza, Poland.
EM izabella.ryg@gmail.com; wojciech.pikiewicz@wsb.edu.pl;
   konrad.kaminiow@wsb.edu.pl
OI Rygula, Izabella/0000-0002-1759-2140; Kaminiow,
   Konrad/0000-0002-7481-2621
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NR 101
TC 10
Z9 10
U1 10
U2 16
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD MAY
PY 2024
VL 16
IS 10
AR 1476
DI 10.3390/nu16101476
PG 17
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA RZ7K8
UT WOS:001231543000001
PM 38794714
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU De Simoni, E
   Rizzetto, G
   Molinelli, E
   Capodaglio, I
   Offidani, A
   Simonetti, O
AF De Simoni, Edoardo
   Rizzetto, Giulio
   Molinelli, Elisa
   Capodaglio, Irene
   Offidani, Annamaria
   Simonetti, Oriana
TI The Role of Diet in Children with Psoriasis: Emerging Evidence and
   Current Issues
SO NUTRIENTS
LA English
DT Review
DE psoriasis; pediatric population; Mediterranean diet; gluten-free diet;
   low-calorie diet
ID CELIAC-DISEASE; METABOLIC SYNDROME; GUT MICROBIOTA; FATTY-ACIDS;
   INFLAMMATION; ASSOCIATION; ANTIBODIES; EXCESS; LIPIDS
AB Psoriasis is an immune-mediated inflammatory systemic disease with skin tropism and chronic relapsing course; it is associated with an increased cardiovascular risk and with many metabolic comorbidities, emerging during childhood in 22-33% of cases. Diet influences the presentation and the clinical course of inflammatory diseases, including psoriasis; in particular, it was shown that a Mediterranean, gluten-free, or low-calorie diet may positively affect disease control in adult patients with psoriasis and adequate pharmacological therapy. These three dietary regimens may play a role also in children with psoriasis. It has been demonstrated that pediatric psoriasis is associated with psychological stress, celiac disease, and obesity, which may be positively influenced by these dietary regimens, respectively. Therefore, the expertise of multiple health figures (gastroenterologists, nutritionists, pediatricians, dermatologists) is required to plan a tailor-made dietary strategy, ensuring good growth, through an adequate intake of essential micro- and macronutrients and, at the same time, impacting the pro-inflammatory biochemical profile and on the associated cardiovascular risk of psoriasis disease.
C1 [De Simoni, Edoardo; Rizzetto, Giulio; Molinelli, Elisa; Offidani, Annamaria; Simonetti, Oriana] Polytech Univ Marche, Dept Clin & Mol Sci, Clin Dermatol, I-60126 Ancona, Italy.
   [Capodaglio, Irene] Ospedali Riuniti Ancona, Hosp Cardiol, I-60126 Ancona, Italy.
   [Capodaglio, Irene] Ospedali Riuniti Ancona, UTIC, I-60126 Ancona, Italy.
C3 Marche Polytechnic University
RP Rizzetto, G (corresponding author), Polytech Univ Marche, Dept Clin & Mol Sci, Clin Dermatol, I-60126 Ancona, Italy.
EM g.rizzetto@pm.univpm.it
RI MOLINELLI, ELISA/GVR-7592-2022
OI DE SIMONI, EDOARDO/0009-0007-8052-9324; Rizzetto,
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PU MDPI
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PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD APR
PY 2023
VL 15
IS 7
AR 1705
DI 10.3390/nu15071705
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA D6FG4
UT WOS:000969662900001
PM 37049545
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Kiecolt-Glaser, JK
   Jaremka, L
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AF Kiecolt-Glaser, Janice K.
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   Andridge, Rebecca
   Peng, Juan
   Habash, Diane
   Fagundes, Christopher P.
   Glaser, Ronald
   Matarkey, William B.
   Belury, Martha A.
TI Marital discord, past depression, and metabolic responses to high-fat
   meals: Interpersonal pathways to obesity
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE Marriage; Depression; Resting energy expenditure; Triglycerides;
   Insulin; Inflammation
ID NONFASTING TRIGLYCERIDES; CHRONIC STRESS; POSTPRANDIAL LIPEMIA;
   CARDIOVASCULAR RISK; ENERGY-EXPENDITURE; HEART-DISEASE; OLDER-ADULTS;
   HEALTHY; QUALITY; WOMEN
AB Background: Longitudinal studies have implicated both marital distress and depression in the development of the metabolic syndrome, a risk factor for diabetes and cardiovascular disease. This study addressed the impact of hostile marital interactions and a mood disorder history on obesity-related metabolic responses to high-fat meals.
   Methods: This double-blind, randomized crossover study included serial assessments of resting energy expenditure (REE), fat and carbohydrate oxidation, triglycerides, insulin, glucose, interleukin 6 (IL-6), and tumor necrosis factor alpha (TNF-alpha) before and after two high-fat meals. During two separate 9.5 h visits, 43 healthy married couples, ages 24-61 (mean = 38.22), received either a high saturated fat meal or a high oleic sunflower oil meal, both 930 kcal and 60 g fat. The Structured Diagnostic Interview for DSM-IV assessed mood disorder history. Couples discussed a marital disagreement during both visits; behavioral coding of these interactions provided data on hostile marital behaviors.
   Results: Men and women who displayed more hostile behaviors and who also had a mood disorder history had significantly lower post-meal REE, higher insulin, and higher peak triglyceride responses than other participants, with nonsignificant effects for fat and carbohydrate oxidation. Participants with a mood disorder history had a steeper rise in postprandial IL-6 and glucose than those without a past history. Higher levels of hostile behaviors were associated with higher post-meal TNF-alpha. The two meals did not differ on any outcome assessed.
   Conclusions: People spend about 18 of every 24 h in a postprandial state, and dining with one's partner is a common daily event. Among subjects with a mood disorder history, the cumulative 6.75-h difference between high and low hostile behaviors translates into 128 kcal, a difference that could add 7.6 pounds/year. Our findings illustrate novel pathways through which chronic marital stress and a mood disorder history synergistically heighten the risk for obesity, metabolic syndrome, and cardiovascular disease. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Kiecolt-Glaser, Janice K.; Glaser, Ronald; Matarkey, William B.] Ohio State Univ, Coll Med, Inst Behav Med Res, Columbus, OH 43210 USA.
   [Kiecolt-Glaser, Janice K.; Matarkey, William B.] Ohio State Univ, Med Ctr, Dept Psychiat, Columbus, OH 43210 USA.
   [Jaremka, Lisa] Univ Delaware, Dept Psychol & Brain Sci, Newark, DE 19716 USA.
   [Andridge, Rebecca; Peng, Juan] Ohio State Univ, Coll Publ Hlth, Div Biostat, Columbus, OH 43210 USA.
   [Habash, Diane] Ohio State Univ, Med Ctr, Columbus, OH 43210 USA.
   [Fagundes, Christopher P.] Univ Texas Houston, MD Anderson Canc Ctr, Dept Hlth Dispar Res, Houston, TX 77030 USA.
   [Matarkey, William B.] Ohio State Univ, Med Ctr, Dept Med, Columbus, OH 43210 USA.
   [Belury, Martha A.] Ohio State Univ, Coll Educ & Human Ecol, Dept Human Sci, Columbus, OH 43210 USA.
C3 University System of Ohio; Ohio State University; University System of
   Ohio; Ohio State University; University of Delaware; University System
   of Ohio; Ohio State University; University System of Ohio; Ohio State
   University; University of Texas System; UTMD Anderson Cancer Center;
   University of Texas Health Science Center Houston; University System of
   Ohio; Ohio State University; University System of Ohio; Ohio State
   University
RP Kiecolt-Glaser, JK (corresponding author), Ohio State Univ, Coll Med, Inst Behav Med Res, 460 Med Ctr Dr, Columbus, OH 43210 USA.
EM Janice.Kiecolt-Glaser@osumc.edu
RI Habash, Diane/E-3180-2011; Andridge, Rebecca/C-8457-2012
OI Andridge, Rebecca/0000-0001-9991-9647
FU National Institute of Health (NIH) [CA158868, CA172296, UL1RR025755,
   CA016058]; American Cancer Society [121911-PF-12-040-01-CPPB]
FX The study was supported in part by National Institute of Health (NIH)
   Grants CA158868, CA172296, UL1RR025755, and CA016058, as well as
   American Cancer Society Post-doctoral Fellowship Grant
   121911-PF-12-040-01-CPPB. The sponsors had no role in the design and
   conduct of the study; collection, management, analysis, and
   interpretation of the data; and preparation, review, or approval of the
   manuscript.
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NR 77
TC 54
Z9 67
U1 0
U2 17
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD FEB
PY 2015
VL 52
BP 239
EP 250
DI 10.1016/j.psyneuen.2014.11.018
PG 12
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA CA9UT
UT WOS:000349271000022
PM 25506778
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Reynolds, AC
   Paterson, JL
   Ferguson, SA
   Stanley, D
   Wright, KP
   Dawson, D
AF Reynolds, Amy C.
   Paterson, Jessica L.
   Ferguson, Sally A.
   Stanley, Dragana
   Wright, Kenneth P., Jr.
   Dawson, Drew
TI The shift work and health research agenda: Considering changes in gut
   microbiota as a pathway linking shift work, sleep loss and circadian
   misalignment, and metabolic disease
SO SLEEP MEDICINE REVIEWS
LA English
DT Review
DE Gut microbiota; Microbiome; Shift work; Sleep disruption; Circadian
   disruption
ID IMPAIRED GLUCOSE-TOLERANCE; RISK-FACTOR; INSULIN SENSITIVITY;
   INFLAMMATORY MARKERS; ENERGY-EXPENDITURE; DIABETES-MELLITUS; GHRELIN
   LEVELS; QUEBEC FAMILY; LEPTIN LEVELS; FOOD-INTAKE
AB Prevalence and impact of metabolic disease is rising. In particular, overweight and obesity are at epidemic levels and are a leading health concern in the Western world. Shift work increases the risk of overweight and obesity, along with a number of additional metabolic diseases, including metabolic syndrome and type 2 diabetes (T2D). How shift work contributes to metabolic disease has not been fully elucidated. Short sleep duration is associated with metabolic disease and shift workers typically have shorter sleep durations. Short sleep durations have been shown to elicit a physiological stress response, and both physiological and psychological stress disrupt the healthy functioning of the intestinal gut microbiota. Recent findings have shown altered intestinal microbial communities and dysbiosis of the gut microbiota in circadian disrupted mice and jet lagged humans. We hypothesize that sleep and circadian disruption in humans alters the gut microbiota, contributing to an inflammatory state and metabolic disease associated with shift work. A research agenda for exploring the relationship between insufficient sleep, circadian misalignment and the gut microbiota is provided. (C) 2016 Elsevier Ltd. All rights reserved.
C1 [Reynolds, Amy C.; Paterson, Jessica L.; Ferguson, Sally A.; Dawson, Drew] Cent Queensland Univ, Appleton Inst, 44 Greenhill Rd, Wayville, SA 5034, Australia.
   [Stanley, Dragana] Cent Queensland Univ, Bruce Highway, Rockhampton, Qld 4702, Australia.
   [Wright, Kenneth P., Jr.] Univ Colorado, Dept Integrat Physiol, Sleep & Chronobiol Lab, Boulder, CO 80309 USA.
C3 Central Queensland University; Central Queensland University; University
   of Colorado System; University of Colorado Boulder
RP Reynolds, AC (corresponding author), Cent Queensland Univ, Appleton Inst, 44 Greenhill Rd, Wayville, SA 5034, Australia.
EM a.reynolds@cqu.edu.au
RI Stanley, Dragana/AAC-2596-2020; Reynolds, Amy/Y-8497-2019
OI Stanley, Dragana/0000-0001-7019-4726; Dawson, Drew/0000-0001-7385-5630;
   Paterson, Jessica/0000-0001-5420-4664; Ferguson,
   Sally/0000-0002-9682-7971; Reynolds, Amy/0000-0001-9534-8699
FU Australian Research Council [DP150104497, DP160104909, DP130104843,
   LP130101100, DE160101470]; Office of Naval Research [N00014-15-1-2809];
   NIH [HL109706, HL131458, HL111478]; Philips, Inc; Torvec, Inc.;
   Freemasons Foundation Trevor Prescott Memorial Scholarship; Australian
   Research Council [LP130101100, DE160101470] Funding Source: Australian
   Research Council
FX Professor Sally Ferguson, Professor Drew Dawson and Dr Dragana Stanley
   are engaged in research supported by a number of Australian Research
   Council grants (DP150104497, DP160104909, DP130104843, LP130101100,
   DE160101470). Professor Kenneth Wright is presently supported by Office
   of Naval Research N00014-15-1-2809 and NIH HL109706, HL131458, HL111478,
   Philips, Inc and Torvec, Inc. Dr Amy Reynolds has received funding from
   the Freemasons Foundation Trevor Prescott Memorial Scholarship. The
   Appleton Institute (Reynolds, Paterson, Ferguson and Dawson) has a
   research relationship with commercial organization uBiome, but receives
   no financial funding from this company.
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NR 92
TC 100
Z9 113
U1 2
U2 60
PU W B SAUNDERS CO LTD
PI LONDON
PA 32 JAMESTOWN RD, LONDON NW1 7BY, ENGLAND
SN 1087-0792
EI 1532-2955
J9 SLEEP MED REV
JI Sleep Med. Rev.
PD AUG
PY 2017
VL 34
BP 3
EP 9
DI 10.1016/j.smrv.2016.06.009
PG 7
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA FA3UJ
UT WOS:000405369600002
PM 27568341
DA 2025-06-11
ER

PT J
AU Busserolles, J
   Mazur, A
   Gueux, E
   Rock, E
   Rayssiguier, Y
AF Busserolles, J
   Mazur, A
   Gueux, E
   Rock, E
   Rayssiguier, Y
TI Metabolic syndrome in the rat: Females are protected against the
   pro-oxidant effect of a high sucrose diet
SO EXPERIMENTAL BIOLOGY AND MEDICINE
LA English
DT Article
DE metabolic syndrome; high-sucrose diet; oxidative stress; gender; rat
ID INSULIN SENSITIVITY; COPPER DEFICIENCY; ANTIOXIDANT; FRUCTOSE; ESTROGEN;
   PEROXIDATION; RESISTANCE; MORTALITY
AB Metabolic syndrome is more prevalent in men than in women. In an experimental dietary model of metabolic syndrome, the high-fructose-fed rat, oxidative stress has been observed in males. Given that estradiol has been documented to exert an antioxidant effect, we investigated whether female rats were better protected than males against the adverse effects of a high-sucrose diet, and we studied the Influence of hormonal status in female rats. Males and females were first fed a sucrose-based or starch-based diet for 2 weeks. In the males, the plasma triglyceride (TG)-raising effect of sucrose was accompanied by significantly lowered plasma a-tocopherol and a significantly lowered alpha-tocopherol/TG ratio (30%), suggesting that vitamin E depletion may predispose lipoproteins to subsequent oxidative stress. In males, after exposure of heart tissue homogenate to iron-induced lipid peroxidation, thiobarbituric reactive substances were significantly higher in the sucrose-fed than in the starch-fed rats. In contrast, in sucrose-fed females, neither a decrease In vitamin E/TG ratio nor an increased susceptibility of heart tissue to peroxidation was observed, despite both a significantly decreased heart superoxide dismutase activity (14%) and a significant 3-fold increase in plasma nitric oxide concentration compared with starch-fed females, The influence of hormonal status in female rats was then assessed using intact, ovariectomized, or estradiol-supplemented ovariectomized female rats fed the sucrose or starch diet for 2 weeks. After exposure of heart tissue to iron-induced lipid peroxidation, higher susceptibility to peroxidation was found only in ovariectomized females fed the sucrose diet compared with the starch group and not in intact females or ovariectomized females supplemented with estradiol. Thus, estrogens, by their effects on antioxidant capacity, might explain the sexual difference in the pro-oxidant effect of sucrose diet resulting in metabolic syndrome in rats.
C1 INRA, Ctr Rech Nutr Humaine Auvergne, Unite Malad Metab & Micronutriments, F-63122 St Genes Champanelle, France.
C3 INRAE
RP INRA, Ctr Rech Nutr Humaine Auvergne, Unite Malad Metab & Micronutriments, F-63122 St Genes Champanelle, France.
EM yves.rayssiguier@clermont.inra.fr
RI Mazur, Andre/AAG-9751-2020; Busserolles, Jerome/K-4232-2014
OI Mazur, Andre/0000-0002-1067-5066; Busserolles,
   Jerome/0000-0001-7542-9520
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NR 44
TC 56
Z9 64
U1 0
U2 1
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1535-3702
EI 1535-3699
J9 EXP BIOL MED
JI Exp. Biol. Med.
PD OCT
PY 2002
VL 227
IS 9
BP 837
EP 842
DI 10.1177/153537020222700918
PG 6
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 595TB
UT WOS:000178123900018
PM 12324666
DA 2025-06-11
ER

PT J
AU Roberts, CK
   Barnard, RJ
   Sindhu, RK
   Jurczak, M
   Ehdaie, A
   Vaziri, ND
AF Roberts, Christian K.
   Barnard, R. James
   Sindhu, Ram K.
   Jurczak, Michael
   Ehdaie, Ashkan
   Vaziri, Nosratola D.
TI Oxidative stress and dysregulation of NAD(P)H oxidase and antioxidant
   enzymes in diet-induced metabolic syndrome
SO METABOLISM-CLINICAL AND EXPERIMENTAL
LA English
DT Article
ID REFINED-CARBOHYDRATE DIET; LEAD-INDUCED HYPERTENSION; C-REACTIVE
   PROTEIN; OBESE ZUCKER RAT; CARDIOVASCULAR-DISEASE; INSULIN-RESISTANCE;
   NADPH OXIDASE; ENDOTHELIAL DYSFUNCTION; SUPEROXIDE-PRODUCTION; DEPENDENT
   RELAXATION
AB Previously, we have demonstrated that chronic consumption of a high-fat, high-refined sugar (HFS) diet results in metabolic syndrome which is marked by obesity, insulin resistance, hyperlipidemia, and hypertension in Fischer rats. Metabolic syndrome in this model is associated with oxidative stress, avid nitric oxide (NO) inactivation by reactive oxygen species (ROS), diminished NO bioavailability, and dysregulation of NO synthase isotypes. Although occurrence of oxidative stress and its impact on NO metabolism are well established, the molecular source(s) of ROS in this model is unknown. In an attempt to explore this issue, we measured protein expressions of the key ROS-producing enzyme, NAD(P)H oxidase, and the main antioxidant enzymes, superoxide dismutase (CuZn SOD and Mn SOD), catalase, glutathione peroxidase (GPX), and heme oxygenase-2 (HO-2), in the kidney and aorta of Fischer rats fed an HFS or low-fat, complex-carbohydrate diet for 7 months. In addition, plasma lipid peroxidation product (malondialdehyde) as well as endothelium-dependent and independent vasorelaxation (aorta rings) was determined. The results showed a significant upregulation of gp91(phox) subunit of NAD(P)H oxidase and downregulations of SOD isoforms, GPX, and HO-2 in the kidney and aorta of the HFS-fed animals. This was associated with increased plasma malondialdehyde concentration and impaired vasodilatory response to acetylcholine, but not the NO donor, Na nitroprusside. The latter findings confirm the presence of oxidative stress and endothelial dysfunction in the HFS-fed rats. Oxidative stress and endothelial dysfunction in the diet-induced metabolic syndrome are accompanied by upregulation of NAD(P)H oxidase, pointing to increased ROS production capacity, and downregulation of SOD isoforms, GPX, and HO-2, the key enzymes in the antioxidant defense system. (c) 2006 Elsevier Inc. All rights reserved.
C1 Univ Calif Irvine, Dept Med, Div Nephrol & Hypertens, Orange, CA 92697 USA.
   Univ Calif Los Angeles, Dept Physiol Sci, Los Angeles, CA 90095 USA.
   Charles R Drew Univ, Div Endocrinol Metab & Mol Med, Los Angeles, CA 90095 USA.
   Univ Calif Irvine, Dept Physiol & Biophys, Irvine, CA 92697 USA.
C3 University of California System; University of California Irvine;
   University of California System; University of California Los Angeles;
   Charles R. Drew University of Medicine & Science; University of
   California System; University of California Irvine
RP Vaziri, ND (corresponding author), Univ Calif Irvine, Dept Med, Div Nephrol & Hypertens, Orange, CA 92668 USA.
EM ndvaziri@uci.edu
OI Jurczak, Michael/0000-0002-6335-6915
FU NHLBI NIH HHS [F32 HL68406-01] Funding Source: Medline
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NR 41
TC 257
Z9 278
U1 0
U2 16
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0026-0495
EI 1532-8600
J9 METABOLISM
JI Metab.-Clin. Exp.
PD JUL
PY 2006
VL 55
IS 7
BP 928
EP 934
DI 10.1016/j.metabol.2006.02.022
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 058VC
UT WOS:000238691700013
PM 16784966
DA 2025-06-11
ER

PT J
AU Beydoun, MA
   Kuczmarski, MTF
   Mason, MA
   Ling, SM
   Evans, MK
   Zonderman, AB
AF Beydoun, May A.
   Kuczmarski, Marie T. Fanelli
   Mason, Marc A.
   Ling, Shari M.
   Evans, Michele K.
   Zonderman, Alan B.
TI Role of depressive symptoms in explaining socioeconomic status
   disparities in dietary quality and central adiposity among US adults: a
   structural equation modeling approach
SO AMERICAN JOURNAL OF CLINICAL NUTRITION
LA English
DT Article
ID BODY-MASS INDEX; MULTIPLE-PASS METHOD; WAIST-HIP RATIO;
   HYPERCORTISOLEMIC DEPRESSION; ADOLESCENT DEPRESSION; ABDOMINAL
   ADIPOSITY; CARDIOVASCULAR RISK; METABOLIC SYNDROME; FAT DISTRIBUTION;
   ENERGY-DENSITY
AB Background: The link between socioeconomic status (SES), depression, dietary quality, and central adiposity remains unclear.
   Objective: Pathways linking SES to dietary quality and central adiposity through depressive symptoms were examined across sex-ethnicity groups.
   Design: Extensive data on US adults aged 30-64 y from the Healthy Aging in Neighborhoods of Diversity across the Life Span (HANDLS) study were used in multiple linear logistic regression models and structural equation models to test pathway associations. Measures included Center for Epidemiologic Studies-Depression (CES-D) scores, 2005 Healthy Eating Index (HEI) values, and dual-energy X-ray absorptiometry. Sample sizes for most analyses ranged between 1789 for anthropometric outcomes and 1227 for trunk fat outcomes.
   Results: The CES-D score was associated with lower HEI scores in all sex-ethnicity groups, except in African American men, and with higher waist-to-hip ratios (WHRs) among African American women. A CES-D score >= 16 was positively associated with waist circumference (WC) and with trunk fat among white women and men, respectively. SES was positively related to central adiposity among African American men (central obesity and WC) and African American women (central obesity and percentage trunk fat) but was inversely related to central adiposity among white women. Among whites only, the total positive effect of SES on HEI was significantly mediated by CES-D score. Among white women, the total inverse effect of SES on WC and WHR was significantly explained by the CES-D score and HEI, whereas the CES-D score was positively associated with WHR among African American women, independently of SES.
   Conclusion: Future mental health interventions targeted at reducing SES disparities in dietary quality and central adiposity may have different effects across sex-ethnicity groups. Am J Clin Nutr 2009;90:1084-95.
C1 [Beydoun, May A.] NIA, NIH, Biomed Res Ctr, Lab Personal & Cognit,Intramural Res Program, Baltimore, MD 21224 USA.
   [Ling, Shari M.; Evans, Michele K.] NIA, Clin Res Branch, NIH, Intramural Res Program, Baltimore, MD 21224 USA.
   [Kuczmarski, Marie T. Fanelli] Univ Delaware, Dept Hlth Nutr & Exercise Sci, Newark, DE USA.
   [Mason, Marc A.] MedStar Res Inst, Baltimore, MD USA.
C3 National Institutes of Health (NIH) - USA; NIH National Institute on
   Aging (NIA); National Institutes of Health (NIH) - USA; NIH National
   Institute on Aging (NIA); University of Delaware
RP Beydoun, MA (corresponding author), NIA, NIH, Biomed Res Ctr, Lab Personal & Cognit,Intramural Res Program, IRP 251,Bayview Blvd,Suite 100,Room 04B118, Baltimore, MD 21224 USA.
EM baydounm@mail.nih.gov
RI Evans, Michele/AAE-4776-2019; Zonderman, Alan/A-5807-2013
OI Zonderman, Alan B/0000-0002-6523-4778; Evans,
   Michele/0000-0002-8546-2831
FU Intramural Research Program of the NIH; National Institute on Aging
FX Supported entirely by the Intramural Research Program of the NIH,
   National Institute on Aging.
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NR 96
TC 54
Z9 65
U1 1
U2 16
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0002-9165
EI 1938-3207
J9 AM J CLIN NUTR
JI Am. J. Clin. Nutr.
PD OCT 1
PY 2009
VL 90
IS 4
BP 1084
EP 1095
DI 10.3945/ajcn.2009.27782
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nutrition & Dietetics
GA 496GC
UT WOS:000269956700026
PM 19710191
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Mihalas, E
   Serban, LI
   Matei, D
   Cascaval, D
   Galaction, AI
AF Mihalas, Elvina
   Serban, Lacramioara Ionela
   Matei, Daniela
   Cascaval, Dan
   Galaction, Anca Irina
TI CHANGES OF OXIDATIVE STRESS CAUSED BY PHYSICAL ACTIVITY
SO STUDIA UNIVERSITATIS BABES-BOLYAI CHEMIA
LA English
DT Article
DE Free radicals; reactive oxygen species; oxidative stress; metabolic
   syndrome; aerobic exercises; anaerobic exercises; antioxidant system
ID ENDOTHELIAL FUNCTION; ANAEROBIC EXERCISE; NITRIC-OXIDE; ANTIOXIDANT;
   MARKERS; IMPACT; ADAPTATIONS; MODULATION; BIOMARKERS; MARATHON
AB Free radicals and reactive oxygen species are produced in the human body as a part of metabolic processes. Reactive species in low levels are important for cellular activities. Excessive amounts of reactive species can be harmful because they can produce lipid peroxidation, proteins and ADN oxidation. For reduce these harmful effects the organism requires an antioxidant defence. Oxidative stress is involve in atherosclerosis, coronary heart disease, metabolic syndrome, type 2 diabetes mellitus. The aerobic and anaerobic exercises have different effects on the muscles, but both influence positively the biomarkers of oxidative stress. Studies prove that aerobics increase endogenous antioxidant status. Regular moderate exercises produce an increase in antioxidant activity, due to the changes in redox homeostasis. The aim of this review is to discuss the importance of a constant physical activity for increase the body's antioxidant system and to protect against oxidative stress.
C1 [Mihalas, Elvina; Cascaval, Dan] Gheorghe Asachi Tech Univ Iasi, Fac Chem Engn & Environm Protect, 73 D Mangeron Str, RO-700050 Iasi, Romania.
   [Serban, Lacramioara Ionela] Grigore T Popa Univ Med & Pharm Iasi, Fac Med, 16 Univ Str, RO-700115 Iasi, Romania.
   [Mihalas, Elvina; Matei, Daniela; Galaction, Anca Irina] Grigore T Popa Univ Med & Pharm Iasi, Fac Med Bioengn, 9-13 M Kogalniceanu Str, RO-700454 Iasi, Romania.
C3 GH Asachi Technical University; Grigore T Popa University of Medicine &
   Pharmacy; Grigore T Popa University of Medicine & Pharmacy
RP Matei, D (corresponding author), Grigore T Popa Univ Med & Pharm Iasi, Fac Med Bioengn, 9-13 M Kogalniceanu Str, RO-700454 Iasi, Romania.
EM daniela.matei@umfiasi.ro
RI Mihalaş, Elvina/AAP-1251-2021; Galaction, Anca/MTC-4512-2025
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NR 44
TC 3
Z9 3
U1 0
U2 10
PU UNIV BABES-BOLYAI
PI CLUJ-NAPOCA
PA MIHAIL KOGALNICEANU NR. 1, CLUJ-NAPOCA RO-3400, ROMANIA
SN 1224-7154
J9 STUD U BABES-BOL CHE
JI Stud. Univ. Babes-Bolyai Chem.
PY 2019
VL 64
IS 2
BP 35
EP 47
DI 10.24193/subbchem.2019.2.03
PN 1
PG 13
WC Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry
GA IM2IK
UT WOS:000477816000004
OA gold
DA 2025-06-11
ER

PT J
AU Stirban, A
   Negrean, M
   Stratmann, B
   Götting, C
   Salomon, J
   Kleesiek, K
   Tschoepe, D
AF Stirban, Alin
   Negrean, Monica
   Stratmann, Bernd
   Goetting, Christian
   Salomon, Julia
   Kleesiek, Knut
   Tschoepe, Diethelm
TI Adiponectin decreases postprandially following a heat-processed meal in
   individuals with type 2 diabetes -: An effect prevented by benfotiammie
   and cookmig method
SO DIABETES CARE
LA English
DT Article
ID GLYCATION END-PRODUCTS; INSULIN-RESISTANCE; ENDOTHELIAL DYSFUNCTION;
   PLASMA ADIPONECTIN; METABOLIC SYNDROME; OXIDATIVE STRESS;
   ADIPOSE-TISSUE; ADIPOCYTES; MELLITUS; GLYCOXIDATION
C1 Ruhr Univ Bochum, Ctr Diabet, Heart & Diabetes Ctr, NRW, Bad Oeynhausen, Germany.
   Ruhr Univ Bochum, Inst Lab Transfus Med, Heart & Diabetes Ctr, NRW, Bad Oeynhausen, Germany.
   Univ Appl Sci, Munster, Germany.
C3 Ruhr University Bochum; Ruhr University Bochum; University of Applied
   Sciences, Muenster
RP Tschoepe, D (corresponding author), Heart & Diabetes Ctr, NRW, Georgstrasse 11, D-32545 Bad Oeynhausen, Germany.
EM dtschoepe@hdz-nr-w.de
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NR 31
TC 24
Z9 27
U1 0
U2 6
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0149-5992
J9 DIABETES CARE
JI Diabetes Care
PD OCT
PY 2007
VL 30
IS 10
BP 2514
EP 2516
DI 10.2337/dc07-0302
PG 3
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 221JN
UT WOS:000250223400019
PM 17630265
OA Bronze
DA 2025-06-11
ER

PT J
AU Patel, RS
   Majumder, P
   Correll, CU
AF Patel, Rikinkumar S. S.
   Majumder, Pradipta
   Correll, Christoph U. U.
TI Characteristics and Correlates of Metabolic Syndrome in Adolescents with
   Unipolar and Bipolar Depression: Results from a Cross-National Inpatient
   Case-Control Study
SO JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY
LA English
DT Article
DE major depression; bipolar depression; metabolic syndrome; metabolic
   comorbidities; risk factors; adolescents
ID PSYCHOTIC DISORDERS; SYNDROME PHENOTYPE; WEIGHT-GAIN; PREVALENCE;
   OBESITY; METAANALYSIS; ASSOCIATION; ADULTS; HEALTH; TRENDS
AB Objectives: To assess characteristics and correlates of metabolic syndrome (MetS) in adolescents with major depressive disorder (MDD) or bipolar disorder-depressive episode (BP-d).
   Methods: Case-control study, using national inpatient sample data, including adolescents (age, 12-18 years) with a primary diagnosis of MDD or BP-d. Using propensity score matching (based on age, sex, and race/ethnicity), we extracted cases with MetS (>= 3 of the following conditions: obesity, diabetes, hypercholesterolemia, and hypertension) and controls without MetS. We used a multivariable logistic regression model calculating adjusted odds ratios (aORs) for potential correlates of MetS, focusing on primary mood disorders and psychiatric comorbidities.
   Results: In 607 age-/sex-/race/ethnicity-matched adolescents (MDD = 83.5%, BP-d = 16.5%), comparing those with (N = 332) versus without MetS (N = 275), MetS was most prevalent in later-age adolescents (mean age 16.3 years), females (58.1%), Whites (40.3%), and Blacks (31.5%). MetS was characterized by obesity (84.9% vs. 3.6%), hypertension (81% vs. 1.8%), diabetes (72.8% vs. 9.1%), and hypercholesterolemia (67.2% vs. 3.6%) (all p < 0.001). MetS was associated with a primary diagnosis of BP-d versus MDD (aOR 2.42, 95% confidence interval [CI] 1.47-3.97) and comorbid disruptive behavior disorders (DBD) (aOR 4.45, 95% CI 1.55-12.78), while comorbid substance use disorder reduced MetS risk (aOR 0.31, 95% CI 0.19-0.50).
   Conclusion: In adolescents with MDD or BP-d, MetS was associated with a primary BP-d diagnosis, and comorbid DBD. MetS-related parameters should be screened for early in adolescents with depression-spectrum disorders aiming to prevent the development or effects of MetS.
C1 [Patel, Rikinkumar S. S.] Duke Univ, Dept Child & Adolescent Psychiat, Med Ctr, Durham, NC 27708 USA.
   [Majumder, Pradipta] Dept Psychiat, WellSpan Hlth, York, PA USA.
   [Majumder, Pradipta] Drexel Univ, Dept Behav Hlth, Coll Med, Philadelphia, PA USA.
   [Correll, Christoph U. U.] Zucker Hillside Hosp, Dept Psychiat, Northwell Hlth, Glen Oaks, NY USA.
   [Correll, Christoph U. U.] Donald & Barbara Zucker Sch Med Hofstra Northwell, Dept Psychiat & Mol Med, Hempstead, NY USA.
   [Correll, Christoph U. U.] Charite Univmed Berlin, Dept Child & Adolescent Psychiat, Berlin, Germany.
C3 Duke University; Drexel University; Northwell Health; Northwell Health;
   Berlin Institute of Health; Free University of Berlin; Humboldt
   University of Berlin; Charite Universitatsmedizin Berlin
RP Patel, RS (corresponding author), Duke Univ, Dept Child & Adolescent Psychiat, Med Ctr, Durham, NC 27708 USA.
EM dr.rknpatel@gmail.com
RI Correll, Christoph/D-3530-2011; Majumder, Pradipta/ABD-9262-2020; Patel,
   Rikinkumar/J-7277-2019
OI Patel, Rikinkumar/0000-0002-2895-9155
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NR 63
TC 1
Z9 1
U1 1
U2 1
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1044-5463
EI 1557-8992
J9 J CHILD ADOL PSYCHOP
JI J. Child Adolesc. Psychopharmacol.
PD OCT 1
PY 2022
VL 32
IS 8
BP 426
EP 433
DI 10.1089/cap.2022.0017
PG 8
WC Pediatrics; Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics; Pharmacology & Pharmacy; Psychiatry
GA 5U2ST
UT WOS:000876404000002
PM 36282769
DA 2025-06-11
ER

PT J
AU Cisternas, P
   Salazar, P
   Serrano, FG
   Montecinos-Oliva, C
   Arredondo, SB
   Varela-Nallar, L
   Barja, S
   Vio, CP
   Gomez-Pinilla, F
   Inestrosa, NC
AF Cisternas, Pedro
   Salazar, Paulina
   Serrano, Felipe G.
   Montecinos-Oliva, Carla
   Arredondo, Sebastian B.
   Varela-Nallar, Lorena
   Barja, Salesa
   Vio, Carlos P.
   Gomez-Pinilla, Fernando
   Inestrosa, Nibaldo C.
TI Fructose consumption reduces hippocampal synaptic plasticity underlying
   cognitive performance
SO BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
LA English
DT Article
DE Fructose; Diabetes; Metabolic syndrome; Neuronal dysfunction
ID HOMEOSTASIS MODEL ASSESSMENT; CEREBRAL-BLOOD-FLOW; OPEN-FIELD TEST;
   METABOLIC SYNDROME; ALZHEIMERS-DISEASE; OXIDATIVE STRESS; ADULT
   NEUROGENESIS; HIGH-FAT; GLUCOSE-TRANSPORTER; INSULIN-RESISTANCE
AB Metabolic syndrome (MetS) is a global epidemic, which involves a spectrum of metabolic disorders comprising diabetes and obesity. The impact of MetS on the brain is becoming to be a concern, however, the poor understanding of mechanisms involved has limited the development of therapeutic strategies. We induced a MetS-like condition by exposing mice to fructose feeding for 7 weeks. There was a dramatic deterioration in the capacity of the hippocampus to sustain synaptic plasticity in the forms of long-term potentiation (LTP) and long-term depression (LTD). Mice exposed to fructose showed a reduction in the number of contact zones and the size of postsynaptic densities (PSDs) in the hippocampus, as well as a decrease in hippocampal neurogenesis. There was an increase in lipid peroxidation likely associated with a deficiency in plasma membrane excitability. Consistent with an overall hippocampal dysfunction, there was a subsequent decrease in hippocampal dependent learning and memory performance, i.e., spatial learning and episodic memory. Most of the pathological sequel of MetS in the brain was reversed three month after discontinue fructose feeding. These results are novel to show that MetS triggers a cascade of molecular events, which disrupt hippocampal functional plasticity, and specific aspects of learning and memory function. The overall information raises concerns about the risk imposed by excessive fructose consumption on the pathology of neurological disorders. Crown Copyright (C) 2015 Published by Elsevier B.V. All rights reserved.
C1 [Cisternas, Pedro; Salazar, Paulina; Serrano, Felipe G.; Montecinos-Oliva, Carla; Vio, Carlos P.; Inestrosa, Nibaldo C.] Pontificia Univ Catolica Chile, Fac Ciencias Biol, Cent Envejecimiento Regenerac CARE, Santiago, Chile.
   [Arredondo, Sebastian B.; Varela-Nallar, Lorena] Univ Andres Bello, Fac Biol Sci, Ctr Biomed Res, Santiago, Chile.
   [Arredondo, Sebastian B.; Varela-Nallar, Lorena] Univ Andres Bello, Fac Med, Santiago, Chile.
   [Barja, Salesa] Pontificia Univ Catolica Chile, Fac Med, Dept Pediat, Santiago, Chile.
   [Gomez-Pinilla, Fernando] Univ Calif Los Angeles, Dept Integrat Biol & Physiol, Los Angeles, CA USA.
   [Inestrosa, Nibaldo C.] Univ New S Wales, Fac Med, Sch Psychiat, Ctr Healthy Brain Ageing, Sydney, NSW, Australia.
   [Inestrosa, Nibaldo C.] Univ Magallanes, Cent Excelencia Biomed Magallanes CEBIMA, Punta Arenas, Chile.
   [Inestrosa, Nibaldo C.] Catholic Univ Chile, Cent UC Sindrome Down, Santiago, Chile.
C3 Pontificia Universidad Catolica de Chile; Universidad Andres Bello;
   Universidad Andres Bello; Pontificia Universidad Catolica de Chile;
   University of California System; University of California Los Angeles;
   University of New South Wales Sydney; Universidad de Magallanes;
   Pontificia Universidad Catolica de Chile
RP Inestrosa, NC (corresponding author), Pontificia Univ Catolica Chile, Fac Biol Sci, CARE Biomed Ctr, Alameda 340 POB 114 D, Santiago, Chile.
EM ninestrosa@bio.puc.cl
RI Arredondo, Sebastian/AHB-4503-2022; Vio, Carlos/JAX-7281-2023;
   Varela-Nallar, Lorena/AAV-3304-2021; Barja, Salesa/AGU-0677-2022
OI CISTERNAS, PEDRO/0000-0001-7796-8982; Barja, Salesa/0000-0001-8583-188X;
   Serrano, Felipe/0000-0003-1362-8561; Montecinos-Oliva,
   Carla/0000-0002-6808-818X; Arredondo, Sebastian/0000-0002-9824-6898;
   Vio, Carlos/0000-0003-1850-5958; Varela-Nallar,
   Lorena/0000-0003-2588-6437
FU Basal Center of Excellence in Aging and Regeneration (CONICYT-PFB)
   [12/2007]; FONDECYT [1120156, 1130747, 1150933, 3150475]; NIH [R01
   NS50465]; Sociedad Quimica y Minera de Chile (SQM)
FX This work was supported by grants from the Basal Center of Excellence in
   Aging and Regeneration (CONICYT-PFB 12/2007) to N.C.I. and C.P.V.
   FONDECYT (no. 1120156) to N.C.I., FONDECYT (no. 1130747) to C.P.V.,
   FONDECYT (no. 1150933) to L.V.N. and the NIH (no. R01 NS50465) to F.G.P.
   As well a postdoctoral fellowship from FONDECYT (no. 3150475) to P.C. We
   also thank to Sociedad Quimica y Minera de Chile (SQM) for special
   grants "The role of K+ on Hypertension and Cognition" and "The role of
   lithium in human health and disease".
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NR 77
TC 60
Z9 66
U1 0
U2 26
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0925-4439
EI 1879-260X
J9 BBA-MOL BASIS DIS
JI Biochim. Biophys. Acta-Mol. Basis Dis.
PD NOV
PY 2015
VL 1852
IS 11
BP 2379
EP 2390
DI 10.1016/j.bbadis.2015.08.016
PG 12
WC Biochemistry & Molecular Biology; Biophysics; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Cell Biology
GA CS5QJ
UT WOS:000362132700005
PM 26300486
OA Green Accepted, Green Published, Green Submitted, Bronze
DA 2025-06-11
ER

PT J
AU Chess-Williams, R
   Sellers, DJ
AF Chess-Williams, Russ
   Sellers, Donna J.
TI Pathophysiological Mechanisms Involved in Overactive Bladder/Detrusor
   Overactivity
SO CURRENT BLADDER DYSFUNCTION REPORTS
LA English
DT Article
DE Overactive bladder; Detrusor overactivity; Inflammation; Ischemia;
   Pathophysiology; Bladder perfusion
ID LOWER URINARY-TRACT; BLADDER OUTLET OBSTRUCTION; AGE-RELATED-CHANGES;
   METABOLIC SYNDROME; SMOOTH-MUSCLE; SYMPTOMS; INFLAMMATION; ISCHEMIA;
   WOMEN; DYSFUNCTION
AB Purpose of Review To examine the latest published findings on the pathophysiological mechanisms involved in the development of overactive bladder (OAB) and detrusor overactivity (DO), and to identify common pathways linked to the risk factors associated with these conditions.
   Recent Findings Evidence is accumulating, both clinical and experimental, that many of the factors linked to the development of OAB/DO, including ageing, bladder outlet obstruction, psychological stress, and obesity are associated with reduced bladder blood flow. This induces local tissue inflammation with cytokine release and enhanced oxidative stress, ultimately resulting in altered detrusor sensitivity, detrusor hypertrophy and fibrosis, together with afferent hypersensitivity. These mechanisms would explain the symptoms of urgency and frequency observed in OAB patients. Although not a characteristic of OAB, undetected low level bacterial infections of the bladder have been proposed to explain the OAB symptoms in patients resistant to standard treatments. In this condition, inflammatory responses without reductions in perfusion activate the inflammatory pathways.
   Summary Evidence is mounting that poor bladder perfusion and local inflammatory responses are central mechanisms involved in the development of OAB/DO. As our understanding of these pathophysiological mechanisms advances, new avenues for drug development will be identified and ultimately treatment may become more individualized depending on the particular pathway involved and the drugs available.
C1 [Chess-Williams, Russ; Sellers, Donna J.] Bond Univ, Fac Hlth Sci & Med, Ctr Urol Res, Univ Dr, Gold Coast, Qld, Australia.
C3 Bond University
RP Chess-Williams, R (corresponding author), Bond Univ, Fac Hlth Sci & Med, Ctr Urol Res, Univ Dr, Gold Coast, Qld, Australia.
EM rchesswi@bond.edu.au; dsellers@bond.edu.au
RI Chess-Williams, Russ/E-3905-2013
OI Chess-Williams, Russ/0000-0002-7991-4117
FU CAUL
FX Open Access funding enabled and organized by CAUL and its Member
   Institutions.
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NR 92
TC 12
Z9 13
U1 0
U2 4
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1931-7212
EI 1931-7220
J9 CURR BLADDER DYSFUNC
JI Curr. Bladder Dysfunct. Rep.
PD JUN
PY 2023
VL 18
IS 2
BP 79
EP 88
DI 10.1007/s11884-023-00690-x
EA FEB 2023
PG 10
WC Urology & Nephrology
WE Emerging Sources Citation Index (ESCI)
SC Urology & Nephrology
GA AS5J2
UT WOS:000940690300001
OA hybrid
DA 2025-06-11
ER

PT J
AU Lazich, I
   Sarafidis, P
   de Guzman, E
   Patel, A
   Oliva, R
   Bakris, G
AF Lazich, I.
   Sarafidis, P.
   de Guzman, E.
   Patel, A.
   Oliva, R.
   Bakris, G.
TI Effects of combining simvastatin with rosiglitazone on inflammation,
   oxidant stress and ambulatory blood pressure in patients with the
   metabolic syndrome: the SIROCO study
SO DIABETES OBESITY & METABOLISM
LA English
DT Article
DE adiponectin; ambulatory blood pressure; C-reactive protein; oxidant
   stress; rosiglitazone; simvastatin
ID TYPE-2 DIABETES-MELLITUS; C-REACTIVE PROTEIN; HIGH CARDIOVASCULAR RISK;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; GLYCEMIC CONTROL; NONTRADITIONAL
   MARKERS; PLASMA-CONCENTRATIONS; GLUCOSE-HOMEOSTASIS; STATIN THERAPY
AB Aim: Individually, statins and thiazolidinediones (TZDs) show positive effects on atherosclerosis progression in cellular and animal models as well as patients with diabetes; however, their combined effects have not been studied. This study examines the effects of simvastatin combined with rosiglitazone on vascular inflammation, oxidant stress, ambulatory blood pressure (BP) and other atherosclerotic factors in patients with the metabolic syndrome.
   Methods: This is a randomized, double blind, placebo-controlled study in 53 subjects with the metabolic syndrome. Participants were randomized to simvastatin 40 mg/day plus placebo vs. simvastatin 40 mg/day plus rosiglitazone 4 mg/day for 6 months. The primary endpoint was the between-group difference in high-sensitivity C-reactive protein (hs-CRP) and secondary variables including urinary isoprostanes, serum malondialdehyde (MDA), ambulatory BP, adiponectin, and lipid and glycaemic profiles.
   Results: At study end, the group randomized to the simvastatin/rosiglitazone combination had a greater reduction in hs-CRP of 1.33 mg/dl, (p = 0.029) and showed a trend for a greater reduction in urinary isoprostane (-39%), (p = 0.056) compared to simvastatin/placebo group. Changes in MDA levels did not differed between groups (p = 0.81). 24-h systolic blood pressure (SBP) also showed a 4.5 mmHg reduction at 6 months (p = 0.06). Adiponectin levels increased by 3.91 mu g/ml in the combination group over placebo, (p = 0.03) and blood glucose decreased in combination group vs. placebo.
   Conclusion: Our data show that patients with the metabolic syndrome given a statin/TZD combination manifest greater reductions in markers of vascular inflammation and oxidant stress, 24-h ambulatory BP and increases in adiponectin as well as improved glycaemic indices.
C1 [Lazich, I.; Sarafidis, P.; de Guzman, E.; Patel, A.; Oliva, R.; Bakris, G.] Univ Chicago, Pritzker Sch Med, Hypertens Dis Unit, Dept Med, Chicago, IL 60637 USA.
   [Sarafidis, P.] AHEPA Univ Hosp, Dept Med 1, Sect Nephrol & Hypertens, Thessaloniki, Greece.
C3 University of Chicago; Aristotle University of Thessaloniki; Ahepa
   University Hospital
RP Bakris, G (corresponding author), Univ Chicago, Pritzker Sch Med, Hypertens Dis Unit, Dept Med, 5841 S Maryland Ave,MC 1027, Chicago, IL 60637 USA.
EM gbakris@gmail.com
RI Sarafidis, Pantelis/AFO-2131-2022; Bakris, George/AFC-1168-2022
OI Sarafidis, Pantelis/0000-0002-9174-4018
FU Glaxo Smith Kline
FX The study was funded by an investigator-initiated (Drs P.S. and G.B.)
   grant awarded by Glaxo Smith Kline to the University of Chicago
   Hospitals. We would also like to thank Drs. James Sowers and Adam
   Whaley-Connell from the University of Missouri School of Medicine for
   running our isoprostane and malondialdehyde samples.
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NR 40
TC 18
Z9 21
U1 0
U2 2
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1462-8902
J9 DIABETES OBES METAB
JI Diabetes Obes. Metab.
PD FEB
PY 2012
VL 14
IS 2
BP 181
EP 186
DI 10.1111/j.1463-1326.2011.01510.x
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 872CO
UT WOS:000298784900010
PM 21955403
DA 2025-06-11
ER

PT J
AU Nagase, M
   Matsui, H
   Shibata, S
   Gotoda, T
   Fujita, T
AF Nagase, Miki
   Matsui, Hiromitsu
   Shibata, Shigeru
   Gotoda, Takanari
   Fujita, Toshiro
TI Salt-induced nephropathy in obese spontaneously hypertensive rats via
   paradoxical activation of the mineralocorticoid receptor - Role of
   oxidative stress
SO HYPERTENSION
LA English
DT Article
DE aldosterone; mineralocorticoids; metabolic syndrome; sodium; dietary;
   oxidative stress (kidney); chronic kidney disease; proteinuria;
   eplerenone
ID PROGRESSIVE RENAL-DISEASE; METABOLIC SYNDROME; SUPEROXIDE-DISMUTASE;
   ALDOSTERONE BLOCKADE; PLASMA-ALDOSTERONE; GLOMERULAR INJURY; PODOCYTE
   INJURY; SGK1; INHIBITOR-1; ASSOCIATION
AB Aldosterone is implicated in the pathogenesis of proteinuria and chronic kidney disease. We previously demonstrated the contribution of elevated serum aldosterone in the early nephropathy of SHR/NDmcr-cp (SHR/cp), a rat model of metabolic syndrome. In the present study, we investigated the effect of salt loading on renal damage in SHR/cps and explored the underlying mechanisms. SHR/cps fed a high-sodium diet for 4 weeks developed severe hypertension, massive proteinuria, and advanced renal lesions. High salt also worsened glomerular podocyte impairment. Surprisingly, selective mineralocorticoid receptor (MR) antagonist eplerenone dramatically ameliorated the salt-induced proteinuria and renal injury in SHR/cps. Although salt loading reduced circulating aldosterone, it increased nuclear MR and expression of aldosterone effector kinase Sgk1 in the kidney. Gene expressions of transforming growth factor-beta 1 and plasminogen activator inhibitor-1 were also enhanced in the kidneys of salt-loaded SHR/cps, and eplerenone completely inhibited these injury markers. To clarify the discrepancy between decreased aldosterone and enhanced MR signaling by salt, we further investigated the role of oxidative stress, a putative key factor mediating salt-induced tissue damage. Interestingly, antioxidant Tempol attenuated the salt-evoked MR upregulation and Sgk1 induction and alleviated proteinuria and renal histological abnormalities, suggesting the involvement of oxidative stress in salt-induced MR activation. MR activation by salt was not attributed to increased serum corticosterone or reduced 11 beta-hydroxysteroid dehydrogenase type 2 activity. In conclusion, sodium loading exacerbated proteinuria and renal injury in metabolic syndrome rats. Salt reduced circulating aldosterone but caused renal MR activation at least partially via induction of oxidative stress, and eplerenone effectively improved the nephropathy.
C1 Univ Tokyo, Grad Sch Med, Dept Nephrol & Endocrinol, Bunkyo Ku, Tokyo 1138655, Japan.
   Univ Tokyo, Grad Sch Med, Dept Clin & Mol Epidemiol, 22nd Century Med & Res Ctr, Tokyo 1138655, Japan.
C3 University of Tokyo; University of Tokyo
RP Nagase, M (corresponding author), Univ Tokyo, Grad Sch Med, Dept Nephrol & Endocrinol, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1138655, Japan.
EM mnagase-tky@umin.ac.jp
OI Shibata, Shigeru/0000-0002-6868-0626
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NR 33
TC 143
Z9 147
U1 0
U2 8
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0194-911X
J9 HYPERTENSION
JI Hypertension
PD NOV
PY 2007
VL 50
IS 5
BP 877
EP 883
DI 10.1161/HYPERTENSIONAHA.107.091058
PG 7
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 225LA
UT WOS:000250518200013
PM 17875821
OA Bronze
DA 2025-06-11
ER

PT J
AU Abu-Zaid, A
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   Saleh, SAK
   Adly, HM
   Alomar, O
AF Abu-Zaid, Ahmed
   Bukhari, Ibtihal Abdulaziz
   Alyousef, Abdullah
   Baradwan, Saeed
   Bin Muaythir, Naif
   Almudaymigh, Yasir
   Abuzaid, Mohammed
   Saleh, Saleh A. K.
   Adly, Heba M.
   Alomar, Osama
TI Effect of selenium supplementation on cardiometabolic risk factors in
   polycystic ovary syndrome (PCOS) patients: A systematic review and
   meta-analysis of randomized clinical trials
SO PHARMANUTRITION
LA English
DT Review
DE Selenium; PCOS; Cardiometabolic; Systematic review; Meta-analysis
ID OXIDATIVE STRESS; WEIGHT-LOSS; WOMEN; INFLAMMATION; EXPRESSION;
   BIOMARKERS; MARKERS
AB Background: Polycystic ovary syndrome (PCOS) has been shown to be associated with cardiometabolic risk factors. Selenium (Se) is a naturally occurring mineral trace element that constitutes an essential component of selenoproteins and plays a vital role in antioxidant defense. This systematic review and meta-analysis aims to assess the effects of selenium supplementation on cardiometabolic risk factors in patients with PCOS.Methods: MEDLINE, Cochrane Central Register of Controlled Trials, Web of Science, and Scopus databases were searched up to March 2023 for randomized clinical trials that evaluated the effect of oral selenium supple-mentation on patients with PCOS. We employed a random-effects model to generate pooled estimates and 95% confidence intervals (CI).Results: Seven trials published between 2015 and 2022 were included. All the included studies were double blind, placebo-controlled trials. Selenium supplementation resulted in a significant decrease in VLDL (SMD =-0.35, 95% CI:-0.65;-0.05), MDA (SMD =-0.89, 95% CI:-1.21;-0.57) and hs-CRP (SMD =-0.38, 95% CI:-0.73;-0.03), as well as a significant increase in QUICKI (SMD = 0.78, 95% CI: 0.47; 1.09). The current meta-analysis did not find any significant changes in FPG, insulin, HOMA-IR, TC, TG, HDL, LDL, TAC, GSH, NO, SHBG, total testosterone, or mFG score for PCOS patients following selenium supplementation compared to placebo.Conclusion: Selenium supplementation may serve as a good adjunct therapy in patients with PCOS to decrease lipid peroxidation and inflammatory status. Moreover, selenium may improve insulin sensitivity in these pa-tients. However, the overall effects of selenium on all cardiometabolic risk factors in PCOS patients still need to be evaluated through large population and long duration RCTs.
C1 [Abu-Zaid, Ahmed] Alfaisal Univ, Coll Med, Riyadh, Saudi Arabia.
   [Bukhari, Ibtihal Abdulaziz] Princess Nourah Bint Abdulrahman Univ, Coll Med, Dept Obstet & Gynecol, Riyadh, Saudi Arabia.
   [Alyousef, Abdullah] Almaarefa Univ, Coll Med, Riyadh, Saudi Arabia.
   [Baradwan, Saeed] King Faisal Specialist Hosp & Res Ctr, Dept Obstet & Gynecol, Jeddah, Saudi Arabia.
   [Bin Muaythir, Naif; Almudaymigh, Yasir; Alomar, Osama] King Faisal Specialist Hosp & Res Ctr, Dept Obstet & Gynecol, Riyadh, Saudi Arabia.
   [Abuzaid, Mohammed] Muhayil Gen Hosp, Dept Obstet & Gynecol, Muhayil, Saudi Arabia.
   [Saleh, Saleh A. K.] Umm Al Qura Univ, Fac Med, Dept Biochem, Mecca, Saudi Arabia.
   [Saleh, Saleh A. K.] Ain Shams Univ, Fac Med, Oncol Diagnost Unit, Cairo, Egypt.
   [Adly, Heba M.] Umm Al Qura Univ, Fac Med, Dept Community Med & Pilgrims Healthcare, Mecca, Saudi Arabia.
C3 Alfaisal University; Princess Nourah bint Abdulrahman University;
   Almaarefa University; King Faisal Specialist Hospital & Research Center;
   King Faisal Specialist Hospital & Research Center; Umm Al-Qura
   University; Egyptian Knowledge Bank (EKB); Ain Shams University; Umm
   Al-Qura University
RP Abu-Zaid, A (corresponding author), Alfaisal Univ, Coll Med, Riyadh, Saudi Arabia.
EM aabuzaid@live.com
RI Saleh, Saleh/S-6837-2019; Azzam, Ahmed/ITT-4117-2023; Baradwan,
   Saeed/I-3387-2019; bukhari, ibtihal/JQJ-5131-2023; Adly, Prof
   Heba/IQU-8083-2023
OI Alomar, Osama/0000-0003-4715-9396; Adly, Prof Heba/0000-0002-9222-9149;
   Baradwan, Saeed/0000-0003-0427-8758; Saleh, Saleh
   Ahmed/0000-0001-9522-9198
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NR 60
TC 1
Z9 1
U1 4
U2 8
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2213-4344
J9 PHARMANUTRITION
JI PharmaNutrition
PD DEC
PY 2023
VL 26
AR 100358
DI 10.1016/j.phanu.2023.100358
EA SEP 2023
PG 11
WC Chemistry, Medicinal; Geriatrics & Gerontology; Gerontology; Nutrition &
   Dietetics; Pharmacology & Pharmacy
WE Emerging Sources Citation Index (ESCI)
SC Pharmacology & Pharmacy; Geriatrics & Gerontology; Nutrition & Dietetics
GA T9PQ4
UT WOS:001081235000001
DA 2025-06-11
ER

PT J
AU Dandona, P
   Aljada, A
   Chaudhuri, A
   Mohanty, P
   Garg, R
AF Dandona, P
   Aljada, A
   Chaudhuri, A
   Mohanty, P
   Garg, R
TI Metabolic syndrome - A comprehensive perspective based on interactions
   between obesity, diabetes, and inflammation
SO CIRCULATION
LA English
DT Article
ID FACTOR-KAPPA-B; NITRIC-OXIDE SYNTHASE; NECROSIS-FACTOR-ALPHA; C-REACTIVE
   PROTEIN; SPECIES ROS GENERATION; MONONUCLEAR-CELLS MNC; PLASMA TISSUE
   FACTOR; INSULIN-RESISTANCE; ASYMMETRIC DIMETHYLARGININE; OXIDATIVE
   STRESS
C1 SUNY Buffalo, Diabet Endocrinol Ctr Western New York, Div Endocrinol Diabet & Metab, Buffalo, NY 14209 USA.
   Kaleida Hlth, Buffalo, NY USA.
C3 State University of New York (SUNY) System; University at Buffalo, SUNY;
   Kaleida Health
RP SUNY Buffalo, Diabet Endocrinol Ctr Western New York, Div Endocrinol Diabet & Metab, 3 Gates Circle, Buffalo, NY 14209 USA.
EM pdandona@kaleidahealth.org
RI Aljada, Ahmad/KYQ-4122-2024
OI Garg, Rajesh/0000-0002-7779-1619; Aljada, Ahmad/0000-0001-8337-5454
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NR 76
TC 1017
Z9 1181
U1 3
U2 110
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0009-7322
EI 1524-4539
J9 CIRCULATION
JI Circulation
PD MAR 22
PY 2005
VL 111
IS 11
BP 1448
EP 1454
DI 10.1161/01.CIR.0000158483.13093.9D
PG 7
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 908RB
UT WOS:000227805700014
PM 15781756
OA Bronze
DA 2025-06-11
ER

PT J
AU Vancampfort, D
   Correll, CU
   Wampers, M
   Sienaert, P
   Mitchell, AJ
   De Herdt, A
   Probst, M
   Scheewe, TW
   De Hert, M
AF Vancampfort, D.
   Correll, C. U.
   Wampers, M.
   Sienaert, P.
   Mitchell, A. J.
   De Herdt, A.
   Probst, M.
   Scheewe, T. W.
   De Hert, M.
TI Metabolic syndrome and metabolic abnormalities in patients with major
   depressive disorder: a meta-analysis of prevalences and moderating
   variables
SO PSYCHOLOGICAL MEDICINE
LA English
DT Review
DE Depression; dislipidemia; hyperglycemia; metabolic syndrome; obesity
ID CORONARY-HEART-DISEASE; CARDIOVASCULAR EVENTS; PHYSICAL ILLNESS;
   RISK-FACTORS; ANTIDEPRESSANTS; MORTALITY; RECOMMENDATIONS;
   SCHIZOPHRENIA; GLUCOSE; HEALTH
AB Background. Individuals with depression have an elevated risk of cardiovascular disease (CVD) and metabolic syndrome (MetS) is an important risk factor for CVD. We aimed to clarify the prevalence and correlates of MetS in persons with robustly defined major depressive disorder (MDD).
   Method. We searched Medline, PsycINFO, EMBASE and CINAHL up until June 2013 for studies reporting MetS prevalences in individuals with MDD. Medical subject headings 'metabolic' OR 'diabetes' or 'cardiovascular' or 'blood pressure' or 'glucose' or 'lipid' AND 'depression' OR 'depressive' were used in the title, abstract or index term fields. Manual searches were conducted using reference lists from identified articles.
   Results. The initial electronic database search resulted in 91 valid hits. From candidate publications following exclusions, our search generated 18 studies with interview-defined depression (n= 5531, 38.9% male, mean age= 45.5 years). The overall proportion with MetS was 30.5% [95% confidence interval (CI) 26.3-35.1] using any standardized MetS criteria. Compared with age-and gender-matched control groups, individuals with MDD had a higher MetS prevalence [odds ratio (OR) 1.54, 95% CI 1.21-1.97, p= 0.001]. They also had a higher risk for hyperglycemia (OR 1.33, 95% CI 1.03-1.73, p= 0.03) and hypertriglyceridemia (OR 1.17, 95% CI 1.04-1.30, p= 0.008). Antipsychotic use (p<0.05) significantly explained higher MetS prevalence estimates in MDD. Differences in MetS prevalences were not moderated by age, gender, geographical area, smoking, antidepressant use, presence of psychiatric co-morbidity, and median year of data collection.
   Conclusions. The present findings strongly indicate that persons with MDD are a high-risk group for MetS and related cardiovascular morbidity and mortality. MetS risk may be highest in those prescribed antipsychotics.
C1 [Vancampfort, D.; Wampers, M.; Sienaert, P.; Probst, M.; De Hert, M.] Univ Psychiat Ctr KU Leuven, B-3070 Kortenberg, Belgium.
   [Vancampfort, D.; De Herdt, A.; Probst, M.] Katholieke Univ Leuven, Dept Rehabil Sci, Leuven, Belgium.
   [Correll, C. U.] Zucker Hillside Hosp, Glen Oaks, NY USA.
   [Correll, C. U.] Albert Einstein Coll Med, Bronx, NY 10467 USA.
   [Mitchell, A. J.] Leicestershire Partnership Trust, Dept Psychooncol, Leicester, Leics, England.
   [Mitchell, A. J.] Univ Leicester, Dept Canc & Mol Med, Leicester LE1 7RH, Leics, England.
   [Scheewe, T. W.] Windesheim Univ Appl Sci, Zwolle, Netherlands.
C3 KU Leuven; KU Leuven; Northwell Health; Yeshiva University; Montefiore
   Medical Center; Albert Einstein College of Medicine; University of
   Leicester
RP Vancampfort, D (corresponding author), Univ Psychiat Ctr KU Leuven, Campus Kortenberg,Leuvensesteenweg 517, B-3070 Kortenberg, Belgium.
EM davy.vancampfort@uc-kortenberg.be
RI De Hert, Marc/AAH-6090-2021; Vancampfort, Davy/AAD-1987-2019; Correll,
   Christoph/D-3530-2011; sienaert, pascal/HTP-4217-2023; Probst,
   Michel/ABE-6137-2020; Mitchell, Alex/A-3090-2009; Mitchell,
   Alex/P-5671-2015
OI Mitchell, Alex/0000-0001-6014-598X; De Hert, Marc/0000-0003-4255-5920;
   Sienaert, Pascal/0000-0002-0650-415X
FU BMS; Feinstein Institute for Medical Research; Janssen/JJ; NIMH;
   National Alliance for Research in Schizophrenia and Depression (NARSAD);
   AstraZeneca; Lundbeck JA; Janssen-Cilag; European Diabetes
   Foundation/Lilly; Otsuka; Pfizer; Sanofi-Aventis; Bristol-Myers Squibb;
   Takeda
FX C. U. Correll has been a consultant and/or advisor to or has received
   honoraria from: Actelion, Alexza, American Academy of Child and
   Adolescent Psychiatry, AstraZeneca, Biotis, Bristol-Myers Squibb,
   Cephalon, Desitin, Eli Lilly, GersonLehrman Group, GSK, IntraCellular
   Therapies, Lundbeck, Medavante, Medscape, Merck, National Institute of
   Mental Health (NIMH), Novartis, Ortho-McNeill/Janssen/J&J, Otsuka,
   Pfizer, ProPhase, Sunovion, Takeda, and Teva. He has received grant
   support from BMS, Feinstein Institute for Medical Research, Janssen/J&J,
   NIMH, National Alliance for Research in Schizophrenia and Depression
   (NARSAD), and Otsuka. P. Sienaert has been on the speakers/advisory
   boards of AstraZeneca, Lundbeck JA, Janssen-Cilag, Eli Lilly, Servier,
   Glaxo-Smith-Kline, and Bristol-Myers Squibb. A. De Herdt reports no
   financial relationships with commercial interests. M. De Hert has been a
   consultant for, received grant/research support and honoraria from, and
   has been on the speakers/advisory boards of: AstraZeneca, Lundbeck JA,
   Janssen-Cilag, European Diabetes Foundation/Lilly, Otsuka, Pfizer,
   Sanofi-Aventis, Bristol-Myers Squibb, and Takeda.
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NR 69
TC 242
Z9 258
U1 0
U2 34
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0033-2917
EI 1469-8978
J9 PSYCHOL MED
JI Psychol. Med.
PD JUL
PY 2014
VL 44
IS 10
BP 2017
EP 2028
DI 10.1017/S0033291713002778
PG 12
WC Psychology, Clinical; Psychiatry; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA AJ5UP
UT WOS:000337755100001
PM 24262678
DA 2025-06-11
ER

PT J
AU Wu, JL
   Wu, GH
   Li, JW
   Yi, B
   Jia, QY
   Ju, K
   Shi, QY
   Wang, ZX
   Xiao, X
   Guo, B
   Xu, H
   Zhao, X
AF Wu, Jialong
   Wu, Gonghua
   Li, Jiawei
   Yi, Bo
   Jia, Qingyi
   Ju, Ke
   Shi, Qingyang
   Wang, Zixuan
   Xiao, Xiong
   Guo, Bing
   Xu, Huan
   Zhao, Xing
TI Proteomic variation underlies the heterogeneous risk of metabolic
   dysfunction-associated steatotic liver disease for subsequent chronic
   diseases
SO EUROPEAN JOURNAL OF ENDOCRINOLOGY
LA English
DT Article
DE proteome; metabolic dysfunction-associated steatotic liver disease;
   chronic disease; mediation analysis
ID ADRENOMEDULLIN; VALIDATION; MECHANISMS; FSTL3
AB Background Metabolic dysfunction-associated steatotic liver disease (MASLD) is a heterogeneous condition. Whether and how the plasma proteome underlies the heterogeneous associations between MASLD and subsequent health outcomes remain unclear.Methods This study included 42 508 participants from the UK Biobank. Steatosis was defined by the fatty liver index. Individuals' MASLD-related proteomic signature was derived from 2911 plasma proteins. Cox models were used to assess the associations of the proteomic signature with 8 chronic diseases: liver fibrosis, cardiovascular disease (CVD), chronic kidney disease (CKD), chronic respiratory disease (CRD), dementia, depression, anxiety, and cancers. Adjusted survival curves were fitted to compare the cumulative incidence rate of diseases across quantiles of the proteomic signature; we further adjusted for the steatosis degree and cardiometabolic factors to test whether the association was independent of them. Mediation analyses were performed to identify mediating proteins.Results The proteomic signature was significantly associated with liver fibrosis, CVD, CKD, CRD, and depression in the MASLD population, with adjusted hazard ratios ranging from 1.30 to 4.94. Survival curves showed that individuals with the highest proteomic signature had the highest risk for these 5 diseases. These risk differences by signature persisted after adjustment for steatosis degree and cardiometabolic factors, except for depression. Proteins including ADM, ASGR1, and FABP4 were identified as common mediators of the association between MASLD and multiple diseases. Mediators of liver fibrosis showed specificity, with CDHR2 being the key protein.Conclusions Metabolic dysfunction-associated steatotic liver disease patients with the same steatosis severity but different proteomic responses may have different risks for future outcomes. Several key proteins may contribute to the progression of MASLD-related diseases.
   Metabolic dysfunction-associated steatotic liver disease (MASLD) and its proteomic signature were prospectively associated with liver fibrosis, cardiovascular disease, chronic kidney disease, chronic respiratory disease, depression, anxiety, and cancers. Metabolic dysfunction-associated steatotic liver disease patients with the same severity of steatotic liver but different proteomic signatures may have different risks for future health outcomes, and such differences were independent of cardiometabolic risk factors. Several plasma proteins, including ADM, ASGR1, and FABP4, were identified as common mediators of the association between MASLD and multiple chronic diseases. Mediators of liver fibrosis showed greater specificity, with CDHR2 being the key protein.
C1 [Wu, Jialong; Wu, Gonghua; Li, Jiawei; Yi, Bo; Xiao, Xiong; Guo, Bing; Xu, Huan; Zhao, Xing] Sichuan Univ, West China Sch Publ Hlth, 16,Sect 3,Renmin South Rd, Chengdu 610041, Sichuan, Peoples R China.
   [Wu, Jialong; Wu, Gonghua; Li, Jiawei; Yi, Bo; Xiao, Xiong; Guo, Bing; Xu, Huan; Zhao, Xing] Sichuan Univ, West China Hosp 4, 16,Sect 3,Renmin South Rd, Chengdu 610041, Sichuan, Peoples R China.
   [Jia, Qingyi] Sichuan Univ, West China Hosp, Dept Endocrinol & Metab, Chengdu 610041, Sichuan, Peoples R China.
   [Ju, Ke] Monash Univ, Sch Publ Hlth & Prevent Med, Melbourne, VIC 3004, Australia.
   [Shi, Qingyang] Univ Groningen, Groningen Res Inst Pharm, Fac Sci & Engn, NL-9747 AG Groningen, Netherlands.
   [Wang, Zixuan] Sichuan Ctr Dis Control & Prevent, Dept Informat, Chengdu 610041, Sichuan, Peoples R China.
C3 Sichuan University; Sichuan University; Sichuan University; Monash
   University; University of Groningen
RP Xu, H; Zhao, X (corresponding author), Sichuan Univ, West China Sch Publ Hlth, 16,Sect 3,Renmin South Rd, Chengdu 610041, Sichuan, Peoples R China.; Xu, H; Zhao, X (corresponding author), Sichuan Univ, West China Hosp 4, 16,Sect 3,Renmin South Rd, Chengdu 610041, Sichuan, Peoples R China.
EM xuhuan0514@foxmail.com; xingzhao@scu.edu.cn
FU National Science and Technology [117185]
FX This research was conducted under UKB application 117185.
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NR 61
TC 0
Z9 0
U1 0
U2 0
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0804-4643
EI 1479-683X
J9 EUR J ENDOCRINOL
JI Eur. J. Endocrinol.
PD MAY
PY 2025
VL 192
IS 5
BP 691
EP 703
DI 10.1093/ejendo/lvaf103
PG 13
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 3EB8R
UT WOS:001498140000001
PM 40378187
DA 2025-06-11
ER

PT J
AU Sjögren, P
   Basta, G
   de Caterina, R
   Rosell, M
   Basu, S
   Silveira, A
   de Faire, U
   Vessby, B
   Hamsten, A
   Hellenius, ML
   Fisher, RM
AF Sjogren, Per
   Basta, Giuseppina
   de Caterina, Raffaele
   Rosell, Magdalena
   Basu, Samar
   Silveira, Angela
   de Faire, Ulf
   Vessby, Bengt
   Hamsten, Anders
   Hellenius, Mai-Lis
   Fisher, Rachel M.
TI Markers of endothelial activity are related to components of the
   metabolic syndrome, but not to circulating concentrations of the
   advanced glycation end-product Nε-carboxymethyl-lysine in healthy
   Swedish men
SO ATHEROSCLEROSIS
LA English
DT Article
DE Endothelium; Adhesion molecules; Diet; AGE; Metabolic syndrome;
   Cardiovascular disease
ID LOW-DENSITY-LIPOPROTEIN; IMPAIRED RENAL-FUNCTION; C-REACTIVE PROTEIN;
   INSULIN-RESISTANCE; DIABETES-MELLITUS; FATTY-ACIDS; DAIRY FAT;
   DYSFUNCTION; INFLAMMATION; ASSOCIATIONS
AB Endothelial function is considered important in the development of cardiovascular diseases and type 2 diabetes. Circulating advanced glycation end-products (AGEs) and dietary components have been shown to affect endothelial function in type 2 diabetics, but determinants of endothelial function in a non-diabetic population are more poorly investigated. Therefore, we investigated relationships between dietary habits, AGEs and endothelial activation in men with isolated metabolic disturbances.
   Circulating markers of endothelial activation (soluble forms of vascular cell adhesion molecule-1, intercellular adhesion molecule-1, E-selectin and von Willebrand factor) and plasma N epsilon-carboxymethyl-lysine (CML, the predominant AGE in human plasma) were analyzed in a cross-sectional study of 294 healthy men. Individuals completed a 7-day dietary record, and metabolic and inflammatory parameters were determined. NCEP/ATPIII-criteria were used to define the metabolic syndrome.
   Endothelial activation was higher in individuals with the metabolic syndrome, and was positively related to certain features of the syndrome (insulin, glucose, inflammation and obesity), but not to others (triacylglycerol and blood pressure). Dietary factors were related to endothelial activation, but CML was not. Multivariate analysis revealed energy and alcohol intake, along with insulin and markers of oxidative stress and inflammation, to be positive predictors of endothelial activation.
   In this cohort of otherwise healthy men, endothelial activation was increased in individuals with the full metabolic syndrome, but not in those with only some of the components of the metabolic syndrome. Insulin resistance, inflammation, oxidative stress, the dietary intake of energy and alcohol, but not plasma CML, predicted endothelial activation in these men. (c) 2007 Elsevier Ireland Ltd. All rights reserved.
C1 [Sjogren, Per; Silveira, Angela; Hamsten, Anders; Fisher, Rachel M.] Karolinska Hosp, Dept Med, Atherosclerosis Res Unit, Stockholm, Sweden.
   [Basta, Giuseppina; de Caterina, Raffaele] CNR, Inst Clin Physiol, Pisa, Italy.
   [Rosell, Magdalena; de Faire, Ulf] Karolinska Inst, Inst Environm Med, Div Cardiovasc Epidemiol, Stockholm, Sweden.
   [Basu, Samar; Vessby, Bengt] Uppsala Univ, Dept Publ Hlth & Caring Sci, Uppsala, Sweden.
   [Hellenius, Mai-Lis] Karolinska Inst, Ctr Family & Community Med, Stockholm, Sweden.
C3 Karolinska Institutet; Karolinska University Hospital; Consiglio
   Nazionale delle Ricerche (CNR); Istituto di Fisiologia Clinica
   (IFC-CNR); Karolinska Institutet; Uppsala University; Karolinska
   Institutet
RP Fisher, RM (corresponding author), Karolinska Hosp, Dept Med, Atherosclerosis Res Unit, Stockholm, Sweden.
EM rachel.fisher@ki.se
RI Sjogren, Per/N-5923-2014; Fisher, Rachel/LRB-9254-2024; De Caterina,
   Raffaele/K-3857-2016; Basta, Giuseppina/B-8077-2015
OI Silveira, Angela/0000-0003-2063-4935; Fisher,
   Rachel/0000-0002-6031-5288; Sjogren, Per/0000-0003-1824-3193; Basta,
   Giuseppina/0000-0003-0809-4374
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NR 54
TC 12
Z9 14
U1 1
U2 5
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0021-9150
EI 1879-1484
J9 ATHEROSCLEROSIS
JI Atherosclerosis
PD DEC
PY 2007
VL 195
IS 2
BP E168
EP E175
DI 10.1016/j.atherosclerosis.2007.06.003
PG 8
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 244BC
UT WOS:000251840000030
PM 17655851
DA 2025-06-11
ER

PT J
AU Garcia-Silva, J
   Borrego, IRS
   Navarrete, NN
   Peralta-Ramirez, MI
   Aguila, FJ
   Caballo, VE
AF Garcia-Silva, Jaqueline
   Sanchez Borrego, Ismael Ramon
   Navarrete Navarrete, Nuria
   Isabel Peralta-Ramirez, Maria
   Jaen Aguila, Fernando
   Caballo, Vicente E.
TI Efficacy of cognitive-behavioural therapy for lifestyle modification in
   metabolic syndrome: a randomised controlled trial with a 18-months
   follow-up
SO PSYCHOLOGY & HEALTH
LA English
DT Article
DE Metabolic syndrome; cardiovascular risk factors; psychosocial factors;
   behavioural medicine; chronic diseases
ID MEDITERRANEAN DIET; PERCEIVED STRESS; SPANISH VERSION; HEALTH SURVEY;
   INTERVENTION; DEPRESSION; RISK; METAANALYSIS; INDIVIDUALS; ADHERENCE
AB Objective To test the efficacy of cognitive-behavioural therapy (CBT) for lifestyle modification in patients with metabolic syndrome (MetS). Design 76 MetS patients completed this clinical trial, with 18 months follow-up. 45 participants from the experimental group (EG - CBT) and 31 to the control group (CG - usual care). The CBT programme was performed by a psychologist in a face-to-face group format, during 12 weekly sessions lasting 90 minutes. The intervention for the CG consisted of workshops with basic information about MetS and it's associated cardiovascular risk. Main Outcome Measures Efficacy of (CBT) in (MetS) patients. Results Results showed reduction in weight (mean difference - MD -2.633, 95%CI [-4.322, -0.943]; p<.003), waist circumference (MD -2.944, 95%CI [-5.090, -0.798]; p<.008), body mass index (MD -0.915, 95%CI [-1.494, -0.335]; p<.003), systolic (MD -0.046, 95%CI [-0.685, -0.023]; p<.0002) diastolic blood pressure (MD -4.777, 95%CI [-7.750, -1.804]; p<.002), and cardiovascular risk score after 18 months. An increase in adherence to the Mediterranean diet and assertiveness and a reduction in anger were observed in EG. The CG did not show any significant differences. Conclusion The CBT focused on changes in lifestyle seems to be effective in the reduction of MetS and cardiovascular risk factors.
C1 [Garcia-Silva, Jaqueline; Isabel Peralta-Ramirez, Maria; Caballo, Vicente E.] Univ Granada, Sch Psychol, Dept Personal Assessment & Psychol Treatment, Granada, Spain.
   [Sanchez Borrego, Ismael Ramon] Univ Granada, Fac Sci, Dept Stat & Operat Res, Granada, Spain.
   [Navarrete Navarrete, Nuria] Univ Hosp Complex Granada, Clin Management Unit, Dept Internal Med, Granada, Spain.
   [Isabel Peralta-Ramirez, Maria; Caballo, Vicente E.] Univ Granada, CIMCYC Ctr Mind Brain & Behav Res, Granada, Spain.
   [Jaen Aguila, Fernando] Univ Hosp Complex Granada, Hypertens & Vasc Risk Unit, Dept Internal Med, Granada, Spain.
C3 University of Granada; University of Granada; University of Granada
RP Peralta-Ramirez, MI (corresponding author), Univ Granada, Dept Personalidad Evaluac & Tratamiento Psicol, Campus Cartuja S-N, Granada 18071, Spain.
EM Marialsabelmperalta@ugr.es
RI XAVIER SENRA, Luciana/U-2621-2018; Peralta-Ramirez, Maria
   Isabel/I-3920-2015; Caballo, Vicente/I-2891-2015
OI Peralta-Ramirez, Maria Isabel/0000-0001-8201-8906; Caballo,
   Vicente/0000-0002-2767-8028
FU Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior -CAPES
   [5566/10-0]
FX This work was supported by the [Coordenacao de Aperfeicoamento de
   Pessoal de Nivel Superior -CAPES], [Grant Number 5566/10-0].
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NR 67
TC 6
Z9 7
U1 1
U2 13
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0887-0446
EI 1476-8321
J9 PSYCHOL HEALTH
JI Psychol. Health
PD FEB 1
PY 2024
VL 39
IS 2
BP 195
EP 215
DI 10.1080/08870446.2022.2055023
EA MAR 2022
PG 21
WC Public, Environmental & Occupational Health; Psychology,
   Multidisciplinary
WE Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; Psychology
GA DE9W8
UT WOS:000774742900001
PM 35345950
DA 2025-06-11
ER

PT J
AU Hernández-Salinas, R
   Decap, V
   Leguina, A
   Cáceres, P
   Perez, D
   Urquiaga, I
   Iturriaga, R
   Velarde, V
AF Hernandez-Salinas, Romina
   Decap, Valerie
   Leguina, Alberto
   Caceres, Patricio
   Perez, Druso
   Urquiaga, Ines
   Iturriaga, Rodrigo
   Velarde, Victoria
TI Antioxidant and anti hyperglycemic role of wine grape powder in rats fed
   with a high fructose diet
SO BIOLOGICAL RESEARCH
LA English
DT Article
DE Insulin resistance; Oxidative stress; Metabolic syndrome; Wine grape
   powder
ID TRANSCRIPTION FACTOR NRF2; OXIDATIVE STRESS; METABOLIC SYNDROME;
   INSULIN-RESISTANCE; BLOOD-PRESSURE; RECEPTOR; CHOLESTEROL; INHIBITION;
   INDUCTION; PHASE-2
AB Background: Metabolic syndrome is a growing worldwide health problem. We evaluated the effects of wine grape powder (WGP), rich in antioxidants and fiber, in a rat model of metabolic syndrome induced by a high fructose diet. We tested whether WGP supplementation may prevent glucose intolerance and decrease oxidative stress in rats fed with a high fructose diet.
   Methods: Male Sprague-Dawley rats weighing 180 g were divided into four groups according to their feeding protocols. Rats were fed with control diet (C), control plus 20 % WGP (C + WGP), 50 % high fructose (HF) or 50 % fructose plus 20 % WGP (HF + WGP) for 16 weeks. Blood glucose, insulin and triglycerides, weight, and arterial blood pressure were measured. Homeostasis model assessment (HOMA) index was calculated using insulin and glucose values. A glucose tolerance test was performed 2 days before the end of the experiment. As an index of oxidative stress, thiobarbituric acid reactive substances (TBARS) level was measured in plasma and kidney, and superoxide dismutase was measured in the kidney.
   Results: Thiobarbituric acid reactive substances in plasma and renal tissue were significantly higher when compared to the control group. In addition, the area under the curve of the glucose tolerance test was higher in HF fed animals. Furthermore, fasting blood glucose, plasma insulin levels, and the HOMA index, were also increased. WGP supplementation prevented these alterations in rats fed with the HF diet. We did not find any significant difference in body weight or systolic blood pressure in any of the groups.
   Conclusions: Our results show that WGP supplementation prevented hyperglycemia, insulin resistance and reduced oxidative stress in rats fed with HF diet. We propose that WGP may be used as a supplement in human food as well.
C1 [Hernandez-Salinas, Romina; Decap, Valerie; Leguina, Alberto; Caceres, Patricio; Iturriaga, Rodrigo; Velarde, Victoria] Pontificia Univ Catolica Chile, Fac Ciencias Biol, Dept Fisiol, Alameda 340, Santiago, Chile.
   [Perez, Druso; Urquiaga, Ines; Iturriaga, Rodrigo; Velarde, Victoria] Pontificia Univ Catolica Chile, Ctr Mol Nutr & Chron Dis, Santiago, Chile.
C3 Pontificia Universidad Catolica de Chile; Pontificia Universidad
   Catolica de Chile
RP Velarde, V (corresponding author), Pontificia Univ Catolica Chile, Fac Ciencias Biol, Dept Fisiol, Alameda 340, Santiago, Chile.
EM vvelarde@bio.puc.cl
RI Iturriaga, Rodrigo/AAG-1020-2020; Leguina-Ruzzi, Alberto/K-5805-2017
OI Leguina-Ruzzi, Alberto/0000-0002-4761-3491; Iturriaga,
   Rodrigo/0000-0001-5387-9897; Velarde, Victoria/0000-0002-4465-831X
FU CONICYT, Chile [Fondef AF 10i1014]; project Puente, PUC [20/2013]
FX This work was supported by project Fondef AF 10i1014 from CONICYT, Chile
   and project Puente #20/2013, PUC.
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NR 44
TC 14
Z9 15
U1 0
U2 17
PU SOC BIOLGIA CHILE
PI SANTIAGO
PA CASILLA 16164, SANTIAGO 9, CHILE
SN 0716-9760
EI 0717-6287
J9 BIOL RES
JI Biol. Res.
PD SEP 30
PY 2015
VL 48
AR 53
DI 10.1186/s40659-015-0045-4
PG 9
WC Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics
GA CS7KC
UT WOS:000362261500001
PM 26420015
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Powell, LH
   Appelhans, BM
   Ventrelle, J
   Karavolos, K
   March, ML
   Ong, JC
   Fitzpatrick, SL
   Normand, P
   Dawar, R
   Kazlauskaite, R
AF Powell, Lynda H.
   Appelhans, Bradley M.
   Ventrelle, Jennifer
   Karavolos, Kelly
   March, Michelle L.
   Ong, Jason C.
   Fitzpatrick, Stephanie L.
   Normand, Patricia
   Dawar, Rebecca
   Kazlauskaite, Rasa
TI Development of a Lifestyle Intervention for the Metabolic Syndrome:
   Discovery Through Proof-of-Concept
SO HEALTH PSYCHOLOGY
LA English
DT Article
DE metabolic syndrome; lifestyle; intervention development;
   proof-of-concept; ORBIT model
ID PHYSICAL-ACTIVITY; INTRINSIC MOTIVATION; MEDITERRANEAN DIET;
   SELF-DETERMINATION; UNITED-STATES; OBESITY; STRESS; FOOD; MANAGEMENT;
   REDUCTION
AB Objective: The aim was to describe the early phases of the progressive development of a lifestyle treatment for sustained remission of the metabolic syndrome (MetS) using the Obesity-Related Behavioral Intervention Trials (ORBIT) model for behavioral treatment development as a guide. Methods: Early discovery and design phases produced a 3-component (diet, physical activity, stress), group-based lifestyle treatment with an intensive 6-month phase followed by monthly, participant-led maintenance meetings. In the proof-of-concept phase, 26 participants with the MetS (age 53 +/- 7 years, 77% female, and 65% ethnic minority) were recruited in a quasi-experimental design to determine if treatment could achieve the prespecified benchmark of MetS remission in >= 50% at 2.5 years. Exploratory outcomes focused on MetS components, weight, and patient-centered benefits on energy/vitality and psychosocial status. Results: MetS remission was achieved in 53.8% after a median of 2.5 years. At 2.5 years, an increase of + 15.4% reported eating >= 3 servings of vegetables/day, + 7.7% engaged in >= 150 minutes of moderate-to-vigorous physical activity/week; and + 11.5% reported experiencing no depression in the past 2 weeks. Weight loss >= 5% was achieved by 38.5%, and energy/vitality, negative affect, and social support improved. Median group attendance over 2.5 years was 73.8%. Conclusions: It is plausible that this lifestyle program can produce a remission in the MetS, sustained through 2.5 years. After refinements to enhance precision and strength, progression to feasibility pilot testing and a randomized clinical trial will determine its efficacy as a cost-effective lifestyle option for managing the MetS in the current health care system.
C1 [Powell, Lynda H.; Appelhans, Bradley M.] Rush Univ, Med Ctr, Dept Prevent Med, Dept Behav Sci, Chicago, IL 60612 USA.
   [Ventrelle, Jennifer; Karavolos, Kelly; March, Michelle L.; Normand, Patricia; Dawar, Rebecca] Rush Univ, Med Ctr, Dept Prevent Med, 1700 West Van Buren St,Suite 470, Chicago, IL 60612 USA.
   [Ong, Jason C.] Northwestern Univ, Dept Neurol, Ctr Circadian & Sleep Med, Feinberg Sch Med, Evanston, IL 60208 USA.
   [Fitzpatrick, Stephanie L.] Kaiser Permanente Ctr Hlth Res, Portland, OR USA.
   [Normand, Patricia] Rush Univ, Med Ctr, Dept Psychiat, Chicago, IL 60612 USA.
   [Kazlauskaite, Rasa] Rush Univ, Dept Med, Med Ctr, Chicago, IL 60612 USA.
C3 Rush University; Rush University; Northwestern University; Feinberg
   School of Medicine; Kaiser Permanente; Rush University; Rush University
RP Powell, LH (corresponding author), Rush Univ, Med Ctr, Dept Prevent Med, 1700 West Van Buren St,Suite 470, Chicago, IL 60612 USA.
EM lpowell@rush.edu
RI Kazlauskaite, Rasa/K-7224-2018
OI Fitzpatrick, Stephanie/0000-0003-2740-5502; March,
   Michelle/0000-0001-7553-4371; Ventrelle, Jennifer/0009-0009-3544-0712;
   Ong, Jason/0000-0002-7571-6738
FU William G. McGowan Charitable Fund; National Heart, Lung, and Blood
   Institute [P50HL105189, R56HL118343]
FX This work was supported by the William G. McGowan Charitable Fund and
   P50HL105189, R56HL118343 from the National Heart, Lung, and Blood
   Institute.
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NR 67
TC 10
Z9 13
U1 0
U2 13
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 0278-6133
EI 1930-7810
J9 HEALTH PSYCHOL
JI Health Psychol.
PD OCT
PY 2018
VL 37
IS 10
BP 929
EP 939
DI 10.1037/hea0000665
PG 11
WC Psychology, Clinical; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology
GA GU2IS
UT WOS:000445093400005
PM 30234352
OA hybrid, Green Accepted
DA 2025-06-11
ER

PT J
AU Alemzadeh, R
   Ellis, J
   Calhoun, M
   Kichler, J
AF Alemzadeh, Ramin
   Ellis, James
   Calhoun, Mariaelena
   Kichler, Jessica
TI Predictors of metabolic control at one year in a population of pediatric
   patients with type 2 diabetes mellitus: A retrospective study
SO JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
LA English
DT Article
DE type 2 diabetes mellitus; obesity; metabolic syndrome; syndrome X;
   metformin; adolescence; adherence
ID GLYCEMIC CONTROL; INSULIN THERAPY; CHILDREN; ADOLESCENTS; METFORMIN;
   DEPRESSION; CHILDHOOD; EPIDEMIC; OBESITY
AB Background/Objectives: The rising prevalence of pediatric type 2 diabetes mellitus (DM2) and non-adherence to diabetes regimens pose challenges to obtaining optimal control. This study evaluated factors that may impact glycemic control (HbA(1c)): age, Tanner stage, body mass index (BMI), total daily insulin (TDD), metformin dose (MET), activity level, frequency of clinic visits and adherence.
   Methods: One-year data from 72 patients (ages 8.6-17.8 years) were collected retrospectively. From that sample, 57 patients who continued to attend clinic for the entire year were assessed and divided into optimal and suboptimal HbA(1c) control groups.
   Results: All factors measured were similar in the two groups, except for lower initial and 1.0-year HbA(1c), TDD, and rates of missing MET and insulin in the optimal HbA(1c) control group.
   Conclusions: Initial glycemic status and adherence rate predicted metabolic control at one year. Early identification of DM2 may improve metabolic outcome, which may improve medical regimen adherence.
C1 Med Coll Wisconsin, Dept Pediat, Sect Pediat Endocrinol & Metab, Milwaukee, WI 53226 USA.
   Childrens Hosp Wisconsin, Ctr Diabet, Milwaukee, WI USA.
C3 Medical College of Wisconsin; Children's Hospital of Wisconsin
RP Alemzadeh, R (corresponding author), Med Coll Wisconsin, Dept Pediat, Sect Pediat Endocrinol & Metab, 8701 Watertown Plank Rd, Milwaukee, WI 53226 USA.
EM ralemzad@mcw.edu
RI Ellis, James/L-7985-2013
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NR 35
TC 2
Z9 3
U1 0
U2 4
PU WALTER DE GRUYTER GMBH
PI BERLIN
PA GENTHINER STRASSE 13, D-10785 BERLIN, GERMANY
SN 0334-018X
EI 2191-0251
J9 J PEDIATR ENDOCR MET
JI J. Pediatr. Endocrinol. Metab.
PD SEP
PY 2006
VL 19
IS 9
BP 1141
EP 1149
PG 9
WC Endocrinology & Metabolism; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Pediatrics
GA 105AU
UT WOS:000242002500007
PM 17128562
DA 2025-06-11
ER

PT J
AU Zhang, CY
   Jia, YZ
   Liu, B
   Wang, GL
   Zhang, Y
AF Zhang, Chaoyang
   Jia, Yinzhao
   Liu, Bo
   Wang, Guoliang
   Zhang, Yong
TI TLR4 knockout upregulates the expression of Mfn2 and PGC-1? in a high
   -fat diet and ischemia-reperfusion mice model of liver injury
SO LIFE SCIENCES
LA English
DT Article
ID TOLL-LIKE RECEPTORS; NONALCOHOLIC STEATOHEPATITIS; MITOCHONDRIAL
   DYSFUNCTION; METABOLIC SYNDROME; OXIDATIVE STRESS; STEATOTIC LIVER;
   DISEASE; PATHOGENESIS; FISSION; IMPACT
C1 [Zhang, Chaoyang; Jia, Yinzhao; Wang, Guoliang; Zhang, Yong] Huazhong Univ Sci & Technol, Tongji Med Coll, Union Hosp, Dept Hepatobiliary Surg, Wuhan, Peoples R China.
   [Liu, Bo] Wenzhou Med Univ, State Key Lab Ophthalmol Optometry & Vis Sci, Wenzhou, Peoples R China.
C3 Huazhong University of Science & Technology; Wenzhou Medical University
RP Zhang, Y (corresponding author), Huazhong Univ Sci & Technol, Tongji Med Coll, Union Hosp, Dept Hepatobiliary Surg, Wuhan, Peoples R China.
EM zhangyongtjmc@126.com
RI JIA, YINZHAO/HSG-9085-2023
FU National Natural Science Foundation of China [8157041114]; Wuhan Youth
   Science and Technology Talent Morning Light Program [2016070204010122]
FX This study was supported by the National Natural Science Foundation of
   China (no. 8157041114) and the Wuhan Youth Science and Technology Talent
   Morning Light Program (no. 2016070204010122).
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NR 57
TC 9
Z9 9
U1 0
U2 27
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0024-3205
EI 1879-0631
J9 LIFE SCI
JI Life Sci.
PD AUG 1
PY 2020
VL 254
AR 117762
DI 10.1016/j.lfs.2020.117762
PG 9
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA LZ8SC
UT WOS:000541489500014
PM 32437795
DA 2025-06-11
ER

PT J
AU Sasanfar, B
   Emrani, AS
   Zademohammadi, F
   Forootani, B
   Emamgholipour, S
   Jambarsang, S
   Khayyatzadeh, SS
   Pourrajab, F
   Ardakani, SAY
   Esmaillzadeh, A
   Salehi-Abarghouei, A
AF Sasanfar, Bahareh
   Emrani, Arezoo sadat
   Zademohammadi, Faezeh
   Forootani, Bita
   Emamgholipour, Solaleh
   Jambarsang, Sara
   Khayyatzadeh, Sayyed Saeid
   Pourrajab, Fatemeh
   Yasini Ardakani, Seyed Ali
   Esmaillzadeh, Ahmad
   Salehi-Abarghouei, Amin
TI The impact of a blend of Pistacia atlantica seed and
   canola oil compared with a blend of corn-canola oil with synthetic
   antioxidant and corn-canola oil without synthetic antioxidant on
   oxidative stress markers in patients with metabolic syndrome: protocol
   for a triple-blind, randomized, three-way cross-over clinical trial
SO TRIALS
LA English
DT Article
DE Pistacia atlantica oil; Corn oil; TBHQ; Metabolic syndrome; Antioxidant;
   Oxidative stress
ID TERT-BUTYLHYDROQUINONE
AB Background Metabolic syndrome (MetS) is regarded as a complex metabolic disorder. Recently, the role of dietary antioxidants in the underlying pathogenesis and complications of MetS has come into focus. Pistacia atlantica oil is known as a high antioxidant oil which might improve the antioxidant status of dietary oils and also oxidative stress markers. On the other hand, tert-Butylhydroquinone (TBHQ) is an approved food-grade synthetic antioxidant that acts both as an inducer and inhibitor of carcinogenesis. The current trial will explore the possible effect of a blend of Pistacia atlantica seed-canola oils, corn-canola oils with TBHQ, and corn-canola oil without TBHQ on oxidative stress markers in patients with MetS.Methods We will conduct a single-center, triple-blind, three-way randomized cross-over clinical trial (RCT) among 72 patients with MetS. After a 1-month run-in period, eligible participants will consume the intervention oils as their regularly consumed oils in a random order. Each intervention period will last 8 weeks separated by 4-week washout periods. Anthropometric indices, body composition, physical activity, blood pressure, and 24-h dietary food recall measurements will be assessed at the beginning and the end of each intervention period. The primary outcome will be oxidative stress markers including serum total antioxidant capacity, total oxidant status, malondialdehyde, nitric oxide, and the enzyme activity of myeloperoxidase, superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase. The secondary outcomes will be changes in MetS components including blood pressure, fasting blood glucose, triglyceride, high-density lipoprotein cholesterol, and anthropometric measurements.Discussion Pistacia atlantica seed oil is high in antioxidants. An intervention with this oil could offer an option for oxidative stress prevention among patients with metabolic syndrome. The present clinical trial will be the first one assessing the impact of Pistacia atlantica oil on human oxidative stress markers.
C1 [Sasanfar, Bahareh; Emrani, Arezoo sadat; Zademohammadi, Faezeh; Forootani, Bita; Khayyatzadeh, Sayyed Saeid; Salehi-Abarghouei, Amin] Shahid Sadoughi Univ Med Sci, Res Ctr Food Hyg & Safety, Sch Publ Hlth, Yazd, Iran.
   [Sasanfar, Bahareh; Emrani, Arezoo sadat; Zademohammadi, Faezeh; Forootani, Bita; Khayyatzadeh, Sayyed Saeid; Salehi-Abarghouei, Amin] Shahid Sadoughi Univ Med Sci, Sch Publ Hlth, Dept Nutr, Yazd, Iran.
   [Sasanfar, Bahareh] Univ Tehran Med Sci, Canc Inst Iran, Canc Res Ctr, Tehran, Iran.
   [Emamgholipour, Solaleh] Univ Tehran Med Sci, Sch Med, Dept Clin Biochem, Tehran, Iran.
   [Jambarsang, Sara] Shahid Sadoughi Univ Med Sci, Sch Publ Hlth, Dept Biostat & Epidemiol, Yazd, Iran.
   [Pourrajab, Fatemeh] Shahid Sadoughi Univ Med Sci, Sch Med, Dept Biochem & Mol Biol, Yazd, Iran.
   [Yasini Ardakani, Seyed Ali] Islamic Azad Univ, Res Ctr food & Confectionary, Yazd Branch, Yazd, Iran.
   [Esmaillzadeh, Ahmad] Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Community Nutr, POB 14155-6117, Tehran, Iran.
   [Esmaillzadeh, Ahmad] Univ Tehran Med Sci, Endocrinol & Metab Mol Cellular Sci Inst, Obes & Eating Habits Res Ctr, Tehran, Iran.
   [Salehi-Abarghouei, Amin] Shahid Sadoughi Univ Med Sci, Noncommunicable Dis Res Inst, Yazd Cardiovasc Res Ctr, Yazd, Iran.
C3 Shahid Sadoughi University of Medical Sciences; Shahid Sadoughi
   University of Medical Sciences; Tehran University of Medical Sciences;
   Tehran University of Medical Sciences; Shahid Sadoughi University of
   Medical Sciences; Shahid Sadoughi University of Medical Sciences;
   Islamic Azad University; Tehran University of Medical Sciences; Tehran
   University of Medical Sciences; Shahid Sadoughi University of Medical
   Sciences
RP Salehi-Abarghouei, A (corresponding author), Shahid Sadoughi Univ Med Sci, Res Ctr Food Hyg & Safety, Sch Publ Hlth, Yazd, Iran.; Salehi-Abarghouei, A (corresponding author), Shahid Sadoughi Univ Med Sci, Sch Publ Hlth, Dept Nutr, Yazd, Iran.; Salehi-Abarghouei, A (corresponding author), Shahid Sadoughi Univ Med Sci, Noncommunicable Dis Res Inst, Yazd Cardiovasc Res Ctr, Yazd, Iran.
EM abargouei@ssu.ac.ir
RI Sasanfar, Bahareh/JXW-7984-2024; Pourrajab, Fatemeh/Q-8493-2017;
   Esmaillzadeh, Ahmad/N-5704-2014; Emamgholipour, Solaleh/T-6035-2017;
   Jambarsang, Sara/S-2637-2017
FU Shahid Sadoughi University of Medical Sciences; Neshatavar food industry
   (Datis Corporation)
FX The study was jointly funded by Shahid Sadoughi University of Medical
   Sciences (http:// www. ssu. ac. ir) and the Neshatavar food industry
   (Datis Corporation; http:// www. nesha tavar. com/?l= EN). The
   investigators did not have a direct financial relationship with Datis
   Corporation and Shahid Sadoughi University of Medical Sciences received
   the funds and delivered them to the investigators. Datis Corporation
   also provided all of the intervention oils used during the study
   including a blend of Pistacia atlantica seed and canola oils,
   corn-canola oil with TBHQ, corn-canola oil without TBHQ, and sunflower
   oils
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NR 36
TC 0
Z9 0
U1 0
U2 7
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1745-6215
J9 TRIALS
JI Trials
PD JUL 24
PY 2023
VL 24
IS 1
AR 473
DI 10.1186/s13063-023-07269-1
PG 10
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA N5HY6
UT WOS:001037332900001
PM 37488571
OA gold
DA 2025-06-11
ER

PT J
AU Violanti, JM
   Ma, CC
   Gu, JK
   Fekedulegn, D
   Mnatsakanova, A
   Andrew, ME
AF Violanti, John M.
   Ma, Claudia C.
   Gu, Ja K.
   Fekedulegn, Desta
   Mnatsakanova, Anna
   Andrew, Michael E.
TI Social avoidance in policing: Associations with cardiovascular disease
   and the role of social support
SO POLICING-AN INTERNATIONAL JOURNAL OF POLICE STRATEGIES & MANAGEMENT
LA English
DT Article
DE Social support; Police culture; Cardiovascular disease; Metabolic
   syndrome; Social avoidance
ID CORONARY-ARTERY-DISEASE; MEDLEY HOSTILITY SCALE; METABOLIC SYNDROME;
   RISK-FACTORS; STRESS; REACTIVITY; HEART; DEPRESSION; MORTALITY; SYMPTOMS
AB Purpose The purpose of this paper is to examine the association of social avoidance among police, cardiovascular disease (CVD) (metabolic syndrome (MetSyn)), and social support.
   Design/methodology/approach Participants were officers from the Buffalo Cardio-Metabolic Occupational Police Stress study (n=289). Social avoidance (defined as the tendency to avoid social contact) and other subscales from the Cook-Medley Hostility Scale were analyzed. The mean number of MetSyn components across tertiles of the Cook-Medley scales was computed using analysis of variance and analysis of covariance. Social support was measured with the Social Provisions Scale, categorized as high or low based on the median.
   Findings The mean number of MetSyn components increased significantly across tertiles of social avoidance (1.510.18, 1.520.12, and 1.810.12); the only Cook-Medley subscale that remained significantly associated with MetSyn following adjustment for age and gender. Participants high in social avoidance reported significantly lower social support (79.9 +/- 8.5 vs 85.8 +/- 8.6; p=0.001).
   Research limitations/implications The study is cross-sectional and therefore precludes causality. The authors were unable to determine the direction of associations between social avoidance and MetSyn. The measure of social support was unidimensional, including only perceived support; additional types of social support measures would be helpful.
   Practical implications This study suggests that occupational-based police social isolation is associated with health outcomes and lower support. Several suggestions are made which will help to improve communication between the police and public. Examples are the use of social media, training in communication techniques, and changing the police role to one of public guardians.
   Originality/value Social avoidance is the least studied the Cook-Medley subscale associated with CVD. It is important for the health of officers to maintain a social connection with others.
C1 [Violanti, John M.] SUNY Buffalo, Sch Publ Hlth & Hlth Profess, Dept Epidemiol & Environm Hlth, Buffalo, NY 14260 USA.
   [Ma, Claudia C.; Gu, Ja K.; Fekedulegn, Desta; Mnatsakanova, Anna; Andrew, Michael E.] NIOSH, Biostat & Epidemiol Branch, Ctr Dis Control & Prevent, Hlth Effects Lab Div, Morgantown, WV USA.
C3 State University of New York (SUNY) System; University at Buffalo, SUNY;
   Centers for Disease Control & Prevention - USA; National Institute for
   Occupational Safety & Health (NIOSH)
RP Violanti, JM (corresponding author), SUNY Buffalo, Sch Publ Hlth & Hlth Profess, Dept Epidemiol & Environm Hlth, Buffalo, NY 14260 USA.
EM violanti@buffalo.edu; iia4@cdc.gov; gum4@cdc.gov; djf7@cdc.gov;
   fma8@cdc.gov; mta6@cdc.gov
OI Ma, Claudia C./0000-0001-5639-5978; /0000-0002-0245-5899
CR [Anonymous], PERL SECR STAT HOM D
   [Anonymous], 2015, FINAL REPORT PRESIDE
   [Anonymous], FBI LAW ENFORCEMENT
   [Anonymous], FOOD FREQ QUEST
   [Anonymous], J LAW ENFORCEMENT LE
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NR 53
TC 9
Z9 14
U1 0
U2 6
PU EMERALD GROUP PUBLISHING LTD
PI Leeds
PA Floor 5, Northspring 21-23 Wellington Street, Leeds, W YORKSHIRE,
   ENGLAND
SN 1363-951X
EI 1758-695X
J9 POLICING
JI Policing-An Int J Police Strategies & Manag.
PY 2018
VL 41
IS 5
BP 539
EP 549
DI 10.1108/PIJPSM-02-2017-0017
PG 11
WC Criminology & Penology
WE Social Science Citation Index (SSCI)
SC Criminology & Penology
GA GP8DF
UT WOS:000441139500002
PM 31049018
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Olechnowicz, J
   Tinkov, A
   Skalny, A
   Suliburska, J
AF Olechnowicz, J.
   Tinkov, A.
   Skalny, A.
   Suliburska, Joanna
TI Zinc status is associated with inflammation, oxidative stress, lipid,
   and glucose metabolism
SO JOURNAL OF PHYSIOLOGICAL SCIENCES
LA English
DT Review
DE Oxidative stress; Inflammation; Zinc; Lipid metabolism; Glucose
   metabolism
ID SUBCUTANEOUS ADIPOSE-TISSUE; PANCREATIC BETA-CELLS; INSULIN-RESISTANCE;
   GENE-EXPRESSION; ADIPOCYTE DIFFERENTIATION; OXIDE NANOPARTICLES;
   NUTRITIONAL-STATUS; DIABETES-MELLITUS; ENZYME-ACTIVITY; DOUBLE-BLIND
AB A number of studies have reported that zinc plays a substantial role in the development of metabolic syndrome, taking part in the regulation of cytokine expression, suppressing inflammation, and is also required to activate antioxidant enzymes that scavenge reactive oxygen species, reducing oxidative stress. Zinc also plays a role in the correct functioning of lipid and glucose metabolism, regulating and forming the expression of insulin. In numerous studies, zinc supplementation has been found to improve blood pressure, glucose, and LDL cholesterol serum level. Deeper knowledge of zinc's properties may help in treating metabolic syndrome, thus protecting against stroke and angina pectoris, and ultimately against death.
C1 [Olechnowicz, J.; Suliburska, Joanna] Poznan Univ Life Sci, Ul Wojska Polskiego 31, PL-62624 Poznan, Poland.
   [Tinkov, A.] Orenburg State Med Univ, Sovetskaya St,6, Orenburg 460000, Russia.
   [Tinkov, A.; Skalny, A.] Orenburg State Univ, Pobedy Ave,13, Orenburg 460018, Russia.
   [Tinkov, A.; Skalny, A.] RUDN Univ, Miklukho Maklay St,10-2, Moscow 117198, Russia.
   [Tinkov, A.; Skalny, A.] Yaroslavl State Univ, Sovetskaya St,14, Yaroslavl 150000, Russia.
   [Skalny, A.] All Russian Res Inst Med & Aromat Plants VILAR, Grina St,7, Moscow 117216, Russia.
C3 Poznan University of Life Sciences; Orenburg State University; Peoples
   Friendship University of Russia; Yaroslavl State University; All-Russian
   Research Institute of Medicinal & Aromatic Plants
RP Suliburska, J (corresponding author), Poznan Univ Life Sci, Ul Wojska Polskiego 31, PL-62624 Poznan, Poland.
EM jsulibur@up.poznan.pl
RI Skalny, Anatoly/J-3953-2019; Tinkov, Alexey/H-5842-2016; Skalny,
   Andrey/V-2641-2018
OI Suliburska, Joanna/0000-0002-0937-8427; Tinkov,
   Alexey/0000-0003-0348-6192; Skalny, Andrey/0000-0001-5310-3853
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NR 141
TC 396
Z9 421
U1 8
U2 108
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1880-6546
EI 1880-6562
J9 J PHYSIOL SCI
JI J. Physiol. Sci.
PD JAN
PY 2018
VL 68
IS 1
BP 19
EP 31
DI 10.1007/s12576-017-0571-7
PG 13
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA FS0SS
UT WOS:000419484600002
PM 28965330
OA Green Published, gold
HC Y
HP N
DA 2025-06-11
ER

PT S
AU Kiecolt-Glaser, JK
   Wilson, SJ
AF Kiecolt-Glaser, Janice K.
   Wilson, Stephanie J.
BE Widiger, T
   Cannon, TD
TI Lovesick: How Couples' Relationships Influence Health
SO ANNUAL REVIEW OF CLINICAL PSYCHOLOGY, VOL 13
SE Annual Review of Clinical Psychology
LA English
DT Article; Book Chapter
DE marriage; depression; convergence; interdependence; sleep; metabolism
ID ALL-CAUSE MORTALITY; LONGITUDINAL DYADIC ANALYSIS; SELF-RATED HEALTH;
   MIDDLE-AGED WOMEN; DEPRESSIVE SYMPTOMS; METABOLIC SYNDROME; MARITAL
   QUALITY; OLDER-ADULTS; MARRIED-COUPLES; CHRONIC STRESS
AB This review highlights recent advances in research addressing intimate partner relationships and health. Consideration of the strong mutual influences that the members of a couple have on each other's mental and physical health trajectories provides a new way to view the health implications of couples' convergence or interdependence; marital closeness can have a clear downside when one partner has mental or physical health problems. Couples' inter-connectedness can also be leveraged to promote better treatment outcomes. Major themes include the pivotal role of depression and the importance of gender differences in the pathways from the marital relationship to physiological functioning and health. The health risks and benefits of support are weighed. Additionally, two prominent emerging paths from marital distress to poor health are emphasized: sleep problems and metabolic alterations that promote obesity and its comorbidities.
C1 [Kiecolt-Glaser, Janice K.; Wilson, Stephanie J.] Ohio State Univ, Coll Med, Inst Behav Med Res, Columbus, OH 43210 USA.
   [Kiecolt-Glaser, Janice K.] Ohio State Univ, Coll Med, Dept Psychiat & Behav Hlth, Columbus, OH 43210 USA.
C3 University System of Ohio; Ohio State University; University System of
   Ohio; Ohio State University
RP Kiecolt-Glaser, JK (corresponding author), Ohio State Univ, Coll Med, Inst Behav Med Res, Columbus, OH 43210 USA.; Kiecolt-Glaser, JK (corresponding author), Ohio State Univ, Coll Med, Dept Psychiat & Behav Hlth, Columbus, OH 43210 USA.
EM Janice.Kiecolt-Glaser@osumc.edu; Stephanie.Wilson2@osumc.edu
RI Kiecolt-Glaser, Janice/A-3236-2009
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NR 147
TC 320
Z9 370
U1 15
U2 177
PU ANNUAL REVIEWS
PI PALO ALTO
PA 4139 EL CAMINO WAY, PO BOX 10139, PALO ALTO, CA 94303-0897 USA
SN 1548-5943
J9 ANNU REV CLIN PSYCHO
JI Annu. Rev. Clin. Psychol.
PY 2017
VL 13
BP 421
EP 443
DI 10.1146/annurev-clinpsy-032816-045111
PG 23
WC Psychology, Clinical; Psychology
WE Book Citation Index – Social Sciences & Humanities (BKCI-SSH); Book Citation Index – Science (BKCI-S); Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology
GA BH5PE
UT WOS:000401334300017
PM 28301763
OA Green Accepted
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Franik, G
   Krysta, K
   Witkowska, A
   Dudek, A
   Krzystanek, M
   Madej, P
AF Franik, Grzegorz
   Krysta, Krzysztof
   Witkowska, Agnieszka
   Dudek, Arkadiusz
   Krzystanek, Marek
   Madej, Pawel
TI The impact of sex hormones and metabolic markers on depressive symptoms
   and cognitive functioning in PCOS patients
SO GYNECOLOGICAL ENDOCRINOLOGY
LA English
DT Article
DE PCOS; metabolic syndrome; sex hormones; cognitive functions; memory;
   executive functions
ID POLYCYSTIC-OVARY-SYNDROME; INSULIN-RESISTANCE; SLEEP DISTURBANCES;
   WOMEN; TESTOSTERONE; ANXIETY; RISK; PREVALENCE; DIAGNOSIS; SAMPLE
AB The aim of the study was to analyze associations between cognitive deficits and such factors like hormone levels and metabolic risk factors in PCOS women. Fifty-five PCOS patients aged 17-30 underwent analyses for FSH, LH, 17-beta-estradiol, DHEAS, androstenedione, SHBG, lipid profile during the follicular phase. Fasting glucose and insulin concentrations were also measured, as well as their levels after oral-glucose administration. All participants underwent an assessment with: Trail Making Test A and B, Stroop Test, Verbal and Categorical Fluency Test. The intensity of depressive symptoms was measured by the Beck Depression Inventory (BDI). We observed a positive correlation of the depression scores with the OGTT 120 ' and triglycerides, and a negative correlation of the depression scores with serum HDL. The higher were the insulin levels at 120 min; the more pronounced were the deficits of the verbal psychomotor speed. Higher free testosterone correlated with better verbal psychomotor speed. Androstenedione level was associated with worse scores in executive functions assessment. 17-OH-P levels positively correlated with phonology verbal fluency scores and higher plasma cortisol level at 10 p.m. correlated with worse verbal processing speed. Endocrine and metabolic parameters seem to be important factors mediating cognitive deficits in PCOS.
C1 [Franik, Grzegorz; Madej, Pawel] Med Univ Silesia, Dept Endocrinol Gynecol, Ul Medykow 14, PL-40751 Katowice, Poland.
   [Krysta, Krzysztof; Krzystanek, Marek] Med Univ Silesia, Dept Rehabil Psychiat, Katowice, Poland.
   [Witkowska, Agnieszka] Med Univ Silesia, Dept Endocrinol Gynecol, Students Sci Soc, Katowice, Poland.
   [Dudek, Arkadiusz] Med Univ Silesia, Students Sci Soc, Dept Rehabil Psychiat, Katowice, Poland.
C3 Medical University of Silesia; Medical University of Silesia; Medical
   University of Silesia; Medical University of Silesia
RP Franik, G (corresponding author), Med Univ Silesia, Dept Endocrinol Gynecol, Ul Medykow 14, PL-40751 Katowice, Poland.
EM gfranik@sum.edu.pl
RI Krysta, Krzysztof/AAZ-6290-2020; Krzystanek, Marek/ABH-8341-2020
OI Krysta, Krzysztof/0000-0002-5984-3358; Franik,
   Grzegorz/0000-0003-0127-7258; Witkowska-Berek,
   Agnieszka/0000-0002-0504-4403; Krzystanek, Marek/0000-0002-1665-7344;
   Madej, Pawel/0000-0002-6447-1667
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NR 46
TC 8
Z9 8
U1 1
U2 29
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0951-3590
EI 1473-0766
J9 GYNECOL ENDOCRINOL
JI Gynecol. Endocrinol.
PD NOV 2
PY 2019
VL 35
IS 11
BP 965
EP 969
DI 10.1080/09513590.2019.1613359
EA MAY 2019
PG 5
WC Endocrinology & Metabolism; Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Obstetrics & Gynecology
GA JG6UG
UT WOS:000469527100001
PM 31106608
DA 2025-06-11
ER

PT J
AU Sage, AT
   Holtby-Ottenhof, S
   Shi, YY
   Damjanovic, S
   Sharma, AM
   Werstuck, GH
AF Sage, Andrew T.
   Holtby-Ottenhof, Sarah
   Shi, Yuanyuan
   Damjanovic, Suzana
   Sharma, Arya M.
   Werstuck, Geoff H.
TI Metabolic Syndrome and Acute Hyperglycemia Are Associated With
   Endoplasmic Reticulum Stress in Human Mononuclear Cells
SO OBESITY
LA English
DT Article
ID UNFOLDED PROTEIN RESPONSE; NF-KAPPA-B; ACCELERATED ATHEROSCLEROSIS;
   PATHWAYS; CHOLESTEROL; ACTIVATION; EXPRESSION; APOPTOSIS; DISEASE;
   GLUCOSE
AB Endoplasmic reticulum (ER) stress and the activation of the unfolded protein response (UPR) have been implicated in a number of complications associated with diabetes mellitus including micro-and macrovascular dysfunction. In this study we examine ER stress levels in blood cells isolated from human subjects with metabolic syndrome and in healthy controls. Total RNA and protein were isolated from leukocytes and the levels of specific ER stress markers were quantified by real-time-PCR and immunoblot analysis. Our results indicate that, compared to healthy controls, individuals with metabolic syndrome have elevated mRNA levels of genes indicative of ER stress; including spliced XBP-1 (sXBP-1), Grp78, and CHOP. Induced ER stress levels correlate with blood glucose but not plasma lipid concentration. Furthermore, in healthy individuals, a standard 75 g oral glucose challenge produced a significant elevation in spliced XBP-1 (1.3 fold), Grp78 (2.0 fold), and calreticulin (3.5 fold) mRNA 60 min post challenge and a significant increase in Grp78 (2.0 fold), calreticulin (2.7 fold) protein levels 2 h postchallenge, relative to fasting levels. The UPR was also activated ex vivo, in human leukocytes cultured in the presence of 15 mmol/ l glucose, supporting a specific role for glucose. The oral glucose challenge was associated with a significant increase in the expression of inflammatory cytokines, including interleukin (IL)-1 alpha/beta, IL-6, and IL-8, that may result from ER stress. These findings suggest that there is an association between both acute and chronic dysglycemia and ER stress in humans.
C1 [Sage, Andrew T.; Holtby-Ottenhof, Sarah; Shi, Yuanyuan; Werstuck, Geoff H.] Thrombosis & Atherosclerosis Res Inst, Hamilton, ON, Canada.
   [Sage, Andrew T.; Werstuck, Geoff H.] McMaster Univ, Dept Biochem & Biomed Sci, Hamilton, ON, Canada.
   [Damjanovic, Suzana; Sharma, Arya M.] Hamilton Hlth Sci, Hamilton, ON, Canada.
   [Werstuck, Geoff H.] McMaster Univ, Dept Med, Hamilton, ON, Canada.
C3 McMaster University; McMaster University; McMaster University; McMaster
   University
RP Werstuck, GH (corresponding author), Thrombosis & Atherosclerosis Res Inst, Hamilton, ON, Canada.
EM Geoff.Werstuck@taari.ca
RI Sage, Andrew/JKH-5873-2023
FU Canadian Institute of Health Research [MOP-62910]; Heart and Stroke
   Foundation [T-6104]
FX Funding from the Canadian Institute of Health Research (MOP-62910) and
   the Heart and Stroke Foundation (T-6104) has supported this work.
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NR 30
TC 52
Z9 56
U1 0
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1930-7381
EI 1930-739X
J9 OBESITY
JI Obesity
PD APR
PY 2012
VL 20
IS 4
BP 748
EP 755
DI 10.1038/oby.2011.144
PG 8
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 917AC
UT WOS:000302143300007
PM 21633399
OA Bronze
DA 2025-06-11
ER

PT J
AU Farag, MM
   Ashour, EH
   El-Hadidy, WF
AF Farag, Mahmoud M.
   Ashour, Ehab H.
   El-Hadidy, Wessam F.
TI Amelioration of High Fructose Diet-Induced Insulin Resistance,
   Hyperuricemia, and Liver Oxidative Stress by Combined Use of Selective
   Agonists of PPAR-α and PPAR-γ in Rats
SO DUBAI MEDICAL JOURNAL
LA English
DT Article
DE Fenofibrate; High fructose diet; Insulin resistance; Metabolic syndrome;
   Pioglitazone; Uric acid
ID PROLIFERATOR-ACTIVATED RECEPTOR; METABOLIC SYNDROME;
   SUPEROXIDE-DISMUTASE; URIC-ACID; CARDIOVASCULAR-DISEASE;
   LIPID-METABOLISM; FENOFIBRATE; EXPRESSION; OBESITY; INFLAMMATION
AB Background: The use of high-fructose (Fr) corn sweeteners and sucrose in manufactured food has markedly increased recently. This excessive Fr intake has been proposed in the etiology of the metabolic syndrome, which shows an increasing prevalence throughout the world. Objective: In this study, we questioned whether fenofibrate (FF), a peroxisome proliferator-activated receptor (PPAR)-alpha agonist, and pioglitazone (PG), a PPAR-gamma agonist, might be effective in ameliorating the metabolic syndrome in a rat model. Materials and Methods: The metabolic syndrome was induced by feeding rats a high-Fr (60%) diet for 10 weeks. The rats were divided into 5 groups: control group, fed a normal rat chow; Fr + vehicle group; Fr + FF group; Fr + PG group; and Fr + (FF + PG) group (treated with both drugs). Drug or vehicle treatment was given daily for 6 weeks (from weeks 5 to 10). Thereafter, blood and liver samples were obtained for biochemical studies. Results: Rats fed a high-Fr diet developed hyperglycemia, hyperinsulinemia, hyperuricemia, hypertriglyceridemia, and hypercholesterolemia, and had increased serum alanine aminotransferase, hepatic tumor necrosis factor-alpha, and malondialdehyde levels but decreases in both glutathione content and superoxide dismutase activity. Rat treatment with FF and/or PG attenuated these alterations. The improvement was greater with the combined treatment than with either drug alone, and normalization of insulin sensitivity was observed only in rats treated with the combination therapy. Conclusion: Acting on the 2 main PPAR subfamilies, the combination of FF and PG provides a more efficacious therapy for modulating the changes in serum insulin, uric acid, and lipids, as well as the accompanying hepatic inflammation and oxidative stress that characterize the Fr-induced metabolic syndrome.
C1 [Farag, Mahmoud M.; Ashour, Ehab H.; El-Hadidy, Wessam F.] Alexandria Univ, Med Res Inst, Dept Pharmacol, 165 El Horria Ave,PO El Hadara, Alexandria 21561, Egypt.
C3 Egyptian Knowledge Bank (EKB); Alexandria University
RP Farag, MM (corresponding author), Alexandria Univ, Med Res Inst, Dept Pharmacol, 165 El Horria Ave,PO El Hadara, Alexandria 21561, Egypt.
EM mahmoudfarag2012@hotmail.com
RI El-Hadidy, Wessam/ACV-9667-2022
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NR 59
TC 7
Z9 7
U1 0
U2 2
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
EI 2571-726X
J9 DUBAI MED J
JI Dubai Med. J.
PD AUG
PY 2020
VL 3
IS 2
BP 76
EP 86
DI 10.1159/000506899
PG 11
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA SD7YY
UT WOS:000651593400008
OA gold
DA 2025-06-11
ER

PT J
AU Filippov, MA
   Tatarnikova, OG
   Pozdnyakova, NV
   Vorobyov, VV
AF Filippov, Mikhail A.
   Tatarnikova, Olga G.
   Pozdnyakova, Natalia, V
   Vorobyov, Vasily V.
TI Inflammation/bioenergetics-associated neurodegenerative pathologies and
   concomitant diseases: a role of mitochondria targeted catalase and
   xanthophylls
SO NEURAL REGENERATION RESEARCH
LA English
DT Review
DE algae xanthophylls; Alzheimer's disease; atherosclerosis; depression;
   type 2 diabetes; metabolic syndrome; mitochondria-targeted catalase;
   noncommunicable chronic diseases; stress
ID DIET-INDUCED OBESITY; NERVE GROWTH-FACTOR; IMPROVES GLUCOSE-METABOLISM;
   AMYLOID PLAQUE DEPOSITION; DEPRESSIVE-LIKE BEHAVIOR;
   IRRITABLE-BOWEL-SYNDROME; TRANSGENIC MOUSE MODEL; FACTOR GENE-THERAPY;
   BODY-WEIGHT GAIN; OXIDATIVE STRESS
AB Various inflammatory stimuli are able to modify or even "re-program" the mitochondrial metabolism that results in generation of reactive oxygen species. In noncommunicable chronic diseases such as atherosclerosis and other cardiovascular pathologies, type 2 diabetes and metabolic syndrome, these modifications become systemic and are characterized by chronic inflammation and, in particular, "neuroinflammation" in the central nervous system. The processes associated with chronic inflammation are frequently grouped into "vicious circles" which are able to stimulate each other constantly amplifying the pathological events. These circles are evidently observed in Alzheimer's disease, atherosclerosis, type 2 diabetes, metabolic syndrome and, possibly, other associated pathologies. Furthermore, chronic inflammation in peripheral tissues is frequently concomitant to Alzheimer's disease. This is supposedly associated with some common genetic polymorphisms, for example, Apolipoprotein-E epsilon 4 allele carriers with Alzheimer's disease can also develop atherosclerosis. Notably, in the transgenic mice expressing the recombinant mitochondria targeted catalase, that removes hydrogen peroxide from mitochondria, demonstrates the significant pathology amelioration and health improvements. In addition, the beneficial effects of some natural products from the xanthophyll family, astaxanthin and fucoxanthin, which are able to target the reactive oxygen species at cellular or mitochondrial membranes, have been demonstrated in both animal and human studies. We propose that the normalization of mitochondrial functions could play a key role in the treatment of neurodegenerative disorders and other noncommunicable diseases associated with chronic inflammation in ageing. Furthermore, some prospective drugs based on mitochondria targeted catalase or xanthophylls could be used as an effective treatment of these pathologies, especially at early stages of their development.
C1 [Filippov, Mikhail A.; Tatarnikova, Olga G.; Pozdnyakova, Natalia, V] Sistema BioTech LLC, Moscow, Russia.
   [Vorobyov, Vasily V.] Russian Acad Sci, Inst Cell Biophys, Pushchino, Russia.
C3 Russian Academy of Sciences; Pushchino Scientific Center for Biological
   Research (PSCBI) of the Russian Academy of Sciences; Institute of Cell
   Biophysics RAS
RP Filippov, MA (corresponding author), Sistema BioTech LLC, Moscow, Russia.
EM mikhail.filippov@sistemabiotech.ru
RI Vorobyov, Vasily/C-7025-2015; Filippov, Mikhail/V-7475-2018
OI Filippov, Mikhail/0000-0003-4739-7482
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NR 226
TC 15
Z9 17
U1 5
U2 173
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, 400059, INDIA
SN 1673-5374
EI 1876-7958
J9 NEURAL REGEN RES
JI Neural Regen. Res.
PD FEB
PY 2021
VL 16
IS 2
BP 223
EP 233
AR PMID 32859768
DI 10.4103/1673-5374.290878
PG 11
WC Cell Biology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Neurosciences & Neurology
GA NU5DI
UT WOS:000573661500004
PM 32859768
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Ozan, G
   Bircan, FS
   Topal, T
   Türközkan, N
AF Ozan, Gonca
   Bircan, Filiz Sezen
   Topal, Turgut
   Turkozkan, Nurten
TI The effects of melatonin on brain nitrosative stress and energy balance
   in fructose-mediated metabolic syndrome model
SO TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
LA English
DT Article
DE Fructose; metabolic syndrome; melatonin; brain; energy
ID OXIDE SYNTHASE ACTIVITY; NITRIC-OXIDE; INDUCED HYPERTENSION; OXIDATIVE
   STRESS; RAT-BRAIN; IN-VIVO; EXPRESSION; DEFICIENCY; ACTIVATION
AB Objective: Metabolic syndrome (MetS), one of the common health problems seen with increasing frequency in today's modern societies, is also a important risk factor for neurological disorders such as stroke, depression, Alzheimer's disease. On the other hand, melatonin is a neurohormone, has potent antioxidant and neuroprotective activities. In the present study, we aimed to investigate the possible protective effects of melatonin administration on brain tissue in fructose-mediated MetS model.
   Methods: Male adult Sprague-Dawley rats were randomly divided into four groups (n=8); control, fructose, melatonin and fructose plus melatonin. MetS was induced by fructose solution 20% in tap water, and melatonin was administered at the dose of 20 mg/kg bw/day by oral gavage. Systolic blood pressures (SBP) were measured by tail-cuff method. After the experimental period of 8 weeks, serum triglyceride, glucose, insulin, and tissue ATP/ADP ratio, nitric oxide (NOx) and 3-nitrotyrosine (3-NT) levels were measured. Also tissue endothelial and inducible nitric oxide synthase (eNOS and iNOS) protein levels were determined.
   Results: Fructose consumption increased SBP, serum triglyceride, insulin levels and induced insulin resistance significantly compared to control group and MetS model was successfully demonstrated. In comparison with control group, fructose administration did not cause significant changes in tissue ATP/ADP ratio and 3-NT levels. NOx levels did not change significantly among groups, and iNOS-eNOS proteins were not detected in any groups. Interestingly, tissue 3-NT levels were elevated significantly while ATP/ADP ratio was diminished in fructose plus melatonin group compare with both control and fructose groups.
   Conclusion: These results indicate that high fructose diet for 8 weeks does not influence nitric oxide production, energy metabolism and protein nitration in brain. Nevertheless melatonin acted as a pro-oxidant at that dose when administered with fructose.
C1 [Ozan, Gonca] Firat Univ, Fac Vet Med, Dept Biochem, TR-23169 Elazig, Turkey.
   [Bircan, Filiz Sezen] Gazi Univ, Fac Sci, Dept Biol, Ankara, Turkey.
   [Topal, Turgut] Gulhane Mil Med Acad, Dept Physiol, Ankara, Turkey.
   [Turkozkan, Nurten] Gazi Univ, Fac Med, Dept Biochem, Ankara, Turkey.
C3 Firat University; Gazi University; Gulhane Military Medical Academy;
   Gazi University
RP Ozan, G (corresponding author), Firat Univ, Fac Vet Med, Dept Biochem, TR-23169 Elazig, Turkey.
EM gozan@firat.edu.tr
OI Bircan, Filiz Sezen/0000-0002-1007-2484
FU Gazi University, Department of Scientific Research Projects Unit
   [01/2010-17]
FX This study was supported by Gazi University, Department of Scientific
   Research Projects Unit (Project Number: 01/2010-17).
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NR 32
TC 0
Z9 0
U1 0
U2 7
PU WALTER DE GRUYTER GMBH
PI BERLIN
PA GENTHINER STRASSE 13, D-10785 BERLIN, GERMANY
SN 0250-4685
EI 1303-829X
J9 TURK J BIOCHEM
JI Turk. J. Biochem.
PD FEB
PY 2016
VL 41
IS 1
BP 37
EP 43
DI 10.1515/tjb-2016-0006
PG 7
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA DM3HT
UT WOS:000376238200006
OA gold
DA 2025-06-11
ER

PT J
AU Nikpayam, O
   Roshan, H
   Sohrab, G
   Sedaghat, M
AF Nikpayam, Omid
   Roshan, Hanieh
   Sohrab, Golbon
   Sedaghat, Meghdad
TI Effects of Green Coffee Extract Supplementation on Oxidative Stress,
   Systemic and Vascular Inflammation in Patients with Metabolic Syndrome:
   A Randomized Clinical Trial
SO IRANIAN RED CRESCENT MEDICAL JOURNAL
LA English
DT Article
DE Chlorogenic Acid; Inflammation; Metabolic Syndrome; Oxidative Stress
ID CHLOROGENIC ACID; IMPROVE; POLYPHENOLS; PROFILE
AB Background: Metabolic syndrome (Mets) is accompanied by oxidative stress and low-grade inflammation. Green coffee is rich in polyphenols called chlorogenic acids (CGA), which possess anti-inflammatory and anti-oxidative characteristics.
   Objectives: The aim of this study was to evaluate the effects of green coffee extract (GCE) on the oxidative stress as well as the systemic and vascular inflammation in patients having Mets.
   Methods: This randomized clinical trial was conducted in 2016 in Iran. Forty-three individuals (21 in the intervention and 22 in the control group) with Mets were randomly assigned to take 400 mg GCE supplements twice a day in the intervention group or placebo capsules in the control group for 8 - weeks. The serum levels of intercellular adhesion molecule-1 (ICAM-1), interleukin-6 (IL-6), high sensitivity C-reactive protein (hs-CRP), and malondialdehyde (MDA) were evaluated at the beginning and 8 - weeks after the intervention.
   Results: No significant discrepancy was observed regarding serum levels of IL-6, MDA, hs-CRP, and ICAM-1 between the intervention and control group at the beginning and the end of the trial. After eight weeks of intervention, the mean changes of IL6 in the treatment and the placebo group were respectively (-0.73 +/- 2.65 VS 1.70 +/- 10.51 Pg/mL, P value = 0.3), hs-CRP (-0.28 +/- 3.12 VS -0.08 +/- 4.15mg/L, P value = 0.86), MDA (0.44 +/- 1.68 VS 0.32 +/- 2.28 mu mol/L, P value = 0.84), and ICAM-1 (-0.05 +/- 0.45 VS 0.02 +/- 0.45 ng/mL, P value = 0.54).
   Conclusions: In this trial, the green coffee extract (GCE) administration did not affect oxidative stress, systemic, and vascular inflammation in subjects with metabolic syndrome.
C1 [Nikpayam, Omid; Roshan, Hanieh; Sohrab, Golbon] Shahid Beheshti Univ Med Sci, Fac Nutr Sci & Food Technol, Clin Nutr & Dietet Dept, POB 19395-4741,Hafezi St,Farahzadi Blv, Tehran, Iran.
   [Sedaghat, Meghdad] Shahid Beheshti Univ Med Sci, Imam Hossein Hosp, Tehran, Iran.
C3 Shahid Beheshti University Medical Sciences; Shahid Beheshti University
   Medical Sciences
RP Roshan, H; Sohrab, G (corresponding author), Shahid Beheshti Univ Med Sci, Fac Nutr Sci & Food Technol, Clin Nutr & Dietet Dept, POB 19395-4741,Hafezi St,Farahzadi Blv, Tehran, Iran.
EM h91.roshan@gmail.com; golbonsohrab@yahoo.com
RI Sohrab, Golbon/AHE-4922-2022; Nikpayam, Omid/AGG-5000-2022; sedaghat,
   meghdad/K-3289-2017; Roshan, Hanieh/G-1175-2017
OI sedaghat, meghdad/0000-0002-3966-0597; Roshan,
   Hanieh/0000-0003-1460-5265; nikpayam, omid/0000-0002-6301-1597
FU National Nutrition and Food Technology Research Institute of Iran
FX The National Nutrition and Food Technology Research Institute of Iran.
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NR 33
TC 9
Z9 9
U1 0
U2 5
PU Dubai Iranian Hosp
PI Dubai
PA Al Wasl Road , Jumeirah 1, P.O.BOX: 2330, Dubai, U ARAB EMIRATES
SN 2074-1804
EI 2074-1812
J9 IRAN RED CRESCENT ME
JI Iran. Red Crescent Med. J.
PD JUN
PY 2018
VL 20
IS 6
AR e67971
DI 10.5812/ircmj.67971
PG 10
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA GU9PZ
UT WOS:000445683300010
OA gold
DA 2025-06-11
ER

PT J
AU Colak, E
   Zoric, L
AF Colak, Emina
   Zoric, Lepsa
TI Interrelation of Oxidative Stress and Genetics in Pathophysiology of
   Obesity and Obesity-Related Conditions
SO GENES
LA English
DT Review
DE antioxidant enzymes; oxidative stress; obesity; SNPs; transcription
   factors
ID INSULIN-RESISTANCE; SERUM PARAOXONASE; PRO198LEU POLYMORPHISM;
   GLUTATHIONE-PEROXIDASE; ANTIOXIDANT DEFENSE; METABOLIC SYNDROME;
   DIABETES-MELLITUS; INCREASED RISK; GPX-1 GENE; ASSOCIATION
AB Obesity is a medical condition influenced by many factors and manifested by the excessive accumulation of fat. It is well documented that oxidative stress plays a significant role in the development of obesity and its related diseases. The antioxidant system's enzymes, such as catalase, superoxide dismutase, glutathione peroxidase, paroxonase, etc., play a significant role in maintaining the oxidant-antioxidant balance in living organisms. Genetic variants of antioxidant system genes may affect the antioxidant system and its efficacy, which can lead to increased oxidative stress and higher risk for the development of obesity and its comorbidities. This review is focused on genetic variants such as single nucleotide polymorphisms of some antioxidant enzymes, ROS generators and transcription factors, and their impact on increased oxidative stress and the development of obesity and medical conditions related to obesity, like insulin resistance and metabolic syndrome.
C1 [Colak, Emina] Univ Clin Ctr Serbia, Inst Med Biochem, Belgrade 11000, Serbia.
   [Zoric, Lepsa] Univ Clin Ctr Serbia, Clin Eye Dis, Belgrade 11000, Serbia.
   [Zoric, Lepsa] Univ Pristina Kosovska Mitrovica UPKM, Fac Med, Kosovska Mitrovica 40000, Serbia.
C3 Clinical Centre of Serbia; Clinical Centre of Serbia
RP Colak, E (corresponding author), Univ Clin Ctr Serbia, Inst Med Biochem, Belgrade 11000, Serbia.
EM emina.colak.bg@gmail.com; zoriclepsa@gmail.com
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NR 74
TC 0
Z9 0
U1 0
U2 0
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2073-4425
J9 GENES-BASEL
JI Genes
PD APR 25
PY 2025
VL 16
IS 5
AR 489
DI 10.3390/genes16050489
PG 12
WC Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Genetics & Heredity
GA 3AK8M
UT WOS:001495656000001
PM 40428311
DA 2025-06-11
ER

PT J
AU Kahl, KG
   Herrmann, J
   Stubbs, B
   Krüger, THC
   Cordes, J
   Deuschle, M
   Schweiger, U
   Hüper, K
   Helm, S
   Birkenstock, A
   Hartung, D
AF Kahl, K. G.
   Herrmann, J.
   Stubbs, B.
   Krueger, T. H. C.
   Cordes, J.
   Deuschle, M.
   Schweiger, U.
   Hueper, K.
   Helm, S.
   Birkenstock, A.
   Hartung, D.
TI Pericardial adipose tissue and the metabolic syndrome is increased in
   patients with chronic major depressive disorder compared to acute
   depression and controls
SO PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
LA English
DT Article
DE Chronic major depressive disorder; Cardio-vascular disorder; Pericardial
   adipose tissue; Body composition; Hypothalamus-pituitary-adrenal system
ID CORONARY-HEART-DISEASE; ADRENAL-GLAND VOLUME; EPICARDIAL FAT;
   PERSONALITY-DISORDERS; SALIVARY CORTISOL; RISK-FACTOR; LIFE-STYLE;
   METAANALYSIS; ASSOCIATION; EXERCISE
AB Objective: Major depressive disorder (MDD) is associated with an estimated fourfold risk for premature death, largely attributed to cardiovascular disorders. Pericardial adipose tissue (PAT), a fat compartment surrounding the heart, has been implicated in the development of coronary artery disease. An unanswered question is whether people with chronic MDD are more likely to have elevated PAT volumes versus acute MDD and controls (CTRL).
   Methods: The study group consists of sixteen patients with chronic MDD, thirty-four patients with acute MDD, and twenty-five CTRL. PAT and adrenal gland volume were measured by magnetic resonance tomography. Additional measures comprised factors of the metabolic syndrome, cortisol, relative insulin resistance, and pro-inflammatory cytokines (interleukin-6; IL-6 and tumor necrosis factor-alpha, TNF-alpha).
   Results: PAT volumes were significantly increased in patients with chronic MDD > patients with acute MDD > CTRL. Adrenal gland volume was slightly enlarged in patients with chronic MDD > acute MDD > CTRL, although this difference failed to reach significance. The PAT volume was correlated with adrenal gland volume, and cortisol concentrations were correlated with depression severity, measured by BDI-2 and MADRS. Group differences were found concerning the rate of the metabolic syndrome, being most frequent in chronic MDD > acute MDD > CTRL. Further findings comprised increased fasting cortisol, increased TNF-a concentration, and decreased physical activity level in MDD compared to CTRL.
   Conclusion: Our results extend the existing literature in demonstrating that patients with chronic MDD have the highest risk for developing cardiovascular disorders, indicated by the highest PAT volume and prevalence of metabolic syndrome. The correlation of PAT with adrenal gland volume underscores the role of the hypothalamus-pituitary-adrenal system as mediator for body-composition changes. Metabolic monitoring, health advices and motivation for the improvement of physical fitness may be recommended in depressed patients, in particular in chronic depression. (C) 2016 Elsevier Inc. All rights reserved.
C1 [Kahl, K. G.; Herrmann, J.; Krueger, T. H. C.; Helm, S.; Birkenstock, A.] Hannover Med Sch MHH, Dept Psychiat Social Psychiat & Psychotherapy, Hannover, Germany.
   [Hueper, K.; Hartung, D.] MHH, Inst Diagnost & Intervent Radiol, Hannover, Germany.
   [Cordes, J.] Univ Dusseldorf, Dept Psychiat & Psychotherapy, Dusseldorf, Germany.
   [Stubbs, B.] South London & Maudsley NHS Fdn Trust, Physiotherapy Dept, Denmark Hill, London SE5 8AZ, England.
   [Stubbs, B.] Kings Coll London, Inst Psychiat, Hlth Serv & Populat Res Dept, London, England.
   [Deuschle, M.] Cent Inst Mental Hlth, Mannheim, Germany.
   [Schweiger, U.] Univ Lubeck, Dept Psychiat & Psychotherapy, Lubeck, Germany.
C3 Hannover Medical School; Hannover Medical School; Heinrich Heine
   University Dusseldorf; University of London; King's College London;
   Central Institute of Mental Health; University of Lubeck
RP Kahl, KG (corresponding author), Hannover Med Sch, Dept Psychiat Social Psychiat & Psychotherapy, Carl Neuberg Str 1, D-30625 Hannover, Germany.
EM kahl.kai@mh-hannover.de
RI Stubbs, Brendon/X-1904-2018; Kruger, Tillmann/F-3493-2012; Stubbs,
   Brendon/C-5696-2015
OI Stubbs, Brendon/0000-0001-7387-3791
FU Servier
FX Financial disclosure: Kai G. Kahl received speaker honoraria from Eli
   Lilly, BMS, Otsuka, Servier, Lundbeck and Janssen-Cilag and a research
   grant from Servier.
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NR 81
TC 27
Z9 28
U1 2
U2 71
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0278-5846
EI 1878-4216
J9 PROG NEURO-PSYCHOPH
JI Prog. Neuro-Psychopharmacol. Biol. Psychiatry
PD JAN 4
PY 2017
VL 72
BP 30
EP 35
DI 10.1016/j.pnpbp.2016.08.005
PG 6
WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA DZ9WN
UT WOS:000386231900005
PM 27528109
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Pennathur, S
   Jaiswal, M
   Vivekanandan-Giri, A
   White, EA
   Ang, L
   Raffel, DM
   Rubenfire, M
   Pop-Busui, R
AF Pennathur, Subramaniam
   Jaiswal, Mamta
   Vivekanandan-Giri, Anuradha
   White, Elizabeth A.
   Ang, Lynn
   Raffel, David M.
   Rubenfire, Melvyn
   Pop-Busui, Rodica
TI Structured lifestyle intervention in patients with the metabolic
   syndrome mitigates oxidative stress but fails to improve measures of
   cardiovascular autonomic neuropathy
SO JOURNAL OF DIABETES AND ITS COMPLICATIONS
LA English
DT Article
DE Metabolic syndrome; Cardiovascular autonomic neuropathy; Oxidative
   stress; Lifestyle intervention; Mediterranean diet
ID HIGH-DENSITY-LIPOPROTEIN; NERVOUS-SYSTEM FUNCTION; BLOOD-FLOW
   REGULATION; MEDITERRANEAN DIET; DIABETIC-PATIENTS; ANTIOXIDANT CAPACITY;
   GLUCOSE-TOLERANCE; ASSOCIATION; DYSFUNCTION; PREVALENCE
AB Aims: To assess the role of oxidative stress in mediating adverse outcomes in metabolic syndrome (MetS) and resultant cardiovascular autonomic neuropathy (CAN), and to evaluate the effects of lifestyle interventions on measures of oxidative stress and CAN in subjects with MetS.
   Methods: Pilot study in 25 non-diabetic subjects with MetS (age 49 +/- 10 years, 76% females) participating in a 24-week lifestyle intervention (supervised aerobic exercise/Mediterranean diet), and 25 age-matched healthy controls. CAN was assessed by cardiovascular reflex tests, heart rate variability (HRV) and PET imaging with sympathetic analog [C-11] meta-hydroxyephedrine ([C-11]HED). Specific oxidative fingerprints were measured by liquid-chromatography/mass-spectrometry (LC/MS).
   Results: At baseline, MetS subjects had significantly higher oxidative stress markers [3-nitrotyrosine (234 +/- 158 vs. 54 +/- 47 mu mol/mol tyrosine), ortho-tyrosine (59 +/- 38 vs. 18 +/- 10 mu mol/molphenylalanine, all P < 0.0001], and impaired HRV at rest and during deep breathing (P = 0.039 and P = 0.021 respectively) compared to controls. Twenty-four-week lifestyle intervention significantly reduced all oxidative stress markers (all P < 0.01) but did not change any of the CAN measures.
   Conclusions: Subjects with MetS present with signs of CAN and increased oxidative stress in the absence of diabetes. The 24-week lifestyle intervention was effective in ameliorating oxidative stress, but did not improve measures of CAN. Larger clinical trials with longer duration are required to confirm these findings. (C) 2017 Elsevier Inc. All rights reserved.
C1 [Pennathur, Subramaniam] Univ Michigan, Dept Internal Med & Mol & Integrat Physiol, Div Nephrol, Ann Arbor, MI USA.
   [Jaiswal, Mamta] Univ Michigan, Dept Neurol, Ann Arbor, MI USA.
   [Vivekanandan-Giri, Anuradha; White, Elizabeth A.] Univ Michigan, Dept Internal Med, Ann Arbor, MI 48109 USA.
   [Ang, Lynn; Pop-Busui, Rodica] Univ Michigan, Dept Internal Med, Div Metab Endocrinol & Diabet, Ann Arbor, MI 48109 USA.
   [Raffel, David M.] Univ Michigan, Dept Radiol, Div Nucl Med, Ann Arbor, MI 48109 USA.
   [Rubenfire, Melvyn] Univ Michigan, Dept Internal Med, Div Cardiovasc Med, Ann Arbor, MI 48109 USA.
C3 University of Michigan System; University of Michigan; University of
   Michigan System; University of Michigan; University of Michigan System;
   University of Michigan; University of Michigan System; University of
   Michigan; University of Michigan System; University of Michigan;
   University of Michigan System; University of Michigan
RP Pop-Busui, R (corresponding author), 5329 Brehm Tower,1000 Wall St, Ann Arbor, MI 48109 USA.
EM rpbusui@umich.edu
RI Pennathur, Subramaniam/O-7032-2017
OI Pennathur, Subramaniam/0000-0003-3628-6883; Jaiswal,
   Mamta/0000-0003-1727-6225; Pop-Busui, Rodica/0000-0002-2042-1350
FU DK [DK082841]; National Institute of Diabetes and Digestive and Kidney
   Diseases [P30DK020572]; AMERICAN DIABETES [ASSOCIATION-1-08-CR-48,
   DK089503, DK097153, DK081943, R01HL102334-01]; National Institute of
   Diabetes and Digestive and Kidney Diseases [P30DK089503, P30DK020572,
   P30DK081943] Funding Source: NIH RePORTER
FX This work was supported in part by the following grants: AMERICAN
   DIABETES ASSOCIATION-1-08-CR-48 (RPB), R01HL102334-01 (RPB), DK089503,
   DK097153 DK081943 and DK DK082841 (SP). This study was also supported by
   Grant Number P30DK020572 (MDRC) from the National Institute of Diabetes
   and Digestive and Kidney Diseases.
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NR 55
TC 17
Z9 17
U1 0
U2 6
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1056-8727
EI 1873-460X
J9 J DIABETES COMPLICAT
JI J. Diabetes Complications
PD SEP
PY 2017
VL 31
IS 9
BP 1437
EP 1443
DI 10.1016/j.jdiacomp.2017.03.008
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA FD9WQ
UT WOS:000407873200012
PM 28709739
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Pate, T
   Anthony, DC
   Radford-Smith, DE
AF Pate, Trinity
   Anthony, Daniel C.
   Radford-Smith, Daniel E.
TI cFOS expression in the prefrontal cortex correlates with altered
   cerebral metabolism in developing germ-free mice
SO FRONTIERS IN MOLECULAR NEUROSCIENCE
LA English
DT Article
DE microbiota; cFOS; short-chain fatty acids (SCFAs); germ free animal;
   metabolomics; acetate; glutamate; glutamine
ID C-FOS; MESSENGER-RNA; IMMUNE-SYSTEM; MICROBIOTA; LIVER; MICROGLIA; GENE;
   DEPRESSION; BEHAVIORS; BARRIER
AB IntroductionThe microbiota plays a critical role in modulating various aspects of host physiology, particularly through the microbiota-gut-brain (MGB) axis. However, the mechanisms that transduce and affect gut-to-brain communication are still not well understood. Recent studies have demonstrated that dysbiosis of the microbiome is associated with anxiety and depressive symptoms, which are common complications of metabolic syndrome. Germ-free (GF) animal models offer a valuable tool for studying the causal effects of microbiota on the host. MethodsWe employed gene expression and nuclear magnetic resonance (NMR)-based metabolomic techniques to investigate the relationships between brain plasticity and immune gene expression, peripheral immunity, and cerebral and liver metabolism in GF and specific pathogen-free (SPF) mice. ResultsOur principal findings revealed that brain acetate (p = 0.012) was significantly reduced in GF relative to SPF mice, whereas glutamate (p = 0.0013), glutamine (p = 0.0006), and N-acetyl aspartate (p = 0.0046) metabolites were increased. Notably, cFOS mRNA expression, which was significantly decreased in the prefrontal cortex of GF mice relative to SPF mice (p = 0.044), correlated with the abundance of a number of key brain metabolites altered by the GF phenotype, including glutamate and glutamine. DiscussionThese results highlight the connection between the GF phenotype, altered brain metabolism, and immediate-early gene expression. The study provides insight into potential mechanisms by which microbiota can regulate neurotransmission through modulation of the host's brain and liver metabolome, which may have implications for stress-related psychiatric disorders such as anxiety.
C1 [Pate, Trinity; Anthony, Daniel C.; Radford-Smith, Daniel E.] Univ Oxford, Dept Pharmacol, Oxford, England.
C3 University of Oxford
RP Radford-Smith, DE (corresponding author), Univ Oxford, Dept Pharmacol, Oxford, England.
EM daniel.radford-smith@pharm.ox.ac.uk
RI Radford-Smith, Daniel/IUQ-7645-2023; Anthony, Daniel/ITT-4206-2023
OI Anthony, Daniel/0000-0003-1380-6655
FU MRC Confidence in Concepts grant; UKRI block grant-Open Access Fund;
   University of Oxford
FX This study was funded by an MRC Confidence in Concepts grant. The APC
   was funded by the UKRI block grant-Open Access Fund, University of
   Oxford.
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NR 64
TC 3
Z9 3
U1 2
U2 8
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1662-5099
J9 FRONT MOL NEUROSCI
JI Front. Molec. Neurosci.
PD APR 20
PY 2023
VL 16
AR 1155620
DI 10.3389/fnmol.2023.1155620
PG 16
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA F2YI9
UT WOS:000981050500001
PM 37152431
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Das, UN
AF Das, Undurti N.
TI Exercise for healthy aging
SO AGRO FOOD INDUSTRY HI-TECH
LA English
DT Article
DE Exercise; aging; myostatin; nitric oxide; follistatin; interleukin;
   tumor necrosis factor; irisin
ID METABOLIC SYNDROME-X; PHYSICAL-ACTIVITY; INTERLEUKIN-6; MUSCLE;
   EXPRESSION; PREVENTION; MYOSTATIN; HUMANS; CANCER; RISK
AB Exercise is useful in the prevention and management of type 2 diabetes, hypertension, coronary heart disease, dementia and depression and helps in healthy aging. Regular exercise is also known to be of significant benefit in the prevention of colon and postmenopausal breast cancer. Exercise helps to preserve muscle mass, prevents osteoporosis and age-associated dementia and Alzheimer's disease and thus, helps in healthy aging. The mechanism(s) responsible for the beneficial actions of exercise include: (a) a 100-fold increase in plasma interleukin-6 (IL-6) levels that triggers anti-oxidant defenses in the body, (b) increased production of brain-derived neurotrophic factor (BDNF), (c) increase in niacinamide that regulates insulin sensitivity, and promote glycemic control, (d) enhanced utilization of polyunsaturated fatty acids (PUFAs) and augmented formation of lipoxins, resolvins, protectins and nitrolipids, potent anti-inflammatory molecules, and (e) increase in the formation of endothelial nitric oxide (NO), a vasodilator and platelet anti-aggregator, that enhances the formation of mitochondria. Exercise is anti-inflammatory in nature and regular exercise has favourable effects on immune system that accounts for its ability to prevent adult diseases.
C1 UND Life Sci, Shaker Hts, OH 44120 USA.
RP Das, UN (corresponding author), UND Life Sci, 13800 Fairhill Rd 321, Shaker Hts, OH 44120 USA.
RI Das, Undurti/A-7918-2009
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NR 30
TC 0
Z9 0
U1 0
U2 32
PU TEKNOSCIENZE PUBL
PI MILANO
PA VIALE BRIANZA 22, 20127 MILANO, ITALY
SN 1722-6996
EI 2035-4606
J9 AGRO FOOD IND HI TEC
JI Agro Food Ind. Hi-Tech
PD SEP-OCT
PY 2012
VL 23
IS 5
BP 72
EP 76
PG 5
WC Biotechnology & Applied Microbiology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Food Science & Technology
GA 027QR
UT WOS:000310368600023
DA 2025-06-11
ER

PT J
AU Saiki, R
   Okazaki, M
   Iwai, S
   Kumai, T
   Kobayashi, S
   Oguchi, K
AF Saiki, Ryo
   Okazaki, Masako
   Iwai, Shinichi
   Kumai, Toshio
   Kobayashi, Shinichi
   Oguchi, Katsuji
TI Effects of pioglitazone on increases in visceral fat accumulation and
   oxidative stress in spontaneously hypertensive hyperlipidemic rats fed a
   high-fat diet and sucrose solution
SO JOURNAL OF PHARMACOLOGICAL SCIENCES
LA English
DT Article
DE visceral fat accumulation; metabolic syndrome model; oxidative stress;
   pioglitazone; anti-oxidant enzyme
ID METABOLIC SYNDROME; ENDOTHELIAL DYSFUNCTION; INSULIN-RESISTANCE;
   ANTIOXIDANT ENZYMES; LIVER-DISEASE; OBESITY; EXPRESSION; MODEL;
   THIAZOLIDINEDIONE; HYPERGLYCEMIA
AB We examined oxidative stress and metabolic characteristics of the spontaneously hypertensive hyperlipidemic rat (SHHR) when it was fed a high-fat diet and sucrose solution (HFDS) after N-G-nitro-L-arginine methyl ester ingestion to develop a rat model of metabolic syndrome. This study was carried out to assess the effects of pioglitazone on levels of lipid peroxide (LPO), Cu,Zn superoxide dismutase (Cu,Zn-SOD), catalase (CAT), glutathione peroxidase (GPx), and non-esterified fatty acids (NEFA) in the plasma and liver tissue in HFDS-SHHR compared with Sprague-Dawley rats (SD). In the HFDS-treated groups, levels of LPO, CAT, GPx, and NEFA were elevated and levels of Cu,Zn-SOD were reduced in the plasma and liver tissue, with a marked accumulation of visceral fat. The changes induced by HFDS feeding were severe in the SHHR model that had essential hypertension and hyperlipidemia, when compared with SD that did not have these essential risk factors. Subcutaneous injection of 10 mg/kg per day of pioglitazone for 2 months significantly restored levels of LPO, CAT, GPx, Cu,Zn-SOD, and NEFA in the HFDS-SHHR group, and visceral fat accumulation was reduced. These results suggest that HFDS-SHHR is a suitable model of metabolic syndrome and that pioglitazone treatment can improve oxidative dysregulation in this rat model.
C1 Showa Univ, Sch Med, Dept Pharmacol, Shinagawa Ku, Tokyo 1428555, Japan.
   St Marianna Univ, Sch Med, Dept Pharmacol, Miyamae Ku, Kawasaki, Kanagawa 2168511, Japan.
C3 Showa University; Saint Marianna University
RP Saiki, R (corresponding author), Showa Univ, Sch Med, Dept Pharmacol, Shinagawa Ku, 1-5-8 Hatanodai, Tokyo 1428555, Japan.
EM ryou-777@zj8.so-net.ne.jp
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NR 51
TC 35
Z9 40
U1 0
U2 2
PU JAPANESE PHARMACOLOGICAL SOC
PI KYOTO
PA EDITORIAL OFF, KANTOHYA BLDG GOKOMACHI-EBISUGAWA NAKAGYO-KU, KYOTO, 604,
   JAPAN
SN 1347-8613
EI 1347-8648
J9 J PHARMACOL SCI
JI J. Pharmacol. Sci.
PD OCT
PY 2007
VL 105
IS 2
BP 157
EP 167
DI 10.1254/jphs.FP0070619
PG 11
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 225RW
UT WOS:000250536100007
PM 17917367
OA Bronze
DA 2025-06-11
ER

PT J
AU Sydsjö, G
AF Sydsjo, Gunilla
TI Long-Term Consequences of Non-Optimal Birth Characteristics
SO AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
LA English
DT Article
DE Birth rate; cohort studies; epidemiology; hospitalization; morbidity;
   preterm infant; reproduction; small-for-gestational-age infant
ID FETAL-GROWTH; PRETERM BIRTH; RISK-FACTORS; OBSTETRIC COMPLICATIONS;
   INTRAUTERINE GROWTH; BEHAVIORAL OUTCOMES; ANTENATAL ANXIETY; PRENATAL
   CORTISOL; EARLY ADULTHOOD; BORN PRETERM
AB Problem
   The intrauterine milieu, gestational length as well as size at birth have a profound impact on the individual's mental, physical health and development both in childhood as well as in adult life.
   Method of study
   This paper reviews the associations between preterm birth and restricted fetal growth with neuro-developmental sequelae, including increased symptoms of psychiatric disorder in childhood and early adulthood. There is also evidence that physical morbidity such as the metabolic syndrome is more common in adult life. In addition, preterm birth and restricted fetal growth have been shown to be related to respiratory disease, infectious disease, and even malignancy. Morbidity, mental and physical as well as personality/intellectual traits hugely impact on family planning and reproductive performance in adults. As restricted fetal growth may alter organ structure and functions, it is likely to also influence subsequent fertility and/or reproductive health.
   Results
   Individuals with non-optimal birth characteristics appears to have a reduction in childbearing and a deviant reproduction pattern compared to controls.
   Conclusion
   Future studies with sophisticated models for measuring the most vulnerable period of birth for children who have a low birth weight or who are at risk for being born preterm are needed to be able to explore the underlying biological mechanisms and also to plan for prevention as well as for interventions during pregnancy.
C1 [Sydsjo, Gunilla] Linkoping Univ, Fac Hlth Sci, Div Obstet & Gynaecol, Dept Clin & Expt Med, Linkoping, Sweden.
C3 Linkoping University
RP Sydsjö, G (corresponding author), Linkoping Univ Hosp, Dept Obstet & Gynaecol, SE-58185 Linkoping, Sweden.
EM gunilla.sydsjo@lio.se
FU Swedish Council for Working Life and Social Research (FAS); Medical
   Research Council of Southeast Sweden (FORSS)
FX The author has received grants from the Swedish Council for Working Life
   and Social Research (FAS) and the Medical Research Council of Southeast
   Sweden (FORSS).
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NR 60
TC 11
Z9 12
U1 0
U2 14
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1046-7408
EI 1600-0897
J9 AM J REPROD IMMUNOL
JI Am. J. Reprod. Immunol.
PD JUL
PY 2011
VL 66
SU 1
SI SI
BP 81
EP 87
DI 10.1111/j.1600-0897.2011.01035.x
PG 7
WC Immunology; Reproductive Biology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Immunology; Reproductive Biology
GA 786WD
UT WOS:000292337700011
PM 21726342
OA Bronze, Green Submitted
DA 2025-06-11
ER

PT J
AU Norouzzadeh, M
   Rashedi, MH
   Azizi, MH
   Teymoori, F
   Maghsoomi, Z
   Shidfar, F
AF Norouzzadeh, Mostafa
   Rashedi, Minoo Hasan
   Azizi, Mohammad Hesam
   Teymoori, Farshad
   Maghsoomi, Zohreh
   Shidfar, Farzad
TI Efficacy and safety of Hibiscus sabdariffa in
   cardiometabolic health: An overview of reviews and updated dose-response
   meta-analysis
SO COMPLEMENTARY THERAPIES IN MEDICINE
LA English
DT Review
DE Hibiscus sabdariffa; Dietary supplements; Natural product;
   Cardiometabolic risk factors; Metabolic syndrome; Hypertension;
   Preventive medicine
ID SOUR TEA; GREEN TEA; BLOOD-PRESSURE; DRIED CALYX; OXIDATIVE STRESS;
   AQUEOUS EXTRACT; LIPID PROFILE; L.; HYPERTENSION; POLYPHENOLS
AB Background: Conventional treatments for cardiometabolic diseases face limitations related to cost, efficacy, and side effects. Hibiscus sabdariffa (HS) is a common food product and a potential alternative. However, previous studies have shown inconsistent results and lacked assessments of result certainty, intervention safety, and subgroup analysis credibility. This study evaluated the efficacy and safety of HS on blood pressure (BP), lipid profiles, glycemic control, anthropometric parameters, inflammatory markers, oxidative stress indicators, and liver enzymes. Methods: To conduct this umbrella review, a systematic search of eligible meta-analyses was performed up to May 2024. The random-effects model was used to synthesize results from individual trials. Quality, certainty, and credibility of evidence were evaluated using the Cochrane Risk of Bias tool, AMSTAR-II, GRADE, and ICEMAN frameworks. Results: Data from 26 randomized controlled trials involving 1797 participants revealed that HS dose- dependently reduced systolic and diastolic BP compared to placebo and other teas. Although no significant differences were found between HS and antihypertensive drugs, HS showed moderate credibility for therapeutic BP reduction (> 10 mmHg), especially in individuals over 50 years, in trials lasting over four weeks, and in those with a low risk of bias. HS also reduced total cholesterol, LDL-C, fasting blood glucose, and increased HDL-C. A minor, clinically insignificant increase in aspartate aminotransferase was observed without elevating adverse event risks. Conclusions: HS showed BP-lowering effects comparable to antihypertensive drugs and beneficial impacts on lipid and glycemic profiles. Although HS is generally considered safe, long-term and therapeutic dosing safety requires careful monitoring.
C1 [Norouzzadeh, Mostafa; Rashedi, Minoo Hasan; Azizi, Mohammad Hesam; Shidfar, Farzad] Iran Univ Med Sci, Inst Studies Med Hist, Persian & Complementary Med, Tehran, Iran.
   [Norouzzadeh, Mostafa; Rashedi, Minoo Hasan; Azizi, Mohammad Hesam; Teymoori, Farshad; Shidfar, Farzad] Iran Univ Med Sci, Sch Publ Hlth, Dept Nutr, Hemmat Highway, Tehran 158754199, Iran.
   [Norouzzadeh, Mostafa; Rashedi, Minoo Hasan; Azizi, Mohammad Hesam; Shidfar, Farzad] Iran Univ Med Sci, Student Res Comm, Tehran, Iran.
   [Norouzzadeh, Mostafa; Rashedi, Minoo Hasan; Teymoori, Farshad] Iran Univ Med Sci, Nutr Sci Res Ctr, Tehran, Iran.
   [Maghsoomi, Zohreh] Iran Univ Med Sci IUMS, Inst Endocrinol & Metab, Res Ctr Prevent Cardiovasc Dis, Tehran, Iran.
C3 Iran University of Medical Sciences; Iran University of Medical
   Sciences; Iran University of Medical Sciences; Iran University of
   Medical Sciences; Iran University of Medical Sciences
RP Shidfar, F (corresponding author), Iran Univ Med Sci, Sch Publ Hlth, Dept Nutr, Hemmat Highway, Tehran 158754199, Iran.
EM farzadshidfar@yahoo.com
RI Shidfar, Farzad/H-6651-2018
OI Norouzzadeh, Mostafa/0000-0003-1336-4447; shidfar,
   Farzad/0000-0002-6531-9253
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NR 102
TC 0
Z9 0
U1 7
U2 7
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0965-2299
EI 1873-6963
J9 COMPLEMENT THER MED
JI Complement. Ther. Med.
PD MAY
PY 2025
VL 89
AR 103135
DI 10.1016/j.ctim.2025.103135
EA JAN 2025
PG 12
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA W9V6G
UT WOS:001421958700001
PM 39870328
OA gold
DA 2025-06-11
ER

PT J
AU Zhao, HW
   Xu, MC
   Han, Y
   Liu, S
   Gong, YT
AF Zhao, Hongwei
   Xu, Mingcheng
   Han, Yu
   Liu, Shuang
   Gong, Yongtai
TI Association between the ratio of serum uric acid to high density
   lipoprotein cholesterol and depressive symptoms in middle-aged and
   elderly Chinese
SO PLOS ONE
LA English
DT Article
ID CORONARY; HISTORY; ADULTS; RISK
AB Background Previous studies have reported that metabolic syndrome is associated with depression. In recent years, the ratio of uric acid to high-density lipoprotein cholesterol (UHR) has been considered as a new effective marker of metabolic syndrome. The purpose of this study was to investigate the association between UHR and depression in people aged 45 years and older in China using the China Health and Retirement Longitudinal Study(CHARLS) database.Methods A total of 10,396 subjects aged 45 years and above were included in this cross-sectional study. The Center for Epidemiologic Studies Depression Scale (CESD-10) was used to facilitate rapid screening and assessment of depression. A CESD-10 score of >= 10 was considered the critical value of depression. UHR was calculated from the ratio of serum uric acid (mg/dL) to high-density lipoprotein cholesterol (mg/dL). Linear regression and logistic regression were used to explore the relationship between UHR and depression, respectively. In addition, subgroup analysis and interaction tests were performed.Results The study found that UHR was negatively associated with depression. In the fully adjusted model, every 1-unit increase in UHR was associated with a 14% lower odds of developing depression (OR = 0.14, 95% CI: 0.05-0.37). Participants in the highest quartile of UHR were 24% less likely to develop depression compared with participants in the lowest quartile (OR = 0.76, 95% CI: 0.67-0.87). The interaction analysis indicates that this negative correlation is more pronounced in the subgroup aged 60 years and above.Conclusion UHR was significantly negatively correlated with depressive symptoms in the middle-aged and elderly Chinese population. However, further prospective studies are needed to accurately elucidate the causal relationship between increased UHR levels and the risk of depression. Therefore, larger cohort studies are needed to support these findings.
C1 [Zhao, Hongwei; Xu, Mingcheng; Han, Yu; Liu, Shuang; Gong, Yongtai] Harbin Med Univ, Dept Cardiol, Affiliated Hosp 1, Harbin, Peoples R China.
C3 Harbin Medical University
RP Liu, S; Gong, YT (corresponding author), Harbin Med Univ, Dept Cardiol, Affiliated Hosp 1, Harbin, Peoples R China.
EM gongth@126.com; 1164746228@qq.com
FU National Natural Science Foundation of China [82000390]
FX This study was supported by the National Natural Science Foundation of
   China (Grant No. 82000390).The funders had no role in study design, data
   collection and analysis, decision to publish, or preparation of the
   manuscript.
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NR 35
TC 0
Z9 0
U1 3
U2 3
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAR 10
PY 2025
VL 20
IS 3
AR e0319465
DI 10.1371/journal.pone.0319465
PG 10
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA Z8R0H
UT WOS:001441498700057
PM 40063865
OA gold
DA 2025-06-11
ER

PT J
AU Kosaki, K
   Yokota, A
   Tanahashi, K
   Myoenzono, K
   Park, J
   Yoshikawa, T
   Yoshida, Y
   Murase, T
   Akari, S
   Nakamura, T
   Maeda, S
AF Kosaki, Keisei
   Yokota, Atsumu
   Tanahashi, Koichiro
   Myoenzono, Kanae
   Park, Jiyeon
   Yoshikawa, Toru
   Yoshida, Yasuko
   Murase, Takayo
   Akari, Seigo
   Nakamura, Takashi
   Maeda, Seiji
TI Associations of circulating xanthine oxidoreductase activity with
   cardiometabolic risk markers in overweight and obese Japanese men: a
   cross-sectional pilot study
SO JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION
LA English
DT Article
DE purine metabolism; uric acid; clustered cardiometabolic risk; obesity;
   insulin resistance
ID OXIDATIVE STRESS; HEART-FAILURE; DEHYDROGENASE; INHIBITION; CONVERSION
AB Circulating xanthine oxidoreductase (XOR) activity may contribute to the pathogenesis of obesity-related adverse cardiometabolic profiles. This pilot study aimed to examine the cross-sectional associations between plasma XOR activity and cardiometabolic risk (CMR) markers in overweight and obese men. In 64 overweight and obese Japanese men (aged 31-63 years), plasma XOR activity and several CMR markers, such as homeostasis model assessment of insulin resistance (HOMA-IR), and clustered CMR score were measured in each participant. Clustered CMR score was constructed based on waist circumference, triglyceride, blood pressure, fasting plasma glucose, and high-density lipoprotein cholesterol. Plasma XOR activity in overweight and obese men was positively associated with the body mass index, waist circumference, visceral fat area, body fat mass, hemoglobin A1c, serum 8-hydroxy-2'-deoxyguanosine, HOMA-IR, and clustered CMR score and was inversely associated with handgrip strength and high-density lipoprotein cholesterol. Multiple linear regression analysis further demonstrated that the associations of plasma XOR activity with HOMA-IR and the clustered CMR score remained significant after adjustment for covariates including uric acid. Our data demonstrate that circulating XOR activity was independently associated, albeit modestly, with HOMA-IR and the clustered CMR score. These preliminary findings suggest that circulating XOR activity can potentially be one of the preventive targets and biomarkers of cardiometabolic disorders in overweight and obese men.
C1 [Kosaki, Keisei; Park, Jiyeon; Maeda, Seiji] Univ Tsukuba, Fac Hlth & Sport Sci, 1-1-1 Tennodai, Tsukuba, Ibaraki 3058574, Japan.
   [Yokota, Atsumu; Myoenzono, Kanae] Univ Tsukuba, Grad Sch Comprehens Human Sci, 1-1-1 Tennodai, Tsukuba, Ibaraki 3058574, Japan.
   [Tanahashi, Koichiro] Kyoto Pharmaceut Univ, Dept Hlth & Sports Sci, Yamashina Ku, 5 Misasaginakauchi Cho, Kyoto 6078414, Japan.
   [Myoenzono, Kanae] Japan Inst Sport Sci, Kita Ku, 3-15-1 Nishigaoka, Tokyo 1150056, Japan.
   [Yoshikawa, Toru] Ryutsu Keizai Univ, Fac Hlth & Sport Sci, 120 Ryugasaki, Ibaraki 3018555, Japan.
   [Yoshida, Yasuko] Tsukuba Int Univ, Fac Hlth Sci, 6-20-1 Manabe, Tsuchiura, Ibaraki 3000051, Japan.
   [Murase, Takayo; Akari, Seigo; Nakamura, Takashi] Sanwa Kagaku Kenkyusho Co Ltd, Hokusei Cho, Inabe, Mie 5110406, Japan.
   [Maeda, Seiji] Waseda Univ, Fac Sport Sci, 2-579-15 Mikajima, Tokorozawa, Saitama 3591192, Japan.
C3 University of Tsukuba; University of Tsukuba; Kyoto Pharmaceutical
   University; Ryutsu Keizai University; Sanwa Kagaku Kenkyusho Co., Ltd.;
   Waseda University
RP Maeda, S (corresponding author), Univ Tsukuba, Fac Hlth & Sport Sci, 1-1-1 Tennodai, Tsukuba, Ibaraki 3058574, Japan.; Maeda, S (corresponding author), Waseda Univ, Fac Sport Sci, 2-579-15 Mikajima, Tokorozawa, Saitama 3591192, Japan.
EM maeda.seiji.gn@u.tsukuba.ac.jp
FU JSPS KAKENHI [JP19H03995]; Ministry of Education, Culture, Sports,
   Science, and Technology, Japan; MEXT Leading Initiative for Excellent
   Young Researchers [JPMXS0320200234]
FX The authors are grateful to the members of our laboratory (University of
   Tsukuba) for their technical assistance. This work was supported in part
   by JSPS KAKENHI Grant Number JP19H03995 from the Ministry of Education,
   Culture, Sports, Science, and Technology, Japan and MEXT Leading
   Initiative for Excellent Young Researchers Grant Number JPMXS0320200234.
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NR 30
TC 0
Z9 0
U1 0
U2 0
PU JOURNAL CLINICAL BIOCHEMISTRY & NUTRITION
PI KYOTO
PA KYOTO PREFECTURAL UNIV MED, GRAD SCH MEDICAL SCIENCE, DEPT MOLECULAR
   GASTROENTEROLOGY & HEPATOLOGY, KYOTO, 602-8566, JAPAN
SN 0912-0009
EI 1880-5086
J9 J CLIN BIOCHEM NUTR
JI J. Clin. Biochem. Nutr.
PD SEP
PY 2022
VL 71
IS 2
BP 122
EP 128
DI 10.3164/jcbn.21-118
PG 7
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 4L6EU
UT WOS:000852724200007
PM 36213790
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Singh, R
   Jain, S
   Paliwal, V
   Verma, K
   Paliwal, S
   Sharma, S
AF Singh, Ritu
   Jain, Smita
   Paliwal, Vartika
   Verma, Kanika
   Paliwal, Sarvesh
   Sharma, Swapnil
TI Does Metabolic Manager Show Encouraging Outcomes in Alzheimer's?:
   Challenges and Opportunity for Protein Tyrosine Phosphatase 1b
   Inhibitors
SO DRUG DEVELOPMENT RESEARCH
LA English
DT Review
DE metabolic syndrome; neurodegeneration; neuroinflammation; oxidative
   stress; protein tyrosine phosphatase 1b enzyme
ID BRAIN INSULIN-RESISTANCE; STRUCTURE-BASED DESIGN; PTP1B INHIBITORS;
   AMYLOID-BETA; MOUSE MODEL; A-BETA; SELECTIVE INHIBITOR;
   THIAMINE-DEFICIENCY; ACID DERIVATIVES; CA2+ RELEASE
AB Protein tyrosine phosphatase 1b (PTP1b) is a member of the protein tyrosine phosphatase (PTP) enzyme group and encoded as PTP1N gene. Studies have evidenced an overexpression of the PTP1b enzyme in metabolic syndrome, anxiety, schizophrenia, neurodegeneration, and neuroinflammation. PTP1b inhibitor negatively regulates insulin and leptin pathways and has been explored as an antidiabetic agent in various clinical trials. Notably, the preclinical studies have shown that recuperating metabolic dysfunction and dyshomeostasis can reverse cognition and could be a possible approach to mitigate multifaceted Alzheimer's disease (AD). PTP1b inhibitor thus has attracted attention in neuroscience, though the development is limited to the preclinical stage, and its exploration in large clinical trials is warranted. This review provides an insight on the development of PTP1b inhibitors from different sources in diabesity. The crosstalk between metabolic dysfunction and insulin insensitivity in AD and type-2 diabetes has also been highlighted. Furthermore, this review presents the significance of PTP1b inhibition in AD based on pathophysiological facets, and recent evidences from preclinical and clinical studies.
C1 [Singh, Ritu; Jain, Smita; Paliwal, Vartika; Paliwal, Sarvesh; Sharma, Swapnil] Banasthali Vidyapith, Dept Pharm, Banasthali, Rajasthan, India.
   [Verma, Kanika] LSU Hlth Sci Ctr Shreveport, Dept Internal Med, Div Cardiol, Shreveport, LA USA.
C3 Banasthali Vidyapith; Louisiana State University System; Louisiana State
   University Health Sciences Center at Shreveport
RP Paliwal, S; Sharma, S (corresponding author), Banasthali Vidyapith, Dept Pharm, Banasthali, Rajasthan, India.
EM psarvesh@banasthali.ac.in; skspharmacology@gmail.com
RI Sharma, Swapnil/AAV-4850-2020; Jain, Smita/KLB-9548-2024; Paliwal,
   Sarvesh/GQQ-1555-2022; Verma, Kanika/GZA-3489-2022
OI Sharma, Swapnil/0000-0003-2639-7096
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NR 225
TC 0
Z9 0
U1 1
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0272-4391
EI 1098-2299
J9 DRUG DEVELOP RES
JI Drug Dev. Res.
PD DEC
PY 2024
VL 85
IS 8
AR e70026
DI 10.1002/ddr.70026
PG 25
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA O7I2E
UT WOS:001372810500001
PM 39655712
DA 2025-06-11
ER

PT J
AU Capuron, L
   Su, S
   Miller, AH
   Bremner, JD
   Goldberg, J
   Vogt, GJ
   Maisano, C
   Jones, L
   Murrah, NV
   Vaccarino, V
AF Capuron, Lucile
   Su, Shaoyong
   Miller, Andrew H.
   Bremner, J. Douglas
   Goldberg, Jack
   Vogt, Gerald J.
   Maisano, Carisa
   Jones, Linda
   Murrah, Nancy V.
   Vaccarino, Viola
TI Depressive Symptoms and Metabolic Syndrome: Is inflammation the
   Underlying Link?
SO BIOLOGICAL PSYCHIATRY
LA English
DT Article
DE Cytokines; depression; inflammation; metabolic syndrome; mood
ID C-REACTIVE PROTEIN; CORONARY-HEART-DISEASE; WHITE ADIPOSE-TISSUE;
   MIDDLE-AGED MEN; INTERFERON-ALPHA; INSULIN-RESISTANCE; CANCER-PATIENTS;
   OBESITY; CYTOKINES; RISK
AB Background: Behavioral alterations, including depression, are frequent in individuals with the metabolic syndrome (MetS). Recent findings suggest that chronic activation of innate immunity might be involved. The objective of this study was to examine the relationship between MetS and depressive symptoms and to elucidate the involvement of inflammation in this relationship.
   Methods: Participants were 323 male twins, with and without MetS and free of symptomatic cardiovascular disease, drawn from the Vietnam Era Twin Registry. Depressive symptoms were measured with the Beck Depression Inventory (BDI). Inflammatory status was assessed using C-reactive protein (CRP) and interleukin-6 (IL-6); twins with both CRP and IL-6 levels above the median were classified as having an elevated inflammatory status. Factor analysis was performed on individual BDI items to extract specific symptom dimensions (neurovegetative, mood, affective-cognitive).
   Results: Subjects with MetS had more depressive symptoms than those without. Depressive symptoms with neurovegetative features were more common and more robustly associated with MetS. Both the BDI total score and each symptom subscore were associated with inflammatory biomarkers. After adjusting for age, education, and smoking status, the MetS was significantly associated with the BDI total score and the neurovegetative score. After further adjusting for inflammation, the coefficient for MetS decreased somewhat but remained statistically significant for the BDI neurovegetative subscore. When controlling for the MetS, inflammation remained significantly associated with the BDI mood subscore.
   Conclusions: The MetS is associated with higher depressive symptomatology characterized primarily by neurovegetative features. Inflammation is one determinant of depressive symptoms in individuals with MetS.
C1 [Capuron, Lucile] Univ Bordeaux 2, Lab Psychoneuroimmunol Nutr & Genet PSYNUGEN, CNRS 5226, INRA,UMR 1286, F-33076 Bordeaux, France.
   [Su, Shaoyong; Maisano, Carisa; Jones, Linda; Murrah, Nancy V.; Vaccarino, Viola] Emory Univ, Sch Med, Dept Med, Div Cardiol, Atlanta, GA USA.
   [Capuron, Lucile; Miller, Andrew H.; Bremner, J. Douglas; Vogt, Gerald J.] Emory Univ, Sch Med, Dept Psychiat & Behav Sci, Atlanta, GA USA.
   [Vaccarino, Viola] Emory Univ, Dept Epidemiol, Rollins Sch Publ Hlth, Atlanta, GA USA.
   [Goldberg, Jack] Univ Washington, Sch Publ Hlth & Community Med, Dept Epidemiol, Seattle, WA 98195 USA.
   Univ Washington, Sch Publ Hlth & Community Med, Vietnam Era Twin Registry, Seattle, WA 98195 USA.
C3 INRAE; Universite de Bordeaux; Institut National de la Sante et de la
   Recherche Medicale (Inserm); Emory University; Emory University; Emory
   University; Rollins School Public Health; University of Washington;
   University of Washington Seattle; University of Washington; University
   of Washington Seattle
RP Capuron, L (corresponding author), Univ Bordeaux 2, Lab Psychoneuroimmunol Nutr & Genet PSYNUGEN, CNRS 5226, INRA,UMR 1286, 146 Rue Leo Saignat, F-33076 Bordeaux, France.
EM lucile.capuron@bordeaux.inra.fr
RI Bremner, James/B-1632-2013; Vaccarino, Viola/AAW-5600-2020; Miller,
   Andrew/AFL-5625-2022
OI Bremner, James Douglas/0000-0003-1633-6433; Capuron,
   Lucile/0000-0002-2060-5918; Vaccarino, Laura Viola/0000-0002-9054-0654
FU National Institutes of Health [K24HL077506, R01 HL68630, R01 AG026255];
   Emory University General Clinical Research Center [MO1-RR00039];
   American Heart Association [0245115N]; United States Department of
   Veterans Affairs; American Heart Association (AHA) [0245115N] Funding
   Source: American Heart Association (AHA)
FX This study was supported by K24HL077506, R01 HL68630, and R01 AG026255
   from the National Institutes of Health, Emory University General
   Clinical Research Center MO1-RR00039; and Grant 0245115N from the
   American Heart Association.The United States Department of Veterans
   Affairs has provided financial support for the development and
   maintenance of the Vietnam Era Twin (VET) Registry. Numerous
   organizations have provided invaluable assistance in the conduct of this
   study, including: Department of Defense; National Personnel Records
   Center, National Archives and Records Administration; the Internal
   Revenue Service; National Institutes of Health; National Opinion
   Research Center; National Research Council, National Academy of
   Sciences; and the Institute for Survey Research, Temple University. Most
   importantly, we gratefully acknowledge the continued cooperation and
   participation of the members of the VET Registry and their families.
   Without their contribution, this research would not have been
   possible.The authors reported no biomedical financial interests or
   potential conflicts of interest.
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NR 36
TC 165
Z9 180
U1 0
U2 16
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD NOV 15
PY 2008
VL 64
IS 10
BP 896
EP 900
DI 10.1016/j.biopsych.2008.05.019
PG 5
WC Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Psychiatry
GA 372OW
UT WOS:000260911900011
PM 18597739
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Feillet-Coudray, C
   Fouret, G
   Elle, RE
   Rieusset, J
   Bonafos, B
   Chabi, B
   Crouzier, D
   Zarkovic, K
   Zarkovic, N
   Ramos, J
   Badia, E
   Murphy, MP
   Cristol, JP
   Coudray, C
AF Feillet-Coudray, Christine
   Fouret, Gillen
   Elle, Raymond Ebabe
   Rieusset, Jennifer
   Bonafos, Beatrice
   Chabi, Beatrice
   Crouzier, David
   Zarkovic, Kamelija
   Zarkovic, Neven
   Ramos, Jeanne
   Badia, Eric
   Murphy, Michael P.
   Cristol, Jean Paul
   Coudray, Charles
TI The mitochondrial-targeted antioxidant MitoQ ameliorates metabolic
   syndrome features in obesogenic diet-fed rats better than Apocynin or
   Allopurinol
SO FREE RADICAL RESEARCH
LA English
DT Article
DE antioxidants; free radicals; hepatic steatosis; high fat diet; insulin
   resistance; metabolic syndrome; mitochondria; MitoQ; NADPH oxidase;
   obesity; oxidative stress; xanthine oxidase
ID FATTY LIVER-DISEASE; OXIDATIVE STRESS; NADPH OXIDASE;
   INSULIN-RESISTANCE; INHIBITOR; GLUTATHIONE; PRODUCTS; PREVENTS; ACIDS
AB The prevalence of metabolic syndrome (MetS) components including obesity, dyslipidemia, insulin resistance (IR), and hepatic steatosis is rapidly increasing in wealthy societies. It is accepted that inflammation/oxidative stress are involved in the initiation/evolution of the MetS features. The present work was designed to evaluate the effects of three major cellular ROS production systems on obesity, glucose tolerance, and hepatic steatosis development and on oxidative stress onset. To do so, 40 young male Sprague-Dawley rats were divided into 5 groups: 1-control group, 2-high fat (HF) group (60% energy from fat), 3-HF + MitoQ (mitochondrial ROS scavenger), 4-HF + Apocynin (NADPH oxidase inhibitor), 5-HF + Allopurinol (xanthine oxidase inhibitor). After 8 weeks of these treatments, surrogate MetS, mitochondrial function, and oxidative stress markers were measured in blood and liver. As expected, rats that were fed the HF diet exhibited increased body weight, glucose intolerance, overt hepatic steatosis, and increased hepatic oxidative stress. The impacts of the studied ROS inhibitors on these aspects of the MetS were markedly different. MitoQ showed the most clinically relevant effects, attenuating body weight gain and glucose intolerance provoked by the HF diet. Both Apocynin and Allopurinol showed limited effects suggesting secondary roles of xanthine oxidase (XO) or NADPH oxidase-dependent ROS production in the onset of oxidative stress-dependent obesity, glucose intolerance, and hepatic steatosis process. Thus, MitoQ revealed the central role of mitochondrial oxidative stress in the development of MetS and suggested that mitochondria-targeted antioxidants may be worth considering as potentially helpful therapies for MetS features.
C1 [Feillet-Coudray, Christine; Fouret, Gillen; Bonafos, Beatrice; Chabi, Beatrice; Coudray, Charles] INRA, UMR Dynam Musculaire & Metab 866, F-34060 Montpellier, France.
   [Elle, Raymond Ebabe; Badia, Eric; Cristol, Jean Paul] Univ Montpellier 2, Univ Montpellier 1, UMR NUTRIPASS IRD 204, Montpellier, France.
   [Rieusset, Jennifer] INSERM, Fac Med Lyon Sud, UMR U1060, Oullins, France.
   [Crouzier, David] CRSSA, Unite BCM, La Tronche, France.
   [Zarkovic, Kamelija] Univ Zagreb, Sch Med, Div Pathol, Clin Hosp Ctr, Zagreb 41000, Croatia.
   [Zarkovic, Neven] Rudjer Boskovic Inst, Lab Oxidat Stress, Zagreb, Croatia.
   [Ramos, Jeanne] CHU Gui Chauliac, Anat Pathol Lab, Montpellier, France.
   [Murphy, Michael P.] MRC Mitochondrial Biol Unit, Cambridge, England.
C3 INRAE; Universite de Montpellier; Universite de Montpellier; Institut de
   Recherche pour le Developpement (IRD); Universite Claude Bernard Lyon 1;
   Institut National de la Sante et de la Recherche Medicale (Inserm);
   University of Zagreb; Rudjer Boskovic Institute; Universite de
   Montpellier; CHU de Montpellier
RP Coudray, C (corresponding author), INRA, UMR Dynam Musculaire & Metab 866, 2 Pl Viala, F-34060 Montpellier, France.
EM coudray@supagro.inra.fr
RI COUDRAY, Charles/AGG-4757-2022; Chabi, Beatrice/AAI-6545-2020; Rieusset,
   Jennifer/F-1595-2018; Zarkovic, Neven/AAG-5836-2019; Murphy,
   Michael/C-2120-2009
OI Carmen, Team1/0000-0003-4234-1746; Rieusset,
   Jennifer/0000-0002-1587-2253; BADIA, Eric/0000-0002-8922-9834; Coudray,
   Charles/0000-0003-2680-7796; Lab, Carmen/0000-0002-5935-3236; Zarkovic,
   Neven/0000-0001-5032-0369; CHABI, Beatrice/0000-0002-5604-5668; Murphy,
   Michael/0000-0003-1115-9618; Carmen, Team2/0000-0001-9867-5724
FU French Lipid Nutrition Group; National Institute for Agronomic Research;
   Human nutrition Department; EU project [CM0603]; MRC [MC_U105663142]
   Funding Source: UKRI
FX The authors acknowledge the financial support of the French Lipid
   Nutrition Group and the National Institute for Agronomic Research and,
   in particular, the Human nutrition Department (Alim-H department). The
   support from the side of the EU project CM0603 is also kindly
   acknowledged. The authors wish to thank Marie-Agnes Chauvin for
   completion of Oxyblot and Oxphos western blots. The authors also wish to
   thank the staff of the animal facilities for animal use.
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NR 65
TC 63
Z9 63
U1 0
U2 22
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1071-5762
EI 1029-2470
J9 FREE RADICAL RES
JI Free Radic. Res.
PD OCT
PY 2014
VL 48
IS 10
BP 1232
EP 1246
DI 10.3109/10715762.2014.945079
PG 15
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA AO3LQ
UT WOS:000341231200010
PM 25066801
DA 2025-06-11
ER

PT J
AU Bayes, A
   Tavella, G
   Parker, G
AF Bayes, Adam
   Tavella, Gabriela
   Parker, Gordon
TI The biology of burnout: Causes and consequences
SO WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
LA English
DT Review
DE Stress; biological psychiatry; cortisol; depression; biochemical markers
ID CORTISOL AWAKENING RESPONSE; TERM SICK LEAVE; COGNITIVE PERFORMANCE;
   CLINICAL BURNOUT; ALLOSTATIC LOAD; HPA AXIS; PSYCHOLOGICAL DISTRESS;
   HEALTH CONSEQUENCES; MAJOR DEPRESSION; FOLLOW-UP
AB Objectives Burnout is a state of exhaustion resulting from prolonged and excessive workplace stress. We sought to examine biological underpinnings of burnout, focussing on mechanisms and physical consequences. Methods We searched the literature on burnout and evaluated studies examining biological parameters in patient populations (i.e. 'clinical' burnout) as well as in individuals from the general population judged as having some degree of burnout evaluated using a dimensional approach. Results Findings suggest that burnout is associated with sustained activation of the autonomic nervous system and dysfunction of the sympathetic adrenal medullary axis, with alterations in cortisol levels. Limited studies have also shown altered immune function and changes in other endocrine systems. Consequences of burnout include increased allostatic load, structural and functional brain changes, excito-toxicity, systemic inflammation, immunosuppression, metabolic syndrome, cardiovascular disease and premature death. Limitations of studies include variability in study populations, low specificity of burnout measures, and mostly cross-sectional studies precluding examination of changes across the course of burnout. Conclusions Further examination of biological mechanisms of burnout would benefit from more homogeneous clinical samples, challenge tests and prospective studies. This would assist in differentiation from conditions such as depression and aid with development of specific treatment targets for burnout.
C1 [Bayes, Adam; Tavella, Gabriela; Parker, Gordon] UNSW, Sch Psychiat, Sydney, NSW, Australia.
   [Bayes, Adam] Black Dog Inst, Sydney, NSW, Australia.
C3 University of New South Wales Sydney; Black Dog Institute
RP Bayes, A (corresponding author), UNSW, Level 1,AGSM Bldg, Sydney, NSW 2052, Australia.
EM a.bayes@unsw.edu.au
RI Tavella, Gabriela/HMV-7104-2023
OI Parker, Gordon/0000-0003-3424-5519
FU National Health and Medical Research Council [1037196]
FX This work was supported by National Health and Medical Research Council
   (1037196).
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NR 103
TC 74
Z9 85
U1 5
U2 68
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1562-2975
EI 1814-1412
J9 WORLD J BIOL PSYCHIA
JI World J. Biol. Psychiatry
PD OCT 21
PY 2021
VL 22
IS 9
BP 686
EP 698
DI 10.1080/15622975.2021.1907713
EA APR 2021
PG 13
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychiatry
GA WP9FC
UT WOS:000646228900001
PM 33783308
DA 2025-06-11
ER

PT J
AU Rossi, JLS
   Barbalho, SM
   de Araujo, RR
   Bechara, MD
   Sloan, KP
   Sloan, LA
AF Silveira Rossi, Joao Leonardo
   Barbalho, Sandra Maria
   de Araujo, Renan Reverete
   Bechara, Marcelo Dib
   Sloan, Katia Portero
   Sloan, Lance Alan
TI Metabolic syndrome and cardiovascular diseases: Going beyond traditional
   risk factors
SO DIABETES-METABOLISM RESEARCH AND REVIEWS
LA English
DT Review
DE cardiorenal; cardiovascular diseases; inflammation; metabolic syndrome;
   oxidative stress
ID GLYCATION END-PRODUCTS; OXIDATIVE STRESS; OLIVE OIL; INFLAMMATION;
   ATHEROSCLEROSIS; PATHOGENESIS; MECHANISMS; BIOMARKERS; FRAILTY
AB Metabolic syndrome (MS) is a chronic non-infective syndrome characterised clinically by a set of vascular risk factors that include insulin resistance, hypertension, abdominal obesity, impaired glucose metabolism, and dyslipidaemia. These risk factors are due to a pro-inflammatory state, oxidative stress, haemodynamic dysfunction, and ischaemia, which overlap in 'dysmetabolic' patients. This review aimed to evaluate the relationship between the traditional components of MS with cardiovascular disease (CVD), inflammation, and oxidative stress. MEDLINE-PubMed, EMBASE, and Cochrane databases were searched. Chronic low-grade inflammatory states and metaflammation are often accompanied by metabolic changes directly related to CVD incidence, such as diabetes mellitus, hypertension, and obesity. Moreover, the metaflammation is characterised by an increase in the serum concentration of pro-inflammatory cytokines, mainly interleukin-1 beta (IL-1 beta), IL-6, and tumour necrosis factor-alpha (TNF-alpha), originating from the chronically inflamed adipose tissue and associated with oxidative stress. The increase of reactive oxygen species overloads the antioxidant systems causing post-translational alterations of proteins, lipids, and DNA leading to oxidative stress. Hyperglycaemia contributes to the increase in oxidative stress and the production of advanced glycosylation end products (AGEs) which are related to cellular and molecular dysfunction. Oxidative stress and inflammation are associated with cellular senescence and CVD. CVD should not be seen only as being triggered by classical MS risk factors. Atherosclerosis is a multifactorial pathological process with several triggering and aetiopathogenic mechanisms. Its medium and long-term repercussions, however, invariably constitute a significant cause of morbidity and mortality. Implementing preventive and therapeutic measures against oxy-reductive imbalances and metaflammation states has unquestionable potential for favourable clinical outcomes in cardiovascular medicine.
C1 [Silveira Rossi, Joao Leonardo; Barbalho, Sandra Maria; de Araujo, Renan Reverete; Bechara, Marcelo Dib] Univ Marilia, Sch Med, Dept Biochem & Pharmacol, Av Higino Muzzi Filho 1001, BR-15525902 Marilia, SP, Brazil.
   [Barbalho, Sandra Maria] Univ Marilia, Postgrad Program Struct & Funct Interact Rehabil, Marilia, SP, Brazil.
   [Barbalho, Sandra Maria] Sch Food & Technol Marilia, Marilia, SP, Brazil.
   [Sloan, Katia Portero; Sloan, Lance Alan] Texas Inst Kidney & Endocrine Disorders, Lufkin, TX USA.
   [Sloan, Lance Alan] Univ Texas Med Branch, Galveston, TX 77555 USA.
C3 Universidade de Marilia; Universidade de Marilia; University of Texas
   System; University of Texas Medical Branch Galveston
RP Barbalho, SM (corresponding author), Univ Marilia, Sch Med, Dept Biochem & Pharmacol, Av Higino Muzzi Filho 1001, BR-15525902 Marilia, SP, Brazil.
EM smbarbalho@gmail.com
RI Sloan, Katia/MXM-3742-2025; Sloan, Lance/ACF-5235-2022; barbalho,
   sandra/Z-3515-2019
OI barbalho, sandra/0000-0002-5035-876X
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NR 101
TC 321
Z9 327
U1 15
U2 128
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1520-7552
EI 1520-7560
J9 DIABETES-METAB RES
JI Diabetes-Metab. Res. Rev.
PD MAR
PY 2022
VL 38
IS 3
AR e3502
DI 10.1002/dmrr.3502
EA OCT 2021
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA ZL3OT
UT WOS:000707418600001
PM 34614543
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Kim, S
   Nam, Y
   Shin, SJ
   Park, YH
   Jeon, SG
   Kim, JI
   Kim, MJ
   Moon, M
AF Kim, Sujin
   Nam, Yunkwon
   Shin, Soo Jung
   Park, Yong Ho
   Jeon, Seong Gak
   Kim, Jin-il
   Kim, Min-Jeong
   Moon, Minho
TI The Potential Roles of Ghrelin in Metabolic Syndrome and Secondary
   Symptoms of Alzheimer's Disease
SO FRONTIERS IN NEUROSCIENCE
LA English
DT Review
DE ghrelin; Alzheimer's disease; metabolic syndrome; depression; sleep-wake
   disturbances; abnormal eating behaviors
ID DES-ACYL GHRELIN; PROTEIN-KINASE-A; NEUROPEPTIDE-Y; OLFACTORY
   BULBECTOMY; INSULIN-RESISTANCE; PERIPHERAL GHRELIN; PLASMA GHRELIN;
   MOUSE MODEL; FOOD-INTAKE; COGNITIVE DYSFUNCTION
AB Although the major causative factors of Alzheimer's disease (AD) are the accumulation of amyloid beta and hyperphosphorylated tau, AD can also be caused by metabolic dysfunction. The major clinical symptom of AD is cognitive dysfunction. However, AD is also accompanied by various secondary symptoms such as depression, sleep-wake disturbances, and abnormal eating behaviors. Interestingly, the orexigenic hormone ghrelin has been suggested to have beneficial effects on AD-related metabolic syndrome and secondary symptoms. Ghrelin improves lipid distribution and alters insulin sensitivity, effects that are hypothesized to delay the progression of AD. Furthermore, ghrelin can relieve depression by enhancing the secretion of hormones such as serotonin, noradrenaline, and orexin. Moreover, ghrelin can upregulate the expression of neurotrophic factors such as brain-derived neurotrophic factor and modulate the release of proinflammatory cytokines such as tumor necrosis factor alpha and interleukin 1 beta. Ghrelin alleviates sleep-wake disturbances by increasing the levels of melatonin, melanin-concentrating hormone. Ghrelin reduces the risk of abnormal eating behaviors by increasing neuropeptide Y and gamma-aminobutyric acid. In addition, ghrelin increases food intake by inhibiting fatty acid biosynthesis. However, despite the numerous studies on the role of ghrelin in the AD-related pathology and metabolic disorders, there are only a few studies that investigate the effects of ghrelin on secondary symptoms associated with AD. In this mini review, our purpose is to provide the insights of future study by organizing the previous studies for the role of ghrelin in AD-related pathology and metabolic disorders.
C1 [Kim, Sujin; Nam, Yunkwon; Shin, Soo Jung; Park, Yong Ho; Jeon, Seong Gak; Kim, Min-Jeong; Moon, Minho] Konyang Univ, Coll Med, Dept Biochem, Daejeon, South Korea.
   [Jeon, Seong Gak] Korea Brain Res Inst KBRI, Dept Neural Dev & Dis, Daegu, South Korea.
   [Kim, Jin-il] Jeju Natl Univ, Coll Nursing, Dept Nursing, Jeju Si, South Korea.
C3 Konyang University; Konyang University Hospital; Korea Brain Research
   Institute (KBRI); Jeju National University
RP Moon, M (corresponding author), Konyang Univ, Coll Med, Dept Biochem, Daejeon, South Korea.
EM hominmoon@konyang.ac.kr
RI Kim, Soo-Hyun/D-1577-2019; Kim, Woo/D-2733-2015
OI Nam, Yunkwon/0000-0002-0101-7766; Jeon, Seong-gak/0000-0002-3529-3259
FU Basic Science Research Program of the National Research Foundation of
   Korea (NRF) - Ministry of Science, ICT and Future Planning
   [NRF-2018R1D1A3B07041059]; Cooperative Research Program for Agriculture
   Science and Technology Development, Rural Development Administration,
   South Korea [PJ01319901, PJ01428603]
FX This work was supported by the Basic Science Research Program of the
   National Research Foundation of Korea (NRF), which is funded by the
   Ministry of Science, ICT and Future Planning (NRF-2018R1D1A3B07041059)
   as well as by the Cooperative Research Program for Agriculture Science
   and Technology Development (project nos. PJ01319901 and PJ01428603),
   Rural Development Administration, South Korea.
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NR 160
TC 12
Z9 12
U1 0
U2 13
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1662-453X
J9 FRONT NEUROSCI-SWITZ
JI Front. Neurosci.
PD SEP 24
PY 2020
VL 14
AR 583097
DI 10.3389/fnins.2020.583097
PG 11
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology
GA NX9KF
UT WOS:000576019900001
PM 33071750
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Ko, JK
   Han, KM
   Shin, C
   Lee, SH
   Han, C
   Kim, YK
   Yoon, HK
   Ko, YH
AF Ko, Jeong-Kyung
   Han, Kyu-Man
   Shin, Cheolmin
   Lee, Seung-Hoon
   Han, Changsu
   Kim, Yong-Ku
   Yoon, Ho-Kyong
   Ko, Young-Hoon
TI Association of metabolic syndrome and its components with suicidal
   ideation and depression in adults: A nationally representative sample of
   the Korean population
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Depressive symptoms; Suicidal ideation; Patient Health Questionnaire-9;
   Metabolic syndrome; Glucose; Triglyceride
ID SELF-RATED HEALTH; LOW SERUM-CHOLESTEROL; SEROTONERGIC RESPONSIVITY;
   CHRONIC DISEASES; MORTALITY; SYMPTOMS; COMMUNITY; DISORDER;
   ABNORMALITIES; ATTEMPTERS
AB Background: Few studies have evaluated the association of depressive symptoms and suicidal ideation with metabolic syndrome (MetS) and its components. This study examined the associations of MetS and its components with suicidal ideation and depression and determined the mediation effect of self-rated health (SRH) on these associations.
   Methods: This study was conducted using cross-sectional data on 9867 people (aged >= 19 years old) collected in 2014 and 2016 from a nationally representative sample of the Korean National Health and Nutrition Examination Survey. The associations of MetS with suicidal ideation and depression were estimated after adjusting for potential confounding factors using logistic regression analyses, and a mediation analysis by Hayes and Preacher was used to estimate the mediation pathway between such associations through SRH.
   Result: After adjusting for confounding factors, suicidal ideation was associated with MetS. Depressive symptoms and suicidal ideation were associated with two components of MetS: high triglyceride level and high fasting plasma glucose level. In the mediation analysis, we found a significant mediating effect of SRH on the association between high triglyceride level and suicidal ideation.
   Limitations: We cannot elucidate causal relationships because of the cross-sectional design.
   Conclusion: Our study provides the implication that a high triglyceride level and elevated fasting plasma glucose level may contribute suicidal risk and depressive symptoms in adults and that SRH may contribute to the development of suicidal ideation in adults via the apparent interaction with one of the components of MetS-high triglyceride level.
C1 [Ko, Jeong-Kyung; Han, Kyu-Man; Shin, Cheolmin; Lee, Seung-Hoon; Han, Changsu; Kim, Yong-Ku; Yoon, Ho-Kyong; Ko, Young-Hoon] Korea Univ, Coll Med, Dept Psychiat, Seoul, South Korea.
C3 Korea University; Korea University Medicine (KU Medicine)
RP Ko, YH (corresponding author), Korea Univ, Coll Med, Dept Psychiat, Seoul, South Korea.
EM koyh@korea.ac.kr
RI Kim, Yong-Ku/AAF-1680-2020; Shin, Cheolmin/AAX-7092-2020; Lee,
   Seung-Hoon/HPC-3773-2023; Han, Changsu/H-9926-2013
OI Lee, Seung-Hoon/0000-0001-5341-0933; Han, Kyu-Man/0000-0002-1982-4216;
   Shin, Cheolmin/0000-0002-8232-2921; Han, Changsu/0000-0002-4021-8907;
   Ko, Young-Hoon/0000-0002-5352-2158
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NR 57
TC 14
Z9 17
U1 0
U2 7
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD APR 15
PY 2019
VL 249
BP 319
EP 326
DI 10.1016/j.jad.2019.02.049
PG 8
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA HO6FL
UT WOS:000461024900042
PM 30802697
DA 2025-06-11
ER

PT J
AU Hou, J
   Liu, CY
   Yao, P
   Chen, WH
   He, MA
   Wang, YJ
   Liang, Y
   Miao, XP
   Wei, S
   Xu, T
   Fang, WM
   Zhu, J
   Li, XL
   Hu, FB
   Wu, TC
   Yang, HD
   Yuan, J
AF Hou, Jian
   Liu, Chuanyao
   Yao, Ping
   Chen, Weihong
   He, Meian
   Wang, Youjie
   Liang, Yuan
   Miao, Xiaoping
   Wei, Sheng
   Xu, Tian
   Fang, Weimin
   Zhu, Jiang
   Li, Xiulou
   Hu, Frank B.
   Wu, Tangchun
   Yang, Handong
   Yuan, Jing
TI Association of Adiposity Indices with Platelet Distribution Width and
   Mean Platelet Volume in Chinese Adults
SO PLOS ONE
LA English
DT Article
ID BODY-MASS INDEX; TO-HEIGHT RATIO; WAIST CIRCUMFERENCE; METABOLIC
   SYNDROME; CARDIOMETABOLIC RISK; ABDOMINAL OBESITY; OXIDATIVE STRESS;
   INFLAMMATION; PREVALENCE; DYSFUNCTION
AB Hypoxia is a prominent characteristic of inflammatory tissue lesions. It can affect platelet function. While mean platelet volume (MPV) and platelet distribution width (PDW) are sample platelet indices, they may reflect subcinical platelet activation. To investigated associations between adiposity indices and platelet indices, 17327 eligible individuals (7677 males and 9650 females) from the Dongfeng-Tongji Cohort Study (DFTJ-Cohort Study, n=27009) were included in this study, except for 9682 individuals with missing data on demographical, lifestyle, physical indicators and diseases relative to PDW and MPV. Associations between adiposity indices including waist circumstance (WC), waist-to-height ratio (WHtR), body mass index (BMI), and MPV or PDW in the participants were analyzed using multiple logistic regressions. There were significantly negative associations between abnormal PDW and WC or WHtR for both sexes (p(trend)<0.001 for all), as well as abnormal MPV and WC or WHtR among female participants (p(trend)<0.05 for all). In the highest BMI groups, only females with low MPV or PDW were at greater risk for having low MPV (OR=1.33, 95% CI=1.10, 1.62 p(trend)<0.001) or PDW (OR=1.34, 95% CI=1.14, 1.58, p(trend)<0.001) than those who had low MPV or PDW in the corresponding lowest BMI group. The change of PDW seems more sensitive than MPV to oxidative stress and hypoxia. Associations between reduced PDW and MPV values and WC, WHtR and BMI values in Chinese female adults may help us to further investigate early changes in human body.
C1 [Hou, Jian; Liu, Chuanyao; Chen, Weihong; He, Meian; Xu, Tian; Wu, Tangchun; Yuan, Jing] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Dept Occupat & Environm Hlth, Wuhan 430030, Hubei, Peoples R China.
   [Hou, Jian; Liu, Chuanyao; Yao, Ping; Chen, Weihong; He, Meian; Wang, Youjie; Liang, Yuan; Xu, Tian; Wu, Tangchun; Yuan, Jing] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, MOE Key Lab Environm & Hlth, Wuhan 430030, Hubei, Peoples R China.
   [Yao, Ping] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Dept Nutr & Food Hyg, Wuhan 430030, Hubei, Peoples R China.
   [Wang, Youjie; Fang, Weimin] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Dept Maternal & Child Hlth, Wuhan 430030, Hubei, Peoples R China.
   [Liang, Yuan] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Dept Social Med & Hlth Management, Wuhan 430030, Hubei, Peoples R China.
   [Miao, Xiaoping; Wei, Sheng] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Dept Epidemiol & Biostat, Wuhan 430030, Hubei, Peoples R China.
   [Zhu, Jiang] Dongfeng Motor Corp, Dongfeng Cent Hosp, Phys Examinat Ctr, Shiyan 442008, Hubei, Peoples R China.
   [Li, Xiulou] Dongfeng Motor Corp, Dongfeng Cent Hosp, Dept Clin Teaching & Sci, Shiyan 442008, Hubei, Peoples R China.
   [Hu, Frank B.] Harvard Univ, Sch Publ Hlth, Dept Nutr & Epidemiol, Boston, MA 02115 USA.
   [Yang, Handong] Dongfeng Motor Corp, Dongfeng Cent Hosp, Dept Cardiol, Shiyan 442008, Hubei, Peoples R China.
C3 Huazhong University of Science & Technology; Huazhong University of
   Science & Technology; Huazhong University of Science & Technology;
   Huazhong University of Science & Technology; Huazhong University of
   Science & Technology; Huazhong University of Science & Technology;
   Dongfeng Motor; Dongfeng Motor; Harvard University; Harvard T.H. Chan
   School of Public Health; Dongfeng Motor
RP Yang, HD (corresponding author), Dongfeng Motor Corp, Dongfeng Cent Hosp, Dept Cardiol, Shiyan 442008, Hubei, Peoples R China.
EM yanghand@139.com; jyuan@tjh.tjmu.edu.cn
RI Hou, Jian/AAC-1400-2022; Hu, Frank/C-1919-2013; yu, ye/KVB-7532-2024;
   li, yan/GXH-7943-2022; wei, sheng/E-9746-2012; miao,
   xiaoping/C-4336-2011
OI Hou, Jian/0000-0002-8478-0416; miao, xiaoping/0000-0002-6818-9722
FU National Key Basic Research and Development Program [2011CB503800,
   2011CB5038004]; 111 Project [B12004]; Program for Changjiang Scholars;
   Innovative Research Team in University of Ministry of Education of China
   [IRT1246]; China Medical Board [12-113]; Dongfeng Motor Corporation
FX This work was supported by research funds from the National Key Basic
   Research and Development Program (2011CB503800, TC, Wu and
   2011CB5038004, WH, Chen); the 111 Project (No. B12004, TC, Wu); the
   Program for Changjiang Scholars (TC, Wu); Innovative Research Team in
   University of Ministry of Education of China (NO. IRT1246), China
   Medical Board (No. 12-113, TC, Wu). The funders had no role in study
   design, data collection and analysis, decision to publish, or
   preparation of the manuscript. Dongfeng Motor Corporation only provided
   support in the form of salaries for authors [J Zhu, XL Li, and HD Yang],
   but did not have any additional role in the study design, data
   collection and analysis, decision to publish, or preparation of the
   manuscript. The specific roles of these authors are articulated in the
   author contributions section.
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NR 43
TC 13
Z9 13
U1 0
U2 10
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JUN 9
PY 2015
VL 10
IS 6
AR e0129677
DI 10.1371/journal.pone.0129677
PG 13
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA CK6PC
UT WOS:000356349000069
PM 26058081
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU André, C
   Dinel, AL
   Ferreira, G
   Layé, S
   Castanon, N
AF Andre, Caroline
   Dinel, Anne-Laure
   Ferreira, Guillaume
   Laye, Sophie
   Castanon, Nathalie
TI Diet-induced obesity progressively alters cognition, anxiety-like
   behavior and lipopolysaccharide-induced depressive-like behavior: Focus
   on brain indoleamine 2,3-dioxygenase activation
SO BRAIN BEHAVIOR AND IMMUNITY
LA English
DT Article
DE Obesity; Inflammation; Hippocampus; Mice; Lipopolysaccharide; Cytokines;
   Indoleamine 2,3-dioxygenase; Anxiety; Depression; Spatial memory
ID BACILLE CALMETTE-GUERIN; METABOLIC SYNDROME; HIPPOCAMPAL NEUROGENESIS;
   INFLAMMATORY RESPONSE; IMMUNE ACTIVATION; UP-REGULATION; MOUSE MODEL;
   IN-VIVO; MICE; MEMORY
AB Obesity is associated with a high prevalence of mood symptoms and cognitive dysfunctions that emerges as significant risk factors for important health complications such as cardiovascular diseases and type 2 diabetes. It is therefore important to identify the dynamic of development and the pathophysiological mechanisms underlying these neuropsychiatric symptoms. Obesity is also associated with peripheral low-grade inflammation and increased susceptibility to immune-mediated diseases. Excessive production of proinflammatory cytokines and the resulting activation of the brain tryptophan catabolizing enzyme indoleamine 2,3-dioxygenase (IDO) have been shown to promote neurobehavioral complications, particularly depression. In that context, questions arise about the impact of diet-induced obesity on the onset of neuropsychiatric alterations and the increased susceptibility to immune-mediated diseases displayed by obese patients, particularly through brain IDO activation.
   To answer these questions, we used C57B1/6 mice exposed to standard diet or western diet (WD; consisting of palatable energy-dense food) since weaning and for 20 weeks. We then measured inflammatory and behavioral responses to a systemic immune challenge with lipopolysaccharide (LPS) in experimental conditions known to alter cognitive and emotional behaviors independently of any motor impairment. We first showed that in absence of LPS, 9 weeks of WD is sufficient to impair spatial recognition memory (in the Y-maze). On the other hand, 18 weeks of WD increased anxiety-like behavior (in the elevated plus-maze), but did not affect depressive-like behavior (in the tail-suspension and forced-swim tests). However, 20 weeks of WD altered LPS-induced depressive-like behavior compared to LPS-treated lean mice and exacerbated hippocampal and hypothalamic proinflammatory cytokine expression and brain IDO activation. Taken together, these results show that WD exposure alters cognition and anxiety in unstimulated conditions and enhances activation of neurobiological mechanisms underlying depression after immune stimulation. They suggest therefore that obesity, and possibly obesity-associated inflammatory priming, may represent a vulnerability state to immune-mediated depressive symptoms. (C) 2014 Elsevier Inc. All rights reserved.
C1 INRA, UMR 1286, F-33076 Bordeaux, France.
   Univ Bordeaux, UMR 1286, F-33076 Bordeaux, France.
C3 Universite de Bordeaux; INRAE; Institut National de la Sante et de la
   Recherche Medicale (Inserm); Universite de Bordeaux; Institut National
   de la Sante et de la Recherche Medicale (Inserm)
RP Castanon, N (corresponding author), Univ Victor Segalen, INRA, UMR 1286, Batiment UFR Pharm,2 Tranche,2 Etage, F-33076 Bordeaux, France.
EM nathalie.castanon@bordeaux.inra.fr
RI Laye, Sophie/AAX-2501-2020
OI Laye, Sophie/0000-0002-3843-1012; Ferreira,
   Guillaume/0000-0001-5984-8143; Castanon, Nathalie/0000-0002-0079-0562
FU Institut National de la Recherche Agronomique; Region Aquitaine;
   Institut Danone
FX This work was supported by the Institut National de la Recherche
   Agronomique and by the Region Aquitaine. A.L.D. was supported by a
   doctoral fellowship from the Institut Danone. The funders had no role in
   study design, data collection and analysis, decision to publish, or
   preparation of the manuscript.
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NR 84
TC 180
Z9 194
U1 1
U2 67
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0889-1591
EI 1090-2139
J9 BRAIN BEHAV IMMUN
JI Brain Behav. Immun.
PD OCT
PY 2014
VL 41
BP 10
EP 21
DI 10.1016/j.bbi.2014.03.012
PG 12
WC Immunology; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Neurosciences & Neurology; Psychiatry
GA AP2MD
UT WOS:000341905400002
PM 24681251
DA 2025-06-11
ER

PT J
AU Chiu, CJ
   Lin, YC
AF Chiu, Ching-Ju
   Lin, Yu-Cheng
TI Spousal health and older adults' biomarker change over six years:
   Investigation of gender differences
SO ARCHIVES OF GERONTOLOGY AND GERIATRICS
LA English
DT Article
DE Elders; Spousal health concordance; Biomarkers
ID PHYSICAL HEALTH; CARDIOVASCULAR-DISEASE; ALLOSTATIC LOAD; MENTAL-HEALTH;
   RISK; CONCORDANCE; COUPLES; STRESS; POPULATION; CAREGIVERS
AB Objective: Relationship of spousal health and biomarkers over six years were examined.
   Methods and materials: Nationally representative sample of 483 adults aged 54 + in Taiwan were followed for six years. Four classes of spousal health changes and three categories of biomarker indexes were examined. Biomarkers were assessed by counting the adverse progression on items of allostatic load (AL), cardiovascular disease biomarkers (CVD), and metabolic syndromes, respectively.
   Results: When the health status of an individual's spouse became worse, women increased their AL by 0.48 (P < 0.05), CVD by 0.56 (P < .001), and metabolic syndrome by 0.43 (P < 0.05). If the health status of a woman's spouse remained poor, it increased her allostatic load by 0.60 (P < 0.05). These effects were only observed in women. In addition, when the health status of a men's spouse became better, man's biomarker profile on AL significantly improved by 0.80 (P < 0.05). No significant moderating effect of education was observed in this sample.
   Conclusions: Married couples display concordance in both physical and mental health-related biomarkers, specifically, allostatic load. Women were more likely than men to experience adverse biomarker progress on all the biomarkers examined in this study when the status of their spouse became worse based on their subjective judgment, and men were more sensitive to positive health changes in their spouse than women.
C1 [Chiu, Ching-Ju; Lin, Yu-Cheng] Natl Cheng Kung Univ, Inst Gerontol, Coll Med, 1 Univ Rd, Tainan 70101, Taiwan.
C3 National Cheng Kung University
RP Chiu, CJ (corresponding author), Natl Cheng Kung Univ, Inst Gerontol, Coll Med, 1 Univ Rd, Tainan 70101, Taiwan.
EM cjchiu@mail.ncku.edu.tw
FU Research Center for Humanities and Social Sciences, National Cheng Kung
   University, Taiwan [H101-A304, FD101037]
FX This work was supported by grants from Research Center for Humanities
   and Social Sciences, National Cheng Kung University, Taiwan (H101-A304;
   FD101037).
CR [Anonymous], ENV HLTH PREVENTIVE
   [Anonymous], SPOUSAL CONCORDANCE
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NR 33
TC 12
Z9 13
U1 0
U2 8
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0167-4943
EI 1872-6976
J9 ARCH GERONTOL GERIAT
JI Arch. Gerontol. Geriatr.
PD JUL-AUG
PY 2019
VL 83
BP 44
EP 49
DI 10.1016/j.archger.2019.03.017
PG 6
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA IA1IS
UT WOS:000469313500008
PM 30947066
DA 2025-06-11
ER

PT J
AU Matsubayashi, K
   Kimura, Y
   Sakamoto, R
   Wada, T
   Ishimoto, Y
   Hirosaki, M
   Konno, A
   Chen, WL
   Ishine, M
   Kosaka, Y
   Wada, C
   Nakatsuka, M
   Otsuka, K
   Fujisawa, M
   Wang, HX
   Dai, QX
   Yang, AR
   Gao, JD
   Li, ZQ
   Qiao, HS
   Zhang, YS
   Ge, RL
   Okumiya, K
AF Matsubayashi, Kozo
   Kimura, Yumi
   Sakamoto, Ryota
   Wada, Taizo
   Ishimoto, Yasuko
   Hirosaki, Mayumi
   Konno, Akiko
   Chen, Wingling
   Ishine, Masayuki
   Kosaka, Yasuyuki
   Wada, Chizu
   Nakatsuka, Masahiro
   Otsuka, Kuniaki
   Fujisawa, Michiko
   Wang, Hongxing
   Dai, Qingxiang
   Yang, Airong
   Gao, Jidong
   Li, Zhanquan
   Qiao, Haisheng
   Zhang, Yongshou
   Ge, Ri Li
   Okumiya, Kiyohito
TI Comprehensive geriatric assessment of elderly highlanders in Qinghai,
   China I: Activities of daily living, quality of life and metabolic
   syndrome
SO GERIATRICS & GERONTOLOGY INTERNATIONAL
LA English
DT Article
DE activities of daily living; elderly highlanders; metabolic syndrome;
   Qinghai Plateau in China; quality of life
ID PEOPLE; PREVALENCE
AB Aim:
   To reveal the comparison of comprehensive geriatric functions of elderly highlanders in Qinghai Plateau in China among three different ethnic groups.
   Methods:
   Activities of daily living (ADL), screening-based depression, quality of life (QOL) and checking-up of metabolic syndrome including community-based oral glucose tolerance test were assessed in 393 community-dwelling elderly subjects aged 60 years or more (247 Han elderly subjects, 49 Mongolian ones and 97 Tibetan ones).
   Results:
   Tibetan elderly highlanders were more disabled in ADL, but had higher QOL than Han elderly ones in Qinghai Plateau. Blood pressure measurements, rate of hypertension and hemoglobin concentrations in Tibetan elderly highlanders were lower than Han ones. Rates of diabetes and impaired glucose tolerance in elderly highlanders were relatively lower than other Asian elderly lowlanders.
   Conclusion:
   Prevalence of metabolic syndrome in elderly highlanders in Qinghai was still not high, however, we should pay attention to its tendency related with socialglobalism in the near future. Further investigation on physiological adaptability to hypoxic environment and human ageing phenomena in a global context may open a new research frontier for ageing science.
C1 [Matsubayashi, Kozo] Kyoto Univ, Ctr SE Asian Studies, Sakyoku ku, Kyoto 6068501, Japan.
   [Matsubayashi, Kozo; Kimura, Yumi; Ishimoto, Yasuko; Hirosaki, Mayumi; Konno, Akiko; Chen, Wingling] Kyoto Univ, Sch Publ Hlth, Kyoto 6068501, Japan.
   [Sakamoto, Ryota; Ishine, Masayuki; Kosaka, Yasuyuki; Wada, Chizu; Okumiya, Kiyohito] Kyoto Univ, Res Inst Humanity & Nat, Kyoto 6068501, Japan.
   [Nakatsuka, Masahiro] Kyoto Univ, Human Brain Res Ctr, Kyoto 6068501, Japan.
   [Otsuka, Kuniaki] Tokyo Womens Med Sch, Med Ctr W, Tokyo, Japan.
   [Fujisawa, Michiko] Kyoto Univ, Wildlife Res Ctr, Kyoto 6068501, Japan.
   [Wang, Hongxing; Dai, Qingxiang; Yang, Airong; Gao, Jidong; Li, Zhanquan] Qinghai Univ, Affiliated Hosp, Qinghai, Peoples R China.
   [Ge, Ri Li] Qinghai Univ, Res Ctr High Altitude Med, Qinghai, Peoples R China.
C3 Kyoto University; Kyoto University; Kyoto University; Research Institute
   for Humanity & Nature (RIHN); Kyoto University; Tokyo Women's Medical
   University; Kyoto University; Qinghai University; Qinghai University
RP Matsubayashi, K (corresponding author), Kyoto Univ, Ctr SE Asian Studies, Sakyoku ku, 46 Shimoadachi Cho, Kyoto 6068501, Japan.
EM kmatsu@cseas.kyoto-u.ac.jp
RI HIROSAKI, Mayumi/HCH-1388-2022; SAKAMOTO, Ryota/HCH-0846-2022; OKUMIYA,
   Kiyohito/HCH-0681-2022; FUJISAWA, Michiko/HCH-1050-2022
OI Sakamoto, Ryota/0000-0002-0774-9925
FU Research Institute of Humanity and Nature; Human Life, Aging, and
   Disease in High-Altitude Environments; JSPS Global COE Program [E-04]
FX We appreciate all of the elderly highlanders who participated in the
   community-based geriatric examination in Haiyan County in Qinghai
   Province. We would also like to express our cordial gratitude to the
   young staff of the Medical Institute of Qinghai University and all the
   staff of Haiyan Hospital who kindly helped us. We appreciate Yukiko Kita
   who supported the study. This study was mainly supported by a
   Grant-in-Aid of Research Institute of Humanity and Nature (3-4 FR):
   Human Life, Aging, and Disease in High-Altitude Environments:
   Physio-medical, Ecological and Cultural Adaptation in "Highland
   Civilization." (Leader: Okumiya Kihohito) and also partly supported by
   the Grant-in-Aid of the JSPS Global COE Program (E-04): In Search of
   Sustainable Humanosphere in Asia and Africa.
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NR 35
TC 15
Z9 16
U1 0
U2 17
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1444-1586
EI 1447-0594
J9 GERIATR GERONTOL INT
JI Geriatr. Gerontol. Int.
PD DEC
PY 2009
VL 9
IS 4
BP 333
EP 341
DI 10.1111/j.1447-0594.2009.00548.x
PG 9
WC Geriatrics & Gerontology; Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA 524FK
UT WOS:000272129000001
PM 20002752
DA 2025-06-11
ER

PT J
AU Jung, J
   Choo, J
   Park, S
   Moon, J
   Noh, S
AF Jung, Jiyeon
   Choo, Jina
   Park, Sooyeon
   Moon, Jihyun
   Noh, Songwhi
TI Job Stress and Cardiometabolic Lifestyle Modification Behaviors Among
   Workers in High-risk and Low-risk Workplaces
SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
LA English
DT Article
DE cardiovascular disease; health behavior; job stress; workers; workplace
ID CARDIOVASCULAR-DISEASES; OCCUPATIONAL STRESS; PSYCHOSOCIAL STRESS;
   REDUCTION PROGRAM; HEALTH; EMPLOYEES; DEMANDS; STRAIN; IMPACT
AB Objective: There is scarce evidence revealing an association between job stress and cardiometabolic lifestyle modification behaviors among workers. Methods: A cross-sectional, correlation study was conducted among workers in high-risk and low-risk workplaces by work characteristics. Results: Workers in high-risk workplaces had significantly higher job stress levels than low-risk workplaces. Higher job stress was significantly associated with lower cardiometabolic lifestyle modification behaviors (beta = -0.14, P = .001). This significant association was evident only for high-risk workplaces in total job stress (beta = -0.16, P = .001), including job demand (beta = -0.16, P = .005) and job insecurity (beta = -0.11, P = .026). Conclusions: Strategies for alleviating job stress should be prioritized to high-risk workplaces, and these efforts may concomitantly contribute to cardiometabolic risk reduction.
C1 [Jung, Jiyeon; Choo, Jina; Park, Sooyeon; Moon, Jihyun; Noh, Songwhi] Korea Univ, Coll Nursing, Seoul, South Korea.
   [Choo, Jina] Korea Univ, Grad Sch, Transdisciplinary Major Learning Hlth Syst, Seoul, South Korea.
C3 Korea University; Korea University
RP Choo, J (corresponding author), Korea Univ, Coll Nursing, Community Hlth Nursing, Seoul 02841, South Korea.
EM jinachoo@korea.ac.kr
RI Jung, Jiyeon/AAD-7727-2021
OI noh, songwhi/0000-0002-0533-5374; Jung, Jiyeon/0000-0002-8295-3424;
   Park, Sooyeon/0000-0003-0456-974X
FU Incheon Metropolitan Office of the Korea Occupational Safety and Health
   Agency (KOSHA); National Research Foundation of Korea (NRF) - Korea
   government [NRF2019R1A2C1004116]
FX This work has been supported by the Incheon Metropolitan Office of the
   Korea Occupational Safety and Health Agency (KOSHA) and the National
   Research Foundation of Korea (NRF) grant by the Korea government (No.
   NRF2019R1A2C1004116).
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NR 51
TC 1
Z9 1
U1 0
U2 11
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1076-2752
EI 1536-5948
J9 J OCCUP ENVIRON MED
JI J. Occup. Environ. Med.
PD JUN
PY 2021
VL 63
IS 6
BP E346
EP E351
DI 10.1097/JOM.0000000000002213
PG 6
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA TT6CC
UT WOS:000680433600009
PM 33950038
DA 2025-06-11
ER

PT J
AU Moreira, FP
   Jansen, K
   Mondin, TC
   Cardoso, TD
   Magalhaes, PVD
   Kapczinski, F
   Frey, BN
   Oses, JP
   Souza, LDD
   da Silva, RA
   Wiener, CD
AF Moreira, Fernanda Pedrotti
   Jansen, Karen
   Mondin, Thaise Campos
   Cardoso, Taiane de Azevedo
   da Silva Magalhaes, Pedro Vieira
   Kapczinski, Flavio
   Frey, Benicio N.
   Oses, Jean Pierre
   de Mattos Souza, Luciano Dias
   da Silva, Ricardo Azevedo
   Wiener, Carolina David
TI Biological rhythms, metabolic syndrome and current depressive episode in
   a community sample
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE Depression; Biological rhythm; Metabolic syndrome
ID SLEEP DURATION; LIPID-PEROXIDATION; CIRCADIAN-RHYTHMS; LEPTIN LEVELS;
   METAANALYSIS; DISORDERS; BIPOLAR; ABNORMALITIES; ASSOCIATION;
   DISTURBANCE
AB The purpose of this study was to assess the disruption in biological rhythms and metabolic syndrome (MetS) in individuals with depressive episode. This was a cross-sectional, population-based study with a representative sample of 905 young adults. Current depressive episode were confirmed by a psychologist using the Mini International Neuropsychiatric Interview (MINI) Plus. Self-reported biological rhythms were assessed using the Biological Rhythms Interview of Assessment in Neuropsychiatry (BRIAN). MetS was defined using modified NCEP/ATPIII criteria. Significant main effects of current depressive episode (p < 0.001,eta(2) = 0.163) and MetS (p = 0.001,eta(2) = 0.011) were observed on total BRIAN score. There was a significant interaction between depression and MetS in total biological rhythm scores (p = 0.002,eta(2) = 0.011) as well as sleep (p = 0.001,eta(2)= 0.016) and social domains (p < 0.001, eta(2) = 0.014). In the depressive group, subjects with MetS had a higher disruption in total BRIAN scores (p = 0.010), sleep domain (p = 0.004), social domain (p = 0.005) and in the eating pattern domain approached the level of significance (p = 0.098), when compared to subjects with no MetS. The results of the present study showed that self-reported disruptions in biological rhythms are associated with key components of the MetS in community adults with MDD. The understanding of the complex interactions between biological rhythms, MetS and depression are important in the development of preventive and therapeutic strategies. (C) 2016 Elsevier Ltd. All rights reserved.
C1 [Moreira, Fernanda Pedrotti; Jansen, Karen; Mondin, Thaise Campos; Cardoso, Taiane de Azevedo; Oses, Jean Pierre; de Mattos Souza, Luciano Dias; da Silva, Ricardo Azevedo; Wiener, Carolina David] Univ Catolica Pelotas, Postgrad Program Hlth & Behav, Pelotas, RS, Brazil.
   [da Silva Magalhaes, Pedro Vieira; Kapczinski, Flavio] Univ Fed Rio Grande do Sul, Dept Psychiat & Forens Med, BR-90046900 Porto Alegre, RS, Brazil.
   [Frey, Benicio N.] McMaster Univ, Dept Psychiat & Behav Neurosci, Hamilton, ON, Canada.
C3 Universidade Federal de Pelotas; Universidade Catolica de Pelotas;
   Universidade Federal do Rio Grande do Sul; McMaster University
RP Jansen, K (corresponding author), Rua Goncalves Chaves 373, BR-96015560 Ctr Pelotas, RS, Brazil.
EM karenjansen@pq.cnpq.br
RI Oses, Jean/E-2534-2013; Cardoso, Taiane/K-1980-2015; Pedrotti Moreira,
   Fernanda/JRX-8306-2023; Frey, Benicio/AAJ-8212-2021; Magalhaes,
   Pedro/A-8519-2008; Kapczinski, Flavio/D-3175-2013; Jansen,
   Karen/O-3128-2015
OI Oses, Jean Pierre/0000-0002-2012-273X; Magalhaes,
   Pedro/0000-0002-5644-6357; Pedrotti Moreira,
   Fernanda/0000-0002-3672-7231; Kapczinski, Flavio/0000-0001-8738-856X;
   Jansen, Karen/0000-0003-3494-8070; Frey, Benicio N./0000-0001-8267-943X
FU Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES);
   Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq);
   Fundacao de Amparo a Pesquisa do Estado do Rio Grande do Sul (FAPERGS)
FX The research was funded by a grant from the Brazilian governmental
   agencies: Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior
   (CAPES), Conselho Nacional de Desenvolvimento Cientifico e Tecnologico
   (CNPq) and Fundacao de Amparo a Pesquisa do Estado do Rio Grande do Sul
   (FAPERGS). The agencies had no further role in study design; in the
   collection, analysis and interpretation of data; in the writing of the
   report; or in the decision to submit the paper for publication.
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NR 44
TC 18
Z9 18
U1 1
U2 9
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD OCT
PY 2016
VL 72
BP 34
EP 39
DI 10.1016/j.psyneuen.2016.06.007
PG 6
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA DV0FY
UT WOS:000382594600004
PM 27343724
DA 2025-06-11
ER

PT J
AU Catrysse, L
   van Loo, G
AF Catrysse, Leen
   van Loo, Geert
TI Inflammation and the Metabolic Syndrome: The Tissue-Specific Functions
   of NF-κB
SO TRENDS IN CELL BIOLOGY
LA English
DT Review
ID INDUCED INSULIN-RESISTANCE; PANCREATIC BETA-CELLS; DIET-INDUCED OBESITY;
   ENDOPLASMIC-RETICULUM STRESS; UNFOLDED PROTEIN RESPONSE; FATTY
   LIVER-DISEASE; IKK-BETA; ADIPOSE-TISSUE; GLUCOSE-INTOLERANCE;
   HEPATOCELLULAR-CARCINOMA
AB Obesity is becoming a major health concern in Western society, and medical conditions associated with obesity are grouped in the metabolic syndrome. Overnutrition activates several proinflammatory signaling pathways, leading to a condition of chronic low-grade inflammation in several metabolic tissues affecting their proper function. Nuclear factor kappa B (NF-kappa B) signaling is a crucial pathway in this process and has been studied extensively in the context of obesity and the metabolic syndrome. Here we give an overview of the molecular mechanisms behind the inflammatory function of NF-kappa B in response to overnutrition and the effect this has on several metabolic tissues.
C1 [Catrysse, Leen; van Loo, Geert] VIB Ctr Inflammat Res, B-9052 Ghent, Belgium.
   [Catrysse, Leen; van Loo, Geert] Univ Ghent, Dept Biomed Mol Biol, B-9052 Ghent, Belgium.
C3 Ghent University; Flanders Institute for Biotechnology (VIB); Ghent
   University
RP van Loo, G (corresponding author), VIB Ctr Inflammat Res, B-9052 Ghent, Belgium.; van Loo, G (corresponding author), Univ Ghent, Dept Biomed Mol Biol, B-9052 Ghent, Belgium.
EM geert.vanloo@irc.vib-ugent.be
RI van Loo, Geert/JPA-2609-2023
OI Geert, van Loo/0000-0002-8427-4775
FU Instituut voor Innovatie door Wetenschap en Technologie (IWT); Kom op
   tegen Kanker; FWO; Belgian Foundation against Cancer; Geneeskundige
   Stichting Koningin Elisabeth (GSKE); Charcot Foundation; Interuniversity
   Attraction Poles program (IAP7); Concerted Research Actions (GOA);
   Group-ID MRP of Ghent University
FX L.C. was supported as a PhD fellow by the Instituut voor Innovatie door
   Wetenschap en Technologie (IWT) and by a research grant from Kom op
   tegen Kanker. Research in the van Loo laboratory was also supported by
   research grants from the FWO, the Belgian Foundation against Cancer, the
   Geneeskundige Stichting Koningin Elisabeth (GSKE), the Charcot
   Foundation, the Interuniversity Attraction Poles program (IAP7), and
   Concerted Research Actions (GOA) and Group-ID MRP of Ghent University.
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NR 97
TC 237
Z9 260
U1 2
U2 42
PU ELSEVIER SCIENCE LONDON
PI LONDON
PA 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND
SN 0962-8924
EI 1879-3088
J9 TRENDS CELL BIOL
JI Trends Cell Biol.
PD JUN
PY 2017
VL 27
IS 6
BP 417
EP 429
DI 10.1016/j.tcb.2017.01.006
PG 13
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA EV1NQ
UT WOS:000401513600004
PM 28237661
DA 2025-06-11
ER

PT J
AU Perez-Cornago, A
   de la Iglesia, R
   Lopez-Legarrea, P
   Abete, I
   Navas-Carretero, S
   Lacunza, CI
   Lahortiga, F
   Martinez-Gonzalez, MA
   Martinez, JA
   Zulet, MA
AF Perez-Cornago, Aurora
   de la Iglesia, Rocio
   Lopez-Legarrea, Patricia
   Abete, Itziar
   Navas-Carretero, Santiago
   Lacunza, Clara I.
   Lahortiga, Francisca
   Martinez-Gonzalez, Miguel A.
   Alfredo Martinez, J.
   Angeles Zulet, M.
TI A decline in inflammation is associated with less depressive symptoms
   after a dietary intervention in metabolic syndrome patients: a
   longitudinal study
SO NUTRITION JOURNAL
LA English
DT Article
DE Metabolic syndrome; Depression; Inflammation; Leptin; Hypocaloric diet;
   Adiposity
ID WEIGHT-LOSS; CARDIOVASCULAR-DISEASE; PHYSICAL-ACTIVITY; OBESITY; LEPTIN;
   WOMEN; DISORDERS; REDUCTION; NUTRITION; PATTERN
AB Background: Metabolic syndrome (MetS) and depression have become two prevalent diseases worldwide, whose interaction needs further investigation. Dietary treatment for weight loss in patients with MetS may improve depressive manifestations, however, the precise interactive pathways remain uncertain. Therefore, the aim of this study was to examine the effects of a hypocaloric diet designed to reduce MetS features on self-perceived depression and the possible underlying factors.
   Methods: Sixty subjects (Age: 50 +/- 1 y; BMI: 36.1 +/- 0.6 kg/m(2)) with MetS were selected from the RESMENA study (control and intervention) after they completed the 6-months hypocaloric treatment and rated for depressive symptoms using the Beck Depression Inventory (BDI). Anthropometric and biochemical measurements including leptin, C-reactive protein (CRP) and insulin levels were evaluated.
   Results: Depressive symptoms decreased during the weight loss intervention, with no differences between both dietary groups (control group -4.2 +/- 0.8 vs RESMENA group -3.2 +/- 0.6, P = 0.490). The number of criteria of the MetS was higher among subjects with more somatic-related depressive symptoms at baseline (B = 1.032, P-trend = 0.017). After six months of dietary treatment, body weight decreased in all subjects (-8.7%; confidence interval (95% CI) = 7.0-9.7) and also self-perceived depression (-37.9%; 95% CI = 2.7-4.9), as well as circulating leptin (-20.1%; 95% CI = 1.8-6.8), CRP (-42.8%; 95% CI = 0.6-3.0) and insulin (-37.7%; 95% CI = 4.1-7.2) concentrations. The decrease in BDI was significantly associated with declines in body fat mass (B = 0.34, 95% CI = 0.11-0.56) and also with the decrease in leptin (B = 0.16, 95% CI = 0.04-0.28) and CRP (B = 0.24, 95% CI = 0.01-0.46) concentrations.
   Conclusions: The decrease in depressive manifestations after a weight loss intervention was related with adiposity, CRP and leptin in subjects with MetS.
C1 [Perez-Cornago, Aurora; de la Iglesia, Rocio; Lopez-Legarrea, Patricia; Navas-Carretero, Santiago; Alfredo Martinez, J.; Angeles Zulet, M.] Univ Navarra, Dept Nutr Food Sci & Physiol, Pamplona 31008, Spain.
   [Lopez-Legarrea, Patricia] Univ Autonoma Chile, Fac Hlth Sci, Santiago, Chile.
   [Abete, Itziar] Biodonostia Hlth Res Inst, San Sebastian 20014, Spain.
   [Navas-Carretero, Santiago; Alfredo Martinez, J.; Angeles Zulet, M.] CIBERobn, Carlos Hlth Res Inst 3, Madrid, Spain.
   [Lacunza, Clara I.; Lahortiga, Francisca] Univ Navarra Clin, Dept Psychiat & Med Psychol, Pamplona 31008, Spain.
   [Martinez-Gonzalez, Miguel A.] Univ Navarra, Dept Prevent Med & Publ Hlth, Pamplona 31008, Spain.
C3 University of Navarra; Universidad Autonoma de Chile; Instituto de
   Investigacion Sanitaria Biogipuzkoa; CIBER - Centro de Investigacion
   Biomedica en Red; CIBEROBN; University of Navarra; University of Navarra
RP Martinez, JA (corresponding author), Univ Navarra, Dept Nutr Food Sci & Physiol, Irunlarrea 1, Pamplona 31008, Spain.
EM jalfmtz@unav.es
RI Martinez-Gonzalez, Miguel/AAE-7669-2019; de la Iglesia,
   Rocio/ABC-6189-2020; Perez-Cornago, Aurora/C-1097-2016; Lahortiga-Ramos,
   Francisca/H-9363-2017; Navas-Carretero, Santiago/L-2918-2015; Abete,
   Itziar/H-4827-2017; Martinez Hernandez, J Alfredo/K-8709-2014; Zulet, M.
   Angeles/H-1317-2017
OI Martinez-Gonzalez, Miguel A./0000-0002-3917-9808; Perez-Cornago,
   Aurora/0000-0002-5652-356X; Lahortiga-Ramos,
   Francisca/0000-0001-7624-6902; de la Iglesia, Rocio/0000-0002-7472-3565;
   Navas-Carretero, Santiago/0000-0002-5163-2230; Abete,
   Itziar/0000-0002-6475-5387; Martinez Hernandez, J
   Alfredo/0000-0001-5218-6941; Zulet, M. Angeles/0000-0002-3926-0892
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NR 41
TC 29
Z9 30
U1 0
U2 14
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1475-2891
J9 NUTR J
JI Nutr. J.
PD APR 24
PY 2014
VL 13
AR 36
DI 10.1186/1475-2891-13-36
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA AG6KD
UT WOS:000335526600001
PM 24762259
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Melo, DD
   Pereira, LC
   Santos, CS
   Mendes, BF
   Konig, IFM
   Garcia, BCC
   Queiroz, IP
   Moreno, LG
   Cassilhas, RC
   Esteves, EA
   Vieira, ER
   Magalhaes, FD
   Capettini, LDA
   De Sousa, RAL
   Sampaio, KH
   Peixoto, MFD
AF Melo, Dirceu de Sousa
   Pereira, Liliane Costa
   Santos, Carina Sousa
   Mendes, Bruno Ferreira
   Konig, Isaac Filipe Moreira
   Garcia, Bruna Caroline Chaves
   Queiroz, Ilkilene Pinheiro
   Moreno, Lauane Gomes
   Cassilhas, Ricardo Cardoso
   Esteves, Elizabethe Adriana
   Vieira, Etel Rocha
   Magalhaes, Flavio de Castro
   Capettini, Luciano dos Santos Aggum
   De Sousa, Ricardo Augusto Leoni
   Sampaio, Kinulpe Honorato
   Peixoto, Marco Fabricio Dias
TI Intense Caloric Restriction from Birth Prevents Cardiovascular Aging in
   Rats
SO REJUVENATION RESEARCH
LA English
DT Article
DE diet; food restriction; cardiovascular diseases; elderly; senescence
ID DIASTOLIC DYSFUNCTION; REDOX HOMEOSTASIS; OXIDATIVE STRESS; PLASMA;
   DAMAGE
AB We previously demonstrated that a 50% caloric restriction (CR) from birth improves several cardiometabolic risk factors in young rats. In this study, we investigated in middle-aged rats the consequences of a 50% CR from birth on cardiometabolic risk factors, heart function/morphology, ventricular arrhythmia, and fibrillation incidence, and cardiac intracellular proteins involved with redox status and cell survival. From birth to the age of 18 months, rats were divided into an Ad Libitum (AL18) group, which had free access to food, and a CR18 group, which had food limited to 50% of that consumed by the AL18. Resting metabolic rate, blood pressure, and heart rate were recorded, and oral glucose and intraperitoneal insulin tolerance tests were performed. Blood was collected for biochemical analyses, and visceral fat and liver were harvested and weighed. Hearts were harvested for cardiac function, histological, redox status, and western blot analyses. The 50% CR from birth potentially reduced several cardiometabolic risk factors in 18-month-old rats. Moreover, compared with AL18, the CR18 group showed a similar to 50% increase in cardiac contractility and relaxation, nearly three to five times less incidence of ventricular arrhythmia and fibrillation, similar to 18% lower cardiomyocyte diameter, and similar to 60% lower cardiac fibrosis. CR18 hearts also improved biomarkers of antioxidant defense and cell survival. Collectively, these results reveal several metabolic and cardiac antiaging effects of a 50% CR from birth in middle-aged rats.
C1 [Melo, Dirceu de Sousa; Pereira, Liliane Costa; Santos, Carina Sousa; Mendes, Bruno Ferreira; Garcia, Bruna Caroline Chaves; Moreno, Lauane Gomes; Cassilhas, Ricardo Cardoso; Esteves, Elizabethe Adriana; Vieira, Etel Rocha; Magalhaes, Flavio de Castro; De Sousa, Ricardo Augusto Leoni; Sampaio, Kinulpe Honorato; Peixoto, Marco Fabricio Dias] Univ Fed Vales Jequitinhonha & Mucuri UFVJM, Programa Posgrad Multicentr Ciencias Fisiol, Rodovia MGT 367,Km 583, BR-39100000 Diamantina, Brazil.
   [Konig, Isaac Filipe Moreira] Univ Fed Lavras UFLA, Dept Med Vet, Lavras, Brazil.
   [Queiroz, Ilkilene Pinheiro; Cassilhas, Ricardo Cardoso; Esteves, Elizabethe Adriana; Vieira, Etel Rocha; Magalhaes, Flavio de Castro; Sampaio, Kinulpe Honorato; Peixoto, Marco Fabricio Dias] Univ Fed Vales Jequitinhonha & Mucuri UFVJM, Programa Posgrad Ciencias Saude, Diamantina, Brazil.
   [Capettini, Luciano dos Santos Aggum] Univ Fed Minas Gerais UFMG, Programa Posgrad Fisiol & Farmacol, Belo Horizonte, Brazil.
C3 Universidade Federal dos Vales do Jequitinhonha e Mucuri (UFVJM);
   Universidade Federal de Lavras; Universidade Federal dos Vales do
   Jequitinhonha e Mucuri (UFVJM); Universidade Federal de Minas Gerais
RP Peixoto, MFD (corresponding author), Univ Fed Vales Jequitinhonha & Mucuri UFVJM, Programa Posgrad Multicentr Ciencias Fisiol, Rodovia MGT 367,Km 583, BR-39100000 Diamantina, Brazil.
EM marcofabri@ufvjm.edu.br
RI Konig, Isaac/JBJ-6266-2023; Honorato-Sampaio, Kinulpe/ACC-5742-2022;
   Fabricio Dias Peixoto, Marco/IWE-4695-2023; De Sousa,
   Ricardo/AAR-4540-2021; Esteves, Elizabethe/AAX-2455-2021; Rocha-Vieira,
   Etel/A-2524-2017; de Castro Magalhaes, Flavio/AAB-5540-2022; C.
   Cassilhas, Ricardo/E-5920-2012
OI de Castro Magalhaes, Flavio/0000-0002-1963-982X; C. Cassilhas,
   Ricardo/0000-0001-6970-2551; Esteves, Elizabethe
   Adriana/0000-0003-1435-8364
FU Fundacao de Amparo a Pesquisa do Estado de Minas Gerais (FAPEMIG)
   [APQ-00214-21, APQ-01049-21, APQ-00938-18, APQ-03855-16]; Conselho
   Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
   [438498/2018-6]; Coordenacao de Aperfeicoamento de Pessoal de Nivel
   Superior (CAPES) [001]
FX We thank the Centro Integrado de Pos-Graduacao e Pesquisa em Saude,
   (CIPq-Saude) from the Universidade Federal dos Vales do Jequitinhonha e
   Mucuri (UFVJM) for providing equipment and technical support for
   experiments. We thank the Fundacao de Amparo a Pesquisa do Estado de
   Minas Gerais (FAPEMIG) (Nos. APQ-00214-21, APQ-01049-21, APQ-00938-18,
   APQ-03855-16), Conselho Nacional de Desenvolvimento Cientifico e
   Tecnologico (CNPq) (No. 438498/2018-6), and Coordenacao de
   Aperfeicoamento de Pessoal de Nivel Superior (CAPES)-Finance code 001
   for providing financial support.
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NR 48
TC 2
Z9 2
U1 0
U2 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1549-1684
EI 1557-8577
J9 REJUV RES
JI Rejuv. Res.
PD OCT 1
PY 2023
VL 26
IS 5
BP 194
EP 205
DI 10.1089/rej.2023.0032
PG 12
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA U5PU5
UT WOS:001085330300003
PM 37694594
DA 2025-06-11
ER

PT J
AU López-Baltanás, R
   Rodríguez-Ortiz, ME
   Díaz-Tocados, JM
   Martinez-Moreno, JM
   Membrives, C
   Rodelo-Haad, C
   de Mier, MVPR
   Rodríguez, M
   Canalejo, A
   Almadén, Y
   Muñoz-Castañeda, JR
AF Lopez-Baltanas, Rodrigo
   Rodriguez-Ortiz, Maria E.
   Diaz-Tocados, Juan M.
   Martinez-Moreno, Julio M.
   Membrives, Cristina
   Rodelo-Haad, Cristian
   Ruiz de Mier, M. Victoria Pendon
   Rodriguez, Mariano
   Canalejo, Antonio
   Almaden, Yolanda
   Munoz-Castaneda, Juan R.
TI Dietary Mg Supplementation Decreases Oxidative Stress, Inflammation, and
   Vascular Dysfunction in an Experimental Model of Metabolic Syndrome with
   Renal Failure
SO ANTIOXIDANTS
LA English
DT Article
DE magnesium; metabolic syndrome; chronic kidney disease; inflammation;
   oxidative stress; vascular dysfunction
ID CHRONIC KIDNEY-DISEASE; GLUTATHIONE-PEROXIDASE; CARDIOVASCULAR-DISEASE;
   CYSTATIN-C; MAGNESIUM; RISK; METAANALYSIS; KLOTHO; PROGRESSION;
   PREVENTION
AB Background: Metabolic syndrome (MetS) and chronic kidney disease (CKD) are commonly associated with cardiovascular disease (CVD) and in these patients Mg concentration is usually decreased. This study evaluated whether a dietary Mg supplementation might attenuate vascular dysfunction through the modulation of oxidative stress and inflammation in concurrent MetS and CKD. Methods: A rat model of MetS (Zucker strain) with CKD (5/6 nephrectomy, Nx) was used. Nephrectomized animals were fed a normal 0.1%Mg (MetS+Nx+Mg0.1%) or a supplemented 0.6%Mg (MetS+Nx+Mg0.6%) diet; Sham-operated rats with MetS receiving 0.1%Mg were used as controls. Results: As compared to controls, the MetS+Nx-Mg0.1% group showed a significant increase in oxidative stress and inflammation biomarkers (lipid peroxidation and aortic interleukin-1b and -6 expression) and Endothelin-1 levels, a decrease in nitric oxide and a worsening in uremia and MetS associated pathology as hypertension, and abnormal glucose and lipid profile. Moreover, proteomic evaluation revealed changes mainly related to lipid metabolism and CVD markers. By contrast, in the MetS+Nx+Mg0.6% group, these parameters remained largely similar to controls. Conclusion: In concurrent MetS and CKD, dietary Mg supplementation reduced inflammation and oxidative stress and improved vascular function.
C1 [Lopez-Baltanas, Rodrigo; Rodriguez-Ortiz, Maria E.; Martinez-Moreno, Julio M.; Membrives, Cristina; Almaden, Yolanda] Univ Cordoba, Reina Sofia Univ Hosp, Inst Maimonides Invest Biomed Cordoba IMIB, Cordoba 14004, Spain.
   [Rodriguez-Ortiz, Maria E.; Rodelo-Haad, Cristian; Ruiz de Mier, M. Victoria Pendon; Rodriguez, Mariano; Munoz-Castaneda, Juan R.] Inst Salud Carlos III, Redes Invest Cooperat Orientadas Resultados Salud, Madrid 28029, Spain.
   [Diaz-Tocados, Juan M.] Arnau de Vilanova Univ Hosp, Biomed Res Inst Lleida IRBLleida, Vasc & Renal Translat Res Grp, Lleida 25198, Spain.
   [Rodelo-Haad, Cristian; Ruiz de Mier, M. Victoria Pendon; Rodriguez, Mariano; Munoz-Castaneda, Juan R.] Univ Cordoba, Reina Sofia Univ Hosp, Un Gest Clin Nefrol, Inst Maimonides Invest Biomed Cordoba IMIB, Cordoba 14004, Spain.
   [Canalejo, Antonio] Univ Huelva, Res Ctr Nat Resources Hlth & Environm RENSMA, Dept Integrated Sci, Huelva 21007, Spain.
C3 Universidad de Cordoba; Instituto de Salud Carlos III; Universidad de
   Cordoba; Universidad de Huelva
RP Canalejo, A (corresponding author), Univ Huelva, Res Ctr Nat Resources Hlth & Environm RENSMA, Dept Integrated Sci, Huelva 21007, Spain.
EM antonio.canalejo@dbasp.uhu.es
RI Martínez, Julio/AAA-6724-2020; Muñoz-Castañeda, Juan/AFQ-3443-2022; Díaz
   Tocados, Juan/I-8254-2018; Rodriguez-Ortiz, Maria
   Encarnacion/B-2871-2019; Canalejo Raya, Antonio/L-8407-2014
OI Munoz-Castaneda, Juan R/0000-0002-9341-0724; Martinez,
   Julio/0000-0002-1945-5078; Rodriguez-Ortiz, Maria
   Encarnacion/0000-0002-3696-582X; Diaz Tocados, Juan
   Miguel/0000-0001-5192-5212; Lopez Baltanas, Rodrigo/0000-0003-2598-7182;
   Canalejo Raya, Antonio/0000-0003-2098-8960
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NR 63
TC 7
Z9 7
U1 2
U2 16
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD FEB
PY 2023
VL 12
IS 2
AR 283
DI 10.3390/antiox12020283
PG 20
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA 9G2PF
UT WOS:000938000300001
PM 36829843
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Gurka, MJ
   Vishnu, A
   Okereke, OI
   Musani, S
   Sims, M
   DeBoer, MD
AF Gurka, Matthew J.
   Vishnu, Abhishek
   Okereke, Olivia I.
   Musani, Solomon
   Sims, Mario
   DeBoer, Mark D.
TI Depressive symptoms are associated with worsened severity of the
   metabolic syndrome in African American women independent of lifestyle
   factors: A consideration of mechanistic links from the Jackson heart
   study
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE Depression; Metabolic syndrome; Risk
ID UNITED-STATES; CARDIOVASCULAR-DISEASE; MENTAL-DISORDERS; US POPULATION;
   HIGH-RISK; PREVALENCE; HEALTH; ADULTS; INFLAMMATION; BLACKS
AB Background: Depression and the metabolic syndrome (MetS) are both risk factors for cardiovascular disease and type 2 diabetes mellitus. Prior studies in predominantly White populations demonstrated that individuals with depressive symptoms at baseline are more likely to develop future MetS. We tested the hypothesis that depressive symptoms would contribute to a more pronounced increase in MetS severity among African Americans in the Jackson Heart Study (JHS).
   Methods: We used repeated-measures modeling among 1743 JHS participants during Visits 1-3 over 8 years of follow-up to evaluate relations between depressive symptom score (Center for Epidemiologic Survey-Depression (CES-D)) at baseline and a sex- and race/ethnicity-specific MetS severity Z-score at each visit.
   Results: 20.3% of participants had a CES-D score >= 16, consistent with clinically-relevant depressive symptoms. Higher depressive-symptom scores were associated with higher MetS severity in women but not men (p = 0.005 vs. p = 0.490). There was no difference by depressive symptom score with rate of change in MetS severity over time. Both depressive-symptom score and MetS severity Z-score were associated with lower levels of physical activity and higher levels of C-reactive protein; however, addition of these to the regression model did not attenuate the association between depressive symptoms and MetS severity.
   Conclusion: African American women but not men in the JHS exhibit relationships between baseline depressive symptoms and MetS severity over an 8-year period. These data may have implications for targeting of MetS-associated lifestyle changes among individuals with depressive symptoms. (C) 2016 Published by Elsevier Ltd.
C1 [Gurka, Matthew J.; Vishnu, Abhishek] Univ Florida, Coll Med, Dept Hlth Outcomes & Policy, Gainesville, FL 32608 USA.
   [Okereke, Olivia I.] Brigham & Womens Hosp, Dept Psychiat, Boston, MA 02115 USA.
   [Okereke, Olivia I.] Brigham & Womens Hosp, Dept Med, Channing Div Network Med, Boston, MA 02115 USA.
   [Okereke, Olivia I.] Harvard Univ, Sch Med, TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.
   [Musani, Solomon; Sims, Mario] Univ Mississippi, Med Ctr, Dept Med, Jackson, MS 39213 USA.
   [DeBoer, Mark D.] Univ Virginia, Dept Pediat, Div Pediat Endocrinol, POB 800386, Charlottesville, VA 22908 USA.
C3 State University System of Florida; University of Florida; Harvard
   University; Harvard University Medical Affiliates; Brigham & Women's
   Hospital; Harvard University; Harvard University Medical Affiliates;
   Brigham & Women's Hospital; Harvard University; Harvard T.H. Chan School
   of Public Health; Harvard Medical School; University of Mississippi;
   University of Mississippi Medical Center; University of Virginia
RP DeBoer, MD (corresponding author), Univ Virginia, Dept Pediat, Div Pediat Endocrinol, POB 800386, Charlottesville, VA 22908 USA.
EM deboer@virginia.edu
RI Okereke, Olivia/R-9934-2016
OI Vishnu, Abhishek/0000-0003-3573-4090
FU NIH [1R01HL120960]; National Heart, Lung, and Blood Institute
   [HHSN268201300046C, HHSN268201300047C, HHSN268201300048C,
   HHSN268201300049C, HHSN268201300050C]; National Institute on Minority
   Health and Health Disparities
FX This work was supported by NIH grants 1R01HL120960 (MJG and MDD). The
   Jackson Heart Study is supported by contracts HHSN268201300046C,
   HHSN268201300047C, HHSN268201300048C, HHSN268201300049C,
   HHSN268201300050C from the National Heart, Lung, and Blood Institute and
   the National Institute on Minority Health and Health Disparities.
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NR 48
TC 20
Z9 24
U1 0
U2 15
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD JUN
PY 2016
VL 68
BP 82
EP 90
DI 10.1016/j.psyneuen.2016.02.030
PG 9
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA DM3AF
UT WOS:000376218500011
PM 26963374
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Hatano, T
   Sameshima, Y
   Kawabata, M
   Yamada, S
   Shinozuka, K
   Nakabayashi, T
   Mizuno, H
AF Hatano, Tomoko
   Sameshima, Yuka
   Kawabata, Mami
   Yamada, Shizuo
   Shinozuka, Kazumasa
   Nakabayashi, Toshikatsu
   Mizuno, Hideya
TI St. John's Wort Promotes Adipocyte Differentiation and Modulates NF-κB
   Activation in 3T3-L1 Cells
SO BIOLOGICAL & PHARMACEUTICAL BULLETIN
LA English
DT Article
DE St. John's wort; adipocyte; differentiation; obesity; inflammation
ID NECROSIS-FACTOR-ALPHA; WHITE ADIPOSE-TISSUE; INSULIN-RESISTANCE;
   METABOLIC SYNDROME; RECEPTOR-GAMMA; TRANSCRIPTION FACTOR; ADIPONECTIN;
   PATHWAY; DEPRESSION; PHOSPHORYLATION
AB St. John's wort (SJW), or Hypericum perforatum, is a perennial herb that has been used in the treatment of depression in several countries. Though its therapeutic effect on depression has been extensively studied, its influence on metabolic syndrome is yet to be fully characterized. Therefore, we investigated the effect of SJW extract on adipocyte differentiation and its anti-inflammatory effects by using 3T3-L1 preadipocytes. Oil Red 0 staining indicated that SJW promotes adipocyte differentiation, while immunoblots indicated that SJW increases the expression of peroxisome proliferator activated receptor gamma (PPAR gamma), a nuclear receptor regulating adipocyte differentiation, and adiponectin, an anti-inflammatory adipokine. Furthermore, the anti-inflammatory activity of SJW was demonstrated by its inhibition of the activation of nuclear factor-kappa B (NF-kappa B), an inflammatory transcription factor. Stimulation of mature 3T3-L1 adipocytes by tumor necrosis factor-alpha (TNF-alpha) decreased the expression of the NF-kappa B inhibitor I kappa B alpha, and increased its phosphorylation. Treatment with SJW further decreased the TNF-alpha-induced perturbation in I kappa B alpha expression and phosphorylation, which indicated that SJW mediated the inhibition of NF-kappa B activation. In addition, SJW decreased the TNF-alpha-induced increase in the mRNA levels of pro-inflammatory adipokines, interleukin-6 (IL-6), and monocyte chemoattractant protein-1 (MCP-1). Collectively, our results indicate that SJW treatment could promote adipocyte differentiation probably through its anti-inflammatory activity, which in turn suggests that SJW has the potential to minimize the risk factors of metabolic syndrome.
C1 [Hatano, Tomoko; Sameshima, Yuka; Kawabata, Mami; Shinozuka, Kazumasa; Nakabayashi, Toshikatsu; Mizuno, Hideya] Mukogawa Womens Univ, Sch Pharmaceut Sci, Nishinomiya, Hyogo 6638179, Japan.
   [Yamada, Shizuo] Univ Shizuoka, Dept Pharmacokinet & Pharmacodynam, Sch Pharmaceut Sci, Suruga Ku, Shizuoka 4228526, Japan.
C3 Mukogawa Women's University; University of Shizuoka
RP Mizuno, H (corresponding author), Mukogawa Womens Univ, Sch Pharmaceut Sci, 11-68 Koshien Kyuban Cho, Nishinomiya, Hyogo 6638179, Japan.
EM hmizuno@mukogawa-u.ac.jp
FU Mukogawa Women's University
FX This work was supported by an encouragement grant from Mukogawa Women's
   University. We are grateful to Dr. Naomi Yasui and Dr. Sachiko Inman for
   helpful discussions and technical advice, and to Chieko Yokoyama, Yuka
   Tatara and all of the research students in our laboratory for helping us
   complete the experiments.
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NR 34
TC 17
Z9 18
U1 0
U2 13
PU PHARMACEUTICAL SOC JAPAN
PI TOKYO
PA 2-12-15 SHIBUYA, SHIBUYA-KU, TOKYO, 150-0002, JAPAN
SN 0918-6158
J9 BIOL PHARM BULL
JI Biol. Pharm. Bull.
PD JUL
PY 2014
VL 37
IS 7
BP 1132
EP 1138
DI 10.1248/bpb.b13-00989
PG 7
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA AK2SM
UT WOS:000338269800008
PM 24989005
OA gold
DA 2025-06-11
ER

PT J
AU Conrozier, T
AF Conrozier, Thierry
TI How to Treat Osteoarthritis in Obese Patients?
SO CURRENT RHEUMATOLOGY REVIEWS
LA English
DT Review
DE Obesity; body mass index; osteoarthritis; metabolic syndrome; spa;
   anti-oxidant; SYSADOA; knee; bariatric surgery; weight-loss
ID BODY-MASS INDEX; KNEE OSTEOARTHRITIS; WEIGHT-LOSS; SPA THERAPY; EULAR
   RECOMMENDATIONS; HIP; EFFICACY; VISCOSUPPLEMENTATION; GUIDELINES;
   MANAGEMENT
AB The close association between osteoarthritis (OA) and obesity is well established. Mechanisms linking obesity and OA involve multifactorial phenomena such as systemic factors (i.e. adipokines and pro-inflammatory cytokines), hormonal disturbances (hyperinsulinemia) and muscule changes (i.e. sarcopenia and lower muscular tone). The concomitant increasing prevalence of the two diseases have major health, social and economic consequences. However, to date no specific recommendation for the medical management of obese patients with OA have been published. Current recommendations only specify that obese patients must lose weight and practice regular physical activity in addition to the usual care. Weight loss improves not only OA symptoms but also metabolic abnormalities and cardiovascular risk factors commonly altered in subjects with obesity. OA symptoms' improvement has been shown to become clinically relevant from a weight loss > 5% of the body weight. In case of morbid obesity, bariatric surgery may be the only alternative for pain relief. After bariatric surgery, an appropriate calcium and vitamin D intake is recommended, since it has been shown that bariatric surgery was associated with a reduction in the bone mineral density and increased risk of fractures. An exercise program is essential for preserving healthy muscles during weight loss.
   Non-steroidal anti-inflammatory drugs and corticosteroids must be avoided, especially in obese patients with metabolic syndrome. In such patients symptomatic slow acting drugs for OA (i.e. glucosamine, chondroitin) and some anti-oxidant drugs (i.e. curcumin, ginger extracts, copper) may be helpful thanks to their excellent benefit/risk ratio and their mode of action which may have a positive impact on both OA and obesity-related metabolic disorders. Recent research focuses on the development of molecules aimed for promoting the production of heme oxygenase (HO-1). HO-1 decreases the production of oxygen free radicals and protects tissues from oxidative stress in the insulin resistance syndrome. Intra-articular (IA) injections of hyaluronic acid and corticosteroid have few adverse events. However, physicians must inform patients that IA treatments have a lower success rate in obese patients than in those with normal body mass index. Spa therapy contributes to relief pain, favour weight-loss and reduces metabolic abnormalities with a favourable risk/benefit balance.
C1 [Conrozier, Thierry] Nord Franche Comte Hosp, Dept Rheumatol, Belfort, France.
RP Conrozier, T (corresponding author), Nord Franche Comte Hosp, Dept Rheumatol, Belfort, France.
EM thierry.conrozier@hnfc.fr
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NR 51
TC 13
Z9 14
U1 0
U2 14
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1573-3971
EI 1875-6360
J9 CURR RHEUMATOL REV
JI Curr. Rheumatol. Rev.
PY 2020
VL 16
IS 2
BP 99
EP 104
DI 10.2174/1573397115666190625105759
PG 6
WC Rheumatology
WE Emerging Sources Citation Index (ESCI)
SC Rheumatology
GA LO2ZU
UT WOS:000533499700004
PM 31241017
DA 2025-06-11
ER

PT J
AU Denby, KJ
   Cho, L
   Toljan, K
   Patil, M
   Ferrando, CA
AF Denby, Kara J.
   Cho, Leslie
   Toljan, Karlo
   Patil, Meghana
   Ferrando, Cecile A.
TI Assessment of Cardiovascular Risk in Transaender Patients Presenting for
   Gender-Affirming Care
SO AMERICAN JOURNAL OF MEDICINE
LA English
DT Article
DE Cardiology; Cadiovascular risk; Preventative cadiology; Transgender;
   Transgender health
ID DISEASE; THERAPY; ADULTS; HEALTH
AB BACKGROUND: The transgender population is rapidly growing in the United States and abroad. Transgender men and women are marginalized as a result of their transgender status, with resultant health repercussions. This and other factors such as increased substance use, mental health disorders, violence, and chronic stress may place transgender individuals at higher risk for cardiovascular disease. Additionally, many transgender patients pursue gender-affirming hormone therapy, which has been linked to increased rates of some cardiovascular events such as metabolic syndrome, venous thromboembolism, and stroke. Despite the likelihood of elevated cardiovascular risk in this population, there is a paucity of published data about the cardiovascular risk of this population.
   METHODS: We present baseline cardiovascular data from a transgender population at a large tertiary care center prior to the initiation of hormone therapy.
   RESULTS: The described transgender population had much higher rates of mental health disorders and substance use than the general population. Furthermore, there were high rates of undiagnosed and untreated comorbidities, such as hypertension and dyslipidemia, that increase risk for cardiovascular disease. Baseline risk assessment using the ASCVD (Atherosclerotic Cardiovascular Disease) and QRISK3 calculators showed higher-than-expected cardiovascular risk, particularly given the young age of our patient population.
   CONCLUSIONS: Transgender individuals are at high baseline cardiovascular risk. These data help fill some important knowledge gaps in this patient subgroup, and provide us with much-needed data to help guide our management and counseling of individuals seeking this type of care. (C) 2021 Elsevier Inc. All rights reserved.
C1 [Denby, Kara J.] Cleveland Clin Fdn, Cardiovasc Med Fellowship Program, 9500 Euclid Ave, Cleveland, OH 44195 USA.
   [Cho, Leslie] Cleveland Clin Fdn, Preventat Cardiol & Rehabil, Dept Cardiovasc Med, 9500 Euclid Ave, Cleveland, OH 44195 USA.
   [Toljan, Karlo; Patil, Meghana] Cleveland Clin Fdn, Internal Med Residency Program, 9500 Euclid Ave, Cleveland, OH 44195 USA.
   [Ferrando, Cecile A.] Cleveland Clin Fdn, Cleveland Clin Transgender Surg & Med Program, Obstet & Gynecol, 9500 Euclid Ave, Cleveland, OH 44195 USA.
C3 Cleveland Clinic Foundation; Cleveland Clinic Foundation; Cleveland
   Clinic Foundation; Cleveland Clinic Foundation
RP Denby, KJ (corresponding author), Cleveland Clin Fdn, 9500 Euclid Ave,J3-6, Cleveland, OH 44195 USA.
EM denbyk@ccf.org
RI Toljan, Karlo/AAN-2295-2020
OI Toljan, Karlo/0000-0002-3189-9659
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NR 28
TC 17
Z9 20
U1 0
U2 5
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0002-9343
EI 1555-7162
J9 AM J MED
JI Am. J. Med.
PD AUG
PY 2021
VL 134
IS 8
BP 1002
EP 1008
DI 10.1016/j.amjmed.2021.02.031
EA JUL 2021
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA TX8FY
UT WOS:000683323700017
PM 33895118
DA 2025-06-11
ER

PT J
AU Nakamura, K
   Miyoshi, T
   Yunoki, K
   Ito, H
AF Nakamura, Kazufumi
   Miyoshi, Toru
   Yunoki, Kei
   Ito, Hiroshi
TI Postprandial hyperlipidemia as a potential residual risk factor
SO JOURNAL OF CARDIOLOGY
LA English
DT Review
DE Postprandial hyperlipidemia; Residual risk factor; Triglyceride;
   Coronary heart disease
ID CORONARY-HEART-DISEASE; REMNANT-LIKE PARTICLES; C-REACTIVE PROTEIN;
   ENDOTHELIAL DYSFUNCTION; INSULIN-RESISTANCE; EZETIMIBE; CHOLESTEROL;
   LIPEMIA; WOMEN; HYPERTRIGLYCERIDEMIA
AB Statin therapy targeting reduction of low-density lipoprotein cholesterol (LDL-C) decreases the risk of coronary heart disease (CHD) and all-cause mortality. However, a substantial number of cases of CHD are not prevented and residual risk factors remain unsettled. A high triglyceride (TG) level is considered to be an important and residual risk factor. Postprandial hyperlipidemia is a condition in which TG-rich chylomicron remnants are increased during the postprandial period and hypertriglycedemia is protracted. Postprandial hyperlipidemia evokes atherogenesis during the postprandial period. Several prospective studies have revealed that nonfasting serum TG levels predict the incidence of CHD. Values of TG, remnant lipoprotein cholesterol, and remnant lipoprotein TG after fat loading were significantly higher in diabetes patients with insulin resistance than in diabetes patients without insulin resistance.
   Endothelial dysfunction is an initial process of atherogenesis and it contributes to the pathogenesis of CHD. Postprandial hyperlipidemia (postprandial hypertriglyceridemia) is involved in the production of proinflammatory cytokines, recruitment of neutrophils, and generation of oxidative stress, resulting in endothelial dysfunction in healthy subjects, hypertriglyceridemic patients, or type 2 diabetic patients.
   Effective treatment has not been established till date. Ezetimibe or omega-3 fatty acids significantly decrease postprandial TG elevation and postprandial endothelial dysfunction. Ezetimibe or omega-3 fatty acids added to statin therapy reduce serum TG levels and result in good outcomes in patients with CHD.
   In conclusion, postprandial hyperlipidemia is an important and residual risk factor especially in patients with insulin resistance syndrome (metabolic syndrome) and diabetes mellitus. Further studies are needed to establish effective treatment. (C) 2015 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved.
C1 [Nakamura, Kazufumi; Miyoshi, Toru; Ito, Hiroshi] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Cardiovasc Med, Okayama, Japan.
   [Yunoki, Kei] Okayama Med Ctr, Natl Hosp Org, Div Cardiol, Okayama, Japan.
C3 Okayama University
RP Nakamura, K (corresponding author), 2-5-1 Shikata Cho,Kita Ku, Okayama 7008558, Japan.
EM ichibun@cc.okayama-u.ac.jp
OI Nakamura, Kazufumi/0000-0001-8845-3626
FU MSD; Mochida Pharmaceutical Co., LTD.; Takeda Pharmaceutical Company
   Limited
FX Drs Nakamura, Miyoshi, and Ito have received lecturer fees from MSD. K.
   K, Mochida Pharmaceutical Co., LTD., and Takeda Pharmaceutical Company
   Limited.
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NR 48
TC 91
Z9 98
U1 1
U2 11
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0914-5087
EI 1876-4738
J9 J CARDIOL
JI J. Cardiol.
PD MAR-APR
PY 2016
VL 67
IS 3-4
BP 335
EP 339
DI 10.1016/j.jjcc.2015.12.001
PG 5
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA DK2CR
UT WOS:000374722700022
PM 26744235
OA Bronze
DA 2025-06-11
ER

PT J
AU Chee, KY
   Dain, NAM
   Aziz, SA
   Mokhtar, SSS
   Junus, MM
   Zam, RZ
   Yahya, B
   Cheah, YC
AF Chee, Kok-Yoon
   Dain, Norsiatul Azma Muhammad
   Aziz, Salina Abdul
   Mokhtar, Sharifah Suziah Syed
   Junus, Mazni Mat
   Zam, Ruzanna Zam
   Yahya, Badiah
   Cheah, Yee-Chuan
TI Outcomes of patients with first-episode schizophrenia at one-year
   follow-up: Findings from the National Mental Health Registry in Malaysia
SO ASIA-PACIFIC PSYCHIATRY
LA English
DT Article
DE mental health; outcome; registry; schizophrenia
ID SWITCHING ANTIPSYCHOTICS; PSYCHIATRIC-TREATMENT; METABOLIC SYNDROME; 1ST
   EPISODE; LONG-TERM; DRUG-USE; POLYPHARMACY; PEOPLE; LIFE; OUTPATIENTS
AB Introduction: This first outcome study for people with first-episode schizophrenia (FES) in Malaysia was based on data collected from the National Mental Health Registry (NMHR). The aim of the study was to assess the outcome of patients diagnosed with schizophrenia, one year after contact with mental health services; and to evaluate treatments as well as the utilization of medical and other services in the country. Methods: All patients with FES registered in NMHR between 1 March 2004 and 28 February 2005 were included and 79 centers carried out outcome assessments. Socio-demographic and clinical data were collected and compared with the data in NMHR that was gathered one year ago. Descriptive statistic was used to analyze the data. Results: Of 2604 registered patients with FES, only 37.7% had their outcomes successfully assessed. Among those assessed, 25.5% were lost to follow-up and 45.8% were followed-up in different centers. Only two patients committed suicide. Increases in weight gain and body mass index were major concerns. On a positive note, employability improved. Forty percent of the patients had their antipsychotics changed over the one-year period but about 20% of patients were on polytherapy at baseline and after one year. The use of anticholinergic medication dropped remarkably after the one-year treatment period. Discussion: This study has shown that one of the great barriers in conducting a nationwide outcome assessment of FES patients was the high attrition rate. Nevertheless, these findings provided an important glimpse into the socio-demographic and clinical outcomes of the patients.
C1 [Chee, Kok-Yoon; Aziz, Salina Abdul] Hosp Kuala Lumpur, Dept Psychiat & Mental Hlth, Wilayah Persekutuan, Malaysia.
   [Dain, Norsiatul Azma Muhammad] Mental Hlth Registry Unit, Kuala Lumpur, Wilayah Perseku, Malaysia.
   [Mokhtar, Sharifah Suziah Syed] Hosp Kajang, Dept Psychiat & Mental Hlth, Selangor, Malaysia.
   [Junus, Mazni Mat] Hosp Serdang, Dept Psychiat & Mental Hlth, Selangor, Malaysia.
   [Zam, Ruzanna Zam] Hosp Univ Kebangsaan Malaysia, Dept Psychiat, Kuala Lumpur, Wilayah Perseku, Malaysia.
   [Yahya, Badiah] Hosp Permai, Johor Baharu, Johor, Malaysia.
   [Cheah, Yee-Chuan] Hosp Bahagia, Ipoh, Perak, Malaysia.
C3 Universiti Kebangsaan Malaysia
RP Chee, KY (corresponding author), Kuala Lumpur Hosp, Dept Psychiat & Mental Hlth, Pahang Rd, Kuala Lumpur 50586, Malaysia.
EM cheekokyoon@yahoo.com
FU Ministry of Health; Malaysian Psychiatric Association
FX We wish to thank the Director-General of Health Malaysia for granting
   permission to publish this paper and the Ministry of Health for
   supporting this project financially through the Medical Research Grant.
   We also thank all center site coordinators, medical officers, and
   psychiatrists from the Ministry of Health and university hospitals for
   their commitment, hard work and timely data submission. We are grateful
   to Dato' Dr Aziz Abdullah who served as advisor and the Clinical
   Research Centre, Hospital Kuala Lumpur for technical support and
   guidance. We also extend our appreciation to the Malaysian Psychiatric
   Association and the pharmaceutical industries for their supporting
   grants.
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NR 51
TC 2
Z9 2
U1 0
U2 9
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1758-5864
EI 1758-5872
J9 ASIA-PAC PSYCHIAT
JI Asia-Pac. Psychiatry
PD MAR
PY 2012
VL 4
IS 1
BP 30
EP 39
DI 10.1111/j.1758-5872.2011.00166.x
PG 10
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 899QU
UT WOS:000300832000007
DA 2025-06-11
ER

PT J
AU Gerardo, H
   Oliveira, PJ
   Cavadas, C
   Graos, M
   Teixeira, J
AF Gerardo, Heloisa
   Oliveira, Paulo J.
   Cavadas, Claudia
   Graos, Mario
   Teixeira, Jose
TI The (un)known crosstalk between metabolism and mechanotransduction:
   Implications for metabolic syndrome (MetS)-associated neurological
   complications
SO BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
LA English
DT Review
DE Keywords; Metabolic syndrome; Cellular metabolism; Metabolic rewiring;
   Mechanotransduction; Tissue stiffness
ID OXIDATIVE STRESS; ALZHEIMERS-DISEASE; REDOX HOMEOSTASIS; F-ACTIN;
   AUTOPHAGY; ENERGY; YAP/TAZ; HIPPOCAMPUS; MODULATION; INDUCTION
AB Metabolic syndrome (MetS) has been associated with disruptions in tissue mechanical homeostasis and inflammatory and metabolic derangements. However, the direct correlation between metabolic alterations and changes in tissue stiffness, and whether they could play a role as upstream initiators of disease pathology remains to be investigated. This emerging concept has yet to be put into clinical practice as many questions concerning the interplay between extracellular matrix mechanical properties and regulation of metabolic pathways remain unsolved. This review will highlight key foundational studies examining mutual regulation of cell metabolism and mechanotransduction, and opening questions lying ahead for better understanding MetS pathophysiology.
C1 [Gerardo, Heloisa; Oliveira, Paulo J.; Cavadas, Claudia; Teixeira, Jose] Univ Coimbra, Ctr Neurosci & Cell Biol, CNC UC, Coimbra, Portugal.
   [Gerardo, Heloisa; Oliveira, Paulo J.; Cavadas, Claudia; Graos, Mario; Teixeira, Jose] Univ Coimbra, Ctr Innovat Biomed & Biotechnol, CIBB, Coimbra, Portugal.
   [Gerardo, Heloisa; Cavadas, Claudia] Univ Coimbra, Fac Pharm, Coimbra, Portugal.
C3 Universidade de Coimbra; Universidade de Coimbra; Universidade de
   Coimbra
RP Teixeira, J (corresponding author), Univ Coimbra, CNC Ctr Neurosci & Cell Biol, CIBB Ctr Innovat Biomed & Biotechnol, P-3060197 Coimbra, Portugal.
EM hgerardo@cnc.uc.pt; pauloliv@ci.uc.pt; ccavadas@ci.uc.pt;
   jteixeira@cnc.uc.pt
RI Oliveira, Paulo/AAQ-8943-2020; Cavadas, Claudia/A-8722-2019; Graos,
   Mario/O-7273-2017; Santos Teixeira, Jose Carlos/N-9862-2014; Oliveira,
   Paulo/H-1980-2011
OI Cavadas, Claudia/0000-0001-8020-9266; Graos, Mario/0000-0002-2707-1488;
   Santos Teixeira, Jose Carlos/0000-0003-0834-5698; Oliveira,
   Paulo/0000-0002-5201-9948; Gerardo, Heloisa/0000-0003-1492-1882
FU European Regional Development Fund (ERDF); COMPETE 2020-Operational
   Programme for Competitiveness and Internationalisation and Portuguese
   national funds via FCT [EXPL/BIA-BQM/1361/2021]; European Union
   [101080329]; FCT, I.P. [2020.01560.CEECIND];  [UIDP/04539/2020]; 
   [LA/P/0058/2020];  [SFRH/BD/147316/2019];  [COVID/BD/153559/2024]
FX This work was financed by the European Regional Development Fund (ERDF)
   , through the Centro 2020 Regional Operational Programme and through the
   COMPETE 2020-Operational Programme for Competitiveness and
   Internationalisation and Portuguese national funds via FCT, under
   project[s] : EXPL/BIA-BQM/1361/2021, UIDP/04539/2020 and LA/P/0058/2020.
   PAS GRAS project has received funding from the European Union's Horizon
   Europe under grant agreement No 101080329. H. Gerardo
   (SFRH/BD/147316/2019 and COVID/BD/153559/2024) and J. Teixeira
   (2020.01560.CEECIND) acknowledges FCT, I.P. for the research contract.
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NR 84
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0925-4439
EI 1879-260X
J9 BBA-MOL BASIS DIS
JI Biochim. Biophys. Acta-Mol. Basis Dis.
PD MAR
PY 2025
VL 1871
IS 3
AR 167678
DI 10.1016/j.bbadis.2025.167678
EA JAN 2025
PG 9
WC Biochemistry & Molecular Biology; Biophysics; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Cell Biology
GA U0C4O
UT WOS:001408577100001
PM 39832691
OA hybrid
DA 2025-06-11
ER

PT J
AU Gil-Cardoso, K
   Del Bas, JM
   Caimari, A
   Lama, C
   Torres, S
   Mantecón, L
   Infante, C
AF Gil-Cardoso, Katherine
   Del Bas, Josep M.
   Caimari, Antoni
   Lama, Carmen
   Torres, Sonia
   Mantecon, Lalia
   Infante, Carlos
TI TetraSOD®, a Unique Marine Microalgae Ingredient, Promotes an
   Antioxidant and Anti-Inflammatory Status in a Metabolic Syndrome-Induced
   Model in Rats
SO NUTRIENTS
LA English
DT Article
DE TetraSOD (R); Tetraselmis chuii; microalgae; metabolic syndrome;
   oxidative stress; inflammation
ID HIGH-FAT DIET; LOW-DENSITY-LIPOPROTEIN; OXIDATIVE STRESS; CAFETERIA
   DIET; NITRIC-OXIDE; GLUTATHIONE METABOLISM; ADIPOKINE IMBALANCE;
   INFLAMMATORY STATUS; INSULIN-RESISTANCE; CYTOKINE SYNTHESIS
AB Increased oxidative stress has been linked to the pathogenic process of obesity and can trigger inflammation, which is often linked with the risk factors that make up metabolic syndrome (MetS), including obesity, insulin resistance, dyslipidaemia and hypertension. TetraSOD (R), a natural marine vegan ingredient derived from the microalgae Tetraselmis chuii that is high in the antioxidant enzymes superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) has recently demonstrated in vitro increased activity of these key antioxidant enzymes. In the present study, the potential bioactive effects of three dietary dosages of TetraSOD (R) in enhancing antioxidant and anti-inflammatory mechanisms to combat the metabolic disturbances that compose MetS were assessed in rats given a cafeteria (CAF) diet. Chronic supplementation with 0.17, 1.7, and 17 mg kg(-1) day(-1) of TetraSOD (R) for 8 weeks ameliorated the abnormalities associated with MetS, including oxidative stress and inflammation, promoting endogenous antioxidant defence mechanisms in the liver (GPx and GSH), modulating oxidative stress and inflammatory markers in plasma (NOx, oxLDL and IL-10), and regulating genes involved in antioxidant, anti-inflammatory and immunomodulatory pathways in the liver, mesenteric white adipose tissue (MWAT), thymus, and spleen. Overall, TetraSOD (R) appears to be a potential therapeutic option for the management of MetS.
C1 [Gil-Cardoso, Katherine; Del Bas, Josep M.] Eurecat, Technol Unit Nutr & Hlth, Ctr Tecnol Catalunya, Reus 43204, Spain.
   [Caimari, Antoni] Eurecat, Biotechnol Area, Ctr Tecnol Catalunya, Reus 43204, Spain.
   [Lama, Carmen; Torres, Sonia; Mantecon, Lalia; Infante, Carlos] Fitoplancton Marino SL, Darsena Comercial S-N, Cadiz 11500, Spain.
RP Infante, C (corresponding author), Fitoplancton Marino SL, Darsena Comercial S-N, Cadiz 11500, Spain.
EM carlos.infante@easyalgae.com
RI del Bas, Josep/K-9310-2019
OI del Bas, Josep Maria/0000-0002-0700-2004; Infante,
   Carlos/0000-0002-6158-9344
FU Fitoplancton Marino, S.L.
FX Present study was sponsored by Fitoplancton Marino, S.L., the
   manufacturer of TetraSOD (R). This research received no external
   funding.
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PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD OCT
PY 2022
VL 14
IS 19
AR 4028
DI 10.3390/nu14194028
PG 24
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 5H8UE
UT WOS:000867947100001
PM 36235679
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Thethi, TK
   Parsha, K
   Rajapurkar, M
   Mukhopadhyay, B
   Shah, S
   Yau, CL
   Japa, S
   Fonseca, V
AF Thethi, Tina K.
   Parsha, Kaushik
   Rajapurkar, Mohan
   Mukhopadhyay, Banibrata
   Shah, Sudhir
   Yau, C. Lillian
   Japa, Shanker
   Fonseca, Vivian
TI Urinary Catalytic Iron in Obesity
SO CLINICAL CHEMISTRY
LA English
DT Article
ID CHRONIC KIDNEY-DISEASE; INSULIN-RESISTANCE SYNDROME; METABOLIC SYNDROME;
   NEPHROTIC SYNDROME; SERUM FERRITIN; MYOCARDIAL-INFARCTION;
   HEART-DISEASE; RISK; ATHEROSCLEROSIS; STORES
AB INTRODUCTION: Obesity precedes the development of many cardiovascular disease risk factors, including type 2 diabetes mellitus (DM), hypertension, and chronic kidney disease. Catalytic iron, which has been associated with these chronic diseases, may be one of the links between obesity and these multifactorial diverse disorders.
   OBJECTIVE: We investigated whether urinary catalytic iron is increased in obese individuals without DM and overt kidney disease.
   STUDY DESIGN: We measured urinary catalytic iron using established methods in 200 randomly selected individuals without DM [100 who were obese (body mass index >= 30 kg/m(2)) and 100 who were nonobese (body mass index <= 27)]. Participants were selected from an outpatient clinic and community setting and were part of an ongoing cross-sectional study of obesity in individuals between the ages of 18 and 70 years.
   RESULTS: There was a significant difference in mean (95% CI) urinary catalytic iron excretion between the obese participants and the nonobese participants, 463 (343-582) nmol/mg [52.3 (38.8-65.8) nmol/mu mol] vs 197 (141-253) nmol/mg [22.3 (15.9-28.6) nmol/mu mol]; P < 0.001. The significant predictors of increased urinary catalytic iron were obesity (P = 0.001) and waist-to-hip ratio (P = 0.03).
   CONCLUSIONS: Our study results demonstrate that obesity and waist-to-hip ratio are associated with increased urinary catalytic iron, which may be a useful marker of oxidative stress. Additional studies are needed to determine the role of catalytic iron in increased cardiovascular disease and chronic kidney disease associated with obesity. (C) 2010 American Association for Clinical Chemistry
C1 [Thethi, Tina K.; Parsha, Kaushik; Japa, Shanker; Fonseca, Vivian] Tulane Univ, Hlth Sci Ctr, New Orleans, LA 70118 USA.
   [Rajapurkar, Mohan; Mukhopadhyay, Banibrata] Muljibhai Patel Soc Res Nephrourol, Nadiad, Gujarat, India.
   [Shah, Sudhir] Univ Arkansas Med Sci, Coll Med, Little Rock, AR 72205 USA.
   [Yau, C. Lillian] Tulane Univ, Sch Publ Hlth & Trop Med, New Orleans, LA USA.
C3 Tulane University; University of Arkansas System; University of Arkansas
   Medical Sciences; Tulane University
RP Thethi, TK (corresponding author), 1430 Tulane Ave,SL-53, New Orleans, LA 70112 USA.
EM tthethi@tulane.edu
RI Parsha, Kaushik/AAY-8159-2020
OI Mukhopadhyay, Banibrata/0000-0002-2226-5857; Parsha,
   Kaushik/0000-0001-5230-3095
FU Eunice Kennedy Shriver National Institute of Child Health and Human
   Development [K12HD043451]; National Institutes of Health [TINSAL-2D];
   American Diabetes Association; Tullis-Tulane Chair of Diabetes; Tulane
   University; Clinical and Translational Research Center; Susan Harling
   Robinson Fellowship; Tullis-Tulane Alumni Chair in Diabetes
FX T.K. Thethi, from the Eunice Kennedy Shriver National Institute of Child
   Health and Human Development, award number K12HD043451; V. Fonseca,
   National Institutes of Health (ACCORD, TINSAL-2D), the American Diabetes
   Association, and the Tullis-Tulane Chair of Diabetes. Funding for this
   study is provided by the Tulane University Phase II Research Enhancement
   Fund and is supported by the Clinical and Translational Research Center.
   Diabetes research at Tulane University Health Sciences Center is
   supported in part by the Susan Harling Robinson Fellowship in Diabetes
   Research and the Tullis-Tulane Alumni Chair in Diabetes.
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NR 43
TC 5
Z9 6
U1 0
U2 6
PU AMER ASSOC CLINICAL CHEMISTRY
PI WASHINGTON
PA 2101 L STREET NW, SUITE 202, WASHINGTON, DC 20037-1526 USA
SN 0009-9147
EI 1530-8561
J9 CLIN CHEM
JI Clin. Chem.
PD FEB
PY 2011
VL 57
IS 2
BP 272
EP 278
DI 10.1373/clinchem.2010.154757
PG 7
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA 712GD
UT WOS:000286653000021
PM 21189275
DA 2025-06-11
ER

PT J
AU González-Muniesa, P
   Marrades, MP
   Martínez, JA
   Moreno-Aliaga, MJ
AF Gonzalez-Muniesa, Pedro
   Pilar Marrades, Maria
   Alfredo Martinez, Jose
   Jesus Moreno-Aliaga, Maria
TI Differential Proinflammatory and Oxidative Stress Response and
   Vulnerability to Metabolic Syndrome in Habitual High-Fat Young Male
   Consumers Putatively Predisposed by Their Genetic Background
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE metabolic syndrome; microarray; inflammation; oxidative stress;
   subcutaneous adipose tissue
ID POLYCYSTIC-OVARY-SYNDROME; ENDOPLASMIC-RETICULUM STRESS;
   INFLAMMATION-RELATED GENES; WHITE ADIPOSE-TISSUE; FINNISH DIABETES
   PREVENTION; ELEVATED CIRCULATING LEVELS; NONOBESE PIMA-INDIANS;
   INSULIN-RESISTANCE; HUMAN OBESITY; WEIGHT-LOSS
AB The current nutritional habits and lifestyles of modern societies favor energy overloads and a diminished physical activity, which may produce serious clinical disturbances and excessive weight gain. In order to investigate the mechanisms by which the environmental factors interact with molecular mechanisms in obesity, a pathway analysis was performed to identify genes differentially expressed in subcutaneous abdominal adipose tissue (SCAAT) from obese compared to lean male (21-35 year-old) subjects living in similar obesogenic conditions: habitual high fat dietary intake and moderate physical activity. Genes involved in inflammation (ALCAM, CTSB, C1S, YKL-40, MIF, SAA2), extracellular matrix remodeling (MMP9, PALLD), angiogenesis (EGFL6, leptin) and oxidative stress (AKR1C3, UCHL1, HSPB7 and NQO1) were upregulated; whereas apoptosis, signal transcription (CITED 2 and NR3C1), cell control and cell cycle-related genes were downregulated. Interestingly, the expression of some of these genes (C1S, SAA2, ALCAM, CTSB, YKL-40 and tenomodulin) was found to be associated with some relevant metabolic syndrome features. The obese group showed a general upregulation in the expression of inflammatory, oxidative stress, extracellular remodeling and angiogenic genes compared to lean subjects, suggesting that a given genetic background in an obesogenic environment could underlie the resistance to gaining weight and obesity-associated manifestations.
C1 [Gonzalez-Muniesa, Pedro; Pilar Marrades, Maria; Alfredo Martinez, Jose; Jesus Moreno-Aliaga, Maria] Univ Navarra, Dept Nutr Food Sci & Physiol, Pamplona 31008, Spain.
   [Gonzalez-Muniesa, Pedro; Alfredo Martinez, Jose; Jesus Moreno-Aliaga, Maria] Ctr Biomed Res Network, CIBERobn Physiopathol Obes & Nutr, Madrid 29029, Spain.
C3 University of Navarra; CIBER - Centro de Investigacion Biomedica en Red;
   CIBEROBN
RP Moreno-Aliaga, MJ (corresponding author), Univ Navarra, Dept Nutr Food Sci & Physiol, Pamplona 31008, Spain.
EM pgonmun@unav.es; pmarrades@unav.es; jalfmtz@unav.es; mjmoreno@unav.es
RI Martinez Hernandez, J Alfredo/K-8709-2014; Gonzalez-Muniesa,
   Pedro/H-2158-2015; Moreno-Aliaga, Maria J./M-7015-2018
OI Martinez Hernandez, J Alfredo/0000-0001-5218-6941; Gonzalez-Muniesa,
   Pedro/0000-0002-3130-2496; Moreno-Aliaga, Maria J./0000-0002-2018-6434
FU Government of Navarra (Health Department); Linea Especial of the
   University of Navarra [LE/97]; CIBERobn scheme
FX We would like to thank Veronica Ciaurriz and Ana Lorente for their help;
   we also acknowledge the receipt of funding from the Government of
   Navarra (Health Department) and the Linea Especial of the University of
   Navarra (LE/97). The support from CIBERobn scheme is gratefully
   accredited.
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NR 95
TC 27
Z9 31
U1 1
U2 21
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD SEP
PY 2013
VL 14
IS 9
BP 17238
EP 17255
DI 10.3390/ijms140917238
PG 18
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 274RN
UT WOS:000328623900001
PM 23975165
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Melcescu, E
   Griswold, M
   Xiang, LB
   Belk, S
   Montgomery, D
   Bray, M
   Del Ben, KS
   Uwaifo, GI
   Marshall, GD
   Koch, CA
AF Melcescu, Eugen
   Griswold, Michael
   Xiang, Lianbin
   Belk, Sheila
   Montgomery, Denise
   Bray, Marilyn
   Del Ben, Kevin S.
   Uwaifo, Gabriel I.
   Marshall, Gailen D.
   Koch, Christian A.
TI Prevalence and cardiometabolic associations of the glucocorticoid
   receptor gene polymorphisms N363S and BclI in obese and non-obese
   black and white Mississippians
SO HORMONES-INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM
LA English
DT Article
DE Glucocorticoid receptor; Polymorphism; BclI; Diabetes; Stress; Body mass
   index; Waist circumference; Obesity
ID BODY-MASS INDEX; WAIST CIRCUMFERENCE; STRESS; RISK; DISEASE; GREECE;
   HYPERTENSION; HEMOGLOBIN; DEPRESSION; PREDICTION
AB OBJECTIVE: Polymorphisms (SNP) in the glucocorticoid receptor (GR) gene can alter sensitivity to glucocorticoids. Previous studies of the N363S and Bail SNP in the GR gene have shown a metabolic syndrome phenotype in mostly non-African populations. The obesity phenotype of African Americans (AA) seems to be more severe than that of Caucasians. DESIGN: We aimed to assess the prevalence of N363S and Bali in obese and non-obese Caucasian (n=26) and African (n=23) Mississippians (age: 23-63 years) to investigate associations with body composition (body mass index/BMI, waist-to-hip ratio), metabolic parameters (salivary cortisol, fasting glucose and insulin, hemoglobin A1C, fructosamine, HOMA-IR index), and psychological stress perception (blood pressure/BP, perceived stress scale/PSS). RESULTS: All subjects were homozygous for wildtype N363N. BclI polymorphism genotype frequencies among the 23 AA were: homozygous CC (57%), GG (4%), and heterozygous CG (39%), and among the 26 white women: homozygous CC (35%), GG (19%), and heterozygous CG (46%). Linear and logistic regression analyses including a parsimonious model identified BMI as a statistically significant parameter between the two ethnic groups (BMI was 3.13 kg/m(2) higher in AA). Within the AA group, BMI, waist-to-hip ratio, log (HIOMA-IR), PSS scores, P, and hyperlipidemia showed no statistically significant relationships for the BclI polymorphism. PSS scores were 15.2 for AA vs. 14.7 for white women (normal mean: 14.7 vs. 12.8). CONCLUSION: lack Mississippians have a higher BMI than whites, which may be related to the presence of the BclI polymorphism and increased glucocorticoid sensitivity. Although more blacks (52%) than whites (38%) had elevated BP, PSS scores in both groups suggest that a high BMI is not regarded as abnormal or stressful. This might negatively impact behavior change regarding lifestyle modifications with increased physical activity and healthier food choices. Larger studies, particularly in African populations, are needed to better define metabolic and psychological characteristics in relation to the N363S and BclI GR gene polymorphisms.
C1 [Melcescu, Eugen; Uwaifo, Gabriel I.; Koch, Christian A.] Univ Mississippi, Sch Med, Div Endocrinol, Jackson, MS 39216 USA.
   [Griswold, Michael] Univ Mississippi, Sch Med, Ctr Biostat & Bioinformat, Jackson, MS 39216 USA.
   [Xiang, Lianbin; Belk, Sheila; Montgomery, Denise; Del Ben, Kevin S.; Marshall, Gailen D.] Univ Mississippi, Sch Med, Div Allergy & Clin Immunol, Jackson, MS 39216 USA.
   [Uwaifo, Gabriel I.] Univ Mississippi, Sch Med, Dept Pathol, Jackson, MS 39216 USA.
   [Uwaifo, Gabriel I.] Louisiana State Univ, Hlth Sci Ctr, Div Endocrinol, New Orleans, LA 70112 USA.
   [Koch, Christian A.] GV Sonny Montgomery VA Med Ctr, Med Serv, Jackson, MS USA.
C3 University of Mississippi; University of Mississippi Medical Center;
   University of Mississippi; University of Mississippi Medical Center;
   University of Mississippi; University of Mississippi Medical Center;
   University of Mississippi Medical Center; University of Mississippi;
   Louisiana State University System; Louisiana State University Health
   Sciences Center New Orleans
RP Koch, CA (corresponding author), Univ Mississippi, Med Ctr, Endocrine Tumor Programme, Div Endocrinol, 2500 N State Str, Jackson, MS 39216 USA.
EM ckoch@umc.edu
RI Koch, Christian/A-4699-2008; Marshall, Gailen/R-7459-2019; Uwaifo,
   Gabriel/M-2361-2016
OI Uwaifo, Gabriel/0000-0002-6962-9304; Koch, Christian/0000-0003-0678-1242
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NR 54
TC 14
Z9 15
U1 1
U2 5
PU SPRINGER INTERNATIONAL PUBLISHING AG
PI CHAM
PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND
SN 1109-3099
EI 2520-8721
J9 HORM-INT J ENDOCRINO
JI Horm.-Int. J. Endocrinol. Metab.
PD APR-JUN
PY 2012
VL 11
IS 2
BP 166
EP 177
DI 10.14310/horm.2002.1344
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 970UT
UT WOS:000306158500006
PM 22801563
OA Bronze
DA 2025-06-11
ER

PT J
AU Grünblatt, E
   Bartl, J
   Riederer, P
AF Gruenblatt, Edna
   Bartl, Jasmin
   Riederer, Peter
TI The link between iron, metabolic syndrome, and Alzheimer's disease
SO JOURNAL OF NEURAL TRANSMISSION
LA English
DT Review
DE Alzheimer's disease; beta-Amyloid; Diabetes; Heme oxygenase-1; Insulin
   resistance; Iron; Metabolic syndrome; Metallothionein; Mitochondria;
   Oxidative stress; Reactive oxygen species (ROS)
ID TYPE-2 DIABETES-MELLITUS; CEREBRAL ENERGY-METABOLISM; NEURONAL
   INSULIN-RECEPTOR; AMYLOID-BETA-PEPTIDES; RESISTANT BRAIN STATE;
   OXIDATIVE STRESS; SERUM FERRITIN; TRANSFERRIN RECEPTORS; COGNITIVE
   IMPAIRMENT; PANCREATIC-ISLETS
AB Both Alzheimer's disease (AD), the most common form of dementia, and type-2 diabetes mellitus (T2DM), a disease associated with metabolic syndrome (MetS), affect a great number of the world population and both have increased prevalence with age. Recently, many studies demonstrated that pre-diabetes, MetS, and T2DM are risk factors in the development of AD and have many common mechanisms. The main focus of studies is the insulin resistance outcome found both in MetS as well as in brains of AD subjects. However, oxidative stress (OS)-related mechanisms, which are well known to be involved in AD, including mitochondrial dysfunction, elevated iron concentration, reactive oxygen species (ROS), and stress-related enzyme or proteins (e.g. heme oxygenase-1, transferrin, etc.), have not been elucidated in MetS or T2DM brains although OS and iron are involved in the degeneration of the pancreatic islet beta cells. Therefore, this review sets to cover the current literature regarding OS and iron in MetS and T2DM and the similarities to mechanisms in AD both in human subjects as well as in animal models.
C1 [Gruenblatt, Edna] Univ Zurich, Dept Child & Adolescent Psychiat, CH-8032 Zurich, Switzerland.
   [Gruenblatt, Edna; Bartl, Jasmin; Riederer, Peter] Univ Wurzburg, Natl Parkinson Fdn Ctr Excellence Labs, Neurochem Lab, Clin & Policlin Psychiat Psychosomat & Psychother, D-97080 Wurzburg, Germany.
C3 University of Zurich; University of Wurzburg
RP Grünblatt, E (corresponding author), Univ Zurich, Dept Child & Adolescent Psychiat, Neumuensterallee 9, CH-8032 Zurich, Switzerland.
EM Gruenblatt_E@klinik.uni-wuerzburg.de
RI Bartl, Jasmin/F-2315-2014; Grunblatt, Edna/A-6762-2016
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NR 146
TC 49
Z9 53
U1 0
U2 21
PU SPRINGER WIEN
PI Vienna
PA Prinz-Eugen-Strasse 8-10, A-1040 Vienna, AUSTRIA
SN 0300-9564
EI 1435-1463
J9 J NEURAL TRANSM
JI J. Neural Transm.
PD MAR
PY 2011
VL 118
IS 3
BP 371
EP 379
DI 10.1007/s00702-010-0426-3
PG 9
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 737HB
UT WOS:000288558600008
PM 20556444
OA Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Hadi, S
   Daryabeygi-Khotbehsara, R
   Mirmiran, P
   McVicar, J
   Hadi, V
   Soleimani, D
   Askari, G
AF Hadi, Saeid
   Daryabeygi-Khotbehsara, Reza
   Mirmiran, Parvin
   McVicar, Jenna
   Hadi, Vahid
   Soleimani, Davood
   Askari, Gholamreza
TI Effect of Nigella sativa oil extract on cardiometabolic risk
   factors in type 2 diabetes: A randomized, double-blind,
   placebo-controlled clinical trial
SO PHYTOTHERAPY RESEARCH
LA English
DT Article
DE blood pressure; glycemic control; Nigella sativa; serum lipids; type 2
   diabetes; weight
ID INFLAMMATORY CYTOKINE RESPONSE; PANCREATIC BETA-CELLS; OXIDATIVE STRESS;
   ANTIDIABETIC ACTIVITY; RHEUMATOID-ARTHRITIS; INSULIN-RELEASE;
   SKELETAL-MUSCLE; SEED EXTRACT; GLUCOSE; THYMOQUINONE
AB The objective of this study was to determine the effects of Nigella sativa oil extract on cardiometabolic risk factors in people with type 2 diabetes (T2D). A randomized, controlled, clinical trial was conducted on 43 patients with T2D (23 women and 20 men; aged 53.5 +/- 7.4 years). The intervention group (N = 23) received two 500-mg per day soft gel capsules containing Nigella sativa oil extract and the control group (N = 20) received two identical placebo soft gel capsules containing sunflower oil per day for the same period, 8 weeks. Pre- and post-intervention cardiometabolic risk factors were measured. Compared with the placebo, the N. sativa oil significantly decreased FBS (p = .03(, HbA1c (p = .001), total cholesterol (p = .04), TG (p = .003), LDL-c (p = .001), BMI (p < .001), waist circumference (p < .001), SBP (p = .001), and DBP (p = .002). HOMA-IR (p = .51) and HDL-c (p = .91) did not change significantly following Nigella sativa supplementation. Nigella sativa oil exerted beneficial effects on glycemic control, serum lipid profile, blood pressure, and body weight among people with T2D. Further long-term trials in the future may help confirm the current therapeutic benefits of Nigella sativa in T2D.
C1 [Hadi, Saeid; Askari, Gholamreza] Isfahan Univ Med Sci, Sch Nutr & Food Sci, Dept Community Nutr, POB 00983117922110, Esfahan, Iran.
   [Daryabeygi-Khotbehsara, Reza; McVicar, Jenna] Deakin Univ, Inst Phys Act & Nutr IPAN, Melbourne, Vic, Australia.
   [Mirmiran, Parvin] Shahid Beheshti Univ Med Sci, Dept Nutr, Tehran, Iran.
   [Hadi, Vahid] AJA Univ Med Sci, Dept Hlth, Sci & Res Branch, Tehran, Iran.
   [Soleimani, Davood] Kermanshah Univ Med Sci, Sch Nutr Sci & Food Technol, Nutr Sci Dept, Kermanshah, Iran.
   [Askari, Gholamreza] Isfahan Univ Med Sci, Food Secur Res Ctr, Esfahan, Iran.
C3 Isfahan University of Medical Sciences; Deakin University; Shahid
   Beheshti University Medical Sciences; Kermanshah University of Medical
   Sciences; Isfahan University of Medical Sciences
RP Askari, G (corresponding author), Isfahan Univ Med Sci, Sch Nutr & Food Sci, Dept Community Nutr, POB 00983117922110, Esfahan, Iran.
EM askari@mui.ac.ir
RI askari, gholamreza/M-9362-2016; Mirmiran, Parvin/V-1433-2019;
   Daryabeygi-Khotbehsara, Reza/AAK-1110-2021; Daryabeygi, Reza/H-6122-2013
OI Daryabeygi, Reza/0000-0003-4064-978X; McVicar,
   Jenna/0000-0001-5007-7223; SOLEIMANI, DAVOOD/0000-0002-9017-3743;
   Rahimlou, Mehran/0000-0002-7861-8287
FU Shahid Beheshti University of Medical Sciences [4960/]
FX Shahid Beheshti University of Medical Sciences, Grant/Award Number:
   4960/./92
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NR 48
TC 29
Z9 29
U1 2
U2 11
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0951-418X
EI 1099-1573
J9 PHYTOTHER RES
JI Phytother. Res.
PD JUL
PY 2021
VL 35
IS 7
BP 3747
EP 3755
DI 10.1002/ptr.6990
EA JUN 2021
PG 9
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA TS8TH
UT WOS:000662724800001
PM 34142392
DA 2025-06-11
ER

PT J
AU Rademacher, ER
   Jacobs, DR
   Moran, A
   Steinberger, J
   Prineas, RJ
   Sinaiko, A
AF Rademacher, Erin R.
   Jacobs, David R., Jr.
   Moran, Antoinette
   Steinberger, Julia
   Prineas, Ronald J.
   Sinaiko, Alan
TI Relation of blood pressure and body mass index during childhood to
   cardiovascular risk factor levels in young adults
SO JOURNAL OF HYPERTENSION
LA English
DT Article
DE adolescents; blood pressure; body mass index; risk factors; young adults
ID INSULIN-RESISTANCE SYNDROME; METABOLIC SYNDROME; OXIDATIVE STRESS;
   FASTING INSULIN; ADIPOSE-TISSUE; FOLLOW-UP; OBESITY; HYPERTENSION;
   OVERWEIGHT; CHILDREN
AB Introduction Adult obesity and hypertension are leading causes of cardiovascular morbidity/mortality. Although childhood BMI and blood pressure (BP) track into adulthood, how they influence adult cardiovascular risk independent of each other is not well defined.
   Methods Participants were from two longitudinal studies with a baseline evaluation at mean age of 13 years and a follow-up at mean age of 24 years. Regression models using childhood BP and BMI to predict young adult cardiovascular risk factors were performed.
   Results In univariate analysis, childhood BMI predicted young adult BP, lipids, glucose, insulin and insulin resistance, whereas childhood BP predicted young adult BP, lipids and glucose. In a multivariable regression model (adjusted for age, sex and race), which included change in BMI and BP from age 13 to 24 years, BMI predicted all young adult risk factors except BP and glucose. Baseline SBP predicted young adult BP, cholesterol, triglycerides and glucose whereas baseline DBP predicted young adult BP, BMI and glucose.
   Conclusion The results from this study show that BP and BMI act independently in children to influence future cardiovascular risk factors and the combination of high BP and BMI in childhood has an additive effect in predicting the highest levels of young adult cardiovascular risk. Thus, there should be a focus on treating hypertension in overweight and obese children, in addition to attempting to reduce weight. J Hypertens 27:1766-1774 (C) 2009 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
C1 [Rademacher, Erin R.] Univ Rochester, Dept Pediat, Rochester, NY 14642 USA.
   [Jacobs, David R., Jr.; Sinaiko, Alan] Univ Minnesota, Sch Publ Hlth, Div Epidemiol, Minneapolis, MN 55455 USA.
   [Jacobs, David R., Jr.] Univ Oslo, Dept Nutr, Oslo, Norway.
   [Moran, Antoinette; Steinberger, Julia; Sinaiko, Alan] Univ Minnesota, Dept Pediat, Minneapolis, MN 55455 USA.
   [Prineas, Ronald J.] Wake Forest Univ, Dept Epidemiol & Prevent, Div Publ Hlth Sci, Winston Salem, NC 27109 USA.
C3 University of Rochester; University of Minnesota System; University of
   Minnesota Twin Cities; University of Oslo; University of Minnesota
   System; University of Minnesota Twin Cities; Wake Forest University
RP Rademacher, ER (corresponding author), Univ Rochester, Dept Pediat, 601 Elmwood Ave,Box 777, Rochester, NY 14642 USA.
EM erin_rademacher@urmc.rochester.edu
RI Jacobs, David/G-5405-2011; Stefanadis, Christodoulos/ABH-2232-2020
OI Jacobs, David/0000-0002-7232-0543; Stefanadis,
   Christodoulos/0000-0001-5974-6454; Steinberger,
   Julia/0000-0002-2892-8594
FU National Institute of Health [HL 34659, HL 52851, M01RR00400]
FX This study was supported by grants HL 34659, HL 52851 and M01RR00400
   from the National Institute of Health.This work was presented in part at
   the ASPN/PAS 2008 annual meeting.
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NR 53
TC 77
Z9 83
U1 0
U2 20
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0263-6352
EI 1473-5598
J9 J HYPERTENS
JI J. Hypertens.
PD SEP
PY 2009
VL 27
IS 9
BP 1766
EP 1774
DI 10.1097/HJH.0b013e32832e8cfa
PG 9
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 491AP
UT WOS:000269549500008
PM 19633567
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Dorranipour, D
   Pourjafari, F
   Malekpour-Afshar, R
   Basiri, M
   Hosseini, M
AF Dorranipour, Davood
   Pourjafari, Fahimeh
   Malekpour-Afshar, Reza
   Basiri, Mohsen
   Hosseini, Mehran
TI RETRACTED: Astrocyte response to melatonin treatment in rats under
   high-carbohydrate high-fat diet
SO JOURNAL OF CHEMICAL NEUROANATOMY
LA English
DT Article; Retracted Publication
DE Melatonin; Astrogliosis; Neuroinflammation; Oxidative stress; Metabolic
   Syndrome
ID EXPERIMENTAL-MODELS; METABOLIC SYNDROME; LIVER-DISEASE; IMPAIRMENT;
   MEMORY; SUPEROXIDE
AB The involvement of consumption of high-carbohydrate high-fat (HCHF) diet in cognitive impairment is attributed, at least in part, to the activation of astrocytes, which contributes to the development of neuroinflammation, oxidative stress, and subsequent cognitive deficits. This study aimed to assess the influence of melatonin on cognitive impairment and astrogliosis induced by the HCHF diet in rats. Male Wistar rats were fed an HCHF diet for eight weeks to induce obesity and metabolic syndrome. Subsequently, they received oral melatonin treatment for four weeks at doses of 5 mg/kg, 10 mg/kg, and 30 mg/kg, alongside the HCHF diet. Cognitive function was evaluated using the Y-maze test, while the levels of proinflammatory cytokines, oxidative stress, and the number glial fibrillary acidic protein (GFAP) positive cells were assessed in the hippocampi and hypothalamus. The consumption of the HCHF diet resulted in weight gain, hyperlipidemia, impaired glucose tolerance, cognitive decline, neuroinflammation, oxidative stress damage, and astrogliosis in rats. Although melatonin treatment did not demonstrate beneficial effects on blood glucose and lipid metabolism, it improved the impaired working memory caused by the HCHF diet. Melatonin exhibited a dose-dependent reduction of astrogliosis, neuroinflammation, and lipid peroxidation while restored superoxide dismutase in the hippocampus and hypothalamus of HCHF diet-treated rats. These findings provide evidence that melatonin inhibits astrocyte activation, thereby attenuating inflammation and minimizing oxidative stress damage induced by the HCHF diet.
C1 [Dorranipour, Davood; Pourjafari, Fahimeh; Hosseini, Mehran] Kerman Univ Med Sci, Sch Med, Dept Anat Sci, Kerman, Iran.
   [Malekpour-Afshar, Reza] Kerman Univ Med Sci, Pathol & Stem Cells Res Ctr, Kerman, Iran.
   [Basiri, Mohsen] Kerman Univ Med Sci, Neuropharmacol Inst, Neurosci Res Ctr, Kerman, Iran.
   [Hosseini, Mehran] Birjand Univ Med Sci, Cellular & Mol Res Ctr, Birjand, Iran.
C3 Kerman University of Medical Sciences; Kerman University of Medical
   Sciences; Kerman University of Medical Sciences; Birjand University of
   Medical Sciences
RP Hosseini, M (corresponding author), Kerman Univ Med Sci, Sch Med, Dept Anat Sci, Kerman, Iran.; Basiri, M (corresponding author), Kerman Univ Med Sci, Neuropharmacol Inst, Neurosci Res Ctr, Kerman, Iran.
EM basirim@yahoo.com; m.hosseini@kmu.ac.ir
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NR 64
TC 3
Z9 3
U1 1
U2 9
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0891-0618
EI 1873-6300
J9 J CHEM NEUROANAT
JI J. Chem. Neuroanat.
PD MAR
PY 2024
VL 136
AR 102389
DI 10.1016/j.jchemneu.2024.102389
EA JAN 2024
PG 10
WC Biochemistry & Molecular Biology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Neurosciences & Neurology
GA IL7L2
UT WOS:001166545800001
PM 38215799
DA 2025-06-11
ER

PT J
AU Schaakxs, R
   Wielaard, I
   Verhoeven, JE
   Beekman, ATF
   Penninx, BWJH
   Comijs, HC
AF Schaakxs, Roxanne
   Wielaard, Ilse
   Verhoeven, Josine E.
   Beekman, Aartjan T. F.
   Penninx, Brenda W. J. H.
   Comijs, Hannie C.
TI Early and recent psychosocial stress and telomere length in older adults
SO INTERNATIONAL PSYCHOGERIATRICS
LA English
DT Article
DE psychosocial stress; childhood abuse; negative life events; loneliness;
   cellular aging; telomere length; telomere shortening
ID ADVERSE CHILDHOOD EXPERIENCES; LATE-LIFE DEPRESSION; METABOLIC SYNDROME;
   HEALTH; LONELINESS; MORTALITY; DISEASE; CANCER; RISK; INFLAMMATION
AB Background: Psychosocial stress has been associated with an increased risk for mental and somatic health problems across the life span. Some studies in younger adults linked this to accelerated cellular aging, indexed by shortened telomere length (TL). In older adults, the impact of psychosocial stress on TL may be different due to the lifetime exposure to competing causes of TL-shortening. This study aims to assess whether early and recent psychosocial stressors (childhood abuse, childhood adverse events, recent negative life events, and loneliness) were associated with TL in older adults.
   Methods: Data were from the Netherlands Study of Depression in Older Persons (NESDO) in which psychosocial stressors were measured in 496 persons aged 60 and older (mean age 70.6 (SD 7.4) years) during a face-to-face interview. Leukocyte TL was determined using fasting blood samples by performing quantitative polymerase chain reaction (qPCR) and was expressed in base pairs (bp).
   Results: Multiple regression analyses, adjusted for age, sex, and chronic diseases, showed that childhood abuse, recent negative life events and loneliness were unrelated to TL. Only having experienced any childhood adverse event was weakly but significantly negatively associated with TL.
   Conclusions: Our findings did not consistently confirm our hypothesis that psychosocial stress is associated with shorter TL in older adults. Healthy survivorship or other TL-damaging factors such as somatic health problems seem to dominate a potential effect of psychosocial stress on TL in older adults.
C1 Vrije Univ Amsterdam Med Ctr, Dept Psychiat, POB 74077, NL-1070 BB Amsterdam, Netherlands.
   Vrije Univ Amsterdam Med Ctr, EMGO Inst Hlth & Care Res, POB 74077, NL-1070 BB Amsterdam, Netherlands.
C3 Vrije Universiteit Amsterdam; VU UNIVERSITY MEDICAL CENTER; Vrije
   Universiteit Amsterdam; VU UNIVERSITY MEDICAL CENTER
RP Schaakxs, R (corresponding author), POB 74077, NL-1070 BB Amsterdam, Netherlands.
EM r.schaakxs@ggzingeest.nl
RI Beekman, Aartjan T./LUZ-6919-2024; Penninx, Brenda/S-7627-2017
CR [Anonymous], 2000, DIAGN STAT MAN MENT
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NR 40
TC 36
Z9 37
U1 0
U2 35
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
SN 1041-6102
EI 1741-203X
J9 INT PSYCHOGERIATR
JI Int. Psychogeriatr.
PD MAR
PY 2016
VL 28
IS 3
BP 405
EP 413
DI 10.1017/S1041610215001155
PG 9
WC Psychology, Clinical; Geriatrics & Gerontology; Gerontology; Psychiatry;
   Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Geriatrics & Gerontology; Psychiatry
GA DF8TW
UT WOS:000371633500008
PM 26265356
OA hybrid
DA 2025-06-11
ER

PT J
AU Sarrafzadegan, N
   Gharipour, M
   Ramezani, MA
   Rabiei, K
   Zolfaghar, B
   Tavassoli, AA
   Boshtam, M
   Zarfeshani, S
   Khosravi, A
   Yousefi, A
AF Sarrafzadegan, Nizal
   Gharipour, Mojgan
   Ramezani, Mohammad Arash
   Rabiei, Katayoun
   Zolfaghar, Behzad
   Tavassoli, Ali Akbar
   Boshtam, Maryam
   Zarfeshani, Sonia
   Khosravi, Alireza
   Yousefi, Alireza
TI Metabolic syndrome and health-related quality of life in Iranian
   population
SO JOURNAL OF RESEARCH IN MEDICAL SCIENCES
LA English
DT Article
DE Metabolic syndrome; Quality of life; General population
ID HEART PROGRAM; OBESITY; DISEASE; HYPERTENSION; IMPACT; PREVALENCE;
   MORTALITY; WOMEN
AB BACKGROUND: To investigate the association between Metabolic syndrome (MetS) and Health related quality of life (QoL) in Iranian population.
   METHODS: We used data from the post-intervention phase of Isfahan Healthy Heart Program (IHHP), a community trial for cardiovascular disease (CVD) prevention and control. We recruited 9570 healthy adults, aged >= 19 years who were randomly selected using multistage random sampling method. World Health Organization QoL questionnaire (WHO-QOL-BREF) which contains 26 items was used to assess QoL. It assesses four domains of QoL; Physical health, Psychological health, Social relationship and Environmental issues. MetS was defined based on ATP III criteria.
   RESULTS: The mean age of participants was 38.8 +/- 15.6 years (mean +/- SD) and the prevalence of MetS was 22.5%. From all participant 18.2% were illiterate and 13.2% had university educational level. Two way multivariate analyses of co-variance (MANCOVA) test after adjusting age showed significant difference between women with and without Mets in regard to physical health and social relations domains, while none of QoL domains was different in men with Mets in comparison to men without it.
   CONCLUSIONS: After adjusting the role of socio-demographic factors as components of QoL score, no association was observed between QoL domains and MetS in men, while only social relations and physical health scores were higher in women with Mets compared to those without Mets. Other variety of health-related QoL assessment tools or definitions of MetS may show different relationship in the Iranian socio-cultural context.
C1 [Tavassoli, Ali Akbar] Isfahan Univ Med Sci, Sch Med, Esfahan, Iran.
   [Sarrafzadegan, Nizal; Gharipour, Mojgan; Ramezani, Mohammad Arash; Rabiei, Katayoun; Boshtam, Maryam; Zarfeshani, Sonia; Khosravi, Alireza] Isfahan Univ Med Sci, Isfahan Cardiovasc Res Inst, Esfahan, Iran.
   [Zolfaghar, Behzad] Isfahan Univ Med Sci, Dept Pharmacognosy, Esfahan, Iran.
   [Yousefi, Alireza] Isfahan Univ Med Sci, Med Educ Res Ctr, Esfahan, Iran.
C3 Isfahan University of Medical Sciences; Isfahan University of Medical
   Sciences; Isfahan University of Medical Sciences; Isfahan University of
   Medical Sciences
RP Tavassoli, AA (corresponding author), Isfahan Univ Med Sci, Sch Med, Esfahan, Iran.
EM nizal.sarrafzadegan@gmail.com
RI Tavassoli, Aliakbar/W-5013-2017; Rabiei, Katayoun/D-2226-2011; Ramezani,
   Mohammad Arash/AAY-1039-2021; Gharipour, mojgan/R-3486-2019; Boshtam,
   Maryam/W-7910-2019; Khosravi Farsani, Alireza/B-7453-2018; zolfaghari,
   behzad/E-6038-2016; Sarrafzadegan, Nizal/V-5826-2017
OI Khosravi Farsani, Alireza/0000-0003-0736-2090; Gharipour,
   Mojgan/0000-0001-7397-1172; zolfaghari, behzad/0000-0001-7087-2590;
   Sarrafzadegan, Nizal/0000-0002-8352-0540; rabiei,
   katayoun/0000-0001-5621-7960; Tavassoli, Aliakbar/0000-0001-9382-1403
FU Iranian Budget and Planning Organization [31309304]; Deputy for Health
   of the Iranian Ministry of Health and Medical Education; Iranian Heart
   Foundation
FX This program was supported by a grant (No. 31309304) from the Iranian
   Budget and Planning Organization, as well as the Deputy for Health of
   the Iranian Ministry of Health and Medical Education and Iranian Heart
   Foundation. It was conducted by Isfahan Cardiovascular Institute with
   the collaboration of Isfahan Provincial Health Center, both affiliated
   to Isfahan University of Medical Sciences.
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NR 40
TC 22
Z9 27
U1 0
U2 4
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, 400059, INDIA
SN 1735-1995
EI 1735-7136
J9 J RES MED SCI
JI J. Res. Med. Sci.
PD MAR
PY 2011
VL 16
IS 3
BP 254
EP 261
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 745TD
UT WOS:000289188100003
PM 22091241
DA 2025-06-11
ER

PT J
AU Grandl, G
   Wolfrum, C
AF Grandl, Gerald
   Wolfrum, Christian
TI Hemostasis, endothelial stress, inflammation, and the metabolic syndrome
SO SEMINARS IN IMMUNOPATHOLOGY
LA English
DT Review
DE Obesity; Metabolic syndrome; Type 2 diabetes; Hemostasis; Platelets;
   Coagulation; Endothelial stress; Nitric oxide; NO; Reactive oxygen
   species; ROS; Inflammation
ID NITRIC-OXIDE SYNTHASE; L-ARGININE SUPPLEMENTATION; DIET-INDUCED OBESITY;
   INSULIN-MEDIATED VASODILATION; PROTEIN-KINASE-C; DIABETES-MELLITUS;
   OXIDATIVE STRESS; GLUCOSE-UPTAKE; IN-VIVO; ASYMMETRIC DIMETHYLARGININE
AB Obesity and the metabolic syndrome (MS) are two of the pressing healthcare problems of our time. The MS is defined as increased abdominal obesity in concert with elevated fasting glucose levels, insulin resistance, elevated blood pressure, and plasma lipids. It is a key risk factor for type 2 diabetes mellitus (T2DM) and for cardiovascular complications and mortality. Here, we review work demonstrating that various aspects of coagulation and hemostasis, as well as vascular reactivity and function, become impaired progressively during chronic ingestion of a western diet, but also acutely after meals. We outline that both T2DM and cardiovascular disease should be viewed as inflammatory diseases and describe that chronic overload of free fatty acids and glucose can trigger inflammatory pathways directly or via increased production of ROS. We propose that since endothelial stress and increases in platelet activity precede inflammation and overt symptoms of the MS, they are likely the first hit. This suggests that endothelial activation and insulin resistance are probably causative in the observed chronic low-level metabolic inflammation, and thus both metabolic and cardiovascular complications linked to consumption of a western diet.
C1 [Grandl, Gerald; Wolfrum, Christian] Swiss Fed Inst Technol, Inst Food Nutr & Hlth, Schwerzenbach, Switzerland.
   [Grandl, Gerald] Helmholtz Zentrum Munchen, Inst Diabet & Obes, Parkring 13, D-85748 Garching, Germany.
C3 Swiss Federal Institutes of Technology Domain; ETH Zurich; Helmholtz
   Association; Helmholtz-Center Munich - German Research Center for
   Environmental Health
RP Grandl, G (corresponding author), Swiss Fed Inst Technol, Inst Food Nutr & Hlth, Schwerzenbach, Switzerland.; Grandl, G (corresponding author), Helmholtz Zentrum Munchen, Inst Diabet & Obes, Parkring 13, D-85748 Garching, Germany.
EM gerald.grandl@helmholtz-muenchen.de
OI Wolfrum, Christian/0000-0002-3862-6805; Grandl,
   Gerald/0000-0003-4456-1988
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NR 118
TC 227
Z9 253
U1 2
U2 25
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1863-2297
EI 1863-2300
J9 SEMIN IMMUNOPATHOL
JI Semin. Immunopathol.
PD FEB
PY 2018
VL 40
IS 2
SI SI
BP 215
EP 224
DI 10.1007/s00281-017-0666-5
PG 10
WC Immunology; Pathology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Pathology
GA FV9BD
UT WOS:000424880800007
PM 29209827
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Díaz-Flores, M
   Cruz, M
   Duran-Reyes, G
   Munguia-Miranda, C
   Loza-Rodríguez, H
   Pulido-Casas, E
   Torres-Ramírez, N
   Gaja-Rodriguez, O
   Kumate, J
   Baiza-Gutman, LA
   Hernández-Saavedra, D
AF Diaz-Flores, Margarita
   Cruz, Miguel
   Duran-Reyes, Genoveva
   Munguia-Miranda, Catarina
   Loza-Rodriguez, Hilda
   Pulido-Casas, Evelyn
   Torres-Ramirez, Nayeli
   Gaja-Rodriguez, Olga
   Kumate, Jesus
   Arturo Baiza-Gutman, Luis
   Hernandez-Saavedra, Daniel
TI Oral supplementation with glycine reduces oxidative stress in patients
   with metabolic syndrome, improving their systolic blood pressure
SO CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
LA English
DT Article
DE glycine; cardiovascular disease; metabolic syndrome; oxidative stress;
   pharmacology; therapeutics
ID GLUCOSE-6-PHOSPHATE-DEHYDROGENASE DEFICIENCY; OXIDANT STRESS;
   GLUTATHIONE; CYTOKINES; PROTEINS; GLUCOSE; CELLS
AB Reactive oxygen species derived from abdominal fat and uncontrolled glucose metabolism are contributing factors to both oxidative stress and the development of metabolic syndrome (MetS). This study was designed to evaluate the effects of daily administration of an oral glycine supplement on antioxidant enzymes and lipid peroxidation in MetS patients. The study included 60 volunteers: 30 individuals that were supplemented with glycine (15 g/day) and 30 that were given a placebo for 3 months. We analysed thiobarbituric acid reactive substances (TBARS) and S-nitrosohemoglobin (SNO-Hb) in plasma; the enzymatic activities of glucose-6-phosphate dehydrogenase (G6PD), superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPX) in erythrocytes; and the expression of CAT, GPX, and SOD2 in leukocytes. Individuals treated with glycine showed a 25% decrease in TBARS compared with the placebo-treated group. Furthermore, there was a 20% reduction in SOD-specific activity in the glycine-treated group, which correlated with SOD2 expression. G6PD activity and SNO-Hb levels increased in the glycine-treated male group. Systolic blood pressure (SBP) also showed a significant decrease in the glycine-treated men (p = 0.043). Glycine plays an important role in balancing the redox reactions in the human body, thus protecting against oxidative damage in MetS patients.
C1 [Diaz-Flores, Margarita; Cruz, Miguel; Duran-Reyes, Genoveva; Munguia-Miranda, Catarina; Loza-Rodriguez, Hilda; Pulido-Casas, Evelyn; Torres-Ramirez, Nayeli; Gaja-Rodriguez, Olga; Hernandez-Saavedra, Daniel] IMSS, CMN Siglo 21, Unidad Invest Med Bioquim, Hosp Especialidades Piso 1Er, Mexico City 06725, DF, Mexico.
   [Kumate, Jesus] Fdn IMSS, Mexico City 06600, DF, Mexico.
   [Arturo Baiza-Gutman, Luis] Univ Nacl Autonoma Mexico, Unidad Morfofisiol FES IZTACALA, Lab Biol Desarrollo, Mexico City, DF, Mexico.
C3 Instituto Mexicano del Seguro Social; Universidad Nacional Autonoma de
   Mexico
RP Hernández-Saavedra, D (corresponding author), Univ Colorado, Dev Lung Biol & Cardiovasc Pulm Res Labs Crit Car, Dept Pediat, Anschutz Med Campus, Aurora, CO 80045 USA.
EM daniel.hernandez-saavedra@ucdenver.edu
RI Hernandez-Saavedra, Daniel/AGO-1286-2022; Baiza-Gutman,
   Luis/H-9160-2019; Ramírez, Nayeli/AAZ-4050-2020; Cruz Lopez,
   Miguel/O-5493-2018
OI DIAZ-FLORES, MARGARITA/0000-0001-9764-2701; LOZA RODRIGUEZ,
   HILDA/0000-0003-3281-4589; Hernandez-Saavedra,
   Daniel/0000-0003-1449-944X; Torres-Ramirez, Nayeli/0000-0002-7515-9740;
   Baiza-Gutman, Luis Arturo/0000-0002-3669-4185; Cruz Lopez,
   Miguel/0000-0001-9985-6172
FU National Council of Science and Technology (CONACyT) [14-412, 56041];
   Fomento de la Investigacion (FOFOI) [785-092]; Mexican Social Security
   Institute Foundation (Fundacion IMSS A.C.); Fundacion Gonzalo Rio
   Arronte I.A.P.
FX We would like to thank Reyna Sanchez-Barrera, M. D. for the recruitment
   and follow-up of the patients, as well as all the members of the Medical
   Research Unit in Biochemistry involved in the sample processing. This
   work was supported by grants from the National Council of Science and
   Technology (CONACyT #14-412 to M. C., and 56041 to D. H. S.), Fomento de
   la Investigacion (FOFOI; 785-092 to DHS), Mexican Social Security
   Institute Foundation (Fundacion IMSS A.C.), and Fundacion Gonzalo Rio
   Arronte I.A.P.
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NR 37
TC 60
Z9 65
U1 2
U2 39
PU CANADIAN SCIENCE PUBLISHING
PI OTTAWA
PA 65 AURIGA DR, SUITE 203, OTTAWA, ON K2E 7W6, CANADA
SN 0008-4212
EI 1205-7541
J9 CAN J PHYSIOL PHARM
JI Can. J. Physiol. Pharmacol.
PD OCT
PY 2013
VL 91
IS 10
BP 855
EP 860
DI 10.1139/cjpp-2012-0341
PG 6
WC Pharmacology & Pharmacy; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Physiology
GA 221BV
UT WOS:000324633200012
PM 24144057
DA 2025-06-11
ER

PT J
AU Panov, A
   Mayorov, V
   Dikalov, S
AF Panov, Alexander
   Mayorov, Vladimir, I
   Dikalov, Sergey
TI Metabolic Syndrome and β-Oxidation of Long-Chain Fatty Acids in the
   Brain, Heart, and Kidney Mitochondria
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE metabolic syndrome; kidney; heart; brain mitochondria; beta-oxidation;
   long-chain fatty acids; oxidative stress; human postembryonic
   ontogenesis
ID 3RD NATIONAL-HEALTH; FREE-RADICAL THEORY; GENDER-DIFFERENCES;
   OXYGEN-CONSUMPTION; NITRIC-OXIDE; ENDURANCE EXERCISE; HYDROGEN-PEROXIDE;
   ENERGY-METABOLISM; THRIFTY GENOTYPE; SEX-DIFFERENCES
AB We present evidence that metabolic syndrome (MetS) represents the postreproductive stage of the human postembryonic ontogenesis. Accordingly, the genes governing this stage experience relatively weak evolutionary selection pressure, thus representing the metabolic phenotype of distant ancestors with beta-oxidation of long-chain fatty acids (FAs) as the primary energy source. Mitochondria oxidize at high-rate FAs only when succinate, glutamate, or pyruvate are present. The heart and brain mitochondria work at a wide range of functional loads and possess an intrinsic inhibition of complex II to prevent oxidative stress at periods of low functional activity. Kidney mitochondria constantly work at a high rate and lack inhibition of complex II. We suggest that in people with MetS, oxidative stress is the central mechanism of the heart and brain pathologies. Oxidative stress is a secondary pathogenetic mechanism in the kidney, while the primary mechanisms are kidney hypoxia caused by persistent hyperglycemia and hypertension. Current evidence suggests that most of the nongenetic pathologies associated with MetS originate from the inconsistencies between the metabolic phenotype acquired after the transition to the postreproductive stage and excessive consumption of food rich in carbohydrates and a sedentary lifestyle.
C1 [Panov, Alexander; Mayorov, Vladimir, I] Mercer Univ, Dept Biomed Sci, Sch Med, Macon, GA 31201 USA.
   [Dikalov, Sergey] Vanderbilt Univ, Div Clin Pharmacol, Med Ctr, Nashville, TN 37232 USA.
C3 Mercer University; Vanderbilt University
RP Panov, A (corresponding author), Mercer Univ, Dept Biomed Sci, Sch Med, Macon, GA 31201 USA.
EM alexander.panov55@gmail.com; Sergey.dikalov@vanderbilt.edu
RI Panov, Alexander/K-7590-2017; Dikalov, Sergey/C-6600-2016
OI Dikalov, Sergey/0000-0003-2976-6184
FU National Institutes of Health [R01HL144943, RO1HL157583]; Navicent
   Health Foundation grant (Mercer University School of Medicine)
FX This work was supported by funding from the National Institutes of
   Health (R01HL144943 and RO1HL157583) and Navicent Health Foundation
   grant (Mercer University School of Medicine).
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NR 119
TC 24
Z9 24
U1 2
U2 13
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD APR
PY 2022
VL 23
IS 7
AR 4047
DI 10.3390/ijms23074047
PG 19
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 0L4LG
UT WOS:000781446500001
PM 35409406
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Wolthusen, RPF
   Hass, J
   Walton, E
   Turner, JA
   Rössner, V
   Sponheim, SR
   Ho, BC
   Holt, DJ
   Gollub, RL
   Calhoun, V
   Ehrlich, S
AF Wolthusen, Rick P. F.
   Hass, Johanna
   Walton, Esther
   Turner, Jessica A.
   Roessner, Veit
   Sponheim, Scott R.
   Ho, Beng-Choon
   Holt, Daphne J.
   Gollub, Randy L.
   Calhoun, Vince
   Ehrlich, Stefan
TI Genetic underpinnings of left superior temporal gyrus thickness in
   patients with schizophrenia
SO WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
LA English
DT Article
DE genetics; imaging; schizophrenia; superior temporal gyrus; cortical
   thickness
ID GENOME-WIDE ASSOCIATION; HUMAN CEREBRAL-CORTEX; DATA QUALITY-CONTROL;
   METABOLIC SYNDROME; DIABETES-MELLITUS; GLUCOSE-HOMEOSTASIS; CORTICAL
   THICKNESS; PLANUM TEMPORALE; VOLUME REDUCTION; BRAIN
AB Objectives. Schizophrenia is a highly disabling psychiatric disorder with a heterogeneous phenotypic appearance. We aimed to further the understanding of some of the underlying genetics of schizophrenia, using left superior temporal gyrus (STG) grey matter thickness reduction as an endophenoptype in a genome-wide association (GWA) study. Methods. Structural magnetic resonance imaging (MRI) and genetic data of the Mind Clinical Imaging Consortium (MCIC) study of schizophrenia were used to analyse the interaction effects between 1,067,955 single nucleotide polymorphisms (SNPs) and disease status on left STG thickness in 126 healthy controls and 113 patients with schizophrenia. We next used a pathway approach to detect underlying pathophysiological pathways that may be related to schizophrenia. Results. No SNP by diagnosis interaction effect reached genome-wide significance (5 x 10(-8)) in our GWA study, but 10 SNPs reached P-values less than 10(-6). The most prominent pathways included those involved in insulin, calcium, PI3K-Akt and MAPK signalling. Conclusions. Our strongest findings in the GWA study and pathway analysis point towards an involvement of glucose metabolism in left STG thickness reduction in patients with schizophrenia only. These results are in line with recently published studies, which showed an increased prevalence of psychosis among patients with metabolic syndrome-related illnesses including diabetes.
C1 [Wolthusen, Rick P. F.; Hass, Johanna; Walton, Esther; Roessner, Veit; Ehrlich, Stefan] Tech Univ Dresden, Fac Med Carl Gustav Carus, Dept Child & Adolescent Psychiat, Translat Dev Neurosci Sect, D-01062 Dresden, Germany.
   [Wolthusen, Rick P. F.; Holt, Daphne J.; Gollub, Randy L.; Ehrlich, Stefan] Massachusetts Gen Hosp, MGH MIT HMS Martinos Ctr Biomed Imaging, Charlestown, MA USA.
   [Wolthusen, Rick P. F.; Holt, Daphne J.; Gollub, Randy L.; Ehrlich, Stefan] Massachusetts Gen Hosp, Dept Psychiat, Boston, MA 02114 USA.
   [Wolthusen, Rick P. F.] Harvard Univ, Sch Med, Div Med Sci, Boston, MA USA.
   [Hass, Johanna] Univ Tubingen, Inst Trop Med, Tubingen, Germany.
   [Walton, Esther] Kings Coll London, Inst Psychiat Psychol & Neurosci, London WC2R 2LS, England.
   [Turner, Jessica A.] Georgia State Univ, Dept Psychol, Atlanta, GA 30303 USA.
   [Turner, Jessica A.] Georgia State Univ, Inst Neurosci, Atlanta, GA 30303 USA.
   [Sponheim, Scott R.] Univ Minnesota, Dept Psychiat, Minneapolis VA Hlth Care Syst, Minneapolis, MN 55455 USA.
   [Ho, Beng-Choon] Univ Iowa, Dept Psychiat, Carver Coll Med, Iowa City, IA 52242 USA.
   [Holt, Daphne J.; Gollub, Randy L.] Harvard Univ, Sch Med, Dept Psychiat, Boston, MA 02115 USA.
   [Calhoun, Vince] Univ New Mexico, Dept Elect & Comp Engn, Albuquerque, NM 87131 USA.
   [Calhoun, Vince] Mind Res Network, Albuquerque, NM USA.
C3 Technische Universitat Dresden; Harvard University; Harvard University
   Medical Affiliates; Massachusetts General Hospital; Harvard University;
   Harvard University Medical Affiliates; Massachusetts General Hospital;
   Harvard University; Harvard Medical School; Eberhard Karls University of
   Tubingen; University of London; King's College London; University System
   of Georgia; Georgia State University; University System of Georgia;
   Georgia State University; University of Minnesota System; University of
   Minnesota Twin Cities; US Department of Veterans Affairs; Veterans
   Health Administration (VHA); Minneapolis VA Health Care System;
   University of Iowa; Harvard University; Harvard Medical School;
   University of New Mexico; Lovelace Respiratory Research Institute; Mind
   Research Network
RP Wolthusen, RPF (corresponding author), Athinoula A Martinos Ctr Biomed Imaging, Bldg 149,13th St,Room 2611, Charlestown, MA 02129 USA.
EM RWolthusen@mgh.harvard.edu
RI Ho, Beng-Choon/D-6959-2011; Ehrlich, Stefan/ABB-4650-2020; Walton,
   Esther/P-9832-2019; Roessner, Veit/AAQ-8760-2020; Turner,
   Jessica/H-7282-2015; Calhoun, Vince/ACN-9399-2022; Wolthusen,
   Rick/NHQ-6604-2025; Holt, Daphne/O-2201-2017; Sponheim,
   Scott/J-3857-2017; Calhoun, Vince/H-7146-2013
OI Ehrlich, Stefan/0000-0003-2132-4445; Sponheim,
   Scott/0000-0002-2782-0856; Walton, Esther/0000-0002-0935-2200; Calhoun,
   Vince/0000-0001-9058-0747; Roessner, Veit/0000-0002-1873-7081; Holt,
   Daphne J./0000-0002-6428-9603; Ho, Beng-Choon/0000-0003-3976-1555;
   Gollub, Randy L./0000-0002-9434-4044
FU National Institutes of Health [NIH/NCRR P41RR14075]; Department of
   Energy [DE-FG02-99ER62764]; MIND Research Network, Morphometry
   Biomedical Informatics Research Network (BIRN) [1U24, RR021382A];
   Function BIRN [U24RR021992-01, NIH.NCRR MO1 RR025758-01, NIMH
   1RC1MH089257]; NARSAD Young Investigator Grant; Deutsche
   Forschungsgemeinschaft
FX This work was supported by the National Institutes of Health (NIH/NCRR
   P41RR14075), Department of Energy (DE-FG02-99ER62764), MIND Research
   Network, Morphometry Biomedical Informatics Research Network (BIRN)
   (1U24, RR021382A), Function BIRN (U24RR021992-01, NIH.NCRR MO1
   RR025758-01, NIMH 1RC1MH089257 to VDC), the NARSAD Young Investigator
   Grant (to SE), and the Deutsche Forschungsgemeinschaft (Research
   Fellowship to SE). The funders had no role in study design, data
   collection and analysis, decision to publish, or preparation of the
   manuscript.
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NR 84
TC 6
Z9 8
U1 0
U2 6
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1562-2975
EI 1814-1412
J9 WORLD J BIOL PSYCHIA
JI World J. Biol. Psychiatry
PY 2015
VL 16
IS 6
BP 430
EP 440
DI 10.3109/15622975.2015.1062915
PG 11
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychiatry
GA CR4TJ
UT WOS:000361331700008
PM 26249676
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Wang, X
   Hattori, Y
   Satoh, H
   Iwata, C
   Banba, N
   Monden, T
   Uchida, K
   Kamikawa, Y
   Kasai, K
AF Wang, Xi
   Hattori, Yoshiyuki
   Satoh, Hiroko
   Iwata, Chigusa
   Banba, Nobuyuki
   Monden, Tsuyoshi
   Uchida, Kohsuke
   Kamikawa, Yuichiro
   Kasai, Kikuo
TI Tetrahydrobiopterin prevents endothelial dysfunction and restores
   adiponectin levels in rats
SO EUROPEAN JOURNAL OF PHARMACOLOGY
LA English
DT Article
DE tetrahydrobiopterin; endothelial function; adiponectin; metabolic
   syndrome
ID OXIDATIVE STRESS; INSULIN; BIOPTERIN
AB Oxidative stress induces endothelial dysfunction and hypoadiponectinemia. We previously reported that supplementation with tetrahydrobiopterin (BH4), one of the most potent naturally occurring reducing agents and an essential cofactor of enzymatic NO synthase (NOS), ameliorates endothelial dysfunction and reverses hypoadiponectinemia as a result of oxidative stress in rats. To further confirm this hypothesis, we investigated the effects of treatment with BH4 on endothelium-dependent relaxation and adiponectin levels during oxidative stress in fructose-fed rats, which provide an animal model for the metabolic syndrome. Ingestion of a fructose diet for 8 weeks significantly impaired endothelium-dependent arterial relaxation in aortic strips and decreased plasma adiponectin levels, as well as adiponectin mRNA levels within adipose tissue. However, oral supplementation with BH4 (10 mg/kg day) over the final 4 weeks leads to a significant partial reversal of impaired endothelium-dependent arterial relaxation, as well as normalization of plasma adiponectin and fat adiponectin mRNA levels. Moreover, BH4 treatment of the fructose-fed rats significantly reduced the lipid peroxidation content of aorta, heart, liver, and kidney tissues, which were increased in fructose-fed rats. This effect of BH4 treatment may be due to its function as a cofactor for eNOS, as well as its anti-oxidative effects. Thus, BH4 might show promise for the treatment of oxidative stress-induced disorders, including the metabolic syndrome. (c) 2006 Elsevier B. V. All rights reserved.
C1 Dokkyo Univ, Sch Med, Dept Endocrinol & Metab, Mibu, Tochigi 32102, Japan.
   Dokkyo Univ, Sch Med, Dept Pharmacol, Mibu, Tochigi 32102, Japan.
C3 Dokkyo Medical University; Dokkyo Medical University
RP Hattori, Y (corresponding author), Dokkyo Univ, Sch Med, Dept Endocrinol & Metab, Mibu, Tochigi 32102, Japan.
EM yhattori@dokkyomed.ac.jp
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NR 15
TC 30
Z9 35
U1 0
U2 1
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0014-2999
J9 EUR J PHARMACOL
JI Eur. J. Pharmacol.
PD JAN 19
PY 2007
VL 555
IS 1
BP 48
EP 53
DI 10.1016/j.ejphar.2006.10.017
PG 6
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 133JF
UT WOS:000244008500008
PM 17098227
DA 2025-06-11
ER

PT J
AU Liaw, FY
   Kao, TW
   Hsueh, JT
   Chan, YH
   Chang, YW
   Chen, WL
AF Liaw, Fang-Yih
   Kao, Tung-Wei
   Hsueh, Ju-Ting
   Chan, Yi-Hsin
   Chang, Yaw-Wen
   Chen, Wei-Liang
TI Exploring the Link between the Components of Metabolic Syndrome and the
   Risk of Depression
SO BIOMED RESEARCH INTERNATIONAL
LA English
DT Article
ID 3RD NATIONAL-HEALTH; INSULIN-RESISTANCE; MAJOR DEPRESSION; ASSOCIATION;
   PREVALENCE; HEART; METAANALYSIS; CHOLESTEROL; NEUROENDOCRINE;
   SENSITIVITY
AB Background. Metabolic syndrome (MetS) has been reported with an increased risk of depression. MetS was also associated with insulin resistance. This study aimed to evaluate whether MetS components might contribute to depression in participants with insulin resistance (IR) or not. Methods. This study included 3,331 participants >= 18 years in the NHANES 2009-2010. Depressive symptoms were assessed using the Patient Health Questionnaire-9 (PHQ-9). MetS components were measured using blood chemistry and body measurements. IR was identified using the homeostasis model assessment method. Results. Predicted PHQ-9 scores significantly increased as the number of MetS components increased in patients with IR. The adjusted.. coefficients of the predicted PHQ-9 score with 2, 4, and 5 MetS components were 1.803, 2.081, and 3.048, respectively (P for trend < 0.05). Low HDL-C levels were significantly associated with higher predicted total PHQ-9 scores in fully adjusted models in the IR group (P < 0.05). Conclusion. The results indicated that the presence of a greater number of components of MetS was significantly associated with higher predicted total PHQ-9 scores in participants with IR. Among the components of MetS, the most apparent association was observed between low HDL and higher predicted total PHQ-9 scores.
C1 [Liaw, Fang-Yih; Kao, Tung-Wei; Hsueh, Ju-Ting; Chan, Yi-Hsin; Chang, Yaw-Wen; Chen, Wei-Liang] Natl Def Med Ctr, Triserv Gen Hosp, Dept Family & Community Med, Div Family Med, Taipei, Taiwan.
   [Liaw, Fang-Yih; Kao, Tung-Wei; Hsueh, Ju-Ting; Chang, Yaw-Wen; Chen, Wei-Liang] Natl Def Med Ctr, Triserv Gen Hosp, Dept Family & Community Med, Div Geriatr Med, Taipei, Taiwan.
   [Chan, Yi-Hsin; Chang, Yaw-Wen; Chen, Wei-Liang] Natl Def Med Ctr, Grad Inst Med Sci, Taipei, Taiwan.
C3 National Defense Medical Center; Tri-Service General Hospital; National
   Defense Medical Center; Tri-Service General Hospital; National Defense
   Medical Center
RP Chen, WL (corresponding author), Natl Def Med Ctr, Triserv Gen Hosp, Dept Family & Community Med, Div Family Med, Taipei, Taiwan.
EM weiliang0508@gmail.com
RI Chan, Yi-Hsin/ABA-5023-2021; Chang, Yaw-Wen/AAF-2630-2020
OI Chang, Yaw-Wen/0000-0002-8436-0518
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NR 41
TC 11
Z9 13
U1 0
U2 3
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2314-6133
EI 2314-6141
J9 BIOMED RES INT
JI Biomed Res. Int.
PY 2015
VL 2015
AR 586251
DI 10.1155/2015/586251
PG 8
WC Biotechnology & Applied Microbiology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Research & Experimental Medicine
GA CZ2NJ
UT WOS:000366941600001
PM 26770976
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Li, YY
   Chen, HY
   Wang, JH
   Wang, JB
   Niu, X
   Wang, C
   Qin, DD
   Li, F
   Wang, YM
   Xiong, J
   Liu, SY
   Huang, LQ
   Zhang, X
   Gao, F
   Gao, DD
   Fan, MX
   Xiao, X
   Wang, ZH
AF Li, Yiyi
   Chen, Hongyu
   Wang, Jianhao
   Wang, Jiabei
   Niu, Xuan
   Wang, Chao
   Qin, Dongdong
   Li, Fang
   Wang, Yamei
   Xiong, Jing
   Liu, Songyan
   Huang, Liqin
   Zhang, Xi
   Gao, Feng
   Gao, Dandan
   Fan, Mingxia
   Xiao, Xuan
   Wang, Zhi-Hao
TI Inflammation-activated C/EBPβ mediates high-fat diet-induced
   depression-like behaviors in mice
SO FRONTIERS IN MOLECULAR NEUROSCIENCE
LA English
DT Article
DE high-fat diet; depression; transcription factor; C/EBP beta;
   inflammation; BDNF
ID NEUROTROPHIC FACTOR; STRESS; BRAIN; RECEPTOR; TRKB; TRANSCRIPTION;
   PREVALENCE; DEFICIENCY; EXPRESSION; SYMPTOMS
AB Depression, one of the most common causes of disability, has a high prevalence rate in patients with metabolic syndrome. Type 2 diabetes patients are at an increased risk for depression. However, the molecular mechanism coupling diabetes to depressive disorder remains largely unknown. Here we found that the neuroinflammation, associated with high-fat diet (HFD)-induced diabetes and obesity, activated the transcription factor CCAAT/enhancer binding protein beta (C/EBP beta) in hippocampal neurons. This factor repressed brain-derived neurotrophic factor (BDNF) expression and caused depression-like behaviors in male mice. Besides, the loss of C/EBP beta expression in C/EBP beta heterozygous knockout male mice attenuated HFD-induced depression-like behaviors, whereas Thy1-C/EBP beta transgenic male mice (overexpressing C/EBP beta) showed depressive behaviors after a short-term HFD. Furthermore, HFD impaired synaptic plasticity and decreased surface expression of glutamate receptors in the hippocampus of wild-type (WT) mice, but not in C/EBP beta heterozygous knockout mice. Remarkably, the anti-inflammatory drug aspirin strongly alleviated HFD-elicited depression-like behaviors in neuronal C/EBP beta transgenic mice. Finally, the genetic delivery of BDNF or the pharmacological activation of the BDNF/TrkB signaling pathway by 7,8-dihydroxyflavone reversed anhedonia in a series of behavioral tests on HFD-fed C/EBP beta transgenic mice. Therefore, our findings aim to demonstrate that the inflammation-activated neuronal C/EBP beta promotes HFD-induced depression by diminishing BDNF expression.
C1 [Li, Yiyi; Chen, Hongyu; Wang, Jianhao; Wang, Jiabei; Niu, Xuan; Wang, Chao; Qin, Dongdong; Li, Fang; Wang, Yamei; Xiong, Jing; Liu, Songyan; Huang, Liqin; Zhang, Xi; Gao, Feng; Gao, Dandan; Wang, Zhi-Hao] Wuhan Univ, Dept Neurol, Renmin Hosp, Wuhan, Peoples R China.
   [Li, Yiyi; Chen, Hongyu; Wang, Jianhao; Wang, Jiabei; Niu, Xuan; Wang, Chao; Qin, Dongdong; Li, Fang; Wang, Yamei; Xiong, Jing; Liu, Songyan; Huang, Liqin; Zhang, Xi; Gao, Feng; Gao, Dandan; Wang, Zhi-Hao] Wuhan Univ, Ctr Neurodegenerat Dis Res, Renmin Hosp, Wuhan, Peoples R China.
   [Fan, Mingxia] Wuhan Univ, Anim Expt Ctr, Renmin Hosp, Wuhan, Peoples R China.
   [Xiao, Xuan] Wuhan Univ, Dept Ophthalmol, Renmin Hosp, Wuhan, Peoples R China.
C3 Wuhan University; Wuhan University; Wuhan University; Wuhan University
RP Wang, ZH (corresponding author), Wuhan Univ, Dept Neurol, Renmin Hosp, Wuhan, Peoples R China.; Wang, ZH (corresponding author), Wuhan Univ, Ctr Neurodegenerat Dis Res, Renmin Hosp, Wuhan, Peoples R China.; Fan, MX (corresponding author), Wuhan Univ, Anim Expt Ctr, Renmin Hosp, Wuhan, Peoples R China.; Xiao, X (corresponding author), Wuhan Univ, Dept Ophthalmol, Renmin Hosp, Wuhan, Peoples R China.
EM fanmingxia@whu.edu.cn; xiaoxuan1111@163.com; wangzh86@whu.edu.cn
RI Gao, Feng/ABD-6409-2021
FU National Natural Science Foundation of China; National Key Research
   Projects of China [82101479]; Hubei Province Special Project - Central
   Funds Guiding the Local Science and Technology Development
   [2021YFA1302400]; Wuhan University Specific Fund for Major School-level
   Internationalization Initiatives [2016ZYYD002];  [WHU-GJZDZX-PT02]
FX This work was supported by the National Natural Science Foundation of
   China (No. 82101479) to Z-HW, National Key Research Projects of China
   (No. 2021YFA1302400) to Z-HW, Hubei Province Special Project Supported
   by Central Funds Guiding the Local Science and Technology Development
   (No. 2016ZYYD002) to MF, and Wuhan University Specific Fund for Major
   School-level Internationalization Initiatives (No. WHU-GJZDZX-PT02) to
   XX.
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NR 50
TC 15
Z9 16
U1 5
U2 36
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1662-5099
J9 FRONT MOL NEUROSCI
JI Front. Molec. Neurosci.
PD DEC 12
PY 2022
VL 15
AR 1068164
DI 10.3389/fnmol.2022.1068164
PG 23
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 7I3SU
UT WOS:000903812500001
PM 36578534
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Hamer, M
   Steptoe, A
AF Hamer, Mark
   Steptoe, Andrew
TI Cortisol Responses to Mental Stress and Incident Hypertension in Healthy
   Men and Women
SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Article
ID BLOOD-PRESSURE; PSYCHOLOGICAL STRESS; PLASMA-CORTISOL; RISK-FACTORS;
   ADRENOCORTICAL RESPONSES; METABOLIC SYNDROME; PITUITARY; INSULIN;
   OBESITY
AB Context: Heightened cardiovascular responses to mental stressors are associated with future risk of hypertension. The role of cortisol, a key stress hormone produced by the hypothalamic-pituitary-adrenal axis, remains unclear.
   Objective: Our objective was to examine the association between cortisol responses to laboratory-induced mental stress and incident hypertension.
   Design and Setting: This was a prospective substudy of the Whitehall II cohort with 3 years follow-up of an occupational cohort.
   Participants: Participants included 479 initially healthy men and women (mean age, 62.7 +/- 5.6 yr), without history or objective signs of cardiovascular disease or hypertension at study entry.
   Intervention: At the baseline assessment, salivary cortisol was measured in response to mental stressors, consisting of a 5-min Stroop task and a 5-min mirror tracing task.
   Main Outcome Measures: Blood pressure was measured at study entry and at 3 yr follow-up for the determination of hypertension.
   Results: There was considerable variation in the cortisol stress response, with approximately 40% of the sample responding to the stress tasks with an increase in cortisol of at least 1 mmol/liter. Over the 3 yr follow-up, 15.9% of the sample developed hypertension. There was an association between cortisol stress reactivity (per SD) and incident hypertension (odds ratio = 1.59; 95% confidence interval = 1.17-2.17) after adjustments for age, sex, resting cortisol, blood pressure at study entry, employment grade, smoking, body mass index, glycated hemoglobin, use of statins, and blood lipids.
   Conclusion: These data support the notion that cortisol reactivity, an index of hypothalamic-pituitary-adrenal function, is one of the possible mechanisms through which psychosocial stress may influence the risk of hypertension. (J Clin Endocrinol Metab 97: E29-E34, 2012)
C1 [Hamer, Mark; Steptoe, Andrew] UCL, Dept Epidemiol & Publ Hlth, London WC1E 6BT, England.
C3 University of London; University College London
RP Hamer, M (corresponding author), UCL, Dept Epidemiol & Publ Hlth, 1-19 Torrington Pl, London WC1E 6BT, England.
EM m.hamer@ucl.ac.uk
RI Steptoe, Andrew/Y-2440-2019; Hamer, Mark/C-1602-2008
OI Steptoe, Andrew/0000-0001-7808-4943; Hamer, Mark/0000-0002-8726-7992
FU British Heart Foundation; Medical Research Council, UK; MRC [G0902037]
   Funding Source: UKRI
FX This work was supported by Sources of Funding: the British Heart
   Foundation and the Medical Research Council, UK.
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NR 30
TC 119
Z9 139
U1 2
U2 19
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0021-972X
EI 1945-7197
J9 J CLIN ENDOCR METAB
JI J. Clin. Endocrinol. Metab.
PD JAN
PY 2012
VL 97
IS 1
BP E29
EP E34
DI 10.1210/jc.2011-2132
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 893YM
UT WOS:000300393800004
PM 22031509
OA Bronze
DA 2025-06-11
ER

PT J
AU Kornicka-Garbowska, K
   Bourebaba, L
   Röcken, M
   Marycz, K
AF Kornicka-Garbowska, Katarzyna
   Bourebaba, Lynda
   Roecken, Michael
   Marycz, Krzysztof
TI Sex Hormone Binding Globulin (SHBG) Mitigates ER Stress in Hepatocytes
   In Vitro and Ex Vivo
SO CELLS
LA English
DT Article
DE sex hormone binding globulin; SHBG; liver; metabolic syndrome;
   endoplasmic reticulum stress
AB Despite multiple research studies regarding metabolic syndrome and diabetes, the full picture of their molecular background and pathogenies remains elusive. The latest studies revealed that sex hormone-binding globulin (SHBG)-a serum protein released mainly by the liver-may participate in metabolic dysregulation, as its low serum level correlates with a risk for obesity, metabolic syndrome, and diabetes. Yet, the molecular phenomenon linking SHBG with these disorders remains unclear. In the presented study, we investigate how exogenous SHBG affects metabolically impaired hepatocytes with special attention to endoplasmic reticulum stress (ER stress) and lipid metabolism both in vitro and ex vivo. For that reason, palmitate-treated HepG2 cells and liver tissue samples collected post mortem were cultured in the presence of 50 nM and 100 nM SHBG. We found that SHBG protects against ER stress development and its progression. We have found that SHBG decreased the expression levels of inositol-requiring enzyme 1 (IRE1 alpha), activating transcription factor 6 (ATF6), DNA damage-inducible transcript 3 (CHOP), and immunoglobulin heavy chain-binding protein (BIP). Furthermore, we have shown that it regulates lipolytic gene expression ex vivo. Additionally, herein, we deliver a novel large-animal model to study SHBG in translational research. Our data provide new insights into the cellular and molecular mechanisms by which SHBG modulates hepatocyte metabolism and offer a new experimental approach to study SHBG in human diseases.
C1 [Kornicka-Garbowska, Katarzyna; Bourebaba, Lynda; Marycz, Krzysztof] Wroclaw Univ Environm & Life Sci, Fac Biol & Anim Sci, Dept Expt Biol, Norwida 27B St,A7 Bldg, PL-50375 Wroclaw, Poland.
   [Kornicka-Garbowska, Katarzyna; Marycz, Krzysztof] Int Inst Translat Med, Jesionowa 11, PL-55114 Malin, Wisznia Mala, Poland.
   [Roecken, Michael] Justus Liebig Univ, Fac Vet Med, Equine Clin Equine Surg, D-35392 Giessen, Germany.
C3 Wroclaw University of Environmental & Life Sciences; Justus Liebig
   University Giessen
RP Marycz, K (corresponding author), Wroclaw Univ Environm & Life Sci, Fac Biol & Anim Sci, Dept Expt Biol, Norwida 27B St,A7 Bldg, PL-50375 Wroclaw, Poland.; Marycz, K (corresponding author), Int Inst Translat Med, Jesionowa 11, PL-55114 Malin, Wisznia Mala, Poland.
EM kornicka.katarzyna@gmail.com; lynda.bourebaba@upwr.edu.pl;
   Michael.Roecken@vetmed.uni-giessen.de; krzysztof.marycz@upwr.edu.pl
RI Bourebaba, Lynda/AAX-7613-2020; Kornicka-Garbowska,
   Katarzyna/A-5313-2017
OI Kornicka-Garbowska, Katarzyna/0000-0002-2311-5789; Lynda,
   Bourebaba/0000-0003-0660-8706
FU National Science Centre in Poland [2018/29/B/NZ7/02662,
   2019/35/B/NZ7/03651]
FX The work was supported by a grant from National Science Centre in Poland
   during the realization of the projects: 'Inhibition of tyrosine
   phosphatase as a strategy to enhance insulin sensitivity through
   activation of chaperone mediated autophagy and amelioration of
   inflammation and cellular stress in the liver of equine metabolic
   syndrome (EMS) horses.' (2018/29/B/NZ7/02662) and "Exploring the role
   and therapeutic potential of sex hormone binding globulin (SHBG) in the
   course of insulin resistance, inflammation, lipotoxicity in adipose stem
   progenitor cells and adipocytes in equine metabolic syndrome (EMS)
   mares." (2019/35/B/NZ7/03651). The publication is financed under the
   Leading Research Groups support project from the subsidy increased for
   the period 2020-2025 in the amount of 2% of the subsidy referred to Art.
   387 (3) of the Law of 20 July 2018 on Higher Education and Science,
   obtained in 2019.
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NR 49
TC 14
Z9 14
U1 0
U2 3
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2073-4409
J9 CELLS-BASEL
JI Cells
PD APR
PY 2021
VL 10
IS 4
AR 755
DI 10.3390/cells10040755
PG 20
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA RR1TO
UT WOS:000642889300001
PM 33808055
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Yang, SJ
   Li, YP
   Liu, L
   Wan, ZC
   Xu, QT
   Xie, C
   Song, LL
   Wang, YJ
   Chen, H
   Mei, SR
AF Yang, Sijie
   Li, Yaping
   Liu, Ling
   Wan, Zhengce
   Xu, Qitong
   Xie, Chang
   Song, Lulu
   Wang, Youjie
   Chen, Hui
   Mei, Surong
TI Associations Between Organophosphate Esters Exposure and Metabolic
   Syndrome: Exploring the Mediating Role of Oxidative Stress and
   Inflammation in Adults
SO EXPOSURE AND HEALTH
LA English
DT Article
DE Organophosphate esters; Metabolic syndrome; Oxidative stress;
   Inflammation; Mediation
ID C-REACTIVE PROTEIN; FLAME RETARDANTS; URINARY METABOLITES; PLASTICIZERS;
   POPULATION; EXTRACTION; HEALTH
AB Epidemiological evidence regarding the relationships of organophosphate esters (OPEs) with metabolic syndrome (MetS) and its underlying mechanism was largely unknown. This study sought to estimate the associations of individual OPEs and their mixture with MetS risk, while also evaluating the potential mediation of oxidative stress and inflammation biomarkers. We measured urinary OPE metabolites, urinary biomarkers of oxidative stress, and serum biomarkers of inflammation among 694 adults based on a case-control design. Our findings revealed positive associations between urinary 1-hydroxy-2-propyl bis(1-chloro-2-propyl) phosphate (BCIPHIPP) and bis(2-butoxyethyl) phosphate (BBOEP) and elevated odds of MetS risk. Bayesian kernel machine regression (BKMR) and weighted quantile sum (WQS) analyses demonstrated the overall effect of the OPE mixtures on MetS risk, with BBOEP identified as the primary contributor. Mediation analysis further revealed that the association between urinary BCIPHIPP and BBOEP and MetS risk was mediated by urinary 8-hydroxy-2-deoxyguanosine (8-OHdG), with mediation proportions of 23.27% and 8.70%, respectively. In addition, serum C-reactive protein (CRP) concentration mediated the association between BBOEP and MetS risk, and the proportion of mediation was 16.32%. Our results indicated that oxidative stress and inflammation might exert a substantial influence on the associations between OPE exposure and the risk of MetS.
C1 [Yang, Sijie; Li, Yaping; Liu, Ling; Xu, Qitong; Xie, Chang; Mei, Surong] Huazhong Univ Sci & Technol, Tongji Med Coll,Minist Educ,Key Lab Environm & Hlt, Sch Publ Hlth,Minist Environm Protect, State Key Lab Environm Hlth Incubat,Key Lab Enviro, 13 Hangkong Rd, Wuhan 430030, Hubei, Peoples R China.
   [Wan, Zhengce] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Hlth Management Ctr, Wuhan, Peoples R China.
   [Song, Lulu; Wang, Youjie; Chen, Hui] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Dept Maternal & Child Hlth, Wuhan, Hubei, Peoples R China.
C3 Huazhong University of Science & Technology; Ministry of Education -
   China; Huazhong University of Science & Technology; Huazhong University
   of Science & Technology
RP Mei, SR (corresponding author), Huazhong Univ Sci & Technol, Tongji Med Coll,Minist Educ,Key Lab Environm & Hlt, Sch Publ Hlth,Minist Environm Protect, State Key Lab Environm Hlth Incubat,Key Lab Enviro, 13 Hangkong Rd, Wuhan 430030, Hubei, Peoples R China.; Chen, H (corresponding author), Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Dept Maternal & Child Hlth, Wuhan, Hubei, Peoples R China.
EM chenhui@hust.edu.cn; surongmei@hust.edu.cn
RI Xu, Qi-Tong/KFR-4883-2024; Song, Lulu/X-4115-2019; Yuxuan,
   Yang/NGS-7786-2025
OI xie, chang/0000-0001-5625-7321
FU National Natural Science Foundation of China [42077397]
FX This research was funded by the National Natural Science Foundation of
   China (No. 42077397).
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NR 48
TC 0
Z9 0
U1 16
U2 38
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 2451-9766
EI 2451-9685
J9 EXPOS HEALTH
JI Expo. Health
PD FEB
PY 2025
VL 17
IS 1
BP 177
EP 189
DI 10.1007/s12403-024-00653-5
EA JUL 2024
PG 13
WC Water Resources
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Water Resources
GA T5K7J
UT WOS:001263688100001
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Mularczyk, M
   Bourebaba, N
   Marycz, K
   Bourebaba, L
AF Mularczyk, Malwina
   Bourebaba, Nabila
   Marycz, Krzysztof
   Bourebaba, Lynda
TI Astaxanthin Carotenoid Modulates Oxidative Stress in Adipose-Derived
   Stromal Cells Isolated from Equine Metabolic Syndrome Affected Horses by
   Targeting Mitochondrial Biogenesis
SO BIOMOLECULES
LA English
DT Article
DE astaxanthin; antioxidant; equine metabolic syndrome; ASCs; mitochondria;
   OXPHOS
ID INSULIN-RESISTANCE; STEM-CELLS; TNF-ALPHA; IN-VITRO; TISSUE;
   PATHOGENESIS; ADIPOKINES; DISORDERS; PLASMA; DAMAGE
AB Astaxanthin is gaining recognition as a natural bioactive component. This study aimed to test whether astaxanthin could protect adipose-derived stromal stem cells (ASCs) from apoptosis, mitochondrial dysfunction and oxidative stress. Phaffia rhodozyma was used to extract astaxanthin, whose biocompatibility was tested after 24,48 and 72 h of incubation with the cells; no harmful impact was found. ASCs were treated with optimal concentrations of astaxanthin. Several parameters were examined: cell viability, apoptosis, reactive oxygen levels, mitochondrial dynamics and metabolism, superoxide dismutase activity, and astaxanthin's antioxidant capacity. A RT PCR analysis was performed after each test. The astaxanthin treatment significantly reduced apoptosis by modifying the normalized caspase activity of pro-apoptotic pathways (p21, p53, and Bax). Furthermore, by regulating the expression of related master factors SOD1, SOD2, PARKIN, PINK 1, and MFN 1, astaxanthin alleviated the oxidative stress and mitochondrial dynamics failure caused by EMS. Astaxanthin restored mitochondrial oxidative phosphorylation by stimulating markers associated with the OXPHOS machinery: COX4I1, COX4I2, UQCRC2, NDUFA9, and TFAM. Our results suggest that astaxanthin has the potential to open new possibilities for potential bio-drugs to control and suppress oxidative stress, thereby improving the overall metabolic status of equine ASCs suffering from metabolic syndrome.
C1 [Mularczyk, Malwina; Bourebaba, Nabila; Marycz, Krzysztof; Bourebaba, Lynda] Wroclaw Univ Environm & Life Sci, Fac Biol & Anim Sci, Dept Expt Biol, Norwida 27B, PL-50375 Wroclaw, Poland.
   [Mularczyk, Malwina; Marycz, Krzysztof] Int Inst Translat Med, Jesionowa 11, PL-55114 Malin, Wisznia Mala, Poland.
C3 Wroclaw University of Environmental & Life Sciences
RP Mularczyk, M; Bourebaba, L (corresponding author), Wroclaw Univ Environm & Life Sci, Fac Biol & Anim Sci, Dept Expt Biol, Norwida 27B, PL-50375 Wroclaw, Poland.; Mularczyk, M (corresponding author), Int Inst Translat Med, Jesionowa 11, PL-55114 Malin, Wisznia Mala, Poland.
EM malwina.mularczyk@upwr.edu.pl; nabila.bourebaba@upwr.edu.pl;
   k.marycz@mimt.com.pl; lynda.bourebaba@upwr.edu.pl
RI Bourebaba, Lynda/AAX-7613-2020; Marycz, Krzysztof/A-2249-2017;
   Bourebaba, Nabila/JRY-9553-2023
OI Lynda, Bourebaba/0000-0003-0660-8706; Mularczyk,
   Malwina/0000-0001-8189-9545
FU project "UPWR 2.0: international and interdisciplinary programme of
   development ofWroclaw University of Environmental and Life Sciences" -
   European Social Fund under the Operational Program Knowledge Education
   Development [POWR.03.05.00-00-Z062/18]
FX Publication financed by the project "UPWR 2.0: international and
   interdisciplinary programme of development ofWroclaw University of
   Environmental and Life Sciences", co-financed by the European Social
   Fund under the Operational Program Knowledge Education Development,
   under contract No. POWR.03.05.00-00-Z062/18 of 4 June 2019.
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NR 86
TC 11
Z9 12
U1 4
U2 24
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2218-273X
J9 BIOMOLECULES
JI Biomolecules
PD AUG
PY 2022
VL 12
IS 8
AR 1039
DI 10.3390/biom12081039
PG 23
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 4C1AI
UT WOS:000846195300001
PM 36008933
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Chávez-Gutiérrez, E
   Fuentes-Venado, CE
   Rodríguez-Páez, L
   Guerra-Araiza, C
   Larqué, C
   Martínez-Herrera, E
   Ocharan-Hernández, ME
   Lomelí, J
   Loza-Mejía, MA
   Salazar, JR
   Meneses-Ruiz, DM
   Gallardo, JM
   Pinto-Almazán, R
AF Chavez-Gutierrez, Edwin
   Erika Fuentes-Venado, Claudia
   Rodriguez-Paez, Lorena
   Guerra-Araiza, Christian
   Larque, Carlos
   Martinez-Herrera, Erick
   Esther Ocharan-Hernandez, Maria
   Lomeli, Joel
   Loza-Mejia, Marco A.
   Rodrigo Salazar, Juan
   Maria Meneses-Ruiz, Dulce
   Manuel Gallardo, Juan
   Pinto-Almazan, Rodolfo
TI High Fructose and High Fat Diet Impair Different Types of Memory through
   Oxidative Stress in a Sex- and Hormone-Dependent Manner
SO METABOLITES
LA English
DT Article
DE metabolic syndrome; ovariectomy; orchiectomy; memory; oxidative stress
ID METABOLIC SYNDROME; RECOGNITION MEMORY; GENDER DIFFERENCES; SPATIAL
   MEMORY; SPINE DENSITY; SHORT-TERM; LONG-TERM; COGNITION; LIVER; RATS
AB Metabolic syndrome (MetS) contributes to the spread of cardiovascular diseases, diabetes mellitus type 2, and neurodegenerative diseases. Evaluation of sex- and hormone-dependent changes in body weight, blood pressure, blood lipids, oxidative stress markers, and alterations in different types of memory in Sprague-Dawley rats fed with a high fat and high fructose (HFHF) diet were evaluated. After 12 weeks of feeding the male and female rats with HFHF, body weight gain, increase in blood pressure, and generation of dyslipidemia compared to the animals fed with chow diet were observed. Regarding memory, it was noted that gonadectomy reverted the effects of HFHF in the 24 h novel object recognition task and in spatial learning/memory analyzed through Morris water maze, males being more affected than females. Nevertheless, gonadectomy did not revert long-term memory impairment in the passive avoidance task induced by HFHF nor in male or female rats. On the other hand, sex-hormone-diet interaction was observed in the plasma concentration of malondialdehyde and nitric oxide. These results suggest that the changes observed in the memory and learning of MetS animals are sex- and hormone-dependent and correlate to an increase in oxidative stress.
C1 [Chavez-Gutierrez, Edwin] Inst Politecn Nacl, Escuela Nacl Ciencias Biol, Ciencias Biomed & Biotecnol Mol, Mexico City 11340, DF, Mexico.
   [Erika Fuentes-Venado, Claudia] Hosp Gen Zona 197, Serv Med Fis & Rehabil, Texcoco 56108, Mexico.
   [Rodriguez-Paez, Lorena] Inst Politecn Nacl, Dept Bioquim, Escuela Nacl Ciencias Biol, Prolongac Manuel Carpio & Plan Ayala S-N, Mexico City 11340, DF, Mexico.
   [Guerra-Araiza, Christian] Social Secur Mexican Inst IMSS, Natl Med Ctr XXI Century, Special Hosp Bernardo Sepulveda, Med Res Unit Pharmacol, Mexico City 06720, DF, Mexico.
   [Larque, Carlos] Univ Nacl Autonoma Mexico, Fac Med, Dept Embriol & Genet, Ave Univ 3000, Mexico City 04510, DF, Mexico.
   [Martinez-Herrera, Erick; Esther Ocharan-Hernandez, Maria; Lomeli, Joel] Inst Politecn Nacl, Escuela Super Med, Secc Estudios Posgrad & Invest, Mexico City 11340, DF, Mexico.
   [Martinez-Herrera, Erick] SERGAS UVIGO, Efficiency Qual & Costs Hlth Serv Res Grp EFISALU, Galicia Sur Hlth Res Inst IIS Galicia Sur, Vigo 36213, Spain.
   [Loza-Mejia, Marco A.; Rodrigo Salazar, Juan] Univ La Salle Mexico, Chem Sci Sch, Design Isolat & Synth Bioact Mol Res Grp, Benjamin Franklin 45, Mexico City 06140, DF, Mexico.
   [Maria Meneses-Ruiz, Dulce; Pinto-Almazan, Rodolfo] Univ La Salle Mexico, Noncommunicable Dis Res Grp, Benjamin Franklin 45, Mexico City 06140, DF, Mexico.
   [Manuel Gallardo, Juan] Inst Mexicano Seguro Social, Ctr Med Nacl Siglo XXI, Hosp Especialidades, Unidad Invest Med Enfermedades Nefrol, Mexico City 06720, DF, Mexico.
   [Manuel Gallardo, Juan] Univ Autonoma Metropolitana, Doctorado Ciencias Biol & Salud, Mexico City 14387, DF, Mexico.
C3 Instituto Politecnico Nacional - Mexico; Instituto Mexicano del Seguro
   Social; Instituto Politecnico Nacional - Mexico; Instituto Mexicano del
   Seguro Social; Universidad Nacional Autonoma de Mexico; Instituto
   Politecnico Nacional - Mexico; Instituto Mexicano del Seguro Social;
   Universidad Autonoma Metropolitana - Mexico
RP Guerra-Araiza, C (corresponding author), Social Secur Mexican Inst IMSS, Natl Med Ctr XXI Century, Special Hosp Bernardo Sepulveda, Med Res Unit Pharmacol, Mexico City 06720, DF, Mexico.; Pinto-Almazán, R (corresponding author), Univ La Salle Mexico, Noncommunicable Dis Res Grp, Benjamin Franklin 45, Mexico City 06140, DF, Mexico.
EM chz_edwin.bioexp@hotmail.com; cefvenado@hotmail.com;
   lorena_rpaez@yahoo.com.mx; christianguerra2001@gmail.com;
   skiuty@hotmail.com; erickmartinez_69@hotmail.com;
   estherocharan@hotmail.com; jlomeli_glez@yahoo.com.mx;
   marcoantonio.loza@lasalle.mx; juan.salazar@lasalle.mx;
   dulce.meneses@lasalle.mx; jmgallardom@gmail.com;
   rodolfopintoalmazan@gmail.com
RI Chávez Gutiérrez, Edwin/KCY-3394-2024; Salazar, Juan/AFQ-6683-2022;
   Martínez-Herrera, Erick/AEW-5266-2022; GALLARDO, Juan/HGF-1360-2022;
   Larqué, Carlos/B-3834-2011; Loza-Mejia, Marco A./F-3557-2019;
   Pinto-Almazan, Rodolfo/F-3483-2013
OI Chavez Gutierrez, Edwin/0000-0002-8571-4111; Larque Velazquez, Carlos
   Alfonso/0000-0003-0634-195X; GALLARDO, Juan Manuel/0000-0001-8833-4651;
   Rodriguez-Paez, Lorena/0000-0002-5706-8378; Loza-Mejia, Marco
   A./0000-0002-8449-0806; Martinez-Herrera, Erick/0000-0001-7298-158X;
   Pinto-Almazan, Rodolfo/0000-0002-5210-5395; Lomeli,
   Joel/0000-0001-5318-8949
FU CONACyT [CVU:818903]
FX This work was submitted in partial fulfillment of the requirements for
   the PhD degree of Edwin Chavez-Gutierrez at the Doctorado en Ciencias en
   Biomedicina y Biotecnologia Molecular, Escuela Nacional de Ciencias
   Biologicas (Instituto Politecnico Nacional, Mexico City 11340, Mexico).
   Edwin Chavez-Gutierrez received financial support from CONACyT
   (CVU:818903). The authors would like to thank Heberto Arboleya Casanova
   for his support throughout the study. This research received no external
   funding.
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NR 64
TC 6
Z9 6
U1 2
U2 10
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2218-1989
J9 METABOLITES
JI Metabolites
PD APR
PY 2022
VL 12
IS 4
AR 341
DI 10.3390/metabo12040341
PG 18
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 0T3CN
UT WOS:000786848100001
PM 35448528
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Lin, HL
   Lin, SH
   Shen, KP
   Chan, HC
   Tseng, YH
   Yen, HW
   Law, SH
   Ke, LY
AF Lin, Hui-Li
   Lin, Shih-Hsiung
   Shen, Kuo-Ping
   Chan, Hua-Chen
   Tseng, Yu-Hsiu
   Yen, Hsueh-Wei
   Law, Shi-Hui
   Ke, Liang-Yin
TI Efficiency comparison of PGBR extract and γ-oryzanol in antioxidative
   stress and anti-inflammatory properties against metabolic syndrome
SO JOURNAL OF FOOD BIOCHEMISTRY
LA English
DT Article
DE inflammation; metabolic syndrome; oxidative stress; pregerminated brown
   rice; gamma-oryzanol
ID HIGH-FAT DIET; GLUCOSE-METABOLISM; INSULIN-RESISTANCE; SKELETAL-MUSCLE;
   MOUSE MODEL; TNF-ALPHA; INFLAMMATION; OBESITY; ASSOCIATION; MECHANISMS
AB This research aims to delineate the anti-inflammatory effect of pregerminated brown rice extract (PE) and gamma-oryzanol on improving metabolic features of high-fat diet (HFD)-induced metabolic syndrome (MetS) mouse model. C57BL/6 mice were randomly divided into eight groups: regular diet (RD), HFD, HFD-combined treatment of 0.5, 5, or 10 mg kg(-1) day(-1) oral gavage gamma-oryzanol, and 30, 300, or 600 mg kg(-1) day(-1) PE for 18 weeks. HFD-fed mice showed overweight, hyperglycemia, hyperlipidemia signs of metabolic disorder, and elevation of inflammatory cytokines such as IL-6, TNF-alpha, IFN-gamma, NO, PGE2 in serum and MAPKs, transcription factor p65, iNOS, and MDA in the liver. In contrast, HFD-fed mice showed lower levels of adiponectin in serum and antiperoxidation enzymes GPx, SOD, and catalase in the liver. While HFD-fed mice cotreated with PE or gamma-oryzanol, HFD-induced metabolic disorders, ROS, and inflammation were improved. The anti-MetS, antioxidative stress and anti-inflammation properties of PE were more potent than gamma-oryzanol. Practical applications Our study showed that PE or gamma-oryzanol supplement could help control metabolic disorders, oxidative stress, chronic inflammation, and related complications.
C1 [Lin, Hui-Li; Ke, Liang-Yin] Kaohsiung Med Univ, Lipid Sci & Aging Res Ctr, Kaohsiung, Taiwan.
   [Lin, Shih-Hsiung; Shen, Kuo-Ping] Meiho Univ, Dept Nursing, Pingtung, Taiwan.
   [Lin, Shih-Hsiung] Antai Tian Sheng Mem Hosp, Dept Paediat, Antai Med Care Cooperat, Pingtung, Taiwan.
   [Chan, Hua-Chen; Ke, Liang-Yin] Kaohsiung Med Univ Hosp, Ctr Lipid Biosci, Kaohsiung, Taiwan.
   [Tseng, Yu-Hsiu] Natl Kaohsiung Univ Hospitality & Tourism, Grad Inst Food Culture & Innovat, Kaohsiung, Taiwan.
   [Yen, Hsueh-Wei] Kaohsiung Med Univ Hosp, Div Cardiol, Dept Internal Med, Kaohsiung, Taiwan.
   [Law, Shi-Hui; Ke, Liang-Yin] Kaohsiung Med Univ, Dept Med Lab Sci & Biotechnol, Coll Hlth Sci, Kaohsiung, Taiwan.
   [Ke, Liang-Yin] Kaohsiung Med Univ, Grad Inst Med, Coll Med, Kaohsiung, Taiwan.
   [Ke, Liang-Yin] Kaohsiung Med Univ, Drug Dev & Value Creat Res Ctr, Kaohsiung, Taiwan.
C3 Kaohsiung Medical University; Kaohsiung Medical University; Kaohsiung
   Medical University Hospital; National Kaohsiung University of
   Hospitality & Tourism; Kaohsiung Medical University; Kaohsiung Medical
   University Hospital; Kaohsiung Medical University; Kaohsiung Medical
   University; Kaohsiung Medical University
RP Ke, LY (corresponding author), Kaohsiung Med Univ, Dept Med Lab Sci & Biotechnol, Coll Hlth Sci, Kaohsiung, Taiwan.
EM kly@kmu.edu.tw
RI Chen, Cheng-Ying/E-1662-2011; Ke, Liang-Yin/A-2778-2009
OI Ke, Liang-Yin/0000-0002-2547-0987
FU Taiwan Ministry of Science and Technology [108-2320-B-276-002-MY3,
   105-2320-B-276-003-MY2, 107-2314-B-037-114-MY3, 108-2811-B-037-500-];
   Kaohsiung Medical University [KMU-TC108A03-0]
FX This work was supported in part by grants from the Taiwan Ministry of
   Science and Technology (108-2320-B-276-002-MY3 to K-P.S.;
   105-2320-B-276-003-MY2, 108-2811-B-037-500-to H-L.L.;
   107-2314-B-037-114-MY3 to L-Y.K.), and from the Kaohsiung Medical
   University grant (KMU-TC108A03-0). The authors thank Prof. Shyh-Yu Shaw
   and Miss Tsui-Jung Lin for technical advice and support, and the help
   from the Division of Medical Statistics and Bioinformatics, Department
   of Medical Research, Kaohsiung Medical University Hospital.
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NR 51
TC 12
Z9 12
U1 0
U2 18
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0145-8884
EI 1745-4514
J9 J FOOD BIOCHEM
JI J. Food Biochem.
PD FEB
PY 2020
VL 44
IS 2
AR e13129
DI 10.1111/jfbc.13129
EA DEC 2019
PG 11
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA KM7AZ
UT WOS:000502896200001
PM 31846084
OA gold
DA 2025-06-11
ER

PT J
AU Hoveling, LA
   Liefbroer, AC
   Bültmann, U
   Smidt, N
AF Hoveling, Liza A.
   Liefbroer, Aart C.
   Bultmann, Ute
   Smidt, Nynke
TI Socioeconomic differences in metabolic syndrome development: examining
   the mediating role of chronic stress using the Lifelines Cohort Study
SO BMC PUBLIC HEALTH
LA English
DT Article
DE Metabolic syndrome; Socioeconomic factors; Long-term difficulties
   inventory; Longitudinal studies; Mediation
ID POSITION; INDICATORS; HEALTH
AB Background Metabolic syndrome (MetS) development strongly varies based on individuals' socioeconomic position (SEP), but to date, no studies have assessed the mediating role of perceived stress from long-term difficulties (chronic stress) in this association. The aim of this study is to examine the mediating role of chronic stress in the associations of the SEP measures education, occupational prestige and income, with MetS development, and whether associations between chronic stress and MetS are moderated by sex. Methods We used an adult subsample (n = 53,216) from the Lifelines Cohort Study without MetS at baseline. MetS development was measured 3.9 years after baseline (follow-up), and defined according to National Cholesterol Education Program's Adult Treatment Panel III (NCEP-ATPIII) criteria. Direct associations between SEP, chronic stress and MetS development were estimated using multivariable logistic and linear regression analyses, and were adjusted for age, sex, the other SEP measures, and time between baseline and follow-up. The mediating percentages of chronic stress explaining the associations between SEP and MetS development were estimated using the Karlson-Holm-Breen method. Results Upon follow-up, 7.4% of the participants had developed MetS. Years of education and occupational prestige were inversely associated with MetS development. Chronic stress suppressed the association between education and MetS development (5.6%), as well as the association between occupational prestige and MetS development (6.2%). No effect modification of sex on the chronic stress-MetS pathway was observed. Conclusions Chronic stress does not explain educational and occupational differences in developing MetS. In fact, individuals with more years of education or higher occupational prestige perceive more chronic stress than their lower SEP counterparts. Further, no difference between males and females was observed regarding the relationship between chronic stress and MetS development.
C1 [Hoveling, Liza A.; Liefbroer, Aart C.; Smidt, Nynke] Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, POB 30-001, NL-9700 RB Groningen, Netherlands.
   [Liefbroer, Aart C.] Netherlands Interdisciplinary Demog Inst, POB 11650, NL-2502 AR The Hague, Netherlands.
   [Liefbroer, Aart C.] Vrije Univ Amsterdam, Dept Sociol, De Boelelaan 1105, NL-1081 HV Amsterdam, Netherlands.
   [Bultmann, Ute] Univ Groningen, Univ Med Ctr Groningen, Dept Hlth Sci Community & Occupat Med, POB 30-001, NL-9700 RB Groningen, Netherlands.
C3 University of Groningen; Royal Netherlands Academy of Arts & Sciences;
   Netherlands Interdisciplinary Demographic Institute (NIDI-KNAW); Vrije
   Universiteit Amsterdam; University of Groningen
RP Hoveling, LA (corresponding author), Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, POB 30-001, NL-9700 RB Groningen, Netherlands.
EM l.a.hoveling@umcg.nl
RI Bültmann, Ute/J-4463-2014
OI Liefbroer, Aart/0000-0002-7884-3150; Smidt, Nynke/0000-0002-2778-8841;
   Hoveling, Liza/0000-0003-1093-1119; Bultmann, Ute/0000-0001-9589-9220
FU Netherlands Organization for Health Research and Development (ZonMw)
   [531003011]
FX This work was supported by The Netherlands Organization for Health
   Research and Development (ZonMw) [grant number 531003011]. ZonMw had no
   role in the design of the study; in the collection, analyses, or
   interpretation of data; in the writing of the manuscript; or in the
   decision to publish the results.
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U1 0
U2 6
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2458
J9 BMC PUBLIC HEALTH
JI BMC Public Health
PD FEB 8
PY 2022
VL 22
IS 1
AR 261
DI 10.1186/s12889-022-12684-1
PG 11
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA YV7WL
UT WOS:000752936900003
PM 35135520
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Hayashi, F
   Ohira, T
   Sato, S
   Nakano, H
   Okazaki, K
   Nagao, M
   Shimabukuro, M
   Sakai, A
   Kazama, JJ
   Hosoya, M
   Takahashi, A
   Maeda, M
   Yabe, H
   Yasumura, S
   Ohto, H
   Kamiya, K
AF Hayashi, Fumikazu
   Ohira, Tetsuya
   Sato, Shiho
   Nakano, Hironori
   Okazaki, Kanako
   Nagao, Masanori
   Shimabukuro, Michio
   Sakai, Akira
   Kazama, Junichiro James
   Hosoya, Mitsuaki
   Takahashi, Atsushi
   Maeda, Masaharu
   Yabe, Hirooki
   Yasumura, Seiji
   Ohto, Hitoshi
   Kamiya, Kenji
TI Association between Dietary Diversity and Sociopsychological Factors and
   the Onset of Dyslipidemia after the Great East Japan Earthquake:
   Fukushima Health Management Survey
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Article
DE dyslipidemia; sociopsychological factor; dietary diversity score;
   disaster victims; Fukushima nuclear accident; Great East Japan
   Earthquake
ID POWER-PLANT ACCIDENT; POSTTRAUMATIC STRESS; MYOCARDIAL-INFARCTION;
   METABOLIC SYNDROME; MENTAL-HEALTH; RISK-FACTORS; DISASTER; EVACUATION;
   RESIDENTS; SYMPTOMS
AB This study aimed to clarify the relationship between the onset of low-density lipoprotein hypercholesterolemia (hyper-LDLemia), high-density lipoprotein hypocholesterolemia (hypo-HDLemia), and hyper-triglyceridemia (hyper-TGemia) and lifestyle/socio-psychological factors among Fukushima evacuation area residents after the Great East Japan Earthquake. Participants included 11,274 non-hyper-LDLemia, 16,581 non-hypo-HDLemia, and 12,653 non-hyper-TGemia cases in the Fiscal Year (FY) 2011. In FY2011, these participants underwent a health checkup and responded to a mental health and lifestyle survey. The onset of each disease was followed through FY2017. The evacuation experience was positively associated with the risk of hyper-LDLemia, hypo-HDLemia, or hyper-TGemia. Conversely, the middle high dietary diversity score was negatively associated with the onset of hyper-TGemia. Moreover, low sleep satisfaction was positively associated with hypo-HDLemia and hyper-TGemia. The "almost never" exercise habit was positively associated with hypo-HDLemia. Current smoking and audible nuclear power plant explosions were positively associated with the risk of hyper-TGemia. Drinking habits exhibited a negative association with the onset of hyper-LDLemia, hypo-HDLemia, and hyper-TGemia. The results of this study indicate the need for continuous improvement in lifestyle, as well as efforts to eliminate the impact of disasters to prevent the onset of dyslipidemia among disaster evacuees.
C1 [Hayashi, Fumikazu; Ohira, Tetsuya; Sato, Shiho; Nakano, Hironori; Okazaki, Kanako; Nagao, Masanori; Shimabukuro, Michio; Sakai, Akira; Kazama, Junichiro James; Hosoya, Mitsuaki; Takahashi, Atsushi; Maeda, Masaharu; Yabe, Hirooki; Yasumura, Seiji; Ohto, Hitoshi; Kamiya, Kenji] Fukushima Med Univ, Radiat Med Sci Ctr Fukushima Hlth Management Surv, 1 Hikariga Oka, Fukushima 9601295, Japan.
   [Hayashi, Fumikazu; Ohira, Tetsuya; Sato, Shiho; Nakano, Hironori; Okazaki, Kanako; Nagao, Masanori] Fukushima Med Univ, Dept Epidemiol, Sch Med, 1 Hikariga Oka, Fukushima 9601295, Japan.
   [Okazaki, Kanako] Fukushima Med Univ, Dept Phys Therapy, Sch Med, 1 Hikariga Oka, Fukushima 9601295, Japan.
   [Shimabukuro, Michio] Fukushima Med Univ, Dept Diabet Endocrinol & Metab, Sch Med, 1 Hikariga Oka, Fukushima 9601295, Japan.
   [Sakai, Akira] Fukushima Med Univ, Dept Radiat Life Sci, Sch Med, 1 Hikariga Oka, Fukushima 9601295, Japan.
   [Kazama, Junichiro James] Fukushima Med Univ, Dept Nephrol & Hypertens, Sch Med, 1 Hikariga Oka, Fukushima 9601295, Japan.
   [Hosoya, Mitsuaki] Fukushima Med Univ, Dept Pediat, Sch Med, 1 Hikariga Oka, Fukushima 9601295, Japan.
   [Takahashi, Atsushi] Fukushima Med Univ, Dept Gastroenterol, Sch Med, 1 Hikariga Oka, Fukushima 9601295, Japan.
   [Maeda, Masaharu] Fukushima Med Univ, Dept Disaster Psychiat, Sch Med, 1 Hikariga Oka, Fukushima 9601295, Japan.
   [Yabe, Hirooki] Fukushima Med Univ, Dept Neuropsychiat, Sch Med, 1 Hikariga Oka, Fukushima 9601295, Japan.
   [Yasumura, Seiji] Fukushima Med Univ, Dept Publ Hlth, Sch Med, 1 Hikariga Oka, Fukushima 9601295, Japan.
   [Kamiya, Kenji] Hiroshima Univ, Res Inst Radiat Biol & Med, Minami Ku, 1-2-3 Kasumi, Hiroshima 7348553, Japan.
C3 Fukushima Medical University; Fukushima Medical University; Fukushima
   Medical University; Fukushima Medical University; Fukushima Medical
   University; Fukushima Medical University; Fukushima Medical University;
   Fukushima Medical University; Fukushima Medical University; Fukushima
   Medical University; Fukushima Medical University; Hiroshima University
RP Hayashi, F (corresponding author), Fukushima Med Univ, Radiat Med Sci Ctr Fukushima Hlth Management Surv, 1 Hikariga Oka, Fukushima 9601295, Japan.; Hayashi, F (corresponding author), Fukushima Med Univ, Dept Epidemiol, Sch Med, 1 Hikariga Oka, Fukushima 9601295, Japan.
EM fhayashi@fmu.ac.jp
RI SATO, SHIHO/MEE-4755-2025
OI Shimabukuro, Michio/0000-0001-7835-7665; Nagao,
   Masanori/0000-0001-9382-8023; NAKANO, Hironori/0000-0002-3783-2914;
   Hosoya, Mitsuaki/0000-0003-1626-3625; hayashi,
   fumikazu/0000-0002-6888-6640; Ohto, Hitoshi/0000-0003-0340-883X;
   Yasumura, Seiji/0000-0002-4715-2840; Sakai, Akira/0000-0003-0128-8395;
   Ohira, Tetsuya/0000-0003-4532-7165; Takahashi,
   Atsushi/0000-0003-0568-8361
FU national "Health Fund for Children and Adults Affected by the Nuclear
   Incident"; JSPS KAKENHI [JP20K19712]
FX This survey was conducted as part of "Fukushima Prefecture's
   postdisaster recovery plans" and was supported by the national "Health
   Fund for Children and Adults Affected by the Nuclear Incident". The
   funding organization had no role in the design of the study, data
   collection, analysis, interpretation of data, or writing of the
   manuscript. This work was supported by JSPS KAKENHI Grant Number
   JP20K19712.
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NR 56
TC 2
Z9 2
U1 0
U2 1
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD NOV
PY 2022
VL 19
IS 22
AR 14636
DI 10.3390/ijerph192214636
PG 20
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA 6K0DK
UT WOS:000887184200001
PM 36429357
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Cruz, EMS
   de Morais, JMB
   da Rosa, CVD
   Simoes, MD
   Comar, JF
   Chuffa, LGD
   Seiva, FRF
AF Souza Cruz, Ellen Mayara
   Bitencourt de Morais, Juliana Maria
   Dalto da Rosa, Carlos Vinicius
   Simoes, Mellina da Silva
   Comar, Jurandir Fernando
   de Almeida Chuffa, Luiz Gustavo
   Ferreira Seiva, Fabio Rodrigues
TI Long-term sucrose solution consumption causes metabolic alterations and
   affects hepatic oxidative stress in Wistar rats
SO BIOLOGY OPEN
LA English
DT Article
DE Sucrose solution; Metabolic syndrome; Hepatic tissue; Oxidative stress
ID NONALCOHOLIC FATTY LIVER; INSULIN-RESISTANCE; DRINKING-WATER;
   FOOD-INTAKE; GLUCOSE; FRUCTOSE; DIET; OBESITY; CARBOHYDRATE; DISEASE
AB As the number of overweight and obese people has risen in recent years, there has been a parallel increase in the number of people with metabolic syndrome, diabetes and non-alcoholic fatty liver disease. The consumption of artificially sweetened beverages contributes to these epidemics. This study investigated the long-term effects of ingestion of a 40% sucrose solution on serum and hepatic parameters in male Wistar rats (Rattus norvegicus). After 180 days, the glycemic response, lipid profile and hepatic oxidative stress were compared to those of rats maintained on water. Sucrose ingestion led to higher body weight, increased fat deposits, reduced voluntary food intake and reduced feeding efficiency. Rats that received sucrose solution showed early signs of glucose intolerance and insulin resistance, such as hyperinsulinemia. Serum triacylglycerol (TG), very-low density lipoprotein (VLDL), cholesterol, ALT and AST levels increased after sucrose consumption. Elevated malondialdehyde and superoxide dismutase (SOD) levels and reduced glutathione levels characterize the hepatic oxidative stress due to sucrose ingestion. Liver sample histology showed vacuolar traces and increased fibrotic tissue. Our data showed the harmful effects of chronic consumption of sucrose solution, which can cause alterations that are found frequently in obesity, glucose intolerance and non-alcoholic hepatic disease, characteristics of metabolic syndrome.
C1 [Souza Cruz, Ellen Mayara; Bitencourt de Morais, Juliana Maria; Dalto da Rosa, Carlos Vinicius; Ferreira Seiva, Fabio Rodrigues] UENP, Biol Sci Ctr, Dept Biol, Luiz Meneghel Campus, BR-8630000 Bandeirantes, Parana, Brazil.
   [Simoes, Mellina da Silva; Comar, Jurandir Fernando] Univ Estadual Maringa, Dept Biochem, BR-87020900 Maringa, Parana, Brazil.
   [de Almeida Chuffa, Luiz Gustavo] Univ Estadual Paulista, Inst Biosci Botucatu, Dept Anat, UNESP, BR-18618689 Botucatu, SP, Brazil.
   [Ferreira Seiva, Fabio Rodrigues] Univ Estadual Londrina, Dept Pathol, Post Grad Program Expt Pathol, BR-86057970 Londrina, Parana, Brazil.
C3 Universidade Estadual do Norte do Parana (UENP); Universidade Estadual
   de Maringa; Universidade Estadual Paulista; Universidade Estadual de
   Londrina
RP Seiva, FRF (corresponding author), UENP, Biol Sci Ctr, Dept Biol, Luiz Meneghel Campus, BR-8630000 Bandeirantes, Parana, Brazil.; Seiva, FRF (corresponding author), Univ Estadual Londrina, Dept Pathol, Post Grad Program Expt Pathol, BR-86057970 Londrina, Parana, Brazil.
EM fabio.seiva@uenp.edu.br
RI Chuffa, Luiz Gustavo/A-4085-2010; Bitencourt de Morais, Juliana
   Maria/AGH-5157-2022; Comar, Jurandir/I-7285-2013; Seiva,
   Fabio/I-5452-2013
OI Seiva, Fabio/0000-0002-7461-8773; Bitencourt de Morais, Juliana
   Maria/0000-0002-8406-3791; Rosa, Carlos Vinicius Dalto
   da/0000-0001-9428-630X; SOUZA CRUZ, ELLEN MAYARA/0000-0003-2445-5598;
   Comar, Jurandir Fernando/0000-0002-9518-7589
FU Brazilian agency Conselho Nacional de Desenvolvimento Cientifico e
   Tecnologico; Brazilian agency Fundacao Araucaria [05/2018 -
   CIC/PROPG/UENP]
FX This study was supported by the Brazilian agencies Conselho Nacional de
   Desenvolvimento Cientifico e Tecnologico and Fundacao Araucaria (number:
   05/2018 - CIC/PROPG/UENP) in the form of undergraduate scholarship.
   Universidade Estadual do Norte do Parana - UENP/PROPG/EDITORA UENP
   contributed paying the publication charge.
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   Zhang LQ, 2016, BIOL OPEN, V5, P1545, DOI 10.1242/bio.020875
NR 72
TC 23
Z9 25
U1 0
U2 7
PU COMPANY BIOLOGISTS LTD
PI CAMBRIDGE
PA BIDDER BUILDING, STATION RD, HISTON, CAMBRIDGE CB24 9LF, ENGLAND
SN 2046-6390
J9 BIOL OPEN
JI Biol. Open
PD MAR
PY 2020
VL 9
IS 3
AR bio047282
DI 10.1242/bio.047282
PG 8
WC Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics
GA KZ9JP
UT WOS:000523575800009
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Lu, XX
   Dallal, CM
   He, X
   Juon, HS
   Wang, MQ
   Lee, S
AF Lu, Xiaoxiao
   Dallal, Cher M.
   He, Xin
   Juon, Hee-Soon
   Wang, Ming Qi
   Lee, Sunmin
TI Parental caregiving trajectories and Metabolic Syndrome: A longitudinal
   study among Chinese women
SO SOCIAL SCIENCE & MEDICINE
LA English
DT Article
DE Caregiving; Stress; Metabolic syndrome; Chinese; Women
ID NUTRITION SURVEY; HEALTH; PREVALENCE; STRESS; IMPACT; RISK
AB Caregiving stress may play a role in the pathogenesis of Metabolic Syndrome (MetS). However, few studies have investigated the consequences of caregiving on this objectively measured health outcome. This study used population based longitudinal data to examine the causal relationship between caregiving trajectory and MetS among Chinese women. This is a retrospective analysis of 741 women using three waves of data from the Ever-Married Women Survey component of the China Health and Nutrition Survey (2004, 2006, and 2009). Group-based trajectory analysis was used to examine the caregiving trajectories among women in China. Three caregiving trajectories were identified. In multivariate analyses adjusting for potential covariates, 'rising to high-intense' caregivers (Odds Ratio (OR) = 3.78; 95% Confidence Interval (CI): 1.10, 12.93) and 'stable low-intense' caregivers (OR = 2.07; 95% CI: 1.09, 3.92) were associated with higher risk of MetS compared with non-caregivers. Moreover, caregivers who provided 'stable low-intense' parental care were found to be associated with hypertension, high glucose and high triglycerides than those awho did not provide caregiving for their parents. Our results demonstrate that the caregiving trajectories were significantly associated with the risk of MetS. Findings from the study can be used to develop future stress management interventions to decrease MetS risk among women who provide care to their parents.
C1 [Lu, Xiaoxiao; Dallal, Cher M.; He, Xin; Lee, Sunmin] Univ Maryland, Dept Epidemiol & Biostat, Sch Publ Hlth, 2242 Valley Dr, College Pk, MD 20742 USA.
   [Juon, Hee-Soon] Thomas Jefferson Univ, Dept Med Oncol, Philadelphia, PA 19107 USA.
   [Wang, Ming Qi] Univ Maryland, Dept Behav & Community Hlth, Sch Publ Hlth, College Pk, MD 20742 USA.
C3 University System of Maryland; University of Maryland College Park;
   Thomas Jefferson University; University System of Maryland; University
   of Maryland College Park
RP Lu, XX (corresponding author), Univ Maryland, Dept Epidemiol & Biostat, Sch Publ Hlth, 2242 Valley Dr, College Pk, MD 20742 USA.
EM xxluumd@gmail.com
RI Lu, Xiaoxiao/J-1014-2019; He, Xin/JYQ-1624-2024; Lee, Sunmin/C-9262-2011
OI Lee, Sunmin/0000-0001-9652-9475; He, Xin/0000-0002-9814-1666
FU National Institute of Nutrition and Food Safety; China Center for
   Disease Control and Prevention; Carolina Population Center; University
   of North Carolina at Chapel Hill; NIH [R01-HD30880, DK056350,
   R01-HD38700]; Fogarty International Center, NIH; China-Japan Friendship
   Hospital, Ministry of Health
FX This research uses data from China Health and Nutrition Survey (CHNS).
   We thank the National Institute of Nutrition and Food Safety, China
   Center for Disease Control and Prevention, Carolina Population Center,
   the University of North Carolina at Chapel Hill, the NIH (R01-HD30880,
   DK056350, and R01-HD38700) and the Fogarty International Center, NIH for
   financial support for the CHNS data collection and analysis files from
   1989 to 2006 and both parties plus the China-Japan Friendship Hospital,
   Ministry of Health for support for CHNS 2009 and future surveys.
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NR 38
TC 2
Z9 2
U1 0
U2 16
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0277-9536
EI 1873-5347
J9 SOC SCI MED
JI Soc. Sci. Med.
PD NOV
PY 2019
VL 240
AR 112559
DI 10.1016/j.socscimed.2019.112559
PG 9
WC Public, Environmental & Occupational Health; Social Sciences, Biomedical
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; Biomedical Social Sciences
GA JL4FG
UT WOS:000495485800006
PM 31557555
DA 2025-06-11
ER

PT J
AU Sánchez-Ortí, JV
   Balanzá-Martínez, V
   Correa-Ghisays, P
   Selva-Vera, G
   Vila-Francés, J
   Magdalena-Benedito, R
   San-Martin, C
   Victor, VM
   Escribano-Lopez, I
   Hernández-Mijares, A
   Vivas-Lalinde, J
   Crespo-Facorro, B
   Tabarés-Seisdedos, R
AF Sanchez-Orti, Joan Vicent
   Balanza-Martinez, Vicent
   Correa-Ghisays, Patricia
   Selva-Vera, Gabriel
   Vila-Frances, Joan
   Magdalena-Benedito, Rafael
   San-Martin, Constanza
   Victor, Victor M.
   Escribano-Lopez, Irene
   Hernandez-Mijares, Antonio
   Vivas-Lalinde, Juliana
   Crespo-Facorro, Benedicto
   Tabares-Seisdedos, Rafael
TI Specific metabolic syndrome components predict cognition and social
   functioning in people with type 2 diabetes mellitus and severe mental
   disorders
SO ACTA PSYCHIATRICA SCANDINAVICA
LA English
DT Article
DE cognition; metabolic syndrome; severe mental disorder; social
   functioning; type 2 diabetes mellitus
ID BIPOLAR DISORDER; SPANISH VERSION; SCHIZOPHRENIA; SCALE; INTERVENTIONS;
   PREVALENCE; EXERCISE; RISK
AB Objective Obesity and metabolic diseases such as metabolic syndrome (MetS) are more prevalent in people with type 2 diabetes mellitus (T2DM), major depressive disorder (MDD), bipolar disorder (BD), and schizophrenia (SZ). MetS components might be associated with neurocognitive and functional impairments in these individuals. The predictive and discriminatory validity of MetS and its components regarding those outcomes were assessed from prospective and transdiagnostic perspectives. Methods Metabolic syndrome components and neurocognitive and social functioning were assessed in 165 subjects, including 30 with SZ, 42 with BD, 35 with MDD, 30 with T2DM, and 28 healthy controls (HCs). A posteriori, individuals were classified into two groups. The MetS group consisted of those who met at least three of the following criteria: abdominal obesity (AO), elevated triglycerides (TG), reduced high-density lipoprotein cholesterol (HDL), elevated blood pressure (BP), and elevated fasting glucose (FPG); the remaining participants comprised the No-MetS group. Mixed one-way analysis of covariance and linear and binary logistic regression analyses were performed. Results Cognitive impairment was significantly greater in the MetS group (n = 82) than in the No-MetS group (n = 83), with small effect sizes (p < 0.05; eta(2)p = 0.02 - 0.03). In both groups, the most robust associations between MetS components and neurocognitive and social functioning were observed with TG and FPG (p < 0.05). There was also evidence for a significant relationship between cognition and BP in the MetS group (p < 0.05). The combination of TG, FPG, elevated systolic BP and HDL best classified individuals with greater cognitive impairment (p < 0.001), and TG was the most accurate (p < 0.0001). Conclusions Specific MetS components are significantly associated with cognitive impairment across somatic and psychiatric disorders. Our findings provide further evidence on the summative effect of MetS components to predict cognition and social functioning and allow the identification of individuals with worse outcomes. Transdiagnostic, lifestyle-based therapeutic interventions targeted at that group hold the potential to improve health outcomes.
C1 [Sanchez-Orti, Joan Vicent; Balanza-Martinez, Vicent; Correa-Ghisays, Patricia; Selva-Vera, Gabriel; Tabares-Seisdedos, Rafael] INCLIVA Biomed Res Inst, Valencia, Spain.
   [Sanchez-Orti, Joan Vicent; Balanza-Martinez, Vicent; Correa-Ghisays, Patricia; Selva-Vera, Gabriel; San-Martin, Constanza; Crespo-Facorro, Benedicto; Tabares-Seisdedos, Rafael] Univ Valencia, TMAP Evaluat Unit Personal Auton Dependency & Ser, Valencia, Spain.
   [Sanchez-Orti, Joan Vicent] Univ Valencia, Fac Psychol, Valencia, Spain.
   [Balanza-Martinez, Vicent; Correa-Ghisays, Patricia; Selva-Vera, Gabriel; Tabares-Seisdedos, Rafael] Hlth Inst Carlos III, Ctr Biomed Res Mental Hlth Network CIBERSAM, Madrid, Spain.
   [Balanza-Martinez, Vicent; Correa-Ghisays, Patricia; Selva-Vera, Gabriel; Tabares-Seisdedos, Rafael] Univ Valencia, Dept Med, Teaching Unit Psychiat & Psychol Med, Blasco Ibanez 17, Valencia 46010, Spain.
   [Balanza-Martinez, Vicent] Mental Hlth Unit Catarroja, Valencia, Spain.
   [Vila-Frances, Joan; Magdalena-Benedito, Rafael] Univ Valencia, IDAL Intelligent Data Anal Lab, Valencia, Spain.
   [San-Martin, Constanza] Univ Valencia, Dept Physiotherapy, Valencia, Spain.
   [Victor, Victor M.; Escribano-Lopez, Irene; Hernandez-Mijares, Antonio] Univ Hosp Dr Peset, Serv Endocrinol & Nutr, Valencia, Spain.
   [Victor, Victor M.] Fdn Promot Hlth & Biomed Res Valencian Reg FISABI, Valencia, Spain.
   [Victor, Victor M.] Univ Valencia, Dept Physiol, Valencia, Spain.
   [Vivas-Lalinde, Juliana] Mental Hlth Serv, Dept Psychiat, Valencia, Spain.
   [Crespo-Facorro, Benedicto] Univ Seville, Dept Psychiat, Fac Med, HU Virgen del Rocio IBIS, Seville, Spain.
C3 University of Valencia; University of Valencia; CIBER - Centro de
   Investigacion Biomedica en Red; CIBERSAM; University of Valencia;
   University of Valencia; University of Valencia; University of Valencia;
   University of Sevilla
RP Balanzá-Martínez, V (corresponding author), Univ Valencia, Dept Med, Teaching Unit Psychiat & Psychol Med, Blasco Ibanez 17, Valencia 46010, Spain.
EM joan_vicent@hotmail.com; vicente.balanza@uv.es; patricia.correa@uv.es;
   gabriel.selva@uv.es; joan.vila@uv.es; rafael.magdalena@uv.es;
   constanza.martin@uv.es; victor.victor@uv.es; suirlopez@hotmail.com;
   hernandez_antmij@gva.es; julianavivaslalinde@gmail.com;
   benedicto.crespo@unican.es; rafael.tabares@uv.es
RI VICTOR, VICTOR/I-3270-2015; Vila-Francés, Joan/AAF-7929-2019; San
   Martín, Constanza/AAY-2100-2020; Magdalena, Rafael/I-7969-2012;
   Tabares-Seisdedos, Rafael/H-6432-2013; Crespo-Facorro,
   BENEDICTO/AAY-2238-2021; Balanzá-Martínez, Vicent/C-3073-2011; Ortí,
   Joan/ABE-1616-2020; Hernandez Mijares, Antonio/D-3411-2011; Correa
   Ghisays, Patricia/J-7390-2018
OI Hernandez Mijares, Antonio/0000-0003-4099-1905; Sanchez Orti, Joan
   Vicent/0000-0002-8209-6688; Magdalena, Rafael/0000-0003-3752-8231;
   Correa Ghisays, Patricia/0000-0002-1752-7349; San Martin,
   Constanza/0000-0003-0347-5442; Balanza-Martinez,
   Vicent/0000-0001-7772-7396; Crespo-Facorro,
   Benedicto/0000-0003-0033-7132; Vila Frances, Joan/0000-0001-8293-8235
FU Carlos III Health Institute (ISCIII) [PI19/0838]; European Regional
   Development Fund (ERDF "A way to build Europe''); Ministry of Education
   of the Valencian Regional Government [PROMETEO/2019/027]; FISABIO
   (FISABIO; Valencia, Spain) [UGP-14-184]
FX This study was financed by Carlos III Health Institute (ISCIII) grants
   (PI19/0838), the European Regional Development Fund (ERDF ``A way to
   build Europe''), Ministry of Education of the Valencian Regional
   Government (PROMETEO/2019/027) and FISABIO (UGP--14--184 Project, funded
   by FISABIO; Valencia, Spain).
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NR 64
TC 12
Z9 12
U1 0
U2 14
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0001-690X
EI 1600-0447
J9 ACTA PSYCHIAT SCAND
JI Acta Psychiatr. Scand.
PD SEP
PY 2022
VL 146
IS 3
BP 215
EP 226
DI 10.1111/acps.13433
EA APR 2022
PG 12
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 3R3GA
UT WOS:000782048100001
PM 35359023
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Raatikainen, I
   Vanhala, M
   Mäntyselkä, P
   Heinonen, A
   Kautiainen, H
   Koponen, H
   Korniloff, K
AF Raatikainen, I
   Vanhala, M.
   Mantyselka, P.
   Heinonen, A.
   Kautiainen, H.
   Koponen, H.
   Korniloff, K.
TI Relationship between physical activity and predicted home presenteeism
   among participants with depressive symptoms with and without clinical
   depression. Findings from Finnish Depression and Metabolic Syndrome in
   Adults (FDMSA) study
SO EUROPEAN JOURNAL OF PSYCHIATRY
LA English
DT Article
DE Home presenteeism; Physical activity; Depression; Depressive symptoms
ID HEALTH-CARE; WORKPLACE; PRODUCTIVITY; ASSOCIATION; ABSENTEEISM;
   EXERCISE; ANXIETY; PEOPLE; SAMPLE; COSTS
AB Background and objectives: Depression can pose a major threat to an individual's ability to cope with daily activities. The aim of this study was to explore the relationship between physical activity (PA) and predicted home presenteeism (PHP) among depressive participants. The relationship between PHP and the severity of depressive symptoms was also investigated.
   Methods: A total of 760 participants with depressive symptoms (DS) aged >= 35 years participated in this study. The study was conducted between 2008 and 2016 in municipalities within the Central Finland Hospital District. DS were determined with the 21-item Beck Depression Inventory (BDI-21) with a cutoff score >= 10, and psychiatric diagnoses were confirmed by the Mini-International Neuropsychiatric Interview (M.I.N.I.). PA, home presenteeism and other social-clinical factors were captured by standard self-administered questionnaires.
   Results: Higher PA levels were associated with lower PHP (adjusted) among depressive patients with (p < 0.001) and without clinical depression (p = 0.021). In addition, DS (adjusted BDI) correlated with PHP (r = 0.60, 95% Cl: 0.56-0.65) in such a way that the higher the BDI was, the higher the PHP was. Moreover, home presenteeism were higher among depression diagnosed participants than those without (p = 0.002).
   Conclusion: According to this study, PA is associated with PHP among depressive patients in the Finnish adult population. PA seems to promote the ability to cope better with daily activitie sat home despite DS or a depression diagnosis. These findings outline the importance of being physically active regarding independency of daily activities, and thus, should be considered in clinical practices when treating depressive patients. (C) 2020 Asociacion Universitaria de Zaragoza para el Progreso de la Psiquiatria y la Salud Mental. Published by Elsevier Espana, S.L.U. All rights reserved.
C1 [Raatikainen, I; Heinonen, A.] Univ Jyvaskyla, Fac Sport & Hlth Sci, POB 35, FI-40014 Jyvaskyla, Finland.
   [Raatikainen, I] Assist Technol Ctr, Cent Finland Hlth Care Dist, Jyvaskyla, Finland.
   [Vanhala, M.; Mantyselka, P.] Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland.
   [Mantyselka, P.; Kautiainen, H.] Kuopio Univ Hosp, Primary Hlth Care Unit, Kuopio, Finland.
   [Kautiainen, H.] Folkhalsan Res Ctr, Helsinki, Finland.
   [Koponen, H.] Univ Helsinki, Dept Psychiat, Old Age Psychiat, Helsinki, Finland.
   [Koponen, H.] Helsinki Univ Hosp, Psychiat, Helsinki, Finland.
   [Korniloff, K.] JAMK Univ Appl Sci, Sch Hlth & Social Studies, Jyvaskyla, Finland.
C3 University of Jyvaskyla; Central Finland Central Hospital; University of
   Eastern Finland; University of Eastern Finland; University of Eastern
   Finland Hospital; Kuopio University Hospital; Folkhalsan Research
   Center; University of Helsinki; University of Helsinki; Helsinki
   University Central Hospital; Jyvaskyla University of Applied Sciences
RP Raatikainen, I (corresponding author), Univ Jyvaskyla, Fac Sport & Hlth Sci, POB 35, FI-40014 Jyvaskyla, Finland.
EM ilkka.t.raatikainen@student.jyu.fi
RI ; Heinonen, Ari/A-9199-2014
OI Koponen, Hannu/0000-0002-7368-1869; Raatikainen,
   Ilkka/0000-0002-4040-9666; Heinonen, Ari/0000-0002-3681-9953
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NR 46
TC 1
Z9 1
U1 2
U2 6
PU ELSEVIER ESPANA SLU
PI BARCELONA
PA AV JOSEP TARRADELLAS, 20-30, 1ERA PLANTA, BARCELONA, CP-08029, SPAIN
SN 0213-6163
J9 EUR J PSYCHIAT
JI Eur. J. Psychiat.
PD APR-JUN
PY 2021
VL 35
IS 2
BP 75
EP 82
DI 10.1016/j.ejpsy.2020.12.005
EA APR 2021
PG 8
WC Psychiatry
WE Social Science Citation Index (SSCI)
SC Psychiatry
GA TY6LA
UT WOS:000683892500002
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Ko, SH
   Baeg, MK
   Han, KD
   Ko, SH
   Ahn, YB
AF Ko, Sun-Hye
   Baeg, Myong Ki
   Han, Kyung-Do
   Ko, Seung-Hyun
   Ahn, Yu-Bae
TI Increased liver markers are associated with higher risk of type 2
   diabetes
SO WORLD JOURNAL OF GASTROENTEROLOGY
LA English
DT Article
DE Type 2 diabetes mellitus; Liver markers; Impaired fasting glucose;
   Gamma-glutamyl transferase; Aspartate aminotransferase; Alanine
   aminotransferase
ID GAMMA-GLUTAMYL-TRANSFERASE; INSULIN-RESISTANCE SYNDROME; KOREA
   NATIONAL-HEALTH; AGED JAPANESE MEN; METABOLIC SYNDROME; ALANINE
   AMINOTRANSFERASE; OXIDATIVE STRESS; FATTY LIVER; UPPER LIMITS; DISEASE
AB AIM: To investigate the association between liver markers and the risk of type 2 diabetes (T2DM) and impaired fasting glucose (IFG).
   METHODS: A total of 8863 participants (3408 men and 5455 women) over 30 years of age were analyzed from the fifth Korean National Health and Nutrition Examination Survey (2010-2011). The associations of serum liver markers such as aspartate aminotransferase (AST), alanine aminotransferase (ALT), AST/ALT, and gamma-glutamyltransferase (GGT) with T2DM and IFG were analyzed using logistic regression models. Participants were divided into sex-specific quartiles on the basis of liver markers.
   RESULTS: The prevalence of T2DM and IFG were 11.3% and 18.3%. Increasing quartiles of ALT and GGT were positively and AST/ALT were negatively correlated with T2DM and IFG. Analysis of the liver marker combinations showed that if any two or more markers were in the highest risk quartile, the risks of both T2DM and IFG increased significantly. The risk was greatest when the highest ALT and GGT and lowest AST/ALT quartile were combined, with the risk of T2DM at 3.21 (95% CI: 1.829-5.622, P < 0.001) in men and 4.60 (95% CI: 3.217-6.582, P < 0.001) in women. Men and women with the highest AST and ALT and lowest AST/ALT quartile had a 1.99 and 2.40 times increased risk of IFG.
   CONCLUSION: Higher levels of GGT and ALT and lower AST/ALT within the physiological range are independent, additive risk factors of T2DM and IFG.
C1 [Ko, Sun-Hye; Ko, Seung-Hyun; Ahn, Yu-Bae] Catholic Univ Korea, Coll Med, Dept Internal Med, Div Endocrinol & Metab, Seoul 137701, South Korea.
   [Baeg, Myong Ki] Catholic Univ Korea, Coll Med, Dept Internal Med, Div Gastroenterol, Seoul 137701, South Korea.
   [Han, Kyung-Do] Catholic Univ Korea, Coll Med, Dept Biostat, Seoul 137701, South Korea.
C3 Catholic University of Korea; Catholic University of Korea; Catholic
   University of Korea
RP Ahn, YB (corresponding author), Catholic Univ Korea, Coll Med, St Vincents Hosp, Dept Internal Med,Div Endocrinol & Metab, 222 Banpodaero, Seoul 137701, South Korea.
EM yoonk@catholic.ac.kr
RI Han, Kyungdo/JKH-7628-2023; Ko, Sun Hye/AGQ-5472-2022; Baeg, Myong
   Ki/O-1531-2017
OI Ko, Sun Hye/0000-0003-3387-3986; Baeg, Myong Ki/0000-0002-4807-2447
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NR 39
TC 49
Z9 52
U1 2
U2 10
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 8226 REGENCY DR, PLEASANTON, CA 94588 USA
SN 1007-9327
EI 2219-2840
J9 WORLD J GASTROENTERO
JI World J. Gastroenterol.
PD JUN 28
PY 2015
VL 21
IS 24
BP 7478
EP 7487
DI 10.3748/wjg.v21.i24.7478
PG 10
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA CL4LS
UT WOS:000356924900014
PM 26139993
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Wingo, BC
   Rinker, JR
   Goss, AM
   Green, K
   Wicks, V
   Cutter, GR
   Motl, RW
AF Wingo, Brooks C.
   Rinker, John R.
   Goss, Amy M.
   Green, Kathryn
   Wicks, Victoria
   Cutter, Gary R.
   Motl, Robert W.
TI Feasibility of improving dietary quality using a telehealth lifestyle
   intervention for adults with multiple sclerosis
SO MULTIPLE SCLEROSIS AND RELATED DISORDERS
LA English
DT Article
DE Multiple Sclerosis; Diet; Telehealth; Outcomes; Cardiometabolic risk
ID GLYCEMIC LOAD; PHYSICAL-ACTIVITY; FUNCTIONAL COMPOSITE; CARBOHYDRATE
   DIET; BODY-COMPOSITION; SAMPLE-SIZE; FAT DIET; EXERCISE; INDEX;
   DEPRESSION
AB Background: Evidence from observational studies increasingly highlights the association between unhealthy diet and poor health outcomes in adults with multiple sclerosis (MS), but very few intervention trials for dietary change have been completed. Improving diet quality via a low glycemic load (GL) diet has demonstrated improvements in cardiometabolic risks, cognitive risks, and psychosocial variables in diseases other than MS. The purpose of this study was to test the feasibility of delivering a low GL dietary intervention implemented via telehealth in a sample of adults with relapsing remitting MS (RRMS). The secondary purpose was to explore the potential impact of the diet on MS outcomes and cardiometabolic risks.
   Methods: Participants followed a low GL diet consisting of 100g of carbohydrate and GL of <= 45 points/1000 kcal daily for 12 weeks. Each participant received weekly calls from a telecoach, education and behavioral supports via weekly emails, and recorded all food intake on a mobile app. Feasibility was measured as time to recruit, retention and study completion, and intervention adherence. An a priori cut point of 80% completion was used to determine feasibility. Exploratory outcomes included the Multiple Sclerosis Functional Composite (MSFC) and patient-reported outcomes of anxiety, pain, mood, and fatigue. Cardiometabolic risks included body composition, fasting glucose, hemoglobin A1c, and blood pressure.
   Results: Twenty adults with RRMS (85% female, 50% African American) enrolled in the study and n=18 (90%) completed the intervention and follow-up measures. Participants completed 90% of scheduled calls and recorded at least one meal on 82% of intervention days (mean (SD) = 68 (25.5) days). Participants exceeded recommended daily GL reductions (recommended daily GL: 96.66 (12.97) points, reported follow-up daily GL: 90.32 (39.36) points). Timed 25-foot walk test and symbol digit modalities test both changed in the desired direction. Sleep, mood, anxiety, emotional health, and pain all moved in the expected directions, and anxiety (r=.24), pain (r=-.43), and emotional health (r=-.36) were moderately correlated with reductions in GL. Participants lost a mean of 2.93 (6.31, p=.003) kg, and had reductions in both fat and lean mass (fat mass: 1.94 (2.5) kg; lean mass: .72 (1.29) kg).
   Conclusion: A low GL dietary intervention is feasible for adults with RRMS and may lead to improvements in MS outcomes and cardiometabolic risk. Additional research is needed with more tightly controlled feeding trials and larger sample sizes to further understand the impact of this dietary pattern on RRMS.
C1 [Wingo, Brooks C.; Green, Kathryn; Wicks, Victoria] Univ Alabama Birmingham, Sch Hlth Profess, Dept Occupat Therapy, Birmingham, AL 32594 USA.
   [Rinker, John R.] Univ Alabama Birmingham, Sch Med, Dept Neurol, Birmingham, AL 32594 USA.
   [Goss, Amy M.] Univ Alabama Birmingham, Sch Hlth Profess, Dept Nutr Sci, Birmingham, AL 32594 USA.
   [Cutter, Gary R.] Univ Alabama Birmingham, Sch Publ Hlth, Dept Biostat, Birmingham, AL 32594 USA.
   [Motl, Robert W.] Univ Alabama Birmingham, Sch Hlth Profess, Dept Phys Therapy, Birmingham, AL 32594 USA.
C3 University of Alabama System; University of Alabama Birmingham;
   University of Alabama System; University of Alabama Birmingham;
   University of Alabama System; University of Alabama Birmingham;
   University of Alabama System; University of Alabama Birmingham;
   University of Alabama System; University of Alabama Birmingham
RP Wingo, BC (corresponding author), Univ Alabama Birmingham, 1720 2nd Ave S Birmingham, Birmingham, AL 32594 USA.
EM bcwingo@uab.edu; jrinker@uabmc.edu; amymiski@uab.edu;
   kathryngreen@uabmc.edu; vwicks@uab.edu; cutterg@uab.edu; robmotl@uab.edu
RI Cutter, Gary/AAY-5392-2021; Goss, Amy/GQI-4501-2022
OI Goss, Amy/0000-0001-8772-2935; Wingo, Brooks/0000-0001-8293-4824;
   Cutter, Gary/0000-0002-8455-980X; Rinker, John/0000-0002-8160-5268
FU National Multiple Sclerosis Society [PP-1706-27972]; UAB Center for
   Disability, Health, and Rehabilitation Science
FX This work was supported by the National Multiple Sclerosis Society
   [grant number PP-1706-27972], and the UAB Center for Disability, Health,
   and Rehabilitation Science.
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NR 68
TC 14
Z9 14
U1 0
U2 7
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 2211-0348
EI 2211-0356
J9 MULT SCLER RELAT DIS
JI Mult. Scler. Relat. Disord.
PD NOV
PY 2020
VL 46
AR 102504
DI 10.1016/j.msard.2020.102504
PG 8
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology
GA PC9IZ
UT WOS:000597312300017
PM 32942117
DA 2025-06-11
ER

PT J
AU Almulla, AF
   Thipakorn, Y
   Algon, AAA
   Tunvirachaisakul, C
   Al-Hakeim, HK
   Maes, M
AF Almulla, Abbas F.
   Thipakorn, Yanin
   Algon, Ali Abbas Abo
   Tunvirachaisakul, Chavit
   Al-Hakeim, Hussein K.
   Maes, Michael
TI Reverse cholesterol transport and lipid peroxidation biomarkers in major
   depression and bipolar disorder: A systematic review and meta-analysis
SO BRAIN BEHAVIOR AND IMMUNITY
LA English
DT Review
DE Oxidative and nitrosative stress; Antioxidants; Depression; Affective
   disorders; Neuro-immune; Autoimmunity
ID DENSITY-LIPOPROTEIN CHOLESTEROL; KAPPA-B ACTIVATION; OXIDATIVE STRESS;
   NITROSATIVE STRESS; COENZYME Q(10); AUTOIMMUNE RESPONSES; METABOLIC
   SYNDROME; VITAMIN-E; CARDIOVASCULAR DISORDER; INSULIN-RESISTANCE
AB Background: Major depression (MDD) and bipolar disorder (BD) are linked to immune activation, increased oxidative stress, and lower antioxidant defenses. Objectives: To systematically review and meta-analyze all data concerning biomarkers of reverse cholesterol transport (RCT), lipid-associated antioxidants, lipid peroxidation products, and autoimmune responses to oxidatively modified lipid epitopes in MDD and BD. Methods: Databases including PubMed, Google scholar and SciFinder were searched to identify eligible studies from inception to January 10th, 2023. Guidelines of Preferred Reporting Items for Systematic Reviews and Meta Analyses (PRISMA) guidelines were followed. Results: The current meta-analysis included 176 studies (60 BD and 116 MDD) and examined 34,051 participants, namely 17,094 with affective disorders and 16,957 healthy controls. Patients with MDD and BD showed a) significantly decreased RCT (mainly lowered high-density lipoprotein cholesterol and paraoxonase 1); b) lowered lipid soluble vitamins (including vitamin A, D, and coenzyme Q10); c) increased lipid peroxidation and aldehyde formation, mainly increased malondialdehyde (MDA), 4-hydroxynonenal, peroxides, and 8-isoprostanes; and d) Immunoglobulin (Ig)G responses to oxidized low-density lipoprotein and IgM responses to MDA. The ratio of all lipid peroxidation biomarkers/all lipid-associated antioxidant defenses was significantly increased in MDD (standardized mean difference or SMD = 0.433; 95% confidence intervals (CI): 0.312; 0.554) and BD (SMD = 0.653; CI: 0.501-0.806). This ratio was significantly greater in BD than MDD (p = 0.027).
C1 [Almulla, Abbas F.; Thipakorn, Yanin; Tunvirachaisakul, Chavit; Maes, Michael] Chulalongkorn Univ, Fac Med, Dept Psychiat, Bangkok, Thailand.
   [Almulla, Abbas F.] Islamic Univ, Coll Med Technol, Med Lab Technol Dept, Najaf, Iraq.
   [Algon, Ali Abbas Abo] Iraqi Educ Minist, Najaf, Iraq.
   [Tunvirachaisakul, Chavit; Maes, Michael] Chulalongkorn Univ, Fac Med, Cognit Impairment & Dementia Res Unit, Bangkok, Thailand.
   [Al-Hakeim, Hussein K.] Univ Kufa, Coll Sci, Dept Chem, Kufa, Iraq.
   [Maes, Michael] Med Univ Plovdiv, Dept Psychiat, Plovdiv, Bulgaria.
   [Maes, Michael] Med Univ Plovdiv, Res Inst, Plovdiv, Bulgaria.
   [Maes, Michael] Deakin Univ, IMPACT Strateg Res Ctr, Dept Psychiat, Geelong, Vic, Australia.
   [Maes, Michael] Kyung Hee Univ, 26 Kyungheedae Ro, Seoul 02447, South Korea.
   [Maes, Michael] Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Dept Ctr Psychosomat Med, Sichuan Prov Ctr Mental Hlth,Sch Med, Chengdu 610072, Peoples R China.
   [Maes, Michael] Chinese Acad Med Sci, Key Lab Psychosomat Med, Chengdu 610072, Peoples R China.
   [Maes, Michael] Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Dept Ctr Psychosomat Med, Sichuan Prov Ctr Mental Hlth,Sch Med, Chengdu 610072, Peoples R China.
C3 Chulalongkorn University; Islamic University College; Chulalongkorn
   University; University of Kufa; Medical University Plovdiv; Medical
   University Plovdiv; Deakin University; Kyung Hee University; University
   of Electronic Science & Technology of China; Sichuan Provincial People's
   Hospital; Chinese Academy of Medical Sciences - Peking Union Medical
   College; Sichuan Provincial People's Hospital; University of Electronic
   Science & Technology of China
RP Maes, M (corresponding author), Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Dept Ctr Psychosomat Med, Sichuan Prov Ctr Mental Hlth,Sch Med, Chengdu 610072, Peoples R China.
EM Yanin.T@chula.ac.th; dr.michaelmaes@hotmail.com
RI Almulla, Abbas F./ABG-7926-2020; Al-Hakeim, Hussein/G-1151-2011; Maes,
   Michael/B-8546-2011; Almulla, Abbas F./G-7975-2018
OI Almulla, Abbas F./0000-0002-7667-6731; Maes, Michael/0000-0002-2012-871X
FU C2F program, Chulalongkorn University, Thailand [64.310/436/2565]; FF66
   grant; Sompoch Endowment Fund (Faculty of Medicine), MDCU [RA66/016]
FX The study was funded by the C2F program, Chulalongkorn University,
   Thailand, No. 64.310/436/2565 to AFA, and an FF66 grant and a Sompoch
   Endowment Fund (Faculty of Medicine), MDCU (RA66/016) to MM.
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NR 119
TC 29
Z9 30
U1 3
U2 12
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0889-1591
EI 1090-2139
J9 BRAIN BEHAV IMMUN
JI Brain Behav. Immun.
PD OCT
PY 2023
VL 113
BP 374
EP 388
DI 10.1016/j.bbi.2023.08.007
EA AUG 2023
PG 15
WC Immunology; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Neurosciences & Neurology; Psychiatry
GA AZ9E2
UT WOS:001122376600001
PM 37557967
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Jackson, Y
   Castillo, S
   Hammond, P
   Besson, M
   Brawand-Bron, A
   Urzola, D
   Gaspoz, JM
   Chappuis, F
AF Jackson, Yves
   Castillo, Sara
   Hammond, Perle
   Besson, Marius
   Brawand-Bron, Anne
   Urzola, Diana
   Gaspoz, Jean-Michel
   Chappuis, Francois
TI Metabolic, mental health, behavioural and socioeconomic characteristics
   of migrants with Chagas disease in a non-endemic country
SO TROPICAL MEDICINE & INTERNATIONAL HEALTH
LA English
DT Article
DE Chagas disease; migrants; Europe; risk factors; prevention;
   cardiovascular disease; maladie de Chagas; migrants; Europe; facteurs de
   risque; prevention; maladies cardiovasculaires; enfermedad de Chagas;
   emigrantes; Europa; factores de riesgo; prevencion; enfermedad
   cardiovascular
ID LATIN-AMERICAN MIGRANTS; ALL-CAUSE MORTALITY; CARDIOVASCULAR RISK;
   TRANSMISSION; SWITZERLAND; PREVALENCE; CHALLENGE; PROFILE; CITIES
AB Objectives Chronic Chagas disease causes cardiopathy in 2040% of the 810 million people affected. The prevalence of atherogenic factors increases rapidly in Latin America. Somatic, mental, behavioural and social characteristics of the 80 000 Latino migrants with Chagas disease in Europe are not known. We postulate that they may accumulate these factors for poor health notably cardiovascular-outcomes. methods This study took place at the Geneva University Hospitals in 2011. Latin American migrants with Chagas disease diagnosed in Geneva since 2008 were contacted. Interviews and blood tests assessed behavioural, socioeconomic, metabolic and cardiovascular factors. results One hundred and thirty-seven patients (women: 84.7%; median age: 43 years) with chronic Chagas disease were included in the study. The majority were Bolivians (94.2%), undocumented (83.3%), uninsured (72.3%) and living below the Swiss poverty line (89.1%). Prevalence of obesity was 25.5%, of hypertension 17.5%, of hypercholesterolemia 16.1%, of impaired fasting glucose 23.4%, of diabetes 2.9%, of metabolic syndrome 16.8%, of anxiety 58.4%, of depression 28.5%, of current smoking 15.4% and of sedentary lifestyle 62.8%. High (> 10%) 10-year cardiovascular risk affected 12.4%. conclusions Latin American migrants with Chagas disease accumulate pathogenic chronic conditions of infectious, non-transmissible, socioeconomic and behavioural origin, putting them at high risk of poor health, notably cardiovascular, outcomes. This highlights the importance of screening for these factors and providing interventions to tackle reversible disorders; facilitating access to care for this hard-toreach population to prevent delays in medical interventions and poorer health outcomes; and launching prospective studies to evaluate the long-term impact of these combined factors on the natural course of Chagas disease.
C1 [Jackson, Yves] Univ Hosp Geneva, Div Primary Care Med, Dept Community Med Primary Care & Emergency Med, CH-1211 Geneva 14, Switzerland.
   [Castillo, Sara; Hammond, Perle] Geneva Med Sch Univ, Geneva, Switzerland.
   [Chappuis, Francois] Univ Hosp Geneva, Div Int & Humanitarian Med, CH-1211 Geneva 14, Switzerland.
C3 University of Geneva; University of Geneva; University of Geneva
RP Jackson, Y (corresponding author), Univ Hosp Geneva, Div Primary Care Med, Dept Community Med Primary Care & Emergency Med, Rue Gabrielle Perret Gentil 6, CH-1211 Geneva 14, Switzerland.
EM yves.jackson@hcuge.ch
RI Jackson, Yves/HMD-4215-2023
OI Chappuis, Francois/0000-0003-0442-7610; Jackson,
   Yves/0000-0001-5619-333X
FU Foundation Simon I. Patino in Geneva, Switzerland
FX This study was supported by a grant from the Foundation Simon I. Patino
   in Geneva, Switzerland.
CR Andrade F, 2009, REV PANAM SALUD PUBL, V26, P9, DOI 10.1590/S1020-49892009000700002
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NR 36
TC 29
Z9 31
U1 0
U2 16
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1360-2276
EI 1365-3156
J9 TROP MED INT HEALTH
JI Trop. Med. Int. Health
PD MAY
PY 2012
VL 17
IS 5
BP 595
EP 603
DI 10.1111/j.1365-3156.2012.02965.x
PG 9
WC Public, Environmental & Occupational Health; Tropical Medicine
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; Tropical Medicine
GA 928RU
UT WOS:000303001900008
PM 22487303
OA Bronze
DA 2025-06-11
ER

PT J
AU van Sprang, ED
   Maciejewski, DF
   Giltay, EJ
   Hartman, CA
   Penninx, BWJH
   Milaneschi, Y
AF van Sprang, Eleonore D.
   Maciejewski, Dominique F.
   Giltay, Erik J.
   Hartman, Catharina A.
   Penninx, Brenda W. J. H.
   Milaneschi, Yuri
TI Weighing poor immunometabolic health in relatives for severity of
   affective symptoms: A study of patients with depressive and anxiety
   disorders and their siblings
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE Siblings; Affective disorders; Metabolic syndrome; Cardiovascular;
   Inflammation; Heterogeneity
ID C-REACTIVE PROTEIN; FAMILIAL AGGREGATION; METABOLIC SYNDROME; MOOD
   DISORDERS; METAANALYSIS; INVENTORY; ASSOCIATION; PREVALENCE; DISEASE;
   SYMPTOMATOLOGY
AB Background: Affective (i.e. depressive and anxiety) disorders often co-occur with immunometabolic diseases and related biological pathways. Although many large population-based and meta-analytic studies have confirmed this link in community and clinical samples, studies in at-risk samples of siblings of persons with affective disorders are lacking. Furthermore, this somatic-mental co-occurrence may be partially explained by familial clustering of the conditions. First, we examined whether the association between a wide range of immunometabolic diseases and related biomarker based risk-profiles with psychological symptoms replicates in at-risk siblings of probands with affective disorders. Second, leveraging on a sibling-pair design, we disentangled and quantified the effect of probands' immunometabolic health on siblings' psychological symptoms and on the association between immunometabolic health and these symptoms in siblings.Methods: The sample included 636 participants (Mage = 49.7; 62.4% female) from 256 families, each including a proband with lifetime depressive and/or anxiety disorders and at least one of their sibling(s) (N = 380 probandsibling pairs). Immunometabolic health included cardiometabolic and inflammatory diseases, body mass index (BMI), and composite metabolic (based on the five metabolic syndrome components) and inflammatory (based on interleukin-6 and C-reactive protein) biomarker indices. Overall affective symptoms and specific atypical, energy-related depressive symptoms were derived from self-report questionnaires. Mixed-effects analyses were used to model familial clustering.Results: In siblings, inflammatory disease (& gamma; = 0.25, p = 0.013), higher BMI (& gamma; = 0.10, p = 0.033) and metabolic index (& gamma; = 0.28, p < 0.001) were associated with higher affective symptoms, with stronger associations for atypical, energy-related depressive symptoms (additionally associated with cardiometabolic disease; & gamma; = 0.56, p = 0.048). Immunometabolic health in probands was not independently associated with psychological symptoms in siblings nor did it moderate the association between immunometabolic health and psychological symptoms estimated in siblings.Conclusions: Our findings demonstrate that the link between later life immunometabolic health and psychological symptoms is consistently present also in adult siblings at high risk for affective disorders. Familial clustering did not appear to have a substantial impact on this association. Instead, individual lifestyle, rather than familial factors, may have a relatively higher impact in the clustering of later life immunometabolic conditions with psychological symptoms in at-risk adult individuals. Furthermore, results highlighted the importance of focusing on specific depression profiles when investigating the overlap with immunometabolic health.
C1 [van Sprang, Eleonore D.; Penninx, Brenda W. J. H.; Milaneschi, Yuri] Amsterdam UMC Locat Vrije Univ Amsterdam, Amsterdam Publ Hlth Res Inst, Dept Psychiat, Amsterdam, Netherlands.
   [Maciejewski, Dominique F.] Tilburg Univ, Tilburg Sch Social & Behav Sci, Dept Dev Psychol, Tilburg, Netherlands.
   [Giltay, Erik J.] Leiden Univ, Med Ctr, Dept Psychiat, Leiden, Netherlands.
   [Hartman, Catharina A.] Univ Groningen, Univ Med Ctr Groningen, Interdisciplinary Ctr Psychopathol & Emot regulat, Dept Psychiat, Groningen, Netherlands.
C3 Vrije Universiteit Amsterdam; Tilburg University; Leiden University;
   Leiden University Medical Center (LUMC); Leiden University - Excl LUMC;
   University of Groningen
RP van Sprang, ED; Milaneschi, Y (corresponding author), Amsterdam UMC Locat Vrije Univ Amsterdam, Amsterdam Publ Hlth Res Inst, Dept Psychiat, Amsterdam, Netherlands.
EM eleonorevansprang@gmail.com; y.milaneschi@amsterdamumc.nl
RI Maciejewski, Dominique/IYS-9234-2023; Giltay, Erik/AAL-9948-2021;
   Penninx, Brenda/S-7627-2017
OI Milaneschi, Yuri/0000-0002-3697-6617; Giltay, Erik
   J./0000-0001-8874-2292
FU Netherlands Study of Depression and Anxiety (NESDA); Geestkracht program
   of the Netherlands Organization for Scientific Research and Development
   (ZonMw) [10-000-1002]; Amsterdam University Medical-Vrije Universiteit
   VU; GGZ ingeest; Leiden University Medical Center; Leiden University;
   GGZ Rivierduinen; University Medical Center Groningen; University of
   Groningen; Lentis; GGZ Friesland; GGZ Drenthe; Dimence; Rob Giel
   Onderzoekscentrum; NWO (VICI) [91811602]; Janssen Research amp;
   Development, LLC, Titusville, NJ, USA
FX The Netherlands Study of Depression and Anxiety (NESDA; www.nesda.nl) is
   funded through the Geestkracht program of the Netherlands Organization
   for Scientific Research and Development (ZonMw, grant number
   10-000-1002) and financial contributions by participating universities
   and mental health care organizations (Amsterdam University Medical-Vrije
   Universiteit VU, GGZ ingeest, Leiden University Medical Center, Leiden
   University, GGZ Rivierduinen, University Medical Center Groningen,
   University of Groningen, Lentis, GGZ Friesland, GGZ Drenthe, Dimence,
   Rob Giel Onderzoekscentrum) . Data analyses and biomarker assays were
   partly funded through NWO funding (VICI, Grant No. 91811602) and through
   grant support from Janssen Research & Development, LLC, Titusville, NJ,
   USA. The funders did not have direct access to the data and were not
   involved in the conduct of the data collection, management and analyses.
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NR 79
TC 0
Z9 0
U1 1
U2 1
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
EI 1873-3360
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD OCT
PY 2023
VL 156
AR 106326
DI 10.1016/j.psyneuen.2023.106326
EA JUN 2023
PG 11
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA M2VW2
UT WOS:001028817800001
PM 37393801
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Chin, B
   Murphy, MLM
   Janicki-Deverts, D
   Cohen, S
AF Chin, Brian
   Murphy, Michael L. M.
   Janicki-Deverts, Denise
   Cohen, Sheldon
TI Marital status as a predictor of diurnal salivary cortisol levels and
   slopes in a community sample of healthy adults
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE Salivary cortisol; Marital status; Stress buffering; Diurnal slopes
ID PITUITARY-ADRENOCORTICAL AXIS; METABOLIC SYNDROME; SOCIAL SUPPORT;
   STRESS; RISK; SUSCEPTIBILITY; VARIABILITY; PERSONALITY; RELIABILITY;
   DISSOLUTION
AB Married people tend to be healthier than both the previously (bereaved, divorced, and separated) and never married, but the mechanisms through which this occurs remain unclear. To this end, research has increasingly focused on how psychological stress experienced by unmarried versus married individuals may differentially impact physiological systems related to health. One key system that is modulated by stress is the hypothalamic-pituitary-adrenal (HPA) axis, of which cortisol is a key hormonal product. Increased cortisol production and disruption of cortisol's daily rhythm have been linked to poorer health outcomes. This study examined the association between current marital status and these two indices of cortisol in a community sample of 572 healthy men and women aged 21-55. It also tested whether marriage buffers against the effect of stress (perceived stress by marital status interaction) on cortisol production. Participants provided salivary cortisol samples during waking hours on three nonconsecutive separate days to calculate diurnal cortisol levels and slopes. Married individuals had lower cortisol levels than either their never married or previously married counterparts. Differences in cortisol levels were due at least in part to currently married individuals having a more rapid decline in cortisol through the afternoon hours compared to individuals who were never married (but not those who were previously married). Furthermore, there was an interaction between perceived stress and marital status in predicting cortisol levels. Specifically, higher stress was associated with higher cortisol levels for previously married individuals but not for the married or never married. The results of this study support cortisol as one candidate mechanism accounting for the association of marital status and health. (C) 2017 Elsevier Ltd. All rights reserved.
C1 [Chin, Brian; Murphy, Michael L. M.; Cohen, Sheldon] Carnegie Mellon Univ, Dept Psychol, 5000 Forbes Ave, Pittsburgh, PA 15213 USA.
   [Janicki-Deverts, Denise] Univ Pittsburgh, Sch Dent Med, 3501 Terrance St, Pittsburgh, PA 15261 USA.
C3 Carnegie Mellon University; Pennsylvania Commonwealth System of Higher
   Education (PCSHE); University of Pittsburgh
RP Cohen, S (corresponding author), Carnegie Mellon Univ, Dept Psychol, 5000 Forbes Ave, Pittsburgh, PA 15213 USA.
EM scohen@cmu.edu
RI Chin, Brian/GPS-4971-2022
OI Chin, Brian/0000-0003-4643-0172
FU National Center for Complementary and Integrative Health [AT006694];
   National Institute of Mental Health [MH50429]; National Heart, Lung, and
   Blood Institute [HL65111, HL65112]; National Institute for Allergy and
   Infectious Diseases [R01 AI066367]; National Institutes of Health
   [NCRR/GCRC 5M01 RR00056, UL1 RR024153, UL1 RT000005]
FX Preparation of this paper was supported by a grant from the National
   Center for Complementary and Integrative Health (AT006694); the conduct
   of the studies was supported by grants from the National Institute of
   Mental Health (MH50429), National Heart, Lung, and Blood Institute
   (HL65111; HL65112), and National Institute for Allergy and Infectious
   Diseases (R01 AI066367); and secondary support was provided by a grant
   from the National Institutes of Health to the University of Pittsburgh
   Medical Center General Clinical Research Center (NCRR/GCRC 5M01 RR00056)
   and from the National Institutes of Health to the University of
   Pittsburgh Clinical and Translational Science Institute (UL1 RR024153
   and UL1 RT000005); and supplemental support was provided by John D. and
   Catherine T. MacArthur Foundation Research Network on Socioeconomic
   Status & Health. We thank David Creswell and Brooke Feeney for their
   feedback on an earlier version of this manuscript.
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NR 54
TC 58
Z9 60
U1 0
U2 11
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
EI 1873-3360
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD APR
PY 2017
VL 78
BP 68
EP 75
DI 10.1016/j.psyneuen.2017.01.016
PG 8
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA ER5UD
UT WOS:000398867900009
PM 28171850
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Zer-Aviv, TM
   Segev, A
   Akirav, I
AF Zer-Aviv, Tomer Mizrachi
   Segev, Amir
   Akirav, Irit
TI Cannabinoids and post-traumatic stress disorder: clinical and
   preclinical evidence for treatment and prevention
SO BEHAVIOURAL PHARMACOLOGY
LA English
DT Review
DE anxiety; cannabis; endocannabinoids; extinction; post-traumatic stress
   disorder; rat
ID CARDIOMETABOLIC RISK-FACTORS; USE COPING MOTIVES; ENDOCANNABINOID
   SYSTEM; ENDOGENOUS CANNABINOIDS; FEAR EXTINCTION; CB1 RECEPTORS;
   MARIJUANA USE; PREFRONTAL CORTEX; BRAIN CONSTITUENT; PTSD SYMPTOMS
AB There is substantial evidence from studies in humans and animal models for a role of the endocannabinoid system in the control of emotional states. Several studies have shown an association between exposure to trauma and substance use. Specifically, it has been shown that there is increased prevalence of cannabis use in post-traumatic stress disorder (PTSD) patients and vice versa. Clinical studies suggest that PTSD patients may cope with their symptoms by using cannabis. This treatment-seeking strategy may explain the high prevalence of cannabis use among individuals with PTSD. Preliminary studies in humans also suggest that treatment with cannabinoids may decrease PTSD symptoms including sleep quality, frequency of nightmares, and hyperarousal. However, there are no large-scale, randomized, controlled studies investigating this specifically. Studies in animal models have shown that cannabinoids can prevent the effects of stress on emotional function and memory processes, facilitate fear extinction, and have an anti-anxiety-like effect in a variety of tasks. Moreover, cannabinoids administered shortly after exposure to a traumatic event were found to prevent the development of PTSD-like phenotype. In this article, we review the existing literature on the use of cannabinoids for treating and preventing PTSD in humans and animal models. There is a need for large-scale clinical trials examining the potential decrease in PTSD symptomatology with the use of cannabis. In animal models, there is a need for a better understanding of the mechanism of action and efficacy of cannabis. Nevertheless, the end result of the current clinical and preclinical data is that cannabinoid agents may offer therapeutic benefits for PTSD. Copyright (C) 2016 Wolters Kluwer Health, Inc. All rights reserved.
C1 [Zer-Aviv, Tomer Mizrachi; Segev, Amir; Akirav, Irit] Univ Haifa, Dept Psychol, IL-3498838 Haifa, Israel.
C3 University of Haifa
RP Akirav, I (corresponding author), Univ Haifa, Dept Psychol, IL-3498838 Haifa, Israel.
EM irit.akirav@gmail.com
OI akirav, irit/0000-0002-7633-5953; Mizrachi - Zer-Aviv,
   Tomer/0009-0007-3275-5060
FU Israel Science Foundation [572/12]
FX This research was supported by The Israel Science Foundation
   (http://www.isf.org.il/, grant no. 572/12 to I.A.).
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NR 104
TC 33
Z9 39
U1 0
U2 41
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0955-8810
EI 1473-5849
J9 BEHAV PHARMACOL
JI Behav. Pharmacol.
PD OCT
PY 2016
VL 27
IS 7
BP 561
EP 569
DI 10.1097/FBP.0000000000000253
PG 9
WC Behavioral Sciences; Neurosciences; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Behavioral Sciences; Neurosciences & Neurology; Pharmacology & Pharmacy
GA DW1IW
UT WOS:000383397700001
PM 27551883
DA 2025-06-11
ER

PT J
AU Kurhe, Y
   Mahesh, R
   Devadoss, T
AF Kurhe, Yeshwant
   Mahesh, R.
   Devadoss, Thangaraj
TI Novel 5-HT3 receptor antagonist QCM-4 attenuates
   depressive-like phenotype associated with obesity in high-fat-diet-fed
   mice
SO PSYCHOPHARMACOLOGY
LA English
DT Article
DE Depression; Obesity; Serotonin; p53; BDNF
ID ELEMENT-BINDING PROTEIN; ANXIETY-LIKE BEHAVIOR; ELEVATED PLUS-MAZE; MILD
   STRESS CMS; INSULIN-RESISTANCE; HPA AXIS; HIPPOCAMPAL NEUROGENESIS;
   SEROTONIN TRANSPORTER; ANTIDEPRESSANT ACTION; METABOLIC SYNDROME
AB Rationale Depression associated with obesity remains an interesting area to study the biological mechanisms and novel therapeutic intervention.
   Objectives The present study investigates the effect of a novel 5-HT3 receptor antagonist 3-methoxy-N-p-tolylquinoxalin-2carboxamide (QCM-4) on several pathogenic markers of depression associated with obesity such as plasma insulin resistance, hippocampal cyclic adenosine monophosphate (cAMP), brain-derived neurotrophic factor (BDNF), serotonin (5-HT) concentrations, hippocampal neuronal damage, and p53 protein expression in high-fat-diet (HFD)-fed mice.
   Methods Obesity was experimentally induced inmice by feeding with HFD for 14 weeks followed by administration of QCM-4 (1 and 2 mg/kg, p.o.)/standard escitalopram (ESC) (10 mg/kg, p.o.)/vehicle (10 ml/kg, p.o.) for 28 days. Behavioral assays such as sucrose preference test (SPT); forced swim test (FST); elevated plus maze (EPM); biochemical assays including oral glucose tolerance tests (OGTT), insulin, cAMP, BDNF, and 5-HT concentrations; and molecular assays mainly histology and immunohistochemistry (IHC) of p53 protein in the dentate gyrus (DG), CA1, and CA3 regions of hippocampus in HFD fed mice were performed.
   Results Chronic treatment with QCM-4 in HFD-fed mice reversed the behavioral alterations in SPT, FST, and EPM. QCM-4 showed poor sensitivity for plasma glucose, improved insulin sensitivity, increased hippocampal cAMP, BDNF, and 5-HT concentrations. In the hippocampal DG, CA1, and CA3 regions, QCM-4 treatment improved the neuronal morphology in the histopathology and inhibited p53 protein expression in IHC assay in HFD-fed mice.
   Conclusion QCM-4 attenuated the depressive-like phenotype in HFD-fed mice by improving behavioral, biochemical, and molecular alterations through serotonergic neuromodulation.
C1 [Kurhe, Yeshwant; Mahesh, R.] Birla Inst Technol & Sci, Dept Pharm, Pilani Campus, Pilani 333031, Rajasthan, India.
   [Devadoss, Thangaraj] IMU, Sch Pharm, Dept Pharmaceut Chem, 126,Jalan Jalil Perkasa 19, Kuala Lumpur 57000, Malaysia.
C3 Birla Institute of Technology & Science Pilani (BITS Pilani);
   International Medical University Malaysia
RP Kurhe, Y (corresponding author), Birla Inst Technol & Sci, Dept Pharm, Pilani Campus, Pilani 333031, Rajasthan, India.
EM yashkurhe@gmail.com
RI Devadoss, Thangaraj/I-6287-2019
OI Devadoss, Thangaraj/0000-0002-2228-9357
FU Birla Institute of Technology and Science (BITS), Pilani, India
FX The authors are thankful to Birla Institute of Technology and Science
   (BITS), Pilani, India, for providing the support and research facilities
   to pursue this work.
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NR 65
TC 13
Z9 13
U1 1
U2 12
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0033-3158
EI 1432-2072
J9 PSYCHOPHARMACOLOGY
JI Psychopharmacology
PD APR
PY 2017
VL 234
IS 7
BP 1165
EP 1179
DI 10.1007/s00213-017-4558-0
PG 15
WC Neurosciences; Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA EQ8VS
UT WOS:000398364200011
PM 28238069
DA 2025-06-11
ER

PT J
AU Hayden, MR
   Whaley-Connell, A
   Sowers, JR
AF Hayden, MR
   Whaley-Connell, A
   Sowers, JR
TI Renal redox stress and remodeling in metabolic syndrome, type 2 diabetes
   mellitus, and diabetic nephropathy: Paying homage to the podocyte
SO AMERICAN JOURNAL OF NEPHROLOGY
LA English
DT Review
DE asymmetrical dimethylarginine; atherosclerosis; cardiorenal metabolic
   syndrome; glomerulosclerosis; microalbuminuria; NAD(P)H oxidase;
   oxidative stress; podocyte; reactive oxygen species
ID NITRIC-OXIDE SYNTHASE; GLYCATION END-PRODUCTS; OXIDATIVE STRESS;
   ANGIOTENSIN-II; INSULIN-RESISTANCE; ENDOTHELIAL DYSFUNCTION; NAD(P)H
   OXIDASE; FREE-RADICALS; FOLIC-ACID; DISEASE
AB Type 2 diabetes mellitus has reached epidemic proportions and diabetic nephropathy is the leading cause of end-stage renal disease. The metabolic syndrome constitutes a milieu conducive to tissue redox stress. This loss of redox homeostasis contributes to renal remodeling and parallels the concurrent increased vascular redox stress associated with the cardiometabolic syndrome. The multiple metabolic toxicities, redox stress and endothelial dysfunction combine to weave the complicated mosaic fabric of diabetic glomerulosclerosis and diabetic nephropathy. A better understanding may provide both the clinician and researcher tools to unravel this complicated disease process. Cellular remodeling of podocyte foot processes in the Ren-2 transgenic rat model of tissue angiotensin II overexpression (TG(mREN-2) 27) and the Zucker diabetic fatty model of type 2 diabetes mellitus have been observed in preliminary studies. Importantly, angiotensin II receptor blockers have been shown to abrogate these ultrastructural changes in the foot processes of the podocyte in preliminary studies. An integrated, global risk reduction, approach in therapy addressing the multiple metabolic abnormalities combined with attempts to reach therapeutic goals at an earlier stage could have a profound effect on the development and progressive nature to end-stage renal disease and ultimately renal replacement therapy. Copyright (C) 2005 S. Karger AG, Basel.
C1 Univ Missouri, Dept Internal Med,Sch Med, Div Endocrinol Diabet & Metab, Diabet & Cardiovasc Dis Ctr,Hlth Sci Ctr, Columbia, MO 65212 USA.
   Univ Missouri, Dept Physiol & Pharmacol, Sch Med, Columbia, MO 65212 USA.
C3 University of Missouri System; University of Missouri Columbia;
   University of Missouri System; University of Missouri Columbia
RP Univ Missouri, Dept Internal Med,Sch Med, Div Endocrinol Diabet & Metab, Diabet & Cardiovasc Dis Ctr,Hlth Sci Ctr, MA410,DC043-00, Columbia, MO 65212 USA.
EM mrh29@usmo.com
RI Hayden, Michael/D-8581-2011
OI Whaley-Connell, Adam/0000-0001-8955-5560
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NR 129
TC 63
Z9 68
U1 0
U2 3
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0250-8095
EI 1421-9670
J9 AM J NEPHROL
JI Am. J. Nephrol.
PY 2005
VL 25
IS 6
BP 553
EP 569
DI 10.1159/000088810
PG 17
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 993LF
UT WOS:000233954900005
PM 16210838
DA 2025-06-11
ER

PT J
AU Tully, PJ
   Baumeister, H
   Bengel, J
   Jenkins, A
   Januszewski, A
   Martin, S
   Wittert, GA
AF Tully, Phillip J.
   Baumeister, Harald
   Bengel, Juergen
   Jenkins, Alicia
   Januszewski, Andrzej
   Martin, Sean
   Wittert, Gary A.
TI The longitudinal association between inflammation and incident
   depressive symptoms in men: The effects of hs-CRP are independent of
   abdominal obesity and metabolic disturbances
SO PHYSIOLOGY & BEHAVIOR
LA English
DT Article
DE Depression; Inflammation; Abdominal adiposity; Longitudinal; C-reactive
   protein; Interleukin-6; Tumor necrosis factor-alpha; Obesity; Body mass
   index; Metabolic syndrome
ID C-REACTIVE PROTEIN; IMMUNE ACTIVATION; MAJOR DEPRESSION; LIFE-STYLE;
   METAANALYSIS; RISK; INTERLEUKIN-6; ANXIETY; HEALTHY; BRAIN
AB Background: This cohort study evaluates whether the association between low-grade inflammation and incident depressive symptoms is independent of abdominal obesity and metabolic disturbances.
   Methods: A cohort of 1167 non-depressed men aged 35 to 80 years were followed up over 5 years to assess incident depressive symptoms measured by the Centre for Epidemiology Scale Depression or Beck Depression Inventory-I. Venous tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and high sensitivity C-reactive protein (hsCRP) were quantified at baseline and 5 years. Logistic regression determined whether hsCRP, IL-6 and TNF-alpha were associated with incident depressive symptoms independent of abdominal obesity and metabolic factors. Ancillary analysis utilizing depression z scores stratified participants by waist circumference >= 102 cm and >= 2 metabolic disturbances.
   Results: Incident depressive symptoms occurred in 95 men at 5 years (8.14% of total). Clinically relevant depressive symptoms were associated with baseline hsCRP (adjusted OR = 1.04; 95% CI 1.00-1.07, p = .03) and annualized Delta hsCRP (adjusted OR = 1.04; 95% CI 1.01-1.08, p = .02). Ancillary analysis showed that the association between annualized Delta hsCRP and depression z score was only significant in men with waist circumference < 102 cm (beta = .19, p < .001) and <= 1 metabolic disturbance (beta =.18, p < .001). None of the measured cytokines were significantly associated with depression.
   Conclusions: hsCRP and annualized Delta hsCRP were positively associated with depressive symptoms in a cohort of men. Further investigation into the role of abdominal obesity and metabolic disturbances in the inflammation-depression hypothesis is warranted. (c) 2014 Elsevier Inc. All rights reserved.
C1 [Tully, Phillip J.; Martin, Sean; Wittert, Gary A.] Univ Adelaide, Sch Med, Discipline Med, Freemasons Fdn Ctr Mens Hlth, Adelaide, SA 5005, Australia.
   [Tully, Phillip J.; Baumeister, Harald; Bengel, Juergen] Univ Freiburg, Inst Psychol, Dept Rehabil Psychol & Psychotherapy, D-79106 Freiburg, Germany.
   [Baumeister, Harald] Univ Freiburg, Fac Med, D-79106 Freiburg, Germany.
   [Jenkins, Alicia; Januszewski, Andrzej] Univ Sydney, NHMRC Clin Trials Ctr, Sydney, NSW 2006, Australia.
C3 University of Adelaide; University of Freiburg; University of Freiburg;
   University of Sydney
RP Tully, PJ (corresponding author), Univ Adelaide, Sch Med, Discipline Med, Adelaide, SA 5005, Australia.
EM phillip.tully@adelaide.edu.au
RI wittert, gary/AAE-2398-2019; Januszewski, Andrzej/N-2006-2015; Jenkins,
   Alicia/N-2482-2015; Tully, Phillip/I-6256-2018
OI Tully, Phillip/0000-0003-2807-1313; Wittert, Gary/0000-0001-6818-6065;
   Jenkins, Alicia/0000-0003-0583-3717; Baumeister,
   Harald/0000-0002-2040-661X
FU National Health and Medical Research Council of Australia (NHMRC)
   [627227, 1053578]
FX This work was supported by the National Health and Medical Research
   Council of Australia (NHMRC Project Grant # 627227; NHMRC Clinical
   Overseas Fellowship # 1053578). The funding body had no role in the
   design and conduct of the study; in the collection, analysis, and
   interpretation of the data; or in the preparation, review, or approval
   of the manuscript.
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NR 60
TC 16
Z9 18
U1 0
U2 9
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0031-9384
J9 PHYSIOL BEHAV
JI Physiol. Behav.
PD FEB
PY 2015
VL 139
BP 328
EP 335
DI 10.1016/j.physbeh.2014.11.058
PG 8
WC Psychology, Biological; Behavioral Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Behavioral Sciences
GA CB4BY
UT WOS:000349574400045
PM 25460540
DA 2025-06-11
ER

PT J
AU Khoshakhlagh, AH
   Al Sulaie, S
   Yazdanirad, S
   Orr, RM
   Dehdarirad, H
   Milajerdi, A
AF Khoshakhlagh, Amir Hossein
   Al Sulaie, Saleh
   Yazdanirad, Saeid
   Orr, Robin Marc
   Dehdarirad, Hossein
   Milajerdi, Alireza
TI Global prevalence and associated factors of sleep disorders and poor
   sleep quality among firefighters: A systematic review and meta-analysis
SO HELIYON
LA English
DT Review
DE Global prevalence; Sleep disorders; Poor sleep quality; Firefighters;
   Systematic review; Meta-analysis
ID POSTTRAUMATIC-STRESS-DISORDER; BODY-MASS INDEX; KOREAN FIREFIGHTERS;
   METABOLIC SYNDROME; ALCOHOL-USE; BACK-PAIN; OF-LIFE; DISTURBANCES; WORK;
   DEPRESSION
AB Lack of sleep can affect the health and performance of firefighters. This systematic review and meta-analysis estimated the global prevalence of sleep disorders and poor sleep quality among firefighters and reported associated factors. Four academic databases (Scopus, PubMed, Web of Science, and Embase) were systematically searched from January 1, 2000 to January 24, 2022. These databases were selected as they are known to index studies in this field. The search al-gorithm included two groups of keywords and all possible combinations of these words. The first group included keywords related to sleep and the second group keywords related to the fire-fighting profession. The relevant Joanna Briggs Institute checklist was used to evaluate study quality. Data from eligible studies were included in a meta-analysis. In total, 47 articles informed this review. The pooled prevalence of sleep disorders and poor sleep quality in firefighters were determined as 30.49% (95% CI [25.90, 35.06]) and 51.43% (95% CI [42.76, 60.10]), respec-tively. The results of a subgroup analysis showed that individuals in low-and middle-income countries (LMICs) had a higher prevalence of sleep disorders than those in high-income coun-tries (HICs) but HICs had a higher prevalence of poor sleep quality than LMICs. Various factors, including shift work, mental health, injuries and pain, and body mass index were associated with sleep health. The findings of this review highlight the need for sleep health promotion programs in firefighters.
C1 [Khoshakhlagh, Amir Hossein] Kashan Univ Med Sci, Sch Hlth, Dept Occupat Hlth, Kashan, Iran.
   [Al Sulaie, Saleh] Umm Al Qura Univ, Coll Engn Al Qunfudah, Dept Ind Engn, Mecca 21955, Saudi Arabia.
   [Yazdanirad, Saeid] Shahrekord Univ Med Sci, Social Determinants Hlth Res Ctr, Shahrekord, Iran.
   [Yazdanirad, Saeid] Shahrekord Univ Med Sci, Sch Hlth, Shahrekord, Iran.
   [Orr, Robin Marc] Bond Univ, Tact Res Unit, Gold Coast, Australia.
   [Dehdarirad, Hossein] Univ Tehran Med Sci, Sch Allied Med Sci, Med Lib & Informat Sci, Tehran, Iran.
   [Milajerdi, Alireza] Kashan Univ Med Sci, Res Ctr Biochem & Nutr Metab Dis, Inst Basic Sci, Kashan, Iran.
   [Yazdanirad, Saeid] Shahrekord Univ Med Sci, Shahrekord, Iran.
C3 Umm Al-Qura University; Shahrekord University Medical Sciences;
   Shahrekord University Medical Sciences; Bond University; Tehran
   University of Medical Sciences; Shahrekord University Medical Sciences
RP Yazdanirad, S (corresponding author), Shahrekord Univ Med Sci, Shahrekord, Iran.
EM ah.khoshakhlagh@gmail.com; smsulaie@uqu.edu.sa;
   saeedyazdanirad@gmail.com; rorr@bond.edu.au; dehdari.hossein@gmail.com;
   miljerdi.a@gmail.com
RI Yazdanirad, Saeid/AAG-9039-2021; Orr, Robin/H-3757-2019; Milajerdi,
   Alireza/ABB-1854-2020; Dehdarirad, Hossein/H-6227-2011; khoshakhlagh,
   amirhossein/O-8171-2017
OI Dehdarirad, Hossein/0000-0002-6685-5429; Al Sulaie,
   Saleh/0009-0009-7883-2521; khoshakhlagh,
   amirhossein/0000-0002-2265-5054; Orr, Robin/0000-0001-8297-8288
FU Kashan University of Medical Sciences [IR.KAUMS.NUHEPM.REC.1400.044]
FX Funding statement Amir Hossein Khoshakhlagh was supported by Kashan
   University of Medical Sciences [IR.KAUMS.NUHEPM.REC.1400.044] .
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NR 95
TC 7
Z9 7
U1 2
U2 11
PU CELL PRESS
PI CAMBRIDGE
PA 50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA
EI 2405-8440
J9 HELIYON
JI Heliyon
PD FEB
PY 2023
VL 9
IS 2
AR e13250
DI 10.1016/j.heliyon.2023.e13250
EA FEB 2023
PG 16
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA D4PM0
UT WOS:000968567500001
PM 36798763
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Melikian, N
   De Bruyne, B
   Fearon, WF
   MacCarthy, PA
AF Melikian, Narbeh
   De Bruyne, Bernard
   Fearon, William F.
   MacCarthy, Philip A.
TI The pathophysiology and clinical course of the normal coronary angina
   syndrome (cardiac syndrome x)
SO PROGRESS IN CARDIOVASCULAR DISEASES
LA English
DT Review
ID ST-SEGMENT DEPRESSION; ELECTRICAL NERVE-STIMULATION;
   COGNITIVE-BEHAVIORAL THERAPY; LEFT-VENTRICULAR FUNCTION; SPINAL-CORD
   STIMULATION; CHEST-PAIN; FLOW RESERVE; MYOCARDIAL-ISCHEMIA;
   MICROVASCULAR ANGINA; POSTMENOPAUSAL WOMEN
C1 [Melikian, Narbeh; De Bruyne, Bernard; Fearon, William F.; MacCarthy, Philip A.] Kings Coll Hosp London, Dept Cardiol, London SE5 9RS, England.
   [Melikian, Narbeh; De Bruyne, Bernard; Fearon, William F.; MacCarthy, Philip A.] Kings Coll London, Guys Kings Coll, Sch Med, Div Cardiovasc Med, London WC2R 2LS, England.
   [Melikian, Narbeh; De Bruyne, Bernard; Fearon, William F.; MacCarthy, Philip A.] St Thomas Hosp, London, England.
   [Melikian, Narbeh; De Bruyne, Bernard; Fearon, William F.; MacCarthy, Philip A.] Onze Lieve Vrouw Hosp, Ctr Cardiovasc, Aalst, Belgium.
   [Melikian, Narbeh; De Bruyne, Bernard; Fearon, William F.; MacCarthy, Philip A.] Stanford Univ, Ctr Med, Ctr Res Cardiovasc Intervent, Stanford, CA 94305 USA.
C3 King's College Hospital NHS Foundation Trust; King's College Hospital;
   University of London; King's College London; Guy's & St Thomas' NHS
   Foundation Trust; Cardiovascular Center Aalst; Stanford University
RP MacCarthy, PA (corresponding author), Kings Coll Hosp London, Dept Cardiol, Denmark Hill, London SE5 9RS, England.
EM philip@maccarthy.co.uk
RI De Bruyne, Bernard/ACL-1718-2022
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NR 108
TC 29
Z9 31
U1 0
U2 3
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0033-0620
EI 1873-1740
J9 PROG CARDIOVASC DIS
JI Prog. Cardiovasc. Dis.
PD JAN-FEB
PY 2008
VL 50
IS 4
BP 294
EP 310
DI 10.1016/j.pcad.2007.01.003
PG 17
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 249DW
UT WOS:000252208300006
PM 18156008
DA 2025-06-11
ER

PT J
AU Garcés-Rimón, M
   González, C
   Hernanz, R
   Herradón, E
   Martín, A
   Palacios, R
   Alonso, MJ
   Uranga, JA
   López-Miranda, V
   Miguel, M
AF Garces-Rimon, Marta
   Gonzalez, Cristina
   Hernanz, Raquel
   Herradon, Esperanza
   Martin, Angela
   Palacios, Roberto
   Jesus Alonso, Maria
   Antonio Uranga, Jose
   Lopez-Miranda, Visitacion
   Miguel, Marta
TI Egg white hydrolysates improve vascular damage in obese Zucker rats by
   its antioxidant properties
SO JOURNAL OF FOOD BIOCHEMISTRY
LA English
DT Article
DE cardiovascular diseases; egg white proteins; enzymatic hydrolysis;
   metabolic syndrome; Zucker rats
ID I-CONVERTING-ENZYME; OXIDATIVE STRESS; ENDOTHELIAL DYSFUNCTION;
   RESISTANCE ARTERIES; BIOACTIVE PEPTIDES; CORONARY-ARTERIES;
   BLOOD-PRESSURE; ANGIOTENSIN; HYPERTENSION; INFLAMMATION
AB Metabolic Syndrome (MS) is related to increased risk of early death due to cardiovascular complications, among others. Dietary intervention has been suggested as the safest and most cost-effective alternative for treatment of those alterations in patients with MS. The aim of this study was to investigate the effects of different egg white hydrolysates (HEW1 and HEW2) in obese Zucker rats, focus on the development of cardiovascular complications. Blood pressure, heart rate, basal cardiac function and vascular reactivity in aorta and mesenteric resistance arteries were evaluated. Reactive oxygen species production by dihydroethidium-emitted fluorescence, NOX-1 mRNA levels by qRT-PCR, angiotensin-converting enzyme activity by fluorimetry and kidney histopathology were also analysed. Both hydrolysates improve the endothelial dysfunction occurring in resistance arteries. Additionally, HEW2 reduced vascular oxidative stress. Practical applications Egg white is a good source of bioactive peptides, some of them with high antioxidant activity. They may be used as functional foods ingredients and could serve as an alternative therapeutic option to decrease some Metabolic Syndrome-related complications. This study suggests that these hydrolysates could be an interesting non-pharmacological tool to control cardiovascular complications related to Metabolic Syndrome.
C1 [Garces-Rimon, Marta; Miguel, Marta] UAM, CSIC, CIAL, Inst Invest Ciencias Alimentac, Madrid, Spain.
   [Garces-Rimon, Marta; Gonzalez, Cristina; Herradon, Esperanza; Antonio Uranga, Jose; Lopez-Miranda, Visitacion; Miguel, Marta] CSIC, Inst Invest Ciencias Alimentac, Unidad Asociada I D I, Grp Invest Nutr & Farmacol URJC, Madrid, Spain.
   [Gonzalez, Cristina; Hernanz, Raquel; Herradon, Esperanza; Martin, Angela; Palacios, Roberto; Jesus Alonso, Maria; Antonio Uranga, Jose; Lopez-Miranda, Visitacion] Univ Rey Juan Carlos, Fac Ciencias Salud, Dept Ciencias Basicas Salud, Madrid, Spain.
   [Garces-Rimon, Marta] Univ Francisco Vitoria, Inst Invest Biosanitarias, Grp Biotecnol Alimentaria, Madrid, Spain.
C3 Consejo Superior de Investigaciones Cientificas (CSIC); CSIC-UAM -
   Instituto de Investigacion en Ciencias de la Alimentacion (CIAL);
   Autonomous University of Madrid; Consejo Superior de Investigaciones
   Cientificas (CSIC); CSIC-UAM - Instituto de Investigacion en Ciencias de
   la Alimentacion (CIAL); Universidad Rey Juan Carlos; Universidad
   Francisco de Vitoria
RP Garcés-Rimón, M (corresponding author), UAM, CSIC, CIAL, Inst Invest Ciencias Alimentac, Madrid, Spain.; Garcés-Rimón, M (corresponding author), Univ Francisco Vitoria, Inst Invest Biosanitarias, Grp Biotecnol Alimentaria, Madrid, Spain.
EM m.garces.rimon@gmail.com
RI Alonso, María/AAB-4309-2019; Pliego, Esperanza/AAB-5084-2019; Martin,
   Angela/AAB-4185-2019; Garces-Rimon, Marta/AAD-3050-2021; HERNANZ,
   RAQUEL/H-8943-2015; Palacios-Ramirez, Roberto/H-9905-2015;
   Lopez-Miranda, Visitacion/E-1116-2012; Uranga, Jose/M-4343-2018
OI Palacios-Ramirez, Roberto/0000-0002-0867-1277; Gonzalez Fernandez,
   Cristina/0000-0003-1232-9922; Hernanz, Raquel/0000-0002-2624-9387;
   Garces-Rimon, Marta/0000-0002-3888-4150; Martin Cortes,
   Angela/0000-0002-4368-6300; Alonso, Maria Jesus/0000-0003-4912-1121;
   Lopez-Miranda, Visitacion/0000-0003-1378-0387; Uranga,
   Jose/0000-0003-4656-8569; Herradon Pliego, Esperanza/0000-0001-7210-6283
FU Ministerio de Ciencia, Innovacion y Universidades [AGL2012-32387,
   SAF2015-69294-R]
FX Ministerio de Ciencia, Innovacion y Universidades, Grant/Award Number:
   AGL2012-32387 and SAF2015-69294-R
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NR 54
TC 7
Z9 7
U1 2
U2 22
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0145-8884
EI 1745-4514
J9 J FOOD BIOCHEM
JI J. Food Biochem.
PD DEC
PY 2019
VL 43
IS 12
AR e13062
DI 10.1111/jfbc.13062
EA OCT 2019
PG 14
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA LB1IL
UT WOS:000488335700001
PM 31571257
OA gold
DA 2025-06-11
ER

PT J
AU Egan, KJ
   von Schantz, M
   Negrao, AB
   Santos, HC
   Horimoto, ARVR
   Duarte, NE
   Gonçalves, GC
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   Vallada, H
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   Azambuja, AP
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   Alvim, RO
   Krieger, JE
   Pereira, AC
AF Egan, Kieren J.
   von Schantz, Malcolm
   Negrao, Andre B.
   Santos, Hadassa C.
   Horimoto, Andrea R. V. R.
   Duarte, Nubia E.
   Goncalves, Guilherme C.
   Soler, Julia M. P.
   de Andrade, Mariza
   Lorenzi-Filho, Geraldo
   Vallada, Homero
   Taporoski, Tamara P.
   Pedrazzoli, Mario
   Azambuja, Ana P.
   de Oliveira, Camila M.
   Alvim, Rafael O.
   Krieger, Jose E.
   Pereira, Alexandre C.
TI Cohort profile: the Baependi Heart Study - a family-based, highly
   admixed cohort study in a rural Brazilian town
SO BMJ OPEN
LA English
DT Article
ID CARDIOVASCULAR RISK-FACTORS; AGE-AT-ONSET; METABOLIC SYNDROME;
   GENETIC-ANALYSIS; HERITABILITY; HEALTH; POPULATION; PHENOTYPES;
   ADMIXTURE; ANCESTRY
AB Purpose: Cardiovascular disease (CVD) is a major challenge to global health. The same epidemiological transition scenario is replayed as countries develop, but with variations based on environment, culture and ethnic mixture. The Baependi Heart Study was set up in 2005 to develop a longitudinal family-based cohort study that reflects on some of the genetic and lifestyle-related peculiarities of the Brazilian populations, in order to evaluate genetic and environmental influences on CVD risk factor traits.
   Participants: Probands were recruited in Baependi, a small rural town in the state of Minas Gerais, Brazil, following by first-degree and then increasingly more distant relatives. The first follow-up wave took place in 2010, and the second in 2016. At baseline, the study evaluated 1691 individuals across 95 families. Cross-sectional data have been collected for 2239 participants.
   Findings to date: Environmental and lifestyle factors and measures relevant to cardiovascular health have been reported. Having expanded beyond cardiovascular health outcomes, the phenotype datasets now include genetics, biochemistry, anthropometry, mental health, sleep and circadian rhythms. Many of these have yielded heritability estimates, and a shared genetic background of anxiety and depression has recently been published. In spite of universal access to electricity, the population has been found to be strongly shifted towards morningness compared with metropolitan areas.
   Future plans: A new follow-up, marking 10 years of the study, is ongoing in 2016, in which data are collected as in 2010 (with the exception of the neuropsychiatric protocol). In addition to this, a novel questionnaire package collecting information about intelligence, personality and spirituality is being planned. The data set on circadian rhythms and sleep will be amended through additional questionnaires, actimetry, home sleep EEG recording and dim light melatonin onset (DLMO) analysis. Finally, the anthropometric measures will be expanded by adding three-dimensional facial photography, voice recording and anatomical brain MRI.
C1 [Egan, Kieren J.; von Schantz, Malcolm] Univ Surrey, Fac Hlth & Med Sci, Guildford, Surrey, England.
   [von Schantz, Malcolm; Negrao, Andre B.; Santos, Hadassa C.; Horimoto, Andrea R. V. R.; Duarte, Nubia E.; Goncalves, Guilherme C.; de Oliveira, Camila M.; Krieger, Jose E.; Pereira, Alexandre C.] Univ Sao Paulo, Sch Med, Heart Inst Incor, Lab Genet & Mol Cardiol, Sao Paulo, Brazil.
   [von Schantz, Malcolm; Vallada, Homero; Taporoski, Tamara P.] Univ Sao Paulo, Sch Med, Inst Psychiat, Sao Paulo, Brazil.
   [Soler, Julia M. P.] Univ Sao Paulo, Dept Stat, Sao Paulo, Brazil.
   [de Andrade, Mariza] Mayo Clin, Dept Hlth Sci Res, Rochester, MN USA.
   [Lorenzi-Filho, Geraldo] Univ Sao Paulo, Sch Med, Sleep Lab, Div Pulm,Heart Inst Incor, Sao Paulo, Brazil.
   [Pedrazzoli, Mario] Univ Sao Paulo, Sch Arts Sci & Humanities, Sao Paulo, Brazil.
   [Azambuja, Ana P.] Natura Innovat & Prod Technol Ltd, Cajamar, SP, Brazil.
   [de Oliveira, Camila M.; Alvim, Rafael O.] Univ Fed Juiz de Fora, Dept Physiol, Juiz De Fora, Brazil.
C3 University of Surrey; Universidade de Sao Paulo; Universidade de Sao
   Paulo; Universidade de Sao Paulo; Mayo Clinic; Universidade de Sao
   Paulo; Universidade de Sao Paulo; Universidade Federal de Juiz de Fora
RP von Schantz, M (corresponding author), Univ Surrey, Fac Hlth & Med Sci, Guildford, Surrey, England.; von Schantz, M (corresponding author), Univ Sao Paulo, Sch Med, Heart Inst Incor, Lab Genet & Mol Cardiol, Sao Paulo, Brazil.; von Schantz, M (corresponding author), Univ Sao Paulo, Sch Med, Inst Psychiat, Sao Paulo, Brazil.
EM m.von.schantz@surrey.ac.uk; alexandre.pereira@incor.usp.br
RI Pereira, Claudia/AAZ-9123-2021; NegrÃ£o, AndrÃ©/C-9526-2014; Alvim,
   Rafael/ABA-7823-2021; Krieger, Jose E/C-3117-2011; Soler,
   Julia/J-3002-2017; Lorenzi-Filho, Geraldo/E-1062-2012; Pedrazzoli,
   Mario/B-3757-2013; Vallada, Homero/D-1333-2014; von Schantz,
   Malcolm/C-5962-2014
OI Krieger, Jose E/0000-0001-5464-1792; Soler, Julia/0000-0002-0179-8574;
   Egan, Kieren/0000-0002-1639-4281; de Andrade,
   Mariza/0000-0003-2329-2686; Lorenzi-Filho, Geraldo/0000-0002-7011-7373;
   Pedrazzoli, Mario/0000-0002-5257-591X; Azambuja,
   Ana/0000-0002-3667-5689; Vallada, Homero/0000-0001-5123-8295; von
   Schantz, Malcolm/0000-0002-9911-9436
FU FAPESP [2007/58150-7, 2010/51010-8, 2011/05804-5, 2013/17368-0]; CNPq
   [150653/2008-5, 481304/2012-6, 400791/2015-5]; Fundacao Zerbini;
   Hospital Samaritano; Global Innovation Initiative - British Council;
   Global Innovation Initiative - UK Department of Business and Skills;
   Swedish Research Council [2011-05804] Funding Source: Swedish Research
   Council
FX This study was supported by awards from FAPESP to ACP, JEK, ARVRH and MP
   (grants 2007/58150-7, 2010/51010-8, 2011/05804-5, 2013/17368-0), from
   CNPq to ACP, JEK, HV, ARVRH and MvS (150653/2008-5, 481304/2012-6, and
   400791/2015-5), Fundacao Zerbini and Hospital Samaritano, and by the
   Global Innovation Initiative to MvS (jointly funded by the British
   Council and the UK Department of Business and Skills).
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NR 42
TC 32
Z9 33
U1 0
U2 14
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2044-6055
J9 BMJ OPEN
JI BMJ Open
PY 2016
VL 6
IS 10
AR e011598
DI 10.1136/bmjopen-2016-011598
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA EG8JO
UT WOS:000391303200036
PM 27797990
OA Green Published, gold, Green Accepted
DA 2025-06-11
ER

PT J
AU Andrade, N
   Peixoto, JAB
   Oliveira, MBPP
   Martel, F
   Alves, RC
AF Andrade, Nelson
   Peixoto, Juliana A. Barreto
   Oliveira, M. Beatriz P. P.
   Martel, Fatima
   Alves, Rita C.
TI Can coffee silverskin be a useful tool to fight metabolic syndrome?
SO FRONTIERS IN NUTRITION
LA English
DT Review
DE coffee by-products; caffeine; chlorogenic acids; melanoidins; metabolic
   syndrome
ID COMMERCIAL HYPOGLYCEMIC DRUGS; CHLOROGENIC ACID; OXIDATIVE STRESS;
   HEALTH-BENEFITS; FERULIC ACID; BIOACTIVE COMPOUNDS; CAFFEINE INTAKE; GUT
   MICROBIOTA; GLUCOSE-UPTAKE; CONSUMPTION
AB Coffee is one of the most consumed products in the world, and its by-products are mainly discarded as waste. In order to solve this problem and in the context of a sustainable industrial attitude, coffee by-products have been studied concerning their chemical and nutritional features for a potential application in foodstuffs or dietary supplements. Under this perspective, coffee silverskin, the main by-product of coffee roasting, stands out as a noteworthy source of nutrients and remarkable bioactive compounds, such as chlorogenic acids, caffeine, and melanoidins, among others. Such compounds have been demonstrating beneficial health properties in the context of metabolic disorders. This mini-review compiles and discusses the potential health benefits of coffee silverskin and its main bioactive components on metabolic syndrome, highlighting the main biochemical mechanisms involved, namely their effects upon intestinal sugar uptake, glucose and lipids metabolism, oxidative stress, and gut microbiota. Even though additional research on this coffee by-product is needed, silverskin can be highlighted as an interesting source of compounds that could be used in the prevention or co-treatment of metabolic syndrome. Simultaneously, the valorization of this by-product also responds to the sustainability and circular economy needs of the coffee chain.
C1 [Andrade, Nelson; Peixoto, Juliana A. Barreto; Oliveira, M. Beatriz P. P.; Alves, Rita C.] Univ Porto, Fac Pharm, Dept Chem Sci, REQUIMTE LAQV, Porto, Portugal.
   [Andrade, Nelson; Martel, Fatima] Univ Porto, Fac Med Porto, Dept Biomed, Unit Biochem, Porto, Portugal.
   [Martel, Fatima] Univ Porto, Inst Invest & Inovacao Saude I3S, Porto, Portugal.
C3 Universidade do Porto; Universidade do Porto; Universidade do Porto; i3S
   - Instituto de Investigacao e Inovacao em Saude, Universidade do Porto
RP Andrade, N; Alves, RC (corresponding author), Univ Porto, Fac Pharm, Dept Chem Sci, REQUIMTE LAQV, Porto, Portugal.; Andrade, N (corresponding author), Univ Porto, Fac Med Porto, Dept Biomed, Unit Biochem, Porto, Portugal.
EM nelsonandrade@outlook.com; rcalves@ff.up.pt
RI Andrade, Nelson/AAK-3763-2021; Alves, Rita/I-9081-2012; Peixoto,
   Juliana/JWO-1848-2024; Oliveira, Beatriz/KGL-8895-2024; Martel,
   Felix/JFJ-0587-2023; Oliveira, Beatriz/D-9025-2013
OI Barreto Peixoto, Juliana Alexandra/0000-0002-1853-1622; Andrade,
   Nelson/0000-0003-2600-8599; Martel, Fatima/0000-0002-0525-3416;
   Oliveira, Beatriz/0000-0002-6767-6596
FU AgriFood XXI I&D&I project - European Regional Development Fund (ERDF)
   through the NORTE 2020 (Programa Operacional Regional do Norte
   2014/2020) [NORTE-01-0145-FEDER-000041]
FX The open access publication fee of this paper was funded by AgriFood XXI
   I & D & I project (NORTE-01-0145-FEDER-000041) cofinanced by European
   Regional Development Fund (ERDF) through the NORTE 2020 (Programa
   Operacional Regional do Norte 2014/2020).
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NR 87
TC 4
Z9 4
U1 4
U2 17
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD SEP 21
PY 2022
VL 9
AR 966734
DI 10.3389/fnut.2022.966734
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 6Q6PV
UT WOS:000891735300001
PM 36211502
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Korman, NH
   Shah, S
   Suetani, S
   Kendall, K
   Rosenbaum, S
   Dark, F
   Nadareishvili, K
   Siskind, D
AF Korman, Nicole H.
   Shah, Shelukumar
   Suetani, Shuichi
   Kendall, Karen
   Rosenbaum, Simon
   Dark, Frances
   Nadareishvili, Ketevan
   Siskind, Dan
TI Evaluating the Feasibility of a Pilot Exercise Intervention Implemented
   Within a Residential Rehabilitation Unit for People With Severe Mental
   Illness: GO HEART: (Group Occupational Health Exercise and
   Rehabilitation Treatment)
SO FRONTIERS IN PSYCHIATRY
LA English
DT Article
DE severe mental illness; exercise; rehabilitation; pilot study; exercise
   physiology; mental health
ID QUALITY-OF-LIFE; PHYSICAL-ACTIVITY; CARDIORESPIRATORY FITNESS;
   AUTONOMOUS MOTIVATION; CHRONIC-SCHIZOPHRENIA; CARDIOMETABOLIC RISK;
   GENERAL-POPULATION; PSYCHOTIC ILLNESS; NEGATIVE SYMPTOMS; WALK TEST
AB Purpose: People with severe mental illness are sedentary, have high cardio-metabolic risks and significantly reduced life expectancy. Despite considerable data regarding positive physical and mental health outcomes following exercise interventions, implementation and evaluation of real-world programs is lacking. The primary aim of this study was to assess the feasibility of an exercise intervention implemented by exercise physiology (EP) students within a residential rehabilitation unit for residents with severe mental illness, together with assessment of a range of secondary physical and mental health outcomes pre-and post-the intervention.
   Design: Single arm, prospective pilot study evaluating outcomes pre-and post-a 10 week intervention.
   Method: Inactive people with severe mental illness participated in a mixed aerobic and resistance exercise intervention, three times per week for 10 weeks. Data was obtained from a sample of 16 residents with severe mental illness; primary diagnosis schizophrenia (n = 12). Primary outcomes were feasibility as assessed using recruitment, retention and participation rates, as well as reasons for withdrawal and amount of exercise achieved. Secondary outcomes included: functional exercise capacity was measured by the 6-min walk test; metabolic data obtained from anthropometric measurements; blood pressure; fasting cholesterol and blood sugar levels; and physical activity levels and mental health as assessed by self-administered questionnaires measured before and after the intervention.
   Results: Broad level acceptance of the program: high recruitment (81%), retention (77%), and participation (78%) rates were observed. Promising improvements in functional exercise capacity, volume of exercise, and negative symptoms was demonstrated in those who completed.
   Conclusions: Exercise interventions delivered by EP students in a residential rehabilitation setting for people with SMI are feasible; group setting, supervision and choice for engagement are important considerations. Evaluation of longitudinal, multi site studies, with the addition of dietary interventions within residential rehabilitation units are warranted. Addressing cost feasibility and cost effectiveness of such programs is recommended.
C1 [Korman, Nicole H.; Shah, Shelukumar; Suetani, Shuichi; Dark, Frances; Nadareishvili, Ketevan; Siskind, Dan] Metro South Hlth Serv, Addict Serv, Brisbane, Qld, Australia.
   [Korman, Nicole H.; Shah, Shelukumar; Suetani, Shuichi; Dark, Frances; Nadareishvili, Ketevan; Siskind, Dan] Metro South Hlth Serv, Mental Hlth Serv, Brisbane, Qld, Australia.
   [Korman, Nicole H.; Suetani, Shuichi; Dark, Frances; Siskind, Dan] Univ Queensland, Sch Med, Brisbane, Qld, Australia.
   [Kendall, Karen] Queensland Univ Technol, Sch Exercise & Nutr Sci, Brisbane, Qld, Australia.
   [Rosenbaum, Simon] Univ New South Wales, Sch Psychiat, Sydney, NSW, Australia.
C3 University of Queensland; Queensland University of Technology (QUT);
   University of New South Wales Sydney
RP Korman, NH (corresponding author), Metro South Hlth Serv, Addict Serv, Brisbane, Qld, Australia.; Korman, NH (corresponding author), Metro South Hlth Serv, Mental Hlth Serv, Brisbane, Qld, Australia.; Korman, NH (corresponding author), Univ Queensland, Sch Med, Brisbane, Qld, Australia.
EM n.korman@uq.edu.au
RI Rosenbaum, Simon/Y-3241-2019; Siskind, Dan/A-9812-2014
OI Suetani, Shuichi/0000-0002-2487-5691; Siskind, Dan/0000-0002-2072-9216;
   Rosenbaum, Simon/0000-0002-8984-4941
FU NHMRC ECF [APP1111136]
FX DS is supported in part by an NHMRC ECF APP1111136.
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   World Health Organization, 2010, GLOB REC PHYS ACT HL
NR 72
TC 14
Z9 15
U1 0
U2 10
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-0640
J9 FRONT PSYCHIATRY
JI Front. Psychiatry
PD JUL 27
PY 2018
VL 9
AR 343
DI 10.3389/fpsyt.2018.00343
PG 11
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA GO4TT
UT WOS:000440009000002
PM 30100885
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Bensassi, I
   Lopez-Castroman, J
   Maller, JJ
   Meslin, C
   Wyart, M
   Ritchie, K
   Courtet, P
   Artero, S
   Calti, R
AF Bensassi, Ismail
   Lopez-Castroman, Jorge
   Maller, Jerome J.
   Meslin, Chantal
   Wyart, Marilyn
   Ritchie, Karen
   Courtet, Philippe
   Artero, Sylvaine
   Calti, Raffaella
TI Smaller hippocampal volume in current but not in past depression in
   comparison to healthy controls: Minor evidence from an older adults
   sample
SO JOURNAL OF PSYCHIATRIC RESEARCH
LA English
DT Article
DE Depression; Neuroimaging; Brain imaging/neuroimaging; Biological
   markers; Mood disorders
ID AUTOMATED METHODS FREESURFER; SURFACE-BASED ANALYSIS; LATE-LIFE
   DEPRESSION; ANTERIOR CINGULATE; MAJOR DEPRESSION; LATE-ONSET; METABOLIC
   SYNDROME; BRAIN MORPHOLOGY; STRESS SYSTEM; MATTER VOLUME
AB Background: Structural neuroimaging studies revealed a consistent pattern of volumetric reductions in both hippocampus (HC) and anterior cingulate cortex (ACC) of individuals with major depressive episode(s) (MDE). This study investigated HC and ACC volume differences in currently depressed individuals (n = 150), individuals with a past lifetime MDE history (n = 79) and healthy controls (n = 287).
   Methods: Non-demented individuals were recruited from a cohort of community-dwelling older adults (ESPRIT study). T1-weighted magnetic resonance images and FreeSurfer Software (automated method) were used. Concerning HC, a manual method of measurement dividing HC into head, body, and tail was also used. General Linear Model was applied adjusting for covariates.
   Results: Current depression was associated with lower left posterior HC volume, using manual measurement, in comparison to healthy status. However, when we slightly changed sub-group inclusion criteria, results did not survive to correction for multiple comparisons.
   Conclusions: The finding of lower left posterior HC volume in currently depressed individuals but not in those with a past MDE compared to healthy controls could be related to brain neuroplasticity. Additionally, our results may suggest manual measures to be more sensitive than automated methods.
C1 [Bensassi, Ismail; Lopez-Castroman, Jorge; Maller, Jerome J.; Meslin, Chantal; Wyart, Marilyn; Ritchie, Karen; Courtet, Philippe; Artero, Sylvaine; Calti, Raffaella] Univ Montpellier, INSERM, Neuropsychiat Epidemiol & Clin Res, 39 Ave Charles Flahault, F-34093 Montpellier 5, France.
   [Wyart, Marilyn] CHRU Nimes, Dept Adult Psychiat, Nimes, France.
   [Maller, Jerome J.] The Alfred, Monash Alfred Psychiat Res Ctr, Melbourne, Vic, Australia.
   [Maller, Jerome J.] Monash Univ, Cent Clin Sch, Melbourne, Vic, Australia.
   [Maller, Jerome J.] Gen Elect Healthcare, Melbourne, Vic, Australia.
   [Meslin, Chantal] Australian Natl Univ, Ctr Mental Hlth Res, Canberra, ACT, Australia.
   Univ Edinburgh, Fac Med, Ctr Clin Brain Sci, Edinburgh, Midlothian, Scotland.
   [Courtet, Philippe] CHU Montpellier, Lapeyronie Hosp, Dept Psychiat Emergency & Acute Care, Montpellier, France.
   [Courtet, Philippe; Calti, Raffaella] FondaMental Fdn, Creteil, France.
C3 Institut National de la Sante et de la Recherche Medicale (Inserm);
   Universite de Montpellier; Universite de Montpellier; CHU de Nimes;
   Monash University; Monash University; General Electric; Australian
   National University; University of Edinburgh; Universite de Montpellier;
   CHU de Montpellier
RP Calti, R (corresponding author), Univ Montpellier, INSERM, Neuropsychiat Epidemiol & Clin Res, 39 Ave Charles Flahault, F-34093 Montpellier 5, France.
EM raffaella.calati@gmail.com
RI Lopez-Castroman, Jorge/A-6192-2014; Artero, Sylvaine/AAE-6059-2020;
   Calati, Raffaella/J-9931-2018; Maller, Jerome/H-4963-2014; Ritchie,
   Karen/G-3571-2013
OI Maller, Jerome/0000-0003-4685-1508; Courtet,
   Philippe/0000-0002-6519-8586; Artero, Sylvaine/0000-0002-1671-226X;
   Ritchie, Karen/0000-0002-0688-8982
FU FondaMental Foundation, Creteil, France; Servier
FX Dr. Ismail Bensassi, Jorge Lopez-Castroman, Jerome J Maller, Chantal
   Meslin, Marilyn Wyart, Karen Ritchie, and Sylvaine Artero have no
   conflicts of interest to declare. Dr. Raffaella Galati received a grant
   from FondaMental Foundation, Creteil, France (2015-2016). Prof. Philippe
   Courtet received research grants from Servier, and fees for
   presentations at congresses or participation in scientific boards from
   Janssen, Lundbeck, Otsuka, Servier.
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NR 90
TC 3
Z9 3
U1 0
U2 17
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-3956
EI 1879-1379
J9 J PSYCHIATR RES
JI J. Psychiatr. Res.
PD JUL
PY 2018
VL 102
BP 159
EP 167
DI 10.1016/j.jpsychires.2018.04.008
PG 9
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA GN0LS
UT WOS:000438660500024
PM 29665490
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Gallego, MPO
   López, PB
   Armero, MAT
   Alemán, JA
   Albero, JS
   López, PJT
AF Orgaz Gallego, Maria Pilar
   Bermejo Lopez, Pablo
   Tricio Armero, Miguel Angel
   Abellan Aleman, Jose
   Solera Albero, Juan
   Tarraga Lopez, Pedro Juan
TI Metabolic syndrome and its components in Spanish postmenopausal women
SO NUTRICION HOSPITALARIA
LA English
DT Article
DE Metabolic syndrome; Postmenopause; Insulin resistance; Cardiovascular
   risk
ID CARDIOVASCULAR RISK-FACTORS; BLOOD-PRESSURE; PREVALENCE; OBESITY;
   POPULATION; DISEASE; HYPERTENSION; MORTALITY; EFFICACY; SPAIN
AB Objectives: this study aimed to estimate prevalence of metabolic syndrome and all its components to know the cardiovascular risk and metabolic control of the main risk factors in postmenopausal women aged over 45 years in the province of Cuenca (Castilla-La Mancha, Spain).
   Methods: in this cross-sectional study, we randomly selected 716 postmenopausal women from 3,108 women aged over 45. Metabolic syndrome was identified according to the National Cholesterol Education Program Adult Treatment Panel HI definition. Cardiovascular risk was calculated by the Systematic Coronary Risk Evaluation (<65 years). The American Diabetes Association's standards of medical care in diabetes were used to estimate metabolic control. The statistical analysis was done with SPPS.19
   Results: prevalence of metabolic syndrome was 61.7% (95%CI: 56.9-66.4). Prevalence of each component was: high blood pressure: 95.8% (95%CI: 95.7-95.8), abdominal obesity: 91% (95%CI: 90.9-91.0), low high-density lipoproteins cholesterol (HDLc) levels: 70% (95%CI: 69.8-69.9), high triglyceride levels: 56.9% (95%CI: 56.4-56.9), high glucose levels: 54.3% (95%CI: 54.2-54.3). Cardiovascular risk was moderate until 65 years, but was high after this age. Metabolic control in postmenopausal women was very good for glucose, bad for systolic blood pressure and worse for lipid levels. Bad blood pressure control was associated with being over 65 years, being hypertensive and taking treatment for diabetes, but it reduced when being physically limited to do moderate exercise and anxiety increased.
   Conclusions: prevalence of metabolic syndrome in postmenopausal women in the province of Cuenca is the highest in Spain. High blood pressure and abdominal obesity are the commonest components. Cardiovascular risk was moderate-high in postmenopausal women, but systolic blood pressure and lipid profile were unsatisfactorily controlled. Early intervention is necessary to achieve a better risk profile.
C1 [Orgaz Gallego, Maria Pilar] Especial Diag & Treatments Ctr Tarancon, Cuenca, Spain.
   [Tarraga Lopez, Pedro Juan] Univ Med Albacete, Dept Med, Albacete, Spain.
   [Bermejo Lopez, Pablo] Univ Castilla La Mancha, Comp Syst Dept, Ciudad Real, Spain.
   [Tricio Armero, Miguel Angel] Especial Diag & Treatments Ctr Tarancon, Cuenca, Spain.
   [Abellan Aleman, Jose] Catholic Univ San Antonio Murcia, Cathedra Cardiovasc Risk, Murcia, Spain.
C3 Universidad de Castilla-La Mancha; Universidad Catolica de Murcia
RP López, PJT (corresponding author), C Angel 53 1-E, Albacete 02002, Spain.
EM pjtarraga@sescam.jccm.es
RI Bermejo, Pablo/E-8455-2016
FU JCCM [PEII-2014-049-P]; MECD [TIN2013-46638-C3-3-P]
FX This work has been partially supported by the JCCM under regional
   project PEII-2014-049-P, and the MECD under national project
   TIN2013-46638-C3-3-P
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NR 54
TC 10
Z9 11
U1 0
U2 11
PU ARAN EDICIONES, S L
PI MADRID
PA C/ CASTELLO, 128, 1O, MADRID, 28006, SPAIN
SN 0212-1611
EI 1699-5198
J9 NUTR HOSP
JI Nutr. Hosp.
PD AUG
PY 2015
VL 32
IS 2
BP 656
EP 666
DI 10.3305/nh.2015.32.2.9211
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA CO3BH
UT WOS:000359031000024
PM 26268096
DA 2025-06-11
ER

PT J
AU Jani, BD
   Cavanagh, J
   Barry, SJE
   Der, G
   Sattar, N
   Mair, FS
AF Jani, Bhautesh Dinesh
   Cavanagh, Jonathan
   Barry, Sarah J. E.
   Der, Geoff
   Sattar, Naveed
   Mair, Frances S.
TI Revisiting the J shaped curve, exploring the association between
   cardiovascular risk factors and concurrent depressive symptoms in
   patients with cardiometabolic disease: Findings from a large
   cross-sectional study
SO BMC CARDIOVASCULAR DISORDERS
LA English
DT Article
DE Cardiovascular risk factors; J-curve; Depression; Blood pressure; Body
   mass index; Total cholesterol; HbA1C; Diabetes; Stroke; Coronary heart
   disease
ID CORONARY-HEART-DISEASE; LOW BLOOD-PRESSURE; MYOCARDIAL-INFARCTION;
   SERUM-CHOLESTEROL; GENERAL-POPULATION; MAJOR DEPRESSION; NEGATIVE
   AFFECT; ARTERY-DISEASE; HEALTH SURVEYS; LIPID-LEVELS
AB Background: Depression is common in patients with cardiometabolic diseases but little is known about the relationship, if any, between cardiovascular risk factor values and depressive symptoms in patients with these conditions. The objective of this paper is to study the association between cardiovascular risk factors and concurrent depressive symptoms in patients with three common cardiometabolic conditions: coronary heart disease (CHD), stroke and diabetes.
   Methods: We retrospectively reviewed primary care data for N = 35537 with 1 of the above 3 conditions who underwent depression screening using the depressive subscale of hospital anxiety and depression score (HADS-D). We reviewed 4 cardiometabolic risk factors (Systolic Blood Pressure [SBP], Diastolic Blood Pressure [DBP], BMI and total cholesterol) recorded concurrently in all patients and HbA1c in patients with diabetes (n = 18453). We analysed the association between individual risk factor value and a positive HADS-D screening result (>7) using logistic regression.
   Results: SBP and BMI were noted to have a non-linear "J-shaped" relationship with the probability of having a positive HADS-D and observed nadirs (levels with the lowest probability) of 148 mm Hg and 30.70 kg/m2, respectively. Total cholesterol and DBP found to have a weaker curvilinear association with concurrent depression symptoms and nadirs of 3.60 mmol/l and 74 mmHg. Among patients with Diabetes, HbA1c was also found to have a " J-shaped" relationship with probability of having a positive HADS-D with an observed nadir of 7.06% DCCT. The above relationships remain significant after adjusting for age, sex, socio-economic status and number of co-morbid conditions.
   Conclusion: In patients with cardiometabolic disease, cardiovascular risk factor values at both extremes were associated with higher positive depression screening after adjusting for confounders. These findings have potentially important implications for clinical practice in relation to both risk stratification for depression and approaches to secondary prevention in individuals with cardiometabolic disease and merit further investigation to determine the nature and direction of the observed association.
C1 [Jani, Bhautesh Dinesh; Mair, Frances S.] Univ Glasgow, Coll Med Vet & Life Sci, Inst Hlth & Wellbeing, Glasgow G112 9LX, Lanark, Scotland.
   [Cavanagh, Jonathan] Univ Glasgow, So Gen Hosp, Coll Med Vet & Life Sci, Sackler Inst,Inst Hlth & Wellbeing, Glasgow G51 4TF, Lanark, Scotland.
   [Barry, Sarah J. E.] Univ Glasgow, Coll Med Vet & Life Sci, Inst Hlth & Well Being, Robertson Ctr Biostat, Glasgow G12 8QQ, Lanark, Scotland.
   [Der, Geoff] Univ Glasgow, Coll Med Vet & Life Sci, Inst Hlth & Wellbeing, MRC CSO Social & Publ Hlth Sci Unit, Glasgow G12 8RZ, Lanark, Scotland.
   [Sattar, Naveed] Univ Glasgow, Coll Med Vet & Life Sci, Inst Cardiovasc & Med Sci, BHF Glasgow Cardiovasc Res Ctr, Glasgow G12 8TA, Lanark, Scotland.
C3 University of Glasgow; University of Glasgow; University of Glasgow;
   University of Glasgow; MRC/CSO SOCIAL AND PUBLIC HEALTH SCIENCES UNIT;
   University of Glasgow
RP Mair, FS (corresponding author), Univ Glasgow, Coll Med Vet & Life Sci, Inst Hlth & Wellbeing, Glasgow G112 9LX, Lanark, Scotland.
EM frances.mair@glasgow.ac.uk
RI Sattar, Naveed/AFN-0504-2022; Mair, Frances S/JNT-6073-2023
OI Mair, Frances S/0000-0001-9780-1135; Barry, Sarah
   J.E./0000-0003-3039-8729; Der, Geoff/0000-0002-8677-073X
FU Chief Scientist Office, Scotland [CAF/12/04]; MRC [MC_UU_12017/5]
   Funding Source: UKRI
FX The study was funded by Chief Scientist Office, Scotland CAF/12/04. The
   funders had no role in study design, data collection and analysis,
   decision to publish, or preparation of the manuscript.
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NR 57
TC 8
Z9 10
U1 0
U2 2
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-2261
J9 BMC CARDIOVASC DISOR
JI BMC Cardiovasc. Disord.
PD OCT 28
PY 2014
VL 14
AR 139
DI 10.1186/1471-2261-14-139
PG 8
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA AY1HB
UT WOS:000347343400001
PM 25352020
OA Green Published, gold, Green Accepted
DA 2025-06-11
ER

PT J
AU Cai, M
   Li, SY
   Cai, KR
   Du, XL
   Han, J
   Hu, JY
AF Cai, Ming
   Li, Shuyao
   Cai, Keren
   Du, Xinlin
   Han, Jia
   Hu, Jingyun
TI Empowering mitochondrial metabolism: Exploring L-lactate supplementation
   as a promising therapeutic approach for metabolic syndrome
SO METABOLISM-CLINICAL AND EXPERIMENTAL
LA English
DT Article
DE Metabolic syndrome; L-lactate; Mitochondrial function; Mitochondrial
   metabolism
ID VASCULAR OXIDATIVE STRESS; SLC16 GENE FAMILY; MONOCARBOXYLATE
   TRANSPORTERS; INNER-MEMBRANE; INSULIN-RESISTANCE; EXTRACELLULAR LACTATE;
   LACTIC-DEHYDROGENASE; IMPAIRED AWARENESS; DIABETES-MELLITUS;
   ENERGY-METABOLISM
AB Mitochondrial dysfunction plays a critical role in the pathogenesis of metabolic syndrome (MetS), affecting various cell types and organs. In MetS animal models, mitochondria exhibit decreased quality control, characterized by abnormal morphological structure, impaired metabolic activity, reduced energy production, disrupted signaling cascades, and oxidative stress. The aberrant changes in mitochondrial function exacerbate the progression of metabolic syndrome, setting in motion a pernicious cycle. From this perspective, reversing mitochondrial dysfunction is likely to become a novel and powerful approach for treating MetS. Unfortunately, there are currently no effective drugs available in clinical practice to improve mitochondrial function. Recently, L-lactate has garnered significant attention as a valuable metabolite due to its ability to regulate mitochondrial metabolic processes and function. It is highly likely that treating MetS and its related complications can be achieved by correcting mitochondrial homeostasis disorders. In this review, we comprehensively discuss the complex relationship between mitochondrial function and MetS and the involvement of L-lactate in regulating mitochondrial metabolism and associated signaling pathways. Furthermore, it highlights recent findings on the involvement of L-lactate in common pathologies of MetS and explores its potential clinical application and further prospects, thus providing new insights into treatment possibilities for MetS
C1 [Cai, Ming; Li, Shuyao; Cai, Keren; Du, Xinlin; Han, Jia] Shanghai Univ Med & Hlth Sci, Coll Rehabil Sci, Shanghai 201318, Peoples R China.
   [Cai, Ming] Shanghai Jiao Tong Univ, Bio X Inst, Shanghai 200240, Peoples R China.
   [Hu, Jingyun] Shanghai Pudong New Area Peoples Hosp, Shanghai Key Lab Pathogen Fungi Med Testing, Cent Lab, Shanghai 201299, Peoples R China.
C3 Shanghai University of Medicine & Health Sciences; Shanghai Jiao Tong
   University
RP Han, J (corresponding author), Shanghai Univ Med & Hlth Sci, Coll Rehabil Sci, Shanghai 201318, Peoples R China.; Hu, JY (corresponding author), Shanghai Pudong New Area Peoples Hosp, Shanghai Key Lab Pathogen Fungi Med Testing, Cent Lab, Shanghai 201299, Peoples R China.
EM hanj_22@sumhs.edu.cn; hujingyun@shpdph.com
RI cai, ming/HPF-1404-2023; hu, jingyun/LBH-0381-2024; Cai,
   Ke/KDP-0078-2024
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NR 300
TC 2
Z9 2
U1 7
U2 18
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0026-0495
EI 1532-8600
J9 METABOLISM
JI Metab.-Clin. Exp.
PD MAR
PY 2024
VL 152
AR 155787
DI 10.1016/j.metabol.2024.155787
EA JAN 2024
PG 19
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA HJ7L6
UT WOS:001159197800001
PM 38215964
DA 2025-06-11
ER

PT J
AU Liang, J
   Gong, Y
   Wang, Y
   Qiu, QQ
   Zou, CY
   Dou, LJ
   Liu, XK
   Song, HD
AF Liang, Jun
   Gong, Ying
   Wang, Yu
   Qiu, QinQin
   Zou, Caiyan
   Dou, LianJun
   Liu, XueKui
   Song, Huaidong
TI Serum Gamma-Glutamyltransferase is Associated with Impaired Fasting
   Glucose in Chinese Adults: The Cardiometabolic Risk in Chinese (CRC)
   Study
SO CELL BIOCHEMISTRY AND BIOPHYSICS
LA English
DT Article
DE Serum gamma-glutamyltransferase; Impaired fasting glucose; Type 2
   diabetes; Triglyceride
ID TYPE-2 DIABETES-MELLITUS; FATTY LIVER-DISEASE; MIDDLE-AGED MEN;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; ALANINE AMINOTRANSFERASE;
   ENDOTHELIAL DYSFUNCTION; METABOLIC SYNDROME; WOMEN; GLUTAMYLTRANSFERASE
AB Recently, several studies found raised serum gamma-glutamyltransferase (GGT), and traditional marker of liver damage was associated with the risk of type 2 diabetes. The purpose of this study was to investigate the relationship between GGT and impaired fasting glucose (IFG), and evaluate the modification effects of age, BMI, prehypertension, and lipids in a large sample of Chinese adults. The study samples are from a community-based health examination survey in China. The sample for our analysis included 7,309 participants. IFG was defined as FBG from 6.1 to 7.0 mmol/L. Serum GGT, lipids, blood pressure, and glucose were measured. The odds ratios (ORs, 95 % CI) of IFG across increasing quintiles of GGT were 1.00, 0.91 (0.49-1.72), 1.27 (0.68-2.38), 2.31 (1.29-4.15), and 2.42 (1.32-4.42) (P for trend < 0.0001), adjusting for age, sex, BMI, blood pressure, glucose, and lipids. We found significant interactions between age, BMI, and GGT on IFG risk. When the joint effects were examined, we found an additional effect of triglycerides (TG) and GGT levels on IFG. Our data indicate that serum GGT concentration was associated with the risk of IFG, and the association was modified by TG level.
C1 [Liang, Jun; Gong, Ying; Zou, Caiyan; Dou, LianJun; Liu, XueKui] Southeast Univ, Xuzhou Cent Hosp, Xuzhou Inst Med Sci,Med Coll, Dept Endocrinol,Xuzhou Inst Diabet,Affiliated Hos, Xuzhou 221009, Jiangsu, Peoples R China.
   [Liang, Jun; Gong, Ying; Zou, Caiyan; Dou, LianJun; Liu, XueKui] Southeast Univ, Xuzhou Med Coll, Xuzhou Clin Sch, Affiliated Hosp,Med Sch, Xuzhou 221009, Jiangsu, Peoples R China.
   [Liang, Jun; Wang, Yu; Qiu, QinQin] Xuzhou Med Coll, Xuzhou 221009, Jiangsu, Peoples R China.
   [Song, Huaidong] Shanghai Jiao Tong Univ, Shanghai Inst Endocrinol, Sch Med, Shanghai 200025, Peoples R China.
C3 Southeast University - China; Southeast University - China; Xuzhou
   Medical University; Xuzhou Medical University; Shanghai Jiao Tong
   University
RP Liang, J (corresponding author), Southeast Univ, Xuzhou Cent Hosp, Xuzhou Inst Med Sci,Med Coll, Dept Endocrinol,Xuzhou Inst Diabet,Affiliated Hos, 199 South Jiefang Rd, Xuzhou 221009, Jiangsu, Peoples R China.
EM mwlj521@163.com
RI Gong, Ying/GLT-7555-2022; Song, Huai-Dong/G-8961-2011
FU Jiangsu Provincial Bureau of Health foundation [H201356]; International
   Exchange Program; Jiangsu Six Talent Peaks Program [2013-WSN-013];
   Xuzhou Outstanding Medical Academic Leader project; Xuzhou Science and
   Technology Grant [XM13B066]
FX Dr. Jun Liang's research was sponsored by Jiangsu Provincial Bureau of
   Health foundation (H201356) & International Exchange Program and Jiangsu
   Six Talent Peaks Program (2013-WSN-013), also supported by Xuzhou
   Outstanding Medical Academic Leader project and Xuzhou Science and
   Technology Grant (XM13B066). We thank all subjects for participating in
   this study.
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NR 26
TC 3
Z9 3
U1 1
U2 6
PU HUMANA PRESS INC
PI TOTOWA
PA 999 RIVERVIEW DRIVE SUITE 208, TOTOWA, NJ 07512 USA
SN 1085-9195
EI 1559-0283
J9 CELL BIOCHEM BIOPHYS
JI Cell Biochem. Biophys.
PD DEC
PY 2014
VL 70
IS 3
BP 1823
EP 1828
DI 10.1007/s12013-014-0136-9
PG 6
WC Biochemistry & Molecular Biology; Biophysics; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Cell Biology
GA AT2LT
UT WOS:000344767100051
PM 25030409
DA 2025-06-11
ER

PT J
AU Sankar, K
   Billah, AAM
   Shanmugasundram, N
   Veintramuthu, S
   Viswanathan, S
AF Sankar, Karthik
   Billah, Abdul Ajeed Mohathasim
   Shanmugasundram, Natrajan
   Veintramuthu, Sankar
   Viswanathan, Sushma
TI Effect of Vortioxetine in Comparison to Fluoxetine on Metabolic
   Parameters in Patients With Depressive Disorder: A Randomized Controlled
   Trial
SO CUREUS JOURNAL OF MEDICAL SCIENCE
LA English
DT Article
DE adverse drug reaction (adr); serotonin modulator; selective serotonin
   reuptake inhibitor (ssri); major depression disorder; metabolic syndrome
   (metsy)
ID DOUBLE-BLIND; SYNDROME ABNORMALITIES; LU AA21004; OPEN-LABEL; ANXIETY;
   TOLERABILITY; SYMPTOMS; EFFICACY; ADULTS; CARE
AB Background Major depressive disorder (MDD) is a debilitating mood disorder that increases the risk of metabolic syndrome (MS), emphasizing the need for mental and physical health treatments. Although many studies have linked atypical antipsychotics to metabolic disturbances, there is limited evidence linking selective serotonin reuptake inhibitor use to MS. This study aimed to assess the risk of MS among patients with MDD who were administered vortioxetine and fluoxetine. Methodology This was a prospective, open -label, randomized controlled trial conducted in the psychiatry department. Using computer -generated random numbers, the physician assigned fluoxetine 20 mg or vortioxetine 10 mg and recorded MS parameters at baseline and each visit (4, 8, 12, 16, 20, and 24 weeks). This study was registered with CTRI (CTRI/2021/07/034892). Results A total of 122 participants were allocated randomly to the following two groups: group A (n = 60) and group B (n = 62). An independent -sample t -test showed a significant improvement in fasting plasma glucose (FPG) at week eight (p = 0.005), triglycerides (TGs) at week 16 (p = 0.005), high -density lipoprotein (HDL) at week 20 (p = 0.005), and waist circumference at week 24 (p = 0.005) in group A compared to group B. However, systolic blood pressure (SBP) and diastolic blood pressure (DBP) were not significantly associated with either group (p = 0.126 and p = 0.793, respectively). Overall depression remission (Hamilton Depression Rating Scale (HAM -D)) and medication adherence rating scale scores were similar between groups (p = 0.337 and 0.325, respectively). Furthermore, most adverse drug reactions were possibly associated with the study drugs. Conclusions In comparison to group B, group A showed significant improvements in FPG, HDL, and waist circumference more effectively; however, both groups led to higher TG levels, with non -significant numerical improvements observed in SBP and DBP in both groups. In addition, both treatment groups reduced the HAM -D score and had a similar MDD remission rate.
C1 [Sankar, Karthik; Billah, Abdul Ajeed Mohathasim] Sri Ramachandra Inst Higher Educ & Res, Pharm, Chennai, India.
   [Shanmugasundram, Natrajan; Viswanathan, Sushma] Sri Ramachandra Inst Higher Educ & Res, Psychiat, Chennai, India.
   [Veintramuthu, Sankar] PSG Coll Pharm, Pharmaceut, Coimbatore, Tamil Nadu, India.
C3 Sri Ramachandra Institute of Higher Education & Research; Sri
   Ramachandra Institute of Higher Education & Research
RP Viswanathan, S (corresponding author), Sri Ramachandra Inst Higher Educ & Res, Psychiat, Chennai, India.
EM drsushma340@gmail.com
RI sankar, Dr. karthik/JXM-2262-2024; , A Mohathasim Billah/AGO-3034-2022
OI , A Mohathasim Billah/0000-0003-0552-0948
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NR 30
TC 0
Z9 0
U1 0
U2 0
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
EI 2168-8184
J9 CUREUS J MED SCIENCE
JI Cureus J Med Sci
PD JAN 29
PY 2024
VL 16
IS 1
AR e53178
DI 10.7759/cureus.53178
PG 9
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA IC2R2
UT WOS:001164063700014
PM 38420046
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Rocha, JA
   Allison, TG
   Santoalha, JM
   Araújo, V
   Pereira, FP
   Maciel, MJ
AF Rocha, Jose Afonso
   Allison, Thomas G.
   Santoalha, Jose Miguel
   Araujo, Vitor
   Pereira, Fernando Parada
   Maciel, Maria Julia
TI Musculoskeletal complaints in cardiac rehabilitation: Prevalence and
   impact on cardiovascular risk factor profile and functional and
   psychosocial status
SO REVISTA PORTUGUESA DE CARDIOLOGIA
LA English
DT Article
DE Coronary disease; Musculoskeletal pain; Physical activity
ID CORONARY-HEART-DISEASE; PHYSICAL-ACTIVITY; HOSPITAL ANXIETY; EXERCISE;
   DEPRESSION; HEALTH; COMORBIDITIES; QUESTIONNAIRE; FITNESS; ADULTS
AB Objective: To assess the prevalence of musculoskeletal complaints and their association with risk factor profile and functional and psychosocial status in patients on a cardiac rehabilitation program.
   Methods: In this cross-sectional study of 449 patients admitted within three months of an acute coronary syndrome, patients were divided into those with (MSC+) and those without (MSC-) musculoskeletal complaints. The Hospital Anxiety and Depression Scale and the Short Form 36 Health Survey were used to assess psychosocial status and quality of life, and the International Physical Activity Questionnaire for physical activity. Functional capacity was estimated from exercise testing.
   Results: Musculoskeletal pain was present in 119 patients (27%), mainly in the lower limbs (56%). MSC+ were older (mean 56.5 +/- 9.9 vs. 53.2 +/- 9.5 years; p<0.001) and more frequently women (20.2% vs. 9.1%; p<0.001). MSC+ had a higher prevalence of dyslipidemia (68.6% vs. 51.2%; p<0.001), hypertension (51.7% vs. 35.5%; p<0.001), obesity (29.4% vs. 17.9%; p<0.001) and metabolic syndrome (44.5% vs. 31.5%; p<0.001). MSC+ showed higher body mass index and waist circumference, and lower physical activity levels (p<0.05), as well as lower functional capacity (8.6 +/- 2.2 vs. 9.6 +/- 2.1 MET; p<0.05), higher scores for depression (6 [3-9] vs. 3 [1-7]; p<0.05) and anxiety (7 [3-10] vs. 5 [2-8]; p<0.05), and lower scores for physical (44.1 +/- 8.7 vs. 47.6 +/- 7.6; p<0.05) and mental (39.2 +/- 13.0 vs. 44.0 +/- 13.0; p<0.05) quality of life.
   Conclusions: Musculoskeletal complaints are common in cardiac rehabilitation and predict lower levels of physical activity, worse cardiovascular risk factor profile, and poorer functional capacity and psychosocial status, irrespective of age and gender. (C) 2014 Sociedade Portuguesa de Cardiologia. Published by Elsevier-Espana, S.L.U.-All rights reserved.
C1 [Rocha, Jose Afonso] Ctr Hosp Sao Joao, Oporto, Portugal.
   [Allison, Thomas G.] Mayo Clin, Dept Internal Med, Cardiovasc Dis, Rochester, MN USA.
   [Santoalha, Jose Miguel; Pereira, Fernando Parada] Ctr Hosp Sao Joao, Dept Phys, Rehabil Med, Oporto, Portugal.
   [Araujo, Vitor; Maciel, Maria Julia] Ctr Hosp Sao Joao, Dept Cardiol, Oporto, Portugal.
C3 Sao Joao Hospital; Mayo Clinic; Sao Joao Hospital; Sao Joao Hospital
RP Rocha, JA (corresponding author), Ctr Hosp Sao Joao, Oporto, Portugal.
EM afonsomrocha@gmail.com
RI Rocha, Afonso/AAK-9596-2021
OI ROCHA, J AFONSO/0000-0003-0824-4598; Maciel, Maria
   Julia/0000-0001-7623-467X
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NR 30
TC 7
Z9 7
U1 0
U2 5
PU ELSEVIER ESPANA SLU
PI BARCELONA
PA AV JOSEP TARRADELLAS, 20-30, 1ERA PLANTA, BARCELONA, CP-08029, SPAIN
SN 0870-2551
EI 0304-4750
J9 REV PORT CARDIOL
JI Rev. Port. Cardiol.
PD FEB
PY 2015
VL 34
IS 2
BP 117
EP 123
DI 10.1016/j.repc.2014.08.022
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA CC4NG
UT WOS:000350329500006
PM 25660461
OA gold
DA 2025-06-11
ER

PT J
AU Kalra, S
   Das, AK
   Baruah, MP
   Unnikrishnan, AG
   Dasgupta, A
   Shah, P
   Sahay, R
   Shukla, R
   Das, S
   Tiwaskar, M
   Vijayakumar, G
   Chawla, M
   Eliana, F
   Suastika, K
   Orabi, A
   Rahim, AAA
   Uloko, A
   Lamptey, R
   Ngugi, N
   Bahendeka, S
   Abdela, AA
   Mohammed, F
   Pathan, MF
   Rahman, MH
   Afsana, F
   Selim, S
   Moosa, M
   Murad, M
   Shreshtha, PK
   Shreshtha, D
   Giri, M
   Hussain, W
   Al-Ani, A
   Ramaiya, K
   Singh, S
   Raza, SA
   Aye, TT
   Garusinghe, C
   Muthukuda, D
   Weerakkody, M
   Kahandawa, S
   Bavuma, C
   Ruder, S
   Vanny, K
   Khanolkar, M
   Czupryniak, L
AF Kalra, Sanjay
   Das, A. K.
   Baruah, M. P.
   Unnikrishnan, A. G.
   Dasgupta, Arundhati
   Shah, Parag
   Sahay, Rakesh
   Shukla, Rishi
   Das, Sambit
   Tiwaskar, Mangesh
   Vijayakumar, G.
   Chawla, Manoj
   Eliana, Fatimah
   Suastika, Ketut
   Orabi, Abbas
   Rahim, Aly Ahmed Abdul
   Uloko, Andrew
   Lamptey, Roberta
   Ngugi, Nancy
   Bahendeka, Silver
   Abdela, Abdurezak Ahmed
   Mohammed, Fariduddin
   Pathan, Mohammed Faruque
   Rahman, Muhammed Hafizur
   Afsana, Faria
   Selim, Shajada
   Moosa, Muaz
   Murad, Moosa
   Shreshtha, Pradeep Krishna
   Shreshtha, Dina
   Giri, Mimi
   Hussain, Wiam
   Al-Ani, Ahmed
   Ramaiya, Kaushik
   Singh, Surender
   Raza, Syed Abbas
   Aye, Than Than
   Garusinghe, Chaminda
   Muthukuda, Dimuthu
   Weerakkody, Muditha
   Kahandawa, Shyaminda
   Bavuma, Charlotte
   Ruder, Sundeep
   Vanny, Koy
   Khanolkar, Manish
   Czupryniak, Leszek
TI Euthymia in Diabetes: Clinical Evidence and Practice-Based Opinion from
   an International Expert Group
SO DIABETES THERAPY
LA English
DT Review
DE Diabetes distress; Diabetes mellitus; Euthymia; Psychological; Stress
ID DISTRESS; DEPRESSION; PREVALENCE; PHYSICIANS; BURNOUT; PEOPLE
AB AimTo develop an evidence-based expert group opinion on various types of euthymia associated with diabetes mellitus (DM) and its management.BackgroundDiabetes mellitus is a metabolic syndrome characterized by diverse biomedical and psychosocial features. Emotional health disturbances may lead to psychological and psychiatric dysfunction and may negatively influence glycemic control. Patients with DM may experience diabetes distress (DD) associated with burden of self-care, interpersonal issues, and emotional worries regarding the ability to cope with the illness. Euthymia or a state of positive mental health and psychological well-being should be considered a key outcome of diabetes care. Therefore, to achieve optimal outcomes, the consideration and measurement of psychological and psychiatric aspects along with glycemic levels are very important. A group of multidisciplinary clinical experts came together in an international meeting held in India to develop a workable concept for euthymia in diabetes care. A multidisciplinary approach was suggested to enhance the clinical outcomes and facilitate patient-centered care. During the meeting emphasis was given to the concept of a euthymia model in diabetes care. This model focuses on enhancement of self-care skills in diabetic patients and preventative health awareness among diabetes care providers. Euthymia also encompasses patient-provider communication to aid enhancement of coping skills.ResultsAfter due discussions and extensive deliberations, the expert group provided several recommendations on implementing the concept of euthymia in DM care.ConclusionsIntroduction of the concept of euthymia in routine clinical practice is important to improve the quality of life and coping skills in patients with DM. A timely clinical assessment of psychological and psychiatric aspects along with patient-reported outcomes of diabetes contributes to overall health and well-being of affected individuals.FundingSanofi India.
C1 [Kalra, Sanjay] Bharti Hosp, Dept Endocrinol, Karnal, Haryana, India.
   [Kalra, Sanjay] BRIDE, Karnal, Haryana, India.
   [Das, A. K.] Pondicherry Inst Med Sci, Dept Endocrinol & Med, Pondicherry, India.
   [Baruah, M. P.] Excel Hosp, Dept Endocrinol, Gauhati, Assam, India.
   [Unnikrishnan, A. G.] Chellaram Diabet Inst, Dept Endocrinol & Diabet, Pune, Maharashtra, India.
   [Dasgupta, Arundhati] Rudraksh Superspecialty Care, Dept Endocrinol, Siliguri, India.
   [Shah, Parag] Gujarat Endocrine Ctr, Dept Endocrinol & Diabet, Ahmadabad, Gujarat, India.
   [Sahay, Rakesh] Osmania Med Coll & Hosp, Dept Endocrinol, Hyderabad, India.
   [Shukla, Rishi] Regency Hosp Ltd, Dept Endocrinol, Kanpur, Uttar Pradesh, India.
   [Das, Sambit] Apollo Hosp, Dept Endocrinol, Bhubaneswar, India.
   [Tiwaskar, Mangesh] Shilpa Med Res Ctr, Dept Diabetol, Mumbai, Maharashtra, India.
   [Vijayakumar, G.] Apollo Hosp, Dept Diabetol, Chennai, Tamil Nadu, India.
   [Chawla, Manoj] Lina Diabet Care, Dept Diabetol, Mumbai, Maharashtra, India.
   [Chawla, Manoj] Mumbai Diabet Res Ctr, Mumbai, Maharashtra, India.
   [Eliana, Fatimah] YARSI Univ, Fac Med, Dept Internal Med, Jakarta, Indonesia.
   [Suastika, Ketut] Indonesian Assoc Endocrinol, Jakarta, Indonesia.
   [Orabi, Abbas] Zagazig Univ, Fac Med, Dept Internal Med, Zagazig, Egypt.
   [Rahim, Aly Ahmed Abdul] Alexandria Univ, Dept Diabet & Metab, Alexandria, Egypt.
   [Uloko, Andrew] Aminu Kano Teaching Hosp, Dept Med, Kano, Nigeria.
   [Lamptey, Roberta] Univ Ghana, Sch Publ Hlth Ghana, Korle Bu Teaching Hosp, Dept Family Med, Accra, Ghana.
   [Ngugi, Nancy] Kenyatta Natl Hosp, Dept Internal Med & Diabet, Nairobi, Kenya.
   [Bahendeka, Silver] St Francis Hosp, Dept Internal Med Diabet & Endocrinol, Kampala, Uganda.
   [Abdela, Abdurezak Ahmed] Addis Ababa Univ, Dept Internal Med, Addis Ababa, Ethiopia.
   [Mohammed, Fariduddin] Mujib Med Univ, Dept Endocrinol Bangabandhu Sheikh, Dhaka, Bangladesh.
   [Pathan, Mohammed Faruque; Afsana, Faria] Bangladesh Inst Res & Rehabil Diabet, Endocrine & Metab Disorders BIRDEM, Dept Endocrinol, Dhaka, Bangladesh.
   [Rahman, Muhammed Hafizur] Dhaka Med Coll & Hosp, Dept Endocrinol, Dhaka, Bangladesh.
   [Selim, Shajada] Bangabandhu Sheikh Mujib Med Univ, Dept Endocrinol, Dhaka, Bangladesh.
   [Moosa, Muaz; Murad, Moosa] Indira Gandhi Mem Hosp, Dept Internal Med, Male, Maldives.
   [Shreshtha, Pradeep Krishna] Tribhuwan Univ, Teaching Hosp, Dept Internal Med, Kathmandu, Nepal.
   [Shreshtha, Dina] Norv Int Hosp Kathmandu, Dept Endocrinologist, Kathmandu, Nepal.
   [Giri, Mimi] Nepal Mediciti Hosp, Dept Endocrinol, Kathmandu, Nepal.
   [Hussain, Wiam] Awali Hosp, Royal Hosp, Dr Wiam Clin, Dept Endocrinol & Diabet, Awali, Bahrain.
   [Al-Ani, Ahmed] Hamad Hosp, Dept Internal Med, Doha, Qatar.
   [Ramaiya, Kaushik] Shree Hindu Mandal Hosp, Dept Diabetol, Dar Es Salaam, Tanzania.
   [Singh, Surender] Aster Al Raffah Hosp, Dept Internal Med, Muscat, Oman.
   [Raza, Syed Abbas] Shaukat Khanum Hosp & Res Ctr, Dept Endocrinol, Lahore, Pakistan.
   [Aye, Than Than] Myanmar Soc Endocrinol & Metab, Yangon, Myanmar.
   [Garusinghe, Chaminda] Colombo South Teaching Hosp, Dept Endocrinol, Colombo, Sri Lanka.
   [Muthukuda, Dimuthu] Sri Jayawardenapura Gen Hosp, Dept Endocrinol, Sri Jayawardenapure Kott, Sri Lanka.
   [Weerakkody, Muditha] Teaching Hosp Karapitiya, Dept Endocrinol, Galle, Sri Lanka.
   [Kahandawa, Shyaminda] Dist Gen Hosp, Dept Endocrinol, Matara, Sri Lanka.
   [Bavuma, Charlotte] Univ Rwanda, Coll Med & Hlth Sci, Kigali, Rwanda.
   [Ruder, Sundeep] Charlotte Maxeke Johannesburg Acad Hosp, Dept Endocrinol & Metab, Johannesburg, South Africa.
   [Vanny, Koy] Dr KoyVanny Diabet & Endocrine Clin, Dept Endocrinol & Diabet, Phnom Penh, Cambodia.
   [Khanolkar, Manish] Waikato Hosp, Dept Endocrinol & Diabet, Hamilton, New Zealand.
   [Czupryniak, Leszek] Med Univ Warsaw, Dept Diabetol & Internal Med, Warsaw, Poland.
C3 Pondicherry Institute of Medical Sciences; YARSI University; Egyptian
   Knowledge Bank (EKB); Zagazig University; Egyptian Knowledge Bank (EKB);
   Alexandria University; University of Ghana; Kenyatta National Hospital;
   Addis Ababa University; Bangabandhu Sheikh Mujib Medical University
   (BSMMU); Dhaka Medical College; Bangabandhu Sheikh Mujib Medical
   University (BSMMU); Tribhuvan University; Institute of Medicine (IoM) -
   Nepal; Hamad Medical Corporation; Hamad General Hospital; Colombo South
   Teaching Hospital; University of Rwanda; University of Witwatersrand;
   Johannesburg Academy Hospital; Waikato Hospital; Medical University of
   Warsaw
RP Kalra, S (corresponding author), Bharti Hosp, Dept Endocrinol, Karnal, Haryana, India.; Kalra, S (corresponding author), BRIDE, Karnal, Haryana, India.
EM brideknl@gmail.com
RI lamptey, roberta/U-1424-2019; Tiwaskar, Mangesh/AAE-6002-2020; Sahay,
   Rakesh/JAC-6753-2023; Raza, Syed/AAH-4078-2019; Selim,
   Shahjada/AAV-8959-2020
OI Kalra, Sanjay/0000-0003-1308-121X; Czupryniak,
   Leszek/0000-0003-2396-8885; Selim, Shahjada/0000-0001-7749-3542; Silver,
   Bahendeka/0000-0001-8080-7872; Tiwaskar, Mangesh/0000-0003-4024-0095;
   Sahay, Rakesh Kumar/0000-0002-5471-0695; Lamptey,
   Roberta/0000-0002-4260-9442
FU Sanofi India
FX This expert opinion initiative has been funded by Sanofi India. The
   article processing charges received by the journal were paid for by
   Sanofi India. All authors had full access to the articles reviewed in
   this manuscript and take complete responsibility for the integrity and
   accuracy of this manuscript.
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NR 29
TC 10
Z9 10
U1 1
U2 4
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1869-6953
EI 1869-6961
J9 DIABETES THER
JI Diabetes Ther.
PD JUN
PY 2019
VL 10
IS 3
BP 791
EP 804
DI 10.1007/s13300-019-0614-6
PG 14
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA HZ6JI
UT WOS:000468957700002
PM 31012081
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Van Guilder, GP
   Hoetzer, GL
   Greiner, JJ
   Stauffer, BL
   DeSouza, CA
AF Van Guilder, Gary P.
   Hoetzer, Greta L.
   Greiner, Jared J.
   Stauffer, Brian L.
   DeSouza, Christopher A.
TI Influence of metabolic syndrome on biomarkers of oxidative stress and
   inflammation in obese adults
SO OBESITY
LA English
DT Article
DE metabolic syndrome; oxidative stress; inflammation
ID LOW-DENSITY-LIPOPROTEIN; INSULIN-RESISTANCE; PLASMA; MARKER; RISK;
   ATHEROSCLEROSIS; ASSOCIATION; DISEASE
AB Objective: Both obesity and the metabolic syndrome (MetS) have been independently linked with increased oxidative and inflammatory stress. This study tested the hypothesis that obesity with MetS is associated with greater oxidative and inflammatory burden compared with obesity alone.
   Research Methods and Procedures: Forty-eight normal-weight and 40 obese (20 without MetS; 20 with MetS) adults were studied. MetS was defined according to National Cholesterol Education Program Adult Treatment Panel III criteria. Plasma concentrations of oxidized low-density lipoprotein, C-reactive protein, tumor necrosis factor-a, interleukin (IL)-6, and IL-18 were determined by enzyme immunoassay.
   Results: Plasma biomarkers of oxidative stress and inflammation were lowest in normal-weight controls. Of note, obese MetS adults demonstrated significantly higher plasma concentrations of oxidized low-density lipoprotein (62.3 +/- 3.2 vs. 54.0 +/- 4.0 U/L; p < 0.05), C-reactive protein (3.0 +/- 0.6 vs. 1.5 +/- 0.3 mg/L; p < 0.01), tumor necrosis factor-a (2.1 +/- 0.1 vs. 1.6 +/- 0.1 pg/mL; p < 0.05), IL-6 (2.8 +/- 0.4 vs. 1.4 +/- 0.2 pg/mL; p < 0.01), and IL-18 (253 +/- 16 vs. 199 +/- 16 pg/mL; p < 0.01), compared with obese adults without MetS.
   Discussion: These results suggest that MetS heightens oxidative stress and inflammatory burden in obese adults. Increased oxidative and inflammatory stress may contribute to the greater risk of coronary heart disease and cerebrovascular disease in obese adults with MetS.
C1 Univ Colorado, Dept Integrat Physiol, Integrat Vasc Biol Lab, Boulder, CO 80309 USA.
   Univ Colorado, Hlth Sci Ctr, Dept Med, Denver, CO 80202 USA.
   Denver Hlth Med Ctr, Denver, CO USA.
C3 University of Colorado System; University of Colorado Boulder;
   University of Colorado System; University of Colorado Anschutz Medical
   Campus; University of Colorado Denver; Denver Health Medical Center
RP DeSouza, CA (corresponding author), Univ Colorado, Dept Integrat Physiol, Integrat Vasc Biol Lab, 354 UCB, Boulder, CO 80309 USA.
EM desouzac@colorado.edu
RI Stauffer, Brian/W-8251-2019; Van Guilder, Gary/N-6611-2017
OI Stauffer, Brian/0000-0003-3418-7750; Van Guilder,
   Gary/0000-0002-4540-1903
FU NCRR NIH HHS [M01 RR00051] Funding Source: Medline; NHLBI NIH HHS [L30
   HL074758, HL068030, HL076434] Funding Source: Medline; NIDDK NIH HHS
   [DK062061] Funding Source: Medline
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NR 18
TC 172
Z9 187
U1 0
U2 13
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1930-7381
EI 1930-739X
J9 OBESITY
JI Obesity
PD DEC
PY 2006
VL 14
IS 12
BP 2127
EP 2131
DI 10.1038/oby.2006.248
PG 5
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 212OH
UT WOS:000249606200002
PM 17189537
DA 2025-06-11
ER

PT J
AU Baye, E
   Ukropcova, B
   Ukropec, J
   Hipkiss, A
   Aldini, G
   de Courten, B
AF Baye, Estifanos
   Ukropcova, Barbara
   Ukropec, Jozef
   Hipkiss, Alan
   Aldini, Giancarlo
   de Courten, Barbora
TI Physiological and therapeutic effects of carnosine on cardiometabolic
   risk and disease
SO AMINO ACIDS
LA English
DT Review
DE Carnosine; Skeletal muscle; Obesity; Insulin resistance; Type 2
   diabetes; Energy expenditure; Atherosclerosis; Cholesterol; Ischaemia
ID BETA-ALANINE SUPPLEMENTATION; GLYCATION END-PRODUCTS; SYMPATHETIC-NERVE
   ACTIVITY; PRO-INFLAMMATORY CYTOKINES; ACTIVATED PROTEIN-KINASE;
   LOW-GRADE INFLAMMATION; ALPHA-LIPOIC ACID; MUSCLE CARNOSINE; OXIDATIVE
   STRESS; DIABETIC-NEPHROPATHY
AB Obesity, type 2 diabetes (T2DM) and cardiovascular disease (CVD) are the most common preventable causes of morbidity and mortality worldwide. They represent major public health threat to our society. Increasing prevalence of obesity and T2DM contributes to escalating morbidity and mortality from CVD and stroke. Carnosine (beta-alanyl-L-histidine) is a dipeptide with anti-inflammatory, antioxidant, anti-glycation, anti-ischaemic and chelating roles and is available as an over-the-counter food supplement. Animal evidence suggests that carnosine may offer many promising therapeutic benefits for multiple chronic diseases due to these properties. Carnosine, traditionally used in exercise physiology to increase exercise performance, has potential preventative and therapeutic benefits in obesity, insulin resistance, T2DM and diabetic microvascular and macrovascular complications (CVD and stroke) as well as number of neurological and mental health conditions. However, relatively little evidence is available in humans. Thus, future studies should focus on well-designed clinical trials to confirm or refute a potential role of carnosine in the prevention and treatment of chronic diseases in humans, in addition to advancing knowledge from the basic science and animal studies.
C1 [Baye, Estifanos; de Courten, Barbora] Monash Univ, Monash Ctr Hlth Res & Implementat, Sch Publ Hlth & Prevent Med, 43-51 Kanooka Grove, Melbourne, Vic 3168, Australia.
   [Baye, Estifanos] Wollo Univ, Dept Publ Hlth, Coll Med & Hlth Sci, Dessie, Ethiopia.
   [Ukropcova, Barbara; Ukropec, Jozef] Slovak Acad Sci, Inst Expt Endocrinol, Bratislava, Slovakia.
   [Ukropcova, Barbara] Comenius Univ, Fac Med, Bratislava, Slovakia.
   [Hipkiss, Alan] Univ Birmingham, Sch Clin & Expt Med, Coll Med & Dent Sci, Birmingham, W Midlands, England.
   [Aldini, Giancarlo] Univ Milan, Dept Pharmaceut Sci, Milan, Italy.
   [de Courten, Barbora] Monash Hlth, Diabet & Vasc Med Unit, Clayton, Vic 3168, Australia.
C3 Monash University; Slovak Academy of Sciences; Institute of Experimental
   Endocrinology, SAS; Comenius University Bratislava; University of
   Birmingham; University of Milan; Monash Health
RP de Courten, B (corresponding author), Monash Univ, Monash Ctr Hlth Res & Implementat, Sch Publ Hlth & Prevent Med, 43-51 Kanooka Grove, Melbourne, Vic 3168, Australia.; de Courten, B (corresponding author), Monash Hlth, Diabet & Vasc Med Unit, Clayton, Vic 3168, Australia.
EM barbora.decourten@monash.edu
RI Ukropcova, Barbara/ABE-6186-2020; aldini, giancarlo/C-3533-2013;
   Ukropec, Jozef/D-5960-2018; de Courten, Barbora/B-3308-2012
OI Baye, Estifanos/0000-0002-2937-356X; Ukropcova,
   Barbara/0000-0002-3309-7713; Ukropec, Jozef/0000-0001-8401-6621; de
   Courten, Barbora/0000-0001-8760-2511
FU Monash Graduate Scholarship; Australian National Health and Medical
   Research Council
FX Estifanos Baye is a recipient of the Monash Graduate Scholarship.
   Barbora de Courten was supported by the Australian National Health and
   Medical Research Council.
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NR 202
TC 65
Z9 67
U1 2
U2 27
PU SPRINGER WIEN
PI WIEN
PA SACHSENPLATZ 4-6, PO BOX 89, A-1201 WIEN, AUSTRIA
SN 0939-4451
EI 1438-2199
J9 AMINO ACIDS
JI Amino Acids
PD MAY
PY 2016
VL 48
IS 5
BP 1131
EP 1149
DI 10.1007/s00726-016-2208-1
PG 19
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA DJ7ES
UT WOS:000374375300002
PM 26984320
DA 2025-06-11
ER

PT J
AU Kiraz, S
   Demir, E
AF Kiraz, Seda
   Demir, Emre
TI Global Scientific Outputs of Schizophrenia Publications From 1975 to
   2020: a Bibliometric Analysis
SO PSYCHIATRIC QUARTERLY
LA English
DT Article
DE Schizophrenia; Bibliometric analysis; Citation analysis; Trend topics
ID NEUROCOGNITIVE DEFICITS; ANTIPSYCHOTIC-DRUGS; ANNUAL PREVALENCE; BRAIN;
   RISK; METAANALYSIS; DEFINITION; DISORDERS; MUTATIONS; SYMPTOMS
AB Schizophrenia is a choronic, complex and powerfully inherited mental illness that seriously affects quality of life. The illness is one of the most researched psychiatric disorders from past to present. This study aims to provide a holistic summary of the global scientific outputs through bibliometric analyses and reveal the trend topics. The articles published between the years 1975 and 2020 were downloaded from the Web of Science (WoS) database and analyzed using bibliometric methods. The literature review was conducted using the keyword ''schizophren*'' in the ''Research Area'' category. The relation between the number of publications of the countries and the Gross Domestic Products and Human Development Index values were analyzed using Spearman's correlation coefficient. The number of articles between the years 2021 and 2032 was estimated through linear regression analysis.There were 103,992 publications, 51,117 of which were articles. The number of studies has increased in direct proportion to the development level of the countries. Schizophrenia Research was the most active journal. The most used research topics are cognition, negative symptoms, bipolar disorder, antipsychotics, depression, clozapine, quality of life. Trend keywords used in recent years are 'inflammation', 'biomarker', 'oxidative stress', 'Brain Derived Neurotrophic Factor (BDNF)', 'social cognition', 'metacognition', 'motivation', 'social functioning', 'functioning', 'mental health', 'metabolic syndrome', 'functional connectivity', 'adherence' and 'recovery' indicated new research frontiers in this field. Although schizophrenia has not been fully elucidated, studies are growing like an avalanche. Our study includes the most up-to-date and most comprehensive data ever made in this field.
C1 [Kiraz, Seda] Hitit Univ, Dept Psychiat, Erol Olcok Training & Res Hosp, Corum, Turkey.
   [Demir, Emre] Hitit Univ, Fac Med, Dept Biostat, Corum, Turkey.
C3 Hitit University; Hitit University
RP Kiraz, S (corresponding author), Hitit Univ, Dept Psychiat, Erol Olcok Training & Res Hosp, Corum, Turkey.
EM drsedakiraz@gmail.com; emredemir82@gmail.com
RI Demir, Emre/AAA-8193-2020; Kiraz, Seda/IXD-8648-2023
OI Kiraz, Seda/0000-0001-9393-6921
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NR 64
TC 38
Z9 38
U1 1
U2 38
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0033-2720
EI 1573-6709
J9 PSYCHIAT QUART
JI Psychiatr. Q.
PD DEC
PY 2021
VL 92
IS 4
BP 1725
EP 1744
DI 10.1007/s11126-021-09937-4
EA AUG 2021
PG 20
WC Psychiatry
WE Social Science Citation Index (SSCI)
SC Psychiatry
GA WK6BS
UT WOS:000680296500001
PM 34341886
DA 2025-06-11
ER

PT J
AU Ferrer, MD
   Capó, X
   Reynés, C
   Quetglas, M
   Salaberry, E
   Tonolo, F
   Suau, R
   Marí, B
   Tur, JA
   Sureda, A
   Pons, A
AF Ferrer, Miguel D.
   Capo, Xavier
   Reynes, Clara
   Quetglas, Magdalena
   Salaberry, Eduardo
   Tonolo, Federica
   Suau, Rafael
   Mari, Bartolome
   Tur, Josep A.
   Sureda, Antoni
   Pons, Antoni
TI Dietary Sodium Nitrate Activates Antioxidant and Mitochondrial Dynamics
   Genes after Moderate Intensity Acute Exercise in Metabolic Syndrome
   Patients
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Article
DE exercise; inflammation; metabolic syndrome; nitrate; oxidative stress;
   supplementation
ID ISCHEMIA-REPERFUSION INJURY; INORGANIC NITRATE; REACTIVE OXYGEN;
   NITRIC-OXIDE; PHYSICAL-ACTIVITY; OXIDATIVE STRESS; OLDER-ADULTS;
   MITOFUSIN 2; SUPPLEMENTATION; INFLAMMATION
AB Exercise can induce a pro-inflammatory response in aged subjects with metabolic disorders and nitrate supplementation has shown anti-inflammatory effects. We evaluated the influence of dietary nitrate on the response of the antioxidant and mitochondrial dynamics genes to acute exercise in peripheral blood mononuclear cells (PBMCs), as well as the antioxidant and the inflammatory response of PBMCs against immune stimulation. Metabolic syndrome patients participated in a crossover study in which they consumed a beverage containing 16 mM sodium nitrate or a placebo with the same composition without nitrate before performing a submaximal test at 60-70% of their maximal heart rate for 30 min. The intake of nitrate increased the nitrate plus nitrite plasma levels about 8-fold and induced the upregulation of catalase, superoxide dismutase, glutathione peroxidase, mitofusin 2 and PGC1 alpha in PBMCs after exercise. The gene expression of catalase and TNF alpha was enhanced by phorbol myristate acetate (PMA) only in the placebo group, while the glutathione peroxidase expression was enhanced by PMA only after nitrate intake. The intake of nitrate by metabolic syndrome patients induces an antioxidant and mitochondrial response to exercise at the same time that it attenuates the pro-inflammatory response to immune stimulation.
C1 [Ferrer, Miguel D.; Capo, Xavier; Reynes, Clara; Quetglas, Magdalena; Salaberry, Eduardo; Tur, Josep A.; Sureda, Antoni; Pons, Antoni] Hlth Res Inst Balearic Isl IdISBa, Res Grp Community Nutr & Oxidat Stress, Palma De Mallorca 07120, Spain.
   [Ferrer, Miguel D.; Capo, Xavier; Reynes, Clara; Quetglas, Magdalena; Salaberry, Eduardo; Tonolo, Federica; Tur, Josep A.; Sureda, Antoni; Pons, Antoni] Univ Balearic Isl, IUNICS, Res Grp Community Nutr & Oxidat Stress, Palma De Mallorca 07122, Spain.
   [Ferrer, Miguel D.; Capo, Xavier; Reynes, Clara; Quetglas, Magdalena; Salaberry, Eduardo; Tonolo, Federica; Tur, Josep A.; Sureda, Antoni; Pons, Antoni] Univ Balearic Isl, Lab Phys Act Sci, Palma De Mallorca 07122, Spain.
   [Capo, Xavier] Carlos III Hlth Inst, CIBEROBN Physiopathol Obes & Nutr CB12 03 30038, Madrid 28029, Spain.
   [Tonolo, Federica] Univ Padua, Dept Biomed Sci, I-35131 Padua, Italy.
   [Suau, Rafael; Mari, Bartolome] Consell Insular Mallorca, Sports Med Serv, Palma De Mallorca 07010, Spain.
C3 Institut Investigacio Sanitaria Illes Balears (IdISBa); Universitat de
   les Illes Balears; IUNICS; Universitat de les Illes Balears; CIBER -
   Centro de Investigacion Biomedica en Red; CIBEROBN; University of Padua
RP Ferrer, MD (corresponding author), Hlth Res Inst Balearic Isl IdISBa, Res Grp Community Nutr & Oxidat Stress, Palma De Mallorca 07120, Spain.; Ferrer, MD (corresponding author), Univ Balearic Isl, IUNICS, Res Grp Community Nutr & Oxidat Stress, Palma De Mallorca 07122, Spain.; Ferrer, MD (corresponding author), Univ Balearic Isl, Lab Phys Act Sci, Palma De Mallorca 07122, Spain.
EM miguel-david.ferrer@uib.es; xavier.capo@uib.es; clara.reynes@uib.es;
   m.quetglas@uib.es; eduardo.salaberry@uib.es;
   federica.tonolo@phd.unipd.it; rsuau@conselldemallorca.net;
   bmari@conselldemallorca.net; pep.tur@uib.es; antoni.sureda@uib.es;
   antonipons@uib.es
RI Sureda, Antoni/N-9588-2019; Tonolo, Federica/AAE-5237-2021; Capó,
   Xavier/AAD-6322-2022; Quetglas Llabrés, Maria/AAA-4412-2019; Reynés,
   Miguel/J-4206-2019; Tur, Josep/AAE-5748-2020; Tur, Josep/F-5576-2014;
   Pons, Antoni/L-4844-2014
OI Tur, Josep/0000-0002-6940-0761; Quetglas Llabres, Maria
   Magdalena/0000-0003-4155-7780; Tonolo, Federica/0000-0002-7780-8994;
   Ferrer, Miguel D./0000-0003-1924-7727; Pons, Antoni/0000-0003-2447-3868;
   , Antoni/0000-0001-8656-6838; REYNES CAPO, CLARA/0000-0002-2209-0284
FU Health Research Institute of the Balearic Islands (IdISBa, PRIMUS
   Program) [PRI19/10]; Government of the Balearic Islands [AAEE26/2017];
   Spanish Ministry of Economy and Competitiveness, Carlos III Health
   Institute [11/01791, 14/00636, Red Predimed-RETIC RD06/0045/1004];
   CIBEROBN Physiopathology of Obesity and Nutrition, Carlos III Health
   Institute [CB12/03/30038]; European Regional Development Fund; FOLIUM
   programme of IdISBa; Ministry of Science, Innovation and Universities of
   the Government of Spain
FX This work was supported by the Health Research Institute of the Balearic
   Islands (IdISBa, PRIMUS Program, grant number PRI19/10); the Government
   of the Balearic Islands (grant number AAEE26/2017); the Spanish Ministry
   of Economy and Competitiveness, Carlos III Health Institute (Projects
   11/01791 and 14/00636, Red Predimed-RETIC RD06/0045/1004), and CIBEROBN
   Physiopathology of Obesity and Nutrition, CB12/03/30038, Carlos III
   Health Institute), which is cofunded by the European Regional
   Development Fund. X.C. was funded by a FOLIUM programme of IdISBa. C.R.
   was funded by the Youth Guarantee program of the Ministry of Science,
   Innovation and Universities of the Government of Spain. The funders had
   no role in study design, data collection and analysis, decision to
   publish, or preparation of the manuscript.
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NR 70
TC 9
Z9 9
U1 1
U2 2
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD JUN
PY 2021
VL 10
IS 12
AR 2618
DI 10.3390/jcm10122618
PG 16
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA SY7NM
UT WOS:000666070000001
PM 34198661
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Park, KY
   Hong, SM
   Kim, KS
   Han, K
   Park, CY
AF Park, Kye-Yeung
   Hong, Sangmo
   Kim, Kyung-Soo
   Han, Kyungdo
   Park, Cheol-Young
TI Prolonged Use of Carnitine-Orotate Complex (Godex®) Is Associated with
   Improved Mortality: A Nationwide Cohort Study
SO JOURNAL OF PERSONALIZED MEDICINE
LA English
DT Article
DE carnitine; cardiometabolic risk factors; epidemiologic study; metabolic
   diseases; mortality
ID FATTY LIVER-DISEASE; CARDIOVASCULAR-DISEASE; OXIDATIVE STRESS; TYPE-2;
   METABOLISM; SUPPLEMENTATION; HOMEOSTASIS; FRUCTOSE; INJURY; BODY
AB Despite its hepatoprotective effects and favorable metabolic effects, the association between carnitine-orotate complex (Godex (R)) intake and mortality has never been investigated. We enrolled 13,413 adults who underwent national health examination and were prescribed the carnitine-orotate complex. Subjects were classified into three groups based on duration of using carnitine-orotate complex: <30, 30-180, and >= 180 days and were followed-up until 2019. Hazard ratios (HRs) and 95% confidence intervals (CIs) for all-cause mortality were estimated using Cox proportional hazards regression. During the follow-up period, 708 deaths were documented. Adjusted HR of mortality was 0.69 (95% CI 0.51-0.92) in those who used carnitine-orotate complex for >= 180 days compared to those who used it for <30 days. Use of carnitine-orotate complex for >= 180 days was associated with significantly reduced mortality in individuals with metabolic risk factors such as obesity, metabolic syndrome, dyslipidemia, and fatty liver than the shorter period of use. A significant interaction was observed in individuals with type 2 diabetes (HR 0.43, 95% CI 0.29-0.63, p-value 0.001). In this nationwide study, longer use of carnitine-orotate complex was associated with improved mortality compared to a shorter period of use, and the risk reductions were prominent in individuals with metabolic risk factors.
C1 [Park, Kye-Yeung] Hanyang Univ, Dept Family Med, Coll Med, Seoul 04763, South Korea.
   [Hong, Sangmo] Hanyang Univ Guri Hosp, Coll Med, Dept Internal Med, Guri Hosp, Guri 11923, South Korea.
   [Kim, Kyung-Soo] CHA Univ, CHA Bundang Med Ctr, Dept Internal Med, Sch Med, Seongnam 13497, South Korea.
   [Han, Kyungdo] Soongsil Univ, Dept Stat & Actuarial Sci, Seoul 06978, South Korea.
   [Park, Cheol-Young] Sungkyunkwan Univ, Kangbuk Samsung Hosp, Dept Internal Med, Sch Med, Seoul 03181, South Korea.
C3 Hanyang University; Pochon Cha University; Soongsil University;
   Sungkyunkwan University (SKKU)
RP Park, CY (corresponding author), Sungkyunkwan Univ, Kangbuk Samsung Hosp, Dept Internal Med, Sch Med, Seoul 03181, South Korea.
EM cydoctor@chol.com
RI Hong, Sangmo/C-9515-2018; Kim, Kyung-Soo/C-5577-2018
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NR 44
TC 0
Z9 0
U1 0
U2 1
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2075-4426
J9 J PERS MED
JI J. Pers. Med.
PD DEC
PY 2022
VL 12
IS 12
AR 1970
DI 10.3390/jpm12121970
PG 12
WC Health Care Sciences & Services; Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Health Care Sciences & Services; General & Internal Medicine
GA 7E1VZ
UT WOS:000900966100001
PM 36556191
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Kornicka, K
   Houston, J
   Marycz, K
AF Kornicka, Katarzyna
   Houston, Jenny
   Marycz, Krzysztof
TI Dysfunction of Mesenchymal Stem Cells Isolated from Metabolic Syndrome
   and Type 2 Diabetic Patients as Result of Oxidative Stress and Autophagy
   may Limit Their Potential Therapeutic Use
SO STEM CELL REVIEWS AND REPORTS
LA English
DT Review
DE Mesenchymal stem cells; Metabolic syndrome; Diabetes; Aging; Senescence;
   Regenerative medicine; Oxidative stress; Autophagy
ID HUMAN ADIPOSE-TISSUE; BONE-MARROW; OSTEOGENIC DIFFERENTIATION; PREMATURE
   SENESCENCE; INSULIN-RESISTANCE; RECEPTOR CD44; MICROVESICLES;
   REGENERATION; COMPLICATIONS; INFLAMMATION
AB Mesenchymal stem cells (MSC) have become a promising tool for therapeutic intervention. Their unique features, including self-renewal, multipotency and immunomodulatory properties draw the worldwide attention of researchers and physicians with respect to their application in disease treatment. However, the environment (so-called niche) from which MSCs are isolated may determine their usefulness. Many studies indicated the involvement of MSCs in ageing and disease. In this review, we have focused on how type 2 diabetes (T2D) and metabolic syndrome (MS) affect MSC properties, and thus limit their therapeutic potential. Herein, we mainly focus on apoptosis, autophagy and mitochondria deterioration processes that indirectly affect MSC fate. Based on the data presented, special attention should be paid when considering autologous MSC therapy in T2D or MS treatments, as their therapeutic potential may be restricted.
C1 [Kornicka, Katarzyna; Marycz, Krzysztof] Wroclaw Univ Environm & Life Sci, Fac Biol & Anim Sci, Dept Expt Biol, Norwida 25, PL-50375 Wroclaw, Poland.
   [Marycz, Krzysztof] Wroclaw Res Ctr EIT, PL-54066 Wroclaw, Poland.
   [Houston, Jenny] PferdePraxis Dr Med Vet Daniel Weiss, Postmatte 14, CH-8807 Freienbach, Switzerland.
C3 Wroclaw University of Environmental & Life Sciences
RP Kornicka, K (corresponding author), Wroclaw Univ Environm & Life Sci, Fac Biol & Anim Sci, Dept Expt Biol, Norwida 25, PL-50375 Wroclaw, Poland.
EM katarzyna.kornicka@upwr.edu.pl; d.weiss@horsedoc.ch;
   krzysztofmarycz@interia.pl
FU National Science Centre (NCN) [2016/21/B/NZ7/01111,
   2015/18/E/NZ9/00607]; Wroclaw Centre of Biotechnology, the Leading
   National Research Centre (KNOW) programme
FX The publication was supported by the National Science Centre (NCN)
   grants "Modulation mitochondrial metabolism and dynamics and tageting
   DNA methylation of adipose derived mesenchymal stromal stem cell (ASC)
   using resveratrol and 5-azacytydine as a therapeutic strategy in the
   course of Equine metabolic syndrome (EMS)." (2016/21/B/NZ7/01111) and
   "The effect of bioactive algae enriched by biosorption on the certain
   minerals such as Cr(III), Mg(II) and Mn(II) on the status of glucose in
   the course of metabolic syndrome horses. Evaluation in vitro and in
   vivo" (2015/18/E/NZ9/00607). The publication was supported by the
   Wroclaw Centre of Biotechnology, the Leading National Research Centre
   (KNOW) programme for years 2014-2018.
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NR 82
TC 133
Z9 141
U1 1
U2 28
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 2629-3269
EI 2629-3277
J9 STEM CELL REV REP
JI Stem Cell Rev. Rep.
PD JUN
PY 2018
VL 14
IS 3
BP 337
EP 345
DI 10.1007/s12015-018-9809-x
PG 9
WC Cell & Tissue Engineering; Cell Biology; Medicine, Research &
   Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Research & Experimental Medicine
GA GG7AV
UT WOS:000432851100005
PM 29611042
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Jia, GH
   Aroor, AR
   Martinez-Lemus, LA
   Sowers, JR
AF Jia, Guanghong
   Aroor, Annayya R.
   Martinez-Lemus, Luis A.
   Sowers, James R.
TI Mitochondrial functional impairment in response to environmental toxins
   in the cardiorenal metabolic syndrome
SO ARCHIVES OF TOXICOLOGY
LA English
DT Review
DE Toxins; Cardiorenal metabolic syndrome; Environmental pollution;
   Mitophagy; Mitochondria dysfunction; Reactive oxygen species
ID METHYLMERCURY-INDUCED NEUROTOXICITY; CELL-DEATH; OXIDATIVE STRESS;
   CARDIOVASCULAR-DISEASE; INSULIN-RESISTANCE; AUTOPHAGY; DYSFUNCTION;
   MECHANISMS; MERCURY; CROSSTALK
AB Environmental toxins can promote cardiovascular, metabolic, and renal abnormalities, which characterize the cardiorenal metabolic syndrome (CRS). Heavy metals, such as mercury and arsenic, represent two of the most toxic pollutants. Exposure to these toxins is increasing due to increased industrialization throughout much of the world. Studies conducted to understand the impact of environmental toxins have shown a major impact on mitochondrial structure and function. The maladaptive stress products caused by these toxins, including aggregated proteins, damaged organelles, and intracellular pathogens, can be removed through autophagy, which is also known as mitophagy in mitochondria. Although the underlying mechanisms involved in the regulation of mitophagy in response to pollution are not well understood, accumulating evidence supports a role for maladaptive mitochondrial responses to environmental pollution in the pathogenesis of the CRS. In this review, we discuss the ongoing research, which explores the mechanisms by which these toxins promote abnormalities in mitophagy and associated mitochondrial dysfunction and the CRS.
C1 [Jia, Guanghong; Aroor, Annayya R.; Sowers, James R.] Univ Missouri, Sch Med, Diabet Cardiovasc Ctr, Div Endocrinol Diabet & Metab, Columbia, MO 65212 USA.
   [Jia, Guanghong; Aroor, Annayya R.; Martinez-Lemus, Luis A.; Sowers, James R.] Univ Missouri, Sch Med, Harry S Truman Mem Vet Hosp, Columbia, MO 65212 USA.
   [Martinez-Lemus, Luis A.; Sowers, James R.] Univ Missouri, Sch Med, Dept Med Pharmacol & Physiol, Diabet Ctr HSC D109, Columbia, MO 65212 USA.
   [Martinez-Lemus, Luis A.; Sowers, James R.] Univ Missouri, Sch Med, Dalton Cardiovasc Res Ctr, Columbia, MO 65212 USA.
C3 University of Missouri System; University of Missouri Columbia;
   University of Missouri System; University of Missouri Columbia; US
   Department of Veterans Affairs; Veterans Health Administration (VHA);
   Harry S. Truman Memorial Veterans' Hospital; University of Missouri
   System; University of Missouri Columbia; University of Missouri System;
   University of Missouri Columbia
RP Sowers, JR (corresponding author), Univ Missouri, Sch Med, Dept Med Pharmacol & Physiol, Diabet Ctr HSC D109, One Hosp Dr, Columbia, MO 65212 USA.
EM sowersj@health.missouri.edu
FU NIH [R01 HL73101, R01 HL107910, R01 HL088105]; Veterans Affairs Merit
   System [0018]
FX The authors would like to thank Brenda Hunter for her editorial
   assistance. This research was supported by NIH (R01 HL73101, R01
   HL107910) and the Veterans Affairs Merit System (0018) for JRS, and NIH
   (R01 HL088105) for LAM.
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NR 53
TC 35
Z9 37
U1 0
U2 35
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0340-5761
EI 1432-0738
J9 ARCH TOXICOL
JI Arch. Toxicol.
PD FEB
PY 2015
VL 89
IS 2
BP 147
EP 153
DI 10.1007/s00204-014-1431-3
PG 7
WC Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Toxicology
GA CA4ZR
UT WOS:000348917100001
PM 25559775
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Sonnenberg, GE
   Krakower, GR
   Kissebah, AH
AF Sonnenberg, GE
   Krakower, GR
   Kissebah, AH
TI A novel pathway to the manifestations of metabolic syndrome
SO OBESITY RESEARCH
LA English
DT Article
DE adiponectin; TNF alpha; NF-kappa B; oxidative stress
ID TUMOR-NECROSIS-FACTOR; C-REACTIVE PROTEIN; KAPPA-B ACTIVATION;
   INTERCELLULAR-ADHESION MOLECULE-1; COMPLEMENT-RELATED PROTEIN;
   CORONARY-ARTERY-DISEASE; BODY-FAT DISTRIBUTION; INSULIN-RESISTANCE;
   FACTOR-ALPHA; TNF-ALPHA
AB Pathways leading from obesity to the manifestations of metabolic syndrome involve a number of metabolic risk factors, as well as adipokines, mediators of inflammatory response, thrombogenic and thrombolytic parameters, and vascular endothelial reactivity. Increased adipose tissue mass contributes to augmented secretion of proinflammatory adipokines, particularly tumor necrosis factor-alpha (TNFalpha), along with diminished secretion of the "protective" adiponectin. In our view, TNFalpha and adiponectin are antagonistic in stimulating nuclear transcription factor-kappaB (NF-kappaB) activation. Through this activation, TNFa induces oxidative stress, which exacerbates pathological processes leading to oxidized low-density lipoprotein and dyslipidemia, glucose intolerance, insulin resistance, hypertension, endothelial dysfunction, and atherogenesis. NF-kappaB activation further stimulates the formation of additional inflammatory cytokines, along with adhesion molecules which promote endothelial dysfunction. Elevated free fatty acid, glucose, and insulin levels enhance this NF-kappaB activation and further downstream modulate specific clinical manifestations of metabolic syndrome.
C1 Med Coll Wisconsin, Div Endocrinol Metab & Clin Nutr, Dept Med, Milwaukee, WI 53226 USA.
C3 Medical College of Wisconsin
RP Med Coll Wisconsin, Div Endocrinol Metab & Clin Nutr, Dept Med, 9200 W Wisconsin Ave, Milwaukee, WI 53226 USA.
EM gsonnen@mcw.edu
FU NCRR NIH HHS [RR00058] Funding Source: Medline; NIDDK NIH HHS [DK54026]
   Funding Source: Medline
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NR 100
TC 176
Z9 205
U1 1
U2 3
PU NORTH AMER ASSOC STUDY OBESITY
PI SILVER SPRING
PA 8630 FENTON ST, SUITE 918, SILVER SPRING, MD 20910 USA
SN 1071-7323
J9 OBES RES
JI Obes. Res.
PD FEB
PY 2004
VL 12
IS 2
BP 180
EP 186
DI 10.1038/oby.2004.24
PG 7
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 779TX
UT WOS:000189318000002
PM 14981209
OA Bronze
DA 2025-06-11
ER

PT J
AU Li, CH
   Shi, L
   Zhan, GL
   Rao, SZ
   Zhang, H
AF Li, C. -H.
   Shi, L.
   Zhan, G. -L.
   Rao, S. -Z.
   Zhang, H.
TI A twenty-four-week, open-label study on Ziprasidone's efficacy and
   influence on glucolipid metabolism in patients with schizophrenia and
   metabolic disorder
SO EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
LA English
DT Article
DE Ziprasidone; Clozapine; Schizophrenia; Metabolic syndrome
ID IMPROVEMENT; OLANZAPINE; CLOZAPINE; ANTIPSYCHOTICS; TOLERABILITY;
   MULTICENTER; OUTPATIENTS; RISPERIDONE; SAFETY; SWITCH
AB BACKGROUND: The risks of antipsychotic drugs on metabolic syndrome (MS) present many challenges for psychiatrists.
   AIM: To evaluate the effectiveness and influences on glucolipid metabolism in patients with schizophrenia and metabolic disorders switched from clozapine to ziprasidone.
   PATIENTS AND METHODS: Schizophrenic patients with metabolic syndrome who had been treated with clozapine for 2 years were enrolled in the open-label study. All the patients were switched to ziprasidone from clozapine and followed up for 24-week. The primary end-points included body mass index (BMI), fasting glucose (FG), triglycerides (TG), HDL cholesterol (HDL-c) and systolic pressure (SP)/diastolic pressure (DP). Secondary endpoints included scores on the Positive and Negative Syndrome Scale (PANSS) and treatment emergent symptom scale (TESS).
   RESULTS: A total of 213 cases satisfied the inclusion and exclusion criteria, but only 194 cases eventually completed the 24-week follow-up and were divided into ziprasidone group (n=68, complete substitution) and combined treatment group (n=126, partial substitution). In the ziprasidone group, TG at 4th and 24th week, BMI and HDL-c at 24th week were significantly improved (p < 0.05), while cognitive scores and total score of the PANSS at 4th and 24th week, negative factor, the factor of anxiety and depression at 24th week were significantly lower than those at the baseline (p < 0.05); In the combined group, cognitive factor scores (4 weekend, 24 weekends) and total score of PANSS (24 weeks) was significantly lower than baseline (p < 0.05). There was no significant difference in the TESS score (p > 0.05).
   CONCLUSIONS: Ziprasidone completely or partially substituting clozapine can improve both glucolipid metabolism disorders, and cognitive disorders and affective disorders of schizophrenia.
C1 [Li, C. -H.; Shi, L.; Zhan, G. -L.; Rao, S. -Z.; Zhang, H.] Shanghai Xuhui Dist Mental Hlth Ctr, Dept Psychiat, Shanghai, Peoples R China.
RP Li, CH (corresponding author), Shanghai Xuhui Dist Mental Hlth Ctr, Dept Psychiat, Shanghai, Peoples R China.
EM lichenhuxh@hotmail.com
FU Xuhui Health Bureau scientific research found of Shanghai
FX This study was financially supported by grants from Xuhui Health Bureau
   scientific research found of Shanghai.Statement of Interests:1. Authors'
   declaration of personal interests: None.2. Declaration of funding
   interests: This study was funded in fullby by grants from Xuhui Health
   Bureau scientific research found of Shanghai.
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NR 18
TC 8
Z9 11
U1 0
U2 3
PU VERDUCI PUBLISHER
PI ROME
PA VIA GREGORIO VII, ROME, 186-00165, ITALY
SN 1128-3602
J9 EUR REV MED PHARMACO
JI Eur. Rev. Med. Pharmacol. Sci.
PD AUG
PY 2013
VL 17
IS 16
BP 2136
EP 2140
PG 5
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 228RG
UT WOS:000325204300002
PM 23893178
DA 2025-06-11
ER

PT J
AU Benkhaled, A
   Réggami, Y
   Boudjelal, A
   Senator, A
   Bouriche, H
   Demirtas, I
   Kheniche, A
   Benyettou, H
   Larabi, N
   Ruberto, G
AF Benkhaled, Abderrahim
   Reggami, Yassine
   Boudjelal, Amel
   Senator, Abderrahmane
   Bouriche, Hamama
   Demirtas, Ibrahim
   Kheniche, Abdelhakim
   Benyettou, Halima
   Larabi, Nadia
   Ruberto, Giuseppe
TI Chemical characterisation, hypoglycaemic and renoprotective effects of
   aqueous leaf extract of Limoniastrum guyonianum on
   fructose-induced metabolic syndrome in rats
SO ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
LA English
DT Article
DE Limoniastrum guyonianum; HPLC-TOF; MS; fructose; insulin resistance;
   renoprotective
ID DENSITY-LIPOPROTEIN CHOLESTEROL; INSULIN-RESISTANCE; OXIDATIVE STRESS;
   URIC-ACID; SERUM; PLASMA; HYPERGLYCEMIA; CARBOHYDRATE; GLUTATHIONE;
   GLUCOSE
AB In the present study, we chemically characterised the aqueous leaf extract of Limoniastrum guyonianum by HPLC-TOF/MS and evaluated its effects on fructose-induced metabolic syndrome (MetS) in Wistar rats. MetS groups were given (10% w/v) fructose solution to drink ad libitum for 9 weeks, whereas, normal animals received ordinary water. LG extract was administrated to treated groups by gavage for the last 6 weeks of the experimental period. Fructose feeding as a liquid solution increased body weight, reduced insulin sensitivity, raised blood glucose level and provoked atherogenic dyslipidemia associated with renal oxidative stress and structural damage. Treating MetS rats with LG extract at doses of 100, 200 and 300 mg/kg b.w./day considerably ameliorated the fructose-induced alterations. From this study, it was concluded that aqueous leaf extract of L. guyonianum possesses hypoglycaemic, hypolipidemic, antioxidant and renoprotective abilities against fructose-induced metabolic syndrome in rats.
C1 [Benkhaled, Abderrahim; Reggami, Yassine; Boudjelal, Amel; Kheniche, Abdelhakim; Benyettou, Halima; Larabi, Nadia] Mohamed Boudiaf Msila Univ, Dept Microbiol & Biochem, Fac Sci, Msila, Algeria.
   [Reggami, Yassine] Badji Mokhtar Annaba Univ, Dept Biochem, Lab Biochem & Appl Microbiol, Fac Sci, Annaba, Algeria.
   [Senator, Abderrahmane; Bouriche, Hamama] Ferhat Abbas Setif Univ, Fac Nat & Life Sci, Lab Appl Biochem, Setif, Algeria.
   [Demirtas, Ibrahim] Cankiri Karatekin Univ, Dept Chem, Plant Res Lab, Cankiri, Turkey.
   [Ruberto, Giuseppe] CNR, ICB, Catania, Italy.
C3 Universite Badji Mokhtar - Annaba; Cankiri Karatekin University;
   Consiglio Nazionale delle Ricerche (CNR); Istituto di Chimica
   Biomolecolare (ICB-CNR)
RP Ruberto, G (corresponding author), Ist CNR Chim Biomol, Via Paolo Gaifami 18, I-95126 Catania, Italy.
EM giuseppe.ruberto@icb.cnr.it
RI Benkhaled, Abderrahim/AAK-1283-2021; Reggami, Yassine/G-3660-2016;
   demirtas, ibrahim/C-7274-2013
OI Ruberto, Giuseppe/0000-0002-6610-6110; Abderrahim,
   Benkhaled/0000-0003-4635-1626; Reggami, Yassine/0000-0003-3780-2333;
   Kheniche, Abdelhakim/0000-0003-1625-3515; demirtas,
   ibrahim/0000-0001-8946-647X
FU Algerian Ministry of Higher Education and Scientific Research, via
   Mohamed Boudiaf-M'sila University, Algeria [CNEPRU
   DO1N01UN280120150001]; Consiglio Nazionale delle Ricerche, Rome, Italy
FX This work was supported by Algerian Ministry of Higher Education and
   Scientific Research, via Mohamed Boudiaf-M'sila University, Algeria:
   CNEPRU DO1N01UN280120150001; and the Consiglio Nazionale delle Ricerche,
   Rome, Italy.
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NR 53
TC 7
Z9 7
U1 0
U2 10
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1381-3455
EI 1744-4160
J9 ARCH PHYSIOL BIOCHEM
JI Arch. Physiol. Biochem.
PD JUL 4
PY 2022
VL 128
IS 4
BP 914
EP 923
DI 10.1080/13813455.2020.1739715
EA MAR 2020
PG 10
WC Biochemistry & Molecular Biology; Biophysics; Endocrinology &
   Metabolism; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Endocrinology &
   Metabolism; Physiology
GA 3L5FL
UT WOS:000524716200001
PM 32188282
DA 2025-06-11
ER

PT J
AU Giuliante, R
   Sartini, D
   Bacchetti, T
   Rocchetti, R
   Klöting, I
   Polidori, C
   Ferretti, G
   Emanuelli, M
AF Giuliante, Rachela
   Sartini, Davide
   Bacchetti, Tiziana
   Rocchetti, Romina
   Kloeting, Ingrid
   Polidori, Carlo
   Ferretti, Gianna
   Emanuelli, Monica
TI Potential Involvement of Nicotinamide N-Methyltransferase in the
   Pathogenesis of Metabolic Syndrome
SO METABOLIC SYNDROME AND RELATED DISORDERS
LA English
DT Article
ID UP-REGULATION; INSULIN-RESISTANCE; HOMOCYSTEINE; EXPRESSION; TISSUE;
   KNOCKDOWN; STRESS; PLASMA; RISK; GENE
AB Background: Metabolic syndrome is a complex disorder characterized by the presence of insulin resistance (IR), type 2 diabetes mellitus (T2DM), impaired glucose tolerance (IGT), or impaired fasting glucose (IFG), plus at least two of the following conditions-hypertension, hyperlipidemia, obesity, and microalbuminuria. Metabolic syndrome exposes patients to a greater risk of developing cardiovascular disease (CVD) and is often associated with elevated levels of homocysteine (Hcy). In the current work, we analyzed the expression of nicotinamide N-methyltransferase (NNMT). Because NNMT is involved in Hcy metabolism and participates in the regulation of the cellular and plasma levels of this compound, we explored the role played by the enzyme in metabolic syndrome.
   Methods: Real-time PCR, immunohistochemistry, western blot analysis, and catalytic activity assay were performed to evaluate NNMT expression levels in adipose tissue from 10 Wistar Ottawa Karlsburg W (WOKW) rats, which are an animal model for metabolic syndrome, and from 10 Dark Agouti (DA) rats as the disease-resistant control strain.
   Results: NNMT mRNA, protein, and activity levels were significantly higher in adipose tissue obtained from WOKW rats compared with those observed in adipose tissue of DA rats.
   Conclusion: Data reported in this study represent the first evidence supporting the hypothesis that NNMT could play an important role in the pathogenesis of metabolic syndrome and could have a potential for the development of a targeted therapy.
C1 [Giuliante, Rachela; Sartini, Davide; Ferretti, Gianna; Emanuelli, Monica] Polytech Univ Marche, Dept Clin Sci, I-60131 Ancona, Italy.
   [Bacchetti, Tiziana] Polytech Univ Marche, Dept Life Sci & Environm, I-60131 Ancona, Italy.
   [Rocchetti, Romina] Polytech Univ Marche, Dept Biomed Sci & Publ Hlth, I-60131 Ancona, Italy.
   [Kloeting, Ingrid] Ernst Moritz Arndt Univ Greifswald, Fac Med, Dept Lab Anim Sci, Karlsburg, Germany.
   [Polidori, Carlo] Univ Camerino, Sch Pharm, I-62032 Camerino, Italy.
C3 Marche Polytechnic University; Marche Polytechnic University; Marche
   Polytechnic University; Universitat Greifswald; University of Camerino
RP Emanuelli, M (corresponding author), Polytech Univ Marche, Dept Clin Sci, Via Ranieri 65, I-60131 Ancona, Italy.
EM m.emanuelli@univpm.it
OI Ferretti, Gianna/0000-0001-7879-7935; SARTINI,
   Davide/0000-0003-3879-8647; Bacchetti, Tiziana/0000-0003-3346-9588
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NR 33
TC 18
Z9 18
U1 0
U2 18
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-4196
EI 1557-8518
J9 METAB SYNDR RELAT D
JI Metab. Syndr. Relat. Disord.
PD MAY 1
PY 2015
VL 13
IS 4
BP 165
EP 170
DI 10.1089/met.2014.0134
PG 6
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA CG6DU
UT WOS:000353386800003
PM 25719492
DA 2025-06-11
ER

PT J
AU Wasilewska, N
   Lebensztejn, DM
AF Wasilewska, Natalia
   Lebensztejn, Dariusz Marek
TI Non-alcoholic fatty liver disease and lipotoxicity
SO CLINICAL AND EXPERIMENTAL HEPATOLOGY
LA English
DT Review
DE non-alcoholic fatty liver disease; lipotoxicity; non-alcoholic
   steatohepatitis
ID CIRCULATING OXIDIZED-LDL; METABOLIC SYNDROME; INSULIN-RESISTANCE;
   CARDIOVASCULAR-DISEASE; HEPATIC STEATOSIS; OXIDATIVE STRESS; CHILDREN;
   PATHOGENESIS; OBESITY; CERAMIDES
AB Non-alcoholic fatty liver disease (NAFLD) has become the most common liver pathology worldwide due to the rising prevalence of obesity. This term includes changes from simple steatosis to steatohepatitis and fibrosis. It was previously thought to be a hepatic manifestation of metabolic syndrome, but recent literature describes this relation as much more complex and bi-directional. Development of NAFLD is associated with other metabolic syndrome components but it can also exacerbate insulin resistance and increase cardiovascular risk. Recently a lot of attention is brought to the role of lipids and lipotoxicity in pathogenesis and progression of non-alcoholic fatty disease. It seems that some lipid classes can be protective against liver injury while others are harmful in excessive amounts. This study presents an overview of the main lipids involved in the pathogenesis of non-alcoholic fatty liver disease and summarizes their association with lipotoxicity, insulin resistance, oxidative stress and other processes responsible for its progression.
C1 [Wasilewska, Natalia; Lebensztejn, Dariusz Marek] Med Univ Bialystok, Dept Pediat Gastroenterol Hepatol Nutr & Allergol, 17 Waszyngtona St, PL-15274 Bialystok, Poland.
C3 Medical University of Bialystok
RP Wasilewska, N (corresponding author), Med Univ Bialystok, Dept Pediat Gastroenterol Hepatol Nutr & Allergol, 17 Waszyngtona St, PL-15274 Bialystok, Poland.
EM nwasilewska@interia.pl
RI Lebensztejn, Dariusz/AAE-3166-2020
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NR 75
TC 27
Z9 28
U1 5
U2 58
PU TERMEDIA PUBLISHING HOUSE LTD
PI POZNAN
PA KLEEBERGA 2, POZNAN, 61-615, POLAND
SN 2392-1099
EI 2449-8238
J9 CLIN EXP HEPATOL
JI CLIN. EXP. HEPATOL.
PY 2021
VL 7
IS 1
BP 1
EP 6
DI 10.5114/ceh.2021.104441
PG 6
WC Gastroenterology & Hepatology
WE Emerging Sources Citation Index (ESCI)
SC Gastroenterology & Hepatology
GA RH8KX
UT WOS:000636461400001
PM 34027109
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Wester, VL
   Lamberts, SWJ
   van Rossum, EFC
AF Wester, Vincent L.
   Lamberts, Steven W. J.
   van Rossum, Elisabeth F. C.
TI Advances in the assessment of cortisol exposure and sensitivity
SO CURRENT OPINION IN ENDOCRINOLOGY DIABETES AND OBESITY
LA English
DT Review
DE cortisol; glucocorticoid receptor; glucocorticoids; metabolic syndrome;
   obesity
ID GLUCOCORTICOID-RECEPTOR GENE; LONG-TERM CORTISOL;
   POSTTRAUMATIC-STRESS-DISORDER; HAIR CORTISOL; ER22/23EK POLYMORPHISM;
   CUSHINGS-SYNDROME; SCALP HAIR; IN-VIVO; RISK; TRANSREPRESSION
AB Purpose of review
   To review recent progress in the field of cortisol exposure and sensitivity, and its implications for research concerning obesity and related metabolic disturbances.
   Recent findings
   In the past few years, scalp hair analysis had been successfully introduced as a marker for long-term cortisol exposure. With this relatively novel method, increased long-term cortisol levels have been linked to cardiovascular disease, metabolic syndrome, and stress-related measures. At the tissue level, the effect of cortisol is modulated by genetically determined glucocorticoid sensitivity. Polymorphisms in the glucocorticoid receptor gene that influence glucocorticoid sensitivity have been associated with differences in metabolic syndrome components.
   Summary
   Hair analysis provides exciting new opportunities to study the influence of long-term cortisol exposure on a wide range of health outcomes, in both observational and interventional studies. We propose that addition of genetically determined glucocorticoid sensitivity to these studies may bring about a more thorough understanding of the long-term effects of cortisol.
C1 [Wester, Vincent L.; Lamberts, Steven W. J.; van Rossum, Elisabeth F. C.] Erasmus MC, Univ Med Ctr Rotterdam, Dept Internal Med, NL-3000 CA Rotterdam, Netherlands.
C3 Erasmus University Rotterdam; Erasmus MC
RP van Rossum, EFC (corresponding author), Erasmus MC, Room D428,POB 2040, NL-3000 CA Rotterdam, Netherlands.
EM e.vanrossum@erasmusmc.nl
RI van Rossum, Elisabeth/AAP-9388-2020
OI van Rossum, Elisabeth/0000-0003-0120-4913; Wester,
   Vincent/0000-0002-0971-2739
FU Netherlands Organisation for Scientific Research (NWO) [916.96.069]
FX The present work was supported by the Netherlands Organisation for
   Scientific Research (NWO) grant number 916.96.069.
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NR 41
TC 20
Z9 23
U1 0
U2 19
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1752-296X
EI 1752-2978
J9 CURR OPIN ENDOCRINOL
JI Curr. Opin. Endocrinol. Diabetes Obes.
PD AUG
PY 2014
VL 21
IS 4
BP 306
EP 311
DI 10.1097/MED.0000000000000077
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA AK0UF
UT WOS:000338130600009
PM 24983396
DA 2025-06-11
ER

PT J
AU Cangemi, R
   Angelico, F
   Loffredo, L
   Del Ben, M
   Pignatelli, P
   Martini, A
   Violi, F
AF Cangemi, Roberto
   Angelico, Francesco
   Loffredo, Lorenzo
   Del Ben, Maria
   Pignatelli, Pascuale
   Martini, Alessandra
   Violi, Francesco
TI Oxidative stress-mediated arterial dysfunction in patients with
   metabolic syndrome: Effect of ascorbic acid
SO FREE RADICAL BIOLOGY AND MEDICINE
LA English
DT Article
DE metabolic syndrome; oxidative stress; flow-mediated dilation; ascorbic
   acid; free radicals
ID IMPROVES ENDOTHELIAL FUNCTION; NITRIC-OXIDE SYNTHESIS; VITAMIN-C;
   CARDIOVASCULAR EVENTS; INSULIN-RESISTANCE; NADPH OXIDASE; RISK;
   ANTIOXIDANT; SUPEROXIDE; CHILDREN
AB Arterial dysfunction is a hallmark of early atherosclerosis; however, its behavior in patients with metabolic syndrome (MS) is still unclear. We investigated the role of oxidative stress on ischemia-induced flow-mediated dilatation (FMD) in patients with MS. FMD and oxidative stress, as assessed by serum levels of 8-hydroxy-2-deoxy-2-deoxyguanosine (8-OHdG), were studied in 18 MS and 30 control subjects. Thereafter, in the 18 MS patients, FMD was assessed after iv infusion of 1 g vitamin C or placebo in a randomized, double-blind, crossover design; serial blood samples were taken in peripheral circulation before and after FMD to analyze 8-OHdG. Compared to controls, MS patients had higher 8-OHdG (p < 0.001) and lower FMD (p < 0.001); 8-OHdG and FMD were inversely correlated (R=-0.74; p < 0.01). In MS patients, placebo administration did not change FMD, whereas vitamin C significantly enhanced it (p < 0.001). After placebo, ischemia-induced FMD was associated with a significant increase in 8-OHdG (p < 0.001), an effect that was counteracted by vitamin C. Vitamin C infusion was associated with an inverse correlation between the changes in FMD and oxidative stress (R=-0.67; p < 0.01). The present study shows that arterial dilatation is impaired and that enhanced oxidative stress may play a key role in patients with MS. (c) 2007 Elsevier Inc. All rights reserved.
C1 Univ Roma La Sapienza, Dept Expt Med & Pathol, I-00161 Rome, Italy.
C3 Sapienza University Rome
RP Violi, F (corresponding author), Univ Roma La Sapienza, Dept Expt Med & Pathol, Piazzale Aldo Moro 5, I-00161 Rome, Italy.
EM francesco.violi@uniroma1.it
RI Angelico, Francesco/AAB-6585-2020; Carnevale, Roberto/JMC-1138-2023; Del
   Ben, Maria/AAE-7603-2020; pignatelli, pasquale/K-2116-2016; Loffredo,
   Lorenzo/K-4873-2016; Violi, Francesco/K-1509-2016
OI pignatelli, pasquale/0000-0002-2265-7455; Loffredo,
   Lorenzo/0000-0002-6542-6235; Violi, Francesco/0000-0002-6610-7068;
   Cangemi, Roberto/0000-0002-4097-2061
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NR 45
TC 59
Z9 65
U1 0
U2 10
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0891-5849
EI 1873-4596
J9 FREE RADICAL BIO MED
JI Free Radic. Biol. Med.
PD SEP 1
PY 2007
VL 43
IS 5
BP 853
EP 859
DI 10.1016/j.freeradbiomed.2007.06.002
PG 7
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 199ER
UT WOS:000248679500021
PM 17664149
DA 2025-06-11
ER

PT J
AU Loevinger, BL
   Muller, D
   Alonso, C
   Coe, CL
AF Loevinger, Barbara L.
   Muller, Daniel
   Alonso, Carnien
   Coe, Christopher L.
TI Metabolic syndrome in women with chronic pain
SO METABOLISM-CLINICAL AND EXPERIMENTAL
LA English
DT Article
ID PITUITARY-ADRENAL AXIS; SYMPATHETIC-NERVOUS-SYSTEM; INSULIN-RESISTANCE;
   CORTISOL SECRETION; FIBROMYALGIA; STRESS; DISORDERS; FEATURES; OBESITY;
   RISK
AB Fibromyalgia is a prevalent syndrome characterized by chronic pain, fatigue, and insomnia. Patients with fibromyalgia commonly have an elevated body mass index and are physically inactive, 2 major risk factors for metabolic syndrome. Yet little is known about the relationship between chronic pain conditions and metabolic disturbances. Our study evaluated the risk for, and neuroendocrine correlates of, metabolic syndrome in this patient population. Women with fibromyalgia (n = 109) were compared with control healthy women (n = 46), all recruited from the community. Metabolic syndrome was identified by using criteria from the Adult Treatment Panel III with glycosylated hemoglobin concentrations substituted for serum glucose. Catecholamine and cortisol levels were determined from 12-hour overnight urine collections. Women with fibromyalgia were 5.56 times more likely than healthy controls to have metabolic syndrome (95% confidence interval, 1.25-24.74). Fibromyalgia was associated with larger waist circumference (P = .04), higher glycosylated hemoglobin (P = .01) and serum triglyceride (P < .001) levels, and higher systolic (P = .003) and diastolic (P = .002) blood pressure. Total and low-density lipoprotein cholesterol were also significantly higher in women with fibromyalgia (P = .001 and .02, respectively), although high-density lipoprotein cholesterol was in the reference range. These associations were not accounted for by age or body mass index. Meeting criteria for more metabolic syndrome components was related to higher urinary norepinephrine (NE)/epinephrine and NE/cortisol ratios (P < .001 and P = .009, respectively). Women with chronic pain from fibromyalgia are at an increased risk for metabolic syndrome, which may be associated with relatively elevated NE levels in conjunction with relatively reduced epinephrine and cortisol secretion. (c) 2007 Elsevier Inc. All rights reserved.
C1 Univ Wisconsin, Sch Med & Publ Hlth, Ctr Womens Hlth Res, Madison, WI 53715 USA.
   Univ Wisconsin, Sch Med & Publ Hlth, Dept Med Rheumatol, Madison, WI 53715 USA.
   Univ Wisconsin, Dept Psychol, Madison, WI 53706 USA.
C3 University of Wisconsin System; University of Wisconsin Madison;
   University of Wisconsin System; University of Wisconsin Madison;
   University of Wisconsin System; University of Wisconsin Madison
RP Loevinger, BL (corresponding author), Univ Wisconsin, Sch Med & Publ Hlth, Ctr Womens Hlth Res, 1223 Capitol Court, Madison, WI 53715 USA.
EM bloeving@wisc.edu
FU NCRR NIH HHS [M01 RR03186] Funding Source: Medline; NHLBI NIH HHS [K30
   HL04100] Funding Source: Medline; NIAID NIH HHS [AI46521] Funding
   Source: Medline; NIA NIH HHS [T32AG00265, AG20166] Funding Source:
   Medline; NICHD NIH HHS [HD38305] Funding Source: Medline; NIMH NIH HHS
   [MH61083] Funding Source: Medline
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NR 49
TC 96
Z9 108
U1 0
U2 6
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0026-0495
EI 1532-8600
J9 METABOLISM
JI Metab.-Clin. Exp.
PD JAN
PY 2007
VL 56
IS 1
BP 87
EP 93
DI 10.1016/j.metabol.2006.09.001
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 119RB
UT WOS:000243029600013
PM 17161230
DA 2025-06-11
ER

PT J
AU Block, A
   Schipf, S
   Van der Auwera, S
   Hannemann, A
   Nauck, M
   John, U
   Völzke, H
   Freyberger, HJ
   Dörr, M
   Felix, S
   Zygmunt, M
   Wallaschofski, H
   Grabe, HJ
AF Block, Andrea
   Schipf, Sabine
   Van der Auwera, Sandra
   Hannemann, Anke
   Nauck, Matthias
   John, Ulrich
   Voelzke, Henry
   Freyberger, Harald Juergen
   Doerr, Marcus
   Felix, Stephan
   Zygmunt, Marek
   Wallaschofski, Henri
   Grabe, Hans Joergen
TI Sex- and age-specific associations between major depressive disorder and
   metabolic syndrome in two general population samples in Germany
SO NORDIC JOURNAL OF PSYCHIATRY
LA English
DT Article
DE Age effects; depression; major depressive disorder; metabolic syndrome;
   population-based studies; sex effects
ID 3RD NATIONAL-HEALTH; RISK-FACTOR; VISCERAL FAT; YOUNG-ADULTS; US ADULTS;
   PREVALENCE; SYMPTOMS; ANXIETY; OBESITY; COOCCURRENCE
AB Background and aims: Major depressive disorder (MDD) has been associated with the Metabolic Syndrome (MetS). As previous data strongly suggested sex and age effects on this association, this study aimed to analyse the association between MDD and MetS in two general population samples under explicit consideration of sex and age.Methods: This study analysed cross-sectional data based on two independent general population samples: SHIP-0 (n=4083; 20-81 years; 49.4% male) and SHIP-TREND-0 (n=3957; 20-83 years; 49.0% male) that were part of the Study of Health in Pomerania. MDD (SHIP-0: 12.6%; SHIP-TREND-0: 27.2%) was assessed using the Composite International Diagnostic-Screener (CID-S) in both samples. Interview assessment of MDD diagnosis according to Diagnostic and Statistical Manual of Mental Disorders IV (DSM-IV) criteria was performed in SHIP-TREND-0 (18.1% MDD). MetS was defined by abdominal obesity, elevated blood pressure, elevated glucose, elevated triglycerides and reduced high-density lipoprotein cholesterol according to established criteria. Data analysis was performed sex- and age-stratified.Results: Prevalence of MetS was high in both samples: 19.4% of females and 30.2% of males in SHIP-0 and 22.1% and 33.2% in SHIP-TREND-0, respectively. Effect modifications were observed by sex and age on the association between MDD and MetS. Particularly, younger females (20-49 years) with MDD were more often affected by MetS than younger females without MDD: OR=2.21 (95% CI=1.39-3.50). This association vanished in elderly participants (50-82 years).Conclusion: The data suggest that especially younger (presumably pre-menopausal) females with MDD are more likely to have MetS than those without major depressive disorders, and that age extenuates this association.
C1 [Block, Andrea; Van der Auwera, Sandra; Freyberger, Harald Juergen; Grabe, Hans Joergen] Univ Med Greifswald, Dept Psychiat & Psychotherapy, Ellernholzstr 1-2, D-17475 Greifswald, Germany.
   [Schipf, Sabine; Voelzke, Henry] Univ Med Greifswald, Inst Community Med, Greifswald, Germany.
   [Hannemann, Anke; Nauck, Matthias; Wallaschofski, Henri] Univ Med Greifswald, Inst Clin Chem & Lab Med, Greifswald, Germany.
   [John, Ulrich] Univ Med Greifswald, Inst Epidemiol & Social Med, Greifswald, Germany.
   [Freyberger, Harald Juergen; Grabe, Hans Joergen] Helios Hosp Stralsund, Dept Psychiat & Psychotherapy, Stralsund, Germany.
   [Doerr, Marcus; Felix, Stephan] Univ Med Greifswald, Dept Internal Med B, Greifswald, Germany.
   [Doerr, Marcus; Felix, Stephan] DZHK German Ctr Cardiovasc Res, Partner Site Greifswald, Greifswald, Germany.
   [Zygmunt, Marek] Univ Med Greifswald, Dept Obstet & Gynaecol, Greifswald, Germany.
C3 Universitat Greifswald; Greifswald Medical School; Universitat
   Greifswald; Greifswald Medical School; Universitat Greifswald;
   Greifswald Medical School; Universitat Greifswald; Greifswald Medical
   School; Universitat Greifswald; Greifswald Medical School; German Centre
   for Cardiovascular Research; Universitat Greifswald; Greifswald Medical
   School
RP Block, A (corresponding author), Univ Med Greifswald, Dept Psychiat & Psychotherapy, Ellernholzstr 1-2, D-17475 Greifswald, Germany.
EM andrea.schulz@uni-greifswald.de
RI Dörr, Marcus/F-1919-2010
OI Dorr, Marcus/0000-0001-7471-475X; John, Ulrich/0000-0003-0587-5298;
   Block, Andrea/0000-0002-4819-2529
FU Federal Ministry of Education and Research [01ZZ9603, 01ZZ0103,
   01ZZ0403]; Ministry of Cultural Affairs; Social Ministry of the Federal
   State of Mecklenburg-West Pomerania; Federal Ministry of Education and
   Research (GANI_MED) [03IS2061A]; German Research Foundation [DFG: GR
   1912/5-1]; German Federal Ministry of Education and Research (BMBF)
   [01ZX1314E]
FX SHIP is part of the Community Medicine Research net of the University of
   Greifswald, Germany, which is funded by the Federal Ministry of
   Education and Research (Grants no. 01ZZ9603, 01ZZ0103, and 01ZZ0403),
   the Ministry of Cultural Affairs, and the Social Ministry of the Federal
   State of Mecklenburg-West Pomerania. This work was also funded by
   Federal Ministry of Education and Research (GANI_MED; Grant no.
   03IS2061A) and the German Research Foundation (DFG: GR 1912/5-1). Sandra
   Van der Auwera was supported by the German Federal Ministry of Education
   and Research (BMBF) within the framework of the e:Med research and
   funding concept (Integrament; Grant no. 01ZX1314E).
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NR 69
TC 19
Z9 21
U1 0
U2 22
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0803-9488
EI 1502-4725
J9 NORD J PSYCHIAT
JI Nord. J. Psychiatr.
PD NOV
PY 2016
VL 70
IS 8
BP 611
EP 620
DI 10.1080/08039488.2016.1191535
PG 10
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA DX6XZ
UT WOS:000384530700009
PM 27299922
DA 2025-06-11
ER

PT J
AU Lachaux, M
   Soulié, M
   Hamzaoui, M
   Bailly, A
   Nicol, L
   Rémy-Jouet, I
   Renet, S
   Vendeville, C
   Gluais-Dagorn, P
   Hallakou-Bozec, S
   Monteil, C
   Richard, V
   Mulder, P
AF Lachaux, Marianne
   Soulie, Matthieu
   Hamzaoui, Mouad
   Bailly, Anaelle
   Nicol, Lionel
   Remy-Jouet, Isabelle
   Renet, Sylvanie
   Vendeville, Cathy
   Gluais-Dagorn, Pascale
   Hallakou-Bozec, Sophie
   Monteil, Christelle
   Richard, Vincent
   Mulder, Paul
TI Short-and long-term administration of imeglimin counters cardiorenal
   dysfunction in a rat model of metabolic syndrome
SO ENDOCRINOLOGY DIABETES & METABOLISM
LA English
DT Article
DE cardiomyopathy; imeglimin; rat; type-2 diabetes
AB Introduction: Imeglimin, a glucose-lowering agent targeting mitochondrial bioenergetics, decreases reactive oxygen species (ROS) overproduction and improves glucose homeostasis. We investigated whether this is associated with protective effects on metabolic syndrome-related left ventricular (LV) and vascular dysfunctions.
   Methods: We used Zucker fa/fa rats to assess the effects on LV function, LV tissue perfusion, LV oxidative stress and vascular function induced by imeglimin administered orally for 9 or 90 days at a dose of 150 mg/kg twice daily.
   Results: Compared to untreated animals, 9- and 90-day imeglimin treatment decreased LV end-diastolic pressure and LV end-diastolic pressure-volume relation, increased LV tissue perfusion and decreased LV ROS production. Simultaneously, imeglimin restored acetylcholine-mediated coronary relaxation and mesenteric flow-mediated dilation. One hour after imeglimin administration, when glucose plasma levels were not yet modified, imeglimin reduced LV mitochondrial ROS production and improved LV function. Ninety-day imeglimin treatment reduced related LV and kidney fibrosis and improved kidney function.
   Conclusion: In a rat model, mimicking Human metabolic syndrome, imeglimin immediately countered metabolic syndrome-related cardiac diastolic and vascular dysfunction by reducing oxidative stress/increased NO bioavailability and improving myocardial perfusion and after 90-day treatment myocardial and kidney structure, effects that are, at least in part, independent from glucose control.
C1 [Lachaux, Marianne; Bailly, Anaelle; Nicol, Lionel; Remy-Jouet, Isabelle; Renet, Sylvanie; Richard, Vincent; Mulder, Paul] Normandie Univ, UNIROUEN, Inserm U1096, FHU REMOD VHF, Rouen, France.
   [Soulie, Matthieu; Hamzaoui, Mouad; Vendeville, Cathy; Monteil, Christelle] Normandie Univ, UNIROUEN, UNICAEN, ABTE, Rouen, France.
   [Gluais-Dagorn, Pascale; Hallakou-Bozec, Sophie] Poxel SA, Lyon, France.
C3 Institut National de la Sante et de la Recherche Medicale (Inserm);
   Universite de Rouen Normandie; Universite de Caen Normandie; Universite
   de Rouen Normandie
RP Mulder, P (corresponding author), UFR Sante, INSERM U1096, 22 Bd Gambetta, F-76000 Rouen, France.
EM paul.mulder@univ-rouen.fr
RI Monteil, Christelle/ABF-3312-2022; Richard, Vincent/B-1059-2014
OI BAILLY, Anaelle/0000-0001-5421-2760; Monteil,
   Christelle/0000-0002-4981-0800; Richard, Vincent/0000-0003-0590-0158
FU European Fibro-Targets Project [602904]; European Union; Region
   Normandie; Federation Francaise de Cardiologie; poxel Sa;  [BM1301]
FX poxel Sa; European Fibro-Targets Project, Grant/Award Number: (grant
   agreement No. FP7#602904); European Union and the Region Normandie; the
   FP7-funded COST ADMIRE network, Grant/Award Number: (BM1301); Federation
   Francaise de Cardiologie
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NR 44
TC 17
Z9 18
U1 1
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
EI 2398-9238
J9 ENDOCRIN DIAB METAB
JI Endocrinol. Diabetes Metab.
PD JUL
PY 2020
VL 3
IS 3
AR e00128
DI 10.1002/edm2.128
PG 11
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA VM2XW
UT WOS:000993473700004
PM 32704553
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Hayden, MR
AF Hayden, Melvin R. R.
TI Overview and New Insights into the Metabolic Syndrome: Risk Factors and
   Emerging Variables in the Development of Type 2 Diabetes and
   Cerebrocardiovascular Disease
SO MEDICINA-LITHUANIA
LA English
DT Review
DE endothelial dysfunction; exosomes; hyperinsulinemia; hyperglycemia;
   hyperlipidemia; hypertension; insulin resistance; leptin resistance;
   metainflammation; miRNAs
ID ISLET AMYLOID POLYPEPTIDE; NITRIC-OXIDE SYNTHASE; NECROSIS-FACTOR-ALPHA;
   INSULIN-RESISTANCE; CLINICAL ENDOCRINOLOGY; ARTERIAL STIFFNESS; LEPTIN
   RESISTANCE; ADIPOSE-TISSUE; MITOCHONDRIAL DYSFUNCTION; ENDOTHELIAL
   GLYCOCALYX
AB Metabolic syndrome (MetS) is considered a metabolic disorder that has been steadily increasing globally and seems to parallel the increasing prevalence of obesity. It consists of a cluster of risk factors which traditionally includes obesity and hyperlipidemia, hyperinsulinemia, hypertension, and hyperglycemia. These four core risk factors are associated with insulin resistance (IR) and, importantly, the MetS is known to increase the risk for developing cerebrocardiovascular disease and type 2 diabetes mellitus. The MetS had its early origins in IR and syndrome X. It has undergone numerous name changes, with additional risk factors and variables being added over the years; however, it has remained as the MetS worldwide for the past three decades. This overview continues to add novel insights to the MetS and suggests that leptin resistance with hyperleptinemia, aberrant mitochondrial stress and reactive oxygen species (ROS), impaired folate-mediated one-carbon metabolism with hyperhomocysteinemia, vascular stiffening, microalbuminuria, and visceral adipose tissues extracellular vesicle exosomes be added to the list of associated variables. Notably, the role of a dysfunctional and activated endothelium and deficient nitric oxide bioavailability along with a dysfunctional and attenuated endothelial glycocalyx, vascular inflammation, systemic metainflammation, and the important role of ROS and reactive species interactome are discussed. With new insights and knowledge regarding the MetS comes the possibility of new findings through further research.
C1 [Hayden, Melvin R. R.] Univ Missouri, Sch Med, Diabet & Cardiovasc Dis Ctr, Dept Internal Med Endocrinol Diabet & Metab, One Hosp Dr, Columbia, MO 65211 USA.
C3 University of Missouri System; University of Missouri Columbia
RP Hayden, MR (corresponding author), Univ Missouri, Sch Med, Diabet & Cardiovasc Dis Ctr, Dept Internal Med Endocrinol Diabet & Metab, One Hosp Dr, Columbia, MO 65211 USA.
EM mrh29pete@gmail.com
OI Hayden, Melvin/0000-0001-5178-4245
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NR 211
TC 45
Z9 48
U1 3
U2 9
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1010-660X
EI 1648-9144
J9 MEDICINA-LITHUANIA
JI Med. Lith.
PD MAR
PY 2023
VL 59
IS 3
AR 561
DI 10.3390/medicina59030561
PG 46
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA C1XY2
UT WOS:000959941300001
PM 36984562
OA Green Submitted, gold, Green Published
DA 2025-06-11
ER

PT J
AU Rengasamy, M
   Silva, SADE
   Spada, M
   Price, RB
AF Rengasamy, Manivel
   Da Costa e Silva, Sophia Arruda
   Spada, Meredith
   Price, Rebecca B.
TI Does the moderator matter? Identification of multiple moderators of the
   association between peripheral inflammatory markers and depression
   severity in a large racially diverse community cohort
SO NEUROPSYCHOPHARMACOLOGY
LA English
DT Article
ID C-REACTIVE PROTEIN; SOCIOECONOMIC-STATUS; METABOLIC SYNDROME; STRESS;
   METAANALYSIS; IL-6; RACE; CRP
AB Depressive symptomology has been linked to low-grade peripheral inflammatory markers (PIMs), specifically C-reactive protein (CRP) and white blood cell count (WBC). However, such associations may be affected by multiple moderators (including race/ethnicity), though few well-powered and racially diverse studies have examined this. We examined 31 moderators of PIM-depression relationships in a large racially diverse cohort (n = 21,570). We also examined if associations between PIM and depression severity were dependent on clinical cutpoints for moderate depressive symptoms and elevated CRP. We found several positive moderators of PIM-depression relationships for both WBC and CRP: ongoing medication use (antidepressant, statin, or any prescription drug), presence of sleep concerns, and poor health status (beta's = 0.06-0.21, p's < 0.05). For both WBC and CRP, individuals of non-Hispanic White race/ethnicity were found to have stronger PIM-depression associations overall relative to minoritized groups (B's = 0.14 to 1.01, p's < 0.05). For CRP, stronger PIM-depression relationships existed for individuals with moderate (or greater) depression severity or elevated CRP (B's = 0.27 to 0.49, p's < 0.05). Thus, a wide range of moderators appears to affect PIM-depression associations. These results could help identify participants with strong coupling of PIM-depression severity, to guide future research and personalized treatments for depression and to indicate gaps in the applicability of widely referenced theoretical models among racial/ethnic minoritized groups.
C1 [Rengasamy, Manivel; Da Costa e Silva, Sophia Arruda; Spada, Meredith; Price, Rebecca B.] Univ Pittsburgh, Dept Psychiat, Pittsburgh, PA 15260 USA.
   [Price, Rebecca B.] Univ Pittsburgh, Dept Psychol, Pittsburgh, PA 15260 USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE); University
   of Pittsburgh; Pennsylvania Commonwealth System of Higher Education
   (PCSHE); University of Pittsburgh
RP Rengasamy, M (corresponding author), Univ Pittsburgh, Dept Psychiat, Pittsburgh, PA 15260 USA.
EM rengasamym@upmc.edu
RI Price, Rebecca/AAZ-1198-2021
OI Price, Rebecca/0000-0002-7590-4325
FU Ruth L. Kirschstein National Research Service Award Institutional
   Research Training Grants - National Institutes of Health [NIH T32
   MH018951]
FX This research was supported by funding from the Ruth L. Kirschstein
   National Research Service Award Institutional Research Training Grants
   sponsored by the National Institutes of Health (Grant No. NIH T32
   MH018951: Brent).
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NR 43
TC 8
Z9 8
U1 2
U2 4
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0893-133X
EI 1740-634X
J9 NEUROPSYCHOPHARMACOL
JI Neuropsychopharmacology
PD AUG
PY 2022
VL 47
IS 9
BP 1693
EP 1701
DI 10.1038/s41386-022-01341-1
EA MAY 2022
PG 9
WC Neurosciences; Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA 2X9AK
UT WOS:000799523200001
PM 35595844
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Abdelazeem, AH
   Abuelsaad, ASA
   Abdel-Moniem, A
   Abdel-Gabbar, M
AF Abdelazeem, Ahmed H.
   Abuelsaad, Abdelaziz S. A.
   Abdel-Moniem, Adel
   Abdel-Gabbar, Mohammed
TI Association of metabolic syndrome components with alterations in
   oxidative stress and cytokines expression
SO JOURNAL OF TAIBAH UNIVERSITY FOR SCIENCE
LA English
DT Article
DE Metabolic syndrome; hyperlipidemia; obesity; hypertension;
   hyperglycemia; cytokines; oxidative stress
ID NF-KAPPA-B; INFLAMMATORY CYTOKINES; VASCULAR ENDOTHELIUM;
   INSULIN-RESISTANCE; GENE-EXPRESSION; RISK-FACTORS; OBESITY;
   INTERLEUKIN-8; HYPERTENSION; CELLS
AB Metabolic syndrome (MetS) has been associated with a chronic inflammation state; the specific causative etiology to the MetS will need further investigation. The present study aims to explore the levels and roles of pro- and anti-inflammatory biomarkers and antioxidant enzymes in MetS development. Subjects were divided into five groups: healthy controls; patients with dyslipidemia; patients with dyslipidemia and obesity; patients with dyslipidemia, obesity, and hypertension; patients with dyslipidemia, obesity, hypertension, and hyperglycemia. Antioxidant enzyme activities were dramatically decreased in MetS patients, whereas inflammatory marker levels were elevated. The levels of interleukin (IL)-8, IL-23, IL-33, nuclear factor kappa B (NF-kappa B), resistin, and nitric oxide were positively correlated to triglyceride, low-density lipoprotein-cholesterol, fasting plasma glucose, and glycosylated hemoglobin levels. Therefore, the data indicate that antioxidant enzymes, IL-8, IL-23, IL-33, NF-kappa B, and resistin might be used as tools to ameliorate and treat metabolic diseases.
C1 [Abdelazeem, Ahmed H.; Abdel-Gabbar, Mohammed] Beni Suef Univ, Biochem Dept Fac Sci, Bani Suwayf, Egypt.
   [Abuelsaad, Abdelaziz S. A.] Beni Suef Univ, Fac Sci, Zool Dept, Immunol Div, Bani Suwayf 62511, Egypt.
   [Abdel-Moniem, Adel] Beni Suef Univ, Fac Sci, Zool Dept, Mol Physiol Div, Bani Suwayf, Egypt.
C3 Egyptian Knowledge Bank (EKB); Beni Suef University; Egyptian Knowledge
   Bank (EKB); Beni Suef University; Egyptian Knowledge Bank (EKB); Beni
   Suef University
RP Abuelsaad, ASA (corresponding author), Beni Suef Univ, Fac Sci, Zool Dept, Immunol Div, Bani Suwayf 62511, Egypt.
EM elsaad1@yahoo.com
RI Abuelsaad, Abdelaziz/IYS-8598-2023; Abdelazeem, Ahmed/KUC-9791-2024;
   Abdel gabbar, Mohammed/F-2684-2018
OI Abdelazeem, Ahmed/0000-0002-0599-3393; Abdel gabbar,
   Mohammed/0000-0001-6573-2411; abuelsaad, abdelaziz/0000-0001-8244-9124
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NR 73
TC 7
Z9 7
U1 0
U2 7
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1658-3655
J9 J TAIBAH UNIV SCI
JI J. Taibah Univ. Sci.
PD JAN 1
PY 2021
VL 15
IS 1
BP 928
EP 940
DI 10.1080/16583655.2021.2009680
PG 13
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA XM7BO
UT WOS:000728977900001
OA gold
DA 2025-06-11
ER

PT J
AU Moreno, C
   Nuevo, R
   Chatterji, S
   Verdes, E
   Arango, C
   Ayuso-Mateos, JL
AF Moreno, Carmen
   Nuevo, Roberto
   Chatterji, Somnath
   Verdes, Emese
   Arango, Celso
   Luis Ayuso-Mateos, Jose
TI Psychotic symptoms are associated with physical health problems
   independently of a mental disorder diagnosis: results from the WHO World
   Health Survey
SO WORLD PSYCHIATRY
LA English
DT Article
DE Psychotic symptoms; physical health; medical conditions; access to
   health care; multinational study
ID METABOLIC SYNDROME; GENERAL-PRACTICE; SCHIZOPHRENIA; RISK; PREVALENCE;
   MORTALITY; ILLNESS; DISEASES; IMPACT; CARE
AB This study explored whether physical health problems are related to psychotic symptoms independently of a mental disorder diagnosis. A total of 224,254 subjects recruited for the World Health Organization World Health Survey were subdivided into those with both a lifetime diagnosis of psychosis and at least one psychotic symptom in the 12 months prior to the evaluation, those with at least one psychotic symptom in the past 12 months but no lifetime diagnosis of psychosis, and those without psychotic symptoms in the past 12 months and without a lifetime diagnosis of psychosis. The three groups were compared for the presence of medical conditions, health problems, and access to health care. Medical conditions and health problems (angina, asthma, arthritis, tuberculosis, vision or hearing problems, mouth/teeth problems, alcohol consumption, smoking, and accidents), medication consumption, and hospital admissions (but not regular health care visits) were more frequent in individuals with psychotic symptoms but no psychosis diagnosis, compared to those with no symptoms and no diagnosis. The number of medical conditions increased with the number of psychotic symptoms. Given the sample analyzed, this trend seems to be independent from the socio-economic development of the country or the specific health care system.
C1 [Moreno, Carmen; Arango, Celso] Hosp Gen Univ Gregorio Maranon, Child & Adolescent Psychiat Dept, IiSGM, CIBERSAM, Madrid, Spain.
   [Nuevo, Roberto; Luis Ayuso-Mateos, Jose] Univ Autonoma Madrid, Hosp Univ Pricesa, CIBERSAM, Dept Psychiat, Madrid, Spain.
   [Chatterji, Somnath; Verdes, Emese] World Hlth Org, Dept Hlth Stat & Informat, Geneva, Switzerland.
C3 CIBER - Centro de Investigacion Biomedica en Red; CIBERSAM; General
   University Gregorio Maranon Hospital; CIBER - Centro de Investigacion
   Biomedica en Red; CIBERSAM; Autonomous University of Madrid; World
   Health Organization
RP Moreno, C (corresponding author), Hosp Gen Univ Gregorio Maranon, Child & Adolescent Psychiat Dept, IiSGM, CIBERSAM, Madrid, Spain.
RI CHATTERJI, Somnath/ABE-6832-2020; Nuevo, Roberto/AAE-9849-2020; Moreno,
   Carmen/AAQ-1079-2021; Arango, Celso/H-6433-2015
OI Ayuso-Mateos, Jose Luis/0000-0002-7544-826X; Nuevo,
   Roberto/0000-0003-3385-2747; Moreno, Carmen/0000-0003-0541-4846; Arango,
   Celso/0000-0003-3382-4754
FU Spanish Ministry of Economy and Competitiveness; Instituto de Salud
   Carlos III; CIBERSAM; Madrid Regional Government [S2010/BMD-2422 AGES];
   European Union; Fundacion Alicia Koplowitz; Fundacion Mutua Madrilena;
   ERA-NET NEURON (Network of European Funding for Neuroscience Research);
   World Health Organization
FX This work was supported by the Spanish Ministry of Economy and
   Competitiveness, Instituto de Salud Carlos III, CIBERSAM, Madrid
   Regional Government (S2010/BMD-2422 AGES), European Union Structural
   Funds, Fundacion Alicia Koplowitz, Fundacion Mutua Madrilena, ERA-NET
   NEURON (Network of European Funding for Neuroscience Research) and the
   World Health Organization.
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NR 60
TC 92
Z9 96
U1 0
U2 20
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1723-8617
EI 2051-5545
J9 WORLD PSYCHIATRY
JI World Psychiatry
PD OCT
PY 2013
VL 12
IS 3
BP 251
EP 257
DI 10.1002/wps.20070
PG 7
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 229KU
UT WOS:000325264000018
PM 24096791
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Yaman, SO
   Yucesan, FB
   Orem, A
   Orem, C
   Kural, BV
   Yaman, H
AF Yaman, Serap Ozer
   Yucesan, Fulya Balaban
   Orem, Asim
   Orem, Cihan
   Kural, Birgul Vanizor
   Yaman, Huseyin
TI An increased disulfide/native thiol ratio and oxidative stress index in
   metabolic syndrome patients with postprandial lipemia
SO INTERNATIONAL JOURNAL OF DIABETES IN DEVELOPING COUNTRIES
LA English
DT Article
DE Metabolic syndrome; Postprandial lipemia; Thiol; disulfide homeostasis;
   Oxidative stress
ID THIOL/DISULFIDE HOMEOSTASIS; CARDIOVASCULAR-DISEASE; LIPOPROTEINS;
   ASSOCIATION
AB Background Metabolic syndrome (MetS) is closely related to lipid disorders and increased oxidant stress, and is associated with cardiovascular diseases. Objective The purpose of this research was to examine thiol/disulfide homeostasis and oxidative stress in MetS patients with postprandial lipemia (PPL) during fasting by considering time-dependent changes in the postprandial period. Methods Twenty-five patients with MetS and 25 healthy controls underwent a 6-h oral fat tolerance test. Dynamic thiol/disulfide homeostasis (native thiol, disulfide, and total thiol) values and total oxidant status (TOS), total antioxidant status (TAS), and Oxidative Stress Index (OSI): (TOS/TAS) were evaluated. Results Increased levels of disulfide, and higher disulfide/native thiol ratio, TOS, and OSI values were observed at fasting and in the postprandial period in MetS compared to the control group, peaking at the 4(th) hour in both groups (p < 0.05). ROC analysis showed that both fasting and 4(th) hour disulfide/native thiol ratios exhibited the highest values. Higher disulfide/native thiol ratio values were observed at the 4(th) hour and higher OSI in the 2(nd) hour in the upper tertiles for MetS (p < 0.05). Conclusions An increased disulfide/native thiol ratio and OSI level elevation in MetS may be closely associated with PPL. The disulfide/native thiol ratio in MetS subjects with PPL may play a role for evaluating oxidative stress, especially in postprandial 4(th) hour.
C1 [Yaman, Serap Ozer; Yucesan, Fulya Balaban; Orem, Asim; Kural, Birgul Vanizor; Yaman, Huseyin] Karadeniz Tech Univ, Fac Med, Dept Med Biochem, TR-61080 Trabzon, Turkey.
   [Orem, Cihan] Karadeniz Tech Univ, Fac Med, Dept Cardiol, TR-61080 Trabzon, Turkey.
C3 Karadeniz Technical University; Karadeniz Technical University
RP Yaman, SO (corresponding author), Karadeniz Tech Univ, Fac Med, Dept Med Biochem, TR-61080 Trabzon, Turkey.
EM serapozer@ktu.edu.tr; fulyablb@yahoo.com; aorem64@yahoo.com;
   corem71@yahoo.com; bvanizorkural@hotmail.com; huseyinyaman28@gmail.com
RI Yaman, Huseyin/AAW-7002-2020; Örem, Asım/AAK-9785-2020
OI VANIZOR KURAL, Birgul/0000-0003-0730-9660; BALABAN YUCESAN,
   Fulya/0000-0002-9854-4721; OZER YAMAN, SERAP/0000-0002-5089-0836; Yaman,
   Huseyin/0000-0003-4440-3912
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NR 38
TC 2
Z9 2
U1 0
U2 7
PU SPRINGER INDIA
PI NEW DELHI
PA 7TH FLOOR, VIJAYA BUILDING, 17, BARAKHAMBA ROAD, NEW DELHI, 110 001,
   INDIA
SN 0973-3930
EI 1998-3832
J9 INT J DIABETES DEV C
JI Int. Diabetes Dev. Ctries.
PD FEB
PY 2023
VL 43
IS 1
BP 125
EP 133
DI 10.1007/s13410-022-01095-y
EA JUN 2022
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA A2GK6
UT WOS:000810855500003
DA 2025-06-11
ER

PT J
AU Sáenz-Medina, J
   Jorge, E
   Corbacho, C
   Santos, M
   Sánchez, A
   Soblechero, P
   Virumbrales, E
   Ramil, E
   Coronado, MJ
   Castillón, I
   Prieto, D
   Carballido, J
AF Saenz-Medina, Javier
   Jorge, E.
   Corbacho, C.
   Santos, M.
   Sanchez, A.
   Soblechero, P.
   Virumbrales, E.
   Ramil, E.
   Coronado, M. J.
   Castillon, I.
   Prieto, D.
   Carballido, J.
TI Metabolic syndrome contributes to renal injury mediated by hyperoxaluria
   in a murine model of nephrolithiasis
SO UROLITHIASIS
LA English
DT Article
DE Metabolic syndrome; Oxidative stress; Renal stone; Hyperoxaluria
ID FRENCH POPULATION; KIDNEY-STONES; RAT KIDNEYS; ASSOCIATION;
   HYPERTENSION; DEPOSITION
AB Metabolic syndrome (MS) individuals have a higher risk of developing chronic kidney disease through unclear pathogenic mechanisms. MS has been also related with higher nephrolithiasis prevalence. To establish the influence of MS on renal function, we designed a murine model of combined metabolic syndrome and hyperoxaluria. Four groups of male Sprague-Dawley rats were established: (1) control group (n = 10) fed with standard chow; (2) stone former group (SF) (n = 10) fed with standard chow plus 0.75% ethylene glycol administered in the drinking water; (3) metabolic syndrome group (MS) (n = 10), fed with 60% fructose diet; (4) metabolic syndrome + stone former group (MS + SF) (n = 10), 60% fructose diet and 0.75% EG in the drinking water. MS group showed a significant injury to renal function when hyperoxaluria was induced. It was demonstrated by a significant decrease of creatinine clearance (p < 0.001), with higher tubular damage (34.3%, CI 95% 23.9-44.7, p < 0.001), produced by deposition of crystals, and increased tubular synthesis of osteopontin as a response to tubular damage. Induction of hyperoxaluria in rats with MS causes severe morphological alterations with a significant impairment of renal function. This impairment is not produced in rats without MS. Therefore, this model can be useful for the study of the influence of MS in stone formation.
C1 [Saenz-Medina, Javier; Castillon, I.; Carballido, J.] Hosp Univ Puerta Hierro Majadahonda, Dept Urol, C Lope de Vega 2,Portal 5 1 B, Madrid 28223, Spain.
   [Jorge, E.; Soblechero, P.; Virumbrales, E.] Hosp Univ Puerta Hierro Majadahonda, Dept Clin Biochem, Madrid, Spain.
   [Corbacho, C.] Hosp Univ Puerta Hierro Majadahonda, Dept Pathol, Madrid, Spain.
   [Santos, M.] Inst Invest Sanitaria Puerta Hierro, Med & Surg Res Facil, Madrid, Spain.
   [Sanchez, A.] Inst Invest Sanitaria Puerta Hierro, Biobank, Madrid, Spain.
   [Ramil, E.] Inst Invest Sanitaria Puerta Hierro, Mol Biol & DNA Sequencing Facil, Madrid, Spain.
   [Coronado, M. J.] Inst Invest Sanitaria Puerta Hierro, Confocal Microscopy Facil, Madrid, Spain.
   [Prieto, D.] Univ Complutense Madrid, Fac Farm, Dept Anim Phisiol, Madrid, Spain.
C3 Hospital Puerta de Hierro-Majadahonda; Hospital Puerta de
   Hierro-Majadahonda; Hospital Puerta de Hierro-Majadahonda; Hospital
   Puerta de Hierro-Majadahonda; Hospital Puerta de Hierro-Majadahonda;
   Hospital Puerta de Hierro-Majadahonda; Hospital Puerta de
   Hierro-Majadahonda; Complutense University of Madrid
RP Sáenz-Medina, J (corresponding author), Hosp Univ Puerta Hierro Majadahonda, Dept Urol, C Lope de Vega 2,Portal 5 1 B, Madrid 28223, Spain.
EM javiersaenzmedina@yahoo.es
RI Coronado, Maria/AAB-2112-2019; Sánchez-López, Antonio/E-3037-2018;
   Santos, Martín/AAM-7198-2021; Ramil Tojeiro, Elvira/AAB-2476-2019;
   Carballido Rodriguez, Joaquin/G-2347-2018; Saenz Medina,
   Javier/E-9391-2016; PRIETO, DOLORES/S-8172-2018
OI Ramil Tojeiro, Elvira/0000-0003-0785-3826; Coronado Albi, Maria
   Jose/0000-0003-0281-3366; Carballido Rodriguez,
   Joaquin/0000-0002-3701-7514; Santos, Martin/0000-0002-5928-6010; Saenz
   Medina, Javier/0000-0002-8568-854X; Sanchez Lopez, Antonio
   Jose/0000-0001-7168-6175; PRIETO, DOLORES/0000-0001-7049-5991
FU Urological Society from Madrid; Astellas Pharma Espana
FX Urological Society from Madrid. Research Grant 2013 and Astellas Pharma
   Espana are acknowledged.
CR [Anonymous], B ACAD NATL MED
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NR 22
TC 8
Z9 8
U1 0
U2 6
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 2194-7228
EI 2194-7236
J9 UROLITHIASIS
JI Urolithiasis
PD APR
PY 2018
VL 46
IS 2
BP 179
EP 186
DI 10.1007/s00240-017-0979-9
PG 8
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA FZ4TL
UT WOS:000427584700007
PM 28405703
DA 2025-06-11
ER

PT J
AU Bascou, A
   Savall, F
   Vergnault, M
   Montoriol, R
   Guilbeau-Frugier, C
   Maupoint, E
   El Khal, MC
   Telmon, N
AF Bascou, Agathe
   Savall, Frederic
   Vergnault, Marion
   Montoriol, Romain
   Guilbeau-Frugier, Celine
   Maupoint, Estelle
   El Khal, Mohamed Cherif
   Telmon, Norbert
TI Finding of Hyperostosis Frontalis Interna During the Autopsy Procedure:
   Forensic Issues
SO JOURNAL OF FORENSIC SCIENCES
LA English
DT Article
DE forensic science; hyperostosis frontalis interna; forensic pathology;
   Morgagni-Stewart-Morel syndrome; psychiatric disorder; metabolic
   syndrome
ID DEFINITION; PATIENT
AB Hyperostosis frontalis interna is a common phenomenon, which may have been overrated in its significance in the past, and may, currently be underrated in its significance. We present three cases of hyperostosis frontalis interna found during medicolegal autopsies and discuss their forensic considerations. The patients were all middle-aged women with metabolic and endocrine manifestations and psychiatric ailments; thickening of the inner table of the frontal bone of the skull was found during each autopsy. We describe the relationship between hyperostosis frontalis interna, metabolic manifestations, and neuropsychiatric symptoms as part of Morgagni-Stewart-Morel syndrome. There is still considerable disagreement in the scientific community as to whether this syndrome is a clinical entity. Nonetheless, awareness of Morgagni-Stewart-Morel syndrome can be of help in understanding the circumstances surrounding death. In some other cases, hyperostosis frontalis interna could be used by forensic pathologists as criteria for sexing and aging a skeleton.
C1 [Bascou, Agathe; Savall, Frederic; Vergnault, Marion; Montoriol, Romain; Guilbeau-Frugier, Celine; Telmon, Norbert] Ctr Hosp Univ Rangueil, Serv Med Legale, Ave Prof Jean Poulhes, F-31059 Toulouse 9, France.
   [Maupoint, Estelle] Ctr Hosp Univ Rangueil, Serv Radiol, Ave Prof Jean Poulhes, F-31059 Toulouse 9, France.
   [El Khal, Mohamed Cherif] Ctr Hosp Univ Farhat Hachcd, Serv Med Legale, Rue Ibn Jazzar, Sousse 4031, Tunisia.
C3 CHU de Toulouse; CHU de Toulouse
RP Bascou, A (corresponding author), Ctr Hosp Univ Rangueil, Serv Med Legale, Ave Prof Jean Poulhes, F-31059 Toulouse 9, France.
EM agathe.bascou@gmail.com
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NR 34
TC 3
Z9 4
U1 0
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-1198
EI 1556-4029
J9 J FORENSIC SCI
JI J. Forensic Sci.
PD NOV
PY 2019
VL 64
IS 6
BP 1929
EP 1932
DI 10.1111/1556-4029.14100
PG 4
WC Medicine, Legal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Legal Medicine
GA JU2CI
UT WOS:000501482700045
PM 31162647
DA 2025-06-11
ER

PT J
AU Jin, SM
   Hong, YJ
   Jee, JH
   Bae, JC
   Hur, KY
   Lee, MK
   Kim, JH
AF Jin, Sang-Man
   Hong, Yong Joo
   Jee, Jae Hwan
   Bae, Ji Cheol
   Hur, Kyu Yeon
   Lee, Moon-Kyu
   Kim, Jae Hyeon
TI Change in serum albumin concentration is inversely and independently
   associated with risk of incident metabolic syndrome
SO METABOLISM-CLINICAL AND EXPERIMENTAL
LA English
DT Article
DE Albumin; Change; Metabolic syndrome
ID CORONARY-HEART-DISEASE; ACUTE-PHASE PROTEINS; ALL-CAUSE MORTALITY;
   INSULIN-RESISTANCE; CARDIOVASCULAR-DISEASE; OXIDATIVE STRESS;
   INFLAMMATION; PREDICTOR; ATHEROSCLEROSIS; INDIVIDUALS
AB Background. Low serum albumin concentration is associated with a high risk of morbidity and mortality from cardiovascular diseases. However, high serum albumin level appears to be linked to metabolic syndrome (MetS). This study aimed to dissect the relative contributions of baseline and change in serum albumin concentration to the risk of incident metabolic syndrome.
   Methods. This was a 5-year (63,060 person-years) retrospective longitudinal study of 12,567 participants without metabolic syndrome, diabetes, or cardiovascular disease who were enrolled in a health screening program. The risk of developing MetS was analyzed according to baseline and change in serum albumin concentration.
   Results. A total of 2582 incident cases of metabolic syndrome developed. The hazard ratio (HR) for incident MetS increased with increasing quartile of baseline serum albumin level compared with those in the lowest quartile, in a fully adjusted model (p for trend = 0.013). The HRs [95% confidence intervals (CIs)] of incident MetS comparing the second, third, and fourth quartiles to the first quartile of change in serum albumin level were 0.478 (0.421-0.544), 0.353 (0.307-0.405), and 0.262 (0.224-0.305) in the fully adjusted model, respectively (p for trend <0.001). Percent change in serum albumin concentration inversely correlated with percent change in serum level of high-sensitivity C-reactive protein (r = -3.5444, p < 0.001).
   Conclusions. Although a higher baseline level of serum albumin was linked to increased risk of incident metabolic syndrome, increase in serum albumin concentration might be a protective factor against the risk of MetS. (C) 2016 Elsevier Inc. All rights reserved.
C1 [Jin, Sang-Man; Hong, Yong Joo; Hur, Kyu Yeon; Lee, Moon-Kyu; Kim, Jae Hyeon] Sungkyunkwan Univ, Sch Med, Div Endocrinol & Metab, Dept Med,Samsung Med Ctr, 81 Irwon Ro, Seoul 135710, South Korea.
   [Jee, Jae Hwan] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Hlth Promot Ctr, Seoul, South Korea.
   [Bae, Ji Cheol] Sungkyunkwan Univ, Sch Med, Div Endocrinol & Metab, Dept Med,Samsung Changwon Hosp, Chang Won, South Korea.
   [Kim, Jae Hyeon] Sungkyunkwan Univ, Dept Clin Res Design & Evaluat, SAIHST, Seoul, South Korea.
C3 Sungkyunkwan University (SKKU); Samsung Medical Center; Sungkyunkwan
   University (SKKU); Samsung Medical Center; Sungkyunkwan University
   (SKKU); Samsung Medical Center; Sungkyunkwan University (SKKU)
RP Kim, JH (corresponding author), Samsung Med Ctr, Div Endocrinol & Metab, Seoul 135710, South Korea.
EM jaehyeon@skku.edu
RI Jin, Sang-Man/AFO-5933-2022
OI Jin, Sang-Man/0000-0001-5929-3627
CR Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
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NR 29
TC 29
Z9 32
U1 0
U2 7
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0026-0495
EI 1532-8600
J9 METABOLISM
JI Metab.-Clin. Exp.
PD NOV
PY 2016
VL 65
IS 11
BP 1629
EP 1635
DI 10.1016/j.metabol.2016.08.006
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA DZ6TB
UT WOS:000385993700006
PM 27733251
DA 2025-06-11
ER

PT J
AU Anfossi, G
   Russo, I
   Trovati, M
AF Anfossi, Giovanni
   Russo, Isabella
   Trovati, Mariella
TI Resistance to Aspirin and Thienopyridines in Diabetes Mellitus and
   Metabolic Syndrome
SO CURRENT VASCULAR PHARMACOLOGY
LA English
DT Review
DE Aspirin; cardiovascular disease; clopidogrel; metabolic syndrome; nitric
   oxide; obesity; platelets; thienopyridines; ticlopidine; type 2 diabetes
   mellitus
ID LOW-DOSE ASPIRIN; CORONARY-ARTERY-DISEASE; PERSISTENT PLATELET
   ACTIVATION; CARDIOVASCULAR-DISEASE; PRIMARY PREVENTION; CLOPIDOGREL
   RESISTANCE; MYOCARDIAL-INFARCTION; ANTIPLATELET THERAPY;
   INSULIN-RESISTANCE; OXIDATIVE STRESS
AB Platelets from patients affected by diabetes mellitus and metabolic syndrome show an impaired sensitivity to physiological antiaggregating agents and an enhanced activation state, mirrored by an increased expression of membrane activation markers; furthermore, they are more prone to form spontaneous microaggregates with ADP receptor involvement. These abnormalities are responsible for a pro-thrombotic condition, contributing to a high cardiovascular risk.
   This pattern of platelet abnormalities provides a strong rationale for aggressive antiplatelet therapy strongly recommended by guidelines both in diabetes mellitus and in metabolic syndrome, not only in the setting of acute coronary syndromes, but also for the long-term prevention of the cardiovascular events.
   Antiplatelet therapy in these pathological conditions, however, is still a matter of intense debate, especially because a high prevalence of "resistance" to these drugs (and to aspirin in particular) has been described in these patients. This may result in non-significant reductions in cardiovascular events.
   Different factors seem to be involved, including: i) genetic polymorphisms; ii) hyperglycemia and poor metabolic control; iii) reduced sensitivity to nitric oxide; iv) a pro-inflammatory and/ or pro-thrombotic status, and, v) increased oxidative stress.
   This review will take into consideration: i) the results of the most relevant studies addressing the effects of the antiaggregating treatment in patients affected by diabetes mellitus and/ or metabolic syndrome, and, ii) the biochemical mechanisms accounting for the impaired sensitivity to aspirin and thienopyridines in the above mentioned clinical conditions.
C1 [Anfossi, Giovanni; Russo, Isabella; Trovati, Mariella] Univ Turin, San Luigi Gonzaga Hosp, Dept Clin & Biol Sci, Diabet Unit, I-10043 Turin, Italy.
C3 University of Turin; Azienda Ospedaliero-Universitaria San Luigi Gonzaga
RP Anfossi, G (corresponding author), Univ Turin, San Luigi Gonzaga Hosp, Dept Clin & Biol Sci, Diabet Unit, I-10043 Turin, Italy.
EM giovanni.anfossi@unito.it
RI Russo, Isabella/AAC-5779-2020
OI Russo, Isabella/0000-0002-2921-1763; TROVATI,
   MARIELLA/0000-0003-4397-8060
FU Italian Ministero dell'Istruzione; Universita e Ricerca (MIUR)
FX This study was supported by a grant from Regione Piemonte to Prof.
   Giovanni Anfossi for studies on insulin resistance in patients with
   metabolic syndrome and by a grant from Italian Ministero
   dell'Istruzione, Universita e Ricerca (MIUR) COFIN 2004 within the
   project "The molecular basis of insulin resistance and their importance
   in the pathogenesis of the alterations of the vessel wall", Local
   Coordinator: Prof. Giovanni Anfossi, National Coordinator: Prof. Amalia
   Bosia.
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NR 243
TC 32
Z9 37
U1 0
U2 2
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1570-1611
EI 1875-6212
J9 CURR VASC PHARMACOL
JI Current Vascular Pharmacology
PD OCT
PY 2008
VL 6
IS 4
BP 313
EP 328
DI 10.2174/157016108785909760
PG 16
WC Pharmacology & Pharmacy; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Cardiovascular System & Cardiology
GA 360KY
UT WOS:000260057600009
PM 18855719
DA 2025-06-11
ER

PT J
AU Silveira, JQ
   Dourado, GKZS
   Cesar, TB
AF Silveira, Jacqueline Q.
   Dourado, Grace K. Z. S.
   Cesar, Thais B.
TI Red-fleshed sweet orange juice improves the risk factors for metabolic
   syndrome
SO INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION
LA English
DT Article
DE Abdominal obesity; citrus flavonoids; flavanones; insulin resistance;
   oxidative stress; red orange juice
ID ENDOTHELIAL FUNCTION; INSULIN-RESISTANCE; ABDOMINAL OBESITY;
   APOLIPOPROTEIN-B; VITAMIN-C; CITRUS; BLOOD; CHOLESTEROL; CONSUMPTION;
   MARKERS
AB Orange juice consumption can promote lower levels of oxidative stress and inflammation due to the antioxidant activity of citrus flavonoids and carotenoids. In addition, red-fleshed sweet orange juice (red orange juice) also contains lycopene. This study investigated the effects of red orange juice consumption on risk factors for metabolic syndrome. Volunteers consumed red orange juice daily for 8 weeks, with clinical and biochemical assessments performed at baseline and on the final day. There was no change in the abdominal obesity, but low-density lipoprotein cholesterol, C-reactive protein decreased, while there was an increase of the antioxidant activity in serum after red orange juice consumption. Insulin resistance and systolic blood pressure were reduced in normal-weight volunteers, while diastolic blood pressure decreased in overweight volunteers after intervention. Red orange juice showed anti-inflammatory, antioxidant, and lipid-lowering properties that may prevent the development of metabolic syndrome.
C1 [Silveira, Jacqueline Q.; Dourado, Grace K. Z. S.; Cesar, Thais B.] Univ Estadual Paulista, UNESP, Sch Pharmaceut Sci, Dept Food & Nutr,Lab Nutr, Rodovia Araraquara Jau,Km 1, Araraquara, SP, Brazil.
C3 Universidade Estadual Paulista
RP Cesar, TB (corresponding author), Univ Estadual Paulista, UNESP, Sch Pharmaceut Sci, Dept Food & Nutr,Lab Nutr, Rodovia Araraquara Jau,Km 1, Araraquara, SP, Brazil.
EM tcesar@fcfar.unesp.br
RI Cesar, Thais/T-6110-2019; Cesar, Thais/I-4540-2013
OI Cesar, Thais/0000-0001-7878-7075
FU Brazilian agency CNPq
FX The authors are grateful to the Brazilian agency CNPq for grant of
   scholarship to Jacqueline Q. Silveira, to Citrosuco S/A (Brazil) for
   supplying red orange juices for this study, and Claudia G Lima for the
   assistance in the data collection.
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   Yamamoto M, 2008, J NUTR SCI VITAMINOL, V54, P95, DOI 10.3177/jnsv.54.95
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   Yoshida M, 2007, J NUTR, V137, P2121, DOI 10.1093/jn/137.9.2121
NR 59
TC 51
Z9 52
U1 0
U2 25
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0963-7486
EI 1465-3478
J9 INT J FOOD SCI NUTR
JI Int. J. Food Sci. Nutr.
PY 2015
VL 66
IS 7
BP 830
EP 836
DI 10.3109/09637486.2015.1093610
PG 7
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA DD4LA
UT WOS:000369893200016
PM 26471075
DA 2025-06-11
ER

PT J
AU Gulati, S
   Misra, A
   Pandey, RM
   Bhatt, SP
   Saluja, S
AF Gulati, Seema
   Misra, Anoop
   Pandey, Ravindra Mohan
   Bhatt, Surya Prakash
   Saluja, Shelza
TI Effects of pistachio nuts on body composition, metabolic, inflammatory
   and oxidative stress parameters in Asian Indians with metabolic
   syndrome: A 24-wk, randomized control trial
SO NUTRITION
LA English
DT Article
DE Metabolic syndrome; Pistachio nut
ID CORONARY-HEART-DISEASE; ABDOMINAL ADIPOSE-TISSUE; C-REACTIVE PROTEIN;
   INSULIN-RESISTANCE; RISK-FACTORS; CONSUMPTION; OBESITY; WEIGHT; SERUM;
   FAT
AB Objective: The aim of this study was to evaluate the effects of pistachio nuts as an adjunct to diet and exercise on body composition, metabolic, inflammatory, and oxidative stress parameters in Asian Indians with metabolic syndrome.
   Methods: In this 24-wk randomized control trial, 60 individuals with the metabolic syndrome were randomized to either pistachio (intervention group) or control group (diet as per weight and physical activity profile, modulated according to dietary guidelines for Asian Indians) after 3 wk of a diet and exercise run in. In the first group, unsalted pistachios (20% energy) were given daily. A standard diet and exercise protocol was followed for both groups. Body weight, waist circumference (WC), magnetic resonance imaging estimation of intraabdominal adipose tissue and subcutaneous abdominal adipose tissue, fasting blood glucose (FBG), fasting serum insulin, glycosylated hemoglobin, lipid profile, high-sensitivity C-reactive protein (hs-CRP), adiponectin, free fatty acids (FFAs), tumor necrosis factor (TNF)-alpha, leptin, and thiobarbituric acid reactive substances (TBARS) were assessed before and after the intervention.
   Results: Statistically significant improvement in mean values for various parameters in the intervention group compared with control group were as follows: WC (P < 0.02), FBG (P < 0.04), total cholesterol (P < 0.02), low-density lipoprotein cholesterol (P < 0.006), hs-CRP (P < 0.05), TNF-alpha (P <0.03), FFAs (P < 0.001), TBARS (P < 0.01), and adiponectin levels (P < 0.001).
   Conclusion: A single food intervention with pistachios leads to beneficial effects on the cardiometabolic profile of Asian Indians with metabolic syndrome. (C) 2014 Elsevier Inc. All rights reserved.
C1 [Gulati, Seema; Misra, Anoop; Saluja, Shelza] SDA, Diabet Fdn India, New Delhi, India.
   [Gulati, Seema; Misra, Anoop; Saluja, Shelza] SDA, Natl Diabet Obes & Cholesterol Fdn NDOC, New Delhi, India.
   [Gulati, Seema; Misra, Anoop; Saluja, Shelza] SDA, Ctr Nutr & Metab Res CNET, New Delhi, India.
   [Misra, Anoop] Fortis C DOC Ctr Excellence Diabet Metab Dis & En, New Delhi, India.
   [Misra, Anoop] Fortis Flt Lt Rajan Dhall Hosp, New Delhi, India.
   [Pandey, Ravindra Mohan; Bhatt, Surya Prakash] AIIMS, New Delhi, India.
C3 All India Institute of Medical Sciences (AIIMS) New Delhi
RP Misra, A (corresponding author), SDA, Diabet Fdn India, New Delhi, India.
EM anoopmisra@metabolicresearchindia.com
RI Bhatt, Surya/K-5263-2019; Bhatt, Dr. Surya P/X-5941-2018
OI Bhatt, Dr. Surya P/0000-0001-9489-9747; Bhatt, Surya/0000-0002-8418-4497
FU Paramount Farms Inc., California, USA
FX This study was fully supported by grant from the Paramount Farms Inc.,
   California, USA. We acknowledge Dr. Mark Dreher for his valuable
   comments. We are thankful to all the participants of the study for their
   cooperation.
CR Abate N, 2004, J CLIN ENDOCR METAB, V89, P2750, DOI 10.1210/jc.2003-031843
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NR 38
TC 122
Z9 129
U1 0
U2 29
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0899-9007
EI 1873-1244
J9 NUTRITION
JI Nutrition
PD FEB
PY 2014
VL 30
IS 2
BP 192
EP 197
DI 10.1016/j.nut.2013.08.005
PG 6
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 293BZ
UT WOS:000329947700011
PM 24377454
DA 2025-06-11
ER

PT J
AU Lachaux, M
   Barrera-Chimal, J
   Nicol, L
   Réemy-Jouet, I
   Renet, S
   Dumesnil, A
   Wecker, D
   Richard, V
   Kolkhof, P
   Jaisser, F
   Ouvrard-Pascaud, A
   Mulder, P
AF Lachaux, Marianne
   Barrera-Chimal, Jonatan
   Nicol, Lionel
   Remy-Jouet, Isabelle
   Renet, Sylvanie
   Dumesnil, Anais
   Wecker, Didier
   Richard, Vincent
   Kolkhof, Peter
   Jaisser, Frederic
   Ouvrard-Pascaud, Antoine
   Mulder, Paul
TI Short- and long-term administration of the non-steroidal
   mineralocorticoid receptor antagonist finerenone opposes metabolic
   syndrome-related cardio-renal dysfunction
SO DIABETES OBESITY & METABOLISM
LA English
DT Article
DE animal pharmacology; cardiovascular disease; diabetes complications;
   drug development; experimental pharmacology; type 2 diabetes
ID LEFT-VENTRICULAR DYSFUNCTION; FAILING DIABETIC HEART; OXIDATIVE STRESS;
   NITRIC-OXIDE; ENDOTHELIAL DYSFUNCTION; CONTRACTILE DYSFUNCTION;
   DIASTOLIC FUNCTION; FEMALE RATS; ALDOSTERONE; MORTALITY
AB Aim: To determine whether non-steroidal mineralocorticoid receptor (MR) antagonists oppose metabolic syndrome-related end-organ, i.e. cardiac, damage.
   Materials and methods: In Zucker fa/fa rats, a rat model of metabolic syndrome, we assessed the effects of the non-steroidal MR antagonist finerenone (oral 2 mg/kg/day) on left ventricular (LV) function, haemodynamics and remodelling (using echocardiography, magnetic resonance imaging and biochemical methods).
   Results: Long-term (90 days) finerenone modified neither systolic blood pressure nor heart rate, but reduced LV end-diastolic pressure and LV end-diastolic pressure-volume relationship, without modifying LV end-systolic pressure and LV end-systolic pressure-volume relationship. Simultaneously, long-term finerenone reduced both LV systolic and diastolic diameters, associated with reductions in LV weight and LV collagen density, while proteinuria and renal nGAL expression were reduced. Short-term (7 days) finerenone improved LV haemodynamics and reduced LV systolic diameter, without modifying LV diastolic diameter. Moreover, short-term finerenone increased myocardial tissue perfusion and reduced myocardial reactive oxygen species, while plasma nitrite levels, an indicator of nitric oxide (NO) bio-availability, were increased.
   Conclusions: In rats with metabolic syndrome, the non-steroidal MR antagonist finerenone opposed metabolic syndrome-related diastolic cardiac dysfunction and nephropathy. This involved acute effects, such as improved myocardial perfusion, reduced oxidative stress/increased NO bioavailability, as well as long-term effects, such as modifications in the myocardial structure.
C1 [Lachaux, Marianne; Nicol, Lionel; Remy-Jouet, Isabelle; Renet, Sylvanie; Dumesnil, Anais; Richard, Vincent; Ouvrard-Pascaud, Antoine; Mulder, Paul] Normandie Univ, UNIROUEN, INSERM, FHU REMOD VHF,U1096, F-76000 Rouen, France.
   [Barrera-Chimal, Jonatan; Jaisser, Frederic] INSERM, U1138, Paris, France.
   [Wecker, Didier] Bruker Biospin MRI GmbH, Ettlingen, Germany.
   [Kolkhof, Peter] Bayer AG, Wuppertal, Germany.
C3 Universite de Rouen Normandie; Institut National de la Sante et de la
   Recherche Medicale (Inserm); Universite Paris Cite; Institut National de
   la Sante et de la Recherche Medicale (Inserm); Bruker Corporation;
   Bruker BioSpin GmbH; Bayer AG
RP Mulder, P (corresponding author), INSERM, U1096, UFR Sante, 22 Bd Gambetta, F-76000 Rouen, France.
EM paul.mulder@univ-rouen.fr
RI Kolkhof, Peter/IST-3079-2023; Jaisser, Frederic/P-4287-2017;
   Barrera-Chimal, Jonatan/AAC-1380-2020; Richard, Vincent/B-1059-2014
OI Richard, Vincent/0000-0003-0590-0158; Mulder, Paul/0000-0002-5936-5704;
   Barrera-Chimal, JONATAN/0000-0002-0711-5092
FU Bayer AG Germany; European Union; Region Normandie (European Regional
   Development Fund); European Fibro-Targets Project (FP7) [602904]; FP7
   [BM1301]; FRM grant
FX This work was funded by a research grant from Bayer AG Germany and
   co-supported by the European Union and the Region Normandie (European
   Regional Development Fund), the European Fibro-Targets Project (grant
   agreement No. FP7#602904), and the FP7-funded COST ADMIRE network
   (BM1301). J.B.-C. was a recipient of the FRM grant.
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NR 62
TC 41
Z9 42
U1 0
U2 17
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1462-8902
EI 1463-1326
J9 DIABETES OBES METAB
JI Diabetes Obes. Metab.
PD OCT
PY 2018
VL 20
IS 10
BP 2399
EP 2407
DI 10.1111/dom.13393
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA GT0ZU
UT WOS:000444185800009
PM 29862614
DA 2025-06-11
ER

PT J
AU Schvey, NA
   Shank, LM
   Tanofsky-Kraff, M
   Ramirez, S
   Altman, DR
   Swanson, T
   Rubin, AG
   Kelly, NR
   LeMay-Russell, S
   Byrne, ME
   Parker, MN
   Broadney, MM
   Brady, SM
   Yanovski, SZ
   Yanovski, JA
AF Schvey, Natasha A.
   Shank, Lisa M.
   Tanofsky-Kraff, Marian
   Ramirez, Sophie
   Altman, Deborah R.
   Swanson, Taylor
   Rubin, Alex G.
   Kelly, Nichole R.
   LeMay-Russell, Sarah
   Byrne, Meghan E.
   Parker, Megan N.
   Broadney, Miranda M.
   Brady, Sheila M.
   Yanovski, Susan Z.
   Yanovski, Jack A.
TI Weight-basedteasing in youth: Associations with metabolic and
   inflammatory markers
SO PEDIATRIC OBESITY
LA English
DT Article
DE adolescents; children; inflammation; metabolic syndrome; weight-based
   teasing
ID TEASING SCALE POTS; C-REACTIVE PROTEIN; BODY-FAT; INSULIN-RESISTANCE;
   OXIDATIVE STRESS; PEDIATRIC LOSS; DISCRIMINATION; ADOLESCENTS; OBESITY;
   STIGMA
AB Background Research among adults suggests that weight stigma is associated with worsened cardiometabolic health. However, these relationships have not been examined among youth. Objective Assess associations between weight-based teasing (WBT) and metabolic and inflammatory markers among two samples of youth: (1) a non-treatment-seeking sample and (2) a weight loss treatment-seeking sample with obesity. Method Weight, height, adiposity, waist circumference and blood pressure were measured. Fasting blood samples were collected for metabolic (triglycerides, glucose, high-density lipoprotein cholesterol) and inflammatory analytes (high-sensitivity C-reactive protein in Study 1 and erythrocyte sedimentation rate in both studies). Youths completed the Perception of Teasing Scale, a measure of WBT. Metabolic and inflammatory indices were compared between those with and without teasing, adjusting for demographics and body composition. Results Study 1 enrolled 201 non-treatment-seeking youth (M-age= 13.1y; 54.2% female; 44.8% non-Hispanic White; 32.8% with overweight/obesity); 15.4% reported WBT. Study 2 enrolled 111 treatment-seeking adolescents with obesity (M-age= 14.0y; 66.7% female; 37.8% non-Hispanic White); 73.0% reported WBT. Adjusting for covariates, WBT was not associated with cardiometabolic risk factors in either study. Conclusions WBT was not associated with worsened cardiometabolic health. Longitudinal research is needed to elucidate associations between WBT and health in youth.
C1 [Schvey, Natasha A.; Tanofsky-Kraff, Marian; LeMay-Russell, Sarah; Byrne, Meghan E.; Parker, Megan N.] Uniformed Serv Univ Hlth Sci USUHS, Med & Clin Psychol Dept, Bethesda, MD USA.
   [Schvey, Natasha A.; Shank, Lisa M.; Tanofsky-Kraff, Marian; Ramirez, Sophie; Altman, Deborah R.; Swanson, Taylor; Rubin, Alex G.; LeMay-Russell, Sarah; Byrne, Meghan E.; Parker, Megan N.; Broadney, Miranda M.; Brady, Sheila M.; Yanovski, Susan Z.; Yanovski, Jack A.] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Sect Growth & Obes, Div Intramural Res, NIH, Bethesda, MD USA.
   [Shank, Lisa M.; Tanofsky-Kraff, Marian] Uniformed Serv Univ Hlth Sci USUHS, Dept Med, Mil Cardiovasc Outcomes Res MiCOR Program, Bethesda, MD USA.
   [Shank, Lisa M.] Metis Fdn, San Antonio, TX USA.
   [Kelly, Nichole R.] 5207 Univ Oregon, Dept Counseling Psychol & Human Serv & Prevent Sc, Coll Educ, Eugene, OR USA.
   [Yanovski, Susan Z.] NIDDK, Off Obes Res, Div Digest Dis & Nutr, NIH, Bethesda, MD 20892 USA.
C3 National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver
   National Institute of Child Health & Human Development (NICHD); Division
   of Intramural Research (DIR); University of Oregon; National Institutes
   of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive &
   Kidney Diseases (NIDDK)
RP Schvey, NA (corresponding author), USU, Dept Med & Clin Psychol, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA.
EM natasha.schvey@usuhs.edu
RI ; Shank, Lisa/I-7079-2015
OI Kelly, Nichole/0000-0003-0812-4182; Tanofsky-Kraff,
   Marian/0000-0003-3871-2233; Yanovski, Jack/0000-0001-8542-1637; Shank,
   Lisa/0000-0002-6922-7946; Rubin, Alex/0000-0003-4338-5396; Byrne,
   Meghan/0000-0002-4745-649X
FU Eunice Kennedy Shriver National Institute of Child Health and Human
   Development [Z1A-HD00641]
FX Eunice Kennedy Shriver National Institute of Child Health and Human
   Development, Grant/Award Number: Z1A-HD00641
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NR 53
TC 3
Z9 4
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2047-6310
EI 2047-6302
J9 PEDIATR OBES
JI Pediatr. Obes.
PD MAR
PY 2021
VL 16
IS 3
AR e12729
DI 10.1111/ijpo.12729
EA OCT 2020
PG 9
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Pediatrics
GA QG2YX
UT WOS:000578268200001
PM 33059389
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Abo-Youssef, AM
AF Abo-Youssef, Amira M.
TI Protective effect of rosiglitazone, quercetin, and their combination on
   fructose-induced metabolic syndrome in rats
SO INDIAN JOURNAL OF PHARMACOLOGY
LA English
DT Article
DE Fructose enriched diet; metabolic syndrome; oxidative stress; quercetin;
   rosiglitazone
ID INSULIN SENSITIVITY; OXIDATIVE STRESS; RENAL-DISEASE; URIC-ACID; DIET;
   HYPERTENSION; RESISTANCE; GLUCOSE; WISTAR; MODEL
AB Objectives: Quercetin exhibits a wide range of biological functions. The present study aimed to investigate the possible beneficial effects of rosiglitazone, quercetin as well as their combination on metabolic and biochemical changes associated with the fructose-induced metabolic syndrome (MS).
   Materials and Methods: Four groups of rats were fed on fructose-enriched diet for 14 weeks. One group served as fructose-enriched diet control, while the remaining groups were treated with rosiglitazone (4 mg/kg/day), quercetin (50 mg/kg/day), and their combination during the last 4 weeks. A fifth group was fed on normal laboratory diet. At the end of the experiment, blood samples were withdrawn for the estimation of markers of MS.
   Results: Rosiglitazone or quercetin attenuated the biochemical and metabolic changes associated with MS. The combination of rosiglitazone and quercetin nearly normalized these changes.
   Conclusion: Quercetin, as well as its combination with rosiglitazone, showed beneficial protective effects against metabolic and biochemical changes associated with MS.
C1 [Abo-Youssef, Amira M.] Beni Suef Univ, Fac Pharm, Dept Pharmacol & Toxicol, Bani Suwayf, Egypt.
C3 Egyptian Knowledge Bank (EKB); Beni Suef University
RP Abo-Youssef, AM (corresponding author), Beni Suef Univ, Fac Pharm, Dept Pharmacol & Toxicol, Bani Suwayf, Egypt.
EM amira.abouyousif@pharm.bsu.edu.eg
OI Abo-Youssef, Amira/0000-0001-8419-6095
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NR 29
TC 9
Z9 10
U1 0
U2 7
PU MEDKNOW PUBLICATIONS & MEDIA PVT LTD
PI MUMBAI
PA B-9, KANARA BUSINESS CENTRE, OFF LINK RD, GHAKTOPAR-E, MUMBAI, 400075,
   INDIA
SN 0253-7613
EI 1998-3751
J9 INDIAN J PHARMACOL
JI Indian J. Pharmacol.
PD NOV-DEC
PY 2015
VL 47
IS 6
BP 620
EP 626
DI 10.4103/0253-7613.169577
PG 7
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA CX4UK
UT WOS:000365695600008
PM 26729953
OA Green Published
DA 2025-06-11
ER

PT J
AU Krajnak, K
   Waugh, S
   Johnson, C
   Miller, R
   Kiedrowski, M
AF Krajnak, Kristine
   Waugh, Stacey
   Johnson, Claud
   Miller, Roger
   Kiedrowski, Megan
TI Vibration Disrupts Vascular Function in a Model of Metabolic Syndrome
SO INDUSTRIAL HEALTH
LA English
DT Article
DE Vibration-induced white finger; Zucker rats; Obesity; Endothelial
   function; Reactive oxygen species; Nitric oxide
ID NITRIC-OXIDE SYNTHASE; STRESS; RAT; PEROXYNITRITE; DYSFUNCTION;
   INDUCTION; FREQUENCY; DILATION; CALCIUM; ARTERY
AB Vibration-induced white finger (VWF) is a disorder seen in workers exposed to hand-transmitted vibration, and is characterized by cold-induced vasospasms and ringer blanching. Because overweight people with metabolic syndrome are pre-disposed to developing peripheral vascular disorders, it has been suggested that they also may be at greater risk of developing VWF if exposed to occupational vibration. We used an animal model of metabolic syndrome, the obese Zucker rat, to determine if metabolic syndrome alters vascular responses to vibration. Tails of lean and obese Zucker rats were exposed to vibration (125 Hz, 49 m/s(2) r.m.s.) or control conditions for 4 h/d for 10 d. Ventral tail arteries were collected and assessed for changes in gene expression, levels of reactive oxygen species (ROS) and for responsiveness to vasomodulating factors. Vibration exposure generally reduced the sensitivity of arteries to acetylcholine (ACh)-induced vasodilation. This decrease in sensitivity was most apparent in obese rats. Vibration also induced reductions in vascular nitric oxide concentrations and increases in vascular concentrations of ROS in obese rats. These results indicate that vibration interferes with endothelial-mediated vasodilation, and that metabolic syndrome exacerbates these effects. These findings are consistent with idea that workers with metabolic syndrome have an increased risk of developing VWF.
C1 [Krajnak, Kristine; Waugh, Stacey; Johnson, Claud; Miller, Roger; Kiedrowski, Megan] NIOSH, Engn & Controls Technol Branch, Morgantown, WV 26505 USA.
   [Kiedrowski, Megan] Univ Iowa, Dept Microbiol, Iowa City, IA 52242 USA.
C3 Centers for Disease Control & Prevention - USA; National Institute for
   Occupational Safety & Health (NIOSH); University of Iowa
RP Krajnak, K (corresponding author), NIOSH, Engn & Controls Technol Branch, 1095 Willowdale Rd, Morgantown, WV 26505 USA.
EM kkrajnak@cdc.gov
OI Kiedrowski, Megan/0000-0003-4610-182X
CR [Anonymous], 2001, Mechanical VibrationMeasurement and Evaluation of Human Exposure to Hand-Transmitted VibrationPart 1: General Requirements
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NR 37
TC 24
Z9 24
U1 0
U2 2
PU NATL INST OCCUPATIONAL SAFETY & HEALTH, JAPAN
PI KAWASAKI KANAGAWA
PA 21-1 NAGAO 6-CHOME TAMA-KU, KAWASAKI KANAGAWA, 214, JAPAN
SN 0019-8366
EI 1880-8026
J9 IND HEALTH
JI Ind. Health
PD SEP
PY 2009
VL 47
IS 5
SI SI
BP 533
EP 542
DI 10.2486/indhealth.47.533
PG 10
WC Environmental Sciences; Public, Environmental & Occupational Health;
   Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health; Toxicology
GA 501HO
UT WOS:000270372400011
PM 19834263
OA Bronze
DA 2025-06-11
ER

PT J
AU Petrova, A
   Simeonova, R
   Voycheva, C
   Savov, Y
   Marinov, L
   Balabanova, V
   Gevrenova, R
   Zheleva-Dimitrova, D
AF Petrova, Alexandra
   Simeonova, Rumyana
   Voycheva, Christina
   Savov, Yonko
   Marinov, Lyubomir
   Balabanova, Vessela
   Gevrenova, Reneta
   Zheleva-Dimitrova, Dimitrina
TI Metabolic syndrome: comparison of three diet-induced experimental models
SO PHARMACIA
LA English
DT Article
DE Metabolic syndrome; high-fat diets; cafeteria diet; rat model
ID OXIDATIVE STRESS; INSULIN-RESISTANCE; BLOOD-PRESSURE; OBESITY; WOMEN;
   DEFINITION; MEN
AB The high-fat (HF) diets can be used to generate a valid rodent model for metabolic syndrome (METS). The aim of this study was to compare three different diets, namely a high-fat, high-carbohydrate diet (HF-HCD), a high-fat lard-based diet (HFD), and a cafeteria diet (CFD), in terms of the ability to induce METS. The next step was to characterize the syndrome according to the biochemical and histopathological changes in the liver and pancreas, and to determine the optimal animal model. As a result, all diets disturbed significantly the serum biochemical parameters. HF-HCD and CFD increased the uric acid levels and reduced the weight gain in comparison with the standard chow diet (SCD) and HFD. The HFD and CFD induced the highest fasting glycemia levels. Although the animals fed with HF-HCD had the lowest body weight, the most serious histopathological changes in the pancreas, hypertension, and oxidative stress were noted in them.
C1 [Petrova, Alexandra; Simeonova, Rumyana; Marinov, Lyubomir] Med Univ Sofia, Dept Pharmacol Pharmacotherapy & Toxicol, Fac Pharm, Sofia 1000, Bulgaria.
   [Voycheva, Christina] Med Univ Sofia, Dept Pharmaceut Technol Biopharm, Fac Pharm, Sofia 1000, Bulgaria.
   [Savov, Yonko] Inst Emergency Med NI Pirogov, Bul Totleben 21, Sofia, Bulgaria.
   [Balabanova, Vessela; Gevrenova, Reneta; Zheleva-Dimitrova, Dimitrina] Med Univ Sofia, Dept Pharmacognosy, Fac Pharm, Sofia 1000, Bulgaria.
C3 Medical University Sofia; Medical University Sofia; Medical University
   Sofia
RP Zheleva-Dimitrova, D (corresponding author), Med Univ Sofia, Dept Pharmacognosy, Fac Pharm, Sofia 1000, Bulgaria.
EM dzheleva@pharmfac.mu-sofia.bg
RI Gevrenova, Reneta/AEA-8791-2022; Simeonova, Vitanska,
   Rumyana/G-8002-2019; VOYCHEVA, Christina/AAY-2504-2020; Balabanova,
   Vessela/AAV-6720-2021; Zheleva-Dimitrova, Dimitrina/GQI-1010-2022;
   Marinov, Lyubomir/AAW-2055-2021
FU Medical Science Council at the Medical University-Sofia, Bulgaria
   [4405/04.07.2022]
FX The study was supported by Contract (sic)-321/19.12.2022, Project No
   4405/04.07.2022 from the Medical Science Council at the Medical
   University-Sofia, Bulgaria.
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NR 41
TC 2
Z9 2
U1 0
U2 1
PU PENSOFT PUBLISHERS
PI SOFIA
PA 12 PROF GEORGI ZLATARSKI ST, SOFIA, 1700, BULGARIA
SN 0428-0296
EI 2603-557X
J9 PHARMACIA
JI Pharmacia
PD DEC 12
PY 2023
VL 70
IS 4
BP 1539
EP 1548
DI 10.3897/pharmacia.70.e109965
PG 10
WC Pharmacology & Pharmacy
WE Emerging Sources Citation Index (ESCI)
SC Pharmacology & Pharmacy
GA IA0K7
UT WOS:001163478500003
OA gold
DA 2025-06-11
ER

PT J
AU Bell, C
AF Bell, Christopher
TI Pigment Epithelium-Derived Factor: A Not So Sympathetic Regulator of
   Insulin Resistance?
SO EXERCISE AND SPORT SCIENCES REVIEWS
LA English
DT Review
DE metabolic syndrome; oxidative stress; inflammation; angiogenesis;
   metabolic flexibility; adipose triglyceride lipase; sympathetic nervous
   system
ID ADRENERGIC-RECEPTOR REGULATION; THERMOGENIC RESPONSE; METABOLIC
   SYNDROME; SKELETAL-MUSCLE; SERUM-LEVELS; FACTOR PEDF; HEALTHY;
   IDENTIFICATION; SENSITIVITY; EXPRESSION
AB BELL, C. Pigment epithelium-derived factor: a not so sympathetic regulator of insulin resistance? Exerc. Sport Sci. Rev., Vol. 39, No. 4, pp. 187-190, 2011. Pigment epithelium-derived factor (PEDF), an adipokine, is a regulator of oxidative stress, inflammation, angiogenesis, and insulin sensitivity. Contrary to animal and cell culture data, inhibition of the sympathoadrenal system does not affect serum PEDF in humans. However, during acute beta-adrenergic receptor stimulation serum PEDF concentration is decreased. PEDF may be involved in cross talk between adipose tissue and skeletal muscle.
C1 Colorado State Univ, Dept Hlth & Exercise Sci, Ft Collins, CO 80523 USA.
C3 Colorado State University System; Colorado State University Fort Collins
RP Bell, C (corresponding author), Colorado State Univ, Dept Hlth & Exercise Sci, Ft Collins, CO 80523 USA.
EM christopher.bell@colostate.edu
OI Bell, Christopher/0000-0002-7706-0912
FU American Diabetes Association; Defense Advanced Research Projects
   Agency; Office of Naval Research
FX The author receives funding from the American Diabetes Association's
   Amaranth Diabetes Fund, Defense Advanced Research Projects Agency, and
   Office of Naval Research. The work of other researchers is recognized;
   regretfully, the reference limitations imposed by Exercise and Sport
   Sciences Reviews prevent the inclusion of these citations.
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NR 35
TC 10
Z9 11
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0091-6331
EI 1538-3008
J9 EXERC SPORT SCI REV
JI Exerc. Sport Sci. Rev.
PD OCT
PY 2011
VL 39
IS 4
BP 187
EP 190
DI 10.1097/JES.0b013e31822673f0
PG 4
WC Physiology; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology; Sport Sciences
GA 823XJ
UT WOS:000295161000004
PM 21697716
OA Bronze
DA 2025-06-11
ER

PT J
AU Amin, SN
   Shaltout, SA
   El Gazzar, WB
   Latif, NSA
   Al-jussani, GN
   Alabdallat, YJ
   Albakri, KA
   Elberry, DA
AF Amin, Shaimaa Nasr
   Shaltout, Sherif Ahmed
   El Gazzar, Walaa Bayoumie
   Latif, Noha Samir Abdel
   Al-jussani, Ghadah Nazar
   Alabdallat, Yasmeen Jamal
   Albakri, Khaled Anwer
   Elberry, Dalia Azmy
TI Impact of NMDA receptors block versus GABA-A receptors modulation on
   synaptic plasticity and brain electrical activity in metabolic syndrome
SO ADVANCES IN MEDICAL SCIENCES
LA English
DT Article
DE Metabolic syndrome; NMDAR; GABA-A; EEG; Cognition
ID ROSTRAL VENTROLATERAL MEDULLA; C-REACTIVE PROTEIN; REDUCED METABOLITES;
   COGNITIVE FUNCTIONS; INSULIN-RESISTANCE; SPECTRAL-ANALYSIS;
   BLOOD-PRESSURE; ANIMAL-MODEL; MOUSE MODEL; IN-VITRO
AB Purpose: Metabolic syndrome (MetS) is a common disorder associated with disturbed neurotransmitter homeostasis. Memantine, an N-methyl-D-aspartate receptor (NMDAR) antagonist, was first used in Alzheimer's disease. Allopregnanolone (Allo), a potent positive allosteric modulator of the Gamma-Amino-Butyric Acid (GABA)-A receptors, decreases in neurodegenerative diseases. The study investigated the impact of Memantine versus Allo administration on the animal model of MetS to clarify whether the mechanism of abnormalities is related more to excitatory or inhibitory neurotransmitter dysfunction. Materials and methods: Fifty-six male rats were allocated into 7 groups: 4 control groups, 1 MetS group, and 2 treated MetS groups. They underwent assessment of cognition-related behavior by open field and forced swimming tests, electroencephalogram (EEG) recording, serum markers confirming the establishment of MetS model and hippocampal Glial Fibrillary Acidic Protein (GFAP) and Brain-Derived Neurotrophic Factor (BDNF). Results: Allo improved anxiety-like behavior and decreased grooming frequency compared to Memantine. Both drugs increased GFAP and BDNF expression, improving synaptic plasticity and cognition-related behaviors. The therapeutic effect of Allo was more beneficial regarding lipid profile and anxiety. We reported progressive slowing of EEG waves in the MetS group with Memantine and Allo treatment with increased relative theta and decreased relative delta rhythms. Conclusions: Both Allo and Memantine boosted the outcome parameters in the animal model of MetS. Allo markedly improved the anxiety-like behavior in the form of significantly decreased grooming frequency compared to the Memantine-treated groups. Both drugs were associated with increased hippocampal GFAP and BDNF expression, indicating an improvement in synaptic plasticity and so, cognition-related behaviors.
C1 [Amin, Shaimaa Nasr; El Gazzar, Walaa Bayoumie] Hashemite Univ, Fac Med, Dept Anat Physiol & Biochem, POB 330127, Zarqa 13133, Jordan.
   [Amin, Shaimaa Nasr; Elberry, Dalia Azmy] Cairo Univ, Fac Med, Dept Physiol, Cairo, Egypt.
   [Shaltout, Sherif Ahmed] Hashemite Univ, Fac Med, Dept Pharmacol Publ Hlth & Clin Skills, Zarqa, Jordan.
   [Shaltout, Sherif Ahmed] Benha Univ, Fac Med, Dept Pharmacol, Banha, Egypt.
   [El Gazzar, Walaa Bayoumie] Benha Univ, Fac Med, Dept Med Biochem & Mol Biol, Banha, Egypt.
   [Latif, Noha Samir Abdel] Cairo Univ, Fac Med, Dept Med Pharmacol, Cairo, Egypt.
   [Latif, Noha Samir Abdel] Armed Forces Coll Med, Dept Med Pharmacol, Cairo, Egypt.
   [Al-jussani, Ghadah Nazar] Hashemite Univ, Fac Med, Dept Microbiol Pathol & Forens Med, Zarqa, Jordan.
   [Alabdallat, Yasmeen Jamal; Albakri, Khaled Anwer] Hashemite Univ, Fac Med, Zarqa, Jordan.
C3 Hashemite University; Egyptian Knowledge Bank (EKB); Cairo University;
   Hashemite University; Egyptian Knowledge Bank (EKB); Benha University;
   Egyptian Knowledge Bank (EKB); Benha University; Egyptian Knowledge Bank
   (EKB); Cairo University; Armed Forces College of Medicine (AFCM);
   Hashemite University; Hashemite University
RP Amin, SN (corresponding author), Hashemite Univ, Fac Med, Dept Anat Physiol & Biochem, POB 330127, Zarqa 13133, Jordan.
EM shaimaa@hu.edu.jo
RI el gazzar, walaa/KMA-5855-2024; Alabdallat, Yasmeen/AAW-8057-2021; Amin,
   Shaimaa/B-2764-2015
OI el gazzar, walaa/0000-0001-5172-1105; Al-Jussani,
   Ghadah/0000-0002-9345-9093; shaltout, sherif/0000-0001-6501-724X;
   Alabdallat, Yasmeen/0000-0001-6855-3718
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NR 131
TC 0
Z9 0
U1 2
U2 3
PU ELSEVIER URBAN & PARTNER SP Z O O
PI WROCLAW
PA UL MIGDALOWA 4, LOK 59, WROCLAW, 02-796, POLAND
SN 1896-1126
EI 1898-4002
J9 ADV MED SCI-POLAND
JI Adv. Med. Sci.
PD MAR
PY 2024
VL 69
IS 1
BP 176
EP 189
DI 10.1016/j.advms.2024.03.008
EA APR 2024
PG 14
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA QY3L3
UT WOS:001224389400001
PM 38561071
DA 2025-06-11
ER

PT J
AU Dobhal, S
   Singh, MF
   Setya, S
   Bisht, S
AF Dobhal, Swati
   Singh, Mamta F.
   Setya, Sonal
   Bisht, Shradha
TI Comparative Assessment of the Effect of Lemongrass (Cymbopogon
   citratus) Ethanolic Extract, Aqueous Extract and Essential Oil in
   High Fat Diet and Fructose Induced Metabolic Syndrome in Rats
SO INDIAN JOURNAL OF PHARMACEUTICAL EDUCATION AND RESEARCH
LA English
DT Article
DE C-reactive protein; Hyperlipidaemia; Insulin resistance; Lemongrass;
   Metabolic syndrome; Obesity
ID C-REACTIVE PROTEIN; CORONARY-HEART-DISEASE; INSULIN-RESISTANCE;
   OXIDATIVE STRESS; GLUCOSE; ASSAY; LIPOPROTEIN; SYSTEM; ELISA; MODEL
AB Background: Lemongrass (Cymbopogon citratus) is widely used as a folklore medication for treating obesity and diabetes. The present study evaluates the comparative effect of ethanolic and aqueous extract and essential oil of lemongrass on various conditions associated with the metabolic syndrome. Materials and Methods: High fat diet and fructose (20% w/v) were given for 60 days to induce the metabolic syndrome in Wistar rats. Body weight and BMI were assessed weekly and fasting blood sugar was estimated at 15 days interval. Lemongrass ethanolic extract (LGEE) and aqueous extract (LGAE) were prepared and lemongrass oil (LGEO) was extracted. LGEE, LGAE and LGEO were given to the animals for 42 days. Various biochemical, hormonal and tissue parameters were assessed after completion of treatment protocol. Histopathology of pancreas and liver was performed. Results: Phytochemical analysis disseminated that total flavonoid, phenolic and alkaloid content are present in LGEE and LGAE, with maximum level of terpenoids in LGEO. Treatment of HDR with LGEE and LGEO caused significant reduction (p<0.001) while LGAE exhibited moderate reduction (p< 0.01) in the body weight, BMI, and fasting blood sugar. LGEE and LGEO treatment also normalized abnormalities in serum insulin, insulin resistance, leptin, lipid profile and CRP level in hyperlipidaemic diabetic rats. A significant (p<0.001) level of reduction in liver enzymes and improvement in oxidative stress parameters was observed after treatment with LGEE and LGEO. Histopathology showed improved histoarchitecture after treatment. Conclusion: Results concluded that administration of LGEE and LGEO exhibited better protection in conditions associated with metabolic syndrome than LGAE.
C1 [Dobhal, Swati; Singh, Mamta F.] Sardar Bhagwan Singh Univ, Sch Pharmaceut Sci & Technol, Dehra Dun, Uttarakhand, India.
   [Setya, Sonal] SGT Univ, SGT Coll Pharm, Gurugram, Haryana, India.
   [Bisht, Shradha] Babu Banarasi Northern India Inst Technol, Fac Pharm, Lucknow, Uttar Pradesh, India.
RP Singh, MF (corresponding author), SBS Univ, Sch Pharmaceut Sci & Technol, Dehra Dun, Uttarakhand, India.
EM mamta_fr2002@yahoo.co.in
RI Bisht, Shradha/AAB-6518-2021
OI Bisht, Shradha/0000-0001-7500-766X; F Singh, Mamta/0000-0001-7367-8371;
   Dobhal, Swati/0000-0002-5252-6675
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NR 48
TC 3
Z9 3
U1 0
U2 2
PU ASSOC PHARMACEUTICAL TEACHERS INDIA
PI BANGALORE
PA AL-AMEEN COLL PHARMACY, OPP LALBACH MAIN GATE, HOSUR MAIN RD, BANGALORE,
   560 027, INDIA
SN 0019-5464
J9 INDIAN J PHARM EDUC
JI Indian J. Pharm. Educ. Res.
PD APR-JUN
PY 2022
VL 56
IS 2
SU S
BP S281
EP S293
DI 10.5530/ijper.56.2s.99
PG 13
WC Education, Scientific Disciplines; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Education & Educational Research; Pharmacology & Pharmacy
GA 1S4YO
UT WOS:000804057800017
OA hybrid
DA 2025-06-11
ER

PT J
AU Li, L
   Xiong, L
   Liu, ZH
   Zhang, L
AF Li, Lu
   Xiong, Ling
   Liu, Zhihua
   Zhang, Lin
TI Metabolic syndrome patterns by gender in major depressive disorder
SO PLOS ONE
LA English
DT Article
ID PREVALENCE; ANXIETY; EPIDEMIOLOGY; ASSOCIATION; MORTALITY; SYMPTOMS;
   DISEASE; HEALTH; CHINA
AB Major depressive disorder (MDD) and metabolic syndrome (MetS) are significant health challenges, with distinct gender-specific manifestations. This suggests that the clinical presentation of MetS within the MDD cohort may also vary by gender. The objective of this study is to explore these gender-specific clinical patterns in the co-occurrence of MetS among hospitalized MDD patients, thereby offering insights and guidance for targeted interventions aimed at managing MetS in this demographic. The study included 1,281 first hospitalization MDD patients. Data were collected on socio-demographic characteristics and general clinical profiles. Metabolic parameters, routine biochemical markers, and psychological symptoms were measured and analyzed. The prevalence of MetS was 8.21% in male patients and 10.34% in female patients, with no significant difference between genders. Gender-specific risk factors were identified: in males, age and anxiety symptoms were significant predictors of MetS, while in females, age at onset and married were linked to the development of MetS. Additionally, MetS severity was influenced by age at onset in males and by both age at onset and married in females. This study found no gender-specific prevalence of MetS in hospitalized MDD patients. However, gender-specific factors influencing MetS development and severity highlight the need for focused management in older, married females and older males with high anxiety symptoms.
C1 [Li, Lu; Zhang, Lin] Wuhan Mental Hlth Ctr, Dept Psychiat, Wuhan, Peoples R China.
   [Xiong, Ling] Hubei Tradit Chinese Med Univ, Dept Anesthesiol, Affiliated Hosp, Wuhan, Peoples R China.
   [Liu, Zhihua] Fourth Peoples Hosp Nanyang, Dept Psychiat, Nanyang, Henan, Peoples R China.
RP Zhang, L (corresponding author), Wuhan Mental Hlth Ctr, Dept Psychiat, Wuhan, Peoples R China.; Liu, ZH (corresponding author), Fourth Peoples Hosp Nanyang, Dept Psychiat, Nanyang, Henan, Peoples R China.
EM linzhang16@qq.com; zhihua0188@wo.cn
RI LIU, zhihua/AAJ-7144-2020
FU Wuhan Medical Science Research General Project [WZ20Z09]
FX This study was funded by the scientific research project of Wuhan
   Medical Science Research General Project (WZ20Z09 to LX: PI).
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NR 51
TC 1
Z9 1
U1 2
U2 2
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
EI 1932-6203
J9 PLOS ONE
JI PLoS One
PD DEC 4
PY 2024
VL 19
IS 12
AR e0313629
DI 10.1371/journal.pone.0313629
PG 13
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA O7K6I
UT WOS:001372873500035
PM 39630622
OA gold
DA 2025-06-11
ER

PT J
AU Timurkaynak, T
   Balcioglu, S
   Arslan, U
   Kocaman, SA
   Cengel, A
AF Timurkaynak, Timur
   Balcioglu, Serhat
   Arslan, Ugur
   Kocaman, Sinan A.
   Cengel, Atiye
TI Plasma homocysteine level in cardiac syndrome X and its relation with
   duke treadmill score
SO SAUDI MEDICAL JOURNAL
LA English
DT Article
ID CORONARY-ARTERY-DISEASE; RISK-FACTOR; ENDOTHELIAL DYSFUNCTION; METABOLIC
   SYNDROME; VASCULAR-DISEASE; PROGNOSTIC VALUE; ANGIOGRAMS; MORTALITY;
   ANGINA; WOMEN
AB Objective: To investigate the plasma homocysteine level and the relationship between plasma homocysteine level and duke treadmill score (DTS) in cardiac syndrome X (CSX) patients.
   Methods: Seventy-nine patients (36 male, 43 female, mean age: 50 +/- 8.8 years) admitted to Gazi University Hospital, Ankara, Turkey with typical effort angina, positive stress test, and angiographically normal coronary arteries between January and September 2006 were included in this prospective and controlled study. Thirty asymptomatic patients (11 male, 19 female, mean age: 47.6 +/- 8.3 years) with 2 cardiovascular risk factors were chosen as a control group. Plasma homocysteine level was measured in both groups and DTS was calculated in the CSX group. Plasma homocysteine was measured with the AxSYM homocysteine immunoassay method in both groups.
   Results: Plasma homocysteine level was higher in the CSX group compared to the control group (16.5 +/- 4.9 mu mol/L, n=79,versus 12.4 +/- 4.1 mu mol/L, n=30, p<0.001). The DTS was -2.7 +/- 5.3 in the CSX group. There was a negative correlation between the DTS and homocysteine levels in the CSX group. (r=-0.506, p<0.001).
   Conclusion: Plasma homocysteine level, which is known to cause endothelial dysfunction and microvascular ischemia were higher in CSX patients. Also, this increase in homocysteine level inversely correlated with the DTS, which represents the magnitude of ischemia.
C1 [Timurkaynak, Timur; Balcioglu, Serhat; Arslan, Ugur; Kocaman, Sinan A.; Cengel, Atiye] Gazi Univ, Sch Med, Dept Cardiol, TR-06500 Ankara, Turkey.
C3 Gazi University
RP Timurkaynak, T (corresponding author), Gazi Univ, Sch Med, Dept Cardiol, TR-06500 Ankara, Turkey.
EM ttimurkaynak@gmail.com
RI Arslan, Ugur/F-4993-2014
OI Arslan, Ugur/0000-0001-8572-3571
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NR 26
TC 6
Z9 7
U1 0
U2 2
PU SAUDI MED J
PI RIYADH
PA ARMED FORCES HOSPITAL, PO BOX 7897,, RIYADH 11159, SAUDI ARABIA
SN 0379-5284
J9 SAUDI MED J
JI Saudi Med. J.
PD MAR
PY 2008
VL 29
IS 3
BP 364
EP 367
PG 4
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 284KB
UT WOS:000254704200006
PM 18327360
DA 2025-06-11
ER

PT J
AU Gomes, SL
   Bobby, Z
   Ganesan, P
   Saroja, K
   Parameswari, GR
AF Gomes, Slanda Litty
   Bobby, Zachariah
   Ganesan, Prasanth
   Saroja, Kovvuri
   Parameswari, G. Renuka
TI Metabolic syndrome and its related biochemical derangements in breast
   cancer patients who received neoadjuvant chemotherapy: A study from a
   tertiary care oncology centre from Puducherry, South India
SO DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS
LA English
DT Article
DE Metabolic syndrome; Triple negative breast cancer; Type 2 diabetes
   mellitus
ID CARDIOVASCULAR-DISEASE; DIABETES-MELLITUS; INSULIN; RISK; OBESITY
AB Background and aims: Comparison of the existence of metabolic syndrome, its components and their related biochemical complications between newly diagnosed and treated breast cancer patients.
   Methods: Forty newly diagnosed untreated breast cancer patients and forty breast cancer patients who had received 7 cycles of neoadjuvant chemotherapy were recruited as group 1 and group 2 respectively. Height, weight, blood pressure, hormonal status, and tumor size were noted. The fasting blood glucose and lipid profile were estimated in AU 5811 Beckman coulter Clinical chemistry analyzer. Fasting insulin was estimated using Beckman Coulter access immunoassay system (UnicelDxI600). HbA1c assay was carried out in HPLC based ion exchange chromatography (Tosoh automated glycohemoglobin analyzer G8. Homeostasis Model Assessment 2-IR (HOMA 2-IR), HOMA-% B and HOMA-% S were calculated using an online calculator HOMA CALCULATOR [Oxford University]. Serum hsCRP and MDA were estimated by ELISA. FRAP assay was carried out manually to measure antioxidant status.
   Results: The existence of metabolic syndrome as well as type 2 diabetes was higher in the treated group when compared to the untreated patients. However, there were no significant differences in the indices of glucose homeostasis, low grade inflammation, oxidative stress and individual components of metabolic syndrome between the two groups. The triple negative patients were more prone to develop metabolic syndrome when compared to the triple positive patients.
   Conclusion: Suitable therapeutic approaches may be planned out to address the metabolic syndrome and its related complications among breast cancer patients especially during the course of treatment. (C) 2021 Diabetes India. Published by Elsevier Ltd. All rights reserved.
C1 [Gomes, Slanda Litty; Bobby, Zachariah; Saroja, Kovvuri; Parameswari, G. Renuka] JIPMER, Dept Biochem, Pondicherry 605006, India.
   [Ganesan, Prasanth] JIPMER, Dept Med Oncol, Pondicherry, India.
C3 Jawaharlal Institute of Postgraduate Medical Education & Research;
   Jawaharlal Institute of Postgraduate Medical Education & Research
RP Bobby, Z (corresponding author), JIPMER, Dept Biochem, Pondicherry 605006, India.
EM zacbobby@yahoo.com
RI Zachariah, Bobby/IUQ-0806-2023; Ganesan, Prasanth/H-1545-2013
OI Ganesan, Prasanth/0000-0003-2762-6591
FU JIPMER, Puducherry, India
FX The study was supported by Intramural grant from JIPMER, Puducherry,
   India to the first author.
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NR 26
TC 1
Z9 1
U1 0
U2 4
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1871-4021
EI 1878-0334
J9 DIABETES METAB SYND
JI Diabetes Metab. Syndr.-Clin. Res. Rev.
PD MAY-JUN
PY 2021
VL 15
IS 3
BP 975
EP 980
DI 10.1016/j.dsx.2021.04.022
EA MAY 2021
PG 6
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA SS6OB
UT WOS:000661873400048
PM 33962149
DA 2025-06-11
ER

PT J
AU Copur, S
   Demiray, A
   Kanbay, M
AF Copur, Sidar
   Demiray, Atalay
   Kanbay, Mehmet
TI Uric acid in metabolic syndrome: Does uric acid have a definitive role?
SO EUROPEAN JOURNAL OF INTERNAL MEDICINE
LA English
DT Review
DE Uric acid; Metabolic syndrome; Inflammation; Cardiovascular disease;
   Kidney disease
ID 3RD NATIONAL-HEALTH; NLRP3 INFLAMMASOME; INSULIN-RESISTANCE; OXIDATIVE
   STRESS; DOWN-REGULATION; GOUT RISK; HYPERURICEMIA; ACTIVATION;
   INHIBITION; PROTEIN
AB Increased serum uric acid (SUA) levels are commonly seen in patients with metabolic syndrome and are widely accepted as risk factors for hypertension, gout, non-alcoholic fatty liver disease, chronic kidney disease (CKD), and cardiovascular diseases. Although some ambiguity for the exact role of uric acid (UA) in these diseases is still present, several pathophysiological mechanisms have been identified such as increased oxidative stress, inflammation, and apoptosis. Accumulating evidence in genomics enlightens genetic variabilities and some epigenetic changes that can contribute to hyperuricemia. Here we discuss the role of UA within metabolism and the consequences of asymptomatic hyperuricemia while providing newfound evidence for the associations between UA and gut microbiota and vitamin D. Increased SUA levels and beneficial effects of lowering SUA levels need to be elucidated more to understand its complicated function within different metabolic pathways and set optimal target levels for SUA for reducing risks for metabolic and cardiovascular diseases.
C1 [Copur, Sidar; Demiray, Atalay] Koc Univ, Sch Med, Dept Med, Istanbul, Turkey.
   [Kanbay, Mehmet] Koc Univ, Sch Med, Dept Med, Div Nephrol, Istanbul, Turkey.
C3 Koc University; Koc University
RP Kanbay, M (corresponding author), Koc Univ, Sch Med, Dept Med, Div Nephrol, Istanbul, Turkey.
EM mkanbay@ku.edu.tr
RI 1, 1/IAO-4606-2023; Çöpür, Mazlum/AAT-7591-2021; Demiray,
   Atalay/AAR-1682-2021
OI Demiray, Atalay/0000-0001-5503-5305; Kanbay, Mehmet/0000-0002-1297-0675
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NR 105
TC 146
Z9 151
U1 39
U2 114
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0953-6205
EI 1879-0828
J9 EUR J INTERN MED
JI Eur. J. Intern. Med.
PD SEP
PY 2022
VL 103
BP 4
EP 12
DI 10.1016/j.ejim.2022.04.022
PG 9
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 6M4CE
UT WOS:000888816500002
PM 35508444
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Saben, JL
   Asghar, Z
   Rhee, JS
   Drury, A
   Scheaffer, S
   Moley, KH
AF Saben, Jessica L.
   Asghar, Zeenat
   Rhee, Julie S.
   Drury, Andrea
   Scheaffer, Suzanne
   Moley, Kelle H.
TI Excess Maternal Fructose Consumption Increases Fetal Loss and Impairs
   Endometrial Decidualization in Mice
SO ENDOCRINOLOGY
LA English
DT Article
ID URIC-ACID; UTERINE EXPRESSION; METABOLIC SYNDROME; SIGNALING PATHWAY;
   OXIDATIVE STRESS; PROGESTERONE; IMPLANTATION; PREGNANCY; LACTATION;
   FOXO1A
AB The most significant increase in metabolic syndrome over the previous decade occurred in women of reproductive age, which is alarming given that metabolic syndrome is associated with reproductive problems including subfertility and early pregnancy loss. Individuals with metabolic syndrome often consume excess fructose, and several studies have concluded that excess fructose intake contributes to metabolic syndrome development. Here, we examined the effects of increased fructose consumption on pregnancy outcomes in mice. Female mice fed a high-fructose diet (HFrD) for 6 weeks developed glucose intolerance and mild fatty liver but did not develop other prominent features of metabolic syndrome such as weight gain, hyperglycemia, and hyperinsulinemia. Upon mating, HFrD-exposed mice had lower pregnancy rates and smaller litters at midgestation than chow-fed controls. To explain this phenomenon, we performed artificial decidualization experiments and found that HFrD consumption impaired decidualization. This appeared to be due to decreased circulating progesterone as exogenous progesterone administration rescued decidualization. Furthermore, HFrD intake was associated with decreased bone morphogenetic protein 2 expression and signaling, both of which were restored by exogenous progesterone. Finally, expression of forkhead box O1 and superoxide dismutase 2 [Mn] proteins were decreased in the uteri of HFrD-fed mice, suggesting that HFrD consumption promotes a prooxidative environment in the endometrium. In summary, these data suggest that excess fructose consumption impairs murine fertility by decreasing steroid hormone synthesis and promoting an adverse uterine environment.
C1 [Saben, Jessica L.; Asghar, Zeenat; Rhee, Julie S.; Drury, Andrea; Scheaffer, Suzanne; Moley, Kelle H.] Washington Univ, Sch Med, Dept Obstet & Gynecol, St Louis, MO 63110 USA.
C3 Washington University (WUSTL)
RP Moley, KH (corresponding author), Washington Univ, BJC Inst Hlth, 425 South Euclid Ave,Box 8064, St Louis, MO 63110 USA.
EM moleyk@wustl.edu
RI Saben, Jessica/IUO-1267-2023
OI saben, jessica/0000-0002-9873-025X; Shyr, Zeenat/0000-0001-8710-9938
FU National Institutes of Health [R01HD065435, T32HD049305, T32HD040135]
FX This work was supported by National Institutes of Health Grants
   R01HD065435 (to K.H.M.), T32HD049305 (to J.L.S.), and T32HD040135 (to
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NR 54
TC 25
Z9 25
U1 0
U2 11
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0013-7227
EI 1945-7170
J9 ENDOCRINOLOGY
JI Endocrinology
PD FEB
PY 2016
VL 157
IS 2
BP 956
EP 968
DI 10.1210/en.2015-1618
PG 13
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA DD5LT
UT WOS:000369965900045
PM 26677880
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Sánchez, E
   Baena-Fustegueras, JA
   de la Fuente, MC
   Gutiérrez, L
   Bueno, M
   Ros, S
   Lecube, A
AF Sanchez, Enric
   Antonio Baena-Fustegueras, Juan
   Cruz de la Fuente, Maria
   Gutierrez, Liliana
   Bueno, Marta
   Ros, Susana
   Lecube, Albert
TI Advanced glycation end-products in morbid obesity and after bariatric
   surgery: When glycemic memory starts to fail
SO ENDOCRINOLOGIA DIABETES Y NUTRICION
LA English
DT Article
DE Advanced glycation end-products; Morbid obesity; Metabolic syndrome;
   Bariatric surgery
ID SKIN AUTOFLUORESCENCE; HEMODIALYSIS-PATIENTS; MORTALITY; STRESS;
   ACCUMULATION; PHENOTYPE
AB Background and objective: Advanced glycation end-products (AGEs) are a marker of metabolic memory. Their levels increases when oxidative stress, inflammation, or chronic hyperglycemia exists. The role of morbid obesity in AGE levels, and the impact of bariatric surgery on them are unknown.
   Patients and method: An observational study with three sex-and age-matched cohorts: 52 patients with obesity, 46 patients undergoing bariatric surgery in the last 5 years, and 46 control subjects. AGE were measured using skin autofluorescence (SAF) in the forearm with an AGE Reader (TM) (DiagnOptics Technologies, Groningen, The Netherlands). Presence of metabolic syndrome was assessed.
   Results: Patients with morbid obesity had higher SAF levels (2.14 +/- 0.65 AU) than non-obese subjects (1.81 +/- 0.22 AU; P < .001), which was mainly attributed to obese subjects with metabolic syndrome (2.44 +/- 0.67 vs. 1.86 +/- 0.51 AU; P < .001). After bariatric surgery, SAF continued to be high (2.18 +/- 0.40 AU), and greater as compared to the non-obese population (P < .001). A multivariate analysis showed that age and presence of metabolic syndrome ( but not sex or body mass index) were independently associated to SAF (R-2 = 0.320).
   Conclusion: SAF is increased in patients with morbid obesity and metabolic syndrome, mainly because of the existence of type 2 diabetes mellitus. In the first 5 years following bariatric surgery, weight loss and metabolic improvement are not associated with a parallel decrease in subcutaneous AGE levels. (C) 2016 SEEN. Published by Elsevier Espana, S.L.U. All rights reserved.
C1 [Sanchez, Enric; Gutierrez, Liliana; Bueno, Marta; Lecube, Albert] Univ Lleida, IRB Lleida, Hosp Univ Arnau de Vilanova, Serv Endocrinol & Nutr, Lleida, Spain.
   [Antonio Baena-Fustegueras, Juan; Cruz de la Fuente, Maria] Univ Lleida, IRB Lleida, Hosp Univ Arnau de Vilanova, Dept Cirugia Gen, Lleida, Spain.
   [Lecube, Albert] ISCIII, CIBER Diabet & Enfermedades Metabol Asociadas CIB, Madrid, Spain.
C3 Universitat de Lleida; University Hospital Arnau de Vilanova; Institut
   de Recerca Biomedica - IRB Lleida; University Hospital Arnau de
   Vilanova; Universitat de Lleida; Institut de Recerca Biomedica - IRB
   Lleida; CIBER - Centro de Investigacion Biomedica en Red; CIBERDEM;
   Instituto de Salud Carlos III
RP Lecube, A (corresponding author), Univ Lleida, IRB Lleida, Hosp Univ Arnau de Vilanova, Serv Endocrinol & Nutr, Lleida, Spain.; Lecube, A (corresponding author), ISCIII, CIBER Diabet & Enfermedades Metabol Asociadas CIB, Madrid, Spain.
EM alecube@gmail.com
RI Lecube, Albert/H-3813-2019; Silva, Carolina/KIH-3175-2024; Ros,
   Susana/AAV-3163-2021; Fustegueras, Juan/E-2912-2012; Bueno Díez,
   Marta/MSW-7716-2025; Sanchez, Enric/K-8225-2017
OI Bueno, Marta/0000-0001-9488-4553; Lecube, Albert/0000-0001-9684-0183;
   Sanchez, Enric/0000-0001-7345-1601
FU Instituto de Salud Carlos III [II14//00008]
FX This was supported by Instituto de Salud Carlos III (action plan
   II14//00008). This managing body had no role in study design, data
   collection, analysis and interpretation, report preparation, or the
   decision to submit the article for publication.
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NR 24
TC 16
Z9 17
U1 0
U2 9
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 2530-0180
J9 ENDOCRINOL DIAB NUTR
JI Endocrinol. Diabetes Nutr.
PD JAN
PY 2017
VL 64
IS 1
BP 4
EP 10
DI 10.1016/j.endien.2017.02.002
PG 7
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA EY2HZ
UT WOS:000403790500002
PM 28440769
DA 2025-06-11
ER

PT J
AU Fernández-Ruiz, VE
   Armero-Barranco, D
   Xandri-Graupera, JM
   Paniagua-Urbano, JA
   Solé-Agustí, M
   Mulero, J
AF Fernandez-Ruiz, V. E.
   Armero-Barranco, D.
   Xandri-Graupera, J. M.
   Paniagua-Urbano, J. A.
   Sole-Agusti, M.
   Mulero, J.
TI Roux-en-Y Gastric Bypass: Effective Against Metabolic and Psychiatric
   Comorbidity?
SO BIOLOGICAL RESEARCH FOR NURSING
LA English
DT Article
DE gastric bypass; metabolic syndrome; metabolic comorbidity; psychiatric
   comorbidity; cardiovascular risk
ID BARIATRIC SURGERY; CARDIOVASCULAR RISK; OBESITY; DEPRESSION; ANXIETY;
   PREVALENCE; THERAPY
AB Background: Roux-en-Y gastric bypass (RYGB) is considered the gold standard for gastric bypass, displaying better results for metabolic disorders than other surgical procedures over the long term. The aim of this study was to determine the effects of bariatric surgery, in particular the RYGB technique, on metabolic syndrome (MS) and other biochemical parameters implicit in the comorbid conditions associated with obesity, as well as to explore the influence of this surgical procedure on psychiatric comorbidity in the study population.
   Method: An observational retrospective cohort study based on 146 clinical records of patients having undergone RYGB between January 1, 2011, and January 1, 2014, was performed. Data related to metabolic and psychiatric comorbidity were gathered at three stages: prior to surgery and at 3 and 9 months following surgery.
   Results: There was a progressive and statistically significant reduction of all biochemical parameters analyzed at 3 and 9 months following surgery except high-density lipoprotein cholesterol, which significantly increased (beneficial) in value. These changes imply a remission of >90% for all metabolic disorders and the consequent tendency toward a reduction in prescribed pharmacological treatments, with MS found in only one subject at 9 months. There was, however, no significant reduction in pharmacological treatments for psychiatric comorbidities.
   Conclusion: Findings suggest that RYGB is an effective treatment for MS and other metabolic disorders but not for psychiatric comorbidities accompanying MS.
C1 [Fernandez-Ruiz, V. E.; Paniagua-Urbano, J. A.; Sole-Agusti, M.] Murcia Healthcare Serv, Murcia 30100, Spain.
   [Armero-Barranco, D.; Xandri-Graupera, J. M.] Univ Murcia, Fac Nursing, Murcia, Spain.
   [Mulero, J.] Catholic Univ San Antonio, Dept Food Technol & Nutr, Murcia, Spain.
C3 University of Murcia; Universidad Catolica de Murcia
RP Fernández-Ruiz, VE (corresponding author), Murcia Healthcare Serv, Murcia 30100, Spain.
EM virginiaesperanza.fernandez@um.es
OI Fernandez-Ruiz, VE/0000-0002-3976-3967
FU Public Healthcare Service of Murcia, Spain
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: This
   project was sponsored by the Public Healthcare Service of Murcia, Spain.
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NR 37
TC 4
Z9 4
U1 0
U2 3
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1099-8004
EI 1552-4175
J9 BIOL RES NURS
JI Biol. Res. Nurs.
PD MAR
PY 2017
VL 19
IS 2
SI SI
BP 162
EP 169
DI 10.1177/1099800416675406
PG 8
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA EL7BF
UT WOS:000394775400006
PM 28198200
DA 2025-06-11
ER

PT J
AU Zulet, MA
   Marti, A
   Parra, MD
   Martínez, JA
AF Zulet, MA
   Marti, A
   Parra, MD
   Martínez, JA
TI Inflammation and conjugated linoleic acid:: mechanisms of action and
   implications for human health
SO JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
LA English
DT Review
DE inflammation; oxidative stress; obesity; metabolic syndrome; conjugated
   linoleic acid
ID C-REACTIVE PROTEIN; ACTIVATED-RECEPTOR-GAMMA; CORONARY-HEART-DISEASE;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; OXIDATIVE STRESS; WEIGHT-LOSS;
   POTENTIAL MECHANISMS; CLOSE ASSOCIATION; GLUCOSE-TOLERANCE
AB Data from a number of studies and trials have shown that different conjugated linoleic acids (CLA's) may produce beneficial effects on cancer, atherosclerosis, hypertension, diabetes and changes in body composition. Despite the increasing knowledge about CLA's implications on health, the mechanism of action of these fatty acids is not completely understood. Moreover, human studies indicate that some of these beneficial effects are considerably less evident than anticipated from mice studies, while the efficacy and safety of dietary supplements containing CLA have been questioned in some intervention trials. Recently, it has been suggested that the anti-carcinogenic and anti-atherosclerosis effects of CLA's stem from its anti-inflammatory properties. Because inflammatory responses are associated with the pathophysiology of many diseases, including obesity and the metabolic syndrome, the investigation in this area is of growing interest in recent years.
C1 Univ Navarra, Fac Farm, Dept Fisiol & Nutr, Pamplona 31008, Spain.
C3 University of Navarra
RP Univ Navarra, Fac Farm, Dept Fisiol & Nutr, C Irunlarrea 1, Pamplona 31008, Spain.
EM jalfmtz@unav.es
RI ; Zulet, M. Angeles/H-1317-2017; Martinez Hernandez, J
   Alfredo/K-8709-2014; Marti del Moral, Amelia/H-1192-2017
OI Parra-Astorgano, Lola/0009-0008-1231-2884; Zulet, M.
   Angeles/0000-0002-3926-0892; Martinez Hernandez, J
   Alfredo/0000-0001-5218-6941; Marti del Moral, Amelia/0000-0001-9832-7981
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NR 82
TC 46
Z9 51
U1 1
U2 8
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1138-7548
EI 1877-8755
J9 J PHYSIOL BIOCHEM
JI J. Physiol. Biochem.
PD SEP
PY 2005
VL 61
IS 3
BP 483
EP 494
DI 10.1007/BF03168454
PG 12
WC Biochemistry & Molecular Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Physiology
GA 004KH
UT WOS:000234751200007
PM 16440602
DA 2025-06-11
ER

PT S
AU Alidadi, M
   Sahebkar, A
   Eslami, S
   Vakilian, F
   Jarahi, L
   Alinezhad-Namaghi, M
   Arabi, SM
   Vakili, S
   Tohidinezhad, F
   Nikooiyan, Y
   Norouzy, A
AF Alidadi, Mona
   Sahebkar, Amirhossein
   Eslami, Saeid
   Vakilian, Farveh
   Jarahi, Lida
   Alinezhad-Namaghi, Maryam
   Arabi, Seyed Mostafa
   Vakili, Saba
   Tohidinezhad, Fariba
   Nikooiyan, Yasaman
   Norouzy, Abdolreza
BE Barreto, GE
   Sahebkar, A
TI The Effect of Curcumin Supplementation on Pulse Wave Velocity in
   Patients with Metabolic Syndrome: A Randomized, Double-Blind,
   Placebo-Controlled Trial
SO PHARMACOLOGICAL PROPERTIES OF PLANT-DERIVED NATURAL PRODUCTS AND
   IMPLICATIONS FOR HUMAN HEALTH
SE Advances in Experimental Medicine and Biology
LA English
DT Article; Book Chapter
DE Arterial stiffness; Vascular stiffness; Vascular aging; Arterial aging;
   Pulse wave velocity; Augmentation index; Curcuminoid; Curcumin;
   Turmeric; Metabolic syndrome; Obesity
ID AORTIC AUGMENTATION INDEX; FATTY LIVER-DISEASE; ARTERIAL STIFFNESS;
   CARDIOVASCULAR EVENTS; OXIDATIVE STRESS; INFLAMMATORY RESPONSE;
   INSULIN-RESISTANCE; TNF-ALPHA; GLUCOSE; RISK
AB Cardiovascular disease is a leading cause of death in many societies. Arterial stiffness is an initial sign of structural and functional changes in the arterial wall. Pulse wave velocity (PWV) is the gold standard for non-invasive evaluation of aortic stiffness and a modifiable cardiovascular risk factor. Curcumin is a major component of turmeric with known anti-inflammatory and anti-oxidative effects. Since arterial stiffness is affected by inflammation and oxidative stress, it may be improved by curcumin supplementation. The purpose of this clinical trial was to investigate the potential effects of curcumin on improving arterial stiffness in patients with metabolic syndrome. This placebo-controlled, double-blind, randomized clinical trial was conducted among metabolic syndrome patients. Sixty-six eligible individuals were randomly assigned to active intervention or control groups. The active intervention group received curcumin supplement at a dose of 500 mg daily for 12 weeks, whereas the control group received placebo capsule. Physical activity, daily dietary energy intake, anthropometric body composition, and biochemical hemodynamic and arterial stiffness parameters were evaluated at baseline and at the end of the study. Body weight decreased significantly in the curcumin group compared to placebo. Also, curcumin intervention improved PWV, which remained significant after adjustment for potential confounding factors (p = 0.011). The current clinical trial demonstrated that daily intake of 500 mg of curcumin for 12 weeks can lead to the improvement of arterial stiffness and weight management among subjects with metabolic syndrome.
C1 [Alidadi, Mona; Alinezhad-Namaghi, Maryam; Arabi, Seyed Mostafa; Norouzy, Abdolreza] Mashhad Univ Med Sci, Fac Med, Dept Nutr, Mashhad, Razavi Khorasan, Iran.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Appl Biomed Res Ctr, Mashhad, Razavi Khorasan, Iran.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Biotechnol Res Ctr, Mashhad, Razavi Khorasan, Iran.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Sch Pharm, Mashhad, Razavi Khorasan, Iran.
   [Sahebkar, Amirhossein] Polish Mothers Mem Hosp Res Inst PMMHRI, Lodz, Poland.
   [Eslami, Saeid; Tohidinezhad, Fariba] Mashhad Univ Med Sci, Fac Med, Dept Med Informat, Mashhad, Razavi Khorasan, Iran.
   [Vakilian, Farveh] Mashhad Univ Med Sci, Fac Med, Dept Cardiol, Mashhad, Razavi Khorasan, Iran.
   [Jarahi, Lida] Mashhad Univ Med Sci, Dept Community Med, Mashhad, Razavi Khorasan, Iran.
   [Vakili, Saba] Mashhad Univ Med Sci, Med Genet Res Ctr, Mashhad, Razavi Khorasan, Iran.
   [Nikooiyan, Yasaman] Mashhad Univ Med Sci, Fac Med, Mashhad, Razavi Khorasan, Iran.
C3 Mashhad University of Medical Sciences; Mashhad University of Medical
   Sciences; Mashhad University of Medical Sciences; Mashhad University of
   Medical Sciences; Mashhad University of Medical Sciences; Mashhad
   University of Medical Sciences; Mashhad University of Medical Sciences;
   Mashhad University of Medical Sciences; Mashhad University of Medical
   Sciences
RP Norouzy, A (corresponding author), Mashhad Univ Med Sci, Fac Med, Dept Nutr, Mashhad, Razavi Khorasan, Iran.
EM norouzya@mums.ac.ir
RI Eslami, Saeid/AAZ-6005-2020; Norouzy, Abdolreza/AAX-1160-2020;
   Alinezhad-Namaghi, Maryam/HKM-8759-2023; Arabi, Seyyed
   Mostafa/ABF-1610-2021; Jarahi, Lida/AAY-5973-2020; Sahebkar,
   Amirhossein/B-5124-2018
OI Alinezhad-Namaghi, Maryam/0000-0001-9425-7496
FU Research Council of the Mashhad University of Medical Sciences, Mashhad,
   Iran
FX This research was financed by Research Council of the Mashhad University
   of Medical Sciences, Mashhad, Iran. The results reported in this paper
   have been derived from a postgraduate thesis (Thesis No: 1445) in
   Mashhad University of Medical Sciences, Mashhad, Iran.
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NR 56
TC 26
Z9 27
U1 0
U2 12
PU SPRINGER INTERNATIONAL PUBLISHING AG
PI CHAM
PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND
SN 0065-2598
EI 2214-8019
BN 978-3-030-64872-5; 978-3-030-64871-8
J9 ADV EXP MED BIOL
JI Adv.Exp.Med.Biol.
PY 2021
VL 1308
BP 1
EP 11
DI 10.1007/978-3-030-64872-5_1
D2 10.1007/978-3-030-64872-5
PG 11
WC Chemistry, Medicinal; Medicine, Research & Experimental; Pharmacology &
   Pharmacy
WE Book Citation Index – Science (BKCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Research & Experimental Medicine
GA BR3MG
UT WOS:000647701200001
PM 33861432
DA 2025-06-11
ER

PT J
AU Jamshidi, S
   Hejazi, N
   Golmakani, MT
   Tanideh, N
AF Jamshidi, Sanaz
   Hejazi, Najmeh
   Golmakani, Mohammad-Taghi
   Tanideh, Nader
TI Wild pistachio (Pistacia atlantica mutica) oil improve metabolic
   syndrome features in rats with high fructose ingestion
SO IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
LA English
DT Article
DE Insulin resistance; Inflammation; Lipidemia; Metabolic syndrome; Oil;
   Pistacia
ID MONOUNSATURATED FATTY-ACIDS; OLIVE OIL; INSULIN-RESISTANCE; OXIDATIVE
   STRESS; OLEIC-ACID; GLUCOSE; ANTIOXIDANT; DESF.; CHOLESTEROL;
   ASSOCIATION
AB Objective(s): Metabolic syndrome is a multiplex risk factor for diabetes and cardiovascular disease. Since some dietary fats such as mono-unsaturated fatty acids (MUFA) modify metabolic syndrome components the aim of the present study was to evaluate the preventive effects of mixture, kernel and hull oils of wild pistachio (WP) (Pistacia atlantica mutica) as good sources of MUFA on different features of this abnormality in rats under induction.
   Materials and Methods: In this study rats were randomly assigned to six groups with 12 animals per group. Metabolic syndrome was induced by fructose solution in groups 2, 3,4, 5, and 6. Group 3 received sunflower oil and groups 4, 5, and 6 received mixture, hull and kernel oils of WP (2 ml/kg/day), respectively, for 10 weeks. Then, lipid profiles, glycemic indices, oxidative stress and inflammatory parameters were measured using standard laboratory tests.
   Results: Different forms of WP oil induced hypotriglyceridemia, but the hypocholesterolemia effect was seen only in the mixed and kernel oil groups. Kernel oil also significantly reduced LDL and HDL cholesterol (P<0.05). In addition, mixed and kernel oils notably decreased glycemic indices (fasting blood glucose and insulin resistance) compared with the fructose group. Serum insulin levels were significantly increased in the kernel oil group (P<0.05). All WP oils also significantly decreased inflammation (IL-6).
   Conclusion: The results showed that the consumption of WP kernel oil may have beneficial effects on preventing hyperglycemia, hypertriglyceridemia, hypercholesterolemia, inflammation and pancreatic secretory disorders.
C1 [Jamshidi, Sanaz] Shiraz Univ Med Sci, Sch Nutr & Food Sci, Dept Clin Nutr, Shiraz, Iran.
   [Hejazi, Najmeh] Shiraz Univ Med Sci, Nutr Res Ctr, Sch Nutr & Food Sci, Dept Clin Nutr, Shiraz, Iran.
   [Golmakani, Mohammad-Taghi] Shiraz Univ, Sch Agr, Dept Food Sci & Technol, Shiraz, Iran.
   [Tanideh, Nader] Shiraz Univ Med Sci, Stem Cell & Transgen Res Ctr, Shiraz, Iran.
C3 Shiraz University of Medical Science; Shiraz University of Medical
   Science; Shiraz University; Shiraz University of Medical Science
RP Hejazi, N (corresponding author), Shiraz Univ Med Sci, Nutr Res Ctr, Sch Nutr & Food Sci, Dept Clin Nutr, Shiraz, Iran.
EM najmehhejazi@gmail.com
RI Tanideh, Nader/M-3336-2013; Hejazi, Najmeh/R-4345-2017; Golmakani,
   Mohammad-Taghi/D-1387-2017
OI Hejazi, Najmeh/0000-0003-2664-6208; Golmakani,
   Mohammad-Taghi/0000-0001-5173-1178
FU Shiraz University of Medical Sciences, Shiraz, I.R. Iran
   [95-01-84-12937]
FX The results described in this paper were part of student thesis written
   by Sanaz Jamshidi and was financially supported (Grant no
   #95-01-84-12937) by the Vice Chancellery of Research and Technology in
   Shiraz University of Medical Sciences, Shiraz, I.R. Iran. The authors
   would like to thank the Center for Development of Clinical Research of
   Nemazee Hospital and Dr. Nasrin Shokrpour for editorial assistance.
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NR 55
TC 9
Z9 9
U1 0
U2 5
PU MASHHAD UNIV MED SCIENCES
PI MASHHAD
PA VICE-CHANCELLOR FOR RES CTR OFF IJBMS, DANESHGAH ST, PO BOX 9138813944 -
   445, MASHHAD, 00000, IRAN
SN 2008-3866
EI 2008-3874
J9 IRAN J BASIC MED SCI
JI Iran. J. Basic Med. Sci.
PD DEC
PY 2018
VL 21
IS 12
BP 1255
EP 1261
DI 10.22038/ijbms.2018.30511.7351
PG 7
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA GX7EB
UT WOS:000447926600009
PM 30627369
DA 2025-06-11
ER

PT J
AU Candi, E
   Tesauro, M
   Cardillo, C
   Lena, AM
   Schinzari, F
   Rodia, G
   Sica, G
   Gentileschi, P
   Rovella, V
   Annicchiarico-Petruzzelli, M
   Di Daniele, N
   Melino, G
AF Candi, Eleonora
   Tesauro, Manfredi
   Cardillo, Carmine
   Lena, Anna Maria
   Schinzari, Francesca
   Rodia, Giuseppe
   Sica, Giuseppe
   Gentileschi, Paolo
   Rovella, Valentina
   Annicchiarico-Petruzzelli, Margherita
   Di Daniele, Nicola
   Melino, Gerry
TI Metabolic profiling of visceral adipose tissue from obese subjects with
   or without metabolic syndrome
SO BIOCHEMICAL JOURNAL
LA English
DT Article
ID TYPE-2 DIABETES-MELLITUS; INSULIN-RESISTANCE; OXIDATIVE STRESS;
   CARDIOVASCULAR-DISEASES; VASCULAR DYSFUNCTION; FATTY LIVER;
   SPHINGOMYELIN; ATHEROSCLEROSIS; ADIPOGENESIS; INFLAMMATION
AB Obesity represents one of the most complex public health challenges and has recently reached epidemic proportions. Obesity is also considered to be primarily responsible for the rising prevalence of metabolic syndrome, defined as the coexistence in the same individual of several risk factors for atherosclerosis, including dyslipidemia, hypertension and hyperglycemia, as well as for cancer. Additionally, the presence of three of the five risk factors (abdominal obesity, low high-density lipoprotein cholesterol, high triglycerides, high fasting glucose and high blood pressure) characterizes metabolic syndrome, which has serious clinical consequences. The current study was conducted in order to identify metabolic differences in visceral adipose tissue (VAT) collected from obese (body mass index 43-48) human subjects who were diagnosed with metabolic syndrome, obese individuals who were metabolically healthy and nonobese healthy controls. Extensive gas chromatography/mass spectrometry (GC/MS) and liquid chromatography/mass spectrometry (LC/MS/MS) analyses were used to obtain the untargeted VAT metabolomic profiles of 481 metabolites belonging to all biochemical pathways. Our results indicated consistent increases in oxidative stress markers from the pathologically obese samples in addition to subtle markers of elevated glucose levels that may be consistent with metabolic syndrome. In the tissue derived from the pathologically obese subjects, there were significantly elevated levels of plasmalogens, which may be increased in response to oxidative changes in addition to changes in glycerolphosphorylcholine, glycerolphosphorylethanolamine glycerolphosphorylserine, ceramides and sphingolipids. These data could be potentially helpful for recognizing new pathways that underlie the metabolic-vascular complications of obesity and may lead to the development of innovative targeted therapies.
C1 [Candi, Eleonora; Lena, Anna Maria; Sica, Giuseppe; Gentileschi, Paolo; Melino, Gerry] Univ Roma Tor Vergata, Dept Expt Med & Surg, I-00133 Rome, Italy.
   [Candi, Eleonora; Annicchiarico-Petruzzelli, Margherita] Ist Dermopat Immacolata IDI IRCCS, Biochem Lab, I-00100 Rome, Italy.
   [Tesauro, Manfredi; Rodia, Giuseppe; Rovella, Valentina; Di Daniele, Nicola] Univ Roma Tor Vergata, Dept Syst Med, I-00133 Rome, Italy.
   [Cardillo, Carmine; Schinzari, Francesca] Catholic Univ, Dept Internal Med, I-00168 Rome, Italy.
   [Melino, Gerry] Univ Leicester, Toxicol Unit, MRC, Hodgkin Bldg,Lancaster Rd,POB 138, Leicester LE1 9HN, Leics, England.
C3 University of Rome Tor Vergata; IRCCS Istituto Dermopatico
   dell'Immacolata (IDI); University of Rome Tor Vergata; Catholic
   University of the Sacred Heart; IRCCS Policlinico Gemelli; University of
   Leicester
RP Melino, G (corresponding author), Univ Roma Tor Vergata, Dept Expt Med & Surg, I-00133 Rome, Italy.; Di Daniele, N (corresponding author), Univ Roma Tor Vergata, Dept Syst Med, I-00133 Rome, Italy.; Melino, G (corresponding author), Univ Leicester, Toxicol Unit, MRC, Hodgkin Bldg,Lancaster Rd,POB 138, Leicester LE1 9HN, Leics, England.
EM didaniele@med.uniroma2.it
RI schinzari, francesca/AAB-9982-2019; Rovella, Valentina/AAB-9727-2019;
   Lena, Anna/AAI-5042-2020; Annicchiarico-Petruzzelli,
   Margherita/AAG-7746-2020
OI Tesauro, Manfredi/0000-0002-3967-1552; Cardillo,
   Carmine/0000-0001-5182-3005; Gentileschi, Paolo/0009-0007-3068-9848;
   Candi, Eleonora/0000-0001-8332-4825; Lena, Anna
   Maria/0000-0001-6285-9927; Annicchiarico-Petruzzelli,
   Margherita/0000-0002-4717-4740; Rovella, Valentina/0000-0002-3311-486X
FU 'Fondazione Roma' NCD; Ministero Sanita (IDI-IRCCS R.C.); MAECI
   [CN18GR09]; MRC [MC_U132670600] Funding Source: UKRI
FX This work was mainly supported by 'Fondazione Roma' NCD (to G.M., E.C.,
   N.D.D. and M.T.), partially supported by Ministero Sanita (IDI-IRCCS
   R.C. to G.M. and E.C.) and MAECI (CN18GR09 to G.M.).
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NR 61
TC 57
Z9 61
U1 0
U2 30
PU PORTLAND PRESS LTD
PI LONDON
PA CHARLES DARWIN HOUSE, 12 ROGER STREET, LONDON WC1N 2JU, ENGLAND
SN 0264-6021
EI 1470-8728
J9 BIOCHEM J
JI Biochem. J.
PD MAR 15
PY 2018
VL 475
BP 1019
EP 1035
DI 10.1042/BCJ20170604
PN 5
PG 17
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA GA1OV
UT WOS:000428087500013
PM 29437994
DA 2025-06-11
ER

PT J
AU Uzu, T
   Nishimura, M
   Fujii, T
   Sakaguchi, M
   Kanasaki, M
   Isshiki, K
   Araki, S
   Sugiomoto, T
   Kashiwagi, A
   Kimura, G
AF Uzu, Takashi
   Nishimura, Masataka
   Fujii, Takashi
   Sakaguchi, Masayoshi
   Kanasaki, Masami
   Isshiki, Keiji
   Araki, Shin-ichi
   Sugiomoto, Toshiro
   Kashiwagi, Atsunori
   Kimura, Genjiro
TI Benidipine attenuates glomerular hypertension and reduces albuminuria in
   patients with metabolic syndrome
SO HYPERTENSION RESEARCH
LA English
DT Article
DE benidipine; renal hemodynamics; albuminuria; metabolic syndrome
ID HIGH SODIUM SENSITIVITY; BLOOD-PRESSURE; CIRCADIAN-RHYTHM; OXIDATIVE
   STRESS; HEMODYNAMICS; NATRIURESIS; NONDIPPER; AFFERENT
AB Recent studies have shown that metabolic syndrome is associated with an increased risk for chronic kidney disease. We recently found that the prevalence of sodium-sensitive hypertension in patients with metabolic syndrome was significantly higher than that in patients with essential hypertension but without metabolic syndrome. We therefore assessed the effects of benidipine, a long-acting calcium channel blocker, on the sodium sensitivity of blood pressure and renal hemodymarnics in 5 patients with metabolic syndrome. Glomerular hemodynamics were assessed using pressure-natriuresis curves, which were constructed by plotting the urinary excretion of sodium as a function of the mean arterial pressure, which was calculated as the mean of 48 values based on 24-h monitoring, during the intake of low (3 g NaCl daily) and relatively high (10 g NaCl daily) sodium diets. Under the relatively high sodium diet condition, benidipine significantly lowered systolic and diastolic blood pressure. The pressure-natriuresis curve was steeper after the administration of benidipine. Benidipine lowered glomerular capillary hydraulic pressure (P-GC) levels (from 54.4 +/- 7.5 to 47.0 +/- 7.0 mmHg, p=0.0152) and reduced both the resistance of the afferent arterioles (from 10,338 +/- 2,618 to 9,026 +/- 2,627 dyn.s/cm(5), p=0.047) and the resistance of the efferent arterioles (from 4,649 +/- 2,039 to 2,419 +/- 2,081 dyn.s/cm(5), p=0.003). The urinary albumin excretion rate also decreased after the administration of benidipine. These findings indicated that benidipine may be effective for reducing the risk of developing chronic kidney disease in patients with metabolic syndrome.
C1 Shiga Univ Med Sci, Dept Med, Otsu, Shiga 5202192, Japan.
   Nagahama City Hosp, Nagahama, Japan.
   Higashi Osaka City Gen Hosp, Higashiosaka, Osaka, Japan.
   Nagoya City Univ, Dept Internal Med & Pathophysiol, Grad Sch Med Sci, Nagoya, Aichi, Japan.
C3 Shiga University of Medical Science; Nagoya City University
RP Uzu, T (corresponding author), Shiga Univ Med Sci, Dept Med, Seta Tsukinowa Cho, Otsu, Shiga 5202192, Japan.
EM takuzu@belle.shiga-med.ac.jp
RI Kashiwagi, Atsunori/H-8712-2019; Koya, Daisuke/J-3257-2014
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NR 25
TC 17
Z9 19
U1 0
U2 1
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0916-9636
EI 1348-4214
J9 HYPERTENS RES
JI Hypertens. Res.
PD FEB
PY 2007
VL 30
IS 2
BP 161
EP 165
DI 10.1291/hypres.30.161
PG 5
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 161PD
UT WOS:000246026700010
PM 17460386
OA Bronze
DA 2025-06-11
ER

PT J
AU Bashir, B
   Adam, S
   Ho, JH
   Linn, Z
   Durrington, PN
   Soran, H
AF Bashir, Bilal
   Adam, Safwaan
   Ho, Jan H.
   Linn, Zara
   Durrington, Paul N.
   Soran, Handrean
TI Established and potential cardiovascular risk factors in metabolic
   syndrome: Effect of bariatric surgery
SO CURRENT OPINION IN LIPIDOLOGY
LA English
DT Review
DE bariatric surgery; fatty liver; HDL function; metabolic syndrome;
   obstructive sleep apnoea
ID CORONARY-HEART-DISEASE; LOW-DENSITY-LIPOPROTEIN; INSULIN-RESISTANCE;
   OXIDIZED PHOSPHOLIPIDS; FOLLOW-UP; NONFASTING TRIGLYCERIDES; CAROTID
   ATHEROSCLEROSIS; MYOCARDIAL-INFARCTION; LYMPHOCYTE RATIO; FAT
   ACCUMULATION
AB Purpose of reviewThe aim of this review was to provide an overview of the role of novel biomarkers in metabolic syndrome, their association with cardiovascular risk and the impact of bariatric surgery on these biomarkers.Recent findingsMetabolic syndrome encompasses an intricate network of health problems, and its constituents extend beyond the components of its operational definition. Obesity-related dyslipidaemia not only leads to quantitative changes in lipoprotein concentration but also alteration in qualitative composition of various lipoprotein subfractions, including HDL particles, rendering them proatherogenic. This is compounded by the concurrent existence of obstructive sleep apnoea (OSA) and nonalcoholic fatty liver disease (NAFLD), which pave the common pathway to inflammation and oxidative stress culminating in heightened atherosclerotic cardiovascular disease (ASCVD) risk. Bariatric surgery is an exceptional modality to reverse both conventional and less recognised aspects of metabolic syndrome. It reduces the burden of atherosclerosis by ameliorating the impact of obesity and its related complications (OSA, NAFLD) on quantitative and qualitative composition of lipoproteins, ultimately improving endothelial function and cardiovascular morbidity and mortality.SummarySeveral novel biomarkers, which are not traditionally considered as components of metabolic syndrome play a crucial role in determining ASCVD risk in metabolic syndrome. Due to their independent association with ASCVD, it is imperative that these are addressed. Bariatric surgery is a widely recognized intervention to improve the conventional risk factors associated with metabolic syndrome; however, it also serves as an effective treatment to optimize novel biomarkers.
C1 [Bashir, Bilal; Linn, Zara; Durrington, Paul N.; Soran, Handrean] Univ Manchester, Fac Biol Med & Hlth, Manchester, England.
   [Bashir, Bilal; Soran, Handrean] Manchester Univ NHS Fdn Trust, Ctr Endocrinol Diabet & Metab, Peter Mt Bldg, Manchester, England.
   [Adam, Safwaan; Ho, Jan H.] Christie NHS Fdn Trust, Manchester, England.
   [Soran, Handrean] Manchester Univ NHS Fdn Trust, Ctr Diabet Endocrinol & Metab, Manchester M13 0HY, England.
C3 University of Manchester; Manchester University NHS Foundation Trust;
   Christie NHS Foundation Trust; Manchester University NHS Foundation
   Trust
RP Soran, H (corresponding author), Manchester Univ NHS Fdn Trust, Ctr Diabet Endocrinol & Metab, Manchester M13 0HY, England.
EM handrean.soran@mft.nhs.uk
FU National Institute for Health Research; Manchester Biomedical Research
   Centre; Lipid Disease Fund
FX The authors acknowledge the support from National Institute for Health
   Research, Manchester Biomedical Research Centre and Lipid Disease Fund.
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NR 136
TC 3
Z9 3
U1 1
U2 12
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0957-9672
EI 1473-6535
J9 CURR OPIN LIPIDOL
JI Curr. Opin. Lipidology
PD OCT
PY 2023
VL 34
IS 5
BP 221
EP 233
DI 10.1097/MOL.0000000000000889
PG 13
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism; Peripheral
   Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism;
   Cardiovascular System & Cardiology
GA R2TU2
UT WOS:001062934000006
PM 37560987
DA 2025-06-11
ER

PT J
AU Khan, MI
   Anjum, FM
   Sohaib, M
   Sameen, A
AF Khan, Muhammad Issa
   Anjum, Faqir Muhammad
   Sohaib, Muhammad
   Sameen, Aysha
TI Tackling metabolic syndrome by functional foods
SO REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
LA English
DT Review
DE Functional foods; Metabolic syndrome; Hypertension; Dyslipidemia; Lipid
   profile
ID RANDOMIZED CONTROLLED-TRIALS; CORONARY-HEART-DISEASE; C-REACTIVE
   PROTEIN; OAT BETA-GLUCAN; CARDIOVASCULAR-DISEASE; RED-PEPPER;
   SERUM-CHOLESTEROL; ENERGY-METABOLISM; PSIDIUM-GUAJAVA; BLOOD-PRESSURE
AB The metabolic syndrome is one of the most vibrant and widely prevailing health concerns worldwide. It is characterized by several metabolic abnormalities, which involve obesity, insulin resistance, dyslipidemia, enhanced oxidative stress; hypertension and increased pro-inflammatory state that ultimate contribute towards poor health. The prevalence of metabolic syndrome in Pakistan according to different definitions is reported to be from 18 % to 46 %. Fifty percent of Pakistani population is at high risk of metabolic syndrome as being hypertensive. In studying dyslipidemia in Pakistan, hypertriglyceridemia is found in 27-54 % of the population, whereas 68-81 % has low levels of high-density lipoprotein (HDL). Population likes to eat healthier diet without changing their fundamental dietary pattern. Nutrition science has moved on from the classical concepts of avoiding nutrient deficiencies and basic nutritional adequacy to the concept of positive or optimal nutrition. Many traditional food products including fruits, vegetables, flaxseed, oat, barley, whole grains, soy and milk have been found to contain component with potential health benefits. Nowadays, functional foods are used in the prevention and amelioration of several chronic diseases, such as the metabolic syndrome. The relation of the consumption of certain functional foods and the improvement in health status is regulated through health claims. This review focuses on the different features of the metabolic syndrome and the influence of functional foods on these aspects, involving dyslipidemia, improvement of insulin sensitivity, serum lipid profile, antioxidant status, anti-inflammatory status and weight management of humans.
C1 [Khan, Muhammad Issa; Anjum, Faqir Muhammad; Sohaib, Muhammad; Sameen, Aysha] Univ Agr Faisalabad, Natl Inst Food Sci & Technol, Faisalabad, Pakistan.
C3 University of Agriculture Faisalabad
RP Khan, MI (corresponding author), Univ Agr Faisalabad, Natl Inst Food Sci & Technol, Faisalabad, Pakistan.
EM drkhan@uaf.edu.pk; dgnifsat@ymail.com; ftsohaib@homail.com;
   ayshasameen@uaf.edu.pk
RI SAMEEN, AYSHA/AAG-8064-2019; Sohaib, Muhammad/M-4978-2016; ANJUM,
   FAQIR/AAW-9311-2020; Khan, Muhammad Issa/J-3747-2015
OI Sameen, Aysha/0000-0002-3125-675X; Khan, Muhammad
   Issa/0000-0002-3241-1248; Sohaib, Muhammad/0000-0003-2743-3706
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NR 124
TC 20
Z9 23
U1 2
U2 57
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1389-9155
EI 1573-2606
J9 REV ENDOCR METAB DIS
JI Rev. Endocr. Metab. Disord.
PD SEP
PY 2013
VL 14
IS 3
BP 287
EP 297
DI 10.1007/s11154-013-9270-8
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 224JP
UT WOS:000324881200008
PM 24057596
DA 2025-06-11
ER

PT J
AU Salzer, L
   Tenenbaum-Gavish, K
   Hod, M
AF Salzer, Liat
   Tenenbaum-Gavish, Kinneret
   Hod, Moshe
TI Metabolic disorder of pregnancy (understanding pathophysiology of
   diabetes and preeclampsia)
SO BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
LA English
DT Article
DE gestational diabetes; gestational hypertension; obesity; insulin
   resistance; pathogenesis
ID GLUCOSE-TOLERANCE TEST; ACID-BINDING PROTEIN; INSULIN-RESISTANCE;
   GESTATIONAL HYPERTENSION; PLACENTAL-LACTOGEN; OXIDATIVE STRESS;
   LIPID-METABOLISM; PLASMA LEPTIN; OBESE WOMEN; RISK
AB The role of insulin resistance in human disease is implicated in the pathogenesis of some of the chief western chronic diseases: ischemic heart disease, type 2 diabetes mellitus, and essential hypertension. The occurrence of these diseases, alongside obesity, is termed the metabolic syndrome. Pregnancy is normally attended by progressive insulin resistance that begins near mid-pregnancy and progresses through the third trimester to levels that approximate the insulin resistance seen in individuals with type 2 diabetes. Insulin resistance and hyperinsulinemia may be the basic common ground for the metabolic syndrome of pregnancy - elevated blood pressure and diabetes mellitus. Moreover, the metabolic syndrome is also associated with endothelial dysfunction, oxidative stress, and attenuated inflammatory responses. In this review, we discuss the development of insulin resistance during pregnancy, hormones and newly discovered factors associated with insulin resistance and secretion, lipid metabolism, and the pathogenesis of hypertension during pregnancy. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Salzer, Liat; Tenenbaum-Gavish, Kinneret; Hod, Moshe] Helen Schneider Hosp Women, Rabin Med Ctr, IL-49100 Petah Tiqwa, Israel.
   [Salzer, Liat; Tenenbaum-Gavish, Kinneret; Hod, Moshe] Tel Aviv Univ, Sackler Fac Med, IL-69978 Tel Aviv, Israel.
C3 Tel Aviv University; Rabin Medical Center; Tel Aviv University; Sackler
   Faculty of Medicine
RP Hod, M (corresponding author), Helen Schneider Hosp Women, Rabin Med Ctr, Dept Obstet & Gynecol, IL-49100 Petah Tiqwa, Israel.
EM Hodroyal@inter.net.il
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NR 93
TC 47
Z9 50
U1 1
U2 26
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1521-6934
EI 1532-1932
J9 BEST PRACT RES CL OB
JI Best Pract. Res. Clin. Obstet. Gynaecol.
PD APR
PY 2015
VL 29
IS 3
BP 328
EP 338
DI 10.1016/j.bpobgyn.2014.09.008
PG 11
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA CG1ZK
UT WOS:000353074500006
PM 25481558
DA 2025-06-11
ER

PT J
AU Capó, X
   Ferrer, MD
   Olek, RA
   Salaberry, E
   Suau, R
   Marí, B
   Llompart, I
   Tur, JA
   Sureda, A
   Pons, A
AF Capo, Xavier
   Ferrer, Miguel D.
   Olek, Robert A.
   Salaberry, Eduardo
   Suau, Rafael
   Mari, Bartolome
   Llompart, Isabel
   Tur, Josep A.
   Sureda, Antoni
   Pons, Antoni
TI Oral Administration of Sodium Nitrate to Metabolic Syndrome Patients
   Attenuates Mild Inflammatory and Oxidative Responses to Acute Exercise
SO ANTIOXIDANTS
LA English
DT Article
DE exercise; inflammation; metabolic syndrome; nitrate; oxidative stress;
   supplementation
ID DIETARY INORGANIC NITRATE; SKELETAL-MUSCLE ADAPTATIONS; NITRIC-OXIDE;
   RESISTANCE EXERCISE; PHYSICAL-ACTIVITY; ARACHIDONIC-ACID;
   SUPPLEMENTATION; GENERATION; HEALTH; PROSTAGLANDINS
AB The beneficial effects of exercise for the treatment and prevention of metabolic syndrome pathologies have been related to its anti-inflammatory and antioxidant effects. Dietary nitrate supplementation is an emerging treatment strategy to alleviate the symptoms of metabolic syndrome affections and to improve vascular function. In this double-blind crossover trial, metabolic syndrome patients performed two exercise tests for 30 min at 60-70% maximal heart rate after the intake of a placebo or a nitrate-enriched beverage. Acute exercise increased the plasma concentration of TNF alpha, intercellular adhesion molecule ICAM1, PGE1, PGE2 and the newly detected 16-hydroxypalmitic acid (16-HPAL) in metabolic syndrome patients. The cytokine and oxylipin production by peripheral blood mononuclear cells (PBMCs) and neutrophils could be responsible for the plasma concentrations of TNF alpha and IL6, but not for the plasma concentration of oxylipins nor its post-exercise increase. The intake of sodium nitrate 30 min before exercise increased the concentration of nitrate and nitrite in the oral cavity and plasma and reduced the oxygen cost of exercise. Additionally, nitrate intake prevented the enhancing effects of acute exercise on the plasma concentration of TNF alpha, ICAM1, PGE1, PGE2 and 16-HPAL, while reducing the capabilities of PBMCs and neutrophils to produce oxylipins.
C1 [Capo, Xavier; Ferrer, Miguel D.; Salaberry, Eduardo; Tur, Josep A.; Sureda, Antoni; Pons, Antoni] Univ Balearic Isl, Res Grp Community Nutr & Oxidat Stress, Palma De Mallorca 07122, Spain.
   [Capo, Xavier; Tur, Josep A.; Sureda, Antoni; Pons, Antoni] Inst Salud Carlos III, CIBEROBN Fisiopatol Obesidad & Nutr CB12 03 30038, Madrid 28029, Spain.
   [Capo, Xavier; Ferrer, Miguel D.; Salaberry, Eduardo; Llompart, Isabel; Tur, Josep A.; Sureda, Antoni; Pons, Antoni] Hlth Res Inst Balearic Isl IdISBa, Palma De Mallorca 07120, Spain.
   [Capo, Xavier; Ferrer, Miguel D.; Salaberry, Eduardo; Tur, Josep A.; Sureda, Antoni; Pons, Antoni] Univ Balearic Isl, Lab Phys Act Sci, Palma De Mallorca 07122, Spain.
   [Olek, Robert A.] Poznan Univ Phys Educ, Dept Athlet Strength & Conditioning, PL-61871 Poznan, Poland.
   [Suau, Rafael; Mari, Bartolome] Conseil Insular Mallorca, Sports Med Serv, Palma De Mallorca 07010, Spain.
C3 Universitat de les Illes Balears; CIBER - Centro de Investigacion
   Biomedica en Red; CIBEROBN; Instituto de Salud Carlos III; Institut
   Investigacio Sanitaria Illes Balears (IdISBa); Universitat de les Illes
   Balears; Poznan University of Physical Education
RP Pons, A (corresponding author), Univ Balearic Isl, Res Grp Community Nutr & Oxidat Stress, Palma De Mallorca 07122, Spain.; Pons, A (corresponding author), Inst Salud Carlos III, CIBEROBN Fisiopatol Obesidad & Nutr CB12 03 30038, Madrid 28029, Spain.; Pons, A (corresponding author), Hlth Res Inst Balearic Isl IdISBa, Palma De Mallorca 07120, Spain.; Pons, A (corresponding author), Univ Balearic Isl, Lab Phys Act Sci, Palma De Mallorca 07122, Spain.
EM xavier.capo@uib.es; miguel-david.ferrer@uib.es; robert.olek@aol.com;
   edusalaberry@hotmail.com; rsuau@conselldemallorca.net;
   bmari@conselldemallorca.net; isabel.llompart@ssib.es; pep.tur@uib.es;
   antoni.sureda@uib.es; antonipons@uib.es
RI Tur, Josep/AAE-5748-2020; Sureda, Antoni/N-9588-2019; Reynés,
   Miguel/J-4206-2019; Capó, Xavier/AAD-6322-2022; Tur, Josep/F-5576-2014;
   Olek, Robert/H-7206-2019; Pons, Antoni/L-4844-2014
OI Tur, Josep/0000-0002-6940-0761; Olek, Robert/0000-0002-3714-7386; Capo
   Fiol, Xavier/0000-0002-3499-5494; Ferrer, Miguel D./0000-0003-1924-7727;
   , Antoni/0000-0001-8656-6838; Pons, Antoni/0000-0003-2447-3868
FU Spanish Ministry of Economy and Competitiveness, Instituto de Salud
   Carlos III [11/01791, 14/00636, Red Predimed-RETIC RD06/0045/1004,
   CIBEROBN CB12/03/30038]; Government of the Balearic Islands
   [AAEE26/2017]; Health Research Institute of the Balearic Islands
   (IdISBa, PRIMUS Program) [PRI19/10]; European Union FEDER funds; FOLIUM
   programme of IdISBa
FX This work was supported by the Spanish Ministry of Economy and
   Competitiveness, Instituto de Salud Carlos III (Projects 11/01791 and
   14/00636, Red Predimed-RETIC RD06/0045/1004, and CIBEROBN
   CB12/03/30038); Government of the Balearic Islands (grant number
   AAEE26/2017); Health Research Institute of the Balearic Islands (IdISBa,
   PRIMUS Program, grant number PRI19/10) and European Union FEDER funds.
   The funders had no role in study design, data collection and analysis,
   decision to publish, or preparation of the manuscript. X.C. was funded
   by a FOLIUM programme of IdISBa.
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NR 56
TC 8
Z9 9
U1 0
U2 3
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD JUL
PY 2020
VL 9
IS 7
AR 596
DI 10.3390/antiox9070596
PG 17
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA MW6MR
UT WOS:000557148800001
PM 32646062
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Aroor, AR
   Mandavia, CH
   Sowers, JR
AF Aroor, Annayya R.
   Mandavia, Chirag H.
   Sowers, James R.
TI Insulin Resistance and Heart Failure: Molecular Mechanisms
SO HEART FAILURE CLINICS
LA English
DT Article
DE Cardiac insulin resistance; Cardiorenal metabolic syndrome; Heart
   failure; Molecular mechanisms
ID ENDOPLASMIC-RETICULUM STRESS; MUSCLE GLUCOSE-TRANSPORT; OXIDATIVE
   STRESS; MITOCHONDRIAL DYSFUNCTION; RENIN INHIBITION; OBESITY;
   METABOLISM; TARGET; ALDOSTERONE; SENSITIVITY
AB This article addresses the issue of insulin resistance and associated reductions in cardiac insulin metabolic signaling, which is emerging as a major factor in the development of heart failure, and assumes more importance because of an epidemic increase in obesity and the cardiorenal metabolic syndrome in our aging population. The effects of cardiac insulin resistance are exacerbated by metabolic, endocrine, and cytokine alterations associated with systemic insulin resistance. Understanding the molecular mechanisms linking insulin resistance and heart failure may help to design new and more effective mechanism-based drugs to improve myocardial and systemic insulin resistance.
C1 [Aroor, Annayya R.; Mandavia, Chirag H.; Sowers, James R.] Univ Missouri, Sch Med, Dept Internal Med, Columbia, MO 65212 USA.
   [Aroor, Annayya R.; Mandavia, Chirag H.; Sowers, James R.] Univ Missouri, Diabet & Cardiovasc Res Ctr, Sch Med, Columbia, MO 65212 USA.
   [Sowers, James R.] Univ Missouri, Dept Med Pharmacol & Physiol, Sch Med, Columbia, MO 65212 USA.
   [Sowers, James R.] Harry S Truman Mem Vet Hosp, Columbia, MO 65201 USA.
C3 University of Missouri System; University of Missouri Columbia;
   University of Missouri System; University of Missouri Columbia;
   University of Missouri System; University of Missouri Columbia; US
   Department of Veterans Affairs; Veterans Health Administration (VHA);
   Harry S. Truman Memorial Veterans' Hospital
RP Sowers, JR (corresponding author), Univ Missouri, Sch Med, Dept Internal Med, 1 Hosp Dr, Columbia, MO 65212 USA.
EM sowersj@health.missouri.edu
FU NIH [R01 HL73101-01A, R01 HL107910-01]; Veterans Affairs Merit System
   [0018]
FX This research was supported by NIH (R01 HL73101-01A and R01 HL107910-01)
   and the Veterans Affairs Merit System (0018) for JRS.
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NR 55
TC 185
Z9 202
U1 1
U2 31
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1551-7136
J9 HEART FAIL CLIN
JI Heart Fail. Clin.
PD OCT
PY 2012
VL 8
IS 4
BP 609
EP +
DI 10.1016/j.hfc.2012.06.005
PG 10
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 028BF
UT WOS:000310397100011
PM 22999243
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Li, W
   Shi, YH
   Yang, RL
   Cui, J
   Xiao, Y
   Wang, B
   Le, GW
AF Li, Wu
   Shi, Yong-Hui
   Yang, Rui-li
   Cui, Jue
   Xiao, Ying
   Wang, Bin
   Le, Guo-Wei
TI Effect of somatostatin analog on high-fat diet-induced metabolic
   syndrome: Involvement of reactive oxygen species
SO PEPTIDES
LA English
DT Article
DE Somatostatin; Metabolic syndrome; Reactive oxygen species; High-fat diet
ID INCREASED OXIDATIVE STRESS; REGIONAL ADIPOSITY; INSULIN-RESISTANCE;
   RECEPTOR LIGANDS; ABSORPTION; OBESITY; TRIGLYCERIDE; GLUTATHIONE;
   INCREASE; IMPACT
AB Oxidative stress plays an important role in overnutrition-induced metabolic syndrome. Somatostatin (SST) inhibits a wide variety of physiologic functions in the gastrointestinal tract, which may in turn control the levels of reactive oxygen species (ROS) derived from ingestion of macronutrients. In this study, the involvement of SST in the progression of metabolic syndrome in response to a high-fat diet (HFD) was investigated. Male C57BL/6 mice were fed either a normal diet (4.89% fat) or a high-fat diet (21.45% fat) for 4 weeks. The SST analog octreotide (20 mu g/kg/day) was then administered intraperitoneally to half of the HFD mice throughout the 10-day experimental period. Body weight, adipose tissue weight, gastric acidity, total bile acid, and lipase activity were measured. Plasma lipid, glucose, insulin, SST, the levels of ROS and GSH/GSSG, and lipid peroxidation in the stomach, small intestine, pancreas, and liver were also evaluated. Following HFD intake for 38 days, a decrease in the plasma levels of SST and GSH/GSSG ratio was observed, while there was an increase in body weight, adipose tissue weight, plasma glucose, triglyceride, and levels of ROS and lipid peroxidation of the stomach, small intestine, pancreas, and liver. However, simultaneous administration of SST analog octreotide to HFD-fed mice significantly reduced ROS production of the digestive system and resulted in the improvement of all the aforesaid adverse changes, suggesting the involvement of SST in the progression of HFD-induced metabolic syndrome. (C) 2009 Elsevier Inc. All rights reserved.
C1 [Li, Wu; Shi, Yong-Hui; Yang, Rui-li; Cui, Jue; Xiao, Ying; Wang, Bin; Le, Guo-Wei] Jiangnan Univ, State Key Lab Food Sci & Technol, Wuxi 214122, Jiangsu Prov, Peoples R China.
   [Shi, Yong-Hui; Le, Guo-Wei] Jiangnan Univ, Sch Food Sci & Technol, Wuxi 214122, Jiangsu Prov, Peoples R China.
C3 Jiangnan University; Jiangnan University
RP Le, GW (corresponding author), Jiangnan Univ, State Key Lab Food Sci & Technol, 1800 Lihu Rd, Wuxi 214122, Jiangsu Prov, Peoples R China.
EM lgw@jiangnan.edu.cn
RI SHI, YH/HLG-1159-2023; Xiao, Ying/AGM-8681-2022; li, wu/AAG-2304-2020;
   Xiao, Ying/ADV-0522-2022
OI Xiao, Ying/0000-0001-5220-8397; yang, ruili/0000-0001-6347-3196; li,
   wu/0000-0003-3942-0515
FU National Natural Science Foundation of China [30571347]; National Key
   Technology RD Program [2006BAD27806]; State Key Laboratory of Food
   Science and Technology for Oxidant Protein, Wuxi Institute, China
   [200803]
FX This project was supported by the National Natural Science Foundation of
   China (Grant No. 30571347), the National Key Technology R&D Program
   (2006BAD27806), and the State Key Laboratory of Food Science and
   Technology for Oxidant Protein, Wuxi Institute, China (Grant No.
   200803).
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NR 37
TC 24
Z9 26
U1 0
U2 16
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0196-9781
EI 1873-5169
J9 PEPTIDES
JI Peptides
PD APR
PY 2010
VL 31
IS 4
BP 625
EP 629
DI 10.1016/j.peptides.2009.11.008
PG 5
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism;
   Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism;
   Pharmacology & Pharmacy
GA 586FE
UT WOS:000276887600015
PM 19931331
DA 2025-06-11
ER

PT J
AU Casey, DA
   Rodriguez, M
   Northcott, C
   Vickar, G
   Shihabuddin, L
AF Casey, David A.
   Rodriguez, Mercedes
   Northcott, Colleen
   Vickar, Garry
   Shihabuddin, Lina
TI SCHIZOPHRENIA: MEDICAL ILLNESS, MORTALITY, AND AGING
SO INTERNATIONAL JOURNAL OF PSYCHIATRY IN MEDICINE
LA English
DT Article
DE schizophrenia; aging; medical problems
ID METABOLIC SYNDROME; OLDER PATIENTS; CARE; ASSOCIATION; PREVALENCE;
   CANCER; PEOPLE; TRIAL; RISK
AB Objective: Schizophrenia is a devastating and common psychiatric disorder which is associated with a high degree of medical morbidity and reduced life span in addition to psychosis. In this article, these problems will be discussed in the context of schizophrenia and aging. Method: The recent literature was reviewed using Pubmed, Medline, and Google scholar with the search terms "schizophrenia, aging, medical problems." Results: Schizophrenia is associated with significant medical morbidity and mortality. Diabetes and cardiovascular disease, along with smoking and obesity, are over-represented and contribute to reduced quality of life and life span. Schizophrenics often receive poor medical care. Conclusions: The impacts of schizophrenia on physical health and successful aging have been under-estimated. Psychiatrists and primary care physicians need to address the overlapping medical and psychiatric aspects of the disorder while the medical care system for these patients requires a much higher degree of coordination than is currently available. (Int'l. J. Psychiatry in Medicine 2011;41:245-251)
C1 [Casey, David A.] Univ Louisville, Sch Med, Dept Psychiat & Behav Sci, 401 E Chestnut St,Suite 610, Louisville, KY 40202 USA.
   [Rodriguez, Mercedes] VA Healthcare Syst, Miami, FL USA.
   [Northcott, Colleen] Univ British Columbia, Vancouver, BC V5Z 1M9, Canada.
   [Vickar, Garry] Washington Univ, St Louis, MO 63130 USA.
   [Vickar, Garry] St Mathews Univ, Grand Cayman, Cayman Islands.
   [Shihabuddin, Lina] Mt Sinai Sch Med, New York, NY USA.
C3 University of Louisville; University of British Columbia; Washington
   University (WUSTL); Icahn School of Medicine at Mount Sinai
RP Casey, DA (corresponding author), Univ Louisville, Sch Med, Dept Psychiat & Behav Sci, 401 E Chestnut St,Suite 610, Louisville, KY 40202 USA.
EM david.casey@louisville.edu
RI Rodríguez, Mercedes/HTL-9989-2023
CR Bradford DW, 2008, PSYCHIAT SERV, V59, P847, DOI 10.1176/ps.2008.59.8.847
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NR 24
TC 43
Z9 48
U1 0
U2 11
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0091-2174
EI 1541-3527
J9 INT J PSYCHIAT MED
JI Int. J. Psychiatr. Med.
PY 2011
VL 41
IS 3
BP 245
EP 251
DI 10.2190/PM.41.3.c
PG 7
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 829YX
UT WOS:000295624200003
PM 22073763
DA 2025-06-11
ER

PT J
AU Tanacan, E
   Atakan, N
AF Tanacan, Efsun
   Atakan, Nilgun
TI Higher incidence of metabolic syndrome components in vitiligo patients:
   a prospective cross-sectional study
SO ANAIS BRASILEIROS DE DERMATOLOGIA
LA English
DT Article
DE Metabolic syndrome; Obesity; Vitiligo
ID AUTOIMMUNE-DISEASES; PREVALENCE; HOMOCYSTEINE; EPIDEMIOLOGY; PSORIASIS
AB Background/Objectives: To investigate the association between vitiligo and metabolic syndrome.
   Methods: A prospective cross-sectional study was conducted between 2014 and 2016. Study (n=155) and control groups (n=155) were evaluated for metabolic syndrome according to National Cholesterol Education Program Adult Treatment Panel III and the International Diabetes Federation criteria. Study group was divided into three groups according to their vitiligo area severity index and vitiligo disease activity score values (Group 1: 6.89 for VASI score, Group A: -1-0, Group B: 1-2 and Group C: 3-4 for vitiligo disease activity score respectively). MetS rates according to both criteria were compared between the vitiligo disease activity score and vitiligo area severity index groups.
   Results: Metabolic syndrome rates were 37.4% and 40% in the study group and 19.4% and 26.5% in the control group according to National Cholesterol Education Program Adult Treatment Panel III and International Diabetes Federation criteria, respectively (p < 001 and p= 0.011). Metabolic syndrome was more frequent in vitiligo area severity index Groups 2 and 3 compared to vitiligo area severity index Group 1, and in viti lig disease activity score Group C compared to vitiligo disease activity score Groups A and B.
   Study limitations: Single center experience, absence of more specific oxidative-stress markers and lack of long-term follow-up of the patients.
   Conclusions: Frequency of metabolic syndrome was higher in patients with non-segmental vitiligo and the rate was higher in active/severe form of the disease. (C) 2020 Sociedade Brasileira de Dermatologia. Published by Elsevier Espana, S.L.U.
C1 [Tanacan, Efsun] Ufuk Univ, Dept Dermatol & Veneorol, Sch Med, Ankara, Turkey.
   [Atakan, Nilgun] Hacettepe Univ Hosp, Dept Dermatol & Veneorol, Ankara, Turkey.
C3 Ufuk University; Hacettepe University
RP Tanacan, E (corresponding author), Ufuk Univ, Dept Dermatol & Veneorol, Sch Med, Ankara, Turkey.
EM efsunkln@yahoo.com
RI Tanacan, efsun/S-7992-2016
OI Tanacan, Efsun/0000-0003-1975-7460
CR Alikhan A, 2011, J AM ACAD DERMATOL, V65, P473, DOI 10.1016/j.jaad.2010.11.061
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NR 30
TC 34
Z9 35
U1 0
U2 5
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0365-0596
EI 1806-4841
J9 AN BRAS DERMATOL
JI An. Brasil. Dermatol.
PD MAR-APR
PY 2020
VL 95
IS 2
BP 165
EP 172
DI 10.1016/j.abd.2019.07.006
PG 8
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA LF7IK
UT WOS:000527590600005
PM 32113676
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Bouhanick, B
   Ehlinger, V
   Delpierre, C
   Chamontin, B
   Lang, T
   Kelly-Irving, M
AF Bouhanick, Beatrice
   Ehlinger, Virginie
   Delpierre, Cyrille
   Chamontin, Bernard
   Lang, Thierry
   Kelly-Irving, Michelle
TI Mode of delivery at birth and the metabolic syndrome in midlife: the
   role of the birth environment in a prospective birth cohort study
SO BMJ OPEN
LA English
DT Article
ID CESAREAN-SECTION; GUT MICROBIOTA; OBESITY; CHILDHOOD; ASSOCIATION;
   PREVALENCE; MICROFLORA; CHILDREN; WEIGHT; RISK
AB Objectives: The aim of this study is to examine the hypothesis that mode of delivery at birth may be associated with metabolic disorders in adult midlife.
   Setting: Population cohort study
   Participants: The National Child Development Study consists of individuals born during 1 week in 1958 in Great Britain. Respondents with biomedical data on the metabolic syndrome at age 45 were included.
   Outcome measure: The metabolic syndrome was defined based on the National Cholesterol Education Program Adult Treatment Panel (NCEP-ATP) III classification.
   Results: 7156 were born naturally; among the caesarean births, 106 were non-elective and 85 were elective caesareans. The metabolic syndrome is present in 37.7% of those born by non-elective caesareans, 25.9% of those born by elective caesarean and 27.5% of those born by vaginal delivery. In a multivariate logistic regression model adjusted for antenatal factors, birth history, mother's characteristics and the socioeconomic environment at birth, only birth by non-elective caesarean remained associated with the metabolic syndrome in adulthood compared with vaginal delivery (OR 1.51, 95% CI 1.00 to 2.30). Mother's obesity (OR 1.61, 95% CI 1.12 to 2.34) and low maternal education level (OR 1.47, 95% CI 1.30 to 1.67) were also independently associated with midlife metabolic syndrome.
   Conclusions: Birth by non-elective caesarean in 1958 may be associated with metabolic syndrome in adulthood after adjusting for prior confounding factors. We suggest that the birth context of emergency caesareans in 1958 is suggestive of a 'fetal stress' mechanism affecting health across the lifecourse.
C1 [Bouhanick, Beatrice; Chamontin, Bernard] CHU Rangueil, Serv Med Interne & HTA, F-31054 Toulouse, France.
   [Bouhanick, Beatrice; Ehlinger, Virginie; Delpierre, Cyrille; Chamontin, Bernard; Lang, Thierry; Kelly-Irving, Michelle] Fac Med Toulouse, INSERM, UMR 1027, F-31073 Toulouse, France.
   [Ehlinger, Virginie; Delpierre, Cyrille; Lang, Thierry; Kelly-Irving, Michelle] Univ Toulouse 3, UMR1027, F-31062 Toulouse, France.
   [Lang, Thierry] CHU Toulouse, Serv Epidemiol, Toulouse, France.
C3 CHU de Toulouse; Universite de Toulouse; Universite Toulouse III - Paul
   Sabatier; Institut National de la Sante et de la Recherche Medicale
   (Inserm); Universite de Toulouse; Universite Toulouse III - Paul
   Sabatier; Universite de Toulouse; Universite Toulouse III - Paul
   Sabatier; CHU de Toulouse; Universite de Toulouse; Universite Toulouse
   III - Paul Sabatier
RP Bouhanick, B (corresponding author), CHU Rangueil, Serv Med Interne & HTA, F-31054 Toulouse, France.
EM duly-bouhanick.b@chu-toulouse.fr
RI Lang, Thierry/C-1686-2009; Ehlinger, Virginie/MGS-9556-2025; Kelly
   Irving, Michelle/AAA-5052-2022; Kelly-Irving, Michelle/G-3151-2010
OI Kelly-Irving, Michelle/0000-0001-5749-4791; LANG,
   THIERRY/0000-0003-3406-8970; delpierre, cyrille/0000-0002-0831-080X
FU Agence National de Recherche [RPV12021BBA]
FX MKI is funded by the Agence National de Recherche (grant number:
   RPV12021BBA).
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NR 31
TC 16
Z9 17
U1 0
U2 6
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2044-6055
J9 BMJ OPEN
JI BMJ Open
PY 2014
VL 4
IS 5
AR e005031
DI 10.1136/bmjopen-2014-005031
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA AI6IQ
UT WOS:000336976900005
PM 24833693
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Simopoulos, AP
AF Simopoulos, Artemis P.
TI Dietary Omega-3 Fatty Acid Deficiency and High Fructose Intake in the
   Development of Metabolic Syndrome, Brain Metabolic Abnormalities, and
   Non-Alcoholic Fatty Liver Disease
SO NUTRIENTS
LA English
DT Review
DE metabolic syndrome and insulin resistance; dietary omega-3 fatty acid
   deficiency; high fructose intake; non-alcoholic fatty liver disease;
   brain insulin resistance; hippocampus; learning; memory; appetite;
   inflammation; endocannabinoids; neurodegenerative diseases
ID SUGAR-SWEETENED BEVERAGES; ENDOPLASMIC-RETICULUM STRESS; REGULATING
   ENERGY-BALANCE; SOFT DRINK CONSUMPTION; INSULIN-RESISTANCE; HEPATIC
   STEATOSIS; WEIGHT-LOSS; INTRAHEPATIC LIPIDS; HEALTHY AGRICULTURE;
   STEARIDONIC ACID
AB Western diets are characterized by both dietary omega-3 fatty acid deficiency and increased fructose intake. The latter found in high amounts in added sugars such as sucrose and high fructose corn syrup (HFCS). Both a low intake of omega-3 fatty acids or a high fructose intake contribute to metabolic syndrome, liver steatosis or non-alcoholic fatty liver disease (NAFLD), promote brain insulin resistance, and increase the vulnerability to cognitive dysfunction. Insulin resistance is the core perturbation of metabolic syndrome. Multiple cognitive domains are affected by metabolic syndrome in adults and in obese adolescents, with volume losses in the hippocampus and frontal lobe, affecting executive function. Fish oil supplementation maintains proper insulin signaling in the brain, ameliorates NAFLD and decreases the risk to metabolic syndrome suggesting that adequate levels of omega-3 fatty acids in the diet can cope with the metabolic challenges imposed by high fructose intake in Western diets which is of major public health importance. This review presents the current status of the mechanisms involved in the development of the metabolic syndrome, brain insulin resistance, and NAFLD a most promising area of research in Nutrition for the prevention of these conditions, chronic diseases, and improvement of Public Health.
C1 Ctr Genet Nutr & Hlth, Washington, DC 20009 USA.
RP Simopoulos, AP (corresponding author), Ctr Genet Nutr & Hlth, 2001 S St NW,Suite 530, Washington, DC 20009 USA.
EM cgnh@bellatlantic.net
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NR 126
TC 101
Z9 114
U1 1
U2 70
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD AUG
PY 2013
VL 5
IS 8
BP 2901
EP 2923
DI 10.3390/nu5082901
PG 23
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 301GW
UT WOS:000330521800004
PM 23896654
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Jeong, H
   Moon, JE
   Jeon, CH
AF Jeong, Hyemin
   Moon, Ji Eun
   Jeon, Chan Hong
TI Hyperuricemia is Associated With an Increased Prevalence of Metabolic
   Syndrome in a General Population and a Decreased Prevalence of Diabetes
   in Men
SO JOURNAL OF RHEUMATIC DISEASES
LA English
DT Article
DE Uric acid; Metabolic syndrome; Diabetes mellitus
ID SERUM URIC-ACID; CARDIOVASCULAR MORTALITY; ENDOTHELIAL DYSFUNCTION;
   OXIDATIVE STRESS; NATIONAL-HEALTH; RISK; INSULIN; IMPACT; DISEASE;
   GLUCOSE
AB Objective. Elevated uric acid is associated with cardiovascular disease and metabolic syndrome. However, uric acid is also an antioxidant with beneficial effect on comorbidities. The aim of this study was to evaluate the relationship of serum uric acid with diabetes, metabolic syndrome, and cardiovascular disease in a Korean adult population. Methods. A total of 5,887 (weighted n=40,251,868) participants aged >= 19 years from the 2016 Korean National Health and Nutrition Examination Survey were included for analysis. Weighted prevalence and odds ratio (OR) of comorbidities were analyzed according to the presence of hyperuricemia and uric acid quartile. Results. Participants of both sexes with hyperuricemia showed higher prevalence of metabolic syndrome, hypertension, hypertriglyceridemia, and obesity than those without hyperuricemia. After adjusting for socioeconomic and lifestyle characteristics, hyperuricemia was associated with a decreased prevalence of diabetes mellitus in men (OR: 0.44, 95% confidence interval [CI]: 0.28 similar to 0.72, p=0.001) and a decreased prevalence of myocardial infarction or angina (OR: 0.25, 95% CI: 0.08 similar to 0.75, p=0.013) in women. Hyperuricemia was significantly associated with an increased prevalence of metabolic syndrome in both men ( OR: 1.81, 95% CI: 1.33 similar to 2.45, p<0.001) and women (OR: 1.95, 95% CI: 1.22 similar to 3.13, p=0.006). Conclusion. Hyperuricemia was associated with a decreased prevalence of diabetes mellitus in men and a decreased prevalence of myocardial infarction or angina in women. Hyperuricemia was associated with an increased prevalence of metabolic syndrome in both men and women.
C1 [Jeong, Hyemin; Jeon, Chan Hong] Soonchunhyang Univ Hosp Bucheon, Dept Internal Med, Div Rheumatol, 170 Jomaru Ro, Bucheon 14584, South Korea.
   [Moon, Ji Eun] Soonchunhyang Univ Hosp Bucheon, Dept Biostat, Bucheon, South Korea.
C3 Soonchunhyang University; Soonchunhyang University
RP Jeon, CH (corresponding author), Soonchunhyang Univ Hosp Bucheon, Dept Internal Med, Div Rheumatol, 170 Jomaru Ro, Bucheon 14584, South Korea.
EM chjeon@gmail.com
OI Jeon, Chan Hong/0000-0002-2430-7264
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NR 40
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PU KOREAN COLL RHEUMATOLOGY
PI SEOUL
PA RAEMIAN YONGSAN A BLDG 1917, 95 HANGANG-DAERO, YONGSAN-GU,, SEOUL,
   04378, SOUTH KOREA
SN 2093-940X
EI 2233-4718
J9 J RHEUMAT DIS
JI J. Rheum. Dis.
PD OCT
PY 2020
VL 27
IS 4
BP 247
EP 260
DI 10.4078/jrd.2020.27.4.247
PG 14
WC Rheumatology
WE Emerging Sources Citation Index (ESCI)
SC Rheumatology
GA NY5OA
UT WOS:000576437400005
OA gold
DA 2025-06-11
ER

PT J
AU Li, S
   Tan, HZ
   Yang, JR
   Yao, H
   Nie, XK
   Peng, XM
   Liu, QL
   Yang, WY
   Liu, GH
   Nie, QX
   Bian, SG
   Huang, XJ
   Yin, JY
   Cui, SW
   Nie, SP
AF Li, Song
   Tan, Huizi
   Yang, Jingrui
   Yao, Hong
   Nie, Xinke
   Peng, Xiaomao
   Liu, Qionglian
   Yang, Wanyu
   Liu, Guohui
   Nie, Qixing
   Bian, Shuigen
   Huang, Xiaojun
   Yin, Jun-Yi
   Cui, Steve W.
   Nie, Shao-Ping
TI Effects of Three Homogalacturonan-Type Pectins on Mice with Metabolic
   Syndrome
SO JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
LA English
DT Article
DE pectin; metabolic syndrome; gut microbiota; metabolomics;
   structure-function relationship
ID GUT MICROBIOME; DEGRADATION; HOMEOSTASIS; OBESITY; ACID
AB Pectin, a class of dietary fiber, has received increasing attention in recent years for its ameliorative effects on metabolic diseases. However, the structural variability of pectin leads to differential effects on these diseases. The intrinsic mechanism by which pectin, derived from different sources, differentially influences metabolic syndrome by interacting with gut microbiota and host metabolism remains elusive and warrants thorough investigation. To address this, we investigated the effects of HG-type pectins from apple, citrus, and pomelo on phenotypic expressions, inflammatory factors, oxidative stress, and serum hormone levels in mice with metabolic syndrome. In addition, we sought to identify pivotal bacterial species and metabolites by integrating genomics and metabolomics approaches. Our exploration also extended to the relationship between structural characteristics of pectins, gut microbiota, and metabolic syndrome. Our findings revealed that the three pectins diversely improved metabolic syndrome in mice, which correlated with gut microbiota and their beneficial metabolites. Notably, all three pectins were closely associated with Bacteroides and Bacteroides acidifaciens. Besides, the potential mediators of the therapeutic effects included Bacteroides, Lactococcus, and Lachnoclostriclum for apple pectin; Colidextribacter, Bacteroides, Lachnospiraceae_NK4A136_group, and Lachnoclostriclum for citrus pectin; and Lachnospiraceae_NK4A136_group, Bacteroides, and Mucispirillum for pomelo pectin. Metabolites such as arachidonic acid, kynurenic acid, lithocholic acid, deoxycholic acid, and indoleacetic acid, linked to these microbes, may serve as the mediators of pectin's benefits. Ultimately, the molecular weight, degree of esterification, and monosaccharide composition of pectins significantly influenced the outcomes. This study may contribute to a more nuanced understanding that can inform targeted nutritional strategies to modulate gut microbiota for metabolic syndrome management.
C1 [Li, Song; Tan, Huizi; Yang, Jingrui; Yao, Hong; Nie, Xinke; Peng, Xiaomao; Liu, Qionglian; Yang, Wanyu; Liu, Guohui; Nie, Qixing; Bian, Shuigen; Huang, Xiaojun; Yin, Jun-Yi; Cui, Steve W.; Nie, Shao-Ping] Nanchang Univ, State Key Lab Food Sci & Resources, China Canada Joint Lab Food Sci & Technol Nanchang, Key Lab Bioact Polysaccharides Jiangxi Prov, Nanchang 330047, Peoples R China.
   [Cui, Steve W.] Guelph Res & Dev Ctr, Agr & Agrifood Canada, Guelph, ON N1G 5C9, Canada.
C3 Nanchang University; Agriculture & Agri Food Canada
RP Tan, HZ; Nie, SP (corresponding author), Nanchang Univ, State Key Lab Food Sci & Resources, China Canada Joint Lab Food Sci & Technol Nanchang, Key Lab Bioact Polysaccharides Jiangxi Prov, Nanchang 330047, Peoples R China.
EM huizi.tan@ncu.edu.cn; spnie@ncu.edu.cn
RI Tan, Huizi/AAJ-9594-2020; Nie, S/K-1124-2019
FU National Natural Science Foundation of China [2022B0202020004]; Key R&D
   Program of Guangdong Province [20243BCC31003]; Key Research and
   Development Program of Jiangxi Province [32120103012]; National Natural
   Science Foundation of China for the Key Project of International
   Cooperative Research [20244BDF60001, 32330082]; Key Cooperation Project
   on Science and Technology with Developed Countries of Jiangxi Province
   [20212BCD42016]; Key Laboratory of Bioactive Polysaccharides of Jiangxi
   Province
FX This study was supported by the Key R&D Program of Guangdong Province
   (2022B0202020004), the Key Research and Development Program of Jiangxi
   Province (20243BCC31003), the National Natural Science Foundation of
   China for the Key Project of International Cooperative Research
   (32120103012), the Key Cooperation Project on Science and Technology
   with Developed Countries of Jiangxi Province (20244BDF60001), the
   National Natural Science Foundation of China for Key Project (32330082),
   and the Key Laboratory of Bioactive Polysaccharides of Jiangxi Province
   (20212BCD42016).
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NR 50
TC 0
Z9 0
U1 6
U2 6
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0021-8561
EI 1520-5118
J9 J AGR FOOD CHEM
JI J. Agric. Food Chem.
PD MAY 16
PY 2025
VL 73
IS 21
BP 13075
EP 13088
DI 10.1021/acs.jafc.4c11988
EA MAY 2025
PG 14
WC Agriculture, Multidisciplinary; Chemistry, Applied; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture; Chemistry; Food Science & Technology
GA 3EA5K
UT WOS:001490122600001
PM 40376805
DA 2025-06-11
ER

PT J
AU Ibraheem, ZO
   Farhan, SS
   Al Sumaidaee, A
   Al Sufi, L
   Bashir, A
   Balwa, A
   Basir, R
AF Ibraheem, Zaid O.
   Farhan, Sinan Subhi
   Al Sumaidaee, Ajwad
   Al Sufi, Layth
   Bashir, Anas
   Balwa, Anmar
   Basir, Rusliza
TI Liver functions in combined models of the gentamicin induced
   nephrotoxicity and metabolic syndrome induced by high fat or fructose
   diets: a comparative study
SO TOXICOLOGICAL RESEARCH
LA English
DT Article
DE High fat diet; Fructose; Metabolic syndrome; Liver dysfunction and
   oxidative stress
ID INSULIN-RESISTANCE; RAT MODEL; DISEASE; PROGRESSION; ACIDS
AB Metabolic syndrome is one of the major risk factors that lead to various serious complications like cardiovascular abnormalities, hyperlipidemia and diabetes. Its co-incidence with other organs dysfunction results in further deterioration of the condition or precipitation of other dysfunctions. This study aimed at studying the changes in the hepatic functions after the co-incidence of the high fat or fructose diets induced metabolic syndrome along with the gentamicin induced nephrotoxicity. Briefly, six groups of male Sprague Daley rats (n = 10-12) were fed with different feeding protocols; viz; standard rodent's chow, an experimental high fat or high fructose diets feedings. For each, two groups were allocated that one of them was injected with normal saline and the other with 80 mg/kg/day I.P gentamicin during the last 24 days of the feeding period. The rats were monitored for changes in the metabolic data, glycemic control, lipid profile, renal and hepatic functions, oxidative stress and the inflammatory response. The study revealed stronger hepatic changes in the renal failure groups fed with the high fat diet rather than that in the groups fed with the high fructose diet. Although, the latter experienced a stronger deterioration in the glycemic control. The study suggests that the incidence of the hepatic changes is more linked to the incidence of the deterioration in the lipids profile that was observed after the high fat diet feeding. Overall, the co-incidence of the high fat diet induced metabolic syndrome along with the renal failure constitutes a risk factor for the hepatic dysfunction.
C1 [Ibraheem, Zaid O.] Al Rafidain Univ Coll, Dept Pharm, Pharmacol & Toxicol Unit, Baghdad, Iraq.
   [Farhan, Sinan Subhi] Al Rafidain Univ Coll, Dept Pharm, Basic Sci Unit, Baghdad, Iraq.
   [Al Sumaidaee, Ajwad] Baghdad Univ, Fac Pharm, Dept Lab Sci, Baghdad, Iraq.
   [Al Sufi, Layth] Baghdad Univ, Fac Vet Med, Dept Pathol, Baghdad, Iraq.
   [Bashir, Anas] Minist Trade, Qual Control Unit, Baghdad, Iraq.
   [Bashir, Anas; Balwa, Anmar] Al Rafidain Univ Coll, Dept Lab Sci, Baghdad, Iraq.
   [Basir, Rusliza] Univ Putra Malaysia, Pharmacol Unit, Dept Human Anat, Fac Med & Hlth Sci, Serdang 43400, Selangor, Malaysia.
C3 University of Baghdad; University of Baghdad; Universiti Putra Malaysia
RP Ibraheem, ZO (corresponding author), Al Rafidain Univ Coll, Dept Pharm, Pharmacol & Toxicol Unit, Baghdad, Iraq.
EM Zaid.Hussain@ruc.edu.iq
RI Basir, Rusliza/AAP-4070-2021; Abdulkhaleq, Layth
   Abdulmajeed/IQR-6776-2023; Farhan, Sinan Subhi/X-2799-2019
OI bloh, anmar/0000-0001-7219-0315; Abdulkhaleq, Layth
   Abdulmajeed/0000-0003-4365-5560; Ibraaheem, Zaid/0000-0002-9290-0000;
   Farhan, Sinan Subhi/0000-0003-4759-219X
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PU KOREAN SOC TOXICOLOGY
PI Seoul
PA BrownStone Seoul, Bldg 101, Rm 1801, 464, Cheongpa-ro, Jung-gu, Seoul,
   SOUTH KOREA
SN 1976-8257
EI 2234-2753
J9 TOXICOL RES-GER
JI Tox. Research
PD APR
PY 2021
VL 37
IS 2
BP 221
EP 235
DI 10.1007/s43188-020-00059-w
EA OCT 2020
PG 15
WC Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Toxicology
GA RF4WY
UT WOS:000582827100001
PM 33868979
OA Green Published
DA 2025-06-11
ER

PT J
AU Martemucci, G
   Khalil, M
   Di Luca, A
   Abdallah, H
   D'Alessandro, AG
AF Martemucci, Giovanni
   Khalil, Mohamad
   Di Luca, Alessio
   Abdallah, Hala
   D'Alessandro, Angela Gabriella
TI Comprehensive Strategies for Metabolic Syndrome: How Nutrition, Dietary
   Polyphenols, Physical Activity, and Lifestyle Modifications Address
   Diabesity, Cardiovascular Diseases, and Neurodegenerative Conditions
SO METABOLITES
LA English
DT Review
DE metabolic syndrome; diabesity; microbiota; dietary polyphenols; physical
   activity
ID TYPE-2 DIABETES-MELLITUS; VIRGIN OLIVE OIL; HIGH-FAT DIET; MUSCLE
   INSULIN-RESISTANCE; DOSE-RESPONSE METAANALYSIS; INCREASED OXIDATIVE
   STRESS; MILD COGNITIVE IMPAIRMENT; CORONARY-HEART-DISEASE; INDUCED
   WEIGHT-LOSS; WHOLE-GRAIN INTAKE
AB Several hallmarks of metabolic syndrome, such as dysregulation in the glucose and lipid metabolism, endothelial dysfunction, insulin resistance, low-to-medium systemic inflammation, and intestinal microbiota dysbiosis, represent a pathological bridge between metabolic syndrome and diabesity, cardiovascular, and neurodegenerative disorders. This review aims to highlight some therapeutic strategies against metabolic syndrome involving integrative approaches to improve lifestyle and daily diet. The beneficial effects of foods containing antioxidant polyphenols, intestinal microbiota control, and physical activity were also considered. We comprehensively examined a large body of published articles involving basic, animal, and human studie, as well as recent guidelines. As a result, dietary polyphenols from natural plant-based antioxidants and adherence to the Mediterranean diet, along with physical exercise, are promising complementary therapies to delay or prevent the onset of metabolic syndrome and counteract diabesity and cardiovascular diseases, as well as to protect against neurodegenerative disorders and cognitive decline. Modulation of the intestinal microbiota reduces the risks associated with MS, improves diabetes and cardiovascular diseases (CVD), and exerts neuroprotective action. Despite several studies, the estimation of dietary polyphenol intake is inconclusive and requires further evidence. Lifestyle interventions involving physical activity and reduced calorie intake can improve metabolic outcomes.
C1 [Martemucci, Giovanni] Univ Bari Aldo Moro, I-70126 Bari, Italy.
   [Khalil, Mohamad; Abdallah, Hala] Univ Bari, Dept Precis & Regenerat Med, Clin Med A Murri, Med Sch, I-70121 Bari, Italy.
   [Di Luca, Alessio; D'Alessandro, Angela Gabriella] Univ Bari Aldo Moro, Dept Soil Plant & Food Sci, I-70126 Bari, Italy.
C3 Universita degli Studi di Bari Aldo Moro; Universita degli Studi di Bari
   Aldo Moro; Universita degli Studi di Bari Aldo Moro
RP Khalil, M (corresponding author), Univ Bari, Dept Precis & Regenerat Med, Clin Med A Murri, Med Sch, I-70121 Bari, Italy.
EM gmartem@libero.it; mohamad.khalil@uniba.it; alessio.diluca@uniba.it;
   halaabdallah18@gmail.com; angelagabriella.dalessandro@uniba.it
RI Di Luca, Alessio/LRT-9473-2024; D'Alessandro, Angela/AAN-9075-2020
OI D'Alessandro, Angela Gabriella/0000-0002-1506-5427
FU European Regional Development 1031 Fund (ERDF)-INNO.TRITION [5003778]
FX This research was part of the Innovation and Competitiveness Cooperation
   Programme 1030 Interreg V/A Greece-Italy (EL-IT) 2014-2020, Co-financed
   by the European Regional Development 1031 Fund (ERDF)-INNO.TRITION (Mis.
   Code: 5003778).
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   Sharma, JP
   Ostojic, SM
   Gvozdjakova, A
   Kura, B
   Noda, M
   Mojto, V
   Niaz, MA
   Slezak, J
AF LeBaron, Tyler W.
   Singh, Ram B.
   Fatima, Ghizal
   Kartikey, Kumar
   Sharma, Jagdish P.
   Ostojic, Serge M.
   Gvozdjakova, Anna
   Kura, Branislav
   Noda, Mami
   Mojto, Viliam
   Niaz, Mohammad Arif
   Slezak, Jan
TI The Effects of 24-Week, High-Concentration Hydrogen-Rich Water on Body
   Composition, Blood Lipid Profiles and Inflammation Biomarkers in Men and
   Women with Metabolic Syndrome: A Randomized Controlled Trial
SO DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
LA English
DT Article
DE metabolism; fasting blood glucose; cholesterol; inflammation; oxidative
   stress; hydrogen water
ID MOLECULAR-HYDROGEN; DISEASE; ATHEROSCLEROSIS; ANTIOXIDANT; MODEL; DIET
AB Purpose: Metabolic syndrome is associated with several medical risk factors including dyslipidemia, hyperglycemia, and obesity, which has become a worldwide pandemic. The sequelae of this condition increase the risk of cardiovascular and neurological disease and increased mortality. Its pathophysiology is associated with redox dysregulation, excessive inflammation, and perturbation of cellular homeostasis. Molecular hydrogen (H-2) may attenuate oxidative stress, improve cellular function, and reduce chronic inflammation. Pre-clinical and clinical studies have shown promising effects of H-2-rich water (HRW) on specific features of metabolic syndrome, yet the effects of long-term, high-concentration HRW in this prevalent condition remain poorly addressed.
   Methods: We conducted a randomized, double-blinded, placebo-controlled trial in 60 subjects (30 men and 30 women) with metabolic syndrome. An initial observation period of one week was used to acquire baseline clinical data followed by randomization to either placebo or high-concentration HRW (> 5.5 millimoles of H-2 per day) for 24 weeks.
   Results: Supplementation with high-concentration HRW significantly reduced blood cholesterol and glucose levels, attenuated serum hemoglobin A1c, and improved biomarkers of inflammation and redox homeostasis as compared to placebo (P < 0.05). Furthermore, H-2 tended to promote a mild reduction in body mass index and waist-to-hip ratio.
   Conclusion: Our results give further credence that high-concentration HRW might have promising effects as a therapeutic modality for attenuating risk factors of metabolic syndrome.
C1 [LeBaron, Tyler W.; Slezak, Jan] Slovak Acad Sci, Ctr Expt Med, Inst Heart Res, Dubravska Cesta 9, Bratislava 84104, Slovakia.
   [LeBaron, Tyler W.; Kura, Branislav] Mol Hydrogen Inst, Enoch, UT USA.
   [Singh, Ram B.; Kartikey, Kumar; Sharma, Jagdish P.] Hosp & Res Inst, Moradabad, India.
   [Fatima, Ghizal] Era Med Coll, Lucknow, Uttar Pradesh, India.
   [Ostojic, Serge M.] Univ Novi Sad, Fac Sport & PE, Appl Bioenerget Lab, Novi Sad, Serbia.
   [Ostojic, Serge M.] Univ Pecs, Fac Hlth Sci, Pecs, Hungary.
   [Gvozdjakova, Anna] Comenius Univ, Med Dept 3, Pharmacobiochem Lab, Med Fac, Bratislava, Slovakia.
   [Noda, Mami] Kyushu Univ, Grad Sch Pharmaceut Sci, Lab Pathophysiol, Fukuoka, Japan.
   [Mojto, Viliam] Comenius Univ, Fac Med, Internal Clin 3, Bratislava, Slovakia.
   [Niaz, Mohammad Arif] Int Coll Nutr, Ctr Nutr Res, Moradabad, India.
C3 Slovak Academy of Sciences; Centre of Experimental Medicine, SAS;
   Institute for Heart Research, SAS; University of Novi Sad; University of
   Pecs; Comenius University Bratislava; Kyushu University; Comenius
   University Bratislava
RP Slezak, J (corresponding author), Slovak Acad Sci, Ctr Expt Med, Inst Heart Res, Dubravska Cesta 9, Bratislava 84104, Slovakia.
EM jan.slezak@savba.sk
RI Noda, Mami/AAC-3949-2020; LeBaron, Tyler/GLT-7071-2022; Singh,
   Satbeer/AAJ-6786-2021; Stefanadis, Christodoulos/ABH-2232-2020
OI LeBaron, Tyler/0000-0001-9164-6728; Noda, Mami/0000-0002-9674-069X;
   Stefanadis, Christodoulos/0000-0001-5974-6454
FU Slovak Research and Development Agency [(APVV)-0241-11, APVV-15-0376];
   ITMS [26230120009]; Scientific grant agency of the Ministry of Education
   of the Slovak Republic (VEGA) [2/0063/18]; HRW Natural Health Products
   Inc.
FX This study was partially supported by Slovak Research and Development
   Agency (APVV)-0241-11, APVV-15-0376; ITMS 26230120009; Scientific grant
   agency of the Ministry of Education of the Slovak Republic (VEGA)
   2/0063/18, and by HRW Natural Health Products Inc.
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NR 39
TC 55
Z9 58
U1 4
U2 20
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-7007
J9 DIABETES METAB SYNDR
JI Diabetes Metab. Syndr. Obes.
PY 2020
VL 13
BP 889
EP 896
DI 10.2147/DMSO.S240122
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA KX0AA
UT WOS:000521544800001
PM 32273740
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Gray, MA
   Taggart, P
   Sutton, PM
   Groves, D
   Holdright, DR
   Bradbury, D
   Brull, D
   Critchley, HD
AF Gray, Marcus A.
   Taggart, Peter
   Sutton, Peter M.
   Groves, David
   Holdright, Diana R.
   Bradbury, David
   Brull, David
   Critchley, Hugo D.
TI A cortical potential reflecting cardiac function
SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF
   AMERICA
LA English
DT Article
DE afferent homeostatic feedback; electroencephalography; heart beat-evoked
   potential; insula cortex; ischemia
ID INSULAR CORTEX STIMULATION; INTEROCEPTIVE AWARENESS; MENTAL STRESS;
   SUDDEN-DEATH; PHYSIOLOGICAL CONDITION; MYOCARDIAL-INFARCTION;
   MAGNETIC-RESONANCE; RESTING HUMANS; SYNDROME-X; T-WAVE
AB Emotional trauma and psychological stress can precipitate cardiac arrhythmia and sudden death through arrhythmogenic effects of efferent sympathetic drive. Patients with preexisting heart disease are particularly at risk. Moreover, generation of proarrhythmic activity patterns within cerebral autonomic centers may be amplified by afferent feedback from a dysfunctional myocardium. An electrocortical potential reflecting afferent cardiac information has been described, reflecting individual differences in interoceptive sensitivity (awareness of one's own heartbeats). To inform our understanding of mechanisms underlying arrhythmogenesis, we extended this approach, identifying electrocortical potentials corresponding to the cortical expression of afferent information about the integrity of myocardial function during stress. We measured changes in cardiac response simultaneously with electroencephalography in patients with established ventricular dysfunction. Experimentally induced mental stress enhanced cardiovascular indices of sympathetic activity (systolic blood pressure, heart rate, ventricular ejection fraction, and skin conductance) across all patients. However, the functional response of the myocardium varied; some patients increased, whereas others decreased, cardiac output during stress. Across patients, heartbeat-evoked potential amplitude at left temporal and lateral frontal electrode locations correlated with stress-induced changes in cardiac output, consistent with an afferent cortical representation of myocardial function during stress. Moreover, the amplitude of the heartbeat-evoked potential in the left temporal region reflected the proarrhythmic status of the heart (inhomogeneity of left ventricular repolarization). These observations delineate a cortical representation of cardiac function predictive of proarrhythmic abnormalities in cardiac repolarization. Our findings highlight the dynamic interaction of heart and brain in stress-induced cardiovascular morbidity.
C1 UCL, Inst Neurol, Wellcome Dept Imaging Neurosci, Funct Imaging Lab, London WC1N 3BG, England.
   Royal Free & Univ Coll, Sch Med, Div Med, Hatter Cardiovasc Inst, London WC1E 6HX, England.
   Royal Liverpool & Broadgreen Univ Hosp NHS Trust, Natl Refractory Angina Ctr, Liverpool L14 3PE, Merseyside, England.
   UCL Hosp, Heart Hosp, London W1G 8PH, England.
   Whittington Hosp NHS Trust Hosp, London N19 5NF, England.
   Univ Sussex, Brighton & Sussex Med Sch, Dept Psychiat, Brighton BN1 6PX, E Sussex, England.
C3 University of London; University College London; University of London;
   University College London; UCL Medical School; Royal Liverpool &
   Broadgreen University Hospitals NHS Trust; Royal Liverpool University
   Hospital; University College London Hospitals NHS Foundation Trust; The
   Heart Hospital; University of London; University College London;
   University of Sussex; University of Brighton
RP Gray, MA (corresponding author), UCL, Inst Neurol, Wellcome Dept Imaging Neurosci, Funct Imaging Lab, 12 Queen Sq, London WC1N 3BG, England.
EM M.A.Gray@bsms.ac.uk
RI critchley, hugo/G-9267-2011; Gray, Marcus/F-6521-2013
OI critchley, hugo/0000-0002-2445-9284; Gray, Marcus/0000-0001-8671-6939
FU Wellcome Trust Funding Source: Medline
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NR 59
TC 162
Z9 170
U1 2
U2 40
PU NATL ACAD SCIENCES
PI WASHINGTON
PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA
SN 0027-8424
J9 P NATL ACAD SCI USA
JI Proc. Natl. Acad. Sci. U. S. A.
PD APR 17
PY 2007
VL 104
IS 16
BP 6818
EP 6823
DI 10.1073/pnas.0609509104
PG 6
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 159ME
UT WOS:000245869200059
PM 17420478
OA Green Published
DA 2025-06-11
ER

PT J
AU Fransson, L
   Franzén, S
   Rosengren, V
   Wolbert, P
   Sjöholm, Å
   Ortsäter, H
AF Fransson, Liselotte
   Franzen, Stephanie
   Rosengren, Victoria
   Wolbert, Petra
   Sjoholm, Ake
   Ortsater, Henrik
TI β-cell adaptation in a mouse model of glucocorticoid-induced metabolic
   syndrome
SO JOURNAL OF ENDOCRINOLOGY
LA English
DT Article
DE glucocorticoid; diabetes; insulin secretion; obesity; islet cells
ID ENDOPLASMIC-RETICULUM STRESS; BODY-FAT DISTRIBUTION; CORTISOL SECRETION;
   ENDOCRINE PANCREAS; ABDOMINAL OBESITY; DEXAMETHASONE; MECHANISMS;
   GLUCOSE; MICE; CORTICOSTERONE
AB Glucocorticoids (GCs) are stress hormones primarily responsible for mobilizing glucose to the circulation. Due to this effect, insulin resistance and glucose intolerance are concerns in patients with endogenous overproduction of GCs and in patients prescribed GC-based therapy. In addition, hypercortisolemic conditions share many characteristics with the metabolic syndrome. This study reports on a thorough characterization, in terms of glucose control and lipid handling, of a mouse model where corticosterone is given via the drinking water. C57BL/6J mice were treated with corticosterone (100 or 25 mu g/ml) or vehicle in their drinking water for 5 weeks after which they were subjected to insulin or glucose tolerance tests. GC-treated mice displayed increased food intake, body weight gain, and central fat deposit accumulations. In addition, the GC treatment led to dyslipidemia as well as accumulation of ectopic fat in the liver and skeletal muscle, having a substantial negative effect on insulin sensitivity. Also glucose intolerance and hypertension, both part of the metabolic syndrome, were evident in the GC-treated mice. However, the observed effects of corticosterone were reversed after drug removal. Furthermore, this study reveals insights into beta-cell adaptation to the GC-induced insulin resistance. Increased pancreatic islet volume due to cell proliferation, increased insulin secretion capacity, and increased islet chaperone expression were found in GC-treated animals. This model mimics the human metabolic syndrome. It could be a valuable model for studying the complex mechanisms behind the development of the metabolic syndrome and type 2 diabetes, as well as the multifaceted relations between GC excess and disease.
C1 [Fransson, Liselotte; Rosengren, Victoria; Wolbert, Petra; Sjoholm, Ake; Ortsater, Henrik] Soder Sjukhuset, Karolinska Inst, Dept Clin Sci & Educ, SE-11883 Stockholm, Sweden.
   [Franzen, Stephanie] Linkoping Univ, Dept Med & Hlth Sci, Div Drug Res Expt Renal Med, SE-58183 Linkoping, Sweden.
   [Franzen, Stephanie] Linkoping Univ, Ctr Med Image Sci & Visualizat, SE-58183 Linkoping, Sweden.
   [Sjoholm, Ake] Univ S Alabama, Dept Biochem & Mol Biol, Coll Med, Mobile, AL 36688 USA.
C3 Karolinska Institutet; Sodersjukhuset Hospital; Linkoping University;
   Linkoping University; University of South Alabama
RP Ortsäter, H (corresponding author), Soder Sjukhuset, Karolinska Inst, Dept Clin Sci & Educ, SE-11883 Stockholm, Sweden.
EM henrik.ortsater@ki.se
RI Franzén, Stephanie/AAF-8180-2021
OI Sjoholm, Ake/0000-0002-5274-9748; Bjorsson,
   Liselotte/0000-0002-2957-5161; Franzen, Stephanie/0000-0002-5003-2508
FU Diabetes Research and Wellness Foundation; Swedish Diabetes Foundation
   (Diabetesfonden); Tore Nilsson Foundation; Swedish Society for Medical
   Research; KID (Karolinska Institutet)
FX This study was supported by grants from the Diabetes Research and
   Wellness Foundation, Swedish Diabetes Foundation (Diabetesfonden) and
   the Tore Nilsson Foundation. H Ortsater is funded by the Swedish Society
   for Medical Research. L Fransson is partly funded by KID (Karolinska
   Institutet, Faculty funds for partial funding of doctoral students).
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NR 51
TC 44
Z9 51
U1 0
U2 11
PU BIOSCIENTIFICA LTD
PI BRISTOL
PA EURO HOUSE, 22 APEX COURT WOODLANDS, BRADLEY STOKE, BRISTOL BS32 4JT,
   ENGLAND
SN 0022-0795
EI 1479-6805
J9 J ENDOCRINOL
JI J. Endocrinol.
PD DEC
PY 2013
VL 219
IS 3
BP 231
EP 241
DI 10.1530/JOE-13-0189
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 262TU
UT WOS:000327761300005
PM 24048967
OA Bronze
DA 2025-06-11
ER

PT J
AU Rizzo, M
   Nikolic, D
   Patti, AM
   Mannina, C
   Montalto, G
   McAdams, BS
   Rizvi, AA
   Cosentino, F
AF Rizzo, Manfredi
   Nikolic, Dragana
   Patti, Angelo Maria
   Mannina, Carlo
   Montalto, Giuseppe
   McAdams, Brooke S.
   Rizvi, Ali A.
   Cosentino, Francesco
TI GLP-1 receptor agonists and reduction of cardiometabolic risk: Potential
   underlying mechanisms
SO BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
LA English
DT Review
DE Cardiometabolic parameters; Cardiovascular risk; Glucagon-like peptide 1
   receptor agonists; Type 2 diabetes mellitus
ID ONCE-WEEKLY DULAGLUTIDE; TYPE-2 DIABETES-MELLITUS; INCRETIN-BASED
   THERAPIES; CARDIOVASCULAR OUTCOMES; GLYCEMIC CONTROL; OPEN-LABEL;
   METABOLIC SYNDROME; DAILY LIRAGLUTIDE; EXENATIDE EXERTS; PEPTIDE-1
   ANALOG
AB Type 2 diabetes mellitus (T2DM) is a metabolic condition with an elevated impact on cardiovascular (CV) risk. The innovative therapeutic approaches for T2DM - incretin-based therapies (IBTs), including glucagon-like peptide 1 (GLP-1) receptor agonists, have become popular and more widely used in recent years. The available scientific data from clinical studies and clinical practice highlights their beyond glucose-lowering effects, which is achieved without any increase in hypoglycaemia. The former effects include reduction in body weight, lipids, blood pressure, inflammatory markers, oxidative stress, endothelial dysfunction, and subclinical atherosclerosis, thus reducing and potentially preventing CV events. In fact, the introduction of IBTs is one of the key moments in the history of diabetes research and treatment. Such therapeutic strategies allow customization of antidiabetic treatment to each patient's need and therefore obtain better metabolic control with reduced CV risk. The aim of the present paper is to provide a comprehensive overview of the effects of GLP-1RA on various cardiometabolic markers and overall CV risk, with particular attention on recent CV outcome studies and potential mechanisms. In particular, the effects of liraglutide on formation and progression of atherosclerotic plaque and mechanisms explaining its cardioprotective effects are highlighted.
C1 [Rizzo, Manfredi; Nikolic, Dragana; Patti, Angelo Maria; Mannina, Carlo; Montalto, Giuseppe] Univ Palermo, Biomed Dept Internal Med & Med Specialties, Via Vespro 141, I-90127 Palermo, Italy.
   [Rizzo, Manfredi; McAdams, Brooke S.; Rizvi, Ali A.] Univ South Carolina, Sch Med, Div Endocrinol Diabet & Metab, Columbia, SC 29203 USA.
   [Cosentino, Francesco] Karolinska Inst, Dept Med, Unit Cardiol, S1 02, S-17176 Stockholm, Sweden.
   [Cosentino, Francesco] Karolinska Univ Hosp Solna, S1 02, S-17176 Stockholm, Sweden.
C3 University of Palermo; University of South Carolina System; University
   of South Carolina Columbia; Karolinska Institutet; Karolinska
   Institutet; Karolinska University Hospital
RP Rizzo, M (corresponding author), Univ Palermo, Biomed Dept Internal Med & Med Specialties, Via Vespro 141, I-90127 Palermo, Italy.
EM manfredi.rizzo@unipa.it; giuseppe.montalto@unipa.it;
   ali.rizvi@uscmed.sc.edu; francesco.cosentino@ki.se
RI Rizvi, Ali/AFV-2240-2022; Cosentino, Francesco/AAE-2426-2020; RIZZO,
   MANFREDI/GZL-0551-2022; Licata, Anna/ADF-0000-2022
OI Mannina, Carlo/0000-0003-1324-1869; Nikolic, Dragana/0000-0001-9572-9651
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NR 77
TC 111
Z9 115
U1 0
U2 10
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0925-4439
EI 1879-260X
J9 BBA-MOL BASIS DIS
JI Biochim. Biophys. Acta-Mol. Basis Dis.
PD SEP
PY 2018
VL 1864
IS 9
BP 2814
EP 2821
DI 10.1016/j.bbadis.2018.05.012
PN B
PG 8
WC Biochemistry & Molecular Biology; Biophysics; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Cell Biology
GA GQ8ZR
UT WOS:000442056200006
PM 29778663
DA 2025-06-11
ER

PT J
AU de Azua, IR
   Lutz, B
AF de Azua, Inigo Ruiz
   Lutz, Beat
TI Multiple endocannabinoid-mediated mechanisms in the regulation of energy
   homeostasis in brain and peripheral tissues
SO CELLULAR AND MOLECULAR LIFE SCIENCES
LA English
DT Review
DE Endocannabinoid system; 2-Arachidonoyl glycerol; Anandamide; Cannabinoid
   type 1 receptor; Energy balance; Energy expenditure; Feeding behaviour;
   Rimonabant; Peripheral CB1 antagonist; Obesity; Type-2 diabetes;
   Metabolic syndrome
ID CB1 CANNABINOID RECEPTOR; FABP1 GENE ABLATION; ALTERNATIVELY ACTIVATED
   MACROPHAGES; ENDOPLASMIC-RETICULUM STRESS; IMPROVES INSULIN SENSITIVITY;
   CARDIOMETABOLIC RISK-FACTORS; NUCLEUS-ACCUMBENS SHELL; WHITE
   ADIPOSE-TISSUE; FATTY LIVER-DISEASE; FOOD-INTAKE
AB The endocannabinoid (eCB) system is widely expressed in many central and peripheral tissues, and is involved in a plethora of physiological processes. Among these, activity of the eCB system promotes energy intake and storage, which, however, under pathophysiological conditions, can favour the development of obesity and obesity-related disorders. It is proposed that eCB signalling is evolutionary beneficial for survival under periods of scarce food resources. Remarkably, eCB signalling is increased both in hunger and in overnutrition conditions, such as obesity and type-2 diabetes. This apparent paradox suggests a role of the eCB system both at initiation and at clinical endpoint of obesity. This review will focus on recent findings about the role of the eCB system controlling whole-body metabolism in mice that are genetically modified selectively in different cell types. The current data in fact support the notion that eCB signalling is not only engaged in the development but also in the maintenance of obesity, whereby specific cell types in central and peripheral tissues are key sites in regulating the entire body's energy homeostasis.
C1 [de Azua, Inigo Ruiz; Lutz, Beat] Johannes Gutenberg Univ Mainz, Univ Med Ctr, German Resilience Ctr DRZ, Duesbergweg 5, D-55128 Mainz, Germany.
   [de Azua, Inigo Ruiz; Lutz, Beat] Johannes Gutenberg Univ Mainz, Univ Med Ctr, Inst Physiol Chem, Duesbergweg 5, D-55128 Mainz, Germany.
C3 Johannes Gutenberg University of Mainz; Johannes Gutenberg University of
   Mainz
RP de Azua, IR (corresponding author), Johannes Gutenberg Univ Mainz, Univ Med Ctr, German Resilience Ctr DRZ, Duesbergweg 5, D-55128 Mainz, Germany.; de Azua, IR (corresponding author), Johannes Gutenberg Univ Mainz, Univ Med Ctr, Inst Physiol Chem, Duesbergweg 5, D-55128 Mainz, Germany.
EM inigo.azua@drz-mainz.de
RI Lutz, Beat/AFK-6229-2022
FU Boehringer Ingelheim Foundation
FX I. R. de A. was partly funded the Boehringer Ingelheim Foundation.
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NR 224
TC 62
Z9 64
U1 0
U2 15
PU SPRINGER BASEL AG
PI BASEL
PA PICASSOPLATZ 4, BASEL, 4052, SWITZERLAND
SN 1420-682X
EI 1420-9071
J9 CELL MOL LIFE SCI
JI Cell. Mol. Life Sci.
PD APR
PY 2019
VL 76
IS 7
BP 1341
EP 1363
DI 10.1007/s00018-018-2994-6
PG 23
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA HP0YN
UT WOS:000461392600007
PM 30599065
OA Green Published
DA 2025-06-11
ER

PT J
AU Corina, A
   Abrudan, MB
   Nikolic, D
   Catoi, AF
   Chianetta, R
   Castellino, G
   Citarrella, R
   Stoian, AP
   Pérez-Martínez, P
   Rizzo, M
AF Corina, Andreea
   Abrudan, Maria B.
   Nikolic, Dragana
   Catoi, Adriana F.
   Chianetta, Roberta
   Castellino, Giuseppa
   Citarrella, Roberto
   Stoian, Anca P.
   Perez-Martinez, Pablo
   Rizzo, Manfredi
TI Effects of Aging and Diet on Cardioprotection and Cardiometabolic Risk
   Markers
SO CURRENT PHARMACEUTICAL DESIGN
LA English
DT Review
DE Aging; diet; cardioprotection; cardiovascular risk; diabetes; metabolic
   syndrome; nutraceuticals
ID LEUKOCYTE TELOMERE LENGTH; CARDIOVASCULAR-DISEASE RISK; DOSE-RESPONSE
   METAANALYSIS; CORONARY-HEART-DISEASE; VIRGIN OLIVE OIL; CALORIC
   RESTRICTION; MEDITERRANEAN DIET; LIFE-STYLE; ALCOHOL-CONSUMPTION;
   ATRIAL-FIBRILLATION
AB The prevalence of several diseases increases by age, including cardiovascular diseases, which are the leading cause of morbidity and mortality worldwide. Aging, as a complex process characterized by senescence, triggers various pathways, such as oxidative stress, systemic inflammation, metabolism dysfunction, telomere shortening, mitochondrial dysfunction and deregulated autophagy. A better understanding of the mechanisms underlying senescence may lead to the development of new therapeutic targets and strategies for age-related pathologies and extend the healthy lifespan. Modulating lifestyle risk factors and adopting healthy dietary patterns remain significant tools in delaying the aging process, decreasing age-associated comorbidities and mortality, increasing life expectancy and consequently, preventing the development of cardiovascular disease. Furthermore, such a strategy represents the most cost-effective approach, and the quality of life of the subjects may be significantly improved. An integrated, personalized approach targeting cardiometabolic aging and frailty is suggested in daily clinical practice. However, it should be initiated from an early age. Moreover, there is a need for further well designed and controlled studies in order to elucidate a link between the time of feeding, longevity and cardiovascular prevention. In the future, it is expected that the pharmacological treatment in cardioprotective management will be necessary, accompanied by equally important lifestyle interventions and adjunctive exercise.
C1 [Corina, Andreea; Perez-Martinez, Pablo] Univ Cordoba, Reina Sofia Univ Hosp, Maimonides Biomed Res Inst Cordoba IMIBIC, Lipids & Atherosclerosis Res Unit, Cordoba, Spain.
   [Corina, Andreea; Perez-Martinez, Pablo] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr CIBEROBN, Cordoba, Spain.
   [Abrudan, Maria B.] Iuliu Hatieganu Univ Med & Pharm, Fac Pharm, Dept Pharmaceut Technol & Biopharmaceut, Cluj Napoca, Romania.
   [Nikolic, Dragana; Chianetta, Roberta; Castellino, Giuseppa; Citarrella, Roberto; Rizzo, Manfredi] Univ Palermo, PROMISE Dept, Via Vespro 141, I-90127 Palermo, Italy.
   [Nikolic, Dragana; Chianetta, Roberta; Castellino, Giuseppa] Euromediterranean Inst Sci & Technol IEMEST, Palermo, Italy.
   [Catoi, Adriana F.] Iuliu Hatieganu Univ Med & Pharm, Pathophysiol Dept, Cluj Napoca, Romania.
   [Stoian, Anca P.] Carol Davila Univ Med & Pharm, Dept Diabet Nutr & Metab Dis, Bucharest, Romania.
C3 Universidad de Cordoba; Instituto de Salud Carlos III; CIBER - Centro de
   Investigacion Biomedica en Red; CIBEROBN; Iuliu Hatieganu University of
   Medicine & Pharmacy; University of Palermo; Iuliu Hatieganu University
   of Medicine & Pharmacy; Carol Davila University of Medicine & Pharmacy
RP Nikolic, D (corresponding author), Univ Palermo, PROMISE Dept, Via Vespro 141, I-90127 Palermo, Italy.
EM draggana.nikolic@gmail.com
RI RIZZO, MANFREDI/GZL-0551-2022; Castellino, Giuseppa/AAF-4272-2020; Perez
   Martinez, Pablo/AEL-6176-2022; Brundel, Bianca/D-2318-2016; Pantea
   Stoian, Anca/H-5799-2017
OI Nikolic, Dragana/0000-0001-9572-9651; Perez Martinez,
   Pablo/0000-0001-7716-8117; Brundel, Bianca/0000-0002-4768-234X; RIZZO,
   Manfredi/0000-0002-9549-8504; Pantea Stoian, Anca/0000-0003-0555-526X;
   Chianetta, Roberta/0009-0001-3855-0206
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NR 139
TC 12
Z9 12
U1 1
U2 11
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1381-6128
EI 1873-4286
J9 CURR PHARM DESIGN
JI Curr. Pharm. Design
PY 2019
VL 25
IS 35
BP 3704
EP 3714
DI 10.2174/1381612825666191105111232
PG 11
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Pharmacology & Pharmacy
GA JV4IJ
UT WOS:000502328500002
PM 31692432
DA 2025-06-11
ER

PT J
AU Kim, J
   Choi, YH
AF Kim, Junghoon
   Choi, Yoon-Hyeong
TI Physical activity, dietary vitamin C, and metabolic syndrome in the
   Korean adults: the Korea National Health and Nutrition Examination
   Survey 2008 to 2012
SO PUBLIC HEALTH
LA English
DT Article
DE Metabolic syndrome; Physical activity; Antioxidants; Dietary intake
ID ANTIOXIDANT STATUS; OXIDATIVE STRESS; US ADULTS; FOLLOW-UP; ASSOCIATION;
   OBESITY; SERUM; RISK; INTERVENTION; CAROTENOIDS
AB Objectives: Metabolic syndrome is a global public health problem, and regular physical activity is a well-known critical factor in its management. A recent study suggests that the effect of exercise on metabolic syndrome may be enhanced by sufficient plasma vitamin C concentrations. We therefore examined the combined effect of physical activity and dietary vitamin C on the risk of metabolic syndrome in the general Korean population.
   Study design: Cross-sectional study.
   Methods: We analyzed data from 22,671 adults aged 20 years or older from the Korea National Health and Nutrition Examination Survey 2008-2012. Physical activity was computed as the total metabolic equivalent (METs-hr/week) summed from MET scores of walking, moderate activity, and vigorous activity. Vitamin C intake was assessed using a 24-h dietary recall. Participants were classified into four combined groups based on median values of physical activity and vitamin C intake.
   Results: After adjustment for potential confounders, the odds ratio (OR) for metabolic syndrome in individuals with both high physical activity and vitamin C intake (vs. both low physical activity and vitamin C intake) was 0.79 (95% confidence interval (CI), 0.71-0.87). The estimated combined effect was more than either high physical activity alone (OR, 0.81 (95% CI, 0.73-0.90)) or high vitamin C intake alone (OR, 0.89 (95% CI, 0.80-0.99)), although each of those was beneficial.
   Conclusions: Physical activity and dietary intake of vitamin C are both associated with a lower risk of metabolic syndrome. Our findings suggest further that a combination of physical activity and a diet rich in vitamin C may help in preventing metabolic syndrome. (C) 2016 The Royal Society for Public Health. Published by Elsevier Ltd. All rights reserved.
C1 [Kim, Junghoon; Choi, Yoon-Hyeong] Gachon Univ, Coll Med, Dept Prevent Med, Inchon, South Korea.
   [Choi, Yoon-Hyeong] Gachon Adv Inst Hlth Sci & Technol, Inchon, South Korea.
   [Choi, Yoon-Hyeong] Gachon Univ, Gil Med Ctr, Inchon, South Korea.
C3 Gachon University; Gachon University
RP Choi, YH (corresponding author), 191 Hambakmoeiro, Inchon 406799, South Korea.
EM yoonchoi@gachon.ac.kr
RI Kim, Junghoon/H-4973-2019
OI Kim, Junghoon/0000-0003-4802-010X; Choi, Yoon-Hyeong/0000-0003-3228-8179
FU National Research Foundation of Korea (NRF) - Korea Ministry of
   Education [2013R1A6A3A04059556, 2014R1A1A2059106]
FX This work was supported by the National Research Foundation of Korea
   (NRF) funded by the Korea Ministry of Education (grant number:
   2013R1A6A3A04059556, 2014R1A1A2059106).
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NR 42
TC 26
Z9 27
U1 1
U2 14
PU W B SAUNDERS CO LTD
PI LONDON
PA 32 JAMESTOWN RD, LONDON NW1 7BY, ENGLAND
SN 0033-3506
EI 1476-5616
J9 PUBLIC HEALTH
JI Public Health
PD JUN
PY 2016
VL 135
BP 30
EP 37
DI 10.1016/j.puhe.2016.01.002
PG 8
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA DN9QH
UT WOS:000377414200005
PM 26980481
DA 2025-06-11
ER

PT J
AU Sakuraya, A
   Watanabe, K
   Kawakami, N
   Imamura, K
   Ando, E
   Asai, Y
   Eguchi, H
   Kobayashi, Y
   Nishida, N
   Arima, H
   Shimazu, A
   Tsutsumi, A
AF Sakuraya, Asuka
   Watanabe, Kazuhiro
   Kawakami, Norito
   Imamura, Kotaro
   Ando, Emiko
   Asai, Yumi
   Eguchi, Hisashi
   Kobayashi, Yuka
   Nishida, Norimitsu
   Arima, Hideaki
   Shimazu, Akihito
   Tsutsumi, Akizumi
TI Work-related psychosocial factors and onset of metabolic syndrome among
   workers: a systematic review and meta-analysis protocol
SO BMJ OPEN
LA English
DT Review
ID CORONARY-HEART-DISEASE; NIGHT-SHIFT WORK; JOB STRAIN;
   CARDIOVASCULAR-DISEASE; DIABETES-MELLITUS; BLOOD-PRESSURE; RISK;
   PREVALENCE; STRESS; MORTALITY
AB Introduction Metabolic syndrome is an important public health target because of its high prevalence worldwide. Work-related psychosocial factors have been identified as determinants of metabolic syndrome components. However, there have been no systematic reviews or meta-analyses conducted to evaluate the relationship between work-related psychosocial factors and metabolic syndrome as an aggregated cluster. The aim of this study is to examine this association from published prospective studies.
   Methods and analysis The systematic review and meta-analysis will be conducted using published studies that will be identified from electronic databases (ie, PubMed, EMBASE, PsycINFO, PsycARTICLES and Japan Medical Abstracts Society). Studies that (1) examined the association between work-related psychosocial factors and the onset of metabolic syndrome, (2) had a longitudinal or prospective cohort design, (3) were conducted among workers, (4) provided sufficient data for calculating ORs or relative risk with a 95% CI, (5) were published as original articles written in English or Japanese, and (6) having been published until the end of 2016 will be included. Study selection, data collection, quality assessment and statistical syntheses will be conducted based on discussions among investigators.
   Ethics and dissemination Ethics approval was not required for this study because it was based on published studies. The results and findings of this study will be submitted and published in a scientific peer-reviewed journal. The findings from this study could be useful for assessing metabolic syndrome risk factors in the workplace, and determining approaches for prevention of metabolic syndrome in the future.
C1 [Sakuraya, Asuka; Watanabe, Kazuhiro; Kawakami, Norito; Imamura, Kotaro; Ando, Emiko; Asai, Yumi; Arima, Hideaki; Shimazu, Akihito] Univ Tokyo, Grad Sch Med, Dept Mental Hlth, Tokyo, Japan.
   [Watanabe, Kazuhiro] Japan Soc Promot Sci, Tokyo, Japan.
   [Eguchi, Hisashi; Tsutsumi, Akizumi] Kitasato Univ, Sch Med, Dept Publ Hlth, Tokyo, Kanagawa, Japan.
   [Kobayashi, Yuka] Honda Motor Co Ltd, Tokyo, Japan.
   [Nishida, Norimitsu] Kyoto Ind Hlth Assoc, Kyoto, Japan.
C3 University of Tokyo; Japan Society for the Promotion of Science;
   Kitasato University; Honda Motor Company; Honda Japan
RP Tsutsumi, A (corresponding author), Kitasato Univ, Sch Med, Dept Publ Hlth, Tokyo, Kanagawa, Japan.
EM akizumi@kitasato-u.ac.jp
RI Tsutsumi, Akizumi/AAW-6354-2020
OI Imamura, Kotaro/0000-0003-2584-0666; Sakuraya,
   Asuka/0000-0002-1561-019X; Kobayashi, Yuka/0000-0002-8474-6162; Shimazu,
   Akihito/0000-0002-7172-0043
FU JSPS KAKENHI [26253042]; Grants-in-Aid for Scientific Research
   [15J04085, 26253042] Funding Source: KAKEN
FX This study was supported by JSPS KAKENHI Grant Number 26253042.
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NR 45
TC 10
Z9 10
U1 0
U2 11
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2044-6055
J9 BMJ OPEN
JI BMJ Open
PD JUN
PY 2017
VL 7
IS 6
AR e016716
DI 10.1136/bmjopen-2017-016716
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA FB8LT
UT WOS:000406391200237
PM 28645981
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Er, F
   Çimen, L
   Suveren, C
   Yilmaz, C
   Türközkan, N
AF Er, Fatmanur
   Cimen, Leyla
   Suveren, Ceren
   Yilmaz, Canan
   Turkozkan, Nurten
TI Effects of Aerobic Exercise on Leukocyte-Mediated Liver Destruction in a
   Rat Model of Metabolic Syndrome
SO GAZI MEDICAL JOURNAL
LA English
DT Article
DE Metabolic syndrome; non-alcoholic fatty liver disease; malondialdehyde;
   myeloperoxidase; 3-nitrotyrosine
ID FRUCTOSE; DISEASE; 3-NITROTYROSINE; INFLAMMATION; EXPRESSION; IMPACT
AB Objective: In this study, the levels of malondialdehyde (MDA), myeloperoxidase (MPO), and 3-nitrotyrosine (3-NT), which are known as oxidative/nitrosative stress markers, were investigated in the liver tissues of rats with metabolic syndrome model induced by a high fructose diet, and the possible protective effects of aerobic exercise in fructose-fed rats were determined. Methods: Rats were divided into four groups: control, fructose, exercise, and fructose plus exercise. Metabolic syndrome was induced in rats using 20% (w/v) fructose solution in tap water, and exercise was administered every day at the same hour for an experimental period of 8 weeks in total, 30 min a day, five days a week. After eight weeks, systolic blood pressure (SBP), serum lipid, glucose, insulin, MDA MPO, and 3-NT levels were quantified. Results: The metabolic syndrome model was successfully demonstrated by fructose administration. Compared with the C group, F caused a significant increase in SBP, serum insulin, and triglyceride levels and liver MDA, MPO, and 3-NT levels. Exercise counteracted and healed the changes in SBP, serum insulin, triglyceride, and liver MDA, MPO, and 3-NT levels in fructose-fed rats (p<0.05). Conclusion: These results indicate that high fructose consumption causes metabolic syndrome in rats, and aerobic exercise has beneficial effects on the components of metabolic syndrome. Exercise not only reduces the known risk factors of the disease, but also protects the liver while preventing oxidative and nitrosative damage caused by the MPO-H(2)O(2 )system in the liver, which increases with the effect of fructose and is necessary for the formation of non-alcoholic fatty liver disease.
C1 [Er, Fatmanur] Ataturk Univ, Dept Act & Training, Fac Sports Sci, Erzurum, Turkiye.
   [Cimen, Leyla] Gaziantep Islam Sci & Technol Univ, Fac Med, Dept Med Biochem, Gaziantep, Turkiye.
   [Suveren, Ceren] Gazi Univ, Dept Training Sci, Fac Sports Sci, Ankara, Turkiye.
   [Yilmaz, Canan] Gazi Univ, Fac Med, Dept Biochem, Ankara, Turkiye.
C3 Ataturk University; Gaziantep Islam Science & Technology University;
   Gazi University; Gazi University
RP Er, F (corresponding author), Ataturk Univ, Dept Act & Training, Fac Sports Sci, Erzurum, Turkiye.
EM fatmanur.er@atauni.edu.tr
RI Yılmaz, Canan/AAT-7788-2020; er, fatmanur/HSH-0312-2023; Suveren
   Erdoğan, Ceren/AHB-2645-2022
OI YILMAZ, CANAN/0000-0002-6799-6522
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NR 45
TC 0
Z9 0
U1 0
U2 0
PU GALENOS PUBL HOUSE
PI ISTANBUL
PA Kacamak Sokak 21/1, ISTANBUL, Findikzade, TURKIYE
SN 2147-2092
J9 GAZI MED J
JI Gazi Med. J.
PY 2024
VL 35
IS 4
BP 401
EP 406
DI 10.12996/gmj.2024.4178
PG 6
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA J4W0L
UT WOS:001337072400010
OA gold
DA 2025-06-11
ER

PT J
AU Gehart, H
   Kumpf, S
   Ittner, A
   Ricci, R
AF Gehart, Helmuth
   Kumpf, Susann
   Ittner, Arne
   Ricci, Romeo
TI MAPK signalling in cellular metabolism: stress or wellness?
SO EMBO REPORTS
LA English
DT Review
DE diabetes; insulin signalling; MAPK; metabolism; obesity
ID ACTIVATED PROTEIN-KINASE; N-TERMINAL KINASE; ENDOPLASMIC-RETICULUM
   STRESS; GLYCOGEN-SYNTHASE KINASE-3; GLUCOCORTICOID-RECEPTOR;
   INSULIN-RESISTANCE; IN-VIVO; ADIPOCYTE DIFFERENTIATION; MEDIATED
   PHOSPHORYLATION; GLUCOSE-HOMEOSTASIS
AB Mitogen-activated protein kinase (MAPK) signalling occurs in response to almost any change in the extracellular or intra-cellular milieu that affects the metabolism of the cell, organ or the entire organism. MAPK-dependent signal transduction is required for physiological metabolic adaptation, but inappropriate MAPK signalling contributes to the development of several interdependent pathological traits, collectively known as metabolic syndrome. Metabolic syndrome leads to life-threatening clinical consequences, such as type 2 diabetes. This Review provides an overview of the MAPK-signalling mechanisms that underly basic cellular metabolism, discussing their link to disease.
C1 [Ricci, Romeo] ETH, Inst Cell Biol, Dept Biol, CH-8093 Zurich, Switzerland.
   [Gehart, Helmuth; Ittner, Arne; Ricci, Romeo] CNRS INSERM ULP, IGMBC, F-67404 Illkirch Graffenstaden, France.
   [Ricci, Romeo] Hop Univ Strasbourg, Serv Biochim & Biol Mol, Strasbourg, France.
C3 Swiss Federal Institutes of Technology Domain; ETH Zurich; Institut
   National de la Sante et de la Recherche Medicale (Inserm); Universites
   de Strasbourg Etablissements Associes; Universite de Strasbourg; CHU
   Strasbourg; Universites de Strasbourg Etablissements Associes;
   Universite de Strasbourg
RP Ricci, R (corresponding author), ETH, Inst Cell Biol, Dept Biol, Honggerberg Campus,Schafmattstr 18-HPM F38-1, CH-8093 Zurich, Switzerland.
EM romeo.ricci@cell.biol.ethz.ch
RI Ittner, Arne/ABD-3072-2021; Ricci, Romeo/K-3009-2013
OI Ittner, Arne/0000-0001-5244-6897; Ricci, Romeo/0000-0002-9766-4369
FU European Foundation for the Study of Diabetes (EFSD); Swiss National
   Foundation (SNF) [PP00A-114856]; ETH Independent Investigators' Research
   Award (ETHIIRA); Swiss Society for Endocrinology and Diabetology (SSED);
   EMBO
FX We thank Izabela Sumara for careful reading. H. G. is supported by the
   European Foundation for the Study of Diabetes (EFSD) and the Swiss
   National Foundation (SNF; PP00A-114856). S. K. is funded by the SNF and
   an ETH Independent Investigators' Research Award (ETHIIRA). A. I. is
   funded by the SNF and by the Swiss Society for Endocrinology and
   Diabetology (SSED) Young Investigator award grant. R. R. is supported by
   the SNF and by the EMBO Young Investigator Programme.
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NR 52
TC 236
Z9 269
U1 5
U2 42
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1469-221X
EI 1469-3178
J9 EMBO REP
JI EMBO Rep.
PD NOV
PY 2010
VL 11
IS 11
BP 834
EP 840
DI 10.1038/embor.2010.160
PG 7
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA 671LP
UT WOS:000283507900008
PM 20930846
OA Green Published
DA 2025-06-11
ER

PT J
AU Vahabzadeh, M
   Amiri, N
   Karimi, G
AF Vahabzadeh, Maryam
   Amiri, Nafise
   Karimi, Gholamreza
TI Effects of silymarin on metabolic syndrome: a review
SO JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
LA English
DT Review
DE silymarin; milk thistle; diabetes; hypertension; dyslipidemia; metabolic
   syndrome
ID FATTY LIVER-DISEASE; PANCREATIC BETA-CELLS; INSULIN-RESISTANCE;
   NONALCOHOLIC STEATOHEPATITIS; FIXED COMBINATION; BERBERIS-ARISTATA;
   OXIDATIVE STRESS; LIPID-METABOLISM; VITAMIN-E; SILIBININ
AB Metabolic syndrome is one of the rising global health problems and medical challenges due to several clinical complications it may cause, for example increasing the risk of myocardial infarction and hypertension. However, great attention has been directed toward determining the worthiness of herbal medicines. There are emerging studies on preventive and therapeutic effects of silymarin on different components of metabolic syndrome. Extracted from the dried seeds of milk thistle plant (Silybum marianum L.), silymarin has been used in the treatment of different diseases for many years. Several protective effects have been identified for this herb such as decreasing insulin resistance, regulating blood pressure and lipid profile, as well as antioxidant and cytoprotective effects. This review aims to discuss available human and experimental researches into the promising effects of silymarin on different elements of metabolic syndrome. All related human and experimental papers published from 2012 to date were included in this review. Reviewing different human and experimental studies into the effects of silymarin on metabolic syndrome, we deduced that silymarin possesses promising effects on different components of this syndrome. Although the complete mechanism of action and target organs for silymarin require further verification and investigation, high-risk individuals may benefit from supplementation with this herbal medicine. (c) 2018 Society of Chemical Industry
C1 [Karimi, Gholamreza] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Pharmaceut Res Ctr, Mashhad, Iran.
   [Vahabzadeh, Maryam] Mashhad Univ Med Sci, Fac Med, Med Toxicol Res Ctr, Mashhad, Iran.
   [Amiri, Nafise] Mashhad Univ Med Sci, Sch Pharm, Mashhad, Iran.
   [Karimi, Gholamreza] Mashhad Univ Med Sci, Sch Pharm, Dept Pharmacodynam & Toxicol, Mashhad, Iran.
C3 Mashhad University of Medical Sciences; Mashhad University of Medical
   Sciences; Mashhad University of Medical Sciences; Mashhad University of
   Medical Sciences
RP Karimi, G (corresponding author), Mashhad Univ Med Sci, Pharmaceut Technol Inst, Pharmaceut Res Ctr, Mashhad, Iran.
EM karimig@mums.ac.ir
RI amiri, nafise/AAI-4085-2021; Karimi, Gholamreza/AAD-6369-2019;
   Vahabzadeh, Maryam/I-1998-2019
OI Vahabzadeh, Maryam/0000-0002-6234-1834
FU Vice Chancellor of Research, Mashhad University of Medical Sciences
FX The authors are thankful to the Vice Chancellor of Research, Mashhad
   University of Medical Sciences for financial support.
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NR 49
TC 36
Z9 40
U1 0
U2 36
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-5142
EI 1097-0010
J9 J SCI FOOD AGR
JI J. Sci. Food Agric.
PD OCT
PY 2018
VL 98
IS 13
BP 4816
EP 4823
DI 10.1002/jsfa.9115
PG 8
WC Agriculture, Multidisciplinary; Chemistry, Applied; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture; Chemistry; Food Science & Technology
GA GS0XC
UT WOS:000443232200003
PM 29736939
DA 2025-06-11
ER

PT J
AU McIntyre, RS
   Soczynska, JK
   Liauw, SS
   Woldeyohannes, HO
   Brietzke, E
   Nathanson, J
   Alsuwaidan, M
   Muzina, DJ
   Taylor, VH
   Cha, DS
   Kennedy, SH
AF McIntyre, Roger S.
   Soczynska, Joanna K.
   Liauw, Samantha S.
   Woldeyohannes, Hanna O.
   Brietzke, Elisa
   Nathanson, Jay
   Alsuwaidan, Mohammed
   Muzina, David J.
   Taylor, Valerie H.
   Cha, Danielle S.
   Kennedy, Sidney H.
TI THE ASSOCIATION BETWEEN CHILDHOOD ADVERSITY AND COMPONENTS OF METABOLIC
   SYNDROME IN ADULTS WITH MOOD DISORDERS: RESULTS FROM THE INTERNATIONAL
   MOOD DISORDERS COLLABORATIVE PROJECT
SO INTERNATIONAL JOURNAL OF PSYCHIATRY IN MEDICINE
LA English
DT Article
DE childhood adversity; abuse; neglect; major depressive disorder; bipolar
   disorder; metabolic syndrome
ID BIPOLAR-DISORDER; ABUSE; PATHOPHYSIOLOGY; OBESITY; STRESS; WOMEN
AB Objective: We sought to determine whether a reported history of childhood adversity is associated with components of the National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATP-III)-defined metabolic syndrome in adults with mood disorders. Method: This was a cross-sectional analysis of adult outpatients (N = 373; n = 230 female, n = 143 male; mean age [SD] = 42.86 [14.43]) from the International Mood Disorders Collaborative Project (University of Toronto and Cleveland Clinic) with DSM-IV-defined major depressive disorder and bipolar I/II disorder. Childhood adversity was measured with the Klein Trauma & Abuse-Neglect self-report scale. The groups with and without childhood adversity were compared to determine possible differences in the rates of metabolic syndrome and its components. Logistic and linear regressions adjusted for age, sex, education, employment status, and smoking were used to evaluate the association between childhood adversity and components of metabolic syndrome. Results: For the full sample, 83 subjects (22.25%) met criteria for metabolic syndrome. Individuals reporting a history of any childhood adversity had higher systolic and diastolic blood pressure (systolic: p = 0.040; diastolic: p = 0.038). Among subjects with a history of sexual abuse, a significant proportion met criteria for obesity (45.28% vs. 32.88%; p = 0.010); a trend toward overweight was found for subjects with a history of physical abuse (76.32% vs. 63.33%; p = 0.074), although this relationship did not remain significant after adjusting for potential confounders. There was no statistically significant difference in the overall rate of dyslipidemia and/or metabolic syndrome between subjects with and without childhood adversity. Conclusion: The results herein provide preliminary evidence suggesting that childhood adversity is associated with metabolic syndrome components in individuals with mood disorders. Int'l. J. Psychiatry in Medicine 2012;43:165-177)
C1 [McIntyre, Roger S.] Univ Toronto, Head Mood Disorders Psychopharmacol Unit, Univ Hlth Network, Toronto, ON M5T 2S8, Canada.
   [Brietzke, Elisa] Univ Sao Paulo, BR-05508 Sao Paulo, Brazil.
   [Taylor, Valerie H.] McMaster Univ, Hamilton, ON L8S 4L8, Canada.
C3 University of Toronto; University Health Network Toronto; Universidade
   de Sao Paulo; McMaster University
RP McIntyre, RS (corresponding author), Univ Toronto, Head Mood Disorders Psychopharmacol Unit, Univ Hlth Network, 399 Bathurst St,MP9-325, Toronto, ON M5T 2S8, Canada.
EM roger.mcintyre@uhn.ca
RI Taylor, Valerie/H-6242-2015; McIntyre, Roger/AAU-1000-2020; Brietzke,
   Elisa/G-9559-2012; Kennedy, Sidney/AGR-7227-2022; kennedy,
   sidney/Q-1926-2016
OI Soczynska, Joanna/0000-0003-0003-7164; Alsuwaidan,
   Mohammad/0000-0003-1344-2935; Taylor, Valerie/0000-0002-8948-638X;
   kennedy, sidney/0000-0001-5339-7185
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NR 16
TC 59
Z9 63
U1 0
U2 7
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0091-2174
EI 1541-3527
J9 INT J PSYCHIAT MED
JI Int. J. Psychiatr. Med.
PY 2012
VL 43
IS 2
BP 165
EP 177
DI 10.2190/PM.43.2.e
PG 13
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 964WP
UT WOS:000305727700005
PM 22849038
DA 2025-06-11
ER

PT J
AU Fitch, KV
   Anderson, EJ
   Hubbard, JL
   Carpenter, SJ
   Waddell, WR
   Caliendo, AM
   Grinspoon, SK
AF Fitch, Kathleen V.
   Anderson, Ellen J.
   Hubbard, Jane L.
   Carpenter, Sara J.
   Waddell, William R.
   Caliendo, Angela M.
   Grinspoon, Steven K.
TI Effects of a lifestyle modification program in HIV-infected patients
   with the metabolic syndrome
SO AIDS
LA English
DT Article
DE blood pressure; cardiovascular risk; HIV; lifestyle modification;
   metabolic syndrome
ID HUMAN-IMMUNODEFICIENCY-VIRUS; CORONARY-HEART-DISEASE; ANTIRETROVIRAL
   THERAPY; RISK-FACTORS; ABNORMALITIES; LIPODYSTROPHY; INTERVENTION;
   PREVALENCE; PREVENTION; DIET
AB Objectives: A large percentage of HIV-infected patients receiving HAART develop the metabolic syndrome. In this study, we sought to determine whether lifestyle modification improves metabolic syndrome criteria, including waist circumference, blood pressure, fasting blood sugar, triglycerides, and HDL-cholesterol among HIV-infected patients with the metabolic syndrome.
   Design: We conducted a randomized, 6-month study in HIV-infected patients with metabolic syndrome as defined by the National Cholesterol Education Program. Subjects were randomly assigned to an intensive lifestyle modification program, which included weekly one-on-one counseling sessions with a registered dietician, or observation (control group). Methods: Metabolic syndrome criteria and cardiovascular parameters, including blood pressure, body composition, submaximal stress testing, lipids and other biochemical parameters were determined.
   Results: Thirty-four patients were randomly assigned and 28 subjects completed the study. Compared with the control group, subjects randomly assigned to the lifestyle modification program demonstrated significant decreases in waist circumference (-2.6 +/- 1.1 versus 1.2 +/- 1.0 cm, P = 0.022), systolic blood pressure (-13 +/- 4 versus 4 +/- 4 mmHg, P = 0.008), hemaglobin A1C (-0.1 +/- 0.1 versus 0.2 +/- 0.1 %, P = 0.017), lipodystrophy score (-1.2 +/- 0.3 versus 0.9 +/- 0.6, P = 0.006) and increased activity (17.7 +/- 14.3 versus -33.1 +/- 12.7 metabolic equivalents, P=0.014) as measured by the Modifiable Activity Questionnaire, but lipid levels did not improve.
   Conclusion: These data demonstrate that intensive lifestyle modification significantly improved important cardiovascular risk indices in HIV-infected patients with the metabolic syndrome. Lifestyle modification may be a useful strategy to decrease cardiovascular risk in this population. (c) 2006 Lippincott Williams & Wilkins.
C1 Massachusetts Gen Hosp, Program Nutrit Metab, Boston, MA 02114 USA.
   Massachusetts Gen Hosp, Gen Clin Res Ctr, Boston, MA 02114 USA.
   Massachusetts Gen Hosp, Phys Therapy Dept, Boston, MA 02114 USA.
   Emory Univ, Sch Med, Atlanta, GA 30322 USA.
C3 Harvard University; Harvard University Medical Affiliates; Massachusetts
   General Hospital; Harvard University; Harvard University Medical
   Affiliates; Massachusetts General Hospital; Harvard University; Harvard
   University Medical Affiliates; Massachusetts General Hospital; Emory
   University
RP Grinspoon, SK (corresponding author), Massachusetts Gen Hosp, Program Nutrit Metab, Longfellow 207,55 Fruit St, Boston, MA 02114 USA.
EM sgrinspoon@partners.org
FU NCRR NIH HHS [M01-RR-01066] Funding Source: Medline; NIDDK NIH HHS [P30
   DK040561, R01 DK-49302] Funding Source: Medline
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NR 33
TC 85
Z9 97
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0269-9370
EI 1473-5571
J9 AIDS
JI Aids
PD SEP 11
PY 2006
VL 20
IS 14
BP 1843
EP 1850
DI 10.1097/01.aids.0000244203.95758.db
PG 8
WC Immunology; Infectious Diseases; Virology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Infectious Diseases; Virology
GA 092BK
UT WOS:000241071800007
PM 16954725
OA Bronze
DA 2025-06-11
ER

PT J
AU Alev-Tuzuner, B
   Genc-Kahraman, N
   Ipekci, H
   Ustundag, UV
   Tunali-Akbay, T
   Emekli-Alturfan, E
   Sener, G
   Yarat, A
AF Alev-Tuzuner, Burcin
   Genc-Kahraman, Nevin
   Ipekci, Hazal
   Ustundag, Unsal Veli
   Tunali-Akbay, Tugba
   Emekli-Alturfan, Ebru
   Sener, Goksel
   Yarat, Aysen
TI Brain in metabolic syndrome model: The effect of exercises and caloric
   restriction
SO JOURNAL OF RESEARCH IN PHARMACY
LA English
DT Article
DE Metabolic syndrome; Brain; Antioxidant; Oxidative stress; Exercise;
   Caloric restriction
ID OBESITY
AB Caloric restriction (CR) and exercise (EX) have impacts on improving metabolic risk factors. This study aimed to investigate the changes in the brain after EX and/or CR in metabolic syndrome (MeS) induced by a high fructose diet in rats. Sprague-Dawley male rats were divided into five groups. Drinking water including 10% fructose solution was given to rats for 12 weeks to develop a MeS rat model. Animals with MeS were submitted to EX and/or CR for 6 weeks. Blood glucose, and brain tissue damage and antioxidant parameters were measured. Brain lipid peroxidation, sialic acid, mucin, fucose levels increased in the MeS group compared to the control (C) group. These parameters reduced significantly in the metabolic syndrome with caloric restriction (MeS+CR) group, and more significantly in the metabolic syndrome with exercise and caloric restriction group (MeS+EXCR), compared to the MeS group. Glutathione levels, superoxide dismutase and catalase activities decreased in the MeS group compared to the C group, increased both in the MeS+CR group, and MeS+EXCR group compared to the MeS group. High fructose diet consumption can lead to brain tissue damage and decreased antioxidant levels were found to be improved best in the MeS+EXCR group.
C1 [Alev-Tuzuner, Burcin] Istanbul Gelisim Univ, Fac Dent, Dept Basic Med Sci, Istanbul, Turkey.
   [Genc-Kahraman, Nevin] Bursa Publ Hlth Lab, Med Biochem, Bursa, Turkey.
   [Ipekci, Hazal; Ustundag, Unsal Veli; Tunali-Akbay, Tugba; Emekli-Alturfan, Ebru; Yarat, Aysen] Marmara Univ, Fac Dent, Dept Basic Med Sci, Istanbul, Turkey.
   [Sener, Goksel] Fenerbahce Univ, Vocat Sch Hlth Serv, Istanbul, Turkey.
C3 Istanbul Gelisim University; Marmara University; Fenerbahce University
RP Alev-Tuzuner, B (corresponding author), Istanbul Gelisim Univ, Fac Dent, Dept Basic Med Sci, Istanbul, Turkey.
EM btuzuner@gelisim.edu.tr
RI Emekli-Alturfan, Ebru/X-2758-2019; Tunali Akbay, Tugba/AAS-4127-2020;
   Alev-Tuzuner, Burcin/A-4386-2016
OI Alev-Tuzuner, Burcin/0000-0001-5122-4977; Sener,
   Goksel/0000-0001-7444-6193
FU Marmara University Scientific Research Projects Commission
   [SAG-C-YLP-041213-0449]
FX This work was supported by the by the Marmara University Scientific
   Research Projects Commission (Project No: SAG-C-YLP-041213-0449).
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NR 60
TC 0
Z9 0
U1 0
U2 1
PU MARMARA UNIV
PI ISTANBUL
PA GOZTEPE CAMPUS, KADIKOY, ISTANBUL, 34722, TURKEY
SN 2630-6344
J9 J RES PHARM
JI J. Res. Pharm.
PY 2022
VL 26
IS 5
BP 1352
EP 1362
DI 10.29228/jrp.227
PG 11
WC Pharmacology & Pharmacy
WE Emerging Sources Citation Index (ESCI)
SC Pharmacology & Pharmacy
GA 8U3AM
UT WOS:000929825400025
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Chira, A
   Braicu, C
   Budisan, L
   Chira, RI
   Berindan-Neagoe, I
   Dumitrascu, DL
AF Chira, Alexandra
   Braicu, Cornelia
   Budisan, Liviuta
   Ioan Chira, Romeo
   Berindan-Neagoe, Ioana
   Lucian Dumitrascu, Dan
TI Monocyte chemotactic protein-1 and nitrotyrosine in irritable bowel
   syndrome
SO EXPERIMENTAL AND THERAPEUTIC MEDICINE
LA English
DT Article
DE biomarkers; irritable bowel syndrome; MCP-1; nitrotyrosine; oxidative
   stress
ID CHEMOATTRACTANT PROTEIN-1; SYMPTOMS; MCP-1; EXPRESSION; BIOMARKERS;
   CHEMOKINE; PATHWAYS; OBESITY
AB Irritable bowel syndrome (IBS) is one the most frequent and common functional gastrointestinal disorders that has a multifactorial etiopathogenesis. Multiple biomarkers have been tested in search for a reliable and specific biomarker, but there is not yet a specific biomarker for IBS. The aim of this study was to evaluate two biomarkers of different putative pathways of the pathogenesis of IBS: the monocyte chemotactic protein-1 (MCP-1) and nitrotyrosine, in order to establish their role as potential biomarkers. We enrolled 42 consecutive IBS patients diagnosed by Rome III criteria and 35 consecutive healthy controls. Serum concentrations for the two biomarkers (MCP-1 and nitrotyrosine) were determined using commercial ELISA kits. Serum levels of MCP-1 were not statistically significantly higher in IBS patients than in controls (204 +/- 130 vs. 174 +/- 73 pg/ml; P=0.311). Nitrotyrosine levels were statistically significantly lower in IBS patients than in controls (30 +/- 12 vs. 353 +/- 14 nM; P=0.050). MCP-1 levels were higher in IBS patients with metabolic syndrome versus IBS patients without metabolic syndrome (239 +/- 153 vs. 168 +/- 120 pg/ml; P=0.948) and in controls with metabolic syndrome (174 +/- 56 pg/ml). MCP-1 serum levels were statistically significantly higher in IBS patients with metabolic syndrome than in controls (239 +/- 153 vs. 157 +/- 89 pg/ml; P=0.037), suggesting multiple factors being involved, particularly the diet and its relation with the metabolic syndrome, and it suggests that MCP-1 could be a marker of subclinical atherosclerosis. Low-grade inflammation might be related to oxidative stress, which plays an underestimated role in the pathogenesis of IBS.
C1 [Chira, Alexandra; Lucian Dumitrascu, Dan] Iuliu Hatieganu Univ Med & Pharm, Dept Internal Med, Second Med Clin, Cluj Napoca 400006, Romania.
   [Braicu, Cornelia; Budisan, Liviuta; Berindan-Neagoe, Ioana] Iuliu Hatieganu Univ Med & Pharm, Res Ctr Funct Genom Biomed & Translat Med, Cluj Napoca 400337, Romania.
   [Ioan Chira, Romeo] Iuliu Hatieganu Univ Med & Pharm, First Med Clin, Div Gastroenterol, Dept Internal Med, 3-5 Clinicilor Str, Cluj Napoca 400006, Romania.
   [Berindan-Neagoe, Ioana] Univ Med & Pharm Iuliu Hatieganu, MEDFUTURE Res Ctr Adv Med, Cluj Napoca 400337, Romania.
   [Berindan-Neagoe, Ioana] Oncol Inst Prof Dr Ion Chiricuta, Dept Funct Genom & Expt Pathol, Cluj Napoca 400015, Romania.
C3 Iuliu Hatieganu University of Medicine & Pharmacy; Iuliu Hatieganu
   University of Medicine & Pharmacy; Iuliu Hatieganu University of
   Medicine & Pharmacy; Iuliu Hatieganu University of Medicine & Pharmacy;
   Oncology Institute Prof. Dr. Ion Chiricuta
RP Chira, RI (corresponding author), Iuliu Hatieganu Univ Med & Pharm, First Med Clin, Div Gastroenterol, Dept Internal Med, 3-5 Clinicilor Str, Cluj Napoca 400006, Romania.
EM romeochira@yahoo.com
RI Chira, Romeo/P-7690-2014; Dumitrascu, Dan/C-4618-2011; Berindan-Neagoe,
   Ioana/AAH-9854-2019
FU European Social Fund Human Resources Development Operational Programme
   2007-2013 [POSDRU/159/1.5/S/138776 TRANSCENT]
FX The European Social Fund Human Resources Development Operational
   Programme 2007-2013, funded this study, project no.
   POSDRU/159/1.5/S/138776 TRANSCENT. The funders had no role in study
   design, data collection and analysis, decision to publish, or
   preparation of the manuscript.
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NR 40
TC 2
Z9 2
U1 1
U2 3
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1792-0981
EI 1792-1015
J9 EXP THER MED
JI Exp. Ther. Med.
PD JUL
PY 2020
VL 20
IS 1
BP 24
EP 30
DI 10.3892/etm.2020.8665
PG 7
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA MM0YU
UT WOS:000549886400004
PM 32508988
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Felipe, A
   Guadalupe, E
   Druso, P
   Carlos, M
   Pablo, S
   Oscar, C
   Luis, V
   Diego, M
   Jaime, R
   Inés, U
   Federico, L
AF Felipe, Avila
   Guadalupe, Echeverria
   Druso, Perez
   Carlos, Martinez
   Pablo, Strobel
   Oscar, Castillo
   Luis, Villaroel
   Diego, Mezzano
   Jaime, Rozowski
   Ines, Urquiaga
   Federico, Leighton
TI Serum Ferritin Is Associated with Metabolic Syndrome and Red Meat
   Consumption
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Article
ID IRON OVERLOAD; INSULIN-RESISTANCE; MEDITERRANEAN DIET; RISK;
   HYPERFERRITINEMIA; INFLAMMATION; TRANSFERRIN; PREVALENCE; ABSORPTION;
   LIVER
AB Background and Aims. Hyperferritinemia has been related with a wide spectrum of pathologies, including diabetes, cardiovascular disease, neurodegenerative disorders, and metabolic syndrome. The aim of this study was to investigate the association between hyperferritinemia and iron consumption. Methods and Results. Serum ferritin concentration was evaluated in 66 presumed healthy men, along with other clinical and biochemical markers of chronic diseases. A three-day food questionnaire was applied for nutrition information. Hyperferritinemia was a condition found in 13.4% of the volunteers analyzed. Significant correlations were found between serum ferritin concentration and metabolic syndrome parameters (HDL cholesterol, triglycerides, and fasting glucose) as well as an increase of the serum ferritin mean value with the number of risk factors of metabolic syndrome. Also, oxidative stress markers (carbonyl groups, AOPP, and glycated hemoglobin), hepatic damage markers (GGT, SGOT), and parameters related to insulin resistance (HOMA, blood insulin, and blood glucose) correlate significantly with serum ferritin. Volunteers had an excessive iron intake, principally by bread consumption. Analyses of food intake showed that red meat consumption correlates significantly with serum ferritin. Conclusion. Red meat consumption, metabolic syndrome, and chronic disease markers are associated with hyperferritinemia in a population of Chilean men.
C1 [Felipe, Avila] Univ Talca, PIEI ES, Talca 3460000, Chile.
   [Felipe, Avila; Guadalupe, Echeverria; Druso, Perez; Carlos, Martinez; Pablo, Strobel; Ines, Urquiaga; Federico, Leighton] Pontificia Univ Catolica Chile, Ctr Nutr Mol & Enfermedades Cron, Santiago 8331150, Chile.
   [Oscar, Castillo; Jaime, Rozowski] Pontificia Univ Catolica Chile, Fac Med, Dept Nutr Diabet & Metab, Santiago 8330024, Chile.
   [Luis, Villaroel] Pontificia Univ Catolica Chile, Fac Med, Dept Salud Publ, Santiago 8330024, Chile.
   [Diego, Mezzano] Pontificia Univ Catolica Chile, Fac Med, Lab Hemostasia, Santiago 8330024, Chile.
C3 Universidad de Talca; Pontificia Universidad Catolica de Chile;
   Pontificia Universidad Catolica de Chile; Pontificia Universidad
   Catolica de Chile; Pontificia Universidad Catolica de Chile
RP Inés, U (corresponding author), Pontificia Univ Catolica Chile, Ctr Nutr Mol & Enfermedades Cron, Casilla 114-D, Santiago 8331150, Chile.
EM iurquiaga@bio.puc.cl
RI Echeverría, Guadalupe/GWV-3832-2022; Castillo, Oscar/AAA-2368-2022
OI Echeverria, Guadalupe/0000-0002-2915-0171; Castillo,
   Oscar/0000-0002-4411-8655
FU Center for Molecular Nutrition and Chronic Diseases, Pontificia
   Universidad Catolica de Chile; Universidad de Talca [1692]
FX This work was funded by the Center for Molecular Nutrition and Chronic
   Diseases, Pontificia Universidad Catolica de Chile. F. Avila
   acknowledges Universidad de Talca for research Project No 1692.
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NR 30
TC 22
Z9 22
U1 0
U2 21
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PY 2015
VL 2015
AR 769739
DI 10.1155/2015/769739
PG 8
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA CS3UZ
UT WOS:000362001900001
PM 26451235
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Farajbakhsh, A
   Mazloomi, SM
   Mazidi, M
   Rezaie, P
   Akbarzadeh, M
   Ahmad, SP
   Ferns, GA
   Ofori-Asenso, R
   Babajafari, S
AF Farajbakhsh, Ali
   Mazloomi, Seyed Mohammad
   Mazidi, Mohsen
   Rezaie, Peyman
   Akbarzadeh, Marzieh
   Ahmad, Saeedeh Poor
   Ferns, G. A.
   Ofori-Asenso, Richard
   Babajafari, Siavash
TI Sesame oil and vitamin E co-administration may improve cardiometabolic
   risk factors in patients with metabolic syndrome: a randomized clinical
   trial
SO EUROPEAN JOURNAL OF CLINICAL NUTRITION
LA English
DT Article
ID POLYUNSATURATED FATTY-ACID; OXIDATIVE STRESS; LIPID PROFILE;
   BLOOD-PRESSURE; VEGETABLE-OILS; DIETARY-INTAKE; CARBOHYDRATE;
   INFLAMMATION; METAANALYSIS; TOCOPHEROLS
AB Objectives Metabolic syndrome (MetS) represents a clustering of metabolic abnormalities that are associated with an increased risk of type 2 diabetes and cardiovascular disease. We aimed to evaluate the effects of sesame oil enriched with vitamin E (vit E), sesame oil alone and sunflower oil on lipid profile, fasting blood glucose (FBG), malondialdehyde (MDA), high-sensitivity C-reactive protein (Hs-CRP), homeostatic model assessment (HOMA-IR), and blood pressure (BP) in patients with MetS.
   Subjects Overall, 75 individuals with MetS (aged 30-70 years) participated in this randomized, single-blind controlled trial. Patients were randomly allocated to: (1) Group A (n = 25) : sesame oil (30 ml/day) enriched with vit E (400 mg/day), (2) Group B (n = 25): sesame oil (30 ml/day), (3) Group C (n = 25): sunflower oil (30 ml/day). Anthropometric data, dietary intake, blood pressure, and biochemical markers, including fasting serum lipids, FBG, serum insulin, MDA, and hs-CRP were measured at baseline and at week 8.
   Results In individuals in the sesame oil enriched with vit E group (Group A), there were significant reductions in serum total cholesterol (TC), triglycerides (TG), FBG, HOMA-IR, MDA, hs-CRP, high-density lipoprotein (HDL-C) systolic and diastolic BP (for all the comparison p < 0.02). Similarly, in Group B (taking sesame oil alone), TC, TG, FBG, HOMA-IR, MDA, systolic and diastolic BP were significantly improved (for all the comparison p < 0.025), while there were no significant changes in serum HDL (baseline = 35.9 +/- 7.2 mg/dL vs. 36.4 +/- 6.2 mg/dL, p = 0.432) and hs-CRP (baseline = 4.38 +/- 1.34 mg/dL vs. week 8 = 3.96 +/- 1.7 mg/dL, p = 0.057) in second group. No significant changes in any of the studied clinical and anthropometric data were found in Group C (on sunflower oil).
   Conclusion Sesame oil (+/- vit E) was shown to beneficially affect several cardiometabolic indices (including lipids, FBG, BP, HOMA-IR, and MDA) in patients with MetS.
C1 [Farajbakhsh, Ali; Akbarzadeh, Marzieh; Ahmad, Saeedeh Poor; Babajafari, Siavash] Shiraz Univ Med Sci, Sch Nutr & Food Sci, Dept Clin Nutr, Shiraz, Iran.
   [Mazloomi, Seyed Mohammad] Shiraz Univ Med Sci, Sch & Res Ctr Nutr & Food Sci, Dept Food Hyg & Qual Control, Shiraz, Iran.
   [Mazidi, Mohsen] Chalmers Univ Technol, Dept Biol & Biol Engn, Food & Nutr Sci, SE-41296 Gothenburg, Sweden.
   [Rezaie, Peyman] Univ Adelaide, Adelaide Med Sch, Adelaide, SA, Australia.
   [Ferns, G. A.] Brighton & Sussex Med Sch, Div Med Educ, Brighton, Sussex, England.
   [Ofori-Asenso, Richard] Monash Univ, Dept Epidemiol & Prevent Med, Melbourne, Vic, Australia.
C3 Shiraz University of Medical Science; Shiraz University of Medical
   Science; Chalmers University of Technology; University of Adelaide;
   University of Brighton; University of Sussex; Monash University
RP Babajafari, S (corresponding author), Shiraz Univ Med Sci, Sch Nutr & Food Sci, Dept Clin Nutr, Shiraz, Iran.
EM Jafaris@sums.ac.ir
RI Linn, Shai/N-3079-2019; Esfandabad, Siavash/A-6807-2019; Mazloomi,
   Seyed/K-1625-2013; Rezaie, Peyman/GMX-3967-2022; Akbarzadeh,
   Marzieh/L-4063-2016
OI Mazloomi, Seyed Mohammad/0000-0002-9672-7743; Akbarzadeh,
   Marzieh/0000-0001-7646-2162
FU Shiraz University of Medical Sciences, Shiraz, Iran
FX This study was supported by the Shiraz University of Medical Sciences,
   Shiraz, Iran.
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NR 57
TC 23
Z9 23
U1 1
U2 17
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0954-3007
EI 1476-5640
J9 EUR J CLIN NUTR
JI Eur. J. Clin. Nutr.
PD OCT
PY 2019
VL 73
IS 10
BP 1403
EP 1411
DI 10.1038/s41430-019-0438-5
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA JB4HV
UT WOS:000488517500009
PM 31089253
DA 2025-06-11
ER

PT J
AU Arnaud, J
   de Lorgeril, M
   Akbaraly, T
   Salen, P
   Arnout, J
   Cappuccio, FP
   van Dongen, MCJM
   Donati, MB
   Krogh, V
   Siani, A
   Iacoviello, L
AF Arnaud, J.
   de Lorgeril, M.
   Akbaraly, T.
   Salen, P.
   Arnout, J.
   Cappuccio, F. P.
   van Dongen, M. C. J. M.
   Donati, M. B.
   Krogh, V.
   Siani, A.
   Iacoviello, L.
CA IMMIDIET Project
TI Gender differences in copper, zinc and selenium status in diabetic-free
   metabolic syndrome European population - The IMMIDIET study
SO NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
LA English
DT Article
DE Metabolic syndrome; Copper; Zinc; Selenium; Cardiovascular disease;
   Europe
ID CORONARY-HEART-DISEASE; SERUM SELENIUM; ANTIOXIDANT CONCENTRATIONS;
   OXIDATIVE STRESS; SUPPLEMENTATION; RISK
AB Background and aims: The European 'IMMIDIET' study was designed to evaluate the effect of genetic and dietary habit interactions on cardiovascular disease risk factors in nondiabetic subjects. Copper, zinc and selenium are involved in redox balance and modifications of their homeostasis could be associated with metabolic syndrome. Because few studies have dealt with trace element status in metabolic syndrome with conflicting results, we aimed at investigating the relationships between plasma copper, zinc and selenium concentrations and metabolic syndrome in the IMMIDIET population.
   Methods and results: Male-female couples born and living in Abruzzo, Italy (n = 271); Limburg, Belgium (n = 267), southwest part of London, England (n = 263) and 205 Italian-Belgian mixed couples living in Belgium were enrolled. Data on medical history, hypertension and blood lipid profile, medication use, smoking and alcohol habits, physical activity and socioeconomic status were collected using a standardised questionnaire. Anthropometric, blood pressure, glucose, insulin, lipid profile and copper, zinc and selenium measurements were performed. Participants were classified in two groups according to the presence of metabolic syndrome (Yes/No).
   Comparison between these two groups, performed separately in men and women, indicated no association in men whereas, in women, metabolic syndrome was associated with higher plasma selenium concentrations (odds ratio (OR) = 1.55(1.28-1.89)); this association remained significant after adjustment for age, group, social status, physical activity, energy intake, alcohol consumption, smoking and hormonal status (OR = 1.33 (1.06-1.67)).
   Conclusion: Our results indicate gender differences in the association between plasma selenium concentration and metabolic syndrome without diabetes and may suggest a sub-clinical deleterious effect of high selenium status in women. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Arnaud, J.] CHU Grenoble, Dept Biochim Toxicol & Pharmacol, F-38043 Grenoble 9, France.
   [Arnaud, J.] INSERM, U884, F-38041 Grenoble 9, France.
   [de Lorgeril, M.; Salen, P.] Fac Med, TIMC IMAG CNRS UMR 525, Lab Coeur & Nutr, F-38710 La Tronche, France.
   [Akbaraly, T.] Univ Montpellier I, Hop La Colombiere, INSERM, U888, F-34093 Montpellier 5, France.
   [Akbaraly, T.] UCL, Dept Epidemiol & Publ Hlth, London WC1E 6BT, England.
   [Arnout, J.] Katholieke Univ Leuven, Ctr Mol & Vasc Biol, B-3000 Louvain, Belgium.
   [Cappuccio, F. P.] Univ Warwick, Warwick Med Sch, Clin Sci Res Inst, Coventry CV4 7AL, W Midlands, England.
   [van Dongen, M. C. J. M.] Maastricht Univ, Dept Epidemiol, NL-6200 MD Maastricht, Netherlands.
   [Donati, M. B.; Iacoviello, L.] Catholic Univ, Lab Genet & Environm Epidemiol, Res Labs, John Paul II Ctr High Technol Res & Educ Biomed S, I-86100 Campobasso, Italy.
   [Krogh, V.] Natl Canc Inst, Nutr Epidemiol Unit, I-20133 Milan, Italy.
   [Siani, A.] CNR, Inst Food Sci, Unit Epidemiol & Populat Genet, I-83100 Avellino, Italy.
C3 Communaute Universite Grenoble Alpes; Universite Grenoble Alpes (UGA);
   CHU Grenoble Alpes; Institut National de la Sante et de la Recherche
   Medicale (Inserm); Communaute Universite Grenoble Alpes; Institut
   National Polytechnique de Grenoble; Universite Grenoble Alpes (UGA);
   Centre National de la Recherche Scientifique (CNRS); Institut National
   de la Sante et de la Recherche Medicale (Inserm); Universite de
   Montpellier; CHU de Montpellier; University of London; University
   College London; KU Leuven; University of Warwick; Maastricht University;
   Catholic University of the Sacred Heart; Fondazione IRCCS Istituto
   Nazionale Tumori Milan; Consiglio Nazionale delle Ricerche (CNR);
   Istituto di Scienze dell' Alimentazione (ISA-CNR)
RP Arnaud, J (corresponding author), CHU Grenoble, Dept Biochim Toxicol & Pharmacol, BP 217, F-38043 Grenoble 9, France.
EM JArnaud@chu-grenoble.fr; michel.delorgeril@ujf-grenoble.fr;
   tasnime.akbaraly@inserm.fr; patricia.salen@ujf-grenoble.fr;
   jef.arnout@med.kuleuven.be; f.p.cappuccio@warwick.ac.uk;
   MCJM.vanDongen@EPID.unimaas.nl; mbdonati@rm.unicatt.it;
   krogh@istitutotumori.mi.it; asiani@isa.cnr.it;
   licia.iacoviello@rm.unicatt.it
RI Krogh, Vittorio/AAA-9171-2019; Siani, Alfonso/B-7925-2015; de Lorgeril,
   Michel/M-6546-2014; Cappuccio, Francesco/D-3028-2009; SALEN,
   Patricia/M-6424-2014; Donati, Maria Benedetta/K-6606-2016; Iacoviello,
   Licia/K-4676-2016; Sieri, Sabina/K-4667-2016; Akbaraly,
   Tasnime/H-1389-2018; Krogh, Vittorio/K-2628-2016
OI Donati, Maria Benedetta/0000-0003-1747-5443; Di Castelnuovo, Augusto
   Filippo/0000-0001-9767-7998; Iacoviello, Licia/0000-0003-0514-5885; de
   curtis, amalia/0000-0001-5104-0318; Cappuccio, Francesco
   Paolo/0000-0002-7842-5493; Sieri, Sabina/0000-0001-5201-172X; Akbaraly,
   Tasnime/0000-0002-2150-4190; Miller, Michelle/0000-0002-6696-0923;
   Krogh, Vittorio/0000-0003-0122-8624; Bellegotti,
   Manuela/0009-0007-2744-0179; di Giuseppe, Romina/0000-0002-5214-8897;
   Persichillo, Mariarosaria/0000-0002-9731-0173
FU European Union [QLK1-2000-00100]; BUPA Foundation (UK)
FX The IMMIDIET Project was supported by European Union grant No.
   QLK1-2000-00100. TNA was supported by the BUPA Foundation (UK).
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NR 30
TC 64
Z9 68
U1 0
U2 19
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0939-4753
EI 1590-3729
J9 NUTR METAB CARDIOVAS
JI Nutr. Metab. Carbiovasc. Dis.
PD JUN
PY 2012
VL 22
IS 6
BP 517
EP 524
DI 10.1016/j.numecd.2010.09.005
PG 8
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism; Nutrition
   & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism;
   Nutrition & Dietetics
GA 945AQ
UT WOS:000304245600008
PM 21193294
DA 2025-06-11
ER

PT J
AU Hidalgo-Mora, JJ
   Cortés-Sierra, L
   García-Pérez, MA
   Tarín, JJ
   Cano, A
AF Hidalgo-Mora, Juan Jose
   Cortes-Sierra, Laura
   Garcia-Perez, Miguel-angel
   Tarin, Juan J.
   Cano, Antonio
TI Diet to Reduce the Metabolic Syndrome Associated with Menopause. The
   Logic for Olive Oil
SO NUTRIENTS
LA English
DT Review
DE olive oil; metabolic syndrome; obesity; women; menopause; healthy ageing
ID CARDIOVASCULAR RISK-FACTORS; POLYCYSTIC-OVARY-SYNDROME; HORMONE-BINDING
   GLOBULIN; MEDITERRANEAN DIET; OXIDATIVE STRESS; BLOOD-PRESSURE;
   DENSITY-LIPOPROTEIN; GUT MICROBIOTA; HEALTH; ANTIOXIDANT
AB The rates of metabolic syndrome are increasing in parallel with the increasing prevalence of obesity, primarily due to its concomitant insulin resistance. This is particularly concerning for women, as the years around menopause are accompanied by an increase in visceral obesity, a strong determinant of insulin resistance. A fall in estrogens and increase in the androgen/estrogen ratio is attributed a determining role in this process, which has been confirmed in other physiological models, such as polycystic ovary syndrome. A healthy lifestyle, with special emphasis on nutrition, has been recommended as a first-line strategy in consensuses and guidelines. A consistent body of evidence has accumulated suggesting that the Mediterranean diet, with olive oil as a vital component, has both health benefits and acceptable adherence. Herein, we provide an updated overview of current knowledge on the benefits of olive oil most relevant to menopause-associated metabolic syndrome, including an analysis of the components with the greatest health impact, their effect on basic mechanisms of disease, and the state of the art regarding their action on the main features of metabolic syndrome.
C1 [Hidalgo-Mora, Juan Jose; Cortes-Sierra, Laura; Cano, Antonio] Hosp Clin Univ INCLIVA, Serv Obstet & Gynecol, Ave Blasco Ibanez 17, Valencia 46010, Spain.
   [Garcia-Perez, Miguel-angel] Univ Valencia, Fac Biol Sci, Dept Genet, Burjassot, Spain.
   [Garcia-Perez, Miguel-angel] INCLIVA, Ave Blasco Ibanez 17, Valencia 46010, Spain.
   [Tarin, Juan J.] Univ Valencia, Fac Biol Sci, Dept Cellular Biol Funct Biol & Phys Anthropol, Valencia 46100, Spain.
   [Cano, Antonio] Univ Valencia, Dept Pediat Obstet & Gynecol, Ave Blasco Ibanez 15, Valencia 46010, Spain.
C3 University of Valencia; University of Valencia; University of Valencia
RP Cano, A (corresponding author), Hosp Clin Univ INCLIVA, Serv Obstet & Gynecol, Ave Blasco Ibanez 17, Valencia 46010, Spain.; Cano, A (corresponding author), Univ Valencia, Dept Pediat Obstet & Gynecol, Ave Blasco Ibanez 15, Valencia 46010, Spain.
EM hidalgomorajj@gmail.com; cortes_lausie@gva.es; Miguel.Garcia@uv.es;
   Juan.J.Tarin@uv.es; antonio.cano@uv.es
RI Tarin, Juan/ABF-5681-2020; Garcia Perez, Miguel Angel/S-8090-2018
OI Cano, Antonio/0000-0001-8046-0303; Tarin, Juan J./0000-0002-4436-5162;
   Garcia Perez, Miguel Angel/0000-0002-0626-7502
FU FOCUS [664367]; Consumers, Health, Agriculture and Food Executive Agency
   (CHAFEA) of the European Commission, under the European Union Health
   Programme
FX This research received funding from grant number 664367 FOCUS, from the
   Consumers, Health, Agriculture and Food Executive Agency (CHAFEA) of the
   European Commission, under the European Union Health Programme
   (2014-2020).
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NR 118
TC 7
Z9 7
U1 1
U2 19
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD OCT
PY 2020
VL 12
IS 10
AR 3184
DI 10.3390/nu12103184
PG 16
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA OM7VO
UT WOS:000586227500001
PM 33081027
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Roncal-Jimenez, CA
   Lanaspa, MA
   Rivard, CJ
   Nakagawa, T
   Sanchez-Lozada, LG
   Jalal, D
   Andres-Hernando, A
   Tanabe, K
   Madero, M
   Li, NX
   Cicerchi, C
   Mc Fann, K
   Sautin, YY
   Johnson, RJ
AF Roncal-Jimenez, Carlos A.
   Lanaspa, Miguel A.
   Rivard, Christopher J.
   Nakagawa, Takahiko
   Gabriela Sanchez-Lozada, L.
   Jalal, Diana
   Andres-Hernando, Ana
   Tanabe, Katsuyuki
   Madero, Magdalena
   Li, Nanxing
   Cicerchi, Christina
   Mc Fann, Kim
   Sautin, Yuri Y.
   Johnson, Richard J.
TI Sucrose induces fatty liver and pancreatic inflammation in male breeder
   rats independent of excess energy intake
SO METABOLISM-CLINICAL AND EXPERIMENTAL
LA English
DT Article
ID MUSCLE-CELL PROLIFERATION; URIC-ACID; BLOOD-PRESSURE; DIETARY FRUCTOSE;
   SPRAGUE-DAWLEY; INSULIN-RESISTANCE; METABOLISM; INTESTINE; PROTEIN;
   YOUNG
AB Fructose induces metabolic syndrome in rats; but studies have been criticized for using high concentrations of fructose that are not physiologic, for using only pure fructose, and for not controlling for energy intake. We tested the hypothesis that a 40% sucrose diet (containing 20% fructose) might induce features of metabolic syndrome in male breeder rats independent of excess energy intake. Male Sprague-Dawley breeder rats were pair fed 40% sucrose or isocaloric starch diet for 4 months and evaluated for metabolic syndrome and diabetes. In vitro studies were performed in rat insulinoma cells (RIN-m5F) exposed to uric acid, and markers of inflammation were assessed. Rats fed a 40% sucrose diet developed accelerated features of metabolic syndrome with up-regulation of fructose-dependent transporter Glut5 and fructokinase. Fatty liver and low-grade pancreatic inflammation also occurred. Uric acid was found to stimulate inflammatory mediators and oxidative stress in islet cells in vitro. Sucrose, at concentrations ingested by a subset of Americans, can accelerate metabolic syndrome, fatty liver, and type 2 diabetes mellitus in male breeder rats; and the effects are independent of excess energy intake. (C) 2011 Elsevier Inc. All rights reserved.
C1 [Roncal-Jimenez, Carlos A.] Univ Colorado, Hlth Sci Ctr, Div Renal Dis & Hypertens, Box C281, Aurora, CO 80045 USA.
   [Nakagawa, Takahiko; Johnson, Richard J.] Univ Florida, Div Nephrol Hypertens & Transplantat, Gainesville, FL USA.
   [Gabriela Sanchez-Lozada, L.; Madero, Magdalena] Inst Nacl Cardiol Ignacio Chavez, Mexico City 14080, DF, Mexico.
C3 University of Colorado System; University of Colorado Anschutz Medical
   Campus; State University System of Florida; University of Florida;
   National Institute of Cardiology - Mexico
RP Roncal-Jimenez, CA (corresponding author), Univ Colorado, Hlth Sci Ctr, Div Renal Dis & Hypertens, Box C281, Aurora, CO 80045 USA.
EM carlos.roncal@ucdenver.edu
RI Tanabe, Katsuyuki/J-1341-2019; Sanchez-Lozada, Laura/AAS-2104-2021;
   Lanaspa, Miguel/AAO-4971-2020
OI Andres-Hernando, Ana/0000-0002-0676-0188; Sanchez-Lozada,
   Laura-Gabriela/0000-0003-0348-9617; Jalal, Diana/0000-0002-1975-8650
FU National Institutes of Health [HL-68607]; University of Colorado
FX Supported by National Institutes of Health grant HL-68607 and startup
   funds at the University of Colorado (RJJ).
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NR 59
TC 129
Z9 139
U1 0
U2 12
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0026-0495
EI 1532-8600
J9 METABOLISM
JI Metab.-Clin. Exp.
PD SEP
PY 2011
VL 60
IS 9
BP 1259
EP 1270
DI 10.1016/j.metabol.2011.01.008
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 811FT
UT WOS:000294192000009
PM 21489572
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Farahani, RA
   Yu, SS
   Ferguson, CM
   Zhu, XY
   Tang, H
   Jordan, KL
   Saadiq, IM
   Herrmann, SM
   Chade, AR
   Lerman, A
   Lerman, LO
   Eirin, A
AF Farahani, Rahele A.
   Yu, Shasha
   Ferguson, Christopher M.
   Zhu, Xiang-Yang
   Tang, Hui
   Jordan, Kyra L.
   Saadiq, Ishran M.
   Herrmann, Sandra M.
   Chade, Alejandro R.
   Lerman, Amir
   Lerman, Lilach O.
   Eirin, Alfonso
TI Renal Revascularization Attenuates Myocardial Mitochondrial Damage and
   Improves Diastolic Function in Pigs with Metabolic Syndrome and
   Renovascular Hypertension
SO JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
LA English
DT Article
DE Renovascular hypertension; Cardiac dysfunction; Metabolic syndrome;
   Mitochondria; Revascularization
ID OXIDATIVE STRESS; GLOMERULAR-FILTRATION; HYDROGEN-PEROXIDE; INJURY;
   OUTCOMES; MODEL
AB Percutaneous transluminal renal angioplasty (PTRA) may improve cardiac function in renovascular hypertension (RVH), but its effect on the biological mechanisms implicated in cardiac damage remains unknown. We hypothesized that restoration of kidney function by PTRA ameliorates myocardial mitochondrial damage and preserves cardiac function in pigs with metabolic syndrome (MetS) and RVH. Pigs were studied after 16 weeks of MetS+RVH, MetS+RVH treated 4 weeks earlier with PTRA, and Lean and MetS Sham controls (n=6 each). Cardiac function was assessed by multi-detector CT, whereas cardiac mitochondrial morphology and function, microvascular remodeling, and injury pathways were assessed ex vivo. PTRA attenuated myocardial mitochondrial damage, improved capillary and microvascular maturity, and ameliorated oxidative stress and fibrosis, in association with attenuation of left ventricular remodeling and diastolic dysfunction. Myocardial mitochondrial damage correlated with myocardial injury and renal dysfunction. Preservation of myocardial mitochondria with PTRA can enhance cardiac recovery, underscoring its therapeutic potential in experimental MetS+RVH.
C1 [Farahani, Rahele A.; Yu, Shasha; Ferguson, Christopher M.; Zhu, Xiang-Yang; Tang, Hui; Jordan, Kyra L.; Saadiq, Ishran M.; Herrmann, Sandra M.; Lerman, Lilach O.; Eirin, Alfonso] Mayo Clin, Div Nephrol & Hypertens, Dept Internal Med, 200 First St SW, Rochester, MN 55905 USA.
   [Chade, Alejandro R.] Univ Mississippi, Med Ctr, Dept Physiol & Biophys, Jackson, MS 39216 USA.
   [Lerman, Amir; Lerman, Lilach O.] Mayo Clin, Dept Cardiovasc Dis, Rochester, MN 55905 USA.
C3 Mayo Clinic; University of Mississippi Medical Center; University of
   Mississippi; Mayo Clinic
RP Eirin, A (corresponding author), Mayo Clin, Div Nephrol & Hypertens, Dept Internal Med, 200 First St SW, Rochester, MN 55905 USA.
EM eirinmassat.alfonso@mayo.edu
RI Lerman, Lilach/M-4962-2017; Eirin, Alfonso/N-9873-2013
OI Eirin, Alfonso/0000-0002-3864-9644
FU NIH [DK122137, DK104273, DK120292, HL095638, DK118120, DK102325];
   National Institute of Diabetes and Digestive and Kidney Diseases
   [K08DK118120, R01DK120292] Funding Source: NIH RePORTER
FX This work was supported by the NIH grants: DK122137, DK104273, DK120292,
   HL095638, DK118120, and DK102325.
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NR 48
TC 7
Z9 7
U1 0
U2 2
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1937-5387
EI 1937-5395
J9 J CARDIOVASC TRANSL
JI J. Cardiovasc. Transl. Res.
PD FEB
PY 2022
VL 15
IS 1
BP 15
EP 26
DI 10.1007/s12265-021-10155-3
EA JUL 2021
PG 12
WC Cardiac & Cardiovascular Systems; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Research & Experimental Medicine
GA 0C0LU
UT WOS:000673272500001
PM 34269985
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Pilar, BC
   Gülllich, AAD
   Ströher, DJ
   Zuravski, L
   Mezzomo, J
   Coelho, RP
   Faoro, D
   Piccoli, JDE
   Manfredini, V
AF Pilar, Bruna Cocco
   da Costa Guelllich, Angelica Aparecida
   Stroeher, Deise Jaqueline
   Zuravski, Luisa
   Mezzomo, Juliana
   Coelho, Ritiele Pinto
   Faoro, Debora
   Escobar Piccoli, Jacqueline da Costa
   Manfredini, Vanusa
TI 28-days dietary supplementation with golden flaxseed improves
   biochemical and oxidative parameters in patients with metabolic syndrome
SO JOURNAL OF FUNCTIONAL FOODS
LA English
DT Article
DE Flaxseed; Metabolic syndrome; Anthropometric parameters; Blood pressure;
   Biochemical parameters; Oxidative parameters
ID BLOOD-PRESSURE; DNA-DAMAGE; MICRONUCLEUS FREQUENCY; ANTIOXIDANT
   ACTIVITY; CARDIOVASCULAR RISK; FREE-RADICALS; LIFE-STYLE; STRESS; OIL;
   CONSUMPTION
AB The effects of supplementation with golden flaxseed for 28 days on anthropometric, blood pressure, biochemical and oxidative parameters in patients with metabolic syndrome (MS) were investigated. Twenty patients with MS and 24 healthy volunteers consumed 40 g of golden flaxseed daily for 28 days. Anthropometric and blood pressure measurements and fasting blood samples were taken before and after supplementation. Biochemical assays demonstrated significant reductions in lipid and glucose levels and cardiac, hepatic and kidney markers. Oxidative parameters showed significant reductions (p < 0.05) in oxidative damage to lipids and proteins and a significant improvement (p < 0.05) in enzymatic and nonenzymatic antioxidant defenses. There were no significant differences in anthropometric parameters, blood pressure, urine analysis and DNA damage. Thus, golden flaxseed can be used as an adjunct in the treatment of patients with MS, as it improves biochemical and oxidative stress parameters. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Pilar, Bruna Cocco; da Costa Guelllich, Angelica Aparecida; Stroeher, Deise Jaqueline; Zuravski, Luisa; Manfredini, Vanusa] Fed Univ Pampa, Postgrad Program Biochem, Uruguaiana, RS, Brazil.
   [Escobar Piccoli, Jacqueline da Costa] Fed Univ Pampa, Postgrad Program Pharmaceut Sci, Uruguaiana, RS, Brazil.
   [Mezzomo, Juliana; Coelho, Ritiele Pinto; Faoro, Debora; Escobar Piccoli, Jacqueline da Costa; Manfredini, Vanusa] Fed Univ Pampa, Course Pharm, Uruguaiana, RS, Brazil.
C3 Universidade Federal do Pampa; Universidade Federal do Pampa;
   Universidade Federal do Pampa
RP Manfredini, V (corresponding author), Fed Univ Pampa, Postgrad Program Biochem, Uruguaiana, RS, Brazil.
EM vanusamanfredini@unipampa.edu.br
RI Piccoli, Jacqueline/AFQ-2824-2022; Zuravski, Luisa/O-4160-2018
OI Zuravski, Luisa/0000-0003-4935-665X
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NR 78
TC 14
Z9 14
U1 0
U2 24
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1756-4646
EI 2214-9414
J9 J FUNCT FOODS
JI J. Funct. Food.
PD SEP
PY 2014
VL 10
BP 232
EP 242
DI 10.1016/j.jff.2014.06.020
PG 11
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA AP4GC
UT WOS:000342034200026
DA 2025-06-11
ER

PT J
AU Khoshnaw, DM
   Ghadge, AA
AF Khoshnaw, Dastan M.
   Ghadge, Abhijit A.
TI Yoga as a complementary therapy for metabolic syndrome: A narrative
   review
SO JOURNAL OF INTEGRATIVE MEDICINE-JIM
LA English
DT Review
DE Cardiovascular diseases; Diabetes; Metabolic syndrome; Obesity; Yoga
ID LIFE-STYLE INTERVENTION; QUALITY-OF-LIFE; TYPE-2 DIABETES-MELLITUS;
   DISEASE RISK-FACTORS; OXIDATIVE STRESS; CARDIOVASCULAR-DISEASE; HATHA
   YOGA; ADIPONECTIN; EXERCISE; ADULTS
AB Metabolic syndrome (MS) is associated with a sedentary and stressful lifestyle and affects underactive people disproportionately. Yoga is considered to be a low-impact mind-body stress-relieving exercise, and researchers are increasing their focus on the benefits of yoga for managing metabolic disorders. It is also important for physicians and health care professionals to understand the therapeutic efficacy of yoga intervention, in terms of its type, duration and frequency on various MS risk factors. The present review summarizes the current scientific understanding of the effects of yoga on MS risk factors such as glucose homeostasis markers, lipid profile, adipocytokines and cardiovascular risk factors, and discusses the possible mechanisms of action. MEDLINE, PubMed, Scopus and Cochrane Library were searched from their inception up to December 2019, using the keywords "metabolic syndrome," "diabetes," "cardiovascular diseases," "obesity" and "yoga." The literature summarized in this review have shown mixed effects of yoga on MS risk factors and do not provide robust evidence for its efficacy. More rigorous research and well-designed trials that have a higher standard of methodology and evaluate yoga's long-term impacts on MS are needed. Understanding yoga's biochemical and molecular mechanisms of action on various metabolic pathways is also needed. Please cite this article as: Khoshnaw DM, Ghadge AA. Yoga as a complementary therapy for metabolic syndrome: A narrative review. J Integr Med. 2021; 19(1): 6-12. (c) 2020 Shanghai Changhai Hospital. Published by ELSEVIER B.V. All rights reserved.
C1 [Khoshnaw, Dastan M.] Savitribai Phule Pune Univ, Fergusson Coll, Dept Bot, Pune 411004, Maharashtra, India.
   [Ghadge, Abhijit A.] Bharati Vidyapeeth, Interact Res Sch Hlth Affairs, Diabet Lab, Pune 411043, Maharashtra, India.
C3 Savitribai Phule Pune University; Bharati Vidyapeeth Deemed University
RP Ghadge, AA (corresponding author), Bharati Vidyapeeth, Interact Res Sch Hlth Affairs, Diabet Lab, Pune 411043, Maharashtra, India.
EM abhi01ghadge@gmail.com
RI Khoshnaw, Dastan/ADF-0906-2022
OI Khoshnaw, Dastan Mohammed/0000-0002-1087-5199
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NR 86
TC 21
Z9 21
U1 1
U2 13
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2095-4964
J9 J INTEGR MED-JIM
JI J. Integr. Med.-JIM
PD JAN
PY 2021
VL 19
IS 1
BP 6
EP 12
DI 10.1016/j.joim.2020.09.002
EA JAN 2021
PG 7
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA QA1FH
UT WOS:000613195100002
PM 32952098
DA 2025-06-11
ER

PT J
AU Kagota, S
   Tada, Y
   Nejime, N
   Nakamura, K
   Kunitomo, M
   Shinozuka, K
AF Kagota, Satomi
   Tada, Yukari
   Nejime, Namie
   Nakamura, Kazuki
   Kunitomo, Masaru
   Shinozuka, Kazumasa
TI Telmisartan provides protection against development of impaired
   vasodilation independently of metabolic effects in
   SHRSP.Z-Lepr<SUP>fa</SUP>/IzmDmcr rats with metabolic syndrome
SO CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
LA English
DT Article
DE metabolic syndrome; vasodilation; angitotensin II; AT1 receptor;
   PPAR-gamma; telmisartan; pioglitazone; nitrative stress
ID ACTIVATED RECEPTOR-GAMMA; IMPROVES VASCULAR FUNCTION; RENIN-ANGIOTENSIN
   SYSTEM; SHR/NDMCR-CP RATS; DIABETIC-RATS; ANIMAL-MODEL; ENDOTHELIAL
   DYSFUNCTION; SUPEROXIDE-PRODUCTION; AGONIST PIOGLITAZONE;
   HYPERTENSIVE-RATS
AB Metabolic syndrome is known to facilitate the development of cardiovascular disease. We have demonstrated that mesenteric arteries of SHRSP. Z-Lepr(fa)/IzmDmcr (SHRSP-fatty) rats with metabolic syndrome display an impaired vasorelaxation response mediated by nitric oxide. We examined whether the condition could be alleviated by treatment with telmisartan, an angiotensin II type 1 (AT1) receptor antagonist with PPAR-g-activating properties and compared the results with those from pioglitazone, a PPAR-g agonist. Telmisartan (5 mg.kg(-1.)day(-1)) or pioglitazone (2.5 mg.kg(-1).day(-1)) was orally administered to male SHRSP-fatty rats for 8 weeks. Serum triglyceride and cholesterol levels were determined, and the oral glucose tolerance test was performed to evaluate insulin resistance. Vasodilations in response to acetylcholine and nitroprusside were determined by wire myographs under isometric tension conditions, protein expressions of soluble guanylyl cyclase in mesenteric arteries by Western blotting, and the contents of 3-nitrotyrosine in aortas by high-performance liquid chromatography with electrochemical detection. Telmisartan exerted antihypertensive effects, while pioglitazone ameliorated metabolic abnormalities in SHRSP-fatty rats. Telmisartan increased acetylcholine-and nitroprusside-induced relaxation and soluble guanylyl cyclase protein expression in mesenteric arteries and reduced 3-nitrotyrosine content in aortas. Pioglitazone displayed no such alleviating effects on vascular functions. These findings indicate that telmisartan protects against vasodilation disturbance through anti-oxidative and -nitrative stress independently of metabolic effects in SHRSP-fatty rats with metabolic syndrome.
C1 [Kagota, Satomi; Tada, Yukari; Nejime, Namie; Nakamura, Kazuki; Kunitomo, Masaru; Shinozuka, Kazumasa] Mukogawa Womens Univ, Dept Pharmacol, Sch Pharm & Pharmaceut Sci, Nishinomiya, Hyogo 6638179, Japan.
C3 Mukogawa Women's University
RP Kagota, S (corresponding author), Mukogawa Womens Univ, Dept Pharmacol, Sch Pharm & Pharmaceut Sci, 11-68 Koshien Kyuban Cho, Nishinomiya, Hyogo 6638179, Japan.
EM skagota@mukogawa-u.ac.jp
FU Mukogawa Women's University for studying lifestyle-related diseases;
   Ministry of Education, Science, Sports, and Culture of Japan; Smoking
   Research Foundation, Japan
FX The authors are grateful to Nippon Boehringer Ingelheim Co., Ltd.,
   Hyogo, Japan, and Takeda Pharmaceutical Co., Ltd., Tokyo, Japan, for
   their generous gift of telmisartan and pioglitazone, respectively. We
   thank Ms. M. Kawamoto, Ms. K. Nishida, Ms. M. Hayashida, and Ms. M.
   Miyaguchi for their technical assistance. This research was partly
   supported by the Open Research Center Project of Mukogawa Women's
   University for studying lifestyle-related diseases, a Grant-in-Aid for
   Scientific Research from the Ministry of Education, Science, Sports, and
   Culture of Japan, and a grant from the Smoking Research Foundation,
   Japan.
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NR 45
TC 19
Z9 21
U1 0
U2 5
PU CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS
PI OTTAWA
PA 1200 MONTREAL ROAD, BUILDING M-55, OTTAWA, ON K1A 0R6, CANADA
SN 0008-4212
J9 CAN J PHYSIOL PHARM
JI Can. J. Physiol. Pharmacol.
PD MAY
PY 2011
VL 89
IS 5
BP 355
EP 363
DI 10.1139/Y11-029
PG 9
WC Pharmacology & Pharmacy; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Physiology
GA 775PF
UT WOS:000291472600006
PM 21619437
DA 2025-06-11
ER

PT J
AU Giral, P
   Ratziu, V
   Couvert, P
   Carrié, A
   Kontush, A
   Girerd, X
   Chapman, MJ
AF Giral, Philippe
   Ratziu, Vlad
   Couvert, Philippe
   Carrie, Alain
   Kontush, Anatol
   Girerd, Xavier
   Chapman, M. John
TI Plasma bilirubin and gamma-glutamyltransferase activity are inversely
   related in dyslipidemic patients with metabolic syndrome: Relevance to
   oxidative stress
SO ATHEROSCLEROSIS
LA English
DT Article
DE Metabolic syndrome; Gamma-glutamyltransferase; Bilirubin; Oxidation
ID DENSITY-LIPOPROTEIN; HEART-DISEASE; ASSOCIATION; MORTALITY; RISK;
   ATHEROSCLEROSIS; ANTIOXIDANT; DIAGNOSIS; RESPECT; MARKER
AB Background: Subnormal levels of plasma bilirubin levels are associated with premature coronary artery disease and cardiovascular morbidity. Plasma gamma-glutamyltransferase (GGT) activity is linked to bilirubin level in hepatic disease and elevated GGT is equally associated with hepatic steatosis, a frequent feature of metabolic syndrome (MS). In order to assess the potential relationship between GGT activity and bilirubin levels in subjects exhibiting features of the metabolic syndrome, we determined circulating bilirubin levels and GGT activity in a cohort of dyslipidemic patients.
   Methods and results: This cross-sectional study involved patients (n = 1433) displaying atherogenic dyslipidemia in primary prevention referred to our Prevention Center. Among these patients, 25% presented with MS as defined by recent NCEP ATP III criteria. Circulating levels of transaminases, as well as GGT activity, were elevated in MS patients; by contrast, bilirubin concentrations were significantly lower in such patients as compared to those lacking this syndrome (p < 10-4 for all comparisons). Comparisons of patient groups on the basis of the number of MS criteria which were concomitantly present revealed a progressive decrease in mean bilirubin levels; this reduction paralleled a progressive increase in mean GGT activity as a function of the number of MS components in the overall population (p value for trend < 10-4).
   Conclusion: Elevation in systemic GGT activity, which is characterized by extended generation of ROS, together with potentially deficient bilirubin-mediated antioxidative capacity of plasma, may therefore constitute key components of the systemic oxidative stress typical of metabolic syndrome. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
C1 [Giral, Philippe; Girerd, Xavier] Univ Paris 06, Grp Hosp Pitie Salpetriere, Serv Endocrinol Metab, Unites Prevent Cardiovasc,AP HP, F-75651 Paris 13, France.
   [Ratziu, Vlad] Univ Paris 06, Grp Hosp Pitie Salpetriere, Serv Hepatol, AP HP, F-75651 Paris 13, France.
   [Couvert, Philippe; Carrie, Alain] Univ Paris 06, Grp Hosp Pitie Salpetriere, Serv Biochim, AP HP, F-75651 Paris 13, France.
   [Giral, Philippe; Couvert, Philippe; Carrie, Alain; Kontush, Anatol; Girerd, Xavier; Chapman, M. John] INSERM, Natl Inst Hlth & Med Res, Dyslipoproteinemia & Atherosclerosis Res Unit, UMRS 939, F-75654 Paris 13, France.
C3 Sorbonne Universite; Assistance Publique Hopitaux Paris (APHP); Hopital
   Universitaire Pitie-Salpetriere - APHP; Assistance Publique Hopitaux
   Paris (APHP); Hopital Universitaire Pitie-Salpetriere - APHP; Sorbonne
   Universite; Sorbonne Universite; Assistance Publique Hopitaux Paris
   (APHP); Hopital Universitaire Pitie-Salpetriere - APHP; Institut
   National de la Sante et de la Recherche Medicale (Inserm)
RP Giral, P (corresponding author), Univ Paris 06, Grp Hosp Pitie Salpetriere, Serv Endocrinol Metab, Unites Prevent Cardiovasc,AP HP, 47-83 Blvd Hop, F-75651 Paris 13, France.
EM philippe.giral@psl.aphp.fr
RI Ratziu, Vlad/AFL-9740-2022; Couvert, Philippe/IQW-2669-2023; chapman,
   john/Y-2742-2019; Kontush, Anatol/J-2198-2016
OI Kontush, Anatol/0000-0002-9008-7335; Couvert,
   Philippe/0000-0002-7607-2057; Carrie, Alain/0000-0003-4726-1171
FU Assistance-Publique-Hopitaux de Paris; INSERM
FX This study was supported by Assistance-Publique-Hopitaux de Paris and
   INSERM. M.J.C. gratefully acknowledges the award of a "Contrat
   d'Interface APHP/INSERM".
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NR 29
TC 49
Z9 52
U1 2
U2 9
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0021-9150
EI 1879-1484
J9 ATHEROSCLEROSIS
JI Atherosclerosis
PD JUN
PY 2010
VL 210
IS 2
BP 607
EP 613
DI 10.1016/j.atherosclerosis.2009.12.026
PG 7
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 601CY
UT WOS:000278036800048
PM 20129611
DA 2025-06-11
ER

PT J
AU Kanfi, Y
   Peshti, V
   Gil, R
   Naiman, S
   Nahum, L
   Levin, E
   Kronfeld-Schor, N
   Cohen, HY
AF Kanfi, Yariv
   Peshti, Victoria
   Gil, Reuven
   Naiman, Shoshana
   Nahum, Liat
   Levin, Eran
   Kronfeld-Schor, Noga
   Cohen, Haim Y.
TI SIRT6 protects against pathological damage caused by diet-induced
   obesity
SO AGING CELL
LA English
DT Article
DE diet-induced obesity; metabolic syndrome; SIRT6
ID PANCREATIC BETA-CELLS; CALORIE RESTRICTION; METABOLIC SYNDROME;
   LIFE-SPAN; SACCHAROMYCES-CEREVISIAE; NUTRIENT AVAILABILITY; INCREASED
   DOSAGE; MICE; DEACETYLASE; EXPRESSION
AB The NAD+-dependent SIRT6 deacetylase is a therapeutic candidate against the emerging metabolic syndrome epidemic. SIRT6, whose deficiency in mice results in premature aging phenotypes and metabolic defects, was implicated in a calorie restriction response that showed an opposite set of phenotypes from the metabolic syndrome. To explore the role of SIRT6 in metabolic stress, wild type and transgenic (TG) mice overexpressing SIRT6 were fed a high fat diet. In comparison to their wild-type littermates, SIRT6 TG mice accumulated significantly less visceral fat, LDL-cholesterol, and triglycerides. TG mice displayed enhanced glucose tolerance along with increased glucose-stimulated insulin secretion. Gene expression analysis of adipose tissue revealed that the positive effect of SIRT6 overexpression is associated with down regulation of a selective set of peroxisome proliferator-activated receptor-responsive genes, and genes associated with lipid storage, such as angiopoietin-like protein 4, adipocyte fatty acid-binding protein, and diacylglycerol acyltransferase 1, which were suggested as potential targets for drugs to control metabolic syndrome. These results demonstrate a protective role for SIRT6 against the metabolic consequences of diet-induced obesity and suggest a potentially beneficial effect of SIRT6 activation on age-related metabolic diseases.
C1 [Kanfi, Yariv; Peshti, Victoria; Gil, Reuven; Naiman, Shoshana; Nahum, Liat; Cohen, Haim Y.] Bar Ilan Univ, Mina & Everard Goodman Fac Life Sci, IL-52900 Ramat Gan, Israel.
   [Levin, Eran; Kronfeld-Schor, Noga] Tel Aviv Univ, Dept Zool, IL-69978 Tel Aviv, Israel.
C3 Bar Ilan University; Tel Aviv University
RP Cohen, HY (corresponding author), Bar Ilan Univ, Mina & Everard Goodman Fac Life Sci, IL-52900 Ramat Gan, Israel.
EM cohenh6@mail.biu.ac.il
RI Kronfeld-Schor, Noga/AAU-3792-2020; Levin, Eran/GPF-5345-2022
OI Kronfeld-Schor, Noga/0000-0002-5224-3341; Cohen, Haim
   Y./0000-0002-6613-8710; Levin, Eran/0000-0002-9972-7028
FU Israeli Academy of Sciences; Binational US-Israel Science Foundation;
   Israel Cancer Association; Koret Foundation; Israel Cancer Research
   Fund; Israeli Ministry of Health; ERC: European Research Council
FX We thank Doron Ginsberg, Shelley Schwarzbaum (BIU, Israel) and members
   of the Cohen lab for their helpful comments on the manuscript. We also
   thank. J. Miyazaki (Osaka U., Japan) for pCAGGS plasmid, Amos Ar (TAU,
   Israel) for technical advices and Shay Shemesh (BIU, Israel) for
   technical assistance. This study was supported by grants from the
   Israeli Academy of Sciences, Binational US-Israel Science Foundation,
   Israel Cancer Association, Koret Foundation, the Israel Cancer Research
   Fund, the Israeli Ministry of Health and the ERC: European Research
   Council.
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NR 44
TC 248
Z9 287
U1 1
U2 26
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1474-9726
J9 AGING CELL
JI Aging Cell
PD APR
PY 2010
VL 9
IS 2
BP 162
EP 173
DI 10.1111/j.1474-9726.2009.00544.x
PG 12
WC Cell Biology; Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Geriatrics & Gerontology
GA 570KU
UT WOS:000275677000006
PM 20047575
OA hybrid
DA 2025-06-11
ER

PT J
AU Candido, W
   Eggen, AC
   Jalving, M
   Bosma, I
   Horinga, RD
   van Heuvelen, KC
   Hiltermann, TJN
   Oosting, S
   Racz, E
   van der Klauw, MM
   Reyners, AKL
   Nuver, J
AF Candido, Wellington
   Eggen, Annemarie Cecile
   Jalving, Mathilde
   Bosma, Ingeborg
   Horinga, Reinate D.
   van Heuvelen, Kelly C.
   Hiltermann, T. Jeroen N.
   Oosting, Sjoukje
   Racz, Emoke
   van der Klauw, Melanie M.
   Reyners, Anna K. L.
   Nuver, Janine
TI Quality of life, neurocognitive functioning, psychological issues,
   sexuality and comorbidity more than 2 years after commencing immune
   checkpoint inhibitor treatment
SO JOURNAL FOR IMMUNOTHERAPY OF CANCER
LA English
DT Article
DE QUALITY OF LIFE; Immune Checkpoint Inhibitors; Survivorship; COGNITION;
   Immune related adverse event - irAE
ID LONG-TERM SURVIVORS; 6-MINUTE WALK; CANCER; HEALTH; SCALE; PREVALENCE;
   INSTRUMENT; GUIDELINES; TRIALS; INDEX
AB Background Increasing numbers of patients diagnosed with advanced cancer survive long-term after treatment with immune checkpoint inhibitors (ICIs). To design adequate interventions for these survivors, knowledge regarding quality of life (QOL) and its association with long-term and late effects of ICI treatment is required. Therefore, this study aimed to evaluate QOL, neurocognitive function, psychological issues, sexuality, and comorbidities in patients surviving at least 2 years after commencing ICI treatment.Methods We performed a cross-sectional study in patients with stage III-IV melanoma, non-small cell lung cancer (NSCLC), urothelial cell carcinoma (UCC), or renal cell carcinoma (RCC) who survived at least 2 years after the start of ICIs. We assessed QOL, neurocognitive function, psychological issues, sexual function and comorbidity in survivors. Additionally, we evaluated QOL of informal caregivers.Results 132 survivors (70 melanoma, 50 NSCLC, 12 UCC or RCC) and 80 caregivers were included. Median age was 65 years (range 30-85) and 50 survivors were women (38%). Median time since start and cessation of ICI treatment was 33 (range 21-91) and 18 (range 0-68) months, respectively. Average survivor QOL was comparable to the reference population, but 37 (28%) survivors had poor QOL. Depression and anxiety were negatively correlated with all QOL domains. Although immune-related adverse events were common, there was no association with lower QOL. Caregiver and survivor QOL were only weakly related. Neurocognitive concerns and formally tested neurocognitive impairment were present in 22 (17%) and 13 (15%) survivors, respectively, and were not associated with a diagnosis of brain metastases. Men had a high prevalence of erectile dysfunction and low sexual satisfaction. Half of the survivors met the criteria for the metabolic syndrome.Conclusions At least 2 years after the start of ICI treatment, one-quarter of cancer survivors had a clinically relevant lower QOL. This was associated with symptoms of depression and anxiety, but not with immune-related adverse events. Sexual issues and metabolic syndrome are prevalent. Survivorship care should address these issues in this population.
C1 [Candido, Wellington; Jalving, Mathilde; Horinga, Reinate D.; van Heuvelen, Kelly C.; Oosting, Sjoukje; Reyners, Anna K. L.; Nuver, Janine] Univ Med Ctr Groningen, Med Oncol, Groningen, Netherlands.
   [Candido, Wellington; Jalving, Mathilde; Bosma, Ingeborg; Horinga, Reinate D.; van Heuvelen, Kelly C.; Hiltermann, T. Jeroen N.; Oosting, Sjoukje; Racz, Emoke; van der Klauw, Melanie M.; Reyners, Anna K. L.; Nuver, Janine] Univ Groningen, Groningen, Netherlands.
   [Eggen, Annemarie Cecile] St Antonius Hosp Nieuwegein, Dept Internal Med, Nieuwegein, Netherlands.
   [Bosma, Ingeborg] Univ Med Ctr Groningen, Dept Neurol, Groningen, Netherlands.
   [Hiltermann, T. Jeroen N.] Univ Med Ctr Groningen, Pulm Dis, Groningen, Netherlands.
   [Racz, Emoke] Univ Med Ctr Groningen, Dept Dermatol, Groningen, Netherlands.
   [van der Klauw, Melanie M.] Univ Med Ctr Groningen, Dept Endocrinol, Groningen, Netherlands.
C3 University of Groningen; University of Groningen; St. Antonius Hospital
   Utrecht; University of Groningen; University of Groningen; University of
   Groningen; University of Groningen
RP Nuver, J (corresponding author), Univ Med Ctr Groningen, Med Oncol, Groningen, Netherlands.; Nuver, J (corresponding author), Univ Groningen, Groningen, Netherlands.
EM w.candido@umcg.nl; annemarieeggen1@gmail.com; m.jalving@umcg.nl;
   i.bosma01@umcg.nl; r.d.horinga@umcg.nl; kelly.van.heuvelen@outlook.com;
   t.j.n.hiltermann@umcg.nl; s.oosting@umcg.nl; e.racz@umcg.nl;
   m.m.van.der.klauw@umcg.nl; a.k.l.reyners@umcg.nl; j.nuver@umcg.nl
RI , HiltermannTJN/ABA-9144-2021; Jalving, Mathilde/C-1925-2014; van der
   Klauw, M./A-2138-2014
OI Hiltermann, Thijo Jeroen Nicolaas/0000-0002-0665-2160; Oosting,
   Sjoukje/0000-0003-2754-6997; Jalving, Mathilde/0000-0002-9142-9050
FU Dutch Cancer Society (KWF) [RUG 2012- 5359]
FX This research stemmed from and was made possible by financial support
   from the Dutch Cancer Society (KWF fellowship RUG 2012- 5359).
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NR 59
TC 0
Z9 0
U1 0
U2 0
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
EI 2051-1426
J9 J IMMUNOTHER CANCER
JI J. Immunother. Cancer
PD MAR 27
PY 2025
VL 13
IS 3
AR e011168
DI 10.1136/jitc-2024-011168
PG 13
WC Oncology; Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Immunology
GA 0VQ1T
UT WOS:001457095900001
PM 40154959
OA gold
DA 2025-06-11
ER

PT J
AU Panchal, SK
   Ward, L
   Brown, L
AF Panchal, Sunil K.
   Ward, Leigh
   Brown, Lindsay
TI Ellagic acid attenuates high-carbohydrate, high-fat diet-induced
   metabolic syndrome in rats
SO EUROPEAN JOURNAL OF NUTRITION
LA English
DT Article
DE Cardiovascular remodelling; Ellagic acid; Metabolic syndrome;
   Non-alcoholic fatty liver disease; Obesity
ID NF-KAPPA-B; OXIDATIVE STRESS; NONALCOHOLIC STEATOHEPATITIS;
   INSULIN-RESISTANCE; MECHANISTIC CLUES; LIVER-DISEASE; INFLAMMATION;
   MODEL
AB Fruits and nuts may prevent or reverse common human health conditions such as obesity, diabetes and hypertension; together, these conditions are referred to as metabolic syndrome, an increasing problem. This study has investigated the responses to ellagic acid, present in many fruits and nuts, in a diet-induced rat model of metabolic syndrome.
   Eight- to nine-week-old male Wistar rats were divided into four groups for 16-week feeding with cornstarch diet (C), cornstarch diet supplemented with ellagic acid (CE), high-carbohydrate, high-fat diet (H) and high-carbohydrate, high-fat diet supplemented with ellagic acid (HE). CE and HE rats were given 0.8 g/kg ellagic acid in food from week 8 to 16 only. At the end of 16 weeks, cardiovascular, hepatic and metabolic parameters along with protein levels of Nrf2, NF-kappa B and CPT1 in the heart and the liver were characterised.
   High-carbohydrate, high-fat diet-fed rats developed cardiovascular remodelling, impaired ventricular function, impaired glucose tolerance, non-alcoholic fatty liver disease with increased protein levels of NF-kappa B and decreased protein levels of Nrf2 and CPT1 in the heart and the liver. Ellagic acid attenuated these diet-induced symptoms of metabolic syndrome with normalisation of protein levels of Nrf2, NF-kappa B and CPT1.
   Ellagic acid derived from nuts and fruits such as raspberries and pomegranates may provide a useful dietary supplement to decrease the characteristic changes in metabolism and in cardiac and hepatic structure and function induced by a high-carbohydrate, high-fat diet by suppressing oxidative stress and inflammation.
C1 [Panchal, Sunil K.; Brown, Lindsay] Univ So Queensland, Dept Biol & Phys Sci, Toowoomba, Qld 4350, Australia.
   [Panchal, Sunil K.] Univ Queensland, Sch Biomed Sci, Brisbane, Qld 4072, Australia.
   [Ward, Leigh] Univ Queensland, Sch Chem & Mol Biosci, Brisbane, Qld 4072, Australia.
C3 University of Southern Queensland; University of Queensland; University
   of Queensland
RP Brown, L (corresponding author), Univ So Queensland, Dept Biol & Phys Sci, Toowoomba, Qld 4350, Australia.
EM Lindsay.Brown@usq.edu.au
RI Ward, Leigh/L-4461-2019; Ward, Leigh/A-4834-2010
OI Panchal, Sunil K/0000-0001-5464-3376; Ward, Leigh/0000-0003-2378-279X
FU Prince Charles Hospital Foundation, Brisbane, QLD, Australia
FX This study was supported by Dr Red Nutraceuticals, Mt Nebo, QLD,
   Australia. This project was also partially funded by grants from The
   Prince Charles Hospital Foundation, Brisbane, QLD, Australia. We thank
   Mr. Paul Addison, School of Biomedical Sciences, and Mr. Brian Bynon,
   School of Veterinary Science, both at The University of Queensland, for
   their help with histopathological studies and plasma biochemical
   analyses, respectively. We also thank Dr. Thiruma V. Arumugam, School of
   Biomedical Sciences, The University of Queensland, for his assistance
   with Western blot analysis and Dr. Fiona Campbell, School of Veterinary
   Science, The University of Queensland, for her assistance with
   echocardiography.
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NR 41
TC 127
Z9 134
U1 2
U2 81
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1436-6207
EI 1436-6215
J9 EUR J NUTR
JI Eur. J. Nutr.
PD MAR
PY 2013
VL 52
IS 2
BP 559
EP 568
DI 10.1007/s00394-012-0358-9
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 090HR
UT WOS:000314970600013
PM 22538930
DA 2025-06-11
ER

PT J
AU Behl, TA
   Stamford, BA
   Moffatt, RJ
AF Behl, Taylor A.
   Stamford, Bryant A.
   Moffatt, Robert J.
TI The Effects of Smoking on the Diagnostic Characteristics of Metabolic
   Syndrome: A Review
SO AMERICAN JOURNAL OF LIFESTYLE MEDICINE
LA English
DT Review
DE Cigarette smoking; metabolic syndrome; obesity; hypertension; blood
   lipids; insulin resistance
ID NECROSIS-FACTOR-ALPHA; C-REACTIVE PROTEIN; AMBULATORY BLOOD-PRESSURE;
   CIGARETTE-SMOKING; INSULIN-RESISTANCE; LIPOPROTEIN-LIPASE; OXIDATIVE
   STRESS; WEIGHT-GAIN; BODY-WEIGHT; ADIPOSE-TISSUE
AB Metabolic syndrome is a growing epidemic that increases the risk for cardiovascular disease, diabetes, stroke, and mortality. It is diagnosed by the presence of three or more of the following risk factors: 1) obesity, with an emphasis on central adiposity, 2) high blood pressure, 3) hyperglycemia, 4) dyslipidemia, with regard to reduced high-density lipoprotein concentrations, and 5) dyslipidemia, with regard to elevated triglycerides. Smoking is one lifestyle factor that can increase the risk for metabolic syndrome as it has been shown to exert negative effects on abdominal obesity, blood pressure, blood glucose concentrations, and blood lipid profiles. Smoking may also negatively affect other factors that influence glucose and lipid metabolism including lipoprotein lipase, adiponectin, peroxisome proliferator-activated receptors, and tumor necrosis factor-alpha. Some of these smoking-related outcomes may be reversed with smoking cessation, thus reducing the risk for metabolic disease; however, metabolic syndrome risk may initially increase post cessation, possibly due to weight gain. Therefore, these findings warrant the need for more research on the development and efficacy of smoking prevention and cessation programs.
C1 [Behl, Taylor A.] Florida State Univ, Dept Nutr & Integrat Physiol, Tallahassee, FL 32306 USA.
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   [Moffatt, Robert J.] Human Performance Dev Grp, 3560 Velda Oaks Circle, Tallahassee, FL 32309 USA.
C3 State University System of Florida; Florida State University
RP Moffatt, RJ (corresponding author), Human Performance Dev Grp, 3560 Velda Oaks Circle, Tallahassee, FL 32309 USA.
EM rmoffatt@fsu.edu
OI Behl, Taylor/0000-0001-8821-6997
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NR 168
TC 17
Z9 18
U1 0
U2 8
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1559-8276
EI 1559-8284
J9 AM J LIFESTYLE MED
JI Am. J. Lifestyle Med.
PD MAY
PY 2023
VL 17
IS 3
SI SI
BP 397
EP 412
DI 10.1177/15598276221111046
EA JUN 2022
PG 16
WC Public, Environmental & Occupational Health
WE Emerging Sources Citation Index (ESCI)
SC Public, Environmental & Occupational Health
GA F4RC3
UT WOS:000822177400001
PM 37304742
OA Green Published
DA 2025-06-11
ER

PT J
AU Larsen, JR
   Svensson, CK
   Vedtofte, L
   Jakobsen, ML
   Jespersen, HS
   Jakobsen, MI
   Koyuncu, K
   Schjerning, O
   Nielsen, J
   Ekstrom, CT
   Holst, JJ
   Correll, CU
   Vilsboll, T
   Fink-Jensen, A
AF Larsen, Julie R.
   Svensson, Camilla K.
   Vedtofte, Louise
   Jakobsen, Mathilde Lund
   Jespersen, Hans Soe
   Jakobsen, Michelle I.
   Koyuncu, Kamuran
   Schjerning, Ole
   Nielsen, Jimmi
   Ekstrom, Claus T.
   Holst, Jens J.
   Correll, Christoph U.
   Vilsboll, Tina
   Fink-Jensen, Anders
TI High prevalence of prediabetes and metabolic abnormalities in overweight
   or obese schizophrenia patients treated with clozapine or olanzapine
SO CNS SPECTRUMS
LA English
DT Article
DE Antipsychotic; glucose metabolism; metabolic syndrome; prediabetes;
   schizophrenia
ID GLUCAGON-LIKE PEPTIDE-1; MAJOR DEPRESSIVE DISORDER; TYPE-2
   DIABETES-MELLITUS; WEIGHT-GAIN; CARDIOVASCULAR-DISEASE; CARDIOMETABOLIC
   RISK; INSULIN SENSITIVITY; ANTIPSYCHOTIC-DRUGS; BIPOLAR DISORDER;
   SECRETION
AB Objective To assess the prevalence of prediabetes and metabolic abnormalities among overweight or obese clozapine- or olanzapine-treated schizophrenia patients, and to identify characteristics of the schizophrenia group with prediabetes. Methods A cross-sectional study assessing the presence of prediabetes and metabolic abnormalities in schizophrenia clozapine- or olanzapine-treated patients with a body mass index (BMI) >= 27 kg/m2. Procedures were part of the screening process for a randomized, placebo-controlled trial evaluating liraglutide vs placebo for improving glucose tolerance. For comparison, an age-, sex-, and BMI-matched healthy control group without psychiatric illness and prediabetes was included. Prediabetes was defined as elevated fasting plasma glucose and/or impaired glucose tolerance and/or elevated glycated hemoglobin A1c. Results Among 145 schizophrenia patients (age = 42.1 years; males = 59.3%) on clozapine or olanzapine (clozapine/olanzapine/both: 73.8%/24.1%/2.1%), prediabetes was present in 69.7% (101 out of 145). While schizophrenia patients with and without prediabetes did not differ regarding demographic, illness, or antipsychotic treatment variables, metabolic abnormalities (waist circumference: 116.7 +/- 13.7 vs 110.1 +/- 13.6 cm, P = 0.007; triglycerides: 2.3 +/- 1.4 vs 1.6 +/- 0.9 mmol/L, P = 0.0004) and metabolic syndrome (76.2% vs 40.9%, P<0.0001) were significantly more pronounced in schizophrenia patients with vs without prediabetes. The age-, sex-, and BMI-matched healthy controls had significantly better glucose tolerance compared to both groups of patients with schizophrenia. The healthy controls also had higher levels of high-density lipoprotein compared to patients with schizophrenia and prediabetes. Conclusion Prediabetes and metabolic abnormalities were highly prevalent among the clozapine- and olanzapine-treated patients with schizophrenia, putting these patients at great risk for later type 2 diabetes and cardiovascular disease. These results stress the importance of identifying and adequately treating prediabetes and metabolic abnormalities among clozapine- and olanzapine-treated patients with schizophrenia.
C1 [Larsen, Julie R.; Svensson, Camilla K.; Jakobsen, Mathilde Lund; Jespersen, Hans Soe; Jakobsen, Michelle I.; Koyuncu, Kamuran; Fink-Jensen, Anders] Univ Copenhagen, Rigshosp, Psychiat Ctr Copenhagen, Edel Sauntes Alle 10, DK-2100 Copenhagen O, Denmark.
   [Vedtofte, Louise; Vilsboll, Tina] Univ Copenhagen, Gentofte Hosp, Ctr Diabet Res, Copenhagen, Denmark.
   [Schjerning, Ole; Nielsen, Jimmi] Aalborg Univ, Aalborg Univ Hosp, Psychiat, Aalborg, Denmark.
   [Ekstrom, Claus T.] Univ Copenhagen, Sect Biostat, Dept Publ Hlth, Copenhagen, Denmark.
   [Holst, Jens J.] Univ Copenhagen, Panum Inst, NNF Ctr Basic Metab Res, Copenhagen, Denmark.
   [Holst, Jens J.] Univ Copenhagen, Panum Inst, Dept Biomed Sci, Copenhagen, Denmark.
   [Correll, Christoph U.] Northwell Hlth, Zucker Hillside Hosp, Div Psychiat Res, Glen Oaks, NY USA.
   [Correll, Christoph U.] Hofstra Northwell Sch Med, Dept Psychiat & Mol Med, Hempstead, NY USA.
   [Correll, Christoph U.] Charite, Dept Child & Adolescent Psychiat, Berlin, Germany.
   [Vilsboll, Tina; Fink-Jensen, Anders] Univ Copenhagen, Fac Hlth & Med Sci, Dept Clin Med, Copenhagen, Denmark.
   [Vilsboll, Tina] Univ Copenhagen, Steno Diabet Ctr Copenhagen, Copenhagen, Denmark.
C3 University of Copenhagen; Rigshospitalet; University of Copenhagen;
   Herlev & Gentofte Hospital; Aalborg University; Aalborg University
   Hospital; University of Copenhagen; University of Copenhagen; University
   of Copenhagen; Northwell Health; Northwell Health; Berlin Institute of
   Health; Free University of Berlin; Humboldt University of Berlin;
   Charite Universitatsmedizin Berlin; University of Copenhagen; University
   of Copenhagen; Steno Diabetes Center
RP Fink-Jensen, A (corresponding author), Univ Copenhagen, Rigshosp, Psychiat Ctr Copenhagen, Edel Sauntes Alle 10, DK-2100 Copenhagen O, Denmark.
EM anders.fink-jensen@regionh.dk
RI Holst, Jens/AAA-8022-2022; Nielsen, Jimmi/G-2990-2010; Correll,
   Christoph/D-3530-2011; Ekstrøm, Claus/AGK-2967-2022; Vilsboll,
   Tina/I-6562-2016
OI Holst, Jens Juul/0000-0001-6853-3805; Jespersen, Hans Soe
   Riis/0000-0001-5391-9959; Jakobsen, Michelle Iris/0000-0002-8443-9074;
   Ekstrom, Claus Thorn/0000-0003-1191-373X; Vedtofte,
   Louise/0000-0003-0703-701X; Fink-Jensen, Anders/0000-0001-7143-1236;
   Nielsen, Jimmi/0000-0002-9868-7028
FU Capital Region Psychiatry Research Group; foundation of King Christian
   X; Novo Nordisk A/S
FX The study is an investigator-university initiated study (IIS), which
   received the liraglutide and the liraglutide placebo pens from Novo
   Nordisk A/S together with an unrestricted grant. The study received
   additional funding from the Capital Region Psychiatry Research Group and
   the foundation of King Christian X.
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NR 59
TC 21
Z9 23
U1 0
U2 17
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
SN 1092-8529
EI 2165-6509
J9 CNS SPECTRUMS
JI CNS Spectr.
PD AUG
PY 2019
VL 24
IS 4
BP 441
EP 452
DI 10.1017/S1092852918001311
PG 12
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA IL0WY
UT WOS:000477022100013
PM 30596361
DA 2025-06-11
ER

PT J
AU Rigamonti, AE
   Dei Cas, M
   Caroli, D
   De Col, A
   Cella, SG
   Paroni, R
   Sartorio, A
AF Rigamonti, Antonello E.
   Dei Cas, Michele
   Caroli, Diana
   De Col, Alessandra
   Cella, Silvano G.
   Paroni, Rita
   Sartorio, Alessandro
TI Identification of a Specific Plasma Sphingolipid Profile in a Group of
   Normal-Weight and Obese Subjects: A Novel Approach for a "Biochemical"
   Diagnosis of Metabolic Syndrome?
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE obesity; metabolic syndrome; sphingolipids; IDF diagnostic criteria
ID INDUCED INSULIN-RESISTANCE; CERAMIDE BIOSYNTHESIS; ACID
   SPHINGOMYELINASE; OXIDATIVE STRESS; INHIBITION; LIPOPROTEIN;
   INFLAMMATION; MYRIOCIN; DISEASE; SPHINGOSINE-1-PHOSPHATE
AB Metabolic syndrome is nosographically defined by using clinical diagnostic criteria such as those of the International Diabetes Federation (IDF) ones, including visceral adiposity, blood hypertension, insulin resistance and dyslipidemia. Due to the pathophysiological implications of the cardiometabolic risk of the obese subject, sphingolipids, measured in the plasma, might be used to biochemically support the diagnosis of metabolic syndrome. A total of 84 participants, including normal-weight (NW) and obese subjects without (OB-SIMET-) and with (OB-SIMET+) metabolic syndrome, were included in the study, and sphingolipidomics, including ceramides (Cer), dihydroceramides (DHCer), hexosyl-ceramides (HexCer), lactosyl-ceramides (LacCer), sphingomyelins (SM) and GM3 ganglosides families, and sphingosine-1-phosphate (S1P) and its congeners, was performed in plasma. Only total DHCers and S1P were significantly higher in OB-SIMET+ than NW subjects (p < 0.05), while total Cers decreased in both obese groups, though statistical significance was reached only in OB-SIMET- (vs. NW) subjects (p < 0.05). When considering the comparisons of the single sphingolipid species in the obese groups (OB-SIMET- or OB-SIMET+) vs. NW subjects, Cer 24:0 was significantly decreased (p < 0.05), while Cer 24:1, DHCer 16:0, 18:0, 18:1 and 24:1, and SM 18:0, 18:1 and 24:1 were significantly increased (p < 0.05). Furthermore, taking into account the same groups for comparison, HexCer 22:0 and 24:0, and GM3 22:0 and 24:0 were significantly decreased (p < 0.05), while HexCer 24:1 and S1P were significantly increased (p < 0.05). After having analyzed all data via a PLS-DA-based approach, the subsequent determination of the VIP scores evidenced the existence of a specific cluster of 15 sphingolipids endowed with a high discriminating performance (i.e., VIP score > 1.0) among the three groups, including DHCer 18:0, DHCer 24:1, Cer 18:0, HexCer 22:0, GM3 24:0, Cer C24:1, SM 18:1, SM 18:0, DHCer 18:1, HexCer 24:0, SM 24:1, S1P, SM 16:0, HexCer 24:1 and LacCer 22:0. After having run a series of multiple linear regressions, modeled by inserting each sphingolipid having a VIP score > 1.0 as a dependent variable, and waist circumference (WC), systolic/diastolic blood pressures (SBP/DBP), homeostasis model assessment-estimated insulin resistance (HOMA-IR), high-density lipoprotein (HDL), triglycerides (TG) (surrogates of IDF criteria) and C-reactive protein (CRP) (a marker of inflammation) as independent variables, WC was significantly associated with DHCer 18:0, DHCer 24:1, Cer 18:0, HexCer 22:0, Cer 24:1, SM 18:1, and LacCer 22:0 (p < 0.05); SBP with Cer 18:0, Cer 24:1, and SM 18:0 (p < 0.05); HOMA-IR with DHCer 18:0, DHCer 24:1, Cer 18:0, Cer 24:1, SM 18:1, and SM 18:0 (p < 0.05); HDL with HexCer 22:0, and HexCer 24:0 (p < 0.05); TG with DHCer 18:1, DHCer 24:1, SM 18:1, and SM 16:0 (p < 0.05); CRP with DHCer 18:1, and SP1 (p < 0.05). In conclusion, a cluster of 15 sphingolipid species is able to discriminate, with high performance, NW, OB-SIMET- and OB-SIMET+ groups. Although (surrogates of) the IDF diagnostic criteria seem to predict only partially, but congruently, the observed sphingolipid signature, sphingolipidomics might represent a promising "biochemical" support for the clinical diagnosis of metabolic syndrome.
C1 [Rigamonti, Antonello E.; Cella, Silvano G.] Univ Milan, Dept Clin Sci & Community Hlth, I-20129 Milan, Italy.
   [Dei Cas, Michele; Paroni, Rita] Univ Milan, Dept Hlth Sci, I-20142 Milan, Italy.
   [Caroli, Diana; De Col, Alessandra; Sartorio, Alessandro] Ist Ricovero & Cura Carattere Sci IRCCS, Ist Auxol Italiano, Expt Lab Auxoendocrinol Res, I-28824 Verbania, Italy.
   [Sartorio, Alessandro] Ist Ricovero & Cura Carattere Sci IRCCS, Ist Auxol Italiano, Expt Lab Auxoendocrinol Res, I-20145 Milan, Italy.
C3 University of Milan; University of Milan; IRCCS Istituto Auxologico
   Italiano; IRCCS Istituto Auxologico Italiano; Fondazione IRCCS Istituto
   Nazionale Tumori Milan
RP Rigamonti, AE (corresponding author), Univ Milan, Dept Clin Sci & Community Hlth, I-20129 Milan, Italy.
EM antonello.rigamonti@unimi.it; michele.deicas@unimi.it;
   d.caroli@auxologico.it; a.decol@auxologico.it; silvano.cella@unimi.it;
   rita.paroni@unimi.it; sartorio@auxologico.it
RI Rigamonti, Antonello/AAA-3238-2020; Caroli, Diana/AAA-4985-2020; PARONI,
   RITA/AAC-6265-2020; Dei Cas, Michele/AAO-2132-2020; PARONI,
   RITA/C-2955-2012; Rigamonti, Antonello Emilio/G-5287-2012; Sartorio,
   Alessandro/AAA-3581-2020
OI PARONI, RITA/0000-0002-3186-8860; Caroli, Diana/0000-0002-0727-7470; Dei
   Cas, Michele/0000-0001-7359-8558; Rigamonti, Antonello
   Emilio/0000-0002-2489-9108; Sartorio, Alessandro/0000-0002-9620-4133;
   cella, silvano/0000-0001-6884-3766
FU Italian Ministry of Health; University of Milan [RIPARTIAMO] [PSR 2020]
FX The research was funded by the Italian Ministry of Health. The grant
   "PSR 2020" by the University of Milan [RIPARTIAMO] was used to purchase
   kits and reagents.
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NR 71
TC 2
Z9 2
U1 3
U2 12
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD APR
PY 2023
VL 24
IS 8
AR 7451
DI 10.3390/ijms24087451
PG 18
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA F0MU8
UT WOS:000979382400001
PM 37108620
OA gold
DA 2025-06-11
ER

PT J
AU Yarmohammadi, F
   Mehri, S
   Najafi, N
   Amoli, SS
   Hosseinzadeh, H
AF Yarmohammadi, Fatemeh
   Mehri, Soghra
   Najafi, Nahid
   Amoli, Sanaz Salar
   Hosseinzadeh, Hossein
TI The protective effect of Azadirachta indica (neem) against
   metabolic A review
SO IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
LA English
DT Review
DE Azadirachta indica; Diabetes; Hyperlipidemia; Hypertension; Metabolic
   syndrome; Neem; Obesity
ID LEAF EXTRACT; ALPHA-GLUCOSIDASE; MEDICINAL-PLANTS; OXIDATIVE STRESS;
   BLOOD-PRESSURE; INSULIN ACTION; HYPOGLYCEMIC RESPONSES; INDUCED
   HYPERTENSION; DIABETIC-RATS; BETA-CELLS
AB Metabolic syndrome is a condition associated with obesity, diabetes, dyslipidemia, and high blood pressure. Recently, the use of phytochemicals is suggested in the control and treatment of metabolic syndrome. The Azadirachta indica (neem) is an evergreen tree belonging to the family of Meliaceae. Multiple studies have been confirmed the anti-diabetic and anti-hypertension, anti-hyperlipidemia, and anti-obesity effects of neem. In this review, we reported the protective effects of neem against the complications of metabolic syndrome with a special focus on mechanisms that are involved. It has been shown that neem can control hyperglycemia and hypertension through over-expression of transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) and anti-oxidant effects. Neem also reduced the glucose uptake through up-regulation of glucose transporter 4 (GLUT4) and inhibition of key intestinal enzymes such as glucosidases. Moreover, neem showed anti-hypertensive effects possibility via the block of calcium channels, up-regulation of endothelial nitric oxide synthase (eNOS), and extracellular signal-regulated kinases 1/2 (ERK1/2) signaling pathway. Anti-oxidant effects play an important role in protective mechanisms of neem against metabolic syndrome and its complications.
C1 [Yarmohammadi, Fatemeh; Najafi, Nahid; Amoli, Sanaz Salar] Mashhad Univ Med Sci, Student Res Comm, Mashhad, Razavi Khorasan, Iran.
   [Yarmohammadi, Fatemeh; Mehri, Soghra; Najafi, Nahid; Hosseinzadeh, Hossein] Mashhad Univ Med Sci, Sch Pharm, Dept Pharmacodynam & Toxicol, Mashhad, Razavi Khorasan, Iran.
   [Mehri, Soghra; Hosseinzadeh, Hossein] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Pharmaceut Res Ctr, Mashhad, Razavi Khorasan, Iran.
   [Amoli, Sanaz Salar; Hosseinzadeh, Hossein] Mashhad Univ Med Sci, Fac Med, Dept Clin Biochem, Mashhad, Razavi Khorasan, Iran.
C3 Mashhad University of Medical Sciences; Mashhad University of Medical
   Sciences; Mashhad University of Medical Sciences; Mashhad University of
   Medical Sciences
RP Hosseinzadeh, H (corresponding author), Mashhad Univ Med Sci, Sch Pharm, Dept Pharmacodynam & Toxicol, Mashhad, Razavi Khorasan, Iran.; Hosseinzadeh, H (corresponding author), Mashhad Univ Med Sci, Pharmaceut Technol Inst, Pharmaceut Res Ctr, Mashhad, Razavi Khorasan, Iran.
EM hosseinzadehh@mums.ac
RI Hosseinzadeh, Hossein/F-3013-2010; mehri, soghra/P-2939-2018;
   Yarmohammadi, Fatemeh/GQQ-1975-2022
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FU Mashhad University of Medical Sciences, Mashhad, Iran
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NR 137
TC 12
Z9 13
U1 0
U2 11
PU MASHHAD UNIV MED SCIENCES
PI MASHHAD
PA VICE-CHANCELLOR FOR RES CTR OFF IJBMS, DANESHGAH ST, PO BOX 9138813944 -
   445, MASHHAD, 00000, IRAN
SN 2008-3866
EI 2008-3874
J9 IRAN J BASIC MED SCI
JI Iran. J. Basic Med. Sci.
PD MAR
PY 2021
VL 24
IS 3
BP 280
EP 292
DI 10.22038/ijbms.2021.48965.11218
PG 13
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA QP2RC
UT WOS:000623684900003
PM 33995939
DA 2025-06-11
ER

PT J
AU Lottenberg, AM
   Afonso, MD
   Lavrador, MSF
   Machado, RM
   Nakandakare, ER
AF Lottenberg, Ana Maria
   Afonso, Milessa da Silva
   Ferrari Lavrador, Maria Silvia
   Machado, Roberta Marcondes
   Nakandakare, Edna Regina
TI The role of dietary fatty acids in the pathology of metabolic syndrome
SO JOURNAL OF NUTRITIONAL BIOCHEMISTRY
LA English
DT Review
DE Dietary fatty acids; Metabolic syndrome; Inflammation; Steatosis;
   Adipose tissue metabolism; Lipid metabolism
ID ELEMENT-BINDING PROTEIN; DENSITY-LIPOPROTEIN RECEPTOR;
   CARDIOVASCULAR-DISEASE RISK; AMERICAN-HEART-ASSOCIATION;
   LIVER-X-RECEPTOR; ENDOPLASMIC-RETICULUM STRESS; ADIPOSE-TISSUE
   INFLAMMATION; HEPATIC APOLIPOPROTEIN-B; VERY-LOW-DENSITY; MESSENGER-RNA
AB Dysfunctional lipid metabolism is a key component in the development of metabolic syndrome, a very frequent condition characterized by dyslipidemia, insulin resistance, abdominal obesity and hypertension, which are related to an elevated risk for type 2 diabetes mellitus. The prevalence of metabolic syndrome is strongly associated with the severity of obesity; its physiopathology is related to both genetics and food intake habits, especially the consumption of a high-caloric, high-fat and high-carbohydrate diet. With the progress of scientific knowledge in the field of nutrigenomics, it was possible to elucidate how the majority of dietary fatty acids influence plasma lipid metabolism and also the genes expression involved in lipolysis and lipogenesis within hepatocytes and adipocytes. The aim of this review is to examine the relevant mechanistic aspects of dietary fatty acids related to blood lipids, adipose tissue metabolism, hepatic fat storage and inflammatory process, all of them closely related to the genesis of metabolic syndrome. (C) 2012 Elsevier Inc. All rights reserved.
C1 [Lottenberg, Ana Maria; Afonso, Milessa da Silva; Ferrari Lavrador, Maria Silvia; Machado, Roberta Marcondes; Nakandakare, Edna Regina] Univ Sao Paulo, Fac Med Sci, BR-01246000 Sao Paulo, Brazil.
C3 Universidade de Sao Paulo
RP Lottenberg, AM (corresponding author), Univ Sao Paulo, Fac Med Sci, BR-01246000 Sao Paulo, Brazil.
EM amlottenberg@uol.com.br
RI Lottenberg, Ana/N-2531-2017; Nakandakare, Edna/D-6625-2012; Afonso,
   Milessa/J-2078-2014
OI Machado, Roberta Marcondes/0000-0003-0566-6410; Afonso,
   Milessa/0000-0003-3435-0722
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NR 175
TC 164
Z9 177
U1 0
U2 81
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0955-2863
EI 1873-4847
J9 J NUTR BIOCHEM
JI J. Nutr. Biochem.
PD SEP
PY 2012
VL 23
IS 9
BP 1027
EP 1040
DI 10.1016/j.jnutbio.2012.03.004
PG 14
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA 994BJ
UT WOS:000307905500001
PM 22749135
DA 2025-06-11
ER

PT J
AU Rettori, E
   De Laurentiis, A
   Dees, WL
   Endruhn, A
   Rettori, V
AF Rettori, Elisa
   De laurentiis, Andrea
   Dees, W. Les
   Endruhn, Axel
   Rettori, Valeria
TI Host Neuro- Immuno-Endocrine Responses In Periodontal Disease
SO CURRENT PHARMACEUTICAL DESIGN
LA English
DT Article
DE Gingiva; neuropeptides; inflammation; stress; endocannabinoids;
   cytokines
ID TOLL-LIKE RECEPTORS; GLUCOCORTICOID-RECEPTOR; CANNABINOID RECEPTOR;
   DIABETES-MELLITUS; METABOLIC SYNDROME; GENE-EXPRESSION; STRESS;
   INFLAMMATION; OXYTOCIN; ASSOCIATION
AB Periodontitis is a chronic inflammatory complex disease caused by microorganisms. It may be influenced by diverse systemic disorders, environmental, genetic and socio-psychological factors with the ability to alter the balance of the host neuro-immuno-endocrine responses. It is characterized by the progressive destruction of the tooth supporting apparatus leading to tooth loss, with possible impact on general health.
   Starting with a brief description of the periodontium, etiopathogenesis, repair processes and several physiological mechanisms and their disarray on periodontium response to bacterial challenge. Following, the negative effects of stress on the disease and some remarks on the recently discovered effects of oxytocin that modulate stress response and its role in individual coping mechanisms to stress. We also focus on the participation of components and functions of endocannabinoid system with anti-inflammatory actions on gingiva.
   Finally, a discussion that may link between diabetes, cardiovascular diseases, stroke and metabolic syndrome associated with periodontal disease; all of them sharing a common denominator that is inflammation and oxidative stress.
C1 [Rettori, Elisa; De laurentiis, Andrea; Rettori, Valeria] Univ Buenos Aires, Sch Med, CEFYBO CONICET UBA, Ctr Pharmacol & Bot Studies, RA-1053 Buenos Aires, DF, Argentina.
   [Dees, W. Les] Texas A&M Univ, Coll Vet Med, Dept Integrat Biosci, College Stn, TX 77845 USA.
   [Rettori, Elisa; Endruhn, Axel] Maimonides Univ, Sch Dent, Dept Periodontol, Buenos Aires, DF, Argentina.
C3 Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET);
   University of Buenos Aires; CONICET UBA; Texas A&M University System;
   Texas A&M University College Station
RP Rettori, E (corresponding author), UBA, CEFYBO CONICET UBA, Fac Med, Paraguay 2155 Piso 16,ABG1121, Buenos Aires, DF, Argentina.
EM elisarettori@yahoo.com.ar
FU Agencia Nacional de Promocion Cientifica y Tecnologica [PICT 06-0258];
   Consejo Nacional de Investigaciones Cientificas y Tecnicas [PIP 02546]
FX This research was partially supported by Grants from Agencia Nacional de
   Promocion Cientifica y Tecnologica PICT 06-0258 and Consejo Nacional de
   Investigaciones Cientificas y Tecnicas PIP 02546.
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NR 96
TC 14
Z9 14
U1 0
U2 14
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1381-6128
EI 1873-4286
J9 CURR PHARM DESIGN
JI Curr. Pharm. Design
PY 2014
VL 20
IS 29
BP 4749
EP 4759
PG 11
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA AN7TR
UT WOS:000340804200013
PM 24588827
DA 2025-06-11
ER

PT J
AU Denimal, D
   Nguyen, A
   de Barros, JPP
   Bouillet, B
   Petit, JM
   Vergès, B
   Duvillard, L
AF Denimal, Damien
   Nguyen, Amandine
   de Barros, Jean-Paul Pais
   Bouillet, Benjamin
   Petit, Jean-Michel
   Verges, Bruno
   Duvillard, Laurence
TI Major changes in the sphingophospholipidome of HDL in non-diabetic
   patients with metabolic syndrome
SO ATHEROSCLEROSIS
LA English
DT Article
DE HDL; Lipidomic; Metabolic syndrome; Phospholipids; Sphingolipids; Tandem
   mass spectrometry
ID ELEVATED OXIDATIVE STRESS; HIGH-DENSITY-LIPOPROTEINS;
   CORONARY-HEART-DISEASE; ESTER TRANSFER PROTEIN; OBESE SUBJECTS;
   DEFECTIVE FUNCTIONALITY; MYOCARDIAL-INFARCTION; INSULIN-RESISTANCE;
   PHYSICAL-ACTIVITY; IN-VIVO
AB Objective: Phospholipids and sphingolipids play a critical role in the protective effects of HDL against atherosclerosis. These properties are impaired in patients with metabolic syndrome, before the development of diabetes. We thus investigated whether HDL from patients with metabolic syndrome but normal fasting glycaemia present abnormalities in their sphingophospholipid profile.
   Methods: Using liquid chromatography/tandem mass spectrometry, we quantified the different species of the main phospholipids and sphingolipids in the HDL2 and HDL3 from 26 obese patients with metabolic syndrome but normal fasting glycaemia and 50 controls.
   Results: Phosphatidylcholines, when expressed as the relative amount compared with total phospholipids and sphingolipids, were similar in both HDL2 and HDL3 in the two groups. Lysophosphatidylcholines were 41% (p = 0.0002) and 86% (p < 0.0001) higher in HDL2 and HDL3, respectively, from patients with metabolic syndrome than in those from controls. Phosphatidylinositols were also higher in HDL2 and HDL3 (respectively, +60 and + 103% (p < 0.0001)). In contrast, both HDL2 and HDL3 from patients with metabolic syndrome showed lower proportions of phosphatidylethanolamine-based plasmalogens (respectively -78 and - 73%, p < 0.0001), phosphatidylcholine-based plasmalogens (respectively - 44 and - 53%, p < 0.0001), d18: 1-sphingosine-1-phosphate (respectively - 52 and - 38%, p < 0.0001) and sphingomyelins (respectively - 19% (p < 0.0001) and -24% (p = 0.0006)), than did controls. Moreover, we observed a decrease in C18: 2 fatty acid-containing phospholipids and an increase in C20: 4 fatty acid-containing phospholipids.
   Conclusion: The sphingophospholipidome of HDL from normoglycaemic obese patients with metabolic syndrome is profoundly modified, before the dysregulation of glycaemia. Most of the changes observed have pejorative effect in terms of vascular protection. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
C1 [Denimal, Damien; Bouillet, Benjamin; Petit, Jean-Michel; Verges, Bruno; Duvillard, Laurence] Univ Bourgogne, Natl Inst Hlth, Dijon, France.
   [Denimal, Damien; Bouillet, Benjamin; Petit, Jean-Michel; Verges, Bruno; Duvillard, Laurence] Univ Bourgogne, Med Res Unit 866, Dijon, France.
   [Denimal, Damien; Bouillet, Benjamin; Petit, Jean-Michel; Verges, Bruno; Duvillard, Laurence] Franche Comte, Fac Hlth Sci, Dijon, France.
   [Denimal, Damien; Duvillard, Laurence] Univ Hosp Dijon, Dept Biochem, Dijon, France.
   [Nguyen, Amandine; Bouillet, Benjamin; Petit, Jean-Michel; Verges, Bruno] Univ Hosp Dijon, Dept Endocrinol & Metab Dis, Dijon, France.
   [de Barros, Jean-Paul Pais] Univ Bourgogne, Lipid Platform, Dijon, France.
   [de Barros, Jean-Paul Pais] Franche Comte, Dijon, France.
C3 Universite Bourgogne Europe; Institut Agro; AgroSup Dijon; Universite
   Bourgogne Europe; Universite Bourgogne Europe; Universite Bourgogne
   Europe; CHU Dijon Bourgogne; Universite Bourgogne Europe; CHU Dijon
   Bourgogne; Institut Agro; AgroSup Dijon; Universite Bourgogne Europe
RP Duvillard, L (corresponding author), Plateau Tech Biol, Biochim Med, 2 Rue Angelique Ducoudray,BP 37013, F-21070 Dijon, France.
EM laurence.duvillard@chu-dijon.fr
RI Bouillet, Benjamin/AAG-8165-2019
OI DENIMAL, Damien/0000-0001-5454-954X; PAIS DE BARROS,
   Jean-Paul/0000-0002-5124-2283
FU University of Burgundy; Regional Council of Burgundy (Conseil Regional
   de Bourgogne); National Institute of Health and Medical Research
   (Institut National de la Sante et de la Recherche Medicale (INSERM))
FX This investigationwas supported by the University of Burgundy, the
   Regional Council of Burgundy (Conseil Regional de Bourgogne), and the
   National Institute of Health and Medical Research (Institut National de
   la Sante et de la Recherche Medicale (INSERM)).
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NR 47
TC 35
Z9 36
U1 0
U2 7
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0021-9150
EI 1879-1484
J9 ATHEROSCLEROSIS
JI Atherosclerosis
PD MAR
PY 2016
VL 246
BP 106
EP 114
DI 10.1016/j.atherosclerosis.2015.12.042
PG 9
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA DE3NY
UT WOS:000370538200016
PM 26773402
DA 2025-06-11
ER

PT J
AU Bilginoglu, A
AF Bilginoglu, Ayca
TI Cardiovascular protective effect of pioglitazone on oxidative stress in
   rats with metabolic syndrome
SO JOURNAL OF THE CHINESE MEDICAL ASSOCIATION
LA English
DT Article
DE Cardiovascular disease; Insulin resistance; Metabolic syndrome;
   Oxidative stress; Pioglitazone
ID AMELIORATES ENDOTHELIAL DYSFUNCTION; MYOCARDIAL-INFARCTION; ANTIOXIDANT;
   GAMMA; STREPTOZOTOCIN; ISOPRENALINE; THIOREDOXIN; GLUCOSE
AB Background: Although cardiovascular oxidative stress is examined in type 2 diabetes, there is relatively limited number of reports about the effect of pioglitazone, an insulin sensitizer, on cardiovascular oxidative stress in sucrose diet-induced metabolic syndrome (MetS). As a regulator of cardiovascular homeostasis, thioredoxin (TRX) has an important role in defense against oxidative stress in cardiovascular diseases. The purpose of this study is to investigate the role of pioglitazone on oxidative stress markers and TRX1 level in tissues of both heart and aorta from MetS rats.
   Methods: Male Wistar rats (200 to 250g in weight) were divided into three groups: control group, MetS group receiving drinking water including 935mM sucrose, and pioglitazone-treated MetS (MetS-P) group. Aspartate aminotransferase (AST), lactate dehydrogenase (LDH), total oxidant status (TOS), and total antioxidant status (TAS) levels were measured in serum and tissues using commercial kits. Malondialdehyde (MDA) and superoxide dismutase (SOD) were measured in serum and tissues for experimental groups. TRX1 protein level was measured by western blot.
   Results: The sucrose-fed rats exhibited several characteristics of MetS. In MetS group, AST, LDH, TOS, and MDA levels of heart and aorta tissues increased, whereas TAS and SOD levels of these tissues decreased. TRX1 protein level of heart and aorta tissues decreased in MetS group. Also, in the serum of experimental groups, AST, LDH, and TOS levels increased.
   Conclusion: Pioglitazone treatment significantly increased TRX1 protein level in heart and aorta tissues in MetS group. Pioglitazone affected the TRX1 protein level via regulation of reactive oxygen intermediates. Pioglitazone reduced the elevated oxidative stress in heart and aorta of MetS rats.
C1 [Bilginoglu, Ayca] Ankara Yildirim Beyazit Univ, Fac Med, Dept Biophys, Ankara, Turkey.
C3 Ankara Yildirim Beyazit University
RP Bilginoglu, A (corresponding author), Ankara Yildirim Beyazit Univ, Dept Biophys, Ankara, Turkey.
EM draycabilginoglu@hotmail.com
RI Bilginoglu Topcu, Ayca/J-8076-2018
OI BILGINOGLU, AYCA/0000-0002-1657-2607
FU Ankara Yildirim Beyazit University [TUBITAK-SBAG-115S827]; 
   [Office-2864]
FX This work was supported by TUBITAK-SBAG-115S827 and Ankara Yildirim
   Beyazit University Projects Office-2864.
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NR 28
TC 13
Z9 16
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1726-4901
EI 1728-7731
J9 J CHIN MED ASSOC
JI J. Chin. Med. Assoc.
PD JUN
PY 2019
VL 82
IS 6
BP 452
EP 456
DI 10.1097/JCMA.0000000000000103
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA IQ4HW
UT WOS:000480712700003
PM 30932940
OA hybrid
DA 2025-06-11
ER

PT J
AU Egea, MB
   Fernandes, SS
AF Egea, Mariana Buranelo
   Fernandes, Sibele Santos
TI Unlocking the Potential of Chia Intake in the Management of Metabolic
   Syndrome and its Risk Conditions: A Narrative Review
SO PLANT FOODS FOR HUMAN NUTRITION
LA English
DT Review
DE Salvia hispanica; Salva; Overweight; Obesity;
   Triglyceridemia; Hypertension
ID SALVIA-HISPANICA L.; ALPHA-LINOLENIC ACID; C-REACTIVE PROTEIN;
   BLOOD-PRESSURE; DOSE-RESPONSE; FATTY-ACIDS; WEIGHT-LOSS;
   SUPPLEMENTATION; OVERWEIGHT; SEED
AB Metabolic syndrome is the occurrence of at least three of the five conditions diabetes, overweight and obesity, triglyceridemia, hypercholesterolemia, and hypertension. Dietary interventions have been one of the first lines of treatment indicated for improving conditions related to metabolic syndrome. The growing interest in plant-based diets and foods with health-promoting qualities has increased significantly. Due to its excellent nutritional and bioactive value, chia seeds have a significant market share, characterized by their high content of proteins, essential fatty acids, fiber, vitamins, minerals, phenolic compounds, and antioxidants. These constituents promote potential positive effects on improving health, especially blood pressure, and reducing oxidative stress and the inflammatory state installed by metabolic syndrome and its risk conditions. However, the ten studies in humans that were reviewed generally showed no effect on anthropometric parameters and biochemical parameters related to glucose and lipid homeostasis. Thus, although chia seeds have a high potential to combat metabolic syndrome, this review found few studies, highlighting a gap in the area and a possible future topic for researchers.
C1 [Egea, Mariana Buranelo] Goiano Fed Inst Educ Sci & Technol, Campus Rio Verde, Rio Verde, Go, Brazil.
   [Fernandes, Sibele Santos] Fed Univ Rio Grande, Sch Chem & Food, Lab Food Technol, Av Italy Km 8, BR-96203900 Carreiros, Rio Grande, Brazil.
C3 Instituto Federal de Goias (IFG); Universidade Federal do Rio Grande
RP Fernandes, SS (corresponding author), Fed Univ Rio Grande, Sch Chem & Food, Lab Food Technol, Av Italy Km 8, BR-96203900 Carreiros, Rio Grande, Brazil.
EM mariana.egea@ifgoiano.edu.br; sibele.fernandes@furg.br
RI Egea, Mariana/B-1889-2014
FU ValSe-Food-CYTED; Fundacao de Amparo a Pesquisa do Estado do Rio Grande
   do Sul (FAPERGS) [23/2551-0000855-6]; CNPq; FAPEG; CAPES [001]; FURG; IF
   Goiano;  [119RT0567]
FX This work was supported by grant la ValSe-Food-CYTED (Ref. 119RT0567),
   and the study was financed by the Fundacao de Amparo a Pesquisa do
   Estado do Rio Grande do Sul (FAPERGS-23/2551-0000855-6). The authors
   acknowledge financial support from CNPq, FAPEG, CAPES (001), FURG, and
   IF Goiano.
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NR 101
TC 0
Z9 0
U1 2
U2 2
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0921-9668
EI 1573-9104
J9 PLANT FOOD HUM NUTR
JI Plant Food Hum. Nutr.
PD JUN
PY 2025
VL 80
IS 2
AR 90
DI 10.1007/s11130-025-01331-w
PG 12
WC Plant Sciences; Chemistry, Applied; Food Science & Technology; Nutrition
   & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Chemistry; Food Science & Technology; Nutrition &
   Dietetics
GA 0HG8V
UT WOS:001447342500002
PM 40100517
DA 2025-06-11
ER

PT J
AU Lam, JCM
   Ip, MSM
AF Lam, Jamie C. M.
   Ip, Mary S. M.
TI Sleep & the metabolic syndrome
SO INDIAN JOURNAL OF MEDICAL RESEARCH
LA English
DT Review
DE Diabetes mellitus; hypertension; metabolic syndrome; obesity;
   obstructive sleep apnoea; sleep-disordered breathing; sleep disturbances
ID POSITIVE AIRWAY PRESSURE; CARDIOVASCULAR RISK-FACTORS; TYPE-2
   DIABETES-MELLITUS; CHRONIC INTERMITTENT HYPOXIA; RANDOMIZED
   CONTROLLED-TRIALS; AMBULATORY BLOOD-PRESSURE; PLACEBO-CONTROLLED TRIAL;
   APNEA-HYPOPNEA SYNDROME; MIDDLE-AGED MEN; INSULIN-RESISTANCE
AB Sleep is an essential part of our daily living, and sleep disturbances may intervene with the biological and physiological processes in human body leading to the development of metabolic dysfunction. Short sleep duration and poor sleep quality have adverse effects on metabolism and hormonal processes, contributing to increased cardiovascular risk. Obstructive sleep apnoea is a chronic condition characterized by repetitive upper airway collapse during sleep, causing intermittent hypoxaemia, recurrent arousals and sleep fragmentation. Sleep disturbances can increase sympathetic activity, provoke systemic inflammation and oxidative stress, and impair vascular endothelial function. Obstructive sleep apnoea is increasingly recognized to be an independent cardiovascular risk factor. There is intense research interest in the association between obstructive sleep apnoea and the metabolic syndrome - the constellation of inter-related metabolic derangements including central obesity, hypertension, insulin resistance and dyslipidaemia, which appears to directly promote the development of atherosclerosis. The underlying pathophysiologic pathways or mechanistic links between obstructive sleep apnoea and metabolic syndrome have not been well delineated. This article reviews the current knowledge of the relationship between sleep disturbances, sleep-disordered breathing and the metabolic syndrome in adults.
C1 [Lam, Jamie C. M.; Ip, Mary S. M.] Univ Hong Kong, Univ Dept Med, Queen Mary Hosp, Div Resp Med, Hong Kong, Hong Kong, Peoples R China.
C3 University of Hong Kong
RP Ip, MSM (corresponding author), Univ Hong Kong, Univ Dept Med, Queen Mary Hosp, Div Resp Med, 102 Pokfulam Rd, Hong Kong, Hong Kong, Peoples R China.
EM msmip@hkucc.hku.hk
RI Ip, Mary Sau Man/C-4284-2009
OI Ip, Mary Sau Man/0000-0002-8692-6933
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NR 111
TC 40
Z9 48
U1 0
U2 10
PU MEDKNOW PUBLICATIONS & MEDIA PVT LTD
PI MUMBAI
PA B-9, KANARA BUSINESS CENTRE, OFF LINK RD, GHAKTOPAR-E, MUMBAI, 400075,
   INDIA
SN 0971-5916
J9 INDIAN J MED RES
JI Indian J. Med. Res.
PD FEB
PY 2010
VL 131
IS 2
SI SI
BP 206
EP 216
PG 11
WC Immunology; Medicine, General & Internal; Medicine, Research &
   Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; General & Internal Medicine; Research & Experimental
   Medicine
GA 569XD
UT WOS:000275635200012
PM 20308746
DA 2025-06-11
ER

PT J
AU Lakshmy, R
AF Lakshmy, Ramakrishnan
TI Metabolic syndrome: Role of maternal undernutrition and fetal
   programming
SO REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
LA English
DT Review
DE Metabolic syndrome; Intrauterine growth retardation; Fetal programming;
   Macronutrients; Micronutrients
ID BODY-MASS INDEX; LOW-BIRTH-WEIGHT; INTRAUTERINE GROWTH-RETARDATION;
   PLASMA-CORTISOL CONCENTRATIONS; DEPENDENT DIABETES-MELLITUS; IMPAIRED
   GLUCOSE-TOLERANCE; PERINATAL IRON-DEFICIENCY; CORONARY-HEART-DISEASE;
   DIET-INDUCED OBESITY; C-REACTIVE PROTEIN
AB Development of metabolic syndrome is attributed to genes, dietary intake, physical activity and environmental factors. Fetal programming due to maternal nutrition is also an important factor especially in developing countries where intrauterine growth retardation followed by excess nutrition postnatally is causing mismatch predisposing individuals to development of metabolic syndrome and its components. Several epidemiological and animal studies have provided evidence for the link between intrauterine growth retardation and adult metabolic diseases. Deficiency of macronutrients, protein and carbohydrates, during pregnancy and gestation results in lower infant birth weight, a surrogate marker of fetal growth and subsequently insulin resistance, glucose intolerance, hypertension and adiposity in adulthood. The role of micronutrients is less extensively studied but however gaining attention with several recent studies focusing on this aspect. Several mechanisms have been proposed to explain the developmental origin of adult diseases important among them being alteration of hypothalamic pituitary axis, epigenetic regulation of gene expression and oxidative stress. All of these mechanisms may be acting at different time during gestation and contributing to development of metabolic syndrome in adulthood.
C1 All India Inst Med Sci, Dept Cardiac Biochem, New Delhi 110049, India.
C3 All India Institute of Medical Sciences (AIIMS) New Delhi
RP Lakshmy, R (corresponding author), All India Inst Med Sci, Dept Cardiac Biochem, New Delhi 110049, India.
EM lakshmy_ram@yahoo.com
RI Ramakrishnan, Lakshmy/AFJ-8522-2022
OI Ramakrishnan, Lakshmy/0000-0002-8582-3705
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NR 138
TC 55
Z9 62
U1 0
U2 45
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1389-9155
EI 1573-2606
J9 REV ENDOCR METAB DIS
JI Rev. Endocr. Metab. Disord.
PD SEP
PY 2013
VL 14
IS 3
BP 229
EP 240
DI 10.1007/s11154-013-9266-4
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 224JP
UT WOS:000324881200003
PM 24005943
DA 2025-06-11
ER

PT J
AU Paunovic, M
   Kotur-Stevuljevic, J
   Arsic, A
   Milosevic, M
   Todorovic, V
   Guzonjic, A
   Vucic, V
   Petrovic, S
AF Paunovic, Marija
   Kotur-Stevuljevic, Jelena
   Arsic, Aleksandra
   Milosevic, Maja
   Todorovic, Vanja
   Guzonjic, Azra
   Vucic, Vesna
   Petrovic, Snjezana
TI Antioxidative Effects of Black Currant and Cornelian Cherry Juices in
   Different Tissues of an Experimental Model of Metabolic Syndrome in Rats
SO ANTIOXIDANTS
LA English
DT Article
DE metabolic syndrome; polyphenols; black currant juice; cornelian cherry
   juice; oxidative stress; antioxidants
ID OXIDATIVE STRESS; URIC-ACID; PARAOXONASE ACTIVITY; HEPATIC STEATOSIS;
   HIGH-FRUCTOSE; ASSAY; ACTIVATION; GENERATION; MECHANISM; PRODUCTS
AB A Western-style diet, rich in fat and simple sugars, is the main risk factor for a significant number of chronic diseases and disorders, as well as for a progression of metabolic syndrome (MetS). One of the key mechanisms involved in MetS development is increased oxidative stress caused by the accumulation of body fat. Some dietary polyphenols have shown a protective role in preventing oxidative-stress-induced damage. We investigated the difference in the oxidative response of plasma, liver, and visceral adipose tissue in rats fed with a high-fat high-fructose (HFF) diet for ten weeks, and the effectiveness of polyphenol-rich juices (black currant (BC) and cornelian cherry (CC)) in HFF-diet-induced oxidative stress prevention. The most prominent impact of the HFF diet on redox parameters was recorded in the liver, whereas adipose tissue showed the most potent protection mechanisms against oxidative stress. Consumption of both juices decreased advanced oxidation protein product (AOPP) level in plasma, increased paraoxonase1 (PON1) activity in the liver, and significantly decreased total oxidative status (TOS) in adipose tissue. BC exerted stronger antioxidative potential than CC and decreased the superoxide anion radical (O-2(& BULL;-)) level in the liver. It also reduced TOS, total antioxidative status (TAS), and malondialdehyde (MDA) concentration in adipose tissue. The multiple linear regression analysis has shown that the best predictors of MetS development, estimated through the increase in visceral adiposity, were superoxide dismutase (SOD), AOPP, TOS, and TAS. The consumption of polyphenol-rich juices may provide a convenient approach for the systemic reduction of oxidative stress parameters.
C1 [Paunovic, Marija; Arsic, Aleksandra; Vucic, Vesna; Petrovic, Snjezana] Univ Belgrade, Inst Med Res, Natl Inst Republ Serbia, Ctr Res Excellence Nutr & Metab,Grp Nutrit Biochem, Belgrade 11000, Serbia.
   [Kotur-Stevuljevic, Jelena; Guzonjic, Azra] Univ Belgrade, Fac Pharm, Dept Med Biochem, Belgrade 11351, Serbia.
   [Milosevic, Maja] Univ Belgrade, Inst Med Res, Natl Inst Republ Serbia, Grp Neuroendocrinol, Belgrade 11000, Serbia.
   [Todorovic, Vanja] Univ Belgrade, Fac Pharm, Dept Bromatol, Belgrade 11221, Serbia.
C3 University of Belgrade; University of Belgrade; University of Belgrade;
   University of Belgrade
RP Vucic, V (corresponding author), Univ Belgrade, Inst Med Res, Natl Inst Republ Serbia, Ctr Res Excellence Nutr & Metab,Grp Nutrit Biochem, Belgrade 11000, Serbia.
EM marija.paunovic@imi.bg.ac.rs; jelena.kotur@pharmacy.bg.ac.rs;
   aleksandra.arsic@imi.bg.ac.rs; mmilosevic@imi.bg.ac.rs;
   vanja.todorovic@pharmacy.bg.ac.rs; azra.guzonjic@pharmacy.bg.ac.rs;
   vesna.vucic@imi.bg.ac.rs; snjezana.petrovic@imi.bg.ac.rs
RI Paunovic, Marija/ADR-4681-2022; Todorovic, Vanja/AGZ-3317-2022; vucic,
   vesna/AFN-8591-2022; Milosevic, Maja/HLG-7635-2023
OI Vucic, Vesna/0000-0002-8563-594X; Todorovic, Vanja/0000-0002-6449-6450;
   Milosevic, Maja/0000-0002-0985-0728; Arsic,
   Aleksandra/0000-0001-8498-9415; Paunovic, Marija/0000-0001-5148-7523
FU Ministry of Science, Technological Development, and Innovation of the
   Republic of Serbia [451-03-47/2023-01/200015]; University of
   Belgrade-Faculty of Pharmacy [451-03-47/2023-01/200161]
FX This work was supported by the Ministry of Science, Technological
   Development, and Innovation of the Republic of Serbia (No.
   451-03-47/2023-01/200015) and through Grant Agreement with University of
   Belgrade-Faculty of Pharmacy (No. 451-03-47/2023-01/200161).
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NR 65
TC 4
Z9 4
U1 3
U2 26
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD JUN
PY 2023
VL 12
IS 6
AR 1148
DI 10.3390/antiox12061148
PG 19
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA K1BO1
UT WOS:001013868400001
PM 37371879
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Goodman, E
   Must, A
   Daniels, SR
   Dolan, LM
AF Goodman, Elizabeth
   Must, Aviva
   Daniels, Stephen R.
   Dolan, Lawrence M.
TI Hostility and Adiposity Mediate Disparities in Insulin Resistance among
   Adolescents and Young Adults
SO JOURNAL OF PEDIATRICS
LA English
DT Article
ID CORONARY-HEART-DISEASE; SOCIOECONOMIC-STATUS; METABOLIC SYNDROME;
   RISK-FACTORS; PSYCHOSOCIAL CHARACTERISTICS; HEALTH BEHAVIORS; US
   ADOLESCENTS; CHILDREN; ASSOCIATION; STRESS
AB Objective This study explores whether the relationship between lower socioeconomic status and insulin resistance in adolescents is mediated by both physiological and psychological factors associated with increased cardiometabolic risk
   Study design School-based longitudinal cohort study of 1222 healthy, non-Hispanic black and white teens. Parent education (PE), youth-specific Cook-Medley hostility scale, waist circumference, height, weight, pubertal status, and fasting plasma insulin (FPI) were measured and FPI reassessed 1 year later. Regression analyses utilizing bootstrapping (n = 2000) were used to estimate the direct and indirect effects of PE on FPI and assess the role of hostility and adiposity while adjusting for covariates.
   Results Lower PE predicted higher FPI (B = -1.52, P =.003), as did hostility (B =.19, P =.002) and adiposity (waist circumference B =.44, P <.001, BMI B =.98, P <.001). The effect of PE on FPI was mediated by both hostility and adiposity. When adiposity and hostility were accounted for, the effect of PE on FPI decreased by 32% (B = -1.04, P =.04); the total indirect estimate was -.485 (95% CI, -.652, -.041). Hostility accounted for 36% of the meditational effect.
   Conclusions Lower PE influences insulin resistance through adiposity and hostility. Thus, interventions to reduce health disparities associated with insulin resistance should consider both physiological and psychological approaches. (J Pediatr 2010; 157:572-7).
C1 [Goodman, Elizabeth] Tufts Med Ctr, Floating Hosp Children, Boston, MA USA.
   [Must, Aviva] Tufts Univ, Sch Med, Dept Publ Hlth & Community Med, Boston, MA 02111 USA.
   [Daniels, Stephen R.] Denver Childrens Hosp, Dept Pediat, Denver, CO USA.
   Univ Colorado, Sch Med, Denver, CO USA.
   [Dolan, Lawrence M.] Cincinnati Childrens Hosp Med Ctr, Div Endocrinol, Cincinnati, OH USA.
C3 Tufts Medical Center; Floating Hospital For Children; Massachusetts
   Department of Public Health; Tufts University; Children's Hospital
   Colorado; University of Colorado System; University of Colorado Anschutz
   Medical Campus; University of Colorado Denver; Cincinnati Children's
   Hospital Medical Center
RP Goodman, E (corresponding author), MassGen Hosp Children, Ctr Child & Adolescent Hlth Policy, 50 Staniford St,Suite 901, Boston, MA 02114 USA.
EM egoodman3@partners.org
RI Daniels, Stephen/AEZ-9355-2022
OI Goodman, Elizabeth/0000-0002-9640-9884
FU NIH [HD41527, DK59183, M01RR 08084]
FX Supported by NIH grants HD41527, DK59183, and M01RR 08084. S.D. is a
   consultant to Abbott and Schering-Plough. The other authors declare no
   conflicts of interest.
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NR 38
TC 8
Z9 10
U1 0
U2 2
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0022-3476
EI 1097-6833
J9 J PEDIATR-US
JI J. Pediatr.
PD OCT
PY 2010
VL 157
IS 4
BP 572
EP U84
DI 10.1016/j.jpeds.2010.04.048
PG 7
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Pediatrics
GA 647YM
UT WOS:000281656800014
PM 20542297
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Tajbakhsh, N
   Sokoya, EM
AF Tajbakhsh, Negara
   Sokoya, Elke M.
TI Sirtuin 1 is upregulated in young obese Zucker rat cerebral arteries
SO EUROPEAN JOURNAL OF PHARMACOLOGY
LA English
DT Article
DE Cerebrovasculature; Endothelium; Metabolic syndrome; Nitric oxide;
   Oxidative stress; Sirtuin 1
ID NITRIC-OXIDE SYNTHASE; OXIDATIVE STRESS; METABOLIC SYNDROME;
   ENDOTHELIAL-CELLS; RESVERATROL; DYSFUNCTION; DEACETYLASE; RELAXATION;
   ACTIVATION; INDUCTION
AB Many diseases, including metabolic syndrome, are characterised by endothelial dysfunction mediated by reduced nitric oxide bioavailability and oxidative stress. Sit-Win 1 is a protein deacetylase that targets endothelial nitric oxide synthase resulting in enhanced nitric oxide bioavailability. Although it has been highlighted as a potential therapeutic target, we still have no understanding of vascular SIRT1 changes during obesity. Therefore, the aim of the present study was to measure vascular function, SIRT1 protein levels of expression and markers of oxidative stress in obese Zucker rats. Middle cerebral arteries born nondiabetic obese and lean Zucker rats were mounted in a pressure myograph to assess nitric oxide-dependent dilations. Western blotting was used to measure protein levels of SIRT1, p53, acetylated p53, eNOS, phosphorylated eNOS and markers of oxidative stress (nitrotyrosine, Nox4 and SOD2) in cerebral vascular tissue. SIRT1 expression was two-fold greater in both cerebral arteries and aorta horn obese compared to lean Zucker rats. Acetylation of p53 at the SIRT1-specific lysine 379 site was markedly decreased. At the same time, there was noted cerebral vascular impairment however markers of oxidative stress were not increased. In fact, Nox4 appeared to be downregulated in obesity. Thus, SIRT1 protein levels within the vasculature are greater in obese compared to lean Zucker rats and are associated with higher SIRT1 activity and lower Nox4 expression. We propose that the increased expression and activity of SIRT1 may be a vascular adaptive mechanism in obesity, aiming to prevent oxidative stress. (C) 2013 Elsevier B.V. All rights reserved,
C1 [Tajbakhsh, Negara] Flinders Univ S Australia, Disciplines Med Biotechnol, Sch Med, Bedford Pk, SA 5042, Australia.
   [Sokoya, Elke M.] Flinders Univ S Australia, Sch Med, Bedford Pk, SA 5042, Australia.
C3 Flinders University South Australia; Flinders University South Australia
RP Sokoya, EM (corresponding author), Flinders Med Ctr Flinders Drive, Room 6E136, Bedford Pk, SA 5042, Australia.
EM elke.sokoya@flinders.edu.au
RI Sokoya, Elke/D-2983-2011
OI Tajbakhsh, Negara/0000-0002-8755-4246; Sokoya, Elke/0000-0001-8509-2044
FU Flinders Medical Centre Foundation
FX We are grateful to Prof Greg Barritt for genotyping rats and the use of
   the Flinders Proteomics Facility. This work was supported by the
   Flinders Medical Centre Foundation (EMS).
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NR 38
TC 8
Z9 9
U1 0
U2 6
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0014-2999
EI 1879-0712
J9 EUR J PHARMACOL
JI Eur. J. Pharmacol.
PD DEC 5
PY 2013
VL 721
IS 1-3
BP 43
EP 48
DI 10.1016/j.ejphar.2013.09.057
PG 6
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 259QO
UT WOS:000327541600007
PM 24113524
DA 2025-06-11
ER

PT J
AU Osei, F
   Wippert, PM
   Block, A
AF Osei, Francis
   Wippert, Pia-Maria
   Block, Andrea
TI Allostatic Load and Metabolic Syndrome in Depressed Patients: A
   Cross-Sectional Analysis
SO DEPRESSION AND ANXIETY
LA English
DT Article
ID PHYSIOLOGICAL DYSREGULATION; URINARY EPINEPHRINE; CORTISOL-LEVELS;
   NERVOUS-SYSTEM; NEUROPEPTIDE-Y; ADIPOSE-TISSUE; STRESS; HEALTH; BRAIN;
   ASSOCIATION
AB Allostatic load (AL) is the cumulative wear and tear on the body due to the chronic adverse physical or psychosocial situations. The acute stress response activates the primary mediators of AL, which include cortisol, epinephrine (EPI), norepinephrine (NE), and dehydroepiandrosterone sulfate (DHEA-S). Secondary outcomes, such as metabolic syndrome (MetS), cardiovascular, and immune system changes, can result from long-term stress responses. Given these complex reactions to an acute stressor, a multidimensional stress assessment is required when investigating individual stress reactivity in an experimental setting. This study is aimed at examining the association between the primary mediators of AL and MetS in major depressive disorder (MDD) patients. MDD patients (n=164, age=18-65 years old) with MetS+ (n=46, weight=93.10 +/- 16.43 kg) and without MetS- (n=118, weight=73.08 +/- 15.22 kg) were analyzed cross-sectionally. Stepwise binary regression and Welch's t-test were used to find the associations and differences between the two groups. The regression analysis was fully adjusted for age, sex, and the Beck Depression Inventory-II score. In unadjusted model, cortisol (b=-0.003, p=0.034) was inversely associated with MetS. In fully adjusted model, EPI (b=-0.006, p=0.007) was inversely associated with MetS. However, significant differences (p=0.005) were observed for cortisol between MDD patients without MetS- (410.13 +/- 144.63 nmol/l) and MDD patients with MetS+ (340.90 +/- 132.98 nmol/l) with a small effect size (Cohen's d of 0.489). Significant differences (p=0.001) were observed for EPI between MDD patients without MetS- (185.67 +/- 124.44 pg/ml) and MDD patients with MetS+ (124.95 +/- 84.38 pg/ml) with a moderate effect size (Cohen's d of 0.530). These observations are of clinical importance for the management of MDD patients.
C1 [Osei, Francis; Wippert, Pia-Maria; Block, Andrea] Univ Potsdam, Dept Hlth & Phys Act, Med Sociol & Psychobiol, D-14469 Potsdam, Germany.
   [Wippert, Pia-Maria] Joint Fac Univ Potsdam Brandenburg Med Sch Theodor, Fac Hlth Sci, Muhlenberg 9, D-14476 Potsdam, Germany.
C3 University of Potsdam
RP Osei, F (corresponding author), Univ Potsdam, Dept Hlth & Phys Act, Med Sociol & Psychobiol, D-14469 Potsdam, Germany.
EM francis.osei@uni-potsdam.de; wippert@uni-potsdam.de;
   anblock@uni-potsdam.de
RI Wippert, Pia-Maria/AAJ-6989-2020; Osei, Francis/S-2442-2017
OI Osei, Francis/0000-0001-7633-2595; Block, Andrea/0000-0002-4819-2529
FU German Pension Fund Association [10-R-40.07.05.07.008]; Deutsche
   Forschungsgemeinschaft (DFG, German Research Foundation) [491466077];
   Central Research Grant for Innovative Ideas from the University of
   Potsdam; German Academic Exchange Services (DAAD) [57552340]; Projekt
   DEAL
FX The present study was funded by the German Pension Fund Association
   (10-R-40.07.05.07.008), the Open Access Publishing Fund by the Deutsche
   Forschungsgemeinschaft (DFG, German Research Foundation) (Projektnummer
   491466077), and the Central Research Grant for Innovative Ideas from the
   University of Potsdam. The present study was supported by a scholarship
   from German Academic Exchange Services (DAAD, grant number 57552340) to
   Francis Osei. Open Access funding was enabled and organized by Projekt
   DEAL.
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NR 101
TC 0
Z9 0
U1 1
U2 9
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1091-4269
EI 1520-6394
J9 DEPRESS ANXIETY
JI Depress. Anxiety
PD JUN 6
PY 2024
VL 2024
AR 1355340
DI 10.1155/2024/1355340
PG 15
WC Psychology, Clinical; Psychiatry; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA XT6R5
UT WOS:001263973800001
PM 40226750
OA hybrid
DA 2025-06-11
ER

PT J
AU Zhang, JJ
   Wang, XQ
   Zeng, Q
   Gao, N
   Zhang, XY
AF Zhang, Jian-Jun
   Wang, Xiao-Qian
   Zeng, Qun
   Gao, Na
   Zhang, Xiang-Yang
TI Prevalence and associated clinical factors for overweight and obesity in
   young first-episode and drug-naïve Chinese patients with major
   depressive disorder
SO FRONTIERS IN PSYCHIATRY
LA English
DT Article
DE overweight; obesity; major depressive disorder (MDD); young; first
   episode and drug naive (FEDN) patients
ID BODY-MASS INDEX; RISK-FACTORS; WAIST CIRCUMFERENCE; METABOLIC SYNDROME;
   ADULTS; OUTPATIENTS; EPISODE; GENDER; ONSET
AB BackgroundObesity and overweight are common in young patients with major depressive disorder (MDD). However, the prevalence and associated clinical factors of obesity/overweight in young first-episode and drug-naive (FEDN) MDD patients are rarely reported in China.MethodsA cross-sectional study of 917 young patients (aged 18-35 years) with FEDN MDD was performed. Demographic and clinical data were collected. Depression, anxiety, and psychotic symptoms were assessed using the Hamilton Depression Scale (HAMD), the Hamilton Anxiety Scale (HAMA), and the Positive and Negative Syndrome Scale (PANSS) positive subscale, respectively.ResultsAmong the young MDD patients, the prevalence of obesity and overweight was 4.14 and 52.89%, respectively. Compared to normal-weight patients, overweight patients were older, had a greater age of onset, and had higher TSH and TG levels. Male MDD patients had a higher risk of obesity than female patients. Compared to obese patients, normal-weight and overweight patients had significantly lower HAMD scores, TC levels, and rates of TSH abnormalities. Logistic regression analysis showed that age, age of onset, and sex were independently associated with obesity, and TSH was independently associated with both obesity and overweight, in young MDD patients.ConclusionOur findings suggest a high prevalence of overweight and obesity in young FEDN MDD patients. Several demographic and clinical variables are independently associated with overweight/obesity in these young MDD patients.
C1 [Zhang, Jian-Jun; Wang, Xiao-Qian] Shanxi Univ Chinese Med, Natl Int Joint Res Ctr Mol Chinese Med, Shanxi Key Lab Chinese Med Encephalopathy, Taiyuan, Peoples R China.
   [Zhang, Jian-Jun; Zhang, Xiang-Yang] Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China.
   [Zeng, Qun] Shanxi Univ Chinese Med, Coll Basic Med Sci, Jinzhong, Peoples R China.
   [Gao, Na] Chinese Peoples Liberat Army PLA Gen Hosp, Dept Cardiol, Med Ctr 2, Beijing, Peoples R China.
   [Gao, Na] Chinese Peoples Liberat Army PLA Gen Hosp, Natl Clin Res Ctr Geriatr Dis, Beijing, Peoples R China.
   [Zhang, Xiang-Yang] Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China.
C3 Shanxi University of Chinese Medicine; Shanxi University of Chinese
   Medicine; Chinese Academy of Sciences; University of Chinese Academy of
   Sciences, CAS
RP Zhang, XY (corresponding author), Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China.; Zhang, XY (corresponding author), Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China.
EM zhangxy@psych.ac.cn
RI Zhang, Xiangyang/ABC-7380-2022; Wang, Xiaoqian/AAL-6743-2021
OI Zhang, Xiangyang/0000-0003-3326-382X
FU The author(s) declare financial support was received for the research,
   authorship, and/or publication of this article. This work was supported
   by the Chinese National Programs for Brain Science and Brain-like
   Intelligence Technology (2021ZD0202102), the Na [2021ZD0202102]; Chinese
   National Programs for Brain Science and Brain-like Intelligence
   Technology [31871111]; National Natural Science Foundation of China
   [2020088]; Youth Innovation Promotion Association CAS
FX We are grateful to all the physicians and nurses who participated in
   this study.r The author(s) declare financial support was received for
   the research, authorship, and/or publication of this article. This work
   was supported by the Chinese National Programs for Brain Science and
   Brain-like Intelligence Technology (2021ZD0202102), the National Natural
   Science Foundation of China (31871111), Youth Innovation Promotion
   Association CAS (2020088). These sources had no further role in this
   study design, in the data collection and analysis, in the writing of the
   report, and in the decision to submit the paper for publication.
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NR 37
TC 1
Z9 1
U1 0
U2 5
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-0640
J9 FRONT PSYCHIATRY
JI Front. Psychiatry
PD OCT 18
PY 2023
VL 14
AR 1278566
DI 10.3389/fpsyt.2023.1278566
PG 8
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA W3PQ5
UT WOS:001090785500001
PM 37920541
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Ajala-Lawal, RA
   Aliyu, NO
   Ajiboye, TO
AF Ajala-Lawal, R. A.
   Aliyu, N. O.
   Ajiboye, T. O.
TI Betulinic acid improves insulin sensitivity, hyperglycemia, inflammation
   and oxidative stress in metabolic syndrome rats via PI3K/Akt pathways
SO ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
LA English
DT Article
DE Triterpenes; blood glucose; insulin resistance; hyperlipidaemia;
   antioxidants; pro-inflammatory cytokines; metabolic hormones
ID HIGH-FRUCTOSE-DIET; NONALCOHOLIC FATTY LIVER; HEPATIC STEATOSIS;
   RESISTANCE; OBESITY; GLUCOSE; SUPPLEMENTATION; DYSLIPIDEMIA;
   ADIPONECTIN; ANTIOXIDANT
AB This study investigated the influence of betulinic acid on high-fructose diet-induced metabolic syndrome in rats. Oral administration of betulinic acid significantly reversed high-fructose diet-mediated increase in body mass index and blood glucose. Furthermore, betulinic acid restored high-fructose diet-mediated alterations in metabolic hormones (insulin, leptin and adiponectin). Betulinic acid-mediated upregulation of protein kinase B (Akt) and phosphoinositde-3 kinase (PI3K) anulled high-fructose diet mediated depletion. Also, elevated tumour necrosis factor-alpha, interleukin-6 and -8 were significantly lowered. Administration of betulinic acid restored high-fructose diet-mediated increase in the levels of lipid profile parameters and indices of atherosclerosis, cardiac and cardiovascular diseases. High-fructose diet-mediated decrease in activities of antioxidant enzymes (superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase and glucose 6-phosphate dehydrogenase) and increase in oxidative stress biomarkers (reduced glutathione, lipid peroxidation products, protein oxidation and fragmented DNA) were significantly restored by the phenolic acids. Conclusively, betulinic acid improves insulin sensitivity, elevated blood glucose, inflammation and dyslipidaemia and oxidative stress in high-fructose diet-induced metabolic syndrome through the PI#Kand Akt pathways .
C1 [Ajala-Lawal, R. A.; Aliyu, N. O.; Ajiboye, T. O.] Nile Univ Nigeria, Coll Hlth Sci, Dept Med Biochem, Antioxidants Redox Biol & Toxicol Res Grp, Abuja, Nigeria.
RP Ajiboye, TO (corresponding author), Nile Univ Nigeria, Coll Hlth Sci, Dept Med Biochem, Antioxidants Redox Biol & Toxicol Res Grp, Abuja, Nigeria.; Ajiboye, TO (corresponding author), Nile Univ Nigeria, Coll Hlth Sci, Dept Med Biochem, Antioxidants Redox Biol & Toxicol Res Grp,FCT, Abuja, Nigeria.
EM ajiboyeyong@yahoo.com
RI Aliyu, Najeeb/HGU-9184-2022; Ajiboye, Taofeek/H-5383-2011
OI Aliyu, Najeeb/0000-0003-1802-3107
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NR 53
TC 33
Z9 37
U1 2
U2 53
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1381-3455
EI 1744-4160
J9 ARCH PHYSIOL BIOCHEM
JI Arch. Physiol. Biochem.
PD MAR 14
PY 2020
VL 126
IS 2
BP 107
EP 115
DI 10.1080/13813455.2018.1498901
PG 9
WC Biochemistry & Molecular Biology; Biophysics; Endocrinology &
   Metabolism; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Endocrinology &
   Metabolism; Physiology
GA KI1KR
UT WOS:000511106400003
PM 30288995
DA 2025-06-11
ER

PT J
AU Rondinella, D
   Raoul, PC
   Valeriani, E
   Venturini, I
   Cintoni, M
   Severino, A
   Galli, FS
   Mora, V
   Mele, MC
   Cammarota, G
   Gasbarrini, A
   Rinninella, E
   Ianiro, G
AF Rondinella, Debora
   Raoul, Pauline Celine
   Valeriani, Eleonora
   Venturini, Irene
   Cintoni, Marco
   Severino, Andrea
   Galli, Francesca Sofia
   Mora, Vincenzina
   Mele, Maria Cristina
   Cammarota, Giovanni
   Gasbarrini, Antonio
   Rinninella, Emanuele
   Ianiro, Gianluca
TI The Detrimental Impact of Ultra-Processed Foods on the Human Gut
   Microbiome and Gut Barrier
SO NUTRIENTS
LA English
DT Review
DE ultra-processed foods (UPFs); gut microbiome; gut barrier
ID METABOLIC SYNDROME; HEALTH; BOWEL; EMULSIFIERS; ADIPOSITY;
   PHOSPHATIDYLCHOLINE; INFLAMMATION; NUTRIENTS; FEATURES; DISEASES
AB Ultra-processed foods (UPFs) have become a widely consumed food category in modern diets. However, their impact on gut health is raising increasing concerns. This review investigates how UPFs impact the gut microbiome and gut barrier, emphasizing gut dysbiosis and increased gut permeability. UPFs, characterized by a high content of synthetic additives and emulsifiers, and low fiber content, are associated with a decrease in microbial diversity, lower levels of beneficial bacteria like Akkermansia muciniphila and Faecalibacterium prausnitzii, and an increase in pro-inflammatory microorganisms. These alterations in the microbial community contribute to persistent inflammation, which is associated with various chronic disorders including metabolic syndrome, irritable bowel syndrome, type 2 diabetes, and colorectal cancer. In addition, UPFs may alter the gut-brain axis, potentially affecting cognitive function and mental health. Dietary modifications incorporating fiber, fermented foods, and probiotics can help mitigate the effects of UPFs. Furthermore, the public needs stricter regulations for banning UPFs, along with well-defined food labels. Further studies are necessary to elucidate the mechanisms connecting UPFs to gut dysbiosis and systemic illnesses, thereby informing evidence-based dietary guidelines.
C1 [Rondinella, Debora; Valeriani, Eleonora; Venturini, Irene; Severino, Andrea; Galli, Francesca Sofia; Mora, Vincenzina; Mele, Maria Cristina; Cammarota, Giovanni; Gasbarrini, Antonio; Ianiro, Gianluca] Univ Cattolica Sacro Cuore, Dept Translat Med & Surg, I-00168 Rome, Italy.
   [Rondinella, Debora; Valeriani, Eleonora; Venturini, Irene; Severino, Andrea; Galli, Francesca Sofia; Mora, Vincenzina; Mele, Maria Cristina; Cammarota, Giovanni; Gasbarrini, Antonio; Ianiro, Gianluca] Fdn Policlin Univ Gemelli IRCCS, UOC CEMAD Ctr Malattie Apparat Digerente, Dept Med & Surg Sci, Med Interna & Gastroenterol, I-00168 Rome, Italy.
   [Rondinella, Debora; Valeriani, Eleonora; Venturini, Irene; Severino, Andrea; Cammarota, Giovanni; Gasbarrini, Antonio; Ianiro, Gianluca] Fdn Policlin Univ Agostino Gemelli IRCCS, Dept Med & Surg Sci, UOC Gastroenterol, I-00168 Rome, Italy.
   [Raoul, Pauline Celine; Cintoni, Marco; Mele, Maria Cristina; Rinninella, Emanuele] Fdn Policlin Univ Agostino Gemelli IRCCS, Dept Med & Surg Sci, Clin Nutr Unit, I-00168 Rome, Italy.
   [Raoul, Pauline Celine; Cintoni, Marco; Rinninella, Emanuele] Univ Cattolica Sacro Cuore, Human Nutr Res Ctr, I-00168 Rome, Italy.
C3 Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli;
   Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli;
   Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli;
   Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli;
   Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli
RP Gasbarrini, A (corresponding author), Univ Cattolica Sacro Cuore, Dept Translat Med & Surg, I-00168 Rome, Italy.; Gasbarrini, A (corresponding author), Fdn Policlin Univ Gemelli IRCCS, UOC CEMAD Ctr Malattie Apparat Digerente, Dept Med & Surg Sci, Med Interna & Gastroenterol, I-00168 Rome, Italy.; Gasbarrini, A (corresponding author), Fdn Policlin Univ Agostino Gemelli IRCCS, Dept Med & Surg Sci, UOC Gastroenterol, I-00168 Rome, Italy.
EM debora.rondinella@unicatt.it; antonio.gasbarrini@unicatt.it
RI Rinninella, Emanuele/I-9385-2019; Gasbarrini, Antonio/NAZ-7603-2025;
   Ianiro, Gianluca/K-5578-2016; Severino, Andrea/KJM-5961-2024
OI Ianiro, Gianluca/0000-0002-8318-0515; Severino,
   Andrea/0009-0005-2570-4914
FU Italian Ministry of Health; AIRC [30203]; Fondo Italiano per la Scienza
   of the Italian Ministry of Research; Fondazione Roma [FIS00001711]; 
   [2024]
FX GI was supported by the PNRR 2023 (project PNRR-POC-2023-12377319) of
   the Italian Ministry of Health, by the Next Gen Clinician Scientist 2024
   of the AIRC (project 30203), and by the Fondo Italiano per la Scienza of
   the Italian Ministry of Research (project FIS00001711). The staff of the
   Fondazione Policlinico Gemelli IRCCS thank the Fondazione Roma for the
   invaluable support to their scientific research, which is supported by
   the Ricerca Corrente 2024 of the Italian Ministry of Health. The funders
   had no role in study design, data collection and analysis, the decision
   to publish, or the preparation of the manuscript.
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NR 132
TC 4
Z9 4
U1 10
U2 10
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD MAR
PY 2025
VL 17
IS 5
AR 859
DI 10.3390/nu17050859
PG 20
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA Z9Z4R
UT WOS:001442398300001
PM 40077728
OA gold
DA 2025-06-11
ER

PT J
AU Christensen, MR
   Poulsen, HE
   Henriksen, T
   Weimann, A
   Ellervik, C
   Lynnerup, N
   Rungby, J
   Banner, J
AF Christensen, Martin Roest
   Poulsen, Henrik Enghusen
   Henriksen, Trine
   Weimann, Allan
   Ellervik, Christina
   Lynnerup, Niels
   Rungby, Jorgen
   Banner, Jytte
TI Elevated levels of 8-oxoGuo and 8-oxodG in individuals with severe
   mental illness - An autopsy-based study
SO FREE RADICAL BIOLOGY AND MEDICINE
LA English
DT Article
DE 8-oxoGuo; 8-oxodG; Oxidative stress; Severe mental illness;
   Schizophrenia; Bipolar disorder; Depression; Autopsy
ID OXIDATIVELY GENERATED DNA; MAJOR DEPRESSIVE DISORDER; RNA DAMAGE;
   CEREBROSPINAL-FLUID; METABOLIC SYNDROME; LIQUID-CHROMATOGRAPHY; BIPOLAR
   DISORDER; URINARY MARKERS; DNA/RNA DAMAGE; RISK-FACTORS
AB Elevated systemic oxidative stress levels of 8-oxoGuo and 8-oxodG have been reported in individuals with severe mental illness (SMI). As no previous studies have addressed the link between local levels of 8-oxoGuo and 8-oxodG in the central nervous system (CNS), measured in cerebrospinal fluid (CSF), and urinary systemic levels, we employed autopsy-based material to elucidate this aspect. Additionally, we investigated the impact of 8-oxoGuo and 8-oxodG levels on the prevalence of somatic co-morbidities.
   Based on post mortem samples from deceased individuals with SMI (N=107), we found significantly elevated urinary levels of both 8-oxoGuo and 8-oxodG compared to mentally healthy living controls. While we found an association between urinary and CSF 8-oxodG levels (r=0.50, P < 0.001), a similar correlation was not evident for 8-oxoGuo (r=0.15, P=0.16). Additionally, the two r-values were significantly different (P < 0.001). Neither marker in urine or CSF was associated with obesity-related variables, metabolic syndrome or type 2 diabetes. The post mortem interval did not affect the results, but the agonal phase seemingly introduced bias.
   This study provided novel insights into the cellular oxidative stress levels in individuals with SMI. We demonstrated that increased oxidative stress locally and systemically is correlated and is a clear phenomenon in SMI. Although post mortem measurements contain some weaknesses, our study indicates DNA as the main site of oxidative stress modifications in the CNS in SMI. This may provide novel opportunities for treatment modalities. Additionally, our study demonstrated the applicability of post mortem material investigating systemic and local 8-oxoGuo and 8-oxodG levels.
C1 [Christensen, Martin Roest; Lynnerup, Niels; Banner, Jytte] Univ Copenhagen, Dept Forens Med, Copenhagen, Denmark.
   [Poulsen, Henrik Enghusen; Henriksen, Trine; Weimann, Allan] Bispebjerg & Frederiksberg Hosp, Dept Clin Pharmacol, Copenhagen, Denmark.
   [Ellervik, Christina] Dept Prod Res & Innovat, Soro, Region Zealand, Denmark.
   [Ellervik, Christina] Univ Copenhagen, Fac Hlth & Med Sci, Copenhagen, Denmark.
   [Ellervik, Christina] Harvard Med Sch, Boston Childrens Hosp, Boston, MA USA.
   [Rungby, Jorgen] Bispebjerg & Frederiksberg Hosp, Dept Endocrinol, Copenhagen, Denmark.
C3 University of Copenhagen; University of Copenhagen; Bispebjerg Hospital;
   University of Copenhagen; Harvard University; Harvard University Medical
   Affiliates; Boston Children's Hospital; Harvard Medical School;
   University of Copenhagen; Bispebjerg Hospital
RP Christensen, MR (corresponding author), Univ Copenhagen, Dept Forens Med, Copenhagen, Denmark.
EM mrchristensen@protonmail.com
RI Ellervik, Christina/H-2977-2019; Rungby, Jørgen/AAQ-4332-2021
OI Poulsen, Henrik Enghusen/0000-0003-4242-9924; Christensen, Martin
   Roest/0000-0003-2463-6110; Ellervik, Christina/0000-0002-3088-4375
FU Danish Health Authority, "SATS-pulje", Denmark [7-604-10-11/5/KAD,
   3-3019-5/2/KAD]
FX The SURVIVE study received financial support from the Danish Health
   Authority, "SATS-pulje", Denmark, grant numbers 7-604-10-11/5/KAD and
   3-3019-5/2/KAD.
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NR 54
TC 11
Z9 11
U1 0
U2 5
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0891-5849
EI 1873-4596
J9 FREE RADICAL BIO MED
JI Free Radic. Biol. Med.
PD OCT
PY 2018
VL 126
BP 372
EP 378
DI 10.1016/j.freeradbiomed.2018.08.029
PG 7
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA GV0NQ
UT WOS:000445759000034
PM 30145229
DA 2025-06-11
ER

PT J
AU Marcellini, F
   Giuli, C
   Papa, R
   Tirabassi, G
   Faloia, E
   Boscaro, M
   Polito, A
   Ciarapica, D
   Zaccaria, M
   Mocchegiani, E
AF Marcellini, F.
   Giuli, C.
   Papa, R.
   Tirabassi, G.
   Faloia, E.
   Boscaro, M.
   Polito, A.
   Ciarapica, D.
   Zaccaria, M.
   Mocchegiani, E.
TI OBESITY AND BODY MASS INDEX (BMI) IN RELATION TO LIFE-STYLE AND
   PSYCHO-SOCIAL ASPECTS
SO ARCHIVES OF GERONTOLOGY AND GERIATRICS
LA English
DT Article
DE obesity; Binge eating disorder; elderly; body mass index
ID METABOLIC SYNDROME; PHYSICAL-ACTIVITY; ITALIAN ADULTS; MENTAL-HEALTH;
   OVERWEIGHT; HYPERTENSION; POPULATION; SMOKING; SOCIETY; PEOPLE
AB Obesity is increasing in middle-aged adults and the elderly. This multifactorial phenomenon may have different causes, such as incorrect nutritional and dietary habits, psycho-social aspects and sedentary life-style. It is becoming a serious problem, due also to the world's ageing society. The aim of this study is to provide preliminary results on BMI, life-style and psycho-social aspects in a sample of Italian subjects, which also assesses the relationship between obesity and psychological health. We hypothesize that obesity is related to many factors, such as life-style, behavioral, socio-economic, and psychological aspects. The sample was made up of 107 obese and non-obese subjects, aged 50-74. All participants were given a multidimensional assessment, which included anthropometric, psycho-social and life-style evaluation. As per the protocol a structured life-style questionnaire designed to gather information on anthropometric measurements, socioeconomic factors, physical activity, smoking, alcohol and food intake. The Symptom Checklist-90 (SCL-90) for the evaluation of a broad range of psychological problems and symptoms of psychopathology; the Binge Eating Scale (BES) for the assessment of disorders in the eating habits were administered. BMI was associated with age and education, socio-economic status and smoking in both genders. Psychological factors for obesity differed between overweight men and women. In conclusion, obesity and non-obesity appear as two different entities in some aspects. The increase in the prevalence of obesity in elderly subjects could lead to disability and age-related diseases. For this reason, greater insight of the factors related to the development of obesity is required to develop treatment strategies weight-loss prevention programs.
C1 [Marcellini, F.; Papa, R.] INRCA Italian Natl Inst Aging, Ctr Psychosocial Aspects Aging, Sci Technol Area, I-60124 Ancona, Italy.
   [Giuli, C.] INRCA Italian Natl Inst Aging, Unit Geriatr, I-63023 Fermo, Italy.
   [Tirabassi, G.; Faloia, E.; Boscaro, M.] Polytech Univ Marche, Div Endocrinol, I-60020 Ancona, Italy.
   [Polito, A.; Ciarapica, D.; Zaccaria, M.] Natl Res Inst Food & Nutr INRAN, I-00178 Rome, Italy.
   [Polito, A.; Ciarapica, D.; Zaccaria, M.] INRCA Italian Natl Inst Aging, Lab Nutrigenom & Immunosenescence, Sci Technol Area, I-60121 Ancona, Italy.
C3 IRCCS INRCA; IRCCS INRCA; Marche Polytechnic University; Consiglio per
   la Ricerca in Agricoltura e L'analisi Dell'economia Agraria (CREA);
   IRCCS INRCA
RP Marcellini, F (corresponding author), INRCA Italian Natl Inst Aging, Ctr Psychosocial Aspects Aging, Sci Technol Area, Via S Margherita 5, I-60124 Ancona, Italy.
EM f.marcellini@inrca.it
RI Ciarapica, Donatella/AAL-5111-2021; Polito, Angela/AAO-1596-2020;
   Polito, Angela/B-1363-2016; Giuli, Cinzia/K-1172-2016; Papa,
   Roberta/J-5312-2016
OI Ciarapica, Donatella/0000-0003-2428-416X; Polito,
   Angela/0000-0003-4898-796X; Giuli, Cinzia/0000-0001-8826-2467; BOSCARO,
   MARCO/0000-0003-2596-1652; Papa, Roberta/0000-0003-3827-5918
CR [Anonymous], TECHN REP SER WHO
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NR 45
TC 30
Z9 32
U1 0
U2 25
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0167-4943
EI 1872-6976
J9 ARCH GERONTOL GERIAT
JI Arch. Gerontol. Geriatr.
PY 2009
VL 49
SU 1
BP 195
EP 206
DI 10.1016/j.archger.2009.09.029
PG 12
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA 525AK
UT WOS:000272185300025
PM 19836633
DA 2025-06-11
ER

PT J
AU Beyca, HH
   Mesci, B
   Caklili, OT
   Mutlu, HH
   Oguz, A
AF Beyca, H. H.
   Mesci, B.
   Caklili, O. Telci
   Mutlu, H. H.
   Oguz, A.
TI NEUROPATHY ASSOCIATED WITH HYPERTRIGLYCERIDEMIA IN PATIENTS WITH
   METABOLIC SYNDROME
SO ACTA ENDOCRINOLOGICA-BUCHAREST
LA English
DT Article
DE hypertriglyceridemia; metabolic syndrome; neuropathy
ID PERIPHERAL NEUROPATHY; RISK-FACTORS; COMPLICATIONS; MONOFILAMENT;
   PREVALENCE; STRESS
AB Context. With more studies investigating effects of high serum lipid levels, new findings are emerging regarding the damage these biomolecules may cause.
   Aim. In this study we aimed to find a relation between neuropathy and hypertriglyceridemia in patients with metabolic syndrome (MS).
   Material and methods. One hundred and twenty subjects (Ninety subjects with metabolic syndrome and 30 healthy controls) were included in the study. Subjects with MS were divided into three groups. HbA1C levels of the subjects were < 5.7% in group A, >= 5.7% - < 6.5% in group B, and >= 6.5% - < 8.0% in group C. Pin-Prick test and Semmes-Weinstein Monofilament were used for neurological examination. Electromyography was performed to patients with neuropathy to support the diagnosis.
   Results. Neuropathy prevalence was found to be higher in the subjects with metabolic syndrome compared to control group. (9.9 %; 16.65 %; 23.31 % vs. 3.3%; in group A, group B, group C vs. healthy control group respectively) (p=-0.003 for group A, p=0.0002 for group B, p=0.0002 for group C). There was an association between triglyceride levels and neuropathy in group C.
   Conclusion. Patients with MS may have more neuropathy risk than we estimate.
C1 [Caklili, O. Telci] Medeniyet Univ, Gortepe Training & Res Hosp, Dept Internal Med, Fahrettin Kerim Gokay St, TR-34350 Istanbul, Turkey.
C3 Istanbul Medeniyet University
RP Caklili, OT (corresponding author), Medeniyet Univ, Gortepe Training & Res Hosp, Dept Internal Med, Fahrettin Kerim Gokay St, TR-34350 Istanbul, Turkey.
EM wattersonx@gmail.com
RI Caklili, Ozge/AAT-7733-2020; Mesci, Banu/N-8081-2013; Oguz,
   Aytekin/AAJ-2732-2021; Mutlu, Hacer/K-2108-2019
OI MESCI, BANU/0000-0002-1524-2809
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NR 18
TC 8
Z9 8
U1 0
U2 2
PU EDITURA ACAD ROMANE
PI BUCURESTI
PA CALEA 13 SEPTEMBRIE NR 13, SECTOR 5, BUCURESTI 050711, ROMANIA
SN 1841-0987
EI 1843-066X
J9 ACTA ENDOCRINOL-BUCH
JI Acta Endocrinol.
PD JAN-MAR
PY 2016
VL 12
IS 1
BP 26
EP 29
DI 10.4183/aeb.2016.26
PG 4
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA DH3DS
UT WOS:000372668300005
PM 31258796
OA Green Published
DA 2025-06-11
ER

PT J
AU Zhang, YZ
   Wu, HY
   Ma, RW
   Feng, B
   Yang, R
   Chen, XG
   Li, MX
   Cheng, LM
AF Zhang, Yu-zhen
   Wu, Hai-ying
   Ma, Run-wei
   Feng, Bo
   Yang, Rui
   Chen, Xiao-gang
   Li, Min-xiao
   Cheng, Li-ming
TI Machine Learning-Based predictive model for adolescent metabolic
   syndrome: Utilizing data from NHANES 2007-2016
SO SCIENTIFIC REPORTS
LA English
DT Article
DE Machine learning; Metabolic syndrome; Predictive model; Adolescents;
   NHANES
ID FATTY LIVER-DISEASE; OBESITY; CHILDHOOD; RISK; CONSEQUENCES
AB Metabolic syndrome (Mets) in adolescents is a growing public health issue linked to obesity, hypertension, and insulin resistance, increasing risks of cardiovascular disease and mental health problems. Early detection and intervention are crucial but often hindered by complex diagnostic requirements. This study aims to develop a predictive model using NHANES data, excluding biochemical indicators, to provide a simple, cost-effective tool for large-scale, non-medical screening and early prevention of adolescent MetS. After excluding adolescents with missing diagnostic variables, the dataset included 2,459 adolescents via NHANES data from 2007-2016. We used LASSO regression and 20-fold cross-validation to screen for the variables with the greatest predictive value. The dataset was divided into training and validation sets in a 7:3 ratio, and SMOTE was used to expand the training set with a ratio of 1:1. Based on the training set, we built eight machine learning models and a multifactor logistic regression model, evaluating nine predictive models in total. After evaluating all models using the confusion matrix, calibration curves and decision curves, the LGB model had the best predictive performance, with an AUC of 0.969, a Youden index of 0.923, accuracy of 0.978, F1 score of 0.989, and Kappa value of 0.800. We further interpreted the LGB model using SHAP, the SHAP hive plot showed that the predictor variables were, in descending order of importance, BMI age sex-specific percentage, weight, upper arm circumference, thigh length, and race. Finally, we deployed it online for broader accessibility. The predictive models we developed and validated demonstrated high performance, making them suitable for large-scale, non-medical primary screening and early warning of adolescent Metabolic syndrome. The online deployment of the model allows for practical use in community and school settings, promoting early intervention and public health improvement.
C1 [Zhang, Yu-zhen; Feng, Bo; Chen, Xiao-gang; Li, Min-xiao; Cheng, Li-ming] Kunming Childrens Hosp, Dept Anesthesiol, Kunming, Yunnan, Peoples R China.
   [Zhang, Yu-zhen; Feng, Bo; Chen, Xiao-gang; Li, Min-xiao; Cheng, Li-ming] Kunming Childrens Hosp, Surg Intens Care Unit, Kunming, Yunnan, Peoples R China.
   [Wu, Hai-ying] Kunming Med Univ, Dept Emergency, Affiliated Hosp 1, Kunming, Yunnan, Peoples R China.
   [Ma, Run-wei] Kunming Med Univ, Chinese Acad Med Sci, Affiliated Cardiovasc Hosp, Fuwai Yunnan Hosp,Dept Cardiac Surg, Kunming, Yunnan, Peoples R China.
   [Yang, Rui] Kunming Med Univ, Dept Clin Lab, Affiliated Hosp 3, Kunming, Yunnan, Peoples R China.
C3 Kunming Medical University; Chinese Academy of Medical Sciences - Peking
   Union Medical College; Kunming Medical University; Kunming Medical
   University
RP Cheng, LM (corresponding author), Kunming Childrens Hosp, Dept Anesthesiol, Kunming, Yunnan, Peoples R China.; Cheng, LM (corresponding author), Kunming Childrens Hosp, Surg Intens Care Unit, Kunming, Yunnan, Peoples R China.
EM Medcheng@163.com
RI Zhang, Yuzhen/MSX-2908-2025; Xiao, Hu/GMX-0258-2022
OI , zhang yu zhen/0009-0000-8983-2177
CR azeal123.shinyapps.io, Our Web Prediction Tool can be accessed at the following link
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NR 35
TC 0
Z9 0
U1 16
U2 16
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD JAN 25
PY 2025
VL 15
IS 1
AR 3274
DI 10.1038/s41598-025-88156-4
PG 13
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA T7A9O
UT WOS:001406498300018
PM 39863763
OA gold
DA 2025-06-11
ER

PT S
AU Virmania, A
   Binienda, ZK
   Ali, SF
   Gaetani, F
AF Virmania, Ashraf
   Binienda, Zbigniew K.
   Ali, Syed F.
   Gaetani, Franco
BE Slikker, W
   Andrew, RJ
   Trembly, B
TI Metabolic syndrome in drug abuse
SO NEUROPROTECTIVE AGENTS: EIGHTH INTERNATIONAL NEUROPROTECTION SOCIETY
   MEETING
SE Annals of the New York Academy of Sciences
LA English
DT Article; Proceedings Paper
CT 8th International Conference on Neuroprotective Agents
CY SEP 18-20, 2006
CL Mackinac Isl, MI
SP Int Neuroprotect Soc
DE nutrition; drug abuse; metabolic syndrome; L-carnitine;
   acetyl-L-carnitine; creatine; selenium; lipoic acid; resveratrol;
   cocaine; ecstasy; methamphetamine; polyunsaturated fatty acids; alcohol;
   brain; liver; metabolic compromise; metabolic modifier;
   hyperinsulinemia; hypertension; dyslipidemia; abdominal obesity; free
   radicals; reactive oxygen species; vitamins; zinc; thiamine;
   supplements; diabetes; amphetamines
ID ACETYL-L-CARNITINE; ALPHA-LIPOIC ACID; INSULIN-RESISTANCE;
   DIABETES-MELLITUS; GENETIC-DETERMINANTS; OXIDATIVE STRESS; RISK-FACTORS;
   FATTY LIVER; WEIGHT-GAIN; METHAMPHETAMINE
AB Drug abuse is associated with significant health risk. Whether drug abusers are at a higher risk of suffering the metabolic syndrome is not widely known. The metabolic syndrome is a cluster of metabolic abnormalities, including hyperinsulinemia, hypertension, dyslipidemia, and abdominal obesity, and is probably triggered by initial imbalances at the cellular level in various critical metabolic pathways. These initially small metabolic imbalances are believed to cascade with time and lead to larger problems. Some indications that drug abuse may increase the risk of the metabolic syndrome include the following:
   Drug-abusing patients have higher rates of diabetes complications.
   Substance abuse is a significant contributing factor for treatment noncompliance in diabetes.
   Nutrition education can enhance substance abuse treatment outcomes.
   Each type of drug/substance abuse has a unique profile of toxicity. For example, the amphetamines generally affect the cardiovascular and neurological systems, worsening the risk factors for the metabolic syndrome. Methamphetamine (meth) abusers suffer cognitive deficits and abnormal metabolic activity, which affect nutritional status. This condition is further worsened by a drastic reduction in oral health in meth abusers, resulting in improper chewing and, therefore, digestion. Nutritional deficiency in combination with drug abuse would increase the risk of developing the metabolic syndrome by increasing cell damage, augmenting excitotoxicity, reducing energy production, and lowering the antioxidant potential of the cells. Another potential risk factor in the development of the metabolic syndrome is genetic vulnerability, especially in combination with drug abuse and nutritional deficiencies. The strategies available to treat this problem include pharmacological agents as well as dietary antioxidants. Such measures may be useful in reducing drug abuse-related toxicity that may lead to the metabolic syndrome.
C1 [Virmania, Ashraf; Ali, Syed F.; Gaetani, Franco] Sigma Tau Hlth Sci, Res & Dev, I-00040 Pomezia, Italy.
   [Binienda, Zbigniew K.] US FDA, Natl Ctr Toxicol Res, Div Neurotoxicol, Neurophysiol Lab, Jefferson, AR USA.
   [Ali, Syed F.] US FDA, Natl Ctr Toxicol Res, Div Neurotoxicol, Neurochem Lab, Jefferson, AR USA.
C3 US Food & Drug Administration (FDA); US Food & Drug Administration (FDA)
RP Virmania, A (corresponding author), Sigma Tau Hlth Sci, Res & Dev, Via Treviso 4, I-00040 Pomezia, Italy.
EM ashraf.virmani@st-hs.it
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NR 123
TC 26
Z9 30
U1 2
U2 15
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN STREET, MALDEN 02148, MA USA
SN 0077-8923
BN 978-1-57331-685-9
J9 ANN NY ACAD SCI
JI Ann.NY Acad.Sci.
PY 2007
VL 1122
BP 50
EP 68
DI 10.1196/annals.1403.004
PG 19
WC Multidisciplinary Sciences; Neurosciences; Pharmacology & Pharmacy
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics; Neurosciences & Neurology;
   Pharmacology & Pharmacy
GA BHD20
UT WOS:000252267100004
PM 18077564
DA 2025-06-11
ER

PT J
AU Kaushik, AS
   Agarwal, V
   Kumar, N
   Rehman, M
   Chaudhary, R
   Srivastava, S
   Srivastava, S
   Mishra, V
AF Kaushik, Arjun Singh
   Agarwal, Vipul
   Kumar, Neeraj
   Rehman, Mujeeba
   Chaudhary, Rishabh
   Srivastava, Siddhi
   Srivastava, Sukriti
   Mishra, Vikas
TI Stimulation of auricular vagus nerve ameliorates chronic stress induced
   metabolic syndrome via activation of Sirtuin-6
SO BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
LA English
DT Article
DE Chronic unpredictable stress; Metabolic syndrome; Vagus nerve
   stimulation; Sirtuin-6
ID HEART-RATE-VARIABILITY; INSULIN-RESISTANCE; SIRT6; MECHANISMS; GLUCOSE;
   HOMEOSTASIS; MODULATION; MANAGEMENT; PATHWAY; IMPACT
AB Chronic stress is one of the potential causes of the progression of metabolic syndrome (MS). Chronic stress decreases the release of Sirtuin-6 (SIRT6), which regulates MS by controlling glucose, insulin, lipids, and hypertension. Vagus nerve stimulation (VNS) activates SIRT6 via the cholinergic anti-inflammatory pathway (CAP). However, the effectiveness of VNS therapy for treating MS induced by chronic stress has not yet been studied. In this study, we first validated a rat model of chronic unpredictable stress (CUS) and assessed the characteristic features of MS. The CUS rats were exposed to random stressors daily for 8 weeks. The stress response was then confirmed by behavioral alteration and elevated serum corticosterone levels in rats, as measured by various behavioral tests and an ELISA kit, respectively. The MS characteristics in CUS rats were assessed using measurements of fasting blood glucose (FBG), systolic blood pressure (SBP), lipid indices, insulin levels, and HOMAIR. The stressed animals demonstrated a rise in FBG, SBP, and insulin along with altered lipid indices. After CUS, the rats were treated with VNS (6 Hz, 1.0 ms, 6 V, for 40 min x 14 days, alternatively), and their metabolic activity and vagal flow were assessed. Moreover, SIRT6 and AMP-activated protein kinase (AMPK) expression in rats was also assessed by immunohistochemistry and mRNA expression of liver and pancreatic tissue. SIRT6 and AMPK expression was decreased in CUS animals. Interestingly, VNS treatment attenuated CUS induced MS- associated parameters. These results indicate that VNS may be a beneficial complementary and non- pharmacological method for managing CUS-associated MS.
C1 [Kaushik, Arjun Singh; Kumar, Neeraj; Rehman, Mujeeba; Chaudhary, Rishabh; Srivastava, Siddhi; Srivastava, Sukriti; Mishra, Vikas] Babasaheb Bhimrao Ambedkar Univ, Cent Univ, Dept Pharmaceut Sci, Raebareli Rd, Lucknow 226025, UP, India.
   [Agarwal, Vipul] MIT Coll Pharm, Ram Ganga Vihar Phase 2, Moradabad 244001, UP, India.
C3 Babasaheb Bhimrao Ambedkar University
RP Mishra, V (corresponding author), Babasaheb Bhimrao Ambedkar Univ, Cent Univ, Dept Pharmaceut Sci, Raebareli Rd, Lucknow 226025, UP, India.
EM dr.vikasmishra@bbau.ac.in
RI Kaushik, Arjun/HDO-4581-2022; Chaudhary, Rishabh/NCV-0370-2025
FU Indian Council of Medical Research (ICMR) Senior Research Fellowship
   [3/1/2 (05) /OBS/2022-NCD-II]
FX This work was supported by an Indian Council of Medical Research (ICMR)
   Senior Research Fellowship (File No. 3/1/2 (05) /OBS/2022-NCD-II)
   awarded to Arjun Singh Kaushik.
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NR 92
TC 1
Z9 1
U1 1
U2 1
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0006-291X
EI 1090-2104
J9 BIOCHEM BIOPH RES CO
JI Biochem. Biophys. Res. Commun.
PD APR 5
PY 2025
VL 756
AR 151567
DI 10.1016/j.bbrc.2025.151567
EA MAR 2025
PG 13
WC Biochemistry & Molecular Biology; Biophysics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics
GA 0BB2C
UT WOS:001443122400001
PM 40056501
DA 2025-06-11
ER

PT J
AU Marijnissen, RM
   Naudé, PJW
   Comijs, HC
   Schoevers, RA
   Voshaar, RCO
AF Marijnissen, Radboud M.
   Naude, Petrus J. W.
   Comijs, Hannie C.
   Schoevers, Robert A.
   Voshaar, Richard C. Oude
TI Waist circumference and Neutrophil Gelatinase-Associated Lipocalin in
   late-life depression
SO BRAIN BEHAVIOR AND IMMUNITY
LA English
DT Article
DE Waist-circumference; Obesity; Late-life Depression; Neutrophil
   Gelatinase-Associated Lipocalin
ID C-REACTIVE PROTEIN; BODY-MASS INDEX; METABOLIC SYNDROME; ABDOMINAL
   OBESITY; VISCERAL FAT; MAJOR DEPRESSION; OLDER PERSONS; SYMPTOMS;
   INFLAMMATION; ANXIETY
AB Both visceral obesity and depression are associated with impaired health and excess mortality, possibly through overlapping pathophysiological mechanisms like adipose tissue derived inflammatory markers. These results, however, are primarily based on population-based surveys, often restricted to a young population and depression severity scales instead of patients with established diagnosis of depressive disorder. We examined the relation between waist circumference and late-life depression using the baseline data of the Netherlands Study of Depression in Older people (NESDO). Psychopathology has been assessed with Composite International Diagnostic Interview version 2.1. Adjusted for age, sex, education, lifestyle (smoking, alcohol, physical activity), drug use, cognition and chronic diseases as well as adjusted for body mass index (BMI), analysis of covariance showed that depressed older patients (n = 376) had a significantly lower waist circumference (WC) compared to their non-depressed comparisons (n = 130): estimated marginal mean (SE) = 93.9 (0.5) versus 97.8 (0.8) cm (F = 15.9; df = 1467; p < .001). Multiple linear regression analyses within the depressed group showed that both, depression severity (Inventory of Depressive Symptoms) as well as duration-related depression characteristics (age of onset, duration of illness, life-time comorbid dysthymia), were associated with the WC. Only the severity of depressive symptoms remained significant after further adjusted for the BMI. Interestingly, a recently discovered adipokine, Neutrophil Gelatinase-Associated Lipocalin (NGAL), was associated with late-life depression, but only in the subgroup of patients with a pathologically increased WC.
   Population-based findings on the positive association between obesity and depressive symptoms can thus not be generalised to a clinical sample of depressed older patients. The impact of the WC on course and treatment outcome of late-life depression should be examined in clinical samples, taken into account the relative impact of the WC in proportion to the general level of obesity as indexed by the BMI and the role of adipokines. (C) 2014 Elsevier Inc. All rights reserved.
C1 [Marijnissen, Radboud M.] ProPersona, Dept Old Age Psychiat, Wolfheze Arnhem, Netherlands.
   [Marijnissen, Radboud M.; Schoevers, Robert A.; Voshaar, Richard C. Oude] Univ Groningen, Univ Med Ctr Groningen, Univ Ctr Psychiat, Groningen, Netherlands.
   [Marijnissen, Radboud M.; Schoevers, Robert A.; Voshaar, Richard C. Oude] Univ Groningen, Univ Med Ctr Groningen, Interdisciplinary Ctr Psychopathol Emot Regulat, Groningen, Netherlands.
   [Naude, Petrus J. W.] Univ Groningen, Univ Med Ctr Groningen, Dept Neurol, Groningen, Netherlands.
   [Naude, Petrus J. W.] Univ Groningen, Univ Med Ctr Groningen, Alzheimer Res Ctr, Groningen, Netherlands.
   [Comijs, Hannie C.] Vrije Univ Amsterdam Med Ctr, Dept Psychiat, GGZinGeest, Amsterdam, Netherlands.
   [Comijs, Hannie C.] Vrije Univ Amsterdam Med Ctr, Inst Extramural Med Res EMGO, Amsterdam, Netherlands.
C3 University of Groningen; University of Groningen; University of
   Groningen; University of Groningen; Vrije Universiteit Amsterdam; VU
   UNIVERSITY MEDICAL CENTER; Vrije Universiteit Amsterdam; VU UNIVERSITY
   MEDICAL CENTER
RP Marijnissen, RM (corresponding author), ProPersona, Dept Old Age Psychiat, Wolfheze 2, NL-6874 BE Wolfheze, Netherlands.
EM r.marijnissen@propersona.nl
RI Naude, Pieter/AAC-2565-2021
OI Oude Voshaar, Richard/0000-0003-1501-4774; Schoevers, Robert
   A/0000-0003-0760-9866; Naude, Pieter/0000-0003-4732-4523
FU Fonds NutsOhra; Stichting tot Steun VCVGZ; NARSAD The Brain and
   Behaviour Research Fund; VU University Medical Center; Leiden University
   Medical Center; University Medical Center Groningen; UMC St Radboud; GGZ
   inGeest; GG Net; GGZ Nijmegen; GGZ Rivierduinen; GGZ Rivierduinen,
   Lentis; Parnassia
FX The infrastructure for the NESDO study (http://nesdo.amstad.nl
   http://nesdo.amstad.nl) is funded through the Fonds NutsOhra, Stichting
   tot Steun VCVGZ, NARSAD The Brain and Behaviour Research Fund, and the
   participating universities and mental health care organizations (VU
   University Medical Center, Leiden University Medical Center, University
   Medical Center Groningen, UMC St Radboud, and GGZ inGeest, GG Net, GGZ
   Nijmegen, GGZ Rivierduinen, Lentis, and Parnassia).
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NR 62
TC 16
Z9 16
U1 0
U2 11
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0889-1591
EI 1090-2139
J9 BRAIN BEHAV IMMUN
JI Brain Behav. Immun.
PD MAR
PY 2014
VL 37
BP 231
EP 239
DI 10.1016/j.bbi.2013.12.021
PG 9
WC Immunology; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Neurosciences & Neurology; Psychiatry
GA AD2MY
UT WOS:000333071000025
PM 24407044
DA 2025-06-11
ER

PT J
AU Shih, MK
   Hou, CY
   Dong, CD
   Patel, AK
   Tsai, YH
   Lin, MC
   Xu, ZY
   Perumal, PK
   Kuo, CH
   Huang, CY
AF Shih, Ming-Kuei
   Hou, Chih-Yao
   Dong, Cheng-Di
   Patel, Anil Kumar
   Tsai, Yung-Hsiang
   Lin, Mei-Chun
   Xu, Zheng-Ying
   Perumal, Pitchurajan Krishna
   Kuo, Chia-Hung
   Huang, Chun-Yung
TI Production and Characterization of Durvillaea antarctica Enzyme
   Extract for Antioxidant and Anti-Metabolic Syndrome Effects
SO CATALYSTS
LA English
DT Article
DE antioxidant; Durvillaea antarctica; enzymatic extraction;
   fucose-containing sulfated polysaccharide; metabolic syndrome
ID ALPHA-GLUCOSIDASE INHIBITION; IN-VITRO ANTIOXIDANT; BROWN SEAWEEDS;
   ASSISTED EXTRACTION; DIABETES-MELLITUS; OXIDATIVE STRESS; FUCOIDAN;
   POLYSACCHARIDES; HYPERTENSION; AMYLASE
AB In this study, three enzyme hydrolysate termed Dur-A, Dur-B, and Dur-C, were produced from Durvillaea antarctica biomass using viscozyme, cellulase, and alpha-amylase, respectively. Dur-A, Dur-B, and Dur-C, exhibited fucose-containing sulfated polysaccharide from chemical composition determination and characterization by FTIR analyses. In addition, Dur-A, Dur-B, and Dur-C, had high extraction yields and low molecular weights. All extracts determined to have antioxidant activities by DPPH (2,2-diphenyl-1-picrylhydrazyl), ABTS (2,20-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt), and ferrous ion-chelating methods. All extracts were also able to positively suppress the activities of key enzymes involved in metabolic syndrome: angiotensin I-converting enzyme (ACE), alpha-amylase, alpha-glucosidase, and pancreatic lipase. In general, Dur-B exhibited higher antioxidant and higher anti-metabolic syndrome effects as compared to the other two extracts. Based on the above health promoting properties, these extracts (especially Dur-B) can be used as potential natural antioxidants and natural anti-metabolic syndrome agents in a variety of food, cosmetic, and nutraceutical products for health applications.
C1 [Shih, Ming-Kuei] Natl Kaohsiung Univ Hospitality & Tourism, Grad Inst Food Culture & Innovat, 1 Songhe Rd, Kaohsiung 812301, Taiwan.
   [Hou, Chih-Yao; Tsai, Yung-Hsiang; Lin, Mei-Chun; Xu, Zheng-Ying; Kuo, Chia-Hung; Huang, Chun-Yung] Natl Kaohsiung Univ Sci & Technol, Dept Seafood Sci, 142 Haijhuan Rd, Kaohsiung 81157, Taiwan.
   [Dong, Cheng-Di] Natl Kaohsiung Univ Sci & Technol, Dept Marine Environm Engn, 142 Haijhuan Rd, Kaohsiung 81157, Taiwan.
   [Dong, Cheng-Di] Natl Kaohsiung Univ Sci & Technol, Sustainable Environm Res Ctr, Dept Marine Environm Engn, 142 Haijhuan Rd, Kaohsiung 81157, Taiwan.
   [Dong, Cheng-Di; Patel, Anil Kumar; Perumal, Pitchurajan Krishna] Natl Kaohsiung Univ Sci & Technol, Inst Aquat Sci & Technol, 142 Haijhuan Rd, Kaohsiung 81157, Taiwan.
C3 National Kaohsiung University of Hospitality & Tourism; National
   Kaohsiung University of Science & Technology; National Kaohsiung
   University of Science & Technology; National Kaohsiung University of
   Science & Technology; National Kaohsiung University of Science &
   Technology
RP Kuo, CH; Huang, CY (corresponding author), Natl Kaohsiung Univ Sci & Technol, Dept Seafood Sci, 142 Haijhuan Rd, Kaohsiung 81157, Taiwan.
EM kuoch@nkust.edu.tw; cyhuang@nkust.edu.tw
RI Chen, Yung-Chung/GRY-3101-2022; Krishna Perumal,
   Pitchurajan/LRU-1711-2024; Shih, MK/AAP-1524-2021; HOU,
   CHIH/S-4983-2018; Kuo, Chia-Hung/I-6058-2012; Patel, Anil
   Kumar/HJY-0453-2023; Patel, Anil Kumar/K-4607-2015
OI Shih, Ming-Kuei/0000-0001-5830-8591; Hou, Chih-Yao/0000-0002-8007-6077;
   Huang, Chun-Yung/0000-0001-9117-1013; Krishna Perumal,
   Pitchurajan/0009-0002-6615-0397; Dong, Cheng-Di/0000-0002-4758-3739;
   Patel, Anil Kumar/0000-0002-7129-7548; Kuo,
   Chia-Hung/0000-0003-3445-5663
FU National Science and Technology Council, Taiwan [MOST
   111-2221-E-992-024, 110-2320B-992-001-MY3, 111-2622-E-992-002,
   111-2221-E-328-001-MY3]
FX This research was funded by grants provided by the National Science and
   Technology Council, Taiwan, grant numbers MOST 111-2221-E-992-024,
   awarded to Chun-Yung Huang; 110-2320B-992-001-MY3 and
   111-2622-E-992-002, awarded to Chih-Yao Hou; and 111-2221-E-328-001-MY3,
   awarded to Ming-Kuei Shih, respectively.
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NR 56
TC 9
Z9 9
U1 3
U2 29
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2073-4344
J9 CATALYSTS
JI Catalysts
PD OCT
PY 2022
VL 12
IS 10
AR 1284
DI 10.3390/catal12101284
PG 17
WC Chemistry, Physical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry
GA 5O4OH
UT WOS:000872454300001
OA gold
DA 2025-06-11
ER

PT J
AU Looijmans, A
   Jörg, F
   Bruggeman, R
   Schoevers, R
   Corpeleijn, E
AF Looijmans, Anne
   Jorg, Frederike
   Bruggeman, Richard
   Schoevers, Robert
   Corpeleijn, Eva
TI Design of the Lifestyle Interventions for severe mentally ill
   Outpatients in the Netherlands (LION) trial; a cluster randomised
   controlled study of a multidimensional web tool intervention to improve
   cardiometabolic health in patients with severe mental illness
SO BMC PSYCHIATRY
LA English
DT Article
DE Severe mental illness; Cardiometabolic health; Physical activity; Diet;
   Intervention; e-health; Web tool; Community-dwelling patients;
   Outpatients
ID BODY-MASS INDEX; PHYSICAL-ACTIVITY; WAIST CIRCUMFERENCE; WEIGHT-LOSS;
   PEOPLE; SCHIZOPHRENIA; DEPRESSION; EXERCISE; VALIDITY; BEHAVIOR
AB Background: The cardiometabolic health of persons with a severe mental illness (SMI) is alarming with obesity rates of 45-55% and diabetes type 2 rates of 10-15%. Unhealthy lifestyle behaviours play a large role in this. Despite the multidisciplinary guideline for SMI patients recommending to monitor and address patients' lifestyle, most mental health care professionals have limited lifestyle-related knowledge and skills, and (lifestyle) treatment protocols are lacking. Evidence-based practical lifestyle tools may support both patients and staff in improving patients' lifestyle. This paper describes the Lifestyle Interventions for severe mentally ill Outpatients in the Netherlands (LION) trial, to investigate whether a multidimensional lifestyle intervention using a web tool can be effective in improving cardiometabolic health in SMI patients.
   Methods/Design: The LION study is a 12-month pragmatic single-blind multi-site cluster randomised controlled trial. 21 Flexible Assertive Community Treatment (ACT) teams and eight sheltered living teams of five mental health organizations in the Netherlands are invited to participate. Per team, nurses are trained in motivational interviewing and use of the multidimensional web tool, covering lifestyle behaviour awareness, lifestyle knowledge, motivation and goal setting. Nurses coach patients to change their lifestyle using the web tool, motivational interviewing and stages-of-change techniques during biweekly sessions in a) assessing current lifestyle behaviour using the traffic light method (healthy behaviours colour green, unhealthy behaviours colour red), b) creating a lifestyle plan with maximum three attainable lifestyle goals and c) discussing the lifestyle plan regularly. The study population is SMI patients and statistical inference is on patient level using multilevel analyses. Primary outcome is waist circumference and other cardiometabolic risk factors after six and twelve months intervention, which are measured as part of routine outcome monitoring using standard protocols. Secondary outcomes include depressive and negative symptoms, cost-effectiveness, and barriers and facilitators in intervention implementation.
   Discussion: Adequate health care should target both mental health and lifestyle behaviours in SMI patients. This trial contributes by studying a 12-month multidimensional lifestyle intervention as a potential evidence based (nursing) tool for targeting multiple lifestyle behaviours in SMI patients.
C1 [Looijmans, Anne; Corpeleijn, Eva] Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, Hanzepl 1,POB 30-0019700, NL-9700 RB Groningen, Netherlands.
   [Looijmans, Anne; Jorg, Frederike; Bruggeman, Richard] Univ Groningen, Univ Med Ctr Groningen, Rob Giel Res Ctr, Groningen, Netherlands.
   [Jorg, Frederike] Friesland Mental Hlth Serv, Res Dept, Leeuwarden, Netherlands.
   [Bruggeman, Richard; Schoevers, Robert] Univ Groningen, Univ Med Ctr Groningen, Dept Psychiat, Groningen, Netherlands.
C3 University of Groningen; University of Groningen; University of
   Groningen
RP Looijmans, A (corresponding author), Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, Hanzepl 1,POB 30-0019700, NL-9700 RB Groningen, Netherlands.; Looijmans, A (corresponding author), Univ Groningen, Univ Med Ctr Groningen, Rob Giel Res Ctr, Groningen, Netherlands.
EM A.Looijmans@umcg.nl
RI Jörg, Frederike/B-1325-2014
OI Corpeleijn, Eva/0000-0002-2974-3305; Schoevers, Robert
   A/0000-0003-0760-9866
FU ZonMw [837001006]
FX Funding for this study is provided by ZonMw, Grant 837001006. ZonMw is
   an independent self-governing organisation, working closely with the
   Netherlands Organisation for Scientific Research (NWO). ZonMw is
   responsible for health care research. Contact information:
   info@zonmw.nl. ZonMw did not have a role in the study design;
   collection, management, analysis, and interpretation of data; writing of
   the report; and the decision to submit the report for publication, and
   does not have ultimate authority over any of these activities.
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NR 58
TC 15
Z9 15
U1 1
U2 40
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-244X
J9 BMC PSYCHIATRY
JI BMC Psychiatry
PD MAR 21
PY 2017
VL 17
AR 107
DI 10.1186/s12888-017-1265-7
PG 13
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA EQ9RW
UT WOS:000398423200004
PM 28327086
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Garcia, C
   Feve, B
   Ferré, P
   Halimi, S
   Baizri, H
   Bordier, L
   Guiu, G
   Dupuy, O
   Bauduceau, B
   Mayaudon, H
AF Garcia, C.
   Feve, B.
   Ferre, P.
   Halimi, S.
   Baizri, H.
   Bordier, L.
   Guiu, G.
   Dupuy, O.
   Bauduceau, B.
   Mayaudon, H.
TI Diabetes and inflammation: Fundamental aspects and clinical implications
SO DIABETES & METABOLISM
LA English
DT Review
DE Diabetes; Inflammation; Innate immunity; Obesity; Endoplasmic reticulum
   stress; Review
ID C-REACTIVE PROTEIN; ENDOPLASMIC-RETICULUM STRESS; NECROSIS-FACTOR-ALPHA;
   INNATE IMMUNE-SYSTEM; CORONARY-ARTERY-DISEASE; PANCREATIC BETA-CELLS;
   METABOLIC SYNDROME-X; NF-KAPPA-B; INSULIN-RESISTANCE; ADIPOSE-TISSUE
AB Aim.-The aim of this paper is to provide the fundamental background of the inflammation theory associated with type 2 diabetes, to discuss the clinical consequences of low-grade inflammation, particularly in terms of cardiovascular risk, and to infer some clinical therapeutic strategies deriving from drugs that already exist or are in development.
   Methods.-This non-exhaustive work is the result of a Pubmed(R) research, based on requests including the following keywords: diabetes, inflammation, innate immunity, obesity, reticulum endoplasmic stress, cytokines, endothelial dysfunction.
   Results.-Obesity and type 2 diabetes are linked with a low-grade inflammation state that reflects the activation of innate immunity where metabolic, environmental and genetic factors are implicated. The role of endoplasmic reticulum stress and unfold protein response is underlined. Inflammation markers are predictive for the risk to develop diabetes, and are associated with an increased cardiovascular risk. While lifestyle modifications are followed by an improvement in inflammation markers, treatments inferred from the inflammation theory are of great interest, although quite moderate effects on glycaemic control have been observed with some of them.
   Conclusion.-The development of molecules targeting different inflammatory mechanisms could lead in diabetic patients to improvement of both glycaemia and cardiovascular prognosis. (C) 2010 Elsevier Masson SAS. All rights reserved.
C1 [Garcia, C.; Baizri, H.; Bordier, L.; Guiu, G.; Dupuy, O.; Bauduceau, B.; Mayaudon, H.] Hop Instruct Armees Begin, Serv Endocrinol Diabetol, F-94160 St Mande, France.
   [Feve, B.] Univ Paris 11, CHU Bicetre, INSERM, U693, F-94270 Le Kremlin Bicetre, France.
   [Ferre, P.] Ctr Rech Biomed Cordeliers, INSERM, UMR S 871, F-75270 Paris 06, France.
   [Halimi, S.] CHU Grenoble, Clin Endocrinol Diabetol Nutr, F-38043 Grenoble 9, France.
C3 Universite Paris Saclay; Assistance Publique Hopitaux Paris (APHP);
   Hopital Universitaire Bicetre - APHP; Institut National de la Sante et
   de la Recherche Medicale (Inserm); Institut National de la Sante et de
   la Recherche Medicale (Inserm); Universite Paris Cite; Sorbonne
   Universite; Communaute Universite Grenoble Alpes; Universite Grenoble
   Alpes (UGA); CHU Grenoble Alpes
RP Garcia, C (corresponding author), Hop Instruct Armees Begin, Serv Endocrinol Diabetol, 69 Ave Paris, F-94160 St Mande, France.
EM garcia.cyril@free.fr
RI Ferre, Pascal/K-1250-2013
OI Ferre, Pascal/0000-0003-0115-7045; Feve, Bruno/0000-0001-6577-9009
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NR 105
TC 121
Z9 130
U1 0
U2 29
PU MASSON EDITEUR
PI MOULINEAUX CEDEX 9
PA 21 STREET CAMILLE DESMOULINS, ISSY, 92789 MOULINEAUX CEDEX 9, FRANCE
SN 1262-3636
EI 1878-1780
J9 DIABETES METAB
JI Diabetes Metab.
PD NOV
PY 2010
VL 36
IS 5
BP 327
EP 338
DI 10.1016/j.diabet.2010.07.001
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 695VE
UT WOS:000285399900002
PM 20851652
DA 2025-06-11
ER

PT J
AU Chen, XQ
   Zhang, Y
   Huang, CL
   Fu, TT
   Tao, QH
   Ma, LQ
   Wang, LP
AF Chen Xiaoqing
   Zhang Yong
   Huang Chunlai
   Fu Tingting
   Tao Qinghua
   Ma Liqiang
   Wang Liping
TI Efficacy of Huanglian root decoction () on kidney injury in rat's model
   of metabolic syndrome
SO JOURNAL OF TRADITIONAL CHINESE MEDICINE
LA English
DT Article
DE Coptis; berberine; metabolic syndrome; endoplasmic reticulum stress;
   oxidative stress
ID ENDOPLASMIC-RETICULUM STRESS; UNFOLDED PROTEIN RESPONSE;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; COPTIS-CHINENSIS; DISEASE;
   GLUCOSE; INFLAMMATION; BERBERINE; APOPTOSIS
AB OBJECTIVE: To evaluate the efficacy of Huanglian root decoction (HLD) on kidney injury in rat's model of metabolic syndrome (MetS), and investigate the possible mechanism.
   METHODS: A fructose-induced MetS rat model and human renal tubular epithelial cell-line model were used to compare the efficacy of HLD with that of berberine and tauroursodeoxycholic acid (TUDCA). Blood pressure, biochemical parameters, histopathological changes and the expression levels of oxidative stress markers were evaluated in the animal model at the end of an 8-week treatment regimen. Oxidative stress markers and molecules of the signal pathway of endoplasmic reticulum (ER) stress were evaluated in the human cell-line model.
   RESULTS: Levels of fasting insulin, systolic blood pressure and diastolic blood pressure were significantly decreased in rats in the Huanglian group compared to those in the MetS group (P < 0.05). Rats treated with HLD and TUDCA exhibited a significant reduction in blood levels of malondialdehyde compared to those in rats in the MetS group (P < 0.05). Significant increases in glutathione peroxidase in human tubular epithelial cells was found in the Huanglian group compared to that in the MetS group (14.02 vs 18.31, P < 0.05). The mRNA expression of protein kinase RNA-like endoplasmic reticulum kinase and eukaryotic translation initiation factor 2 alpha decreased significantly in Huanglian groups compared with that in the MetS group.
   CONCLUSION: HLD has therapeutic efficacy on kidney injury in the MetS rat's model, and is non-inferior to berberine and TUDCA. (C) 2021 JTCM. All rights reserved.
C1 [Chen Xiaoqing; Zhang Yong; Huang Chunlai; Fu Tingting; Tao Qinghua; Ma Liqiang; Wang Liping] 900th Hosp Joint Logist Support Force, Div Nephrol, PLA, Fuzhou 350025, Peoples R China.
RP Wang, LP (corresponding author), 900th Hosp Joint Logist Support Force, Div Nephrol, PLA, Fuzhou 350025, Peoples R China.
EM wlp03291122@126.com
RI Wang, Liping/B-2827-2012
FU National Natural Science Foundation [81373837]; Natural Science
   Foundation of Fujian province [2018J01184]
FX Supported by the National Natural Science Foundation-funded Project:
   Coptis Decoction Protects Renal Damage Caused by Metabolic Syndrome (No.
   81373837)and the Natural Science Foundation of Fujian province-funded
   Project: (the mechanical and clinical approach of the berberine
   treatment for renal damage caused by metabolic syndrome through
   regulating IRE1-XBP1 pathway) (No. 2018J01184)
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NR 40
TC 4
Z9 4
U1 0
U2 10
PU JOURNAL TRADITIONAL CHINESE MED
PI BEIJING
PA 16 NANXIAOJIE, DONGZHIMEN NEI, BEIJING, 100700, PEOPLES R CHINA
SN 0255-2922
EI 1577-7014
J9 J TRADIT CHIN MED
JI J. Tradit. Chin. Med.
PD FEB
PY 2021
VL 41
IS 1
DI 10.19852/j.cnki.jtcm.20201228.002
PG 8
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA QF7WD
UT WOS:000617101600014
PM 33522204
DA 2025-06-11
ER

PT J
AU Kim, M
   Kim, M
   Yoo, HJ
   Lee, SY
   Lee, SH
   Lee, JH
AF Kim, Minkyung
   Kim, Minjoo
   Yoo, Hye Jin
   Lee, Seung Yeon
   Lee, Sang-Hyun
   Lee, Jong Ho
TI Age-Specific Determinants of Pulse Wave Velocity among Metabolic
   Syndrome Components, Inflammatory Markers, and Oxidative Stress
SO JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
LA English
DT Article
DE Arterial stiffness; baPWV; Metabolic syndrome; Oxidative stress
ID ARTERIAL STIFFNESS; ASSOCIATION; PROTEIN; ADULTS
AB Aim: Pulse wave velocity (PWV) is thought to have different relationships with metabolic syndrome (MS) components, inflammatory markers, and oxidative stress, according to age. However, age-specific determinants of PWV have not yet been studied. We investigated age-dependent relationships among PWV and MS components, inflammatory markers, and oxidative stress.
   Methods: A total of 4,318 subjects were divided into 4 groups: 19-34 y (n=687), 35-44 y (n 1,413), 45-54 y (n = 1,384), and 55-79 y (n = 834). MS components, brachial-ankle PWV (baPWV), high-sensitivity C-reactive protein (hs-CRP), and oxidative stress markers were measured.
   Results: There were age-related increases in MS, body mass index (BMI), waist circumference, systolic blood pressure (SBP), diastolic BP (DBP), triglycerides, glucose, hs-CRP, oxidized low-density lipoprotein (LDL), 8-epi-prostaglandin F-2 alpha (8-epi-PGF(2 alpha)), and baPWV. BaPWV was significantly associated with sex and elevated BP in the 19-34 y group; with age, sex, BMI, elevated BP and triglycerides in the 35-44 y group; with age, sex, elevated BP, fasting glucose, hs-CRP and oxidized LDL in the 45-54 y group; and with age, BMI, elevated BP, fasting glucose and oxidized LDL in the 55-79 y group.
   Conclusions: Our results show that age-related increases in baPWV are associated with age-related changes in MS components, inflammatory markers, and oxidative stress. However, each of these factors has an age-specific, different impact on arterial stiffness. In particular, oxidative stress may be independently associated with arterial stiffness in individuals older than 45 y.
C1 [Kim, Minkyung; Kim, Minjoo; Lee, Jong Ho] Yonsei Univ, Res Ctr Silver Sci, Inst Symbiot Life TECH, Seoul, South Korea.
   [Yoo, Hye Jin; Lee, Seung Yeon; Lee, Jong Ho] Yonsei Univ, Coll Human Ecol, Dept Food & Nutr, Natl Leading Res Lab Clin Nutrigenet Nutrigen, Seoul, South Korea.
   [Yoo, Hye Jin; Lee, Seung Yeon; Lee, Jong Ho] Yonsei Univ, Coll Human Ecol, Brain Korea PLUS Project 21, Dept Food & Nutr, Seoul, South Korea.
   [Lee, Sang-Hyun] Ilsan Hosp, Natl Hlth Insurance Corp, Dept Family Practice, Goyang, South Korea.
C3 Yonsei University; Yonsei University; Yonsei University; NHIS Ilsan
   Hospital
RP Lee, JH (corresponding author), Yonsei Univ, Coll Human Ecol, Dept Food & Nutr, 50 Yonsei Ro, Seoul 03722, South Korea.
EM jhleeb@yonsei.ac.kr
RI Lee, Sang-Hyun/ABR-3363-2022; Kim, Minjoo/AEN-5516-2022
FU Bio-Synergy Research Project [NRF-2012 M3A9C4048762]; Mid-career
   Researcher Program of the Ministry of Science, ICT and Future Planning
   through the National Research Foundation of the Republic of Korea
   [NRF-2016R1A2B4011662]
FX This study was funded by the Bio-Synergy Research Project (NRF-2012
   M3A9C4048762) and the Mid-career Researcher Program
   (NRF-2016R1A2B4011662) of the Ministry of Science, ICT and Future
   Planning through the National Research Foundation of the Republic of
   Korea.
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NR 25
TC 28
Z9 30
U1 0
U2 2
PU JAPAN ATHEROSCLEROSIS SOC
PI TOKYO
PA NICHINAI-KAIKAN B1, 3-28-8 HONGO BUNKYO-KU, TOKYO, 113-0033, JAPAN
SN 1340-3478
EI 1880-3873
J9 J ATHEROSCLER THROMB
JI J. Atheroscler. Thromb.
PY 2018
VL 25
IS 2
BP 178
EP 185
DI 10.5551/jat.39388
PG 8
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA FV3ZR
UT WOS:000424513600010
PM 28740031
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Flore, P
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   van de Vliet, P
   Faure, P
AF Flore, Patrice
   Bricout, Veronique-A
   van Biesen, Debbie
   Guinot, Michel
   Laporte, Francois
   Pepin, Jean-Louis
   Eberhard, Yves
   Favre-Juvin, Anne
   Wuyam, Bernard
   van de Vliet, Peter
   Faure, Patrice
TI Oxidative stress and metabolism at rest and during exercise in persons
   with Down syndrome
SO EUROPEAN JOURNAL OF CARDIOVASCULAR PREVENTION & REHABILITATION
LA English
DT Article
DE Down syndrome; fat oxidation; insulin sensitivity; metabolic syndrome;
   muscular exercise; oxidative stress
ID OBSTRUCTIVE SLEEP-APNEA; PHYSICAL-ACTIVITY; MENTAL-RETARDATION;
   BODY-FAT; INSULIN SENSITIVITY; DISEASE; ADOLESCENTS; GLUTATHIONE;
   INTENSITY; CHILDREN
AB Background Down syndrome (DS) is a risk factor for metabolic syndrome and cardiovascular disease. The greater oxidative stress described in DS can increase this risk owing to its potential deleterious effects on insulin sensitivity. We hypothesized that metabolic syndrome or its markers, at rest and during exercise, are more pronounced in young adults with DS.
   Design The study design is that of a controlled study.
   Methods Thirteen physically active young adults with DS, after overnight polysomnography, plasma-lipid profile, and insulin-resistance [Homeostasis Model Assessment Insulin Resistance (HOMA-IR)] assessments, underwent a sub-maximal progressive treadmill exercise (10 min at 30 and 50%, and 20 min at 75% of V-O2max), allowing for maximal fat-oxidation rate and blood-oxidative stress determinations. They were compared with 15 healthy control participants (C).
   Results V-O2max DS participants was lower than that of C (60.8 +/- 2.4 versus 44.4 +/- 3.3 ml/kg/min; P<0.001) but was close to the predicted value (95 +/- 6%). In DS participants, as expected, oxidative stress was greater than in C (+ 15%; P<0.001) at rest and all through the exercise protocol. Although a greater fat mass (DS: 19.9 +/- 1.3%; C: 13.5 +/- 0.9%; P<0.001), and a lower insulin sensitivity (HOMA-IR in DS: 1.09 +/- 0.16; in C: 0.64 +/- 0.13; P<0.05) was observed for DS participants, a metabolic syndrome could not be shown. Maximal fat-oxidation rate was lower in DS participants (394.2 +/- 69.9 versus 486.1 +/- 134.8 mg/min in C; P<0.01), but it was in the normal range.
   Conclusion Despite greater oxidative stress and lower insulin sensitivity, the DS group involved in our study did not display clear metabolic abnormalities. The young age and lifestyle of this group might, partially, have accounted for this apparently healthy metabolic status.
C1 [Flore, Patrice; Bricout, Veronique-A; van Biesen, Debbie; Wuyam, Bernard] Univ Grenoble 1, UFRAPS & UFR Sante, IFR 1,Res Exercise & Hlth Lab, S Hosp,Grenoble Univ Hosp, F-38041 Grenoble, France.
   [Flore, Patrice; Bricout, Veronique-A; Guinot, Michel; Favre-Juvin, Anne; Wuyam, Bernard] Grenoble Univ Hosp, Med Unit Sport Med Traumatol, Grenoble, France.
   [Flore, Patrice; Bricout, Veronique-A; Guinot, Michel; Favre-Juvin, Anne; Wuyam, Bernard] S Hosp, Physiol Reeducat Ctr, Clin Res Exercise Physiol Sleep & Exercise Clin, Grenoble, France.
   [Laporte, Francois; Faure, Patrice] Grenoble Univ Hosp, Dept Integrat Biol, Grenoble, France.
   [Pepin, Jean-Louis] Grenoble Univ Hosp, Sleep Lab, Physiol Sleep & Exercise Clin, Physiol Reeducat Ctr, Grenoble, France.
   [Pepin, Jean-Louis; Faure, Patrice] Univ Grenoble 1, INSERM, ERI17, IFR 1,Lab HP2, F-38041 Grenoble, France.
   [Eberhard, Yves] Univ Grenoble 1, INSERM E221, Fundamental & Appl Biol Lab, IFR 1, F-38041 Grenoble, France.
   [van Biesen, Debbie; van de Vliet, Peter] Katholieke Univ Leuven, Dept Rehabil Sci, Louvain, Belgium.
C3 Communaute Universite Grenoble Alpes; Universite Grenoble Alpes (UGA);
   CHU Grenoble Alpes; Communaute Universite Grenoble Alpes; Universite
   Grenoble Alpes (UGA); CHU Grenoble Alpes; CHU Grenoble Alpes; Communaute
   Universite Grenoble Alpes; Universite Grenoble Alpes (UGA); CHU Grenoble
   Alpes; Communaute Universite Grenoble Alpes; Universite Grenoble Alpes
   (UGA); CHU Grenoble Alpes; Communaute Universite Grenoble Alpes;
   Universite Grenoble Alpes (UGA); Institut National de la Sante et de la
   Recherche Medicale (Inserm); Communaute Universite Grenoble Alpes;
   Universite Grenoble Alpes (UGA); Institut National de la Sante et de la
   Recherche Medicale (Inserm); KU Leuven
RP Flore, P (corresponding author), Hop Sud, BP 185, F-38042 Grenoble 09, France.
EM PFlore@chu-grenoble.fr
RI Guinot, Michel/M-7128-2014; PEPIN, Jean-Louis/M-6549-2014; FLORE,
   Patrice/AAC-4197-2019; BRICOUT, Veronique/M-7688-2014
OI Pepin, Jean Louis/0000-0003-3832-2358; FLORE,
   Patrice/0000-0002-6907-7853; Van Biesen, Debbie/0000-0002-2754-4679;
   BRICOUT, Veronique/0000-0003-3499-7016
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NR 52
TC 31
Z9 34
U1 0
U2 10
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1741-8267
EI 1741-8275
J9 EUR J CARDIOV PREV R
JI Eur. J. Cardiovasc. Prev. Rehabil.
PD FEB
PY 2008
VL 15
IS 1
BP 35
EP 42
DI 10.1097/HJR.0b013e3282f2bff3
PG 8
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 277OO
UT WOS:000254223600006
PM 18277183
OA Bronze
DA 2025-06-11
ER

PT J
AU Vávrová, L
   Kodydková, J
   Zeman, M
   Dusejovská, M
   Macásek, J
   Stanková, B
   Tvrzická, E
   Zák, A
AF Vavrova, Lucie
   Kodydkova, Jana
   Zeman, Miroslav
   Dusejovska, Magdalena
   Macasek, Jaroslav
   Stankova, Barbora
   Tvrzicka, Eva
   Zak, Ales
TI Altered Activities of Antioxidant Enzymes in Patients with Metabolic
   Syndrome
SO OBESITY FACTS
LA English
DT Article
DE Metabolic syndrome; Antioxidant enzymes; Reduced glutathione; Conjugated
   dienes
ID INCREASED OXIDATIVE STRESS; INSULIN-RESISTANCE; FAT OVERLOAD;
   LIPOPROTEIN; HYPERTRIGLYCERIDEMIA; PARAOXONASE-1; DEFENSE; PLASMA
AB Objective: In the pathogenesis of the metabolic syndrome (MetS), an increase of oxidative stress could play an important role which is closely linked with insulin resistance, endothelial dysfunction, and chronic inflammation. The aim of our study was to assess several parameters of the antioxidant status in MetS. Methods: 40 subjects with MetS and 40 age- and sex-matched volunteers without MetS were examined for activities of superoxide dismutase (CuZnSOD), catalase (CAT), glutathione peroxidase 1 (GPX1), glutathione reductase (GR), para-oxonase1 (PON1), concentrations of reduced glutathione (GSH), and conjugated dienes in low-density lipoprotein (CD-LDL). Results: Subjects with MetS had higher activities of CuZnSOD (p < 0.05) and GR (p < 0.001), higher concentrations of CD-LDL (p < 0.001), lower activities of CAT (p < 0.05) and PON1 (p < 0.05), and lower concentrations of GSH (p < 0.05), as compared with controls. Activity of GPX1 was not significantly changed. Conclusions: Our results implicated an increased oxidative stress in MetS and a decreased antioxidative defense that correlated with some laboratory (triglycerides, high-density lipoprotein cholesterol (HDL-C)) and clinical (waist circumference, blood pressure) components of MetS. Copyright (C) 2013 S. Karger GmbH, Freiburg
C1 [Vavrova, Lucie] Charles Univ Prague, Fac Med 1, Dept Internal Med 4, Prague 12801 2, Czech Republic.
   [Vavrova, Lucie] Gen Teaching Hosp, Prague 12801 2, Czech Republic.
C3 Charles University Prague; General University Hospital Prague
RP Vávrová, L (corresponding author), Charles Univ Prague, Fac Med 1, Dept Internal Med 4, U Nemocnice 2, Prague 12801 2, Czech Republic.
EM vavrova3@seznam.cz
RI Vavrova, Lucie/D-7030-2017; Tvrzicka, Eva/Q-6300-2016; Stankova,
   Barbora/L-7933-2016; Rychlikova, Jana/A-2531-2015; Macasek,
   Jaroslav/G-8337-2016; Dusejovska, Magdalena/R-1051-2016; Zeman,
   Miroslav/J-5281-2016; Zak, Ales/G-8318-2016
OI Tvrzicka, Eva/0000-0003-0794-8454; Stankova,
   Barbora/0000-0002-6184-4878; Rychlikova, Jana/0000-0002-6961-5260;
   Macasek, Jaroslav/0000-0002-8009-8970; Dusejovska,
   Magdalena/0000-0003-3599-006X; Zeman, Miroslav/0000-0001-5338-603X; Zak,
   Ales/0000-0002-1698-6068
FU Charles University in Prague, First Faculty of Medicine
   [PRVOUK-P25/LF1/2]; Ministry of Health of the Czech Republic [IGA
   NS9769-4]
FX This work was supported by by the Research Project of Charles University
   in Prague, First Faculty of Medicine - PRVOUK-P25/LF1/2, and by the
   grant IGA NS9769-4 of the Ministry of Health of the Czech Republic.
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NR 39
TC 36
Z9 37
U1 0
U2 14
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1662-4025
EI 1662-4033
J9 OBESITY FACTS
JI Obes. Facts
PD MAR
PY 2013
VL 6
IS 1
BP 39
EP 47
DI 10.1159/000348569
PG 9
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 101KB
UT WOS:000315772800005
PM 23429207
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Zhou, J
   Massey, S
   Story, D
   Li, LX
AF Zhou, Joseph
   Massey, Scott
   Story, Darren
   Li, Lixin
TI Metformin: An Old Drug with New Applications
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE metformin; NAFLD; inflammation; metabolic syndrome; ER stress
ID FATTY LIVER-DISEASE; INSULIN-RESISTANCE; APOLIPOPROTEIN A5; OXIDATIVE
   STRESS; GLUCOSE CONTROL; ADIPOSE-TISSUE; PROTEIN-KINASE; TYPE-2;
   INFLAMMATION; MICE
AB Metformin is a biguanide drug that has been used to treat type 2 diabetes mellitus for more than 60 years. The United Kingdom Prospective Diabetic Study (UKPDS) has shown metformin to improve mortality rates in diabetes patients, and recent studies suggest metformin has additional effects in treating cancer, obesity, nonalcoholic fatty liver disease (NAFLD), polycystic ovary syndrome (PCOS), and metabolic syndrome. Metformin has also been shown to alleviate weight gain associated with antipsychotic medication. Metformin has recently been extensively studied and emerging evidence suggests metformin decreases hepatocyte triglyceride accumulation in NAFLD and prevents liver tumorigenesis. Interestingly, studies have also shown metformin reduces visceral fat, suppresses white-adipose-tissue (WAT) extracellular matrix remodeling, and inhibits obesity-induced inflammation. However, clinical evidence for using metformin to treat NAFLD, cancer, metabolic syndrome, or to prevent hepatocellular carcinoma in NAFLD patients is lacking. This review therefore addresses the potential beneficial effects of metformin on NAFLD, its role in protecting against cardiac ischemia-reperfusion (I/R) injury, atherosclerosis, glucotoxicity, and lipotoxicity induced oxidative and ER stress in pancreatic -cell dysfunction, as well as its underlying molecular mechanisms of action.
C1 [Zhou, Joseph] Cent Michigan Univ, Coll Med, Mt Pleasant, MI 48859 USA.
   [Massey, Scott; Li, Lixin] Cent Michigan Univ, Phys Assistant Program, Coll Hlth Profess, Mt Pleasant, MI 48859 USA.
   [Story, Darren] Cent Michigan Univ, Program Neurosci, Mt Pleasant, MI 48859 USA.
C3 Central Michigan University; Central Michigan University; Central
   Michigan University
RP Li, LX (corresponding author), Cent Michigan Univ, Phys Assistant Program, Coll Hlth Profess, Mt Pleasant, MI 48859 USA.
EM zhou1jy@cmich.edu; masse2sl@cmich.edu; story1dt@gmail.com;
   li6l@cmich.edu
RI LI, LIXIN/KFS-0074-2024; Story, Darren/JBJ-2063-2023
OI Story, Darren/0000-0002-0902-5728
FU College of Health Profession, Central Michigan University
FX L.L. is supported by a faculty start-up fund from College of Health
   Profession, Central Michigan University.
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NR 77
TC 174
Z9 188
U1 5
U2 75
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD OCT
PY 2018
VL 19
IS 10
AR 2863
DI 10.3390/ijms19102863
PG 15
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA GY9HB
UT WOS:000448951000018
PM 30241400
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT S
AU Valsamakis, G
   Kanaka-Gantenbein, C
   Malamitsi-Puchner, A
   Mastorakos, G
AF Valsamakis, George
   Kanaka-Gantenbein, Christina
   Malamitsi-Puchner, Ariadne
   Mastorakos, George
BE Creatsas, G
   Mastorakos, G
   Chrousos, GP
TI Causes of intrauterine growth restriction and the postnatal development
   of the metabolic syndrome
SO WOMEN'S HEALTH AND DISEASE: GYNECOLOGIC, ENDOCRINE, AND REPRODUCTIVE
   ISSUES
SE Annals of the New York Academy of Sciences
LA English
DT Article; Proceedings Paper
CT 6th Athens Congress on Womens Health and Disease
CY SEP 23-25, 2005
CL Athens, GREECE
SP Athens Univ, Med Sch, Int Menopause Soc, European Menopause & Andropause Soc, Int Federat Gynecol & Obstet
DE IUGR; SGA; fetal origin; metabolic syndrome; cardiovascular disease
ID 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-2; FOR-GESTATIONAL-AGE;
   LOW-BIRTH-WEIGHT; FETAL-GROWTH; CARDIOVASCULAR-DISEASE;
   INSULIN-RESISTANCE; ADIPONECTIN LEVELS; DIABETES-MELLITUS;
   SKELETAL-MUSCLE; HUMAN-PREGNANCY
AB The term intrauterine growth restriction (IUGR) is assigned to newborns with a birth weight and/or birth length below the 10th percentile for their gestational age and whose abdominal circumference is below the 2.5th percentile with pathologic restriction of fetal growth. IUGR is usually due to maternal, fetal, or placental factors. However, many IUGR cases have unknown underlying cause. Recent studies focus on new factors that can influence fetal development and birth outcome like the timing and the type of fetal nutrition, maternal psychosocial stress and personality variables, I I P-hydroxysteroid dehydrogenase type 2 placental activity, the activity of the neuroendocrine system that mediates the effects of psychosocial stress, and the role of proinflammatory cytokines and of oxidative stress. Data have shown that IUGR is associated with a late life increased prevalence of metabolic syndrome, a condition associating obesity with hypertension, type 2 diabetes mellitus (DM2), and cardiovascular disease. Recent data demonstrated that the diabetes-associated mortality appears to be disproportionately concentrated among individuals of abnormal birth weight.
C1 Univ Athens, Sch Med, Aretaieion Hosp, Dept Obstet & Gynaecol 2,Endocrine Unit, GR-11527 Athens, Greece.
   Univ Athens, Sch Med, Aretaieion Hosp, Dept Obstet & Gynaecol 2,Neonatal Div, GR-11527 Athens, Greece.
   Univ Athens, Sch Med, Aghia Sofia Childrens Hosp, Dept Paediat 1,Unit Endocrinol Diabet & Metab, GR-11527 Athens, Greece.
C3 Athens Medical School; National & Kapodistrian University of Athens;
   National & Kapodistrian University of Athens; Athens Medical School;
   National & Kapodistrian University of Athens; Athens Medical School; The
   Aghia Sophia Children's Hospital
RP Valsamakis, G (corresponding author), Leoforos Pendelis 37A, Athens 15235, Greece.
EM geodimval@hotmail.com
RI Kanaka-Gantenbein, Christina/AAP-3697-2020
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NR 49
TC 118
Z9 140
U1 2
U2 18
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN STREET, MALDEN 02148, MA USA
SN 0077-8923
BN 978-1-57331-621-7
J9 ANN NY ACAD SCI
JI Ann.NY Acad.Sci.
PY 2006
VL 1092
BP 138
EP 147
DI 10.1196/annals.1365.012
PG 10
WC Endocrinology & Metabolism; Multidisciplinary Sciences; Obstetrics &
   Gynecology
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Science & Technology - Other Topics;
   Obstetrics & Gynecology
GA BFZ47
UT WOS:000245624300011
PM 17308140
DA 2025-06-11
ER

PT J
AU Soltysik, BK
   Karolczak, K
   Watala, C
   Kostka, T
AF Soltysik, Bartlomiej K.
   Karolczak, Kamil
   Watala, Cezary
   Kostka, Tomasz
TI The Association of Oxidative and Antioxidant Potential with
   Cardiometabolic Risk Profile in the Group of 60-to 65-Year-Old Seniors
   from Central Poland
SO ANTIOXIDANTS
LA English
DT Article
DE oxidative stress; antioxidant status; cardiovascular risk; elderly
ID SUPEROXIDE ANION GENERATION; VON-WILLEBRAND-FACTOR; MIDDLE-AGED MEN;
   NITRIC-OXIDE; GLUTATHIONE-PEROXIDASE; LIPID-PEROXIDATION; METABOLIC
   SYNDROME; URIC-ACID; VITAMIN-E; STRESS
AB Pathogenesis of cardiovascular diseases is caused by, inter alia, oxidative stress. On the other hand, cardiovascular risk factors may cause redox imbalance. The pathological pathways between those components are to be determined. In the group comprised of 300 sex-matched subjects, we evaluated a number of cardiovascular risk factors: blood pressure, body mass, lipids, glucose, homocysteine, uric acid, von Willebrand factor (vWF), VCAM-1 and ICAM-1. The presence of cardiovascular diseases and drugs for their treatment were examined. Secondly, we assessed total antioxidative status (TAS), total oxidative status (TOS) and other markers of oxidative stress. TAS was inversely related to LDL cholesterol. TOS was positively associated with BMI and female sex, but negatively associated with the use of angiotensin II receptor antagonists. Plasma lipid peroxides concentration was positively related to ICAM-1 and presence of stroke, whereas platelet lipid peroxides were positively associated with vWF. Platelets proteins thiol groups were in a positive relationship with vWF, but in a negative relationship with uric acid and diagnosed lipid disorders. Both free thiol and amino groups were positively associated with plasma glucose. Platelets free amino groups were related to platelets count. Superoxide generation by blood platelets (both with and without homocysteine) was positively connected to glucose level. Among women, oxidative markers appear to be more related to glucose level, whereas among men they are related to body mass indices. TAS, TOS and oxidative markers are largely related to modifiable cardiovascular risk factors such as body mass, and intake of drugs such as angiotensin II receptor blockers. Plasma and platelet oxidation markers appear to be especially associated with glucose concentration. The presented analyses unanimously indicate strong connections between cardiovascular risk factors and redox potential and specify how cardiometabolic interventions may counter-balance oxidative stress.
C1 [Soltysik, Bartlomiej K.; Kostka, Tomasz] Med Univ Lodz, Dept Geriatr, PL-90419 Lodz, Poland.
   [Karolczak, Kamil; Watala, Cezary] Med Univ Lodz, Dept Haemostat Disorders, PL-90419 Lodz, Poland.
C3 Medical University Lodz; Medical University Lodz
RP Soltysik, BK (corresponding author), Med Univ Lodz, Dept Geriatr, PL-90419 Lodz, Poland.
EM bartlomiej.soltysik@office365.umed.pl;
   kamil.karolczak@office365.umed.pl; cezary.watala@office365.umed.pl;
   tomasz.kostka@office365.umed.pl
RI Watala, Cezary/ABF-4863-2020; Karolczak, Kamil/HDM-6855-2022; Soltysik,
   Bartlomiej K./S-9839-2016
OI Soltysik, Bartlomiej K./0000-0002-1382-3757; Kostka,
   Tomasz/0000-0003-0437-650X
FU Central Institute for Labour Protection-National Research Institute
   project [KBNSR/N/I/427/2014]; Medical University of Lodz, Poland
   [503/6-020-01/503-61-001, 503/6-077-01/503-61-001]
FX The authors were partly supported by the Central Institute for Labour
   Protection-National Research Institute project (KBNSR/N/I/427/2014) and
   received grants founded by Medical University of Lodz, Poland
   (503/6-020-01/503-61-001 and 503/6-077-01/503-61-001).
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NR 64
TC 7
Z9 7
U1 0
U2 3
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD JUN
PY 2022
VL 11
IS 6
AR 1065
DI 10.3390/antiox11061065
PG 16
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA 2M4SC
UT WOS:000817690100001
PM 35739962
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Gryzinski, GM
   Bernie, HL
AF Gryzinski, Gustavo M.
   Bernie, Helen L.
TI Testosterone deficiency and the aging male
SO INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH
LA English
DT Review
ID LATE-ONSET HYPOGONADISM; HORMONE-BINDING GLOBULIN; LOW SERUM
   TESTOSTERONE; SEX STEROID-HORMONES; CIGARETTE-SMOKING; ENDOGENOUS
   TESTOSTERONE; METABOLIC SYNDROME; PULSE FREQUENCY; BLOOD-PRESSURE; MEN
AB Testosterone deficiency (TD), also known as male hypogonadism, is a complex syndrome encompassing physical, biochemical, and social aspects that increasingly affects the aging population. TD has been analyzed over recent decades, with an enhanced focus on etiologies relating to aging males. There is debate whether testosterone decline leading to hypogonadism is directly and primarily related to age-specific processes or if it is the subsequent result of accumulating comorbidities throughout a lifetime. Several studies have been done to further characterize this distinction. Chronic comorbidities that have commonly been associated with TD include hypertension (HTN), cardiovascular disease (CVD), diabetes mellitus (DM), obesity, metabolic syndrome (MetS), chronic kidney disease (CKD), and tobacco use. Although clear associations between hypogonadism and aging have been biochemically demonstrated, many large studies have illustrated the concomitant effects of highly prevalent chronic diseases and social behaviors in aging men. Given the significant impact of hypogonadism on the physical and mental health of men, this paper aims to delve into these studies and further define the complex relationship of testosterone deficiency in the aging male.
C1 [Gryzinski, Gustavo M.] Indiana Univ, Sch Med, Indianapolis, IN USA.
   [Bernie, Helen L.] Indiana Univ, Dept Urol, Indianapolis, IN 46204 USA.
C3 Indiana University System; Indiana University Indianapolis; Indiana
   University System; Indiana University Indianapolis
RP Bernie, HL (corresponding author), Indiana Univ, Dept Urol, Indianapolis, IN 46204 USA.
EM Hbernie@IUHealth.org
OI Bernie, Helen L./0000-0002-3665-6074; Gryzinski,
   Gustavo/0000-0001-6952-8207
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NR 63
TC 6
Z9 7
U1 0
U2 4
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0955-9930
EI 1476-5489
J9 INT J IMPOT RES
JI Int. J. Impot. Res.
PD NOV
PY 2022
VL 34
IS 7
BP 630
EP 634
DI 10.1038/s41443-022-00555-7
EA APR 2022
PG 5
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 6H2ZA
UT WOS:000779223400001
PM 35393533
DA 2025-06-11
ER

PT J
AU Bhargava, P
   Lee, CH
AF Bhargava, Prerna
   Lee, Chih-Hao
TI Role and function of macrophages in the metabolic syndrome
SO BIOCHEMICAL JOURNAL
LA English
DT Review
DE inflammatory signalling; insulin resistance; macrophage activation;
   metabolic disease; metabolic syndrome; white adipose tissue inflammation
ID INDUCED INSULIN-RESISTANCE; ENDOPLASMIC-RETICULUM STRESS; NF-KAPPA-B;
   ADIPOSE-TISSUE INFLAMMATION; TYPE-2 DIABETES-MELLITUS; ADVANCED
   ATHEROSCLEROTIC LESIONS; OBESITY-INDUCED INFLAMMATION; DIET-INDUCED
   INFLAMMATION; NECROSIS-FACTOR-ALPHA; REGULATORY T-CELLS
AB Macrophages are key innate immune effector cells best known for their role as professional phagocytes, which also include neutrophils and dendritic cells. Recent evidence indicates that Macrophages are also key players in Metabolic homoeostasis. Macrophages can be found in many tissues, where they respond to metabolic cues and produce pro- and/or anti-inflammatory mediators to modulate metabolite programmes. Certain metabolites, such as fatty acids, ceramides and cholesterol crystals, elicit inflammatory responses through pathogen-sensing signalling pathways, implicating a maladaptation of macrophages and the innate immune system to elevated metabolic stress associated with overnutrition in modern societies. The outcome of this maladaptation is a feedforward inflammatory response leading to a state of unresolved inflammation and a collection of metabolic pathologies, including insulin resistance, fatty liver, atherosclerosis and dyslipidaemia. The present review summarizes what is known about the contributions of macrophages to metabolic diseases and the signalling pathways that are involved in metabolic stress-induced macrophage activation. Understanding the role of macrophages in these processes will help us to develop therapies against detrimental effects of the metabolic syndrome.
C1 [Bhargava, Prerna; Lee, Chih-Hao] Harvard Univ, Sch Publ Hlth, Dept Genet & Complex Dis, Div Biol Sci,Dept Nutr, Boston, MA 02115 USA.
C3 Harvard University; Harvard T.H. Chan School of Public Health
RP Lee, CH (corresponding author), Harvard Univ, Sch Publ Hlth, Dept Genet & Complex Dis, Div Biol Sci,Dept Nutr, 665 Huntington Ave, Boston, MA 02115 USA.
EM clee@hsph.harvard.edu
FU National Institute of Diabetes and Digestive and Kidney Disease (NIDDK)
   [T90DK070078]; American Diabetes Association; American Heart
   Association; National Institutes of Health [R01DK075046]
FX P.B. is supported by the National Institute of Diabetes and Digestive
   and Kidney Disease (NIDDK) [training grant number T90DK070078]. C.H.L.
   is supported by the American Diabetes Association, the American Heart
   Association and the National Institutes of Health [grant number
   R01DK075046].
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NR 176
TC 97
Z9 110
U1 0
U2 26
PU PORTLAND PRESS LTD
PI LONDON
PA CHARLES DARWIN HOUSE, 12 ROGER STREET, LONDON WC1N 2JU, ENGLAND
SN 0264-6021
EI 1470-8728
J9 BIOCHEM J
JI Biochem. J.
PD MAR 1
PY 2012
VL 442
BP 253
EP 262
DI 10.1042/BJ20111708
PN 2
PG 10
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 902LA
UT WOS:000301038400002
PM 22329799
DA 2025-06-11
ER

PT J
AU Lespérance, F
   Frasure-Smith, N
   Théroux, P
   Irwin, M
AF Lespérance, F
   Frasure-Smith, N
   Théroux, P
   Irwin, M
TI The association between major depression and levels of soluble
   intercellular adhesion molecule 1, interleukin-6, and C-reactive protein
   in patients with recent acute coronary syndromes
SO AMERICAN JOURNAL OF PSYCHIATRY
LA English
DT Article; Proceedings Paper
CT 60th Annual Meeting of the American-Psychosomatic-Society
CY MAR 13-16, 2002
CL BARCELONA, SPAIN
SP Amer Psychosomat Soc
ID FUTURE MYOCARDIAL-INFARCTION; CARDIOVASCULAR-DISEASE;
   PLASMA-CONCENTRATION; HEART-DISEASE; RISK; INFLAMMATION; STRESS;
   ACTIVATION; EXPRESSION; CYTOKINES
AB Objective: This study was conducted to determine whether or not depression is associated with higher levels of inflammatory markers in patients recovering from acute coronary syndromes.
   Method: Plasma levels of soluble intercellular adhesion molecule 1 (sICAY-1) and interleukin-6 (IL-6) and the serum level of C-reactive protein were measured in 481 patients 2 months after hospitalization for acute coronary syndromes. Diagnosis of major depression was based on the Structured Clinical Interview for DSM-IV.
   Results: Depressed patients showed significantly higher sICAM-1 levels, a difference that remained significant after adjustment for potential confounders (gender, smoking, presence of metabolic syndrome). Although there was no significant association between depression and IL-6, there was an interaction between depression and statin therapy for levels of C-reactive protein. Depressed patients not taking statins had markedly higher C-reactive protein levels than did nondepressed patients. There was no relationship with depression in those receiving statins.
   Conclusions. These results suggest chronic endothelial activation among depressed patients after acute coronary syndromes. Further research is needed to determine whether or not higher levels of sICAM-1 may identify a subgroup of depressed patients at particularly high risk for cardiac events among patients with established coronary artery disease or among those without previous coronary artery disease.
C1 CHU Montreal, Dept Psychiat, Montreal, PQ H2W 1T8, Canada.
   Montreal Heart Inst, Res Ctr, Montreal, PQ H1T 1C8, Canada.
   McGill Univ, Fac Med, Dept Psychiat, Montreal, PQ H3A 2T5, Canada.
   Hop Sacre Coeur, Dept Med, Div Cardiol, Montreal, PQ H4J 1C5, Canada.
   Univ Calif Los Angeles, Inst Neuropsychiat, Cousins Ctr Psychoneuroimmunol, Los Angeles, CA 90024 USA.
C3 Universite de Montreal; Universite de Montreal; McGill University;
   Universite de Montreal; University of California System; University of
   California Los Angeles
RP CHU Montreal, Dept Psychiat, 3850 St Urbain, Montreal, PQ H2W 1T8, Canada.
EM francois.lesperance@umontreal.ca
RI Lesperance, Francois/C-4716-2015; Irwin, Michael/H-4870-2013
OI Irwin, Michael/0000-0002-1502-8431
FU NIMH NIH HHS [MH-55253] Funding Source: Medline
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NR 35
TC 225
Z9 268
U1 0
U2 11
PU AMER PSYCHIATRIC PUBLISHING, INC
PI WASHINGTON
PA 800 MAINE AVE SW, SUITE 900, WASHINGTON, DC 20024 USA
SN 0002-953X
EI 1535-7228
J9 AM J PSYCHIAT
JI Am. J. Psychiat.
PD FEB
PY 2004
VL 161
IS 2
BP 271
EP 277
DI 10.1176/appi.ajp.161.2.271
PG 7
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI); Conference Proceedings Citation Index - Science (CPCI-S); Conference Proceedings Citation Index - Social Science &amp; Humanities (CPCI-SSH)
SC Psychiatry
GA 818WT
UT WOS:000221275900013
PM 14754776
DA 2025-06-11
ER

PT J
AU Fang, CC
   Wu, WJ
   Gu, XJ
   Dai, SS
   Zhou, Q
   Deng, HH
   Shen, FX
   Chen, JJ
AF Fang, Chenchen
   Wu, Wenjun
   Gu, Xuejiang
   Dai, Shanshan
   Zhou, Qi
   Deng, Huihui
   Shen, Feixia
   Chen, Junjie
TI Association of serum copper, zinc and selenium levels with risk of
   metabolic syndrome: A nested case-control study of middle-aged and older
   Chinese adults
SO JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
LA English
DT Article
DE Copper; Zinc; Selenium; Metabolic syndrome; Component
ID IMPAIRED FASTING GLUCOSE; OXIDATIVE STRESS; ANTIOXIDANT SUPPLEMENTATION;
   DIABETIC INDIVIDUALS; INSULIN-RESISTANCE; PLASMA SELENIUM;
   TRACE-ELEMENTS; LIPID PROFILE; VITAMIN-E; CANCERS
AB Trace elements, such as copper, zinc and selenium, have been linked to the development of metabolic syndrome. However, previous studies concerning these trace elements in association with metabolic syndrome have presented conflicting results in different countries. The aim of this study was to analyse the association between serum copper, zinc and selenium concentrations and the risk of metabolic syndrome among middle-aged and older Chinese adults. We performed a nested case-control study that included 349 individuals who developed metabolic syndrome (125 males and 224 females) during a 3-year follow-up and 349 controls matched by baseline age (+/-1 years), sex and area. Serum trace element concentrations were measured using atomic absorption spectrometry. The median serum selenium levels in males and females in the metabolic syndrome group were 82.2 (13.4) pg/L and 82.6 (11.1) pg/L, respectively, which were significantly higher than the serum selenium levels in the control group (p = 0.001 and p < 0.001). After adjusting for potential confounders, the odds ratios of risk for metabolic syndrome in the highest tertile of serum selenium levels were 2.72 [95% confidence interval (CI) 1.43-5.20; p for trend 0.002] for males and 5.30 (95% CI 3.31-8.74; p for trend < 0.001) for females, respectively, compared with the lowest tertile. In addition, serum selenium levels were positively correlated with postprandial plasma glucose in both genders (for males: odds ratio 2.42; 95% CI 1.27-4.61; for females: odds ratio 2.11; 95% CI 1.32-3.37) and negatively associated with high-density lipoprotein in only females (odds ratio 3.21; 95% CI 1.75-5.91). These results suggest that higher levels of serum selenium might be an independent risk factor for metabolic syndrome, especially in relation to elevated postprandial plasma glucose and reduced high-density lipoprotein levels. However, we failed to demonstrate an association between copper or zinc status and metabolic syndrome or its components.
C1 [Fang, Chenchen; Dai, Shanshan] Wenzhou Med Univ, Affiliated Hosp 1, Dept Emergency, Wenzhou, Peoples R China.
   [Wu, Wenjun; Gu, Xuejiang; Zhou, Qi; Deng, Huihui; Shen, Feixia] Wenzhou Med Univ, Affiliated Hosp 1, Dept Endocrine & Metab Dis, Wenzhou, Peoples R China.
   [Chen, Junjie] Wenzhou Med Univ, Affiliated Hosp 1, Dept Resp & Crit Care Med, Wenzhou, Peoples R China.
C3 Wenzhou Medical University; Wenzhou Medical University; Wenzhou Medical
   University
RP Shen, FX (corresponding author), Wenzhou Med Univ, Affiliated Hosp 1, Dept Endocrine & Metab Dis, Wenzhou, Peoples R China.; Chen, JJ (corresponding author), Wenzhou Med Univ, Affiliated Hosp 1, Dept Resp & Crit Care Med, Wenzhou, Peoples R China.
EM sfx301@163.com; jiestory414@163.com
RI chen, junjie/KYP-8763-2024; wenjun, wu/ABI-4150-2020
FU Chinese Society of Endocrinology; National Clinical Research Centre for
   Metabolic Diseases and Science and Technology Program project funds of
   Wenzhou [Y20170286]
FX This work was supported by grants from the Chinese Society of
   Endocrinology and the National Clinical Research Centre for Metabolic
   Diseases and Science and Technology Program project funds of Wenzhou
   (Grant Number: Y20170286)
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NR 48
TC 38
Z9 42
U1 0
U2 12
PU ELSEVIER GMBH
PI MUNICH
PA HACKERBRUCKE 6, 80335 MUNICH, GERMANY
SN 0946-672X
J9 J TRACE ELEM MED BIO
JI J. Trace Elem. Med. Biol.
PY 2019
VL 52
BP 209
EP 215
DI 10.1016/j.jtemb.2018.12.017
PG 7
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA HS6CO
UT WOS:000463958300028
PM 30732884
DA 2025-06-11
ER

PT J
AU Wang, CF
   Blough, E
   Arvapalli, R
   Dai, XN
   Triest, WE
   Leidy, JW
   Masannat, Y
   Wu, MZ
AF Wang, Cuifen
   Blough, Eric
   Arvapalli, Ravikumar
   Dai, Xiaoniu
   Triest, William E.
   Leidy, John W.
   Masannat, Yanal
   Wu, Miaozong
TI Acetaminophen attenuates glomerulosclerosis in obese Zucker rats via
   reactive oxygen species/p38MAPK signaling pathways
SO FREE RADICAL BIOLOGY AND MEDICINE
LA English
DT Article
DE Acetaminophen; Glomerulosclerosis; Obese Zucker rat; Human renal
   mesangial cell; Oxidative stress; p38MAPK; Glutathione synthetase; Free
   radicals
ID MONOCYTE CHEMOATTRACTANT PROTEIN-1; TISSUE GROWTH-FACTOR; INDUCED
   OXIDATIVE STRESS; METABOLIC SYNDROME; P38 MAPK; RENAL INJURY; INDUCED
   APOPTOSIS; KIDNEY; EXPRESSION; HYPERGLYCEMIA
AB Focal segmental glomerulosclerosis is a critical pathological lesion in metabolic syndrome-associated kidney disease that, if allowed to proceed unchecked, can lead to renal failure. However, the exact mechanisms underlying glomerulosclerosis remain unclear, and effective prevention strategies against glomerulosclerosis are currently limited. Herein, we demonstrate that chronic low-dose ingestion of acetaminophen (30 mg/kg/day for 6 months) attenuates proteinuria, glomerulosclerosis, podocyte injury, and inflammation in the obese Zucker rat model of metabolic syndrome. Moreover, acetaminophen treatment attenuated renal fibrosis and the expression of profibrotic factors (fibronectin, connective tissue growth factor, transforming growth factor beta), reduced inflammatory cell infiltration into the glomeruli, and decreased the expression of monocyte chemoattractant protein, glutathione (GSH). reductase, and nuclear factor erythroid 2-related factor 2, but increased the level of GSH synthetase in obese animals. Further in vivo and in vitro studies using human renal mesangial cells exposed to high glucose or hydrogen peroxide suggested that the renoprotective effects of acetaminophen are characterized by diminished renal oxidative stress and p38MAPK hyperphosphorylation. (C) 2015 Elsevier Inc. All rights reserved.
C1 [Wang, Cuifen; Blough, Eric; Arvapalli, Ravikumar; Wu, Miaozong] Marshall Univ, Ctr Diagnost Nanosyst, Huntington, WV 25755 USA.
   [Wang, Cuifen; Blough, Eric; Arvapalli, Ravikumar; Wu, Miaozong] Marshall Univ, Sch Pharm, Huntington, WV 25755 USA.
   [Wang, Cuifen; Dai, Xiaoniu] Southeast Univ, Nanjing, Jiangsu, Peoples R China.
   [Triest, William E.; Leidy, John W.] Huntington VA Med Ctr, Huntington, WV 25704 USA.
   [Masannat, Yanal; Wu, Miaozong] Joan C Edwards Sch Med, Dept Internal Med, Huntington, WV 25755 USA.
C3 Marshall University; Marshall University; Southeast University - China
RP Blough, E (corresponding author), Marshall Univ, Ctr Diagnost Nanosyst, Huntington, WV 25755 USA.
EM blough@marshall.edu; wum@marshall.edu
RI Wu, Miaozong/C-1344-2009
FU NASA EPSCoR [NNX13AN08A]; Department of Energy [DE-SC0005162];
   Huntington VA Medical Center; Joan C. Edwards School of Medicine
   Training Program in Endocrinology; U.S. Department of Energy (DOE)
   [DE-SC0005162] Funding Source: U.S. Department of Energy (DOE); NASA
   [467672, NNX13AN08A] Funding Source: Federal RePORTER
FX This work was supported by NASA EPSCoR NNX13AN08A (M.W.) and Department
   of Energy Grant DE-SC0005162 (E.B.). The authors acknowledge the support
   of the Huntington VA Medical Center and the Joan C. Edwards School of
   Medicine Training Program in Endocrinology for laboratory space and
   equipment.
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NR 50
TC 11
Z9 12
U1 0
U2 12
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0891-5849
EI 1873-4596
J9 FREE RADICAL BIO MED
JI Free Radic. Biol. Med.
PD APR
PY 2015
VL 81
BP 47
EP 57
DI 10.1016/j.freeradbiomed.2015.01.008
PG 11
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA CE9PL
UT WOS:000352175800006
PM 25614458
OA Bronze
DA 2025-06-11
ER

PT J
AU Ziobro, A
   Duchnowicz, P
   Mulik, A
   Koter-Michalak, M
   Broncel, M
AF Ziobro, A.
   Duchnowicz, P.
   Mulik, A.
   Koter-Michalak, M.
   Broncel, M.
TI Oxidative damages in erythrocytes of patients with metabolic syndrome
SO MOLECULAR AND CELLULAR BIOCHEMISTRY
LA English
DT Article
DE Metabolic syndrome; Erythrocyte; Oxidative damage; Cholesterol;
   Antioxidant enzymes; Glutathione; Lipid peroxidation
ID FAT OVERLOAD; MEMBRANE; STRESS; LIPIDS; AUTOXIDATION; ASSOCIATION;
   PROTEIN
AB The aim of the study was to estimate the changes caused by oxidative stress in structure and function of membrane of erythrocytes from patients with metabolic syndrome (MS). The study involved 85 patients with MS before pharmacological treatment and 75 healthy volunteers as a control group. Cholesterol level, lipid peroxidation, glutathione level (GSH), and antioxidant enzyme activities in erythrocytes were investigated. The damage to erythrocyte proteins was also indicated by means of activity of ATPase (total and Na+, K+ ATPase) and thiol group level. The membrane fluidity of erythrocytes was estimated by the fluorescent method. The cholesterol concentration and the level of lipid peroxidation were significantly higher, whereas the concentration of proteins thiol groups decreased in the patient group. ATPase and GSH peroxidase activities diminished compared to those in the control group. There were no differences in either catalase or superoxide dismutase activities. The membrane fluidity was lower in erythrocytes from patients with MS than in the ones from control group. These results show changes in red blood cells of patients with MS as a consequence of a higher concentration of cholesterol in the membrane and an increased oxidative stress.
C1 [Ziobro, A.; Duchnowicz, P.; Mulik, A.; Koter-Michalak, M.] Univ Lodz, Dept Environm Pollut Biophys, Fac Biol & Environm Protect, PL-90237 Lodz, Poland.
   [Broncel, M.] Med Univ Lodz, Dept Internal Dis & Clin Pharmacol, PL-91347 Lodz, Poland.
C3 University of Lodz; Medical University Lodz
RP Koter-Michalak, M (corresponding author), Univ Lodz, Dept Environm Pollut Biophys, Fac Biol & Environm Protect, 141-143 Pomorska St, PL-90237 Lodz, Poland.
EM koterm@biol.uni.lodz.pl
RI Duchnowicz, Piotr/F-2162-2018
OI Duchnowicz, Piotr/0000-0002-3514-9716; Broncel,
   Marlena/0000-0003-3659-8115; Ziobro, Anna/0000-0001-6574-7461;
   Koter-Michalak, Maria/0000-0001-8660-4136
FU University of Lodz [506/982]; Medical University of Lodz [503-5006-3]
FX This study was supported by the University of Lodz, Grant 506/982, and
   by the Medical University of Lodz, Grant 503-5006-3.
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NR 41
TC 28
Z9 33
U1 0
U2 18
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0300-8177
EI 1573-4919
J9 MOL CELL BIOCHEM
JI Mol. Cell. Biochem.
PD JUN
PY 2013
VL 378
IS 1-2
BP 267
EP 273
DI 10.1007/s11010-013-1617-7
PG 7
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA 134BG
UT WOS:000318184100028
PM 23516039
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Wheeler, AJ
   O'Reilly, CL
   El-Den, S
   Byrnes, J
   Ware, RS
   McMillan, SS
AF Wheeler, Amanda J.
   O'Reilly, Claire L.
   El-Den, Sarira
   Byrnes, Joshua
   Ware, Robert S.
   McMillan, Sara S.
TI Bridging the gap between physical and mental illness in community
   pharmacy (PharMIbridge): protocol for an Australian cluster
   randomised controlled trial
SO BMJ OPEN
LA English
DT Article
DE mental health; education and training (see medical education and
   training); public health; protocols and guidelines
ID MEDICATION SUPPORT SERVICE; PHARMACEUTICAL CARE; HEALTH CONSUMERS;
   ADHERENCE; ATTITUDES; IMPACT; PEOPLE; INTERVENTIONS; DEPRESSION;
   RELIABILITY
AB Introduction There is a significant life expectancy gap attributable to physical comorbidities for people living with severe and persistent mental illness (SPMI) compared with the general population. Medications are a major treatment for SPMI management and physical illnesses, hence pharmacists are well positioned to support mental healthcare and comorbidities. The randomised controlled trial (RCT) aim is to evaluate effectiveness of an individualised, pharmacist led, support service for people experiencing SPMI focusing on medication adherence and physical comorbidity management, compared with standard care (a medication-management service; MedsCheck).
   Methods and analysis PharMIbridgeis a cluster RCT, whereby community pharmacies in four Australian regions will be randomised (1:1 ratio), to either Intervention Group (IG) or Comparator Group (CG). All IG and CG pharmacy staff will receive Blended-Mental Health First Aid training. Additionally, IG pharmacists will receive further training on medication adherence, goal setting, motivational interviewing, managing physical health concerns and complex issues relating to psychotropic medication. CG pharmacists will not receive additional training, and will provide standard care (MedsCheck). The primary outcome will be change in participants medication adherence for psychotropic medication over 6-months. Using mixed-effects logistic regression model and a cluster size of 48 pharmacies, a total of 190 participants will need to be recruited to each arm to find a statistically significant difference in medication adherence. Secondary outcomes will be changes in factors associated with cardiometabolic risk and quality of life, emphasising physical and psychological well-being; medication-related problems; adherence to other prescribed medication; pharmacists knowledge, confidence and ability to support people experiencing SPMI; and effects on healthcare utilisation. A within RCT-based economic evaluation comparing the intervention with standard care will be undertaken.
   Ethics and dissemination The protocol and pharmacist training programme received Griffith University Human Research Ethics Committee approval (HREC/2019/473 and HREC/2019/493 respectively). Results will be published in peer-reviewed journals and available at the Sixth Community Pharmacy Agreement website (http://6cpa. com.au/about-6cpa/).
C1 [Wheeler, Amanda J.; Byrnes, Joshua; Ware, Robert S.; McMillan, Sara S.] Griffith Univ, Menzies Hlth Inst Queensland, Brisbane, Qld, Australia.
   [Wheeler, Amanda J.] Auckland Univ, Fac Med & Hlth Sci, Auckland, New Zealand.
   [O'Reilly, Claire L.; El-Den, Sarira] Univ Sydney, Fac Med & Hlth, Sydney Pharm Sch, Sydney, NSW, Australia.
   [McMillan, Sara S.] Griffith Univ, Sch Pharm & Pharmacol, Gold Coast, Qld, Australia.
C3 Griffith University; Menzies Health Institute Queensland; University of
   Auckland; University of Sydney; Griffith University; Griffith University
   - Gold Coast Campus
RP Wheeler, AJ (corresponding author), Griffith Univ, Menzies Hlth Inst Queensland, Brisbane, Qld, Australia.; Wheeler, AJ (corresponding author), Auckland Univ, Fac Med & Hlth Sci, Auckland, New Zealand.
EM a.wheeler@griffith.edu.au
RI Byrnes, Josh/AAA-4387-2021; Wheeler, Amanda/F-1854-2011; McMillan,
   Sara/AAD-2532-2020; Ware, Robert/B-2024-2014
OI Wheeler, Amanda/0000-0001-9755-674X; O'Reilly,
   Claire/0000-0001-6416-8150; McMillan, Sara/0000-0003-3427-4467; Ware,
   Robert/0000-0002-6129-6736
FU Australian Government
FX This activity received grant funding from the Australian Government.
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NR 80
TC 28
Z9 28
U1 1
U2 3
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2044-6055
J9 BMJ OPEN
JI BMJ Open
PY 2020
VL 10
IS 7
AR e039983
DI 10.1136/bmjopen-2020-039983
PG 13
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA WT1EO
UT WOS:000715614800037
PM 32709657
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Mintoff, D
   Agius, R
   Fava, S
   Pace, NP
AF Mintoff, Dillon
   Agius, Rachel
   Fava, Stephen
   Pace, Nikolai P.
TI Investigating Adiposity-Related Metabolic Health Phenotypes in Patients
   with Hidradenitis Suppurativa: A Cross-Sectional Study
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Article
DE hidradenitis suppurativa; obesity; phenotypes; metabolic health
ID NORMAL-WEIGHT; OBESITY; INFLAMMATION; INDIVIDUALS; STRESS; INDEX; RISK
AB Background: Obesity and hidradenitis suppurativa (HS) are related through meta-inflammation and are both associated with increased cardiometabolic risk. Notwithstanding, cardiometabolic pathology is not uniform in obesity and a subset of individuals with excess adiposity exhibit a healthy metabolic profile. Whilst the incidence of cardiometabolic endpoints and transitions across different adiposity-related body composition phenotypes within several populations and across different ethnicities have been investigated, data regarding metabolic health (MetH) and body composition phenotypes in individuals with HS are lacking. The objective of this study was to evaluate the relationship between different body composition phenotypes in individuals with HS. Methods: This was a cross-sectional study of 632 individuals with and without HS from a population with a high prevalence of both obesity and HS. A total of four body composition phenotypes were generated based on BMI and metabolic status (defined using either the metabolic syndrome definition or the homeostasis model of insulin resistance (HOMA-IR)): metabolically healthy overweight/obese (MHOWOB), metabolically unhealthy overweight/obese (MUOWOB), metabolically healthy normal weight (MHNW), and metabolically unhealthy normal weight (MUNW). Results: Generally, subjects with HS exhibited a worse metabolic profile with higher levels of indices of central adiposity measures (including Visceral Adiposity Index and waist circumference), systolic blood pressure and markers of insulin resistance, as well as a higher prevalence of the metabolic syndrome. Moreover, when sub-stratified into the different body composition phenotypes, individuals with HS typically also demonstrated adverse metabolic characteristics relative to controls matched for both adiposity and metabolic health, particularly in the normal weight category and despite being classified as metabolically healthy. Being metabolically unhealthy in addition to being overweight/obese increases an individual's risk of HS. Conclusions: Metabolic risk-assessment should be prioritized in the clinical management of individuals with HS even in those who are lean. Patients attending HS clinics provide a valuable opportunity for targeted cardiovascular risk reduction with respect to the management of both obesity and metabolic health.
C1 [Mintoff, Dillon] Univ Malta, Fac Med & Surg, Dept Pathol, MSD-2080 Msida, Malta.
   [Mintoff, Dillon] Mater Dei Hosp, Dept Dermatol, MSD-2090 Msida, Malta.
   [Agius, Rachel; Fava, Stephen] Univ Malta, Fac Med & Surg, Dept Med, MSD-2080 Msida, Malta.
   [Agius, Rachel; Fava, Stephen] Mater Dei Hosp, Dept Med, MSD-2090 Msida, Malta.
   [Pace, Nikolai P.] Univ Malta, Fac Med & Surg, Dept Anat, MSD-2080 Msida, Malta.
   [Pace, Nikolai P.] Univ Malta, Ctr Mol Med & Biobanking, MSD-2080 Msida, Malta.
C3 University of Malta; University of Malta; University of Malta;
   University of Malta
RP Pace, NP (corresponding author), Univ Malta, Fac Med & Surg, Dept Anat, MSD-2080 Msida, Malta.; Pace, NP (corresponding author), Univ Malta, Ctr Mol Med & Biobanking, MSD-2080 Msida, Malta.
EM dillon.mintoff@gov.mt; rachel.agius@gov.mt; stephen.fava@gov.mt;
   nikolai.p.pace@um.edu.mt
RI Mintoff, Dillon/ABG-2301-2020; Pace, Nikolai/AAY-2233-2021; Fava,
   S/D-8599-2012
OI Mintoff, Dillon/0000-0003-3705-0119; Agius, Rachel/0000-0002-4547-6008;
   Pace, Nikolai Paul/0000-0002-7332-874X
FU UNIVERSITY OF MALTA; GOVERNMENT OF MALTA
FX This research was funded by UNIVERSITY OF MALTA, institutional funds and
   GOVERNMENT OF MALTA, tertiary education scholarship scheme and The APC
   was funded by UNIVERSITY OF MALTA, institutional funds.
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NR 42
TC 10
Z9 10
U1 0
U2 4
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD JUL
PY 2023
VL 12
IS 14
AR 4847
DI 10.3390/jcm12144847
PG 13
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA N7BE2
UT WOS:001038513600001
PM 37510962
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Idung, AU
   Abasiubong, F
   Udoh, SB
   Akinbami, OS
AF Idung, Alphonsus U.
   Abasiubong, Festus
   Udoh, Sunday B.
   Akinbami, Oluyinka S.
TI Quality of life in patients with erectile dysfunction in the Niger Delta
   region, Nigeria
SO JOURNAL OF MENTAL HEALTH
LA English
DT Article
DE sexual satisfaction; quality of life; erectile dysfunction; Nigeria
ID INTERNATIONAL INDEX; METABOLIC SYNDROME; DIAGNOSTIC-TOOL; FUNCTION
   IIEF-5; MEN; PREVALENCE; DISEASE; VERSION
AB Background: Erectile dysfunction (ED) in men is increasingly becoming a major problem worldwide. The damaging effects on the psyche and the anxiety regarding sexual performance and overall life satisfaction could be irreversible.
   Aims: The objective of this study was to compare domains of quality of life (QOL) in men with ED in the Niger Delta region of Nigeria in order to determine the contextual social variables.
   Method.: In a cross-sectional study, 400 male patients attending the general outpatient clinic between January and March 2009 were randomly assessed for ED and QOL, using abridged version of the International Index of Erectile function and the World Health Organization Quality of life instrument.
   Results: A total of 166 (41.7%) subjects suffered from ED, 80 (48.2%) from medical illness, 56 (33.7%) from surgical problems and 30 (18.1%) from undiagnosed problems. Social relationships and psychological health indices of QOL were severely impaired in men with ED than the general, overall, physical and environmental health.
   Conclusion: An inference from this study suggests that sexual function promotes psychological wellbeing as well as interpersonal relationships. Therefore, monitoring these indices of QOL in men with ED is important to boost their confidence and self-esteem needed for a better QOL.
C1 [Abasiubong, Festus] Univ Uyo, Coll Hlth Sci, Fac Clin Sci, Dept Psychiat, Uyo, Akwa Ibom State, Nigeria.
   [Idung, Alphonsus U.; Udoh, Sunday B.; Akinbami, Oluyinka S.] Univ Uyo, Dept Family Med, Uyo, Akwa Ibom State, Nigeria.
C3 University of Uyo; University of Uyo
RP Abasiubong, F (corresponding author), Univ Uyo, Coll Hlth Sci, Fac Clin Sci, Dept Psychiat, Uyo, Akwa Ibom State, Nigeria.
EM fesab2000@yahoo.com
RI Abasiubong, Festus/IVH-9746-2023; Udoh, Sunday/HLH-1463-2023
OI Udoh, Sunday/0000-0002-0888-4141; Abasiubong, Festus/0009-0000-5232-7652
CR Abolfotouh M. A., 2001, Eastern Mediterranean Health Journal, V7, P510
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NR 35
TC 17
Z9 18
U1 0
U2 5
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 0963-8237
EI 1360-0567
J9 J MENT HEALTH
JI J. Ment. Heal.
PD JUN
PY 2012
VL 21
IS 3
BP 236
EP 243
DI 10.3109/09638237.2012.664300
PG 8
WC Psychology, Clinical; Psychiatry
WE Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA 942SH
UT WOS:000304066800003
PM 22574953
DA 2025-06-11
ER

PT J
AU Grassi, G
   Seravalle, G
   Brambilla, G
   Facchetti, R
   Bolla, G
   Mozzi, E
   Mancia, G
AF Grassi, Guido
   Seravalle, Gino
   Brambilla, Gianmaria
   Facchetti, Rita
   Bolla, Gianbattista
   Mozzi, Enrico
   Mancia, Giuseppe
TI Impact of the metabolic syndrome on subcutaneous microcirculation in
   obese patients
SO JOURNAL OF HYPERTENSION
LA English
DT Article; Proceedings Paper
CT 15th European Meeting on Hypertension
CY JUN 17-21, 2005
CL Milan, ITALY
SP European Soc Hypertens, AstraZeneca, Bristol-Myers Squibb Co, Boehringer Ingelheim, MSD, NOVARTIS, RECORDATI, SANKYO, Sanofi Aventis, Bayer Hlthcare, Pfizer Inc, Solvay Pharmaceut GmbH
DE endothelial function; metabolic syndrome; microcirculation; obesity;
   small resistance arteries
ID SMALL-RESISTANCE ARTERIES; ENDOTHELIAL DYSFUNCTION; INSULIN-RESISTANCE;
   STRUCTURAL ALTERATIONS; CARDIOVASCULAR EVENTS; DIABETIC-PATIENTS;
   HYPERTENSION; WOMEN; DETERMINANTS; INFLAMMATION
AB Objectives Patients with the metabolic syndrome are at increased cardiovascular risk and display an augmented wall stiffness of the large-sized and medium-sized arteries, coupled with an endothelial dysfunction. Whether this is the case also for the small resistance arteries is unknown, however. It is also unknown whether and to what extent the hypothesized microvascular alterations are greater for magnitude than the ones characterizing obesity, that is the most common component of the metabolic syndrome.
   Methods In 14 lean healthy controls (age 48.7 +/- 2.4 years, mean +/- SEM), 13 obese participants and 12 individuals with the metabolic syndrome (Adult Treatment Panel III criteria), all age-matched with healthy controls, we assessed the small resistance arteries dissected from the abdominal subcutaneous tissue on a pressurized myograph.
   Results The media thickness, media cross-sectional area (CSA) and media-to-lumen ratio (M/L) of the small resistance arteries were markedly and significantly greater in metabolic syndrome than in controls (media thickness: 28.3 +/- 0.7 vs. 17.5 +/- 0.3 mu m; CSA: 24 760.8 +/- 1459 vs. 16 170.7 +/- 843.6 mu m(2) and M/L: 0.12 +/- 0.01 vs. 0.064 +/- 0.002 a.u., respectively, P<0.01 for all). Acetylcholine-induced relaxation was impaired in the vessels from metabolic syndrome participants compared with the lean healthy individuals (-48.8%, P<0.01), whereas endothelium-independent vasorelaxation was similar in the two groups. The structural and functional microvascular alterations seen in metabolic syndrome were slightly, although not significantly, greater than the ones seen in uncomplicated obese participants. Stiffness of small arteries, as assessed by the stress/strain relationship, was also similar in the three groups of participants.
   Conclusion Thus, metabolic syndrome is characterized by marked alterations in the structural and functional patterns of the small resistance arteries. These alterations, which are only slightly greater than the ones seen in obesity, may be responsible for the increased incidence of coronary and cerebrovascular events reported in metabolic syndrome. J Hypertens 28: 1708-1714 (c) 2010 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
C1 [Grassi, Guido; Mancia, Giuseppe] Univ Milano Bicocca, Dipartimento Med Clin Prevenz & Biotecnol Sanit, Med Clin, Osped San Gerardo, Monza, Italy.
   [Grassi, Guido; Seravalle, Gino] IRCCS, Ist Auxol Italiano, Sesto San Giovanni, Italy.
   [Brambilla, Gianmaria; Facchetti, Rita] IRCCS, Ist Sci Multimed, Sesto San Giovanni, Italy.
   [Bolla, Gianbattista] Osped Policlin, Ctr Interuniv Fisiol Clin & Ipertens, Milan, Italy.
   [Mozzi, Enrico] Osped Policlin, Clin Chirurg, Milan, Italy.
C3 San Gerardo Hospital; University of Milano-Bicocca; IRCCS Istituto
   Auxologico Italiano
RP Grassi, G (corresponding author), Osped S Gerardo dei Tintori, Med Clin, Via Pergolesi 33, I-20052 Milan, Italy.
EM guido.grassi@unimib.it
RI MANCIA, GIUSEPPE/AGF-9410-2022; seravalle, gino/K-1442-2019
OI seravalle, gino/0000-0003-3638-8011; Mozzi, Enrico/0000-0002-9107-1714
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NR 39
TC 27
Z9 29
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0263-6352
EI 1473-5598
J9 J HYPERTENS
JI J. Hypertens.
PD AUG
PY 2010
VL 28
IS 8
BP 1708
EP 1714
DI 10.1097/HJH.0b013e32833af3c9
PG 7
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Cardiovascular System & Cardiology
GA 628JJ
UT WOS:000280115300016
PM 20520576
DA 2025-06-11
ER

PT J
AU Oke, SL
   Hardy, DB
AF Oke, Shelby L.
   Hardy, Daniel B.
TI The Role of Cellular Stress in Intrauterine Growth Restriction and
   Postnatal Dysmetabolism
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE intrauterine growth restriction (IUGR); metabolism; cell stress; cell
   death; metabolic syndrome
ID MATERNAL PROTEIN RESTRICTION; LOW-BIRTH-WEIGHT; ENDOPLASMIC-RETICULUM
   STRESS; NICOTINE EXPOSURE LEADS; OXIDATIVE STRESS; SKELETAL-MUSCLE;
   LONG-TERM; MITOCHONDRIAL DYSFUNCTION; INSULIN-RESISTANCE;
   GENE-EXPRESSION
AB Disruption of the in utero environment can have dire consequences on fetal growth and development. Intrauterine growth restriction (IUGR) is a pathological condition by which the fetus deviates from its expected growth trajectory, resulting in low birth weight and impaired organ function. The developmental origins of health and disease (DOHaD) postulates that IUGR has lifelong consequences on offspring well-being, as human studies have established an inverse relationship between birth weight and long-term metabolic health. While these trends are apparent in epidemiological data, animal studies have been essential in defining the molecular mechanisms that contribute to this relationship. One such mechanism is cellular stress, a prominent underlying cause of the metabolic syndrome. As such, this review considers the role of oxidative stress, mitochondrial dysfunction, endoplasmic reticulum (ER) stress, and inflammation in the pathogenesis of metabolic disease in IUGR offspring. In addition, we summarize how uncontrolled cellular stress can lead to programmed cell death within the metabolic organs of IUGR offspring.
C1 [Oke, Shelby L.; Hardy, Daniel B.] Western Univ, Schulich Sch Med & Dent, Dept Physiol & Pharmacol, 1151 Richmond St, London, ON N6A 5C1, Canada.
   [Oke, Shelby L.; Hardy, Daniel B.] Lawson Hlth Res Inst, Childrens Hlth Res Inst, London, ON N6A 5C1, Canada.
   [Hardy, Daniel B.] Univ Western Ontario, Schulich Sch Med & Dent, Dept Obstet & Gynaecol, 1151 Richmond St, London, ON N6A 5C1, Canada.
C3 Western University (University of Western Ontario); Western University
   (University of Western Ontario); University Western Ontario Hospital;
   Western University (University of Western Ontario)
RP Hardy, DB (corresponding author), Western Univ, Schulich Sch Med & Dent, Dept Physiol & Pharmacol, 1151 Richmond St, London, ON N6A 5C1, Canada.; Hardy, DB (corresponding author), Lawson Hlth Res Inst, Childrens Hlth Res Inst, London, ON N6A 5C1, Canada.; Hardy, DB (corresponding author), Univ Western Ontario, Schulich Sch Med & Dent, Dept Obstet & Gynaecol, 1151 Richmond St, London, ON N6A 5C1, Canada.
EM soke2@uwo.ca; daniel.hardy@schulich.uwo.ca
RI Hardy, Daniel/GYU-8976-2022
OI Hardy, Daniel/0000-0001-5445-273X
FU Natural Sciences and Engineering Research Council of Canada (NSERC)
   [RGPIN-2021-04164]; NSERC CGS-D
FX This work was supported by a Natural Sciences and Engineering Research
   Council of Canada (NSERC) Discovery Grant (RGPIN-2021-04164) awarded to
   DBH and an NSERC CGS-D awarded to SLO.
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NR 117
TC 23
Z9 25
U1 0
U2 9
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD JUL
PY 2021
VL 22
IS 13
AR 6986
DI 10.3390/ijms22136986
PG 17
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA TG7XY
UT WOS:000671614000001
PM 34209700
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Liu, JN
   Xu, JH
   Guan, SB
   Wang, W
AF Liu, Jianing
   Xu, Jiahuan
   Guan, Shibo
   Wang, Wei
TI Effects of different treatments on metabolic syndrome in patients with
   obstructive sleep apnea: a meta-analysis
SO FRONTIERS IN MEDICINE
LA English
DT Article
DE obstructive sleep apnea; metabolic syndrome; continuous positive airway
   pressure; exercise; diet; surgery; meta-analysis
ID POSITIVE AIRWAY PRESSURE; CHRONIC INTERMITTENT HYPOXIA; INCREASED
   PREVALENCE; INSULIN-RESISTANCE; GLUCOSE-TOLERANCE; OXIDATIVE STRESS;
   RISK-FACTORS; MANAGEMENT; DISEASE; SENSITIVITY
AB Background: Obstructive sleep apnea (OSA) and metabolic syndrome (MetS) often coexist, and the causal relationship between them is not yet clear; treatments for OSA include continuous positive airway pressure (CPAP), mandibular advancement device (MAD), surgery, and lifestyle intervention and so on. However, the effects of different treatments on metabolic syndrome in OSA patients are still under debate. Objectives: Review the effects of different treatments on metabolic syndrome in OSA patients by meta-analysis. Methods: we searched articles in PubMed, Embase, Cochrane Library, CNKI, CBM, and Wanfang data from database construction to Feb. 2024.RevMan5.4 and Stata software were used to conduct a meta-analysis of 22 articles. Results: A total of 22 articles were finally included. The results showed that CPAP treatment could reduce the prevalence of metabolic syndrome in OSA patients in randomized controlled trials (RCTs) (RR = 0.82 [95% CI, 0.75 to 0.90]; p < 0.01) and single-arm studies (RR = 0.73 [95% CI, 0.63 to 0.84]; p < 0.01). As for metabolic syndrome components, CPAP treatment reduces blood pressure, fasting glucose (FG), triglycerides (TG), and waist circumference (WC) but can't affect high-density lipoprotein cholesterol (HDL-C) levels. Lifestyle intervention could significantly reduce the prevalence of metabolic syndrome in OSA patients (RR = 0.60 [95% CI, 0.48 to 0.74]; p < 0.01) and can lower blood pressure, fasting glucose, and waist circumference but can't affect the lipid metabolism of OSA patients. Upper airway surgery can only reduce TG levels in OSA patients (MD = -0.74 [95% CI, -1.35 to -0.13]; p = 0.02) and does not affect other components of metabolic syndrome. There is currently no report on the impact of upper airway surgery on the prevalence of metabolic syndrome. No study has reported the effect of MAD on metabolic syndrome in OSA patients. Conclusion: We confirmed that both CPAP and lifestyle intervention can reduce the prevalence of MetS in OSA patients. CPAP treatment can lower blood pressure, fasting glucose, waist circumference, and triglyceride levels in OSA patients. Lifestyle intervention can lower blood pressure, fasting glucose, and waist circumference in OSA patients. Upper airway surgery can only reduce TG levels in OSA patients.
C1 [Liu, Jianing; Xu, Jiahuan; Guan, Shibo; Wang, Wei] China Med Univ, Hosp 1, Inst Resp & Crit Care Med, Shenyang, Liaoning, Peoples R China.
C3 China Medical University
RP Wang, W (corresponding author), China Med Univ, Hosp 1, Inst Resp & Crit Care Med, Shenyang, Liaoning, Peoples R China.
EM wwbycmu@126.com
FU National Natural Science Foundation of China [82270107]
FX The author(s) declare financial support was received for the research,
   authorship, and/or publication of this article. This study was supported
   by the National Natural Science Foundation of China (82270107).
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   Wang SH, 2020, AM J RESP CRIT CARE, V201, P718, DOI 10.1164/rccm.201903-0692OC
   Yunan Z., 2015, 手术干预对OSAHS合并代谢综合征患者血压、血脂及多种激素水平的影响
NR 53
TC 1
Z9 1
U1 3
U2 9
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 2296-858X
J9 FRONT MED-LAUSANNE
JI Front. Med.
PD MAR 7
PY 2024
VL 11
AR 1354489
DI 10.3389/fmed.2024.1354489
PG 13
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA LW2C6
UT WOS:001189762500001
PM 38515989
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Selvamani, I
   Sasidharan, A
   Sree, BH
   Rekha, BM
   Dondapati, S
AF Selvamani, Iniyan
   Sasidharan, Aswin
   Sree, B. Haritha
   Rekha, B. Minu
   Dondapati, Sumedha
TI Referral Pattern of Inpatients to Psychiatry Department and the
   Diagnostic Concordance between the Referral Departments and Psychiatry
   Team- A Retrospective Study
SO JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH
LA English
DT Article
DE Alcohol; Delirium; Depression; Kappa
ID MEDICAL INPATIENTS; PREVALENCE; DISORDERS
AB Introduction: The referral of inpatients to psychiatry team is more in India due to the increase in the morbidity rates of people. The referrals to Psychiatric Department with a specific psychiatric diagnosis are considerably very low. Most often, the diagnosis made by the clinicians doesn't match with that of the psychiatrist. Physical illness is shown to have a strong association with psychiatric co-morbidity. Such association complicates the course and outcome of both the conditions.Aim: To evaluate the pattern of inpatient referral to the Psychiatric Department and to estimate the diagnostic concordance between the referral and psychiatric team.Materials and Methods: This retrospective study, with prior permission from the Department of psychiatry, included all the inpatient referrals (n=310) to Psychiatry Department by other departments from January 2019 to December 2019. Data collection was done from March 2020 to August 2020 and data analysis from September 2020 to November 2020, in Saveetha Medical College and Hospital, Chennai, Tamil Nadu, India. Data was obtained from a psychiatry referral register and was statistically analysed using Microsoft Excel (MS Office 2013) for percentage, mean and Standard Deviation (SD) for descriptive variables. Diagnostic concordance to assess the reason for referral and diagnostic accuracy in terms of reason of referral and psychiatric diagnosis was analysed using kappa statistics.Results: The most common psychiatric disorder for referral was alcohol dependence syndrome (n=102, 32.9%) followed by depression (n=38, 12.3%) and adjustment disorders (n=34, 10.9 %). Concordance was good for intellectual disorder (x=1.00), depression (x=0.969) and alcohol dependence syndrome (x=0.963). Very low concordance was observed in diagnosing acute confusional state (x=0.195) and panic disorder (x =0).Conclusion: Alcohol withdrawal syndrome, adjustment disorder and depression were the most common reasons in referring inpatients to psychiatry. Lower concordance for psychiatric disorders like Acute confusional state and Panic disorder could be explained by inadequate psychiatry exposure and hence be improved by better undergraduate psychiatry training.
C1 [Selvamani, Iniyan; Sasidharan, Aswin; Dondapati, Sumedha] Saveetha Med Coll & Hosp, Dept Psychiat, Chennai, Tamil Nadu, India.
   [Sree, B. Haritha] Saveetha Med Coll & Hosp, Chennai, Tamil Nadu, India.
   [Rekha, B. Minu] Govt Vellore Med, Coll Vellore, Dept Anat, Vellore, Tamil Nadu, India.
   [Selvamani, Iniyan] Saveetha Med Coll, Chennai Bengaluru, NH 48, Thandalam 602105, Tamil Nadu, India.
C3 Saveetha Institute of Medical & Technical Science; Saveetha Medical
   College & Hospital; Saveetha Institute of Medical & Technical Science;
   Saveetha Medical College & Hospital; Saveetha Institute of Medical &
   Technical Science; Saveetha Medical College & Hospital
RP Selvamani, I (corresponding author), Saveetha Med Coll, Chennai Bengaluru, NH 48, Thandalam 602105, Tamil Nadu, India.
EM iniyanmbbs@gmail.com
CR Al-Atram AA, 2018, KUWAIT MED J, V50, P410
   Alhamad A. M., 2006, Eastern Mediterranean Health Journal, V12, P324
   Alhamad A. M., 2006, Eastern Mediterranean Health Journal, V12, P316
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   [Anonymous], 2010, ICD 10 VERSION
   Avasthi A, 1998, Indian J Psychiatry, V40, P224
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   Liu SI, 2008, J FORMOS MED ASSOC, V107, P921, DOI 10.1016/S0929-6646(09)60015-2
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NR 14
TC 0
Z9 0
U1 0
U2 0
PU PREMCHAND SHANTIDEVI RESEARCH FOUNDATION
PI DELHI
PA 71 JAIN COLONY, VEER NAGAR, DELHI, 110 007, INDIA
SN 2249-782X
EI 0973-709X
J9 J CLIN DIAGN RES
JI J. Clin. Diagn. Res.
PD AUG
PY 2022
VL 16
IS 8
BP VC6
EP VC9
DI 10.7860/JCDR/2022/55526.16809
PG 4
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA 6N3OG
UT WOS:000889467000002
OA gold
DA 2025-06-11
ER

PT J
AU Sagar, R
   Sen, MS
   Kumar, N
   Chawla, N
AF Sagar, Rajesh
   Sen, Mahadev Singh
   Kumar, Nand
   Chawla, Nishtha
TI Longitudinal assessment of disability amongst patients of bipolar and
   unipolar depressive disorders presenting to a tertiary care center in
   North India
SO INTERNATIONAL JOURNAL OF SOCIAL PSYCHIATRY
LA English
DT Article
DE Disability; mood disorders; depressive disorders; bipolar depression;
   unipolar depression
ID PSYCHOSOCIAL DISABILITY; METABOLIC SYNDROME; VALIDITY; ADULTS; SCALE
AB Objectives: To assess and compare the changes in disability scores associated with Bipolar Depression (BD) and Unipolar Depression (UD) over 1 year. Methods: A longitudinal study was taken up in adults diagnosed with unipolar or bipolar depressive disorder with current depressive episode. Diagnosis was made according to Schedule for Clinical Assessment in Neuropsychiatry. Severity scoring was done using Hamilton's Depression (HAM-D) rating scale and Hamilton's Anxiety (HAM-A) rating scale. Disability was assessed using Indian Disability Evaluation and Assessment Scale (IDEAS) and London handicap Scale (LHS) at baseline, 6 and 12 months. Results: Sixty participants were recruited (42 UD and 18 BD). No significant differences were seen in socio-demographic parameters, except higher education levels and males being overrepresented in UD. Significant differences at baseline were seen in HAM-D (p = .001) and HAM-A (p = .003) scores. The extent of disability was seen to correlate with severity of illness only in case of BD at baseline. No significant differences were seen in the IDEAS scores at baseline. IDEAS score improved at each follow-up assessment (p < .001). LHS showed significant improvement over time in UD (p < .001), but not BD (p = .076). Percentage individuals meeting cut-off for benchmark disability (>40%) were comparable at baseline but were significantly more in the BD at 12-months (p = .049). Conclusion and implications: Disability in psychiatry occurs equally amongst unipolar and bipolar depressive disorders and tends to improve over time, although the level of improvement may differ. It may not always correspond to severity of illness. These factors should be considered while certifying disability.
C1 [Sagar, Rajesh; Sen, Mahadev Singh; Kumar, Nand; Chawla, Nishtha] All India Inst Med Sci, Dept Psychiat, 4089,4th Floor, New Delhi 110029, India.
C3 All India Institute of Medical Sciences (AIIMS) New Delhi
RP Sagar, R (corresponding author), All India Inst Med Sci, Dept Psychiat, 4089,4th Floor, New Delhi 110029, India.
EM rsagar29@gmail.com
RI Sagar, Rajesh/L-7775-2016; Chawla, Nishtha/AAV-2770-2021; Singh Sen,
   Mahadev/AAV-2767-2021
OI Singh Sen, Mahadev/0000-0002-6433-8428; SAGAR,
   RAJESH/0000-0003-4563-7841
FU WHO (India) [SE/02/413325]
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: The study
   was funded by the WHO (India) (Sticker No. SE/02/413325).
CR Chang FH, 2012, ARCH PHYS MED REHAB, V93, P2264, DOI 10.1016/j.apmr.2012.06.008
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NR 26
TC 3
Z9 2
U1 0
U2 2
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0020-7640
EI 1741-2854
J9 INT J SOC PSYCHIATR
JI Int. J. Soc. Psychiatr.
PD FEB
PY 2023
VL 69
IS 1
BP 70
EP 77
AR 00207640211070158
DI 10.1177/00207640211070158
EA JAN 2022
PG 8
WC Psychiatry
WE Social Science Citation Index (SSCI)
SC Psychiatry
GA 9C3VV
UT WOS:000746555200001
PM 34996324
DA 2025-06-11
ER

PT J
AU Hulbert, AJ
   Turner, N
   Storlien, LH
   Else, PL
AF Hulbert, AJ
   Turner, N
   Storlien, LH
   Else, PL
TI Dietary fats and membrane function: implications for metabolism and
   disease
SO BIOLOGICAL REVIEWS
LA English
DT Review
DE lipids; phospholipids; membranes; metabolism; diet; fats; omega-3;
   omega-6; saturated fats; mono-unsaturated fats; fatty acids; metabolic
   syndrome; mental illness; mental health; docosahexaenoic acid
ID SAFFLOWER OIL DIET; ACID-COMPOSITION; DOCOSAHEXAENOIC ACID; FISH
   CONSUMPTION; SKELETAL-MUSCLE; INSULIN SENSITIVITY; MOLECULAR ACTIVITY;
   LIPID-COMPOSITION; ACYL COMPOSITION; DOUBLE-BLIND
AB Lipids play varied and critical roles in metabolism, with function dramatically modulated by the individual fatty acid mottles in complex lipid entities. In particular, the fatty acid composition of membrane lipids greatly influences membrane function. Here we consider the role of dietary fatty acid profile on membrane composition and, in turn, its impact on prevalent disease clusters of the metabolic syndrome and mental illness. Applying the classical physiological conformer-regulator paradigm to quantify the influence of dietary fats on membrane lipid composition (i.e. where the membrane variable is plotted against the same variable in the environment - in this case dietary fats), membrane lipid composition appears as a predominantly regulated parameter. Membranes remain relatively constant in their saturated (SFA) and monounsaturated (MUFA) fatty acid levels over a wide range of dietary variation for these fatty acids. Membrane composition was found to be more responsive to n-6 and n-3 polyunsaturated fatty acid (PUFA) levels in the diet and most sensitive to n-3 PUFA and to the n-3/n-6 ratio. These diffierential responses are probably due to the fact that both n-6 and n-3 PUFA classes cannot be synthesised de novo by higher animals. Diet-induced modifications in membrane lipid composition are associated with changes in the rates of membrane-linked cellular processes that are major contributors to energy metabolism. For example, in the intrinsic activity of fundamental processes such as the Na+/K+ pump and proton pump-leak cycle. Equally, dietary lipid profile impacts substantially on diseases of the metabolic syndrome with evidence accruing for changes in metabolic rate and neuropeptide regulation (thus influencing both sides of the energy balance equation), in second messenger generation and in gene expression influencing a range of glucose and lipid handling pathways. Finally, there is a growing literature relating changes in dietary fatty acid profile to many aspects of mental health. The understanding of dietary lipid profile and its influence on membrane function in relation to metabolic dysregulation has exciting potential for the prevention and treatment of a range of prevalent disease states.
C1 Univ Wollongong, Metab Res Ctr, Wollongong, NSW 2522, Australia.
   Univ Wollongong, Sch Biol Sci, Wollongong, NSW 2522, Australia.
   Univ Wollongong, Dept Biomed Sci, Wollongong, NSW 2522, Australia.
   AstraZeneca, R&D, S-43183 Molndal, Sweden.
C3 University of Wollongong; University of Wollongong; University of
   Wollongong; AstraZeneca
RP Univ Wollongong, Metab Res Ctr, Wollongong, NSW 2522, Australia.
EM pelse@uow.edu.au
RI Else, Paul/AAX-1636-2020; Turner, Nigel/H-7176-2013
OI Else, Paul/0000-0001-9368-3231; Turner, Nigel/0000-0002-0119-9328
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NR 101
TC 280
Z9 321
U1 2
U2 62
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1464-7931
EI 1469-185X
J9 BIOL REV
JI Biol. Rev.
PD FEB
PY 2005
VL 80
IS 1
BP 155
EP 169
DI 10.1017/S1464793104006578
PG 15
WC Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics
GA 903II
UT WOS:000227418900007
PM 15727042
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Greggersen, W
   Rudolf, S
   Fassbinder, E
   Dibbelt, L
   Stoeckelhuber, BM
   Hohagen, F
   Oltmanns, KM
   Kahl, KG
   Schweiger, U
AF Greggersen, Wiebke
   Rudolf, Sebastian
   Fassbinder, Eva
   Dibbelt, Leif
   Stoeckelhuber, Beate M.
   Hohagen, Fritz
   Oltmanns, Kerstin M.
   Kahl, Kai G.
   Schweiger, Ulrich
TI Major depression, borderline personality disorder, and visceral fat
   content in women
SO EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
LA English
DT Article
DE Visceral fat content; Body composition; Major depressive disorder;
   Borderline personality disorder; Metabolic syndrome; Cytokines
ID PITUITARY-ADRENAL-SYSTEM; ADVERSE CHILDHOOD EXPERIENCES; INCREASED
   INTRAABDOMINAL FAT; FASTING PLASMA-GLUCOSE; NECROSIS-FACTOR-ALPHA;
   METABOLIC SYNDROME; RISK-FACTOR; INSULIN SENSITIVITY; CARDIOVASCULAR
   RISK; ADIPOSE-TISSUE
AB Major depressive disorder (MDD) is associated with increased volumes of visceral fat and a high prevalence of the metabolic syndrome. In turn, affective disorders are frequently found in patients with borderline personality disorder (BPD). It is therefore unclear whether BPD per se may influence body composition. In order to clarify a potential relationship between BPD and body composition, we measured visceral fat content (VFC) in young depressed women with and without comorbid BPD and related this parameter to various features of the metabolic syndrome. Visceral fat content was measured by magnetic resonance imaging in 22 premenopausal women with MDD only, in 44 women with comorbid MDD and BPD, in 12 female BPD patients without MDD, and in 34 healthy women (CG). Data showed that depressed women without comorbid BPD had a 335% higher VFC and women with comorbid BPD had a 250% higher VFC than the CG women. When controlling for age, data showed significant effects of MDD on VFC (F = 8.4; P = 0.005). However, BPD, with or without MDD, was not related to VFC. Young depressed women with and without comorbid BPD display increased visceral fat content when compared to control subjects and may therefore constitute a risk group for the development of the metabolic syndrome. BPD per se is not an additive risk factor in this context.
C1 [Greggersen, Wiebke] Univ Lubeck, Klin Psychiatrie & Psychotherapie, D-23538 Lubeck, Germany.
   [Greggersen, Wiebke; Rudolf, Sebastian; Fassbinder, Eva; Hohagen, Fritz; Oltmanns, Kerstin M.; Schweiger, Ulrich] Univ Lubeck, Dept Psychiat & Psychotherapy, Lubeck, Germany.
   [Stoeckelhuber, Beate M.] Univ Lubeck, Dept Radiol, Lubeck, Germany.
   [Dibbelt, Leif] Univ Lubeck, Dept Clin Chem, Lubeck, Germany.
   [Kahl, Kai G.] Hannover Med Sch, Dept Psychiat Social Psychiat & Psychotherapy, D-3000 Hannover, Germany.
C3 University of Lubeck; University of Lubeck; University of Lubeck;
   University of Lubeck; Hannover Medical School
RP Greggersen, W (corresponding author), Univ Lubeck, Klin Psychiatrie & Psychotherapie, Ratzeburger Allee 160, D-23538 Lubeck, Germany.
EM wiebke.greggersen@psychiatrie.uk-sh.de
FU University of Luebeck [MUL 2301]
FX This study was supported by a grant of the University of Luebeck (MUL
   2301).
CR [Anonymous], PROG NEUROPSYCHOPHAR
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NR 54
TC 22
Z9 22
U1 0
U2 7
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0940-1334
J9 EUR ARCH PSY CLIN N
JI Eur. Arch. Psych. Clin. Neurosci.
PD DEC
PY 2011
VL 261
IS 8
BP 551
EP 557
DI 10.1007/s00406-011-0194-6
PG 7
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Psychiatry
GA 856EF
UT WOS:000297619500004
PM 21359599
DA 2025-06-11
ER

PT J
AU Su, ZQ
   Zeng, KX
   Feng, B
   Tang, LP
   Sun, CY
   Wang, XQ
   Li, CY
   Zheng, GJ
   Zhu, Y
AF Su, Zuqing
   Zeng, Kexue
   Feng, Bing
   Tang, Lipeng
   Sun, Chaoyue
   Wang, Xieqi
   Li, Caiyun
   Zheng, Guangjuan
   Zhu, Ying
TI Kun-Dan Decoction Ameliorates Insulin Resistance by Activating
   AMPK/mTOR-Mediated Autophagy in High-Fat Diet-Fed Rats
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Article
DE metabolic syndrome; insulin resistance; Kun-Dan decoction; AMPK;
   mTOR-mediated autophagy; network pharmacology
ID METABOLIC SYNDROME; CELLS; ACCUMULATION; INFLAMMATION; OBESITY; STRESS;
   MODEL
AB Background: Metabolic syndrome is characterized by central obesity, hyperglycemia and hyperlipidemia. Insulin resistance is the leading risk factor for metabolic syndrome. Kun-Dan decoction (KD), a traditional Chinese medicine, has been applied to treat patients with metabolic syndrome for over ten years. It is increasingly recognized that autophagy deficiency is the key cause of metabolic syndrome. Therefore, we aimed to explore whether KD can activate autophagy to improve metabolic syndrome.
   Methods: Network pharmacology was used to explore the underlying mechanism of KD in the treatment of metabolic syndrome. The high-fat diet-fed rats and oleic acid-induced LO2 cells were employed in our study. Oral glucose tolerance test and insulin tolerance test, obesity and histological examination, serum cholesterol, triglyceride, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), homeostasis model assessment of insulin resistance (HOMA-IR) and insulin sensitivity in high-fat diet-fed rats were analyzed. Furthermore, the protein expressions of adenosine 5'-monophosphate (AMP)-activated protein kinase (AMPK), phospho-AMPK, mammalian target of rapamycin (mTOR), phospho-mTOR, p62, autophagy related protein (Atg) 5, Atg7, Atg12, Atg13, Atg16L1 and microtubule-associated protein 1A/1B-light chain 3 (LC3)-II/ROMAN NUMERAL ONE were examined in rats and LO2 cells. Moreover, autophagy activator rapamycin and inhibitor 3-methyladenine, and small interfering RNA against Atg7 were utilized to verify the role of autophagy in the treatment of metabolic syndrome by KD in oleic acid-induced LO2 cells.
   Results: Results from network pharmacology indicated that targeted insulin resistance might be the critical mechanism of KD in the treatment of metabolic syndrome. We found that KD significantly suppressed obesity, serum cholesterol, triglyceride and LDL-C levels and increased serum HDL-C level in high-fat diet-fed rats. Furthermore, KD enhanced insulin sensitivity and attenuated HOMA-IR in high-fat diet-fed rats. Western blot showed that KD could enhance autophagy to increase the insulin sensitivity of high-fat diet-fed rats and oleic acid-induced LO2 cells. Furthermore, 3-methyladenine and small interfering RNA against Atg7 could reverse the protective effect of KD on LO2 cells. However, rapamycin could cooperate with KD to enhance autophagic activation to increase insulin sensitivity in LO2 cells.
   Conclusion: The induction of autophagy may be the major mechanism for KD to improve insulin resistance and metabolic syndrome.
C1 [Su, Zuqing; Zeng, Kexue; Feng, Bing; Tang, Lipeng; Sun, Chaoyue; Wang, Xieqi; Li, Caiyun; Zheng, Guangjuan; Zhu, Ying] Guangzhou Univ Chinese Med, Guangdong Prov Hosp Chinese Med, Clin Coll 2, Guangzhou, Peoples R China.
C3 Guangzhou University of Chinese Medicine
RP Zheng, GJ; Zhu, Y (corresponding author), Guangzhou Univ Chinese Med, Guangdong Prov Hosp Chinese Med, Clin Coll 2, Guangzhou, Peoples R China.
EM zhengguangjuan@gzucm.edu.cn; zhuying3340@gzucm.edu.cn
RI li, caiyun/KOC-3929-2024; Tang, Lipeng/ABB-6481-2020; Zheng,
   Guangjuan/ABB-6496-2020
FU National Natural Science Foundation of China [81703770]; Chinese
   Medicine Scientific Research and Technology Research Projects of
   Guangdong Provincial Hospital of Chinese Medicine [YN2018QJ04,
   YN2019QJ10]; Guangdong Provincial Key Laboratory of Chinese Medicine for
   Prevention and Treatment of Refractory Chronic Diseases [2018B030322012]
FX This work was supported by grants from the National Natural Science
   Foundation of China (grant number 81703770), the Chinese Medicine
   Scientific Research and Technology Research Projects of Guangdong
   Provincial Hospital of Chinese Medicine (grant number YN2018QJ04 and
   YN2019QJ10) and Guangdong Provincial Key Laboratory of Chinese Medicine
   for Prevention and Treatment of Refractory Chronic Diseases (grant
   number 2018B030322012).
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NR 53
TC 13
Z9 14
U1 1
U2 35
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD MAY 28
PY 2021
VL 12
AR 670151
DI 10.3389/fphar.2021.670151
PG 24
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA SQ0RG
UT WOS:000660068100001
PM 34122092
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Leone, M
   Lalande, D
   Thériault, L
   Kalinova, É
   Fortin, A
AF Leone, Mario
   Lalande, Daniel
   Theriault, Linda
   Kalinova, Emilia
   Fortin, Audrey
TI Effects of an exercise program on the physiological, biological and
   psychological profiles in patients with mood disorders: a pilot study
SO INTERNATIONAL JOURNAL OF PSYCHIATRY IN CLINICAL PRACTICE
LA English
DT Article
DE Mood disorders; exercise training; sleep quality; body image
   dissatisfaction; cortisol
ID METABOLIC SYNDROME; MAJOR DEPRESSION; PHYSICAL-FITNESS; METAANALYSIS;
   CORTISOL; MEMORY; IMPACT; AXIS
AB Objective: The objective of this study is to assess the impact of an 8-week physical training program on physiological, biological and psychological profiles in individual with mood disorders.Methods: Seven patients participated in the study. Patients were trained twice weekly (75min/session) for 8 weeks. The training program aimed to improve muscular and cardiorespiratory reserves as well as functional capacity. Bioassays were also measured (lipid profile, blood glucose and cortisol). Depression, sleep quality and body image dissatisfaction were assessed. All measures were administrated at pre/post-intervention.Results: At post-intervention, 13 of the 15 physiological fitness, muscular strength and functional capacity variables improved significantly (p<.05). In addition, change in cortisol levels represented a medium to large effect size (Cohen's d=-0.67) which indicates a clinical reduction of stress-related symptoms. Depression was significantly improved (Cohen's d=-0.47; p=.027). Sleep and body image showed a trend-level improvement.Conclusions: An 8-week periodised training program improved physiological, biological and psychological profiles in patients with mood disorders.
C1 [Leone, Mario; Lalande, Daniel; Theriault, Linda] Univ Quebec Chicoutimi, Dept Hlth Sci, Div Kinesiol, Saguenay, PQ, Canada.
   [Kalinova, Emilia] Univ Quebec Montreal, Dept Phys Act Sci, Quebec City, PQ, Canada.
   [Fortin, Audrey] Ctr Hosp Univ Chicoutimi, Saguenay, PQ, Canada.
C3 University of Quebec; University of Quebec Chicoutimi; University of
   Quebec
RP Leone, M (corresponding author), Univ Quebec Chicoutimi, Dept Hlth Sci, Div Kinesiol, 555 Blvd Univ, Chicoutimi, PQ G7N 2B1, Canada.
EM mario.leone@uqac.ca
RI Leone, Mario/R-3874-2019
OI Leone, Mario/0000-0002-1906-7286
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NR 31
TC 5
Z9 6
U1 0
U2 11
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1365-1501
EI 1471-1788
J9 INT J PSYCHIAT CLIN
JI Int. J. Psychiat. Clin.
PY 2018
VL 22
IS 4
BP 268
EP 273
DI 10.1080/13651501.2018.1425458
PG 6
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA HH4QX
UT WOS:000455709200005
PM 29334283
DA 2025-06-11
ER

PT J
AU Ogdie, A
   Schwartzman, S
   Husni, ME
AF Ogdie, Alexis
   Schwartzman, Sergio
   Husni, M. Elaine
TI Recognizing and managing comorbidities in psoriatic arthritis
SO CURRENT OPINION IN RHEUMATOLOGY
LA English
DT Review
DE comorbidity; management; psoriatic arthritis; screening
ID MODIFYING ANTIRHEUMATIC DRUGS; NONSTEROIDAL ANTIINFLAMMATORY DRUGS;
   CARDIOVASCULAR RISK-FACTORS; MINIMAL DISEASE-ACTIVITY; NECROSIS FACTOR
   THERAPY; BONE-MINERAL DENSITY; BODY-MASS INDEX; QUALITY-OF-LIFE;
   RHEUMATOID-ARTHRITIS; AMERICAN-COLLEGE
AB Purpose of review
   Many patients with psoriatic arthritis (PsA) have additional medical problems that can have an impact on morbidity and mortality. The goal of this review is to summarize the available evidence to date on the association of medical comorbidities with PsA and the implications these comorbidities have on prognosis, therapy selection and treatment response.
   Recent findings
   Cardiovascular disease, metabolic syndrome, obesity, diabetes, fatty liver disease Crohn's disease, ophthalmic disease, depression and anxiety are common comorbidities associated with PsA. Additional comorbidities may include an elevated risk for malignancy and osteoporosis; however, fewer studies have addressed these issues and the data available are sometimes conflicting.
   Summary
   All clinicians caring for patients with PsA should be aware of the relevant comorbidities affecting patients with PsA and should have an understanding of how these comorbidities affect management.
C1 [Ogdie, Alexis] Univ Penn, Div Rheumatol, Ctr Clin Epidemiol & Biostat, Ctr Pharmacoepidemiol Res & Training,Perelman Sch, Philadelphia, PA 19104 USA.
   [Schwartzman, Sergio] Hosp Special Surg, New York, NY 10021 USA.
   [Husni, M. Elaine] Cleveland Clin, Cleveland, OH 44106 USA.
C3 University of Pennsylvania; Cleveland Clinic Foundation
RP Ogdie, A (corresponding author), Univ Penn, Div Rheumatol, Ctr Clin Epidemiol & Biostat, Ctr Pharmacoepidemiol Res & Training,Perelman Sch, 8 Penn Tower,1 Convent Ave, Philadelphia, PA 19104 USA.
EM alexis.ogdie@uphs.upenn.edu
RI Schwartzman, Sergio/KMX-4218-2024
OI Ogdie, Alexis/0000-0002-4639-0775
FU NIH [K23AR063764]; Rheumatology Research Foundation; National Psoriasis
   Foundation; Arthritis National Research Foundation
FX No conflicts of interest declared. A.O. is funded by NIH K23AR063764 and
   has received funding from the Rheumatology Research Foundation and
   National Psoriasis Foundation. S.S. has served as a consultant for
   Genentech, UCB, Janssen, Hospira, Abbvie, Pfizer and Crecendo. M.E.H. is
   funded by National Psoriasis Foundation and Arthritis National Research
   Foundation. She also serves on the Steering Committee for GRAPPA.
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NR 117
TC 147
Z9 154
U1 0
U2 9
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1040-8711
EI 1531-6963
J9 CURR OPIN RHEUMATOL
JI Curr. Opin. Rheumatol.
PD MAR
PY 2015
VL 27
IS 2
BP 118
EP 126
DI 10.1097/BOR.0000000000000152
PG 9
WC Rheumatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Rheumatology
GA CA6FW
UT WOS:000349006600005
PM 25603040
DA 2025-06-11
ER

PT J
AU Oghagbon, EK
   Prieto-Pino, J
   Dogoh, F
   Ogiator, M
   Giménez-Llort, L
AF Oghagbon, Efosa K.
   Prieto-Pino, Jose
   Dogoh, Faeren
   Ogiator, Monday
   Gimenez-Llort, Lydia
TI Diabetes/Dementia in Sub-Saharian Africa and Nigerian Women in the Eye
   of Storm
SO CURRENT ALZHEIMER RESEARCH
LA English
DT Review
DE diabetes mellitus; dementia; risk factors; LMIC; Sub-Saharan Africa;
   women; health policies
ID FAMILIAL ALZHEIMER-DISEASE; GLYCATION END-PRODUCTS; METABOLIC SYNDROME;
   DIABETES-MELLITUS; COGNITIVE IMPAIRMENT; DEMENTIA; RISK; PREVALENCE;
   INSULIN; ANEMIA
AB In the next few years, the prevalence of diabetes mellitus (DM) is projected to dramatically increase globally, but most of the cases will occur in low-to-middle-income countries. Some of the major risk factors for diabetes accelerate the development of dementia in African-Americans, thus leading to a higher prevalence of dementia than Caucasians. Sub-Saharian Africa women have a disproportionately two-to-eight fold increased prevalence of dementia. In the eye of this storm, Nigeria holds the highest number of diabetics on the African continent, and its prevalence is rising in parallel to obesity, hypertension, and the population's aging. The socio-economic impact of the rising prevalence of DM and dementia will be huge and unsustainable for the healthcare system in Nigeria, as has been recognized in developed economies. Here, we analyze the current situation of women's health in Nigeria and explore future perspectives and directions. The complex interplay of factors involved in diabetes and dementia in Nigerian women include key biological agents (metabolic syndrome, vascular damage, inflammation, oxidative stress, insulin resistance), nutritional habits, lifestyle, and anemia, that worsen with comorbidities. In addition, restricted resources, lack of visibility, and poor management result in a painful chain that increases the risk and burden of disease in Nigerian women from youth to old ages. Heath policies to increase the ratio of mental health professionals per number of patients, mostly in rural areas, foment of proactive primary care centers, and interventions targeting adolescents and adult women and other specific mothers-children pairs are strongly required for a sustainable development goal.
C1 [Oghagbon, Efosa K.] Benue State Univ, Fac Basic & Allied Med Sci, Dept Chem Pathol, Coll Hlth Sci, Makurdi, Nigeria.
   [Oghagbon, Efosa K.; Dogoh, Faeren] Benue State Univ, Dept Chem Pathol, Teaching Hosp, Makurdi, Nigeria.
   [Prieto-Pino, Jose; Gimenez-Llort, Lydia] Univ Autonoma Barcelona, Dept Psychiat & Forens Med, Fac Med, POB 08193 Cerdanyola Valles, Barcelona, Spain.
   [Prieto-Pino, Jose; Gimenez-Llort, Lydia] Univ Autonoma Barcelona, Inst Neuroci, Barcelona, Spain.
   [Ogiator, Monday] Benue State Univ, Dept Internal Med, Teaching Hosp, Makurdi, Nigeria.
C3 Benue State University; Benue State University; Autonomous University of
   Barcelona; University of Barcelona; Autonomous University of Barcelona;
   Benue State University
RP Giménez-Llort, L (corresponding author), Univ Autonoma Barcelona, Dept Psychiat & Forens Med, Fac Med, POB 08193 Cerdanyola Valles, Barcelona, Spain.
EM lidia.gimenez@uab.cat
RI Giménez-Llort, Lydia/I-3347-2015; Oghagbon, Efosa/E-1184-2012; Pino
   Ortega, Jose/M-7581-2017
OI Gimenez-Llort, Lydia/0000-0002-4091-489X; Pino Ortega,
   Jose/0000-0002-9091-0897
FU Memorial Mercedes Llort Sender [2021/80/2021/80/092421.3]; Ministry for
   Education
FX The present work is supported by personal funds and Memorial Mercedes
   Llort Sender 2021/80/2021/80/092421.3 for the continuation of the
   project "Prevalence of Cognitive Impairment in Nigerian Subjects with
   Diabetes Mellitus Type 2 and Associated Comorbidities" PI L.G.-L, and
   E.K.O as the counterpart in Nigeria. J.P-P received a Department of
   Psychiatry and Forensic Medicine collaboration grant offered by the
   Ministry for Education.
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NR 80
TC 2
Z9 2
U1 0
U2 7
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1567-2050
EI 1875-5828
J9 CURR ALZHEIMER RES
JI Curr. Alzheimer Res.
PY 2022
VL 19
IS 2
BP 161
EP 170
DI 10.2174/1567205018666211116093747
PG 10
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 2O9NA
UT WOS:000819375700006
PM 34784865
DA 2025-06-11
ER

PT J
AU Hurrle, S
   Hsu, WH
AF Hurrle, Samantha
   Hsu, Walter H.
TI The etiology of oxidative stress in insulin resistance
SO BIOMEDICAL JOURNAL
LA English
DT Review
DE Insulin resistance; Oxidative stress; Type 2 diabetes; Obesity;
   Antioxidants; Adipokines
ID MITOCHONDRIAL DYSFUNCTION; METABOLIC SYNDROME; SUPPLEMENTATION;
   ADIPONECTIN; SENSITIVITY; GLUCOSE; OBESITY; DYSLIPIDEMIA; INFLAMMATION;
   PEOPLE
AB Insulin resistance is a prevalent syndrome in developed as well as developing countries. It is the predisposing factor for type 2 diabetes mellitus, the most common end stage development of metabolic syndrome in the United States. Previously, studies investigating type 2 diabetes have focused on beta cell dysfunction in the pancreas and insulin resistance, and developing ways to correct these dysfunctions. However, in recent years, there has been a profound interest in the role that oxidative stress in the peripheral tissues plays to induce insulin resistance. The objective of this review is to focus on the mechanism of oxidative species generation and its direct correlation to insulin resistance, to discuss the role of obesity in the pathophysiology of this phenomenon, and to explore the potential of antioxidants as treatments for metabolic dysfunction.
C1 [Hurrle, Samantha; Hsu, Walter H.] Iowa State Univ, Dept Biomed Sci, Ames, IA 50011 USA.
C3 Iowa State University
RP Hsu, WH (corresponding author), Iowa State Univ, Dept Biomed Sci, Ames, IA 50011 USA.
EM whsu@iastate.edu
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NR 57
TC 328
Z9 353
U1 8
U2 61
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2319-4170
EI 2320-2890
J9 BIOMED J
JI Biomed. J.
PD OCT
PY 2017
VL 40
IS 5
BP 257
EP 262
DI 10.1016/j.bj.2017.06.007
PG 6
WC Biochemistry & Molecular Biology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Research & Experimental Medicine
GA FN8LY
UT WOS:000416277800003
PM 29179880
OA gold, Green Published
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Holsen, LM
   Huang, G
   Cherkerzian, S
   Aroner, S
   Loucks, EB
   Buka, S
   Handa, RJ
   Goldstein, JM
AF Holsen, Laura M.
   Huang, Grace
   Cherkerzian, Sara
   Aroner, Sarah
   Loucks, Eric B.
   Buka, Steve
   Handa, Robert J.
   Goldstein, Jill M.
TI Sex Differences in Hemoglobin A1c Levels Related to the Comorbidity of
   Obesity and Depression
SO JOURNAL OF WOMENS HEALTH
LA English
DT Article
DE diabetes; epidemiology; mental health; obesity; long-term weight
ID C-REACTIVE PROTEIN; CARDIOVASCULAR-DISEASE; MAJOR DEPRESSION;
   RISK-FACTORS; SYMPTOMS; DISORDER; ASSOCIATION; EPIDEMIOLOGY; HEALTHY;
   GENDER
AB Background: Obesity (OB) and major depressive disorder (MDD) are chronic conditions associated with disease burden, and their comorbidity appears more common among women. Mechanisms linking these conditions may involve inflammatory and metabolic pathways. The goal of this study was to evaluate the impact of MDD on relationships between OB and cardiometabolic function, and sex differences therein.
   Materials and Methods: Adult offspring from the New England Family Studies (NEFS) were assessed at ages 39-50, including anthropometry, cardiometabolic profile assays, and metabolic syndrome. Individuals were grouped by body mass index (BMI) and MDD status: healthy weight with (n = 50) or without MDD (n = 95) and obese with (n = 79) or without MDD (n = 131). The interaction of (recurrent) MDD and BMI on cardiometabolic markers was tested using quantile regression models.
   Results: Participants with MDD exhibited significantly higher hemoglobin A1c (HbA1c) than those without MDD (5.60% vs. 5.35%, p < 0.05). Women with comorbid recurrent MDD and OB had higher HbA1c levels compared to obese women without MDD (5.75% vs. 5.44%, p < 0.05); an interaction between MDD and BMI status was not observed among men.
   Conclusions: We demonstrated sex differences in the interaction between BMI and recurrent MDD status on a primary biomarker for diabetes risk, suggesting a common metabolic pathway predisposing women to these comorbid conditions. Further investigation is needed to identify mechanisms that may lead to more effective, sex-dependent screening and therapies.
C1 [Holsen, Laura M.; Goldstein, Jill M.] Dept Med, Div Womens Hlth, BC-3,1620 Tremont St, Boston, MA 02120 USA.
   [Holsen, Laura M.] Dept Psychiat, Boston, MA USA.
   [Holsen, Laura M.; Huang, Grace; Cherkerzian, Sara; Goldstein, Jill M.] Harvard Med Sch, Boston, MA 02115 USA.
   [Huang, Grace] Dept Med, Div Endocrinol Diabet & Hypertens, Boston, MA USA.
   [Cherkerzian, Sara] Brigham & Womens Hosp, Dept Pediat Newborn Med, 75 Francis St, Boston, MA 02115 USA.
   [Aroner, Sarah; Goldstein, Jill M.] Massachusetts Gen Hosp, Dept Psychiat, Boston, MA 02114 USA.
   [Loucks, Eric B.; Buka, Steve] Brown Univ, Dept Epidemiol, Sch Publ Hlth, Providence, RI 02912 USA.
   [Handa, Robert J.] Colorado State Univ, Coll Vet Med & Biomed Sci, Dept Biomed Sci, Ft Collins, CO 80523 USA.
   [Handa, Robert J.] Univ Arizona, Coll Med, Dept Basic Med Sci, Phoenix, AZ USA.
   [Goldstein, Jill M.] Massachusetts Gen Hosp, Dept Obstet & Gynecol, Boston, MA 02114 USA.
C3 Harvard University; Harvard Medical School; Harvard University; Harvard
   University Medical Affiliates; Brigham & Women's Hospital; Harvard
   University; Harvard University Medical Affiliates; Massachusetts General
   Hospital; Brown University; Colorado State University System; Colorado
   State University Fort Collins; University of Arizona; Harvard
   University; Harvard University Medical Affiliates; Massachusetts General
   Hospital
RP Holsen, LM (corresponding author), Dept Med, Div Womens Hlth, BC-3,1620 Tremont St, Boston, MA 02120 USA.
EM lholsen@bwh.harvard.edu
RI Loucks, Eric/I-1272-2014; Cherkerzian, Sara/MHQ-2272-2025; Holsen,
   Laura/I-9186-2014
FU State of Arizona Arizona Biomedical Research Commission (ABRC)
   [ADHS1400003606]; National Institutes of Health [R01MH074679,
   R01AG023397, K08HL132122]
FX This study was supported by the State of Arizona Arizona Biomedical
   Research Commission (ABRC) ADHS1400003606 (Handa & Goldstein, multi-PIs)
   and the National Institutes of Health (R01MH074679 (Goldstein, PI),
   RC2AG036666 EL, SB, MPIs, R01AG023397 (Goldstein, PI), and K08HL132122,
   Huang, PI).
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NR 48
TC 2
Z9 2
U1 0
U2 5
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-9996
EI 1931-843X
J9 J WOMENS HEALTH
JI J. Womens Health
PD SEP 1
PY 2021
VL 30
IS 9
BP 1303
EP 1312
DI 10.1089/jwh.2020.8467
EA FEB 2021
PG 10
WC Public, Environmental & Occupational Health; Medicine, General &
   Internal; Obstetrics & Gynecology; Women's Studies
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; General & Internal
   Medicine; Obstetrics & Gynecology; Women's Studies
GA UQ4FN
UT WOS:000616286400001
PM 33534642
OA Green Published
DA 2025-06-11
ER

PT J
AU Paquette, M
   Larqué, ASM
   Weisnagel, SJ
   Desjardins, Y
   Marois, J
   Pilon, G
   Dudonné, S
   Marette, A
   Jacques, H
AF Paquette, Martine
   Larque, Ana S. Medina
   Weisnagel, S. J.
   Desjardins, Yves
   Marois, Julie
   Pilon, Genevieve
   Dudonne, Stephanie
   Marette, Andre
   Jacques, Helene
TI Strawberry and cranberry polyphenols improve insulin sensitivity in
   insulin-resistant, non-diabetic adults: a parallel, double-blind,
   controlled and randomised clinical trial
SO BRITISH JOURNAL OF NUTRITION
LA English
DT Article
DE Polyphenols; Strawberries; Cranberries; Insulin sensitivity; Glucose
   metabolism; Insulin secretion; Insulin-resistant subjects
ID PLASMA ANTIOXIDANT CAPACITY; ACTIVATED PROTEIN-KINASE; C-REACTIVE
   PROTEIN; METABOLIC SYNDROME; JUICE CONSUMPTION; BLOOD-PRESSURE;
   POSTMENOPAUSAL WOMEN; PHENOLIC-COMPOUNDS; OXIDATIVE STRESS; GUT
   MICROBIOTA
AB Plant-derived foods rich in polyphenols are associated with several cardiometabolic health benefits, such as reduced postprandial hyperglycaemia. However, their impact on whole-body insulin sensitivity using the hyperinsulinaemic-euglycaemic clamp technique remains under-studied. We aimed to determine the effects of strawberry and cranberry polyphenols (SCP) on insulin sensitivity, glucose tolerance, insulin secretion, lipid profile, inflammation and oxidative stress markers in free-living insulin-resistant overweight or obese human subjects (n 41) in a parallel, double-blind, controlled and randomised clinical trial. The experimental group consumed an SCP beverage (333 mg SCP) daily for 6 weeks, whereas the Control group received a flavour-matched Control beverage that contained 0 mg SCP. At the beginning and at the end of the experimental period, insulin sensitivity was assessed by a hyperinsulinaemic-euglycaemic clamp, and glucose tolerance and insulin secretion by a 2-h oral glucose tolerance test (OGTT). Insulin sensitivity increased in the SCP group as compared with the Control group (+ 0.9 ((SEM) 0.5) x 10(-3) v. -0.5 ((SEM) 0.5) x 10(-3) mg/kg per min per pmol, respectively, P = 0.03). Compared with the Control group, the SCP group had a lower first-phase insulin secretion response as measured by C-peptide levels during the first 30 min of the OGTT (P = 0.002). No differences were detected between the two groups for lipids and markers of inflammation and oxidative stress. A 6-week dietary intervention with 333 mg of polyphenols from strawberries and cranberries improved insulin sensitivity in overweight and obese non-diabetic, insulin-resistant human subjects but was not effective in improving other cardiometabolic risk factors.
C1 [Paquette, Martine; Larque, Ana S. Medina; Desjardins, Yves; Marois, Julie; Pilon, Genevieve; Dudonne, Stephanie; Marette, Andre; Jacques, Helene] Laval Univ, Inst Nutr & Funct Foods, Quebec City, PQ G1V 0A6, Canada.
   [Paquette, Martine; Larque, Ana S. Medina; Weisnagel, S. J.; Marois, Julie; Jacques, Helene] Laval Univ, Sch Nutr, Quebec City, PQ G1V 0A6, Canada.
   [Weisnagel, S. J.] Laval Univ, Hlth Ctr Quebec, Endocrinol & Nephrol Axis, Diabet Res Unit,Res Ctr, Quebec City, PQ G1V 4G2, Canada.
   [Pilon, Genevieve; Marette, Andre] Quebec Heart & Lung Inst, Quebec City, PQ G1V 4G5, Canada.
C3 Laval University; Laval University; Laval University; Quebec Heart &
   Lung Institute
RP Jacques, H (corresponding author), Laval Univ, Inst Nutr & Funct Foods, Quebec City, PQ G1V 0A6, Canada.; Jacques, H (corresponding author), Laval Univ, Sch Nutr, Quebec City, PQ G1V 0A6, Canada.
EM helene.jacques@fsaa.ulaval.ca
RI Marette, Andre/E-9342-2013; Desjardins, Yves/F-1222-2013
OI Jacques, Helene/0000-0002-2755-6346; Marette, Andre/0000-0003-3950-5973;
   Dudonne, Stephanie/0000-0001-6581-4070; Desjardins,
   Yves/0000-0002-0398-2797
FU Jean-Paul-Houle Funds; Diabete Quebec; INAF; Consortium de recherche et
   innovations en bioprocedes industriels au Quebec; Atrium Innovations
   Inc.; Nutra Canada
FX The authors are grateful to Marie-Christine Dube, Louise Rheaume,
   Valerie-Eve Julien, Marie Tremblay and Camille Lambert, from the
   Diabetes Research Unit (Laval University Health Center of Quebec) who
   helped in performing hyperinsulinaemic-euglycaemic clamps and Steeve
   Larouche and Danielle Aubin, the nurses who performed OGTT (INAF, Laval
   University). The authors also thank Helene Crepeau from Laval
   University, for help with statistical analysis and the subjects who
   participated in this study. Finally, the authors acknowledge
   Jean-Paul-Houle Funds, Diabete Quebec and INAF for scholarships. The
   present study was supported by the Consortium de recherche et
   innovations en bioprocedes industriels au Quebec, Atrium Innovations
   Inc. and Nutra Canada. Parts of this study were presented in abstract
   form at the 17th Annual Canadian Diabetes Association/Canadian Society
   of Endocrinology and Metabolism (CDA/CSEM) Professional Conference &
   Annual Meetings, Winnipeg, Manitoba, Canada, 22-25 October 2014.
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NR 56
TC 110
Z9 116
U1 6
U2 49
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1145
EI 1475-2662
J9 BRIT J NUTR
JI Br. J. Nutr.
PD FEB
PY 2017
VL 117
IS 4
BP 519
EP 531
DI 10.1017/S0007114517000393
PG 13
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA ES2DR
UT WOS:000399336800005
PM 28290272
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Matovic, S
   Rummel, C
   Neumann, E
   Mcgrath, J
   Gouin, JP
AF Matovic, Sara
   Rummel, Christoph
   Neumann, Elena
   Mcgrath, Jennifer
   Gouin, Jean-Philippe
TI Adverse Childhood Experiences Influence Longitudinal Changes in Leptin
   But Not Adiponectin
SO BIOPSYCHOSOCIAL SCIENCE AND MEDICINE
LA English
DT Article
DE adverse childhood experiences; adipokines; obesity; cardiometabolic
   health
ID BODY-MASS INDEX; ADIPOSE-TISSUE; SERUM LEPTIN; LIFE STRESS; OBESITY;
   ADULTS; RATIO; RESISTANCE; ABUSE; SENSITIZATION
AB Objective Adverse childhood experiences (ACEs) are associated with a greater risk of obesity and cardiometabolic disease. Adipokines, including leptin and adiponectin, play vital roles in biological processes linked to obesity and cardiometabolic risk. The adiponectin/leptin ratio may represent a marker of impaired hormonal regulation of adipose tissue. Prior cross-sectional studies suggest patterns of higher plasma leptin and lower adiponectin among adults who have experienced ACEs. This study addresses whether ACEs influence longitudinal changes in leptin, adiponectin, and the adiponectin/leptin ratio, after accounting for current chronic stress and adiposity. Methods This longitudinal study included 192 middle-aged mothers (mean age = 46.78 years) experiencing higher (n = 108) and lower (n = 84) chronic caregiving stress. Adipokines and adiposity were measured at three timepoints: T1 (baseline), T2 (15 months later), and T3 (30 months after T1). ACEs were assessed retrospectively using the Childhood Trauma Questionnaire. Results Mixed-effect models showed that leptin and adiponectin increased over time. Greater ACEs exposure was associated with larger increases in leptin over time, but it was not related to adiponectin or the adiponectin/leptin ratio. Current caregiving stress was not related to leptin and adiponectin levels and did not interact with ACEs in predicting adipokine levels. Mediation analyses revealed that increases in waist circumference partially mediated the association between ACEs and increases in leptin over time. Conclusions ACEs may increase vulnerability to cardiometabolic risk in midlife caregiving mothers through its influence on longitudinal changes in leptin and central adiposity.
C1 [Matovic, Sara; Mcgrath, Jennifer; Gouin, Jean-Philippe] Concordia Univ, Montreal, PQ, Canada.
   [Rummel, Christoph] Justus Liebig Univ Giessen, Inst Vet Physiol & Biochem, Giessen, Germany.
   [Rummel, Christoph; Neumann, Elena] Univ Marburg, Ctr Mind Brain & Behav CMMB, Marburg, Germany.
   [Rummel, Christoph; Neumann, Elena] Justus Liebig Univ Giessen, Giessen, Germany.
   [Neumann, Elena] Justus Liebig Univ Giessen, Dept Rheumatol & Clin Immunol, Campus Kerckhoff, Bad Nauheim, Germany.
C3 Concordia University - Canada; Justus Liebig University Giessen;
   Philipps University Marburg; Justus Liebig University Giessen; Justus
   Liebig University Giessen
RP Gouin, JP (corresponding author), 7141 Sherbrooke St W, Montreal, PQ H4B 1R6, Canada.
EM saramatovic7@gmail.com; Christoph.D.Rummel@vetmed.uni-giessen.de;
   e.neumann@kerckhoff-klinik.de; Jennifer.McGrath@concordia.ca;
   JP.Gouin@concordia.ca
OI McGrath, Jennifer/0000-0003-1999-5047; Neumann,
   Elena/0000-0001-7609-5964; Rummel, Christoph/0000-0001-5457-4390; Gouin,
   Jean-Philippe/0000-0002-5497-5140
FU Canadian Institute of Health Research (CIHR); EU Joint
   Programme-Neurodegenerative Disease Re-search (JPND) [SOLID
   JPND2021-650-233]; Federal Ministry of Education and Research
   [01EC1903B]; Vanier Canada Graduate Scholarship - Social Sciences and
   Humanities Research Council (SSHRC)
FX Source of Funding and Conflicts of Interest: This study was supported by
   a project grant from the Canadian Institute of Health Research (CIHR).
   Moreover, this research was partially supported by the EU Joint
   Programme-Neurodegenerative Disease Re-search (JPND), grant number SOLID
   JPND2021-650-233, and by the Federal Ministry of Education and Research,
   grant number 01ED2207. The research was partially funded by the Federal
   Ministry of Education and Research, grant number 01EC1903B. Sara Matovic
   is the recipient of a Vanier Canada Graduate Scholarship funded by the
   Social Sciences and Humanities Research Council (SSHRC). There is no
   conflict of interest associated with the publication of this article.
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NR 83
TC 0
Z9 0
U1 2
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 2998-8748
EI 2998-8756
J9 BIOPSYCH SCI MED
JI Biopsychosoc. Sci. Med.
PD FEB-MAR
PY 2025
VL 87
IS 2
BP 118
EP 128
DI 10.1097/PSY.0000000000001366
PG 11
WC Psychiatry; Psychology; Psychology, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry; Psychology
GA W1I4W
UT WOS:001416196800002
PM 39909010
DA 2025-06-11
ER

PT J
AU Fuller, NR
   Sainsbury, A
   Caterson, ID
   Denyer, G
   Fong, M
   Gerofi, J
   Leung, C
   Lau, NS
   Williams, KH
   Januszewski, AS
   Jenkins, AJ
   Markovic, TP
AF Fuller, Nicholas R.
   Sainsbury, Amanda
   Caterson, Ian D.
   Denyer, Gareth
   Fong, Mackenzie
   Gerofi, James
   Leung, Chloris
   Lau, Namson S.
   Williams, Kathryn H.
   Januszewski, Andrzej S.
   Jenkins, Alicia J.
   Markovic, Tania P.
TI Effect of a high-egg diet on cardiometabolic risk factors in people with
   type 2 diabetes: the Diabetes and Egg (DIABEGG) Study-randomized
   weight-loss and follow-up phase
SO AMERICAN JOURNAL OF CLINICAL NUTRITION
LA English
DT Article
DE diabetes; nutrition; obesity; overweight; prediabetes
ID CORONARY-HEART-DISEASE; CARDIOVASCULAR-DISEASE; PLASMA HOMOCYSTEINE;
   METABOLIC SYNDROME; CONTROLLED-TRIAL; MYOCARDIAL-INFARCTION;
   SERUM-CHOLESTEROL; PHYSICAL-ACTIVITY; HDL CHOLESTEROL; CONSUMPTION
AB Background: Some country guidelines recommend that people with type 2 diabetes (T2D) limit their consumption of eggs and cholesterol. Our previously published 3-mo weight-maintenance study showed that a high-egg (>= 12 eggs/wk) diet compared with a low-egg diet (<2 eggs/wk) did not have adverse effects on cardiometabolic risk factors in adults with T2D.
   Objective: The current study follows the previously published 3-mo weight-maintenance study and assessed the effects of the high-egg compared with the low-egg diets as part of a 3-mo weight-loss period, followed by a 6-mo follow-up period for a total duration of 12 mo.
   Design: Participants with prediabetes or T2D (n = 128) were prescribed a 3-mo daily energy restriction of 2.1 MJ and a macronutrient-matched diet and instructed on specific types and quantities of foods to be consumed, with an emphasis on replacing saturated fats with monounsaturated and polyunsaturated fats. Participants were followed up at the 9- and 12-mo visits.
   Results: From 3 to 12 mo, the weight loss was similar (high-egg compared with low-egg diets: -3.1 +/- 6.3 compared with -3.1 +/- 5.2 kg; P = 0.48). There were no differences between groups in glycemia (plasma glucose, glycated hemoglobin, 1,5-anhydroglucitol), traditional serum lipids, markers of inflammation (high-sensitivity C-reactive protein, interleukin 6, soluble E-selectin), oxidative stress (F2-isoprostanes), or adiponectin from 3 to 12 mo or from 0 to 12 mo.
   Conclusions: People with prediabetes or T2D who consumed a 3-mo high-egg weight-loss diet with a 6-mo follow-up exhibited no adverse changes in cardiometabolic markers compared with those who consumed a low-egg weight-loss diet. A healthy diet based on population guidelines and including more eggs than currently recommended by some countries may be safely consumed. This trial is registered at http://www.anzctr.org.au/ as ACTRN12612001266853. Am J Clin Nutr 2018;107:921-931.
C1 [Fuller, Nicholas R.; Sainsbury, Amanda; Caterson, Ian D.; Denyer, Gareth; Fong, Mackenzie; Gerofi, James; Leung, Chloris; Lau, Namson S.; Williams, Kathryn H.; Markovic, Tania P.] Univ Sydney, Charles Perkins Ctr, Sydney Med Sch, Boden Inst, Sydney, NSW, Australia.
   [Denyer, Gareth] Univ Sydney, Sch Mol Biosci, Sydney, NSW, Australia.
   [Januszewski, Andrzej S.; Jenkins, Alicia J.] Univ Sydney, Natl Hlth & Med Res Council, Clin Trials Ctr, Sydney, NSW, Australia.
   [Caterson, Ian D.; Markovic, Tania P.] Royal Prince Alfred Hosp, Metab & Obes Serv, Camperdown, NSW, Australia.
C3 University of Sydney; University of Sydney; University of Sydney; NSW
   Health; Royal Prince Alfred Hospital; University of Sydney
RP Fuller, NR (corresponding author), Univ Sydney, Charles Perkins Ctr, Sydney Med Sch, Boden Inst, Sydney, NSW, Australia.
EM nick.fuller@sydney.edu.au
RI Denyer, Gareth/M-5417-2016; Markovic, Tania/ABC-5205-2020; Salis,
   Amanda/A-3187-2011; Januszewski, Andrzej/R-4299-2019; Jenkins,
   Alicia/N-2482-2015
OI Fong, Mackenzie/0000-0001-7237-9038; Salis, Amanda/0000-0001-9176-1574;
   Jenkins, Alicia/0000-0003-0583-3717; Markovic,
   Tania/0000-0003-2521-0357; Lau, Namson/0000-0002-9400-8470
FU Australian Egg Corporation; National Health and Medical Research Council
   (NHMRC) of Australia [1042555]; Sydney Medical School Foundation
FX Supported by a research grant from the Australian Egg Corporation. AS
   was supported by a research fellowship from the National Health and
   Medical Research Council (NHMRC) of Australia (1042555). AJJ has
   received an NHMRC Practitioner Fellowship and a fellowship from the
   Sydney Medical School Foundation.
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NR 62
TC 33
Z9 37
U1 1
U2 19
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0002-9165
EI 1938-3207
J9 AM J CLIN NUTR
JI Am. J. Clin. Nutr.
PD JUN
PY 2018
VL 107
IS 6
BP 921
EP 931
DI 10.1093/ajcn/nqy048
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA GJ5YJ
UT WOS:000435459400010
PM 29741558
OA Bronze
DA 2025-06-11
ER

PT J
AU Tucker, P
   Marquié, JC
   Folkard, S
   Ansiau, D
   Esquirol, Y
AF Tucker, Philip
   Marquie, Jean-Claude
   Folkard, Simon
   Ansiau, David
   Esquirol, Yolande
TI Shiftwork and Metabolic Dysfunction
SO CHRONOBIOLOGY INTERNATIONAL
LA English
DT Article; Proceedings Paper
CT 20th International Symposium on Shift Work and Working Time
CY JUN 28-JUL 01, 2011
CL Stockholm, SWEDEN
DE Health; Metabolic syndrome; Shiftwork; Sleep; Stress
ID CARDIOVASCULAR-DISEASE; POSTPRANDIAL HORMONE; WORK-ENVIRONMENT;
   RISK-FACTORS; SLEEP; RESPONSES; STRESS; HEALTH; ASSOCIATION; DURATION
AB Many of the health problems that are more prevalent among shiftworkers are thought to be linked to their heightened susceptibility to metabolic syndrome, i.e., the association of even moderate degrees of visceral obesity, dyslipidemia, abnormal blood pressure, and serum glucose levels in the same individual. Although previous studies have identified associations between shiftwork and metabolic syndrome, there is relatively little evidence to date of how the risk of developing it varies as a function of exposure to shiftwork. The current study seeks to confirm earlier findings of an association between shiftwork exposure and metabolic dysfunction, and to examine the impact of exposure duration, while adjusting for a number of covariates in the analyses. The analyses were based on data from VISAT, a study involving the measurement of physiological, behavioral, and subjective outcomes from 1757 participants, 989 being current or former shiftworkers. The sample comprised employed and retired wage earners, male and female, who were 32, 42, 52, and 62 yrs old. The first analysis sought to confirm previous findings of an association between exposure to shiftwork and the risk of developing metabolic syndrome. It indicated that participants who were or who had previously been shiftworkers (i.e., working schedules that involved rotating shifts; not being able to go to bed before midnight; having to get up before 05:00 h; or being prevented from sleeping during the night) were more likely to exhibit symptoms of metabolic syndrome, after adjusting for age, sex, socioeconomic status, smoking, alcohol intake, perceived stress, and sleep difficulty (odds ratio [OR] 1.78; 95% confidence interval [CI] 1.03-3.08). The results suggest the association between shiftwork and metabolic syndrome cannot be fully accounted for by either higher levels of strain or increased sleep difficulty among shiftworkers, although it remains a possibility that either one or both of these factors may have played a contributing role. The second analysis addressed the issue of duration of exposure to shiftwork. Participants with >10 yrs' experience of working rotating shifts were more likely to exhibit symptoms of metabolic syndrome than participants without exposure to shiftwork, i.e., dayworkers, even after adjusting for age and sex (OR 1.96; 95% CI 1.03-3.75). Thus, the current study confirms the association between shiftwork exposure and metabolic syndrome. It also provides new information regarding the time course of the development of the illness as function of exposure duration, although this was only examined in relation to rotating shiftwork. It is concluded that those responsible for monitoring workers' health should pay particular attention to indices of metabolic dysfunction in workers who have been exposed to shiftwork for >10 yrs. (Author correspondence: p.t.tucker@swansea.ac.uk)
C1 [Tucker, Philip; Folkard, Simon] Swansea Univ, Dept Psychol, Swansea SA2 8PP, W Glam, Wales.
   [Tucker, Philip] Stockholm Univ, Stress Res Inst, S-10691 Stockholm, Sweden.
   [Marquie, Jean-Claude] Univ Toulouse 2, Toulouse, France.
   [Folkard, Simon] Univ Paris 05, Paris, France.
   [Esquirol, Yolande] Univ Toulouse 3, UMR 1027, F-31062 Toulouse, France.
C3 Swansea University; Stockholm University; Universite de Toulouse;
   Universite de Toulouse - Jean Jaures; Universite Paris Cite; Universite
   de Toulouse; Universite Toulouse III - Paul Sabatier; Institut National
   de la Sante et de la Recherche Medicale (Inserm)
RP Tucker, P (corresponding author), Swansea Univ, Dept Psychol, Swansea SA2 8PP, W Glam, Wales.
EM p.t.tucker@swansea.ac.uk
RI Esquirol, yolande/KEE-9367-2024; Esquirol, Yolande/E-4177-2017
OI Tucker, Philip/0000-0002-8105-0901; Esquirol,
   Yolande/0000-0002-2235-0330
CR [Anonymous], 2006, IDF CONS WORLDW DEF
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NR 42
TC 41
Z9 50
U1 0
U2 25
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 0742-0528
J9 CHRONOBIOL INT
JI Chronobiol. Int.
PY 2012
VL 29
IS 5
BP 549
EP 555
DI 10.3109/07420528.2012.675259
PG 7
WC Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Life Sciences & Biomedicine - Other Topics; Physiology
GA 946MU
UT WOS:000304356800003
PM 22621350
DA 2025-06-11
ER

PT J
AU Lu, YC
   Sudirman, S
   Mao, CF
   Kong, ZL
AF Lu, Yi-Cheng
   Sudirman, Sabri
   Mao, Chien-Feng
   Kong, Zwe-Ling
TI Glycoprotein from Mytilus edulis extract inhibits lipid
   accumulation and improves male reproductive dysfunction in high-fat
   diet-induced obese rats
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Article
DE Glycoprotein; High-fat diet; Male reproduction; Mytilus edulis; Obesity
ID ANTI-ADIPOGENIC ACTIVITY; 3T3-L1 PREADIPOCYTES; SEXUAL DYSFUNCTION;
   METABOLIC SYNDROME; OXIDATIVE STRESS; TESTOSTERONE; DIFFERENTIATION;
   ADIPONECTIN; ACID
C1 [Lu, Yi-Cheng; Sudirman, Sabri; Mao, Chien-Feng; Kong, Zwe-Ling] Natl Taiwan Ocean Univ, Dept Food Sci, 2 Peining Rd, Keelung 20224, Taiwan.
C3 National Taiwan Ocean University
RP Kong, ZL (corresponding author), Natl Taiwan Ocean Univ, Dept Food Sci, 2 Peining Rd, Keelung 20224, Taiwan.
EM cutes5566@gmail.com; sabrisudirman@unsri.ac.id; jjonujmrt@gmail.com;
   kongzl@mail.ntou.edu.tw
RI Kong, Zwe-Ling/AAB-5328-2019; Kong, Zwe-Ling/E-8763-2013; Sudirman,
   Sabri/O-2980-2018
OI MAO, CHIEN-FENG/0000-0001-7083-7293; Kong, Zwe-Ling/0000-0002-4877-6524;
   Sudirman, Sabri/0000-0003-2821-3772
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NR 46
TC 11
Z9 11
U1 0
U2 9
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD JAN
PY 2019
VL 109
BP 369
EP 376
DI 10.1016/j.biopha.2018.10.180
PG 8
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA HD5AE
UT WOS:000452539100040
PM 30399571
OA gold
DA 2025-06-11
ER

PT J
AU Silvestrini, A
   Meucci, E
   Ricerca, BM
   Mancini, A
AF Silvestrini, Andrea
   Meucci, Elisabetta
   Ricerca, Bianca Maria
   Mancini, Antonio
TI Total Antioxidant Capacity: Biochemical Aspects and Clinical
   Significance
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE oxidative stress; total antioxidant capacity; obesity; metabolic
   syndrome; redox balance
ID OXIDATIVE STRESS; PLASMA; REDUCTION; SYSTEMS; SEMEN; MECHANISM;
   EXERCISE; DISEASE; BIOLOGY; OBESITY
AB Despite the physiological role of oxidant molecules, oxidative stress (OS) could underlie several human diseases. When the levels of antioxidants are too low or too high, OS occurs, leading to damage at the molecular, tissue and cellular levels. Therefore, antioxidant compounds could represent a way to modulate OS and/or to maintain proper redox balance. This review provides an overview of the methods available to assess total antioxidant capacity (TAC) in biological systems to elucidate the correct terminology and the pathophysiological roles. The clinical context is fundamental to obtain a correct interpretation of TAC. Hence, we discuss metabolic syndrome and infertility, two clinical conditions that involve OS, including the potential prognostic role of TAC evaluation in monitoring antioxidant supplementation. This approach would provide more personalised and precise therapy.
C1 [Silvestrini, Andrea; Meucci, Elisabetta] Univ Cattolica Sacro Cuore, Dipartimento Sci Biotecnolog Base Clin Intensivolo, I-00168 Rome, Italy.
   [Silvestrini, Andrea; Meucci, Elisabetta; Ricerca, Bianca Maria; Mancini, Antonio] Fdn Policlin Univ Agostino Gemelli IRCCS, I-00168 Rome, Italy.
   [Ricerca, Bianca Maria] Univ Cattolica Sacro Cuore, Dipartimento Diagnost Immagini Radioterapia Oncolo, I-00168 Rome, Italy.
   [Mancini, Antonio] Univ Cattolica Sacro Cuore, Dipartimento Med & Chirurg Traslazionale, I-00168 Rome, Italy.
C3 Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli;
   Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli;
   Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli;
   Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli
RP Silvestrini, A (corresponding author), Univ Cattolica Sacro Cuore, Dipartimento Sci Biotecnolog Base Clin Intensivolo, I-00168 Rome, Italy.; Silvestrini, A (corresponding author), Fdn Policlin Univ Agostino Gemelli IRCCS, I-00168 Rome, Italy.
EM andrea.silvestrini@unicatt.it
RI Silvestrini, Andrea/B-3410-2009
OI Silvestrini, Andrea/0000-0002-2005-3746
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NR 73
TC 81
Z9 84
U1 11
U2 36
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD JUL
PY 2023
VL 24
IS 13
AR 10978
DI 10.3390/ijms241310978
PG 12
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA M2LL5
UT WOS:001028547000001
PM 37446156
OA Green Published, gold
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Gyawali, P
   Richards, RS
   Tinley, P
   Nwose, EU
   Bwititi, PT
AF Gyawali, Prajwal
   Richards, Ross S.
   Tinley, Paul
   Nwose, Ezekiel Uba
   Bwititi, Phillip T.
TI Hemorheological parameters better classify metabolic syndrome than novel
   cardiovascular risk factors and peripheral vascular disease marker
SO CLINICAL HEMORHEOLOGY AND MICROCIRCULATION
LA English
DT Article
DE Hemorheology; oxidative stress; inflammation; ROC curve
ID ERYTHROCYTE MORPHOLOGY; INSULIN SENSITIVITY; BLOOD-VISCOSITY; MINIMAL
   MODEL; INFLAMMATION; ASSOCIATION
AB The present study compares the association of Metabolic Syndrome (MetS) with hemorheological parameters, oxidative stress, inflammation and peripheral arterial disease markers. 100 participants were recruited and participants were divided into three groups on the basis of absence or presence of MetS and its components. Odds ratio for correctly predicting MetS was highest for erythrocyte aggregation followed by erythrocyte deformability. ROC curve analysis demonstrated that all the hemorheological components significantly classified MetS participants. Area Under Curve was higher for the hemorheological parameters (erythrocyte aggregation and erythrocyte deformability) than for the oxidative stress, inflammation and peripheral arterial disease markers. The possibilities of the hemorheological components to be identified as better cardiovascular risk markers due to their strong association with MetS cannot be precluded from the present findings.
C1 [Gyawali, Prajwal; Richards, Ross S.] Charles Sturt Univ, Sch Community Hlth, Biomed Sci, Albury, NSW 2640, Australia.
   [Tinley, Paul] Charles Sturt Univ, Podiatry, Bathurst, NSW 2795, Australia.
   [Nwose, Ezekiel Uba] Charles Sturt Univ, Sch Community Hlth, Bathurst, NSW 2795, Australia.
   [Bwititi, Phillip T.] Charles Sturt Univ, Sch Biomed Sci, Bathurst, NSW 2795, Australia.
C3 Charles Sturt University; Charles Sturt University; Charles Sturt
   University; Charles Sturt University
RP Gyawali, P (corresponding author), Charles Sturt Univ, Sch Community Hlth, Biomed Sci, Albury, NSW 2640, Australia.
EM clbioprajwal@gmail.com
RI Bwititi, Phillip/HTP-8025-2023; Nwose, Ezekiel 'Uba'/I-1333-2018
OI Nwose, Ezekiel 'Uba'/0000-0003-1318-9853; Gyawali,
   Prajwal/0000-0003-0975-5576
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NR 16
TC 7
Z9 7
U1 0
U2 1
PU IOS PRESS
PI AMSTERDAM
PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS
SN 1386-0291
EI 1875-8622
J9 CLIN HEMORHEOL MICRO
JI Clin. Hemorheol. Microcirc.
PY 2016
VL 64
IS 1
BP 1
EP 5
DI 10.3233/CH-152033
PG 5
WC Hematology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Hematology; Cardiovascular System & Cardiology
GA EC1WO
UT WOS:000387899700001
PM 26890105
DA 2025-06-11
ER

PT J
AU Amodeo, G
   Cuomo, A
   Bolognesi, S
   Goracci, A
   Trusso, MA
   Piccinni, A
   Neal, SM
   Baldini, I
   Federico, E
   Taddeucci, C
   Fagiolini, A
AF Amodeo, Giovanni
   Cuomo, Alessandro
   Bolognesi, Simone
   Goracci, Arianna
   Trusso, Maria A.
   Piccinni, Armando
   Neal, Stephen M.
   Baldini, Irene
   Federico, Eugenio
   Taddeucci, Costanza
   Fagiolini, Andrea
TI Pharmacotherapeutic strategies for treating binge eating disorder.
   Evidence from clinical trials and implications for clinical practice
SO EXPERT OPINION ON PHARMACOTHERAPY
LA English
DT Review
DE Binge eating disorder; pharmacotherapeutic strategies; treatment;
   lisdexamfetamine; antidepressants; anticonvulsants; obesity agents;
   expert opinion
ID PLACEBO-CONTROLLED TRIAL; COGNITIVE-BEHAVIORAL THERAPY;
   ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; DOUBLE-BLIND; WEIGHT-LOSS;
   OBESE-PATIENTS; OPEN-LABEL; LISDEXAMFETAMINE DIMESYLATE; OVERWEIGHT
   WOMEN; DRUG-THERAPY
AB Introduction: Binge eating disorder (BED) is the most common eating disorder and was newly recognized in 2013 in the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5). BED is frequently associated with obesity and the metabolic syndrome, as well as with other psychiatric diseases, such as mood (49%), anxiety (41%), and substance use (22%) disorders. BED is highly prevalent and carries a high burden of mental and physical illness and disability. However, BED is frequently under-recognized and under-treated.
   Areas covered: This paper reviews the main pharmacological treatments for BED and provides an expert opinion based on the available evidence and on the authors' clinical experience with patients affected by BED.
   Expert opinion: Several medications have proven to be effective for the treatment of BED, including Lisdexamfetamine (LDX), topiramate as well as anti-anxiety and antidepressant medications. To date, LDX is the only FDA approved medication for BED. Consequently, as a general rule, the use of an FDA approved medication should always be preferred. However, when in the presence of concomitant psychiatric conditions such as anxiety or depression, other medications that have proven efficacy in those comorbid conditions can be used and may contextually provide a benefit for BED.
C1 [Amodeo, Giovanni; Cuomo, Alessandro; Bolognesi, Simone; Goracci, Arianna; Trusso, Maria A.; Baldini, Irene; Federico, Eugenio; Taddeucci, Costanza; Fagiolini, Andrea] Univ Siena, Dept Mol & Dev Med, Siena, Italy.
   [Piccinni, Armando] UniCamillus St Camillus Int Univ Hlth Sci, Rome, Italy.
   [Neal, Stephen M.] West Virginia Sch Osteopath Med, Dept Psychiat, Lewisburg, WV USA.
C3 University of Siena
RP Fagiolini, A (corresponding author), Univ Siena, Sch Med, Div Psychiat, Dept Mol Med, I-53100 Siena, Italy.
EM andreafagiolini@gmail.com
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NR 94
TC 15
Z9 15
U1 3
U2 18
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1465-6566
EI 1744-7666
J9 EXPERT OPIN PHARMACO
JI Expert Opin. Pharmacother.
PD APR 13
PY 2019
VL 20
IS 6
BP 679
EP 690
DI 10.1080/14656566.2019.1571041
PG 12
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Pharmacology & Pharmacy
GA HQ4FL
UT WOS:000462365600006
PM 30696303
DA 2025-06-11
ER

PT J
AU Devalaraja, S
   Jain, S
   Yadav, H
AF Devalaraja, Samir
   Jain, Shalini
   Yadav, Hariom
TI Exotic fruits as therapeutic complements for diabetes, obesity and
   metabolic syndrome
SO FOOD RESEARCH INTERNATIONAL
LA English
DT Article
DE Exotic fruits; Diabetes; Obesity; Metabolic syndrome; Antioxidant
ID EUTERPE-OLERACEA MART.; LYCIUM-BARBARUM POLYSACCHARIDE; LITCHI-CHINENSIS
   SONN; FATTY LIVER-DISEASE; POMEGRANATE SEED OIL; AMAZONIAN PALM BERRY;
   OXIDATIVE STRESS; ANTIOXIDANT ACTIVITY; INSULIN-RESISTANCE;
   PSIDIUM-GUAJAVA
AB The prevalence and severity of obesity, type 2-diabetes, and the resultant metabolic syndrome are rapidly increasing. As successful preventive and therapeutic strategies for these life-threatening health ailments often come with adverse side effects, nutritional elements are widely used in many countries as preventive therapies to prevent or manage metabolic syndrome. Fruits are important dietary components, and contain various bioactive constituents. Many of these constituents have been proven to be useful to manage and treat various chronic diseases such as diabetes, obesity, cancer and cardiovascular diseases. Although exotic fruits are understudied throughout the world due to their limited regional presence, many studies reveal their potent ability to ameliorate metabolic derangements and the resultant conditions i.e. diabetes and obesity. The aim of this article is to review the role of exotic fruits and their constituents in the regulation of metabolic functions, which can beneficially alter diabetes and obesity pathophysiology. Published by Elsevier Ltd.
C1 [Yadav, Hariom] NIDDK, Endocrinol & Obes Branch, Clin Res Ctr, NIH, Bethesda, MD 20892 USA.
C3 National Institutes of Health (NIH) - USA; NIH National Institute of
   Diabetes & Digestive & Kidney Diseases (NIDDK)
RP Yadav, H (corresponding author), NIDDK, Endocrinol & Obes Branch, Clin Res Ctr, NIH, Bldg 10, Bethesda, MD 20892 USA.
EM yadavh@mail.nih.gov
RI Yadav, Hariom/I-2455-2018
OI Yadav, Hariom/0000-0003-4504-1597; Jain, Shalini/0000-0001-5200-5928
FU Intramural NIH HHS [Z99 DK999999] Funding Source: Medline
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NR 98
TC 125
Z9 137
U1 3
U2 123
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0963-9969
EI 1873-7145
J9 FOOD RES INT
JI Food Res. Int.
PD AUG
PY 2011
VL 44
IS 7
SI SI
BP 1856
EP 1865
DI 10.1016/j.foodres.2011.04.008
PG 10
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA 805WJ
UT WOS:000293759400019
PM 21857774
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Rafiq, N
   Younossi, ZM
AF Rafiq, Nila
   Younossi, Zobair M.
TI Effects of Weight Loss on Nonalcoholic Fatty Liver Disease
SO SEMINARS IN LIVER DISEASE
LA English
DT Review
DE Nonalcoholic fatty liver disease (NAFLD); nonalcoholic steatohepatitis
   (NASH); weight loss
ID METABOLIC SYNDROME; GASTRIC BYPASS; OVERWEIGHT PATIENTS; HEPATIC
   STEATOSIS; RISK-FACTORS; SURGICAL-TREATMENT; BARIATRIC SURGERY;
   RANDOMIZED-TRIAL; LOW-CARBOHYDRATE; MORBID-OBESITY
AB Nonalcoholic fatty liver disease (NAFLD) is one of the most prevalent liver diseases worldwide, affecting men, women, and children. This is due, in part, to the obesity epidemic, which is associated with increased prevalence of NAFLD. The NAFLD spectrum ranges from simple steatosis to nonalcoholic steatohepatitis (NASH), which is the potentially progressive form. NAFLD is associated with metabolic syndrome and insulin resistance. Treatment recommendations include weight reduction through both diet and physical activity, and weight-loss surgery for extreme obesity. Most medical regimens target components of the metabolic syndrome or oxidative stress associated with the pathogenesis of NASH. These include antiobesity regimens, insulin sensitizers, antihyperlipidemics, and antioxidants. Bariatric surgery is effective for achieving and maintaining weight loss and reversing the complications of metabolic syndrome. On the other hand, the literature lacks well-designed, randomized control trials that assess the efficacy of anti-obesity regimens on histologic and long-term outcomes of NAFLD.
C1 [Rafiq, Nila; Younossi, Zobair M.] Inova Fairfax Hosp, Ctr Liver Dis, Falls Church, VA 22042 USA.
C3 Inova Fairfax Hospital
RP Younossi, ZM (corresponding author), Inova Fairfax Hosp, Ctr Liver Dis, 3300 Gallows Rd, Falls Church, VA 22042 USA.
EM zobair.younossi@inova.org
RI Younossi, Zobair M./JRY-9916-2023
CR [Anonymous], OBESITY ACTION COALI
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NR 51
TC 57
Z9 68
U1 1
U2 9
PU THIEME MEDICAL PUBL INC
PI NEW YORK
PA 333 SEVENTH AVE, NEW YORK, NY 10001 USA
SN 0272-8087
EI 1098-8971
J9 SEMIN LIVER DIS
JI Semin. Liver Dis.
PD NOV
PY 2008
VL 28
IS 4
BP 427
EP 433
DI 10.1055/s-0028-1091986
PG 7
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 370RG
UT WOS:000260779800010
PM 18956298
DA 2025-06-11
ER

PT J
AU Moorthy, M
   Wie, CC
   Mariño, E
   Palanisamy, UD
AF Moorthy, Mohanambal
   Wie, Chong Chun
   Marino, Eliana
   Palanisamy, Uma D.
TI The Prebiotic Potential of Geraniin and Geraniin-Enriched Extract
   against High-Fat-Diet-Induced Metabolic Syndrome in Sprague Dawley Rats
SO ANTIOXIDANTS
LA English
DT Article
DE Nephelium lappaceum L; ellagitannin; metabolic syndrome; gut microbiota;
   prebiotic
ID NEPHELIUM-LAPPACEUM; OXIDATIVE STRESS; MICROBIOTA; ACID
AB Geraniin, an ellagitannin, has ameliorative properties against high-fat diet (HFD)-induced metabolic syndrome. Since geraniin has poor bioavailability, we hypothesised the interaction of this compound with gut microbiota as the main mechanism for improving metabolic aberrations. Male Sprague Dawley rats were divided into normal diet (ND)- and HFD-fed animals and treated with geraniin and an enriched extract of geraniin (GEE). We observed that 5 mg geraniin and 115 mg GEE supplementation significantly attenuated glucose intolerance, lipopolysaccharide-binding protein, total cholesterol, triacylglyceride, and low-density lipoprotein; improved insulin sensitivity; and significantly increased adiponectin and hepatic PPAR alpha expression. Although geraniin and GEE did not significantly alter the gut microbial composition, we found an increment in the relative abundance of a few butyrate producers such as Alloprevotella, Blautia, Lachnospiraceae NK4A136 group, and Clostridium sensu stricto 1. Geraniin and its enriched extract's ability to ameliorate metabolic syndrome parameters while positively affecting the growth of butyrate-producing bacteria suggests its potential prebiotic role.
C1 [Moorthy, Mohanambal; Palanisamy, Uma D.] Monash Univ Malaysia, Jeffrey Cheah Sch Med & Hlth Sci, Jalan Lagoon Selatan, Bandar Sunway 47500, Selangor, Malaysia.
   [Wie, Chong Chun] Monash Univ Malaysia, Sch Pharm, Jalan Lagoon Selatan, Bandar Sunway 47500, Selangor, Malaysia.
   [Marino, Eliana] Monash Univ, Monash Biomed Discovery Inst, Clayton Campus,19 Innovat Walk, Clayton, Vic 3800, Australia.
C3 Monash University; Monash University Malaysia; Monash University; Monash
   University Malaysia; Monash University
RP Palanisamy, UD (corresponding author), Monash Univ Malaysia, Jeffrey Cheah Sch Med & Hlth Sci, Jalan Lagoon Selatan, Bandar Sunway 47500, Selangor, Malaysia.
EM mohanambal.moorthy@monash.edu; chong.chunwie@monash.edu;
   eliana.marino@monash.edu; umadevi.palanisamy@monash.edu
RI Palanisamy, Uma/I-4700-2014; Chong, Chun/ABG-7676-2020; Mariño,
   Eliana/GPK-6544-2022; Moorthy, Mohanambal/GLR-1016-2022; Chong, Chun
   Wie/E-2909-2010; Marino, Eliana/C-5135-2011
OI Chong, Chun Wie/0000-0002-6881-8883; Moorthy,
   Mohanambal/0000-0001-5694-9096; Palanisamy, Uma
   Devi/0000-0002-8615-8241; Marino, Eliana/0000-0001-5371-8778
FU Ministry of Higher Education [FRGS/1/2017/SKK08/MUSM/02/2]; Tropical
   Medicine and Biology (TMB) Platform, Monash University
FX This research was funded by the Ministry of Higher Education,
   FRGS/1/2017/SKK08/MUSM/02/2, and the Tropical Medicine and Biology (TMB)
   Platform, Monash University.
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NR 44
TC 9
Z9 9
U1 2
U2 16
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD APR
PY 2022
VL 11
IS 4
AR 632
DI 10.3390/antiox11040632
PG 16
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA 0S2SI
UT WOS:000786128900001
PM 35453317
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Beigrezaei, S
   Yazdanpanah, Z
   Soltani, S
   Rajaie, SH
   Mohseni-Takalloo, S
   Zohrabi, T
   Kaviani, M
   Forbes, SC
   Baker, JS
   Salehi-Abargouei, A
AF Beigrezaei, Sara
   Yazdanpanah, Zeinab
   Soltani, Sepideh
   Rajaie, Seyede Hamide
   Mohseni-Takalloo, Sahar
   Zohrabi, Tayebeh
   Kaviani, Mojtaba
   Forbes, Scott C.
   Baker, Julien S.
   Salehi-Abargouei, Amin
TI The effects of exercise and low-calorie diets compared with low-calorie
   diets alone on health: a protocol for systematic reviews and
   meta-analyses of controlled clinical trials
SO SYSTEMATIC REVIEWS
LA English
DT Article
DE Diet; Diet plus exercise; Energy intake; Cardiometabolic markers; Mental
   health; Bone health; Systematic review; Meta-analysis
ID CARDIOVASCULAR RISK-FACTORS; TYPE-2 DIABETES-MELLITUS; INDUCED
   WEIGHT-LOSS; QUALITY-OF-LIFE; POSTMENOPAUSAL WOMEN; PHYSICAL-ACTIVITY;
   BODY-COMPOSITION; ABDOMINAL FAT; OBESE ADULTS; OVERWEIGHT
AB Background: Exercise and weight loss diets are two independent non-pharmaceutical strategies used to improve several aspects of body composition and health. We plan to systematically review controlled clinical trials investigating weight loss diets alone compared to weight loss diets in conjunction with exercise on energy intake, body weight, body composition, cardiometabolic risk factors, sex hormones, and mental health.
   Methods and analysis: PubMed/MEDLINE, EMBASE, ISI (Web of Science), Scopus, and Google Scholar will be searched to retrieve potential controlled clinical trials investigating the effects of exercise in conjunction with weight loss diets compared with weight loss diets alone on energy intake, body weight and composition (fat mass, fat-free mass), anthropometrics (waist circumference), cardiometabolic markers, sex hormones [testosterone, estradiol, and sex hormone binding globulin (SHBG)], liver and kidney enzymes (alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma-glutamyl transferase (GGT), uric acid, blood urea nitrogen (BUN), glomerular filtration rate (GFR), quality of life, and depression in adults. The weighted mean difference (WMD) and its corresponding 95% confidence intervals (CIs) will be derived using random effects model. Several subgroup analyses based on follow-up duration, the health status of the participants, the diet used for weight loss, the exercise protocol, participants' sex, and other possible variables will be conducted to explore possible sources of heterogeneity. Publication bias will be explored by inspecting funnel plots and by conducting asymmetry tests. Overall quality of the evidence will be assessed by using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) tool.
   Discussion: We envisage that this systematic review and meta-analysis will provide valuable information regarding the effectiveness of adding exercise to weight loss diets. No primary data is going to be collected; therefore, ethical approval is not required. The resulting manuscripts will be disseminated in peer-reviewed journals and at international and national conferences.
C1 [Beigrezaei, Sara; Yazdanpanah, Zeinab; Rajaie, Seyede Hamide; Mohseni-Takalloo, Sahar; Zohrabi, Tayebeh; Salehi-Abargouei, Amin] Shahid Sadoughi Univ Med Sci, Nutr & Food Secur Res Ctr, Yazd, Iran.
   [Beigrezaei, Sara; Yazdanpanah, Zeinab; Rajaie, Seyede Hamide; Mohseni-Takalloo, Sahar; Zohrabi, Tayebeh; Salehi-Abargouei, Amin] Shahid Sadoughi Univ Med Sci, Sch Publ Hlth, Dept Nutr, Yazd, Iran.
   [Soltani, Sepideh] Shahid Sadoughi Univ Med Sci, Yazd Cardiovasc Res Ctr, Yazd, Iran.
   [Mohseni-Takalloo, Sahar] Bam Univ Med Sci, Sch Med, Bam, Iran.
   [Kaviani, Mojtaba] Acadia Univ, Fac Pure & Appl Sci, Sch Nutr & Dietet, Wolfville, NS, Canada.
   [Forbes, Scott C.] Brandon Univ, Fac Educ, Dept Phys Educ Studies, Brandon, MB, Canada.
   [Baker, Julien S.] Hong Kong Baptist Univ, Dept Sport & Phys Educ, Ctr Hlth & Exercise Sci Res, Kowloon Tong, Hong Kong, Peoples R China.
C3 Shahid Sadoughi University of Medical Sciences; Shahid Sadoughi
   University of Medical Sciences; Shahid Sadoughi University of Medical
   Sciences; Acadia University; Brandon University; Hong Kong Baptist
   University
RP Salehi-Abargouei, A (corresponding author), Shahid Sadoughi Univ Med Sci, Nutr & Food Secur Res Ctr, Yazd, Iran.; Salehi-Abargouei, A (corresponding author), Shahid Sadoughi Univ Med Sci, Sch Publ Hlth, Dept Nutr, Yazd, Iran.
EM abargouei@ssu.ac.in
RI Mohseni, Sahar/HKM-9646-2023; Kaviani, Mojtaba/L-4940-2019; Beigrezaei,
   Sara/AAZ-6682-2020; Soltani, Sepideh/AAH-2679-2020; Salehi-Abargouei,
   Amin/C-9039-2011
OI Soltani, Sepideh/0000-0002-1591-2569; Beigrezaei,
   Sara/0000-0003-3903-9941; Salehi-Abargouei, Amin/0000-0002-7580-6717
FU Research Council of the Nutrition and Food Security Research Center,
   Shahid Sadoughi University of Medical Sciences, Yazd, Iran
FX The present systematic review was supported by the Research Council of
   the Nutrition and Food Security Research Center, Shahid Sadoughi
   University of Medical Sciences, Yazd, Iran.
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NR 49
TC 9
Z9 9
U1 2
U2 20
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 2046-4053
J9 SYST REV-LONDON
JI Syst. Rev.
PD APR 20
PY 2021
VL 10
IS 1
AR 120
DI 10.1186/s13643-021-01669-7
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA RQ7HL
UT WOS:000642585500002
PM 33879240
OA Green Submitted, gold, Green Published
DA 2025-06-11
ER

EF﻿FN Clarivate Analytics Web of Science
VR 1.0
PT J
AU Gregory, S
   Hill, D
   Grey, B
   Ketelbey, W
   Miller, T
   Muniz-Terrera, G
   Ritchie, CW
AF Gregory, Sarah
   Hill, David
   Grey, Ben
   Ketelbey, William
   Miller, Tamara
   Muniz-Terrera, Graciela
   Ritchie, Craig W.
TI 11?-hydroxysteroid dehydrogenase type 1 inhibitor use in human disease
   -a systematic review and narrative synthesis
SO METABOLISM-CLINICAL AND EXPERIMENTAL
LA English
DT Review
ID POSTTRAUMATIC-STRESS-DISORDER; SUBCUTANEOUS ADIPOSE-TISSUE; IMPROVES
   COGNITIVE FUNCTION; HUMAN FETAL MEMBRANES; HPA-AXIS; METABOLIC-SYNDROME;
   11-BETA-HYDROXYSTEROID DEHYDROGENASE-1; NEUROCOGNITIVE FUNCTION;
   MIFEPRISTONE RU-486; GLUCOSE-METABOLISM
C1 [Gregory, Sarah; Hill, David; Grey, Ben; Muniz-Terrera, Graciela; Ritchie, Craig W.] Univ Edinburgh, Ctr Dementia Prevent, Ctr Clin Brain Sci, Edinburgh, Midlothian, Scotland.
   [Ketelbey, William; Miller, Tamara] Actinogen Med Ltd, Sydney, NSW, Australia.
C3 University of Edinburgh
RP Gregory, S (corresponding author), Edinburgh Dementia Prevent, Biocube 1,9 Little France Rd, Edinburgh EH16 4UX, Midlothian, Scotland.
EM Sarah.Gregory@ed.ac.uk
RI Gregory, Sarah/AAL-4984-2020; Grey, Ben/AAX-6773-2020
OI Gregory, Sarah/0000-0001-9864-8240
FU Actinogen Medical Ltd.
FX This work was funded by Actinogen Medical Ltd.
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NR 109
TC 30
Z9 31
U1 0
U2 1
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0026-0495
EI 1532-8600
J9 METABOLISM
JI Metab.-Clin. Exp.
PD JUL
PY 2020
VL 108
AR 154246
DI 10.1016/j.metabol.2020.154246
PG 18
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism
GA MB4CH
UT WOS:000542550800008
PM 32333937
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Brody, GH
   Yu, TY
   Chen, E
   Miller, GE
AF Brody, Gene H.
   Yu, Tianyi
   Chen, Edith
   Miller, Gregory E.
TI Persistence of Skin-Deep Resilience in African American Adults
SO HEALTH PSYCHOLOGY
LA English
DT Article
DE African Americans; insulin resistance; metabolic syndrome; poverty;
   psychological resilience
ID SELF-CONTROL; ALLOSTATIC LOAD; MENTAL-HEALTH; EXPERIENCES; STRESS;
   ABUSE; RACE
AB Objective: The skin-deep resilience pattern suggests that, for low-socioeconomic-status African American youths, the ability to maintain high self-control and to persist with efforts to succeed may act as a double-edged sword, facilitating academic success and adjustment while undermining physical health. We extend research by following a sample of rural African Americans, asking whether the skin-deep resilience pattern, evident during adolescence, persists into adulthood by increasing susceptibility to metabolic syndrome (MetS) and insulin resistance (IR). Methods: The sample included 368 11-year-old African Americans, their parents, and their teachers. Parents provided data on family poverty across ages 11-18 years. Teachers provided data on youths' planful self-control across ages 11-13 years. At age 27 years, participants completed questionnaires about educational attainment and psychological adjustment and provided a fasting blood sample from which MetS and IR were assessed. Results: Regardless of years spent living in poverty, planful self-control during childhood was associated with college graduation (p<.001) and with low levels of depressive symptoms (p=.016) and antisocial behavior (p=.028). For participants exhibiting high levels of self-control, however, living more years in poverty across adolescence was associated with a greater number of MetS components that met clinical cutoff criteria (p=.018) and greater IR (p=.016) during adulthood. Conclusions: The skin-deep resilience pattern persists into adulthood, particularly among those who spent more of their adolescence living in poverty, and increases vulnerability to MetS and IR while it also promotes college graduation and positive psychological adjustment.
C1 [Brody, Gene H.; Yu, Tianyi] Univ Georgia, Ctr Family Res, 1095 Coll Stn Rd, Athens, GA 30602 USA.
   [Chen, Edith; Miller, Gregory E.] Northwestern Univ, Dept Psychol, Evanston, IL 60208 USA.
C3 University System of Georgia; University of Georgia; Northwestern
   University
RP Brody, GH (corresponding author), Univ Georgia, Ctr Family Res, 1095 Coll Stn Rd, Athens, GA 30602 USA.
EM gbrody@uga.edu
OI Miller, Gregory/0000-0002-7217-1082
FU National Institute of Child Health and Human Development [R01 HD030588];
   National Institute on Drug Abuse [P30 DA027827]
FX This research was supported by the National Institute of Child Health
   and Human Development (R01 HD030588) and the National Institute on Drug
   Abuse (P30 DA027827). The content is solely the responsibility of the
   authors and does not necessarily represent the official views of the
   Eunice Kennedy Shriver National Institute of Child Health and Human
   Development, the National Institute on Drug Abuse, or the National
   Institutes of Health.
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NR 33
TC 43
Z9 56
U1 2
U2 30
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 0278-6133
EI 1930-7810
J9 HEALTH PSYCHOL
JI Health Psychol.
PD OCT
PY 2020
VL 39
IS 10
BP 921
EP 926
DI 10.1037/hea0000945
PG 6
WC Psychology, Clinical; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology
GA OE4WK
UT WOS:000580532400008
PM 32597677
OA Green Accepted, hybrid
DA 2025-06-11
ER

PT J
AU Parati, G
   Omboni, S
   Compare, A
   Grossi, E
   Callus, E
   Venco, A
   Destro, M
   Villa, G
   Palatini, P
   Rosei, EA
   Scalvini, S
   Taddei, S
   Manfellotto, D
   Favale, S
   De Matteis, C
   Guglielmi, M
AF Parati, Gianfranco
   Omboni, Stefano
   Compare, Angelo
   Grossi, Enzo
   Callus, Edward
   Venco, Achille
   Destro, Maurizio
   Villa, Giuseppe
   Palatini, Paolo
   Rosei, Enrico Agabiti
   Scalvini, Simonetta
   Taddei, Stefano
   Manfellotto, Dario
   Favale, Stefano
   De Matteis, Carmine
   Guglielmi, Michele
CA TELEBPMET Study Grp
TI Blood pressure control and treatment adherence in hypertensive patients
   with metabolic syndrome: protocol of a randomized controlled study based
   on home blood pressure telemonitoring vs. conventional management and
   assessment of psychological determinants of adherence (TELEBPMET Study)
SO TRIALS
LA English
DT Article
DE Hypertension; Blood pressure; Home blood pressure telemonitoring;
   Adherence; Anxiety; Depression; Personality traits
ID CORONARY-HEART-DISEASE; CARDIOVASCULAR-DISEASE; EUROPEAN-SOCIETY;
   ANTIHYPERTENSIVE THERAPY; INTERNATIONAL PROTOCOL; PSYCHIATRIC-PATIENTS;
   SELF-MEASUREMENT; MORTALITY; VALIDATION; IMPACT
AB Background: Inadequate blood pressure control and poor adherence to treatment remain among the major limitations in the management of hypertensive patients, particularly of those at high risk of cardiovascular events. Preliminary evidence suggests that home blood pressure telemonitoring (HBPT) might help increasing the chance of achieving blood pressure targets and improve patient's therapeutic adherence. However, all these potential advantages of HBPT have not yet been fully investigated.
   Methods/design: The purpose of this open label, parallel group, randomized, controlled study is to assess whether, in patients with high cardiovascular risk (treated or untreated essential arterial hypertension - both in the office and in ambulatory conditions over 24 h - and metabolic syndrome), long-term (48 weeks) blood pressure control is more effective when based on HBPT and on the feedback to patients by their doctor between visits, or when based exclusively on blood pressure determination during quarterly office visits (conventional management (CM)). A total of 252 patients will be enrolled and randomized to usual care (n=84) or HBPT (n=168). The primary study endpoint will be the rate of subjects achieving normal daytime ambulatory blood pressure targets (<135/85 mmHg) 24 weeks and 48 weeks after randomization. In addition, the study will assess the psychological determinants of adherence and persistence to drug therapy, through specific psychological tests administered during the course of the study. Other secondary study endpoints will be related to the impact of HBPT on additional clinical and economic outcomes (number of additional medical visits, direct costs of patient management, number of antihypertensive drugs prescribed, level of cardiovascular risk, degree of target organ damage and rate of cardiovascular events, regression of the metabolic syndrome).
   Discussion: The TELEBPMET Study will show whether HBPT is effective in improving blood pressure control and related medical and economic outcomes in hypertensive patients with metabolic syndrome. It will also provide a comprehensive understanding of the psychological determinants of medication adherence and blood pressure control of these patients.
C1 [Parati, Gianfranco] Univ Milano Bicocca, Ist Auxol Italiano, IRCCS Osped San Luca, Dept Cardiol, Milan, Italy.
   [Parati, Gianfranco] Univ Milano Bicocca, Dept Clin Med & Prevent, Milan, Italy.
   [Omboni, Stefano] Italian Inst Telemed, Varese, Italy.
   [Compare, Angelo] Univ Bergamo, Dept Human Sci, Bergamo, Italy.
   [Grossi, Enzo] Ctr Diagnost Italiano, Milan, Italy.
   [Callus, Edward] IRCCS Policlin San Donato, Dept Pediat Cardiol, Milan, Italy.
   [Callus, Edward] IRCCS Policlin San Donato, Adult Congenital Heart Ctr, Milan, Italy.
   [Venco, Achille] Univ Insubria, Osped Circolo, Centro Ipertens, Varese, Italy.
   [Destro, Maurizio] Treviglio Caravaggio Hosp, Gen Med Unit, Med Dept AO, Treviglio, Italy.
   [Villa, Giuseppe] Ist Sci Pavia, IRCCS Fdn Salvatore Maugeri, Div Nefrol & Emodialisi, Pavia, Italy.
   [Palatini, Paolo] Univ Padua, Policlin Univ, Ist Clin Med 4, Padua, Italy.
   [Rosei, Enrico Agabiti] Univ Brescia, Clin Med, AO Spedali Civili Brescia, Brescia, Italy.
   [Scalvini, Simonetta] IRCCS Fdn Salvatore Maugeri, Serv Autonomo Telemed, Brescia, Italy.
   [Taddei, Stefano] Univ Pisa, Azienda Osped Univ Santa Chiara, Dipartimento Med Interna, Pisa, Italy.
   [Manfellotto, Dario] Osped S Giovanni Calibita Fatebenefratelli, Rome, Italy.
   [Favale, Stefano] Univ Bari, UO Cardiol, Azienda Osped Policlin, Bari, Italy.
   [De Matteis, Carmine] Presidio Osped San Felice Cancello, Ctr Prevenz Malattie Cardiovasc, UOSD Serv Prevenz & Riabilitaz Cardiopat, San Felice A Cancello, Caserta, Italy.
   [Guglielmi, Michele] Casa Cura Tortorella, Salerno, Italy.
C3 IRCCS Istituto Auxologico Italiano; University of Milano-Bicocca;
   University of Milano-Bicocca; University of Bergamo; IRCCS Policlinico
   San Donato; IRCCS Policlinico San Donato; Ospedale Circolo & Fondazione
   Macchi; University of Insubria; Ospedale di Treviglio-Caravaggio;
   Istituti Clinici Scientifici Maugeri IRCCS; University of Padua;
   Hospital Spedali Civili Brescia; University of Brescia; Istituti Clinici
   Scientifici Maugeri IRCCS; University of Pisa; Azienda Ospedaliero
   Universitaria Pisana; Universita degli Studi di Bari Aldo Moro
RP Parati, G (corresponding author), Univ Milano Bicocca, Ist Auxol Italiano, IRCCS Osped San Luca, Dept Cardiol, Milan, Italy.
EM gianfranco.parati@unimib.it
RI Taddei, Stefano/AAB-2828-2019; Callus, Edward/P-6410-2019; Grossi,
   Enzo/AAF-7765-2020; scalvini, simonetta/AAB-8992-2020; Compare, Prof.
   Angelo/H-3519-2014; Callus, Edward/G-3246-2018; Omboni,
   Stefano/D-1327-2015; Parati, Gianfranco/K-7151-2016
OI scalvini, simonetta/0000-0001-7387-505X; Compare, Prof.
   Angelo/0000-0002-3336-7920; Callus, Edward/0000-0001-9286-1825; Omboni,
   Stefano/0000-0002-7124-2096; GROSSI, ENZO/0000-0003-0346-2684; Forleo,
   Cinzia/0000-0002-9452-4037; Della Rosa, Francesco/0000-0002-6834-9124;
   Parati, Gianfranco/0000-0001-9402-7439; maresca, andrea
   maria/0000-0001-7896-2021
FU Bracco Pharmaceuticals
FX GP has received honoraria for lectures by Omron and Microlife companies,
   manufacturers of home blood pressure devices. SO is Scientific
   Consultant of Biotechmed Ltd., manufacturer of the Morepress
   telemedicine system used in this study. EG is Medical Director of Bracco
   Pharmaceuticals, the company sponsoring the project. All the other
   authors declare that they have no competing interests.
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NR 50
TC 33
Z9 35
U1 0
U2 26
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1745-6215
J9 TRIALS
JI Trials
PD JAN 23
PY 2013
VL 14
AR 22
DI 10.1186/1745-6215-14-22
PG 11
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Research & Experimental Medicine
GA 092KH
UT WOS:000315119100001
PM 23343138
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Chen, SF
   Henderson, A
   Petriello, MC
   Romano, KA
   Gearing, M
   Miao, J
   Schell, M
   Sandoval-Espinola, WJ
   Tao, JH
   Sha, BD
   Graham, M
   Crooke, R
   Kleinridders, A
   Balskus, EP
   Rey, FE
   Morris, AJ
   Biddinger, SB
AF Chen, Sifan
   Henderson, Ayana
   Petriello, Michael C.
   Romano, Kymberleigh A.
   Gearing, Mary
   Miao, Ji
   Schell, Mareike
   Sandoval-Espinola, Walter J.
   Tao, Jiahui
   Sha, Bingdong
   Graham, Mark
   Crooke, Rosanne
   Kleinridders, Andre
   Balskus, Emily P.
   Rey, Federico E.
   Morris, Andrew J.
   Biddinger, Sudha B.
TI Trimethylamine N-Oxide Binds and Activates PERK to Promote Metabolic
   Dysfunction
SO CELL METABOLISM
LA English
DT Article
ID ENDOPLASMIC-RETICULUM STRESS; INSULIN-RESISTANCE; ER STRESS;
   SMALL-MOLECULE; EXPRESSION; GLUCOSE; CELLS; LIVER; MICE; TMAO
AB The gut-microbe-derived metabolite trimethylamine N-oxide (TMAO) is increased by insulin resistance and associated with several sequelae of metabolic syndrome in humans, including cardiovascular, renal, and neurodegenerative disease. The mechanism by which TMAO promotes disease is unclear. We now reveal the endoplasmic reticulum stress kinase PERK (EIF2AK3) as a receptor for TMAO: TMAO binds to PERK at physiologically relevant concentrations; selectively activates the PERK branch of the unfolded protein response; and induces the transcription factor FoxO1, a key driver of metabolic disease, in a PERK-dependent manner. Furthermore, interventions to reduce TMAO, either by manipulation of the gut microbiota or by inhibition of the TMAO synthesizing enzyme, flavin-containing monooxygenase 3, can reduce PERK activation and FoxO1 levels in the liver. Taken together, these data suggest TMAO and PERK may be central to the pathogenesis of the metabolic syndrome.
C1 [Chen, Sifan] Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Med Res Ctr, Guangzhou, Guangdong, Peoples R China.
   [Chen, Sifan; Henderson, Ayana; Gearing, Mary; Miao, Ji; Biddinger, Sudha B.] Harvard Med Sch, Boston Childrens Hosp, Div Endocrinol, Boston, MA 02115 USA.
   [Petriello, Michael C.; Morris, Andrew J.] Univ Kentucky, Coll Med, Div Cardiovasc Med, Lexington, KY USA.
   [Petriello, Michael C.; Morris, Andrew J.] Lexington Vet Affairs Med Ctr, Lexington, KY USA.
   [Romano, Kymberleigh A.; Rey, Federico E.] Univ Wisconsin, Dept Bacteriol, Madison, WI 53706 USA.
   [Schell, Mareike; Kleinridders, Andre] German Inst Human Nutr, Cent Regulat Metab, D-14558 Nuthetal, Germany.
   [Schell, Mareike; Kleinridders, Andre] German Ctr Diabet Res, D-85764 Munich, Germany.
   [Sandoval-Espinola, Walter J.; Balskus, Emily P.] Harvard Univ, Dept Chem & Chem Biol, Cambridge, MA 02138 USA.
   [Tao, Jiahui; Sha, Bingdong] Univ Alabama Birmingham, Dept Cell Dev & Integrat Biol, Birmingham, AL USA.
   [Graham, Mark; Crooke, Rosanne] Ionis Pharmaceut, Carlsbad, CA USA.
C3 Sun Yat Sen University; Harvard University; Harvard University Medical
   Affiliates; Boston Children's Hospital; Harvard Medical School;
   University of Kentucky; US Department of Veterans Affairs; Veterans
   Health Administration (VHA); Lexington VA Medical Center; University of
   Wisconsin System; University of Wisconsin Madison; Leibniz Association;
   Deutsches Institut fur Ernahrungsforschung Potsdam-Rehbrucke (DIfE);
   German Center for Diabetes Research (DZD); Harvard University;
   University of Alabama System; University of Alabama Birmingham; Ionis
   Pharmaceuticals, Inc.
RP Biddinger, SB (corresponding author), Harvard Med Sch, Boston Childrens Hosp, Div Endocrinol, Boston, MA 02115 USA.
EM sudha.biddinger@childrens.harvard.edu
RI Sandoval-Espinola, Walter/X-7493-2019; Miao, Ji/F-9398-2015
OI Schell, Mareike/0000-0002-9999-445X; Kleinridders,
   Andre/0000-0002-4248-6366; Henderson, Ayana/0000-0001-8591-284X; Miao,
   Ji/0000-0003-0869-4492
FU American Heart Association; German Ministry of Education and Research
   (BMBF); State of Brandenburg (DZD) [82DZD00302];  [R01HL109650]; 
   [R00DK100539]
FX These studies were supported by R01HL109650 (S.B.B.), the American Heart
   Association (Established Investigator Award to S.B.B.), and R00DK100539
   (J.M.). M.S. and A.K. were supported by a grant from the German Ministry
   of Education and Research (BMBF) and the State of Brandenburg (DZD grant
   82DZD00302).
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NR 83
TC 267
Z9 290
U1 6
U2 94
PU CELL PRESS
PI CAMBRIDGE
PA 50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA
SN 1550-4131
EI 1932-7420
J9 CELL METAB
JI Cell Metab.
PD DEC 3
PY 2019
VL 30
IS 6
BP 1141
EP +
DI 10.1016/j.cmet.2019.08.021
PG 16
WC Cell Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Endocrinology & Metabolism
GA JT2BD
UT WOS:000500800300014
PM 31543404
OA Bronze
DA 2025-06-11
ER

PT S
AU Itoh, H
   Kanayama, N
AF Itoh, Hiroaki
   Kanayama, Naohiro
BE Kubota, T
   Fukuoka, H
TI Developmental Origins of Nonalcoholic Fatty Liver Disease (NAFLD)
SO DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE (DOHAD): FROM BIOLOGICAL
   BASIS TO CLINICAL SIGNIFICANCE
SE Advances in Experimental Medicine and Biology
LA English
DT Article; Book Chapter
DE Metabolic syndrome; Birth weight; Obesity; Nutrition; Pregnancy;
   Developmental origins of health and disease (DOHaD); Fatty liver
ID INTRAUTERINE GROWTH-RETARDATION; ENDOPLASMIC-RETICULUM STRESS;
   LOW-BIRTH-WEIGHT; BODY-MASS INDEX; MATERNAL OBESITY; RISK-FACTORS;
   INSULIN-RESISTANCE; HEPATIC STEATOSIS; ADULT MICE; METABOLIC SYNDROME
AB Nonalcoholic fatty liver disease (NAFLD) is a hepatic manifestation of metabolic syndrome. Its prevalence is currently increasing not only in developed obese countries but also in developing countries. Recent findings from human cohorts and animal studies suggest that a nutritional imbalance in the early critical period is causatively associated with the incidence of NAFLD in later life. Based on the current theory of the developmental origins of health and disease (DOHaD), undernourishment and overnourishment in utero are both hypothesized to prime the predisposition for hepatic fat storage. Current knowledge on the developmental origins of NAFLD is introduced in this chapter.
C1 [Itoh, Hiroaki; Kanayama, Naohiro] Hamamatsu Univ Sch Med, Dept Obstet & Gynecol, Higashi Ku, Hamamatsu, Shizuoka, Japan.
C3 Hamamatsu University School of Medicine
RP Itoh, H (corresponding author), Hamamatsu Univ Sch Med, Dept Obstet & Gynecol, Higashi Ku, Hamamatsu, Shizuoka, Japan.
EM hitou-endo@umin.ac.jp
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NR 83
TC 12
Z9 14
U1 0
U2 9
PU SPRINGER-VERLAG SINGAPORE PTE LTD
PI SINGAPORE
PA 152 BEACH ROAD, #21-01/04 GATEWAY EAST, SINGAPORE, 189721, SINGAPORE
SN 0065-2598
EI 2214-8019
BN 978-981-10-5526-3; 978-981-10-5525-6
J9 ADV EXP MED BIOL
JI Adv.Exp.Med.Biol.
PY 2018
VL 1012
BP 29
EP 39
DI 10.1007/978-981-10-5526-3_4
D2 10.1007/978-981-10-5526-3
PG 11
WC Developmental Biology; Medicine, Research & Experimental
WE Book Citation Index – Science (BKCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Developmental Biology; Research & Experimental Medicine
GA BL6IW
UT WOS:000454295200005
PM 29956192
DA 2025-06-11
ER

PT J
AU Tian, YE
   Di Biase, MA
   Mosley, PE
   Lupton, MK
   Xia, Y
   Fripp, J
   Breakspear, M
   Cropley, V
   Zalesky, A
AF Tian, Ye Ella
   Di Biase, Maria A.
   Mosley, Philip E.
   Lupton, Michelle K.
   Xia, Ying
   Fripp, Jurgen
   Breakspear, Michael
   Cropley, Vanessa
   Zalesky, Andrew
TI Evaluation of Brain-Body Health in Individuals With Common
   Neuropsychiatric Disorders
SO JAMA PSYCHIATRY
LA English
DT Article
ID MAJOR DEPRESSIVE DISORDER; SERIOUS MENTAL-ILLNESS; PHYSICAL HEALTH;
   ALZHEIMERS-DISEASE; METABOLIC SYNDROME; BIPOLAR DISORDER; MOOD
   DISORDERS; PRIMARY-CARE; MATTER LOSS; PEOPLE
AB IMPORTANCE Physical health and chronic medical comorbidities are underestimated, inadequately treated, and often overlooked in psychiatry. A multiorgan, systemwide characterization of brain and body health in neuropsychiatric disorders may enable systematic evaluation of brain-body health status in patients and potentially identify new therapeutic targets.
   OBJECTIVE To evaluate the health status of the brain and 7 body systems across common neuropsychiatric disorders.
   DESIGN, SETTING, AND PARTICIPANTS Brain imaging phenotypes, physiological measures, and blood- and urine-based markers were harmonized across multiple population-based neuroimaging biobanks in the US, UK, and Australia, including UK Biobank; Australian Schizophrenia Research Bank; Australian Imaging, Biomarkers, and Lifestyle Flagship Study of Ageing; Alzheimer's Disease Neuroimaging Initiative; Prospective Imaging Study of Ageing; Human Connectome Project-Young Adult; and Human Connectome Project-Aging. Cross-sectional data acquired between March 2006 and December 2020 were used to study organ health. Data were analyzed from October 18, 2021, to July 21, 2022. Adults aged 18 to 95 years with a lifetime diagnosis of 1 or more common neuropsychiatric disorders, including schizophrenia, bipolar disorder, depression, generalized anxiety disorder, and a healthy comparison group were included.
   MAIN OUTCOMES AND MEASURES Deviations from normative reference ranges for composite health scores indexing the health and function of the brain and 7 body systems. Secondary outcomes included accuracy of classifying diagnoses (disease vs control) and differentiating between diagnoses (disease vs disease), measured using the area under the receiver operating characteristic curve (AUC).
   RESULTS Therewere 85 748 participants with preselected neuropsychiatric disorders (36 324 male) and 87 420 healthy control individuals (40560 male) included in this study. Body health, especially scores indexingmetabolic, hepatic, and immune health, deviated from normative reference ranges for all 4 neuropsychiatric disorders studied. Poor body healthwas a more pronounced illness manifestation compared to brain changes in schizophrenia (AUC for body = 0.81 [95% CI, 0.79-0.82]; AUC for brain = 0.79 [95% CI, 0.79-0.79]), bipolar disorder (AUC for body = 0.67 [95% CI, 0.67-0.68]; AUC for brain = 0.58 [95% CI, 0.57-0.58]), depression (AUC for body = 0.67 [95% CI, 0.67-0.68]; AUC for brain = 0.58 [95% CI, 0.58-0.58]), and anxiety (AUC for body = 0.63 [95% CI, 0.63-0.63]; AUC for brain = 0.57 [95% CI, 0.57-0.58]). However, brain health enabled more accurate differentiation between distinct neuropsychiatric diagnoses than body health (schizophrenia-other: mean AUC for body = 0.70 [95% CI, 0.70-0.71] and mean AUC for brain = 0.79 [95% CI, 0.79-0.80]; bipolar disorder-other: mean AUC for body = 0.60 [95% CI, 0.59-0.60] and mean AUC for brain = 0.65 [95% CI, 0.65-0.65]; depression-other: mean AUC for body = 0.61 [95% CI, 0.60-0.63] and mean AUC for brain = 0.65 [95% CI, 0.65-0.66]; anxiety-other: mean AUC for body = 0.63 [95% CI, 0.62-0.63] and mean AUC for brain = 0.66 [95% CI, 0.65-0.66).
   CONCLUSIONS AND RELEVANCE In this cross-sectional study, neuropsychiatric disorders shared a substantial and largely overlapping imprint of poor body health. Routinely monitoring body health and integrated physical and mental health care may help reduce the adverse effect of physical comorbidity in people with mental illness.
C1 [Tian, Ye Ella; Di Biase, Maria A.; Cropley, Vanessa; Zalesky, Andrew] Univ Melbourne, Melbourne Neuropsychiat Ctr, Melbourne Med Sch, Dept Psychiat, Melbourne, Vic, Australia.
   [Mosley, Philip E.] Queensland Inst Med Res Berghofer Med Inst, Clin Brain Networks Grp, Brisbane, Qld, Australia.
   [Mosley, Philip E.] Queensland Brain Inst, Brisbane, Qld, Australia.
   [Mosley, Philip E.; Xia, Ying; Fripp, Jurgen] Australian E Hlth Res Ctr, Commonwealth Sci & Ind Res Org Hlth & Biosecur, Brisbane, Qld, Australia.
   [Lupton, Michelle K.] Queensland Inst Med Res, Berghofer Med Res Inst, Brisbane, Qld, Australia.
   [Breakspear, Michael] Univ Newcastle, Coll Hlth Med & Wellbeing, Discipline Psychiat, Newcastle, NSW, Australia.
   [Breakspear, Michael] Univ Newcastle, Coll Engn Sci & Environm, Sch Psychol Sci, Newcastle, NSW, Australia.
   [Zalesky, Andrew] Univ Melbourne, Fac Engn & Informat Technol, Dept Biomed Engn, Melbourne, Vic, Australia.
   [Tian, Ye Ella] Univ Melbourne, Melbourne Neuropsychiat Ctr, Melbourne Med Sch, Dept Psychiat, Level 3,Alan Gilbert Bldg,161 Barry St, Melbourne, Vic 3053, Australia.
C3 University of Melbourne; University of Queensland; Commonwealth
   Scientific & Industrial Research Organisation (CSIRO); QIMR Berghofer
   Medical Research Institute; University of Newcastle; University of
   Newcastle; University of Melbourne; University of Melbourne
RP Tian, YE (corresponding author), Univ Melbourne, Melbourne Neuropsychiat Ctr, Melbourne Med Sch, Dept Psychiat, Level 3,Alan Gilbert Bldg,161 Barry St, Melbourne, Vic 3053, Australia.
EM ye.tian2@unimelb.edu.au
RI Tian, Ye/IAM-2801-2023; Zalesky, Andrew/ABZ-1225-2022; Di Biase,
   Maria/AAJ-3118-2021; Mosley, Philip/AAB-7205-2019; Breakspear,
   Michael/ABF-6302-2020; Xia, Ying/O-9932-2018; Fripp, Jurgen/A-8763-2011
OI Di Biase, Maria/0000-0002-7100-651X; Tian, Ye/0000-0003-3107-5550; Xia,
   Ying/0000-0003-3107-7759; Fripp, Jurgen/0000-0001-9705-0079
FU Mary Lugton Postdoctoral Fellowship; Senior Rebecca L. Cooper
   Fellowship; National Health and Medical Research Council [APP1177370,
   APP2008612]; Alzheimer's Disease Neuroimaging Initiative (ADNI)
   (National Institutes of Health) [U01 AG024904]; Department of Defense
   ADNI [W81XWH-12-2-0012]
FX Dr Tian was supported by the Mary Lugton Postdoctoral Fellowship. Dr
   Zalesky was supported by the Senior Rebecca L. Cooper Fellowship. Dr
   Cropley was supported by National Health and Medical Research Council
   grant APP1177370. Dr Breakspear was supported by National Health and
   Medical Research Council grant APP2008612. Some of the data collection
   andsharing for this project was funded by the Alzheimer's Disease
   Neuroimaging Initiative (ADNI) (National Institutes of Health Grant U01
   AG024904) and Department of Defense ADNI (Department of Defense award
   number W81XWH-12-2-0012).
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NR 71
TC 38
Z9 39
U1 12
U2 30
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 2168-622X
EI 2168-6238
J9 JAMA PSYCHIAT
JI JAMA Psychiatry
PD JUN
PY 2023
VL 80
IS 6
BP 567
EP 576
DI 10.1001/jamapsychiatry.2023.0791
EA APR 2023
PG 10
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA I6AT6
UT WOS:000980130900002
PM 37099313
OA Green Published
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Mohammadi, S
   Ziaei, S
   Morvaridi, M
   Hasani, M
   Mirtaheri, E
   Farsi, F
   Ebrahimi, S
   Daneshzad, E
   Heshmati, J
AF Mohammadi, Shooka
   Ziaei, Somayeh
   Morvaridi, Mehrnaz
   Hasani, Motahareh
   Mirtaheri, Elham
   Farsi, Farnaz
   Ebrahimi, Sara
   Daneshzad, Elnaz
   Heshmati, Javad
TI Impacts of Curcumin Supplementation on Cardiometabolic Risk Factors in
   Patients With Polycystic Ovary Syndrome: A Systematic Review and
   Dose-Response Meta-Analysis
SO HEALTH SCIENCE REPORTS
LA English
DT Review
DE cardiometabolic; cardiovascular; curcumin; polycystic ovary syndrome
ID OXIDATIVE STRESS; BLOOD-GLUCOSE; WOMEN; HYPERANDROGENISM; PREVALENCE;
   DIAGNOSIS; DISEASES; HEALTH; BIAS; AMPK
AB Background and AimPatients with polycystic ovary syndrome (PCOS) commonly have cardiometabolic risk factors. Oxidative stress (OS) significantly contributes to the development of cardiometabolic diseases. Curcumin (CUR) exhibits antioxidant properties that aid in OS regulation. This systematic review and dose-response meta-analysis of randomized clinical trials (RCTs) evaluated the effects of CUR supplementation on cardiometabolic risk factors in women with PCOS. MethodsA systematic search across various databases was implemented to identify eligible RCTs published until January 2024. A meta-analysis was conducted employing a random-effects model. ResultsEight RCTs were included in the meta-analysis. It was indicated that CUR supplementation substantially reduced fasting blood sugar (FBS) (standardized mean difference [SMD]: -0.40 mg/dL, 95% confidence interval [CI]: -0.59, -0.21; p < 0.001), insulin (SMD: -0.32 <mu>U/mL, 95% CI: -0.49, -0.14; p < 0.001), homeostasis model assessment of insulin resistance (HOMA-IR) (SMD: -0.36, 95% CI: -0.54, -0.19; p < 0.001), and total cholesterol (TC) (SMD: -0.34 mg/dL, 95% CI: -0.61, -0.08; p = 0.01). In addition, it substantially increased the quantitative insulin sensitivity check index (QUICKI) (SMD: 0.37, 95% CI: 0.13, 0.61; p < 0.001) in the CUR-treated group compared with the control group. However, CUR did not have significant impacts on body mass index (BMI), body weight, serum levels of follicle-stimulating hormone (FSH), triglycerides (TG), dehydroepiandrosterone (DHEA), high-density lipoprotein (HDL), testosterone, low-density lipoprotein (LDL), and luteinizing hormone (LH). ConclusionThis study revealed that CUR may have the potential to enhance cardiometabolic health by reducing hyperglycemia, insulin resistance, and serum TC levels in women with PCOS.
C1 [Mohammadi, Shooka] Ahvaz Jundishapur Univ Med Sci, Nutr & Metab Dis Res Ctr, Ahvaz, Iran.
   [Mohammadi, Shooka] Univ Malaya, Fac Med, Dept Social & Prevent Med, Kuala Lumpur, Malaysia.
   [Ziaei, Somayeh] Kermanshah Univ Med Sci, Imam Reza Hosp, Departemt Anesthesia, Kermanshah, Iran.
   [Morvaridi, Mehrnaz] Iran Univ Med Sci, Sch Publ Hlth, Tehran, Iran.
   [Hasani, Motahareh] Golestan Univ Med Sci, Sch Hlth, Dept Nutr Sci, Gorgan, Golestan, Iran.
   [Mirtaheri, Elham] Ohio State Univ, Dept Human Sci, Human Nutr Program, Columbus, OH USA.
   [Farsi, Farnaz] Iran Univ Med Sci, Minimally Invas Surg Res Ctr, Tehran, Iran.
   [Ebrahimi, Sara] Deakin Univ, Inst Phys Act & Nutr, Sch Exercise & Nutr Sci, Geelong, Vic, Australia.
   [Daneshzad, Elnaz] Alborz Univ Med Sci, Noncommunicable Dis Res Ctr, Karaj, Iran.
   [Heshmati, Javad] Univ Ottawa Heart Inst, Ottawa, ON, Canada.
C3 Ahvaz Jundishapur University of Medical Sciences (AJUMS); Universiti
   Malaya; Kermanshah University of Medical Sciences; Iran University of
   Medical Sciences; Golestan University of Medical Sciences; University
   System of Ohio; Ohio State University; Iran University of Medical
   Sciences; Deakin University; Alborz University of Medical Sciences;
   University of Ottawa; University of Ottawa Heart Institute
RP Mohammadi, S (corresponding author), Ahvaz Jundishapur Univ Med Sci, Nutr & Metab Dis Res Ctr, Ahvaz, Iran.; Mohammadi, S (corresponding author), Univ Malaya, Fac Med, Dept Social & Prevent Med, Kuala Lumpur, Malaysia.; Heshmati, J (corresponding author), Univ Ottawa Heart Inst, Ottawa, ON, Canada.
EM shooka.mohammadi@gmail.com; Javad.heshmati@gmail.com
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NR 137
TC 0
Z9 0
U1 1
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
EI 2398-8835
J9 HEALTH SCI REP-US
JI Health Sci. Rep.
PD MAR
PY 2025
VL 8
IS 3
AR e70525
DI 10.1002/hsr2.70525
PG 17
WC Public, Environmental & Occupational Health; Medicine, General &
   Internal
WE Emerging Sources Citation Index (ESCI)
SC Public, Environmental & Occupational Health; General & Internal Medicine
GA 1NV6N
UT WOS:001469451300001
PM 40041784
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Pérez-Manchón, D
   Barrio-Cortes, J
   Vicario-Merino, A
   Mayoral-Gonzalo, N
   Ruiz-López, M
   Corral-Pugnaire, E
   Blanco-Hermo, P
   Ruiz-Zaldibar, C
AF Perez-Manchon, David
   Barrio-Cortes, Jaime
   Vicario-Merino, Angel
   Mayoral-Gonzalo, Noemi
   Ruiz-Lopez, Montserrat
   Corral-Pugnaire, Eduardo
   Blanco-Hermo, Patricia
   Ruiz-Zaldibar, Cayetana
TI Cardiometabolic Risk in a University Community: An Observational Study
SO HEALTHCARE
LA English
DT Article
DE cardiometabolic risk; university personnel; health promotion; nursing
ID PHYSICAL-ACTIVITY; CARDIOVASCULAR-DISEASE; HEALTH-PROMOTION; EMPLOYEES;
   OVERWEIGHT; PROGRAMS; OBESITY; WORK
AB The highest prevalence of cardiovascular risk factors has been associated with obesity, sedentary lifestyle, and elevated blood pressure due to high workload and work stress. This study aimed to analyze the cardiometabolic risk and lifestyles among the health sciences university academics and campus administrators at a private university in Spain. A cross-sectional study was conducted during the 2018-2019 academic year by the Nursing Department, using a self-administered questionnaire and face-to-face assessments of anthropometric variables related to cardiovascular risk in university personnel. The variables measured included sociodemographics, cardiovascular risk history, comorbidities, toxic habits, Mediterranean diet adherence, physical exercise, psychosocial stress, and physical, anthropometric, and analytical data. Cardiovascular risk was categorized into relative (<40 years), absolute, and vascular age (>40 years). Among the 101 participants, 61.4% were women, with a mean age of 41.3 years +/- 9 years. The smoking prevalence was 21.8% (68.2% women), 27.7% were sedentary, and 51.0% adhered to the Mediterranean diet, with higher adherence among the academics. Emotional risk was present in 32.7% of the participants. A prior diagnosis of hypertension was significantly more frequent in the men (15.4%) compared to the women (3.2%). The blood pressure measurements were mostly optimal across both genders and professional groups, but the proportion of hypertension grade 1 was significantly higher among the academics (10%) compared to the administrators (4.5%) and among the men (11.1%) compared to the women (5.9%). The absolute cardiovascular risk among the university employees was generally low, but the men exhibited a more moderate risk compared to the women. It is necessary for the university to promote health within its community, with the Nursing Department playing a key role in health promotion and research.
C1 [Perez-Manchon, David; Barrio-Cortes, Jaime; Vicario-Merino, Angel; Mayoral-Gonzalo, Noemi; Ruiz-Lopez, Montserrat; Corral-Pugnaire, Eduardo; Blanco-Hermo, Patricia; Ruiz-Zaldibar, Cayetana] Univ Camilo Jose Cela, Fac HM Hlth Sci, Dept Nursing, Madrid 28692, Spain.
   [Perez-Manchon, David; Barrio-Cortes, Jaime; Vicario-Merino, Angel; Mayoral-Gonzalo, Noemi; Ruiz-Lopez, Montserrat; Corral-Pugnaire, Eduardo; Blanco-Hermo, Patricia; Ruiz-Zaldibar, Cayetana] HM Hosp, Hlth Res Inst, Madrid 28015, Spain.
C3 Camilo Jose Cela University
RP Barrio-Cortes, J (corresponding author), Univ Camilo Jose Cela, Fac HM Hlth Sci, Dept Nursing, Madrid 28692, Spain.; Barrio-Cortes, J (corresponding author), HM Hosp, Hlth Res Inst, Madrid 28015, Spain.
EM dpmanchon@ucjc.edu; jbarrio@ucjc.edu; avicario@ucjc.edu;
   nmayoral@ucjc.edu; mrlopez@ucjc.edu; ejcorral@ucjc.edu;
   pblanco@ucjc.edu; crzaldibar@ucjc.edu
RI Mayoral Gonzalo, Noemi/GSD-7477-2022; Barrio-Cortes,
   Jaime/AEL-9845-2022; Vicario-Merino, Angel/AAB-1666-2021; Perez-Manchon,
   David/HKP-1939-2023
OI Mayoral Gonzalo, Noemi/0000-0001-8902-8939; Barrio Cortes,
   Jaime/0000-0002-2582-0203; Vicario-Merino, Angel/0000-0002-4319-850X
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PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2227-9032
J9 HEALTHCARE-BASEL
JI Healthcare
PD SEP
PY 2024
VL 12
IS 17
AR 1756
DI 10.3390/healthcare12171756
PG 11
WC Health Care Sciences & Services; Health Policy & Services
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services
GA F9I3P
UT WOS:001312864800001
PM 39273780
OA gold
DA 2025-06-11
ER

PT J
AU Okop, KJ
   Levitt, N
   Puoane, T
AF Okop, Kufre Joseph
   Levitt, Naomi
   Puoane, Thandi
TI Factors Associated with Excessive Body Fat in Men and Women:
   Cross-Sectional Data from Black South Africans Living in a Rural
   Community and an Urban Township
SO PLOS ONE
LA English
DT Article
ID NUTRITION TRANSITION; WAIST CIRCUMFERENCE; METABOLIC SYNDROME; MASS
   INDEX; CARDIOMETABOLIC RISK; NORMAL-WEIGHT; OBESITY; PERCENTAGE; HEALTH;
   DETERMINANTS
AB Objective
   To determine the factors associated with excessive body fat among black African men and women living in rural and urban communities of South Africa.
   Methods
   This is a cross-sectional analysis of data from the Prospective Urban and Rural Epidemiology (PURE) study, Cape Town, South Africa conducted in 2009/2010. The study sample included 1220 participants (77.2% women) aged 35-70 years, for whom anthropometric measurements were obtained and risk factors documented through face-to-face interviews using validated international PURE study protocols. Sex-specific logistic regression models were used to evaluate socio-demographic, lifestyle and psychological factors associated with three excessive body fat indicators, namely body mass index (BMI), waist circumference (WC) and body fat percent (BF%).
   Results
   The prevalence of excessive body fat based on BF%, WC and BMI cut-offs were 96.0%, 86.1%, and 81.6% for women respectively, and 62.2%, 25.9%, and 36.0% for men respectively. The significant odds of excessive body fat among the currently married compared to unmarried were 4.1 (95% CI: 1.3-12.5) for BF% and 1.9 (95% CI: 1.3-2.9) for BMI among women; and 4.9 (95% CI: 2.6-9.6), 3.2 (95% CI: 1.6-6.4) and 3.6 (95% CI: 1.9-6.8) for BF%, WC and BMI respectively among men. Age <= 50 years (compared to age >50 years) was inversely associated with excessive BF% in men and women, and less-than-a-college education was inversely associated with excessive BMI and WC in men. Tobacco smoking was inversely associated with all three excessive adiposity indicators in women but not in men. Unemployment, depression, and stress did not predict excessive body fat in men or women.
   Conclusion
   The sex-differences in the socio-demographic and lifestyle factors associated with the high levels of excessive body fat in urban and rural women and men should be considered in packaging interventions to reduce obesity in these communities.
C1 [Okop, Kufre Joseph; Puoane, Thandi] Univ Western Cape, Sch Publ Hlth, ZA-7535 Bellville, South Africa.
   [Okop, Kufre Joseph; Levitt, Naomi; Puoane, Thandi] Univ Cape Town, Dept Med, Chron Dis Initiat Africa, ZA-7925 Cape Town, South Africa.
   [Levitt, Naomi] Univ Cape Town, Dept Med, Div Endocrinol & Diabet, ZA-7925 Cape Town, South Africa.
C3 University of the Western Cape; University of Cape Town; University of
   Cape Town
RP Okop, KJ (corresponding author), Univ Western Cape, Sch Publ Hlth, ZA-7535 Bellville, South Africa.
EM kufreokop@gmail.com
RI Okop, Kufre/J-1752-2019
OI Levitt, Naomi/0000-0001-6480-8066; Okop, Kufre/0000-0002-0841-4588
FU South African Medical Research Council; Population Health Research
   Institute of McMaster University, Canada; National Research Foundation
   of South Africa
FX This work was supported by the South African Medical Research Council
   (http://www.mrc.ac.za/), to TP; the Population Health Research Institute
   of McMaster University, Canada (http://www.phri.ca/), to TP; and the
   National Research Foundation of South Africa (http://www.nrf.ac.za/), to
   TP. The funders had no role in study design, data collection and
   analysis, decision to publish, or preparation of the manuscript.
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NR 45
TC 23
Z9 27
U1 0
U2 13
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD OCT 8
PY 2015
VL 10
IS 10
AR e0140153
DI 10.1371/journal.pone.0140153
PG 17
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA CT0TW
UT WOS:000362511000097
PM 26447880
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Chen, Y
   Dangardt, F
   Gelander, L
   Friberg, P
AF Chen, Yun
   Dangardt, Frida
   Gelander, Lars
   Friberg, Peter
TI Childhood BMI trajectories predict cardiometabolic risk and perceived
   stress at age 13 years: the STARS cohort
SO OBESITY
LA English
DT Article
ID BLOOD-PRESSURE; CHILDREN; OBESITY; ADIPOSITY; ADOLESCENCE; ADULTHOOD;
   MORTALITY; GROWTH; HEALTH; MASS
AB Objective: The aim of this study was to examine BMI trajectories from birth throughout childhood, associations with health outcomes at age 13 years, and time frames during which early-life BMI influenced adolescent health.Methods: Participants (1902, 44% male) reported perceived stress and psychosomatic symptoms and were examined for waist circumference (WC), systolic blood pressure (SBP), pulse wave velocity, and white blood cell counts (WBC). BMI trajectory was analyzed using group-based trajectory modeling of retrospective data of weight/height from birth throughout childhood. The authors performed linear regression to assess associations between BMI trajectories and health outcomes at age 13 years, presented as estimated mean differences with 95% CI among trajectories.Results: Three BMI trajectories were identified: normal; moderate; and excessive gain. Adjusting for covariates, adolescents with excessive gain had higher WC (19.2 [95% CI: 18.4-20.0] cm), SBP (3.6 [95% CI: 2.4-4.4] mm Hg), WBC (0.7 [95% CI: 0.4-0.9] x 109/L), and stress (1.1 [95% CI: 0.2-1.9]) than adolescents with normal gain. Higher WC (6.4 [95% CI: 5.8-6.9] cm), SBP (1.8 [95% CI: 1.0-2.5] mm Hg), and stress (0.7 [95% CI: 0.1-1.2]) were found in adolescents with moderate versus normal gain. The association of early-life BMI with SBP started around age 6 years with the excessive gain group, which was earlier than in the normal and moderate gain groups, in which it started at age 12 years.Conclusions: An excessive gain BMI trajectory from birth predicts cardiometabolic risk and stress in 13-year-old individuals.
C1 [Chen, Yun; Friberg, Peter] Univ Gothenburg, Inst Med, Sahlgrenska Acad, Sch Publ Hlth & Community Med, Gothenburg, Sweden.
   [Dangardt, Frida] Sahlgrens Univ Hosp, Queen Silvia Childrens Hosp, Childrens Heart Ctr, Gothenburg, Sweden.
   [Dangardt, Frida] Univ Gothenburg, Inst Med, Sahlgrenska Acad, Dept Mol & Clin Med, Gothenburg, Sweden.
   [Gelander, Lars] Univ Gothenburg, Sahlgrenska Acad, Inst Neurosci & Physiol, Dept Physiol Endocrinol, Gothenburg, Sweden.
   [Chen, Yun] Univ Gothenburg, Inst Med, Sch Publ Hlth & Community Med, Box 453, SE-40530 Gothenburg, Sweden.
C3 University of Gothenburg; Queen Silvia Children's Hospital; Sahlgrenska
   University Hospital; University of Gothenburg; University of Gothenburg;
   University of Gothenburg
RP Chen, Y (corresponding author), Univ Gothenburg, Inst Med, Sch Publ Hlth & Community Med, Box 453, SE-40530 Gothenburg, Sweden.
EM yun.chen@gu.se
RI Dangardt, Frida/AHC-9294-2022
OI Chen, Yun/0000-0002-3746-594X; Dangardt, Frida/0000-0003-4632-3916
FU Swedish Research Council
FX The authors thank the schools, adolescents, and parents who participated
   in this study, as well as Gun Bodehed Berg, Eva Gronowitz, Ann-Katrine
   Karlsson, Gustav Andersson, and Sandra Isaksson from Sahlgrenska
   University Hospital for their excellent efforts in recruiting and
   examining adolescents.
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NR 36
TC 1
Z9 1
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1930-7381
EI 1930-739X
J9 OBESITY
JI Obesity
PD MAR
PY 2024
VL 32
IS 3
BP 583
EP 592
DI 10.1002/oby.23966
EA DEC 2023
PG 10
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA KA8S8
UT WOS:001127800600001
PM 38112244
OA hybrid
DA 2025-06-11
ER

PT J
AU Panchal, SK
   Brown, L
AF Panchal, Sunil K.
   Brown, Lindsay
TI Rodent Models for Metabolic Syndrome Research
SO JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY
LA English
DT Review
ID HIGH-FAT-DIET; GOTO-KAKIZAKI RATS; SPONTANEOUSLY HYPERTENSIVE-RATS;
   MUSCLE INSULIN-RESISTANCE; INDUCED DIABETIC-RATS; FRUCTOSE CORN SYRUP;
   INDUCED OBESE MICE; BLOOD-PRESSURE; HEPATIC STEATOSIS; OXIDATIVE STRESS
AB Rodents are widely used to mimic human diseases to improve understanding of the causes and progression of disease symptoms and to test potential therapeutic interventions. Chronic diseases such as obesity, diabetes and hypertension, together known as the metabolic syndrome, are causing increasing morbidity and mortality. To control these diseases, research in rodent models that closely mimic the changes in humans is essential. This review will examine the adequacy of the many rodent models of metabolic syndrome to mimic the causes and progression of the disease in humans. The primary criterion will be whether a rodent model initiates all of the signs, especially obesity, diabetes, hypertension and dysfunction of the heart, blood vessels, liver and kidney, primarily by diet since these are the diet-induced signs in humans with metabolic syndrome. We conclude that the model that comes closest to fulfilling this criterion is the high carbohydrate, high fat-fed male rodent.
C1 [Panchal, Sunil K.; Brown, Lindsay] Univ So Queensland, Dept Biol & Phys Sci, Toowoomba, Qld 4350, Australia.
C3 University of Southern Queensland
RP Brown, L (corresponding author), Univ So Queensland, Dept Biol & Phys Sci, Toowoomba, Qld 4350, Australia.
EM lindsay.brown@usq.edu.au
OI Panchal, Sunil K/0000-0001-5464-3376
FU National Health and Medical Research Council of Australia; Prince
   Charles Hospital Foundation; Dr Red Nutraceuticals, Mt Nebo, Queensland,
   Australia
FX The authors' own studies were supported by grants from the National
   Health and Medical Research Council of Australia, The Prince Charles
   Hospital Foundation and Dr Red Nutraceuticals, Mt Nebo, Queensland,
   Australia.
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NR 152
TC 300
Z9 331
U1 0
U2 56
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1110-7243
EI 1110-7251
J9 J BIOMED BIOTECHNOL
JI J. Biomed. Biotechnol.
PY 2011
AR 351982
DI 10.1155/2011/351982
PG 14
WC Biotechnology & Applied Microbiology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Research & Experimental Medicine
GA 706QO
UT WOS:000286233100001
PM 21253582
OA Green Submitted, Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Bahreinian, S
   Ball, GDC
   Vander Leek, TK
   Colman, I
   McNeil, BJ
   Becker, AB
   Kozyrskyrj, AL
AF Bahreinian, Salma
   Ball, Geoff D. C.
   Vander Leek, Timothy K.
   Colman, Ian
   McNeil, Brian J.
   Becker, Allan B.
   Kozyrskyrj, Anita L.
TI Allostatic Load Biomarkers and Asthma in Adolescents
SO AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
LA English
DT Article
DE psychological stress; allostasis; bronchial asthma; pediatrics;
   biological markers
ID METABOLIC-SYNDROME; CHRONIC STRESS; INSULIN-RESISTANCE; CUMULATIVE RISK;
   CARDIOVASCULAR RISK; PUBERTAL CHANGES; OBESE CHILDREN; EARLY-LIFE;
   CHILDHOOD; HEALTH
AB Rationale: Allostatic load (AL), a novel measure of the physiologically dysregulated response of the body to stress, represents a biomarker of chronic stress exposure.
   Objectives: To determine whether preadolescent children with high AL are more susceptible to asthma as adolescents.
   Methods: This was a prospective evaluation of children recruited at 7 to 10 years of age in the nested case-control arm of the Study of Asthma, Genes and Environment and followed until 11 to 14 years of age. AL was measured using eight biomarkers: fasting glucose, total cholesterol, high-density lipoprotein cholesterol, dehydroepiandrosterone sulfate, cortisol, systolic and diastolic blood pressure, and waist-to-hip ratio. AL, created from the sum of biomarkers in a high-risk quartile, was related to prevalence and incidence of asthma using logistic regression.
   Measurements and Main Results: Among 352 participants followed until 11 to 14 years of age, prevalent asthma was four times more likely in boys with high (>3) versus low (<= 2) AL after adjusting for current asthma/atopy, age, ethnicity, parental history of asthma, and overweight status. Similar results were observed in the analysis of new-onset asthma in boys (adjusted odds ratio, 4.35; 95% confidence interval, 1.19-15.9). In girls, there were no associations between AL and asthma. In the analysis of a subset of biomarkers, combinations of total cholesterol, glucose, and cortisol were associated with similar or greater risk of asthma prevalence or onset in boys.
   Conclusions: AL and its biomarkers are associated with an increased likelihood of asthma in adolescent boys. The observed association between AL and asthma may be attributable to a combined subset of AL biomarkers.
C1 [Bahreinian, Salma; Ball, Geoff D. C.; Vander Leek, Timothy K.; Kozyrskyrj, Anita L.] Univ Alberta, Dept Pediat, Fac Med & Dent, Edmonton, AB, Canada.
   [Colman, Ian] Univ Ottawa, Dept Epidemiol & Community Med, Ottawa, ON, Canada.
   [McNeil, Brian J.] Univ Manitoba, Sch Med Rehabil, Dept Phys Therapy, Winnipeg, MB, Canada.
   [Becker, Allan B.] Univ Manitoba, Dept Pediat & Child Hlth, Fac Med, Winnipeg, MB R3T 2N2, Canada.
C3 University of Alberta; University of Ottawa; University of Manitoba;
   University of Manitoba
RP Bahreinian, S (corresponding author), Edmonton Clin Hlth Acad ECHA, 3-547,11405-87 Ave, Edmonton, AB T6G 1C9, Canada.
EM bahreini@ualberta.ca
RI Ball, Geoff/IZD-7107-2023; Colman, Ian/AFK-4708-2022; Kozyrskyj,
   Anita/JBS-5088-2023
OI Colman, Ian/0000-0001-5924-0277; Kozyrskyj, Anita/0000-0002-2869-9242
FU AllerGen NCE, Inc.; Canadian Institutes of Health Research; Women and
   Children's Health Research Institute in Edmonton; Alberta
   Innovates-Health Solutions; CIHR; Women and Children's Health Research
   Institute/Stollery Children's Hospital Foundation
FX Supported by AllerGen NCE, Inc., and the Canadian Institutes of Health
   Research new emerging team and operating grants, by a studentship from
   the Women and Children's Health Research Institute in Edmonton (S.B.),
   by Population Health Investigator Awards from Alberta Innovates-Health
   Solutions and New Investigator Awards from CIHR (G.D.C.B. and I.C.), and
   by the Women and Children's Health Research Institute/Stollery
   Children's Hospital Foundation (A.L.K.).
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NR 61
TC 40
Z9 48
U1 0
U2 17
PU AMER THORACIC SOC
PI NEW YORK
PA 25 BROADWAY, 18 FL, NEW YORK, NY 10004 USA
SN 1073-449X
EI 1535-4970
J9 AM J RESP CRIT CARE
JI Am. J. Respir. Crit. Care Med.
PD JAN 15
PY 2013
VL 187
IS 2
BP 144
EP 152
DI 10.1164/rccm.201201-0025OC
PG 9
WC Critical Care Medicine; Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Respiratory System
GA 075YY
UT WOS:000313924600010
PM 22955315
DA 2025-06-11
ER

PT J
AU Prather, H
   Cheng, J
AF Prather, Heidi
   Cheng, Jennifer
TI Relationship of Chronic Systemic Inflammation to Both Chronic
   Lifestyle-Related Diseases and Osteoarthritis: The Case for Lifestyle
   Medicine for Osteoarthritis
SO HSS JOURNAL
LA English
DT Article; Proceedings Paper
CT Hip Osteoarthritis Clinical Studies Conference
CY FEB 17-18, 2023
CL New York, NY
DE osteoarthritis; metabolic; lifestyle medicine; inflammation
ID C-REACTIVE PROTEIN; SOCIAL-ISOLATION; PHYSICAL INACTIVITY;
   MUSCULOSKELETAL PAIN; INSULIN-RESISTANCE; METABOLIC SYNDROME; SLEEP
   RESTRICTION; RISK-FACTOR; ANXIETY; LONELINESS
AB Systemic inflammation is a root cause of lifestyle-related chronic diseases and may also play a role in the development and progression of osteoarthritis (OA). Lifestyle medicine seeks to treat, prevent, and reverse lifestyle-related chronic disease via 6 pillars: nutrition, sleep health, stress management, physical activity, social connections, and risky behavior avoidance/reduction. This article presents a review of the literature in which we assess the connections between the 6 pillars of lifestyle medicine, chronic systemic inflammation, and OA. We also discuss the whole-person approach that lifestyle medicine interventions can provide to reduce chronic systemic inflammation and affect the development or progression of OA.
C1 [Prather, Heidi; Cheng, Jennifer] Hosp Special Surg, Dept Physiatry, New York, NY USA.
   [Prather, Heidi] Hosp Special Surg, Dept Physiatry, 535 East 70th St, New York, NY 10021 USA.
RP Prather, H (corresponding author), Hosp Special Surg, Dept Physiatry, 535 East 70th St, New York, NY 10021 USA.
EM pratherh@hss.edu
RI Prather, Heidi/AAN-8851-2021
FU Arthritis Foundation and Hospital for Special Surgery
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: The
   Arthritis Foundation and Hospital for Special Surgery funded the 2023
   Hip Osteoarthritis Clinical Studies Conference, with support from
   Stryker, Alexion, and Smith+Nephew.
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NR 75
TC 4
Z9 4
U1 2
U2 2
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1556-3316
EI 1556-3324
J9 HSS J
JI HSS J.
PD NOV
PY 2023
VL 19
IS 4
SI SI
BP 459
EP 466
DI 10.1177/15563316231193753
PG 8
WC Orthopedics; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Orthopedics; Surgery
GA W5IP3
UT WOS:001091964000012
PM 37937092
OA Green Published
DA 2025-06-11
ER

PT J
AU Ribeiro, MF
   Santos, AA
   Afonso, MB
   Rodrigues, PM
   Santos, SS
   Castro, RE
   Rodrigues, CMP
   Solá, S
AF Ribeiro, Maria F.
   Santos, Andre A.
   Afonso, Marta B.
   Rodrigues, Pedro M.
   Santos, Sonia Sa
   Castro, Rui E.
   Rodrigues, Cecilia M. P.
   Sola, Susana
TI Diet-dependent gut microbiota impacts on adult neurogenesis through
   mitochondrial stress modulation
SO BRAIN COMMUNICATIONS
LA English
DT Article
DE gut microbiome; high-fat choline-deficient diet; mitochondrial oxidative
   stress; neurogenesis; short-chain fatty acids
ID HIGH-FAT DIET; HIPPOCAMPAL NEUROGENESIS; DENTATE GYRUS; MOUSE MODEL;
   ANXIETY; DEPRESSION; HEALTH; CELLS; PROLIFERATION; DISRUPTION
AB The influence of dietary factors on brain health and mental function is becoming increasingly recognized. Similarly, mounting evidence supports a role for gut microbiota in modulating central nervous system function and behaviour. Still, the molecular mechanisms responsible for the impact of diet and associated microbiome in adult neurodegeneration are still largely unclear. In this study, we aimed to investigate whether and how changes in diet-associated microbiome and its metabolites impact on adult neurogenesis. Mice were fed a high-fat, choline-deficient diet, developing obesity and several features of the metabolic syndrome, including non-alcoholic steatohepatitis. Strikingly, our results showed, for the first time, that animals fed with this specific diet display premature increased neurogenesis, possibly exhausting the available neural stem cell pool for long-term neurogenesis processes. The high-fat, choline-deficient diet further induced neuroinflammation, oxidative stress, synaptic loss and cell death in different regions of the brain. Notably, this diet-favoured gut dysbiosis in the small intestine and cecum, up-regulating metabolic pathways of short-chain fatty acids, such as propionate and butyrate and significantly increasing propionate levels in the liver. By dissecting the effect of these two specific short-chain fatty acids in vitro, we were able to show that propionate and butyrate enhance mitochondrial biogenesis and promote early neurogenic differentiation of neural stem cells through reactive oxygen species- and extracellular signal-regulated kinases 1/2-dependent mechanism. More importantly, neurogenic niches of high-fat, choline-deficient-fed mice showed increased expression of mitochondrial biogenesis markers, and decreased mitochondrial reactive oxygen species scavengers, corroborating the involvement of this mitochondrial stress-dependent pathway in mediating changes of adult neurogenesis by diet. Altogether, our results highlight a mitochondria-dependent pathway as a novel mediator of the gut microbiota-brain axis upon dietary influences.
C1 [Rodrigues, Pedro M.] Univ Basque Country, UPV EHU, Donostia Univ Hosp, San Sebastian, Spain.
   [Ribeiro, Maria F.; Santos, Andre A.; Afonso, Marta B.; Rodrigues, Pedro M.; Santos, Sonia Sa; Castro, Rui E.; Rodrigues, Cecilia M. P.; Sola, Susana] Univ Lisbon, Fac Pharm, Res Inst Med iMed ULisboa, Lisbon, Portugal.
C3 University of Basque Country; University Hospital Donostia; Universidade
   de Lisboa
RP Rodrigues, CMP; Solá, S (corresponding author), Av Prof Gama Pinto, P-1649003 Lisbon, Portugal.
EM cmprodrigues@ff.ulisboa.pt; susana.sola@ff.ulisboa.pt
RI Ribeiro, Maria/A-3978-2017; Castro, Rui/AAG-4179-2021; Rodrigues,
   Pedro/M-6227-2017; Santos, Andre Anastacio/A-3313-2017; Sola,
   Susana/M-5251-2013; Sa Santos, Sonia/M-9196-2013; Castro,
   Rui/I-2975-2013; Pereira Rodrigues, Cecilia Maria/M-3572-2013; Afonso,
   Marta/N-5202-2017
OI Rodrigues, Pedro/0000-0001-6193-7436; Santos, Andre
   Anastacio/0000-0002-3248-1051; Sola, Susana/0000-0003-2036-797X; Sa
   Santos, Sonia/0000-0002-8207-3937; Castro, Rui/0000-0002-7417-0091;
   Pereira Rodrigues, Cecilia Maria/0000-0002-4829-754X; Afonso,
   Marta/0000-0003-3011-4941
FU Fundacao para a Ciencia e Tecnologia, Portugal [PTDC/MED-NEU/29650/2017,
   SFRH/BD/100674/2014]; Fundação para a Ciência e a Tecnologia
   [PTDC/MED-NEU/29650/2017, SFRH/BD/100674/2014] Funding Source: FCT
FX This work was supported by PTDC/MED-NEU/29650/2017 and
   SFRH/BD/100674/2014 from Fundacao para a Ciencia e Tecnologia, Portugal.
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NR 82
TC 33
Z9 34
U1 0
U2 30
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
EI 2632-1297
J9 BRAIN COMMUN
JI Brain Commun.
PY 2020
VL 2
IS 2
AR 165
DI 10.1093/braincomms/fcaa165
PG 20
WC Clinical Neurology; Neurosciences
WE Emerging Sources Citation Index (ESCI)
SC Neurosciences & Neurology
GA RM1PH
UT WOS:000639431800103
PM 33426525
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Cohen, BE
   Martires, KJ
   Ho, RS
AF Cohen, Brandon E.
   Martires, Kathryn J.
   Ho, Roger S.
TI Psoriasis and the Risk of Depression in the US Population National
   Health and Nutrition Examination Survey 2009-2012
SO JAMA DERMATOLOGY
LA English
DT Article
ID QUALITY-OF-LIFE; MYOCARDIAL-INFARCTION; CARDIOVASCULAR RISK; METABOLIC
   SYNDROME; PRIMARY-CARE; ANXIETY; VALIDATION; SEVERITY; DISEASE;
   QUESTIONNAIRE
AB IMPORTANCE Psoriasis is a risk factor for depression. Depression may also trigger or exacerbate psoriasis. The relationship between psoriasis and depression, however, remains to be fully explored.
   OBJECTIVE To investigate the association between psoriasis and major depression in the US population.
   DESIGN, SETTING, AND PARTICIPANTS Population-based study using participants in the National Health and Nutrition Examination Survey from 2009 through 2012.
   MAIN OUTCOMES AND MEASURES Diagnosis of major depression based on the Patient Health Questionnaire-9.
   RESULTS We identified 351 (2.8%) cases of psoriasis and 968 (7.8%) cases of major depression among 12 382 US citizens included in our study. Fifty-eight (16.5%) patients with psoriasis met criteria for a diagnosis of major depression. The mean (SD) Patient Health Questionnaire-9 score was significantly higher among patients with a history of psoriasis than those without psoriasis (4.54 [5.7] vs 3.22 [4.3], P < .001). Psoriasis was significantly associated with major depression, even after adjustment for sex, age, race, body mass index, physical activity, smoking history, alcohol use, history of myocardial infarction (MI), history of stroke, and history of diabetes mellitus (OR, 2.09 [95% CI, 1.41-3.11], P < .001). Interaction term analyses involving patients with a history of both psoriasis and a cardiovascular event, specifically MI or stroke, did not reveal a synergistically increased risk of major depression (psoriasis and MI: OR, 1.09 [95% CI, 0.28-3.60], P = .91; psoriasis and stroke: OR, 0.67 [95% CI, 0.12-3.66], P = .63). In adjusted multivariable models, the risk of major depression was not significantly different between patients with limited vs extensive psoriasis (OR, 0.66 [95% CI, 0.18-2.44], P = .53).
   CONCLUSIONS AND RELEVANCE Self-reported history of psoriasis was independently associated with major depression as assessed by a validated screening tool, even when controlling for comorbidities. History of cardiovascular event did not modify the risk of major depression for patients with psoriasis. The severity of psoriasis was unrelated to the risk of major depression. Therefore, all patients with psoriasis, regardless of severity, may be at risk for major depression.
C1 [Cohen, Brandon E.; Martires, Kathryn J.; Ho, Roger S.] NYU, Sch Med, Ronald O Perelman Dept Dermatol, 240 E 38th St,12th Floor, New York, NY USA.
C3 New York University
RP Ho, RS (corresponding author), NYU, Sch Med, Ronald O Perelman Dept Dermatol, 240 E 38th St,12th Floor, New York, NY USA.
EM roger.ho@nyumc.org
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NR 34
TC 120
Z9 122
U1 1
U2 13
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 2168-6068
EI 2168-6084
J9 JAMA DERMATOL
JI JAMA Dermatol.
PD JAN
PY 2016
VL 152
IS 1
BP 73
EP 79
DI 10.1001/jamadermatol.2015.3605
PG 7
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology
GA DE4AS
UT WOS:000370572200011
PM 26421371
OA Bronze
DA 2025-06-11
ER

PT J
AU Sonnino, R
   Ciccarelli, G
   Moffa, S
   Soldovieri, L
   Di Giuseppe, G
   Brunetti, M
   Cinti, F
   Di Piazza, E
   Gasbarrini, A
   Nista, EC
   Pontecorvi, A
   Giaccari, A
   Mezza, T
AF Sonnino, Rebecca
   Ciccarelli, Gea
   Moffa, Simona
   Soldovieri, Laura
   Di Giuseppe, Gianfranco
   Brunetti, Michela
   Cinti, Francesca
   Di Piazza, Eleonora
   Gasbarrini, Antonio
   Nista, Enrico C.
   Pontecorvi, Alfredo
   Giaccari, Andrea
   Mezza, Teresa
TI Exploring nutraceutical approaches linking metabolic syndrome and
   cognitive impairment
SO ISCIENCE
LA English
DT Review
ID POLYUNSATURATED FATTY-ACIDS; DIET-INDUCED OBESITY; VITAMIN-E; OXIDATIVE
   STRESS; DOCOSAHEXAENOIC ACIDS; ALZHEIMERS-DISEASE; RESVERATROL
   SUPPLEMENTATION; INSULIN-RESISTANCE; GENE-EXPRESSION; GUT MICROBIOTA
AB Metabolic syndrome (MetS) and mild cognitive impairment (MCI) are interconnected conditions sharing common pathological pathways, such as inflammation and oxidative stress, leading to the concept of "metaboliccognitive syndrome."This highlights their mutual influence and potential overlapping therapeutic strategies. Although lifestyle modifications remain essential, nutraceutical supplementation has emerged as a promising adjunct for the prevention and management of these preclinical conditions. This review examines clinical and translational evidence on commonly used nutraceuticals targeting shared pathophysiological mechanisms of MetS and MCI. By addressing inflammation, oxidative stress, and metabolic dysfunction, these supplements may offer a valuable approach to mitigating the progression and consequences of both conditions. Understanding their efficacy could provide practical tools to complement lifestyle changes, offering a more comprehensive strategy for managing metabolic-cognitive syndrome.
C1 [Sonnino, Rebecca; Ciccarelli, Gea; Soldovieri, Laura; Di Giuseppe, Gianfranco; Brunetti, Michela; Cinti, Francesca; Gasbarrini, Antonio; Pontecorvi, Alfredo; Giaccari, Andrea; Mezza, Teresa] Univ Cattolica Sacro Cuore, Dept Translat Med & Surg, Rome, Italy.
   [Sonnino, Rebecca; Ciccarelli, Gea; Moffa, Simona; Soldovieri, Laura; Di Giuseppe, Gianfranco; Brunetti, Michela; Cinti, Francesca; Di Piazza, Eleonora; Giaccari, Andrea] Fdn Policlin Univ A Gemelli IRCCS, Ctr Endocrine & Metab Dis, Rome, Italy.
   [Gasbarrini, Antonio; Nista, Enrico C.; Mezza, Teresa] Fdn Policlin Univ Gemelli IRCCS, CEMAD Digest Dis Ctr, Pancreas Unit, Internal Med & Gastroenterol Unit, Rome, Italy.
C3 Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli;
   Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli;
   Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli
RP Giaccari, A; Mezza, T (corresponding author), Univ Cattolica Sacro Cuore, Dept Translat Med & Surg, Rome, Italy.; Giaccari, A (corresponding author), Fdn Policlin Univ A Gemelli IRCCS, Ctr Endocrine & Metab Dis, Rome, Italy.; Mezza, T (corresponding author), Fdn Policlin Univ Gemelli IRCCS, CEMAD Digest Dis Ctr, Pancreas Unit, Internal Med & Gastroenterol Unit, Rome, Italy.
EM andrea.giaccari@unicatt.it; teresa.mezza@gmail.com
RI Di Giuseppe, Gianfranco/LGY-8829-2024; Pontecorvi, Alfredo/K-5146-2016;
   Gasbarrini, Antonio/NAZ-7603-2025; mezza, teresa/B-1856-2014
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NR 152
TC 0
Z9 0
U1 0
U2 0
PU CELL PRESS
PI CAMBRIDGE
PA 50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA
EI 2589-0042
J9 ISCIENCE
JI iScience
PD FEB 21
PY 2025
VL 28
IS 2
AR 111848
DI 10.1016/j.isci.2025.111848
PG 16
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA X3Y7F
UT WOS:001424750800001
PM 40008362
OA gold
DA 2025-06-11
ER

PT J
AU Lee, EB
   Warmann, G
   Dhir, R
   Ahima, RS
AF Lee, Edward B.
   Warmann, Genevieve
   Dhir, Ravindra
   Ahima, Rexford S.
TI Metabolic Dysfunction Associated with Adiponectin Deficiency Enhances
   Kainic Acid-Induced Seizure Severity
SO JOURNAL OF NEUROSCIENCE
LA English
DT Article
ID INDUCED STATUS EPILEPTICUS; PENTYLENETETRAZOLE-INDUCED SEIZURES; INDUCED
   INSULIN-RESISTANCE; MICE LACKING ADIPONECTIN; HIPPOCAMPAL-NEURONS;
   OXIDATIVE STRESS; GAMMA AGONIST; VALPROIC ACID; LEPTIN; EPILEPSY
AB Metabolic syndrome has deleterious effects on the CNS, and recent evidence suggests that obesity rates are higher at presentation in children who develop epilepsy. Adiponectin is secreted by adipose tissue and acts in the brain and peripheral organs to regulate glucose and lipid metabolism. Adiponectin deficiency predisposes toward metabolic syndrome, characterized by obesity, insulin resistance, impaired glucose tolerance, hyperlipidemia, and cardiovascular morbidity. To investigate the relationship between metabolic syndrome and seizures, wild-type C57BL/6J and adiponectin knock-out mice were fed a high-fat diet, followed by treatment with low doses of kainic acid to induce seizures. Adiponectin deficiency in mice fed a high-fat diet resulted in greater fat accumulation, impaired glucose tolerance, hyperlipidemia, increased seizure severity, and increased hippocampal pathology. In contrast, there were no adverse effects of adiponectin deficiency on metabolic phenotype or seizure activity in mice fed a normal (low-fat) chow diet. These findings demonstrate that metabolic syndrome modulates the outcome of seizures and brain injury.
C1 [Ahima, Rexford S.] Univ Penn, Dept Med, Div Endocrinol Diabet & Metab, Perelman Sch Med,Translat Res Ctr 12 104, Philadelphia, PA 19104 USA.
C3 University of Pennsylvania
RP Ahima, RS (corresponding author), Univ Penn, Dept Med, Div Endocrinol Diabet & Metab, Perelman Sch Med,Translat Res Ctr 12 104, 3400 Civ Ctr Blvd,Bldg 421, Philadelphia, PA 19104 USA.
EM ahima@mail.med.upenn.edu
RI Lee, Edward/AAU-8436-2021; Ahima, Rexford/W-1394-2019
FU NIH [RO1-DK-062348, PO1-DK-049210, T32-AG00255, K08-AG039510,
   P30-DK19525]
FX This study was supported by NIH Grants RO1-DK-062348 and PO1-DK-049210
   (R. S. A.) and T32-AG00255 and K08-AG039510 (E. B. L.). We thank Drs.
   John Q. Trojanowski and Virginia M.-Y. Lee for providing antibody
   reagents, and the University of Pennsylvania Diabetes and Endocrinology
   Research Center (DERC) Mouse Phenotyping, Physiology and Metabolism Core
   for body composition analysis (NIH Grant P30-DK19525).
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NR 42
TC 44
Z9 46
U1 2
U2 7
PU SOC NEUROSCIENCE
PI WASHINGTON
PA 11 DUPONT CIRCLE, NW, STE 500, WASHINGTON, DC 20036 USA
SN 0270-6474
J9 J NEUROSCI
JI J. Neurosci.
PD OCT 5
PY 2011
VL 31
IS 40
BP 14361
EP 14366
DI 10.1523/JNEUROSCI.3171-11.2011
PG 6
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 832LD
UT WOS:000295805500033
PM 21976521
OA hybrid, Green Accepted, Green Published
DA 2025-06-11
ER

PT J
AU Zavisic, G
   Ristic, S
   Rikalovic, M
   Petkovic, B
   Jankovic, D
   Vukadinovic, A
   Petricevic, S
AF Zavisic, Gordana
   Ristic, Slavica
   Rikalovic, Milena
   Petkovic, Branka
   Jankovic, Drina
   Vukadinovic, Aleksandar
   Petricevic, Sasa
TI Beneficial effects of probiotic supplementation on glucose and
   triglycerides in a mouse model of metabolic syndrome
SO JOURNAL OF FUNCTIONAL FOODS
LA English
DT Article
DE Lactobacillus spp; Biochemical parameters; Metabolic syndrome
ID HIGH-FAT; MANAGEMENT; PREBIOTICS; STRESS
AB The present study aimed to examine the effect of Lactobacillus rhamnosus Rosell 11 and Lactobacillus helveticus Rosell 52 on glucose (blood level and tolerance), lipids (cholesterol and triglycerides), transaminases (AST and ALT), ALP, urea, and creatinine, along with body weight, food intake, liquid consumption, and gross pathology in a mouse model of metabolic syndrome. Male C57BL/6J mice were fed a high-fat high-sucrose diet and treated by oral gavage with a probiotic mixture in three different concentrations (10(7), 10(8), and 10(9) CFU/mL) once daily for 2 months. Probiotic supplementation, particularly at a concentration of 10(9) CFU, significantly decreased blood glucose and serum triglyceride levels, improved glucose tolerance, and promoted body weight loss in mice fed a high-fat high-sucrose diet. According to the obtained results, probiotic supplementation is useful for controlling glucose and triglyceride levels and could be used as an adjunctive therapeutic approach in patients with metabolic syndrome.
C1 [Zavisic, Gordana] Univ Business Acad Novi Sad, Fac Pharm, Novi Sad, Serbia.
   [Ristic, Slavica; Petricevic, Sasa] Univ Belgrade, Inst Med & Clin Biochem, Fac Med, Belgrade, Serbia.
   [Rikalovic, Milena] Singidunum Univ, Environm & Sustainable Dev, Belgrade, Serbia.
   [Petkovic, Branka] Univ Belgrade, Inst Biol Res Sinisa Stankov, Natl Inst Republ Serbia, Dept Neurophysiol, Belgrade, Serbia.
   [Jankovic, Drina; Vukadinovic, Aleksandar] Univ Belgrade, Vinca Inst Nucl Sci, Natl Inst Republ Serbia, Belgrade, Serbia.
C3 University of Novi Sad; University of Belgrade; University of Belgrade;
   University of Belgrade
RP Zavisic, G (corresponding author), Univ Business Acad Novi Sad, Fac Pharm, Novi Sad, Serbia.
EM gordana.zavisic@faculty-pharmacy.com
RI Rikalovic, Milena/HCI-8373-2022; Petkovic, Branka/GNH-5614-2022
OI Petkovic, Branka/0000-0001-7817-4092; Petricevic,
   Sasa/0000-0002-2837-5934; Rikalovic, Milena/0000-0002-1809-5461;
   Jankovic, Drina/0000-0003-3938-2790; Ristic, Slavica/0000-0002-6983-4412
FU Ministry of Education, Science and Technological Development of the
   Republic of Serbia through funding the VINCENT Center of Excellence
   [451-03-68/2022-14/200017, 451-03-68/2022-14/200007]
FX The research was supported by the Ministry of Education, Science and
   Technological Development of the Republic of Serbia [Contract numbers:
   451-03-68/2022-14/200017 and 451-03-68/2022-14/200007] and through
   funding the VINCENT Center of Excellence.
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NR 33
TC 6
Z9 6
U1 3
U2 12
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1756-4646
EI 2214-9414
J9 J FUNCT FOODS
JI J. Funct. Food.
PD AUG
PY 2022
VL 95
AR 105167
DI 10.1016/j.jff.2022.105167
EA JUL 2022
PG 7
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA 5B7QD
UT WOS:000863764500004
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Frisbee, JC
   Goodwill, AG
   Frisbee, SJ
   Butcher, JT
   Brock, RW
   Olfert, IM
   DeVallance, ER
   Chantler, PD
AF Frisbee, Jefferson C.
   Goodwill, Adam G.
   Frisbee, Stephanie J.
   Butcher, Joshua T.
   Brock, Robert W.
   Olfert, I. Mark
   DeVallance, Evan R.
   Chantler, Paul D.
TI Distinct temporal phases of microvascular rarefaction in skeletal muscle
   of obese Zucker rats
SO AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
LA English
DT Article
DE skeletal muscle perfusion; vascular remodeling; vascular reactivity;
   rodent models of obesity; nitric oxide bioavailability; chronic
   inflammation
ID METABOLIC SYNDROME; RISK-FACTORS; CARDIOVASCULAR-DISEASE; RESISTANCE
   ARTERIES; INSULIN-RESISTANCE; REDUCED PO2; HYPERTENSION; MODELS; INJURY;
   IMPACT
AB Evolution of metabolic syndrome is associated with a progressive reduction in skeletal muscle microvessel density, known as rarefaction. Although contributing to impairments to mass transport and exchange, the temporal development of rarefaction and the contributing mechanisms that lead to microvessel loss are both unclear and critical areas for investigation. Although previous work suggests that rarefaction severity in obese Zucker rats (OZR) is predicted by the chronic loss of vascular nitric oxide (NO) bioavailability, we have determined that this hides a biphasic development of rarefaction, with both early and late components. Although the total extent of rarefaction was well predicted by the loss in NO bioavailability, the early pulse of rarefaction developed before a loss of NO bioavailability and was associated with altered venular function (increased leukocyte adhesion/rolling), and early elevation in oxidant stress, TNF-alpha levels, and the vascular production of thromboxane A2 (TxA2). Chronic inhibition of TNF-alpha blunted the severity of rarefaction and also reduced vascular oxidant stress and TxA2 production. Chronic blockade of the actions of TxA2 also blunted rarefaction, but did not impact oxidant stress or inflammation, suggesting that TxA2 is a downstream outcome of elevated reactive oxygen species and inflammation. If chronic blockade of TxA2 is terminated, microvascular rarefaction in OZR skeletal muscle resumes, but at a reduced rate despite low NO bioavailability. These results suggest that therapeutic interventions against inflammation and TxA2 under conditions where metabolic syndrome severity is moderate or mild may prevent the development of a condition of accelerated microvessel loss with metabolic syndrome.
C1 [Frisbee, Jefferson C.; Goodwill, Adam G.; Butcher, Joshua T.; Brock, Robert W.] W Virginia Univ, Hlth Sci Ctr, Dept Physiol & Pharmacol, Morgantown, WV 26506 USA.
   [Frisbee, Stephanie J.] W Virginia Univ, Hlth Sci Ctr, Dept Hlth Policy Management & Leadership, Morgantown, WV 26506 USA.
   [Olfert, I. Mark; DeVallance, Evan R.; Chantler, Paul D.] W Virginia Univ, Hlth Sci Ctr, Div Exercise Physiol, Morgantown, WV 26506 USA.
   [Frisbee, Jefferson C.; Goodwill, Adam G.; Frisbee, Stephanie J.; Butcher, Joshua T.; Brock, Robert W.; Olfert, I. Mark; DeVallance, Evan R.; Chantler, Paul D.] W Virginia Univ, Hlth Sci Ctr, Ctr Cardiovasc & Resp Sci, Morgantown, WV 26506 USA.
C3 West Virginia University; West Virginia University; West Virginia
   University; West Virginia University
RP Frisbee, JC (corresponding author), W Virginia Univ, Ctr Cardiovasc & Resp Sci, Robert C Byrd Hlth Sci Ctr, Sch Med,Dept Physiol & Pharmacol, POB 9105, Morgantown, WV 26505 USA.
EM jefrisbee@hsc.wvu.edu
RI Butcher, Joshua/ABH-7212-2022; Goodwill, Adam/N-4889-2016
OI Frisbee, Stephanie/0000-0003-1526-1839; Goodwill,
   Adam/0000-0003-3701-3713; Frisbee, Jefferson/0000-0003-2751-0599;
   Butcher, Joshua/0000-0002-7341-1949
FU American Heart Association [IRG 14330015, PRE 16850005, EIA 0740129N];
   National Institutes of Health [RR-2865AR, P20-RR-016477]
FX This study was supported by the American Heart Association (IRG
   14330015, PRE 16850005, EIA 0740129N) and the National Institutes of
   Health (RR-2865AR; P20-RR-016477).
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NR 54
TC 33
Z9 39
U1 0
U2 4
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0363-6135
EI 1522-1539
J9 AM J PHYSIOL-HEART C
JI Am. J. Physiol.-Heart Circul. Physiol.
PD DEC 15
PY 2014
VL 307
IS 12
BP H1714
EP H1728
DI 10.1152/ajpheart.00605.2014
PG 15
WC Cardiac & Cardiovascular Systems; Physiology; Peripheral Vascular
   Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Physiology
GA AW7YR
UT WOS:000346478200004
PM 25305181
OA Green Published
DA 2025-06-11
ER

PT J
AU Mao, XQ
   Ait-Aissa, K
   Lagrange, J
   Youcef, G
   Louis, H
AF Mao, Xianqing
   Ait-Aissa, Karima
   Lagrange, Jeremy
   Youcef, Gina
   Louis, Huguette
TI Hypertension, hypercoagulability and the metabolic syndrome: A cluster
   of risk factors for cardiovascular disease
SO BIO-MEDICAL MATERIALS AND ENGINEERING
LA English
DT Article; Proceedings Paper
CT 4th China-France Biotherapy and Regenerative Medicine International
   Symposium
CY JUN 18-19, 2011
CL Wuhan, PEOPLES R CHINA
DE Hypertension; hypercoagulability; metabolic syndrome; animal model
ID ACTIVATOR INHIBITOR TYPE-1; BLOOD-PRESSURE; ANGIOTENSIN-II;
   INSULIN-RESISTANCE; AT(1) RECEPTOR; ADIPOSE-TISSUE; ANIMAL-MODEL;
   ARTERIAL THROMBOSIS; OXIDATIVE STRESS; GENE-EXPRESSION
AB Cardiovascular disease (CVD) is one of the main causes of mortality in the world representing around 30% of all deaths. It constitutes also an important factor in morbidity and incapacity. There are several related CVD risk factors such as hypertension, metabolic syndrome (MetS) and hypercoagulability. The exact mechanisms that underlie the relation between those factors and CVD are not sufficiently known yet; pathogenic explanations are lacking also for the mechanisms relating metabolic factors to insulin resistance (IR) and the association with the development of atherosclerosis and thrombosis. The possible links between hypertension, hemostasis alterations and MetS are examined in this report.
C1 [Louis, Huguette] INSERM, Fac Med, U961, F-54500 Vandoeuvre Les Nancy, France.
   Nancy Univ, Nancy, France.
C3 Institut National de la Sante et de la Recherche Medicale (Inserm);
   Universite de Lorraine; Universite de Lorraine
RP Louis, H (corresponding author), INSERM, Fac Med, U961, 9 Ave Foret Haye, F-54500 Vandoeuvre Les Nancy, France.
EM huguette.louis@inserm.fr
RI Lagrange, Jeremy/AAB-4505-2020
OI Ait Aissa, Karima/0000-0002-7133-4767; Lagrange,
   Jeremy/0000-0002-0811-565X
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NR 110
TC 13
Z9 15
U1 0
U2 10
PU IOS PRESS
PI AMSTERDAM
PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS
SN 0959-2989
EI 1878-3619
J9 BIO-MED MATER ENG
JI Bio-Med. Mater. Eng.
PY 2012
VL 22
IS 1-3
BP 35
EP 48
DI 10.3233/BME-2012-0688
PG 14
WC Engineering, Biomedical; Materials Science, Biomaterials
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Engineering; Materials Science
GA 970HN
UT WOS:000306119100006
PM 22766701
DA 2025-06-11
ER

PT J
AU Ferder, L
   Ferder, MD
   Inserra, F
AF Ferder, Leon
   Ferder, Marcelo Damian
   Inserra, Felipe
TI The Role of High-Fructose Corn Syrup in Metabolic Syndrome and
   Hypertension
SO CURRENT HYPERTENSION REPORTS
LA English
DT Article
DE High fructose corn syrup; HFCS; Cardiovascular disease; Hypertension;
   Dyslipidemia; Metabolic syndrome
ID INDUCED INSULIN-RESISTANCE; RENIN-ANGIOTENSIN SYSTEM; CHRONIC
   KIDNEY-DISEASE; DE-NOVO LIPOGENESIS; OXIDATIVE STRESS; DIETARY FRUCTOSE;
   NITRIC-OXIDE; FATTY LIVER; CONSUMPTION; RISK
AB Obesity and related diseases are an important and growing health concern in the United States and around the world. Soft drinks and other sugar-sweetened beverages are now the primary sources of added sugars in Americans' diets. The metabolic syndrome is a cluster of common pathologies, including abdominal obesity linked to an excess of visceral fat, fatty liver, insulin resistance, hyperinsulinemia, dyslipidemia, and hypertension. Trends in all of these alterations are related to the consumption of dietary fructose and the introduction of high-fructose corn syrup (HFCS) as a sweetener in soft drinks and other foods. Experimental and clinical evidence suggests a progressive association between HFCS consumption, obesity, and the other injury processes. However, experimental HFCS consumption seems to produce some of the changes associated with metabolic syndrome even without increasing the body weight. Metabolic damage associated with HFCS probably is not limited to obesity-pathway mechanisms.
C1 [Ferder, Leon] Ponce Sch Med, Dept Physiol & Pharmacol, Ponce, PR 00716 USA.
   [Ferder, Marcelo Damian; Inserra, Felipe] Univ Buenos Aires, Sch Med, Dept Pathol, Inst Cardiovasc Pathophysiol, Buenos Aires, DF, Argentina.
C3 University of Buenos Aires; Instituto Cardiovascular de Buenos Aires
   (ICBA)
RP Ferder, L (corresponding author), Ponce Sch Med, Dept Physiol & Pharmacol, 395 Zona Ind Reparada 2, Ponce, PR 00716 USA.
EM leferder@psm.edu; mardfer@hotmail.com; felinserra@yahoo.com.ar
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NR 60
TC 105
Z9 114
U1 2
U2 68
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1522-6417
EI 1534-3111
J9 CURR HYPERTENS REP
JI Curr. Hypertens. Rep.
PD APR
PY 2010
VL 12
IS 2
BP 105
EP 112
DI 10.1007/s11906-010-0097-3
PG 8
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 596XR
UT WOS:000277719600010
PM 20424937
DA 2025-06-11
ER

PT J
AU Grimaldi, PA
AF Grimaldi, Paul A.
TI Metabolic and nonmetabolic regulatory functions of peroxisome
   proliferator-activated receptor β
SO CURRENT OPINION IN LIPIDOLOGY
LA English
DT Review
DE inflammation; lipid metabolism; metabolic syndrome; oxidative stress
ID ENDOTHELIAL PROGENITOR CELLS; PPAR-DELTA; SKELETAL-MUSCLE;
   INSULIN-RESISTANCE; PHARMACOLOGICAL ACTIVATION; CYTOKINE PRODUCTION;
   ACID OXIDATION; BETA/DELTA; PGC-1-ALPHA; EXPRESSION
AB Purpose of review
   This review focuses on the emerging knowledge about peroxisome proliferator-activated receptor beta regulatory functions on metabolism, inflammation, and cellular stress.
   Recent findings
   Recent publications have confirmed the important roles of peroxisome proliferator-activated receptor beta in adaptive metabolic responses of skeletal muscle and have also implicated the nuclear receptor in the regulation of inflammation and oxidative stress in various tissues. The mechanisms implicated in these effects have been partially elucidated.
   Summary
   Peroxisome proliferator-activated receptors mediate the transcriptional effects of fatty acids and fatty acid derivatives and regulate many physiological functions, including metabolism and development. Use of potent and specific agonists revealed that activation of peroxisome proliferator-activated receptor beta efficiently reverses some metabolic syndrome-associated abnormalities by affecting metabolic, inflammatory, and oxidative stress responses in several tissues through both genomic and nongenomic modes of action.
C1 [Grimaldi, Paul A.] Fac Med Nice, INSERM, U907, F-06107 Nice, France.
   [Grimaldi, Paul A.] Univ Nice Sophia Antipolis, Nice, France.
C3 Institut National de la Sante et de la Recherche Medicale (Inserm);
   Universite Cote d'Azur; Universite Cote d'Azur
RP Grimaldi, PA (corresponding author), Fac Med Nice, INSERM, U907, 28 Ave Valombrose, F-06107 Nice, France.
EM grimaldi@unice.fr
FU Institut National de la Sante et de la Recherche Medicale; University of
   Nice-Sophia Antipolis; Fondation Coeur et Arteres (FCA) [07T3A]
FX The work done in the author's laboratory was supported by the Institut
   National de la Sante et de la Recherche Medicale, the University of
   Nice-Sophia Antipolis, and the Fondation Coeur et Arteres (FCA 07T3A).
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NR 46
TC 24
Z9 29
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0957-9672
J9 CURR OPIN LIPIDOL
JI Curr. Opin. Lipidology
PD JUN
PY 2010
VL 21
IS 3
BP 186
EP 191
DI 10.1097/MOL.0b013e32833884a4
PG 6
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism; Peripheral
   Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism;
   Cardiovascular System & Cardiology
GA 601ZG
UT WOS:000278106300004
PM 20480546
DA 2025-06-11
ER

PT J
AU Dongiovanni, P
   Fracanzani, AL
   Fargion, S
   Valenti, L
AF Dongiovanni, Paola
   Fracanzani, Anna Ludovica
   Fargion, Silvia
   Valenti, Luca
TI Iron in fatty liver and in the metabolic syndrome: A promising
   therapeutic target
SO JOURNAL OF HEPATOLOGY
LA English
DT Review
DE Iron; Insulin resistance; Nonalcoholic fatty liver disease; Metabolic
   syndrome; Vascular damage; Hereditary hemochromatosis; Nonalcoholic
   steatohepatitis; Oxidative stress
ID CORONARY-HEART-DISEASE; TUMOR-NECROSIS-FACTOR; DENSITY-LIPOPROTEIN
   CHOLESTEROL; PERIPHERAL ARTERIAL-DISEASE; INSULIN-RESISTANCE; OXIDATIVE
   STRESS; SERUM FERRITIN; HEPATIC IRON; HFE MUTATIONS; NONALCOHOLIC
   STEATOHEPATITIS
AB The dysmetabolic iron overload syndrome (DIOS) is now a frequent finding in the general population, as is detected in about one third of patients with nonalcoholic fatty liver disease (NAFLD) and the metabolic syndrome. The pathogenesis is related to altered regulation of iron transport associated with steatosis, insulin resistance, and subclinical inflammation, often in the presence of predisposing genetic factors. Evidence is accumulating that excessive body iron plays a causal role in insulin resistance through still undefined mechanisms that probably involve a reduced ability to burn carbohydrates and altered function of adipose tissue. Furthermore, DIOS may facilitate the evolution to type 2 diabetes by altering beta-cell function, the progression of cardiovascular disease by contributing to the recruitment and activation of macrophages within arterial lesions, and the natural history of liver disease by inducing oxidative stress in hepatocytes, activation of hepatic stellate cells, and malignant transformation by promotion of cell growth and DNA damage.
   Based on these premises, the association among DIOS, metabolic syndrome, and NAFLD is being investigated as a new risk factor to predict the development of overt cardiovascular and hepatic diseases, and possibly hepatocellular carcinoma, but most importantly, represents also a treatable condition. Indeed, iron depletion, most frequently achieved by phlebotomy, has been shown to decrease metabolic alterations and liver enzymes in controlled studies in NAFLD. Additional studies are warranted to evaluate the potential of iron reductive therapy on hard clinical outcomes in patients with DIOS. (C) 2011 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
C1 [Valenti, Luca] Univ Milan, Dept Internal Med, Fdn IRCCS Ca Granda Osped Maggiore Policlin, Ctr Malattie Metabol Fegato, I-20122 Milan, Italy.
C3 IRCCS Ca Granda Ospedale Maggiore Policlinico; University of Milan
RP Valenti, L (corresponding author), Univ Milan, Dept Internal Med, Fdn IRCCS Ca Granda Osped Maggiore Policlin, Ctr Malattie Metabol Fegato, Via F Sforza 35, I-20122 Milan, Italy.
EM luca.valenti@unimi.it
RI Dongiovanni, Paola/AAC-9965-2019; Valenti, Luca/B-3695-2009; Fracanzani,
   Anna Ludovica/J-8986-2018
OI Valenti, Luca/0000-0001-8909-0345; Fracanzani, Anna
   Ludovica/0000-0001-5918-0171; Dongiovanni, Paola/0000-0003-4343-7213
FU Bando Giovani Ricercatori; Ministero della Salute e delle Politiche
   Sociali, Universita degli Studi di Milano [GR-2007-683265, 2009-ATE0087]
FX Bando Giovani Ricercatori 2007, Ministero della Salute e delle Politiche
   Sociali (GR-2007-683265), PUR 10% 2009 (2009-ATE0087) Universita degli
   Studi di Milano to L.V.
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NR 153
TC 278
Z9 300
U1 1
U2 41
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0168-8278
EI 1600-0641
J9 J HEPATOL
JI J. Hepatol.
PD OCT
PY 2011
VL 55
IS 4
BP 920
EP 932
DI 10.1016/j.jhep.2011.05.008
PG 13
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 829WV
UT WOS:000295617500028
PM 21718726
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Zhu, ZQ
   Cao, F
   Li, XZ
AF Zhu, Ziqiang
   Cao, Fang
   Li, Xiaozhong
TI Epigenetic Programming and Fetal Metabolic Programming
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Review
DE epigenetic programming; fetal metabolic programming; metabolic syndrome;
   obesity; insulin resistance; adverse intrauterine environment
ID HIGH-FAT DIET; WIDE DNA METHYLATION; EXPOSURE IN-UTERO; GESTATIONAL
   DIABETES-MELLITUS; BETA-CELL FUNCTION; ENDOPLASMIC-RETICULUM STRESS;
   MATERNAL INSULIN-RESISTANCE; GENE-EXPRESSION; BIRTH-WEIGHT; CORD BLOOD
AB Fetal metabolic programming caused by the adverse intrauterine environment can induce metabolic syndrome in adult offspring. Adverse intrauterine environment introduces fetal long-term relatively irreversible changes in organs and metabolism, and thus causes fetal metabolic programming leading metabolic syndrome in adult offspring. Fetal metabolic programming of obesity and insulin resistance plays a key role in this process. The mechanism of fetal metabolic programming is still not very clear. It is suggested that epigenetic programming, also induced by the adverse intrauterine environment, is a critical underlying mechanism of fetal metabolic programming. Fetal epigenetic programming affects gene expression changes and cellular function through epigenetic modifications without DNA nucleotide sequence changes. Epigenetic modifications can be relatively stably retained and transmitted through mitosis and generations, and thereby induce the development of metabolic syndrome in adult offspring. This manuscript provides an overview of the critical role of epigenetic programming in fetal metabolic programming.
C1 [Zhu, Ziqiang; Li, Xiaozhong] Soochow Univ, Childrens Hosp, Suzhou, Peoples R China.
   [Zhu, Ziqiang; Cao, Fang] Nanjing Med Univ, Changzhou Matern & Child Hlth Care Hosp, Changzhou, Peoples R China.
C3 Soochow University - China; Nanjing Medical University
RP Li, XZ (corresponding author), Soochow Univ, Childrens Hosp, Suzhou, Peoples R China.
EM answercn@163.com
RI Zhu, Ziqiang/AAT-6345-2021
OI Zhu, Ziqiang/0000-0001-9190-9866
FU Jiangsu Commission of Health [F201439, QNRC305]; Changzhou Commission of
   Health [QN201724]
FX This study was supported by grants from the Jiangsu Commission of Health
   (F201439, QNRC305) and the Changzhou Commission of Health (QN201724).
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NR 195
TC 95
Z9 99
U1 6
U2 35
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD DEC 3
PY 2019
VL 10
AR 764
DI 10.3389/fendo.2019.00764
PG 15
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA JW5FK
UT WOS:000503077200001
PM 31849831
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Guo, Y
   Xu, MM
   Zhang, JL
   Hu, QC
   Zhou, ZK
   Wei, ZR
   Yan, J
   Chen, Y
   Lyu, JX
   Shao, XQ
   Wang, Y
   Guo, JM
   Wei, YL
AF Guo, Yu
   Xu, Mingmin
   Zhang, Jialei
   Hu, Qingchuan
   Zhou, Zhengkun
   Wei, Zeren
   Yan, Jian
   Chen, Yue
   Lyu, Jianxuan
   Shao, Xiaoqian
   Wang, Ying
   Guo, Jiamei
   Wei, Yulong
TI The effect of Three-Circle Post Standing
   (Zhanzhuang) Qigong on the physical and psychological well-being
   of college students Study protocol for a randomized controlled trial
SO MEDICINE
LA English
DT Article
DE college students; physical and psychological health; Qigong state of
   oneness with 3 adjustments; randomized controlled trial; Three-Circle
   Post Standing Qigong
ID QUALITY-OF-LIFE; HEALTH-RISK-BEHAVIORS; MENTAL-HEALTH; TAI-CHI;
   UNIVERSITY-STUDENTS; SEDENTARY BEHAVIOR; METABOLIC SYNDROME;
   BODY-COMPOSITION; CANCER-PATIENTS; CHRONIC-FATIGUE
AB Background: The physical and mental health of college students tends to continuously decline around the world due to lifestyle or behavior habits changes, and pervasive presence of the Internet. Thus it is urgent to improve their health in college life. As a traditional Qigong form is practiced mainly in a standing posture. Three-Circle Post Standing Qigong (TCPSQ) is suitable for regular practicing and has beneficial effects on improving the physiological function and psychological emotion by adjusting body, breathing, and mind. The aim of the 3 adjustments is to achieve a state of harmonious unity-integrating these adjustments into "one." In this study protocol article, we will systematically explore the effectiveness and safety, feasibility of TCPSQ on physical and psychological outcomes of the college students and deeply understand the state of harmonious unity-integrating adjustments of body, breath, and mind into "one."
   Method/design: We will conduct a randomized, assessor, and statistician blinded, parallel-controlled trial comparing the beneficial effect of TCPSQ in college students. A total of 80 eligible college students from the Beijing University of Chinese Medicine (BUCM) will be recruited and randomly allocated into TCPSQ training or unaltered lifestyle control group according 1: 1 allocation ratio with allocation concealment. TCPSQ intervention will last 10 weeks. The study period is 18 weeks including a 10-week supervised intervention and a 8-week follow-up. The relevant physical and psychological outcomes, adverse events, and safety will be evaluated at baseline, 6 weeks (at the mid-point of intervention), 11 weeks (at the end of intervention), and 19 weeks (after the 8-week follow-up period) by blinded independent outcome assessors.
   Discussion: This is the first randomized controlled trial protocol from the perspective of Qigong connotation to systematically investigate the effect of TCPSQ for the physical and mental health of a college student population. If the results in our study prove a significant intervention effect, this would provide preliminary higher-quality evidence and establish an optimal guidance for the application of TCPSQ exercise program among a college student population.
   Ethics and dissemination: The study was approved by the ethics committee of the Beijing University of Chinese Medicine (approval number: 2018BZHYLL0109). A SPIRIT checklist is available for this protocol. The trial was registered in Chinese Clinical Trial Registry (WHO ICTRP member). Registration number: ChiCTR-BON-17010840.
C1 [Guo, Yu; Hu, Qingchuan; Wei, Zeren; Yan, Jian; Chen, Yue; Lyu, Jianxuan; Wang, Ying; Guo, Jiamei; Wei, Yulong] Beijing Univ Chinese Med, Sch Acupuncture Moxibust & Tuina, 11 Bei San Huan Dong Lu, Beijing 100029, Peoples R China.
   [Guo, Yu; Zhang, Jialei; Hu, Qingchuan; Yan, Jian; Chen, Yue; Shao, Xiaoqian] Ovat Hlth Sci & Technol Co Ltd, ENN Grp, Langfang, Peoples R China.
   [Xu, Mingmin] Chengdu Univ Tradit Chinese Med, Sch Acupuncture Moxibust & Tuina, Chengdu, Sichuan, Peoples R China.
   [Zhou, Zhengkun] World Federat Chinese Med Soc, Int Liaison Dept, Beijing, Peoples R China.
C3 Beijing University of Chinese Medicine; Chengdu University of
   Traditional Chinese Medicine
RP Wei, YL (corresponding author), Beijing Univ Chinese Med, Sch Acupuncture Moxibust & Tuina, 11 Bei San Huan Dong Lu, Beijing 100029, Peoples R China.
EM wylbucm@163.com
FU National Natural Science Foundation of China [81674043]
FX This work was supported by the National Natural Science Foundation of
   China (No. 81674043).
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NR 107
TC 6
Z9 6
U1 15
U2 70
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD SEP
PY 2018
VL 97
IS 38
AR e12323
DI 10.1097/MD.0000000000012323
PG 14
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA GZ4BX
UT WOS:000449338200033
PM 30235685
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Mommersteeg, PMC
   Kupper, N
   Denollet, J
AF Mommersteeg, Paula M. C.
   Kupper, Nina
   Denollet, Johan
TI Type D personality is associated with increased metabolic syndrome
   prevalence and an unhealthy lifestyle in a cross-sectional Dutch
   community sample
SO BMC PUBLIC HEALTH
LA English
DT Article
ID D SCALE DS14; CARDIOVASCULAR-DISEASE; HEART-DISEASE; NEGATIVE
   AFFECTIVITY; SOCIAL INHIBITION; YOUNG-ADULTS; RISK-FACTORS; DEPRESSION;
   PATTERNS; CORTISOL
AB Background: People with Type D-Distressed-personality have a general tendency towards increased negative affectivity (NA), while at the same time inhibiting these emotions in social situations (SI). Type D personality is associated with an increased risk of adverse outcomes in patients with cardiovascular disease. Whether Type D personality is a cardiovascular risk factor in healthy populations remains to be investigated. In the present study, the relations between Type D personality and classical cardiovascular risk factors, i.e. metabolic syndrome and lifestyle were investigated in a Dutch community sample.
   Methods: In a cross-sectional study 1592 participants were included, aged 20-80 years. Metabolic syndrome was defined by self-report, following the International Diabetes Federation-IDF-guidelines including an increased waist circumference, dyslipidemia, hypertension, and diabetes. In addition lifestyle factors smoking, alcohol use, exercise and dietary habits were examined. Metabolic syndrome prevalence was stratified by Type D personality (a high score on both NA and SI), lifestyle and confounders age, gender, having a partner, higher education level, cardiac history, family history of cardiovascular disease.
   Results: Metabolic syndrome was more prevalent in persons with a Type D personality (13% vs. 6%). Persons with Type D personality made poorer lifestyle choices, adhered less to the physical activity norm (OR = 1.5, 95% CI = 1.1-2.0, p = .02), had a less varied diet (OR = 0.50, 95% CI = 0.40-0.70, p < .0005), and were less likely to restrict their fat intake (OR = 0.70, 95% CI = 0.50-0.90, p = .01). Type D personality was related to a twofold increased risk of metabolic syndrome (OR = 2.2, 95% CI = 1.2-4.0, p = .011), independent of lifestyle factors and confounders.
   Conclusions: Type D personality is related to an increased prevalence of metabolic syndrome and unhealthy lifestyle, which suggests both behavioral and biological vulnerability for development of cardiovascular disorders
C1 [Mommersteeg, Paula M. C.; Kupper, Nina; Denollet, Johan] Tilburg Univ, Dept Med Psychol, CoRPS Ctr Res Psychol Somat Dis, Tilburg, Netherlands.
C3 Tilburg University
RP Mommersteeg, PMC (corresponding author), Tilburg Univ, Dept Med Psychol, CoRPS Ctr Res Psychol Somat Dis, Tilburg, Netherlands.
EM P.M.C.Mommersteeg@uvt.nl
RI Mommersteeg, Paula/AAB-7801-2019; Kupper, Nina/B-6337-2011
FU Netherlands Organization for Scientific Research (NWO, The Hague, The
   Netherlands) [453-04-004]
FX We gratefully acknowledge our research assistants for their efforts in
   data collection and data entering. This research was partly funded by a
   VICI grant (#453-04-004) from the Netherlands Organization for
   Scientific Research (NWO, The Hague, The Netherlands) awarded to Dr.
   Johan Denollet. All authors declare that there is no conflict of
   interest.
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NR 52
TC 81
Z9 87
U1 1
U2 29
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2458
J9 BMC PUBLIC HEALTH
JI BMC Public Health
PD NOV 19
PY 2010
VL 10
AR 714
DI 10.1186/1471-2458-10-714
PG 11
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA 695EC
UT WOS:000285352400001
PM 21092104
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Eirin, A
   Lerman, LO
AF Eirin, Alfonso
   Lerman, Lilach O.
TI Stem cell-derived extracellular vesicles for renal repair: do
   cardiovascular comorbidities matter?
SO AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
LA English
DT Review
DE chronic kidney disease; extracellular vesicles; mesenchymal stem cells;
   metabolic syndrome; obesity
ID ENDOTHELIAL PROGENITOR CELLS; HUMAN ADIPOSE-TISSUE; MESENCHYMAL STEM;
   METABOLIC SYNDROME; DIABETIC-PATIENTS; OXIDATIVE STRESS; STROMAL CELLS;
   KIDNEY; DIFFERENTIATION; MICROVESICLES
AB Extracellular vesicle (EV)-based regenerative therapy has shown promising results in preclinical models of renal disease and might be useful for patients with several forms of chronic kidney disease. However, individuals with chronic kidney disease often present with comorbidities, including obesity, hypertension, diabetes, or even metabolic syndrome, which may alter the endogenous characteristics and impair the reparative capacity of stem cells and their daughter EVs. This brief review summarizes evidence of alterations in the morphology, cargo, and function of mesenchymal stem cells and mesenchymal stem cell-derived EVs in the face of cardiovascular disease. We further discuss the important ramifications for their use in patients with kidney disease.
C1 [Eirin, Alfonso; Lerman, Lilach O.] Mayo Clin, Div Nephrol & Hypertens, Dept Internal Med, Rochester, MN 55905 USA.
C3 Mayo Clinic
RP Eirin, A (corresponding author), Mayo Clin, Div Nephrol & Hypertens, 200 First St SW, Rochester, MN 55905 USA.
EM eirinmassat.alfonso@mayo.edu
RI Lerman, Lilach/M-4962-2017; Eirin, Alfonso/N-9873-2013
OI Eirin, Alfonso/0000-0002-3864-9644
FU National Institute of Diabetes and Digestive and Kidney Diseases
   [DK-106427, DK-122137, DK-104273, DK-120292, DK-102325]
FX This work was supported by National Institute of Diabetes and Digestive
   and Kidney Diseases Grants DK-106427, DK-122137, DK-104273, DK-120292,
   and DK-102325.
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NR 62
TC 6
Z9 6
U1 0
U2 7
PU AMER PHYSIOLOGICAL SOC
PI Rockville
PA 6120 Executive Blvd, Suite 600, Rockville, MD, UNITED STATES
SN 1931-857X
EI 1522-1466
J9 AM J PHYSIOL-RENAL
JI Am. J. Physiol.-Renal Physiol.
PD DEC
PY 2019
VL 317
IS 6
BP F1414
EP F1419
DI 10.1152/ajprenal.00434.2019
PG 6
WC Physiology; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology; Urology & Nephrology
GA JS8LX
UT WOS:000500554500003
PM 31630544
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Manchiryala, BR
   Tirupathi, UR
   Anand, T
AF Manchiryala, Bhagya Rekha
   Tirupathi, Usha Rani
   Anand, T.
TI Psoriasis and Its Association with Various Biochemical Parameters - A
   Clinico-Epidemiological Study
SO JOURNAL OF EVOLUTION OF MEDICAL AND DENTAL SCIENCES-JEMDS
LA English
DT Article
DE Metabolic Syndrome; Serum Uric Acid; Lipid Profile; Psoriatic Arthritis
ID DIABETES-MELLITUS; RISK; PREVALENCE
AB BACKGROUND
   Psoriasis is a chronic, genetically determined, inflammatory and proliferative disease of the skin and joints. It is associated with several co-morbidities including psoriatic arthritis, decreased quality of life, depression, increased cardiovascular risk, type 2 diabetes mellitus, hypertension, metabolic syndrome, cancer and Crohn's disease. Patients with metabolic syndrome are at a significantly increased risk of developing cardiovascular morbidity and mortality. Increased rates of depression in patients with psoriasis may be another factor leading to increased risk of cardiovascular disease.
   METHODS
   The study was conducted among 100 cases of psoriasis of either sex attending Dermatology, Venereology, Leprosy OPD at MGM Hospital, Warangal, during the period of January 2015 to June 2016.
   RESULTS
   A total of 100 cases of psoriasis and 100 age and sex matched controls were recruited. Detailed history, thorough physical & clinical examination and lab investigations were carried out. The severity of psoriasis was assessed using the PASI score. The results obtained have been depicted in tabular and graph format. Statistical analysis of the cases and controls was carried out.
   CONCLUSIONS
   The present study concluded that psoriatic patients were not at any increased risk of cardiovascular co-morbidities as we did not note any significant correlation between the derangements of lipid parameters and occurrence of co-existent diabetes or hypertension. Another important conclusion deducted from the present study was that there was no discrepancy in the parameters of lipid profile with the severity of psoriasis.
C1 [Manchiryala, Bhagya Rekha; Tirupathi, Usha Rani; Anand, T.] Kakatiya Med Coll, Dept DVL, Warangal, Telangana, India.
C3 Kakatiya Medical College
RP Manchiryala, BR (corresponding author), H 6-2-83, Warangal, Telangana, India.
EM dr.sbrekha@gmail.com
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NR 30
TC 0
Z9 0
U1 1
U2 3
PU JOURNAL EVOLUTION MEDICAL & DENTAL SCIENCES
PI KARNATAKA
PA C/O AKSHANTALA ENTERPRISES, NO 65, 1ST FL, SAHUKAR CHENNIAH RD, MYSORE,
   KARNATAKA, 570 009, INDIA
SN 2278-4748
EI 2278-4802
J9 J EVOL MED DENT SCI-
JI J. Evol. Med. Dent. Sci.-JEMDS
PD MAR 23
PY 2020
VL 9
IS 12
BP 900
EP 904
DI 10.14260/jemds/2020/194
PG 5
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA LK1QD
UT WOS:000530632500001
OA gold
DA 2025-06-11
ER

PT J
AU Tishova, Y
   Kalinchenko, SY
AF Tishova, Yuliya
   Kalinchenko, Svetlana Y.
TI Breaking the vicious circle of obesity: the metabolic syndrome and low
   testosterone by administration of testosterone to a young man with
   morbid obesity
SO ARQUIVOS BRASILEIROS DE ENDOCRINOLOGIA E METABOLOGIA
LA English
DT Article
DE Obesity; metabolic syndrome; testosterone; erectile function
ID ERECTILE DYSFUNCTION; ANDROGEN LEVELS; DARK SIDE; MEN; DEFICIENCY; DIET
AB Objective: The metabolic syndrome (MS) is associated with low serum testosterone levels. Conversely, low testosterone levels induce MS. These operational mechanisms reinforce one another and induce a vicious cycle. This is a report on a morbid obesity 42 year-old man with the MS and serum testosterone of 5.0 nmol/L (N: 12.0-33.0), who was resistant to treatment with diet and exercise. He was treated with testosterone undecanoate for 16 months. Methods: Anthropological and laboratory variables were measured before and during testosterone administration. Also the Aging Male Symptom Scale (AMS), the International Index of Erectile Function (IIEF) and Beck's Depression Inventory were assessed. Results: After 16 months, there was a weight loss of 50 kg and a decrease in waist circumference of 36.5 cm. Blood pressure normalized and laboratory variables returned to the normal range. The patient did not meet the criteria for the MS anymore. There were improvements on the AMS, the IIEF and Beck's Depression Inventory. Conclusions: Normalizing testosterone in men with morbid obesity in combination with diet and exercise, with the MS and low testosterone levels, may rescue them from the MS, improving their mood and their stamina to follow a diet and to exercise. Arq Bras Endocrinol Metab. 2009;53(8):1046-51
C1 [Tishova, Yuliya] Res Ctr Endocrinol, Dept Androl & Urol, Moscow 117136, Russia.
   [Kalinchenko, Svetlana Y.] Univ Russia, Chair Clin Androl, Moscow, Russia.
C3 Russian Academy of Medical Sciences; Endocrinology Research Centre
RP Tishova, Y (corresponding author), Res Ctr Endocrinol, Dept Androl & Urol, St D Ulyanova 11, Moscow 117136, Russia.
EM yulya_tishova@mail.rur
CR Alberti KGMM, 2005, LANCET, V366, P1059, DOI 10.1016/S0140-6736(05)67402-8
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   [No title captured]
NR 25
TC 2
Z9 2
U1 0
U2 5
PU SBEM-SOC BRASIL ENDOCRINOLOGIA & METABOLOGIA
PI RIO DE JANEIRO, RJ
PA RUA HUMAITA, 85 CJ 501, RIO DE JANEIRO, RJ, 22261-000, BRAZIL
SN 0004-2730
EI 1677-9487
J9 ARQ BRAS ENDOCRINOL
JI Arq. Bras. Endocrinol. Metabol.
PD NOV
PY 2009
VL 53
IS 8
BP 1047
EP 1051
DI 10.1590/S0004-27302009000800021
PG 5
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 535BG
UT WOS:000272941000021
PM 20126860
OA Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Menacho-Márquez, M
   Nogueiras, R
   Fabbiano, S
   Sauzeau, V
   Al-Massadi, O
   Diéguez, C
   Bustelo, XR
AF Menacho-Marquez, Mauricio
   Nogueiras, Ruben
   Fabbiano, Salvatore
   Sauzeau, Vincent
   Al-Massadi, Omar
   Dieguez, Carlos
   Bustelo, Xose R.
TI Chronic Sympathoexcitation through Loss of Vav3, a Rac1 Activator,
   Results in Divergent Effects on Metabolic Syndrome and Obesity Depending
   on Diet
SO CELL METABOLISM
LA English
DT Article
ID BROWN ADIPOSE-TISSUE; NERVOUS-SYSTEM; NEURONS; INSULIN; REGULATOR;
   FAMILY; ROLES
AB The role of the sympathetic nervous system, stress, and hypertension in metabolic syndrome and obesity remains unclear. To clarify this issue, we utilized genetically engineered mice showing chronic sympathoexcitation and hypertension due to lack of Vav3, a Rac1 activator. Here, we report that these animals develop metabolic syndrome under chow diet. However, they show protection from metabolic syndrome and obesity under fatty diets. These effects are elicited by alpha(1)-adrenergic- and diet-dependent metabolic changes in liver and the alpha(1)/beta(3) adrenergic-mediated stimulation of brown adipocyte thermogenesis. These responses seem to be engaged by the local action of noradrenaline in target tissues rather than by long-range effects of adrenaline. By contrast, they are not triggered by low parasympathetic drive or the hypertensive state present in Vav3-deficient mice. These results indicate that the sympathetic system plays divergent roles in the etiology of metabolic diseases depending on food regimen, sympathoexcitation source, and disease stage.
C1 [Menacho-Marquez, Mauricio; Fabbiano, Salvatore; Sauzeau, Vincent; Bustelo, Xose R.] Univ Salamanca, CSIC, Ctr Invest Canc, Salamanca 37007, Spain.
   [Menacho-Marquez, Mauricio; Fabbiano, Salvatore; Sauzeau, Vincent; Bustelo, Xose R.] Univ Salamanca, CSIC, Inst Biol Mol & Celular Canc, Salamanca 37007, Spain.
   [Nogueiras, Ruben; Al-Massadi, Omar; Dieguez, Carlos] Univ Santiago de Compostela, Dept Fisiol, Santiago De Compostela 15782, Spain.
   [Nogueiras, Ruben; Al-Massadi, Omar; Dieguez, Carlos] Univ Santiago de Compostela, Ctr Invest Med Mol & Enfermidades Cron, Santiago De Compostela 15782, Spain.
C3 Consejo Superior de Investigaciones Cientificas (CSIC); CSIC-USAL -
   Instituto de Biologia Molecular y Celular del Cancer de Salamanca
   (IBMCC); University of Salamanca; CSIC - Centro de Investigacion del
   Cancer (CIC); Consejo Superior de Investigaciones Cientificas (CSIC);
   CSIC-USAL - Instituto de Biologia Molecular y Celular del Cancer de
   Salamanca (IBMCC); University of Salamanca; Universidade de Santiago de
   Compostela; Universidade de Santiago de Compostela
RP Bustelo, XR (corresponding author), Univ Salamanca, CSIC, Ctr Invest Canc, Salamanca 37007, Spain.
EM xbustelo@usal.es
RI Nogueiras, Ruben/AAS-9427-2021; Sauzeau, Vincent/D-3548-2015; Bustelo,
   Xose R./A-9526-2010; Al-Massadi, Omar/C-1526-2017
OI Sauzeau, Vincent/0000-0002-6187-0312; dieguez,
   carlos/0000-0002-0919-4337; Fabbiano, Salvatore/0000-0003-0768-6028;
   Nogueiras, Ruben/0000-0002-9976-9930; Bustelo, Xose
   R./0000-0001-9398-6072; Al-Massadi, Omar/0000-0003-0645-6159
FU Spanish Ministry of Economy & Competitiveness [SAF2009-07172,
   SAF2012-31371, RD06/0020/0001, RD12/0036/0002, RYC-2008-02219,
   SAF2009-07049]; Spanish Ministry of Economy & Competitiveness (CIBER de
   Fisiopatologia de la Obesidad y Nutricion) [BFU2011]; Galician
   Autonomous Government; European Union [ERC-2011-StG-OBESITY53-281408,
   245009]; European Regional Development Fund
FX We thank J.M. Lopez-Novoa for comments on this work and A. Abad, M.
   Blazquez, and T. Teixeira for technical assistance. Work was supported
   by grants from the Spanish Ministry of Economy & Competitiveness to X.
   R. B. (SAF2009-07172, SAF2012-31371, RD06/0020/0001, RD12/0036/0002),
   R.N. (RYC-2008-02219, SAF2009-07049), and C. D. (BFU2011, CIBER de
   Fisiopatologia de la Obesidad y Nutricion); the Galician Autonomous
   Government to R.N. (2010/14); and the European Union 7th Framework
   Program to R.N. (ERC-2011-StG-OBESITY53-281408, 245009) and C. D.
   (245009). Spanish funding was cosponsored by the European Regional
   Development Fund. The authors declare no competing financial interests.
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NR 29
TC 23
Z9 23
U1 0
U2 15
PU CELL PRESS
PI CAMBRIDGE
PA 50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA
SN 1550-4131
EI 1932-7420
J9 CELL METAB
JI Cell Metab.
PD AUG 6
PY 2013
VL 18
IS 2
BP 199
EP 211
DI 10.1016/j.cmet.2013.07.001
PG 13
WC Cell Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Endocrinology & Metabolism
GA 242UF
UT WOS:000326267200008
PM 23931752
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Nisha, Y
   Bobby, Z
   Wadwekar, V
AF Nisha, Yadav
   Bobby, Zachariah
   Wadwekar, Vaibhav
TI Biochemical derangements related to metabolic syndrome in epileptic
   patients on treatment with valproic acid
SO SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
LA English
DT Article
DE Metabolic syndrome; Oxidative stress; Valproic acid
ID ANTIEPILEPTIC DRUGS; INSULIN-RESISTANCE; TRACE-ELEMENTS; SERUM-INSULIN;
   RISK-FACTORS; OBESITY; ADIPONECTIN; ANTIOXIDANT; LEPTIN
AB Purpose: Evaluation of biochemical derangements related to metabolic syndrome in epileptic patients on treatment with Valproic acid.
   Methods: This study consisted of two groups of 42 patients. Group I - Newly diagnosed patients with epileptic seizures untreated with any Anti-epileptic drugs (AEDs). Group II - Patients on treatment with Valproic acid for more than one year. Age and gender matched patients of 18-40 years were recruited. Patients who were diabetic, hypertensive, smokers, alcoholics, with persistent infection, head injuries, pregnancy and lactation were excluded from the study. Biochemical parameters, fasting blood glucose, lipid profile, Malondialdehyde (MDA), Total Antioxidant Status (TAS), MDA/TAS ratio, leptin, adiponectin, fasting insulin, high sensitive c-reactive protein (hsCRP), Homeostatic model assessment of insulin resistance (HOMA-IR) and leptin/adiponectin ratio were estimated.
   Results: There was a decrease in Total cholesterol and Low Density Lipoprotein- cholesterol levels among the VPA-treated epileptic patients in comparison to newly diagnosed patients. BMI did not differ between the untreated and treated patients. There were no significant difference in the levels of hsCRP, leptin and TAS between the newly diagnosed and VPA-treated patients. Increased insulin as well as HOMA-IR levels and decreased adiponectin levels were found in VPA treated subjects when compared to the newly diagnosed patients. Oxidative stress parameters (MDA, MDA/TAS ratio) were elevated in VPA treated subjects when compared to newly diagnosed patients.
   Conclusion: VPA treatment increased the risk factors for the development of metabolic syndrome such as hyperinsulinemia, insulin resistance and oxidative stress. However VPA treatment corrected the dyslipidemia of epileptic patients.
C1 [Nisha, Yadav; Bobby, Zachariah] JIPMER, Dept Biochem, Pondicherry 605006, India.
   [Wadwekar, Vaibhav] JIPMER, Dept Neurol, Pondicherry 605006, India.
C3 Jawaharlal Institute of Postgraduate Medical Education & Research;
   Jawaharlal Institute of Postgraduate Medical Education & Research
RP Bobby, Z (corresponding author), JIPMER, Dept Biochem, Pondicherry 605006, India.
EM bobby.zac@jipmer.edu.in
RI Zachariah, Bobby/IUQ-0806-2023; Wadwekar, Vaibhav/AAD-4191-2021
FU JIPMER, Puducherry, India
FX This study was carried with the intramural funds received from JIPMER,
   Puducherry-6, India.
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NR 28
TC 22
Z9 24
U1 0
U2 5
PU W B SAUNDERS CO LTD
PI LONDON
PA 32 JAMESTOWN RD, LONDON NW1 7BY, ENGLAND
SN 1059-1311
EI 1532-2688
J9 SEIZURE-EUR J EPILEP
JI Seizure
PD AUG
PY 2018
VL 60
BP 57
EP 60
DI 10.1016/j.seizure.2018.06.003
PG 4
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA GU5BR
UT WOS:000445300300008
PM 29906708
OA Bronze
DA 2025-06-11
ER

PT J
AU Pravenec, M
   Kozich, V
   Krijt, J
   Sokolová, J
   Zídek, V
   Landa, V
   Simáková, M
   Mlejnek, P
   Silhavy, J
   Oliyarnyk, O
   Kazdová, L
   Kurtz, TW
AF Pravenec, Michal
   Kozich, Viktor
   Krijt, Jakub
   Sokolova, Jitka
   Zidek, Vaclav
   Landa, Vladimir
   Simakova, Miroslava
   Mlejnek, Petr
   Silhavy, Jan
   Oliyarnyk, Olena
   Kazdova, Ludmila
   Kurtz, Theodore W.
TI Folate Deficiency Is Associated With Oxidative Stress, Increased Blood
   Pressure, and Insulin Resistance in Spontaneously Hypertensive Rats
SO AMERICAN JOURNAL OF HYPERTENSION
LA English
DT Article
DE blood pressure; ectopic fat accumulation; folate deficiency;
   homocysteine; hypertension; oxidative stress; spontaneously hypertensive
   rat
ID FOLIC-ACID SUPPLEMENTATION; METABOLIC SYNDROME; HOMOCYSTEINE
   CONCENTRATIONS; PLASMA; HYPERHOMOCYSTEINAEMIA; FORTIFICATION;
   ADOLESCENTS; STEATOSIS; MODEL
AB BACKGROUND
   The role of folate deficiency and associated hyperhomocysteinemia in the pathogenesis of metabolic syndrome is not fully established. In the current study, we analyzed the role of folate deficiency in pathogenesis of the metabolic syndrome in the spontaneously hypertensive rat (SHR).
   METHODS
   Metabolic and hemodynamic traits were assessed in SHR/Ola rats fed either folate-deficient or control diet for 4 weeks starting at the age of 3 months.
   RESULTS
   Compared to SHRs fed a folate-replete diet, SHRs fed a folate-deficient diet showed significantly reduced serum folate (104 +/- 5 vs. 11 +/- 1 nmol/L, P < 0.0005) and urinary folate excretion (4.3 +/- 0.6 vs. 1.2 +/- 0.1 nmol/16 h, P < 0.0005) together with a near 3-fold increase in plasma total homocysteine concentration (4.5 +/- 0.1 vs 13.1 +/- 0.7 mu mol/L, P < 0.0005), ectopic fat accumulation in liver, and impaired glucose tolerance. Folate deficiency also increased systolic blood pressure by approximately 15 mm Hg (P < 0.01). In addition, the low-folate diet was accompanied by significantly reduced activity of antioxidant enzymes and increased concentrations of lipoperoxidation products in liver, renal cortex, and heart.
   CONCLUSIONS
   These findings demonstrate that the SHR model is susceptible to the adverse metabolic and hemodynamic effects of low dietary intake of folate. The results are consistent with the hypothesis that folate deficiency can promote oxidative stress and multiple features of the metabolic syndrome that are associated with increased risk for diabetes and cardiovascular disease.
C1 [Pravenec, Michal; Zidek, Vaclav; Landa, Vladimir; Simakova, Miroslava; Mlejnek, Petr; Silhavy, Jan] Acad Sci Czech Republic, Inst Physiol, Prague, Czech Republic.
   [Kozich, Viktor; Krijt, Jakub; Sokolova, Jitka] Charles Univ Prague, Fac Med 1, Inst Inherited Metab Disorders, Prague, Czech Republic.
   [Kozich, Viktor; Krijt, Jakub; Sokolova, Jitka] Gen Univ Hosp, Prague, Czech Republic.
   [Oliyarnyk, Olena; Kazdova, Ludmila] Inst Clin & Expt Med, Prague, Czech Republic.
   [Kurtz, Theodore W.] Univ Calif San Francisco, San Francisco, CA 94143 USA.
C3 Czech Academy of Sciences; Institute of Physiology of the Czech Academy
   of Sciences; Charles University Prague; General University Hospital
   Prague; Institute for Clinical & Experimental Medicine (IKEM);
   University of California System; University of California San Francisco
RP Pravenec, M (corresponding author), Acad Sci Czech Republic, Inst Physiol, Prague, Czech Republic.
EM pravenec@biomed.cas.cz
RI Zidek, Vaclav/C-6685-2012; Simakova, Miroslava/R-5367-2019; Oliyarnyk,
   Olena/Q-6380-2019; Silhavy, Jan/B-5292-2014; Landa,
   Vladimir/B-8908-2012; Sokolova, Jitka/H-9924-2015; Kozich,
   Viktor/A-7672-2008; Krijt, Jakub/F-4861-2017; Mlejnek, Petr/C-2305-2012;
   Pravenec, Michal/B-1666-2012
OI Simakova, Miroslava/0000-0003-1468-5832; Sokolova,
   Jitka/0000-0002-0453-3336; Kozich, Viktor/0000-0001-5820-5277;
   Oliyarnyk, Olena/0000-0002-4912-6187; Krijt, Jakub/0000-0002-1738-654X;
   Mlejnek, Petr/0000-0002-4218-8983; Pravenec, Michal/0000-0001-9197-5871
FU Ministry of Health of the Czech Republic [NS10036-4/2008, MZO00023001];
   Charles University [PRVOUK P24, UNCE 204011]; Ministry of Education of
   the Czech Republic [ME10019, 7E10067]; Grant Agency of the Czech
   Republic [P303/10/0505]; European Commission [HEALTH-F4-2010-241504];
   National Institutes of Health [HL35018, HL56028, HL63709]; 
   [RVO:67985823]
FX We acknowledge the support by grants NS10036-4/2008 and MZO00023001
   (Ministry of Health of the Czech Republic) and institutional support
   provided by the Research Projects RVO:67985823 and by Charles
   University-First Faculty of Medicine programs PRVOUK P24 and UNCE
   204011. This work was also supported by grants ME10019 and 7E10067 from
   the Ministry of Education of the Czech Republic, P303/10/0505 from the
   Grant Agency of the Czech Republic, and by the European Commission
   within the Seventh Framework Programme through the Integrated Project
   EURATRANS (contract no. HEALTH-F4-2010-241504). We also acknowledge
   support from National Institutes of Health grants HL35018, HL56028, and
   HL63709 to T.W.K. We also thank Ms. A. Duta, Ms. A. Musilova, and Ms. K.
   Pelinkova, MSc, for technical help.
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NR 38
TC 76
Z9 85
U1 0
U2 37
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0895-7061
J9 AM J HYPERTENS
JI Am. J. Hypertens.
PD JAN
PY 2013
VL 26
IS 1
BP 135
EP 140
DI 10.1093/ajh/hps015
PG 6
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 076QO
UT WOS:000313972600019
PM 23382337
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Chen, SH
   Chen, SC
   Lai, YP
   Chen, PH
   Yeh, KY
AF Chen, Sue-Hsien
   Chen, Shu-Ching
   Lai, Yo-Ping
   Chen, Pin-Hsuan
   Yeh, Kun-Yun
TI Abdominal obesity and hypertension are correlated with health-related
   quality of life in Taiwanese adults with metabolic syndrome
SO BMJ OPEN DIABETES RESEARCH & CARE
LA English
DT Article
DE metabolic syndrome; obesity; quality of life
ID NUTRITION EXAMINATION SURVEY; NATIONAL-HEALTH; INDIVIDUALS; MORTALITY;
   IMPACT; WOMEN
AB Objective Metabolic syndrome (MetS) gains more attention due to high prevalence of obesity, diabetes and hypertension among adults. Although obesity, diabetes and hypertension can certainly compromise health-related quality of life (HRQoL), the correlations of sociodemographic factors, quality of life and MetS remains unclear. This study aims to investigate the association between HRQoL and MetS in an Asian community of the sociodemographic characteristics.
   Research design and methods We performed a cross-sectional study by recruiting 2588 Taiwanese patients aged >= 30 years between August 2015 and August 2017. Sociodemographic data and anthropometric variables were obtained from medical records and physical examination. Meanwhile, HRQoL was assessed by 36-Item Short-Form Health Survey questionnaires.
   Results The overall prevalence of MetS was 32.8%. Multivariate analysis revealed that age >= 65 years (OR=1.987, p<0.001), body mass index (BMI) >= 24 kg/m(2) (OR=7.958, p<0.001), low educational level (OR=1.429, p=0.014), bad self-perceived health status (OR=1.315, p=0.01), and betel nut usage (OR=1.457, p=0.048) were associated with the development of MetS. For patients with MetS, the physical and mental health domains of HRQoL are negatively correlated with abdominal obesity and hypertension, respectively.
   Conclusions Adult MetS in Taiwan was associated with certain sociodemographic factors including older age, high BMI, low educational level, bad self-perceived health status, and betel nut use. Abdominal obesity and hypertension was correlated with HRQoL in patients with MetS.
C1 [Chen, Sue-Hsien; Chen, Pin-Hsuan] Chang Gung Mem Hosp, Community Med Res Ctr, Keelung, Taiwan.
   [Chen, Sue-Hsien] Chang Gung Univ Sci & Technol, Sch Nursing, Taoyuan, Taiwan.
   [Chen, Shu-Ching] Natl Taiwan Univ Hosp, Dept Med Res, Taipei, Taiwan.
   [Lai, Yo-Ping] Natl Taiwan Univ Hosp, Dept Internal Med, Taipei, Taiwan.
   [Yeh, Kun-Yun] Keelung & Chang Gung Univ, Chang Gung Mem Hosp, Div Hematooncol, Coll Med,Dept Internal Med, Keelung, Taiwan.
C3 Chang Gung Memorial Hospital; Chang Gung University of Science &
   Technology; National Taiwan University; National Taiwan University
   Hospital; National Taiwan University; National Taiwan University
   Hospital; Chang Gung Memorial Hospital
RP Yeh, KY (corresponding author), Keelung & Chang Gung Univ, Chang Gung Mem Hosp, Div Hematooncol, Coll Med,Dept Internal Med, Keelung, Taiwan.
EM yehtyng@gmail.com
OI Chen, Shu-Ching/0000-0001-9112-1526; Chen, Sue-hsien/0000-0002-6995-860X
FU Chung Gang Memorial Hospital, Keelung [CRRPG2B0191similar to2B0194]
FX This study was supported by grants (CRRPG2B0191 similar to 2B0194) from
   the Chung Gang Memorial Hospital, Keelung.
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NR 37
TC 10
Z9 10
U1 0
U2 0
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
EI 2052-4897
J9 BMJ OPEN DIAB RES CA
JI BMJ Open Diab. Res. Care
PD JAN
PY 2020
VL 8
IS 1
AR e000947
DI 10.1136/bmjdrc-2019-000947
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism
GA NU8UG
UT WOS:000573912300021
PM 32079613
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Zhang, YY
   Chen, J
   Zhang, K
   Kong, MY
   Wang, T
   Chen, RH
   Wang, LL
   Wang, JF
   Huang, H
AF Zhang, Yinyin
   Chen, Jie
   Zhang, Kun
   Kong, Minyi
   Wang, Tao
   Chen, Renhua
   Wang, Lily
   Wang, Jingfeng
   Huang, Hui
TI Inflammation and Oxidative Stress are Associated with the Prevalence of
   High Aankle-brachial Index in Metabolic Syndrome Patients without
   Chronic Renal Failure
SO INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
LA English
DT Article
DE High ankle-brachial index; metabolic syndrome; inflammation; oxidative
   stress; metabolic risk factors
ID INCIDENT CARDIOVASCULAR EVENTS; BLOOD-PRESSURE INDEX; C-REACTIVE
   PROTEIN; VASCULAR CALCIFICATION; INSULIN-RESISTANCE; ALL-CAUSE;
   MORTALITY; DISEASE; RISK
AB Aims: High ankle-brachial index (ABI) is marker of increased cardiovascular morbidity and mortality, while the relationship and mechanism between high ABI and metabolic syndrome (MetS) are unclear. The objectives of this study were to determine the relationship and possible mechanism of MetS with high ABI.
   Methods: 341 participants without CRF were recruited. Among these participants, 58 participants (ABI >= 1.3) were include in high ABI group and the other 283 participants (0.9 < ABI < 1.3) were include in normal ABI group. Furthermore, these 341 participants were also divided into MetS group (n = 54) and non-MetS group (n = 287). All participants received examinations including body mass index (BMI), ABI and related biochemical parameters.
   Results: Compared with non-MetS group, the prevalence of high ABI was higher in MetS group (27.8% vs. 15%, p < 0.05). Participants with 3-4 metabolic risk factors had higher prevalence of high ABI than those with 0-1 metabolic risk factors (27.8% vs. 12.7%, p < 0.05). The prevalence of high ABI in overweight participants was higher than those with normal body weight. And the participants with hypertension also had higher prevalence of high ABI than normotensive participants. BMI, high-sensitivity C-reactive protein (hsCRP) and superoxide dismutase (SOD) were all higher in high ABI group than normal ABI group (p < 0.05).
   Conclusions: More metabolic risk factors have increased the risk of high ABI. Inflammation and oxidative stress are associated with prevalence of high ABI in metabolic syndrome patients without chronic renal failure.
C1 [Zhang, Yinyin; Zhang, Kun; Kong, Minyi; Chen, Renhua; Wang, Jingfeng; Huang, Hui] Sun Yat Sen Univ, Dept Cardiol, Sun Yat sen Mem Hosp, Guangzhou 510120, Guangdong, Peoples R China.
   [Zhang, Yinyin; Chen, Jie; Zhang, Kun; Wang, Tao; Chen, Renhua; Wang, Lily; Wang, Jingfeng; Huang, Hui] Guangdong Prov Key Lab Arrhythmia & Elect, Guangzhou 510120, Guangdong, Peoples R China.
   [Chen, Jie] Sun Yat Sen Univ, Dept Radiat Oncol, Sun Yat sen Mem Hosp, Guangzhou 510120, Guangdong, Peoples R China.
C3 Sun Yat Sen University; Sun Yat Sen University
RP Huang, H (corresponding author), Sun Yat Sen Univ, Dept Cardiol, Sun Yat sen Mem Hosp, 107 W Yanjiang Rd, Guangzhou 510120, Guangdong, Peoples R China.
EM drwjfsums@gmail.com; huangh8@mail.sysu.edu.cn
FU National Natural Science Foundation of China [81170647, 91029742,
   30973207, 30971262]
FX This work was supported in part by National Natural Science Foundation
   of China [81170647, 91029742 and 30973207 to Hui Huang, 30971262 to
   Jingfeng Wang].
CR Aboyans V, 2011, ATHEROSCLEROSIS, V214, P169, DOI 10.1016/j.atherosclerosis.2010.10.011
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NR 37
TC 12
Z9 15
U1 0
U2 8
PU IVYSPRING INT PUBL
PI LAKE HAVEN
PA PO BOX 4546, LAKE HAVEN, NSW 2263, AUSTRALIA
SN 1449-1907
J9 INT J MED SCI
JI Int. J. Med. Sci.
PY 2013
VL 10
IS 2
BP 183
EP 190
DI 10.7150/ijms.5308
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 070SV
UT WOS:000313532200011
PM 23329891
OA Green Submitted, Green Published, gold, Green Accepted
DA 2025-06-11
ER

PT J
AU McIntyre, RS
   Woldeyohannes, HO
   Soczynska, JK
   Miranda, A
   Lachowski, A
   Liauw, SS
   Grossman, T
   Lourenco, MT
   Kim, B
   Alsuwaidan, MT
   Kennedy, SH
AF McIntyre, Roger S.
   Woldeyohannes, Hanna O.
   Soczynska, Joanna K.
   Miranda, Andrew
   Lachowski, Angela
   Liauw, Samantha S.
   Grossman, Talia
   Lourenco, Maria T.
   Kim, Byungsu
   Alsuwaidan, Mohammad T.
   Kennedy, Sidney H.
TI The Rate of Metabolic Syndrome in Euthymic Canadian Individuals with
   Bipolar I/II Disorder
SO ADVANCES IN THERAPY
LA English
DT Article
DE asymptomatic; bipolar disorder; metabolic syndrome
ID MEDICAL COMORBIDITY; PREVALENCE; HEALTH; DEPRESSION
AB Objective: To report on the rate of metabolic syndrome, as defined by the National Cholesterol Education Program (NCEP) Adult Treatment Panel III (ATP III), in asymptomatic adults with bipolar I/II disorder evaluated at the Mood Disorders Psychopharmacology Unit (MDPU), University Health Network, University of Toronto. To our knowledge, this is the first study reporting on the rate of metabolic syndrome in a Canadian clinical sample and exclusively evaluating asymptomatic individuals. Methods: This was a post-hoc, cross-sectional analysis of adult bipolar subjects who were primarily enrolled in a clinical intervention study. All subjects in this sample were asymptomatic at the time of assessing metabolic parameters. Results: Data from 99 euthymic bipolar subjects (n=51 female, n=48 male) were included for the analysis. The sample mean age +/- SD was 38 +/- 11.15 years. Thirty-one subjects (32.6%) met criteria for the metabolic syndrome with no significant differences as a function of sex. The waist circumference criterion was met in 37 (41.1%) subjects. Diastolic and systolic blood pressure criteria were met in 26 (27.6%) and 28 (29.7%) subjects, respectively. Thirty-one subjects (36.4%) met the high-density lipoprotein (HDL) criterion, while 33 (38.8%) met the triglyceride criterion. Moreover, five (6.1%) met the criterion for high fasting glucose level (diabetes mellitus or glucose/insulin dysregulation at screening was an exclusion criterion). Men were more likely to have high diastolic (P=0.001) and systolic blood pressure (P=0.007) as well as hypertriglyceridemia (P=0.037). Abdominal obesity, HDL, and fasting glucose levels were not significantly different between men and women. Bipolar individuals with concurrent metabolic syndrome had a later age at first treatment and increased number of total hospitalizations. Conclusion: Asymptomatic Canadian individuals with bipolar disorder exhibit a high rate of concurrent metabolic syndrome. The results herein buttress recommendations for risk factor screening and modification, ongoing surveillance, as well as primary and secondary prevention strategies for metabolic abnormalities in individuals with bipolar disorder.
C1 [McIntyre, Roger S.; Alsuwaidan, Mohammad T.; Kennedy, Sidney H.] Univ Toronto, Dept Psychiat, Toronto, ON, Canada.
   [McIntyre, Roger S.] Univ Toronto, Dept Pharmacol, Toronto, ON, Canada.
   [McIntyre, Roger S.; Woldeyohannes, Hanna O.; Soczynska, Joanna K.; Miranda, Andrew; Lachowski, Angela; Liauw, Samantha S.; Grossman, Talia; Lourenco, Maria T.; Alsuwaidan, Mohammad T.; Kennedy, Sidney H.] Univ Hlth Network, Mood Disorders Psychopharmacol Unit, Toronto, ON, Canada.
   [Kim, Byungsu] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Psychiat, Seoul, South Korea.
   [Kim, Byungsu] Univ Ulsan, Coll Med, Asan Med Ctr, Hlth Promot Ctr, Seoul, South Korea.
   [McIntyre, Roger S.; Soczynska, Joanna K.; Kennedy, Sidney H.] Univ Toronto, Inst Med Sci, Toronto, ON M5S 1A1, Canada.
C3 University of Toronto; University of Toronto; University of Toronto;
   University Health Network Toronto; University of Ulsan; Asan Medical
   Center; University of Ulsan; Asan Medical Center; University of Toronto
RP McIntyre, RS (corresponding author), Univ Toronto, Dept Psychiat, Toronto, ON, Canada.
EM Roger.McIntyre@uhn.on.ca
RI Kennedy, Sidney/AGR-7227-2022; Kim, Byungsu/JNE-3151-2023; Lourenco,
   Maria/C-3525-2017; McIntyre, Roger/AAU-1000-2020; kennedy,
   sidney/Q-1926-2016
OI Alsuwaidan, Mohammad/0000-0003-1344-2935; Soczynska,
   Joanna/0000-0003-0003-7164; kennedy, sidney/0000-0001-5339-7185
FU Stanley Medical Research Institute; Eli Lilly; Janssen-Ortho; Shire;
   AstraZeneca; Pfizer
FX This study was supported by the Stanley Medical Research Institute. Dr.
   Roger S. McIntyre is on the advisory board for AstraZeneca,
   Bristol-Myers Squibb, France Foundation, GlaxoSmithKline, Janssen-Ortho,
   Solvay/Wyeth, Eli Lilly, Organon, Lundbeck, Biovail, Pfizer, Shire,
   Schering-Plough, and Merck. He is also on the speaker's bureau for
   Janssen-Ortho, AstraZeneca, Eli Lilly, Lundbeck, Biovail, and Merck, and
   has received research grants from Eli Lilly, Janssen-Ortho, Shire,
   AstraZeneca, and Pfizer.
CR American Psychiatric Association, 2000, spectrum disorders using the current DSM-IV-TR diagnostic, V4th, DOI 10.1176/dsm10.1176/appi.books.9780890420249.dsm-iv-tr
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   *CAN HLTH MEAS SUR, DIAB AG GROUP SEX
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NR 23
TC 31
Z9 36
U1 0
U2 3
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0741-238X
EI 1865-8652
J9 ADV THER
JI Adv. Ther.
PD NOV
PY 2010
VL 27
IS 11
BP 828
EP 836
DI 10.1007/s12325-010-0072-z
PG 9
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA 690SJ
UT WOS:000285026800006
PM 20878373
DA 2025-06-11
ER

PT J
AU Suzuki, Y
   Ichihara, G
   Sahabudeen, SM
   Kato, A
   Yamaguchi, T
   Imanaka-Yoshida, K
   Yoshida, T
   Yamada, Y
   Ichihara, S
AF Suzuki, Yuka
   Ichihara, Gaku
   Sahabudeen, Sheik Mohideen
   Kato, Ai
   Yamaguchi, Takanori
   Imanaka-Yoshida, Kyoko
   Yoshida, Toshimichi
   Yamada, Yoshiji
   Ichihara, Sahoko
TI Rats with metabolic syndrome resist the protective effects of N-acetyl
   L-cystein against impaired spermatogenesis induced by
   high-phosphorus/zinc-free diet
SO EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY
LA English
DT Article
DE Metabolic syndrome; Testicular dysfunction; Oxidative stress; Apoptosis
ID INDUCED TESTICULAR APOPTOSIS; HYPERTENSIVE KOLETSKY RAT; BODY-MASS
   INDEX; OXIDATIVE STRESS; ZINC-DEFICIENCY; MALE OBESITY; ACETYLCYSTEINE;
   ANTIOXIDANT; ACTIVATION; EXPRESSION
AB Consumption of relatively high amounts of processed food can result in abnormal nutritional status, such as zinc deficiency or phosphorus excess. Moreover, hyperphosphatemia and hypozincemia are found in some patients with diabetic nephropathy and metabolic syndrome. The present study investigated the effects of high-phosphorus/zinc-free diet on the reproductive function of spontaneously hypertensive rats/NDmcr-cp (SHR/cp), a model of the metabolic syndrome. We also investigated the effects of antioxidant, N-acetyl-L-cysteine (NAC), on testicular dysfunction under such conditions. Male SHR/cp and control rats (Wistar Kyoto rats, WKY) were divided into three groups; rats fed control diet (P 0.3%, w/w; Zn 0.2%, w/w), high-phosphorus and zinc-deficient diet (P 1.2%, w/w; Zn 0.0%, w/w) with vehicle, or high-phosphorus and zinc-deficient diet with NAC (1.5 mg/g/day) for 12 weeks (n = 6 or 8 rats/group). The weights of testis and epididymis were significantly reduced by high-phosphate/zinc-free diet in both SHR/cp and WKY. The same diet significantly reduced caudal epididymal sperm count and motility and induced histopathological changes in the testis in both strains. Treatment with NAC provided significant protection against the toxic effects of the diet on testicular function in WKY, but not in SHR/cp. The lack of the protective effects of NAC on impaired spermatogenesis in SHR/cp could be due to the more pronounced state of oxidative stress observed in these rats compared with WKY. (C) 2013 Elsevier GmbH. All rights reserved.
C1 [Suzuki, Yuka; Kato, Ai; Yamaguchi, Takanori; Yamada, Yoshiji; Ichihara, Sahoko] Mie Univ, Life Sci Res Ctr, Dept Human Funct Genom, Tsu, Mie 5148507, Japan.
   [Ichihara, Gaku; Sahabudeen, Sheik Mohideen] Nagoya Univ, Grad Sch Med, Dept Environm & Occupat Hlth, Nagoya, Aichi 4648601, Japan.
   [Imanaka-Yoshida, Kyoko; Yoshida, Toshimichi] Mie Univ, Grad Sch Med, Dept Pathol & Matrix Biol, Tsu, Mie 5148507, Japan.
   [Ichihara, Sahoko] Mie Univ, Grad Sch Reg Innovat Studies, Tsu, Mie 5148507, Japan.
C3 Mie University; Nagoya University; Mie University; Mie University
RP Ichihara, S (corresponding author), Mie Univ, Grad Sch Reg Innovat Studies, 1577 Kurimamachiya Cho, Tsu, Mie 5148507, Japan.
EM saho@gene.mie-u.ac.jp
RI ; Yoshida, Toshimichi/H-6204-2013
OI Ichihara, Gaku/0000-0001-5707-5300; Yoshida,
   Toshimichi/0000-0001-8935-8217
FU Japan Society for the Promotion of Science [22390122, LS056];
   Grants-in-Aid for Scientific Research [22390122] Funding Source: KAKEN
FX The authors thank Kumi Nakao for the secretarial support. This study was
   supported in part by grants from the Japan Society for the Promotion of
   Science (#22390122 and LS056).
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NR 53
TC 7
Z9 7
U1 1
U2 9
PU ELSEVIER GMBH, URBAN & FISCHER VERLAG
PI JENA
PA OFFICE JENA, P O BOX 100537, 07705 JENA, GERMANY
SN 0940-2993
EI 1618-1433
J9 EXP TOXICOL PATHOL
JI Exp. Toxicol. Pathol.
PD NOV
PY 2013
VL 65
IS 7-8
BP 1173
EP 1182
DI 10.1016/j.etp.2013.05.009
PG 10
WC Pathology; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pathology; Toxicology
GA 261TA
UT WOS:000327686300027
PM 23810784
DA 2025-06-11
ER

PT J
AU Suliman, S
   van den Heuvel, L
   Bröcker, E
   Seedat, S
AF Suliman, Sharain
   van den Heuvel, Leigh
   Brocker, Erine
   Seedat, Soraya
TI Neurocognitive difficulties in trauma-exposed adults with metabolic
   syndrome: no influence of PTSD status or PTSD and metabolic syndrome
   comorbidity
SO DISCOVER MENTAL HEALTH
LA English
DT Article
DE Adults .Metabolic Syndrome; Neurocognition; Posttraumatic Stress
   Disorder; Trauma-exposed
ID POSTTRAUMATIC-STRESS-DISORDER; MILD COGNITIVE IMPAIRMENT; PSYCHOLOGICAL
   DISORDERS; RISK-FACTORS; VALIDATION; DEMENTIA; PEOPLE; INFLAMMATION;
   PERFORMANCE; IMPACT
AB Background Metabolic syndrome (MetS) and posttraumatic stress disorder (PTSD) often co-occur and both may compromise cognition, owing in part to common underlying mechanisms. Few studies have investigated the additive effects of these disorders on cognitive performance. Our aims were to compare cognitive performance between patients with PTSD and trauma-exposed controls (TEC) and investigate the additive effects of MetS factors on cognition. Methods In this case-control study, we included 474 adult participants, 236 with PTSD and 238 TEC. Demographic, neuropsychiatric, metabolic-related, and neurocognitive assessments were undertaken and MANCOVAs performed controlling for age. Cognitive domains (immediate and delayed memory, attention, language, visuospatial performance, working memory and global cognition) were the dependent variables in the analysis. Patient status and presence/absence of MetS or MetS components were independent variables, in each model. Results Patients with PTSD did not demonstrate worse cognitive performance than TEC on the neurocognitive domains assessed, and the presence of MetS in patients with PTSD did not alter this finding. Individuals with MetS also did not demonstrate worse cognition when compared to those without MetS. When we looked at individual MetS features, higher BMI was associated with poorer visuospatial performance, Conclusions These findings contrast with many previous studies showing worse neurocognitive performance related to both PTSD and MetS. Further investigation is required to establish the contribution of MetS to cognitive deficits in those with PTSD. Generalisability and inferences regarding the directionality of associations are limited.
C1 [Suliman, Sharain; van den Heuvel, Leigh; Brocker, Erine; Seedat, Soraya] Stellenbosch Univ, Fac Med & Hlth Sci, Dept Psychiat, ZA-7550 Cape Town, South Africa.
   [Suliman, Sharain; van den Heuvel, Leigh; Brocker, Erine; Seedat, Soraya] Stellenbosch Univ, Fac Med & Hlth Sci, South African Med Res Council Genom Brain Disorder, Dept Psychiat, ZA-7550 Cape Town, South Africa.
C3 Stellenbosch University; Stellenbosch University
RP Suliman, S (corresponding author), Stellenbosch Univ, Fac Med & Hlth Sci, Dept Psychiat, ZA-7550 Cape Town, South Africa.; Suliman, S (corresponding author), Stellenbosch Univ, Fac Med & Hlth Sci, South African Med Res Council Genom Brain Disorder, Dept Psychiat, ZA-7550 Cape Town, South Africa.
EM sharain@sun.ac.za; llvdh@sun.ac.za; erineb@sun.ac.za; sseedat@sun.ac.za
RI van den Heuvel, Leigh/AGV-5481-2022; Suliman, Sharain/ABC-8843-2020
OI van den Heuvel, Leigh/0000-0003-3884-4754; Seedat,
   Soraya/0000-0002-5118-786X; Suliman, Sharain/0000-0001-5510-3128;
   Brocker, Erine/0000-0002-9861-9527
FU South African Medical Research Council (SAMRC) for the "Shared Roots"
   Flagship Project from the South African National Treasury under its
   Economic Competitiveness and Support Package
   [MRC-RFA-IFSP-01-2013/SHARED ROOTS]; South African Research Chairs
   Initiative in PTSD - Department of Science and Technology; South African
   National Research Foundation (NRF); SAMRC through a Self-Initiated
   Research Grant; NRF through the Competitive Programme for Rated
   Researchers [SRUG2204123207]; NRF [138430]; SAMRC under a Self-Initiated
   Research Grant; SAMRC through the Extramural Genomics of Brain Disorders
   Unit and through its Division of Research Capacity Development under the
   SAMRC Bongani Mayosi national health scholars programme of the South
   African Nation Treasury; National Research Foundation
FX Funding Research reported in this publication was supported by the South
   African Medical Research Council (SAMRC) for the "Shared Roots" Flagship
   Project, Grant no. MRC-RFA-IFSP-01-2013/SHARED ROOTS" through funding
   received from the South African National Treasury under its Economic
   Competitiveness and Support Package. SSu received post-doctoral support
   from the South African Research Chairs Initiative in PTSD funded by the
   Department of Science and Technology and the South African National
   Research Foundation (NRF), funding from the SAMRC through a
   Self-Initiated Research Grant, and funding from the NRF through the
   Competitive Programme for Rated Researchers (Grant Number
   SRUG2204123207). LvdH was supported in part by the NRF (Grant Number
   138430) and by the SAMRC under a Self-Initiated Research Grant. EB was
   supported by the SAMRC through the Extramural Genomics of Brain
   Disorders Unit and through its Division of Research Capacity Development
   under the SAMRC Bongani Mayosi national health scholars programme of the
   South African Nation Treasury. SSe was supported by the South African
   Research Chairs Initiative in PTSD funded by the Department of Science
   and Technology and the National Research Foundation. Funders have played
   no role in the study design, data collection, analysis, and
   interpretation and in writing the manuscript. Its' contents are solely
   the responsibility of the authors and do not necessarily represent the
   official views of the South African MRC or NRF.
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NR 70
TC 0
Z9 0
U1 0
U2 0
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
EI 2731-4383
J9 DISCOV MENT HEALTH
JI Discov. Ment. Heatlh
PD FEB 20
PY 2025
VL 5
IS 1
AR 16
DI 10.1007/s44192-025-00141-5
PG 12
WC Psychiatry
WE Emerging Sources Citation Index (ESCI)
SC Psychiatry
GA X8S2G
UT WOS:001427968800001
PM 39976743
OA gold
DA 2025-06-11
ER

PT J
AU Shiozaki, M
   Miyai, N
   Morioka, I
   Utsumi, M
   Hattori, S
   Koike, H
   Arita, M
   Miyashita, K
AF Shiozaki, Maki
   Miyai, Nobuyuki
   Morioka, Ikuharu
   Utsumi, Miyoko
   Hattori, Sonomi
   Koike, Hiroaki
   Arita, Mikio
   Miyashita, Kazuhisa
TI Job stress and behavioral characteristics in relation to coronary heart
   disease risk among Japanese police officers
SO INDUSTRIAL HEALTH
LA English
DT Article
DE Police officers; Coronary heart diseases; Behavioral characteristics;
   Job stress; Working condition
ID METABOLIC SYNDROME; SHIFT-WORK; CARDIOVASCULAR-DISEASE; MENTAL-HEALTH;
   PSYCHOSOCIAL FACTORS; PRONE BEHAVIOR; MORTALITY; ASSOCIATION;
   PREVALENCE; SYMPTOMS
AB This study examined the association between job-related behavioral characteristics and the risk of coronary heart diseases (CHD) in Japanese male police officers. Compared to office clerks, police officers exhibited greater age-related increases of the prevalence of CHD risk factors, and a clustering number of CHD risk factors was significantly higher in the group of those over 45 yr of age. Among the police officers, coronary-prone behavior was more frequent than that seen in office clerks. The police officers with coronary-prone behavior tended to engage in shift work and to work overtime more; yet they were less likely to perceive job stress and to express the relevant physical and psychological symptoms than those without coronary-prone behavior. The subjects with such behavioral characteristics had a significantly greater number of CHD risk factors. In a multiple regression analysis, coronary-prone behavior together with age, social support, walking hours per day, and amount of alcohol consumption were selected as significant determinants of a cluster of CHD risk factors. These results suggest that coronary-prone behavior may contribute to the higher prevalence of CHD risk factors in police officers via leading the long working hours and the work related unfavorable lifestyles, such as alcohol drinking and physical inactivity.
C1 [Shiozaki, Maki; Miyashita, Kazuhisa] Wakayama Med Univ, Sch Med, Dept Hyg, Wakayama, Japan.
   [Shiozaki, Maki; Koike, Hiroaki] Wakayama Prefectural Police, Welf Div, Wakayama, Japan.
   [Miyai, Nobuyuki; Morioka, Ikuharu; Utsumi, Miyoko; Hattori, Sonomi; Arita, Mikio] Wakayama Med Univ, Sch Hlth & Nursing Sci, Wakayama, Japan.
C3 Wakayama Medical University; Wakayama Medical University
RP Shiozaki, M (corresponding author), Wakayama Med Univ, Sch Med, Dept Hyg, Wakayama, Japan.; Shiozaki, M (corresponding author), Wakayama Prefectural Police, Welf Div, Wakayama, Japan.
EM miyain@wakayama-med.ac.jp
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NR 50
TC 15
Z9 21
U1 1
U2 15
PU NATL INST OCCUPATIONAL SAFETY & HEALTH, JAPAN
PI KAWASAKI KANAGAWA
PA 21-1 NAGAO 6-CHOME TAMA-KU, KAWASAKI KANAGAWA, 214, JAPAN
SN 0019-8366
EI 1880-8026
J9 IND HEALTH
JI Ind. Health
PD JUL
PY 2017
VL 55
IS 4
BP 369
EP 380
PG 12
WC Environmental Sciences; Public, Environmental & Occupational Health;
   Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health; Toxicology
GA FC4PZ
UT WOS:000406824200008
PM 28428501
OA Green Submitted, gold, Green Published
DA 2025-06-11
ER

PT J
AU Vlasiuk, E
   Zawari, M
   Whitehead, R
   Williman, J
   Carr, AC
AF Vlasiuk, Emma
   Zawari, Masuma
   Whitehead, Rebekah
   Williman, Jonathan
   Carr, Anitra C.
TI A High Vitamin C Micronutrient Supplement Is Unable to Attenuate
   Inflammation in People with Metabolic Syndrome but May Improve Metabolic
   Health Indices: A Randomised Controlled Trial
SO ANTIOXIDANTS
LA English
DT Article
DE metabolic syndrome; obesity; inflammation; C-reactive protein; vitamin
   C; micronutrients; glycaemic indices; insulin sensitivity; metabolic
   severity score
ID 3RD NATIONAL-HEALTH; OXIDATIVE STRESS; ANTIOXIDANT SUPPLEMENTATION;
   RISK; METAANALYSIS; DEFINITION; MANAGEMENT; EXERCISE; PROTEIN
AB Chronic low-grade inflammation is a characteristic of people with metabolic syndrome and is thought to contribute to the condition progressing to the more severe type 2 diabetes and cardiovascular disease (CVD). The aim was to carry out a double-blind randomised placebo-controlled trial in people with metabolic syndrome to determine if supplementation with a micronutrient formula containing 1000 mg/d vitamin C could attenuate inflammation in people with metabolic syndrome. We recruited 72 adults aged a median of 52 years with metabolic syndrome, defined as obesity (based on waist circumference or BMI), and at least two of hyperglycaemia, raised triglycerides, lowered HDL cholesterol, hypertension, or taking medications for these conditions. A further inclusion criteria comprised C-reactive protein (CRP) concentrations >= 3 mg/L, i.e., high risk of CVD. The participants were randomised to daily micronutrient formula (n = 37) or matched placebo control (n = 35) for 12 weeks. The primary outcome was change in CRP concentrations and secondary outcomes included changes in vitamin C concentrations, pro-inflammatory cytokines (IL-6, TNF alpha), oxidative stress marker (F(2)isoprostanes), glycaemic indices (glucose, insulin, HbA1c), lipid markers (triglycerides, LDL and HDL cholesterol), anthropometric parameters (weight, BMI), insulin resistance and insulin sensitivity, and metabolic severity score. The participants had a low median (Q1, Q3) vitamin C status of 29 (15, 41) mu mol/L and a high proportion of hypovitaminosis C (38%) and outright deficiency (19%). Following 12 weeks of micronutrient supplementation, at least 70% of the participants reached adequate vitamin C status (>= 50 mu mol/L), however, there was no change in CRP concentrations relative to the placebo group (Delta-0.3 [95%CI -2.7, 2.1] mg/L, p = 0.8). Similar trends were observed for IL-6, TNF alpha and F(2)isoprostanes (p > 0.05). Instead, there were small improvements in BMI, fasting glucose and HbA1c concentrations, insulin sensitivity and metabolic severity score in the micronutrient group relative to placebo (p < 0.05). Overall, 12-week micronutrient supplementation was unable to mitigate systemic inflammation in people with metabolic syndrome but may improve several metabolic health indices.
C1 [Vlasiuk, Emma; Zawari, Masuma; Whitehead, Rebekah; Carr, Anitra C.] Univ Otago, Nutr Med Res Grp, Dept Pathol & Biomed Sci, Christchurch 8011, New Zealand.
   [Williman, Jonathan] Univ Otago, Dept Populat Hlth, Christchurch 8011, New Zealand.
C3 University of Otago; University of Otago
RP Carr, AC (corresponding author), Univ Otago, Nutr Med Res Grp, Dept Pathol & Biomed Sci, Christchurch 8011, New Zealand.
EM emma.vlasiuk@otago.ac.nz; masuma.zawari@otago.ac.nz;
   whibe325@student.otago.ac.nz; jonathan.williman@otago.ac.nz;
   anitra.carr@otago.ac.nz
RI ; Williman, Jonathan/E-8206-2016
OI , Anitra/0000-0002-5890-2977; Vlasiuk, Emma/0000-0001-7712-5643;
   Williman, Jonathan/0000-0001-5080-4435
FU Bayer Consumer Care
FX We thank Catherine Wall for advice on nutrient analysis and Emily Brown
   and Monique Kuik for assistance with analysis of dietary questionnaires.
   We also thank John Cook for general practice advice.
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NR 56
TC 4
Z9 4
U1 3
U2 6
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD APR
PY 2024
VL 13
IS 4
AR 404
DI 10.3390/antiox13040404
PG 17
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA OZ5T0
UT WOS:001211118500001
PM 38671852
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Liu, ZH
   Li, QH
   Zhao, F
   Chen, JH
AF Liu, Zhihao
   Li, Qihao
   Zhao, Fu
   Chen, Jihang
TI A decade review on phytochemistry and pharmacological activities of
   Cynomorium songaricum Rupr.: Insights into metabolic syndrome
SO PHYTOMEDICINE
LA English
DT Article
DE Active compounds; Metabolic syndrome; Phytochemistry; Pharmacology;
   Therapeutic effects
ID ENDOPLASMIC-RETICULUM STRESS; GRAPE SEED PROANTHOCYANIDIN; NF-KAPPA-B;
   ADIPOSE-TISSUE; INSULIN-RESISTANCE; OXIDATIVE STRESS;
   SIGNAL-TRANSDUCTION; ALPHA-GLUCOSIDASE; FREE-RADICALS; OBESE MICE
AB Background: Cynomorium songaricum Rupr. (CSR), a perennial herb with a rich history in traditional medicine, has demonstrated therapeutic potential against metabolic syndrome (MetS) through its active compounds, including proanthocyanidins, polysaccharides, and triterpenoids. MetS, a global health concern, encompasses interlinked conditions such as obesity, type 2 diabetes mellitus (T2DM), and inflammation. This review synthesizes recent findings on CSR's pharmacological and phytochemical properties, focusing on its role in ameliorating MetS. Methods: Following Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines, relevant studies were retrieved from PubMed, Web of Science, and CNKI databases up to December 2024. Keywords included "Cynomorium Songaricum Rupr.", "Cynomorii Herba", "Suoyang", "Suo Yang", "Metabolic syndrome", "Proanthocyanidins", "Polysaccharides" and "Triterpenoids" and their combinations. Inclusion criteria emphasized studies exploring CSR's impact on MetS, while duplicate, low-quality studies and studies not written in Chinese, English, or unrelated were excluded. Results: A total of 92 studies were analyzed, revealing that CSR's active components exhibit multi-target effects. Proanthocyanidins reduce glucose absorption and oxidative stress, polysaccharides enhance insulin sensitivity and gut microbiota composition, and triterpenoids mitigate obesity and mitochondria damage. These mechanisms collectively contribute to the beneficial effects of CSR against MetS. Conclusion: CSR presents a promising natural therapy for MetS, utilizing its pharmacologically active compounds to address core metabolic dysfunctions. Future studies should focus on clinical validation and safety assessments to facilitate CSR's integration into modern therapeutic regimens.
C1 [Liu, Zhihao; Li, Qihao; Zhao, Fu; Chen, Jihang] Chinese Univ Hong Kong, Sch Med, Shenzhen, Peoples R China.
   [Liu, Zhihao; Chen, Jihang] Chinese Univ Hong Kong, Shenzhen Futian Biomed Innovat R&D Ctr, Shenzhen, Peoples R China.
C3 The Chinese University of Hong Kong, Shenzhen; The Chinese University of
   Hong Kong, Shenzhen
RP Chen, JH (corresponding author), Chinese Univ Hong Kong Shenzhen, 2001 Longxiang Ave, Shenzhen, Guangdong, Peoples R China.
EM chenjihang@cuhk.edu.cn
RI Liu, Zhihao/MHQ-6474-2025; Chen, Jihang/LWH-6308-2024
FU National Natural Science Foundation of China [82274160]; Guangdong
   Natural Science Foundation [2023A1515011492]; Shenzhen Fundamental
   Research Program [JCYJ20210324121201004, JCYJ20230807114103007];
   Shenzhen Science and Technology Program [GJHZ20240218114200001];
   Shenzhen-Hong Kong Cooperation Zone for Technology and Innovation
   [HZQB-KCZYB-2020056]
FX This work was supported by the research grants from the National Natural
   Science Foundation of China (Grant No. 82274160) , Guangdong Natural
   Science Foundation (2023A1515011492) , Shenzhen Fundamental Research
   Program (Grant No. JCYJ20210324121201004, JCYJ20230807114103007) ,
   Shenzhen Science and Technology Program (GJHZ20240218114200001) and
   Shenzhen-Hong Kong Cooperation Zone for Technology and Innovation
   (HZQB-KCZYB-2020056) .
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NR 146
TC 1
Z9 1
U1 7
U2 7
PU ELSEVIER GMBH
PI MUNICH
PA HACKERBRUCKE 6, 80335 MUNICH, GERMANY
SN 0944-7113
EI 1618-095X
J9 PHYTOMEDICINE
JI Phytomedicine
PD MAY
PY 2025
VL 140
AR 156602
DI 10.1016/j.phymed.2025.156602
EA MAR 2025
PG 18
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA 0BM1M
UT WOS:001443409100001
PM 40058318
DA 2025-06-11
ER

PT J
AU Huang, HR
   Han, XQ
   Liu, QY
   Xue, JL
   Yu, ZL
   Miao, SF
AF Huang, Huirong
   Han, Xueqi
   Liu, Qinyu
   Xue, Jialu
   Yu, Zhenling
   Miao, Shaofang
TI Associations between metabolic syndrome and female stress urinary
   incontinence: a meta-analysis
SO INTERNATIONAL UROGYNECOLOGY JOURNAL
LA English
DT Review
DE Stress urinary incontinence; Metabolic syndrome; Females; Meta-analysis
ID COMPONENTS; SYMPTOMS; PROLAPSE; WOMEN
AB Introduction and hypothesis The objective was to identify the associations between metabolic syndrome (MS) and stress urinary incontinence (SUI) in women and to provide an evidence base for clinical practice. Methods A meta-analysis of cohort, case-control, and cross-sectional studies about the association between MS and SUI was performed using databases including PubMed, Cochrane Library, Web of Science, Embase, China National Knowledge Infrastructure (CNKI), China Biology Medicine disc (CBMdisc), Wanfang Database (WanFang Data), and VIP database (VIP). The time limit was from the commencement of each database to 1 November 2020. Two researchers independently screened literature, extracted data, and assessed the risk of bias. RevMan 5.3 software was used for statistical analysis. The dichotomous variables were presented as the risk ratio (odds ratio, OR) and 95% CI as the effect indicators. Results Six studies were included in the meta-analysis, with a total sample size of 3,678 cases. The results showed that the risk for SUI in women with MS was three times those without MS (OR = 3.41, 95% CI 2.01, 5.77, p <0.00001), and the difference was statistically significant. The results of subgroup analysis showed that MS was significantly associated with SUI in the subgroups of pre- and postmenopausal women (OR = 2.46, 95% CI 1.63, 3.73, p < 0.00001), and in the subgroups of other types of women (OR = 3.41, 95% CI 2.01, 5.77, p = 0.0003), and the differences were statistically significant. Conclusions Metabolic syndrome is associated with SUI in women and increases its risk.
C1 [Huang, Huirong; Miao, Shaofang] Fujian Univ Tradit Chines, Peoples Hosp, 602,817 Middle Rd, Fuzhou 350004, Fujian, Peoples R China.
   [Han, Xueqi] Shandong Open Univ, Jinan 250014, Shandong, Peoples R China.
   [Liu, Qinyu] First Peoples Hosp Chongqing Liang Jiang New Area, Chongqing 401121, Peoples R China.
   [Xue, Jialu; Yu, Zhenling] Fujian Univ Tradit Chinese Med, Sch Nursing, Fuzhou 350122, Fujian, Peoples R China.
C3 Fujian University of Traditional Chinese Medicine
RP Huang, HR (corresponding author), Fujian Univ Tradit Chines, Peoples Hosp, 602,817 Middle Rd, Fuzhou 350004, Fujian, Peoples R China.
EM 1436682921@qq.com
RI Huang, huirong/AGK-2284-2022
OI huang, huirong/0000-0003-2161-9999
FU Special research project of the National Clinical Research Base of
   Traditional Chinese Medicine in 2019 [JDZX201920]
FX This study was funded by a Special research project of the National
   Clinical Research Base of Traditional Chinese Medicine in 2019 (grant
   number JDZX201920).
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NR 18
TC 9
Z9 9
U1 0
U2 11
PU SPRINGER LONDON LTD
PI LONDON
PA 236 GRAYS INN RD, 6TH FLOOR, LONDON WC1X 8HL, ENGLAND
SN 0937-3462
EI 1433-3023
J9 INT UROGYNECOL J
JI Int. Urogynecol. J.
PD AUG
PY 2022
VL 33
IS 8
BP 2073
EP 2079
DI 10.1007/s00192-021-05025-0
EA FEB 2022
PG 7
WC Obstetrics & Gynecology; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology; Urology & Nephrology
GA 3M7JV
UT WOS:000751598900001
PM 35122481
DA 2025-06-11
ER

PT J
AU Kaluzna, M
   Nomejko, A
   Slowinska, A
   Wachowiak-Ochmanska, K
   Pikosz, K
   Ziemnicka, K
   Ruchala, M
AF Kaluzna, Malgorzata
   Nomejko, Agnieszka
   Slowinska, Aleksandra
   Wachowiak-Ochmanska, Katarzyna
   Pikosz, Katarzyna
   Ziemnicka, Katarzyna
   Ruchala, Marek
TI Lower sexual satisfaction in women with polycystic ovary syndrome and
   metabolic syndrome
SO ENDOCRINE CONNECTIONS
LA English
DT Article
DE polycystic ovary syndrome (PCOS); health-related quality of life
   (HRQoL); WHO quality of life-BREF (WHOQOL-BREF); sexual satisfaction;
   sexual satisfaction; questionnaire (SSQ)
ID QUALITY-OF-LIFE; SELF-ESTEEM; HEALTH; DYSFUNCTION; DEPRESSION; ANXIETY;
   PREVALENCE; SAMPLE; RISKS; PCOS
AB Background: Polycystic ovary syndrome (PCOS) is a multi-symptom disorder linked with a range of metabolic and hormonal disturbances. Psychological and sexual aspects of PCOS also need to be considered.
   Objective of the study: This study aimed to assess sexual satisfaction (SS) in PCOS patients and eumenorrheic controls (CON). The relationships between SS, depressive symptoms, health-related quality of life (HRQoL), and hormonal and metabolic profiles were evaluated.
   Methods: In this study, 190 patients with PCOS (mean age 26.34 +/- 5.47 years) and 197 age-matched CON (mean age 27.12 +/- 4.97 years) were enrolled. All subjects completed Polish version of the Sexual Satisfaction Questionnaire (SSQ), WHO Quality of Life-BREF (WHOQOL-BREF), and the Center for Epidemiologic Studies Depression Scale-Revised (CESD-R) questionnaire. Fasting blood samples were collected to assess hormonal, lipid, and glucose profiles. Anthropometric measures were collected. Metabolic syndrome (MS) was evaluated according to the IDF-AHA/NHLBI criteria.
   Results: Patients with PCOS and MS had lower SS vs non-MS-PCOS. There were no significant differences in the level of SS, presence of depressive symptoms, or HRQoL between PCOS and CON ( P > 0.05). Negative correlations were found between the SS level and BMI, waist circumference, and waist-to-height ratio in PCOS women. However, overweight or obese PCOS women did not differ in SS levels vs normal-weight PCOS patients. The social dimension of WHOQOL-BREF was the only significant predictor of SS in PCOS patients.
   Conclusions: SS in PCOS women appears to be undisturbed. However, MS in PCOS patients could negatively influence SS. The level of SS should be assessed in PCOS women, especially if MS is present.
C1 [Kaluzna, Malgorzata; Ziemnicka, Katarzyna; Ruchala, Marek] Poznan Univ Med Sci, Dept Endocrinol Metab & Internal Dis, Poznan, Poland.
   [Nomejko, Agnieszka; Slowinska, Aleksandra] Univ Wroclaw, Fac Pedag & Hist Sci, Inst Psychol, Wroclaw, Poland.
   [Wachowiak-Ochmanska, Katarzyna] Heliodor Swiecicki Univ Hosp, Endocrinol Metab & Internal Dis Ward, Poznan, Poland.
   [Pikosz, Katarzyna] Poznan Univ Med Sci, Dept Pharmacognosy, Poznan, Poland.
C3 Poznan University of Medical Sciences; University of Wroclaw; Poznan
   University of Medical Sciences
RP Kaluzna, M (corresponding author), Poznan Univ Med Sci, Dept Endocrinol Metab & Internal Dis, Poznan, Poland.
EM kaluznama@gmail.com
OI Nomejko, Agnieszka/0000-0003-0254-9892; Slowinska,
   Aleksandra/0000-0002-9498-501X
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NR 60
TC 3
Z9 3
U1 1
U2 5
PU BIOSCIENTIFICA LTD
PI BRISTOL
PA STARLING HOUSE, 1600 BRISTOL PARKWAY N, BRISTOL, ENGLAND
EI 2049-3614
J9 ENDOCR CONNECT
JI Endocr. Connect.
PD SEP
PY 2021
VL 10
IS 9
BP 1035
EP 1044
DI 10.1530/EC-21-0257
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism
GA WC9HK
UT WOS:000704561100010
PM 34319905
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Dauden, E
   Lazaro, P
   Aguilar, MD
   Blasco, AJ
   Suarez, C
   Marin, I
   Queiro, R
   Bassas-Vila, J
   Martorell, A
   García-Campayo, J
AF Dauden, E.
   Lazaro, P.
   Aguilar, M. D.
   Blasco, A. J.
   Suarez, C.
   Marin, I.
   Queiro, R.
   Bassas-Vila, J.
   Martorell, A.
   Garcia-Campayo, J.
TI Recommendations for the management of comorbidity in hidradenitis
   suppurativa
SO JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
LA English
DT Article
ID INFLAMMATORY-BOWEL-DISEASE; QUALITY-OF-LIFE; METABOLIC SYNDROME;
   ARTERIAL-HYPERTENSION; PREVALENCE; RISK; SPONDYLOARTHRITIS; ASSOCIATION;
   DEPRESSION; DIAGNOSIS
AB Background The association between hidradenitis suppurativa (HS) and some diseases is becoming relevant in recent years. Providing appropriate management of HS from an early stage requires to include prompt diagnosis and treatment of concomitant diseases and to prevent any potential comorbidity. This approach should consider the adverse events of the drugs used to treat HS potentially related to the onset of a comorbidity.
   Objective To provide the dermatologist with an accurate, easily used tool that will inform the diagnosis of HS comorbidity, and to facilitate decision-making regarding the referral and treatment of patient with HS-associated comorbidity.
   Methods These recommendations have been developed by a working group composed of seven experts (three dermatologists, a cardiovascular specialist internist, a rheumatologist expert in spondyloarthritis, a gastroenterologist and a psychiatrist) and a team of three methodologist researchers. The expert group selected the HS comorbidities considered in these recommendations through a literature review. The recommendations on diagnostic criteria are based on the relevant clinical practice guidelines for each of the comorbidities and on the recommendations of the experts. The information regarding the repercussion of HS medical treatments on associated comorbid diseases was obtained from the summary of product characteristics of each drug.
   Results The comorbidities considered in this guide are as follows: cardiovascular risk factors (diabetes, dyslipidaemia, obesity, hypertension and metabolic syndrome), inflammatory bowel disease, inflammatory joint disorders and psychological disorders (anxiety and depression). In addition, the association between HS and the consumption of alcohol and tobacco is included. The tables and figures are a precise, easy-to-use tool to systematize the diagnosis of comorbidity in patients with HS and facilitate the decision-making process regarding referral and treatment of patients with an associated disease.
   Conclusion The application of these recommendations will facilitate the dermatologist practice and benefit HS patients' health and quality of life.
C1 [Dauden, E.] Hosp Univ Princesa, Inst Invest Sanitaria Princesa IIS IP, Dept Dermatol, Madrid, Spain.
   [Lazaro, P.; Aguilar, M. D.; Blasco, A. J.] Hlth Serv Res, Madrid, Spain.
   [Suarez, C.] UAM, Hosp Univ Princesa, Inst Invest Sanitaria Princesa IIS IP, Dept Internal Med, Madrid, Spain.
   [Marin, I.] Inst Invest Sanitaria Gregorio Maranon, Dept Gastroenterol, Madrid, Spain.
   [Queiro, R.] Hosp Univ Cent Asturias, Rheumatol Div, Oviedo, Spain.
   [Bassas-Vila, J.] Autonomous Univ Barcelona, Hosp Univ Germans Trias & Pujol, Dept Dermatol, Barcelona, Spain.
   [Martorell, A.] Hosp Manises, Dept Dermatol, Valencia, Spain.
   [Garcia-Campayo, J.] Univ Zaragoza, Miguel Servet Univ Hosp, Aragonese Inst Hlth Sci, Zaragoza, Spain.
C3 Hospital de La Princesa; Autonomous University of Madrid; Hospital de La
   Princesa; Central University Hospital Asturias; Autonomous University of
   Barcelona; Hospital Germans Trias i Pujol; Miguel Servet University
   Hospital; University of Zaragoza
RP Lazaro, P (corresponding author), Hlth Serv Res, Madrid, Spain.
EM plazaro@gmx.es
RI Martorell Calatayud, Antonio/JLK-9722-2023; Bassas-Vila,
   Julio/AEP-5070-2022; Queiro, Ruben/D-5358-2016
OI Garcia-Campayo, Javier/0000-0002-3797-4218; Martorell,
   Antonio/0000-0003-1378-1590; Bassas-Vila, Julio/0000-0003-2787-750X;
   Queiro, Ruben/0000-0002-8418-7145
FU AbbVie
FX This project has received financial support from AbbVie. AbbVie had no
   influence on the development of the manuscript.
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NR 68
TC 39
Z9 40
U1 0
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0926-9959
EI 1468-3083
J9 J EUR ACAD DERMATOL
JI J. Eur. Acad. Dermatol. Venereol.
PD JAN
PY 2018
VL 32
IS 1
BP 129
EP 144
DI 10.1111/jdv.14517
PG 16
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA FS9WZ
UT WOS:000422771300048
PM 28796920
DA 2025-06-11
ER

PT J
AU Green, BB
   Armstrong, DA
   Lesseur, C
   Paquette, AG
   Guerin, DJ
   Kwan, LE
   Marsit, CJ
AF Green, Benjamin B.
   Armstrong, David A.
   Lesseur, Corina
   Paquette, Alison G.
   Guerin, Dylan J.
   Kwan, Lauren E.
   Marsit, Carmen J.
TI The Role of Placental 11-Beta Hydroxysteroid Dehydrogenase Type 1 and
   Type 2 Methylation on Gene Expression and Infant Birth Weight
SO BIOLOGY OF REPRODUCTION
LA English
DT Article
DE developmental origins of health and disease; glucocorticoids;
   glucocorticoid receptor; metabolic syndrome; stress
ID INTRAUTERINE GROWTH RESTRICTION; 11-BETA-HYDROXYSTEROID DEHYDROGENASE;
   DNA METHYLATION; PRENATAL STRESS; PROMOTER; PREGNANCIES; ANXIETY;
   CYTOSINES; CHILDREN; IMPACT
AB Maternal stress has been linked to infant birth weight outcomes, which itself may be associated with health later in life. The placenta acts as a master regulator for the fetal environment, mediating intrauterine exposures to stress through the activity of genes regulating glucocorticoids, including the 11beta-hydroxysteroid dehydrogenase (HSD11B) type 1 and 2 genes, and so we hypothesized that variation in these genes will be associated with infant birth weight. We investigated DNA methylation levels at six sites across the two genes, as well as mRNA expression for each, and the relationship to infant birth weight. Logistic regressions correcting for potential confounding factors revealed a significant association between methylation at a single CpG site within HSD11B1 and being born large for gestational age. In addition, our analysis identified correlations between methylation and gene expression, including sex-specific transcriptional regulation of HSD11B2. Our work is one of the first comprehensive views of DNA methylation and expression in the placenta for both HSD11B types 1 and 2, linking epigenetic alterations with the regulation of fetal stress and birth weight outcomes.
C1 Dartmouth Coll, Geisel Sch Med, Dept Pharmacol & Toxicol, Hanover, NH 03755 USA.
   Dartmouth Coll, Geisel Sch Med, Dept Epidemiol, Hanover, NH 03755 USA.
C3 Dartmouth College; Dartmouth College
RP Marsit, CJ (corresponding author), Dartmouth Coll, Geisel Sch Med, HB 7650, Hanover, NH 03755 USA.
EM carmen.j.marsit@dartmouth.edu
RI Lesseur, Corina/W-1034-2019
OI Lesseur, Corina/0000-0001-6744-6750; Marsit, Carmen/0000-0003-4566-150X
FU National Institutes of Health (NIH)/National Institute of Mental Health
   grant [R01MH094609]; NIH/National Institute of Environmental Health
   Sciences (NIEHS) grant [R01ES022223]; NIH/National Cancer Institute
   grant [R25CA134286]; NIH/NIEHS grant [P01 ES022832]; U.S. Environmental
   Protection Agency (EPA) [RD83544201]
FX Supported by National Institutes of Health (NIH)/National Institute of
   Mental Health grant R01MH094609, NIH/National Institute of Environmental
   Health Sciences (NIEHS) grant R01ES022223, NIH/National Cancer Institute
   grant R25CA134286 to B.B.G., NIH/NIEHS grant P01 ES022832, and by U.S.
   Environmental Protection Agency (EPA) grant RD83544201. The EPA does not
   endorse the purchase of any commercial products or services mentioned in
   this publication.
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NR 38
TC 44
Z9 48
U1 0
U2 8
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0006-3363
EI 1529-7268
J9 BIOL REPROD
JI Biol. Reprod.
PD JUN 1
PY 2015
VL 92
IS 6
AR 149
DI 10.1095/biolreprod.115.128066
PG 8
WC Reproductive Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Reproductive Biology
GA CK8LT
UT WOS:000356490300016
PM 25788665
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Schuch, FB
   Stubbs, B
AF Schuch, Felipe Barreto
   Stubbs, Brendon
TI The Role of Exercise in Preventing and Treating Depression
SO CURRENT SPORTS MEDICINE REPORTS
LA English
DT Review
ID PHYSICAL-ACTIVITY INTERVENTIONS; SEVERE MENTAL-ILLNESS; MAJOR
   DEPRESSION; BIPOLAR DISORDER; CARDIORESPIRATORY FITNESS; ANTIDEPRESSANT
   TREATMENT; AUGMENTATION TREATMENT; SEDENTARY BEHAVIOR; METABOLIC
   SYNDROME; ALL-CAUSE
AB Depression is a leading cause of global burden. The mainstay of treatment is pharmacological and psychological interventions. While effective, not all people will respond to those treatments and alternative approaches for preventing and treating depression are required. Recent literature has demonstrated that higher physical activity (PA) levels and exercise confer protective effects on incident depression. Also, exercise has demonstrated efficacy on reducing symptoms for people with depression. Despite its effectiveness, similar to other treatments, some people may benefit more from exercise and identifying these potential predictors of response is necessary to deal with patients' and professionals' expectations. Dropout from exercise interventions is comparable to dropout from other treatments for depression and similar to dropout from exercise in other clinical populations. However, some strategies to increase adherence are important. In the present article, we provide an updated overview of the use of PA and exercise for the prevention and treatment of depression.
C1 [Schuch, Felipe Barreto] Univ Fed Santa Maria, Dept Sports Methods & Tech, Santa Maria, RS, Brazil.
   [Stubbs, Brendon] Kings Coll London, Inst Psychiat Psychol & Neurosci, De Crespigny Pk, London, England.
   [Stubbs, Brendon] South London & Maudsley NHS Fdn Trust, Denmark Hill, London, England.
C3 Universidade Federal de Santa Maria (UFSM); University of London; King's
   College London
RP Schuch, FB (corresponding author), Univ Fed Santa Maria, Ave Roraima,1000 CEFD,Cidade Univ, BR-97105900 Santa Maria, RS, Brazil.
EM felipe.schuch@ufsm.br
RI Stubbs, Brendon/X-1904-2018; Schuch, Felipe/AAF-5028-2019; Stubbs,
   Brendon/C-5696-2015; Schuch, Felipe/L-4620-2016
OI Stubbs, Brendon/0000-0001-7387-3791; Schuch, Felipe/0000-0002-5190-4515
FU Coordination of Improvement of Higher Education Personnel - Brazil
   (CAPES); Health Education England; National Institute for Health
   Research HEE/NIHR ICA Programme Clinical Lectureship
   [ICA-CL-2017-03-001]; National Institute for Health Research (NIHR)
   Collaboration for Leadership in Applied Health Research and Care South
   London (NIHR CLAHRC South London) at King's College Hospital NHS
   Foundation Trust
FX The present study was carried out with the support of the Coordination
   of Improvement of Higher Education Personnel - Brazil (CAPES). B.S. is
   supported by Health Education England and the National Institute for
   Health Research HEE/NIHR ICA Programme Clinical Lectureship
   (ICA-CL-2017-03-001). B.S. also is supported by the National Institute
   for Health Research (NIHR) Collaboration for Leadership in Applied
   Health Research and Care South London (NIHR CLAHRC South London) at
   King's College Hospital NHS Foundation Trust. The views expressed in
   this publication are those of the author(s) and not necessarily those of
   the NHS, the National Institute for Health Research or the Department of
   Health and Social Care.
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NR 66
TC 147
Z9 167
U1 4
U2 80
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1537-890X
EI 1537-8918
J9 CURR SPORT MED REP
JI Curr. Sport. Med. Rep.
PD AUG
PY 2019
VL 18
IS 8
BP 299
EP 304
DI 10.1249/JSR.0000000000000620
PG 6
WC Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Sport Sciences
GA IO0DY
UT WOS:000479050800006
PM 31389872
OA Bronze
DA 2025-06-11
ER

PT J
AU Kuppili, PP
   Menon, V
   Chandrasekaran, V
   Navin, K
AF Kuppili, Pooja Patnaik
   Menon, Vikas
   Chandrasekaran, Vigneshvar
   Navin, Karthick
TI Biological rhythm impairment in bipolar disorder: A state or trait
   marker?
SO INDIAN JOURNAL OF PSYCHIATRY
LA English
DT Article
DE Biological rhythms; functioning; metabolic syndrome; subsyndromal
   depression; trait marker
ID METABOLIC SYNDROME; MOOD DISORDERS; RATING-SCALE; MEDICATIONS;
   COMMUNITY; SLEEP
AB Context: There is limited research on biological rhythms in bipolar disorder (BD) from the Indian setting despite its intricate relationship with metabolic syndrome (MS) and functioning. Aims: The study aimed to assess " trait marker" status of biological rhythms as well as correlates of biological rhythm impairment in euthymic BD. Setting and Design: Cross-sectional observational study over 6 months was carried out in hospital setting. Materials and Methods: Biological Rhythms Interview of Assessment in Neuropsychiatry Questionnaire (BRIAN) and Functioning Assessment Short Test (FAST) were used to assess biological rhythms and functioning, respectively. MS was diagnosed as per modified National Cholesterol Education Program-Adult Treatment Panel III. Depressive symptoms were assessed by the Hamilton Depression Rating Scale (HDRS). Euthymia was defined as symptomatic remission for at least 8 weeks. Ethical approval was taken. Results: Fifty cases of euthymic BD and fifty apparently healthy controls were recruited. Total as well as certain domain-specific BRIAN and FAST scores were significantly higher in cases compared to controls. A significant positive correlation was found between the total BRIAN score with HDRS as well as FAST score. No correlation was obtained between biological rhythms and metabolic parameters. Conclusions: Our results support the hypothesis that biological rhythm impairment is a trait marker in patients with BD. The study supports the need for management of subsyndromal depressive symptoms even in inter-episodic period.
C1 [Kuppili, Pooja Patnaik] All India Inst Med Sci, Dept Psychiat, Jodhpur, Rajasthan, India.
   [Menon, Vikas; Chandrasekaran, Vigneshvar; Navin, Karthick] Jawaharlal Inst Post Grad Med Educ & Res, Dept Psychiat, Pondicherry 605006, India.
C3 All India Institute of Medical Sciences (AIIMS) Jodhpur; Jawaharlal
   Institute of Postgraduate Medical Education & Research
RP Menon, V (corresponding author), Jawaharlal Inst Post Grad Med Educ & Res, Dept Psychiat, Pondicherry 605006, India.
EM drvmenon@gmail.com
RI Menon, Vikas/F-3100-2012; Chandrasekaran, Vigneshvar/AAH-9375-2019
OI Chandrasekaran, Vigneshvar/0000-0001-5024-6330
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NR 33
TC 7
Z9 7
U1 0
U2 5
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, 400059, INDIA
SN 0019-5545
EI 1998-3794
J9 INDIAN J PSYCHIAT
JI Indian J. Psychiatry
PD OCT-DEC
PY 2018
VL 60
IS 4
BP 404
EP 409
DI 10.4103/psychiatry.IndianJPsychiatry_110_18
PG 6
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA HD8HA
UT WOS:000452794600006
PM 30581205
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Gurusamy, J
   Gandhi, S
   Damodharan, D
   Palaniappan, M
   Venkatasubramanian, G
AF Gurusamy, Jothimani
   Gandhi, Sailaxmi
   Damodharan, Dinakaran
   Palaniappan, Marimuthu
   Venkatasubramanian, Ganesan
TI Grounded theory of 'lifestyle adaptation' - Perspectives from persons
   with schizophrenia and their caregivers
SO ASIAN JOURNAL OF PSYCHIATRY
LA English
DT Article
DE Lifestyle adaptation; Perspectives; Schizophrenia; Family caregivers;
   Grounded theory
ID METABOLIC SYNDROME; MENTAL-ILLNESS; INTERVENTION; FACILITATORS; PEOPLE;
   RISK
AB Introduction: Available evidence highlights that persons diagnosed with schizophrenia are predisposed to develop physical co-morbidities. Lifestyle modification interventions are identified as appropriate strategies to maintain their physical health. A comprehensive understanding of the facilitators and barriers in adhering to healthy lifestyle interventions is critical to developing individualized interventions that are effective and accessible for these patients.
   Aim: To develop and formulate a theory of lifestyle adaptation for the prevention of physical co-morbidities for persons with schizophrenia and their caregivers who are availing mental health services in the psychiatry wards.
   Materials and methods: The qualitative data were collected by semi-structured interviews using topic guides from persons with schizophrenia and their family caregivers from the tertiary level psychiatry center, South India. The interviews explored their perceptions and experiences of the facilitators and barriers in adopting a healthy lifestyle. Final data was analyzed based on grounded theory, and the data was used to formulate the theory of lifestyle adaptation.
   Conclusion: The persons with schizophrenia and their family caregivers' perceptions helped in formulating this theory. The present study provides recommendations for physical health services for patients with mental illness. The findings of the study may guide health professionals and mental health advocacy groups, policymakers to plan for appropriate decisions related to incorporating mental health care with physical health care services
C1 [Gurusamy, Jothimani] Natl Inst Mental Hlth & Neurosci, Coll Nursing, Bangalore, Karnataka, India.
   [Gandhi, Sailaxmi] Natl Inst Mental Hlth & Neurosci, Dept Nursing, Bangalore, Karnataka, India.
   [Damodharan, Dinakaran; Venkatasubramanian, Ganesan] Natl Inst Mental Hlth & Neurosci, Dept Psychiat, Bangalore, Karnataka, India.
   [Palaniappan, Marimuthu] Natl Inst Mental Hlth & Neurosci, Dept Biostat, Bangalore, Karnataka, India.
C3 National Institute of Mental Health & Neurosciences - India; National
   Institute of Mental Health & Neurosciences - India; National Institute
   of Mental Health & Neurosciences - India; National Institute of Mental
   Health & Neurosciences - India
RP Gurusamy, J (corresponding author), Natl Inst Mental Hlth & Neurosci, Coll Nursing, Bangalore, Karnataka, India.
EM jothisrinivas.jothi@gmail.com
RI Gurusamy, Jothimani/P-6729-2019; Venkatasubramanian,
   Ganesan/AAD-9117-2019
OI Gurusamy, Jothimani/0000-0002-3844-6038; Venkatasubramanian,
   Ganesan/0000-0002-0949-898X
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NR 21
TC 5
Z9 5
U1 0
U2 8
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1876-2018
EI 1876-2026
J9 ASIAN J PSYCHIATR
JI Asian J. Psychiatr.
PD FEB
PY 2021
VL 56
AR 102511
DI 10.1016/j.ajp.2020.102511
EA JAN 2021
PG 6
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychiatry
GA QL4GF
UT WOS:000621036000026
PM 33412371
DA 2025-06-11
ER

PT J
AU Lee, LJ
   Kim, Y
   Shamburek, R
   Ross, A
   Yang, L
   Bevans, MF
AF Lee, Lena J.
   Kim, Youngmee
   Shamburek, Robert
   Ross, Alyson
   Yang, Li
   Bevans, Margaret F.
TI Caregiving stress and burden associated with cardiometabolic risk in
   family caregivers of individuals with cancer
SO STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS
LA English
DT Article
DE Cancer caregivers; caregiving stress; cardiometabolic biomarkers;
   nontraditional lipoprotein particle
ID CORONARY-HEART-DISEASE; PARTICLE NUMBER; BIOMARKERS; HEALTH;
   INTERVENTIONS; BEHAVIORS; MORBIDITY
AB Chronic stress is a well-established risk factor for cardiometabolic disease. Caregiving for individuals with cancer is perceived as a chronic stressor yet research on the risk for cardiometabolic disease in this population, opposed to the elderly and those with Alzheimer's disease, is limited. Additionally, few studies have explored the early physiological changes that occur in family caregivers suggesting an elevated risk for illness. This cross-sectional study was designed to examine levels of cardiometabolic risk biomarkers and their correlates in caregivers of patients with colorectal cancer. Caregivers completed questionnaires that measure exposures to stress and vulnerability factors, psychological distress, and health habits as potential correlates. Traditional lipid and nontraditional lipoprotein particle biomarkers (e.g. concentration and size for all lipoprotein classes) were assayed from blood serum. Caregivers (N = 83, mean age = 49.8, 73% female) displayed levels of cardiometabolic biomarkers that suggest an elevated risk for cardiometabolic disease. Caregivers who were Hispanic, married, highly educated, employed, reported more hours spent caregiving daily, experienced higher caregiver burden associated with the lack of family support and impact on schedule, and psychological distress, demonstrated an elevated risk for cardiometabolic disease; primarily determined by nontraditional lipid biomarkers - large TRL-P, LDL-P, small HDL-P, large HDL-P, TRL-Z, LDL-Z and HDL-Z. These findings suggest that traditional lipid biomarkers may not be robust enough to detect early physiological changes associated with cardiometabolic disease risk in family caregivers. Moreover, findings reiterate the importance of assessing caregiver burden and providing evidence-based interventions to manage caregiving stress with the potential to improve caregivers' cardiometabolic health.
C1 [Lee, Lena J.; Ross, Alyson; Yang, Li] NIH, Translat Biobehav & Hlth Dispar, Ctr Clin, Bethesda, MD 20892 USA.
   [Kim, Youngmee] Univ Miami, Dept Psychol, POB 248185, Coral Gables, FL 33124 USA.
   [Shamburek, Robert; Bevans, Margaret F.] NHLBI, Bldg 10, Bethesda, MD 20892 USA.
C3 National Institutes of Health (NIH) - USA; NIH Clinical Center (CC);
   University of Miami; National Institutes of Health (NIH) - USA; NIH
   National Heart Lung & Blood Institute (NHLBI)
RP Lee, LJ (corresponding author), NIH, Ctr Clin, 10 Ctr Dr, Bethesda, MD 20892 USA.
EM jumin.park@nih.gov
RI Yang, Li/KMG-3813-2024; Lee, Lena/ADJ-6635-2022
OI Yang, Li/0000-0002-4513-872X; Kim, Youngmee/0000-0002-3109-6362; Lee,
   Lena/0000-0002-2086-993X
FU American Cancer Society [121909-RSG-12-042-01-CPPB]; National Institute
   of Nursing Research [R01NR016838]; National Institute of Nursing
   Research [R01NR016838] Funding Source: NIH RePORTER
FX This research was supported by the American Cancer Society
   [121909-RSG-12-042-01-CPPB]. The writing of this manuscript was
   supported by National Institute of Nursing Research [R01NR016838] to YK.
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NR 41
TC 14
Z9 15
U1 2
U2 3
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1025-3890
EI 1607-8888
J9 STRESS
JI Stress
PD JAN 2
PY 2022
VL 25
IS 1
BP 258
EP 266
DI 10.1080/10253890.2022.2037548
PG 9
WC Behavioral Sciences; Endocrinology & Metabolism; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Behavioral Sciences; Endocrinology & Metabolism; Neurosciences &
   Neurology
GA 2H0FQ
UT WOS:000813975500001
PM 35727023
OA Green Accepted, gold
DA 2025-06-11
ER

PT J
AU Dogan, ESK
   Kirzioglu, FY
   Dogan, B
   Fentoglu, Ö
   Kale, B
   Çarsancakli, SA
   Orhan, H
AF Dogan, Esra Sinem Kemer
   Kirzioglu, Fatma Yesim
   Dogan, Burak
   Fentoglu, Ozlem
   Kale, Banu
   Carsancakli, Suleyman Akif
   Orhan, Hikmet
TI The role of menopause on the relationship between metabolic risk factors
   and periodontal disease via salivary oxidative parameters
SO JOURNAL OF PERIODONTOLOGY
LA English
DT Article
DE Menopause; metabolic syndrome X; oxidative stress; periodontal diseases;
   risk factors; saliva
ID GINGIVAL CREVICULAR FLUID; TOTAL OXIDANT STATUS; LIPID-PEROXIDATION
   LEVELS; POSTMENOPAUSAL WOMEN; TOOTH LOSS; STRESS; ASSOCIATION; SERUM;
   MYELOPEROXIDASE; HEALTH
AB Background: Periodontal disease is shown to be aggravated by an increase in the count of metabolic risk factors. This study aims to evaluate the effects of metabolic risk factors on periodontal parameters and salivary oxidative stress markers related to menopausal status.
   Methods: One hundred and seventy-six women were categorized according to menopausal status, either premenopause (Pre/M) (n = 86) or postmenopause (Post/M) (n = 90). The count of metabolic risk factors was evaluated. Sociodemographics and systemic status were determined via questionnaire and medical records. After clinical periodontal measurements and saliva collection, myeloperoxidase (MPO), total oxidant status (TOS) and total antioxidant capacity (TAOC) were determined by enzyme-linked immunosorbent assay and automatic colorimetric method. Oxidative stress index (OSI) was also calculated.
   Results: The count of metabolic risk factors was higher in the Post/M group than the Pre/M group. Periodontal parameters and TOS levels were elevated by an increase in the count of metabolic risk factors. Multivariate regression analyses revealed that periodontal (clinical attachment level and missed teeth) and oxidative (MPO and OSI) parameters increased and TAOC levels decreased due to menopause. Additionally, positive relationships between periodontal and oxidative parameters were determined.
   Conclusion: These findings suggest that salivary oxidative stress level may be an indicator of worsened periodontal status related to menopause and the count of metabolic risk factors.
C1 [Dogan, Esra Sinem Kemer; Dogan, Burak] Mustafa Kemal Univ, Dept Periodontol, Fac Dent, TR-31001 Antakya, Hatay, Turkey.
   [Kirzioglu, Fatma Yesim; Fentoglu, Ozlem] Suleyman Demirel Univ, Dept Periodontol, Fac Dent, Isparta, Turkey.
   [Orhan, Hikmet] Suleyman Demirel Univ, Dept Biostat & Med Informat, Fac Med, Isparta, Turkey.
C3 Hatay Mustafa Kemal University; Suleyman Demirel University; Suleyman
   Demirel University
RP Dogan, ESK (corresponding author), Mustafa Kemal Univ, Dept Periodontol, Fac Dent, TR-31001 Antakya, Hatay, Turkey.
EM esraa_kemer@hotmail.com
RI Fentoğlu, Özlem/GQH-3453-2022; Orhan, Hikmet/A-1089-2016; KIRZIOĞLU,
   Fatma Yeşim/AGQ-2082-2022
OI KALE, BANU/0000-0001-6268-0927
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NR 49
TC 4
Z9 4
U1 0
U2 8
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-3492
EI 1943-3670
J9 J PERIODONTOL
JI J. Periodont.
PD MAR
PY 2018
VL 89
IS 3
BP 331
EP 340
DI 10.1002/JPER.17-0314
PG 10
WC Dentistry, Oral Surgery & Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dentistry, Oral Surgery & Medicine
GA GD5UF
UT WOS:000430571500009
PM 29520769
DA 2025-06-11
ER

PT J
AU Jadon, DR
   Helliwell, PS
AF Jadon, Deepak R.
   Helliwell, Philip S.
TI The role of the multidisciplinary team in the management of psoriatic
   arthritis
SO MUSCULOSKELETAL CARE
LA English
DT Review
DE Crohn's disease; multi-disciplinary; multi-specialty; psoriasis;
   psoriatic arthritis; spondyloarthritis; ulcerative colitis uveitis
ID AXIAL SPONDYLOARTHRITIS
AB Psoriatic arthritis (PsA) has a heterogenous clinical phenotype with manifestations in a number of different organs and systems. Whilst PsA is typified by enthesitis, synovitis and psoriasis (skin and nail); innate and adaptive immune system dysfunction often results in concomitant conditions. These include inflammatory bowel disease, uveitis, metabolic syndrome, metabolic bone disease and mental health issues. All of which have the potential to impact on quality of life, daily function, employment, family life and social activities. Through a collection of clinical vignettes, we describe the importance of multi-disciplinary and multi-speciality involvement in the care of people with PsA.
C1 [Jadon, Deepak R.] Univ Cambridge, Dept Med, Rheumatol Res Unit, Cambridge, England.
   [Helliwell, Philip S.] Univ Leeds, Leeds Inst Rheumat & Musculoskeletal Med, Leeds, England.
   [Jadon, Deepak R.] Univ Cambridge, Dept Med, Rheumatol Res Unit, Cambridge CB2 0QQ, England.
C3 University of Cambridge; University of Leeds; University of Cambridge
RP Jadon, DR (corresponding author), Univ Cambridge, Dept Med, Rheumatol Res Unit, Cambridge CB2 0QQ, England.
EM dj351@cam.ac.uk; p.helliwell@leeds.ac.uk
OI Jadon, Deepak/0000-0003-0600-4566
FU Cambridge Arthritis Research Endeavour (CARE); NIHR Cambridge Biomedical
   Research Centre [BRC-1215-20014]
FX DJ acknowledges that his research is supported by the Cambridge
   Arthritis Research Endeavour (CARE) and the NIHR Cambridge Biomedical
   Research Centre (BRC-1215-20014).
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NR 22
TC 9
Z9 10
U1 0
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1478-2189
EI 1557-0681
J9 MUSCULOSKELET CARE
JI Musculoskelet. Care
PD NOV
PY 2022
VL 20
SU 1
SI SI
BP S32
EP S40
DI 10.1002/msc.1690
PG 9
WC Rheumatology
WE Emerging Sources Citation Index (ESCI)
SC Rheumatology
GA 6A7WF
UT WOS:000880860400007
PM 36356109
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Korniloff, K
   Hakkinen, A
   Kautiainen, H
   Koponen, H
   Peltonen, M
   Mantyselka, P
   Oksa, H
   Kampman, O
   Vanhala, M
AF Korniloff, Katariina
   Hakkinen, Arja
   Kautiainen, Hannu
   Koponen, Hannu
   Peltonen, Markku
   Mantyselka, Pekka
   Oksa, Heikki
   Kampman, Olli
   Vanhala, Mauno
TI Leisure-time physical activity and metabolic syndrome plus depressive
   symptoms in the FIN-D2D survey
SO PREVENTIVE MEDICINE
LA English
DT Article
DE Beck depression Inventory; Depressive symptoms; Metabolic syndrome;
   Physical activity
ID MIDDLE-AGED MEN; BODY-MASS INDEX; CARDIOVASCULAR-DISEASE;
   CARDIORESPIRATORY FITNESS; INSULIN-RESISTANCE; HEALTH BEHAVIORS; FINNISH
   MEN; WOMEN; TRENDS; PREDICTOR
AB Objective To examine the association between leisure-time physical activity (LTPA) and simultaneous presence of metabolic syndrome (MetS) and depressive symptoms (DS) based on a population-based FIN-D2D cross-sectional survey conducted in 2007
   Methods 4500 randomly selected Finnish men and women aged 45-74 years were initially enrolled 2868 (64%) attended a health examination Participants with complete information (n=2778) were grouped into three LTPA categories low moderate and high MetS was based on the National Cholesterol Education Program criteria and DS on the Beck Depression Inventory (>= 10 points)
   Results The prevalence of MetS and DS were 53% and 15% respectively the prevalence of simultaneous MetS and DS was 10% The proportion of subjects with MetS DS and simultaneous presence of MetS and DS increased with decreasing LTPA (p<0 001) On multivariate ordered analysis LTPA was related to education years household income smoking and the presence of MetS only DS only and simultaneous MetS and DS
   Conclusion The prevalence of simultaneous MetS and DS was higher in participants with low LTPA compared with participants with high LTPA. Furthermore LTPA level was associated with socioeconomic status and other health related outcomes outlining the Importance of LTPA as part of the general health promotion (C) 2010 Elsevier Inc All rights reserved
C1 [Korniloff, Katariina; Hakkinen, Arja] Univ Jyvaskyla, Dept Hlth Sci, FI-40014 Jyvaskyla, Finland.
   [Korniloff, Katariina; Hakkinen, Arja] Cent Finland Hlth Care Dist, Dept Phys & Rehabil Med, FI-40620 Jyvaskyla, Finland.
   [Kautiainen, Hannu; Vanhala, Mauno] Cent Finland Hlth Care Dist, Unit Gen Practice, FI-40620 Jyvaskyla, Finland.
   [Kautiainen, Hannu] ORTON Rehabil Unit, FI-00281 Helsinki, Finland.
   [Koponen, Hannu] Univ Eastern Finland, Dept Psychiat, FI-70210 Kuopio, Finland.
   [Koponen, Hannu] Kuopio Univ Hosp, FI-70210 Kuopio, Finland.
   [Peltonen, Markku] Natl Inst Hlth & Welf, FI-00271 Helsinki, Finland.
   [Mantyselka, Pekka; Vanhala, Mauno] Univ Eastern Finland, Dept Primary Healthcare, FI-70211 Kuopio, Finland.
   [Mantyselka, Pekka; Vanhala, Mauno] Kuopio Univ Hosp, Unit Family Practice, FI-70211 Kuopio, Finland.
   [Oksa, Heikki] Tampere Univ Hosp, FI-33521 Tampere, Finland.
   [Kampman, Olli] Univ Tampere, Dept Psychiat, Seinajoki Hosp Dist, FI-33014 Tampere, Finland.
   [Kampman, Olli] Univ Tampere, Sch Med, FI-33014 Tampere, Finland.
C3 University of Jyvaskyla; Central Finland Central Hospital; Central
   Finland Central Hospital; University of Eastern Finland; Kuopio
   University Hospital; University of Eastern Finland; University of
   Eastern Finland Hospital; Finland National Institute for Health &
   Welfare; University of Eastern Finland; Kuopio University Hospital;
   University of Eastern Finland; University of Eastern Finland Hospital;
   Tampere University; Tampere University Hospital; Tampere University;
   Tampere University
RP Korniloff, K (corresponding author), Univ Jyvaskyla, Dept Hlth Sci, PL 35, FI-40014 Jyvaskyla, Finland.
RI Kampman, Olli/AAW-2352-2021; Peltonen, Markku/F-3037-2015
OI Kampman, Olli/0000-0001-6891-2266; Peltonen, Markku/0000-0002-3767-4223;
   Korniloff, Katariina/0000-0002-0753-1483; Hakkinen,
   Arja/0000-0002-5779-1259
FU hospital districts of Pirkanmaa Southern Ostrobothnia North Ostrobothnia
   Central Finland; Finnish National Public Health Institute; Finnish
   Diabetes Association; Ministry of Social Affairs and Health in Finland;
   Finland s Slottery Machine Association; Academy of Finland [129293];
   Commission of the European Communities Directorate C-Public Health
   [2004310]; Central Finland Health Care District; Juho Vainio Foundation;
   Academy of Finland (AKA) [129293] Funding Source: Academy of Finland
   (AKA)
FX FIN-D2D was supported by financing from the hospital districts of
   Pirkanmaa Southern Ostrobothnia North Ostrobothnia Central Finland and
   Northern Savo the Finnish National Public Health Institute the Finnish
   Diabetes Association the Ministry of Social Affairs and Health in
   Finland and Finland s Slottery Machine Association the Academy of
   Finland (grant number 129293) and the Commission of the European
   Communities Directorate C-Public Health (grant agreement number 2004310)
   in cooperation with the FIN-D2D Study Group and the Steering Committe
   Huttunen J Kesaniemi A Kiuru S Niskanen L, Oksa H Pihlajamaki J Puolakka
   J Puska P Saaristo T Vanhala M and Uusitupa M This work was supported by
   research grants from the Central Finland Health Care District and the
   Juho Vainio Foundation
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NR 46
TC 19
Z9 23
U1 0
U2 4
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0091-7435
EI 1096-0260
J9 PREV MED
JI Prev. Med.
PD DEC
PY 2010
VL 51
IS 6
BP 466
EP 470
DI 10.1016/j.ypmed.2010.09.007
PG 5
WC Public, Environmental & Occupational Health; Medicine, General &
   Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; General & Internal Medicine
GA 696LI
UT WOS:000285442500005
PM 20854837
DA 2025-06-11
ER

PT J
AU Walton, EL
AF Walton, Emma Louise
TI The inflammasome: Friend or foe in Chlamydia infection?
SO BIOMEDICAL JOURNAL
LA English
DT Article
DE Chlamydia; Inflammasome; Caspase-1; Depression; Basilar artery
ID CARDIAC SYNDROME-X; HELICOBACTER-PYLORI; DIABETES-MELLITUS;
   TUBERCULOSIS; ASSOCIATION; DEPRESSION; PROTEINS; IMMUNITY
AB In this issue of the Biomedical Journal, we take a look at the still somewhat perplexing role of the inflammasome in Chlamydia infection. We also highlight findings suggesting a link between structural changes to arteries in the brain and the onset of depression. Finally, we learn about some of the implications of co-morbidity between diabetes and infectious diseases.
C1 [Walton, Emma Louise] Biomed Journal, 56 Dronningens Gate, N-7012 Trondheim, Norway.
RP Walton, EL (corresponding author), Biomed Journal, 56 Dronningens Gate, N-7012 Trondheim, Norway.
EM ewalton86@gmail.com
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NR 32
TC 2
Z9 2
U1 0
U2 2
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 2319-4170
EI 2320-2890
J9 BIOMED J
JI Biomed. J.
PD OCT
PY 2016
VL 39
IS 5
BP 299
EP 303
DI 10.1016/j.bj.2016.10.003
PG 5
WC Biochemistry & Molecular Biology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Research & Experimental Medicine
GA EG2QJ
UT WOS:000390888500001
PM 27884375
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Vázquez-Medina, JP
   Popovich, I
   Thorwald, MA
   Viscarra, JA
   Rodriguez, R
   Sonanez-Organis, JG
   Lam, L
   Peti-Peterdi, J
   Nakano, D
   Nishiyama, A
   Ortiz, RM
AF Vazquez-Medina, Jose Pablo
   Popovich, Irina
   Thorwald, Max A.
   Viscarra, Jose A.
   Rodriguez, Ruben
   Sonanez-Organis, Jose G.
   Lam, Lisa
   Peti-Peterdi, Janos
   Nakano, Daisuke
   Nishiyama, Akira
   Ortiz, Rudy M.
TI Angiotensin receptor-mediated oxidative stress is associated with
   impaired cardiac redox signaling and mitochondrial function in
   insulin-resistant rats
SO AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
LA English
DT Article
DE NADPH oxidase; metabolic syndrome; Nrf2
ID DIABETIC CARDIOVASCULAR DISORDERS; INDUCED SUPEROXIDE-PRODUCTION; NADPH
   OXIDASE NOX4; ENDOTHELIAL DYSFUNCTION; METABOLIC SYNDROME; TYPE-1
   RECEPTOR; HEART-FAILURE; CROSS-TALK; IN-VIVO; HYPERTENSION
AB Activation of angiotensin receptor type 1 (AT1) contributes to NADPH oxidase (Nox)-derived oxidative stress during metabolic syndrome. However, the specific role of AT1 in modulating redox signaling, mitochondrial function, and oxidative stress in the heart remains more elusive. To test the hypothesis that AT1 activation increases oxidative stress while impairing redox signaling and mitochondrial function in the heart during diet-induced insulin resistance in obese animals, Otsuka Long Evans Tokushima Fatty (OLETF) rats (n = 8/group) were treated with the AT1 blocker (ARB) olmesartan for 6 wk. Cardiac Nox2 protein expression increased 40% in OLETF compared with age-matched, lean, strain-control Long Evans Tokushima Otsuka (LETO) rats, while mRNA and protein expression of the H2O2-producing Nox4 increased 40-100%. ARB treatment prevented the increase in Nox2 without altering Nox4. ARB treatment also normalized the increased levels of protein and lipid oxidation (nitrotyrosine, 4-hydroxynonenal) and increased the redox-sensitive transcription factor Nrf2 by 30% and the activity of antioxidant enzymes (SOD, catalase, GPx) by 50-70%. Citrate synthase (CS) and succinate dehydrogenase (SDH) activities decreased 60-70%, whereas cardiac succinate levels decreased 35% in OLETF compared with LETO, suggesting that mitochondrial function in the heart is impaired during obesity-induced insulin resistance. ARB treatment normalized CS and SDH activities, as well as succinate levels, while increasing AMPK and normalizing Akt, suggesting that AT1 activation also impairs cellular metabolism in the diabetic heart. These data suggest that the cardiovascular complications associated with metabolic syndrome may result from AT1 receptor-mediated Nox2 activation leading to impaired redox signaling, mitochondrial activity, and dysregulation of cellular metabolism in the heart.
C1 [Vazquez-Medina, Jose Pablo; Popovich, Irina; Thorwald, Max A.; Viscarra, Jose A.; Rodriguez, Ruben; Sonanez-Organis, Jose G.; Ortiz, Rudy M.] Univ Calif Merced, Sch Nat Sci, Dept Mol & Cellular Biol, Merced, CA 95343 USA.
   [Lam, Lisa; Peti-Peterdi, Janos] Univ So Calif, Keck Sch Med, Dept Physiol & Biophys, Los Angeles, CA 90033 USA.
C3 University of California System; University of California Merced;
   University of Southern California
RP Ortiz, RM (corresponding author), Univ Calif Merced, Sch Nat Sci, Dept Mol & Cellular Biol, 5200 North Lake Rd, Merced, CA 95343 USA.
EM rortiz@ucmerced.edu
RI Vazquez-Medina, Jose/AAH-8432-2020; SONANEZ-ORGANIS, JOSE/L-9583-2019;
   NAKANO, DAISUKE/JWP-5663-2024
OI Viscarra, Jose/0000-0003-1273-4098; Rodriguez,
   Ruben/0009-0006-5222-7145; Sonanez-Organis, Jose/0000-0002-8742-3262;
   Vazquez-Medina, Jose Pablo/0000-0003-1014-5214; Thorwald,
   Max/0000-0003-0095-5344; Nishiyama, Akira/0000-0001-5971-820X;
   Rodriguez, Ruben/0000-0001-8174-2556
FU University of California Institute for Mexico; United States (UC MEXUS);
   Mexico's National Council for Science and Technology (CONACYT); American
   Physiological Society; National Institute on Minority Health and Health
   Disparities [T37 MD-001480]; UC MEXUS; CONACYT; National Heart, Lung,
   and Blood Institute [K02 HL-103787, R01 HL-091767]; American Diabetes
   Association [1-11-BS-121]
FX J. P. Vazquez-Medina was supported by The University of California
   Institute for Mexico and The United States (UC MEXUS), and Mexico's
   National Council for Science and Technology (CONACYT). I.P. was
   supported by an American Physiological Society Undergraduate Summer
   Research Fellowship. J. A. Viscarra and R. Rodriguez were supported in
   part by T37 MD-001480 from the National Institute on Minority Health and
   Health Disparities. J. G. Sonanez-Organis was supported by a
   postdoctoral fellowship from UC MEXUS and CONACYT. R. M. Ortiz was
   partially supported by National Heart, Lung, and Blood Institute K02
   HL-103787. Research was funded in parts by grants from American Diabetes
   Association Grant 1-11-BS-121 (J. Peti-Peterdi), National Institute on
   Minority Health and Health Disparities Grant T37 MD-001480, and National
   Heart, Lung, and Blood Institute Grant R01 HL-091767 (R. M. Ortiz).
   Olmesartan was kindly donated by Daiichi-Sankyo (Tokyo, Japan) to A.
   Nishiyama.
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NR 65
TC 49
Z9 59
U1 0
U2 13
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0363-6135
J9 AM J PHYSIOL-HEART C
JI Am. J. Physiol.-Heart Circul. Physiol.
PD AUG
PY 2013
VL 305
IS 4
BP H599
EP H607
DI 10.1152/ajpheart.00101.2013
PG 9
WC Cardiac & Cardiovascular Systems; Physiology; Peripheral Vascular
   Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Physiology
GA 206UQ
UT WOS:000323549500015
PM 23771688
OA Green Published
DA 2025-06-11
ER

PT J
AU Rosado-Pérez, J
   Aguiñiga-Sánchez, I
   Santiago-Osorio, E
   Mendoza-Núñez, VM
AF Rosado-Perez, Juana
   Aguiniga-Sanchez, Itzen
   Santiago-Osorio, Edelmiro
   Manuel Mendoza-Nunez, Victor
TI Effect of Sechium edule var. nigrum spinosum (Chayote) on Oxidative
   Stress and Pro-Inflammatory Markers in Older Adults with Metabolic
   Syndrome: An Exploratory Study
SO ANTIOXIDANTS
LA English
DT Article
DE Sechium edule; chayote; metabolic syndrome; oxidative stress;
   inflammatory markers; older adults
ID FATTY LIVER; NARINGENIN; ACTIVATION; FLAVONOIDS; LIPOGENESIS; PROTECTS;
   OBESITY
AB Metabolic syndrome (MetS) is a risk factor for cognitive deterioration and frailty in older adults. In this regard it has been shown that oxidative stress (OxS) and chronic inflammation are involved in the pathophysiology of these alterations. Harmless antioxidant and anti-inflammatory therapeutic alternatives have been proposed, such as the consumption of Sechium edule (chayote), but the evidence is inconclusive. For this reason, an exploratory study of a single group chosen by convenience sampling, including 12 older adults, with an average age of 71 +/- 6 years (10 women and 2 men) with a diagnosis of MetS according to the National Cholesterol Education Program Adult Treatment Panel III (NCEP/ATP III) criteria. This exploratory study aimed to determine the effect of the consumption of the dried fruit powder supplement of Sechium edule var. nigrum spinosum (500 mg, 3 times per day) for six weeks on the markers of OxS in elderly adults with MetS. All participants' OxS markers were measured before and after treatment. There was a statistically significant decrease in the concentration of lipoperoxides (baseline, 0.289 +/- 0.04 vs. post-treatment, 0.234 +/- 0.06 mol/L, p < 0.05), together with a significant increase in total antioxidant status (baseline, 0.97 +/- 0.18 vs. post-treatment, 1.2 +/- 0.12 mmol/L, p < 0.05). In this sense, the oxidative stress index showed a statistically significant decrease (baseline, 1.7 +/- 0.78 vs. post-treatment, 0.75 +/- 0.87, p < 0.05). A statistically significant decrease in the concentration of TNF- after treatment was also found (baseline, 5.3 +/- 1.4 vs. post-treatment, 3.5 +/- 1.3, p < 0.05).Our findings suggest that the consumption of the dry fruit of Sechium edule has an antioxidant and anti-inflammatory effect in older adults with metabolic syndrome.
C1 [Rosado-Perez, Juana; Manuel Mendoza-Nunez, Victor] Univ Nacl Autonoma Mexico, FES Zaragoza, Res Unit Gerontol, Mexico City 09230, DF, Mexico.
   [Aguiniga-Sanchez, Itzen; Santiago-Osorio, Edelmiro] Univ Nacl Autonoma Mexico, FES Zaragoza, Hematopoiesis & Leukemia Lab, Res Unit Cell Differentiat & Canc, Mexico City 09230, DF, Mexico.
C3 Universidad Nacional Autonoma de Mexico; Universidad Nacional Autonoma
   de Mexico
RP Mendoza-Núñez, VM (corresponding author), Univ Nacl Autonoma Mexico, FES Zaragoza, Res Unit Gerontol, Mexico City 09230, DF, Mexico.
EM juanaropez@yahoo.com.mx; liberitzen@yahoo.com.mx; edelmiro@unam.mx;
   mendovic@unam.mx
RI Mendoza-Núñez, Víctor Manuel/AFL-2465-2022
OI Santiago-Osorio, Edelmiro/0000-0002-4876-0688; Aguiniga-Sanchez,
   Itzen/0000-0003-1692-8287
FU General Directorate of Academic Personnel Affairs, National Autonomous
   University of Mexico (DGAPA); General Directorate of Academic Personnel
   Affairs, National Autonomous University of Mexico (UNAM); Secretariat of
   Science and the Technology and Innovation Project of Mexico City
   (SECITI) [PAPIIT IN218718, SECITI/045/2018]
FX This work was supported by grants from the General Directorate of
   Academic Personnel Affairs, National Autonomous University of Mexico
   (DGAPA and UNAM) and the Secretariat of Science (PAPIIT IN218718), and
   the Technology and Innovation Project of Mexico City (SECITI)
   (SECITI/045/2018).
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NR 59
TC 19
Z9 19
U1 2
U2 8
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD MAY
PY 2019
VL 8
IS 5
AR 146
DI 10.3390/antiox8050146
PG 10
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA IC5PO
UT WOS:000471020500036
PM 31137783
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Hsu, CS
   Liu, TT
   Wen, SH
   Wang, CC
   Yi, CH
   Chen, JH
   Lei, WY
   Orr, WC
   Fabio, P
   Chen, CL
AF Hsu, Ching-Sheng
   Liu, Tso-Tsai
   Wen, Shu-Hui
   Wang, Chia-Chi
   Yi, Chih-Hsun
   Chen, Jiann-Hwa
   Lei, Wei-Yi
   Orr, William C.
   Fabio, Pace
   Chen, Chien-Lin
TI Clinical, metabolic, and psychological characteristics in patients with
   gastroesophageal reflux disease overlap with irritable bowel syndrome
SO EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
LA English
DT Article
DE case-control study; gastroesophageal reflux disease; irritable bowel
   syndrome; metabolic syndrome; Rome III criteria
ID QUALITY-OF-LIFE; NATURAL-HISTORY; SYMPTOMS; GENDER; ESOPHAGITIS;
   PERSPECTIVE; PREVALENCE; VALIDATION; COMMUNITY; BURDEN
AB Objectives Gastroesophageal reflux disease (GERD) and irritable bowel syndrome (IBS) are highly prevalent in the general population, with significant symptom overlap, whereas the interaction between both remains poorly understood. We aim to identify the clinical and psychological factors that contribute toward the overlap of GERD and IBS.
   Patients and methods We carried out a case-control study among 806 GERD and 176 IBS patients from a health check-up cohort (n = 2604). All participants were evaluated using the Reflux Disease Questionnaire score, the Pittsburgh Sleep Quality Index score, the Taiwanese Depression Questionnaire score, and the State-Trait Anxiety Inventory score. Endoscopic findings were classified according to the Los Angeles classification. IBS was diagnosed on the basis of Rome III criteria, and metabolic syndrome was defined by the National Cholesterol Education Program Adult Treatment Panel III definition.
   Results Among the study population, 727 individuals had GERD, 97 individuals had IBS, and 79 individuals had a diagnosis of both GERD and IBS (GERD-I). GERD-I patients had more severe GERD symptoms compared with patients with GERD or IBS alone (P < 0.0001). Moreover, GERD-I patients had more frequent healthcare-seeking behavior, decreased quality of sleep, and higher depression scores than patients with GERD (P < 0.0001) or IBS alone (P < 0.05). In addition, GERD-I patients had lower blood pressure, waist-to-hip ratio, and higher serum high-density lipoprotein levels than those with GERD alone (P< 0.05).
   Conclusion GERD patients overlapping with IBS have different clinical and psychological profiles than those with GERD or IBS alone. Our study suggests that awareness of these symptom presentations will help optimize the treatment of these conditions. Copyright (C) 2015 Wolters Kluwer Health, Inc. All rights reserved.
C1 [Hsu, Ching-Sheng; Wang, Chia-Chi; Chen, Jiann-Hwa] Taipei Tzu Chi Hosp, Div Gastroenterol, Dept Internal Med, Taipei, Taiwan.
   [Hsu, Ching-Sheng; Liu, Tso-Tsai; Yi, Chih-Hsun; Lei, Wei-Yi; Chen, Chien-Lin] Hualien Tzu Chi Hosp, Buddhist Tzu Chi Med Fdn, Dept Internal Med, Div Gastroenterol, Taipei, Taiwan.
   [Liu, Tso-Tsai; Wang, Chia-Chi; Yi, Chih-Hsun; Chen, Jiann-Hwa; Lei, Wei-Yi; Chen, Chien-Lin] Tzu Chi Univ, Coll Med, Sch Med, Hualien, Taiwan.
   [Wen, Shu-Hui] Tzu Chi Univ, Coll Med, Dept Publ Hlth, Hualien, Taiwan.
   [Orr, William C.] Univ Oklahoma, Hlth Sci Ctr, Lynn Inst Healthcare Res, Oklahoma City, OK USA.
   [Fabio, Pace] L Sacco Univ Hosp, Dept Clin Sci, Div Gastroenterol, Milan, Italy.
C3 Buddhist Tzu Chi General Hospital; Tzu Chi University; Tzu Chi
   University; University of Oklahoma System; University of Oklahoma Health
   Sciences Center; University of Milan; Luigi Sacco Hospital
RP Chen, CL (corresponding author), Hualien Tzu Chi Hosp, Buddhist Tzu Chi Med Fdn, Dept Internal Med, Div Gastroenterol, 707,Sec 3,Chung Yang Rd, Hualien 970, Taiwan.
EM harry.clchen@msa.hinet.net
RI Huang, Shu-cheng/KTH-9549-2024; Lei, Wei-Yi/AAW-8292-2020
OI Wen, Shu-Hui/0000-0003-1402-9114
FU Hualien Tzu Chi Hospital; Taipei Tzu Chi Hospital, Buddhist Tzu Chi
   Medical Foundation [TCRD-TPE-103-35, TCRD-TPE-104-31, TCRD-I101-02]
FX This work was supported by grants from the Hualien Tzu Chi Hospital and
   Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation
   (TCRD-TPE-103-35 and TCRD-TPE-104-31 and TCRD-I101-02).
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NR 36
TC 20
Z9 20
U1 0
U2 14
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0954-691X
EI 1473-5687
J9 EUR J GASTROEN HEPAT
JI Eur. J. Gastroenterol. Hepatol.
PD MAY
PY 2015
VL 27
IS 5
BP 516
EP 522
DI 10.1097/MEG.0000000000000334
PG 7
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA CE9KK
UT WOS:000352162600006
PM 25822860
DA 2025-06-11
ER

PT J
AU Armeni, A
   Armeni, E
   Augoulea, A
   Stergiotis, S
   Kaparos, G
   Alexandrou, A
   Eleftheriadis, M
   Georgopoulos, N
   Vlahos, N
   Lambrinoudaki, I
AF Armeni, Anastasia
   Armeni, Eleni
   Augoulea, Areti
   Stergiotis, Stefanos
   Kaparos, George
   Alexandrou, Andreas
   Eleftheriadis, Makarios
   Georgopoulos, Neoklis
   Vlahos, Nicolaos
   Lambrinoudaki, Irene
TI Climacteric symptoms, age, and sense of coherence are associated with
   sexual function scores in women after menopause
SO JOURNAL OF SEXUAL MEDICINE
LA English
DT Article
DE sexuality; menopause; climacteric symptoms; sense of coherence
ID ANTONOVSKYS SENSE; HEALTH; DYSFUNCTION; PREVALENCE; DESIRE; SCALE; RISK;
   TESTOSTERONE; VALIDATION; ANXIETY
AB BackgroundPostmenopausal sexual function presupposes the integration of hormonal, neural, and vascular interactions and is subject to optimal crosstalk among psychological, interpersonal, cultural, and environmental factors. Sense of coherence (SOC) reflects a person's ability to cope with stressors and may influence the occurrence of menopausal symptoms and sexual dysfunction.AimTo investigate the association of severity of climacteric symptoms, cardiometabolic risk factors, and SOC with sexual function in postmenopausal women.MethodsOverall 281 sexually active postmenopausal women without significant psychopathology or cardiovascular disease attending the Menopause Unit of Aretaieion Hospital were evaluated by the Female Sexual Function Index (FSFI), Greene Climacteric Scale, Beck Depression Scale, and Sense of Coherence Scale. Hormonal and biochemical parameters and cardiometabolic risk factors were evaluated. FSFI scores OutcomesTotal and subdomain scores of sexual response were determined.ResultsPathologic FSFI scores were found in 79.7% of the sample. Linear models of multivariable regression analysis showed that FSFI scores were associated with (1) Beck scores (b = -0.200; 95% CI, -0.472 to -0.073, P = .001), vasomotor symptom severity (b = -0.324; 95% CI, -0.985 to 0.051; P < .001), and age and (2) SOC (b = 0.150, 95% CI, 0.036-0.331; P = .008), vasomotor symptom severity (b = -0.361; 95% CI, -0.743 to 0.245; P < .001), and age. Both models were adjusted for menopausal age, diabetes mellitus, hypertension, type of menopause, and menopausal hormone therapy intake. SOC was associated with Beck depression scores (& beta; = -0.487, P < .001; Greene Climacteric Scale total scores, & beta; = -0.199, P < .001). FSFI score 26.5 was associated with SOC (odds ratio, 0.982; 95% CI, 0.563 to 1.947; P = .006) and moderate to severe vasomotor symptom severity (odds ratio, 2.476; 95% CI, 1.478 to 3.120; P = .009) independent of age, diabetes mellitus, hypertension, menopausal hormone therapy intake, type of menopause, or Beck depression classification.Clinical ImplicationsThe results indicate the importance of psychometric assessment of postmenopausal women when presenting with scores of low sexual function. The severity of vasomotor symptoms should also be addressed in any case.Strengths and LimitationsThis is the first study investigating the relationship between SOC and sexuality in menopause in a carefully selected homogenous population. Limitations included the cross-sectional design and the fact that sexual distress was not assessed.ConclusionsPathologic FSFI scores were highly prevalent in this sample of postmenopausal women. FSFI is associated positively with age and severity of vasomotor symptoms and negatively with SOC.
C1 [Armeni, Anastasia; Armeni, Eleni; Augoulea, Areti; Stergiotis, Stefanos; Alexandrou, Andreas; Eleftheriadis, Makarios; Vlahos, Nicolaos; Lambrinoudaki, Irene] Natl & Kapodistrian Univ Athens, Aretaie Hosp, GR-11528 Athens, Greece.
   [Armeni, Anastasia; Georgopoulos, Neoklis] Univ Patras, Univ Hosp, Dept Obstet & Gynecol, Div Reprod Endocrinol,Med Sch, GR-26504 Patras, Greece.
   [Kaparos, George] Natl & Kapodistrian Univ Athens, Aretaie Hosp, Biochem Lab, GR-11528 Athens, Greece.
   [Lambrinoudaki, Irene] Natl & Kapodistrian Univ Athens, Aretaie Hosp, Dept Obstet & Gynaecol 2, Athens, Greece.
C3 National & Kapodistrian University of Athens; University of Patras;
   National & Kapodistrian University of Athens; National & Kapodistrian
   University of Athens
RP Lambrinoudaki, I (corresponding author), Natl & Kapodistrian Univ Athens, Aretaie Hosp, Dept Obstet & Gynaecol 2, Athens, Greece.
EM armanastasia@yahoo.gr; elenaarmeni@hotmail.com; aretiaugoulea@yahoo.gr;
   stef_ster@hotmail.com; captenkap@yahoo.gr; alexandrouandrea@hotmail.com;
   makarios@hotmail.co.uk; neoklisgeorgo@gmail.com; nfvlahos@gmail.com;
   ilambrinoudaki@med.uoa.gr
RI Armeni, Eleni/ABW-4946-2022
OI Armeni, Eleni/0000-0003-3310-1521
FU European Union (European Social Fund) through the operational program
   Human Resources Development, Education and Life-long Learning
   [MIS-5033021]
FX This research is cofinanced by Greece and the European Union (European
   Social Fund) through the operational program Human Resources
   Development, Education and Life-long Learning in the context of the
   project Reinforcement of Postdoctoral Researchers-Second Cycle
   (MIS-5033021), implemented by the State Scholarships Foundation.& nbsp;
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NR 69
TC 7
Z9 7
U1 2
U2 12
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1743-6095
EI 1743-6109
J9 J SEX MED
JI J. Sex. Med.
PD FEB 27
PY 2023
VL 20
IS 3
BP 313
EP 323
DI 10.1093/jsxmed/qdac031
PG 11
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA L2NX9
UT WOS:001021689200010
PM 36763958
DA 2025-06-11
ER

PT J
AU Lonardo, A
AF Lonardo, Amedeo
TI Renaming NAFLD to MAFLD: Could the LDE System Assist in This Transition?
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Review
DE classification; endocrine; hepatocellular carcinoma (HCC); LDE system;
   NAFLD; MAFLD; metabolic syndrome; psycho-depression; virus-associated
   fatty liver disease (VAFLD)
ID NONALCOHOLIC FATTY LIVER; METABOLIC SYNDROME; INSULIN-RESISTANCE;
   RISK-FACTORS; DISEASE; STEATOHEPATITIS; NASH; MANAGEMENT; STEATOSIS;
   HEALTH
AB Our understanding of fatty liver syndromes and their relationship with the metabolic syndrome has improved over recent decades and, paralleling this, we are now at the dawn of the NAFLD (nonalcoholic fatty liver disease) to MAFLD (metabolic-associated fatty liver disease) transition. The pitfalls of NAFLD diagnosis, together with disappointing results in therapeutic trials, and the inconsistencies and risks inherent in a "negative" definition (such as "nonalcoholic") as opposed to a "positive" one (i.e., "metabolic") are predicted to facilitate the proposed renaming of NAFLD to MAFLD. However, a premature change of terminology would not necessarily address major unmet needs in this area, and may even become counterproductive. As an aid to selecting more homogeneous cohorts of patients, I propose the LDE (Liver, Determinants, Extra-hepatic) classification system which, in principle, may help to assess the natural course of disease as well as the efficacy of novel drugs in patients with NAFLD/MAFLD.
C1 [Lonardo, Amedeo] Azienda Osped Univ Modena, Dept Internal Med, I-4110 Modena, Italy.
RP Lonardo, A (corresponding author), Azienda Osped Univ Modena, Dept Internal Med, I-4110 Modena, Italy.
EM lonardo.amedeo@aou.mo.it
RI Lonardo, Amedeo/I-5911-2019
OI Lonardo, Amedeo/0000-0001-9886-0698
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NR 101
TC 32
Z9 32
U1 1
U2 4
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD FEB
PY 2021
VL 10
IS 3
AR 492
DI 10.3390/jcm10030492
PG 13
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA QD3HY
UT WOS:000615415000001
PM 33572544
OA Green Published
DA 2025-06-11
ER

PT J
AU O'Connor, N
   Hunt, GE
   O'Hara-Aarons, M
   Hall, A
   Snars, J
   Storm, V
   Lambert, T
AF O'Connor, Nick
   Hunt, Glenn E.
   O'Hara-Aarons, Maureen
   Hall, Allan
   Snars, Jeff
   Storm, Victor
   Lambert, Tim
TI The Sydney Mental Health Client Mortality Audit: what does it tell us
   and what are we to do?
SO AUSTRALASIAN PSYCHIATRY
LA English
DT Article
DE antipsychotics; heart disease; metabolic syndrome; mortality; obesity;
   premature death; quality of life; schizophrenia; suicide
ID CARDIOVASCULAR-DISEASE; PEOPLE; SCHIZOPHRENIA; PSYCHOSIS; ILLNESS; RISK
AB Objectives: To examine the characteristics of those mental health clients of an Australian metropolitan health service who died during a 6 year period, 2005 - 2010.
   Methods: The medical records, and where available, coronial post-mortem examinations were audited for 109 people with schizophrenia who died while they were clients of the mental health service.
   Results: The mean age of death for men was 45 years and for women, 47 years, compared to the general population's male and female life expectancy of 79 and 84 years, respectively. About one-half of the deaths were due to suicide (n = 55), followed by natural causes (n = 42; 39%), undetermined causes (n = 7), and accidents or acts of violence (n = 5). Smoking rates, diagnosed diabetes and hypertension were higher in the group that died from natural causes. Morbid obesity (body mass index (BMI) > 35 kg/m(2)) rates were higher in the group that died of natural causes (38%), compared with the suicide group (5%).
   Conclusions: While suicide accounts for the majority of those dying prematurely in this study cohort, it appears that for those who survive the risk of suicide in the earlier period of a chronic psychotic illness, there is yet another threat to life expectancy: death from preventable cardiorespiratory disorders, due to a poor lifestyle and social deprivation.
C1 [O'Connor, Nick] North Shore Ryde Mental Hlth Serv, St Leonards, NSW 2065, Australia.
   [O'Connor, Nick; Hunt, Glenn E.] Univ Sydney, Discipline Psychiat, Sydney, NSW 2006, Australia.
   [Hunt, Glenn E.; O'Hara-Aarons, Maureen; Hall, Allan; Snars, Jeff; Storm, Victor] Sydney Local Hlth Dist, Concord Ctr Mental Hlth, Concord, NSW, Australia.
   [Storm, Victor] Univ Western Sydney, Sydney, NSW, Australia.
   [Lambert, Tim] Concord Clin Sch, Concord, NSW, Australia.
   [Lambert, Tim] Univ Sydney, Brain & Mind Res Inst, Sydney, NSW 2006, Australia.
C3 University of Sydney; Sydney Local Health District; Western Sydney
   University; University of Sydney
RP O'Connor, N (corresponding author), North Shore Ryde Mental Hlth Serv, 2C Herbert St, St Leonards, NSW 2065, Australia.
EM Nick.oconnor@health.nsw.gov.au
RI Hunt, Glenn/G-5934-2012
OI Hunt, glenn/0000-0002-8088-9406
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NR 24
TC 6
Z9 6
U1 0
U2 11
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1039-8562
EI 1440-1665
J9 AUSTRALAS PSYCHIATRY
JI Australas. Psychiatry
PD APR
PY 2014
VL 22
IS 2
BP 154
EP 159
DI 10.1177/1039856213519690
PG 6
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA AE5KP
UT WOS:000334028000010
PM 24449531
DA 2025-06-11
ER

PT J
AU Stanhope, KK
   Stallworth, T
   Forest, AD
   Vuncannon, D
   Juarez, G
   Boulet, SL
   Geary, F
   Dunlop, AL
   Blake, SC
   Green, VL
   Jamieson, DJ
AF Stanhope, Kaitlyn K.
   Stallworth, Tae
   Forest, Alexandra D.
   Vuncannon, Danielle
   Juarez, Gabriela
   Boulet, Sheree L.
   Geary, Franklyn
   Dunlop, Anne L.
   Blake, Sarah C.
   Green, Victoria L.
   Jamieson, Denise J.
TI Planning for the forgotten fourth trimester of pregnancy: A parallel
   group randomized control trial to test a postpartum planning
   intervention vs. standard prenatal care
SO CONTEMPORARY CLINICAL TRIALS
LA English
DT Article
DE Pregnancy; Postpartum period; Pre-eclampsia; Patient navigation; Social
   determinants of health; Postnatal care
ID HEALTH; WOMEN
AB Background: Black and brown birthing people experience persistent disparities in adverse maternal health outcomes, partially due to inadequate perinatal care. The goal of this study is to design and evaluate a patientcentered intervention for obstetric patients with one or more cardiometabolic risk factors for severe maternal morbidity [gestational diabetes, diabetes mellitus, hypertensive disorders of pregnancy (chronic hypertension, preeclampsia, eclampsia, or gestational hypertension), or preconception obesity (BMI > 30)] to promote postpartum visit attendance. Methods: To address identified unmet needs for postpartum support and barriers to postpartum care, we developed 20 thematic postpartum planning modules, each with corresponding patient educational materials, community resources, care coordination protocols, and clinician support tools (decision aids, electronic medical record prompts and fields). During prenatal care encounters, a research coordinator delivers the educational content (in English or Spanish), facilitates the participant 's planning and shared decision-making, provides the participant with resources, and documents decisions in the electronic medical record. We will randomize 320 eligible patients with a 1:1 ratio to the intervention or standard prenatal care and evaluate the impact on postpartum visit attendance at 4 -12 weeks and secondary outcomes (postpartum mental health, perceived future maternal and cardiometabolic risk, contraceptive use, primary care use, readmission, and patient satisfaction with care). Discussion: Through engagement with patients and community stakeholders, we developed a guideline-based, locally tailored intervention to address drivers of engagement with postpartum care for high-risk obstetric patients. If demonstrated to be effective, the educational materials and electronic medical record based-tool can be adapted to other settings.
C1 [Stanhope, Kaitlyn K.; Stallworth, Tae; Forest, Alexandra D.; Vuncannon, Danielle; Juarez, Gabriela; Boulet, Sheree L.; Dunlop, Anne L.; Green, Victoria L.; Jamieson, Denise J.] Emory Univ, Dept Gynecol & Obstet, Sch Med, Atlanta, GA 30322 USA.
   [Stanhope, Kaitlyn K.] Emory Univ, Rollins Sch Publ Hlth, Dept Epidemiol, 1518 Clifton Rd NE Off 3023, Atlanta, GA USA.
   [Geary, Franklyn] Morehouse Sch Med, Dept Obstet & Gynecol, Atlanta, GA USA.
   [Blake, Sarah C.] Emory Univ, Rollins Sch Publ Hlth, Dept Hlth Policy & Management, Atlanta, GA USA.
   [Jamieson, Denise J.] Univ Iowa, Sch Med, Johnson Cty, LA USA.
C3 Emory University; Emory University; Rollins School Public Health;
   Morehouse School of Medicine; Emory University; Rollins School Public
   Health
RP Stanhope, KK (corresponding author), Emory Univ, Dept Gynecol & Obstet, Sch Med, Atlanta, GA 30322 USA.
EM kaitlyn.keirsey.stanhope@emory.edu
RI Boulet, Sheree/IWU-4605-2023; Kerisey, Kaitlyn/ABE-5436-2021
FX This study is funded by the National Institute of Minority Health and
   Health Disparities (R01MD016031) and registered under clinicaltrials.
   gov (NCT05430815) . It received ethical approval from the Emory Uni-
   versity Institutional Review Board (00001427) . All participating in-
   dividuals completed informed consent prior to participation in the
   study. The NIMHD has no role in the conduct, analysis, or interpretation
   of results. We have no competing interests to declare.
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NR 52
TC 0
Z9 0
U1 2
U2 2
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1551-7144
EI 1559-2030
J9 CONTEMP CLIN TRIALS
JI Contemp. Clin. Trials
PD AUG
PY 2024
VL 143
AR 107586
DI 10.1016/j.cct.2024.107586
EA JUN 2024
PG 12
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA XB7T0
UT WOS:001259295300001
PM 38838985
DA 2025-06-11
ER

PT J
AU Pawelczyk, T
   Grancow, M
   Kotlicka-Antczak, M
   Trafalska, E
   Gebski, P
   Szemraj, J
   Zurner, N
   Pawelczyk, A
AF Pawelczyk, Tomasz
   Grancow, Marta
   Kotlicka-Antczak, Magdalena
   Trafalska, Elzbieta
   Gebski, Piotr
   Szemraj, Janusz
   Zurner, Natalia
   Pawelczyk, Agnieszka
TI Omega-3 fatty acids in first-episode schizophrenia - a randomized
   controlled study of efficacy and relapse prevention (OFFER): rationale,
   design, and methods
SO BMC PSYCHIATRY
LA English
DT Article
DE Omega-3 fatty acids; Eicosapentaenoic acid; Docosahexaenoic acid;
   Schizophrenia first episode; Relapse; Prevention; Randomized controlled
   trial
ID PLACEBO-CONTROLLED-TRIAL; POLYUNSATURATED FATTY-ACIDS;
   ETHYL-EICOSAPENTAENOIC ACID; CYTOSOLIC PHOSPHOLIPASE-A2 GENE; CALGARY
   DEPRESSION SCALE; NEGATIVE SYNDROME SCALE; RATING-SCALE; DOCOSAHEXAENOIC
   ACID; OMEGA-3 DEFICIENCY; MENTAL-HEALTH
AB Background: Polyunsaturated fatty acid (PUFA) metabolism abnormalities have been long implicated in the etiology of schizophrenia. Although several randomized clinical trials have been carried out to assess the efficacy of omega-3 PUFA as add-on therapy in reducing psychopathology in populations of chronic patients with schizophrenia, only a few concern first-episode schizophrenia. The majority of these studies used a 12-week intervention based on ethyl-eicosapentaenoic acid (ethyl-EPA), however, with conflicting results. An intervention based on docosahexaenoic acid plus EPA has not been used in first-episode schizophrenia studies so far. No add-on supplementation studies have been carried out in medicated first-episode schizophrenia patients to assess the efficacy of omega-3 PUFA in preventing relapses.
   Methods: A randomized placebo-controlled one-center trial will be used to compare the efficacy of 26-week intervention, composed of either 1320 mg/day of EPA and 880 mg/day of DHA, or olive oil placebo with regard to symptom severity and relapse rate in first-episode schizophrenia patients. Eighty-two patients (aged 16-35) will be recruited for the study. Eligible patients will be randomly allocated to one of two intervention arms: an active arm or a placebo arm (olive oil). The primary outcome measure of the clinical evaluation is schizophrenia symptom severity measured by the Positive and Negative Syndrome Scale (PANSS). Other outcomes include depressive symptoms, patient functioning and the level of insight. Correlates of change measured during the study will include structural brain changes, oxidative stress and defense, as well as neuroplasticity indicators. Metabolic syndrome components will also be assessed throughout the study.
   Discussion: By comparing 26-week administration of EPA + DHA or (placebo) olive oil as add-on therapy in reducing symptom severity and one-year relapse rate in patients with first episode schizophrenia, it is intended to provide new insights into the efficacy of omega-3 PUFA and correlates of change, and contribute to the improvement of mental health care for individuals suffering from schizophrenia.
C1 [Pawelczyk, Tomasz; Kotlicka-Antczak, Magdalena; Pawelczyk, Agnieszka] Med Univ Lodz, Dept Affect & Psychot Disorders, PL-92216 Lodz, Poland.
   [Grancow, Marta] Med Univ Lodz, Cent Teaching Hosp, PL-92213 Lodz, Poland.
   [Trafalska, Elzbieta] Med Univ Lodz, Dept Nutr Hyg & Epidemiol, PL-90251 Lodz, Poland.
   [Gebski, Piotr] Scanlab Med Diagnost, PL-90338 Lodz, Poland.
   [Szemraj, Janusz] Med Univ Lodz, Dept Med Biochem, PL-92216 Lodz, Poland.
   [Zurner, Natalia] Med Univ Lodz, Dept Affect & Psychot Disorders, Clin Psychol Resident, PL-92216 Lodz, Poland.
C3 Medical University Lodz; Medical University Lodz; Medical University
   Lodz; Medical University Lodz; Medical University Lodz
RP Pawelczyk, T (corresponding author), Med Univ Lodz, Dept Affect & Psychot Disorders, Ul Czechoslowacka 8-10, PL-92216 Lodz, Poland.
EM tomasz.pawelczyk@umed.lodz.pl
RI Pawełczyk, Agnieszka/N-9039-2019; Pawełczyk, Tomasz/S-9266-2016;
   Pawelczyk, Agnieszka/S-9524-2016
OI Trafalska, Elzbieta/0000-0002-1937-0090; Kotlicka-Antczak,
   Magdalena/0000-0001-5755-6198; Pawelczyk, Agnieszka/0000-0003-1900-0214
FU Polish Science National Center [N N402 243435]
FX This paper was supported by grant no. N N402 243435 obtained from the
   Polish Science National Center. We would like to express our gratitude
   to psychiatrists practicing in Lodz and the region for referring
   eligible patients to Department of Affective and Psychotic Disorders
   Medical University of Lodz in order to enroll them in the study. The
   authors would like to express their special thanks to Prof. Jolanta
   Rabe-Jablonska MD, PhD the former head of the department who was deeply
   involved in study preparation, and who unfortunately died in May 2014.
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NR 80
TC 37
Z9 39
U1 0
U2 18
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-244X
J9 BMC PSYCHIATRY
JI BMC Psychiatry
PD MAY 2
PY 2015
VL 15
AR 97
DI 10.1186/s12888-015-0473-2
PG 13
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychiatry
GA CK1NT
UT WOS:000355974700001
PM 25934131
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Koponen, H
   Jokelainen, J
   Keinänen-Kiukaanniemi, S
   Vanhala, M
AF Koponen, Hannu
   Jokelainen, Jari
   Keinanen-Kiukaanniemi, Sirkka
   Vanhala, Mauno
TI Depressive symptoms and 10-year risk for cardiovascular morbidity and
   mortality
SO WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
LA English
DT Article
DE Beck Depression Inventory; cardiovascular event; Framingham risk
   function; mortality; SCORE risk function
ID CORONARY-HEART-DISEASE; METABOLIC SYNDROME; INSULIN-RESISTANCE;
   INFLAMMATION; INVENTORY; MEN; ASSOCIATION; POPULATION; PREDICTION;
   IMPACT
AB Objectives. Depression is associated with increased physical morbidity and overall mortality. As less is known about how much depression increases the 10-year risk for fatal and nonfatal cardiovascular (CV) events, we evaluated the cross-sectional risk with two well-characterized risk functions measuring CV mortality and total CV event risk. Methods. The prevalence of increased depressive symptoms was measured with the Beck Depression Inventory (BDI), and the SCORE and Framingham risk functions were calculated in a middle-aged population-based sample (N = 923). For metabolic syndrome (MetS), the modified National Cholesterol Education Program - Adult Treatment Panel III criteria were employed. Results. Depressive symptoms were associated with increased CV mortality and morbidity risk in men: OR for SCORE 2.9; 95% CI 1.4-5.7 and OR for Framingham function 2.2 (95% CI 1.1-4.2). In women, the corresponding figures were 1.4 (95% CI 0.3-6.9) and 1.3 (95% CI 0.7-2.6). The BDI scores showed significant correlations with SCORE (r = 0.18 for men, P < 0.001; and r = 0.14 for women, P = 0.002), and Framingham function (for men r = 0.16, P < 0.001; and for women r = 0.13, P = 0.005). Conclusions. Our results suggest that screening and effective treatment of depression are important in the primary and secondary prevention of cardiovascular events, especially in males.
C1 [Koponen, Hannu] Kuopio Univ Hosp, Dept Psychiat, FIN-70211 Kuopio, Finland.
   [Jokelainen, Jari; Keinanen-Kiukaanniemi, Sirkka] Univ Oulu, Inst Hlth Sci, Oulu, Finland.
   [Jokelainen, Jari; Keinanen-Kiukaanniemi, Sirkka] Oulu Univ Hosp, Unit Gen Practice, Oulu, Finland.
   [Vanhala, Mauno] Cent Hosp Middle Finland, Unit Family Practice, Jyvaskyla, Finland.
   [Vanhala, Mauno] Univ Eastern Finland, Dept Family Med, Sch Publ Hlth & Clin Nutr, FIN-70211 Kuopio, Finland.
C3 Kuopio University Hospital; University of Oulu; University of Oulu;
   Central Finland Central Hospital; University of Eastern Finland
RP Koponen, H (corresponding author), Kuopio Univ Hosp, Dept Psychiat, POB 1777, FIN-70211 Kuopio, Finland.
EM hannujuhani.koponen@uku.fi
OI Jokelainen, Jari/0000-0003-4629-0560
FU Central Finland Hospital District; Academy of Finland [113 760]
FX This work was supported by a grant from the Central Finland Hospital
   District (MV), and grant number 113 760 from the Academy of Finland
   (HK). The authors would also like to acknowledge the women and men from
   the Pieksanmaki area who kindly participated.
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NR 39
TC 43
Z9 45
U1 0
U2 1
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1562-2975
EI 1814-1412
J9 WORLD J BIOL PSYCHIA
JI World J. Biol. Psychiatry
PD SEP
PY 2010
VL 11
IS 6
BP 834
EP 839
DI 10.3109/15622975.2010.486842
PG 6
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 654SN
UT WOS:000282190000010
PM 20632843
DA 2025-06-11
ER

PT J
AU Cao, K
   Xu, J
   Zou, X
   Li, Y
   Chen, C
   Zheng, AD
   Li, H
   Li, H
   Szeto, IMY
   Shi, YJ
   Long, JG
   Liu, JK
   Feng, ZH
AF Cao, Ke
   Xu, Jie
   Zou, Xuan
   Li, Yuan
   Chen, Cong
   Zheng, Adi
   Li, Hao
   Li, Hua
   Szeto, Ignatius Man-Yau
   Shi, Yujie
   Long, Jiangang
   Liu, Jiankang
   Feng, Zhihui
TI Hydroxytyrosol prevents diet-induced metabolic syndrome and attenuates
   mitochondrial abnormalities in obese mice
SO FREE RADICAL BIOLOGY AND MEDICINE
LA English
DT Article
DE Oxidative stress; Mitochondrial abnormalities; Insulin resistance;
   Hydroxytyrosol; Apoptosis; Free radicals
ID INCREASED OXIDATIVE STRESS; PIGMENT EPITHELIAL-CELLS; FATTY
   LIVER-DISEASE; OLIVE LEAF EXTRACT; ANTIOXIDANT CAPACITY;
   INSULIN-RESISTANCE; HEPATIC STEATOSIS; SKELETAL-MUSCLE; OIL; DYSFUNCTION
AB A Mediterranean diet rich in olive oil has profound influence on health outcomes including metabolic syndrome. However, the active compound and detailed mechanisms still remain unclear. Hydroxytyrosol (HT), a major polyphenolic compound in virgin olive oil, has received increased attention for its anti-oxidative activity and regulation of mitochondrial function. Here, we investigated whether HT is the active compound in olive oil exerting a protective effect against metabolic syndrome. In this study, we show that HT could prevent high-fat-diet (HFD)-induced obesity, hyperglycemia, hyperlipidemia, and insulin resistance in C57BL/6 J mice after 17 weeks supplementation. Within liver and skeletal muscle tissues, HT could decrease HFD-induced lipid deposits through inhibition of the SREBP-1c/FAS pathway, ameliorate HFD-induced oxidative stress by enhancing antioxidant enzyme activities, normalize expression of mitochondrial complex subunits and mitochondrial fission marker Drp1, and eventually inhibit apoptosis activation. Moreover, in muscle tissue, the levels of mitochondrial carbonyl protein were decreased and mitochondrial complex activities were significantly improved by HT supplementation. In db/db mice, HT significantly decreased fasting glucose, similar to metformin. Notably, HT decreased serum lipid, at which metformin failed. Also, HT was more effective at decreasing the oxidation levels of lipids and proteins in both liver and muscle tissue. Similar to the results in the HFD model, HT decreased muscle mitochondrial carbonyl protein levels and improved mitochondrial complex activities in db/db mice. Our study links the olive oil component HT to diabetes and metabolic disease through changes that are not limited to decreases in oxidative stress, suggesting a potential pharmaceutical or clinical use of HT in metabolic syndrome treatment. (C) 2013 Elsevier Inc. All rights reserved.
C1 [Cao, Ke; Xu, Jie; Li, Yuan; Chen, Cong; Zheng, Adi; Li, Hao; Li, Hua; Szeto, Ignatius Man-Yau; Shi, Yujie; Long, Jiangang; Liu, Jiankang; Feng, Zhihui] Xi An Jiao Tong Univ, Ctr Mitochondrial Biol & Med, Xian 710049, Peoples R China.
   [Cao, Ke; Xu, Jie; Li, Yuan; Chen, Cong; Zheng, Adi; Li, Hao; Li, Hua; Szeto, Ignatius Man-Yau; Shi, Yujie; Long, Jiangang; Liu, Jiankang; Feng, Zhihui] Xi An Jiao Tong Univ, Key Lab Biomed Informat Engn, Minist Educ, Sch Life Sci & Technol, Xian 710049, Peoples R China.
   [Cao, Ke; Xu, Jie; Zou, Xuan; Li, Yuan; Chen, Cong; Zheng, Adi; Li, Hao; Li, Hua; Szeto, Ignatius Man-Yau; Shi, Yujie; Long, Jiangang; Liu, Jiankang; Feng, Zhihui] Xi An Jiao Tong Univ, Frontier Inst Sci & Technol, Xian 710049, Peoples R China.
   [Zou, Xuan] Xi An Jiao Tong Univ, Ctr Translat Med, Key Lab Biomed Informat Engn, Minist Educ,Sch Life Sci & Technol, Xian 710049, Peoples R China.
C3 Xi'an Jiaotong University; Xi'an Jiaotong University; Ministry of
   Education - China; Xi'an Jiaotong University; Xi'an Jiaotong University;
   Ministry of Education - China
RP Liu, JK (corresponding author), Xi An Jiao Tong Univ, Ctr Mitochondrial Biol & Med, Xian 710049, Peoples R China.
EM j.liu@mail.xjtu.edu.cn; zhfeng@mail.xjtu.edu.cn
RI Zou, Xuan/A-6452-2015; Xu, Jie/MNP-4744-2025; Liu, Jiankang/A-1610-2011;
   Long, Jiangang/A-7835-2015; Li, Hao/K-7001-2017; Shi,
   Yujie/GZA-9732-2022; Feng, Zhihui/E-7408-2011
OI Feng, Zhihui/0000-0002-2448-6565; Jiangang, Long/0000-0001-8074-957X;
   Li, Hao/0000-0001-5677-3377
FU National Natural Science Foundation of China [81201023, 31370844]; 973
   Program [2014CB548200]; 985 Project of Xi'an Jiaotong University; 211
   Project of Xi'an Jiaotong University
FX This work was supported by the National Natural Science Foundation of
   China (Nos. 81201023, 31370844), the 973 Program (No. 2014CB548200), and
   the 985 and 211 Projects of Xi'an Jiaotong University.
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NR 50
TC 164
Z9 171
U1 3
U2 53
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0891-5849
EI 1873-4596
J9 FREE RADICAL BIO MED
JI Free Radic. Biol. Med.
PD FEB
PY 2014
VL 67
BP 396
EP 407
DI 10.1016/j.freeradbiomed.2013.11.029
PG 12
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA AB5UM
UT WOS:000331854200037
PM 24316371
DA 2025-06-11
ER

PT J
AU Vidé J
   Bonafos, B
   Fouret, G
   Casas, F
   Jover, B
   Jouy, N
   Feillet-Coudray, C
   Gaillet, S
   Coudray, C
AF Vide, Joris
   Bonafos, Beatrice
   Fouret, Gilles
   Casas, Francois
   Jover, Bernard
   Jouy, Nicolas
   Feillet-Coudray, Christine
   Gaillet, Sylvie
   Coudray, Charles
TI Effect of spirulina and silicon-enriched spirulina on metabolic syndrome
   features, oxidative stress and mitochondrial activity in Zucker fatty
   rats
SO JOURNAL OF FOOD BIOCHEMISTRY
LA English
DT Article
DE mitochondrial activity; obesity disorders; oxidative stress; silicon;
   spirulina; Zucker rat
ID SPECTROPHOTOMETRIC ASSAY; RESPIRATORY-CHAIN; DIETARY SILICON; BONE
   STATUS; PLATENSIS; LIVER; SUPPLEMENTATION; OBESE; GLUTATHIONE;
   PHYCOCYANIN
AB The use of Spirulina platensis (Sp) as a functional food was suggested decades ago. Biological incorporation of Silicon (Si) into Sp increases its bioavailability for potential food supplement applications. This work aimed at determining the effects of Sp and Si-enriched Sp (Sp+Si) on metabolic syndrome features in Zucker fatty rats. Thirty Zucker fatty rats were divided into three groups and supplemented with placebo or Sp or Sp+Si croquettes for 12 weeks. Food consumption, glucose intolerance, hepatic steatosis, and mitochondrial and oxidative stress were determined. Zucker fatty rats exhibited several hepatic metabolic alterations as well as mitochondrial and oxidative stress perturbations. The intake of Sp increased plasma TG levels and decreased the hepatic NADPH oxidase activity and ameliorated transitorily the glucose intolerance. However, Si-spirulina does not appear to have more beneficial effects than spirulina alone. Other experiments with different species of rats/mice, different diets, or durations of diet intake should be undertaken to confirm or infirm these results. Practical applications Glucose intolerance and hepatic steatosis, two major components of metabolic syndrome, are increasing and becomes a major public health issue. Use of Spirulina platensis (Sp) as a functional food was suggested as a protein-dense food source. Bioavailable silicon (Si) may be an essential nutrient for higher animals, including humans. Sp but not Sp+Si decreased liver NADPH oxidase activity and improved transitorily glucose tolerance. This is the first study where Sp and Sp+Si effect on glucose intolerance is reported in Zucker rat. Other experiments should be undertaken to confirm or infirm invalidate the beneficial effects of Sp+Si supplement in the metabolic syndrome features.
C1 [Vide, Joris; Bonafos, Beatrice; Fouret, Gilles; Casas, Francois; Feillet-Coudray, Christine; Gaillet, Sylvie; Coudray, Charles] Univ Montpellier, INRA, DMEM, Montpellier, France.
   [Jover, Bernard] Univ Montpellier, CNRS, INSERM, PhyMedExp, Montpellier, France.
   [Jouy, Nicolas] Phycobiotech SAS, Montpellier, France.
C3 INRAE; Universite de Montpellier; Universite de Montpellier; Institut
   National de la Sante et de la Recherche Medicale (Inserm); Centre
   National de la Recherche Scientifique (CNRS)
RP Coudray, C (corresponding author), Ctr INRA Montpellier, UMR Dynam Muscule Aire & Metab 866, 2 Pl Viala, F-34060 Montpellier, France.
EM Charles.coudray@inra.fr
RI COUDRAY, Charles/AGG-4757-2022
OI JOVER, Bernard/0000-0001-5826-5755; Coudray,
   Charles/0000-0003-2680-7796; Francois, Casas/0000-0002-5535-8195
FU Occitanie region (France); European Regional Development Fund
FX The results of this work are part of the Spirulicium Cardio project
   co-funded by the Occitanie region (France) and by the European Regional
   Development Fund
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NR 52
TC 1
Z9 1
U1 0
U2 12
PU WILEY-HINDAWI
PI LONDON
PA ADAM HOUSE, 3RD FL, 1 FITZROY SQ, LONDON, WIT 5HE, ENGLAND
SN 0145-8884
EI 1745-4514
J9 J FOOD BIOCHEM
JI J. Food Biochem.
PD SEP
PY 2019
VL 43
IS 9
AR e12979
DI 10.1111/jfbc.12979
EA JUL 2019
PG 13
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA IY2QK
UT WOS:000476395000001
PM 31489676
OA Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Lee, IT
   Fu, CP
   Lee, WJ
   Liang, KW
   Lin, SY
   Wan, CJ
   Sheu, WHH
AF Lee, I-Te
   Fu, Chia-Po
   Lee, Wen-Jane
   Liang, Kae-Woei
   Lin, Shih-Yi
   Wan, Chu-Jen
   Sheu, Wayne Huey-Herng
TI Brain-derived neurotrophic factor, but not body weight, correlated with
   a reduction in depression scale scores in men with metabolic syndrome: a
   prospective weight-reduction study
SO DIABETOLOGY & METABOLIC SYNDROME
LA English
DT Article
DE Exercise; Lifestyle intervention; Obesity; Zung self-rating depression
   scale
ID DISEASE RISK-FACTORS; C-REACTIVE PROTEIN; FACTOR BDNF; LIFE-STYLE;
   INSULIN-RESISTANCE; MAJOR DEPRESSION; FOOD-INTAKE; SYMPTOMS; EXERCISE;
   OBESITY
AB Background: Obesity, a critical component of metabolic syndrome (MetS), is associated with depression. Deficiency of brain-derived neurotrophic factor (BDNF) is involved in the mechanism of depression. We hypothesized that weight reduction would improve depressive symptoms via increasing BDNF levels in obese men.
   Methods: Male adults with obesity were enrolled in a weight-reduction program for twelve weeks. All subjects underwent daily caloric restriction and an exercise program which was regularly assessed in group classes. Fasting blood samples and Zung Self-Rating Depression Scale (Zung SDS) scores were collected for assessments before and after the study.
   Results: A total of 36 subjects completed this program. The average reduction in body weight was 8.4 +/- 5.1 kg (8.8 +/- 5.1%, P < 0.001). Fasting serum BDNF significantly increased after the study (from 40.4 +/- 7.8 to 46.9 +/- 8.9 ng/ml, P < 0.001). However, the depression symptoms, as assessed by the Zung Self-Rating Depression Scale (Zung SDS), did not reduce significantly (P = 0.486). Divided into subgroups based on changes in BDNF, Zung SDS scores were significantly reduced in subjects with greater BDNF increase than in those with minor BDNF change (-3.9 +/- 6.2 vs. 2.3 +/- 6.7, P = 0.009). The increased percentage of BDNF was inversely correlated with the change in Zung SDS (r = -0.380, P = 0.022). Multivariate regression analysis showed that reduction in BDNF was independently associated with change in Zung SDS (95% confidence interval -0.315 to -0.052, P = 0.008).
   Conclusion: Zung SDS only significantly improved in men with increased fasting BDNF levels after a lifestyle intervention.
C1 [Lee, I-Te; Fu, Chia-Po; Lin, Shih-Yi; Sheu, Wayne Huey-Herng] Taichung Vet Gen Hosp, Dept Internal Med, Div Endocrinol & Metab, Taichung 40705, Taiwan.
   [Lee, I-Te; Sheu, Wayne Huey-Herng] Chung Shan Med Univ, Sch Med, Taichung, Taiwan.
   [Lee, I-Te; Liang, Kae-Woei; Lin, Shih-Yi; Sheu, Wayne Huey-Herng] Natl Yang Ming Univ, Sch Med, Taipei 112, Taiwan.
   [Lee, Wen-Jane] Taichung Vet Gen Hosp, Dept Med Res, Taichung, Taiwan.
   [Liang, Kae-Woei] Taichung Vet Gen Hosp, Ctr Cardiovasc, Taichung, Taiwan.
   [Wan, Chu-Jen] Hung Kuang Univ, Dept Nutr, Taichung, Taiwan.
   [Sheu, Wayne Huey-Herng] Natl Chung Hsing Univ, Inst Med Technol, Taichung 40227, Taiwan.
C3 Taichung Veterans General Hospital; Chung Shan Medical University;
   National Yang Ming Chiao Tung University; Taichung Veterans General
   Hospital; Taichung Veterans General Hospital; Hungkuang University;
   National Chung Hsing University
RP Sheu, WHH (corresponding author), Taichung Vet Gen Hosp, Dept Internal Med, Div Endocrinol & Metab, 1650 Sect 4,Taiwan Blvd, Taichung 40705, Taiwan.
EM whhsheu@vghtc.gov.tw
OI Lee, I-Te/0000-0003-2665-3635
FU Taichung Veterans General Hospital, Taichung, Taiwan, R.O.C.
   [TCVGH-1023504C, TCVGH-PU1018101, TCVGH-983502A]; National Science
   Council, Taiwan [NSC 102-2314-B-075A-001]
FX The work was supported by grants from Taichung Veterans General
   Hospital, Taichung, Taiwan, R.O.C. (TCVGH-1023504C, TCVGH-PU1018101,
   TCVGH-983502A) and the National Science Council, Taiwan, (NSC
   102-2314-B-075A-001).
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NR 62
TC 21
Z9 21
U1 0
U2 9
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1758-5996
J9 DIABETOL METAB SYNDR
JI Diabetol. Metab. Syndr.
PD FEB 13
PY 2014
VL 6
AR 18
DI 10.1186/1758-5996-6-18
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA AB9HP
UT WOS:000332102700001
PM 24524285
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Levin, Y
   Mikulincer, M
   Solomon, Z
AF Levin, Yafit
   Mikulincer, Mario
   Solomon, Zahava
TI Prospective Effects of PTSD and Attachment on Subjective Age Among
   Veterans and Their Wives
SO PSYCHOLOGY AND AGING
LA English
DT Article
DE aging; subjective age; PTSD; attachment; dyadic processes
ID POSTTRAUMATIC-STRESS-DISORDER; WAR CAPTIVITY; PSYCHOLOGICAL DISTRESS;
   MARITAL ADJUSTMENT; METABOLIC SYNDROME; SELF-PERCEPTIONS; TELOMERE
   LENGTH; MISSING DATA; LATER LIFE; FOLLOW-UP
AB The goal of the present study was to assess the trauma-induced experience of subjective aging for trauma survivors and their spouses in relation to the bidirectional effects of posttraumatic stress disorder (PTSD) and attachment insecurities. One hundred and seventy Israeli combat veterans from the 1973 Yom Kippur War and their wives reported their subjective age (SA), 35 and 42 years after the war (T1, T2). We conducted actor-partner interdependence cross-lagged models between spouses' SA and examined the associations between T1 PTSD, T1 attachment anxiety and avoidance, and spouses' T2 SA, while controlling for chronological age. The results indicated that the wives' T1 SA positively contributed to the veterans' T2 SA and the veterans' T1 SA positively contributed to the wives' T2 SA. Veterans' T1 attachment avoidance prospectively contributed to their higher T2 SA. Wives' PTSD severity and attachment anxiety at T1 prospectively contributed to their higher T2 SA. Wives' T1 attachment avoidance contributed to their lower T2 SA. Wives' attachment anxiety and health problems at T1 prospectively contributed to veterans' reports of higher T2 SA. This study emphasizes the dyadic processes that underly trauma-related aging. The impact of dyadic processes should not be overlooked in research and clinical interventions. Specifically, effective trauma interventions during old age should take into account the impact that spouses have on trauma survivors' mental states and aging processes.
C1 [Levin, Yafit] Zurich Univ, Dept Psychol, Binzmuhlestr 14-17, CH-8050 Zurich, Switzerland.
   [Mikulincer, Mario] Interdisciplinary Ctr IDC, Sch Psychol, Herzliyya, Israel.
   [Solomon, Zahava] Tel Aviv Univ, Bob Shapell Sch Social Work, Tel Aviv, Israel.
C3 University of Zurich; Reichman University; Tel Aviv University
RP Levin, Y (corresponding author), Zurich Univ, Dept Psychol, Binzmuhlestr 14-17, CH-8050 Zurich, Switzerland.
EM ohanayaf@gmail.com
RI Levin, Yafit/MHR-0455-2025
OI Mikulincer, Mario/0000-0003-3639-0146
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NR 82
TC 3
Z9 3
U1 1
U2 14
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 0882-7974
EI 1939-1498
J9 PSYCHOL AGING
JI Psychol. Aging
PD NOV
PY 2021
VL 36
IS 7
BP 870
EP 882
DI 10.1037/pag0000640
PG 13
WC Gerontology; Psychology, Developmental
WE Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Psychology
GA WW9BO
UT WOS:000718202900007
PM 34472914
DA 2025-06-11
ER

PT J
AU Gandhi, S
   Gurusamy, J
   Ragupathy, SK
   Damodharan, D
   Ganesan, V
   Palaniappan, M
AF Gandhi, Sailaxmi
   Gurusamy, Jothimani
   Ragupathy, Sendhil Kumar
   Damodharan, Dinakaran
   Ganesan, Venkatasubramanian
   Palaniappan, Marimuthu
TI Healthy lifestyle behavior and personal control in people with
   schizophrenia with healthy controls: A cross-sectional comparative study
SO ASIAN JOURNAL OF PSYCHIATRY
LA English
DT Article
DE Healthy lifestyle behavior; Personal control; Physical health;
   Schizophrenia; Healthy controls
ID METABOLIC SYNDROME; CARE; ILLNESS; LOCUS
AB The aim of the article was to compare persons with schizophrenia and healthy controls about their life style on their physical health and personal control. Evidences highlights that it helps to change risk behaviours associated with co morbid physical health problems. Subjects were recruited from adult mental health services in tertiary level psychiatric center.Comparisons between the groups were done by using the lifestyle and personal control questionnaire. Subjects were 86 with schizophrenia, 72 were healthy controls. Results showed significant difference. However, physical health was considered to be a less important priority in their personal life by persons with schizophrenia.
C1 [Gandhi, Sailaxmi; Gurusamy, Jothimani] Natl Inst Mental Hlth & Neurosci, Dept Nursing, Bengaluru, India.
   [Ragupathy, Sendhil Kumar] Natl Inst Mental Hlth & Neurosci, Physiotherapy Ctr, Bengaluru, India.
   [Damodharan, Dinakaran; Ganesan, Venkatasubramanian] Natl Inst Mental Hlth & Neurosci, Dept Psychiat, Bengaluru, India.
   [Palaniappan, Marimuthu] Natl Inst Mental Hlth & Neurosci, Dept Biostat, Bengaluru, India.
C3 National Institute of Mental Health & Neurosciences - India; National
   Institute of Mental Health & Neurosciences - India; National Institute
   of Mental Health & Neurosciences - India; National Institute of Mental
   Health & Neurosciences - India
RP Gurusamy, J (corresponding author), Natl Inst Mental Hlth & Neurosci, Dept Nursing, Bengaluru, India.
EM jothisrinivas.jothi@gmail.com
RI Gurusamy, Jothimani/P-6729-2019; Venkatasubramanian,
   Ganesan/AAD-9117-2019
OI Gurusamy, Jothimani/0000-0002-3844-6038; Venkatasubramanian,
   Ganesan/0000-0002-0949-898X
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NR 16
TC 7
Z9 7
U1 0
U2 5
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1876-2018
EI 1876-2026
J9 ASIAN J PSYCHIATR
JI Asian J. Psychiatr.
PD OCT
PY 2019
VL 45
BP 95
EP 98
DI 10.1016/j.ajp.2019.09.008
PG 4
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychiatry
GA JF5YQ
UT WOS:000491464800022
PM 31550561
DA 2025-06-11
ER

PT J
AU Hu, LK
   Liu, YH
   Yang, K
   Chen, N
   Ma, LL
   Yan, YX
AF Hu, Li-Kun
   Liu, Yu-Hong
   Yang, Kun
   Chen, Ning
   Ma, Lin-Lin
   Yan, Yu-Xiang
TI Association between hypertriglyceridemic-waist phenotype and circadian
   syndrome risk: a longitudinal cohort study
SO HORMONES-INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM
LA English
DT Article
DE Hypertriglyceridemic-waist phenotype; Dynamic status; Circadian
   syndrome; Cohort study; China Health and Retirement Longitudinal Study
ID METABOLIC SYNDROME; OBESITY; DEPRESSION; PEOPLE; ADULTS; SLEEP; RATIO
AB Recently, circadian syndrome (CircS) has been proposed as a new predictor of cardiometabolic risk. We aimed to investigate the relationship between the hypertriglyceridemic-waist phenotype and its dynamic status with CircS in China. We conducted a two-stage study based on the China Health and Retirement Longitudinal Study (CHARLS) from 2011 to 2015. Multivariate logistic regression models in cross-sectional analysis and Cox proportional hazards regression models in longitudinal analysis were used to estimate the associations of hypertriglyceridemic-waist phenotypes with CircS and its components. We then applied multiple logistic regression analysis to evaluate the odds ratios (ORs) and 95% confidence intervals (CIs) for CircS risk by transformation into the hypertriglyceridemic-waist phenotype. A total of 9863 participants were included in the cross-sectional analysis and 3884 participants in the longitudinal analysis. Compared with normal waist circumference (WC) and normal triglyceride (TG) level (NWNT), CircS risk was increased with enlarged WC and high TG level (EWHT) (hazard ratio (HR) 3.87 [95% CI: 2.38, 5.39]). Similar results were observed in subgroup analyses by sex, age, smoking status, and drinking status. During follow-up, CircS risk was increased in group K (stable EWNT during follow-up) (OR 9.97 [95% CI: 6.41, 15.49]) compared with group A (stable NWNT during follow-up), while group L (baseline enlarged WC and normal TG level transformed to follow-up EWHT) had the highest risk of CircS (OR 116.07 [95% CI: 72.77, 185.14]). In conclusion, the hypertriglyceridemic-waist phenotype and its dynamic status were associated with the risk of developing CircS in Chinese adults.
C1 [Hu, Li-Kun; Liu, Yu-Hong; Yang, Kun; Chen, Ning; Ma, Lin-Lin; Yan, Yu-Xiang] Capital Med Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, 10 Xitoutiao, Beijing 100069, Peoples R China.
   [Yan, Yu-Xiang] Municipal Key Lab Clin Epidemiol, Beijing 100069, Peoples R China.
C3 Capital Medical University
RP Yan, YX (corresponding author), Capital Med Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, 10 Xitoutiao, Beijing 100069, Peoples R China.; Yan, YX (corresponding author), Municipal Key Lab Clin Epidemiol, Beijing 100069, Peoples R China.
EM yanyxepi@ccmu.edu.cn
RI LINLIN, MA/GZM-6143-2022
OI Yan, Yu-xiang/0000-0003-2234-1298
FU Beijing Natural Science Foundation; National Institute on Aging, United
   States [1R01AG037031]; World Bank Group [7159234]; National Natural
   Science Foundation of China, China [71130002]
FX Thanks go to the Beijing Natural Science Foundation and the National
   Natural Science Foundation of China. This current study uses data from
   the CHARLS dataset and Codebook. The development of CHARLS was funded by
   the National Institute on Aging, United States (grant number
   1R01AG037031), the World Bank Group (contract number 7159234), and the
   National Natural Science Foundation of China, China (grant number
   71130002). We are grateful to the staff of CHARLS and all the
   participants. We sincerely appreciate the data support provided by the
   CHARLS team.
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NR 44
TC 2
Z9 2
U1 3
U2 12
PU SPRINGER INT PUBL AG
PI CHAM
PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND
SN 1109-3099
EI 2520-8721
J9 HORM-INT J ENDOCRINO
JI Horm.-Int. J. Endocrinol. Metab.
PD SEP
PY 2023
VL 22
IS 3
BP 457
EP 466
DI 10.1007/s42000-023-00462-6
EA JUL 2023
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA Q0JG5
UT WOS:001024540900001
PM 37423976
DA 2025-06-11
ER

PT J
AU Zhang, M
   Chen, J
   Yin, ZQ
   Wang, LB
   Peng, LH
AF Zhang, Min
   Chen, Jing
   Yin, Zhiqun
   Wang, Lanbing
   Peng, Lihua
TI The association between depression and metabolic syndrome and its
   components: a bidirectional two-sample Mendelian randomization study
SO TRANSLATIONAL PSYCHIATRY
LA English
DT Article
ID BIPOLAR DISORDER; CAUSAL INFERENCES; BLOOD-PRESSURE; RISK-FACTORS;
   FOLLOW-UP; METAANALYSIS; SYMPTOMS; ABNORMALITIES; INDIVIDUALS;
   POPULATION
AB Observational studies suggested a bidirectional correlation between depression and metabolic syndrome (MetS) and its components. However, the causal associations between them remained unclear. We aimed to investigate whether genetically predicted depression is related to the risk of MetS and its components, and vice versa. We performed a bidirectional two-sample Mendelian randomization (MR) study using summary-level data from the most comprehensive genome-wide association studies (GWAS) of depression (n = 2,113,907), MetS (n = 291,107), waist circumference (n = 462,166), hypertension (n = 463,010) fasting blood glucose (FBG, n = 281,416), triglycerides (n = 441,016), high-density lipoprotein cholesterol (HDL-C, n = 403,943). The random-effects inverse-variance weighted (IVW) method was applied as the primary method. The results identified that genetically predicted depression was significantly positive associated with risk of MetS (OR: 1.224, 95% CI: 1.091-1.374, p = 5.58 x 10(-4)), waist circumference (OR: 1.083, 95% CI: 1.027-1.143, p = 0.003), hypertension (OR: 1.028, 95% CI: 1.016-1.039, p = 1.34 x 10(-6)) and triglycerides (OR: 1.111, 95% CI: 1.060-1.163, p = 9.35 x 10(-6)) while negative associated with HDL-C (OR: 0.932, 95% CI: 0.885-0.981, p = 0.007) but not FBG (OR: 1.010, 95% CI: 0.986-1.034, p = 1.34). No causal relationships were identified for MetS and its components on depression risk. The present MR analysis strength the evidence that depression is a risk factor for MetS and its components (waist circumference, hypertension, FBG, triglycerides, and HDL-C). Early diagnosis and prevention of depression are crucial in the management of MetS and its components.
C1 [Zhang, Min] Chongqing Med Univ, Sch Publ Hlth & Management, Chongqing 400016, Peoples R China.
   [Chen, Jing; Peng, Lihua] Chongqing Med Univ, Dept Anesthesia & Pain Med, Affiliated Hosp 1, Chongqing 400016, Peoples R China.
   [Yin, Zhiqun] 964 Hosp Peoples Liberat Army, Dept Psychiat & Psychol, Changchun 130026, Jilin, Peoples R China.
   [Wang, Lanbing] Army Mil Med Univ, Div Med Affairs, Affiliated Hosp 1, Chongqing 400038, Peoples R China.
C3 Chongqing Medical University; Chongqing Medical University
RP Peng, LH (corresponding author), Chongqing Med Univ, Dept Anesthesia & Pain Med, Affiliated Hosp 1, Chongqing 400016, Peoples R China.
EM plhcqmu@163.com
OI Peng, Lihua/0000-0002-5202-910X
FU Health Bureau of Chongqing Municipality [2020jstg026, 2020MSXM042];
   Chongqing Science and Technology Commission [2020MSXM042]
FX Quality Control filtering of the UK Biobank data was conducted by
   R.Mitchell, G. Hemani, T.Dudding, and L.Paternoster as described in the
   published protocol
   (https://doi.org/10.5523/bris.3074krb6t2frj29yh2b03x3wxj).We thank the
   PGC, MAGIC, and MRC-IEU UK Biobank for providing the summary-level data
   used in this study. This study was supported by the medical research
   projects sponsored by the Health Bureau of Chongqing Municipality and
   Chongqing Science and Technology Commission (2020MSXM042) and the
   technology promotion projects sponsored by the Health Bureau of
   Chongqing Municipality (2020jstg026). The funding agencies of this study
   had no role in study design, data collection, data management, data
   analysis, data interpretation, writing of the manuscript, or the
   decision for submission.
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NR 71
TC 83
Z9 83
U1 2
U2 20
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 2158-3188
J9 TRANSL PSYCHIAT
JI Transl. Psychiatr.
PD DEC 13
PY 2021
VL 11
IS 1
AR 633
DI 10.1038/s41398-021-01759-z
PG 9
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA XN9DG
UT WOS:000729797000005
PM 34903730
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Tamtaji, OR
   Milajerdi, A
   Reiner, Z
   Dadgostar, E
   Amirani, E
   Asemi, Z
   Mirsafaei, L
   Mansournia, MA
   Dana, PM
   Sadoughi, F
   Hallajzadeh, J
AF Tamtaji, Omid Reza
   Milajerdi, Alireza
   Reiner, Zeljko
   Dadgostar, Ehsan
   Amirani, Elaheh
   Asemi, Zatollah
   Mirsafaei, Liaosadat
   Mansournia, Mohammad Ali
   Dana, Parisa Maleki
   Sadoughi, Fatemeh
   Hallajzadeh, Jamal
TI Effects of flaxseed oil supplementation on biomarkers of inflammation
   and oxidative stress in patients with metabolic syndrome and related
   disorders: A systematic review and meta-analysis of randomized
   controlled trials
SO CLINICAL NUTRITION ESPEN
LA English
DT Review
DE Flaxseed oil; Metabolic syndrome; Inflammation; Oxidative stress;
   Meta-analysis
ID C-REACTIVE PROTEIN; POLYUNSATURATED FATTY-ACIDS; OMEGA-3-FATTY-ACIDS
   SUPPLEMENTATION; GLUCOSE-HOMEOSTASIS; DENSITY-LIPOPROTEIN;
   GENE-EXPRESSION; DOUBLE-BLIND; MARKERS; HMGB1; INTERVENTION
AB Objective: This systematic review and meta-analysis of randomized controlled trials (RCTs) was performed to analyze the effects of flaxseed oil supplementation on biomarkers of inflammation and oxidative stress in patients with metabolic syndrome (MetS) and related disorders.
   Methods: Databases including PubMed, Scopus, EMBASE, Web of Science, and Cochrane Central library were searched until January 31th, 2019.
   Results: 14 effect sizes from 12 studies were identified eligible to be included in current meta-analysis. Flaxseed supplementation resulted in a significant reduction in interleukin 6 (IL-6) (WMD: -0.22; 95% CI: -0.43, -0.01) and malondialdehyde (MDA) (WMD: -0.17; 95% CI: -0.31, -0.03) and a significant increase in total antioxidant capacity (TAC) levels (WMD: 137.25; 95% CI: 68.04, 206.47). Flaxseed oil supplementation did not affect other biomarkers of inflammation and oxidative stress.
   Conclusions: Overall, this meta-analysis demonstrated flaxseed oil supplementation decreased IL-6 and MDA levels, and increased TAC, but did not affect other biomarkers of inflammation and oxidative stress among patients with MetS and related disorders. This suggests that flaxseed oil supplementation may have played an indirect role in improved clinical symptoms in diseases with metabolic disorders. (C) 2020 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights reserved.
C1 [Tamtaji, Omid Reza; Amirani, Elaheh; Asemi, Zatollah; Dana, Parisa Maleki; Sadoughi, Fatemeh] Kashan Univ Med Sci, Res Ctr Biochem & Nutr Metab Dis, Kashan, Iran.
   [Milajerdi, Alireza] Univ Tehran Med Sci, Students Sci Res Ctr, Tehran, Iran.
   [Reiner, Zeljko] Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Community Nutr, Tehran, Iran.
   [Dadgostar, Ehsan] Univ Zagreb, Univ Hosp Ctr Zagreb, Sch Med, Dept Internal Med, Zagreb, Croatia.
   [Mirsafaei, Liaosadat] FDA, Halal Res Ctr IRI, Tehran, Iran.
   [Mansournia, Mohammad Ali] Mazandaran Univ Med Sci, Dept Cardiol, Ramsar Campus, Sari, Iran.
   [Hallajzadeh, Jamal] Univ Tehran Med Sci, Sch Publ Hlth, Dept Epidemiol & Biostat, Tehran, Iran.
C3 Tehran University of Medical Sciences; Tehran University of Medical
   Sciences; University of Zagreb; UNIVERSITY ZAGREB HOSPITAL; Mazandaran
   University of Medical Sciences; Tehran University of Medical Sciences
RP Hallajzadeh, J (corresponding author), Maragheh Univ Med Sci, Res Ctr Evidence Based Hlth Management, Maragheh, Iran.
EM tamtaji.or@gmail.com; Alimila66@gmail.com; zeljko.reiner@kbc-zagreb.hr;
   ehsandadgostar71@gmail.com; elahe.amirani@rocketmail.com;
   asemi_r@yahoo.com; Liaosadat.mirsafaei@gmail.com;
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RI asemi, zatollah/J-2677-2018; Mirsafaei, ;iaosadat/AAX-3017-2020;
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   tamtaji, M/KWU-3655-2024
OI Maleki Dana, Parisa/0000-0003-2544-548X
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NR 37
TC 18
Z9 19
U1 0
U2 8
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2405-4577
J9 CLIN NUTR ESPEN
JI Clin. Nutr. ESPEN
PD DEC
PY 2020
VL 40
BP 27
EP 33
DI 10.1016/j.clnesp.2020.09.017
PG 7
WC Nutrition & Dietetics
WE Emerging Sources Citation Index (ESCI)
SC Nutrition & Dietetics
GA QB3YQ
UT WOS:000614078200004
PM 33183549
DA 2025-06-11
ER

PT J
AU von Ehrlich, B
   Barbagallo, M
   Classen, HG
   Guerrero-Romero, F
   Mooren, FC
   Rodriguez-Moran, M
   Vierling, W
   Vormann, J
   Kisters, K
AF von Ehrlich, B.
   Barbagallo, M.
   Classen, H. G.
   Guerrero-Romero, F.
   Mooren, F. C.
   Rodriguez-Moran, M.
   Vierling, W.
   Vormann, J.
   Kisters, K.
TI Significance of magnesium in insulin resistance, metabolic syndrome, and
   diabetes recommendations of the Association of Magnesium Research e.V
SO TRACE ELEMENTS AND ELECTROLYTES
LA English
DT Article
ID LOWER SERUM MAGNESIUM; LOW PLASMA MAGNESIUM; DIETARY MAGNESIUM;
   DOUBLE-BLIND; INTRACELLULAR MAGNESIUM; ATHEROSCLEROSIS-RISK; NONDIABETIC
   SUBJECTS; MELLITUS TYPE-2; SUPPLEMENTATION; HYPOMAGNESEMIA
AB Magnesium (Mg) depletion is an important and highly prevalent condition in patients with diabetes or precursor states of type-2 diabetes like metabolic syndrome. Mg deficiency increases the risk of developing type-2 diabetes. These recommendations compile present data on the physiology of Mg in carbohydrate metabolism and pathophysiological consequences of Mg depletion for diabetics. Diabetes patients and candidates benefit from four categories of Mg effects: insulin-sensitizing effect, calcium antagonism, stress-regulating and endotheli-um-stabilizing effects. Clinical data with Mg co-medication show improvement of insulin resistance/blood glucose level and reduced long-term vascular damages in surrogate parameters. High serum Mg is associated with lower prevalence of retinopathy; severity of retinopathy is associated with the degree of Mg depletion. High serum Mg is also associated with less deterioration of renal func-tion in diabetics. Depression, a comorbidity of diabetes, is less prevalent in patients with high serum Mg. A standardized regime for diagnosing Mg depletion and a regime for supplementing these patients is outlined. Diagnosis of Mg depletion is simple, predominantly by a synoptic view of patient history and clinical or/and laboratory data.
C1 [Barbagallo, M.] Univ Palermo, Inst Internal Med & Geriatr, Palermo, Italy.
   [Classen, H. G.] Univ Stuttgart Hohenheim, Stuttgart, Germany.
   [Guerrero-Romero, F.; Rodriguez-Moran, M.] Mexican Social Secur Inst, Biomed Res Inst, Durango, Mexico.
   [Mooren, F. C.] Justus Liebig Univ Giessen, Inst Sports Sci, Dept Sports Med, Giessen, Germany.
   [Vierling, W.] Tech Univ Munich, Inst Pharmacol & Toxicol, Munich, Germany.
   [Vormann, J.] Inst Prevent & Nutr, Ismaning, Germany.
   [Kisters, K.] St Anna Hosp, Med Clin 1, Herne, Germany.
C3 University of Palermo; University Hohenheim; Instituto Mexicano del
   Seguro Social; Justus Liebig University Giessen; Technical University of
   Munich; Ruhr University Bochum; Saint Anna Hospital
RP Barbagallo, M (corresponding author), Univ Palermo, Inst Internal Med & Geriatr, Palermo, Italy.
RI Vormann, Jürgen/F-5055-2016; BARBAGALLO, MARIO/K-4794-2017
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NR 62
TC 7
Z9 7
U1 0
U2 6
PU DUSTRI-VERLAG DR KARL FEISTLE
PI DEISENHOFEN-MUENCHEN
PA BAHNHOFSTRASSE 9 POSTFACH 49, D-82032 DEISENHOFEN-MUENCHEN, GERMANY
SN 0946-2104
J9 TRACE ELEM ELECTROLY
JI Trace Elem. Electrolytes
PY 2017
VL 34
IS 3
BP 124
EP 129
DI 10.5414/TEX01473
PG 6
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA FA1BO
UT WOS:000405173500007
DA 2025-06-11
ER

PT J
AU Creus, A
   Chicco, A
   Alvarez, SM
   Giménez, MS
   de Lombardo, YB
AF Creus, Agustina
   Chicco, Adriana
   Alvarez, Silvina M.
   Gimenez, Maria S.
   Bolzon de Lombardo, Yolanda
TI Dietary Salvia hispanica L. reduces cardiac oxidative stress of
   dyslipidemic insulin-resistant rats
SO APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
LA English
DT Article
DE oxidative stress; left ventricle heart muscle; Salvia hispanica L.;
   sucrose-rich diet; metabolic syndrome; alpha-linolenic acid
ID INDUCED METABOLIC SYNDROME; SUCROSE-RICH DIET; HIGH-CARBOHYDRATE;
   MORPHOLOGICAL-CHANGES; FRUCTOSE; GLUCOSE; IMPROVES; LIVER; HEART;
   ACTIVATION
AB Salvia hispanica L., commonly known as chia seed, has beneficial effects upon some signs of metabolic syndrome (MS), such as dyslipidemia and insulin resistance. However, its action on cardiac oxidative stress associated with MS remains unknown. The goal of this study was to analyze the possible beneficial effects of chia seed (variety Salba) upon the oxidative stress of left ventricle heart muscle (LV) of a well-established dyslipidemic insulin-resistant rat model induced by feeding them a sucrose-rich diet (SRD). Male Wistar rats received an SRD for 3 months. After that, for 3 additional months, half of the animals continued with the SRD, while the other half received the SRD containing chia as the source of dietary fat instead corn oil (SRD+chia). In the LV of SRD-fed rats, chia seed improved/reverted the depleted activity of antioxidant enzymes glutathione peroxidase, superoxide dismutase (SOD), and catalase, and ameliorated manganese superoxide dismutase messenger RNA (mRNA) levels increasing the expression of the nuclear factor erythroid 2-related factor 2 (Nrf2). Improved the glutathione redox estate, reactive oxygen species, and thiobarbituric acid reactive substances contents normalizing the p47NOX subunit mRNA level. Furthermore, chia normalized hypertension and plasma levels of pro-inflammatory cytokines and oxidative stress biomarkers. The findings show that chia seed intake impacts positively upon oxidative imbalance of LV of dyslipidemic insulin-resistant rats.
C1 [Creus, Agustina; Chicco, Adriana; Bolzon de Lombardo, Yolanda] Univ Litoral, Sch Biochem, Dept Biochem, Ciudad Univ,CC 242, RA-3000 Santa Fe, Argentina.
   [Alvarez, Silvina M.; Gimenez, Maria S.] Natl Univ San Luis, Fac Chem Biochem & Pharm, Lab Mol Biochem, Ave Ejercito Los Andes 950, San Luis, Argentina.
   [Alvarez, Silvina M.; Gimenez, Maria S.] Consejo Nacl Invest Cient & Tecn, IMIBIO SL, San Luis, Argentina.
C3 National University of the Littoral; Universidad Nacional de San Luis;
   Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET)
RP Creus, A (corresponding author), Univ Litoral, Sch Biochem, Dept Biochem, Ciudad Univ,CC 242, RA-3000 Santa Fe, Argentina.
EM acreus@fbcb.unl.edu.ar
RI Alvarez, Silvina/GOE-5780-2022; Creus, Agustina/AAW-7578-2020
OI Creus, Agustina/0000-0001-9589-0058; Alvarez,
   Silvina/0000-0001-7522-7208
FU Agencia Nacional de Promocion Cientifica y Tecnologica (ANPCyT),
   Argentina [PICT 945 BID OC/AR 2011]; University of Litoral (UNL),
   Argentina [CAI+D 0058 LI-2012]
FX The authors thank Silvia Rodriguez and Walter Da Ru for their technical
   assistance and Agrisalba S.A., Buenos Aires, Argentina, for providing
   the Salba chia seed. The present study was supported by grants from
   Agencia Nacional de Promocion Cientifica y Tecnologica (ANPCyT),
   Argentina (PICT 945 BID OC/AR 2011), and the University of Litoral
   (UNL), Argentina (CAI+D 0058 LI-2012).
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NR 35
TC 10
Z9 10
U1 0
U2 5
PU CANADIAN SCIENCE PUBLISHING
PI OTTAWA
PA 65 AURIGA DR, SUITE 203, OTTAWA, ON K2E 7W6, CANADA
SN 1715-5312
EI 1715-5320
J9 APPL PHYSIOL NUTR ME
JI Appl. Physiol. Nutr. Metab.
PD JUL
PY 2020
VL 45
IS 7
BP 761
EP 768
DI 10.1139/apnm-2019-0769
PG 8
WC Nutrition & Dietetics; Physiology; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics; Physiology; Sport Sciences
GA MH4GL
UT WOS:000546689600010
PM 31935117
DA 2025-06-11
ER

PT J
AU Nguyen, TV
   Damiani, G
   Orenstein, LAV
   Hamzavi, I
   Jemec, GB
AF Nguyen, T., V
   Damiani, G.
   Orenstein, L. A., V
   Hamzavi, I
   Jemec, G. B.
TI Hidradenitis suppurativa: an update on epidemiology, phenotypes,
   diagnosis, pathogenesis, comorbidities and quality of life
SO JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
LA English
DT Review
ID INFLAMMATORY-BOWEL-DISEASE; PATIENT CLAIMS DATA; SEVERITY ASSESSMENT;
   METABOLIC SYNDROME; SCORING SYSTEM; OLMSTED COUNTY; SEXUAL HEALTH;
   PREVALENCE; POPULATION; ACNE
AB Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease that severely impairs patients' quality of life. It is characterized by recurrent painful nodules, abscesses and draining sinus tracts in primarily intertriginous areas. We aimed to review the most up-to-date information regarding the epidemiology, clinical presentation, diagnostic studies, pathogenesis, comorbidities and quality of life of patients with hidradenitis suppurativa. We performed a systematic search of Medline, Embase database (from inception to September 2019) and review of bibliographies without restrictions on year or language. HS has an estimated global prevalence of 0.00033-4.1% (but most likely 0.7-1.2% in the European-US population). Patients still experience a significant diagnostic delay, up to several years. In the absence of pathognomonic tests, the diagnosis of HS is made from clinical observation and the disease narrative. Phenotypic variation renders diagnosis and severity assessment difficult. Ultrasound imaging is an emerging assessment tool for deepseated lesions. The Hurley Staging System is still widely used in severity rating. Follicular hyperkeratosis and dilatation, follicular rupture and chronic inflammation with architectural tissue changes have been implicated in the pathogenesis of HS. HS has been associated with metabolic syndrome and other risk factors for cardiovascular disease, diabetes mellitus type II, polycystic ovarian syndrome, depression, suicide and substance use disorders. It has been linked to other immune-mediated diseases such as inflammatory bowel disease and spondyloarthropathy. Pain, pruritus, malodour, low self-esteem, sleep and sexual dysfunctions, and poor mental health are chronic symptoms or consequences of uncontrolled disease. HS is an under-diagnosed and under-treated disease with a profound negative impact on patients' quality of life. In the light of its associated comorbidities, an interdisciplinary management approach may be needed to ensure the best outcomes.
C1 [Nguyen, T., V] Bellevue Dermatol Clin & Clin Res Ctr, Bellevue, WA 98004 USA.
   [Damiani, G.] Emory Univ, Sch Med, Dept Dermatol, Atlanta, GA 30322 USA.
   [Orenstein, L. A., V] Univ Milan, Dipartimento Fisiopatol Med Chirurg & Trapianti, Unita Operat Dermatol, IRCCS Fdn Ca Granda,Osped Maggiore Policlin, Milan, Italy.
   [Hamzavi, I] Henry Ford Hosp, Dept Dermatol, Detroit, MI 48202 USA.
   [Jemec, G. B.] Zealand Univ Hosp, Dept Dermatol, Roskilde, Denmark.
C3 Emory University; IRCCS Ca Granda Ospedale Maggiore Policlinico;
   University of Milan; Henry Ford Health System; Henry Ford Hospital
RP Nguyen, TV (corresponding author), Bellevue Dermatol Clin & Clin Res Ctr, Bellevue, WA 98004 USA.
EM letien62nguyen@gmail.com
RI Hamzavi, Iltefat/AAW-7320-2021; Damiani, Giovanni/AAG-6507-2019; Nguyen,
   Tien/KAL-6788-2024; Jemec, Gregor/H-6702-2019
OI Nguyen, Tien/0000-0002-5646-6286; Jemec, Gregor/0000-0002-0712-2540;
   Damiani, Giovanni/0000-0002-2390-6505
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NR 188
TC 247
Z9 254
U1 5
U2 17
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0926-9959
EI 1468-3083
J9 J EUR ACAD DERMATOL
JI J. Eur. Acad. Dermatol. Venereol.
PD JAN
PY 2021
VL 35
IS 1
BP 50
EP 61
DI 10.1111/jdv.16677
EA JUL 2020
PG 12
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA PR5VF
UT WOS:000548682700001
PM 32460374
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Uutela, T
   Kautiainen, H
   Järvenpää, S
   Salomaa, S
   Hakala, M
   Häkkinen, A
AF Uutela, T.
   Kautiainen, H.
   Jarvenpaa, S.
   Salomaa, S.
   Hakala, M.
   Hakkinen, A.
TI Waist circumference based abdominal obesity may be helpful as a marker
   for unmet needs in patients with RA
SO SCANDINAVIAN JOURNAL OF RHEUMATOLOGY
LA English
DT Article
ID RHEUMATOID-ARTHRITIS PATIENTS; CARDIOVASCULAR RISK-FACTORS;
   QUALITY-OF-LIFE; METABOLIC SYNDROME; DISEASE; ASSOCIATION; PREVALENCE;
   WOMEN; MASS
AB Objectives: To assess the impact of abdominal obesity (AO) on disease severity, cardiovascular risk factors, and patient-reported outcomes (PROs) in patients with rheumatoid arthritis (RA).
   Method: Two hundred and thirty consecutive outpatients were cross-sectionally assessed. Waist circumference (WC) with a cut-off point of >= 102 cm in men and >= 88 cm in women indicated AO. Clinical assessment included joint counts, radiographs of small joints, and laboratory tests. Comorbidities and medication were verified from the patients' database. Patient questionnaires included sociodemographics, pain intensity, global disease activity, the Beck Depression Inventory (BDI), the Health Assessment Questionnaire (HAQ), physical activity level, and the 36-item Short Form Health Survey (SF-36). Metabolic syndrome (MetS) was defined according to the criteria of National Cholesterol Education Program (NCEP) Adult Treatment Panel III (ATP III). The association of AO with the 28-joint count Disease Activity Score (DAS28) and mental (MCS) and physical component scores (PCS) of the SF-36 and the HAQ was assessed by using regression models with the propensity score as a covariate.
   Results: The AO prevalence was 52% in the 200 eligible patients. In a univariate analysis, AO was associated with cardiovascular risk factors, low HAQ score, physical inactivity, disease activity parameters, impaired MCS, higher pain, and increased use of biological drugs and antidepressants. In a multivariable model, only poorer DAS28 (p = 0.018) and poorer HAQ score (p = 0.004) remained significantly associated with AO.
   Conclusions: AO is highly prevalent in patients with RA. In addition to cardiovascular risk factors, AO is associated with higher disease activity, higher disability, physical inactivity, more patients' perception of pain, and poorer mental health. Multifaceted promotion of lifestyle habits would be beneficial for improving AO-related health outcomes in patients with RA.
C1 [Uutela, T.; Salomaa, S.] Cent Hosp Lapland, Dept Med, FI-96101 Rovaniemi, Lapland, Finland.
   [Uutela, T.] Univ Oulu, Dept Med, SF-90100 Oulu, Finland.
   [Kautiainen, H.] Helsinki Univ Hosp, Dept Primary Hlth Care & Gen Practice, Helsinki, Finland.
   [Jarvenpaa, S.] Medcare Fdn, Aanekoski, Finland.
   [Hakala, M.] Univ Tampere, Dept Musculoskeletal Med & Rehabil, FIN-33101 Tampere, Finland.
   [Hakala, M.] Paijat Hame Cent Hosp, Lahti, Finland.
   [Hakkinen, A.] Univ Jyvaskyla, Dept Hlth Sci, SF-40351 Jyvaskyla, Finland.
   [Hakkinen, A.] Cent Finland Hosp, Dept Phys & Rehabil Med, Jyvaskyla, Finland.
C3 University of Oulu; University of Helsinki; Helsinki University Central
   Hospital; Tampere University; Paijat Hame Central Hospital; University
   of Jyvaskyla; Central Finland Central Hospital
RP Uutela, T (corresponding author), Cent Hosp Lapland, Dept Med, Ounasrintentie 22,POB 8041, FI-96101 Rovaniemi, Lapland, Finland.
EM toini.uutela@fimnet.fi
OI Hakkinen, Arja/0000-0002-5779-1259
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NR 38
TC 11
Z9 11
U1 0
U2 2
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0300-9742
EI 1502-7732
J9 SCAND J RHEUMATOL
JI Scand. J. Rheumatol.
PY 2014
VL 43
IS 4
BP 279
EP 285
DI 10.3109/03009742.2013.858769
PG 7
WC Rheumatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Rheumatology
GA AN3CF
UT WOS:000340461800004
PM 24467375
DA 2025-06-11
ER

PT J
AU Tsou, MT
   Pai, TP
   Chiang, TM
   Huang, WH
   Lin, HM
   Lee, SC
AF Tsou, Meng-Ting
   Pai, Tsung-Ping
   Chiang, Te-Ming
   Huang, Wei-Hsin
   Lin, Hsiu-Mei
   Lee, Shu-Chen
TI Burnout and metabolic syndrome among different departments of medical
   center nurses in Taiwan-Cross-sectional study and biomarker research
SO JOURNAL OF OCCUPATIONAL HEALTH
LA English
DT Article
DE biomarker; burnout; metabolic syndrome; nurses; Taiwan
ID WORKING HOURS; LIFE-STYLE; STRESS; PREVALENCE; ASSOCIATION; VALIDITY;
   DISEASE; OBESITY; RISK; MEN
AB Objectives: The cross-sectional study aimed to analyze the association between burnout, work-related factors, and metabolic syndrome (Mets) in nurses from several departments of a tertiary hospital in Taiwan. Exploring biomarkers could provide for prevention.
   Methods: Demographic data were obtained through a written questionnaire and include the following information: gender, age, education level, psychosocial and work situations, such as departments, working hours, work shift, depression, and sleep time. Burnout was evaluated according to the Chinese Burnout inventory, Mets was evaluated according to the criteria of the National Cholesterol Education Program of Taiwan-Treatment Panel for Adults III (NCEP-ATP III).
   Results: A total of 1758 nurses participated with a median age of 35.2 years. The prevalence of burnout and Mets was 6.4% and 13.84%, respectively. The results showed that burnout induced higher risk of Mets, odds ratio (OR) 1.70 (95% confidence interval, 1.04-3.05). Other factors, such as out-patient nurses, seniority (4-10 and >10 years), working hours (51-59 h/wk), nigh shift, Brief Symptom Rating Scale-5 (score 10-14 and >= 5), poor self-rated health status, and inadequate sleep time, led to higher risk of Mets. Biomarkers research showed that Glycated hemoglobin (Hba1c) was significantly associated with burnout nurses (OR = 24.72, P < .001), but thyroid-stimulating hormone and free thyroxin were not.
   Conclusions: Results suggested positive associations between burnout and Mets in nurses. For nurses with higher seniority, long hours of work, night shifts, poor physical and mental conditions, and poor lifestyle habits in different departments, strategies are needed to prevent burnout and Mets.
C1 [Tsou, Meng-Ting; Chiang, Te-Ming; Huang, Wei-Hsin] Mackay Mem Hosp, Dept Family Med, Taipei, Taiwan.
   [Tsou, Meng-Ting; Huang, Wei-Hsin] Mackay Mem Hosp, Dept Occupat Med, Taipei, Taiwan.
   [Tsou, Meng-Ting] Mackay Jr Coll Med Nursing & Management, New Taipei, Taiwan.
   [Pai, Tsung-Ping] Lian Xin Clin, Dept Family Med & Occupat Med, Taoyuan, Taiwan.
   [Huang, Wei-Hsin] Mackay Med Coll, Dept Med, New Taipei, Taiwan.
   [Lin, Hsiu-Mei] Mackay Mem Hosp, Dept Occupat Safety & Hlth, Taipei, Taiwan.
   [Lee, Shu-Chen] Mackay Mem Hosp, Dept Community Hlth Ctr, Taipei, Taiwan.
C3 Mackay Memorial Hospital; Mackay Memorial Hospital; Mackay Junior
   College of Medicine, Nursing & Management; Mackay Medical College;
   Mackay Memorial Hospital; Mackay Memorial Hospital
RP Tsou, MT (corresponding author), 92,Sec 2,Zhongshan N Rd, Taipei 10449, Taiwan.
EM mttsou@gmail.com
FU Mackay Memorial Hospital Medical Research Department "Special Research
   Study" [MMH-107154]
FX Mackay Memorial Hospital Medical Research Department "Special Research
   Study", Grant/Award Number: MMH-107154
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NR 46
TC 15
Z9 15
U1 2
U2 16
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1341-9145
EI 1348-9585
J9 J OCCUP HEALTH
JI J. Occup. Health
PD JAN-DEC
PY 2021
VL 63
IS 1
AR e12188
DI 10.1002/1348-9585.12188
PG 13
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA QS8DF
UT WOS:000626123500003
PM 33469969
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Razali, NA
   Daud, TIM
   Woon, LSC
   Saini, SM
   Muhammad, NA
   Sharip, S
AF Razali, Nur Atikah
   Daud, Tuti Iryani Mohd
   Woon, Luke Sy-Cherng
   Saini, Suriati Mohamed
   Muhammad, Noor Azimah
   Sharip, Shalisah
TI Case report: Bipolar disorder in 48,XXYY syndrome
SO FRONTIERS IN PSYCHIATRY
LA English
DT Article
DE case report; bipolar mood disorder; metabolic syndrome; aggression; 48;
   XXYY syndrome
ID INTELLECTUAL DISABILITIES; METABOLIC SYNDROME; 49,XXXXY
AB 48,XXYY syndrome is a rare condition. The presentations of impulsive and aggressive behavior have been reported in several case reports among patients with 48,XXYY syndrome. The management of the psychological impact and neuropsychiatric sequela of this condition is a significant issue faced by families, carers, and healthcare professionals. We report a patient, 21-year-old Malay male, with underlying 48,XXYY syndrome with attention deficit hyperactivity disorder (ADHD) and intellectual disability, diagnosed later in adulthood with a bipolar mood disorder and benefited after being started on lithium. We describe the key clinical features and diagnostic workouts that allowed the arrival of the correct psychiatric diagnosis. Challenges in psychopharmacotherapy, including the risks of metabolic syndrome and deep vein thrombosis associated with 48,XXYY syndrome, are also considered. We suggest that for patients with 48,XXYY syndrome, routine psychological screening for mood symptoms such as mania and depression should be done by healthcare professionals with early involvement of psychiatrist in the multidisciplinary team due to the challenges in the management of these patients.
C1 [Razali, Nur Atikah; Daud, Tuti Iryani Mohd; Woon, Luke Sy-Cherng; Saini, Suriati Mohamed; Sharip, Shalisah] Univ Kebangsaan Malaysia, Fac Med, Dept Psychiat, Med Ctr, Kuala Lumpur, Malaysia.
   [Muhammad, Noor Azimah] Univ Kebangsaan Malaysia, Fac Med, Dept Family Med, Med Ctr, Kuala Lumpur, Malaysia.
C3 Universiti Kebangsaan Malaysia; Universiti Kebangsaan Malaysia
RP Daud, TIM (corresponding author), Univ Kebangsaan Malaysia, Fac Med, Dept Psychiat, Med Ctr, Kuala Lumpur, Malaysia.
EM tutimd@ppukm.ukm.edu.my
RI Daud, Tuti/M-5626-2017; Muhammad, Noor/ITV-6241-2023; Sy-Cherng,
   Luke/AAQ-8740-2020; Sharip, Shalisah/Q-2574-2018; Saini,
   Suriati/AAH-6704-2019
CR Bhaumik S, 2007, BRIT J DEV DISABIL, V53, P37, DOI 10.1179/096979507799103496
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NR 21
TC 1
Z9 1
U1 0
U2 4
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-0640
J9 FRONT PSYCHIATRY
JI Front. Psychiatry
PD JAN 11
PY 2023
VL 13
AR 1080698
DI 10.3389/fpsyt.2022.1080698
PG 7
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 8G0PB
UT WOS:000920053200001
PM 36713919
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU D'Ambrosio, V
   Salvi, V
   Bogetto, F
   Maina, G
AF D'Ambrosio, Virginia
   Salvi, Virginio
   Bogetto, Filippo
   Maina, Giuseppe
TI Serum lipids, metabolic syndrome and lifetime suicide attempts in
   patients with bipolar disorder
SO PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
LA English
DT Review
DE Bipolar disorder; Cholesterol; Lipids; Suicide attempts; Metabolic
   syndrome
ID LOW PLASMA-CHOLESTEROL; RISK-FACTORS; PSYCHIATRIC-INPATIENTS; MAJOR
   DEPRESSION; BEHAVIOR; PREVALENCE; VIOLENT; NONATTEMPTERS; METAANALYSIS;
   OVERWEIGHT
AB Objective: Bipolar disorder is associated with a high risk of suicide. Many clinical characteristics and, recently, biomarkers have been studied with the aim to find useful predictors of suicidality. The role of serum lipids has also been explored albeit with conflicting results; however, few studies have been focused on patients with bipolar disorder. Aim of our study is to investigate whether serum cholesterol, triglycerides, HDL-c and metabolic syndrome are associated with lifetime suicide attempts in a large naturalistic sample of patients with bipolar disorder.
   Methods: 220 patients with bipolar disorder were included. History of lifetime suicide attempts was systematically and retrospectively assessed for each patient. Blood exams testing total cholesterol, triglycerides, and HDL-c levels were performed, and metabolic syndrome was diagnosed according to NCEP ATP-III modified criteria. Serum lipid levels and metabolic syndrome were compared in patients with or without history of suicide attempt. According to a theory that links impulsivity and violence with low cholesterol, the association between lipid levels and violent suicidal behavior was also assessed.
   Results: Lifetime suicide attempts rate was 32.3%. There were no statistically significant differences between patients with and without lifetime suicide attempts in cholesterol, triglycerides, HDL-c levels, and the prevalence of metabolic syndrome. No differences in the same variables were found in violent suicide attempters compared with nonviolent ones. Clinical characteristics such as gender, low education, higher number of manic and depressive episodes, and taking more medications for bipolar disorder were associated with lifetime suicide attempts.
   Conclusions: Our results do not support the hypothesis of a strong association between serum lipid levels and suicide in patients with bipolar disorder. (c) 2012 Elsevier Inc. All rights reserved.
C1 [D'Ambrosio, Virginia; Salvi, Virginio; Bogetto, Filippo; Maina, Giuseppe] Univ Turin, Mood & Anxiety Disorders Unit, Dept Neurosci, I-10126 Turin, TO, Italy.
C3 University of Turin
RP Maina, G (corresponding author), Univ Turin, Mood & Anxiety Disorders Unit, Dept Neurosci, Via Cherasco 11, I-10126 Turin, TO, Italy.
EM giuseppe.maina@unito.it
RI Maina, Giuseppe/AAC-7158-2022; Salvi, Virginio/C-8208-2013
OI SALVI, Virginio/0000-0003-3374-018X; Maina, Giuseppe/0000-0002-2533-140X
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NR 57
TC 53
Z9 55
U1 0
U2 23
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0278-5846
EI 1878-4216
J9 PROG NEURO-PSYCHOPH
JI Prog. Neuro-Psychopharmacol. Biol. Psychiatry
PD APR 27
PY 2012
VL 37
IS 1
BP 136
EP 140
DI 10.1016/j.pnpbp.2011.12.009
PG 5
WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA 924DW
UT WOS:000302672300020
PM 22230650
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Parletta, N
   Aljeesh, Y
   Baune, BT
AF Parletta, Natalie
   Aljeesh, Yousef
   Baune, Bernhard T.
TI Health Behaviors, Knowledge, Life Satisfaction, and Wellbeing in People
   with Mental Illness across Four Countries and Comparisons with Normative
   Sample
SO FRONTIERS IN PSYCHIATRY
LA English
DT Article
DE mental illness; diet; lifestyle; sleep; health knowledge; education
ID QUALITY-OF-LIFE; CARDIOMETABOLIC RISK; METABOLIC SYNDROME; PSYCHOTIC
   ILLNESS; PHYSICAL-ACTIVITY; MOOD DISORDERS; ASSOCIATION; SCHIZOPHRENIA;
   DEPRESSION; SOCIOECONOMICS
AB Background: People with chronic mental illness have poorer physical health and higher mortality than the general population. We investigated lifestyle factors in people with mental illness across four countries and compared with a normative sample.
   Design and methods: Data were collected from N = 672 people (Germany, n = 375; Palestine, n = 192; London, n = 63; Australia, n = 42) with substance abuse disorder (n = 224), schizophrenia (n = 158), mood disorders (n = 227), and somatoform disorders (n = 63). The General Health Behaviour Questionnaire measured behaviors and knowledge related to nutrition, physical activity, alcohol, smoking, sleep, life satisfaction, and wellbeing. The normative samples were derived from a German population (N = 1,019). Data were analyzed using ANOVAs and t-tests.
   Results: The Palestine sample did not differ from the Western samples on reported life satisfaction and wellbeing. However, they reported unhealthier diets, less physical activity, and lower knowledge about the impact of diet, physical activity, smoking, and sleep on health than the Western samples. Comparing the Western and normative samples, people with mental illness reported lower intake of healthy foods/drinks, higher intake of unhealthy foods, higher exercise, higher alcohol consumption, less cigarettes, less sleep, and more sleep problems. Their knowledge was lower for nutrition, physical activity, and smoking. All participants reported lower life satisfaction and wellbeing than the normative sample (P-values <0.001).
   Conclusion: Education on health related lifestyle factors present important targets for primary care, quality of life and prevention of illness in people with mental illness. Further research will clarify specific predictors of health behaviors in each country.
C1 [Parletta, Natalie] Univ South Australia, Sch Hlth Sci, Ctr Populat Hlth Res, Adelaide, SA, Australia.
   [Aljeesh, Yousef] Islamic Univ Gaza, Fac Nursing, Gaza, Israel.
   [Baune, Bernhard T.] Univ Adelaide, Dept Psychiat, Adelaide, SA, Australia.
C3 University of South Australia; Islamic University Gaza; University of
   Adelaide
RP Baune, BT (corresponding author), Univ Adelaide, Dept Psychiat, Adelaide, SA, Australia.
EM bernhard.baune@adelaide.edu.au
RI Baune, Bernhard/JGD-5133-2023; Parletta, Natalie/A-7880-2008
OI Parletta, Natalie/0000-0003-2322-5555
CR [Anonymous], 2012, AUSTR HLTH SER
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NR 43
TC 31
Z9 36
U1 0
U2 29
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-0640
J9 FRONT PSYCHIATRY
JI Front. Psychiatry
PD AUG 22
PY 2016
VL 7
AR 145
DI 10.3389/fpsyt.2016.00145
PG 8
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA DT7PC
UT WOS:000381677700001
PM 27597833
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Poon, ETC
   Wongpipit, W
   Sun, FH
   Tse, ACY
   Sit, CHP
AF Poon, Eric Tsz-Chun
   Wongpipit, Waris
   Sun, Fenghua
   Tse, Andy Choi-Yeung
   Sit, Cindy Hui-Ping
TI High-intensity interval training in children and adolescents with
   special educational needs: a systematic review and narrative synthesis
SO INTERNATIONAL JOURNAL OF BEHAVIORAL NUTRITION AND PHYSICAL ACTIVITY
LA English
DT Review
DE HIIT; Interval exercise; Young people; Disabilities; Public health
ID PHYSICAL-ACTIVITY; CEREBRAL-PALSY; SEDENTARY TIME; MENTAL-HEALTH;
   EXERCISE; DISABILITIES; MODERATE; PEOPLE; RISK; PARTICIPATION
AB BackgroundHigh-intensity interval training (HIIT) has been promoted as a time-efficient exercise strategy to improve health and fitness in children and adolescents. However, there remains little consensus in the literature regarding its efficacy in children and adolescents with special educational needs (SEN). This study aimed to examine HIIT as a means of improving key health and fitness parameters in children and adolescents with SEN.MethodsA systematic search was conducted on eight databases (MEDLINE, Embase, SPORTDiscus, Web of Science, Scopus, PsycINFO, CINAHL, and Cochrane Library). Studies were eligible if they 1) included an HIIT protocol, 2) examined parameters related to both physical and mental aspects of health and fitness, and 3) examined children and adolescents with SEN aged 5-17 years.ResultsOf the 1727 studies yielded by the database search, 13 (453 participants) were included and reviewed. We found that HIIT generally improved body composition, physical fitness, and cardiometabolic risk biomarkers across a spectrum of SEN (e.g., attention deficit hyperactivity disorder, cerebral palsy, developmental coordination disorder, and mental illness). Improvements in mental health and cognitive performance following HIIT have also been observed.ConclusionThis review provides up-to-date evidence for HIIT as a viable exercise strategy for children and adolescents with SEN. Further research investigating the benefits of HIIT in a wider range of SEN populations is warranted.
C1 [Poon, Eric Tsz-Chun; Sun, Fenghua; Tse, Andy Choi-Yeung] Educ Univ Hong Kong, Dept Hlth & Phys Educ, Hong Kong, Peoples R China.
   [Wongpipit, Waris] Chulalongkorn Univ, Fac Educ, Div Hlth & Phys Educ, Bangkok, Thailand.
   [Wongpipit, Waris] Mahidol Univ, Inst Populat & Social Res, Thailand Phys Act Knowledge Dev Ctr, Nakhon Pathom, Thailand.
   [Sit, Cindy Hui-Ping] Chinese Univ Hong Kong, Dept Sports Sci & Phys Educ, Hong Kong, Peoples R China.
C3 Education University of Hong Kong (EdUHK); Chulalongkorn University;
   Mahidol University; Chinese University of Hong Kong
RP Wongpipit, W (corresponding author), Chulalongkorn Univ, Fac Educ, Div Hlth & Phys Educ, Bangkok, Thailand.; Wongpipit, W (corresponding author), Mahidol Univ, Inst Populat & Social Res, Thailand Phys Act Knowledge Dev Ctr, Nakhon Pathom, Thailand.
EM waris.w@chula.ac.th
RI Tse, Andy/AAF-7431-2020; Wongpipit, Waris/ACF-6667-2022; Sit,
   Cindy/AAY-1056-2020; SUN, Fenghua/N-4299-2014; Sit, Cindy/P-6770-2018
OI Poon, Eric Tsz-chun/0000-0002-0842-1323; TSE, Choi Yeung
   Andy/0000-0002-6187-9499; SUN, Fenghua/0000-0001-5251-4087; Wongpipit,
   Waris/0000-0002-0197-1357; Sit, Cindy/0000-0001-9992-7866
CR [Anonymous], 2021, ACSMs Guidelines for Exercise Testing and Prescription, V11th
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NR 56
TC 7
Z9 7
U1 3
U2 21
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1479-5868
J9 INT J BEHAV NUTR PHY
JI Int. J. Behav. Nutr. Phys. Act.
PD FEB 9
PY 2023
VL 20
IS 1
AR 13
DI 10.1186/s12966-023-01421-5
PG 14
WC Nutrition & Dietetics; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics; Physiology
GA 8T3NR
UT WOS:000929173700001
PM 36759853
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Dziegielewska-Gesiak, S
   Muc-Wierzgon, M
AF Dziegielewska-Gesiak, Sylwia
   Muc-Wierzgon, Malgorzata
TI Inflammation and Oxidative Stress in Frailty and Metabolic Syndromes-Two
   Sides of the Same Coin
SO METABOLITES
LA English
DT Review
DE metabolic syndrome; frailty syndrome; inflammatory markers;
   oxidant-antioxidant balance
ID OLDER-ADULTS; AGING-THEORIES; ASSOCIATION; HEALTHY; INTERVENTION;
   PREDICTORS; MECHANISMS; MORTALITY; EVOLUTION
AB In developed countries, aging is often seen as typical, but it is made complicated by many disorders and co-morbidities. Insulin resistance seems to be an underlying pathomechanism in frailty and metabolic syndromes. The decline in insulin sensitivity leads to changes in the oxidant-antioxidant balance and an accelerated inflammatory response, especially by adipocytes and macrophages in adipose tissue, as well as muscle mass density. Thus, in the pathophysiology of syndemic disorders-the metabolic syndrome and frailty syndrome-an extremely important role may be played by increased oxidative stress and pro-inflammatory state. Papers included in this review explored available full texts and the reference lists of relevant studies from the last 20 years, before the end of 2022; we also investigated the PubMed and Google Scholar electronic databases. The online resources describing an elderly population (>= 65 years old) published as full texts were searched for the following terms: "oxidative stress and/or inflammation", "frailty and/or metabolic syndrome". Then, all resources were analyzed and narratively described in the context of oxidative stress and/or inflammation markers which underlie pathomechanisms of frailty and/or metabolic syndromes in elderly patients. So far, different metabolic pathways discussed in this review show that a similar pathogenesis underlies the development of the metabolic as well as frailty syndromes in the context of increased oxidative stress and acceleration of inflammation. Thus, we argue that the syndemia of the syndromes represents two sides of the same coin.
C1 [Dziegielewska-Gesiak, Sylwia; Muc-Wierzgon, Malgorzata] Med Univ Silesia, Dept Internal Med Prevent, PL-40055 Katowice, Poland.
C3 Medical University of Silesia
RP Dziegielewska-Gesiak, S (corresponding author), Med Univ Silesia, Dept Internal Med Prevent, PL-40055 Katowice, Poland.
EM sgesiak@sum.edu.pl
RI Dzięgielewska-Gesiak, Sylwia/IYS-6186-2023
OI Muc-Wierzgon, Malgorzata/0000-0001-6562-7072; Dziegielewska-Gesiak,
   Sylwia/0000-0003-1019-5959
FU Medical University of Silesia [PCN-1-210/N/2/O]
FX This research was funded by Medical University of Silesia and is part of
   project No PCN-1-210/N/2/O.
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NR 111
TC 16
Z9 16
U1 2
U2 11
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2218-1989
J9 METABOLITES
JI Metabolites
PD APR
PY 2023
VL 13
IS 4
AR 475
DI 10.3390/metabo13040475
PG 13
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA E7AS1
UT WOS:000977033600001
PM 37110134
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU McCuen-Wurst, C
   Ruggieri, M
   Allison, KC
AF McCuen-Wurst, Courtney
   Ruggieri, Madelyn
   Allison, Kelly C.
TI Disordered eating and obesity: associations between binge-eating
   disorder, night-eating syndrome, and weight-related comorbidities
SO ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
LA English
DT Review
DE binge-eating disorder; night-eating syndrome; SSRI; cognitive behavior
   therapy; metabolic syndrome
ID BRIGHT LIGHT THERAPY; METABOLIC SYNDROME; PSYCHOLOGICAL TREATMENTS;
   RISK-FACTORS; PREVALENCE; SERTRALINE; ADULTS; TRIAL; PSYCHOPATHOLOGY;
   METAANALYSIS
AB Binge-eating disorder (BED) and night-eating syndrome (NES) are two forms of disordered eating associated with overweight and obesity. While these disorders also occur in nonobese persons, they seem to be associated with weight gain over time and higher risk of diabetes and other metabolic dysfunction. BED and NES are also associated with higher risk of psychopathology, including mood, anxiety, and sleep problems, than those of similar weight status without disordered eating. Treatments are available, including cognitive behavior therapy (CBT), interpersonal psychotherapy, lisdexamfetamine, and selective serotonin reuptake inhibitors (SSRIs) for BED; and CBT, SSRIs, progressive muscle relaxation, and bright light therapy for NES.
C1 [McCuen-Wurst, Courtney; Ruggieri, Madelyn; Allison, Kelly C.] Univ Penn, Dept Psychiat, Perelman Sch Med, 3535 Market St,Suite 3029, Philadelphia, PA 19104 USA.
C3 University of Pennsylvania
RP Allison, KC (corresponding author), Univ Penn, Dept Psychiat, Perelman Sch Med, 3535 Market St,Suite 3029, Philadelphia, PA 19104 USA.
EM kca@mail.med.upenn.edu
RI Allison, Kelly/O-4174-2019
OI Allison, Kelly/0000-0002-9807-0220
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NR 87
TC 240
Z9 263
U1 15
U2 156
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0077-8923
EI 1749-6632
J9 ANN NY ACAD SCI
JI Ann. N.Y. Acad. Sci.
PD JAN
PY 2018
VL 1411
IS 1
SI SI
BP 96
EP 105
DI 10.1111/nyas.13467
PG 10
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Science & Technology - Other Topics
GA FU0PE
UT WOS:000423552000007
PM 29044551
OA Green Accepted
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Conti, FF
   Brito, JD
   Bernardes, N
   Dias, DD
   Sanches, IC
   Malfitano, C
   Llesuy, SF
   Irigoyen, MC
   de Angelis, K
AF Conti, Filipe Fernandes
   Brito, Janaina de Oliveira
   Bernardes, Nathalia
   Dias, Danielle da Silva
   Sanches, Iris Callado
   Malfitano, Christiane
   Francisca Llesuy, Susana
   Irigoyen, Maria-Claudia
   de Angelis, Katia
TI Cardiovascular autonomic dysfunction and oxidative stress induced by
   fructose overload in an experimental model of hypertension and menopause
SO BMC CARDIOVASCULAR DISORDERS
LA English
DT Article
DE Menopause; Metabolic syndrome; Heart rate variability; Blood pressure
   variability; Inflammation; Oxidative stress
ID METABOLIC SYNDROME; BAROREFLEX SENSITIVITY; INSULIN-RESISTANCE;
   EXERCISE; STIMULATION; BENEFITS; OBESITY; RISK; MICE
AB Background: Metabolic syndrome is characterized by the association of 3 or more risk factors, including: abdominal obesity associated with an excess of abdominal fat, insulin resistance, type 2 diabetes, dyslipidemia and hypertension. Moreover, the prevalence of hypertension and metabolic dysfunctions sharply increases after the menopause. However, the mechanisms involved in these changes are not well understood. Thus, the aim of this study was to assess the effects of fructose overload on cardiovascular autonomic modulation, inflammation and cardiac oxidative stress in an experimental model of hypertension and menopause.
   Methods: Female SHR rats were divided into (n = 8/group): hypertensive (H), hypertensive ovariectomized (HO) and hypertensive ovariectomized undergoing fructose overload (100 g/L in drinking water) (FHO). Arterial pressure (AP) signals were directly recorded. Cardiac autonomic modulation was evaluated by spectral analysis. Oxidative stress was evaluated in cardiac tissue.
   Results: AP was higher in the FHO group when compared to the other groups. Fructose overload promoted an increase in body and fat weight, triglyceride concentration and a reduction in insulin sensitivity. IL-10 was reduced in the FHO group when compared to the H group. TNF-alpha was higher in the FHO when compared to all other groups. Lipoperoxidation was higher and glutathione redox balance was reduced in the FHO group when compared to other groups, an indication of increased oxidative stress. A negative correlation was found between IL-10 and adipose tissue.
   Conclusion: Fructose overload promoted an impairment in cardiac autonomic modulation associated with inflammation and oxidative stress in hypertensive rats undergoing ovarian hormone deprivation.
C1 [Conti, Filipe Fernandes; Brito, Janaina de Oliveira; Dias, Danielle da Silva; Sanches, Iris Callado; Malfitano, Christiane; de Angelis, Katia] Univ Nove de Julho UNINOVE, Lab Translat Physiol, Sao Paulo, Brazil.
   [Bernardes, Nathalia; Irigoyen, Maria-Claudia] Univ Sao Paulo, Heart Inst InCor, Sch Med, Hypertens Unit, Sao Paulo, Brazil.
   [Francisca Llesuy, Susana] Univ Buenos Aires, Fac Farm & Bioquim, Dept Quim Analit & Fisicoquim, RA-1113 Buenos Aires, DF, Argentina.
C3 Universidade Nove de Julho; Universidade de Sao Paulo; University of
   Buenos Aires
RP de Angelis, K (corresponding author), Univ Nove de Julho UNINOVE, Lab Translat Physiol, Sao Paulo, Brazil.
EM prof.kangelis@uninove.br
RI Bernardes, Nathalia/L-7460-2015; Conti, Filipe/C-3060-2013; Malfitano,
   Christiane/I-2701-2013; da Silva Dias, Danielle/AAN-7618-2020; Irigoyen,
   maria Claudia/N-6880-2014; DE ANGELIS, KATIA/I-6098-2016; Sanches, Iris
   Callado/D-5079-2013
OI Francisca Llesuy, Susana/0000-0001-6818-051X; Irigoyen, maria
   Claudia/0000-0003-2097-3662; DE ANGELIS, KATIA/0000-0002-3640-9049;
   Sanches, Iris Callado/0000-0001-6195-4340
FU CAPES (CAPES-DFAIT) [88881.062178/2014-01, 01/2013]; CNPq
   [479766/2011-8]; FAPESP [2012/20141-5, 2011/15828-9, 2010/17188-4]; CNPq
   Fellowship (CNPq-BPQ)
FX This study was supported by CAPES (88881.062178/2014-01; CAPES-DFAIT
   01/2013), CNPq (479766/2011-8) and FAPESP (2012/20141-5; 2011/15828-9;
   2010/17188-4). Maria-Claudia Irigoyen and Katia De Angelis are
   recipients of CNPq Fellowship (CNPq-BPQ).
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NR 33
TC 25
Z9 27
U1 0
U2 16
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1471-2261
J9 BMC CARDIOVASC DISOR
JI BMC Cardiovasc. Disord.
PD DEC 11
PY 2014
VL 14
AR 185
DI 10.1186/1471-2261-14-185
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA AY1IR
UT WOS:000347347700001
PM 25495455
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Wang, QZ
   Sun, YY
   Ma, AG
   Li, Y
   Han, XX
   Liang, H
AF Wang, Qiuzhen
   Sun, Yongye
   Ma, Aiguo
   Li, Yong
   Han, Xiuxia
   Liang, Hui
TI Effects of Vitamin E on Plasma Lipid Status and Oxidative Stress in
   Chinese Women with Metabolic Syndrome
SO INTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCH
LA English
DT Article
DE vitamin E; lipid; oxidative stress; hemolysis; metabolic syndrome
ID CORONARY-HEART-DISEASE; ALPHA-TOCOPHEROL; SUPEROXIDE-DISMUTASE;
   ANTIOXIDANT VITAMINS; E SUPPLEMENTATION; RISK; METAANALYSIS;
   CHOLESTEROL; SUPPRESSION
AB Following the change of dietary structure and living style, metabolic syndrome (MetS) has become increasingly common in China, especially in women, who have abnormal plasma lipid profiles with increased levels of oxidative stress. Vitamin E (VitE) is a powerful chain-breaking antioxidant, which may be a protective factor against oxidative stress-related diseases. This study investigated the effects of three different dosages of tocopherol supplementation (100 IU /day, 200 IU /day, 300 IU /day) for 4 months in Chinese women with MetS. The plasma VitE concentrations increased significantly after the 4 months of supplementation (p < 0.01). The protective decreases in plasma total cholesterol were significant in 200 IU/day and 300 IU/day VitE groups (p < 0.05), but decreases in high-density lipoprotein cholesterol were also significant in all the supplementation groups (p < 0.05). Plasma tri-glycerides were unaltered (p > 0.05). The indicators of oxidative stress decreased substantially in all of the VitE supplementation groups: malondialdehyde (MDA) was reduced by nearly 50 percent (all groups, p < 0.001), erythrocyte hemolysis was decreased by nearly 40 percent (all groups, p < 0.05); among which the 300IU/day VitE group showed the most significant effect. However, the activity of superoxide dismutase (SOD) decreased after the trial (p < 0.001). VitE provided marked benefits in reducing oxidative stress levels and improving lipid status in women with MetS. Although no dose-effect relationship was observed, 300 IU VitE per day showed the optimal effect. Research is needed to identify potential protective mechanisms or utilization of vitamin E during MetS.
C1 [Wang, Qiuzhen; Sun, Yongye; Ma, Aiguo; Li, Yong; Han, Xiuxia; Liang, Hui] Qingdao Univ, Coll Med, Inst Human Nutr, Qingdao 266021, Peoples R China.
C3 Qingdao University
RP Ma, AG (corresponding author), Qingdao Univ, Coll Med, Inst Human Nutr, 38 Dengzhou Rd, Qingdao 266021, Peoples R China.
EM kevin1971@yahoo.cn; aiguom502@hotmail.com
FU National Natural Science Foundation of China [30872103]; Chinese
   Nutrition Society
FX This research was supported by the National Natural Science Foundation
   of China, grant number 30872103, and Chinese Nutrition Society. We
   express our great gratitude to professors Zhang Xiuzhen and Wang Xin for
   measurements and technical assistance in laboratory work and epidemic
   spot research. The authors do not have any conflicts of interest with
   the funding agencies of this study.
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NR 34
TC 26
Z9 27
U1 0
U2 24
PU HOGREFE AG-HOGREFE AG SUISSE
PI BERN
PA LANGGASSSTRASSE 76, BERN, SWITZERLAND
SN 0300-9831
EI 1664-2821
J9 INT J VITAM NUTR RES
JI Int. J. Vitam. Nutr. Res.
PD JUN
PY 2010
VL 80
IS 3
BP 178
EP 187
DI 10.1024/0300-9831/a000015
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 721EN
UT WOS:000287336500003
PM 21234859
DA 2025-06-11
ER

PT J
AU Zhang, JW
   Lv, WQ
   Zhang, GF
   Zeng, MQ
   Cao, WL
   Su, JC
   Cao, K
   Liu, JK
AF Zhang, Jiawei
   Lv, Weiqiang
   Zhang, Guanfei
   Zeng, Mengqi
   Cao, Wenli
   Su, Jiacan
   Cao, Ke
   Liu, Jiankang
TI Nuclear Factor Erythroid 2 Related Factor 2 and Mitochondria Form
   a Mutually Regulating Circuit in the Prevention and Treatment of
   Metabolic Syndrome
SO ANTIOXIDANTS & REDOX SIGNALING
LA English
DT Article
DE Nrf2; mitochondria; metabolic syndrome; oxidative stress; inflammation
ID HIGH-FAT DIET; PIGMENT EPITHELIAL-CELLS; TYPE-2 DIABETIC-PATIENTS;
   PHASE-II ENZYMES; OXIDATIVE STRESS; INSULIN-RESISTANCE; HEME
   OXYGENASE-1; NRF2 ACTIVATION; INDUCED OBESITY; UP-REGULATION
AB Significance: Metabolic syndrome (MetS) has become a major global public health problem and there is an urgent need to elucidate its pathogenesis and find more effective targets and modalities for intervention. Recent Advances: Oxidative stress and inflammation are two of the major causes of MetS-related symptoms such as insulin resistance and obesity. Nuclear factor erythroid 2 related factor 2 (Nrf2) is one of the important systems responding to oxidative stress and inflammation. As cells undergo stress, cysteines within Kelch-like ECH-associated protein 1 (Keap1) are oxidized or electrophilically modified, allowing Nrf2 to escape ubiquitination and be translocated from the cytoplasm to the nucleus, facilitating the initiation of the antioxidant transcriptional program. Meanwhile, a growing body of evidence points out a specific modulation of mitochondrial homeostasis by Nrf2. After nuclear translocation, Nrf2 activates downstream genes involved in various aspects of mitochondrial homeostasis, including mitochondrial biogenesis and dynamics, mitophagy, aerobic respiration, and energy metabolism. In turn, mitochondria reciprocally activate Nrf2 by releasing reactive oxygen species and regulating antioxidant enzymes. Critical Issues: In this review, we first summarize the interactions between Nrf2 and mitochondria in the modulation of oxidative stress and inflammation to ameliorate MetS, then propose that Nrf2 and mitochondria form a mutually regulating circuit critical to maintaining homeostasis during MetS. Future Directions: Targeting the Nrf2-mitochondrial circuit may be a promising strategy to ameliorate MetS, such as obesity, diabetes, and cardiovascular diseases.
C1 [Zhang, Jiawei; Lv, Weiqiang; Zhang, Guanfei; Zeng, Mengqi; Cao, Wenli; Cao, Ke; Liu, Jiankang] Xi An Jiao Tong Univ, Sch Life Sci & Technol, Ctr Mitochondrial Biol & Med, Key Lab Biomed Informat Engn,Minist Educ, Xian, Peoples R China.
   [Su, Jiacan] Naval Mil Med Univ, Shanghai Changhai Hosp, Dept Orthoped Trauma, Shanghai, Peoples R China.
   [Liu, Jiankang] Univ Hlth & Rehabil Sci, Sch Hlth & Life Sci, Qingdao, Peoples R China.
   [Cao, Ke; Liu, Jiankang] Xi An Jiao Tong Univ, Ctr Mitochondrial Biol & Med, Sch Life Sci & Technol, Key Lab Biomed Informat Engn,Minist Educ, Xian 710049, Peoples R China.
C3 Ministry of Education - China; Xi'an Jiaotong University; Naval Medical
   University; University of Health & Rehabilitation Sciences; Ministry of
   Education - China; Xi'an Jiaotong University
RP Cao, K; Liu, JK (corresponding author), Xi An Jiao Tong Univ, Ctr Mitochondrial Biol & Med, Sch Life Sci & Technol, Key Lab Biomed Informat Engn,Minist Educ, Xian 710049, Peoples R China.
EM caoke2016@mail.xjtu.edu.cn; jkliu@uor.edu.cn
RI Zhang, Jiawei/JQJ-1625-2023
OI Liu, Jiankang/0000-0003-1207-5037
FU Integrated Project of Major Research Plan of National Natural Science
   Foundation of China [92249303]; General Projects of National Natural
   Science Foundation of China [32171102, 31770917, 82271727]; Natural
   Science Basic Research Program of Shaanxi Province [2022JQ-767]
FX This work was funded by the Integrated Project of Major Research Plan of
   National Natural Science Foundation of China 92249303 ( Jiankang Liu and
   Jiacan Su), the General Projects of National Natural Science Foundation
   of China 32171102 and 31770917 ( Jiankang Liu) and 82271727(Ke Cao), and
   the Natural Science Basic Research Program of Shaanxi Province
   2022JQ-767 (Ke Cao).
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NR 249
TC 7
Z9 7
U1 10
U2 23
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1523-0864
EI 1557-7716
J9 ANTIOXID REDOX SIGN
JI Antioxid. Redox Signal.
PD OCT 1
PY 2024
VL 41
IS 10-12
BP 744
EP 768
DI 10.1089/ars.2023.0339
EA MAR 2024
PG 25
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA J9P8I
UT WOS:001188644500001
PM 38183629
DA 2025-06-11
ER

PT S
AU Abraham, NG
   Brunner, EJ
   Eriksson, JW
   Robertson, RP
AF Abraham, N. G.
   Brunner, E. J.
   Eriksson, J. W.
   Robertson, R. P.
BE Csermely, P
   Korcsmaros, T
   Sulyok, K
TI Metabolic syndrome: Psychosocial, neuroendocrine, and classical risk
   factors in type 2 diabetes
SO STRESS RESPONSES IN BIOLOGY AND MEDICINE: STRESS OF LIFE IN MOLECULES,
   CELLS, ORGANISMS, AND PSYCHOSOCIAL COMMUNITIES
SE Annals of the New York Academy of Sciences
LA English
DT Article; Proceedings Paper
CT 2nd World Conference on Stress
CY AUG 23-26, 2007
CL Budapest, HUNGARY
DE work stress; social epidemiology; neuroendocrine; adipokines; insulin
   resistance; antioxidants; adipocyte; glutathione cell; bilirubin
ID PANCREATIC BETA-CELLS; HIGH GLUCOSE-CONCENTRATIONS; INSULIN
   GENE-TRANSCRIPTION; AUTONOMIC NERVOUS-SYSTEM; HEART-RATE-VARIABILITY;
   GLUCOTOXICITY IN-VIVO; WORK STRESS; OXIDATIVE STRESS; WHITEHALL-II;
   RESISTANT SUBJECTS
AB This article summarizes some aspects of stress in the metabolic syndrome at the psychosocial, tissue, and cellular levels. The metabolic svndrome is a valuable research concept for studying population heaith and social-biological translation. The cluster of cardiovascular risk factors labeled the metabolic syndrome is linked with low socioeconomic status. Systematic differences in diet and physical activity contribute to social patterning of the syndrome. In addition, psychosocial factors including chronic work stress are linked with its development. Psychosocial factors could lead to metabolic perturbations and increase cardiovascular risk via activation of neuroendocrine responses, for example, in the autonomic nervous system and in several hormonal pathways. High glucocorticoid levels will promote lipid storage in visceral rather than subcutaneous adipose tissue. Adipocytes secrete several proinflammatory cytokines, which considered major contributors to increase in oxidants and cell injury. Upregulation of heme oxygenase 1 (HO-1) and peroxidase in the early development of diabetes produces a decrease in oxidative-mediated injury. Increased HO activity is associated with a significant decrease in superoxide, endothelial cell shedding and blood pressure. Finally, it is proposed that overexpression of glutathione peroxidase in beta cells may protect beta cell deterioration from oxidative stress during development of diabetes and hyperglycemia and this may result in attenuation of beta cell failure. If this proves to be the case, then the scene will be set to develop glutathione peroxidase mimetics for use in preclinical and clinical trials.
C1 New York Med Coll, Dept Pharmacol, Valhalla, NY 10595 USA.
   UCL, London WC1E 6BT, England.
   Sahlgrens Univ Hosp, Gothenburg, Sweden.
   Univ Washington, Seattle, WA 98195 USA.
C3 New York Medical College; University of London; University College
   London; Sahlgrenska University Hospital; University of Washington;
   University of Washington Seattle
RP Abraham, NG (corresponding author), New York Med Coll, Dept Pharmacol, Basis Sci Bldg Room 527, Valhalla, NY 10595 USA.
EM nader_abraham@nymc.edu
RI Roberston, R/AAX-5613-2021; Eriksson, Jan/AAB-5820-2021; Brunner,
   Eric/H-2114-2011
OI Brunner, Eric/0000-0002-0595-4474
FU NHLBI NIH HHS [HL34300, HL55601] Funding Source: Medline; NIDDK NIH HHS
   [DK-38325, DK068134] Funding Source: Medline
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NR 52
TC 35
Z9 42
U1 0
U2 10
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN STREET, MALDEN 02148, MA USA
SN 0077-8923
BN 978-1-57331-675-0
J9 ANN NY ACAD SCI
JI Ann.NY Acad.Sci.
PY 2007
VL 1113
BP 256
EP 275
DI 10.1196/annals.1391.015
PG 20
WC Psychology, Biological; Behavioral Sciences; Biochemistry & Molecular
   Biology; Immunology; Multidisciplinary Sciences; Psychology, Social
WE Conference Proceedings Citation Index - Science (CPCI-S); Conference Proceedings Citation Index - Social Science &amp; Humanities (CPCI-SSH); Science Citation Index Expanded (SCI-EXPANDED)
SC Psychology; Behavioral Sciences; Biochemistry & Molecular Biology;
   Immunology; Science & Technology - Other Topics
GA BGX56
UT WOS:000251158200022
PM 17513461
DA 2025-06-11
ER

PT J
AU Storz, MA
AF Storz, Maximilian Andreas
TI Lifestyle Adjustments in Long-COVID Management: Potential Benefits of
   Plant-Based Diets
SO CURRENT NUTRITION REPORTS
LA English
DT Article
DE SARS-CoV-2; Long-COVID; Plant-based diet; Vegan; Nutrition; Economic
   burden
ID QUALITY-OF-LIFE; SLEEP QUALITY; VEGETABLE CONSUMPTION; DEPRESSIVE
   SYMPTOMS; METABOLIC SYNDROME; VEGAN DIET; LOW-FAT; TRYPTOPHAN; PATTERN;
   ANXIETY
AB Purpose of Review The SARS-CoV-2-pandemic has caused mortality and morbidity at an unprecedented global scale. Many patients infected with SARS-CoV-2 continue to experience symptoms after the acute phase of infection and report fatigue, sleep difficulties, anxiety, and depression as well as arthralgia and muscle weakness. Summarized under the umbrella term "long-COVID," these symptoms may last weeks to months and impose a substantial burden on affected individuals. Dietary approaches to tackle these complications have received comparably little attention. Although plant-based diets in particular were shown to exert benefits on underlying conditions linked to poor COVID-19 outcomes, their role with regard to COVID-19 sequelae is yet largely unknown. Thus, this review sought to investigate whether a plant-based diet could reduce the burden of long-COVID. Recent Findings The number of clinical trials investigating the role of plant-based nutrition in COVID-19 prevention and management is currently limited. Yet, there is evidence from pre-pandemic observational and clinical studies that a plant-based diet may be of general benefit with regard to several clinical conditions that can also be found in individuals with COVID-19. These include anxiety, depression, sleep disorders, and musculoskeletal pain. Adoption of a plant-based diet leads to a reduced intake in pro-inflammatory mediators and could be one accessible strategy to tackle long-COVID associated prolonged systemic inflammation. Summary Plant-based diets may be of general benefit with regard to some of the most commonly found COVID-19 sequelae. Additional trials investigating which plant-based eating patterns confer the greatest benefit in the battle against long-COVID are urgently warranted.
C1 [Storz, Maximilian Andreas] Univ Freiburg, Inst Infect Prevent & Hosp Epidemiol, Fac Med, Ctr Complementary Med, Freiburg, Germany.
C3 University of Freiburg
RP Storz, MA (corresponding author), Univ Freiburg, Inst Infect Prevent & Hosp Epidemiol, Fac Med, Ctr Complementary Med, Freiburg, Germany.
EM maximilian.storz@uniklinik-freiburg.de
RI Storz, Maximilian/GLR-8109-2022
OI Storz, Maximilian Andreas/0000-0003-3277-0301
FU Projekt DEAL
FX Open Access funding enabled and organized by Projekt DEAL.
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NR 157
TC 27
Z9 28
U1 0
U2 40
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
EI 2161-3311
J9 CURR NUTR REP
JI Curr. Nutr. Rep.
PD DEC
PY 2021
VL 10
IS 4
BP 352
EP 363
DI 10.1007/s13668-021-00369-x
EA SEP 2021
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nutrition & Dietetics
GA XY1DS
UT WOS:000694774300001
PM 34506003
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Chung, HK
   Kim, JH
   Choi, A
   Ahn, CW
   Kim, YS
   Nam, JS
AF Chung, Hye-Kyung
   Kim, Jung Hye
   Choi, Arim
   Ahn, Chul Woo
   Kim, Yu-Sik
   Nam, Ji Sun
TI Antioxidant-Rich Dietary Intervention Improves Cardiometabolic Profiles
   and Arterial Stiffness in Elderly Koreans with Metabolic Syndrome
SO YONSEI MEDICAL JOURNAL
LA English
DT Article
DE Diet therapy; oxidative stress; metabolic syndrome; vascular stiffness
ID OXIDATIVE STRESS; INSULIN-RESISTANCE; DOUBLE-BLIND; VITAMIN-E;
   VEGETABLES; FRUIT; RISK; CONSUMPTION; PREVENTION; SUPPLEMENTATION
AB Purpose: Oxidative stress plays an important role in the pathogenesis of chronic metabolic diseases. This study investigated the effect of the antioxidant-rich dietary intervention on oxidative stress, metabolic parameters, and arterial stiffness in elderly Koreans with metabolic syndrome (MetS). Materials and Methods: Thirty-one subjects with MetS were enrolled and randomly divided into dietary intervention group and control group. Subjects in the intervention group received three meal boxes prepared with antioxidant-rich ingredients every day for 4 weeks, and subjects in the control group maintained their usual diets. Anthropometric and various biochemical parameters related to oxidative stress, inflammation, and MetS were assessed. Brachial-ankle pulse wave velocity (baPWV) and fat measurement using computed tomography were also conducted before and after 4 weeks. Results: There were significant differences in waist circumference, visceral to subcutaneous fat ratio, lipid peroxidation, oxidized low density lipoprotein (oxLDL), systolic and diastolic blood pressure, lipid parameters, advanced glycation end products, and baPWV between before and after the study in the experimental group (all p<0.05). Significant inter-group differences were observed between the experimental and control group in terms of the differences in body mass index, waist circumference, oxygen radical absorbance capacity, protein carboxylation, lipid peroxidation, oxLDL, blood pressure, lipid parameters, and baPWV between before and after the study (all p<0.05). Conclusion: Antioxidant-rich dietary intervention for a 4-week period ameliorated the state of oxidative stress and improved the components of MetS including central obesity, dyslipidemia, hypertension, and arterial stiffness in elderly Koreans with MetS.
C1 [Chung, Hye-Kyung; Ahn, Chul Woo; Kim, Yu-Sik; Nam, Ji Sun] Yonsei Univ, Coll Med, Severance Inst Vasc & Metab Res, 50-1 Yonsei Ro, Seoul 03722, South Korea.
   [Kim, Jung Hye; Choi, Arim; Ahn, Chul Woo; Nam, Ji Sun] Yonsei Univ, Gangnarn Severance Hosp, Dept Internal Med, Div Endocrinol,Coll Med, 211 Eonju Ro, Seoul 06273, South Korea.
C3 Yonsei University; Yonsei University Health System; Yonsei University;
   Yonsei University Health System
RP Kim, YS (corresponding author), Yonsei Univ, Coll Med, Severance Inst Vasc & Metab Res, 50-1 Yonsei Ro, Seoul 03722, South Korea.; Nam, JS (corresponding author), Yonsei Univ, Gangnarn Severance Hosp, Dept Internal Med, Div Endocrinol,Coll Med, 211 Eonju Ro, Seoul 06273, South Korea.
EM cromoton@yuhs.ac; jisunn@yuhs.ac
RI Kim, YuSik/HZI-5757-2023
OI Nam, Ji Sun/0000-0001-8655-5258; Kim, Jung Hye/0000-0003-1427-5729; Kim,
   Yu Sik/0000-0002-2921-6433; Ahn, Chul Woo/0000-0003-3733-7486
FU Food Research Institute, OURHOME Co., Ltd.
FX This work was supported by the Food Research Institute, OURHOME Co.,
   Ltd.
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NR 42
TC 14
Z9 15
U1 0
U2 5
PU YONSEI UNIV COLL MEDICINE
PI SEOUL
PA 50-1 YONSEI-RO, SEODAEMUN-GU, SEOUL 120-752, SOUTH KOREA
SN 0513-5796
EI 1976-2437
J9 YONSEI MED J
JI Yonsei Med. J.
PD JAN
PY 2022
VL 63
IS 1
BP 26
EP 33
DI 10.3349/ymj.2022.63.1.26
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA XT5KU
UT WOS:000733627200004
PM 34913281
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Arévalo, SP
   Tucker, KL
   Falcón, LM
AF Arevalo, Sandra P.
   Tucker, Katherine L.
   Falcon, Luis M.
TI Life events trajectories, allostatic load, and the moderating role of
   age at arrival from Puerto Rico to the US mainland
SO SOCIAL SCIENCE & MEDICINE
LA English
DT Article
DE Stressful life events; Stress trajectories; Age at arrival; Migration
   related stress; Allostatic load; Latinos/hispanics; Puerto Rican
   migrants
ID ADVERSE CHILDHOOD EXPERIENCES; DEPRESSIVE SYMPTOMS; METABOLIC SYNDROME;
   SOCIAL SUPPORT; MENTAL-HEALTH; IMMIGRATION; STRESS; ACCULTURATION;
   MIGRATION; RISK
AB Our aim was to examine the effects of trajectories of stressful life events on allostatic load, measured over a two year time period, and to investigate the roles of language acculturation and age at migration in this association, in a sample of Puerto Rican migrants. We used data from the Boston Puerto Rican Health Study; a population-based prospective cohort of older Puerto Ricans recruited between the ages of 45 and 75 years. The Institutional Review Boards at Tufts Medical Center and Northeastern University approved the study. We used latent growth mixture modeling (LGMM) to identify different classes of two-year trajectories of stressful life events; analysis of variance to examine group differences by stress trajectory; and linear regression to test for the modifying effects of age at arrival on the association of stress trajectory with allostatic load at follow-up. In LGMM analysis, we identified three distinct stress trajectories; low, moderate ascending, and high. Unexpectedly, participants in the low stress group had the highest allostatic load at follow-up (F = 4.4, p = 0.01) relative to the other two groups. Age at arrival had a statistically significant moderating effect on the association. A reported two year period of moderate but repetitive and increasingly bad life events was associated with increases in allostatic load for participants who arrived to the U.S. mainland after the age of 5 years, and was particularly strong for those arriving between 6 and 11 years, but not for those arriving earlier or later. Results from this study highlight the complex effects of stress during the life course, and point to certain vulnerable periods for immigrant children that could modify long term effects of stress. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Arevalo, Sandra P.; Tucker, Katherine L.] Univ Massachusetts, Coll Hlth Sci Clin Lab & Nutr Sci, Lowell, MA 01854 USA.
   [Falcon, Luis M.] Univ Massachusetts, Coll Fine Arts Humanities & Social Sci, Lowell, MA 01854 USA.
C3 University of Massachusetts System; University of Massachusetts Lowell;
   University of Massachusetts System; University of Massachusetts Lowell
RP Arévalo, SP (corresponding author), Univ Massachusetts, Coll Hlth Sci Clin Lab & Nutr Sci, 3 Solomont Way,Suite 4,Weed Hall, Lowell, MA 01854 USA.
EM sandra.pag@gmail.com
RI Falcon, Luis/C-1237-2009; Arevalo, Sandra/AAC-3815-2020; Tucker,
   Katherine/A-4545-2010
OI Falcon, Luis M./0000-0002-2476-5046; Arevalo, Sandra
   P./0000-0002-5215-4971; Tucker, Katherine/0000-0001-7640-662X
FU National Institute on Aging [P01 AG023394]; National Heart, Lung, and
   Blood Institute [P50 HL105185]
FX This study was funded by the National Institute on Aging (P01 AG023394)
   and National Heart, Lung, and Blood Institute (P50 HL105185). The
   assistance of our field staff, data management team, and community
   members who participated in the study is gratefully acknowledged.
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NR 81
TC 19
Z9 25
U1 3
U2 27
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0277-9536
J9 SOC SCI MED
JI Soc. Sci. Med.
PD NOV
PY 2014
VL 120
BP 301
EP 310
DI 10.1016/j.socscimed.2014.09.040
PG 10
WC Public, Environmental & Occupational Health; Social Sciences, Biomedical
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; Biomedical Social Sciences
GA AT8JU
UT WOS:000345180600034
PM 25265208
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Pourriyahi, H
   Yazdanpanah, N
   Saghazadeh, A
   Rezaei, N
AF Pourriyahi, Homa
   Yazdanpanah, Niloufar
   Saghazadeh, Amene
   Rezaei, Nima
TI Loneliness: An Immunometabolic Syndrome
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Review
DE loneliness; perceived social isolation; psychosocial stress; CTRA;
   immune regulation; cytokines; antiviral immunity; metabolic regulation;
   stress circuitry; hypothalamic-pituitary-adrenocortical axis; cortisol
ID MIGRATION INHIBITORY FACTOR; SOCIAL-ISOLATION; GENE-EXPRESSION;
   ENDOGENOUS OPIOIDS; RISK-FACTORS; GLUCOCORTICOID REGULATION; LEUKOCYTE
   TRANSCRIPTOME; INFLAMMATORY RESPONSES; DEPRESSIVE SYMPTOMS; PSYCHOSOCIAL
   STRESS
AB Loneliness has been defined as an agonizing encounter, experienced when the need for human intimacy is not met adequately, or when a person's social network does not match their preference, either in number or attributes. This definition helps us realize that the cause of loneliness is not merely being alone, but rather not being in the company we desire. With loneliness being introduced as a measurable, distinct psychological experience, it has been found to be associated with poor health behaviors, heightened stress response, and inadequate physiological repairing activity. With these three major pathways of pathogenesis, loneliness can do much harm; as it impacts both immune and metabolic regulation, altering the levels of inflammatory cytokines, growth factors, acute-phase reactants, chemokines, immunoglobulins, antibody response against viruses and vaccines, and immune cell activity; and affecting stress circuitry, glycemic control, lipid metabolism, body composition, metabolic syndrome, cardiovascular function, cognitive function and mental health, respectively. Taken together, there are too many immunologic and metabolic manifestations associated with the construct of loneliness, and with previous literature showcasing loneliness as a distinct psychological experience and a health determinant, we propose that loneliness, in and of itself, is not just a psychosocial phenomenon. It is also an all-encompassing complex of systemic alterations that occur with it, expanding it into a syndrome of events, linked through a shared network of immunometabolic pathology. This review aims to portray a detailed picture of loneliness as an "immunometabolic syndrome ", with its multifaceted pathology.
C1 [Pourriyahi, Homa] Iran Univ Med Sci, Sch Med, Student Res Comm, Tehran 1449614535, Iran.
   [Pourriyahi, Homa] Universal Sci Educ & Res Network USERN, Systemat Review & Metaanal Expert Grp SRMEG, Tehran 1419733151, Iran.
   [Yazdanpanah, Niloufar] Univ Tehran Med Sci, Sch Med, Tehran 1416753955, Iran.
   [Yazdanpanah, Niloufar; Rezaei, Nima] Universal Sci Educ & Res Network USERN, Network Immun Infect Malignancy & Autoimmun NIIMA, Tehran 1419733151, Iran.
   [Saghazadeh, Amene; Rezaei, Nima] Univ Tehran Med Sci, Res Ctr Immunodeficiencies, Childrens Med Ctr, Tehran 1419733151, Iran.
   [Saghazadeh, Amene] Universal Sci Educ & Res Network USERN, MetaCognit Interest Grp MCIG, Tehran 1419733151, Iran.
   [Rezaei, Nima] Univ Tehran Med Sci, Sch Med, Dept Immunol, Tehran 1416753955, Iran.
C3 Iran University of Medical Sciences; Universal Scientific Education &
   Research Network (USERN); Tehran University of Medical Sciences;
   Universal Scientific Education & Research Network (USERN); Tehran
   University of Medical Sciences; Universal Scientific Education &
   Research Network (USERN); Tehran University of Medical Sciences
RP Rezaei, N (corresponding author), Universal Sci Educ & Res Network USERN, Network Immun Infect Malignancy & Autoimmun NIIMA, Tehran 1419733151, Iran.; Rezaei, N (corresponding author), Univ Tehran Med Sci, Res Ctr Immunodeficiencies, Childrens Med Ctr, Tehran 1419733151, Iran.; Rezaei, N (corresponding author), Univ Tehran Med Sci, Sch Med, Dept Immunol, Tehran 1416753955, Iran.
EM homapou99@gmail.com; yazdanpanah.niloufar@yahoo.com;
   amene.saghazadeh@gmail.com; rezaei_nima@tums.ac.ir
RI Rezaei, Navid/AAF-9880-2019; Yazdanpanah, Niloufar/JEZ-8740-2023;
   Rezaei, Nima/B-4245-2008
OI Saghazadeh, Amene/0000-0002-0945-8443; Rezaei, Nima/0000-0002-3836-1827;
   Yazdanpanah, Niloufar/0000-0003-4333-2163; Pourriyahi,
   Homa/0000-0001-5393-0875
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NR 197
TC 31
Z9 32
U1 5
U2 30
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD NOV
PY 2021
VL 18
IS 22
AR 12162
DI 10.3390/ijerph182212162
PG 24
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA XK2KK
UT WOS:000727300400001
PM 34831917
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Womersley, JS
   Nothling, J
   Toikumo, S
   Malan-Muller, S
   van den Heuvel, LL
   McGregor, NW
   Seedat, S
   Hemmings, SMJ
AF Womersley, Jacqueline S.
   Nothling, Jani
   Toikumo, Sylvanus
   Malan-Muller, Stefanie
   van den Heuvel, Leigh L.
   McGregor, Nathaniel W.
   Seedat, Soraya
   Hemmings, Sian M. J.
TI Childhood trauma, the stress response and metabolic syndrome: A focus on
   DNA methylation
SO EUROPEAN JOURNAL OF NEUROSCIENCE
LA English
DT Review
DE childhood trauma; epigenetics; hypothalamic-pituitary-adrenal axis;
   metabolic syndrome; methylation; stress response
ID GLUCOCORTICOID-RECEPTOR GENE; NEUROTROPHIC FACTOR BDNF; VISCERAL
   ADIPOSE-TISSUE; MESSENGER-RNA EXPRESSION; NECROSIS-FACTOR-ALPHA; OBESE
   MEN DISCORDANT; EARLY-LIFE STRESS; BORDERLINE PERSONALITY; EPIGENETIC
   MECHANISMS; UP-REGULATION
AB Childhood trauma (CT) is well established as a potent risk factor for the development of mental disorders. However, the potential of adverse early experiences to exert chronic and profound effects on physical health, including aberrant metabolic phenotypes, has only been more recently explored. Among these consequences is metabolic syndrome (MetS), which is characterised by at least three of five related cardiometabolic traits: hypertension, insulin resistance/hyperglycaemia, raised triglycerides, low high-density lipoprotein and central obesity. The deleterious effects of CT on health outcomes may be partially attributable to dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis, which coordinates the response to stress, and the consequent fostering of a pro-inflammatory environment. Epigenetic tags, such as DNA methylation, which are sensitive to environmental influences provide a means whereby the effects of CT can be biologically embedded and persist into adulthood to affect health and well-being. The methylome regulates the transcription of genes involved in the stress response, metabolism and inflammation. This narrative review examines the evidence for DNA methylation in CT and MetS in order to identify shared neuroendocrine and immune correlates that may mediate the increased risk of MetS following CT exposure. Our review specifically highlights differential methylation of FKBP5, the gene that encodes FK506-binding protein 51 and has pleiotropic effects on stress responding, inflammation and energy metabolism, as a central candidate to understand the molecular aetiology underlying CT-associated MetS risk.
C1 [Womersley, Jacqueline S.; Nothling, Jani; Toikumo, Sylvanus; Malan-Muller, Stefanie; van den Heuvel, Leigh L.; Seedat, Soraya; Hemmings, Sian M. J.] Stellenbosch Univ, Fac Med & Hlth Sci, Dept Psychiat, Cape Town, South Africa.
   [Womersley, Jacqueline S.; Nothling, Jani; van den Heuvel, Leigh L.; Seedat, Soraya; Hemmings, Sian M. J.] Stellenbosch Univ, Fac Med & Hlth Sci, Genom Brain Disorders Res Unit, South African Med Res Council, Cape Town, South Africa.
   [Nothling, Jani] South African Med Res Council, Gender & Hlth Res Unit, Cape Town, South Africa.
   [McGregor, Nathaniel W.] Stellenbosch Univ, Fac Agr, Dept Genet, Syst Genet Working Grp, Stellenbosch, South Africa.
C3 Stellenbosch University; Stellenbosch University; South African Medical
   Research Council; South African Medical Research Council; Stellenbosch
   University
RP Womersley, JS (corresponding author), Stellenbosch Univ, Fac Med & Hlth Sci, Dept Psychiat, Cape Town, South Africa.
EM jsw1@sun.ac.za
RI Hemmings, Sian/ABF-9676-2022; Womersley, Jacqueline/AAD-9579-2019; van
   den Heuvel, Leigh/AGV-5481-2022; Nöthling, Jani/ACT-7530-2022; McGregor,
   Nathaniel/H-7761-2015
OI Womersley, Jacqueline/0000-0001-9731-4505; McGregor,
   Nathaniel/0000-0001-7195-4993; Toikumo, Sylvanus/0000-0002-6024-0693;
   Seedat, Soraya/0000-0002-5118-786X; van den Heuvel,
   Leigh/0000-0003-3884-4754
FU South African Medical Research Council (SAMRC) [MRC-RFA-IFSP-01-2013]
FX South African Medical Research Council (SAMRC), Grant/Award Number:
   MRC-RFA-IFSP-01-2013
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NR 267
TC 30
Z9 32
U1 2
U2 21
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0953-816X
EI 1460-9568
J9 EUR J NEUROSCI
JI Eur. J. Neurosci.
PD MAY
PY 2022
VL 55
IS 9-10
SI SI
BP 2253
EP 2296
DI 10.1111/ejn.15370
EA JUL 2021
PG 44
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 1N4HX
UT WOS:000669689100001
PM 34169602
DA 2025-06-11
ER

PT J
AU Quagliariello, V
   Rossetti, S
   Cavaliere, C
   Di Palo, R
   Lamantia, E
   Castaldo, L
   Nocerino, F
   Ametrano, G
   Cappuccio, F
   Malzone, G
   Montanari, M
   Vanacore, D
   Romano, FJ
   Piscitelli, R
   Iovane, G
   Pepe, MF
   Berretta, M
   D'Aniello, C
   Perdonà, S
   Muto, P
   Botti, G
   Ciliberto, G
   Veneziani, BM
   De Falco, F
   Maiolino, P
   Caraglia, M
   Montella, M
   Iaffaioli, RV
   Facchini, G
AF Quagliariello, Vincenzo
   Rossetti, Sabrina
   Cavaliere, Carla
   Di Palo, Rossella
   Lamantia, Elvira
   Castaldo, Luigi
   Nocerino, Flavia
   Ametrano, Gianluca
   Cappuccio, Francesca
   Malzone, Gabriella
   Montanari, Micaela
   Vanacore, Daniela
   Romano, Francesco Jacopo
   Piscitelli, Raffaele
   Iovane, Gelsomina
   Pepe, Maria Filomena
   Berretta, Massimiliano
   D'Aniello, Carmine
   Perdona, Sisto
   Muto, Paolo
   Botti, Gerardo
   Ciliberto, Gennaro
   Veneziani, Bianca Maria
   De Falco, Francesco
   Maiolino, Piera
   Caraglia, Michele
   Montella, Maurizio
   Iaffaioli, Rosario Vincenzo
   Facchini, Gaetano
TI Metabolic syndrome, endocrine disruptors and prostate cancer
   associations: biochemical and pathophysiological evidences
SO ONCOTARGET
LA English
DT Review
DE metabolic syndrome; endocrine disruptors; prostate; cancer; nutrition
ID FACTOR-KAPPA-B; BISPHENOL-A; CELL-PROLIFERATION; OXIDATIVE STRESS; BROWN
   RICE; RISK; GROWTH; INTERLEUKIN-6; METAANALYSIS; ADIPONECTIN
AB This review summarizes the main pathophysiological basis of the relationship between metabolic syndrome, endocrine disruptor exposure and prostate cancer that is the most common cancer among men in industrialized countries. Metabolic syndrome is a cluster of metabolic and hormonal factors having a central role in the initiation and recurrence of many western chronic diseases including hormonal-related cancers and it is considered as the world's leading health problem in the coming years. Many biological factors correlate metabolic syndrome to prostate cancer and this review is aimed to focus, principally, on growth factors, cytokines, adipokines, central obesity, endocrine abnormalities and exposure to specific endocrine disruptors, a cluster of chemicals, to which we are daily exposed, with a hormone-like structure influencing oncogenes, tumor suppressors and proteins with a key role in metabolism, cell survival and chemo-resistance of prostate cancer cells. Finally, this review will analyze, from a molecular point of view, how specific foods could reduce the relative risk of incidence and recurrence of prostate cancer or inhibit the biological effects of endocrine disruptors on prostate cancer cells. On the basis of these considerations, prostate cancer remains a great health problem in terms of incidence and prevalence and interventional studies based on the treatment of metabolic syndrome in cancer patients, minimizing exposure to endocrine disruptors, could be a key point in the overall management of this disease.
C1 [Quagliariello, Vincenzo; Rossetti, Sabrina; Cavaliere, Carla; Di Palo, Rossella; Lamantia, Elvira; Castaldo, Luigi; Ametrano, Gianluca; Cappuccio, Francesca; Malzone, Gabriella; Montanari, Micaela; Vanacore, Daniela; Romano, Francesco Jacopo; Piscitelli, Raffaele; Pepe, Maria Filomena; D'Aniello, Carmine; Facchini, Gaetano] Progetto ONCONET2 0 Linea Progettuale Implementaz, Regione Campania, Italy.
   [Quagliariello, Vincenzo; Rossetti, Sabrina; Iovane, Gelsomina; Facchini, Gaetano] Ist Nazl Tumori Fdn G Pascale IRCCS, Dept Urogynaecol Oncol, Div Med Oncol, Naples, Italy.
   [Quagliariello, Vincenzo; Iaffaioli, Rosario Vincenzo] Natl Canc Inst G Pascale Fdn, Abdominal Dept, Med Oncol, Naples, Italy.
   [Cavaliere, Carla] SG Moscati Hosp Taranto, Dept Oncoematol Med Oncol, Taranto, Italy.
   [Di Palo, Rossella; Ametrano, Gianluca; Muto, Paolo] Ist Nazl Studio & Cura Tumori Fdn Giovanni Pascal, Radiat Oncol, Naples, Italy.
   [Lamantia, Elvira; Malzone, Gabriella; Pepe, Maria Filomena; Botti, Gerardo] Ist Nazl Tumori Fdn G Pascale IRCCS, Pathol Unit, Naples, Italy.
   [Castaldo, Luigi; Perdona, Sisto] Ist Nazl Tumori Fdn G Pascale IRCCS, Dept Urogynaecol Oncol, Div Urol, Naples, Italy.
   [Nocerino, Flavia; Montella, Maurizio] Ist Nazl Studio & Cura Tumori Fdn Giovanni Pascal, Epidemiol Unit, Naples, Italy.
   [Cappuccio, Francesca; De Falco, Francesco] Ist Nazl Studio & Cura Tumori Fdn Giovanni Pascal, Psicol Unit, Naples, Italy.
   [Montanari, Micaela; Veneziani, Bianca Maria] Univ Naples Federico II, Dept Mol Med & Med Biotechnol, Naples, Italy.
   [Piscitelli, Raffaele; Maiolino, Piera] Ist Nazl Tumori Fdn G Pascale Naples, Ist Nazl Tumori, Pharm Unit, Naples, Italy.
   [Berretta, Massimiliano] Natl Canc Inst, CRO Aviano, Dept Med Oncol, Aviano, Italy.
   [D'Aniello, Carmine] AORN COLLI Osped Monaldi Cotugno CTO, Div Med Oncol, Naples, Italy.
   [Ciliberto, Gennaro] Ist Nazl Studio & Cura Tumori Fdn Giovanni IRCCS, Sci Directorate, Naples, Italy.
   [Caraglia, Michele] Univ Naples 2, Dept Biochem Biophys & Gen Pathol, Naples, Italy.
   [Quagliariello, Vincenzo; Berretta, Massimiliano; Iaffaioli, Rosario Vincenzo; Facchini, Gaetano] Assoc Multidisciplinary Studies Oncol & Mediterra, Piazza Nicola Amore, Naples, Italy.
C3 IRCCS Fondazione Pascale; IRCCS Fondazione Pascale; IRCCS Fondazione
   Pascale; IRCCS Fondazione Pascale; University of Naples Federico II;
   Fondazione IRCCS Istituto Nazionale Tumori Milan; IRCCS Aviano (CRO);
   Universita della Campania Vanvitelli
RP Quagliariello, V (corresponding author), Progetto ONCONET2 0 Linea Progettuale Implementaz, Regione Campania, Italy.; Quagliariello, V (corresponding author), Ist Nazl Tumori Fdn G Pascale IRCCS, Dept Urogynaecol Oncol, Div Med Oncol, Naples, Italy.; Quagliariello, V (corresponding author), Natl Canc Inst G Pascale Fdn, Abdominal Dept, Med Oncol, Naples, Italy.; Quagliariello, V (corresponding author), Assoc Multidisciplinary Studies Oncol & Mediterra, Piazza Nicola Amore, Naples, Italy.
EM quagliariello.enzo@gmail.com
RI Muto, Paolo/AAC-3102-2022; Quagliariello, Vincenzo/GLT-0763-2022;
   Caraglia, Michele/AFY-9729-2022; FACCHINI, GAETANO/P-4491-2015;
   Berretta, Massimiliano/S-5853-2019; Caraglia, Michele/N-5670-2015;
   Quagliariello, Vincenzo/A-8537-2019; Rossetti, Sabrina/J-4963-2018;
   Ciliberto, Gennaro/J-4131-2017; VENEZIANI, Bianca Maria/R-4791-2016
OI FACCHINI, GAETANO/0000-0002-7430-001X; Berretta,
   Massimiliano/0000-0002-9837-9148; Caraglia, Michele/0000-0003-2408-6091;
   Romano, Francesco Jacopo/0000-0002-2361-2486; Botti,
   Gerardo/0000-0002-6287-733X; IOVANE, GELSOMINA/0000-0003-3078-6692;
   Quagliariello, Vincenzo/0000-0002-4557-5401; Rossetti,
   Sabrina/0000-0002-9337-5885; Ciliberto, Gennaro/0000-0003-2851-8605;
   VENEZIANI, Bianca Maria/0000-0002-1678-4183
FU Progetto ONCONET2.0 - Linea progettuale 14 per l'implementazione della
   prevenzione e diagnosi precoce del tumore alla prostata e testicolo -
   Regione Campania, Italy
FX The authors thank Progetto ONCONET2.0 - Linea progettuale 14 per
   l'implementazione della prevenzione e diagnosi precoce del tumore alla
   prostata e testicolo - Regione Campania, Italy for financial support.
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NR 89
TC 37
Z9 41
U1 2
U2 26
PU IMPACT JOURNALS LLC
PI ORCHARD PARK
PA 6666 E QUAKER ST, STE 1, ORCHARD PARK, NY 14127 USA
EI 1949-2553
J9 ONCOTARGET
JI Oncotarget
PD MAY 2
PY 2017
VL 8
IS 18
BP 30606
EP 30616
DI 10.18632/oncotarget.16725
PG 11
WC Oncology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Cell Biology
GA ET7EG
UT WOS:000400456200086
PM 28389628
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Piña, IL
AF Pina, Ileana L.
TI Cardiovascular Disease in Women Challenge of the Middle Years
SO CARDIOLOGY IN REVIEW
LA English
DT Article
DE complications of pregnancy; metabolic syndrome; middle years; risk for
   heart disease
ID GESTATIONAL DIABETES-MELLITUS; METABOLIC SYNDROME; YOUNG-WOMEN;
   RISK-FACTOR; PREGNANCY; PREECLAMPSIA; AWARENESS; MOTHERS; HEALTH
AB Although heart disease remains the primary cause of death among women of all races and ethnic groups in the United States, many women are still unaware of these facts. Health care providers may also not be aware. Lack of awareness among providers may limit or delay the education and intervention to prevent future cardiovascular disease for women in their middle years. In addition, the metabolic syndrome may develop in these years of a woman's life because of today's lifestyle issues and the reported increases in obesity. The appearance of the metabolic syndrome already places a woman in a precarious position for the development of risk factors such as frank hypertension and diabetes. The metabolic syndrome presents an opportunity for providers to enhance surveillance and to educate their patients in the prevention of future events. Complications of pregnancy may also foreshadow the development of hypertension as well as type 2 diabetes mellitus later in life. Some investigators consider pregnancy as an excursion into the metabolic syndrome and as a failed "stress test," if complications such as gestational diabetes or preeclampsia develop. The emergence of those complications may give a more recognized prediction of future cardiovascular events. All primary care providers, including obstetricians and gynecologists, need to be alert as to the follow-up of these women, and incorporate continued vigilance within the standard office visit including waist measurement, annual lipid measurement, glucose monitoring, blood pressure assessment, and intense education and referrals when needed.
C1 [Pina, Ileana L.] Case Western Reserve Univ, Cleveland, OH 44106 USA.
C3 University System of Ohio; Case Western Reserve University
RP Piña, IL (corresponding author), Case Western Reserve Univ, 2627 Fairmount Blvd, Cleveland Hts, OH 44106 USA.
EM ilppina@aol.com
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NR 23
TC 10
Z9 14
U1 0
U2 2
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1061-5377
J9 CARDIOL REV
JI Cardiol. Rev.
PD MAR-APR
PY 2011
VL 19
IS 2
BP 71
EP 75
DI 10.1097/CRD.0b013e318209c233
PG 5
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 715HW
UT WOS:000286875000007
PM 21285666
DA 2025-06-11
ER

PT J
AU Huang, X
   Sun, Y
   Wu, AS
   Zhang, XY
AF Huang, Xiao
   Sun, Yuan
   Wu, Anshi
   Zhang, Xiang-Yang
TI Prevalence and clinical profile of abnormal glucose in first-episode and
   drug-naive patients with major depressive disorder with comorbid
   abnormal thyroid function: a large-scale cross-sectional study
SO BMC PSYCHIATRY
LA English
DT Article
DE Depression; Glucose metabolism; Thyroid function; Prevalence
ID TYPE-2 DIABETES-MELLITUS; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   SYMPTOMS; ANXIETY; METAANALYSIS; ASSOCIATION; TOLERANCE; PREGNANCY;
   CHILDREN
AB BackgroundThe associated factors of abnormal glucose in patients with major depressive disorder (MDD) with comorbid abnormal thyroid function (ATF) remain unclear. To the best of our knowledge, this is the first study with a large sample size that examines the risk factors of abnormal glucose in first-episode drug-naive (FEDN) MDD patients comorbid with ATF and includes clinical correlates and thyroid hormone levels.MethodsA total of 1718 FEDN MDD patients were recruited. The Hamilton Depression Scale (HAMD), Hamilton Anxiety Scale (HAMA), and Positive and Negative Syndrome Scale (PANSS) positive subscale were used to evaluate the symptoms of patients. Fasting blood glucose concentration and thyroid hormone levels were measured.ResultsThe prevalence of abnormal glucose in MDD patients with comorbid ATF was 47.3%, which was 4.25 times higher than that in MDD patients without ATF (17.4%). Compared to those ATF patients without abnormal glucose, ATF patients with abnormal glucose scored higher on HAMD, HAMA and PANSS positive subscale, had a higher rate of suicide attempts, severe anxiety and psychotic symptoms, and had higher levels of thyroid-stimulating hormone (TSH), and thyroid peroxidases antibody (TPOAb) which were also correlated with abnormal glucose in MDD patients comorbid ATF (all P < 0.05). The combination of HAMD score and TSH could differentiate abnormal glucose from ATF. Further, TSH was independence-related with the concentration of fasting blood glucose in MDD patients with comorbid ATF.ConclusionOur results demonstrate a high prevalence of abnormal glucose in MDD patients with comorbid ATF. Some clinical and thyroid function-related variables may be associated with abnormal glucose in MDD patients with comorbid ATF.
C1 [Huang, Xiao; Wu, Anshi] Capital Med Univ, Beijing Chao Yang Hosp, Dept Anesthesiol, 8 Workers Stadium South Rd, Beijing 100020, Peoples R China.
   [Sun, Yuan] Capital Med Univ, Beijing Chao Yang Hosp, Dept Pharm, 8 Workers Stadium South Rd, Beijing 100020, Peoples R China.
   [Zhang, Xiang-Yang] Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China.
   [Zhang, Xiang-Yang] Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China.
   [Zhang, Xiang-Yang] Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, 16 Lincui Rd, Beijing 100101, Peoples R China.
C3 Capital Medical University; Capital Medical University; Chinese Academy
   of Sciences; University of Chinese Academy of Sciences, CAS; Chinese
   Academy of Sciences; Institute of Psychology, CAS
RP Zhang, XY (corresponding author), Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China.; Zhang, XY (corresponding author), Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China.; Zhang, XY (corresponding author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, 16 Lincui Rd, Beijing 100101, Peoples R China.
EM zhangxy@psych.ac.cn
RI Zhang, Xiangyang/ABC-7380-2022
OI Zhang, Xiangyang/0000-0003-3326-382X
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NR 46
TC 1
Z9 1
U1 1
U2 4
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-244X
J9 BMC PSYCHIATRY
JI BMC Psychiatry
PD MAY 24
PY 2023
VL 23
IS 1
AR 362
DI 10.1186/s12888-023-04842-5
PG 9
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychiatry
GA H2XK2
UT WOS:000994645700004
PM 37226146
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Leiva, E
   Mujica, V
   Sepúlveda, P
   Guzmán, L
   Núñez, S
   Orrego, R
   Palomo, I
   Andrews, M
   Arredondo, MA
AF Leiva, Elba
   Mujica, Veronica
   Sepulveda, Pablo
   Guzman, Luis
   Nunez, Sergio
   Orrego, Roxana
   Palomo, Ivan
   Andrews, Monica
   Arredondo, Miguel A.
TI High Levels of Iron Status and Oxidative Stress in Patients with
   Metabolic Syndrome
SO BIOLOGICAL TRACE ELEMENT RESEARCH
LA English
DT Article
DE Iron; Oxidative stress; oxLDL; TBARS; Insulin; Metabolic syndrome
ID LOW-DENSITY-LIPOPROTEIN; INSULIN-RESISTANCE; ATHEROSCLEROSIS;
   TRANSFERRIN; FERRITIN; RECEPTOR; OBESITY; HYPERGLYCEMIA; DEGRADATION;
   CHOLESTEROL
AB Studies concerning oxidative stress (OxE) parameters have increased, mainly because of its important role in cardiovascular diseases and diabetes complications. The main objective of this study was to evaluate iron nutrition status and oxidative stress parameters in subjects that had developed metabolic syndrome (MetS). Subjects from the Research Program of Risk Factors for Cardiovascular Disease (n = 155) were studied (ages ranging from 45 to 65 years old) and classified according to the Adult Treatment Panel III criterion. A blood sample was taken after a 12-h fasting period, and basal glucose, insulin, thiobarbituric acid reactive substances (TBARS), oxidized LDL (oxLDL), heme oxygenase (HO) activity, lipid profile, and iron nutrition status were determined. Eighty-five subjects were classified as MetS, and 70 non-MetS. Individuals with MetS showed higher Fe storage (high levels of ferritin, total body iron and low transferrin receptor), oxLDL, TBARS, and homeostatic model assessment for insulin resistance levels. The MetS group showed high levels of oxidative stress parameters (HO activity, oxLDL, and TBARS). The presence of MetS showed an association with LDL oxidation risk (multiple lineal regression according to sex and age, p < 0.001). High levels of triglycerides (p < 0.001) and waist circumference (p < 0.012) were associated with oxLDL levels, as well as an association between TBARS and oxLDL with ferritin levels. Through logistic regression analyses, the highest quartile of ferritin was associated with a threefold risk of developing MetS compared to the lowest quartile; also, TBARS showed a 21-fold risk for the development of MetS. Finally, elevated levels of oxidative stress parameters such us oxLDL, TBARS, HO, and Fe storage were associated to MetS.
C1 [Leiva, Elba; Sepulveda, Pablo; Guzman, Luis; Nunez, Sergio; Orrego, Roxana; Palomo, Ivan] Univ Talca, Res Program Risk Factors Cardiovasc Dis, Dept Clin Biochem & Immunohematol, Fac Hlth Sci, Talca, Chile.
   [Mujica, Veronica] Maule Hlth Serv, Cardiovasc Program, Talca, France.
   [Andrews, Monica; Arredondo, Miguel A.] Univ Chile, Micronutrient Lab, Nutr Inst & Food Technol INTA, Santiago, Chile.
C3 Universidad de Talca; Universidad de Chile
RP Arredondo, MA (corresponding author), Univ Chile, Micronutrient Lab, Nutr Inst & Food Technol INTA, Santiago, Chile.
EM marredon@inta.cl
RI wehinger, sergio/L-3610-2017; Palomo, Iván/I-4321-2018; Guzmán,
   Luis/HLH-3515-2023; Sepúlveda, Pablo/HCI-5123-2022; Andrews,
   Monica/I-2301-2013
OI Palomo, Ivan/0000-0002-9618-8778; wehinger, sergio/0000-0001-7021-3544;
   Guzman, Luis/0000-0003-1552-7430; Mujica, Veronica/0000-0001-6290-410X
FU Research Program of Risk Factors for Cardiovascular Disease at the
   School of Health Science, University of Talca, Chile; Fondecyt [1085173]
FX This research was supported by Research Program of Risk Factors for
   Cardiovascular Disease at the School of Health Science, University of
   Talca, Chile and Fondecyt Grant (#1085173) to MAO.
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NR 44
TC 27
Z9 31
U1 0
U2 29
PU HUMANA PRESS INC
PI TOTOWA
PA 999 RIVERVIEW DRIVE SUITE 208, TOTOWA, NJ 07512 USA
SN 0163-4984
EI 1559-0720
J9 BIOL TRACE ELEM RES
JI Biol. Trace Elem. Res.
PD JAN
PY 2013
VL 151
IS 1
BP 1
EP 8
DI 10.1007/s12011-012-9525-3
PG 8
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 061WK
UT WOS:000312880700001
PM 23079936
DA 2025-06-11
ER

PT J
AU Hung, CH
   Yu, CY
   Huang, MC
AF Hung, Chich-Hsiu
   Yu, Ching-Yun
   Huang, Mei-Chuan
TI The Perinatal Biopsychosocial Consequences of Various Levels of
   Gestational Hyperglycemia
SO CLINICAL NURSING RESEARCH
LA English
DT Article
DE blood pressure; depression; fasting blood sugar; gestational
   hyperglycemia; health status
ID BODY-MASS INDEX; METABOLIC-SYNDROME; DIABETES-MELLITUS; MATERNAL
   HYPERGLYCEMIA; WOMEN; COMPLICATIONS; GLUCOSE; PREDICTORS; PREGNANCY;
   OBESITY
AB This study was to compare biopsychosocial consequences among three groups of women with gestational hyperglycemia. We conducted a repeated-measures study at five time points among 132 women with gestational hyperglycemia. Women's physiological indicators and their psychosocial indicators were measured. There were 22.7% of participants had gestational diabetes mellitus (GDM), 11.4% had gestational impaired glucose tolerance (G-IGT), and 65.9% had mild gestational hyperglycemia (MGH). Women with GDM had higher fasting blood glucose and systolic/diastolic blood pressure than women with MGH. Women with GDM had higher diastolic blood pressure compared to women with G-IGT. Significant differences were found between the five time points regarding women's fasting blood glucose, diastolic blood pressure, depression, and health status. Health care providers should conduct early screening for predictors of metabolic syndrome in women with any degree of gestational hyperglycemia. Nursing interventions could be offered as early as the perinatal period to promote women's health.
C1 [Hung, Chich-Hsiu; Yu, Ching-Yun] Kaohsiung Med Univ, Sch Nursing, 100 Shih Chuan 1st Rd, Kaohsiung 80708, Taiwan.
   [Hung, Chich-Hsiu] Kaohsiung Med Univ Hosp, Dept Med Res, Kaohsiung, Taiwan.
   [Huang, Mei-Chuan] Natl Tainan Jr Coll Nursing, Sch Nursing, Tainan, Taiwan.
C3 Kaohsiung Medical University; Kaohsiung Medical University; Kaohsiung
   Medical University Hospital
RP Hung, CH (corresponding author), Kaohsiung Med Univ, Sch Nursing, 100 Shih Chuan 1st Rd, Kaohsiung 80708, Taiwan.
EM chhung@kmu.edu.tw
RI Hung, Chich-Hsiu/C-7589-2009
FU National Science Council, Taiwan [NSC 96-2314-B-037-078-MY3]
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: This study
   was funded in part by the National Science Council, Taiwan (NSC
   96-2314-B-037-078-MY3).
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NR 30
TC 2
Z9 2
U1 1
U2 11
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1054-7738
EI 1552-3799
J9 CLIN NURS RES
JI Clin. Nurs. Res.
PD MAY
PY 2020
VL 29
IS 4
BP 268
EP 275
DI 10.1177/1054773818769210
PG 8
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA LM6HY
UT WOS:000532351400009
PM 29631415
DA 2025-06-11
ER

PT J
AU Susin, N
   Boff, RD
   Ludwig, MWB
   Feoli, AMP
   da Silva, AG
   Macagnan, FE
   Oliveira, MD
AF Susin, Nathalia
   Boff, Raquel de Melo
   Brusius Ludwig, Martha Walig
   Pandolfo Feoli, Ana Maria
   da Silva, Andreia Gustavo
   Macagnan, Fabricio Elder
   Oliveira, Margareth da Silva
TI Predictors of adherence in a prevention program for patients with
   metabolic syndrome
SO JOURNAL OF HEALTH PSYCHOLOGY
LA English
DT Article
DE chronic disease; intervention treatment adherence; lifestyle; metabolic
   syndrome
ID LIFE-STYLE INTERVENTION; PHYSICAL-ACTIVITY; CARDIOVASCULAR-DISEASE;
   DEPRESSIVE SYMPTOMS; SELF-EFFICACY; OLDER-ADULTS; DROP-OUT; RISK;
   THERAPY; OBESITY
AB The study objectives were (1) comparison of baseline characteristics between individuals with metabolic syndrome, adhering/not adhering to a primary prevention program modificacAo do estilo de vida e risco cardiovascular; and (2) determination of risk factors for program adherence. The sample included 127 participants with mean age (+/- standard deviation) of 49.58 (+/- 7.77)years, participating in the modificacAo do estilo de vida e risco cardiovascular between 2010 and 2012. Results show that program adherence predictors were age (odds ratio: 1.134, 95% confidence interval: 1.106-1.833); practicing physical exercise (odds ratio: 1.322, 95% confidence interval: 1.115-7.589); self-efficacy for regular eating habits (odds ratio: 2.044, 95% confidence interval: 1.184-3.377); low binge eating scores (odds ratio: 1.922, 95% confidence interval: 1.118-3.974); and low isolation and depression scores (odds ratio: 0.721, 95% confidence interval: 0.322-0.917).
C1 [Susin, Nathalia; Boff, Raquel de Melo; Brusius Ludwig, Martha Walig; Pandolfo Feoli, Ana Maria; da Silva, Andreia Gustavo; Oliveira, Margareth da Silva] Pontificia Univ Catolica Rio Grande Sul PUCRS, Ave Ipiranga 6681, BR-90619900 Porto Alegre, RS, Brazil.
   [Macagnan, Fabricio Elder] Univ Fed Ciencias Saude Porto Alegre, Porto Alegre, RS, Brazil.
C3 Pontificia Universidade Catolica Do Rio Grande Do Sul; Universidade
   Federal de Ciencias da Saude de Porto Alegre
RP Boff, RD (corresponding author), Pontificia Univ Catolica Rio Grande Sul PUCRS, Ave Ipiranga 6681, BR-90619900 Porto Alegre, RS, Brazil.
EM rmboff@hotmail.com
RI Macagnan, Fabrício/AAP-5564-2021; Feoli, Ana/A-1748-2015; de Melo Boff,
   Raquel/AAX-2376-2020; da Silva Oliveira, Margareth/K-9670-2015
OI da Silva Oliveira, Margareth/0000-0002-6490-5170
FU Brazilian government through the Conselho Nacional de Desenvolvimento
   Cientifico e Tecnologico - CNPq; Coordenacao de Aperfeicoamento de
   Pessoal de Nivel Superior - CAPES
FX This research has received funds from the Brazilian government through
   the Conselho Nacional de Desenvolvimento Cientifico e Tecnologico - CNPq
   and Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior - CAPES.
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NR 49
TC 17
Z9 22
U1 1
U2 13
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1359-1053
EI 1461-7277
J9 J HEALTH PSYCHOL
JI J. Health Psychol.
PD OCT
PY 2016
VL 21
IS 10
BP 2156
EP 2167
DI 10.1177/1359105315572451
PG 12
WC Psychology, Clinical
WE Social Science Citation Index (SSCI)
SC Psychology
GA DX9AD
UT WOS:000384683800004
PM 25805660
OA Green Published
DA 2025-06-11
ER

PT J
AU Algandaby, MM
AF Algandaby, Mardi M.
TI Crocin attenuates metabolic syndrome-induced osteoporosis in rats
SO JOURNAL OF FOOD BIOCHEMISTRY
LA English
DT Article
DE carotenoids; crocin; metabolic syndrome; osteoporosis; saffron; spices
ID LIPID PROFILE; BONE; ASSOCIATION; SATIVUS; SAFFRON; INFLAMMATION;
   COMPONENTS; MORTALITY; FRACTURE; MEN
AB In the current study, anti-osteoporotic activities of crocin were evaluated in a rat model of metabolic syndrome-induced osteoporosis. Metabolic syndrome was confirmed by increased body weight gain, increased fasting blood glucose, hyperinsulinemia, elevated mean arterial blood pressure, and increased serum triglycerides level. Crocin (5 or 10 mg/kg) protected against histological and architectural alteration in bone tissues. Further, it ameliorated the decline in the bone formation markers serum alkaline phosphatase activity and osteocalcin level and inhibited the rise in the bone resorption markers serum tartrate-resistant acid phosphatase and collagen cross-linking carboxyterminal telopeptide, type I. Crocin anti-inflammatory properties were confirmed by a significant decline in serum interleukin-6 and tumor necrosis factor-alpha. Crocin mitigated oxidative stress in femur distal epiphysis tissues. Mechanically, crocin enhanced both the longitudinal and perpendicular forces of femurs. The current data highlight a protective activity that can be attributed, at least partly, to its anti-inflammatory and antioxidant activities. Practical applications Metabolic syndrome is a serious health problem. Its prevalence is present in approximately 25% of all adults. Complications of metabolic syndrome include osteoporosis. This poses high risk of fractures and represents a heavy health, social, and economic burden. The current study highlights the antiosteoporotic activities of crocin in an experimental model of osteoporosis. Thus, crocin and/or other structurally related carotenoids can be lead compounds for synthesizing more potent and bioavailable molecules. These are expected to be devoid of the hazardous adverse effects of the currently available medicaments.
C1 [Algandaby, Mardi M.] King Abdulaziz Univ, Med Plants Res Grp, Sci Res, Jeddah, Saudi Arabia.
   [Algandaby, Mardi M.] King Abdulaziz Univ, Dept Biol Sci, Fac Sci, Jeddah 21589, Saudi Arabia.
C3 King Abdulaziz University; King Abdulaziz University
RP Algandaby, MM (corresponding author), King Abdulaziz Univ, Dept Biol Sci, Fac Sci, Jeddah 21589, Saudi Arabia.
EM malgandaby@kau.edu.sa
RI Algandaby, Mardi/M-9861-2015
FU Deanship of Scientific Research, King Abdulaziz University [1-166-35 RG]
FX Deanship of Scientific Research, King Abdulaziz University, Grant/Award
   Number: 1-166-35 RG
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NR 36
TC 15
Z9 15
U1 1
U2 12
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0145-8884
EI 1745-4514
J9 J FOOD BIOCHEM
JI J. Food Biochem.
PD JUL
PY 2019
VL 43
IS 7
AR e12895
DI 10.1111/jfbc.12895
PG 8
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA IH2CS
UT WOS:000474303400054
PM 31353703
OA gold
DA 2025-06-11
ER

PT J
AU Maes, M
   Vasupanrajit, A
   Jirakran, K
   Zhou, B
   Tunvirachaisakul, C
   Almulla, AF
AF Maes, Michael
   Vasupanrajit, Asara
   Jirakran, Ketsupar
   Zhou, Bo
   Tunvirachaisakul, Chavit
   Almulla, Abbas F.
TI First-episode mild depression in young adults is a pre-proatherogenic
   condition even in the absence of subclinical metabolic syndrome: lowered
   lecithin-cholesterol acyltransferase as a key factor
SO NEUROENDOCRINOLOGY LETTERS
LA English
DT Article
DE oxidative stress; suicidal ideation; mood disorders; affective spectrum;
   neuro-immune; antioxidants
ID BLOOD-BRAIN-BARRIER; BIPOLAR DISORDER; MAJOR DEPRESSION; RATING-SCALE;
   HDL; LCAT; PLASMA; TOXICITY; INSIGHTS; LIPIDS
AB BACKGROUND: Major depression is classified into distinct subtypes: simple (SDMD) and major dysmood disorder (MDMD). MDMD patients exhibit elevated atherogenicity and decreased reverse cholesterol transport (RCT). However, comprehensive data regarding lipid metabolism is absent in first episode (FE)-SDMD. AIMS: In this case-control study, plasma lipid levels, lecithin-cholesterol acyltransferase (LCAT), free cholesterol, apolipoprotein (Apo)A1, ApoB, and ApoE are compared between academic students with first episode SDMD (FE-SDMD) (n = 44) or SDMD (n = 64) and control students (n = 44), after excluding those with metabolic syndrome (MetS). RESULTS: LCAT is decreased, and free cholesterol and ApoE increased in subjects with SDMD and FE-SDMD as compared with controls. There were no significant alterations in high-density lipoprotein cholesterol (HDLc), ApoA1, RCT, ApoB and triglycerides in SDMD. LCAT, free cholesterol and atherogenicity indices are significantly associated with suicidal behaviors and the SDMD phenome. The effects of LCAT on those phenome features is completely mediated by free cholesterol and brooding. SDMD and FE-SDMD patients without signs of subclinical MetS show lowered LCAT and increased free cholesterol as compared with normal controls. There are significant interactions between the SDMD and FE-SDMD diagnosis and subclinical MetS, which result in decreased HDLc and RCT, and an increased ApoB/ApoA ratio. DISCUSSION: FE-SDMD and SDMD are pre-proatherogenic states, because of decreased LCAT, and increased free cholesterol and ApoE, and their intersections with subclinical MetS. These aberrations may drive atherogenicity, and activation of peripheral and central oxidative, neuro-immune, and degenerative pathways. Individuals with FE-SDMD should be screened and treated for increased atherogenicity risk by measuring free cholesterol and ApoE.
C1 [Maes, Michael; Zhou, Bo; Almulla, Abbas F.] Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Sichuan Prov Ctr Mental Hlth, Sch Med, Chengdu 610072, Peoples R China.
   [Maes, Michael; Zhou, Bo; Almulla, Abbas F.] Chinese Acad Med Sci, Key Lab Psychosomat Med, Chengdu 610072, Peoples R China.
   [Maes, Michael; Vasupanrajit, Asara; Jirakran, Ketsupar; Zhou, Bo; Tunvirachaisakul, Chavit; Almulla, Abbas F.] Chulalongkorn Univ, Fac Med, Dept Psychiat, Bangkok, Thailand.
   [Maes, Michael; Vasupanrajit, Asara; Jirakran, Ketsupar; Tunvirachaisakul, Chavit] Chulalongkorn Univ, Fac Med, Dept Psychiat, PhD Program Mental Hlth, Bangkok, Thailand.
   [Maes, Michael; Tunvirachaisakul, Chavit] Chulalongkorn Univ, Fac Med, Cognit Impairment & Dementia Res Unit, Bangkok, Thailand.
   [Maes, Michael] Chulalongkorn Univ, Cognit Fitness & Biopsychol Technol Res Unit, Fac Med, Bangkok 10330, Thailand.
   [Maes, Michael] Med Univ Plovdiv, Dept Psychiat, Plovdiv, Bulgaria.
   [Maes, Michael] Med Univ Plovdiv, Res Inst, Plovdiv, Bulgaria.
   [Maes, Michael] 26 Kyungheedae Ro, Seoul 02447, South Korea.
   [Almulla, Abbas F.] Islamic Univ, Coll Med Technol, Med Lab Technol Dept, Najaf, Iraq.
C3 Sichuan Provincial People's Hospital; University of Electronic Science &
   Technology of China; Chinese Academy of Medical Sciences - Peking Union
   Medical College; Chulalongkorn University; Chulalongkorn University;
   Chulalongkorn University; Chulalongkorn University; Medical University
   Plovdiv; Medical University Plovdiv; Islamic University College
RP Maes, M; Zhou, B (corresponding author), Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Sichuan Prov Ctr Mental Hlth, Sch Med, Chengdu 610072, Peoples R China.; Maes, M; Zhou, B (corresponding author), Chulalongkorn Univ, Fac Med, Dept Psychiat, Bangkok, Thailand.
RI Maes, Michael/B-8546-2011; Vasupanrajit, Asara/ABG-5437-2021; Almulla,
   Abbas F./ABG-7926-2020
FU Sompoch Endowment Fund (Faculty of Medicine) [HEA663000016];  [MDCU
   (RA66/016)]
FX The study was supported by the 90th Anniversary of Chulalongkorn
   University Scholarship under the Ratchadaphisek Somphot Fund (Batch#47),
   and the Ratchadaphisek Somphot Fund (Faculty of Medicine), MDCU
   (GA65/17), Chulalongkorn University, Thailand, to AV; and the Thailand
   Science Research, and Innovation Fund at Chulalongkorn University
   (HEA663000016), and a Sompoch Endowment Fund (Faculty of Medicine) MDCU
   (RA66/016) to MM.
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NR 68
TC 0
Z9 0
U1 2
U2 2
PU MAGHIRA & MAAS PUBLICATIONS
PI MUNSBACH
PA MAGHIRA & MAAS S A R L, 6C, RUE GABRIEL LIPPMANN, L-5365 MUNSBACH,
   LUXEMBOURG
SN 0172-780X
EI 2354-4716
J9 NEUROENDOCRINOL LETT
JI Neuroendocrinol. Lett.
PY 2024
VL 45
IS 7-8
PG 128
WC Endocrinology & Metabolism; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology
GA 1CL0L
UT WOS:001461713200007
DA 2025-06-11
ER

PT J
AU Liang, XP
   Or, B
   Tsoi, MF
   Cheung, CL
   Cheung, BMY
AF Liang, Xiaopeng
   Or, Benjamin
   Tsoi, Man F.
   Cheung, Ching L.
   Cheung, Bernard M. Y.
TI Prevalence of metabolic syndrome in the United States National Health
   and Nutrition Examination Survey 2011-18
SO POSTGRADUATE MEDICAL JOURNAL
LA English
DT Article
DE metabolic syndrome; prevalence; NHANES
ID US ADULTS; SOCIOECONOMIC-STATUS; TRENDS; DEPRESSION
AB Purpose To estimate the prevalence of metabolic syndrome (MetS) in the US National Health and Nutrition Examination Survey (NHANES) 2011-18. Methods This study included 8183 eligible nonpregnant participants aged & GE;20 years from the NHANES 2011-18. MetS was defined as the presence of at least three of the following components: central obesity, reduced high-density lipoprotein cholesterol, elevated triglycerides, elevated blood pressure, and elevated fasting blood glucose. The prevalence of MetS was estimated taking into account the complex sampling. The time trend was evaluated using logistic regression. Results The total prevalence of MetS increased from 37.6% [95% confidence interval (CI): 34.0%-41.4%] in 2011-12 to 41.8% (95% CI: 38.1%-45.7%) in 2017-18 (P for trend = .028). Among the MetS components, the prevalence of elevated glucose increased from 48.9% (95% CI: 45.7%-52.5%) in 2011-12 to 64.7% (95% CI: 61.4%-67.9%) in 2017-18 (P for trend <.001). The prevalence of MetS in participants with low educational attainment increased from 44.4% (95% CI: 38.8%-50.1%) in 2011-12 to 55.0% (95% CI: 50.8%-59.1%) in 2017-18 (P for trend = .01). Conclusion The prevalence of MetS increased during 2011-18, notably in participants with low educational attainment. Lifestyle modification is needed to prevent MetS and the associated risks of diabetes and cardiovascular disease. Key messages What is already known on this topic: Prevalence of metabolic syndrome is an index of the cardiometabolic health of a population. What this study adds: The prevalence of metabolic syndrome in US adults increased during 2011-18, notably in participants with low educational attainment. How this study might affect research, practice, or policy: Lifestyle modification is needed to prevent metabolic syndrome and the associated risks of diabetes and cardiovascular disease.
C1 [Liang, Xiaopeng; Or, Benjamin; Tsoi, Man F.; Cheung, Bernard M. Y.] Univ Hong Kong, Sch Clin Med, Dept Med, Div Clin Pharmacol & Therapeut, Hong Kong, Peoples R China.
   [Tsoi, Man F.] Univ Manchester, Ctr Epidemiol Versus Arthrit, Manchester M13 9PT, England.
   [Cheung, Ching L.; Cheung, Bernard M. Y.] Univ Hong Kong, State Key Lab Pharmaceut Biotechnol, Hong Kong, Peoples R China.
   [Cheung, Ching L.] Univ Hong Kong, Dept Pharmacol & Pharm, Hong Kong, Peoples R China.
   [Cheung, Ching L.; Cheung, Bernard M. Y.] Univ Hong Kong, Inst Cardiovasc Sci & Med, Hong Kong, Peoples R China.
   [Cheung, Bernard M. Y.] Univ Hong Kong, Queen Mary Hosp, Sch Clin Med, Dept Med, 102 Pokfulam Rd, Hong Kong, Peoples R China.
C3 University of Hong Kong; University of Manchester; University of Hong
   Kong; University of Hong Kong; University of Hong Kong; University of
   Hong Kong
RP Cheung, BMY (corresponding author), Univ Hong Kong, Queen Mary Hosp, Sch Clin Med, Dept Med, 102 Pokfulam Rd, Hong Kong, Peoples R China.
EM xpliang@connect.hku.hk; ocybenm@connect.hku.hk;
   simon.tsoi@manchester.ac.uk; lung1212@hku.hk; mycheung@hku.hk
RI Cheung, Ching-Lung/C-2529-2012; Tsoi, Man Fung/J-6964-2016
OI Tsoi, Man Fung/0000-0002-9892-0125
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NR 30
TC 86
Z9 90
U1 10
U2 26
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0032-5473
EI 1469-0756
J9 POSTGRAD MED J
JI Postgrad. Med. J.
PD AUG 22
PY 2023
VL 99
IS 1175
BP 985
EP 992
DI 10.1093/postmj/qgad008
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA P7ST7
UT WOS:001052641900006
PM 36906842
OA hybrid
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Camargo, A
   Peña-Orihuela, P
   Rangel-Zúñiga, OA
   Pérez-Martínez, P
   Delgado-Lista, J
   Cruz-Teno, C
   Marín, C
   Tinahones, F
   Malagón, MM
   Roche, HM
   Pérez-Jiménez, F
   López-Miranda, J
AF Camargo, Antonio
   Pena-Orihuela, Patricia
   Alberto Rangel-Zuniga, Oriol
   Perez-Martinez, Pablo
   Delgado-Lista, Javier
   Cruz-Teno, Cristina
   Marin, Carmen
   Tinahones, Francisco
   Malagon, Maria M.
   Roche, Helen M.
   Perez-Jimenez, Francisco
   Lopez-Miranda, Jose
TI Peripheral blood mononuclear cells as in vivo model for dietary
   intervention induced systemic oxidative stress
SO FOOD AND CHEMICAL TOXICOLOGY
LA English
DT Article
DE Mononuclear cells; Oxidative stress; Diet; Metabolic syndrome;
   Postprandial state; LIPGENE study
ID ANTIOXIDANT GENE-EXPRESSION; METABOLIC SYNDROME; ADIPOSE-TISSUE;
   EXERCISE INTERVENTION; MEDITERRANEAN DIET; ELDERLY-MEN; HIGH-FAT; OBESE;
   ACTIVATION; INFILTRATION
AB Our aim was to assess the use of peripheral blood mononuclear cells (PBMC) as an in vivo cellular model to evaluate diet-induced changes in the oxidative stress status by analyzing the gene expression pattern of NADPH-oxidase subunits and antioxidant genes. A randomized, controlled trial assigned metabolic syndrome patients to 4 diets for 12 weeks each: (i) high-saturated fatty acid (HSFA), (ii) high-monounsaturated fatty acid, and (iii), (iv) two low-fat, high-complex carbohydrate diets supplemented with n-3 polyunsaturated fatty acids or placebo. A fat challenge reflecting the fatty acid composition as the original diets was conducted post-intervention. The mRNA levels of gp91(phox) (P < 0.001), p22(Phox) (P = 0.005), p47(Phox) (P = 0.001) and p40(Phox) (P < 0.001) increased at 2 h after the intake of the HSFA meal. The expression of SOD1, SOD2, GSR, GPx1, GPX4, TXN, TXNRD1 and Nrf2 increased after the HSFA meal (p < 0.05). In contrast, the expression of these genes remained unaltered in response to the other dietary interventions. Our results suggest that the increased expression of antioxidant genes in PBMC seems to be due to the response to the postprandial oxidative stress generated mainly in adipose tissue after the consumption of an HSFA diet. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Camargo, Antonio; Pena-Orihuela, Patricia; Alberto Rangel-Zuniga, Oriol; Perez-Martinez, Pablo; Delgado-Lista, Javier; Cruz-Teno, Cristina; Marin, Carmen; Perez-Jimenez, Francisco; Lopez-Miranda, Jose] Univ Cordoba, IMIBIC Reina Sofia Univ Hosp, Lipids & Atherosclerosis Unit, Cordoba, Spain.
   [Camargo, Antonio; Pena-Orihuela, Patricia; Alberto Rangel-Zuniga, Oriol; Perez-Martinez, Pablo; Delgado-Lista, Javier; Cruz-Teno, Cristina; Marin, Carmen; Tinahones, Francisco; Malagon, Maria M.; Perez-Jimenez, Francisco; Lopez-Miranda, Jose] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr CIBEROBN, Madrid, Spain.
   [Tinahones, Francisco] Hosp Virgen Victoria, Endocrinol & Nutr Serv, Malaga, Spain.
   [Malagon, Maria M.] Univ Cordoba, IMIBIC Reina Sofia Univ Hosp, Dept Cell Biol Physiol & Immunol, Cordoba, Spain.
   [Roche, Helen M.] Univ Coll Dublin, Sch Publ Hlth & Populat Sci, UCD Inst Food & Hlth, UCD Conway Inst, Dublin, Ireland.
C3 Universidad de Cordoba; CIBER - Centro de Investigacion Biomedica en
   Red; CIBEROBN; Instituto de Salud Carlos III; Universidad de Cordoba;
   University College Dublin
RP López-Miranda, J (corresponding author), Hosp Univ Reina Sofia, Med Interna Serv, Unidad Lipidos & Arteriosclerosis, Avda Menendez Pidal S-N, Cordoba 14004, Spain.
EM jlopezmir@uco.es
RI Marin Hinojosa, Carmen/AFO-1294-2022; Delgado-Lista,
   Javier/KAM-7412-2024; Lopez-Miranda, Jose/Y-8306-2019; Roche,
   Helen/AAF-4164-2019; Jimenez, Francisco/AAJ-9559-2021; Tinahones,
   Francisco/AAB-2882-2020; MALAGON, MARIA M/L-5386-2014; Perez Martinez,
   Pablo/AEL-6176-2022; Camargo Garcia, Antonio/G-9720-2015
OI MALAGON, MARIA M/0000-0002-2419-2727; Delgado Lista, Francisco
   Javier/0000-0002-2982-2716; Tinahones, Francisco J/0000-0001-6871-4403;
   Roche, Helen/0000-0002-0628-3318; Perez Jimenez,
   Francisco/0000-0001-9808-1280; Lopez-Miranda, Jose/0000-0002-8844-0718;
   Perez Martinez, Pablo/0000-0001-7716-8117; Rangel-Zuniga, Oriol
   Alberto/0000-0003-3495-5705; Perez-Jimenez,
   Francisco/0000-0001-7499-7681; Pena Orihuela, Patricia
   J/0009-0009-9970-043X; Camargo Garcia, Antonio/0000-0002-0415-4184
FU European Union [505944]; Ministerio de Ciencia e Innovacion
   [AGL2004-07907, AGL2006-01979, AGL2009-2270, AGL2012-39615]; CIBER
   Fisiopatologia de la Obesidad y Nutricion [CB06/03/0047]; Consejeria de
   Innovacion, Ciencia y Empresa, Junta de Andalucia [P06-CTS-01425,
   CTS-03039]; Consejeria de Salud, Junta de Andalucia [06/128, 07/43,
   PI-0193]; Fondo Europeo de Desarrollo Regional (FEDER); Programa de
   Formacion de Profesorado Universitario (FPU) del Ministerio de
   Educacion, Gobierno de Espana
FX The CIBEROBN is an initiative of the Instituto de Salud Carlos III,
   Madrid, Spain. This work was supported in part by Research Grants from
   the European Union [LIPGENE European Integrated Project-505944], from
   the Ministerio de Ciencia e Innovacion [Grant Numbers AGL2004-07907,
   AGL2006-01979, AGL2009-2270, AGL2012-39615 (to J.L.-M.)]; CIBER
   Fisiopatologia de la Obesidad y Nutricion [Grant Number CB06/03/0047];
   Consejeria de Innovacion, Ciencia y Empresa, Junta de Andalucia [Grant
   Number P06-CTS-01425 (to J.L.-M.) CTS-03039 (to M.M.M.)]; and Consejeria
   de Salud, Junta de Andalucia [Grant Numbers 06/128, 07/43, PI-0193 (to
   J.L.-M.)].); Fondo Europeo de Desarrollo Regional (FEDER). P.P-O has a
   fellowship from Programa de Formacion de Profesorado Universitario (FPU)
   del Ministerio de Educacion, Gobierno de Espana.
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NR 50
TC 16
Z9 16
U1 0
U2 11
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0278-6915
EI 1873-6351
J9 FOOD CHEM TOXICOL
JI Food Chem. Toxicol.
PD OCT
PY 2014
VL 72
BP 178
EP 186
DI 10.1016/j.fct.2014.07.024
PG 9
WC Food Science & Technology; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Toxicology
GA AR5NI
UT WOS:000343630800022
PM 25057809
DA 2025-06-11
ER

PT J
AU Chang, JS
   Namkung, J
AF Chang, Jae Seung
   Namkung, Jun
TI Effects of Exercise Intervention on Mitochondrial Stress Biomarkers in
   Metabolic Syndrome Patients: A Randomized Controlled Trial
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Article
DE metabolic syndrome; exercise training; randomized controlled trial;
   biomarker; growth differentiation factor 15; fibroblast growth factor
   21; angiopoietin-like 6; leptin
AB Metabolic syndrome (MetS) pathogenesis involves oxidative stress associated with mitochondrial dysfunction, which triggers integrated stress responses via various compensatory metabolic modulators like mitokines and hepatokines. However, the regulatory mechanisms underlying the exercise-derived benefits with respect to mitokines and hepatokines (potential MetS biomarkers) are unknown. Thus, we investigated the effects of exercise training on MetS biomarkers and their associations with clinical parameters. In this single-center trial, 30 women with MetS were randomly assigned to 12-week supervised exercise or control groups (1:1) and compared with 12 age-matched healthy volunteers. All participants completed the study except one subject in the control group. Expectedly, serum levels of the mitokines, fibroblast growth factor-21 (FGF21), growth differentiation factor-15 (GDF15), and the hepatokine, angiopoietin-like 6 (ANGPTL6), were higher in MetS patients than in healthy volunteers. Moreover, their levels were markedly attenuated in the exercise group. Further, exercise-mediated changes in serum FGF21 and GDF15 correlated with changes in the homeostasis model of assessment of insulin resistance (HOMA-IR) and appendicular lean mass (ALM), respectively. Additionally, changes in serum triglycerides and ANGPTL6 were correlated with changes in leptin. Aberrant mitokine and hepatokine levels can be rectified by relieving metabolic stress burden. Therefore, exercise training may reduce the need for the compensatory upregulation of MetS metabolic modulators by improving gluco-lipid metabolism.
C1 [Chang, Jae Seung; Namkung, Jun] Yonsei Univ, Wonju Coll Med, Mitohormesis Res Ctr, 20 Ilsan Ro, Wonju 26426, Gangwon Do, South Korea.
   [Chang, Jae Seung] Yonsei Inst Sports Sci & Exercise Med YISSEM, 20 Ilsan Ro, Wonju 26426, Gangwon Do, South Korea.
   [Namkung, Jun] Yonsei Univ, Wonju Coll Med, Dept Biochem, 20 Ilsan Ro, Wonju 26426, Gangwon Do, South Korea.
C3 Yonsei University; Yonsei University
RP Namkung, J (corresponding author), Yonsei Univ, Wonju Coll Med, Mitohormesis Res Ctr, 20 Ilsan Ro, Wonju 26426, Gangwon Do, South Korea.; Namkung, J (corresponding author), Yonsei Univ, Wonju Coll Med, Dept Biochem, 20 Ilsan Ro, Wonju 26426, Gangwon Do, South Korea.
EM godbless@yonsei.ac.kr; junitive@yonsei.ac.kr
RI NAMKUNG, Jun/AAJ-4549-2020; Chang, Jae Seung/JED-9976-2023
OI Namkung, Jun/0000-0003-0515-0860; Chang, Jae Seung/0000-0002-4047-1128
FU National Research Foundation of Korea - Ministry of Science, ICT &
   Future Planning [NRF-2017R1A5A2015369, NRF-2018R1C1B6005036,
   NRF-2019R1A2C4070048]; Yonsei UniversityWonju Campus Future-Leading
   Research Initiative [2019-52-0052]
FX This studywas supported by grants fromtheNational Research Foundation of
   Korea funded by theMinistry of Science, ICT & Future Planning
   (NRF-2017R1A5A2015369, NRF-2018R1C1B6005036, NRF-2019R1A2C4070048). This
   work was supported in part by the Yonsei UniversityWonju Campus
   Future-Leading Research Initiative of 2019-52-0052.
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NR 65
TC 11
Z9 13
U1 6
U2 24
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD MAR
PY 2021
VL 18
IS 5
AR 2242
DI 10.3390/ijerph18052242
PG 19
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA QV7UD
UT WOS:000628170600001
PM 33668309
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Benetó, A
   Gomez-Siurana, E
   Rubio-Sanchez, P
AF Beneto, Antonio
   Gomez-Siurana, Enriqueta
   Rubio-Sanchez, Pilar
TI Comorbidity between sleep apnea and insomnia
SO SLEEP MEDICINE REVIEWS
LA English
DT Review
DE Sleep apnea; Obstructive sleep apnea; Insomnia; Comorbidity;
   Hypothalamic-pituitary-adrenal axis; Metabolic syndrome
ID EXCESSIVE DAYTIME SLEEPINESS; UPPER AIRWAY COLLAPSIBILITY;
   PUBLIC-HEALTH; METABOLIC SYNDROME; FRAGMENTATION; ASSOCIATION;
   DEPRIVATION; SYMPTOMS; VENTILATION; DEPRESSION
AB The association between insomnia and sleep apnea has received little attention from health professionals in the past few decades. However, recent Studies have shown a high prevalence of insomnia complaints in patients with objectively diagnosed obstructive sleep apnea (OSA) syndrome. In this paper we have reviewed data published on different aspects of this association: the clinical profile of sleep-disordered breathing (SDB)-plus, the nature of the association, the role in the onset of insomnia played by OSA itself and other comorbidity factors such as depression or the restless leg syndrome. Finally, we have reviewed data and hypotheses on the metabolic implications of OSA and insomnia, and we speculate on the role that hypothalamic-pituitary-adrenal axis hyperactivity may play in a hypothetical interrelation between OSA and insomnia. The apparent paradox implied by this clinical association reveals the need for interdisciplinary training for physicians who treat both types of disorders. (C) 2008 Elsevier Ltd. All rights reserved.
C1 [Beneto, Antonio; Gomez-Siurana, Enriqueta; Rubio-Sanchez, Pilar] Hosp Univ La Fe, Serv Neurofisiol, Unidad Sueno, Valencia 46009, Spain.
C3 Hospital Universitari i Politecnic La Fe
RP Benetó, A (corresponding author), Hosp Univ La Fe, Serv Neurofisiol, Unidad Sueno, Ave Campanar 21, Valencia 46009, Spain.
EM beneto_ant@gva.es; gomez_enrsiu@gva.es; rubio_pil@gva.es
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NR 60
TC 119
Z9 126
U1 0
U2 11
PU W B SAUNDERS CO LTD
PI LONDON
PA 32 JAMESTOWN RD, LONDON NW1 7BY, ENGLAND
SN 1087-0792
EI 1532-2955
J9 SLEEP MED REV
JI Sleep Med. Rev.
PD AUG
PY 2009
VL 13
IS 4
BP 287
EP 293
DI 10.1016/j.smrv.2008.09.006
PG 7
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 476GP
UT WOS:000268427300006
PM 19246219
DA 2025-06-11
ER

PT J
AU Ziolkowska, S
   Binienda, A
   Jablkowski, M
   Szemraj, J
   Czarny, P
AF Ziolkowska, Sylwia
   Binienda, Agata
   Jablkowski, Maciej
   Szemraj, Janusz
   Czarny, Piotr
TI The Interplay between Insulin Resistance, Inflammation, Oxidative
   Stress, Base Excision Repair and Metabolic Syndrome in Nonalcoholic
   Fatty Liver Disease
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE nonalcoholic fatty liver disease; insulin resistance; inflammation; DNA
   repair; oxidative stress; base excision repair; metabolic syndrome
ID ENDOPLASMIC-RETICULUM STRESS; UNFOLDED PROTEIN RESPONSE; TYPE-2
   DIABETES-MELLITUS; IMPROVES HEPATIC STEATOSIS; DE-NOVO LIPOGENESIS;
   NF-KAPPA-B; DNA-DAMAGE; TRIGLYCERIDE SYNTHESIS; TRANSCRIPTION FACTOR;
   ADIPOSE-TISSUE
AB One of the most common chronic liver disorders, affecting mainly people in Western countries, is nonalcoholic fatty liver disease (NAFLD). Unfortunately, its pathophysiological mechanism is not fully understood, and no dedicated treatment is available. Simple steatosis can lead to nonalcoholic steatohepatitis and even to fibrosis, cancer, and cirrhosis of the liver. NAFLD very often occurs in parallel with type 2 diabetes mellitus and in obese people. Furthermore, it is much more likely to develop in patients with metabolic syndrome (MS), whose criteria include abdominal obesity, elevated blood triacylglycerol level, reduced high-density lipoprotein cholesterol level, increased blood pressure, and high fasting glucose. An important phenomenon in MS is also insulin resistance (IR), which is very common in NAFLD. Liver IR and NAFLD development are linked through an interaction between the accumulation of free fatty acids, hepatic inflammation, and increased oxidative stress. The liver is particularly exposed to elevated levels of reactive oxygen species due to a large number of mitochondria in hepatocytes. In these organelles, the main DNA repair pathway is base excision repair (BER). The present article will illustrate how impairment of BER may be related to the development of NAFLD.
C1 [Ziolkowska, Sylwia; Szemraj, Janusz; Czarny, Piotr] Med Univ Lodz, Dept Med Biochem, PL-92215 Lodz, Poland.
   [Binienda, Agata] Med Univ Lodz, Dept Biochem, Fac Med, PL-92215 Lodz, Poland.
   [Jablkowski, Maciej] Med Univ Lodz, Dept Infect & Liver Dis, PL-91347 Lodz, Poland.
C3 Medical University Lodz; Medical University Lodz; Medical University
   Lodz
RP Ziolkowska, S (corresponding author), Med Univ Lodz, Dept Med Biochem, PL-92215 Lodz, Poland.
EM sylwia.ziolkowska@umed.lodz.pl; agata.binienda@stud.umed.lodz.pl;
   maciej.jablkowski@umed.lodz.pl; janusz.szemraj@umed.lodz.pl;
   piotr.czarny@umed.lodz.pl
RI Czarny, Piotr/S-9539-2016; Binienda, Agata/HIK-3703-2022
OI Binienda, Agata/0000-0002-1173-2966; Ziolkowska,
   Sylwia/0000-0001-8140-3853; Szemraj, Janusz/0000-0001-6052-3557; Czarny,
   Piotr/0000-0002-5146-5225; Jablkowski, Maciej/0000-0002-3661-6777
FU National Science Centre [2019/35/O/NZ5/02502]
FX FundingThe APC was funded by National Science Centre
   (2019/35/O/NZ5/02502).
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NR 255
TC 101
Z9 106
U1 5
U2 39
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD OCT
PY 2021
VL 22
IS 20
AR 11128
DI 10.3390/ijms222011128
PG 27
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA WR8QM
UT WOS:000714759600001
PM 34681787
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Alshiddi, IF
   Habib, SR
   Sattar, K
   Alshahrani, A
   Almufleh, RS
   Basuhail, S
   Andejani, A
AF Alshiddi, Ibraheem F.
   Habib, Syed Rashid
   Sattar, Kamran
   Alshahrani, Abdullah
   Almufleh, Rya S.
   Basuhail, Suhailah
   Andejani, Abdulelah
TI Are dentists more prone to metabolic syndrome and occupational stress?
SO WORK-A JOURNAL OF PREVENTION ASSESSMENT & REHABILITATION
LA English
DT Article
DE Dentists; metabolic syndrome; occupational stress; occupational health;
   physical activity
ID 3RD NATIONAL-HEALTH; CARDIOVASCULAR-DISEASE; WORK STRESS; RISK;
   PREVALENCE; POPULATION; OBESITY; ASIA; ADULTS; MEN
AB OBJECTIVE: The aim of this studywas to investigate the prevalence of metabolic syndrome (MS) among dentists in Riyadh, Saudi Arabia. The study also explored the causes of occupational stress among the participating dentists.
   MATERIALS & METHODS: The participants included a conveniently selected sample of dentists (N= 126; Males = 65; Females = 61). The participants' anthropometric measurements/blood sample analysis were carried out and they completed a self-administered questionnaire. Data analysis included demographics, gender/age wise comparison using SPSS (p < 0.05). For the diagnosis of MS, updated criteria of the National Cholesterol Education Program was applied.
   RESULTS: Participants diagnosed with MS were 13 (10.3%), Males = 11(8.7%) and Females = 2(1.5%). Physical activity of 6 (15.8%) with MS was only 0-2 hours/week. 9 (14.5%) participants with MS declared positive family history for MS. The average systolic (117.55 +/- 11.33) and diastolic blood pressure (71.9 +/- 9.34) of the participants was found to be normal with no gender wise statistical difference. No gender wise statistical differences (p > 0.05) were observed for cholesterol, triglycerides and HDL. However, significant difference (p = 0.00) was found for the fasting glucose level (Males = 5.69 +/- 1.49; Females = 4.94 +/- 0.42). Overall mean scoring (3.00 +/- 1.11) for the stress showed that the participants fall into the average/moderate level of stress category (Males = 3.16 +/- 1.02; Females = 2.83 +/- 1.08). Almost two third (68.26%) of the participant's responded that they were under some kind of stress.
   CONCLUSIONS: MS was found to be less frequent among the dentists working in the city of Riyadh. Overall, the dentists were under moderate level of occupational stress, with male dentists being more prone to work related stress.
C1 [Alshiddi, Ibraheem F.; Habib, Syed Rashid; Alshahrani, Abdullah] King Saud Univ, Coll Dent, Dept Prosthet Dent Sci, POB 60169,King Abdullah Rd, Riyadh 11545, Saudi Arabia.
   [Sattar, Kamran] Univ Sains Malaysia, Sch Med Sci, Dept Med Educ, Kubang Kerian, Kelantan, Malaysia.
   [Almufleh, Rya S.] Saudi Board Pediat Dent, Riyadh, Saudi Arabia.
   [Basuhail, Suhailah] Douvin Med Ctr, Riyadh, Saudi Arabia.
   [Andejani, Abdulelah] King Saud Bin Abdulaziz Univ Hlth Sci, Dept Prosthodont, Riyadh, Saudi Arabia.
C3 King Saud University; Universiti Sains Malaysia; King Saud Bin Abdulaziz
   University for Health Sciences
RP Habib, SR (corresponding author), King Saud Univ, Coll Dent, Dept Prosthet Dent Sci, POB 60169,King Abdullah Rd, Riyadh 11545, Saudi Arabia.
EM syhabib@ksu.edu.sa
RI , KAMRAN/R-1298-2017; Alshahrani, Abdullah/LQK-9226-2024; Habib,
   Syed/G-1440-2017
FU College of Dentistry Research Center (CDRC) at King Saud University;
   Deanship of Scientific Research at King Saud University
FX The authors are thankful to the participating dentists for their
   participation and time. The authors also are thankful to Mr. Nasr
   Maflehi for helping in the statistical analysis. The research project
   was approved by the institutional review board of King Saud University
   Medical City (Reg #H-01-R-002). The study was funded and supported by
   College of Dentistry Research Center (CDRC) and Deanship of Scientific
   Research at King Saud University.
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NR 46
TC 0
Z9 0
U1 0
U2 0
PU IOS PRESS
PI AMSTERDAM
PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS
SN 1051-9815
EI 1875-9270
J9 WORK
JI Work
PY 2021
VL 70
IS 4
BP 1187
EP 1194
DI 10.3233/WOR-205134
PG 8
WC Public, Environmental & Occupational Health
WE Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA XU8JX
UT WOS:000734505400018
PM 34842205
DA 2025-06-11
ER

PT J
AU Du, D
   Shi, YH
   Le, GW
AF Du, Dan
   Shi, Yong-Hui
   Le, Guo-Wei
TI Oxidative stress induced by high-glucose diet in liver of C57BL/6J mice
   and its underlying mechanism
SO MOLECULAR BIOLOGY REPORTS
LA English
DT Article
DE C57BL/6J mice; DNA microarray; High-glucose diet; Insulin resistance
   index; Oxidative stress; Real-time RT-PCR
ID PROLIFERATOR-ACTIVATED RECEPTOR; LIPID PEROXIDES; GLYCEMIC INDEX; ALPHA;
   METALLOTHIONEIN; GENERATION; RISK; LOAD
AB High glycemic index diet can induce multiple diseases. Many research indicated that oxidative stress played important role in many pathological conditions. However, the impact of gene expression and dietary habit on oxidation process are still less clear. We used high-glucose diet to feed C57BL/6J mice for 4 weeks, measured the redox status, physiological and biochemical changes related to diabetes and consequence of metabolic syndrome (nonalcoholic fatty liver, cardiovascular disease), and detected the expressions of 14,446 genes in liver of C57BL/6J mice with DNA microarray. The results showed high-glucose diet induced elevated fatty acid accumulation in liver, insulin resistance index and higher weight in C57BL/6J mice, which indicated high-glucose diet caused to the initiation and development of diabetes and consequence of metabolic syndrome. The results also showed high-glucose diet induced oxidative stress in liver of C57BL/6J mice, which might the cause of initiation and development of diabetes and consequence of metabolic syndrome. Microarray analysis found expressions of genes related to thiol redox, fatty acid oxidation in peroxisome and cytochrome P450 were significantly changed, indicating system in which non-enzyme antioxidant capacity was impaired and sources from which reactive oxygen species (ROS) generated, which revealed the molecular mechanism of oxidative stress induced by high-glucose diet. We validated our microarray findings by conducting real-time RT-PCR assays on selected genes.
C1 [Du, Dan; Shi, Yong-Hui; Le, Guo-Wei] Jiangnan Univ, State Key Lab Food Sci & Technol, Wuxi 214122, Jiangsu Prov, Peoples R China.
C3 Jiangnan University
RP Le, GW (corresponding author), Jiangnan Univ, State Key Lab Food Sci & Technol, 1800 Lihu Rd, Wuxi 214122, Jiangsu Prov, Peoples R China.
EM lgw@jiangnan.edu.cn
RI SHI, YH/HLG-1159-2023
FU National Natural Science Foundation of China [30571347]
FX This work was supported by National Natural Science Foundation of China
   (No. 30571347).
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NR 33
TC 27
Z9 28
U1 0
U2 15
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0301-4851
EI 1573-4978
J9 MOL BIOL REP
JI Mol. Biol. Rep.
PD DEC
PY 2010
VL 37
IS 8
BP 3833
EP 3839
DI 10.1007/s11033-010-0039-9
PG 7
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 672IV
UT WOS:000283577400023
PM 20217240
DA 2025-06-11
ER

PT J
AU Ulus, T
   Parspour, A
   Cavusoglu, Y
   Entok, E
   Uslu, I
   Demirustu, C
AF Ulus, T.
   Parspour, A.
   Cavusoglu, Y.
   Entok, E.
   Uslu, I.
   Demirustu, C.
TI Statins improve myocardial perfusion in metabolic syndrome patients who
   have perfusion defects on myocardial perfusion imaging and
   angiographically normal coronary arteries
SO EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
LA English
DT Article
DE Metabolic syndrome; Statins; Myocardial perfusion
ID EMISSION COMPUTED-TOMOGRAPHY; NITRIC-OXIDE SYNTHASE; ENDOTHELIAL
   DYSFUNCTION; CARDIOVASCULAR-DISEASE; REACTIVE HYPEREMIA; OXIDATIVE
   STRESS; FLOW RESERVE; BLOOD-FLOW; THERAPY; RISK
AB Objective: Previous studies in hypercholesterolemic patients with coronary artery disease (CAD) have demonstrated that lipid lowering therapy restores coronary endothelium dependent vasodilatation and increases myocardial perfusion. However, there is not enough data showing the effects of statins on myocardial perfusion in metabolic syndrome (MetS) patients who have perfusion abnormalities but not evident CAD, which are attributed to microvascular dysfunction. We aimed to evaluate whether or not statin therapy improves myocardial perfusion, as assessed by Technetium (Tc)-99m single-photon emission computed tomography (SPECT), in patients with MetS and angiographically normal epicardial coronary anatomy.
   Materials and Methods: The study population consisted of 55 selected patients (mean age: 52, 72% female) with MetS who have perfusion defect on exercise stress Tc-99m SPECT and normal coronary arteries. Patients were treated with 20 mg atorvastatin for six months regardless of baseline lipid levels and SPECT study was repeated after the therapy. The summed stress score (SSS), summed rest score (SRS) and summed difference score (SDS), and left ventricular (LV) volumes and ejection fractions (EF) at rest and stress were obtained.
   Results: We found significant improvements in SSS, SRS and SDS after six months of statin therapy (p=0.001, 0.001 and 0.002, respectively). In addition, end-diastolic volumes at rest and stress, and stroke volume at rest were significantly decreased (p = 0.001, 0.001 and 0.026, respectively). Also, LV EF at stress was significantly increased (p = 0.035).
   Conclusions: Statin therapy in patients with MetS who have perfusion defects on Tc-99m SPECT and normal coronary arteries produces significant improvements in myocardial perfusion abnormalities.
C1 [Ulus, T.; Parspour, A.; Cavusoglu, Y.] Eskisehir Osmangazi Univ, Dept Cardiol, Fac Med, Eskisehir, Turkey.
   [Entok, E.; Uslu, I.] Eskisehir Osmangazi Univ, Dept Nucl Med, Fac Med, Eskisehir, Turkey.
   [Demirustu, C.] Eskisehir Osmangazi Univ, Dept Biostat, Fac Med, Eskisehir, Turkey.
C3 Eskisehir Osmangazi University; Eskisehir Osmangazi University;
   Eskisehir Osmangazi University
RP Ulus, T (corresponding author), Eskisehir Osmangazi Univ, Dept Cardiol, Fac Med, Eskisehir, Turkey.
EM tanerulus@hotmail.com
RI Cavusoglu, Yuksel/JWA-0879-2024; entok, emre/AAB-9836-2022
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NR 40
TC 8
Z9 8
U1 0
U2 5
PU VERDUCI PUBLISHER
PI ROME
PA VIA GREGORIO VII, ROME, 186-00165, ITALY
SN 1128-3602
J9 EUR REV MED PHARMACO
JI Eur. Rev. Med. Pharmacol. Sci.
PD MAR
PY 2012
VL 16
IS 3
BP 328
EP 334
PG 7
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 926RQ
UT WOS:000302849100007
PM 22530349
DA 2025-06-11
ER

PT J
AU Im, S
   Kang, S
   Kim, JH
   Oh, SJ
   Pak, YK
AF Im, Suyeol
   Kang, Sora
   Kim, Ji Hwan
   Oh, Seung Jun
   Pak, Youngmi Kim
TI Low-Dose Dioxin Reduced Glucose Uptake in C2C12 Myocytes: The Role of
   Mitochondrial Oxidative Stress and Insulin-Dependent Calcium
   Mobilization
SO ANTIOXIDANTS
LA English
DT Article
DE environmental toxins; muscle glucose uptake; mitochondrial dysfunction;
   insulin signal transduction; oxidative stress
ID PERSISTENT ORGANIC POLLUTANTS; ENVIRONMENTAL DISRUPTION; GLUT4
   TRANSLOCATION; RYANODINE RECEPTOR; METABOLIC SYNDROME; MUSCLE-CELLS;
   AH-RECEPTOR; WEIGHT-LOSS; RESISTANCE; DYSFUNCTION
AB Chronic exposure to some environmental polluting chemicals (EPCs) is strongly associated with metabolic syndrome, and insulin resistance is a major biochemical abnormality in the skeletal muscle in patients with metabolic syndrome. However, the causal relationship is inconsistent and little is known about how EPCs affect the insulin signaling cascade in skeletal muscle. Here, we investigated whether exposure to 100 pM of 2,3,7,8-tetrachlorodibenzodioxin (TCDD) as a low dose of dioxin induces insulin resistance in C2C12 myocytes. The treatment with TCDD inhibited the insulin-stimulated glucose uptake and translocation of glucose transporter 4 (GLUT4). The low-dose TCDD reduced the expression of insulin receptor beta (IR beta) and insulin receptor substrate (IRS)-1 without affecting the phosphorylation of Akt. The TCDD impaired mitochondrial activities, leading to reactive oxygen species (ROS) production and the blockage of insulin-induced Ca2+ release. All TCDD-mediated effects related to insulin resistance were still observed in aryl hydrocarbon receptor (AhR)-deficient myocytes and prevented by MitoTEMPO, a mitochondria-targeting ROS scavenger. These results suggest that low-dose TCDD stress may induce muscle insulin resistance AhR-independently and that mitochondrial oxidative stress is a novel therapeutic target for dioxin-induced insulin resistance.
C1 [Im, Suyeol; Kim, Ji Hwan; Oh, Seung Jun; Pak, Youngmi Kim] Kyung Hee Univ, Grad Sch, Dept Biomed Sci, Seoul 02447, South Korea.
   [Kang, Sora; Pak, Youngmi Kim] Kyung Hee Univ, Grad Sch, Dept Neurosci, Seoul 02447, South Korea.
   [Pak, Youngmi Kim] Kyung Hee Univ, Sch Med, Biomed Sci Inst CRI, Dept Physiol, Seoul 02447, South Korea.
C3 Kyung Hee University; Kyung Hee University; Kyung Hee University
RP Pak, YK (corresponding author), Kyung Hee Univ, Grad Sch, Dept Biomed Sci, Seoul 02447, South Korea.; Pak, YK (corresponding author), Kyung Hee Univ, Grad Sch, Dept Neurosci, Seoul 02447, South Korea.; Pak, YK (corresponding author), Kyung Hee Univ, Sch Med, Biomed Sci Inst CRI, Dept Physiol, Seoul 02447, South Korea.
EM ykpak@khu.ac.kr
RI Pak, Youngmi/AAI-1091-2020
OI Kim, Ji Hwan/0000-0002-9780-1001; Pak, Youngmi/0000-0001-7424-3484
FU Basic Science Research Program through the National Research Foundation
   of Korea (NRF) - Korean government (MSIT) [2018R1A6A1A03025124,
   2020R1A2C1008699]
FX This research was supported by the Basic Science Research Program (Core
   Research Institute Program 2018R1A6A1A03025124 and 2020R1A2C1008699)
   through the National Research Foundation of Korea (NRF) funded by the
   Korean government (MSIT). The funding source had no role in the
   collection of data or in the decision to submit this manuscript for
   publication.
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NR 70
TC 7
Z9 7
U1 1
U2 12
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD NOV
PY 2022
VL 11
IS 11
AR 2109
DI 10.3390/antiox11112109
PG 22
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA 6A5GT
UT WOS:000880684700001
PM 36358481
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Yadav, R
   Yadav, RK
   Khadgawat, R
   Pandey, RM
AF Yadav, Rashmi
   Yadav, Raj Kumar
   Khadgawat, Rajesh
   Pandey, Ravindra Mohan
TI Comparative efficacy of a 12 week yoga-based lifestyle intervention and
   dietary intervention on adipokines, inflammation, and oxidative stress
   in adults with metabolic syndrome: a randomized controlled trial
SO TRANSLATIONAL BEHAVIORAL MEDICINE
LA English
DT Article
DE Yoga; Diet; Metabolic syndrome; Adipokines; Inflammation; Oxidative
   stress
ID WEIGHT-LOSS; CARDIOVASCULAR-DISEASE; RISK-FACTORS; SYNDROME REDUCTION;
   PLASMA LEPTIN; OBESE WOMEN; ADIPONECTIN; EXERCISE; OVERWEIGHT; IMPACT
AB The present randomized controlled trial (RCT) evaluated the comparative efficacy of 12 week yoga-based lifestyle intervention (YBLI) and dietary intervention (DI) alone on adipokines, inflammation, and oxidative stress in Indian adults with metabolic syndrome (Met S). A parallel, two arm, RCT was conducted in Integral Health Clinic (IHC), All India Institute of Medical Sciences, India from 2012 to 2014. IHC is an outpatient facility conducting YBLI programs for prevention and management of chronic diseases. Two hundred sixty men and women (20-45 years) visiting the outpatient department of a tertiary care hospital were diagnosed with Met S and randomized 1:1 to receive 12 week YBLI (n = 130) or DI (n = 130). Primary outcomes were change in plasma levels of adipokines (leptin, adiponectin, and leptin:adiponectin ratio), markers of inflammation (tumor necrosis factor [TNF]-alpha, interleukin [IL]-6), markers of oxidative stress (thiobarbituric acid reactive substances [TBARS], 8-hydroxy-2'-deoxyguanosine [8-OHdG], and superoxide dismutase [SOD]) measured at baseline, 2 weeks, and 12 weeks. YBLI group showed a significant decrease in leptin, leptin:adiponectin ratio, IL-6, 8-OHdG, and TBARS levels, whereas there was a significant increase in adiponectin and SOD levels. No significant changes were noticed in DI alone group. YBLI showed significantly greater reduction in TBARS levels than in DI group, suggestive of reduced oxidative stress in adults with Met S. A 12 week YBLI had a positive impact on oxidative stress versus DI alone in adults with Met S.
C1 [Yadav, Rashmi; Yadav, Raj Kumar] All India Inst Med Sci, Dept Physiol, New Delhi 110029, India.
   [Khadgawat, Rajesh] All India Inst Med Sci, Dept Endocrinol & Metab, New Delhi 110029, India.
   [Pandey, Ravindra Mohan] All India Inst Med Sci, Dept Biostat, New Delhi 110029, India.
C3 All India Institute of Medical Sciences (AIIMS) New Delhi; All India
   Institute of Medical Sciences (AIIMS) New Delhi; All India Institute of
   Medical Sciences (AIIMS) New Delhi
RP Yadav, RK (corresponding author), All India Inst Med Sci, Dept Physiol, New Delhi 110029, India.
EM raj3kr@gmail.com
RI Yadav, Rashmi/KYQ-5551-2024; Yadav, Raj Kumar/AFT-0686-2022
OI Yadav, Raj Kumar/0000-0002-5066-7028
FU Department of Physiology, AIIMS, New Delhi
FX Participants who volunteered to participate in this study are sincerely
   acknowledged. Authors extend their sincere thanks to Amit Tomar (Yoga
   Instructor) and Pragati Pragya (Dietician) for providing yoga training
   and dietary advice to study participants, respectively. Authors
   acknowledge grant provided by Department of Physiology, AIIMS, New
   Delhi, for financial support for the ELISA kits. Authors also extend
   their thanks to Ashish Datt Upadhyay for Statistical analysis.
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NR 56
TC 37
Z9 39
U1 0
U2 13
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1869-6716
EI 1613-9860
J9 TRANSL BEHAV MED
JI Transl. Behav. Med.
PD AUG
PY 2019
VL 9
IS 4
BP 594
EP 604
DI 10.1093/tbm/iby060
PG 11
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA JH7SF
UT WOS:000492967600003
PM 30020512
OA Bronze
DA 2025-06-11
ER

PT J
AU Perez-Martinez, P
   Garcia-Quintana, JM
   Yubero-Serrano, EM
   Tasset-Cuevas, I
   Tunez, I
   Garcia-Rios, A
   Delgado-Lista, J
   Marin, C
   Perez-Jimenez, F
   Roche, HM
   Lopez-Miranda, J
AF Perez-Martinez, Pablo
   Maria Garcia-Quintana, Jose
   Yubero-Serrano, Elena M.
   Tasset-Cuevas, Inmaculada
   Tunez, Isaac
   Garcia-Rios, Antonio
   Delgado-Lista, Javier
   Marin, Carmen
   Perez-Jimenez, Francisco
   Roche, Helen M.
   Lopez-Miranda, Jose
TI Postprandial oxidative stress is modified by dietary fat: evidence from
   a human intervention study
SO CLINICAL SCIENCE
LA English
DT Article
DE dietary fat; LIPGENE study; metabolic syndrome; oxidative stress;
   postprandial lipaemia
ID METABOLIC SYNDROME; MEDITERRANEAN DIET; QUANTITATIVE-DETERMINATION;
   EXERCISE INTERVENTION; SUPEROXIDE-DISMUTASE; FREE-RADICALS; ASSAY;
   GLUTATHIONE; PROTECTION; INSULIN
AB Previous evidence supports the concept that increased oxidative stress may play an important role in MetS (metabolic syndrome)-related manifestations. Dietary fat quality has been proposed to be critical in oxidative stress and the pathogenesis of the MetS. In the present study, we investigated whether oxidative stress parameters are affected by diets with different fat quantity and quality during the postprandial state in subjects with the MetS. Patients were randomly assigned to one of four isoenergetic diets distinct in fat quantity and quality for 12 weeks: a high-saturated-fatty-acid (HSFA) diet, a high-mono-unsaturated-fatty-acid (HMUFA) diet and two low-fat/high-complex carbohydrate diets [supplemented with 1.24 g/day of long-chain n-3 polyunsaturated fatty acid (LFHCC n-3) or with 1 g/day of sunflower oil high in oleic acid (LFHCC) as placebo]. The HMUFA diet enhanced postprandial GSH (reduced glutathione) levels and the GSH/GSSH (oxidized glutathione) ratio, compared with the other three diets. In addition, after the HMUFA-rich diet postprandial lipid peroxide levels, protein carbonyl concentrations, SOD (superoxide dismutase) activity and plasma H2O2 levels were lower compared with subjects adhering to the HSFA-rich diet. Both LFHCC diets had an intermediate effect relative to the HMUFA and HSFA diets. In conclusion, our data support the notion that the HMUFA diet improves postprandial oxidative stress in patients with the MetS. These findings suggest that the postprandial state is important for understanding the possible cardioprotective effects associated with mono-unsaturated dietary fat, particularly in subjects with the MetS.
C1 [Perez-Martinez, Pablo; Maria Garcia-Quintana, Jose; Yubero-Serrano, Elena M.; Garcia-Rios, Antonio; Delgado-Lista, Javier; Marin, Carmen; Perez-Jimenez, Francisco; Lopez-Miranda, Jose] Univ Cordoba & Ciber Fisiopatol Obesidad & Nutr, Lipids & Atherosclerosis Unit, Inst Maimonides Invest Biomed Cordoba IMIBIC, Hosp Univ Reina Sofia,Inst Salud Carlos 3, Cordoba 14004, Spain.
   [Tasset-Cuevas, Inmaculada; Tunez, Isaac] Univ Cordoba & Ciber Fisiopatol Obesidad & Nutr, Dept Biochem & Mol Biol, Inst Maimonides Invest Biomed Cordoba IMIBIC, Hosp Univ Reina Sofia,Fac Med, Cordoba 14004, Spain.
   [Roche, Helen M.] Univ Coll Dublin, Nutrigenom Res Grp, Sch Publ Hlth & Populat Sci, UCD Conway Inst, Dublin 4, Ireland.
C3 CIBER - Centro de Investigacion Biomedica en Red; CIBEROBN; Hospital
   Universitario Reina Sofia - Cordoba; Hospital Universitario Reina Sofia
   - Cordoba; CIBER - Centro de Investigacion Biomedica en Red; CIBEROBN;
   University College Dublin
RP Lopez-Miranda, J (corresponding author), Univ Cordoba & Ciber Fisiopatol Obesidad & Nutr, Lipids & Atherosclerosis Unit, Inst Maimonides Invest Biomed Cordoba IMIBIC, Hosp Univ Reina Sofia,Inst Salud Carlos 3, Cordoba 14004, Spain.
EM jlopezmir@uco.es
RI Delgado-Lista, Javier/KAM-7412-2024; Roche, Helen/AAF-4164-2019;
   Lopez-Miranda, Jose/Y-8306-2019; Cuevas, Inmaculada/R-4509-2019; Marin
   Hinojosa, Carmen/AFO-1294-2022; Yubero-Serrano, Elena/H-4832-2013;
   Jimenez, Francisco/AAJ-9559-2021; Tejada, Silvia/L-7297-2014; Perez
   Martinez, Pablo/AEL-6176-2022
OI Perez-Jimenez, Francisco/0000-0001-7499-7681; Roche,
   Helen/0000-0002-0628-3318; Lopez-Miranda, Jose/0000-0002-8844-0718;
   Perez Jimenez, Francisco/0000-0001-9808-1280; Delgado Lista, Francisco
   Javier/0000-0002-2982-2716; Yubero-Serrano, Elena M/0000-0002-2733-5359;
   Perez Martinez, Pablo/0000-0001-7716-8117
FU European Union [505944]; Ministerio de Ciencia e Innovacion [AGL
   2004-07907, AGL2006-01979, AGL2009-12270]; GIBER Fisiopatologia de la
   Obesidad y Nutricion [CB06/03/0047]; Consejeria de Innovacion; Ciencia y
   Empresa; Junta de Andalucia [P06-CTS-01425]; Consejeria de Salud, Junta
   de Andalucia [06/128,07/43, PI-0193]; Science Foundation Ireland
   [06/IM.1/B105]
FX This work was supported in part by research grants from the European
   Union [LIPGENE European Integrated Project-505944], from the Ministerio
   de Ciencia e Innovacion [grant numbers AGL 2004-07907, AGL2006-01979,
   AGL2009-12270 (to J.L.-M.)]; GIBER Fisiopatologia de la Obesidad y
   Nutricion [grant number CB06/03/0047]; Consejeria de Innovacion, Ciencia
   y Empresa, Junta de Andalucia [grant number P06-CTS-01425 (to J.L.-M.)];
   and Consejeria de Salud, Junta de Andalucia [grant numbers 06/128,07/43,
   PI-0193 (to J.L.M.)]. H.M.R. is a recipient of the Science Foundation
   Ireland Principal Investigator Programme [grant number 06/IM.1/B105].
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NR 52
TC 65
Z9 70
U1 0
U2 17
PU PORTLAND PRESS LTD
PI LONDON
PA 5TH FLR, 90 HIGH HOLBORN, LONDON WC1V 6LJ, ENGLAND
SN 0143-5221
EI 1470-8736
J9 CLIN SCI
JI Clin. Sci.
PD SEP
PY 2010
VL 119
IS 5-6
BP 251
EP 261
DI 10.1042/CS20100015
PG 11
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 653ZJ
UT WOS:000282137600007
PM 20420579
OA Green Published
DA 2025-06-11
ER

PT J
AU Nyawo, TA
   Pheiffer, C
   Mazibuko-Mbeje, SE
   Mthembu, SXH
   Nyambuya, TM
   Nkambule, BB
   Gijsen, HSV
   Strijdom, H
   Tiano, L
   Dludla, PV
AF Nyawo, Thembeka A.
   Pheiffer, Carmen
   Mazibuko-Mbeje, Sithandiwe E.
   Mthembu, Sinenhlanhla X. H.
   Nyambuya, Tawanda M.
   Nkambule, Bongani B.
   Sadie-Van Gijsen, Hanel
   Strijdom, Hans
   Tiano, Luca
   Dludla, Phiwayinkosi V.
TI Physical Exercise Potentially Targets Epicardial Adipose Tissue to
   Reduce Cardiovascular Disease Risk in Patients with Metabolic Diseases:
   Oxidative Stress and Inflammation Emerge as Major Therapeutic Targets
SO ANTIOXIDANTS
LA English
DT Review
DE epicardial adipose tissue; oxidative stress; inflammation;
   cardiovascular disease; exercise; physical activity
ID FAT THICKNESS; AEROBIC EXERCISE; ENDOTHELIAL-CELL; HEART; DYSFUNCTION;
   MECHANISMS; OBESITY; DIET; ATHEROSCLEROSIS; INTERLEUKIN-6
AB Excess epicardial adiposity, within a state of obesity and metabolic syndrome, is emerging as an important risk factor for the development of cardiovascular diseases (CVDs). Accordingly, increased epicardial fat thickness (EFT) implicates the exacerbation of pathological mechanisms involving oxidative stress and inflammation within the heart, which may accelerate the development of CVDs. This explains increased interest in targeting EFT reduction to attenuate the detrimental effects of oxidative stress and inflammation within the setting of metabolic syndrome. Here, we critically discuss clinical and preclinical evidence on the impact of physical exercise on EFT in correlation with reduced CVD risk within a setting of metabolic disease. This review also brings a unique perspective on the implications of oxidative stress and inflammation as major pathological consequences that link increased EFT to accelerated CVD risk in conditions of metabolic disease.
C1 [Nyawo, Thembeka A.; Pheiffer, Carmen; Mthembu, Sinenhlanhla X. H.; Dludla, Phiwayinkosi V.] South African Med Res Council, Biomed Res & Innovat Platform, ZA-7505 Cape Town, South Africa.
   [Nyawo, Thembeka A.; Pheiffer, Carmen; Sadie-Van Gijsen, Hanel; Strijdom, Hans] Stellenbosch Univ, Div Med Physiol, Fac Med & Hlth Sci, Ctr Cardiometabol Res Africa CARMA, ZA-7505 Cape Town, South Africa.
   [Pheiffer, Carmen] Univ Pretoria, Dept Obstet & Gynaecol, Fac Hlth Sci, ZA-0001 Pretoria, South Africa.
   [Mazibuko-Mbeje, Sithandiwe E.; Mthembu, Sinenhlanhla X. H.] Northwest Univ, Dept Biochem, Mafikeng Campus, ZA-2735 Mmabatho, South Africa.
   [Nyambuya, Tawanda M.] Namibia Univ Sci & Technol, Fac Hlth & Appl Sci, Dept Hlth Sci, Windhoek 9000, Namibia.
   [Nkambule, Bongani B.] Univ Kwazulu Natal, Sch Lab Med & Med Sci, Coll Hlth Sci, ZA-4000 Durban, South Africa.
   [Tiano, Luca] Polytech Univ Marche, Dept Life & Environm Sci, I-60131 Ancona, Italy.
C3 South African Medical Research Council; Stellenbosch University;
   University of Pretoria; Namibia University of Science & Technology;
   University of Kwazulu Natal; Marche Polytechnic University
RP Dludla, PV (corresponding author), South African Med Res Council, Biomed Res & Innovat Platform, ZA-7505 Cape Town, South Africa.
EM thembeka.nyawo@mrc.ac.za; carmen.pheiffer@mrc.ac.za; 36588296@nwu.ac.za;
   sinenhlanhla.mthembu@mrc.ac.za; mnyambuya@nust.na; nkambuleb@ukzn.ac.za;
   hsadie@sun.ac.za; jgstr@sun.ac.za; l.tiano@univpm.it; pdludla@mrc.ac.za
RI Tiano, Luca/ABC-2341-2020; Mazibuko-Mbeje, Sithandiwe/HPG-1119-2023;
   Nkambule, Bongani/ABD-7943-2022; Nyambuya, Tawanda
   Maurice/GLU-4124-2022; Sadie-Van Gijsen, Hanél/AFZ-9395-2022
OI Sadie-Van Gijsen, Hanel/0000-0002-1745-563X; Pheiffer,
   Carmen/0000-0002-0707-1552; Dludla, Phiwayinkosi/0000-0001-5965-3610;
   Nkambule, Bongani/0000-0001-8846-1992; Strijdom,
   Hans/0000-0003-3726-9153; MTHEMBU, SINENHLANHLA/0000-0003-2747-1841;
   Nyambuya, Tawanda Maurice/0000-0002-3288-9524; Tiano,
   Luca/0000-0002-7519-7106
FU Biomedical Research and Innovation Platform of the South African Medical
   Research Council (SAMRC); National Research Foundation [117829]
FX This work was supported in part by baseline funding from the Biomedical
   Research and Innovation Platform of the South African Medical Research
   Council (SAMRC) and the National Research Foundation (Grant number:
   117829). The content hereof is the sole responsibility of the authors
   and does not necessarily represent the official views of the SAMRC or
   the funders.
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NR 88
TC 24
Z9 24
U1 3
U2 13
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD NOV
PY 2021
VL 10
IS 11
AR 1758
DI 10.3390/antiox10111758
PG 16
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA XG7PH
UT WOS:000724940500001
PM 34829629
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Belia, S
   Lupattelli, G
   Urbani, E
   Vaudo, G
   Roscini, AR
   Perni, S
   Marsili, V
AF Belia, Silvia
   Lupattelli, Graziana
   Urbani, Eleonora
   Vaudo, Gaetano
   Roscini, Anna Rita
   Perni, Stefano
   Marsili, Valeria
TI Oxidative Balance in Lymphocytes From Patients With Nonalcoholic
   Steatohepatitis
SO AMERICAN JOURNAL OF THE MEDICAL SCIENCES
LA English
DT Article
DE Oxidative stress; Lymphocytes; Metabolic syndrome; NAFLD; ROS
ID FATTY LIVER-DISEASE; MITOCHONDRIAL DYSFUNCTION; CARDIOVASCULAR-DISEASE;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; STRESS; ABNORMALITIES;
   ASSOCIATION; CALCIUM; ARTERY
AB Oxidative stress is linked to several human diseases, including nonalcoholic steatohepatitis (NASH). In this study, lymphocytes were used as a model to study this disease. These cells offer several advantages for cellular and molecular studies such as easy accessibility, and they are easily accessible and constitute a "time-persistent" system capable of reflecting the condition of the whole organism. Lymphocytes from patients with NASH display oxidative stress features. Among the possible causes for the overproduction of reactive oxygen species in NASH lymphocytes, there might be alterations of enzymatic pathways, auto-oxidation of glucose and mitochondrial superoxide production, which, in turn, would lead to protein oxidative damage. Increased oxidative stress in lymphocytes from patients with NASH may result in a pro-oxidative environment, which, in turn, could modify the pathway of the enzymatic activities. The data confirm that an imbalance between pro-oxidant and antioxidant defense mechanisms may be an important factor in NASH.
C1 [Belia, Silvia; Urbani, Eleonora; Perni, Stefano; Marsili, Valeria] Univ Perugia, Dept Cellular & Environm Biol, I-06123 Perugia, Italy.
   [Lupattelli, Graziana; Vaudo, Gaetano; Roscini, Anna Rita] Univ Perugia, Dept Clin & Expt Med Internal Med Angiol & Athero, I-06123 Perugia, Italy.
C3 University of Perugia; University of Perugia
RP Belia, S (corresponding author), Univ Perugia, Dept Cellular & Environm Biol, Via Elce Sotto, I-06123 Perugia, Italy.
EM fisio@unipg.it
RI Perni, Stefano/M-1925-2016; Vaudo, Gaetano/AAC-4823-2022
OI Perni, Stefano/0000-0002-0591-4376; Vaudo, Gaetano/0000-0002-3176-2038;
   urbani, eleonora/0000-0002-3328-2169
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NR 40
TC 3
Z9 3
U1 0
U2 11
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0002-9629
EI 1538-2990
J9 AM J MED SCI
JI Am. J. Med. Sci.
PD JUL
PY 2014
VL 348
IS 1
BP 30
EP 36
DI 10.1097/MAJ.0000000000000191
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA AK6HQ
UT WOS:000338529100002
PM 24949725
DA 2025-06-11
ER

PT J
AU Zhou, QG
   Zhou, M
   Lou, AJ
   Xie, D
   Hou, FF
AF Zhou, Qiu Gen
   Zhou, Min
   Lou, Ai Ju
   Xie, Di
   Hou, Fan Fan
TI Advanced Oxidation Protein Products Induce Inflammatory Response and
   Insulin Resistance in Cultured Adipocytes via Induction of Endoplasmic
   Reticulum Stress
SO CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
LA English
DT Article
DE Advanced oxidation protein products; Adipocyte; Inflammation; Insulin
   resistance; Endoplasmic reticulum stress; NADPH oxidase
ID NECROSIS-FACTOR-ALPHA; C-REACTIVE PROTEIN; NF-KAPPA-B; ADIPOSE-TISSUE;
   METABOLIC SYNDROME; NADPH OXIDASE; OBESITY; ATHEROSCLEROSIS;
   ACCUMULATION; ACTIVATION
AB Accumulation of advanced oxidation protein products (AOPPs) is prevalent in metabolic syndrome and type 2 diabetes. Adipocyte dysfunction has been recognized as a link between these conditions. To examine the effect of AOPPs on adipocyte perturbation, 3T3-L1 adipocytes were treated with increased levels of AOPPs as seen in these conditions. Exposure of adipocytes to AOPPs induced overexpression of tumor necrosis factor alpha and interleukin-6. This inflammatory response was completely blocked by nuclear factor-kappa B inhibitor SN50. AOPPs challenge also impaired insulin signaling, which was partly prevented by SN50. Treatment with AOPPs triggered endoplasmic reticulum (ER) stress, revealed by phosphorylation of PKR-like eukaryotic initiation factor 2 alpha kinase, eukaryotic translational initiation factor 2 alpha, inositol-requiring enzyme 1 and c-jun N-terminal kinase, and by overexpression of glucose regulated protein 78. AOPPs-induced ER stress was mediated by reactive oxygen species (ROS) generated by activation of NADPH oxidase since it was prevented by NADPH oxidase inhibitors or ROS scavenger. Treating the cells with inhibitors of NADPH oxidase or ER stress could completely abolish AOPPs-induced overexpression of adipocytokines and insulin resistance, suggesting that AOPPs induced adipocyte perturbation probably through induction of ROS-dependent ER stress. Our data identified AOPPs as a class of important mediator of adipocyte perturbation. Accumulation of AOPPs might be involved in adipocyte dysfunction as seen in metabolic syndrome and type 2 diabetes. Copyright (C) 2010 S. Karger AG, Basel
C1 [Hou, Fan Fan] So Med Univ, Div Nephrol, Nanfang Hosp, Guangzhou 510515, Guangdong, Peoples R China.
   Minist Educ, Key Lab Organ Failure Res, Guangzhou, Guangdong, Peoples R China.
C3 Southern Medical University - China; Ministry of Education - China
RP Hou, FF (corresponding author), So Med Univ, Div Nephrol, Nanfang Hosp, 1838 N Guangzhou Ave, Guangzhou 510515, Guangdong, Peoples R China.
EM ffhou@public.guangzhou.gd.cn
FU National Nature and Science Grant [30830056, U0932002, 81070613];
   National 973 Research Project [2006CB03904]; Nanfang Hospital [2008B015]
FX This work was supported by National Nature and Science Grant (No.
   30830056 and No. U0932002) and the National 973 Research Project (No.
   2006CB03904) to Dr F. F. Hou and National Nature and Science Grant (No.
   81070613) and President Grant of Nanfang Hospital (2008B015) to Dr. Q.
   G. Zhou.
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NR 58
TC 40
Z9 48
U1 0
U2 7
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1015-8987
EI 1421-9778
J9 CELL PHYSIOL BIOCHEM
JI Cell. Physiol. Biochem.
PY 2010
VL 26
IS 4-5
BP 775
EP 786
DI 10.1159/000322345
PG 12
WC Cell Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Physiology
GA 675TP
UT WOS:000283859000029
PM 21063115
DA 2025-06-11
ER

PT J
AU Takagi, T
   Hayashi, R
   Nakai, Y
   Okada, S
   Miyashita, R
   Yamada, M
   Mihara, Y
   Mizushima, K
   Morita, M
   Uchiyama, K
   Naito, Y
   Itoh, Y
AF Takagi, Tomohisa
   Hayashi, Ryotaro
   Nakai, Yuji
   Okada, Shinji
   Miyashita, Rumiko
   Yamada, Mayumi
   Mihara, Yoichi
   Mizushima, Katsura
   Morita, Mayuko
   Uchiyama, Kazuhiko
   Naito, Yuji
   Itoh, Yoshito
TI Dietary Intake of Carotenoid-Rich Vegetables Reduces Visceral Adiposity
   in Obese Japanese men-A Randomized, Double-Blind Trial
SO NUTRIENTS
LA English
DT Article
DE carotenoids; lycopene; lutein; visceral adiposity; metabolic syndrome
ID METABOLIC SYNDROME; OXIDATIVE STRESS; TOMATO PRODUCTS; HUMAN PLASMA;
   LYCOPENE; RISK; PREVENTION; DISEASE; LUTEIN; FRUIT
AB Metabolic syndrome, whose main diagnostic component is obesity, is a risk factor for lifestyle-related diseases, type 2 diabetes, and cardiovascular disease. Diet is known to affect the prevalence of metabolic syndrome. However, the effect of diet on metabolic syndrome in Japanese subjects has not been thoroughly explored. In the present study, we investigated the effect of carotenoid-rich vegetables, particularly lycopene- and lutein-rich vegetables, on the metabolic syndrome in obese Japanese men. We conducted an 8-week long randomized, double-blinded, controlled clinical trial in which, 28 middle-aged (40 <= age < 65) Japanese men with high body mass index (BMI >= 25) were randomized into four dietary groups: high lycopene + high lutein (HLyHLu), high lycopene + low lutein (HLyLLu), low lycopene + high lutein (LLyHLu), and low lycopene + low lutein (LLyLLu). Our results showed that daily beverage-intake increased the plasma levels of carotenoids without adverse effects, and the visceral fat level was significantly decreased in all the groups. The waist circumference was significantly decreased only in the HLyLLu group, whereas the CoQ10 oxidation rate was decreased in all the groups. The gene expression profiles of whole blood samples before and after ingestion differed only in the LLyLLu group, indicating the effect of carotenoids on gene expression profile. In conclusion, our results suggest that dietary uptake of carotenoid-rich vegetables increases their concentration in blood and reduces the intra-abdominal visceral fat.
C1 [Takagi, Tomohisa; Mizushima, Katsura; Uchiyama, Kazuhiko; Naito, Yuji; Itoh, Yoshito] Kyoto Prefectural Univ Med, Grad Sch Med Sci, Mol Gastroenterol & Hepatol, Kyoto 6028566, Japan.
   [Takagi, Tomohisa] Kyoto Prefectural Univ Med, Grad Sch Med Sci, Dept Med Innovat & Translat Med Sci, Kyoto 6028566, Japan.
   [Hayashi, Ryotaro; Miyashita, Rumiko] Nippon Flour Mills Co Ltd, Innovat Ctr, Atsugi, Kanagawa 2430041, Japan.
   [Nakai, Yuji] Hirosaki Univ, Inst Reg Innovat, Sect Food Sci, Aomori 0380012, Japan.
   [Okada, Shinji] Univ Tokyo, Grad Sch Agr & Life Sci, Tokyo 1138654, Japan.
   [Yamada, Mayumi] Natl Canc Ctr Hosp East, Clin Res Support Off, Kashiwa, Chiba 2778577, Japan.
   [Mihara, Yoichi] NK Med Co LTD, Tokyo 1050012, Japan.
   [Morita, Mayuko] Showa Gakuin Jr Coll, Hlth Care Nutr, Chiba 2720823, Japan.
C3 Kyoto Prefectural University of Medicine; Kyoto Prefectural University
   of Medicine; Hirosaki University; University of Tokyo; National Cancer
   Center - Japan
RP Takagi, T (corresponding author), Kyoto Prefectural Univ Med, Grad Sch Med Sci, Mol Gastroenterol & Hepatol, Kyoto 6028566, Japan.; Takagi, T (corresponding author), Kyoto Prefectural Univ Med, Grad Sch Med Sci, Dept Med Innovat & Translat Med Sci, Kyoto 6028566, Japan.
EM takatomo@koto.kpu-m.ac.jp; r-hayashi@nippn.co.jp;
   yunakai@hirosaki-u.ac.jp; asoka@mail.ecc.u-tokyo.ac.jp;
   miyashita@nippn.co.jp; mayyamad@east.ncc.go.jp;
   y.mihara@noritsu-koki.com; mizusima@koto.kpu-m.ac.jp;
   m-morita@koto.kpu-m.ac.jp; k-uchi@koto.kpu-m.ac.jp;
   ynaito@koto.kpu-m.ac.jp; yitoh@koto.kpu-m.ac.jp
RI NAKAI, Yuji/G-3433-2014; OKADA, Shinji/AFS-7710-2022
OI Naito, Yuji/0000-0001-5443-788X; Okada, Shinji/0000-0002-4465-9961;
   Takagi, Tomohisa/0000-0002-6119-4828
FU Research Project on Development of Agricultural Products and Foods with
   Health-promoting benefits (NARO), Japan [1341386];
   Industry-Academia-Government Collaboration of "Field for Knowledge
   Integration and Innovation" (FKII) from the Ministry of Agriculture,
   Forestry and Fisheries of Japan [16824414]
FX This work was supported by a grant (Project No. 1341386) received from
   the Research Project on Development of Agricultural Products and Foods
   with Health-promoting benefits (NARO), Japan, and a grant (Project No.
   16824414) received from the Industry-Academia-Government Collaboration
   of "Field for Knowledge Integration and Innovation" (FKII) from the
   Ministry of Agriculture, Forestry and Fisheries of Japan.
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NR 44
TC 15
Z9 15
U1 3
U2 18
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD AUG
PY 2020
VL 12
IS 8
AR 2342
DI 10.3390/nu12082342
PG 13
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA OA6LH
UT WOS:000577893600001
PM 32764462
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Rizvi, AA
AF Rizvi, Ali A.
TI Inflammation markers as mediators of vasculo-endothelial dysfunction and
   atherosclerosis in the metabolic syndrome and type 2 diabetes
SO CHINESE MEDICAL JOURNAL
LA English
DT Article
DE insulin resistance; inflammatory markers; diabetes; metabolic syndrome;
   endothelial dysfunction; obesity
ID C-REACTIVE PROTEIN; CORONARY-HEART-DISEASE; LOW-GRADE INFLAMMATION;
   TUMOR-NECROSIS-FACTOR; INSULIN-RESISTANCE; CARDIOVASCULAR-DISEASE;
   RISK-FACTORS; PLASMA-FIBRINOGEN; ADIPOSE-TISSUE; OBESITY
AB The prevalence of both type 2 diabetes and metabolic syndrome is increasing exponentially all over the world because of global changes in obesity, sedentary lifestyle, and the aging of the population.(1) The metabolic syndrome consists of a constellation of risk factors including obesity, glucose intolerance, hypertension, and dyslipidemia. Both metabolic syndrome and type 2 diabetes occur in the setting of insulin resistance and confer an increased risk of atherosclerosis and cardiovascular disease (CVD). The possible role of inflammatory cytokines and atherogenic markers in this process is still being elucidated. Recent research has revealed that substances like C-reactive protein (CRP), interleukin (EL)-6, and tumor necrosis factor (TNF)-alpha mirror oxidative stress and may play a role in promoting adverse vascular outcomes in both conditions. Other alterations in adipocytokines include low levels of adiponectin and increased leptin, resistin, plasminogen activator inhibitor (PAI)-1 and fibrinogen, the latter two contribute to the prothrombotic tendency. Lifestyle factors and certain medications can modify these parameters, while the phenomenal increase in the prevalence of obesity has aggravated the severity of the resultant clinical manifestations and pathophysiologic findings. Continued research looking at the role of inflammation and cytokines in the closely related conditions of metabolic syndrome and type 2 diabetes is paramount in improving our knowledge of and devising novel therapies for these disorders.
C1 Univ S Carolina, Sch Med, Div Endocrinol, Diabet Unit, Columbia, SC 29208 USA.
C3 University of South Carolina System; University of South Carolina
   Columbia
RP Rizvi, AA (corresponding author), Univ S Carolina, Sch Med, Two Med Pk,Suite 502, Columbia, SC 29203 USA.
EM arizvi@gw.mp.sc.edu
RI Rizvi, Ali/AFV-2240-2022
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NR 64
TC 16
Z9 25
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0366-6999
EI 2542-5641
J9 CHINESE MED J-PEKING
JI Chin. Med. J.
PD NOV 5
PY 2007
VL 120
IS 21
BP 1918
EP 1924
DI 10.1097/00029330-200711010-00014
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 236JD
UT WOS:000251298300014
PM 18067768
OA gold
DA 2025-06-11
ER

PT J
AU de Wit, AE
   Giltay, EJ
   de Boer, MK
   Bosker, FJ
   van der Mast, RC
   Comijs, HC
   Voshaar, RCO
   Schoevers, RA
AF de Wit, Anouk E.
   Giltay, Erik J.
   de Boer, Marrit K.
   Bosker, Fokko J.
   van der Mast, Roos C.
   Comijs, Hannie C.
   Voshaar, Richard C. Oude
   Schoevers, Robert A.
TI Associations between testosterone and metabolic syndrome in depressed
   and non-depressed older men and women
SO INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
LA English
DT Article
DE depressive disorder; major; metabolic syndrome; older adults;
   testosterone
ID HORMONE-BINDING GLOBULIN; CARDIOVASCULAR RISK-FACTORS; ANDROGENS;
   PREDICT; STRESS; HEALTH; MASS
AB Objectives Older age and major depressive disorder (MDD) are both risk factors for the development of cardiovascular diseases. Testosterone has been associated with MDD and metabolic syndrome (MetS) in men, although associations in women are less clear. Therefore, we investigated whether testosterone is associated with MetS and whether this association is different for depressed and non-depressed older men and women. Methods In this prospective cohort study, 478 participants (349 patients with MDD and 129 controls) aged between 60 and 93 years from the Netherlands Study of Depression in Older Persons were included. Total testosterone (TT) and sex-hormone binding globulin levels were measured using a second-generation radioimmune assay. Free testosterone (FT) was calculated based on TT. MetS was defined according to the National Cholesterol Education Program Adult Treatment Panel III criteria. Results A higher risk for MetS was found in men with low FT and TT (odds ratio [OR]: 0.67, 95% confidence interval [95%CI]: 0.47-0.95 and OR: 0.51, 95%CI: 0.34-0.75), and in women with high FT (OR: 1.41, 95%CI: 1.08-1.82). Strong associations in the same direction were found with adiposity, glucose, and plasma lipid MetS components at baseline, but not with changes in these components at 2-year follow-up. The associations did not significantly differ between MDD patients and controls. Conclusions Independently of having MDD, low testosterone levels in men and, in contrast, high testosterone levels in women were significantly associated with MetS and its components.
C1 [de Wit, Anouk E.; de Boer, Marrit K.; Bosker, Fokko J.; Voshaar, Richard C. Oude; Schoevers, Robert A.] Univ Groningen, Univ Med Ctr Groningen, Dept Psychiat, POB 30-001, NL-9700 RB Groningen, Netherlands.
   [Giltay, Erik J.; van der Mast, Roos C.] Leiden Univ, Dept Psychiat, Med Ctr, Leiden, Netherlands.
   [van der Mast, Roos C.] Univ Antwerp, CAPRI, Dept Psychiat, Antwerp, Belgium.
   [Comijs, Hannie C.] Vrije Univ Amsterdam Med Ctr, Amsterdam Publ Hlth Res Inst, Dept Psychiat, GGZinGeest, Amsterdam, Netherlands.
C3 University of Groningen; Leiden University - Excl LUMC; Leiden
   University; Leiden University Medical Center (LUMC); University of
   Antwerp; Vrije Universiteit Amsterdam; VU UNIVERSITY MEDICAL CENTER
RP de Wit, AE (corresponding author), Univ Groningen, Univ Med Ctr Groningen, Dept Psychiat, POB 30-001, NL-9700 RB Groningen, Netherlands.
EM a.e.de.wit@umcg.nl
RI Giltay, Erik/AAL-9948-2021
OI Schoevers, Robert A/0000-0003-0760-9866; Giltay, Erik
   J./0000-0001-8874-2292; Oude Voshaar, Richard/0000-0003-1501-4774;
   /0000-0002-9536-2148
FU NARSAD The Brain and Behaviour Research Fund [41080]; Stichting tot
   Steun VCVGZ; Fonds NutsOhra [0701-065]
FX NARSAD The Brain and Behaviour Research Fund, Grant/Award Number: 41080;
   Stichting tot Steun VCVGZ; Fonds NutsOhra, Grant/Award Number: 0701-065
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NR 49
TC 7
Z9 7
U1 0
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0885-6230
EI 1099-1166
J9 INT J GERIATR PSYCH
JI Int. J. Geriatr. Psychiatr.
PD MAR
PY 2019
VL 34
IS 3
BP 463
EP 471
DI 10.1002/gps.5040
PG 9
WC Geriatrics & Gerontology; Gerontology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Psychiatry
GA HL1CC
UT WOS:000458430400010
PM 30474223
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Veru-Lesmes, F
   Guay, S
   Shah, JL
   Schmitz, N
   Giguère, CÉ
   Joober, R
   Iyer, SN
   Malla, AK
AF Veru-Lesmes, Franz
   Guay, Stephane
   Shah, Jai L.
   Schmitz, Norbert
   Giguere, Charles-Edouard
   Joober, Ridha
   Iyer, Srividya N.
   Malla, Ashok K.
TI Adipose tissue dysregulation at the onset of psychosis: Adipokines and
   social determinants of health
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE First-episode psychosis; Psychoneuroendocrinology; Developmental origins
   of health and disease; Childhood trauma; Minority groups
ID 1ST EPISODE PSYCHOSIS; CARDIOVASCULAR-DISEASE; INSULIN-RESISTANCE;
   RISK-FACTORS; CARDIOMETABOLIC RISK; WAIST CIRCUMFERENCE; METABOLIC
   SYNDROME; SCHIZOPHRENIA; METAANALYSIS; OBESITY
AB Recent evidence suggests that patients with psychotic disorders have metabolic disturbances (e.g., insulin resistance, dyslipidemia) at the onset of the disease and before antipsychotic exposure. Such disturbances are strongly associated with adipose tissue dysregulation. Measuring adipokines, the molecular mediators of adipose function, could provide a picture of the state of metabolic regulation at the onset of psychosis. The present study explores adipokine changes in a population of first-episode psychosis (FEP) patients with minimal prior exposure to antipsychotics. The effects of social determinants of health (childhood trauma and minority status) associated with both metabolic and psychotic disorders were studied as potential determinants of this phenomenon. Data was collected through the Signature project, a biobank of clinical, socio-demographic, and biological markers. Adipokines (leptin, adiponectin, resistin and chemerin) were measured in serum of FEP patients with minimal exposure to antipsychotics (N = 48) and controls (N = 39). Data were analyzed with univariate (t-tests) and multivariate (linear regression) statistical methods.
   Patients, compared to controls, had significantly higher levels of adiponectin and resistin, and significantly lower levels of leptin and chemerin. These results persisted after controlling for sex, waist-to-height ratio, childhood trauma, and visible minority status. Adiponectin and chemerin retained their effects after further controlling for tobacco and depression. Resistin increased with childhood trauma scores; chemerin was higher in visible minority patients. Adipose tissue dysfunction is present in FEP patients, before exposure to antipsychotics. Social determinants of health contribute to adipose (and metabolic) dysregulation in FEP, but may not be the main determinants of this relationship.
C1 [Veru-Lesmes, Franz; Shah, Jai L.; Schmitz, Norbert; Joober, Ridha; Iyer, Srividya N.; Malla, Ashok K.] McGill Univ, Dept Psychiat, Montreal, PQ, Canada.
   [Veru-Lesmes, Franz; Shah, Jai L.; Schmitz, Norbert; Joober, Ridha; Iyer, Srividya N.; Malla, Ashok K.] Douglas Mental Hlth Univ Inst, 6875 LaSalle Blvd, Montreal, PQ H4H 1R3, Canada.
   [Veru-Lesmes, Franz; Shah, Jai L.; Schmitz, Norbert; Joober, Ridha; Iyer, Srividya N.; Malla, Ashok K.] Prevent & Early Intervent Program Psychosis, Montreal, PQ, Canada.
   [Guay, Stephane; Giguere, Charles-Edouard] Inst Univ Sante Mentale, Montreal, PQ, Canada.
C3 McGill University; Laval University
RP Veru-Lesmes, F (corresponding author), Douglas Mental Hlth Univ Inst, 6875 LaSalle Blvd, Montreal, PQ H4H 1R3, Canada.
EM franz.veru@mail.mcgill.ca; signature.iusmm@ssss.gouv.qc.ca
RI Guay, Stephane/AAD-6927-2022; Iyer, Srividya/AAU-2256-2021
OI Iyer, Srividya/0000-0001-5367-9086
FU Canadian Institutes of Health Research (CIHR) [68961]; Fonds de
   recherche du Quebec-Sante; Canadian Institutes of Health Research;
   National Institutes of Health Research; foundation of the Institut
   universitaire en sante mentale de Montreal; Centre integre universitaire
   de sante et de services sociaux de l'Est de l'Ile de Montreal;
   Schizophrenia Society of Canada Foundation (SSCF); Canadian College of
   Neuropsychopharmacology (CCNP)
FX The authors want to acknowledge the participants of this project who
   made it possible. The present work was supported by operating grants
   from the Canadian Institutes of Health Research (CIHR) under Grant
   #68961 (to S.N. Iyer). CIHR played no role in study design, operation of
   the project or the interpretation of the findings. Dr. S.N. Iyer has
   received funding from the Fonds de recherche du Quebec-Sante and the
   Canadian Institutes of Health Research. Dr. A.K. Malla has received
   funding from the Fonds de recherche du Quebec-Sante, National Institutes
   of Health Research and the Canadian Institutes of Health Research. Dr.
   R. Joober has received funding from the Fonds de recherche du
   Quebec-Sante and the Canadian Institutes of Health Research. Dr J. Shah
   has received funding from the Fonds de recherche du Quebec-Sante. Dr.
   Stephane Guay is the director of the Signature consortium which is
   financially supported by the foundation of the Institut universitaire en
   sante mentale de Montreal and the Centre integre universitaire de sante
   et de services sociaux de l'Est de l'Ile de Montreal. Dr. F. Veru-Lesmes
   has received a scholarship from the Fonds de recherche du Quebec-Sante
   and a doctoral studentship from the Schizophrenia Society of Canada
   Foundation (SSCF) and Canadian College of Neuropsychopharmacology
   (CCNP).
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NR 78
TC 9
Z9 11
U1 0
U2 7
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD JAN
PY 2021
VL 123
AR 104915
DI 10.1016/j.psyneuen.2020.104915
PG 9
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA PB7OT
UT WOS:000596506700018
PM 33130407
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Prasatthong, P
   Meephat, S
   Rattanakanokchai, S
   Khamseekaew, J
   Bunbupha, S
   Prachaney, P
   Maneesai, P
   Pakdeechote, P
AF Prasatthong, Patoomporn
   Meephat, Sariya
   Rattanakanokchai, Siwayu
   Khamseekaew, Juthamas
   Bunbupha, Sarawoot
   Prachaney, Parichat
   Maneesai, Putcharawipa
   Pakdeechote, Poungrat
TI Galangin Resolves Cardiometabolic Disorders through Modulation of
   AdipoR1, COX-2, and NF-κB Expression in Rats Fed a High-Fat Diet
SO ANTIOXIDANTS
LA English
DT Article
DE galangin; cardiac function; metabolic syndrome; oxidative stress;
   inflammation; adiponectin
ID OXIDATIVE STRESS; METABOLIC SYNDROME; ISCHEMIA/REPERFUSION INJURY;
   ADIPONECTIN; HYPERTENSION; INFLAMMATION; PROTECTS; GLUCOSE; OBESITY;
   CYCLOOXYGENASE
AB Galangin is a natural flavonoid. In this study, we evaluated whether galangin could alleviate signs of metabolic syndrome (MS) and cardiac abnormalities in rats receiving a high-fat (HF) diet. Male Sprague-Dawley rats were given an HF diet plus 15% fructose for four months, and they were fed with galangin (25 or 50 mg/kg), metformin (100 mg/kg), or a vehicle for the last four weeks. The MS rats exhibited signs of MS, hypertrophy of adipocytes, impaired liver function, and cardiac dysfunction and remodeling. These abnormalities were alleviated by galangin (p < 0.05). Interleukin-6 and tumor necrosis factor-alpha concentrations and expression were high in the plasma and cardiac tissue in the MS rats, and these markers were suppressed by galangin (p < 0.05). These treatments also alleviated the low levels of adiponectin and oxidative stress induced by an HF diet in rats. The downregulation of adiponectin receptor 1 (AdipoR1) and cyclooxygenase-2 (COX-2) and the upregulation of nuclear factor kappa B (NF-kappa B) expression were recovered in the galangin-treated groups. Metformin produced similar effects to galangin. In conclusion, galangin reduced cardiometabolic disorders in MS rats. These effects might be linked to the suppression of inflammation and oxidative stress and the restoration of AdipoR1, COX-2, and NF-kappa B expression.
C1 [Prasatthong, Patoomporn; Meephat, Sariya; Khamseekaew, Juthamas; Maneesai, Putcharawipa; Pakdeechote, Poungrat] Khon Kaen Univ, Dept Physiol, Fac Med, Khon Kaen 40002, Thailand.
   [Rattanakanokchai, Siwayu] Khon Kaen Univ, Fac Vet Med, Khon Kaen 40002, Thailand.
   [Bunbupha, Sarawoot] Mahasarakham Univ, Fac Med, Maha Sarakham 44000, Thailand.
   [Prachaney, Parichat] Khon Kaen Univ, Dept Anat, Fac Med, Khon Kaen 40002, Thailand.
   [Pakdeechote, Poungrat] Khon Kaen Univ, Res Inst Human High Performance & Hlth Promot, Khon Kaen 40002, Thailand.
C3 Khon Kaen University; Khon Kaen University; Mahasarakham University;
   Khon Kaen University; Khon Kaen University
RP Pakdeechote, P (corresponding author), Khon Kaen Univ, Dept Physiol, Fac Med, Khon Kaen 40002, Thailand.; Pakdeechote, P (corresponding author), Khon Kaen Univ, Res Inst Human High Performance & Hlth Promot, Khon Kaen 40002, Thailand.
EM pa_pra@kkumail.com; sariya_m@kkumail.com; siwara@kku.ac.th;
   juthakh@kku.ac.th; sarawoot.b@msu.ac.th; parpra@kku.ac.th;
   putcma@kku.ac.th; ppoung@kku.ac.th
RI Maneesai, Putcharawipa/AAK-4258-2021
FU Faculty of Medicine, the Fundamental Fund and Research Program, Khon
   Kaen University, Khon Kaen, Thailand [IN 64248]
FX This study was supported by grants from the Invitation Research Fund (IN
   64248), Faculty of Medicine, the Fundamental Fund and Research Program,
   Khon Kaen University, Khon Kaen, Thailand.
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NR 68
TC 21
Z9 21
U1 0
U2 12
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD MAY
PY 2021
VL 10
IS 5
AR 769
DI 10.3390/antiox10050769
PG 20
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA SG3RT
UT WOS:000653359700001
PM 34066039
OA gold, Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Yagi, S
   Akaike, M
   Aihara, KI
   Iwase, T
   Ishikawa, K
   Yoshida, S
   Sumitomo-Ueda, Y
   Kusunose, K
   Niki, T
   Yamaguchi, K
   Koshiba, K
   Hirata, Y
   Dagvasumberel, M
   Taketani, Y
   Tomita, N
   Yamada, H
   Soeki, T
   Wakatsuki, T
   Matsumoto, T
   Sata, M
AF Yagi, Shusuke
   Akaike, Masashi
   Aihara, Ken-ichi
   Iwase, Takashi
   Ishikawa, Kazue
   Yoshida, Sumiko
   Sumitomo-Ueda, Yuka
   Kusunose, Kenya
   Niki, Toshiyuki
   Yamaguchi, Koji
   Koshiba, Kunihiko
   Hirata, Yoichiro
   Dagvasumberel, Munkhbaatar
   Taketani, Yoshio
   Tomita, Noriko
   Yamada, Hirotsugu
   Soeki, Takeshi
   Wakatsuki, Tetsuzo
   Matsumoto, Toshio
   Sata, Masataka
TI Ezetimibe Ameliorates Metabolic Disorders and Microalbuminuria in
   Patients with Hypercholesterolemia
SO JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
LA English
DT Article
DE Metabolic syndrome; Chronic kidney disease; Oxidative stress;
   Inflammation
ID INSULIN-RESISTANCE; OXIDATIVE STRESS; STATIN THERAPY; CHOLESTEROL;
   ASSOCIATION; INHIBITION; STEATOSIS; PROTEIN; KIDNEY; LDL
AB Aim: Ezetimibe, an inhibitor of Niemann-Pick C1-like 1 protein, has been shown to reduce the intestinal absorption of cholesterol. We investigated whether it also has beneficial effects on metabolic disorder and/or renal insufficiency in patients with hypercholesterolemia.
   Methods: Ezetimibe was administered to 38 Japanese patients with hypercholesterolemia to obtain appropriate low-density lipoprotein cholesterol (LDL-chol) levels. Age-and sex-matched patients with hypercholesterolemia (n = 38) were the controls. We evaluated the effects of ezetimibe before and 4 to 8 weeks after ezetimibe treatment.
   Results: Ezetimibe significantly decreased LDL-chol levels and metabolic syndrome-related factors, including body weight, waist circumference, blood pressure; homeostasis model assessment insulin resistance (HOMA-IR), and urinary albumin excretion, were significantly reduced. In addition, it decreased the level of high-sensitivity C-reactive protein (hs-CRP), tumor necrosis factor (TNF)-alpha, the urinary excretion of 8-hydroxy-2'-deoxyguanosine, a parameter of oxidative stress, and increased the urinary excretion of nitrate and nitrite (NOx). In the controls we observed no such changes. Excepting the decrease in the serum TNF-alpha level, the effects of ezetimibe were not correlated with decreased LDL-chol levels.
   Conclusion: Ezetimibe ameliorated the status of metabolic syndrome and microalbuminuria, reduced inflammation and oxidative stress, and increased nitric oxide bioavailability in a LDL-chol reduction-dependent and -independent manner.
C1 [Yagi, Shusuke; Akaike, Masashi; Iwase, Takashi; Ishikawa, Kazue; Kusunose, Kenya; Niki, Toshiyuki; Yamaguchi, Koji; Koshiba, Kunihiko; Hirata, Yoichiro; Dagvasumberel, Munkhbaatar; Taketani, Yoshio; Tomita, Noriko; Yamada, Hirotsugu; Soeki, Takeshi; Wakatsuki, Tetsuzo; Sata, Masataka] Univ Tokushima, Dept Cardiovasc Med, Grad Sch Hlth Biosci, Tokushima 7708503, Japan.
   [Aihara, Ken-ichi; Yoshida, Sumiko; Sumitomo-Ueda, Yuka; Matsumoto, Toshio] Univ Tokushima, Dept Med & Bioregulatory Sci, Grad Sch Hlth Biosci, Tokushima 7708503, Japan.
C3 Tokushima University; Tokushima University
RP Yagi, S (corresponding author), Univ Tokushima, Dept Cardiovasc Med, Grad Sch Hlth Biosci, 3-18-15 Kuramoto Cho, Tokushima 7708503, Japan.
EM syagi@clin.med.tokushima-u.ac.jp
RI Kusunose, Kenya/AAC-9978-2021; Aihara, Ken-ichi/AEE-8245-2022; Sata,
   Masataka/IST-9041-2023
OI Kusunose, Kenya/0000-0002-4909-754X; Aihara,
   Ken-ichi/0000-0001-8906-0920; Dagvasumberel,
   Munkhbaatar/0000-0003-1810-4273; Yamada, Hirotsugu/0000-0003-3741-5560
FU Ministry of Education, Science, Sports and Culture of Japan; Ministry of
   Health, Labour and Welfare of Japan
FX This work was supported in part by Grants-in-Aid for Scientific Research
   from the Ministry of Education, Science, Sports and Culture of Japan, a
   Grant for Clinical Vascular Function and a Grant for a Study Group on
   Aseptic Femoral Neck Necrosis from the Ministry of Health, Labour and
   Welfare of Japan.
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NR 26
TC 47
Z9 47
U1 0
U2 2
PU JAPAN ATHEROSCLEROSIS SOC
PI TOKYO
PA NICHINAI-KAIKAN B1, 3-28-8 HONGO BUNKYO-KU, TOKYO, 113-0033, JAPAN
SN 1340-3478
EI 1880-3873
J9 J ATHEROSCLER THROMB
JI J. Atheroscler. Thromb.
PY 2010
VL 17
IS 2
BP 173
EP 180
DI 10.5551/jat.2378
PG 8
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 606ET
UT WOS:000278405800007
PM 20150722
OA hybrid
DA 2025-06-11
ER

PT J
AU Swiatkiewicz, I
   Wróblewski, M
   Nuszkiewicz, J
   Sutkowy, P
   Wróblewska, J
   Wozniak, A
AF Swiatkiewicz, Iwona
   Wroblewski, Marcin
   Nuszkiewicz, Jaroslaw
   Sutkowy, Pawel
   Wroblewska, Joanna
   Wozniak, Alina
TI The Role of Oxidative Stress Enhanced by Adiposity in Cardiometabolic
   Diseases
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE oxidative stress; obesity; cardiovascular disease; cardiometabolic
   diseases; coronary artery disease; metabolic syndrome; type 2 diabetes
ID OXYGEN SPECIES ROS; METABOLIC SYNDROME; RISK-FACTORS; CARDIOVASCULAR
   RISK; BLOOD-PRESSURE; LIPID-PEROXIDATION; INSULIN-RESISTANCE;
   FREE-RADICALS; ENDOTHELIAL DYSFUNCTION; ANTIOXIDANT ENZYMES
AB Cardiometabolic diseases (CMDs), including cardiovascular disease (CVD), metabolic syndrome (MetS), and type 2 diabetes (T2D), are associated with increased morbidity and mortality. The growing prevalence of CVD is mostly attributed to the aging population and common occurrence of risk factors, such as high systolic blood pressure, elevated plasma glucose, and increased body mass index, which led to a global epidemic of obesity, MetS, and T2D. Oxidant-antioxidant balance disorders largely contribute to the pathogenesis and outcomes of CMDs, such as systemic essential hypertension, coronary artery disease, stroke, and MetS. Enhanced and disturbed generation of reactive oxygen species in excess adipose tissue during obesity may lead to increased oxidative stress. Understanding the interplay between adiposity, oxidative stress, and cardiometabolic risks can have translational impacts, leading to the identification of novel effective strategies for reducing the CMDs burden. The present review article is based on extant results from basic and clinical studies and specifically addresses the various aspects associated with oxidant-antioxidant balance disorders in the course of CMDs in subjects with excess adipose tissue accumulation. We aim at giving a comprehensive overview of existing knowledge, knowledge gaps, and future perspectives for further basic and clinical research. We provide insights into both the mechanisms and clinical implications of effects related to the interplay between adiposity and oxidative stress for treating and preventing CMDs. Future basic research and clinical trials are needed to further examine the mechanisms of adiposity-enhanced oxidative stress in CMDs and the efficacy of antioxidant therapies for reducing risk and improving outcome of patients with CMDs.
C1 [Swiatkiewicz, Iwona] Nicolaus Copernicus Univ, Coll Med, Dept Cardiol & Internal Med, PL-85094 Bydgoszcz, Poland.
   [Swiatkiewicz, Iwona] Univ Calif San Diego, Div Cardiovasc Med, La Jolla, CA 92037 USA.
   [Wroblewski, Marcin; Nuszkiewicz, Jaroslaw; Sutkowy, Pawel; Wroblewska, Joanna; Wozniak, Alina] Nicolaus Copernicus Univ, Coll Med, Dept Med Biol & Biochem, PL-85092 Bydgoszcz, Poland.
C3 Nicolaus Copernicus University; University of California System;
   University of California San Diego; Nicolaus Copernicus University
RP Swiatkiewicz, I (corresponding author), Nicolaus Copernicus Univ, Coll Med, Dept Cardiol & Internal Med, PL-85094 Bydgoszcz, Poland.; Swiatkiewicz, I (corresponding author), Univ Calif San Diego, Div Cardiovasc Med, La Jolla, CA 92037 USA.
EM iwona.swiatkiewicz@gmail.com
RI Wróblewska, Joanna/G-8607-2014; Swiatkiewicz, Iwona/H-4279-2014;
   Wozniak, Alina/H-4699-2014; Nuszkiewicz, Jaroslaw/AAI-6787-2021;
   Sutkowy, Pawel/G-9282-2014; Wroblewski, Marcin/D-4710-2014
OI Wozniak, Alina/0000-0002-4492-4796; Nuszkiewicz,
   Jaroslaw/0000-0003-1378-5065; Sutkowy, Pawel/0000-0002-3479-7738;
   Wroblewska, Joanna/0000-0002-8188-8296; Wroblewski,
   Marcin/0000-0002-7887-132X
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NR 204
TC 35
Z9 36
U1 0
U2 10
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD APR
PY 2023
VL 24
IS 7
AR 6382
DI 10.3390/ijms24076382
PG 24
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA D6TY2
UT WOS:000970046000001
PM 37047352
OA gold
DA 2025-06-11
ER

PT J
AU McCullough, AJ
AF McCullough, Arthur J.
TI Epidemiology of the metabolic syndrome in the USA
SO JOURNAL OF DIGESTIVE DISEASES
LA English
DT Review
DE metabolic syndrome; epidemiology; insulin resistance; diabetes;
   nonalcoholic fatty liver disease
ID NONALCOHOLIC FATTY LIVER; CARDIOVASCULAR-DISEASE; INSULIN-RESISTANCE;
   PREVALENCE; STATEMENT; PREDICTOR; MORTALITY; FIBROSIS; OBESITY; SYSTEM
AB The metabolic syndrome is a common complex entity that has emerged as a worldwide epidemic and major public health care concern with a prevalence of approximately 25% in the United States. There have been a number of different definitions of the metabolic syndrome but all center around the metabolic abnormalities of central obesity, hypertension, decreased high-density lipoproteins and elevated triglycerides with insulin resistance as the uniting physiologic factor. The importance of the metabolic syndrome is not just related to its high prevalence rate but also because it predicts the development of diabetes and cardiovascular disease. Nonalcoholic fatty liver disease is now recognized to be the hepatic component of the metabolic syndrome, which along with its individual components - particularly diabetes and elevated triglycerides, are the major risk factors for the development of nonalcoholic steatohepatitis (NASH); the most severe form of nonalcoholic fatty liver disease. NASH may progress to cirrhosis, hepatocellular carcinoma, and liver failure. It is currently the third most common cause for liver transplantation and is projected to be the leading cause for liver transplantation in 2020. Weight loss (via diet or bariatric surgery) and vitamin E have recently been demonstrated to be effective treatments of NASH. Although these and other agents may prove to be effective treatments for NASH, the most effective therapeutic strategy would be early screening and intervention to prevent the development of insulin resistance and oxidative stress at a societal level.
C1 [McCullough, Arthur J.] Case Western Reserve Univ, Cleveland Clin, Inst Digest Dis, Dept Gastroenterol & Hepatol, Cleveland, OH 44195 USA.
   [McCullough, Arthur J.] Case Western Reserve Univ, Cleveland Clin, Lerner Coll Med, Cleveland, OH 44195 USA.
C3 University System of Ohio; Case Western Reserve University; Cleveland
   Clinic Foundation; Cleveland Clinic Foundation; University System of
   Ohio; Case Western Reserve University
RP McCullough, AJ (corresponding author), Case Western Reserve Univ, Cleveland Clin, Inst Digest Dis, Dept Gastroenterol & Hepatol, Cleveland, OH 44195 USA.
EM mcculla@ccf.org
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NR 37
TC 110
Z9 131
U1 0
U2 16
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1751-2972
EI 1751-2980
J9 J DIGEST DIS
JI J. Dig. Dis.
PD OCT
PY 2011
VL 12
IS 5
BP 333
EP 340
DI 10.1111/j.1751-2980.2010.00469.x
PG 8
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 826VL
UT WOS:000295383500004
PM 21091931
OA Bronze
DA 2025-06-11
ER

PT J
AU Ilkun, O
   Boudina, S
AF Ilkun, Olesya
   Boudina, Sihem
TI Cardiac Dysfunction and Oxidative Stress in the Metabolic Syndrome: an
   Update on Antioxidant Therapies
SO CURRENT PHARMACEUTICAL DESIGN
LA English
DT Article
DE Cardiac dysfunction; mitochondrial dysfunction; reactive oxygen species;
   antioxidants; oxidative stress; substrate utilization; metabolic
   syndrome; insulin resistance
ID MYOCARDIAL SUBSTRATE METABOLISM; HIGH-FAT DIET;
   CONGESTIVE-HEART-FAILURE; ACID-BINDING PROTEIN; CONTRACTILE DYSFUNCTION;
   INSULIN-RESISTANCE; DIABETIC CARDIOMYOPATHY; MITOCHONDRIAL DYSFUNCTION;
   ENERGY-METABOLISM; COENZYME Q(10)
AB The metabolic syndrome (MetS) is a cluster of risk factors including obesity, insulin resistance, dyslipidemia, elevated blood pressure and glucose intolerance. The MetS increases the risk for cardiovascular disease (CVD) and type 2 diabetes. Each component of the MetS causes cardiac dysfunction and their combination carries additional risk. The mechanisms underlying cardiac dysfunction in the MetS are complex and might include lipid accumulation, increased fibrosis and stiffness, altered calcium homeostasis, abnormal autophagy, altered substrate utilization, mitochondrial dysfunction and increased oxidative stress. Mitochondrial and extra-mitochondrial sources of reactive oxygen species (ROS) and reduced antioxidant defense mechanisms characterize the myocardium of humans and animals with the MetS. The mechanisms for increased cardiac oxidative stress in the MetS are not fully understood but include increased fatty acid oxidation, mitochondrial dysfunction and enhanced NADPH oxidase activity. Therapies aimed to reduce oxidative stress and enhance antioxidant defense have been employed to reduce cardiac dysfunction in the MetS in animals. In contrast, large scale clinical trials using antioxidants therapies for the treatment of CVD have been disappointing because of the lack of efficacy and undesired side effects. The focus of this review is to summarize the current knowledge about the mechanisms underlying cardiac dysfunction in the MetS with a special interest in the role of oxidative stress. Finally, we will update the reader on the results obtained with natural antioxidant and mitochondria-targeted antioxidant therapies for the treatment of CVD in the MetS.
C1 Univ Utah, Sch Med, Div Endocrinol Metab & Diabet, Salt Lake City, UT 84112 USA.
   Univ Utah, Sch Med, Program Mol Med, Salt Lake City, UT 84112 USA.
C3 Utah System of Higher Education; University of Utah; Utah System of
   Higher Education; University of Utah
RP Boudina, S (corresponding author), Div Endocrinol Metab & Diabet, Program Human Mol Biol & Genet, 15 N 2030 E Bldg 533 Rm 3410B, Salt Lake City, UT 84112 USA.
EM sihem.boudina@hmbg.utah.edu
FU American Heart Association [09SDG2220218]; National Institutes of Health
   (NIH) [P30-HL-101310]; NIH/NIDDK [T32DK091317]; American Heart
   Association (AHA) [09SDG2220218] Funding Source: American Heart
   Association (AHA)
FX This work was supported by grants 09SDG2220218 from the American Heart
   Association and P30-HL-101310 from the National Institutes of Health
   (NIH) to Sihem Boudina and Grant T32DK091317 from NIH/NIDDK to Olesya
   Ilkun. O.I. researched literature and wrote part of the manuscript. S.
   B. researched the literature, wrote part of the manuscript and
   constructed and edited the manuscript.
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NR 179
TC 105
Z9 122
U1 0
U2 32
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1381-6128
EI 1873-4286
J9 CURR PHARM DESIGN
JI Curr. Pharm. Design
PD AUG
PY 2013
VL 19
IS 27
BP 4806
EP 4817
DI 10.2174/1381612811319270003
PG 12
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 172ZA
UT WOS:000321045100003
PM 23323621
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Soriguer, F
   Rojo-Martínez, G
   Rodriguez de Fonseca, F
   García-Escobar, E
   Fuentes, EG
   Olveira, G
AF Soriguer, Federico
   Rojo-Martinez, Gemma
   Rodriguez de Fonseca, Fernando
   Garcia-Escobar, Eva
   Fuentes, Eduardo Garcia
   Olveira, Gabriel
TI Obesity and the metabolic syndrome in Mediterranean countries:: A
   hypothesis related to olive
SO MOLECULAR NUTRITION & FOOD RESEARCH
LA English
DT Review
DE adipose tissue; Mediterranean diet; metabolic syndrome; obesity; olive
   oil
ID STEAROYL-COA DESATURASE-1; HUMAN ADIPOSE-TISSUE; FATTY-ACIDS;
   DIETARY-FAT; BODY-FAT; ADIPOCYTE PRECURSORS; THRIFTY GENOTYPE;
   SKELETAL-MUSCLE; ANATOMIC SITE; GENE
AB In Mediterranean countries people would previously have consumed a diet with a high proportion of MUFA. Physical activity would have been intense with a low level of stress. The stearoyl-CoA desaturase (SCD1) system selected over thousands of years of this type of behavior must have adapted to a particular capacity of self regulation. Now, this pattern, called the "Mediterranean diet", has been broken and many people living by the Mediterranean consume a high quantity of calories, mainly from saturated or n-6-rich fats and the relative intake of MUFA has decreased. Simultaneously, physical activity has decreased and the pattern of stress has changed towards what is called a western lifestyle. In this new context, if people have a favorable, genetically conditioned SCD1 activity that will let them confront the new situation or else have some other compensatory mechanism, such as being keen on sport, etc, then they can prevent the appearance of some of the complications associated with the metabolic syndrome. If, on the other hand, the SCD1 pattern is genetically unfavorable for this new situation and they have a new cultural context, then they do not have the alternative compensatory mechanisms and the probability of developing the metabolic syndrome is high.
C1 Hosp Univ Carlos Haya, Serv Endocrinol & Nutr, Fdn Imabis, Malaga 29009, Spain.
C3 FIMABIS; Hospital Carlos Haya
RP Soriguer, F (corresponding author), Hosp Univ Carlos Haya, Serv Endocrinol & Nutr, Fdn Imabis, Malaga 29009, Spain.
EM federico.soriguer.sspa@juntadeandalucia.es
RI DE FONSECA, FERNANDO/E-9767-2012; OLVEIRA, GABRIEL/K-8778-2012;
   Rojo-Martinez, Gemma/E-3351-2010
OI OLVEIRA, GABRIEL/0000-0002-7646-2899; GARCIA-ESCOBAR,
   EVA/0000-0002-0134-3473; GARCIA-FUENTES, EDUARDO/0000-0002-3491-2724;
   Rojo-Martinez, Gemma/0000-0003-2179-2134
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NR 72
TC 34
Z9 34
U1 1
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1613-4125
EI 1613-4133
J9 MOL NUTR FOOD RES
JI Mol. Nutr. Food Res.
PD OCT
PY 2007
VL 51
IS 10
BP 1260
EP 1267
DI 10.1002/mnfr.200700021
PG 8
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA 224TW
UT WOS:000250470400008
PM 17912723
DA 2025-06-11
ER

PT J
AU Kalenderoglu, A
   Savas, HA
   Gergerlioglu, HS
   Basarali, K
   Yumru, M
   Selek, S
   Büyükbas, S
   Ergene, N
AF Kalenderoglu, Aysun
   Savas, Haluk A.
   Gergerlioglu, H. Serdar
   Basarali, Kemal
   Yumru, Mehmet
   Selek, Salih
   Buyukbas, Sadik
   Ergene, Neyhan
TI Correlation Between Metabolic Syndrome and Serum Ghrelin Levels in
   Bipolar Patients
SO NOROPSIKIYATRI ARSIVI-ARCHIVES OF NEUROPSYCHIATRY
LA English
DT Article
DE Bipolar disorder; metabolic syndrome; ghrelin
ID GROWTH-HORMONE SECRETION; CORONARY-HEART-DISEASE; WEIGHT-GAIN;
   INSULIN-SECRETION; GH SECRETION; FOOD-INTAKE; PREVALENCE; OBESITY;
   ANTIPSYCHOTICS; SCHIZOPHRENIA
AB Objective: The aim of this study is to investigate whether serum ghrelin levels are associated with metabolic syndrome (MetS) in bipolar patients.
   Methods: A total of 60 bipolar disorder patients and 30 healthy volunteers were included in the study. The patient group was separated into two subgroups according to the use of atypical antipsychotics (AA)-risperidone, quetiapine, olanzapine or mood stabilizers (MS)-lithium, valproic acid, carbamazepine, lamotrigine. The serum ghrelin level was measured by human ghrelin ELISA kits. Patients were diagnosed with MetS according to the National Cholesterol Education Program Adult Treatment Panel 3 (NCEP ATP 3) criteria; MetS was considered present when 3 or more criteria were met.
   Results: Among bipolar patients included in the study, 51.7% (n=31) were treated only with AA, while 48.8% (n=29) were treated with MS alone. MetS diagnosis was established in 36.7% (n=22) of patients. There was no significant difference in ghrelin levels when comparing patients with and without MetS. Additionally, there were no significant differences among the patients with MetS using AAs and among the patients with MetS using MSs in terms of ghrelin levels. The serum ghrelin levels were found to be significantly lower in bipolar patients compared to controls. Negative correlation was detected between ghrelin and fasting blood glucose.
   Conclusion: The decrease in antioxidant enzyme SOD after ECT may damage the neurons by increasing oxidative stress. Thus, possible benefits of antioxidant supplementation during ECT should be investigated. Additionally, higher pre-ECT oxidant levels may predict a poor response to ECT in depression. (Archives of Neuropsychiatry 2010; 47: 328-32)
C1 [Kalenderoglu, Aysun] Kahta Devlet Hastanesi, Psikiyatri Bolumu, Adiyaman, Turkey.
   [Savas, Haluk A.] Gaziantep Univ, Tip Fak, Psikiyatri Bilim Dali, Gaziantep, Turkey.
   [Gergerlioglu, H. Serdar; Ergene, Neyhan] Selcuk Univ, Tip Fak, Fizyol Bolumu, Konya, Turkey.
   [Basarali, Kemal; Buyukbas, Sadik] Selcuk Univ, Tip Fak, Biyokimya Bolumu, Konya, Turkey.
   [Yumru, Mehmet] Terapi Tip Merkezi, Psikiyatri Bolumu, Antalya, Turkey.
   [Selek, Salih] Harran Univ, Tip Fak, Psikiyatri Bolumu, Sanliurfa, Turkey.
C3 Kahta State Hospital; Gaziantep University; Selcuk University; Selcuk
   University; Harran University
RP Kalenderoglu, A (corresponding author), Kahta Devlet Hastanesi, Psikiyatri Bolumu, Adiyaman, Turkey.
EM ilhan_aysun@yahoo.com
RI Selek, Salih/B-4939-2009; Yumru, Mehmet/AAW-9132-2020; gergerlioglu,
   hasan serdar/AAG-8348-2021
OI Selek, Salih/0000-0001-5197-5682; gergerlioglu, hasan
   serdar/0000-0002-8836-0726; Yumru, Mehmet/0000-0002-2117-7775
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NR 44
TC 4
Z9 4
U1 0
U2 31
PU AVES
PI SISLI
PA BUYUKDERE CAD 105-9, MECIDIYEKOY, SISLI, ISTANBUL 34394, TURKEY
SN 1300-0667
EI 1309-4866
J9 NOROPSIKIYATRI ARS
JI Noropsikiyatri Ars.
PY 2010
VL 47
IS 4
BP 328
EP 332
DI 10.4274/npa.y5648
PG 5
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 702GV
UT WOS:000285883500012
DA 2025-06-11
ER

PT J
AU Ebrahimian, Z
   Razavi, BM
   Shaegh, SAM
   Hosseinzadeh, H
AF Ebrahimian, Zeinab
   Razavi, Bibi Marjan
   Shaegh, Seyed Ali Mousavi
   Hosseinzadeh, Hossein
TI Effects of Portulaca oleracea L. (purslane) on the metabolic
   syndrome: A review
SO IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
LA English
DT Review
DE Diabetes mellitus; Hypertension Metabolic syndrome; Obesity Portulaca
   oleracea; Purslane
ID AQUEOUS EXTRACT; OXIDATIVE STRESS; ANTIDIABETIC ACTIVITY;
   DIABETIC-NEPHROPATHY; MEDICINAL-PLANTS; POLYSACCHARIDE; CONSTITUENT;
   SAFFRON; SEEDS; PHARMACOLOGY
AB Metabolic syndrome (MetS) is defined as a disorder with multiple abnormalities, including obesity, high blood pressure, dyslipidemia, and high blood glucose. MetS is the best-known risk factor for type 2 diabetes mellitus (T2DM), cardiovascular disease (CVD), and obesity. With the globally increasing prevalence of MetS and its related abnormalities, attention to safe and effective prevention and treatment of this complex disorder has been increased. In particular, most treatments have been devoted to using natural agents that could provide more reliable and effective medicinal products with fewer side effects. Portulaca oleracea L. (purslane) is an herb whose therapeutic properties could be found in some ancient medical books. Purslane has shown analgesic, antispasmodic, skeletal muscle relaxant, bronchodilator, antiasthmatic, anti-inflammatory, antiseptic, diuretic, antibacterial, antipyretic, and wound-healing properties. In addition, purslane's hypoglycemic and hypolipidemic properties have been reported in different studies. The positive effects of this plant include reducing stress oxidative and inflammation along with the atherogenic index, improving insulin level and glucose uptake, decreasing lipid profiles, and ameliorating weight gain. These activities could reduce MetS complications. This review aims to provide a comprehensive overview of various in vitro, animal, and human studies regarding the effect of Portulaca oleracea on metabolic syndrome to better understand the underlying mechanisms of action for designing more effective treatments.
C1 [Ebrahimian, Zeinab; Razavi, Bibi Marjan; Hosseinzadeh, Hossein] Mashhad Univ Med Sci, Sch Pharm, Dept Pharmacodynam & Toxicol, Mashhad, Razavi Khorasan, Iran.
   [Razavi, Bibi Marjan] Mashhad Univ Med Sci, Targeted Drug Delivery Res Ctr, Sch Pharm, Dept Pharmacodynam & Toxicol, Mashhad, Razavi Khorasan, Iran.
   [Shaegh, Seyed Ali Mousavi] Mashhad Univ Med Sci, Ghaem Hosp, Clin Res Unit, Mashhad, Razavi Khorasan, Iran.
   [Shaegh, Seyed Ali Mousavi] Mashhad Univ Med Sci, Orthoped Res Ctr, Mashhad, Razavi Khorasan, Iran.
   [Shaegh, Seyed Ali Mousavi] Mashhad Univ Med Sci, Bu Ali Res Inst, Lab Microfluid & Med Microsyst, Mashhad, Razavi Khorasan, Iran.
   [Hosseinzadeh, Hossein] Mashhad Univ Med Sci, Pharmaceut Res Ctr, Pharmaceut Technol Inst, Mashhad, Razavi Khorasan, Iran.
C3 Mashhad University of Medical Sciences; Mashhad University of Medical
   Sciences; Mashhad University of Medical Sciences; Mashhad University of
   Medical Sciences; Mashhad University of Medical Sciences; Mashhad
   University of Medical Sciences
RP Hosseinzadeh, H (corresponding author), Mashhad Univ Med Sci, Sch Pharm, Dept Pharmacodynam & Toxicol, Mashhad, Razavi Khorasan, Iran.; Hosseinzadeh, H (corresponding author), Mashhad Univ Med Sci, Pharmaceut Res Ctr, Pharmaceut Technol Inst, Mashhad, Razavi Khorasan, Iran.
EM hosseinzadehh@mums.ac.ir
RI Razavi, Bibi/AAY-5636-2020; Hosseinzadeh, Hossein/F-3013-2010
FU Mashhad University of Medical Sciences, Iran
FX We thank the Vice-Chancellor of Research, Mashhad University of Medical
   Sciences, Iran for financial support.
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NR 112
TC 9
Z9 9
U1 2
U2 6
PU MASHHAD UNIV MED SCIENCES
PI MASHHAD
PA VICE-CHANCELLOR FOR RES CTR OFF IJBMS, DANESHGAH ST, PO BOX 9138813944 -
   445, MASHHAD, 00000, IRAN
SN 2008-3866
EI 2008-3874
J9 IRAN J BASIC MED SCI
JI Iran. J. Basic Med. Sci.
PD NOV
PY 2022
VL 25
IS 11
BP 1275
EP 1285
DI 10.22038/IJBMS.2022.63264.13967
PG 11
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA 8M2BT
UT WOS:000924277300001
PM 36474567
DA 2025-06-11
ER

PT J
AU Johnson, R
   de Beer, D
   Dludla, PV
   Ferreira, D
   Muller, CJF
   Joubert, E
AF Johnson, Rabia
   de Beer, Dalene
   Dludla, Phiwayinkosi V.
   Ferreira, Daneel
   Muller, Christo J. F.
   Joubert, Elizabeth
TI Aspalathin from Rooibos ( Aspalathus linearis ): A Bioactive
   C -glucosyl Dihydrochalcone with Potential to Target the
   Metabolic Syndrome
SO PLANTA MEDICA
LA English
DT Article
DE Aspalathus linearis; Fabaceae; aspalathin; metabolic syndrome; oxidative
   stress; molecular mechanism; bioavailability; herb-drug interactions
ID HUMAN INTESTINAL BACTERIUM; FATTY-ACID-METABOLISM; INSULIN-RESISTANCE;
   OXIDATIVE STRESS; IN-VITRO; ANTIOXIDANT ACTIVITY; TNF-ALPHA;
   PHENOLIC-COMPOUNDS; AQUEOUS EXTRACTS; NATURAL-PRODUCTS
AB Aspalathin is a C -glucosyl dihydrochalcone that is abundantly present in Aspalathus linearis . This endemic South African plant, belonging to the Cape Floristic region, is normally used for production of rooibos, a herbal tea. Aspalathin was valued initially only as precursor in the formation of the characteristic red-brown colour of fermented rooibos, but the hype about the potential role of natural antioxidants to alleviate oxidative stress, shifted interest in aspalathin to its antioxidant properties and subsequently, its potential role to improve metabolic syndrome, a disease condition interrelated with oxidative stress. The potential use of aspalathin or aspalathin-rich rooibos extracts as a condition-specific nutraceutical is hampered by the limited supply of green rooibos (i.e., unfermented plant material) and low levels in fermented rooibos, providing incentive for its synthesis. In vitro and in vivo studies relating to the metabolic activity of aspalathin are discussed and cellular mechanisms by which aspalathin improves glucose and lipid metabolism are proposed. Other aspects covered in this review, which are relevant in view of the potential use of aspalathin as an adjunctive therapy, include its poor stability and bioavailability, as well as potential adverse herb-drug interactions, in particular interference with the metabolism of certain commonly prescribed chronic medications for hyperglycaemia and dyslipidaemia.
C1 [Johnson, Rabia; Dludla, Phiwayinkosi V.; Muller, Christo J. F.] Med Res Council MRC, Biomed Res & Innovat Platform BRIP, Tygerberg, South Africa.
   [Johnson, Rabia; Dludla, Phiwayinkosi V.; Muller, Christo J. F.] Stellenbosch Univ, Fac Hlth Sci, Div Med Physiol, Tygerberg, South Africa.
   [de Beer, Dalene; Joubert, Elizabeth] Infruitec Nietvoorbij, Agr Res Council ARC, Plant Bioact Grp, Postharvest & Agroproc Technol, Private Bag X5026, ZA-7599 Stellenbosch, South Africa.
   [de Beer, Dalene; Joubert, Elizabeth] Stellenbosch Univ, Dept Food Sci, Stellenbosch, South Africa.
   [Ferreira, Daneel] Univ Mississippi, Dept BioMol Sci, Div Pharmacognosy, Oxford, MS USA.
   [Ferreira, Daneel] Univ Mississippi, Sch Pharm, Res Inst Pharmaceut Sci, Oxford, MS USA.
   [Muller, Christo J. F.] Univ Zululand, Dept Biochem & Microbiol, Kwa Dlangezwa, South Africa.
C3 Stellenbosch University; Agricultural Research Council of South Africa;
   Stellenbosch University; University of Mississippi; University of
   Mississippi; University of Zululand
RP Joubert, E (corresponding author), Infruitec Nietvoorbij, Agr Res Council ARC, Plant Bioact Grp, Postharvest & Agroproc Technol, Private Bag X5026, ZA-7599 Stellenbosch, South Africa.
EM JoubertL@arc.agric.za
RI De Beer, Dalene/E-8831-2010; Johnson, Rabia/ADW-4478-2022
OI Dludla, Phiwayinkosi/0000-0001-5965-3610; Johnson,
   Rabia/0000-0002-6328-0789; Joubert, Elizabeth/0000-0002-9717-9769; De
   Beer, Dalene/0000-0002-3680-142X
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NR 167
TC 62
Z9 64
U1 0
U2 22
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0032-0943
EI 1439-0221
J9 PLANTA MED
JI Planta Med.
PD JUL
PY 2018
VL 84
IS 9-10
DI 10.1055/s-0044-100622
PG 20
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA GJ9JA
UT WOS:000435715600003
PM 29388183
OA Bronze
DA 2025-06-11
ER

PT J
AU Chi, MH
   Chang, HH
   Tzeng, NS
   Huang, SY
   Chou, KR
   Tsai, HC
   Yang, YK
   Lu, RB
   Chen, PS
AF Chi, Mei Hung
   Chang, Hui Hua
   Tzeng, Nian-Sheng
   Huang, San-Yuan
   Chou, Kuei-Ru
   Tsai, Hsin Chun
   Yang, Yen Kuang
   Lu, Ru-Band
   Chen, Po See
TI The prevalence of metabolic syndrome in drug-naive bipolar II disorder
   patients before and after twelve week pharmacological intervention
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Bipolar disorder; Body mass index; Metabolic syndrome
ID SERUM LEPTIN LEVELS; WEIGHT-GAIN; OBESITY; DEPRESSION; VALPROATE;
   ABNORMALITIES; COMORBIDITY; LITHIUM; SPECT
AB Background: Accumulating evidence indicates a high prevalence rate of metabolic disturbance in bipolar disorder (BP) patients. However, the prevalence across BP subtypes has been investigated to a lesser degree. In the current study, we surveyed the prevalence of metabolic syndrome among drug-naive bipolar II patients. Moreover, the effects of pharmacological treatment on metabolic indexes were also evaluated.
   Methods: This study recruited fifty-six drug-naive BP II patients diagnosed according to the DSM-IV criteria. Among them, forty-four patients completed a 12-week pharmacological intervention with valproic acid, fluoxetine and lorazepam. Metabolic profiles and body mass index (BMI) were measured at baseline and 2 weeks, 8 weeks, and 12 weeks after receiving medication.
   Results: The mean age of the 56 patients was 30.3 +/- 11.1. Before receiving medication, 6.5% of the patients met the ATP III criterion for metabolic syndrome. Among the 44 patients who completed the 12-week pharmacological intervention, the prevalence of metabolic syndrome increased from 7% to 10%. Repeated measurements showed that the changes in metabolic indexes were not significant, with the exceptions of BMI, waist circumference, and buttock circumference. In addition, the interaction between the improvement of hypomanic symptoms and BMI change was significant.
   Limitations: The study was limited by the follow-up duration and sample size.
   Conclusions: In drug-naive BP II patients, the prevalence of metabolic syndrome was significantly lower than that observed before in BP I patients. However, medications use was also associated with an increased risk of metabolic disturbance, although the impact was lesser. Clinical evidence suggests that metabolism and emotion homeostasis might share common mechanisms. (C) 2013 Elsevier B.V. All rights reserved.
C1 [Chi, Mei Hung; Tsai, Hsin Chun; Yang, Yen Kuang; Lu, Ru-Band; Chen, Po See] Natl Cheng Kung Univ, Dept Psychiat, Coll Med, Natl Cheng Kung Univ Hosp, Tainan 70428, Taiwan.
   [Chi, Mei Hung; Tsai, Hsin Chun; Chen, Po See] Natl Cheng Kung Univ, Dept Psychiat, Dou Liou Branch, Yunlin, Taiwan.
   [Chang, Hui Hua] Natl Cheng Kung Univ, Inst Biopharmaceut Sci, Coll Med, Tainan 70428, Taiwan.
   [Tzeng, Nian-Sheng; Huang, San-Yuan] Triserv Gen Hosp, Natl Def Med Ctr, Dept Psychiat, Taipei, Taiwan.
   [Chou, Kuei-Ru] Taipei Med Univ, Grad Inst Nursing, Coll Nursing, Taipei, Taiwan.
   [Yang, Yen Kuang; Lu, Ru-Band; Chen, Po See] Natl Cheng Kung Univ, Addict Res Ctr, Tainan 70428, Taiwan.
C3 National Cheng Kung University; National Cheng Kung University Hospital;
   National Cheng Kung University; National Cheng Kung University; National
   Defense Medical Center; Tri-Service General Hospital; Taipei Medical
   University; National Cheng Kung University
RP Chen, PS (corresponding author), Natl Cheng Kung Univ, Dept Psychiat, Coll Med, 138 Sheng Li Rd, Tainan 70428, Taiwan.
EM chenps@mail.ncku.edu.tw
RI Chang, Hui/AGD-4270-2022; Tzeng, Nian-Sheng/AAU-4945-2021; Chen,
   Po/AAA-6492-2021; Chen, Han-Shen/E-5881-2018
OI Chang, Hui Hua/0000-0001-7866-5481; chou, kueiru/0000-0002-4882-3503
FU National Science Council of Taiwan [NSC 100-2627-B-006-012]
FX The authors would like to thank the National Science Council of Taiwan
   (NSC 100-2627-B-006-012) for the financial support.
CR Atmaca M, 2002, NEUROPSYCHOBIOLOGY, V46, P67, DOI 10.1159/000065414
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NR 37
TC 10
Z9 11
U1 0
U2 8
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD MAR 20
PY 2013
VL 146
IS 1
BP 79
EP 83
DI 10.1016/j.jad.2012.08.042
PG 5
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA 098WE
UT WOS:000315579000010
PM 23017540
DA 2025-06-11
ER

PT J
AU Mazloomi, SM
   Samadi, M
   Davarpanah, H
   Babajafari, S
   Clark, CCT
   Ghaemfar, Z
   Rezaiyan, M
   Mosallanezhad, A
   Shafiee, M
   Rostami, H
AF Mazloomi, Seyed Mohammad
   Samadi, Mohammad
   Davarpanah, Hajar
   Babajafari, Siavash
   Clark, Cain C. T.
   Ghaemfar, Zohreh
   Rezaiyan, Mojtaba
   Mosallanezhad, Abdolhamid
   Shafiee, Maryam
   Rostami, Hosein
TI The effect of Spirulina sauce, as a functional food, on
   cardiometabolic risk factors, oxidative stress biomarkers, glycemic
   profile, and liver enzymes in nonalcoholic fatty liver disease patients:
   A randomized double-blinded clinical trial
SO FOOD SCIENCE & NUTRITION
LA English
DT Article
DE fatty liver grade; glycemic profile; inflammation; nonalcoholic fatty
   liver disease; Spirulina
ID C-PHYCOCYANIN; ANTIOXIDANT PROPERTIES; ARTHROSPIRA-MAXIMA; HEPATIC
   STEATOSIS; PLATENSIS; STEATOHEPATITIS; SUPPLEMENTATION; DIET;
   INFLAMMATION; AGGREGATION
AB Objective: This study sought to investigate the effect of Spirulina on cardiometabolic risk factors, oxidative stress biomarkers, glycemic profile, and liver enzymes in nonalcoholic fatty liver disease (NAFLD) patients.
   Methods: This randomized, double-blind clinical trial was performed on 46 NAFLD patients. Subjects were allocated to consume either Spirulina sauce or placebo, each 20 g/day for 8 weeks. Fatty liver grade, liver enzymes, anthropometric parameters, blood pressure, and serum lipids, glucose, insulin, malondialdehyde, and antioxidant capacity were assessed pre- and postintervention.
   Results: Fatty liver grade was significantly different between the two groups. A significant change for ALT (alanine aminotransferase) and AST (aspartate aminotransferase) was seen between the two groups (p = .03 and .02, respectively), while ALP (alkaline phosphatase) serum levels were not significantly different within or between groups. Pertaining to glycemic profile, all variables, except HOMA-IR, were not significantly different within or between groups. Finally, statistically significant changes were seen in both MDA (malondialdehyde) and TAC (total antioxidant capacity) among the groups (p = .04 and <.001, respectively).
   Conclusions: Spirulina may improve fatty liver grade by modifying liver enzymes, oxidative stress, and some lipid profiles; however, there was effect of Spirulina on anthropometric characteristics and blood pressure.
C1 [Mazloomi, Seyed Mohammad; Davarpanah, Hajar; Mosallanezhad, Abdolhamid] Shiraz Univ Med Sci, Sch Nutr & Food Sci, Dept Food Hyg & Qual Control, Nutr Res Ctr, Shiraz, Iran.
   [Samadi, Mohammad] Baqiyatallah Univ Med Sci, Exercise Physiol Res Ctr, Tehran, Iran.
   [Babajafari, Siavash; Ghaemfar, Zohreh; Rezaiyan, Mojtaba] Shiraz Univ Med Sci, Sch Food & Nutr Sci, Dept Clin Nutr, Nutr Res Ctr, Shiraz, Iran.
   [Clark, Cain C. T.] Coventry Univ, Ctr Intelligent Healthcare, Coventry, W Midlands, England.
   [Shafiee, Maryam] Shiraz Univ Med Sci, Nephrourol Res Ctr, Shiraz, Iran.
   [Rostami, Hosein] Baqiyatallah Univ Med Sci, Hlth Res Ctr, Tehran, Iran.
C3 Shiraz University of Medical Science; Baqiyatallah University of Medical
   Sciences (BMSU); Shiraz University of Medical Science; Coventry
   University; Shiraz University of Medical Science; Baqiyatallah
   University of Medical Sciences (BMSU)
RP Rostami, H (corresponding author), Baqiyatallah Univ Med Sci, Hlth Res Ctr, Tehran, Iran.
EM hosein_rostami59@yahoo.com
RI Esfandabad, Siavash/A-6807-2019; Mazloomi, Seyed/K-1625-2013; shafiee,
   maryam/KVB-8618-2024; Clark, Cain/I-4480-2019; Samadi,
   Mohammad/A-6574-2019
OI Clark, Dr. Cain/0000-0002-6610-4617
FU Baqiyatallah University of Medical Sciences [98000190]
FX Baqiyatallah University of Medical Sciences, Grant/Award Number:
   98000190
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NR 51
TC 23
Z9 24
U1 0
U2 9
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2048-7177
J9 FOOD SCI NUTR
JI Food Sci. Nutr.
PD FEB
PY 2022
VL 10
IS 2
BP 317
EP 328
DI 10.1002/fsn3.2368
EA JUN 2021
PG 12
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA YV6PY
UT WOS:000660328500001
PM 35154670
OA Green Published
DA 2025-06-11
ER

PT J
AU Marchetti, E
   Monaco, A
   Procaccini, L
   Mummolo, S
   Gatto, R
   Tetè, S
   Baldini, A
   Tecco, S
   Marzo, G
AF Marchetti, Enrico
   Monaco, Annalisa
   Procaccini, Laura
   Mummolo, Stefano
   Gatto, Roberto
   Tete, Stefano
   Baldini, Alberto
   Tecco, Simona
   Marzo, Giuseppe
TI Periodontal disease: the influence of metabolic syndrome
SO NUTRITION & METABOLISM
LA English
DT Review
DE Oxidative stress; Metabolic syndrome; Adipocytokines; Periodontitis
ID GLYCATION END-PRODUCTS; NECROSIS-FACTOR-ALPHA; PORPHYROMONAS-GINGIVALIS
   LIPOPOLYSACCHARIDE; TOTAL ANTIOXIDANT CAPACITY; TYPE-2 DIABETES
   PATIENTS; OXIDATIVE STRESS; INSULIN-RESISTANCE; PHYSICAL-ACTIVITY; HEME
   OXYGENASE-1; MICROMOLAR CONCENTRATIONS
AB Metabolic syndrome (MetS) is a cluster of cardiovascular risk factors that include obesity, impaired glucose tolerance or diabetes, hyperinsulinemia, hypertension, and dyslipidemia. Recently, more attention has been reserved to the correlation between periodontitis and systemic health. MetS is characterized by oxidative stress, a condition in which the equilibrium between the production and the inactivation of reactive oxygen species (ROS) becomes disrupted. ROS have an essential role in a variety of physiological systems, but under a condition of oxidative stress, they contribute to cellular dysfunction and damage. Oxidative stress may act as a common link to explain the relationship between each component of MetS and periodontitis. All those conditions show increased serum levels of products derived from oxidative damage, promoting a proinflammatory state. Moreover, adipocytokines, produced by the fat cells of fat tissue, might modulate the balance between oxidant and antioxidant activities. An increased caloric intake involves a higher metabolic activity, which results in an increased production of ROS, inducing insulin resistance. At the same time, obese patients require more insulin to maintain blood glucose homeostasis - a state known as hyperinsulinemia, a condition that can evolve into type 2 diabetes. Oxidation products can increase neutrophil adhesion and chemotaxis, thus favoring oxidative damage. Hyperglycemia and an oxidizing state promote the genesis of advanced glycation end-products, which could also be implicated in the degeneration and damage of periodontal tissue. Thus, MetS, the whole of interconnected factors, presents systemic and local manifestations, such as cardiovascular disease and periodontitis, related by a common factor known as oxidative stress.
C1 [Marchetti, Enrico; Monaco, Annalisa; Procaccini, Laura; Mummolo, Stefano; Gatto, Roberto; Tecco, Simona; Marzo, Giuseppe] Univ Aquila, Dept Life Hlth & Environm Sci, I-67100 Laquila, Italy.
   [Tete, Stefano] Univ G dAnnunzio, Dept Oral Sci Nano & Biotechnol, Chieti, Italy.
   [Baldini, Alberto] Univ Roma Tor Vergata, Dept Oral Sci, Rome, Italy.
C3 University of L'Aquila; G d'Annunzio University of Chieti-Pescara;
   University of Rome Tor Vergata
RP Tecco, S (corresponding author), Univ Aquila, Dept Life Hlth & Environm Sci, I-67100 Laquila, Italy.
EM simtecc@unich.it
RI MARCHETTI, ENRICO/AAG-7883-2019; Tecco, Simona/AAZ-2264-2020
OI Monaco, Annalisa/0000-0002-9567-4459; MARCHETTI,
   ENRICO/0000-0001-6461-7876; mummolo, stefano/0000-0002-3566-0434; MARZO,
   Giuseppe/0000-0001-9088-7749; Gatto, Roberto/0000-0002-1965-6080
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NR 121
TC 89
Z9 101
U1 2
U2 34
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1743-7075
J9 NUTR METAB
JI Nutr. Metab.
PD SEP 25
PY 2012
VL 9
AR 88
DI 10.1186/1743-7075-9-88
PG 13
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 041XD
UT WOS:000311434200001
PM 23009606
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Moore, BF
   Clark, ML
   Bachand, A
   Reynolds, SJ
   Nelson, TL
   Peel, JL
AF Moore, Brianna F.
   Clark, Maggie L.
   Bachand, Annette
   Reynolds, Stephen J.
   Nelson, Tracy L.
   Peel, Jennifer L.
TI Interactions Between Diet and Exposure to Secondhand Smoke on Metabolic
   Syndrome Among Children: NHANES 2007-2010
SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Article
ID NUTRITION-EXAMINATION-SURVEY; CORONARY-HEART-DISEASE; OXIDATIVE STRESS;
   CHILDHOOD OBESITY; EDUCATION-PROGRAM; MATERNAL SMOKING; NATIONAL-HEALTH;
   VITAMIN-E; ADOLESCENTS; RISK
AB Context: Metabolic syndrome is likely influenced by a complex interaction between exposure to secondhand smoke (SHS) and diet, but no studies have evaluated this relationship.
   Objective: This study aimed to investigate the interaction between diet and exposure to SHS on metabolic syndrome among 12-19 year olds.
   Design and Participants: We used weighted logistic regression, adjusting for potential confounders, to examine interaction of these risk factors on the prevalence of metabolic syndrome among 12-19 year olds participating in the National Health and Nutrition Examination Survey (2007-2010). Interaction was assessed by introducing product terms between SHS (4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol, cotinine, and self-report) and the individual nutrients (dietary fiber, eicosapentaenoic acid, docosahexaenoic acid, vitamin C, and vitamin E) and nutrient patterns in separate models; the relative excess risk due to interaction was used to evaluate interaction on the additive scale.
   Results: The joint effect between high exposure to SHS and low levels of certain nutrients (vitamin E and omega-3 polyunsaturated fatty acids) on metabolic syndrome risk was greater than would be expected from the effects of the individual exposures alone (for example, relative excess risk due to interaction for SHS and vitamin E = 7.5; 95% confidence interval, 2.5-17.8).
   Conclusions: Prevention strategies for metabolic syndrome aimed at reducing SHS exposures and improving diet quality may exceed the expected benefits based on targeting these risk factors separately.
C1 [Moore, Brianna F.; Clark, Maggie L.; Bachand, Annette; Reynolds, Stephen J.; Peel, Jennifer L.] Colorado State Univ, Dept Environm & Radiol Hlth Sci, Ft Collins, CO 80523 USA.
   [Nelson, Tracy L.] Colorado State Univ, Dept Hlth & Exercise Sci, Ft Collins, CO 80523 USA.
C3 Colorado State University System; Colorado State University Fort
   Collins; Colorado State University System; Colorado State University
   Fort Collins
RP Moore, BF (corresponding author), Colorado State Univ, 1681 Campus Delivery, Ft Collins, CO 80526 USA.
EM Brianna.Moore@colostate.edu
RI Nelson, Tracy/ACF-1636-2022; Moore, Brianna/AAZ-1342-2020
OI Moore, Brianna/0000-0002-1084-3349; Clark, Maggie/0000-0002-8613-5736
FU American Heart Association [14PRE18230007]; American Heart Association
   (AHA) [14PRE18230007] Funding Source: American Heart Association (AHA)
FX This project was supported by the American Heart Association (fund
   number 14PRE18230007).
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NR 40
TC 28
Z9 27
U1 1
U2 14
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0021-972X
EI 1945-7197
J9 J CLIN ENDOCR METAB
JI J. Clin. Endocrinol. Metab.
PD JAN
PY 2016
VL 101
IS 1
BP 51
EP 57
DI 10.1210/jc.2015-2477
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA DN6UT
UT WOS:000377212700010
PM 26495750
OA Bronze
DA 2025-06-11
ER

PT J
AU Forni, C
   Facchiano, F
   Bartoli, M
   Pieretti, S
   Facchiano, A
   D'Arcangelo, D
   Norelli, S
   Valle, G
   Nisini, R
   Beninati, S
   Tabolacci, C
   Jadeja, RN
AF Forni, Cinzia
   Facchiano, Francesco
   Bartoli, Manuela
   Pieretti, Stefano
   Facchiano, Antonio
   D'Arcangelo, Daniela
   Norelli, Sandro
   Valle, Giorgia
   Nisini, Roberto
   Beninati, Simone
   Tabolacci, Claudio
   Jadeja, Ravirajsinh N.
TI Beneficial Role of Phytochemicals on Oxidative Stress and Age-Related
   Diseases
SO BIOMED RESEARCH INTERNATIONAL
LA English
DT Review
ID METABOLIC SYNDROME; QUERCETIN
AB Aging is related to a number of functional and morphological changes leading to progressive decline of the biological functions of an organism. Reactive Oxygen Species (ROS), released by several endogenous and exogenous processes, may cause important oxidative damage to DNA, proteins, and lipids, leading to important cellular dysfunctions. The imbalance between ROS production and antioxidant defenses brings to oxidative stress conditions and, related to accumulation of ROS, aging-associated diseases. The purpose of this review is to provide an overview of the most relevant data reported in literature on the natural compounds, mainly phytochemicals, with antioxidant activity and their potential protective effects on age-related diseases such as metabolic syndrome, diabetes, cardiovascular disease, cancer, neurodegenerative disease, and chronic inflammation, and possibly lower side effects, when compared to other drugs.
C1 [Forni, Cinzia; Valle, Giorgia; Beninati, Simone] Univ Roma Tor Vergata, Dept Biol, Rome, Italy.
   [Facchiano, Francesco] Ist Super Sanita, Dept Oncol & Mol Med, Rome, Italy.
   [Bartoli, Manuela] Augusta Univ, Med Coll Georgia, Dept Ophthalmol, Augusta, GA USA.
   [Pieretti, Stefano] Ist Super Sanita, Natl Ctr Drug Res & Evaluat, Rome, Italy.
   [Facchiano, Antonio; D'Arcangelo, Daniela] IDI IRCCS, Ist Dermopat Immacolata, Lab Mol Oncol, Rome, Italy.
   [Norelli, Sandro; Nisini, Roberto] Ist Super Sanita, Dept Infect Dis, Rome, Italy.
   [Tabolacci, Claudio] Univ Campus Biomed, Dept Med, Rome, Italy.
   [Jadeja, Ravirajsinh N.] Augusta Univ, Med Coll Georgia, Dept Biochem & Mol Biol, Augusta, GA USA.
C3 University of Rome Tor Vergata; Istituto Superiore di Sanita (ISS);
   University System of Georgia; Augusta University; Istituto Superiore di
   Sanita (ISS); IRCCS Istituto Dermopatico dell'Immacolata (IDI); Istituto
   Superiore di Sanita (ISS); University Campus Bio-Medico - Rome Italy;
   University System of Georgia; Augusta University
RP Tabolacci, C (corresponding author), Univ Campus Biomed, Dept Med, Rome, Italy.
EM claudiotabolacci@tiscali.it
RI Tabolacci, Claudio/U-4194-2017; Facchiano, Francesco/K-8716-2016;
   Beninati, Simone/AAE-7685-2020; Jadeja, Ravirajsinh/G-3116-2011; Nisini,
   Roberto/M-4363-2015; Pieretti, Stefano/I-8634-2018; Facchiano,
   Antonio/K-5984-2016
OI Norelli, Sandro/0000-0002-0176-047X; FORNI, CINZIA/0000-0002-2617-9147;
   Nisini, Roberto/0000-0003-1077-423X; Jadeja,
   Ravirajsinh/0000-0002-1712-454X; Tabolacci, Claudio/0000-0001-5001-285X;
   Pieretti, Stefano/0000-0001-5926-6194; Facchiano,
   Francesco/0000-0003-4313-0617; Beninati, Simone/0000-0002-2704-0745;
   Facchiano, Antonio/0000-0002-4243-2392
FU Italian Ministry of Health
FX The financial support from Italian Ministry of Health (Ricerca Corrente)
   is kindly acknowledged.
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NR 172
TC 314
Z9 327
U1 1
U2 36
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2314-6133
EI 2314-6141
J9 BIOMED RES INT-UK
JI Biomed Res. Int.
PY 2019
VL 2019
AR 8748253
DI 10.1155/2019/8748253
PG 16
WC Biotechnology & Applied Microbiology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Research & Experimental Medicine
GA HU4EI
UT WOS:000465226600001
PM 31080832
OA Green Published
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Takahashi, K
   Murase, T
   Takatsu, M
   Matsuura, N
   Nagasawa, K
   Hattori, T
   Watanabe, S
   Murohara, T
   Nagata, K
AF Takahashi, Keiji
   Murase, Tamayo
   Takatsu, Miwa
   Matsuura, Natsumi
   Nagasawa, Kai
   Hattori, Takuya
   Watanabe, Shogo
   Murohara, Toyoaki
   Nagata, Kohzo
TI ROLES OF OXIDATIVE STRESS AND THE MINERALOCORTICOID RECEPTOR IN CARDIAC
   PATHOLOGY IN A RAT MODEL OF METABOLIC SYNDROME
SO NAGOYA JOURNAL OF MEDICAL SCIENCE
LA English
DT Article
DE metabolic syndrome; cardiac remodeling; oxidative stress;
   mineralocorticoid receptor; renin-angiotensin-aldosterone system
ID VENTRICULAR DIASTOLIC DYSFUNCTION; HEART-FAILURE; ANIMAL-MODEL;
   DAHLS.Z-LEPR(FA)/LEPR(FA) RATS; ALDOSTERONE ANTAGONISM; ADIPOSE-TISSUE;
   PROTEIN-KINASE; ACTIVATION; HYPERTENSION; OBESITY
AB Oxidative stress and the mineralocorticoid receptor (MR) are implicated in the pathogenesis of salt-induced left ventricular (LV) diastolic dysfunction associated with metabolic syndrome (MetS). We recently characterized DahlS. Z-Leprfa/Leprfa (DS/obese) rats, derived from a cross between Dahl salt-sensitive and Zucker rats, as a new animal model of MetS. We investigated the pathophysiological roles of increased oxidative stress and MR activation in cardiac injury with this model. DS/obese rats were treated with the antioxidant tempol (1 mmol/L in drinking water) or the selective MR antagonist eplerenone (15 mg/kg per day, per os) for 5 weeks beginning at 10 weeks of age. The increased systolic blood pressure and LV hypertrophy that develop in untreated DS/obese rats were substantially ameliorated by eplerenone but not by tempol. Eplerenone also attenuated LV fibrosis and diastolic dysfunction more effectively than did tempol in DS/obese rats, whereas cardiac oxidative stress and inflammation were reduced similarly by both drugs. Both the ratio of plasma aldosterone concentration to plasma renin activity and cardiac expression of the MR and serum/glucocorticoid-regulated kinase 1 genes were decreased to a greater extent by eplerenone than by tempol. Our results indicate that both increased oxidative stress and MR activation in the heart may contribute to the development of LV remodeling and diastolic dysfunction in DS/obese rats. The superior cardioprotective action of eplerenone is likely attributable to its greater antihypertensive effect, which is likely related to its greater inhibition of aldosterone-MR activity in the cardiovascular system.
C1 [Takahashi, Keiji; Murase, Tamayo; Takatsu, Miwa; Matsuura, Natsumi; Nagasawa, Kai; Hattori, Takuya; Watanabe, Shogo; Nagata, Kohzo] Nagoya Univ, Grad Sch Med, Dept Pathophysiol Lab Sci, Nagoya, Aichi 4618673, Japan.
   [Murohara, Toyoaki] Nagoya Univ, Grad Sch Med, Dept Cardiol, Nagoya, Aichi 4618673, Japan.
C3 Nagoya University; Nagoya University
RP Nagata, K (corresponding author), Nagoya Univ, Grad Sch Med, Dept Pathophysiol Lab Sci, Higashi Ku, 1-1-20 Daikominami, Nagoya, Aichi 4618673, Japan.
EM nagata@met.nagoya-u.ac.jp
RI Murohara, Toyoaki/M-4958-2014
FU Mitsubishi Tanabe Pharma Corporation (Osaka, Japan); Kyowa Hakko Kirin
   Co. Ltd. (Tokyo, Japan); Mochida Pharmaceutical Co., Ltd. (Tokyo,
   Japan); Astellas Pharma Inc. (Tokyo, Japan); MSD K.K. (Tokyo, Japan);
   Pfizer Japan Inc. (Tokyo, Japan); Ajinomoto Pharmaceuticals Co., Ltd.
   (Tokyo, Japan); Takeda Pharmaceutical Company Limited (Osaka, Japan);
   Daiichi-Sankyo Company, Limited (Tokyo, Japan); Kowa Pharmaceutical Co.
   Ltd. (Tokyo, Japan); Nagoya University; Japanese government
FX This work was supported by unrestricted research grants from Mitsubishi
   Tanabe Pharma Corporation (Osaka, Japan), Kyowa Hakko Kirin Co. Ltd.
   (Tokyo, Japan), Mochida Pharmaceutical Co., Ltd. (Tokyo, Japan),
   Astellas Pharma Inc. (Tokyo, Japan), MSD K.K. (Tokyo, Japan), Pfizer
   Japan Inc. (Tokyo, Japan), Ajinomoto Pharmaceuticals Co., Ltd. (Tokyo,
   Japan), Takeda Pharmaceutical Company Limited (Osaka, Japan),
   Daiichi-Sankyo Company, Limited (Tokyo, Japan), Kowa Pharmaceutical Co.
   Ltd. (Tokyo, Japan) and Dr. Nagata (Nagoya University) as well as by
   Management Expenses Grants from the Japanese government to Nagoya
   University.
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NR 54
TC 6
Z9 8
U1 0
U2 4
PU NAGOYA UNIV, SCH MED
PI NAGOYA
PA EDITORIAL OFF, NAGOYA UNIV MED LIB, SCH MED, 65 TSURUMAI-CHO SHOWA- KU,
   NAGOYA, 466-8550, JAPAN
SN 2186-3326
EI 0027-7622
J9 NAGOYA J MED SCI
JI Nagoya J. Med. Sci.
PD FEB
PY 2015
VL 77
IS 1-2
BP 275
EP 289
PG 15
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA CC3IU
UT WOS:000350241400029
PM 25797993
DA 2025-06-11
ER

PT J
AU Espinosa-Moncada, J
   Marín-Echeverri, C
   Galvis-Pérez, Y
   Ciro-Gómez, G
   Aristizábal, JC
   Blesso, CN
   Fernandez, ML
   Barona-Acevedo, J
AF Espinosa-Moncada, Juliana
   Marin-Echeverri, Catalina
   Galvis-Perez, Yeisson
   Ciro-Gomez, Gelmy
   Aristizabal, Juan C.
   Blesso, Christopher N.
   Fernandez, Maria Luz
   Barona-Acevedo, Jacqueline
TI Evaluation of Agraz Consumption on Adipocytokines, Inflammation, and
   Oxidative Stress Markers in Women with Metabolic Syndrome
SO NUTRIENTS
LA English
DT Article
DE Vaccinium meridionale; metabolic syndrome; polyphenols; berries; Andean
   berry; intervention
ID C-REACTIVE PROTEIN; VACCINIUM-MERIDIONALE SWARTZ; LOW-GRADE
   INFLAMMATION; NF-KAPPA-B; ANTIOXIDANT CAPACITY; HEALTH-BENEFITS;
   BLOOD-PRESSURE; RISK-FACTORS; IN-VIVO; ADIPONECTIN
AB Metabolic syndrome (MetS) is characterized by increased oxidative stress and a pro-inflammatory state. Vaccinium meridionale Swartz (known as "agraz") is a berry rich in polyphenolic compounds with demonstrated antioxidant activity and anti-inflammatory effects in preclinical studies. The aim of this study was to evaluate the effects of agraz consumption on inflammatory and oxidative stress markers in women with MetS. Forty women with MetS (47 +/- 9 years) were randomly assigned to consume daily either 200 mL of agraz nectar or placebo over four weeks in a double-blind, cross-over design study, separated by a 4-week washout period. Metabolic and inflammatory markers in serum and antioxidant/ oxidative stress markers in serum and urine were assessed at the end of each period. Serum antioxidant capacity measured by the 2,2-diphenyl-1-picrylhydrazyl (DPPH) method was significantly higher (p = 0.028), while urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG) was lower (p = 0.041) after agraz consumption, compared to placebo. In conclusion, consumption of agraz during four weeks increased serum antioxidant capacity and decreased a marker of DNA oxidative damage in women with MetS, compared to placebo. These results suggest that agraz consumption may play a protective role in patients with MetS.
C1 [Espinosa-Moncada, Juliana; Marin-Echeverri, Catalina; Galvis-Perez, Yeisson; Ciro-Gomez, Gelmy; Barona-Acevedo, Jacqueline] Univ Antioquia UdeA, Food & Therapeut Alternat Area, Ophidism Program, Calle 70 52-21, Medellin 050010, Colombia.
   [Espinosa-Moncada, Juliana; Marin-Echeverri, Catalina; Galvis-Perez, Yeisson; Ciro-Gomez, Gelmy; Barona-Acevedo, Jacqueline] Univ Antioquia UdeA, Sch Microbiol, Calle 70 52-21, Medellin 050010, Colombia.
   [Aristizabal, Juan C.] Univ Antioquia UdeA, Res Grp PHYSIS, Sch Nutr & Dietet, Calle 70 52-21, Medellin 050010, Colombia.
   [Blesso, Christopher N.; Fernandez, Maria Luz] Univ Connecticut, Dept Nutr Sci, Storrs, CT 06269 USA.
C3 Universidad de Antioquia; Universidad de Antioquia; Universidad de
   Antioquia; University of Connecticut
RP Barona-Acevedo, J (corresponding author), Univ Antioquia UdeA, Food & Therapeut Alternat Area, Ophidism Program, Calle 70 52-21, Medellin 050010, Colombia.; Barona-Acevedo, J (corresponding author), Univ Antioquia UdeA, Sch Microbiol, Calle 70 52-21, Medellin 050010, Colombia.
EM juliana.espinosam@udea.edu.co; catalina.marin@udea.edu.co;
   yeisson.galvis@udea.edu.co; gelmy.ciro@udea.edu.co;
   juan.aristizabal@udea.edu.co; christopher.blesso@uconn.edu;
   maria-luz.fernandez@uconn.edu; maria.barona@udea.edu.co
RI Blesso, Christopher/N-9495-2014; Acevedo, Maria/A-8759-2019; Rivera,
   Juan/B-6591-2014
OI Fernandez, Maria-Luz/0000-0002-1835-0792; Galvis Perez,
   Yeisson/0000-0002-3600-2580; Aristizabal, Juan/0000-0001-5781-5903; Ciro
   Gomez, Gelmy Luz/0000-0003-2559-4776; Espinosa,
   Juliana/0000-0002-1130-5104; Barona Acevedo, Maria
   Jacqueline/0000-0002-0592-9324; Blesso, Christopher/0000-0002-4434-4839
FU Departamento Administrativo de Ciencia, Tecnologia e
   Innovacion-Colciencias [111565740563, 657]; University of Antioquia
   UdeA, Medellin-Colombia
FX This research was funded by Departamento Administrativo de Ciencia,
   Tecnologia e Innovacion-Colciencias, grant number 111565740563, Contract
   No. 657; and University of Antioquia UdeA, Medellin-Colombia.
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NR 81
TC 26
Z9 28
U1 0
U2 6
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD NOV
PY 2018
VL 10
IS 11
AR 1639
DI 10.3390/nu10111639
PG 15
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA HC1GH
UT WOS:000451547700077
PM 30400222
OA gold, Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Bettaieb, A
   Prieto, MAV
   Lanzi, CR
   Miatello, RM
   Haj, FG
   Fraga, CG
   Oteiza, PI
AF Bettaieb, Ahmed
   Vazquez Prieto, Marcela A.
   Rodriguez Lanzi, Cecilia
   Miatello, Roberto M.
   Haj, Fawaz G.
   Fraga, Cesar G.
   Oteiza, Patricia I.
TI (-)-Epicatechin mitigates high-fructose-associated insulin resistance by
   modulating redox signaling and endoplasmic reticulum stress
SO FREE RADICAL BIOLOGY AND MEDICINE
LA English
DT Article
DE Metabolic syndrome; Insulin resistance; Epicatechin and flavonoids;
   Redox signaling; NADPH oxidase; Endoplasmic reticulum stress; Free
   radicals
ID NECROSIS-FACTOR-ALPHA; BETA-CELL APOPTOSIS; FREE FATTY-ACIDS;
   FACTOR-KAPPA-B; METABOLIC SYNDROME; BLOOD-PRESSURE; NADPH OXIDASE;
   OXIDATIVE STRESS; NITRIC-OXIDE; TNF-ALPHA
AB We investigated the capacity of dietary ( - )-epicatechin (EC) to mitigate insulin resistance through the modulation of redox-regulated mechanisms in a rat model of metabolic syndrome. Adolescent rats were fed a regular chow diet without or with high fructose (HFr; 10% w/v) in drinking water for 8 weeks, and a group of HFr-fed rats was supplemented with EC in the diet. HFr-fed rats developed insulin resistance, which was mitigated by EC supplementation. Accordingly, the activation of components of the insulin signaling cascade (insulin receptor, IRSI, Ala, and ERK1/2) was impaired, whereas negative regulators (PKC, IKK, JNK, and PTP1B) were upregulated in the liver and adipose tissue of HFr rats. These alterations were partially or totally prevented by EC supplementation. In addition, EC inhibited events that contribute to insulin resistance: HFr associated increased expression and activity of NADPH oxidase, activation of redox-sensitive signals, expression of NE-kappa B-regulated proinflammatory cytokines and chemokines, and some sub-arms of endoplasmic reticulum stress signaling. Collectively, these findings indicate that EC supplementation can mitigate HFr-induced insulin resistance and are relevant for defining interventions that can prevent/mitigate MetS-associated insulin resistance. (C) 2014 Elsevier Inc. All rights reserved.
C1 [Bettaieb, Ahmed; Haj, Fawaz G.; Fraga, Cesar G.; Oteiza, Patricia I.] Univ Calif Davis, Dept Nutr, Davis, CA 95616 USA.
   [Vazquez Prieto, Marcela A.; Rodriguez Lanzi, Cecilia; Miatello, Roberto M.] Natl Univ Cuyo, Sch Med, Dept Pathol, Mendoza, Argentina.
   [Vazquez Prieto, Marcela A.; Rodriguez Lanzi, Cecilia; Miatello, Roberto M.] Consejo Nacl Invest Cient & Tecn, Inst Expt Biol & Med, Mendoza, Argentina.
   [Haj, Fawaz G.] Univ Calif Davis, Dept Internal Med, Davis, CA 95616 USA.
   [Fraga, Cesar G.] Univ Buenos Aires, CONICET, Sch Pharm & Biochem, Phys Chem IBIMOL, Buenos Aires, DF, Argentina.
   [Oteiza, Patricia I.] Univ Calif Davis, Dept Environm Toxicol, Davis, CA 95616 USA.
C3 University of California System; University of California Davis;
   University Nacional Cuyo Mendoza; Consejo Nacional de Investigaciones
   Cientificas y Tecnicas (CONICET); University of California System;
   University of California Davis; University of Buenos Aires; Consejo
   Nacional de Investigaciones Cientificas y Tecnicas (CONICET); University
   of California System; University of California Davis
RP Oteiza, PI (corresponding author), Univ Calif Davis, Dept Nutr, Davis, CA 95616 USA.
EM poteiza@ucdavis.edu
RI Prieto, Marcela/W-4291-2019; Fraga, Cesar/Q-8161-2019; Stefanadis,
   Christodoulos/ABH-2232-2020
OI Stefanadis, Christodoulos/0000-0001-5974-6454; Fraga, Cesar
   G./0000-0003-4168-9927; Rodriguez Lanzi, Maria
   Cecilia/0000-0002-4878-0427
FU University of California at Davis, NIFA [CA-D-XXX-7244-H]; JDRF
   [1-2009-337]; NIH USA [R56DK084317, R01DK090492, 1K99DK100736]; Programa
   I + D 2010 Universidad Nacional de Cuyo; PICT; PIP [11220120100558];
   Ubacyt Argentina [20020120100177]
FX This work was supported by the University of California at Davis, NIFA
   CA-D-XXX-7244-H to P.I.O.; research grants from JDRF (1-2009-337) and
   NIH Grants R56DK084317 and R01DK090492 to F.G.H.; 1K99DK100736 to A.B.;
   USA. PICT 2011-1957; and Programa I + D 2010 Universidad Nacional de
   Cuyo, PIP 11220120100558, and Ubacyt 20020120100177, ArgentinaM
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NR 70
TC 110
Z9 116
U1 1
U2 30
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0891-5849
EI 1873-4596
J9 FREE RADICAL BIO MED
JI Free Radic. Biol. Med.
PD JUL
PY 2014
VL 72
BP 247
EP 256
DI 10.1016/j.freeradbiomed.2014.04.011
PG 10
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA AJ4OS
UT WOS:000337656300023
PM 24746618
OA Green Published, Green Accepted
DA 2025-06-11
ER

PT J
AU Hapala, I
   Marza, E
   Ferreira, T
AF Hapala, Ivan
   Marza, Esther
   Ferreira, Thierry
TI Is fat so bad? Modulation of endoplasmic reticulum stress by lipid
   droplet formation
SO BIOLOGY OF THE CELL
LA English
DT Review
DE lipotoxicity; metabolic syndrome; obesity; saturated fatty acid; Type 2
   diabetes; unfolded protein response (UPR)
ID YEAST SACCHAROMYCES-CEREVISIAE; UNFOLDED PROTEIN RESPONSE; PANCREATIC
   BETA-CELLS; INDUCED ER STRESS; ACID-INDUCED LIPOTOXICITY; HEPATIC
   STEATOSIS; TRIGLYCERIDE ACCUMULATION; CYTOPROTECTIVE ACTIONS; INSULIN
   STIMULATION; METABOLIC SYNDROME
AB LDs (lipid droplets) have long been considered as inert particles used by the cells to store fatty acids and sterols as esterified non-toxic lipid species (i.e. triacylglycerols and steryl esters). However, accumulating evidence suggests that LDs behave as a dynamic compartment, which is involved in the regulation of several aspects of the homoeostasis of their originating organelle, namely the ER (endoplasmic reticulum). The ER is particularly sensitive to physiological/pathological stimuli, which can ultimately induce ER stress. In the present review, after considering the basic mechanisms of LD formation and the signal cascades leading to ER stress, we focus on the connections between these two pathways. Taking into consideration recent data from the literature, we will try to draw possible mechanisms for the role of LDs in the regulation of ER homoeostasis and in ER-stress-related diseases.
C1 [Ferreira, Thierry] Univ Poitiers, Inst Physiol & Biol Cellulaires, CNRS, UMR 6187, F-86022 Poitiers, France.
   [Marza, Esther] Univ Bordeaux 2, INSERM, U1053, F-33076 Bordeaux, France.
   [Hapala, Ivan] Slovak Acad Sci, Inst Anim Biochem & Genet, Ivanka Pri Dunaji 90028, Slovakia.
C3 Centre National de la Recherche Scientifique (CNRS); Universite de
   Poitiers; Universite de Bordeaux; Institut National de la Sante et de la
   Recherche Medicale (Inserm); Slovak Academy of Sciences; Institute of
   Animal Biochemistry & Genetics, SAS
RP Ferreira, T (corresponding author), Univ Poitiers, Inst Physiol & Biol Cellulaires, CNRS, UMR 6187, 1 Rue Georges Bonnet,BP 633, F-86022 Poitiers, France.
EM thierry.ferreira@univ-poitiers.fr
RI Hapala, Ivan/ABB-5807-2021
FU Slovak Agency for Science and Technology [APVV-0681-07]; Association de
   Recherche contre le Cancer (ARC); French MENRT; Region Poitou-Charentes;
   CNRS
FX Work by the authors is supported by the Slovak Agency for Science and
   Technology [grant number APVV-0681-07 (to I.H)]; the Association de
   Recherche contre le Cancer (ARC) (to E.M.); and by the French MENRT, the
   Region Poitou-Charentes and the CNRS (to T.F.).
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NR 102
TC 92
Z9 101
U1 2
U2 33
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0248-4900
J9 BIOL CELL
JI Biol. Cell
PD JUN
PY 2011
VL 103
IS 6
BP 271
EP 285
DI 10.1042/BC20100144
PG 15
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA 799WC
UT WOS:000293315800002
PM 21729000
OA Bronze
DA 2025-06-11
ER

PT J
AU Lu, YL
   Zhao, AQ
   Wu, YM
   Zhao, Y
   Yang, XB
AF Lu, Yalong
   Zhao, Aiqing
   Wu, Yingmei
   Zhao, Yan
   Yang, Xingbin
TI Soybean soluble polysaccharides enhance bioavailability of genistein and
   its prevention against obesity and metabolic syndrome of mice with
   chronic high fat consumption
SO FOOD & FUNCTION
LA English
DT Article
ID DIET-INDUCED OBESITY; OXIDATIVE STRESS; MOLECULAR-MECHANISMS; GUT
   MICROBIOME; PPAR-ALPHA; LIVER; INFLAMMATION; MODULATION; ADIPOKINES;
   RESISTANCE
AB This study aimed to explore a novel strategy for the simultaneous consumption of soluble soybean polysaccharides (SSPS) and insoluble genistein to improve the bioavailability of genistein and its prevention against obesity and metabolic syndrome in high-fat diet (HFD)-induced obese mice. C57BL/6J mice were fed a normal diet and HFD supplemented or not (n = 8) with SSPS (2.5%), genistein (0.5%) and their mixture (S + G) for 12 weeks. The UPLC-qTOP/MS assay showed that SSPS observably enhanced the urinary concentration of genistein and its metabolites compared to that of single genistein in mice. Supplementation of SSPS, genistein or their combination prevented HFD-induced gain weight, dyslipidemia, oxidative stress and inflammation in obese mice. Interestingly, the combined S + G ingestion exhibited more effective alleviation of dyslipidemia by modulating hepatic FAS, ACC, SREBP-1C and ADRP expressions relative to that of individual SSPS or genistein. Furthermore, S + G activated the energy metabolism pathway AMPK in the liver, and the hepatic PPAR-alpha/PPAR-gamma pathways were doubly activated to alleviate lipogenesis, inflammation, obesity and metabolic syndrome. Moreover, S + G supplementation dramatically modified the gut microbial species at the phylum level with a decrease in Firmicutes and increase in Bacteroidetes. These findings support that the combined supplementation of SSPS and genistein is a novel couple to prevent obesity and metabolic syndrome.
C1 [Lu, Yalong; Zhao, Aiqing; Wu, Yingmei; Yang, Xingbin] Shaanxi Normal Univ, Coll Food Engn & Nutr Sci, Shaanxi Engn Lab Food Green Proc & Safety Control, Xian 710119, Shaanxi, Peoples R China.
   [Lu, Yalong; Zhao, Aiqing; Wu, Yingmei; Yang, Xingbin] Shaanxi Normal Univ, Coll Food Engn & Nutr Sci, Shaanxi Key Lab Hazard Factors Assessment Proc &, Xian 710119, Shaanxi, Peoples R China.
   [Zhao, Yan] Shaanxi Normal Univ, Minist Educ Med Resource & Nat Pharmaceut Chem, Key Lab, Xian 710062, Shaanxi, Peoples R China.
C3 Shaanxi Normal University; Shaanxi Normal University; Shaanxi Normal
   University
RP Zhao, AQ; Yang, XB (corresponding author), Shaanxi Normal Univ, Coll Food Engn & Nutr Sci, Shaanxi Engn Lab Food Green Proc & Safety Control, Xian 710119, Shaanxi, Peoples R China.; Zhao, AQ; Yang, XB (corresponding author), Shaanxi Normal Univ, Coll Food Engn & Nutr Sci, Shaanxi Key Lab Hazard Factors Assessment Proc &, Xian 710119, Shaanxi, Peoples R China.
EM aiqing_zhao@hotmail.com; xbyang@snnu.edu.cn
OI Yang, xingbin/0000-0002-8039-0525; zhao, yan/0000-0002-7829-5975; Lu,
   Yalong/0000-0001-5792-4819
FU National Natural Science Foundation of China [C31671823, C31871752];
   Fundamental Research Funds for the Central Universities of Shaanxi
   Normal University, China [2018CBLZ004, GK201803074]; Development Program
   for Innovative Research Team of Shaanxi Normal University, China
   [GK201801002]; Key Research and Development Plan in Shaanxi Province,
   China [2017NY-102]
FX This study was supported by grants from the National Natural Science
   Foundation of China (C31671823 and C31871752), the Fundamental Research
   Funds for the Central Universities of Shaanxi Normal University, China
   (2018CBLZ004, GK201803074), the Development Program for Innovative
   Research Team of Shaanxi Normal University, China (GK201801002), as well
   as the Key Research and Development Plan in Shaanxi Province, China
   (2017NY-102).
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NR 47
TC 44
Z9 52
U1 1
U2 98
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PD JUL 1
PY 2019
VL 10
IS 7
BP 4153
EP 4165
DI 10.1039/c8fo02379d
PG 13
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA IK6GK
UT WOS:000476683600029
PM 31241065
DA 2025-06-11
ER

PT J
AU Fagerberg, B
   Bokemark, L
   Hulthe, J
AF Fagerberg, B
   Bokemark, L
   Hulthe, J
TI The metabolic syndrome, smoking, and antibodies to oxidized LDL in
   58-year-old clinically healthy men
SO NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
LA English
DT Article
DE LDL; antibody titer; metabolic syndrome; smoking
ID LOW-DENSITY-LIPOPROTEIN; CORONARY HEART-DISEASE; INSULIN-RESISTANCE;
   OXIDATIVE STRESS; PLASMA-LIPOPROTEINS; PARTICLE-SIZE; ATHEROSCLEROSIS;
   RISK; AUTOANTIBODIES; SUSCEPTIBILITY
AB Background and Aim: The aim was to examine whether the metabolic syndrome (as recently, defined), its various components, and smoking were associated with circulating antibodies to oxidized low-density lipoproteins (IgG- and IgM-Ox-LDLAb) and malondialdehyde-treated LDL (IgG- and IgM-MDA-LDLAb) (ELISA) in a population sample of clinically, healthy 58-year-old men (n=391).
   Methods and Results: LDL peak particle size (gradient gel electrophoresis) and antibody, titers were measured in all patients. Trend analysis showed significantly higher IgG-Ox-LDLAb and IgG-MDA-LDLAb titers across the range of men with none of the criteria defining metabolic syndrome (n=77), those with greater than or equal to criterion (n=252) and those fulfilling the criteria (n=62), which remained after adjustment for smoking. IgG-Ox-LDLAb was associated with plasma insulin, body mass index (BMI), the waist/hip ratio (WHR) and smoking. IgG-MDA-LDLAb was, in addition, related to diastolic blood pressure, serum triglycerides and a small LDL peak particle size. The IgM antibody titers only inversely correlated with smoking.
   Conclusions: High serum titers of IgG antibodies to oxidized LDL and MDA-treated LDL were associated with the metabolic syndrome and smoking. Several of the factors in the metabolic syndrome were related to the IgG antibody titers to modified LDL. The high degree of intercorrelation among these factors makes it difficult to clarify the independent role of any specific factor. ((C))2001, Medikal Press.
C1 Gothenburg Univ, Sahlgrens Hosp, Wallenberg Lab Cardiovasc Res, S-41345 Gothenburg, Sweden.
   Gothenburg Univ, Sahlgrens Hosp, Dept Med, S-41345 Gothenburg, Sweden.
C3 University of Gothenburg; Sahlgrenska University Hospital; Sahlgrenska
   University Hospital; University of Gothenburg
RP Hulthe, J (corresponding author), Gothenburg Univ, Sahlgrens Hosp, Wallenberg Lab Cardiovasc Res, S-41345 Gothenburg, Sweden.
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NR 42
TC 13
Z9 15
U1 0
U2 0
PU MEDIKAL PRESS S R L
PI MILAN
PA VIA LUIGI ZOJA, 30, 20153 MILAN, ITALY
SN 0939-4753
J9 NUTR METAB CARDIOVAS
JI Nutr. Metab. Carbiovasc. Dis.
PD AUG
PY 2001
VL 11
IS 4
BP 227
EP 235
PG 9
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism; Nutrition
   & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism;
   Nutrition & Dietetics
GA 503TZ
UT WOS:000172818200004
PM 11831108
DA 2025-06-11
ER

PT J
AU Miedlich, SU
   Sahay, P
   Olivares, TE
   Lamberti, JS
   Morse, DS
   Brazill, KP
   Chhabra, KH
   Bainbridge, L
AF Miedlich, Susanne U.
   Sahay, Priya
   Olivares, Telva E.
   Lamberti, J. Steven
   Morse, Diane S.
   Brazill, Kevin P.
   Chhabra, Kavaljit H.
   Bainbridge, Lauren
TI Lifestyle and mood correlates of cardiometabolic risk in people with
   serious mental illness on second-generation antipsychotic medications
SO PLOS ONE
LA English
DT Article
ID HEART-RATE-VARIABILITY; C-REACTIVE PROTEIN; DIABETES-MELLITUS;
   CARDIOVASCULAR RISK; SEDENTARY BEHAVIOR; INSULIN-RESISTANCE; METABOLIC
   SYNDROME; PHYSICAL-ACTIVITY; BIPOLAR DISORDER; SCHIZOPHRENIA
AB Introduction Cardiovascular morbidity and mortality are high in people with serious mental illness (SMI). This problem is mediated, at least in part, by metabolic side effects of second-generation antipsychotics (SGAs) and by unhealthy lifestyle behaviors. We asked whether oral glucose tolerance testing (oGTT) or hemoglobin A1c (HbA1c) is superior in identifying people with SMI at high cardiometabolic risk and whether this risk is shaped by mood, cognition, or lifestyle habits. Methods We evaluated 40 patients with schizophrenia, schizoaffective, or bipolar disorder receiving SGAs by oGTT, HbA1c, comprehensive metabolic and lipid panels, and CRP. Mood was assessed using the Patient Health Questionnaire (PHQ-9), and cognition was assessed using the Saint Louis University Mental Status examination. Diet was assessed using the UK Diabetes and Diet Questionnaire (UKDDQ), and physical activity was assessed using daily step counts. Results Most patients had prediabetes (preDM) or diabetes mellitus (DM), 72.5% by oGTT, and 52.5% by HbA1c criteria. Pulse rates and insulin resistance indices (Homeostatic Model Assessment of Insulin Resistance, HOMA IR; Matsuda) were significantly different between patients classified as normal or with preDM/DM, using either oGTT or HbA1c criteria. Patients with preDM/DM by HbA1c but not oGTT criteria also had higher waist/hip ratios, triglyceride, and CRP levels (p<0.05). A strong negative correlation was found between average daily step counts and CRP levels (rho = -0.62, p<0.001). Higher UKDDQ scores, or unhealthier diet habits, were associated with higher fasting plasma glucose (rho = 0.28, p = 0.08), triglyceride levels (rho = 0.31, p = 0.05), and insulin resistance (HOMA IR: rho = 0.31, p = 0.06). Higher PHQ-9 scores correlated with lower 2h-oGTT glucose levels (rho = -0.37, p<0.05). Conclusions OGTT screening is superior to HbA1c screening in detecting preDM and DM early. Patients identified with preDM/DM by oGTT or HbA1c screening are insulin-resistant and have higher pulse rates. Abdominal obesity, unfavorable lipid profiles, and higher CRP levels were noted in patients screened by HbA1c, but not by oGTT. Low physical activity, low depression scores, and unhealthy diet habits were associated with higher CRP and higher glucose and triglyceride levels, respectively. Future studies should assess the impact of specifically tailored individual lifestyle counseling and medical management interventions in this high-risk population.
C1 [Miedlich, Susanne U.; Bainbridge, Lauren] Univ Rochester, Sch Med & Dent, Dept Med, Div Endocrinol & Metab, Rochester, NY 14627 USA.
   [Sahay, Priya] Phoel Associates Inc, Toms River, NJ USA.
   [Olivares, Telva E.; Lamberti, J. Steven; Morse, Diane S.; Brazill, Kevin P.] Univ Rochester, Sch Med & Dent, Dept Psychiat, Rochester, NY USA.
   [Morse, Diane S.] Univ Rochester, Sch Med & Dent, Dept Med, Rochester, NY USA.
   [Chhabra, Kavaljit H.] Univ Kentucky, Coll Med, Dept Pharmacol & Nutr Sci, Lexington, KY USA.
C3 University of Rochester; University of Rochester; University of
   Rochester; University of Kentucky
RP Miedlich, SU (corresponding author), Univ Rochester, Sch Med & Dent, Dept Med, Div Endocrinol & Metab, Rochester, NY 14627 USA.
EM susanne_miedlich@urmc.rochester.edu
RI Chhabra, Kavaljit/LVR-5484-2024; Chhabra, Kavaljit/P-6461-2015
OI Miedlich, Susanne/0000-0003-1024-0959; Chhabra,
   Kavaljit/0000-0001-6378-3645
FU University of Rochester Medical Center Department of Medicine
FX SUM: Pilot award from the University of Rochester Medical Center
   Department of Medicine. URL:https://www.urmc.rochester.edu/medicine.aspx
   The sponsordid not play a role in studydesign,data
   collection,analysis,decisiontopublishor preparationof the manuscript.
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NR 53
TC 2
Z9 2
U1 0
U2 1
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD AUG 9
PY 2024
VL 19
IS 8
AR e0306798
DI 10.1371/journal.pone.0306798
PG 16
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA C3Z2Y
UT WOS:001288771300061
PM 39121088
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Sánchez-Rodríguez, MA
   Zacarías-Flores, M
   Castrejón-Delgado, L
   Ruiz-Rodríguez, AK
   Mendoza-Núñez, VM
AF Sanchez-Rodriguez, Martha A.
   Zacarias-Flores, Mariano
   Castrejon-Delgado, Lizett
   Karen Ruiz-Rodriguez, Ana
   Manuel Mendoza-Nunez, Victor
TI Effects of Hormone Therapy on Oxidative Stress in Postmenopausal Women
   with Metabolic Syndrome
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE oxidative stress; hormone therapy; postmenopause; metabolic syndrome;
   lipids profile
ID REPLACEMENT THERAPY; RISK-FACTORS; MENOPAUSE; PLACEBO; OBESITY; PLASMA;
   LIPOPROTEINS; HEALTH; ADULTS; LDL
AB The aim of this study was to determine the effect of oral hormone therapy (HT) on oxidative stress (OS) in postmenopausal women with metabolic syndrome (MetS). A randomized, double blind, placebo-controlled trial was carried out. We formed four groups of 25 women each; healthy (HW) and MetS women (MSW) were assigned to HT (1 mg/day of estradiol valerate plus 5 mg/10 day of medroxiprogesterone) or placebo. We measured plasma lipoperoxides, erythrocyte superoxide dismutase and glutathione peroxidase, total plasma antioxidant status and uric acid, as OS markers. Alternative cut-off values of each parameter were defined and a stress score (SS) ranging from 0 to 7 was used as total OS. MetS was defined according to National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATPIII) criteria. Participants were seen at baseline, 3 and 6 months. After 6 months, MetS decreased in MSW-HT (48%), their triglycerides and high-density lipoprotein cholesterol (HDL-c) improved; in the other groups no difference was found. SS in MSW-HT decreased (3.8 +/- 0.3 to 1.7 +/- 0.3, p < 0.05) and OS was also reduced (44%), this effect was evident since 3 mo. HW-HT with high OS also decreased (40%). In placebo groups there was no change. Our findings suggest that HT improve lipids and OS associated to MetS in postmenopausal women.
C1 [Sanchez-Rodriguez, Martha A.; Castrejon-Delgado, Lizett; Karen Ruiz-Rodriguez, Ana; Manuel Mendoza-Nunez, Victor] Univ Nacl Autonoma Mexico, Fac Estudios Super Zaragoza, Unidad Invest Gerontol, Guelatao 66, Mexico City 09230, DF, Mexico.
   [Zacarias-Flores, Mariano] Hosp Gen Dr Gustavo Baz Prada, Inst Salud Estado Mexico, Div Ginecol & Obstet, Ave Bordo Xochiaca Esq Adolfo Lopez Mateos S-N, Mexico City 57300, DF, Mexico.
C3 Universidad Nacional Autonoma de Mexico
RP Mendoza-Núñez, VM (corresponding author), Univ Nacl Autonoma Mexico, Fac Estudios Super Zaragoza, Unidad Invest Gerontol, Guelatao 66, Mexico City 09230, DF, Mexico.
EM masanrod@yahoo.com.mx; mzacariasf@yahoo.com;
   lizettcastrejon@hotmail.com; hikary90@hotmail.com; mendovic@unam.mx
RI Mendoza-Núñez, Víctor Manuel/AFL-2465-2022; Sanchez-Rodriguez,
   Martha/N-3528-2017
OI Zacarias Flores, Mariano/0000-0002-0362-5191; Castrejón-Delgado,
   Lizett/0000-0001-5504-2353; Ruiz-Rodriguez, Ana
   Karen/0000-0003-0964-1827; Sanchez-Rodriguez, Martha/0000-0002-7130-4074
FU Direccion General de Asuntos del Personal Academico, Universidad
   Nacional Autonoma de Mexico (DGAPA, UNAM) [PAPIIT IN222213]
FX Trial registration: COF000120, Secretaria de Salud, Mexico. This work
   was supported by grant from Direccion General de Asuntos del Personal
   Academico, Universidad Nacional Autonoma de Mexico (DGAPA, UNAM), PAPIIT
   IN222213.
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NR 43
TC 10
Z9 11
U1 0
U2 7
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD SEP
PY 2016
VL 17
IS 9
AR 1388
DI 10.3390/ijms17091388
PG 15
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA DZ0JU
UT WOS:000385525500016
PM 27563883
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Corsetti, G
   Pasini, E
   Ferrari-Vivaldi, M
   Romano, C
   Bonomini, F
   Tasca, G
   Dioguardi, FS
   Rezzani, R
   Assanelli, D
AF Corsetti, G.
   Pasini, E.
   Ferrari-Vivaldi, M.
   Romano, C.
   Bonomini, F.
   Tasca, G.
   Dioguardi, F. S.
   Rezzani, R.
   Assanelli, D.
TI METABOLIC SYNDROME AND CHRONIC SIMVASTATIN THERAPY ENHANCED HUMAN
   CARDIOMYOCYTE STRESS BEFORE AND AFTER ISCHEMIA-REPERFUSION IN
   CARDIO-PULMONARY BYPASS PATIENTS
SO INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY
LA English
DT Article
DE heart; metabolic syndrome; ischemia-reperfusion damage; statin side
   effects
ID HEAT-SHOCK RESPONSE; PICROSIRIUS RED; OVEREXPRESSION; MITOCHONDRIA;
   RESPIRATION; INHIBITION; PROTECTION; APOPTOSIS; INJURY
AB Metabolic syndrome (MetS) is a set of metabolic alterations including high levels of low-density lipoprotein (LDL), which increase the risk of cardiomyopathy often leading to surgery. Despite inducing myopathy, statins are widely used to lower LDL. Cardiopulmonary bypass (Cpb) causes oxidative stress and metabolic injury, altering mitochondrial expression (Grp75) and endoplasmic reticulum (Grp78) chaperones, apoptotic enzymes (Bcl2 family) and increasing cardiomyocyte lipid/lipofuscin storage. We believe that cardiomyocytes from patients with MetS may be more sensitive to surgical stress, in particular after simvastatin therapy (MetS+Stat). The study group included ten patients with MetS, ten patients with Mets+Stat and ten healthy subjects. Myocardial biopsies were obtained both before and after-Cpb. Grp75, Grp78, Bax, Bcl2, lipids, lipofuscin and fibrosis were evaluated by immuno/histochemistry. MetS cardiomyocytes had higher Grp75, Bax, fibrosis and lipofuscin. MetS+Stat had lower Grp75 and higher Grp78 expressions, high Bax, fewer fibrosis and higher lipofuscin content. Cpb did not vary the fibrosis and lipids/lipofuscin content, although it influenced the chaperones and Bax expression in all groups. These changes were more profound in patients with MetS and even more so in patients with MetS+Stat. The results suggest that MetS and MetS+Stat cardiomyocytes were more highly stressed after-Cpb. Interestingly, simvastatin caused high stress even before-Cpb.
C1 [Corsetti, G.; Bonomini, F.; Rezzani, R.] Univ Brescia, Dept Clin & Expt Sci, Div Human Anat, I-25124 Brescia, Italy.
   [Pasini, E.] S Maugeri Fdn IRCCS, Med Ctr, Brescia, Italy.
   [Ferrari-Vivaldi, M.] San Rocco Hosp, Dept Cardiovasc Surg, Brescia, Italy.
   [Romano, C.; Assanelli, D.] Univ Brescia, Dept Clin & Expt Sci, Div Internal Med, I-25124 Brescia, Italy.
   [Tasca, G.] A Manzoni Hosp, Div Cardiac Surg, Lecce, Italy.
   [Dioguardi, F. S.] Univ Milan, Dept Internal Med, Milan, Italy.
C3 University of Brescia; Istituti Clinici Scientifici Maugeri IRCCS;
   University of Brescia; University of Milan
RP Corsetti, G (corresponding author), Univ Brescia, Dept Clin & Expt Sci, Div Human Anat, Viale Europa 11, I-25124 Brescia, Italy.
EM corsetti@med.unibs.it
RI Francesca, Bonomini/E-9931-2010; Pasini, Evasio/AAC-1798-2020; Corsetti,
   Giovanni/E-7713-2010; Dioguardi, Francesco Saverio/B-4422-2017
OI Pasini, Evasio/0000-0003-2836-4490; Tasca, Giordano/0000-0002-0702-6145;
   Bonomini, Francesca/0000-0001-7210-0308; Corsetti,
   Giovanni/0000-0003-0326-0644; Dioguardi, Francesco
   Saverio/0000-0003-0445-3106
FU University of Brescia
FX This work is dedicated to the memory of Dr. Gianna Ferrari-Vivaldi and
   was supported by grants from the University of Brescia (to G.C.). We
   would like also to thank Doll. Robert Coates (Lecturer and medical
   writer, Centro Linguistico Bocconi University, Milano), for his
   linguistic revision.
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NR 35
TC 4
Z9 4
U1 0
U2 3
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0394-6320
EI 2058-7384
J9 INT J IMMUNOPATH PH
JI Int. J. Immunopathol. Pharmacol.
PD OCT-DEC
PY 2012
VL 25
IS 4
BP 1063
EP 1074
DI 10.1177/039463201202500423
PG 12
WC Immunology; Pathology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Pathology; Pharmacology & Pharmacy
GA 074YK
UT WOS:000313850800023
PM 23298496
DA 2025-06-11
ER

PT J
AU Carillon, J
   Jover, B
   Cristol, JP
   Rouanet, JM
   Richard, S
   Virsolvy, A
AF Carillon, Julie
   Jover, Bernard
   Cristol, Jean-Paul
   Rouanet, Jean-Max
   Richard, Sylvain
   Virsolvy, Anne
TI Dietary supplementation with a specific melon concentrate reverses
   vascular dysfunction induced by cafeteria diet
SO FOOD & NUTRITION RESEARCH
LA English
DT Article
DE vascular function; oxidative stress; antioxidant; superoxide dismutase;
   obesity
ID HIGH-FAT DIET; SPONTANEOUSLY HYPERTENSIVE-RATS; METABOLIC SYNDROME;
   SUPEROXIDE-DISMUTASE; OXIDATIVE STRESS; ENDOTHELIAL FUNCTION; DIFFERENT
   MECHANISMS; INSULIN-RESISTANCE; NAD(P)H OXIDASE; EXTRACT RICH
AB Background: Obesity-related metabolic syndrome is associated with high incidence of cardiovascular diseases partially consecutive to vascular dysfunction. Therapeutic strategies consisting of multidisciplinary interventions include nutritional approaches. Benefits of supplementation with a specific melon concentrate, enriched in superoxide dismutase (SOD), have previously been shown on the development of insulin resistance and inflammation in a nutritional hamster model of obesity.
   Objective: We further investigated arterial function in this animal model of metabolic syndrome and studied the effect of melon concentrate supplementation on arterial contractile activity.
   Design and results: The study was performed on a hamster model of diet-induced obesity. After a 15-week period of cafeteria diet, animals were supplemented during 4 weeks with a specific melon concentrate (Cucumis melo L.) Contractile responses of isolated aorta to various agonists and antagonists were studied ex vivo. Cafeteria diet induced vascular contractile dysfunction associated with morphological remodeling. Melon concentrate supplementation partially corrected these dysfunctions; reduced morphological alterations; and improved contractile function, especially by increasing nitric oxide bioavailability and expression of endogenous SOD.
   Conclusions: Supplementation with the specific melon concentrate improves vascular dysfunction associated with obesity. This beneficial effect may be accounted for by induction of endogenous antioxidant defense. Such an approach in line with nutritional interventions could be a useful strategy to manage metabolic syndrome-induced cardiovascular trouble.
C1 [Carillon, Julie; Rouanet, Jean-Max] Univ Montpellier, Nutr & Metab, UMR 204 NutriPass, Montpellier, France.
   [Carillon, Julie] Bionov Res, Montpellier, France.
   [Jover, Bernard] Univ Montpellier, EA7288, Montpellier, France.
   [Jover, Bernard; Cristol, Jean-Paul; Richard, Sylvain; Virsolvy, Anne] Univ Montpellier, CNRS, INSERM U1046, UMR 9214,PhysMedExp, F-34059 Montpellier, France.
C3 Institut de Recherche pour le Developpement (IRD); Universite de
   Montpellier; Universite de Montpellier; Centre National de la Recherche
   Scientifique (CNRS); CNRS - National Institute for Biology (INSB);
   Institut National de la Sante et de la Recherche Medicale (Inserm);
   Universite de Montpellier
RP Virsolvy, A (corresponding author), CHU Arnaud Villeneuve, CNRS, INSERM U1046, UMR 9214, FR-34495 Montpellier, France.
EM anne.virsolvy@inserm.fr
RI Richard, Sylvain/C-9695-2016; VIRSOLVY, Anne/E-4964-2016
OI VIRSOLVY, Anne/0000-0002-5819-3306; , Jean-Paul
   Cristol/0000-0001-8563-7278; JOVER, Bernard/0000-0001-5826-5755;
   Richard, Sylvain/0000-0001-9460-6705
FU Bionov Company with a CIFRE fellowship
FX JC was financially supported by Bionov Company with a CIFRE fellowship
   (Industrial Agreement of Training Through Research).
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NR 42
TC 8
Z9 8
U1 0
U2 4
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1654-6628
EI 1654-661X
J9 FOOD NUTR RES
JI Food Nutr. Res.
PY 2016
VL 60
AR 32729
DI 10.3402/fnr.v60.32729
PG 9
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA EO7OW
UT WOS:000396881000001
PM 27834185
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Rana, R
   Kamath, SU
   Shastri, BA
   Shashikiran, U
   Maiya, GA
   Kamath, U
   Rao, SR
   Lakshmi, RV
AF Rana, Raju
   Kamath, Shobha U.
   Shastri, B. Ananthakrishna
   Shashikiran, U.
   Maiya, G. Arun
   Kamath, Ullas
   Rao, S. Raghavendra
   Lakshmi, R. Vani
TI Evaluation of thiol/disulfide homeostasis and ischemia-modified albumin
   in metabolic syndrome patients
SO ADVANCES IN REDOX RESEARCH
LA English
DT Article
DE Dynamic thiol-disulfide homeostasis; Dyslipidemia; Ischemia-modified
   albumin; Metabolic syndrome; Oxidative stress
ID OXIDATIVE STRESS; OBESITY; MARKER; THIOLS; REDOX; ASSAY
AB Introduction: Ischemia-modified albumin (IMA) and thiol-disulfide homeostasis (TDH) have emerged as valuable markers of oxidative stress in various disease states, including diabetic nephropathy. However, limited research has been conducted on these markers in individuals with metabolic syndrome (MetS), particularly those with comorbid type 2 diabetes mellitus (T2DM). This study aims to investigate the roles of TDH and IMA in the context of MetS. Materials and methods: We enrolled 162 participants, comprising three groups of 54 subjects each: healthy controls, patients with MetS alone, and patients with both MetS and T2DM. IMA levels and TDH parameters were measured spectrophotometrically. Statistical analyses included one-way analysis of variance (ANOVA) and correlation studies. Results: IMA levels were significantly elevated, and thiol levels were significantly reduced in participants with MetS compared to healthy controls (P < 0.001). IMA levels showed a strong positive association with diastolic blood pressure and fasting blood glucose (FBG) (P < 0.001). High-density lipoprotein cholesterol, native thiol, and total thiol were also strongly associated (P < 0.001). In contrast, triglycerides, waist circumference, and FBG were negatively correlated with thiol levels. Conclusion: Our findings demonstrated elevated oxidative stress in patients with MetS, as evidenced by increased IMA levels and decreased thiol concentrations. These parameters may be valuable markers for monitoring disease progression and potential complications in MetS.
C1 [Rana, Raju; Kamath, Shobha U.] Manipal Acad Higher Educ, Kasturba Med Coll, Dept Biochem, Manipal 576104, Karnataka, India.
   [Shastri, B. Ananthakrishna; Rao, S. Raghavendra] Manipal Acad Higher Educ, Kasturba Med Coll, Dept Med, Manipal 576104, Karnataka, India.
   [Shashikiran, U.] Manipal Acad Higher Educ, Melaka Manipal Med Coll, Dept Med, Manipal 576104, Karnataka, India.
   [Maiya, G. Arun] Manipal Acad Higher Educ, Manipal Coll Hlth Profess, Dept Physiotherapy, Manipal 576104, Karnataka, India.
   [Kamath, Ullas] Manipal Acad Higher Educ, Melaka Manipal Med Coll, Dept Biochem, Manipal 576104, Karnataka, India.
   [Lakshmi, R. Vani] Manipal Acad Higher Educ, Prasanna Sch Publ Hlth, Dept Data Sci, Manipal 576104, Karnataka, India.
C3 Manipal Academy of Higher Education (MAHE); Kasturba Medical College,
   Manipal; Manipal Academy of Higher Education (MAHE); Kasturba Medical
   College, Manipal; Manipal Academy of Higher Education (MAHE); Manipal
   Academy of Higher Education (MAHE); Manipal Academy of Higher Education
   (MAHE); Manipal Academy of Higher Education (MAHE)
RP Kamath, SU (corresponding author), Manipal Acad Higher Educ, Kasturba Med Coll, Dept Biochem, Manipal 576104, Karnataka, India.
EM raju.rana1@learner.manipal.edu; shobha.kamath@manipal.edu;
   ba.shastry@manipal.edu; shashikiran.u@manipal.edu;
   arun.maiya@manipal.edu; ullas.kamath@manipal.edu; rags.rao@manipal.edu;
   vani.lakshmi@manipal.edu
RI R, Vani/AAF-4026-2021; Umakanth, Shashikiran/K-5036-2015
CR Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
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NR 36
TC 0
Z9 0
U1 3
U2 3
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
EI 2667-1379
J9 ADV REDOX RES
JI Adv. Redox Res.
PD MAR
PY 2025
VL 14
AR 100116
DI 10.1016/j.arres.2024.100116
EA DEC 2024
PG 6
WC Biochemistry & Molecular Biology
WE Emerging Sources Citation Index (ESCI)
SC Biochemistry & Molecular Biology
GA Q7U2D
UT WOS:001386673100001
OA gold
DA 2025-06-11
ER

PT J
AU Otunctemur, A
   Dursun, M
   Ozbek, E
   Sahin, S
   Besiroglu, H
   Koklu, I
   Erkoc, M
   Danis, E
   Bozkurt, M
AF Otunctemur, Alper
   Dursun, Murat
   Ozbek, Emin
   Sahin, Suleyman
   Besiroglu, Huseyin
   Koklu, Ismail
   Erkoc, Mustafa
   Danis, Eyyup
   Bozkurt, Muammer
TI Impact of metabolic syndrome on stress urinary incontinence in pre- and
   postmenopausal women
SO INTERNATIONAL UROLOGY AND NEPHROLOGY
LA English
DT Article
DE Stress urinary incontinence; Metabolic syndrome; Menopaus; Glucose; Body
   mass index
ID RISK-FACTORS; WAIST CIRCUMFERENCE; SERUM ESTRADIOL; PELVIC FLOOR;
   PREVALENCE; OBESITY; OVERWEIGHT; DISEASE; HEALTH
AB In the present study, we prospectively collected data from pre- to postmenopausal women with or without metabolic syndrome (MetS) and evaluated the impact of MetS on stress urinary incontinence (SUI) in women.
   The women divided into four equal groups: premenopausal with and without MetS; postmenopausal with and without MetS. There were 100 women in each group. We assessed the women for SUI at gynecologic position and we determined cough stress test. MetS was defined according to the criteria established in 2005 by the NCEP/ATP III.
   Mean age was 48.52 +/- A 8.16 in women with MetS and 48.81 +/- A 8.31 in women without MetS. SUI was found more often in both pre- and postmenopausal women with MetS (p = 0.001 and p < 0.001). It seems that postmenopausal women have more SUI than premenopausal women with MetS. We also evaluated the association between five components of MetS and SUI. Just, higher fasting glucose levels and waist circumference were significantly associated with SUI (p < 0.05).
   Our study shows that SUI is more prevalent in pre- and postmenopausal women with the MetS. SUI can be prevented with lifestyle changes for MetS. Multicenter studies with larger series and molecular studies are needed to determine the impact of the MetS on SUI.
C1 [Otunctemur, Alper; Dursun, Murat; Ozbek, Emin; Sahin, Suleyman; Besiroglu, Huseyin; Koklu, Ismail; Erkoc, Mustafa; Danis, Eyyup; Bozkurt, Muammer] Okmeydani Training & Res Hosp, Dept Urol, TR-34384 Istanbul, Turkey.
C3 Istanbul Okmeydani Training & Research Hospital
RP Otunctemur, A (corresponding author), Okmeydani Training & Res Hosp, Dept Urol, TR-34384 Istanbul, Turkey.
EM alperotunctemur@yahoo.com
RI Bozkurt, Muammer/AAT-5739-2021; Besiroglu, Huseyin/AAM-5318-2020; DANIŞ,
   EYYÜP/JXY-2445-2024; sahin, suleyman/ITU-0203-2023; dursun,
   murat/C-6318-2019; Erkoc, Mustafa/AAE-2641-2019
OI Otunctemur, Alper/0000-0002-0553-3012; Erkoc,
   Mustafa/0000-0003-0679-2873; Danis, Eyyup/0000-0002-5087-0595;
   Besiroglu, Huseyin/0000-0002-7459-584X
CR Abrams P., 2005, 3 INT CONSULTATION I, P1589
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NR 29
TC 17
Z9 17
U1 0
U2 5
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0301-1623
EI 1573-2584
J9 INT UROL NEPHROL
JI Int. Urol. Nephrol.
PD AUG
PY 2014
VL 46
IS 8
BP 1501
EP 1505
DI 10.1007/s11255-014-0680-7
PG 5
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA AN3YD
UT WOS:000340523800005
PM 24590564
DA 2025-06-11
ER

PT J
AU Zhao, L
   Feng, ZH
   Yang, XY
   Liu, JK
AF Zhao, Lin
   Feng, Zhihui
   Yang, Xiaoyong
   Liu, Jiankang
TI The regulatory roles of O-GlcNAcylation in mitochondrial
   homeostasis and metabolic syndrome
SO FREE RADICAL RESEARCH
LA English
DT Article; Proceedings Paper
CT 7th Biennial Meeting of Society-for-Free-Radical-Research-Asia
   (SFRR-Asia)
CY 2015
CL Chiang Mai, THAILAND
SP Soc Free Rad Res Asia
DE O-GlcNAcylation; mitochondria; oxidative stress; insulin resistance;
   nutrient sensing
ID LINKED GLCNAC TRANSFERASE; OXIDATIVE STRESS; SIGNALING PATHWAYS;
   INSULIN-RESISTANCE; CARDIAC MYOCYTES; HIGH GLUCOSE; PROTEINS; GICNAC;
   COMPLICATIONS; EXPRESSION
AB Nutrients excess is one of the leading causes of metabolic syndrome globally. Protein post-translational O-GlcNAc modification has been recognized as an essential nutrient sensor of the cell. Emerging studies suggest that O-GlcNAcylation lies at the core linking nutritional stress to insulin resistance. Mitochondria are the major site for ATP production in most eukaryotes. Mitochondrial dysfunction and oxidative stress have long been considered as an important mechanism underlying insulin resistance. The metabolic process is under the influence of environmental and nutritional factors, thus sensing and transducing nutritional signals sit at the pivot of metabolism control. For a long time little was known about O-GlcNAcylation within mitochondria since mitochondrial O-GlcNAcylation was regarded rare. Recent findings have demonstrated that O-GlcNAcylation is widely spread among mitochondrial proteins, and that mitochondrial function and oxidative stress both can be regulated by O-GlcNAcylation, particularly under diabetic circumstances.
C1 [Zhao, Lin; Feng, Zhihui; Liu, Jiankang] Xi An Jiao Tong Univ, Ctr Mitochondrial Biol & Med, Key Lab Biomed Informat Engn, Sch Life Sci & Technol,Minist Educ, Xian, Peoples R China.
   [Zhao, Lin; Feng, Zhihui; Liu, Jiankang] Xi An Jiao Tong Univ, Frontier Inst Sci & Technol, Xian, Peoples R China.
   [Yang, Xiaoyong] Yale Univ, Sch Med, Sect Comparat Med, New Haven, CT USA.
   [Yang, Xiaoyong] Yale Univ, Sch Med, Dept Cellular & Mol Physiol, New Haven, CT USA.
C3 Ministry of Education - China; Xi'an Jiaotong University; Xi'an Jiaotong
   University; Yale University; Yale University
RP Zhao, L (corresponding author), Xi An Jiao Tong Univ, Ctr Mitochondrial Biol & Med, Key Lab Biomed Informat Engn, Sch Life Sci & Technol,Minist Educ, Xian, Peoples R China.; Zhao, L (corresponding author), Xi An Jiao Tong Univ, Frontier Inst Sci & Technol, Xian, Peoples R China.; Zhao, L (corresponding author), Xi An Jiao Tong Univ, Ctr Mitochondrial Biol & Med, Xian 710049, Peoples R China.
EM zhaolin2015@xjtu.edu.cn
RI Liu, Jiankang/A-1610-2011; Zhao, Lin/AHD-2506-2022; Feng,
   Zhihui/E-7408-2011
OI Feng, Zhihui/0000-0002-2448-6565; , Lin Zhao/0000-0002-6056-8787
FU NIDDK NIH HHS [R01 DK089098, P30 DK034989, P01 DK057751] Funding Source:
   Medline
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NR 53
TC 35
Z9 39
U1 0
U2 13
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1071-5762
EI 1029-2470
J9 FREE RADICAL RES
JI Free Radic. Res.
PD OCT
PY 2016
VL 50
IS 10
BP 1080
EP 1088
DI 10.1080/10715762.2016.1239017
PG 9
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Biochemistry & Molecular Biology
GA EC2EH
UT WOS:000387922000005
PM 27646831
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Youn, JY
   Siu, KL
   Lob, HE
   Itani, H
   Harrison, DG
   Cai, H
AF Youn, Ji-Youn
   Siu, Kin Lung
   Lob, Heinrich E.
   Itani, Hana
   Harrison, David G.
   Cai, Hua
TI Role of Vascular Oxidative Stress in Obesity and Metabolic Syndrome
SO DIABETES
LA English
DT Article
ID NITRIC-OXIDE BIOAVAILABILITY; II-INDUCED HYPERTENSION; NADPH OXIDASES;
   ENDOTHELIAL DYSFUNCTION; CARDIOVASCULAR-DISEASE; MECHANISMS; LEPTIN;
   PATHOPHYSIOLOGY; ACTIVATION; INFARCTION
AB Obesity is associated with vascular diseases that are often attributed to vascular oxidative stress. We tested the hypothesis that vascular oxidative stress could induce obesity. We previously developed mice that overexpress p22phox in vascular smooth muscle, tg(sm/p22phox), which have increased vascular ROS production. At baseline, tg(sm/p22phox) mice have a modest increase in body weight. With high-fat feeding, tg(sm/p22phox) mice developed exaggerated obesity and increased fat mass. Body weight increased from 32.16 +/- 2.34 g to 43.03 +/- 1.44 g in tg(sm/p22phox) mice (vs. 30.81 +/- 0.71 g to 37.89 +/- 1.16 g in the WT mice). This was associated with development of glucose intolerance, reduced HDL cholesterol, and increased levels of leptin and MCP-1. Tg(sm/p22phox) mice displayed impaired spontaneous activity and increased mitochondrial ROS production and mitochondrial dysfunction in skeletal muscle. In mice with vascular smooth muscle-targeted deletion of p22phox (p22phox(loxp/loxp)/tg(smmhc/cre) mice), high-fat feeding did not induce weight gain or leptin resistance. These mice also had reduced T-cell infiltration of perivascular fat. In conclusion, these data indicate that vascular oxidative stress induces obesity and metabolic syndrome, accompanied by and likely due to exercise intolerance, vascular inflammation, and augmented adipogenesis. These data indicate that vascular ROS may play a causal role in the development of obesity and metabolic syndrome.
C1 [Youn, Ji-Youn; Siu, Kin Lung; Cai, Hua] Univ Calif Los Angeles, David Geffen Sch Med, Div Mol Med & Cardiol, Cardiovasc Res Lab,Dept Anesthesiol, Los Angeles, CA 90095 USA.
   [Youn, Ji-Youn; Siu, Kin Lung; Cai, Hua] Univ Calif Los Angeles, David Geffen Sch Med, Div Mol Med & Cardiol, Cardiovasc Res Lab,Dept Med, Los Angeles, CA 90095 USA.
   [Lob, Heinrich E.; Itani, Hana; Harrison, David G.] Vanderbilt Univ, Dept Med, Div Clin Pharmacol, Nashville, TN USA.
C3 University of California System; University of California Los Angeles;
   University of California Los Angeles Medical Center; David Geffen School
   of Medicine at UCLA; University of California System; University of
   California Los Angeles; University of California Los Angeles Medical
   Center; David Geffen School of Medicine at UCLA; Vanderbilt University
RP Cai, H (corresponding author), Univ Calif Los Angeles, David Geffen Sch Med, Div Mol Med & Cardiol, Cardiovasc Res Lab,Dept Anesthesiol, Los Angeles, CA 90095 USA.
EM david.g.harrison@vanderbilt.edu; hcai@mednet.ucla.edu
RI Harrison, David/ITT-6732-2023; Itani, Hana/ABE-8116-2021
FU National Heart, Lung, and Blood Institute (NHLBI) [HL-077440, HL-088975,
   HL-108701, HL-119968]; American Heart Association Established
   Investigator Award [12E-IA-8990025]
FX The authors' work was supported by National Heart, Lung, and Blood
   Institute (NHLBI) grants HL-077440 (to H. C.), HL-088975 (to H. C.),
   HL-108701 (to H. C. and D. G. H.), and HL-119968 (to H. C.) and American
   Heart Association Established Investigator Award 12E-IA-8990025 (to
   H.C.).
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NR 37
TC 110
Z9 122
U1 0
U2 8
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0012-1797
EI 1939-327X
J9 DIABETES
JI Diabetes
PD JUL
PY 2014
VL 63
IS 7
BP 2344
EP 2355
DI 10.2337/db13-0719
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA AJ7YO
UT WOS:000337918200024
PM 24550188
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Eleuterio-Silva, MA
   da Fonseca, LJS
   Velloso, EPP
   Guedes, GD
   Sampaio, WO
   da Silva, WF
   Mota-Gomes, MA
   Lima, LVD
   Santos, RAS
   Rabelo, LA
AF Eleuterio-Silva, Marcos Antonio
   Sa da Fonseca, Lucas Jose
   Velloso, Elizabeth P. P.
   Guedes, Glaucevane da Silva
   Sampaio, Walkyria O.
   da Silva, Weriton Ferreira
   Mota-Gomes, Marco Antonio
   da Silva Lima, Lucy V.
   Santos, Robson Augusto S.
   Rabelo, Luiza A.
TI SHORT-TERM CARDIOVASCULAR PHYSICAL PROGRAMME AMELIORATES ARTERIAL
   STIFFNESS AND DECREASES OXIDATIVE STRESS IN WOMEN WITH METABOLIC
   SYNDROME
SO JOURNAL OF REHABILITATION MEDICINE
LA English
DT Article
DE cardiometabolic diseases; physical training; vascular function;
   oxidative stress; functional exercise capacity
ID PULSE-WAVE VELOCITY; ENDOTHELIAL DYSFUNCTION; AUGMENTATION INDEX;
   SUPEROXIDE ANION; EXERCISE; PRESSURE; CAPACITY; PLASMA
AB Objective: To evaluate the impact of a short-term cardiovascular physical programme on the metabolic, anthropometric and oxidative stress parameters of women with metabolic syndrome.
   Methods: Thirty sedentary female patients, age range 30-60 years, were invited to participate in a 6-week cardiovascular physical programme. The training consisted of 60-min sessions of aerobic and strength exercises performed 3 times a week; a total of 18 sessions. Anthropometric data, functional exercise capacity, general biochemical profile, serum lipid peroxidation, superoxide dismutase and catalase activity in erythrocytes were evaluated according to standardized protocols. Peripheral vascular function was assessed using applanation tonometry. All assessments were performed before and after the training programme.
   Results: The physical programme proved effective in improving the distance covered in the 6-min walk test and in reducing arterial pressure levels, pulse pressure and the Augmentation Index, without modifying heart rate. The plasma thiobarbituric acid reactive substances levels, indicators of oxidative stress, were significantly decreased after the programme. Superoxide dismutase activity was increased in erythrocyte lysates, with no significant change in catalase activity. Waist circumference was significantly decreased compared with baseline.
   Conclusion: These findings indicate that short-term combined aerobic and strength training may represent an important non-pharmacological approach for treating individuals with metabolic syndrome.
C1 [Eleuterio-Silva, Marcos Antonio; Sa da Fonseca, Lucas Jose; Guedes, Glaucevane da Silva; da Silva, Weriton Ferreira; Rabelo, Luiza A.] Univ Fed Alagoas, Inst Ciencias Biol & Saude, Setor Fisiol & Farmacol, Lab Reatividade Cardiovasc, Maceio, Alagoas, Brazil.
   [Velloso, Elizabeth P. P.; Sampaio, Walkyria O.; Santos, Robson Augusto S.] Univ Fed Minas Gerais, Dept Fisiol & Biofis, Lab Hipertensao, Belo Horizonte, MG, Brazil.
   [Guedes, Glaucevane da Silva] Univ Fed Alagoas, Fac Nutr FANUT, Maceio, Alagoas, Brazil.
   [Mota-Gomes, Marco Antonio] Univ Estadual Ciencias Saude Alagoas UNCISAL, Fac Med, Maceio, Alagoas, Brazil.
   [da Silva Lima, Lucy V.] Univ Fed Alagoas, Fac Med FAMED, Maceio, Alagoas, Brazil.
   [Rabelo, Luiza A.] Max Delbruck Ctr Mol Med, Berlin, Germany.
   [Eleuterio-Silva, Marcos Antonio; Sa da Fonseca, Lucas Jose; Velloso, Elizabeth P. P.; Guedes, Glaucevane da Silva; Sampaio, Walkyria O.; da Silva, Weriton Ferreira; Santos, Robson Augusto S.; Rabelo, Luiza A.] Inst Nacl Ciencia & Tecnol NanoBiofarmaceut N BIO, Belo Horizonte, MG, Brazil.
   [Eleuterio-Silva, Marcos Antonio] Univ Fed Campina Grande, Unidade Acad Ciencias Vida, Lab Fisiol Imunol & Farmacol, Cajazeiras, Paraiba, Brazil.
C3 Universidade Federal de Alagoas; Universidade Federal de Minas Gerais;
   Universidade Federal de Alagoas; Universidade Estadual de Ciencias da
   Saude de Alagoas; Universidade Federal de Alagoas; Helmholtz
   Association; Max Delbruck Center for Molecular Medicine; Universidade
   Federal de Campina Grande
RP Rabelo, LA (corresponding author), Pca Afranio Jorge S-N, BR-57010020 Maceio, Alagoas, Brazil.
EM luizaa.rabelo@gmail.com
RI Rabêlo, Luiza/S-4050-2019; Santos, Robson/C-9336-2011
OI Santos, Robson/0000-0001-8738-5852; Eleuterio da Silva, Marcos
   Antonio/0000-0003-1952-7905
FU Brazil's Ministry of Health/CNPq/SESAU-AL/FAPEAL [PPSUS-2006
   PROJ_893_11388592]; PROCAD-NF/CAPES [PROCAD-NF 2450/2008]
FX This work was supported by grants from Brazil's Ministry of
   Health/CNPq/SESAU-AL/FAPEAL (PPSUS-2006 PROJ_893_11388592) and
   PROCAD-NF/CAPES (PROCAD-NF 2450/2008).
CR [Anonymous], J REHABIL MED, P45
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NR 36
TC 16
Z9 20
U1 0
U2 10
PU FOUNDATION REHABILITATION INFORMATION
PI UPPSALA
PA TRADGARDSGATAN 14, UPPSALA, SE-753 09, SWEDEN
SN 1650-1977
EI 1651-2081
J9 J REHABIL MED
JI J. Rehabil. Med.
PD JUN
PY 2013
VL 45
IS 6
BP 572
EP 579
DI 10.2340/16501977-1148
PG 8
WC Rehabilitation; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Rehabilitation; Sport Sciences
GA 172UI
UT WOS:000321030000010
PM 23708239
OA gold
DA 2025-06-11
ER

PT J
AU Macavei, B
   Baban, A
   Dumitrascu, DL
AF Macavei, B.
   Baban, A.
   Dumitrascu, D. L.
TI Psychological factors associated with NAFLD/NASH: a systematic review
SO EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
LA English
DT Review
DE Nonalcoholic fatty liver disease (NAFLD); Nonalcoholic steatohepatitis
   (NASH); Cognitive factors; Behavioral factors; Emotional factors
ID NONALCOHOLIC FATTY LIVER; CHRONIC HEPATITIS-C; METABOLIC SYNDROME;
   RISK-FACTORS; HISTOLOGICAL SEVERITY; MAJOR DEPRESSION; DISEASE NAFLD;
   DECREASED PREVALENCE; ALCOHOL-CONSUMPTION; PHYSICAL-ACTIVITY
AB OBJECTIVE: Nonalcoholic fatty liver disease (NAFLD) represents one of the most common chronic liver diseases worldwide. So far, the pathogenesis of NAFLD and its more severe variant nonalcoholic steatohepatitis (NASH) is yet unclear, with many mechanisms being proposed as possible causes. This article aims to review the psychological factors associated with NAFLD/NASH.
   MATERIALS AND METHODS: Three main categories of factors have been investigated: emotional, cognitive and behavioral. Five electronic databases were searched, limited to studies published in the English language, during the period 2005-2015: PubMed, Thomson ISI - Web of Science, Scopus, ProQuest, and ScienceDirect.
   RESULTS: Results indicated the most relevant emotional factors to be depression and anxiety. The areas of investigation for cognitive functioning concern those contents and processes related to the ability to initiate and maintain lifestyle changes. The most important behavioral factors identified are physical activity, nutrition/ food intake and substance consumption: coffee, alcohol, cigarettes.
   CONCLUSIONS: Some of the factors identified act as protective factors, other as vulnerability factors. NAFLD/NASH may be considered a cognitive-behavioral disease, the most effective management being lifestyle changes, with emphasis on diet and exercise.
C1 [Macavei, B.; Baban, A.] Univ Babes Bolyai, Dept Psychol, Cluj Napoca, Romania.
   [Dumitrascu, D. L.] Univ Med & Pharm Iuliu Hatieganu, Med Clin 2, Cluj Napoca, Romania.
C3 Babes Bolyai University from Cluj; Iuliu Hatieganu University of
   Medicine & Pharmacy
RP Baban, A (corresponding author), Univ Babes Bolyai, Dept Psychol, Cluj Napoca, Romania.
EM adrianababan@gmail.com
RI Dumitrascu, Dan/C-4618-2011
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NR 60
TC 34
Z9 38
U1 0
U2 21
PU VERDUCI PUBLISHER
PI ROME
PA VIA GREGORIO VII, ROME, 186-00165, ITALY
SN 1128-3602
J9 EUR REV MED PHARMACO
JI Eur. Rev. Med. Pharmacol. Sci.
PD DEC
PY 2016
VL 20
IS 24
BP 5081
EP 5097
PG 17
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA EK1NH
UT WOS:000393691900009
PM 28051263
DA 2025-06-11
ER

PT J
AU Nasoohi, S
   Parveen, K
   Ishrat, T
AF Nasoohi, Sanaz
   Parveen, Kehkashan
   Ishrat, Tauheed
TI Metabolic Syndrome, Brain Insulin Resistance, and Alzheimer's Disease:
   Thioredoxin Interacting Protein (TXNIP) and Inflammasome as Core
   Amplifiers
SO JOURNAL OF ALZHEIMERS DISEASE
LA English
DT Review
DE Alzheimer's disease; brain insulin resistance; inflammasomes; metabolic
   syndrome; oxidative stress; thioredoxin-interacting protein (TXNIP);
   type 3 diabetes
ID FREE FATTY-ACID; NICOTINIC ACETYLCHOLINE-RECEPTOR; ADVANCED GLYCATION
   ENDPRODUCTS; VASCULAR RISK-FACTORS; BETA/NF-KAPPA-B; NLRP3 INFLAMMASOME;
   OXIDATIVE STRESS; COGNITIVE IMPAIRMENT; DIABETES-MELLITUS; LATE-LIFE
AB Empirical evidence indicates a strong association between insulin resistance and pathological alterations related to Alzheimer's disease (AD) in different cerebral regions. While cerebral insulin resistance is not essentially parallel with systemic metabolic derangements, type 2 diabetes mellitus (T2DM) has been established as a risk factor for AD. The circulating "toxic metabolites" emerging in metabolic syndrome may engage several biochemical pathways to promote oxidative stress and neuroinflammation leading to impair insulin function in the brain or "type 3 diabetes". Thioredoxin-interacting protein (TXNIP) as an intracellular amplifier of oxidative stress and inflammasome activation may presumably mediate central insulin resistance. Emerging data including those from our recent studies has demonstrated a sharp TXNIP upregulation in stroke, aging and AD and well underlining the significance of this hypothesis. With the main interest to illustrate TXNIP place in type 3 diabetes, the present review primarily briefs the potential mechanisms contributing to cerebral insulin resistance in a metabolically deranged environment. Then with a particular focus on plausible TXNIP functions to drive and associate with AD pathology, we present the most recent evidence supporting TXNIP as a promising therapeutic target in AD as an age-associated dementia.
C1 [Nasoohi, Sanaz; Ishrat, Tauheed] Univ Tennessee, Dept Anat & Neurobiol, Hlth Sci Ctr, Memphis, TN 38163 USA.
   [Nasoohi, Sanaz] Shahid Beheshti Univ Med Sci, Neurosci Res Ctr, Tehran, Iran.
   [Parveen, Kehkashan] Hamdard Univ, Dept Biochem, New Delhi, India.
   [Ishrat, Tauheed] Univ Tennessee, Neurosci Inst, Hlth Sci Ctr, Memphis, TN 38163 USA.
C3 University of Tennessee System; University of Tennessee Health Science
   Center; Shahid Beheshti University Medical Sciences; Jamia Hamdard
   University; University of Tennessee System; University of Tennessee
   Health Science Center
RP Ishrat, T (corresponding author), Univ Tennessee, Hlth Sci Ctr, Coll Med, Dept Anat & Neurobiol, 855 Monroe Ave,Wittenborg Bldg,Room 231, Memphis, TN 38163 USA.
EM tishrat@uthsc.edu
RI Parveen, Kehkashan/GQH-9443-2022
OI Nasoohi, Sanaz/0000-0002-8499-1256
FU National Institute of Health [R01-NS097800]
FX This work was supported by the National Institute of Health grant
   [R01-NS097800 (TI)].
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NR 280
TC 30
Z9 30
U1 2
U2 19
PU IOS PRESS
PI AMSTERDAM
PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS
SN 1387-2877
EI 1875-8908
J9 J ALZHEIMERS DIS
JI J. Alzheimers Dis.
PY 2018
VL 66
IS 3
BP 857
EP 885
DI 10.3233/JAD-180735
PG 29
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA HB6ZZ
UT WOS:000451225400001
PM 30372683
DA 2025-06-11
ER

PT J
AU Yang, M
   Jiang, ZH
   Li, CG
   Zhu, YJ
   Li, Z
   Tang, YZ
   Ni, CL
AF Yang, Min
   Jiang, Zhen-huan
   Li, Chen-guang
   Zhu, Yan-juan
   Li, Zhu
   Tang, Yun-zhao
   Ni, Chang-lin
TI Apigenin prevents metabolic syndrome in high-fructose diet-fed mice by
   Keap1-Nrf2 pathway
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Article
DE Apigenin; Metabolic syndrome; Keap1-Nrf2
ID OXIDATIVE STRESS; INSULIN-RESISTANCE; NRF2 ACTIVATION; SERUM-LIPIDS;
   PC12 CELLS; MECHANISMS; ENZYMES; EXPRESSION; PROTECTION; INDUCTION
AB Chronic dietary high fructose leads to various kinds of undesirable metabolic effects. Apigenin, a naturally occurring plant flavone, is plentiful in fruits and vegetables. The aim of this study was to identify the protective effects of apigenin on metabolic syndrome and elucidate potential underlying mechanisms. The animal model was established by 4-weeks high fructose feeding. Insulin resistance was estimated by oral glucose tolerance test and homeostasis model assessment-insulin resistance index. Liver function was evaluated by serum AST and ALT, hepatic histopathological alternation, and lipid accumulation in the liver. The alterations of lipid profile was evaluated by TG, TC, LDL-C and HDL-C levels in serum. Administration of apigenin exerted beneficial effects through improving insulin resistance, alleviating liver injury, and inhibiting the alterations of lipid profile in high fructose-fed mice. In addition, apigenin potently facilitated the accumulation of Nrf2 nuclear translocation and accompanied by increasing HO-1 and NQO1 protein expressions, which are responsible for attenuating oxidative stress. Molecular docking results demonstrated that potential interaction of apigenin with the Nrf2-binding site in the Keap1 protein. In summary, we demonstrated that apigenin prevented high fructose-induced metabolic syndrome probably by inhibiting binding of Keap1 to Nrf2, and thus Nrf2 nuclear translocation, subsequently resulting in increased the expressions of anti-oxidative genes including HO-1 and NQO1.
C1 [Yang, Min] Tianjin Med Univ, Key Lab Hormones & Dev, Tianjin Key Lab Metab Dis, Minist Hlth,Tianjin Metab Dis Hosp, Tianjin 300070, Peoples R China.
   Tianjin Med Univ, Tianjin Inst Endocrinol, Tianjin 300070, Peoples R China.
C3 Tianjin Medical University; Tianjin Medical University
RP Yang, M (corresponding author), Tianjin Med Univ, Key Lab Hormones & Dev, Tianjin Key Lab Metab Dis, Minist Hlth,Tianjin Metab Dis Hosp, Tianjin 300070, Peoples R China.
EM sanyoumu007@163.com
RI JIANG, ZHENHUAN/KCD-7096-2024
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Z9 75
U1 2
U2 42
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD SEP
PY 2018
VL 105
BP 1283
EP 1290
DI 10.1016/j.biopha.2018.06.108
PG 8
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA GM6UT
UT WOS:000438312600147
PM 30021365
DA 2025-06-11
ER

PT J
AU Khanna, S
   Walia, S
   Kondepudi, KK
   Shukla, G
AF Khanna, Sakshi
   Walia, Sanisha
   Kondepudi, Kanthi Kiran
   Shukla, Geeta
TI Administration of indigenous probiotics modulate high-fat diet-induced
   metabolic syndrome in Sprague Dawley rats
SO ANTONIE VAN LEEUWENHOEK INTERNATIONAL JOURNAL OF GENERAL AND MOLECULAR
   MICROBIOLOGY
LA English
DT Article
DE Dyslipidemia; High fat diet; Metabolic syndrome; Obesity; Probiotics
ID OXIDATIVE STRESS; GUT MICROBIOTA; LACTOBACILLUS-ACIDOPHILUS; OBESITY;
   ENZYMES; CASEI
AB Modulation of the gut microbiota by probiotics, is emerging as a promising approach for the management of metabolic diseases but due to their species and strain specific response, isolation of new probiotic strains is gaining importance. The present study was designed to assess the effect of isolated and well characterised indigenous probiotics,Lactobacillus pentosusGSSK2,Lactobacillus fermentumPUM andLactobacillus plantarumGS26A in high fat diet (HFD) induced metabolic syndrome. It was observed that though supplementation of all three probiotics for 12 weeks to Sprague Dawley rats fed with HFD, ameliorated the anthropometric parameters, butL. pentosusGSSK2 showed maximum reduction in weight gain while maximum decrease in abdominal circumference, Lee's index, BMI and visceral fat deposition was observed inL. plantarumGS26A compared with HFD animals. Further, administration ofL. plantarumGS26A to HFD animals led to significant increase in lactic acid bacteria count and lipid excretion in feces followed byL. pentosusGSSK2 andL. fermentumPUM compared with counter controls. Additionally, bothL. pentosusGSSK2 andL. plantarumGS26A exhibited improved glucose tolerance, liver biomarkers, alleviated oxidative stress and restored the histoarchitechture of adipose tissue, colon and liver compared with HFD animals. The study highlights the prophylactic potential of isolated probiotics in experimental metabolic syndrome model and revealed that amongst all three probiotics,L. pentosusGSSK2 andL. plantarumGS26A were equally effective and more promising thanL. fermentumPUM in improving metabolic dysfunctions and may be employed as functional foods but needs to be correlated clinically.
C1 [Khanna, Sakshi; Walia, Sanisha; Shukla, Geeta] Panjab Univ, Dept Microbiol, Basic Med Sci, Block A,South Campus, Chandigarh 160014, India.
   [Kondepudi, Kanthi Kiran] Natl Agri Food Biotechnol Inst NABI, Div Biotechnol, Healthy Gut Res Grp Food & Nutr, Sas Nagar 140306, Punjab, India.
C3 Panjab University; Department of Biotechnology (DBT) India; National
   Agri Food Biotechnology Institute (NABI)
RP Shukla, G (corresponding author), Panjab Univ, Dept Microbiol, Basic Med Sci, Block A,South Campus, Chandigarh 160014, India.
EM geeta_shukla@pu.ac.in
RI Kondepudi, Kanthi/P-8336-2014
OI Kondepudi, Kanthi Kiran/0000-0001-8036-7555
FU Department of Microbiology, Panjab University, Chandigarh
FX The financial support provided by the Department of Microbiology, Panjab
   University, Chandigarh is highly acknowledged.
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NR 42
TC 26
Z9 29
U1 2
U2 18
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0003-6072
EI 1572-9699
J9 ANTON LEEUW INT J G
JI Antonie Van Leeuwenhoek
PD SEP
PY 2020
VL 113
IS 9
BP 1345
EP 1359
DI 10.1007/s10482-020-01445-y
EA JUL 2020
PG 15
WC Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Microbiology
GA MW9UJ
UT WOS:000545892800001
PM 32632629
DA 2025-06-11
ER

PT J
AU Cai, DH
   Xia, MM
   Chen, XH
   Yagi, K
   Xu, L
   Wang, BY
   Wang, YY
   Zhou, YJ
   Liu, JH
AF Cai, Dihui
   Xia, Mengming
   Chen, Xuhui
   Yagi, Kunimasa
   Xu, Liang
   Wang, Bingyu
   Wang, Yanyi
   Zhou, Yujie
   Liu, Jianhui
TI Heartache and Heartbreak: An Observational and Mendelian Randomization
   Study
SO GLOBAL HEART
LA English
DT Article
DE Mendelian randomization; depression; cardiovascular diseases
ID DEPRESSION INCREASES; GLOBAL BURDEN; RISK; INSTRUMENTS; METAANALYSIS;
   ASSOCIATION; SYMPTOMS; DISEASES; LINK
AB Background: Depression has a significant effect on cardiovascular disease (CVD), but uncertainties persist regarding which modifiable risk factors mediate the causal effects. We aim to determine whether depression is causally linked to CVD and which modifiable risk factors play potential mediating roles. Methods: We used a two -sample Mendelian randomization (MR) approach and NHANES 2007-2018 data to estimate the effects of depression on various CVD cases and investigated 28 potential mediators of the association between depression and CVD. Results: The results of our MR analysis indicated that genetically determined depression was associated with increased risk of several CVD, including coronary heart disease (odds ratio (OR) = 1.14; 95% confidence interval (CI): 1.05,1.22), myocardial infarction (OR = 1.19; 95% CI, 1.09,1.31), atrial fibrillation (OR = 1.14; 95% CI, 1.06,1.22), and stroke (OR = 1.13; 95% CI, 1.05,1.22). However, there was no causal association between depression and heart failure. Four out of 28 cardiometabolic risk factors, including hyperlipidemia, hypertension, diabetes, and prescription opioid use, were identified as mediators of the association between depression and various CVDs. Observational association analyses from NHANES data yielded consistent results. Conclusion: Our findings demonstrated that depression has a causal detrimental effect on various CVDs. Four causal mediators (hyperlipidemia, hypertension, diabetes, and prescription opioid use) were screened to explain the causal effect. Implementing targeted management strategies for these risk factors may be warranted to mitigate the public health burden of CVD among individuals with depression.
C1 [Cai, Dihui; Wang, Bingyu; Liu, Jianhui] Lihuili Hosp, Ningbo Med Ctr, Dept Cardiol, 57 Xingning Rd, Ningbo, Zhejiang, Peoples R China.
   [Xia, Mengming; Chen, Xuhui] Lihuili Hosp, Ningbo Med Ctr, Dept Pharm, Ningbo, Zhejiang, Peoples R China.
   [Yagi, Kunimasa] Kanazawa Med Univ, Sch Med, Kanazawa, Ishikawa, Japan.
   [Xu, Liang] Wenzhou Med Univ, Sch Lab Med & Life Sci, Wenzhou, Zhejiang, Peoples R China.
   [Wang, Yanyi; Zhou, Yujie] Ningbo Univ, Hlth Sci Ctr, Ningbo, Zhejiang, Peoples R China.
C3 Kanazawa Medical University; Wenzhou Medical University; Ningbo
   University
RP Liu, JH (corresponding author), Lihuili Hosp, Ningbo Med Ctr, Dept Cardiol, 57 Xingning Rd, Ningbo, Zhejiang, Peoples R China.
EM circulation_liu@163.com
RI Zhou, Yujie/AAE-8906-2021; Yagi, Kunimasa/AAA-8666-2021; cai,
   dihui/JLM-1749-2023
FU Natural Science Foundation of Ningbo Municipality [2022J254]
FX This work was supported by the Natural Science Foundation of Ningbo
   Municipality (2022J254) .
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NR 58
TC 2
Z9 2
U1 2
U2 7
PU UBIQUITY PRESS LTD
PI LONDON
PA Unit 3N, 6 Osborn Street, LONDON, E1 6TD, ENGLAND
SN 2211-8160
EI 2211-8179
J9 GLOB HEART
JI Glob. Heart
PY 2024
VL 19
IS 1
AR 19
DI 10.5334/gh.1302
PG 14
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA RU5L8
UT WOS:001230185900021
PM 38371655
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Dakanalis, A
   Riva, G
   Serino, S
   Colmegna, F
   Clerici, M
AF Dakanalis, Antonios
   Riva, Giuseppe
   Serino, Silvia
   Colmegna, Fabrizia
   Clerici, Massimo
TI Classifying Adults with Binge Eating Disorder Based on Severity Levels
SO EUROPEAN EATING DISORDERS REVIEW
LA English
DT Article
DE binge eating; severity; psychopathology; metabolic syndrome
ID BODY CHECKING QUESTIONNAIRE; COGNITIVE-BEHAVIOR THERAPY; METABOLIC
   SYNDROME; PSYCHOMETRIC PROPERTIES; NEGATIVE AFFECT; PSYCHOSOCIAL
   IMPAIRMENT; INTERPERSONAL PROBLEMS; SCREENING SCALES; AXIS-II;
   PREDICTORS
AB The clinical utility of the severity criterion for binge eating disorder (BED), introduced in the DSM-5 as a means of addressing heterogeneity and variability in the severity of this disorder, was evaluated in 189 treatment-seeking adults with (DSM-5) BED. Participants classified with mild, moderate, severe and extreme severity of BED, based on their weekly frequency of binge eating episodes, differed significantly from each other in body mass index (BMI), eating disorder features, putative factors involved in the maintenance process of the disorder, comorbid mood, anxiety and personality disorders, psychological distress, social maladjustment and illness-specific functional impairment (medium-to-large effect sizes). They were also statistically distinguishable in metabolic syndrome prevalence, even after adjusting for BMI (large effect size), suggesting the possibility of non-BMI-mediated mechanisms. The implications of the findings, providing support for the utility of the binge frequency as a severity criterion for BED, and directions for future research are outlined. Copyright (C) 2017 John Wiley & Sons, Ltd and Eating Disorders Association
C1 [Dakanalis, Antonios; Clerici, Massimo] Univ Milano Bicocca, Milan, Italy.
   [Dakanalis, Antonios] Univ Pavia, Pavia, Italy.
   [Riva, Giuseppe] Ist Auxol Italiano, Milan, Italy.
   [Riva, Giuseppe; Serino, Silvia] Catholic Univ, Milan, Italy.
   [Colmegna, Fabrizia; Clerici, Massimo] San Gerardo Hosp, Monza, Italy.
C3 University of Milano-Bicocca; University of Pavia; IRCCS Istituto
   Auxologico Italiano; Catholic University of the Sacred Heart; San
   Gerardo Hospital
RP Dakanalis, A (corresponding author), Univ Milano Bicocca, Dept Med & Surg, Via Cadore 48, I-20900 Monza, Italy.
EM antonios.dakanalis@unimib.it
RI Serino, Silvia/AAM-5297-2020; Clerici, Massimo/U-3074-2019; Dakanalis
   Antonios Ntakanales, MD, MSc, PsyD, PhD, FNASc, Antonios/I-5105-2013;
   Riva, Giuseppe/C-5917-2008
OI Dakanalis Antonios Ntakanales, MD, MSc, PsyD, PhD, FNASc,
   Antonios/0000-0002-2328-3862; Riva, Giuseppe/0000-0003-3657-106X;
   Clerici, Massimo/0000-0001-8769-6474
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NR 80
TC 17
Z9 20
U1 3
U2 13
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1072-4133
EI 1099-0968
J9 EUR EAT DISORD REV
JI Eur. Eat. Disord. Rev.
PD JUL
PY 2017
VL 25
IS 4
BP 268
EP 274
DI 10.1002/erv.2518
PG 7
WC Psychology, Clinical; Psychiatry
WE Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA FA1SO
UT WOS:000405220200003
PM 28425618
DA 2025-06-11
ER

PT J
AU van den Heuvel, LL
   Stalder, T
   du Plessis, S
   Suliman, S
   Kirschbaum, C
   Seedat, S
AF van den Heuvel, Leigh Luella
   Stalder, Tobias
   du Plessis, Stefan
   Suliman, Sharain
   Kirschbaum, Clemens
   Seedat, Soraya
TI Hair cortisol levels in posttraumatic stress disorder and metabolic
   syndrome
SO STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS
LA English
DT Article
DE Posttraumatic stress disorder; hair cortisol concentrations; metabolic
   syndrome; trauma; cardiovascular disease; hypothalamic-pituitary-adrenal
   (HPA) axis
ID INDIVIDUALS; VALIDATION; ADOLESCENTS; BIOMARKER; SYMPTOMS; OBESITY;
   HUMANS; PEOPLE
AB Individuals with post-traumatic stress disorder (PTSD) evidence increased rates of metabolic syndrome (MetS), and both PTSD and MetS are associated with alterations in hypothalamic-pituitary-adrenal (HPA) axis function. Few investigations have examined the possible role of HPA-axis dysfunction in the co-occurrence of PTSD and MetS. In a case-control study, we aimed to determine whether hair cortisol concentrations (HCC) were associated with (i) PTSD caseness and severity and (ii) PTSD and MetS co-occurrence. We used the Clinician-Administered PTSD Scale for DSM-5 (CAPS-5) to determine PTSD diagnoses and severity scores in 216 females of mixed ancestry aged between 20 and 79 years (M = 43.8, SD =13.3). Hair samples, representing a three-month retrospective window of cortisol levels, were obtained and analyzed utilizing liquid chromatography-tandem mass spectrometry. We constructed multivariate linear regression models to evaluate whether PTSD diagnosis, PTSD severity, and MetS comorbidity were associated with HCC, controlling for potential confounders. HCC were significantly higher (adj beta = 0.154, p = .033; Cohen's d = 0.44) in PTSD patients (n = 110) than trauma-exposed controls (n = 106) and CAPS severity scores (adj beta = 0.207, p = .005) were significantly associated with HCC. MetS was not associated with HCC and there were no significant interactions between PTSD and MetS on HCC. This study provides evidence of a chronically dysregulated neuroendocrine mediated stress response in PTSD, with a clear dose-response relationship. HCC do not, however, appear to have specificity for the comorbidity of PTSD and MetS in this sample.LAY SUMMARY We found that levels of the stress hormone, cortisol, measured in hair samples were significantly higher in South African women with post-traumatic stress disorder (PTSD) than in women who had also experienced trauma but did not have PTSD. Hair cortisol levels were, however, not associated with metabolic syndrome, a cluster of risk factors for heart disease, in the women studied. We thus show that South African women with PTSD have elevated long-term stress hormone levels and that this effect is related to PTSD and not solely due to trauma exposure.
C1 [van den Heuvel, Leigh Luella; du Plessis, Stefan; Suliman, Sharain; Seedat, Soraya] Stellenbosch Univ, Fac Med & Hlth Sci, Dept Psychiat, Clin Bldg,Francie van Zijl Dr,POB 241, ZA-7505 Cape Town, South Africa.
   [Stalder, Tobias] Univ Siegen, Dept Clin Psychol, Siegen, Germany.
   [Kirschbaum, Clemens] Tech Univ Dresden, Dept Biol Psychol, Dresden, Germany.
C3 Stellenbosch University; Universitat Siegen; Technische Universitat
   Dresden
RP van den Heuvel, LL (corresponding author), Stellenbosch Univ, Fac Med & Hlth Sci, Dept Psychiat, Clin Bldg,Francie van Zijl Dr,POB 241, ZA-7505 Cape Town, South Africa.
EM llvdh@sun.ac.za
RI Suliman, Sharain/ABC-8843-2020; Kirschbaum, Clemens/AAB-1752-2020; du
   Plessis, Stefan/AFO-8572-2022; van den Heuvel, Leigh/AGV-5481-2022
OI Suliman, Sharain/0000-0001-5510-3128; Seedat,
   Soraya/0000-0002-5118-786X; du Plessis, Stefan/0000-0001-9750-5731;
   Stalder, Tobias/0000-0001-7558-1274; , Clemens/0000-0003-3707-4444; van
   den Heuvel, Leigh/0000-0003-3884-4754
FU South African Medical Research Council; South African National Treasury
   under its Economic Competitiveness and Support Package
   [MRC-RFA-IFSP-01-2013/SHARED ROOTS]; South African Medical Research
   Council through its Division of Research Capacity Development; South
   African National Treasury; South African Research Chairs Initiative in
   PTSD - Department of Science and Technology; National Research
   Foundation; SAMRC Self-Initiated Research Grant; Stellenbosch University
   FMHS; German Research Foundation [KI-537/37-1, STA 1213/6-1]
FX This work was supported by the South African Medical Research Council
   for the "Shared Roots" Flagship Project through funding received from
   the South African National Treasury under its Economic Competitiveness
   and Support Package [grant number MRC-RFA-IFSP-01-2013/SHARED ROOTS].
   Its contents are solely the responsibility of the authors and do not
   necessarily represent the official views of the South African Medical
   Research Council. The work by Leigh van den Heuvel reported herein was
   made possible through funding by the South African Medical Research
   Council through its Division of Research Capacity Development under the
   SAMRC CLINICIAN RESEARCHER (MD PHD) SCHOLARSHIP PROGRAM from funding
   received from the South African National Treasury. The content hereof is
   the sole responsibility of the authors and do not necessarily represent
   the official views of the SAMRC or the funders. Soraya Seedat and
   Sharain Suliman are supported by the South African Research Chairs
   Initiative in PTSD funded by the Department of Science and Technology
   and the National Research Foundation. Sharain Suliman is also supported
   by a SAMRC Self-Initiated Research Grant and The Stellenbosch University
   FMHS. The research reported in this publication was supported by the
   German Research Foundation [grant number KI-537/37-1], [grant number STA
   1213/6-1].
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NR 47
TC 31
Z9 33
U1 0
U2 6
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1025-3890
EI 1607-8888
J9 STRESS
JI Stress
PD SEP 2
PY 2020
VL 23
IS 5
BP 577
EP 589
DI 10.1080/10253890.2020.1724949
EA FEB 2020
PG 13
WC Behavioral Sciences; Endocrinology & Metabolism; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Behavioral Sciences; Endocrinology & Metabolism; Neurosciences &
   Neurology
GA NL8TM
UT WOS:000514726300001
PM 32008379
DA 2025-06-11
ER

PT J
AU Shi, Z
   Tuomilehto, J
   Kronfeld-Schor, N
   Alberti, GK
   Stern, N
   El-Osta, A
   Bilu, C
   Einat, H
   Zimmet, P
AF Shi, Z.
   Tuomilehto, J.
   Kronfeld-Schor, N.
   Alberti, G. K.
   Stern, N.
   El-Osta, A.
   Bilu, C.
   Einat, H.
   Zimmet, P.
TI The circadian syndrome predicts cardiovascular disease better than
   metabolic syndrome in Chinese adults
SO JOURNAL OF INTERNAL MEDICINE
LA English
DT Article
DE adults; cardiovascular disease; Chinese; circadian syndrome; metabolic
   syndrome
ID PREVALENCE; HEALTH; SLEEP; CONSEQUENCES; DEPRESSION; VALIDITY; GENETICS;
   COHORT; RISK; WELL
AB Background To compare the predictive value of the circadian syndrome (CircS) and Metabolic syndrome (MetS) for cardiovascular disease.
   Method We used the data of 9360 Chinese adults aged >= 40 years from the 2011 China Health and Retirement Longitudinal Study (CHARLS). Of the participants, 8253 people were followed in the 2015 survey. MetS was defined using the harmonized criteria. CircS was based on the components of the International Diabetes Federation (IDF) MetS plus short sleep and depression. The cut-off for CircS was set as >= 4. Multivariable logistic regression analysis was used to examine the associations.
   Results The prevalence of CircS and MetS was 39.0% and 44.7%. Both MetS and CircS were directly associated with prevalent CVD. The odds ratios for prevalent CVD comparing CircS with MetS, respectively, were 2.83 (95%CI 2.33-3.43) and 2.34 (1.93-2.83) in men, and 2.33 (1.98-2.73) and 1.79 (1.53-2.10) in women. Similar associations were found for incident CVD. The five-year incidence of CVD was 15.1% in CircS and 14.0% in MetS. The number of CircS components has a better predictive power for both prevalent and incident CVD than those of Mets components as indicated by the area under the ROC (AUC). AUC values for CVD in 2011 were higher for CircS than MetS in both men (0.659 (95%CI 0.634-0.684) vs 0.635 (95%CI 0.610-0.661)) and women (0.652 (95%CI 0.632-0.672) vs 0.619 (95%CI 0.599-0.640)).
   Conclusion The circadian syndrome is a strong and better predictor for CVD than the metabolic syndrome in Chinese adults.
C1 [Shi, Z.] Qatar Univ, Coll Hlth Sci, Human Nutr Dept, QU Hlth, POB 2713, Doha, Qatar.
   [Tuomilehto, J.] Univ Helsinki, Dept Publ Hlth, Helsinki, Finland.
   [Kronfeld-Schor, N.; Bilu, C.] Tel Aviv Univ, Sch Zool, Tel Aviv, Israel.
   [Alberti, G. K.] Imperial Coll London, Dept Endocrinol & Metab, London, England.
   [Stern, N.; Zimmet, P.] Tel Aviv Med Ctr & Sch Med, Sagol Epigenet Ctr, Tel Aviv, Israel.
   [El-Osta, A.; Zimmet, P.] Monash Univ, Cent Clin Sch, Dept Diabet, Melbourne, Vic, Australia.
   [El-Osta, A.] Chinese Univ Hong Kong, Hong Kong, Peoples R China.
   [Einat, H.] Tel Aviv Yaffo Acad Coll, Sch Behav Sci, Tel Aviv, Israel.
C3 Qatar University; University of Helsinki; Tel Aviv University; Imperial
   College London; Tel Aviv University; Sackler Faculty of Medicine; Monash
   University; Chinese University of Hong Kong
RP Shi, Z (corresponding author), Qatar Univ, Coll Hlth Sci, Human Nutr Dept, QU Hlth, POB 2713, Doha, Qatar.
EM zumin@qu.edu.qa
RI Kronfeld-Schor, Noga/AAU-3792-2020; Shi, Zumin/A-1093-2009; tuomilehto,
   jaakko/E-6504-2011; Zimmet, Paul/H-7635-2013
OI El-Osta, Assam/0000-0003-2969-9137; Shi, Zumin/0000-0002-3099-3299;
   Kronfeld-Schor, Noga/0000-0002-5224-3341
FU Qatar National Library
FX Open Access funding was provided by the Qatar National Library.
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NR 28
TC 59
Z9 60
U1 4
U2 39
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0954-6820
EI 1365-2796
J9 J INTERN MED
JI J. Intern. Med.
PD JUN
PY 2021
VL 289
IS 6
BP 851
EP 860
DI 10.1111/joim.13204
EA DEC 2020
PG 10
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA SG8CZ
UT WOS:000599971100001
PM 33340184
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Braga, RT
   D'Oliveira, A
AF Braga Filho, Romario Teixeira
   D'Oliveira, Argemiro, Jr.
TI The Prevalence of Metabolic Syndrome Among Soldiers of the Military
   Police of Bahia State, Brazil
SO AMERICAN JOURNAL OF MENS HEALTH
LA English
DT Article
DE men's health; cardiovascular disease; metabolic syndrome; military
   police; Brazil
ID RISK-FACTORS; POPULATION
AB The mortality rate of men is generally higher than that of women, irrespective of the age group. Currently, a key concern for health care professionals is the prevalence of risk factors associated with cardiovascular disease and metabolic syndrome. This study aimed at assessing the prevalence of individual risk factors for cardiovascular disease as well as the prevalence of metabolic syndrome among men serving in the Military Police Corps of the state of Bahia, Brazil. This service employs mostly men, and they are known to experience high levels of occupational stress and professional victimization. We conducted a cross-sectional study among military police soldiers (n = 452) who were candidates for a military police training course in Bahia, Brazil. All candidates who attended the selection process were evaluated according to the criteria of the National Cholesterol Education Program's Adult Panel III in order to assess the presence of medical disorders that could contribute to cardiovascular disease and metabolic syndrome. The authors identified a high prevalence of hypertension (55.76%), hypertriglyceridemia (50.85%), waist circumference of > 102 cm (31.76%), low high-density lipoprotein cholesterol levels (30.46%), and impaired fasting glucose (28.15%) in our subjects. The overall prevalence of metabolic syndrome was 38.54%. The authors suggest that measures should be taken to ensure that military policemen receive continued medical care, both in their professional capacity and in their personal circumstances, and that attention be focused on intervention programs.
C1 [Braga Filho, Romario Teixeira; D'Oliveira, Argemiro, Jr.] Univ Fed Bahia, BR-40025010 Salvador, BA, Brazil.
C3 Universidade Federal da Bahia
RP Braga, RT (corresponding author), Univ Fed Bahia, Fac Med Bahia, Largo Terreiro Jesus S-N, BR-40025010 Salvador, BA, Brazil.
EM rtbfilho@uol.com.br
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NR 22
TC 15
Z9 17
U1 0
U2 4
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1557-9883
EI 1557-9891
J9 AM J MENS HEALTH
JI Am. J. Mens Health
PD JUL
PY 2014
VL 8
IS 4
BP 310
EP 315
DI 10.1177/1557988313510928
PG 6
WC Public, Environmental & Occupational Health
WE Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA AQ7GO
UT WOS:000342980800005
PM 24284379
DA 2025-06-11
ER

PT J
AU Yang, B
   Kortesniemi, M
AF Yang, Baoru
   Kortesniemi, Maaria
TI Clinical evidence on potential health benefits of berries
SO CURRENT OPINION IN FOOD SCIENCE
LA English
DT Article
ID SEA BUCKTHORN OIL; PLACEBO-CONTROLLED TRIAL; OBESE HUMAN-SUBJECTS;
   CURRANT SEED OIL; METABOLIC SYNDROME; DOUBLE-BLIND; ANTHOCYANIN INTAKE;
   ATOPIC-DERMATITIS; OXIDATIVE STRESS; FLAVONOID INTAKE
AB Recent clinical evidence indicates potential of berry-rich diet in controlling the risk of chronic diseases. Acute consumption of berries ameliorates postprandial glycemic response, improves profile of circulating inflammatory markers and increases antioxidative capacity of plasma. Long-term intake of berries and berry products may improve plasma lipid profile, reduce chronic inflammation and support cardiovascular health, especially in population with baseline metabolic profile of increased risk for metabolic syndrome. Dietary intervention with berry seed oils in early stage of life may reduce prevalence of atopic diseases. More research shall be directed to investigate the potential of berries and berry products in combating stress, promoting healthy aging and improving gut health.
C1 [Yang, Baoru; Kortesniemi, Maaria] Univ Turku, Dept Biochem, Food Chem & Food Dev, FI-20014 Turku, Finland.
C3 Finland National Institute for Health & Welfare; University of Turku
RP Yang, B (corresponding author), Univ Turku, Dept Biochem, Food Chem & Food Dev, FI-20014 Turku, Finland.
EM baoru.yang@utu.fi
RI Yang, Baoru/AAD-6221-2019; Kortesniemi, Maaria/ABU-4856-2022
OI Kortesniemi, Maaria/0000-0003-4273-3459; Yang, Baoru/0000-0001-5561-514X
FU Finnish Cultural Foundation
FX Financial support from the Finnish Cultural Foundation is gratefully
   acknowledged.
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NR 57
TC 77
Z9 88
U1 0
U2 38
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 2214-7993
EI 2214-8000
J9 CURR OPIN FOOD SCI
JI Curr. Opin. Food Sci.
PD APR
PY 2015
VL 2
BP 36
EP 42
DI 10.1016/j.cofs.2015.01.002
PG 7
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA CU5CT
UT WOS:000363550000008
DA 2025-06-11
ER

PT J
AU Najjar, SM
   Russo, L
AF Najjar, Sonia M.
   Russo, Lucia
TI CEACAM1 loss links inflammation to insulin resistance in obesity and
   non-alcoholic steatohepatitis (NASH)
SO SEMINARS IN IMMUNOPATHOLOGY
LA English
DT Review
DE CEACAM1; Insulin resistance; Adipokines; Metabolic syndrome; NASH
ID FATTY-LIVER-DISEASE; TUMOR-NECROSIS-FACTOR; CELL-ADHESION MOLECULE-1;
   KILLER T-CELLS; INDUCED OXIDATIVE STRESS; ENDOPLASMIC-RETICULUM STRESS;
   COLONY-STIMULATING FACTOR; INDUCED HEPATIC STEATOSIS; RECEPTOR TYROSINE
   KINASE; KAPPA-B ACTIVATION
AB Mounting epidemiological evidence points to an association between metabolic syndrome and non-alcoholic steatohepatitis (NASH), an increasingly recognized new epidemic. NASH pathologies include hepatocellular ballooning, lobular inflammation, hepatocellular injury, apoptosis, and hepatic fibrosis. We will review the relationship between insulin resistance and inflammation in visceral obesity and NASH in an attempt to shed more light on the pathogenesis of these major metabolic diseases. Moreover, we will identify loss of the carcinoembryonic antigen-related cell adhesion molecule 1 as a unifying mechanism linking the immunological and metabolic abnormalities in NASH.
C1 [Najjar, Sonia M.; Russo, Lucia] Univ Toledo, Ctr Diabet & Endocrine Res, Toledo, OH 43614 USA.
   [Najjar, Sonia M.; Russo, Lucia] Univ Toledo, Coll Med & Life Sci, Dept Physiol & Pharmacol, Toledo, OH 43614 USA.
C3 University System of Ohio; University of Toledo; University System of
   Ohio; University of Toledo
RP Najjar, SM (corresponding author), Univ Toledo, Ctr Diabet & Endocrine Res, Hlth Sci Campus,3000 Arlington Ave,Mail Stop 1009, Toledo, OH 43614 USA.
EM Sonia.Najjar@utoledo.edu
RI najjar, sonia/GXW-2217-2022
OI najjar, sonia/0000-0001-6209-8902
FU NIH [R01 DK054254, R01 DK083850, R01 HL112248, 5P015PO1 HL036573];
   National Institute of Diabetes and Digestive and Kidney Diseases
   [P30DK020572] Funding Source: NIH RePORTER
FX This work was supported by grants from the NIH R01 DK054254, R01
   DK083850, R01 HL112248, and 5P015PO1 HL036573 to SMN.
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NR 249
TC 33
Z9 37
U1 0
U2 8
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1863-2297
EI 1863-2300
J9 SEMIN IMMUNOPATHOL
JI Semin. Immunopathol.
PD JAN
PY 2014
VL 36
IS 1
BP 55
EP 71
DI 10.1007/s00281-013-0407-3
PG 17
WC Immunology; Pathology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Pathology
GA AA2YI
UT WOS:000330959700005
PM 24258517
OA Green Accepted
DA 2025-06-11
ER

PT J
AU El Midaoui, A
   Haddad, Y
   Filali-Zegzouti, Y
   Couture, R
AF El Midaoui, Adil
   Haddad, Youssef
   Filali-Zegzouti, Younes
   Couture, Rejean
TI Argan Oil as an Effective Nutri-Therapeutic Agent in Metabolic Syndrome:
   A Preclinical Study
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE metabolic syndrome; oxidative stress; kinin receptors; argan oil
ID KININ B-1 RECEPTOR; SUPEROXIDE ANION PRODUCTION; NAD(P)H OXIDASE
   ACTIVATION; INCREASED OXIDATIVE STRESS; EXPERIMENTAL RAT MODEL;
   ALPHA-LIPOIC ACID; ACETYL-L-CYSTEINE; INSULIN-RESISTANCE; VITAMIN-E;
   ARTERIAL-HYPERTENSION
AB The present study aims at examining the effects of argan oil on the three main cardiovascular risk factors associated with metabolic syndrome (hypertension, insulin resistance and obesity) and on one of its main complications, neuropathic pain. Male Sprague-Dawley rats had free access to a drinking solution containing 10% d-glucose or tap water for 12 weeks. The effect of argan oil was compared to that of corn oil given daily by gavage during 12 weeks in glucose-fed rats. Glucose-fed rats showed increases in systolic blood pressure, epididymal fat, plasma levels of triglycerides, leptin, glucose and insulin, insulin resistance, tactile and cold allodynia in association with a rise in superoxide anion production and NADPH oxidase activity in the thoracic aorta, epididymal fat and gastrocnemius muscle. Glucose-fed rats also showed rises in B-1 receptor protein expression in aorta and gastrocnemius muscle. Argan oil prevented or significantly reduced all those anomalies with an induction in plasma adiponectin levels. In contrast, the same treatment with corn oil had a positive impact only on triglycerides, leptin, adiponectin and insulin resistance. These data are the first to suggest that argan oil is an effective nutri-therapeutic agent to prevent the cardiovascular risk factors and complications associated with metabolic syndrome.
C1 [El Midaoui, Adil; Haddad, Youssef; Couture, Rejean] Univ Montreal, Dept Physiol & Pharmacol, Fac Med, Montreal, PQ H3C 3J7, Canada.
   [El Midaoui, Adil; Filali-Zegzouti, Younes] Moulay Ismail Univ, FST Errachidia, Dept Biol, Errachidia, Morocco.
C3 Universite de Montreal; Moulay Ismail University of Meknes
RP El Midaoui, A (corresponding author), Univ Montreal, Dept Physiol & Pharmacol, Fac Med, Montreal, PQ H3C 3J7, Canada.; El Midaoui, A (corresponding author), Moulay Ismail Univ, FST Errachidia, Dept Biol, Errachidia, Morocco.
EM adil.el.midaoui@umontreal.ca; youssef.haddad@umontreal.ca;
   y.filalizegzouti@fste.umi.ac.ma; rejean.couture@umontreal.ca
FU Canadian Institutes of Health Research (CIHR) [MOP-119329]
FX This work was supported by a grant from the Canadian Institutes of
   Health Research (CIHR, MOP-119329) to Rejean Couture. The funder CIHR
   had no role in the design, analysis or writing of this article. The
   authors acknowledge the technical assistance of Jacques Senecal. Argan
   oil was offered graciously by Argan3 Company.
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NR 65
TC 6
Z9 6
U1 0
U2 3
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD NOV
PY 2017
VL 18
IS 11
AR 2492
DI 10.3390/ijms18112492
PG 16
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA FO4KK
UT WOS:000416811300262
PM 29165388
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Kerman, K
   Tement, S
   Korunka, C
AF Kerman, Katja
   Tement, Sara
   Korunka, Christian
TI Don't Leave Your Heart at Work: Profiles of Work-Life Interference and
   Cardiometabolic Risk
SO INTERNATIONAL JOURNAL OF STRESS MANAGEMENT
LA English
DT Article
DE work-life interference; person-oriented approach; latent profile
   analysis; well-being; cardiometabolic risk
ID LATENT CLASS ANALYSIS; OFF-JOB TIME; PSYCHOLOGICAL DETACHMENT; HOME
   INTERFERENCE; FAMILY CONFLICT; RECOVERY; STRESS; HEALTH; INTERRUPTIONS;
   CONSEQUENCES
AB The present study adopts an exploratory, person-oriented approach to investigate possible patterns of work-life interference. We examine work-life interference from a cognitive (i.e., thinking about work), behavioral (i.e., engaging in work-related behavior), and performance perspective (i.e., reduced functionality in private life, or work-life conflict) in order to identify profiles of employees that could potentially remain uncovered with variable-oriented research. Furthermore, as work-life interference relates to wellbeing and health, we were interested in exploring possible differences between profiles in emotional exhaustion, cardiometabolic risk, and health-related behavior. Self-report data on work-life interference and well-being, as well as objective health data, were collected from a heterogeneous sample of 289 employees. Four profiles with different patterns of work-life interference were identified. Out of the four profiles, two profiles reported moderate and high work-life interference (the Moderate Interference and High Interference profiles). The other two profiles revealed distinct combinations of moderate and low performance and behavioral interference (the Low Performance Interference and Low Behavioral Interference profiles). The High Interference and Low Behavioral Interference profiles were identified as risk groups in terms of cardiometabolic health, while the Low Performance Interference and Moderate Interference profiles showed low to no risk. Regarding work-related well-being, the High Interference profile showed the highest risk of emotional exhaustion.
C1 [Kerman, Katja; Korunka, Christian] Univ Vienna, Dept Appl Psychol Work Educ & Econ, Vienna, Austria.
   [Tement, Sara] Univ Maribor, Fac Arts, Dept Psychol, Koroska 160, SI-2000 Maribor, Slovenia.
   [Kerman, Katja] Univ Maribor, Fac Elect Engn & Comp Sci, Inst Informat, Maribor, Slovenia.
C3 University of Vienna; University of Maribor; University of Maribor
RP Tement, S (corresponding author), Univ Maribor, Fac Arts, Dept Psychol, Koroska 160, SI-2000 Maribor, Slovenia.
EM sara.tement@um.si
RI Kerman, Katja/JHU-4394-2023; Tement, Sara/MCJ-5612-2025
OI Tement, Sara/0000-0002-3442-5643; Kerman, Katja/0000-0002-7786-7265
FU Center for Psychological Research and Practice (University of Maribor);
   Slovenian Research Agency-ARRS [J5-9449]; Uni:docs Fellowship Programme
   for Doctoral Candidates (University of Vienna)
FX This research was supported by the Center for Psychological Research and
   Practice (University of Maribor), Slovenian Research Agency-ARRS (Grant
   number: J5-9449), and the Uni:docs Fellowship Programme for Doctoral
   Candidates (University of Vienna).
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NR 85
TC 2
Z9 2
U1 1
U2 19
PU EDUCATIONAL PUBLISHING FOUNDATION-AMERICAN PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST, NE, WASHINGTON, DC 20002-4242 USA
SN 1072-5245
EI 1573-3424
J9 INT J STRESS MANAGE
JI Int. J. Stress Manage.
PD MAY
PY 2021
VL 28
IS 2
BP 105
EP 116
DI 10.1037/str0000224
PG 12
WC Psychology, Applied
WE Social Science Citation Index (SSCI)
SC Psychology
GA SL7ZQ
UT WOS:000657133600002
OA Green Published
DA 2025-06-11
ER

PT J
AU Choi, SH
   Leem, J
   Park, S
   Lee, CK
   Park, KG
   Lee, IK
AF Choi, Seung Hee
   Leem, Jaechan
   Park, Sungmi
   Lee, Chong-Kee
   Park, Keun-Gyu
   Lee, In-Kyu
TI Gemigliptin ameliorates Western-diet-induced metabolic syndrome in mice
SO CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
LA English
DT Article
DE DPP-4 inhibitor; metabolic syndrome; Western diet; adipocyte
   hypertrophy; adipose inflammation; nonalcoholic steatohepatitis;
   AMP-dependent protein kinase; oxidative stress
ID FATTY LIVER-DISEASE; DIPEPTIDYL PEPTIDASE-IV; INSULIN-RESISTANCE;
   HEPATIC STEATOSIS; ADIPOSE-TISSUE; OBESITY; SITAGLIPTIN; INHIBITION;
   STEATOHEPATITIS; INFLAMMATION
AB Dipeptidyl peptidase 4 (DPP-4) inhibitors are widely used antihyperglycemic agents for type 2 diabetes mellitus. Recently, increasing attention has been focused on the pleiotropic actions of DPP-4 inhibitors. The aim of the present study was to examine whether gemigliptin, a recently developed DPP-4 inhibitor, could ameliorate features of metabolic syndrome. Mice were fed a Western diet (WD) for 12 weeks and were subsequently divided into 2 groups: mice fed a WD diet alone or mice fed a WD diet supplemented with gemigliptin for an additional 4 weeks. Gemigliptin treatment attenuated WD-induced body mass gain, hypercholesterolemia, adipocyte hypertrophy, and macrophage infiltration into adipose tissue, which were accompanied by an increased expression of uncoupling protein 1 in subcutaneous fat. These events contributed to improved insulin sensitivity, as assessed by the homeostasis model assessment of insulin resistance and intraperitoneal insulin tolerance test. Furthermore, gemigliptin reduced WD-induced hepatic triglyceride accumulation via inhibition of de novo lipogenesis and activation of fatty acid oxidation, which was accompanied by AMP-dependent protein kinase activation. Gemigliptin ameliorated WD-induced hepatic inflammation and fibrosis through suppression of oxidative stress. These results suggest that DPP-4 inhibitors may represent promising therapeutic agents for metabolic syndrome beyond their current role as antihyperglycemic agents.
C1 [Choi, Seung Hee] Kyungpook Natl Univ, Grad Sch, Dept Biomed Sci, Daegu, South Korea.
   [Leem, Jaechan; Lee, Chong-Kee] Catholic Univ Daegu, Sch Med, Dept Immunol, Daegu, South Korea.
   [Park, Sungmi; Park, Keun-Gyu; Lee, In-Kyu] Kyungpook Natl Univ, Leading Edge Res Ctr Drug Discovery & Dev Diabet, Daegu, South Korea.
   [Park, Keun-Gyu; Lee, In-Kyu] Kyungpook Natl Univ, Sch Med, Dept Internal Med, Div Endocrinol & Metab, Daegu, South Korea.
   [Lee, In-Kyu] Kyungpook Natl Univ, Plus KNU Biomed Convergence Program BK21, Daegu, South Korea.
C3 Kyungpook National University (KNU); Catholic University of Daegu;
   Kyungpook National University (KNU); Kyungpook National University
   (KNU); Kyungpook National University (KNU)
RP Lee, IK (corresponding author), Kyungpook Natl Univ, Leading Edge Res Ctr Drug Discovery & Dev Diabet, Daegu, South Korea.; Lee, IK (corresponding author), Kyungpook Natl Univ, Sch Med, Dept Internal Med, Div Endocrinol & Metab, Daegu, South Korea.; Lee, IK (corresponding author), Kyungpook Natl Univ, Plus KNU Biomed Convergence Program BK21, Daegu, South Korea.
EM leei@knu.ac.kr
RI Leem, Jaechan/AAQ-6648-2020; Lee, In-Kyu/AAR-6374-2021
OI Leem, Jaechan/0000-0003-2329-4374; choi, seunghee/0000-0001-5239-0192
FU National Research Foundation of Korea grant - Korean Ministry of
   Education [2012R1A2A1A03670452]; Korea Health Technology R&D project
   through the Korea Health Industry Development Institute (KHIDI);
   Ministry of Health & Welfare, Republic of Korea [HI16C1501]
FX This work was supported by a National Research Foundation of Korea grant
   awarded by the Korean Ministry of Education (2012R1A2A1A03670452) and a
   grant of the Korea Health Technology R&D project through the Korea
   Health Industry Development Institute (KHIDI), funded by the Ministry of
   Health & Welfare, Republic of Korea (HI16C1501).
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NR 37
TC 14
Z9 15
U1 0
U2 10
PU CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS
PI OTTAWA
PA 65 AURIGA DR, SUITE 203, OTTAWA, ON K2E 7W6, CANADA
SN 0008-4212
EI 1205-7541
J9 CAN J PHYSIOL PHARM
JI Can. J. Physiol. Pharmacol.
PD FEB
PY 2017
VL 95
IS 2
BP 129
EP 139
DI 10.1139/cjpp-2016-0026
PG 11
WC Pharmacology & Pharmacy; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Physiology
GA EM6KK
UT WOS:000395421200004
PM 27918207
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Scheen, AJ
AF Scheen, Andre J.
TI The Endocannabinoid System: A Promising Target for the Management of
   Type 2 Diabetes
SO CURRENT PROTEIN & PEPTIDE SCIENCE
LA English
DT Review
DE Endocannabinoid system; cardiometabolic risk; CB1 receptor; obesity;
   rimonabant; type 2 diabetes
ID CB1 RECEPTOR ANTAGONIST; CARDIOMETABOLIC RISK-FACTORS; FOOD-REINFORCED
   BEHAVIOR; DIET-INDUCED OBESITY; BODY-MASS INDEX; CANNABINOID CB1;
   ADIPOSE-TISSUE; WEIGHT-LOSS; CARDIOVASCULAR-DISEASE; GLYCEMIC CONTROL
AB Type 2 diabetes is closely related to abdominal obesity and is generally associated with other cardiometabolic risk factors, resulting in a high incidence of cardiovascular complications. Several animal and human observations suggest that the endocannabinoid (EC) system is overactivated in presence of abdominal obesity and/or diabetes, and contributes to disturbances of energy balance and metabolism. Not only it regulates the intake of nutrients through central mechanisms located within the hypothalamus and limbic area, but it also intervenes in transport, metabolism and deposit of the nutrients in the digestive tract, liver, adipose tissue, skeletal muscle, and possibly pancreas. Activation of both central and peripheral CB1 receptors promotes weight gain and associated metabolic changes. Conversely, rimonabant, the first selective CB1 receptor antagonist in clinical use, has been shown to reduce body weight, waist circumference, triglycerides, blood pressure, insulin resistance and C-reactive protein levels, and to increase HDL cholesterol and adiponectin concentrations in both non-diabetic and diabetic overweight/obese patients. In addition, a 0.5-0.7% reduction in glycated hemoglobin (HbA1c) levels was observed in metformin- or sulfonylurea-treated patients with type 2 diabetes and in drug-naive or insulin-treated diabetic patients. Almost half of metabolic changes occurred beyond weight loss, in agreement with direct peripheral effects. Rimonabant was generally well-tolerated, but with a slightly higher incidence of depressed mood disorders, anxiety, nausea and dizziness compared to placebo. New trials are supposed to confirm the potential role of rimonabant (and other CB1 neutral antagonists or inverse agonists) in overweight/obese patients with type 2 diabetes and high risk cardiovascular disease.
C1 [Scheen, Andre J.] Univ Liege, CHU Sart Tilman, Div Diabet Nutr & Metab Disorders, Liege, Belgium.
   [Scheen, Andre J.] Univ Liege, CHU Sart Tilman, Clin Pharmacol Unit, Liege, Belgium.
C3 University of Liege; University of Liege
RP Scheen, AJ (corresponding author), CHU Sart Tilman B35, Dept Med, Div Diabet Nutr & Metab Disorders, B-4000 Liege, Belgium.
EM andre.scheen@chu.ulg.ac.be
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   ACOMPLIA EUROPEAN PU
NR 161
TC 25
Z9 27
U1 0
U2 6
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1389-2037
EI 1875-5550
J9 CURR PROTEIN PEPT SC
JI Curr. Protein Pept. Sci.
PD FEB
PY 2009
VL 10
IS 1
BP 56
EP 74
DI 10.2174/138920309787315149
PG 19
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 415WZ
UT WOS:000263968500008
PM 19275673
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Mejia-Valdez, D
   Antunes-Ricardo, M
   Martínez-Avila, M
   Ortega-Hernandez, E
   Guajardo-Flores, D
AF Mejia-Valdez, Daniel
   Antunes-Ricardo, Marilena
   Martinez-Avila, Mariana
   Ortega-Hernandez, Erika
   Guajardo-Flores, Daniel
TI Liposomal encapsulation of Chenopodium berlandieri extracts rich
   in oleanolic acid: improved bioactivities targeting metabolic syndrome
   prevention
SO FOOD & FUNCTION
LA English
DT Article; Early Access
ID ANTIOXIDANT; SAPONINS; BIOAVAILABILITY; EFFICIENCY; STRESS; QUINOA; PH
AB Chronic inflammation and oxidative stress are major contributors to the development of metabolic syndrome conditions, including obesity, insulin resistance, dyslipidemia, and hypertension. These interconnected disorders significantly impact global health and demand preventive strategies. We encapsulated extracts from Chenopodium berlandieri-a Mexican edible pseudocereal rich in oleanolic acid (OA)-into liposomes to improve their bioactivity and delivery. Liposomes prepared via thin-film hydration followed by sonication showed particle sizes between 100 and 130 nm, narrow size distributions (PdI < 0.25), and zeta potentials from -6.3 to -7.6 mV. Encapsulation efficiencies exceeded 80%. In vitro release studies demonstrated sustained OA release, with over 80% released at 12 hours for OA and hydrolyzed extract liposomes. Cytotoxicity assays on human dermal fibroblasts confirmed lipid safety at physiologically relevant concentrations. Liposomal formulations significantly improved cellular antioxidant activity and nitric oxide inhibition compared to non-encapsulated samples. They also enhanced IL-10 production and reduced levels of pro-inflammatory markers including IL-6, TNF-alpha, and IL-1 beta. Additionally, liposomes downregulated COX-2 and inhibited elastase, collagenase, and hyaluronidase-enzymes involved in extracellular matrix (ECM) degradation, which contributes to tissue damage and inflammation in metabolic syndrome. These responses were most pronounced in liposomes loaded with hydrolyzed extracts. Overall, liposomal encapsulation enhanced the physicochemical stability, release behavior, and functional bioactivities of C. berlandieri bioactives, supporting their potential as functional food ingredients for metabolic syndrome prevention.
C1 [Mejia-Valdez, Daniel; Antunes-Ricardo, Marilena; Martinez-Avila, Mariana; Ortega-Hernandez, Erika; Guajardo-Flores, Daniel] Tecnol Monterrey, Ctr Biotecnol FEMSA, Av Eugenio Garza Sada 2501 Sur, Monterrey 64849, Nuevo Leon, Mexico.
   [Antunes-Ricardo, Marilena] Tecnol Monterrey, Inst Obes Res, Ave Eugenio Garza Sada 2501, Monterrey 64849, NL, Mexico.
C3 Tecnologico de Monterrey; Tecnologico de Monterrey
RP Guajardo-Flores, D (corresponding author), Tecnol Monterrey, Ctr Biotecnol FEMSA, Av Eugenio Garza Sada 2501 Sur, Monterrey 64849, Nuevo Leon, Mexico.
EM danielgdo@tec.mx
RI Ortega, Erika/AAD-8579-2020; Guajardo-Flores, Daniel/HNI-9307-2023
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NR 63
TC 0
Z9 0
U1 0
U2 0
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PD 2025 MAY 28
PY 2025
DI 10.1039/d5fo01572c
EA MAY 2025
PG 14
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA 3FA4J
UT WOS:001498782600001
PM 40439562
DA 2025-06-11
ER

PT J
AU Wang, Q
   Chair, SY
   Wong, EML
   Qiu, XCH
AF Wang, Qun
   Chair, Sek Ying
   Wong, Eliza Mi Ling
   Qiu, Xichenhui
TI Actively incorporating lifestyle modifications into daily life: The key
   to adherence in a lifestyle intervention programme for metabolic
   syndrome
SO FRONTIERS IN PUBLIC HEALTH
LA English
DT Article
DE adherence; lifestyle intervention; metabolic syndrome; qualitative
   research; experiences
ID QUALITY-OF-LIFE; ADULTS; OUTCOMES; WOMEN; RISK
AB IntroductionLifestyle modifications are the first-line interventions for metabolic syndrome (MetS) management. The effectiveness of lifestyle interventions depends mostly on participants' adherence to the interventions. The current study was to explore the experiences of MetS patients in attending lifestyle intervention program (LIP) and the factors that influenced their adherence to the interventions. MethodsA descriptive qualitative study was designed following the COREQ guideline. Face-to-face semi-structured individual interviews were conducted with a purposive sample from the participants who attended the LIP using the data saturation principle. Content analysis of transcripts was conducted following the methods proposed by Graneheim and Lundman. ResultsThe study recruited 27 participants, including 13 males and 14 females. Four themes were identified: (i) the positive and beneficial experiences of attending the LIP, including incorporating lifestyle modifications into daily life, improved physical and psychological health, and empowerment; (ii) facilitators of adherence, including individualized lifestyle education, regular follow-ups, and adequate interpersonal support; (iii) barriers to adherence, including personal resistance, competing demands, and contextual factors; (iv) suggestions for future interventions: with multidisciplinary team, longer term intervention, and more efficient approaches. The findings also indicated that young-to-middle aged patients faced more conflicts with role-related commitments, and were open for e-approaches in lifestyle interventions. ConclusionThe LIP provided positive and beneficial experiences for the participants. Actively incorporating lifestyle modifications into daily life is the key to maintain participants' adherence to the LIP. Culturally appropriate and psycho-behavioral strategies should be adopted to overcome personal and contextual barriers. Special attentions should be paid for the young-to-middle aged population in MetS management.
C1 [Wang, Qun; Qiu, Xichenhui] Shenzhen Univ, Sch Nursing, Shenzhen, Peoples R China.
   [Chair, Sek Ying] Chinese Univ Hong Kong, Nethersole Sch Nursing, Shatin, Hong Kong, Peoples R China.
   [Wong, Eliza Mi Ling] Tung Wah Coll, Sch Nursing, Kowloon, Hong Kong, Peoples R China.
C3 Shenzhen University; Chinese University of Hong Kong; Tung Wah College
RP Qiu, XCH (corresponding author), Shenzhen Univ, Sch Nursing, Shenzhen, Peoples R China.
EM qiuxichenhui@163.com
RI WANG, Qun/AAP-9908-2021; Wong, Eliza/AAH-6193-2020; Chair,
   Sek/IVV-5916-2023; Chair, Sek Ying/G-9965-2016
OI Chair, Sek Ying/0000-0003-2387-7035
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NR 32
TC 6
Z9 6
U1 0
U2 7
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 2296-2565
J9 FRONT PUBLIC HEALTH
JI Front. Public Health
PD AUG 1
PY 2022
VL 10
AR 929043
DI 10.3389/fpubh.2022.929043
PG 10
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA 3Z7TY
UT WOS:000844620600001
PM 35979455
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Watkins, A
   Rosenbaum, S
   Ward, PB
   Patching, J
   Denney-Wilson, E
   Stein-Parbury, J
AF Watkins, Andrew
   Rosenbaum, Simon
   Ward, Philip B.
   Patching, Joanna
   Denney-Wilson, Elizabeth
   Stein-Parbury, Jane
TI The Validity and reliability characteristics of the M-BacK Questionnaire
   to assess the Barriers, attitudes, confidence, and Knowledge of Mental
   health staff regarding Metabolic health of Mental health service Users
SO FRONTIERS IN PUBLIC HEALTH
LA English
DT Article
DE severe mental illness; physical health; education; training; evaluation
   tool; service delivery; health outcomes; metabolic syndrome
ID LIFE-STYLE INTERVENTIONS; PHYSICAL HEALTH; NURSES ATTITUDES; TRAINING
   NEEDS; PEOPLE; ILLNESS; CARE; SCHIZOPHRENIA; RISK; ADULTS
AB Background: Addressing the burden of poor physical health and the subsequent gap in life expectancy experienced by people with mental illness is a major priority in mental health services. To equip mental health staff with the competence to deliver evidence-based interventions, targeted staff training regarding metabolic health is required. In order to evaluate the effectiveness of staff training regarding metabolic health, we aimed to develop a succinct measure to determine the barriers, attitudes, confidence, and knowledge of health practitioners through the development and test-retest reliability of the Metabolic-Barriers, Attitudes, Confidence, and Knowledge Questionnaire (M-BACK).
   Methods: The M-BACK questionnaire was developed to evaluate the impact of specialized training in metabolic health care for mental health nurses. Content of the M-BACK was developed from a literature review and refined by an expert review panel and validated via a piloting process. To determine the test-retest reliability of the M-BACK, 31 nursing students recruited from the University of Notre Dame, Sydney completed the questionnaire on two separate occasions, 7 days apart. Intraclass correlation coefficients (ICCs) were calculated for the total score, as well as each of the four domains.
   Results: Pilot testing was undertaken with a sample of 106 mental health nurses with a mean age 48.2, ranging from 24 to 63 years of age, who participated in six training courses. Questionnaire development resulted in a 16-item instrument, with each item is scored on a five-point Likert scale ranging from "strongly disagree" to "strongly agree." Test-retest reliability of the M-BACK was completed by 30 of 31 nursing students recruited, ICCs ranged from 0.62 to 0.96.
   Conclusion: The M-BACK is a reliable measure of the key elements of practitioner perceptions of barriers, and their knowledge, attitudes, and confidence regarding metabolic monitoring in people with mental illness. It can be used to assess the effectiveness of interventions aimed at increasing uptake of metabolic monitoring, a key component of programs to reduce the life expectancy gap in people living with severe mental illness.
C1 [Watkins, Andrew] South Eastern Sydney Local Hlth Dist, Keeping Body Mind Program, Bondi Ctr, Sydney, NSW, Australia.
   [Watkins, Andrew; Denney-Wilson, Elizabeth; Stein-Parbury, Jane] Univ Technol Sydney, Fac Hlth, Sydney, NSW, Australia.
   [Rosenbaum, Simon; Ward, Philip B.] Univ New South Wales, Sch Psychiat, Sydney, NSW, Australia.
   [Ward, Philip B.] Ingham Inst Appl Med Res, Schizophrenia Res Unit, Liverpool, NSW, Australia.
   [Patching, Joanna] Univ Notre Dame, Sch Nursing, Sydney, NSW, Australia.
C3 South Eastern Sydney Local Health District; University of Technology
   Sydney; University of New South Wales Sydney; Ingham Institute for
   Applied Medical Research; The University of Notre Dame Australia
RP Watkins, A (corresponding author), South Eastern Sydney Local Hlth Dist, Keeping Body Mind Program, Bondi Ctr, Sydney, NSW, Australia.; Watkins, A (corresponding author), Univ Technol Sydney, Fac Hlth, Sydney, NSW, Australia.
EM andrew.watkins@health.nsw.gov.au
RI Rosenbaum, Simon/Y-3241-2019; Ward, Philip/JCE-6293-2023
OI Ward, Philip/0000-0002-5779-7722; Rosenbaum, Simon/0000-0002-8984-4941;
   Watkins, Andrew/0000-0003-3452-8682
CR [Anonymous], MENTAL HLTH PRACTICE
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NR 45
TC 17
Z9 19
U1 0
U2 5
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 2296-2565
J9 FRONT PUBLIC HEALTH
JI Front. Public Health
PD DEC 11
PY 2017
VL 5
AR 321
DI 10.3389/fpubh.2017.00321
PG 8
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA FP7AY
UT WOS:000417779900001
PM 29312914
OA gold, Green Published
DA 2025-06-11
ER

PT S
AU Xiao, LJ
   Tao, R
AF Xiao, Li-Jun
   Tao, Ran
BE Zhang, X
   Shi, J
   Tao, R
TI Nutrition Support Therapy
SO SUBSTANCE AND NON-SUBSTANCE ADDICTION
SE Advances in Experimental Medicine and Biology
LA English
DT Article; Book Chapter
DE Nutrition intervention; Dietary behaviors; Nutritional deficiency; Omega
   3 fatty acids; Nutrition education; Metabolic systems; Disorders of
   eating; Nutrition assessment
ID SEROTONERGIC DYSFUNCTION; METABOLIC SYNDROME; SUBSTANCE; ADDICTION;
   ANXIETY; ACID; FOOD
AB In most addictions, serious nutritional deficiencies of major proteins, fats, vitamins and minerals exist which prevent their capability to digest carbohydrates efficiently. This review aims to point out some treatment approaches in nutrition management for alcohol addiction, drug addiction, food addiction, Internet addiction and sex addiction, according to existing literatures.
C1 [Xiao, Li-Jun; Tao, Ran] PLA Army Gen Hosp, Dept Psychol Med, Beijing 100700, Peoples R China.
RP Xiao, LJ (corresponding author), PLA Army Gen Hosp, Dept Psychol Med, Beijing 100700, Peoples R China.
EM bjptaoran@126.com
RI xiao, ming/KHT-1774-2024
CR [Anonymous], INT J ENV RES PUBLIC
   [Anonymous], 2010, WORLD DRUG REP
   [Anonymous], DEF TERMS STYL CONV
   [Anonymous], 2014, EATING DISORDERS ADD
   [Anonymous], GROUP PROGRAMS WEIGH
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NR 28
TC 4
Z9 6
U1 0
U2 9
PU SPRINGER-VERLAG SINGAPORE PTE LTD
PI SINGAPORE
PA 152 BEACH ROAD, #21-01/04 GATEWAY EAST, SINGAPORE, 189721, SINGAPORE
SN 0065-2598
EI 2214-8019
BN 978-981-10-5562-1; 978-981-10-5561-4
J9 ADV EXP MED BIOL
JI Adv.Exp.Med.Biol.
PY 2017
VL 1010
BP 281
EP 293
DI 10.1007/978-981-10-5562-1_14
D2 10.1007/978-981-10-5562-1
PG 13
WC Substance Abuse; Medicine, Research & Experimental
WE Book Citation Index – Science (BKCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Substance Abuse; Research & Experimental Medicine
GA BJ9IE
UT WOS:000429224300015
PM 29098678
DA 2025-06-11
ER

PT J
AU Paul-Labrador, M
   Polk, D
   Dwyer, JH
   Velasquez, I
   Nidich, S
   Rainforth, M
   Schneider, R
   Merz, NB
AF Paul-Labrador, Maura
   Polk, Donna
   Dwyer, James H.
   Velasquez, Ivan
   Nidich, Sanford
   Rainforth, Maxwell
   Schneider, Robert
   Merz, Noel Bairey
TI Effects of a randomized controlled trial of transcendental meditation on
   components of the metabolic syndrome in subjects with coronary heart
   disease
SO ARCHIVES OF INTERNAL MEDICINE
LA English
DT Article
ID HOMEOSTASIS MODEL ASSESSMENT; OLDER AFRICAN-AMERICANS; PITUITARY-ADRENAL
   AXIS; INTIMA-MEDIA THICKNESS; MIDDLE-AGED MEN; ARTERY-DISEASE;
   INSULIN-RESISTANCE; STRESS REDUCTION; CARDIOVASCULAR-DISEASE;
   MYOCARDIAL-ISCHEMIA
AB Background: The metabolic syndrome is thought to be a contributor to coronary heart disease (CHD), and components of the syndrome have been identified as possible therapeutic targets. Previous data implicate neurohumoral activation related to psychosocial stress as a contributor to the metabolic syndrome. The aim of this study was to evaluate the efficacy of transcendental meditation (TM) on components of the metabolic syndrome and CHD.
   Methods: We conducted a randomized, placebo-controlled clinical trial of 16 weeks of TM or active control treatment (health education), matched for frequency and time, at an academic medical center in a total of 103 subjects with stable CHD. Main outcome measures included blood pressure, lipoprotein profile, and insulin resistance determined by homeostasis model assessment (calculated as follows: [(fasting plasma glucose level [in milligrams per deciliter] x fasting plasma insulin level [in microunits per milliliter]) x 0.0552]/22.5); endothelial function measured by brachial artery reactivity testing; and cardiac autonomic system activity measured by heart rate variability.
   Results: The TM group had beneficial changes ( measured as mean +/- SD) in adjusted systolic blood pressure (- 3.4 +/- 2.0 vs 2.8 +/- 2.1 mm Hg; P= .04), insulin resistance (- 0.75 +/- 2.04 vs 0.52 +/- 2.84; P = .01), andheart rate variability (0.10 +/- 0.17 vs - 0.50 +/- 0.17 high- frequency power; P = .07) compared with the health education group, respectively. There was no effect of brachial artery reactivity testing.
   Conclusions: Use of TM for 16 weeks in CHD patients improved blood pressure and insulin resistance components of the metabolic syndrome as well as cardiac autonomic nervous system tone compared with a control group receiving health education. These results suggest that TM may modulate the physiological response to stress and improve CHD risk factors, which may be a novel therapeutic target for the treatment of CHD.
C1 Cedars Sinai Res Inst, Cedars Sinai Med Ctr, Dept Med, Div Cardiol, Los Angeles, CA 90048 USA.
   Univ So Calif, Dept Prevent Med, Keck Sch Med, Los Angeles, CA 90089 USA.
   Maharishi Univ Management, Inst Nat Med & Prevent, Maharishi Vedic, IA USA.
C3 Cedars Sinai Medical Center; University of Southern California
RP Merz, NB (corresponding author), Cedars Sinai Res Inst, Cedars Sinai Med Ctr, Dept Med, Div Cardiol, 444 S San Vicente Blvd,Suite 901, Los Angeles, CA 90048 USA.
EM merz@cshs.org
RI Velasquez, Ivan/AFC-7234-2022
FU NCCIH NIH HHS [R01 AT00226] Funding Source: Medline; NCRR NIH HHS
   [M01-RR00425] Funding Source: Medline; NHLBI NIH HHS [R01-HL51519-08,
   1-R15-HL660242-01] Funding Source: Medline; NIAAA NIH HHS
   [1-P50-AA0082-02] Funding Source: Medline
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NR 51
TC 155
Z9 183
U1 1
U2 26
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 0003-9926
EI 1538-3679
J9 ARCH INTERN MED
JI Arch. Intern. Med.
PD JUN 12
PY 2006
VL 166
IS 11
BP 1218
EP 1224
DI 10.1001/archinte.166.11.1218
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA 051YS
UT WOS:000238198200011
PM 16772250
DA 2025-06-11
ER

PT J
AU Meichtry, LB
   da Silva, GS
   Londero, L
   Dahleh, MMM
   Bortolotto, VC
   Araujo, SM
   Musachio, EA
   da Silva, DT
   Emanuelli, T
   Carric, MRS
   Roehrs, R
   Guerra, GP
   Prigol, M
AF Meichtry, Luana Barreto
   da Silva, Guilherme Silva
   Londero, Larissa
   Dahleh, Mustafa Munir Mustafa
   Bortolotto, Vandreza Cardoso
   Araujo, Stifani Machado
   Musachio, Elize Aparecida
   da Silva, Dariane Trivisiol
   Emanuelli, Tatiana
   Carric, Murilo Ricardo Sigal
   Roehrs, Rafael
   Guerra, Gustavo Petri
   Prigol, Marina
TI Exposure to Trans Fat During the Developmental Period of
   Drosophila melanogaster Alters the Composition of Fatty Acids
   in the Head and Induces Depression-like Behavior
SO NEUROSCIENCE
LA English
DT Article
DE fatty acids; neuronal membranes; behavioral disorders; dietary
   composition; serotonin
ID METABOLIC SYNDROME; HIPPOCAMPUS; MECHANISMS; ANHEDONIA; ANXIETY; MODELS;
   SYSTEM; MEMORY; BDNF; DIET
AB the importance of understanding the disorders caused by trans fatty acids (TFAs), this study sought to add different concentrations hydrogenated vegetable fat (HVF) to the diet of Drosophila melanogaster during the developmental period and evaluate the effects on neurobehavioral parameters. Longevity, hatching rate, and behavioral functions were assessed, such as negative geotaxis, forced swimming, light/dark, mating, and aggressiveness. The fatty acids (FAs) present in the heads of the flies were quantified as well as serotonin (5HT) and dopamine (DA) levels. Our findings showed that flies that received HVF at all concentrations during development showed reduced longevity and hatching rates, in addition to increased depression-like, anxiouslike, anhedonia-like, and aggressive behaviors. As for the biochemical parameters, there was a more significant presence of TFA in flies exposed to HVF at all concentrations evaluated and lower 5HT and DA levels. This study shows that HVF during the developmental phase can cause neurological changes and consequently induce behavioral disorders, thereby highlighting the importance of the type of FA offered in the early stages of life.(c) 2023 IBRO. Published by Elsevier Ltd. All rights reserved.
C1 [Meichtry, Luana Barreto; da Silva, Guilherme Silva; Londero, Larissa; Dahleh, Mustafa Munir Mustafa; Bortolotto, Vandreza Cardoso; Araujo, Stifani Machado; Musachio, Elize Aparecida; Guerra, Gustavo Petri; Prigol, Marina] Univ Fed Pampa Campus Itaqui, Lab Avaliacoes Farmacolg & Toxicol, Aplicadas Moleculas Bioat LaftamBio Pampa, Rua Luiz Joaquim Sa Britto, BR-97650000 Itaqui, RS, Brazil.
   [da Silva, Dariane Trivisiol; Emanuelli, Tatiana] Ctr Ciencias Rurais Univ Fed Santa Maria, Dept Tecnol & Ciencia Alimentos, BR-97105900 Santa Maria, RS, Brazil.
   [Carric, Murilo Ricardo Sigal; Roehrs, Rafael] Univ Fed Pampa Campus Uruguaiana, Programa Posgraduacao Bioquim PPGBioq, BR-472 Km 7, BR-97501970 Uruguaiana, Brazil.
C3 Universidade Federal do Pampa
RP Prigol, M (corresponding author), Univ Fed Pampa Campus Itaqui, Lab Avaliacoes Farmacolg & Toxicol, Aplicadas Moleculas Bioat LaftamBio Pampa, Rua Luiz Joaquim Sa Britto, BR-97650000 Itaqui, RS, Brazil.
EM marinaprigol@gmail.com
RI Dahleh, Mustafa/AAG-1793-2021; Roehrs, Rafael/F-8413-2012; Emanuelli,
   Tatiana/AAX-9075-2020; Prigol, Marina/E-9316-2015; Petri Guerra,
   Gustavo/AGQ-7865-2022
OI Emanuelli, Tatiana/0000-0003-0168-3416; Petri Guerra,
   Gustavo/0000-0001-6995-5348; Musachio, Elize/0000-0002-2577-2379
FU Higher Education Personnel Improvement Coordination (CAPES) [001];
   National Council for Scientific and Technological Development (CNPq) [PQ
   308120/2020-5]; Research Support Foundation of the State of Rio Grande
   do Sul (FAPERGS) [PQG19/2551-0001913-0]
FX This work was supported by grants from the Higher Education Personnel
   Improvement Coordination (CAPES) (001) , the National Council for
   Scientific and Technological Development (CNPq) (PQ 308120/2020-5) , and
   the Research Support Foundation of the State of Rio Grande do Sul
   (FAPERGS) (PQG19/2551-0001913-0) .
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NR 56
TC 2
Z9 2
U1 1
U2 8
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4522
EI 1873-7544
J9 NEUROSCIENCE
JI Neuroscience
PD MAY 21
PY 2023
VL 519
BP 10
EP 22
DI 10.1016/j.neuroscience.2023.03.015
EA MAR 2023
PG 13
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA E0IS4
UT WOS:000972480500001
PM 36933760
DA 2025-06-11
ER

PT J
AU Graham, JN
   Desroches, BR
   Weiss, JP
AF Graham, John N., Jr.
   Desroches, Bethany R.
   Weiss, Jeffrey P.
TI Nocturia causes vary with each decade
SO CURRENT OPINION IN UROLOGY
LA English
DT Review
DE definition; depression; incidence; LUTS; nocturia; nocturnal polyuria;
   prevalence; reduced bladder capacity; sleep; storage
ID URINARY-TRACT SYMPTOMS; POPULATION DECREASES OVERESTIMATION; PREVALENCE;
   ASSOCIATION; POLYURIA; MEN; STANDARDIZATION; TERMINOLOGY; DEFINITION;
   HEALTH
AB Purpose of review
   To review the published literature within the last 18 months that comment on the causes of nocturia, varying with age. The causes are categorized into organized subsets: nocturnal polyuria, storage or reduced bladder capacity, 24-h polyuria, and sleep-associated nocturia.
   Recent findings
   Prevalence of nocturia is high, but has been reported at varying rates in the epidemiologic studies. Similarly, reported incidence has a high rate of variability. Nocturia causes were associated with nocturnal polyuria, bladder storage issues, metabolic syndrome, abnormal bowel habits, obesity, Parkinson's disease, global polyuria, insomnia, sleep disturbances, heart failure, anxiety, and depression. Although age was commented on in many articles, it was never the primary examined variable.
   Summary
   There is a lack of standardization in definition and classification of the causes of nocturia. Confounding variables included a lack of use of a standard definition of nocturia, identifying nocturia at its true onset, and a fundamental underutilization of frequency volume charts to identify patients with nocturia. The confounding variables make it difficult to compare studies. Thus, the strength of conclusion on cause will be better defined when standards are set controlling definition, identification, and diagnosis.
C1 [Graham, John N., Jr.; Desroches, Bethany R.; Weiss, Jeffrey P.] SUNY Downstate Coll Med, Dept Urol, Brooklyn, NY 11203 USA.
C3 State University of New York (SUNY) System; SUNY Downstate Health
   Sciences University
RP Graham, JN (corresponding author), SUNY Downstate Coll Med, Dept Urol, 450 Clarkson Ave, Brooklyn, NY 11203 USA.
EM john.graham@downstate.edu
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NR 30
TC 7
Z9 7
U1 0
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0963-0643
EI 1473-6586
J9 CURR OPIN UROL
JI Curr. Opin. Urol.
PD JUL
PY 2014
VL 24
IS 4
BP 358
EP 362
DI 10.1097/MOU.0000000000000061
PG 5
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA AI8HM
UT WOS:000337152600006
PM 24809414
DA 2025-06-11
ER

PT J
AU Daniel, M
   Lekkas, P
   Cargo, M
AF Daniel, Mark
   Lekkas, Peter
   Cargo, Margaret
TI Environments and Cardiometabolic Diseases in Aboriginal Populations
SO HEART LUNG AND CIRCULATION
LA English
DT Article; Proceedings Paper
CT 1st Indigenous Cardiovascular Health Conference of the
   Cardiac-Society-of-Australia-and-New-Zealand
CY AUG 16-17, 2009
CL Sydney, AUSTRALIA
SP Cardiac Soc Australia & New Zealand
DE Aboriginal, Indigenous peoples; Cardiovascular, metabolic disease;
   Social, built, physical environments; Biopsychosocial pathways
ID URBAN INDIGENOUS AUSTRALIANS; CARDIOVASCULAR-DISEASE; NEW-ZEALAND;
   NORTHERN-TERRITORY; RISK-FACTORS; PARTICIPATORY RESEARCH;
   AMERICAN-INDIANS; HEALTH; MORTALITY; REMOTE
AB This review establishes the relevance and frames the relationship of environmental factors to cardiometabolic risk factors and disease in Aboriginal populations. Environmental factors operate at the level of communities or populations. They include contextual measures of places and compositional measures of populations which together constitute "risk conditions" affecting individual risk factors. Environmental factors have been implicated by contrasting Aboriginal and non-Aboriginal populations in cardiometabolic risk factors and outcomes, or by geographic contrasts of Aboriginal populations in remote, rural and urban regions. It is unclear whether heterogeneity in contextual or compositional factors between and within Aboriginal populations is associated with heterogeneity in cardiometabolic risk factors and outcomes. Empirical literature that links environmental factors and cardiometabolic outcomes in Aboriginal populations is critically reviewed for three postulated pathways of influence: (1) behaviour; (2) psychosocial factors; and (3) stress response axes. These pathways, represented as interdependent, can explain how and why environments are associated with cardiometabolic outcomes. The need remains, however, to develop a robust quantitative evidence base in cardiometabolic research aimed at enhancing knowledge of the specific environmental factors related to the cardiometabolic health of Aboriginal populations as well as explicating the underlying mechanisms by which environmental risk conditions 'get under the skin'. (Heart, Lung and Circulation 2010;19:306-315) (C) 2010 Australasian Society of Cardiac and Thoracic Surgeons and the Cardiac Society of Australia and New Zealand. Published by Elsevier Inc. All rights reserved.
C1 [Daniel, Mark] Univ S Australia, Sansom Inst, Res Chair Social Epidemiol, Adelaide, SA 5001, Australia.
   [Daniel, Mark] Univ Melbourne, Dept Med, St Vincents Hosp, Melbourne, Vic 3010, Australia.
C3 University of South Australia; St Vincent's Health; St Vincent's
   Hospital Melbourne; NSW Health; St Vincents Hospital Sydney; University
   of Melbourne
RP Daniel, M (corresponding author), Univ S Australia, Sansom Inst, Res Chair Social Epidemiol, GPO Box 2471, Adelaide, SA 5001, Australia.
EM mark.daniel@unisa.edu.au
RI Daniel, Mark/A-1151-2009; Cargo, Margaret/B-2141-2010
OI Lekkas, Peter/0009-0008-1057-8494; Daniel, Mark/0000-0001-9112-134X
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NR 81
TC 19
Z9 20
U1 0
U2 7
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1443-9506
EI 1444-2892
J9 HEART LUNG CIRC
JI Heart Lung Circ.
PD MAY-JUN
PY 2010
VL 19
IS 5-6
SI SI
BP 306
EP 315
DI 10.1016/j.hlc.2010.01.005
PG 10
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Cardiovascular System & Cardiology
GA 610WA
UT WOS:000278768400009
PM 20356789
DA 2025-06-11
ER

PT J
AU Miller, GE
   Rohleder, N
   Cole, SW
AF Miller, Gregory E.
   Rohleder, Nicolas
   Cole, Steve W.
TI Chronic Interpersonal Stress Predicts Activation of Pro- and
   Anti-inflammatory Signaling Pathways 6 Months Later
SO PSYCHOSOMATIC MEDICINE
LA English
DT Article
DE stress; social support; social conflict; inflammation; glucocorticoid
   receptor; cytokines
ID SOCIAL RELATIONSHIPS; METABOLIC SYNDROME; MARITAL QUALITY;
   SUSCEPTIBILITY; DEPRESSION; INFLAMMATION; PERSPECTIVE; CYTOKINES;
   IMMUNITY; DISEASE
AB Objective: To understand the mechanisms underlying chronic interpersonal difficulties and their detrimental influence on mental and physical health. Methods: A total of 103 healthy young women (mean age = 17 years) were administered a structured interview to assess the degree of chronic interpersonal stress in their lives. At the same time, blood was drawn to measure systemic inflammation, the expression of signaling molecules that regulate immune activation, and leukocyte production of the cytokine interleukin-6 after ex vivo stimulation with lipopolysaccharide. All of the immunologic assessments were repeated 6 months later. Results: To the extent Subjects were high in chronic interpersonal stress at baseline, their leukocytes displayed greater increases in messenger ribonucleic acid (mRNA) for the proinflammatory transcription factor nuclear factor-kappa B (NF-kappa B) over the next 6 months. They also showed larger increases in mRNA for inhibitor Of kappa B, a molecule that sequesters NF-kappa B in the cytoplasm and minimizes its proinflammatory activities. Chronic interpersonal stress at baseline was unrelated to changes in biomarkers of systemic inflammation but was associated with increasingly pronounced interleukin-6 responses to lipopolysaccharide. These associations were independent of demographics, lifestyle variables, and depressive symptoms. Conclusions: These findings suggest that chronic interpersonal difficulties accentuate expression of pro- and anti-inflammatory signaling molecules. Although this process does not result in systemic inflammation under quiescent conditions, it does accentuate leukocytes' inflammatory response to microbial challenge. These dynamics may underlie the excess morbidity associated with social stress, particularly in inflammation-sensitive diseases like depression and atherosclerosis.
C1 [Miller, Gregory E.; Rohleder, Nicolas] Univ British Columbia, Dept Psychol, Vancouver, BC V6T 1Z4, Canada.
   [Cole, Steve W.] Univ Calif Los Angeles, Sch Med, Div Hematol Oncol, Los Angeles, CA 90024 USA.
   [Cole, Steve W.] Univ Calif Los Angeles, Inst Mol Biol, AIDS Inst, Los Angeles, CA 90024 USA.
   [Cole, Steve W.] Univ Calif Los Angeles, Jonsson Comprehens Canc Ctr, Los Angeles, CA 90024 USA.
   [Cole, Steve W.] Univ Calif Los Angeles, Norman Cousins Ctr, Los Angeles, CA USA.
C3 University of British Columbia; University of California System;
   University of California Los Angeles; University of California Los
   Angeles Medical Center; David Geffen School of Medicine at UCLA;
   University of California System; University of California Los Angeles;
   University of California System; University of California Los Angeles;
   UCLA Jonsson Comprehensive Cancer Center; University of California
   System; University of California Los Angeles
RP Miller, GE (corresponding author), Univ British Columbia, Dept Psychol, 2136 W Mall Ave, Vancouver, BC V6T 1Z4, Canada.
EM gemiller@psych.ubc.ca
RI Cole, Steve/KYO-7764-2024; Rohleder, Nicolas/N-7598-2013
OI Rohleder, Nicolas/0000-0003-2602-517X; Miller,
   Gregory/0000-0002-7217-1082
FU Canadian Institutes of Health Research; Michael Smith Foundation for
   Health Research; Heart and Stroke Foundation of Canada; National
   Alliance for Research on Depression and Schizophrenia; German Research
   Foundation
FX Supported by grants from the Canadian Institutes of Health Research, the
   Michael Smith Foundation for Health Research, the Heart and Stroke
   Foundation of Canada, the National Alliance for Research on Depression
   and Schizophrenia, and the German Research Foundation.
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NR 38
TC 166
Z9 195
U1 0
U2 21
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0033-3174
EI 1534-7796
J9 PSYCHOSOM MED
JI Psychosom. Med.
PD JAN
PY 2009
VL 71
IS 1
BP 57
EP 62
DI 10.1097/PSY.0b013e318190d7de
PG 6
WC Psychiatry; Psychology; Psychology, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry; Psychology
GA 395ZR
UT WOS:000262562500010
PM 19073750
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Saxena, V
   Pal, A
   Talukdar, S
   Gupta, R
AF Saxena, Vrinda
   Pal, Arghya
   Talukdar, S.
   Gupta, Ravi
TI Relationship of obstructive sleep apnea with major depressive disorder
   and development of metabolic syndrome
SO INDIAN JOURNAL OF PSYCHIATRY
LA English
DT Article
DE Antidepressants; fluoxetine units; major depressive disorder; metabolic
   syndrome; obstructive sleep apnea
ID ANTIDEPRESSANTS; ABNORMALITIES; PREVALENCE; ANXIETY; RISK
AB Objective: Major depressive disorder (MDD) is often linked with a number of coexisting disorders with a relation that is poorly understood. The aim of this study was to find out the role of obstructive sleep apnea (OSA) in metabolic syndrome (MS) in subjects with MDD and to develop a model for factors leading to MS. Methods: It was a cross-sectional study conducted on 119 subjects. They were evaluated on sociodemographic and clinical parameters, Berlin questionnaire, and Quick Inventory of Depressive Symptomatology. Comparisons were made using appropriate statistics. Binary logistic regression was used to find out the role of clinical parameters in the development of MS. Results: A total of 34% with MDD had a high risk of developing OSA while 19% had metabolic syndrome. Among all clinical variables, antidepressant exposure in terms of total fluoxetine units, duration of treatment, and risk of developing OSA was found to be significantly more in patients with MS. A higher risk of OSA was found to have a higher likelihood to cause MS in patients with MDD. Conclusion: There is a high risk of MS and OSA in subjects with MDD. The increased risk of MS is contributed by an increased risk of developing OSA among patients with MDD. Cross-sectional design and limited generalizability are the major limitations of this study.
C1 [Saxena, Vrinda; Pal, Arghya; Talukdar, S.] Himalayan Inst Med Sci, Dept Psychiat, Dehra Dun, Uttarakhand, India.
   [Gupta, Ravi] All India Inst Med Sci, Dept Psychiat & Div Sleep Med, Rishikesh, Uttarakhand, India.
C3 All India Institute of Medical Sciences (AIIMS) Rishikesh
RP Saxena, V (corresponding author), Himalayan Inst Med Sci, Dept Psychiat, Dehra Dun, Uttarakhand, India.
EM Vrinda9sep@gmail.com
RI Pal, Arghya/AAL-1064-2021; Gupta, Ravi/D-1009-2011
OI Pal, Arghya/0000-0002-5887-1971; Gupta, Ravi/0000-0003-2583-563X
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   Wichniak A, 2017, CURR PSYCHIAT REP, V19, DOI 10.1007/s11920-017-0816-4
NR 28
TC 2
Z9 2
U1 0
U2 1
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, Maharashtra, INDIA
SN 0019-5545
EI 1998-3794
J9 INDIAN J PSYCHIAT
JI Indian J. Psychiatry
PD SEP-OCT
PY 2022
VL 64
IS 5
BP 505
EP 509
DI 10.4103/indianjpsychiatry.indianjpsychiatry_797_21
PG 5
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA N6GD9
UT WOS:001037964800008
PM 36458080
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Nocente, R
   Gentiloni, N
   Cremonini, F
   Giorgi, A
   Serricchio, M
   Santoliquido, A
   Gasbarrini, G
   Gasbarrini, A
AF Nocente, R
   Gentiloni, N
   Cremonini, F
   Giorgi, A
   Serricchio, M
   Santoliquido, A
   Gasbarrini, G
   Gasbarrini, A
TI Resolution of syndrome X after eradication of virulent CagA-positive
   Helicobacter pylori
SO SOUTHERN MEDICAL JOURNAL
LA English
DT Article
ID ISCHEMIC-HEART-DISEASE; INFECTION; ASSOCIATION
AB A 42-year-old man with chest pain was found to have ST depression in leads V-1 through V-4 The coronary arteries appeared normal on angiography. Positive results of ventricular pacing and acetylcholine test led to a diagnosis of syndrome X. Other studies revealed gastritis due to CagA-positive Helicobacter pylori. Classic therapy for angina did not resolve chest pain, but eradication of H pylori led to disappearance of symptoms and negative test results.
C1 Catholic Univ, Gemelli Hosp, Dept Internal Med, I-00168 Rome, Italy.
   Catholic Univ, Gemelli Hosp, Dept Angiol, I-00168 Rome, Italy.
C3 Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli;
   Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli
RP Gasbarrini, A (corresponding author), Catholic Univ, Gemelli Hosp, Dept Internal Med, Largo Gemelli 8, I-00168 Rome, Italy.
RI Gasbarrini, Antonio/AAB-8487-2019
OI santoliquido, angelo/0000-0003-1539-4017; Gasbarrini,
   Antonio/0000-0002-6230-1779
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NR 12
TC 11
Z9 12
U1 0
U2 1
PU SOUTHERN MEDICAL ASSN
PI BIRMINGHAM
PA 35 LAKESHORE DR PO BOX 190088, BIRMINGHAM, AL 35219 USA
SN 0038-4348
J9 SOUTHERN MED J
JI South.Med.J.
PD OCT
PY 2000
VL 93
IS 10
BP 1022
EP 1023
PG 2
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 368PZ
UT WOS:000090127800016
PM 11147468
DA 2025-06-11
ER

PT J
AU Todosenko, N
   Khaziakhmatova, O
   Malashchenko, V
   Yurova, K
   Bograya, M
   Beletskaya, M
   Vulf, M
   Gazatova, N
   Litvinova, L
AF Todosenko, Natalia
   Khaziakhmatova, Olga
   Malashchenko, Vladimir
   Yurova, Kristina
   Bograya, Maria
   Beletskaya, Maria
   Vulf, Maria
   Gazatova, Natalia
   Litvinova, Larisa
TI Mitochondrial Dysfunction Associated with mtDNA in Metabolic Syndrome
   and Obesity
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE metabolic syndrome; obesity; mitochondrial dysfunction; mtDNA;
   mitochondrial protease Lonp1
ID DNA COPY NUMBER; UNFOLDED PROTEIN RESPONSE; HUMAN LON PROTEASE;
   GENE-EXPRESSION; INDUCED INFLAMMATION; NLRP3 INFLAMMASOME;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; OXIDASE SUBUNITS; DOWN-REGULATION
AB Metabolic syndrome (MetS) is a precursor to the major health diseases associated with high mortality in industrialized countries: cardiovascular disease and diabetes. An important component of the pathogenesis of the metabolic syndrome is mitochondrial dysfunction, which is associated with tissue hypoxia, disruption of mitochondrial integrity, increased production of reactive oxygen species, and a decrease in ATP, leading to a chronic inflammatory state that affects tissues and organ systems. The mitochondrial AAA + protease Lon (Lonp1) has a broad spectrum of activities. In addition to its classical function (degradation of misfolded or damaged proteins), enzymatic activity (proteolysis, chaperone activity, mitochondrial DNA (mtDNA)binding) has been demonstrated. At the same time, the spectrum of Lonp1 activity extends to the regulation of cellular processes inside mitochondria, as well as outside mitochondria (nuclear localization). This mitochondrial protease with enzymatic activity may be a promising molecular target for the development of targeted therapy for MetS and its components. The aim of this review is to elucidate the role of mtDNA in the pathogenesis of metabolic syndrome and its components as a key component of mitochondrial dysfunction and to describe the promising and little-studied AAA + LonP1 protease as a potential target in metabolic disorders.
C1 [Todosenko, Natalia; Khaziakhmatova, Olga; Malashchenko, Vladimir; Yurova, Kristina; Bograya, Maria; Beletskaya, Maria; Vulf, Maria; Gazatova, Natalia; Litvinova, Larisa] Immanuel Kant Baltic Fed Univ, Ctr Immunol & Cellular Biotechnol, Kaliningrad 236001, Russia.
   [Litvinova, Larisa] Siberian State Med Univ, Lab Cellular & Microfluid Technol, Tomsk 634050, Russia.
C3 Immanuel Kant Baltic Federal University; Siberian State Medical
   University
RP Litvinova, L (corresponding author), Immanuel Kant Baltic Fed Univ, Ctr Immunol & Cellular Biotechnol, Kaliningrad 236001, Russia.; Litvinova, L (corresponding author), Siberian State Med Univ, Lab Cellular & Microfluid Technol, Tomsk 634050, Russia.
EM tod_89@mail.ru; olga_khaziakhmatova@mail.ru; vlmalashchenko@kantiana.ru;
   kristina_kofanova@mail.ru; mbograya@mail.ru; mariyabel@bk.ru;
   mary-jean@yandex.ru; n_gazatova@mail.ru; larisalitvinova@yandex.ru
RI Malashchenko, Vladimir/F-8974-2017; Bograya, Maria/JTS-7992-2023;
   Yurova, Kristina/F-7614-2017; Khaziakhmatova, Olga/F-7767-2017; Vulf,
   Maria/E-4926-2017; Litvinova, Larisa/A-9672-2014; Todosenko,
   Natalia/P-6176-2017
OI Vulf, Maria/0000-0002-4989-045X; Litvinova, Larisa/0000-0001-5231-6910;
   Bograya, Maria/0000-0002-4543-7850; Todosenko,
   Natalia/0000-0001-7468-4861
FU Russian Science Foundation [23-15-00061]
FX This research was funded by Russian Science Foundation (project No.
   23-15-00061).
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NR 169
TC 16
Z9 16
U1 2
U2 15
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD AUG
PY 2023
VL 24
IS 15
AR 12012
DI 10.3390/ijms241512012
PG 20
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA O7JM7
UT WOS:001045529200001
PM 37569389
OA gold
DA 2025-06-11
ER

PT J
AU Shirzadi, AA
   Ghaemi, SN
AF Shirzadi, Arshia A.
   Ghaemi, S. Nassir
TI Side effects of atypical antipsychotics: Extrapyramidal symptoms and the
   metabolic syndrome
SO HARVARD REVIEW OF PSYCHIATRY
LA English
DT Review
DE antipsychotic agents; diabetes mellitus; dyslipidemia; extrapyramidal
   symptoms; hypercholesterolemia; metabolic syndrome; obesity; side
   effects
ID INDUCED WEIGHT-GAIN; BODY-MASS INDEX; TARDIVE-DYSKINESIA; DOUBLE-BLIND;
   DIABETES-MELLITUS; EXCESS MORTALITY; PSYCHIATRIC-PATIENTS; TERM
   TREATMENT; TOLERANCE-TEST; SCHIZOPHRENIA
AB In this article we examine the two major classes of side effects with atypical antipsychotics: extrapyramidal symptoms (EPS) and the metabolic syndrome (the triad of diabetes, dyslipidemia, and hypertension, with associated obesity). We conclude that atypical antipsychotics continue to have notable risks of EPS, particularly akathisia, and that these agents also appear to increase the risk of the metabolic syndrome, though this effect seems most marked with clozapine and olanzapine. Novel conclusions based on this review are as follows: we provide a classification scheme based on low versus high D2 binding affinity (which is, to our knowledge, a new means of classifying atypical antipsychotics); we emphasize that the akathisia risk is likely equal among agents and that tardive dyskinesia is an early, and not late, risk in treatment (a common misconception); we make the methodological point that in randomized clinical trials, there is a high risk of false-negatives regarding side effects; we raise the issue of confounding bias in epidemiological studies of metabolic syndrome; and we stress the need to compare side effects in the same studies and not different studies. Future prospective observational cohort studies must target side effects and be designed to collect and analyze data on confounding factors.
C1 Emory Univ, Sch Med, Atlanta, GA 30322 USA.
   Harvard Univ, Shore Psychiat Program, Brockton, MA USA.
   Emory Univ, Sch Med, Dept Psychiat & Behav Sci, Atlanta, GA USA.
   Emory Univ, Sch Med, Bipolar Disorder Res Program, Atlanta, GA USA.
C3 Emory University; Harvard University; Emory University; Emory University
RP Ghaemi, SN (corresponding author), Emory Univ, Sch Med, 1365 Clifton Rd,Bldg B,Suite 6100, Atlanta, GA 30322 USA.
EM nghaemi@emory.edu
RI Ghaemi, Nassir/J-4934-2013
OI Ghaemi, Seyyed Nassir/0000-0001-9259-0885
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NR 121
TC 88
Z9 103
U1 0
U2 23
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1067-3229
EI 1465-7309
J9 HARVARD REV PSYCHIAT
JI Harv. Rev. Psychiatr.
PD MAY-JUN
PY 2006
VL 14
IS 3
BP 152
EP 164
DI 10.1080/10673220600748486
PG 13
WC Psychiatry
WE Social Science Citation Index (SSCI)
SC Psychiatry
GA 058XH
UT WOS:000238697400003
PM 16787887
DA 2025-06-11
ER

PT J
AU Alla, C
   Ali, A
   Mehiou, A
   Salhi, Y
   Bouanani, N
   Legssyer, A
   Ziyyat, A
AF Alla, Chaimae
   Ali, Amanat
   Mehiou, Afaf
   Salhi, Youssra
   Bouanani, Nourelhouda
   Legssyer, Abdelkhaleq
   Ziyyat, Abderrahim
TI Phytochemical Composition of Ziziphus lotus (L.) Lam and Its
   Impact on the Metabolic Syndrome: A Review
SO ADVANCES IN PHARMACOLOGICAL AND PHARMACEUTICAL SCIENCES
LA English
DT Review
DE diabetes; hypertension; metabolic syndrome; obesity and dyslipidemia;
   polyphenols; Ziziphus lotus (L.)
ID MEDICINAL-PLANTS; ZIZYPHUS-LOTUS; ETHNOPHARMACOLOGICAL SURVEY;
   RESVERATROL SUPPLEMENTATION; OXIDATIVE STRESS; FAT DIET; CYCLOPEPTIDE
   ALKALOIDS; ETHNOBOTANICAL SURVEY; ENDOTHELIAL DYSFUNCTION; TRADITIONAL
   TREATMENT
AB The long-term pathological state known as metabolic syndrome is characterized by hypertension, insulin resistance diabetes, abdominal obesity, and hyperlipidemia. Seeking healthcare strategies with fewer side effects, such as herbal remedies, is preferable in terms of mitigating the negative consequences of synthetic medications. Ziziphus lotus (L.) (Rhamnaceae) or wild jujube, commonly known as "Sedra," is one of the best choices as it contains a variety of phytochemicals and biologically active compounds. Several flavonoids and stilbenes have been recognized as the primary bioactive components in wild jujube, including rutin, hyperin, isoquercitrin, and resveratrol. These polyphenols are pharmacologically active and have broad-spectrum beneficial effects for reducing the risk factors associated with metabolic syndrome. They exhibit antioxidant and anti-inflammatory properties, regulate lipid metabolism, and possess antiobesity, antihypertensive, and antidiabetic characteristics. However, there are certain limitations to their therapeutic application, such as low bioavailability. Various strategies have been proposed to enhance their pharmacokinetic profile and therapeutic potential for future use. The main goal of this review is to explore the underlying mechanisms related to the therapeutic effects of wild jujube and its active compounds in the treatment and prevention of metabolic syndrome.
C1 [Alla, Chaimae; Ali, Amanat; Mehiou, Afaf; Salhi, Youssra; Bouanani, Nourelhouda; Legssyer, Abdelkhaleq; Ziyyat, Abderrahim] Univ Mohammed First, Fac Sci, Dept Biol, Lab Bioresources Biotechnol Ethnopharmacol & Hlth, Oujda, Morocco.
C3 Mohammed First University of Oujda
RP Ziyyat, A (corresponding author), Univ Mohammed First, Fac Sci, Dept Biol, Lab Bioresources Biotechnol Ethnopharmacol & Hlth, Oujda, Morocco.
EM ar.ziyyat@ump.ac.ma
RI ZIYYAT, Abderrahim/LMN-4853-2024
OI Ziyyat, Abderrahim/0000-0001-6384-2537
FU Centre National pour la Recherche Scientifique et Technique; CNRST;
   Ministry of Higher Education; National Agency of Aromatic [2VPMA
   2020/5]; Presidency of the Mohammed First University; Faculty of
   Sciences of Oujda
FX We express our utmost gratitude to the CNRST, the Ministry of Higher
   Education, the National Agency of Aromatic and Medicinal Plants of
   Taounate, and the Presidency of the Mohammed First University (Project
   2VPMA 2020/5) for their financial support (Project 2VPMA 2020/5). We
   also thank the Faculty of Sciences of Oujda for the logistical and
   financial support. At last, we thank Pr. Elachouri Mostafa from the
   biology department (Faculty of Sciences of Oujda) for allowing us to use
   three photos of Z. lotus that he took in the region of Abbou Lakhal near
   Figuig City (Morocco).
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NR 281
TC 0
Z9 0
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2633-4682
EI 2633-4690
J9 ADV PHARM PHARM SCI
JI Adv. Pharm. Pharm. Sci.
PY 2025
VL 2025
IS 1
AR 8276090
DI 10.1155/adpp/8276090
PG 28
WC Pharmacology & Pharmacy
WE Emerging Sources Citation Index (ESCI)
SC Pharmacology & Pharmacy
GA Y3U2U
UT WOS:001431409400001
PM 40035065
OA gold
DA 2025-06-11
ER

PT J
AU Pereira, CD
   Severo, M
   Araújo, JR
   Guimaraes, JT
   Pestana, D
   Santos, A
   Ferreira, R
   Ascensao, A
   Magalhaes, J
   Azevedo, I
   Monteiro, R
   Martins, MJ
AF Pereira, Cidalia Dionisio
   Severo, Milton
   Araujo, Joao Ricardo
   Guimaraes, Joao Tiago
   Pestana, Diogo
   Santos, Alejandro
   Ferreira, Rita
   Ascensao, Antonio
   Magalhaes, Jose
   Azevedo, Isabel
   Monteiro, Rosario
   Martins, Maria Joao
TI Relevance of a Hypersaline Sodium-Rich Naturally Sparkling Mineral Water
   to the Protection against Metabolic Syndrome Induction in Fructose-Fed
   Sprague-Dawley Rats: A Biochemical, Metabolic, and Redox Approach
SO INTERNATIONAL JOURNAL OF ENDOCRINOLOGY
LA English
DT Article
ID INSULIN-RESISTANCE; OXIDATIVE STRESS; INDUCED HYPERTENSION; MELATONIN;
   ALDOSTERONE; MAGNESIUM; EXTRACT; SYSTEM; MODEL; DYSFUNCTION
AB The Metabolic Syndrome increases the risk for atherosclerotic cardiovascular disease and type 2 Diabetes Mellitus. Increased fructose consumption and/or mineral deficiency have been associated with Metabolic Syndrome development. This study aimed to investigate the effects of 8 weeks consumption of a hypersaline sodium-rich naturally sparkling mineral water on 10% fructose-fed Sprague-Dawley rats (Metabolic Syndrome animal model). The ingestion of the mineral water (rich in sodium bicarbonate and with higher potassium, calcium, and magnesium content than the tap water used as control) reduced/prevented not only the fructose-induced increase of heart rate, plasma triacylglycerols, insulin and leptin levels, hepatic catalase activity, and organ weight to body weight ratios (for liver and both kidneys) but also the decrease of hepatic glutathione peroxidase activity and oxidized glutathione content. This mineral-rich water seems to have potential to prevent Metabolic Syndrome induction by fructose. We hypothesize that its regular intake in the context of modern diets, which have a general acidic character interfering with mineral homeostasis and are poor in micronutrients, namely potassium, calcium, and magnesium, could add surplus value and attenuate imbalances, thus contributing to metabolic and redox health and, consequently, decreasing the risk for atherosclerotic cardiovascular disease.
C1 [Pereira, Cidalia Dionisio; Araujo, Joao Ricardo; Guimaraes, Joao Tiago; Pestana, Diogo; Azevedo, Isabel; Monteiro, Rosario; Martins, Maria Joao] Univ Porto, Fac Med, Dept Biochem U38 FCT, P-4200319 Oporto, Portugal.
   [Severo, Milton] Univ Porto, Dept Clin Epidemiol Predict Med & Publ Hlth, Fac Med, P-4200319 Oporto, Portugal.
   [Guimaraes, Joao Tiago] EPE, Sao Joao Hosp Ctr, Dept Clin Pathol, P-4200319 Oporto, Portugal.
   [Santos, Alejandro] Univ Porto, Fac Nutr & Food Sci, P-4200465 Oporto, Portugal.
   [Ferreira, Rita] Univ Aveiro, Dept Chem, Mass Spectrometry Ctr, QOPNA, P-3810193 Aveiro, Portugal.
   [Ascensao, Antonio; Magalhaes, Jose] Univ Porto, Fac Sport, Res Ctr Phys Activ, CIAFEL, P-4200450 Oporto, Portugal.
C3 Universidade do Porto; Universidade do Porto; Sao Joao Hospital;
   Universidade do Porto; Universidade de Aveiro; Universidade do Porto
RP Martins, MJ (corresponding author), Univ Porto, Fac Med, Dept Biochem U38 FCT, P-4200319 Oporto, Portugal.
EM mmartins@med.up.pt
RI Araújo, João/GRY-7522-2022; Monteiro, Rosário/R-1387-2018; Santos,
   Alejandro/L-2658-2013; Martins, Maria João/ABC-8271-2021; Severo,
   Milton/I-3497-2012; Pereira, Cidalia Almeida/GPP-6411-2022; Ferreira,
   Rita/C-4020-2014; Guimaraes, Joao Tiago/T-3079-2017; Ascensao,
   Antonio/I-6171-2013; Magalhaes, Jose/B-6991-2009
OI Severo, Milton/0000-0002-5787-4871; Santos,
   Alejandro/0000-0003-0706-5301; Araujo, Joao Ricardo/0000-0003-2491-1047;
   Monteiro, Rosario/0000-0003-1552-5507; Pereira, Cidalia
   Almeida/0000-0001-9934-9648; Ferreira, Rita/0000-0002-6872-4051;
   Martins, Maria Joao/0000-0002-3560-3261; Pestana,
   Diogo/0000-0001-6332-7914; Guimaraes, Joao Tiago/0000-0003-4836-6311;
   Ascensao, Antonio/0000-0001-5269-0857; Magalhaes,
   Jose/0000-0003-4808-8374
FU FCT (Fundacao para a Ciencia e Tecnologia) [PEst-OE/SAU/UI0038/2011];
   Centro de Farmacologia e Biopatalogia Quimica [U38/FCT]; Faculty of
   Medicine; University of Porto; Department of Biochemistry, Faculty
   ofMedicine; Fundo Social Europeu, Programa Operacional Potencial Humano
   da UE [SFRH/BDE/33798/2009]; Unicer Bebidas, SA, Portugal; Fundação para
   a Ciência e a Tecnologia [SFRH/BDE/33798/2009, PEst-OE/SAU/UI0038/2011]
   Funding Source: FCT
FX The authors kindly thank Unicer Bebidas, SA, for providing Pedras
   Salgadas, and Marco Boscaro (DSI) and Delphine Bouard (Charles River
   Laboratories) for the helpful advices regarding the use of the telemetry
   software and the handling of the implanted Sprague-Dawley rats,
   respectively. This work was supported by FCT (Fundacao para a Ciencia e
   Tecnologia, PEst-OE/SAU/UI0038/2011) through the Centro de Farmacologia
   e Biopatalogia Quimica (U38/FCT), Faculty of Medicine, University of
   Porto, which integrates the Department of Biochemistry, Faculty
   ofMedicine, University of Porto. Additional funding was provided by FCT
   through the Fundo Social Europeu, Programa Operacional Potencial Humano
   da UE (SFRH/BDE/33798/2009), and by Unicer Bebidas, SA, Portugal.
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NR 68
TC 30
Z9 31
U1 0
U2 21
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1687-8337
EI 1687-8345
J9 INT J ENDOCRINOL
JI Int. J. Endocrinol.
PY 2014
VL 2014
AR 384583
DI 10.1155/2014/384583
PG 17
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA AA8AH
UT WOS:000331317500001
PM 24672546
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Michels, N
   Sioen, I
   Schraven, K
   De Decker, A
   van Aart, C
   De Henauw, S
AF Michels, Nathalie
   Sioen, Isabelle
   Schraven, Kirsten
   De Decker, Annelies
   van Aart, Carola
   De Henauw, Stefaan
TI Children's cortisol and externalizing stress symptoms are predictors of
   adiponectin evolution over two years
SO BIOLOGICAL PSYCHOLOGY
LA English
DT Article
DE Adiponectin; Cortisol; Emotions; Conduct problems; Children;
   Longitudinal
ID CIRCULATING ADIPONECTIN; INSULIN SENSITIVITY; PLASMA ADIPONECTIN;
   BODY-COMPOSITION; ADIPOSITY; QUESTIONNAIRE; LEPTIN; GLUCOCORTICOIDS;
   PREMENOPAUSAL; ASSOCIATION
AB Background: Adiponectin is an anti-inflammatory, insulin-sensitizing and energy-regulating adipocytokine. Consequently, the link between psychosocial stress and inflammatory diseases like the metabolic syndrome might be partially explained by lower adiponectin levels in stress. Nevertheless, the stress-adiponectin association has seldom been tested and no clarity exists about the directionality.
   Methods: In the Belgian ChiBS study, serum adiponectin and stress levels were measured in 348 children (5-10y) at baseline and in 168 of them after 2-year follow-up. Psychosocial stress was reported with the Strengths and Difficulties Questionnaire (parental report on emotional, peer, and conduct problems), negative emotions (anger, sadness, anxiety) and negative events. In addition, salivary cortisol diurnal patterns were available from 2 days with each 4 samples. Longitudinal linear regression analyses were performed including step-wise adjustment for age, sex, socio-economic status, body fat%, physical activity and snack frequency.
   Results: Despite some positive cross-sectional associations, high daily cortisol output (beta = -0.285), anger (beta = -0.233) and conduct problems (beta = -0.182) were associated with less adiponectin increase over time, in most cases independent of the tested confounders. The other directionality was not significant: no longitudinal prediction of stress by adiponectin.
   Conclusion: In healthy children, daily cortisol output and externalizing stress symptoms were negative predictors of adiponectin evolution. These findings highlight the health-compromising effects of psychosocial stress.
C1 [Michels, Nathalie; Sioen, Isabelle; Schraven, Kirsten; De Decker, Annelies; van Aart, Carola; De Henauw, Stefaan] Univ Ghent, Dept Publ Hlth, Fac Med & Hlth Sci, Ghent, Belgium.
C3 Ghent University
RP Michels, N (corresponding author), Univ Ghent, De Pintelaan 185 4K3, B-9000 Ghent, Belgium.
EM Nathalie.michels@ugent.be
RI Michels, Nathalie/C-2819-2012
OI Michels, Nathalie/0000-0002-3069-7254
FU Fondation Louis Bonduelle; Research Foundation Flanders [1268314N];
   research council of Ghent University (Bijzonder Onderzoeksfonds)
FX The authors want to thank the participating children and their parents
   for their voluntary participation, and all fieldworkers for their
   efforts. Adiponectin laboratory analyses were financed by the
   unconditional Louis Bonduelle research award (Fondation Louis Bonduelle)
   and by Research Foundation Flanders1268314N. The study was financed by
   the research council of Ghent University (Bijzonder Onderzoeksfonds).
   This support did not result in a conflict of interest. We acknowledge
   the bimetra biobank UGent for storage of our samples.
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NR 52
TC 3
Z9 3
U1 0
U2 11
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0301-0511
EI 1873-6246
J9 BIOL PSYCHOL
JI Biol. Psychol.
PD JAN
PY 2018
VL 131
SI SI
BP 89
EP 95
DI 10.1016/j.biopsycho.2017.05.016
PG 7
WC Psychology, Biological; Behavioral Sciences; Psychology; Psychology,
   Experimental
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Behavioral Sciences
GA FW1VJ
UT WOS:000425087900010
PM 28578188
DA 2025-06-11
ER

PT J
AU Svensson, K
   Hagström, J
   Blomqvist, M
   Jormfeldt, H
AF Svensson, Kristina
   Hagstrom, Johanna
   Blomqvist, Marjut
   Jormfeldt, Henrika
TI "Waiting in the Wings"-Next-of-Kin's Experiences of Lifestyle
   Interventions for People with Schizophrenia
SO ISSUES IN MENTAL HEALTH NURSING
LA English
DT Article
ID SEVERE MENTAL-ILLNESS; QUALITATIVE CONTENT-ANALYSIS; WEIGHT-GAIN;
   CARDIOVASCULAR RISK; METABOLIC SYNDROME; HEALTH; PREVALENCE; MORTALITY;
   RELATIVES; RECOVERY
AB People with schizophrenia have an increased risk of experiencing physical ill health and thus risk premature death. It is important to gain knowledge about the next-of-kin's experiences of lifestyle interventions in order to increase the understanding of the development of health promotion. This study aimed to describe the experiences of next-of-kin of lifestyle interventions for people with schizophrenia. Ten next-of-kin to people diagnosed with schizophrenia were interviewed and content analysis was used to analyze the data. Three categories emerged in the analysis: Low prioritization of physical health, Patients' needs for motivational support and Next-of-kin's' limited and distant participation. Mental health nurses need a holistic view of human beings and to include the patients' physical health and the role of the family in their responsibilities. Further studies are needed that focus on the views of the next-of-kin and the staff from the mental health services about the care and support needs for promoting physical health in this patient group.
C1 [Svensson, Kristina; Hagstrom, Johanna] Reg Halland, Dept Psychiat, Psychiat Clin Varberg, Halmstad, Sweden.
   [Blomqvist, Marjut; Jormfeldt, Henrika] Halmstad Univ, Sch Hlth & Welf, SE-30118 Halmstad, Sweden.
C3 Halmstad University
RP Blomqvist, M (corresponding author), Halmstad Univ, Sch Hlth & Welf, SE-30118 Halmstad, Sweden.
EM marjut.blomqvist@hh.se
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NR 70
TC 1
Z9 1
U1 0
U2 5
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 0161-2840
EI 1096-4673
J9 ISSUES MENT HEALTH N
JI Issues Ment. Health Nurs.
PD SEP 1
PY 2020
VL 41
IS 9
BP 832
EP 839
DI 10.1080/01612840.2020.1731026
EA MAY 2020
PG 8
WC Nursing; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Psychiatry
GA NI5GH
UT WOS:000535350300001
PM 32421461
OA hybrid
DA 2025-06-11
ER

PT J
AU Cho, IY
   Chang, Y
   Sung, E
   Sohn, W
   Kang, JH
   Shin, H
   Ryu, S
AF Cho, In Young
   Chang, Yoosoo
   Sung, Eunju
   Sohn, Won
   Kang, Jae-Heon
   Shin, Hocheol
   Ryu, Seungho
TI Depressive symptoms and risk of liver-related mortality in individuals
   with hepatitis B virus infection: a cohort study
SO SCIENTIFIC REPORTS
LA English
DT Article
ID METABOLIC SYNDROME; HEPATOCELLULAR-CARCINOMA; PHYSICAL-ACTIVITY;
   IMMUNE-SYSTEM; CANCER-RISK; DISEASE; ASSOCIATION; HEALTH; METAANALYSIS;
   ANXIETY
AB The impact of depression on the risk of liver-related mortality in individuals with hepatitis B virus (HBV) infection remains unclear. We examined the association between depression, HBV infection, and liver-related mortality. A total of 342,998 Korean adults who underwent health examinations were followed for up to 7.8 years. Depressive symptoms were defined as a Center for Epidemiologic Studies-Depression score >= 16. Cox proportional hazard models were used to estimate adjusted hazard ratios (aHRs) and 95% confidence intervals (CIs). During 1,836,508 person-years of follow-up, 74 liver-related deaths and 54 liver cancer deaths were identified (liver-related mortality rate of 4.0 per 10(5) person-years and liver cancer mortality rate of 2.9 per 10(5) person-years). Subjects with depressive symptoms had an increased risk of liver-related mortality with a corresponding multivariable aHR of 2.00 (95% CI 1.10-3.63) compared to those without depressive symptoms. This association was more evident in HBsAg-positive participants with a corresponding multivariable aHR of 4.22 (95% CI 1.81-9.88) than HBsAg-negative participants (P for interaction by HBsAg positivity=0.036). A similar pattern was observed in relation to liver cancer mortality. In this large cohort, depressive symptoms were associated with an increased risk of liver-related mortality, with a stronger association in HBsAg-positive individuals.
C1 [Cho, In Young; Sung, Eunju; Kang, Jae-Heon; Shin, Hocheol] Sungkyunkwan Univ, Kangbuk Samsung Hosp, Dept Family Med, Sch Med, 29 Saemunan Ro, Seoul 03181, South Korea.
   [Chang, Yoosoo; Sung, Eunju; Shin, Hocheol; Ryu, Seungho] Sungkyunkwan Univ, Ctr Cohort Studies, Total Healthcare Ctr, Kangbuk Samsung Hosp,Sch Med, Seoul, South Korea.
   [Chang, Yoosoo; Ryu, Seungho] Sungkyunkwan Univ, Kangbuk Samsung Hosp, Dept Occupat & Environm Med, Sch Med, Samsung Main Bldg B2,250 Taepyung Ro 2ga, Seoul 04514, South Korea.
   [Chang, Yoosoo; Ryu, Seungho] Sungkyunkwan Univ, Dept Clin Res Design & Evaluat, SAIHST, Seoul, South Korea.
   [Sohn, Won] Sungkyunkwan Univ, Kangbuk Samsung Hosp, Div Gastroenterol, Dept Internal Med,Sch Med, Seoul, South Korea.
C3 Sungkyunkwan University (SKKU); Sungkyunkwan University (SKKU); Samsung
   Medical Center; Sungkyunkwan University (SKKU); Sungkyunkwan University
   (SKKU); Sungkyunkwan University (SKKU); Samsung Medical Center
RP Shin, H (corresponding author), Sungkyunkwan Univ, Kangbuk Samsung Hosp, Dept Family Med, Sch Med, 29 Saemunan Ro, Seoul 03181, South Korea.; Shin, H; Ryu, S (corresponding author), Sungkyunkwan Univ, Ctr Cohort Studies, Total Healthcare Ctr, Kangbuk Samsung Hosp,Sch Med, Seoul, South Korea.; Ryu, S (corresponding author), Sungkyunkwan Univ, Kangbuk Samsung Hosp, Dept Occupat & Environm Med, Sch Med, Samsung Main Bldg B2,250 Taepyung Ro 2ga, Seoul 04514, South Korea.; Ryu, S (corresponding author), Sungkyunkwan Univ, Dept Clin Res Design & Evaluat, SAIHST, Seoul, South Korea.
EM hcfm.shin@samsung.com; sh703.yoo@gmail.com
RI Kim, Il Young/LLK-4732-2024
OI Ryu, Seungho/0000-0002-3927-8646; Kang, Jae-Heon/0000-0002-5209-0824;
   Chang, Yoosoo/0000-0002-6945-9050
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NR 62
TC 7
Z9 7
U1 2
U2 14
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD NOV 30
PY 2020
VL 10
IS 1
AR 20812
DI 10.1038/s41598-020-77886-2
PG 10
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Science & Technology - Other Topics
GA PU3JP
UT WOS:000609201200011
PM 33257781
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Krittanawong, C
   Maitra, NS
   Khawaja, M
   Wang, Z
   Fogg, S
   Rozenkrantz, L
   Virani, SS
   Levin, M
   Storch, EA
   Tobler, PN
   Charney, DS
   Levine, GN
AF Krittanawong, Chayakrit
   Maitra, Neil Sagar
   Khawaja, Muzamil
   Wang, Zhen
   Fogg, Sonya
   Rozenkrantz, Liron
   Virani, Salim S.
   Levin, Morris
   Storch, Eric A.
   Tobler, Philippe N.
   Charney, Dennis S.
   Levine, Glenn N.
TI Association of pessimism with cardiovascular events and all-cause
   mortality
SO PROGRESS IN CARDIOVASCULAR DISEASES
LA English
DT Review
DE Pessimism; Cardiovascular disease; All-cause mortality; Systematic
   review; Meta-analysis
ID AMBULATORY BLOOD-PRESSURE; CELL-MEDIATED-IMMUNITY; DISPOSITIONAL
   OPTIMISM; TRAIT ANXIETY; OLDER MEN; STRESS; ATHEROSCLEROSIS;
   INTERVENTION; INFLAMMATION; GAZE
AB Poor psychological health is associated with Takotsubo cardiomyopathy, cardiac syndrome X, coronary microcir-culatory dysfunction, peripheral artery disease, or spontaneous coronary artery dissection. Data regarding pessi-mism, cardiovascular disease (CVD) events and mortality and all-cause mortality remained inconclusive. This systematic review and meta-analysis aim to provide an overview of the association between pessimism, CVD out-comes and mortality. A systematic search of electronic databases was conducted from inception through July 2022 for studies evaluating pessimism and adverse outcomes. A total of 17 studies published between 1966 and July 2022 met our inclusion criteria, for a total of 232,533 individuals. Pooled hazard ratios were calculated in random-effects meta-analyses. Based on pooled analysis of adjusted HRs, pessimism was associated with ad-justed HR of 1.13 (95% CI 1.07-1.19) for all-cause mortality with minimal heterogeneity (I2 = 28.5%). Based on pooled analysis of adjusted HRs, pessimism was associated with adjusted HR of 1.30 (95% CI 0.43-3.95) for CHD mortality, adjusted HR of 1.41 (95% CI 1.05-1.91) for CVD mortality, and adjusted HR of 1.43 (95% CI 0.64-3.16) for stroke. In conclusion, pessimism seems to be significantly associated with a higher risk for and poorer outcomes from CVD events than optimistic styles. There are genetic and other bases for these life ap-proaches, but behavioral, cognitive and meditative interventions can modify patients' level of pessimism, hope-fully leading to better medical outcomes. Testing this theory would yield highly useful and practical data for clinical care.(c) 2022 Elsevier Inc. All rights reserved.
C1 [Krittanawong, Chayakrit; Maitra, Neil Sagar; Khawaja, Muzamil; Virani, Salim S.; Levine, Glenn N.] Baylor Coll Med, Sect Cardiol, Houston, TX USA.
   [Wang, Zhen] Mayo Clin, Robert D & Patricia E Kern Ctr Sci Hlth Care Deli, Rochester, MN USA.
   [Wang, Zhen] Mayo Clin, Dept Hlth Sci Res, Div Hlth Care Policy & Res, Rochester, MN USA.
   [Fogg, Sonya] Texas Heart Inst, Lib & Learning Resource Ctr, Houston, TX USA.
   [Rozenkrantz, Liron] Bar Ilan Univ, Azrieli Fac Med, Safed, Israel.
   [Levin, Morris] Univ Calif San Francisco, Dept Neurol, San Francisco, CA USA.
   [Storch, Eric A.] Baylor Coll Med, Menninger Dept Psychiat & Behav Sci, Houston, TX USA.
   [Tobler, Philippe N.] Univ Zurich, Dept Econ, Lab Social & Neural Syst Res, Zurich, Switzerland.
   [Charney, Dennis S.] Icahn Sch Med Mt Sinai, Depress & Anxiety Ctr Discovery & Treatment, Dept Psychiat, New York, NY USA.
   [Krittanawong, Chayakrit] NYU Sch Med, Sect Cardiol, Cardiol Div, 550 First Ave, New York, NY 10016 USA.
C3 Baylor College of Medicine; Mayo Clinic; Mayo Clinic; Texas Heart
   Institute; Bar Ilan University; University of California System;
   University of California San Francisco; Baylor College of Medicine;
   University of Zurich; Icahn School of Medicine at Mount Sinai; New York
   University
RP Krittanawong, C (corresponding author), NYU Sch Med, Sect Cardiol, Cardiol Div, 550 First Ave, New York, NY 10016 USA.
EM Chayakrit.Krittanawong@nyulangone.org
RI Rozenkrantz, Liron/HJH-2002-2023; Virani, Salim/AAF-1432-2019; Storch,
   Eric/I-4935-2012; Fogg, Sonya/GRS-5892-2022
OI Fogg, Sonya/0000-0003-2097-1827; Rozenkrantz, Liron/0000-0002-6496-4592
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NR 61
TC 6
Z9 7
U1 1
U2 6
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0033-0620
EI 1873-1740
J9 PROG CARDIOVASC DIS
JI Prog. Cardiovasc. Dis.
PD JAN-FEB
PY 2023
VL 76
BP 91
EP 98
DI 10.1016/j.pcad.2022.11.018
EA MAR 2023
PG 8
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA A6OG7
UT WOS:000956290000001
PM 36462555
DA 2025-06-11
ER

PT J
AU Angelico, F
   Del Ben, M
   Conti, R
   Francioso, S
   Feole, K
   Fiorello, S
   Cavallo, MG
   Zalunardo, B
   Lirussi, F
   Alessandri, C
   Violi, F
AF Angelico, F
   Del Ben, M
   Conti, R
   Francioso, S
   Feole, K
   Fiorello, S
   Cavallo, MG
   Zalunardo, B
   Lirussi, F
   Alessandri, C
   Violi, F
TI Insulin resistance, the metabolic syndrome, and nonalcoholic fatty liver
   disease
SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Article
ID HOMEOSTASIS MODEL ASSESSMENT; ORAL GLUCOSE-TOLERANCE; PRACTICAL GUIDE;
   STEATOHEPATITIS; PREVALENCE; SPECTRUM; ORIGINS
AB Background/Aims: An association of nonalcoholic fatty liver disease with the insulin-resistant metabolic syndrome has been suggested. The aim of the study was to assess the association of fatty liver to different degrees of insulin resistance and secretion.
   Methods and Results: The study was performed in 308 alcohol- and virus-negative consecutive patients attending a metabolic clinic, who underwent a complete clinical and biochemical work-up including oral glucose tolerance test and routine liver ultrasonography. Steatosis was graded as absent/ mild, moderate, and severe.
   In nondiabetic subjects, a progressive ( P < 0.05) increase in mean homeostasis model of insulin resistance was recorded from the group without steatosis to the groups with mild/moderate and severe steatosis. Severe steatosis was associated with the clustering of the five clinical and biochemical features proposed for the clinical diagnosis of the metabolic syndrome.
   Subjects with the metabolic syndrome with a more pronounced insulin resistance had a higher prevalence of severe steatosis ( P < 0.01) compared with those with homeostasis model of insulin resistance below the median.
   Conclusions: The findings stress the heterogeneous presentation of patients with the metabolic syndrome when the diagnosis is based on the broad Adult Treatment Panel III clinical criteria and demonstrate that those who are more insulin resistant have a higher prevalence of severe steatosis.
C1 Univ Roma La Sapienza, Dept Expt Med & Pathol, Div Internal Med 4, I-00161 Rome, Italy.
   Univ Roma La Sapienza, Div Clin & Appl Med Therapy, I-00161 Rome, Italy.
   Univ Padua, Dept Med & Surg Sci, I-35100 Padua, Italy.
C3 Sapienza University Rome; Sapienza University Rome; University of Padua
RP Policlin Umberto 1, Div Internal Med 4, Via Antonio Nibby 8, I-00161 Rome, Italy.
EM Francesco.angelico@uniroma1.it
RI Lirussi, Frederic/AAM-8186-2020; Angelico, Francesco/AAB-6585-2020; Del
   Ben, Maria/AAE-7603-2020; Baroni, Marco Giorgio/AIA-6973-2022; Maurano,
   Francesco/H-6487-2013; Violi, Francesco/K-1509-2016
OI Violi, Francesco/0000-0002-6610-7068; cavallo, maria
   gisella/0000-0001-6630-8049
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NR 30
TC 216
Z9 239
U1 0
U2 5
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0021-972X
EI 1945-7197
J9 J CLIN ENDOCR METAB
JI J. Clin. Endocrinol. Metab.
PD MAR
PY 2005
VL 90
IS 3
BP 1578
EP 1582
DI 10.1210/jc.2004-1024
PG 5
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 904UQ
UT WOS:000227523600046
PM 15598693
OA Bronze
DA 2025-06-11
ER

PT J
AU Maes, M
   Jirakran, K
   Vasupanrajit, A
   Niu, MQ
   Zhou, B
   Tunvirachaisakul, C
AF Maes, Michael
   Jirakran, Ketsupar
   Vasupanrajit, Asara
   Niu, Mengqi
   Zhou, Bo
   Tunvirachaisakul, Chavit
TI The recurrence of illness (ROI) index is a key factor in major
   depression that indicates increasing immune-linked neurotoxicity and
   vulnerability to suicidal behaviors
SO PSYCHIATRY RESEARCH
LA English
DT Article
DE Depression; Staging; Neuroimmune; Immune-linked neurotoxicity;
   Atherogenicity; Biomarkers
ID QUALITY-OF-LIFE; CHILDHOOD TRAUMA; BIPOLAR DISORDER; PERIPHERAL
   INFLAMMATION; METABOLIC SYNDROME; FAMILY-HISTORY; RATING-SCALE;
   RISK-FACTORS; ASSOCIATION; SEVERITY
AB In this study, we aimed to investigate the associations between the recurrence of illness (ROI) and biomarkers related to an activated immune network, immune-linked neurotoxicity (INT), and a combined INT and atherogenicity index (METAMMUNE). The study involved 67 healthy controls and 66 outpatient MDD (OMDD) participants. We utilized a Multiplex method to measure 48 cytokines and examined INT and METAMMUNE composite scores in association with different ROI indices. Our findings revealed that a ROI index was successfully created by extracting a validated principal component, from the physician-rated or self-declared number of depressive episodes, the frequency of lifetime suicidal ideation and attempts. ROI was significantly associated with INT and METAMMUNE indices, neuroticism, lifetime and current suicidal behaviors, and the phenome. Our analysis also revealed that a significant portion of the variance in the OMDD phenome, which includes current suicidal behaviors, anxiety, and depression, can be accounted for by the regression on INT, ROI, and emotional neglect and abuse. A validated latent construct was successfully extracted from the three ROI components, INT and METAMMUNE indices. The results indicate that increasing ROI indicates heightened immune-metabolic abnormalities, increased risk of suicidal behaviors, and elevated severity of lifetime and current phenome features.
C1 [Maes, Michael; Niu, Mengqi; Zhou, Bo] Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Sichuan Prov Ctr Mental Hlth, Sch Med, Chengdu 610072, Peoples R China.
   [Maes, Michael; Niu, Mengqi; Zhou, Bo] Chinese Acad Med Sci, Key Lab Psychosomat Med, Chengdu 610072, Peoples R China.
   [Maes, Michael; Jirakran, Ketsupar; Vasupanrajit, Asara; Tunvirachaisakul, Chavit] Chulalongkorn Univ, Fac Med, Dept Psychiat, Bangkok, Thailand.
   [Maes, Michael; Vasupanrajit, Asara; Tunvirachaisakul, Chavit] Chulalongkorn Univ, Fac Med, Dept Psychiat, PhD Program Mental Hlth, Bangkok, Thailand.
   [Maes, Michael; Tunvirachaisakul, Chavit] Chulalongkorn Univ, Fac Med, Cognit Impairment & Dementia Res Unit, Bangkok, Thailand.
   [Maes, Michael] Chulalongkorn Univ, Fac Med, Cognit Fitness & Biopsychol Technol Res Unit, Bangkok, Thailand.
   [Maes, Michael] Med Univ Plovdiv, Dept Psychiat, Plovdiv, Bulgaria.
   [Maes, Michael] Med Univ Plovdiv, Res Inst, Plovdiv, Bulgaria.
   [Maes, Michael] Kyung Hee Univ, 26 Kyungheedae Ro, Seoul 02447, South Korea.
   [Maes, Michael] European Union NextGenerationEU, Strateg Res & Innovat Program Dev MU PLOVDIV SRIPD, Plovdiv, Bulgaria.
   [Maes, Michael] Chulalongkorn Univ, Fac Med, Ctr Excellence Maximizing Childrens Dev Potential, Dept Pediat, Bangkok, Thailand.
C3 Sichuan Provincial People's Hospital; University of Electronic Science &
   Technology of China; Chinese Academy of Medical Sciences - Peking Union
   Medical College; Chulalongkorn University; Chulalongkorn University;
   Chulalongkorn University; Chulalongkorn University; Medical University
   Plovdiv; Medical University Plovdiv; Kyung Hee University; Chulalongkorn
   University
RP Maes, M; Zhou, B (corresponding author), Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Sichuan Prov Ctr Mental Hlth, Sch Med, Chengdu 610072, Peoples R China.
EM 770552576@qq.com
RI Vasupanrajit, Asara/ABG-5437-2021; Maes, Michael/B-8546-2011; Niu,
   Mengqi/HOF-2248-2023
OI Stoyanov, Drozdstoy/0000-0002-9975-3680; Maes,
   Michael/0000-0002-2012-871X
FU Ratchadapiseksompotch Fund, Graduate Affairs, Faculty of Medicine,
   Chulalongkorn University [GA64/21]; CU Graduate School Thesis Grant;
   Chulalongkorn University Graduate Scholarship; Thailand Science
   research, and Innovation Fund Chulalongkorn University [HEA663000016];
   Sompoch Endowment Fund (Faculty of Medicine) MDCU [RA66/016]; Strategic
   Research and Innovation Program for the Development of MU-PLOVDIV-
   (SRIPD-MUP) , Creation of a network of research higher schools, National
   plan for recovery and sustainability, European Union-NextGenerationEU
   [BG-RRP-2.004-0007-Scy;01]
FX This work was supported by the Ratchadapiseksompotch Fund, Graduate
   Affairs, Faculty of Medicine, Chulalongkorn University (Grant number
   GA64/21) , a grant from CU Graduate School Thesis Grant, and
   Chulalongkorn University Graduate Scholarship to Commemorate the 72nd
   Anniversary of His Majesty King Bhumibol Adulyadej to KJ; the Thailand
   Science research, and Innovation Fund Chulalongkorn University
   (HEA663000016) , and a Sompoch Endowment Fund (Faculty of Medicine) MDCU
   (RA66/016) to MM, and Grant No BG-RRP-2.004-0007-& Scy;01, & Scy;01,
   Strategic Research and Innovation Program for the Development of
   MU-PLOVDIV- (SRIPD-MUP) , Creation of a network of research higher
   schools, National plan for recovery and sustainability, European
   Union-NextGenerationEU.
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NR 65
TC 1
Z9 1
U1 1
U2 2
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0165-1781
EI 1872-7123
J9 PSYCHIAT RES
JI Psychiatry Res.
PD SEP
PY 2024
VL 339
AR 116085
DI 10.1016/j.psychres.2024.116085
EA JUL 2024
PG 11
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA ZL9T6
UT WOS:001275579500001
PM 39032358
OA Green Submitted, hybrid
DA 2025-06-11
ER

PT J
AU Brietzke, E
   Mansur, RB
   Subramaniapillai, M
   Balanzá-Martínez, V
   Vinberg, M
   González-Pinto, A
   Rosenblat, JD
   Ho, R
   McIntyre, RS
AF Brietzke, Elisa
   Mansur, Rodrigo B.
   Subramaniapillai, Mehala
   Balanza-Martinez, Vicent
   Vinberg, Maj
   Gonzalez-Pinto, Ana
   Rosenblat, Joshua D.
   Ho, Roger
   McIntyre, Roger S.
TI Ketogenic diet as a metabolic therapy for mood disorders: Evidence and
   developments
SO NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
LA English
DT Review
DE Mood disorders; Major depressive disorders; Bipolar disorder; Metabolic
   syndrome; Ketogenic diet; Ketones
ID DOMAIN CRITERIA RDOC; BIPOLAR DISORDER; MITOCHONDRIAL BIOGENESIS;
   ANTIINFLAMMATORY AGENTS; CALORIE RESTRICTION; ENERGY-METABOLISM;
   OXIDATIVE STRESS; SELFISH BRAIN; DEPRESSION; TRIAL
AB Despite significant advances in pharmacological and non-pharmacological treatments, mood disorders remain a significant source of mental capital loss, with high rates of treatment resistance, requiring a coordinated effort in investigation and development of efficient, tolerable and accessible novel interventions. Ketogenic diet (KD) is a low-carb diet that substantially changes the energetic matrix of the body including the brain. It has been established as an effective anticonvulsant treatment, and more recently, the role of KD for mental disorders has been explored. Ketogenic diet has profound effects in multiple targets implicated in the pathophysiology of mood disorders, including but not limited to, glutamate/GABA transmission, monoamine levels, mitochondrial function and biogenesis, neurotrophism, oxidative stress, insulin dysfunction and inflammation. Preclinical studies, case reports and case series have demonstrated antidepressant and mood stabilizing effects of KD, however, to date, no clinical trials for depression or bipolar disorder have been conducted. Because of its potential pleiotropic benefits, KD should be considered as a promising intervention in research in mood disorder therapeutics, especially in treatment resistant presentations.
C1 [Brietzke, Elisa; Mansur, Rodrigo B.; Subramaniapillai, Mehala; Rosenblat, Joshua D.; McIntyre, Roger S.] Univ Toronto, UHN, MDPU, Toronto, ON, Canada.
   [Brietzke, Elisa] Fed Univ Sao Paulo Unifesp, Dept Psychiat, Sao Paulo, Brazil.
   [Balanza-Martinez, Vicent] Univ Valencia, Unitat Docent Psiquiat & Psicol Med,Valencia Unit, Unitat Docent Psiquiat & Psicol Med,Dept Med,Madr, Valencia Ctr Invest Biomed Red Salud CIBERSAM,Ins, Valencia, Spain.
   [Vinberg, Maj] Univ Copenhagen, Rigshosp, Psychiat Ctr Copenhagen, Copenhagen, Denmark.
   [Gonzalez-Pinto, Ana] EHU, CIBERSAM, Hosp Univ Alava Santiago, Vitoria, Spain.
   [Ho, Roger] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Psychol Med, Singapore, Singapore.
   [Ho, Roger] Natl Univ Hlth Syst, Dept Psychol Med, Singapore, Singapore.
   [McIntyre, Roger S.] BCDF, Toronto, ON, Canada.
C3 University of Toronto; University Health Network Toronto; Universidade
   Federal de Sao Paulo (UNIFESP); University of Valencia; Rigshospitalet;
   University of Copenhagen; Copenhagen University Hospital; CIBER - Centro
   de Investigacion Biomedica en Red; CIBERSAM; National University of
   Singapore; National University of Singapore
RP Brietzke, E (corresponding author), 399 Bathrust St,9th Floor,Main Pavil, Toronto, ON, Canada.
EM elisa.brietzke@unifesp.br
RI Mansur, Rodrigo/N-7131-2019; Brietzke, Elisa/G-9559-2012; Torres,
   Miguel/HZK-8113-2023; Ho, Roger/ABD-9061-2021; McIntyre,
   Roger/AAU-1000-2020; Balanzá-Martínez, Vicent/C-3073-2011;
   Vinberg/ABC-7493-2021; Ho, Roger/H-8714-2014
OI Rosenblat, Joshua/0000-0002-4773-2191; Vinberg, Maj/0000-0002-5982-1335;
   Gonzalez-Pinto, Ana Maria/0000-0002-2568-5179; Ho,
   Roger/0000-0001-9629-4493; Balanza-Martinez, Vicent/0000-0001-7772-7396
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NR 97
TC 112
Z9 114
U1 3
U2 78
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0149-7634
EI 1873-7528
J9 NEUROSCI BIOBEHAV R
JI Neurosci. Biobehav. Rev.
PD NOV
PY 2018
VL 94
BP 11
EP 16
DI 10.1016/j.neubiorev.2018.07.020
PG 6
WC Behavioral Sciences; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Behavioral Sciences; Neurosciences & Neurology
GA GX9CW
UT WOS:000448097100002
PM 30075165
DA 2025-06-11
ER

PT J
AU Su, WJ
   Peng, W
   Gong, H
   Liu, YZ
   Zhang, Y
   Lian, YJ
   Cao, ZY
   Wu, R
   Liu, LL
   Wang, B
   Wang, YX
   Jiang, CL
AF Su, Wen-Jun
   Peng, Wei
   Gong, Hong
   Liu, Yun-Zi
   Zhang, Yi
   Lian, Yong-Jie
   Cao, Zhi-Yong
   Wu, Ran
   Liu, Lin-Lin
   Wang, Bo
   Wang, Yun-Xia
   Jiang, Chun-Lei
TI Antidiabetic drug glyburide modulates depressive-like behavior comorbid
   with insulin resistance
SO JOURNAL OF NEUROINFLAMMATION
LA English
DT Article
DE Depression; Insulin resistance; Glyburide; NLRP3 inflammasome; Stress;
   Inflammation
ID NLRP3 INFLAMMASOME ACTIVATION; BETA-CELL; DIABETES-MELLITUS; MOUSE
   MODEL; STRESS; RISK; ACCUMULATION; CONTRIBUTES; DYSFUNCTION; MECHANISMS
AB Background: Abundant reports indicated that depression was often comorbid with type 2 diabetes and even metabolic syndrome. Considering they might share common biological origins, it was tentatively attributed to the chronic cytokine-mediated inflammatory response which was induced by dysregulation of HPA axis and overactivation of innate immunity. However, the exact mechanisms remain obscure. Herein, we mainly focused on the function of the NLRP3 inflammasome to investigate this issue.
   Methods: Male C57BL/6 mice were subjected to 12 weeks of chronic unpredictable mild stress (CUMS), some of which were injected with glyburide or fluoxetine. After CUMS procedure, behavioral and metabolic tests were carried out. In order to evaluate the systemic inflammation associated with inflammasome activation, IL-1 beta and inflammasome components in hippocampi and pancreases, as well as corticosterone and IL-1 beta in serum were detected separately. Moreover, immunostaining was performed to assess morphologic characteristics of pancreases.
   Results: In the present study, we found that 12 weeks' chronic stress resulted in depressive-like behavior comorbid with insulin resistance. Furthermore, antidiabetic drug glyburide, an inhibitor of the NLRP3 inflammasome, was discovered to be effective in preventing the experimental comorbidity. In brief, it improved behavioral performance, ameliorated insulin intolerance as well as insulin signaling in the hippocampus possibly through inhibiting NLRP3 inflammasome activation by suppressing the expression of TXNIP.
   Conclusions: All these evidence supported our hypothesis that chronic stress led to comorbidity of depressive-like behavior and insulin resistance via long-term mild inflammation. More importantly, based on the beneficial effects of blocking the activation of the NLRP3 inflammasome, we provided a potential therapeutic target for clinical comorbidity and a new strategy for management of both diabetes and depression.
C1 [Su, Wen-Jun; Peng, Wei; Gong, Hong; Liu, Yun-Zi; Lian, Yong-Jie; Cao, Zhi-Yong; Wu, Ran; Liu, Lin-Lin; Wang, Bo; Wang, Yun-Xia; Jiang, Chun-Lei] Second Mil Med Univ, Fac Psychol & Mental Hlth, Lab Stress Med, 800 Xiangyin Rd, Shanghai, Peoples R China.
   [Zhang, Yi] Second Mil Med Univ, Fac Psychol & Mental Hlth, Dept Psychiat, 800 Xiangyin Rd, Shanghai, Peoples R China.
   [Cao, Zhi-Yong] 102nd Hosp PLA, Dept Psychiat, 55 North Heping Rd, Changzhou, Peoples R China.
C3 Naval Medical University; Naval Medical University
RP Jiang, CL (corresponding author), Second Mil Med Univ, Fac Psychol & Mental Hlth, Lab Stress Med, 800 Xiangyin Rd, Shanghai, Peoples R China.
EM cljiang@vip.163.com
RI Peng, Wei/LPQ-0448-2024; Su, Wen-Jun/KPA-3786-2024; Gong,
   Hong/L-5566-2013
OI Su, Wen-Jun/0000-0002-2707-3600; Gong, Hong/0000-0003-4393-1078
FU National Natural Science Foundation of China [81571169, 31371200];
   Military Medical Research Project of PLA [AHJ16J001]
FX This study was supported by the National Natural Science Foundation of
   China (grant numbers 81571169, 31371200), and the Military Medical
   Research Project of PLA (grant number AHJ16J001).
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NR 75
TC 40
Z9 44
U1 0
U2 21
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1742-2094
J9 J NEUROINFLAMM
JI J. Neuroinflamm.
PD OCT 30
PY 2017
VL 14
AR 210
DI 10.1186/s12974-017-0985-4
PG 12
WC Immunology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Neurosciences & Neurology
GA FL1HK
UT WOS:000413965100001
PM 29084550
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Singh, S
   Bansal, A
   Singh, V
   Chopra, T
   Poddar, J
AF Singh, Sukhpal
   Bansal, Abhishek
   Singh, Vikramjeet
   Chopra, Tanya
   Poddar, Jit
TI Flavonoids, alkaloids and terpenoids: a new hope for the treatment of
   diabetes mellitus
SO JOURNAL OF DIABETES AND METABOLIC DISORDERS
LA English
DT Review
DE Diabetes mellitus; Hyperglycemia; Oxidative stress; Phytochemicals;
   Phenolic compounds
ID PANCREATIC BETA-CELLS; OXIDATIVE STRESS; MOMORDICA-CHARANTIA;
   INHIBITORY-ACTIVITY; INSULIN-RESISTANCE; ALPHA-GLUCOSIDASE; AUTOPHAGY;
   INFLAMMATION; HYPERGLYCEMIA; L.
AB Diabetes mellitus is a metabolic syndrome characterized by a hyperglycemic state and multi-organ failure. Millions of people worldwide are suffering from this deadly disease taking a hit on their pocket and mental health in the name of its treatment. Modern medical practices with new technological advancements and discoveries have made revolutionary changes in the treatment. But, unfortunately, Glucose-lowering drugs used have many accompanying effects such as chronic vascular disease, renal malfunction, liver disease and, many skin problems. These complications have made us think about alternative treatments for diabetes with minimum or no side effects. Nowadays, in addition to modern medicine, herbal treatment has been suggested to treat diabetes mellitus. These herbal medicines contain biological macromolecules such as flavonoids, Terpenoids, glycosides, and alkaloids, which show versatile anti-diabetic effects. These phytochemicals are generally considered safe, and naturally occurring compounds have a potential role in preventing or controlling diabetes mellitus. The underlying mechanism of their anti-diabetic effects includes improvement in insulin secretion, decrease in insulin resistance, enhanced liver glycogen synthesis, antioxidant and anti-inflammatory activities. In this review, we have focused on the mechanism of various phytochemicals targeting hyperglycemia and its underlying pathogenesis.
C1 [Singh, Sukhpal] Maharishi Markandeswar Deemed Univ, MM Inst Med Sci & Res, Dept Biochem & Cent Res Cell, Mullana 133207, Ambala, India.
   [Bansal, Abhishek] RAJOURI, Govt Med Coll, Dept Biochem, Rajouri 185135, Jammu & Kashmir, India.
   [Singh, Vikramjeet] Kalpana Chawla Govt Med Coll, Karnal, Haryana, India.
   [Chopra, Tanya] Maharishi Markandeshwar Deemed Univ, MM Inst Med Sci & Res, Dept Biochem & Cent Res Cell, Mullana 133207, Ambala, India.
   [Poddar, Jit] RG Kar Med Coll & Hosp, Dept Microbiol, Kolkata 700003, W Bengal, India.
C3 Maharishi Markandeshwar University; Maharishi Markandeshwar University;
   RG Kar Medical College & Hospital
RP Bansal, A (corresponding author), RAJOURI, Govt Med Coll, Dept Biochem, Rajouri 185135, Jammu & Kashmir, India.
EM sukhpal619@gmail.com; bansalabhishek99@gmail.com;
   vikramjeets1997@gmail.com; chopratanya08@gmail.com; poddar.jit@gmail.com
RI Chopra, Tanya/JSK-5922-2023; Bansal, Abhishek/AAR-3727-2020
OI Bansal, Abhishek/0000-0001-7895-5657
FU Maharishi Markandeswar (Deemed to be University)
FX The authors are thankful to the management of Maharishi Markandeswar
   (Deemed to be University) for their research support. Special thanks to
   Dr. Adesh K Saini (Professor, Department of Biotechnology, MMDU) and Dr.
   Divya Mittal (University Post-Doctoral Fellow, MMDU) for critically
   reviewing the manuscript.
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NR 78
TC 32
Z9 36
U1 4
U2 27
PU SPRINGER INT PUBL AG
PI CHAM
PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND
EI 2251-6581
J9 J DIABETES METAB DIS
JI J. Diabetes Metab. Disord.
PD JUN
PY 2022
VL 21
IS 1
BP 941
EP 950
DI 10.1007/s40200-021-00943-8
EA JAN 2022
PG 10
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA 1V2OI
UT WOS:000740208700001
PM 35673446
OA Green Published
DA 2025-06-11
ER

PT J
AU Rantanen, AT
   Korkeila, JJA
   Kautiainen, H
   Korhonen, PE
AF Rantanen, Ansa Talvikki
   Korkeila, Jyrki Jaakko Antero
   Kautiainen, Hannu
   Korhonen, Paivi Elina
TI Non-melancholic depressive symptoms increase risk for incident
   cardiovascular disease: A prospective study in a primary care population
   at risk for cardiovascular disease and type 2 diabetes
SO JOURNAL OF PSYCHOSOMATIC RESEARCH
LA English
DT Article
DE Beck's Depression Inventory; Cardiovascular disease; Depressive symptom
   subtypes; Melancholic; Non-melancholic; Risk
ID METABOLIC SYNDROME; BIDIRECTIONAL ASSOCIATION; ATYPICAL DEPRESSION;
   10-YEAR RISK; METAANALYSIS; SUBTYPES; RECOMMENDATIONS; NETHERLANDS;
   ANXIETY
AB Objective: To assess subtypes of depressive symptoms and their relationship with cardiovascular disease (CVD) morbidity among CVD risk persons.
   Methods: A prospective study of 2522 CVD risk persons was conducted. Non-melancholic and melancholic depressive symptoms were assessed by Beck's Depression Inventory. Data on incident CVD was gathered from a national register, after 8 years of follow-up.
   Results: At baseline, the prevalence of non-melancholic and melancholic depressive symptoms was 14.9% and 5.2%, respectively. A total of 18,413 person-years was followed up, and the incidence of CVD was 9.6% in non-depressive, 14.1% in non-melancholically depressive, and 13.0% in melancholically depressive subjects. When adjusted for age, gender, education, smoking, alcohol use, leisure-time physical activity, hypertension, and dyslipidemia, the incidence rate ratios (IRR) for CVD in subjects with non-melancholic and melancholic depressive symptoms compared to non-depressiveness were IRR 1.69 (95% CI: 1.23-2.31) and IRR 1.31 (95% CI: 0.75-2.26).
   Conclusion: Non-melancholic depressive symptoms seem to increase risk for incident CVD among CVD risk subjects. Considering non-melancholic depressive symptoms might be useful when treating subjects with other CVD risk factors.
C1 [Rantanen, Ansa Talvikki; Korhonen, Paivi Elina] Univ Turku, Dept Gen Practice, Turku, Finland.
   [Rantanen, Ansa Talvikki; Korkeila, Jyrki Jaakko Antero; Korhonen, Paivi Elina] Turku Univ Hosp, Turku, Finland.
   [Rantanen, Ansa Talvikki] Salo Hlth Ctr, Salo, Finland.
   [Korkeila, Jyrki Jaakko Antero] Univ Turku, Dept Psychiat, Turku, Finland.
   [Korkeila, Jyrki Jaakko Antero] Hosp Dist Satakunta, Dept Psychiat, Pori, Finland.
   [Kautiainen, Hannu] Folkhalsan Res Ctr, Helsinki, Finland.
   [Kautiainen, Hannu] Kuopio Univ Hosp, Unit Primary Hlth Care, Kuopio, Finland.
   [Korhonen, Paivi Elina] Cent Satakunta Hlth Federat Municipal, Harjavalta, Finland.
C3 University of Turku; University of Turku; University of Turku;
   Folkhalsan Research Center; Kuopio University Hospital; University of
   Eastern Finland; University of Eastern Finland Hospital
RP Rantanen, AT (corresponding author), ICT City, Gen Practice, Joukahaisenkatu 3-5A, Turku 20520, Finland.
EM atsipp@utu.fi
RI Rantanen, Ansa/HDM-6559-2022
OI Rantanen, Ansa/0000-0001-5639-4756
FU Central Satakunta Health Federation of Municipalities
FX This study was supported by the Central Satakunta Health Federation of
   Municipalities. The study funder played no role in the study.
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NR 49
TC 13
Z9 13
U1 0
U2 6
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-3999
EI 1879-1360
J9 J PSYCHOSOM RES
JI J. Psychosomat. Res.
PD FEB
PY 2020
VL 129
AR 109887
DI 10.1016/j.jpsychores.2019.109887
PG 7
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA KF1II
UT WOS:000509003700004
PM 31837539
DA 2025-06-11
ER

PT J
AU ElBatsh, MM
AF ElBatsh, Maha Mohamed
TI Antidepressant-like effect of simvastatin in diabetic rats
SO CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
LA English
DT Article
DE simvastatin; depression; diabetes; forced swim test; serotonin;
   corticosterone
ID HIGH-FAT DIET; BEHAVIORAL DESPAIR; METABOLIC SYNDROME; RECEPTOR-BINDING;
   DEPRESSION; BRAIN; INSULIN; MELLITUS; GLUCOSE; SYSTEM
AB Diabetes mellitus is accompanied by hormonal and neurochemical changes that can be associated with anxiety and depression. I investigated the antidepressant effect of simvastatin (SMV) on diabetic rats. Rats were divided into control (CTR) and streptozotocin-induced diabetic (STZ) groups and were orally administered 0, 5, or 10 mg/kg of SMV daily for 14 days, then exposed to the forced swimming test (FST). Our results showed that diabetic rats had higher immobility duration than the CTR rats, and SMV decreased this depressive-like behavior in the diabetic rats. However, clomipramine lowered the immobility time in the CTR and STZ rats. STZ decreased serotonin concentration in the hippocampus, which was reversed by SMV and clomipramine. The dopamine concentration in the hippocampus decreased in the STZ groups compared with the CTR groups. However, SMV and clomipramine had no significant effect on the dopamine levels in either the CTR or STZ groups. Corticosterone levels were increased in the untreated STZ group; SMV and clomipramine significantly decreased corticosterone levels in the STZ groups, but had no effect on the CTR groups. In conclusion, SMV exerts an antidepressant-like effect on diabetic rats that are submitted to the FST. The antidepressant-like effect of SMV in the FST appears to be mediated, at least in part, by the biochemical changes to the blood levels of corticosterone and of serotonin concentration in the hippocampus.
C1 Menoufia Univ, Dept Clin Pharmacol, Fac Med, Shibin Al Kawm 32511, Egypt.
C3 Egyptian Knowledge Bank (EKB); Menofia University
RP ElBatsh, MM (corresponding author), Menoufia Univ, Dept Clin Pharmacol, Fac Med, Shibin Al Kawm 32511, Egypt.
EM maha.ali@med.menofia.edu.eg
RI ElBatsh, Maha/AAA-3339-2022
OI ElBatsh, Maha/0000-0002-0052-4299
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NR 67
TC 26
Z9 27
U1 0
U2 13
PU CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS
PI OTTAWA
PA 65 AURIGA DR, SUITE 203, OTTAWA, ON K2E 7W6, CANADA
SN 0008-4212
EI 1205-7541
J9 CAN J PHYSIOL PHARM
JI Can. J. Physiol. Pharmacol.
PD AUG
PY 2015
VL 93
IS 8
BP 649
EP 656
DI 10.1139/cjpp-2014-0560
PG 8
WC Pharmacology & Pharmacy; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Physiology
GA CO4XI
UT WOS:000359163800007
PM 26120891
DA 2025-06-11
ER

PT J
AU Wattanathorn, J
   Ohnon, W
   Thukhammee, W
   Muchmapura, S
   Wannanon, P
   Tong-un, T
AF Wattanathorn, Jintanaporn
   Ohnon, Warin
   Thukhammee, Wipawee
   Muchmapura, Supaporn
   Wannanon, Panakaporn
   Tong-un, Terdthai
TI Cerebroprotective Effect against Cerebral Ischemia of the Combined
   Extract of Oryza sativa and Anethum graveolens in
   Metabolic Syndrome Rats
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Article
ID NECROSIS-FACTOR-ALPHA; NITRIC-OXIDE; OXIDATIVE STRESS; ARTERY OCCLUSION;
   STROKE; ATHEROSCLEROSIS; ASTROCYTES; EXPRESSION; MORTALITY; DISEASE
AB The novel strategy against ischemic stroke in metabolic syndrome (MetS) targeting at oxidative stress and inflammation has gained attention due to the limitation of the current therapy. Due to the antioxidant and anti-inflammation of the combined extract of Oryza sativa and Anethum graveolens, the cerebroprotective effect against cerebral ischemia in MetS condition has been focused. Since no data were available, this study was set up to determine the effects of the combined extract of Oryza sativa L. and Anethum graveolens Linn. against ischemic stroke in the animal model of metabolic syndrome. The possible underlying mechanism was also further investigated. Male Wistar rats (180-220 g) were fed with high-carbohydrate high-fat diet (HCHF diet) to induce metabolic syndrome-like condition. Then, MetS rats were subjected to reperfusion injury at the right middle cerebral artery. The combined extract of O. sativa and A. graveolens (OA extract) at doses of 0.5, 5, and 50 mg/kg BW was fed once daily for 21 days. Neurological assessment was performed every 7 days throughout the experimental period. At the end of study, brain infarction volume, neuron and glial fibrillary acidic protein- (GFAP-) positive cell density, the oxidative stress status, the expressions of proinflammatory cytokines (NF-kappa B, IL-6), and eNOS in the cortical area together with the expression of VCAM-1 and the histological changes of common carotid artery were determined. It was found that OA extract decreased brain infarction, neurological score, oxidative stress status, and inflammatory mediators but increased eNOS expression in the cortical area; the increased VCAM-1 and intima-media thickness together with the reduction of lumen diameter of common carotid artery of MetS eats with MCAO were also mitigated by OA extract. These data suggest the cerebroprotective effect of OA, and the underlying mechanism may occur partly via the improvement of oxidative stress status, inflammation, and brain blood supply.
C1 [Wattanathorn, Jintanaporn; Ohnon, Warin; Thukhammee, Wipawee; Muchmapura, Supaporn; Wannanon, Panakaporn; Tong-un, Terdthai] Khon Kaen Univ, Fac Med, Dept Physiol, Khon Kaen 40002, Thailand.
   [Wattanathorn, Jintanaporn; Thukhammee, Wipawee; Muchmapura, Supaporn; Wannanon, Panakaporn; Tong-un, Terdthai] Khon Kaen Univ, Integrat Complementary Alternat Med Res & Dev Ctr, Khon Kaen 40002, Thailand.
   [Wattanathorn, Jintanaporn; Thukhammee, Wipawee; Muchmapura, Supaporn; Wannanon, Panakaporn; Tong-un, Terdthai] Khon Kaen Univ, Res Inst Human High Performance & Hlth Promot, Khon Kaen 40002, Thailand.
   [Ohnon, Warin] Khon Kaen Univ, Fac Med, Grad Sch, Neurosci Program, Khon Kaen 40002, Thailand.
C3 Khon Kaen University; Khon Kaen University; Khon Kaen University; Khon
   Kaen University
RP Wattanathorn, J (corresponding author), Khon Kaen Univ, Fac Med, Dept Physiol, Khon Kaen 40002, Thailand.; Wattanathorn, J (corresponding author), Khon Kaen Univ, Integrat Complementary Alternat Med Res & Dev Ctr, Khon Kaen 40002, Thailand.; Wattanathorn, J (corresponding author), Khon Kaen Univ, Res Inst Human High Performance & Hlth Promot, Khon Kaen 40002, Thailand.
EM jinwat05@gmail.com
OI Thukhammee, Wipawee/0000-0001-6923-396X; Tong-un,
   Terdthai/0000-0002-5286-0788; Wattanathorn,
   Jintanaporn/0000-0002-7383-2348; Ohn-on, Warin/0000-0001-6552-5850;
   Muchimapura, Supaporn/0000-0001-7756-1955
FU Integrative Complementary Alternative Medicine Research and Development
   Center in Research Institute for Human High Performance and Health
   Promotion, Khon Kaen University, Khon Kaen, Thailand
FX This study was supported by the Integrative Complementary Alternative
   Medicine Research and Development Center in Research Institute for Human
   High Performance and Health Promotion, Khon Kaen University, Khon Kaen,
   Thailand.
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NR 54
TC 16
Z9 16
U1 0
U2 11
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PD NOV 11
PY 2019
VL 2019
AR 9658267
DI 10.1155/2019/9658267
PG 19
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA JQ8AO
UT WOS:000499161600013
PM 31827714
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Ghelani, H
   Razmovski-Naumovski, V
   Nammi, S
AF Ghelani, Hardik
   Razmovski-Naumovski, Valentina
   Nammi, Srinivas
TI Chronic treatment of (R)-α-lipoic acid reduces blood glucose and lipid
   levels in high-fat diet and low-dose streptozotocin-induced metabolic
   syndrome and type 2 diabetes in Sprague-Dawley rats
SO PHARMACOLOGY RESEARCH & PERSPECTIVES
LA English
DT Article
DE (R)-alpha-lipoic acid; high-fat diet; hyperglycemia; hyperlipidemia;
   metabolic syndrome; streptozotocin; type 2 diabetes
ID ALPHA-LIPOIC ACID; ACTIVATED PROTEIN-KINASE; INSULIN-RESISTANCE;
   OXIDATIVE STRESS; ANTIOXIDANT STATUS; ANIMAL-MODELS; CHOLESTEROL;
   PREVENTS; OBESITY; DYSLIPIDEMIA
AB (R)-alpha-lipoic acid (ALA), an essential cofactor in mitochondrial respiration and a potential antioxidant, possesses a wide array of metabolic benefits including antiobesity, glucose lowering, insulin-sensitizing, and lipid-lowering effects. In this study, the curative effects of ALA (100 mg/kg) on a spectrum of conditions related to metabolic syndrome and type 2 diabetes (T2D) were investigated in a high-fat diet (HFD)-fed and low-dose streptozotocin (STZ)-induced rat model of metabolic syndrome and T2D. The marked rise in the levels of glucose, triglycerides, total-cholesterol, LDL-cholesterol, and VLDL-cholesterol in the blood of HFD-fed and low-dose STZ-injected rats were significantly reduced by ALA treatment. Furthermore, ALA treatment significantly increased the serum HDL-cholesterol levels and tended to inhibit diabetes-induced weight reduction. Mathematical computational analysis revealed that ALA also significantly improved insulin sensitivity and reduced the risk of atherosclerotic lesions and coronary atherogenesis. This study provides scientific evidence to substantiate the use of ALA to mitigate the glucose and lipid abnormality in metabolic syndrome and T2D.
C1 [Ghelani, Hardik; Razmovski-Naumovski, Valentina; Nammi, Srinivas] Western Sydney Univ, Sch Sci & Hlth, Sydney, NSW 2751, Australia.
   [Ghelani, Hardik; Razmovski-Naumovski, Valentina; Nammi, Srinivas] Western Sydney Univ, Natl Inst Complementary Med, Sydney, NSW 2751, Australia.
   [Razmovski-Naumovski, Valentina] Univ New South Wales, South Western Sydney Clin Sch, Sch Med, Sydney, NSW 2052, Australia.
C3 Western Sydney University; Western Sydney University; University of New
   South Wales Sydney
RP Nammi, S (corresponding author), Western Sydney Univ, Sch Sci & Hlth, Sydney, NSW 2751, Australia.; Nammi, S (corresponding author), Western Sydney Univ, Natl Inst Complementary Med, Sydney, NSW 2751, Australia.
EM s.nammi@westernsydney.edu.au
RI Nammi, Srinivas/I-2983-2013
OI Nammi, Srinivas/0000-0002-4735-2789; Ghelani, Dr
   Hardik/0000-0001-5960-7702
FU Western Sydney University, Australia
FX This research study was supported under the Higher Degree Research
   Training Scheme funds provided to HG by the Western Sydney University,
   Australia.
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NR 83
TC 32
Z9 34
U1 2
U2 11
PU JOHN WILEY & SONS LTD
PI CHICHESTER
PA THE ATRIUM, SOUTHERN GATE, CHICHESTER PO19 8SQ, W SUSSEX, ENGLAND
SN 2052-1707
J9 PHARMACOL RES PERSPE
JI Pharmacol. Res. Perspect.
PD JUN
PY 2017
VL 5
IS 3
AR e00306
DI 10.1002/prp2.306
PG 12
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA FD3QF
UT WOS:000407446800002
PM 28603627
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Del Ben, M
   Baratta, F
   Polimeni, L
   Angelico, F
AF Del Ben, Maria
   Baratta, Francesco
   Polimeni, Licia
   Angelico, Francesco
TI Non-alcoholic fatty liver disease and cardiovascular disease:
   epidemiological, clinical and pathophysiological evidences
SO INTERNAL AND EMERGENCY MEDICINE
LA English
DT Article
DE Non-alcoholic fatty liver disease; Non-alcoholic steatohepatitis;
   Cardiovascular disease; Metabolic syndrome
ID INTIMA-MEDIA THICKNESS; METABOLIC SYNDROME; CAROTID ATHEROSCLEROSIS;
   LIPID-PEROXIDATION; INSULIN-RESISTANCE; HEPATIC STEATOSIS; CORONARY
   PLAQUES; RISK-FACTORS; FOLLOW-UP; ARTERY
AB Non-alcoholic fatty liver disease is recognized as the most common and emerging chronic liver disease in western countries. The disease has been traditionally interpreted as a possibly progressing condition to liver fibrosis and cirrhosis. However, recently, a large number of publications have demonstrated that people with non-alcoholic fatty liver have an increased chance of developing cardiovascular diseases, which represent the major causes of death in this setting. This association is mainly explained by the atherogenic profile of the metabolic syndrome a condition frequently associated with fatty liver, which may represent its hepatic component. Some studies have also shown an association independent of traditional risk factors or of the clinical features of the metabolic syndrome. In this setting, cardiovascular disease seems to be the consequence of low-grade chronic inflammation and increased oxidative stress. Most studies did not differentiate cardiovascular risk between simple steatosis and non-alcoholic steatohepatitis, although the latter seems to be at higher cardiovascular risk. Few studies have investigated the direct correlation between hepatic inflammation and atherosclerosis. Genetic studies will probably improve the interpretation of the increased cardiovascular risk in patients with fatty liver and no metabolic syndrome.
C1 [Del Ben, Maria; Baratta, Francesco; Polimeni, Licia; Angelico, Francesco] Univ Roma La Sapienza, Dipartimento Med Interna & Specialita Med, Clin Med 1, Policlin Umberto 1, Viale Policlin 155, I-00161 Rome, Italy.
C3 Sapienza University Rome; University Hospital Sapienza Rome
RP Angelico, F (corresponding author), Univ Roma La Sapienza, Dipartimento Med Interna & Specialita Med, Clin Med 1, Policlin Umberto 1, Viale Policlin 155, I-00161 Rome, Italy.
EM francesco.angelico@uniroma1.it
RI Del Ben, Maria/AAE-7603-2020; Angelico, Francesco/AAB-6585-2020
OI Baratta, Francesco/0000-0003-1708-272X
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NR 59
TC 29
Z9 29
U1 0
U2 6
PU SPRINGER-VERLAG ITALIA SRL
PI MILAN
PA VIA DECEMBRIO, 28, MILAN, 20137, ITALY
SN 1828-0447
EI 1970-9366
J9 INTERN EMERG MED
JI Intern. Emerg. Med.
PD OCT
PY 2012
VL 7
SU 3
BP S291
EP S296
DI 10.1007/s11739-012-0819-4
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA V45UX
UT WOS:000209842600018
PM 23073870
DA 2025-06-11
ER

PT J
AU Perez-Chada, LM
   Merola, JF
AF Perez-Chada, Lourdes M.
   Merola, Joseph F.
TI Comorbidities associated with psoriatic arthritis: Review and update
SO CLINICAL IMMUNOLOGY
LA English
DT Review
DE Psoriatic arthritis; Comorbidity; Screening; Management
ID CARDIOVASCULAR-DISEASE RISK; INFLAMMATORY-BOWEL-DISEASE; FATTY
   LIVER-DISEASE; QUALITY-OF-LIFE; RHEUMATOID-ARTHRITIS; METABOLIC
   SYNDROME; ANKYLOSING-SPONDYLITIS; PROSPECTIVE MULTICENTER; MALIGNANCY
   INCIDENCE; INSULIN-RESISTANCE
AB Psoriatic arthritis is an inflammatory arthropathy frequently associated with psoriasis and several other comorbidities. The goal of this review is to summarize the available evidence on the epidemiology, clinical implications, pathological mechanisms proposed, and screening and management recommendations for the comorbidities related with PsA. Reported comorbidities include cardiovascular disease, metabolic syndrome, obesity, diabetes mellitus, dyslipidemia, inflammatory bowel disease, fatty liver disease, uveitis, kidney disease, infections, osteoporosis, depression, central sensitization syndrome, and gout. Given that these comorbidities may affect both clinical outcomes and the management for these patients, their recognition and monitoring by all health-care providers caring for patients with psoriatic arthritis is of utmost importance.
C1 [Perez-Chada, Lourdes M.; Merola, Joseph F.] Harvard Med Sch, Brigham & Womens Hosp, Dept Dermatol, Boston, MA 02115 USA.
   [Merola, Joseph F.] Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Div Rheumatol, Boston, MA 02115 USA.
C3 Harvard University; Harvard Medical School; Harvard University Medical
   Affiliates; Brigham & Women's Hospital; Harvard University; Harvard
   University Medical Affiliates; Brigham & Women's Hospital; Harvard
   Medical School
RP Merola, JF (corresponding author), Brigham & Womens Hosp, Dept Dermatol, 221 Longwood Ave, Boston, MA 02115 USA.
EM jfmerola@bwh.harvard.edu
OI Merola, Joseph/0000-0001-6514-4353
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NR 126
TC 91
Z9 94
U1 1
U2 14
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 1521-6616
EI 1521-7035
J9 CLIN IMMUNOL
JI Clin. Immunol.
PD MAY
PY 2020
VL 214
AR 108397
DI 10.1016/j.clim.2020.108397
PG 9
WC Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology
GA LK2MA
UT WOS:000530692800006
PM 32229290
DA 2025-06-11
ER

PT J
AU Calvo, MS
   Mehrotra, A
   Beelman, RB
   Nadkarni, G
   Wang, L
   Cai, W
   Goh, BC
   Kalaras, MD
   Uribarri, J
AF Calvo, Mona S.
   Mehrotra, Anita
   Beelman, Robert B.
   Nadkarni, Girish
   Wang, Lingzhi
   Cai, Weijing
   Goh, Boon Cher
   Kalaras, Michael D.
   Uribarri, Jaime
TI A Retrospective Study in Adults with Metabolic Syndrome: Diabetic Risk
   Factor Response to Daily Consumption of Agaricus bisporus (White
   Button Mushrooms)
SO PLANT FOODS FOR HUMAN NUTRITION
LA English
DT Article
DE White button mushrooms; Metabolic syndrome; Type 2 diabetes;
   Antioxidants; Ergothioneine; Advanced glycation end products;
   Adiponectin; Oxidative stress
ID IMPROVES INSULIN-RESISTANCE; OXIDATIVE STRESS; EDIBLE MUSHROOMS; VITAMIN
   D-2; ERGOTHIONEINE; INFLAMMATION; RATS; BIOAVAILABILITY; QUANTIFICATION;
   INDIVIDUALS
AB Adults with metabolic syndrome from different race/ethnicities are often predisposed to developing type 2 diabetes (T2D); however, growing evidence suggests that healthy diets and lifestyle choices can significantly slow or prevent progression to T2D. This poorly understood relationship to healthy dietary patterns and prevention of T2D motivated us to conduct a retrospective analysis to determine the potential impact of a minor dietary lifestyle change (daily mushroom consumption) on known T2D risk factors in racially diverse adults with confirmed features of the metabolic syndrome. Retrospectively, we studied 37 subjects who had participated in a dietary intervention focused on vitamin D bioavailability from white button mushrooms (WBM). All 37 had previously completed a 16-week study where they consumed 100 g of WBM daily and were then followed-up for one month during which nomushrooms were consumed. We analyzed differences in serum risk factors from baseline to 16-week, and from baseline to one-month follow-up. Measurement of serum diabetic risk factors included inflammatory and oxidative stress markers and the antioxidant component naturally rich in mushrooms, ergothioneine. Significant beneficial health effects were observed at 16-week with the doubling of ergothioneine from baseline, increases in the antioxidant marker ORAC (oxygen radical absorption capacity) and anti-inflammatory hormone, adiponectin and significant decreases in serum oxidative stress inducing factors, carboxymethyllysine (CML) and methylglyoxal (MG), but no change in the lipid oxidative stress marker 8-isoprostane, leptin or measures of insulin resistance or glucose metabolism. We conclude that WBM contain a variety of compounds with potential anti-inflammatory and antioxidant health benefits that can occur with frequent consumption over time in adults predisposed to T2D. Well-controlled studies are needed to confirm these findings and identify the specific mushroom components beneficial to health.
C1 [Calvo, Mona S.] US FDA, Ctr Food Safety & Appl Nutr, MOD-1,HFS-025,8301 Muirkirk Rd, Laurel, MD 20708 USA.
   [Mehrotra, Anita; Nadkarni, Girish; Uribarri, Jaime] Icahn Sch Med Mt Sinai, Dept Med, 1 Gustave L Levy Pl,Box 1147, New York, NY 10029 USA.
   [Beelman, Robert B.; Kalaras, Michael D.] Penn State Univ, Dept Food Sci, 202 Rodney A Erickson Food Sci Bldg, University Pk, PA 16802 USA.
   [Wang, Lingzhi; Goh, Boon Cher] Natl Univ Singapore, Canc Sci Inst, 14 Med Dr, Singapore 117599, Singapore.
   [Cai, Weijing] Icahn Sch Med Mt Sinai, Dept Geriatr, 1 Gustave L Levy Pl, New York, NY 10029 USA.
C3 US Food & Drug Administration (FDA); Icahn School of Medicine at Mount
   Sinai; Pennsylvania Commonwealth System of Higher Education (PCSHE);
   Pennsylvania State University; Pennsylvania State University -
   University Park; Penn State Behrend; National University of Singapore;
   Icahn School of Medicine at Mount Sinai
RP Uribarri, J (corresponding author), Icahn Sch Med Mt Sinai, Dept Med, 1 Gustave L Levy Pl,Box 1147, New York, NY 10029 USA.
EM Jaime.uribarri@mssm.edu
RI Uribarri, Jaime/ADX-7655-2022; mirzaei, hamed/X-2374-2018; Calvo,
   Mona/J-8445-2019
OI uribarri, jaime/0000-0001-9826-1134
FU Mushroom Council; Australian Mushroom Growers Council
FX This study was made possible by funding from the Mushroom Council and
   the Australian Mushroom Growers Council, neither of which participated
   in the study design, data collection, data analysis or interpretation of
   results, or manuscript preparation.
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NR 30
TC 50
Z9 57
U1 2
U2 41
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0921-9668
EI 1573-9104
J9 PLANT FOOD HUM NUTR
JI Plant Food Hum. Nutr.
PD SEP
PY 2016
VL 71
IS 3
BP 245
EP 251
DI 10.1007/s11130-016-0552-7
PG 7
WC Plant Sciences; Chemistry, Applied; Food Science & Technology; Nutrition
   & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Chemistry; Food Science & Technology; Nutrition &
   Dietetics
GA EA8MA
UT WOS:000386887700004
PM 27193019
DA 2025-06-11
ER

PT J
AU Benham, JL
   Goldberg, A
   Teede, H
   Tay, CT
AF Benham, J. L.
   Goldberg, A.
   Teede, H.
   Tay, C. T.
TI Polycystic ovary syndrome: associations with cardiovascular disease
SO CLIMACTERIC
LA English
DT Review
DE Polycystic ovary syndrome; women's health; cardiovascular disease
ID MIDDLE-AGED WOMEN; SCIENTIFIC STATEMENT; DIAGNOSTIC-CRITERIA; PREGNANCY
   OUTCOMES; METABOLIC SYNDROME; SYNDROME PCOS; RISK-FACTORS; CORONARY;
   POPULATION; CALCIFICATION
AB Polycystic ovary syndrome (PCOS), characterized by abnormal menstrual periods, elevated androgen levels and polycystic ovary morphology on ultrasound, is the most common endocrine disorder among females. PCOS is associated with cardiovascular disease (CVD) risk factors including diabetes, obesity, metabolic syndrome, adverse pregnancy outcomes such as pre-eclampsia and psychosocial distress including depression. Previous evidence on the association between PCOS and CVD is inconclusive but the latest 2023 International Evidence-Based PCOS Guideline identifies PCOS as a risk factor for CVD. This review will discuss the relationship between PCOS and CVD along with current direction for CVD screening and prevention among individuals with PCOS.
C1 [Benham, J. L.] Univ Calgary, Cumming Sch Med, Dept Med, Calgary, AB, Canada.
   [Benham, J. L.] Univ Calgary, Cumming Sch Med, Dept Community Hlth Sci, Calgary, AB, Canada.
   [Goldberg, A.] Univ Toronto, Dept Med, Toronto, ON, Canada.
   [Teede, H.; Tay, C. T.] Monash Univ, Monash Ctr Hlth Res & Implementat, Fac Med Nursing & Hlth Sci, Melbourne, Vic, Australia.
   [Benham, J. L.] Univ Calgary, 3280 Hosp Dr NW, Calgary, AB T2N 4Z6, Canada.
C3 University of Calgary; University of Calgary; University of Toronto;
   Monash University; University of Calgary
RP Benham, JL (corresponding author), Univ Calgary, 3280 Hosp Dr NW, Calgary, AB T2N 4Z6, Canada.
RI Benham, Jamie/KFS-9089-2024; Tay, Jillian/AAE-6749-2020
FU Australian government through the National Health and Medical Research
   Council (NHMRC) Centre for Research Excellence in Women's Health in
   Reproductive Life (CRE WHiRL) [1171592]; NHMRC fellowship [1171592]; 
   [2009326]
FX International PCOS Guideline development is funded by the Australian
   government through the National Health and Medical Research Council
   (NHMRC) Centre for Research Excellence in Women's Health in Reproductive
   Life (CRE WHiRL) [#1171592]. C.T.T. is also supported by grant
   [#1171592]. H.T. is funded by an NHMRC fellowship [#2009326].
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NR 61
TC 9
Z9 9
U1 3
U2 13
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1369-7137
EI 1473-0804
J9 CLIMACTERIC
JI Climacteric
PD JAN 2
PY 2024
VL 27
IS 1
SI SI
BP 47
EP 52
DI 10.1080/13697137.2023.2282689
EA DEC 2023
PG 6
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA FC1F2
UT WOS:001122672600001
PM 38073517
OA Bronze
DA 2025-06-11
ER

PT J
AU Kim, UJ
   Choi, EJ
   Park, H
   Lee, HA
   Park, B
   Kim, H
   Hong, Y
   Jung, S
   Park, H
AF Kim, Ui-Jeong
   Choi, Eun-Jeong
   Park, Hyunjin
   Lee, Hye-Ah
   Park, Bomi
   Kim, Haesoon
   Hong, Youngsun
   Jung, Seungyoun
   Park, Hyesook
TI The Mediating Effect of Inflammation between the Dietary and
   Health-Related Behaviors and Metabolic Syndrome in Adolescence
SO NUTRIENTS
LA English
DT Article
DE latent class analysis; mediation analysis; metabolic syndrome;
   health-related behavior; cohort
ID CORONARY-HEART-DISEASE; PHYSICAL-ACTIVITY; CHILDREN; STRESS; RISK; LIFE
AB Chronic diseases develop via complex pathways, depending on the degree of exposure to risk factors from early in life and childhood onward. Metabolic syndrome has multiple risk factors, including genetic factors, inappropriate diet, and insufficient physical activity. This study classified health-related behavior classes in childhood and adolescents and analyzed the direct and indirect effects of each class on the metabolic risk in inflammation-mediated pathways. We identified the health-related lifestyle classes based on health-related behavior indicators in subjects aged 3-15 years who participated in the Ewha Birth and Growth Cohort Study by using a latent class analysis. A mediation analysis was performed to access the direct and indirect effects of each class on the continuous metabolic syndrome score (cMetS), with the inflammatory index used as a mediating factor. Subjects were classified into inactive and positive lifestyle classes according to their characteristics. In the inactive lifestyle class, interleukin (IL)-6 and cMetS had a significant association. The study confirmed that IL-6 exerts a significant indirect effect between inactive lifestyle and cMetS. This result supports previous studies. Since the health behaviors of children and adolescents can affect the likelihood of subsequent metabolic syndrome, appropriate health behavior interventions for this period are needed.
C1 [Kim, Ui-Jeong; Park, Hyunjin; Park, Hyesook] Ewha Womans Univ, Dept Prevent Med, Grad Program Syst Hlth Sci & Engn, Seoul 07804, South Korea.
   [Choi, Eun-Jeong] Ewha Womans Univ, Coll Med, Dept Prevent Med, Seoul 07804, South Korea.
   [Lee, Hye-Ah] Ewha Womans Univ, Mokdong Hosp, Clin Trial Ctr, Seoul 07985, South Korea.
   [Park, Bomi] Chung Ang Univ, Coll Med, Dept Prevent Med, Seoul 06974, South Korea.
   [Kim, Haesoon] Ewha Womans Univ, Coll Med, Dept Pediat, Seoul 07804, South Korea.
   [Hong, Youngsun] Ewha Womans Univ, Coll Med, Dept Internal Med, Seoul 07804, South Korea.
   [Jung, Seungyoun] Ewha Womans Univ, Dept Nutr Sci & Food Management, Grad Program Syst Hlth Sci & Engn, Seoul 03760, South Korea.
C3 Ewha Womans University; Ewha Womans University; Ewha Womans University;
   Chung Ang University; Chung Ang University Hospital; Ewha Womans
   University; Ewha Womans University; Ewha Womans University
RP Park, H (corresponding author), Ewha Womans Univ, Dept Prevent Med, Grad Program Syst Hlth Sci & Engn, Seoul 07804, South Korea.
EM its0912@naver.com; choiej_89@naver.com; hyunjin9191@ewhain.net;
   khyeah@ewha.ac.kr; bomi.s.park@gmail.com; hyesk@ewha.ac.kr;
   imhys@ewha.ac.kr; sjung131@ewha.ac.kr; hpark@ewha.ac.kr
RI Park, Hyun Jin/HSG-6465-2023; Lee, Hye Ah/ABC-8131-2021
OI Park, Hyesook/0000-0002-9359-6522; Park, Hyunjin/0000-0001-6536-8787;
   Kim, Ui-Jeong/0000-0001-8362-2232
FU Basic Science Research Program through the National Research Foundation
   of Korea (NRF) - Ministry of Science and ICT [NRF-2020R1F1A1062227]
FX This research was supported by the Basic Science Research Program
   through the National Research Foundation of Korea (NRF), funded by the
   Ministry of Science and ICT (NRF-2020R1F1A1062227).
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NR 39
TC 3
Z9 3
U1 2
U2 22
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JUN
PY 2022
VL 14
IS 11
AR 2339
DI 10.3390/nu14112339
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 2B0UZ
UT WOS:000809911700001
PM 35684139
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Asghar, M
   Monjok, E
   Kouamou, G
   Ohia, SE
   Bagchi, D
   Lokhandwala, MF
AF Asghar, Mohammad
   Monjok, Emmanuel
   Kouamou, Ghislaine
   Ohia, Sunny E.
   Bagchi, Debasis
   Lokhandwala, Mustafa F.
TI Super CitriMax (HCA-SX) attenuates increases in oxidative stress,
   inflammation, insulin resistance, and body weight in developing obese
   Zucker rats
SO MOLECULAR AND CELLULAR BIOCHEMISTRY
LA English
DT Article
DE metabolic syndrome; syndrome X; hypertension; HOMA; blood pressure;
   Garcinia cambogia
ID NECROSIS-FACTOR-ALPHA; (-)-HYDROXYCITRIC ACID; TNF-ALPHA;
   SKELETAL-MUSCLE; ADIPOSE-TISSUE; RECEPTOR; RESTRICTION; EXPRESSION;
   EXERCISE; IMPROVES
AB Super CitriMax (HCA-SX) is a novel calcium/potassium salt of (-)-hydroxycitric acid extracted from the dried fruit rind of the plant Garcinia cambogia, and commonly consumed as weight loss dietary supplement. In the present study, we investigated the effect of HCA-SX on inflammation, oxidative stress and insulin resistance in developing obese Zucker rats, an animal model of type II diabetes associated with inflammation and oxidative stress. Male Zucker rats (5-week old) were supplemented with vehicle (control) and HCA-SX in drinking water for 7 weeks. Oxidative stress markers, including malondialdehyde (MDA), protein carbonyl (DNPH), and protein tyrosine nitration (tyr-NO2) were measured in the liver and kidney tissues using biochemical and immunoblotting techniques. Compared to controls, the levels of MDA, DNPH and tyr-NO2 were lower in the liver and kidney of HCA-SX-treated animals. Furthermore, the levels of C-reactive protein and interleukin-6, markers of inflammation measured by ELISA, were lower in the plasma of HCA-SX-supplemented animals compared to controls, as were levels of fasting plasma insulin, glucose, and triglycerides. Interestingly, insulin resistance did not develop in HCA-SX-supplemented rats. Food-intake and body weight gain was also lower in rats supplemented with HCA-SX compared to their control counterparts. These results suggest that HCA-SX supplementation in obese Zucker rats reduces food-intake, body weight gain, and also attenuates the increases in inflammation, oxidative stress, and insulin resistance observed in untreated animals. Therefore, HCA-SX may be used as an intervention to overcome obesity-related complications, including inflammation, oxidative stress, and insulin resistance.
C1 Univ Houston, Coll Pharm, Dept Pharmacol & Pharmaceut Sci, Houston, TX 77030 USA.
   Creighton Univ, Med Ctr, Dept Pharm Sci, Omaha, NE 68178 USA.
   InterHlth Nutraceut Inc, Benicia, CA USA.
C3 University of Houston System; University of Houston; Creighton
   University
RP Asghar, M (corresponding author), Univ Houston, Coll Pharm, Dept Pharmacol & Pharmaceut Sci, Houston, TX 77030 USA.
EM masghar@mail.uh.edu
RI Monjok, Emmanuel/AAJ-6382-2020
OI Monjok, Emmanuel/0000-0001-6750-771X
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NR 36
TC 61
Z9 65
U1 0
U2 15
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0300-8177
EI 1573-4919
J9 MOL CELL BIOCHEM
JI Mol. Cell. Biochem.
PD OCT
PY 2007
VL 304
IS 1-2
BP 93
EP 99
DI 10.1007/s11010-007-9489-3
PG 7
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA 212WZ
UT WOS:000249629000010
PM 17503004
DA 2025-06-11
ER

PT J
AU Azhdari, M
   Karandish, M
   Mansoori, A
AF Azhdari, Maryam
   Karandish, Majid
   Mansoori, Anahita
TI Metabolic benefits of curcumin supplementation in patients with
   metabolic syndrome: A systematic review and meta-analysis of randomized
   controlled trials
SO PHYTOTHERAPY RESEARCH
LA English
DT Review
DE curcumin; metabolic syndrome; turmeric
ID TYPE-2 DIABETES-MELLITUS; DOUBLE-BLIND; OXIDATIVE STRESS; BLOOD-GLUCOSE;
   PIPERINE COMBINATION; LIPID-ACCUMULATION; 3T3-L1 ADIPOCYTES;
   ENZYME-ACTIVITIES; IN-VITRO; ANTIOXIDANT
AB The finding of studies on the effect of curcumin extract on metabolic factor in patients with metabolic syndrome has had arguable results. This systematic review with meta-analysis of randomized controlled trials (RCT) aimed to analyze the effect of curcumin/turmeric on metabolic factors in patients with metabolic syndrome. The PICO strategy was used to establish the guiding question of this review. Several databases for RCT were searched until September 2018. Of the 144 articles initially identified, seven trials met the eligibility criteria. A random-effects model with a mean weight difference (WMD) and a 95% confidence interval was performed for quantitative data synthesis. Pooled estimates of WMD were calculated between intervention and control groups using random-effects model in the presence of high level of heterogeneity between the studies. The results showed significant improvement of fasting blood glucose (p = 0.01), triglycerides (p < 0.001), high-density lipoprotein cholesterol (p = 0.003), and diastolic blood pressure (p = 0.007) levels. Curcumin was not associated with a significant change in waist circumference measurement (p = 0.6) and systolic blood pressure level (p = 0.269). Curcumin supplementation improves some components of metabolic syndrome.
C1 [Azhdari, Maryam; Mansoori, Anahita] Ahvaz Jundishapur Univ Med Sci, Nutr & Metab Dis Res Ctr, Ahvaz, Iran.
   [Azhdari, Maryam] Shahid Sadoughi Univ Med Sci & Hlth Serv, Fac Med, Dept Clin Biochem, Yazd, Iran.
   [Karandish, Majid] Ahvaz Jundishapur Univ Med Sci, Diabet Res Ctr, Hlth Res Inst, Ahvaz, Iran.
C3 Ahvaz Jundishapur University of Medical Sciences (AJUMS); Shahid
   Sadoughi University of Medical Sciences; Ahvaz Jundishapur University of
   Medical Sciences (AJUMS)
RP Mansoori, A (corresponding author), Ahvaz Jundishapur Univ Med Sci, Fac Paramed, Nutr Dept, POB 61357-15794, Ahvaz, Iran.
EM mansoori_anahita@yahoo.com
RI azhdari, maryam/ABG-8345-2020; Karandish, Majid/I-3073-2018; Mansoori,
   Anahita/G-3737-2016
OI Azhdari, Maryam/0000-0003-2110-9817; Mansoori,
   Anahita/0000-0003-2935-9589
FU Ahvaz Jundishapur University of Medical Sciences [NRC-9721]
FX Ahvaz Jundishapur University of Medical Sciences, Grant/Award Number:
   NRC-9721
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NR 78
TC 65
Z9 68
U1 2
U2 11
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0951-418X
EI 1099-1573
J9 PHYTOTHER RES
JI Phytother. Res.
PD MAY
PY 2019
VL 33
IS 5
BP 1289
EP 1301
DI 10.1002/ptr.6323
PG 13
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA IA2PF
UT WOS:000469402900004
PM 30941814
DA 2025-06-11
ER

PT J
AU Labouesse, MA
   Lassalle, O
   Richetto, J
   Iafrati, J
   Weber-Stadlbauer, U
   Notter, T
   Gschwind, T
   Pujadas, L
   Soriano, E
   Reichelt, AC
   Labouesse, C
   Langhans, W
   Chavis, P
   Meyer, U
AF Labouesse, M. A.
   Lassalle, O.
   Richetto, J.
   Iafrati, J.
   Weber-Stadlbauer, U.
   Notter, T.
   Gschwind, T.
   Pujadas, L.
   Soriano, E.
   Reichelt, A. C.
   Labouesse, C.
   Langhans, W.
   Chavis, P.
   Meyer, U.
TI Hypervulnerability of the adolescent prefrontal cortex to nutritional
   stress via reelin deficiency
SO MOLECULAR PSYCHIATRY
LA English
DT Article
ID DENDRITIC SPINE DENSITY; LONG-TERM DEPRESSION; SYNAPTIC PLASTICITY;
   BEHAVIORAL FLEXIBILITY; COGNITIVE PERFORMANCE; ALZHEIMERS-DISEASE;
   METABOLIC SYNDROME; OBESE ADOLESCENTS; RECEPTOR-ACTIVITY; WORKING-MEMORY
AB Overconsumption of high-fat diets (HFDs) can critically affect synaptic and cognitive functions within telencephalic structures such as the medial prefrontal cortex (mPFC). The underlying mechanisms, however, remain largely unknown. Here we show that adolescence is a sensitive period for the emergence of prefrontal cognitive deficits in response to HFD. We establish that the synaptic modulator reelin (RELN) is a critical mediator of this vulnerability because (1) periadolescent HFD (pHFD) selectively downregulates prefrontal RELN+ cells and (2) augmenting mPFC RELN levels using transgenesis or prefrontal pharmacology prevents the pHFD-induced prefrontal cognitive deficits. We further identify N-methyl-D-aspartate-dependent long-term depression (NMDA-LTD) at prefrontal excitatory synapses as a synaptic signature of this association because pHFD abolishes NMDA-LTD, a function that is restored by RELN overexpression. We believe this study provides the first mechanistic insight into the vulnerability of the adolescent mPFC towards nutritional stress, such as HFDs. Our findings have primary relevance to obese individuals who are at an increased risk of developing neurological cognitive comorbidities, and may extend to multiple neuropsychiatric and neurological disorders in which RELN deficiency is a common feature.
C1 [Labouesse, M. A.; Weber-Stadlbauer, U.; Langhans, W.; Meyer, U.] Swiss Fed Inst Technol, Physiol & Behav Lab, Schorenstr 16, CH-8603 Schwerzenbach, Switzerland.
   [Labouesse, M. A.; Richetto, J.; Weber-Stadlbauer, U.; Notter, T.; Meyer, U.] Univ Zurich Vetsuisse, Inst Pharmacol & Toxicol, Winterthurerstr 260, CH-8057 Zurich, Switzerland.
   [Lassalle, O.; Iafrati, J.] Aix Marseille Univ, INSERM, INMED UMR S 901, Marseille, France.
   [Gschwind, T.] Univ Zurich, Inst Pharmacol & Toxicol, Zurich, Switzerland.
   [Pujadas, L.; Soriano, E.] Univ Barcelona, Dept Cell Biol Physiol & Immunol, Barcelona, Spain.
   [Pujadas, L.; Soriano, E.] Ctr Invest Red Enfermedades Neurodegenerat CIBERN, Madrid, Spain.
   [Pujadas, L.; Soriano, E.] Vall DHebron Inst Recerca VHIR, Barcelona, Spain.
   [Soriano, E.] Inst Catalana Recerca & Estudis Avancats ICREA Ac, Barcelona, Spain.
   [Reichelt, A. C.] RMIT, Sch Hlth & Biomed Sci, Melbourne, Vic, Australia.
   [Labouesse, C.] Ecole Polytech Fed Lausanne, Lab Cell Biophys, Lausanne, Switzerland.
   [Labouesse, C.] Univ Cambridge, Wellcome Trust, Med Res Council Cambridge Stem Cell Inst, Cambridge, England.
   [Meyer, U.] Univ Zurich, Neurosci Ctr Zurich ZNZ, Zurich, Switzerland.
   [Labouesse, M. A.] Columbia Univ, New York State Psychiat Inst, Kolb 3rd Floor,1051 Riverside Dr, New York, NY 10032 USA.
C3 Swiss Federal Institutes of Technology Domain; ETH Zurich; University of
   Zurich; Institut National de la Sante et de la Recherche Medicale
   (Inserm); Aix-Marseille Universite; University of Zurich; University of
   Barcelona; Autonomous University of Barcelona; Hospital Universitari
   Vall d'Hebron; Vall d'Hebron Institut de Recerca (VHIR); ICREA; Royal
   Melbourne Institute of Technology (RMIT); Swiss Federal Institutes of
   Technology Domain; Ecole Polytechnique Federale de Lausanne; Wellcome
   Trust Sanger Institute; Wellcome Trust; University of Cambridge;
   University of Zurich; New York State Psychiatry Institute; Columbia
   University
RP Labouesse, MA (corresponding author), Swiss Fed Inst Technol, Physiol & Behav Lab, Schorenstr 16, CH-8603 Schwerzenbach, Switzerland.; Meyer, U (corresponding author), Univ Zurich Vetsuisse, Inst Pharmacol & Toxicol, Winterthurerstr 260, CH-8057 Zurich, Switzerland.; Chavis, P (corresponding author), INMED INSERM U901, Parc Sci Luminy 63,Ave Luminy, F-13273 Marseille, France.; Labouesse, MA (corresponding author), Columbia Univ, New York State Psychiat Inst, Kolb 3rd Floor,1051 Riverside Dr, New York, NY 10032 USA.
EM marie.labouesse@gmail.com; pascale.chavis@inserm.fr;
   urs.meyer@vetpharm.uzh.ch
RI Labouesse, Marie/AAC-6907-2019; Richetto, Juliet/AAC-7285-2021;
   Lassalle, Olivier/M-7939-2016; Soriano, Eduardo/AAB-3216-2019; Notter,
   Tina/A-3946-2017; Richetto, Juliet/Q-2865-2016; Chavis,
   Pascale/M-8312-2016; Gschwind, Tilo/D-3324-2017; PUJADAS,
   LLUIS/O-7442-2015; Weber-Stadlbauer, Ulrike/A-6061-2017; Meyer,
   Urs/C-4602-2016
OI Labouesse, Marie/0000-0002-6850-5852; Notter, Tina/0000-0001-9953-5256;
   Richetto, Juliet/0000-0002-8313-3348; Labouesse,
   Celine/0000-0002-9791-898X; Chavis, Pascale/0000-0002-3038-1014;
   Gschwind, Tilo/0000-0003-4261-218X; PUJADAS, LLUIS/0000-0003-3890-8279;
   Weber-Stadlbauer, Ulrike/0000-0002-5278-9993; Meyer,
   Urs/0000-0001-7244-0345; Reichelt, Amy/0000-0002-0637-0411
FU Swiss National Science Foundation [310030_146217]; European Union
   [259679]; INSERM; ETH Zurich; MINECO (Spain) [SAF2013-42445R];
   Australian Research Council [DE140101071]; Swiss National Science
   Foundation (SNF) [310030_146217] Funding Source: Swiss National Science
   Foundation (SNF); Australian Research Council [DE140101071] Funding
   Source: Australian Research Council
FX This work was supported by the Swiss National Science Foundation (Grant
   No. 310030_146217) and the European Union Seventh Framework Program
   (FP7/2007-2011) (Grant No. 259679) (to UM), by INSERM (to PC), by ETH
   Zurich (to WL) and by MINECO (Spain, SAF2013-42445R) (to ES). ACR is the
   recipient of an Australian Research Council Discovery Early Career
   Research Award (DE140101071). We are grateful to F Mouttet, E Weber, F
   Muller, S Giovanoli and S Kaufman for assistance in experimentation or
   genotyping; M Riva and D Ramachandran for helpful discussions; N
   Jejelava and M Arnold for advice on surgery; and the animal technician
   team for contribution to animal husbandry. We thank the National
   Institute of Mental Health's Chemical Synthesis and Drug Supply Program
   for providing CNQX, NBQX and D-APV.
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NR 75
TC 52
Z9 56
U1 3
U2 16
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1359-4184
EI 1476-5578
J9 MOL PSYCHIATR
JI Mol. Psychiatr.
PD JUL
PY 2017
VL 22
IS 7
BP 961
EP 971
DI 10.1038/mp.2016.193
PG 11
WC Biochemistry & Molecular Biology; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Biochemistry & Molecular Biology; Neurosciences & Neurology; Psychiatry
GA EY3YK
UT WOS:000403911900004
PM 27843148
OA Bronze
DA 2025-06-11
ER

PT J
AU Shibata, S
   Fujita, T
AF Shibata, Shigeru
   Fujita, Toshiro
TI Mineralocorticoid receptors in the pathophysiology of chronic kidney
   diseases and the metabolic syndrome
SO MOLECULAR AND CELLULAR ENDOCRINOLOGY
LA English
DT Review
DE Aldosterone; Mineralocorticoid receptor; Metabolic syndrome; Podocytes;
   Rac1; Salt-sensitive hypertension
ID NF-KAPPA-B; INTERCELLULAR-ADHESION MOLECULE-1; BLOOD-PRESSURE;
   ALDOSTERONE BLOCKER; PLASMA-ALDOSTERONE; HYPERTENSIVE-RATS;
   11-BETA-HYDROXYSTEROID DEHYDROGENASE; RESISTANT HYPERTENSION; VISCERAL
   OBESITY; OXIDATIVE STRESS
AB Recent studies indicate that aldosterone/mineralocorticoid receptor (MR) is a major contributor of chronic kidney disease (CKD) progression. Aldosterone/MR induces glomerular podocyte injury, causing the disruption of the glomerular filtration barrier and proteinuria. Conversely, MR antagonists substantially reduce proteinuria, which can be partly attributable to the protective effects on podocytes. Aldosterone excess, caused by adipocyte-derived aldosterone-releasing factors and other mechanisms, can be pathologically important in the renal complication of metabolic syndrome. A rat model of metabolic syndrome exhibits podocyte injury and proteinuria with serum aldosterone elevation, and the renal damage is prevented by MR blockade. Accumulating data also indicate that MR inhibition can confer renoprotection in a subgroup with low or normal aldosterone levels. We have recently identified the cross-talk between MR and small GTPase Rac1, providing one theoretical basis for the renoprotective effects of MR antagonists in non-high-aldosterone subjects. MR blockade can be a promising strategy for preventing CKD progression, and future clinical trials will conclusively determine the efficacy and tolerability of selective MR inhibition in CKD and metabolic syndrome. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
C1 [Fujita, Toshiro] Univ Tokyo, Grad Sch Med, Dept Nephrol & Endocrinol, Bunkyo Ku, Tokyo 1138655, Japan.
C3 University of Tokyo
RP Fujita, T (corresponding author), Univ Tokyo, Grad Sch Med, Dept Nephrol & Endocrinol, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1138655, Japan.
EM fujita-dis@h.u-tokyo.ac.jp
OI Shibata, Shigeru/0000-0002-6868-0626
FU Grants-in-Aid for Scientific Research [24659410] Funding Source: KAKEN
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NR 74
TC 25
Z9 25
U1 0
U2 11
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0303-7207
J9 MOL CELL ENDOCRINOL
JI Mol. Cell. Endocrinol.
PD MAR 24
PY 2012
VL 350
IS 2
SI SI
BP 273
EP 280
DI 10.1016/j.mce.2011.07.018
PG 8
WC Cell Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Endocrinology & Metabolism
GA 902DY
UT WOS:000301020000016
PM 21820485
DA 2025-06-11
ER

PT J
AU Yu, LM
   Zhou, HY
   Li, JM
   Yu, XL
AF Yu, Liangmeng
   Zhou, Huiyue
   Li, Jiamei
   Yu, Xiaoling
TI Shift work sleep disorder in nurses: a concept analysis
SO BMC NURSING
LA English
DT Review
DE Concept analysis; Shift work; Sleep disorder; Nurses
ID METABOLIC SYNDROME; NIGHT WORKERS; MENTAL-HEALTH; QUALITY; CONSEQUENCES
AB AimThis study seeks to elucidate the concept of shift work sleep disorder (SWSD) among nurses, thereby offering a comprehensive understanding that can inform future research and practical interventions.MethodsWalker and Avant's concept analysis method was employed to guide the study. A systematic literature review was conducted utilizing various databases, including PubMed, Embase, EBSCO, Web of Science, CNKI, WanFang, and Sino Med. The inclusion criteria were specifically designed to focus on studies that define SWSD, along with its attributes, antecedents, consequences, and assessment tools relevant to nursing professionals.ResultsThe analysis identified four key attributes of SWSD: internal/external circadian rhythm imbalance, impaired sleep, multidimensional health problems, and dynamic changes in symptoms. Antecedents include individual factors like personal health, lifestyle, family support, shift patterns, work environment, and other organizational factors. Consequences of SWSD encompass physiological health issues, mental health challenges, impaired social adaptability, and decreased nursing performance.ConclusionSWSD has a significant impact on the health and performance of nurses. Understanding its attributes, antecedents, and consequences is crucial for developing targeted interventions. Enhancing sleep hygiene, fostering supportive work environments, and implementing appropriate shift scheduling can help mitigate the adverse effects associated with SWSD.
C1 [Yu, Liangmeng; Li, Jiamei; Yu, Xiaoling] Zhejiang Univ, Affiliated Hosp 2, Sch Med, Dept Nursing, Hangzhou 310000, Peoples R China.
   [Zhou, Huiyue] Ninth Peoples Hosp Zhengzhou, Zhengzhou, Henan, Peoples R China.
C3 Zhejiang University
RP Yu, XL (corresponding author), Zhejiang Univ, Affiliated Hosp 2, Sch Med, Dept Nursing, Hangzhou 310000, Peoples R China.
EM 2191022@zju.edu.cn
RI Zhou, Huiyue/JCD-4407-2023
OI Zhou, Huiyue/0000-0003-0349-2293
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NR 55
TC 0
Z9 0
U1 12
U2 12
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1472-6955
J9 BMC NURS
JI BMC Nurs.
PD JAN 7
PY 2025
VL 24
IS 1
AR 18
DI 10.1186/s12912-024-02651-z
PG 11
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA R7D1S
UT WOS:001393002000007
PM 39773482
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Dhillon, G
   Buddhavarapu, V
   Grewal, H
   Sharma, P
   Verma, RK
   Munjal, R
   Devadoss, R
   Kashyap, R
AF Dhillon, Gagandeep
   Buddhavarapu, Venkata
   Grewal, Harpreet
   Sharma, Pranjal
   Verma, Ram Kishun
   Munjal, Ripudaman
   Devadoss, Ramprakash
   Kashyap, Rahul
TI Hydrogen Water: Extra Healthy or a Hoax?-A Systematic Review
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE hydrogen water; hydrogenated water; hydrogen-rich water; antioxidant;
   anti-apoptotic; anti-inflammatory
ID RICH WATER; MOLECULAR-HYDROGEN; METABOLIC SYNDROME; BODY-COMPOSITION;
   DOUBLE-BLIND; SUPPLEMENTATION; MEDICINE; PERFORMANCE; COVID-19; GLUCOSE
AB Hydrogen-rich water (HRW) has emerged as a novel approach in the field of health and wellness. It is believed to have therapeutic antioxidant properties that can neutralize harmful free radicals in the human body. It has also been shown to be beneficial in mitigating oxidative stress-induced damage through its anti-inflammatory and anti-apoptotic pathways. We aim to conduct a systematic review to evaluate the potential benefits of hydrogen-rich water. The review protocol was uploaded on PROSPERO. After the initial search criteria, the articles were reviewed by two blinded investigators, and a total of 25 articles were included in the systematic review. The potential benefits of hydrogen-rich water on various aspects of health, including exercise capacity, physical endurance, liver function, cardiovascular disease, mental health, COVID-19, oxidative stress, and anti-aging research, are a subject of growing interest and ongoing research. Although preliminary results in clinical trials and studies are encouraging, further research with larger sample sizes and rigorous methodologies is needed to substantiate these findings. Current research needs to fully explain the mechanisms behind the potential benefits of hydrogen-rich water. Continued scientific exploration will provide valuable insights into the potential of hydrogen-rich water as an adjunctive therapeutic approach in the future.
C1 [Dhillon, Gagandeep] Univ Maryland Baltimore, Washington Med Ctr, Dept Neurol, Glen Burnie, MD 21061 USA.
   [Buddhavarapu, Venkata] Banner Hlth, Banner Med Grp, Phoenix, AZ 85206 USA.
   [Grewal, Harpreet] Florida State Univ, Dept Radiol, Sch Med, Pensacola, FL 32514 USA.
   [Sharma, Pranjal] Northeast Ohio Med Univ, Dept Internal Med, Rootstown, OH 44272 USA.
   [Verma, Ram Kishun] Parkview Hlth Syst, Dept Sleep Med, Ft Wayne, IN 46845 USA.
   [Munjal, Ripudaman] Touro Univ, Dept Nephrol, Coll Osteopath Med, Vallejo, CA 94592 USA.
   [Devadoss, Ramprakash] Carle Methodist Med Ctr, Intervent Cardiol, Peoria, IL 61636 USA.
   [Kashyap, Rahul] WellSpan Hlth, Dept Res, York, PA 17403 USA.
C3 University System of Maryland; University of Maryland Baltimore; Banner
   Research; Banner Health; State University System of Florida; Florida
   State University; University System of Ohio; Northeast Ohio Medical
   University (NEOMED); Touro University California
RP Dhillon, G (corresponding author), Univ Maryland Baltimore, Washington Med Ctr, Dept Neurol, Glen Burnie, MD 21061 USA.
EM gagandeep.dhillon@umm.edu; venkatabuddhavarapu@gmail.com;
   harpreetsinghgrewal@gmail.com; sharma.pranjalmd@gmail.com;
   vermark2006@gmail.com; ripudaman.munjal@gmail.com;
   ramprakash2000@gmail.com; kashyapmd@gmail.com
RI Grewal, Harpreet/AAT-1686-2020; Devadoss, Ramprakash/JRY-5788-2023;
   Dhillon, Gagandeep/HTM-6031-2023; Munjal, Ripudaman Singh/IZQ-2981-2023;
   Kashyap, Rahul/AEM-3686-2022
OI Munjal, Ripudaman Singh/0000-0002-0728-6625; Kashyap,
   Rahul/0000-0002-4383-3411; Buddhavarapu, Venkata/0009-0006-9312-8979;
   Dhillon, Gagandeep/0000-0002-4780-0537; Sharma,
   Pranjal/0009-0002-2301-8441
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NR 50
TC 11
Z9 11
U1 8
U2 37
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD JAN
PY 2024
VL 25
IS 2
AR 973
DI 10.3390/ijms25020973
PG 12
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA GG1G7
UT WOS:001151414700001
PM 38256045
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Panchal, SK
   Poudyal, H
   Iyer, A
   Nazer, R
   Alam, MA
   Diwan, V
   Kauter, K
   Sernia, C
   Campbell, F
   Ward, L
   Gobe, G
   Fenning, A
   Brown, L
AF Panchal, Sunil K.
   Poudyal, Hemant
   Iyer, Abishek
   Nazer, Reeza
   Alam, Md Ashraful
   Diwan, Vishal
   Kauter, Kathleen
   Sernia, Conrad
   Campbell, Fiona
   Ward, Leigh
   Gobe, Glenda
   Fenning, Andrew
   Brown, Lindsay
TI High-carbohydrate High-fat Diet-induced Metabolic Syndrome and
   Cardiovascular Remodeling in Rats
SO JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
LA English
DT Article
DE metabolic syndrome; obesity; cardiovascular disease; hypertension;
   dyslipidemia; high-carbohydrate; high-fat diet
ID OXIDATIVE STRESS; INSULIN-RESISTANCE; HYDROGEN-PEROXIDE;
   CARDIAC-HYPERTROPHY; HYPERTENSIVE-RATS; SMOOTH-MUSCLE; DISEASE;
   MECHANISMS; FRUCTOSE; OBESITY
AB The prevalence of metabolic syndrome including central obesity, insulin resistance, impaired glucose tolerance, hypertension, and dyslipidemia is increasing. Development of adequate therapy for metabolic syndrome requires an animal model that mimics the human disease state. Therefore, we have characterized the metabolic, cardiovascular, hepatic, renal, and pancreatic changes in male Wistar rats (8-9 weeks old) fed on a high-carbohydrate, high-fat diet including condensed milk (39.5%), beef tallow (20%), and fructose (17.5%) together with 25% fructose in drinking water; control rats were fed a cornstarch diet. During 16 weeks on this diet, rats showed progressive increases in body weight, energy intake, abdominal fat deposition, and abdominal circumference along with impaired glucose tolerance, dyslipidemia, hyperinsulinemia, and increased plasma leptin and malondialdehyde concentrations. Cardiovascular signs included increased systolic blood pressure and endothelial dysfunction together with inflammation, fibrosis, hypertrophy, increased stiffness, and delayed repolarization in the left ventricle of the heart. The liver showed increased wet weight, fat deposition, inflammation, and fibrosis with increased plasma activity of liver enzymes. The kidneys showed inflammation and fibrosis, whereas the pancreas showed increased islet size. In comparison with other models of diabetes and obesity, this diet-induced model more closely mimics the changes observed in human metabolic syndrome.
C1 [Panchal, Sunil K.; Kauter, Kathleen; Brown, Lindsay] Univ So Queensland, Dept Biol & Phys Sci, Toowoomba, Qld 4350, Australia.
   [Poudyal, Hemant; Iyer, Abishek; Nazer, Reeza; Alam, Md Ashraful; Diwan, Vishal; Sernia, Conrad; Brown, Lindsay] Univ Queensland, Sch Biomed Sci, Brisbane, Qld, Australia.
   [Campbell, Fiona] Univ Queensland, Sch Vet Sci, Brisbane, Qld, Australia.
   [Ward, Leigh] Univ Queensland, Sch Chem & Mol Biosci, Brisbane, Qld, Australia.
   [Gobe, Glenda] Univ Queensland, Ctr Kidney Dis Res, Sch Med, Brisbane, Qld, Australia.
   [Fenning, Andrew] Cent Queensland Univ, Fac Sci Engn & Hlth, Rockhampton, Qld 4702, Australia.
C3 University of Southern Queensland; University of Queensland; University
   of Queensland; University of Queensland; University of Queensland;
   Central Queensland University
RP Brown, L (corresponding author), Univ So Queensland, Dept Biol & Phys Sci, Toowoomba, Qld 4350, Australia.
EM Lindsay.Brown@usq.edu.au
RI Alam, Ashraful/G-1964-2014; Ward, Leigh/L-4461-2019; Gobe,
   Glenda/G-2315-2010; Poudyal, Hemant/HOH-9324-2023; Ward,
   Leigh/A-4834-2010; Iyer, Abishek/C-9767-2017
OI Kauter, Kate/0000-0003-2470-9172; Ward, Leigh/0000-0003-2378-279X;
   Panchal, Sunil K/0000-0001-5464-3376; Iyer, Abishek/0000-0001-9533-5265
FU Prince Charles Hospital Foundation, Brisbane, Queensland, Australia; Red
   Nutraceuticals, Mt. Nebo, Queensland, Australia
FX Supported partially by grants from The Prince Charles Hospital
   Foundation, Brisbane, Queensland, Australia.We thank Mr. Greg Jardine,
   Dr. Red Nutraceuticals, Mt. Nebo, Queensland, Australia, for financial
   support to allow this project to be undertaken.
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NR 78
TC 335
Z9 359
U1 0
U2 66
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0160-2446
EI 1533-4023
J9 J CARDIOVASC PHARM
JI J. Cardiovasc. Pharmacol.
PD JAN
PY 2011
VL 57
IS 1
BP 51
EP 64
DI 10.1097/FJC.0b013e3181feb90a
PG 14
WC Cardiac & Cardiovascular Systems; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Pharmacology & Pharmacy
GA 705YY
UT WOS:000286178000008
PM 20966763
DA 2025-06-11
ER

PT J
AU Konstandi, M
   Kypreos, KE
   Matsubara, T
   Xepapadaki, E
   Shah, YM
   Krausz, K
   Andriopoulou, CE
   Kofinas, A
   Gonzalez, FJ
AF Konstandi, Maria
   Kypreos, Kyriakos E.
   Matsubara, Tsutomu
   Xepapadaki, Eva
   Shah, Yatrik M.
   Krausz, Kristopher
   Andriopoulou, Christina E.
   Kofinas, Aristeidis
   Gonzalez, Frank J.
TI Adrenoceptor-related decrease in serum triglycerides is independent of
   PPARα activation
SO FEBS JOURNAL
LA English
DT Article
DE adrenergic receptors; hypertriglyceridemia; PPAR alpha; triglycerides;
   TRLs
ID FATTY LIVER-DISEASE; APOLIPOPROTEIN-E; PSYCHOLOGICAL STRESS; IN-VIVO;
   LIPID-METABOLISM; NERVOUS-SYSTEM; GENE; CHOLESTEROL; ANGPTL3; OBESITY
AB Adrenoceptor (AR)-linked pathways belong to the major components of the stress response system and are associated with the pathophysiology of diseases within the spectrum of metabolic syndrome. In this study, the role of adrenoceptor stimulation in serum triglyceride (TG) regulation in mice was investigated. For this purpose, alpha(1)-ARs were activated with phenylephrine (PH) and beta(1/2)-ARs with isoprenaline (ISOP). Both AR agonists markedly reduced serum TG levels independently of PPAR alpha activation. These drugs also significantly activated the hormone-sensitive lipase in the white adipose tissue indicating increased mobilization of TGs in this tissue. In addition, PH and ISOP up-regulated Lpl, Nr4A, Dgat1, Mttp, Aadac and Cd36 genes, critical in TG regulation, whereas the observed decrease in serum TG levels was independent of the hepatic very low-density lipoprotein (VLDL)-TG secretion. Interestingly, PH and ISOP also inactivated the hepatic insulin/PI3k/AKT/FoxO1 signaling pathway, holding a critical role in the regulation of genes involved in TG synthesis. Taken together, the findings of the present study indicate that stimulation of alpha(1)- and beta(1/2)-ARs markedly reduced serum TG steady-state levels as a result of alterations in TG synthesis, uptake, transport, hydrolysis, metabolism and clearance, an effect induced by PPAR alpha independent mechanisms.
C1 [Konstandi, Maria; Andriopoulou, Christina E.; Kofinas, Aristeidis] Univ Ioannina, Fac Med, Dept Pharmacol, Ioannina, Greece.
   [Konstandi, Maria; Matsubara, Tsutomu; Shah, Yatrik M.; Krausz, Kristopher; Gonzalez, Frank J.] NCI, Lab Metab, NIH, Bethesda, MD 20892 USA.
   [Kypreos, Kyriakos E.; Xepapadaki, Eva] Univ Patras, Fac Med, Dept Pharmacol, Rion, Greece.
   [Matsubara, Tsutomu] Osaka City Univ, Grad Sch Med, Dept Anat & Regenerat Biol, Osaka, Japan.
   [Shah, Yatrik M.] Univ Michigan, Sch Med, Dept Mol & Integrat Physiol, Ann Arbor, MI USA.
C3 University of Ioannina; National Institutes of Health (NIH) - USA; NIH
   National Cancer Institute (NCI); University of Patras; Osaka
   Metropolitan University; University of Michigan System; University of
   Michigan
RP Konstandi, M (corresponding author), Univ Ioannina, Fac Med, Sch Hlth Sci, Dept Pharmacol, GR-45110 Ioannina, Greece.
EM mkonstan@uoi.gr
RI KYPREOS, KYRIAKOS/AAN-4485-2020; Gonzalez, Francisco/GWV-3999-2022
OI Gonzalez, Frank/0000-0002-7990-2140
FU European Union (European Regional Development Fund-ERDF); Greek national
   funds through the Operational Program 'THESSALY-MAINLAND GREECE AND
   EPIRUS-2007-2013' of the National Strategic Reference Framework (NSRF
   2007-2013) [346985/80753]; National Cancer Institute Intramural Research
   Program
FX We would like to thank Dr Foteini Malliou for her valuable support and
   technical assistance. This research project has been co-financed by the
   European Union (European Regional Development Fund-ERDF) and Greek
   national funds through the Operational Program 'THESSALY-MAINLAND GREECE
   AND EPIRUS-2007-2013' of the National Strategic Reference Framework
   (NSRF 2007-2013, Grant 346985/80753) and the National Cancer Institute
   Intramural Research Program.
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NR 54
TC 6
Z9 7
U1 1
U2 9
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-464X
EI 1742-4658
J9 FEBS J
JI FEBS J.
PD NOV
PY 2019
VL 286
IS 21
BP 4328
EP 4341
DI 10.1111/febs.14966
EA JUN 2019
PG 14
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA JJ0DU
UT WOS:000474063100001
PM 31230416
OA Bronze, Green Published, Green Accepted
DA 2025-06-11
ER

PT J
AU Dao, J
   Saran, S
   Wang, M
   Michael, C
   Phan, NY
   Bellon, A
AF Dao, Joseph
   Saran, Savreen
   Wang, Melody
   Michael, Christina
   Phan, Nhu-y
   Bellon, Alfredo
TI A Systematic Review on the Potential of Aspirin to Reduce Cardiovascular
   Risk in Schizophrenia
SO BRAIN SCIENCES
LA English
DT Review
DE schizophrenia; aspirin; cardiovascular; anti-inflammatory;
   mental-health; metabolic
ID SEROTONIN REUPTAKE INHIBITORS; SEVERE MENTAL-ILLNESS; SEVERE
   DYSLIPIDEMIA; LIFE EXPECTANCY; DRUG-NAIVE; MORTALITY; ASSOCIATION;
   DISEASES; LOST
AB Cardiovascular disease (CVD), including heart disease and stroke, continues to be the leading cause of death worldwide. Patients with mental health disorders, including schizophrenia (SCZ) are known to have an increased risk for CVD. Given the association with metabolic syndrome, patients with SCZ are often prescribed metformin and statins but its impact remains unsatisfactory. The use of aspirin (ASA) to decrease cardiovascular risk in the general population has been thoroughly investigated and clear guidelines are currently in place. Since adjuvant treatment with ASA could possibly decrease CVD risk and mortality in SCZ, we conducted a systematic review of the literature to determine the state of the current literature on this subject. Our systematic review points to gaps in the literature on CVD prevention in SCZ and illustrates an obvious need for further research. Although several studies have shown increased CVD risk in SCZ, to date, no research has been conducted on the utilization of CVD preventative treatment such as ASA for SCZ.
C1 [Dao, Joseph; Saran, Savreen; Wang, Melody; Michael, Christina; Phan, Nhu-y] Penn State Univ, Coll Med, Hershey, PA 17033 USA.
   [Bellon, Alfredo] Penn State Milton S Hershey Med Ctr, Dept Psychiat & Behav Hlth, Hershey, PA 17033 USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE);
   Pennsylvania State University; Penn State Health; Pennsylvania
   Commonwealth System of Higher Education (PCSHE); Pennsylvania State
   University; Penn State Health
RP Bellon, A (corresponding author), Penn State Milton S Hershey Med Ctr, Dept Psychiat & Behav Hlth, Hershey, PA 17033 USA.
EM abellon@pennstatehealth.psu.edu
OI Saran, Savreen/0000-0003-2418-1582; Bellon, Alfredo/0000-0003-2669-084X
FU Ling and Esther Tan Early Career Professor Award; Department of
   Psychiatry and Behavioral Health, Penn State Hershey Medical Center
FX This work was financially supported by the Ling and Esther Tan Early
   Career Professor Award given to AB by the Department of Psychiatry and
   Behavioral Health, Penn State Hershey Medical Center.
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NR 54
TC 4
Z9 4
U1 0
U2 22
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3425
J9 BRAIN SCI
JI Brain Sci.
PD FEB
PY 2023
VL 13
IS 2
AR 368
DI 10.3390/brainsci13020368
PG 9
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 9H6DY
UT WOS:000938922600001
PM 36831911
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Ezell, JM
   Cabassa, LJ
   Siantz, E
AF Ezell, Jerel M.
   Cabassa, Leopoldo J.
   Siantz, Elizabeth
TI Contours of Usual Care: Meeting the Medical Needs of Diverse People with
   Serious Mental Illness
SO JOURNAL OF HEALTH CARE FOR THE POOR AND UNDERSERVED
LA English
DT Article
DE Serious mental illness; medical care; care coordination; chronic
   disease; qualitative research
ID CORONARY-HEART-DISEASE; QUALITY-OF-CARE; METABOLIC SYNDROME;
   PHYSICAL-ACTIVITY; HEALTH-SERVICES; CARDIOVASCULAR-DISEASE; PERCEIVED
   BARRIERS; ADULTS; SCHIZOPHRENIA; INTERVENTIONS
AB Purpose. To examine practices, barriers, and recommendations for addressing the physical health of racially and ethnically diverse people with serious mental illness (SMI). Methods. Semi-structured interviews and participant observations were conducted with 21 administrators and 25 clinicians representing six mental health care organizations. Data were analyzed using constant comparative methods. Results. Practices included intermittently collecting consumers' physical health data, connecting consumers with primary care, and providing on-site, culturally-tailored health promotion programs. Barriers included limited care coordination infrastructure, financial and professional boundaries, unhealthy local environments and culturally-specific dietary habits. Recommendations included: strengthening dialogue with medical providers and developing staff training programs. Conclusion. Meeting the physical health needs of diverse consumers with SMI is impeded by organizational, environmental, and consumer-level barriers. Establishing better care coordination networks, increasing mental health provider education on medical issues, and culturally-tailoring health promotion programming provide plausible strategies for improving the physical health of this vulnerable population.
C1 [Ezell, Jerel M.] Henry Ford Hosp, Dept Publ Hlth Sci, Detroit, MI 48202 USA.
   [Cabassa, Leopoldo J.] Columbia Univ, Sch Social Work, New York, NY 10027 USA.
   [Siantz, Elizabeth] Univ So Calif, Sch Social Work, Los Angeles, CA 90089 USA.
C3 Henry Ford Health System; Henry Ford Hospital; Columbia University;
   University of Southern California
RP Ezell, JM (corresponding author), Henry Ford Hosp, 1 Ford Pl, Detroit, MI 48202 USA.
EM jezell1@hfhs.org
RI Ezell, Jerel/K-4527-2019
OI Siantz, Elizabeth/0000-0001-8305-3818; Ezell, Jerel/0000-0002-9884-7909
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NR 79
TC 14
Z9 15
U1 0
U2 10
PU JOHNS HOPKINS UNIV PRESS
PI BALTIMORE
PA JOURNALS PUBLISHING DIVISION, 2715 NORTH CHARLES ST, BALTIMORE, MD
   21218-4363 USA
SN 1049-2089
EI 1548-6869
J9 J HEALTH CARE POOR U
JI J. Health Care Poor Underserved
PD NOV
PY 2013
VL 24
IS 4
BP 1552
EP 1573
PG 22
WC Health Policy & Services; Public, Environmental & Occupational Health
WE Social Science Citation Index (SSCI)
SC Health Care Sciences & Services; Public, Environmental & Occupational
   Health
GA 251CG
UT WOS:000326904800013
PM 24185152
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Ding, YF
   Wu, MY
   Zheng, HX
   Cheng, RR
   Jiang, DL
   Zhao, HS
   Mao, CQ
   Lu, TL
   Wu, DL
   Zhang, W
AF Ding, Yangfei
   Wu, Mengying
   Zheng, Hanxiao
   Cheng, Ranran
   Jiang, Dongliang
   Zhao, Hongsu
   Mao, Chunqin
   Lu, Tulin
   Wu, Deling
   Zhang, Wei
TI An integrated metabolomic approach to elucidate the mechanism of
   Chrysanthemi Flos processed products in ameliorating metabolic syndrome
SO JOURNAL OF FUNCTIONAL FOODS
LA English
DT Article
DE Chrysanthemi Flos; Metabolic syndrome; Serum metabolomics; Urine
   metabolomics
ID INSULIN-RESISTANCE; OXIDATIVE STRESS
AB As an important medicinal and dietary flower tea, Chrysanthemi Flos has hypotensive, hypolipidemic and hypoglycaemic benefits. This study investigated the effects of two types of processed Chrysanthemi Flos products-oven-dried Chrysanthemi Flos (DCF) and shade-dried Chrysanthemi Flos (SCF)-on rats with metabolic syndrome (MetS) and their potential mechanisms of action. The pharmacodynamic analysis showed that DCF and SCF improved hypertension, regulated lipid profiles, and reduced liver and kidney damage. Metabolomics analysis revealed eight metabolites, including L-serine, oxaloacetate and succinate as potential biomarkers for mitigating metabolic disorders in MetS rats. Our findings provide scientific evidence for the integration of Chrysanthemi Flos-based products into clinical dietary interventions, offering insights into the mechanisms through which these products can ameliorate MetS. These results have important implications for the development of functional foods that can improve metabolic health.
C1 [Ding, Yangfei; Wu, Mengying; Zheng, Hanxiao; Cheng, Ranran; Jiang, Dongliang; Zhao, Hongsu; Wu, Deling; Zhang, Wei] Anhui Univ Chinese Med, Sch Pharm, Hefei 230012, Peoples R China.
   [Mao, Chunqin; Lu, Tulin; Zhang, Wei] Nanjing Univ Chinese Med, Coll Pharm, Nanjing 210023, Peoples R China.
   [Ding, Yangfei] MOE Anhui Joint Collaborat Innovat Ctr Qual Improv, Hefei 230012, Peoples R China.
   [Wu, Mengying] Anhui Prov Key Lab Tradit Chinese Med Decoct Piece, Hefei 230012, Peoples R China.
   [Cheng, Ranran] Anhui Univ Chinese Med, Joint Res Ctr Chinese Herbal Med Anhui IHM, Hefei 230012, Peoples R China.
C3 Anhui University of Chinese Medicine; Nanjing University of Chinese
   Medicine; Anhui University of Chinese Medicine
RP Wu, DL; Zhang, W (corresponding author), Anhui Univ Chinese Med, Sch Pharm, Hefei 230012, Peoples R China.; Lu, TL; Zhang, W (corresponding author), Nanjing Univ Chinese Med, Coll Pharm, Nanjing 210023, Peoples R China.
EM aucmctcm@163.com
RI Cheng, Ranran/HGA-8919-2022; Wu, Deling/LMN-6918-2024
OI WEI, ZHANG/0000-0002-4638-7402
FU National Natural Sci- ence Foundation of China [81973485]; Research
   Funds of Joint Research Center for Chinese Herbal Medicine of Anhui of
   IHM [yjzx2023007]; Project for the discovery of the technology of the
   characteristic concoction [GZY-KJS-2022-053]
FX The project was supported by grants from the National Natural Sci- ence
   Foundation of China (No. 81973485) , Research Funds of Joint Research
   Center for Chinese Herbal Medicine of Anhui of IHM (yjzx2023007) , and
   Project for the discovery of the technology of the characteristic
   concoction (stir-frying) (GZY-KJS-2022-053) .
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NR 53
TC 1
Z9 1
U1 14
U2 19
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1756-4646
EI 2214-9414
J9 J FUNCT FOODS
JI J. Funct. Food.
PD JUL
PY 2024
VL 118
AR 106286
DI 10.1016/j.jff.2024.106286
EA JUN 2024
PG 15
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA WD5N0
UT WOS:001252945100001
OA gold
DA 2025-06-11
ER

PT J
AU Ozbagcivan, O
   Ozturk, T
   Akarsu, S
   Ilknur, T
   Fetil, E
AF Ozbagcivan, O.
   Ozturk, T.
   Akarsu, S.
   Ilknur, T.
   Fetil, E.
TI Evaluation of metabolic syndrome and its components in patients with
   rosacea: a cross-sectional, case-control study
SO HONG KONG JOURNAL OF DERMATOLOGY & VENEREOLOGY
LA English
DT Article
DE Cardiovascular risk factors; metabolic syndrome; rosacea
ID ENDOPLASMIC-RETICULUM STRESS; OBESITY
AB Introduction: Previous studies have suggested an association between cardiovascular disease and rosacea. However, there is still a paucity of data regarding its association with metabolic syndrome (MetS). Methods: The components of MetS were evaluated in 100 rosacea patients and 100 controls. Results: MetS was determined in 44% of the rosacea patients and 35% of the controls. Although the difference was not statistically significant (p=0.193), rosacea patients were more likely to have dyslipidaemia (p<0.001), insulin resistance (p=0.035), hypertension (p=0.009), higher atherogenic index (p<0.001) and a higher hypercoagulability (p=0.025) and inflammatory state (p=0.003) compared to controls. Conclusion: The results of this study support that rosacea patients should be screened routinely for the components of MetS such as dyslipidaemia, insulin resistance, hypertension and other cardiovascular risk factors.
C1 [Ozbagcivan, O.; Akarsu, S.; Ilknur, T.; Fetil, E.] Dokuz Eylul Univ, Fac Med, Dept Dermatol, TR-35340 Izmir, Turkey.
   [Ozturk, T.] Dokuz Eylul Univ, Fac Med, Dept Ophthalmol, Izmir, Turkey.
C3 Dokuz Eylul University; Dokuz Eylul University
RP Ozbagcivan, O (corresponding author), Dokuz Eylul Univ, Fac Med, Dept Dermatol, TR-35340 Izmir, Turkey.
RI Ozbagcivan, Ozlem/Q-2291-2019; Ozturk, Taylan/AAC-6680-2019; Akarsu,
   Sevgi/P-6198-2019; İlknur, Turna/P-7439-2019
OI Ozbagcivan, Ozlem/0000-0001-7190-3969
FU Scientific and Technological Research Council of Turkey (TUBITAK)
   [215S061]
FX Funding sources that supported the work: This work was financed by the
   "Scientific and Technological Research Council of Turkey (TUBITAK)"
   under Grant number 215S061.
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Z9 2
U1 0
U2 0
PU MEDCOM LTD
PI CHAI WAN
PA ROOM 504-5, CHEUNG TAT CENTRE, 18 CHEUNG LEE ST, CHAI WAN, HONG KONG
   00000, PEOPLES R CHINA
SN 1814-7453
J9 HONG KONG J DERMATOL
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VL 28
IS 2
BP 55
EP 62
PG 8
WC Dermatology
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SC Dermatology
GA MN0YU
UT WOS:000550574000003
DA 2025-06-11
ER

PT J
AU De Koster, J
   Opsomer, G
AF De Koster, J.
   Opsomer, G.
TI Are modern dairy cows suffering from modern diseases?
SO VLAAMS DIERGENEESKUNDIG TIJDSCHRIFT
LA English
DT Review
ID BODY CONDITION SCORE; INDUCED INSULIN-RESPONSE; ADIPOSE-TISSUE;
   METABOLIC SYNDROME; OXIDATIVE STRESS; ENDOCRINE ORGAN; FATTY LIVER;
   GENE-EXPRESSION; DRY PERIOD; OBESE MICE
AB Overconditioning at calving is one of the most important risk factors for modern dairy cows to develop diverse health problems during the transition period. Currently, the metabolic syndrome gains much attention in human medicine. Research shows that the adipose tissue itself plays a crucial role in the increased susceptibility of obese people to a range of health problems, with cardiovascular disease and type 2 diabetes mellitus as the most important problems. The purpose of the present paper is to describe the human metabolic syndrome and the fat cow syndrome with emphasis on both the similarities and differences. It may lead to a better understanding of the pathophysiology of the fat cow syndrome, giving rise to innovative insights into how to improve the management of modern dairy cows in the transition period.
C1 [De Koster, J.; Opsomer, G.] Univ Ghent, Fac Vet Med, Dept Reprod Obstet & Herd Hlth, Salisburylaan 133, B-9820 Merelbeke, Belgium.
C3 Ghent University
RP De Koster, J (corresponding author), Univ Ghent, Fac Vet Med, Dept Reprod Obstet & Herd Hlth, Salisburylaan 133, B-9820 Merelbeke, Belgium.
EM jenne.dekoster@Ugent.be
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NR 80
TC 11
Z9 11
U1 0
U2 10
PU UNIV GHENT
PI GHENT
PA FACULTY VETERINARY MEDICINE, B-9000 GHENT, BELGIUM
SN 0303-9021
J9 VLAAMS DIERGEN TIJDS
JI Vlaams Diergeneeskd. Tijdschr.
PD MAR-APR
PY 2012
VL 81
IS 2
BP 71
EP 80
DI 10.21825/vdt.v81i2.18361
PG 10
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA 937VS
UT WOS:000303691700002
OA hybrid
DA 2025-06-11
ER

PT J
AU Nazmi, A
   Oliveira, IO
   Victora, CG
AF Nazmi, A.
   Oliveira, I. O.
   Victora, C. G.
TI Correlates of C-reactive protein levels in young adults: a
   population-based cohort study of 3827 subjects in Brazil
SO BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
LA English
DT Article
DE C-reactive protein; inflammation; cohort studies; prospective studies;
   Brazil
ID CARDIOVASCULAR RISK-FACTORS; CORONARY-HEART-DISEASE; INFLAMMATORY
   MARKERS; GENERAL-POPULATION; METABOLIC SYNDROME; SYSTEMIC MARKERS;
   NATIONAL-HEALTH; ASSOCIATION; MEN; NUTRITION
AB The socio-demographic, behavioral and anthropometric correlates of C-reactive protein levels were examined in a representative young adult Brazilian population. The 1982 Pelotas Birth Cohort Study ( Brazil) recruited over 99% of births in the city of Pelotas that year (N = 5914). Individuals belonging to the cohort have been prospectively followed up. In 2004-2005, 77.4% of the cohort was traced, members were interviewed and 3827 individuals donated blood. Analyses of the outcome were based on a conceptual model that differentiated confounders from potential mediators. The following independent variables were studied in relation to levels of C-reactive protein in sex-stratified analyses: skin color, age, family income, education, parity, body mass index, waist circumference, smoking, fat/fiber/alcohol intake, physical activity, and minor psychiatric disorder. Geometric mean (95% confidence interval) C-reactive protein levels for the 1919 males and 1908 females were 0.89 (0.84-0.94) and 1.96 mg/L (1.85-2.09), respectively. Pregnant women and those using oral contraceptive therapies presented the highest C-reactive protein levels and all sub-groups of women had higher levels than men (P < 0.001). Significant associations between C-reactive protein levels were observed with age, socioeconomic indicators, obesity status, smoking, fat and alcohol intake, and minor psychiatric disorder. Associations were stronger at higher levels of C-reactive protein and some associations were sex-specific. We conclude that both distal (socio-demographic) and proximal (anthropometric and behavioral) factors exert strong effects on C-reactive protein levels and that the former are mediated to some degree by the latter.
C1 [Nazmi, A.] Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48104 USA.
   [Oliveira, I. O.] Univ Federal Pelotas, Inst Biol, Dept Fisiol & Farmacol, Pelotas, RS, Brazil.
   [Victora, C. G.] Univ Federal Pelotas, Programa Posgrad Epidemiol, Pelotas, RS, Brazil.
C3 University of Michigan System; University of Michigan; Universidade
   Catolica de Pelotas; Universidade Catolica de Pelotas
RP Nazmi, A (corresponding author), Univ Michigan, Sch Publ Hlth, Dept Epidemiol, 109 Observ St, Ann Arbor, MI 48104 USA.
EM anazmi@gmail.com
RI Victora, Cesar/Y-2455-2019; Victora, Cesar/D-4476-2013; Nazmi,
   Aydin/A-4416-2018
OI Victora, Cesar/0000-0002-2465-2180; Nazmi, Aydin/0000-0002-3650-4222
FU Wellcome Trust Funding Source: Medline
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NR 40
TC 34
Z9 44
U1 0
U2 4
PU ASSOC BRAS DIVULG CIENTIFICA
PI RIBEIRAO PRETO
PA FACULDADE MEDICINA, CASA 10, 14049 RIBEIRAO PRETO, RIBEIRAO PRETO, SP
   14049, BRAZIL
SN 0100-879X
EI 1414-431X
J9 BRAZ J MED BIOL RES
JI Brazilian J. Med. Biol. Res.
PD MAY
PY 2008
VL 41
IS 5
BP 357
EP 367
DI 10.1590/S0100-879X2008000500003
PG 11
WC Biology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics; Research & Experimental
   Medicine
GA 342DE
UT WOS:000258764000003
PM 18545810
OA gold
DA 2025-06-11
ER

PT J
AU Schobersberger, W
   Leichtfried, V
   Mueck-Weymann, M
   Humpeler, E
AF Schobersberger, Wolfgang
   Leichtfried, Veronika
   Mueck-Weymann, Michael
   Humpeler, Egon
TI Austrian Moderate Altitude Studies (AMAS): benefits of exposure to
   moderate altitudes (1,500-2,500 m)
SO SLEEP AND BREATHING
LA English
DT Article
DE Moderate altitude; Health tourism; Metabolic syndrome; Exercise; Hiking;
   AMAS
ID HEART-RATE-VARIABILITY; ENDOTHELIAL PROGENITOR CELLS;
   CORONARY-ARTERY-DISEASE; METABOLIC SYNDROME; EXERCISE; RISK;
   INDIVIDUALS; VACATION; HEALTH
AB Objectives A considerable part of the millions of Alpine tourists suffer from pre-existing diseases (e.g., metabolic syndrome) and high daily stress levels. The main goal of the Austrian Moderate Altitude Study (AMAS) was to investigate (a) the consequences of an active vacation at moderate altitude on the key parameters of the metabolic syndrome (AMAS I) and (b) the effects of a short active vacation on adult progenitor cells, bio-psychological parameters, and heart rate variability (HRV).
   Methods During the AMAS I pilot study (n = 22; 1,700 m a.s.l.) and AMAS I main study (n = 71; 1,700 m a.s.l. and 200 m a.s.l.), the volunteers simulated 3-week coached hiking vacations. For AMAS II, healthy volunteers (n = 13) participated in a 1-week active holiday at 1,700 m.
   Results There were significant improvements of obesity, hypertension, dyslipidemia, and insulin resistance of AMAS I patients after the vacation. In AMAS II participants, we found an increase in circulating endothelial progenitor cells as well as improvements in bio-psychological and HRV parameters.
   Conclusions Active vacations at moderate altitude are associated with a variety of positive health effects in persons with metabolic syndrome and in healthy subjects.
C1 [Schobersberger, Wolfgang; Leichtfried, Veronika; Humpeler, Egon] TILAK Innesbruck, ISAG, A-6060 Hall In Tirol, Austria.
   [Schobersberger, Wolfgang; Leichtfried, Veronika; Humpeler, Egon] UMIT, A-6060 Hall In Tirol, Austria.
   [Mueck-Weymann, Michael] UMIT, Inst Verhaltensmed & Pravent, Hall In Tirol, Austria.
   [Humpeler, Egon] Forschungsinst Urlaubs & Freizeitmed Gesundheitst, Inst Humpeler & Schobersberger, Bregenz, Austria.
RP Schobersberger, W (corresponding author), TILAK Innesbruck, ISAG, Eduard Wallnofer Zentrum 1, A-6060 Hall In Tirol, Austria.
EM wolfgang.schobersberger@uki.at
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NR 35
TC 31
Z9 32
U1 1
U2 9
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1520-9512
EI 1522-1709
J9 SLEEP BREATH
JI Sleep Breath.
PD SEP
PY 2010
VL 14
IS 3
BP 201
EP 207
DI 10.1007/s11325-009-0286-y
PG 7
WC Clinical Neurology; Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Respiratory System
GA 638UX
UT WOS:000280923700005
PM 19669819
DA 2025-06-11
ER

PT J
AU Elks, CM
   Francis, J
AF Elks, Carrie M.
   Francis, Joseph
TI Central Adiposity, Systemic Inflammation, and the Metabolic Syndrome
SO CURRENT HYPERTENSION REPORTS
LA English
DT Article
DE Inflammation; Adipokines; Oxidative stress; Metabolic syndrome
ID INDUCED INSULIN-RESISTANCE; C-REACTIVE PROTEIN; BODY-MASS INDEX; HUMAN
   ADIPOCYTES; WAIST CIRCUMFERENCE; OBESE SUBJECTS; TISSUE; EXPRESSION;
   RATS; ADIPOKINES
AB Metabolic syndrome (MetS) is a constellation of metabolic derangements and underlying factors that significantly increases the risk for developing type 2 diabetes and cardiovascular diseases. MetS is a low-grade inflammatory condition, with systemic inflammation and inflammation of central abdominal fat as contributors. Systemic inflammation in MetS is thought to involve C-reactive protein and some proinflammatory cytokines; the nuclear factor-kappa B pathway also is believed to play a role. Inflammation of central adipose tissue leads to adipokine production, followed by secretion of adipokines into the general circulation to contribute to the overall inflammatory condition. The molecular mechanisms that contribute to this inflammation are still somewhat unclear, but several serine/threonine kinases are known to be involved. Dietary components may also contribute to central adiposity and the inflammation seen in MetS.
C1 [Elks, Carrie M.; Francis, Joseph] Louisiana State Univ, Sch Vet Med, Dept Comparat Biomed Sci, Baton Rouge, LA 70803 USA.
C3 Louisiana State University System; Louisiana State University; Louisiana
   State University School of Veterinary Medicine
RP Francis, J (corresponding author), Louisiana State Univ, Sch Vet Med, Dept Comparat Biomed Sci, 1909 Skip Bertman Dr, Baton Rouge, LA 70803 USA.
EM jfrancis@lsu.edu
RI Elks, Carrie/N-1961-2017; Francis, Joseph/I-4984-2012
OI Francis, Joseph/0000-0002-9502-4579
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NR 49
TC 117
Z9 133
U1 1
U2 11
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1522-6417
EI 1534-3111
J9 CURR HYPERTENS REP
JI Curr. Hypertens. Rep.
PD APR
PY 2010
VL 12
IS 2
BP 99
EP 104
DI 10.1007/s11906-010-0096-4
PG 6
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 596XR
UT WOS:000277719600009
PM 20424938
DA 2025-06-11
ER

PT J
AU Panico, P
   Velasco, M
   Salazar, AM
   Picones, A
   Ortiz-Huidobro, RI
   Guerrero-Palomo, G
   Salgado-Bernabe, ME
   Ostrosky-Wegman, P
   Hiriart, M
AF Panico, Pablo
   Velasco, Myrian
   Salazar, Ana Maria
   Picones, Arturo
   Ortiz-Huidobro, Rosa Isela
   Guerrero-Palomo, Gabriela
   Salgado-Bernabe, Manuel Eduardo
   Ostrosky-Wegman, Patricia
   Hiriart, Marcia
TI Is Arsenic Exposure a Risk Factor for Metabolic Syndrome? A Review of
   the Potential Mechanisms
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Review
DE metabolic syndrome; arsenic; beta-cell; insulin resistance; obesity;
   cardiovascular diseases
ID STIMULATED INSULIN-SECRETION; INTIMA-MEDIA THICKNESS; PANCREATIC
   BETA-CELLS; HIGH-FAT DIET; OXIDATIVE STRESS; GENE-EXPRESSION;
   DRINKING-WATER; GLUCOSE-UPTAKE; ENDOTHELIAL-CELLS; LOW-LEVEL
AB Exposure to arsenic in drinking water is a worldwide health problem. This pollutant is associated with increased risk of developing chronic diseases, including metabolic diseases. Metabolic syndrome (MS) is a complex pathology that results from the interaction between environmental and genetic factors. This condition increases the risk of developing type 2 diabetes, cardiovascular diseases, and cancer. The MS includes at least three of the following signs, central obesity, impaired fasting glucose, insulin resistance, dyslipidemias, and hypertension. Here, we summarize the existing evidence of the multiple mechanisms triggered by arsenic to developing the cardinal signs of MS, showing that this pollutant could contribute to the multifactorial origin of this pathology.
C1 [Panico, Pablo; Velasco, Myrian; Picones, Arturo; Ortiz-Huidobro, Rosa Isela; Salgado-Bernabe, Manuel Eduardo; Hiriart, Marcia] Univ Nacl Autonoma Mexico, Dept Cognit Neurosci, Inst Fisiol Celular, Mexico City, Mexico.
   [Salazar, Ana Maria; Guerrero-Palomo, Gabriela; Ostrosky-Wegman, Patricia] Univ Nacl Autonoma Mexico, Dept Genom Med & Environm Toxicol, Inst Invest Biomed, Mexico City, Mexico.
C3 Universidad Nacional Autonoma de Mexico; Universidad Nacional Autonoma
   de Mexico
RP Hiriart, M (corresponding author), Univ Nacl Autonoma Mexico, Dept Cognit Neurosci, Inst Fisiol Celular, Mexico City, Mexico.
RI ; Hiriart, Marcia/A-3988-2008
OI Velasco, Myrian/0000-0002-9276-1928; Hiriart,
   Marcia/0000-0001-5711-8868; ORTIZ HUIDOBRO, ROSA
   ISELA/0000-0002-9266-6218
FU CONACYT-Fronteras [568492]; PAPIIT-UNAM [IN208720]
FX This work was supported by CONACYT-Fronteras grant #568492 and
   PAPIIT-UNAM grant IN208720.
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NR 241
TC 32
Z9 32
U1 2
U2 15
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD MAY 16
PY 2022
VL 13
AR 878280
DI 10.3389/fendo.2022.878280
PG 24
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 1T3DP
UT WOS:000804614000001
PM 35651975
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Czaja, MJ
AF Czaja, Mark J.
TI JNK regulation of hepatic manifestations of the metabolic syndrome
SO TRENDS IN ENDOCRINOLOGY AND METABOLISM
LA English
DT Review
ID ENDOPLASMIC-RETICULUM STRESS; JUN NH2-TERMINAL KINASE;
   INSULIN-RESISTANCE; FATTY LIVER; NONALCOHOLIC STEATOHEPATITIS;
   SENSITIZES HEPATOCYTES; SIGNAL-TRANSDUCTION; ANIMAL-MODELS; RECEPTOR 4;
   PHOSPHORYLATION
AB Nonalcoholic fatty liver disease (NAFLD) is now recognized as both an important component of the metabolic syndrome and the most prevalent liver disease in the United States. Although the mechanisms for development of steatosis and chronic liver injury in NAFLD remain unclear, recent investigations have indicated that overactivation of c-Jun N-terminal kinase (JNK) is crucial to this process. These findings, together with evidence for the involvement of JNK signaling in other manifestations of the metabolic syndrome such as obesity and insulin resistance, have suggested that JNK could be a novel therapeutic target in this disorder. This review details findings that JNK mediates lipid accumulation and cell injury in fatty liver disease and discusses the possible cellular mechanisms of JNK actions.
C1 [Czaja, Mark J.] Albert Einstein Coll Med, Dept Med, Marion Bessin Liver Res Ctr, Bronx, NY 10461 USA.
   [Czaja, Mark J.] Albert Einstein Coll Med, Ctr Diabet Res & Training, Bronx, NY 10461 USA.
C3 Yeshiva University; Montefiore Medical Center; Albert Einstein College
   of Medicine; Yeshiva University; Montefiore Medical Center; Albert
   Einstein College of Medicine
RP Czaja, MJ (corresponding author), Albert Einstein Coll Med, Dept Med, Marion Bessin Liver Res Ctr, 1300 Morris Pk Ave, Bronx, NY 10461 USA.
EM mark.czaja@einstein.yu.edu
FU National Institutes of Health [DK61498]
FX This work was supported by National Institutes of Health Grant DK61498.
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NR 65
TC 107
Z9 109
U1 0
U2 20
PU ELSEVIER SCIENCE LONDON
PI LONDON
PA 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND
SN 1043-2760
EI 1879-3061
J9 TRENDS ENDOCRIN MET
JI Trends Endocrinol. Metab.
PD DEC
PY 2010
VL 21
IS 12
BP 707
EP 713
DI 10.1016/j.tem.2010.08.010
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 694VH
UT WOS:000285326600002
PM 20888782
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Pietrzak, A
   Bartosinska, J
   Hercogová, J
   Lotti, TM
   Chodorowska, G
AF Pietrzak, Aldona
   Bartosinska, Joanna
   Hercogova, Jana
   Lotti, Torello M.
   Chodorowska, Grazyna
TI Metabolic syndrome in vitiligo
SO DERMATOLOGIC THERAPY
LA English
DT Article
DE metabolic abnormalities; oxidative stress; vitiligo
ID ADIPOSE-TISSUE; HOMOCYSTEINE; INFLAMMATION; MELANIN
AB Vitiligo is an acquired, depigmenting skin disease with still unclear, multifactorial etiopathogenesis. However, there is growing evidence that vitiligo affects not only the skin but it may also be connected with metabolic abnormalities, including glucose intolerance and lipid abnormalities, all of which confirms the systemic nature of the disease. Recently, it has been shown that melanocytes, especially those found in the adipose tissue, due to their ability to decrease inflammation and oxidative damage, are capable of preventing the metabolic syndrome. The article presents updated knowledge on potential metabolic disturbances in vitiligo.
C1 [Pietrzak, Aldona; Bartosinska, Joanna; Chodorowska, Grazyna] Med Univ, Dept Dermatol Venereol & Paediat Dermatol, PL-20080 Lublin, Poland.
   [Hercogova, Jana] Charles Univ Prague, Bulovka Univ Hosp, Fac Med 2, Dept Dermatol, Prague, Czech Republic.
   [Lotti, Torello M.] Univ Rome G Marconi, Rome, Italy.
C3 Medical University of Lublin; Motol University Hospital; Bulovka
   University Hospital; Charles University Prague; Guglielmo Marconi
   University
RP Pietrzak, A (corresponding author), Med Univ, Dept Dermatol Venereol & Paediat Dermatol, 13 Radziwillowska St, PL-20080 Lublin, Poland.
EM aldonkapietrzak@o2.pl
RI Bartosińska, Joanna/GOG-8263-2022; Chodorowska, Grazyna/A-2415-2019
OI Pietrzak, Aldona/0000-0001-9494-6160; Bartosinska,
   Joanna/0000-0003-4106-3051; Chodorowska, Grazyna/0000-0002-8055-5764
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NR 15
TC 31
Z9 32
U1 0
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1396-0296
EI 1529-8019
J9 DERMATOL THER
JI Dermatol. Ther.
PD NOV-DEC
PY 2012
VL 25
SU 1
SI SI
BP S41
EP S43
DI 10.1111/dth.12012
PG 3
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 053VW
UT WOS:000312304200006
PM 23237037
DA 2025-06-11
ER

PT J
AU Wang, TX
   Yao, WL
   Shao, YF
   Zheng, RL
   Huang, FR
AF Wang, Tongxin
   Yao, Weilei
   Shao, Yafei
   Zheng, Ruilong
   Huang, Feiruo
TI PCAF fine-tunes hepatic metabolic syndrome, inflammatory disease, and
   cancer
SO JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
LA English
DT Review
DE cancer; fine-tuning; hepatic metabolic syndrome; inflammatory disease;
   PCAF
ID FATTY LIVER-DISEASE; EPITHELIAL-MESENCHYMAL TRANSITION;
   ENDOPLASMIC-RETICULUM STRESS; ACID SYNTHASE GENE;
   HEPATOCELLULAR-CARCINOMA METASTASIS; TRANSCRIPTION FACTOR FOXO1;
   ACTIVATED RECEPTOR-ALPHA; ELEMENT-BINDING PROTEIN; ATP-CITRATE LYASE;
   INSULIN-RESISTANCE
AB The P300/CBP-associating factor (PCAF), a histone acetyltransferase, is involved in metabolic and pathogenic diseases, particularly of the liver. The effects of PCAF on fine-tuning liver diseases are extremely complex and vary according to different pathological conditions. This enzyme has dichotomous functions, depending on differently modified sites, which regulate the activities of various enzymes, metabolic functions, and gene expression. Here, we summarize the most recent findings on the functions and targets of PCAF in various metabolic and immunological processes in the liver and review these new discoveries and models of PCAF biology in three areas: hepatic metabolic syndrome, inflammatory disease, and cancer. Finally, we discuss the potential implications of these findings for therapeutic interventions in liver diseases.
C1 [Wang, Tongxin; Yao, Weilei; Shao, Yafei; Zheng, Ruilong; Huang, Feiruo] Huazhong Agr Univ, Dept Anim Nutr & Feed Sci, Coll Anim Sci & Technol, Wuhan, Hubei, Peoples R China.
C3 Huazhong Agricultural University
RP Huang, FR (corresponding author), Huazhong Agr Univ, Dept Anim Nutr & Feed Sci, Coll Anim Sci & Technol, Wuhan, Hubei, Peoples R China.
EM huangfeiruo@mail.hzau.edu.cn
FU National Natural Science Foundation of China [31572409]; National Key
   Research and Development Program [2016YFD0500506]; Hubei Provincial
   Natural Science Foundation of China [2018CFA071]
FX National Natural Science Foundation of China, Grant/Award Number:
   31572409; National Key Research and Development Program, Grant/Award
   Number: 2016YFD0500506; Hubei Provincial Natural Science Foundation of
   China, Grant/Award Number: 2018CFA071
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NR 133
TC 21
Z9 22
U1 0
U2 13
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
EI 1582-4934
J9 J CELL MOL MED
JI J. Cell. Mol. Med.
PD DEC
PY 2018
VL 22
IS 12
BP 5787
EP 5800
DI 10.1111/jcmm.13877
PG 14
WC Cell Biology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Research & Experimental Medicine
GA HA3HJ
UT WOS:000450140400003
PM 30216660
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU El-Sayed, AM
   Galea, S
AF El-Sayed, Abdulrahman M.
   Galea, Sandro
TI The health of Arab-Americans living in the United States: a systematic
   review of the literature
SO BMC PUBLIC HEALTH
LA English
DT Article
ID 3RD NATIONAL-HEALTH; NUTRITION EXAMINATION SURVEY; MENTAL-HEALTH;
   RISK-FACTORS; ACCULTURATIVE STRESS; NEIGHBORHOOD CONTEXT; METABOLIC
   SYNDROME; SMOKING-BEHAVIOR; HEART-DISEASE; US ADULTS
AB Background: Despite substantial attention paid to Arab-Americans (AAs) in the media and in public discourse, there is limited research about the health of AAs in the United States ( US) in the public health literature. This review aims to synthesize the extant peer-reviewed literature concerned with the health of AAs living in the US.
   Methods: We summarize existing research on the prevalence, relative burden compared to other ethnic and racial groups, and determinants of diseases within each morbidity cluster among AAs living in the US.
   Results: Available evidence suggests that the health of AAs may differ from that of other ethnic and racial groups in the US, and that exposures specific to this ethnic group, such as immigration, acculturation, and discrimination may be important in the etiology of several diseases among AAs.
   Conclusion: Given the growth of this ethnic group and its marginalization in the current sociopolitical climate, more research about the health of AAs in the US seems warranted. We summarize relevant methodological concerns and suggest avenues for future research.
C1 [El-Sayed, Abdulrahman M.; Galea, Sandro] Univ Michigan, Sch Publ Hlth, Ctr Social Epidemiol & Populat Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA.
   [El-Sayed, Abdulrahman M.; Galea, Sandro] Univ Michigan, Sch Med, Ann Arbor, MI USA.
   [Galea, Sandro] Univ Michigan, Inst Social Res, Survey Res Ctr, Ann Arbor, MI USA.
   [Galea, Sandro] Univ Michigan, Ctr Global Hlth, Ann Arbor, MI USA.
C3 University of Michigan System; University of Michigan; University of
   Michigan System; University of Michigan; University of Michigan System;
   University of Michigan; University of Michigan System; University of
   Michigan
RP El-Sayed, AM (corresponding author), Univ Michigan, Sch Publ Hlth, Ctr Social Epidemiol & Populat Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA.
EM elabdul@umich.edu; sgalea@umich.edu
RI Galea, Sandro/GLR-6066-2022; El-Sayed, Abdulrahman/F-7427-2013
OI Galea, Sandro/0000-0002-7534-0945
FU National Institutes of Health [GM07863, DA022720, MH082729, DA017642,
   MH078152]; National Institute of General Medical Sciences [T32GM007863]
   Funding Source: NIH RePORTER
FX This work was supported by the National Institutes of Health [GM07863
   (to AMES), DA022720, MH082729, DA017642, MH078152 (to SG)]. The funding
   organization had no role in the design of this review.
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NR 87
TC 85
Z9 127
U1 0
U2 12
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2458
J9 BMC PUBLIC HEALTH
JI BMC Public Health
PD JUL 30
PY 2009
VL 9
AR 272
DI 10.1186/1471-2458-9-272
PG 9
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA 492NE
UT WOS:000269664400002
PM 19643005
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Hwong, AR
   Chagwedera, DN
   Thomas, M
   Niu, G
   Quan, J
   Vittinghoff, E
   Schillinger, D
   Newcomer, JW
   Gonzalez, A
   Essock, S
   Mangurian, C
AF Hwong, Alison R.
   Chagwedera, D. Nyasha
   Thomas, Marilyn
   Niu, Grace
   Quan, Judy
   Vittinghoff, Eric
   Schillinger, Dean
   Newcomer, John W.
   Gonzalez, Ana
   Essock, Susan
   Mangurian, Christina
TI CRANIUM: a quasi-experimental study to improve metabolic screening and
   HIV testing in community mental health clinics compared to usual care
SO BMC PSYCHIATRY
LA English
DT Article
DE Integrated care; Collaborative care; Serious mental illness; Health care
   disparities; Diabetes
ID COLLABORATIVE CARE; MEDICAL-CARE; RISK-FACTORS; HEPATITIS-B; ILLNESS;
   ADULTS; ANTIPSYCHOTICS; PEOPLE; SCHIZOPHRENIA; PREVALENCE
AB Background Individuals with serious mental illness often do not receive guideline-concordant metabolic screening and human immunodeficiency virus (HIV) testing, contributing to increased morbidity and premature mortality. This study evaluates the effectiveness of CRANIUM (Cardiometabolic Risk Assessment and treatment through a Novel Integration model for Underserved populations with Mental illness), an intervention to increase metabolic screening and HIV testing among patients with serious mental illness in a community mental health clinic compared to usual care. Methods The study used a quasi-experimental design, prospectively comparing a preventive care screening intervention at one community mental health clinic (n = 536 patients) to usual care at the remaining clinics within an urban behavioural health system (n = 4,847 patients). Psychiatrists at the intervention site received training in preventive health screening and had access to a primary care consultant, screening and treatment algorithms, patient registries, and a peer support specialist. Outcomes were the change in screening rates of A1c, lipid, and HIV testing post-intervention at the intervention site compared to usual care sites. Results Rates of lipid screening and HIV testing increased significantly at the intervention site compared to usual care, with and without multivariable adjustment [Lipid: aOR 1.90, 95% CI 1.32-2.75, P = .001; HIV: aOR 23.42, 95% CI 5.94-92.41, P < .001]. While we observed a significant increase in A1c screening rates at the intervention site, this increase did not persist after multivariable adjustment (aOR 1.37, 95% CI .95-1.99, P = .09). Conclusions This low-cost, reverse integrated care model targeting community psychiatrist practices had modest effects on increasing preventive care screenings, with the biggest effect seen for HIV testing rates. Additional incentives and structural supports may be needed to further promote screening practices for individuals with serious mental illness.
C1 [Hwong, Alison R.; Thomas, Marilyn; Gonzalez, Ana; Mangurian, Christina] Univ Calif San Francisco, Dept Psychiat & Behav Sci, San Francisco, CA 94143 USA.
   [Hwong, Alison R.] San Francisco VA Med Ctr, UCSF Natl Clinician Scholars Program, San Francisco, CA 94121 USA.
   [Chagwedera, D. Nyasha] UCSF Sch Med, San Francisco, CA USA.
   [Niu, Grace; Quan, Judy; Vittinghoff, Eric] UCSF, Dept Epidemiol & Biostat, San Francisco, CA USA.
   [Schillinger, Dean; Mangurian, Christina] Zuckerberg San Francisco Gen Hosp, UCSF Ctr Vulnerable Populat, San Francisco, CA USA.
   [Schillinger, Dean] Zuckerberg San Francisco Gen Hosp, UCSF Div Gen Internal Med, San Francisco, CA USA.
   [Newcomer, John W.] Thriving Mind South Florida, Miami, FL USA.
   [Newcomer, John W.; Essock, Susan] Washington Univ, Sch Med, Dept Psychiat, St Louis, MO 63110 USA.
   [Essock, Susan] Columbia Univ, Dept Psychiat, New York, NY USA.
   [Mangurian, Christina] UCSF Philip R Lee Inst Hlth Policy Studies, San Francisco, CA USA.
C3 University of California System; University of California San Francisco;
   US Department of Veterans Affairs; Veterans Health Administration (VHA);
   San Francisco VA Medical Center; University of California System;
   University of California San Francisco; University of California System;
   University of California San Francisco; Washington University (WUSTL);
   Columbia University
RP Hwong, AR (corresponding author), Univ Calif San Francisco, Dept Psychiat & Behav Sci, San Francisco, CA 94143 USA.; Hwong, AR (corresponding author), San Francisco VA Med Ctr, UCSF Natl Clinician Scholars Program, San Francisco, CA 94121 USA.
EM Alison.hwong@ucsf.edu
OI Hwong, Alison/0000-0002-7443-8019
FU National Institutes of Mental Health [K23MH093689, R01MH112420];
   American Psychiatric Association Foundation; National Institutes of
   Mental Health Research Education Grant [R25 MH060482]; NIH Ruth L.
   Kirschstein National Research Service Award [2T32MH018261]; NIH Center
   Grant from the National Institute of Diabetes and Digestive and Kidney
   Diseases for The Health Delivery Systems-Center for Diabetes
   Translational Research (CDTR) [P30DK092924]; NIH/National Institute of
   Minority Health and Health Disparities (NIMHD) Comprehensive Center of
   Excellence for Health and Risk in Minority Youth and Young Adults
   [P60MD006902]; National Institute of Mental Health [T32MH018261,
   R25MH060482, R01MH112420] Funding Source: NIH RePORTER
FX This work was supported by two grants from the National Institutes of
   Mental Health (Mangurian: K23MH093689, R01MH112420). Dr. Hwong receives
   support from the American Psychiatric Association Foundation and a
   National Institutes of Mental Health Research Education Grant (R25
   MH060482). Dr. Niu was supported by the NIH Ruth L. Kirschstein National
   Research Service Award (2T32MH018261). Dr. Schillinger was supported by
   the NIH Center Grant from the National Institute of Diabetes and
   Digestive and Kidney Diseases for The Health Delivery Systems-Center for
   Diabetes Translational Research (CDTR) (P30DK092924) and the
   NIH/National Institute of Minority Health and Health Disparities (NIMHD)
   Comprehensive Center of Excellence for Health and Risk in Minority Youth
   and Young Adults (P60MD006902). The funding bodies played no role in the
   design of the study and collection, analysis, and interpretation of data
   and in writing the manuscript.
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NR 39
TC 3
Z9 3
U1 2
U2 2
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-244X
J9 BMC PSYCHIATRY
JI BMC Psychiatry
PD NOV 9
PY 2022
VL 22
IS 1
AR 687
DI 10.1186/s12888-022-04293-4
PG 8
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychiatry
GA 5Z9ZI
UT WOS:000880322900001
PM 36348280
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Aucoin, M
   LaChance, L
   Clouthier, SN
   Cooley, K
AF Aucoin, Monique
   LaChance, Laura
   Clouthier, Sam N.
   Cooley, Kieran
TI Dietary modification in the treatment of schizophrenia spectrum
   disorders: A systematic review
SO WORLD JOURNAL OF PSYCHIATRY
LA English
DT Review
DE Nutrition; Psychosis; Schizophrenia; Diet
ID SEVERE MENTAL-ILLNESS; QUALITY-OF-LIFE; CARDIOVASCULAR RISK;
   CARDIOMETABOLIC RISK; NEUROTROPHIC FACTOR; PHYSICAL HEALTH; BODY-WEIGHT;
   INTERVENTION; STYLE; PROGRAM
AB BACKGROUND
   Schizophrenia spectrum disorders impact functioning, reduce quality of life and increase the risk of physical illness and premature mortality. Nutritional intervention studies aimed at decreasing body weight have demonstrated efficacy in improving metabolic outcomes; however, few studies have explored the impact of interventions designed to modify diet on mental health outcomes.
   AIM
   To synthesize the existing experimental studies of adjunctive diet modification as an intervention in the treatment of psychotic disorders, analyze findings related to effectiveness and safety, highlight knowledge gaps and limitations, and set forward recommendations for future research studies.
   METHODS
   An extensive a priori search strategy was developed and the databases Embase, Embase Classic, Ovid MEDLINE were searched. Screening and data extraction were completed in duplicate. Studies included in this analysis were experimental studies of an adjunctive dietary intervention (overall dietary pattern or education on dietary change) for treatment of schizophrenia spectrum disorders. No restrictions were placed on control groups or blinding. The studies were required to report a mental health outcome.
   RESULTS
   Twenty-five clinical trials were identified, along with two additional protocols and two meta-analyses. Nineteen of the clinical trials reported improvement in one or more mental health domain including psychosis symptoms, cognition, and quality of life. A high level of heterogeneity was found with respect to patient population, intervention, and study design. All of the studies included lifestyle or psychosocial components in addition to dietary modification. The nutrition advice provided to participants was poorly described overall and compliance was not assessed. The studies that showed benefit tended to have a smaller sample size and were less likely to be randomized but were more likely to use a group delivery intervention.
   CONCLUSION
   Further research assessing effectiveness and efficacy of clearly reported dietary interventions is warranted, especially those using rigorous methodology, modifying diet in isolation and assessing participant compliance.
C1 [Aucoin, Monique; Clouthier, Sam N.; Cooley, Kieran] Canadian Coll Naturopath Med, Dept Res & Clin Epidemiol, 1255 Sheppard Ave E, Toronto, ON M2K 1E2, Canada.
   [LaChance, Laura] McGill Univ, Dept Psychiat, Montreal, PQ H3A 0G4, Canada.
   [LaChance, Laura] Ctr Addict & Mental Hlth, Toronto, ON M6R 1A1, Canada.
   [Cooley, Kieran] Univ Technol Sydney, Australian Res Ctr Complementary & Integrat Med, Dept Publ Hlth, Ultimo 2007, Australia.
   [Cooley, Kieran] Pacific Coll Hlth Sci, Dept Doctoral Acupuncture & Chinese Med, San Diego, CA 92108 USA.
C3 McGill University; University of Toronto; Centre for Addiction & Mental
   Health - Canada; University of Technology Sydney
RP Aucoin, M (corresponding author), Canadian Coll Naturopath Med, Dept Res & Clin Epidemiol, 1255 Sheppard Ave E, Toronto, ON M2K 1E2, Canada.
EM maucoin@ccnm.edu
RI Cooley, Kieran/L-3080-2019; Aucoin, Monique/KHX-8889-2024
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NR 54
TC 23
Z9 26
U1 0
U2 9
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 7041 Koll Center Parkway, Suite 160, PLEASANTON, CA, UNITED STATES
SN 2220-3206
J9 WORLD J PSYCHIATR
JI World J. Psychiatr.
PD AUG 19
PY 2020
VL 10
IS 8
DI 10.5498/wjp.v10.i8.187
PG 16
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA NF8RE
UT WOS:000563559500002
PM 32874956
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Mert, H
   Irak, K
   Çibuk, S
   Yildirim, S
   Mert, N
AF Mert, Handan
   Irak, Kivanc
   Cibuk, Salih
   Yildirim, Serkan
   Mert, Nihat
TI The effect of evening primrose oil (Oenothera biennis) on the
   level of adiponectin and some biochemical parameters in rats with
   fructose induced metabolic syndrome
SO ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
LA English
DT Article
DE Metabolic syndrome; fructose; evening primrose oil; adiponectin;
   oxidant-antioxidant status
ID INDUCED INSULIN-RESISTANCE; ADIPOSE-SPECIFIC PROTEIN; FATTY
   LIVER-DISEASE; OXIDATIVE STRESS; CONSUMPTION; EXPRESSION; INFLAMMATION;
   TISSUE; MODEL; HYPERTENSION
AB The effect of evening primrose oil on adiponectin level and some biochemical parameters in model of fructose-induced metabolic syndrome were investigated. The rats were divided into 4 groups: control, evening primrose oil, fructose, fructose + evening primrose oil. Body weight, daily feed and water consumptions and systolic blood pressures of animals were measured. At the end of trial, blood samples were taken, livers were excised and histopathological examination was performed. Glucose, uric acid, triglyceride, T.cholesterol, LDL, HDL, VLDL, ALT, AST, ALP, LDH, adiponectin, insulin, IL-6, TNF-alpha, TAC, and TOS levels were analysed. Some analysed parameters and systolic blood pressure of fructose + evening primrose oil group decreased significantly compared to fructose group and adiponectin, TAC, and HDL levels were significantly increased. As conclusion, evening primrose oil can be considered as antioxidant agent by reducing oxidative stress, increasing adiponectin levels and insulin sensitivity, anti-inflammatory properties, exhibiting anti-atherogenic effect by regulating dyslipidemia and systolic blood pressure.
C1 [Mert, Handan; Mert, Nihat] Van Yuzuncu Yil Univ, Fac Vet Med, Dept Biochem, Van, Turkey.
   [Irak, Kivanc] Siirt Univ, Fac Vet Med, Dept Biochem, Siirt, Turkey.
   [Cibuk, Salih] Van Yuzuncu Yil Univ, Vocat Sch Hlth Serv, Van, Turkey.
   [Yildirim, Serkan] Ataturk Univ, Fac Vet Med, Dept Pathol, Erzurum, Turkey.
C3 Yuzuncu Yil University; Siirt University; Yuzuncu Yil University;
   Ataturk University
RP Mert, H (corresponding author), Van Yuzuncu Yil Univ, Fac Vet Med, Dept Biochem, Van, Turkey.
EM hg8803@hotmail.com
RI Mert, Handan/AAE-7425-2020; Çibuk, Salih/HDO-8323-2022; Yildirim,
   Serkan/AAH-6721-2020; Mert, Nihat/HJH-5486-2023
OI CIBUK, SALIH/0000-0001-5427-4929
FU Van YYU Directory of Scientific Research Project [TSA-2018-6903]
FX This research was supported by the Van YYU Directory of Scientific
   Research Project under project number TSA-2018-6903.
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NR 68
TC 15
Z9 17
U1 0
U2 9
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1381-3455
EI 1744-4160
J9 ARCH PHYSIOL BIOCHEM
JI Arch. Physiol. Biochem.
PD NOV 2
PY 2022
VL 128
IS 6
BP 1539
EP 1547
DI 10.1080/13813455.2020.1781900
EA JUN 2020
PG 9
WC Biochemistry & Molecular Biology; Biophysics; Endocrinology &
   Metabolism; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Endocrinology &
   Metabolism; Physiology
GA 5L6IA
UT WOS:000549473700001
PM 32594769
DA 2025-06-11
ER

PT J
AU Reccia, I
   Kumar, J
   Akladios, C
   Virdis, F
   Pai, M
   Habib, N
   Spalding, D
AF Reccia, Isabella
   Kumar, Jayant
   Akladios, Cherif
   Virdis, Francesco
   Pai, Madhava
   Habib, Nagy
   Spalding, Duncan
TI Non-alcoholic fatty liver disease: A sign of systemic disease
SO METABOLISM-CLINICAL AND EXPERIMENTAL
LA English
DT Review
DE Fatty liver; NAFLD; NASH; Insulin resistance; Obesity
ID CHRONIC KIDNEY-DISEASE; HEPATIC INSULIN-RESISTANCE; ADIPOSE-TISSUE;
   CARDIOVASCULAR-DISEASE; LIPOPROTEIN-LIPASE; GENE-EXPRESSION;
   NITRIC-OXIDE; MOLECULAR-MECHANISMS; METABOLIC SYNDROME; OXIDATIVE STRESS
AB Non-alcoholic fatty liver disease (NAFLD) is the most common form of liver disease and leading cause of cirrhosis in the United States and developed countries. NAFLD is closely associated with obesity, insulin resistance and metabolic syndrome, significantly contributing to the exacerbation of the latter. Although NAFLD represents the hepatic component of metabolic syndrome, it can also be found in patients prior to their presentation with other manifestations of the syndrome. The pathogenesis of NAFLD is complex and closely intertwined with insulin resistance and obesity. Several mechanisms are undoubtedly involved in its pathogenesis and progression. In this review, we bring together the current understanding of the pathogenesis that makes NAFLD a systemic disease. (C) 2017 Elsevier Inc. All rights reserved.
C1 [Reccia, Isabella; Kumar, Jayant; Akladios, Cherif; Virdis, Francesco; Pai, Madhava; Habib, Nagy; Spalding, Duncan] Imperial Coll London, Hammersmith Hosp, Fac Med, Dept Surg & Canc, London, England.
C3 Imperial College London
RP Reccia, I (corresponding author), Imperial Coll London, Dept Surg & Canc, Fac Med, 1st Floor B Block,Hammersmith Hosp Campus, London W12 0NN, England.
EM isabella.reccia@gmail.com; drjayantsun19@gmail.com;
   cherif.akladios@gmail.com; francesco.virdis@hotmail.it;
   madhava.pai04@imperial.ac.uk; nagy.habib@imperial.ac.uk;
   d.spalding@imperial.ac.uk
RI Pisanu, Francesco/AEJ-1250-2022; Reccia, Isabella/GXZ-6729-2022; Jayant,
   Kumar/I-8106-2019
OI Reccia, Isabella/0000-0003-1194-8828; Akladios,
   Cherif/0000-0001-6189-2741; Kumar, Jayant/0000-0003-0490-7323
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NR 212
TC 144
Z9 159
U1 1
U2 31
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0026-0495
EI 1532-8600
J9 METABOLISM
JI Metab.-Clin. Exp.
PD JUL
PY 2017
VL 72
BP 94
EP 108
DI 10.1016/j.metabol.2017.04.011
PG 15
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA EY9KD
UT WOS:000404316600011
PM 28641788
DA 2025-06-11
ER

PT J
AU Bugger, H
   Abel, ED
AF Bugger, Heiko
   Abel, E. Dale
TI Molecular mechanisms for myocardial mitochondrial dysfunction in the
   metabolic syndrome
SO CLINICAL SCIENCE
LA English
DT Review
DE diabetes; energy metabolism; metabolic syndrome; mitochondrial
   dysfuction; oxidative stress; uncoupling protein (UCP)
ID ACTIVATED RECEPTOR-ALPHA; FATTY-ACID OXIDATION; HUMAN SKELETAL-MUSCLE;
   SARCOPLASMIC-RETICULUM CA2+-ATPASE; NUCLEOTIDE TRANSLOCASE CONTENT;
   NUTRITION EXAMINATION SURVEY; ADIPOSE-TISSUE MITOCHONDRIA; REDUCED
   CARDIAC EFFICIENCY; HUMAN UNCOUPLING PROTEIN-3; GENETICALLY DIABETIC
   MICE
AB The metabolic syndrome represents a cluster of abnormalities, including obesity, insulin resistance, dyslipidaemia and Type 2 diabetes, that increases the risk of developing cardiovascular diseases, such as coronary artery disease and heart failure. The heart failure risk is increased even after adjusting for coronary artery disease and hypertension, and evidence is emerging that changes in cardiac energy metabolism might contribute to the development of contractile dysfunction. Recent findings suggest that myocardial mitochondrial dysfunction may play an important role in the pathogenesis of cardiac contractile dysfunction in obesity, insulin resistance and Type 2 diabetes. This review will discuss potential molecular mechanisms for these mitochondrial abnormalities.
C1 [Bugger, Heiko; Abel, E. Dale] Univ Utah, Sch Med, Program Human Mol Biol & Genet, Div Endocrinol, Salt Lake City, UT 84112 USA.
C3 Utah System of Higher Education; University of Utah
RP Abel, ED (corresponding author), Univ Utah, Sch Med, Program Human Mol Biol & Genet, Div Endocrinol, Salt Lake City, UT 84112 USA.
EM dale.abel@hmbg.utah.edu
RI Bugger, Heiko/ABA-4180-2021
OI Bugger, Heiko/0000-0002-3524-0405; Abel, E. Dale/0000-0001-5290-0738
FU NHLBI NIH HHS [R01 HL73167, UO1HL70525, R01 HL70070, UO1 HL087947]
   Funding Source: Medline
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NR 160
TC 159
Z9 183
U1 0
U2 9
PU PORTLAND PRESS LTD
PI LONDON
PA CHARLES DARWIN HOUSE, 12 ROGER STREET, LONDON WC1N 2JU, ENGLAND
SN 0143-5221
EI 1470-8736
J9 CLIN SCI
JI Clin. Sci.
PD FEB
PY 2008
VL 114
IS 3-4
BP 195
EP 210
DI 10.1042/CS20070166
PG 16
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 261PU
UT WOS:000253093300003
PM 18184113
DA 2025-06-11
ER

PT J
AU Kim, CH
   Younossi, ZM
AF Kim, Chin Hee
   Younossi, Zair M.
TI Nonalcoholic fatty liver disease: A manifestation of the metabolic
   syndrome
SO CLEVELAND CLINIC JOURNAL OF MEDICINE
LA English
DT Review
ID INSULIN-RESISTANCE; CONTROLLED-TRIAL; NATURAL-HISTORY; WEIGHT-LOSS;
   FOLLOW-UP; VITAMIN-E; STEATOHEPATITIS; NAFLD; AMINOTRANSFERASE;
   PREVALENCE
AB Nonalcoholic fatty liver disease (NAFLD) has become the most common form of liver disease, affecting 20% to 30% of the US population. Its clinical manifestations are usually absent or subtle, and it usually comes to medical attention incidentally when aminotransferase levels are found to be elevated or a radiographic study reveals that the liver is fatty. Primary NAFLD is now considered the hepatic manifestation of the metabolic syndrome. The pathogenesis is thought to be a multiple-hit process involving insulin resistance, oxidative stress, apoptosis, and adipokines. In general, the prognosis for simple steatosis is very good; however, nonalcoholic steatohepatitis (NASH) can progress to cirrhosis and hepatocellular carcinoma in 10% to 15% of patients. There is no established treatment for NAFLD except for weight loss and treating each component of the metabolic syndrome.
C1 [Kim, Chin Hee; Younossi, Zair M.] Inova Fairfax Hosp, Ctr Liver Dis, Falls Church, VA 22042 USA.
   [Younossi, Zair M.] Inova Hlth Syst, Falls Church, VA USA.
   [Younossi, Zair M.] Virginia Commonwealth Univ, Richmond, VA 23284 USA.
C3 Inova Fairfax Hospital; Inova Health System; Virginia Commonwealth
   University
RP Younossi, ZM (corresponding author), Inova Fairfax Hosp, Ctr Liver Dis, 3300 Gallows Rd, Falls Church, VA 22042 USA.
EM zobair.younossi@inova.com
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NR 33
TC 275
Z9 312
U1 0
U2 15
PU CLEVELAND CLINIC
PI CLEVELAND
PA 9500 EUCLID AVE, CLEVELAND, OH 44106 USA
SN 0891-1150
EI 1939-2869
J9 CLEV CLIN J MED
JI Clevel. Clin. J. Med.
PD OCT
PY 2008
VL 75
IS 10
BP 721
EP 728
DI 10.3949/ccjm.75.10.721
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 360DI
UT WOS:000260036800006
PM 18939388
DA 2025-06-11
ER

PT J
AU das Merces, MC
   Coelho, JMF
   Lua, I
   Silva, DDE
   Gomes, AMT
   Santana, AIC
   da Silva, DAR
   Magalhaes, LBNC
   D'Oliveira, A
AF Merces, Magno Conceicao das
   Coelho, Julita Maria Freitas
   Lua, Iracema
   Silva, Douglas de Souza e
   Gomes, Antonio Marcos Tosoli
   Santana, Amalia Ivine Costa
   da Silva, Dandara Almeida Reis
   Neves Cunha Magalhaes, Lucelia Batista
   Junior, Argemiro D'Oliveira
TI Burnout syndrome and metabolic syndrome: a cross-sectional
   population-based study
SO ARCHIVES OF ENVIRONMENTAL & OCCUPATIONAL HEALTH
LA English
DT Article
DE Burnout; metabolic syndrome; nursing; occupational health; primary
   health care; professional
ID RISK-FACTOR; HEALTH; ASSOCIATION; PREVALENCE; COMPONENTS; PROGRAM;
   OBESITY; STRESS; AGE
AB In the population of Primary Health Care Nursing (PHC) professionals, the association between Burnout Syndrome (BS) and Metabolic Syndrome (MS) has not been investigated. The objective was to evaluate the association between BS and MS among PHC Nursing Professionals. A cross-sectional, multicenter, population-based study was conducted in the state of Bahia, Brazil, with 1,125 professionals. The prevalence of BS and MS corresponded to 18.3% and 24.4%, respectively. The prevalence in women of BS was 16.4% and of MS 23.7%, in men 31.6% for BS and 29.4% for MS. Men with BS are 3.23 times more likely to develop MS, and women 1.48 times more. BS was associated between men and women and exhibited a good discriminatory predictive power.
C1 [Merces, Magno Conceicao das; Coelho, Julita Maria Freitas; da Silva, Dandara Almeida Reis] Univ Bahia State, Life Sci Dept, Salvador, BA, Brazil.
   [Lua, Iracema] State Univ Feira De Santana UEFS, Dept Hlth, Feira De Santana, BA, Brazil.
   [Silva, Douglas de Souza e; Santana, Amalia Ivine Costa; da Silva, Dandara Almeida Reis; Junior, Argemiro D'Oliveira] Univ Fed Bahia, Hlth Sci Postgrad Program, Sch Med, Salvador, BA, Brazil.
   [Gomes, Antonio Marcos Tosoli] Univ Estado Rio De Janeiro, Biomed Ctr, Sch Nursing, Rio De Janeiro, Brazil.
   [Neves Cunha Magalhaes, Lucelia Batista] Univ Fed Bahia, Hlth Sci Postgrad Program, Sch Med, Dept Family Hlth, Salvador, BA, Brazil.
   [Neves Cunha Magalhaes, Lucelia Batista] UniFTC Univ Ctr, Salvador, BA, Brazil.
C3 Universidade Estadual de Feira de Santana; Universidade Federal da
   Bahia; Universidade do Estado do Rio de Janeiro; Universidade Federal da
   Bahia
RP das Merces, MC (corresponding author), Univ Bahia State, Life Sci Dept, Salvador, BA, Brazil.
EM mmerces@uneb.br
RI MAGALHÃES, LUCELIA/AAA-1378-2019; Gomes, A./Q-6844-2016; Merces,
   Magno/S-6649-2017; Lua, Iracema/AAR-2466-2021
OI Coelho, Julita/0000-0002-9520-5177; Almeida Reis da Silva,
   Dandara/0000-0001-6091-4080; DE SOUZA E SILVA,
   DOUGLAS/0000-0003-4476-7767; Merces, Magno Conceicao
   das/0000-0003-3493-8606
FU State University of Bahia; Feira de Santana State University; Federal
   University of Bahia; State University of Rio de Janeiro; National
   Council for Scientific and Technological Development (CNPq), Brazil
   [408390/2016-6]
FX The authors are grateful to the partnership of the State University of
   Bahia, Feira de Santana State University, Federal University of Bahia
   and State University of Rio de Janeiro for their support in several
   stages of the project, emphasizing the availability of undergraduate and
   postgraduate students for data collection. They also thank the National
   Council for Scientific and Technological Development (CNPq), Brazil, for
   the research funding by means of the Universal Call Notice - protocol
   #408390/2016-6.
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NR 55
TC 9
Z9 9
U1 0
U2 4
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 1933-8244
EI 2154-4700
J9 ARCH ENVIRON OCCUP H
JI Arch. Environ. Occup. Health
PD JUL 4
PY 2021
VL 76
IS 5
BP 266
EP 274
DI 10.1080/19338244.2020.1819186
EA SEP 2020
PG 9
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA TM5YN
UT WOS:000574015200001
PM 33000694
DA 2025-06-11
ER

PT J
AU Li, YT
   Zhao, WY
   Sair, AT
   Li, T
   Liu, RH
AF Li, Yitong
   Zhao, Weiyang
   Sair, Ali Tahir
   Li, Tong
   Liu, Rui Hai
TI Ferulic acid restores mitochondrial dynamics and autophagy via AMPK
   signaling pathway in a palmitate-induced hepatocyte model of metabolic
   syndrome
SO SCIENTIFIC REPORTS
LA English
DT Article
DE Ferulic acid; Metabolic syndrome; Phenolics; Mitochondria; Autophagy;
   Obesity; Diabetes
ID HEPG2 CELLS; FATTY-ACIDS; GLUCOSE; DYSFUNCTION; BIOGENESIS; EXPRESSION
AB Mitochondrial dysfunction, characterized by elevated oxidative stress, impaired energy balance, and dysregulated mitochondrial dynamics, is a hallmark of metabolic syndrome (MetS) and its comorbidities. Ferulic acid (FA), a principal phenolic compound found in whole grains, has demonstrated potential in ameliorating oxidative stress and preserving energy homeostasis. However, the influence of FA on mitochondrial health within the context of MetS remains unexplored. Moreover, the impact of FA on autophagy, which is essential for maintaining energy homeostasis and mitochondrial integrity, is not fully understood. Here, we aimed to study the mechanisms of action of FA in regulating mitochondrial health and autophagy using palmitate-treated HepG2 hepatocytes as a MetS cell model. We found that FA improved mitochondrial health by restoring redox balance and optimizing mitochondrial dynamics, including biogenesis and the fusion/fission ratio. Additionally, FA was shown to recover autophagy and activate AMPK-related cell signaling. Our results provide new insights into the therapeutic potential of FA as a mitochondria-targeting agent for the prevention and treatment of MetS.
C1 [Li, Yitong; Zhao, Weiyang; Sair, Ali Tahir; Li, Tong; Liu, Rui Hai] Cornell Univ, Dept Food Sci, 245 Stocking Hall, Ithaca, NY 14853 USA.
C3 Cornell University
RP Liu, RH (corresponding author), Cornell Univ, Dept Food Sci, 245 Stocking Hall, Ithaca, NY 14853 USA.
EM RL23@cornell.edu
RI Li, Yitong/IQS-0126-2023; Liu, Rui/AAE-4865-2019
FU Dasong Agricultural Technology and YanGuFang Reseearch Laboratory
   [2022-8950]; Cornell China Center
FX The authors thank the Clover Center and Viviana Gradinaru's lab at
   California Institute of Technology for technical support in the imaging
   part. This work was partially supported by Cornell China Center, Dasong
   Agricultural Technology and YanGuFang Research Laboratory (2022-8950).
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NR 84
TC 5
Z9 5
U1 3
U2 5
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD AUG 16
PY 2024
VL 14
IS 1
AR 18970
DI 10.1038/s41598-024-66362-w
PG 15
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA D1T7G
UT WOS:001294085700051
PM 39152139
OA gold
DA 2025-06-11
ER

PT J
AU You, S
   Jang, M
   Kim, GH
AF You, SoHyeon
   Jang, Miran
   Kim, Gun-Hee
TI Mori Cortex radicis extract protected against diet-induced
   neuronal damage by suppressing the AGE-RAGE/MAPK signaling pathway in
   C. elegans and mouse model
SO JOURNAL OF FUNCTIONAL FOODS
LA English
DT Article
DE Metabolic syndrome; Advanced glycation end products; Mori cortex
   radicis; MAPK pathway; Neurodegenerative disease
ID GLYCATION END-PRODUCTS; METABOLIC SYNDROME; HIGH-FAT; OXIDATIVE STRESS;
   CAENORHABDITIS-ELEGANS; WESTERN DIET; HIGH-SUGAR; KAPPA-B; GLUCOSE;
   INFLAMMATION
AB In this study, the underlying mechanisms of metabolic syndrome (MetS) and the risk of AD factors, and the effect of dietary Mori cortex radicis (MCR) were investigated in two in vivo models. In glucose-induced C. elegans, MCR attenuated metabolic disorder by inhibiting lipid and advanced glycation end products (AGEs) production, reducing oxidative stress, and preventing cognition and behavioral deficits. In high fat/liquid sugar-induced MetS mice, MCR intervention improved metabolic alterations and spatial memory. Furthermore, MCR in diet suppressed AGEs deposit and RAGE expression, improved the antioxidant system, and decreased proinflammatory cytokine levels in mouse hippocampus. This was accompanied by downregulation of the MAPK (p38, ERK, and JNK) pathway, which consequently protected against brain damage by suppressing BACE-1, APP, Tau, and A beta. These findings may be valuable for those investigating crosstalk between MetS and neurodegenerative disease progression or the effect of MCR on the AGE-RAGE/MAPK pathway.
C1 [You, SoHyeon; Kim, Gun-Hee] Duksung Womens Univ, Dept Biohlth Convergence, Seoul 01369, South Korea.
   [Jang, Miran] Inje Univ, Dept Food & Life Sci, Gimhae 50834, South Korea.
   [Kim, Gun-Hee] Duksung Womens Univ, Dept Food & Nutr, Seoul 01369, South Korea.
C3 Duksung Women's University; Inje University; Duksung Women's University
RP Kim, GH (corresponding author), Duksung Womens Univ, Dept Biohlth Convergence, Seoul 01369, South Korea.; Kim, GH (corresponding author), Duksung Womens Univ, Dept Food & Nutr, Seoul 01369, South Korea.
EM ush0206@hanmail.net; mrjang@inje.ac.kr; ghkim@duksung.ac.kr
FU National Research Foundation of Korea (NRF) - Korea government (MSIT)
   [2019R1A2C1086146, 2021R1A6A3A13039265]
FX This study was supported by the National Research Foundation of Korea
   (NRF) grant funded by the Korea government (MSIT) (2019R1A2C1086146) and
   (2021R1A6A3A13039265) .
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NR 75
TC 1
Z9 1
U1 2
U2 15
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1756-4646
EI 2214-9414
J9 J FUNCT FOODS
JI J. Funct. Food.
PD APR
PY 2022
VL 91
AR 104996
DI 10.1016/j.jff.2022.104996
EA FEB 2022
PG 11
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA 1J8YD
UT WOS:000798198300002
OA gold
DA 2025-06-11
ER

PT J
AU Massaro, L
   Raguzzini, A
   Aiello, P
   Valencia, DV
AF Massaro, Luca
   Raguzzini, Anna
   Aiello, Paola
   Valencia, Debora Villano
TI The Potential Role of Naringin and Naringenin as Nutraceuticals Against
   Metabolic Syndrome
SO ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS
LA English
DT Review
DE Flavonoids; citrus fruits; anti-inflammatory; naringin; naringenin;
   metabolic syndrome
ID CITRUS FLAVONOIDS; HIGH-FAT; GRAPEFRUIT JUICE; OXIDATIVE STRESS;
   TNF-ALPHA; FLAVANONE NARINGENIN; INSULIN-RESISTANCE; ORANGE JUICE;
   IN-VITRO; TISSUE DISTRIBUTION
AB Metabolic syndrome, an increasing problem in western society, is a cluster of conditions that affect cardiovascular health, lipid and glucose management, increasing the risk of heart diseases, stroke and diabetes. Bioactive flavonoids are a great resource of compounds with proven anti-inflammatory activities. Naringin, a natural flavanone found in citrus fruits, and its aglycone have demonstrated to ameliorate obesity, dyslipidemia, and insulin resistance in animal models. The principal mechanisms by which these flavonoids exert their action involve AMPK and PPAR alpha up-regulation and the down-regulation of genes involved in lipid metabolism. Although different studies have been carried out to define the pharmacological effects of these flavonoids, their therapeutic use is still limited.
C1 [Massaro, Luca; Raguzzini, Anna] Council Agr Res & Econ CREA AN, Res Ctr Food & Nutr, Rome, Italy.
   [Aiello, Paola] Sapienza Univ Rome, Dept Physiol & Pharmacol V Erspamer, Rome, Italy.
   [Aiello, Paola] Univ Catol Murcia UCAM, Hlth Sci PhD Program, Campus Jeronimos 135, Murcia 30107, Spain.
   [Valencia, Debora Villano] Univ Catolica Murcia UCAM, Fac Hlth Sci, Sch Pharm, Nutr & Estres Oxidat & Biodisponibil Res Grp, Campus Jeronimos 135, Murcia 30107, Spain.
C3 Consiglio per la Ricerca in Agricoltura e L'analisi Dell'economia
   Agraria (CREA); Sapienza University Rome; Universidad Catolica de
   Murcia; Universidad Catolica de Murcia
RP Valencia, DV (corresponding author), Univ Catolica Murcia UCAM, Fac Hlth Sci, Sch Pharm, Nutr & Estres Oxidat & Biodisponibil Res Grp, Campus Jeronimos 135, Murcia 30107, Spain.
EM dvillano@ucam.edu
RI Massaro, Luca/KJL-6944-2024; Aiello, Paola/ABG-2531-2021; Villano
   Valencia, Debora/F-1022-2012
OI Aiello, Paola/0000-0001-6136-0294; Massaro, Luca/0000-0001-6370-9787;
   Villano Valencia, Debora/0000-0002-8162-8857
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NR 203
TC 9
Z9 10
U1 2
U2 21
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1871-5303
EI 2212-3873
J9 ENDOCR METAB IMMUNE
JI Endocr. Metab. Immune Disord.-Drug Targets
PY 2023
VL 23
IS 4
BP 428
EP 445
DI 10.2174/1871530322666220827141203
PG 18
WC Endocrinology & Metabolism; Immunology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Immunology; Pharmacology & Pharmacy
GA I8WD8
UT WOS:001005522900003
PM 36043734
DA 2025-06-11
ER

PT J
AU Fowler, SPG
AF Fowler, Sharon P. G.
TI Low-calorie sweetener use and energy balance: Results from experimental
   studies in animals, and large-scale prospective studies in humans
SO PHYSIOLOGY & BEHAVIOR
LA English
DT Article
DE Low-calorie sweeteners; Non-nutritive sweeteners; Diet sodas; Diet
   beverages; Weight; Obesity
ID HIGH-INTENSITY SWEETENERS; CORONARY-HEART-DISEASE; BODY-FAT
   DISTRIBUTION; NEUTRAL AMINO-ACIDS; DIET SODA INTAKE; ARTIFICIAL
   SWEETENERS; WEIGHT-GAIN; BISPHENOL-A; METABOLIC SYNDROME; MONOSODIUM
   GLUTAMATE
AB For more than a decade, pioneering animal studies conducted by investigators at Purdue University have provided evidence to support a central thesis: that the uncoupling of sweet taste and caloric intake by low-calorie sweeteners (LCS) can disrupt an animal's ability to predict the metabolic consequences of sweet taste, and thereby impair the animal's ability to respond appropriately to sweet-tasting foods. These investigators' work has been replicated and extended internationally. There now exists a body of evidence, from a number of investigators, that animals chronically exposed to any of a range of LCSs - including saccharin, sucralose, acesulfame potassium, aspartame, or the combination of erythritol + aspartame - have exhibited one or more of the following conditions: increased food consumption, lower post-prandial thermogenesis, increased weight gain, greater percent body fat, decreased GLP-1 release during glucose tolerance testing, and significantly greater fasting glucose, glucose area under the curve during glucose tolerance testing, and hyperinsulinemia, compared with animals exposed to plain water or - in many cases - even to calorically-sweetened foods or liquids. Adverse impacts of LCS have appeared diminished in animals on dietary restriction, but were pronounced among males, animals genetically predisposed to obesity, and animals with diet-induced obesity. Impacts have been especially striking in animals on high-energy diets: diets high in fats and sugars, and diets which resemble a highly-processed 'Western' diet, including trans-fatty acids and monosodium glutamate.
   These studies have offered both support for, and biologically plausible mechanisms to explain, the results from a series of large-scale, long-term prospective observational studies conducted in humans, in which longitudinal increases in weight, abdominal adiposity, and incidence of overweight and obesity have been observed among study participants who reported using diet sodas and other LCS-sweetened beverages daily or more often at baseline. Furthermore, frequent use of diet beverages has been associated prospectively with increased long-term risk and/or hazard of a number of cardiometabolic conditions usually considered to be among the sequelae of obesity: hypertension, metabolic syndrome, diabetes, depression, kidney dysfunction, heart attack, stroke, and even cardiovascular and total mortality. Reverse causality does not appear to explain fully the increased risk observed across all of these studies, the majority of which have included key potential confounders as covariates. These have included body mass index or waist circumference at baseline; total caloric intake and specific macro nutrient intake; physical activity; smoking; demographic and other relevant risk factors; and/or family history of disease. Whether non-LCS ingredients in diet beverages might have independently increased the weight gain and/or cardiometabolic risk observed among frequent consumers of LCS-sweetened beverages deserves further exploration. In the meantime, however, there is a striking congruence between results from animal research and a number of large-scale, long-term observational studies in humans, in finding significantly increased weight gain, adiposity, incidence of obesity, cardiometabolic risk, and even total mortality among individuals with chronic, daily exposure to low-calorie sweeteners - and these results are troubling. (C) 2016 Elsevier Inc. All rights reserved.
C1 [Fowler, Sharon P. G.] Univ Texas Hlth Sci Ctr San Antonio, Dept Med, San Antonio, TX 78229 USA.
C3 University of Texas System; University of Texas Health Science Center at
   San Antonio
RP Fowler, SPG (corresponding author), Univ Texas Hlth Sci Ctr San Antonio, Dept Med, San Antonio, TX 78229 USA.
EM fowlers@uthscsa.edu
OI Fowler, Sharon/0000-0003-1117-683X
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NR 111
TC 87
Z9 95
U1 3
U2 164
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0031-9384
EI 1873-507X
J9 PHYSIOL BEHAV
JI Physiol. Behav.
PD OCT 1
PY 2016
VL 164
SI SI
BP 517
EP 523
DI 10.1016/j.physbeh.2016.04.047
PN B
PG 7
WC Psychology, Biological; Behavioral Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Behavioral Sciences
GA DV9YH
UT WOS:000383297600023
PM 27129676
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Racette, SB
   Inman, CL
   Clark, BR
   Royer, NK
   Steger-May, K
   Deusinger, SS
AF Racette, Susan B.
   Inman, Cindi L.
   Clark, B. Ruth
   Royer, Nathaniel K.
   Steger-May, Karen
   Deusinger, Susan S.
TI Exercise and Cardiometabolic Risk Factors in Graduate Students: A
   Longitudinal, Observational Study
SO JOURNAL OF AMERICAN COLLEGE HEALTH
LA English
DT Article
DE cardiometabolic; exercise; health behaviors; physical activity
ID PERCEIVED ACADEMIC STRESS; PHYSICAL-ACTIVITY; DIETARY PATTERNS;
   YOUNG-ADULTS; SOCIODEMOGRAPHIC CHARACTERISTICS; ALL-CAUSE; ASSOCIATIONS;
   COLLEGE; ADOLESCENTS; MORTALITY
AB Objective: To evaluate cardiometabolic risk of students longitudinally and compare them with age-matched national samples. Participants: Participants are 134 graduate students enrolled between August 2005 and May 2010. Methods: Students were assessed at the beginning and end of their 3-year curriculum. Comparative samples included 966 National Health and Nutrition Examination Survey participants and 5,154 National College Health Assessment respondents. Results: Most students had desirable weight, blood glucose, lipids, and fitness at both time points. However, 26.9% had elevated blood pressure, 29.9% performed aerobic exercise < 3days/week, and 80.6% consumed < 5 fruits/vegetables daily. Relative to young adults nationwide, these students exhibited more favorable exercise patterns, dietary patterns, and cardiometabolic indices. Over time, increases in adiposity and decreases in exercise frequency correlated with adverse changes in lipid concentrations and fitness. Conclusions: Small changes in lifestyle behaviors and adiposity within a healthy cohort of young adults significantly influenced cardiometabolic indices during their graduate career.
C1 [Racette, Susan B.; Inman, Cindi L.; Clark, B. Ruth; Royer, Nathaniel K.; Deusinger, Susan S.] Washington Univ, Sch Med, Program Phys Therapy, St Louis, MO 63108 USA.
   [Steger-May, Karen] Washington Univ, Sch Med, Dept Biostat, St Louis, MO 63108 USA.
C3 Washington University (WUSTL); Washington University (WUSTL)
RP Racette, SB (corresponding author), Washington Univ, Sch Med, Campus Box 8502,4444 Forest Pk Ave, St Louis, MO 63108 USA.
EM racettes@wustl.edu
RI Racette, Susan/GLS-6669-2022
OI Racette, Susan/0000-0002-6932-1887
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NR 45
TC 8
Z9 14
U1 0
U2 30
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 0744-8481
EI 1940-3208
J9 J AM COLL HEALTH
JI J. Am. Coll. Health
PD JAN 2
PY 2014
VL 62
IS 1
BP 47
EP 56
DI 10.1080/07448481.2013.843535
PG 10
WC Education & Educational Research; Public, Environmental & Occupational
   Health
WE Social Science Citation Index (SSCI)
SC Education & Educational Research; Public, Environmental & Occupational
   Health
GA 269NE
UT WOS:000328247200006
PM 24313696
DA 2025-06-11
ER

PT J
AU Rong, J
   Zhang, ZX
   Peng, XY
   Li, P
   Zhao, TT
   Zhong, YF
AF Rong, Jin
   Zhang, Zixuan
   Peng, Xiaoyu
   Li, Ping
   Zhao, Tingting
   Zhong, Yifei
TI Mechanisms of hepatic and renal injury in lipid metabolism disorders in
   metabolic syndrome
SO INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
LA English
DT Review
DE Metabolic Syndrome; Diabetic Kidney Disease; Non-alcoholic Fatty Liver
   Disease; Lipid Metabolism; Treatment
ID FATTY LIVER-DISEASE; IMPROVES INSULIN SENSITIVITY; GUT MICROBIOTA;
   KIDNEY-DISEASE; X-RECEPTOR; BILE-ACID; NLRP3 INFLAMMASOME; OXIDATIVE
   STRESS; BINDING PROTEIN; STATIN THERAPY
AB Metabolic syndrome (MetS) is a group of metabolic abnormalities that identifies people at risk for diabetes and cardiovascular disease. MetS is characterized by lipid disorders, and non-alcoholic fatty liver disease (NAFLD) and diabetic kidney disease (DKD) are thought to be the common hepatic and renal manifestations of MetS following abnormal lipid metabolism. This paper reviews the molecular mechanisms of lipid deposition in NAFLD and DKD, highlighting the commonalities and differences in lipid metabolic pathways in NAFLD and DKD. Hepatic and renal steatosis is the result of lipid acquisition exceeding lipid processing, i.e., fatty acid uptake and lipid regeneration exceed fatty acid oxidation and export. This process is directly regulated by the interactions of nuclear receptors, transporter proteins and transcription factors, whereas pathways such as oxidative stress, autophagy, cellular pyroptosis and gut flora are also key regulatory hubs for lipid metabolic homeostasis but act slightly differently in the liver and kidney. Such insights based on liver-kidney similarities and differences offer potential options for improved treatment.
C1 [Rong, Jin; Peng, Xiaoyu; Li, Ping; Zhao, Tingting] China Japan Friendship Hosp, Inst Clin Med Sci, State Key Lab Resp Hlth & Multimorbid, Beijing, Peoples R China.
   [Zhang, Zixuan; Zhong, Yifei] Shanghai Univ Tradit Chinese Med, Dept Nephrol A, Longhua Hosp, Shanghai, Peoples R China.
   [Rong, Jin] Shandong Second Med Univ, Coll Life Sci & Technol, Weifang, Shandong, Peoples R China.
   [Peng, Xiaoyu] Beijing Univ Chem Technol, Coll Life Sci & Technol, Beijing, Peoples R China.
C3 China-Japan Friendship Hospital; Shanghai University of Traditional
   Chinese Medicine; Shandong Second Medical University; Beijing University
   of Chemical Technology
RP Li, P; Zhao, TT (corresponding author), China Japan Friendship Hosp, Inst Clin Med Sci, State Key Lab Resp Hlth & Multimorbid, Beijing, Peoples R China.; Zhong, YF (corresponding author), Shanghai Univ Tradit Chinese Med, Dept Nephrol A, Longhua Hosp, Shanghai, Peoples R China.
EM rj18663519846@163.com; zhangzx5422@163.com; lp8675@163.com;
   ttfrfr@163.com; yifeilily@126.com
RI 小玉, 彭/AAJ-8122-2020
FU National Natural Science Foundation of China [82374224, U23A20504,
   82174296, 2022-82274451]; Training Programme for Research Physicians in
   Innovation and Transformation from shanghai hospital development center
   [SHDC2022CRD003]; National Key Research and Development Program of China
   [2022YFC2105601]; National High Level Hospital Clinical Research Funding
   [2023-NHLHCRF-DJMS-02]
FX This study was supported by National Natural Science Foundation of China
   (2022-82274451) , National Natural Science Foundation of China
   (82374224, U23A20504, 82174296) , Training Programme for Research
   Physicians in Innovation and Transformation from shanghai hospital
   development center (SHDC2022CRD003) , National Key Research and
   Development Program of China (2022YFC2105601) and National High Level
   Hospital Clinical Research Funding (2023-NHLHCRF-DJMS-02) .
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NR 196
TC 4
Z9 4
U1 9
U2 17
PU IVYSPRING INT PUBL
PI LAKE HAVEN
PA PO BOX 4546, LAKE HAVEN, NSW 2263, AUSTRALIA
SN 1449-2288
J9 INT J BIOL SCI
JI Int. J. Biol. Sci.
PY 2024
VL 20
IS 12
BP 4783
EP 4798
DI 10.7150/ijbs.100394
PG 16
WC Biochemistry & Molecular Biology; Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics
GA F9L6I
UT WOS:001312950500001
PM 39309427
OA gold
DA 2025-06-11
ER

PT J
AU Vlachojannis, C
   Zimmermann, BF
   Chrubasik-Hausmann, S
AF Vlachojannis, Christian
   Zimmermann, Benno F.
   Chrubasik-Hausmann, Sigrun
TI Quantification of Anthocyanins in Elderberry and Chokeberry Dietary
   Supplements
SO PHYTOTHERAPY RESEARCH
LA English
DT Article
DE Aronia; chokeberry fruit; elderberry fruit; metabolic syndrome;
   influenza; anthocanins
ID ARONIA-MELANOCARPA; OXIDATIVE STRESS; EXTRACT; POLYPHENOLS; METABOLISM;
   VIRUS; JUICE
AB Elderberry and chokeberry food supplements may be functional food' in patients with metabolic syndrome or influenza but, for this, adequate amounts of co-active ingredients must be consumed in the daily dose. This study aimed to quantify the anthocyanin content in three elderberry and six chokeberry products to assess their usefulness as functional food. Analyses were carried out using an established HPLC procedure. The minimum anthocyanin doses for the treatment of metabolic syndrome disorders were estimated as 110mg per day and 3.5g per day for influenza. Three products were inappropriate for clinical use. The lowest liquid supplies were achieved with a proprietary elderberry concentrate (11mL) and a proprietary chokeberry mother juice (100mL). Clinical studies are now required to prove the effectiveness and adapt the doses according to the clinical symptoms. Copyright (c) 2015 John Wiley & Sons, Ltd.
C1 [Vlachojannis, Christian; Chrubasik-Hausmann, Sigrun] Univ Freiburg, Inst Forens Med, D-79104 Freiburg, Germany.
   [Zimmermann, Benno F.] Univ Bonn, Dept Nutr & Food Sci, D-53117 Bonn, Germany.
   [Zimmermann, Benno F.] Inst Prof Dr Georg Kurz GmbH, D-50933 Cologne, Germany.
C3 University of Freiburg; University of Bonn
RP Chrubasik-Hausmann, S (corresponding author), Univ Freiburg, Inst Forens Med, Albertstr 9, D-79104 Freiburg, Germany.
EM sigrun.chrubasik@klinikum.uni-freiburg.de
RI Zimmermann, Benno/D-7147-2011
CR [Anonymous], EVID BASED COMPLEMEN
   Badescus L, 2012, EVID-BASED COMPL ALT, V2012, DOI DOI 10.1155/2012/848269
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NR 36
TC 30
Z9 34
U1 0
U2 53
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0951-418X
EI 1099-1573
J9 PHYTOTHER RES
JI Phytother. Res.
PD APR
PY 2015
VL 29
IS 4
BP 561
EP 565
DI 10.1002/ptr.5284
PG 5
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA CF5EY
UT WOS:000352580600010
PM 25597779
DA 2025-06-11
ER

PT J
AU Lin, YK
   Chen, YJ
   Chen, SA
AF Lin, Yung-Kuo
   Chen, Yi-Jen
   Chen, Shih-Ann
TI Potential atrial arrhythmogenicity of adipocytes: Implications for the
   genesis of atrial fibrillation
SO MEDICAL HYPOTHESES
LA English
DT Article
ID EPICARDIAL ADIPOSE-TISSUE; MONOCYTE CHEMOATTRACTANT PROTEIN-1;
   INDEPENDENT RISK-FACTOR; C-REACTIVE PROTEIN; METABOLIC SYNDROME;
   FOLLOW-UP; ECHOCARDIOGRAPHIC ABNORMALITIES; PROINFLAMMATORY CYTOKINES;
   CARDIOVASCULAR-DISEASE; CATHETER ABLATION
AB Atrial fibrillation is the most common sustained cardiac arrhythmia. Obesity and metabolic syndrome are independent risk factors for atrial fibrillation, and epicardial adipose tissues are highly associated with the genesis of atrial fibrillation, compared to visceral fat. Adipocytes can produce inflammatory cytokines and adipocytokines, which may enhance inflammation and oxidative stress in patients with obesity or metabolic syndrome. Moreover, it is possible that local interactions between epicardial adipose tissue and the adjacent myocardium can directly produce electrical or structural remodelings in the atrium. Taken together, we hypothesized that epicardial adipocytes contain distinctive arrhythmogenicity through increases in inflammatory cytokines, adipocytokines, and adipocyte-cardiomyocyte interactions to induce atrial fibrillation. Crown Copyright (C) 2010 Published by Elsevier Ltd. All rights reserved.
C1 [Chen, Yi-Jen] Taipei Med Univ Wan Fang Hosp, Div Cardiol, Dept Internal Med, Taipei 116, Taiwan.
   [Lin, Yung-Kuo] Far Eastern Mem Hosp, Ctr Cardiovasc, Taipei, Taiwan.
   [Lin, Yung-Kuo; Chen, Yi-Jen] Taipei Med Univ, Grad Inst Clin Med, Taipei, Taiwan.
   [Chen, Shih-Ann] Natl Yang Ming Univ, Sch Med, Taipei 112, Taiwan.
   [Chen, Shih-Ann] Vet Gen Hosp Taipei, Div Cardiol, Taipei, Taiwan.
   [Chen, Shih-Ann] Vet Gen Hosp Taipei, Cardiovasc Res Ctr, Taipei, Taiwan.
C3 Taipei Medical University; Far Eastern Memorial Hospital; Taipei Medical
   University; National Yang Ming Chiao Tung University
RP Chen, YJ (corresponding author), Taipei Med Univ Wan Fang Hosp, Div Cardiol, Dept Internal Med, 111 Hsin Lung Rd,Sec 3, Taipei 116, Taiwan.
EM a9900112@ms15.hinet.net
RI Lin, Chin-Yu/IRZ-9664-2023; Chen, Yun-Ti/IUM-1935-2023
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NR 70
TC 56
Z9 59
U1 0
U2 6
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0306-9877
EI 1532-2777
J9 MED HYPOTHESES
JI Med. Hypotheses
PD JUN
PY 2010
VL 74
IS 6
BP 1026
EP 1029
DI 10.1016/j.mehy.2010.01.004
PG 4
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 598UI
UT WOS:000277863900017
PM 20149554
DA 2025-06-11
ER

PT J
AU Abate, N
   Sallam, HS
   Rizzo, M
   Nikolic, D
   Obradovic, M
   Bjelogrlic, P
   Isenovic, ER
AF Abate, Nicola
   Sallam, Hanaa S.
   Rizzo, Manfredi
   Nikolic, Dragana
   Obradovic, Milan
   Bjelogrlic, Predrag
   Isenovic, Esma R.
TI Resistin: An Inflammatory Cytokine. Role in Cardiovascular Diseases,
   Diabetes and the Metabolic Syndrome
SO CURRENT PHARMACEUTICAL DESIGN
LA English
DT Article
DE Resistin; type 2 diabetes; cardiovascular diseases; metabolic syndrome
ID CORONARY-ARTERY-DISEASE; FATTY LIVER-DISEASE; INCREASES
   LIPID-ACCUMULATION; ACUTE MYOCARDIAL-INFARCTION; LIPOPROTEIN LDL
   SUBCLASSES; LOW-DENSITY LIPOPROTEINS; HUMAN ENDOTHELIAL-CELLS; SERUM
   RESISTIN; INSULIN-RESISTANCE; PLASMA RESISTIN
AB Resistin is an adipocyte-and monocyte-derived cytokine which has been implicated in the modulation of insulin action, energy, glucose and lipid homeostasis. Resistin has been associated with insulin resistance and many of its known complications. As a molecular link between metabolic signals, inflammation, and vascular dysfunction, resistin can be proposed as playing a significant role in the heightened inflammatory state induced by metabolic stress linked to excessive caloric intake, thus contributing to the risk for metabolic syndrome (MetS), type 2 diabetes (T2DM), and cardiovascular diseases (CVD). In this review, we highlighted the role of resistin, as an inflammatory cytokine, in the development of CVD, T2DM and the MetS.
C1 [Abate, Nicola; Sallam, Hanaa S.] Univ Texas Med Branch, Dept Internal Med, Div Endocrinol, Galveston, TX 77555 USA.
   [Sallam, Hanaa S.] Suez Canal Univ, Fac Med, Dept Physiol, Ismailia, Egypt.
   [Rizzo, Manfredi; Nikolic, Dragana] Univ Palermo, Biomed Dept Internal Med & Med Specialties, I-90133 Palermo, Italy.
   [Rizzo, Manfredi] Euromediterranean Inst Sci & Technol, Palermo, Italy.
   [Obradovic, Milan; Isenovic, Esma R.] Univ Belgrade, Inst Nucl Sci Vinca, Lab Radiobiol & Mol Genet, Belgrade 11000, Serbia.
   [Bjelogrlic, Predrag] Univ St Andrews, Sch Med, St Andrews, Fife, Scotland.
C3 University of Texas System; University of Texas Medical Branch
   Galveston; Egyptian Knowledge Bank (EKB); Suez Canal University;
   University of Palermo; University of Belgrade; University of St Andrews
RP Isenovic, ER (corresponding author), Univ Belgrade, Inst Vinca, Lab Radiobiol & Mol Genet, POB 522, Belgrade 11000, Serbia.
EM isenovic@yahoo.com
RI Sallam, Hanaa/ABD-7361-2020; RIZZO, MANFREDI/GZL-0551-2022; Obradovic,
   Milan/AGN-1229-2022; Isenovic, Esma/D-3017-2009
OI RIZZO, Manfredi/0000-0002-9549-8504; Isenovic, Esma/0000-0002-0012-2636;
   Nikolic, Dragana/0000-0001-9572-9651; Obradovic,
   Milan/0000-0002-4769-2652
FU Ministry of Science, Republic of Serbia [173033]
FX This work is supported by the grant No. 173033 (to E.R.I) from the
   Ministry of Science, Republic of Serbia.
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NR 166
TC 78
Z9 87
U1 0
U2 19
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1381-6128
EI 1873-4286
J9 CURR PHARM DESIGN
JI Curr. Pharm. Design
PY 2014
VL 20
IS 31
BP 4961
EP 4969
PG 9
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA AN7YJ
UT WOS:000340816600004
PM 24320036
DA 2025-06-11
ER

PT J
AU Han, L
   Bittner, S
   Dong, DC
   Cortez, Y
   Dulay, H
   Arshad, S
   Shen, WJ
   Kraemer, FB
   Azhar, S
AF Han, Lu
   Bittner, Stefanie
   Dong, Dachuan
   Cortez, Yuan
   Dulay, Hunter
   Arshad, Sara
   Shen, Wen-Jun
   Kraemer, Fredric B.
   Azhar, Salman
TI Creosote bush-derived NDGA attenuates molecular and pathological changes
   in a novel mouse model of non-alcoholic steatohepatitis (NASH)
SO MOLECULAR AND CELLULAR ENDOCRINOLOGY
LA English
DT Article
DE Hepatic steatosis; NAFLD; Nordihydroguaiaretic acid; Hepatic fibrosis;
   Insulin resistance; Metabolic syndrome
ID FATTY LIVER-DISEASE; HEPATIC PROGENITOR CELLS; METABOLIC SYNDROME;
   NORDIHYDROGUAIARETIC ACID; LIFE-SPAN; CARDIOVASCULAR-DISEASE;
   DIABETES-MELLITUS; RESPONSE ELEMENT; PPAR-ALPHA; PATHOGENESIS
AB Creosote bush (Larrea tridentata)-derived nordihydroguaiaretic acid (NDGA) was shown to have profound effects on the core components of metabolic syndrome. This study investigated the in vivo potential of NDGA for prevention or attenuation of the pathophysiologic abnormalities of NASH. A novel dietary NASH model with feeding C57BL/6J mice with a high trans-fat, high cholesterol and high fructose (HTF) diet, was used. The HTF diet fed mice exhibited obesity, insulin resistance, hepatic steatosis, fibrosis, inflammation, ER stress, oxidative stress, and liver injury. NDGA attenuated these metabolic abnormalities as well as hepatic steatosis and fibrosis together with attenuated expression of genes encoding fibrosis, progenitor and macrophage markers with no effect on the levels of mRNAs for lipogenic enzymes. NDGA increased expression of fatty acid oxidation genes. In conclusion, NDGA exerts anti-NASH/anti-fibrotic actions and raises the therapeutic potential of NDGA for treatment of NASH patients with fibrosis and other associated complications.
C1 [Han, Lu; Bittner, Stefanie; Dong, Dachuan; Cortez, Yuan; Dulay, Hunter; Arshad, Sara; Shen, Wen-Jun; Kraemer, Fredric B.; Azhar, Salman] VA Palo Alto Hlth Care Syst, Geriatr Res Educ & Clin Ctr, Palo Alto, CA 94304 USA.
   [Han, Lu; Dong, Dachuan; Arshad, Sara; Shen, Wen-Jun; Kraemer, Fredric B.; Azhar, Salman] Stanford Univ, Div Endocrinol Gerontol & Metab, Stanford, CA 94305 USA.
   [Kraemer, Fredric B.; Azhar, Salman] Stanford Diabet Res Ctr, Stanford, CA USA.
C3 US Department of Veterans Affairs; Veterans Health Administration (VHA);
   VA Palo Alto Health Care System; Geriatric Research Education & Clinical
   Center; Stanford University
RP Shen, WJ (corresponding author), Stanford Univ, Sch Med, Div Endocrinol, S025, Stanford, CA 94305 USA.; Azhar, S (corresponding author), VA Palo Alto Hlth Care Syst, GRECC 182B,3801 Miranda Ave, Palo Alto, CA 94304 USA.
EM wenjun@stanford.edu; salman.azhar@va.gov
RI Kraemer, Fredric/AAC-3633-2019; Shen, Wen-Jun/ACG-0761-2022
OI Dong, Dachuan/0000-0002-5443-5304; Kraemer, Fredric/0000-0003-2468-7807;
   Dulay, Hunter/0000-0001-6928-6754; Shen, Wen-Jun/0000-0001-5150-1698
FU National Institutes of Health [1R01HL92473, P30DK116074]; United States
   Department of Veterans Affairs, Biomedical Laboratory Research
   Development Program [I01BX001923, I01BX000398, IK6B004200]
FX This work was supported by the National Institutes of Health grants
   1R01HL92473 (SA) and P30DK116074 (FBK), and by Merit Review Awards
   #I01BX001923 (SA) and #I01BX000398 (FBK), and Senior Research Career
   Scientist Award #IK6B004200 (SA) from the United States Department of
   Veterans Affairs, Biomedical Laboratory Research Development Program.
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NR 93
TC 8
Z9 8
U1 2
U2 20
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0303-7207
J9 MOL CELL ENDOCRINOL
JI Mol. Cell. Endocrinol.
PD DEC 1
PY 2019
VL 498
AR 110538
DI 10.1016/j.mce.2019.110538
PG 11
WC Cell Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Endocrinology & Metabolism
GA JF2TM
UT WOS:000491238400009
PM 31415794
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Bose, S
   Dey, N
AF Bose, Saheli
   Dey, Nirmalya
TI MicroRNAs: Tiny biomolecules with soaring impact in regulation of
   metabolic syndrome
SO GENE REPORTS
LA English
DT Article
DE Metabolic syndrome; MicroRNA; Insulin; Obesity; Diabetes; Therapeutics
ID INSULIN; OBESITY
AB Dysregulated physiological pathways are a hallmark of metabolic syndromes and often act as cancer risk factors. MicroRNAs (miRNAs) have become important regulators of many biological processes, including growth, development and metabolism. MicroRNAs often play a dual role in metabolic syndromes and cancer development through the modulation of pathways that affect cell proliferation, energy balance, and cellular stress responses. Obesity, insulin resistance, type 2 Diabetes, cardiovascular diseases, hypertension, dyslipidemia do always remain 'list toppers' since the inception of the concept of 'metabolic syndrome'. Aberrantly expressed miRNAs exhibit to play a pivotal role in disturbed metabolic pathways, chronic inflammation, and oxidative stress rendering people predisposed to these metabolic disorders. MicroRNAs can diagnose and predict outcomes in various pathophysiological instances. Hence, miRNA profiles can act as biomarkers for early illness diagnosis, disease progression, and treatment response. The complex crosstalk between different metabolic pathways may be managed by using miRNAs as therapeutic targets or tools for precision medicine. The current review focuses on elaborating the complex functions played by miRNAs in bridging the gap between the unexplored areas of metabolic syndromes, keeping cancer off this discussion.
C1 [Bose, Saheli; Dey, Nirmalya] Amity Univ, Amity Inst Biotechnol, Room 504,Acad Bldg Plot 36,37 & 38,Major Arterial, Kolkata 700135, West Bengal, India.
RP Dey, N (corresponding author), Amity Univ, Amity Inst Biotechnol, Room 504,Acad Bldg Plot 36,37 & 38,Major Arterial, Kolkata 700135, West Bengal, India.
EM saheli.bose@s.amity.edu; ndey@kol.amity.edu
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NR 57
TC 0
Z9 0
U1 2
U2 4
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
EI 2452-0144
J9 GENE REP
JI Gene Rep.
PD DEC
PY 2024
VL 37
AR 102084
DI 10.1016/j.genrep.2024.102084
PG 9
WC Genetics & Heredity
WE Emerging Sources Citation Index (ESCI)
SC Genetics & Heredity
GA M3Z3Z
UT WOS:001356957800001
DA 2025-06-11
ER

PT J
AU Hajer, GR
   van der Graaf, Y
   Olijhoek, JK
   Edlinger, M
   Visseren, FLJ
AF Hajer, Gideon R.
   van der Graaf, Yolanda
   Olijhoek, Jobien K.
   Edlinger, Michael
   Visseren, Frank L. J.
TI Low plasma levels of adiponectin are associated with low risk for future
   cardiovascular events in patients with clinical evident vascular disease
SO AMERICAN HEART JOURNAL
LA English
DT Article
ID CORONARY-HEART-DISEASE; INSULIN-RESISTANCE; METABOLIC SYNDROME; SERUM
   ADIPONECTIN; MORTALITY; PROTEIN; DEPRESSION; GLUCOSE; PREDICT
AB Background Adiponectin is considered to have anti-inflammatory, insulin-sensitizing, and anti atherosclerotic properties. In the present prospective study, the relationship between metabolic syndrome (Adult Treatment Panel III) and adiponectin plasma levels and the relationship between plasma adiponectin levels and future cardiovascular events were investigated.
   Methods A case-cohort study of 431 patients with clinical evident vascular disease from the Second Manifestations of ARTerial Disease study. The relationship between adiponectin plasma levels and new vascular events was investigated with Cox regression, adjusted for potential confounders and effect modifiers (age, sex, renal function [modification of diet in renal disease], body mass index, high sensitive C-reactive protein, use of angiotensin converting enzyme-inhibition and/or All antagonists, and presence of metabolic syndrome or impaired renal function).
   Results Plasma adiponectin levels were lower in patients with metabolic syndrome as compared with patients without (7.9 +/- 0.3 vs 5.2 +/- 0.3 mu g/mL) and decreased with the number of components. During a mean follow-up of 2.3 years, 216 patients had a new cardiovascular event. Lower adiponectin plasma levels were associated with a lower risk for future cardiovascular events (hazard ratio 0.50, 95% confidence interval 0.25-0.99). This relationship was not influenced by renal function, body mass index, and renin-angiotensin system-blocking agents or modified by metabolic syndrome and impaired renal function.
   Conclusion In patients with clinical evident vascular disease, lower adiponectin levels were associated with a lower cardiovascular risk. Therefore, it may be hypothesized that the potential antiatherosclerotic properties of adiponectin do not apply for patients with already established vascular disease.
C1 Julius Ctr Hlth Sci & Primary Care, UMC Utrecht, NL-3584 CX Utrecht, Netherlands.
   Dept Vasc Med, UMC Utrecht, Utrecht, Netherlands.
RP van der Graaf, Y (corresponding author), Julius Ctr Hlth Sci & Primary Care, UMC Utrecht, Heidelberglaan 100, NL-3584 CX Utrecht, Netherlands.
EM y.vandergraaf@umcutrecht.nl
RI Visseren, Frank/I-4855-2013
OI Edlinger, Michael/0000-0001-8801-3268; Visseren,
   Frank/0000-0003-3951-5223
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NR 33
TC 23
Z9 28
U1 0
U2 1
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0002-8703
EI 1097-5330
J9 AM HEART J
JI Am. Heart J.
PD OCT
PY 2007
VL 154
IS 4
DI 10.1016/j.ahj.2007.07.013
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 217KR
UT WOS:000249947300031
DA 2025-06-11
ER

PT J
AU Bruins, J
   Pijnenborg, GHM
   van den Heuvel, ER
   Visser, E
   Corpeleijn, E
   Bartels-Velthuis, AA
   Bruggeman, R
   Jörg, F
AF Bruins, Jojanneke
   Pijnenborg, Gerdina H. M.
   van den Heuvel, Edwin R.
   Visser, Ellen
   Corpeleijn, Eva
   Bartels-Velthuis, Agna A.
   Bruggeman, Richard
   Jorg, Frederike
TI Persistent Low Rates of Treatment of Metabolic Risk Factors in People
   With Psychotic Disorders: A PHAMOUS Study
SO JOURNAL OF CLINICAL PSYCHIATRY
LA English
DT Article
ID SCHIZOPHRENIA SPECTRUM DISORDERS; SEVERE MENTAL-ILLNESS; CARDIOVASCULAR
   RISK; PHYSICAL HEALTH; TASK-FORCE; CARDIOMETABOLIC RISK; PRACTICE
   GUIDELINES; CLINICAL-PRACTICE; MANAGEMENT; CARE
AB Objective: People with psychotic disorders have an increased metabolic risk and a shortened life expectancy compared to the general population. Two large studies showed that metabolic disorders were untreated in a majority of the patients. Since then, guidelines have urged monitoring of metabolic health. This study examined the course of metabolic disorders over time in people with psychotic disorders and investigated current treatment rates.
   Methods: A total of 1,259 patients with psychotic disorders, as defined by the DSM-IV, from 4 Dutch mental health institutions participated in 3 yearly assessments of the Pharmacotherapy Monitoring and Outcome Survey (PHAMOUS) between 2006 and 2014. Patients' metabolic parameters were measured, and the use of pharmacologic treatment for hypertension (systolic blood pressure >= 140 mm Hg and/or diastolic blood pressure >= 90 mm Hg), dyslipidemia (5% <= Systematic COronary Risk Evaluation [SCORE] risk < 10% and low-density lipoprotein [LDL] cholesterol level >= 2.5 mmol/L or SCORE risk >= 10% and LDL cholesterol level >= 1.8 mmol/L and/or triglycerides >= 2.3 mmol/L), and hyperglycemia (hemoglobin A(1c) concentration > 7% and/or fasting glucose concentration >= 7.2 mmol/L) was recorded.
   Results: Prevalence of the metabolic syndrome, as defined by the National Cholesterol Education Program criteria, was > 50% at each assessment. On the basis of the European Society of Cardiology guidelines, pharmacotherapy for metabolic disorders was recommended for 52%-59% of the patients at each assessment. Treatment rates with antihypertensive (from 31% to 38%, P < .001) pharmacotherapy increased throughout the assessments. However, half of the patients were not treated for their metabolic risk factors while being monitored for 3 years or longer. Older patients were more likely to receive treatment, and patients who received treatment had lower blood pressure and lower cholesterol and triglyceride concentrations than patients not receiving the recommended treatment.
   Conclusions: Metabolic risk factors are still seriously undertreated in people with psychotic disorders. Better adherence to and better implementation of guidelines about monitoring and treating metabolic disorders in psychiatry are crucial. (C) Copyright 2017 Physicians Postgraduate Press, Inc.
C1 [Bruins, Jojanneke; Visser, Ellen; Bartels-Velthuis, Agna A.; Bruggeman, Richard; Jorg, Frederike] Univ Groningen, Univ Med Ctr Groningen, Univ Ctr Psychiat, Rob Giel Res Ctr, Hanzepl 1,CC72, NL-9713 GZ Groningen, Netherlands.
   [Bruins, Jojanneke; Bartels-Velthuis, Agna A.] Lentis Mental Hlth Org, Groningen, Netherlands.
   [Pijnenborg, Gerdina H. M.] Univ Groningen, Dept Psychol, Groningen, Netherlands.
   [Pijnenborg, Gerdina H. M.] GGZ Drenthe, Dept Psychot Disorders, Assen, Drenthe, Netherlands.
   [van den Heuvel, Edwin R.; Corpeleijn, Eva] Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, Groningen, Netherlands.
   [van den Heuvel, Edwin R.] Eindhoven Univ Technol, Dept Math & Comp Sci, Eindhoven, Netherlands.
   [Jorg, Frederike] Friesland Mental Hlth Serv, Res Dept, Leeuwarden, Friesland, Netherlands.
C3 University of Groningen; University of Groningen; University of
   Groningen; Eindhoven University of Technology
RP Bruins, J (corresponding author), Univ Groningen, Univ Med Ctr Groningen, Univ Ctr Psychiat, Rob Giel Res Ctr, Hanzepl 1,CC72, NL-9713 GZ Groningen, Netherlands.
EM j.bruins@lentis.nl
RI Jörg, Frederike/B-1325-2014; Pijnenborg, Gerdina/A-7437-2011; Van den
   Heuvel, Edwin/C-5166-2013
OI Visser, Ellen/0000-0002-6370-5484; Corpeleijn, Eva/0000-0002-2974-3305;
   Bruins, Jojanneke/0000-0002-5345-0748
FU Rob Giel Research Center at the University Center for Psychiatry of the
   University Medical Center Groningen; Friesland Mental Health Services;
   GGZ Drenthe; Lentis Mental Health Organization; University Medical
   Center Groningen
FX This work was supported by the Rob Giel Research Center at the
   University Center for Psychiatry of the University Medical Center
   Groningen, Friesland Mental Health Services, GGZ Drenthe and Lentis
   Mental Health Organization. The study was funded by the mental health
   institutions participating in PHAMOUS screenings: University Medical
   Center Groningen, Lentis Mental Health Organization, GGZ Drenthe,
   Friesland Mental Health Services. This research received no specific
   grant from any funding agency in the public, commercial, or
   not-for-profit sectors.
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NR 60
TC 20
Z9 20
U1 0
U2 5
PU PHYSICIANS POSTGRADUATE PRESS
PI MEMPHIS
PA P O BOX 752870, MEMPHIS, TN 38175-2870 USA
SN 0160-6689
EI 1555-2101
J9 J CLIN PSYCHIAT
JI J. Clin. Psychiatry
PD SEP-OCT
PY 2017
VL 78
IS 8
BP 1117
EP +
DI 10.4088/JCP.16m10831
PG 11
WC Psychology, Clinical; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA FK7VZ
UT WOS:000413716700029
PM 28406264
OA Green Published
DA 2025-06-11
ER

PT J
AU Jadhav, S
   Ferrell, W
   Greer, IA
   Petrie, JR
   Cobbe, SM
   Sattar, N
AF Jadhav, Sachin
   Ferrell, William
   Greer, Ian A.
   Petrie, John R.
   Cobbe, Stuart M.
   Sattar, Naveed
TI Effects of metformin on microvascular function and exercise tolerance in
   women with angina and normal coronary arteries - A randomized,
   double-blind, placebo-controlled study
SO JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
LA English
DT Article
ID INSULIN-RESISTANCE SYNDROME; TYPE-2 DIABETES-MELLITUS; NITRIC-OXIDE
   SYNTHESIS; SYNDROME-X; ENDOTHELIAL DYSFUNCTION; HEART-DISEASE;
   POSTMENOPAUSAL WOMEN; CARDIOVASCULAR RISK; CONTROLLED-TRIAL; KINASE
AB OBJECTIVES This study sought to determine whether metformin improves vascular function or myocardial ischemia in nondiabetic subjects.
   BACKGROUND Metformin prevents diabetes and may reduce coronary events in patients with diabetes, but effects on microvascular function and angina are not clear.
   METHODS We conducted an 8-week double-blind, randomized, placebo-controlled study of metformin 500 mg twice a day in 33 nondiabetic women with a prior history of normal coronary angiography but two consecutive positive (ST-segment depression >= 1 mm) exercise tolerance tests. All parameters were measured at baseline and at 8 weeks, together with an in vivo assessment of forearm (skin) microvascular function using laser Doppler imaging combined with iontophoresis.
   RESULTS In comparison with placebo (n = 17), metformin recipients (n = 16) showed significant reductions in weight and in homeostatic model assessment for insulin resistance (p < 0.05, intention to treat). Endothelium-dependent microvascular responses improved significantly with metformin (2-way repeated analysis of variance, p = 0.0003), but responses with placebo were unchanged (p = 0.50). A comparison of change in acetylcholine responses between metformin and placebo recipients was significant, whether analyzed by a 2-way analysis of variance (p < 0.0001) or change in area under curves (mean change +392 perfusion units, 95% confidence interval [Cl] 20 to 764). Endothelium-independent responses were not altered. Maximal ST-segment depression (-0.84 mm, 95% Cl -1.49 to -0.20, p = 0.013), Duke score (6.1 U, 95% Cl 1.8 to 10.5, p = 0.008), and chest pain incidence (-0.11 episodes/day, 95% CI -0.22 to 0.00, p = 0.056) improved in metformin relative to placebo recipients.
   CONCLUSIONS Metformin may improve vascular function and decrease myocardial ischemia in nondiabetic women with chest pain and angiographically normal coronary arteries. Larger controlled trials of longer duration are warranted.
C1 Univ Glasgow, BHF Glasgow Cardiovasc Res Ctr, Glasgow Royal Infirm, Glasgow G31 2ER, Lanark, Scotland.
   Univ Glasgow, Div Cardiovasc & Med Sci, Glasgow Royal Infirm, Glasgow, Lanark, Scotland.
   Univ Glasgow, Div Dev Med, Glasgow Royal Infirm, Glasgow, Lanark, Scotland.
   Ninewells Hosp & Med Sch, Div Med & Therapeut, Dundee, Scotland.
C3 University of Glasgow; University of Glasgow; University of Glasgow;
   University of Dundee
RP Sattar, N (corresponding author), Univ Glasgow, BHF Glasgow Cardiovasc Res Ctr, Glasgow Royal Infirm, Glasgow G31 2ER, Lanark, Scotland.
EM nsattar@clinmed.gla.ac.uk
RI Petrie, John/ADA-1479-2022; Sattar, Naveed/AFN-0504-2022
OI Petrie, John/0000-0002-4894-9819
CR Bellamy MF, 1998, CARDIOVASC RES, V40, P410, DOI 10.1016/S0008-6363(98)00184-9
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NR 36
TC 115
Z9 125
U1 0
U2 8
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0735-1097
J9 J AM COLL CARDIOL
JI J. Am. Coll. Cardiol.
PD SEP 5
PY 2006
VL 48
IS 5
BP 956
EP 963
DI 10.1016/j.jacc.2006.04.088
PG 8
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 081NO
UT WOS:000240324500008
PM 16949486
DA 2025-06-11
ER

PT J
AU Demir, H
   Kahraman, G
   Isgoren, S
   Tan, YZ
   Kilic, T
   Berk, F
AF Demir, Hakan
   Kahraman, Goksel
   Isgoren, Serkan
   Tan, Yusuf Ziya
   Kilic, Teornan
   Berk, Fatma
TI Evaluation of post-stress left ventricular dysfunction and its
   relationship with perfusion abnormalities using gated SPECT in patients
   with cardiac syndrome X
SO NUCLEAR MEDICINE COMMUNICATIONS
LA English
DT Article
DE cardiac syndrome X; gated SPECT; left ventricular dysfunction;
   (99m)Tc-MIBI
ID EMISSION COMPUTED-TOMOGRAPHY; CORONARY-ARTERY-DISEASE; REGIONAL
   WALL-MOTION; EJECTION FRACTION; ANGINA-PECTORIS; MYOCARDIAL-INFARCTION;
   VASODILATOR STRESS; FUNCTIONAL RESERVE; EXERCISE; ECHOCARDIOGRAPHY
AB Objective Cardiac syndrome X defines patients with typical angina, a positive exercise ECG stress test and angiographically documented normal coronary arteries. In previous studies, post-stress prolonged left ventricular dysfunction (PLVD) using gated SPECT (G-SPECT) had been well correlated with myocardial perfusion abnormalities and degree of stenotic vessels in CAG in patients with coronary artery disease. However, evaluation of left ventricular myocardial perfusion, wall motion and left ventricular ejection fraction (LVEF) in patients with cardiac syndrome X, using G-SPECT had not been studied yet. Thus, the aim of this study was to analyse PLVD using (99m)Tc-MIBI GSPECT in patients with cardiac syndrome X.
   Methods Of the patients in whom G-SPECT was performed in our institution between 2004 and 2006, 17 patients with anginal chest pain, positive exercise ECG stress test and normal coronary angiograms were retrospectively included to the study (group I. Fifteen patients with normal myocardial perfusion and another 15 patients with ischaemia on G-SPECT were selected as control groups (groups II and III). (99m)Tc-MIBI G-SPECT was performed for all patients according to 2 day (stress-rest) protocol. Stress and rest LVEF were derived automatically (SLVEF and RLVEF). Difference LVEF (DLVEF) (stress-rest) was calculated. Semiquantitative analyses were made both for myocardial perfusion and wall motion (WM), using a 20-segment model and a 5-point scoring system. DLVEF, perfusion and WM scores of all groups were compared among three groups and relationship between DLVEF, perfusion and WM scores were evaluated.
   Results Abnormal perfusion were detected in eight (47.1%) of patients, while the remaining nine (52.9%) had normal myocardial perfusion, in group I. Six of 17 (35.3%) patients in group I had post-stress WM abnormalities. Mean of DLVEF values were -3.1 +/- 3.0%, 4.4 +/- 2.0% and -6.0 +/- 5.1% in groups I, II and III, respectively (P<0.05 for group II vs. group I and group III; P>0.05 for group I vs. group III). LVEF response impairment (<= 5% increase from rest to post-stress images) was found in 17 (100%), seven (46.6%), 14 (93.3%) of patients in groups I, II and III, respectively.
   Conclusion Abnormal myocardial perfusion, concordant transient segmental WM abnormalities and LVEF response impairment are not uncommon in patients with cardiac syndrome X of this cohort of the study population. Therefore, post-stress prolonged stunning may be attributed to these findings in some of cardiac syndrome X patients as in true ischaemic patients. However, further studies with larger number of subjects and long-term follow-up are necessary to support these findings.
C1 [Demir, Hakan; Isgoren, Serkan; Tan, Yusuf Ziya; Berk, Fatma] Kocaeli Univ, Sch Med, Dept Nucl Med, TR-41380 Kocaeli, Turkey.
   [Kahraman, Goksel; Kilic, Teornan] Kocaeli Univ, Sch Med, Dept Cardiol, TR-41380 Kocaeli, Turkey.
C3 Kocaeli University; Kocaeli University
RP Demir, H (corresponding author), Kocaeli Univ, Sch Med, Dept Nucl Med, TR-41380 Kocaeli, Turkey.
EM hakandemir99@yahoo.com
RI TAN, YUSUF/JZT-7359-2024; Kahraman, Goksel/J-2267-2018; isgoren,
   Serkan/A-5733-2018
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NR 45
TC 10
Z9 12
U1 0
U2 6
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0143-3636
J9 NUCL MED COMMUN
JI Nucl. Med. Commun.
PD MAR
PY 2008
VL 29
IS 3
BP 208
EP 214
DI 10.1097/MNM.0b013e3282f52c49
PG 7
WC Radiology, Nuclear Medicine & Medical Imaging
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Radiology, Nuclear Medicine & Medical Imaging
GA 265BD
UT WOS:000253333200003
DA 2025-06-11
ER

PT J
AU Manusov, EG
   Diego, VP
   Sheikh, K
   Laston, S
   Blangero, J
   Williams-Blangero, S
AF Manusov, Eron Grant
   Diego, Vincent P.
   Sheikh, Khalid
   Laston, Sandra
   Blangero, John
   Williams-Blangero, Sarah
TI Non-alcoholic Fatty Liver Disease and Depression: Evidence for Genotype
   x Environment Interaction in Mexican Americans
SO FRONTIERS IN PSYCHIATRY
LA English
DT Article
DE G x E; liver disease; Mexican Americans; depression; heritability
ID TRANSIENT ELASTOGRAPHY FIBROSCAN; METABOLIC SYNDROME; SOCIAL
   DETERMINANTS; SELF-CARE; INFLAMMATION; STEATOSIS; RISK; INDIVIDUALS;
   INVENTORY; CIRRHOSIS
AB This study examines the impact of G x E interaction effects on non-alcoholic fatty liver disease (NAFLD) among Mexican Americans in the Rio Grande Valley (RGV) of South Texas. We examined potential G x E interaction using variance components models and likelihood-based statistical inference in the phenotypic expression of NAFLD, including hepatic steatosis and hepatic fibrosis (identified using vibration controlled transient elastography and controlled attenuation parameter measured by the FibroScan Device). We screened for depression using the Beck Depression Inventory-II (BDI-II). We identified significant G x E interactions for hepatic fibrosis x BDI-II. These findings provide evidence that genetic factors interact with depression to influence the expression of hepatic fibrosis.
C1 [Manusov, Eron Grant; Diego, Vincent P.; Laston, Sandra; Blangero, John; Williams-Blangero, Sarah] Univ Texas Rio Grande Valley, Dept Human Genet, Brownsville, TX 78520 USA.
   [Manusov, Eron Grant; Diego, Vincent P.; Laston, Sandra; Blangero, John; Williams-Blangero, Sarah] Univ Texas Rio Grande Valley, South Texas Diabet & Obes Inst, Sch Med, Brownsville, TX 78520 USA.
   [Sheikh, Khalid] Univ Texas Rio Grande Valley, Sch Med, Edinburg, TX USA.
C3 University of Texas System; University of Texas Rio Grande Valley;
   University of Texas System; University of Texas Rio Grande Valley;
   University of Texas System; University of Texas Rio Grande Valley
RP Manusov, EG (corresponding author), Univ Texas Rio Grande Valley, Dept Human Genet, Brownsville, TX 78520 USA.; Manusov, EG (corresponding author), Univ Texas Rio Grande Valley, South Texas Diabet & Obes Inst, Sch Med, Brownsville, TX 78520 USA.
EM eron.manusov@utrgv.edu
RI Manusov, Eron/AAK-4759-2021; Blangero, John/ABA-7175-2021
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NR 62
TC 8
Z9 8
U1 0
U2 2
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-0640
J9 FRONT PSYCHIATRY
JI Front. Psychiatry
PD JUL 1
PY 2022
VL 13
AR 936052
DI 10.3389/fpsyt.2022.936052
PG 7
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 3A8GH
UT WOS:000827492100001
PM 35845438
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Isogawa, A
   Yamakado, M
   Yano, M
   Shiba, T
AF Isogawa, Akihiro
   Yamakado, Minoru
   Yano, Masao
   Shiba, Teruo
TI Serum superoxide dismutase activity correlates with the components of
   metabolic syndrome or carotid artery intima-media thickness
SO DIABETES RESEARCH AND CLINICAL PRACTICE
LA English
DT Article
DE Superoxide dismutase; Metabolic syndrome; Carotid intima-media thickness
ID LOW-DENSITY-LIPOPROTEIN; OXIDATIVE STRESS; ADHESION MOLECULE-1;
   SIGNALING PATHWAYS; ACTIVATION; EXPRESSION; CELLS; HYPERTENSION;
   ISOFORMS
AB The activities of the enzymes to eliminate reactive oxygen species prevent the progression of atherosclerosis. We conducted a cross-sectional study among 3234 people that underwent total health check-up service, and studied the relationship between the serum superoxide dismutase (SOD) activity and risk factors of atherosclerosis or carotid artery intima-media thickness (IMT). Serum SOD activity negatively correlated with body mass index (BMI), systolic and diastolic blood pressure, serum triglyceride (TG) concentration and serum glucose concentration. Low serum SOD activity positively correlated with the carotid IMT thickening. But on the other hand, existence of carotid artery plaque positively correlated with serum SOD activity especially among men. Serum SOD activity negatively correlated with the components of metabolic syndrome and low serum SOD activity seems to be an independent risk of the thickening of carotid IMT. On the other hand, serum SOD activity level seems to elevate limitedly but reactively to the status of increased oxidative stress, such as carotid plaque formation. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
RP Isogawa, A (corresponding author), 1 Kanda Izumi Cho,Chiyoda Ku, Tokyo, Japan.
EM isogawa-tky@umin.ac.jp
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NR 27
TC 29
Z9 34
U1 0
U2 1
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0168-8227
EI 1872-8227
J9 DIABETES RES CLIN PR
JI Diabetes Res. Clin. Pract.
PD DEC
PY 2009
VL 86
IS 3
BP 213
EP 218
DI 10.1016/j.diabres.2009.09.007
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 529MQ
UT WOS:000272521800009
PM 19819039
DA 2025-06-11
ER

PT J
AU Pingali, U
   Vuppalanchi, B
   Nutalapati, C
   Gundagani, S
AF Pingali, Usharani
   Vuppalanchi, Bhavani
   Nutalapati, Chandrasekhar
   Gundagani, Srinivas
TI Aqueous Azadirachta indica (Neem) Extract Attenuates Insulin
   Resistance to Improve Glycemic Control and Endothelial Function in
   Subjects with Metabolic Syndrome
SO JOURNAL OF MEDICINAL FOOD
LA English
DT Article
DE Azadirachta indica; endothelial dysfunction; hyperglycemia; insulin
   resistance; metabolic syndrome; neem; systemic inflammation
ID INFLAMMATION; VASODILATION; DYSFUNCTION
AB Neem (Azadirachta indica) exhibits multiple therapeutic benefits in preclinical studies, but clinical studies are lacking. This clinical study investigated the efficacy and safety of an aqueous A. indica leaf and twig extract (NEEM) on metabolic parameters in subjects with metabolic syndrome (MetS). Subjects were randomized to receive (1) placebo or (2) 125 mg, (3) 250 mg, or (4) 500 mg of NEEM twice daily (n = 20/group) for 12 weeks. Fasting blood sugar (FBS) and insulin, postprandial blood sugar (PPBS), insulin resistance (IR), hemoglobin A1c (HbA1c), endothelial function, circulating markers of inflammation and oxidative stress, lipid profiles, and platelet aggregation were measured at weeks 0, 4, 8, and 12. NEEM supplementation dose dependently improved the trajectories for FBS, PPBS, IR, and HbA1c over time, as well as endothelial function and most markers of inflammation and oxidative stress. Therefore, NEEM may be considered a promising therapeutic to attenuate the hyperglycemia and associated cardiometabolic derangements in people with MetS. Clinical trial registration no.: CTRI/2019/03/018034 [registered on: March 12, 2019].</p>
C1 [Pingali, Usharani; Vuppalanchi, Bhavani; Nutalapati, Chandrasekhar; Gundagani, Srinivas] Nizams Inst Med Sci, Dept Clin Pharmacol & Therapeut, Hyderabad 500082, India.
C3 Nizam's Institute of Medical Sciences
RP Pingali, U (corresponding author), Nizams Inst Med Sci, Dept Clin Pharmacol & Therapeut, Hyderabad 500082, India.
EM ushapingali@yahoo.com
OI , Vuppalanchi Bhavani/0009-0006-4138-062X; Nutalapati,
   Chandrasekhar/0000-0002-0529-2706
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NR 35
TC 7
Z9 7
U1 0
U2 2
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1096-620X
EI 1557-7600
J9 J MED FOOD
JI J. Med. Food
PD NOV 1
PY 2021
VL 24
IS 11
BP 1135
EP 1144
DI 10.1089/jmf.2020.4838
EA SEP 2021
PG 10
WC Chemistry, Medicinal; Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Food Science & Technology; Nutrition &
   Dietetics
GA WZ5KV
UT WOS:000717386100001
PM 34582720
DA 2025-06-11
ER

PT J
AU Tain, YL
   Hsu, CN
AF Tain, You-Lin
   Hsu, Chien-Ning
TI Developmental Programming of the Metabolic Syndrome: Can We Reprogram
   with Resveratrol?
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE developmental origins of health and disease (DOHaD); hypertension;
   metabolic syndrome; nitric oxide; nutrient-sensing signal; obesity;
   oxidative stress; renin-angiotensin system; resveratrol
ID HIGH-FAT DIET; RENIN-ANGIOTENSIN SYSTEM; LOW-PROTEIN DIET; ASYMMETRIC
   DIMETHYLARGININE; PRENATAL HYPOXIA; OXIDATIVE STRESS; NITRIC-OXIDE;
   PREVENTS; HYPERTENSION; ORIGINS
AB Metabolic syndrome (MetS) is a mounting epidemic worldwide. MetS can start in early life, in a microenvironment that is now known as the developmental origins of health and disease (DOHaD). The concept of DOHaD also offers opportunities for reprogramming strategies that aim to reverse programming processes in early life. Resveratrol, a polyphenolic compound has a wide spectrum of beneficial effects on human health. In this review, we first summarize the epidemiological and experimental evidence supporting the developmental programming of MetS. This review also presents an overview of the evidence linking different molecular targets of resveratrol to developmental programming of MetS-related disorders. This will be followed by studies documenting resveratrol as a reprogramming agent to protect against MetS-related disorders. Further clinical studies are required in order to bridge the gap between animal models and clinical trials in order to establish the effective dose and therapeutic duration for resveratrol as a reprogramming therapy on MetS disorders from developmental origins.
C1 [Tain, You-Lin] Kaohsiung Chang Gung Mem Hosp, Dept Pediat, Kaohsiung 833, Taiwan.
   [Tain, You-Lin] Chang Gung Univ, Coll Med, Kaohsiung 833, Taiwan.
   [Tain, You-Lin] Kaohsiung Chang Gung Mem Hosp, Inst Translat Res Biomed, Kaohsiung 833, Taiwan.
   [Hsu, Chien-Ning] Kaohsiung Chang Gung Mem Hosp, Dept Pharm, Kaohsiung 833, Taiwan.
C3 Chang Gung Memorial Hospital; Chang Gung University; Chang Gung Memorial
   Hospital; Chang Gung Memorial Hospital
RP Hsu, CN (corresponding author), Kaohsiung Chang Gung Mem Hosp, Dept Pharm, Kaohsiung 833, Taiwan.
EM tainyl@hotmail.com; chien_ning_hsu@hotmail.com
RI Hsu, Chien-Ning/GLS-4014-2022; Tain, You-Lin/H-2827-2019
OI Hsu, Chien-Ning/0000-0001-7470-528X; Tain, You-Lin/0000-0002-7059-6407
FU Chang Gung Memorial Hospital, Kaohsiung, Taiwan [CMRPG8G0672,
   CMRPG8F0023, CMRPG8H0081]
FX This work was supported by the Grants CMRPG8G0672, CMRPG8F0023 and
   CMRPG8H0081 from Chang Gung Memorial Hospital, Kaohsiung, Taiwan.
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NR 78
TC 35
Z9 35
U1 0
U2 8
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD SEP
PY 2018
VL 19
IS 9
AR 2584
DI 10.3390/ijms19092584
PG 12
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA HA1OU
UT WOS:000449988100120
PM 30200293
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Eren, E
   Abuhandan, M
   Solmaz, A
   Taskin, A
AF Eren, Erdal
   Abuhandan, Mahmut
   Solmaz, Abdullah
   Taskin, Abdullah
TI Serum Paraoxonase/Arylesterase Activity and Oxidative Stress Status in
   Children with Metabolic Syndrome
SO JOURNAL OF CLINICAL RESEARCH IN PEDIATRIC ENDOCRINOLOGY
LA English
DT Article
DE Metabolic syndrome; obesity; oxidative stress; paraoxonase
ID FATTY LIVER-DISEASE; C-REACTIVE PROTEIN; INSULIN-RESISTANCE; OBESE
   CHILDREN; PARAOXONASE ACTIVITY; CHILDHOOD OBESITY; AUTOMATED-METHOD;
   ADIPOKINE LEVELS; PON1 ACTIVITY; RISK-FACTORS
AB Objective: This study aimed to measure paraoxonase/arylesterase activities and to evaluate the total oxidant and antioxidant capacities in obese children and in children with metabolic syndrome (MetS).
   Methods: A total of 151 children of comparable ages (13.23+/-1.96 years, 13.45+/-1.85 years and 13.95+/-1.31 years) were enrolled in the study. Forty of these were children with MetS, 55 were obese and 56 were healthy controls. Diagnosis of the MetS was made according to International Diabetes Federation criteria. Paraoxonase/arylesterase activities were evaluated by using paraoxon and phenylacetate substrates. Total oxidant status (TOS) and total antioxidant status (TAS) were measured and oxidative stress index (OSI) was estimated by calculation.
   Results: High levels of paraoxonase were detected in the obese group, whereas high levels of arylesterase were detected in both MetS and obese groups. Higher values for TOS, TAS and OSI were found in the MetS group (p<0.05).
   Conclusion: Higher values of mean TOS and OSI in the MetS group than those in the control groups indicate that these parameters may be indicators of future risks such as atherosclerosis in patients with MetS.
C1 [Eren, Erdal] Harran Univ, Fac Med, Dept Pediat Endocrinol, Sanliurfa, Turkey.
   [Abuhandan, Mahmut; Solmaz, Abdullah] Uludag Univ, Fac Med, Dept Pediat, Bursa, Turkey.
   [Taskin, Abdullah] Uludag Univ, Fac Med, Dept Biochem, Bursa, Turkey.
C3 Harran University; Uludag University; Uludag University
RP Eren, E (corresponding author), Uludag Univ, Fac Med, Dept Pediat Endocrinol, Bursa, Turkey.
EM dreeren@gmail.com
RI Eren, Erdal/JPK-3909-2023; Celikk, Hakim/ABF-5740-2020
OI Eren, Erdal/0000-0002-1684-1053
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NR 34
TC 21
Z9 22
U1 0
U2 10
PU GALENOS YAYINCILIK
PI FINDIKZADE
PA ERKAN MOR, MOLLA GURANI CAD 21-1, FINDIKZADE, ISTANBUL 34093, TURKEY
SN 1308-5727
EI 1308-5735
J9 J CLIN RES PEDIATR E
JI J. Clin Res. Pediatr. Endocrinol.
PD SEP
PY 2014
VL 6
IS 3
BP 163
EP 168
DI 10.4274/jcrpe.1454
PG 6
WC Endocrinology & Metabolism; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Pediatrics
GA AY8DK
UT WOS:000347784500005
PM 25241610
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Fan, XD
   Liu, EY
   Freudenreich, O
   Park, JH
   Liu, DT
   Wang, JJ
   Yi, ZH
   Goff, D
   Henderson, DC
AF Fan, Xiaoduo
   Liu, Emily Y.
   Freudenreich, Oliver
   Park, Ju Hyung
   Liu, Dengtang
   Wang, Jijun
   Yi, Zhenghui
   Goff, Donald
   Henderson, David C.
TI Higher white blood cell counts are associated with an increased risk for
   metabolic syndrome and more severe psychopathology in non-diabetic
   patients with schizophrenia
SO SCHIZOPHRENIA RESEARCH
LA English
DT Article
DE White blood cell count; Inflammation; Metabolic syndrome; Schizophrenia
ID LEUKOCYTE COUNT; GLUCOSE-METABOLISM; DOUBLE-BLIND; CSF LEVELS;
   INFLAMMATION; INTERLEUKIN-2; RISPERIDONE; MORTALITY; SYMPTOMS; FLOW
AB Background: Unequivocal evidence has emerged linking inflammation to the risk of metabolic problems. Previous research also has suggested a relationship between inflammation and schizophrenia. The present study examined whether white blood cell count (WBC), a marker of systemic inflammation, is associated with metabolic syndrome and psychiatric symptoms in non-diabetic patients with schizophrenia.
   Methods: Outpatients 19 to 75 years old diagnosed with schizophrenia or schizoaffective disorder participated in a multi-center, cross-sectional study. Vital signs and anthropometric measures were obtained. Fasting blood samples were collected to determine levels of glucose, lipids and WBC. Psychiatric symptoms were assessed using the Brief Psychiatric Rating Scale (BPRS).
   Results: In the sample of 199 patients, multiple logistic regression showed that WBC (log transformed) strongly predicted the condition of metabolic syndrome after potential confounding variables including age, gender, race, age of illness onset, family history of diabetes, smoking status and antipsychotic agent used were taken into consideration (odds ratio 47.2, 95% Cl 3.4-658.7, p = 0.004). On the other hand, significant correlations were found between WBC (log transformed) and BPRS-total score (r = 0.18, p = 0.014), negative symptom score (r = 0.15, p = 0.039) as well as anxious depression factor score (r = 0.21, p = 0.004) after potential confounding variables were taken into consideration.
   Conclusion: This study suggested that WBC, a simple, readily available and inexpensive measure, may potentially be a useful marker to predict an increased risk for metabolic syndrome and more severe psychiatric symptoms in non-diabetic patients with schizophrenia. (C) 2010 Elsevier B.V. All rights reserved.
C1 [Fan, Xiaoduo; Freudenreich, Oliver; Park, Ju Hyung; Goff, Donald; Henderson, David C.] Massachusetts Gen Hosp, Dept Psychiat, Schizophrenia Program, Boston, MA 02114 USA.
   [Fan, Xiaoduo; Freudenreich, Oliver; Goff, Donald; Henderson, David C.] Harvard Univ, Sch Med, Boston, MA USA.
   [Liu, Emily Y.] Partners Community Healthcare Inc, Haverhill, MA USA.
   [Liu, Dengtang; Wang, Jijun; Yi, Zhenghui] Shanghai Mental Hlth Ctr, Shanghai, Peoples R China.
C3 Harvard University; Harvard University Medical Affiliates; Massachusetts
   General Hospital; Harvard University; Harvard Medical School
RP Fan, XD (corresponding author), Freedom Trail Clin, 25 Staniford St, Boston, MA 02114 USA.
EM xfan@partners.org
RI Fan, Xiaoduo/AAV-1268-2020; Wang, Jijun/HTP-0666-2023
OI Fan, Xiaoduo/0000-0003-4299-8924; Liu, Dengtang/0000-0002-0813-6848;
   Henderson, David/0000-0001-8755-4505
FU Eli Lilly and Company; Eli Lilly; AstraZeneca; Bristol-Myer-Squibb;
   Janssen; Pfizer; Cephalon; Organon; Xytis; Wyeth; Forest Labs; Indevus;
   Schering Plough; Novartis; Takeda; Solvay; COVANCE
FX The original study was sponsored by Eli Lilly and Company. Eli Lilly was
   responsible for the collection of the data. However, Eli Lilly was not
   involved in analyzing or interpreting the data, or deciding to submit
   the paper for publication.Dr. Fan has received research support or
   honoraria from Eli Lilly, AstraZeneca, Bristol-Myer-Squibb, Janssen, and
   Pfizer. Dr. Freudenreich has received research support or honoraria from
   AstraZeneca, Bristol-Myer-Squibb, Janssen, Eli Lilly, Cephalon and
   Pfizer. Dr. Goff has received research support or honoraria from
   Organon, Xytis, Wyeth, Forest Labs, Eli Lilly, Pfizer, Indevus, Schering
   Plough, AstraZeneca, Janssen and Bristol-Myer-Squibb, Novartis and
   Cephalon. Dr. Henderson has received research support or honoraria from
   Takeda, Bristol-Myers Squibb, Pfizer, AstraZeneca, Eli Lilly, Solvay,
   Janssen and COVANCE. Drs. E Liu, D Liu, Wang, Vi and Ms. Park report no
   disclosures.
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NR 51
TC 66
Z9 71
U1 0
U2 12
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0920-9964
EI 1573-2509
J9 SCHIZOPHR RES
JI Schizophr. Res.
PD MAY
PY 2010
VL 118
IS 1-3
BP 211
EP 217
DI 10.1016/j.schres.2010.02.1028
PG 7
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 603NE
UT WOS:000278214500031
PM 20189773
DA 2025-06-11
ER

PT J
AU Hong, ST
   Ghandriz, R
   Siddiqi, S
   Zhu, XY
   Saadiq, IM
   Jordan, KL
   Tang, H
   Ali, KA
   Lerman, A
   Eirin, A
   Lerman, LO
AF Hong, Siting
   Ghandriz, Ramyar
   Siddiqi, Sarosh
   Zhu, Xiang-Yang
   Saadiq, Ishran M.
   Jordan, Kyra L.
   Tang, Hui
   Ali, Khaled A.
   Lerman, Amir
   Eirin, Alfonso
   Lerman, Lilach O.
TI Effects of Elamipretide on Autophagy in Renal Cells of Pigs with
   Metabolic Syndrome
SO CELLS
LA English
DT Article
DE kidney; metabolic syndrome; autophagy; mitochondria; inflammation
ID MESENCHYMAL STEM-CELLS; MITOCHONDRIAL DYSFUNCTION; MYOCARDIAL AUTOPHAGY;
   OXIDATIVE STRESS; LIPID-METABOLISM; FATTY KIDNEY; OBESITY; ACTIVATION;
   MECHANISMS; INJURY
AB Autophagy eliminates excessive nutrients and maintains homeostasis. Obesity and metabolic syndrome (MetS) dysregulate autophagy, possibly partly due to mitochondria injury and inflammation. Elamipretide (ELAM) improves mitochondrial function. We hypothesized that MetS blunts kidney autophagy, which ELAM would restore. Domestic pigs were fed a control or MetS-inducing diet for 16 weeks. During the 4 last weeks, MetS pigs received subcutaneous injections of ELAM (0.1 mg/kg/day, MetS + ELAM) or vehicle (MetS), and kidneys were then harvested to measure protein expression of autophagy mediators and apoptosis. Systemic and renal venous levels of inflammatory cytokines were measured to calculate renal release. The function of isolated mitochondria was assessed by oxidative stress, energy production, and pro-apoptotic activity. MetS slightly downregulated renal expression of autophagy mediators including p62, ATG5-12, mTOR, and AMPK vs. control. Increased mitochondrial H2O2 production accompanied decreased ATP production, elevated apoptosis, and renal fibrosis. In MetS + ELAM, mito-protection restored autophagic protein expression, improved mitochondrial energetics, and blunted renal cytokine release and fibrosis. In vitro, mitoprotection restored mitochondrial membrane potential and reduced oxidative stress in injured proximal tubular epithelial cells. Our study suggests that swine MetS mildly affects renal autophagy, possibly secondary to mitochondrial damage, and may contribute to kidney structural damage in MetS.
C1 [Hong, Siting; Ghandriz, Ramyar; Siddiqi, Sarosh; Zhu, Xiang-Yang; Saadiq, Ishran M.; Jordan, Kyra L.; Tang, Hui; Ali, Khaled A.; Eirin, Alfonso; Lerman, Lilach O.] Mayo Clin, Div Nephrol & Hypertens, Rochester, MN 55905 USA.
   [Hong, Siting] Harbin Med Univ, Dept Cardiol, Affiliated Hosp 1, Harbin 150001, Peoples R China.
   [Lerman, Amir] Mayo Clin, Dept Cardiovasc Dis, Rochester, MN 55905 USA.
C3 Mayo Clinic; Harbin Medical University; Mayo Clinic
RP Lerman, LO (corresponding author), Mayo Clin, Div Nephrol & Hypertens, Rochester, MN 55905 USA.
EM lerman.lilach@mayo.edu
RI Lerman, Lilach/M-4962-2017; Eirin, Alfonso/N-9873-2013; Hong,
   Siting/GZK-8698-2022
OI Eirin, Alfonso/0000-0002-3864-9644; Ghandriz, Ramyar/0000-0003-3770-643X
FU Stealth BioTherapeutics; NIH [DK120292, DK122734, HL158691, DK122137,
   AG062104]; National Institute of Diabetes and Digestive and Kidney
   Diseases [R01DK120292] Funding Source: NIH RePORTER; National Institute
   on Aging [R21AG062104] Funding Source: NIH RePORTER
FX This study was partly supported by grants from Stealth BioTherapeutics
   and the NIH (DK120292, DK122734, HL158691, DK122137, and AG062104).
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NR 102
TC 3
Z9 3
U1 0
U2 4
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2073-4409
J9 CELLS-BASEL
JI Cells
PD SEP
PY 2022
VL 11
IS 18
AR 2891
DI 10.3390/cells11182891
PG 16
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA 4T5PQ
UT WOS:000858169300001
PM 36139466
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Xu, LC
   Li, WW
   Chen, Y
   Liu, S
   Liu, GD
   Luo, WH
   Cao, GY
   Wang, SP
AF Xu, Liancheng
   Li, Wenwen
   Chen, Yu
   Liu, Shan
   Liu, Guodong
   Luo, Weihuan
   Cao, Guanyi
   Wang, Shiping
TI Metformin Regulates Cardiac Ferroptosis to Reduce Metabolic
   Syndrome-Induced Cardiac Dysfunction
SO APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
LA English
DT Article
DE Metabolic syndrome; Ferroptosis; Nuclear factor erythroid 2-related
   factor 2; Reactive oxygen species; Mitochondrial damage; Metformin;
   Cardiac dysfunction
ID DAMAGE
AB High-fat diet-induced metabolic syndrome (MetS) is closely associated with cardiac dysfunction. Recent research studies have indicated a potential association between MetS and ferroptosis. Furthermore, metformin can alleviate MetS-induced cardiac ferroptosis. Metformin is a classic biguanide anti-diabetic drug that has protective effects on cardiovascular diseases, which extend beyond its indirect glycemic control. This study aimed to assess whether MetS mediates cardiac ferroptosis, thereby causing oxidative stress and mitochondrial dysfunction. The results revealed that metformin can mitigate cardiac reactive oxygen species and mitochondrial damage, thereby preserving cardiac function. Mechanistic analysis revealed that metformin upregulates the expression of cardiac Nrf2. Moreover, Nrf2 downregulation compromises the cardio-protective effects of metformin. In summary, this study indicated that MetS promotes cardiac ferroptosis, and metformin plays a preventive and therapeutic role, partially through modulation of Nrf2 expression.
C1 [Xu, Liancheng; Chen, Yu; Liu, Shan; Liu, Guodong; Luo, Weihuan; Cao, Guanyi; Wang, Shiping] Suqian First Hosp, Dept Gen Surg, 120 Suzhi Rd, Suqian 223800, Jiangsu, Peoples R China.
   [Li, Wenwen] Suqian First Hosp, Dept Nephrol, Suqian 223800, Peoples R China.
   [Xu, Liancheng] Fujian Med Univ, Fuzhou 350108, Fujian, Peoples R China.
C3 Fujian Medical University
RP Wang, SP (corresponding author), Suqian First Hosp, Dept Gen Surg, 120 Suzhi Rd, Suqian 223800, Jiangsu, Peoples R China.
EM sqyy1035@163.com
RI li, guodong/AAG-3008-2021
FU Suqian SciTech Program
FX No Statement Available
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   Zhou J, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19102863
NR 40
TC 4
Z9 4
U1 2
U2 4
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0273-2289
EI 1559-0291
J9 APPL BIOCHEM BIOTECH
JI Appl. Biochem. Biotechnol.
PD JAN
PY 2025
VL 197
IS 1
BP 179
EP 193
DI 10.1007/s12010-024-05038-7
EA AUG 2024
PG 15
WC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology
GA S4Z2C
UT WOS:001285241300001
PM 39106027
DA 2025-06-11
ER

PT J
AU Yu, JJ
   Zhang, ZH
   Li, CJ
   Zhang, JR
   Ding, ZB
   Zhu, WL
   Wang, Q
AF Yu, Jingjie
   Zhang, Zhihui
   Li, Chunjun
   Zhang, Jiarui
   Ding, Zengbo
   Zhu, Weili
   Wang, Qiang
TI Serum Lipid Concentrations Are Associated With Negative Mental Health
   Outcomes in Healthy Women Aged 35-49 Years
SO FRONTIERS IN PSYCHIATRY
LA English
DT Article
DE mood disorders; psychosocial stress; obesity; body mass index-BMI;
   total-cholesterol; LDL-cholesterol; triglyceride; middle-aged women
ID MAJOR DEPRESSIVE DISORDER; RETIREMENT; SEVERITY; OBESITY; RISK
AB Background: Although the relevant underlying biological mechanisms are still lacking, mental disorders have been closely associated with several metabolic abnormalities including high rates of obesity and metabolic syndrome especially in vulnerable populations. Therefore, the current study aims to examine how metabolic parameters increase the risk for developing mood disorders in individuals stratified by gender and age.Methods: In a routine physical examination, 319 healthy participants were recruited and assigned to six different groups according to age (young adults: 25-34 Y, middle age: 35-49 Y, and older age: 50-65 Y) in both males and females. A linear regression and bivariate correlation analysis were used to analyze the relationship between mood health outcomes measured by the Kessler 10 Psychological Distress Scale (K10) and the metabolic function.Results: The results demonstrated that there was a significant association between K10 scores and metabolic parameters, including Body Mass Index (BMI), total-, LDL-cholesterol, and triglyceride. Furthermore, poor mental health (higher K10 scores) was observed in individuals with increased BMI, total-, LDL-cholesterol, and triglyceride levels particularly in middle-aged women relative to other groups.Limitations: This is a cross-sectional study with a small sample size and lacks longitudinal follow-up evidence and preventive interventions and therefore could not provide the causal inference of metabolic pathophysiology on the increased sensitivity to mental disorders.Conclusions: The potential association suggests that targeting of the metabolic parameters might give us a better understanding of the underlying mechanisms of psychiatric diseases and provide preventive strategies and potential treatment for those with metabolic disturbances especially in middle-aged females.
C1 [Yu, Jingjie; Zhang, Jiarui] Tianjin Union Med Ctr, Dept Psychiat & Psychol, Tianjin, Peoples R China.
   [Zhang, Zhihui] Peking Univ Third Hosp, Stomatol Dept, Beijing, Peoples R China.
   [Li, Chunjun] Tianjin Union Med Ctr, Hlth Examinat Ctr, Tianjin, Peoples R China.
   [Ding, Zengbo; Zhu, Weili] Peking Univ, Natl Inst Drug Dependence, Beijing Key Lab Drug Dependence, Beijing, Peoples R China.
   [Wang, Qiang] Shanghai Univ Med & Hlth Sci, Affiliated Zhoupu Hosp, Shanghai, Peoples R China.
C3 Peking University; Shanghai University of Medicine & Health Sciences
RP Zhu, WL (corresponding author), Peking Univ, Natl Inst Drug Dependence, Beijing Key Lab Drug Dependence, Beijing, Peoples R China.; Wang, Q (corresponding author), Shanghai Univ Med & Hlth Sci, Affiliated Zhoupu Hosp, Shanghai, Peoples R China.
EM zhu_wl@bjmu.edu.cn; wangq_21@sumhs.edu.cn
OI Wang, qiang/0009-0008-3738-9001
FU National Natural Science Foundation of China [81800983]; Key Basic
   Research Project of Shandong Provincial Natural Science Foundation
   [ZR2019ZD27]; Peking University Medicine Seed Fund for Interdisciplinary
   Research [BMU2020MX022, 71006Y2337]; Key Clinical Projects of Peking
   University Third Hospital [BYSYZD2019035]; State Key Laboratory of
   Environmental Chemistry and Ecotoxicology, Research Center for
   Eco-Environmental Sciences, Chinese Academy of Sciences [KF2020-18]
FX This work was supported by the National Natural Science Foundation of
   China (No. 81800983), Key Basic Research Project of Shandong Provincial
   Natural Science Foundation (ZR2019ZD27), Peking University Medicine Seed
   Fund for Interdisciplinary Research (Nos. BMU2020MX022 and 71006Y2337),
   Key Clinical Projects of Peking University Third Hospital (No.
   BYSYZD2019035), and State Key Laboratory of Environmental Chemistry and
   Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese
   Academy of Sciences (KF2020-18).
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NR 20
TC 3
Z9 3
U1 0
U2 8
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-0640
J9 FRONT PSYCHIATRY
JI Front. Psychiatry
PD NOV 2
PY 2021
VL 12
AR 773338
DI 10.3389/fpsyt.2021.773338
PG 6
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA WZ1CN
UT WOS:000719711100001
PM 34795602
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Gumbarewicz, E
   Jarzab, A
   Stepulak, A
   Kukula-Koch, W
AF Gumbarewicz, Ewelina
   Jarzab, Agata
   Stepulak, Andrzej
   Kukula-Koch, Wirginia
TI Zingiber officinale Rosc. in the Treatment of Metabolic Syndrome
   Disorders-A Review of In Vivo Studies
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE ginger; inflammation; obesity; cardiovascular system; molecular biology;
   Zingiberaceae
ID GINGER EXTRACT; OXIDATIVE STRESS; LIPID PROFILE; NANOPARTICLES;
   INFLAMMATION; PREVENTION; EXPRESSION; RECEPTOR; COLITIS; OBESITY
AB Inflammation is a protective reaction of the innate immune system as a response to imbalances caused by a specific stimulus, a disease or a pathogen. A prolonged inflammatory condition may lead to the development of metabolic syndrome, which affects more than one-fourth of the world's population. This condition leads to the development of multi-organ disorders based on disrupted blood lipid and sugar levels, hypertension and oxidative stress. The review aims to present Zingiber officinale Rosc. as a plant that exhibits a variety of healing properties and restores the organism's equilibrium. Ginger (GI) rhizomes have been commonly used in traditional medicine to treat arthritis, stomach ache, nonalcoholic fatty liver disease, rheumatism, nervous system syndromes, asthma, diabetes and nausea caused by pregnancy or chemotherapy. This review gathers together data from in vivo experiments related to the application of ginger for the treatment of inflammatory conditions, obesity, diabetes and other related disorders as a consequence of metabolic syndrome, including the confirmed molecular mechanisms of action.
C1 [Gumbarewicz, Ewelina; Jarzab, Agata; Stepulak, Andrzej] Med Univ Lublin, Dept Biochem & Mol Biol, Chodzki 1, PL-20093 Lublin, Poland.
   [Kukula-Koch, Wirginia] Med Univ Lublin, Dept Pharmacognosy Med Plants Garden, Chodzki 1, PL-20093 Lublin, Poland.
C3 Medical University of Lublin; Medical University of Lublin
RP Stepulak, A (corresponding author), Med Univ Lublin, Dept Biochem & Mol Biol, Chodzki 1, PL-20093 Lublin, Poland.
EM andrzej.stepulak@umlub.pl
RI Kukula-Koch, Wirginia/I-5468-2019
OI Kukula-Koch, Wirginia/0000-0001-7076-600X; Stepulak,
   Andrzej/0000-0002-1872-394X
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NR 69
TC 6
Z9 6
U1 0
U2 10
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD DEC
PY 2022
VL 23
IS 24
AR 15545
DI 10.3390/ijms232415545
PG 15
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 7E4MD
UT WOS:000901143400001
PM 36555184
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Falcao, A
   Bullón, P
AF Falcao, Artur
   Bullon, Pedro
TI A review of the influence of periodontal treatment in systemic diseases
SO PERIODONTOLOGY 2000
LA English
DT Review
DE cardiovascular diseases; diabetes; periodontal disease; periodontal
   treatment; pregnancy outcomes; psoriasis; respiratory diseases;
   rheumatoid arthritis; systemic diseases
ID CORONARY-HEART-DISEASE; LOW-BIRTH-WEIGHT; RHEUMATOID-ARTHRITIS; GLYCEMIC
   CONTROL; PUSTULOSIS PALMARIS; PREGNANCY OUTCOMES; METABOLIC SYNDROME;
   PRETERM BIRTH; PORPHYROMONAS-GINGIVALIS; OXIDATIVE STRESS
C1 [Falcao, Artur; Bullon, Pedro] Univ Seville, Dent Sch, Dept Periodontol, Seville, Spain.
C3 University of Sevilla
RP Bullón, P (corresponding author), Univ Seville, Dent Sch, Dept Periodontol, Seville, Spain.
RI Bullon, Pedro/E-6319-2010
OI Bullon, Pedro/0000-0003-4873-4196; Falcao, Artur/0009-0007-9646-8554
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NR 143
TC 91
Z9 95
U1 1
U2 37
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0906-6713
EI 1600-0757
J9 PERIODONTOL 2000
JI Periodontol. 2000
PD FEB
PY 2019
VL 79
IS 1
BP 117
EP 128
DI 10.1111/prd.12249
PG 12
WC Dentistry, Oral Surgery & Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dentistry, Oral Surgery & Medicine
GA HP6TW
UT WOS:000461820100007
PM 30892764
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Johnson, RJ
   Nakagawa, T
   Sanchez-Lozada, LG
   Shafiu, M
   Sundaram, S
   Le, M
   Ishimoto, T
   Sautin, YY
   Lanaspa, MA
AF Johnson, Richard J.
   Nakagawa, Takahiko
   Gabriela Sanchez-Lozada, L.
   Shafiu, Mohamed
   Sundaram, Shikha
   Le, Myphuong
   Ishimoto, Takuji
   Sautin, Yuri Y.
   Lanaspa, Miguel A.
TI Sugar, Uric Acid, and the Etiology of Diabetes and Obesity
SO DIABETES
LA English
DT Article
ID INCOMPLETE INTESTINAL-ABSORPTION; EXCESSIVE FRUCTOSE INTAKE; C-REACTIVE
   PROTEIN; SERUM URATE LEVELS; SWEETENED BEVERAGES; METABOLIC SYNDROME;
   OXIDATIVE STRESS; NITRIC-OXIDE; FATTY LIVER; INSULIN-RESISTANCE
AB The intake of added sugars, such as from table sugar (sucrose) and high-fructose corn syrup has increased dramatically in the last hundred years and correlates closely with the rise in obesity, metabolic syndrome, and diabetes. Fructose is a major component of added sugars and is distinct from other sugars in its ability to cause intracellular ATP depletion, nucleotide turnover, and the generation of uric acid. In this article, we revisit the hypothesis that it is this unique aspect of fructose metabolism that accounts for why fructose intake increases the risk for metabolic syndrome. Recent studies show that fructose-induced uric acid generation causes mitochondrial oxidative stress that stimulates fat accumulation independent of excessive caloric intake. These studies challenge the long-standing dogma that a calorie is just a calorie and suggest that the metabolic effects of food may matter as much as its energy content. The discovery that fructose-mediated generation of uric acid may have a causal role in diabetes and obesity provides new insights into pathogenesis and therapies for this important disease.
C1 [Johnson, Richard J.; Nakagawa, Takahiko; Le, Myphuong; Ishimoto, Takuji; Lanaspa, Miguel A.] Univ Colorado Denver, Div Kidney Dis & Hypertens, Aurora, CO USA.
   [Johnson, Richard J.] Dept Veteran Affairs, Eastern Colorado Hlth Care Syst, Div Nephrol, Denver, CO USA.
   [Nakagawa, Takahiko] Kyoto Univ, Med Innovat Ctr, TMK Project, Kyoto, Japan.
   [Gabriela Sanchez-Lozada, L.] Inst Nacl Cardiol I Ch, Lab Renal Physiopathol, Mexico City, DF, Mexico.
   [Gabriela Sanchez-Lozada, L.] Inst Nacl Cardiol I Ch, Dept Nephrol, Mexico City, DF, Mexico.
   [Shafiu, Mohamed] Renal Associates, San Antonio, TX USA.
   [Shafiu, Mohamed] Renal Associates, Del Rio, TX USA.
   [Sundaram, Shikha] Childrens Hosp, Div Pediat Gastroenterol, Aurora, CO USA.
   [Sautin, Yuri Y.] Univ Florida, Div Nephrol Hypertens & Renal Transplantat, Gainesville, FL USA.
C3 Children's Hospital Colorado; University of Colorado System; University
   of Colorado Anschutz Medical Campus; Kyoto University; National
   Institute of Cardiology - Mexico; National Institute of Cardiology -
   Mexico; Children's Hospital Colorado; State University System of
   Florida; University of Florida
RP Johnson, RJ (corresponding author), Univ Colorado Denver, Div Kidney Dis & Hypertens, Aurora, CO USA.
EM richard.johnson@ucdenver.edu
RI Sanchez-Lozada, Laura/AAS-2104-2021; Lanaspa, Miguel/AAO-4971-2020;
   Ishimoto, Takuji/M-4873-2014
OI Le, MyPhuong/0000-0002-1136-3419; Sanchez-Lozada,
   Laura-Gabriela/0000-0003-0348-9617; Ishimoto, Takuji/0000-0002-9861-5331
FU ADA Basic Science Award [7-12-BS-16]
FX Support for this study was provided by ADA Basic Science Award
   7-12-BS-16 to Y.Y.S.
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NR 102
TC 578
Z9 636
U1 7
U2 281
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0012-1797
EI 1939-327X
J9 DIABETES
JI Diabetes
PD OCT
PY 2013
VL 62
IS 10
BP 3307
EP 3315
DI 10.2337/db12-1814
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 222RG
UT WOS:000324748200010
PM 24065788
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU García-Arroyo, FE
   Gonzaga-Sánchez, G
   Tapia, E
   Muñoz-Jiménez, I
   Manterola-Romero, L
   Osorio-Alonso, H
   Arellano-Buendía, AS
   Pedraza-Chaverri, J
   Roncal-Jiménez, CA
   Lanaspa, MA
   Johnson, RJ
   Sánchez-Lozada, LG
AF Garcia-Arroyo, Fernando E.
   Gonzaga-Sanchez, Guillermo
   Tapia, Edilia
   Munoz-Jimenez, Itzel
   Manterola-Romero, Lino
   Osorio-Alonso, Horacio
   Arellano-Buendia, Abraham S.
   Pedraza-Chaverri, Jose
   Roncal-Jimenez, Carlos A.
   Lanaspa, Miguel A.
   Johnson, Richard J.
   Sanchez-Lozada, Laura Gabriela
TI Osthol Ameliorates Kidney Damage and Metabolic Syndrome Induced by a
   High-Fat/High-Sugar Diet
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE metabolic syndrome; renal lipotoxicity; fructokinase; coumarins
AB Excessive intake of fructose results in metabolic syndrome (MS) and kidney damage, partly mediated by its metabolism by fructokinase-C or ketohexokinase-C (KHK-C). Osthol has antioxidant properties, is capable of regulating adipogenesis, and inhibits KHK-C activity. Here, we examined the potential protective role of osthol in the development of kidney disease induced by a Western (high-fat/high-sugar) diet. Control rats fed with a high-fat/high-sugar diet were compared with two groups that also received two different doses of osthol (30 mg/kg/d or 40 mg/kg/d body weight BW). A fourth group served as a normal control and received regular chow. At the end of the follow-up, kidney function, metabolic markers, oxidative stress, and lipogenic enzymes were evaluated. The Western diet induced MS (hypertension, hyperglycemia, hypertriglyceridemia, obesity, hyperuricemia), a fall in the glomerular filtration rate, renal tubular damage, and increased oxidative stress in the kidney cortex, with increased expression of lipogenic enzymes and increased kidney KHK expression. Osthol treatment prevented the development of MS and ameliorated kidney damage by inhibiting KHK activity, preventing oxidative stress via nuclear factor erythroid 2-related factor (Nrf2) activation, and reducing renal lipotoxicity. These data suggest that the nutraceutical osthol might be an ancillary therapy to slow the progression of MS and kidney damage induced by a Western diet.
C1 [Garcia-Arroyo, Fernando E.; Gonzaga-Sanchez, Guillermo; Tapia, Edilia; Munoz-Jimenez, Itzel; Manterola-Romero, Lino; Osorio-Alonso, Horacio; Arellano-Buendia, Abraham S.; Sanchez-Lozada, Laura Gabriela] INC Ignacio Chavez, Dept Cardiorenal Physiopathol, Mexico City 14080, DF, Mexico.
   [Pedraza-Chaverri, Jose] Natl Autonomous Univ Mexico UNAM, Fac Chem, Dept Biol, Mexico City 04510, DF, Mexico.
   [Roncal-Jimenez, Carlos A.; Lanaspa, Miguel A.; Johnson, Richard J.] Univ Colorado, Div Renal Dis & Hypertens, Aurora, CO 80045 USA.
C3 Universidad Nacional Autonoma de Mexico; University of Colorado System;
   University of Colorado Anschutz Medical Campus
RP García-Arroyo, FE; Sánchez-Lozada, LG (corresponding author), INC Ignacio Chavez, Dept Cardiorenal Physiopathol, Mexico City 14080, DF, Mexico.
EM enrique.garcia@cardiologia.org.mx; ggonzaga49@gmail.com;
   edilia.tapia@cardiologia.org.mx; itzelmj0707@gmail.com;
   linomr9@gmail.com; horacio.osorio@cardiologia.org.mx;
   abraham.arellano@cardiologia.org.mx; pedraza@unam.mx;
   CARLOS.RONCAL@cuanschutz.edu; Miguel.LanaspaGarcia@cuanschutz.edu;
   Richard.Johnson@cuanschutz.edu; laura.sanchez@cardiologia.org.mx
RI Sanchez-Lozada, Laura/AAS-2104-2021; Lanaspa, Miguel/AAO-4971-2020;
   Alonso, Horacio/T-3946-2019
OI Tapia, Edilia/0000-0001-7955-816X; Johnson, Richard/0000-0003-3312-8193;
   Garcia Arroyo, Fernando Enrique/0000-0003-1545-9765; Sanchez-Lozada,
   Laura-Gabriela/0000-0003-0348-9617; Osorio Alonso,
   Horacio/0000-0002-9238-4202
FU Fondos de Gasto Directo autorizado
FX The Instituto Nacional de Cardiologia Ignacio Chavez supported OPEN
   ACCESS funding. This research was supported by the Fondos de Gasto
   Directo autorizado a la Subdireccion de Investigacion Basica del
   Instituto Nacional de Cardiologia Ignacio Chavez.
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NR 61
TC 18
Z9 22
U1 1
U2 21
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD MAR
PY 2021
VL 22
IS 5
AR 2431
DI 10.3390/ijms22052431
PG 17
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA QV9RP
UT WOS:000628299600001
PM 33670975
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU De Bona, KS
   Bonfanti, G
   Bitencourt, PER
   Cargnelutti, LO
   da Silva, PS
   De Lucca, L
   Pimentel, VC
   Tatsch, E
   Gonçalves, TL
   Premaor, M
   Moresco, RN
   Moretto, MB
AF De Bona, Karine S.
   Bonfanti, Gabriela
   Bitencourt, Paula E. R.
   Cargnelutti, Lariane O.
   da Silva, Priscila S.
   De Lucca, Leidiane
   Pimentel, Victor C.
   Tatsch, Etiane
   Goncalves, Thissiane L.
   Premaor, Melissa
   Moresco, Rafael N.
   Moretto, Maria Beatriz
TI Butyrylcholinesterase and γ-Glutamyltransferase Activities and Oxidative
   Stress Markers Are Altered in Metabolic Syndrome, But Are Not Affected
   by Body Mass Index
SO INFLAMMATION
LA English
DT Article
DE body mass index; butyrylcholinesterase; metabolic syndrome; nitric
   oxide; gamma-glutamyltransferase
ID DIPEPTIDYL-PEPTIDASE-IV; C-REACTIVE PROTEIN; ADENOSINE-DEAMINASE; SERUM
   BUTYRYLCHOLINESTERASE; INSULIN-RESISTANCE; PLASMA; RISK;
   ATHEROSCLEROSIS; DETERMINANTS; INFLAMMATION
AB Metabolic syndrome (MetS) leads to changes in enzymatic activities, oxidative and inflammatory parameters. Adenosine deaminase (ADA), dipeptidyl peptidase IV (DPP-IV), butyrylcholinesterase (BuChE) and gamma-glutamyltransferase (gamma-GT) activities, C-reactive protein (hsCRP) and nitric oxide levels (NOx), as well as oxidative stress markers were analyzed in 39 subjects with MetS and 48 controls. Also, the influence of body mass index (BMI) and anthropometric measurements were evaluated. Disturbances in antioxidant defenses and higher gamma-GT and BuChE activities, NOx and hsCRP levels were observed in subjects with MetS. These findings remained associated with MetS after adjustment for BMI, except for hsCRP. ADA was correlated with age, insulin levels and HOMA-IR index in MetS. DPP-IV and total cholesterol (TC), BuChE activity and TC, and VIT C and hsCRP levels also were correlated. The analyzed parameters may reflect the inflammatory state of the MetS, and could contribute to prevention and control of various aspects of this syndrome.
C1 [De Bona, Karine S.; Bonfanti, Gabriela; Premaor, Melissa; Moresco, Rafael N.; Moretto, Maria Beatriz] Fed Univ Santa Maria UFSM, Postgrad Program Pharmacol, Dept Clin & Toxicol Anal, Ctr Hlth Sci, BR-97105900 Santa Maria, RS, Brazil.
   [Bitencourt, Paula E. R.; Cargnelutti, Lariane O.; da Silva, Priscila S.; De Lucca, Leidiane; Tatsch, Etiane; Goncalves, Thissiane L.; Moresco, Rafael N.; Moretto, Maria Beatriz] Univ Fed Santa Maria, Postgrad Program Pharmaceut Sci, Santa Maria, RS, Brazil.
   [Pimentel, Victor C.] Univ Fed Santa Maria, Dept Chem, Santa Maria, RS, Brazil.
C3 Universidade Federal de Santa Maria (UFSM); Universidade Federal de
   Santa Maria (UFSM); Universidade Federal de Santa Maria (UFSM)
RP Moretto, MB (corresponding author), Fed Univ Santa Maria UFSM, Postgrad Program Pharmacol, Dept Clin & Toxicol Anal, Ctr Hlth Sci, BR-97105900 Santa Maria, RS, Brazil.
EM beatriz@smail.ufsm.br
RI Pimentel, Victor/F-4579-2014; Premaor, Melissa/K-7401-2016; Moresco,
   Rafael/K-6118-2017
OI Bernasconi, Thissiane/0000-0003-2409-8105; Bonfanti-Azzolin,
   Gabriela/0000-0003-2602-6092; Bitencourt, Paula/0000-0001-7828-518X;
   Premaor, Melissa/0000-0002-0770-9202; Moresco,
   Rafael/0000-0003-3072-5080
FU Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq);
   Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES);
   Federal University of Santa Maria (UFSM), RS, Brazil
FX The authors wish to thank the Conselho Nacional de Desenvolvimento
   Cientifico e Tecnologico (CNPq), Coordenacao de Aperfeicoamento de
   Pessoal de Nivel Superior (CAPES) and Federal University of Santa Maria
   (UFSM), RS, Brazil, for support in this study. Also, we thank all the
   volunteers who participated in this study.
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NR 48
TC 13
Z9 14
U1 0
U2 6
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0360-3997
EI 1573-2576
J9 INFLAMMATION
JI Inflammation
PD DEC
PY 2013
VL 36
IS 6
BP 1539
EP 1547
DI 10.1007/s10753-013-9697-9
PG 9
WC Cell Biology; Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Immunology
GA 248IM
UT WOS:000326692200043
PM 23933911
DA 2025-06-11
ER

PT J
AU Garruti, G
   Cotecchia, S
   Giampetruzzi, F
   Giorgino, F
   Giorgino, R
AF Garruti, Gabriella
   Cotecchia, Susanna
   Giampetruzzi, Federica
   Giorgino, Francesco
   Giorgino, Riccardo
TI Neuroendocrine deregulation of food intake, adipose tissue and the
   gastrointestinal system in obesity and metabolic syndrome
SO JOURNAL OF GASTROINTESTINAL AND LIVER DISEASES
LA English
DT Article
DE obesity; sympathetic nervous system; metabolic syndrome; adrenergic
   receptors; prohormone convertase 1/3; type 4 melanocortin receptor
ID EARLY-ONSET OBESITY; MELANOCORTIN-4 RECEPTOR; REGIONAL DIFFERENCES;
   UNCOUPLING PROTEIN; INSULIN-RESISTANCE; MISSENSE MUTATION;
   MESSENGER-RNA; FAT TISSUE; LIPOLYSIS; LEPTIN
AB Obesity is an excess of fat mass. Fat mass is an energy depot but also an endocrine organ. A deregulation of the sympathetic nervous system (SNS) might produce obesity. Stress exaggerates diet-induced obesity. After stress, SNS fibers release neuropeptide Y (NPY) which directly increases visceral fat mass producing a metabolic syndrome (MbS)-like phenotype. Adrenergic receptors are the main regulators of lipolysis. In severe obesity, we demonstrated that the adrenergic receptor subtypes are differentially expressed in different fat depots. Liver and visceral fat share a common sympathetic pathway, which might explain the low-grade inflammation which simultaneously Occurs in liver and fat of the obese with MbS. The neuroendocrine melanocortinergic system and gastric ghrelin are also greatly deregulated in obesity. A specific mutation in the type 4 melanocortin receptor induces early obesity onset, hyperphagia and insulin-resistance. Nonetheless, it was recently discovered that a mutation in the prohormone convertase 1/3 Simultaneously produces severe gastrointestinal dysfunctions and obesity.
C1 [Garruti, Gabriella; Giampetruzzi, Federica; Giorgino, Francesco; Giorgino, Riccardo] Univ Bari, Sch Med, Unit Internal Med Endocrinol & Metab Dis, Dept Emergency & Organ Transplantat, I-70124 Bari, Italy.
   [Cotecchia, Susanna] Univ Bari, Dept Gen & Environm Physiol, I-70124 Bari, Italy.
   [Cotecchia, Susanna] Univ Lausanne, Dept Pharmacol & Toxicol, Lausanne, Switzerland.
C3 Universita degli Studi di Bari Aldo Moro; Universita degli Studi di Bari
   Aldo Moro; University of Lausanne
RP Garruti, G (corresponding author), Univ Bari, Sch Med, Unit Internal Med Endocrinol & Metab Dis, Dept Emergency & Organ Transplantat, Piazza G Cesarc,11, I-70124 Bari, Italy.
EM g.garruti@cndo.uniba.it
RI Giorgino, Francesco/K-7262-2016
OI Giorgino, Francesco/0000-0001-7372-2678; Garruti,
   Gabriella/0000-0001-7875-7239
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   2005, ASIANET         0914
NR 34
TC 26
Z9 29
U1 0
U2 5
PU MEDICAL UNIV PRESS
PI CLUJ-NAPOCA
PA 3RD MEDICAL CLINIC, STR CROITORILOR NO 19-21, CLUJ-NAPOCA, 400162,
   ROMANIA
SN 1841-8724
EI 1842-1121
J9 J GASTROINTEST LIVER
JI J. Gastrointest. Liver Dis.
PD JUN
PY 2008
VL 17
IS 2
BP 193
EP 198
PG 6
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 345BD
UT WOS:000258970100012
PM 18568142
DA 2025-06-11
ER

PT J
AU Herrera, MI
   Udovin, LD
   Toro-Urrego, N
   Kusnier, CF
   Luaces, JP
   Otero-Losada, M
   Capani, F
AF Herrera, Maria I.
   Udovin, Lucas D.
   Toro-Urrego, Nicolas
   Kusnier, Carlos F.
   Luaces, Juan P.
   Otero-Losada, Matilde
   Capani, Francisco
TI Neuroprotection Targeting Protein Misfolding on Chronic Cerebral
   Hypoperfusion in the Contextof Metabolic Syndrome
SO FRONTIERS IN NEUROSCIENCE
LA English
DT Review
DE metabolic syndrome; chronic cerebral hypoperfusion; neuroprotection;
   protein misfolding; endoplasmic reticulum stress; chaperones;
   neurodegenerative diseases
ID ENDOPLASMIC-RETICULUM STRESS; UBIQUITIN-PROTEASOME SYSTEM;
   ALZHEIMERS-DISEASE; NEURODEGENERATIVE DISEASES; BLOOD-FLOW; COGNITIVE
   DYSFUNCTION; O-GLCNACYLATION; RAT MODEL; ARTERIOVENOUS-MALFORMATIONS;
   DIABETES-MELLITUS
AB Metabolic syndrome (MetS) is a cluster of risk factors that lead to microvascular dysfunction and chronic cerebral hypoperfusion (CCH). Long-standing reduction in oxygen and energy supply leads to brain hypoxia and protein misfolding, thereby linking CCH to Alzheimer's disease. Protein misfolding results in neurodegeneration as revealed by studying different experimental models of CCH. Regulating proteostasis network through pathways like the unfolded protein response (UPR), the ubiquitin-proteasome system (UPS), chaperone-mediated autophagy (CMA), and macroautophagy emerges as a novel target for neuroprotection. Lipoxin A4 methyl ester, baclofen, URB597, N-stearoyl-L-tyrosine, and melatonin may pose potential neuroprotective agents for rebalancing the proteostasis network under CCH. Autophagy is one of the most studied pathways of proteostatic cell response against the decrease in blood supply to the brain though the role of the UPR-specific chaperones and the UPS system in CCH deserves further research. Pharmacotherapy targeting misfolded proteins at different stages in the proteostatic pathway might be promising in treating cognitive impairment following CCH.
C1 [Herrera, Maria I.] Univ Catolica Argentina, Fac Psicol & Psicopedag, Ctr Invest Psicol & Psicopedag, Buenos Aires, DF, Argentina.
   [Herrera, Maria I.; Udovin, Lucas D.; Toro-Urrego, Nicolas; Kusnier, Carlos F.; Luaces, Juan P.; Otero-Losada, Matilde; Capani, Francisco] Univ Buenos Aires UBA CONICET, Inst Invest Cardiol ININCA, Buenos Aires, DF, Argentina.
   [Capani, Francisco] Univ Catolica Argentina, Fac Med, Buenos Aires, DF, Argentina.
   [Capani, Francisco] Univ Autonoma Chile, Santiago, Chile.
C3 Pontificia Universidad Catolica Argentina; University of Buenos Aires;
   Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET);
   Pontificia Universidad Catolica Argentina; Universidad Autonoma de Chile
RP Capani, F (corresponding author), Univ Buenos Aires UBA CONICET, Inst Invest Cardiol ININCA, Buenos Aires, DF, Argentina.; Capani, F (corresponding author), Univ Catolica Argentina, Fac Med, Buenos Aires, DF, Argentina.; Capani, F (corresponding author), Univ Autonoma Chile, Santiago, Chile.
EM franciscocapani@hotmail.com
RI capani, Francisco/D-9781-2016; Otero-Losada, Matilde/J-3050-2019;
   Luaces, Juan/NDT-5206-2025
FU CONICET [0779]; University of Buenos Aires (UBACyT) [20720130100014BA];
   IBRO-PROLAB; FONCyT [PICD 0031 2016-2020]
FX This work was supported by grants to FC from the CONICET (PIP 2016-2019
   no. 0779), the University of Buenos Aires (UBACyT 2014-2017 no.
   20720130100014BA), IBRO-PROLAB 2017 and FONCyT (PICD 0031 2016-2020).
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NR 93
TC 12
Z9 13
U1 0
U2 10
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1662-453X
J9 FRONT NEUROSCI-SWITZ
JI Front. Neurosci.
PD MAY 31
PY 2018
VL 12
AR 339
DI 10.3389/fnins.2018.00339
PG 9
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA GH7BG
UT WOS:000433597700001
PM 29904335
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Innes, KE
   Vincent, HK
   Taylor, AG
AF Innes, Kim E.
   Vincent, Heather K.
   Taylor, Ann Gill
TI CHRONIC STRESS AND INSULIN RESISTANCE-RELATED INDICES OF CARDIOVASCULAR
   DISEASE RISK, PART I: NEUROPHYSIOLOGICAL RESPONSES AND PATHOLOGICAL
   SEQUELAE
SO ALTERNATIVE THERAPIES IN HEALTH AND MEDICINE
LA English
DT Article
AB Cardiovascular disease (CVD) is the leading cause of death and disability in the industrialized world, and the prevalence is increasing rapidly among developing nations. The rising prevalence of CVD worldwide may be attributed in large part to specific atherogenic changes in insulin resistance, adiposity, lipid profiles, and other indices of insulin resistance syndrome (IRS), a cluster of metabolic and hemodynamic abnormalities that are strongly predictive of CVD. A growing body of research suggests that chronic psychosocial stress and related factors significantly contribute to the pathogenesis of IRS-related abnormalities, associated insulin-resistant states, and CVD, in part by promoting dysregulation of the sympathoadrenal system and hypothalamic-pituitary-adrenal axis. In this article, we review the literature supporting the relationships between these factors, outline the neurophysiologic responses to chronic stress, and discuss the pathways by which chronic or recurrent psychosocial stress may lead to a destructive cascade of neuroendocrine, metabolic, inflammatory, and neuropsychological changes that fosters the development of IRS and, ultimately, CVD. (Altern Ther Health Med. 2007;13(4):46-52.)
C1 [Innes, Kim E.; Taylor, Ann Gill] Univ Virginia Hlth Syst, Ctr Study Complementary & Alternat Therapies, Charlottesville, VA USA.
   [Innes, Kim E.] Univ Virginia Hlth Syst, Dept Phys Med & Rehabil, Charlottesville, VA USA.
   [Vincent, Heather K.] Univ Florida, Dept Orthoped & Rehabil, Gainesville, FL USA.
C3 University of Virginia; University of Virginia (UVA) Health System;
   University of Virginia; University of Virginia (UVA) Health System;
   State University System of Florida; University of Florida
RP Innes, KE (corresponding author), Univ Virginia Hlth Syst, Ctr Study Complementary & Alternat Therapies, Charlottesville, VA USA.
RI Vincent, Heather/ABH-4566-2020; Taylor, Ann/IQT-7642-2023
OI Vincent, Heather/0000-0003-2177-1683
FU University of Virginia Institute on Aging; National Center for
   Complementary and Alternative Medicine [T32-AT-00052, R21AT002982];
   National Center for Research Resources [M01 RR 00030-32]
FX This work was made possible by the University of Virginia Institute on
   Aging and the National Center for Complementary and Alternative Medicine
   (grant numbers T32-AT-00052 and R21AT002982), and the National Center
   for Research Resources (grant number M01 RR 00030-32). The contents are
   solely the responsibility of the authors and do not represent the
   official views of the University of Virginia, the NCCAM, or the National
   Institutes of Health.
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NR 167
TC 32
Z9 38
U1 0
U2 1
PU INNOVISION COMMUNICATIONS
PI ALISO VIEJO
PA 101 COLUMBIA, ALISO VIEJO, CA 92656 USA
SN 1078-6791
J9 ALTERN THER HEALTH M
JI Altern. Ther. Health Med.
PD JUL-AUG
PY 2007
VL 13
IS 4
BP 46
EP 52
PG 7
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA V12YM
UT WOS:000207634500007
PM 17658122
DA 2025-06-11
ER

PT J
AU Restivo, I
   Attanzio, A
   Tesoriere, L
   Allegra, M
AF Restivo, Ignazio
   Attanzio, Alessandro
   Tesoriere, Luisa
   Allegra, Mario
TI Suicidal Erythrocyte Death in Metabolic Syndrome
SO ANTIOXIDANTS
LA English
DT Review
DE eryptosis; metabolic syndrome; diabetes; dyslipidemia; hypertension;
   obesity; atherosclerosis; vascular damage; oxidative stress; endothelial
   dysfunction
ID ADVANCED GLYCATION ENDPRODUCTS; INSULIN-RESISTANCE; OXIDATIVE STRESS;
   ADIPOSE-TISSUE; OBESITY; MECHANISMS; ERYPTOSIS; DISEASE; METHYLGLYOXAL;
   PATHOGENESIS
AB Eryptosis is a coordinated, programmed cell death culminating with the disposal of cells without disruption of the cell membrane and the release of endocellular oxidative and pro-inflammatory milieu. While providing a convenient form of death for erythrocytes, dysregulated eryptosis may result in a series of detrimental and harmful pathological consequences highly related to the endothelial dysfunction (ED). Metabolic syndrome (MetS) is described as a cluster of cardiometabolic factors (hyperglycemia, dyslipidemia, hypertension and obesity) that increases the risk of cardiovascular complications such as those related to diabetes and atherosclerosis. In the light of the crucial role exerted by the eryptotic process in the ED, the focus of the present review is to report and discuss the involvement of eryptosis within MetS, where vascular complications are utterly relevant. Current knowledge on the mechanisms leading to eryptosis in MetS-related conditions (hyperglycemia, dyslipidemia, hypertension and obesity) will be analyzed. Moreover, clinical evidence supporting or proposing a role for eryptosis in the ED, associated to MetS cardiovascular complications, will be discussed.
C1 [Restivo, Ignazio; Attanzio, Alessandro; Tesoriere, Luisa; Allegra, Mario] Univ Palermo, Dipartimento Sci & Tecnol Biol Chim & Farmaceut, I-90128 Palermo, Italy.
C3 University of Palermo
RP Tesoriere, L; Allegra, M (corresponding author), Univ Palermo, Dipartimento Sci & Tecnol Biol Chim & Farmaceut, I-90128 Palermo, Italy.
EM ignazio.restivo@unipa.it; alessandro.attanzio@unipa.it;
   luisa.tesoriere@unipa.it; mario.allegra@unipa.it
RI Allegra, Mario/AAG-3256-2019; Restivo, Ignazio/AAW-8282-2020
OI Allegra, Mario/0000-0002-5846-1868; tesoriere,
   Luisa/0000-0002-7980-7530; RESTIVO, IGNAZIO/0000-0003-1833-2356
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NR 101
TC 24
Z9 24
U1 0
U2 5
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD FEB
PY 2021
VL 10
IS 2
AR 154
DI 10.3390/antiox10020154
PG 13
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA QM8PF
UT WOS:000622034900001
PM 33494379
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Biccirè, FG
   Bucci, T
   Menichelli, D
   Cammisotto, V
   Pignatelli, P
   Carnevale, R
   Pastori, D
AF Biccire, Flavio Giuseppe
   Bucci, Tommaso
   Menichelli, Danilo
   Cammisotto, Vittoria
   Pignatelli, Pasquale
   Carnevale, Roberto
   Pastori, Daniele
TI Mediterranean Diet: A Tool to Break the Relationship of Atrial
   Fibrillation with the Metabolic Syndrome and Non-Alcoholic Fatty Liver
   Disease
SO NUTRIENTS
LA English
DT Article
DE diet; atrial fibrillation; metabolic syndrome; NAFLD
ID OXIDATIVE STRESS; CHOCOLATE CONSUMPTION; ALCOHOL-CONSUMPTION; VITAMIN-K;
   CARDIOVASCULAR EVENTS; DANISH DIET; RISK; ASSOCIATION; FISH; PREVALENCE
AB Atrial fibrillation (AF) is the most common supraventricular arrhythmia associated with increased cardiovascular and non-cardiovascular morbidity and mortality. As multiple factors may predispose the onset of AF, the prevention of the occurrence, recurrence and complications of this arrhythmia is still challenging. In particular, a high prevalence of cardio-metabolic comorbidities such as the metabolic syndrome (MetS) and in its hepatic manifestation, the non-alcoholic fatty liver disease (NAFLD), have been described in the AF population. A common pathogenetic mechanism linking AF, MetS and NAFLD is represented by oxidative stress. For this reason, in the past decades, numerous studies have investigated the effect of different foods/nutrients with antioxidant properties for the prevention of, and their therapeutic role is still unclear. In this narrative comprehensive review, we will summarize current evidence on (1) the association between AF, MetS and NAFLD (2) the antioxidant role of Mediterranean Diet and its components for the prevention of AF and (3) the effects of Mediterranean Diet on MetS components and NAFLD.
C1 [Biccire, Flavio Giuseppe; Bucci, Tommaso] Sapienza Univ Rome, Dept Gen & Specialized Surg Paride Stefanini, I-00161 Rome, Italy.
   [Menichelli, Danilo; Cammisotto, Vittoria; Pignatelli, Pasquale; Pastori, Daniele] Sapienza Univ Rome, Dept Clin Internal Anesthesiol & Cardiovasc Sci, I-00161 Rome, Italy.
   [Pignatelli, Pasquale; Carnevale, Roberto] Mediterranea Cardioctr, I-80122 Naples, Italy.
   [Carnevale, Roberto] Sapienza Univ Rome, Dept Med Surg Sci & Biotechnol, I-04100 Latina, Italy.
C3 Sapienza University Rome; Sapienza University Rome; Sapienza University
   Rome
RP Pastori, D (corresponding author), Sapienza Univ Rome, Dept Clin Internal Anesthesiol & Cardiovasc Sci, I-00161 Rome, Italy.
EM flaviogiuseppe.biccire@uniroma1.it; tommaso.bucci@uniroma1.it;
   danilo.menichelli@uniroma1.it; vittoria.cammisotto@uniroma1.it;
   pasquale.pignatelli@uniroma1.it; roberto.carnevale@uniroma1.it;
   daniele.pastori@uniroma1.it
RI Biccirè, Flavio Giuseppe/CAH-5345-2022; Carnevale,
   Roberto/JMC-1138-2023; Carnevale, Roberto/K-1472-2016; Menichelli,
   Danilo/W-5498-2018; pastori, daniele/J-7087-2016; pignatelli,
   pasquale/K-2116-2016; Bucci, Tommaso/ABA-4162-2021
OI Cammisotto, Vittoria/0000-0003-1966-5945; Carnevale,
   Roberto/0000-0002-6216-9595; Menichelli, Danilo/0000-0001-9467-5903;
   pastori, daniele/0000-0001-6357-5213; pignatelli,
   pasquale/0000-0002-2265-7455; Bucci, Tommaso/0000-0003-2895-6234
FU Sapienza Progetto Medio di Ateneo 2019 [000031_19_RS_PAST
   ORI_PROGETTI_MEDI _2019]
FX The article was supported by Sapienza Progetto Medio di Ateneo 2019
   granted to Daniele Pastori (grant number 000031_19_RS_PAST
   ORI_PROGETTI_MEDI _2019).
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NR 105
TC 11
Z9 11
U1 1
U2 12
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD MAR
PY 2022
VL 14
IS 6
AR 1260
DI 10.3390/nu14061260
PG 16
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 0D9QN
UT WOS:000776323100001
PM 35334916
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Rusu, ARG
   Tartau, LM
   Statescu, C
   Boanca, M
   Poroch, V
   Lupusoru, RV
   Dima, N
   Badescu, C
   Rezus, E
   Rezus, C
   Lupusoru, CE
AF Rusu, Ana Roxana Ganceanu
   Tartau, Liliana Mititelu
   Statescu, Cristian
   Boanca, Mihaela
   Poroch, Vladimir
   Lupusoru, Raoul Vasile
   Dima, Nicoleta
   Badescu, Codruta
   Rezus, Elena
   Rezus, Ciprian
   Lupusoru, Catalina Elena
TI Study of Dynamics of Immunobiochemical Parameters and Pharmacological
   Interferences in the Metabolic Syndrome
SO REVISTA DE CHIMIE
LA English
DT Article
DE metabolic syndrome; immuno-biochemical markers; cortisol; interleukins
ID OXIDATIVE STRESS; OBESITY; INFLAMMATION; POPULATION; MANAGEMENT;
   CHILDHOOD; IMPACT; MODEL; IL-6
AB The metabolic syndrome (MetS) represents a frequent disorder of the present age, with increased global prevalence, with complex etiopathogenesis and physiopathology, with great impact upon the patients, society and economy and which often is difficult to treat. The main aim of the study was the evaluation of the pharmacodynamic effects of associated angiotensin-converting enzyme (ACE) inhibitors with nonsteroidal anti-inflammatory drugs (NSAIDs) on blood pressure values and markers of oxidative stress in rats with MetS. Material and methods: 9 groups of 6 Wistar rats weighing between 150-200g with uniform gender distribution were subjected to cholesterol diet. During 4 weeks, their exercise capacities were analyzed over a 10-minute interval after administration of the test substances. Results: All groups who received cholesterol showed significant increases in serum cortisoL The group receiving Enalapril noted the highest levels of superoxide dismutase (SOD). Conclusions: Comparing the results obtained in this study with the literature, it was noted that the administration of ACE and / or NSAIDs significantly improves the process of chronic inflammation.
C1 [Rusu, Ana Roxana Ganceanu; Tartau, Liliana Mititelu; Statescu, Cristian; Boanca, Mihaela; Poroch, Vladimir; Lupusoru, Raoul Vasile; Dima, Nicoleta; Badescu, Codruta; Rezus, Elena; Rezus, Ciprian; Lupusoru, Catalina Elena] Grigore T Popa Univ Med & Pharm, 16 Univ Str, Iasi 700115, Romania.
   [Statescu, Cristian] Prof George Georgescu Cardiovasc Dis Inst, Dept Med Cardiol, 50 Carol 1 Blvd, Iasi 700503, Romania.
   [Poroch, Vladimir] Reg Inst Oncol, 2-4 G Ral Berthelot Str, Iasi 700483, Romania.
   [Dima, Nicoleta; Badescu, Codruta; Rezus, Ciprian] Sf Spiridon Clin Emergency Hosp, Dept Internal Med 3, 1 Independentei Sq, Iasi 700111, Romania.
   [Rezus, Elena] Clin Rehabil Hosp, Dept Clin Rheumatol 1, 14 Pantelimon Halipa Str, Iasi 700614, Romania.
C3 Grigore T Popa University of Medicine & Pharmacy; Regional Institute of
   Oncology IASI
RP Boanca, M; Poroch, V; Rezus, C (corresponding author), Grigore T Popa Univ Med & Pharm, 16 Univ Str, Iasi 700115, Romania.; Poroch, V (corresponding author), Reg Inst Oncol, 2-4 G Ral Berthelot Str, Iasi 700483, Romania.
EM mboanca33@yahoo.com; vlader2000@yahoo.com; ciprianrezus@yahoo.com
RI Lupusoru, Raoul/MTF-9730-2025; STATESCU, Cristian/ABH-3610-2020;
   Badescu, Minerva/ABC-4333-2021; MITITELU-TARTAU, LILIANA/AEO-8191-2022;
   Rezus, Elena/K-2137-2018; Dima, Nicoleta/LUZ-9206-2024; Poroch,
   Vladimir/K-2611-2013; REZUS, CIPRIAN/A-1905-2015
OI Dima, Nicoleta/0000-0002-8276-835X; Lupusoru,
   Raoul-Vasile/0000-0003-2653-4919; Poroch, Vladimir/0000-0002-2503-5395;
   REZUS, CIPRIAN/0000-0003-1155-7325
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NR 32
TC 10
Z9 10
U1 0
U2 10
PU REVISTA CHIMIE SRL
PI BUCURESTI
PA CALES PLEVNEI NR 139A, SECTOR 6, BUCURESTI, ROMANIA
SN 0034-7752
J9 REV CHIM-BUCHAREST
JI Rev. Chim.
PD JUN
PY 2018
VL 69
IS 6
BP 1493
EP 1497
PG 5
WC Chemistry, Multidisciplinary; Engineering, Chemical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Engineering
GA GM7TK
UT WOS:000438397400041
DA 2025-06-11
ER

PT J
AU Yeh, CW
   Liu, HK
   Lin, LC
   Liou, KT
   Huang, YC
   Lin, CH
   Tzeng, TT
   Shie, FS
   Tsay, HJ
   Shiao, YJ
AF Yeh, Chih-Wen
   Liu, Hui-Kang
   Lin, Lie-Chwen
   Liou, Kou-Tong
   Huang, Yung-Cheng
   Lin, Chien-Hung
   Tzeng, Tsai-Teng
   Shie, Feng-Shiun
   Tsay, Huey-Jen
   Shiao, Young-Ji
TI Xuefu Zhuyu decoction ameliorates obesity, hepatic steatosis,
   neuroinflammation, amyloid deposition and cognition impairment in
   metabolically stressed APPswe/PS1dE9 mice
SO JOURNAL OF ETHNOPHARMACOLOGY
LA English
DT Article
DE Metabolic stresses; Alzheimer's disease; Xuefu Zhuyu decoction; Amyloid
   plaque; Glia; Cognitive dysfunction
ID MOUSE MODEL; NESTING-BEHAVIOR; IN-VIVO; INFLAMMATION; ASTROCYTES;
   DYSFUNCTION; GLUCOSE
AB Ethnopharmacological relevance: Metabolic syndrome and vascular dysfunction was suggested to be the risk factors for Alzheimer's disease (AD). Xuefu Zhuyu decoction (XZD) is a traditional Chinese medicine used to treat metabolic syndrome and cardiac-cerebral vascular disease. The effects of XZD on ameliorating metabolic syndrome, amyloid-related pathologies and cognitive impairment in an animal model of AD with metabolic stress was investigated.
   Materials and method: The animal model of AD with metabolic stress was created by administrating high-fat diet and a low-dose injection of streptozotocin prior to the appearance of senile plaques in APP/PS1 transgenic mice. The diabesity-associated metabolic changes and AD-related pathological alterations were examined.
   Results: We found that XZD reduced body weight, insulin and leptin level, HOMA-IR, hepatic triglyceride, serum A(342 in the metabolic stressed AD animal. XZD also ameliorated oral glucose tolerant, A beta deposition, astrocyte and microglia activation in the vicinity of plaques, and nesting behavior in the metabolic stressed AD animal.
   Conclusion: The results of this study suggest that XZD is able to reduce the peripheral metabolic stress mediated vascular hypoperfusion, neuroinflammation and AD-related pathology in APP/PSI mice.
C1 [Yeh, Chih-Wen; Lin, Chien-Hung; Tsay, Huey-Jen] Natl Yang Ming Univ, Sch Life Sci, Brain Res Ctr, Inst Neurosci, 155 Sec 2,LiNung St, Taipei 112, Taiwan.
   [Liu, Hui-Kang; Lin, Lie-Chwen; Shiao, Young-Ji] Natl Res Inst Chinese Med, Minist Hlth & Welf, 155-1 Sec 2,LiNung St, Taipei 112, Taiwan.
   [Liu, Hui-Kang] Taipei Med Univ, PhD Program Clin Drug Discovery Bot Herbs, Taipei, Taiwan.
   [Liou, Kou-Tong] Chinese Culture Univ, Dept Chinese Martial Arts, Taipei, Taiwan.
   [Liou, Kou-Tong] Chinese Culture Univ, Grad Inst Sport Coaching Sci, Taipei, Taiwan.
   [Huang, Yung-Cheng] Cheng Hsin Gen Hosp, Dept Phys Med & Rehabil, Taipei, Taiwan.
   [Tzeng, Tsai-Teng; Shiao, Young-Ji] Natl Yang Ming Univ, Inst Biopharmaceut Sci, Taipei, Taiwan.
   [Shie, Feng-Shiun] Natinal Hlth Res Inst, Ctr Neuropsychiat Res, Zhunan, Taiwan.
C3 National Yang Ming Chiao Tung University; National Research Institute of
   Chinese Medicine; Taipei Medical University; Chinese Culture University;
   Chinese Culture University; Cheng Hsin General Hospital; National Yang
   Ming Chiao Tung University
RP Tsay, HJ (corresponding author), Natl Yang Ming Univ, Sch Life Sci, Brain Res Ctr, Inst Neurosci, 155 Sec 2,LiNung St, Taipei 112, Taiwan.; Shiao, YJ (corresponding author), Natl Res Inst Chinese Med, Minist Hlth & Welf, 155-1 Sec 2,LiNung St, Taipei 112, Taiwan.; Shie, FS (corresponding author), Natinal Hlth Res Inst, Ctr Neuropsychiat Res, Zhunan, Taiwan.
EM flow5168@hotmail.com; hk.liu@nricm.edu.tw; Iclin@nricmedu.tw;
   lgt@facuity.pecu.adua.tw; jeremy0681@gmail.com; whitebrake@hotmail.com;
   fly23242530@hotmail.com; fshie@ahri.org.tw; hjtsay@ym.edu.tw;
   yshiao@nricm.edu.tw
RI Huang, Yung/KEJ-3323-2024; Shiao, Young-Ji/AAA-9647-2022; Shie,
   Feng-Shiun/E-3836-2010
OI Yeh, Chih-Wen/0000-0002-3833-2364
FU Ministry of Science and Technology [MOST-102-2320-B-077-003,
   MOST-103-2320-B-077-004-MY3, MOST-103-2311-B-010-008, MM10201-0274];
   National Health Research Institutes and Central Government ST grant,
   Taiwan [106-1901-01-10-02]
FX The work was supported by grants from the Ministry of Science and
   Technology (MOST-102-2320-B-077-003; MOST-103-2320-B-077-004-MY3;
   MOST-103-2311-B-010-008 and MM10201-0274). and National Health Research
   Institutes and Central Government S&T grant, Taiwan (106-1901-01-10-02)
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NR 53
TC 24
Z9 26
U1 4
U2 32
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0378-8741
J9 J ETHNOPHARMACOL
JI J. Ethnopharmacol.
PD SEP 14
PY 2017
VL 209
BP 50
EP 61
DI 10.1016/j.jep.2017.07.036
PG 12
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA FH9OX
UT WOS:000411542700006
PM 28743670
DA 2025-06-11
ER

PT J
AU Tarr, D
   Graham, D
   Roy, LA
   Holmes, WM
   McCabe, C
   Macrae, IM
   Muir, KW
   Dewar, D
AF Tarr, David
   Graham, Delyth
   Roy, Lisa A.
   Holmes, William M.
   McCabe, Christopher
   Macrae, I. Mhairi
   Muir, Keith W.
   Dewar, Deborah
TI Hyperglycemia accelerates apparent diffusion coefficient-defined lesion
   growth after focal cerebral ischemia in rats with and without features
   of metabolic syndrome
SO JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
LA English
DT Article
DE animal models; diffusion-weighted MRI; focal ischemia; glucose;
   hyperglycemia
ID POSTSTROKE HYPERGLYCEMIA; MYOCARDIAL-INFARCTION; GLUCOSE CONCENTRATION;
   DIABETES-MELLITUS; OXIDATIVE STRESS; ARTERY OCCLUSION; ACUTE STROKE;
   RISK-FACTORS; COMPONENTS; MANAGEMENT
AB Poststroke hyperglycemia is associated with a poor outcome yet clinical management is inadequately informed. We sought to determine whether clinically relevant levels of hyperglycemia exert detrimental effects on the early evolution of focal ischemic brain damage, as determined by magnetic resonance imaging, in normal rats and in those modeling the 'metabolic syndrome'. Wistar Kyoto (WKY) or fructose-fed spontaneously hypertensive stroke-prone (ffSHRSP) rats were randomly allocated to groups for glucose or vehicle administration before permanent middle cerebral artery occlusion. Diffusion-weighted imaging was carried out over the first 4 hours after middle cerebral artery occlusion and lesion volume calculated from apparent diffusion coefficient maps. Infarct volume and immunostaining for markers of oxidative stress were measured in the fixed brain sections at 24 hours. Hyperglycemia rapidly exacerbated early ischemic damage in both WKY and ffSHRSP rats but increased infarct volume only in WKY rats. There was only limited evidence of oxidative stress in hyperglycemic animals. Acute hyperglycemia, at clinically relevant levels, exacerbates early ischemic damage in both normal and metabolic syndrome rats. Management of hyperglycemia may have greatest benefit when performed in the acute phase after stroke in the absence or presence of comorbidities.
C1 [Tarr, David; Roy, Lisa A.; Holmes, William M.; McCabe, Christopher; Macrae, I. Mhairi; Muir, Keith W.; Dewar, Deborah] Univ Glasgow, Inst Neurosci & Psychol, Coll Med Vet & Life Sci, Glasgow G61 1QH, Lanark, Scotland.
   [Graham, Delyth] Univ Glasgow, BHF Glasgow Cardiovasc Res Ctr, Inst Cardiovasc & Med Sci, Glasgow G61 1QH, Lanark, Scotland.
C3 University of Glasgow; University of Glasgow
RP Dewar, D (corresponding author), Univ Glasgow, Inst Neurosci & Psychol, Coll Med Vet & Life Sci, Garscube Estate, Glasgow G61 1QH, Lanark, Scotland.
EM Deborah.Dewar@.glasgow.ac.uk
RI Muir, Keith/A-7670-2011; McCabe, Christopher/E-2051-2016; holmes,
   william/AAP-3417-2021
OI McCabe, Chris/0000-0003-3111-031X; holmes, william/0000-0002-0942-215X
FU Chief Scientist Office (Scotland); Medical Research Council, UK;
   Scottish Imaging Network: A Platform for Scientific Excellence; Medical
   Research Council PhD studentship
FX Financial support: Chief Scientist Office (Scotland); Medical Research
   Council, UK; Scottish Imaging Network: A Platform for Scientific
   Excellence. Funded by the Chief Scientist Office (Scotland); Medical
   Research Council PhD studentship (DT) and the Scottish Imaging Network:
   A Platform for Scientific Excellence (KWM).
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NR 40
TC 14
Z9 15
U1 0
U2 8
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 0271-678X
J9 J CEREBR BLOOD F MET
JI J. Cereb. Blood Flow Metab.
PD OCT
PY 2013
VL 33
IS 10
BP 1556
EP 1563
DI 10.1038/jcbfm.2013.107
PG 8
WC Endocrinology & Metabolism; Hematology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Hematology; Neurosciences & Neurology
GA 228PV
UT WOS:000325199600010
PM 23838826
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Ibitoye, OB
   Ajiboye, TO
AF Ibitoye, Oluwayemisi B.
   Ajiboye, Taofeek O.
TI Dietary phenolic acids reverse insulin resistance, hyperglycaemia,
   dyslipidaemia, inflammation and oxidative stress in high-fructose
   diet-induced metabolic syndrome rats
SO ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
LA English
DT Article
DE Phenolic acids; blood glucose; insulin resistance; hyperlipidaemia;
   antioxidants; pro-inflammatory cytokines; metabolic hormones
ID FERULIC ACID; ANIMAL-MODELS; ANTIOXIDANT; GLUCOSE; OBESITY;
   SUPPLEMENTATION; MICE; LINK
AB This study investigated the influence of caffeic, ferulic, gallic and protocatechuic acids on high-fructose diet-induced metabolic syndrome in rats. Oral administration of the phenolic acids significantly reversed high-fructose diet-mediated increase in body mass index and blood glucose. Furthermore, phenolic acids restored high-fructose diet-mediated alterations in metabolic hormones (insulin, leptin and adiponectin). Similarly, elevated tumour necrosis factor-alpha, interleukin-6 and -8 were significantly lowered. Administration of phenolic acids restored High-fructose diet-mediated increase in the levels of lipid parameters and indices of atherosclerosis, cardiac and cardiovascular diseases. High-fructose diet-mediated decrease in activities of antioxidant enzymes (superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase and glucose 6-phosphate dehydrogenase) and increase in oxidative stress biomarkers (reduced glutathione, lipid peroxidation products, protein oxidation and fragmented DNA) were significantly restored by the phenolic acids. The result of this study shows protective influence of caffeic acid, ferulic acid, gallic acid and protocatechuic acid in high-fructose diet-induced metabolic syndrome.
C1 [Ibitoye, Oluwayemisi B.] Al Hikmah Univ, Dept Biol Sci, Ilorin, Nigeria.
   [Ajiboye, Taofeek O.] Nile Univ Nigeria, Coll Hlth Sci, Dept Med Biochem, Antioxidants Redox Biol & Toxicol Res Grp, Abuja, Nigeria.
RP Ajiboye, TO (corresponding author), Nile Univ Nigeria, Coll Hlth Sci, Dept Med Biochem, Antioxidants Redox Biol & Toxicol Res Grp, Fct Abuja, Nigeria.
EM ajiboyeyong@yahoo.com
RI Ajiboye, Taofeek/H-5383-2011
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NR 47
TC 50
Z9 50
U1 1
U2 28
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1381-3455
EI 1744-4160
J9 ARCH PHYSIOL BIOCHEM
JI Arch. Physiol. Biochem.
PD OCT 20
PY 2018
VL 124
IS 5
BP 410
EP 417
DI 10.1080/13813455.2017.1415938
PG 8
WC Biochemistry & Molecular Biology; Biophysics; Endocrinology &
   Metabolism; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Endocrinology &
   Metabolism; Physiology
GA GW9KQ
UT WOS:000447305900005
DA 2025-06-11
ER

PT J
AU Robeva, R
   Nedyalkova, M
   Kirilov, G
   Elenkova, A
   Zacharieva, S
   Kudlak, B
   Jatkowska, N
   Simeonov, V
AF Robeva, Ralitsa
   Nedyalkova, Miroslava
   Kirilov, Georgi
   Elenkova, Atanaska
   Zacharieva, Sabina
   Kudlak, Blazej
   Jatkowska, Natalia
   Simeonov, Vasil
TI Multivariate Statistical Approach for Nephrines in Women with Obesity
SO MOLECULES
LA English
DT Article
DE metanephrine; normetanephrine; diabetes; obesity; hypertension; cluster
   analyses; exploratory data analysis
ID METABOLIC SYNDROME; EPINEPHRINE; GLUCOSE; DYSFUNCTION; MORTALITY
AB Catecholamines are physiological regulators of carbohydrate and lipid metabolism during stress, but their chronic influence on metabolic changes in obese patients is still not clarified. The present study aimed to establish the associations between the catecholamine metabolites and metabolic syndrome (MS) components in obese women as well as to reveal the possible hidden subgroups of patients through hierarchical cluster analysis and principal component analysis. The 24-h urine excretion of metanephrine and normetanephrine was investigated in 150 obese women (54 non diabetic without MS, 70 non-diabetic with MS and 26 with type 2 diabetes). The interrelations between carbohydrate disturbances, metabolic syndrome components and stress response hormones were studied. Exploratory data analysis was used to determine different patterns of similarities among the patients. Normetanephrine concentrations were significantly increased in postmenopausal patients and in women with morbid obesity, type 2 diabetes, and hypertension but not with prediabetes. Both metanephrine and normetanephrine levels were positively associated with glucose concentrations one hour after glucose load irrespectively of the insulin levels. The exploratory data analysis showed different risk subgroups among the investigated obese women. The development of predictive tools that include not only traditional metabolic risk factors, but also markers of stress response systems might help for specific risk estimation in obesity patients.
C1 [Robeva, Ralitsa; Kirilov, Georgi; Elenkova, Atanaska; Zacharieva, Sabina] Med Univ Sofia, Fac Med, Dept Endocrinol, USHATE Acad Iv Penchev, 2 Zdrave Str, Sofia 1431, Bulgaria.
   [Nedyalkova, Miroslava] Univ Sofia St Kl Ohridski, Fac Chem & Pharm, Dept Inorgan Chem, Sofia 1164, Bulgaria.
   [Kudlak, Blazej; Jatkowska, Natalia] Gdansk Univ Technol, Fac Chem, Dept Analyt Chem, 11-12 Narutowicza, PL-80233 Gdansk, Poland.
   [Simeonov, Vasil] Univ Sofia St Kl Ohridski, Fac Chem & Pharm, Dept Analyt Chem, Sofia 1164, Bulgaria.
C3 Medical University Sofia; University of Sofia; Fahrenheit Universities;
   Gdansk University of Technology; University of Sofia
RP Nedyalkova, M (corresponding author), Univ Sofia St Kl Ohridski, Fac Chem & Pharm, Dept Inorgan Chem, Sofia 1164, Bulgaria.
EM rali_robeva@yahoo.com; miroslava.nedyalkova@unifr.ch; drgkirilov@abv.bg;
   atanaskae@gmail.com; zacharieva67@gmail.com; blakudla@pg.edu.pl;
   natjatko@pg.edu.pl; vsimeonov@chem.uni-sofia.bg
RI Zacharieva, Sabina/GQO-9261-2022; Elenkova, Atanaska/O-6029-2018;
   Nedyalkova, Miroslava/AAU-1615-2020; Robeva, Ralitsa/GPG-1043-2022;
   Jatkowska, Natalia/AAY-8462-2020
OI Zacharieva, Sabina/0000-0001-6087-7136; Kudlak,
   Blazej/0000-0002-2237-2927; Jatkowska, Natalia/0000-0001-8268-3287;
   Nedyalkova, Miroslava/0000-0003-0793-3340; Simeonov,
   Vasil/0000-0003-1164-9561
FU Medical University-Sofia [D125/02.05.2017]; BSF [KP-06/OPR
   03-14-2018-BSF]
FX This research was funded by Medical University-Sofia, Grant 2017,
   D125/02.05.2017 and BSF, grant number KP-06/OPR 03-14-2018-BSF.
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NR 24
TC 1
Z9 1
U1 0
U2 0
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1420-3049
J9 MOLECULES
JI Molecules
PD MAR
PY 2021
VL 26
IS 5
AR 1393
DI 10.3390/molecules26051393
PG 13
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA QW1NR
UT WOS:000628424800001
PM 33807567
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Luque-Contreras, D
   Carvajal, K
   Toral-Rios, D
   Franco-Bocanegra, D
   Campos-Peña, V
AF Luque-Contreras, Diana
   Carvajal, Karla
   Toral-Rios, Danira
   Franco-Bocanegra, Diana
   Campos-Pena, Victoria
TI Oxidative Stress and Metabolic Syndrome: Cause or Consequence of
   Alzheimer's Disease?
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Review
ID CULTURED NEURONAL CELLS; APOLIPOPROTEIN-E; AMYLOID-BETA; CEREBROVASCULAR
   DYSFUNCTION; MOUSE MODEL; MITOCHONDRIAL DYSFUNCTION; NEUROFIBRILLARY
   TANGLES; METHIONINE RESIDUE-35; COGNITIVE IMPAIRMENT; LIPID-PEROXIDATION
AB Alzheimer's disease (AD) is a major neurodegenerative disease affecting the elderly. Clinically, it is characterized by a progressive loss of memory and cognitive function. Neuropathologically, it is characterized by the presence of extracellular beta-amyloid (A beta) deposited as neuritic plaques (NP) and neurofibrillary tangles (NFT) made of abnormal and hyperphosphorylated tau protein. These lesions are capable of generating the neuronal damage that leads to cell death and cognitive failure through the generation of reactive oxygen species (ROS). Evidence indicates the critical role of A beta metabolism in prompting the oxidative stress observed in AD patients. However, it has also been proposed that oxidative damage precedes the onset of clinical and pathological AD symptoms, including amyloid-beta deposition, neurofibrillary tangle formation, vascular malfunction, metabolic syndrome, and cognitive decline. This paper provides a brief description of the three main proteins associated with the development of the disease (A beta, tau, and ApoE) and describes their role in the generation of oxidative stress. Finally, we describe the mitochondrial alterations that are generated by A beta and examine the relationship of vascular damage which is a potential prognostic tool of metabolic syndrome. In addition, new therapeutic approaches targeting ROS sources and metabolic support were reported.
C1 [Luque-Contreras, Diana] Univ Autonoma Coahuila, Fac Ciencias Quim, Saltillo, Coahuila, Mexico.
   [Carvajal, Karla] Inst Nacl Pediat, Lab Nutr Expt, Mexico City 04530, DF, Mexico.
   [Toral-Rios, Danira] Inst Politecn Nacl, Ctr Invest & Estudios Avanzados, Dept Fisiol Biofis & Neurociencias, Mexico City 07360, DF, Mexico.
   [Franco-Bocanegra, Diana] Univ Nacl Autonoma Mexico, Mexico City 04510, DF, Mexico.
   [Campos-Pena, Victoria] Inst Nacl Neurol & Neurocirugia Manuel Velasco Su, Lab Expt Enfermedades Neurodegenerat, Mexico City 14269, DF, Mexico.
C3 Universidad Autonoma de Coahuila; CINVESTAV - Centro de Investigacion y
   de Estudios Avanzados del Instituto Politecnico Nacional; Instituto
   Politecnico Nacional - Mexico; Universidad Nacional Autonoma de Mexico
RP Campos-Peña, V (corresponding author), Inst Nacl Neurol & Neurocirugia Manuel Velasco Su, Lab Expt Enfermedades Neurodegenerat, Insurgentes 3877, Mexico City 14269, DF, Mexico.
EM neurovcp@ymail.com
RI CAMPOS-PEÑA, VICTORIA/AAR-6968-2021; Toral-Rios, Danira/J-7671-2018
OI Toral-Rios, Danira/0000-0001-5156-6969; CARVAJAL,
   KARLA/0000-0002-5522-3266; Franco Bocanegra, Diana
   Karina/0000-0001-6267-1975; CAMPOS-PENA, VICTORIA/0000-0001-8282-7543
FU SEP-CONACYT [157548]
FX This work was supported by a Grant from SEP-CONACYT no. 157548.
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NR 96
TC 122
Z9 135
U1 1
U2 26
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PY 2014
VL 2014
AR 497802
DI 10.1155/2014/497802
PG 11
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA 303WS
UT WOS:000330706500001
PM 24683436
OA hybrid, Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Diwan, V
   Poudyal, H
   Brown, L
AF Diwan, Vishal
   Poudyal, Hemant
   Brown, Lindsay
TI Piperine Attenuates Cardiovascular, Liver and Metabolic Changes in High
   Carbohydrate, High Fat-Fed Rats
SO CELL BIOCHEMISTRY AND BIOPHYSICS
LA English
DT Article
DE Piperine; Metabolic syndrome; Rats
ID ANTIOXIDANT STATUS; BLOOD-PRESSURE; DIET; EFFICACY; NIGRUM
AB Black pepper is used worldwide to enhance food flavor. We investigated dietary supplementation with piperine, the active principle of black pepper, to high carbohydrate, high fat (HCHF) diet-fed rats as a model of human metabolic syndrome. Rats were fed with either HCHF diet (carbohydrate, 52%; fat, 24%; 25% fructose in drinking water) or cornstarch (CS) diet for a total of 16 weeks. Diets of the treatment groups (CS + piperine and HCHF + piperine) were supplemented with piperine for the last 8 weeks of this protocol. After 16 weeks, rats fed with HCHF diet developed hypertension, elevated oxidative stress and inflammation-induced cardiac changes (infiltration of inflammatory cells in heart, increase in count and degranulation of mast cells in heart, cardiac fibrosis and increase in ventricular stiffness), reduced responsiveness of aortic rings, impaired glucose tolerance, abdominal obesity together with liver fibrosis, fat deposition and increased plasma liver enzymes. Supplementation with piperine (375 mg/kg food; approximately 30 mg/kg/day) in HCHF-fed rats normalized blood pressure, improved glucose tolerance and reactivity of aortic rings, reduced plasma parameters of oxidative stress and inflammation, attenuated cardiac and hepatic inflammatory cell infiltration and fibrosis and improved liver function. These changes clearly suggest that piperine reduces symptoms of human metabolic syndrome in HCHF-fed rats by reducing inflammation and oxidative stress.
C1 [Diwan, Vishal; Poudyal, Hemant; Brown, Lindsay] Univ Queensland, Sch Biomed Sci, Brisbane, Qld, Australia.
   [Brown, Lindsay] Univ So Queensland, Dept Biol & Phys Sci, Toowoomba, Qld 4350, Australia.
C3 University of Queensland; University of Southern Queensland
RP Brown, L (corresponding author), Univ So Queensland, Dept Biol & Phys Sci, Toowoomba, Qld 4350, Australia.
EM Lindsay.Brown@usq.edu.au
RI Poudyal, Hemant/HOH-9324-2023
CR Aktoz M, 2007, INT J CARDIOL, V120, P344, DOI 10.1016/j.ijcard.2006.10.010
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NR 34
TC 42
Z9 46
U1 0
U2 19
PU HUMANA PRESS INC
PI TOTOWA
PA 999 RIVERVIEW DRIVE SUITE 208, TOTOWA, NJ 07512 USA
SN 1085-9195
EI 1559-0283
J9 CELL BIOCHEM BIOPHYS
JI Cell Biochem. Biophys.
PD NOV
PY 2013
VL 67
IS 2
SI SI
BP 297
EP 304
DI 10.1007/s12013-011-9306-1
PG 8
WC Biochemistry & Molecular Biology; Biophysics; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Cell Biology
GA 242YP
UT WOS:000326282900010
PM 22038304
DA 2025-06-11
ER

PT J
AU Ameringer, S
   Elswick, RK
   Menzies, V
   Robins, JL
   Starkweather, A
   Walter, J
   Gentry, AE
   Jallo, N
AF Ameringer, Suzanne
   Elswick, R. K., Jr.
   Menzies, Victoria
   Robins, Jo Lynne
   Starkweather, Angela
   Walter, Jeanne
   Gentry, Amanda Elswick
   Jallo, Nancy
TI Psychometric Evaluation of the Patient-Reported Outcomes Measurement
   Information System Fatigue-Short Form Across Diverse Populations
SO NURSING RESEARCH
LA English
DT Article
DE cardiometabolic risk; common data elements; fatigue; fibromyalgia;
   pregnancy; PROMIS; psychometrics; sickle cell disease
ID SICKLE-CELL-DISEASE; CANCER-RELATED FATIGUE; BIOBEHAVIORAL FACTORS;
   RHEUMATOID-ARTHRITIS; VALIDATION; DEPRESSION; SCALE; SYMPTOM; WOMEN;
   RELIABILITY
AB The need for reliable, valid tools to measure patient-reported outcomes (PROs) is critical both for research and for evaluating treatment effects in practice. The Patient-Reported Outcomes Measurement Information System Fatigue-Short Form v1.0-Fatigue 7a (PROMIS F-SF) has had limited psychometric evaluation in various populations.
   Objectives: The aim of the study is to examine psychometric properties of PROMIS F-SF item responses across various populations.
   Methods: Data from five studies with common data elements were used in this secondary analysis. Samples from patients with fibromyalgia, sickle cell disease, cardiometabolic risk, pregnancy, and healthy controls were used. Reliability was estimated using Cronbach's alpha. Dimensionality was evaluated with confirmatory factor analysis. Concurrent validity was evaluated by examining Pearson's correlations between scores from the PROMIS F-SF, the Multidimensional Fatigue Symptom Inventory-Short Form, and the Brief Fatigue Inventory. Discriminant validity was evaluated by examining Pearson's correlations between scores on the PROMIS F-SF and measures of stress and depressive symptoms. Known groups validity was assessed by comparing PROMIS F-SF scores in the clinical samples to healthy controls.
   Results: Reliability of PROMIS F-SF scores was adequate across samples, ranging from .72 in the pregnancy sample to .88 in healthy controls. Unidimensionality was supported in each sample. Concurrent validity was strong; across the groups, correlations with scores on the Multidimensional Fatigue Symptom Inventory-Short Form and Brief Fatigue Inventory ranged from .60 to .85. Correlations of the PROMIS F-SF with measures of stress and depressive mood were moderate to strong, ranging from .37 to .64. PROMIS F-SF scores were significantly higher in clinical samples compared to healthy controls.
   Discussion: Reliability and validity of the PROMIS F-SF were acceptable. The PROMIS F-SF is a suitable measure of fatigue across the four diverse clinical populations included in the analysis.
C1 [Ameringer, Suzanne; Elswick, R. K., Jr.; Menzies, Victoria; Robins, Jo Lynne; Starkweather, Angela; Walter, Jeanne; Gentry, Amanda Elswick; Jallo, Nancy] Virginia Commonwealth Univ, Richmond, VA 23284 USA.
C3 Virginia Commonwealth University
RP Ameringer, S (corresponding author), Virginia Commonwealth Univ, Sch Nursing, 1100 East Leigh St, Richmond, VA 23298 USA.
EM swameringer@vcu.edu
RI Starkweather, Angela/HJP-5558-2023
OI Starkweather, Angela/0000-0001-7168-0144
FU National Institute of Health, Center of Excellence for Biobehavioral
   Approaches to Symptom Management [P30 NR011403]; National Institute of
   Nursing Research; CTSA Award from the National Center for Advancing
   Translational Sciences [UL1TR000058]
FX The authors acknowledge that this research was supported by a grant from
   the National Institute of Health, Center of Excellence for Biobehavioral
   Approaches to Symptom Management (M. J. Grap [PI], P30 NR011403
   2009-2014); National Institute of Nursing Research; and CTSA Award No.
   UL1TR000058 from the National Center for Advancing Translational
   Sciences.
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NR 69
TC 78
Z9 91
U1 0
U2 15
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0029-6562
EI 1538-9847
J9 NURS RES
JI Nurs. Res.
PD JUL-AUG
PY 2016
VL 65
IS 4
BP 279
EP 289
DI 10.1097/NNR.0000000000000162
PG 11
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA DQ8EG
UT WOS:000379441300004
PM 27362514
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Gu, YF
   Ye, XL
   Zhao, WT
   He, SW
   Zhang, WM
   Zeng, XY
AF Gu, Yunfan
   Ye, Xinglan
   Zhao, Wenting
   He, Shiwei
   Zhang, Weiming
   Zeng, Xianyu
TI The circadian syndrome is a better predictor for psoriasis than the
   metabolic syndrome via an explainable machine learning method - the
   NHANES survey during 2005-2006 and 2009-2014
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Article
DE metabolic syndrome; circadian syndrome; psoriasis; NHANES; machine
   learning; Mendelian randomization
ID WAIST CIRCUMFERENCE; WEIGHT CHANGE; RISK; DEPRESSION; OBESITY
AB Objective To explore the association between circadian syndrome (CircS) and Metabolic Syndrome (MetS) with psoriasis. Compare the performance of MetS and CircS in predicting psoriasis.Methods An observational study used data from the NHANES surveys conducted in 2005-2006 and 2009-2014. We constructed three multiple logistic regression models to investigate the relationship between MetS, CircS, and their components with psoriasis. The performance of MetS and CircS in predicting psoriasis was compared using five machine-learning algorithms, and the best-performing model was explained via SHAP. Then, bidirectional Mendelian randomization analyses with the inverse variance weighted (IVW) as the primary method were employed to determine the causal effects of each component.Result A total of 9,531 participants were eligible for the study. Both the MetS (OR = 1.53, 95%CI: 1.07-2.17, P = 0.02) and CircS (OR = 1.40, 95%CI: 1.02-1.91, P = 0.039) positively correlated with psoriasis. Each CircS algorithmic model performs better than MetS, with Categorical Features+Gradient Boosting for CircS (the area under the precision-recall curve = 0.969) having the best prediction effect on psoriasis. Among the components of CircS, elevated blood pressure, depression symptoms, elevated waist circumference (WC), and short sleep contributed more to predicting psoriasis. Under the IVW methods, there were significant causal relationships between WC (OR = 1.52, 95%CI: 1.34-1.73, P = 1.35e-10), hypertension (OR = 1.68, 95%CI: 1.19-2.37, P = 0.003), depression symptoms (OR = 1.39, 95%CI: 1.17-1.65, P = 1.51e-4), and short sleep (OR = 2.03, 95%CI: 1.21-3.39, p = 0.007) with psoriasis risk.Conclusion CircS demonstrated superior predictive ability for prevalent psoriasis compared to MetS, with elevated blood pressure, depression symptoms, and elevated WC contributing more to the prediction.
C1 [Gu, Yunfan; Zeng, Xianyu] Huazhong Univ Sci & Technol, Tradit Chinese & Western Med Hosp Wuhan, Tongji Med Coll, Dept Dermatol, Wuhan, Hubei, Peoples R China.
   [Gu, Yunfan] Nanjing Univ Chinese Med, Dept Dermatol, Suzhou Hosp Tradit Chinese Med, Suzhou, Peoples R China.
   [Ye, Xinglan; Zhang, Weiming] Hubei Univ Chinese Med, Sch Clin Tradit Chinese Med, Wuhan, Peoples R China.
   [Zhao, Wenting; He, Shiwei] Hubei Univ Chinese Med, Clin Coll 1, Wuhan, Peoples R China.
C3 Huazhong University of Science & Technology; Nanjing University of
   Chinese Medicine; Hubei University of Chinese Medicine; Hubei University
   of Chinese Medicine
RP Zeng, XY (corresponding author), Huazhong Univ Sci & Technol, Tradit Chinese & Western Med Hosp Wuhan, Tongji Med Coll, Dept Dermatol, Wuhan, Hubei, Peoples R China.; Zhang, WM (corresponding author), Hubei Univ Chinese Med, Sch Clin Tradit Chinese Med, Wuhan, Peoples R China.
EM drzhangweiming@163.com; whzengxianyu@163.com
RI Zhang, Weiming/KHY-6034-2024; Gu, Yunfan/ISU-3868-2023
FU Hubei TCM Administration 2023-2024 TCM Research Project [ZY2023Z012]
FX The author(s) declare financial support was received for the research,
   authorship, and/or publication of this article. This work was supported
   by Hubei TCM Administration 2023-2024 TCM Research Project (ZY2023Z012).
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NR 54
TC 2
Z9 2
U1 2
U2 11
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD JUN 26
PY 2024
VL 15
AR 1379130
DI 10.3389/fendo.2024.1379130
PG 13
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA YJ7L7
UT WOS:001268186600001
PM 38988999
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Alicka, M
   Marycz, K
AF Alicka, Michalina
   Marycz, Krzysztof
TI The Effect of Chronic Inflammation and Oxidative and Endoplasmic
   Reticulum Stress in the Course of Metabolic Syndrome and Its Therapy
SO STEM CELLS INTERNATIONAL
LA English
DT Review
ID MESENCHYMAL STEM-CELLS; UNFOLDED PROTEIN RESPONSE;
   NECROSIS-FACTOR-ALPHA; SUBCUTANEOUS ADIPOSE-TISSUE; 3RD NATIONAL-HEALTH;
   INSULIN-RESISTANCE; BONE-MARROW; ER STRESS; BETA-CELL; STROMAL CELLS
AB Metabolic syndrome (MetS) is highly associated with a modern lifestyle. The prevalence of MetS has reached epidemic proportion and is still rising. The main cause of MetS and finally type 2 diabetes occurrence is excessive nutrient intake, lack of physical activity, and inflammatory cytokines secretion. These factors lead to redistribution of body fat and oxidative and endoplasmic reticulum (ER) stress occurrence, resulting in insulin resistance, increase adipocyte differentiation, and much elevated levels of proinflammatory cytokines. Cellular therapies, especially mesenchymal stem cell (MSC) transplantation, seem to be promising in the MetS and type 2 diabetes treatments, due to their immunomodulatory effect and multipotent capacity; adipose-derived stem cells (ASCs) play a crucial role in MSC-based cellular therapies. In this review, we focused on etiopathology of MetS, especially on the crosstalk between chronic inflammation, oxidative stress, and ER stress and their effect on MetS-related disease occurrence, as well as future perspectives of cellular therapies. We also provide an overview of therapeutic approaches that target endoplasmic reticulum and oxidative stress.
C1 [Alicka, Michalina; Marycz, Krzysztof] Univ Environm & Life Sci Wroclaw, Fac Biol & Anim Sci, Dept Expt Biol, Wroclaw, Poland.
   [Marycz, Krzysztof] Justus Liebig Univ, Fac Vet Med, Equine Clin Equine Surg, D-35392 Giessen, Germany.
C3 Wroclaw University of Environmental & Life Sciences; Justus Liebig
   University Giessen
RP Marycz, K (corresponding author), Univ Environm & Life Sci Wroclaw, Fac Biol & Anim Sci, Dept Expt Biol, Wroclaw, Poland.; Marycz, K (corresponding author), Justus Liebig Univ, Fac Vet Med, Equine Clin Equine Surg, D-35392 Giessen, Germany.
EM krzysztof.marycz@upwr.edu.pl
RI Alicka, Michalina/AGZ-1134-2022
OI Alicka, Michalina/0000-0002-6717-9864
FU National Science Centre, Poland [2016/21/B/NZ7/01111]; Wroclaw Centre of
   Biotechnology programme the Leading National Research Centre (KNOW)
FX This research was supported by the National Science Centre, Poland,
   Grant no. 2016/21/B/NZ7/01111, "Modulation mitochondrial metabolism and
   dynamics and targeting DNA methylation of adipose derived mesenchymal
   stromal stem cell (ASC) using resveratrol and 5-azacytydine as a
   therapeutic strategy in the course of equine metabolic syndrome (EMS)."
   Publication was supported by the Wroclaw Centre of Biotechnology
   programme the Leading National Research Centre (KNOW) for years
   2014-2018.
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NR 149
TC 47
Z9 49
U1 0
U2 11
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1687-966X
EI 1687-9678
J9 STEM CELLS INT
JI Stem Cells Int.
PY 2018
VL 2018
AR 4274361
DI 10.1155/2018/4274361
PG 13
WC Cell & Tissue Engineering
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA GZ2ET
UT WOS:000449192000001
PM 30425746
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU González-Guardia, L
   Yubero-Serrano, EM
   Rangel-Zuñiga, O
   Marin, C
   Camargo, A
   Pérez-Martínez, P
   Delgado-Lista, J
   Gómez-Delgado, F
   Garcia-Rios, A
   Tinahones, FJ
   Roche, HM
   Pérez-Jiménez, F
   López-Miranda, J
AF Gonzalez-Guardia, Lorena
   Yubero-Serrano, Elena Maria
   Rangel-Zuniga, Oriol
   Marin, Carmen
   Camargo, Antonio
   Perez-Martinez, Pablo
   Delgado-Lista, Javier
   Gomez-Delgado, Francisco
   Garcia-Rios, Antonio
   Jose Tinahones, Francisco
   Roche, Helen M.
   Perez-Jimenez, Francisco
   Lopez-Miranda, Jose
TI Influence of endothelial dysfunction on telomere length in subjects with
   metabolic syndrome: LIPGENE study
SO AGE
LA English
DT Article
DE Endothelial dysfunction; LIPGENE study; Metabolic syndrome; Oxidative
   stress; Telomeres
ID OXIDATIVE STRESS; INSULIN-RESISTANCE; QUANTITATIVE PCR; CELLS;
   F-2-ISOPROSTANES; ACCUMULATION; SENSITIVITY; ATTRITION; DISEASE; STATE
AB Previous evidences support that increased oxidative stress (OxS) may play an important role in metabolic syndrome (MetS) and both are closely linked to vascular dysfunction. This study determined whether there is a relationship between endothelial function and relative telomere length (RTL) in MetS subjects. In this cross-sectional study from the LIPGENE cohort, a total of 88 subjects (36 men and 52 women) were divided into four groups by quartiles of telomere length. We measured ischemic reactive hyperemia (IRH), total nitrite (NO) and protein carbonyl (PC) plasma levels, F2-isoprostanes urinary levels, and superoxide dismutase (SOD) and glutathione peroxidase (GPx) plasma activities. IRH and NO plasma levels were higher in subjects with longer RTL (quartiles 3 and 4), while PC plasma levels, F2-isoprostanes urinary levels, and GPx and SOD plasma activities were lower in quartile 4 subjects (longest RTL). Additionally, MetS subjects with longer RTL had greater homeostatic model assessment-beta level and lower triglycerides plasma levels. Our results suggest that endothelial dysfunction, associated with high levels of OxS, could be entailed in an increment of telomere attrition. Thus, further support of the molecular and cellular mechanisms involved in vascular dysfunction may contribute to the development of strategies to decelerate vascular aging or prevent cardiovascular disease.
C1 [Gonzalez-Guardia, Lorena; Rangel-Zuniga, Oriol; Marin, Carmen; Camargo, Antonio; Perez-Martinez, Pablo; Delgado-Lista, Javier; Gomez-Delgado, Francisco; Garcia-Rios, Antonio; Perez-Jimenez, Francisco; Lopez-Miranda, Jose] Univ Cordoba, Reina Sofia Univ Hosp, IMIBIC, Lipids & Atherosclerosis Unit, E-14004 Cordoba, Spain.
   [Gonzalez-Guardia, Lorena; Rangel-Zuniga, Oriol; Marin, Carmen; Camargo, Antonio; Perez-Martinez, Pablo; Gomez-Delgado, Francisco; Garcia-Rios, Antonio; Jose Tinahones, Francisco; Perez-Jimenez, Francisco; Lopez-Miranda, Jose] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr CIBEROBN, Madrid, Spain.
   [Yubero-Serrano, Elena Maria] Mt Sinai Sch Med, Dept Geriatr & Palliat Care, Div Expt Diabet & Aging, New York, NY USA.
   [Jose Tinahones, Francisco] Hosp Virgen de la Victoria, Dept Endocrinol, Biomed Res Lab, Malaga, Spain.
   [Roche, Helen M.] Univ Coll Dublin, UCD Conway Inst, Nutrigen Res Grp, Sch Publ Hlth & Populat Sci, Dublin 2, Ireland.
C3 Universidad de Cordoba; Hospital Universitario Reina Sofia - Cordoba;
   CIBER - Centro de Investigacion Biomedica en Red; CIBEROBN; Instituto de
   Salud Carlos III; Icahn School of Medicine at Mount Sinai; University
   College Dublin
RP López-Miranda, J (corresponding author), Univ Cordoba, Reina Sofia Univ Hosp, IMIBIC, Lipids & Atherosclerosis Unit, Avda Menendez Pidal S-N, E-14004 Cordoba, Spain.
EM jlopezmir@uco.es
RI Roche, Helen/AAF-4164-2019; Tinahones, Francisco/AAB-2882-2020;
   Delgado-Lista, Javier/KAM-7412-2024; Lopez-Miranda, Jose/Y-8306-2019;
   Yubero-Serrano, Elena/H-4832-2013; Jimenez, Francisco/AAJ-9559-2021;
   Tejada, Silvia/L-7297-2014; Marin Hinojosa, Carmen/AFO-1294-2022;
   Camargo Garcia, Antonio/G-9720-2015; Gomez Delgado,
   Francisco/H-4552-2015; Perez Martinez, Pablo/AEL-6176-2022
OI Perez Jimenez, Francisco/0000-0001-9808-1280; Tinahones, Francisco
   J/0000-0001-6871-4403; Rangel-Zuniga, Oriol Alberto/0000-0003-3495-5705;
   Perez-Jimenez, Francisco/0000-0001-7499-7681; Camargo Garcia,
   Antonio/0000-0002-0415-4184; Gomez Delgado,
   Francisco/0000-0002-0216-2084; Delgado Lista, Francisco
   Javier/0000-0002-2982-2716; Yubero-Serrano, Elena M/0000-0002-2733-5359;
   Lopez-Miranda, Jose/0000-0002-8844-0718; Perez Martinez,
   Pablo/0000-0001-7716-8117; Roche, Helen/0000-0002-0628-3318
FU Ministerio de Ciencia e Innovacion [AGL2006-01979, AGL2009-12270];
   'Fisiopatologia de la Obesidad y Nutricion' is an ISCIII
   [CB06/03/0047-CIBER]; Consejeria de Innovacion; Ciencia y Empresa; Junta
   de Andalucia [P06-CTS-01425, CVI-7450]; Consejeria de Salud, Junta de
   Andalucia [06/128, 07/43, PI0193/2009, 06/129]
FX This research was supported partly by grants from the Ministerio de
   Ciencia e Innovacion (AGL2006-01979, AGL2009-12270 to JL-M),
   ('CB06/03/0047-CIBER Fisiopatologia de la Obesidad y Nutricion' is an
   ISCIII grant awarded to FP-J), Consejeria de Innovacion, Ciencia y
   Empresa, Junta de Andalucia (P06-CTS-01425 and CVI-7450 to JL-M), and
   Consejeria de Salud, Junta de Andalucia (06/128, 07/43, PI0193/2009 to
   JL-M, 06/129 to FP-J).
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NR 44
TC 14
Z9 15
U1 1
U2 11
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0161-9152
EI 1574-4647
J9 AGE
JI Age
PD AUG
PY 2014
VL 36
IS 4
AR 9681
DI 10.1007/s11357-014-9681-9
PG 9
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA AR8BR
UT WOS:000343801100018
PM 25012274
OA Green Published
DA 2025-06-11
ER

PT J
AU Ravibabu, K
   Jakkam, S
   Prakash, JR
   Adepu, VK
AF Ravibabu, Kalahasthi
   Jakkam, Surender
   Prakash, Jamalpur Ravi
   Adepu, Vinay Kumar
TI Association of industrial work schedules with development of metabolic
   syndrome, insulin resistance, and serum adipokine concentrations
SO ASIAN BIOMEDICINE
LA English
DT Article
DE metabolic syndrome; insulin resistance; adipokines; shift work schedule;
   occupational health
ID NIGHT-SHIFT WORK; OXIDATIVE STRESS; GLUCOSE; RISK; ADIPONECTIN;
   PREVALENCE; SECRETION; EMPLOYEES; MARKERS; OBESITY
AB Background: Association of work schedule in industrial workers with the progression of metabolic syndrome, insulin resistance, and serum adipokine concentrations is incompletely explored.
   Objective To determine the association of work schedule with the progression of metabolic syndrome, insulin resistance, and adipokine concentrations in industrial workers.
   Methods: In a cross-sectional study design of industrial workers we compared metabolic syndrome, insulin resistance, and adipokines concentration between workers in the day shift (n = 52), rotational shift (n = 21), and night shift (n = 15). The international Diabetes Federation criteria were used to diagnose metabolic syndrome. We used a homeostatic model assessment of insulin resistance (HOMA-IR). Serum insulin, leptin, and adiponectin concentrations were measured using enzyme-linked immunosorbent assays. Serum glucose, triglyceride, and high-density lipoprotein cholesterol (HDL-C) concentrations were monitored using Prietest clinical chemistry reagents.
   Results: The proportional difference in metabolic syndrome (0.31, 95% confidence interval [CI] 0.036-0.587, P = 0.026), median difference of leptin (0.61, 95% CI 0.186-1.034, P = 0.005), and leptin-to-adiponectin ratio (LAR; 0.45, 95% CI 0.235-0.665, P < 0.001) was significantly higher, and serum adiponectin was lower (-2.00, 95% CI -4.197 to 0.197, P = 0.07) in the night-shift workers compared with that of day-shift workers. Among rotational-shift workers, the proportional difference between metabolic syndrome (0.14, 95% CI -0.098 to 0.378, P = 0.25), median difference of leptin (0.25, 95% CI -0.124 to 0.624, P = 0.19), and LAR (0.09, 95% CI -0.099 to 0.279, P = 0.35) was higher, and serum adiponectin concentration was lower (-0.73, 95% CI -2.660 to 1.208, P = 0.46) compared with that of day-shift workers; however, the altered differences were not significant. We observed a higher proportion of difference in HOMA-IR in shift workers (night and rotation) than in day-shift workers.
   Conclusion: Night-shift workers are vulnerable to a higher risk of metabolic syndrome, HOMA-IR, and adipokine changes.
C1 [Ravibabu, Kalahasthi; Jakkam, Surender; Prakash, Jamalpur Ravi; Adepu, Vinay Kumar] Indian Council Med Res, Reg Occupat Hlth Ctr Southern, Dept Biochem, ICMR Complex,Kannamangala Post,Poojanahalli Rd, Bengaluru 562110, Karnataka, India.
C3 Indian Council of Medical Research (ICMR); ICMR - National Institute of
   Occupational Health (NIOH)
RP Ravibabu, K (corresponding author), Indian Council Med Res, Reg Occupat Hlth Ctr Southern, Dept Biochem, ICMR Complex,Kannamangala Post,Poojanahalli Rd, Bengaluru 562110, Karnataka, India.
EM ravibabu.k@gov.in
FU Indian Council for Medical Research; National -Institute of Occupational
   Health
FX Funding for this study was provided by the Indian Council for Medical
   Research and the National -Institute of Occupational Health.
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NR 55
TC 1
Z9 1
U1 0
U2 3
PU WALTER DE GRUYTER GMBH
PI BERLIN
PA GENTHINER STRASSE 13, D-10785 BERLIN, GERMANY
SN 1905-7415
EI 1875-855X
J9 ASIAN BIOMED
JI Asian Biomed.
PD APR
PY 2021
VL 15
IS 2
BP 69
EP 77
DI 10.2478/abm-2021-0009
PG 9
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA ST9UK
UT WOS:000662785400003
PM 37551404
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Son, SM
   Park, EJ
   Cho, YH
   Lee, SY
   Choi, JI
   Lee, YI
   Kim, YJ
   Lee, JG
   Yi, YH
   Tak, YJ
   Hwang, HR
   Lee, SH
   Kwon, RJ
   Kim, C
AF Son, Soo Min
   Park, Eun-Ju
   Cho, Young Hye
   Lee, Sang Yeoup
   Choi, Jung-In
   Lee, Young-In
   Kim, Yun Jin
   Lee, Jeong Gyu
   Yi, Yu Hyeon
   Tak, Young Jin
   Hwang, Hye Rim
   Lee, Seung-Hun
   Kwon, Ryuk Jun
   Kim, Choongrak
TI Association Between Weekend Catch-Up Sleep and Metabolic Syndrome with
   Sleep Restriction in Korean Adults: A Cross-Sectional Study Using
   KNHANES
SO DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
LA English
DT Article
DE sleep recovery; sleep deprivation; metabolic syndrome; insulin
   sensitivity
ID OXIDATIVE STRESS; NERVOUS-SYSTEM; SOCIAL JETLAG; DURATION; RISK;
   METAANALYSIS; HYPERTENSION; PREVALENCE; OVERWEIGHT; MORTALITY
AB Background: Many researchers have identified that adequate sleep duration is linked to the quality of life and metabolic diseases. Nowadays, it is hard to take enough sleep, so weekend catch-up sleep (CUS) may be an alternative option in modern society. To our knowledge, no previous studies reported the association between weekend CUS and metabolic syndrome, especially in the Korean population.
   Objective: We investigated the association between weekend CUS and the prevalence of metabolic syndrome in Korean adults (>= 20 years old) with less than 6 hours of average weekday sleep.
   Patients and Methods: A total of 1,453 individuals were selected from the Korean National Health and Nutrition Examination Survey. Weekend CUS was divided into four categories: <= 0 hour, 0-1 hour, 1-2 hours, and >= 2 hours. Odds ratios (ORs) with 95% confidence intervals (CIs) were derived by univariate and multivariate logistic regression analyses.
   Results: Participants with weekend CUS >= 1 hour had decreased risk of metabolic syndrome in univariate analysis (CUS 1-2 hours: OR: 0.413, 95% CI: 0.301-0.568; CUS >= 2 hours: OR: 0.382, 95% CI 0.296-0.493). Weekend CUS 1-2 hours reduced the risk of metabolic syndrome in multivariate logistic regression analysis (OR: 0.552, 95% CI: 0.369-0.823). Based on the age group analysis, weekend CUS >= 1 hour reduced the metabolic syndrome among those aged 20-39 and 40-65 (20-39: CUS 1-2 hours OR: 0.248, 95% CI: 0.078-0.783, CUS >= 2 hours OR: 0.374, 95% CI: 0.141-0.991; 40-65: CUS 1-2 hours OR: 0.507, 95% CI 0.309-0.832 CUS >= 2 hours OR: 0.638, 95% CI: 0.415-0.981).
   Conclusion: Weekend CUS was associated with a low risk of metabolic syndrome among Korean adults with sleep restriction.
C1 [Son, Soo Min; Park, Eun-Ju; Cho, Young Hye; Lee, Sang Yeoup; Choi, Jung-In; Lee, Young-In; Kwon, Ryuk Jun] Pusan Natl Univ, Family Med Clin, Yangsan Hosp, Yangsan 50612, Gyeongsangnam D, South Korea.
   [Son, Soo Min; Park, Eun-Ju; Cho, Young Hye; Lee, Sang Yeoup; Choi, Jung-In; Lee, Young-In; Kwon, Ryuk Jun] Pusan Natl Univ, Res Inst Convergence Biomed Sci & Technol, Yangsan Hosp, Yangsan 50612, Gyeongsangnam D, South Korea.
   [Kim, Yun Jin; Lee, Jeong Gyu; Yi, Yu Hyeon; Tak, Young Jin; Hwang, Hye Rim; Lee, Seung-Hun] Pusan Natl Univ Hosp, Dept Family Med, Busan 626770, South Korea.
   [Kim, Yun Jin; Lee, Jeong Gyu; Yi, Yu Hyeon; Tak, Young Jin; Hwang, Hye Rim; Lee, Seung-Hun] Pusan Natl Univ Hosp, Biomed Res Inst, Busan 626770, South Korea.
   [Kim, Choongrak] Pusan Natl Univ, Dept Stat, Busan 609735, South Korea.
C3 Pusan National University; Pusan National University Hospital; Pusan
   National University; Pusan National University Hospital; Pusan National
   University; Pusan National University Hospital; Pusan National
   University; Pusan National University Hospital; Pusan National
   University
RP Park, EJ (corresponding author), Pusan Natl Univ, Dept Internal Med, Med Family Med, Yangsan Hosp, Yangsan 50612, South Korea.
EM everblue124@hanmail.net
RI Park, Eunju/AAC-5266-2021; LEE, SUN HEE/AAB-5714-2022; Cho, Young
   Hye/AEJ-4099-2022; Kisa, Adnan/Q-2081-2019; Lee, Sang
   Yeoup/IZE-0083-2023
OI Park, Eun Ju/0000-0003-2415-8243; Choi, Jung In/0000-0003-3832-3393;
   Son, Soo Min/0000-0002-0165-7480; Lee, Sang Yeoup/0000-0002-3585-9910
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NR 32
TC 25
Z9 25
U1 2
U2 8
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-7007
J9 DIABET METAB SYND OB
JI Diabetes Metab. Syndr. Obes.
PY 2020
VL 13
BP 1465
EP 1471
DI 10.2147/DMSO.S247898
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA LK2QI
UT WOS:000530705500001
PM 32431530
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Ghitea, TC
   Aleya, L
   Tit, DM
   Behl, T
   Stoicescu, M
   Sava, C
   Iovan, C
   El-Kharoubi, A
   Uivarosan, D
   Pallag, A
   Bungau, S
AF Ghitea, Timea Claudia
   Aleya, Lotfi
   Tit, Delia Mirela
   Behl, Tapan
   Stoicescu, Manuela
   Sava, Cristian
   Iovan, Ciprian
   El-Kharoubi, Amina
   Uivarosan, Diana
   Pallag, Annamaria
   Bungau, Simona
TI Influence of diet and sport on the risk of sleep apnea in patients with
   metabolic syndrome associated with hypothyroidism - a 4-year survey
SO ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
LA English
DT Article
DE Obstructive sleep apnea; Hypothyroidism; Diet therapy; Stress; Sports;
   Metabolic syndrome
ID INSULIN-RESISTANCE; OXIDATIVE STRESS; QUESTIONNAIRE; PREVALENCE; OBESITY
AB Apnea is a common problem observed among obese individuals, affecting the quality of sleep and increasing cardiovascular risk and mortality. The current study monitored the risk of obstructive sleep apnea (OSA) following diet therapy and sports-associated diet therapy in patients with metabolic syndrome (MS) and hypothyroidism. The subjects included in the study were divided into 3 groups: control group (CG) (n=36), diet therapy group (DG) (including patients following a personalized diet therapy program) (n=76), and diet therapy and sports group (DSG) (which considered patients doing sports in addition to following a personalized diet therapy program) (n=80). The evaluation methods included body analysis (body mass index, fat mass, and visceral fat), paraclinical analysis (homeostasis model assessment of insulin resistance), assessment of difficulty in breathing, stress monitoring, hypothyroidism, and risk of OSA. The OSA index was assessed using the Berlin Questionnaire of Sleep Apnea and Epworth Sleepiness Scale. The correlation between OSA with body mass index (BMI), homeostasis model assessment of insulin resistance (HOMA-IR) index, fat mass, and visceral fat showed a statistically significant positive ratio (pF=3.871). The obtained results indicated that diet therapy and physical activity reduced the OSA risk by 78.72%.
C1 [Ghitea, Timea Claudia; Tit, Delia Mirela; Pallag, Annamaria; Bungau, Simona] Univ Oradea, Fac Med & Pharm, Dept Pharm, Oradea 410028, Romania.
   [Aleya, Lotfi] Univ Franche Comte, CNRS 6249, Lab Chronoenvironm, Besancon, France.
   [Tit, Delia Mirela; Pallag, Annamaria; Bungau, Simona] Univ Oradea, Doctoral Sch Biol & Biomed Sci, Oradea 410073, Romania.
   [Behl, Tapan] Chitkara Univ, Chitkara Coll Pharm, Dept Pharmacol, Rajpura 140401, Punjab, India.
   [Stoicescu, Manuela; Sava, Cristian; El-Kharoubi, Amina] Univ Oradea, Fac Med & Pharm, Dept Med Disciplines, Oradea 410073, Romania.
   [Iovan, Ciprian; Uivarosan, Diana] Univ Oradea, Fac Med & Pharm, Dept Preclin Disciplines, Oradea 410068, Romania.
C3 University of Oradea; Universite de Franche-Comte; University of Oradea;
   Chitkara University, Punjab; University of Oradea; University of Oradea
RP Bungau, S (corresponding author), Univ Oradea, Fac Med & Pharm, Dept Pharm, Oradea 410028, Romania.; Aleya, L (corresponding author), Univ Franche Comte, CNRS 6249, Lab Chronoenvironm, Besancon, France.; Bungau, S (corresponding author), Univ Oradea, Doctoral Sch Biol & Biomed Sci, Oradea 410073, Romania.
EM timea.ghitea@csud.uoradea.ro; lotfi.aleya@univ-fcomte.fr;
   mirela_tit@yahoo.com; tapanbehl31@gmail.com;
   manuela_stoicescu@yahoo.com; cristian.sava2004@gmail.com;
   dr.iovan@biostandard.ro; aminaadnan2005@yahoo.com;
   diana.uivarosan@gmail.com; annamariapallag@gmail.com;
   simonabungau@gmail.com
RI Uivarosan, Diana/AAT-6035-2020; Bungau, Simona Gabriela/C-1831-2015;
   Venter, Amina/KHE-3962-2024; Pallag, Annamaria/AAQ-4091-2020; Tit,
   Delia/AAT-5032-2020; Stoicescu, Manuela/AAC-9008-2022; SAVA,
   CRISTIAN/AAB-3865-2020; Ghitea, Timea Claudia/AAJ-4273-2021
OI Ghitea, Timea Claudia/0000-0001-8981-1958; Sava,
   Cristian/0000-0001-6456-5770; /0000-0003-3236-1292
CR [Anonymous], 2018, WORLD MEDICAL ASS
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NR 50
TC 12
Z9 12
U1 3
U2 19
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0944-1344
EI 1614-7499
J9 ENVIRON SCI POLLUT R
JI Environ. Sci. Pollut. Res.
PD APR
PY 2022
VL 29
IS 16
BP 23158
EP 23168
DI 10.1007/s11356-021-17589-x
EA NOV 2021
PG 11
WC Environmental Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology
GA 0H8WJ
UT WOS:000720706400013
PM 34802081
DA 2025-06-11
ER

PT J
AU Zhou, KB
   Kumar, U
   Yuen, VG
   McNeill, JH
AF Zhou, Kangbin
   Kumar, Ujendra
   Yuen, Violet G.
   McNeill, John H.
TI The effects of phentolamine on fructose-fed rats
SO CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
LA English
DT Article
DE metabolic syndrome; elevated blood pressure; adrenaline; angiotensin II;
   oxidative stress; uric acid
ID INDUCED INSULIN-RESISTANCE; CONVERTING ENZYME-INHIBITOR; NITRIC-OXIDE
   SYNTHASE; METABOLIC-SYNDROME; OXIDATIVE STRESS; ANGIOTENSIN-II;
   BLOOD-PRESSURE; VASCULAR DYSFUNCTION; INDUCED HYPERTENSION;
   RENIN-ANGIOTENSIN
AB Metabolic syndrome (MS) is a combination of medical disorders that increase the risk of developing cardiovascular disease and diabetes. MS is associated with obesity, increased blood pressure, hyperlipidemia, and hyperglycemia. This study was designed to investigate the pharmacological profile of phentolamine, a nonselective a adrenergic receptor antagonist, in the prevention of increased blood pressure in fructose-fed rats. Phentolamine prevented the fructose-induced increase in systolic blood pressure without affecting insulin sensitivity and major metabolic parameters. The levels of plasma noradrenaline and angiotensin II, 2 proposed contributors to the development of fructose-induced elevated blood pressure, were examined. Neither noradrenaline nor angiotensin II levels were affected by phentolamine treatment. Since overproduction of nitric oxide has been shown to lead to an elevation in peroxynitrite, the role of oxidative stress, a proposed mechanism of fructose-induced elevated blood pressure and insulin resistance, was examined by measuring plasma levels of total nitrate/nitrite. Plasma nitrate/nitrite was significantly elevated in all fructose-fed animals, regardless of treatment with phentolamine. Another proposed contributor toward fructose-induced MS is an elevation in uric acid levels. In this experiment, plasma levels of uric acid were found to be increased by dietary fructose and were unaffected by phentolamine treatment.
C1 [Zhou, Kangbin; Kumar, Ujendra; Yuen, Violet G.; McNeill, John H.] Univ British Columbia, Fac Pharmaceut Sci, Vancouver, BC V6T 1Z3, Canada.
C3 University of British Columbia
RP McNeill, JH (corresponding author), Univ British Columbia, Fac Pharmaceut Sci, 2146 East Mall, Vancouver, BC V6T 1Z3, Canada.
EM jmcneill@mail.ubc.ca
FU Canadian Institutes for Health Research
FX This project was supported by the Canadian Institutes for Health
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NR 90
TC 4
Z9 5
U1 0
U2 2
PU CANADIAN SCIENCE PUBLISHING
PI OTTAWA
PA 65 AURIGA DR, SUITE 203, OTTAWA, ON K2E 7W6, CANADA
SN 0008-4212
EI 1205-7541
J9 CAN J PHYSIOL PHARM
JI Can. J. Physiol. Pharmacol.
PD AUG
PY 2012
VL 90
IS 8
BP 1075
EP 1085
DI 10.1139/Y2012-063
PG 11
WC Pharmacology & Pharmacy; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Physiology
GA 977XI
UT WOS:000306697800012
PM 22783820
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Pakdeechote, P
   Bunbupha, S
   Kukongviriyapan, U
   Prachaney, P
   Khrisanapant, W
   Kukongviriyapan, V
AF Pakdeechote, Poungrat
   Bunbupha, Sarawoot
   Kukongviriyapan, Upa
   Prachaney, Parichat
   Khrisanapant, Wilaiwan
   Kukongviriyapan, Veerapol
TI Asiatic Acid Alleviates Hemodynamic and Metabolic Alterations via
   Restoring eNOS/iNOS Expression, Oxidative Stress, and Inflammation in
   Diet-Induced Metabolic Syndrome Rats
SO NUTRIENTS
LA English
DT Article
DE metabolic syndrome; asiatic acid; inflammation; oxidative stress
ID INDUCED DIABETIC-RATS; HIGH-FAT; HIGH-CARBOHYDRATE; INSULIN-RESISTANCE;
   LIVER CHANGES; WEIGHT-LOSS; OBESITY; HYPERTENSION; ANTIOXIDANT;
   DYSFUNCTION
AB Asiatic acid is a triterpenoid isolated from Centella asiatica. The present study aimed to investigate whether asiatic acid could lessen the metabolic, cardiovascular complications in rats with metabolic syndrome (MS) induced by a high-carbohydrate, high-fat (HCHF) diet. Male Sprague-Dawley rats were fed with HCHF diet with 15% fructose in drinking water for 12 weeks to induce MS. MS rats were treated with asiatic acid (10 or 20 mg/kg/day) or vehicle for a further three weeks. MS rats had an impairment of oral glucose tolerance, increases in fasting blood glucose, serum insulin, total cholesterol, triglycerides, mean arterial blood pressure, heart rate, and hindlimb vascular resistance; these were related to the augmentation of vascular superoxide anion production, plasma malondialdehyde and tumor necrosis factor-alpha (TNF-alpha) levels (p < 0.05). Plasma nitrate and nitrite (NOx) were markedly high with upregulation of inducible nitric oxide synthase (iNOS) expression, but dowregulation of endothelial nitric oxide synthase (eNOS) expression (p < 0.05). Asiatic acid significantly improved insulin sensitivity, lipid profiles, hemodynamic parameters, oxidative stress markers, plasma TNF-alpha, NOx, and recovered abnormality of eNOS/iNOS expressions in MS rats (p < 0.05). In conclusion,
C1 [Pakdeechote, Poungrat; Bunbupha, Sarawoot; Kukongviriyapan, Upa; Khrisanapant, Wilaiwan] Khon Kaen Univ, Dept Physiol, Fac Med, Khon Kaen 40002, Thailand.
   [Prachaney, Parichat] Khon Kaen Univ, Dept Anat, Fac Med, Khon Kaen 40002, Thailand.
   [Kukongviriyapan, Veerapol] Khon Kaen Univ, Dept Pharmacol, Fac Med, Khon Kaen 40002, Thailand.
C3 Khon Kaen University; Khon Kaen University; Khon Kaen University
RP Pakdeechote, P (corresponding author), Khon Kaen Univ, Dept Physiol, Fac Med, Khon Kaen 40002, Thailand.
EM ppoung@kku.ac.th; bugvo@hotmail.com; upa_ku@kku.ac.th; parpra@kku.ac.th;
   wilkhr@kku.ac.th; veerapol@kku.ac.th
FU Thailand Research Fund [MRG5580001]; Invitation Research Fund (Faculty
   of Medicine, Khon Kaen University), Khon Kaen University; Graduate
   School, Khon Kaen University, Thailand
FX This work was supported by grants from the Thailand Research Fund
   (MRG5580001), the Invitation Research Fund (Faculty of Medicine, Khon
   Kaen University), Khon Kaen University under Incubation Researcher
   Project. Sarawoot Bunbupha holds a scholarship from Graduate School,
   Khon Kaen University, Thailand.
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NR 43
TC 88
Z9 96
U1 0
U2 48
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JAN
PY 2014
VL 6
IS 1
BP 355
EP 370
DI 10.3390/nu6010355
PG 16
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA AF7RX
UT WOS:000334913400022
PM 24441717
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Quetglas-Llabrés, MM
   Monserrat-Mesquida, M
   Bouzas, C
   Gómez, C
   Mateos, D
   Ripoll-Vera, T
   Tur, JA
   Sureda, A
AF Magdalena Quetglas-Llabres, Maria
   Monserrat-Mesquida, Margalida
   Bouzas, Cristina
   Gomez, Cristina
   Mateos, David
   Ripoll-Vera, Tomas
   Tur, Josep A.
   Sureda, Antoni
TI Inflammatory and Oxidative Stress Markers Related to Adherence to the
   Mediterranean Diet in Patients with Metabolic Syndrome
SO ANTIOXIDANTS
LA English
DT Article
DE metabolic syndrome; cardiovascular risk; Mediterranean diet; oxidative
   stress; inflammation
ID EXPRESSION; GHRELIN; ANTIOXIDANTS; DEFINITION; RESISTIN; OBESITY;
   LEPTIN; ADULTS; RISK; MEN
AB Metabolic syndrome (MetS) is characterized by increased pro-oxidative stress and a pro-inflammatory state. Several studies emphasized the protective effect of the Mediterranean dietary pattern (MDP). To assess the oxidative and inflammatory state according to the adherence to MDP using biomarkers in patients with MetS. Antioxidant and pro-inflammatory biomarkers were determined in plasma, peripheral blood mononuclear cells (PBMCs), and neutrophils of adults (aged 55-75 years old; 60% women) with MetS living in Mallorca (Spain). Anthropometrics, dietary intake by a validated semi-quantitative 143-item food frequency questionnaire, and a Dietary Inflammatory Index were measured. Patients with low adherence to MDP showed higher levels of glycated haemoglobin A1c and triglycerides, and lower levels of HDL cholesterol. Plasma levels of interleukin-1 beta, IL-6, IL-15, tumour necrosis factor alpha, xanthine oxidase, and ghrelin, and activities of superoxide dismutase, and myeloperoxidase were higher in subjects with low adherence to the MDP. Reactive oxygen species production in PBMCs and neutrophils stimulated with lipopolysaccharide was higher in participants with low adherence to the MDP. Patients with MetS and higher adherence to the MDP showed less altered anthropometric parameters, blood biochemical profile, and better oxidative and inflammatory status.
C1 [Magdalena Quetglas-Llabres, Maria; Monserrat-Mesquida, Margalida; Bouzas, Cristina; Gomez, Cristina; Mateos, David; Ripoll-Vera, Tomas; Tur, Josep A.; Sureda, Antoni] Univ Balearic Isl IUNICS, Res Grp Community Nutr & Oxidat Stress, Palma De Mallorca 07122, Spain.
   [Magdalena Quetglas-Llabres, Maria; Monserrat-Mesquida, Margalida; Bouzas, Cristina; Gomez, Cristina; Mateos, David; Ripoll-Vera, Tomas; Tur, Josep A.; Sureda, Antoni] Hlth Res Inst Balearic Isl IdISBa, Palma De Mallorca 07120, Spain.
   [Monserrat-Mesquida, Margalida; Bouzas, Cristina; Ripoll-Vera, Tomas; Tur, Josep A.; Sureda, Antoni] Inst Salud Carlos III ISCIII, CIBER Fisiopatol Obesidad & Nutr CIBEROBN, Madrid 28029, Spain.
   [Gomez, Cristina] Univ Hosp Son Espases, Clin Anal Serv, Palma De Mallorca 07198, Spain.
   [Ripoll-Vera, Tomas] Univ Hosp Son Llatzer, Cardiol Serv, Palma De Mallorca 07010, Spain.
C3 Institut Investigacio Sanitaria Illes Balears (IdISBa); CIBER - Centro
   de Investigacion Biomedica en Red; CIBEROBN; Hospital Universitari Son
   Espases; Hospital Universitari Son Llatzer
RP Tur, JA (corresponding author), Univ Balearic Isl IUNICS, Res Grp Community Nutr & Oxidat Stress, Palma De Mallorca 07122, Spain.; Tur, JA (corresponding author), Hlth Res Inst Balearic Isl IdISBa, Palma De Mallorca 07120, Spain.; Tur, JA (corresponding author), Inst Salud Carlos III ISCIII, CIBER Fisiopatol Obesidad & Nutr CIBEROBN, Madrid 28029, Spain.
EM m.quetglas@uib.es; margalida.monserrat@uib.es; cristina.bouzas@uib.es;
   cristina.gomez@ssib.es; davidfrom13@gmail.com; tripoll@hsll.es;
   pep.tur@uib.es; antoni.sureda@uib.es
RI Sureda, Antoni/N-9588-2019; Ripoll-Vera, Tomas/AAT-3535-2021; Bouzas,
   Cristina/AAE-2069-2019; Quetglas Llabrés, Maria/AAA-4412-2019; Mesquida,
   Margalida/AAB-4773-2019; Mateos, David/N-7366-2018; Tur,
   Josep/AAE-5748-2020; Tur, Josep/F-5576-2014
OI Tur, Josep/0000-0002-6940-0761; Monserrat Mesquida,
   Margalida/0000-0002-8856-135X; , Antoni/0000-0001-8656-6838; Bouzas
   Velasco, Cristina/0000-0002-1407-8461; RIPOLL-VERA,
   TOMAS/0000-0001-9222-325X; GOMEZ COBO, CRISTINA/0000-0002-9776-4730
FU Instituto de Salud Carlos III through the Fondo de Investigacion para la
   Salud [CB12/03/30038, OBN18PI03, PI20/00456]; European Regional
   Development Fund; IDISBA
FX Instituto de Salud Carlos III through the Fondo de Investigacion para la
   Salud (CIBEROBN CB12/03/30038, Proyecto Intramural CIBER OBN18PI03, and
   project PI20/00456), which are co-funded by the European Regional
   Development Fund. IDISBA Grants (FOLIUM, PRIMUS, SYNERGIA, and LIBERI).
   M.Q.-L.L. was granted by IDISBA grant. The funding sponsors had no role
   in the design of the study, in the collection, analysis, or
   interpretation of the data; in the writing of the manuscript, or in the
   decision to publish the results.
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NR 72
TC 24
Z9 25
U1 1
U2 11
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD MAY
PY 2022
VL 11
IS 5
AR 901
DI 10.3390/antiox11050901
PG 16
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA 1P3GY
UT WOS:000801902700001
PM 35624765
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Arias-Chávez, DJ
   Mailloux-Salinas, P
   Altamirano, J
   Huang, FY
   Gómez-Viquez, NL
   Bravo, G
AF Julian Arias-Chavez, David
   Mailloux-Salinas, Patrick
   Altamirano, Julio
   Huang, Fengyang
   Leticia Gomez-Viquez, Norma
   Bravo, Guadalupe
TI Consumption of combined fructose and sucrose diet exacerbates oxidative
   stress, hypertrophy and CaMKIIδ oxidation in hearts from rats
   with metabolic syndrome
SO MOLECULAR AND CELLULAR BIOCHEMISTRY
LA English
DT Article
DE Metabolic syndrome; Cardiac hypertrophy; Oxidative stress; CaMKII delta
   high sucrose diet; High fructose diet
ID HYPERTENSION; ACTIVATION; PATHWAYS; SYSTEM
AB The prevalence of the metabolic syndrome (MetS) and its cardiac comorbidities as cardiac hypertrophy (CH) have increased considerably due to the high consumption of carbohydrates, such as sucrose and/or fructose. We compared the effects of sucrose (S), fructose (F) and their combination (S + F) on the development of MetS in weaned male Wistar rats and established the relationship between the consumption of these sugars and the degree of cardiac CH development, oxidative stress (OS) and Calcium/calmodulin-dependent protein kinase type II subunit delta oxidation (ox-CaMKII delta). 12 weeks after the beginning of treatments with S, F or S + F, arterial pressure was measured and 8 weeks later (to complete 20 weeks) the animals were sacrificed and blood samples, visceral adipose tissue and hearts were obtained. Biochemical parameters were determined in serum and cardiac tissue to evaluate the development of MetS and OS. To evaluate CH, atrial natriuretic peptide (ANP), CaMKII delta and ox-CaMKII delta were determined by western blot and histological studies were performed in cardiac tissue. Our data showed that chronic consumption of S + F exacerbates MetS-induced CH which is related with a higher OS and ox-CaMKII delta.
C1 [Julian Arias-Chavez, David; Mailloux-Salinas, Patrick; Leticia Gomez-Viquez, Norma; Bravo, Guadalupe] Inst Politecn Nacl, Dept Farmacobiol, Ctr Invest & Estudios Avanzados, Calz Tenorios 235, Mexico City 14330, DF, Mexico.
   [Altamirano, Julio] Tecnol Monterrey, Escuela Med & Ciencias Salud, Monterrey, Mexico.
   [Huang, Fengyang] Hosp Infantil Mexico Federico Gomez HIMFG, Lab Farmacol & Toxicol, Mexico City, DF, Mexico.
C3 CINVESTAV - Centro de Investigacion y de Estudios Avanzados del
   Instituto Politecnico Nacional; Instituto Politecnico Nacional - Mexico;
   Tecnologico de Monterrey; Hospital Infantil de Mexico Federico Gomez
RP Gómez-Viquez, NL; Bravo, G (corresponding author), Inst Politecn Nacl, Dept Farmacobiol, Ctr Invest & Estudios Avanzados, Calz Tenorios 235, Mexico City 14330, DF, Mexico.
EM gbravof@yahoo.com
RI Huang, Fengyang/HKW-4302-2023
OI Arias Chavez, David Julian/0000-0002-6663-0043; Bravo,
   Guadalupe/0000-0002-2730-7761; Huang, Fengyang/0000-0002-6503-694X
FU Consejo Nacional de Ciencia y Tecnologia [456311]
FX Funding was provided by Consejo Nacional de Ciencia y Tecnologia
   (456311).
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NR 34
TC 6
Z9 6
U1 0
U2 7
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0300-8177
EI 1573-4919
J9 MOL CELL BIOCHEM
JI Mol. Cell. Biochem.
PD APR
PY 2022
VL 477
IS 4
BP 1309
EP 1320
DI 10.1007/s11010-022-04364-w
EA FEB 2022
PG 12
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA ZQ8HY
UT WOS:000753223800001
PM 35138512
DA 2025-06-11
ER

PT J
AU Putnam, K
   Shoemaker, R
   Yiannikouris, F
   Cassis, LA
AF Putnam, Kelly
   Shoemaker, Robin
   Yiannikouris, Frederique
   Cassis, Lisa A.
TI The renin-angiotensin system: a target of and contributor to
   dyslipidemias, altered glucose homeostasis, and hypertension of the
   metabolic syndrome
SO AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
LA English
DT Review
DE obesity; angiotensinogen; hypercholesterolemia; glucose; insulin
ID DIET-INDUCED OBESITY; II TYPE-1 RECEPTOR; CONVERTING ENZYME-INHIBITORS;
   PROXIMAL TUBULAR CELLS; ABDOMINAL AORTIC-ANEURYSMS; SMOOTH-MUSCLE-CELLS;
   END-POINT REDUCTION; E-DEFICIENT MICE; NF-KAPPA-B; INSULIN-RESISTANCE
AB Putnam K, Shoemaker R, Yiannikouris F, Cassis LA. The renin-angiotensin system: a target of and contributor to dyslipidemias, altered glucose homeostasis, and hypertension of the metabolic syndrome. Am J Physiol Heart Circ Physiol 302: H1219-H1230, 2012. First published January 6, 2012; doi:10.1152/ajpheart.00796.2011.-The renin-angiotensin system (RAS) is an important therapeutic target in the treatment of hypertension. Obesity has emerged as a primary contributor to essential hypertension in the United States and clusters with other metabolic disorders (hyperglycemia, hypertension, high triglycerides, low HDL cholesterol) defined within the metabolic syndrome. In addition to hypertension, RAS blockade may also serve as an effective treatment strategy to control impaired glucose and insulin tolerance and dyslipidemias in patients with the metabolic syndrome. Hyperglycemia, insulin resistance, and/or specific cholesterol metabolites have been demonstrated to activate components required for the synthesis [angiotensinogen, renin, angiotensin-converting enzyme (ACE)], degradation (ACE2), or responsiveness (angiotensin II type 1 receptors, Mas receptors) to angiotensin peptides in cell types (e.g., pancreatic islet cells, adipocytes, macrophages) that mediate specific disorders of the metabolic syndrome. An activated local RAS in these cell types may contribute to dysregulated function by promoting oxidative stress, apoptosis, and inflammation. This review will discuss data demonstrating the regulation of components of the RAS by cholesterol and its metabolites, glucose, and/or insulin in cell types implicated in disorders of the metabolic syndrome. In addition, we discuss data supporting a role for an activated local RAS in dyslipidemias and glucose intolerance/insulin resistance and the development of hypertension in the metabolic syndrome. Identification of an activated RAS as a common thread contributing to several disorders of the metabolic syndrome makes the use of angiotensin receptor blockers and ACE inhibitors an intriguing and novel option for multisymptom treatment.
C1 [Putnam, Kelly; Shoemaker, Robin; Yiannikouris, Frederique; Cassis, Lisa A.] Univ Kentucky, Grad Ctr Nutr Sci, Lexington, KY 40536 USA.
C3 University of Kentucky
RP Cassis, LA (corresponding author), Univ Kentucky, Grad Ctr Nutr Sci, Rm 521B,Wethington Bldg,900 S Limestone, Lexington, KY 40536 USA.
EM lcassis@uky.edu
RI Cassis, Lisa/G-1934-2011
FU National Institutes of Health [HL-073085, P20-RR-021954]; American Heart
   Association [11PRE6760002]; American Heart Association (AHA)
   [11PRE6760002] Funding Source: American Heart Association (AHA)
FX This work was supported by the National Institutes of Health Grants
   HL-073085 (to L. A. Cassis) and P20-RR-021954 (to L. A. Cassis) and by
   American Heart Association Grant 11PRE6760002.
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NR 124
TC 200
Z9 229
U1 0
U2 24
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0363-6135
J9 AM J PHYSIOL-HEART C
JI Am. J. Physiol.-Heart Circul. Physiol.
PD MAR
PY 2012
VL 302
IS 6
BP H1219
EP H1230
DI 10.1152/ajpheart.00796.2011
PG 12
WC Cardiac & Cardiovascular Systems; Physiology; Peripheral Vascular
   Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Physiology
GA 912JD
UT WOS:000301792800001
PM 22227126
OA Green Published
DA 2025-06-11
ER

PT J
AU He, ZYT
   Xu, HF
   Li, CC
   Yang, HY
   Mao, YL
AF He, Zhangyuting
   Xu, Haifeng
   Li, Changcan
   Yang, Huayu
   Mao, Yilei
TI Intermittent fasting and immunomodulatory effects: A systematic review
SO FRONTIERS IN NUTRITION
LA English
DT Review
DE intermittent fasting; immune system; immunomodulatory effect; metabolic
   syndrome; obesity
ID CARDIOMETABOLIC HEALTH; METABOLISM; PERFORMANCE; MECHANISMS; MICROBIOTA;
   RESPONSES; HORMESIS; MARKERS; STRESS; WEIGHT
AB Introductionstrategy of periodic food restriction and fixed eating windows, could beneficially modify individuals by losing body weight, regulating glucose or lipid metabolism, reducing blood pressure, and modulating the immune system. Specific effects of IF and its mechanisms have not yet been assessed collectively. Thus, this systematic review aims to summarize and compare clinical trials that explored the immunomodulatory effects of IF. MethodsAfter screening, 28 studies were included in this systematic review. ResultsIn addition to weight loss, IF could benefit health subjects by strengthening their circadian rhythms, migrating immune cells, lower inflammatory factors, and enriching microbials. In addition of the anti-inflammatory effect by regulating macrophages, protection against oxidative stress with hormone secretion and oxidative-related gene expression plays a key beneficial role for the influence of IF on obese subjects. DiscussionPhysiological stress by surgery and pathophysiological disorders by endocrine diseases may be partly eased with IF. Moreover, IF might be used to treat anxiety and cognitive disorders with its cellular, metabolic and circadian mechanisms. Finally, the specific effects of IF and the mechanisms pertaining to immune system in these conditions require additional studies.
C1 [He, Zhangyuting] Chinese Acad Med Sci & Peking Union Med Coll, Beijing, Peoples R China.
   [Xu, Haifeng; Li, Changcan; Yang, Huayu; Mao, Yilei] PUMC & Chinese Acad Med Sci CAMS, Peking Union Med Coll PUMC Hosp, Dept Liver Surg, Beijing, Peoples R China.
C3 Chinese Academy of Medical Sciences - Peking Union Medical College;
   Peking Union Medical College
RP Yang, HY; Mao, YL (corresponding author), PUMC & Chinese Acad Med Sci CAMS, Peking Union Med Coll PUMC Hosp, Dept Liver Surg, Beijing, Peoples R China.
EM pumch-liver@hotmail.com; dolphinyahy@hotmail.com
RI Miao, Liyun/JXM-6258-2024; Xu, Haifeng/AIC-5767-2022
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NR 63
TC 8
Z9 8
U1 3
U2 18
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD FEB 28
PY 2023
VL 10
AR 1048230
DI 10.3389/fnut.2023.1048230
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 9U7CS
UT WOS:000947865200001
PM 36925956
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Girod, JP
   Brotman, DJ
AF Girod, JP
   Brotman, DJ
TI Does altered glucocorticoid homeostasis increase cardiovascular risk?
SO CARDIOVASCULAR RESEARCH
LA English
DT Review
DE hypothalamic-pituitary-adrenal axis; glucocorticoids; metabolic
   syndrome; stress response
ID PITUITARY-ADRENAL AXIS; 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1;
   CORTICOTROPIN-RELEASING HORMONE; HUMAN ADIPOSE-TISSUE; C-REACTIVE
   PROTEIN; VASCULAR ENDOTHELIAL-CELLS; HIGH-DENSITY-LIPOPROTEIN;
   SKELETAL-MUSCLE CELLS; NF-KAPPA-B; GENE-EXPRESSION
AB The hypothalamic-pituitary-adrenal (HPA) axis, like the sympathetic nervous system and the renin-angiotensin-aldosterone (RAA) system, sustains life in stressful situations by increasing vascular tone and ensuring fuel availability. It also modulates inflammation and tissue repair processes. Untoward cardiovascular effects of chronic sympathetic and RAA activation are well recognized, illustrating that the short-term benefit of the physiologic stress response can be detrimental in the long term. Similarly, chronic tissue exposure to glucocorticoids may lead to metabolic and vascular changes that accelerate vascular senescence. Specific situations associated with chronic activation of the HPA axis-such as major depression, inflammatory disease and perhaps the metabolic syndrome-may derive some of their associated cardiovascular risk from untoward glucocorticoid effects. Since there are no definitive clinical studies directly addressing the relationship between the HPA axis and cardiovascular disease, we present indirect evidence from two types of studies: (1) studies that examine the cardiovascular effects of exogenous glucocorticoids, and (2) studies demonstrating that endogenous glucocorticoid activity varies between individuals. The effects of physiologic increases in endogenous glucocorticoid activity may not always mirror the effects of supraphysiologic glucocorticoids. Nevertheless, the known effects of exogenous glucocorticoids provide important insights into the putative effects of endogenous glucocorticoids. (C) 2004 European Society of Cardiology. Published by Elsevier B.V. All rights reserved.
C1 Cleveland Clin Fdn, Dept Gen Internal Med S70, Hosp Med Fellowship, Cleveland, OH 44195 USA.
C3 Cleveland Clinic Foundation
RP Cleveland Clin Fdn, Dept Gen Internal Med S70, Hosp Med Fellowship, 9500 Euclid Ave, Cleveland, OH 44195 USA.
EM brotmad@ccf.org
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NR 142
TC 148
Z9 166
U1 0
U2 11
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0008-6363
EI 1755-3245
J9 CARDIOVASC RES
JI Cardiovasc. Res.
PD NOV 1
PY 2004
VL 64
IS 2
BP 217
EP 226
DI 10.1016/j.cardiores.2004.07.006
PG 10
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 867YX
UT WOS:000224880100006
PM 15485680
OA Bronze
DA 2025-06-11
ER

PT J
AU Aroor, AR
   Mandavia, C
   Ren, J
   Sowers, JR
   Pulakat, L
AF Aroor, Annayya R.
   Mandavia, Chirag
   Ren, Jun
   Sowers, James R.
   Pulakat, Lakshmi
TI Mitochondria and Oxidative Stress in the Cardiorenal Metabolic Syndrome
SO CARDIORENAL MEDICINE
LA English
DT Article
DE Cardiorenal syndrome; Overnutrition; Mitochondria; NADPH oxidase;
   Angiotensin II; MicroRNA; Alcoholic cardiomyopathy
ID ENDOPLASMIC-RETICULUM STRESS; ACTIVATED PROTEIN-KINASE; FATTY
   LIVER-DISEASE; RECEPTOR-GAMMA COACTIVATOR-1; SKELETAL-MUSCLE;
   INSULIN-RESISTANCE; ANGIOTENSIN-II; ALCOHOL-CONSUMPTION; NADPH OXIDASE;
   GENE-EXPRESSION
AB Mitochondria play a fundamental role in the maintenance of normal structure, function, and survival of tissues. There is considerable evidence for mitochondrial dysfunction in association with metabolic diseases including insulin resistance, obesity, diabetes, and the cardiorenal metabolic syndrome. The phenomenon of reactive oxygen species (ROS)-induced ROS release through interactions between cytosolic and mitochondrial oxidative stress contributes to a vicious cycle of enhanced oxidative stress and mitochondria! dysfunction. Activation of the cytosolic and mitochondria! NADPH oxidase system, impairment of the mitochondrial electron transport, activation of p66shc pathway-targeting mitochondria, endoplasmic reticular stress, and activation of the mammalian target of the rapamycin-S6 kinase pathway underlie dysregulation of mitochondrial dynamics and promote mitochondrial oxidative stress. These processes are further modulated by acetyltransferases including sirtuin 1 and sirtuin 3, the former regulating nuclear acetylation and the latter regulating mitochondrial acetylation. The regulation of mitochondrial functions by microRNAs forms an additional layer of molecular control of mitochondrial oxidative stress. Alcohol further exacerbates mitochondrial oxidative stress induced by overnutrition and promotes the development of metabolic diseases. Copyright (C) 2012 S. Karger AG, Basel
C1 [Aroor, Annayya R.; Mandavia, Chirag; Sowers, James R.; Pulakat, Lakshmi] Univ Missouri, Sch Med, Dept Internal Med, Columbia, MO USA.
   [Pulakat, Lakshmi] Univ Missouri, Sch Med, Dept Nutr & Exercise Physiol, Columbia, MO USA.
   [Sowers, James R.] Univ Missouri, Sch Med, Dept Med Pharmacol & Physiol, Columbia, MO USA.
   [Aroor, Annayya R.; Mandavia, Chirag; Sowers, James R.; Pulakat, Lakshmi] Univ Missouri, Sch Med, Diabet & Cardiovasc Lab, Columbia, MO USA.
   [Aroor, Annayya R.; Mandavia, Chirag; Sowers, James R.; Pulakat, Lakshmi] Harry S Truman Vet Affair Med Ctr, Columbia, MO USA.
   [Ren, Jun] Univ Wyoming, Coll Hlth Sci, Ctr Cardiovasc Res & Alternat Med, Laramie, WY 82071 USA.
C3 University of Missouri System; University of Missouri Columbia;
   University of Missouri System; University of Missouri Columbia;
   University of Missouri System; University of Missouri Columbia;
   University of Missouri System; University of Missouri Columbia; US
   Department of Veterans Affairs; Veterans Health Administration (VHA);
   Harry S. Truman Memorial Veterans' Hospital; University of Wyoming
RP Pulakat, L (corresponding author), D109 HSC Diabet Ctr,1 Hosp Dr, Columbia, MO 65212 USA.
EM pulakatl@health.missouri.edu
RI Ren, Jun/ACG-5366-2022
OI Ren, Jun/0000-0002-0275-0783
FU NIH [R01 HL73101-01A1, R01 HL107910-01]; Veterans Affairs Merit System
   [0018]; University of Missouri; Forest Laboratories
FX This research was supported by the NIH (R01 HL73101-01A1 and R01
   HL107910-01 to J.R.S.), the Veterans Affairs Merit System 0018 (to
   J.R.S.) and the University of Missouri Mission Enhancement Fund and
   Forest Laboratories (to L.P.). The authors would like to thank Brenda
   Hunter for her assistance in editing the manuscript.
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NR 216
TC 53
Z9 58
U1 1
U2 22
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1664-3828
EI 1664-5502
J9 CARDIORENAL MED
JI CardioRenal Med.
PY 2012
VL 2
IS 2
BP 87
EP 109
DI 10.1159/000335675
PG 23
WC Cardiac & Cardiovascular Systems; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Urology & Nephrology
GA 051ZP
UT WOS:000312167800002
PM 22619657
OA Green Published
DA 2025-06-11
ER

PT J
AU Solís-Pérez, E
   Mar-Buruato, AM
   Tijerina-Sáenz, A
   Sánchez-Peña, MA
   González-Martínez, BE
   Lavalle-González, FJ
   Villarreal-Pérez, JZ
   Sánchez-Solís, G
   Lomelí, MLC
AF Solis-Perez, Elizabeth
   Mar-Buruato, Ana Marina
   Tijerina-Saenz, Alexandra
   Sanchez-Pena, Maria Alejandra
   Gonzalez-Martinez, Blanca Edelia
   Lavalle-Gonzalez, Fernando Javier
   Villarreal-Perez, Jesus Zacarias
   Sanchez-Solis, Gerardo
   Lopez-Cabanillas Lomeli, Manuel
TI Adipokines and Gamma-Glutamyl Transferase as Biomarkers of Metabolic
   Syndrome Risk in Mexican School-Aged Children
SO NUTRIENTS
LA English
DT Article
DE adipokines; gamma-glutamyl transferase (GGT); metabolic syndrome;
   children
ID INSULIN-RESISTANCE; GLUTAMYLTRANSFERASE; DYSFUNCTION; ADOLESCENTS;
   MARKERS; OBESITY; HEALTH
AB Background/Objectives: The prevalence of metabolic syndrome in children has been increasing, raising concerns about early detection and clinical management. Adipokines, which are secreted by adipose tissue, play a critical role in metabolic regulation and inflammation, while gamma-glutamyl transferase (GGT), as a liver enzyme, is linked to oxidative stress and metabolic disorders. The objective was to examine the association of circulating adipokines and GGT with metabolic syndrome risk in school-aged children from Northeast Mexico. Methods: A total of 140 children from 6 to 12 years of age in the state of Nuevo Le & oacute;n, Mexico, participated in this study. Obesity was classified according to the BMI z-score by the World Health Organization (WHO, 2007), and metabolic syndrome was classified according to the International Diabetes Federation (IDF, 2007). Serum levels of leptin, adiponectin, TNF-alpha, IL-6, and GGT were measured. Statistical analysis was performed using the Student's t-test, simple linear regression analysis, and receiver operating characteristic (ROC) curve analysis. Results: Among the 140 participants, 60 children (43%) were classified as obese, and of those children with obesity, 55% were diagnosed with metabolic syndrome. Leptin was significantly associated with waist circumference (WC), systolic blood pressure (SBP), serum glucose, triglycerides, and HDL cholesterol (HDL-c). Adiponectin also showed significant associations with WC, SBP, serum triglycerides, and HDL-c. GGT was significantly correlated with WC and HDL-c, while IL-6 and TNF-alpha did not indicate significance. Associations were observed among leptin, adiponectin, and GGT, highlighting their combined role as potential markers for metabolic syndrome in children. The ROC curve analysis and Youden's index provided cut-off points for these biomarkers: leptin: 8.3665 ng/mL, adiponectin: 9.87 mu g/mL, GGT: 17.8 U/L, IL-6 2.77 pg/mL, and TNF-alpha: 6.68 pg/mL; Conclusions: These findings emphasize the utility of leptin, adiponectin, and GGT as early biomarkers for identifying children with obesity who are at risk of developing metabolic syndrome.
C1 [Solis-Perez, Elizabeth; Mar-Buruato, Ana Marina; Tijerina-Saenz, Alexandra; Sanchez-Pena, Maria Alejandra; Gonzalez-Martinez, Blanca Edelia; Lopez-Cabanillas Lomeli, Manuel] Univ Autonoma Nuevo Leon UANL, Fac Salud Publ & Nutr FaSPyN, Monterrey 64460, Nuevo Leon, Mexico.
   [Lavalle-Gonzalez, Fernando Javier; Villarreal-Perez, Jesus Zacarias; Sanchez-Solis, Gerardo] Univ Autonoma Nuevo Leon UANL, Hosp Univ Dr Jose Eleuterio Gonzalez, Serv Endocrinol, Monterrey 64460, Nuevo Leon, Mexico.
C3 Universidad Autonoma de Nuevo Leon; Universidad Autonoma de Nuevo Leon;
   University Hospital Autonomous University of Nuevo Leon
RP Lomelí, MLC (corresponding author), Univ Autonoma Nuevo Leon UANL, Fac Salud Publ & Nutr FaSPyN, Monterrey 64460, Nuevo Leon, Mexico.
EM elizabeth.solis@uanl.mx; ana.marbr@uanl.edu.mx;
   alexandra.tijerinas@uanl.mx; maria.sanchezpn@uanl.edu.mx;
   blanca.gonzalezma@uanl.mx; fernando.lavallegn@uanl.edu.mx;
   zacvilla@yahoo.com.mx; gerardo.sanchezsls@uanl.edu.mx;
   manuel.lopezc@uanl.mx
RI Solis-Pérez, Elizabeth/AAP-7954-2021
OI Tijerina Saenz, Alexandra/0000-0002-3154-2633; SOLIS PEREZ,
   ELIZABETH/0000-0002-3702-3607; Villarreal-Perez, Jesus
   Zacarias/0000-0002-6814-062X; Gonzalez Martinez, Blanca
   Edelia/0000-0003-2999-358X; SANCHEZ PENA, MARIA
   ALEJANDRA/0000-0001-7680-8805; Sanchez Solis,
   Gerardo/0009-0001-4093-9413; Lopez-Cabanillas Lomeli,
   Manuel/0000-0002-6033-3654; Lavalle-Gonzalez,
   Fernando/0000-0001-8820-5366
FU Programa de Apoyo a la Investigacion Cientifica y Tecnologica
   UANL-PAICYT [SA1957-21]; General and Endrocrinology laboratories of UANL
   Hospital Universitario; Universidad Autonoma de Nuevo Leon; Facultad de
   Salud Publica y Nutricion
FX This research was funded by the Programa de Apoyo a la Investigacion
   Cientifica y Tecnologica UANL-PAICYT 2021, grant number SA1957-21, the
   General and Endrocrinology laboratories of UANL Hospital Universitario,
   Dr. Jose Eleuterio Gonzalez, Universidad Autonoma de Nuevo Leon,
   Facultad de Salud Publica y Nutricion.
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NR 36
TC 0
Z9 0
U1 0
U2 0
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD DEC
PY 2024
VL 16
IS 24
AR 4410
DI 10.3390/nu16244410
PG 14
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA Q4M0W
UT WOS:001384431600001
PM 39771030
OA gold
DA 2025-06-11
ER

PT J
AU Prescott, E
   Godtfredsen, N
   Osler, M
   Schnohr, P
   Barefoot, J
AF Prescott, Eva
   Godtfredsen, Nina
   Osler, Merete
   Schnohr, Peter
   Barefoot, John
TI Social gradient in the metabolic syndrome not explained by psychosocial
   and behavioural factors: evidence from the Copenhagen City Heart Study
SO EUROPEAN JOURNAL OF CARDIOVASCULAR PREVENTION & REHABILITATION
LA English
DT Article
DE education; inflammation; metabolic syndrome; preventive cardiology;
   psychosocial factors; socio-economic status
ID MIDDLE-AGED MEN; EMPLOYMENT GRADE DIFFERENCES; ACUTE
   MYOCARDIAL-INFARCTION; CORONARY-ARTERY-DISEASE; ALL-CAUSE MORTALITY;
   SOCIOECONOMIC-STATUS; WHITEHALL-II; RISK-FACTORS;
   CARDIOVASCULAR-DISEASE; MAJOR DEPRESSION
AB Background Psychosocial stressors may mediate the effect of social status on the metabolic syndrome (MS). The paper explores this hypothesis in a random sample of the general population.
   Design A total of 3462 women and 2576 men aged 20-97 years from the Copenhagen City Heart Study.
   Methods An MS index was defined from the seven components: waist-hip ratio, high-density lipoprotein (HDL)cholesterol, triglycerides, systolic blood pressure (SBP), blood glucose, C-reactive protein (CRP) and fibrinogen. Social status was measured by educational level. Psychosocial factors included fatigue and depression, perceived stress, social network and cohabitation. Behavioural factors were smoking, alcohol and physical activity.
   Results There was an inverse social gradient in the prevalence of the seven components of the MS. The age-adjusted odds ratio (OR) (95% confidence interval) for occupying the most disadvantaged quintile, comparing highest with lowest educational level, were for men and women, respectively: waist-hip ratio 0.48 (0.34-0.69) and 0.48 (0.33-0.69); HDL-cholesterol 0.61 (0.45-0.84) and 0.46 (0.33-0.64); triglycerides 0.71 (0.51-0.98) and 0.37 (0.25-0.53); SBP 0.64 (0.44-0.92) and 0.76 (0.50-1.15); blood glucose 0.57 (0.41-0.80) and 0.55 (0.38-0.78); CRP 0.53 (0.37-0.74) and 0.44 (0.31-0.63), and fibrinogen 0.50 (0.35-0.70) and 0.56 (0.38-0.82). The pooled OR for having an MS index score of 3 or more was 0.32 (0.24-0.42) for highest versus lowest educational level. A higher fatigue and depression score in both sexes and a lack of social support in men were associated with the MS, as were smoking, low alcohol consumption and a lack of physical activity. However, OR for educational level were not affected by adjustment for the psychosocial or behavioural factors.
   Conclusions There is a strong inverse social gradient in the prevalence of the MS, which is not explained by psychosocial or major behavioural factors.
C1 Bispebjerg Hosp, Dept Cardiol, DK-2400 Copenhagen NV, Denmark.
   Copenhagen City Heart Study, DK-2400 Copenhagen NV, Denmark.
   Inst Hlth Serv Res, Epidemiol Unit, DK-5000 Odense, Denmark.
   Duke Univ, Med Ctr, Dept Psychiat & Behav Sci, Durham, NC 27710 USA.
C3 University of Copenhagen; Bispebjerg Hospital; Copenhagen University
   Hospital; Duke University
RP Prescott, E (corresponding author), Bispebjerg Hosp, Dept Cardiol, Bispebjerg Bakke 23, DK-2400 Copenhagen NV, Denmark.
EM eva@prescott.dk
RI Prescott, Eva/AAJ-7441-2020; Osler, Merete/AAF-7885-2019
OI Prescott, Eva/0000-0002-4134-0349; Osler, Merete/0000-0002-6921-220X
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NR 52
TC 39
Z9 48
U1 0
U2 3
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1741-8267
EI 1741-8275
J9 EUR J CARDIOV PREV R
JI Eur. J. Cardiovasc. Prev. Rehabil.
PD JUN
PY 2007
VL 14
IS 3
BP 405
EP 412
DI 10.1097/HJR.0b013e32800ff169
PG 8
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 187BK
UT WOS:000247822100009
PM 17568240
OA Bronze
DA 2025-06-11
ER

PT J
AU Maitiniyazi, G
   Chen, Y
   Qiu, YY
   Xie, ZX
   He, JY
   Xia, SF
AF Maitiniyazi, Gusonghan
   Chen, Yue
   Qiu, Yu-Yu
   Xie, Zhen-Xing
   He, Jian-Yun
   Xia, Shu-Fang
TI Characteristics of Body Composition and Lifestyle in Chinese University
   Students with Normal-Weight Obesity: A Cross-Sectional Study
SO DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
LA English
DT Article
DE obesity; body fat; physical exercise; dietary nutrition; stress
   management; public health
ID MASS INDEX; DIAGNOSTIC PERFORMANCE; CARDIOMETABOLIC RISK; IDENTIFY
   OBESITY; PREVALENCE; STRESS; US; ADIPOSITY; CHILDREN; DIETARY
AB Purpose: Normal weight obesity (NWO), defined as normal body mass index (BMI) and excessive body fat percentage (BF%), has been shown to be associated with a significantly higher risk of developing metabolic syndrome, cardiometabolic dysfunction and with higher mortality. However, there is limited literature regarding the potential associations between NWO and lifestyles. This study aimed to investigate the associations of lifestyles with NWO in Chinese university students.
   Participants and Methods: A total of 279 university students with normal BMI were recruited and divided into NWO and normal weight non-obesity (NWNO) groups by BF%. Body composition and anthropometrics were measured, and participants were asked to finish the Healthy Lifestyle Scale for University Students (HLSUS) questionnaire.
   Results: A total of 26 male (25.5%) and 71 female (40.1%) students were identified as NWO. Compared to NWNO students, body weight, BMI, body fat mass, visceral fat area, waist circumference and hip circumference of NWO students were all significantly higher both in male and female students (P < 0.05). The body fat mass, BF% and visceral fat area were significantly negatively correlated with the total HLSUS, physical exercise behavior, and dietary nutrition behavior scores in NWNO males, NWO and NWNO females (P < 0.05). The risk of NWO was lower in those students with higher scores in physical exercise behavior in both males (OR = 0.298, 95% CI = 0.121 similar to 0.733) and females (OR = 0.653, 95% CI = 0.505 similar to 0.843), while dietary nutrition behavior (OR = 0.759, 95% CI = 0.584 similar to 0.986) and stress management behavior (OR = 0.503, 95% CI = 0.335 similar to 0.755) decreased the risk of NWO only in females.
   Conclusion: The incidence of NWO was high among university students, especially in females, which might be related with unhealthy lifestyles. NWO university students should pay attention to lifestyle adjustments, especially physical exercise, dietary nutrition and stress management, for preventing the health risk in NWO.
C1 [Maitiniyazi, Gusonghan; Chen, Yue; Qiu, Yu-Yu; He, Jian-Yun; Xia, Shu-Fang] Jiangnan Univ, Wuxi Sch Med, Lihu Ave 1800, Wuxi 214122, Jiangsu, Peoples R China.
   [Xie, Zhen-Xing] Henan Univ, Sch Basic Med, Kaifeng, Henan, Peoples R China.
C3 Jiangnan University; Henan University
RP Maitiniyazi, G (corresponding author), Jiangnan Univ, Wuxi Sch Med, Lihu Ave 1800, Wuxi 214122, Jiangsu, Peoples R China.
EM xiashufang@jiangnan.edu.cn
RI Xia, Shu-Fang/E-6623-2016
OI Xia, Shu-Fang/0000-0002-8977-4760
FU National Natural Science Foundation of China [81703222]; China
   Postdoctoral Science Foundation [2017M620191]; Postdoctoral Foundation
   of Jiangsu Province [1701099B]
FX This research was funded by the National Natural Science Foundation of
   China, grant number 81703222; China Postdoctoral Science Foundation,
   grantnumber 2017M620191; Postdoctoral Foundation of Jiangsu Province,
   grant number 1701099B.
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NR 47
TC 15
Z9 15
U1 4
U2 40
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-7007
J9 DIABET METAB SYND OB
JI Diabetes Metab. Syndr. Obes.
PY 2021
VL 14
BP 3427
EP 3436
DI 10.2147/DMSO.S325115
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA TR1IQ
UT WOS:000678725800001
PM 34349536
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Heinzer, R
   Marti-Soler, H
   Marques-Vidal, P
   Tobback, N
   Andries, D
   Waeber, G
   Preisig, M
   Vollenweider, P
   Haba-Rubio, J
AF Heinzer, Raphael
   Marti-Soler, Helena
   Marques-Vidal, Pedro
   Tobback, Nadia
   Andries, Daniela
   Waeber, Gerard
   Preisig, Martin
   Vollenweider, Peter
   Haba-Rubio, Jose
TI Impact of sex and menopausal status on the prevalence, clinical
   presentation, and comorbidities of sleep-disordered breathing
SO SLEEP MEDICINE
LA English
DT Article
DE Sleep apnea; Menopause; Hypertension; Diabetes; Metabolic syndrome;
   Depression
ID POSITIVE AIRWAY PRESSURE; GENDER-DIFFERENCES; DAYTIME SLEEPINESS; APNEA;
   POPULATION; WOMEN; SEVERITY; RISK; QUESTIONNAIRE; EVENTS
AB Objective: Sleep-disordered breathing (SDB) is currently considered as a unique condition, but it has been suggested that the prevalence, clinical presentation, and associated conditions may differ by sex or by menopausal status in women. We aimed to assess the prevalence of SDB and associated comorbidities in pre- and postmenopausal women compared with men.
   Methods: Participants of the population-based HypnoLaus Sleep Cohort study underwent polysomnography in their home environment and had extensive phenotyping for diabetes, hypertension, metabolic syndrome, and depression.
   Results: A total of 2121 subjects (age 40-85 [59 +/- 11] years, body mass index 25.6 +/- 4.1 kg/m(2), 1024 men and 1097 women [769 postmenopausal]) were included. SDB prevalence based on an apnea-hypopnea index of >5/h, >15/11, >20/11, and >= 30/h, respectively, was 83.8%, 49.7%, 37.5%, and 22.0% in men; 35.1%, 8.6%, 3.3%, and 1.3% in premenopausal women; and 71.6%, 29.4%, 20.7%, and 10.1% in postmenopausal women. In multivariable models, SDB severity was significantly associated with hypertension in women (p = 0.007) (mainly in postmenopausal women) but not in men (p = 0.065), with diabetes in men (p = 0.021) but not in women overall (p = 0.853) or in postmenopausal women (p = 0.725), with metabolic syndrome in men (p = 0.002) and women (p < 0.001), and with depression in women (p = 0.007) but not in men (p = 0.853).
   Conclusion: SDB prevalence in this middle-aged to-older population was high, particularly in men and postmenopausal women. SDB was associated with hypertension and depression exclusively in women, whereas an association with diabetes was present only in men. These findings suggest that the SDB definition and management recommendations may need to be adapted to these groups' specificities. (C) 2018 Elsevier B.V. All rights reserved.
C1 [Heinzer, Raphael; Tobback, Nadia; Andries, Daniela; Haba-Rubio, Jose] CIRS, Lausanne, Switzerland.
   [Heinzer, Raphael] Univ Hosp Lausanne, Pulm Dept, Lausanne, Switzerland.
   [Marti-Soler, Helena] Univ Lausanne, Inst Social & Prevent Med, Lausanne, Switzerland.
   [Marques-Vidal, Pedro; Waeber, Gerard; Vollenweider, Peter] Univ Hosp Lausanne, Dept Med, Internal Med, Lausanne, Switzerland.
   [Preisig, Martin] Univ Hosp Lausanne, Psychiat Dept, Lausanne, Switzerland.
C3 University of Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV);
   University of Lausanne; University of Lausanne; Centre Hospitalier
   Universitaire Vaudois (CHUV); University of Lausanne; Centre Hospitalier
   Universitaire Vaudois (CHUV)
RP Heinzer, R (corresponding author), Lausanne Univ, Lausanne Univ Hosp Lausanne CHUV, Ctr Invest & Res Sleep, Rue Bugnon 46, CH-1011 Lausanne, Vaud, Switzerland.; Heinzer, R (corresponding author), Lausanne Univ, Lausanne Univ Hosp Lausanne CHUV, Pulm Dept, Rue Bugnon 46, CH-1011 Lausanne, Vaud, Switzerland.
EM raphael.heinzer@chuv.ch
RI Marti-Soler, Helena/AAA-7659-2019; Preisig, Martin/H-3441-2016;
   Marques-Vidal, Pedro/C-9449-2009; Vollenweider, Peter/Q-4603-2016
OI Heinzer, Raphael/0000-0002-3215-7788; Waeber,
   Gerard/0000-0003-4193-788X; Marti-Soler, Helena/0000-0002-7127-205X;
   Marques-Vidal, Pedro/0000-0002-4548-8500; Preisig,
   Martin/0000-0001-5689-4259; Vollenweider, Peter/0000-0002-0765-896X
FU GlaxoSmithKline; Faculty of Biology and Medicine of Lausanne; Swiss
   National Science Foundation [3200B0-105993, 3200B0-118308,
   33CSCO-122661, 33CS30-139468, 33CS30-148401]; Leenaards Foundation; Vaud
   Pulmonary League (Ligue Pulmonaire Vaudoise)
FX The HypnoLaus and the CoLaus/PsyCoLaus study were and are supported by
   research grants from GlaxoSmithKline, the Faculty of Biology and
   Medicine of Lausanne, the Swiss National Science Foundation (grants
   3200B0-105993, 3200B0-118308, 33CSCO-122661, 33CS30-139468 and
   33CS30-148401), Leenaards Foundation, and Vaud Pulmonary League (Ligue
   Pulmonaire Vaudoise).
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NR 43
TC 58
Z9 64
U1 1
U2 7
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1389-9457
EI 1878-5506
J9 SLEEP MED
JI Sleep Med.
PD NOV
PY 2018
VL 51
BP 29
EP 36
DI 10.1016/j.sleep.2018.04.016
PG 8
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA GX5IF
UT WOS:000447778200006
PM 30081384
DA 2025-06-11
ER

PT J
AU Jamshidi, N
   Cohen, MM
AF Jamshidi, Negar
   Cohen, Marc M.
TI The Clinical Efficacy and Safety of Tulsi in Humans: A Systematic Review
   of the Literature
SO EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Review
ID OCIMUM-SANCTUM LINN.; ESSENTIAL OIL; LEAF EXTRACT; HOLY BASIL; LEAVES;
   GRATISSIMUM; ANTIOXIDANT; PARAMETERS; EUGENOL; SUPPLEMENTATION
AB Tulsi, also known as holy basil, is indigenous to the Indian continent and highly revered for its medicinal uses within the Ayurvedic and Siddha medical systems. Many in vitro, animal and human studies attest to tulsi having multiple therapeutic actions including adaptogenic, antimicrobial, anti-inflammatory, cardioprotective, and immunomodulatory effects, yet to date there are no systematic reviews of human research on tulsi's clinical efficacy and safety. We conducted a comprehensive literature review of human studies that reported on a clinical outcome after ingestion of tulsi. We searched for studies published in books, theses, conference proceedings, and electronic databases including Cochrane Library, Google Scholar, Embase, Medline, PubMed, Science Direct, and Indian Medical databases. A total of 24 studies were identified that reported therapeutic effects on metabolic disorders, cardiovascular disease, immunity, and neurocognition. All studies reported favourable clinical outcomes with no studies reporting any significant adverse events. The reviewed studies reinforce traditional uses and suggest tulsi is an effective treatment for lifestyle-related chronic diseases including diabetes, metabolic syndrome, and psychological stress. Further studies are required to explore mechanisms of action, clarify the dosage and dose form, and determine the populations most likely to benefit from tulsi's therapeutic effects.
C1 [Jamshidi, Negar; Cohen, Marc M.] RMIT Univ, Sch Hlth & Biomed Sci, Melbourne, Vic, Australia.
C3 Royal Melbourne Institute of Technology (RMIT)
RP Cohen, MM (corresponding author), RMIT Univ, Sch Hlth & Biomed Sci, Melbourne, Vic, Australia.
EM marc.cohen@rmit.edu.au
RI Cohen, Marc/GWV-0933-2022; Jamshidi, Negar/J-6136-2019
OI Jamshidi, Negar/0000-0003-2861-2140; Cohen, Marc/0000-0002-5876-6565
FU RMIT University Scholarship
FX Negar Jamshidi is a Ph.D. student supported by an RMIT University
   Scholarship.
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NR 99
TC 74
Z9 82
U1 0
U2 16
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1741-427X
EI 1741-4288
J9 EVID-BASED COMPL ALT
JI Evid.-based Complement Altern. Med.
PY 2017
VL 2017
AR 9217567
DI 10.1155/2017/9217567
PG 13
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA ER1NF
UT WOS:000398557400001
PM 28400848
OA Green Published, hybrid, Green Submitted
DA 2025-06-11
ER

PT J
AU Sen, S
   Duman, R
   Sanacora, G
AF Sen, Srijan
   Duman, Ronald
   Sanacora, Gerard
TI Serum brain-derived neurotrophic factor, depression, and antidepressant
   medications: Meta-analyses and implications
SO BIOLOGICAL PSYCHIATRY
LA English
DT Article
DE depressive; mood; neurotrophic stress
ID FACTOR BDNF LEVELS; GROWTH-FACTOR; METABOLIC SYNDROME; DECREASED LEVELS;
   PLASMA BDNF; RAT-BRAIN; EXERCISE; ASSOCIATION; EXPRESSION; INCREASES
AB Background: Converging lines of evidence implicate the neurotrophin brain-derived neurotrophic factor (BDNF) in the pathophysiology of major depression. Recent studies have begun to explore the relationship between serum BDNF and depression.
   Methods: We conducted meta-analyses of 11 studies examining differences in serum BDNF content between depressed and nondepressed subjects (N = 748), and eight studies comparing pre- and post-antidepressant treatment serum BDNF content (N = 220).
   Results: The meta-analysis revealed strong evidence that BDNF levels were lower in depressed subjects than healthy control subjects (p < 6.8 X 10(-8)). Similarly, the second meta-analysis found significantly higher BDNF levels after antidepressant treatment (p =.003). There was no evidence of publication bias in the first (p =.376) or second (p =.571) meta-analysis and no evidence that either meta-analysis was unduly influenced by any one study.
   Conclusions: These findings provide strong evidence to suggest that serum BDNF levels are abnormally low in patients suffering from major depressive disorder and that the BDNF levels are elevated following a course of antidepressant treatment. Although the relationship of our findings to pathophysiology of depression and the mechanism of drug action remains to be determined, the measure may have potential use as a biomarker for psychiatric disorders or as a predictor of antidepressant efficacy.
C1 [Sen, Srijan; Duman, Ronald; Sanacora, Gerard] Yale Univ, Sch Med, Connecticut Mental Hlth Ctr, Dept Psychiat, New Haven, CT 06519 USA.
   [Duman, Ronald] Yale Univ, Sch Med, Connecticut Mental Hlth Ctr, Dept Pharmacol, New Haven, CT 06519 USA.
C3 Yale University; Yale University
RP Sanacora, G (corresponding author), Yale Univ, Sch Med, Connecticut Mental Hlth Ctr, Dept Psychiat, 34 Pk St, New Haven, CT 06519 USA.
EM gerard.sanacora@yale.edu
RI Sen, Srijan/J-8053-2013; Sanacora, Gerard/AAF-1135-2019
OI Sen, Srijan/0000-0003-4495-495X
FU National Institute of Mental Health (NIMH) [K02 MH076222-01];
   Connecticut Mental Health Center; NIMH [MH045481, MH025642]; Donagbue
   Foundation; Mary Freedman Foundation; Taisho; Lilly; Wyeth-Ayerst;
   Roche, Sepracor; Psychogenics; Takeda; Organon; Abbott; AstraZeneca;
   Bristol-Myers Squibb; Lundbeck; Pfizer; Roche; Ruxton; sepracor
FX This work was supported by National Institute of Mental Health (NIMH)
   Grant No. K02 MH076222-01 (to GS), the veterans Affairs Research
   Enhancement Awards Program and the Connecticut Mental Health Center (to
   SS, RD, GS) NIMH Grant Nos. MH045481 and MH025642 (to RSD), the Donagbue
   Foundation (SS), and the Daniel X., and Mary Freedman Foundation (SS).
   Dr. Sen has no biomedical financial interests or potential conflicts of
   interest. Dr. Duman has received consulting and/or research funds from
   Taisho, Lilly, Wyeth-Ayerst, Roche, Sepracor, Psychogenics, Takeda, and
   Organon. Dr.Sanacora has received consulting and/or research funds from
   Abbott, AstraZeneca, Bristol-Myers Squibb, Lilly, Lundbeck, Pfizer,
   Roche, Ruxton, and sepracor.
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NR 50
TC 938
Z9 1043
U1 2
U2 88
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0006-3223
EI 1873-2402
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD SEP 15
PY 2008
VL 64
IS 6
BP 527
EP 532
DI 10.1016/j.biopsych.2008.05.005
PG 6
WC Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Psychiatry
GA 343YJ
UT WOS:000258892000013
PM 18571629
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Roddy, GW
   Rosa, RH
   Viker, KB
   Holman, BH
   Hann, CR
   Krishnan, A
   Gores, GJ
   Bakri, SJ
   Fautsch, MP
AF Roddy, Gavin W.
   Rosa, Robert H., Jr.
   Viker, Kimberly B.
   Holman, Bradley H.
   Hann, Cheryl R.
   Krishnan, Anuradha
   Gores, Gregory J.
   Bakri, Sophie J.
   Fautsch, Michael P.
TI Diet Mimicking "Fast Food" Causes Structural Changes to the Retina
   Relevant to Age-Related Macular Degeneration
SO CURRENT EYE RESEARCH
LA English
DT Article
DE Drusen; basal laminar deposits; macular degeneration; metabolic syndrome
ID BASAL LAMINAR DEPOSIT; METABOLIC SYNDROME; PIGMENT EPITHELIUM;
   PHYSICAL-ACTIVITY; BRUCHS MEMBRANE; TRANSGENIC MICE; SERUM-LIPIDS;
   RISK-FACTORS; FAT; INFLAMMATION
AB Introduction: Metabolic syndrome is a disorder characterized by a constellation of findings including truncal obesity, elevated blood pressure, abnormal cholesterol levels, and high blood glucose. Recent evidence suggests that metabolic syndrome may be associated with increased risk of age-related macular degeneration (AMD) and other eye diseases. Recently, C57BL/6J wild-type mice fed with a "fast food" diet consisting of high fat, cholesterol, and fructose-supplemented water showed unique systemic pathology consistent with metabolic syndrome and nonalcoholic steatohepatitis. Additionally, these mice showed higher levels of fibrosis, inflammation, endoplasmic reticulum stress, and mitochondrial dysfunction compared to mice fed with only a high-fat diet alone. Since similar pathways are activated in AMD, we sought to determine whether mice fed a "fast food" diet exhibited retinal changes. Methods: 3-month-old wild-type mice were randomized to a standard chow (n = 11) or a "fast food" (n = 18) diet and fed for 9 months. At 1 year of age, tissues were collected and retinas were analyzed using transmission electron microscopy. Quantitative measures of Bruch's membrane thickness and retinal pigment epithelium (RPE) cell counts were performed. Results: "Fast food" fed mice showed ocular pathology relevant to various stages of AMD including basal laminar deposits, focal thickening of Bruch's membrane, and a significant loss of RPE cells. Discussion/conclusion: A wild-type mouse model of metabolic syndrome fed a "fast food" diet developed changes to the retina similar to some of the pathologic features seen in AMD. Further investigations into this and similar animal models as well as further epidemiological studies are needed to more clearly define the association between metabolic syndrome and AMD.
C1 [Roddy, Gavin W.; Viker, Kimberly B.; Holman, Bradley H.; Hann, Cheryl R.; Bakri, Sophie J.; Fautsch, Michael P.] Mayo Clin, Dept Ophthalmol, 200 First St SW, Rochester, MN 55905 USA.
   [Rosa, Robert H., Jr.] Baylor Scott & White Eye Inst, Dept Ophthalmol, Temple, TX USA.
   [Krishnan, Anuradha; Gores, Gregory J.] Mayo Clin, Dept Gastroenterol, Rochester, MN USA.
C3 Mayo Clinic; Baylor Health Care System; Mayo Clinic
RP Roddy, GW (corresponding author), Mayo Clin, Dept Ophthalmol, 200 First St SW, Rochester, MN 55905 USA.
EM roddy.gavin@mayo.edu
FU National Eye Institute [EY 21727, EY26490]; Mayo Foundation, Rochester,
   MN; Liles Macular Degeneration Research Fund, Baylor Scott &
   White-Central Texas Foundation, Temple, TX; Center for Scientific Review
   [21727, 26490]
FX National Eye Institute grants [EY 21727 and EY26490]; Mayo Foundation,
   Rochester, MN; Liles Macular Degeneration Research Fund, Baylor Scott &
   White-Central Texas Foundation, Temple, TX; and Center for Scientific
   Review [21727, 26490].
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NR 65
TC 25
Z9 30
U1 0
U2 10
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 0271-3683
EI 1460-2202
J9 CURR EYE RES
JI Curr. Eye Res.
PD JUN 2
PY 2020
VL 45
IS 6
BP 726
EP 732
DI 10.1080/02713683.2019.1694156
EA NOV 2019
PG 7
WC Ophthalmology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Ophthalmology
GA LO5YY
UT WOS:000500101000001
PM 31735070
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Lindblad, BE
   Håkansson, N
   Wolk, A
AF Lindblad, Birgitta Ejdervik
   Hakansson, Niclas
   Wolk, Alicja
TI Metabolic syndrome and some of its components in relation to risk of
   cataract extraction. A prospective cohort study of men
SO ACTA OPHTHALMOLOGICA
LA English
DT Article
DE cataract; cohort studies; metabolic syndrome; risk factors
ID C-REACTIVE PROTEIN; AGE-RELATED CATARACT; LONG-TERM INCIDENCE;
   CARDIOVASCULAR-DISEASE; INFLAMMATORY MARKERS; OXIDATIVE STRESS; 5-YEAR
   INCIDENCE; CENTRAL OBESITY; LENS OPACITIES; HYPERTENSION
AB Purpose To evaluate the relationship between metabolic syndrome and some of its components with the incidence of cataract extraction. Methods A population-based prospective cohort with a total of 45 049 men, aged 45-79 years, from the Cohort of Swedish Men completed in 1997 a self-administered questionnaire concerning anthropometric measurements and lifestyle factors. The men were followed from 1 January 1998 through 31 December 2012, and the cohort was matched with registers of cataract extraction. The main outcome measure was incident cases of age-related cataract extraction. Results Over the 15-years of follow-up, 7573 incident cases of cataract extraction were identified. After controlling for potential confounders, the association between single components of metabolic syndrome, abdominal adiposity, diabetes and hypertension and risk of cataract extraction was rate ratio (RR): 1.04; 95% confidence interval (CI): 0.99-1.10, RR: 1.77; 95% CI: 1.64-1.92 and RR: 1.06; 95% CI 1.00-1.13, respectively. The risk of cataract extraction increased with increasing numbers of metabolic syndrome components (p < 0.0001). Men aged 65 years or younger at baseline with all three components of the metabolic syndrome had a relative risk of 2.43 (95% CI: 1.95-3.01) for cataract extraction. Conclusion In this cohort of middle-aged and elderly men, metabolic syndrome with the combination of abdominal adiposity, diabetes and hypertension was associated with an increased risk for cataract extraction, especially among men aged 65 years or younger. These findings put emphasis on the importance of weight control and healthy lifestyle behaviours in order to prevent cataract.
C1 [Lindblad, Birgitta Ejdervik] Orebro Univ, Sch Med Sci, Dept Ophthalmol, Orebro, Sweden.
   [Hakansson, Niclas; Wolk, Alicja] Karolinska Inst, Inst Environm Med, Stockholm, Sweden.
C3 Orebro University; Karolinska Institutet
RP Lindblad, BE (corresponding author), Orebro Univ Hosp, Dept Ophthalmol, SE-70185 Orebro, Sweden.
EM birgitta.ejdervik.lindblad@swipnet.se
RI Hakansson, Niclas/L-7913-2013
OI Hakansson, Niclas/0000-0001-7673-5554
FU Orebro County Council, Orebro, Sweden
FX This work was supported by research grants from Orebro County Council,
   Orebro, Sweden. There is no conflict of interest and the authors had no
   financial disclosures
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NR 40
TC 7
Z9 7
U1 0
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1755-375X
EI 1755-3768
J9 ACTA OPHTHALMOL
JI Acta Ophthalmol.
PD JUN
PY 2019
VL 97
IS 4
BP 409
EP 414
DI 10.1111/aos.13929
PG 6
WC Ophthalmology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Ophthalmology
GA HV7WE
UT WOS:000466191000009
PM 30353683
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Cheserek, MJ
   Wu, GR
   Shen, LY
   Shi, YH
   Le, GW
AF Cheserek, Maureen Jepkorir
   Wu, Guirong
   Shen, Liye
   Shi, Yonghui
   Le, Guowei
TI Evaluation of the relationship between subclinical hypothyroidism and
   metabolic syndrome components among workers
SO INTERNATIONAL JOURNAL OF OCCUPATIONAL MEDICINE AND ENVIRONMENTAL HEALTH
LA English
DT Article
DE Cardiovascular risks; Metabolic syndrome; Occupation; Subclinical
   hypothyroidism; Thyroid hormones; University workers
ID CORONARY-HEART-DISEASE; CARDIOVASCULAR-DISEASE; PHYSICAL-ACTIVITY;
   SEX-DIFFERENCES; RISK-FACTORS; PREVALENCE; ASSOCIATIONS; ALCOHOL;
   STRESS; ADULTS
AB Both hyperthyroidism and overt hypothyroidism are associated with increased prevalence of metabolic syndrome and its components, while data on subclinical hypothyroidism is currently limited especially in working populations. The aim of this study was to examine the association between subclinical hypothyroidism and metabolic syndrome components in workers; and to evaluate whether there are differences by sex and occupation.
   A total of 1150 university employees (male - 792, female - 358) aged 30-60 years who came for an annual medical check-up were studied. Anthropometric measurements were taken, and blood pressure, fasting plasma glucose (FPG), lipid profiles, thyroid stimulating hormone (TSH), free thyroxin (FT4) and free triiodothyronine (FT3) levels were measured.
   After adjustment for age and body mass index (BMI), TSH was positively associated with increased triglyceride (TG) levels (beta = 0.108, p = 0.020) and FPG (beta = 0.130, p = 0.006) in subclinical hypothyroid male workers. However, TSH was not associated (p > 0.05) with any component of metabolic syndrome (MS) in the euthyroid group. In females, TSH was not correlated with MS components in both euthyroid and subclinical hypothyroid groups. Furthermore, comparison by occupation showed higher TSH in subclinical hypothyroid male workers employed in administration (5.23 +/- 0.52 mU/l) than those working as academics (5.12 +/- 0.52 mU/l), which resulted in elevated systolic and diastolic blood pressure, FPG, total cholesterol, TG and high density lipoprotein cholesterol. In females, BMI, systolic and diastolic blood pressure, TG and FPG were significantly (p < 0.05) higher in subclinical hypothyroid administrators than those in academics.
   Subclinical hypothyroidism was associated with metabolic syndrome components in male workers and not in females. Administration workers showed increased metabolic risks compared to academics. The findings suggest that the assessment of thyroid function in individuals with metabolic syndrome in the workplace may be favorable especially among men.
C1 [Cheserek, Maureen Jepkorir; Shi, Yonghui; Le, Guowei] Jiangnan Univ, State Key Lab Food Sci & Technol, 1800 Lihu Rd, Wuxi 214122, Jiangsu, Peoples R China.
   [Cheserek, Maureen Jepkorir; Wu, Guirong; Shi, Yonghui; Le, Guowei] Jiangnan Univ, Mol & Appl Nutr Lab, Wuxi 214122, Jiangsu, Peoples R China.
   [Shen, Liye] Jiangnan Univ, Jiangnan Univ Hosp, Wuxi 214122, Jiangsu, Peoples R China.
   [Cheserek, Maureen Jepkorir] Egerton Univ, Dept Human Nutr, Njoro, Kenya.
C3 Jiangnan University; Jiangnan University; Jiangnan University; Egerton
   University
RP Le, GW (corresponding author), Jiangnan Univ, State Key Lab Food Sci & Technol, 1800 Lihu Rd, Wuxi 214122, Jiangsu, Peoples R China.
EM lgw@jiangnan.edu.cn
RI Cheserek, Maureen/AAD-6261-2022; SHI, YH/HLG-1159-2023
FU National Science and Technology Ministry of China;  [212BAD33B05]
FX Source of financial support: The project 212BAD33B05/metabolic syndrome
   and biomarkers. The National Science and Technology Ministry of China.
   Project manager: Guowei Le, Prof.
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NR 44
TC 12
Z9 12
U1 0
U2 12
PU NOFER INST OCCUPATIONAL MEDICINE, POLAND
PI LODZ
PA SW TERESY 8, LODZ, 91-348, POLAND
SN 1232-1087
EI 1896-494X
J9 INT J OCCUP MED ENV
JI Int. J. Occup. Med. Environ. Health
PD APR
PY 2014
VL 27
IS 2
BP 175
EP 187
DI 10.2478/s13382-014-0240-5
PG 13
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA AH6XM
UT WOS:000336275600004
PM 24619737
OA gold
DA 2025-06-11
ER

PT J
AU Lim, PS
   Chen, SL
   Wu, MY
   Hu, CY
   Wu, TK
AF Lim, Paik-Seong
   Chen, Shun-Liang
   Wu, Ming-Ying
   Hu, Chuen-Yuh
   Wu, Tsai-Kun
TI Association of plasma adiponectin levels with oxidative stress in
   Hemodialysis patients
SO BLOOD PURIFICATION
LA English
DT Article
DE adipocytes; adiponectin; atherosclerosis; metabolic syndrome; oxidative
   stress
ID ADIPOSE-SPECIFIC PROTEIN; METABOLIC RISK-FACTORS; INSULIN-RESISTANCE;
   RENAL-DISEASE; OBESITY; HYPOADIPONECTINEMIA; EXPRESSION;
   ATHEROSCLEROSIS; MALONDIALDEHYDE; ACCUMULATION
AB Background: Recent evidence suggests that oxidative stress may be an instigator of the metabolic syndrome, and adiponectin, an adipocyte- derived polypeptide, may modulate oxidative stress, ameliorating the atherosclerotic process. Aim: Oxidative stress is increased in hemodialysis ( HD) patients. We hypothesize that a relationship between plasma levels of adiponectin and markers of inflammation and oxidative stress exists. Methods and Results: In 124 HD patients, plasma adiponectin levels and three separate oxidative stress markers, tumor necrosis factor- alpha as well as high- sensitivity C- reactive protein ( hs CRP) were determined. Plasma adiponectin was significantly and negatively correlated with serum hs CRP ( r = - 0.247, p = 0.008) and plasma malondialdehyde ( MDA) levels ( r = - 0.326; p < 0.001). Multiple regression analyses suggested that plasma MDA, serum HDL cholesterol levels and logarithmically transformed hs CRP were the variables independently associated with plasma adiponectin levels. Conclusion: Plasma adiponectin was significantly associated with plasma MDA, serum HDL cholesterol levels and serum hs CRP levels. Our results suggest the possibility that plasma adiponectin may play a role in alleviating oxidative stress in HD patients. Copyright (c) 2007 S. Karger AG, Basel.
C1 Providence Univ, Dept Food Nutr, Taichung, Taiwan.
   Tung Taichung Metroharbor Hosp, Dept Clin Biochem, Taichung, Taiwan.
   Tung Taichung Metroharbor Hosp, Div Renal Med, Taichung, Taiwan.
C3 Providence University - Taiwan
RP Lim, PS (corresponding author), Lung Chin Hsiang, 31,Lane 80,Yi Shu N St, Taichung 433, Taiwan.
EM ps.lim@msa.hinet.net
RI Feng, yin/JQI-8627-2023
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NR 43
TC 12
Z9 13
U1 0
U2 3
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0253-5068
EI 1421-9735
J9 BLOOD PURIFICAT
JI Blood Purif.
PY 2007
VL 25
IS 4
BP 362
EP 369
DI 10.1159/000107509
PG 8
WC Hematology; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Hematology; Urology & Nephrology
GA 208KJ
UT WOS:000249317900062
PM 17709916
DA 2025-06-11
ER

PT J
AU Lin, JW
   Hwang, JJ
   Dai, DF
   Tseng, YZ
AF Lin, Jou-Wei
   Hwang, Juey-Jen
   Dai, Dao-Fu
   Tseng, Yung-Zu
TI Using structural equation model to illustrate the relationship between
   metabolic risk factors and cardiovascular complications in Taiwan
SO EUROPEAN JOURNAL OF CARDIOVASCULAR PREVENTION & REHABILITATION
LA English
DT Article
DE atherosclerosis; diabetes mellitus; metabolic syndrome X; statistical
   models; Taiwan
ID CORONARY-HEART-DISEASE; BLOOD-PRESSURE; MORTALITY; ATHEROSCLEROSIS;
   ASSOCIATION; PREVALENCE; DIAGNOSIS; SMOKING; ADULTS; HEALTH
AB Background The objective of this study was to perform a population-based screening programme to determine the prevalence of the metabolic syndrome (MetS) and the relationship between metabolic risk factors and prevalent cardiovascular complications in Taiwan.
   Design A screening programme recruited residents aged 40 years and older in Sanchih, Taipei County, Taiwan, and collected demographic data, blood and urine samples. Fasting plasma glucose level, serum total cholesterol, high-density lipoprotein cholesterol, and triglyceride were measured.. Atherosclerotic complications, including myocardial infarction, stress-positive angina, ischaemic stroke, and proteinuria were confirmed.
   Methods A structural equation model (SEM) was constructed to identify the association between metabolic abnormality and atherosclerosis.
   Results A total of 1494 subjects, 776 male and 718 female, were recruited in this study. The crude prevalence of the MetS was 19.3% for men [95% confidence interval (CI) 16.3-22.2%] and 18.7% for women (95% Cl 15.6-22.0%). The presence of the MetS posed a substantial risk to microvascular complications in both sexes [odds ratio (OR) 3.29, P < 0.001] and to macrovascular complications in men (OR 1.95, P = 0.04) and also a trend in women (OR 2.24, P = 0.089). There was a positive association between metabolic abnormality and atherosclerosis (B = 0.55, P < 0.001).
   Conclusions This study has found the prevalence of the MetS and the association with atherosclerotic complications in Taiwan. The SEM approach has demonstrated a positive correlation between metabolic abnormality and atherosclerosis and can be used to explore new risk factors for cardiovascular diseases.
C1 Natl Taiwan Univ Hosp, Dept Med, Cardiol Sect, Taipei 100, Taiwan.
   Natl Taiwan Univ Hosp, Yun Lin Branch, Yunlin, Taiwan.
C3 National Taiwan University; National Taiwan University Hospital;
   National Taiwan University; National Taiwan University Hospital
RP Tseng, YZ (corresponding author), Natl Taiwan Univ Hosp, Dept Med, Cardiol Sect, 7 Chung San S Rd,Sec 1, Taipei 100, Taiwan.
EM yztseng@ha.mc.ntu.edu.tw
RI Dai, Dao-Fu/AAM-4396-2021; Zhang, Zhenyu/GZL-8479-2022
OI Dai, Dao-Fu/0000-0001-7724-321X; Hwang, Juey-Jen/0000-0001-6437-0455
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NR 32
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U1 0
U2 6
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1741-8267
EI 1741-8275
J9 EUR J CARDIOV PREV R
JI Eur. J. Cardiovasc. Prev. Rehabil.
PD AUG
PY 2006
VL 13
IS 4
BP 633
EP 639
DI 10.1097/01.hjr.0000230095.65062.a9
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 081AG
UT WOS:000240289000023
PM 16874156
DA 2025-06-11
ER

PT J
AU Singleton, JR
   Foster-Palmer, S
   Marcus, RL
AF Singleton, J. Robinson
   Foster-Palmer, Stormy
   Marcus, Robin L.
TI Exercise as Treatment for Neuropathy in the Setting of Diabetes and
   Pre-diabetic Metabolic Syndrome: A Review of Animal Models and Human
   Trials
SO CURRENT DIABETES REVIEWS
LA English
DT Review
ID CARDIAC AUTONOMIC NEUROPATHY; IMPAIRED GLUCOSE-TOLERANCE; GLYCATION
   END-PRODUCTS; LIFE-STYLE INTERVENTION; NUTRITION EXAMINATION SURVEY;
   ADIPOSE-TISSUE INFLAMMATION; ALDOSE REDUCTASE INHIBITOR; EARLY NERVE
   REGENERATION; FAST AXONAL-TRANSPORT; DIET-INDUCED-OBESITY
AB Background: Peripheral neuropathy is among the most common complications of diabetes, but a phenotypically identical distal sensory predominant, painful axonopathy afflicts patients with prediabetic metabolic syndrome, exemplifying a spectrum of risk and continuity of pathogenesis. No pharmacological treatment convincingly improves neuropathy in the setting of metabolic syndrome, but evolving data suggest that exercise may be a promising alternative.
   Objective: The aim of the study was to review in depth the current literature regarding exercise treatment of metabolic syndrome neuropathy in humans and animal models, highlight the diverse mechanisms by which exercise exerts beneficial effects, and examine adherence limitations, safety aspects, modes and dose of exercise.
   Results: Rodent models that recapitulate the organismal milieu of prediabetic metabolic syndrome and the phenotype of its neuropathy provide a strong platform to dissect exercise effects on neuropathy pathogenesis. In these models, exercise reverses hyperglycemia and consequent oxidative and nitrosative stress, improves microvascular vasoreactivity, enhances axonal transport, ameliorates the lipotoxicity and inflammatory effects of hyperlipidemia and obesity, supports neuronal survival and regeneration following injury, and enhances mitochondrial bioenergetics at the distal axon. Prospective human studies are limited in scale but suggest exercise to improve cutaneous nerve regenerative capacity, neuropathic pain, and task-specific functional performance measures of gait and balance. Like other heath behavioral interventions, the benefits of exercise are limited by patient adherence.
   Conclusion: Exercise is an integrative therapy that potently reduces cellular inflammatory state and improves distal axonal oxidative metabolism to ameliorate features of neuropathy in metabolic syndrome. The intensity of exercise need not improve cardinal features of metabolic syndrome, including weight, glucose control, to exert beneficial effects.
C1 [Singleton, J. Robinson; Foster-Palmer, Stormy] Univ Utah, Dept Neurol, Salt Lake City, UT 84112 USA.
   [Marcus, Robin L.] Univ Utah, Dept Phys Therapy & Athlet Training, Salt Lake City, UT USA.
C3 Utah System of Higher Education; University of Utah; Utah System of
   Higher Education; University of Utah
RP Singleton, JR (corresponding author), Univ Utah, Dept Neurol, Salt Lake City, UT 84112 USA.
EM rob.singleton@hsc.utah.edu
OI Singleton, John R./0000-0002-6456-0045
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NR 313
TC 7
Z9 8
U1 1
U2 12
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1573-3998
EI 1875-6417
J9 CURR DIABETES REV
JI Curr. Diabetes Reviews
PY 2022
VL 18
IS 5
AR e230921196752
DI 10.2174/1573399817666210923125832
PG 33
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA 3M1JQ
UT WOS:000835214500008
PM 34561989
DA 2025-06-11
ER

PT J
AU Owlasiuk, A
   Chlabicz, S
   Gryko, A
   Litwiejko, A
   Malyszko, J
   Bielska, D
AF Owlasiuk, Anna
   Chlabicz, Slawomir
   Gryko, Anna
   Litwiejko, Alicja
   Malyszko, Jolanta
   Bielska, Dorota
TI Pedometer assessed physical activity of people with metabolic syndrome
   in Poland
SO ANNALS OF AGRICULTURAL AND ENVIRONMENTAL MEDICINE
LA English
DT Article
DE physical activity; activity type; pedometer; metabolic syndrome
ID AMBULATORY ACTIVITY; ADULTS; HEALTH; QUESTIONNAIRE; PATTERNS; STEPS;
   WOMEN
AB Introduction. Metabolic syndrome is a contemporary disease of civilization, an effect of lack of healthy behaviour, a consequence of lifestyle devoid of physical activity, eating poor quality food rich in calories and excessive stress. Apart from a proper diet, physical activity remains an important part of metabolic syndrome management.
   Objective. The main objective of the work was to evaluate the physical activity of an adult population of patients with metabolic syndrome.
   Materials and method. Adults aged 35-70 fulfilling the criteria of metabolic syndrome according to International Diabetes Federation (IDF) were included. New Lifestyles NL-2000 pedometers were used to assess locomotive physical activity during an entire week.
   Results. In the group of 100 subjects, as many as 61 people (61%) represented low or sedentary activity, while nearly one fourth of the respondents - 23 (32%) represented the negligible activity type. Average weekly physical activity of those in the study was 6,743 steps/day (in 100 individuals) and ranged from 1,781-15,169. A great diversity was found in the study group, since the highest number of steps per day was 23,347 and the lowest -409. No significant differences in the number of steps on weekdays and at weekends were observed (mean:6,676/day and 6,913/day, respectively). A statistically significant negative correlation (r = -0.29) was observed between age and physical activity, between the average daily number of steps in the week and Waist Hip Ratio (WHR) (r = 0.201), as well as between the average daily number of steps in the week and Body Mass Index (BMI) (r = 0.226).
   Conclusions. The majority of people with metabolic syndrome represent a low or sedentary activity type and decrease of physical activity corresponds to increasing age, BMI and WHR. No significant differences in physical activity are observed between working days and free days (weekends).
C1 [Owlasiuk, Anna; Chlabicz, Slawomir; Gryko, Anna; Litwiejko, Alicja; Bielska, Dorota] Med Univ, Dept Family Med & Community Nursing, PL-15054 Bialystok, Poland.
   [Malyszko, Jolanta] Med Univ, Dept Hypertens & Nephrol, Dialysis Unit, PL-15054 Bialystok, Poland.
C3 Medical University of Bialystok; Medical University of Bialystok
RP Chlabicz, S (corresponding author), Med Univ, Dept Family Med & Community Nursing, Mieszka 1 4B, PL-15054 Bialystok, Poland.
EM schlabicz@poczta.onet.pl
RI Malyszko, Jolanta/GSM-7177-2022; Malyszko, Jolanta/M-7295-2018; Gryko,
   Anna/T-4099-2018; Bielska, Dorota/U-3090-2018
OI Malyszko, Jolanta/0000-0001-8701-8171; Gryko, Anna/0000-0001-7534-0243;
   Chlabicz, Slawomir/0000-0001-5022-4588; Bielska,
   Dorota/0000-0002-5117-468X
FU Medical University of Bialystok, Poland
FX The study was funded by a Grant from the Medical University of
   Bialystok, Poland.
CR [Anonymous], 2001, CZYNNIKI RYZYKA
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NR 29
TC 5
Z9 6
U1 0
U2 13
PU INST AGRICULTURAL MEDICINE
PI LUBLIN
PA JACZEWSKIEGO 2, PO BOX 185, 20-950 LUBLIN, POLAND
SN 1232-1966
EI 1898-2263
J9 ANN AGR ENV MED
JI Ann. Agr. Env. Med.
PY 2014
VL 21
IS 2
BP 353
EP 358
DI 10.5604/1232-1966.1108604
PG 6
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA AK7JE
UT WOS:000338603800025
PM 24959789
OA Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Nguyen, HD
   Oh, H
   Hoang, NHM
   Jo, WH
   Kim, MS
AF Nguyen, Hai Duc
   Oh, Hojin
   Hoang, Ngoc Hong Minh
   Jo, Won Hee
   Kim, Min-Sun
TI Environmental science and pollution research role of heavy metal
   concentrations and vitamin intake from food in depression: a national
   cross-sectional study (2009-2017)
SO ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
LA English
DT Article
DE Heavy metals; Depression; Cadmium; Food intakes
ID OXIDATIVE STRESS; METABOLIC SYNDROME; BLOOD CADMIUM; SEROTONIN
   METABOLISM; MERCURY LEVELS; LEAD LEVELS; THIAMINE; HEALTH; ASSOCIATION;
   SYMPTOMS
AB Little is known about associations between depression and serum heavy metal levels, dietary vitamin intakes. Thus, we sought to determine the nature of these associations and to predict risks of depression using marginal effects. A data set of 16,371 individuals aged >= 10 years that participated in Korea National Health and Nutrition Examination Surveys (KNHANES) conducted from 2009 to 2017 (excluding 2014 and 2015) was used to obtain information on sociodemographics, family histories. lifestyles, serum heavy metal levels, food intakes, and depression. Serum cadmium (Cd) and lead (Pb) levels were analyzed by graphite furnace atomic absorption spectrometry and mercury (Hg) levels using a mercury analyzer. Daily vitamin intakes were calculated by 24-h dietary recall. The results obtained showed that females are at higher risk of depression than males. A doubling of serum Cd was associated with a 21% increase in depression (AOR 1.21, 95% CI: 1.07-1.37, p = 0.002), whereas twofold increases in daily vitamin B1, B3 and vitamin A intakes reduced the risk of depression by 17% (0.83, 95% CI: 0.73-0.95, p = 0.005), 20% (0.80, 95% CI: 0.70-0.91, p = 0.001), and 8% (0.92, 95% CI: 0.85-0.99, p = 0.020), respectively. Interactions between heavy metals, vitamin intakes, and sex did not influence the risk of depression. The result shows that increased daily dietary vitamin intake might protect the public against depression. Further studies are needed to reduce the risks posed by heavy metals and to determine more comprehensively the effects of daily dietary vitamin intake on depression.
C1 [Nguyen, Hai Duc; Oh, Hojin; Hoang, Ngoc Hong Minh; Jo, Won Hee; Kim, Min-Sun] Sunchon Natl Univ, Coll Pharm, Dept Pharm, Sunchon 57922, Jeonnam, South Korea.
   [Nguyen, Hai Duc; Oh, Hojin; Hoang, Ngoc Hong Minh; Jo, Won Hee; Kim, Min-Sun] Sunchon Natl Univ, Res Inst Life & Pharmaceut Sci, Sunchon 57922, Jeonnam, South Korea.
C3 Sunchon National University; Sunchon National University
RP Kim, MS (corresponding author), Sunchon Natl Univ, Coll Pharm, Dept Pharm, Sunchon 57922, Jeonnam, South Korea.; Kim, MS (corresponding author), Sunchon Natl Univ, Res Inst Life & Pharmaceut Sci, Sunchon 57922, Jeonnam, South Korea.
EM minsun@scnu.ac.kr
RI Oh, Hojin/ABA-7781-2021; Hoang, Ngoc/R-2353-2017; Nguyen Duc,
   Hai/AAD-8210-2020
OI Nguyen Duc, Hai/0000-0001-8419-7784; Kim, Min-Sun/0000-0001-9952-0038;
   Oh, Hojin/0000-0002-4022-5998
FU National Research Foundation of Korea (NRF) - Korea government (MEST)
   [NRF2013R1A1A3008851, 2018R1D1A1B07049610]
FX This work was supported by National Research Foundation of Korea (NRF)
   grant funded by the Korea government (MEST) (grant nos.
   NRF2013R1A1A3008851 and 2018R1D1A1B07049610).
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NR 85
TC 53
Z9 53
U1 6
U2 34
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0944-1344
EI 1614-7499
J9 ENVIRON SCI POLLUT R
JI Environ. Sci. Pollut. Res.
PD JAN
PY 2022
VL 29
IS 3
BP 4574
EP 4586
DI 10.1007/s11356-021-15986-w
EA AUG 2021
PG 13
WC Environmental Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology
GA YD3SB
UT WOS:000686447400012
PM 34414543
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Garbarino, S
   Magnavita, N
AF Garbarino, Sergio
   Magnavita, Nicola
TI Work Stress and Metabolic Syndrome in Police Officers. A Prospective
   Study
SO PLOS ONE
LA English
DT Article
ID EFFORT-REWARD IMBALANCE; CORONARY-HEART-DISEASE; JOB DEMAND-CONTROL;
   CARDIOVASCULAR-DISEASE; PSYCHOMETRIC PROPERTIES; OCCUPATIONAL STRESS;
   DECISION LATITUDE; PERCEIVED STRESS; OXIDATIVE STRESS; LIFE-STYLE
AB Objective
   The aim of this longitudinal study was to evaluate the association between occupational stress and metabolic syndrome (MetS) in a rapid response police unit.
   Method
   Work-related stress was continuously monitored during the 5-year period with both the Demand-Control-Support (DCS) and the Effort-Reward Imbalance (ERI) models. Blood pressure, body mass index (BMI), waist circumference, triglycerides, HDL-cholesterol, and fasting blood glucose were measured at baseline in January 2009, and in January 2014. 234 out of 290 police officers (81%) completed the follow-up.
   Results
   The majority of police officers had high stress levels. At follow-up, police officers in the highest quartile of stress had significantly higher mean levels of triglycerides, and lower levels of HDL-cholesterol than their colleagues in the lowest quartile. Police officers with high stress had an increased adjusted risk of developing MetS (aOR = 2.68; CI95%= 1.08-6.70), and hypertriglyceridemia (aOR = 7.86; CI95 = 1.29-48.04). Demand and Effort were significant predictors of MetS.
   Conclusion
   Our study supports the hypothesis that work-related stress induces MetS, particularly through its effects on blood lipids. Future longitudinal studies with continuous monitoring of stress levels will definitively confirm this hypothesis.
C1 [Garbarino, Sergio] Minist Interior, State Police Hlth Serv Dept, Genoa, Italy.
   [Garbarino, Sergio] Univ Genoa, Dept Hlth Sci, Genoa, Italy.
   [Garbarino, Sergio] Dept Neurosci Rehabil Ophthalmol Genet & Maternal, Genoa, Italy.
   [Magnavita, Nicola] Univ Cattolica Sacro Cuore, Dept Publ Hlth, Rome, Italy.
C3 University of Genoa; Catholic University of the Sacred Heart; IRCCS
   Policlinico Gemelli
RP Magnavita, N (corresponding author), Univ Cattolica Sacro Cuore, Dept Publ Hlth, Rome, Italy.
EM nicolamagnavita@gmail.com
RI Magnavita, Nicola/J-6074-2014; Garbarino, Sergio/X-5368-2018
OI Garbarino, Sergio/0000-0002-8508-552X
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NR 83
TC 106
Z9 124
U1 0
U2 23
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD DEC 7
PY 2015
VL 10
IS 12
AR e0144318
DI 10.1371/journal.pone.0144318
PG 15
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA CZ1YS
UT WOS:000366902700097
PM 26641879
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Smith, JP
   Haddad, EV
   Taylor, MB
   Oram, D
   Blakemore, D
   Chen, QX
   Boutaud, O
   Oates, JA
AF Smith, James P.
   Haddad, Elias V.
   Taylor, Mary B.
   Oram, Denise
   Blakemore, Dana
   Chen, Qingxia
   Boutaud, Olivier
   Oates, John A.
TI Suboptimal Inhibition of Platelet Cyclooxygenase-1 by Aspirin in
   Metabolic Syndrome
SO HYPERTENSION
LA English
DT Article
DE aspirin; thromboxane; platelets; coronary disease; metabolic syndrome
ID LOW-DOSE ASPIRIN; THROMBOXANE BIOSYNTHESIS; CARDIOVASCULAR EVENTS;
   PRIMARY PREVENTION; DIABETES-MELLITUS; OXIDATIVE STRESS; RISK-FACTORS;
   RESISTANCE; ACTIVATION; PROSTACYCLIN
AB Interindividual variation in the ability of aspirin to inhibit platelet cyclooxygenase-1 (COX-1) could account for some on-treatment cardiovascular events. Here, we sought to determine whether there are clinical phenotypes that are associated with a suboptimal pharmacological effect of aspirin. In a prospective, 2-week study, we evaluated the effect of aspirin (81 mg) on platelet COX-1 in 135 patients with stable coronary artery disease by measuring serum thromboxane B-2 (sTxB(2)) as an indicator of inhibition of platelet COX-1. A nested randomized study compared enteric-coated with immediate-release formulations of aspirin. We found that sTxB(2) was systematically higher among the 83 patients with metabolic syndrome than among the 52 patients without (median: 4.0 versus 3.02 ng/mL; P = 0.013). Twelve patients (14%) with metabolic syndrome, but none without metabolic syndrome, had sTxB(2) levels consistent with inadequate inhibition of COX (sTxB(2) >= 13 ng/mL). In linear regression models, metabolic syndrome (but none of its individual components) significantly associated with higher levels of log-transformed sTxB(2) (P = 0.006). Higher levels of sTxB(2) associated with greater residual platelet function measured by aggregometry-based methods. Among the randomized subset, sTxB(2) levels were systematically higher among patients receiving enteric-coated aspirin. Last, urinary 11-dehydrothromboxane B-2 did not correlate with sTxB(2), suggesting that the former should not be used to quantitate aspirin's pharmacological effect on platelets. In conclusion, metabolic syndrome, which places patients at high risk for thrombotic cardiovascular events, strongly and uniquely associates with less effective inhibition of platelet COX-1 by aspirin. (Hypertension. 2012; 59: 719-725.). Online Data Supplement
C1 [Smith, James P.; Haddad, Elias V.; Oram, Denise; Oates, John A.] Vanderbilt Univ, Ctr Med, Dept Med, Nashville, TN 37232 USA.
   [Taylor, Mary B.] Vanderbilt Univ, Ctr Med, Dept Pediat, Nashville, TN 37232 USA.
   [Boutaud, Olivier; Oates, John A.] Vanderbilt Univ, Ctr Med, Dept Pharmacol, Nashville, TN 37232 USA.
   [Blakemore, Dana; Chen, Qingxia] Vanderbilt Univ, Ctr Med, Dept Biostat, Nashville, TN 37232 USA.
C3 Vanderbilt University; Vanderbilt University; Vanderbilt University;
   Vanderbilt University
RP Oates, JA (corresponding author), 536 Robinson Res Bldg,2222 Pierce Ave, Nashville, TN 37232 USA.
EM john.oates@vanderbilt.edu
RI Boutaud, Olivier/JVP-2991-2024
FU Specialized Centers of Clinically Oriented Research in Hemostatic and
   Thrombotic Diseases [P50HL81009]; Vanderbilt Clinical and Translational
   Science Award [UL1RR024975]; McNeil Pharmaceuticals;  [T32DK007569]; 
   [5T32GM07569]
FX This project was supported by the Specialized Centers of Clinically
   Oriented Research in Hemostatic and Thrombotic Diseases (P50HL81009),
   the Vanderbilt Clinical and Translational Science Award (UL1RR024975), a
   grant from McNeil Pharmaceuticals, and grants T32DK007569 (J.P.S.) and
   5T32GM07569 (J.P.S. and E. V. H.). J.A.O. is the Thomas F. Frist, Sr,
   Professor of Medicine.
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NR 46
TC 34
Z9 35
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0194-911X
EI 1524-4563
J9 HYPERTENSION
JI Hypertension
PD MAR
PY 2012
VL 59
IS 3
BP 719
EP U405
DI 10.1161/HYPERTENSIONAHA.111.181404
PG 13
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 911KF
UT WOS:000301715000038
PM 22311905
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Bender, SB
   DeMarco, VG
   Padilla, J
   Jenkins, NT
   Habibi, J
   Garro, M
   Pulakat, L
   Aroor, AR
   Jaffe, IZ
   Sowers, JR
AF Bender, Shawn B.
   DeMarco, Vincent G.
   Padilla, Jaume
   Jenkins, Nathan T.
   Habibi, Javad
   Garro, Mona
   Pulakat, Lakshmi
   Aroor, Annayya R.
   Jaffe, Iris Z.
   Sowers, James R.
TI Mineralocorticoid Receptor Antagonism Treats Obesity-Associated Cardiac
   Diastolic Dysfunction
SO HYPERTENSION
LA English
DT Article
DE aldosterone; echocardiography; immune marker; metabolic syndrome X
ID PRESERVED EJECTION FRACTION; LEFT-VENTRICULAR DYSFUNCTION;
   HEART-FAILURE; INSULIN-RESISTANCE; ENDOTHELIAL DYSFUNCTION; ZUCKER
   OBESE; MYOCARDIAL-INFARCTION; VASCULAR DYSFUNCTION; METABOLIC SYNDROME;
   DIABETES-MELLITUS
AB Patients with obesity and diabetes mellitus exhibit a high prevalence of cardiac diastolic dysfunction (DD), an independent predictor of cardiovascular events for which no evidence-based treatment exists. In light of renin-angiotensin-aldosterone system activation in obesity and the cardioprotective action of mineralocorticoid receptor (MR) antagonists in systolic heart failure, we examined the hypothesis that MR blockade with a blood pressure independent low-dose spironolactone (LSp) would treat obesity-associated DD in the Zucker obese (ZO) rat. Treatment of ZO rats exhibiting established DD with LSp normalized cardiac diastolic function, assessed by echocardiography. This was associated with reduced cardiac fibrosis, but not reduced hypertrophy, and restoration of endothelium-dependent vasodilation of isolated coronary arterioles via a nitric oxide independent mechanism. Further mechanistic studies revealed that LSp reduced cardiac oxidative stress and improved endothelial insulin signaling, with no change in arteriolar stiffness. Infusion of Sprague-Dawley rats with the MR agonist aldosterone reproduced the DD noted in ZO rats, In addition, improved cardiac function in ZO-LSp rats was associated with attenuated systemic and adipose inflammation and an anti-inflammatory shift in cardiac immune cell mRNAs. Specifically, LSp increased cardiac markers of alternatively activated macrophages and regulatory T cells. ZO-LSp rats had unchanged blood pressure, serum potassium, systemic insulin sensitivity, or obesity-associated kidney injury, assessed by proteinuria. Taken together, these data demonstrate that MR antagonism effectively treats established obesity-related DD via blood pressure independent mechanisms. These findings help identify a particular population with DD that might benefit from MR antagonist therapy, specifically patients with obesity and insulin resistance,
C1 [Bender, Shawn B.; DeMarco, Vincent G.; Habibi, Javad; Garro, Mona; Pulakat, Lakshmi; Aroor, Annayya R.; Sowers, James R.] Harry S Truman Mem Vet Hosp, Res Serv, Columbia, MO 65201 USA.
   [Bender, Shawn B.] Univ Missouri, Dept Biomed Sci, Columbia, MO 65211 USA.
   [Bender, Shawn B.; Padilla, Jaume; Sowers, James R.] Univ Missouri, Dalton Cardiovasc Res Ctr, Columbia, MO 65211 USA.
   [Padilla, Jaume] Univ Missouri, Dept Nutr & Exercise Physiol, Columbia, MO 65211 USA.
   [DeMarco, Vincent G.; Habibi, Javad; Garro, Mona; Aroor, Annayya R.; Sowers, James R.] Univ Missouri, Sch Med, Dept Med, Div Endocrinol Diabet & Metab, Columbia, MO 65211 USA.
   [Pulakat, Lakshmi] Univ Missouri, Sch Med, Dept Med, Div Cardiovasc Med, Columbia, MO 65211 USA.
   [DeMarco, Vincent G.; Pulakat, Lakshmi; Sowers, James R.] Univ Missouri, Sch Med, Dept Med Pharmacol & Physiol, Columbia, MO 65211 USA.
   [Padilla, Jaume] Univ Missouri, Sch Med, Dept Child Hlth, Columbia, MO 65211 USA.
   [Jenkins, Nathan T.] Univ Georgia, Dept Kinesiol, Athens, GA 30602 USA.
   [Jaffe, Iris Z.] Tufts Med Ctr, Mol Cardiol Res Inst, Boston, MA USA.
C3 US Department of Veterans Affairs; Veterans Health Administration (VHA);
   Harry S. Truman Memorial Veterans' Hospital; University of Missouri
   System; University of Missouri Columbia; University of Missouri System;
   University of Missouri Columbia; University of Missouri System;
   University of Missouri Columbia; University of Missouri System;
   University of Missouri Columbia; University of Missouri System;
   University of Missouri Columbia; University of Missouri System;
   University of Missouri Columbia; University of Missouri System;
   University of Missouri Columbia; University System of Georgia;
   University of Georgia; Tufts Medical Center
RP Bender, SB (corresponding author), Univ Missouri, Dept Biomed Sci, E102 Vet Mod Bldg, Columbia, MO 65211 USA.
EM benders@missouri.edu
FU Department of Veterans Affairs Biomedical Laboratory Research
   Development [CDA-2 IK2 BX002030, 0018]; Missouri Foundation for Medical
   Research; National Institutes of Health [HL073101, HL107910,
   K01HL125503]; University of Missouri Life Science Mission Enhancement
   Fund
FX Supported by Department of Veterans Affairs Biomedical Laboratory
   Research & Development (CDA-2 IK2 BX002030 to Dr Bender, 0018 to Dr
   Sowers), Missouri Foundation for Medical Research (to Dr Bender),
   National Institutes of Health (HL073101, HL107910 to Dr Sowers;
   K01HL125503 to Dr Padilla), and University of Missouri Life Science
   Mission Enhancement Fund (Dr Pulakat). This work was supported with
   resources and the use of facilities at the Harry S. Truman Memorial
   Veterans Hospital in Columbia, MO.
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NR 43
TC 85
Z9 88
U1 0
U2 8
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0194-911X
EI 1524-4563
J9 HYPERTENSION
JI Hypertension
PD MAY
PY 2015
VL 65
IS 5
BP 1082
EP U774
DI 10.1161/HYPERTENSIONAHA.114.04912
PG 24
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA CF4AJ
UT WOS:000352490400104
PM 25712719
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Xu, L
   Yang, Y
   Li, B
   Liu, HD
   Xu, LX
   Yan, DM
   Gao, XM
AF Xu, Lin
   Yang, Yue
   Li, Bin
   Liu, Hong Dong
   Xu, Ling Xia
   Yan, Dong Mei
   Gao, Xue Mei
TI Exploring the therapeutic potential of Cassia species on metabolic
   syndrome: A comprehensive review
SO SOUTH AFRICAN JOURNAL OF BOTANY
LA English
DT Review
DE Cassia; Lipid metabolism; Metabolic syndrome; Anti-hyperlipidemia;
   Anti-obesity; Anti-diabetes
ID LEGUMINOSAE SEED EXTRACT; ANTIDIABETIC ACTIVITY; ALPHA-GLUCOSIDASE;
   OXIDATIVE STRESS; FISTULA LINN.; BLOOD-GLUCOSE; LEAF EXTRACT; STEM BARK;
   ANTIHYPERLIPIDEMIC ACTIVITY; HYPOLIPIDEMIC ACTIVITY
AB Background: In tropical and subtropical region, Cassia (Fabaceae) is widely distributed, and many species of this genus are used for medicinal purposes such as hypertension, hyperlipidemia, obesity, diabetes in China and India. However, there are limited reviews describing the biological activity on metabolic syndrome associated with Cassia species. Methods: Online databases including SciFinder, Web of Science, PubMed, Science Direct, ACS Journals, Springer, Tailor & Francis, Wiley, The Plant List Database, Google Scholar, and China National Knowledge Infrastructure (CNKI), were consulted by using "Cassia",(Cassia)", "Senna", "ethnobotany", "traditional use", "ethnomedicine", "phytochemistry", "Lipid Metabolism", "metabolic syndrome", "anti-obesity", "anti-diabetes" and "anti- hyperlipidemia" as keywords. Results: Extracts, a total of 23 non-volatile natural products and one peptide from 18 Cassia species have demonstrated efficacy in treating metabolic syndrome and related complications. Sixty-five commercial Chinese polyherbal preparation with ingredients of Cassia seeds or Senna leaves showed effects on MetS. Conclusions: This review presents an in-depth analysis of the chemical constituents and medicinal properties of the ethnomedicinally important Cassia species on metabolic syndrome and related complications such as hyperlipidemia, obesity and diabetes etc. Overall, most publications focused on species of C. angustifolia, C. auriculate, C. fistula, C. glauca, and C. obtusifolia. It is not fully understood how chemical compounds interact with the corresponding target proteins. In spite of this, preliminary data from other Cassia species indicate the potential of this genus for research on metabolic syndrome, both phytochemically, pharmacologically and clinical uses of C. species. (c) 2024 SAAB. Published by Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.
C1 [Xu, Lin; Yang, Yue; Li, Bin; Liu, Hong Dong; Xu, Ling Xia; Yan, Dong Mei; Gao, Xue Mei] Jiangxi Univ Chinese Med, Academician Workstn, Nanchang 330004, Jiangxi, Peoples R China.
C3 Jiangxi University of Traditional Chinese Medicine
RP Gao, XM (corresponding author), Jiangxi Univ Chinese Med, Academician Workstn, Nanchang 330004, Jiangxi, Peoples R China.
EM gao_xuemei@hotmail.com
RI Gao, Xuemei/HQY-8663-2023; Liu, Hongdong/AAG-4353-2020
OI Gao, Xue Mei/0000-0002-4338-0707
FU PhD research startup foundation of Jiangxi University of Chinese
   Medicine [2021BSZR002]; Jiangxi University of Chinese Medicine Science
   and Technology Innovation Team Development Program [CXTD22010]; National
   Natural Science Foundation of China [21362044, 21562046]
FX This work was supported by the PhD research startup foundation of
   Jiangxi University of Chinese Medicine [Grant number 2021BSZR002] ,
   Jiangxi University of Chinese Medicine Science and Technology Innovation
   Team Development Program [Grant number CXTD22010] , National Natural
   Science Foundation of China [Grant number 21362044 and 21562046] .
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NR 141
TC 1
Z9 1
U1 4
U2 8
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0254-6299
EI 1727-9321
J9 S AFR J BOT
JI S. Afr. J. Bot.
PD OCT
PY 2024
VL 173
BP 112
EP 136
DI 10.1016/j.sajb.2024.07.067
EA AUG 2024
PG 25
WC Plant Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences
GA E1J7M
UT WOS:001300646300001
DA 2025-06-11
ER

PT J
AU Franks, PW
   Ekelund, U
   Brage, S
   Wong, MY
   Wareham, NJ
AF Franks, PW
   Ekelund, U
   Brage, S
   Wong, MY
   Wareham, NJ
TI Does the association of habitual physical activity with the metabolic
   syndrome differ by level of cardiorespiratory fitness?
SO DIABETES CARE
LA English
DT Article
ID MIDDLE-AGED MEN; ENERGY-EXPENDITURE; DIABETES-MELLITUS; LEISURE-TIME;
   HERITAGE FAMILY; EUROPEAN-UNION; HUMAN GENE; WEIGHT; PERFORMANCE;
   CALORIMETRY
AB OBJECTIVE - Cardiovascular fitness (VO2max) and physical activity arc both related to risk of Metabolic disease. It is unclear, however, whether the metabolic effects of sedentary living are the same in fit and unfit individuals. The purpose of this study was, therefore, to describe the association between physical activity and the metabolic syndrome and to test whether fitness level modifies this relationship.
   RESEARCH DESIGN AND METHODS - physical activity Was measured objectively using individually calibrated heart rate against energy expenditure. VO2max was predicted front a submaximal exercise stress test. Fat mass and fat-free mass (FFM) were calculated using impedance biometry. A metabolic syndrome score was computed by summing the standardized values for obesity, hypertension, hyperglycemia, insulin resistance, hypertriglyceridemia, and the inverse level of HDL cholesterol and was expressed as a continuously distributed Outcome. To correct for exposure measurement cri-or, a random subsample (22% of cohort) re-attended for three repeat measurements in the year following the first assessment.
   RESULTS - The relationship of VO2max (ml O-2 (.) kg(FFM)(-1) (.) min(-1)) and the metabolic syndrome score was of borderline significance after adjusting for age, sex, physical activity, and measurement error (beta = -0.58, P = 0.06). The magnitude of the association between physical activity (kJ (.) d(-1) (.) kg(FFM)(-1)) and the metabolic syndrome was more than three tunes greater than for VO(2ma)x (standardized beta = - 1,83, P = 0.0042). VO2max however, modified the relationship between physical activity energy expenditure and metabolic syndrome (P = 0 036).
   CONCLUSIONS - This study demonstrates a Strong inverse association between physical activity and metabolic syndrome, an association that is much steeper in unfit individuals. Thus, prevention of metabolic disease may be most effective In the subset of unfit inactive people.
C1 MRC, Epidemiol Unit, Cambridge, England.
   Hong Kong Univ Sci & Technol, Dept Math, Hong Kong, Hong Kong, Peoples R China.
C3 Hong Kong University of Science & Technology
RP NIDDK, Diabet & Arthrit Epidemiol Sect, NIH, 4881 E Indian Sch Rd, Phoenix, AZ 85014 USA.
EM pfranks@niddk.nih.gov
RI Franks, Paul/AAA-3300-2020; Timpson, Nicholas/O-7548-2015; Ekelund,
   Ulf/A-1046-2008; Brage, Soren/C-6415-2013
OI Brage, Soren/0000-0002-1265-7355; Franks, Paul/0000-0002-0520-7604
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NR 48
TC 155
Z9 183
U1 0
U2 14
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0149-5992
EI 1935-5548
J9 DIABETES CARE
JI Diabetes Care
PD MAY
PY 2004
VL 27
IS 5
BP 1187
EP 1193
DI 10.2337/diacare.27.5.1187
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 817DB
UT WOS:000221157100030
PM 15111543
OA Bronze
DA 2025-06-11
ER

PT J
AU Cooney, LG
   Dokras, A
AF Cooney, Laura G.
   Dokras, Anuja
TI Beyond fertility: polycystic ovary syndrome and long-term health
SO FERTILITY AND STERILITY
LA English
DT Review
DE PCOS; menopause; aging; diabetes; cardiovascular disease
ID OBSTRUCTIVE SLEEP-APNEA; INTIMA-MEDIA THICKNESS; CORONARY-ARTERY
   CALCIFICATION; IMPAIRED GLUCOSE-TOLERANCE; FATTY LIVER-DISEASE;
   MIDDLE-AGED WOMEN; FOLLOW-UP; CARDIOVASCULAR-DISEASE; METABOLIC
   SYNDROME; DIABETES-MELLITUS
AB Polycystic ovary syndrome (PCOS) is a reproductive, endocrine, and metabolic disorder affecting millions of women worldwide. Women with PCOS are often identified in adolescence or early adulthood with symptoms of oligomenorrhea or hirsutism or when presenting for infertility care. The health risks associated out of PCOS, however, go far beyond management of these common presenting symptoms or fertility treatment and likely extend past the reproductive years through and beyond menopause. International surveys suggest that most patients are dissatisfied with long-term counseling related to medical and psychologic issues. We performed a review of comorbidities, including diabetes mellitus, dyslipidemia, obesity, hypertension, metabolic syndrome, depression, anxiety, obstructive sleep apnea, nonalcoholic fatty liver disease, endometrial cancer, and cardiovascular disease, in both reproductive-age and older women with PCOS. Most meta-analyses in reproductive-age women demonstrate increased risks independent from obesity. Longitudinal and cross-sectional studies including women with PCOS >40 years of age are limited in number and design, but many demonstrate that some of these comorbidities persist. All providers involved in the multidimensional care of women with PCOS should be aware of these long-term health risks to provide appropriate counseling, screening, and management options. We identify limitations that should be the focus of future studies designed to study health outcomes in postmenopausal women with PCOS. ((C) 2018 by American Society for Reproductive Medicine.)
C1 [Cooney, Laura G.] Univ Wisconsin, Dept Obstet & Gynecol, Madison, WI 53706 USA.
   [Dokras, Anuja] Univ Penn, Dept Obstet & Gynecol, Philadelphia, PA 19104 USA.
C3 University of Wisconsin System; University of Wisconsin Madison;
   University of Pennsylvania
RP Dokras, A (corresponding author), 3701 Market St,Suite 800, Philadelphia, PA 19104 USA.
EM Adokras@obgyn.upenn.edu
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NR 92
TC 161
Z9 173
U1 0
U2 37
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0015-0282
EI 1556-5653
J9 FERTIL STERIL
JI Fertil. Steril.
PD OCT
PY 2018
VL 110
IS 5
BP 794
EP 809
DI 10.1016/j.fertnstert.2018.08.021
PG 16
WC Obstetrics & Gynecology; Reproductive Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology; Reproductive Biology
GA GW4LL
UT WOS:000446885700005
PM 30316414
OA Bronze
DA 2025-06-11
ER

PT J
AU Tattersall, MC
   Jarjour, NN
   Busse, PJ
AF Tattersall, Matthew C.
   Jarjour, Nizar N.
   Busse, Paula J.
TI Systemic Inflammation in Asthma: What Are the Risks and Impacts Outside
   the Airway?
SO JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
LA English
DT Review
ID C-REACTIVE PROTEIN; ADULT-ONSET ASTHMA; QUALITY-OF-LIFE; EOSINOPHIL
   CATIONIC PROTEIN; INTIMA MEDIA THICKNESS; CORONARY-HEART-DISEASE;
   NECROSIS-FACTOR-ALPHA; CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME;
   MENTAL-DISORDERS
AB Airway in fl ammation in asthma has been well recognized for several decades, with general agreement on its role in asthma pathogenesis, symptoms, propensity toward exacerbation, and decline in lung function. This has led to universal recommendation in asthma management guidelines to incorporate the use of inhaled corticosteroid as an antiin fl ammatory therapy for all patients with persistent asthma symptoms. However, there has been limited attention paid to the presence and potential impact of systemic in fl ammation in asthma. Accumulating evidence from epidemiological observations and cohort studies points to a host of downstream organ dysfunction in asthma especially among patients with longstanding or more severe disease, frequent exacerbations, and underlying risk factors for organ dysfunction. Most studies to date have focused on cognitive impairment, depression/anxiety, metabolic syndrome, and cardiovascular abnormalities. In this review, we summarize some of the evidence demonstrating these abnormalities and highlight the proposed mechanisms and potential bene fi ts of treatment in limiting these extrapulmonary abnormalities in patients with asthma. The goal of this commentary is to raise awareness of the importance of recognizing potential extrapulmonary conditions associated with systemic in fl ammation of asthma. This area of treatment of patients with asthma is a large unmet need. (c) 2024 Published by Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology (J Allergy Clin Immunol Pract 2024;12:849-62)
C1 [Tattersall, Matthew C.; Jarjour, Nizar N.] Univ Wisconsin, Sch Med & Publ, Dept Med, Madison, WI 53792 USA.
   [Busse, Paula J.] Mt Sinai Sch Med, Icahn Sch Med, Dept Med, Div Clin Immunol, New York, NY USA.
   [Tattersall, Matthew C.] Univ Wisconsin, Sch Med & Publ Hlth, 600 Highland Ave, H4-5, Madison, WI 53792 USA.
C3 University of Wisconsin System; University of Wisconsin Madison; Icahn
   School of Medicine at Mount Sinai; University of Wisconsin System;
   University of Wisconsin Madison
RP Tattersall, MC (corresponding author), Univ Wisconsin, Sch Med & Publ Hlth, 600 Highland Ave, H4-5, Madison, WI 53792 USA.
EM mtattersall@medicine.wisc.edu
RI Fahy, John/ABS-1213-2022
FU UW Institute for Clinical and Translational Research through National
   Institutes of Health, National Center for Advancing Translational
   Sciences [KL2TR002374, UL1TR002373]; NIA [RO1 AG082215];  [R01 HL142749]
FX M. C.Tattersall was supported in part by grants KL2TR002374 and
   UL1TR002373 awarded to UW Institute for Clinical and Translational
   Research through National Institutes of Health, National Center for
   Advancing Translational Sciences. N. N. Jarjour was supported in part by
   NIA RO1 AG082215 (MPI: Drs Melissa Rosenkranz and N. N. Jarjour) . P. J.
   Busse was supported in part by R01 HL142749 (MPI: Drs Paula Busse, Juan
   Wisnivesky, and Jonathan Feldman) .
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NR 198
TC 15
Z9 15
U1 1
U2 4
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2213-2198
EI 2213-2201
J9 J ALLER CL IMM-PRACT
JI J. Allergy Clin. Immunol.-Pract.
PD APR
PY 2024
VL 12
IS 4
BP 849
EP 862
DI 10.1016/j.jaip.2024.02.004
EA APR 2024
PG 14
WC Allergy; Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Allergy; Immunology
GA RA3R4
UT WOS:001224918100001
PM 38355013
DA 2025-06-11
ER

PT J
AU Snoubar, M
   Kasim, S
   Badawi, M
   Shaban, Q
   AbuAlrub, I
   Hunjul, M
   Khelfeh, N
   Abuhassan, A
   Hanani, A
   Bilbeisi, S
   Damiri, B
AF Snoubar, Motaz
   Kasim, Salih
   Badawi, Mahdi
   Shaban, Qusay
   AbuAlrub, Ibraheem
   Hunjul, Marah
   Khelfeh, Nashat
   Abuhassan, Ahmad
   Hanani, Ahmad
   Bilbeisi, Saed
   Damiri, Basma
TI High-risk drug use among Palestinian adolescent refugees in the North
   West Bank Palestine
SO JOURNAL OF ETHNICITY IN SUBSTANCE ABUSE
LA English
DT Article
DE Drug abuse; depression; Palestinian refugee adolescents; UNRWA;
   amphetamine; THC; Palestine
ID METABOLIC SYNDROME; STREET CHILDREN; SUBSTANCE USE; HEALTH; DEPRESSION;
   SMOKING; ANXIETY; TOBACCO; YOUTH; EPIDEMIOLOGY
AB Palestinian adolescent refugees are at increased risk for behaviors that can lead to poor health outcomes, such as high-risk substance use. This research focuses on the prevalence of substance use and its relationship with depression among adolescent male refugees in Palestine's North-West Bank. A cross-sectional study was conducted in five of seven refugee camps to gather data using a proportional stratified sampling technique. A structured questionnaire-based interview was conducted to gather sociodemographic data, self-reported substance use, and depression scale information. Additionally, urine screening tests were used to detect the presence of different drugs in participants' urine samples. The final sample size was 386 refugee males; 24.0% were workers, and 13.7% worked previously. For self-reported substance use, 26.9%;12.4%; 28.0%; 37.0%; and 60.4%, 2.6% of adolescents reported current users of cigarettes, e-cigarettes, waterpipe, coffee, energy drinks (ED), and alcohol, respectively. Moreover, 3.4% tested positive for at least one drug. The drugs that tested positive were as follows: PCP (5%), MDMA (1.8%), THC (1.6%), BZO (0.5%), and MET (0.5%). The adjusted logistic regression showed an increased risk of depression among workers (OR = 3.777; p-value = 0.008), cigarette smokers (OR = 2.948; p-value = 0.04), waterpipe smokers (OR = 4.458; p-value = 0.041), and coffee users (OR = 2.883, p-value = 0.046). In conclusion, Palestinian adolescent refugees are at increased risk for behaviors that can lead to poor health outcomes, such as high-risk substance use, including illicit drugs, alcohol use, tobacco smoking, and ED intake. The results of this study reveal alarming figures on drug use associated with depression in refugee camps which demand controlling interventions.
C1 [Snoubar, Motaz; Kasim, Salih; Badawi, Mahdi; Shaban, Qusay; AbuAlrub, Ibraheem; Hunjul, Marah; Khelfeh, Nashat; Abuhassan, Ahmad; Hanani, Ahmad; Damiri, Basma] An Najah Natl Univ, Nablus, Palestine.
   [Bilbeisi, Saed] Opioid Substitut Therapy Unit, Ramallah, Palestine.
   [Damiri, Basma] An Najah Natl Univ, Fac Med & Hlth Sci, Drug & Toxicol Div, POB 7, Nablus, Palestine.
C3 An Najah National University; An Najah National University
RP Damiri, B (corresponding author), An Najah Natl Univ, Fac Med & Hlth Sci, Drug & Toxicol Div, POB 7, Nablus, Palestine.
EM bdamiri@najah.edu
RI Damiri, Basma/AAA-3348-2019; Hanani, Ahmad/ACZ-8368-2022
OI Hunjul, Marah/0000-0003-4653-1598; Damiri, Basma/0000-0001-8242-391X
FU We would like to thank Committee Services for Refugee Camps for their
   help.
FX We would like to thank Committee Services for Refugee Camps for their
   help.
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NR 60
TC 2
Z9 2
U1 2
U2 6
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 1533-2640
EI 1533-2659
J9 J ETHN SUBST ABUSE
JI J. Ethn. Subst. Abuse
PD JAN 2
PY 2025
VL 24
IS 1
BP 3
EP 22
DI 10.1080/15332640.2023.2255850
EA SEP 2023
PG 20
WC Substance Abuse
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Substance Abuse
GA W0Y2Y
UT WOS:001076350900001
PM 37698173
DA 2025-06-11
ER

PT J
AU Tovar-Palacio, C
   Torres, N
   Diaz-Villaseñor, A
   Tovar, AR
AF Tovar-Palacio, Claudia
   Torres, Nimbe
   Diaz-Villasenor, Andrea
   Tovar, Armando R.
TI The role of nuclear receptors in the kidney in obesity and metabolic
   syndrome
SO GENES AND NUTRITION
LA English
DT Review
DE Kidney; Nuclear receptors; Obesity; Metabolic syndrome
ID PREGNANE-X-RECEPTOR; CONSTITUTIVE ANDROSTANE RECEPTOR;
   UNION-OF-PHARMACOLOGY; PROLIFERATOR-ACTIVATED RECEPTORS; MESSENGER-RNA
   EXPRESSION; RENAL LIPID-METABOLISM; BODY-MASS INDEX; PPAR-ALPHA;
   CHOLESTEROL EFFLUX; MESANGIAL CELLS
AB Nuclear receptors are ligand-activated transcriptional regulators of several key aspects of renal physiology and pathophysiology. As such, nuclear receptors control a large variety of metabolic processes, including kidney lipid metabolism, drug clearance, inflammation, fibrosis, cell differentiation, and oxidative stress. Derangement of nuclear receptor regulation, that is, mainly due to obesity may induce metabolic syndrome, may contribute to the pathogenesis and progression of chronic renal disease and may result in end-stage renal disease. This places nuclear receptors at the forefront of novel therapeutic approaches for a broad range of kidney disorders and diseases, including glomerulosclerosis, tubulointerstitial disease, renal lipotoxicity, kidney fibrosis, and hypertension. This review focuses on the importance of the transcription factors peroxisome proliferator-activated receptor alpha, peroxisome proliferator-activated receptor beta, peroxisome proliferator-activated receptor gamma, liver X receptors, farnesoid X receptor, and the pregnane X receptor/steroid and xenobiotic receptor (PXR) on the physiology and pathophysiology of renal diseases associated with obesity and metabolic syndrome.
C1 [Tovar-Palacio, Claudia] Natl Med Sci & Nutr Inst, Dept Nephrol & Mineral Metab, Mexico City 14000, DF, Mexico.
   [Torres, Nimbe; Diaz-Villasenor, Andrea; Tovar, Armando R.] Natl Med Sci & Nutr Inst, Dept Nutr Physiol, Mexico City 14000, DF, Mexico.
RP Tovar-Palacio, C (corresponding author), Natl Med Sci & Nutr Inst, Dept Nephrol & Mineral Metab, Vasco de Quiroga 15, Mexico City 14000, DF, Mexico.
EM tovarpal@gmail.com
RI Torres, Nimbe/AAI-4340-2020; Tovar-Palacio, Claudia/AAE-4572-2022
OI Diaz-Villasenor, Andrea/0000-0003-1222-2615; Tovar-Palacio,
   Claudia/0000-0001-7965-6421
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NR 127
TC 24
Z9 27
U1 0
U2 17
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1555-8932
EI 1865-3499
J9 GENES NUTR
JI Genes Nutr.
PD OCT
PY 2012
VL 7
IS 4
BP 483
EP 498
DI 10.1007/s12263-012-0295-5
PG 16
WC Genetics & Heredity; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Genetics & Heredity; Nutrition & Dietetics
GA 010EY
UT WOS:000309078700003
PM 22532116
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Johnson, RJ
   Perez-Pozo, SE
   Sautin, YY
   Manitius, J
   Sanchez-Lozada, LG
   Feig, DI
   Shafiu, M
   Segal, M
   Glassock, RJ
   Shimada, M
   Roncal, C
   Nakagawa, T
AF Johnson, Richard J.
   Perez-Pozo, Santos E.
   Sautin, Yuri Y.
   Manitius, Jacek
   Sanchez-Lozada, Laura Gabriela
   Feig, Daniel I.
   Shafiu, Mohamed
   Segal, Mark
   Glassock, Richard J.
   Shimada, Michiko
   Roncal, Carlos
   Nakagawa, Takahiko
TI Hypothesis: Could Excessive Fructose Intake and Uric Acid Cause Type 2
   Diabetes?
SO ENDOCRINE REVIEWS
LA English
DT Review
ID IMPAIRED GLUCOSE-TOLERANCE; MUSCLE-CELL-PROLIFERATION; SOFT DRINK
   CONSUMPTION; 3RD NATIONAL-HEALTH; SERUM URATE LEVELS; INCREASED
   OXIDATIVE STRESS; VITAMIN-C SUPPLEMENTATION; SUGAR-SWEETENED BEVERAGES;
   CORONARY-HEART-DISEASE; FATTY LIVER-DISEASE
AB We propose that excessive fructose intake (>50 g/d) may be one of the underlying etiologies of metabolic syndrome and type 2 diabetes. The primary sources of fructose are sugar (sucrose) and high fructose corn syrup. First, fructose intake correlates closely with the rate of diabetes worldwide. Second, unlike other sugars, the ingestion of excessive fructose induces features of metabolic syndrome in both laboratory animals and humans. Third, fructose appears to mediate the metabolic syndrome in part by raising uric acid, and there are now extensive experimental and clinical data supporting uric acid in the pathogenesis of metabolic syndrome. Fourth, environmental and genetic considerations provide a potential explanation of why certain groups might be more susceptible to developing diabetes. Finally, we discuss the counterarguments associated with the hypothesis and a potential explanation for these findings. If diabetes might result from excessive intake of fructose, then simple public health measures could have a major impact on improving the overall health of our populace. (Endocrine Reviews 30: 96-116, 2009)
C1 [Johnson, Richard J.; Sautin, Yuri Y.; Sanchez-Lozada, Laura Gabriela; Shafiu, Mohamed; Segal, Mark; Glassock, Richard J.; Shimada, Michiko; Roncal, Carlos; Nakagawa, Takahiko] Univ Florida, Div Nephrol, Gainesville, FL 32620 USA.
   [Perez-Pozo, Santos E.] Mateo Orfila Hosp, Div Nephrol, Minorca 07703, Balearic Isl, Spain.
   [Manitius, Jacek] Ludwig Rydygier Med Univ, Div Nephrol, PL-85067 Bydgoszcz, Poland.
   [Sanchez-Lozada, Laura Gabriela] Inst Nacl Cardiol Ignacio Chavez, Dept Nephrol, Mexico City 14080, DF, Mexico.
   [Feig, Daniel I.] Baylor Coll Med, Div Pediat Nephrol, Houston, TX 77030 USA.
C3 State University System of Florida; University of Florida; Hospital
   Mateu Orfila; Nicolaus Copernicus University; National Institute of
   Cardiology - Mexico; Baylor College of Medicine
RP Johnson, RJ (corresponding author), Univ Florida, Div Nephrol Hypertens & Transplantat, POB 100224, Gainesville, FL 32620 USA.
EM johnsrj@medicine.ufl.edu
RI Sanchez-Lozada, Laura/AAS-2104-2021
OI Sanchez-Lozada, Laura-Gabriela/0000-0003-0348-9617; Segal,
   Mark/0000-0002-5502-2042; Sautin, Yuri/0000-0003-3618-5134; Feig,
   Daniel/0000-0002-0017-6335
FU U. S. Public Health Service [DK-52121, HL-68607]; American Heart
   Association [0755595B]; CONACyT, Mexico [081054]; American Heart
   Association (AHA) [0755595B] Funding Source: American Heart Association
   (AHA)
FX Support for this publication was provided by U. S. Public Health Service
   Grants DK-52121 and HL-68607, by American Heart Association Grant
   0755595B ( to Y. Y. S.), and by generous monies from Gatorade. L. G.
   S.-L. is supported by Grant 081054 from CONACyT, Mexico.
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NR 316
TC 375
Z9 420
U1 1
U2 56
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0163-769X
EI 1945-7189
J9 ENDOCR REV
JI Endocr. Rev.
PD FEB
PY 2009
VL 30
IS 1
BP 96
EP 116
DI 10.1210/er.2008-0033
PG 21
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 403ZO
UT WOS:000263120700004
PM 19151107
OA Bronze, Green Accepted, Green Published
DA 2025-06-11
ER

PT J
AU Ambroselli, D
   Masciulli, F
   Romano, E
   Catanzaro, G
   Besharat, ZM
   Massari, MC
   Ferretti, E
   Migliaccio, S
   Izzo, L
   Ritieni, A
   Grosso, M
   Formichi, C
   Dotta, F
   Frigerio, F
   Barbiera, E
   Giusti, AM
   Ingallina, C
   Mannina, L
AF Ambroselli, Donatella
   Masciulli, Fabrizio
   Romano, Enrico
   Catanzaro, Giuseppina
   Besharat, Zein Mersini
   Massari, Maria Chiara
   Ferretti, Elisabetta
   Migliaccio, Silvia
   Izzo, Luana
   Ritieni, Alberto
   Grosso, Michela
   Formichi, Caterina
   Dotta, Francesco
   Frigerio, Francesco
   Barbiera, Eleonora
   Giusti, Anna Maria
   Ingallina, Cinzia
   Mannina, Luisa
TI New Advances in Metabolic Syndrome, from Prevention to Treatment: The
   Role of Diet and Food
SO NUTRIENTS
LA English
DT Review
DE metabolic syndrome; food; food components; diet; metabolomics;
   biomarkers
ID POLYUNSATURATED FATTY-ACID; REFINED-GRAIN CONSUMPTION;
   INSULIN-RESISTANCE; CARDIOVASCULAR-DISEASE; WEIGHT-LOSS; CHLOROGENIC
   ACID; FISH CONSUMPTION; OXIDATIVE STRESS; BLOOD-PRESSURE; RISK-FACTORS
AB The definition of metabolic syndrome (MetS) has undergone several changes over the years due to the difficulty in establishing universal criteria for it. Underlying the disorders related to MetS is almost invariably a pro-inflammatory state related to altered glucose metabolism, which could lead to elevated cardiovascular risk. Indeed, the complications closely related to MetS are cardiovascular diseases (CVDs) and type 2 diabetes (T2D). It has been observed that the predisposition to metabolic syndrome is modulated by complex interactions between human microbiota, genetic factors, and diet. This review provides a summary of the last decade of literature related to three principal aspects of MetS: (i) the syndrome's definition and classification, pathophysiology, and treatment approaches; (ii) prediction and diagnosis underlying the biomarkers identified by means of advanced methodologies (NMR, LC/GC-MS, and LC, LC-MS); and (iii) the role of foods and food components in prevention and/or treatment of MetS, demonstrating a possible role of specific foods intake in the development of MetS.
C1 [Ambroselli, Donatella; Masciulli, Fabrizio; Romano, Enrico; Ingallina, Cinzia; Mannina, Luisa] Sapienza Univ Rome, Dept Chem & Technol Drugs, Lab Food Chem, I-00185 Rome, Italy.
   [Catanzaro, Giuseppina; Besharat, Zein Mersini; Massari, Maria Chiara; Ferretti, Elisabetta; Frigerio, Francesco; Barbiera, Eleonora; Giusti, Anna Maria] Sapienza Univ Rome, Dept Expt Med, I-00161 Rome, Italy.
   [Migliaccio, Silvia] Univ Foro Italico, Dept Movement Human & Hlth Sci, Hlth Sci Sect, I-00135 Rome, Italy.
   [Izzo, Luana; Ritieni, Alberto] Univ Naples Federico II, Dept Pharm, I-80131 Naples, Italy.
   [Ritieni, Alberto] Univ Naples Federico II, UNESCO, Hlth Educ & Sustainable Dev, I-80131 Naples, Italy.
   [Grosso, Michela] Univ Naples Federico II, Dept Mol Med & Med Biotechnol, I-80131 Naples, Italy.
   [Formichi, Caterina; Dotta, Francesco] Univ Siena, Dept Med, Diabet Unit, Surg & Neurosci, I-53100 Siena, Italy.
C3 Sapienza University Rome; Sapienza University Rome; Foro Italico
   University of Rome; University of Naples Federico II; University of
   Naples Federico II; University of Naples Federico II; University of
   Siena
RP Ingallina, C (corresponding author), Sapienza Univ Rome, Dept Chem & Technol Drugs, Lab Food Chem, I-00185 Rome, Italy.; Giusti, AM (corresponding author), Sapienza Univ Rome, Dept Expt Med, I-00161 Rome, Italy.
EM annamaria.giusti@uniroma1.it; cinzia.ingallina@uniroma1.it
RI catanzaro, giuseppina/AGZ-8080-2022; Mannina, Luisa/AGY-1694-2022;
   Romano, Enrico/LOS-6881-2024; Formichi, Caterina/HGA-5525-2022; Ritieni,
   Alberto/G-8490-2012; Dotta, Francesco/AAF-1123-2019; Ingallina,
   Cinzia/AGX-9596-2022; Besharat, Zein Mersini/A-3898-2015; Ferretti,
   Elisabetta/G-5413-2013; catanzaro, giuseppina/J-8158-2018
OI MASCIULLI, FABRIZIO/0000-0002-4518-534X; Grosso,
   Michela/0000-0003-1664-1657; Izzo, Luana/0000-0002-8365-9032; Ingallina,
   Cinzia/0000-0003-4817-7318; Migliaccio, Silvia/0000-0002-4563-6630;
   Ritieni, Alberto/0000-0003-0314-8839; Frigerio,
   Francesco/0000-0002-9502-3314; Ambroselli,
   Donatella/0000-0002-7499-3944; Besharat, Zein
   Mersini/0000-0003-0317-9854; Ferretti, Elisabetta/0000-0001-7265-6429;
   Mannina, Luisa/0000-0001-8659-5890; Giusti, Anna
   Maria/0000-0002-5694-3732; catanzaro, giuseppina/0000-0001-8427-9691
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NR 227
TC 84
Z9 85
U1 26
U2 113
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD FEB
PY 2023
VL 15
IS 3
AR 640
DI 10.3390/nu15030640
PG 38
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 8V7NQ
UT WOS:000930816000001
PM 36771347
OA Green Published, gold
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Ryu, H
   Kim, Y
   Lee, J
   Yoon, SJ
   Cho, JH
   Wong, E
   Jung, J
AF Ryu, Hosihn
   Kim, Youngnam
   Lee, Juneyoung
   Yoon, Seok-jun
   Cho, Jeong-hyun
   Wong, Erica
   Jung, Jiyeon
TI Office Workers' Risk of Metabolic Syndrome-Related Indicators: A 10-Year
   Cohort Study
SO WESTERN JOURNAL OF NURSING RESEARCH
LA English
DT Article
DE metabolic syndrome; work tenure; office worker; cohort study; Korea
ID PHYSICAL-ACTIVITY; CARDIORESPIRATORY FITNESS; INTERVENTION PROGRAM;
   LEISURE-TIME; JOB STRAIN; PREVALENCE; STRESS; HEALTH; BEHAVIORS; MEN
AB The purpose of the study is to assess the relationship between the prevalence of metabolic syndrome-related risk factors and work tenure among office workers. A 10-year cohort analysis was conducted using employees' health examinations given to new employees within 1 or 2 years of joining the firm and every 5 years thereafter. Age-adjusted odds ratios (95% confidence interval [CI], p < .05) were calculated based on a contrast test with general estimating equations. Specifically, the age-adjusted odds ratios and CIs of those with 20 +/- 1 years of work, compared with those with 1 to 2 years of work, were as follows: triglycerides (150 mg/dl) 3.01 (2.11, 4.28), waist circumference (male 90 cm) 2.70 (1.63, 4.45), and fasting glucose (100 mg/dl) 2.67 (1.78, 4.01). The findings of the relationship between metabolic syndrome risk and work tenure as well as the baseline health data of new employees provide a foundation for developing a workplace health management system.
C1 [Ryu, Hosihn; Lee, Juneyoung; Yoon, Seok-jun; Jung, Jiyeon] Korea Univ, Seoul, South Korea.
   [Kim, Youngnam] Daewoo Int Corp, Seoul, South Korea.
   [Cho, Jeong-hyun] Inje Univ, Busan, South Korea.
   [Wong, Erica] Univ Michigan, Ann Arbor, MI 48109 USA.
C3 Korea University; Inje University; University of Michigan System;
   University of Michigan
RP Jung, J (corresponding author), Korea Univ, Coll Nursing, 145 Anam Ro, Seoul 02841, South Korea.
EM hepburn86@korea.ac.kr
RI Cho, Jeonghyun/MEO-0743-2025; Jung, Jiyeon/AAD-7727-2021
OI Cho, Jeonghyun/0000-0003-4492-1197; Yoon, Seok-Jun/0000-0003-3297-0071;
   Jung, Jiyeon/0000-0002-8295-3424; Lee, Juneyoung/0000-0001-8073-9304
FU Basic Science Research Program through the National Research Foundation
   of Korea (NRF) - Ministry of Education, Science and Technology
   [2012R1A1A2042155]
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: This
   research was supported by Basic Science Research Program through the
   National Research Foundation of Korea (NRF) funded by the Ministry of
   Education, Science and Technology (2012R1A1A2042155).
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NR 34
TC 9
Z9 9
U1 0
U2 15
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0193-9459
EI 1552-8456
J9 WESTERN J NURS RES
JI West. J. Nurs. Res.
PD NOV
PY 2016
VL 38
IS 11
BP 1433
EP 1447
DI 10.1177/0193945916654134
PG 15
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA DZ6GS
UT WOS:000385960300003
PM 27330047
DA 2025-06-11
ER

PT J
AU Das, UN
AF Das, Undurti Narasimha
TI Lipoxins, resolvins, protectins, maresins and nitrolipids, and their
   clinical implications with specific reference to cancer: part I
SO CLINICAL LIPIDOLOGY
LA English
DT Review
DE antioxidant; cytokine; inflammation; lipoxin; nitric oxide; nitrolipid;
   polyunsaturated fatty acid; protectin; reactive oxygen species; resolvin
ID ESSENTIAL FATTY-ACIDS; TUMOR-NECROSIS-FACTOR; GAMMA-LINOLENIC ACID;
   C-REACTIVE PROTEIN; FREE-RADICAL GENERATION; INDUCED GENETIC-DAMAGE;
   METABOLIC SYNDROME-X; DOCOSAHEXAENOIC ACID; ARACHIDONIC-ACID;
   NITRIC-OXIDE
AB Obesity, insulin resistance, essential hypertension, Type 2 diabetes, nonalcoholic fatty liver disease, coronary heart disease, osteoporosis, renal failure, Alzheimer's disease, depression, schizophrenia, aging, rheumatological conditions and cancer are low-grade systemic inflammatory conditions in which there is an increase in proinflammatory cytokines and reactive oxygen species, reactive nitrogen species, and proinflammatory eicosanoids, while a decrease in the cellular antioxidants, anti-inflammatory cytokines and certain polyunsaturated fatty acids, and their anti-inflammatory products such as lipoxins (LXs), resolvins (Rvs), protectins, maresins and nitrolipids occurs. This imbalance between the pro- and anti-inflammatory molecules in these diseases suggests that therapeutic strategies directed to suppress inappropriate inflammation may aid recovery from these diseases. It is proposed that both local and systemic delivery of LXs, Rvs, protectins, maresins and nitrolipids, and/or their more stable synthetic analogs, may prove to be useful in these diseases. In this part I of the review, the discussion is centered on the role of LXs, Rvs, protectins and nitrolipids in cancer.
C1 [Das, Undurti Narasimha] Jawaharlal Nehru Technol Univ, Kakinada 533003, India.
   [Das, Undurti Narasimha] Gayatri Vidya Parishad Coll Engn, Biosci Res Ctr, Visakhapatnam 530048, Andhra Pradesh, India.
C3 Jawaharlal Nehru Technological University - Kakinada; Gayatri Vidya
   Parishad College of Engineering
EM undurti@hotmail.com
RI Das, Undurti/A-7918-2009
FU Department of Biotechnology, New Delhi, India; Department of
   Biotechnology (DBT) [BT/PR11627/MED/30/157/2010]; Department of Science
   and Technology under Intensification of Research in High Priority Areas
   [IR/SO/LU/03/2008/1]; Defence Research and Development Organisation, New
   Delhi, India under RD Project [TC/2519/INM-03/2011/CARS, INM-311]
FX UN Das is in receipt of the Ramalingaswami Fellowship of the Department
   of Biotechnology, New Delhi, India, during the tenure of this study.
   This work was supported by grants from the Department of Biotechnology
   (DBT No BT/PR11627/MED/30/157/2010), the Department of Science and
   Technology (No. IR/SO/LU/03/2008/1) under Intensification of Research in
   High Priority Areas, and the Defence Research and Development
   Organisation, New Delhi, India (TC/2519/INM-03/2011/CARS under R&D
   Project INM-311) to UN Das. The author has no other relevant
   affiliations or financial involvement with any organization or entity
   with a financial interest in or financial conflict with the subject
   matter or materials discussed in the manuscript apart from those
   disclosed.
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NR 203
TC 25
Z9 26
U1 1
U2 26
PU FUTURE MEDICINE LTD
PI LONDON
PA UNITEC HOUSE, 3RD FLOOR, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON, N3
   1QB, ENGLAND
SN 1758-4299
EI 1758-4302
J9 CLIN LIPIDOL
JI Clin. Lipidol.
PD AUG
PY 2013
VL 8
IS 4
BP 437
EP 463
DI 10.2217/CLP.13.31
PG 27
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 197ZJ
UT WOS:000322891100013
DA 2025-06-11
ER

PT J
AU Bigio, B
   Mathé, AA
   Sousa, VC
   Zelli, D
   Svenningsson, P
   McEwen, BS
   Nasca, C
AF Bigio, Benedetta
   Mathe, Aleksander A.
   Sousa, Vasco C.
   Zelli, Danielle
   Svenningsson, Per
   McEwen, Bruce S.
   Nasca, Carla
TI Epigenetics and energetics in ventral hippocampus mediate rapid
   antidepressant action: Implications for treatment resistance
SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF
   AMERICA
LA English
DT Article
DE metabolic factors; acetylcarnitine; dentate gyrus; insulin; RNAseq
ID ACETYL-L-CARNITINE; INSULIN-RESISTANCE; ALZHEIMERS-DISEASE; METABOLIC
   SYNDROME; STRESS; BRAIN; DISORDERS; DEPRESSION; ADIPONECTIN;
   GLUCOCORTICOIDS
AB Although regulation of energy metabolism has been linked with multiple disorders, its role in depression and responsiveness to antidepressants is less known. We found that an epigenetic and energetic agent, acetyl-L-carnitine (LAC, oral administration), rapidly rescued the depressive- and central and systemic metabolic-like phenotype of LAC-deficient Flinders Sensitive Line rats (FSL). After acute stress during LAC treatment, a subset of FSL continued to respond to LAC (rFSL), whereas the other subset did not (nrFSL). RNA sequencing of the ventral dentate gyrus, a mood-regulatory region, identified metabolic factors as key markers predisposing to depression (insulin receptors Insr, glucose transporters Glut-4 and Glut-12, and the regulator of appetite Cartpt) and to LAC responsiveness (leptin receptors Lepr, metabotropic glutamate receptors-2 mGlu2, neuropeptide-Y NPY, and mineralocorticoid receptors MR). Furthermore, we found that stress-induced treatment resistance in nrFSL shows a new gene profile, including the metabolic regulator factors elongation of long chain fatty acids 7 (Elovl7) and cytochrome B5 reductase 2 (Cyb5r2) and the synaptic regulator NPAS4. Finally, while improving central energy regulation and exerting rapid antidepressant-like effects, LAC corrected a systemic hyperinsulinemia and hyperglicemia in rFSL and failed to do that in nrFSL. These findings establish CNS energy regulation as a factor to be considered for the development of better therapeutics. Agents such as LAC that regulate metabolic factors and reduce glutamate overflow could rapidly ameliorate depression and could also be considered for treatment of insulin resistance in depressed subjects. The approach here serves as a model for identifying markers and underlying mechanisms of predisposition to diseases and treatment responsiveness that may be useful in translation to human behavior and psychopathology.
C1 [Bigio, Benedetta] Rockefeller Univ, Ctr Clin & Translat Sci, New York, NY 10065 USA.
   [Bigio, Benedetta; Zelli, Danielle; McEwen, Bruce S.; Nasca, Carla] Rockefeller Univ, Neuroendocrinol Lab, New York, NY 10065 USA.
   [Mathe, Aleksander A.; Sousa, Vasco C.; Svenningsson, Per] Karolinska Inst, Dept Clin Neurosci, S-17177 Stockholm, Sweden.
C3 Rockefeller University; Rockefeller University; Karolinska Institutet
RP Bigio, B (corresponding author), Rockefeller Univ, Ctr Clin & Translat Sci, New York, NY 10065 USA.; Bigio, B; McEwen, BS; Nasca, C (corresponding author), Rockefeller Univ, Neuroendocrinol Lab, New York, NY 10065 USA.
EM bbigio@rockefeller.edu; mcewen@rockefeller.edu; cnasca@rockefeller.edu
RI McEwen, Bruce/Z-1630-2019; Nasca, Carla/L-8956-2017; Svenningsson,
   Per/K-5210-2014; Sousa, Vasco/GWC-1295-2022
OI Svenningsson, Per/0000-0001-6727-3802; Sousa, Vasco/0000-0002-0086-6168
FU American Foundation for Suicide Prevention; Hope for Depression Research
   Foundation; National Center for Advancing Translational Sciences [UL1
   TR000043]; NIH Clinical and Translational Science Award program;
   Wenner-Gren Foundations; Swedish Medical Research Council [10414]
FX This work was supported by American Foundation for Suicide Prevention,
   Hope for Depression Research Foundation, Grant UL1 TR000043 from the
   National Center for Advancing Translational Sciences, the NIH Clinical
   and Translational Science Award program, The Wenner-Gren Foundations,
   and Swedish Medical Research Council Grant 10414.
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NR 40
TC 73
Z9 78
U1 0
U2 18
PU NATL ACAD SCIENCES
PI WASHINGTON
PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA
SN 0027-8424
J9 P NATL ACAD SCI USA
JI Proc. Natl. Acad. Sci. U. S. A.
PD JUL 12
PY 2016
VL 113
IS 28
BP 7906
EP 7911
DI 10.1073/pnas.1603111113
PG 6
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA DR1VX
UT WOS:000379694100061
PM 27354525
OA Green Published
DA 2025-06-11
ER

PT J
AU De Long, NE
   Hyslop, JR
   Raha, S
   Hardy, DB
   Holloway, AC
AF De Long, Nicole E.
   Hyslop, Jillian R.
   Raha, Sandeep
   Hardy, Daniel B.
   Holloway, Alison C.
TI Fluoxetine-induced pancreatic beta cell dysfunction: New insight into
   the benefits of folic acid in the treatment of depression
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Beta cell; Antidepressant Selective serotonin reuptake inhibitor;
   Mitochondrial dysfunction; Reactive oxygen species; Folic acid
ID ENZYME GENE-EXPRESSION; MITOCHONDRIAL DYSFUNCTION; ANTIDEPRESSANT USE;
   METABOLIC SYNDROME; INSULIN-SECRETION; OXIDATIVE STRESS; RISK-FACTOR;
   METAANALYSIS; ASSOCIATION; ACTIVATION
AB Background: Major depressive disorder is a common psychiatric illness with reported prevalence rates of 12-16% in persons aged 12 and over. Depression is also associated with a high risk of new onset of type 2 diabetes (T2D). This relationship between depression and diabetes may be related to depression itself and/or drugs prescribed. Importantly, the use of selective serotonin reuptake inhibitors (SSRIs), the most commonly prescribed class of antidepressants, increases the risk of developing T2D. However, the mechanism(s) underlying this association remains elusive.
   Methods: Here we examine the effects of the SSRI fluoxetine (Prozac (R)) on beta cell function utilizing INS-1E cells, a rat beta cell line, to elucidate the underlying molecular mechanisms.
   Results: Fluoxetine treatment significantly reduced glucose stimulated insulin secretion (GSIS). This decreased beta cell function was concomitant with an increased production of reactive oxygen species and oxidative damage which may contribute to decreased mitochondrial electron transport chain enzyme (ETC) activity. Importantly the fluoxetine-induced deficits in beta cell function were prevented by the addition of the antioxidant folic acid.
   Limitations: These studies were conducted in vitro; the in vivo relevance remains to be determined.
   Conclusions: These findings suggest that use of SSRI antidepressants may increase the risk of new onset T2D by causing oxidative stress in pancreatic beta cells. However, folic acid supplementation in patients taking SSRIs may reduce the risk of new onset diabetes via protection of normal beta cell function. (C) 2014 Published by Elsevier B.V.
C1 [De Long, Nicole E.; Hyslop, Jillian R.; Holloway, Alison C.] McMaster Univ, Dept Obstet & Gynecol, Hamilton, ON L8S 4K1, Canada.
   [Raha, Sandeep] McMaster Univ, Dept Pediat, Hamilton, ON L8S 4K1, Canada.
   [Hardy, Daniel B.] Western Univ, Dept Obstet & Gynecol, London, ON N6A 5C1, Canada.
   [Hardy, Daniel B.] Western Univ, Dept Physiol & Pharmacol, London, ON N6A 5C1, Canada.
C3 McMaster University; McMaster University; Western University (University
   of Western Ontario); Western University (University of Western Ontario)
RP Holloway, AC (corresponding author), McMaster Univ, Dept Obstet & Gynecol, RM HSC 3N5,21280 Main St West, Hamilton, ON L8S 4K1, Canada.
EM hollow@mcmaster.ca
RI Raha, Sandeep/AAF-3655-2020; Hardy, Daniel/GYU-8976-2022
OI Raha, Sandeep/0000-0001-7307-3292; Hardy, Daniel/0000-0001-5445-273X
FU Canadian Institutes of Health Research [MOP 119323]; CIHR Training
   Program in Reproduction, Early Development and the Impact on Health
   (REDIH)
FX Funding for this study was provided by the Canadian Institutes of Health
   Research (MOP 119323). Salary support for NED was provided by the CIHR
   Training Program in Reproduction, Early Development and the Impact on
   Health (REDIH).
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NR 75
TC 25
Z9 25
U1 0
U2 32
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD SEP
PY 2014
VL 166
BP 6
EP 13
DI 10.1016/j.jad.2014.04.063
PG 8
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA AK8UV
UT WOS:000338705000002
PM 25012404
DA 2025-06-11
ER

PT J
AU Sukhija, R
   Kakar, P
   Mehta, V
   Mehta, JL
AF Sukhija, Rishi
   Kakar, Priyanka
   Mehta, Vimal
   Mehta, Jawahar L.
TI Enhanced 11β-hydroxysteroid dehydrogenase activity, the metabolic
   syndrome, and systemic hypertension
SO AMERICAN JOURNAL OF CARDIOLOGY
LA English
DT Review
ID HUMAN ADIPOSE-TISSUE; HUMAN OBESITY; CORTISOL METABOLISM; TYPE-1
   ACTIVITY; MESSENGER-RNA; IN-VIVO; INSULIN-RESISTANCE; LIPASE ACTIVITY;
   WEIGHT-LOSS; EXPRESSION
AB Metabolic syndrome, with its attendant cardiovascular complications, is reaching epidemic proportions worldwide; hence, there is intense interest in understanding the pathogenesis of and developing therapy for these common disorders. Recent studies have suggested that metabolic syndrome may be a stress response, with an underlying abnormality in the enzyme llorhydroxysteroid dehydrogenase. At the cellular level, the enzyme 4ydroxysteroid dehydrogenase type 1 (HSD1) locally regenerates active cortisol from inactive cortisone, amplifying glucocorticoid receptor activation and promoting preadipocyte differentiation and adipocyte hypertrophy. Although initial studies in transgenic mice and humans are encouraging, more data are required to conclusively prove the hypothesis that the adipose-tissue-specific overexpression of HSD1 and the resultant increase in tissue-specific cortisol concentrations result in human obesity, insulin resistance, high blood pressure, and metabolic syndrome. Currently, selective inhibitors of HSD1 are not available for human use; however, their development is under way. The use of potent and selective HSDI inhibitors will finally confirm or refute this hypothesis and may turn out to be an effective strategy for combating these common maladies. (c) 2006 Elsevier Inc. All rights reserved.
C1 Univ Arkansas Med Sci, Div Cardiovasc Med, Little Rock, AR 72205 USA.
   Cent Arkansas Vet Healthcare Syst, Little Rock, AR USA.
C3 University of Arkansas System; University of Arkansas Medical Sciences;
   US Department of Veterans Affairs; Veterans Health Administration (VHA);
   Central Arkansas Veterans Healthcare System
RP Mehta, JL (corresponding author), Univ Arkansas Med Sci, Div Cardiovasc Med, Little Rock, AR 72205 USA.
EM mehtaj@uams.edu
RI Mehta, jl/AAB-8832-2019
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NR 39
TC 23
Z9 24
U1 0
U2 0
PU EXCERPTA MEDICA INC
PI BRIDGEWATER
PA 685 ROUTE 202-206, BRIDGEWATER, NJ 08807 USA
SN 0002-9149
J9 AM J CARDIOL
JI Am. J. Cardiol.
PD AUG 15
PY 2006
VL 98
IS 4
BP 544
EP 548
DI 10.1016/j.amjcard.2006.03.028
PG 5
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 077OO
UT WOS:000240039500024
PM 16893715
DA 2025-06-11
ER

PT J
AU Priyadarshini, M
   Kamal, MA
   Greig, NH
   Reale, M
   Abuzenadah, AM
   Chaudhary, AGA
   Damanhouri, GA
AF Priyadarshini, Medha
   Kamal, Mohammad A.
   Greig, Nigel H.
   Reale, Marcella
   Abuzenadah, Adel M.
   Chaudhary, Adeel G. A.
   Damanhouri, Ghazi A.
TI Alzheimer's Disease And Type 2 Diabetes: Exploring The Association To
   Obesity And Tyrosine Hydroxylase
SO CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
LA English
DT Article
DE Type 2 diabetes mellitus; Alzheimer's disease; Parkinson's disease;
   neurodegeneration; tyrosine hydroxylase; dementia; obesity; insulin
   resistance; metabolic syndrome; neuroinflammation
ID GROWTH-FACTOR EXPRESSION; BETA-CELL FUNCTION; INSULIN-RESISTANCE;
   PARKINSONS-DISEASE; CHOLINERGIC TRANSMISSION; CARDIOVASCULAR-DISEASE;
   IMPAIRED INSULIN; NERVOUS-SYSTEM; BLOOD-PRESSURE; LEWY BODIES
AB Alzheimer's disease (AD) and type 2 diabetes mellitus (T2DM) are two debilitating health disorders afflicting millions worldwide. Recent research has revealed similarities between AD and T2DM. Both these protein conformational disorders are associated with obesity, insulin resistance, inflammation and endoplasmic reticulum stress, en-route initiation and/or stage aggravation. In this mini review we have tried to summarize studies describing obesity, insulin resistance and glucocorticoid imbalance as common patho-mechanisms in T2DM and AD. A reduction in tyrosine hydroxylase (TH) in the brain has been found to occur in Parkinson's disease (PD). AD, T2DM and PD share common risk factors like depression. Thus, whether TH is involved in the 'state of cognitive depression' that is the hallmark of AD and often accompanies PD and T2DM is also explored.
C1 [Priyadarshini, Medha] Aligarh Muslim Univ, Fac Life Sci, Dept Biochem, Aligarh 202002, Uttar Pradesh, India.
   [Kamal, Mohammad A.; Abuzenadah, Adel M.; Chaudhary, Adeel G. A.; Damanhouri, Ghazi A.] King Abdulaziz Univ, King Fahd Med Res Ctr, Jeddah 21589, Saudi Arabia.
   [Greig, Nigel H.] NIA, Drug Design & Dev Sect, Neurosci Lab, Intramural Res Program,NIH, Baltimore, MD 21224 USA.
   [Reale, Marcella] Univ G dAnnunzio, Dept Biomed Sci, Chieti, Italy.
C3 Aligarh Muslim University; King Abdulaziz University; National
   Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA);
   G d'Annunzio University of Chieti-Pescara
RP Priyadarshini, M (corresponding author), Aligarh Muslim Univ, Fac Life Sci, Dept Biochem, Aligarh 202002, Uttar Pradesh, India.
EM medha.priyadarshini@gmail.com
RI Priyadarshini, Medha/AAQ-7630-2020; Reale, Marcella/G-4299-2013;
   Damanhouri, Ghazi/Q-7901-2019; Kamal, Mohammad Amjad/J-2918-2014
OI Kamal, Mohammad Amjad/0000-0003-0088-0565; Reale,
   Marcella/0000-0002-4164-8781; Priyadarshini, Medha/0000-0003-2972-2528
FU National Institute on Aging; NIH; Italian MIUR
FX The facilities provided to MP by the Department of Science and
   Technology (New Delhi), Aligarh Muslim University (Aligarh), India; and
   to MAK by the KFMRC, King Abdulaziz University, Jeddah, Saudi Arabia are
   gratefully acknowledged. NG is supported by the Intramural Research
   Program of the National Institute on Aging, NIH, and MR gratefully
   acknowledges support by grants from the Italian MIUR.
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NR 110
TC 43
Z9 48
U1 0
U2 22
PU BENTHAM SCIENCE PUBL
PI BUSUM
PA PO BOX 294, BUSUM, 1400 AG, NETHERLANDS
SN 1871-5273
EI 1996-3181
J9 CNS NEUROL DISORD-DR
JI CNS Neurol. Disord.-Drug Targets
PD JUN
PY 2012
VL 11
IS 4
BP 482
EP 489
DI 10.2174/187152712800792767
PG 8
WC Neurosciences; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pharmacology & Pharmacy
GA 952UQ
UT WOS:000304818900018
PM 22583431
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Fu, Y
   Yuan, PP
   Zeng, MN
   Zhang, Q
   Hou, Y
   Gao, LY
   Wei, YX
   Zheng, YJ
   Feng, WS
   Zheng, XK
AF Fu, Yang
   Yuan, PeiPei
   Zeng, Mengnan
   Zhang, Qi
   Hou, Ying
   Gao, Liyuan
   Wei, Yaxin
   Zheng, Yajuan
   Feng, Weisheng
   Zheng, Xiaoke
TI Dihydroquercetin regulates HIF-1 α /AKT/NR2B signalling to improve
   impaired brain function in rats with metabolic syndrome
SO HELIYON
LA English
DT Article
DE Dihydroquercetin; Hypertension; Brain; Metabolic syndrome; HIF-1
   alpha/AKT/NR2B
ID ACTIVATION; INDUCTION; PATHWAY; DAMAGE
AB Dihydroquercetin (DHQ) is commonly used as a dietary additive, but its activity in improving brain injury with metabolic syndrome (MS) remains known. In present study, the MS rat model was induced using 10 % fructose water. The apoptosis rate of primary brain cells was detected. The HIF-1 alpha/AKT/NR2B signalling pathway, levels of KEAP1/NRF2, HO -1 and NQO-1 were detected. In vitro experiments were performed using H 2 O 2 -stimulated PC -12 cells. The effect of DHQ on rates of cell survival and apoptosis were detected. After silencing HIF-1 alpha, we further elucidate the mechanism of action of DHQ. The results indicated that DHQ reduced the hyperactivity and inhibited oxidative stress via increasing the levels of HIF-1 alpha/AKT/NR2B signalling pathway, whereas regulated KEAP1/NRF2 pathway. In vitro experiments showed that the HIF-1 alpha plays an important role in this process. Overall, DHQ may improve impaired brain function in rats with metabolic syndrome by regulating the HIF-1 alpha/AKT/NR2B signalling pathway.
C1 [Fu, Yang; Yuan, PeiPei; Zeng, Mengnan; Zhang, Qi; Hou, Ying; Gao, Liyuan; Wei, Yaxin; Zheng, Yajuan; Feng, Weisheng; Zheng, Xiaoke] Henan Univ Chinese Med, Dept Pharm, Zhengzhou 450046, Peoples R China.
   [Fu, Yang; Yuan, PeiPei; Zeng, Mengnan; Feng, Weisheng; Zheng, Xiaoke] Engn & Technol Ctr Chinese Med Dev Henan Prov, Zhengzhou 450046, Peoples R China.
C3 Henan University of Traditional Chinese Medicine
RP Feng, WS; Zheng, XK (corresponding author), Henan Univ Chinese Med, Dept Pharm, Zhengzhou 450046, Peoples R China.
EM fwsh@hactcm.edu.cn; zhengxk.2006@163.com
RI Zhang, Qi/N-4015-2019; 袁, 培培/HLG-8019-2023
FU National Key Research and Development Program (Major Project for
   Research of the Modernization of TCM) [2019YFC1708802]; Henan Province
   High-Level Personnel Special Support ('ZhongYuan One Thousand People
   Plan'; Zhongyuan Leading Talent) [ZYQR201810080]; Key Scientific
   Research Projects of Colleges and Universities of Henan Province
   [21A360014]
FX This work was supported by the National Key Research and Development
   Program (Major Project for Research of the Modernization of TCM;
   2019YFC1708802), Henan Province High-Level Personnel Special Support
   ('ZhongYuan One Thousand People Plan'; Zhongyuan Leading Talent
   (ZYQR201810080)), and Key Scientific Research Projects of Colleges and
   Universities of Henan Province (21A360014).
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NR 51
TC 2
Z9 2
U1 3
U2 6
PU CELL PRESS
PI CAMBRIDGE
PA 50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA
EI 2405-8440
J9 HELIYON
JI Heliyon
PD MAY 15
PY 2024
VL 10
IS 9
AR e29807
DI 10.1016/j.heliyon.2024.e29807
EA MAY 2024
PG 14
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA SX6S4
UT WOS:001237793400001
PM 38737244
OA gold
DA 2025-06-11
ER

PT J
AU Stepto, NK
   Moreno-Asso, A
   McIlvenna, LC
   Walters, KA
   Rodgers, RJ
AF Stepto, Nigel K.
   Moreno-Asso, Alba
   McIlvenna, Luke C.
   Walters, Kirsty A.
   Rodgers, Raymond J.
TI Molecular Mechanisms of Insulin Resistance in Polycystic Ovary Syndrome:
   Unraveling the Conundrum in Skeletal Muscle?
SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Article
ID MITOCHONDRIAL-FUNCTION; CARDIOMETABOLIC RISK; OBESE WOMEN; TGF-BETA;
   EXERCISE; ASSOCIATION; PREVALENCE; ANXIETY; OVERWEIGHT; PCOS
AB Context: Polycystic ovary syndrome (PCOS) is a common endocrine condition affecting 8% to 13% of women across the lifespan. PCOS affects reproductive, metabolic, and mental health, generating a considerable health burden. Advances in treatment of women with PCOS has been hampered by evolving diagnostic criteria and poor recognition by clinicians. This has resulted in limited clinical and basic research. In this study, we provide insights into the current and future research on the metabolic features of PCOS, specifically as they relate to PCOS-specific insulin resistance (IR), that may affect the most metabolically active tissue, skeletal muscle.
   Current Knowledge: PCOS is a highly heritable condition, yet it is phenotypically heterogeneous in both reproductive and metabolic features. Human studies thus far have not identified molecular mechanisms of PCOS-specific IR in skeletal muscle. However, recent research has provided new insights that implicate energy-sensing pathways regulated via epigenomic and resultant transcriptomic changes. Animal models, while in existence, have been underused in exploring molecular mechanisms of IR in PCOS and specifically in skeletal muscle.
   Future Directions: Based on the latest evidence synthesis and technologies, researchers exploring molecular mechanisms of IR in PCOS, specifically in muscle, will likely need to generate new hypothesis to be tested in human and animal studies.
   Conclusion: Investigations to elucidate the molecular mechanisms driving IR in PCOS are in their early stages, yet remarkable advances have been made in skeletal muscle. Overall, investigations have thus far created more questions than answers, which provide new opportunities to study complex endocrine conditions.
C1 [Stepto, Nigel K.; Moreno-Asso, Alba; McIlvenna, Luke C.] Victoria Univ, Inst Hlth & Sport, Footscray, Vic 8001, Australia.
   [Stepto, Nigel K.] Monash Univ, Monash Ctr Hlth Res & Implementat, Clayton, Vic 3168, Australia.
   [Stepto, Nigel K.] Monash Hlth, Clayton, Vic 3168, Australia.
   [Stepto, Nigel K.; Moreno-Asso, Alba] Victoria Univ, Australian Inst Musculoskeletal Sci, St Albans, Vic 3021, Australia.
   [Stepto, Nigel K.] Univ Melbourne, Fac Med Dent & Hlth Sci, Med Western Hlth, Melbourne, Vic 3010, Australia.
   [Walters, Kirsty A.] Univ New South Wales, Fac Med, Sch Womens & Childrens Hlth, Sydney, NSW 2031, Australia.
   [Rodgers, Raymond J.] Univ Adelaide, Robinson Res Inst, Adelaide, SA 5006, Australia.
C3 Victoria University; Monash University; Monash Health; Victoria
   University; Australian Institute for Musculoskeletal Science; University
   of Melbourne; University of New South Wales Sydney; University of
   Adelaide; Robinson Research Institute
RP Stepto, NK (corresponding author), Victoria Univ, Inst Hlth & Sport, POB 14428, Melbourne, Vic 8001, Australia.
EM nigel.stepto@vu.edu.au
RI Rodgers, Raymond/C-3476-2009; McIlvenna, Luke/AAC-9231-2019
OI Stepto, Nigel/0000-0002-0875-6836; McIlvenna, Luke/0000-0003-3759-3711;
   Moreno-Asso, Alba/0000-0003-1213-2572; Walters,
   Kirsty/0000-0002-1504-9734
FU National Health and Medical Research Council (NHMRC) Centre of Research
   Excellence in PCOS [APP1078444]; NHMRC [APP1156329, APP1158450,
   APP1022648]
FX The opinions expressed in this manuscript were informed by a substantial
   evidence synthesis from our National Health and Medical Research Council
   (NHMRC) Centre of Research Excellence in PCOS awarded to R.J.R. (CI) and
   N.K.S. and K.A.W. (AIs) (APP1078444). The associated research of N.K.S.
   and R.J.R. is supported by NHMRC Project Grant APP1156329, and the work
   of K.A.W. is supported by NHMRC Project Grants APP1158450 and
   APP1022648.
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NR 60
TC 40
Z9 44
U1 1
U2 13
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0021-972X
EI 1945-7197
J9 J CLIN ENDOCR METAB
JI J. Clin. Endocrinol. Metab.
PD NOV
PY 2019
VL 104
IS 11
BP 5369
EP 5378
DI 10.1210/jc.2019-00167
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA JP0RB
UT WOS:000497979600050
PM 30938770
OA Bronze
DA 2025-06-11
ER

PT J
AU Hosseini, A
   Razavi, BM
   Banach, M
   Hosseinzadeh, H
AF Hosseini, Azar
   Razavi, Bibi Marjan
   Banach, Maciej
   Hosseinzadeh, Hossein
TI Quercetin and metabolic syndrome: A review
SO PHYTOTHERAPY RESEARCH
LA English
DT Review
DE diabetes; dyslipidemia; hypertension; metabolic syndrome; obesity;
   quercetin
ID HIGH-FAT DIET; FLAVONOID QUERCETIN; CARDIOVASCULAR-DISEASE; OXIDATIVE
   STRESS; BLOOD-PRESSURE; INDUCED INFLAMMATION; LIPID-METABOLISM;
   DOUBLE-BLIND; RISK-FACTORS; ANTIOXIDANT
AB Metabolic syndrome (MetS) is a complex of diseases that lead to mortality due to the development of cardiovascular problems. Quercetin, as an important flavonoid, has various properties such as decreasing blood pressure, anti-hyperlipidemia, anti-hyperglycemia, anti-oxidant, antiviral, anticancer, anti-inflammatory, anti-microbial, neuroprotective, and cardio-protective effects. In this review article, we collected original articles from different sources such as Google Scholar, Medline, Scopus, and Pubmed, which is related to the effect of quercetin on the improvement of the signs of MetS, including elevated glucose level, hyperlipidemia, obesity, and blood pressure. According to these data, quercetin may also have a role in the management of metabolic disorders via different mechanisms such as increasing adiponectin, decreasing leptin, anti-oxidant activity, reduction of insulin resistance, the elevation of insulin level, and blocking of calcium channel. We have attempted to make some recommendations on the quercetin application in patients. However, it needs to do further clinical trials and more investigations to show the real clinical value of quercetin on metabolic syndrome.
C1 [Hosseini, Azar] Mashhad Univ Med Sci, Pharmacol Res Ctr Med Plants, Mashhad, Razavi Khorasan, Iran.
   [Razavi, Bibi Marjan] Mashhad Univ Med Sci, Targeted Drug Delivery Res Ctr, Pharmaceut Technol Inst, Mashhad, Razavi Khorasan, Iran.
   [Razavi, Bibi Marjan; Hosseinzadeh, Hossein] Mashhad Univ Med Sci, Sch Pharm, Dept Pharmacodynam & Toxicol, Mashhad, Razavi Khorasan, Iran.
   [Banach, Maciej] Med Univ Lodz, Dept Hypertens, Lodz, Poland.
   [Hosseinzadeh, Hossein] Mashhad Univ Med Sci, Pharmaceut Res Ctr, Pharmaceut Technol Inst, Mashhad, Razavi Khorasan, Iran.
C3 Mashhad University of Medical Sciences; Mashhad University of Medical
   Sciences; Mashhad University of Medical Sciences; Medical University
   Lodz; Mashhad University of Medical Sciences
RP Hosseinzadeh, H (corresponding author), Mashhad Univ Med Sci, Sch Pharm, Dept Pharmacodynam & Toxicol, Mashhad, Razavi Khorasan, Iran.
EM hosseinzadehh@mums.ac.ir
RI Hosseini, Azar/O-4753-2018; Banach, Maciej/A-1271-2009; razavi, Bibi
   Marjan/AAY-5636-2020; Hosseinzadeh, Hossein/F-3013-2010
OI Svirchev, Laurence/0000-0001-5652-0994; razavi, Bibi
   Marjan/0000-0002-7450-9286; Hosseinzadeh, Hossein/0000-0002-3483-851X
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NR 126
TC 231
Z9 246
U1 19
U2 119
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0951-418X
EI 1099-1573
J9 PHYTOTHER RES
JI Phytother. Res.
PD OCT
PY 2021
VL 35
IS 10
BP 5352
EP 5364
DI 10.1002/ptr.7144
EA JUN 2021
PG 13
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA WL6EZ
UT WOS:000658802700001
PM 34101925
HC Y
HP N
DA 2025-06-11
ER

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   diet-fed rats with metabolic syndrome
SO JOURNAL OF FUNCTIONAL FOODS
LA English
DT Article
DE High fat diets; Insulin resistance; Magnesium lithospermate B; Metabolic
   syndrome; Steatosis
ID SALVIA-MILTIORRHIZA; HEPATIC STEATOSIS; INHIBITORY-ACTIVITY;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; ACID; OBESITY; LIVER; MECHANISMS;
   CHEMISTRY
AB Danshen, the roots of Salvia miltiorrhiza, is a natural food and traditional Chinese herb possessing antidiabetic and antilipidaemic activities. In the present study, the beneficial effects and possible mechanisms of Magnesium lithospermate B (MLB), the major soluble constituent in Danshen, were investigated in a rodent model of metabolic syndrome induced by a high-fat diet (HFD). Daily supplementation of MLB improved obesity, hyperlipidaemia, hyperglycaemia, glucose intolerance, insulin resistance, and hepatic steatosis caused by HFD. Mechanistic studies showed that MLB caused a down-regulation of fatty acid transporter CD36 and lipogenic transcription factor sterol regulatory element-binding transcription factor 1c (SREBP1c) expression and an up-regulation of lipolytic transcription factor peroxisome proliferator-activated receptor-alpha (PPAR alpha) expression and post-receptor insulin signalling. In addition, MLB supplementation attenuated proinflammatory cytokine and adipokine expression. These results suggest that MLB may be an active ingredient contributing to the beneficial effects of Danshen on insulin resistance as well as on metabolic syndrome. (C) 2015 Elsevier Ltd. All rights reserved.
C1 [Chen, Ying-Jie; Lo, Yuan-Hao; Lin, Nan-Hei; Chung, Tse-Yu; Tzen, Jason T. C.] Natl Chung Hsing Univ, Grad Inst Biotechnol, Taichung 40027, Taiwan.
   [Chen, Yi-Ting; Lai, Nai-Wei; Chen, Wen-Ying] Natl Chung Hsing Univ, Dept Vet Med, Taichung 40027, Taiwan.
C3 National Chung Hsing University; National Chung Hsing University
RP Chen, WY (corresponding author), Natl Chung Hsing Univ, Dept Vet Med, Taichung 40027, Taiwan.
EM wychen@dragon.nchu.edu.tw; tctzen@dragon.nchu.edu.tw
RI Chen, WY/HKN-5931-2023
OI Tzen, Jason/0000-0002-4218-6363
FU National Chung-Hsing University [NCHU-102D604,
   NSC100-2313-B-005-012-MY3]; Ministry of Science and Technology, Taiwan
FX This study was supported by grants (NCHU-102D604 and
   NSC100-2313-B-005-012-MY3) from National Chung-Hsing University and
   Ministry of Science and Technology, Taiwan.
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NR 48
TC 13
Z9 13
U1 0
U2 24
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1756-4646
J9 J FUNCT FOODS
JI J. Funct. Food.
PD APR
PY 2015
VL 14
BP 163
EP 173
DI 10.1016/j.jff.2015.01.042
PG 11
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA CV8AX
UT WOS:000364500000017
DA 2025-06-11
ER

PT J
AU Solberg, SM
AF Solberg, Silje Michelsen
TI Psoriasis in Norway: a prescription-based registry study of
   psoriasis-associated comorbidities
SO EUROPEAN JOURNAL OF DERMATOLOGY
LA English
DT Article
DE psoriasis; comorbidities; cardiovascular disease; depression; anxiety;
   inflammatory bowel disease
ID METABOLIC SYNDROME; INCREASED RISK; PREVALENCE; HYPERTENSION;
   POPULATION; DISEASE; HUNT
AB BackgroundPsoriasis is an inflammatory skin disease, frequently associated with comorbidities.ObjectivesTo characterize comorbidities associated with skin psoriasis using real-world data.Materials & MethodsThe study was conducted in Norway, taking advantage of the universal healthcare system with equal access to healthcare and a mandatory prescription reporting system that applies to all hospitals and clinics. The study focused on patients registered in the Norwegian Prescription Database (NorPD) who had either a diagnosis code indicating skin psoriasis alone or in combination with diagnosis codes for pre-selected comorbidities.ResultsBetween 2004 and 2020, a total of 272,725 patients diagnosed with skin psoriasis were identified in NorPD, and 84,432 patients received their first prescription for skin psoriasis between 2015 and 2020. Among these, patients who received prescriptions for pre-selected comorbidities, either before or after initial prescription for psoriasis treatment, were included in the study. The most common prescriptions for patients with skin psoriasis were for primary prevention of atherosclerotic disease (22.6%), established atherosclerotic disease (19.3%), and depression (18.4%). These were closely followed by prescriptions for other comorbidities such as heart failure (16.1%), type II diabetes mellitus (9.4%), hypertension (9.4%), anxiety (7.8%), psoriatic arthritis (5.5%), acute myocardial infarction (4.2%), hypertensive cardiac disease (3.0%), ulcerative colitis (2.4%), type I diabetes mellitus (2.2%), secondary prophylaxis after myocardial infarction (1.6%), and Crohn's disease (1.0%).ConclusionPatients with skin psoriasis have a high number of prescriptions not only for their psoriasis but also for many other conditions compared to reports in the literature on the general population.
C1 [Solberg, Silje Michelsen] Haukeland Hosp, Dept Dermatol, Bergen, Norway.
   [Solberg, Silje Michelsen] Univ Bergen, Dept Clin Med, Bergen, Norway.
C3 University of Bergen; Haukeland University Hospital; University of
   Bergen
RP Solberg, SM (corresponding author), Haukeland Hosp, Dept Dermatol, Bergen, Norway.; Solberg, SM (corresponding author), Univ Bergen, Dept Clin Med, Bergen, Norway.
EM smso@helse-bergen.no
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NR 48
TC 2
Z9 2
U1 0
U2 0
PU JLE
PI ARCUEIL
PA 30, RUE BERTHOLLET, BATIMENT A, 94110 ARCUEIL, ?, FRANCE
SN 1167-1122
EI 1952-4013
J9 EUR J DERMATOL
JI Eur. J. Dermatol.
PD NOV
PY 2023
VL 33
IS 6
BP 657
EP 663
DI 10.1684/ejd.2023.4585
PG 7
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA NR1F5
UT WOS:001202082200013
PM 38465547
OA hybrid
DA 2025-06-11
ER

PT J
AU Dobre, D
   Schwan, R
   Jansen, C
   Schwitzer, T
   Martin, O
   Ligier, F
   Rolland, B
   Ahad, PA
   Capdevielle, D
   Corruble, E
   Delamillieure, P
   Dollfus, S
   Drapier, D
   Bennabi, D
   Joubert, F
   Lecoeur, W
   Massoubre, C
   Pelissolo, A
   Roser, M
   Schmitt, C
   Teboul, N
   Vansteene, C
   Yekhlef, W
   Yrondi, A
   Haoui, R
   Gaillard, R
   Leboyer, M
   Thomas, P
   Gorwood, P
   Laprevote, V
AF Dobre, Daniela
   Schwan, Raymund
   Jansen, Claire
   Schwitzer, Thomas
   Martin, Olivier
   Ligier, Fabienne
   Rolland, Benjamin
   Ahad, Pierre Abdel
   Capdevielle, Delphine
   Corruble, Emmanuelle
   Delamillieure, Pascal
   Dollfus, Sonia
   Drapier, Dominique
   Bennabi, Djamila
   Joubert, Fabien
   Lecoeur, William
   Massoubre, Catherine
   Pelissolo, Antoine
   Roser, Mathilde
   Schmitt, Christophe
   Teboul, Noe
   Vansteene, Clement
   Yekhlef, Wanda
   Yrondi, Antoine
   Haoui, Radoine
   Gaillard, Raphael
   Leboyer, Marion
   Thomas, Pierre
   Gorwood, Philip
   Laprevote, Vincent
TI Clinical features and outcomes of COVID-19 patients hospitalized for
   psychiatric disorders: a French multi-centered prospective observational
   study
SO PSYCHOLOGICAL MEDICINE
LA English
DT Article
DE Confusional state; COVID-19; mental health; psychiatry
ID METABOLIC SYNDROME; PREVALENCE; SCHIZOPHRENIA; MORTALITY; SMOKING;
   FRANCE; CARE; UK
AB Background Patients with psychiatric disorders are exposed to high risk of COVID-19 and increased mortality. In this study, we set out to assess the clinical features and outcomes of patients with current psychiatric disorders exposed to COVID-19. Methods This multi-center prospective study was conducted in 22 psychiatric wards dedicated to COVID-19 inpatients between 28 February and 30 May 2020. The main outcomes were the number of patients transferred to somatic care units, the number of deaths, and the number of patients developing a confusional state. The risk factors of confusional state and transfer to somatic care units were assessed by a multivariate logistic model. The risk of death was analyzed by a univariate analysis. Results In total, 350 patients were included in the study. Overall, 24 (7%) were transferred to medicine units, 7 (2%) died, and 51 (15%) patients presented a confusional state. Severe respiratory symptoms predicted the transfer to a medicine unit [odds ratio (OR) 17.1; confidence interval (CI) 4.9-59.3]. Older age, an organic mental disorder, a confusional state, and severe respiratory symptoms predicted mortality in univariate analysis. Age >55 (OR 4.9; CI 2.1-11.4), an affective disorder (OR 4.1; CI 1.6-10.9), and severe respiratory symptoms (OR 4.6; CI 2.2-9.7) predicted a higher risk, whereas smoking (OR 0.3; CI 0.1-0.9) predicted a lower risk of a confusional state. Conclusion COVID-19 patients with severe psychiatric disorders have multiple somatic comorbidities and have a risk of developing a confusional state. These data underline the need for extreme caution given the risks of COVID-19 in patients hospitalized for psychiatric disorders.
C1 [Dobre, Daniela; Schwan, Raymund; Jansen, Claire; Schwitzer, Thomas; Martin, Olivier; Ligier, Fabienne; Laprevote, Vincent] Ctr Psychotherap Nancy, F-54520 Laxou, France.
   [Dobre, Daniela; Schwan, Raymund; Schwitzer, Thomas; Laprevote, Vincent] Ctr Hosp Reg Univ Strasbourg, Dept Psychiat, Federat Med Translat Strasbourg, INSERM U1114, F-67000 Strasbourg, France.
   [Schwan, Raymund; Jansen, Claire; Schwitzer, Thomas; Ligier, Fabienne; Laprevote, Vincent] Univ Lorraine, Fac Med, F-54500 Vandoeuvre Les Nancy, France.
   [Ligier, Fabienne] Univ Lorraine, EA 4360 APEMAC, F-54500 Vandoeuvre Les Nancy, France.
   [Rolland, Benjamin] CH Le Vinatier, Serv Univ Addictol Lyon SUAL, Bron, France.
   [Rolland, Benjamin] Hosp Civils Lyon, Serv Hosp Univ Addictol, Lyon, France.
   [Rolland, Benjamin] Univ Lyon, Ctr Rech Neurosci Lyon CRNL, PSYR2, CNRS UMR5292,UCBL,INSERM U1028, Bron, France.
   [Ahad, Pierre Abdel; Gaillard, Raphael] GHU Paris Psychiat & Neurosci, Pole Hosp Univ Psychiat Adultes Paris 15Eme, Site St Anne, Paris, France.
   [Capdevielle, Delphine] Univ Montpellier, INSERM, CNRS, IGF, Montpellier, France.
   [Capdevielle, Delphine] CHU, Univ Dept Adult Psychiat, Montpellier, France.
   [Corruble, Emmanuelle] CHU Montpellier, Univ Dept Adult Psychiat, Hop La Colombiere, Montpellier, France.
   [Corruble, Emmanuelle] Hop Univ Paris Saciay, Serv Hosp Univ Psychiat Bicetre, Hop Bicetre, Assistance Publ Hop Paris, F-94275 Le Kremlin Bicetre, France.
   [Delamillieure, Pascal; Dollfus, Sonia] CHU Caen, Serv Psychiat, Ctr Esquirol, F-14000 Caen, France.
   [Delamillieure, Pascal; Dollfus, Sonia] Normandie Univ, GIP Cyceron, Imagerie & Strategies Therapeut Schizophrenie EA, F-14000 Caen, France.
   [Delamillieure, Pascal; Dollfus, Sonia] Normandie Univ, UFR Sante, F-14000 Caen, France.
   [Drapier, Dominique] Ctr Hosp Guillaume Regnier, Pole Hosp Univ Psychiat Adulte, F-35703 Rennes, France.
   [Drapier, Dominique] Univ Rennes 1, EA 47 12 Comportement & Noyaux Gris Cent, F-35703 Rennes, France.
   [Bennabi, Djamila] CHRU Besancon, Serv Psychiat Adulte, F-25000 Besancon, France.
   [Bennabi, Djamila] Ctr Expert Depress Resistante FondaMental, F-25000 Besancon, France.
   [Joubert, Fabien; Teboul, Noe] CH Le Vinatier, Dept Informat Med, Bron, France.
   [Lecoeur, William] Etab Publ Sante Alsace Nord, Brumath, France.
   [Massoubre, Catherine] CHU St Etienne, Serv Univ Psychiat, EA TAPE 7423, St Etienne, France.
   [Pelissolo, Antoine; Roser, Mathilde; Leboyer, Marion] Univ Paris Est, Fac Med, UPEC, F-94000 Creteil, France.
   [Pelissolo, Antoine; Roser, Mathilde; Leboyer, Marion] Hop Univ Henri Mondor, AP HP, DMU IMPACT, Serv Psychiat, F-94000 Creteil, France.
   [Pelissolo, Antoine; Roser, Mathilde; Leboyer, Marion] INSERM U955, Lab Neuropsychiat Translat, F-94000 Creteil, France.
   [Schmitt, Christophe] Ctr Hosp Jury, Dept Informat Med, F-57073 Metz, France.
   [Vansteene, Clement; Gorwood, Philip] Hop St Anne, Clin Malad Mentales & Encephale CMME, 1 Rue Cabanis, F-75014 Paris, France.
   [Vansteene, Clement] Univ Paris 05, Ctr Psychiat & Neurosci CPN, PRES Sorbonne Paris Cite, INSERM U894, Paris, France.
   [Yekhlef, Wanda] EPS Ville Evrard, Pole CRISTALES, Dept Soins Somat Prevent Sante Publ, Neuilly Sur Marne, France.
   [Yrondi, Antoine] CHU Toulouse, Serv Psychiat & Psychol Med, Hop Purpan, Ctr Expert Depress Resistante FondaMental, Toulouse, France.
   [Yrondi, Antoine] Univ Toulouse, ToNIC Toulouse NeuroImaging Ctr, UPS, INSERM, Toulouse, France.
   [Haoui, Radoine] Ctr Hosp Gerard Marchant, Pole Psychiat Gen Rive Gauche, F-31057 Toulouse, France.
   [Gaillard, Raphael] Univ Paris, Paris, France.
   [Gaillard, Raphael] Inst Pasteur, Infect & Epidemiol Dept, Human Histopathol & Anim Models, Paris, France.
   [Thomas, Pierre] Univ Lille, INSERM U1172, CHU Lille, Ctr Lille Neurosci & Cognit PSY, F-59000 Lille, France.
   [Thomas, Pierre] CHU Lille, Pole Psychiat, F-59000 Lille, France.
   [Gorwood, Philip] Univ Paris, Inst Psychiat & Neurosci Paris, INSERM U1266, Paris, France.
   [Gorwood, Philip] Hop St Anne, GHU Paris Psychiat & Neurosci, CMME, Paris, France.
C3 Institut National de la Sante et de la Recherche Medicale (Inserm); CHU
   Strasbourg; Universites de Strasbourg Etablissements Associes;
   Universite de Strasbourg; Universite de Lorraine; Universite de
   Lorraine; CHU Lyon; Centre National de la Recherche Scientifique (CNRS);
   CNRS - National Institute for Biology (INSB); Institut National de la
   Sante et de la Recherche Medicale (Inserm); Universite Claude Bernard
   Lyon 1; Universite Jean Monnet; Universite Paris Cite; GHU PARIS
   Psychiatrie Neurosciences; Institut National de la Sante et de la
   Recherche Medicale (Inserm); Centre National de la Recherche
   Scientifique (CNRS); Universite de Montpellier; Universite de
   Montpellier; CHU de Montpellier; Universite de Montpellier; CHU de
   Montpellier; Assistance Publique Hopitaux Paris (APHP); Hopital
   Universitaire Bicetre - APHP; Universite Paris Cite; Hopital
   Universitaire Saint-Louis - APHP; Universite Paris Saclay; Hopital
   Universitaire Antoine-Beclere - APHP; CHU de Caen NORMANDIE; Universite
   de Caen Normandie; Institut National de la Sante et de la Recherche
   Medicale (Inserm); Universite de Caen Normandie; CHU Rennes; Universite
   de Rennes; Universite de Franche-Comte; CHU Besancon; CHU de St Etienne;
   Universite Paris-Est-Creteil-Val-de-Marne (UPEC); Universite
   Paris-Est-Creteil-Val-de-Marne (UPEC); Assistance Publique Hopitaux
   Paris (APHP); Hopital Universitaire Henri-Mondor - APHP; Institut
   National de la Sante et de la Recherche Medicale (Inserm); Universite
   Paris-Est-Creteil-Val-de-Marne (UPEC); Universite Paris Cite; GHU PARIS
   Psychiatrie Neurosciences; Universite Paris Cite; Institut National de
   la Sante et de la Recherche Medicale (Inserm); Universite de Toulouse;
   Universite Toulouse III - Paul Sabatier; CHU de Toulouse; Institut
   National de la Sante et de la Recherche Medicale (Inserm); Universite de
   Toulouse; Universite Toulouse III - Paul Sabatier; Universite Paris
   Cite; Pasteur Network; Universite Paris Cite; Institut Pasteur Paris;
   Universite de Lille; CHU Lille; Institut National de la Sante et de la
   Recherche Medicale (Inserm); Universite de Lille; CHU Lille; Institut
   National de la Sante et de la Recherche Medicale (Inserm); Universite
   Paris Cite; Universite Paris Cite; GHU PARIS Psychiatrie Neurosciences
RP Laprevote, V (corresponding author), Ctr Psychotherap Nancy, F-54520 Laxou, France.; Laprevote, V (corresponding author), Ctr Hosp Reg Univ Strasbourg, Dept Psychiat, Federat Med Translat Strasbourg, INSERM U1114, F-67000 Strasbourg, France.; Laprevote, V (corresponding author), Univ Lorraine, Fac Med, F-54500 Vandoeuvre Les Nancy, France.
EM vincent.laprevote@cpn-laxou.com
RI Schwitzer, Thomas/AAA-2067-2022; GORWOOD, Philip/M-9703-2019; Dollfus,
   Sonia/L-4551-2013; Capdevielle, Delphine/HTO-4229-2023; ROLLAND,
   Benjamin/H-6625-2019; SCHMITT, Christophe/AAL-3551-2021; Martin,
   Olivier/F-3775-2011; djamila, bennabi/AAI-7456-2020; ROLLAND,
   Benjamin/E-7374-2013
OI ROLLAND, Benjamin/0000-0002-8666-3635; laprevote,
   vincent/0000-0003-4471-0330; Yrondi, Antoine/0000-0002-2650-6080;
   GORWOOD, Philip/0000-0003-1845-3676; Bennabi,
   Djamila/0000-0001-5080-2501
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NR 47
TC 0
Z9 0
U1 1
U2 5
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0033-2917
EI 1469-8978
J9 PSYCHOL MED
JI Psychol. Med.
PD JAN
PY 2023
VL 53
IS 2
BP 342
EP 350
AR PII S0033291721001537
DI 10.1017/S0033291721001537
EA APR 2021
PG 9
WC Psychology, Clinical; Psychiatry; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA 8S0JR
UT WOS:000786963000001
PM 33902760
OA Green Published
DA 2025-06-11
ER

PT J
AU Jirakran, K
   Vasupanrajit, A
   Tunvirachaisakul, C
   Almulla, AF
   Kubera, M
   Maes, M
AF Jirakran, Ketsupar
   Vasupanrajit, Asara
   Tunvirachaisakul, Chavit
   Almulla, Abbas F.
   Kubera, Marta
   Maes, Michael
TI Lipid profiles in major depression, both with and without metabolic
   syndrome: associations with suicidal behaviors and neuroticism
SO BMC PSYCHIATRY
LA English
DT Article
DE Major depression; Lipids; Reverse cholesterol transport; Mood disorders;
   Atherogenicity; Cardiovascular disease
ID HIGH-DENSITY-LIPOPROTEIN; BIPOLAR-DISORDER; CARDIOVASCULAR-DISEASE;
   INSULIN-RESISTANCE; RATING-SCALE; CHOLESTEROL; RISK; MORTALITY; HDL;
   INFLAMMATION
AB BackgroundSignificant associations exist between major depressive disorder (MDD), metabolic syndrome (MetS), and cardiovascular disease, potentially attributable to heightened atherogenicity. This study aimed to ascertain if MDD, depression severity, suicidal behaviors, and neuroticism associate with elevated pro-atherogenic indices and reduced anti-atherogenic indices, including a reverse cholesterol transport (RCT) index.MethodsThis study comprised 34 healthy controls and 33 MDD patients without MetS, and 35 controls and 31 MDD patients with MetS. It assessed total cholesterol (TC) and free cholesterol (FC), high-density lipoprotein cholesterol (HDLc), low-density lipoprotein cholesterol (LDLc), triglycerides (TG), apolipoprotein (ApoA), ApoB, cholesterol esterification rate, and a RCT composite.ResultsNo significant associations between MDD and lipids were seen in the total study group that combined individuals with and without MetS. In individuals devoid of MetS, MDD is significantly correlated with (a) elevated FC, TG, ApoB, Castelli risk index 1, and ApoB/ApoA, and (b) diminished HDLc, ApoA, and RCT index. In individuals without MetS, there are notable correlations between the severity of depression, suicidal tendencies, neuroticism, and ApoB/ApoA, Castelli risk, and RCT indices.ConclusionsThe link between lipids and MDD features cannot be adequately estimated by combining participants with and without MetS. It should be examined in a study sample that excludes subjects with MetS. The depression phenome, suicidal behaviors, and neuroticism correlate with diminished RCT and heightened atherogenicity, which are likely implicated in the pathophysiology of MDD. Increased atherogenicity and lowered RCT may represent novel drug targets for the treatment and prevention of MDD, neuroticism, and suicidal behaviors.
C1 [Jirakran, Ketsupar; Almulla, Abbas F.; Maes, Michael] Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Sichuan Prov Ctr Mental Hlth, Sch Med, Chengdu 610072, Peoples R China.
   [Jirakran, Ketsupar; Almulla, Abbas F.; Maes, Michael] Chinese Acad Med Sci, Key Lab Psychosomat Med, Chengdu 610072, Peoples R China.
   [Jirakran, Ketsupar; Vasupanrajit, Asara; Tunvirachaisakul, Chavit; Almulla, Abbas F.; Maes, Michael] Chulalongkorn Univ, Fac Med, Dept Psychiat, Bangkok, Thailand.
   [Jirakran, Ketsupar; Vasupanrajit, Asara; Tunvirachaisakul, Chavit; Almulla, Abbas F.; Maes, Michael] King Chulalongkorn Mem Hosp, Thai Red Cross Societyaq, Bangkok, Thailand.
   [Jirakran, Ketsupar] Chulalongkorn Univ, Fac Med, Ctr Excellence Maximizing Childrens Dev Potential, Dept Pediat, Bangkok, Thailand.
   [Tunvirachaisakul, Chavit; Maes, Michael] Chulalongkorn Univ, Fac Med, Cognit Impairment & Dementia Res Unit, Bangkok, Thailand.
   [Almulla, Abbas F.] Islamic Univ, Coll Med Technol, Med Lab Technol Dept, Najaf, Iraq.
   [Kubera, Marta] Polish Acad Sci, Maj Inst Pharmacol, Dept Expt Neuroendocrinol, Lab Immunoendocrinol, Smetna 12, PL-31343 Krakow, Poland.
   [Maes, Michael] Med Univ Plovdiv, Dept Psychiat, Plovdiv, Bulgaria.
   [Maes, Michael] Med Univ Plovdiv, Res Ctr, Plovdiv, Bulgaria.
   [Maes, Michael] EU, Creat Network Res Higher Sch, Res & Innovat Program Dev MU PLOVDIV SRIPD MUP, Natl Plan Recovery & Sustainabil,European Union Ne, Maastricht, Netherlands.
   [Maes, Michael] Kyung Hee Univ, 26 Kyungheedae Ro, Seoul 02447, South Korea.
C3 University of Electronic Science & Technology of China; Sichuan
   Provincial People's Hospital; Chinese Academy of Medical Sciences -
   Peking Union Medical College; Chulalongkorn University; Chulalongkorn
   University; Chulalongkorn University; Chulalongkorn University; Islamic
   University College; Polish Academy of Sciences; Maj Institute of
   Pharmacology of the Polish Academy of Sciences; Medical University
   Plovdiv; Medical University Plovdiv; Kyung Hee University
RP Maes, M (corresponding author), Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Sichuan Prov Ctr Mental Hlth, Sch Med, Chengdu 610072, Peoples R China.; Maes, M (corresponding author), Chinese Acad Med Sci, Key Lab Psychosomat Med, Chengdu 610072, Peoples R China.; Tunvirachaisakul, C; Maes, M (corresponding author), Chulalongkorn Univ, Fac Med, Dept Psychiat, Bangkok, Thailand.; Tunvirachaisakul, C; Maes, M (corresponding author), King Chulalongkorn Mem Hosp, Thai Red Cross Societyaq, Bangkok, Thailand.; Tunvirachaisakul, C; Maes, M (corresponding author), Chulalongkorn Univ, Fac Med, Cognit Impairment & Dementia Res Unit, Bangkok, Thailand.; Maes, M (corresponding author), Med Univ Plovdiv, Dept Psychiat, Plovdiv, Bulgaria.; Maes, M (corresponding author), Med Univ Plovdiv, Res Ctr, Plovdiv, Bulgaria.; Maes, M (corresponding author), EU, Creat Network Res Higher Sch, Res & Innovat Program Dev MU PLOVDIV SRIPD MUP, Natl Plan Recovery & Sustainabil,European Union Ne, Maastricht, Netherlands.; Maes, M (corresponding author), Kyung Hee Univ, 26 Kyungheedae Ro, Seoul 02447, South Korea.
EM chavit.t@chula.ac.th; dr.michaelmaes@hotmail.com
RI Vasupanrajit, Asara/ABG-5437-2021; Maes, Michael/B-8546-2011; Almulla,
   Abbas F./ABG-7926-2020
FU Faculty of Medicine, Chulalongkorn University; Center for Medical
   Diagnostic Laboratories Faculty of Medicine Chulalongkorn
   University/King Chulalongkorn Memorial Hospital [RA64/021];
   Ratchadapiseksompotch Fund, Graduate Affairs, Faculty of Medicine,
   Chulalongkorn University; CU Graduate School Thesis Grant; Graduate
   School, Chulalongkorn University
FX We are grateful to all participants who participated in this study,
   nurses, and staff at department of Psychiatry King Chulalongkorn
   Memorial Hospital, the Thai Red Cross Society, who helped recruit our
   participants, and Center for Medical Diagnostic Laboratories Faculty of
   Medicine Chulalongkorn University/King Chulalongkorn Memorial Hospital.
   This work was supported by the grant from Ratchadapiseksompotch Fund,
   Graduate Affairs, Faculty of Medicine, Chulalongkorn University (grant
   numbers RA64/021), Bangkok, Thailand. KJ scholarship from CU Graduate
   School Thesis Grant and the scholarship from Graduate School,
   Chulalongkorn University to Commemorate the 72nd anniversary of his
   Majesty King Bhumibol Adulyadej is gratefully acknowledged.
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NR 75
TC 0
Z9 0
U1 2
U2 2
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-244X
J9 BMC PSYCHIATRY
JI BMC Psychiatry
PD APR 15
PY 2025
VL 25
IS 1
AR 379
DI 10.1186/s12888-025-06734-2
PG 16
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychiatry
GA 1KR7T
UT WOS:001467315900003
PM 40234788
OA gold
DA 2025-06-11
ER

PT J
AU Tran, LT
   Yuen, VG
   McNeill, JH
AF Tran, Linda T.
   Yuen, Violet G.
   McNeill, John H.
TI The fructose-fed rat: a review on the mechanisms of fructose-induced
   insulin resistance and hypertension
SO MOLECULAR AND CELLULAR BIOCHEMISTRY
LA English
DT Review
DE Fructose-fed rat; Insulin resistance; Hypertension; Metabolic syndrome
ID DEPENDENT VASCULAR RELAXATION; CONVERTING ENZYME-INHIBITOR; PREVENTS
   ENDOTHELIAL DYSFUNCTION; RENIN-ANGIOTENSIN SYSTEM; AT(1) RECEPTOR
   DENSITY; BLOOD-PRESSURE; METABOLIC SYNDROME; NITRIC-OXIDE; OXIDATIVE
   STRESS; GLUCOSE-METABOLISM
AB The metabolic syndrome is an important public health concern that predisposes individuals to the development of cardiovascular disease and/or Type 2 diabetes. The fructose-fed rat is an animal model of acquired systolic hypertension that displays numerous features of the metabolic syndrome. This animal model is used to study the relationship between insulin resistance/compensatory hyperinsulinemia and the development of hypertension. Several mechanisms have been proposed to mediate the link between insulin resistance and hypertension. In this review, we have addressed the role of sympathetic nervous system overactivation, increased production of vasoconstrictors, such as endothelin-1 and angiotensin II, and prostanoids in the development of hypertension in fructose-fed rats. The roles of nitric oxide, impaired endothelium-dependent relaxation and sex hormones in the pathogenesis of the fructose-fed induced hypertensive rats have also been highlighted. More recently, increased formation of reactive oxygen species and elevated levels of uric acid have been reported to contribute to fructose-induced hypertension.
C1 [Tran, Linda T.; Yuen, Violet G.; McNeill, John H.] Univ British Columbia, Div Pharmacol & Toxicol, Fac Pharmaceut Sci, Vancouver, BC V6T 1Z3, Canada.
C3 University of British Columbia
RP McNeill, JH (corresponding author), Univ British Columbia, Div Pharmacol & Toxicol, Fac Pharmaceut Sci, 2146 East Mall, Vancouver, BC V6T 1Z3, Canada.
EM jmcneill@interchange.ubc.ca
FU Canadian Institutes of Health Research Funding Source: Medline
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NR 174
TC 289
Z9 334
U1 0
U2 33
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0300-8177
EI 1573-4919
J9 MOL CELL BIOCHEM
JI Mol. Cell. Biochem.
PD DEC
PY 2009
VL 332
IS 1-2
BP 145
EP 159
DI 10.1007/s11010-009-0184-4
PG 15
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA 515WK
UT WOS:000271503400018
PM 19536638
DA 2025-06-11
ER

PT J
AU Murphy, DL
   Lesch, KP
AF Murphy, Dennis L.
   Lesch, Klaus-Peter
TI Targeting the murine serotonin transporter: insights into human
   neurobiology
SO NATURE REVIEWS NEUROSCIENCE
LA English
DT Review
ID KNOCK-OUT MICE; PROMOTER POLYMORPHISM; NEUROENDOCRINE RESPONSES;
   PULMONARY-HYPERTENSION; DEPRESSIVE SYMPTOMS; EMOTION REGULATION; GENE
   POLYMORPHISM; BACTERIAL HOMOLOG; 5-HT2C RECEPTORS; COCAINE REWARD
AB Mutations resulting in reduced or completely abrogated serotonin-transporter (SERT) function in mice have led to the identification of more than 50 different phenotypic changes, ranging from increased anxiety and stress-related behaviours to gut dysfunction, bone weakness and late-onset obesity with metabolic syndrome. These multiple effects, which can be amplified by gene-environment and gene-gene interactions, are primarily attributable to altered intracellular and extracellular serotonin concentrations during development and adulthood. Much of the human data relating to altered expression of the gene that encodes SERT are based on genetic-association findings or correlations and are therefore not as robust as the experimental mouse results. Nevertheless, SERT-function-modifying gene variants in humans apparently produce many phenotypes that are similar to those that manifest themselves in mice.
C1 [Murphy, Dennis L.] NIMH, NIH, Lab Clin Sci Intramural Res Program, Bethesda, MD 20892 USA.
   [Lesch, Klaus-Peter] Univ Wurzburg, Dept Psychiat & Psychotherapy, D-97080 Wurzburg, Germany.
C3 National Institutes of Health (NIH) - USA; NIH National Institute of
   Mental Health (NIMH); University of Wurzburg
RP Murphy, DL (corresponding author), NIMH, NIH, Lab Clin Sci Intramural Res Program, Bethesda, MD 20892 USA.
EM DennisMurphy@mail.nih.gov; kplesch@mail.uni-wuerzburg.de
RI Lesch, Klaus-Peter/J-4906-2013
OI Lesch, Klaus-Peter/0000-0001-8348-153X
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NR 131
TC 365
Z9 418
U1 2
U2 38
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1471-003X
EI 1471-0048
J9 NAT REV NEUROSCI
JI Nat. Rev. Neurosci.
PD FEB
PY 2008
VL 9
IS 2
BP 85
EP 96
DI 10.1038/nrn2284
PG 12
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 253FE
UT WOS:000252503300011
PM 18209729
DA 2025-06-11
ER

PT J
AU Késöi, I
   Sági, B
   Vas, T
   Kovács, T
   Wittmann, I
   Nagy, J
AF Kesoi, Istvan
   Sagi, Balazs
   Vas, Tibor
   Kovacs, Tibor
   Wittmann, Istvan
   Nagy, Judit
TI Heart rate recovery after exercise is associated with renal function in
   patients with a homogenous chronic renal disease
SO NEPHROLOGY DIALYSIS TRANSPLANTATION
LA English
DT Article
DE cardiovascular risk; chronic kidney disease; heart rate recovery; IgA
   nephropathy; metabolic syndrome
ID METABOLIC SYNDROME; KIDNEY-DISEASE; PREDICTOR; MORTALITY; CAPACITY; MEN
AB Background. Attenuated heart rate recovery (HRR) is an independent predictor of cardiac and totalmortality. Diminished renal function is a similar predictor. There are no data concerning the interaction between the two risk factors. We studied HRR in patients with a homogeneous renal disease, IgA nephropathy.
   Methods. One hundred and seven patients with biopsy-proven chronic IgA nephropathy (71 males, 36 females aged 45 +/- 11 years) performed a graded exercise treadmill stress test. HRR was measured as the heart rate difference between the peak value and the heart rate 1 min after exercise. The patients were divided into three groups based on estimated glomerular filtration rate (eGFR): CKD 1, eGFR >= 90 ml/min (n = 46); CKD 2, eGFR 60-89 ml/min (n = 38), CKD 3-4, eGFR 15-59 ml/min (n = 23). We compared these data with 29 normal controls (aged 46 +/- 14 years).
   Results. HRR values corresponded to eGFR as follows: 29.9 +/- 8.8 bpm normal controls, 27.8 +/- 9.2 bpm CKD 1, 24.5 +/- 10.5 bpm CKD 2 and 16.3 +/- 9.3 bpm CKD 3-4. The latter differed from the other groups significantly (P < 0.05). Metabolic syndrome was common in IgA nephropathy patients (27%). Metabolic syndrome patients had a HRR of 19.6 +/- 10.1 bpm, compared to 25.8 +/- 10.4 bpm in patients without metabolic syndrome (P = 0.007). Nevertheless, a multivariate regression analysis accepted only eGFR as an independent predictor of HRR.
   Conclusion. eGFR predicts HRR in patients with a homogenous renal disease. Metabolic syndrome influences HRR, albeit not independently in this cohort.
C1 [Nagy, Judit] Univ Pecs, Fac Med, Nephrol Ctr, Pecs, Hungary.
   Univ Pecs, Fac Med, Dept Internal Med 2, Pecs, Hungary.
C3 University of Pecs; University of Pecs
RP Nagy, J (corresponding author), Univ Pecs, Fac Med, Nephrol Ctr, Pecs, Hungary.
EM judit.nagy@aok.pte.hu
OI Nagy, Judit/0000-0003-1702-5071
CR Ali Kizilbash M, 2006, EUR HEART J, V27, P1592, DOI 10.1093/eurheartj/ehl043
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NR 26
TC 10
Z9 12
U1 0
U2 3
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0931-0509
EI 1460-2385
J9 NEPHROL DIAL TRANSPL
JI Nephrol. Dial. Transplant.
PD FEB
PY 2010
VL 25
IS 2
BP 509
EP 513
DI 10.1093/ndt/gfp504
PG 5
WC Transplantation; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Transplantation; Urology & Nephrology
GA 547LY
UT WOS:000273891600031
PM 19783602
OA Bronze
DA 2025-06-11
ER

PT J
AU Vlachopoulos, C
   Rokkas, K
   Ioakeimidis, N
   Stefanadis, C
AF Vlachopoulos, Charalambos
   Rokkas, Konstantinos
   Ioakeimidis, Nikolaos
   Stefanadis, Christodoulos
TI Inflammation, metabolic syndrome, erectile dysfunction, and coronary
   artery disease: Common links
SO EUROPEAN UROLOGY
LA English
DT Review
DE erectile dysfunction; coronary artery disease; metabolic syndrome;
   inflammation
ID C-REACTIVE PROTEIN; RISK-FACTORS; ENDOTHELIAL DYSFUNCTION; SYSTEMIC
   INFLAMMATION; NITRIC-OXIDE; CAROTID ATHEROSCLEROSIS; ADHESION MOLECULES;
   GENERAL-POPULATION; INSULIN-RESISTANCE; OXIDATIVE STRESS
AB Objective: Erectile dysfunction (ED) may be the early clinical manifestation of a generalized vascular disease and carries an independent risk for cardiovascular events. Low-grade subclinical inflammation affects endothelial function and is involved in all stages of the atherosclerotic process. This review identifies potential pathophysiologic links among low-grade inflammation, ED, metabolic syndrome, and coronary artery disease (CAD) and presents the clinical implications in terms of ED diagnosis, assessment of patient risk, and therapy.
   Methods: A comprehensive evaluation was performed for available published data in full-length papers that were identified in MedLine up to July 2007.
   Results: Studies support an association between metabolic syndrome, ED, and increased inflammatory state. Increased circulating levels of inflammatory and endothelial-prothrombotic compounds are related to the presence and severity of ED. Specific inflammatory biomarkers and their combination appear to have the potential to aid ED diagnosis or exclusion. ED and CAD may confer a similar unfavorable impact on the inflammatory and prothrombotic state, whereas ED adds an incremental activation on top of CAD; these findings have important implications for cardiovascular risk. Lifestyle and risk factor modification, as well as pharmacologic therapy, are associated with anti-inflammatory effects.
   Conclusions: Low-grade systemic inflammation could be an important element of the association between metabolic syndrome, ED, and CAD. Its individualized assessment may be a valuable tool for ED diagnosis, risk assessment, and rationalized therapeutic approach especially in patients with ED who have metabolic syndrome and carry an intermediate risk for future cardiovascular events. (c) 2007 European Association of Urology. Published by Elsevier B.V. All rights reserved.
C1 Hippokrateion Hosp, Sch Med, Dept Cardiol 1, Cardiovasc Dis & Sexual Hlth Unit, Athens, Greece.
C3 Hippokration General Hospital; Athens Medical School; National &
   Kapodistrian University of Athens
RP Vlachopoulos, C (corresponding author), Hippokrateion Hosp, Sch Med, Dept Cardiol 1, Cardiovasc Dis & Sexual Hlth Unit, Athens, Greece.
EM cvlachop@otenet.gr
RI Stefanadis, Christodoulos/ABH-2232-2020
OI Stefanadis, Christodoulos/0000-0001-5974-6454
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NR 75
TC 195
Z9 214
U1 0
U2 9
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0302-2838
EI 1873-7560
J9 EUR UROL
JI Eur. Urol.
PD DEC
PY 2007
VL 52
IS 6
BP 1590
EP 1600
DI 10.1016/j.eururo.2007.08.004
PG 11
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 237XL
UT WOS:000251409600013
PM 17707576
DA 2025-06-11
ER

PT J
AU Johnson, RJ
   Rivard, C
   Lanaspa, MA
   Otabachian-Smith, S
   Ishimoto, T
   Cicerchi, C
   Cheeke, PR
   McIntosh, B
   Hess, T
AF Johnson, Richard J.
   Rivard, Chris
   Lanaspa, Miguel A.
   Otabachian-Smith, Silvia
   Ishimoto, Takuji
   Cicerchi, Christina
   Cheeke, Peter R.
   McIntosh, Bridgett
   Hess, Tanja
TI Fructokinase, Fructans, Intestinal Permeability, and Metabolic Syndrome:
   An Equine Connection?
SO JOURNAL OF EQUINE VETERINARY SCIENCE
LA English
DT Review
DE Fructose; Fructans; Fructokinase; Laminitis; Equine metabolic syndrome
ID EXCESSIVE FRUCTOSE INTAKE; DIET-INDUCED OBESITY; URIC-ACID; MICROBIAL
   ECOLOGY; BROILER-CHICKENS; INSULIN SENSITIVITY; GROWTH-PERFORMANCE;
   BACILLUS-SUBTILIS; GUT MICROBIOME; LAMINITIS
AB Fructose is a simple sugar present in honey and fruits, but can also exist as a polymer (fructans) in pasture grasses. Mammals are unable to metabolize fructans, but certain gram-positive bacteria contain fructanases and can convert fructans to fructose in the gut. Recent studies suggest that fructose generated from bacteria or directly obtained from the diet can induce both increased intestinal permeability and features of metabolic syndrome, especially the development of insulin resistance. The development of insulin resistance is driven in part by the metabolism of fructose by fructokinase C in the liver, which results in oxidative stress in the hepatocyte. Similarly, the metabolism of fructose in the small bowel by intestinal fructokinase may lead to increased intestinal permeability and endotoxemia. Although speculative, these observations raise the possibility that the mechanism by which fructans induce laminitis could involve intestinal and hepatic fructokinase. Further studies are indicated to determine the role of fructanases, fructose, and fructokinase in equine metabolic syndrome and laminitis. Published by Elsevier Inc.
C1 [Johnson, Richard J.; Rivard, Chris; Lanaspa, Miguel A.; Ishimoto, Takuji; Cicerchi, Christina] Univ Colorado, Div Renal Dis & Hypertens, Aurora, CO 80045 USA.
   [Otabachian-Smith, Silvia; Hess, Tanja] Colorado State Univ, Ft Collins, CO 80523 USA.
   [Cheeke, Peter R.] Oregon State Univ, Dept Anim Sci, Corvallis, OR 97331 USA.
   [McIntosh, Bridgett] Virginia Polytech Inst & State Univ, Middleburg, VA USA.
C3 University of Colorado System; University of Colorado Anschutz Medical
   Campus; Colorado State University System; Colorado State University Fort
   Collins; Oregon State University; Virginia Polytechnic Institute & State
   University
RP Johnson, RJ (corresponding author), Univ Colorado, Div Renal Dis & Hypertens, Mail Stop C281, Aurora, CO 80045 USA.
EM richard.johnson@ucdenver.edu
RI Lanaspa, Miguel/AAO-4971-2020; Ishimoto, Takuji/M-4873-2014
OI Ishimoto, Takuji/0000-0002-9861-5331
FU NIH [HL-68607]; Department of Medicine
FX The authors thank Pat Harris at the Equine Studies Group, Waltham Centre
   for Pet Nutrition, and UK Equine for providing the blood samples for the
   horse on pasture grass shown in Figure 4. The present work was supported
   by NIH grants HL-68607 and startup funds from the Department of Medicine
   to R.J.J.
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NR 72
TC 44
Z9 48
U1 2
U2 75
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0737-0806
EI 1542-7412
J9 J EQUINE VET SCI
JI J. Equine Vet. Sci.
PD FEB
PY 2013
VL 33
IS 2
BP 120
EP 126
DI 10.1016/j.jevs.2012.05.004
PG 7
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA 087VK
UT WOS:000314792000009
PM 23439477
OA Green Accepted
DA 2025-06-11
ER

PT J
AU De Nigris, F
   Balestrieri, ML
   Williams-Ignarro, S
   D'Armiento, FP
   Fiorito, C
   Ignarro, LJ
   Napoli, C
AF de Nigris, Filomena
   Balestrieri, Maria Luisa
   Williams-Ignarro, Sharon
   D'Armiento, Francesco P.
   Fiorito, Carmela
   Ignarro, Louis J.
   Napoli, Claudio
TI The influence of pomegranate fruit extract in comparison to regular
   pomegranate juice and seed oil on nitric oxide and arterial function in
   obese Zucker rats
SO NITRIC OXIDE-BIOLOGY AND CHEMISTRY
LA English
DT Article
DE pomegranate; arterial function; nitric oxide; metabolic syndrome
ID SUPPLEMENTATION; ANTIOXIDANT; EXPRESSION; OXIDATION; DISEASES
AB Metabolic syndrome includes most widely distributed clinical conditions such as obesity, hypertension, dislipidemia, and diabetes. Pomegranate fruit extract (PFE), rich in polyphenolic antioxidants, reduces the expression of oxidation-sensitive genes at the sites of perturbed shear-stress. The aim of this study was to evaluate the effect of PFE in comparison to regular pomegranate juice (PJ) and seed oil on the biological actions of nitric oxide (NO) and the arterial function in obese Zucker rats, a model of metabolic syndrome. Our results indicated that supplementation with PFE or PJ significantly decreased the expression of vascular inflammation markers, thrombospondin (TSP), and cytokine TGF beta 1 (P < 0. 05), whereas seed oil supplementation had a significant effect only on TSP-1 expression (P < 0.05). Plasma nitrate and nitrite (NOx) levels were significantly increased by PFE and PJ (P < 0.05). Furthermore, the effect of PFE in increasing endothelial NO synthase (eNOS) expression was comparable to that of PJ. These data highlight possible clinical applications of PFE in metabolic syndrome. (c) 2007 Elsevier Inc. All rights reserved.
C1 Univ Naples 2, Sch Med 1, Dept Gen Pathol, I-80138 Naples, Italy.
   Univ Naples 2, Sch Med 1, Excellence Res Ctr Cardiovasc Dis, I-80138 Naples, Italy.
   Univ Naples 2, Sch Med 1, Dept Chem Biol & Phys, I-80138 Naples, Italy.
   Univ Naples Federico II, Dept Human Pathol, I-80131 Naples, Italy.
   Univ Calif Los Angeles, David Geffen Sch Med, Div Anesthesiol, Los Angeles, CA 90095 USA.
   Univ Calif Los Angeles, David Geffen Sch Med, Dept Mol & Med Pharmacol, Los Angeles, CA 90095 USA.
C3 Universita della Campania Vanvitelli; Universita della Campania
   Vanvitelli; Universita della Campania Vanvitelli; University of Naples
   Federico II; University of California System; University of California
   Los Angeles; University of California Los Angeles Medical Center; David
   Geffen School of Medicine at UCLA; University of California System;
   University of California Los Angeles; University of California Los
   Angeles Medical Center; David Geffen School of Medicine at UCLA
RP Napoli, C (corresponding author), Univ Naples 2, Sch Med 1, Dept Gen Pathol, Complesso S Andrea delle Dame Via de Crecchio 7, I-80138 Naples, Italy.
EM claunap@tin.it
OI Napoli, Claudio/0000-0002-5455-555X; de nigris,
   filomena/0000-0002-2322-1557; Balestrieri, Maria
   Luisa/0000-0001-6001-1789; D'ARMIENTO, Francesco
   Paolo/0000-0002-1391-6451
CR Aviram M, 2002, DRUG EXP CLIN RES, V28, P49
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NR 19
TC 103
Z9 120
U1 1
U2 16
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 1089-8603
EI 1089-8611
J9 NITRIC OXIDE-BIOL CH
JI Nitric Oxide-Biol. Chem.
PD AUG
PY 2007
VL 17
IS 1
BP 50
EP 54
DI 10.1016/j.niox.2007.04.005
PG 5
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA 195IF
UT WOS:000248405000007
PM 17553710
DA 2025-06-11
ER

PT J
AU Leite, MLC
   Nicolosi, A
AF Leite, Maria Lea Correa
   Nicolosi, Alfredo
TI Dietary patterns and metabolic syndrome factors in a non-diabetic
   Italian population
SO PUBLIC HEALTH NUTRITION
LA English
DT Article
DE Metabolic syndrome; Dietary patterns; Obesity; Dyslipidaemia; Cluster
   analysis
ID MONOUNSATURATED FATTY-ACIDS; CORONARY-HEART-DISEASE; NUTRITION
   EXAMINATION SURVEY; HIGH-CARBOHYDRATE DIETS; 3RD NATIONAL-HEALTH;
   GLUCOSE-METABOLISM; DIABETES-MELLITUS; OXIDATIVE STRESS;
   CARDIOVASCULAR-DISEASE; INSULIN SENSITIVITY
AB Objective: To examine the relationship between dietary patterns and metabolic syndrome.
   Design: population-based cross-sectional study. The K-means Clustering method was used to identify dietary patterns and logistic regression models were used to compare the adjusted prevalence rates of metabolic syndrome factors, stratifying by obesity status.
   Setting: The 1992-3 Italian Bollate Eye Study, a population-based survey carried out in the town of Bollate (Milan), Italy.
   Subjects: A total of 1052 non-diabetic Italian subjects, 527 men and 525 women, aged 42-74 years.
   Results: Five dietary clusters were identified: common, animal products, starch, vegetal/fat and vita in in/fibre. After adjusting for potential confounders, the starch group showed the highest prevalence of metabolic syndrome (36%) followed by the animal products group (30%); the vitamin/fibre (20%) and vegetal/fat groups (19%) showed the lowest prevalence. The starch group had more dyslipidaemia (higher TAG and lower HDL cholesterol levels) and the animal products group had a higher prevalence of impaired fasting glucose. The vitamin/fibre group had the lowest prevalence of abdominal obesity. The beneficial effect of the vegetal/fat and vitamin/fibre dietary patterns seemed stronger among the obese.
   Conclusions: Our results confirm the deleterious effect of a very-low-fat, high-carbohydrate diet and also of high intakes of animal products. The consumption of a diet high in vegetal fats or rich in fruits and vegetables is associated with a healthier metabolic profile. Reducing obesity is essential to prevent metabolic syndrome, but even among the obese dietary habits are important for preserving healthy lipid and glycaemic profiles.
C1 [Leite, Maria Lea Correa; Nicolosi, Alfredo] Natl Res Council CNR, Dept Epidemiol & Med Informat, Inst Biomed Technol, I-20090 Milan, Italy.
   [Nicolosi, Alfredo] Columbia Univ, Gertrude H Sergievsky Ctr, Sch Publ Hlth, New York, NY 10027 USA.
C3 Consiglio Nazionale delle Ricerche (CNR); Istituto di Tecnologie
   Biomediche (ITB-CNR); Columbia University
RP Leite, MLC (corresponding author), Natl Res Council CNR, Dept Epidemiol & Med Informat, Inst Biomed Technol, Via Fratelli Cervi 93, I-20090 Milan, Italy.
EM lea.correa@itb.cnr.it
RI Leite, Maria/F-5498-2013
FU National Research Council (Italy)
FX The work was supported by research programme grant funding from the
   National Research Council (Italy) in the ambit of the Project Prevention
   and Control of Disease Factors (FATMA).
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NR 58
TC 23
Z9 26
U1 0
U2 4
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 1368-9800
EI 1475-2727
J9 PUBLIC HEALTH NUTR
JI Public Health Nutr.
PD SEP
PY 2009
VL 12
IS 9
BP 1494
EP 1503
DI 10.1017/S1368980008004539
PG 10
WC Public, Environmental & Occupational Health; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health; Nutrition & Dietetics
GA 488HL
UT WOS:000269339900024
PM 19144241
OA Bronze, Green Submitted
DA 2025-06-11
ER

PT J
AU Zang, LQ
   Baharlooeian, M
   Terasawa, M
   Shimada, Y
   Nishimura, N
AF Zang, Liqing
   Baharlooeian, Maedeh
   Terasawa, Masahiro
   Shimada, Yasuhito
   Nishimura, Norihiro
TI Beneficial effects of seaweed-derived components on metabolic syndrome
   via gut microbiota modulation
SO FRONTIERS IN NUTRITION
LA English
DT Review
DE seaweed; gut microbiota; short-chain fatty acids; obesity; diabetes;
   metabolic syndrome
ID DIET-INDUCED OBESITY; OLIGOSACCHARIDES ATTENUATE HYPERTENSION; INDUCED
   PULMONARY-HYPERTENSION; STRUCTURAL-CHARACTERIZATION; SULFATED
   POLYSACCHARIDES; BIOACTIVE PEPTIDES; LIPID-METABOLISM; RHAMNAN SULFATE;
   MARINE-ALGAE; HUMAN HEALTH
AB Metabolic syndrome comprises a group of conditions that collectively increase the risk of abdominal obesity, diabetes, atherosclerosis, cardiovascular diseases, and cancer. Gut microbiota is involved in the pathogenesis of metabolic syndrome, and microbial diversity and function are strongly affected by diet. In recent years, epidemiological evidence has shown that the dietary intake of seaweed can prevent metabolic syndrome via gut microbiota modulation. In this review, we summarize the current in vivo studies that have reported the prevention and treatment of metabolic syndrome via seaweed-derived components by regulating the gut microbiota and the production of short-chain fatty acids. Among the surveyed related articles, animal studies revealed that these bioactive components mainly modulate the gut microbiota by reversing the Firmicutes/Bacteroidetes ratio, increasing the relative abundance of beneficial bacteria, such as Bacteroides, Akkermansia, Lactobacillus, or decreasing the abundance of harmful bacteria, such as Lachnospiraceae, Desulfovibrio, Lachnoclostridium. The regulated microbiota is thought to affect host health by improving gut barrier functions, reducing LPS-induced inflammation or oxidative stress, and increasing bile acid production. Furthermore, these compounds increase the production of short-chain fatty acids and influence glucose and lipid metabolism. Thus, the interaction between the gut microbiota and seaweed-derived bioactive components plays a critical regulatory role in human health, and these compounds have the potential to be used for drug development. However, further animal studies and human clinical trials are required to confirm the functional roles and mechanisms of these components in balancing the gut microbiota and managing host health.
C1 [Zang, Liqing; Nishimura, Norihiro] Mie Univ, Grad Sch Reg Innovat Studies, Tsuq, Mie, Japan.
   [Zang, Liqing; Shimada, Yasuhito; Nishimura, Norihiro] Mie Univ, Zebrafish Res Ctr, Tsu, Mie, Japan.
   [Baharlooeian, Maedeh] Khorramshahr Univ Marine Sci & Technol, Fac Marine Sci & Oceanog, Dept Marine Biol, Khorramshahr, Iran.
   [Terasawa, Masahiro] Konan Chem Mfg Co Ltd, Yokaichi, Mie, Japan.
   [Shimada, Yasuhito] Mie Univ, Dept Integrat Pharmacol, Grad Sch Med, Tsu, Mie, Japan.
   [Shimada, Yasuhito] Mie Univ, Dept Bioinformat, Adv Sci Res Promot Ctr, Tsu, Mie, Japan.
C3 Mie University; Mie University; Khorramshahr University of Marine
   Science & Technology; Mie University; Mie University
RP Zang, LQ (corresponding author), Mie Univ, Grad Sch Reg Innovat Studies, Tsuq, Mie, Japan.; Zang, LQ (corresponding author), Mie Univ, Zebrafish Res Ctr, Tsu, Mie, Japan.
EM liqing@med.mie-u.ac.jp
RI Baharlooiean, Maedeh/AAN-2434-2021; Shimada, Yasuhito/H-2916-2019; Zang,
   Liqing/AEM-5969-2022
OI Baharlooeian, Maedeh/0000-0001-9085-4015; Zang,
   Liqing/0000-0001-6936-795X; Shimada, Yasuhito/0000-0002-4111-8262
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NR 177
TC 15
Z9 16
U1 4
U2 33
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD JUN 15
PY 2023
VL 10
AR 1173225
DI 10.3389/fnut.2023.1173225
PG 18
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA K4YH9
UT WOS:001016507400001
PM 37396125
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Cho, SJ
   Lee, HJ
   Rhee, SJ
   Kim, EY
   Kim, KN
   Yoon, DH
   Ahn, YM
AF Cho, Sung Joon
   Lee, Hyun Jeong
   Rhee, Sang Jin
   Kim, Eun Young
   Kim, Kyoung-Nam
   Yoon, Dae Hyun
   Ahn, Yong Mm
TI The relationship between visceral adiposity and depressive symptoms in
   the general Korean population
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Depression; Intra-abdominal fat; Intra-peritoneal fat; Ratio; Body mass
   index; Obesity; Woman
ID BODY-MASS INDEX; QUALITY-OF-LIFE; METABOLIC SYNDROME; MAJOR DEPRESSION;
   WAIST CIRCUMFERENCE; INSULIN-RESISTANCE; GENDER-DIFFERENCES;
   NATIONAL-HEALTH; YOUNG-ADULTS; ASSOCIATION
AB Background: In Korea, depressive symptoms or depression are prevalent. Metabolic syndrome is the representative medical condition associated with depression. This study examined the association between clinically significant depressive symptoms and intra-abdominal fat, measured using abdominal computed tomography, in a large sample of the Korean population who underwent routine health examination.
   Methods: People who underwent routine health examinations at the Seoul National University Hospital Healthcare System, Gangnam Center, from October 2004 to July 2012 were included in the study. There were 11,434 cases of individuals with CT scan data and entries in the Beck Depression Inventory (BDI). Of these, 1156 men and women underwent CT scans more than once. In these cases, we analyzed the first scan.
   Results: We analyzed 4945 male and 2293 female participants; 333 participants (171 male, 162 female) were in the clinically depressed group. After controlling for confounding factors, we found that clinically depressive symptoms were associated with visceral adiposity in women. Per 1 cm(2) of visceral adipose tissue area, the risk of being clinically depressed increased 1.006-fold. Similarly, per 1% increase in the ratio of visceral and total adipose tissue area in women, the risk increased 1.028-fold.
   Conclusions: Our large-sample study showed depressive symptoms are associated with intra-abdominal fat and the ratio of visceral and total adipose area in women, after controlling for confounding factors including BMI, hypertension, and diabetes.
C1 [Cho, Sung Joon; Rhee, Sang Jin; Ahn, Yong Mm] Seoul Natl Univ Hosp, Dept Psychiat, Seoul, South Korea.
   [Ahn, Yong Mm] Seoul Natl Univ, Coll Med, Inst Human Behav Med, Seoul, South Korea.
   [Lee, Hyun Jeong] Natl Canc Control Inst, Canc Survivorship Branch, Goyang, South Korea.
   [Kim, Eun Young] Seoul Natl Univ, Coll Med, Dept Psychiat & Behav Sci, Seoul, South Korea.
   [Kim, Eun Young] Seoul Natl Univ, Mental Hlth Ctr, Hlth Care Ctr, Seoul, South Korea.
   [Kim, Kyoung-Nam] Seoul Natl Univ Hosp, Div Publ Hlth & Prevent Med, Seoul, South Korea.
   [Kim, Kyoung-Nam] Seoul Natl Univ, Coll Med, Dept Prevent Med, Seoul, South Korea.
   [Yoon, Dae Hyun] Seoul Natl Univ Hosp, Healthcare Syst Gangnam Ctr, Dept Psychiat, Seoul, South Korea.
C3 Seoul National University (SNU); Seoul National University Hospital;
   Seoul National University (SNU); Seoul National University (SNU); Seoul
   National University (SNU); Seoul National University (SNU); Seoul
   National University Hospital; Seoul National University (SNU); Seoul
   National University (SNU); Seoul National University Hospital
RP Ahn, YM (corresponding author), Seoul Natl Univ Hosp, Dept Psychiat, Seoul, South Korea.; Yoon, DH (corresponding author), Seoul Natl Univ Hosp, Healthcare Syst Gangnam Ctr, Dept Psychiat, Seoul, South Korea.
EM dhyoon@snuh.org; aym@snu.ac.kr
RI Yoon, Dae/C-4302-2013
FU Korea Healthcare Technology R&D Project, Ministry of Health and Welfare,
   Republic of Korea [A121987]
FX This work was supported by grant A121987 from the Korea Healthcare
   Technology R&D Project, Ministry of Health and Welfare, Republic of
   Korea.
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NR 70
TC 19
Z9 20
U1 0
U2 61
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD FEB 1
PY 2019
VL 244
BP 54
EP 59
DI 10.1016/j.jad.2018.09.046
PG 6
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA GZ2QZ
UT WOS:000449234400009
PM 30316052
DA 2025-06-11
ER

PT J
AU Guseman, EH
   Pfeiffer, KA
   Carlson, JJ
   Stansbury, K
   Eisenmann, JC
AF Guseman, Emily Hill
   Pfeiffer, Karin A.
   Carlson, Joseph J.
   Stansbury, Kathy
   Eisenmann, Joey C.
TI Physical activity does not attenuate the relationship between daily
   cortisol and metabolic syndrome in obese youth
SO JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
LA English
DT Article
DE adolescent; cortisol; metabolic syndrome; obesity; physical activity
ID SALIVARY CORTISOL; SYNDROME SCORE; EUROPEAN ADOLESCENTS; MORNING
   CORTISOL; RISK-FACTORS; CHILDREN; FITNESS; ASSOCIATION; STRESS;
   ADIPOSITY
AB Objective: We examined the associations among daily cortisol, physical activity (MVPA) and continuous metabolic syndrome score (cMetS) in obese youth.
   Methods: Fifty adolescents (mean age 14.8 +/- 1.9 years) were recruited from medical clinics. Daily MVPA (min/day) was assessed by accelerometry. Saliva was sampled at prescribed times: immediately upon waking; 30 min after waking; and 3, 6 and 9 h after waking. Fasting lipids, glucose, waist circumference and blood pressure were used to calculate a continuous metabolic syndrome score (cMetS). Multiple linear regression analysis was used to examine associations among variables.
   Results: The mean cMetS score was 4.16 +/- 4.30 and did not differ by clinic or sex. No significant relationship was found between cortisol area under the curve (cAUC) and cMetS, nor did the interaction of MVPA with cAUC significantly predict cMetS.
   Conclusions: Physical activity, cortisol, and metabolic risk were not associated in this sample of obese adolescents. Future research should examine the role of insulin sensitivity in these relationships.
C1 [Guseman, Emily Hill] Coll Hlth Sci, Phys Act & Hlth, Div Kinesiol & Hlth, Laramie, WY 82071 USA.
   [Guseman, Emily Hill] Univ Wyoming, Laramie, WY 82071 USA.
   [Pfeiffer, Karin A.; Carlson, Joseph J.; Stansbury, Kathy; Eisenmann, Joey C.] Michigan State Univ, E Lansing, MI 48824 USA.
C3 University of Wyoming; Michigan State University
RP Guseman, EH (corresponding author), Coll Hlth Sci, Phys Act & Hlth, Div Kinesiol & Hlth, Dept 3196,1000 E Univ Ave, Laramie, WY 82071 USA.
EM eguseman@uwyo.edu
RI Pfeiffer, Karin/D-5252-2018; Guseman, Emily/JEF-2467-2023
FU North American Society for Pediatric Exercise Medicine (NASPEM) student
   grant; Michigan State University College of Education
FX This project was funded by a North American Society for Pediatric
   Exercise Medicine (NASPEM) student grant and the Michigan State
   University College of Education. The authors wish to acknowledge the
   contributions of Dr. Jennifer Fenton, Eric Gurzell, Jason Wiesinger and
   Elizabeth Hunt, as well as the staff of the Healthy Weight Center and
   Academic General Pediatrics Clinic at Helen DeVos Children's Hospital
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NR 47
TC 4
Z9 4
U1 0
U2 7
PU WALTER DE GRUYTER GMBH
PI BERLIN
PA GENTHINER STRASSE 13, D-10785 BERLIN, GERMANY
SN 0334-018X
EI 2191-0251
J9 J PEDIATR ENDOCR MET
JI J. Pediatr. Endocrinol. Metab.
PD JAN
PY 2016
VL 29
IS 1
BP 63
EP 70
DI 10.1515/jpem-2015-0185
PG 8
WC Endocrinology & Metabolism; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Pediatrics
GA DA9QS
UT WOS:000368145200010
PM 26353167
DA 2025-06-11
ER

PT J
AU Vilar, EG
   Rojo, SS
   Oliva, SL
   Martinez, S
   Lora, AT
   Martin, IS
AF Vilar, Elena Garicano
   Rojo, Sara Sanz
   Oliva, Sara Lopez
   Martinez, Silvia
   Lora, Ana Terren
   Martin, Ismael San Mauro
TI Effect of MetioNac® in patients with metabolic syndrome who are at risk
   of metabolic dysfunction associated fatty liver disease: a randomized
   controlled trial
SO NUTRICION HOSPITALARIA
LA English
DT Article
DE Metabolic syndrome; Metabolic associated fatty liver disease;
   S-adenosyl-L-methionine; N-acetylcysteine; Thioctic acid; Vitamin B6
ID SCREENING TOOLS; OLDER-ADULTS; SHORT-FORM; CLINICAL-OUTCOMES;
   MALNUTRITION; IDENTIFICATION; VALIDATION; COMMUNITY; DISCHARGE;
   NUTRITION
AB Introduction: metabolic syndrome comprises a combination of diabetes, high blood pressure, and obesity, and metabolic associated fatty liver disease (MAFLD) is associated with it.Objective: to evaluate the effect of supplementation with S-adenosyl-L-methionine + N-acetylcysteine + thioctic acid + vitamin B6 (MetioNac (R)) for 3 months on lipidic and biochemical parameters in subjects with metabolic syndrome and at risk of MAFLD. The reduction in body weight and the oxidative stress markers malondialdehyde (MDA) and superoxide dismutase (SOD) were also evaluated.Methods: patients with metabolic syndrome, at risk of MAFLD (FIB-4 < 1.30), and with an indication for weight reduction were recruited (n = 15). Control group followed a semipersonalized Mediterranean diet (MD) for weight reduction, according to the recommendations of the Spanish Society for the Study of Obesity (SEEDO). Experimental group, in addition to the MD, took three capsules of MetioNac (R) supplement per day.Results: compared with the control group, subjects taking MetioNac (R) showed significant (p < 0.05) reductions in the levels of TG and VLDL-c, as well as in total cholesterol, LDL-c, and glucose levels. They also showed increased levels of HDL-c. Levels of AST and ALT decreased after the intervention with MetioNac (R), but this decrease did not reach statistical significance. Weight loss was observed in both groups.Conclusion: supplementation with MetioNac (R) may be protective against hyperlipidemia, insulin resistance, and overweight among metabolic syndrome patients. Further studies on this issue are needed in a larger population.
C1 [Vilar, Elena Garicano; Rojo, Sara Sanz; Oliva, Sara Lopez; Lora, Ana Terren; Martin, Ismael San Mauro] Res Ctr Nutr & Hlth, CINUSA Grp, Paseo Habana 43, Madrid 28036, Spain.
   [Martinez, Silvia] Margan Biotech, Ajalvir, Madrid, Spain.
RP Martin, IS (corresponding author), Res Ctr Nutr & Hlth, CINUSA Grp, Paseo Habana 43, Madrid 28036, Spain.
EM info@grupocinusa.es
RI González-Martínez, Silvia/ABA-6150-2021
CR Administracao Central do Sistema de Sat:de (ACSS). Relatorio de monitorizacao da Rede Nacional de Cuidados Continuados Integrados (RNCCI), 2015, Servico Nacional de Sat:de: Administracao Central do Sistema de Sat:de (ACSS), P9
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   Young AM, 2013, NUTRITION, V29, P101, DOI 10.1016/j.nut.2012.04.007
NR 30
TC 1
Z9 1
U1 0
U2 0
PU ARAN EDICIONES, S L
PI MADRID
PA C/ CASTELLO, 128, 1O, MADRID, 28006, SPAIN
SN 0212-1611
EI 1699-5198
J9 NUTR HOSP
JI Nutr. Hosp.
PD JUL-AUG
PY 2023
VL 40
IS 4
BP 755
EP 762
DI 10.20960/nh.04635
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA X6SO7
UT WOS:001099729300011
PM 37409712
DA 2025-06-11
ER

PT J
AU Azadbakht, L
   Kelishadi, R
   Saraf-Bank, S
   Qorbani, M
   Ardalan, G
   Heshmat, R
   Taslimi, M
   Motlagh, ME
AF Azadbakht, Leila
   Kelishadi, Roya
   Saraf-Bank, Sahar
   Qorbani, Mostafa
   Ardalan, Gelayol
   Heshmat, Ramin
   Taslimi, Mahnaz
   Motlagh, Mohammad Esmaeil
TI The association of birth weight with cardiovascular risk factors and
   mental problems among Iranian school-aged children: The CASPIAN-III
   Study
SO NUTRITION
LA English
DT Article
DE Birth weight; Cardiovascular risk; Mental health
ID SYSTOLIC BLOOD-PRESSURE; BODY-MASS INDEX; METABOLIC SYNDROME; CENTRAL
   ADIPOSITY; MATER-UNIVERSITY; NATIONAL SAMPLE; YOUNG ADULTHOOD; DISEASE
   RISK; ADOLESCENTS; DEPRESSION
AB Objective: Both high and low birth weights (HBW and LBW) are risk factors for adulthood diseases. The aim of this study was to investigate the association of birth weight with cardiovascular disease (CVD) risk factors and mental problems among Iranian school-aged children.
   Methods: This national multicenter study of school-aged children entitled CASPIAN III was conducted among 5528 students in ranging from ages 10 to 18 y. Biochemical indices and anthropometric measurements were collected. Mental health was assessed by questionnaire. To investigate the association between birth weight categories and CVD risk factors and mental problems, multivariate logistic regression was used.
   Results: HBW adolescents were at higher risk for elevated diastolic blood pressure (DBP) (P-trend < 0.05), low levels of high-density lipoprotein cholesterol (HDL-C) (Ptrend < 0.05), and lower risk for general obesity (Ptrend < 0.05) compared with the LBW category. HBW had no significant association with mental problems (P-trend > 0.05) compared with LBW adolescents. The results of regression analysis, which considered normal birth weight as the reference group, showed that LBW students had lower risk for overweight and obesity (P < 0.01), as well as higher DBP (P < 0.05) but they were at higher risk for lower levels of HDL-C (P < 0.01). Furthermore, birth-weight categories had a U-shaped relationship with mental problems and sleep disorders (P < 0.05). Risk for confusion was higher among the LBW group (P < 0.05).
   Conclusion: Findings from this population-based study revealed a positive relation between birth weight categories and CVD risk factors. Compared with students born with normal weight, those born with HBW and LBW were at higher risk for mental problems, sleep disorders, and confusion. (C) 2014 Elsevier Inc. All rights reserved.
C1 [Azadbakht, Leila; Saraf-Bank, Sahar] Isfahan Univ Med Sci, Food Secur Res Ctr, Sch Nutr & Food Sci, Dept Community Nutr, Esfahan, Iran.
   [Kelishadi, Roya] Isfahan Univ Med Sci, Fac Med, Dept Pediat, Esfahan, Iran.
   [Kelishadi, Roya] Isfahan Univ Med Sci, Child Growth & Dev Res Ctr, Esfahan, Iran.
   [Qorbani, Mostafa] Alborz Univ Med Sci, Dept Publ Hlth, Karaj, Iran.
   [Ardalan, Gelayol] Off Sch Hlth Hlth & Med Educ, Tehran, Iran.
   [Heshmat, Ramin] Univ Tehran Med Sci, Chron Dis Res Ctr, Endocrinol & Metab Populat Sci Inst, Endocrinol & Metab Res Inst,Dept Epidemiol, Tehran, Iran.
   [Taslimi, Mahnaz] Bur Hlth & Fitness, Tehran, Iran.
   [Motlagh, Mohammad Esmaeil] Ahvaz Jundishapur Univ Med Sci, Dept Pediat, Ahvaz, Iran.
C3 Isfahan University of Medical Sciences; Isfahan University of Medical
   Sciences; Isfahan University of Medical Sciences; Alborz University of
   Medical Sciences; Tehran University of Medical Sciences; Ahvaz
   Jundishapur University of Medical Sciences (AJUMS)
RP Kelishadi, R (corresponding author), Isfahan Univ Med Sci, Fac Med, Dept Pediat, Esfahan, Iran.
EM kelishadi@med.mui.ac.ir
RI Saraf-Bank, Sahar/W-6232-2019; Qorbani, Mostafa/M-8171-2017; Heshmat,
   Ramin/S-7435-2017; motlagh, Mohammad/AAC-2653-2019; Kelishadi,
   Roya/E-6154-2012; Azadbakht, Leila/N-2801-2018
OI Kelishadi, Roya/0000-0001-7455-1495; motlagh, mohammad
   esmaiel/0000-0002-2971-8660; Qorbani, Mostafa/0000-0001-9465-7588;
   Azadbakht, Leila/0000-0002-5955-6818
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NR 62
TC 18
Z9 20
U1 0
U2 9
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0899-9007
EI 1873-1244
J9 NUTRITION
JI Nutrition
PD FEB
PY 2014
VL 30
IS 2
BP 150
EP 158
DI 10.1016/j.nut.2013.06.005
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 293BZ
UT WOS:000329947700005
PM 24206820
DA 2025-06-11
ER

PT J
AU Lee, SB
   Kim, HG
   Lee, JS
   Kim, WY
   Lee, MM
   Kim, YH
   Lee, JO
   Kim, HS
   Son, CG
AF Lee, Sung Bae
   Kim, Hyeong Geug
   Lee, Jin Seok
   Kim, Won Yong
   Lee, Myong Min
   Kim, Yun Hee
   Lee, Jung Ok
   Kim, Hyeon Soo
   Son, Chang Gue
TI Intermittent restraint-induced sympathetic activation attenuates hepatic
   steatosis and inflammation in a high-fat diet-fed mouse model
SO AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
LA English
DT Article
DE beneficial effects; NAFLD; NASH; stress; sympathetic activation
ID BROWN ADIPOSE-TISSUE; LIVER-DISEASE; OXIDATIVE STRESS; METABOLIC
   SYNDROME; LIPID-METABOLISM; FOOD-INTAKE; INJURY; ACID; PATHOPHYSIOLOGY;
   EPINEPHRINE
AB Nonalcoholic fatty liver disease (NAFLD) is very prevalent worldwide and is associated with insulin resistance and metabolic syndrome. Stress is a physiological and biological response to maintain homeostasis of the body against stressors while severe stress response is an important contributor to various illnesses, including metabolic syndrome and brain disorders. We have evaluated the effects of intermittent restraint stress on NAFLD in a high-fat diet (HFD)-fed mouse model. C57/BL6 mice had free access to a 60% HFD for 8 wk, with or without intermittent restraint stress (3 h) conducted three times a week. HFD administration increased fat accumulation in liver tissues. Unlike the stressed standard diet group, the levels of hepatic total cholesterol and triglycerides were significantly ameliorated in the HFD with stress group compared with the HFD alone group. These beneficial results were in accordance with serum levels of liver enzymes (aspartate transaminase, alanine transaminase) and hepatic levels of TNF-alpha and oxidative stress parameters (reactive oxygen species, nitric oxide, and malondialdehyde). The intermittent restraint stress significantly attenuated the HFD-derived alterations in serum insulin levels, hepatic protein kinase B activity, and gene expression, especially related to lipogenesis. This intermittent restraint stress also elevated the serum epinephrine concentration and activated the adrenergic receptor beta 2 or beta 3 in livers or white adipose tissue (WAT). Activation of energy expenditure markers (uncoupling protein 1, peroxisome proliferator-activated receptor-gamma coactivator-1 alpha) in brown adipose tissue and the browning of WAT were also observed in the HFD with stress group. Taken together, our findings showed the beneficial effects of sympathetic activation by intermittent restraint stress on HFD-induced hepatic steatosis and partial inflammation.
   NEW & NOTEWORTHY In modern society, stress is a part of daily life, and a certain level of stress is inevitable to most of the general population. Uncontrolled severe stress is obviously harmful; however, certain kind/level of stress could be beneficial on lipid metabolism via sympathetic activation. Our data suggest that a sympathetic activation by intermittent restraint stress could play a positive role in maintaining the balance of hepatic lipid metabolism, especially under high-fat diet conditions.
C1 [Lee, Sung Bae; Kim, Hyeong Geug; Lee, Jin Seok; Kim, Won Yong; Lee, Myong Min; Son, Chang Gue] Daejeon Univ, Inst Tradit Med & Biosci, 176 Split 75 Daedeokdae Ro, Daejeon 35235, South Korea.
   [Kim, Yun Hee] Korea Inst Oriental Med, Daejeon, South Korea.
   [Lee, Jung Ok; Kim, Hyeon Soo] Korea Univ, Dept Anat, Coll Med, Seoul, South Korea.
C3 Daejeon University; Korea Institute of Oriental Medicine (KIOM); Korea
   University; Korea University Medicine (KU Medicine)
RP Son, CG (corresponding author), Daejeon Univ, Inst Tradit Med & Biosci, 176 Split 75 Daedeokdae Ro, Daejeon 35235, South Korea.
EM ckson@dju.ac.kr
RI LEE, HYUN/ABC-6119-2021; Kim, Won/T-3947-2019; son, chang
   gue/ABC-2215-2021
OI Son, Chang-Gue/0000-0003-4876-0167; Kim, Yun Hee/0000-0002-3138-3417
FU Korea Institute of Oriental Medicine [K16842]; National Research
   Foundation of Korea [2018R1A6A1A03025221]
FX This research was supported by grants from the Korea Institute of
   Oriental Medicine (K16842) and the National Research Foundation of Korea
   (2018R1A6A1A03025221).
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NR 60
TC 8
Z9 8
U1 0
U2 16
PU AMER PHYSIOLOGICAL SOC
PI Rockville
PA 6120 Executive Blvd, Suite 600, Rockville, MD, UNITED STATES
SN 0193-1857
EI 1522-1547
J9 AM J PHYSIOL-GASTR L
JI Am. J. Physiol.-Gastroint. Liver Physiol.
PD DEC
PY 2019
VL 317
IS 6
BP G811
EP G823
DI 10.1152/ajpgi.00047.2019
PG 13
WC Gastroenterology & Hepatology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Gastroenterology & Hepatology; Physiology
GA JQ1BP
UT WOS:000498689000007
PM 31604029
OA Bronze
DA 2025-06-11
ER

PT J
AU Ward, AMV
   Syddall, HE
   Wood, PJ
   Dennison, EM
   Phillips, DIW
AF Ward, AMV
   Syddall, HE
   Wood, PJ
   Dennison, EM
   Phillips, DIW
TI Central hypothalamic-pituitary-adrenal activity and the metabolic
   syndrome: Studies using the corticotrophin-releasing hormone test
SO METABOLISM-CLINICAL AND EXPERIMENTAL
LA English
DT Article
ID CARDIOVASCULAR RISK-FACTORS; LOW-BIRTH-WEIGHT; PLASMA-CORTISOL
   CONCENTRATIONS; STRESS-INDUCED CORTISOL; BODY-FAT DISTRIBUTION;
   INSULIN-RESISTANCE; HUMAN OBESITY; BETA-CELL; MEN; WOMEN
AB A number of studies have suggested that the metabolic syndrome (principally, the combination of hypertension, glucose intolerance, and dyslipidemia) is associated with subtle dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis leading to raised circulating cortisol concentrations. The mechanisms underlying these observations are not known. We assessed the salivary cortisol response to awakening and pituitary-adrenal responses during a 100-mug human corticotrophin-releasing hormone (CRH) test and a dexamethasone-suppressed CRH test in a well-characterized group of 65-year-old men (n = 122). In the cohort from which this subgroup was drawn, there were associations between the components of the metabolic syndrome and 9 AM cortisol concentration in line with previous studies. However, there were no significant associations between blood pressure, glucose tolerance, and lipid concentrations and the dynamic tests of HPA activity. We therefore found no evidence to suggest that exaggerated pituitary responsiveness or increased central drive to the pituitary, as determined by CRH testing, plays a part in the development of the metabolic syndrome. (C) 2004 Elsevier Inc. All rights reserved.
C1 Univ Southampton, MRC, Environm Epidemiol Unit, Southampton Gen Hosp, Southampton SO16 6YD, Hants, England.
   Southampton Gen Hosp, Reg Endocrine Lab, Southampton SO16 6YD, Hants, England.
C3 University of Southampton; University of Southampton
RP Phillips, DIW (corresponding author), Univ Southampton, MRC, Environm Epidemiol Unit, Southampton Gen Hosp, Tremona Rd, Southampton SO16 6YD, Hants, England.
OI Dennison, Elaine/0000-0002-3048-4961; Syddall, Holly/0000-0003-0171-0306
FU NICHD NIH HHS [1 R01 HD4117-01] Funding Source: Medline
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NR 32
TC 12
Z9 14
U1 0
U2 1
PU W B SAUNDERS CO
PI PHILADELPHIA
PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA
   19106-3399 USA
SN 0026-0495
J9 METABOLISM
JI Metab.-Clin. Exp.
PD JUN
PY 2004
VL 53
IS 6
BP 720
EP 726
DI 10.1016/j.metabol.2004.01.008
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 828RF
UT WOS:000221989800006
PM 15164318
DA 2025-06-11
ER

PT J
AU Belcaro, G
   Cornelli, U
   Luzzi, R
   Cesarone, MR
   Dugall, M
   Feragalli, B
   Errichi, S
   Ippolito, E
   Grossi, MG
   Hosoi, M
   Cornelli, M
   Gizzi, G
AF Belcaro, G.
   Cornelli, U.
   Luzzi, R.
   Cesarone, M. R.
   Dugall, M.
   Feragalli, B.
   Errichi, S.
   Ippolito, E.
   Grossi, M. G.
   Hosoi, M.
   Cornelli, M.
   Gizzi, G.
TI Pycnogenol® Supplementation Improves Health Risk Factors in Subjects
   with Metabolic Syndrome
SO PHYTOTHERAPY RESEARCH
LA English
DT Article
DE metabolic syndrome; Pycnogenol (R); glycemia; triglycerides; HDL
   cholesterol; blood pressure
ID PINE BARK EXTRACT; DOUBLE-BLIND; ASSOCIATION CONFERENCE; ENDOTHELIAL
   FUNCTION; PHYSICAL-ACTIVITY; OXIDATIVE STRESS; PREVENTION
AB This open, controlled study evaluated the effects of 6month supplementation with Pycnogenol (R) maritime pine bark extract on health risk factors in subjects with metabolic syndrome. Pycnogenol (R) was used with the aim of improving risk factors associated with metabolic syndrome, central obesity, elevated triglycerides (TG), low HDL cholesterol, high blood pressure and fasting blood glucose. Sixty-four subjects (range 45-55years) presenting with all five risk factors of metabolic syndrome were included, and Pycnogenol (R) was administered for 6months. A group of 66 equivalent subjects were followed up as controls. In the 6-month study Pycnogenol (R) supplementation 150mg/day decreased waist circumference, TG levels, blood pressure and increased the HDL cholesterol levels in subjects. Pycnogenol lowered fasting glucose from baseline 123 +/- 8.6mg/dl to 106.4 +/- 5.3 after 3months and to 105.3 +/- 2.5 at the end of the study (p<0.05 vs controls). Men's waist circumference decreased with Pycnogenol from 106.2 +/- 2.2cm to 98.8 +/- 2.3cm and to 98.3 +/- 2.1 after 3 and 6months. Women's waist decreased from 90.9 +/- 1.6cm to 84.6 +/- 2.1cm and to 83.6 +/- 2.2cm after 3 and 6months. Both genders waist circumference reduction was significant as compared to controls at both time points. In addition, plasma free radicals decrease in the Pycnogenol group was more effective than in the control group (-34.6%; p<0.05). In conclusion, this study indicates a role for Pycnogenol (R) for improving health risk factors in subjects with metabolic syndrome. Copyright (c) 2013 John Wiley & Sons, Ltd.
RP Belcaro, G (corresponding author), IRVINE3 LABS, Ss 16 Bis 94, Spoltore, PE, Italy.
EM cardres@pe.abol.it
OI Feragalli, Beatrice/0000-0002-6222-024X
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NR 36
TC 25
Z9 28
U1 0
U2 15
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0951-418X
EI 1099-1573
J9 PHYTOTHER RES
JI Phytother. Res.
PD OCT
PY 2013
VL 27
IS 10
BP 1572
EP 1578
DI 10.1002/ptr.4883
PG 7
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 230TK
UT WOS:000325365700018
PM 23359520
DA 2025-06-11
ER

PT J
AU Coudray, C
   Fouret, G
   Lambert, K
   Ferreri, C
   Rieusset, J
   Blachnio-Zabielska, A
   Lecomte, J
   Elle, RE
   Badia, E
   Murphy, MP
   Feillet-Coudray, C
AF Coudray, Charles
   Fouret, Gilles
   Lambert, Karen
   Ferreri, Carla
   Rieusset, Jennifer
   Blachnio-Zabielska, Agnieszka
   Lecomte, Jerome
   Elle, Raymond Ebabe
   Badia, Eric
   Murphy, Michael P.
   Feillet-Coudray, Christine
TI A mitochondrial-targeted ubiquinone modulates muscle lipid profile and
   improves mitochondrial respiration in obesogenic diet-fed rats
SO BRITISH JOURNAL OF NUTRITION
LA English
DT Article
DE High-fat diet; Metabolic syndrome; Muscle; MitoQ; Mitochondria;
   Phospholipids; Fatty acids
ID HIGH-FAT DIET; AMELIORATES METABOLIC SYNDROME; INSULIN-RESISTANCE;
   SKELETAL-MUSCLE; SPHINGOLIPID METABOLISM; ANTIOXIDANT MITOQ; OXIDATIVE
   STRESS; PROTEIN-KINASE; LIVER-DISEASE; FED MICE
AB The prevalence of the metabolic syndrome components including abdominal obesity, dyslipidaemia and insulin resistance is increasing in both developed and developing countries. It is generally accepted that the development of these features is preceded by, or accompanied with, impaired mitochondrial function. The present study was designed to analyse the effects of a mitochondrial-targeted lipophilic ubiquinone (MitoQ) on muscle lipid profile modulation and mitochondrial function in obesogenic diet-fed rats. For this purpose, twenty-four young male Sprague-Dawley rats were divided into three groups and fed one of the following diets: (1) control, (2) high fat (HF) and (3) HF+MitoQ. After 8 weeks, mitochondrial function markers and lipid metabolism/profile modifications in skeletal muscle were measured. The HF diet was effective at inducing the major features of the metabolic syndrome - namely, obesity, hepatic enlargement and glucose intolerance. MitoQ intake prevented the increase in rat body weight, attenuated the increase in adipose tissue and liver weights and partially reversed glucose intolerance. At the muscle level, the HF diet induced moderate TAG accumulation associated with important modifications in the muscle phospholipid classes and in the fatty acid composition of total muscle lipid. These lipid modifications were accompanied with decrease in mitochondrial respiration. MitoQ intake corrected the lipid alterations and restored mitochondrial respiration. These results indicate that MitoQ protected obesogenic diet-fed rats from some features of the metabolic syndrome through its effects on muscle lipid metabolism and mitochondrial activity. These findings suggest that MitoQ is a promising candidate for future human trials in the metabolic syndrome prevention.
C1 [Coudray, Charles; Fouret, Gilles; Feillet-Coudray, Christine] INRA, UMR Muscular Dynam & Metab 866, Pl Viala, F-34060 Montpellier, France.
   [Lambert, Karen; Elle, Raymond Ebabe; Badia, Eric] Univ Montpellier, CNRS UMR9214, INSERM U1046, F-34295 Montpellier, France.
   [Ferreri, Carla] Isti Sintesi Organ Fotoreatt ISOF Bio Free Radics, I-40129 Bologna, Italy.
   [Rieusset, Jennifer] INSERM, Fac Med Lyon Sud, UMR U1060, F-69921 Oullins, France.
   [Blachnio-Zabielska, Agnieszka] Med Univ, Dept Physiol, Mickiewicza 2c, PL-15222 Bialystok, Poland.
   [Lecomte, Jerome] Ctr Rech Agron Dev CIRAD SupAgro, UMR IATE, F-34398 Montpellier, France.
   [Murphy, Michael P.] MRC, Mitochondrial Biol Unit, Hills Rd, Cambridge CB2 0XY, England.
C3 INRAE; Institut National de la Sante et de la Recherche Medicale
   (Inserm); Universite de Montpellier; Centre National de la Recherche
   Scientifique (CNRS); CNRS - National Institute for Biology (INSB);
   Consiglio Nazionale delle Ricerche (CNR); Istituto per la Sintesi
   Organica e la Fotoreattivita (ISOF-CNR); Institut National de la Sante
   et de la Recherche Medicale (Inserm); Universite Claude Bernard Lyon 1;
   Medical University of Bialystok; Universite de Montpellier; Institut
   Agro; Montpellier SupAgro; CIRAD
RP Coudray, C (corresponding author), INRA, UMR Muscular Dynam & Metab 866, Pl Viala, F-34060 Montpellier, France.
EM coudray@supagro.inra.fr
RI Lambert, Karen/MJQ-7172-2025; COUDRAY, Charles/AGG-4757-2022;
   Blachnio-Zabielsk, Agnieszka/A-4879-2018; Rieusset,
   Jennifer/F-1595-2018; FERRERI, CARLA/G-6821-2013; Murphy,
   Michael/C-2120-2009
OI Lab, Carmen/0000-0002-5935-3236; Rieusset, Jennifer/0000-0002-1587-2253;
   Blachnio-Zabielska, Agnieszka/0000-0002-8055-0576; Coudray,
   Charles/0000-0003-2680-7796; Lambert, Karen/0000-0002-6389-2451;
   FERRERI, CARLA/0000-0002-1359-0869; BADIA, Eric/0000-0002-8922-9834;
   Murphy, Michael/0000-0003-1115-9618; Carmen, Team2/0000-0001-9867-5724
FU EU [CM0603]; French Lipid Nutrition Group; National (French) Institute
   for Agronomic Research; Human Nutrition Department (Alim-H department);
   MRC [MC_U105663142] Funding Source: UKRI
FX The support from the side of the EU project CM0603 is also kindly
   acknowledged. The authors acknowledge the financial support of the
   French Lipid Nutrition Group and the National (French) Institute for
   Agronomic Research and in particular the Human Nutrition Department
   (Alim-H department).
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NR 57
TC 37
Z9 41
U1 0
U2 15
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1145
EI 1475-2662
J9 BRIT J NUTR
JI Br. J. Nutr.
PD APR 14
PY 2016
VL 115
IS 7
BP 1155
EP 1166
DI 10.1017/S0007114515005528
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA DH6BW
UT WOS:000372877000003
PM 26856891
OA Green Submitted, Bronze
DA 2025-06-11
ER

PT J
AU Manning, PJ
   Sutherland, WHF
   Williams, SM
   Walker, RJ
   Berry, EA
   De Jong, SA
   Ryalls, AR
AF Manning, P. J.
   Sutherland, W. H. F.
   Williams, S. M.
   Walker, R. J.
   Berry, E. A.
   De Jong, S. A.
   Ryalls, A. R.
TI The effect of lipoic acid and vitamin E therapies in individuals with
   the metabolic syndrome
SO NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
LA English
DT Article
DE Antioxidant; Metabolic syndrome; Non esterified fatty acids; Lipoic
   acid; Vitamin E
ID FREE FATTY-ACID; INSULIN-RESISTANCE; GLUCOSE-METABOLISM;
   ALPHA-TOCOPHEROL; PLASMA; SUPPLEMENTATION; INFLAMMATION; COMBINATION
AB The metabolic syndrome is associated with abnormal glucose and lipid metabolism, insulin resistance, increased oxidative stress and pro-inflammatory activity that increase the risk of type 2 diabetes and cardiovascular disease. The aim of this study was to investigate the effect of treatment with the antioxidant alpha-lipoic acid (ALA) with or without vitamin E supplementation, on markers of insulin resistance and systemic inflammation and plasma nonesterified fatty acid (NEFA) concentrations in individuals with the metabolic syndrome. In a randomized, double-blind, placebo-controlled trial, subjects with the metabolic syndrome received ALA (600 mg/day, n = 34), vitamin E (100 IU/day, n = 36), both ALA and vitamin E (n = 41), or matching placebo (n = 40) for 1 year. Fasting circulating concentrations of glucose and insulin were measure every 3 months and NEFA, markers of inflammation, adiponectin and vitamin E were measured at 6 monthly intervals. Plasma NEFA concentrations decreased [-10 (-18, 0)%] at a marginal level of significance (p = 0.05) in those who received ALA alone compared with placebo and decreased [-8 (-14, -1)% (95% CI)] significantly (P = 0.02) in participants who were randomised to ALA with and without vitamin E compared with those who did not receive ALA. Fasting glucose, insulin, homeostatic model assessment of insulin resistance, adiponectin, and markers of inflammation did not change significantly during the study. These data suggest that prolonged treatment with ALA may modestly reduce plasma NEFA concentrations but does not alter insulin or glucose levels in individuals with the metabolic syndrome. (C) 2011 Elsevier B.V. All rights reserved.
C1 [Manning, P. J.; Sutherland, W. H. F.; Williams, S. M.; Walker, R. J.; Berry, E. A.; De Jong, S. A.; Ryalls, A. R.] Univ Otago, Dunedin Sch Med, Dept Med, Dunedin, New Zealand.
C3 University of Otago
RP Manning, PJ (corresponding author), Dunedin Sch Med, Dept Med, POB 913, Dunedin 9054, New Zealand.
EM PatrickManning@healthotago.co.nz
RI Walker, Robert/B-1498-2010; Williams, Sheila/L-4028-2019
FU Health Research Council of New Zealand
FX The authors are grateful to the participants in the study and to Ashley
   Duncan from the Human Nutrition Department, University of Otago for
   measuring plasma vitamin E concentrations. This study was supported by a
   grant from the Health Research Council of New Zealand.
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NR 32
TC 41
Z9 43
U1 0
U2 12
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0939-4753
EI 1590-3729
J9 NUTR METAB CARDIOVAS
JI Nutr. Metab. Carbiovasc. Dis.
PD JUN
PY 2013
VL 23
IS 6
BP 543
EP 549
DI 10.1016/j.numecd.2011.11.006
PG 7
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism; Nutrition
   & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism;
   Nutrition & Dietetics
GA 167QE
UT WOS:000320646000010
PM 22402059
DA 2025-06-11
ER

PT J
AU Kagota, S
   Tada, Y
   Yamaguchi, Y
   Kubota, Y
   Nejime, N
   Nakamura, K
AF Kagota, Satomi
   Tada, Yukari
   Yamaguchi, Yu
   Kubota, Yoko
   Nejime, Namie
   Nakamura, Kazuki
TI Abnormalities of nitric oxide-mediated vasorelaxation in a rat model of
   metabolic syndrome: Involvement of peroxynitrite formation
SO CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
LA English
DT Article; Proceedings Paper
CT 2nd International Symposium on Lifestyle-Related Disease - Perspective
   for Primary Prevention and Treatment in Animal Models and Humans
CY OCT 21-22, 2006
CL Nishinomiya, JAPAN
SP Minist Educ, Culture, Sports, Sci & Technol
DE endothelium; metabolic syndrome; nitric oxide; oxidative stress;
   peroxynitrite; vasorelaxation
ID ENDOTHELIAL DYSFUNCTION; TELMISARTAN; SYNTHASE
AB 1. We reported previously that nitric oxide (NO)-mediated relaxation is impaired, despite an increase in NO production from the endothelium, in the thoracic aorta of SHR/NDmcr-cp (SHR-cp) rats, an animal model of the metabolic syndrome. In the present study, we investigated whether telmisartan, an angiotensin II receptor antagonist, can improve abnormal vasorelaxation responses.
   2. Treatment with telmisartan (10 mg/kg per day, p.o.) for 8 weeks reduced elevated blood pressure in SHR-cp rats, but did not affect the increased bodyweight, serum triglyceride and glucose levels. Telmisartan restored impaired acetylcholine-induced relaxation. Both increased endothelial NO synthase protein expression in aortas and 3-nitrotyrosine content, evidence of peroxynitrite formation, were significantly suppressed by telmisartan. Serum levels of thiobarbituric acid-reactive substances, an index of oxidized lipids, were significantly decreased.
   3. These results suggest that telmisartan can reduce the decline in NO bioavailability caused by peroxynitrite formation in the aortas of SHR-cp rats. We propose that antagonism of angiotensin II action may be effective in preventing vascular endothelial dysfunction in metabolic syndrome.
C1 Mukogawa Womens Univ, Sch Pharmaceut Sci, Dept Pharmacol, Nishinomiya, Hyogo 6638179, Japan.
C3 Mukogawa Women's University
RP Kagota, S (corresponding author), Mukogawa Womens Univ, Sch Pharmaceut Sci, Dept Pharmacol, 11-68 Koshien Kyuban Cho, Nishinomiya, Hyogo 6638179, Japan.
EM skagota@mukogawa-u.ac.jp
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NR 13
TC 0
Z9 0
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0305-1870
EI 1440-1681
J9 CLIN EXP PHARMACOL P
JI Clin. Exp. Pharmacol. Physiol.
PD NOV
PY 2007
VL 34
SU 1
BP S23
EP S25
DI 10.1111/j.1440-1681.2007.04765.x
PG 3
WC Pharmacology & Pharmacy; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Pharmacology & Pharmacy; Physiology
GA 229CZ
UT WOS:000250780400009
DA 2025-06-11
ER

PT J
AU Kim, CJ
   Kang, HS
   Schlenk, EA
   Chae, SM
AF Kim, Chun-Ja
   Kang, Hee Sun
   Schlenk, Elizabeth A.
   Chae, Sun-Mi
TI Assessment of Cardiovascular Risk in Adults With Type 2 Diabetes and
   Metabolic Syndrome Framingham Versus UKPDS Equations
SO DIABETES EDUCATOR
LA English
DT Article
ID LIFE-STYLE INTERVENTION; CORONARY-HEART-DISEASE; PRIMARY PREVENTION;
   POPULATION; MORTALITY; MELLITUS; EPIDEMIOLOGY; ENGINE; INDIVIDUALS;
   PERFORMANCE
AB Purpose The purpose of this study was to assess risk of cardiovascular disease (CVD) by comparing the Framingham and United Kingdom Prospective Diabetes Study (UKPDS) risk equations in Korean adults with type 2 diabetes (T2DM) and metabolic syndrome.
   Methods The study was a cross-sectional survey enrolling a convenience sample of 110 Korean adults with T2DM and metabolic syndrome. The 10-year CVD risk scores were calculated using the Framingham risk equation and UKPDS risk engines.
   Results Overall participants had a moderate prevalence (average, 64.3%) of metabolic syndrome factors, with the most prevalent being abdominal obesity (86.4%) and elevated blood pressure (78.2%). A lower percentage of women were current smokers and consumed alcohol than men, whereas a higher percentage of men had their weight and stress controlled than women. The mean scores of 10-year CVD risk using the Framingham and UKPDS equations were 14.55% and 15.99%, respectively. However, there were no significant differences between results of the 2 equations. Regarding level of CVD risk, the percentage of high risk (>20%) was about 24% using both equations. Also, the area under the receiver operating characteristic curves using Framingham and UKPDS equations was similar: 0.707 and 0.696, respectively, which indicated moderate accuracy.
   Conclusions About one-fourth of adults with T2DM and metabolic syndrome had high level of CVD risk (>20%). In practice, people with diabetes and metabolic syndrome could be managed earlier and more intensively based on their risk estimated by the Framingham or UKPDS equations.
C1 [Kim, Chun-Ja] Ajou Univ, Coll Nursing, Suwon 443721, South Korea.
   [Kang, Hee Sun] Chung Ang Univ, Red Cross Coll Nursing, Seoul, South Korea.
   [Schlenk, Elizabeth A.] Univ Pittsburgh, Sch Nursing, Pittsburgh, PA 15261 USA.
   [Chae, Sun-Mi] Seoul Natl Univ, Coll Nursing, Seoul 151, South Korea.
C3 Ajou University; Chung Ang University; Pennsylvania Commonwealth System
   of Higher Education (PCSHE); University of Pittsburgh; Seoul National
   University (SNU)
RP Kim, CJ (corresponding author), Ajou Univ, Coll Nursing, NB 213,164 Worldcup Ro, Suwon 443721, South Korea.
EM ckimha@ajou.ac.kr
RI Chae, Sun-Mi/D-8103-2012; Kang, Hee/AAG-9381-2019; Kim,
   Chun-Ja/HKF-2429-2023
OI Schlenk, Elizabeth/0000-0001-7361-1951; Kang, Hee
   Sun/0000-0003-3808-306X; KIM, Chun-Ja/0000-0002-7594-5418
FU Basic Science Research Program through the National Research Foundation
   of Korea (NRF) - Ministry of Education [2013R1A1A2059806]; Department of
   Nursing, Graduate School, Ajou University
FX This research was partly supported by Basic Science Research Program
   through the National Research Foundation of Korea (NRF) funded by the
   Ministry of Education (grant number: 2013R1A1A2059806) and support by a
   grant in 2008 from Department of Nursing, Graduate School, Ajou
   University.
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NR 57
TC 6
Z9 9
U1 0
U2 6
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0145-7217
EI 1554-6063
J9 DIABETES EDUCATOR
JI Diabetes Educ.
PD APR
PY 2015
VL 41
IS 2
BP 203
EP 213
DI 10.1177/0145721715572154
PG 11
WC Endocrinology & Metabolism; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Public, Environmental & Occupational Health
GA CE8EZ
UT WOS:000352075700004
PM 25699567
DA 2025-06-11
ER

PT J
AU Margari, F
   Lozupone, M
   Pisani, R
   Pastore, A
   Todarello, O
   Zagaria, G
   Minerva, F
   Palasciano, G
   Palmieri, V
AF Margari, Francesco
   Lozupone, Madia
   Pisani, Rossella
   Pastore, Adriana
   Todarello, Orlando
   Zagaria, Giuseppina
   Minerva, Francesco
   Palasciano, Giuseppe
   Palmieri, Vincenzo
TI METABOLIC SYNDROME: DIFFERENCES BETWEEN PSYCHIATRIC AND INTERNAL
   MEDICINE PATIENTS
SO INTERNATIONAL JOURNAL OF PSYCHIATRY IN MEDICINE
LA English
DT Article
DE severe mental illness; metabolic syndrome; low HDL; insulin resistance
ID 3RD NATIONAL-HEALTH; HEART-DISEASE RISK; CARDIOVASCULAR RISK;
   INSULIN-RESISTANCE; DRUG-NAIVE; SCHIZOPHRENIA; DEPRESSION;
   ANTIPSYCHOTICS; ASSOCIATION; PREVALENCE
AB Objectives: The existence of specific features of Metabolic Syndrome (MetS) in psychiatric population in comparison to not psychiatric patients has not been systematically investigated. The purpose of this study is to evaluate the differences of MetS among a group of psychiatric patients and a group of internal medicine patients in terms of anthropometric measurements, biochemical variables, and cardiovascular risk. Methods: We enrolled 83 psychiatric inpatients under pharmacological treatment (schizophrenia n = 24, bipolar disorder n = 27, major depression n = 14, other n = 18) and 77 internal medicine patients visited for supposed MetS as affected by over-weight or arterial hypertension. Results: Psychiatric patients differed from control subjects by age (yrs) (47 +/- 9 vs. 52 +/- 8.6, p = 0.001), waist circumference (cm) (111.9 +/- 10.9 vs. 106 +/- 12.6, p = 0.02), HDL cholesterol (mg/dl) (36.8 +/- 7 vs. 48 +/- 11.3, p = 0.001), serum insulin (mu U/ml) (26 +/- 12.5 vs. 16.4 +/- 8.8, p = 0.001), triglyceride/HDL cholesterol ratio (4.8 +/- 2.7 vs. 3.3 +/- 2.2, p = 0.01). Female psychiatric patients had higher levels of triglycerides (mg) (178 + 86 vs. 115 + 53, p = 0.002) and of HOMA index (7.8 + 5 vs. 3.8 + 3.3, p = 0.005). Triglycerides and triglycerides/HDL ratio levels were higher in Unipolar Depression. A positive association was found between antidepressant drug treatment with triglycerides and triglycerides/HDL ratio levels, neuroleptic treatment with the HOMA index, and antipsychotics drugs with the Framingham index. Limitations: Psychiatric study population numerosity and duration of psychiatric illness and drug treatment. Conclusions: Specific features of MetS in psychiatric population are mainly represented by young age of onset, hyperinsulinemia, increased abdominal adiposity, and low HDL cholesterol whose common denominator may be insulin-resistance.
C1 [Margari, Francesco; Lozupone, Madia; Pisani, Rossella; Pastore, Adriana; Todarello, Orlando; Zagaria, Giuseppina; Minerva, Francesco; Palasciano, Giuseppe; Palmieri, Vincenzo] Univ Aldo Moro Bari, Bari, Italy.
C3 Universita degli Studi di Bari Aldo Moro
RP Margari, F (corresponding author), Azienda Policlin, Pzza Giulio Cesare 11, I-70124 Bari, Italy.
EM francesco.margari@uniba.it
RI Margari, Francesco/K-9457-2016; Pastore, Adriana/K-2066-2018; lozupone,
   madia/F-7262-2018
OI palmieri, vincenzo ostilio/0000-0002-7649-6028; Pastore,
   Adriana/0000-0003-4254-4420; Palasciano, Giuseppe/0000-0002-0396-488X;
   lozupone, madia/0000-0002-1674-9724
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NR 73
TC 11
Z9 11
U1 0
U2 11
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0091-2174
EI 1541-3527
J9 INT J PSYCHIAT MED
JI Int. J. Psychiatr. Med.
PY 2013
VL 45
IS 3
BP 203
EP 226
DI 10.2190/PM.45.3.a
PG 24
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 207AN
UT WOS:000323568700001
PM 24066405
DA 2025-06-11
ER

PT J
AU Kamalesh, M
   Campbell, S
   Chong, CK
   Gipson, A
   Patel, N
   Ng, C
   Eckert, GJ
   Meda, M
   Sawada, S
AF Kamalesh, M.
   Campbell, S.
   Chong, C. K.
   Gipson, A.
   Patel, N.
   Ng, C.
   Eckert, G. J.
   Meda, M.
   Sawada, S.
TI Metabolic syndrome attenuates effect of chronic kidney disease on
   prevalence of coronary disease in men referred for stress imaging study
SO CLINICAL NEPHROLOGY
LA English
DT Article
DE coronary disease chronic; kidney disease; metabolic syndrome
ID RISK-FACTOR; CARDIOVASCULAR MORTALITY; PREDICTOR; OUTCOMES
AB Background: Metabolic syndrome (MS) and chronic kidney disease (CKD) are both strongly associated with coronary artery disease (CAD). Components of MS also cause CKD. The incremental effect of CKD on CAD prevalence in MS patients referred for stress imaging studies is unknown. Methods: From January to December 2005, consecutive subjects referred for a stress imaging study were prospectively enrolled. CAD was defined as fixed or reversible defects on nuclear imaging and as resting or stress-induced wall motion abnormalities on echocardiography. MS was defined using NCEP-ATP III criteria. CKD definition was based on calculated glomerular filtration rate. The independent effect of CKD on stress results was assessed using multiple variable logistic regression. Stepwise model selection was used for variable reduction, and areas under the receiver operating characteristic curves (ROC) were calculated. Results: Of 1,122 patients enrolled (mean age 61.4 years, 97% male), 535 (47%) had MS. Among MS patients, 156/535 (29%) had CKD while 116/587 (19%) subjects without MS had CKD. Subjects with CKD were older (p < 0.001) in subjects with and without MS. The presence of CKD affected prevalence of CAD in the non-MS group only, almost doubling it (20% vs. 38%, p < 0.001). Further, using the ordered nature of the 5 CKD stages, worsening severity of CKD had greater prevalence of CAD, in non-MS subjects only (p < 0.001). Conclusions: MS attenuates the effect of CKD on CAD prevalence, regardless of CKD severity. CKD almost doubles the prevalence of CAD in non-MS subjects. CKD severity is associated with greater CAD burden in the non-MS group.
C1 [Kamalesh, M.; Ng, C.; Sawada, S.] Indiana Univ, Sch Med, Div Cardiol, Indianapolis, IN 46202 USA.
   [Campbell, S.; Meda, M.] Indiana Univ, Sch Med, Dept Med, Indianapolis, IN 46202 USA.
   [Chong, C. K.; Gipson, A.; Patel, N.] Indiana Univ, Sch Med, Div Nephrol, Indianapolis, IN 46202 USA.
   [Eckert, G. J.] Indiana Univ, Sch Med, Dept Biostat, Indianapolis, IN 46202 USA.
C3 Indiana University System; Indiana University Indianapolis; Indiana
   University System; Indiana University Indianapolis; Indiana University
   System; Indiana University Indianapolis; Indiana University System;
   Indiana University Indianapolis
RP Kamalesh, M (corresponding author), Indiana Univ, Sch Med, Div Cardiol, 1481 W 10th St, Indianapolis, IN 46202 USA.
EM Masoor.kamalesh@med.va.gov
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NR 17
TC 0
Z9 0
U1 0
U2 2
PU DUSTRI-VERLAG DR KARL FEISTLE
PI DEISENHOFEN-MUENCHEN
PA BAHNHOFSTRASSE 9 POSTFACH 49, D-82032 DEISENHOFEN-MUENCHEN, GERMANY
SN 0301-0430
J9 CLIN NEPHROL
JI Clin. Nephrol.
PD MAR
PY 2009
VL 71
IS 3
BP 255
EP 262
PG 8
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 431XI
UT WOS:000265097700003
PM 19281735
DA 2025-06-11
ER

PT J
AU Alkandurur, A
   Kum, S
AF Alkandurur, Ayse
   Kum, Sadiye
TI The effect of the metabolic syndrome on the histological structure of
   the testes tissue and the sperm morphology in the rats
SO TURKISH JOURNAL OF VETERINARY & ANIMAL SCIENCES
LA English
DT Article
DE Apoptotic cells; histology; metabolic syndrome; rat; testes
ID INDUCED INSULIN-RESISTANCE; TESTICULAR DAMAGE; OXIDATIVE STRESS;
   APOPTOSIS; FRUCTOSE; SPERMATOGENESIS; EXPRESSION; CELLS
AB In this study, we aimed to investigate the effect of metabolic syndrome on spermatozoon morphology and histological, histochemical, histomorphometric changes in the testes. Twenty-four male Sprague Dawley rats (60 day-olds) were used for this purpose. The rats in the control group were fed only water and rat food, while the rats in the experimental group were fed with water containing 20% D-fructose and rats food for 16 weeks with ad libitum. At the end of the experimental period, the testes and epididymis of the rats were removed. The testes were embedded in paraffin by performing the necessary histological procedure. In the rat testes with metabolic syndrome, subbasal vacuolization, epithelial vacuolization, desquamation of germinal cells in the epithelium, the presence of germ cells across to tubular lumen for increased. Seminiferous tubule diameter was increased but the epithelial height of the tubules was decreased in the experimental group significantly. It was noted that the basement membrane surrounding the tubules and the capillary wall was thickened in rats with metabolic syndrome. In addition to these findings, apoptotic cells were increased in the experimental group compared to the the control group. It was observed that the rate of abnormal and dead spermatozoa increased. In this study, we determined the negative effects on the testes of the incidence is increasing day by day with metabolic syndrome. Due to its connection with male infertility, it is thought that more comprehensive studies will contribute to the development of scientific data.
C1 [Alkandurur, Ayse; Kum, Sadiye] Adnan Menderes Univ, Fac Vet Med, Dept Histol & Embryol, Aydin, Turkey.
C3 Adnan Menderes University
RP Kum, S (corresponding author), Adnan Menderes Univ, Fac Vet Med, Dept Histol & Embryol, Aydin, Turkey.
EM skum@adu.edu.tr
RI Kum, Sadiye/KIE-3087-2024
OI KUM, Sadiye/0000-0001-6586-4596
FU Aydin Adnan Menderes University Research Foundation [VTF-16005]
FX This research article was summarized from the first author's master
   thesis and financed by Aydin Adnan Menderes University Research
   Foundation (Project No:VTF-16005).
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NR 46
TC 2
Z9 2
U1 0
U2 3
PU Tubitak Scientific & Technological Research Council Turkey
PI ANKARA
PA ATATURK BULVARI NO 221, KAVAKLIDERE, TR-06100 ANKARA, TURKIYE
SN 1300-0128
J9 TURK J VET ANIM SCI
JI Turk. J. Vet. Anim. Sci.
PY 2021
VL 45
IS 5
BP 841
EP 850
DI 10.3906/vet-2102-45
PG 10
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA WM7PP
UT WOS:000711273500007
OA gold
DA 2025-06-11
ER

PT J
AU Sankar, MR
   Sundaram, VS
   Sankar, M
   Muthupandian, S
AF Sankar, Muthu Reka
   Sundaram, Vijayanchali Suyamprakasam
   Sankar, Muthupandi
   Muthupandian, Saravanan
TI A review of the role of herbs in managing metabolic syndrome
SO DISCOVER FOOD
LA English
DT Review
DE Metabolic syndrome; Herbs; Obesity; Dietary management; Cardiovascular
   disease
ID HEALTH-BENEFITS; LEAF; L.; GLUCOSE; EXTRACT
AB Metabolic syndrome (MetS) is characterized by five interrelated metabolic risk factors hypertension, central obesity, impaired glucose tolerance, low serum high density lipoprotein (HDL) levels and elevated serum triglycerides. Its prevalence is rising globally contributing significantly to the growing burden of cardiovascular disease (CVD) and Type 2 Diabetes Mellitus (T2DM). The complications of MetS are carried by common pathogenetic mechanisms including low grade inflammation, oxidative stress etc. While conventional approaches such as balanced diets, regular physical activity, weight management and pharmacotherapy are available, poor patient adherence and the multifactorial nature of the condition continue to drive its progression. Herbal remedies rich in phytochemicals have gained increasing attention for their potential to address various components of MetS. Many herbs including ajwain, aloe vera, basil leaf, coriander, curry leaf, fish mint, ginseng, gurmar, licorice weed, oregano, rosemary, sacred lotus, thyme and tulsi have demonstrated beneficial effects on MetS and its associated symptoms. These herbs offer therapeutic benefits in managing MetS and improving clinical outcomes. This review explores the therapeutic potential of these herbs focusing on their bioactive components and their roles in mitigating the progression of metabolic syndrome.
C1 [Sankar, Muthu Reka; Sundaram, Vijayanchali Suyamprakasam] Deemed Be Univ, Gandhigram Rural Inst, Dept Home Sci, Dindigul 624302, Tamil Nadu, India.
   [Sankar, Muthupandi] Saveetha Univ, Saveetha Med Coll & Hosp, Saveetha Inst Med & Tech Sci SIMATS, Ctr Global Hlth Res, Chennai 602105, Tamil Nadu, India.
   [Muthupandian, Saravanan] Univ Tabuk, Fac Appl Med Sci, Dept Med Lab Technol, Tabuk 71491, Saudi Arabia.
   [Muthupandian, Saravanan] Univ Tabuk, Prince Fahad Bin Sultan Chair Biomed Res, Tabuk 71491, Saudi Arabia.
C3 Gandhigram Rural Institute; Saveetha Institute of Medical & Technical
   Science; Saveetha Medical College & Hospital; University of Tabuk;
   University of Tabuk
RP Sankar, MR (corresponding author), Deemed Be Univ, Gandhigram Rural Inst, Dept Home Sci, Dindigul 624302, Tamil Nadu, India.
EM muthurekasankar@gmail.com; ssvijayanchali20@gmail.com;
   muthupandisankar@gmail.com; bioinfosaran@gmail.com
RI S, Muthupandi/JFB-5692-2023
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NR 92
TC 0
Z9 0
U1 0
U2 0
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
EI 2731-4286
J9 DISCOV FOOD
JI Discov. Food
PD APR 1
PY 2025
VL 5
IS 1
AR 90
DI 10.1007/s44187-025-00349-y
PG 13
WC Food Science & Technology
WE Emerging Sources Citation Index (ESCI)
SC Food Science & Technology
GA 0YH2Z
UT WOS:001458899900001
DA 2025-06-11
ER

PT J
AU Adam, TC
   Epel, ES
AF Adam, Tanja C.
   Epel, Elissa S.
TI Stress, eating and the reward system
SO PHYSIOLOGY & BEHAVIOR
LA English
DT Article; Proceedings Paper
CT Annual Meeting of the Society-for-the-Study-of-Ingestive-Behavior
CY JUL 18-22, 2006
CL Naples, FL
SP Soc Study Ingest Behav
DE stress; reward; eating; cortisol; obesity
ID PITUITARY-ADRENAL AXIS; COGNITIVE DIETARY RESTRAINT; CORTISOL AWAKENING
   RESPONSE; HUMAN ADIPOSE-TISSUE; SERUM LEPTIN LEVELS; FOOD-INTAKE;
   NEUROPEPTIDE-Y; INSULIN-RESISTANCE; INTRAVENTRICULAR INSULIN; METABOLIC
   SYNDROME
AB An increasing number of people report concerns about the amount of stress in their life. At the same time obesity is an escalating health problem worldwide. Evidence is accumulating rapidly that stress related chronic stimulation of the hypothalamic-pituitary-adrenal (HPA) axis and resulting excess glucocorticoid exposure may play a potential role in the development of visceral obesity. Since adequate regulation of energy and food intake under stress is important for survival, it is not surprising that the HPA axis is not only the 'conductor' of an appropriate stress response, but is also tightly intertwined with the endocrine regulation of appetite. Here we attempt to link animal and human literatures to tease apart how different types of psychological stress affect eating. We propose a theoretical model of Reward Based Stress Eating. This model emphasizes the role of cortisol and reward circuitry on motivating calorically dense food intake, and elucidating potential neuroendocrine mediators in the relationship between stress and eating. The addiction literature suggests that the brain reward circuitry may be a key player in stress-induced food intake. Stress as well as palatable food can stimulate endogenous opioid release. In turn, opioid release appears to be part of an organisms' powerful defense mechanism protecting from the detrimental effects of stress by decreasing activity of the HPA axis and thus attenuating the stress response. Repeated stimulation of the reward pathways through either stress induced HPA stimulation, intake of highly palatable food or both, may lead to neurobiological adaptations that promote the compulsive nature of overeating. Cortisol may influence the reward value of food via neuroendocrine/peptide mediators such as leptin, insulin and neuropeptide Y (NPY). Whereas glucocorticoids are antagonized by insulin and leptin acutely, under chronic stress, that finely balanced system is dysregulated, possibly contributing to increased food intake and visceral fat accumulation. While these mechanisms are only starting to be elucidated in humans, it appears the obesity epidemic may be exacerbated by the preponderance of chronic stress, unsuccessful attempts at food restriction, and their independent and possibly synergistic effects on increasing the reward value of highly palatable food. (C) 2007 Published by Elsevier Inc.
C1 Univ Calif San Francisco, Dept Psychiat, San Francisco, CA 94143 USA.
C3 University of California System; University of California San Francisco
RP Epel, ES (corresponding author), 3333 Calif St,Ste 465, San Francisco, CA 94143 USA.
EM eepel@lppi.ucsf.edu
RI Epel, Elissa/ABI-6703-2022
FU NIMH NIH HHS [K08 MH64110-01A1] Funding Source: Medline
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NR 119
TC 1183
Z9 1440
U1 6
U2 311
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0031-9384
J9 PHYSIOL BEHAV
JI Physiol. Behav.
PD JUL 24
PY 2007
VL 91
IS 4
SI SI
BP 449
EP 458
DI 10.1016/j.physbeh.2007.04.011
PG 10
WC Psychology, Biological; Behavioral Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI); Conference Proceedings Citation Index - Science (CPCI-S); Conference Proceedings Citation Index - Social Science &amp; Humanities (CPCI-SSH)
SC Psychology; Behavioral Sciences
GA 196HS
UT WOS:000248472900014
PM 17543357
DA 2025-06-11
ER

PT J
AU Nugent, L
   Mehta, PK
   Merz, CNB
AF Nugent, Lynn
   Mehta, Puja K.
   Merz, C. Noel Bairey
TI Gender and microvascular angina
SO JOURNAL OF THROMBOSIS AND THROMBOLYSIS
LA English
DT Article
DE Microvascular angina; Microvascular coronary dysfunction; Coronary
   syndrome X; Gender; Angina; Women
ID CORONARY-ARTERY-DISEASE; ACUTE MYOCARDIAL-INFARCTION;
   C-REACTIVE-PROTEIN; CARDIAC SYNDROME-X; DOBUTAMINE STRESS
   ECHOCARDIOGRAPHY; LEFT-VENTRICULAR FUNCTION; SYNDROME EVALUATION WISE;
   ISCHEMIC-HEART-DISEASE; ST-SEGMENT DEPRESSION; CHEST-PAIN
AB There are gender differences in the presentation, diagnosis, and treatment of chest pain. When compared to men, women may have more atypical presentations of chest pain. In addition, current diagnostic tools are often not definitive regarding cardiac etiology for chest pain in women. The current diagnostic model of chest pain focuses on significant obstructions within the large coronary arteries as the cause for angina. Microvascular angina (MVA) represents an under-recognized pathophysiologic mechanism that may explain the apparent disparities and elucidate an etiology for the common finding in women of chest pain, ischemia on stress testing, and no obstructive coronary artery disease (CAD) on angiography in the presence of abnormal coronary reactivity testing. Endothelial dysfunction, estrogen deficiency, and abnormal nociception play a role in the pathophysiology of MVA. Treatments are targeted toward these underlying mechanisms. Recognizing the role gender and other pathophysiologic models of chest pain can play in the work-up and treatment of angina may identify a treatable cardiac condition, that would otherwise be discounted as non-cardiac in origin.
C1 [Nugent, Lynn; Mehta, Puja K.; Merz, C. Noel Bairey] Cedars Sinai Med Ctr, Womens Heart Ctr, Prevent Cardiac Ctr, Inst Heart, Los Angeles, CA 90048 USA.
C3 Cedars Sinai Medical Center
RP Merz, CNB (corresponding author), Cedars Sinai Med Ctr, Womens Heart Ctr, Prevent Cardiac Ctr, Inst Heart, 444 S San Vicente Blvd, Los Angeles, CA 90048 USA.
EM Noel.BaireyMerz@cshs.org
OI Bairey Merz, C. Noel/0000-0002-9933-5155
FU National Heart, Lung and Blood Institutes [N01-HV-68161, N01-HV-68162,
   N01-HV-68163, N01-HV-68164]; National Center for Research Resources
   [MO1-RR00425]; Gustavus and Louis Pfeiffer Research Foundation,
   Denville, New Jersey; Women's Guild of Cedars-Sinai Medical Center, Los
   Angeles, California; Cedars-Sinai Medical Center, Los Angeles,
   California; CV Therapeutics/Gilead
FX This work was supported by contracts from the National Heart, Lung and
   Blood Institutes, nos. N01-HV-68161, N01-HV-68162, N01-HV-68163,
   N01-HV-68164, a GCRC grant MO1-RR00425 from the National Center for
   Research Resources, and grants from the Gustavus and Louis Pfeiffer
   Research Foundation, Denville, New Jersey, the Women's Guild of
   Cedars-Sinai Medical Center, Los Angeles, California, the Edythe L.
   Broad Women's Heart Research Fellowship, Cedars-Sinai Medical Center,
   Los Angeles, California, and the Barbra Streisand Women's Cardiovascular
   Research and Education Program, Cedars-Sinai Medical Center, Los
   Angeles.Noel Bairey Merz has received grant support from CV
   Therapeutics/Gilead. The other authors have no conflict of interest.
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NR 107
TC 23
Z9 24
U1 0
U2 4
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0929-5305
EI 1573-742X
J9 J THROMB THROMBOLYS
JI J. Thromb. Thrombolysis
PD JAN
PY 2011
VL 31
IS 1
BP 37
EP 46
DI 10.1007/s11239-010-0477-1
PG 10
WC Cardiac & Cardiovascular Systems; Hematology; Peripheral Vascular
   Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Hematology
GA 703TQ
UT WOS:000286004600006
PM 20419338
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Pineda-Moncusi, M
   Dernie, F
   Dell'Isola, A
   Kamps, A
   Runhaar, J
   Swain, S
   Zhang, WY
   Englund, M
   Pitsillidou, I
   Strauss, VY
   Robinson, DE
   Prieto-Alhambra, D
   Khalid, S
AF Pineda-Moncusi, Marta
   Dernie, Francesco
   Dell'Isola, Andrea
   Kamps, Anne
   Runhaar, Jos
   Swain, Subhashisa
   Zhang, Weiya
   Englund, Martin
   Pitsillidou, Irene
   Strauss, Victoria Y.
   Robinson, Danielle E.
   Prieto-Alhambra, Daniel
   Khalid, Sara
TI Classification of patients with osteoarthritis through clusters of
   comorbidities using 633 330 individuals from Spain
SO RHEUMATOLOGY
LA English
DT Article
DE epidemiology; OA; comorbidities; clustering
ID CARDIOVASCULAR-DISEASE; MODEL-SELECTION; MULTIMORBIDITY; DISORDERS;
   COHORT; CARE; ASSOCIATION; CRITERION; MORTALITY; IMPACT
AB Objectives To explore clustering of comorbidities among patients with a new diagnosis of OA and estimate the 10-year mortality risk for each identified cluster. Methods This is a population-based cohort study of individuals with first incident diagnosis of OA of the hip, knee, ankle/foot, wrist/hand or 'unspecified' site between 2006 and 2020, using SIDIAP (a primary care database representative of Catalonia, Spain). At the time of OA diagnosis, conditions associated with OA in the literature that were found in >= 1% of the individuals (n = 35) were fitted into two cluster algorithms, k-means and latent class analysis. Models were assessed using a range of internal and external evaluation procedures. Mortality risk of the obtained clusters was assessed by survival analysis using Cox proportional hazards. Results We identified 633 330 patients with a diagnosis of OA. Our proposed best solution used latent class analysis to identify four clusters: 'low-morbidity' (relatively low number of comorbidities), 'back/neck pain plus mental health', 'metabolic syndrome' and 'multimorbidity' (higher prevalence of all studied comorbidities). Compared with the 'low-morbidity' cluster, the 'multimorbidity' cluster had the highest risk of 10-year mortality (adjusted hazard ratio [HR]: 2.19 [95% CI: 2.15, 2.23]), followed by the 'metabolic syndrome' cluster (adjusted HR: 1.24 [95% CI: 1.22, 1.27]) and the 'back/neck pain plus mental health' cluster (adjusted HR: 1.12 [95% CI: 1.09, 1.15]). Conclusion Patients with a new diagnosis of OA can be clustered into groups based on their comorbidity profile, with significant differences in 10-year mortality risk. Further research is required to understand the interplay between OA and particular comorbidity groups, and the clinical significance of such results.
C1 [Pineda-Moncusi, Marta; Dernie, Francesco; Strauss, Victoria Y.; Robinson, Danielle E.; Prieto-Alhambra, Daniel; Khalid, Sara] Univ Oxford, Ctr Stat Med, Nuffield Dept Orthopaed Rheumatol & Musculoskeleta, Oxford, England.
   [Dell'Isola, Andrea; Englund, Martin] Lund Univ, Dept Clin Sci Lund, Clin Epidemiol Unit, Orthoped, Lund, Sweden.
   [Kamps, Anne; Runhaar, Jos] Erasmus MC Univ Med Ctr Rotterdam, Dept Gen Practice, Rotterdam, Netherlands.
   [Swain, Subhashisa] Univ Oxford, Nuffield Dept Primary Care Hlth Sci, Oxford, England.
   [Zhang, Weiya] Univ Nottingham, Sch Med, Acad Rheumatol, Nottingham, England.
   [Pitsillidou, Irene] EULAR Patient Res Partner PRP, Execut Secretary Cyprus League Rheumatism, Nicosia, Cyprus.
   [Zhang, Weiya] Univ Nottingham, Pain Ctr Versus Arthrit, Nottingham, England.
   [Prieto-Alhambra, Daniel] Botnar Res Ctr, Old Rd,Headington, Oxford OX37LD, Oxfordshire, England.
C3 University of Oxford; Lund University; Erasmus University Rotterdam;
   Erasmus MC; University of Oxford; University of Nottingham; University
   of Nottingham
RP Pineda-Moncusi, M; Dernie, F; Prieto-Alhambra, D (corresponding author), Univ Oxford, Ctr Stat Med, Nuffield Dept Orthopaed Rheumatol & Musculoskeleta, Oxford, England.; Prieto-Alhambra, D (corresponding author), Botnar Res Ctr, Old Rd,Headington, Oxford OX37LD, Oxfordshire, England.
EM daniel.prietoalhambra@ndorms.ox.ac.uk
RI Englund, Martin/J-7245-2012; Zhang, Weiya/X-9481-2019; Dell'Isola,
   Andrea/Y-6165-2019
OI Khalid, Sara/0000-0002-2845-5731; Runhaar, Jos/0000-0002-6293-6707;
   Prieto-Alhambra, Daniel/0000-0002-3950-6346; Zhang,
   Weiya/0000-0003-1142-1460; Dell'Isola, Andrea/0000-0002-0319-458X;
   Kamps, Anne/0000-0002-8998-6501; Dernie, Francesco/0000-0001-5344-1967
FU Foundation for Research in Rheumatology (FOREUM)
FX This research was funded by the Foundation for Research in Rheumatology
   (FOREUM) grant (2019-2022).
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NR 51
TC 7
Z9 7
U1 0
U2 11
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1462-0324
EI 1462-0332
J9 RHEUMATOLOGY
JI RHEUMATOLOGY
PD NOV 2
PY 2023
VL 62
IS 11
BP 3592
EP 3600
DI 10.1093/rheumatology/kead038
EA OCT 2023
PG 9
WC Rheumatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Rheumatology
GA HI3Y2
UT WOS:000926223200001
PM 36688706
OA Green Published, Green Submitted, hybrid
DA 2025-06-11
ER

PT J
AU Wolf, EJ
   Sadeh, N
   Leritz, EC
   Logue, MW
   Stoop, TB
   McGlinchey, R
   Milberg, W
   Miller, MW
AF Wolf, Erika J.
   Sadeh, Naomi
   Leritz, Elizabeth C.
   Logue, Mark W.
   Stoop, Tawni B.
   McGlinchey, Regina
   Milberg, William
   Miller, Mark W.
TI Posttraumatic Stress Disorder as a Catalyst for the Association Between
   Metabolic Syndrome and Reduced Cortical Thickness
SO BIOLOGICAL PSYCHIATRY
LA English
DT Article
DE Accelerated aging; Cortical thickness; Magnetic resonance imaging;
   Metabolic syndrome; Posttraumatic stress disorder; Structural equation
   modeling
ID BODY-MASS INDEX; TYPE-2 DIABETES-MELLITUS; OXIDATIVE STRESS;
   CARDIOVASCULAR-DISEASE; PREFRONTAL CORTEX; PHYSICAL-ACTIVITY; TRAUMATIC
   STRESS; CEREBRAL-CORTEX; RISK-FACTORS; PTSD
AB BACKGROUND: Metabolic syndrome (MetS), defined by a constellation of cardiometabolic pathologies, is highly prevalent among veterans, especially veterans with posttraumatic stress disorder (PTSD), and poses a major risk for adverse health outcomes, including neurodegeneration and mortality. Given this, we evaluated 1) the association between MetS and neural integrity, indexed by cortical thickness; 2) the relationship between PTSD and MetS; and 3) whether PTSD was associated with cortical thickness indirectly through MetS.
   METHODS: The sample consisted of 346 U.S. military veterans (89.3% male; 71.4% white) who deployed to Iraq, Afghanistan, or both. Neuroimaging data were available for 274 participants.
   RESULTS: In whole-brain analyses, MetS was negatively associated with cortical thickness in two left and four right hemisphere regions, as follows: bilateral temporal lobe, including temporal pole, fusiform gyrus, and insula, and extending into occipital cortex (left hemisphere) and orbitofrontal cortex (right hemisphere); bilateral precuneus, posterior cingulate, calcarine, and occipital-parietal cortex; and right rostral anterior cingulate cortex and central sulcus/postcentral gyrus. Path models showed that PTSD predicted MetS (beta = .19, p < .001), which was associated with reduced cortical thickness (beta = -.29 to -.43, all p < .001).
   CONCLUSIONS: Results from this young veteran sample provide evidence that PTSD confers risk for cardiometabolic pathology and neurodegeneration and raise concern that this cohort may be aging prematurely and at risk for substantial medical and cognitive decline. This study highlights the need to identify the molecular mechanisms linking PTSD to MetS and effective interventions to reduce PTSD-related health comorbidities.
C1 [Wolf, Erika J.; Sadeh, Naomi; Miller, Mark W.] VA Boston Healthcare Syst, Natl Ctr PTSD, Behav Sci Div, Boston, MA USA.
   [Leritz, Elizabeth C.] VA Boston Healthcare Syst, Neuroimaging Res Vet Ctr, Boston, MA USA.
   [Leritz, Elizabeth C.; McGlinchey, Regina; Milberg, William] VA Boston Healthcare Syst, Geriatr Res Educ & Clin Ctr, Boston, MA USA.
   [Leritz, Elizabeth C.; McGlinchey, Regina; Milberg, William] VA Boston Healthcare Syst, Translat Res Ctr TBI & Stress Disorders, Boston, MA USA.
   [Logue, Mark W.] VA Boston Healthcare Syst, Res Serv, Boston, MA USA.
   [Wolf, Erika J.; Sadeh, Naomi; Miller, Mark W.] Boston Univ, Sch Med, Dept Psychiat, Boston, MA 02118 USA.
   [Logue, Mark W.] Boston Univ, Sch Med, Biomed Genet, Boston, MA 02118 USA.
   [Leritz, Elizabeth C.; McGlinchey, Regina; Milberg, William] Harvard Med Sch, Dept Psychiat, Boston, MA USA.
   [Logue, Mark W.] Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA USA.
   [Stoop, Tawni B.] Boston VA Res Inst Inc, Boston, MA USA.
C3 Harvard University; Harvard University Medical Affiliates; US Department
   of Veterans Affairs; Veterans Health Administration (VHA); VA Boston
   Healthcare System; Harvard University; Harvard University Medical
   Affiliates; US Department of Veterans Affairs; Veterans Health
   Administration (VHA); VA Boston Healthcare System; Geriatric Research
   Education & Clinical Center; Harvard University; Harvard University
   Medical Affiliates; US Department of Veterans Affairs; Veterans Health
   Administration (VHA); VA Boston Healthcare System; Harvard University;
   Harvard University Medical Affiliates; US Department of Veterans
   Affairs; Veterans Health Administration (VHA); VA Boston Healthcare
   System; Harvard University; Harvard University Medical Affiliates; US
   Department of Veterans Affairs; Veterans Health Administration (VHA); VA
   Boston Healthcare System; Boston University; Boston University; Harvard
   University; Harvard Medical School; Boston University
RP Wolf, EJ (corresponding author), VA Boston Healthcare Syst, Natl Ctr PTSD 116B2, 150 South Huntington Ave, Boston, MA 02130 USA.
EM erika.wolf@va.gov
RI Sadeh, Naomi/B-5489-2014; Miller, Mark/G-7322-2011
OI Miller, Mark/0000-0001-6393-8563; Wolf, Erika/0000-0003-2666-2435
FU National Institute of Mental Health [R21MH102834]; Translational
   Research Center for TBI and Stress Disorders; Department of Veterans
   Affairs Rehabilitation Research and Development Traumatic Brain Injury
   Center of Excellence [B9254-C]; Department of Veterans Affairs
   Cooperative Studies Program; National Institute of Neurological
   Disorders and Stroke [R01NS086882]; Department of Veterans Affairs
   Clinical Sciences Research and Development Program Career Development
   Award (EJW)
FX This work was supported by the National Institute of Mental Health Grant
   No. R21MH102834 "Neuroimaging Genetics of PTSD," Translational Research
   Center for TBI and Stress Disorders, a Department of Veterans Affairs
   Rehabilitation Research and Development Traumatic Brain Injury Center of
   Excellence (B9254-C), Department of Veterans Affairs Cooperative Studies
   Program, National Institute of Neurological Disorders and Stroke Grant
   No. R01NS086882, and Department of Veterans Affairs Clinical Sciences
   Research and Development Program Career Development Award (EJW). The
   views expressed in this article are those of the authors and do not
   necessarily reflect the position or policy of the U.S. Department of
   Veterans Affairs or the U.S. Government.
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NR 103
TC 40
Z9 44
U1 0
U2 22
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0006-3223
EI 1873-2402
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD SEP 1
PY 2016
VL 80
IS 5
BP 363
EP 371
DI 10.1016/j.biopsych.2015.11.023
PG 9
WC Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Psychiatry
GA DS5RR
UT WOS:000380840500008
PM 26826875
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Khan, SR
AF Khan, Saeed R.
TI Is oxidative stress, a link between nephrolithiasis and obesity,
   hypertension, diabetes, chronic kidney disease, metabolic syndrome?
SO UROLOGICAL RESEARCH
LA English
DT Review
DE Chronic kidney disease; Diabetes; Hypertension; Metabolic syndrome;
   Nephrolithiasis; Oxidative stress
ID RENAL EPITHELIAL-CELLS; CALCIUM-OXALATE NEPHROLITHIASIS; MONOCYTE
   CHEMOATTRACTANT PROTEIN-1; C-REACTIVE PROTEIN; SALT-SENSITIVE
   HYPERTENSION; NADPH OXIDASE SUBUNITS; STONE-FORMING PATIENTS;
   TUMOR-NECROSIS-FACTOR; INDUCED UP-REGULATION; BLOOD-PRESSURE
AB Epidemiological studies have provided the evidence for association between nephrolithiasis and a number of cardiovascular diseases including hypertension, diabetes, chronic kidney disease, metabolic syndrome. Many of the co-morbidities may not only lead to stone disease but also be triggered by it. Nephrolithiasis is a risk factor for development of hypertension and have higher prevalence of diabetes mellitus and some hypertensive and diabetic patients are at greater risk for stone formation. An analysis of the association between stone disease and other simultaneously appearing disorders, as well as factors involved in their pathogenesis, may provide an insight into stone formation and improved therapies for stone recurrence and prevention. It is our hypothesis that association between stone formation and development of co-morbidities is a result of certain common pathological features. Review of the recent literature indicates that production of reactive oxygen species (ROS) and development of oxidative stress (OS) may be such a common pathway. OS is a common feature of all cardiovascular diseases (CVD) including hypertension, diabetes mellitus, atherosclerosis and myocardial infarct. There is increasing evidence that ROS are also produced during idiopathic calcium oxalate (CaOx) nephrolithiasis. Both tissue culture and animal model studies demonstrate that ROS are produced during interaction between CaOx/calcium phosphate (CaP) crystals and renal epithelial cells. Clinical studies have also provided evidence for the development of oxidative stress in the kidneys of stone forming patients. Renal disorders which lead to OS appear to be a continuum. Stress produced by one disorder may trigger the other under the right circumstances.
C1 Univ Florida, Coll Med, Dept Pathol & Lab Med, Gainesville, FL 32610 USA.
C3 State University System of Florida; University of Florida
RP Khan, SR (corresponding author), Univ Florida, Coll Med, Dept Pathol & Lab Med, Gainesville, FL 32610 USA.
EM khan@pathology.ufl.edu
RI Stefanadis, Christodoulos/ABH-2232-2020
OI Stefanadis, Christodoulos/0000-0001-5974-6454
FU NIDDK NIH HHS [R01 DK078602] Funding Source: Medline
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NR 201
TC 148
Z9 164
U1 1
U2 52
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0300-5623
EI 1434-0879
J9 UROL RES
JI Urol. Res.
PD APR
PY 2012
VL 40
IS 2
BP 95
EP 112
DI 10.1007/s00240-011-0448-9
PG 18
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 912EW
UT WOS:000301778500001
PM 22213019
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Singh, VK
   Karmani, S
   Malo, PK
   Virupaksha, HG
   Muralidhar, D
   Venkatasubramanian, G
   Muralidharan, K
AF Singh, Vinit Kumar
   Karmani, Sneha
   Malo, Palash Kumar
   Virupaksha, H. G.
   Muralidhar, Daliboina
   Venkatasubramanian, Ganesan
   Muralidharan, Kesavan
TI Impact of lifestyle modification on some components of metabolic
   syndrome in persons with severe mental disorders: A meta-analysis
SO SCHIZOPHRENIA RESEARCH
LA English
DT Review
DE Metabolic syndrome; Weight gain; Body Mass Index; Waist circumference;
   Severe mental disorder; Lifestyle modification
ID RANDOMIZED CONTROLLED-TRIAL; WEIGHT-LOSS INTERVENTION;
   PHYSICAL-ACTIVITY; CARDIOVASCULAR-DISEASE; BEHAVIORAL-THERAPY;
   MANAGEMENT PROGRAM; BIPOLAR DISORDER; SCHIZOPHRENIA; GAIN; RISK
AB Background: Metabolic syndrome (MS) is reportedly associated with high mortality from mostly cardiovascular causes in patients with severe mental disorders (SMD). Lifestyle interventions augment effectivemanagement of MS in patients with SMD. The present meta-analysis aims at updating the recent evidence on the effectiveness of lifestyle intervention for MS in patients with SMD.
   Method: A literature search for English Language publications of randomized controlled trials (RCTs) from 2001 to 2016 comparing lifestyle modification (LM) with treatment as usual (TAU) in the management of MS were identified. Using PRISMA guidelines, 19 RCTs reporting data on 1688 SMD and MS patients and providing data on change in Body Weight, BodyMass Index (BMI) andwaist circumference (WC) were included. Using random effects model, standardizedmean difference between LM and TAU for the mean baseline-to-endpoint change in body weight, BMI andWC was calculated with a 95% confidence limit, on RevMan 5.3. The study was registered with PROSPERO (CRD42016046847).
   Results: LM had significantly superior efficacy in the reducing weight (-0.64, 95% CI -0.89, -0.39, Z = 5.03, overall effect p b 0.00001), BMI (-0.68, 95% CI -1.01, -0.35, Z = 4.05, overall effect p b 0.0001), and WC (-0.60, 95% CI -1.17, -0.03, Z = 2.06; overall effect p = 0.04), compared to TAU. LM was significantly more effective than TAU even in short duration (p = 0.0001) and irrespective of the treatment setting.
   Conclusion: Interventions targeting LM in persons with SMD and MS are effective in reducing body weight, BMI andWC. It must be routinely recommended to all patientswith SMD, ideally during commencement stage of second generation antipsychotic treatment. (C) 2018 Elsevier B.V. All rights reserved.
C1 [Karmani, Sneha; Venkatasubramanian, Ganesan; Muralidharan, Kesavan] Natl Inst Mental Hlth & Neuro Sci INI, Dept Psychiat, Bengaluru 560029, Karnataka, India.
   [Singh, Vinit Kumar; Virupaksha, H. G.; Muralidhar, Daliboina] Natl Inst Mental Hlth & Neuro Sci INI, Dept Psychiat Social Work, Bengaluru 560029, Karnataka, India.
   [Malo, Palash Kumar] Natl Inst Mental Hlth & Neuro Sci INI, Dept Biostat, Bengaluru 560029, Karnataka, India.
C3 National Institute of Mental Health & Neurosciences - India; National
   Institute of Mental Health & Neurosciences - India; National Institute
   of Mental Health & Neurosciences - India
RP Muralidharan, K (corresponding author), Natl Inst Mental Hlth & Neurosci, Bengaluru 560029, India.
EM drmuralidk@gmail.com
RI ; Venkatasubramanian, Ganesan/AAD-9117-2019
OI Malo, Palash Kumar/0000-0003-1548-6966; Venkatasubramanian,
   Ganesan/0000-0002-0949-898X
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NR 47
TC 24
Z9 25
U1 0
U2 8
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0920-9964
EI 1573-2509
J9 SCHIZOPHR RES
JI Schizophr. Res.
PD DEC
PY 2018
VL 202
BP 17
EP 25
DI 10.1016/j.schres.2018.06.066
PG 9
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA HD1UW
UT WOS:000452298400003
PM 30539768
DA 2025-06-11
ER

PT J
AU Fujita, K
   Nishizawa, H
   Funahashi, T
   Shimomura, I
   Shimabukuro, M
AF Fujita, Koichi
   Nishizawa, Hitoshi
   Funahashi, Tohru
   Shimomura, Iichiro
   Shimabukuro, Michio
TI Systemic oxidative stress is associated with visceral fat accumulation
   and the metabolic syndrome
SO CIRCULATION JOURNAL
LA English
DT Article
DE metabolic syndrome; systemic oxidative stress; urinary 8-epi-PGF2 alpha;
   visceral fat accumulation
ID C-REACTIVE PROTEIN; LOW-DENSITY-LIPOPROTEIN; ENDOTHELIAL DYSFUNCTION;
   INSULIN-RESISTANCE; LIPID-PEROXIDATION; NAD(P)H OXIDASE; BODY-FAT;
   ADIPONECTIN; OBESITY; DISEASE
AB Background The metabolic syndrome (MetS) is a major target for prevention of atherosclerotic cardiovascular diseases and visceral fat accumulation is an underlying component of MetS. The aim of this study was to investigate the association of systemic oxidative stress with visceral fat accumulation and MetS.
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C1 Osaka Univ, Grad Sch Med, Dept Metab Med, Suita, Osaka 5650871, Japan.
   Univ Ryukyus, Fac Med, Dept Internal Med 2, Okinawa, Japan.
C3 The University of Osaka; University of the Ryukyus
RP Nishizawa, H (corresponding author), Osaka Univ, Grad Sch Med, Dept Metab Med, 2-2-B5 Yamadaoka, Suita, Osaka 5650871, Japan.
EM hitoshin@imed2.med.osaka-u.ac.jp
OI Shimabukuro, Michio/0000-0001-7835-7665
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NR 49
TC 230
Z9 250
U1 0
U2 9
PU JAPANESE CIRCULATION SOC
PI TOYKO
PA 18TH FLOOR IMPERIAL HOTEL TOWER, 1-1-1 UCHISAIWAI-CHO CHIYODA-KU, TOYKO,
   100-0011, JAPAN
SN 1346-9843
EI 1347-4820
J9 CIRC J
JI Circ. J.
PD NOV
PY 2006
VL 70
IS 11
BP 1437
EP 1442
DI 10.1253/circj.70.1437
PG 6
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 100FU
UT WOS:000241654300013
PM 17062967
DA 2025-06-11
ER

PT J
AU Yahia, H
   Hassan, A
   El-Ansary, MR
   Al-Shorbagy, MY
   El-Yamany, MF
AF Yahia, Haneen
   Hassan, Azza
   El-Ansary, Mona R.
   Al-Shorbagy, Muhammad Y.
   El-Yamany, Mohamed F.
TI IL-6/STAT3 and adipokine modulation using tocilizumab in rats with
   fructose-induced metabolic syndrome
SO NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
LA English
DT Article
DE Metabolic syndrome; Interleukin 6; Tocilizumab; Fructose; Adipocyte
ID INSULIN-RESISTANCE; INTERLEUKIN-6 LEVELS; NERVOUS-SYSTEM; OBESITY;
   MECHANISMS; HYPERTENSION; INFLAMMATION; STRESS; TISSUE; IL-6
AB Metabolic syndrome (MetS) is a low-grade inflammation state that results from an interplay between genetic and environmental factors. The incidence of MetS among individuals with insulin resistance, dyslipidemia, elevated blood pressure, and obesity, which constitute the syndrome, is 40% in the Middle East. The absence of an approved therapeutic agent for MetS is one reason to investigate tocilizumab (TCZ), which might be effective in the treatment of MetS. Results have implicated interleukin 6 (IL-6) in the development of MetS, identifying inflammation as a critical factor in its etiology and offering hope for new therapeutic approaches development. Here, we evaluate whether tocilizumab can be used for metabolic syndrome treatment. We assigned rats to three groups, 8 rats each: a negative-control group, provided with standard rodent chow and water; a fructose-fed group, provided with standard rodent chow and 10% fructose in drinking water for 22 weeks; and a treatment group, fed as per the metabolic syndrome group but treated with tocilizumab (5 mg/kg/week, intraperitoneal) for the final 5 weeks. Treatment with TCZ successfully ameliorated the damaging effects of fructose by stabilizing body weight gain and through the normalization of serum biochemical parameters and histopathological examination. Significant differences in adipokine levels were perceived, resulting in a significant decline in serum leptin and interleukin 6 (IL-6) levels concurrent with adiponectin normalization. Tocilizumab might be an effective agent for the treatment of metabolic syndrome. However, further investigations on human subjects are needed before the clinical application of tocilizumab for this indication.
C1 [Yahia, Haneen] Modern Univ Technol & Informat, Fac Pharm, Dept Pharmacol & Toxicol, Cairo, Egypt.
   [Hassan, Azza] Cairo Univ, Fac Vet Med, Dept Pathol, Cairo, Egypt.
   [El-Ansary, Mona R.] Modern Univ Technol & Informat, Fac Pharm, Dept Biochem, Cairo, Egypt.
   [Al-Shorbagy, Muhammad Y.] Newgiza Univ, Sch Pharm, Giza, Egypt.
   [Al-Shorbagy, Muhammad Y.; El-Yamany, Mohamed F.] Cairo Univ, Fac Pharm, Dept Pharmacol & Toxicol, Cairo, Egypt.
C3 Egyptian Knowledge Bank (EKB); Cairo University; Newgiza University
   (NGU); Egyptian Knowledge Bank (EKB); Cairo University
RP Yahia, H (corresponding author), Modern Univ Technol & Informat, Fac Pharm, Dept Pharmacol & Toxicol, Cairo, Egypt.
EM Haneen.yahia91@gmail.com
RI Al-Shorbagy, Muhammad/R-3968-2019
OI Al-Shorbagy, Muhammad/0000-0002-5104-6821
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NR 74
TC 12
Z9 12
U1 0
U2 2
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0028-1298
EI 1432-1912
J9 N-S ARCH PHARMACOL
JI Naunyn-Schmiedebergs Arch. Pharmacol.
PD DEC
PY 2020
VL 393
IS 12
BP 2279
EP 2292
DI 10.1007/s00210-020-01940-z
EA JUL 2020
PG 14
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA OR7SU
UT WOS:000547241500001
PM 32651660
DA 2025-06-11
ER

PT J
AU Oliva-Olivera, W
   Lhamyani, S
   Coín-Aragüez, L
   Castellano-Castillo, D
   Alcaide-Torres, J
   Yubero-Serrano, EM
   El Bekay, R
   Tinahones, FJ
AF Oliva-Olivera, Wilfredo
   Lhamyani, Said
   Coin-Araguez, Leticia
   Castellano-Castillo, Daniel
   Alcaide-Torres, Juan
   Yubero-Serrano, Elena Maria
   El Bekay, Rajaa
   Tinahones, Francisco Jose
TI Neovascular deterioration, impaired NADPH oxidase and inflammatory
   cytokine expression in adipose-derived multipotent cells from subjects
   with metabolic syndrome
SO METABOLISM-CLINICAL AND EXPERIMENTAL
LA English
DT Article
DE Metabolic syndrome; ASC; HGF; VEGF; NOX
ID HEPATOCYTE GROWTH-FACTOR; INCREASED OXIDATIVE STRESS;
   SMOOTH-MUSCLE-CELLS; INSULIN-RESISTANCE; REACTIVE OXYGEN;
   OBESE-PATIENTS; STEM-CELLS; KAPPA-B; TISSUE ANGIOGENESIS;
   ENDOTHELIAL-CELLS
AB Objective. Expansion of adipose tissue depends on the growth of its vascular network and it has been shown that adipose tissue dysfunction in obese subjects with the metabolic syndrome is associated with decreased angiogenesis. However, some subjects with a high body mass index do not develop metabolic abnormalities associated with obesity. In this study we examined the neovascular properties, expression levels of protein's involved in cellular redox balance and inflammatory cytokines in adipose-derived multipotent mesenchymal cells (ASCs) of subjects with different metabolic profiles.
   Materials/methods. We applied cell culture, flow cytometry, RT-qPCR and ELISA techniques to characterize the ASCs isolated from paired biopsies of visceral (visASCs) and subcutaneous (subASCs) adipose tissue from 39 subjects grouped into normal weight (NW), obese without metabolic syndrome (NonMS) and with metabolic syndrome (MS).
   Results. VisASCs and subASCs from MS subjects showed a decrease in tubules formation capacity compared to ASCs from NonMS subjects as well as changes in the expression levels of proteins involved in cell redox balance and secretion levels of proteins linked to the senescence-associated secretory phenotype. Deterioration in the neovascular properties of subASCs from the MS subjects was also evident in the decreased levels of VEGF secretion during adipogenesis and in the effects of the conditioned medium on endothelial cell tubule formation.
   Conclusions. Our findings suggest a redox imbalance status in ASCs from subjects with metabolic syndrome and decreased their neovascular function that probably contributes to the vascular insufficiency of adipose depots. (C) 2017 Elsevier Inc. All rights reserved.
C1 [Oliva-Olivera, Wilfredo; Coin-Araguez, Leticia; Castellano-Castillo, Daniel; Alcaide-Torres, Juan; Yubero-Serrano, Elena Maria; El Bekay, Rajaa; Tinahones, Francisco Jose] Univ Malaga UMA, Hosp Malaga Virgen de la Victoria, Inst Biomed Res Malaga IBIMA, Dept Clin Endocrinol & Nutr, Malaga, Spain.
   [Oliva-Olivera, Wilfredo; Coin-Araguez, Leticia; Castellano-Castillo, Daniel; Alcaide-Torres, Juan; El Bekay, Rajaa; Tinahones, Francisco Jose] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr, Madrid, Spain.
   [Lhamyani, Said] Univ Malaga UMA, Sch Sci, Res Lab, Campus Teatinos S-N, Malaga 29010, Spain.
   [Yubero-Serrano, Elena Maria] Univ Cordoba, Reina Sofia Univ Hosp, Maimonides Inst Biomed Res Cordoba, Lipids & Atherosclerosis Unit, Cordoba, Spain.
C3 Instituto de Investigacion Biomedica de Malaga y Plataforma en
   Nanomedicina (IBIMA); Universidad de Malaga; Instituto de Salud Carlos
   III; CIBER - Centro de Investigacion Biomedica en Red; CIBEROBN;
   Universidad de Cordoba
RP Oliva-Olivera, W; El Bekay, R; Tinahones, FJ (corresponding author), Hosp Virgen de la Victoria, Res Lab, Campus Teatinos S-N,First Floor, Malaga 29010, Spain.
EM oliva_olivera@hotmail.com; elbekay@gmail.com; fjtinahones@hotmail.com
RI LHAMYANI, said/AAQ-1973-2020; YUBERO, ELENA/AFM-2738-2022;
   Castellano-Castillo, Daniel/AAA-8423-2021; Bekay, Rajaa/AAZ-3959-2020;
   Oliva-Olivera, Wilfredo/GSN-7320-2022; Tinahones,
   Francisco/AAB-2882-2020
OI Yubero-Serrano, Elena M/0000-0002-2733-5359; El Bekay Rizky,
   RAJAA/0000-0003-3332-3431; LHAMYANI, said/0000-0002-9830-9772;
   Castellano-Castillo, Daniel/0000-0001-8041-8244; Oliva Olivera,
   Wilfredo/0000-0003-3473-7898; Tinahones, Francisco J/0000-0001-6871-4403
FU European Union through the European Regional Development Fund (FEDER);
   Ministry of Economy and Competitiveness, Institute of Health Carlos III
   [PI13/02628, PI12/02355]; Ministry of Economy and Knowledge
   [PI-CTS-08181/2011, CTS-7895/2011]; ISCIII "Miguel Servet II"
   [MSII13/00041]; Ministry of Education, Culture and Sport [FPU13/04211]
FX This work was cofunded by the European Union through the European
   Regional Development Fund (FEDER) and supported by grants from the
   Ministry of Economy and Competitiveness, Institute of Health Carlos III
   (PI13/02628; PI12/02355) and the Ministry of Economy and Knowledge
   (PI-CTS-08181/2011; CTS-7895/2011). R.E.B is supported by a fellowship
   from the ISCIII "Miguel Servet II" (MSII13/00041). D.C.C is supported by
   a "Formacion de Profesorado Universitario (FPU)" predoctoral contract
   from the Ministry of Education, Culture and Sport (FPU13/04211).
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NR 48
TC 11
Z9 12
U1 1
U2 11
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0026-0495
EI 1532-8600
J9 METABOLISM
JI Metab.-Clin. Exp.
PD JUN
PY 2017
VL 71
BP 132
EP 143
DI 10.1016/j.metabol.2017.03.012
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA EW5YW
UT WOS:000402583400014
PM 28521866
DA 2025-06-11
ER

PT J
AU Voruganti, VS
   Cai, GW
   Klohe, DM
   Jordan, KC
   Lane, MA
   Freeland-Graves, JH
AF Voruganti, Venkata Saroja
   Cai, Guowen
   Klohe, Deborah M.
   Jordan, Kristine C.
   Lane, Michelle A.
   Freeland-Graves, Jeanne H.
TI Short-term weight loss in overweight/obese low-income women improves
   plasma zinc and metabolic syndrome risk factors
SO JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
LA English
DT Article
DE Obesity; Intervention; Body fat
ID OBESE CHILDREN; INSULIN-RESISTANCE; NUTRITIONAL-STATUS; OXIDATIVE
   STRESS; ELITE FEMALE; BODY-FAT; LEPTIN; COPPER; SUPPLEMENTATION;
   ASSOCIATION
AB Metabolic syndrome is a group of disorders involving obesity, insulin resistance, dyslipidemia and hypertension. Obesity is the most crucial risk factor of metabolic syndrome, because it is known to precede other risk factors. Obesity is also associated with disturbances in the metabolism of the trace mineral, zinc. The overall purpose of this study was to investigate the effects of short-term weight loss on plasma zinc and metabolic syndrome risk factors. An 8-week weight loss intervention study was conducted with 90 low-income overweight/obese mothers, whose youngest child was 1-3 years old. Plasma levels of zinc, glucose, insulin, leptin, triglycerides, total, high-density lipoprotein (HDL) and low-density lipoprotein (LDL) cholesterol were measured and compared at weeks 0 and 8 of the weight loss program. At pre-study, plasma zinc was low in 39% and, within normal values in 46%, of obese/overweight mothers. By the end of intervention, plasma zinc rose by 22% and only 5% of the mothers continued to exhibit low plasma zinc. At post-study, the metabolic syndrome risk factors of waist circumference, HDL cholesterol, and diastolic blood pressure (p < 0.05) showed significant improvements. Plasma zinc increased by a greater margin (67%) in women with low zinc, as compared to those with normal zinc (18%); weight reduction was similar in both the groups. Finally, changes in % body fat were related negatively with changes in plasma zinc (r = -0.28, p < 0.05). The circulating levels of zinc, as well as the metabolic syndrome components, showed significant improvements in overweight/obese low-income women after weight loss. (C) 2010 Elsevier GmbH. All rights reserved.
C1 [Voruganti, Venkata Saroja] SW Fdn Biomed Res, Dept Genet, San Antonio, TX 78227 USA.
   [Cai, Guowen] SAS Inst, Cary, NC 27513 USA.
   [Klohe, Deborah M.; Freeland-Graves, Jeanne H.] Univ Texas Austin, Dept Nutr Sci, Austin, TX 78712 USA.
   [Jordan, Kristine C.] Univ Utah, Coll Hlth, Div Nutr, Salt Lake City, UT 84112 USA.
   [Lane, Michelle A.] Texas State Univ, Dept Family & Consumer Sci, Nutr & Foods Program, San Marcos, TX 78666 USA.
C3 Texas Biomedical Research Institute; SAS Institute Inc; University of
   Texas System; University of Texas Austin; Utah System of Higher
   Education; University of Utah; Texas State University System; Texas
   State University San Marcos
RP Voruganti, VS (corresponding author), SW Fdn Biomed Res, Dept Genet, POB 760549, San Antonio, TX 78245 USA.
EM svorugan@sfbrgenetics.org
FU Texas Higher Education Coordinating Board, Austin, TX [00-377]
FX This research is supported by a grant from the Texas Higher Education
   Coordinating Board, Austin, TX (UTA #00-377).
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NR 48
TC 17
Z9 17
U1 0
U2 4
PU ELSEVIER GMBH, URBAN & FISCHER VERLAG
PI JENA
PA OFFICE JENA, P O BOX 100537, 07705 JENA, GERMANY
SN 0946-672X
J9 J TRACE ELEM MED BIO
JI J. Trace Elem. Med. Biol.
PY 2010
VL 24
IS 4
BP 271
EP 276
DI 10.1016/j.jtemb.2010.05.001
PG 6
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 703YP
UT WOS:000286018200008
PM 20692822
DA 2025-06-11
ER

PT J
AU Mackness, B
   Quarck, R
   Verreth, W
   Mackness, M
   Holvoet, P
AF Mackness, Bharti
   Quarck, Rozenn
   Verreth, Wim
   Mackness, Mike
   Holvoet, Paul
TI Human paraoxonase-1 overexpression inhibits atherosclerosis in a mouse
   model of metabolic syndrome
SO ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
LA English
DT Article
DE atherosclerosis; metabolic syndrome; oxidized LDL; paraoxonase-1
ID LOW-DENSITY-LIPOPROTEIN; HUMAN SERUM PARAOXONASE; OXIDIZED LDL;
   OXIDATIVE MODIFICATION; BIOLOGICAL-ACTIVITY; GENE-TRANSFER; CORONARY;
   PON1; PROTECTION; PROTEIN
AB Background - The metabolic syndrome is typified by obesity, dyslipidemia, diabetes, hypertension, increased oxidative stress, and accelerated atherosclerosis. Paraoxonase1 (PON1), a high-density lipoprotein (HDL)-associated antioxidant enzyme that prevents the oxidation of low-density lipoprotein (LDL), is low in the metabolic syndrome.
   Methods and Results - We used adenovirus-mediated PON1 gene transfer (AdPON1) to overexpress human PON1 in mice with combined leptin and LDL receptor deficiency, a model of metabolic syndrome. PON1 activity, plasma lipids, the titer of autoantibodies against malondialdehyde (MDA)-modified LDL, and atherosclerosis in AdPON1 mice were compared with these in mice that received a control recombinant adenovirus (AdRR5). PON1 activity was increased 4.4-fold (P < 0.001) in AdPON1 mice (N = 12), whereas in AdRR5 mice (N = 11) activity did not change. Expressing human PON1 significantly reduced the total plaque volume, the volume of plaque macrophages, and of plaque-associated oxidized LDL. It increased the percentage of smooth muscle cells in the plaques. Expressing human PON1 lowered the titer of autoantibodies against MDA-modified LDL, a proxy for oxidized LDL in mice. It had no overall effect on plasma total cholesterol and triglycerides, as evidenced by the similar area under the curves, and on the HDL distribution profile.
   Conclusion - Our data suggest that in this mouse model of metabolic syndrome, expressing human PON1 inhibited the development of atherosclerosis, probably by reducing the amount of oxidized LDL in plasma and in the plaque, thereby preventing its proatherogenic effects. Adenovirus-mediated gene transfer of human PON1 may be a potential and useful tool to prevent/retard atherosclerosis in humans.
C1 Manchester Royal Infirm, Univ Dept Med, Manchester M13 9WL, Lancs, England.
   Katholieke Univ Leuven, Dept Cardiovasc Dis, Atherosclerosis & Metab Unit, Louvain, Belgium.
C3 University of Manchester; KU Leuven
RP Mackness, M (corresponding author), Manchester Royal Infirm, Univ Dept Med, Oxford Rd, Manchester M13 9WL, Lancs, England.
EM bharti.mackness@cmmc.nhs.uk
RI HOLVOET, PAUL/T-8434-2017; Quarck, Rozenn/J-8067-2018
OI Holvoet, Paul/0000-0001-9201-0772; Quarck, Rozenn/0000-0002-8293-6261
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NR 39
TC 143
Z9 155
U1 0
U2 10
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1079-5642
EI 1524-4636
J9 ARTERIOSCL THROM VAS
JI Arterioscler. Thromb. Vasc. Biol.
PD JUL
PY 2006
VL 26
IS 7
BP 1545
EP 1550
DI 10.1161/01.ATV.0000222924.62641.aa
PG 6
WC Hematology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Hematology; Cardiovascular System & Cardiology
GA 124YO
UT WOS:000243408900021
PM 16627808
OA Bronze
DA 2025-06-11
ER

PT J
AU Hashim, KN
   Chin, KY
   Ahmad, F
AF Hashim, Khairun-Nisa
   Chin, Kok-Yong
   Ahmad, Fairus
TI The Mechanism of Honey in Reversing Metabolic Syndrome
SO MOLECULES
LA English
DT Review
DE metabolic syndrome; honey; obesity; hyperglycaemia; hyperlipidaemia;
   obesity; hypertension
ID TOTAL PHENOLIC CONTENTS; FATTY-ACID SYNTHASE; STINGLESS BEE HONEY;
   KAPPA-B-KINASE; INSULIN-RESISTANCE; OXIDATIVE STRESS; HEPATIC STEATOSIS;
   LIPID-METABOLISM; IRON-CHELATION; ADIPOSE-TISSUE
AB Metabolic syndrome is a constellation of five risk factors comprising central obesity, hyperglycaemia, dyslipidaemia, and hypertension, which predispose a person to cardiometabolic diseases. Many studies reported the beneficial effects of honey in reversing metabolic syndrome through its antiobesity, hypoglycaemic, hypolipidaemic, and hypotensive actions. This review aims to provide an overview of the mechanism of honey in reversing metabolic syndrome. The therapeutic effects of honey largely depend on the antioxidant and anti-inflammatory properties of its polyphenol and flavonoid contents. Polyphenols, such as caffeic acid, p-coumaric acid, and gallic acid, are some of the phenolic acids known to have antiobesity and antihyperlipidaemic properties. They could inhibit the gene expression of sterol regulatory element-binding transcription factor 1 and its target lipogenic enzyme, fatty acid synthase (FAS). Meanwhile, caffeic acid and quercetin in honey are also known to reduce body weight and fat mass. In addition, fructooligosaccharides in honey are also known to alter lipid metabolism by reducing FAS activity. The fructose and phenolic acids might contribute to the hypoglycaemic properties of honey through the phosphatidylinositol 3-kinase/protein kinase B insulin signalling pathway. Honey can increase the expression of Akt and decrease the expression of nuclear factor-kappa B. Quercetin, a component of honey, can improve vasodilation by enhancing nitric oxide production via endothelial nitric oxide synthase and stimulate calcium-activated potassium channels. In conclusion, honey can be used as a functional food or adjuvant therapy to prevent and manage metabolic syndrome.
C1 [Hashim, Khairun-Nisa; Ahmad, Fairus] Univ Kebangsaan Malaysia, Dept Anat, Fac Med, Jalan Yaacob Latif, Kuala Lumpur 56000, Malaysia.
   [Chin, Kok-Yong] Univ Kebangsaan Malaysia, Dept Pharmacol, Fac Med, Jalan Yaacob Latif, Kuala Lumpur 56000, Malaysia.
C3 Universiti Kebangsaan Malaysia; Universiti Kebangsaan Malaysia
RP Ahmad, F (corresponding author), Univ Kebangsaan Malaysia, Dept Anat, Fac Med, Jalan Yaacob Latif, Kuala Lumpur 56000, Malaysia.
EM khairunnisabthashim@gmail.com; chinkokyong@ppukm.ukm.edu.my;
   fairusahmad@ukm.edu.my
RI Chin, Kok-Yong/B-6309-2015
OI Chin, Kok-Yong/0000-0001-6628-1552; Ahmad, Fairus/0000-0002-2452-6459
FU Dana Fundamental, Faculty of Medicine [FF-2020-493]; Geran Galakan
   Penyelidik, Centre for Research and Instrumentation Management (CRIM),
   Universiti Kebangsaan Malaysia [GGP-2017-05]
FX This work was support by the Dana Fundamental, Faculty of Medicine
   (FF-2020-493) and Geran Galakan Penyelidik, Centre for Research and
   Instrumentation Management (CRIM) (GGP-2017-05), Universiti Kebangsaan
   Malaysia.
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NR 118
TC 21
Z9 22
U1 1
U2 24
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1420-3049
J9 MOLECULES
JI Molecules
PD FEB
PY 2021
VL 26
IS 4
AR 808
DI 10.3390/molecules26040808
PG 16
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA QP9MC
UT WOS:000624152000001
PM 33557218
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Katayama, T
   Sueta, D
   Kataoka, K
   Hasegawa, Y
   Koibuchi, N
   Toyama, K
   Uekawa, K
   Ma, MJ
   Nakagawa, T
   Maeda, M
   Ogawa, H
   Kim-Mitsuyama, S
AF Katayama, Tetsuji
   Sueta, Daisuke
   Kataoka, Keiichiro
   Hasegawa, Yu
   Koibuchi, Nobutaka
   Toyama, Kensuke
   Uekawa, Ken
   Ma MingJie
   Nakagawa, Takashi
   Maeda, Masanobu
   Ogawa, Hisao
   Kim-Mitsuyama, Shokei
TI Long-Term Renal Denervation Normalizes Disrupted Blood Pressure
   Circadian Rhythm and Ameliorates Cardiovascular Injury in a Rat Model of
   Metabolic Syndrome
SO JOURNAL OF THE AMERICAN HEART ASSOCIATION
LA English
DT Article
DE circadian rhythm; hypertension; obesity; renin; sodium
ID SYMPATHETIC-NERVOUS-SYSTEM; HYPERTENSIVE-RATS; SALT; NEPHROPATHY;
   MECHANISMS; ABLATION; RECEPTOR; DIPPER
AB Background-Although renal denervation significantly reduces blood pressure in patients with resistant hypertension, the role of the renal nerve in hypertension with metabolic syndrome is unknown. We investigated the impact of long-term renal denervation on SHR/NDmcr-cp(+/+) (SHRcp) rats, a useful rat model of metabolic syndrome, to determine the role of the renal nerve in hypertension with metabolic syndrome.
   Methods and Results-SHRcp rats were divided into (1) a renal denervation (RD) group and (2) a sham operation group (control) to examine the effects of long-term RD on blood pressure circadian rhythm, renal sodium retention-related molecules, the renin-angiotensin-aldosterone system, metabolic disorders, and organ injury. RD in SHRcp rats not only significantly reduced blood pressure but also normalized blood pressure circadian rhythm from the nondipper to the dipper type, and this improvement was associated with an increase in urinary sodium excretion and the suppression of renal Na+-Cl- cotransporter upregulation. RD significantly reduced plasma renin activity. RD significantly prevented cardiovascular remodeling and impairment of vascular endothelial function and attenuated cardiovascular oxidative stress. However, RD failed to ameliorate obesity, metabolic disorders, and renal injury and failed to reduce systemic sympathetic activity in SHRcp rats.
   Conclusions-By including the upregulation of the Na+-Cl- cotransporter, the renal sympathetic nerve is involved in the disruption of blood pressure circadian rhythm as well as hypertension in metabolic syndrome. Thus, RD seems to be a useful therapeutic strategy for hypertension with metabolic syndrome.
C1 [Katayama, Tetsuji; Sueta, Daisuke; Kataoka, Keiichiro; Hasegawa, Yu; Koibuchi, Nobutaka; Toyama, Kensuke; Uekawa, Ken; Ma MingJie; Nakagawa, Takashi; Kim-Mitsuyama, Shokei] Kumamoto Univ, Grad Sch Med Sci, Dept Pharmacol & Mol Therapeut, Kumamoto 8608556, Japan.
   [Ogawa, Hisao] Kumamoto Univ, Grad Sch Med Sci, Dept Cardiovasc Med, Kumamoto 8608556, Japan.
   [Maeda, Masanobu] Wakayama Med Univ, Sch Med, Dept Physiol, Wakayama, Japan.
C3 Kumamoto University; Kumamoto University; Wakayama Medical University
RP Kim-Mitsuyama, S (corresponding author), Kumamoto Univ, Grad Sch Med Sci, Dept Pharmacol & Mol Therapeut, 1-1-1 Honjo, Kumamoto 8608556, Japan.
EM kimmitsu@gpo.kumamoto-u.ac.jp
RI Nakagawa, Takashi/F-3015-2010; Uekawa, Ken/LEM-7766-2024; Sueta,
   Daisuke/ABG-9809-2021
FU Ministry of Education, Culture, Sports, Science, and Technology
   [23390058]; Japan Cardiovascular Research Foundation; Grants-in-Aid for
   Scientific Research [23390058] Funding Source: KAKEN
FX This work was supported by Grants-in-Aid for Scientific Research from
   the Ministry of Education, Culture, Sports, Science, and Technology
   (23390058) and the Japan Cardiovascular Research Foundation.
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NR 45
TC 45
Z9 47
U1 0
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2047-9980
J9 J AM HEART ASSOC
JI J. Am. Heart Assoc.
PD AUG
PY 2013
VL 2
IS 4
AR e000197
DI 10.1161/JAHA.113.000197
PG 14
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 243TP
UT WOS:000326340900017
PM 23974905
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Lemche, E
   Chaban, OS
   Lemche, AV
AF Lemche, Erwin
   Chaban, Oleg S.
   Lemche, Alexandra V.
TI Neuroendorine and Epigenetic Mechanisms Subserving Automatic Imbalance
   and HPA Dysfunction in the Metabolic Syndrome
SO FRONTIERS IN NEUROSCIENCE
LA English
DT Review
DE metabolic syndrome; sympathetic autonomic nervous system; stress
   neuropsychobiology; hypothalamic-ptuitary drenocortical axis; epigenetic
   programming; gene regulation; microRNA; pathophysiology
ID CORTICOTROPIN-RELEASING HORMONE; SYMPATHETIC-NERVOUS-SYSTEM;
   AGOUTI-RELATED PROTEIN; CORONARY-HEART-DISEASE; 11-BETA-HYDROXYSTEROID
   DEHYDROGENASE TYPE-1; POSTTRAUMATIC-STRESS-DISORDER;
   ENDOPLASMIC-RETICULUM STRESS; LEPTIN RECEPTOR GENE; HUMAN ADIPOCYTE
   DIFFERENTIATION; HYPOTHALAMIC ARCUATE NUCLEUS
AB Impact of environmental stress upon pathophysiology of the metabolic syndrome (MetS) has been substantiated by epidemiological, psychophysiological, and endocrinological studies. This review discusses recent advances in the understanding of causative roles of nutritional factors, sympathomedullo-adrenal (SMA) and hypothalamic-pituitary adrenocortical (HPA) axes, and adipose tissue chronic low-grade inflammation processes in MetS. Disturbances in the neuroendocrine systems for leptin, melanocortin, and neuropeptide Y (NPY)/agouti-related protein systems have been found resulting directly in MetS-like conditions. The review identifies candidate risk genes from factors shown critical for the functioning of each of these neuroendocrine signaling cascades. In its meta-analytic part, recent studies in epigenetic modification (histone methylation, acetylation, phosphorylation, ubiquitination) and posttranscriptional gene regulation by microRNAs are evaluated. Several studies suggest modification mechanisms of early life stress (ELS) and diet-induced obesity (DIO) programming in the hypothalamic regions with populations of POMC-expressing neurons. Epigenetic modifications were found in cortisol (here HSD11B1 expression), melanocortin, leptin, NPY, and adiponectin genes. With respect to adiposity genes, epigenetic modifications were documented for fat mass gene cluster APOA1/C3/A4/A5, and the lipolysis gene LIPE. With regard to inflammatory, immune and subcellular metabolism, PPARG, NKBF1, TNFA, TCF7C2, and those genes expressing cytochrome P450 family enzymes involved in steroidogenesis and in hepatic lipoproteins were documented for epigenetic modifications.
C1 [Lemche, Erwin] Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Psychosis Studies, Sect Cognit Neuropsychiat, London WC2R 2LS, England.
   [Chaban, Oleg S.] Bogomolets Natl Med Univ, Sect Psychosomat Med, Kiev, Ukraine.
   [Lemche, Alexandra V.] Inst Clin Res, Dept Med Sci, Berlin, Germany.
C3 University of London; King's College London; Bogomolets National Medical
   University
RP Lemche, E (corresponding author), Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Psychosis Studies, Sect Cognit Neuropsychiat, London WC2R 2LS, England.
EM erwin.lemche@kcl.ac.uk
RI Chaban, Oleg/ABA-8319-2020
OI Chaban, Oleg/0000-0001-9702-7629
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NR 364
TC 32
Z9 34
U1 1
U2 37
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1662-453X
J9 FRONT NEUROSCI-SWITZ
JI Front. Neurosci.
PD APR 14
PY 2016
VL 10
AR 142
DI 10.3389/fnins.2016.00142
PG 27
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA DJ1NV
UT WOS:000373971000001
PM 27147943
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Tomaro-Duchesneau, C
   Saha, S
   Malhotra, M
   Jones, ML
   Labbé, A
   Rodes, L
   Kahouli, I
   Prakash, S
AF Tomaro-Duchesneau, Catherine
   Saha, Shyamali
   Malhotra, Meenakshi
   Jones, Mitchell L.
   Labbe, Alain
   Rodes, Laetitia
   Kahouli, Imen
   Prakash, Satya
TI Effect of orally administered L. fermentum NCIMB 5221 on
   markers of metabolic syndrome: an in vivo analysis using ZDF rats
SO APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
LA English
DT Article
DE Ferulic acid esterase; L. fermentum; Metabolic syndrome; Probiotic;
   Zucker diabetic fatty rat; Microbiome; Gut microbiota
ID 3RD NATIONAL-HEALTH; FERULIC ACID; INSULIN-RESISTANCE;
   LACTOBACILLUS-ACIDOPHILUS; OXIDATIVE STRESS; PROBIOTIC DAHI; ESTERASE;
   GLUCOSE; VITRO; FORMULATION
AB Metabolic syndrome, encompassing type 2 diabetes mellitus and cardiovascular disease, is a growing health concern of industrialized countries. Ferulic acid (FA) is a phenolic acid found in foods normally consumed by humans that has demonstrated antioxidant activity, cholesterol-lowering capabilities, and anti-tumorigenic properties. Select probiotic bacteria, including Lactobacillus fermentum NCIMB 5221, produce FA due to intrinsic ferulic acid esterase activity. The aim of the present research was to investigate a FA-producing probiotic, L. fermentum NCIMB 5221, as a biotherapeutic for metabolic syndrome. The probiotic formulation was administered daily for 8 weeks to Zucker diabetic fatty (ZDF) rats, a model of hyperlipidemia and hyperglycemia. Results show that the probiotic formulation reduced fasting insulin levels and insulin resistance, significantly reduced serum triglycerides (p = 0.016), lowered serum low-density lipoprotein cholesterol levels (p = 0.008), and significantly reduced the atherogenic (p = 0.016) and atherosclerosis (p = 0.012) index as compared to the control animals. In addition, the probiotic formulation significantly increased high-density lipoprotein cholesterol levels (p = 0.041) as compared to the control animals. This research indicates that administration of the FA-producing L. fermentum NCIMB 5221 has the potential to reduce insulin resistance, hyperinsulinemia, hypercholesterolemia, and other markers involved in the pathogenesis of metabolic syndrome. Further studies are required to investigate the human clinical potential of the probiotic formulation in affecting the markers and pathogenesis of metabolic syndrome.
C1 [Tomaro-Duchesneau, Catherine; Saha, Shyamali; Malhotra, Meenakshi; Jones, Mitchell L.; Labbe, Alain; Rodes, Laetitia; Kahouli, Imen; Prakash, Satya] McGill Univ, Dept Biomed Engn, Dept Physiol, Biomed Technol & Cell Therapy Res Lab, Montreal, PQ H3A 2B4, Canada.
   [Tomaro-Duchesneau, Catherine; Saha, Shyamali; Malhotra, Meenakshi; Jones, Mitchell L.; Labbe, Alain; Rodes, Laetitia; Kahouli, Imen; Prakash, Satya] McGill Univ, Fac Med, Artificial Cells & Organs Res Ctr, Montreal, PQ H3A 2B4, Canada.
   [Saha, Shyamali] McGill Univ, Fac Dent, Montreal, PQ H3A 2B4, Canada.
   [Kahouli, Imen] McGill Univ, Fac Med, Dept Expt Med, Montreal, PQ H3A 2B4, Canada.
C3 McGill University; McGill University; McGill University; McGill
   University
RP Prakash, S (corresponding author), McGill Univ, Dept Biomed Engn, Dept Physiol, Biomed Technol & Cell Therapy Res Lab, 3775 Univ St, Montreal, PQ H3A 2B4, Canada.
EM satya.prakash@mcgill.ca
RI Malhotra, Meenakshi/LWI-4908-2024; Tomaro-Duchesneau,
   Catherine/H-2839-2019
OI Tomaro-Duchesneau, Catherine/0000-0001-5811-3268
FU Canadian Institute of Health Research (CIHR) [MPO 64308]; Micropharma
   Limited; Natural Sciences and Engineering Research Council of Canada
   (NSERC); Fonds de recherche du Quebec-Sante (FRSQ)
FX The authors would like to acknowledge a Canadian Institute of Health
   Research (CIHR) grant (MPO 64308) and grants from Micropharma Limited to
   Dr. Satya Prakash, a Doctoral Alexander Graham Bell Canada Graduate
   Scholarship from the Natural Sciences and Engineering Research Council
   of Canada (NSERC) to Catherine Tomaro-Duchesneau, and Fonds de recherche
   du Quebec-Sante (FRSQ) Doctoral awards to Meenakshi Malhotra and
   Laetitia Rodes. The authors acknowledge Daniel Marinescu, Adrian Moores,
   Erminia di Pietro, and all of the animal health technicians at McGill
   University in the Lyman Duff Medical Building animal facility for their
   help during the animal procedures. The authors would also like to
   acknowledge Dr. Mark Hancock from the McGill University Sheldon
   Biotechnology Centre for his help with the assays using the Sector (R)
   Imager 2400.
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NR 56
TC 59
Z9 72
U1 1
U2 34
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0175-7598
EI 1432-0614
J9 APPL MICROBIOL BIOT
JI Appl. Microbiol. Biotechnol.
PD JAN
PY 2014
VL 98
IS 1
BP 115
EP 126
DI 10.1007/s00253-013-5252-8
PG 12
WC Biotechnology & Applied Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology
GA 281II
UT WOS:000329093600011
PM 24121931
DA 2025-06-11
ER

PT J
AU Lambert, GW
   Straznicky, NE
   Lambert, EA
   Dixon, JB
   Schlaich, MP
AF Lambert, Gavin W.
   Straznicky, Nora E.
   Lambert, Elisabeth A.
   Dixon, John B.
   Schlaich, Markus P.
TI Sympathetic nervous activation in obesity and the metabolic
   syndrome-Causes, consequences and therapeutic implications
SO PHARMACOLOGY & THERAPEUTICS
LA English
DT Review
DE Overweight; Metabolic syndrome; Sympathetic nervous system;
   Microneurography; Target organ damage
ID BODY-MASS-INDEX; CONVERTING ENZYME-INHIBITION; POSITIVE AIRWAY PRESSURE;
   LEFT-VENTRICULAR MASS; CARDIOVASCULAR RISK-FACTORS; PREDICT
   INSULIN-RESISTANCE; MAJOR DEPRESSIVE DISORDER; SLEEP-APNEA SYNDROME; 3RD
   NATIONAL-HEALTH; END-POINT REDUCTION
AB The world wide prevalence of obesity and the metabolic syndrome is escalating. Contrary to earlier experimental evidence, human obesity is characterised by sympathetic nervous activation, with the outflows to both the kidney and skeletal muscle being activated. While the mechanisms responsible for initiating the sympathetic activation remain to be unequivocally elucidated, hyperinsulinemia, obstructive sleep apnoea, increased circulating adipokines, stress and p adrenergic receptor polymorphisms are implicated. The pattern of sympathetic activation may be the pathophysiological mechanism underpinning much obesity-related illnesses with the consequences including, amongst others, the development of hypertension, insulin resistance, diastolic dysfunction and renal impairment. While diet and exercise are the first line therapy for the treatment of obesity and the metabolic syndrome, pharmacological interventions targeting the sympathetic nervous system, either directly or indirectly are also likely to be of benefit. Importantly, the benefit may not necessarily be weight related but may be associated with a reduction in end organ damage. (C) 2010 Elsevier Inc. All rights reserved.
C1 [Lambert, Gavin W.; Straznicky, Nora E.; Lambert, Elisabeth A.; Dixon, John B.; Schlaich, Markus P.] Baker IDI Heart & Diabet Inst, Human Neurotransmitters Lab, Melbourne, Vic 8008, Australia.
   [Straznicky, Nora E.; Lambert, Elisabeth A.; Schlaich, Markus P.] Baker IDI Heart & Diabet Inst, Neurovasc Hypertens Lab, Melbourne, Vic 8008, Australia.
   [Straznicky, Nora E.; Lambert, Elisabeth A.; Schlaich, Markus P.] Baker IDI Heart & Diabet Inst, Kidney Dis Lab, Melbourne, Vic 8008, Australia.
   [Dixon, John B.] Monash Univ, Obes Res Ctr, Dept Gen Practice, Clayton, Vic 3800, Australia.
C3 Baker Heart and Diabetes Institute; Baker Heart and Diabetes Institute;
   Baker Heart and Diabetes Institute; Monash University
RP Lambert, GW (corresponding author), Baker IDI Heart & Diabet Inst, Human Neurotransmitters Lab, POB 6492,St Kilda Rd Cent, Melbourne, Vic 8008, Australia.
EM gavin.lambert@bakeridi.edu.au
RI Straznicky, Nora/E-7484-2010; Lambert, Elisabeth/E-7463-2010; Lambert,
   Gavin/Q-4869-2017; Dixon, John/A-5318-2011; Schlaich, Markus/E-7468-2010
OI Lambert, Elisabeth/0000-0002-2232-9048; Lambert,
   Gavin/0000-0003-0315-645X; Dixon, John/0000-0001-6399-7010; Schlaich,
   Markus/0000-0002-1765-0195
FU National Health and Research Council of Australia (NHMRC); National
   Heart Foundation of Australia; Solvay Pharmaceuticals; Servier; Ardian
   Inc; Allergan; Scientific Intake
FX This work was supported by grants from the National Health and Research
   Council of Australia (NHMRC) and the National Heart Foundation of
   Australia. Drs G Lambert, Dixon and Schlaich are NHMRC Senior Research
   Fellows and Dr E Lambert holds an NHMRC RD Wright Fellowship. Dr Dixon
   serves as a consultant to Allergan, Dr Schlaich serves on the advisory
   boards of Solvay and Novartis in Australia. The investigators have
   received research funding from commercial sponsors including: Solvay
   Pharmaceuticals, Servier, Ardian Inc, Allergan and Scientific Intake.
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NR 247
TC 247
Z9 267
U1 0
U2 20
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0163-7258
EI 1879-016X
J9 PHARMACOL THERAPEUT
JI Pharmacol. Ther.
PD MAY
PY 2010
VL 126
IS 2
BP 159
EP 172
DI 10.1016/j.pharmthera.2010.02.002
PG 14
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 594QK
UT WOS:000277552100004
PM 20171982
DA 2025-06-11
ER

PT J
AU Kleinridders, A
   Ferris, HA
   Cai, WK
   Kahn, CR
AF Kleinridders, Andre
   Ferris, Heather A.
   Cai, Weikang
   Kahn, C. Ronald
TI Insulin Action in Brain Regulates Systemic Metabolism and Brain Function
SO DIABETES
LA English
DT Article
ID CENTRAL-NERVOUS-SYSTEM; LONG-TERM DEPRESSION; GROWTH-FACTOR-I;
   HIPPOCAMPAL SYNAPTIC PLASTICITY; INTRANASAL INSULIN; ALZHEIMERS-DISEASE;
   LIFE-SPAN; RECEPTOR SUBSTRATE-2; SIGNALING MECHANISMS; OXIDATIVE STRESS
AB Insulin receptors, as well as IGF-1 receptors and their postreceptor signaling partners, are distributed throughout the brain. Insulin acts on these receptors to modulate peripheral metabolism, including regulation of appetite, reproductive function, body temperature, white fat mass, hepatic glucose output, and response to hypoglycemia. Insulin signaling also modulates neurotransmitter channel activity, brain cholesterol synthesis, and mitochondrial function. Disruption of insulin action in the brain leads to impairment of neuronal function and synaptogenesis. In addition, insulin signaling modulates phosphorylation of tau protein, an early component in the development of Alzheimer disease. Thus, alterations in insulin action in the brain can contribute to metabolic syndrome, and the development of mood disorders and neurodegenerative diseases.
C1 [Kahn, C. Ronald] Harvard Univ, Sch Med, Joslin Diabet Ctr, Sect Integrat Physiol & Metab, Boston, MA 02115 USA.
   Harvard Univ, Sch Med, Dept Med, Boston, MA USA.
C3 Harvard University; Harvard Medical School; Harvard University Medical
   Affiliates; Joslin Diabetes Center, Inc.; Harvard University; Harvard
   Medical School
RP Kahn, CR (corresponding author), Harvard Univ, Sch Med, Joslin Diabet Ctr, Sect Integrat Physiol & Metab, Boston, MA 02115 USA.
EM c.ronald.kahn@joslin.harvard.edu
RI Kahn, Ronald/AAY-2435-2021; Cai, Weikang/K-2394-2019; Ferris,
   Heather/L-4697-2019
OI Cai, Weikang/0000-0001-5638-0805; Ferris, Heather/0000-0002-6321-3447;
   Kleinridders, Andre/0000-0002-4248-6366
FU National Institutes of Health [DK-31036, DK-33201, DK-55545,
   5K08-DK-097293-02]; Mary K. Iacocca Professorship; Deutsche
   Forschungsgemeinschaft [KL-2399/1-1]
FX This research was supported by National Institutes of Health grants
   DK-31036, DK-33201, DK-55545, and 5K08-DK-097293-02; a Mary K. Iacocca
   Professorship; and Deutsche Forschungsgemeinschaft grant project
   KL-2399/1-1.
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NR 126
TC 476
Z9 529
U1 5
U2 90
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0012-1797
EI 1939-327X
J9 DIABETES
JI Diabetes
PD JUL
PY 2014
VL 63
IS 7
BP 2232
EP 2243
DI 10.2337/db14-0568
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA AJ7YO
UT WOS:000337918200014
PM 24931034
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Kwon, Y
   Hong, KH
   Park, YK
   Kim, S
AF Kwon, Yongseok
   Hong, Kyung Hee
   Park, Yoo-Kyung
   Kim, Sohye
TI How Does the Frequency of Eating-Alone among Older People in Korea
   Affect Their Health and Dietary Behavior?
SO NUTRIENTS
LA English
DT Article
DE eating alone; mental health; old people; Korea National Health and
   Nutrition Examination Survey (KHANES)
ID METABOLIC SYNDROME; DEPRESSION; ADULTS; OBESITY; LIFE
AB This study examined the relationship between general population characteristics and diet-related factors pertaining to eating alone for older adults (65 years and older) in Korea. This study used the Korea National Health and Nutrition Examination Survey (KNHANES), 2016-2020, and the target population was 7037 Koreans aged 65 years or older who participated in the nutritional survey and health interview. Eating alone variables were classified as follows. Eating together all day means "eating together", eating only one meal a day means "1/day", eating two meals a day alone means "2/day", and "3/day" means eating three meals a day alone. The main results are as follows. The rate of moderate or severe food insecurity was 3.41% in the "eating together" group to 7.86% in the "3/day" group, which was 4.45% higher in the "3/day" group. Fruit + vegetable intake among food intake lowered by about 35 g from 301.2 g in the "eating together" group to 266.2 g in the "3 day" group. In addition, as a result of analyzing the prevalence of depression using the PHQ-9 score, the "3/day" group had a 1.775 to 2.464 times higher risk of depression than the "eating together" group. Finally, EQ-5D variables and quality of life scores were significantly lowered from the "eating together" group to the "3/day" group. Overall, higher frequency of eating alone was associated with food safety, essential food intake, and quality of life. Based on these results, it is thought that a dietary life support program such as the eating together program is necessary to improve the quality of life of the older people who eat alone.
C1 [Kwon, Yongseok] Natl Inst Agr Sci, 166 Nongsaengmyeong Ro, Wonju 55365, South Korea.
   [Hong, Kyung Hee] Dongseo Univ, Dept Food Sci & Nutr, Busan 47011, South Korea.
   [Park, Yoo-Kyung; Kim, Sohye] Kyung Hee Univ, Grad Sch East West Med Sci, Dept Med Nutr, Yongin 17104, South Korea.
   [Kim, Sohye] Seoul Natl Univ, Nutr Care Serv, Bundang Hosp, Seongnam 13620, South Korea.
C3 National Institute of Agricultural Sciences; Dongseo University; Kyung
   Hee University; Seoul National University (SNU)
RP Kim, S (corresponding author), Kyung Hee Univ, Grad Sch East West Med Sci, Dept Med Nutr, Yongin 17104, South Korea.; Kim, S (corresponding author), Seoul Natl Univ, Nutr Care Serv, Bundang Hosp, Seongnam 13620, South Korea.
EM sohye76@daum.net
RI Kim, Hyo/AAQ-3152-2020; Park, Yoo Kyoung/F-1735-2013
OI Kim, Sohye/0000-0003-0880-3580; Park, Yoo Kyoung/0000-0002-8536-0835
FU agro-food based basic research of the Korea Rural Development
   Administration grant [PJ017251]
FX This research was funded by the agro-food based basic research of the
   Korea Rural Development Administration grant (Project No. PJ017251).
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NR 50
TC 3
Z9 3
U1 0
U2 5
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD APR 26
PY 2023
VL 15
IS 9
AR 2085
DI 10.3390/nu15092085
PG 18
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA G2IM4
UT WOS:000987457300001
PM 37432236
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Shi, ZM
   Stern, N
   Liu, JH
   Tuomilehto, J
   Kronfeld-Schor, N
   El-Osta, A
   Alberti, G
   Chai, ZL
   Bilu, C
   Einat, H
   Marcus, Y
   Zimmet, P
AF Shi, Zumin
   Stern, Naftali
   Liu, Jianghong
   Tuomilehto, Jaakko
   Kronfeld-Schor, Noga
   El-Osta, Assam
   Alberti, George
   Chai, Zhonglin
   Bilu, Carmel
   Einat, Haim
   Marcus, Yonit
   Zimmet, Paul
TI The circadian syndrome is a predictor for cognition impairment in
   middle-aged adults: Comparison with the metabolic syndrome
SO DIABETES-METABOLISM RESEARCH AND REVIEWS
LA English
DT Article
DE adults; Chinese; circadian syndrome; cognition; memory; metabolic
   syndrome; sleep
ID VASCULAR RISK-FACTORS; ALZHEIMERS-DISEASE; DEMENTIA; SLEEP; OBESITY;
   DEPRESSION; PREVALENCE; MIDLIFE; DECLINE; PERFORMANCE
AB Aims: Circadian syndrome (CircS) is considered a better predictor for cardiovascular disease than the metabolic syndrome (MetS). We aim to examine the associations between CircS and MetS with cognition in Chinese adults. Method: We used the data of 8546 Chinese adults aged >= 40 years from the 2011 China Health and Retirement Longitudinal Study. MetS was defined using harmonised criteria. CircS included the components of MetS plus short sleep and depression. The cut-off for CircS was set as >= 4. Global cognitive function was assessed during the face-to-face interview. Results: CircS and MetS had opposite associations with the global cognition score and self-reported poor memory. Compared with individuals without the CircS and MetS, the regression coefficients (95%CI) for global cognition score were -1.02 (-1.71 to -0.34) for CircS alone and 0.52 (0.09 to 0.96) for MetS alone in men; -1.36 (-2.00 to -0.72) for CircS alone and 0.60 (0.15 to 1.06) for MetS alone in women. Having CircS alone was 2.53 times more likely to report poor memory in men (95%CI 1.80-3.55) and 2.08 times more likely in women (95%CI 1.54-2.81). In contrast, having MetS alone was less likely to report poor memory (OR 0.64 (0.49-0.84) in men and 0.65 (0.52-0.81) in women). People with CircS and MetS combined were more likely to have self-reported poor memory. Conclusions: CircS is a strong and better predictor for cognition impairment than MetS in Chinese middle-aged adults. MetS without short sleep and depression is associated with better cognition.
C1 [Shi, Zumin] Qatar Univ, Coll Hlth Sci, Human Nutr Dept, QU Hlth, Doha 2713, Qatar.
   [Stern, Naftali; Marcus, Yonit; Zimmet, Paul] Tel Aviv Sourasky Med Ctr, Sagol Ctr Epigenet Aging & Metab, Tel Aviv, Israel.
   [Stern, Naftali; Marcus, Yonit] Tel Aviv Univ, Fac Med, Sagol Sch Neurosci, Tel Aviv, Israel.
   [Liu, Jianghong] Univ Penn, Sch Nursing, Philadelphia, PA USA.
   [Tuomilehto, Jaakko] Univ Helsinki, Dept Publ Hlth, Helsinki, Finland.
   [Tuomilehto, Jaakko] Finnish Inst Hlth & Welf, Populat Hlth Unit, Helsinki, Finland.
   [Tuomilehto, Jaakko] King Abdulaziz Univ, Saudi Diabet Res Grp, Jeddah, Saudi Arabia.
   [Kronfeld-Schor, Noga; Bilu, Carmel] Tel Aviv Univ, Sch Zool, Tel Aviv, Israel.
   [El-Osta, Assam; Chai, Zhonglin; Zimmet, Paul] Monash Univ, Sch Translat Med, Dept Diabet, Melbourne, Vic, Australia.
   [El-Osta, Assam] Baker Heart & Diabet Inst, Epigenet Human Hlth & Dis, Melbourne, Vic, Australia.
   [Alberti, George] Imperial Coll London, Dept Endocrinol & Metab, London, England.
   [Einat, Haim] Tel Aviv Yaffo Acad Coll, Sch Behav Sci, Tel Aviv, Israel.
C3 Qatar University; Tel Aviv University; Sackler Faculty of Medicine; Tel
   Aviv Sourasky Medical Center; Tel Aviv University; University of
   Pennsylvania; University of Helsinki; King Abdulaziz University; Tel
   Aviv University; Monash University; Imperial College London
RP Shi, ZM (corresponding author), Qatar Univ, Coll Hlth Sci, Human Nutr Dept, QU Hlth, Doha 2713, Qatar.
EM zumin@qu.edu.qa
RI Zimmet, Paul/H-7635-2013; Shi, Zumin/A-1093-2009; tuomilehto,
   jaakko/E-6504-2011; CHAI, ZHONGLIN/X-1342-2019; Kronfeld-Schor,
   Noga/AAU-3792-2020; Liu, Jianghong/AAE-8130-2020
OI Kronfeld-Schor, Noga/0000-0002-5224-3341; El-Osta,
   Assam/0000-0003-2969-9137; Shi, Zumin/0000-0002-3099-3299; Chai,
   Zhonglin/0000-0001-8182-8579
FU Qatar National Library
FX No Statement AvailableWe would like to acknowledge the CHARLS team for
   providing data and the training of using the dataset.Open Access funding
   was provided by the Qatar National Library.
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NR 60
TC 5
Z9 6
U1 10
U2 19
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1520-7552
EI 1520-7560
J9 DIABETES-METAB RES
JI Diabetes-Metab. Res. Rev.
PD JUL
PY 2024
VL 40
IS 5
AR e3827
DI 10.1002/dmrr.3827
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA TD0F3
UT WOS:001239198000001
PM 38837323
OA hybrid
DA 2025-06-11
ER

PT J
AU Itoh, H
   Muramatsu-Kato, K
   Ferdous, UJ
   Kohmura-Kobayashi, Y
   Kanayama, N
AF Itoh, Hiroaki
   Muramatsu-Kato, Keiko
   Ferdous, Urmi J.
   Kohmura-Kobayashi, Yukiko
   Kanayama, Naohiro
TI Undernourishment in utero and hepatic steatosis in later life: A
   potential issue in Japanese people
SO CONGENITAL ANOMALIES
LA English
DT Review
DE developmental origins of health and disease; low birthweight; metabolic
   syndrome; nonalcoholic fatty liver disease; pregnancy
ID ENDOPLASMIC-RETICULUM STRESS; FATTY LIVER-DISEASE; SUBSEQUENT OBESITY;
   METABOLIC SYNDROME; RISK-FACTORS; ADULT MICE; WEIGHT; UNDERNUTRITION;
   FAMINE; GROWTH
AB Nonalcoholic fatty liver disease (NAFLD) is a hepatic manifestation of metabolic syndrome. The prevalence of NAFLD in Japan has nearly doubled in the last 10-15 years. Increasing evidence supports undernourishment in utero being causatively connected with the risk of NAFLD in later life. Low body mass index (BMI) has been common among Japanese women of childbearing age for several decades due to their strong desire to be thin. It is plausible that insufficient maternal energy intake by pregnant Japanese women may underlie the rapid increase in the prevalence of NAFLD in Japan. In order to clarify the mechanisms by which undernourishment in utero primes adult hepatic steatosis, we developed a mouse model of fetal undernourishment with a hepatic fat deposit-prone phenotype on an obesogenic high fat diet in later life. We found that endoplasmic reticulum (ER) stress response parameters were activated concomitantly with the deterioration of hepatic steatosis and also that the alleviation of ER stress with the chemical chaperone, tauroursodeoxycholic acid (TUDCA), significantly improved hepatic steatosis. Therefore, undernourishment in utero may program the future integration of ER stress in the liver on an obesogenic diet in later life and also induce the deterioration of hepatic steatosis. These results also provide an insight into interventions for the potential high-risk population of NAFLD, such as those born small or exposed to maternal undernourishment during the fetal period, with the alleviation of ER stress by dietary supplements and/or specific food including chaperones.
C1 [Itoh, Hiroaki; Muramatsu-Kato, Keiko; Ferdous, Urmi J.; Kohmura-Kobayashi, Yukiko; Kanayama, Naohiro] Hamamatsu Univ, Sch Med, Dept Obstet & Gynecol, Hamamatsu, Shizuoka, Japan.
C3 Hamamatsu University School of Medicine
RP Itoh, H (corresponding author), Hamamatsu Univ, Sch Med, Dept Obstet & Gynecol, Higashi Ku, 1-20-1 Handayama, Hamamatsu, Shizuoka 4313192, Japan.
EM hitou-endo@umin.ac.jp
FU Ministry of Education, Science, Culture and Sports of Japan [15H04882,
   16K15703]; Grants-in-Aid for Scientific Research [15H04882, 16K15703,
   16K20185] Funding Source: KAKEN
FX The authors thank Mrs Nahoko Hakamata, Yumiko Yamamoto, Naoko Kondo,
   Miuta Sawai, and Kazuko Sugiyama for their secretarial or technical
   assistance. This work was supported in part by Grants-in-Aid for
   Scientific Research from the Ministry of Education, Science, Culture and
   Sports of Japan (Nos. 15H04882 and 16K15703).
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NR 41
TC 8
Z9 9
U1 0
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0914-3505
EI 1741-4520
J9 CONGENIT ANOM
JI Congenit. Anom.
PD NOV
PY 2017
VL 57
IS 6
BP 178
EP 183
DI 10.1111/cga.12200
PG 6
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA FL7XS
UT WOS:000414464800002
PM 27859643
OA Bronze
DA 2025-06-11
ER

PT J
AU Yan, HM
   Chen, SL
   Gao, XR
   Jiang, YH
   Liang, GY
   Peng, J
   Cai, SH
AF Yan, Haiming
   Chen, Suling
   Gao, Xinrui
   Jiang, Yuanhui
   Liang, Guangyu
   Peng, Jie
   Cai, Shaohang
TI Association Between TyG Index, Liver Steatosis and Immunosenescence in
   People Living with HIV
SO INFECTION AND DRUG RESISTANCE
LA English
DT Article
DE HIV/AIDS; triglyceride-glucose index; metabolic disorders;
   immunosenescence; hepatic steatosis
ID INSULIN-RESISTANCE; METABOLIC SYNDROME; DEPRESSION; INFLAMMATION;
   INFECTION
AB Background: Metabolic disorders and immunosenescence increase the risk of complications in people living with HIV (PLWH), affecting mortality and quality of life. However, their relationship remains unclear. Methods: Participants were grouped by median TyG index, and logistic regression identified baseline independent factors of a high TyG index at Week 24. The association of the TyG index for hepatic steatosis was determined using ROC curves. We also explored correlations between the TyG index and aging markers, including CD4/CD8 ratio and CD8+ T cells and evaluated health-related quality of life (HRQoL). Results: A total of 203 PLWH were included in the study. We observed that PLWH in high TyG group tended to be older (P<0.001), have greater body weight (P<0.001), higher ALT levels (P=0.021), and increased low-density lipoprotein levels (P=0.001). ROC analysis revealed that TyG index was closely associated with hepatic steatosis at Week 52 (AUC=0.743) and Week 104 (AUC=0.728). Moreover, a higher TyG index was positively correlated with CD8+ T cell counts, while patients in the high TyG group had lower CD4/CD8 ratios at Week 52 and Week 104. Poorer mental health was observed in patients with CD8+ T cell counts >= 1000 and a high TyG index. Multivariate analysis further identified baseline older age (OR=1.108, P=0.002), elevated cholesterol (OR=3.407, P<0.001), and low HDL (OR=0.003, P<0.001) as factors associated with a high TyG index at Week 24. Conclusion: The TyG index is closely linked to metabolic disorders and immunosenescence in PLWH. It offers a basis for personalized treatment strategies, improving physical and mental health and reducing complication risks.
C1 [Yan, Haiming; Chen, Suling; Gao, Xinrui; Jiang, Yuanhui; Liang, Guangyu; Peng, Jie; Cai, Shaohang] Southern Med Univ, Nanfang Hosp, Dept Infect Dis, Guangzhou 510515, Peoples R China.
   [Yan, Haiming; Chen, Suling; Gao, Xinrui; Jiang, Yuanhui; Liang, Guangyu; Peng, Jie; Cai, Shaohang] Guangdong Inst Hepatol, Minist Educ, Guangdong Prov Clin Res Ctr Viral Hepatitis, Key Lab Infect Dis Res South China,Guangdong Prov, Guangzhou, Peoples R China.
   [Chen, Suling] First Peoples Hosp Foshan, Dept Infect Dis, Foshan, Peoples R China.
C3 Southern Medical University - China; Ministry of Education - China
RP Peng, J; Cai, SH (corresponding author), Southern Med Univ, Nanfang Hosp, Dept Infect Dis, Guangzhou 510515, Peoples R China.
EM pjie138@163.com; shaohangcai@foxmail.com
RI XR, Gao/KRQ-3011-2024
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NR 50
TC 2
Z9 2
U1 1
U2 2
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-6973
J9 INFECT DRUG RESIST
JI Infect. Drug Resistance
PY 2024
VL 17
BP 5049
EP 5059
DI 10.2147/IDR.S493140
PG 11
WC Infectious Diseases; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases; Pharmacology & Pharmacy
GA M3O4F
UT WOS:001356667700001
PM 39559341
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Yamaguchi, Y
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   Yoshikawa, N
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AF Yamaguchi, Yu
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   Nakamura, Kazuki
   Haginaka, Jun
   Kunitomo, Masaru
TI Corosolic acid prevents oxidative stress, inflammation and hypertension
   in SHR/NDmcr-cp rats, a model of metabolic syndrome
SO LIFE SCIENCES
LA English
DT Article
DE corosolic acid; metabolic syndrome; model rats; oxidative stress
ID LOW-DENSITY-LIPOPROTEIN; ENDOTHELIAL DYSFUNCTION; SUPEROXIDE-DISMUTASE;
   INSULIN-RESISTANCE; AQUEOUS EXTRACTS; BLOOD-PRESSURE; DNA-DAMAGE;
   PEROXYNITRITE; PROTEIN; ROLES
AB Corosolic acid (CRA), a constituent of banaba leaves, has been reported to have anti-inflammatory and hypoglycemic activities. The aim of this study was to determine the effects of CRA on metabolic risk factors including obesity, hypertension, hyperinsulinemia, hyperglycemia, and hyperlipidemia together with oxidative stress and inflammation, all of which are characteristic of the SHR/NDmcr-cp (cp/cp) (SHR-cp) rat, an animal model of metabolic syndrome. Six-week-old male SHR-cp rats were fed a high fat diet containing 0.072% CRA for 14 weeks. Treatment with CRA lowered blood pressure, which was elevated in control animals, by 10% after 8 weeks, and serum free fatty acids by 2 1 % after 2 weeks. CRA treatment resulted in decreases in the levels of the oxidative stress markers thiobarbituric acid-reactive substances and 8-hydroxydeoxyguanosine by 27% and 59%, respectively, after 2 weeks. CRA treatment also reduced the levels of myeloperoxidase markers, 3-nitrotyrosine and 3-chlorotyrosine by 38% and 39%, respectively, after 10 weeks, and tended to decrease the levels of high sensitivity C-reactive protein, a marker of inflammation, after 6 weeks. However, CRA had no effect on weight gain or hyperglycemia. These results demonstrate that CRA can ameliorate hypertension, abnormal lipid metabolism, and oxidative stress as well as the inflammatory state in SHR-cp rats. This implies that MA can be beneficial for preventing atherosclerosis-related diseases that are an increasing health care problem worldwide. (c) 2006 Elsevier Inc. All rights reserved.
C1 Mukogawa Womens Univ, Sch Pharm & Pharmaceut Sci, Dept Pharmacol, Nishinomiya, Hyogo 6638179, Japan.
   Use Techno Corp Co Ltd, Kyoto, Japan.
   Mukogawa Womens Univ, Sch Pharm & Pharmaceut Sci, Dept Analyt Chem, Nishinomiya, Hyogo 6638179, Japan.
C3 Mukogawa Women's University; Mukogawa Women's University
RP Yamaguchi, Y (corresponding author), Mukogawa Womens Univ, Sch Pharm & Pharmaceut Sci, Dept Pharmacol, 11-68 Koshien Kyuban Cho, Nishinomiya, Hyogo 6638179, Japan.
EM yusan@mukogawa-u.ac.jp
RI Haginaka, Jun/K-5672-2012
OI Haginaka, Jun/0000-0001-6760-7745
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NR 42
TC 106
Z9 116
U1 5
U2 18
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0024-3205
EI 1879-0631
J9 LIFE SCI
JI Life Sci.
PD NOV 25
PY 2006
VL 79
IS 26
BP 2474
EP 2479
DI 10.1016/j.lfs.2006.08.007
PG 6
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA 112ZB
UT WOS:000242565600007
PM 16959274
DA 2025-06-11
ER

PT J
AU Kelishadi, R
   Sharifi, M
   Khosravi, A
   Adeli, K
AF Kelishadi, Roya
   Sharifi, Mohsen
   Khosravi, Alireza
   Adeli, Khosrow
TI Relationship between C-reactive protein and atherosclerotic risk factors
   and oxidative stress markers among young persons 10-18 years old
SO CLINICAL CHEMISTRY
LA English
DT Article
ID INSULIN-RESISTANCE ATHEROSCLEROSIS; LIPID-PEROXIDATION PRODUCTS;
   CORONARY-HEART-DISEASE; METABOLIC SYNDROME; JAPANESE POPULATION; OBESE
   CHILDREN; ADOLESCENTS; INFLAMMATION; ASSOCIATION; YOUTH
AB Background: This study was undertaken to determine the association of serum C-reactive protein (CRP) with generalized and abdominal obesity, body fat composition, the metabolic syndrome, and oxidative stress markers among young people.
   Methods: We conducted a population-based study of 512 young people, aged 10-18 years. We obtained anthropometric and blood pressure measurements. Fasting blood sugar, total cholesterol (TC), HDL-cholesterol, triglycerides, CRP, malondialdehyde (MDA), and conjugated diene (CDE) were quantified. LDL-cholesterol (LDL-C) was calculated for samples with TG <= 4.52 mmol/L
   Results: Mean triglycerides, waist and hip circumferences, percentage body fat, subcutaneous fat, and systolic blood pressure increased significantly with increasing body mass index (BMI). In contrast, the mean LDL and TC were higher in underweight than normal weight individuals, and then increased significantly from normal to higher BMI categories. Mean HDL cholesterol significantly decreased with increasing BMI. Overall, CRP, MDA, and CDE were significantly correlated with measures of abdominal obesity. Serum CRP, MDA, and CDE significantly increased in the upper quartiles of waist circumference. Study participants with higher CRP concentrations were more likely to have metabolic syndrome and high oxidative stress markers.
   Conclusion: We found a significant positive association between CRP and oxidative stress markers in healthy young people, as well as an increase in these markers in the upper quartiles of waist circumference, but not BMI. Oxidative stress and CRP may interact in the early inflammatory processes of atherosclerosis. (c) 2007 American Association for Clinical Chemistry.
C1 Isfahan Univ Med Sci, Isfahan Cardiovasc Res Ctr, Prevent Pediat Cardiol Dept, Esfahan, Iran.
   Isfahan Univ Med Sci, Esfahan, Iran.
   Univ Toronto, Hosp Sick Children, Toronto, ON, Canada.
C3 Isfahan University of Medical Sciences; Isfahan University of Medical
   Sciences; University of Toronto; Hospital for Sick Children (SickKids)
RP Kelishadi, R (corresponding author), Isfahan Univ Med Sci, Isfahan Cardiovasc Res Ctr, Prevent Pediat Cardiol Dept, POB 81465-1148, Esfahan, Iran.
EM kroya@aap.net
RI ; Kelishadi, Roya/E-6154-2012; Khosravi Farsani, Alireza/B-7453-2018
OI Adeli, Khosrow/0000-0002-5839-5709; Kelishadi, Roya/0000-0001-7455-1495;
   Khosravi Farsani, Alireza/0000-0003-0736-2090
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NR 39
TC 56
Z9 60
U1 0
U2 6
PU AMER ASSOC CLINICAL CHEMISTRY
PI WASHINGTON
PA 2101 L STREET NW, SUITE 202, WASHINGTON, DC 20037-1526 USA
SN 0009-9147
J9 CLIN CHEM
JI Clin. Chem.
PD MAR
PY 2007
VL 53
IS 3
BP 456
EP 464
DI 10.1373/clinchem.2006.073668
PG 9
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA 141BC
UT WOS:000244550300012
PM 17259238
OA Bronze
DA 2025-06-11
ER

PT J
AU Saeed, M
   Naveed, M
   BiBi, J
   Ali Kamboh, A
   Phil, L
   Chao, S
AF Saeed, Muhammad
   Naveed, Muhammad
   BiBi, Jannat
   Ali Kamboh, Asghar
   Phil, Lucas
   Chao, Sun
TI Potential nutraceutical and food additive properties and risks of
   coffee: a comprehensive overview
SO CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
LA English
DT Review
DE Phenolic compounds; caffeine; diterpenes; metabolic syndrome; mental
   health; liver disease; antioxidant; antimicrobial; modulators; risk
   factors; pregnancy; cigarette smoking
ID GAMMA-GLUTAMYL-TRANSFERASE; CORONARY-HEART-DISEASE; LOW-BIRTH-WEIGHT;
   IMPAIRED GLUCOSE-TOLERANCE; CHOLESTEROL-RAISING FACTOR; PLASMA TOTAL
   HOMOCYSTEINE; ACTIVATED PROTEIN-KINASE; ALL-CAUSE MORTALITY; CHLOROGENIC
   ACID; CAFFEINE CONSUMPTION
AB Coffee is a composite mixture of more than a thousand diverse phytochemicals like alkaloids, phenolic compounds, vitamins, carbohydrates, lipids, minerals and nitrogenous compounds. Coffee has multifunctional properties as a food additive and nutraceutical. As a nutraceutical, coffee has anti-inflammatory, anti-oxidant, antidyslipidemic, anti-obesity, type-2 diabetes mellitus (DM), and cardiovascular diseases (CVD), which can serve for the treatment and prevention of metabolic syndrome and associated disorders. On the other hand, as a food additive, coffee has antimicrobial activity against a wide range of microorganisms, inhibits lipid peroxidation (LPO), and can function as a prebiotic. The outcomes of different studies also revealed that coffee intake may reduce the incidence of numerous chronic diseases, like liver disease, mental health, and it also overcomes the all-cause mortality, and suicidal risks. In some studies, high intake of coffee is linked to increase CVD risk factors, like cholesterol, plasma homocysteine and blood pressure (BP). There is also a little evidence that associated the coffee consumption with increased risk of lung tumors in smokers. Among adults who consume the moderate amount of coffee, there is slight indication of health hazards with strong indicators of health benefits. Moreover, existing literature suggests that it may be cautious for pregnant women to eliminate the chances of miscarriages and impaired fetal growth. The primary purpose of this narrative review is to provide an overview of the findings of the positive impacts and risks of coffee consumption on human health. In conclusion, to date, the best available evidence from research indicates that drinking coffee up to 3-4 cups/day provides health benefits for most people.
C1 [Saeed, Muhammad; Chao, Sun] Northwest A&F Univ, Coll Anim Sci & Technol, Dept Anim Nutr, Yangling 71200, Shaanxi, Peoples R China.
   [Naveed, Muhammad] Nanjing Med Univ, Sch Pharm, Dept Clin Pharmacol, Nanjing, Jiangsu, Peoples R China.
   [BiBi, Jannat] Shaanxi Normal Univ, Dept Phys Educ, Xian, Shaanxi, Peoples R China.
   [Ali Kamboh, Asghar] Sindh Agr Univ, Fac Anim Husb & Vet Sci, Dept Vet Microbiol, Tandojam, Sindh Province, Pakistan.
   [Phil, Lucas] China Pharmaceut Univ, Sch Pharm, Dept Pharmaceut Anal, Nanjing, Jiangsu, Peoples R China.
C3 Northwest A&F University - China; Nanjing Medical University; Shaanxi
   Normal University; Sindh Agricultural University; China Pharmaceutical
   University
RP Chao, S (corresponding author), Northwest A&F Univ, Coll Anim Sci & Technol, Dept Anim Nutr, Yangling 71200, Shaanxi, Peoples R China.
EM sunchao2775@163.com
RI Kamboh, Asghar/AAA-2099-2020; Naveed, Muhammad/Y-3856-2018; PHIL,
   LUCAS/IRZ-1617-2023; Bibi, Jannat/AAB-3363-2020; Saeed,
   Muhammad/D-1844-2017
OI Sun, Chao/0000-0001-7222-4028; Saeed, Muhammad/0000-0001-5048-5753;
   Bibi, Jannat/0000-0002-6710-5216; Kamboh, Asghar/0000-0002-5176-6685
FU National Nature Science Foundation of China [31572365, 2017KCT-24];
   Major National Scientific Research Projects [2015CB943102]
FX This work was supported by National Nature Science Foundation of China
   [31572365 & 2017KCT-24], and Major National Scientific Research Projects
   [#. 2015CB943102] P.R China. We are highly thankful to Mr. Muhammad
   Karim Ahmed from CRI for critically reviewing the text of this paper.
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NR 345
TC 33
Z9 35
U1 4
U2 80
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1040-8398
EI 1549-7852
J9 CRIT REV FOOD SCI
JI Crit. Rev. Food Sci. Nutr.
PD NOV 13
PY 2019
VL 59
IS 20
BP 3293
EP 3319
DI 10.1080/10408398.2018.1489368
PG 27
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Food Science & Technology; Nutrition & Dietetics
GA JN0WC
UT WOS:000496624400004
PM 30614268
DA 2025-06-11
ER

PT J
AU Crocco, M
   d'Annunzio, G
   La Valle, A
   Piccolo, G
   Chiarenza, DS
   Bigatti, C
   Molteni, M
   Milanaccio, C
   Garre, ML
   Di Iorgi, N
   Maghnie, M
AF Crocco, Marco
   d'Annunzio, Giuseppe
   La Valle, Alberto
   Piccolo, Gianluca
   Chiarenza, Decimo Silvio
   Bigatti, Carolina
   Molteni, Marta
   Milanaccio, Claudia
   Garre, Maria Luisa
   Di Iorgi, Natascia
   Maghnie, Mohamad
TI Endothelial Dysfunction in Childhood Cancer Survivors: A Narrative
   Review
SO LIFE-BASEL
LA English
DT Article
DE cancer survivors; endothelial dysfunction; noncommunicable diseases
   prevention; flow mediated dilation; carotid intima media thickness;
   peripheral artery tonometry; pulse wave velocity; atherosclerosis;
   vascular toxicity; cardiotoxicity
ID PULSE-WAVE VELOCITY; INTIMA-MEDIA THICKNESS; LONG-TERM SURVIVORS;
   PERIPHERAL ARTERIAL TONOMETRY; ACUTE LYMPHOBLASTIC-LEUKEMIA; ADOLESCENTS
   REFERENCE VALUES; CARDIOVASCULAR RISK-FACTORS; AMBULATORY
   BLOOD-PRESSURE; METABOLIC SYNDROME; HEALTHY-CHILDREN
AB Assessment of endothelial dysfunction in cancer survivors may have a role in the early identification of non-communicable diseases and cardiovascular late effects. Oncological therapies may impair endothelial function. Therefore, in patients such as childhood cancer survivors who could benefit from early cardioprotective pharmacological interventions, it is essential to monitor endothelial function, even if the optimal methodology for investigating the multifaceted aspects of endothelial dysfunction is still under debate. Biochemical markers, as well as invasive and non-invasive tools with and without pharmacological stimuli have been studied. Human clinical studies that have examined lifestyle or cancer treatment protocols have yielded evidence showing the involvement of lipid and lipoprotein levels, glycemic control, blood pressure, adiposity, inflammation, and oxidative stress markers on the state of endothelial health and its role as an early indicator of cardiometabolic risk. However, with regards to pharmacological interventions, cautious interpretation of the result attained whilst monitoring the endothelial function is warranted due to methodological limitations and substantial heterogeneity of the results reported in the published studies. In this narrative review, an overview of evidence from human clinical trials examining the effects of cancer therapies on endothelial disease is provided together with a discussion of endothelial function assessment using the different non-invasive techniques available for researchers and clinicians, in recent years.
C1 [Crocco, Marco; Piccolo, Gianluca; Milanaccio, Claudia; Garre, Maria Luisa] Ist Ricovero & Cura Carattere Sci, Neurooncol Unit, Giannina Gaslini Inst, I-16147 Genoa, Italy.
   [Crocco, Marco; La Valle, Alberto; Piccolo, Gianluca; Chiarenza, Decimo Silvio; Bigatti, Carolina; Molteni, Marta; Di Iorgi, Natascia; Maghnie, Mohamad] Univ Genoa, Dept Neurosci Rehabil Ophthalmol Genet Child & Ma, I-16100 Genoa, Italy.
   [d'Annunzio, Giuseppe; Di Iorgi, Natascia; Maghnie, Mohamad] Ist Ricovero & Cura Carattere Sci, Dept Pediat, Giannina Gaslini Inst, I-16147 Genoa, Italy.
C3 University of Genoa; IRCCS Istituto Giannina Gaslini; University of
   Genoa; University of Genoa; IRCCS Istituto Giannina Gaslini
RP Crocco, M (corresponding author), Ist Ricovero & Cura Carattere Sci, Neurooncol Unit, Giannina Gaslini Inst, I-16147 Genoa, Italy.; Crocco, M (corresponding author), Univ Genoa, Dept Neurosci Rehabil Ophthalmol Genet Child & Ma, I-16100 Genoa, Italy.
EM marcocrocco@gaslini.org; giuseppedannunzio@gaslini.org;
   albertolavalle88@gmail.com; giangi.piccolo@gmail.com;
   silvio.chiarenza@yahoo.com; carolina.bigatti.cb@gmail.com;
   marta.molteni.1991@gmail.com; Claudiamilanaccio@gaslini.org;
   mluisagarre@gaslini.org; natasciadiiorgi@gaslini.org;
   mohamadmaghnie@gaslini.org
RI Maghnie, Marwa/AAE-5311-2022; Piccolo, Gianluca/AAO-4510-2021; Garrè,
   Maria/K-4205-2018; Di Iorgi, Natascia/AAB-8486-2021; d'Annunzio,
   Giuseppe/J-7368-2018; Crocco, Marco/AAC-2498-2019
OI Piccolo, Gianluca/0000-0003-2815-6288; Crocco,
   Marco/0000-0001-7277-4767; Chiarenza, Decimo Silvio/0000-0002-6877-9511;
   d'Annunzio, Giuseppe/0000-0002-1856-2277; MAGHNIE,
   Mohamad/0000-0002-7183-5238
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NR 105
TC 4
Z9 4
U1 0
U2 2
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2075-1729
J9 LIFE-BASEL
JI Life-Basel
PD JAN
PY 2022
VL 12
IS 1
AR 45
DI 10.3390/life12010045
PG 34
WC Biology; Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics; Microbiology
GA YL8MK
UT WOS:000746141400001
PM 35054438
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Villeda-González, JD
   Gómez-Olivares, JL
   Baiza-Gutman, LA
   Manuel-Apolinar, L
   Damasio-Santana, L
   Millán-Pacheco, C
   Angeles-Mejía, S
   Cortés-Ginez, MC
   Cruz-López, M
   Vidal-Moreno, CJ
   Díaz-Flores, M
AF Villeda-Gonzalez, J. D.
   Gomez-Olivares, J. L.
   Baiza-Gutman, L. A.
   Manuel-Apolinar, L.
   Damasio-Santana, L.
   Millan-Pacheco, C.
   Angeles-Mejia, S.
   Cortes-Ginez, M. C.
   Cruz-Lopez, M.
   Vidal-Moreno, C. J.
   Diaz-Flores, M.
TI Nicotinamide reduces inflammation and oxidative stress via the
   cholinergic system in fructose-induced metabolic syndrome in rats
SO LIFE SCIENCES
LA English
DT Article
DE Metabolic syndrome; Acetylcholinesterase; Butyrylcholinesterase;
   Nicotinamide; Fructose
ID CARDIOVASCULAR-DISEASE; SOFTWARE NEWS; RISK-FACTORS;
   BUTYRYLCHOLINESTERASE; ACETYLCHOLINESTERASE; ASSOCIATION; CHARMM
AB Aims: Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) have been associated with risk factors for metabolic syndrome (MetS). Our objective was to evaluate the effect of nicotinamide (NAM) on the activities, expression and protein content of cholinesterases in a MetS model.
   Main methods: MetS was induced in male rats administrating 40% fructose to the drinking water for 16 weeks. Additionally, from 5th week onward, the carbohydrate solution was replaced by NAM, at several concentrations for 5 h each morning for the next 12 weeks. In the 15th week, the glucose tolerance test was conducted, and blood pressure was measured. After the treatment period had concluded, the biochemical profile; oxidant stress; proinflammatory markers; and the activity, quantity and expression of cholinesterases were evaluated, and molecular docking analysis was performed.
   Key findings: The MetS group showed anthropometric, hemodynamic and biochemical alterations and increased cholinesterase activity, inflammation and stress markers. In the liver, cholinesterase activity and mRNA, free fatty acid, tumor necrosis factor-alpha (TNF-alpha), and thiobarbituric acid-reactive substance (TBARS) levels were increased, while reduced glutathione (GSH) levels were decreased. NAM partially or totally decreased risk factors for MetS, markers of stress and inflammation, and the activity (serum and liver) and expression (liver) of cholinesterases. Molecular docking analysis showed that NAM has a greater affinity for cholinesterases than acetylcholine (ACh), suggesting NAM as an inhibitor of cholinesterases.
   Significance: Supplementation with 40% fructose induced MetS, which increased the activity and expression of cholinesterases, oxidative stress and the inflammation. NAM attenuated these MetS-induced alterations and changes in cholinesterases.
C1 [Villeda-Gonzalez, J. D.] Univ Autonoma Metropolitana Iztapalapa, Programa Posgrado Biol Expt, San Rafael Atlixco 186, Mexico City, DF, Mexico.
   [Villeda-Gonzalez, J. D.; Cortes-Ginez, M. C.; Cruz-Lopez, M.; Diaz-Flores, M.] Inst Mexicano Seguro Social, Ctr Med Nacl Siglo 21, Hosp Especialidades Bernardo Sepulveda Gutierrez, Unidad Invest Med Bioquim, 1Er Piso,Ave Cuauhtemoc 330, Mexico City 06725, DF, Mexico.
   [Gomez-Olivares, J. L.] Univ Autonoma Metropolitana Iztapalapa, Lab Biomembranas, Div Ciencias Biol & Salud, San Rafael Atlixco 186, Mexico City, DF, Mexico.
   [Baiza-Gutman, L. A.; Angeles-Mejia, S.] Univ Nacl Autonoma Mexico, Fac Estudios Super Iztacala, Unidad Morfol & Func, Lab Biol Desarrollo, Mexico City, Estado De Mexic, Mexico.
   [Manuel-Apolinar, L.; Damasio-Santana, L.] Inst Mexicano Seguro Social, Ctr Med Nacl Siglo 21, Hosp Especialidades Bernardo Sepulveda Gutierrez, Unidad Invest Med Enfermedades Endocrinas, Mexico City, DF, Mexico.
   [Millan-Pacheco, C.] Univ Autonoma Estado Morelos, Fac Farm, Cuernavaca, Morelos, Mexico.
   [Vidal-Moreno, C. J.] Univ Murcia, Dept Bioquim & Biol Mol A, Reg Campus Int Excellence Campus Mare Nostrum, Murcia, Spain.
C3 Universidad Autonoma Metropolitana - Mexico; Instituto Mexicano del
   Seguro Social; Universidad Autonoma Metropolitana - Mexico; Universidad
   Nacional Autonoma de Mexico; Instituto Mexicano del Seguro Social;
   Universidad Autonoma del Estado de Morelos; University of Murcia
RP Díaz-Flores, M (corresponding author), Inst Mexicano Seguro Social, Ctr Med Nacl Siglo 21, Hosp Especialidades Bernardo Sepulveda Gutierrez, Unidad Invest Med Bioquim, 1Er Piso,Ave Cuauhtemoc 330, Mexico City 06725, DF, Mexico.
EM mardiaz2001@yahoo.com
RI Manuel, Leticia/ABC-7215-2020; Villeda-González, Juan
   David/ITV-3995-2023; Baiza-Gutman, Luis/H-9160-2019; /Y-6604-2018;
   Millan-Pacheco, Cesar/I-4030-2016; Cruz Lopez, Miguel/O-5493-2018
OI Villeda Gonzalez, Juan David/0000-0002-5279-8590; /0000-0002-5663-4710;
   Millan-Pacheco, Cesar/0000-0001-5180-6504; Angeles Mejia,
   Selene/0000-0002-5530-5712; Baiza-Gutman, Luis
   Arturo/0000-0002-3669-4185; Cruz Lopez, Miguel/0000-0001-9985-6172
FU Fondo de Investigacion en Salud, Instituto Mexicano del Seguro Social
   [FIS/IMSS/PROT/GH-2/1738]; CONACyT [570363, CVU 634838]
FX The research was funded by Fondo de Investigacion en Salud, Instituto
   Mexicano del Seguro Social (FIS/IMSS/PROT/GH-2/1738). And to CONACyT for
   granting me the scholarship with registration number 570363 and No. CVU
   634838.
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NR 50
TC 19
Z9 19
U1 2
U2 13
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0024-3205
EI 1879-0631
J9 LIFE SCI
JI Life Sci.
PD JUN 1
PY 2020
VL 250
AR 117585
DI 10.1016/j.lfs.2020.117585
PG 11
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA LK2SC
UT WOS:000530710200014
PM 32243928
DA 2025-06-11
ER

PT J
AU Geetha, R
   Priya, CS
   Anuradha, CV
AF Geetha, Rajagopalan
   Priya, Chandrasekaran Sathiya
   Anuradha, Carani Venkatraman
TI Troxerutin abrogates mitochondrial oxidative stress and myocardial
   apoptosis in mice fed calorie-rich diet
SO CHEMICO-BIOLOGICAL INTERACTIONS
LA English
DT Article
DE High-fat-high fructose diet; Metabolic syndrome; Oxidative stress;
   Apoptosis; Troxerutin
ID HIGH-FAT; INSULIN-RESISTANCE; METABOLIC SYNDROME; HIGH-CARBOHYDRATE;
   CELL-DEATH; FED RATS; HEART; CARDIOLIPIN; MUSCLE; DYSFUNCTION
AB Mitochondrial oxidative stress plays a major role in the pathogenesis of myocardial apoptosis in metabolic syndrome (MS) patients. In this study, we investigated the effect of troxerutin (TX), an antioxidant on mitochondrial oxidative stress and apoptotic markers in heart of mice fed fat and fructose-rich diet. Adult male Mus musculus mice were fed either control diet or high fat, high fructose diet (HFFD) for 60 days to induce MS. Mice from each dietary group were divided into two on the 16th day and were either treated or untreated with TX (150 mg/kg bw, p.o) for the next 45 days. At the end of the study, mitochondrial reactive oxygen species (ROS) generation, oxidative stress markers, levels of intracellular calcium, cardiolipin content, cytochrome c release and apoptotic markers were examined in the myocardium. HFFD-feeding resulted in diminution of antioxidants and increased ROS production, lipid peroxidation and oxidatively modified adducts of 8-OHG, 4-HNE and 3-NT. Further increase in Ca2+ thorn levels, low levels of calcium transporters and decrease in cardiolipin content were noted. Changes in the mitochondrial structure were observed by electron microscopy. Furthermore, cytochrome c release, increase in proapoptotic proteins (APAF-1, BAX, caspases-9 and-3) and decrease in antiapoptotic protein (BCL-2) in HFFD-fed mice suggest myocardial apoptosis. These changes were significantly restored by TX supplementation. TX administration effectively attenuated cardiac apoptosis and exerted a protective role by increasing antioxidant potential and by improving mitochondrial function. Thus, TX could be a promising therapeutic candidate for treating cardiac disease in MS patients. (C) 2017 Elsevier B.V. All rights reserved.
C1 [Geetha, Rajagopalan; Priya, Chandrasekaran Sathiya; Anuradha, Carani Venkatraman] Annamalai Univ, Dept Biochem & Biotechnol, Annamalainagar 608002, Tamil Nadu, India.
C3 Annamalai University
RP Anuradha, CV (corresponding author), Annamalai Univ, Dept Biochem & Biotechnol, Annamalainagar 608002, Tamil Nadu, India.
EM cvaradha@yahoo.com
RI Venkatraman, Anuradha/U-8717-2019; Chandrasekaran, Sathiya
   Priya/H-3718-2018
OI Carani Venkatraman, Anuradha/0000-0001-9924-2533; Chandrasekaran,
   Sathiya Priya/0000-0002-1943-1244
FU Indian Council of Medical Research (ICMR), New Delhi
   [3/1/2/(5)/OBS/2012/NCD-II]
FX The first author Rajagopalan Geetha received Senior Research Fellowship
   (SRF) from the Indian Council of Medical Research (ICMR), New Delhi
   (3/1/2/(5)/OBS/2012/NCD-II) to carry out this study.
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NR 47
TC 22
Z9 23
U1 0
U2 5
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0009-2797
EI 1872-7786
J9 CHEM-BIOL INTERACT
JI Chem.-Biol. Interact.
PD DEC 25
PY 2017
VL 278
BP 74
EP 83
DI 10.1016/j.cbi.2017.09.012
PG 10
WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology
GA FQ4BG
UT WOS:000418302000010
PM 28916335
DA 2025-06-11
ER

PT J
AU Brito-Monzani, JD
   Stoyell-Conti, FF
   Shecaira, TP
   Silva, MPDF
   Dias, DD
   Bernardes, N
   De Angelis, K
AF Brito-Monzani, Janaina de Oliveira
   Stoyell-Conti, Filipe Fernandes
   Shecaira, Tania Plens
   Silva, Michel Pablo dos Santos Ferreira
   Dias, Danielle da Silva
   Bernardes, Nathalia
   De Angelis, Katia
TI Aerobic or resistance training improves autonomic control of circulation
   in oophorectomized rats with cardiometabolic dysfunctions: Impact on
   renal oxidative stress
SO EXPERIMENTAL GERONTOLOGY
LA English
DT Article
DE Exercise training; Oophorectomy; Kidney; Oxidative stress; Baroreflex
   sensitivity
ID METABOLIC SYNDROME; BAROREFLEX SENSITIVITY; GENDER-DIFFERENCES; FATTY
   LIVER; EXERCISE; MENOPAUSE; HYPERTENSION; KIDNEY; MODEL; MORTALITY
AB Cardiovascular autonomic dysfunction is associated with end organ damage and increased risk of mortality. Menopause and metabolic syndrome increase the risk for cardiorenal complications. In this study, we investigated the effects of aerobic or resistance exercise training on autonomic control of circulation and renal oxidative stress in a model of menopause and metabolic syndrome. Female Wistar rats and spontaneously hypertensive rats (SHR) were divided into 5 groups (n = 8): control (C), hypertensive (H), and sedentary (FHO), aerobic trained (FHOTa) and resistance trained (FHOTr) oophorectomized hypertensive treated with fructose (100 mg/mL drink water for 19 weeks). The FHO group presented increased vascular sympathetic modulation (LF-SBP), impaired baroreflex sensitivity (BRS) associated with increased blood pressure (BP) when compared to the H group. Aerobic exercise training enhanced tachycardic responses, while resistance training improved bradycardic responses to BP changes, thus ameliorating BRS. Moreover, despite unchanged BP, both exercise training protocols were effective in preventing increase in LF-SBP, reduction in systemic nitric oxide bioavailability (NOx), and increase in oxidative stress in the renal tissue, by decreasing lipid and protein oxidation in renal tissue. Positive correlation between LF-SBP and renal lipoperoxidation (r = 0.63, p < 0.05), as well as a negative correlation between NOx and renal lipoperoxidation (r = -0.66, p < 0.05) were observed. In conclusion, both aerobic and resistance exercise training were effective in improving autonomic control of circulation and reducing renal oxidative stress, thus attenuating the deleterious effects induced by arterial hypertension and fructose overload in female rats after ovarian hormone deprivation.
C1 [Brito-Monzani, Janaina de Oliveira; Stoyell-Conti, Filipe Fernandes; Shecaira, Tania Plens; Silva, Michel Pablo dos Santos Ferreira; Dias, Danielle da Silva; Bernardes, Nathalia; De Angelis, Katia] Univ Nove Julho UNINOVE, Lab Translat Physiol, Sao Paulo, Brazil.
   [Brito-Monzani, Janaina de Oliveira] Fed Univ Maranhao UFMA, Sao Luis, Maranhao, Brazil.
   [Stoyell-Conti, Filipe Fernandes] Univ Miami, Dept Surg, Miami, FL USA.
   [Shecaira, Tania Plens; Dias, Danielle da Silva; De Angelis, Katia] Fed Univ Sao Paulo UNIFESP, Dept Physiol, Rua Botucatu,862,Edificio Ciencias Biomed,5 Andar, BR-04023062 Sao Paulo, SP, Brazil.
   [Bernardes, Nathalia] Sao Judas Tadeu Univ USJT, Human Movement Lab, Sao Paulo, SP, Brazil.
C3 Universidade Nove de Julho; Universidade Federal do Maranhao; University
   of Miami; Universidade Federal de Sao Paulo (UNIFESP); Universidade Sao
   Judas Tadeu
RP De Angelis, K (corresponding author), Fed Univ Sao Paulo UNIFESP, Dept Physiol, Rua Botucatu,862,Edificio Ciencias Biomed,5 Andar, BR-04023062 Sao Paulo, SP, Brazil.
EM prof.kangelis@yahoo.com.br
RI Bernardes, Nathalia/L-7460-2015; da Silva Dias, Danielle/AAN-7618-2020;
   DE ANGELIS, KATIA/I-6098-2016
FU Fundacao de Amparo e Pesquisa do Estado de Sao Paulo [FAPESP:
   2010/17188-4, 2012/20141-5, 2018/17183-4]; Conselho Nacional de
   Desenvolvimento Cientifico e Tecnologico (CNPq); Coordenacao
   Aperfeicoamento de Pessoal de Nivel Superior (CAPES-PROSUP); CNPq-BPQ
   fellowships
FX This study was supported by the Fundacao de Amparo e Pesquisa do Estado
   de Sao Paulo (FAPESP: 2010/17188-4; 2012/20141-5; 2018/17183-4) and
   Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) and
   Coordenacao Aperfeicoamento de Pessoal de Nivel Superior (CAPES-PROSUP).
   KDA is recipients of CNPq-BPQ fellowships.
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NR 55
TC 4
Z9 4
U1 0
U2 3
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0531-5565
EI 1873-6815
J9 EXP GERONTOL
JI Exp. Gerontol.
PD MAR
PY 2021
VL 145
AR 111181
DI 10.1016/j.exger.2020.111181
EA JAN 2021
PG 7
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA QE3OM
UT WOS:000616118500016
PM 33340684
DA 2025-06-11
ER

PT J
AU Chenni, A
   Cherif, FZH
   Chenni, K
   Elius, EE
   Pucci, L
   Yahia, DA
AF Chenni, Abdelkader
   Cherif, Fatima Zohr Hamza
   Chenni, Karima
   Elius, Elif Erdogan
   Pucci, Laura
   Yahia, Dalila Ait
TI Effects of Pumpkin (Cucurbita pepo L.) Seed Protein on Blood
   Pressure, Plasma Lipids, Leptin, Adiponectin, and Oxidative Stress in
   Rats with Fructose-Induced Metabolic Syndrome
SO PREVENTIVE NUTRITION AND FOOD SCIENCE
LA English
DT Article
DE adiponectin; leptin; metabolic syndrome; oxidative stress; pumpkin seed
   protein
ID FATTY LIVER-DISEASE; INSULIN-RESISTANCE; DYSFUNCTION; COMPONENTS;
   RECEPTORS; DENSITY; MODEL; ACID
AB This study evaluates the potential effects of pumpkin seeds protein on blood pressure (BP), plasma adiponectin, leptin levels, and oxidative stress in rats with fructose-induced metabolic syndrome. Twenty four male Wistar albino rats were divided into four groups and fed a 20% casein diet, 20% casein diet supplemented with pumpkin protein, 20% casein diet with 64% D-fructose, or 20% casein diet with pumpkin protein and 64% D-fructose for 8 weeks. Continuous fructose feeding induced an increase in plasma insulin/glucose ratio, BP, insulin and glucose, aspartate aminotransferase, alanine aminotransferase (ALT), alkaline phosphatase (ALP), creatinine, urea, and uric acid levels, and a decrease in the liver and muscle glycogen stores. In addition, elevated levels of total cholesterol (TC), triglycerides (TG), and leptin and lowered adiponectin levels were observed in rats fed a fructose-enriched diet. These groups also exhibited lower plasma levels of ascorbic acid and glutathione, higher thiobarbituric acid-reactive substances, hydroperoxide, carbonyl, and nitric oxide in both the liver and kidneys than rats fed the control diet. Interestingly, pumpkin seed protein treatment significantly counteracted alterations induced by fructose improving glucose, insulin, BP, TG, TC, ALT, and ALP levels, increasing liver and muscle glycogen stores, adiponectin level, and adiponectin/leptin ratio, and reducing plasma leptin levels. In addition, rats fed pumpkin protein with a high-fructose diet improved oxidative stress in the liver and kidneys. In conclusion, proteins from Cucurbita pepo L. seeds effectively improve metabolic parameters and protect against oxidative stress induced by a high-fructose diet.
C1 [Chenni, Abdelkader] Oran Univ Sci & Technol Mohamed Boudiaf, Fac Nat & Life Sci, Dept Biotechnol, Bir El Djir 31000, Algeria.
   [Cherif, Fatima Zohr Hamza; Yahia, Dalila Ait] Univ Oran1 Ahmed Ben Bella, Fac Nat & Life Sci, Dept Biol, Oran 31000, Algeria.
   [Chenni, Karima] Univ Oran1 Ahmed Ben Bella, Fac Med, Biostat & Clin Epidemiol Lab, Oran 31000, Algeria.
   [Elius, Elif Erdogan] Mersin Univ, Tech Sci Vocat Sch, Dept Food Technol, TR-33110 Mersin, Turkey.
   [Pucci, Laura] CNR, Inst Agr Biol & Biotechnol, I-56124 Pisa, Italy.
C3 Mersin University; Consiglio Nazionale delle Ricerche (CNR)
RP Pucci, L (corresponding author), CNR, Inst Agr Biol & Biotechnol, I-56124 Pisa, Italy.
EM pucci@ibba.cnr.it
RI CHERIF, fatima-zahra/AAX-7596-2020; Pucci, Laura/AAU-4653-2020
OI Pucci, Laura/0000-0001-7063-6192; Erdogan Eliuz,
   Elif/0000-0003-4317-3000
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NR 57
TC 3
Z9 4
U1 1
U2 14
PU KOREAN SOC FOOD SCIENCE NUTRITION
PI BUSAN
PA 1010, 993, JUNGANG-DAERO, BUSANJIN-GU, BUSAN, 47209, SOUTH KOREA
SN 2287-1098
EI 2287-8602
J9 PREV NUTR FOOD SCI
JI Prev. Nutr. Food Sci.
PD MAR
PY 2022
VL 27
IS 1
BP 78
EP 88
DI 10.3746/pnf.2022.27.1.78
PG 11
WC Food Science & Technology; Nutrition & Dietetics
WE Emerging Sources Citation Index (ESCI)
SC Food Science & Technology; Nutrition & Dietetics
GA F3UT6
UT WOS:000981636600008
PM 35465120
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Tsatsoulis, A
   Mantzaris, MD
   Bellou, S
   Andrikoula, M
AF Tsatsoulis, Agathocles
   Mantzaris, Michalis D.
   Bellou, Sofia
   Andrikoula, Maria
TI Insulin resistance: An adaptive mechanism becomes maladaptive in the
   current environment - An evolutionary perspective
SO METABOLISM-CLINICAL AND EXPERIMENTAL
LA English
DT Review
DE Metabolic syndrome; Type 2 diabetes; Central obesity; Low-grade
   inflammation; Selfish brain
ID BETA-CELL FAILURE; PROTEIN-KINASE-C; ADIPOSE-TISSUE; METABOLIC-SYNDROME;
   SELFISH BRAIN; INTRAMYOCELLULAR LIPIDS; SIGNALING PATHWAYS; ABDOMINAL
   OBESITY; GLUCOSE-UPTAKE; GROWTH-FACTOR
AB Human survival has relied upon the ability to withstand starvation through energy storage, the capacity to fight off infection by a proinflammatory immune response, and the ability to cope with physical stressors by an adaptive stress response. Energy storage, mainly as glycogen in liver and triglycerides in adipose tissue, is regulated by the anabolic actions of insulin. On the other hand, mobilization of stored energy during infection, trauma or stress is served by the temporary inhibition of insulin action (insulin resistance) in target tissues by proinflammatory cytokines and stress hormones. In the current environment, high energy intake, low physical activity, and chronic stress favor the storage of surplus fat in adipose tissue depots that far exceeds their storage capacity and liporegulation. Lipid overload in central fat depots initiates an inflammatory response and adipocyte dysfunction with resultant low-grade systemic inflammation and lipid overflow to peripheral tissues. In turn, proinflammatory cytoldnes and non-oxidized lipid metabolites, accumulated in liver and muscle cells, activate the mechanism of insulin resistance as would occur in the case of infection or stress. The same factors together with the ensuing insulin resistance further contribute to pancreatic beta-cell dysfunction and ultimately to type 2 diabetes and cardiovascular disease. The present review supports the hypothesis that insulin resistance evolved as a physiological adaptive mechanism in human survival and that the same mechanism is inappropriately activated on a chronic basis in the current environment, leading to the manifestations of the metabolic syndrome. (C) 2013 Elsevier Inc. All rights reserved.
C1 [Tsatsoulis, Agathocles; Andrikoula, Maria] Univ Ioannina, Sch Med, Dept Endocrinol, GR-45110 Ioannina, Greece.
   [Mantzaris, Michalis D.] Univ Ioannina, Sch Med, Biol Chem Lab, GR-45110 Ioannina, Greece.
   [Bellou, Sofia] Fdn Res & Technol Hellas, Inst Mol Biol & Biotechnol, Dept Biomed Res, Ioannina, Greece.
C3 University of Ioannina; University of Ioannina; Foundation for Research
   & Technology - Hellas (FORTH)
RP Tsatsoulis, A (corresponding author), Univ Ioannina, Sch Med, Dept Endocrinol, GR-45110 Ioannina, Greece.
EM atsatsou@uoi.gr
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NR 113
TC 130
Z9 145
U1 1
U2 57
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0026-0495
EI 1532-8600
J9 METABOLISM
JI Metab.-Clin. Exp.
PD MAY
PY 2013
VL 62
IS 5
BP 622
EP 633
DI 10.1016/j.metabol.2012.11.004
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 135BH
UT WOS:000318260500002
PM 23260798
DA 2025-06-11
ER

PT J
AU Taylor, V
   McKinnon, MC
   Macdonald, K
   Jaswal, G
   MacQueen, GM
AF Taylor, Valerie
   McKinnon, Margaret C.
   Macdonald, Kathryn
   Jaswal, Gurpreet
   MacQueen, Glenda M.
TI Adults With Mood Disorders Have an Increased Risk Profile for
   Cardiovascular Disease Within the First 2 Years of Treatment
SO CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE
LA English
DT Article
DE obesity; bipolar major depression; metabolic syndrome; cardiovascular
   disease
ID CORONARY-HEART-DISEASE; METABOLIC SYNDROME; PSYCHIATRIC-DISORDERS;
   BIPOLAR DISORDER; UNITED-STATES; RATING-SCALE; DEPRESSION; MORTALITY;
   OBESITY; HEALTH
AB Objectives: People with bipolar disorder (BD) and major depressive disorder (MDD) are at risk for premature death from various physical illnesses. A large component of this risk may be accounted for by an elevated risk of metabolic syndrome (MeS) and coronary heart disease (CHD). The objective of our study was to examine patients' physical health prior to first treatment and over 2 years of follow-up.
   Methods: Ten-year risk for CHD and incidence of MeS were calculated for newly diagnosed patients with MDD (n = 30) and BD (n = 24) at baseline and over a 2-year follow-up. Age and sex-matched control subjects were obtained from the National Health and Nutrition Examination Survey III dataset.
   Results: At baseline, 11.2% of patients met diagnostic criteria for MeS and this increased to 16.8% at follow-up. Women had higher rates of MeS but rates were similar across diagnosis. There was a significant increase within all MeS criteria. The 10-year CHD risk was low for patients at baseline and follow-up but increased across the follow-up period. Changes in CHD and MeS risk were not associated with a specific type of pharmacotherapy, as all medication classes appeared to increase risk.
   Conclusion: Prior to treatment, MeS and CHD risk rates for patients were similar to the general population, but their risk of CHD increased appreciably.
C1 [Taylor, Valerie; McKinnon, Margaret C.; Macdonald, Kathryn; Jaswal, Gurpreet] McMaster Univ, Dept Psychiat & Behav Neurosci, Hamilton, ON, Canada.
   [MacQueen, Glenda M.] Univ Calgary, Dept Psychiat, Calgary, AB, Canada.
C3 McMaster University; University of Calgary
RP Taylor, V (corresponding author), St Josephs Healthcare, Mood Disorders Program, Ctr Mt Hlth Serv, D150-A,100 W 5th St, Hamilton, ON L8N 3K7, Canada.
EM taylorv@mcmaster.ca
RI McKinnon, Margaret/AAT-5821-2021; Taylor, Valerie/H-6242-2015
OI Taylor, Valerie/0000-0002-8948-638X
FU Etherden and Sluzas Fellowship; St Joseph's Healthcare, Hamilton
FX This work was funded by the Etherden and Sluzas Fellowship for Studies
   in Mood Disorders; a postdoctoral research award given by St Joseph's
   Healthcare, Hamilton, to Dr Taylor. All authors had no conflicts of
   interest to declare.
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NR 40
TC 23
Z9 24
U1 0
U2 7
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0706-7437
EI 1497-0015
J9 CAN J PSYCHIAT
JI Can. J. Psychiat.-Rev. Can. Psychiat.
PD JUN
PY 2010
VL 55
IS 6
BP 362
EP 368
DI 10.1177/070674371005500605
PG 7
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 618IL
UT WOS:000279346000005
PM 20540831
DA 2025-06-11
ER

PT J
AU Molina, JD
   Avila, S
   Rubio, G
   López-Muñoz, F
AF Molina, Juan D.
   Avila, Sonia
   Rubio, Gabriel
   Lopez-Munoz, Francisco
TI Metabolomic Connections between Schizophrenia, Antipsychotic Drugs and
   Meta-bolic Syndrome: A Variety of Players
SO CURRENT PHARMACEUTICAL DESIGN
LA English
DT Review
DE Schizophrenia; metabolic syndrome; metabolomics; second-generation
   antipsychotics; biomarker; gut microbiota; diagnosis
ID GUT MICROBIOME; RISK; ASSOCIATION; RISPERIDONE; DYSFUNCTION; DISORDERS;
   OBESITY; NAIVE; ACID
AB Background: Diagnosis of schizophrenia lacks reliable medical diagnostic tests and robust biomarkers applied to clinical practice. Schizophrenic patients undergoing treatment with antipsychotics suffer reduced life expectancy due to metabolic disarrangements that co-exist with their mental illness and predispose them to develop metabolic syndrome, which is also exacerbated by medication. Metabolomics is an emerging and potent technology able to accelerate this biomedical research. Aim: This review focus on a detailed vision of the molecular mechanisms involved both in schizophrenia and antipsychotic-induced metabolic syndrome, based on innovative metabolites that consistently change in nascent metabolic syndrome, drug-naive, first episode psychosis and/or schizophrenic patients compared to healthy subjects. Main Lines: Supported by metabolomic approaches, although not exclusively, noteworthy variations are reported mainly through serum samples of patients and controls in several scenes: 1) alterations in fatty acids, inflammatory response indicators, amino acids and biogenic amines, biometals, and gut microbiota metabolites (schizophrenia); 2) alterations in metabolites involved in carbohydrate and gut microbiota metabolism, inflammation and oxidative stress (metabolic syndrome), some of them shared with schizophrenia; 3) alterations of cytokines secreted by adipose tissue, phosphatidylcholines, acylcarnitines, Sirtuin 1, orexin-A, and changes in microbiota composition (antipsychotic-induced metabolic syndrome). Conclusion: Novel insights into the pathogenesis of schizophrenia and metabolic side-effects associated with its antipsychotic treatment represent an urgent request for scientists and clinicians. Leptin, carnitines, adiponectin, insulin, or interleukin-6 represent some examples of candidate biomarkers. Cutting-edge technologies like metabolomics have the power to strengthen research for achieving preventive, diagnostic, and therapeutical solutions for schizophrenia.
C1 [Molina, Juan D.; Rubio, Gabriel] 12 Octubre Univ Hosp, Psychiat Serv, Clin Management Area Psychiat & Mental Hlth, Madrid, Spain.
   [Molina, Juan D.; Rubio, Gabriel; Lopez-Munoz, Francisco] Hosp 12 Octubre Res Inst I 12, Madrid, Spain.
   [Molina, Juan D.] Francisco de Vitoria Univ, Fac Hlth Sci, Madrid, Spain.
   [Molina, Juan D.] Ctr Biomed Res Network Mental Hlth CIBERSAM, Madrid, Spain.
   [Avila, Sonia; Rubio, Gabriel] Univ Complutense Madrid, Fac Med, Dept Psychiat, Madrid, Spain.
   [Rubio, Gabriel; Lopez-Munoz, Francisco] MICINN, Carlos III Hlth Inst, RETICS Themat Networks Cooperat Res Hlth, Addict Disorders Network, Madrid, Spain.
   [Rubio, Gabriel; Lopez-Munoz, Francisco] FEDER, Madrid, Spain.
   [Lopez-Munoz, Francisco] Univ Camilo Jose Cela, Fac Hlth Sci, Madrid, Spain.
   [Lopez-Munoz, Francisco] Univ Portucalense, Portucalense Inst Neuropsychol & Cognit & Behav N, Oporto, Portugal.
C3 Hospital Universitario 12 de Octubre; Universidad Francisco de Vitoria;
   CIBER - Centro de Investigacion Biomedica en Red; CIBERSAM; Complutense
   University of Madrid; Camilo Jose Cela University; Universidade
   Portucalense Infante D. Henrique
RP López-Muñoz, F (corresponding author), Univ Camilo Jose Cela, Fac Hlth Sci, Madrid, Spain.
EM flopez@ucjc.edu
RI López-Muñoz, Francisco/AAA-6933-2019; Molina, Juan de dios/S-9616-2018;
   Rubio, Gabriel/O-1752-2018
OI Molina, Juan de dios/0000-0001-8561-8130; AVILA,
   SONIA/0000-0002-8117-3047; Lopez-Munoz, Francisco/0000-0002-5188-6038;
   Rubio, Gabriel/0000-0002-1171-1508
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NR 112
TC 25
Z9 25
U1 1
U2 28
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1381-6128
EI 1873-4286
J9 CURR PHARM DESIGN
JI Curr. Pharm. Design
PY 2021
VL 27
IS 39
BP 4049
EP 4061
DI 10.2174/1381612827666210804110139
PG 13
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Pharmacology & Pharmacy
GA WH4SO
UT WOS:000707669800004
PM 34348619
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Sanz, RL
   Inserra, F
   Menéndez, SG
   Mazzei, L
   Ferder, L
   Manucha, W
AF Sanz, Raul Lelio
   Inserra, Felipe
   Garcia Menendez, Sebastian
   Mazzei, Luciana
   Ferder, Leon
   Manucha, Walter
TI Metabolic Syndrome and Cardiac Remodeling Due to Mitochondrial Oxidative
   Stress Involving Gliflozins and Sirtuins
SO CURRENT HYPERTENSION REPORTS
LA English
DT Review
DE SGLT-2 inhibitors; Cardiovascular diseases; Sirtuins; Oxidative stress;
   Inflammation; Mitochondrial dysfunction
ID PRESERVED EJECTION FRACTION; ANGIOTENSIN-II BLOCKADE; HEART-FAILURE;
   INHIBITOR EMPAGLIFLOZIN; CARDIOVASCULAR OUTCOMES; BETA-HYDROXYBUTYRATE;
   CALORIE RESTRICTION; DIASTOLIC FUNCTION; DEACETYLASE SIRT3; SGLT2
   INHIBITORS
AB Purpose of ReviewTo address the mechanistic pathways focusing on mitochondria dysfunction, oxidative stress, sirtuins imbalance, and other contributors in patient with metabolic syndrome and cardiovascular disease. Sodium glucose co-transporter type 2 (SGLT-2) inhibitors deeply influence these mechanisms. Recent randomized clinical trials have shown impressive results in improving cardiac function and reducing cardiovascular and renal events. These unexpected results generate the need to deepen our understanding of the molecular mechanisms able to generate these effects to help explain such significant clinical outcomes.Recent FindingsCardiovascular disease is highly prevalent among individuals with metabolic syndrome and diabetes. Furthermore, mitochondrial dysfunction is a principal player in its development and persistence, including the consequent cardiac remodeling and events. Another central protagonist is the renin-angiotensin system; the high angiotensin II (Ang II) activity fuel oxidative stress and local inflammatory responses. Additionally, sirtuins decline plays a pivotal role in the process; they enhance oxidative stress by regulating adaptive responses to the cellular environment and interacting with Ang II in many circumstances, including cardiac and vascular remodeling, inflammation, and fibrosis.Fasting and lower mitochondrial energy generation are conditions that substantially reduce most of the mentioned cardiometabolic syndrome disarrangements. In addition, it increases sirtuins levels, and adenosine monophosphate-activated protein kinase (AMPK) signaling stimulates hypoxia-inducible factor-1 beta (HIF-1 beta) and favors ketosis. All these effects favor autophagy and mitophagy, clean the cardiac cells with damaged organelles, and reduce oxidative stress and inflammatory response, giving cardiac tissue protection. In this sense, SGLT-2 inhibitors enhance the level of at least four sirtuins, some located in the mitochondria. Moreover, late evidence shows that SLGT-2 inhibitors mimic this protective process, improving mitochondria function, oxidative stress, and inflammation.Considering the previously described protection at the cardiovascular level is necessary to go deeper in the knowledge of the effects of SGLT-2 inhibitors on the mitochondria function. Various of the protective effects these drugs clearly had shown in the trials, and we briefly describe it could depend on sirtuins enhance activity, oxidative stress reduction, inflammatory process attenuation, less interstitial fibrosis, and a consequent better cardiac function. This information could encourage investigating new therapeutic strategies for metabolic syndrome, diabetes, heart and renal failure, and other diseases.
C1 [Sanz, Raul Lelio; Garcia Menendez, Sebastian; Mazzei, Luciana; Manucha, Walter] Univ Nacl Cuyo, Fac Ciencias Med, Lab Farmacol Expt Basica & Traslac, Dept Patol,Area Farmacol, Mendoza, Argentina.
   [Inserra, Felipe; Ferder, Leon; Manucha, Walter] Univ Maimonides, Buenos Aires, DF, Argentina.
   [Garcia Menendez, Sebastian; Mazzei, Luciana] Consejo Nacl Invest Cient & Tecnol IMBECU CONICET, Inst Med & Biol Expt Cuyo, Mendoza, Argentina.
C3 University Nacional Cuyo Mendoza
RP Manucha, W (corresponding author), Univ Nacl Cuyo, Fac Ciencias Med, Lab Farmacol Expt Basica & Traslac, Dept Patol,Area Farmacol, Mendoza, Argentina.; Manucha, W (corresponding author), Univ Maimonides, Buenos Aires, DF, Argentina.
EM wmanucha@yahoo.com.ar
OI Manucha, Walter/0000-0002-2279-7626
FU Research and Technology Council of Cuyo University (SECyT), Mendoza,
   Argentina; National Agency for the Promotion of Research, Technological
   Development and Innovation ANPCyT FONCyT [PICT 2020-Serie A-4000]
FX This work was supported by grants from the Research and Technology
   Council of Cuyo University (SECyT), Mendoza, Argentina, and from the
   National Agency for the Promotion of Research, Technological Development
   and Innovation ANPCyT FONCyT (Grant no. PICT 2020-Serie A-4000).
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TC 11
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U2 5
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1522-6417
EI 1534-3111
J9 CURR HYPERTENS REP
JI Curr. Hypertens. Rep.
PD JUN
PY 2023
VL 25
IS 6
BP 91
EP 106
DI 10.1007/s11906-023-01240-w
EA APR 2023
PG 16
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA AR4T7
UT WOS:000968316400001
PM 37052810
DA 2025-06-11
ER

PT J
AU Woerdeman, J
   van Poelgeest, E
   Ket, JCF
   Eringa, EC
   Serne, EH
   Smulders, YM
AF Woerdeman, J.
   van Poelgeest, E.
   Ket, J. C. F.
   Eringa, E. C.
   Serne, E. H.
   Smulders, Y. M.
TI Do grape polyphenols improve metabolic syndrome components? A systematic
   review
SO EUROPEAN JOURNAL OF CLINICAL NUTRITION
LA English
DT Review
ID RED WINE POLYPHENOLS; AMBULATORY BLOOD-PRESSURE;
   LOW-DENSITY-LIPOPROTEIN; SEED EXTRACT; VASCULAR FUNCTION; RISK-FACTORS;
   CARDIOVASCULAR-DISEASE; CHRONIC CONSUMPTION; OXIDATIVE STRESS;
   DOUBLE-BLIND
AB BACKGROUND/OBJECTIVES: Epidemiological, in vitro and animal studies suggest that grape polyphenols, such as those present in wine, have favorable effects on the metabolic syndrome. However, controversy remains whether treatment with grape polyphenols is effective in humans. Here, we aimed to systemically review the effects of grape polyphenols on metabolic syndrome components in humans.
   SUBJECTS/METHODS: We systematically searched Medline, EMBASE and the Cochrane database for all clinical trials assessing the effects of grape polyphenols on insulin sensitivity, glycemia, blood pressure or lipid levels. We screened all titles and reviewed abstracts of potentially relevant studies. Full papers were assessed for eligibility and quality-rated according to the Jadad scale by two independent assessors.
   RESULTS: Thirty-nine studies met the eligibility criteria. In individuals without component criteria of the metabolic syndrome, only low-and medium-quality studies were found with primarily neutral results. In individuals with the metabolic syndrome or related conditions, one of two high-quality studies suggested improvement in insulin sensitivity. Glycemia was improved in 2 of 11 lower-quality studies and 2 of 4 high-quality studies. Seven of 22 studies demonstrated a significant decrease in blood pressure, but only one was of high quality. Two of four high-quality studies pointed towards effects on total cholesterol while other lipidemic parameters were not affected.
   CONCLUSIONS: No compelling data exist that grape polyphenols can positively influence glycemia, blood pressure or lipid levels in individuals with or without the metabolic syndrome. Limited evidence suggests that grape polyphenols may improve insulin sensitivity.
C1 [Woerdeman, J.; Serne, E. H.; Smulders, Y. M.] Vrije Univ Amsterdam, Dept Internal Med, Med Ctr, De Boelelaan 1117,Room 4A45, NL-1081 HV Amsterdam, Netherlands.
   [van Poelgeest, E.; Eringa, E. C.] Vrije Univ Amsterdam, Dept Physiol, Med Ctr, Amsterdam, Netherlands.
   [Ket, J. C. F.] VU Univ Lib, Amsterdam, Netherlands.
   [Ket, J. C. F.] Dept Epidemiol & Biostat, Amsterdam, Netherlands.
   [Ket, J. C. F.] EMGO Inst Hlth & Care Res, Amsterdam, Netherlands.
C3 Vrije Universiteit Amsterdam; Vrije Universiteit Amsterdam; Vrije
   Universiteit Amsterdam; Vrije Universiteit Amsterdam
RP Woerdeman, J (corresponding author), Vrije Univ Amsterdam, Dept Internal Med, Med Ctr, De Boelelaan 1117,Room 4A45, NL-1081 HV Amsterdam, Netherlands.
EM j.woerdeman@vumc.nl
RI Eringa, Ed/ABA-3194-2021; Smulders, YM/AAG-7506-2021; Ket,
   Johannes/F-4415-2011; Ket, Johannes C.F./B-7966-2017
OI Serne, Erik/0000-0003-0657-7225; Ket, Johannes C.F./0000-0002-1909-3150;
   Eringa, Etto/0000-0002-9814-5149
FU Dutch heart foundation [2010T041]
FX ES and JW are supported by the Dutch heart foundation (2010T041).
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NR 55
TC 28
Z9 28
U1 0
U2 29
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0954-3007
EI 1476-5640
J9 EUR J CLIN NUTR
JI Eur. J. Clin. Nutr.
PD DEC
PY 2017
VL 71
IS 12
BP 1381
EP 1392
DI 10.1038/ejcn.2016.227
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA FP0CM
UT WOS:000417266700005
PM 28145414
DA 2025-06-11
ER

PT J
AU Aguirre, GA
   De Ita, JR
   de la Garza, RG
   Castilla-Cortazar, I
AF Aguirre, G. A.
   Rodriguez De Ita, J.
   de la Garza, R. G.
   Castilla-Cortazar, I.
TI Insulin-like growth factor-1 deficiency and metabolic syndrome
SO JOURNAL OF TRANSLATIONAL MEDICINE
LA English
DT Review
DE Lipid metabolism; Insulin resistance; Dyslipidemia; Aging; Oxidative
   stress; GH/IGF-I axis; Obesity; Mitochondrial dysfunction; Cellular
   protection
ID CORONARY-HEART-DISEASE; FACTOR-BINDING PROTEIN-3;
   INTERNATIONAL-DIABETES-FEDERATION; HORMONE INSENSITIVITY SYNDROME; 3RD
   NATIONAL-HEALTH; C-REACTIVE PROTEIN; INCIDENT CARDIOVASCULAR-DISEASE;
   CARDIAC CONTRACTILE DYSFUNCTION; IMPROVES GLYCEMIC CONTROL; ADVANCED
   LIVER-CIRRHOSIS
AB Consistent evidence associates IGF-1 deficiency and metabolic syndrome. In this review, we will focus on the metabolic effects of IGF-1, the concept of metabolic syndrome and its clinical manifestations (impaired lipid profile, insulin resistance, increased glucose levels, obesity, and cardiovascular disease), discussing whether IGF-1 replacement therapy could be a beneficial strategy for these patients. The search plan was made in Medline for Pubmed with the following mesh terms: IGF-1 and "metabolism, carbohydrate, lipids, proteins, amino acids, metabolic syndrome, cardiovascular disease, diabetes" between the years 1963-2015. The search includes animal and human protocols. In this review we discuss the relevant actions of IGF-1 on metabolism and the implication of IGF-1 deficiency in the establishment of metabolic syndrome. Multiple studies (in vitro and in vivo) demonstrate the association between IGF-1 deficit and deregulated lipid metabolism, cardiovascular disease, diabetes, and an altered metabolic profile of diabetic patients. Based on the available data we propose IGF-1 as a key hormone in the pathophysiology of metabolic syndrome; due to its implications in the metabolism of carbohydrates and lipids. Previous data demonstrates how IGF-1 can be an effective option in the treatment of this worldwide increasing condition. It has to distinguished that the replacement therapy should be only undertaken to restore the physiological levels, never to exceed physiological ranges.
C1 [Aguirre, G. A.; Rodriguez De Ita, J.; de la Garza, R. G.; Castilla-Cortazar, I.] Tecnol Monterrey, Escuela Med, Monterrey 64710, Nuevo Leon, Mexico.
   [Castilla-Cortazar, I.] Fdn Invest HM Hosp, Madrid, Spain.
C3 Tecnologico de Monterrey
RP Castilla-Cortazar, I (corresponding author), Tecnol Monterrey, Escuela Med, Ave Morones Prieto 3000 Pte Col Doctores, Monterrey 64710, Nuevo Leon, Mexico.
EM iccortazar@itesm.mx
RI ; Castilla-Cortazar, Inma/K-7883-2017; Aguirre, Gabriel A/K-7839-2017
OI Garcia de la Garza, Rocio/0000-0002-0853-5822; Castilla-Cortazar,
   Inma/0000-0002-2230-5927; Aguirre, Gabriel A/0000-0003-4125-2661;
   Rodriguez-de Ita, Julieta/0000-0002-9557-5741
FU Fundacion de Investigacion HM Hospitales; Tecnologico de Monterrey
FX The authors would like to thank every researcher that contributed to the
   understanding of the close relationship between the IGF-1 deficiency and
   the Metabolic Syndrome establishment. The authors wish to express their
   gratitude to Ing. Karl Steinmetz and Tomas Lankenau for their English
   review of the manuscript and Jesus Ortiz Urbina for his generous help.
   This work was possible thank to the financial help of "Fundacion de
   Investigacion HM Hospitales" and "Tecnologico de Monterrey".
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NR 292
TC 211
Z9 234
U1 0
U2 17
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1479-5876
J9 J TRANSL MED
JI J. Transl. Med.
PD JAN 6
PY 2016
VL 14
AR 3
DI 10.1186/s12967-015-0762-z
PG 23
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA DB3EN
UT WOS:000368392900001
PM 26733412
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Vaara, JP
   Kyröläinen, H
   Fogelholm, M
   Santtila, M
   Häkkinen, A
   Häkkinen, K
   Vasankari, T
AF Vaara, Jani P.
   Kyrolainen, Heikki
   Fogelholm, Mikael
   Santtila, Matti
   Hakkinen, Arja
   Hakkinen, Keijo
   Vasankari, Tommi
TI Associations of Leisure Time, Commuting, and Occupational Physical
   Activity With Physical Fitness and Cardiovascular Risk Factors in Young
   Men
SO JOURNAL OF PHYSICAL ACTIVITY & HEALTH
LA English
DT Article
DE cardiometabolic risk factors; exercise; cross-sectional
ID DISEASE RISK; METABOLIC SYNDROME; BLOOD-PRESSURE; CARDIORESPIRATORY
   FITNESS; ACTIVITY QUESTIONNAIRE; EXERCISE; WOMEN; METAANALYSIS;
   RELIABILITY; CAPACITY
AB Background: The aim was to study the relationships between different domains of physical activity and cardiovascular risk factors and physical fitness. Methods: 781 young men participated. Self-reported leisure-time (LTPA), commuting (CPA) and occupational (OPA) activity were determined. Blood pressure, s-HDL-cholesterol, s-triglycerides and s-LDL-cholesterol, and glucose were measured. The continuous cardiovascular disease (CVD) risk factor score was calculated from the z-score mean of each cardiovascular risk factor. The cutpoint was defined as 1 standard deviation above the mean. Cardiorespiratory and muscular fitness were measured. Results: The likelihood of CVD risk factor score was higher in moderate [OR 1.99 (95% CI 1.21-3.28)] and low [1.87 (1.16-3.02)] CPA groups compared with the high group, whereas neither low nor moderate LTPA or OPA groups showed similar associations after adjustments. Low OPA combined either with low LTPA [2.01 (1.08-3.74)] or low CPA [1.90 (1.05-3.44)] had a higher likelihood for CVD risk factor compared with combined moderate-high categories after adjustments. LTPA was positively associated with all physical fitness parameters, CPA with cardiorespiratory fitness and muscular endurance, and OPA with grip strength. Conclusion: The results emphasize the beneficial role of CPA regarding CVD risk factor score and stress the avoidance of low physical activity in its different domains.
C1 [Vaara, Jani P.] Natl Def Univ, Dept Leadership & Mil Pedag, Helsinki, Finland.
   [Kyrolainen, Heikki; Hakkinen, Arja] Univ Jyvaskyla, Dept Biol Phys Act, SF-40100 Jyvaskyla, Finland.
   [Fogelholm, Mikael] Univ Helsinki, Dept Food & Environm Sci, Helsinki, Finland.
   [Santtila, Matti] Finnish Def Forces, Personnel Div Def Command, Helsinki, Finland.
   [Hakkinen, Keijo] Univ Jyvaskyla, Dept Hlth Sci, Jyvaskyla, Finland.
   [Vasankari, Tommi] UKK Inst Hlth Promot Res, Tampere, Finland.
C3 University of Jyvaskyla; University of Helsinki; University of
   Jyvaskyla; UKK Institute
RP Vaara, JP (corresponding author), Natl Def Univ, Dept Leadership & Mil Pedag, Helsinki, Finland.
EM jani.vaara@jyu.fi
RI Singh, Ambrish/W-2163-2017; Vaara, Jani/AAC-4613-2020
OI Fogelholm, Mikael/0000-0001-8110-102X; Hakkinen,
   Arja/0000-0002-5779-1259; Kyrolainen, Heikki/0000-0003-3822-1733
FU Scientific Advisory Board for Defence
FX The authors thank all the test personnel for their work in data
   collection and M.Sc Elina Vaara, University of Jyvaskyla for statistical
   guidance. This work was supported by a grant from the Scientific
   Advisory Board for Defence.
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NR 62
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U1 0
U2 14
PU HUMAN KINETICS PUBL INC
PI CHAMPAIGN
PA 1607 N MARKET ST, PO BOX 5076, CHAMPAIGN, IL 61820-2200 USA
SN 1543-3080
EI 1543-5474
J9 J PHYS ACT HEALTH
JI J. Phys. Act. Health
PD NOV
PY 2014
VL 11
IS 8
BP 1482
EP 1491
DI 10.1123/jpah.2012-0504
PG 10
WC Public, Environmental & Occupational Health
WE Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA CB9FK
UT WOS:000349937200005
PM 24384607
DA 2025-06-11
ER

PT J
AU Cater, M
   Hölter, SM
AF Cater, Masa
   Hoelter, Sabine M.
TI A Pathophysiological Intersection of Diabetes and Alzheimer's Disease
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE diabetes; insulin sensitivity; Alzheimer's disease; brain; cognition;
   depression
ID IMPAIRED GLUCOSE-TOLERANCE; BRAIN INSULIN-RESISTANCE; TRANSGENIC MOUSE
   MODEL; MILD COGNITIVE IMPAIRMENT; GROWTH-FACTOR EXPRESSION; TAU
   PHOSPHORYLATION; OXIDATIVE STRESS; A-BETA; RECEPTOR SUBSTRATE-2; MEMORY
   DYSFUNCTION
AB Diabetes is among the most prevalent diseases of the modern world and is strongly linked to an increased risk of numerous neurodegenerative disorders, although the exact pathophysiological mechanisms are not clear yet. Insulin resistance is a serious pathological condition, connecting type 2 diabetes, metabolic syndrome, and obesity. Recently, insulin resistance has been proven to be connected also to cognitive decline and dementias, including the most prevalent form, Alzheimer's disease. The relationship between diabetes and Alzheimer's disease regarding pathophysiology is so significant that it has been proposed that some presentations of the condition could be termed type 3 diabetes.
C1 [Cater, Masa] Univ Ljubljana, Biotech Fac, Dept Anim Sci, Chair Genet Anim Biotechnol & Immunol, Domzale 1230, Slovenia.
   [Hoelter, Sabine M.] Helmholtz Munich, Inst Dev Genet, D-85764 Neuherberg, Germany.
   [Hoelter, Sabine M.] Tech Univ Munich, Sch Life Sci, D-85354 Freising Weihenstephan, Germany.
C3 University of Ljubljana; Technical University of Munich
RP Hölter, SM (corresponding author), Helmholtz Munich, Inst Dev Genet, D-85764 Neuherberg, Germany.; Hölter, SM (corresponding author), Tech Univ Munich, Sch Life Sci, D-85354 Freising Weihenstephan, Germany.
EM hoelter@helmholtz-muenchen.de
RI ; Holter-Koch, Sabine/N-5868-2014
OI Cater, Masa/0000-0002-2477-5279; Holter-Koch, Sabine/0000-0003-4878-5241
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NR 183
TC 11
Z9 12
U1 2
U2 32
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD OCT
PY 2022
VL 23
IS 19
AR 11562
DI 10.3390/ijms231911562
PG 21
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 5H6EH
UT WOS:000867769900001
PM 36232867
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Wender-Ozegowska, E
   Zawiejska, A
   Michalowska-Wender, G
   Iciek, R
   Wender, M
   Brazert, J
AF Wender-Ozegowska, E.
   Zawiejska, A.
   Michalowska-Wender, G.
   Iciek, R.
   Wender, M.
   Brazert, J.
TI METABOLIC SYNDROME IN TYPE 1 DIABETES MELLITUS. DOES IT HAVE ANY IMPACT
   ON THE COURSE OF PREGNANCY?
SO JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
LA English
DT Article
DE diabetes; metabolic syndrome; oxidative stress; pregnancy
ID RECENT CLINICAL-TRIALS; INSULIN-RESISTANCE; OXIDATIVE STRESS; PITTSBURGH
   EPIDEMIOLOGY; GLYCEMIC CONTROL; COMPLICATIONS; NEPHROPATHY; ASSOCIATION;
   ADIPONECTIN; PROGRESSION
AB To determine whether the symptoms of metabolic syndrome (MS), if accompanied by oxidative stress (OS), in type1 diabetes mellitus (DM) patients could affect the course of pregnancy and the perinatal outcome. Oxidized low density lipoproteins (ox-LDL) and total lipid peroxides (TLP) were studied in 98 pregnant women with type 1 DM in the Ist and IIIrd trimesters. 24% of the participants met the criteria of MS. Vascular complications were significantly more frequent in the MS-group (41.9% vs. 17.4% in the non-MS group, p<0.05). No differences in the markers of OS between the MS and the non-MS groups were noted in either the Ist or the IIIrd trimester. A significant gestational rise in Per-Ox was found in both groups. Chronic hypertension was associated with significant differences in ox-LDL levels in both the Ist and IIIrd trimester. No differences in perinatal outcome, as measured by abnormal birth weight or poor neonatal status (Apgar score<6, umbilical venous and/or arterial pH<7.20), were found. Conclusions: 1) MS in type 1 DM is associated with some changes in markers of oxidative stress, but it poses no additional risk to the course of pregnancy and perinatal outcome in properly controlled and treated pregnant women with type 1 DM. 2) Maternal hypertension is the only component of MS in diabetic pregnancy that is associated with significant changes in markers of oxidative stress. 3) MS is significantly more frequent in diabetic pregnant women with co-existing vascular complications and obesity.
C1 [Wender-Ozegowska, E.; Zawiejska, A.; Iciek, R.; Brazert, J.] Univ Sch Med Sci, Dept Obstet & Womens Dis, PL-60535 Poznan, Poland.
   [Michalowska-Wender, G.; Wender, M.] Univ Sch Med Sci, Dept Neurol, Neurogenet Unit, PL-60535 Poznan, Poland.
RP Wender-Ozegowska, E (corresponding author), Univ Sch Med Sci, Dept Obstet & Womens Dis, 33 Polna St, PL-60535 Poznan, Poland.
EM ewaoz@post.pl
RI Zawiejska, Agnieszka/AAC-7945-2021
OI Brazert, Jacek/0000-0003-1661-6881; ZAWIEJSKA,
   AGNIESZKA/0000-0002-3616-6550; Iciek, Rafal/0000-0001-5025-9350
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NR 39
TC 21
Z9 22
U1 0
U2 3
PU POLISH PHYSIOLOGICAL SOC
PI GRZEGORZECKA
PA JAGIELLONIAN UNIV SCHOOL MED, INST PHYSIOLOGY, 31-531 KRAKOW, 16
   GRZEGORZECKA, POLAND
SN 0867-5910
J9 J PHYSIOL PHARMACOL
JI J. Physiol. Pharmacol.
PD OCT
PY 2011
VL 62
IS 5
BP 567
EP 573
PG 7
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA 873AJ
UT WOS:000298852500010
PM 22204805
DA 2025-06-11
ER

PT J
AU Gall, AJ
   Griffin, GD
AF Gall, A. J.
   Griffin, G. D.
TI Anxiolytic effects of administration of a commercially available
   prebiotic blend of galacto-oligosaccharides and beta glucans in
   Sprague-Dawley rats
SO BENEFICIAL MICROBES
LA English
DT Article
DE anxiety; prebiotic; galacto-oligosaccharides; behaviour; microbiota
ID ELEVATED PLUS-MAZE; ANXIETY-RELATED BEHAVIOR; GUT MICROBIOTA; INTESTINAL
   MICROBIOTA; METABOLIC SYNDROME; STRESS-RESPONSE; ANIMAL-MODELS;
   OPEN-FIELD; BRAIN; RECEPTOR
AB Prebiotics are nondigestible food agents that stimulate the growth of bacteria in the gut, whereas probiotics are live microorganisms that replace or restore beneficial bacteria in the digestive tract. Both agents have been shown to have beneficial qualities within the microbiota-gut-brain axis, but the behavioural effects of prebiotics have been less studied than probiotics. Whereas several studies have shown that prebiotics reduce inflammation and modulate anxiety in animals that are injected with lipopolysacccharides or chronically stressed animals, respectively, it is not yet known how they affect a healthy organism. Here, we tested the behavioural effects of galacto-oligosaccharides and beta glucan as a commercially available prebiotic blend in healthy, naive Sprague-Dawley rats. We used the open field test and elevated plus maze to assess anxiety-like behaviour in controls and in rats that ingested the prebiotic blend in their drinking water. We also used the Morris Water Maze to assess spatial memory performance in controls and prebiotic treated rats. Rats treated with prebiotics spent more time in the intermediate zone of the open field test and in the open arms of the elevated plus maze, and exhibited a shorter latency to enter each of these zones. No significant differences between groups were found in the Morris Water Maze. Our results suggest that whereas prebiotics significantly reduced anxiety-like behaviours, it had no effect on spatial memory performance. Altogether, our data indicate that commercially available prebiotic beta glucan blends have anxiolytic effects in healthy rats.
C1 [Gall, A. J.; Griffin, G. D.] Hope Coll, Dept Psychol, 35 E 12th St, Holland, MI 49423 USA.
   [Gall, A. J.; Griffin, G. D.] Hope Coll, Neurosci Program, 35 E 12th St, Holland, MI 49423 USA.
   [Griffin, G. D.] Hope Coll, Dept Biol, 35 East 12th St, Holland, MI 49423 USA.
C3 Hope College; Hope College; Hope College
RP Gall, AJ (corresponding author), Hope Coll, Dept Psychol, 35 E 12th St, Holland, MI 49423 USA.; Gall, AJ (corresponding author), Hope Coll, Neurosci Program, 35 E 12th St, Holland, MI 49423 USA.
EM gall@hope.edu
RI Gall, Andrew/A-2443-2016
OI Gall, Andrew/0000-0003-1258-0658
FU Neuroscience Program at Hope College
FX We thank undergraduate students in the Introduction to Neuroscience
   course at Hope College for helping us collect data, analyse results, and
   contribute to writing a first draft of this manuscript. This work was
   supported by the Neuroscience Program at Hope College.
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NR 45
TC 3
Z9 3
U1 0
U2 12
PU WAGENINGEN ACADEMIC PUBLISHERS
PI WAGENINGEN
PA PO BOX 220, WAGENINGEN, 6700 AE, NETHERLANDS
SN 1876-2883
EI 1876-2891
J9 BENEF MICROBES
JI Benef. Microbes
PY 2021
VL 12
IS 4
BP 35
EP 43
DI 10.3920/BM2020.0169
PG 9
WC Microbiology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Microbiology; Nutrition & Dietetics
GA UK5QQ
UT WOS:000692024600004
PM 34169805
DA 2025-06-11
ER

PT J
AU Estato, V
   Nascimento, A
   Antunes, B
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   Bousquet, P
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AF Estato, Vanessa
   Nascimento, Alessandro
   Antunes, Barbara
   Gomes, Fabiana
   Coelho, Laura
   Rangel, Raquel
   Garzoni, Luciana
   Daliry, Anissa
   Bousquet, Pascal
   Tibirica, Eduardo
TI Cerebral Microvascular Dysfunction and Inflammation Are Improved by
   Centrally Acting Antihypertensive Drugs in Metabolic Syndrome
SO METABOLIC SYNDROME AND RELATED DISORDERS
LA English
DT Article
DE brain microcirculation; centrally acting antihypertensive drugs;
   high-fat diet consumption; laser speckle contrast imaging
ID OXIDATIVE STRESS; ADIPOSE-TISSUE; NITRIC-OXIDE; ENDOTHELIAL DYSFUNCTION;
   RAT MODEL; INSULIN; RECEPTORS; OBESITY; DAMAGE; ALPHA-2-ADRENOCEPTORS
AB Background: We aimed to investigate the effects of chronic oral treatment with centrally acting antihypertensive drugs, such as clonidine (CLO), an alpha(2)-adrenoceptor agonist, or LNP599, a selective I-1 imidazoline receptor agonist, on brain microvascular function in rats with high-fat diet (HFD)-induced metabolic syndrome.
   Methods: Male Wistar Kyoto rats were maintained on a normal diet (CON) or a HFD for 20 weeks. After this period, the HFD group received oral CLO (0.1 mg/kg), LNP599 (20 mg/kg), or vehicle daily for 4 weeks. Systolic blood pressure and heart rate (HR) were evaluated by photoplethysmography. Functional capillary density, endothelial function, and endothelial-leukocyte interactions in the brain were investigated by intravital video microscopy. Cerebral microcirculatory flow was evaluated by laser speckle contrast imaging. Brain tissue endothelial nitric oxide synthase, oxidative enzyme, and inflammatory marker expression levels were analyzed.
   Results: Metabolic syndrome decreased brain functional capillary density and microvascular blood perfusion, changes accompanied by deficient brain microcirculation vasodilatory responses to acetylcholine. Significant numbers of rolling and adherent leukocytes were also observed in the brain venules. Chronic sympathetic inhibition with clonidine and LNP599 reduced blood pressure and HR. These effects were accompanied by reversals of cerebral capillary rarefaction, improvements in cerebral microvascular blood flow and endothelial function, and decreases in endothelial-leukocyte interactions in the cerebral venules.
   Conclusions: Our results suggest that central sympathetic inhibition exerts beneficial effects by increasing perfusion and reducing inflammatory marker expression and oxidative stress in the brains of rats with metabolic syndrome. Centrally acting antihypertensive drugs may be helpful in regulating cerebral microcirculatory function and vascular inflammation in metabolic syndrome.
C1 [Estato, Vanessa; Nascimento, Alessandro; Antunes, Barbara; Gomes, Fabiana; Rangel, Raquel; Garzoni, Luciana; Daliry, Anissa; Tibirica, Eduardo] Fundacao Oswaldo Cruz, Lab Cardiovasc Invest, Ave Brasil, BR-21045900 Rio De Janeiro, RJ, Brazil.
   [Estato, Vanessa] Owaldo Cruz Fdn, Inst Drug Technol, Rio De Janeiro, Brazil.
   [Coelho, Laura; Garzoni, Luciana] Fundacao Oswaldo Cruz, Lab Innovat Therapies Educ & Bioprod, Rio De Janeiro, Brazil.
   [Bousquet, Pascal] Univ Strasbourg, Fac Med, Lab Neurobiol & Cardiovasc Pharmacol, Strasbourg, France.
   [Tibirica, Eduardo] Natl Inst Cardiol, Rio De Janeiro, Brazil.
C3 Fundacao Oswaldo Cruz; Fundacao Oswaldo Cruz; Universites de Strasbourg
   Etablissements Associes; Universite de Strasbourg
RP Estato, V (corresponding author), Fundacao Oswaldo Cruz, Lab Cardiovasc Invest, Ave Brasil, BR-21045900 Rio De Janeiro, RJ, Brazil.
EM vanessaestato@gmail.com
RI Garzoni, Luciana/KHT-9631-2024; Estato, Vanessa/AAJ-9060-2020; Daliry,
   Anissa/F-6256-2014
OI Daliry, Anissa/0000-0001-7303-0030; Nascimento,
   Alessandro/0000-0003-0588-600X
FU CNPq (Conselho Nacional de Desenvolvimento Cientifico e Tecnologico);
   FAPERJ (Fundacao de Amparo a Pesquisa do Estado do Rio de Janeiro);
   Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro, Brazil
FX This investigation was supported by grants from the CNPq (Conselho
   Nacional de Desenvolvimento Cientifico e Tecnologico), the FAPERJ
   (Fundacao de Amparo a Pesquisa do Estado do Rio de Janeiro), and the
   Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro, Brazil.
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NR 49
TC 13
Z9 16
U1 0
U2 11
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-4196
EI 1557-8518
J9 METAB SYNDR RELAT D
JI Metab. Syndr. Relat. Disord.
PD FEB
PY 2017
VL 15
IS 1
BP 26
EP 35
DI 10.1089/met.2016.0085
PG 10
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA EL1GI
UT WOS:000394368100006
PM 27929741
DA 2025-06-11
ER

PT J
AU McEvoy, LK
   Bergstrom, J
   Tu, X
   Garduno, AC
   Cummins, KM
   Franz, CE
   Lyons, MJ
   Reynolds, CA
   Kremen, WS
   Panizzon, MS
   Laughlin, GA
AF McEvoy, Linda K.
   Bergstrom, Jaclyn
   Tu, Xinming
   Garduno, Alexis C.
   Cummins, Kevin M.
   Franz, Carol E.
   Lyons, Michael J.
   Reynolds, Chandra A.
   Kremen, William S.
   Panizzon, Matthew S.
   Laughlin, Gail A.
TI Moderate Alcohol Use Is Associated with Reduced Cardiovascular Risk in
   Middle-Aged Men Independent of Health, Behavior, Psychosocial, and
   Earlier Life Factors
SO NUTRIENTS
LA English
DT Article
DE ethanol; CVD; diabetes; metabolic syndrome; atherosclerosis
ID CORONARY-HEART-DISEASE; VIETNAM ERA TWIN; METABOLIC SYNDROME;
   SOCIOECONOMIC-STATUS; SOCIAL SUPPORT; ALL-CAUSE; CONSUMPTION; MORTALITY;
   METAANALYSIS; SEVERITY
AB We examined whether the often-reported protective association of alcohol with cardiovascular disease (CVD) risk could arise from confounding. Our sample comprised 908 men (56-67 years), free of prevalent CVD. Participants were categorized into 6 groups: never drinkers, former drinkers, and very light (1-4 drinks in past 14 days), light (5-14 drinks), moderate (15-28 drinks), and at-risk (>28 drinks) drinkers. Generalized linear mixed effect models examined the associations of alcohol use with three established CVD risk scores: The Framingham Risk Score (FRS); the atherosclerotic CVD (ASCVD) risk score; and the Metabolic Syndrome (MetS) Severity score, adjusting for group differences in demographics, body size, and health-related behaviors. In separate models we additionally adjusted for several groups of potentially explanatory factors including socioeconomic status, social support, physical and mental health status, childhood factors, and prior history of alcohol misuse. Results showed lower CVD risk among light and moderate alcohol drinkers, relative to very light drinkers, for all CVD risk scores, independent of demographics, body size, and health-related behaviors. Alcohol-CVD risk associations were robust to further adjustment for several groups of potential explanatory factors. Study limitations include the all-male sample with limited racial and ethnic diversity, and the inability to adjust for sugar consumption and for patterns of alcohol consumption. Although this observational study does not address causation, results show that middle-aged men who consume alcohol in moderation have lower CVD risk and better cardiometabolic health than men who consume little or no alcohol, independent of a variety of health, behavioral, psychosocial, and earlier life factors.
C1 [McEvoy, Linda K.; Bergstrom, Jaclyn; Tu, Xinming; Garduno, Alexis C.; Laughlin, Gail A.] Univ Calif San Diego, Herbert Wertheim Sch Publ Hlth & Human Longev Sci, San Diego, CA 92093 USA.
   [McEvoy, Linda K.] Univ Calif San Diego, Dept Radiol, San Diego, CA 92093 USA.
   [Garduno, Alexis C.] San Diego State Univ, Sch Publ Hlth, Div Epidemiol & Biostat, San Diego, CA 92182 USA.
   [Cummins, Kevin M.] Calif State Univ Fullerton, Dept Publ Hlth, Fullerton, CA 92834 USA.
   [Franz, Carol E.; Kremen, William S.; Panizzon, Matthew S.] Univ Calif San Diego, Dept Psychiat, San Diego, CA 92093 USA.
   [Franz, Carol E.; Kremen, William S.; Panizzon, Matthew S.] Univ Calif San Diego, Ctr Behav Genet Aging, Dept Psychiat, San Diego, CA 92093 USA.
   [Lyons, Michael J.] Boston Univ, Dept Psychol & Brain Sci, Boston, MA 02215 USA.
   [Reynolds, Chandra A.] Univ Calif Riverside, Dept Psychol, Riverside, CA 92521 USA.
C3 University of California System; University of California San Diego;
   University of California System; University of California San Diego;
   California State University System; San Diego State University;
   California State University System; California State University
   Fullerton; University of California System; University of California San
   Diego; University of California System; University of California San
   Diego; Boston University; University of California System; University of
   California Riverside
RP McEvoy, LK (corresponding author), Univ Calif San Diego, Herbert Wertheim Sch Publ Hlth & Human Longev Sci, San Diego, CA 92093 USA.; McEvoy, LK (corresponding author), Univ Calif San Diego, Dept Radiol, San Diego, CA 92093 USA.
EM lkmcevoy@health.ucsd.edu; jbergstrom@health.ucsd.edu;
   x2tu@health.ucsd.edu; agarduno@health.ucsd.edu; kmcummins@fullerton.edu;
   cfranz@health.ucsd.edu; mlyons@bu.edu; chandrar@ucr.edu;
   wkremen@health.ucsd.edu; mspanizzon@health.ucsd.edu;
   glaughlin@health.ucsd.edu
RI Garduno, Alexis/AHC-8284-2022
OI Garduno, Alexis/0000-0003-4453-8817; Bergstrom,
   Jaclyn/0000-0002-0212-0802; Franz, Carol/0000-0002-8987-1755
FU National Institutes of Health [R01 AG062483, R01 AG050595, R01 AG022381,
   R01AG037985, P01 AG055367, T32MH122376]; National Institute on Aging
   [R01AG062483] Funding Source: NIH RePORTER
FX This work was funded by the National Institutes of Health (LM: grant
   number R01 AG062483) (WK, CF, ML grant number: R01 AG050595) (WK grant
   numbers: R01 AG022381, R01AG037985) (WK CF grant number: P01 AG055367)
   (AG: T32MH122376).
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NR 58
TC 14
Z9 14
U1 0
U2 7
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JUN
PY 2022
VL 14
IS 11
AR 2183
DI 10.3390/nu14112183
PG 17
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 1Z3RG
UT WOS:000808745100001
PM 35683983
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Moazzen, H
   Alizadeh, M
AF Moazzen, Hossein
   Alizadeh, Mohammad
TI Effects of Pomegranate Juice on Cardiovascular Risk Factors in Patients
   with Metabolic Syndrome: a Double-Blinded, Randomized Crossover
   Controlled Trial
SO PLANT FOODS FOR HUMAN NUTRITION
LA English
DT Article
DE Metabolic syndrome; Cardiovascular disease; Pomegranate juice; Lipid
   profile
ID BLOOD-PRESSURE; OXIDATIVE STRESS; NITRIC-OXIDE; SUPPLEMENTATION;
   CONSUMPTION; INFLAMMATION; METAANALYSIS; EXTRACT; PUNICALAGIN; PROTECTS
AB The aim of this study is to investigate the simultaneous effect of pomegranate juice on components of the metabolic syndrome, including high sensitive C-reactive protein (hs-CRP) as an inflammatory index and glycemic and lipid profile indices in patients with metabolic syndrome. In a double- blind 2*2 crossover study, 30 individuals suffering from metabolic syndrome received a daily dose of 500 mL pomegranate juice for a period of one week. After one week of wash out period, they received a placebo for one week. Lipid profile, blood glucose control indices including fasting blood glucose, fasting insulin, homeostatic model assessment of insulin resistance (HOMA-IR), systolic and diastolic blood pressure, and hs-CRP were measured at the beginning and end of the study. To analyze the data, a repeated measure analysis of variance and a t-test were performed. The results indicated that in comparison to the placebo, pomegranate juice was more effective in reducing the systolic and diastolic blood pressure (p = 0.00) and hs-CRP (p = 0.018). The level of triglyceride (p = 0.030) and very low-density lipoproteins cholesterol (VLDL-C) (p = 0.014) were increased after the consumption of pomegranate juice, as opposed to the baseline condition. The rest of lipid profile, fasting blood glucose (FBS), insulin, and HOMA-IR of the participants did not show any significant difference. Natural pomegranate juice supplementation lowered the level of systolic and diastolic blood pressure in patients with metabolic syndrome as well as their blood hs-CRP. However, it also increased their triglyceride and VLDL-C.
C1 [Moazzen, Hossein] Urmia Univ Med Sci, Student Res Comm, Serow Highway,POB 5756115111, Orumiyeh, Iran.
   [Alizadeh, Mohammad] Urmia Univ Med Sci, Dept Nutr, Food & Beverages Safety Res Ctr, Fac Med, Serow Highway,POB 5756115111, Orumiyeh, Iran.
C3 Urmia University of Medical Sciences; Urmia University of Medical
   Sciences
RP Alizadeh, M (corresponding author), Urmia Univ Med Sci, Dept Nutr, Food & Beverages Safety Res Ctr, Fac Med, Serow Highway,POB 5756115111, Orumiyeh, Iran.
EM alizade85@yahoo.com
RI Alizadeh, Mohammad/M-5833-2017
OI Alizadeh, Mohammad/0000-0002-0593-1491
FU Urmia University of Medical Sciences
FX This manuscript extracted from a master's thesis in Nutrition and the
   authors would like to thank the Urmia University of Medical Sciences for
   providing the necessary facilities and financial support. We also feel
   obliged to express our gratitude to Dr. Parastu Dorrimanesh for editing
   the manuscript and to all those participating in this study for their
   sincere cooperation.
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NR 33
TC 61
Z9 61
U1 1
U2 20
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0921-9668
EI 1573-9104
J9 PLANT FOOD HUM NUTR
JI Plant Food Hum. Nutr.
PD JUN
PY 2017
VL 72
IS 2
BP 126
EP 133
DI 10.1007/s11130-017-0605-6
PG 8
WC Plant Sciences; Chemistry, Applied; Food Science & Technology; Nutrition
   & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Chemistry; Food Science & Technology; Nutrition &
   Dietetics
GA EX1RL
UT WOS:000403003300003
PM 28303364
DA 2025-06-11
ER

PT J
AU Pechánová, O
   Varga, ZV
   Cebová, M
   Giricz, Z
   Pacher, P
   Ferdinandy, P
AF Pechanova, O.
   Varga, Z. V.
   Cebova, M.
   Giricz, Z.
   Pacher, P.
   Ferdinandy, P.
TI Cardiac NO signalling in the metabolic syndrome
SO BRITISH JOURNAL OF PHARMACOLOGY
LA English
DT Review
ID NITRIC-OXIDE SYNTHASE; ISCHEMIA-REPERFUSION INJURY; SOLUBLE
   GUANYLATE-CYCLASE; LEFT-VENTRICULAR FUNCTION; MYOCARDIAL
   ISCHEMIA/REPERFUSION INJURY; ASYMMETRIC DIMETHYLARGININE ADMA;
   PROLIFERATOR-ACTIVATED RECEPTORS; SPONTANEOUSLY HYPERTENSIVE-RATS;
   SUPEROXIDE-DISMUTASE ACTIVITY; NF-KAPPA-B
AB It is well documented that metabolic syndrome (i.e. a group of risk factors, such as abdominal obesity, elevated blood pressure, elevated fasting plasma glucose, high serum triglycerides and low cholesterol level in high-density lipoprotein), which raises the risk for heart disease and diabetes, is associated with increased reactive oxygen and nitrogen species (ROS/RNS) generation. ROS/RNS can modulate cardiac NO signalling and trigger various adaptive changes in NOS and antioxidant enzyme expressions/activities. While initially these changes may represent protective mechanisms in metabolic syndrome, later with more prolonged oxidative, nitrosative and nitrative stress, these are often exhausted, eventually favouring myocardial RNS generation and decreased NO bioavailability. The increased oxidative and nitrative stress also impairs the NO-soluble guanylate cyclase (sGC) signalling pathway, limiting the ability of NO to exert its fundamental signalling roles in the heart. Enhanced ROS/RNS generation in the presence of risk factors also facilitates activation of redox-dependent transcriptional factors such as NF-B, promoting myocardial expression of various pro-inflammatory mediators, and eventually the development of cardiac dysfunction and remodelling. While the dysregulation of NO signalling may interfere with the therapeutic efficacy of conventional drugs used in the management of metabolic syndrome, the modulation of NO signalling may also be responsible for the therapeutic benefits of already proven or recently developed treatment approaches, such as ACE inhibitors, certain -blockers, and sGC activators. Better understanding of the above-mentioned pathological processes may ultimately lead to more successful therapeutic approaches to overcome metabolic syndrome and its pathological consequences in cardiac NO signalling.
   Linked ArticlesThis article is part of a themed section on Pharmacology of the Gasotransmitters. To view the other articles in this section visit
C1 [Pechanova, O.; Cebova, M.] Slovak Acad Sci, Inst Normal & Pathol Physiol, Bratislava 81371, Slovakia.
   [Pechanova, O.; Cebova, M.] Slovak Acad Sci, Ctr Excellence Regulatory Role Nitr Oxide Civiliz, Bratislava 81371, Slovakia.
   [Pechanova, O.] Comenius Univ, Fac Nat Sci, Bratislava, Slovakia.
   [Varga, Z. V.; Giricz, Z.; Ferdinandy, P.] Semmelweis Univ, Dept Pharmacol & Pharmacotherapy, Cardiometab Res Grp, H-1085 Budapest, Hungary.
   [Pacher, P.] NIAAA, Lab Physiol Studies, NIH, Bethesda, MD USA.
   [Ferdinandy, P.] Pharmahungary Grp, Szeged, Hungary.
C3 Slovak Academy of Sciences; Institute of Normal & Pathological
   Physiology, SAS; Slovak Academy of Sciences; Comenius University
   Bratislava; Semmelweis University; National Institutes of Health (NIH) -
   USA; NIH National Institute on Alcohol Abuse & Alcoholism (NIAAA);
   Pharmahungary Group
RP Pechánová, O (corresponding author), Slovak Acad Sci, Inst Normal & Pathol Physiol, Bratislava 81371, Slovakia.
EM olga.pechanova@savba.sk
RI Ferdinandy, Péter/H-9181-2019; Giricz, Zoltán/B-6990-2008; Pechanova,
   Olga/V-9959-2018; Pacher, Pal/B-6378-2008; Cebova, Martina/V-9501-2018;
   Varga, Zoltan/J-9264-2017
OI Pechanova, Olga/0000-0001-5476-2949; Giricz, Zoltan/0000-0003-2036-8665;
   Pacher, Pal/0000-0001-7036-8108; Cebova, Martina/0000-0003-0132-670X;
   Varga, Zoltan/0000-0002-2758-0784
FU Hungarian Scientific Research Fund [OTKA K109737];  [APVV-0742-10]; 
   [VEGA 2/0183/12];  [2/0144/14]
FX This study was elaborated within the projects APVV-0742-10, VEGA
   2/0183/12 and 2/0144/14, the New Horizons Grant of the European
   Foundation for the Study of Diabetes, Hungarian Scientific Research Fund
   (OTKA K109737) and COST Action BM1005, and the Intramural Program of
   NIH/NIAA. All authors contributed equally on literature search and
   metabolic syndrome models preparation.
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NR 219
TC 56
Z9 57
U1 0
U2 32
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0007-1188
EI 1476-5381
J9 BRIT J PHARMACOL
JI Br. J. Pharmacol.
PD MAR
PY 2015
VL 172
IS 6
SI SI
BP 1415
EP 1433
DI 10.1111/bph.12960
PG 19
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA CC7KL
UT WOS:000350546100003
PM 25297560
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Safiedeen, Z
   Rodríguez-Gómez, I
   Vergori, L
   Soleti, R
   Vaithilingam, D
   Douma, I
   Agouni, A
   Leiber, D
   Dubois, S
   Simard, G
   Zibara, K
   Andriantsitohaina, R
   Martínez, MC
AF Safiedeen, Zainab
   Rodriguez-Gomez, Isabel
   Vergori, Luisa
   Soleti, Raffaella
   Vaithilingam, Dayannath
   Douma, Imene
   Agouni, Abdelali
   Leiber, Denis
   Dubois, Severine
   Simard, Gilles
   Zibara, Kazem
   Andriantsitohaina, Ramaroson
   Martinez, M. Carmen
TI Temporal Cross Talk Between Endoplasmic Reticulum and Mitochondria
   Regulates Oxidative Stress and Mediates Microparticle-Induced
   Endothelial Dysfunction
SO ANTIOXIDANTS & REDOX SIGNALING
LA English
DT Article
DE extracellular vesicles; mitochondria; endoplasmic reticulum; endothelial
   dysfunction; metabolic syndrome
ID NEUTRAL SPHINGOMYELINASE; NADPH OXIDASE; CARDIOVASCULAR-DISEASES;
   ACTIVATION; CELLS; OBESE; RESPIRATION; APOPTOSIS; PROTEINS; PATHWAY
AB Aims: Circulating microparticles (MPs) from metabolic syndrome patients and those generated from apoptotic T cells induce endothelial dysfunction; however, the molecular and cellular mechanism(s) underlying in the effects of MPs remain to be elucidated.
   Results: Here, we show that both types of MPs increased expression of endoplasmic reticulum (ER) stress markers, X-box binding protein 1, p-eukaryotic translation initiation factor 2 a, and CHOP, and nuclear translocation of activating transcription factor 6 on human aortic endothelial cells (HAoECs). MPs decreased in vitro nitric oxide release by HAoECs, whereas in vivo MP injection into mice impaired the endothelium-dependent relaxation induced by acetylcholine. These effects were prevented when ER stress was inhibited, suggesting that ER stress is implicated in the endothelial effects induced by MPs. MPs affected mitochondrial function and evoked sequential increase of cytosolic and mitochondrial reactive oxygen species (ROS). Pharmacological inhibition of ER stress and silencing of neutral sphingomyelinase (SMase) with siRNA abrogated all MP-mediated effects. Neutralization of Fas ligand carried by MPs abolished effects induced by both MP types, whereas neutralization of low-density lipoprotein receptor on endothelial cells prevented T-lymphocyte MP-mediated effects.
   Innovation and Conclusion: Collectively, endothelial dysfunction triggered by MPs involves temporal cross talk between ER and mitochondria with respect to spatial regulation of ROS via the neutral SMase and interaction of MPs with Fas and/or low-density lipoprotein receptor. These results provide a novel molecular insight into the manner MPs mediate vascular dysfunction and allow identification of potential therapeutic targets to treat vascular complications associated with metabolic syndrome.
C1 [Safiedeen, Zainab; Rodriguez-Gomez, Isabel; Vergori, Luisa; Soleti, Raffaella; Vaithilingam, Dayannath; Douma, Imene; Leiber, Denis; Dubois, Severine; Simard, Gilles; Andriantsitohaina, Ramaroson; Martinez, M. Carmen] Univ Angers, Inst Biol Sante, Stress Oxydant & Pathol Metab, INSERM U1063, 4 Rue Larrey, F-49933 Angers, France.
   [Safiedeen, Zainab; Zibara, Kazem] Lebanese Univ, Lab Stem Cells, ER045, DSST,PRASE, Beirut, Lebanon.
   [Agouni, Abdelali] Univ Surrey, Fac Hlth & Med Sci, Guildford, Surrey, England.
   [Dubois, Severine; Simard, Gilles; Andriantsitohaina, Ramaroson; Martinez, M. Carmen] Ctr Hosp Univ Angers, Angers, France.
   [Zibara, Kazem] Lebanese Univ, Dept Biol, Fac Sci 1, Beirut, Lebanon.
   [Agouni, Abdelali] Qatar Univ, Coll Pharm, Doha, Qatar.
C3 Institut National de la Sante et de la Recherche Medicale (Inserm);
   Universite d'Angers; Centre Hospitalier Universitaire d'Angers; Lebanese
   University; University of Surrey; Universite d'Angers; Centre
   Hospitalier Universitaire d'Angers; Lebanese University; Qatar
   University
RP Martínez, MC (corresponding author), Univ Angers, Inst Biol Sante, Stress Oxydant & Pathol Metab, INSERM U1063, 4 Rue Larrey, F-49933 Angers, France.
EM carmen.martinez@univ-angers.fr
RI Martinez, Maria Carmen/LSJ-1622-2024; SOLETI, RAFFAELLA/ABB-5455-2020;
   Agouni, Abdelali/AAP-5298-2020; Rodriguez-Gomez, Isabel/K-8829-2014;
   ANDRIANTSITOHAINA, Ramaroson/H-5286-2018
OI SOLETI, RAFFAELLA/0000-0002-0271-0490; Rodriguez Gomez, Isabel
   Maria/0000-0001-6490-6643; Martinez, M Carmen/0000-0003-3897-7397;
   Zibara, Kazem/0000-0002-9887-072X; Agouni, Abdelali/0000-0002-8363-1582;
   andriantsitohaina, ramaroson/0000-0002-4770-3585
FU Institut National de la Sante et de la Recherche Medicale; Universite
   d'Angers; Centre Hospitalo-Universitaire d'Angers; "Association de
   Specialisation et d'Orientation Scientifique'' from Lebanon
FX We thank M. Wertheimer and SCAHU staff (Universite d'Angers) for taking
   care of animals, G. Hilairet for expert technical assistance for
   confocal microscopy, and the staff of Centre Hospitalo-Universitaire
   d'Angers for analysis of clinical data of METABOL cohort. This work was
   supported by Institut National de la Sante et de la Recherche Medicale,
   Universite d'Angers and Centre Hospitalo-Universitaire d'Angers. Z.S. is
   the recipient of a doctoral fellowship from the "Association de
   Specialisation et d'Orientation Scientifique'' from Lebanon.
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NR 34
TC 41
Z9 43
U1 1
U2 32
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1523-0864
EI 1557-7716
J9 ANTIOXID REDOX SIGN
JI Antioxid. Redox Signal.
PD JAN 1
PY 2017
VL 26
IS 1
BP 15
EP 27
DI 10.1089/ars.2016.6771
PG 13
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA EF6DT
UT WOS:000390421700002
PM 27392575
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Gomes, VA
   Casella-Filho, A
   Chagas, ACP
   Tanus-Santos, JE
AF Gomes, Valeria A.
   Casella-Filho, Antonio
   Chagas, Antonio C. P.
   Tanus-Santos, Jose E.
TI Enhanced concentrations of relevant markers of nitric oxide formation
   after exercise training in patients with metabolic syndrome
SO NITRIC OXIDE-BIOLOGY AND CHEMISTRY
LA English
DT Article
DE Metabolic syndrome; Nitric oxide; Nitrite; Oxidative stress
ID ACUTE PULMONARY THROMBOEMBOLISM; PLASMA NITRITE; PHYSICAL-ACTIVITY;
   OXIDATIVE STRESS; ASYMMETRICAL DIMETHYLARGININE; ENDOTHELIAL
   DYSFUNCTION; BIOLOGICAL-ACTIVITY; DIABETES-MELLITUS; SYNTHASE ACTIVITY;
   RELAXING FACTOR
AB Metabolic syndrome (MetS) denotes a clustering of risk factors that may affect nitric oxide (NO) bioavailability and predispose to cardiovascular diseases, which are delayed by exercise training. However, no previous study has examined how MetS affects markers of NO formation, and whether exercise training increases NO formation in MetS patients. Here, we tested these two hypotheses. We studied 48 sedentary individuals: 20 healthy controls and 28 MetS patients. Eighteen MetS patients were subjected to a 3-month exercise training (E+group), while the remaining 10 MetS patients remained sedentary (E-group). The plasma concentrations of nitrite, cGMP, and ADMA (asymmetrical dimethylarginine: an endogenous nitric oxide synthase inhibitor), and the whole blood nitrite concentrations were determined at baseline and after exercise training using an ozone-based chemiluminescence assay, and commercial enzyme immunoassays. Thiobarbituric acid reactive species (TBA-RS) were measured in the plasma to assess oxidative stress using a fluorometric method. We found that, compared with healthy subjects, patients with MetS have lower concentrations of markers of NO formation, including whole blood nitrite, plasma nitrite, and plasma cGMP, and increased oxidative stress (all P < 0.05). Exercise training increased the concentrations of whole blood nitrite and cGMP, and decreased both oxidative stress and the circulating concentrations of ADMA (both P < 0.05). These findings show clinical evidence for lower endogenous NO formation in patients with MetS, and for improvements in NO formation associated with exercise training in MetS patients. (C) 2008 Elsevier Inc. All rights reserved.
C1 [Tanus-Santos, Jose E.] Univ Sao Paulo, Dept Pharmacol, Fac Med Ribeirao Preto, BR-14049900 Ribeirao Preto, SP, Brazil.
   [Gomes, Valeria A.] Univ Estadual Campinas, Dept Pharmacol, Fac Med Sci, BR-13081970 Campinas, SP, Brazil.
   [Casella-Filho, Antonio; Chagas, Antonio C. P.] Univ Sao Paulo, Atherosclerosis Unit, Heart Inst Incor, Fac Med, Sao Paulo, Brazil.
C3 Universidade de Sao Paulo; Universidade Estadual de Campinas;
   Universidade de Sao Paulo
RP Tanus-Santos, JE (corresponding author), Univ Sao Paulo, Dept Pharmacol, Fac Med Ribeirao Preto, BR-14049900 Ribeirao Preto, SP, Brazil.
EM tanus@fmrp.usp.br
RI Casella-Filho, Antonio/A-1976-2011; Aguiar, Valeria/T-1141-2017
FU Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP-Brazil);
   Conselho Nacional de Desenvolvimento Cientifico a Tecnologico
   (CNPq-Brazil)
FX This study was funded by Fundacao de Amparo a Pesquisa do Estado de Sao
   Paulo (FAPESP-Brazil) and Conselho Nacional de Desenvolvimento
   Cientifico a Tecnologico (CNPq-Brazil).
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NR 45
TC 56
Z9 64
U1 0
U2 4
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 1089-8603
EI 1089-8611
J9 NITRIC OXIDE-BIOL CH
JI Nitric Oxide-Biol. Chem.
PD DEC
PY 2008
VL 19
IS 4
BP 345
EP 350
DI 10.1016/j.niox.2008.08.005
PG 6
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA 377CW
UT WOS:000261230300007
PM 18799138
DA 2025-06-11
ER

PT J
AU Bernini, LJ
   Simao, ANC
   de Souza, AHB
   Alfieri, DF
   Segura, LG
   Costa, GN
   Dichi, I
AF Bernini, Luciana J.
   Colado Simao, Andrea N.
   de Souza, Anthia H. B.
   Alfieri, Daniela F.
   Segura, Liliane G.
   Costa, Giselle N.
   Dichi, Isaias
TI Effect of Bifidobacterium lactis HN019 on inflammatory markers
   and oxidative stress in subjects with and without the metabolic syndrome
SO BRITISH JOURNAL OF NUTRITION
LA English
DT Article
DE Probiotics; Metabolic syndrome; Cytokines; Oxidative stress; Nitrosative
   stress
ID HIGH-FAT-DIET; GUT MICROBIOTA; INSULIN SENSITIVITY; TOTAL HOMOCYSTEINE;
   PROBIOTIC YOGURT; DOUBLE-BLIND; ADIPONECTIN; WOMEN; PARAMETERS;
   MANAGEMENT
AB Beneficial effects of probiotics have been reported on body weight, lipid and carbohydrate metabolism, inflammatory state and oxidative stress in healthy subjects and in many metabolic and inflammatory diseases. The aim of this study was to evaluate the effects of Bifidobacterium lactis HN019 on inflammatory state and nitro-oxidative stress in patients with and without the metabolic syndrome (MetS). The usual diets of the thirty-three subjects were supplemented with probiotic milk for 90 d. Inflammatory markers and oxidative measurements were performed. In relation to the baseline values, subjects in both groups showed a decrease in homocysteine (P=0.02 and P= 0.03, respectively), hydroperoxides (P=0.02 and P=0.01, respectively) and IL-6 levels (P=0.02). increases in adiponectin (P=0.04) and nitric oxide metabolites (NOx, P=0.001) levels were only seen in the group with the MetS in relation to the baseline values, whereas only the individuals without the MetS had increases in total radical-trapping antioxidant parameter levels (P=0.002). In conclusion, B. lactis HN019 have several beneficial effects on inflammatory and oxidative biomarkers in healthy subjects and the MetS patients. Patients with the MetS showed a specific improvement in adiponectin and NOx levels, whereas a specific favourable effect was shown in the antioxidant defenses in healthy subjects. If the results obtained in the present study are confirmed, supplementation of fermented milk with probiotics in healthy subjects and patients with the MetS must be further discussed.
C1 [Bernini, Luciana J.; de Souza, Anthia H. B.; Segura, Liliane G.; Costa, Giselle N.] Pitagoras UNOPAR Londrina, Programa Mestrado Ciencia Tecnol Leite & Dolvados, BR-86041140 Londrina, Parana, Brazil.
   [Colado Simao, Andrea N.] Univ Estadual Londrina, Dept Patol Anal Clin & Toxicol, BR-86038440 Londrina, Parana, Brazil.
   [Colado Simao, Andrea N.; Alfieri, Daniela F.] Univ Estadual Londrina, Lab Imunol Aplicada, BR-86038440 Londrina, Parana, Brazil.
   [Dichi, Isaias] Univ Estadual Londrina, Dept Med Interna, BR-86038440 Londrina, Parana, Brazil.
C3 Universidade Estadual de Londrina; Universidade Estadual de Londrina;
   Universidade Estadual de Londrina
RP Costa, GN (corresponding author), Pitagoras UNOPAR Londrina, Programa Mestrado Ciencia Tecnol Leite & Dolvados, BR-86041140 Londrina, Parana, Brazil.
EM gcnobre@gmail.com
RI Costa, Giselle/N-2541-2013; Simão, Andrea/AAM-4892-2021; Alfieri,
   Daniela/LSI-6403-2024
OI Alfieri, Daniela/0000-0002-0217-9329; Costa, Giselle
   Nobre/0000-0001-6231-9445
FU PROSUP - Programa de Suporte a Pos-Graduacao de Instituicoes de Ensino
   Particulares; Fundacao Nacional de Desenvolvimento de Ensino Superior
   Particular
FX The authors thank the CONFEPAR - Agro-Industrial Cooperativa Central for
   milk donation, Duas Rodas Industrial for flavors donation and the PROSUP
   - Programa de Suporte a Pos-Graduacao de Instituicoes de Ensino
   Particulares - for financial support to L. G. S. This work was supported
   by Fundacao Nacional de Desenvolvimento de Ensino Superior Particular.
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NR 71
TC 38
Z9 41
U1 1
U2 34
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1145
EI 1475-2662
J9 BRIT J NUTR
JI Br. J. Nutr.
PD SEP 28
PY 2018
VL 120
IS 6
BP 645
EP 652
DI 10.1017/S0007114518001861
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA GS3QO
UT WOS:000443535000005
PM 30058513
OA Bronze
DA 2025-06-11
ER

PT J
AU de Meijer, VE
   Le, HD
   Meisel, JA
   Puder, M
AF de Meijer, Vincent E.
   Le, Hau D.
   Meisel, Jonathan A.
   Puder, Mark
TI Repetitive orogastric gavage affects the phenotype of diet-induced obese
   mice
SO PHYSIOLOGY & BEHAVIOR
LA English
DT Article
DE Mouse; Diet-induced obesity; Fatty liver; Steatosis; Orogastric gavage;
   Laboratory routines; Behavior; Stress
ID FATTY LIVER-DISEASE; METABOLIC SYNDROME; OROPHARYNGEAL CAVITY; HEPATIC
   STEATOSIS; BODY-WEIGHT; STRESS; VULNERABILITY; PREVALENCE; STRAINS;
   PLASMA
AB Interest in pharmacological intervention to combat metabolic syndrome and its complications is increasing as the prevalence of obesity is reaching epidemic proportions. The potential efficacy of drugs is often tested in animal models; however, the method of drug delivery is frequently overlooked and may act as a confounder due to stress. We hypothesized that long-term orogastric gavage would negatively influence the development of hepatic steatosis and the metabolic syndrome in a murine model of diet-induced obesity. C57BL/6J male mice were fed a high fat diet and were gavaged with a vehicle once or twice daily for 9 weeks. A group without orogastric gavaging served as control. A similar experiment was performed using leptin deficient ob/ob mice that were fed a standard diet for 4 weeks. Food intake was monitored, insulin resistance determined, and steatosis was assessed by histology and quantified via magnetic resonance spectroscopy. After 9 weeks, control C57BL/6J mice exhibited significantly more weight gain, insulin resistance and hepatic steatosis, compared to mice that were gavaged daily, or twice daily. This effect was likely due to decreased food consumption associated with gavage-induced stress. In contrast, the phenotype of leptin deficient ob/ob mice was not affected by orogastric gavage. Therefore, we concluded that orogastric gavage may lead to increased stress, thereby affecting food intake and the development of diet-induced obesity in a murine model. The effects of what may seem to be trivial laboratory routines, such as orogastric gavage, should be taken into account when designing animal studies for drug development. (C) 2010 Elsevier Inc. All rights reserved.
C1 [de Meijer, Vincent E.; Le, Hau D.; Meisel, Jonathan A.; Puder, Mark] Childrens Hosp Boston, Dept Surg, Boston, MA USA.
   [de Meijer, Vincent E.; Le, Hau D.; Meisel, Jonathan A.; Puder, Mark] Childrens Hosp Boston, Vasc Biol Program, Boston, MA USA.
   [de Meijer, Vincent E.; Le, Hau D.; Meisel, Jonathan A.; Puder, Mark] Harvard Univ, Sch Med, Cambridge, MA 02138 USA.
   [de Meijer, Vincent E.] Erasmus MC Univ Med Ctr Rotterdam, Dept Surg, Rotterdam, Netherlands.
C3 Harvard University; Harvard University Medical Affiliates; Boston
   Children's Hospital; Harvard University; Harvard University Medical
   Affiliates; Boston Children's Hospital; Harvard University; Erasmus
   University Rotterdam; Erasmus MC
RP Puder, M (corresponding author), 300 Longwood Ave,Fegan 3, Boston, MA 02115 USA.
EM v.demeijer@erasmusmc.nl; hau.le@childrens.harvard.edu;
   jmeisel@bidmc.harvard.edu; mark.puder@childrens.harvard.edu
RI de Meijer, Vincent E./H-6610-2019
OI de Meijer, Vincent E./0000-0002-7900-5917; Le, Hau/0000-0003-0514-3513
FU foundations Stichting Prof. Michael-van Vloten Fonds (Venray, The
   Netherlands); VSBfonds (Utrecht, The Netherlands); Gerrit Jan Mulder
   Stichting (Rotterdam, The Netherlands); Prins Bernhard Cultuurfonds
   (Amsterdam, The Netherlands); National Institutes of Health
   [DK069621-05]; Children's Hospital Surgical Foundation
FX Dr. De Meijer was recipient of fellowships from the foundations
   Stichting Prof. Michael-van Vloten Fonds (Venray, The Netherlands),
   VSBfonds (Utrecht, The Netherlands), Gerrit Jan Mulder Stichting
   (Rotterdam, The Netherlands), Prins Bernhard Cultuurfonds (Amsterdam,
   The Netherlands), and Dr. Saal van Zwanenberg Stichting (Oss, The
   Netherlands). Dr. Le was the recipient of the Joshua Ryan Rappaport
   Fellowship (Boston, MA). Dr. Puder was supported by the National
   Institutes of Health (grant DK069621-05) and the Children's Hospital
   Surgical Foundation (Boston, MA). The funders did not participate in the
   design and conduct of the study; collection, management, analysis, and
   interpretation of the data; and preparation, review, or approval of the
   manuscript.
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NR 25
TC 30
Z9 36
U1 0
U2 7
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0031-9384
J9 PHYSIOL BEHAV
JI Physiol. Behav.
PD JUN 16
PY 2010
VL 100
IS 4
BP 387
EP 393
DI 10.1016/j.physbeh.2010.04.001
PG 7
WC Psychology, Biological; Behavioral Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Behavioral Sciences
GA 614LH
UT WOS:000279059800018
PM 20385157
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Takatsu, M
   Nakashima, C
   Takahashi, K
   Murase, T
   Hattori, T
   Ito, H
   Murohara, T
   Nagata, K
AF Takatsu, Miwa
   Nakashima, Chieko
   Takahashi, Keiji
   Murase, Tamayo
   Hattori, Takuya
   Ito, Hiromi
   Murohara, Toyoaki
   Nagata, Kohzo
TI Calorie Restriction Attenuates Cardiac Remodeling and Diastolic
   Dysfunction in a Rat Model of Metabolic Syndrome
SO HYPERTENSION
LA English
DT Article
DE calorie restriction; cardiac remodeling; ventricular; diastolic heart
   failure; hypertension; inflammation; metabolic syndrome; oxidative
   stress; renin; angiotensin system
ID LEFT-VENTRICULAR GEOMETRY; OXIDATIVE STRESS; ANIMAL-MODEL;
   DAHLS.Z-LEPR(FA)/LEPR(FA) RATS; DIETARY RESTRICTION; BLOOD-PRESSURE;
   OBESITY; HYPERTENSION; LEPTIN; HYPERTROPHY
AB Calorie restriction (CR) can modulate the features of obesity-related metabolic and cardiovascular diseases. We have recently characterized DahlS.Z-Lepr(fa)/Lepr(fa) (DS/obese) rats, derived from a cross between Dahl salt-sensitive and Zucker rats, as a new animal model of metabolic syndrome. DS/obese rats develop hypertension and manifest left ventricular remodeling and diastolic dysfunction, as well as increased cardiac oxidative stress and inflammation. We have now investigated the effects of CR on cardiac pathophysiology in DS/obese rats. DS/obese rats were fed either normal laboratory chow ad libitum or a calorie-restricted diet (65% of the average food intake for ad libitum) from 9 to 13 weeks. Age-matched homozygous lean (DahlS.Z-Lepr(+)/Lepr(+) or DS/lean) littermates served as controls. CR reduced body weight in both DS/obese and DS/lean rats, as well as attenuated the development of hypertension in DS/obese rats without affecting blood pressure in DS/lean rats. CR also reduced body fat content, ameliorated left ventricular hypertrophy, fibrosis, and diastolic dysfunction, and attenuated cardiac oxidative stress and inflammation in DS/obese rats. In addition, it increased serum adiponectin concentration, as well as downregulated the expression of angiotensin-converting enzyme and angiotensin II type 1A receptor genes in the heart of DS/obese rats. Our results thus show that CR attenuated obesity and hypertension, as well as left ventricular remodeling and diastolic dysfunction in DS/obese rats, with these latter effects being associated with reduced cardiac oxidative stress and inflammation.
C1 [Takatsu, Miwa; Takahashi, Keiji; Murase, Tamayo; Hattori, Takuya; Ito, Hiromi; Nagata, Kohzo] Nagoya Univ, Grad Sch Med, Dept Pathophysiol Lab Sci, Nagoya, Aichi 4618673, Japan.
   [Murohara, Toyoaki] Nagoya Univ, Dept Cardiol, Grad Sch Med, Nagoya, Aichi 4618673, Japan.
   [Nakashima, Chieko] Nagoya Univ, Sch Hlth Sci, Dept Med Technol, Nagoya, Aichi 4618673, Japan.
C3 Nagoya University; Nagoya University; Nagoya University
RP Nagata, K (corresponding author), Nagoya Univ, Grad Sch Med, Dept Pathophysiol Lab Sci, Higashi Ku, 1-1-20 Daikominami, Nagoya, Aichi 4618673, Japan.
EM nagata@met.nagoya-u.ac.jp
RI Murohara, Toyoaki/M-4958-2014
FU Astellas Pharma Inc (Tokyo, Japan); Mochida Pharmaceuticals Co Ltd
   (Tokyo, Japan); Japanese government
FX This work was supported, in part, by research grants from Astellas
   Pharma Inc (Tokyo, Japan) and from Mochida Pharmaceuticals Co Ltd
   (Tokyo, Japan), as well as by Management Expenses Grants from the
   Japanese government to Nagoya University.
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NR 45
TC 68
Z9 75
U1 0
U2 9
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0194-911X
EI 1524-4563
J9 HYPERTENSION
JI Hypertension
PD NOV
PY 2013
VL 62
IS 5
BP 957
EP 965
DI 10.1161/HYPERTENSIONAHA.113.02093
PG 9
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 295IO
UT WOS:000330110000036
PM 24041949
OA Bronze
DA 2025-06-11
ER

PT J
AU Nagase, T
   Akase, T
   Sanada, H
   Minematsu, T
   Ibuki, A
   Huang, LJ
   Asada, M
   Yoshimura, K
   Nagase, M
   Shimada, T
   Aburada, M
   Nakagami, G
   Sugama, J
AF Nagase, Takashi
   Akase, Tomoko
   Sanada, Hiromi
   Minematsu, Takeo
   Ibuki, Ai
   Huang, Lijuan
   Asada, Mayumi
   Yoshimura, Kotaro
   Nagase, Miki
   Shimada, Tsutomu
   Aburada, Masaki
   Nakagami, Gojiro
   Sugama, Junko
TI Aging-like skin changes in metabolic syndrome model mice are mediated by
   mineralocorticoid receptor signaling
SO AGING CELL
LA English
DT Article
DE metabolic syndrome; mineralocorticoid receptor; oxidative stress; skin
   aging; spironolactone; ultraviolet
ID OXIDATIVE STRESS; HEME OXYGENASE; ALDOSTERONE; NEPHROPATHY; PERSPECTIVE;
   DYSFUNCTION; EPLERENONE; EXPRESSION; LONGEVITY; BLOCKADE
AB Aging is accelerated, at least in part, by pathological condition such as metabolic syndrome (MetS), and various molecular pathways such as oxidative stress are common mediators of aging and MetS. We previously developed the aging-like skin model by single ultraviolet (UV) irradiation on the MetS model mice. Recent studies revealed that mineralocorticoid receptor (MR) signaling plays a pivotal role for various tissue inflammation and damages in MetS. Although previous studies reported that MR is expressed in the skin and that overexpression of MR in the skin resulted in the skin atrophy, the physiological or pathological functions of MR in the skin are not fully elucidated. Here, we show the involvement of MR signaling in the aging-like skin changes in our own model. Elevations of oxidative stress and inflammation markers were observed in the MetS mice, and the UV-evoked aging-like skin damages were attenuated by topical antioxidant. MR expression was higher in the MetS mouse skin, and notably, expression of its effecter gene Sgk1 was significantly upregulated in the aging-like skin in the UV-irradiated MetS mice. Furthermore, topical application of MR antagonist spironolactone suppressed Sgk1 expression, oxidative stress, inflammation, and the aging-like changes in the skin. The 2-week UV onto the non-MetS mice, the more usual photoaging model, resulted in the skin damages mostly equivalent to the MetS mice with single UV, but they were not associated with upregulation of MR signaling. Our studies suggested an unexpected role of MR signaling in the skin aging in MetS status.
C1 [Sanada, Hiromi] Univ Tokyo, Grad Sch Med, Dept Gerontol Nursing Wound Care Management, Bunkyo Ku, Tokyo 1130033, Japan.
   [Yoshimura, Kotaro] Univ Tokyo, Grad Sch Med, Dept Plast & Reconstruct Surg, Tokyo 1130033, Japan.
   [Nagase, Miki] Univ Tokyo, Grad Sch Med, Dept Chron Kidney Dis, Tokyo 1130033, Japan.
   [Shimada, Tsutomu] Musashino Univ, Pharmaceut Sci Res Inst, Tokyo 2020023, Japan.
   [Aburada, Masaki] Musashino Univ, Fac Pharm, Tokyo 2020023, Japan.
   [Sugama, Junko] Kanazawa Univ, Grad Sch Med, Dept Nursing, Kanazawa, Ishikawa 9200942, Japan.
C3 University of Tokyo; University of Tokyo; University of Tokyo; Kanazawa
   University
RP Sanada, H (corresponding author), Univ Tokyo, Grad Sch Med, Dept Gerontol Nursing Wound Care Management, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1130033, Japan.
EM hsanada-tky@umin.ac.jp
RI SUGAMA, Junko/J-8410-2015; Nakagami, Gojiro/V-9093-2019; Yoshimura,
   Kotaro/C-8524-2009
OI Yoshimura, Kotaro/0000-0002-7152-5475; Nakagami,
   Gojiro/0000-0002-9650-2464; Minematsu, Takeo/0000-0001-5859-7290
FU MEXT (Ministry of Education Culture, Sports, Science and Technology)
   [21659494]; Grants-in-Aid for Scientific Research [24593252, 13J10062,
   21659494, 23249088, 24390214] Funding Source: KAKEN
FX The authors express sincere thanks to Dr. Celso Gomez-Sanches for
   providing us a MR monoclonal antibody, Dr. Hitomi Eto for her technical
   assistance for the confocal endoscope and to Professor Kiyoshi Kita for
   instructing us to use the real-time RT-PCR system. This work was
   supported by a grant-in-aid for Scientific Research from MEXT (Ministry
   of Education Culture, Sports, Science and Technology) (No. 21659494).
   There is no conflict of interest.
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NR 44
TC 29
Z9 30
U1 1
U2 22
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1474-9718
EI 1474-9726
J9 AGING CELL
JI Aging Cell
PD FEB
PY 2013
VL 12
IS 1
BP 50
EP 57
DI 10.1111/acel.12017
PG 8
WC Cell Biology; Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Geriatrics & Gerontology
GA 073LS
UT WOS:000313745100007
PM 23072361
OA hybrid
DA 2025-06-11
ER

PT J
AU Ibarra-Lara, L
   Sánchez-Aguilar, M
   Sánchez-Mendoza, A
   Del Valle-Mondragón, L
   Soria-Castro, E
   Carreón-Torres, E
   Díaz-Díaz, E
   Vázquez-Meza, H
   Guarner-Lans, V
   Rubio-Ruiz, ME
AF Ibarra-Lara, Luz
   Sanchez-Aguilar, Maria
   Sanchez-Mendoza, Alicia
   Del Valle-Mondragon, Leonardo
   Soria-Castro, Elizabeth
   Carreon-Torres, Elizabeth
   Diaz-Diaz, Eulises
   Vazquez-Meza, Hector
   Guarner-Lans, Veronica
   Esther Rubio-Ruiz, Maria
TI Fenofibrate Therapy Restores Antioxidant Protection and Improves
   Myocardial Insulin Resistance in a Rat Model of Metabolic Syndrome and
   Myocardial Ischemia: The Role of Angiotensin II
SO MOLECULES
LA English
DT Article
DE metabolic syndrome; insulin resistance; myocardial ischemia;
   fenofibrate; oxidative stress; angiotensin II
ID TYPE-1 RECEPTOR ANTAGONIST; NITRIC-OXIDE SYNTHASE; PPAR-ALPHA; OXIDATIVE
   STRESS; CARDIAC DYSFUNCTION; AT(1) RECEPTOR; NADPH OXIDASE; ACTIVATION;
   STIMULATION; EXPRESSION
AB Renin-angiotensin system (RAS) activation promotes oxidative stress which increases the risk of cardiac dysfunction in metabolic syndrome (MetS) and favors local insulin resistance. Fibrates regulate RAS improving MetS, type-2 diabetes and cardiovascular diseases. We studied the effect of fenofibrate treatment on the myocardic signaling pathway of Angiotensin II (Ang II)/Angiotensin II type 1 receptor (AT1) and its relationship with oxidative stress and myocardial insulin resistance in MetS rats under heart ischemia. Control and MetS rats were assigned to the following groups: (a) sham; (b) vehicle-treated myocardial infarction (MI) (MI-V); and (c) fenofibrate-treated myocardial infarction (MI-F). Treatment with fenofibrate significantly reduced triglycerides, non-high density lipoprotein cholesterol (non-HDL-C), insulin levels and insulin resistance index (HOMA-IR) in MetS animals. MetS and MI increased Ang II concentration and AT1 expression, favored myocardial oxidative stress (high levels of malondialdehyde, overexpression of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 4 (NOX4), decreased total antioxidant capacity and diminished expression of superoxide dismutase (SOD)1, SOD2 and catalase) and inhibited expression of the insulin signaling cascade: phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PkB, also known as Akt)/Glut-4/endothelial nitric oxide synthase (eNOS). In conclusion, fenofibrate treatment favors an antioxidant environment as a consequence of a reduction of the Ang II/AT1/NOX4 signaling pathway, reestablishing the cardiac insulin signaling pathway. This might optimize cardiac metabolism and improve the vasodilator function during myocardial ischemia.
C1 [Ibarra-Lara, Luz; Sanchez-Aguilar, Maria; Sanchez-Mendoza, Alicia; Del Valle-Mondragon, Leonardo] Dept Pharmacol, Juan Badiano 1,Secc 16, Mexico City 14080, DF, Mexico.
   [Soria-Castro, Elizabeth] Dept Pathol, Juan Badiano 1,Secc 16, Mexico City 14080, DF, Mexico.
   [Carreon-Torres, Elizabeth] Dept Mol Biol, Juan Badiano 1,Secc 16, Mexico City 14080, DF, Mexico.
   [Diaz-Diaz, Eulises] Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Reprod Biol, Vasco de Quiroga 15,Secc 16, Mexico City 14000, DF, Mexico.
   [Vazquez-Meza, Hector] Univ Nacl Autonoma Mexico, Fac Med, Dept Bioquim, Ciudad Univ, Mexico City 04510, DF, Mexico.
   [Guarner-Lans, Veronica; Esther Rubio-Ruiz, Maria] Inst Nacl Cardiol Ignacio Chavez, Dept Physiol, Juan Badiano 1,Secc 16, Mexico City 14080, DF, Mexico.
C3 Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran -
   Mexico; Universidad Nacional Autonoma de Mexico; National Institute of
   Cardiology - Mexico
RP Rubio-Ruiz, ME (corresponding author), Inst Nacl Cardiol Ignacio Chavez, Dept Physiol, Juan Badiano 1,Secc 16, Mexico City 14080, DF, Mexico.
EM luzibarralara@gmail.com; msanchezaguilar@gmail.com; masanchez@gmail.com;
   leonardodvm65@hotmail.com; sorieli@hotmail.com; qfbelizabethcm@yahoo.es;
   eulisesd@yahoo.com; hvazquez@bq.unam.mx; gualanv@yahoo.com;
   esther_rubio_ruiz@yahoo.com
RI Guarner-Lans, Verónica/AFW-3723-2022
OI Carreon-Torres, Elizabeth/0000-0003-3600-249X; Ibarra-Lara, Maria de la
   Luz/0000-0002-5106-5117; Vazquez-Meza, Hector/0000-0002-8312-3115;
   Sanchez Aguilar, Maria/0000-0002-6697-0208; del Valle-Mondragon,
   Leonardo/0000-0002-2999-1050; Guarner-Lans,
   Veronica/0000-0002-2655-7590; Rubio-Ruiz, Maria
   Esther/0000-0002-8844-2078
FU Consejo Nacional de Ciencia y Tecnologia (CONACyT) [222720]
FX The authors thank Consejo Nacional de Ciencia y Tecnologia (CONACyT) for
   the Grant 222720 to Alicia Sanchez-Mendoza. The authors also thank Rocio
   Torrico-Lavayen, Jose Saul Carreon Cervantes, Mario Perez and Florencio
   Hernandez for the excellent technical assistance.
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NR 49
TC 25
Z9 26
U1 0
U2 1
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1420-3049
J9 MOLECULES
JI Molecules
PD JAN
PY 2017
VL 22
IS 1
AR 31
DI 10.3390/molecules22010031
PG 17
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA EM7EE
UT WOS:000395473500031
PM 28036029
OA gold, Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Boiko, AS
   Mednova, IA
   Kornetova, EG
   Bokhan, NA
   Semke, AV
   Loonen, AJM
   Ivanova, SA
AF Boiko, Anastasiia S.
   Mednova, Irina A.
   Kornetova, Elena G.
   Bokhan, Nikolay A.
   Semke, Arkadiy, V
   Loonen, Anton J. M.
   Ivanova, Svetlana A.
TI Cortisol and DHEAS Related to Metabolic Syndrome in Patients with
   Schizophrenia
SO NEUROPSYCHIATRIC DISEASE AND TREATMENT
LA English
DT Article
DE schizophrenia; metabolic syndrome; acute relapse; cortisol;
   dehydroepiandrosterone; female
ID BIPOLAR DISORDER; DEHYDROEPIANDROSTERONE DHEA; GENDER-DIFFERENCES;
   TESTOSTERONE; RISK; METAANALYSIS; HEALTH; TISSUE; RATIO
AB Background: Both dehydroepiandrosterone (DHEAS) and cortisol are secreted by the adrenal glands and may modulate metabolic syndrome (MetS), which often affects the health of patients with schizophrenia. The relationship between the serum levels of these hormones and MetS has not been established.
   Purpose: In this pilot study, we investigated the serum levels in schizophrenia patients with and without MetS and compared them with those in healthy volunteers.
   Patients and Methods: After obtaining informed consent, 110 patients with acute paranoid schizophrenia were recruited directly after admission to the Mental Health Research Institute. The control group consisted of 51 persons reported on questioning to be mentally and somatically healthy. Blood samples to prepare serum were drawn after an 8-h overnight fast during one of the first days of admission. Serum cortisol and DHEAS concentrations were quantified by enzyme-linked immunosorbent assay.
   Results: A total of 42 patients had MetS and 68 patients were without MetS. The cortisol blood level was significantly (p = 0.012) higher in schizophrenia patients without MetS in comparison to healthy controls, while patients with schizophrenia and a MetS have significantly (p = 0.014) lower DHEAS levels than healthy volunteers. These differences could, however, exclusively be attributed to female participants. Analysis of covariance adjusted for gender and age demonstrated a significant relationship between age and DHEAS levels (F = 9.512, p = 0.003).
   Conclusion: Lower DHEAS serum levels in relationship to MetS become evident in women, but not in men, and have age differences as a confounding factor.
C1 [Boiko, Anastasiia S.; Mednova, Irina A.; Kornetova, Elena G.; Bokhan, Nikolay A.; Semke, Arkadiy, V; Ivanova, Svetlana A.] Russian Acad Sci, Mental Hlth Res Inst, Tomsk Natl Res Med Ctr, Tomsk, Russia.
   [Kornetova, Elena G.] Siberian State Med Univ, Tomsk, Russia.
   [Bokhan, Nikolay A.; Ivanova, Svetlana A.] Siberian State Med Univ, Psychiat Addictol & Psychotherapy, Tomsk, Russia.
   [Loonen, Anton J. M.] Univ Groningen, PharmacoTherapy Epidemiol & Econ, Groningen Res Inst Pharm, Groningen, Netherlands.
C3 Russian Academy of Sciences; Tomsk National Research Medical Center;
   Mental Health Research Institute, Tomsk; Siberian State Medical
   University; Siberian State Medical University; University of Groningen
RP Loonen, AJM (corresponding author), Univ Groningen, PharmacoTherapy Epidemiol & Econ, Groningen Res Inst Pharm, Groningen, Netherlands.
EM a.j.m.loonen@rug.nl
RI Ivanova, Svetlana/C-5333-2012; Mednova, Irina/I-9584-2017; Semke,
   Arkady/GPS-6258-2022; Loonen, Anton/X-3129-2019; Bokhan,
   Nikolay/P-1720-2014; Boiko, Anastasiia/A-9465-2016; Kornetova,
   Elena/R-6811-2016
OI Loonen, Anton J.M./0000-0003-4942-6195; Bokhan,
   Nikolay/0000-0002-1052-855X; Boiko, Anastasiia/0000-0002-2955-9057;
   Kornetova, Elena/0000-0002-5179-9727
FU Russian Science Foundation [18-15-00011]; Russian Science Foundation
   [18-15-00011] Funding Source: Russian Science Foundation
FX This work was supported by the Russian Science Foundation, grant
   #18-15-00011.
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NR 44
TC 15
Z9 15
U1 0
U2 10
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
EI 1178-2021
J9 NEUROPSYCH DIS TREAT
JI Neuropsychiatr. Dis. Treat.
PY 2020
VL 16
BP 1051
EP 1058
DI 10.2147/NDT.S247161
PG 8
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Psychiatry
GA LF4NM
UT WOS:000527396400001
PM 32368067
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Bergqvist, A
   Karlsson, M
   Foldemo, A
   Wärdig, R
   Hultsjö, S
AF Bergqvist, Anette
   Karlsson, Maria
   Foldemo, Anniqa
   Wardig, Rikard
   Hultsjo, Sally
TI Preventing the Development of Metabolic Syndrome in People with
   Psychotic Disorders-Difficult, but Possible: Experiences of Staff
   Working in Psychosis Outpatient Care in Sweden
SO ISSUES IN MENTAL HEALTH NURSING
LA English
DT Article
ID SERIOUS MENTAL-ILLNESS; PHYSICAL HEALTH-CARE; WEIGHT-GAIN;
   SCHIZOPHRENIA; NEEDS; PERCEPTIONS; NURSES; INTERVENTION; INDIVIDUALS;
   ADULTS
AB The aim of this study was to explore mental health staffs' experiences of assisting people with psychotic disorders to implement lifestyle changes in an effort to prevent metabolic syndrome. Qualitative interviews were conducted with 12 health care professionals working in psychosis outpatient care in Sweden. Data were analysed using a qualitative content analysis. The results illustrate that implementation of lifestyle changes among people with psychotic disorders was experienced as difficult, but possible. The greatest obstacles experienced in this work were difficulties due to the reduction of cognitive functions associated with the disease. Guidelines available to staff in order to help them identify and prevent physical health problems in the group were not always followed and the content was not always relevant. Staff further described feelings of uncertainty about having to motivate people to take anti-psychotic medication while simultaneously being aware of the risks of metabolic deviations. Nursing interventions focusing on organising daily routines before conducting a more active prevention of metabolic syndrome, including information and practical support, were experienced as necessary. The importance of healthy eating and physical activity needs to be communicated in such a way that it is adjusted to the person's cognitive ability, and should be repeated over time, both verbally and in writing. Such efforts, in combination with empathic and seriously committed community-based social support, were experienced as having the best effect over time. Permanent lifestyle changes were experienced as having to be carried out on the patient's terms and in his or her home environment.
C1 [Bergqvist, Anette; Karlsson, Maria] Cty Hosp Ryhov, Dept Psychiat, S-55185 Jonkoping, Sweden.
   [Foldemo, Anniqa; Wardig, Rikard] Linkopings Univ, Dept Med & Hlth Sci, Linkoping, Sweden.
   [Hultsjo, Sally] Cty Hosp Ryhov, Dept Psychiat, Jonkping, Sweden.
C3 Linkoping University
RP Karlsson, M (corresponding author), Cty Hosp Ryhov, Psychiat Clin, Psychiat Emergency Unit, S-55185 Jonkoping, Sweden.
EM maria.u.karlsson@lj.se
OI Foldemo, Anniqa/0000-0003-4311-0739
FU Futurum; Psychiatric Clinic, County Hospital, Ryhov, Jonkoping;
   Department of Medical and Health Science, Linkoping University
FX This study was performed with grants from Futurum; the Psychiatric
   Clinic, County Hospital, Ryhov, Jonkoping; and Department of Medical and
   Health Science, Linkoping University.
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NR 58
TC 15
Z9 18
U1 0
U2 7
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 0161-2840
EI 1096-4673
J9 ISSUES MENT HEALTH N
JI Issues Ment. Health Nurs.
PD MAY
PY 2013
VL 34
IS 5
BP 350
EP 358
DI 10.3109/01612840.2013.771234
PG 9
WC Nursing; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Psychiatry
GA V38TR
UT WOS:000209366200008
PM 23663022
DA 2025-06-11
ER

PT J
AU Kim, S
   Joe, Y
   Jeong, SO
   Zheng, M
   Back, SH
   Park, SW
   Ryter, SW
   Chung, HT
AF Kim, Sena
   Joe, Yeonsoo
   Jeong, Sun Oh
   Zheng, Min
   Back, Sung Hoon
   Park, Sang Won
   Ryter, Stefan W.
   Chung, Hun Taeg
TI Endoplasmic reticulum stress is sufficient for the induction of IL-1β
   production via activation of the NF-κB and inflammasome pathways
SO INNATE IMMUNITY
LA English
DT Article
DE ER stress; reactive oxygen species; inflammasome; heme oxygenase-1;
   carbon monoxide
ID UNFOLDED PROTEIN RESPONSE; UP-REGULATED PROTEIN-1; ER STRESS; NLRP3
   INFLAMMASOME; OXIDATIVE STRESS; LIVER-CELLS; THIOREDOXIN; MECHANISMS;
   APOPTOSIS; CALCIUM
AB The mechanisms underlying pathophysiological states such as metabolic syndrome and obesity include endoplasmic reticulum (ER) stress and aberrant inflammatory responses. ER stress results from the accumulation of misfolded proteins during stress conditions. However, the precise mechanisms by which ER stress modulates inflammation remain incompletely understood. In this study, we hypothesized that ER stress alone could represent a sufficient signal for the modulation of inflammasome-dependent cytokine responses. We found that several ER stress-inducing chemicals and the free fatty acid palmitate can trigger IL-1 secretion in various cell types, including monocytic leukemia cells, primary macrophages and differentiated adipocytes. We show that ER stress primes cells for the expression of pro-IL-1 via NF-B activation and promotes IL-1 secretion. Enhanced IL-1 secretion depended on the activation of the NLRP3 inflammasome through a mechanism involving reactive oxygen species formation and activation of thioredoxin-interacting protein. Chemical chaperone treatment and the pharmacological application of carbon monoxide inhibited IL-1 secretion in response to ER stress. Our results provide a mechanistic link between ER stress and the regulation of inflammation, and suggest that modulation of ER stress may provide a therapeutic opportunity to block progression of low grade chronic inflammation to metabolic syndrome.
C1 [Kim, Sena; Joe, Yeonsoo; Jeong, Sun Oh; Zheng, Min; Back, Sung Hoon; Chung, Hun Taeg] Univ Ulsan, Sch Biol Sci, Ulsan 680749, South Korea.
   [Zheng, Min] YanBian Univ, Dept Thorac & Cardiovasc Surg, Affiliated Hosp, Yanji, Peoples R China.
   [Park, Sang Won] Gyeongsang Natl Univ, Sch Med, Dept Pharmacol, Jinju, South Korea.
   [Ryter, Stefan W.] Harvard Univ, Brigham & Womens Hosp, Sch Med, Boston, MA 02115 USA.
C3 University of Ulsan; Yanbian University; Gyeongsang National University;
   Harvard University; Harvard University Medical Affiliates; Brigham &
   Women's Hospital; Harvard Medical School
RP Chung, HT (corresponding author), Univ Ulsan, Sch Biol Sci, Ulsan 680749, South Korea.
EM chung@ulsan.ac.kr
RI Kim, You Sun/B-2881-2015
OI Kim, Sena/0000-0002-6930-2416
FU Bio & Medical Technology Development Program of the National Research
   Foundation (NRF) - Korean government (MEST) [2012M3A9C3048687]
FX This study was supported by the Bio & Medical Technology Development
   Program of the National Research Foundation (NRF) funded by the Korean
   government (MEST) (2012M3A9C3048687).
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NR 58
TC 106
Z9 120
U1 0
U2 17
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1753-4259
EI 1753-4267
J9 INNATE IMMUN-LONDON
JI Innate Immun.
PD NOV
PY 2014
VL 20
IS 8
BP 799
EP 815
DI 10.1177/1753425913508593
PG 17
WC Biochemistry & Molecular Biology; Immunology; Medicine, Research &
   Experimental; Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Immunology; Research & Experimental
   Medicine; Microbiology
GA AR8EB
UT WOS:000343807400002
PM 24217221
DA 2025-06-11
ER

PT J
AU Grenier-Larouche, T
   Galinier, A
   Casteilla, L
   Carpentier, AC
   Tchernof, A
AF Grenier-Larouche, Thomas
   Galinier, Anne
   Casteilla, Louis
   Carpentier, Andre C.
   Tchernof, Andre
TI Omental adipocyte hypertrophy relates to coenzyme Q10 redox state and
   lipid peroxidation in obese women
SO JOURNAL OF LIPID RESEARCH
LA English
DT Article
DE adipose tissue; obesity; adipocytes; antioxidant; mitochondria;
   ubiquinol; ubiquinone; body fat distribution; cardiometabolic risk
   factors
ID INSULIN-RESISTANCE; OXIDATIVE STRESS; RESPIRATORY-CHAIN;
   SKELETAL-MUSCLE; Q(10); LIPOPROTEIN; CELLS
AB Occurrence of oxidative stress in white adipose tissues contributes to its dysfunction and the development of obesity-related metabolic complications. Coenzyme Q10 (CoQ10) is the single lipophilic antioxidant synthesized in humans and is essential for electron transport during mitochondrial respiration. To understand the role of CoQ10 in adipose tissue physiology and dysfunction, the abundance of the oxidized and reduced (CoQ10(red)) isoforms of the CoQ10 were quantified in subcutaneous and omental adipose tissues of women covering the full range of BMI (from 21.5 to 53.2 kg/m(2)). Lean women displayed regional variations of CoQ10 redox state between the omental and subcutaneous depot, despite similar total content. Obese women had reduced CoQ10(red) concentrations in the omental depot, leading to increased CoQ10 redox state and higher levels of lipid hydroperoxide. Women with low omental CoQ10 content had greater visceral and subcutaneous adiposity, increased omental adipocyte diameter, and higher circulating interleukin-6 and C-reactive protein levels and were more insulin resistant. The associations between abdominal obesity-related cardiometabolic risk factors and CoQ10 content in the omental depot were abolished after adjustment for omental adipocyte diameter. This study shows that hypertrophic remodeling of visceral fat closely relates to depletion of CoQ10, lipid peroxidation, and inflammation.
C1 [Grenier-Larouche, Thomas; Tchernof, Andre] Ctr Hosp Univ Quebec, Endocrinol & Nephrol Axis, Quebec City, PQ, Canada.
   [Grenier-Larouche, Thomas; Carpentier, Andre C.] Univ Sherbrooke, Dept Med, Div Endocrinol, Quebec City, PQ, Canada.
   [Galinier, Anne; Casteilla, Louis] CNRS, UMR STROMALab 5273, Toulouse, France.
   [Galinier, Anne; Casteilla, Louis] UPS, Univ Toulouse, Toulouse, France.
   [Galinier, Anne; Casteilla, Louis] Fac Med Toulouse, INSERM, F-31073 Toulouse, France.
   [Galinier, Anne; Casteilla, Louis] EFS Pyrenees Mediterranee, Toulouse, France.
C3 Laval University; Laval University Hospital; University of Sherbrooke;
   Centre National de la Recherche Scientifique (CNRS); Universite de
   Toulouse; Universite Toulouse III - Paul Sabatier; Institut National de
   la Sante et de la Recherche Medicale (Inserm); Universite de Toulouse;
   Universite Toulouse III - Paul Sabatier
RP Tchernof, A (corresponding author), Ctr Hosp Univ Quebec, Endocrinol & Nephrol Axis, Quebec City, PQ, Canada.
EM andre.tchernof@crchul.ulaval.ca
OI Galinier, Anne/0000-0003-2454-5681; Casteilla,
   Louis/0000-0001-9647-3248; Tchernof, Andre/0000-0002-2587-1000
FU Canadian Institutes of Health Research, Institute of Gender and Health
   [MOP-64182]
FX This work was supported by operating funds from the Canadian Institutes
   of Health Research, Institute of Gender and Health (MOP-64182) (A.T.).
   A. Tchernof is codirector of a Research Chair in Bariatric and Metabolic
   Surgery. A. C. Carpentier is the director of the CIHR-GSK Chair in
   diabetes. The authors have declared no conflict of interest exists
   related to the content of this article.
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NR 24
TC 13
Z9 15
U1 0
U2 6
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0022-2275
EI 1539-7262
J9 J LIPID RES
JI J. Lipid Res.
PD OCT
PY 2015
VL 56
IS 10
BP 1985
EP 1992
DI 10.1194/jlr.P058578
PG 8
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA CS1RV
UT WOS:000361846300012
PM 26239051
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Fleet, SE
   Lefkowitch, JH
   Lavine, JE
AF Fleet, Sarah E.
   Lefkowitch, Jay H.
   Lavine, Joel E.
TI Current Concepts in Pediatric Nonalcoholic Fatty Liver Disease
SO GASTROENTEROLOGY CLINICS OF NORTH AMERICA
LA English
DT Article
DE Steatohepatitis; NASH; Obesity; Metabolic syndrome; Histopathology
ID STRESS-RELATED PARAMETERS; STELLATE CELL ACTIVATION; HEPATIC STEATOSIS;
   OXIDATIVE STRESS; OBESE CHILDREN; RISK-FACTORS;
   HEPATOCELLULAR-CARCINOMA; ALANINE AMINOTRANSFERASE; INSULIN-RESISTANCE;
   METABOLIC SYNDROME
AB Nonalcoholic fatty liver disease (NAFLD) represents a spectrum of disease. Its increasing prevalence is a direct result of historically high rates of obesity. Hepatocyte lipid accumulation is the first step in a cascade of metabolic and inflammatory events thought to precipitate NAFLD. Histologic findings provide insight into these events. Lifestyle modification remains the primary therapy in children. Current recommendations include vitamin E treatment in those with biopsy-proven NASH. Trials of novel drugs are ongoing in adults. As efficacy/safety are established, these therapies may be tenable for use in children. At the current time, biopsy-driven histology endpoints are necessary to establish whether future therapies can improve pediatric or adult-type NASH in children.
C1 [Fleet, Sarah E.] Columbia Univ, Med Ctr, Div Pediat Gastroenterol Hepatol & Nutr, 622 West 168th St,PH17-119, New York, NY 10032 USA.
   [Lefkowitch, Jay H.] Columbia Univ, Med Ctr, Dept Pathol, 630 West 168th St,PH 15W 1574, New York, NY 10032 USA.
   [Lavine, Joel E.] Columbia Univ, Med Ctr, Div Pediat Gastroenterol Hepatol & Nutr, 622 West 168th St,PH17-105F, New York, NY 10032 USA.
C3 Columbia University; Columbia University; Columbia University
RP Lavine, JE (corresponding author), Columbia Univ, Med Ctr, Div Pediat Gastroenterol Hepatol & Nutr, 622 West 168th St,PH17-105F, New York, NY 10032 USA.
EM jl3553@cumc.columbia.edu
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NR 78
TC 15
Z9 17
U1 0
U2 8
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0889-8553
EI 1558-1942
J9 GASTROENTEROL CLIN N
JI Gastroenterol. Clin. North Am.
PD JUN
PY 2017
VL 46
IS 2
BP 217
EP +
DI 10.1016/j.gtc.2017.01.002
PG 16
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA EX2CU
UT WOS:000403033900004
PM 28506362
DA 2025-06-11
ER

PT J
AU Mazidi, M
   Cicero, AF
   Kengne, AP
   Banach, M
AF Mazidi, Mohsen
   Cicero, Arrigo F.
   Kengne, Andre Pascal
   Banach, Maciej
TI Association Between Plasma Trans-Fatty Acid Concentrations and
   Measures of Glucose Homeostasis and Cardiovascular Risk Factors in
   Adults in NHANES 1999-2000
SO ANGIOLOGY
LA English
DT Article
DE cardiometabolic factors; glucose homeostasis; trans-fatty acids;
   insulin; National Health and Nutrition Examination Survey
ID INSULIN SENSITIVITY; METABOLIC SYNDROME; PALMITOLEIC ACID; OXIDATIVE
   STRESS; TELOMERE LENGTH; NATIONAL-HEALTH; DIETARY-INTAKE; WHOLE-BLOOD;
   CONSUMPTION; INFLAMMATION
AB There is limited evidence on the association between plasma trans-fatty acids (TFAs) and cardiometabolic risk factors. Therefore, we examined the association between plasma TFA concentrations and glucose homeostasis and cardiovascular (CV) risk factors in adult Americans from the 1999 to 2000 National Health and Nutrition Examination Survey participants. Derivatized TFAs were separated by capillary gas chromatography. Of the 1678 participants, 46.5% were men. The mean age was 50.5 years overall, with no significant difference between men and women (P = .101). In age-, sex- and race-adjusted analyses, mean waist circumference, fat-free mass, fat mass, C-peptide, insulin, hemoglobin A(1c) (HbA(1c)), homeostatic model assessment of insulin resistance (HOMA-IR), serum triglycerides (TGs), and total cholesterol (TC) increased across increasing quarters of TFAs (for all P < .001), while mean serum high-density lipoprotein cholesterol decreased across increasing quarters of plasma TFAs (P < .001). In multivariable adjusted linear regressions, there remained significant positive associations between all plasma TFAs and body mass index, waist circumference, fat-free mass, fat mass, C-peptide, insulin, fasting blood glucose, HOMA-IR, HbA(1c), TGs, low-density lipoprotein cholesterol, and TC (P < .001). In conclusion, our findings support a possible association between plasma TFAs concentrations and measures of glucose homeostasis and several CV risk factors.
C1 [Mazidi, Mohsen] Chinese Acad Sci, Inst Genet & Dev Biol, Key State Lab Mol Dev Biol, Beijing 100101, Peoples R China.
   [Mazidi, Mohsen] Univ Chinese Acad Sci, Inst Genet & Dev Biol, Int Coll, Beijing, Peoples R China.
   [Cicero, Arrigo F.] Alma Mater Studiorum Atherosclerosis & Metab Univ, Dis Res Ctr, Med & Surg Dept, Bologna, Italy.
   [Kengne, Andre Pascal] South African Med Res Council, Noncommunicable Dis Res Unit, Cape Town, South Africa.
   [Kengne, Andre Pascal] Univ Cape Town, Cape Town, South Africa.
   [Banach, Maciej] Med Univ Lodz, Dept Hypertens, Chair Nephrol & Hypertens, Lodz, Poland.
   [Banach, Maciej] Polish Mothers Mem Hosp, Res Inst, Lodz, Poland.
   [Banach, Maciej] Univ Zielona Gora, Cardiovasc Res Ctr, Zielona Gora, Poland.
C3 Chinese Academy of Sciences; Institute of Genetics & Developmental
   Biology, CAS; Chinese Academy of Sciences; University of Chinese Academy
   of Sciences, CAS; Institute of Genetics & Developmental Biology, CAS;
   South African Medical Research Council; University of Cape Town; Medical
   University Lodz; Polish Mother's Memorial Hospital - Research Institute;
   University of Zielona Gora
RP Mazidi, M (corresponding author), Chinese Acad Sci, Inst Genet & Dev Biol, Key State Lab Mol Dev Biol, Beijing 100101, Peoples R China.
EM moshen@genetics.ac.cn
RI Linn, Shai/N-3079-2019; Kengne, Andre/ABB-3696-2020; Cicero,
   Arrigo/H-8244-2019; Banach, Maciej/A-1271-2009
OI Kengne, Andre Pascal/0000-0002-5183-131X; Banach,
   Maciej/0000-0001-6690-6874; Cicero, Arrigo Francesco
   Giuseppe/0000-0002-4367-3884
FU TWAS studentship of the Chinese Academy of Sciences
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: MM was
   supported by a TWAS studentship of the Chinese Academy of Sciences.
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NR 50
TC 5
Z9 5
U1 0
U2 5
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0003-3197
EI 1940-1574
J9 ANGIOLOGY
JI Angiology
PD AUG
PY 2018
VL 69
IS 7
BP 630
EP 637
DI 10.1177/0003319717745987
PG 8
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA GM9GG
UT WOS:000438553800010
PM 29241351
DA 2025-06-11
ER

PT J
AU Forsberg, KA
   Björkman, T
   Sandman, PO
   Sandlund, M
AF Forsberg, Karl Anton
   Bjorkman, Tommy
   Sandman, Per Olof
   Sandlund, Mikael
TI Physical healtha cluster randomized controlled lifestyle intervention
   among persons with a psychiatric disability and their staff
SO NORDIC JOURNAL OF PSYCHIATRY
LA English
DT Article
DE Community care; Health education; Mental health; Metabolic syndrome;
   Randomized controlled trial
ID MENTAL-ILLNESS; SOCIOECONOMIC-STATUS; PERCEIVED EXERTION; SCHIZOPHRENIA;
   MORTALITY; SMOKING; PEOPLE; RISK; INDIVIDUALS; RELIABILITY
AB The objective was to explore the impact on physical health of a lifestyle programme among persons with psychiatric disabilities, and their caregivers. Their satisfaction with the intervention was also assessed. Somatic comorbidity and an increased mortality related to the lifestyle among persons with psychiatric disabilities are well known. Few randomized controlled trials have been aimed specifically at lifestyle issues among persons with a psychiatric disability. This trial includes clients with psychiatric disabilities living in supported housing and their staff. Forty-one persons with a DSM-?V diagnosis of severe mental illness from psychiatric disability from 10 supported housing facilities and 41 of their caregivers participated in this 12-month study during 2005-2006 in Sweden. The supported housing facilities with residents and staff were randomly assigned to either a health intervention programme or a control programme with an aesthetic content. The presence of metabolic syndrome and changes in the mean of physiological parameters such as Hba1c, P-glucose, P-insulin, lipids, blood pressure, physical working capacity, body mass index, Heart Score were investigated and participants' satisfaction assessed. There was a significant reduction in the mean of metabolic syndrome criteria in the intervention group compared with the control group at the follow-up. The participants expressed satisfaction with the programme. The results indicate that health interventions on lifestyle issues when involving carers are appreciated, feasible and could be successful in reducing some health-related risk factors among persons with psychiatric disabilities.
C1 [Forsberg, Karl Anton; Sandman, Per Olof] Umea Univ, Dept Nursing, SE-90187 Umea, Sweden.
   [Forsberg, Karl Anton] Swedish Inst Hlth Sci, Vardal Inst, SE-22100 Lund, Sweden.
   [Bjorkman, Tommy] Lund Univ, Dept Hlth, Inst Hlth Sci, SE-22100 Lund, Sweden.
   [Sandlund, Mikael] Umea Univ, Dept Clin Sci Psychiat, SE-90187 Umea, Sweden.
C3 Umea University; Lund University; Umea University
RP Forsberg, KA (corresponding author), Skelleftea Hosp, Psychiat Clin, SE-93186 Skelleftea, Sweden.
EM karlanton.forsberg@vll.se
FU Vasterbotten County Council; Swedish Institute for Health Sciences;
   Swedish Council for Working Life and Social Research; Foundation of
   Medical Research in Skelleftea
FX We thank the residents and their carers for their participation and the
   Swedish Inheritance Found, The Swedish Sports Confederation, Skelleftea
   Gym-och Atletforening and ABF, (Workers Educational Association) in
   Skelleftea for the co-operation in their project Livsteget. The study
   was supported by grants from The Vasterbotten County Council, The
   Swedish Institute for Health Sciences, The Swedish Council for Working
   Life and Social Research, Stiftelsen J C Kempes Minnes Stipendiefond and
   The Foundation of Medical Research in Skelleftea. We also thank
   Associate Professor Hans Stenlund, Umea University for the statistical
   review, research secretary Susanne Hallgren, Skelleftea psychiatric
   clinic for the administrative support, physiotherapist Maria Dahlkvist
   for conducting the test of working capacity (ISWT) and David Brunt,
   Senior Lecturer, Vaxjo University, for reviewing the English in the
   manuscript.
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NR 40
TC 55
Z9 55
U1 0
U2 10
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0803-9488
EI 1502-4725
J9 NORD J PSYCHIAT
JI Nord. J. Psychiatr.
PY 2008
VL 62
IS 6
BP 486
EP 495
AR PII 903466868
DI 10.1080/08039480801985179
PG 10
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 375BT
UT WOS:000261088600011
PM 18843564
DA 2025-06-11
ER

PT J
AU Gonzalez, A
   Simon, F
   Achiardi, O
   Vilos, C
   Cabrera, D
   Cabello-Verrugio, C
AF Gonzalez, Andrea
   Simon, Felipe
   Achiardi, Oscar
   Vilos, Cristian
   Cabrera, Daniel
   Cabello-Verrugio, Claudio
TI The Critical Role of Oxidative Stress in Sarcopenic Obesity
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Review
ID SKELETAL-MUSCLE ATROPHY; BODY-COMPOSITION; PHYSICAL FUNCTION;
   GROWTH-HORMONE; ADIPOSE-TISSUE; OLDER-ADULTS; STEM-CELLS; MOLECULAR
   INFLAMMATION; INSULIN-RESISTANCE; METABOLIC SYNDROME
AB Sarcopenic obesity (SO) is a combination of obesity and sarcopenia that primarily develops in older people. Patients with SO have high fat mass, low muscle mass, low muscle strength, and low physical function. SO relates to metabolic syndrome and an increased risk of morbimortality. The prevalence of SO varies because of lacking consensus criteria regarding its definition and the methodological difficulty in diagnosing sarcopenia and obesity. SO includes systemic alterations such as insulin resistance, increased proinflammatory cytokines, age-associated hormonal changes, and decreased physical activity at pathophysiological levels. Interestingly, these alterations are influenced by oxidative stress, which is a critical factor in altering muscle function and the generation of metabolic dysfunctions. Thus, oxidative stress in SO alters muscle mass, the signaling pathways that control it, satellite cell functions, and mitochondrial and endoplasmic reticulum activities. Considering this background, our objectives in this review are to describe SO as a highly prevalent condition and look at the role of oxidative stress in SO pathophysiology.</p>
C1 [Gonzalez, Andrea; Cabello-Verrugio, Claudio] Univ Andres Bello, Fac Life Sci, Lab Muscle Pathol Fragil & Aging, Dept Biol Sci, Santiago 8370146, Chile.
   [Gonzalez, Andrea; Simon, Felipe; Cabello-Verrugio, Claudio] Millennium Inst Immunol & Immunotherapy, Santiago 8370146, Chile.
   [Gonzalez, Andrea; Vilos, Cristian; Cabello-Verrugio, Claudio] Univ Santiago Chile, Ctr Dev Nano Sci & Nanotechnol CEDENNA, Santiago 8350709, Chile.
   [Simon, Felipe] Univ Chile, Millennium Nucl Ion Channel Associated Dis MiNICA, Santiago 8370146, Chile.
   [Simon, Felipe] Univ Andres Bello, Fac Life Sci, Dept Biol Sci, Lab Integrat Physiopathol, Santiago 8370146, Chile.
   [Achiardi, Oscar] Pontificia Univ Catolica Valparaiso, Fac Ciencias, Escuela Kinesiol, Valparaiso 2340025, Chile.
   [Vilos, Cristian] Univ Talca, Sch Med, Med Res Ctr, Lab Nanomed & Targeted Delivery, Talca 3460000, Chile.
   [Cabrera, Daniel] Pontificia Univ Catolica Chile, Fac Med, Dept Gastroenterol, Santiago 8330077, Chile.
   [Cabrera, Daniel] Univ Bernardo O Higgins, Fac Ciencias Med, Santiago 8370993, Chile.
C3 Universidad Andres Bello; Universidad de Santiago de Chile; Universidad
   de Chile; Universidad Andres Bello; Pontificia Universidad Catolica de
   Valparaiso; Universidad de Talca; Pontificia Universidad Catolica de
   Chile; Universidad  Bernardo O'Higgins
RP Cabello-Verrugio, C (corresponding author), Univ Andres Bello, Fac Life Sci, Lab Muscle Pathol Fragil & Aging, Dept Biol Sci, Santiago 8370146, Chile.; Cabello-Verrugio, C (corresponding author), Millennium Inst Immunol & Immunotherapy, Santiago 8370146, Chile.; Cabello-Verrugio, C (corresponding author), Univ Santiago Chile, Ctr Dev Nano Sci & Nanotechnol CEDENNA, Santiago 8350709, Chile.
EM ap.gonzalezrojas@gmail.com; fsimon@unab.cl; oscar.achiardi@pucv.cl;
   cristian.vilos@utalca.cl; dacabrer@uc.cl; claudio.cabello@unab.cl
RI Cabello-Verrugio, Claudio/AAD-1454-2020; CABRERA, DANIEL/AAR-5027-2020;
   Vilos, Cristian/KPA-9958-2024; Gonzalez, Andrea/HGU-7618-2022; Achiardi,
   Oscar/LFU-4968-2024
OI Simon, Felipe/0000-0002-2653-9798; Achiardi, Oscar/0000-0003-3623-0994;
   Cabello-Verrugio, Claudio/0000-0001-7273-2102; Gonzalez,
   Andrea/0000-0001-5003-7109; Vilos, Cristian/0000-0001-5619-3348;
   Cabrera, Daniel/0000-0001-9634-725X
FU National Fund for Science and Technological Development [FONDECYT
   1200944, 1201039, 1201147, 1211879]; Millennium Institute on Immunology
   and Immunotherapy [P09-016-F]; Basal Grant CEDENNA [AFB180001];
   Iniciativa Cientifica Milenio, ANID, Chile
FX The manuscript was supported by research grants from the National Fund
   for Science and Technological Development (FONDECYT 1200944 (CCV),
   1201039 (FS), 1201147 (CV), and 1211879 (DC)), Millennium Institute on
   Immunology and Immunotherapy (P09-016-F (CCV, FS)), and Basal Grant
   CEDENNA (AFB180001 (CCV, CV)). The Millennium Nucleus of Ion
   Channel-Associated Diseases (MiNICAD) is supported by the Iniciativa
   Cientifica Milenio, ANID, Chile. The online tool BioRender was used to
   elaborate the illustrations for this manuscript.
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NR 159
TC 36
Z9 37
U1 1
U2 28
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PD OCT 12
PY 2021
VL 2021
AR 4493817
DI 10.1155/2021/4493817
PG 14
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA WP5XE
UT WOS:000713203400002
PM 34676021
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Connolly, K
   Batacan, R Jr
   Jackson, D
   Vella, R
   Fenning, A
AF Connolly, Kylie
   Batacan Jr, Romeo
   Jackson, Douglas
   Vella, Rebecca
   Fenning, Andrew
TI Perindopril prevents development of obesity and hypertension in middle
   aged diet-induced obese rat models of metabolic syndrome
SO LIFE SCIENCES
LA English
DT Article
DE Perindopril; Metabolic syndrome; Diet-induced obesity; Cardiovascular
   disease; High-fat high-carbohydrate diet
ID CONVERTING ENZYME-INHIBITION; HIGH-FAT DIET; II-RECEPTOR BLOCKERS;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; ADIPOSE-TISSUE; BLOOD-PRESSURE;
   DIABETES-MELLITUS; GLUCOSE-TOLERANCE; FIXED COMBINATION
AB Aims: The therapeutic properties of anti-hypertensive medications that extend beyond blood pressure lowering have started to become important clinical targets in recent years. This study aimed to assess the cardioprotective effects of perindopril in attenuating complications associated with metabolic syndrome in diet induced obese rats.Main methods: Male Wistar-Kyoto (WKY) rats aged 16 weeks were fed either standard rat chow (SC) or given a high-fat-high-carbohydrate (HFHC) diet for 20 weeks. Perindopril treatment (1 mg/kg/day) was administered to a subset of WKY rats commencing at week 8 of the 20 week HFHC feeding period. Body weights, food, water and energy intakes, blood pressure, heart rate and glucose tolerance were measured throughout the treatment period. Oxidative stress and inflammatory markers, lipid levels, cardiac collagen deposition, vascular function, aortic and cardiac electrical function were examined after the treatment.Key findings: WKY rats developed metabolic syndrome after 20 weeks of HFHC feeding, evidenced by the presence of abdominal obesity, dyslipidaemia, glucose intolerance and hypertension. Perindopril treatment prevented the development of obesity and hypertension in WKY-HFHC. Perindopril improved blood lipid profiles in HFHC rats with decreases in LDL cholesterol, triglycerides and total cholesterol. Type I collagen levels were decreased in WKY-HFHC rats along with decreases in left ventricle mass. Perindopril treated rats also showed improved cardiac electrical function indicated by decreases in action potential at 90 % of repolarisation in WKYHFHC rats.Significance: These results show that perindopril has a profound effect on preventing the development of metabolic syndrome in animals fed a HFHC diet.
C1 [Connolly, Kylie; Batacan Jr, Romeo; Vella, Rebecca; Fenning, Andrew] Cent Queensland Univ, Sch Hlth Med & Appl Sci, Rockhampton, Qld 4701, Australia.
   [Jackson, Douglas] Australian Catholic Univ, 40 Edward St, North Sydney, NSW 2060, Australia.
C3 Central Queensland University; Australian Catholic University;
   Australian Catholic University - North Sydney Campus
RP Batacan, R Jr (corresponding author), Cent Queensland Univ, Sch Hlth Med & Appl Sci, Rockhampton, Qld 4701, Australia.
OI Jackson, Douglas/0000-0003-4835-0467
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   Weisinger RS, 2009, PHYSIOL BEHAV, V98, P192, DOI 10.1016/j.physbeh.2009.05.009
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NR 79
TC 3
Z9 3
U1 0
U2 9
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0024-3205
EI 1879-0631
J9 LIFE SCI
JI Life Sci.
PD FEB 1
PY 2023
VL 314
AR 121291
DI 10.1016/j.lfs.2022.121291
EA JAN 2023
PG 11
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA 8H2GE
UT WOS:000920852800001
PM 36535403
DA 2025-06-11
ER

PT J
AU Razali, NAA
   Rahman, TA
   Ismail, Z
   Kadir, SHSA
   Razak, SA
   Shariff, RER
   Shibraumalisi, NA
AF Razali, N. A. A.
   Rahman, T. Abdul
   Ismail, Z.
   Kadir, S. H. Sheikh Abdul
   Razak, S. Abdul
   Shariff, R. E. Raja
   Shibraumalisi, N. A.
TI Correlations of Estimated Serum Small Dense Low-Density Lipoprotein and
   Isoprostane with Metabolic Syndrome Criteria between Metabolic Syndrome
   and Non-Metabolic Syndrome Subjects in Selangor
SO IIUM MEDICAL JOURNAL MALAYSIA
LA English
DT Article
DE sdLDL-c; atherosclerosis; metabolic syndrome; isoprostane; JIS Criteria
ID VITAMIN-D; NUTRITIONAL-STATUS; CHILDREN; RICKETS; CALCIUM
AB INTRODUCTION: Metabolic syndrome (MetS) is a global healthcare burden associated with an increased risk of atherosclerosis (ATH). It is well understood that atherogenesis involves the complexity of inflammation, endothelial dysfunction, and oxidative stress. However, the relationship between atherogenic lipoproteins [small dense low-density lipoproteins (sdLDL)] and oxidative stress biomarkers [isoprostane (ISP)] among those with MetS has not been well established, which this study aims to understand. MATERIALS & METHODS: This cross-sectional study involved 67 MetS and 43 non-MetS subjects diagnosed by JIS criteria 2009. Demographic details and anthropometric measurements were recorded. Blood samples were collected to analyse direct LDL, sdLDL-c, and ISP. RESULTS: Mean serum sdLDL-c were significantly higher in MetS than non-MetS (1.14+0.44 mmol/L vs. 0.87 +/- 0.38 mmol/L, respectively, p=0.005). Similarly, mean serum ISP concentration was higher among MetS than non-MetS (884.40+602.69 ng/L vs. 657.89 +/- 616.42 ng/L, respectively, p=0.054). sdLDL-c was positively correlated with triglyceride (TG) in MetS (Spearman 0.552, p<.001), while HDL-c was positively correlated with sdLDL-c among non-MetS (Spearman 0.400, p<.005). CONCLUSION: This study emphasises the relationship between sdLDL-c and TG in MetS, emphasising the importance of closely monitoring and managing TG in this cohort to reduce the risk of ATH. It was noted that HDL-c showed a positive correlation with sdLDL-c among non-MetS. This discordant finding suggests that HDL-c may not be causally associated with cardiovascular benefits and that HDL-c subfractions may be a better approach to determining the cardioprotective effects of HDL-c.
C1 [Razali, N. A. A.; Rahman, T. Abdul; Ismail, Z.; Kadir, S. H. Sheikh Abdul; Razak, S. Abdul; Shariff, R. E. Raja] Univ Teknol MARA, Fac Med, Sungai Buloh, Selangor, Malaysia.
   [Rahman, T. Abdul; Razak, S. Abdul; Shariff, R. E. Raja; Shibraumalisi, N. A.] Univ Teknol MARA, Hosp Al Sultan Abdullah, Puncak Alam, Malaysia.
   [Rahman, T. Abdul] Univ Teknol MARA, Integrat Pharmacogen Inst iPROMISE, Puncak Alam, Malaysia.
   [Rahman, T. Abdul; Kadir, S. H. Sheikh Abdul] Univ Teknol MARA, Inst Pathol Lab & Forens Med I PPerForM, Sungai Buloh, Selangor, Malaysia.
C3 Universiti Teknologi MARA; Universiti Teknologi MARA; Universiti
   Teknologi MARA; Universiti Teknologi MARA
RP Shariff, RER (corresponding author), Univ Teknol MARA, Hosp Al Sultan Abdullah, Puncak Alam, Malaysia.
EM rajaezman@uitm.edu.my
RI Sheikh Abdul Kadir, Siti Hamimah/ABA-7769-2021; Abdul Razak,
   Suraya/KHC-5629-2024; SHARIFF, RAJA/A-3441-2019; Shibraumalisi,
   Nur/ADE-3911-2022
CR Chan CY, 2018, SAINS MALAYS, V47, P1801, DOI 10.17576/jsm-2018-4708-19
   Hamid Jan JM, 2016, ILSI ANN M ST PET FL
   Kovacs CS, 2008, AM J CLIN NUTR, V88, p520S, DOI 10.1093/ajcn/88.2.520S
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NR 11
TC 0
Z9 0
U1 0
U2 0
PU INT ISLAMIC UNIV MALAYSIA, KULLIYYAH MEDICINE
PI KUANTAN PAHAN
PA JALAN SULTAN AHMAD SHAH, KUANTAN PAHAN, 25200, MALAYSIA
SN 1823-4631
EI 2735-2285
J9 IIUM MED J MALAYSIA
JI IIUM Med. J. Malaysia
PD JUL
PY 2023
VL 22
IS 3
BP 114
EP 123
PG 10
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA Z0IY6
UT WOS:001109019100023
DA 2025-06-11
ER

PT J
AU da Silva, BR
   Radil, AI
   Collins, L
   Maeda, N
   Prado, CM
   Ferguson-Pell, M
   Klein, D
AF da Silva, Bruna R.
   Radil, Amanda I.
   Collins, Liam
   Maeda, Nathanial
   Prado, Carla M.
   Ferguson-Pell, Martin
   Klein, Doug
TI Study protocol for a single-arm pilot trial investigating the
   feasibility of a multimodal digital technology for managing metabolic
   syndrome in patients with chronic obstructive pulmonary disease
SO METHODS
LA English
DT Article
DE Internet-based intervention; Digital platform; Lifestyle intervention;
   Dietary intake; Physical activity; Mindfulness; Primary care; Metabolic
   syndrome; Chronic obstructive pulmonary disease
ID SELF-MANAGEMENT; PRIMARY-CARE; EXERCISE; FAT
AB Individuals diagnosed with Chronic Obstructive Pulmonary Disease (COPD) are exposed to an increased risk of metabolic syndrome (MetS), which negatively affects their health outcomes and quality of life. Lifestyle interventions have shown promise in managing MetS. This study outlines the protocol for a web-based multimodal self-care program, Digital Metabolic Rehabilitation, for managing MetS in patients with COPD. The Digital Metabolic Rehabilitation is a single-arm pilot trial that integrates the Canadian Health Advanced by Nutrition and Graded Exercise (CHANGE) Program and a web-based wellness platform. The web-based wellness platform employed in this study is My Viva Plan (MVP)(R), which integrates a holistic, multicomponent approach to promote wellness. The intervention will primarily focus on lifestyle changes for patients with COPD. Over 6 months, participants will use the web-based wellness platform and engage in weekly online support group sessions. Fifty patients diagnosed with stage I-II COPD and MetS will participate. Blood tests, anthropometrics, body composition, physical function, muscle strength, physical activity, energy metabolism, quality of life and mental health will be assessed at baseline, 3, and 6 months. The Digital Metabolic Rehabilitation program aims to explore whether a multimodal integrative intervention delivered through a web-based wellness platform can be implemented by patients with COPD with MetS. By combining the expertise of the CHANGE Program with the digital delivery format, the intervention seeks to enhance self-monitoring and foster better self-management practices. The protocol outlines a novel and potentially impactful intervention for managing MetS in patients with COPD.
C1 [da Silva, Bruna R.; Prado, Carla M.] Univ Alberta, Li Ka Shing Ctr Hlth Innovat 2 021, Dept Agr Food & Nutr Sci, Edmonton, AB T6G 2E1, Canada.
   [Radil, Amanda I.; Collins, Liam; Klein, Doug] Univ Alberta, Dept Family Med, 6-10 Univ Terrace, Edmonton, AB T6G 2T4, Canada.
   [Maeda, Nathanial; Ferguson-Pell, Martin] Univ Alberta, Edmonton Clin Hlth Acad 2 545, Fac Rehabil Med, Edmonton, AB T6G2G3, Canada.
   [Maeda, Nathanial] My Viva Inc & Rev Wellness Inc, 3728 91 St NW, Edmonton, AB T6E5M3, Canada.
C3 University of Alberta; University of Alberta; University of Alberta
RP Klein, D (corresponding author), Univ Alberta, Dept Family Med, 6-10 Univ Terrace, Edmonton, AB T6G 2T4, Canada.
EM ramosdas@ualberta.ca; amanda.radil@ualberta.ca;
   liam.collins@ualberta.ca; nathanial@revivewellness.ca;
   carla.prado@ualberta.ca; martin.ferguson-pell@ualberta.ca;
   doug.klein@ualberta.ca
RI Prado, Carla/G-9365-2019; da Silva, Bruna/JNR-9840-2023
OI Prado, Carla/0000-0002-3609-5641
FU University Hospital Foundation through the Alberta Boehringer Ingelheim
   Collaboration [UA290413]; Mitacs Accelerate program [IT29509]; My Viva
   Inc; Canada Research Chair Program; Canadian Foundation for Innovation
   (John R. Evans Leaders Fund) [34115]
FX This study is supported by University Hospital Foundation through the
   Alberta Boehringer Ingelheim Collaboration (UA290413) and Mitacs
   Accelerate program (IT29509), a collaborative funding program with the
   company (My Viva Inc) that partially funded a trainee's salary to BRS.
   My Viva Inc designed the online support group sessions. The funders will
   not be involved in data analysis, interpretation, or manuscript
   preparation and publication. CMP acknowledges partial funding from
   Canada Research Chair Program. This research is partially funded by the
   Canadian Foundation for Innovation (John R. Evans Leaders Fund, grant
   number: 34115).
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NR 53
TC 1
Z9 1
U1 0
U2 0
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 1046-2023
EI 1095-9130
J9 METHODS
JI Methods
PD NOV
PY 2024
VL 231
BP 195
EP 203
DI 10.1016/j.ymeth.2024.10.003
EA OCT 2024
PG 9
WC Biochemical Research Methods; Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA J3P0B
UT WOS:001336202500001
PM 39389402
OA hybrid
DA 2025-06-11
ER

PT J
AU Lindenmayer, JP
   Khan, A
   Kaushik, S
   Thanju, A
   Praveen, R
   Hoffman, L
   Cherath, L
   Valdez, G
   Wance, D
AF Lindenmayer, Jean Pierre
   Khan, Anzalee
   Kaushik, Saurabh
   Thanju, Amod
   Praveen, Rajalakshmi
   Hoffman, Lisa
   Cherath, Lata
   Valdez, Gladys
   Wance, Deborah
TI Relationship between metabolic syndrome and cognition in patients with
   schizophrenia
SO SCHIZOPHRENIA RESEARCH
LA English
DT Article
DE Schizophrenia; Metabolic syndrome; Cognition; Treatment of metabolic
   dysfunctions
ID CLINICAL ANTIPSYCHOTIC TRIALS; IMPAIRED FASTING GLUCOSE;
   MINI-MENTAL-STATE; BRAIN COMPLICATIONS; MEMORY IMPAIRMENTS;
   DIABETES-MELLITUS; RISK; PREVALENCE; HYPERTENSION; PERFORMANCE
AB Background: The metabolic syndrome (MetS) and cognitive impairments are common in schizophrenia. Both are associated with poor outcomes, which have received increasing medical and mental health attention. Whether MetS is associated with impaired cognitive functions in schizophrenia has not been thoroughly addressed. The aim of this study was to compare the association between patients with and without MetS and its contributing components with neurocognitive performance. We hypothesized that patients with MetS would be associated with more impaired cognitive performance.
   Methods: 159 patients with schizophrenia or schizoaffective disorder, with available metabolic data were included in the study. Patients were classified as either having or not having MetS as defined by the NCEP Adult Panel-III criteria. All patients completed neurocognitive and metabolic tests.
   Results: Of the 159 patients, 43.34% had MetS. Patients without the MetS performed significantly better on tests measuring processing speed (p=0.050), attention/vigilance (p=0.040), working memory (p=0.041) and problem solving/reasoning (p=0.050) compared with those with MetS. Patients with MetS showed significantly lower cognitive domain scores. After Bonferroni correction greater waist circumference was associated with lower scores on attention/vigilance (beta=-0.551; p <=.0083), HDL was positively associated with scores on attention/vigilance (beta=0.900, p <=.0083) and higher triglycerides were associated with lower scores on attention/vigilance (beta=-1.004, p <=.0083).
   Conclusions: Schizophrenia patients with MetS showed significant cognitive impairments in three key cognitive domains. Aggressive medical treatment of the constituent components of MetS may provide the potential for important beneficial effects on patients' cognitive functioning. (C) 2012 Elsevier B.V. All rights reserved.
C1 [Lindenmayer, Jean Pierre] Manhattan Psychiat Ctr, Psychopharmacol Res Dept, Wards Isl, NY 10035 USA.
   [Lindenmayer, Jean Pierre; Kaushik, Saurabh; Cherath, Lata] NYU, New York, NY USA.
   [Lindenmayer, Jean Pierre; Kaushik, Saurabh; Thanju, Amod; Praveen, Rajalakshmi] Nathan S Kline Inst Psychiat Res, Orangeburg, NY 10962 USA.
   [Khan, Anzalee] ProPhase LLC, New York, NY USA.
C3 New York University; Nathan Kline Institute for Psychiatric Research
RP Lindenmayer, JP (corresponding author), Manhattan Psychiat Ctr, Psychopharmacol Res Dept, 600 E 125 St, Wards Isl, NY 10035 USA.
EM Lindenmayer@nki.rfmh.org
RI Kaushik, Saurabh/AAS-4182-2021
FU Lilly; Johnsons and Johnson; Otsuka; Sunovion; Amgen
FX J.P. Lindenmayer receives research support from Lilly, Johnsons and
   Johnson, Otsuka, Sunovion and Amgen. All other co-authors have no
   research support to disclose.
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NR 39
TC 83
Z9 87
U1 1
U2 16
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0920-9964
EI 1573-2509
J9 SCHIZOPHR RES
JI Schizophr. Res.
PD DEC
PY 2012
VL 142
IS 1-3
BP 171
EP 176
DI 10.1016/j.schres.2012.09.019
PG 6
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 039CR
UT WOS:000311220900026
PM 23106932
DA 2025-06-11
ER

PT J
AU Leibowitz, A
   Rehman, A
   Paradis, P
   Schiffrin, EL
AF Leibowitz, Avshalom
   Rehman, Asia
   Paradis, Pierre
   Schiffrin, Ernesto L.
TI Role of T Regulatory Lymphocytes in the Pathogenesis of High-Fructose
   Diet-Induced Metabolic Syndrome
SO HYPERTENSION
LA English
DT Article
DE inflammation; interleukin-10; oxidative stress; vascular remodeling
ID INSULIN-RESISTANCE; OXIDATIVE STRESS; BLOOD-PRESSURE; VASCULAR
   INFLAMMATION; ENDOTHELIAL DYSFUNCTION; ADIPONECTIN LEVELS; NITRIC-OXIDE;
   HYPERTENSION; CELLS; RATS
AB We recently showed that T regulatory lymphocytes (Treg), which are immune suppressors of inflammatory responses, play a role blunting the development of hypertension-induced injury. Treg are unchanged or decreased in children with metabolic syndrome, and therefore, their role in metabolic syndrome remains unclear. We hypothesized that Treg number or function would be depressed in a high-fructose diet-induced metabolic syndrome-like model in rats. Sprague-Dawley rats were fed normal chow or a high-fructose diet for 5 weeks. The high-fructose diet-induced a 3.8-fold increase in plasma triglycerides and a 14% reduction in high-density lipoprotein cholesterol (P<0.001). The high-fructose diet increased reactive oxygen species in aorta and periaortic adipose tissue 2.8-fold (P<0.05), and reduced nicotinamide adenine dinucleotide phosphate oxidase activity 1.9-fold in aorta, and 2.5-fold in the heart (P<0.05). It also increased plasma nitric oxide metabolite levels 6.4-fold (P<0.001). Western blots showed that the high-fructose diet increased >= 2.3-fold vascular and in platelet endothelial cell adhesion molecule 1 in aorta (P<0.01). It did not affect monocyte/macrophage aortic infiltration but caused a 2.4-fold increase in collagen deposition in the aortic media (P<0.01). No change in plasma interleukin-10 was detected. The percentage of spleen CD4(+)CD25(-) and Treg (CD4(+)CD25(high)) cells was unaltered by the high-fructose diet. However, cultured Treg from high-fructose diet-fed rats secreted 62% less interleukin-10 than control cells (P<0.05), suggesting a decreased Treg function, which could play a role in the development of cardiovascular complications of the metabolic syndrome.
C1 [Leibowitz, Avshalom; Rehman, Asia; Paradis, Pierre; Schiffrin, Ernesto L.] McGill Univ, Sir Mortimer B Davis Jewish Gen Hosp, Lady Davis Inst Med Res, Montreal, PQ, Canada.
   [Schiffrin, Ernesto L.] McGill Univ, Sir Mortimer B Davis Jewish Gen Hosp, Dept Med, Montreal, PQ, Canada.
C3 Jewish General Hospital - Montreal; McGill University; Lady Davis
   Institute; Jewish General Hospital - Montreal; McGill University
RP Schiffrin, EL (corresponding author), Sir Mortimer B Davis Jewish Hosp, Dept Med, B-127,3755 Cote Ste Catherine Rd, Montreal, PQ H3T 1E2, Canada.
EM ernesto.schiffrin@mcgill.ca
RI Schiffrin, Ernesto/AAB-9061-2019
OI Schiffrin, Ernesto/0000-0002-4502-2823
FU Canadian Institutes of Health Research [82790, 102606]; Canada Research
   Chair (CRC) on Hypertension and Vascular Research from the Canadian
   Institutes of Health Research/government of Canada CRC program; Canada
   Fund for Innovation
FX This work was funded by the Canadian Institutes of Health Research
   grants 82790 and 102606, a Canada Research Chair (CRC) on Hypertension
   and Vascular Research from the Canadian Institutes of Health
   Research/government of Canada CRC program, and by the Canada Fund for
   Innovation; all to Dr Schiffrin.
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NR 50
TC 30
Z9 35
U1 1
U2 7
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0194-911X
EI 1524-4563
J9 HYPERTENSION
JI Hypertension
PD JUN
PY 2013
VL 61
IS 6
BP 1316
EP +
DI 10.1161/HYPERTENSIONAHA.111.203521
PG 21
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 147JL
UT WOS:000319162800034
PM 23529169
OA Bronze
DA 2025-06-11
ER

PT J
AU Boke, O
   Aker, S
   Sarisoy, G
   Saricicek, EB
   Sahin, AR
AF Boke, Omer
   Aker, Servet
   Sarisoy, Gokhan
   Saricicek, Esin Boke
   Sahin, Ahmet Rifat
TI Prevalence of metabolic syndrome among inpatients with schizophrenia
SO INTERNATIONAL JOURNAL OF PSYCHIATRY IN MEDICINE
LA English
DT Article
DE schizophrenia; metabolic syndrome; mental hospital
ID CORONARY-HEART-DISEASE; INSULIN-RESISTANCE; RISK
AB Objective: Cardiovascular disease is one of the most prevalent factors responsible for excess mortality in schizophrenia. Metabolic syndrome (MetS) is associated with the development of coronary heart disease and diabetes mellitus. The aim in this cross-sectional study was to assess the prevalence of MetS in schizophrenic Turkish inpatients. Method The study was conducted from January 2006 to June 2006, and included 231 patients with schizophrenia. All participants were enrolled from inpatients attending the Samsun Mental Health Hospital psychiatry clinic. All subjects were aged between 18 and 65 and met the DSM IV criteria for schizophrenia. MetS was taken as central obesity (defined as waist circumference: men >= 94 cm, women 80 cm) and meeting >= 2 of the following abnormalities described by the International Diabetes Federation (IDF): a serum triglyceride level > 150 mg/dL, high-density lipoprotein (HDL) cholesterol < 40 mg/dL in men and < 50 mg/dL in women, blood pressure 130/85 nun Hg, and a fasting serum glucose level >= 100 mg/d/L. Results: The study group consisted of 174 male and 5 7 female patients. Mean age was 3 8.5 +/- 10.5 and mean duration of illness was 15.76 +/- 9.95 years. The overall prevalence of MetS diagnosed according to the IDF criteria was 32.0% (n = 74) and was higher in females (61.4%) than in males (22.4%; p = 0.0001). In logistic regression analysis the last step of the regression model was gender (B = 1.70, p = 0.0001, OR = 5.50, 95% CI = 2.90-10.45). Conclusion: This study shows that the prevalence of MetS in Turkish patients with schizophrenia is similar to that of the general population, but lower than in other reports regarding the schizophrenia population.
C1 [Boke, Omer; Aker, Servet; Sarisoy, Gokhan; Sahin, Ahmet Rifat] Ondokuz Mayis Univ, Sch Med, TR-55139 Kurupelit, Turkey.
C3 Ondokuz Mayis University
RP Boke, O (corresponding author), Ondokuz Mayis Univ, Sch Med, TR-55139 Kurupelit, Turkey.
RI Aker, Servet/A-7618-2019; SAHIN, AHMET RIFAT/C-6089-2019
OI SAHIN, AHMET RIFAT/0000-0002-6897-3891
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NR 27
TC 34
Z9 36
U1 0
U2 20
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0091-2174
EI 1541-3527
J9 INT J PSYCHIAT MED
JI Int. J. Psychiatr. Med.
PY 2008
VL 38
IS 1
BP 103
EP 112
DI 10.2190/PM.38.1.j
PG 10
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 326XX
UT WOS:000257694000010
PM 18624022
DA 2025-06-11
ER

PT J
AU Alagha, M
   Al-Alam, F
   Saroufine, K
   Elias, L
   Klaimi, M
   Nabbout, G
   Harb, F
   Azar, S
   Nahas, N
   Ghadieh, HE
AF Alagha, Michel
   Al-Alam, Firas
   Saroufine, Karmen
   Elias, Linda
   Klaimi, Mark
   Nabbout, Ghassan
   Harb, Frederic
   Azar, Sami
   Nahas, Nayla
   Ghadieh, Hilda E.
TI Binge Eating Disorder and Metabolic Syndrome: Shared Mechanisms and
   Clinical Implications
SO HEALTHCARE
LA English
DT Review
DE binge eating disorder; metabolic syndrome; obesity; genetic factors;
   behavioral factors; neurological factors; biological factors; food
   insecurity
ID NECROSIS-FACTOR-ALPHA; FOOD INSECURITY; CHILDHOOD EXPERIENCES;
   ATHEROSCLEROSIS RISK; ANOREXIA-NERVOSA; MENTAL-HEALTH; URIC-ACID;
   HIGH-FAT; OBESITY; INTERLEUKIN-18
AB Background: Binge eating disorder (BED) is characterized by episodes of uncontrollable eating, defined by the rapid consumption of large quantities of food over a short period. This condition is associated with a variety of psychological and non-psychological factors, including behavioral, biological, genetic, neurological, and pharmacological influences, all of which adversely affect patients' daily lives. BED is linked to numerous health consequences, such as obesity, atherosclerosis, diabetes, chronic pain, and hypertension. Although BED is not exclusive to individuals with obesity, it is more prevalent in this population, who also face a heightened risk of developing metabolic syndrome (MetS). The latter is a cluster of five risk factors-obesity, hyperlipidemia, hyperinsulinemia, hypertension, and hyperglycemia-that significantly increase the likelihood of chronic diseases. Methods: This narrative review synthesizes existing research to explore the association between BED and MetS, examining shared pathophysiological mechanisms and clinical implications. It also highlights the role of escalating food insecurity and ongoing political, economic, and health crises in the development of BED. Results: BED is significantly associated with MetS components, including hypertension, obesity, type 2 diabetes, and dyslipidemia, all contributing to increased morbidity and mortality. Beyond body weight, behavioral, genetic, biological, and neurological factors mediate this relationship. Conclusions: BED is strongly linked to MetS through shared behavioral, genetic, and biological pathways. Early detection, integrated management strategies, and further research are crucial to addressing the public health challenges posed by this association.
C1 [Alagha, Michel; Saroufine, Karmen; Elias, Linda; Nabbout, Ghassan; Harb, Frederic; Azar, Sami; Ghadieh, Hilda E.] Univ Balamand, Fac Med & Med Sci, Dept Biomed Sci, POB 100, Al Koura, Tripoli, Lebanon.
   [Al-Alam, Firas; Nahas, Nayla] Univ Balamand, Fac Arts & Sci, Dept Psychol, POB 100, Koura, Tripoli, Lebanon.
   [Klaimi, Mark] Univ Balamand, Fac Arts & Sci, Dept Biol, POB 100, Koura, Tripoli, Lebanon.
C3 University Balamand; University Balamand; University Balamand
RP Ghadieh, HE (corresponding author), Univ Balamand, Fac Med & Med Sci, Dept Biomed Sci, POB 100, Al Koura, Tripoli, Lebanon.
EM michel.alagha@std.balamand.edu.lb; firas.a.alam@fty.balamand.edu.lb;
   karmen.saroufine@std.balamand.edu.lb; linda.elias@std.balamand.edu.lb;
   mark.klaimi@std.balamand.edu.lb; ghassan.nabbout@fty.balamand.edu.lb;
   frederic.harb@balamand.edu.lb; sami.azar@balamand.edu.lb;
   nayla.nahas@balamand.edu.lb; hilda.ghadieh@balamand.edu.lb
RI Harb, Frederic/O-4587-2019
OI Nahas, Nayla/0000-0002-6418-3534; Ghadieh, Hilda E./0000-0002-7983-2090;
   Harb, Frederic/0000-0001-5882-1619
FU Faculty of Medicine and Medical Sciences at the University of Balamand
FX The publication of this review article was supported by the Faculty of
   Medicine and Medical Sciences at the University of Balamand, which
   covered the Article Processing Charges.
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NR 111
TC 0
Z9 0
U1 4
U2 4
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2227-9032
J9 HEALTHCARE-BASEL
JI Healthcare
PD MAR
PY 2025
VL 13
IS 5
AR 482
DI 10.3390/healthcare13050482
PG 19
WC Health Care Sciences & Services; Health Policy & Services
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services
GA Z9W9G
UT WOS:001442332200001
PM 40077044
OA gold
DA 2025-06-11
ER

PT J
AU Coates, D
   Woodford, P
   Higgins, O
   Grover, D
AF Coates, Dominiek
   Woodford, Patricia
   Higgins, Oliver
   Grover, Deborah
TI Evaluation of a general practitioner-led cardiometabolic clinic:
   Physical health profile andtreatment outcomes for clients on clozapine
SO INTERNATIONAL JOURNAL OF MENTAL HEALTH NURSING
LA English
DT Article
DE antipsychotic medication; clozapine; metabolic syndrome
ID METABOLIC SYNDROME; PEOPLE; MANAGEMENT; METFORMIN; MORTALITY; ILLNESS
AB The present study is a review of a cardiometabolic clinic for consumers taking clozapine. This clinic was recently established and co-located with the clozapine clinic at a regional hospital in New South Wales, Australia, to enhance engagement and improve the physical health outcomes of consumers taking antipsychotic medication. A descriptive analysis of clients' (n=73) information collected during routine care for the first 6months of the clinic's operation, from January 2016 to July 2016, was conducted. First-visit data were analysed to establish a client profile, consisting of weight, height, blood pressure, pulse, a range of blood measurements, smoking status, alcohol consumption, and eating and exercise habits. Data collected for clients who had three or more visits with the general practitioner (n=40) were analysed separately for outcomes. Two case studies are used to depict the service received and client profile. At the first appointment, the majority of clients had metabolic syndrome that was mostly left untreated; many of these clients were commenced on metformin. The outcomes are positive, and show that the majority of clients lost weight (82.5%) and had a reduction in body mass index (84.6%); nearly half (44.4%) had a reduction in waist circumference. The majority of clients self-reported increased physical activity (72.5%, n=29) and positive dietary changes (77.5%, n=31) since their first appointment. The model trialled by the cardiometabolic clinic integrated a specialist mental health and primary care service, and demonstrates success in engaging clients with severe mental illness in physical health care. Co-location is conceptualized as critical for positive patient outcomes and high levels of engagement.
C1 [Coates, Dominiek; Woodford, Patricia; Higgins, Oliver; Grover, Deborah] Cent Coast Local Hlth Dist, Cent Coast Mental Hlth, Gosford, NSW, Australia.
C3 Central Coast Local Health District
RP Coates, D (corresponding author), Gosford Hosp, Cent Coast Local Hlth Dist, Cent Coast Mental Hlth, Gosford, NSW 2250, Australia.
EM Dominiek.Coates@health.nsw.gov.au
RI Higgins, Oliver/ABD-9586-2021
OI Higgins, Oliver/0000-0001-6545-145X; Coates,
   Dominiek/0000-0002-4463-7615
FU Central Coast Partners in Recovery Consortium; Central Coast Partners in
   Recovery Consumer Advisory Committee
FX The authors thank the Central Coast Partners in Recovery Consortium and
   the Central Coast Partners in Recovery Consumer Advisory Committee for
   their interest and support with this project and the provision of the
   funding grant for the establishment of the clinic.
CR [Anonymous], PHCRIS POLICY ISSUE
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NR 33
TC 9
Z9 9
U1 0
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1445-8330
EI 1447-0349
J9 INT J MENT HEALTH NU
JI Int. J. Ment. Health Nurs.
PD FEB
PY 2018
VL 27
IS 1
BP 303
EP 310
DI 10.1111/inm.12321
PG 8
WC Nursing; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Psychiatry
GA FS3XF
UT WOS:000419717100030
PM 28233407
DA 2025-06-11
ER

PT J
AU Rovira-Llopis, S
   Díaz-Rúa, R
   Grau-del Valle, C
   Iannantuoni, F
   Abad-Jimenez, Z
   Bosch-Sierra, N
   Panadero-Romero, J
   Victor, VM
   Rocha, M
   Morillas, C
   Bañuls, C
AF Rovira-Llopis, Susana
   Diaz-Rua, Ruben
   Grau-del Valle, Carmen
   Iannantuoni, Francesca
   Abad-Jimenez, Zaida
   Bosch-Sierra, Neus
   Panadero-Romero, Joaquin
   Victor, Victor M.
   Rocha, Milagros
   Morillas, Carlos
   Banuls, Celia
TI Characterization of Differentially Expressed Circulating miRNAs in
   Metabolically Healthy versus Unhealthy Obesity
SO BIOMEDICINES
LA English
DT Article
DE obesity; metabolic syndrome; microRNAs; insulin resistance; atherogenic
   dyslipidaemia; oxidative stress
ID INSULIN SENSITIVITY; OXIDATIVE STRESS; ADIPOSE-TISSUE; MICRORNA;
   GENETICS; TARGET; RESISTANCE
AB Obese individuals without metabolic comorbidities are categorized as metabolically healthy obese (MHO). MicroRNAs (miRNAs) may be implicated in MHO. This cross-sectional study explores the link between circulating miRNAs and the main components of metabolic syndrome (MetS) in the context of obesity. We also examine oxidative stress biomarkers in MHO vs. metabolically unhealthy obesity (MUO). We analysed 3536 serum miRNAs in 20 middle-aged obese individuals: 10 MHO and 10 MUO. A total of 159 miRNAs were differentially expressed, of which, 72 miRNAs (45.2%) were higher and 87 miRNAs (54.7%) were lower in the MUO group. In addition, miRNAs related to insulin signalling and lipid metabolism pathways were upregulated in the MUO group. Among these miRNAs, hsa-miR-6796-5p and hsa-miR-4697-3p, which regulate oxidative stress, showed significant correlations with glucose, triglycerides, HbA1c and HDLc. Our results provide evidence of a pattern of differentially expressed miRNAs in obesity according to MetS, and identify those related to insulin resistance and lipid metabolism pathways.
C1 [Rovira-Llopis, Susana; Diaz-Rua, Ruben; Grau-del Valle, Carmen; Iannantuoni, Francesca; Abad-Jimenez, Zaida; Bosch-Sierra, Neus; Victor, Victor M.; Rocha, Milagros; Morillas, Carlos; Banuls, Celia] Fdn Promot Hlth & Biomed Res Valencian Reg FISABI, Univ Hosp Doctor Peset, Serv Endocrinol, Valencia 46017, Spain.
   [Panadero-Romero, Joaquin] La Fe Hlth Res Inst, Genom Unit, Valencia 46026, Spain.
   [Victor, Victor M.; Rocha, Milagros] Univ Valencia, CIBERehd Dept Pharmacol & Physiol, Valencia 46015, Spain.
   [Victor, Victor M.] Univ Valencia, Dept Physiol, Valencia 46015, Spain.
   [Morillas, Carlos] Univ Valencia, Dept Med, Valencia 46015, Spain.
C3 CIBER - Centro de Investigacion Biomedica en Red; CIBEREHD; University
   of Valencia; University of Valencia; University of Valencia
RP Bañuls, C (corresponding author), Fdn Promot Hlth & Biomed Res Valencian Reg FISABI, Univ Hosp Doctor Peset, Serv Endocrinol, Valencia 46017, Spain.
EM srovirallopis@gmail.com; rdiazrua@gmail.com; grau_cardel@gva.es;
   franian@alumni.uv.es; zaiaji@alumni.uv.es; neusboschsi@gmail.com;
   joaquin.panadero@igenomix.com; vmviktor@gmail.com; milagros.rocha@uv.es;
   carlos.morillas@uv.es; celia.banuls@uv.es
RI VICTOR, VICTOR/I-3270-2015; Morillas, Carlos/ABF-3504-2020; Rocha,
   Milagros/I-4987-2015; Banuls, Celia/H-7359-2017; Rovira-Llopis,
   Susana/AAX-8666-2021
OI Morillas, Carlos/0000-0002-3745-4423; Rocha,
   Milagros/0000-0003-2923-6546; Bosch, Neus/0000-0002-7582-4085; Banuls,
   Celia/0000-0001-8077-7642; Diaz-Rua, Ruben/0000-0001-7046-3500;
   Rovira-Llopis, Susana/0000-0002-8476-5128
FU Carlos III Health Institute [PI18/00932, PI19/00437, PI19/00838];
   European Regional Development Fund (ERDF "A way to build Europe");
   Ministry of Education of the Valencian Regional Government
   [PROMETEO/2019/027, GRISOLIAP/2016/015, GV/2016/169]; FISABIO
   [UGP-15-220]; Menarini S.A; Sara Borrell contract [CD18/00069]; PFIS
   contracts [FI17/00144, FI19/00076]; Miguel Servet contract from Carlos
   III Health Institute [CP19/00077]
FX This study was financed by grants PI18/00932, PI19/00437,and
   PI19/00838by Carlos III Health Institute and co-funded by the European
   Regional Development Fund (ERDF "A way to build Europe");
   PROMETEO/2019/027, GRISOLIAP/2016/015, and GV/2016/169 by the Ministry
   of Education of the Valencian Regional Government; UGP-15-220 from
   FISABIO and by an unrestricted grant from Menarini S.A. R.D.-R. is a
   recipient of a Sara Borrell contract (CD18/00069), Z.A.-J. and C.G.-d.V.
   are recipients of of PFIS contracts (FI17/00144 and FI19/00076,
   respectively) and C.B. is a recipient of a Miguel Servet contract
   (CP19/00077) from Carlos III Health Institute.
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NR 39
TC 10
Z9 10
U1 1
U2 8
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2227-9059
J9 BIOMEDICINES
JI Biomedicines
PD MAR
PY 2021
VL 9
IS 3
AR 321
DI 10.3390/biomedicines9030321
PG 13
WC Biochemistry & Molecular Biology; Medicine, Research & Experimental;
   Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Research & Experimental Medicine;
   Pharmacology & Pharmacy
GA RD3XF
UT WOS:000633414500001
PM 33801145
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Bianciardi, E
   Orsaria, P
   Niolu, C
   Siracusano, A
   Gentileschi, P
AF Bianciardi, Emanuela
   Orsaria, Paolo
   Niolu, Cinzia
   Siracusano, Alberto
   Gentileschi, Paolo
TI Laparoscopic sleeve gastrectomy for morbid obesity and Klinefelter
   syndrome: clinical report on two patients, with long-term follow-up
SO EATING AND WEIGHT DISORDERS-STUDIES ON ANOREXIA BULIMIA AND OBESITY
LA English
DT Article
DE Bariatric surgery; Binge eating disorder; Klinefelter syndrome; Body
   image dissatisfaction; Metabolic syndrome; Obesity; Interdisciplinary
   approach
ID Y GASTRIC BYPASS
AB Introduction Klinefelter syndrome (KS) can appear as a wide spectrum of clinical manifestations, with no guidelines for appropriate treatment. We present the first study of bariatric surgery (BS) with a 48-month follow-up, for the management of two patients affected by obesity and KS. Cases presentation The first patient was a 32-year-old man with diagnosis of Klinefelter mosaicism (46 XY/47, XXY), Body Mass Index (BMI) of 50 kg/m(2), metabolic syndrome and Binge Eating Disorder (BED). He underwent a Laparoscopic Sleeve Gastrectomy (LSG) with weight loss (BMI = 38 kg/m(2)) and improvements to his metabolic profile at 48 months. The second patient was a 44-year-old man with KS (47, XXY), BMI of 49 kg/m(2), Obstructive Sleep Apnea Syndrome and BED. He underwent a banded LSG. After 48 months, he showed a satisfactory weight loss (BMI = 32 kg/m(2)) and amelioration of comorbidities. Conclusion In patients with KS, LSG demonstrated long-term beneficial effects for weight loss and amelioration of comorbidities. An interdisciplinary approach is mandatory, since it leads to adherence to follow-up programs and mental health well-being.
C1 [Bianciardi, Emanuela; Niolu, Cinzia; Siracusano, Alberto] Univ Tor Vergata, Dept Syst Med, Chair Psychiat, Via Montpellier 1, I-00133 Rome, Italy.
   [Orsaria, Paolo; Gentileschi, Paolo] Univ Roma Tor Vergata, Dept Surg, Obes Unit, Rome, Italy.
C3 University of Rome Tor Vergata; University of Rome Tor Vergata
RP Bianciardi, E (corresponding author), Univ Tor Vergata, Dept Syst Med, Chair Psychiat, Via Montpellier 1, I-00133 Rome, Italy.
EM emanuelabianciardi@libero.it
RI Orsaria, Paolo/AAX-7057-2021
OI NIOLU, CINZIA/0000-0001-6173-2684; bianciardi,
   emanuela/0000-0002-7486-6953; Gentileschi, Paolo/0009-0007-3068-9848
CR Bianciardi E., 2016, Journal of Food Nutritional Disorders, V5, P1, DOI DOI 10.4172/2324-9323.1000194
   Bianciardi E, 2019, RIV PSICHIATR, V54, P8, DOI 10.1708/3104.30935
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NR 13
TC 10
Z9 10
U1 1
U2 2
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1124-4909
EI 1590-1262
J9 EAT WEIGHT DISORD-ST
JI Eat. Weight Disord.-Stud. Anorex.
PD JUN
PY 2021
VL 26
IS 5
BP 1685
EP 1690
DI 10.1007/s40519-020-00951-2
EA JUL 2020
PG 6
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychiatry
GA SD6EN
UT WOS:000547353900001
PM 32654003
DA 2025-06-11
ER

PT J
AU Wildes, JE
   Marcus, MD
   Fagiolini, A
AF Wildes, Jennifer E.
   Marcus, Marsha D.
   Fagiolini, Andrea
TI Obesity in patients with bipolar disorder: A biopsychosocial-behavioral
   model
SO JOURNAL OF CLINICAL PSYCHIATRY
LA English
DT Review
ID BINGE-EATING DISORDER; PITUITARY-ADRENAL AXIS; METABOLIC SYNDROME;
   DIABETES-MELLITUS; MAJOR DEPRESSION; CHILDHOOD ABUSE; BODY-WEIGHT;
   SOCIOECONOMIC-STATUS; ATYPICAL DEPRESSION; CLINICAL-FEATURES
AB Objective: We provide a model to explicate how factors representing different levels of analysis (i.e., biology, psychology, sociodemographics, and behavior) interact to influence the onset and maintenance of obesity in bipolar disorder.
   Data Sources: We conducted MEDLINE (1966-2005) and PsycInfo (1872-2005) searches of all English-language articles using the keywords obesity, body weight, weight gain, and metabolic syndrome combined with bipolar disorder, depression, atypical depression, binge eating, and pharmacotherapy.
   Study Selection: Studies were selected if they provided data regarding (1) the prevalence of obesity in patients with bipolar disorder, (2) correlates of obesity in patients with bipolar disorder, or (3) evidence that a clinical feature(s) or correlate(s) of bipolar disorder is associated with obesity. Ninety-two studies were reviewed.
   Data Synthesis: Obesity is prevalent in patients with bipolar disorder and is associated with increased medical morbidity and poorer psychiatric outcome. Variables that may interact to influence the onset and maintenance of obesity in bipolar disorder include genetic factors, neurotransmitter abnormalities, atypical depression, eating behaviors, pharmacotherapy, age, gender, socioeconomic status, and physical inactivity.
   Conclusions: Although the exact causes of obesity in bipolar disorder undoubtedly vary across patients, the etiologic cascade, which includes biological, psychological, and sociodemographic variables, ultimately directly or indirectly affects levels of physical activity and eating behavior, leading to obesity in this population. Behavioral interventions aimed at targeting physical inactivity and overeating in bipolar disorder patients are needed, as are better screening and treatment for binge eating. Finally, there is a clear need for ongoing research to explicate the causes and consequences of obesity across levels of analysis.
C1 Univ Pittsburgh, Sch Med, Psychiat Inst & Clin, Pittsburgh, PA USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE); University
   of Pittsburgh; Western Psychiatric Institute & Clinic of UPMC
RP Wildes, JE (corresponding author), Western Psychiat Inst & Clin, 3811 OHara St, Pittsburgh, PA 15213 USA.
EM wildesje@upmc.edu
RI FAGIOLINI, ANDREA/T-2772-2017
OI FAGIOLINI, ANDREA/0000-0001-5827-0853; Wildes,
   Jennifer/0000-0003-0950-4347
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NR 126
TC 72
Z9 78
U1 0
U2 26
PU PHYSICIANS POSTGRADUATE PRESS
PI MEMPHIS
PA P O BOX 752870, MEMPHIS, TN 38175-2870 USA
SN 0160-6689
EI 1555-2101
J9 J CLIN PSYCHIAT
JI J. Clin. Psychiatry
PD JUN
PY 2006
VL 67
IS 6
BP 904
EP 915
DI 10.4088/JCP.v67n0607
PG 14
WC Psychology, Clinical; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA 059WY
UT WOS:000238764100007
PM 16848650
DA 2025-06-11
ER

PT J
AU Niccolai, E
   Boem, F
   Russo, E
   Amedei, A
AF Niccolai, Elena
   Boem, Federico
   Russo, Edda
   Amedei, Amedeo
TI The Gut-Brain Axis in the Neuropsychological Disease Model of Obesity: A
   Classical Movie Revised by the Emerging Director "Microbiome"
SO NUTRIENTS
LA English
DT Review
DE obesity; microbiota; gut-brain axis; neurological disorders; nervous
   system; inflammation
ID CHAIN FATTY-ACIDS; BODY-MASS INDEX; ENDOPLASMIC-RETICULUM STRESS;
   GRAM-NEGATIVE ENTEROBACTERIA; INFLAMMATORY-BOWEL-DISEASE;
   PROTEIN-COUPLED RECEPTOR; DIET-INDUCED OBESITY; NERVOUS-SYSTEM;
   METABOLIC SYNDROME; NEUROBEHAVIORAL CHANGES
AB The worldwide epidemic of obesity has become an important public health issue, with serious psychological and social consequences. Obesity is a multifactorial disorder in which various elements (genetic, host, and environment), play a definite role, even if none of them satisfactorily explains its etiology. A number of neurological comorbidities, such as anxiety and depression, charges the global obesity burden, and evidence suggests the hypothesis that the brain could be the seat of the initial malfunction leading to obesity. The gut microbiome plays an important role in energy homeostasis regulating energy harvesting, fat deposition, as well as feeding behavior and appetite. Dietary patterns, like the Western diet, are known to be a major cause of the obesity epidemic, probably promoting a dysbiotic drift in the gut microbiota. Moreover, the existence of a "gut-brain axis" suggests a role for microbiome on hosts' behavior according to different modalities, including interaction through the nervous system, and mutual crosstalk with the immune and the endocrine systems. In the perspective of obesity as a real neuropsychological disease and in light of the discussed considerations, this review focuses on the microbiome role as an emerging director in the development of obesity.
C1 [Niccolai, Elena; Boem, Federico; Russo, Edda; Amedei, Amedeo] Univ Florence, Dept Expt & Clin Med, Largo Brambilla 3, I-50134 Florence, Italy.
   [Amedei, Amedeo] AOUC, Dept Biomed, Largo Brambilla 3, I-50134 Florence, Italy.
C3 University of Florence; University of Florence; Azienda Ospedaliero
   Universitaria Careggi
RP Niccolai, E; Amedei, A (corresponding author), Univ Florence, Dept Expt & Clin Med, Largo Brambilla 3, I-50134 Florence, Italy.; Amedei, A (corresponding author), AOUC, Dept Biomed, Largo Brambilla 3, I-50134 Florence, Italy.
EM elena.niccolai@unifi.it; federico.boem@gmail.com; edda.russo@unifi.it;
   amedeo.amedei@unifi.it
RI Boem, Federico/ITV-7676-2023; Amedei, Amedeo/G-5378-2011; niccolai,
   elena/K-6091-2016
OI Russo, Edda/0000-0003-3141-1091; niccolai, elena/0000-0002-9205-8079;
   Boem, Federico/0000-0003-4339-6431
FU Programma Attuativo Regionale Toscana - FAS-MICpROBIMM
   [4042.16092014.066000029]; Foundation Cassa di Risparmio di Pistoia e
   Pescia [n. 2018.0005/cb]
FX This research was funded by the Programma Attuativo Regionale Toscana
   funded by FAS-MICpROBIMM grant number 4042.16092014.066000029 And The
   APC was funded by Foundation Cassa di Risparmio di Pistoia e Pescia
   [Prot. n. 2018.0005/cb].
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PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
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OA Green Submitted, Green Published, gold
DA 2025-06-11
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PT J
AU Otani, H
AF Otani, Hajime
TI Oxidative Stress as Pathogenesis of Cardiovascular Risk Associated with
   Metabolic Syndrome
SO ANTIOXIDANTS & REDOX SIGNALING
LA English
DT Review
ID ACTIVATED-RECEPTOR-GAMMA; OXIDIZED TETRAHYDROBIOPTERIN ANALOGS;
   MOLECULAR-WEIGHT ADIPONECTIN; ADIPOSE-TISSUE INFLAMMATION; MUSCLE-CELL
   PROLIFERATION; TYPE-2 DIABETES-MELLITUS; HIGH-DENSITY-LIPOPROTEIN;
   CORONARY-HEART-DISEASE; NITRIC-OXIDE SYNTHASE; CALORIC RESTRICTION
AB Metabolic syndrome (MetS) is characterized by accumulation of visceral fat associated with the clustering of metabolic and pathophysiological cardiovascular risk factors: impaired glucose tolerance, dyslipidemia, and hypertension. Although the definition of MetS is different among countries, visceral obesity is an indispensable component of MetS. A growing body of evidence suggests that increased oxidative stress to adipocytes is central to the pathogenesis of cardiovascular disease in MetS. Increased oxidative stress to adipocytes causes dysregulated expression of inflammation-related adipocytokines in MetS, which contributes to obesity-associated vasculopathy and cardiovascular risk primarily through endothelial dysfunction. The purpose of present review is to unravel the mechanistic link between oxidative stress and cardiovascular risk in MetS, focusing on insulin resistance, hypertension, and atherosclerosis. Then, therapeutic opportunities translated from the bench to bedside will be provided to develop novel strategies to cardiovascular risk factors in MetS. Antioxid. Redox Signal. 15, 1911-1926.
C1 Kansai Med Univ, Dept Internal Med 2, Moriguchi, Osaka 5708507, Japan.
C3 Kansai Medical University
RP Otani, H (corresponding author), Kansai Med Univ, Dept Internal Med 2, 10-15 Fumizono Cho, Moriguchi, Osaka 5708507, Japan.
EM otanih@takii.kmu.ac.jp
FU Ministry of Education, Science, and Culture of Japan [20590847];
   Promotion and Mutual Aid Corporation for Private Schools of Japan;
   Grants-in-Aid for Scientific Research [20590847] Funding Source: KAKEN
FX This work was supported in part by Research Grant 20590847 from the
   Ministry of Education, Science, and Culture of Japan and Promotion and
   Mutual Aid Corporation for Private Schools of Japan.
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NR 168
TC 135
Z9 144
U1 0
U2 12
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1523-0864
EI 1557-7716
J9 ANTIOXID REDOX SIGN
JI Antioxid. Redox Signal.
PD OCT
PY 2011
VL 15
IS 7
BP 1911
EP 1926
DI 10.1089/ars.2010.3739
PG 16
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 818QY
UT WOS:000294770900012
PM 21126197
DA 2025-06-11
ER

PT J
AU Kagota, S
   Tada, Y
   Nejime, N
   Nakamura, K
   Kunitomo, M
   Shinozuka, K
AF Kagota, Satomi
   Tada, Yukari
   Nejime, Namie
   Nakamura, Kazuki
   Kunitomo, Masaru
   Shinozuka, Kazumasa
TI Chronic Production of Peroxynitrite in the Vascular Wall Impairs
   Vasorelaxation Function in SHR/NDmcr-cp Rats, an Animal Model of
   Metabolic Syndrome
SO JOURNAL OF PHARMACOLOGICAL SCIENCES
LA English
DT Article
DE peroxynitrite; angiotensin II; metabolic syndrome; NADPH oxidase;
   oxidative stress
ID NITRIC-OXIDE SYNTHASE; NAD(P)H OXIDASE; NADPH OXIDASE;
   SUPEROXIDE-PRODUCTION; NITRATIVE STRESS; ENDOTHELIAL DYSFUNCTION;
   NITROSATIVE STRESS; HYPERTENSIVE-RATS; OXIDATIVE STRESS; ATHEROSCLEROSIS
AB We have previously reported that peroxynitrite is involved in dysfunction of nitric oxide (NO)-mediated vasorelaxation in SHR/NDmcr-cp rats (SHR-cp), which display typical symptoms of metabolic syndrome. This study investigated whether peroxynitrite is actually,generated in the vascular wall with angiotensin II-induced NADPH-oxidase activation, thus contributing to the dysfunction. In isolated mesenteric arteries of male 18-week-old SHR-cp, relaxations HI response to acetylcholine and sodium nitroprusside were impaired compared with that in Wistar-Kyoto rats. This impaired relaxation was not restored by treatment with apocynin, an NADPH-oxidase inhibitor. Protein expression of endothelial NO synthase increased while that Of Soluble guanylyl cyclase (sGC) decreased in the artery. We observed increased production of superoxide anions and peroxynitrite from the artery and their inhibition by apocynin, and also increased contents of nitrotyrosine, a biomarker of peroxynitrite, in mesenteric arteries and angiotensin II in aortas. Long-term (8 weeks) administration of telmisartan, an angiotensin II type 1-receptor antagonist, prevented the impaired vasorelaxation, decreased sGC expression and increased nitrotyrosine content in mesenteric arteries. These findings suggest that in the vascular wall of SHR-cp, peroxynitrite is continually produced by the reaction of NO with NADPH oxidase-derived Superoxide via angiotensin II and gradually denatures sGC protein, leading to vasorelaxation dysfunction.
C1 [Kagota, Satomi; Tada, Yukari; Nejime, Namie; Nakamura, Kazuki; Kunitomo, Masaru; Shinozuka, Kazumasa] Mukogawa Womens Univ, Dept Pharmacol, Sch Pharm & Pharmaceut Sci, Nishinomiya, Hyogo 6638179, Japan.
C3 Mukogawa Women's University
RP Kagota, S (corresponding author), Mukogawa Womens Univ, Dept Pharmacol, Sch Pharm & Pharmaceut Sci, 11-68 Koshien Kyuban Cho, Nishinomiya, Hyogo 6638179, Japan.
EM skagota@mukogawa-u.ac.jp
FU Open Research Center Project of Mukogawa Women's University; Ministry of
   Education, culture, Sports, Science, and Technology of Japan; Smoking
   Research Foundation, Japan
FX The authors are grateful to Nippon Boehringer Ingelheim Co., Ltd., Hyogo
   for their generous gift of telmisartan. We thank Ms. R. Ohta and Ms. H.
   Tsuchimoto for their technical assistance. This research was partly
   supported by the Open Research Center Project of Mukogawa Women's
   University for studying lifestyle-related diseases; a Grant-in-Aid for
   Scientific Research from the Ministry of Education, culture, Sports,
   Science, and Technology of Japan; and a grant from the Smoking Research
   Foundation, Japan.
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NR 38
TC 27
Z9 29
U1 0
U2 2
PU JAPANESE PHARMACOLOGICAL SOC
PI KYOTO
PA EDITORIAL OFF, KANTOHYA BLDG GOKOMACHI-EBISUGAWA NAKAGYO-KU, KYOTO, 604,
   JAPAN
SN 1347-8613
J9 J PHARMACOL SCI
JI J. Pharmacol. Sci.
PD APR
PY 2009
VL 109
IS 4
BP 556
EP 564
DI 10.1254/jphs.08273FP
PG 9
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 438JT
UT WOS:000265552400011
PM 19346675
OA Bronze
DA 2025-06-11
ER

PT J
AU Sena, CM
   Pereira, A
   Seiça, RM
AF Sena, Cristina M.
   Pereira, Ana
   Seica, Raquel M.
TI Cinnamaldehyde Supplementation Reverts Endothelial Dysfunction in Rat
   Models of Diet-Induced Obesity: Role of NF-E2-Related Factor-2
SO ANTIOXIDANTS
LA English
DT Article
DE endothelial dysfunction; obesity; inflammation; cinnamaldehyde; Nrf2
   activation; metabolic syndrome
ID OXIDATIVE STRESS; ANTIHYPERLIPIDEMIC ACTION; INSULIN SENSITIVITY;
   DIABETES-MELLITUS; GLUCOSE-TOLERANCE; CINNAMIC ACID; PPAR-GAMMA; NRF2;
   ANTIOXIDANT; EXPRESSION
AB Cinnamaldehyde (CN) is an activator of NF-E2-related factor 2 (Nrf2), which has the potential to reduce endothelial dysfunction, oxidative stress and inflammation in metabolic disorders. Our main purpose was to evaluate the effects of CN on vascular dysfunction in metabolic syndrome rats. Normal Wistar (W) rats were divided into eight groups: (1) Wistar (W) rats; (2) W rats fed with a high-fat diet (WHFD); (3) W rats fed with a sucrose diet (WS); (4) WHFD fed with a sucrose diet (WHFDS); (5) W treated with CN (WCn); (6) WS treated with CN (WSCn); (7) WHFD treated with CN (WHFDCn); (8) WHFDS treated with CN (WHFDSCn). CN treatment with 20 mg/kg/day was administered for 8 weeks. Evaluation of metabolic profile, inflammation, endothelial function, oxidative stress, eNOS expression levels and Nrf2 activation was performed. The metabolic dysfunction was greatly exacerbated in the WHFDS rats, accompanied by significantly higher levels of vascular oxidative stress, inflammation, and endothelial dysfunction. In addition, the WHFDS rats displayed significantly reduced activity of Nrf2 at the vascular level. CN significantly reverted endothelial dysfunction in the aortas and the mesenteric arteries. In addition, CN significantly decreased vascular oxidative damage, inflammation at vascular and perivascular level and up-regulated Nrf2 activity in the arteries of WHFDS rats. Cinnamaldehyde, an activator of Nrf2, can be used to improve metabolic profile, and to revert endothelial dysfunction in obesity and metabolic syndrome.
C1 [Sena, Cristina M.; Pereira, Ana; Seica, Raquel M.] Univ Coimbra, Inst Physiol, Fac Med, iCBR, Sub Unidade 1,Polo 3, P-3000548 Coimbra, Portugal.
C3 Universidade de Coimbra
RP Sena, CM (corresponding author), Univ Coimbra, Inst Physiol, Fac Med, iCBR, Sub Unidade 1,Polo 3, P-3000548 Coimbra, Portugal.
EM csena@ci.uc.pt
RI Pereira, Ana/KHY-3334-2024; Sena, Cristina/N-2494-2013
OI Sena, Cristina/0000-0002-0889-2977
FU FCT- Foundation for Science and Technology [UIDB/04539/2020,
   UIDP/04539/2020]; FCT [2022.04526.PTDC]
FX FCT- Foundation for Science and Technology: the Strategic Project
   UIDB/04539/2020 and UIDP/04539/2020 (CIBB); FCT project:
   2022.04526.PTDC.
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NR 68
TC 8
Z9 8
U1 3
U2 10
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD JAN
PY 2023
VL 12
IS 1
AR 82
DI 10.3390/antiox12010082
PG 14
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA 8B4CO
UT WOS:000916872600001
PM 36670944
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Korchia, T
   Tastevin, M
   De Verville, PLS
   Joober, R
   Andrieu-Haller, C
   Faugere, M
   Godin, O
   Etchecopar-Etchart, D
   Berna, F
   Aouizerate, B
   Capdevielle, D
   Chereau, I
   Clauss-Kobayashi, J
   Coulon, N
   Dorey, JM
   Dubertret, C
   Dubreucq, J
   Mallet, J
   Misdrahi, D
   Passerieux, C
   Rey, R
   Schürhoff, F
   Szoke, A
   Urbach, M
   Leboyer, M
   Llorca, PM
   Lançon, C
   Richieri, R
   Boyer, L
   Fond, G
AF Korchia, Theo
   Tastevin, Maud
   De Verville, Pierre-Louis Sunhary
   Joober, Ridha
   Andrieu-Haller, Christelle
   Faugere, Melanie
   Godin, Ophelia
   Etchecopar-Etchart, Damien
   Berna, Fabrice
   Aouizerate, Bruno
   Capdevielle, Delphine
   Chereau, Isabelle
   Clauss-Kobayashi, Julie
   Coulon, Nathalie
   Dorey, Jean-Michel
   Dubertret, Caroline
   Dubreucq, Julien
   Mallet, Jasmina
   Misdrahi, David
   Passerieux, Christine
   Rey, Romain
   Schurhoff, Frank
   Szoke, Andrei
   Urbach, Mathieu
   Leboyer, Marion
   Llorca, Pierre-Michel
   Lancon, Christophe
   Richieri, Raphaelle
   Boyer, Laurent
   Fond, Guillaume
TI Precision-medicine findings from the FACE-SZ cohort to develop
   motivation-enhancing programs in real-world schizophrenia
SO WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
LA English
DT Article
DE Psychiatry; mental health; schizophrenia; mood disorders; depressive
   disorders; quality of life
ID SUBSTANCE USE DISORDERS; OF-LIFE QUESTIONNAIRE; NEGATIVE SYMPTOMS;
   PHYSICAL-ACTIVITY; SLEEP QUALITY; MENTAL-HEALTH; RATING-SCALE;
   DOUBLE-BLIND; DEPRESSION; INDIVIDUALS
AB Background In people with schizophrenia, major areas of everyday life are impaired, including independent living, productive activities, social relationships and overall quality of life. Enhanced understanding of factors that hinder real-life functioning is vital for treatments to translate into more positive outcomes. Aim The goal of the present study was to identify factors associated with motivation deficits in real-life schizophrenia, and to assess its contribution to impaired functioning and quality of life. Methods Based on previous literature and clinical experience, several factors were selected and grouped into factors potentially explaining motivation deficits. Some of these variables were never investigated before in relationship with motivation deficits. Results In 561 patients with schizophrenia of the national FACE-SZ cohort living in the community, 235 (41.9%) reported severe motivation deficits. These deficits were found to be significantly associated with impaired socially useful activities, psychological and physical quality of life (in almost all domains), alcohol use disorder (aOR = 2.141, p = 0.021), severe nicotine dependence (aOR = 2.906, p < 0.001) independently of age and sex. No significant association was found for body mass index, metabolic syndrome or physical activity level. In the second model, we identified the following modifiable factors associated with motivation deficits: history of suicide attempt (aOR = 2.297, p = 0.001), positive symptoms (aOR = 1.052, p = 0.006), current major depressive episode (aOR = 2.627, p < 0.001), sleep disorders (aOR = 1.474, p = 0.024) and lower medication adherence (aOR = 0.836, p = 0.001) independently of gender, current alcohol use disorder, second-generation antipsychotics and akathisia. No significant association was found for negative symptoms, childhood trauma and inflammation. These results were maintained after removing patients with schizoaffective disorders or those with major depressive disorder. Interpretation Motivation deficits are frequent and remain persistent unmet need in real-world schizophrenia that should be addressed in future guidelines. Based on our results, literature and clinical experience, we recommend to address in priority major depression, sleep, suicide, positive symptoms (when present and as early as possible) and medication adherence to improve motivation deficits of schizophrenia.
C1 [Korchia, Theo; Tastevin, Maud; Andrieu-Haller, Christelle; Faugere, Melanie; Godin, Ophelia; Etchecopar-Etchart, Damien; Berna, Fabrice; Aouizerate, Bruno; Capdevielle, Delphine; Chereau, Isabelle; Clauss-Kobayashi, Julie; Coulon, Nathalie; Dorey, Jean-Michel; Dubertret, Caroline; Dubreucq, Julien; Mallet, Jasmina; Misdrahi, David; Passerieux, Christine; Rey, Romain; Schurhoff, Frank; Szoke, Andrei; Urbach, Mathieu; Leboyer, Marion; Llorca, Pierre-Michel; Lancon, Christophe; Richieri, Raphaelle; Boyer, Laurent; Fond, Guillaume] Fdn FondaMental, Creteil, France.
   [Korchia, Theo; Tastevin, Maud; De Verville, Pierre-Louis Sunhary; Andrieu-Haller, Christelle; Faugere, Melanie; Etchecopar-Etchart, Damien; Lancon, Christophe; Richieri, Raphaelle; Boyer, Laurent; Fond, Guillaume] Aix Marseille Univ, Fac Med, CEReSS Ctr Etud & Rech Serv Sante & Qualite Vie, Sect Timone,EA 327,AP HM, 27 Blvd Jean Moulin, F-13005 Marseille, France.
   [Joober, Ridha] McGill Univ, Douglas Mental Hlth Univ Inst, Dept Psychiat, Prevent & Early Intervent Program Psychosis PEPP, Montreal, PQ, Canada.
   [Berna, Fabrice; Clauss-Kobayashi, Julie] Univ Strasbourg, Hop Univ Strasbourg, Federat Med Translat Strasbourg, INSERM U1114, Strasbourg, France.
   [Aouizerate, Bruno; Misdrahi, David] Univ Bordeaux, Pole Psychiat Gen & Univ, Ctr Hosp Charles Perrens, CNRS UMR 5287 INCIA, F-33076 Bordeaux, France.
   [Aouizerate, Bruno] Univ Bordeaux, NutriNeuro, INRA, Bordeaux, France.
   [Capdevielle, Delphine] Univ Montpellier, Serv Univ Psychiat Adulte, INSERM, CNRS,Hop Colombiere,CHRU Montpellier,IGF, Montpellier, France.
   [Chereau, Isabelle; Llorca, Pierre-Michel] Univ Clermont Auvergne, Clermont Auvergne INP, CNRS, CHU,CMP B, Clermont Ferrand, France.
   [Coulon, Nathalie; Dubreucq, Julien] CH Alpes Isere, Ctr Referent Rehabil Psychosociale, Grenoble, France.
   [Dorey, Jean-Michel; Rey, Romain] Univ Claude Bernard Lyon 1, Ctr Rech Neurosci Lyon, INSERM U1028, CNRS UMR5292, Bron, France.
   [Dubertret, Caroline; Mallet, Jasmina] Univ Paris, Louis Mourier Hosp, AP HP, Dept Psychiat, Paris, France.
   [Misdrahi, David] Univ Bordeaux, CNRS UMR 5287, INCIA, Bordeaux, France.
   [Passerieux, Christine; Urbach, Mathieu] Serv Univ Psychiat Adultes & dAddictol, Ctr Hosp Versailles, Le Chesnay, France.
   [Passerieux, Christine; Urbach, Mathieu] Univ Paris Saclay, INSERM UMR1018, DisAP DevPsy CESP, Villejuif, France.
   [Schurhoff, Frank; Szoke, Andrei; Leboyer, Marion] Univ Paris Est Creteil UPEC, Hop Univ H Mondor, AP HP, Fdn FondaMental,DMU IMPACT,INSERM,IMRB,Translat N, Creteil, France.
C3 Aix-Marseille Universite; Assistance Publique-Hopitaux de Marseille;
   McGill University; Universites de Strasbourg Etablissements Associes;
   Universite de Strasbourg; CHU Strasbourg; Institut National de la Sante
   et de la Recherche Medicale (Inserm); Universite de Bordeaux; INRAE;
   Universite de Bordeaux; Centre National de la Recherche Scientifique
   (CNRS); Universite de Montpellier; Institut National de la Sante et de
   la Recherche Medicale (Inserm); CHU de Montpellier; Universite Clermont
   Auvergne (UCA); CHU Clermont Ferrand; Centre National de la Recherche
   Scientifique (CNRS); Polytechnic Institute of Clermont Auvergne; Centre
   National de la Recherche Scientifique (CNRS); CNRS - National Institute
   for Biology (INSB); Institut National de la Sante et de la Recherche
   Medicale (Inserm); Universite Claude Bernard Lyon 1; Universite Jean
   Monnet; Universite Paris Cite; Assistance Publique Hopitaux Paris
   (APHP); Hopital Universitaire Louis-Mourier - APHP; Universite de
   Bordeaux; Centre National de la Recherche Scientifique (CNRS); CNRS -
   National Institute for Biology (INSB); Universite Paris Saclay; Centre
   Hospitalier de Versailles; Institut National de la Sante et de la
   Recherche Medicale (Inserm); Universite Paris Saclay; Institut National
   de la Sante et de la Recherche Medicale (Inserm); Universite
   Paris-Est-Creteil-Val-de-Marne (UPEC); Assistance Publique Hopitaux
   Paris (APHP); Hopital Universitaire Henri-Mondor - APHP
RP Fond, G (corresponding author), Aix Marseille Univ, Fac Med, CEReSS Ctr Etud & Rech Serv Sante & Qualite Vie, Sect Timone,EA 327,AP HM, 27 Blvd Jean Moulin, F-13005 Marseille, France.
EM guillaume.fond@ap-hm.fr
RI Mallet, Jasmina/GNP-7160-2022; Berna, Fabrice/J-2701-2019; Fond,
   Guillaume/D-7646-2011; COULON, Nathalie/HLW-3075-2023; Clauss-Kobayashi,
   Julie/JWA-4713-2024; JeanMichel, Dorey/KHZ-0906-2024; Capdevielle,
   Delphine/HTO-4229-2023; Etchecopar-Etchart, Damien/ADR-6419-2022;
   richieri, raphaelle/E-4707-2015; Faugere, Melanie/JCP-3459-2023; Boyer,
   Laurent/E-5728-2016
OI Sunhary de Verville, Pierre-Louis/0000-0002-1378-5682; Boyer,
   Laurent/0000-0003-1229-6622; dubreucq, julien/0000-0003-4079-4194;
   Korchia, Theo/0000-0002-6392-9322; Faugere, Melanie/0000-0001-5567-8650;
   Aouizerate, Bruno/0000-0002-7092-7747; COULON,
   Nathalie/0000-0001-7765-1117
FU AP-HM (Assistance Publique des Hopitaux de Marseille); Fondation
   FondaMental (RTRS Sante Mentale); Investissements d'Avenir Program
   [ANR-11-IDEX-0004-02, ANR10-COHO-10-01]; INSERM (Institut National de la
   Sante et de la Recherche Medicale)
FX This work was funded by AP-HM (Assistance Publique des H<^>opitaux de
   Marseille), Fondation FondaMental (RTRS Sant~e Mentale), by the
   Investissements d'Avenir Program managed by the ANR under reference
   [ANR-11-IDEX-0004-02 and ANR10-COHO-10-01, and by INSERM (Institut
   National de la Sant~e et de la Recherche M~edicale).
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NR 85
TC 2
Z9 2
U1 3
U2 11
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1562-2975
EI 1814-1412
J9 WORLD J BIOL PSYCHIA
JI World J. Biol. Psychiatry
PD OCT 21
PY 2022
VL 23
IS 9
BP 703
EP 714
DI 10.1080/15622975.2022.2031286
EA JAN 2022
PG 12
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychiatry
GA 7P0PU
UT WOS:000749365400001
PM 35057713
OA Green Published
DA 2025-06-11
ER

PT J
AU Venojärvi, M
   Korkmaz, A
   Wasenius, N
   Manderoos, S
   Heinonen, OJ
   Lindholm, H
   Aunola, S
   Eriksson, JG
   Atalay, M
AF Venojarvi, Mika
   Korkmaz, Ayhan
   Wasenius, Niko
   Manderoos, Sirpa
   Heinonen, Olli J.
   Lindholm, Harri
   Aunola, Sirkka
   Eriksson, Johan G.
   Atalay, Mustafa
TI 12 Weeks' aerobic and resistance training without dietary intervention
   did not influence oxidative stress but aerobic training decreased
   atherogenic index in middle-aged men with impaired glucose regulation
SO FOOD AND CHEMICAL TOXICOLOGY
LA English
DT Article
DE Nordic walking; Resistance training; Oxidative stress; Metabolic
   syndrome; Impaired glucose regulation; Atherogenic index
ID TYPE-2 DIABETIC-PATIENTS; HIGH-DENSITY-LIPOPROTEIN;
   LINKED-IMMUNOSORBENT-ASSAY; CORONARY-ARTERY-DISEASE; METABOLIC SYNDROME;
   ENDOTHELIAL FUNCTION; CARDIOVASCULAR RISK; INSULIN-RESISTANCE; NORDIC
   WALKING; PLASMA OSTEOPONTIN
AB Our aim was to determine whether 12 weeks' aerobic Nordic walking (NW) or resistance exercise training (RT) without diet-induced weight loss could decrease oxidative stress and atherogenic index of plasma (AIP), prevalence of metabolic syndrome (MetS) and MetS score in middle-aged men with impaired glucose regulation (IGR) (n = 144. 54.5 +/- 6.5 years). In addition, we compared effects of intervention between overweight and obese subgroups.
   Prevalence of MetS and AIP index decreased only in NW group and MetS score in both NW and RT groups but not in control group. The changes in AIP index correlated inversely with changes in plasma antioxidant capacity. The change in AIP index remained a significant independent predictor of the changes in MetS score after the model was adjusted for age, BMI and volume of exercise (MET h/week) in NW group. There were no changes in the other measured markers of oxidative stress and related cytokines (e.g. osteopontin and osteoprotegerin) in any of the groups.
   Nordic walking decreased prevalence of MetS and MetS score. Improved lipid profile remained a predictor of decreased MetS score only in NW group and it seems that Nordic walking has more beneficial effects on cardiovascular disease risks than RT training. (C) 2013 Elsevier Ltd. All rights reserved.
C1 [Venojarvi, Mika; Korkmaz, Ayhan; Atalay, Mustafa] Univ Eastern Finland, Inst Biomed, Kuopio 70211, Finland.
   [Wasenius, Niko; Manderoos, Sirpa; Eriksson, Johan G.] Univ Helsinki, Dept Gen Practice & Primary Hlth Care, Helsinki, Finland.
   [Manderoos, Sirpa; Aunola, Sirkka] Natl Inst Hlth & Welf, Dept Chron Dis Prevent, Helsinki, Finland.
   [Manderoos, Sirpa; Aunola, Sirkka] Natl Inst Hlth & Welf, Dept Chron Dis Prevent, Turku, Finland.
   [Manderoos, Sirpa; Aunola, Sirkka] Natl Inst Hlth & Welf, Dept Hlth Funct Capac & Welf, Turku, Finland.
   [Heinonen, Olli J.] Univ Turku, Dept Physiol, Paavo Nurmi Ctr, Turku, Finland.
   [Heinonen, Olli J.] Univ Turku, Dept Hlth & Phys Act, Turku, Finland.
   [Lindholm, Harri] Finnish Inst Occupat Hlth, Helsinki, Finland.
   [Eriksson, Johan G.] Univ Helsinki, Gen Hosp, Unit Gen Practice, Helsinki, Finland.
   [Eriksson, Johan G.] Folkhalsan Res Ctr, Helsinki, Finland.
   [Eriksson, Johan G.] Vaasa Cent Hosp, Vaasa, Finland.
C3 University of Eastern Finland; University of Helsinki; Finland National
   Institute for Health & Welfare; Finland National Institute for Health &
   Welfare; Finland National Institute for Health & Welfare; University of
   Turku; University of Turku; Finnish Institute of Occupational Health;
   University of Helsinki; Folkhalsan Research Center; Vaasa Central
   Hospital
RP Atalay, M (corresponding author), Univ Eastern Finland, Inst Biomed, POB 1627, Kuopio 70211, Finland.
EM mustafa.atalay@uef.fi
RI Wasenius, Niko/AAE-8927-2020; Gibbs, J. Raphael/A-3984-2010; Heinonen,
   Olli/AAG-7298-2019
OI Heinonen, Olli J./0000-0002-1722-1729; Wasenius,
   Niko/0000-0002-9007-6660; Aunola, Sirkka/0000-0003-2681-1541; Venojarvi,
   Mika/0000-0003-1327-9760; Eriksson, Johan/0000-0002-2516-2060
FU Research Council for Physical Education and Sports; Finnish Ministry of
   Education; Turku University of Applied Sciences RD program; COST action
   [CM1001]
FX The authors wish to express their gratitude to Mr. Jouni Kettunen and
   Juha Pyyhtia for excellent technical assistance especially in the HMW
   adiponectin, OPG and OPN measurements, Senior lecturers Riitta Nikkonen
   and Marja Kelander for sampling and clinical chemistry students'
   guidance. The study was supported by grants from the Research Council
   for Physical Education and Sports, of the Finnish Ministry of Education,
   Turku University of Applied Sciences R&D program and the COST action
   CM1001.
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NR 73
TC 26
Z9 28
U1 0
U2 19
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0278-6915
EI 1873-6351
J9 FOOD CHEM TOXICOL
JI Food Chem. Toxicol.
PD NOV
PY 2013
VL 61
BP 127
EP 135
DI 10.1016/j.fct.2013.04.015
PG 9
WC Food Science & Technology; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Toxicology
GA 280AK
UT WOS:000329000800020
PM 23623841
DA 2025-06-11
ER

PT J
AU Steptoe, A
   Marmot, M
AF Steptoe, A
   Marmot, M
TI Burden of psychosocial adversity and vulnerability in middle age:
   Associations with biobehavioral risk factors and quality of life
SO PSYCHOSOMATIC MEDICINE
LA English
DT Article
DE psychosocial factors; stress; socioeconomic position; quality of life;
   coronary heart disease
ID CORONARY-HEART-DISEASE; SOCIOECONOMIC-STATUS; CARDIOVASCULAR-DISEASE;
   SOCIAL SUPPORT; METABOLIC SYNDROME; MAJOR DEPRESSION; CIVIL-SERVANTS;
   JOB CONTROL; STRESS; HEALTH
AB Objectives: Numerous psychosocial factors are associated with disease risk. This study investigated the possibility that a combination of chronic stress from exposure to multiple sources and absence of protective psychosocial resources would be related to heightened emotional distress, health risk behavior, biological risk factors, and impaired quality of life, independently of socioeconomic position (SEP). Materials and Methods: Data were analyzed from 227 men and women aged 47 to 59 years from the Whitehall 11 epidemiological cohort. A psychosocial adversity and vulnerability index (PAVIX) was constructed from high scores on measures of job demands, neighborhood stress, and financial strain, low emotional support, limited social networks, low active coping, and low sense of control. Results: The measures making up the PAVIX were relatively independent of one another. Scores on the PAVIX were greater in lower SEP participants, and in single, separated, or divorced than married participants. The PAVIX was positively associated with psychological distress, depression, hopelessness, sleep problems, hostility, low self-esteem and loneliness, independently of age, sex, SEP, and marital status. There were no associations with health behaviors, but relationships were observed with glycohemoglobin, plasma fibrinogen, plasma viscosity, and body mass (women), that were again independent of covariates. Individuals with high PAVIX scores also reported impaired health-related quality of life. Discussion: The accumulated burden of life stress coupled with limited protective psychosocial resources is associated with adverse psychological, biological, and quality of life outcomes. This integrated approach to the investigation of psychosocial factors may prove valuable in understanding etiological processes.
C1 UCL, Dept Epidemiol & Publ Hlth, London WC1E 6BT, England.
C3 University of London; University College London
RP UCL, Dept Epidemiol & Publ Hlth, 1-19 Torrington Pl, London WC1E 6BT, England.
EM a.steptoe@ucl.ac.uk
RI Steptoe, Andrew/Y-2440-2019; Marmot, Michael/Y-3920-2019
OI Steptoe, Andrew/0000-0001-7808-4943; Marmot, Michael/0000-0002-2431-6419
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NR 54
TC 65
Z9 82
U1 0
U2 22
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0033-3174
EI 1534-7796
J9 PSYCHOSOM MED
JI Psychosom. Med.
PD NOV-DEC
PY 2003
VL 65
IS 6
BP 1029
EP 1037
DI 10.1097/01.PSY.0000097347.57237.2D
PG 9
WC Psychiatry; Psychology; Psychology, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry; Psychology
GA 748QK
UT WOS:000186872400015
PM 14645782
DA 2025-06-11
ER

PT J
AU Mihaylova, R
   Gevrenova, R
   Petrova, A
   Savov, Y
   Zheleva-Dimitrova, D
   Balabanova, V
   Momekov, G
   Simeonova, R
AF Mihaylova, Rositsa
   Gevrenova, Reneta
   Petrova, Alexandra
   Savov, Yonko
   Zheleva-Dimitrova, Dimitrina
   Balabanova, Vessela
   Momekov, Georgi
   Simeonova, Rumyana
TI Mitigating Effects of Tanacetum balsamita L. on Metabolic
   Dysfunction-Associated Fatty Liver Disease (MAFLD)
SO PLANTS-BASEL
LA English
DT Article
DE metabolic syndrome; obesity; metabolic-associated fatty liver disease;
   oxidative stress; antioxidants; polyphenols; Tanacetum balsamita
ID OXIDATIVE STRESS; ANTIOXIDANT ACTIVITY; RATS; ACARBOSE; EXTRACT; OBESE;
   NAFLD
AB The metabolic syndrome and its associated co-morbidities have been recognized as predisposing risk factors for the development of metabolic-associated fatty liver disease (MAFLD). The present study reports on the beneficial effect of the Tanacetum balsamita methanol-aqueous extract (ETB) at 150 and 300 mg/kg bw on biochemical parameters related to oxidative stress, metabolic syndrome, and liver function in rat animal models with induced MAFLD. ETB was found to be non-toxic with LD50 > 3000 mg/kg and did not affect cell viability of hepatic HEP-G2 cells in a concentration up to 800 mu g/mL. The pathology was established by a high-calorie diet and streptozotocin. Acarbose and atorvastatin were used as positive controls. At the higher dose, ETB reduced significantly (p < 0.05) the blood glucose levels by about 20%, decreased lipase activity by 52%, total cholesterol and triglycerides by 50% and 57%, respectively, and restored the amylase activity and leukocytes compared to the MAFLD group. ETB ameliorated oxidative stress biomarkers reduced glutathione and malondialdehyde in a dose-dependent manner. At 300 mg/kg, the beneficial effect of the extract on antioxidant enzymes was evidenced by the elevated catalase, glutathione peroxidase, and superoxide dismutase activity by 70%, 29%, and 44%, accordingly, compared to the MAFLD rats. ETB prevents the histopathological changes related to MAFLD. ETB, rich in 3,5-dicafeoylquinic, chlorogenic, and rosmarinic acids together with the isorhamnetin- and luteolin-glucoside provides a prominent amelioration of MAFLD.
C1 [Mihaylova, Rositsa; Petrova, Alexandra; Momekov, Georgi; Simeonova, Rumyana] Med Univ Sofia, Fac Pharm, Dept Pharmacol Pharmacotherapy & Toxicol, Sofia 1000, Bulgaria.
   [Gevrenova, Reneta; Zheleva-Dimitrova, Dimitrina; Balabanova, Vessela] Med Univ Sofia, Fac Pharm, Dept Pharmacognosy, Sofia 1000, Bulgaria.
   [Savov, Yonko] Inst Emergency Med NI Pirogov, Bul Totleben 21, Sofia 1000, Bulgaria.
C3 Medical University Sofia; Medical University Sofia
RP Gevrenova, R (corresponding author), Med Univ Sofia, Fac Pharm, Dept Pharmacognosy, Sofia 1000, Bulgaria.
EM rmihaylova@pharmfac.mu-sofia.bg; rgevrenova@pharmfac.mu-sofia.bg;
   aleksandrapetrova91@yahoo.com; yonko_savov@hotmail.com;
   dzheleva@pharmfac.mu-sofia.bg; vbalabanova@pharmfac.mu-sofia.bg;
   gmomekov@pharmfac.mu-sofia.bg; rsimeonova@pharmfac.mu-sofia.bg
RI Momekov, Georgi/H-4178-2019; Gevrenova, Reneta/AEA-8791-2022; Mihaylova,
   Rositsa/AAR-4778-2021; Balabanova, Vessela/AAV-6720-2021; Simeonova,
   Rumyana/G-8002-2019; Zheleva-Dimitrova, Dimitrina/GQI-1010-2022
OI Simeonova, Rumyana/0000-0003-4860-9053; Mihaylova,
   Rositsa/0000-0001-5763-0730; Balabanova, Vessela/0000-0002-9938-6542;
   Gevrenova, Reneta/0000-0002-1254-2419; Zheleva-Dimitrova,
   Dimitrina/0000-0002-1952-9903
FU European Union-NextGenerationEU; NationalRecovery and Resilience Plan of
   the Republic of Bulgaria [BG-RRP-2.004-0004-C01]; Strategicresearch and
   innovation program for development of Medical university-Sofia
FX This study is financed by the European Union-Next GenerationEU through
   the NationalRecovery and Resilience Plan of the Republic of Bulgaria,
   project BG-RRP-2.004-0004-C01 "Strategicresearch and innovation program
   for development of Medical university-Sofia
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NR 60
TC 4
Z9 4
U1 2
U2 5
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 2223-7747
J9 PLANTS-BASEL
JI Plants-Basel
PD AUG
PY 2024
VL 13
IS 15
AR 2086
DI 10.3390/plants13152086
PG 18
WC Plant Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences
GA C2P6J
UT WOS:001287830100001
PM 39124206
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Shi, YS
   Li, CB
   Li, XY
   Wu, J
   Li, Y
   Fu, X
   Zhang, Y
   Hu, WZ
AF Shi, Yu-Sheng
   Li, Chun-Bin
   Li, Xiao-Ying
   Wu, Jiao
   Li, Yang
   Fu, Xin
   Zhang, Yan
   Hu, Wen-Zhong
TI Fisetin Attenuates Metabolic Dysfunction in Mice Challenged with a
   High-Fructose Diet
SO JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
LA English
DT Article
DE metabolic syndrome; fisetin; oxidative stress; inflammation; high
   fructose
ID NF-KAPPA-B; INDUCED DIABETIC-RATS; OXIDATIVE STRESS; FLAVONOID FISETIN;
   INFLAMMATORY MARKERS; REACTIVE OXYGEN; IN-VIVO; MECHANISMS; INHIBITION;
   ANTIOXIDANT
AB Excess fructose consumption can lead to metabolic syndrome, including insulin resistance, dyslipidemia, and hepatic injury, which are associated with oxidative stress and inflammation. The present study was to investigate whether fisetin improved multiple disturbances induced by fructose consumption. First, fisetin was found to be nontoxic to mice after an 8 week treatment. Second, the mice fed with a high-fructose (HFru)-diet for 8 weeks exhibited insulin resistance, dyslipidemia, hepatic injury, oxidative stress, and inflammation. Fisetin supplementation effectively improved the undesirable results mentioned above when compared to the HFru group. Meanwhile, fisetin significantly suppressed the nuclear factor kappa-lightchain-enhancer of activated B cells (NF-kappa B) pathway and activated the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway in mice fed with HFru. Our findings demonstrated that fisetin exerted the beneficial effects in HFra-feeding mice, which might be associated with suppression of NF-kappa B and activation of the Nrf2 pathway.
C1 [Shi, Yu-Sheng; Li, Chun-Bin; Li, Xiao-Ying; Wu, Jiao; Li, Yang] Dalian Nationalities Univ, Coll Life Sci, Key Lab Biotechnol & Bioresources Utilizat, Minist Educ, Dalian 116600, Liaoning, Peoples R China.
   [Fu, Xin] Heilongjiang Univ Chinese Med, Dept Pharmacognosy, Harbin 150040, Heilongjiang, Peoples R China.
   [Zhang, Yan; Hu, Wen-Zhong] Heilongjiang Univ Chinese Med, Jiamusi Coll, Jiamusi 154007, Heilongjiang, Peoples R China.
C3 Ministry of Education - China; Dalian Minzu University; Heilongjiang
   University of Chinese Medicine; Heilongjiang University of Chinese
   Medicine
RP Zhang, Y; Hu, WZ (corresponding author), Heilongjiang Univ Chinese Med, Jiamusi Coll, Jiamusi 154007, Heilongjiang, Peoples R China.
EM zhangyan1600@126.com; hwz@dlnu.edu.cn
RI Chang, Jack/HGC-1227-2022; Fu, Xin/HLH-5953-2023
FU Natural Science Foundation of Liaoning Province of China [20170540201];
   Fundamental Research Funds for the Central Universities; Dr. Start-up
   Fund of Dalian Nationalities University; Heilongjiang University of
   Chinese Medicine [201736]; State Key Laboratory of Bioactive Substance
   and Function of Natural Medicines [GTZK201702]; Academy of Finland (AKA)
   [201736] Funding Source: Academy of Finland (AKA)
FX The authors thank the support from the Natural Science Foundation of
   Liaoning Province of China (20170540201), the Fundamental Research Funds
   for the Central Universities, the Dr. Start-up Fund of Dalian
   Nationalities University, the Science Research Fund Project of
   Heilongjiang University of Chinese Medicine (201736), and the Open
   Research Fund of State Key Laboratory of Bioactive Substance and
   Function of Natural Medicines (GTZK201702).
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NR 37
TC 25
Z9 25
U1 0
U2 20
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0021-8561
EI 1520-5118
J9 J AGR FOOD CHEM
JI J. Agric. Food Chem.
PD AUG 8
PY 2018
VL 66
IS 31
BP 8291
EP 8298
DI 10.1021/acs.jafc.8b02140
PG 8
WC Agriculture, Multidisciplinary; Chemistry, Applied; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture; Chemistry; Food Science & Technology
GA GQ2IG
UT WOS:000441476400010
PM 30040414
DA 2025-06-11
ER

PT J
AU Simao, ANC
   Dichi, JB
   Barbosa, DS
   Cecchini, R
   Dichi, I
AF Colado Simao, Andrea Name
   Dichi, Jane Bandeira
   Barbosa, Decio Sabbatini
   Cecchini, Rubens
   Dichi, Isaias
TI Influence of uric acid and γ-glutamyltransferase on total antioxidant
   capacity and oxidative stress in patients with metabolic syndrome
SO NUTRITION
LA English
DT Article
DE metabolic syndrome; oxidative stress; gamma-glutamyltransferase; uric
   acid; antioxidant defense
ID INSULIN-RESISTANCE; CARDIOVASCULAR-DISEASE; LIPID-PEROXIDATION;
   TRANSPEPTIDASE; RISK; LIVER; HEART; GLUTAMYLTRANSFERASE; MORTALITY;
   CANCER
AB Objective: Metabolic syndrome (MS) is a cluster of risk factors for cardiovascular disease related mainly to insulin resistance, but also to oxidative stress. Uric acid and gamma-glutamyltransferase (GGT) levels are also associated with MS and oxidative stress. This study was undertaken to assess the role of GGT and uric acid in adult patients with MS and its relation to oxidative stress and antioxidant defense.
   Methods: A total of 88 adults (67 with MS and 21 controls) were selected among ambulatory patients and workers of the University Hospital of Londrina, Parana, Brazil. Oxidative stress was assessed by determination of thiobarbituric acid-reactive substances and tert-butyl hydroperoxide-initiated chemiluminescence and antioxidant defenses by total radical-trapping antioxidant parameter.
   Results: The MS group presented higher significant results (P < 0.0001) than the control group in all parameters of MS and uric acid and GGT levels and significant lower values (P < 0.0001) in high-density lipoprotein cholesterol levels. Thiobarbituric acid-reactive substances and total radical-trapping antioxidant parameter did not show statistically significant differences between groups. However, lipid hydroperoxides, evaluated by tert-butyl hydroperoxide-initiated chemiluminescence, showed higher significant results in the MS group (P = 0.045) than in the control group. Total antioxidant capacity did not decrease and thiobarbituric acid-reactive substances did not increase, probably due to increased uric acid (r = 0.239, P = 0.04) in the MS group.
   Conclusion: The present study confirmed that GGT is a strong predictor of MS and that lipid peroxide measured by tert-butyl hydroperoxide-initiated chemiluminescence and GGT activity are reliable markers of oxidative stress in this syndrome. (C) 2008 Elsevier Inc. All rights reserved.
C1 [Dichi, Jane Bandeira; Dichi, Isaias] Univ Londrina, Dept Internal Med, Londrina, Parana, Brazil.
   [Colado Simao, Andrea Name; Barbosa, Decio Sabbatini] Univ Londrina, Dept Pathol Clin Anal & Toxicol, Londrina, Parana, Brazil.
   [Cecchini, Rubens] Univ Londrina, Lab Pathophysiol Free Radicals, Londrina, Parana, Brazil.
RP Dichi, I (corresponding author), Univ Londrina, Dept Internal Med, Londrina, Parana, Brazil.
EM dichi@sercomtel.com.br
RI Barbosa, Décio/AAE-6351-2019; Simão, Andrea/AAM-4892-2021; Cecchini,
   Rubens/D-9811-2013
OI Cecchini, Rubens/0000-0001-9941-2344
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NR 41
TC 45
Z9 48
U1 0
U2 7
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0899-9007
EI 1873-1244
J9 NUTRITION
JI Nutrition
PD JUL-AUG
PY 2008
VL 24
IS 7-8
BP 675
EP 681
DI 10.1016/j.nut.2008.03.021
PG 7
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 320CE
UT WOS:000257210500009
PM 18499396
DA 2025-06-11
ER

PT J
AU Motta, AB
AF Motta, Alicia Beatriz
TI Polycystic Ovary Syndrome and Oxidative Stress. Natural Treatments
SO CURRENT MEDICINAL CHEMISTRY
LA English
DT Review
DE Polycystic ovary syndrome (PCOS); oxidative stress (OS); insulin
   resistance (IR); anti- oxidant defenses; metabolic syndrome (MS);
   beta-carotene
ID TOTAL ANTIOXIDANT CAPACITY; ANTI-MULLERIAN HORMONE; GLYCATION
   END-PRODUCTS; IN-VITRO; METABOLIC SYNDROME; CONTROLLED-TRIAL;
   DOUBLE-BLIND; MELATONIN; SUPPLEMENTATION; MAGNESIUM
AB Polycystic ovary syndrome (PCOS) is one of the most frequent endocrinopathology affecting women in their reproductive ages. However, PCOS is also related to metabolic abnormalities such as metabolic syndrome (MS), insulin resistance (IR), and type 2 diabetes, among others. Consequently, an inflammatory and pro-oxidative status is also present in these patients, aggravating the syndrome's symptoms. This work aims to discuss some late treatments that focus on oxidative stress (OS) as a central feature related to primary PCOS abnormalities. Therefore, this review focuses on the evidence of anti-oxidant diets, natural compounds, mineralocorticoids, and combined therapies for PCOS management. Oxidative stress (OS) is important in PCOS pathogenesis. In this regard, increased levels of oxidative oxygen species and decreased levels of anti-oxidant agents' impact PCOS's reproductive and metabolic features. In the last years, non-pharmacological therapies have been considered a first line of treatment. For these reasons, several natural compounds such as Kelult honey (KH), Foeniculum vulgare, Calendula officinalis Linn, Eugenia caryophyllus and Myristicafragrans, vitamin C, vitamin E, selenium, zinc, beta-carotene, magnesium, curcumin, mineralocorticoids and melatonin alone or in combination are powerful anti-oxidant agents being used for PCOS management. Data presented here suggest that natural therapies are essential in managing both reproductive and metabolic features in PCOS patients. Due to the results obtained, these incipient therapies deserve further investigation.
C1 [Motta, Alicia Beatriz] Univ Buenos Aires UBA, Ctr Estudios Farmacol & Bot CEFYBO, Consejo Nacl Invest Cient & Tecnol CONICET, Fac Med,Lab Fisiopatol Ovar, Paraguay 2155, RA-1121 Buenos Aires, Argentina.
RP Motta, AB (corresponding author), Univ Buenos Aires UBA, Ctr Estudios Farmacol & Bot CEFYBO, Consejo Nacl Invest Cient & Tecnol CONICET, Fac Med,Lab Fisiopatol Ovar, Paraguay 2155, RA-1121 Buenos Aires, Argentina.
EM aliciabmotta@yahoo.com.ar
OI Motta, Alicia/0000-0002-8478-728X
FU National Council Research (CONICET) [CONICET PIP 1872/20]
FX This review was supported by National Council Research (CONICET),
   CONICET PIP 1872/20.
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NR 86
TC 0
Z9 0
U1 4
U2 16
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 0929-8673
EI 1875-533X
J9 CURR MED CHEM
JI Curr. Med. Chem.
PY 2025
VL 32
IS 8
BP 1457
EP 1468
DI 10.2174/0109298673270372231130071320
EA FEB 2024
PG 12
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Pharmacology &
   Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
GA 0DK6F
UT WOS:001176915800001
PM 38549535
DA 2025-06-11
ER

PT J
AU Kessler, HS
   Sisson, SB
   Short, KR
AF Kessler, Holly S.
   Sisson, Susan B.
   Short, Kevin R.
TI The Potential for High-Intensity Interval Training to Reduce
   Cardiometabolic Disease Risk
SO SPORTS MEDICINE
LA English
DT Review
ID CONTINUOUS MODERATE EXERCISE; ALL-CAUSE MORTALITY; SPRINT INTERVAL;
   METABOLIC ADAPTATIONS; ARTERIAL STIFFNESS; PHYSICAL-FITNESS;
   BLOOD-PRESSURE; HEALTHY; OVERWEIGHT; ENDURANCE
AB In the US, 34% of adults currently meet the criteria for the metabolic syndrome defined by elevated waist circumference, plasma triglycerides (TG), fasting glucose and/or blood pressure, and decreased high-density lipoprotein cholesterol (HDL-C). While these cardiometabolic risk factors can be treated with medication, lifestyle modification is strongly recommended as a first-line approach. The purpose of this review is to focus on the effect of physical activity interventions and, specifically, on the potential benefits of incorporating higher intensity exercise. Several recent studies have suggested that compared with continuous moderate exercise (CME), high-intensity interval training (HIT) may result in a superior or equal improvement in fitness and cardiovascular health. HIT is comprised of brief periods of high-intensity exercise interposed with recovery periods at a lower intensity. The premise of using HIT in both healthy and clinical populations is that the vigorous activity segments promote greater adaptations via increased cellular stress, yet their short length, and the ensuing recovery intervals, allow even untrained individuals to work harder than would otherwise be possible at steady-state intensity. In this review, we examine the impact of HIT on cardiometabolic risk factors, anthropometric measures of obesity and cardiovascular fitness in both healthy and clinical populations with cardiovascular and metabolic disease. The effects of HIT versus CME on health outcomes were compared in 14 of the 24 studies featuring HIT. Exercise programmes ranged from 2 weeks to 6 months. All 17 studies that measured aerobic fitness and all seven studies that measured insulin sensitivity showed significant improvement in response to HIT, although these changes did not always exceed responses to CME comparison groups. A minimum duration of 12 weeks was necessary to demonstrate improvement in fasting glucose in four of seven studies (57%). A minimum duration of 8 weeks of HIT was necessary to demonstrate improvement in HDL-C in three of ten studies (30%). No studies reported that HIT resulted in improvement of total cholesterol, low-density lipoprotein cholesterol (LDL-C), or TG. At least 12 weeks of HIT was required for reduction in blood pressure to emerge in five studies of participants not already being treated for hypertension. A minimum duration of 12 weeks was necessary to see consistent improvement in the six studies that examined anthropometric measures of obesity in overweight/obese individuals. In the 13 studies with a matched-exercise-volume CME group, improvement in aerobic fitness in response to HIT was equal to (5 studies), or greater than (8 studies) in response to CME. Additionally, HIT has been shown to be safe and effective in patients with a range of cardiac and metabolic dysfunction. In conclusion, HIT appears to promote superior improvements in aerobic fitness and similar improvements in some cardiometabolic risk factors in comparison to CME, when performed by healthy subjects or clinical patients for at least 8-12 weeks. Future studies need to address compliance and efficacy of HIT in the real world with a variety of populations.
C1 [Kessler, Holly S.] Univ Oklahoma, Hlth Sci Ctr, Sect Pediat Emergency Med, Oklahoma City, OK 73104 USA.
   [Kessler, Holly S.; Sisson, Susan B.] Univ Oklahoma, Hlth Sci Ctr, Dept Nutr Sci, Oklahoma City, OK 73104 USA.
   [Short, Kevin R.] Univ Oklahoma, Hlth Sci Ctr, Sect Pediat Diabet & Endocrinol, Oklahoma City, OK 73104 USA.
C3 University of Oklahoma System; University of Oklahoma Health Sciences
   Center; University of Oklahoma System; University of Oklahoma Health
   Sciences Center; University of Oklahoma System; University of Oklahoma
   Health Sciences Center
RP Kessler, HS (corresponding author), Univ Oklahoma, Hlth Sci Ctr, Sect Pediat Emergency Med, 940 NE 13th St,2G-2300, Oklahoma City, OK 73104 USA.
EM Holly-Kessler@ouhsc.edu
RI Short, Kevin/AAC-2553-2020
OI Short, Kevin/0000-0001-6704-9587
FU University of Oklahoma Health Sciences Center; National Center for
   Research Resources (NCRR), National Institutes of Health (NIH)
   [P20RR024215]
FX Susan B. Sisson is supported by a University of Oklahoma Health Sciences
   Center Vice President of Research Seed Grant for study entitled Sitting
   Versus Light Activity and Cardiovascular Disease Risk: Influence of a
   High Fat Meal. Kevin R. Short is supported by grant number P20RR024215
   from the National Center for Research Resources (NCRR), a component of
   the National Institutes of Health (NIH). Holly S. Kessler has received
   no funding and the authors have no conflicts of interest to declare that
   are directly relevant to the content of this review.
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NR 46
TC 307
Z9 371
U1 6
U2 189
PU ADIS INT LTD
PI NORTHCOTE
PA 5 THE WAREHOUSE WAY, NORTHCOTE 0627, AUCKLAND, NEW ZEALAND
SN 0112-1642
EI 1179-2035
J9 SPORTS MED
JI Sports Med.
PY 2012
VL 42
IS 6
BP 489
EP 509
DI 10.2165/11630910-000000000-00000
PG 21
WC Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Sport Sciences
GA 952MD
UT WOS:000304795700004
PM 22587821
DA 2025-06-11
ER

PT J
AU Prasun, P
AF Prasun, Pankaj
TI Role of mitochondria in pathogenesis of type 2 diabetes mellitus
SO JOURNAL OF DIABETES AND METABOLIC DISORDERS
LA English
DT Review
DE Mitochondria; Diabetes; Diabetes mellitus; Metabolic syndrome;
   Mitochondrial dysfunction; Insulin resistance
ID ENDOPLASMIC-RETICULUM STRESS; BETA-CELL DYSFUNCTION; OXIDATIVE STRESS;
   DYNAMICS; SECRETION; FISSION; GENES; FATE
AB Type 2 diabetes mellitus (T2DM) is global health problem. An estimated 425 million people in the world had diabetes in 2017. It is a major cause of morbidity and mortality worldwide. Although, pathogenesis of T2DM and its complications have been focus of medical research for long, much remains to be learned. A better understanding of molecular pathogenesis is essential for more effective preventive and therapeutic interventions. Role of mitochondria in pathogenesis of metabolic problems such as obesity, metabolic syndrome, and T2DM is the focus of many recent research studies. Mitochondrial dysfunction contributes to the oxidative stress and systemic inflammation leading to insulin resistance (IR). Mitochondria are also essential for pancreatic beta cell insulin secretion. Hence, mitochondria are important players in the pathogenesis of T2DM. In this article, pathogenesis of T2DM is examined from a mitochondrial perspective.
C1 [Prasun, Pankaj] Icahn Sch Med Mt Sinai, Dept Genet & Genom Sci, One Gustave L Levy Pl,Box 1497, New York, NY 10029 USA.
C3 Icahn School of Medicine at Mount Sinai
RP Prasun, P (corresponding author), Icahn Sch Med Mt Sinai, Dept Genet & Genom Sci, One Gustave L Levy Pl,Box 1497, New York, NY 10029 USA.
EM Pankaj.Prasun@mssm.edu
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NR 52
TC 38
Z9 39
U1 2
U2 63
PU SPRINGER INT PUBL AG
PI CHAM
PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND
EI 2251-6581
J9 J DIABETES METAB DIS
JI J. Diabetes Metab. Disord.
PD DEC
PY 2020
VL 19
IS 2
BP 2017
EP 2022
DI 10.1007/s40200-020-00679-x
EA NOV 2020
PG 6
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA QC8UX
UT WOS:000588100600001
PM 33520874
OA Green Published
DA 2025-06-11
ER

PT J
AU Ajiboye, TO
   Raji, HO
   Adeleye, AO
   Adigun, NS
   Giwa, OB
   Ojewuyi, OB
   Oladiji, AT
AF Ajiboye, Taofeek O.
   Raji, Hikmat O.
   Adeleye, Abdulwasiu O.
   Adigun, Nurudeen S.
   Giwa, Oluwayemisi B.
   Ojewuyi, Oluwayemisi B.
   Oladiji, Adenike T.
TI Hibiscus sabdariffa calyx palliates insulin resistance,
   hyperglycemia, dyslipidemia and oxidative rout in fructose-induced
   metabolic syndrome rats
SO JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
LA English
DT Article
DE Hibiscus sabdariffa; metabolic syndrome; dyslipidemia; oxidative stress;
   insulin resistance
ID APPROVED RECOMMENDATION 1985; LIPID-PEROXIDATION; 2-OXOGLUTARATE
   AMINOTRANSFERASE; DETOXIFICATION POTENTIALS; CATALYTIC CONCENTRATION;
   PROTEIN OXIDATION; AQUEOUS EXTRACT; IFCC METHODS; ANTIOXIDANT; STRESS
AB BACKGROUND: The effect of Hibiscus sabdariffa calyx extract was evaluated in high-fructose-induced metabolic syndrome rats. Insulin resistance, hyperglycemia, dyslipidemia and oxidative rout were induced in rats using high-fructose diet. High-fructose diet-fed rats were administered 100 and 200 mg kg(-1) body weight of H. sabdariffa extract for 3 weeks, starting from week 7 of high-fructose diet treatment.
   RESULTS: High-fructose diet significantly (P < 0.05) increased the serum levels of blood glucose, insulin, total cholesterol (TC), triacylglycerol (TAG), low-density lipoprotein cholesterol (LDLc) and very-low-density lipoprotein cholesterol (VLDLc), with a concomitant reduction in high-density lipoprotein cholesterol (HDLc). These alterations were significantly ameliorated by the extract. High-fructose diet-mediated decreases in the activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione reductase (GSH-red) and glucose 6-phosphate dehydrogenase (Glc 6-PD) were significantly (P < 0.05) attenuated. Altered levels of reduced glutathione (GSH) and glutathione disulfide (GSSG) were significantly (P < 0.05) restored to normal. High-fructose diet-mediated increases in the concentrations of malondialdehyde, conjugated dienes, lipid hydroperoxides, protein carbonyl and percentage fragmented DNA were significantly (P < 0.05) lowered by the Hibiscus extract.
   CONCLUSION: Overall, aqueous extract of H. sabdariffa palliates insulin resistance, hyperglycemia, dyslipidemia and oxidative rout in high-fructose-induced metabolic syndrome rats. (C) 2015 Society of Chemical Industry
C1 [Ajiboye, Taofeek O.; Ojewuyi, Oluwayemisi B.] Al Hikmah Univ, Antioxidants Free Radicals Funct Foods & Toxicol, Dept Biol Sci, Llorin, Nigeria.
   [Raji, Hikmat O.] Fountain Univ, Antioxidants Free Radicals & Toxicol Res Lab, Dept Chem Sci, Osogbo, Nigeria.
   [Adeleye, Abdulwasiu O.; Adigun, Nurudeen S.; Giwa, Oluwayemisi B.; Oladiji, Adenike T.] Univ Llorin, Dept Biochem, Llorin, Nigeria.
RP Ajiboye, TO (corresponding author), Al Hikmah Univ, Antioxidants Free Radicals Funct Foods & Toxicol, Dept Biol Sci, Llorin, Nigeria.
EM ajiboyeyong@yahoo.com
RI Ajiboye, Taofeek/H-5383-2011
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NR 44
TC 30
Z9 30
U1 1
U2 14
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-5142
EI 1097-0010
J9 J SCI FOOD AGR
JI J. Sci. Food Agric.
PD MAR 30
PY 2016
VL 96
IS 5
BP 1522
EP 1531
DI 10.1002/jsfa.7254
PG 10
WC Agriculture, Multidisciplinary; Chemistry, Applied; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture; Chemistry; Food Science & Technology
GA DG8EX
UT WOS:000372316700014
PM 25965053
DA 2025-06-11
ER

PT J
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   Burlina, Alberto
   Biasucci, Giacomo
TI Nutrition, Microbiota and Role of Gut-Brain Axis in Subjects with
   Phenylketonuria (PKU): A Review
SO NUTRIENTS
LA English
DT Review
DE diet; nutrients; microbial; inherited errors of metabolism; immune
   response; neurological function; anxiety; depression
ID CHAIN FATTY-ACIDS; INTESTINAL MICROBIOTA; INBORN-ERRORS; BOVINE
   GLYCOMACROPEPTIDE; METABOLIC SYNDROME; NITRIC-OXIDE; L-CARNITINE; DIET;
   OBESITY; STRESS
AB The composition and functioning of the gut microbiota, the complex population of microorganisms residing in the intestine, is strongly affected by endogenous and exogenous factors, among which diet is key. Important perturbations of the microbiota have been observed to contribute to disease risk, as in the case of neurological disorders, inflammatory bowel disease, obesity, diabetes, cardiovascular disease, among others. Although mechanisms are not fully clarified, nutrients interacting with the microbiota are thought to affect host metabolism, immune response or disrupt the protective functions of the intestinal barrier. Similarly, key intermediaries, whose presence may be strongly influenced by dietary habits, sustain the communication along the gut-brain-axis, influencing brain functions in the same way as the brain influences gut activity. Due to the role of diet in the modulation of the microbiota, its composition is of high interest in inherited errors of metabolism (IEMs) and may reveal an appealing therapeutic target. In IEMs, for example in phenylketonuria (PKU), since part of the therapeutic intervention is based on chronic or life-long tailored dietetic regimens, important variations of the microbial diversity or relative abundance have been observed. A holistic approach, including a healthy composition of the microbiota, is recommended to modulate host metabolism and affected neurological functions.
C1 [Verduci, Elvira] Univ Milan, Vittore Buzzi Childrens Hosp, Dept Paediat, Via Lodovico Castelvetro 32, I-20154 Milan, Italy.
   [Verduci, Elvira; Borghi, Elisa; Ottaviano, Emerenziana] Univ Milan, Dept Hlth Sci, Via Rudini 8, I-20142 Milan, Italy.
   [Carbone, Maria Teresa] AORN Santobono, UOS Metab & Rare Dis, Via Mario Fiore 6, I-80122 Naples, Italy.
   [Burlina, Alberto] Univ Hosp Padua, Div Inborn Metab Dis, Dept Diagnost Serv, Via Orus 2B, I-35129 Padua, Italy.
   [Biasucci, Giacomo] Guglielmo da Saliceto Hosp, Dept Paediat & Neonatol, Via Taverna Giuseppe 49, I-29121 Piacenza, Italy.
C3 University of Milan; University of Milan; University of Padua; Azienda
   Ospedaliera - Universita di Padova; Guglielmo da Saliceto Hospital
RP Verduci, E (corresponding author), Univ Milan, Vittore Buzzi Childrens Hosp, Dept Paediat, Via Lodovico Castelvetro 32, I-20154 Milan, Italy.; Verduci, E (corresponding author), Univ Milan, Dept Hlth Sci, Via Rudini 8, I-20142 Milan, Italy.
EM elvira.verduci@unimi.it; mt.carbone@santobonopausilipon.it;
   elisa.borghi@unimi.it; emerenziana.ottaviano@unimi.it;
   alberto.burlina@unipd.it; g.biasucci@ausl.pc.it
RI Verduci, Elvira/D-7338-2014; Borghi, Elisa/I-8811-2012; burlina,
   alberto/AHE-6095-2022; biasucci, giacomo/X-9186-2018
OI Verduci, Elvira/0000-0003-2111-3111; biasucci,
   giacomo/0000-0002-7441-9248; burlina, alberto/0000-0001-7724-137X;
   Borghi, Elisa/0000-0002-1893-0455
FU Piam Farmaceutici S.p.A (Genoa, Italy)
FX The authors thank Piam Farmaceutici S.p.A (Genoa, Italy) for financially
   supporting the project. The sponsor had no role in the conception or
   content implementation of the review.
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NR 233
TC 25
Z9 26
U1 0
U2 13
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD NOV
PY 2020
VL 12
IS 11
AR 3319
DI 10.3390/nu12113319
PG 31
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA OX6WT
UT WOS:000593703100001
PM 33138040
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Hilton, NZ
   Ham, E
   Hill, S
   Emmanuel, T
   Thege, BK
AF Hilton, N. Zoe
   Ham, Elke
   Hill, Stephanie
   Emmanuel, Talia
   Thege, Barna Konkoly
TI Predictors of Weight Gain and Metabolic Indexes among Men Admitted to
   Forensic Psychiatric Hospital
SO INTERNATIONAL JOURNAL OF FORENSIC MENTAL HEALTH
LA English
DT Article
DE Forensic; inpatient; length of stay; metabolic syndrome; weight
ID MAJOR DEPRESSIVE DISORDER; BIPOLAR DISORDER; PHYSICAL HEALTH; ILLNESS;
   OBESITY; RISK; ANTIPSYCHOTICS; SCHIZOPHRENIA; PREVALENCE; PEOPLE
AB People with mental health disorders face elevated risk of metabolic syndrome (MetS), which increases the risk of serious health problems and premature mortality. Obesity is prevalent among those hospitalized in forensic psychiatric units, and substantial weight gains during hospitalization have been reported. We examined International Diabetes Federation (IDF) criteria and proxy MetS indexes (body mass index [BMI], blood pressure, and waist circumference) in the medical records of 527 men admitted to a forensic hospital, and tested predictors of weight gain during their first year or less in hospital. IDF indexes were documented for 22% of men whereas proxy indexes were documented for 46%. Both suggested similar MetS prevalence: 16% IDF, 17% proxy. Weight gain averaged 1.72 kg per month; BMI, being a smoker, and length of stay were independent predictors. Interventions focusing on these risk factors are advisable in order to support both mental and physical health among individuals admitted to forensic psychiatric services. The proxy MetS indexes offer a rapid screening measure and a promising tool for research studies and clinical practice in the absence of blood test results.
C1 [Hilton, N. Zoe; Ham, Elke; Hill, Stephanie; Emmanuel, Talia; Thege, Barna Konkoly] Waypoint Ctr Mental Hlth Care, Waypoint Res Inst, Penetanguishene, ON, Canada.
   [Hilton, N. Zoe; Thege, Barna Konkoly] Univ Toronto, Dept Psychiat, Toronto, ON, Canada.
C3 University of Toronto
RP Hilton, NZ (corresponding author), Waypoint Ctr Mental Hlth Care, Waypoint Res Inst, Penetanguishene, ON, Canada.
EM zhilton@waypointcentre.ca
RI Hilton, N./J-2660-2019; Hilton, N. Zoe/E-3896-2015; Konkoly Thege,
   Barna/U-2253-2019
OI Hilton, N. Zoe/0000-0002-7961-0615; Konkoly Thege,
   Barna/0000-0002-0861-8978; Hill, Stephanie/0000-0001-9107-5531; Ham,
   Elke/0000-0001-7368-3090; Emmanuel, Talia/0000-0001-5595-685X
FU Public Safety Canada
FX We thank Alecia Dretzkat, Carol Lang, Chelsea Turan, Courtney Duthie,
   Craig Rafla, Desiree Robitaille, Jenna Rutherford, Oleg Belanovsky,
   Shealyn May, and Sonja Dey for research assistance, Laurie Wells for
   helpful discussions on metabolic syndrome in psychiatric settings, and
   Waypoint's clinical program and clinical information staff for
   assistance. This research was supported in part by a grant from Public
   Safety Canada. The views expressed are those of the authors and not
   necessarily those of Public Safety Canada.
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NR 41
TC 6
Z9 6
U1 0
U2 0
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1499-9013
EI 1932-9903
J9 INT J FORENSIC MENT
JI Int. J. Forensic Ment. Health
PD APR 3
PY 2022
VL 21
IS 2
BP 164
EP 174
DI 10.1080/14999013.2021.1952356
EA JUL 2021
PG 11
WC Criminology & Penology; Psychiatry
WE Social Science Citation Index (SSCI)
SC Criminology & Penology; Psychiatry
GA 0T6KN
UT WOS:000674827700001
DA 2025-06-11
ER

PT J
AU Chanda, F
   Lin, KX
   Chaurembo, AI
   Huang, JY
   Zhang, HJ
   Deng, WH
   Xu, YJ
   Li, Y
   Fu, LD
   Cui, HD
   Shu, C
   Chen, Y
   Xing, N
   Lin, HB
AF Chanda, Francis
   Lin, Kai-xuan
   Chaurembo, Abdallah Iddy
   Huang, Jian-yuan
   Zhang, Hui-juan
   Deng, Wen-hui
   Xu, Yun-jing
   Li, Yuan
   Fu, Li-dan
   Cui, Hao-dong
   Shu, Chi
   Chen, Yang
   Xing, Na
   Lin, Han-bin
TI PM2.5-mediated cardiovascular disease in aging:
   Cardiometabolic risks, molecular mechanisms and potential interventions
SO SCIENCE OF THE TOTAL ENVIRONMENT
LA English
DT Review
DE PM2.5; Cardiovascular disease; Cardiometabolic risk; Older adults;
   Inflammation; Oxidative stress; Oxidative stress
ID FINE PARTICULATE MATTER; LONG-TERM EXPOSURE; FATTY LIVER-DISEASE;
   AIR-POLLUTION; AMBIENT PM2.5; OXIDATIVE STRESS; SUBCLINICAL
   ATHEROSCLEROSIS; PARTICLE EXPOSURE; BLOOD-PRESSURE; CAROTID
   ATHEROSCLEROSIS
AB Air pollution, particularly fine particulate matter (PM2.5) with <2.5 mu m in diameter, is a major public health concern. Studies have consistently linked PM2.5 exposure to a heightened risk of cardiovascular diseases (CVDs) such as ischemic heart disease (IHD), heart failure (HF), and cardiac arrhythmias. Notably, individuals with pre-existing age-related cardiometabolic conditions appear more susceptible. However, the specific impact of PM2.5 on CVDs susceptibility in older adults remains unclear. Therefore, this review addresses this gap by discussing the factors that make the elderly more vulnerable to PM2.5-induced CVDs. Accordingly, we focused on physiological aging, increased susceptibility, cardiometabolic risk factors, CVDs, and biological mechanisms. This review concludes by examining potential interventions to reduce exposure and the adverse health effects of PM2.5 in the elderly population. The latter includes dietary modifications, medications, and exploration of the potential benefits of supplements. By comprehensively analyzing these factors, this review aims to provide a deeper understanding of the detrimental effects of PM2.5 on cardiovascular health in older adults. This knowledge can inform future research and guide strategies to protect vulnerable populations from the adverse effects of air pollution.
C1 [Chanda, Francis; Chaurembo, Abdallah Iddy; Huang, Jian-yuan; Zhang, Hui-juan; Deng, Wen-hui; Xu, Yun-jing; Li, Yuan; Fu, Li-dan; Cui, Hao-dong; Shu, Chi; Xing, Na; Lin, Han-bin] Chinese Acad Sci, SIMM, Zhongshan Inst Drug Discovery, Zhongshan, Guangdong, Peoples R China.
   [Chanda, Francis; Chaurembo, Abdallah Iddy; Xu, Yun-jing; Lin, Han-bin] Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Chem Biol, Shanghai, Peoples R China.
   [Chanda, Francis; Chaurembo, Abdallah Iddy; Xu, Yun-jing; Chen, Yang; Lin, Han-bin] Univ Chinese Acad Sci, Beijing, Peoples R China.
   [Lin, Kai-xuan] Guangzhou Univ Tradit Chinese Med, Zhongshan Hosp Tradit Chinese Med, Dept Cardiol, Zhongshan, Guangdong, Peoples R China.
   [Lin, Kai-xuan; Li, Yuan] Guangzhou Univ Chinese Med, Guangzhou, Guangdong, Peoples R China.
   [Huang, Jian-yuan; Deng, Wen-hui] Southern Med Univ, Sch Pharmaceut Sci, Guangzhou, Guangdong, Peoples R China.
   [Zhang, Hui-juan; Fu, Li-dan] Zunyi Med Univ, Sch Pharm, Zunyi, Guizhou, Peoples R China.
   [Cui, Hao-dong] Guizhou Med Univ, Sch Pharmaceut Sci, Guiyang, Guizhou, Peoples R China.
   [Shu, Chi] Shenyang Agr Univ, Food Sci Coll, Shenyang, Liaoning, Peoples R China.
   [Chen, Yang] Chinese Acad Sci, Chongqing Inst Green & Intelligent Technol, Res Ctr Atmospher Environm, Chongqing, Peoples R China.
C3 Chinese Academy of Sciences; Chinese Academy of Sciences; Shanghai
   Institute of Materia Medica, CAS; Chinese Academy of Sciences;
   University of Chinese Academy of Sciences, CAS; Guangzhou University of
   Chinese Medicine; Guangzhou University of Chinese Medicine; Southern
   Medical University - China; Zunyi Medical University; Guizhou Medical
   University; Shenyang Agricultural University; Chinese Academy of
   Sciences; Chongqing Institute of Green & Intelligent Technology, CAS
RP Xing, N; Lin, HB (corresponding author), Chinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, Zhongshan, Peoples R China.
EM xingna@zidd.ac.cn; linhanbin@simm.ac.cn
RI Xu, Yunjing/L-2166-2013; Shu, Chi/ABB-5582-2021; Jianyuan,
   Huang/AFL-8145-2022
FU ANSO Scholarship for Young Talent [2022ANSOM122]; National Natural
   Science Foundation of China [82100391]; Guangdong Provincial Pearl River
   Talents Program [211283781015]; State key Laboratory of Drug Research of
   Shanghai Institute of Materia Medica Chinese Academy of Sciences
   [SKLDR-2024-KF-08]; High-level New RD Institute [2019B090904008];
   High-level Innovative Research Institute [2021B0909050003]; Zhongshan
   Science and Technology Bureau [2023B2031]
FX This study was sponsored by the ANSO Scholarship for Young Talent to
   Francis Chanda (2022ANSOM122 to Francis Chanda) and research grants from
   the National Natural Science Foundation of China (82100391 to H-B. L.) ,
   Guangdong Provincial Pearl River Talents Program (211283781015 to H-B.
   L.) , State key Laboratory of Drug Research of Shanghai Institute of
   Materia Medica Chinese Academy of Sciences (Grant Nos. SKLDR-2024-KF-08)
   , High-level New R&D Institute (2019B090904008 to H-B. L.) , and
   High-level Innovative Research Institute (2021B0909050003 to H-B. L) ,
   Zhongshan Science and Technology Bureau (Grant Nos. 2023B2031 to N. X.)
   .
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NR 240
TC 9
Z9 9
U1 18
U2 25
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0048-9697
EI 1879-1026
J9 SCI TOTAL ENVIRON
JI Sci. Total Environ.
PD DEC 1
PY 2024
VL 954
AR 176255
DI 10.1016/j.scitotenv.2024.176255
EA SEP 2024
PG 22
WC Environmental Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology
GA H1M0X
UT WOS:001321139300001
PM 39276993
OA hybrid
DA 2025-06-11
ER

PT J
AU Carreira, MC
   Izquierdo, AG
   Amil, M
   Casanueva, FF
   Crujeiras, AB
AF Carreira, Marcos C.
   Izquierdo, Andrea G.
   Amil, Maria
   Casanueva, Felipe F.
   Crujeiras, Ana B.
TI Oxidative Stress Induced by Excess of Adiposity Is Related to a
   Downregulation of Hepatic SIRT6 Expression in Obese Individuals
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Article
ID GENE-EXPRESSION; FATTY LIVER; HEPATOCELLULAR-CARCINOMA; OVERWEIGHT;
   SIRTUINS; DISEASE; MICE
AB Sirt6 is a member of the sirtuin family involved in physiological and pathological processes including aging, cancer, obesity, diabetes, and energy metabolism. This study is aimed at evaluating the relationship between liver SIRT6 gene expression and the oxidative stress network depending on adiposity levels in Zucker rats, an animal model of metabolic syndrome. We observed that liver-specific SIRT6 expression is reduced in an in vivo model of spontaneous obesity and metabolic syndrome. We also observed that SIRT6 expression in the liver is positively associated with SIRTI and GST-M2 expressions, two proteins involved in antioxidant protection pathways and inversely related to body weight and plasmatic oxidative status. Interestingly, the SIRT6 expression is upregulated after energy restriction-induced weight loss concomitantly with an improvement in oxidative stress markers. These results suggest that SIRT6 may be a potential therapeutic target for the treatment of obesity and associated metabolic disorders, such as liver disease.
C1 [Carreira, Marcos C.; Amil, Maria; Casanueva, Felipe F.] CHUS, Inst Invest Sanitaria Santiago IDIS, Lab Mol & Cellular Endocrinol, Santiago De Compostela, Spain.
   [Carreira, Marcos C.; Izquierdo, Andrea G.; Amil, Maria; Casanueva, Felipe F.; Crujeiras, Ana B.] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr CIBERobn, Madrid, Spain.
   [Izquierdo, Andrea G.; Crujeiras, Ana B.] CHUS, SERGAS, Inst Invest Sanitaria Santiago IDIS, Lab Epigen Endocrinol & Nutr,Epigen Unit, Santiago De Compostela, Spain.
   [Casanueva, Felipe F.] USC, Santiago De Compostela, Spain.
C3 Complexo Hospitalario Universitario de Santiago de Compostela; CIBER -
   Centro de Investigacion Biomedica en Red; CIBEROBN; Instituto de Salud
   Carlos III; Complexo Hospitalario Universitario de Santiago de
   Compostela; Universidade de Santiago de Compostela
RP Casanueva, FF (corresponding author), CHUS, Inst Invest Sanitaria Santiago IDIS, Lab Mol & Cellular Endocrinol, Santiago De Compostela, Spain.; Casanueva, FF; Crujeiras, AB (corresponding author), Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr CIBERobn, Madrid, Spain.; Crujeiras, AB (corresponding author), CHUS, SERGAS, Inst Invest Sanitaria Santiago IDIS, Lab Epigen Endocrinol & Nutr,Epigen Unit, Santiago De Compostela, Spain.; Casanueva, FF (corresponding author), USC, Santiago De Compostela, Spain.
EM endocrine@usc.es; anabelencrujeiras@hotmail.com
RI Chas-Amil, M.L./N-9316-2018; Izquierdo, Andrea G/HLX-1356-2023;
   Crujeiras, Ana B/ABA-8866-2021
OI CASANUEVA, FELIPE F./0000-0002-9052-8161; Izquierdo, Andrea
   G/0000-0002-0846-8834; Crujeiras, Ana B/0000-0003-4392-0301
FU Centro de Investigacion Biomedica en Red de Fisiopatologia de la
   Obesidad y Nutricion (CIBERobn); Instituto de Salud Carlos III
   [PI17/01287, CP17/00088]; European Regional Development Fund (FEDER);
   CIBERobn
FX Authors thank Maribel Rendo from the Department of Molecular and
   Cellular Endocrinology of Instituto de Investigacion Sanitaria de
   Santiago (IDIS) for her support of research data management. This study
   was supported by Centro de Investigacion Biomedica en Red de
   Fisiopatologia de la Obesidad y Nutricion (CIBERobn) and grants from the
   Instituto de Salud Carlos III (PI17/01287) cofinanced by the European
   Regional Development Fund (FEDER). Andrea G. Izquierdo is funded by
   CIBERobn and Ana B. Crujeiras is funded by a research contract "Miguel
   Servet" (CP17/00088) from the Instituto de Salud Carlos III, cofinanced
   by the European Regional Development Fund (FEDER).
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NR 25
TC 24
Z9 25
U1 1
U2 2
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PY 2018
VL 2018
AR 6256052
DI 10.1155/2018/6256052
PG 7
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA HG2VP
UT WOS:000454825200001
PM 30671172
OA Green Published, hybrid, Green Submitted
DA 2025-06-11
ER

PT J
AU Papelbaum, M
   Moreira, RO
   Gaya, CWD
   Preissler, C
   Coutinho, WF
AF Papelbaum, Marcelo
   Moreira, Rodrigo Oliveira
   do Nascimento Gaya, Caroline Wust
   Preissler, Carolina
   Coutinho, Walmir Ferreira
TI Impact of body mass index on the psychopathological profile of obese
   women
SO REVISTA BRASILEIRA DE PSIQUIATRIA
LA English
DT Article
DE Obesity; Linear models; Somatoform disorders; Body Mass Index
ID BECK DEPRESSION INVENTORY; PSYCHOLOGICAL DISTRESS;
   PSYCHIATRIC-DISORDERS; METABOLIC-SYNDROME; BARIATRIC SURGERY;
   PREVALENCE; WEIGHT; ASSOCIATION; SYMPTOMS; RISK
AB Objective: Obesity is a complex condition associated with a host of medical disorders. One common assumption is that obesity is also related to psychological and emotional complications. However, some studies have shown that obesity itself does not appear to be systematically associated with psychopathological outcomes. The objective of the present study was to evaluate the impact that the various degrees of obesity have on the psychopathological profile of obese patients. Method: The study sample consisted of 217 women classified as obese (body mass index >= 30 kg/m(2)) who sought medical treatment for weight loss and were consecutively invited to participate in the study. Anthropometric data were registered for all participants. Psychiatric evaluations were performed using the Beck Depression Inventory and Symptom Checklist-90. Multiple regression analysis was used in order to determine whether any of the studied variables (age, level of education, Beck Depression Inventory score and body mass index) were independently correlated with the score on the different subscales of the Symptom Checklist-90. Results: Only body mass index was found to correlate significantly with the score on the somatization subscale of the Symptom Checklist-90 (r = 0.148, p = 0.035). This correlation remained significant after multiple regression analysis (p = 0.03). No correlation was found between body mass index and the score on any of the other subscales. Conclusion: The degree of obesity did not correlate with any of the psychological profiles commonly described in the medical literature, including depression and anxiety. The correlation between obesity and somatization, although weak, might simply be related to an overlapping of symptoms.
C1 [Papelbaum, Marcelo; Moreira, Rodrigo Oliveira; do Nascimento Gaya, Caroline Wust; Preissler, Carolina; Coutinho, Walmir Ferreira] UFRJ, Inst Estadual Diabet & Endocrinol, IPUB, GOTA, BR-20211340 Rio De Janeiro, Brazil.
   [Papelbaum, Marcelo; Moreira, Rodrigo Oliveira; do Nascimento Gaya, Caroline Wust; Preissler, Carolina; Coutinho, Walmir Ferreira] UFRJ, Inst Psiquiatria, IPUB, GOTA, BR-20211340 Rio De Janeiro, Brazil.
   [Moreira, Rodrigo Oliveira; do Nascimento Gaya, Caroline Wust; Preissler, Carolina; Coutinho, Walmir Ferreira] PUC RJ, Rio De Janeiro, Brazil.
   [Moreira, Rodrigo Oliveira] Fundacao Educ Dom Andre Arcoverde, Ctr Ensino Super Valenca, Valenca, RJ, Brazil.
C3 Universidade Federal do Rio de Janeiro; Universidade Federal do Rio de
   Janeiro; Pontificia Universidade Catolica do Rio de Janeiro
RP Moreira, RO (corresponding author), UFRJ, Inst Estadual Diabet & Endocrinol, IPUB, GOTA, Rua Moncorvo Filho 90 Ctr, BR-20211340 Rio De Janeiro, Brazil.
EM rom_br@yahoo.com
RI Moreira, Rodrigo/N-7131-2015; Papelbaum, Marcelo/C-1548-2013
CR Andreucci M, 1999, MINER ELECTROL METAB, V25, P32, DOI 10.1159/000057416
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NR 31
TC 16
Z9 18
U1 0
U2 11
PU ASSOC BRASILEIRA PSIQUIATRIA
PI SAO PAULO
PA SUBSCRIPTION DEPARTMENT, RUA PEDRO DE TOLEDO, 967 - CASA 01, SAO PAULO,
   SP 04039-032  A, BRAZIL
SN 1516-4446
EI 1809-452X
J9 REV BRAS PSIQUIATR
JI Rev. Bras. Psiquiatr.
PD MAR
PY 2010
VL 32
IS 1
BP 42
EP 46
DI 10.1590/S1516-44462010000100009
PG 5
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 572WI
UT WOS:000275864400009
PM 20339733
OA Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Tickell, AM
   Rohleder, C
   Ho, NI
   McHugh, C
   Jones, G
   Song, YJC
   Hickie, IB
   Scott, EM
AF Tickell, Ashleigh M.
   Rohleder, Cathrin
   Ho, Nicholas
   McHugh, Catherine
   Jones, Graham
   Song, Yun Ju Christine
   Hickie, Ian B.
   Scott, Elizabeth M.
TI Identifying pathways to early-onset metabolic dysfunction, insulin
   resistance and inflammation in young adult inpatients with emerging
   affective and major mood disorders
SO EARLY INTERVENTION IN PSYCHIATRY
LA English
DT Article
DE bipolar disorder; depression; insulin resistance; metabolic syndrome;
   mood disorders
ID HOMEOSTASIS MODEL ASSESSMENT; SEVERE MENTAL-ILLNESS; BIPOLAR DISORDER;
   PHYSICAL-ACTIVITY; DEPRESSION; RISK; SCHIZOPHRENIA; ANTIPSYCHOTICS;
   METAANALYSIS; ASSOCIATION
AB Aim Young people with common mood disorders face the prospect of shortened life expectancy largely due to premature cardiovascular disease. Metabolic dysfunction is a risk factor for premature cardiovascular disease. There is an ongoing debate whether metabolic dysfunction can be simply explained by weight gain secondary to psychotropic medications or whether shared genetic vulnerability, intrinsic immune-metabolic disturbances or other system perturbations (e.g. dysregulated sympathetic nervous system, circadian dysfunction) are more relevant determinants of premature cardiovascular disease. Thus, we aimed to investigate underlying drivers of metabolic dysfunction and premature cardiovascular disease in young people in the early phases of common mood disorders. Methods We evaluated the relationships between insulin resistance (assessed by HOMA2-IR) and body mass index (BMI), sex, diagnosis, medication, inflammatory markers and hormonal factors in 327 inpatients with emerging affective and major mood disorders admitted to the Young Adult Mental Health Unit, St Vincent's Private Hospital, Sydney. Results While HOMA2-IR scores were positively associated with BMI (r(s) = 0.465, p < .001), they were also higher in those prescribed mood stabilizers (p = .044) but were not associated with specific diagnoses, other medication types or the number of prescribed medications. Further, high-sensitivity C-reactive protein levels (but not thyroid-stimulating hormone and ferritin levels) were positively associated with HOMA2-IR (r(s) = 0. 272, p < .001) and BMI (r(s) = . 409, p < .001). Conclusions In addition to BMI, other non-specific markers of inflammation are associated with early metabolic dysfunction in young people with emerging affective and major mood disorders.
C1 [Tickell, Ashleigh M.; Rohleder, Cathrin; Ho, Nicholas; McHugh, Catherine; Song, Yun Ju Christine; Hickie, Ian B.; Scott, Elizabeth M.] Univ Sydney, Brain & Mind Ctr, 100 Mallett St, Camperdown, NSW 2050, Australia.
   [Jones, Graham] St Vincents Hosp, SydPath, Sydney, NSW, Australia.
   [Jones, Graham] Univ NSW, St Vincents Clin Sch, Kensington, NSW, Australia.
   [Scott, Elizabeth M.] St Vincents Private Hosp, Young Adult Mental Hlth Unit, Sydney, NSW, Australia.
C3 University of Sydney; NSW Health; St Vincents Hospital Sydney;
   University of New South Wales Sydney
RP Rohleder, C (corresponding author), Univ Sydney, Brain & Mind Ctr, 100 Mallett St, Camperdown, NSW 2050, Australia.
EM cathrin.rohleder@sydney.edu.au
RI Rohleder, Cathrin/AAD-2445-2019; Hickie, Ian/K-8975-2015
OI McHugh, Catherine/0000-0002-4891-4966; Hickie, Ian/0000-0001-8832-9895;
   Jones, Graham/0000-0001-9109-7255; Rohleder,
   Cathrin/0000-0002-3559-1846; Scott, Elizabeth/0000-0003-3907-0324
FU National Health & Medical Research Council Australia Fellowship
   [511921]; Bill & Patricia Ritchie Foundation
FX This work was partially supported by the National Health & Medical
   Research Council Australia Fellowship (No. 511921 awarded to Professor
   Hickie) and The Bill & Patricia Ritchie Foundation (awarded to Dr
   Tickell).
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NR 51
TC 6
Z9 6
U1 0
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1751-7885
EI 1751-7893
J9 EARLY INTERV PSYCHIA
JI Early Interv. Psychiatry
PD OCT
PY 2022
VL 16
IS 10
BP 1121
EP 1129
DI 10.1111/eip.13260
EA DEC 2021
PG 9
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 5B5JP
UT WOS:000724423600001
PM 34852406
DA 2025-06-11
ER

PT J
AU Khan, SR
AF Khan, S. R.
TI Stress oxidative: nephrolithiasis and chronic kidney diseases
SO MINERVA MEDICA
LA English
DT Article
DE Oxidative stress; Nephrolithiasis; Hypertension; Diabetes; Kidney
   failure; chronic; Metabolic syndrome; Atherosclerosis
ID MONOCYTE CHEMOATTRACTANT PROTEIN-1; SALT-SENSITIVE HYPERTENSION; RENAL
   EPITHELIAL-CELLS; NADPH OXIDASE; BLOOD-PRESSURE; NAD(P)H OXIDASE;
   ANGIOTENSIN-II; MESSENGER-RNA; OXALATE IONS; NITRIC-OXIDE
AB The association between nephrolithiasis and many chronic kidney diseases suggests a common causative link. There are indications that stone formation can lead to hypertension, diabetes, chronic disease and myocardial infarct. The reverse also appears to be true in that diabetes and hypertension can lead to stone formation. The production of reactive oxygen species (ROS) and the development of oxidative stress (OS) are common features of many renal and cardiovascular diseases including, hypertension, diabetes, metabolic syndrome and nephrolithiasis. It is my hypothesis that oxidative stress produced by one disease may lead to another under suitable conditions. For example mild hypercalciuria, hyperoxaluria, hypocitraturia which under normal conditions may just be a curiosity or nuisance can promote crystallization when cells are injured by ROS produced by the co-morbid condition. On the other hand OS produced during or as a result of nephrolithiasis may promote hypertension or diabetic nephropathy.
C1 [Khan, S. R.] Univ Florida, Coll Med, Dept Pathol, Gainesville, FL 32610 USA.
C3 State University System of Florida; University of Florida
RP Khan, SR (corresponding author), Univ Florida, Coll Med, Dept Pathol Immunol & Lab Med, Gainesville, FL 32610 USA.
EM khan@pathology.ufl.edu
FU NIDDK NIH HHS [R01-DK078602, R01 DK078602] Funding Source: Medline
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NR 70
TC 32
Z9 38
U1 0
U2 8
PU EDIZIONI MINERVA MEDICA
PI TURIN
PA CORSO BRAMANTE 83-85 INT JOURNALS DEPT., 10126 TURIN, ITALY
SN 0026-4806
EI 1827-1669
J9 MINERVA MED
JI Minerva Med.
PD FEB
PY 2013
VL 104
IS 1
BP 23
EP 30
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 127NM
UT WOS:000317705700002
PM 23392535
DA 2025-06-11
ER

PT J
AU Siegel, G
   Ermilov, E
   Pries, AR
   Winkler, K
   Schmidt, A
   Ringstad, L
   Malmsten, M
   Lindman, B
AF Siegel, Guenter
   Ermilov, Eugeny
   Pries, Axel R.
   Winkler, Karl
   Schmidt, Annette
   Ringstad, Lovisa
   Malmsten, Martin
   Lindman, Bjoern
TI The significance of lipid peroxidation in cardiovascular disease
SO COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
LA English
DT Article
DE Clinical trial; Ellipsometry; Ginkgo biloba; Metabolic syndrome;
   Biomarkers; Personalized medicine
ID ARTERIOSCLEROTIC NANOPLAQUE FORMATION; BIOMARKER PATTERN-ANALYSIS; COA
   REDUCTASE INHIBITORS; METABOLIC SYNDROME; OXIDATIVE STRESS;
   BLOOD-PRESSURE; ENDOTHELIAL DYSFUNCTION; PLASMA-LEVELS; LOW-DENSITY;
   IN-VIVO
AB Background: The metabolic syndrome describes a cluster of cardiovascular risk factors that frequently appear together. Its diagnosis is generally based on several well-recognized indicators in clinical practice, such as abdominal obesity, elevated triglycerides, reduced high-density lipoprotein, raised blood pressure, and elevated fasting plasma glucose. Today, decisive importance must be attached to the metabolic syndrome since it leads to increased morbidity and mortality, and thus to a decreased life expectancy, and to higher direct and indirect healthcare costs. This is also due to the fact that its symptomatology irradiates on many organs of the body, which may thereby be damaged.
   Methods: In the present clinical trial on 11 metabolic syndrome patients treated with Ginkgo biloba (EGb 761,2 x 120 mg/d) for two months, ellipsometry, fluorescence microscopy, photometric methods, ELISAs and EIAs were applied for biosensor profiling of metabolic syndrome risk, status and treatment outcome.
   Results: A spectrum of more than 20 arteriosclerotic, cytokinic, inflammatory, lipidic, and oxidative stress biomarkers served for a detailed diagnosis and therapy monitoring. After medication, the ratio oxLDL/LDL was reduced by 21.0%, 8-iso-PGF(2 alpha) 39.8%, MPO 29.6%, IL-6 12.9%, hs-CRP 39.3%, Lp(a) 26.3%, MMP-9 32.9%, insulin 9.4%, HOMA-IR 14.0%, ALP 14.8%, CREA 11.3%, URAC 10.6%, in vitro modeled nanoplaque formation 14.3% and size 23.4%, whereas SOD was augmented by 17.7%, GPx 11.6%, cAMP 43.5%, and cGMP 32.9%. Special focus was concentrated on the significance of lipid peroxidation for cardio-cerebro-vascular diseases. Through multiple correlations between the biomarkers and clinical parameters, their significance for and involvement in several clinical pictures could be elucidated.
   Conclusion:The present clinical observational study was helpful in unraveling this network of biomarker interactions and demonstrated its usefulness for theranostics. For personalized medicine, the selection of the biomarkers is of decisive importance. On the background of a growing obesity among children and adolescents with an increase in prevalence of the metabolic syndrome, diagnosing this syndrome in young subjects may be helpful in identifying a population of risk for increased subclinical arteriosclerosis. (C) 2013 Elsevier B.V. All rights reserved.
C1 [Siegel, Guenter; Ermilov, Eugeny; Pries, Axel R.; Malmsten, Martin] Charite Univ Clin Berlin, Inst Physiol, D-10117 Berlin, Germany.
   [Siegel, Guenter; Malmsten, Martin] Uppsala Univ, Biomed Ctr, Dept Pharm, S-75123 Uppsala, Sweden.
   [Winkler, Karl] Univ Clin Freiburg, Inst Clin Chem, D-79106 Freiburg, Germany.
   [Schmidt, Annette] Univ Munster, Leibniz Inst Arteriosclerosis Res, D-48149 Munster, Germany.
   [Ringstad, Lovisa] Inst Surface Chem, Ytkemiska Inst, S-11486 Stockholm, Sweden.
   [Lindman, Bjoern] Lund Univ, S-22100 Lund, Sweden.
   [Lindman, Bjoern] Univ Coimbra, Dept Chem, P-3004535 Coimbra, Portugal.
C3 Berlin Institute of Health; Free University of Berlin; Humboldt
   University of Berlin; Charite Universitatsmedizin Berlin; Uppsala
   University; University of Freiburg; University of Munster; Lund
   University; Universidade de Coimbra
RP Siegel, G (corresponding author), Charite Univ Clin Berlin, Inst Physiol, Charitepl 1, D-10117 Berlin, Germany.
EM guenter.siegel@charite.de
RI Martin, Alma/Q-1794-2017
OI Ermilov, Eugeny/0000-0003-3679-9996; Lindman, Bjorn/0000-0002-7493-9112
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NR 52
TC 12
Z9 12
U1 0
U2 22
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0927-7757
EI 1873-4359
J9 COLLOID SURFACE A
JI Colloid Surf. A-Physicochem. Eng. Asp.
PD FEB 1
PY 2014
VL 442
SI SI
BP 173
EP 180
DI 10.1016/j.colsurfa.2013.05.022
PG 8
WC Chemistry, Physical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry
GA AB3JL
UT WOS:000331687000024
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Anraku, M
   Gebicki, JM
   Iohara, D
   Tomida, H
   Uekama, K
   Maruyama, T
   Hirayama, F
   Otagiri, M
AF Anraku, Makoto
   Gebicki, Janusz M.
   Iohara, Daisuke
   Tomida, Hisao
   Uekama, Kaneto
   Maruyama, Toru
   Hirayama, Fumitoshi
   Otagiri, Masaki
TI Antioxidant activities of chitosans and its derivatives in in
   vitro and in vivo studies
SO CARBOHYDRATE POLYMERS
LA English
DT Review
DE Chitosan; Antioxidant; Renal failure; Oxidative stress; Nanofibers
ID CHRONIC KIDNEY-DISEASE; LOW-MOLECULAR-WEIGHT; BOUND UREMIC TOXINS;
   OXIDATIVE STRESS; INDOXYL SULFATE; RENAL-FAILURE; CARBOXYMETHYL
   CHITOSAN; NEPHRECTOMIZED RATS; CHITIN NANOFIBRILS; METABOLIC SYNDROME
AB This review focuses on the in vitro and in vivo antioxidant activities of various chitosan preparations, including those with different molecular weights and degrees of acetylation and the nanofibers produced from them. In in vitro studies, low molecular weight (LMW) chitosan with high degrees of deacetylation has more potent antioxidant properties than those of high molecular weight (HMW) chitosan. On the other hand, HMW chitosan has higher adsorption properties than those of LMW chitosan. On the basis of the in vitro results obtained, the ingestion of chitosan and nanofiber derived from it, with moderate MW and degrees of acetylation results in a significant reduction in oxidative stress in several chronic oxidative stress related diseases such as the metabolic syndrome and renal failure. In the future, chitosan and related nanofibers with presumed antioxidant properties may be used as a new source of antioxidant, as a possible food supplement, as an ingredient or in the pharmaceutical industry.
C1 [Anraku, Makoto; Iohara, Daisuke; Uekama, Kaneto; Hirayama, Fumitoshi; Otagiri, Masaki] Sojo Univ, Fac Pharmaceut Sci, Nishi Ku, 4-22-1 Ikeda, Kumamoto 8600082, Japan.
   [Anraku, Makoto; Iohara, Daisuke; Hirayama, Fumitoshi; Otagiri, Masaki] Sojo Univ, DDS Res Inst, Nishi Ku, 4-22-1 Ikeda, Kumamoto 8600082, Japan.
   [Gebicki, Janusz M.] Macquarie Univ, Dept Biol Sci, Sydney, NSW 2109, Australia.
   [Tomida, Hisao] Fukuyama Univ, Fac Pharm & Pharmaceut Sci, Sanzo 1,Gakuen Cho, Fukuyama, Hiroshima 7290292, Japan.
   [Maruyama, Toru] Kumamoto Univ, Grad Sch Pharmaceut Sci, 5-1 Oe Honmachi, Kumamoto 8620973, Japan.
C3 Sojo University; Sojo University; Macquarie University; Fukuyama
   University; Kumamoto University
RP Anraku, M (corresponding author), Sojo Univ, Fac Pharmaceut Sci, 4-22-1 Ikeda, Kumamoto 8600082, Japan.
EM anraku@ph.sojo-u.ac.jp
RI Anraku, Makoto/AAA-3935-2020; Maruyama, Toru/NFS-8627-2025
OI Anraku, Makoto/0000-0001-8249-6983
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NR 94
TC 115
Z9 120
U1 7
U2 113
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0144-8617
EI 1879-1344
J9 CARBOHYD POLYM
JI Carbohydr. Polym.
PD NOV 1
PY 2018
VL 199
BP 141
EP 149
DI 10.1016/j.carbpol.2018.07.016
PG 9
WC Chemistry, Applied; Chemistry, Organic; Polymer Science
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Polymer Science
GA GR1XK
UT WOS:000442348500016
PM 30143114
DA 2025-06-11
ER

PT J
AU Oladeji, BD
   Gureje, O
AF Oladeji, Bibilola D.
   Gureje, Oye
TI The Comorbidity between Depression and Diabetes
SO CURRENT PSYCHIATRY REPORTS
LA English
DT Article
DE Depression; Diabetes; Comorbidity; Epidemiology; Bidirectional
   associations; Risk factors; Disability; Diabetes outcomes; Incident
   diabetes; Incident depression; Antidepressant medications; Metabolic
   syndrome; Insulin resistance; Brain dysfunctions; Glycaemic control;
   Diabetes complications; Diabetes related costs; Psychological
   interventions; Collaborative care; Incidence; Longitudinal studies;
   Psychiatry
ID CO-MORBID DEPRESSION; CHRONIC SOMATIC DISEASES; COMMON MENTAL-DISORDERS;
   GLYCEMIC CONTROL; RISK-FACTOR; BIDIRECTIONAL ASSOCIATION; INFLAMMATORY
   DISEASE; GLUCOSE-METABOLISM; MAJOR DEPRESSION; OUT-PATIENTS
AB Comorbidity of depression and diabetes is common, and each disorder has a negative impact on the outcome of the other. The direction of causality is not certain as each disorder seems to act as both a risk factor and consequence for the other in longitudinal studies. This bidirectional association is possibly mediated by shared environmental and genetic risk factors. Comorbid depression is associated with reduced adherence to medication and self-care management, poor glycaemic control, increased health care utilization, increased costs and elevated risk of complications, as well as mortality in patients with diabetes. Psychological and pharmacological interventions are shown to be effective in improving depression symptoms; however, collaborative care programs that simultaneously manage both disorders seem to be most effective in improving diabetes-related outcomes.
C1 [Oladeji, Bibilola D.; Gureje, Oye] Univ Ibadan, Coll Med, Dept Psychiat, Ibadan, Nigeria.
C3 University of Ibadan
RP Oladeji, BD (corresponding author), Univ Ibadan, Coll Med, Dept Psychiat, Ibadan, Nigeria.
EM bibideji@yahoo.com
RI Oladeji, Bibilola/AAG-9068-2020; Gureje, Oye/J-1183-2014
OI Oladeji, Bibilola/0000-0001-5856-2100; Gureje, Oye/0000-0003-0094-5947
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NR 88
TC 36
Z9 44
U1 1
U2 48
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1523-3812
EI 1535-1645
J9 CURR PSYCHIAT REP
JI Curr. Psychiatry Rep.
PD SEP
PY 2013
VL 15
IS 9
AR 390
DI 10.1007/s11920-013-0390-3
PG 8
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 208DI
UT WOS:000323656400005
PM 23933977
DA 2025-06-11
ER

PT J
AU Wang, W
   Ding, XQ
   Gu, TT
   Song, L
   Li, JM
   Xue, QC
   Kong, LD
AF Wang, Wei
   Ding, Xiao-Qin
   Gu, Ting-Ting
   Song, Lin
   Li, Jian-Mei
   Xue, Qiao-Chu
   Kong, Ling-Dong
TI Pterostilbene and allopurinol reduce fructose-induced podocyte oxidative
   stress and inflammation via microRNA-377
SO FREE RADICAL BIOLOGY AND MEDICINE
LA English
DT Article
DE Pterostilbene; Allopurinol; MiR-377; Fructose; Oxidative stress;
   Podocyte injury; TXNIP; NLRP3 inflammasome; Free radicals
ID THIOREDOXIN-INTERACTING PROTEIN; SERUM URIC-ACID; LIPID-ACCUMULATION;
   ENDOTHELIAL-CELLS; CHRONIC KIDNEY; RENAL-DISEASE; INJURY; ACTIVATION;
   EXPRESSION; GLUCOSE
AB High dietary fructose is an important causative factor in the development of metabolic syndrome-associated glomerular podocyte oxidative stress and injury. Here, we identified microRNA-377 (miR-377) as a biomarker of oxidative stress in renal cortex of fructose-fed rats, which correlated with podocyte injury and albuminuria in metabolic syndrome. Fructose feeding increased miR-377 expression, decreased superoxide dismutase (SOD) expression and activity, and caused O-2(-) and H2O2 overproduction in kidney cortex or glomeruli of rats. This reactive oxygen species induction increased p38 MAPK phosphorylation and thioredoxin-interacting protein (TXNIP) expression and activated the NOD-like receptor pyrin domain-containing 3 (NLRP3) inflammasome to produce interleukin-1 beta in kidney glomeruli of fructose-fed rats. These pathological processes were further evaluated in cultured differentiated podocytes exposed to 5 mM fructose, or transfected with miR-377 mimic/inhibitor and TXNIP siRNA, or co-incubated with p38 MAPK inhibitor, demonstrating that miR-377 overexpression activates the O-2(-)/p38 MAPK/TXNIP/NLRP3 inflammasome pathway to promote oxidative stress and inflammation in fructose-induced podocyte injury. Antioxidants pterostilbene and allopurinol were found to ameliorate fructose-induced hyperuricemia, podocyte injury, and albuminuria in rats. More importantly, pterostilbene and allopurinol inhibited podocyte miR-377 overexpression to increase SOD1 and SOD2 levels and suppress the O-2(-)/p38 MAPK/TXNIP/NLRP3 inflammasome pathway activation in vivo and in vitro, consistent with the reduction of oxidative stress and inflammation. These findings suggest that miR-377 plays an important role in glomerular podocyte oxidative stress, inflammation, and injury driven by high fructose. Inhibition of miR-377 by antioxidants may be a promising therapeutic strategy for the prevention of metabolic syndrome-associated glomerular podocyte injury. (C) 2015 Elsevier Inc. All rights reserved.
C1 [Wang, Wei; Ding, Xiao-Qin; Gu, Ting-Ting; Song, Lin; Li, Jian-Mei; Xue, Qiao-Chu; Kong, Ling-Dong] Nanjing Univ, Sch Life Sci, State Key Lab Pharmaceut Biotechnol, Nanjing 210023, Jiangsu, Peoples R China.
C3 Nanjing University
RP Kong, LD (corresponding author), Nanjing Univ, Sch Life Sci, State Key Lab Pharmaceut Biotechnol, Nanjing 210023, Jiangsu, Peoples R China.
EM kongld@nju.edu.cn
RI w, w/J-6981-2019
FU National Basic Research Program of China 973 Program [2012CB517600,
   2012CB517602]; Natural Science Foundation of China [81025025, J1210026];
   Ph.D. Programs Foundation of the Ministry of Education of China
   [20120091110039]
FX The authors thank Professor Zhi-Hong Liu for valuable advice and help in
   experiments and constructive criticism of the manuscript. We thank Dr,
   Wei-Song Qin and Dr. Shao-Lin Shi for excellent technical assistance in
   cell culture. This study was supported by grants from the National Basic
   Research Program of China 973 Program No. 2012CB517600 (No.
   2012CB517602) and the Natural Science Foundation of China (Nos. 81025025
   and J1210026). Further support was obtained from the Ph.D. Programs
   Foundation of the Ministry of Education of China (20120091110039).
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NR 63
TC 146
Z9 154
U1 3
U2 70
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0891-5849
EI 1873-4596
J9 FREE RADICAL BIO MED
JI Free Radic. Biol. Med.
PD JUN
PY 2015
VL 83
BP 214
EP 226
DI 10.1016/j.freeradbiomed.2015.02.029
PG 13
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA CJ6BI
UT WOS:000355577600021
PM 25746774
DA 2025-06-11
ER

PT J
AU Meigs, JB
   Larson, MG
   Fox, CS
   Keaney, JF
   Vasan, RS
   Benjamin, EJ
AF Meigs, James B.
   Larson, Martin G.
   Fox, Caroline S.
   Keaney, John F., Jr.
   Vasan, Ramachandran S.
   Benjamin, Emelia J.
TI Association of oxidative stress, insulin resistance, and diabetes risk
   phenotypes - The framingham offspring study
SO DIABETES CARE
LA English
DT Article
ID ACTIVATED SIGNALING PATHWAYS; ENDOTHELIAL DYSFUNCTION; METABOLIC
   SYNDROME; LIPID-PEROXIDATION; GLUCOSE; MARKERS; MYELOPEROXIDASE;
   OBESITY; PROTEIN; MEN
AB OBJECTIVE - Systemic oxidative stress causes insulin resistance in rodents. We tested the hypothesis that oxidative stress and insulin resistance are associated in humans.
   RESEARCH DESIGN AND METHODS - We used cross-sectional data from 2,002 nondiabetic subjects of the community-based Framingham Offspring Study. We measured insulin resistance with the homeostasis model and defined categorical insulin resistance as oxidative stress using the ratio of urine 8-epi-prostaglandin F-2 alpha (8-epi-PGF(2 alpha)) to creatinine and used age- and sex-adjusted regression models to test the association of oxidative stress with insulin resistance in individuals without diabetes and among subgroups at elevated risk of diabetes.
   RESULTS - Across 8-epi-PGF(2 alpha)/creatinine tertiles, the prevalence of insulin resistance increased (18.0 and 29.4% for the first, second, and third tertiles, respectively; P < 0.0001), as did mean levels of HOMA-IR (3.28,3.83, and 4.06 units; P < 0.0001). The insulin resistanceoxidative stress association was attenuated by additional adjustment for BMI (P = 0.06 across tertiles for insulin resistance prevalence; P = 0.004 for mean HOMA-IR). Twenty-six percent of participants were obese (BMI :30 kg/m(2)), 39% had metabolic syndrome (according to the Adult Treatment Panel III definition), and 37% had impaired fasting glucose (IFG) (fasting glucose 5.6-6.9 mmol/l). Among 528 obese participants, respectively, insulin resistance prevalence was 41.3, 60.6, and 54.2% across 8-epi-PGF(2 alpha)/creatinine tertiles (P = 0.005); among 781 subjects with metabolic syndrome, insulin resistance prevalence was 41.3, 56.7, and 51.7% (P = 0.0025); and among 749 subjects with IFG, insulin resistance prevalence was 39.6, 47.2, and 51.6% (P = 0.04).
   CONCLUSIONS - Systemic oxidative stress is associated with insulin resistance in individuals at average or elevated risk of diabetes even after accounting for BMI.
C1 Harvard Med Sch, Massachusetts Gen Hosp, Dept Med, Boston, MA USA.
   Boston Univ, Dept Math & Stat, Boston, MA USA.
   Natl Heart Lung Blood Inst, Framingham Heart Study, Framingham, MA USA.
   Harvard Med Sch, Brigham & Womens Hosp, Div Endocrinol Diabet & Hypertens, Boston, MA USA.
   Univ Massachusetts, Sch Med, Div Cardiovasc Med, Worcester, MA USA.
   Whitaker Cardiovasc Inst, Evans Dept Med, Boston, MA USA.
   Boston Univ, Sch Med, Prevent Med Sect, Boston, MA USA.
C3 Harvard University; Harvard Medical School; Harvard University Medical
   Affiliates; Massachusetts General Hospital; Boston University;
   Framingham Heart Study; National Institutes of Health (NIH) - USA; NIH
   National Heart Lung & Blood Institute (NHLBI); Harvard University;
   Harvard Medical School; Harvard University Medical Affiliates; Brigham &
   Women's Hospital; University of Massachusetts System; University of
   Massachusetts Worcester; Boston University
RP Meigs, JB (corresponding author), Massachusetts Gen Hosp, Div Gen Med, 50 Staniford St,9th Floor, Boston, MA 02114 USA.
EM jmeigs@partners.org
RI Ramachandran, Vasan/Y-2527-2019; Meigs, James/P-3927-2019; Benjamin,
   Emelia/E-7103-2011
OI Larson, Martin/0000-0002-9631-1254; Benjamin,
   Emelia/0000-0003-4076-2336; Keaney, John/0000-0002-0866-1837;
   Ramachandran, Vasan/0000-0001-7357-5970
FU NHLBI NIH HHS [N01 HV 28178, N01-HC-25195, HL64753, HL076784, HL71039,
   2K24-HL-04334] Funding Source: Medline; NIA NIH HHS [AG028321] Funding
   Source: Medline
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NR 47
TC 184
Z9 222
U1 0
U2 8
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0149-5992
EI 1935-5548
J9 DIABETES CARE
JI Diabetes Care
PD OCT
PY 2007
VL 30
IS 10
BP 2529
EP 2535
DI 10.2337/dc07-0817
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 221JN
UT WOS:000250223400022
PM 17586736
OA Bronze
DA 2025-06-11
ER

PT J
AU Kiecolt-Glaser, JK
AF Kiecolt-Glaser, Janice K.
TI Marriage, Divorce, and the Immune System
SO AMERICAN PSYCHOLOGIST
LA English
DT Article
DE marriage; gut microbiome; depression; inflammation; interdependence
ID HEART-RATE-VARIABILITY; HIGH-FAT MEALS; MARITAL QUALITY; INFLAMMATORY
   RESPONSES; DEPRESSIVE SYMPTOMS; METABOLIC SYNDROME; MAJOR DEPRESSION;
   PAST DEPRESSION; RELATIONSHIP BEHAVIOR; LIFE-STYLE
AB This article reviews evidence from several lines of work to describe how marriage and divorce can provoke health-relevant immune alterations, including ways that marital closeness can be perilous for health and divorce can be beneficial. The multiple stresses of a troubled relationship are depressogenic, and the development of a mood disorder sets the stage for psychological and biological vulnerability. Depression provides a central pathway to immune dysregulation, inflammation, and poor health; gender-related differences in depression and inflammation can heighten risk for women compared to men. Sleep and obesity can simultaneously feed off depression as they promote it. In addition, spousal similarities in health behaviors, gene expression, immune profiles and the gut microbiota offer new ways to consider the health advantages and risks of marriage and divorce, providing new perspectives on couples' interdependence, as well as new directions for research.
C1 [Kiecolt-Glaser, Janice K.] Ohio State Univ, Coll Med, Inst Behav Med Res, 460 Med Ctr Dr, Columbus, OH 43210 USA.
C3 University System of Ohio; Ohio State University
RP Kiecolt-Glaser, JK (corresponding author), Ohio State Univ, Coll Med, Inst Behav Med Res, 460 Med Ctr Dr, Columbus, OH 43210 USA.
EM Janice.Kiecolt-Glaser@osumc.edu
FU National Institutes of Health [K05 CA172296, R01 CA186720, R01 CA186251,
   R01 AG057032]
FX Work on this article was supported in part by National Institutes of
   Health Grants K05 CA172296, R01 CA186720, R01 CA186251, and R01
   AG057032.
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NR 105
TC 73
Z9 91
U1 2
U2 34
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 0003-066X
EI 1935-990X
J9 AM PSYCHOL
JI Am. Psychol.
PD DEC
PY 2018
VL 73
IS 9
BP 1098
EP 1108
DI 10.1037/amp0000388
PG 11
WC Psychology, Multidisciplinary
WE Social Science Citation Index (SSCI)
SC Psychology
GA HD3OL
UT WOS:000452426700006
PM 30525786
OA Green Accepted, hybrid
DA 2025-06-11
ER

PT J
AU Holt, EW
   Wei, EK
   Bennett, N
   Zhang, LM
AF Holt, Edward W.
   Wei, Esther K.
   Bennett, Nancy
   Zhang, Laura M.
TI Low skin carotenoid concentration measured by resonance Raman
   spectroscopy is associated with metabolic syndrome in adults
SO NUTRITION RESEARCH
LA English
DT Article
DE Skin carotenoids; Resonance Raman spectroscopy; Antioxidant; Obesity;
   Metabolic syndrome
ID NUTRITION EXAMINATION SURVEY; NONALCOHOLIC FATTY LIVER; OXIDATIVE
   STRESS; CARDIOVASCULAR-DISEASE; VEGETABLE INTAKE; NATIONAL-HEALTH; RISK;
   ANTIOXIDANTS; FRUIT; POPULATION
AB Oxidative stress is increased in patients with metabolic syndrome (MS). Antioxidants, including carotenoids, are decreased in MS. We hypothesized that a low skin carotenoid score (SCS), calculated using resonance Raman spectroscopy, would correlate with the presence of MS. We retrospectively reviewed consecutive patients referred for dietary assessment between 2010 and 2012. For each patient, a nutrition history, medical history, and SCS were recorded. chi(2) and Student t test were used to determine factors associated with MS. Multivariate logistic regression was used to identify factors associated with MS. One hundred fifty-five patients were included. The mean age was 54.1 +/- 13.1 years, and the mean body mass index was 28.3 +/- 6.1 kg/m(2). Metabolic syndrome was present in 43.9% of patients. The mean SCS was 28 084 +/- 14 006 Raman counts (RC), including 23 058 +/- 9812 RC for patients with MS and 32 011 +/- 15 514 RC for patients without MS (P = .0001). In a multivariate analysis, SCS less than 25 000 RC (odds ratio, 3.71; 95% confidence interval, 1.36-10.7; P = .01) was independently associated with MS. A higher number of MS components was associated with a progressively lower SCS (P = .004). In a consecutive sample of patients referred for dietary assessment, a noninvasively measured SCS was lower among patients with MS. (C) 2014 Elsevier Inc. All rights reserved.
C1 [Holt, Edward W.] Calif Pacific Med Ctr, Div Hepatol, Dept Transplantat, San Francisco, CA 94115 USA.
   [Wei, Esther K.] Calif Pacific Med Ctr, Res Inst, San Francisco, CA 94115 USA.
   [Bennett, Nancy] Calif Pacific Med Ctr, Dept Nutr, San Francisco, CA 94115 USA.
   [Zhang, Laura M.] Calif Pacific Med Ctr, Dept Med, San Francisco, CA 94115 USA.
C3 California Pacific Medical Center; California Pacific Medical Center;
   California Pacific Medical Center Research Institute; California Pacific
   Medical Center; California Pacific Medical Center
RP Holt, EW (corresponding author), Calif Pacific Med Ctr, 2340 Clay St,Room 312, San Francisco, CA 94115 USA.
EM holte@sutterhealth.org
CR [Anonymous], NATL HLTH STAT REPOR
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NR 43
TC 15
Z9 17
U1 0
U2 22
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0271-5317
J9 NUTR RES
JI Nutr. Res.
PD OCT
PY 2014
VL 34
IS 10
BP 821
EP 826
DI 10.1016/j.nutres.2014.08.017
PG 6
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA AS0IE
UT WOS:000343960300001
PM 25249018
DA 2025-06-11
ER

PT J
AU Manzanares, N
   Monseny, R
   Ortega, L
   Montalvo, L
   Franch, J
   Gutiérrez-Zotes, A
   Reynolds, RM
   Walker, BR
   Vilella, E
   Labad, J
AF Manzanares, Nuria
   Monseny, Rosa
   Ortega, Laura
   Montalvo, Ltziar
   Franch, Joan
   Gutierrez-Zotes, Alfonso
   Reynolds, Rebecca M.
   Walker, Brian R.
   Vilella, Elisabet
   Labad, Javier
TI Unhealthy lifestyle in early psychoses: The role of life stress and the
   hypothalamic-pituitary-adrenal axis
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE Stress; Cortisol; Diet; Obesity; Metabolic syndrome; Schizophrenia;
   Psychoses; High risk; At-risk mental states
ID VISCERAL FAT DISTRIBUTION; DRUG-NAIVE PATIENTS; SALIVARY CORTISOL;
   WEIGHT-GAIN; METABOLIC SYNDROME; 1ST EPISODE; SCHIZOPHRENIA; DIETARY;
   PATTERN; EVENTS
AB An unhealthy lifestyle is thought to contribute to the metabolic syndrome in subjects with psychoses. In the present study we aimed to study whether life stress or cortisol measures may influence dietary patterns in subjects with early stages of psychoses. We studied 81 subjects with early psychoses (65 subjects with a psychotic disorder [PD] and <5 years of illness; 16 subjects at risk for psychosis [high-risk, HR]) and a control group of 25 healthy subjects (HS). Dietary habits were examined by a dietician, who registered food intake (24 h recall). Physical activity was assessed by validated questionnaire. Life stress was assessed with Holmes-Rahe Social Readjustment Scale. Fasting morning salivary and plasma cortisol levels were determined. We found that PD and HR reported an unhealthier lifestyle with more smoking, reduced physical activity and poorer dietary habits. HR reported increased intake of calories and saturated fatty acids and reduced protein consumption, when compared to HS. Life stress was a predictor of these adverse behaviours, although we found opposite associations in HR and PD. Life stress was associated with increased intake of refined sugar in PD and decreased intake in HR and HS. Salivary cortisol was related to increased intake of saturated fat only in HR subjects, but cortisol levels in plasma or saliva were not associated with other dietary habits or obesity measures (BMI, waist circumference). Our study suggests that unhealthy diet in early psychoses is influenced by stress, but our data do not support this effect being mediated by hypercortisolism. Future preventive interventions in psychosis may target dietary habits, particularly for those who are at risk for psychosis. (C) 2013 Elsevier Ltd. All rights reserved.
C1 [Manzanares, Nuria; Monseny, Rosa; Ortega, Laura; Montalvo, Ltziar; Franch, Joan; Gutierrez-Zotes, Alfonso; Vilella, Elisabet; Labad, Javier] Univ Rovira & Virgili, IISPV, HPU Inst Pere Mata, Early Psychosis Program & Res Dept,CIBERSAM, E-43201 Reus, Spain.
   [Reynolds, Rebecca M.; Walker, Brian R.] Univ Edinburgh, Queens Med Res Inst, Univ BHF Ctr Cardiovasc Sci, Endocrinol Unit, Edinburgh, Midlothian, Scotland.
C3 Universitat Rovira i Virgili; Institut d'Investigacio Sanitaria Pere
   Virgili (IISPV); CIBER - Centro de Investigacion Biomedica en Red;
   CIBERSAM; University of Edinburgh
RP Labad, J (corresponding author), Hosp Univ Inst Pere Mata, Early Psychosis Program & Res Dept, Ctra Inst Pere Mata S-N, Reus 43206, Spain.
EM labadj@peremata.com
RI Labad, Javier/AAF-6632-2020; Ortega, Laura/M-7042-2019; Vilella,
   Elisabet/HII-9781-2022; Reynolds, Rebecca M/C-3044-2008
OI Ortega, Laura/0000-0003-2476-7700; Labad, Javier/0000-0003-2214-1886;
   Reynolds, Rebecca M/0000-0001-6226-8270; Montalvo,
   Itziar/0000-0002-7320-5109
FU Fundacio La Marato de TV3 [092230/0922431]; Instituto de Salud Carlos
   III (FIS) [PI10/01607]; Instituto de Salud Carlos III (Spain)
   [I3SNS-INT11/323]
FX This work was supported by grants from Fundacio La Marato de TV3
   (092230/0922431) and from Instituto de Salud Carlos III (FIS,
   PI10/01607). Javier Labad has received an Intensification of Research
   Activity grant (Programme I3SNS-INT11/323) from the Instituto de Salud
   Carlos III (Spain) during 2012 and 2013.
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NR 41
TC 39
Z9 43
U1 0
U2 25
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD JAN
PY 2014
VL 39
BP 1
EP 10
DI 10.1016/j.psyneuen.2013.09.023
PG 10
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA AA0WM
UT WOS:000330818100001
PM 24274999
DA 2025-06-11
ER

PT J
AU Liu, LP
   Wariboko, MA
   Hu, X
   Wang, ZH
   Wu, Q
   Li, YM
AF Liu, Li-Ping
   Wariboko, Mary Adumo
   Hu, Xiao
   Wang, Zi-Han
   Wu, Qian
   Li, Yu-Mei
TI Factors associated with early-onset androgenetic alopecia: A scoping
   review
SO PLOS ONE
LA English
DT Article
ID MALE PATTERN BALDNESS; METABOLIC SYNDROME; INSULIN-RESISTANCE;
   RISK-FACTORS; MEN; WOMEN; CLASSIFICATION; HYPERTENSION; AROMATASE;
   SEVERITY
AB Background Early-onset androgenetic alopecia (AGA) has been associated with various chronic conditions, including metabolic syndrome (MetS). Gaining a deep understanding of early-onset AGA may enable earlier intervention in individuals at high risks. This scoping review aims to explore the risk factors and etiology, associated conditions, and adverse effects on wellbeing in early-onset AGA.Methods Electronic literature searches were conducted in MEDLINE, EMBASE and CENTRIAL. Eligible studies included case-control, cohort, cross-sectional, and meta-analysis studies. Selected studies needed to clearly define early-onset AGA cases or include only cases starting before the age of 40 and compare them with appropriate controls. The exclusion criteria comprised editorials, commentaries, case series, and non-systematic reviews, among others. Data extraction involved collecting study characteristics, methodologies, main outcomes, and findings. Descriptive tables were used to summarize key information and relevant variables when necessary.Results Among the 65 eligible articles, 67.69% were case-control studies and 78.46% evaluated only male patients. "Early-onset" was defined as cases developing before the age of 30 years in 43.08% of the studies. The Hamilton-Norwood scale was the most frequently used method for evaluating the severity of alopecia in men (69.23%). Reported risk factors for early-onset AGA included a family history of AGA, cigarette smoking, unhealthy dietary habits, and a high body mass index. Early-onset AGA may also be associated with hormonal profiles, 5 alpha-reductase enzyme activity, androgen receptor genes, and some susceptibility loci. Comorbidities investigated included MetS, cardiovascular disease, insulin resistance, dyslipidemia, and Parkinson's disease. Men with early-onset AGA may have reduced treatment efficacy with drug like rosuvastatin, metformin or lisinopril for dyslipidemia, prediabetes, or hypertension. Additionally, young men with AGA tended to suffer from psychological issues such as anxiety and low self-esteem compared to those without hair loss.Conclusion Early-onset AGA is a complex condition with various risk factors and etiology, associated comorbidities, and potential implications for treatment response and psychological health.
C1 [Liu, Li-Ping; Wariboko, Mary Adumo; Wang, Zi-Han; Wu, Qian; Li, Yu-Mei] Jiangsu Univ, Affiliated Hosp, Dept Dermatol, Zhenjiang, Jiangsu, Peoples R China.
   [Liu, Li-Ping; Wariboko, Mary Adumo; Wang, Zi-Han; Wu, Qian; Li, Yu-Mei] Jiangsu Univ, Inst Regenerat Med, Zhenjiang, Jiangsu, Peoples R China.
   [Hu, Xiao] First Peoples Hosp Zhenjiang, Dept Urol, Zhenjiang, Jiangsu, Peoples R China.
C3 Jiangsu University; Jiangsu University
RP Liu, LP; Li, YM (corresponding author), Jiangsu Univ, Affiliated Hosp, Dept Dermatol, Zhenjiang, Jiangsu, Peoples R China.; Liu, LP; Li, YM (corresponding author), Jiangsu Univ, Inst Regenerat Med, Zhenjiang, Jiangsu, Peoples R China.
EM liuliping@ujs.edu.cn; l.yumei@aliyun.com
RI Liu, Li-Ping/ADB-6833-2022; Li, Yumei/LTK-6197-2024
FU National Natural Science Foundation of China [82103766]; Jiangsu
   Provincial Medical Key Discipline Cultivation Unit [JSDW202229]
FX This research was funded partly by the National Natural Science
   Foundation of China (82103766 to L.-P.L.) and Jiangsu Provincial Medical
   Key Discipline Cultivation Unit (JSDW202229 to Y.-M.L.). No sponsor or
   funder play any role in the study design, data collection and analysis,
   decision to publish, or preparation of the manuscript.
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NR 81
TC 9
Z9 9
U1 6
U2 11
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAR 7
PY 2024
VL 19
IS 3
AR e0299212
DI 10.1371/journal.pone.0299212
PG 18
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA KR5Y9
UT WOS:001181719200063
PM 38451966
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Kishi, T
   Hirooka, Y
   Nagayama, T
   Isegawa, K
   Katsuki, M
   Takesue, K
   Sunagawa, K
AF Kishi, Takuya
   Hirooka, Yoshitaka
   Nagayama, Tomomi
   Isegawa, Kengo
   Katsuki, Masato
   Takesue, Ko
   Sunagawa, Kenji
TI Calorie Restriction Improves Cognitive Decline via Up-Regulation of
   Brain-Derived Neurotrophic Factor Tropomyosin-Related Kinase B in
   Hippocampus of Obesity-Induced Hypertensive Rats
SO INTERNATIONAL HEART JOURNAL
LA English
DT Article
DE Metabolic syndrome; Cognition
ID ROSTRAL VENTROLATERAL MEDULLA; RANDOMIZED CONTROLLED-TRIAL; METABOLIC
   SYNDROME; OXIDATIVE STRESS; KNOCKOUT MICE; ADULT-RATS; TELMISARTAN;
   EXPRESSION; EXERCISE; RECEPTOR
AB In metabolic syndrome (MetS), previous studies have suggested that cognitive decline is worsened. Among the factors associated with cognition, decreased brain-derived neurotrophic factor (BDNF) in the hippocampus causes cognitive decline. We previously reported that exercise training with calorie restriction yielded protection against cognitive decline via BDNF in the hippocampus of hypertensive rats. The aim of the present study was to determine whether or not calorie restriction results in protection against cognitive decline via BDNF and its receptor tropomyosin-related kinase B (TrkB) in the hippocampus of MetS model rats. We divided dietary-induced obesity-prone and hypertensive rats (OP), as metabolic syndrome model rats, into three groups, fed with a high fat diet (HF), treated with calorie restriction (CR) plus vehicle, and treated with CR and ANA-12 (a TrkB antagonist) (CR+A). After treatment for 28 days, body weight, insulin, fasting blood glucose, adiponectin, systolic blood pressure, and oxidative stress in the hippocampus were significantly lower, and BDNF expression in the hippocampus was significantly higher in CR and CR+A than in HF. Cognitive performance determined by the Morris water maze test was significantly higher in CR than in HF, whereas the benefit was attenuated in CR+A. In conclusion, calorie restriction protects against cognitive decline via up-regulation of BDNF/TrkB through an antioxidant effect in the hippocampus of dietary-induced obesity rats.
C1 [Kishi, Takuya] Kyushu Univ, Grad Sch Med Sci, Dept Adv Therapeut Cardiovasc Dis, Fukuoka 8128582, Japan.
   [Hirooka, Yoshitaka] Kyushu Univ, Grad Sch Med Sci, Dept Adv Cardiovasc Regulat & Therapeut, Fukuoka 8128582, Japan.
   [Nagayama, Tomomi; Isegawa, Kengo; Katsuki, Masato; Takesue, Ko; Sunagawa, Kenji] Kyushu Univ, Grad Sch Med Sci, Dept Cardiovasc Medi, Fukuoka 8128582, Japan.
C3 Kyushu University; Kyushu University; Kyushu University
RP Kishi, T (corresponding author), Kyushu Univ, Grad Sch Med Sci, Dept Adv Therapeut Cardiovasc Dis, Higashi Ku, 3-1-1 Maidashi, Fukuoka 8128582, Japan.
EM tkishi@cardiol.med.kyushu-u.ac.jp
RI Kishi, Takuya/ITU-1075-2023
FU Japan Society for the Promotion of Science [22790709]; Kimura Memorial
   Foundation
FX This study was supported by a Grant-in-Aid for Scientific Research from
   the Japan Society for the Promotion of Science (22790709 to Kishi) and,
   in part, a Kimura Memorial Foundation Research Grant.
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NR 32
TC 57
Z9 62
U1 0
U2 15
PU INT HEART JOURNAL ASSOC
PI TOKYO
PA UNIV TOKYO, GRADUATE SCHOOL MEDICINE, DEPT CARDIOVASCULAR MEDICINE,
   HONGO 7-3-1, BUNKYO-KU, TOKYO, 113-8655, JAPAN
SN 1349-2365
EI 1349-3299
J9 INT HEART J
JI Int. Heart J.
PD JAN
PY 2015
VL 56
IS 1
BP 110
EP 115
DI 10.1536/ihj.14-168
PG 6
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA CD4BO
UT WOS:000351027800019
PM 25503654
OA Bronze
DA 2025-06-11
ER

PT J
AU Morelli, NR
   Scavuzzi, BM
   Miglioranza, LHD
   Lozovoy, MAB
   Simao, ANC
   Dichi, I
AF Morelli, Nayara Rampazzo
   Scavuzzi, Bruna Miglioranza
   da Silva Miglioranza, Lucia Helena
   Batisti Lozovoy, Marcell Alysson
   Colado Simao, Andrea Name
   Dichi, Isaias
TI Metabolic syndrome components are associated with oxidative stress in
   overweight and obese patients
SO ARCHIVES OF ENDOCRINOLOGY METABOLISM
LA English
DT Article
DE Overweight; obesity; metabolic syndrome; oxidative stress; nitrosative
   stress
ID NITRIC-OXIDE METABOLITES; COMMON SOIL HYPOTHESIS; INSULIN-RESISTANCE;
   PROTEIN PRODUCTS; CARDIOVASCULAR-DISEASE; LIPID-PEROXIDATION; RISK;
   INFLAMMATION; WOMEN; BIOMARKERS
AB Objective: The aim of this study is to evaluate the influence of the body mass index (BMI) and the metabolic syndrome (MetS) parameters on oxidative and nitrosative stress in overweight and obese subjects. Subjects and methods: Individuals were divided into three groups: the control group (G1, n = 131) with a BMI between 20 and 24.9 kg/m(2), the overweight group (G2, n = 120) with a BMI between 25 and 29.9 kg/m(2) and the obese group (G3, n = 79) with a BMI >= 30 kg/m(2). Results: G3 presented higher advanced oxidation protein products (AOPPs) in relation to G1 and G2 (p = 0.001 and p = 0.011, respectively) whereas G2 and G3 had lower levels of nitric oxide (NO) (p = 0.009 and p = 0.048, respectively) compared to G1. Adjusted for the presence of MetS to evaluate its influence, the levels of AOPPs did not differ between the groups, whereas NO remained significantly lower. Data adjusted by the BMI showed that subjects with higher triacylglycerol levels had higher AOPPs (p = 0.001) and decreased total radical-trapping antioxidant parameter/uric Acid (p = 0.036). Subjects with lower high-density lipoprotein (HDL) levels and patients with higher blood pressure showed increased AOPPs (p = 0.001 and p = 0.034, respectively) and lower NO levels (p = 0.017 and p = 0.043, respectively). Subjects who presented insulin resistance had higher AOPPs (p = 0.024). Conclusions: Nitrosative stress was related to BMI, and protein oxidation and nitrosative stress were related to metabolic changes and hypertension. MetS components were essential participants in oxidative and nitrosative stress in overweight and obese subjects. Arch Endocrinol Metab. 2018;62(3):309-18
C1 [Morelli, Nayara Rampazzo; Scavuzzi, Bruna Miglioranza] Univ Estadual Londrina, Dept Posgrad Ciencias Saude, Londrina, PR, Brazil.
   [da Silva Miglioranza, Lucia Helena] Univ Estadual Londrina, Dept Ciencia & Tecnol Alimentos, Londrina, PR, Brazil.
   [Batisti Lozovoy, Marcell Alysson; Colado Simao, Andrea Name] Univ Estadual Londrina, Dept Patol Anal Clin & Toxicol, Londrina, PR, Brazil.
   [Dichi, Isaias] Univ Estadual Londrina, Dept Med Interna, Av Robert Koch 60, BR-86038440 Londrina, PR, Brazil.
C3 Universidade Estadual de Londrina; Universidade Estadual de Londrina;
   Universidade Estadual de Londrina; Universidade Estadual de Londrina
RP Dichi, I (corresponding author), Univ Estadual Londrina, Dept Med Interna, Av Robert Koch 60, BR-86038440 Londrina, PR, Brazil.
EM dichi@sercomtel.com.br
RI Miglioranza, Lucia/H-1656-2012; Scavuzzi, Bruna/AAK-7916-2020; Lozovoy,
   Marcell/AAM-4897-2021; Simão, Andrea/AAM-4892-2021
OI Miglioranza Scavuzzi, Bruna/0000-0001-9609-001X
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NR 39
TC 22
Z9 23
U1 0
U2 2
PU SBEM-SOC BRASIL ENDOCRINOLOGIA & METABOLOGIA
PI RIO DE JANEIRO, RJ
PA RUA HUMAITA, 85 CJ 501, RIO DE JANEIRO, RJ, 22261-000, BRAZIL
SN 2359-3997
EI 2359-4292
J9 ARCH ENDOCRIN METAB
JI Arch. Endocrinol. Metab.
PD MAY-JUN
PY 2018
VL 62
IS 3
BP 309
EP 318
DI 10.20945/2359-3997000000036
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA GL3ZJ
UT WOS:000437084400007
PM 29791650
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Liang, CC
   Shaw, SW
   Hsieh, WC
   Huang, YH
   Liang, CY
   Lee, TH
AF Liang, Ching-Chung
   Shaw, Steven W.
   Hsieh, Wu-Chiao
   Huang, Yung-Hsin
   Liang, Chu-Ya
   Lee, Tsong-Hai
TI Bladder dysfunction in hypoestrogenic rats with metabolic syndrome can
   be ameliorated after amniotic fluid stem cell treatment
SO STEM CELLS TRANSLATIONAL MEDICINE
LA English
DT Article
DE estrogen; menopause; metabolic syndrome; mitochondria; overactive
   bladder; stem cell
ID INDUCED OVERACTIVE BLADDER; OXIDATIVE STRESS; HIGH-FAT; MENOPAUSE;
   WOMEN; EXPRESSION; DECREASE; OBESITY
AB Background Bladder dysfunction may occur with high frequency in postmenopausal women with metabolic syndrome (MetS). This study evaluated the therapeutic effects of human amniotic fluid stem cells (hAFSCs) on bladder dysfunction in ovariectomized rats with MetS.Materials and Methods Forty-eight female rats were divided into 4 groups: normal control, ovariectomy (OVX), and OVX and MetS without (OVX + MetS) and with hAFSCs treatment (OVX + MetS + hAFSCs). We assessed cystometric parameters, serum biochemistry parameters, wall thickness of iliac artery, apoptotic cells and collagen volume in bladder tissues, and the expressions of purinergic and muscarinic receptors, apoptosis-associated mitochondrial proteins, and markers of inflammation, fibrosis, and oxidative stress at posttreatment 1 and 3 months.Results OVX + MetS rats showed significant dysfunction of bladder storage, including reduced intercontraction intervals and bladder capacity, along with increased residual urine volume and nonvoiding contractions. There was a significant increase in iliac artery wall thickness, bladder collagen volume, and number of apoptotic cells. Also, there were elevated expressions of P2X3 purinergic and M2/M3 muscarinic receptors, pro-apoptotic proteins, and markers of inflammation, fibrosis, and oxidative stress, with a concurrent decrease in anti-apoptotic protein, Bcl-2. Treatment with hAFSCs helped restoring bladder function, ameliorating histological abnormalities, and reducing pathological markers at 1 and/or 3 months.Conclusion These findings suggest that hAFSCs can effectively mitigate bladder dysfunction in rats with ovarian hormone deficiency and MetS by modulating oxidative stress and mitochondrial apoptotic pathways.
C1 [Liang, Ching-Chung; Hsieh, Wu-Chiao; Huang, Yung-Hsin] Chang Gung Mem Hosp, Linkou Med Ctr, Dept Obstet & Gynecol, Female Urol Sect, Taoyuan 333, Taiwan.
   [Liang, Ching-Chung; Shaw, Steven W.; Hsieh, Wu-Chiao; Lee, Tsong-Hai] Chang Gung Univ, Coll Med, Taoyuan 333, Taiwan.
   [Shaw, Steven W.] Taipei Chang Gung Mem Hosp, Dept Obstet & Gynecol, Div Obstet, Taipei 105, Taiwan.
   [Shaw, Steven W.] UCL, Inst Womens Hlth, Prenatal Cell & Gene Therapy Grp, London WC1N 1EH, England.
   [Liang, Chu-Ya] Chang Gung Univ, Coll Management, Taoyuan 333, Taiwan.
   [Lee, Tsong-Hai] Chang Gung Mem Hosp, Stroke Ctr, Linkou Med Ctr, 5 Fu Hsing St, Taoyuan 333, Taiwan.
   [Lee, Tsong-Hai] Chang Gung Mem Hosp, Linkou Med Ctr, Dept Neurol, 5 Fu Hsing St, Taoyuan 333, Taiwan.
C3 Chang Gung Memorial Hospital; Chang Gung University; Chang Gung Memorial
   Hospital; University of London; University College London; Chang Gung
   University; Chang Gung Memorial Hospital; Chang Gung Memorial Hospital
RP Lee, TH (corresponding author), Chang Gung Mem Hosp, Stroke Ctr, Linkou Med Ctr, 5 Fu Hsing St, Taoyuan 333, Taiwan.; Lee, TH (corresponding author), Chang Gung Mem Hosp, Linkou Med Ctr, Dept Neurol, 5 Fu Hsing St, Taoyuan 333, Taiwan.
EM thlee@adm.cgmh.org.tw
RI Lee, Tsong-Hai/AAW-4634-2020
FU Ministry of Science and Technology Taiwan [MOST 108-2314-B-182A-083,
   MOST 109-2314-B-182A-091, MOST 111-2314-B-182A-144 -MY3]
FX This research was funded by the Ministry of Science and Technology
   Taiwan grants: MOST 108-2314-B-182A-083 (C.-C.L.), MOST
   109-2314-B-182A-091 (C.-C.L.), and MOST 111-2314-B-182A-144 -MY3
   (T.-H.L.).
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NR 39
TC 0
Z9 0
U1 0
U2 0
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 2157-6564
EI 2157-6580
J9 STEM CELL TRANSL MED
JI Stem Cells Transl. Med.
PD MAR
PY 2025
VL 14
IS 3
AR szae100
DI 10.1093/stcltm/szae100
PG 13
WC Cell & Tissue Engineering
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA 1JT5M
UT WOS:001466683100005
PM 40167277
OA gold
DA 2025-06-11
ER

PT J
AU Gregório, BM
   De Souza, DB
   Nascimento, FAD
   Matta, L
   Fernandes-Santos, C
AF Gregorio, Bianca Martins
   De Souza, Diogo Benchimol
   de Morais Nascimento, Fernanda Amorim
   Matta, Leonardo
   Fernandes-Santos, Caroline
TI The Potential Role of Antioxidants in Metabolic Syndrome
SO CURRENT PHARMACEUTICAL DESIGN
LA English
DT Article
DE Metabolic syndrome; antioxidants; oxidative stress; vitamins;
   carotenoids; arginine; resveratrol; selenium.
ID SERUM CAROTENOID CONCENTRATIONS; IMPROVES ENDOTHELIAL FUNCTION;
   CARDIOVASCULAR RISK-FACTORS; VITAMIN-C; L-ARGININE; OXIDATIVE STRESS;
   BLOOD-PRESSURE; ADIPOSE-TISSUE; BETA-CAROTENE; INSULIN SENSITIVITY
AB Metabolic syndrome (MS) is a constellation of risk factors that raise the risk for heart disease and other health problems, such as obesity. The clustering of metabolic abnormality is closely related to oxidative stress and inflammation, as well as the progression of atherosclerosis. Antioxidants are reducing agents which inhibit the oxidation of other molecules and can be used not only to prevent but also to treat health complications of MS and atherosclerosis. They can be ingested in the normal diet, since they are found in many food sources, or in supplement formulations. Herein, we aim to review the literature concerning the effect of antioxidants on MS. We focus on antioxidants with some evidence of action on this condition, like flavonoids, arginine, vitamin C, vitamin E, carotenoids, resveratrol and selenium. Experimental and clinical studies show that most of the above-mentioned antioxidants exhibit a wide range of effects in protecting the human body, especially in MS patients. However, the underlying mechanisms are not fully elucidated for most of these compounds. Also, some of them should be used with caution because their excess can be toxic to the body. In general, antioxidants (especially those present in foods) can be used by MS individuals because of their direct effect on oxidative stress. Additionally, they should be encouraged as part of a nutritional lifestyle change, since this is part of the therapy for all diseases involved in metabolic disorders.
C1 [Gregorio, Bianca Martins; De Souza, Diogo Benchimol; Matta, Leonardo] Univ Estado Rio De Janeiro, UERJ, BR-20551030 Rio De Janeiro, RJ, Brazil.
   [de Morais Nascimento, Fernanda Amorim] Univ Fed Rio de Janeiro, UFRJ, Macae, Brazil.
   [Fernandes-Santos, Caroline] Univ Fed Fluminense, Nova Friburgo, Brazil.
C3 Universidade do Estado do Rio de Janeiro; Universidade Federal do Rio de
   Janeiro; Universidade Federal Fluminense
RP De Souza, DB (corresponding author), Univ Estado Rio De Janeiro, Urogenital Res Unit, Av 28 Setembro,87 Fundos, BR-20551030 Rio De Janeiro, RJ, Brazil.; Fernandes-Santos, C (corresponding author), Univ Fed Fluminense, Dept Basic Sci, Rua Dr Silvio Henrique Braune 22, Nova Friburgo, RJ, Brazil.
EM diogobenchimol@gmail.com; cf_santos@id.uff.br
RI Matta, Leonardo/HKN-7192-2023; de Souza, Diogo/J-3075-2014; Gregório,
   Bianca/O-4359-2014; Fernandes-Santos, Caroline/M-1794-2019
OI Matta, Leonardo/0000-0002-3892-6330; Fernandes-Santos,
   Caroline/0000-0002-2420-3836
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NR 161
TC 65
Z9 69
U1 1
U2 29
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1381-6128
EI 1873-4286
J9 CURR PHARM DESIGN
JI Curr. Pharm. Design
PY 2016
VL 22
IS 7
BP 859
EP 869
DI 10.2174/1381612822666151209152352
PG 11
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA DG4VQ
UT WOS:000372071600009
PM 26648468
DA 2025-06-11
ER

PT J
AU Patti, AM
   Al-Rasadi, K
   Katsiki, N
   Banerjee, Y
   Nikolic, D
   Vanella, L
   Giglio, RV
   Giannone, VA
   Montalto, G
   Rizzo, M
AF Patti, Angelo Maria
   Al-Rasadi, Khalid
   Katsiki, Niki
   Banerjee, Yajnavalka
   Nikolic, Dragana
   Vanella, Luca
   Giglio, Rosaria Vincenza
   Giannone, Valeria Ausilia
   Montalto, Giuseppe
   Rizzo, Manfredi
TI Effect of a Natural Supplement Containing Curcuma Longa, Guggul,
   and Chlorogenic Acid in Patients With Metabolic Syndrome
SO ANGIOLOGY
LA English
DT Article
DE natural supplement; oxidative stress; metabolic syndrome; cholesterol;
   Curcuma longa; silymarin; guggul; chlorogenic acid; inulin
ID LIPOPROTEIN LDL SUBCLASSES; DOUBLE-BLIND; COMMIPHORA-MUKUL; ENZYMATIC
   DETERMINATION; CLINICAL-SIGNIFICANCE; OXIDATIVE STRESS; EUROPEAN PANEL;
   HIGH-FAT; STATEMENT; EFFICACY
AB The impact of a natural supplement (Kepar; Rikrea, Italy), containing several plant extracts such as curcuma longa, silymarin, guggul, chlorogenic acid, and inulin, was evaluated in 78 patients with metabolic syndrome (MetS; 45 men; age: 62 +/- 9 years). Kepar at a dose of 2 pills/d was given for 4 months as add-on therapy to the ongoing treatment, maintained at fixed doses for the entire study. Anthropometric variables, plasma lipids, glucose parameters, and oxidative stress were measured at baseline and after 4 months. We found significant reductions in body weight (from 81.1 +/- 13.5 to 79.4 +/- 12.5 kg, P < .0001), body mass index (from 29.6 [23.7] to 29.3 [21.9] kg/m(2), P = .001), and waist circumference (from 105 +/- 11 to 102 +/- 10 cm, P = .0004) as well as in fasting glucose (from 6.5 [11.7] to 6.4 [7.6] mmol/L, P = .014) and total cholesterol (from 4.8 +/- 1.4 to 4.5 +/- 1.0 mmol/L, P = .03). No significant changes were found in the other appraised parameters, including oxidative stress. In conclusion, after few months of treatment Kepar seems to exert beneficial effects in patients with MetS. Larger studies with a longer follow-up period are needed to confirm these preliminary findings.
C1 [Patti, Angelo Maria; Nikolic, Dragana; Giglio, Rosaria Vincenza; Giannone, Valeria Ausilia; Montalto, Giuseppe; Rizzo, Manfredi] Univ Palermo, Biomed Dept Internal Med & Med Specialties, I-90127 Palermo, Italy.
   [Al-Rasadi, Khalid] Sultan Qaboos Univ Hosp, Dept Clin Biochem, Muscat, Oman.
   [Katsiki, Niki] Aristotle Univ Thessaloniki, Hippokrat Hosp, Sch Med, Propedeut Dept Internal Med 2, GR-54006 Thessaloniki, Greece.
   [Banerjee, Yajnavalka] Sultan Qaboos Univ, Coll Med & Hlth Sci, Dept Biochem, Muscat, Oman.
   [Vanella, Luca] Univ Catania, Dept Drug Sci, Catania, Italy.
C3 University of Palermo; Sultan Qaboos University; Aristotle University of
   Thessaloniki; Sultan Qaboos University; University of Catania
RP Rizzo, M (corresponding author), Univ Palermo, Biomed Dept Internal Med & Med Specialties, Via Vespro 141, I-90127 Palermo, Italy.
EM manfredi.rizzo@unipa.it
RI GIGLIO, Rosaria Vincenza/IAR-9444-2023; Al-Rasadi, Khalid/ABB-7852-2020;
   RIZZO, MANFREDI/GZL-0551-2022; Banerjee, Yajnavalka/J-5890-2019;
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   Khalid/J-7194-2015
OI RIZZO, Manfredi/0000-0002-9549-8504; KATSIKI, NIKI/0000-0003-0894-2644;
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   Banerjee, Yajnavalka/0000-0002-7546-8893; Al-Rasadi,
   Khalid/0000-0003-0460-1236; Nikolic, Dragana/0000-0001-9572-9651
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NR 48
TC 34
Z9 35
U1 1
U2 12
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0003-3197
EI 1940-1574
J9 ANGIOLOGY
JI Angiology
PD OCT
PY 2015
VL 66
IS 9
BP 856
EP 861
DI 10.1177/0003319714568792
PG 6
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA CR0LY
UT WOS:000361011400010
PM 25632052
DA 2025-06-11
ER

PT J
AU Kim, H
   Simbo, SY
   Fang, C
   McAlister, L
   Roque, A
   Banerjee, N
   Talcott, ST
   Zhao, HW
   Kreider, RB
   Mertens-Talcott, SU
AF Kim, Hyemee
   Simbo, Sunday Y.
   Fang, Chuo
   McAlister, Lilly
   Roque, Andrea
   Banerjee, Nivedita
   Talcott, Stephen T.
   Zhao, Hongwei
   Kreider, Richard B.
   Mertens-Talcott, Susanne U.
TI Acai (Euterpe oleracea Mart.) beverage consumption improves
   biomarkers for inflammation but not glucose- or lipid-metabolism in
   individuals with metabolic syndrome in a randomized, double-blinded,
   placebo-controlled clinical trial
SO FOOD & FUNCTION
LA English
DT Article
ID ENDOTHELIAL-CELLS HUVEC; HIGH-FAT DIET; INSULIN-RESISTANCE; IN-VITRO;
   ANTHOCYANINS; MARKERS; ASSOCIATION; POLYPHENOLS; POPULATION; HEALTH
AB Acai (Euterpe oleracea Mart.) berries, characterized by high polyphenol concentrations (predominantly anthocyanins), have demonstrated anti-inflammatory and anti-diabetic activities. The study objective was to determine the modulation of lipid and glucose-metabolism, as well as oxidative stress and inflammation, by an acai-beverage (containing 1139 mg L-1 gallic acid equivalents of total polyphenolics) in 37 individuals with metabolic syndrome (BMI 33.5 +/- 6.7 kg m(-2)) who were randomized to consume 325 mL twice per d of a placebo control or acai-beverage for 12 weeks. Anthropometric measurements, dietary intake, and blood and urine samples were collected at baseline and after 12 weeks of consumption. Two functional biomarkers, plasma level of interferon gamma (IFN-gamma) and urinary level of 8-isoprostane, were significantly decreased after 12 weeks of acai consumption compared to the placebo control (p = 0.0141 and 0.0099, respectively). No significant modification of biomarkers for lipid- and glucose-metabolism was observed in this study. Findings from this small pilot study provide a weak indication that the selected dose of acai polyphenols may be beneficial in metabolic syndrome as only two biomarkers for inflammation and oxidative stress were improved over 12 weeks. Follow-up studies should be conducted with higher polyphenol-doses before drawing conclusions regarding the efficacy of acai polyphenols in metabolic syndrome.
C1 [Kim, Hyemee; Fang, Chuo; McAlister, Lilly; Roque, Andrea; Talcott, Stephen T.; Mertens-Talcott, Susanne U.] Texas A&M Univ, Dept Nutr & Food Sci, College Stn, TX 77843 USA.
   [Simbo, Sunday Y.; Kreider, Richard B.] Texas A&M Univ, Dept Hlth & Kinesiol, College Stn, TX 77843 USA.
   [Banerjee, Nivedita] Texas A&M Univ, Interdisciplinary Program Toxicol, College Stn, TX 77843 USA.
   [Zhao, Hongwei] Texas A&M Univ, Dept Epidemiol & Biostat, College Stn, TX 77843 USA.
C3 Texas A&M University System; Texas A&M University College Station; Texas
   A&M University System; Texas A&M University College Station; Texas A&M
   University System; Texas A&M University College Station; Texas A&M
   University System; Texas A&M University College Station
RP Mertens-Talcott, SU (corresponding author), Texas A&M Univ, Dept Nutr & Food Sci, College Stn, TX 77843 USA.
EM smtalcott@tamu.edu
RI Kreider, Richard/AEE-5745-2022; Kreider, Richard/O-1804-2014
OI Kim, Hyemee/0000-0002-0713-3952; Mertens-Talcott,
   Susanne/0000-0003-2828-4044; Kreider, Richard/0000-0002-3906-1658
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TC 54
Z9 55
U1 1
U2 29
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PD JUN 1
PY 2018
VL 9
IS 6
BP 3097
EP 3103
DI 10.1039/c8fo00595h
PG 7
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA GK3GD
UT WOS:000436029300004
PM 29850709
DA 2025-06-11
ER

PT J
AU Lee, H
   Jose, PA
AF Lee, Hewang
   Jose, Pedro A.
TI Coordinated Contribution of NADPH Oxidase- and Mitochondria-Derived
   Reactive Oxygen Species in Metabolic Syndrome and Its Implication in
   Renal Dysfunction
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Review
DE metabolic syndrome; mitochondria; nicotinamide-adenine dinucleotide
   phosphate oxidase; NLRP3; oxidative stress; reactive oxygen species;
   pyruvate dehydrogenase complex; renal dysfunction
ID PYRUVATE-DEHYDROGENASE COMPLEX; RECEPTOR-INDUCED INHIBITION; VASCULAR
   OXIDATIVE STRESS; LOWERS BLOOD-PRESSURE; INDUCED ROS RELEASE;
   HYDROGEN-PEROXIDE; NLRP3 INFLAMMASOME; CROSS-TALK;
   SUPEROXIDE-PRODUCTION; MOLECULAR-MECHANISMS
AB Metabolic syndrome (MetS), a complex of interrelated risk factors for cardiovascular disease and diabetes, is comprised of central obesity (increased waist circumference), hyperglycemia, dyslipidemia (high triglyceride blood levels, low high-density lipoprotein blood levels), and increased blood pressure. Oxidative stress, caused by the imbalance between pro-oxidant and endogenous antioxidant systems, is the primary pathological basis of MetS. The major sources of reactive oxygen species (ROS) associated with MetS are nicotinamide-adenine dinucleotide phosphate (NADPH) oxidases and mitochondria. In this review, we summarize the current knowledge regarding the generation of ROS from NADPH oxidases and mitochondria, discuss the NADPH oxidase- and mitochondria-derived ROS signaling and pathophysiological effects, and the interplay between these two major sources of ROS, which leads to chronic inflammation, adipocyte proliferation, insulin resistance, and other metabolic abnormalities. The mechanisms linking MetS and chronic kidney disease are not well known. The role of NADPH oxidases and mitochondria in renal injury in the setting of MetS, particularly the influence of the pyruvate dehydrogenase complex in oxidative stress, inflammation, and subsequent renal injury, is highlighted. Understanding the molecular mechanism(s) underlying MetS may lead to novel therapeutic approaches by targeting the pyruvate dehydrogenase complex in MetS and prevent its sequelae of chronic cardiovascular and renal diseases.
C1 [Lee, Hewang; Jose, Pedro A.] George Washington Univ, Dept Med, Sch Med & Hlth Sci, Washington, DC 20052 USA.
   [Jose, Pedro A.] George Washington Univ, Dept Pharmacol & Physiol, Sch Med & Hlth Sci, Washington, DC 20052 USA.
C3 George Washington University; George Washington University
RP Jose, PA (corresponding author), George Washington Univ, Dept Med, Sch Med & Hlth Sci, Washington, DC 20052 USA.; Jose, PA (corresponding author), George Washington Univ, Dept Pharmacol & Physiol, Sch Med & Hlth Sci, Washington, DC 20052 USA.
EM pjose@mfa.gwu.edu
RI Jose, Pedro/GZL-8630-2022; Lee, Hewang/KHU-0412-2024
OI Lee, Hewang/0000-0003-1338-2573
FU US National Institutes of Health [R01DK119652, R37HL023081, R01DK039308,
   R01HL092196, R01DK090918, P01HL068686, P01HL074940, U01GM074492]
FX The work was funded by grants from the US National Institutes of Health
   R01DK119652, R37HL023081, R01DK039308, R01HL092196, R01DK090918,
   P01HL068686, P01HL074940 and U01GM074492.
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NR 202
TC 30
Z9 32
U1 0
U2 13
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD MAY 4
PY 2021
VL 12
AR 670076
DI 10.3389/fphar.2021.670076
PG 18
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA SD5DR
UT WOS:000651393500001
PM 34017260
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Adams-Huet, B
   Jialal, I
AF Adams-Huet, Beverley
   Jialal, Ishwarlal
TI Correlates of Insulin Resistance in Nascent Metabolic Syndrome
SO CLINICAL MEDICINE INSIGHTS-ENDOCRINOLOGY AND DIABETES
LA English
DT Article
DE Metabolic syndrome; insulin resistance; inflammation; oxidative stress;
   fatty acids
ID HORMONE-BINDING GLOBULIN; ADIPOSE-TISSUE; HOMA-IR; DIAGNOSIS; CHEMERIN;
   PLASMA
AB Background:Metabolic Syndrome (MetS), a major global problem, is a cluster of cardio-metabolic risk factors that predisposes to both type 2 diabetes mellitus (T2DM) and premature atherosclerotic cardiovascular disease (ASCVD). Insulin resistance is a major underpinning of MetS. Objectives:We investigated the relationship between insulin resistance and biomarkers of inflammation, oxidative stress, free fatty acids (FFA) levels and adipokine dysregulation in a cohort of nascent MetS. Design:This was a cross-sectional study comparing patients with MetS with matched controls. Patients and Methods:Participants included 47 patients with MetS and 41 controls. Persons with diabetes, ASCVD, smoking and macro-inflammation were excluded. Fasting blood was obtained for both plasma and monocyte isolation. Homeostasis model assessment insulin resistance index (HOMA-IR) was calculated from fasting glucose and insulin levels. Results:The patients were insulin resistant as determined by a valid measure, HOMA-IR. HOMA-IR increased with increasing severity of MetS and correlated with cardio-metabolic features, hsCRP, FFA levels, and adipose tissue insulin resistance. Insulin resistance also correlated with biomarkers of oxidative stress and both circulating and cellular biomarkers of inflammation. Receiver operating Characteristic (ROC) curve analysis revealed that HOMA-IR was an excellent predictor of MetS with an area under the curve of 0.80. Conclusion:In our patients with nascent MetS we show that they have significant insulin resistance. Based on our findings, elevated FFA levels, oxidative stress and inflammation could contribute to the insulin resistance.
C1 [Adams-Huet, Beverley] UT Southwestern Med Ctr Dallas, Dallas, TX USA.
   [Jialal, Ishwarlal] Veterans Affairs Med Ctr, Mather, CA USA.
   [Jialal, Ishwarlal] Univ Calif Davis, VA Med Ctr, 10535 Hosp Way, Mather, CA 95655 USA.
C3 University of California System; University of California Davis
RP Jialal, I (corresponding author), Univ Calif Davis, VA Med Ctr, 10535 Hosp Way, Mather, CA 95655 USA.
EM kjialal@gmail.com
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NR 33
TC 1
Z9 1
U1 1
U2 5
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1179-5514
J9 CLIN MED INSIGHTS-EN
JI Clin. Med. Insights-Endocrinol. Diabetes
PY 2023
VL 16
AR 11795514231168279
DI 10.1177/11795514231168279
PG 5
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA D8VA3
UT WOS:000971438600001
PM 37113327
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Stefanaki, K
   Karagiannakis, DS
   Raftopoulou, M
   Psaltopoulou, T
   Paschou, SA
   Ilias, I
AF Stefanaki, Katerina
   Karagiannakis, Dimitrios S. S.
   Raftopoulou, Marina
   Psaltopoulou, Theodora
   Paschou, Stavroula A. A.
   Ilias, Ioannis
TI Obesity and hyperandrogenism are implicated with anxiety, depression and
   food cravings in women with polycystic ovary syndrome
SO ENDOCRINE
LA English
DT Article
DE Polycystic Ovary Syndrome; Obesity; Eating disorders; Depression;
   Anxiety; Food cravings
ID EATING ATTITUDES TEST; PREVALENCE; MANAGEMENT; RESISTANCE; DISORDERS;
   SYMPTOMS; APPETITE; EAT-26; RISK
AB IntroductionPCOS is associated with mood/eating disorders. Negative body image due to obesity, acne, hirsutism seems to play significant role, but hormonal derangements are probably implicated.AimTo investigate the relation between insulin resistance (IR), obesity and hyperandrogenism with mood and eating disorders in women with PCOS.MethodsForty-nine (60.5%) PCOS women and 32(39.5%) age- and BMI-matched healthy controls were enrolled. Emotional/food disorders were evaluated by using self-administered questionnaires: Eating Attitudes Test (EAT)-26, Beck Depression Inventory-II (BDI-II), Hamilton anxiety scale (HAS) and Food Craving Questionnaire-Trait (FCQ-T).ResultsThe two groups had no significant differences regarding age, BMI and HOMA2-IR. PCOS women had significantly higher DHEA-S (p < 0.0001), & UDelta;4 & UAlpha; (p < 0.0001) and Testosterone (p < 0.0001). When the two groups were subclassified according to the BMI, in lean (BMI < 25 kg/m(2)) or overweight (BMI & GE; 25 kg/m(2)), no significant differences were found with respect to EAT-26 and HAS. BDI-II was associated with obesity (overweight vs lean PCOS: 20.5 & PLUSMN; 6.4 vs 9.8 & PLUSMN; 3.9; p = 0.037) and hyperandrogenism (overweight PCOS vs overweight controls: 20.5 & PLUSMN; 6.4 vs 14.8 & PLUSMN; 8.1; p < 0.0001; lean PCOS vs overweight controls: 16.7 & PLUSMN; 4.7 vs 14.8 & PLUSMN; 8.1; p = 0.01). Additionally, a significant correlation between BDI-II and DHEA-S (rho = 0.305; p = 0.006), & UDelta;4 & UAlpha; (rho = 0.259; p = 0.02) and Testosterone (rho = 0.328; p = 0.003) was reported. FCQ-T was associated with obesity (overweight PCOS vs lean PCOS: 47.6 & PLUSMN; 9.9 vs 29.3 & PLUSMN; 8.9; p < 0.0001; overweight controls vs lean PCOS: 45.5 & PLUSMN; 15.7 vs 29.3 & PLUSMN; 8.9; p < 0.0001), whereas a correlation between FCQ-T and BMI (rho = 0.593; p = 0.0001), waist circumference (rho = 0.554; p = 0.0001) and HOMA2-IR (rho = 0.328; p = 0.003) was documented.ConclusionsObesity and hyperandrogenism increase the risk of depression and food cravings in women with PCOS, leading to a vicious circle of further aggravation of obesity and metabolic syndrome.
C1 [Stefanaki, Katerina; Psaltopoulou, Theodora; Paschou, Stavroula A. A.] Natl & Kapodistrian Univ Athens, Alexandra Gen Hosp, Sch Med, Dept Clin Therapeut, Athens, Greece.
   [Karagiannakis, Dimitrios S. S.] Natl & Kapodistrian Univ Athens, Laiko Gen Hosp, Sch Med, Acad Dept Gastroenterol, Athens, Greece.
   [Raftopoulou, Marina] Athens Med Ctr, Diabet Unit, Athens, Greece.
   [Ilias, Ioannis] Elena Venizelou Gen Hosp, Dept Endocrinol Diabet & Metab, Athens, Greece.
C3 Athens Medical School; National & Kapodistrian University of Athens;
   Alexandra Hospital; National & Kapodistrian University of Athens; Laiko
   General Hospital; Athens Medical School
RP Karagiannakis, DS (corresponding author), Natl & Kapodistrian Univ Athens, Laiko Gen Hosp, Sch Med, Acad Dept Gastroenterol, Athens, Greece.
EM dkarag@med.uoa.gr
RI Ilias, Ioannis/AAA-2927-2020; S Karagiannakis, Dimitrios/AFQ-7294-2022
OI S Karagiannakis, Dimitrios/0000-0003-0082-634X
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NR 41
TC 11
Z9 11
U1 3
U2 12
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1355-008X
EI 1559-0100
J9 ENDOCRINE
JI Endocrine
PD OCT
PY 2023
VL 82
IS 1
BP 201
EP 208
DI 10.1007/s12020-023-03436-1
EA JUN 2023
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA Y6HJ8
UT WOS:001020144900001
PM 37389719
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Mbappe, FE
   Ebouel, FLE
   Ella, FA
   Akamba, BDA
   Nanhah, JK
   Gouado, I
   Ngondi, JL
AF Mbappe, Florine Essouman
   Ebouel, Ferdinand Lanvin Edoun
   Ella, Fils Armand
   Akamba, Bruno Dupon Ambamba
   Nanhah, Jules Kamga
   Gouado, Innocent
   Ngondi, Judith Laure
TI Effect of Beilschmedia obscura on the prevention of high fat/high
   sucrose diet induced metabolic syndrome on male Albino Wistar rats
SO METABOLISM OPEN
LA English
DT Article
DE Beilschmiedia obscura; Metabolic syndrome; High fat/high sucrose diet
ID EXTRACT; ASSAY
AB Introduction: Beilschmiedia (Lauraceae) is a pantropical genus of about 287 species, distributed in tropical Asia and Africa used in traditional medicines to cure many diseases. This study aimed to explore biological properties of Beilschmiedia obscura (B. obscura) on the prevention and management of metabolic syndrome (MetS) features induced by High Fat/High Sucrose (HF/HS) diet in rats as therapeutic option. Methods: MetS was induced after administration of HF/HS diet followed by administration of B. Obscura powder at 5% or 10% for 21 days, while the control group received a chow diet and distilled water and the positive control group received the HF/HS diet and distilled water. At the end of the experiment, rats were sacrificed; the parameters of lipid profile, markers of oxidative stress, antioxidant status were evaluated. Results: HF/HS diet successfully induced weight gain, oxidative stress and lipid profile disorders from rats. Treatment with powder of B. obscura at 10% than the 5% showed a reduction of body weight in treated groups and, anti-hyperlipidemic effect by improving lipid profile parameters. Triglycerides, Total cholesterol and LDL cholesterol levels were lower (p<0.05) and HDL-cholesterol levels higher in the treated groups compared to positive control. Inhibition of lipid peroxidation, and improvement protein thiols levels and catalase activity were also observed in treated groups. Conclusion: This study revealed that B. obscura whole plant was efficient in reducing biomarkers involved in metabolic syndrome and could efficiently help in its management by preventive effect.
C1 [Mbappe, Florine Essouman; Ebouel, Ferdinand Lanvin Edoun; Ella, Fils Armand; Akamba, Bruno Dupon Ambamba; Nanhah, Jules Kamga; Ngondi, Judith Laure] Univ Yaounde I, Fac Sci, Dept Biochem, Yaounde, Cameroon.
   [Ebouel, Ferdinand Lanvin Edoun] Minist Sci Res & Innovat, Ctr Food & Nutr Res, IMPM, Yaounde, Cameroon.
   [Gouado, Innocent] Univ Douala, Fac Sci, Dept Biochem, Douala, Cameroon.
   [Ngondi, Judith Laure] Univ Yaounde I, Fac Sci, Dept Biochem, POB 812, Yaounde, Cameroon.
C3 University of Yaounde I; University of Yaounde I
RP Ngondi, JL (corresponding author), Univ Yaounde I, Fac Sci, Dept Biochem, POB 812, Yaounde, Cameroon.
EM ngondijudithl@hotmail.com
OI EDOUN EBOUEL, Ferdinand Lanvin/0000-0002-9211-7622; AMBAMBA AKAMBA,
   Bruno Dupon/0009-0004-3747-6624
FU FENJ Foundation; University of Yaounde 1
FX This study was partially funded by the FENJ Foundation and the
   University of Yaounde 1.
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NR 31
TC 0
Z9 0
U1 0
U2 3
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
EI 2589-9368
J9 METAB OPEN
JI Metab. Open
PD MAR
PY 2022
VL 13
AR 100156
DI 10.1016/j.metop.2021.100156
PG 5
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA JF8G1
UT WOS:001171837900018
PM 34984333
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Helm, MM
   Alaba, T
   Klimis-Zacas, D
   Izuora, K
   Basu, A
AF Helm, Macy M.
   Alaba, Tolu
   Klimis-Zacas, Dorothy
   Izuora, Kenneth
   Basu, Arpita
TI Effect of Dietary Berry Supplementation on Antioxidant Biomarkers in
   Adults with Cardiometabolic Risks: A Systematic Review of Clinical
   Trials
SO ANTIOXIDANTS
LA English
DT Review
DE oxidative stress; cardiovascular; metabolic syndrome; overweight;
   obesity; strawberries; blueberries; cranberries
ID IMPROVE INSULIN SENSITIVITY; DAILY BLUEBERRY CONSUMPTION; HIGH-FAT MEAL;
   OXIDATIVE STRESS; BLOOD-PRESSURE; CRANBERRY JUICE; DOUBLE-BLIND;
   METABOLIC SYNDROME; OXIDIZED LDL; INFLAMMATORY MARKERS
AB Cardiometabolic conditions are closely associated with inflammation and oxidative stress. Dietary berries may serve as a beneficial nutrition intervention to address the features of cardiometabolic dysfunction and associated oxidative stress. The high antioxidant status of dietary berries may increase antioxidant capacity and reduce biomarkers of oxidative stress. This systematic review was conducted to investigate these effects of dietary berries. The search was conducted using PubMed, Cochrane Library, Web of Science, and citation searching. Through this search we identified 6309 articles and 54 were included in the review. Each study's risk of bias was assessed using the 2019 Cochrane Methods' Risk of Bias 2 tool. Antioxidant and oxidative stress outcomes were evaluated, and the magnitude of effect was calculated using Cohen's d. A range of effectiveness was reported in the included studies and the quality of the studies differed between the parallel and crossover trials. Considering the inconsistency in reported effectiveness, future investigations are warranted to determine the acute and sustained reductions of oxidative stress biomarkers from dietary berry intake (PROSPERO registration# CRD42022374654).
C1 [Helm, Macy M.; Basu, Arpita] Univ Nevada, Sch Integrated Hlth Sci, Dept Kinesiol & Nutr Sci, Las Vegas, NV 89154 USA.
   [Alaba, Tolu; Klimis-Zacas, Dorothy] Univ Maine, Sch Food & Agr, Orono, ME 04469 USA.
   [Alaba, Tolu; Klimis-Zacas, Dorothy] Univ Maine, Grad Sch Biomed Sci & Engn, Orono, ME 04469 USA.
   [Izuora, Kenneth] Univ Nevada, Dept Internal Med, Sect Endocrinol, Las Vegas, NV 89102 USA.
C3 Nevada System of Higher Education (NSHE); University of Nevada Las
   Vegas; University of Maine System; University of Maine Orono; University
   of Maine System; University of Maine Orono; Nevada System of Higher
   Education (NSHE); University of Nevada Las Vegas
RP Basu, A (corresponding author), Univ Nevada, Sch Integrated Hlth Sci, Dept Kinesiol & Nutr Sci, Las Vegas, NV 89154 USA.
EM helmm1@unlv.nevada.edu; tolu.adekeye@maine.edu; dorothea@maine.edu;
   kenneth.izuora@unlv.edu; arpita.basu@unlv.edu
OI Alaba (nee Adekeye), Tolu Esther/0000-0002-1912-0825; Izuora,
   Kenneth/0000-0001-7171-3073
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NR 99
TC 2
Z9 2
U1 1
U2 4
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD JUN
PY 2023
VL 12
IS 6
AR 1182
DI 10.3390/antiox12061182
PG 27
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA K1AR7
UT WOS:001013845900001
PM 37371912
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Theal, R
   Tay, VXP
   Hickman, IJ
AF Theal, Rebecca
   Tay, Valerie Xin Pei
   Hickman, Ingrid J.
TI Conflicting relationship between dietary intake and metabolic health in
   PTSD: A systematic review
SO NUTRITION RESEARCH
LA English
DT Review
DE Dietary intake; Diet quality; Cardiometabolic disease; Posttraumatic
   stress disorder; Systematic review
ID POSTTRAUMATIC-STRESS-DISORDER; PHYSICAL-ACTIVITY;
   CARDIOVASCULAR-DISEASE; GENDER-DIFFERENCES; EATING BEHAVIORS; FOOD
   ADDICTION; FATTY-ACIDS; RISK; METAANALYSIS; SYMPTOMS
AB Posttraumatic stress disorder (PTSD) is a disabling psychological condition associated with significant physical comorbidities. There has been growing evidence to support the relationship between PTSD and cardiometabolic disease. Disordered eating behaviors often seen in people with PTSD symptoms may explain increased cardiometabolic risk. This systematic review aimed to assess the quality of evidence surrounding dietary intake of individuals with symptoms or a diagnosis of PTSD and their associated risk with cardiometabolic health outcomes. Online databases Scopus, ProQuest (Health), Embase, Medline, PsycINFO, and CINAHL with Full Text were searched for peer-reviewed English articles prior to December 2017 that examined dietary intake and cardiometabolic health outcomes in adults with PTSD symptoms or diagnosis. The quality of each study was graded based on the design and methodology using adapted quality assessment tools. Seven studies with five unique participant samples were included in the review. Study methods, design, populations, and outcomes were inconsistent across studies. Dietary intake was considerably varied and limited associations were demonstrated between dietary intake and cardiometabolic risk factors in the PTSD cohorts. Due to the variability of measures and study outcomes, there was insufficient evidence to determine the relationship between dietary intake and PTSD-related cardiometabolic health outcomes. Future studies are needed to examine these associations in individuals with PTSD: specifically higher quality descriptive studies are necessary to confirm a link between diet and cardiometabolic disease in PTSD. (C) 2018 Elsevier Inc. All rights reserved.
C1 [Theal, Rebecca] Greenslopes Private Hosp, Gallipoli Med Res Inst, Newdegate St, Greenslopes, Qld 4120, Australia.
   [Tay, Valerie Xin Pei] Queensland Univ Technol, 2 George St, Brisbane, Qld 4000, Australia.
   [Hickman, Ingrid J.] Princess Alexandra Hosp, Dept Nutr & Dietet, 199 Ipswich Rd, Woolloongabba, Qld 4102, Australia.
   [Hickman, Ingrid J.] Univ Queensland, Mater Res Inst, Aubigny Pl,Raymond Terrance, South Brisbane, Qld 4101, Australia.
C3 Greenslopes Private Hospital; Queensland University of Technology (QUT);
   Princess Alexandra Hospital; University of Queensland; Mater Research
RP Hickman, IJ (corresponding author), Princess Alexandra Hosp, Dept Nutr & Dietet, 199 Ipswich Rd, Woolloongabba, Qld 4102, Australia.
EM ThealR@ramsayhealth.com.au; valeriexinpei.tay@connect.qut.edu.au;
   i.hickman@uq.edu.au
RI ; Hickman, Ingrid J/P-8364-2016
OI Theal, Rebecca/0000-0003-2032-2739; Hickman, Ingrid
   J/0000-0003-3205-9165
FU Returned and Services League, Queensland Branch
FX Salary funding for RT was provided by Returned and Services League,
   Queensland Branch. The authors wish to thank Chloe Kidd and John Gilmour
   for their editorial assistance. The authors report no conflict of
   interest.
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NR 55
TC 9
Z9 10
U1 1
U2 11
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0271-5317
EI 1879-0739
J9 NUTR RES
JI Nutr. Res.
PD JUN
PY 2018
VL 54
BP 12
EP 22
DI 10.1016/j.nutres.2018.03.002
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nutrition & Dietetics
GA GL7PD
UT WOS:000437392900002
PM 29914663
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Krzystek-Korpacka, M
   Patryn, E
   Hotowy, K
   Czapinska, E
   Majda, J
   Kustrzeba-Wojcicka, I
   Noczynska, A
   Gamian, A
AF Krzystek-Korpacka, Malgorzata
   Patryn, Eliza
   Hotowy, Katarzyna
   Czapinska, Elzbieta
   Majda, Jacek
   Kustrzeba-Wojcicka, Irena
   Noczynska, Anna
   Gamian, Andrzej
TI Paraoxonase-1 Activity in Overweight and Obese Children and Adolescents:
   Association with Obesity-Related Inflammation and Oxidative Stress
SO ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE
LA English
DT Article
DE paraoxonase-1 (PON1); obesity; metabolic syndrome; children;
   inflammation; oxidative stress
ID SERUM URIC-ACID; METABOLIC SYNDROME; JUVENILE OBESITY; PROTEIN;
   ADIPONECTIN; SENSITIVITY; HEALTHY; DISEASE; LEPTIN; PLASMA
AB Background. Paraoxonase-1 (PON1) is a HDL-attached extracellular esterase which is believed to contribute to the anti-atherogenic and anti-inflammatory properties of HDL. A decrease in PON1 is a risk factor for cardiovascular disease and has recently been found to be associated with juvenile obesity. The issue of a possible association between enzyme activity and/or its phenotype distribution and obesity-related metabolic abnormalities, inflammation, and oxidative stress has not been addressed yet.
   Objectives. To evaluate PON1 activity and phenotype distribution with respect to obesity and obesity-related metabolic disorders, inflammation and oxidative stress in children and adolescents.
   Material and Methods. PON1 arylesterase activity was measured spectrophotometrically in 156 children and adolescents (47 lean, 27 overweight and 82 obese). Enzyme phenotype was determined using dual substrate (phenyl acetate/paraoxon) method. PON1 activity and phenotype distribution were related to the presence of obesity, metabolic syndrome, insulin resistance, hyperinsulinemia, hypertriglyceridemia, high blood pressure, low HDL level, impaired fasting glucose and/or glucose tolerance as well as inflammatory and oxidative stress indices.
   Results. PON1 arylesterase activity decreased in general and central obesity, high blood pressure, and hyperinsulinemia conditions and correlated with BMI, CRP, adipocyte fatty acid-binding protein, superoxide dismutase, catalase, glutathione peroxidase, free thiols, and HOMA in a gender-dependent manner. PON1 decreases were independently associated with central obesity in girls, explaining 17% in PON1 variability, and with elevated CRP in boys, explaining 12% in its variability. PON1 phenotype was not associated with frequency of metabolic abnormalities.
   Conclusions. PON1 decreases in central obesity, exacerbating obesity-related inflammation and oxidative stress. The enzyme associations are gender-dependent: obesity and oxidative stress affects PON1 in girls whereas inflammation in boys
C1 [Krzystek-Korpacka, Malgorzata; Hotowy, Katarzyna; Czapinska, Elzbieta; Kustrzeba-Wojcicka, Irena; Gamian, Andrzej] Wroclaw Med Univ, Dept Med Biochem, PL-50368 Wroclaw, Poland.
   [Patryn, Eliza; Noczynska, Anna] Wroclaw Med Univ, Dept Endocrinol & Diabetol Children & Adolescents, PL-50368 Wroclaw, Poland.
   [Patryn, Eliza] AMC Amsterdam, Dept Ophthalmol, Amsterdam, Netherlands.
   [Majda, Jacek] 4 Mil Clin Hosp, Dept Lab Diagnost, Wroclaw, Poland.
   [Gamian, Andrzej] Polish Acad Sci, Inst Immunol & Expt Therapy, PL-53114 Wroclaw, Poland.
C3 Wroclaw Medical University; Wroclaw Medical University; University of
   Amsterdam; Academic Medical Center Amsterdam; Polish Academy of
   Sciences; Hirszfeld Institute of Immunology & Experimental Therapy of
   the Polish Academy of Sciences
RP Krzystek-Korpacka, M (corresponding author), Wroclaw Med Univ, Dept Med Biochem, Chalubinskiego 10, PL-50368 Wroclaw, Poland.
EM malgorzata.krzystek-korpacka@umed.wroc.pl
RI Krzystek-Korpacka, Małgorzata/ABA-4556-2021; Wiśniewski,
   Jerzy/HKO-2228-2023
OI Kustrzeba- Wojcicka, Irena/0000-0001-5551-4445; Gamian,
   Andrzej/0000-0002-2206-6591
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NR 28
TC 40
Z9 43
U1 0
U2 8
PU WROCLAW MEDICAL UNIV
PI WROCLAW
PA UL K MARCINKOWSKIEGO 2-6, WROCLAW, 50-368, POLAND
SN 1899-5276
EI 2451-2680
J9 ADV CLIN EXP MED
JI Adv. Clin. Exp. Med.
PD MAR-APR
PY 2013
VL 22
IS 2
BP 229
EP 236
PG 8
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 188QJ
UT WOS:000322208300011
PM 23709379
DA 2025-06-11
ER

PT J
AU Kornicka, K
   Smieszek, A
   Szlapka-Kosarzewska, J
   Houston, JM
   Roecken, M
   Marycz, K
AF Kornicka, Katarzyna
   Smieszek, Agnieszka
   Szlapka-Kosarzewska, Jolanta
   Irwin Houston, Jennifer M.
   Roecken, Michael
   Marycz, Krzysztof
TI Characterization of Apoptosis, Autophagy and Oxidative Stress in
   Pancreatic Islets Cells and Intestinal Epithelial Cells Isolated from
   Equine Metabolic Syndrome (EMS) Horses
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE equine metabolic syndrome; horses; intestinal cells; pancreatic islets;
   autophagy
ID ENDOPLASMIC-RETICULUM STRESS; BETA-CELL; INSULIN-RESISTANCE; EXPRESSION;
   HYPERGLYCEMIA; ANTIOXIDANT; MECHANISMS; DYSFUNCTION; CONTRIBUTE;
   TOXICITY
AB Endocrine disorders are becoming an increasing problem in both human and veterinary medicine. In recent years, more and more horses worldwide have been suffering from equine metabolic syndrome (EMS). This metabolic disorder is characterized by pathological obesity, hyperinsulinaemia, hyperglycaemia and insulin resistance. Although metabolic disorders, including diabetes, have been extensively studied, there are still no data on the molecular effects of EMS in horses. Thus, the aim of this study was to evaluate apoptosis, oxidative stress, autophagy and microRNA (miR) expression in multipotent intestinal epithelial stem cells (IECs) and pancreatic islets (PIs) isolated post mortem form healthy and EMS diagnosed horses. Our group was the first to describe how EMS affects IEC and PI aging and senescence. First, we evaluated isolation and culture protocol for these cells and subsequently established their metabolic status in vitro. Both IECs and PIs isolated from EMS horses were characterized by increased apoptosis and senescence. Moreover, they accumulated elevated levels of reactive oxygen species (ROS). Here we have observed that autophagy/mitophagy may be a protective mechanism which allows those cells to maintain their physiological function, clear protein aggregates and remove damaged organelles. Furthermore, it may play a crucial role in reducing endoplasmic reticulum (ER) stress. This protective mechanism may help to overcome the harmful effects of ROS and provide building blocks for protein and ATP synthesis.
C1 [Kornicka, Katarzyna; Smieszek, Agnieszka; Szlapka-Kosarzewska, Jolanta; Irwin Houston, Jennifer M.; Marycz, Krzysztof] Wroclaw Univ Environm & Life Sci, Dept Expt Biol, Fac Biol & Anim Sci, PL-50375 Wroclaw, Poland.
   [Irwin Houston, Jennifer M.] Postmatte 14, CH-8807 Freienbach, Switzerland.
   [Roecken, Michael; Marycz, Krzysztof] Justus Liebig Univ, Fac Vet Med, Equine Clin, Equine Surg, D-35392 Giessen, Germany.
C3 Wroclaw University of Environmental & Life Sciences; Justus Liebig
   University Giessen
RP Marycz, K (corresponding author), Wroclaw Univ Environm & Life Sci, Dept Expt Biol, Fac Biol & Anim Sci, PL-50375 Wroclaw, Poland.; Marycz, K (corresponding author), Justus Liebig Univ, Fac Vet Med, Equine Clin, Equine Surg, D-35392 Giessen, Germany.
EM kornicka.katarzyna@gmail.com; smieszek.agnieszka@gmail.com;
   jolanta.szlapka@gmail.com; d.weiss@horsedoc.ch; MRoecken@t-online.de;
   krzysztofmarycz@interia.pl
RI ; Smieszek, Agnieszka/A-4887-2017
OI Marycz, Krzysztof/0000-0003-3676-796X; Smieszek,
   Agnieszka/0000-0002-7314-9821
FU National Science Centre in Poland [2016/21/B/NZ7/01111,
   2015/18/E/NZ9/00607]; Wroclaw Centre of Biotechnology Leading National
   Research Centre (KNOW) program
FX The study was financed by the National Science Centre in Poland grants
   no 2016/21/B/NZ7/01111 and 2015/18/E/NZ9/00607. The publication was
   supported by the Wroclaw Centre of Biotechnology Leading National
   Research Centre (KNOW) program for the years 2014-2018.
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NR 56
TC 5
Z9 5
U1 0
U2 12
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD OCT
PY 2018
VL 19
IS 10
AR 3068
DI 10.3390/ijms19103068
PG 20
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA GY9HB
UT WOS:000448951000223
PM 30297648
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Morito, K
   Yamagata, M
   Naka, F
   Kobayashi, K
   Ueda, H
   Morimoto, H
   Yasukawa, T
   Takayama, K
   Uozumi, Y
   Nagasawa, K
AF Morito, Katsuya
   Yamagata, Mayu
   Naka, Futaba
   Kobayashi, Kayo
   Ueda, Hikari
   Morimoto, Hirotoshi
   Yasukawa, Takeshi
   Takayama, Kentaro
   Uozumi, Yoshinobu
   Nagasawa, Kazuki
TI Sub-chronic and mild social defeat stress exposure to C57BL/6J mice
   increases visceral fat mass and causes accumulation of cholesterol and
   bile acids in the liver
SO BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
LA English
DT Article
DE Metabolic disorder; Cholesterol; Bile acid; Gut microbiota; Mild
   psychosocial stress
ID MAJOR DEPRESSIVE DISORDER; ANIMAL-MODELS; MORTALITY; HEALTH;
   COMORBIDITY; MICROBIOTA; SECRETION; TRANSPORT; FEATURES; PATHWAY
AB Major depressive disorder is accompanied by a high metabolic illness comorbidity and patients with atypical depression are a subgroup with particularly high risk of obesity, dyslipidemia, and metabolic syndrome; however, the underlying mechanisms have not been fully elucidated. In this study, we examined visceral fat deposition, lipid profiles in the liver, and gut microbiota in sub-chronic and mild social defeat stress (sCSDS)-exposed C57BL/6J mice, which exhibit atypical depression-like phenotypes, i.e., increased body weight and food and water intake. We found that visceral fat mass and levels of hepatic cholesterol and bile acids in sCSDS-exposed mice were significantly increased compared to those in controls. The expression of hepatic small heterodimer partner, a negative regulator of cholesterol metabolism, was significantly elevated in sCSDS-exposed mice. We also found that gut microbial diversity and composition including lower relative abundance of Bacteroides spp. and Bifidobacterium spp. in sCSDS-exposed mice were different from those in controls. In addition, relative abundance of Bacteroides spp. and Bifidobacterium spp. was significantly and negatively correlated with body weight, visceral fat mass, and hepatic cholesterol and bile acids levels. These results indicate that sCSDS-exposure induces dysbiosis, and thereby contributes to metabolic disorder development.
C1 [Morito, Katsuya; Yamagata, Mayu; Naka, Futaba; Kobayashi, Kayo; Ueda, Hikari; Takayama, Kentaro; Nagasawa, Kazuki] Kyoto Pharmaceut Univ, Div Biol Sci, Lab Environm Biochem, 5 Misasaginakauchi Cho,Yamashina Ku, Kyoto 6078414, Japan.
   [Morimoto, Hirotoshi; Yasukawa, Takeshi; Uozumi, Yoshinobu] Ako Kasei Co Ltd, Tech Dev Div, 329 Sakoshi, Ako 6780193, Japan.
C3 Kyoto Pharmaceutical University
RP Nagasawa, K (corresponding author), Kyoto Pharmaceut Univ, Div Biol Sci, Lab Environm Biochem, 5 Misasaginakauchi Cho,Yamashina Ku, Kyoto 6078414, Japan.
EM nagasawa@mb.kyoto-phu.ac.jp
OI Takayama, Kentaro/0000-0002-9040-0539; Morimoto,
   Hirotoshi/0000-0002-4722-5966
FU Japan Society for the Promotion of Science (JSPS) [16K08284]
FX A part of this study was supported by a Grant -in -Aid for Scientific
   Research (KAKENHI) from Japan Society for the Promotion of Science
   (JSPS) [grant number 16K08284 (K & sdot; N.) ] .
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NR 58
TC 3
Z9 3
U1 1
U2 3
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0006-291X
EI 1090-2104
J9 BIOCHEM BIOPH RES CO
JI Biochem. Biophys. Res. Commun.
PD APR 2
PY 2024
VL 702
AR 149631
DI 10.1016/j.bbrc.2024.149631
EA FEB 2024
PG 9
WC Biochemistry & Molecular Biology; Biophysics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics
GA KZ8G2
UT WOS:001183876400001
PM 38335703
DA 2025-06-11
ER

PT J
AU Li, X
   Gao, ML
   Hua, J
AF Li, Xi
   Gao, Menglong
   Hua, Jiao
TI Comparative efficacy of various mind-body exercise types on
   cardiometabolic health in patients with type 2 diabetes: a network
   meta-analysis of randomized controlled trials
SO BMC CARDIOVASCULAR DISORDERS
LA English
DT Review
DE Type 2 diabetes mellitus; Mind-Body exercises; Cardiometabolic risk;
   Network Meta-Analysis; Randomized controlled trials
ID TAI-CHI; YOGA; STRESS; MEDITATION; MANAGEMENT; INTENSITY; STATEMENT;
   ADULTS
AB ObjectiveThis study aims to compare the efficacy of different mind-body exercises (MBEs) on cardiometabolic risk factors in patients with type 2 diabetes mellitus (T2DM) using a network meta-analysis of randomized controlled trials (RCTs).MethodsThis study followed PRISMA guidelines and was registered in PROSPERO (CRD42025630741). A systematic search of PubMed, Cochrane Library, Web of Science, and Embase was conducted up to December 15, 2024, using MeSH terms related to mind-body therapies and cardiometabolic risk in type 2 diabetes. Randomized controlled trials (RCTs) evaluating mind-body exercises (MBEs) on glucose metabolism, body composition, cardiovascular physiology, and lipid metabolism were included. Data extraction and risk of bias assessment (RoB 2 tool) were performed independently by two reviewers. Network meta-analysis was conducted using R (gemtc package) and Stata 17.0, with effect sizes reported as mean difference (MD) or standardized mean difference (SMD). Evidence quality was assessed using CINeMA.ResultsThis network meta-analysis compared the effects of various mind-body exercise interventions on ten cardiometabolic risk factors. Meditative Exercise (ME) was most effective in reducing fasting plasma glucose (SUCRA = 97.9%, SMD = -7.23, 95% CI: -8.27 to -6.20), while Mindfulness Intervention Training (MIT) showed the greatest benefit for glycated hemoglobin (SUCRA = 92.2%, MD = -0.78, 95% CI: -1.12 to -0.44) and blood pressure reduction (SBP: SUCRA = 86.1%, MD = -13.00, 95% CI: -17.22 to -8.78; DBP: SUCRA = 99.8%, MD = -6.00, 95% CI: -7.64 to -4.36), significantly outperforming conventional exercise. Yoga with Meditation (YWM) was most effective in lowering body mass index (SUCRA = 99.4%, MD = -2.90, 95% CI: -4.05 to -1.75). CINeMA assessments rated most comparisons as very low certainty due to within-study bias and between-study heterogeneity. Nevertheless, consistency was supported by node-splitting analysis, and no significant publication bias was detected, indicating robust and reliable findings.ConclusionCompared with conventional exercise intervention, MBE exerts unique and superior effects on various cardiometabolic risk factors in T2DM, underscoring their potential as effective and integrative interventions for personalized diabetes management. Clinicians should consider incorporating MBEs, such as MIT, ME, and YWM, into treatment plans based on individual patient needs, particularly for glycemic control, weight management, and cardiovascular health. Further research is warranted to explore the long-term benefits and optimal implementation strategies, especially given the heterogeneity in intervention protocols and the relatively short duration of the included trials.
C1 [Li, Xi] Wuxi Taihu Univ, Phys Educ Teaching Dept, Binhu Dist, Wuxi 214000, Jiangsu, Peoples R China.
   [Gao, Menglong] Daqing Normal Univ, Sch Phys Educ, Daqing, Heilongjiang, Peoples R China.
   [Hua, Jiao] Yangming Cent Primary Sch, Wuxi, Jiangsu, Peoples R China.
C3 Daqing Normal University
RP Li, X (corresponding author), Wuxi Taihu Univ, Phys Educ Teaching Dept, Binhu Dist, Wuxi 214000, Jiangsu, Peoples R China.
EM tiandiboy2000@163.com
RI gao, Menglong/KIH-3310-2024
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NR 92
TC 0
Z9 0
U1 2
U2 2
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1471-2261
J9 BMC CARDIOVASC DISOR
JI BMC Cardiovasc. Disord.
PD APR 17
PY 2025
VL 25
IS 1
AR 291
DI 10.1186/s12872-025-04745-1
PG 13
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 1PA7W
UT WOS:001470260800005
PM 40247204
OA gold
DA 2025-06-11
ER

PT J
AU Picano, E
   Pálinkás, A
   Amyot, R
AF Picano, E
   Pálinkás, A
   Amyot, R
TI Diagnosis of myocardial ischemia in hypertensive patients
SO JOURNAL OF HYPERTENSION
LA English
DT Review
DE diagnosis; echocardiography; electrocardiography; ischemia
ID LEFT-VENTRICULAR HYPERTROPHY; CORONARY-ARTERY DISEASE; DOBUTAMINE STRESS
   ECHOCARDIOGRAPHY; ANGINA-PECTORIS; CHEST PAIN;
   DIPYRIDAMOLE-ECHOCARDIOGRAPHY; SYNDROME-X; MICROVASCULAR DISEASE;
   SYSTEMIC HYPERTENSION; FLOW RESERVE
AB Arterial hypertension can provoke a reduction in coronary flow reserve through several mechanisms that are not mutually exclusive (i.e. epicardial coronary artery disease (CAD), left ventricular hypertrophy and structural and/or functional microvascular disease). These different targets of arterial hypertension should be explored with different diagnostic markers. In fact, stress-induced wall motion abnormalities are highly specific for angiographically assessed epicardial CAD, whereas ST segment depression and/or myocardial perfusion abnormalities are frequently found with angiographically normal coronary arteries associated with left ventricular hypertrophy and/or microvascular disease. Exercise-electrocardiography stress test can be used to screen patients with negative maximal test due to its excellent negative predictive value, which is high and comparable in normotensives and hypertensives. When exercise-electrocardiography stress test is positive (or uninterpretable or ambiguous), an imaging stress-echo test is warranted for a reliable identification of significant, prognostically malignant epicardial CAD in view of an ischemia-guided revascularization. (C) 2001 Lippincott Williams & Wilkins.
C1 CNR, Ist Fisiol Clin, I-56123 Pisa, Italy.
   Albert Szent Gyorgyi Med Univ, H-6701 Szeged, Hungary.
   Hop Sacre Coeur, Montreal, PQ H4J 1C5, Canada.
C3 Consiglio Nazionale delle Ricerche (CNR); Szeged University; Universite
   de Montreal
RP Picano, E (corresponding author), CNR, Ist Fisiol Clin, Via Moruzzi 1, I-56123 Pisa, Italy.
RI Picano, E/G-2261-2014
OI Palinkas, Attila/0000-0003-4839-7150
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NR 55
TC 79
Z9 81
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0263-6352
J9 J HYPERTENS
JI J. Hypertens.
PD JUL
PY 2001
VL 19
IS 7
BP 1177
EP 1183
DI 10.1097/00004872-200107000-00001
PG 7
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 447QK
UT WOS:000169583800001
PM 11446706
DA 2025-06-11
ER

PT J
AU Wang, YY
   Ye, CJ
   Kong, LJ
   Zheng, J
   Xu, M
   Xu, Y
   Li, M
   Zhao, ZY
   Lu, JL
   Chen, YH
   Wang, WQ
   Ning, G
   Bi, YF
   Wang, TE
AF Wang, Yiying
   Ye, Chaojie
   Kong, Lijie
   Zheng, Jie
   Xu, Min
   Xu, Yu
   Li, Mian
   Zhao, Zhiyun
   Lu, Jieli
   Chen, Yuhong
   Wang, Weiqing
   Ning, Guang
   Bi, Yufang
   Wang, Tiange
TI Independent Associations of Education, Intelligence, and Cognition With
   Hypertension and the Mediating Effects of Cardiometabolic Risk Factors:
   A Mendelian Randomization Study
SO HYPERTENSION
LA English
DT Article
DE cardiometabolic risk factors; cognition; education; hypertension;
   intelligence; mediation analyses; Mendelian randomization
ID INCIDENT HYPERTENSION; BLOOD-PRESSURE; CARDIOVASCULAR OUTCOMES;
   SOCIOECONOMIC-STATUS; WAIST CIRCUMFERENCE; METAANALYSIS; POTASSIUM;
   SMOKING; SODIUM; DYSLIPIDEMIA
AB Background:Education, intelligence, and cognition are associated with hypertension, but which one plays the most prominent role in the pathogenesis of hypertension and which modifiable risk factors mediate the causal effects remains unknown. Methods:Using summary statistics of genome-wide association studies of predominantly European ancestry, we conducted 2-sample multivariable Mendelian randomization to estimate the independent effects of education, intelligence, or cognition on hypertension (FinnGen study, 70 651 cases/223 663 controls; UK Biobank, 77 723 cases/330 366 controls) and blood pressure (International Consortium of Blood Pressure, 757 601 participants), and used 2-step Mendelian randomization to evaluate 25 potential mediators of the association and calculate the mediated proportions. Results:Meta-analysis of inverse variance weighted Mendelian randomization results from FinnGen and UK Biobank showed that genetically predicted 1-SD (4.2 years) higher education was associated with 44% (95% CI: 0.40-0.79) decreased hypertension risk and 1.682 mm Hg lower systolic and 0.898 mm Hg lower diastolic blood pressure, independently of intelligence and cognition. While the causal effects of intelligence and cognition on hypertension were not independent of education; 6 out of 25 cardiometabolic risk factors were identified as mediators of the association between education and hypertension, ranked by mediated proportions, including body mass index (mediated proportion: 30.1%), waist-to-hip ratio (22.8%), body fat percentage (14.1%), major depression (7.0%), high-density lipoprotein cholesterol (4.7%), and triglycerides (3.4%). These results were robust to sensitivity analyses. Conclusions:Our findings illustrated the causal, independent impact of education on hypertension and blood pressure and outlined cardiometabolic mediators as priority targets for prevention of hypertension attributable to low education.
C1 [Wang, Yiying; Ye, Chaojie; Kong, Lijie; Zheng, Jie; Xu, Min; Xu, Yu; Li, Mian; Zhao, Zhiyun; Lu, Jieli; Chen, Yuhong; Wang, Weiqing; Ning, Guang; Bi, Yufang; Wang, Tiange] Shanghai Jiao Tong Univ, Ruijin Hosp, Shanghai Inst Endocrine & Metab Dis, Dept Endocrine & Metab Dis,Sch Med, Shanghai, Peoples R China.
   [Wang, Yiying; Ye, Chaojie; Kong, Lijie; Zheng, Jie; Xu, Min; Xu, Yu; Li, Mian; Zhao, Zhiyun; Lu, Jieli; Chen, Yuhong; Wang, Weiqing; Ning, Guang; Bi, Yufang; Wang, Tiange] Shanghai Jiao Tong Univ, Ruijin Hosp, Shanghai Natl Clin Res Ctr Metab Dis, Key Lab Endocrine,Sch Med,Key Lab Endocrine & Met, Shanghai, Peoples R China.
   [Zheng, Jie] Univ Bristol, Bristol Med Sch, MRC Integrat Epidemiol Unit IEU, Bristol, England.
C3 Shanghai Jiao Tong University; Shanghai Jiao Tong University; University
   of Bristol
RP Zheng, J; Wang, TE (corresponding author), Shanghai Jiao Tong Univ, Ruijin Hosp, Shanghai Inst Endocrine & Metab Dis, Dept Endocrine & Metab Dis,Sch Med, Shanghai, Peoples R China.
EM jie.jheng@bristol.ac.uk; tiange.wang@shsmu.edu.cn
RI Zhiyun, Zhao/ABH-9036-2020; lu, jieli/JJG-0395-2023; Wang,
   Tiange/MCX-9826-2025; bi, yu/JOK-3859-2023; Martinez, Ramfis/I-7205-2019
OI Wang, Tiange/0000-0003-0723-489X; Zhao, Zhiyun/0000-0001-5950-2732
FU National Natural Science Foundation of China [82022011, 81970706,
   82088102, 81970728, 81941017]; Chinese Academy of Medical Sciences
   [2018PT32017, 2019PT330006]; "Shanghai Municipal Education
   Commission-Gaofeng Clinical Medicine Grant Support" from Shanghai Jiao
   Tong University School of Medicine [20171901]; Innovative Research Team
   of High-level Local Universities in Shanghai; Shanghai Shenkang Hospital
   Development Center [SHDC12019101, SHDC2020CR1001A, SHDC2020CR3064B];
   Shanghai Jiao Tong University School of Medicine [DLY201801]; Shanghai
   Clinical Research Center for Metabolic Disease [19MC1910100]; Ruijin
   Hospital [2018CR002]
FX This work was supported by the grants from the National Natural Science
   Foundation of China (82022011, 81970706, 82088102, 81970728, 81941017),
   the Chinese Academy of Medical Sciences (2018PT32017, 2019PT330006), the
   "Shanghai Municipal Education Commission-Gaofeng Clinical Medicine Grant
   Support" from Shanghai Jiao Tong University School of Medicine (20171901
   Round 2), the Innovative Research Team of High-level Local Universities
   in Shanghai, the Shanghai Shenkang Hospital Development Center
   (SHDC12019101, SHDC2020CR1001A, SHDC2020CR3064B), the Shanghai Jiao Tong
   University School of Medicine (DLY201801), the Ruijin Hospital
   (2018CR002), and Shanghai Clinical Research Center for Metabolic Disease
   (19MC1910100).
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NR 65
TC 54
Z9 54
U1 13
U2 65
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0194-911X
EI 1524-4563
J9 HYPERTENSION
JI Hypertension
PD JAN
PY 2023
VL 80
IS 1
BP 192
EP 203
DI 10.1161/HYPERTENSIONAHA.122.20286
PG 12
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 6U2DY
UT WOS:000894180700021
PM 36353998
OA hybrid, Green Published
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Guo, LH
   Zeeshan, M
   Huang, GF
   Chen, DH
   Xie, M
   Liu, J
   Dong, GH
AF Guo, Li-Hao
   Zeeshan, Mohammed
   Huang, Guo-Feng
   Chen, Duo-Hong
   Xie, Min
   Liu, Jun
   Dong, Guang-Hui
TI Influence of Air Pollution Exposures on Cardiometabolic Risk Factors: a
   Review
SO CURRENT ENVIRONMENTAL HEALTH REPORTS
LA English
DT Review
DE Cardiometabolic risk factors; Air pollution; Particulate matter
ID LONG-TERM EXPOSURE; FINE PARTICULATE MATTER; CARDIOVASCULAR-DISEASE;
   INSULIN-RESISTANCE; HYPERTENSION; HEALTH; ADULTS; CHINA; NOISE;
   DYSLIPIDEMIA
AB Purpose of ReviewThe increasing prevalence of cardiometabolic risk factors (CRFs) contributes to the rise in cardiovascular disease. Previous research has established a connection between air pollution and both the development and severity of CRFs. Given the ongoing impact of air pollution on human health, this review aims to summarize the latest research findings and provide an overview of the relationship between different types of air pollutants and CRFs.Recent FindingsCRFs include health conditions like diabetes, obesity, hypertension etc. Air pollution poses significant health risks and encompasses a wide range of pollutant types, air pollutants, such as particulate matter (PM), nitrogen dioxide (NO2), sulfur dioxide (SO2), and ozone (O2). More and more population epidemiological studies have shown a positive correlation between air pollution and CRFs. Although various pollutants have diverse effects on specific cellular molecular pathways, their main influence is on oxidative stress, inflammation response, and impairment of endothelial function.SummaryMore and more studies have proved that air pollution can promote the occurrence and development of cardiovascular and metabolic risk factors, and the research on the relationship between air pollution and CRFs has grown intensively. An increasing number of studies are using new biological monitoring indicators to assess the occurrence and development of CRFs resulting from exposure to air pollution. Abnormalities in some important biomarkers in the population (such as homocysteine, uric acid, and C-reactive protein) caused by air pollution deserve more attention. Further research is warranted to more fully understand the link between air pollution and novel CRF biomarkers and to investigate potential prevention and interventions that leverage the mechanistic link between air pollution and CRFs.
C1 [Guo, Li-Hao; Zeeshan, Mohammed; Dong, Guang-Hui] Sun Yat Sen Univ, Guangdong Prov Engn Technol Res Ctr Environm Pollu, Sch Publ Hlth, Dept Occupat & Environm Hlth, 74 Zhongshan 2Nd Rd, Guangzhou 510080, Peoples R China.
   [Huang, Guo-Feng; Chen, Duo-Hong; Xie, Min; Liu, Jun] Guangdong Ecol Environm Monitoring Ctr, State Environm Protect Key Lab Reg Air Qual Monito, Guangdong Environm Protect Key Lab Atmospher Secon, Guangzhou 510308, Peoples R China.
C3 Sun Yat Sen University
RP Dong, GH (corresponding author), Sun Yat Sen Univ, Guangdong Prov Engn Technol Res Ctr Environm Pollu, Sch Publ Hlth, Dept Occupat & Environm Hlth, 74 Zhongshan 2Nd Rd, Guangzhou 510080, Peoples R China.
EM guolh7@mail2.sysu.edu.cn; mdzeesh@gmail.com; 49399439@qq.com;
   13710967699@139.com; xieminsysu@163.com; 13798090760@139.com;
   donggh5@mail.sysu.edu.cn
RI MD, ZEESHAN/IZE-1107-2023; Dong, Guanghui/AAN-4630-2020; Guo,
   LiHao/KCK-6815-2024; Xu, Zhicheng/AAQ-8120-2021
FU National Natural Science Foundation of China
FX No Statement Available
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NR 93
TC 8
Z9 8
U1 8
U2 37
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
EI 2196-5412
J9 CURR ENV HLTH REP
JI Curr. Environ. Health Rep.
PD DEC
PY 2023
VL 10
IS 4
BP 501
EP 507
DI 10.1007/s40572-023-00423-6
EA NOV 2023
PG 7
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA GA1A2
UT WOS:001118406700001
PM 38030873
DA 2025-06-11
ER

PT J
AU Iversen, LB
   Strandberg-Larsen, K
   Prescott, E
   Schnohr, P
   Rod, NH
AF Iversen, Louise Bagger
   Strandberg-Larsen, Katrine
   Prescott, Eva
   Schnohr, Peter
   Rod, Naja Hulvej
TI Psychosocial risk factors, weight changes and risk of obesity: the
   Copenhagen City Heart Study
SO EUROPEAN JOURNAL OF EPIDEMIOLOGY
LA English
DT Article
DE Life change events; Obesity; Body mass index; Psychological stress;
   Prospective studies; Social support
ID BODY-MASS INDEX; MYOCARDIAL-INFARCTION; METABOLIC SYNDROME; VITAL
   EXHAUSTION; EATING BEHAVIOR; WORK STRESS; LIFE EVENTS; JOB STRAIN;
   ADULTS; CORTISOL
AB The aim of the study was to establish the effects of a range of psychosocial factors on weight changes and risk of obesity. The study population consisted of the 4,753 participants in the third (1991-1994) and fourth wave (2001-2003) of the Copenhagen City Heart Study, Denmark. At baseline the participants were asked comprehensive questions on major life events, work stress, vital exhaustion, social network, economic hardship, and intake of sleep medication. Weight and height were measured by health professionals. Weight changes and incident obesity was used as outcome measures. The participants on average gained 2 kg of weight and 8% became obese during follow-up. The experience of major life events in childhood, work life and adult life was associated with weight gain and obesity in women, but not in men. Vital exhaustion was associated with weight gain in a dose-response manner in men (P = 0.002) and younger women (P = 0.02). Persons with high vital exhaustion gained approximately 2 kg more during follow-up compared to those with no vital exhaustion. Women with high vital exhaustion were also more likely to become obese during follow-up (OR = 2.39; 95% CI: 1.14-5.03). There were no clear patterns in the associations between social network, economic hardship and weight gain or obesity. The number of psychosocial risk factors, as an indicator for clustering, was not associated with weight gain or obesity. In conclusion, major life events and vital exhaustion seem to play a role for weight gain and risk of obesity, especially in women.
C1 [Iversen, Louise Bagger; Strandberg-Larsen, Katrine; Rod, Naja Hulvej] Univ Copenhagen, Dept Publ Hlth, DK-1014 Copenhagen K, Denmark.
   [Prescott, Eva] Bispebjerg Hosp, Dept Cardiol, Copenhagen, Denmark.
   [Prescott, Eva; Schnohr, Peter] Bispebjerg Hosp, Epidemiol Res Unit, Copenhagen, Denmark.
C3 University of Copenhagen; University of Copenhagen; Copenhagen
   University Hospital; Bispebjerg Hospital; University of Copenhagen;
   Copenhagen University Hospital; Bispebjerg Hospital
RP Rod, NH (corresponding author), Univ Copenhagen, Dept Publ Hlth, Oster Farimagsgade 5,Postbox 2099, DK-1014 Copenhagen K, Denmark.
EM nahuro@sund.ku.dk
RI Strandberg-Larsen, Katrine/AAX-2063-2021; Prescott, Eva/AAJ-7441-2020;
   Rod, Naja Hulvej/B-9411-2015
OI Rod, Naja Hulvej/0000-0002-6400-5105; Strandberg-Larsen,
   Katrine/0000-0001-7061-3767; Prescott, Eva/0000-0002-4134-0349
FU Danish Medical Research Council [09-062115]; Danish Heart Foundation;
   Lundbeck Foundation
FX We thank the staff and the participants of the Copenhagen City Heart
   Study. This work was supported by the Danish Medical Research Council
   [09-062115 to L. B. I and N.H.R.]. The Copenhagen City Heart Study is
   supported by funds from the Danish Heart Foundation and the Lundbeck
   Foundation.
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NR 35
TC 28
Z9 32
U1 0
U2 27
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0393-2990
J9 EUR J EPIDEMIOL
JI Eur. J. Epidemiol.
PD FEB
PY 2012
VL 27
IS 2
BP 119
EP 130
DI 10.1007/s10654-012-9659-9
PG 12
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA 912YV
UT WOS:000301839200006
PM 22350224
DA 2025-06-11
ER

PT J
AU Haba-Rubio, J
   Marques-Vidal, P
   Andries, D
   Tobback, N
   Preisig, M
   Vollenweider, P
   Waeber, G
   Luca, G
   Tafti, M
   Heinzer, R
AF Haba-Rubio, Jose
   Marques-Vidal, Pedro
   Andries, Daniela
   Tobback, Nadia
   Preisig, Martin
   Vollenweider, Peter
   Waeber, Gerard
   Luca, Gianina
   Tafti, Mehdi
   Heinzer, Raphael
TI Objective Sleep Structure and Cardiovascular Risk Factors in the General
   Population: The HypnoLaus Study
SO SLEEP
LA English
DT Article
DE diabetes; hypertension; metabolic syndrome; obesity; polysomnography
ID ALL-CAUSE MORTALITY; SLOW-WAVE SLEEP; METABOLIC SYNDROME; DURATION;
   ASSOCIATION; OBESITY; APNEA; METAANALYSIS; HYPERTENSION; INSOMNIA
AB Study Objectives: To evaluate the association between objective sleep measures and metabolic syndrome (MS), hypertension, diabetes, and obesity.
   Design: Cross-sectional study.
   Setting: General population sample.
   Participants: There were 2,162 patients (51.2% women, mean age 58.4 +/- 11.1).
   Interventions: Patients were evaluated for hypertension, diabetes, overweight/obesity, and MS, and underwent a full polysomnography (PSG).
   Measurements and Results: PSG measured variables included: total sleep time (TST), percentage and time spent in slow wave sleep (SWS) and in rapid eye movement (REM) sleep, sleep efficiency and arousal index (ArI). In univariate analyses, MS was associated with decreased TST, SWS, REM sleep, and sleep efficiency, and increased ArI. After adjustment for age, sex, smoking, alcohol, physical activity, drugs that affect sleep and depression, the ArI remained significantly higher, but the difference disappeared in patients without significant sleep disordered breathing (SDB). Differences in sleep structure were also found according to the presence or absence of hypertension, diabetes, and overweight/obesity in univariate analysis. However, these differences were attenuated after multivariate adjustment and after excluding subjects with significant SDB.
   Conclusions: In this population-based sample we found significant associations between sleep structure and metabolic syndrome (MS), hypertension, diabetes, and obesity. However, these associations were cancelled after multivariate adjustment. We conclude that normal variations in sleep contribute little if any to MS and associated disorders.
C1 [Haba-Rubio, Jose; Andries, Daniela; Tobback, Nadia; Tafti, Mehdi; Heinzer, Raphael] Lausanne Univ Hosp CHUV, CIRS, CH-1011 Lausanne, Switzerland.
   [Marques-Vidal, Pedro] Lausanne Univ Hosp CHUV, Inst Social & Prevent Med IUMSP, CH-1011 Lausanne, Switzerland.
   [Preisig, Martin] Lausanne Univ Hosp CHUV, Dept Psychiat, CH-1011 Lausanne, Switzerland.
   [Vollenweider, Peter; Waeber, Gerard] Lausanne Univ Hosp CHUV, Dept Med, Internal Med, CH-1011 Lausanne, Switzerland.
   [Vollenweider, Peter; Waeber, Gerard] Fac Biol & Med, Lausanne, Switzerland.
   [Luca, Gianina; Tafti, Mehdi] Univ Lausanne, Ctr Integrat Genom, CH-1015 Lausanne, Switzerland.
   [Heinzer, Raphael] Lausanne Univ Hosp CHUV, Pulm Dept, CH-1011 Lausanne, Switzerland.
C3 University of Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV);
   University of Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV);
   University of Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV);
   University of Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV);
   University of Lausanne; University of Lausanne; Centre Hospitalier
   Universitaire Vaudois (CHUV)
RP Haba-Rubio, J (corresponding author), Lausanne Univ Hosp CHUV, CIRS, CH-1011 Lausanne, Switzerland.
EM jose.haba-rubio@chuv.ch
RI Luca, Gianina/ABE-3935-2020; Preisig, Martin/H-3441-2016; Vollenweider,
   Peter/Q-4603-2016; Marques-Vidal, Pedro/C-9449-2009; Tafti,
   Mehdi/A-8887-2017
OI Vollenweider, Peter/0000-0002-0765-896X; haba-rubio,
   jose/0000-0001-7466-6436; Waeber, Gerard/0000-0003-4193-788X;
   Marques-Vidal, Pedro/0000-0002-4548-8500; Preisig,
   Martin/0000-0001-5689-4259; Tafti, Mehdi/0000-0002-6997-3914; Heinzer,
   Raphael/0000-0002-3215-7788
FU Leenards Foundation; Ligue Pulmonaire Vaudoise; CIRS; GlaxoSmithKline;
   Swiss National Science Foundation [105993, 118308, 139468, 122661];
   Academy of Finland (AKA) [122661] Funding Source: Academy of Finland
   (AKA)
FX The HypnoLaus study was supported by grants from the Swiss National
   Science Foundation, the Leenards Foundation, the Ligue Pulmonaire
   Vaudoise, the CIRS, and GlaxoSmithKline. The CoLaus/PsyCoLaus study was
   supported by four grants of the Swiss National Science Foundation
   (#105993, 118308, 139468 and 122661) and two unrestricted grants from
   GlaxoSmithKline. The funders had no role in study design, data
   collection and analysis, decision to publish, or preparation of the
   manuscript. The authors have indicated no financial conflicts of
   interest.
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NR 44
TC 43
Z9 44
U1 2
U2 17
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0161-8105
EI 1550-9109
J9 SLEEP
JI Sleep
PD MAR
PY 2015
VL 38
IS 3
BP 391
EP +
DI 10.5665/sleep.4496
PG 13
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology
GA CC8WE
UT WOS:000350648500010
PM 25325467
OA Bronze, Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Seibert, P
   Anklam, CFV
   Costa-Beber, LC
   Sulzbacher, LM
   Sulzbacher, MM
   Sangiovo, AMB
   dos Santos, FK
   Goettems-Fiorin, PB
   Heck, TG
   Frizzo, MN
   Ludwig, MS
AF Seibert, Priscila
   Anklam, Carolain Felipin Vincensi
   Costa-Beber, Lilian Correa
   Sulzbacher, Lucas Machado
   Sulzbacher, Maicon Machado
   Sangiovo, Angela Maria Blanke
   dos Santos, Fernanda Knopp
   Goettems-Fiorin, Pauline Brendler
   Heck, Thiago Gomes
   Frizzo, Matias Nunes
   Ludwig, Mirna Stela
TI Increased eHSP70-to-iHSP70 ratio in prediabetic and diabetic
   postmenopausal women: a biomarker of cardiometabolic risk
SO CELL STRESS & CHAPERONES
LA English
DT Article
DE Menopause; H-index; Glycemia; HSP70; Diabetes
ID HEAT-SHOCK PROTEINS; NF-KAPPA-B; BLOOD-CELL COUNT; INSULIN-RESISTANCE;
   OXIDATIVE STRESS; IN-VIVO; INFLAMMATION; EXERCISE; GLUCOSE; INDEX
AB Decreased estrogen levels in menopause are associated with anthropometric, metabolic, and inflammatory impairments, predisposing women to cardiometabolic risk factors such as diabetes. Menopause and type two diabetes (DM2) are marked by altered heat shock response (HSR), shown by decreased expression of the 70-kDa heat shock protein in the intracellular milieu (iHSP70). While iHSP70 plays an anti-inflammatory role, extracellular HSP70 (eHSP70) may mediate pro-inflammatory pathways and has been associated with insulin resistance in DM2. Considering the roles of these proteins according to localization, the eHSP70-to-iHSP70 ratio (H-index) has been proposed as a biomarker for HSR. We, therefore, evaluated whether this biomarker is associated with glycemic and inflammatory status in postmenopausal women. In this transversal study, 36 postmenopausal women were grouped according to fasting glycemia status as either the control group (normoglycemic, <= 99 mg/dL) or DM2 (prediabetic and diabetic, glycemia >= 100 mg/dL). DM2 group showed higher triglyceride/glucose (TyG) index and plasma atherogenic index (PAI), both of which are indicators of cardiometabolic risk. In addition, we found that the eHSP70-to-iHSP70 ratio (plasma/peripheral blood mononuclear cells-PBMC ratio) was higher in the DM2 group, compared with the control group. Furthermore, blood leukocyte and glycemia levels were positively correlated with the eHSP70-to-iHSP70 ratio in women that presented H-index values above 1.0 (a.u.). Taken together, our results highlight the eHSP70-to-iHSP70 ratio as a biomarker of altered HSR in DM2 postmenopausal women.
C1 [Seibert, Priscila; Anklam, Carolain Felipin Vincensi; Costa-Beber, Lilian Correa; Sulzbacher, Lucas Machado; Sulzbacher, Maicon Machado; Sangiovo, Angela Maria Blanke; dos Santos, Fernanda Knopp; Goettems-Fiorin, Pauline Brendler; Heck, Thiago Gomes; Frizzo, Matias Nunes; Ludwig, Mirna Stela] Reg Univ Northwestern Rio Grande Do Sul State UNI, Res Grp Physiol, Ijui, RS, Brazil.
   [Seibert, Priscila; Anklam, Carolain Felipin Vincensi; Costa-Beber, Lilian Correa; Sulzbacher, Lucas Machado; Sulzbacher, Maicon Machado; Sangiovo, Angela Maria Blanke; Goettems-Fiorin, Pauline Brendler; Heck, Thiago Gomes; Frizzo, Matias Nunes; Ludwig, Mirna Stela] Reg Univ Northwestern Rio Grande Do Sul State, Res Grp Physiol, Post Grad Program Integral Attent Hlth, Rua Comercio 3000, BR-98700000 Ijui, RS, Brazil.
   [Sulzbacher, Maicon Machado] Fed Univ Santa Maria UFSM, Post Grad Program Pharmacol, Santa Maria, RS, Brazil.
   [Heck, Thiago Gomes] Post Grad Program Math & Computat Modeling PPGMMC, Ijui, RS, Brazil.
C3 Universidade Federal de Santa Maria (UFSM)
RP Heck, TG (corresponding author), Reg Univ Northwestern Rio Grande Do Sul State UNI, Res Grp Physiol, Ijui, RS, Brazil.; Heck, TG (corresponding author), Reg Univ Northwestern Rio Grande Do Sul State, Res Grp Physiol, Post Grad Program Integral Attent Hlth, Rua Comercio 3000, BR-98700000 Ijui, RS, Brazil.
EM thiago.heck@unijui.edu.br; ludwig@unijui.edu.br
RI Machado Sulzbacher, Maicon/CAF-1600-2022; Costa-Beber,
   Lílian/AAH-2123-2020; Heck, Thiago/D-2251-2011; Brendler Goettems
   Fiorin, Pauline/HSB-7904-2023
OI Machado Sulzbacher, Maicon/0000-0002-9375-0745; Heck,
   Thiago/0000-0002-1242-5423; Brendler Goettems Fiorin,
   Pauline/0000-0002-4418-568X
FU Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior -Brasil
   (CAPES); Regional University of the Northwestern Rio Grande do Sul State
   (UNIJUI); Brazilian National Council for Scientific and Technological
   Development (UNIVERSAL MCTI/CNPq 28/2018) [427559/2018-9]; CAPES;
   PROPG-UNIJUI
FX This study was financed in part by the Coordenacao de Aperfeicoamento de
   Pessoal de Nivel Superior -Brasil (CAPES), the Regional University of
   the Northwestern Rio Grande do Sul State (UNIJUI), and by grants awarded
   to MSL from The Brazilian National Council for Scientific and
   Technological Development (UNIVERSAL MCTI/CNPq 28/2018 process
   #427559/2018-9). MMS, LMS, and LCCB were recipients of scholarships from
   CAPES. AMBS and PS were recipients of scholarships from PROPG-UNIJUI.
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   Tsuzuki T, 2017, CELL STRESS CHAPERON, V22, P263, DOI 10.1007/s12192-017-0767-z
   VALDEZ R, 1991, J CLIN EPIDEMIOL, V44, P955, DOI 10.1016/0895-4356(91)90059-I
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NR 73
TC 7
Z9 7
U1 0
U2 4
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1355-8145
EI 1466-1268
J9 CELL STRESS CHAPERON
JI Cell Stress Chaperones
PD SEP
PY 2022
VL 27
IS 5
BP 523
EP 534
DI 10.1007/s12192-022-01288-8
EA JUN 2022
PG 12
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA 4P5ZI
UT WOS:000818584500001
PM 35767179
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Vetrani, C
   Vitale, M
   Bozzetto, L
   Della Pepa, G
   Cocozza, S
   Costabile, G
   Mangione, A
   Cipriano, P
   Annuzzi, G
   Rivellese, AA
AF Vetrani, Claudia
   Vitale, Marilena
   Bozzetto, Lutgarda
   Della Pepa, Giuseppe
   Cocozza, Sara
   Costabile, Giuseppina
   Mangione, Anna
   Cipriano, Paola
   Annuzzi, Giovanni
   Rivellese, Angela A.
TI Association between different dietary polyphenol subclasses and the
   improvement in cardiometabolic risk factors: evidence from a randomized
   controlled clinical trial
SO ACTA DIABETOLOGICA
LA English
DT Article
DE Flavonoids; Phenolic acids; Lipid response; Glucose homeostasis; Urinary
   isoprostanes
ID GLUCOSE-METABOLISM; HEALTHY HUMANS; FLAVONOIDS; INTERVENTION;
   ANTIOXIDANT; CELLS; TEA
AB Due to their different chemical structures and metabolism, polyphenol subclasses may have specific impact on cardiometabolic risk factors. Our aim was to evaluate whether the intake of different polyphenol subclasses is associated with clinical outcomes beneficially improved by polyphenols in a nutritional trial performed by our group (postprandial lipid response, glucose homeostasis, early insulin secretion and oxidative stress).
   The present study is a secondary analysis of a nutritional intervention study with a diet naturally rich in polyphenols. The data are derived from 78 participants at high cardiovascular risk who completed the ETHERPATH trial. The associations between variations in polyphenol subclasses (phenolic acids, anthocyanidins, flavones, flavan-3-ols, flavonols and flavanones) and clinical outcomes beneficially influenced by polyphenols were firstly explored by Spearman's correlation. Thereafter, adjustment for gender, age and body mass index (BMI) was run. Linear regression analysis was used to assess the class of polyphenols that best predicted the outcome.
   Flavanone intake was inversely correlated with postprandial lipid response, whereas flavone intake was related to postchallenge glucose response. Anthocyanidins and flavan-3-ols associated positively with early insulin secretion. The decrease in urinary isoprostanes correlated with anthocyanidins, flavan-3-ols and flavonols. Correlations did not change after adjustment for gender, age, and BMI. Linear regression analysis showed an independent association between flavonols and urinary isoprostanes, whereas early insulin secretion was mainly associated with flavan-3-ols intake.
   The results of this study show that a polyphenol-rich diet may have a pleiotropic effect on cardiometabolic risk factors thanks to the specific action of different polyphenol subclasses.
C1 [Vetrani, Claudia; Vitale, Marilena; Bozzetto, Lutgarda; Della Pepa, Giuseppe; Cocozza, Sara; Costabile, Giuseppina; Mangione, Anna; Cipriano, Paola; Annuzzi, Giovanni; Rivellese, Angela A.] Univ Naples Federico II, Dept Clin Med & Surg, 5 Sergio Pansini, I-80131 Naples, Italy.
C3 University of Naples Federico II
RP Rivellese, AA (corresponding author), Univ Naples Federico II, Dept Clin Med & Surg, 5 Sergio Pansini, I-80131 Naples, Italy.
EM rivelles@unina.it
RI Bozzetto, Lutgarda/E-6271-2012; Della Pepa, Giuseppe/AAK-5488-2020;
   Costabile, Giuseppina/K-4589-2016; Ciampalini, Paolo/K-4366-2016;
   Vetrani, Claudia/D-3306-2018; Vitale, Marilena/J-1457-2014
OI Vetrani, Claudia/0000-0001-8335-5939; Vitale,
   Marilena/0000-0001-9951-4674; Costabile, Giuseppina/0000-0001-5761-8002;
   Della Pepa, Giuseppe/0000-0001-5862-3794
FU European Community [FP7-KBBE-222639]; "Ministero dell'Istruzione,
   dell'Universita e della Ricerca," Rome, Italy [PRIN
   2010-2011-2010JCWWKM]
FX The trial was supported by European Community's Seventh Framework
   Programme FP7/2009-2012 under grant agreement FP7-KBBE-222639,
   Etherpaths Project and by "Ministero dell'Istruzione, dell'Universita e
   della Ricerca," Rome, Italy, PRIN 2010-2011-2010JCWWKM. We gratefully
   acknowledge Angela Giacco for skillful dietary assistance.
CR Annuzzi G, 2014, AM J CLIN NUTR, V99, P463, DOI 10.3945/ajcn.113.073445
   Assini JM, 2013, CURR OPIN LIPIDOL, V24, P34, DOI 10.1097/MOL.0b013e32835c07fd
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   Vetrani C, 2014, FOOD RES INT, V63, P233, DOI 10.1016/j.foodres.2014.01.018
NR 20
TC 41
Z9 41
U1 0
U2 21
PU SPRINGER-VERLAG ITALIA SRL
PI MILAN
PA VIA DECEMBRIO, 28, MILAN, 20137, ITALY
SN 0940-5429
EI 1432-5233
J9 ACTA DIABETOL
JI Acta Diabetol.
PD FEB
PY 2018
VL 55
IS 2
BP 149
EP 153
DI 10.1007/s00592-017-1075-x
PG 5
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA FW4JM
UT WOS:000425279400005
PM 29151225
DA 2025-06-11
ER

PT J
AU Wilson, CE
   Carpenter, JS
   Crouse, JJ
   Park, S
   Koethe, D
   Scott, EM
   Hickie, IB
AF Wilson, Chloe E.
   Carpenter, Joanne S.
   Crouse, Jacob J.
   Park, Shin
   Koethe, Dagmar
   Scott, Elizabeth M.
   Hickie, Ian B.
TI Cross-sectional and longitudinal associations between cardiometabolic
   measures and clinical stage in young people accessing early intervention
   mental health services
SO EARLY INTERVENTION IN PSYCHIATRY
LA English
DT Article
DE cardiometabolic measures; clinical staging; insulin-resistance; obesity;
   youth mental disorders
ID INSULIN-RESISTANCE; METABOLIC SYNDROME; OBESITY; CHILD; MODEL
AB AimThis retrospective cohort study aimed to identify the cardiometabolic characteristics, cross-sectionally and longitudinally, associated with clinical stage in youth accessing early intervention mental health services. MethodsCardiometabolic data we collected in 511 young people (aged 12-25 years at entry) receiving mental health care at the early intervention services in Sydney, Australia. ResultsThe majority of young people (N = 448, 87.67%) were classified in stage 1a or 1b at entry. At entry to care, there was no cross-sectional relationship between clinical stage and age, gender, fasting insulin, fasting glucose, updated homeostatic model assessment for insulin resistance (HOMA2-IR) score, BMI or waist circumference. Of the 111 (21.7%) young people initially classified at stage 1a ('non-specific symptoms') and the 337 (65.9%) classified in stage 1b ('attenuated syndromes'), 40 individuals transitioned to stage 2+ (7.8%) ("full-threshold disorders") longitudinally. No cardiometabolic factors predicted clinical stage transitions. However, those with an increase in BMI over the course of care (n = 54) were 1.46 (OR; 95% CI: 1.02-2.17) times more likely to progress to stage 2+ at follow up. ConclusionsWhilst no relationships were found between demographic or cardiometabolic variables and clinical stage at entry to care, an increased BMI over time was associated with clinical stage transition longitudinally. Further longitudinal research is needed to understand the demographic, clinical, illness progression or treatment factors associated with changes in cardiometabolic status.
C1 [Wilson, Chloe E.; Carpenter, Joanne S.; Crouse, Jacob J.; Park, Shin; Koethe, Dagmar; Scott, Elizabeth M.; Hickie, Ian B.] Univ Sydney, Brain & Mind Ctr, Youth Mental Hlth & Technol Team, Camperdown, Australia.
   [Wilson, Chloe E.] Univ Sydney, Brain & Mind Ctr, 94 Mallett St, Camperdown, Australia.
C3 University of Sydney; University of Sydney
RP Wilson, CE (corresponding author), Univ Sydney, Brain & Mind Ctr, 94 Mallett St, Camperdown, Australia.
EM chloe.wilson@sydney.edu.au
RI Carpenter, Joanne/HZK-3629-2023; Crouse, Jacob/ABS-5367-2022; Hickie,
   Ian/K-8975-2015; Koethe, Dagmar/G-2462-2014
OI Scott, Elizabeth/0000-0003-3907-0324; , Chloe/0000-0001-6539-423X; Park,
   Shin Ho/0000-0002-1309-0506; Hickie, Ian/0000-0001-8832-9895; Crouse,
   Jacob/0000-0002-3805-2936; Carpenter, Joanne/0000-0002-9766-6700;
   Koethe, Dagmar/0000-0002-8324-6756
FU University of Sydney; Liu McCabe Family Scholarship; National Health &
   Medical Research Council Australia [511921]; Caroline Quinn Research
   Grant; NHMRC; Breakthrough Mental Health Research Foundation
FX This project is an investigator-initiated study, sponsored by the
   University of Sydney and supported by philanthropic funding, for which
   donor(s) are families affected by mental illness who wish to remain
   anonymous. This study was also partially funded by a philanthropic PhD
   scholarship (The Liu McCabe Family Scholarship awarded to CEW), a
   National Health & Medical Research Council Australia Fellowship (511921,
   awarded to IBH) and a philanthropic fellowship (the Caroline Quinn
   Research Grant awarded to JSC). JJC is supported by a NHMRC Emerging
   Leadership Fellowship and a Breakthrough Mental Health Research
   Foundation Fellowship. The funders of this study had no involvement in
   the study design; collection, analysis and reporting of the data;
   writing of the report; or decision to submit the paper for publication.
CR Buppajarntham S., 2021, INSULIN
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NR 34
TC 1
Z9 1
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1751-7885
EI 1751-7893
J9 EARLY INTERV PSYCHIA
JI Early Interv. Psychiatry
PD SEP
PY 2023
VL 17
IS 9
BP 893
EP 900
DI 10.1111/eip.13381
EA JAN 2023
PG 8
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA R2IR0
UT WOS:000919056000001
PM 36682384
OA hybrid
DA 2025-06-11
ER

PT J
AU Taylor, WC
   Rix, K
   Gibson, A
   Paxton, RJ
AF Taylor, Wendell C.
   Rix, Kevin
   Gibson, Ashley
   Paxton, Raheem J.
TI Sedentary behavior and health outcomes in older adults: A systematic
   review
SO AIMS MEDICAL SCIENCE
LA English
DT Review
DE sedentary behavior; health; elderly; older adults; physical inactivity
ID PHYSICAL-ACTIVITY; SITTING TIME; CANCER; MORTALITY; SPENT; TOO
AB Introduction: Older adults (>= 60 years old) report prolonged periods of sedentary behavior. Sedentary behavior is a potential health hazard for this priority population. Therefore, we systematically reviewed the published literature to document the relationships among sedentary behaviors and twelve health outcomes ranging from mental health to mortality. Methods: Major databases were searched from 2013 to 2019; 27 relevant articles were found and evaluated. In addition, we compared our findings to a previously published review. Results: Higher levels of sedentary behavior were related to an increased risk of all-cause mortality and adversely associated with metabolic syndrome, triglycerides/high density lipoprotein cholesterol/blood glucose, HBA1C/glucose intolerance, waist circumference, and obesity/overweight when compared to those with lower levels of sedentary behavior. Findings for blood pressure, cancer, and mental health (e.g., dementia, mild cognitive impairment, psychological well-being) were insufficient to draw conclusions or had inconsistent results. Because some sedentary behaviors were protective for mental health, we recommend a taxonomy of sedentary behaviors for older adults to provide insights into these seemingly discrepant findings. Some of our findings were similar to a prior review while other findings were different. Conclusion: This systematic review identified the health outcomes that were sufficiently, insufficiently, or not affected by sedentary behavior. To advance the field, we recommend better methodological quality. To improve the overall health and wellbeing of older adults, future studies should evaluate interventions to decrease health-compromising and increase health-promoting sedentary behaviors among older adults.
C1 [Taylor, Wendell C.] Univ Texas Med Branch, Dept Prevent Med & Populat Hlth, Inst Med Humanities, Galveston, TX 77555 USA.
   [Rix, Kevin] Univ Texas Hlth Sci Ctr Houston, Sch Publ Hlth, Dept Hlth Promot & Behav Sci, Austin, TX USA.
   [Gibson, Ashley] Univ Texas Hlth Sci Ctr Houston, Cizik Sch Nursing, Dept Grad Studies, Houston, TX 77030 USA.
   [Paxton, Raheem J.] Univ Alabama, Inst Rural Hlth Res, Dept Community Med & Populat Hlth, Tuscaloosa, AL USA.
C3 University of Texas System; University of Texas Medical Branch
   Galveston; University of Texas System; University of Texas Health
   Science Center Houston; University of Texas System; University of Texas
   Health Science Center Houston; University of Alabama System; University
   of Alabama Tuscaloosa
RP Taylor, WC (corresponding author), Univ Texas Med Branch, Dept Prevent Med & Populat Hlth, Inst Med Humanities, Galveston, TX 77555 USA.
EM wetaylor@utmb.edu
RI Paxton, Raheem/AAN-8842-2020
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NR 49
TC 16
Z9 17
U1 9
U2 50
PU AMER INST MATHEMATICAL SCIENCES-AIMS
PI SPRINGFIELD
PA PO BOX 2604, SPRINGFIELD, MO 65801-2604, UNITED STATES
SN 2375-1576
J9 AIMS MED SCI
JI AIMS Med. Sci.
PY 2020
VL 7
IS 1
BP 10
EP 39
DI 10.3934/medsci.2020002
PG 30
WC Medicine, Research & Experimental
WE Emerging Sources Citation Index (ESCI)
SC Research & Experimental Medicine
GA MJ9ZQ
UT WOS:000548445100002
OA gold
DA 2025-06-11
ER

PT J
AU Madden, SK
   Flanagan, KL
   Jones, G
AF Madden, Seonad K.
   Flanagan, Katie L.
   Jones, Graeme
TI How lifestyle factors and their associated pathogenetic mechanisms
   impact psoriasis
SO CLINICAL NUTRITION
LA English
DT Review
DE Psoriasis; Stress; Microbiota; Nutrition; Inflammation; Lifestyle
ID N-3 FATTY-ACIDS; INTESTINAL BACTERIAL OVERGROWTH; DIETARY
   SUPPLEMENTATION; METABOLIC SYNDROME; CLINICAL SEVERITY; ADIPOSE-TISSUE;
   DOUBLE-BLIND; VITAMIN-D; PSYCHOLOGICAL STRESS; LIPID-PEROXIDATION
AB Backgrounds and aims: Psoriasis is a skin disorder affecting approximately 2-3% of the global population. While research has revealed a strong genetic component, there are few studies exploring the extent to which lifestyle factors influence psoriasis pathogenesis. The aim of this review was to describe the role of lifestyle factors as both a potential cause and treatment for psoriasis. The review also examines the underlying mechanisms through which these lifestyle factors may operate.
   Methods: This narrative review aims to incorporate current knowledge relating to both lifestyle and pathogenetic factors that contribute to and alleviate psoriasis presentation. Studies reporting the effect of an inflammatory diet and potential dietary benefits are reported, as well as insights into the effects of stress, smoking and alcohol, insulin resistance and exercise.
   Results: Poor nutrition and low Omega 3 fatty acid intake, likely combined with fat malabsorption caused by gut dysbiosis and systemic inflammation, are associated with psoriasis. The data strongly suggest that improvements to disease severity can be made through dietary and lifestyle interventions and increased physical activity. Less conclusive, although worthy of mention, is the beneficial effect of bile acid supplementation.
   Conclusions: Lifestyle interventions are a promising treatment for psoriasis and its associated comorbidities. However, gaps and inadequacies exist within the literature, e.g. methodology, absence of a unified scoring system, lack of controlled clinical data and lack of studies without simultaneous usage of biologics or alternative therapies. Future directions should focus on high quality cohort studies and clinical trials. (C) 2019 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.
C1 [Madden, Seonad K.] Univ Tasmania, Coll Hlth & Med, Sch Hlth Sci, Sandy Bay, Tas, Australia.
   [Flanagan, Katie L.] Univ Tasmania, Coll Hlth & Med, Sch Med, Sandy Bay, Tas, Australia.
   [Flanagan, Katie L.] RMIT Univ, Sch Hlth & Biomed Sci, Melbourne, Vic, Australia.
   [Flanagan, Katie L.] Launceston Gen Hosp, Infect Dis Serv, Launceston, Tas, Australia.
   [Flanagan, Katie L.] Monash Univ, Dept Immunol & Pathol, Clayton, Vic, Australia.
   [Jones, Graeme] Univ Tasmania, Menzies Inst Med Res, Sandy Bay, Tas, Australia.
C3 University of Tasmania; University of Tasmania; Royal Melbourne
   Institute of Technology (RMIT); Launceston General Hospital; Monash
   University; University of Tasmania; Menzies Institute for Medical
   Research
RP Madden, SK (corresponding author), Univ Tasmania, Room 568,Humanities Bldg, Sandy Bay, Tas 7005, Australia.
EM seonad.madden@utas.edu.au
RI Jones, Graeme/J-7899-2014
OI Flanagan, Katie/0000-0002-1575-1953; jones, graeme/0000-0002-9814-0006;
   Madden, Seonad/0000-0002-6804-2667
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NR 158
TC 29
Z9 32
U1 1
U2 22
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0261-5614
EI 1532-1983
J9 CLIN NUTR
JI Clin. Nutr.
PD APR
PY 2020
VL 39
IS 4
BP 1026
EP 1040
DI 10.1016/j.clnu.2019.05.006
PG 15
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA LG1EZ
UT WOS:000527854300005
PM 31155371
DA 2025-06-11
ER

PT J
AU Kanbay, M
   Copur, S
   Demiray, A
   Sag, AA
   Covic, A
   Ortiz, A
   Tuttle, KR
AF Kanbay, Mehmet
   Copur, Sidar
   Demiray, Atalay
   Sag, Alan A.
   Covic, Adrian
   Ortiz, Alberto
   Tuttle, Kathherine R.
TI Fatty kidney: A possible future for chronic kidney disease research
SO EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
LA English
DT Review
DE chronic kidney disease; diabetes mellitus; fatty kidney; metabolic
   syndrome; novel therapy
ID TYPE-2 DIABETES-MELLITUS; PERIRENAL ADIPOSE-TISSUE; RENAL
   LIPID-METABOLISM; SCAVENGER RECEPTOR; INSULIN-RESISTANCE;
   BETA-OXIDATION; LIVER-DISEASE; SINUS FAT; OBESITY; CD36
AB Background Metabolic syndrome is a growing twenty-first century pandemic associated with multiple clinical comorbidities ranging from cardiovascular diseases, non-alcoholic fatty liver disease and polycystic ovary syndrome to kidney dysfunction. A novel area of research investigates the concept of fatty kidney in the pathogenesis of chronic kidney disease, especially in patients with diabetes mellitus or metabolic syndrome. Aim To review the most updated literature on fatty kidney and provide future research, diagnostic and therapeutic perspectives on a disease increasingly affecting the contemporary world. Materials and Method We performed an extensive literature search through three databases including Embase (Elsevier) and the Cochrane Central Register of Controlled Trials (Wiley) and PubMed/Medline Web of Science in November 2021 by using the following terms and their combinations: 'fatty kidney', 'ectopic fat', 'chronic kidney disease', 'cardiovascular event', 'cardio-metabolic risk', 'albuminuria' and 'metabolic syndrome'. Each study has been individually assessed by the authors. Results Oxidative stress and inflammation, Klotho deficiency, endoplasmic reticulum stress, mitochondrial dysfunction and disruption of cellular energy balance appear to be the main pathophysiological mechanisms leading to tissue damage following fat accumulation. Despite the lack of large-scale comprehensive studies in this novel field of research, current clinical trials demonstrate fatty kidney as an independent risk factor for the development of chronic kidney disease and cardiovascular events. Conclusion The requirement for future studies investigating the pathophysiology, clinical outcomes and therapeutics of fatty kidney is clear.
C1 [Kanbay, Mehmet] Koc Univ, Sch Med, Dept Med, Div Nephrol, Istanbul, Turkey.
   [Copur, Sidar; Demiray, Atalay] Koc Univ, Sch Med, Dept Med, Istanbul, Turkey.
   [Sag, Alan A.] Duke Univ, Med Ctr, Dept Radiol, Div Vasc & Intervent Radiol, Durham, NC USA.
   [Covic, Adrian] Grigore T Popa Univ Med, Dept Nephrol, Iasi, Romania.
   [Ortiz, Alberto] Univ Autonoma Madrid, Dept Med, Madrid, Spain.
   [Ortiz, Alberto] IIS Fdn Jimenez Diaz, Madrid, Spain.
   [Tuttle, Kathherine R.] Univ Washington, Div Nephrol, Seattle, WA 98195 USA.
   [Tuttle, Kathherine R.] Providence Med Res Ctr, Providence Hlth Care, Spokane, WA USA.
C3 Koc University; Koc University; Duke University; Grigore T Popa
   University of Medicine & Pharmacy; Autonomous University of Madrid;
   Fundacion Jimenez Diaz; University of Washington; University of
   Washington Seattle
RP Kanbay, M (corresponding author), Koc Univ, Sch Med, TR-34010 Istanbul, Turkey.
EM mkanbay@ku.edu.tr
RI 1, 1/IAO-4606-2023; Demiray, Atalay/AAR-1682-2021; Covic,
   Adrian/G-5017-2016
OI Sag, Alan Alper/0000-0002-3106-0458; Tuttle,
   Katherine/0000-0002-2235-0103; Kanbay, Mehmet/0000-0002-1297-0675;
   Demiray, Atalay/0000-0001-5503-5305
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NR 149
TC 12
Z9 12
U1 0
U2 13
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0014-2972
EI 1365-2362
J9 EUR J CLIN INVEST
JI Eur. J. Clin. Invest.
PD JUN
PY 2022
VL 52
IS 6
AR e13748
DI 10.1111/eci.13748
EA JAN 2022
PG 14
WC Medicine, General & Internal; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Research & Experimental Medicine
GA 1I4LK
UT WOS:000745859100001
PM 35040119
DA 2025-06-11
ER

PT J
AU Harralson, TL
   Emig, JC
   Polansky, M
   Walker, RE
   Cruz, JO
   Garcia-Leeds, C
AF Harralson, Tina L.
   Emig, Julie Cousler
   Polansky, Marcia
   Walker, Renee E.
   Cruz, Joanna Otero
   Garcia-Leeds, Claudia
TI Un corazon saludable: Factors influencing outcomes of an exercise
   program designed to impact cardiac and metabolic risks among urban
   Latinas
SO JOURNAL OF COMMUNITY HEALTH
LA English
DT Article
DE latino health; exercise; cardiovascular disease; metabolic syndrome
ID AMERICAN-HEART-ASSOCIATION; 3RD NATIONAL-HEALTH; PHYSICAL-ACTIVITY;
   DEPRESSIVE SYMPTOMS; WOMENS HEALTH; PREVALENCE; CARE; DISEASE
AB A high prevalence of physical inactivity, metabolic risk factors, and depression place Latinas in peril of developing cardiovascular disease. "Un Corazon Saludable: A Healthy Heart" was developed to engage urban Latinas in physical activity and increase awareness of cardiac and metabolic risk factors. Two hundred and twenty-five Latinas enrolled in the program that included salsa aerobics and culturally sensitive health education modules. Cardiac and metabolic risk factors measured in this study were body mass index (BMI), waist-to-hip ratio, abdominal obesity, and blood pressure. Psychosocial risk factors measured included depressive symptoms and perceived social support. Fifty-two percent of the enrollees completed the program. Results indicated decreases in BMI, abdominal obesity, and symptoms of depression among Latinas who completed the program. Those who did not complete the program were younger, had greater depressive symptomatology, reported poorer social support, and they tended to be caregivers and U.S. born. Focus groups of program participants ascertained that caregiving and family obligations were major barriers to exercise while social support was a major facilitator of exercise. This research indicates that programs developed to recognize and address cultural barriers can impact physical and psychosocial risk factors among urban Latinas who are able to attend. Program retention may improve if future exercise programs conducted through community-base organizations offered support to Latinas regarding issues that interfere with self-care and health promotion. Future programs should consider including mental health and social service case management as part of comprehensive exercise/educational programs.
C1 Einstein Ctr Urban Hlth Policy & Res, Philadelphia, PA 19144 USA.
   Congreso Latinos Unidos, Philadelphia, PA 19133 USA.
   Drexel Univ, Sch Publ Hlth, Philadelphia, PA 19104 USA.
C3 Drexel University
RP Harralson, TL (corresponding author), Einstein Ctr Urban Hlth Policy & Res, Wister Tower 1 Penn Blvd,Suite 4442, Philadelphia, PA 19144 USA.
EM harralsont@einstein.edu
RI Walker, Renee/AAB-7351-2020
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NR 34
TC 28
Z9 39
U1 2
U2 13
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0094-5145
EI 1573-3610
J9 J COMMUN HEALTH
JI J. Community Health
PD DEC
PY 2007
VL 32
IS 6
BP 401
EP 412
DI 10.1007/s10900-007-9059-3
PG 12
WC Health Policy & Services; Public, Environmental & Occupational Health
WE Social Science Citation Index (SSCI)
SC Health Care Sciences & Services; Public, Environmental & Occupational
   Health
GA 221DB
UT WOS:000250206500003
PM 17940871
DA 2025-06-11
ER

PT J
AU Maejima, Y
   Horita, S
   Yokota, S
   Ono, T
   Proks, P
   Yoshida-Komiya, H
   Ueta, Y
   Nishimori, K
   Misaka, S
   Shimomura, K
AF Maejima, Yuko
   Horita, Shoichiro
   Yokota, Shoko
   Ono, Tomoyuki
   Proks, Peter
   Yoshida-Komiya, Hiromi
   Ueta, Yoichi
   Nishimori, Katsuhiko
   Misaka, Shingen
   Shimomura, Kenju
TI Identification of oxytocin receptor activating chemical components from
   traditional Japanese medicines
SO JOURNAL OF FOOD AND DRUG ANALYSIS
LA English
DT Article
DE Kamikihito; Oxytocin neuron; Oxytocin receptor; Traditional Japanese
   medicine
ID IN-VITRO AUTORADIOGRAPHY; HYPOTHALAMIC PARAVENTRICULAR NUCLEUS; CHINESE
   MEDICINE; KAMIKIHI-TO; FOOD-INTAKE; ALZHEIMERS-DISEASE; URSOLIC ACID;
   BRAIN; EXPRESSION; NEURONS
AB Oxytocin (Oxt) is known to regulate social communication, stress and body weight. The activation of Oxt receptors (OTR) has clinical potential to abate stress disorders and metabolic syndrome. Kamikihito (KKT) is a traditional Japanese medicine used to treat psychological stress-related disorders. We investigated the effects of KKT, its ingredients and chemical components on Oxt neurons and OTR. C-Fos expression was examined after oral and peripheral administration of KKT in rats. Electrophysiological change of Oxt neurons and Oxt release upon application of KKT were measured in rat brain slice. The direct effect of KKT, its ingredients and its chemical components were examined by cytosolic Ca2+ ([Ca2+](i)) measurement in Oxt neurons and OTR-expressing HEK293 cells. Both intraperitoneal and oral administration of KKT in rats induced c-Fos expression in neurons of the paraventricular nucleus (PVN) including Oxt neurons. Application of KKT induced activation of Oxt neurons and Oxt release. KKT increased [Ca2+](i) in OTRexpressing HEK293 cells, and failed to activate with OTR antagonist. KKT-induced PVN Oxt neuron activation was also attenuated by OTR antagonist. Seven chemical components (rutin, ursolic acid, (Z)-butylidenephtalide, p-cymene, senkunolide, [6]-shogaol, [8]-shogaol) of three ingredients (Zizyphi Fructus, Angelicae Acutilobae Radix, Zingiberis Rhizoma) from KKT had potential to activate OTR. KKT can directly activate PVN Oxt neurons by interacting with OTR. The interaction of seven chemical components from KKT may contribute to activate OTR. Effect of KKT on Oxt neurons and OTR may contribute to the treatment of Oxt related disorders.
C1 [Maejima, Yuko; Horita, Shoichiro; Yokota, Shoko; Ono, Tomoyuki; Nishimori, Katsuhiko; Misaka, Shingen; Shimomura, Kenju] Fukushima Med Univ, Sch Med, Dept Bioregulat & Pharmacol Med, Fukushima 9601295, Japan.
   [Proks, Peter] Univ Oxford, Oxford Ctr Gene Funct, Oxford OX1 3PT, England.
   [Yoshida-Komiya, Hiromi] Fukushima Med Univ, Sch Med, Gender Specif Med Ctr, Fukushima 9601295, Japan.
   [Ueta, Yoichi] Univ Occupat & Environm Hlth, Sch Med, Dept Physiol, Kitakyushu, Fukuoka 8078555, Japan.
C3 Fukushima Medical University; University of Oxford; Fukushima Medical
   University; University of Occupational & Environmental Health - Japan
RP Maejima, Y; Shimomura, K (corresponding author), Fukushima Med Univ, Sch Med, Dept Bioregulat & Pharmacol Med, Fukushima 9601295, Japan.
EM maejimay@fmu.ac.jp; shimomur@fmu.ac.jp
RI Misaka, Shingen/AFH-6218-2022
FU  [18K08483];  [26461366]
FX The authors appreciate Prof. Kazuto Kobayashi and Dr. Shigeki Kato of
   the Department of Molec-ular Genetics, Institute of Biomedical Sciences,
   Fukushima Medical University for providing the RFP-encoding gene. The
   authors thank Tsumura Co. for kindly providing KKT, the individual crude
   drugs and chemical components included in KKT. The authors appreciate
   Dr. Takeyasu Kakamu of Department of Hygiene and Preventive Medicine
   Fukushima Medical University for providing advice of statistical
   analysis. This work was supported by a Grant-in-Aid for Scientific
   Research (C) (18K08483 to Y. M, 26461366 to K. S) .
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NR 75
TC 5
Z9 5
U1 0
U2 9
PU DIGITAL COMMONS BEPRESS
PI BERKELEY
PA 2100 MILVIA ST, STE 300, BERKELEY, CA 94704 USA
SN 1021-9498
J9 J FOOD DRUG ANAL
JI J. Food Drug Anal.
PY 2021
VL 29
IS 4
BP 653
EP 675
DI 10.38212/2224-6614.3381
PG 24
WC Food Science & Technology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Pharmacology & Pharmacy
GA XQ6JL
UT WOS:000731652100008
PM 35649140
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Steptoe, A
   Kunz-Ebrecht, SR
   Brydon, L
   Wardle, J
AF Steptoe, A
   Kunz-Ebrecht, SR
   Brydon, L
   Wardle, J
TI Central adiposity and cortisol responses to waking in middle-aged men
   and women
SO INTERNATIONAL JOURNAL OF OBESITY
LA English
DT Article
DE central adiposity; cortisol; waking response; sex differences; stress
ID BODY-FAT DISTRIBUTION; STRESS-INDUCED CORTISOL; PITUITARY-ADRENAL AXIS;
   LOW-BIRTH-WEIGHT; SOCIOECONOMIC-STATUS; SALIVARY CORTISOL; ABDOMINAL
   OBESITY; INSULIN-RESISTANCE; METABOLIC SYNDROME; SECRETION
AB OBJECTIVE: Central obesity is associated with disturbances of hypothalamic-pituitary-adrenocortical (HPA) axis function. We investigated whether central adiposity indexed by waist/hip ratio is related to cortisol responses to waking and other measures of salivary cortisol over the working day.
   PARTICIPANTS: In total, 89 men and 83 women aged 47-59 y recruited from the British civil service. All were members of the Whitehall II epidemiological cohort.
   METHODS: Saliva samples were collected on waking, 30 min later, and then at 2-h intervals from 0800-0830 to 2200-2230. A strict procedure for excluding individuals who did not adhere to the sampling schedule was applied.
   RESULTS: Waist/hip ratio in men was positively correlated with the cortisol response to waking (30 min-waking value) after adjusting for age, socioeconomic position, smoking status, alcohol consumption, time of waking, and cortisol level on waking (r = 0.29, P = 0.009). The cortisol response to waking was negatively related to high-density lipoprotein (HDL) cholesterol (r = -0.25) and positively with total/HDL cholesterol ratio (r = 0.25). Associations between the decline in cortisol over the day and waist/hip ratio, HDL cholesterol and total/HDL cholesterol ratios were also significant. No associations were significant in women, and body mass index was unrelated to cortisol.
   CONCLUSIONS: The cortisol response to waking is a dynamic indicator of HPA function that has previously been related to chronic psychological stress. These results confirm a recent Swedish study, and indicate that cortisol responses to waking may be indicative of neuroendocrine disturbance in central obesity.
C1 UCL, Dept Epidemiol & Publ Hlth, London WC1E 6BT, England.
C3 University of London; University College London
RP UCL, Dept Epidemiol & Publ Hlth, 1-19 Torrington Pl, London WC1E 6BT, England.
EM a.steptoe@ucl.ac.uk
RI Steptoe, Andrew/Y-2440-2019
OI Steptoe, Andrew/0000-0001-7808-4943
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NR 44
TC 86
Z9 98
U1 0
U2 7
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0307-0565
EI 1476-5497
J9 INT J OBESITY
JI Int. J. Obes.
PD SEP
PY 2004
VL 28
IS 9
BP 1168
EP 1173
DI 10.1038/sj.ijo.0802715
PG 6
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 846QQ
UT WOS:000223331200011
PM 15211363
DA 2025-06-11
ER

PT J
AU Jung, DS
   Son, YJ
   Shin, JM
   Won, HJ
   Le, TT
   Jung, SH
   Lee, CH
   Nho, CW
AF Jung, Da Seul
   Son, Yang-Ju
   Shin, Ji Min
   Won, Hyo Jun
   Le, Tam Thi
   Jung, Sang Hoon
   Lee, Chang-Ho
   Nho, Chu Won
TI Gymnaster KoraiensisExtract Alleviated Metabolic Syndrome
   Symptoms and Stimulated UCP1-Independent Energy Consumption via AMPK
   Activation in White Adipose Tissue
SO MOLECULAR NUTRITION & FOOD RESEARCH
LA English
DT Article
DE AMP-activated protein kinase; Gymnaster koraiensis; metabolic syndrome;
   obesity; UCP1-independent energy consumption
ID INSULIN-RESISTANCE; PPAR-GAMMA; OBESITY; FAT; POLYACETYLENE; MANAGEMENT;
   PROTEIN; ACID
AB Scope Metabolic syndrome and obesity are rising worldwide concerns that are accompanied by adverse health consequences. Here, it is hypothesized that the ethanol extract fromGymnaster koraiensis(GK), an edible Korean plant known for its anti-cancer and hepatoprotective properties, could attenuate metabolic syndrome-related symptoms in high-fat dietary-induced obese (DIO) mice. Methods and Results Administration of 100 mg kg(-1)GK extract to DIO mice effectively reduces body and white adipose tissue (WAT) weight. It also reduces cardiovascular disease risk and improves insulin resistance by lowering the fasting blood glucose levels and mitigating oxidative stress and inflammation. Moreover, supplementation with GK causes elevated energy expenditure in WAT by increasing the mitochondrial oxidative capacity and lipid catabolism through upregulated adenosine monophosphate-activated protein kinase (AMPK) signaling. Orlistat is used as a positive control drug due to its widespread use in previous studies. It is found that GK extract causes weight loss, similar to Orlistat, and it additionally shows unique functions, such as upregulation of energy consumption in WAT. Conclusion GK extract treatment prominently reduces obesity and its associated metabolic complications, such as hyperlipidemia, hyperglycemia, and insulin resistance. Hence, It can be used as a promising multi-target functional food that can improve metabolic syndrome-related symptoms.
C1 [Jung, Da Seul; Son, Yang-Ju; Shin, Ji Min; Won, Hyo Jun; Nho, Chu Won] Korea Inst Sci & Technol KIST, Smart Farm Res Ctr, Kangnung 25451, Gangwon Do, South Korea.
   [Jung, Da Seul; Lee, Chang-Ho] Gangneung Wonju Natl Univ, Coll Nat Sci, Dept Biol, Kangnung 25457, Gangwon Do, South Korea.
   [Shin, Ji Min; Won, Hyo Jun; Le, Tam Thi; Jung, Sang Hoon; Nho, Chu Won] Korea Univ Sci & Technol UST, KIST Sch, Div Biomed Sci & Technol, Daejeon 34113, South Korea.
   [Le, Tam Thi; Jung, Sang Hoon] Korea Inst Sci & Technol KIST, Nat Prod Res Ctr, Kangnung 25451, Gangwon Do, South Korea.
C3 Korea Institute of Science & Technology (KIST); Gangneung-Wonju National
   University; Korea Institute of Science & Technology (KIST); University
   of Science & Technology (UST); Korea Institute of Science & Technology
   (KIST)
RP Nho, CW (corresponding author), Korea Inst Sci & Technol KIST, Smart Farm Res Ctr, Kangnung 25451, Gangwon Do, South Korea.; Nho, CW (corresponding author), Korea Univ Sci & Technol UST, KIST Sch, Div Biomed Sci & Technol, Daejeon 34113, South Korea.
EM cwnho@kist.re.kr
RI Le, Tam/LMN-0473-2024
OI Son, Yang-Ju/0000-0002-7562-1915; JUNG, DASEUL/0000-0001-5695-2578
FU Korea-Mongolia Cooperation Project from the National Research Foundation
   of Korea (NRF) [2008-00592]; Korea Institute of Science and Technology,
   Gangneung Institute [2Z05630]; Swedish Research Council [2008-00592]
   Funding Source: Swedish Research Council
FX This study was supported by the Korea-Mongolia Cooperation Project from
   the National Research Foundation of Korea (NRF) (grant number
   2008-00592). Also, this work was supported by an intramural grant from
   the Korea Institute of Science and Technology, Gangneung Institute
   (grant number 2Z05630).
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NR 49
TC 4
Z9 4
U1 2
U2 21
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1613-4125
EI 1613-4133
J9 MOL NUTR FOOD RES
JI Mol. Nutr. Food Res.
PD NOV
PY 2020
VL 64
IS 22
AR 2000490
DI 10.1002/mnfr.202000490
EA OCT 2020
PG 9
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA PA5EG
UT WOS:000579461200001
PM 33022138
DA 2025-06-11
ER

PT J
AU Ozcan, L
   Polat, EC
   Kocaaslan, R
   Onen, E
   Otunctemur, A
   Ozbek, E
AF Ozcan, L.
   Polat, E. C.
   Kocaaslan, R.
   Onen, E.
   Otunctemur, A.
   Ozbek, E.
TI Effects of taking tadalafil 5 mg once daily on erectile function and
   total testosterone levels in patients with metabolic syndrome
SO ANDROLOGIA
LA English
DT Article
DE erectile dysfunction; tadalafil; testosterone
ID INDUCED OXIDATIVE STRESS; GENE-EXPRESSION; ESTROGEN-RECEPTOR; LEAD
   ACETATE; NITRIC-OXIDE; SPERMATOGENESIS; AROMATASE; OXYGEN;
   CYTOCHROME-P450; REPRODUCTION
AB We aimed to evaluate the efficacy of tadalafil 5 mg once-daily treatment on testosterone levels in patients with erectile dysfunction (ED) accompanied by the metabolic syndrome. A total of 40 men with metabolic syndrome were evaluated for ED in this study. All the patients received 5 mg tadalafil once a day for 3 months. Erectile function was assessed using the five-item version of the International Index of Erectile Function (IIEF) questionnaire. Serum testosterone, follicle-stimulating hormone and luteinising hormone levels were also evaluated, and blood samples were taken between 08.00 and 10.00 in the fasting state. All participants have three or more criteria of metabolic syndrome. At the end of 3 months, mean testosterone values and IIEF scores showed an improvement from baseline values (from 3.6 +/- 0.5 to 5.2 +/- 0.3, from 11.3 +/- 1.9 to 19 +/- 0.8 respectively). After the treatment, serum LH levels were decreased (from 5.6 +/- 0.6 to 4.6 +/- 0.5). There was significantly difference in terms of baseline testosterone and luteinising hormone values and IIEF scores (p < .05). Based on our findings, we recommend tadalafil 5 mg once daily in those men with erectile dysfunction especially low testosterone levels accompanied by metabolic syndrome. +/-
C1 [Ozcan, L.; Onen, E.] Derince Training & Res Hosp, Dept Urol, Kocaeli, Turkey.
   [Polat, E. C.; Otunctemur, A.; Ozbek, E.] Okmeydani Training & Res Hosp, Dept Urol, Istanbul, Turkey.
   [Kocaaslan, R.] Kafkas Univ, Med Fac, Dept Urol, Kars, Turkey.
C3 Kocaeli Derince Training & Research Hospital; Istanbul Okmeydani
   Training & Research Hospital; Kafkas University
RP Ozcan, L (corresponding author), Derince Training & Res Hosp, Dept Urol, Kocaeli, Turkey.
EM drleventozcan@yahoo.com
RI Ozcan, Levent/AAV-8512-2021; Polat, Emre/ABI-4703-2020; Kocaaslan,
   Ramazan/HII-6970-2022
OI Polat, Emre Can/0000-0001-5254-2563; Otunctemur,
   Alper/0000-0002-0553-3012
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NR 47
TC 13
Z9 13
U1 0
U2 8
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0303-4569
EI 1439-0272
J9 ANDROLOGIA
JI Andrologia
PD NOV
PY 2017
VL 49
IS 9
AR e12751
DI 10.1111/and.12751
PG 5
WC Andrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA FJ6BI
UT WOS:000412838200010
PM 28295481
DA 2025-06-11
ER

PT J
AU Contoreggi, C
   Rice, KC
   Chrousos, G
AF Contoreggi, C
   Rice, KC
   Chrousos, G
TI Nonpeptide corticotropin-releasing hormone receptor type 1 antagonists
   and their applications in psychosomatic disorders
SO NEUROENDOCRINOLOGY
LA English
DT Review
DE stress; corticotropin-releasing hormone; corticotropin-releasing hormone
   receptors; hypothalamic-pituitary-adrenal axis; autoimmune diseases;
   Cushing's syndrome; Nelson's syndrome; inflammation; psychosomatic
   disorders; neuroimmune interactions
ID PITUITARY-ADRENAL AXIS; DIAGNOSED RHEUMATOID-ARTHRITIS;
   IRRITABLE-BOWEL-SYNDROME; HYPOTHALAMIC-PITUITARY; ABDOMINAL OBESITY;
   CUSHINGS-SYNDROME; CORTISOL SECRETION; INSULIN-RESISTANCE; FACTOR CRF;
   GLUCOCORTICOID-RECEPTOR
AB Overproduction of corticotropin-releasing hormone (CRH) and stress system abnormalities are seen in psychiatric diseases such as depression, anxiety, eating disorders, and addiction. Investigations of CRH type 1 receptor (CRHR1) nonpeptide antagonists suggest therapeutic potential for treatment of these and other neuropsychiatric diseases. However, overproduction of CRH in the brain and on its periphery and disruption of the hypothalamic-pituitary-adrenal axis are also found in 'somatic' disorders. Some rare forms of Cushing's disease and related pituitary/adrenal disorders are obvious applications for CRHR1 antagonists. In addition, however, these antagonists may also be effective in treating more common somatic diseases. Patients with obesity and metabolic syndrome who often have subtle, but chronic hypothalamic-pituitary-adrenal hyperactivity, which may reflect central dysregulation of CRH and consequently glucocorticoid hypersecretion, could possibly be treated by administration of CRHR1 antagonists. Hormonal, autonomic, and immune aberrations are also present in chronic inflammatory, autoimmune, and allergic diseases, with considerable evidence linking CRH with the observed abnormalities. Furthermore, autonomic dysregulation is a prominent feature of common gastrointestinal disorders, such as irritable bowel syndrome and peptic ulcer disease. Patients with irritable bowel syndrome and other gastrointestinal disorders frequently develop altered pain perception and affective symptoms. CRH acts peripherally to modulate bowel activity both directly through the autonomic system and centrally by processing viscerosensory and visceromotor neural signals. This review presents clinical and preclinical evidence for the role of CRH in the pathophysiology of these disorders and for potential diagnostic and therapeutic applications of CRHR1 antagonists. Recognition of a dysfunctional stress system in these and other diseases will alter the understanding and treatment of 'psychosomatic' disorders. Copyright (C) 2004 S. Karger AG, Basel.
C1 NIDA, Intramural Res Program, Baltimore, MD 21224 USA.
   NIDDKD, Intramural Res Program, Bethesda, MD 20892 USA.
   NICHHD, Intramural Res Program, Bethesda, MD 20892 USA.
   NIH, US Dept HHS, Bethesda, MD 20892 USA.
C3 National Institutes of Health (NIH) - USA; NIH National Institute on
   Drug Abuse (NIDA); National Institutes of Health (NIH) - USA; NIH
   National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK);
   National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver
   National Institute of Child Health & Human Development (NICHD); National
   Institutes of Health (NIH) - USA
RP NIDA, Intramural Res Program, 5500 Nathan Shock Dr, Baltimore, MD 21224 USA.
EM ccontore@intra.nida.nih.gov
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NR 114
TC 17
Z9 21
U1 0
U2 14
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0028-3835
EI 1423-0194
J9 NEUROENDOCRINOLOGY
JI Neuroendocrinology
PY 2004
VL 80
IS 2
BP 111
EP 123
DI 10.1159/000081785
PG 13
WC Endocrinology & Metabolism; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology
GA 873DD
UT WOS:000225258600005
PM 15523186
DA 2025-06-11
ER

PT J
AU Carter, S
   Hartman, Y
   Holder, S
   Thijssen, DH
   Hopkins, ND
AF Carter, Sophie
   Hartman, Yvonne
   Holder, Sophie
   Thijssen, Dick H.
   Hopkins, Nicola D.
TI Sedentary Behavior and Cardiovascular Disease Risk: Mediating Mechanisms
SO EXERCISE AND SPORT SCIENCES REVIEWS
LA English
DT Review
DE sitting; physical activity; vascular function; shear stress;
   cardiovascular risk factors
ID SIT-STAND WORKSTATIONS; ENDOTHELIAL DYSFUNCTION; PHYSICAL-ACTIVITY;
   SITTING TIME; POSTPRANDIAL GLYCEMIA; CARDIOMETABOLIC RISK; METABOLIC
   RISK; VIEWING TIME; US ADULTS; BREAKING
AB Sedentary behavior has a strong association with cardiovascular disease (CVD) risk, which may be independent of physical activity. To date, the mechanism(s) that mediate this relationship are poorly understood. We hypothesize that sedentary behavior modifies key hemodynamic, inflammatory, and metabolic processes resulting in impaired arterial health. Subsequently, these vascular impairments directly and indirectly contribute to the development of CVD.
C1 [Carter, Sophie; Holder, Sophie; Thijssen, Dick H.; Hopkins, Nicola D.] Liverpool John Moores Univ, Res Inst Sport & Exercise Sci, Byrom St, Liverpool L3 2ET, Merseyside, England.
   [Hartman, Yvonne; Thijssen, Dick H.] Radboud Univ Nijmegen, Med Ctr, Dept Physiol, Nijmegen, Netherlands.
C3 Liverpool John Moores University; Radboud University Nijmegen
RP Hopkins, ND (corresponding author), Liverpool John Moores Univ, Res Inst Sport & Exercise Sci, Byrom St, Liverpool L3 2ET, Merseyside, England.
EM n.d.hopkins@ljmu.ac.uk
RI Thijssen, Dick/E-8731-2016; Hartman, Yvonne/P-2801-2016
OI Carter, Sophie/0000-0003-2815-7360
CR Alkhajah TA, 2012, AM J PREV MED, V43, P298, DOI 10.1016/j.amepre.2012.05.027
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NR 40
TC 182
Z9 207
U1 2
U2 52
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0091-6331
EI 1538-3008
J9 EXERC SPORT SCI REV
JI Exerc. Sport Sci. Rev.
PD APR
PY 2017
VL 45
IS 2
BP 80
EP 86
DI 10.1249/JES.0000000000000106
PG 7
WC Physiology; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology; Sport Sciences
GA EP8KK
UT WOS:000397624100005
PM 28118158
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Markus, E
   Trestman, S
   Cohen, Y
   Angel, Y
   Sofer, Y
   Mittelman, M
   Avivi, I
   Stern, N
   Izkhakov, E
AF Markus, Efrat
   Trestman, Svetlana
   Cohen, Yael
   Angel, Yoel
   Sofer, Yael
   Mittelman, Moshe
   Avivi, Irit
   Stern, Naftali
   Izkhakov, Elena
TI Components of metabolic syndrome in patients with multiple myeloma and
   smoldering multiple myeloma
SO BMC CANCER
LA English
DT Article
DE Smoldering multiple myeloma; Hyperlipidemia; Metabolic changes
ID C-REACTIVE PROTEIN; ACUTE-PHASE PROTEINS; INDEPENDENT RISK-FACTOR;
   DIABETES-MELLITUS; PERIPHERAL NEUROPATHY; ATHEROSCLEROSIS RISK;
   LONG-TERM; INTERLEUKIN-6; TYPE-2; CANCER
AB Background The prevalences of diabetes mellitus and hypertension, both of which are components of metabolic syndrome, are known to be increased among patients with multiple myeloma (MM), but remain undetermined among patients with smoldering MM (SMM). Methods Changes in various components of metabolic syndrome were investigated during the follow-up of patients with either MM or SMM compared to healthy controls. The data of 153 patients (105 with MM and 48 with SMM) and 138 controls were accessed from our medical center's records between 2008 and 2015. We analyzed the patients' data at diagnosis (baseline) and after 1, 3, and 5 years of follow-up. Results Patients with SMM had a significantly higher prevalence of diabetes, hypertension, and dyslipidemia at baseline compared to controls. A multivariate Cox regression analysis revealed a higher risk to develop dyslipidemia after 1, 3, and 5 years of follow-up among the SMM patients. The MM patients had a higher risk to develop diabetes after 1 year, hypertension after 5 years, and dyslipidemia after 1, 3, and 5 years of follow-up. Conclusions These data demonstrate that patients with SMM and those with MM are more prone to develop various components of metabolic syndrome, and they stress the importance of following-up metabolic syndrome components in both groups of patients.
C1 [Markus, Efrat; Sofer, Yael; Stern, Naftali; Izkhakov, Elena] Tel Aviv Sourasky Med Ctr, Inst Endocrinol Metab & Hypertens, Tel Aviv, Israel.
   [Markus, Efrat; Trestman, Svetlana; Cohen, Yael; Angel, Yoel; Sofer, Yael; Mittelman, Moshe; Avivi, Irit; Stern, Naftali; Izkhakov, Elena] Tel Aviv Univ, Sackler Fac Med, Tel Aviv, Israel.
   [Trestman, Svetlana; Cohen, Yael; Avivi, Irit] Tel Aviv Sourasky Med Ctr, Inst Hematol, Tel Aviv, Israel.
   [Angel, Yoel] Tel Aviv Sourasky Med Ctr, Dept Internal Med C, Tel Aviv, Israel.
   [Mittelman, Moshe] Tel Aviv Sourasky Med Ctr, Dept Internal Med A, Tel Aviv, Israel.
C3 Tel Aviv University; Sackler Faculty of Medicine; Tel Aviv Sourasky
   Medical Center; Tel Aviv University; Sackler Faculty of Medicine; Tel
   Aviv University; Sackler Faculty of Medicine; Tel Aviv Sourasky Medical
   Center; Tel Aviv University; Sackler Faculty of Medicine; Tel Aviv
   Sourasky Medical Center; Tel Aviv University; Sackler Faculty of
   Medicine; Tel Aviv Sourasky Medical Center
RP Izkhakov, E (corresponding author), Tel Aviv Sourasky Med Ctr, Inst Endocrinol Metab & Hypertens, Tel Aviv, Israel.; Izkhakov, E (corresponding author), Tel Aviv Univ, Sackler Fac Med, Tel Aviv, Israel.
EM elenaiz@tlvmc.gov.il
OI Avivi, Irit/0000-0001-8663-444X; Markus, Efrat/0009-0002-5643-445X;
   Angel, Yoel/0000-0002-2243-6601
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NR 48
TC 8
Z9 12
U1 0
U2 4
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2407
J9 BMC CANCER
JI BMC Cancer
PD MAY 30
PY 2020
VL 20
IS 1
AR 489
DI 10.1186/s12885-020-06976-1
PG 8
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA LU9GS
UT WOS:000538055700002
PM 32473631
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Lee, BG
   Lee, H
AF Lee, Bo Gyeong
   Lee, Haein
TI Health-related quality of life associated with coexisting chronic
   conditions in postmenopausal women
SO HEALTH CARE FOR WOMEN INTERNATIONAL
LA English
DT Article
ID METABOLIC SYNDROME; POPULATION; DEPRESSION; PREVALENCE; DURATION
AB We aimed to examine the association between metabolic syndrome (MetS), depressive symptoms, and health-related quality of life in postmenopausal women. We conducted a descriptive cross-sectional study in naturally postmenopausal women aged 45-65 years using data from the 8th Korea National Health and Nutrition Examination Survey. We classified the participants into four groups: normal (neither MetS nor depressive symptoms), MetS, depressive symptoms, and MetS + depressive symptoms. Compared to the other three groups, the MetS + depressive symptoms group had the worst self-rated health. High fasting glucose, high triglyceride and low high-density lipoprotein-cholesterol levels were the most common in the MetS + depressive symptoms group. After adjusting for covariates, the MetS + depressive symptoms group was more likely to have problems with usual activities and pain/discomfort than the normal group.
C1 [Lee, Bo Gyeong; Lee, Haein] Daegu Catholic Univ, Res Inst Nursing Sci, Coll Nursing, 33 Duryugongwon Ro 17 Gil, Daegu 42472, South Korea.
C3 Catholic University of Daegu
RP Lee, H (corresponding author), Daegu Catholic Univ, Res Inst Nursing Sci, Coll Nursing, 33 Duryugongwon Ro 17 Gil, Daegu 42472, South Korea.
EM hlee1317@cu.ac.kr
RI Lee, Bo Gyeong/AFR-5483-2022
OI Lee, Haein/0000-0003-1918-4148; Lee, Bo Gyeong/0000-0003-1308-1287
FU Daegu Catholic University [20211072]
FX This work was supported by research grants from Daegu Catholic
   University in 2021 (No. 20211072).
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NR 35
TC 0
Z9 0
U1 1
U2 1
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 0739-9332
EI 1096-4665
J9 HEALTH CARE WOMEN IN
JI Health Care Women Int.
PD NOV 1
PY 2024
VL 45
IS 11
BP 1220
EP 1234
DI 10.1080/07399332.2023.2197846
EA MAR 2023
PG 15
WC Public, Environmental & Occupational Health; Women's Studies
WE Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; Women's Studies
GA K5U4E
UT WOS:000972439200001
PM 37058115
DA 2025-06-11
ER

PT J
AU Happell, B
   Scott, D
   Nankivell, J
   Platania-Phung, C
AF Happell, Brenda
   Scott, David
   Nankivell, Janette
   Platania-Phung, Chris
TI Screening physical health? Yes! But...: nurses' views on physical health
   screening in mental health care
SO JOURNAL OF CLINICAL NURSING
LA English
DT Article
DE monitoring; nurses; physical health; risk management; screening; side
   effects
ID METABOLIC SYNDROME; ANTIPSYCHOTIC-DRUGS; HEART-DISEASE; MEDICAL-CARE;
   RISK-FACTORS; PEOPLE; SCHIZOPHRENIA; ILLNESS; GUIDELINES; QUALITY
AB Aims and objectives To explore nurses' views on the role of nurses in screening and monitoring for physical care of consumers with serious mental illness, at a regional mental health care service.
   Background People with serious mental illness experience heightened incidence of preventable and treatable physical illnesses such as cardiovascular disease and diabetes. Screening and monitoring are considered universal clinical safeguards. Nurses can potentially facilitate systematic screening, but their views on physical health care practices are rarely investigated.
   Design Qualitative exploratory study.
   Method Focus group interviews with 38 nurses of a regional mental health care service district of Australia. To facilitate discussion, participants were presented with a screening system, called the Health Improvement Profile (HIP), as an exemplar of screening of physical health risks by nurses. Inductive data analysis and theme development were guided by a thematic analysis framework.
   Results Nurses argued that treatable and preventable physical health problems were common. Four main themes were identified: screening - essential for good practice; the policy-practice gap; screening then what?' and, is HIP the answer? Screening and monitoring were considered crucial to proper diagnosis and treatment, however, were not performed systematically or consistently. Nurse readiness for an enhanced role in screening was shaped by: role and responsibility issues, legal liability concerns, funding and staff shortages. Participants were concerned that lack of follow up would limit effectiveness of these interventions.
   Conclusions Screening was considered an important clinical step in effective diagnosis and treatment; however, identified barriers need to be addressed to ensure screening is part of a systemic approach to improve physical health of consumers with serious mental illness.
   Relevance to clinical practiceNurses have potential to influence improvement in physical health outcomes for consumers of mental health services. Such potential can only be realised if a systematic approach to physical health care is taken.
C1 [Happell, Brenda; Scott, David; Nankivell, Janette; Platania-Phung, Chris] Cent Queensland Univ, Sch Nursing & Midwifery, Inst Hlth & Social Sci Res, Rockhampton, Qld 4702, Australia.
C3 Central Queensland University
RP Happell, B (corresponding author), Sch Nursing & Midwifery, Inst Hlth & Social Sci Res, Rockhampton, Qld 4702, Australia.
EM b.happell@cqu.edu.au
RI Scott, David/AAE-5031-2021; Happell, Brenda/HSI-0570-2023
OI Scott, David/0000-0001-5226-1972; Happell, Brenda/0000-0002-7293-6583
FU Merit Grant Scheme of CQUniversity
FX The authors would like to thank nurses of the Central Queensland Health
   Service District Mental Health Service for their participation. We also
   would like to thank Wendy Hoey for her support in organising study
   participants and facilities and Zara Mills for facilitating the focus
   groups. Financial support for this research was provided by The Merit
   Grant Scheme of CQUniversity.
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NR 66
TC 52
Z9 53
U1 0
U2 28
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0962-1067
EI 1365-2702
J9 J CLIN NURS
JI J. Clin. Nurs.
PD AUG
PY 2013
VL 22
IS 15-16
BP 2286
EP 2297
DI 10.1111/j.1365-2702.2012.04325.x
PG 12
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA 176UU
UT WOS:000321332100021
PM 23829406
DA 2025-06-11
ER

PT J
AU Singh, C
   Jain, S
   Dhawan, V
   Kalra, N
   Kumari, S
AF Singh, Charanpreet
   Jain, Sanjay
   Dhawan, Veena
   Kalra, Naveen
   Kumari, Savita
TI Uric acid as a predictor of endothelial dysfunction in patients with
   metabolic syndrome
SO ARCHIVES OF ENDOCRINOLOGY METABOLISM
LA English
DT Article
DE Uric acid; metabolic syndrome; endothelial dysfunction
ID INSULIN-RESISTANCE; HYPERURICEMIA; ADULTS; RISK
AB Objective: We conducted a study to examine the association of endothelial dysfunction and oxidative stress with uric acid levels in patients of metabolic syndrome. Subjects and methods: One hundred and two patients of Metabolic Syndrome (International Diabetes Federation definition) were included in the study. Anthropometric measurements, serum uric acid levels, fasting blood sugar levels and lipid levels, as well as malondialdehyde and reactive nitrogen intermediates were measured after an 8-hour fasting period. Flow mediated vasodilation (FMD) of the brachial artery was measured and endothelial dysfunction was defined as an increase in diameter < 10% post compression. Results: A total of 102 patients were included in the study. Mean uric acid level was 5.49 +/- 1.61 mg%. A total of 59 patients in the study had endothelial dysfunction, defined by an abnormal FMD. Patients with an abnormal FMD had higher levels of serum uric acid which was statistically significant (p value = 0.010). Serum RNI and MDA levels were negatively correlated with uric acid, but did not reach statistical significance. Patients with an abnormal FMD had a lower RNI level, but this did not reach statistical significance. Serum MDA levels were significantly higher in patients with an abnormal FMD (p value = 0.038). Conclusions: Uric acid was significantly associated with endothelial dysfunction in patients with metabolic syndrome in our study. It was inversely correlated with serum RNI and MDA levels, but this did not reach statistical significance.
C1 [Singh, Charanpreet; Jain, Sanjay; Kumari, Savita] Post Grad Inst Med Educ & Res, Dept Internal Med, Chandigarh, India.
   [Dhawan, Veena] Post Grad Inst Med Educ & Res, Dept Expt Med, Chandigarh, India.
   [Kalra, Naveen] Post Grad Inst Med Educ & Res, Dept Radiodiag, Chandigarh, India.
C3 Post Graduate Institute of Medical Education & Research (PGIMER),
   Chandigarh; Post Graduate Institute of Medical Education & Research
   (PGIMER), Chandigarh; Post Graduate Institute of Medical Education &
   Research (PGIMER), Chandigarh
RP Singh, C (corresponding author), Post Grad Inst Med Educ & Res PGIMER, Dept Internal Med, Chandigarh 160012, India.
EM charanpreetsingh14@gmail.com
OI Dhawan, Veena/0000-0001-9464-1033
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NR 22
TC 12
Z9 12
U1 0
U2 8
PU SBEM-SOC BRASIL ENDOCRINOLOGIA & METABOLOGIA
PI RIO DE JANEIRO, RJ
PA RUA HUMAITA, 85 CJ 501, RIO DE JANEIRO, RJ, 22261-000, BRAZIL
SN 2359-3997
EI 2359-4292
J9 ARCH ENDOCRIN METAB
JI Arch. Endocrinol. Metab.
PD NOV-DEC
PY 2020
VL 64
IS 6
BP 810
EP 815
DI 10.20945/2359-3997000000298
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA PD0UN
UT WOS:000597410200023
PM 33085991
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Jepsen, S
   Suvan, J
   Deschner, J
AF Jepsen, Soren
   Suvan, Jean
   Deschner, James
TI The association of periodontal diseases with metabolic syndrome and
   obesity
SO PERIODONTOLOGY 2000
LA English
DT Review
DE cardiovascular disease; dyslipidemia; dysglycemia; hypertension;
   metabolic syndrome; obesity; periodontitis
ID BODY-MASS INDEX; JOINT EFP/ORCA WORKSHOP; NECROSIS-FACTOR-ALPHA; BETA-3
   ADRENERGIC-RECEPTOR; IMMUNE-MECHANISMS RELEVANT; SUGAR-SWEETENED
   BEVERAGES; TYPE-2 DIABETES-MELLITUS; INSULIN-RESISTANCE; OXIDATIVE
   STRESS; CONSENSUS REPORT
AB Periodontitis is a multifactorial chronic inflammatory disease associated with dysbiotic plaque biofilms and characterized by progressive destruction of the tooth-supporting apparatus. Globally, it is estimated that 740 million people are affected by its severe form. Periodontitis has been suggested to be linked to obesity and metabolic syndrome. Obesity, defined as excessive fat accumulation, is a complex multifactorial chronic inflammatory disease, with a high and increasing prevalence. Metabolic syndrome is defined as a cluster of obesity, dyslipidemia, hypertension, and dysglycemia. Obesity, metabolic syndrome and periodontitis are among the most common non-communicable diseases and a large body of evidence from epidemiologic studies supports the association between these conditions. Extensive research has established plausible mechanisms to explain how these conditions can negatively impact each other, pointing to a bidirectional adverse relationship. At present there is only limited evidence available from a few intervention studies. Nevertheless, the global burden of periodontitis combined with the obesity epidemic has important clinical and public health implications for the dental team. In accordance with the common risk factor approach for tackling non-communicable diseases, it has been proposed that oral healthcare professionals have an important role in the promotion of periodontal health and general well-being through facilitation of healthy lifestyle behaviours.
C1 [Jepsen, Soren] Univ Bonn, Dept Periodontol Operat & Prevent Dent, Bonn, Germany.
   [Suvan, Jean] UCL Eastman Dent Inst, Dept Periodontol, London, England.
   [Deschner, James] Johannes Gutenberg Univ Mainz, Dept Periodontol & Operat Dent, Mainz, Germany.
C3 University of Bonn; University of London; University College London;
   Johannes Gutenberg University of Mainz
RP Jepsen, S (corresponding author), Univ Bonn, Dept Periodontol Operat & Prevent Dent, Ctr Oral Maxillofacial Med, Welschnonnenstr 17, Bonn 53111, Germany.
EM sjepsen@uni-bonn.de
RI DESCHNER, JAMES/AAW-3998-2021; Jepsen, Søren/AAG-9619-2019
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NR 231
TC 194
Z9 198
U1 15
U2 83
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0906-6713
EI 1600-0757
J9 PERIODONTOL 2000
JI Periodontol. 2000
PD JUN
PY 2020
VL 83
IS 1
BP 125
EP 153
DI 10.1111/prd.12326
PG 29
WC Dentistry, Oral Surgery & Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dentistry, Oral Surgery & Medicine
GA LK7KD
UT WOS:000531040100010
PM 32385882
OA Green Published
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Mozos, I
   Luca, CT
AF Mozos, Ioana
   Luca, Constantin Tudor
TI Crosstalk between Oxidative and Nitrosative Stress and Arterial
   Stiffness
SO CURRENT VASCULAR PHARMACOLOGY
LA English
DT Review
DE Arterial stiffness; reactive nitrogen species; reactive oxygen species;
   nitrosative stress; oxidative stress
ID VITAMIN-E SUPPLEMENTATION; INTIMA-MEDIA THICKNESS;
   SYSTEMIC-LUPUS-ERYTHEMATOSUS; NITRIC-OXIDE SYNTHASE; ANKLE VASCULAR
   INDEX; PULSE-WAVE VELOCITY; ENDOTHELIAL FUNCTION; ANTIOXIDANT STATUS;
   METABOLIC SYNDROME; KAWASAKI-DISEASE
AB Background: Arterial stiffness, the expression of reduced arterial elasticity, is an effective predictor of cardiovascular disorders. Oxidative stress is an imbalance between exposure to toxic reactive oxygen species (ROS) and antioxidant systems. The increase in reactive nitrogen species (RNS) is termed nitrosative stress.
   Methodology: We review the main mechanisms and products linking arterial stiffness with oxidative and nitrosative stress in several disorders, focusing on recent experimental and clinical data, and the mechanisms explaining benefits of antioxidant therapy. Oxidative and nitrosative stress play important roles in arterial stiffness elevation in several disorders, including diabetes mellitus, hypertension, metabolic syndrome, obesity, peripheral arterial disease, chronic obstructive pulmonary disease, systemic lupus erythematosus, thalassemia, Kawasaki disease and malignant disorders. Oxidative and nitrosative stress are responsible for endothelial dysfunction due to uncoupling of the nitric oxide synthase, oxidative damage to lipids, proteins and DNA in vascular endothelial cells, associated with inflammation, arteriosclerosis and atherosclerosis.
   Conclusion: Regular physical exercise, caloric restriction, red wine, statins, sartans, metformin, oestradiol, curcumin and combinations of antioxidant vitamins are therapeutic strategies that may decrease arterial stiffness and oxidative stress thus reducing the risk of cardiovascular events. ROS and RNS represent potential therapeutic targets for preventing progression of arterial stiffness.
C1 [Mozos, Ioana] Victor Babes Univ Med & Pharm, Discipline Pathophysiol, Dept Funct Sci, Timisoara, Romania.
   [Luca, Constantin Tudor] Victor Babes Univ Med & Pharm, Dept Cardiol, Timisoara, Romania.
C3 Victor Babes University of Medicine & Pharmacy, Timisoara; Victor Babes
   University of Medicine & Pharmacy, Timisoara
RP Mozos, I (corresponding author), Victor Babes Univ Med & Pharm, Dept Funct Sci, T Vladimirescu St 14, Timisoara 300173, Romania.
EM ioanamozos@yahoo.de
RI Luca, Constantin/LVS-4258-2024; Mozos, Ioana/AAB-4874-2020
OI Mozos, Ioana/0000-0001-6353-7698
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NR 119
TC 61
Z9 66
U1 1
U2 29
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1570-1611
EI 1875-6212
J9 CURR VASC PHARMACOL
JI Current Vascular Pharmacology
PY 2017
VL 15
IS 5
BP 446
EP 456
DI 10.2174/1570161115666170201115428
PG 11
WC Pharmacology & Pharmacy; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Cardiovascular System & Cardiology
GA FD4BQ
UT WOS:000407476700006
PM 28155616
DA 2025-06-11
ER

PT J
AU Moreira, FP
   Jansen, K
   Cardoso, TDA
   Mondin, TC
   Magalhaes, PVDS
   Kapczinski, F
   Souza, LDDM
   da Silva, RA
   Oses, JP
   Wiener, CD
AF Moreira, Fernanda Pedrotti
   Jansen, Karen
   Cardoso, Taiane de Azevedo
   Mondin, Thaise Campos
   da Silva Magalhaes, Pedro Vieira
   Kapczinski, Flavio
   de Mattos Souza, Luciano Dias
   da Silva, Ricardo Azevedo
   Oses, Jean Pierre
   Wiener, Carolina David
TI Metabolic syndrome in subjects with bipolar disorder and major
   depressive disorder in a current depressive episode: Population-based
   study Metabolic syndrome in current depressive episode
SO JOURNAL OF PSYCHIATRIC RESEARCH
LA English
DT Article
DE Metabolic syndrome; Mood disorders; Major depressive disorder; Bipolar
   disorder
ID UNIPOLAR DEPRESSION; PSYCHOTIC DISORDERS; PREVALENCE; SCHIZOPHRENIA;
   ADULTS; RISK; ABNORMALITIES; METAANALYSIS; ASSOCIATION; NUTRITION
AB Objective: To assess the differences in the prevalence of the metabolic syndrome (MetS) and their components in young adults with bipolar disorder (BD) and major depressive disorder (MDD) in a current depressive episode.
   Methods: This was a cross-sectional study with young adults aged 24-30 years old. Depressive episode (bipolar or unipolar) was assessed using the Mini International Neuropsychiatric Interview - Plus version (MINI Plus). The MetS was assessed using the National Cholesterol Education Program Adult Treatment Panel III (NCEP/ATP III).
   Results: The sample included 972 subjects with a mean age of 25.81 (+/- 2.17) years. Both BD and MDD patients showed higher prevalence of MetS compared to the population sample (BD = 46.9%, MDD = 35.1%, population = 22.1%, p < 0.001). Higher levels of glucose, total cholesterol and LDL cholesterol, Body Mass Index, low levels of HDL cholesterol, and a higher prevalence of abdominal obesity were observed in both BD and MDD individuals with current depressive episode compared to the general population. Moreover, there was a significant difference on BMI values in the case of BD and MDD subjects (p = 0.016).
   Conclusion: Metabolic components were significantly associated with the presence of depressive symptoms, independently of the diagnosis. (C) 2017 Published by Elsevier Ltd.
C1 [Moreira, Fernanda Pedrotti; Jansen, Karen; Cardoso, Taiane de Azevedo; Mondin, Thaise Campos; de Mattos Souza, Luciano Dias; da Silva, Ricardo Azevedo; Oses, Jean Pierre; Wiener, Carolina David] Univ Catolica Pelotas, Translat Sci Brain Disorders, Dept Hlth & Behav, Pelotas, RS, Brazil.
   [Jansen, Karen; da Silva Magalhaes, Pedro Vieira; Kapczinski, Flavio] Univ Fed Rio Grande do Sul, Mol Psychiat, Postgrad Program Psychiat & Behav Sci, Porto Alegre, RS, Brazil.
   [Kapczinski, Flavio] McMaster Univ, Hamilton, ON, Canada.
   [Wiener, Carolina David] Univ Fed Pelotas, Dept Epidemiol, Pelotas, RS, Brazil.
C3 Universidade Catolica de Pelotas; Universidade Federal de Pelotas;
   Universidade Federal do Rio Grande do Sul; McMaster University;
   Universidade Federal de Pelotas
RP Jansen, K (corresponding author), Rua Goncalves Chaves 373,Sala 424C, BR-96015560 Pelotas, RS, Brazil.
EM karen.jansen@pq.cnpq.br
RI Pedrotti Moreira, Fernanda/JRX-8306-2023; Oses, Jean/E-2534-2013;
   Kapczinski, Flavio/D-3175-2013; Magalhaes, Pedro/A-8519-2008; Jansen,
   Karen/O-3128-2015
OI Oses, Jean Pierre/0000-0002-2012-273X; Kapczinski,
   Flavio/0000-0001-8738-856X; Magalhaes, Pedro/0000-0002-5644-6357;
   Jansen, Karen/0000-0003-3494-8070; Pedrotti Moreira,
   Fernanda/0000-0002-3672-7231
FU Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior; Conselho
   Nacional de Desenvolvimento Cientifico e Tecnologico; Fundacao de Amparo
   a Pesquisa do Estado do Rio Grande do Sul
FX We gratefully acknowledge the financial support provided by Coordenacao
   de Aperfeicoamento de Pessoal de Nivel Superior, Conselho Nacional de
   Desenvolvimento Cientifico e Tecnologico and Fundacao de Amparo a
   Pesquisa do Estado do Rio Grande do Sul.
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NR 34
TC 62
Z9 64
U1 0
U2 22
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-3956
EI 1879-1379
J9 J PSYCHIATR RES
JI J. Psychiatr. Res.
PD SEP
PY 2017
VL 92
BP 119
EP 123
DI 10.1016/j.jpsychires.2017.03.025
PG 5
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA EZ4RV
UT WOS:000404701100015
PM 28433948
DA 2025-06-11
ER

PT J
AU Benetos, A
   Bulpitt, CJ
   Petrovic, M
   Ungar, A
   Rosei, EA
   Cherubini, A
   Redon, J
   Grodzicki, T
   Dominiczak, A
   Strandberg, T
   Mancia, G
AF Benetos, Athanase
   Bulpitt, Christopher J.
   Petrovic, Mirko
   Ungar, Andrea
   Rosei, Enrico Agabiti
   Cherubini, Antonio
   Redon, Josep
   Grodzicki, Tomasz
   Dominiczak, Anna
   Strandberg, Timo
   Mancia, Giuseppe
TI An Expert Opinion From the European Society of Hypertension-European
   Union Geriatric Medicine Society Working Group on the Management of
   Hypertension in Very Old, Frail Subjects
SO HYPERTENSION
LA English
DT Article
ID NITRIC-OXIDE SYNTHASE; L-ARGININE TRANSPORT; ANGIOTENSIN-CONVERTING
   ENZYME; OBESITY-INDUCED HYPERTENSION; SYMPATHETIC-NERVE ACTIVITY;
   REDUCES OXIDATIVE STRESS; FAT-FED RABBITS; BLOOD-PRESSURE; ENDOTHELIAL
   DYSFUNCTION; METABOLIC SYNDROME
C1 [Benetos, Athanase] CHU Nancy, Dept Geriatr, Nancy, France.
   [Benetos, Athanase] CHU Nancy, FHU CARTAGE, Nancy, France.
   [Benetos, Athanase] Univ Lorraine, INSERM 1116, Nancy, France.
   [Bulpitt, Christopher J.] Univ London Imperial Coll Sci Technol & Med, Dept Med, London, England.
   [Petrovic, Mirko] Ghent Univ Hosp, Dept Geriatr, Ghent, Belgium.
   [Petrovic, Mirko] Univ Ghent, B-9000 Ghent, Belgium.
   [Ungar, Andrea] Univ Florence, Geriatr Cardiol & Med, Florence, Italy.
   [Ungar, Andrea] Azienda Osped Univ Careggi, Florence, Italy.
   [Rosei, Enrico Agabiti] Univ Brescia, Dept Clin & Expt Sci, Med Clin, Brescia, Italy.
   [Cherubini, Antonio] IRCCS INRCA, Geriatria Accettaz Geriatr Urgenza, Ancona, Italy.
   [Redon, Josep] Univ Valencia, CIBERObn ISCiii, INCLIVA Res Inst, Dept Internal Med,Hosp Clin Valencia, Madrid, Spain.
   [Grodzicki, Tomasz] Jagiellonian Univ, Dept Internal Med & Geriatr, Krakow, Poland.
   [Dominiczak, Anna] Univ Glasgow, Coll Med Vet & Life Sci, Glasgow, Lanark, Scotland.
   [Strandberg, Timo] Univ Helsinki, Helsinki, Finland.
   [Strandberg, Timo] Helsinki Univ Cent Hosp, Geriatr, Helsinki, Finland.
   [Strandberg, Timo] Univ Oulu, Ctr Life Course Hlth Res, Oulu, Finland.
   [Mancia, Giuseppe] Univ Milano Bicocca, Dept Clin Med, Milan, Italy.
C3 CHU de Nancy; CHU de Nancy; Institut National de la Sante et de la
   Recherche Medicale (Inserm); Universite de Lorraine; Imperial College
   London; Ghent University; Ghent University Hospital; Ghent University;
   University of Florence; University of Florence; Azienda Ospedaliero
   Universitaria Careggi; University of Brescia; IRCCS INRCA; CIBER -
   Centro de Investigacion Biomedica en Red; CIBEROBN; University of
   Valencia; Jagiellonian University; University of Glasgow; University of
   Helsinki; University of Helsinki; Helsinki University Central Hospital;
   University of Oulu; University of Milano-Bicocca
RP Benetos, A (corresponding author), Univ Hosp Nancy, Dept Geriatr, F-54511 Vandoeuvre Les Nancy, France.
EM a.benetos@chu-nancy.fr
RI Benetos, Athanase/JJC-4282-2023; , aungar/AAB-3720-2019; Cherubini,
   Antonio/AAL-4632-2020; MANCIA, GIUSEPPE/AGF-9410-2022; Redon,
   Josep/L-5997-2019; Grodzicki, Tomasz/K-4451-2012; Dominiczak,
   Anna/P-9390-2017
OI Ungar, Andrea/0000-0002-8965-4523; strandberg, timo/0000-0001-6299-925X;
   Redon, Josep/0000-0001-8777-6773; Grodzicki, Tomasz/0000-0003-0159-4915;
   Dominiczak, Anna/0000-0003-4913-3608; Cherubini,
   Antonio/0000-0003-0261-9897
FU Novartis; Fukuda; Servier; Menarini International; Recordati
   International; Sanofi Aventis; DOC generici; Abbott; Adamed; Sanofi;
   Amgen; AstraZeneca; Pfizer; Orion; Bayer; Boehringer-Ingelheim;
   Nutricia; Actavis; Covidien; CVRx; Daichi Sankyo; Ferrer; Lilly;
   Medtronic Vascular Inc; Merck Serono; MSD; Recordati; Takeda; Menarini
   Int.
FX The authors of this article declared the following potential conflicts
   of interest related to their activities during the last 24 months: A.
   Benetos received speaker's fees from Novartis and Fukuda. C. Bulpitt
   received grants from Servier. E. Agabiti Rosei has received honoraria
   for lectures or grants for research from the following companies:
   Menarini International, Recordati International, Servier, Novartis,
   Sanofi Aventis, and DOC generici. J. Redon received honoraria for
   participating in the Advisory Board of Menarini, Daiichi-Sankyo, GSK and
   for giving lectures for Menarini, Daiichi-Sankyo, Boehringer-Ingelheim.
   T. Grodzicki has received speaker's or consultation fees from Abbott,
   Adamed, Sanofi, and Servier. T. Strandberg reports personal fees from
   Amgen, AstraZeneca, Pfizer, Orion, Bayer, Boehringer-Ingelheim,
   Nutricia, and Abbott. G. Mancia received speaker's or consultation fees
   from: Actavis, Bayer, Boehringer-Ingelheim, Covidien, CVRx, Daichi
   Sankyo, Ferrer, Lilly, Medtronic Vascular Inc, Menarini Int. Merck
   Serono, MSD, Novartis. Recordati, Sanofi, Servier, and Takeda. The other
   authors report no conflicts.
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NR 72
TC 134
Z9 148
U1 1
U2 16
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0194-911X
EI 1524-4563
J9 HYPERTENSION
JI Hypertension
PD MAY
PY 2016
VL 67
IS 5
BP 820
EP 825
DI 10.1161/HYPERTENSIONAHA.115.07020
PG 6
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA DK2WZ
UT WOS:000374776400058
PM 26975708
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Panchal, SK
   Poudyal, H
   Iyer, A
   Nazer, R
   Alam, MA
   Diwan, V
   Kauter, K
   Sernia, C
   Campbell, F
   Ward, L
   Gobe, G
   Fenning, A
   Brown, L
AF Panchal, Sunil K.
   Poudyal, Hemant
   Iyer, Abishek
   Nazer, Reeza
   Alam, Md. Ashraful
   Diwan, Vishal
   Kauter, Kathleen
   Sernia, Conrad
   Campbell, Fiona
   Ward, Leigh
   Gobe, Glenda
   Fenning, Andrew
   Brown, Lindsay
TI High-carbohydrate, High-fat Diet-induced Metabolic Syndrome and
   Cardiovascular Remodeling in Rats
SO JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
LA English
DT Article
DE metabolic syndrome; obesity; cardiovascular disease; hypertension;
   dyslipidemia; high-carbohydrate; high-fat diet
ID SPONTANEOUSLY HYPERTENSIVE-RATS; OXIDATIVE STRESS; INSULIN-RESISTANCE;
   CARDIAC-HYPERTROPHY; HYDROGEN-PEROXIDE; SIGNALING PATHWAYS;
   PRESSURE-OVERLOAD; SMOOTH-MUSCLE; DISEASE; OBESITY
AB The prevalence of metabolic syndrome including central obesity, insulin resistance, impaired glucose tolerance, hypertension, and dyslipidemia is increasing. Development of adequate therapy for metabolic syndrome requires an animal model that mimics the human disease state. Therefore, we have characterized the metabolic, cardiovascular, hepatic, renal, and pancreatic changes in male Wistar rats (8-9 weeks old) fed on a high-carbohydrate, high-fat diet including condensed milk (39.5%), beef tallow (20%), and fructose (17.5%) together with 25% fructose in drinking water; control rats were fed a cornstarch diet. During 16 weeks on this diet, rats showed progressive increases in body weight, energy intake, abdominal fat deposition, and abdominal circumference along with impaired glucose tolerance, dyslipidemia, hyperinsulinemia, and increased plasma leptin and malondialdehyde concentrations. Cardiovascular signs included increased systolic blood pressure and endothelial dysfunction together with inflammation, fibrosis, hypertrophy, increased stiffness, and delayed repolarization in the left ventricle of the heart. The liver showed increased wet weight, fat deposition, inflammation, and fibrosis with increased plasma activity of liver enzymes. The kidneys showed inflammation and fibrosis, whereas the pancreas showed increased islet size. In comparison with other models of diabetes and obesity, this diet-induced model more closely mimics the changes observed in human metabolic syndrome.
C1 [Panchal, Sunil K.; Kauter, Kathleen; Brown, Lindsay] Univ So Queensland, Dept Biol & Phys Sci, Toowoomba, Qld 4350, Australia.
   [Poudyal, Hemant; Iyer, Abishek; Nazer, Reeza; Alam, Md. Ashraful; Diwan, Vishal; Sernia, Conrad; Brown, Lindsay] Univ Queensland, Sch Biomed Sci, Brisbane, Qld, Australia.
   [Campbell, Fiona] Univ Queensland, Sch Vet Sci, Brisbane, Qld, Australia.
   [Ward, Leigh] Univ Queensland, Sch Chem & Mol Biosci, Brisbane, Qld, Australia.
   [Gobe, Glenda] Univ Queensland, Sch Med, Ctr Kidney Dis Res, Brisbane, Qld, Australia.
   [Fenning, Andrew] Cent Queensland Univ, Fac Sci Engn & Hlth, Rockhampton, Qld 4702, Australia.
C3 University of Southern Queensland; University of Queensland; University
   of Queensland; University of Queensland; University of Queensland;
   Central Queensland University
RP Brown, L (corresponding author), Univ So Queensland, Dept Biol & Phys Sci, Toowoomba, Qld 4350, Australia.
EM Lindsay.Brown@usq.edu.au
RI Alam, Ashraful/G-1964-2014; Ward, Leigh/L-4461-2019; Gobe,
   Glenda/G-2315-2010; Poudyal, Hemant/HOH-9324-2023; Ward,
   Leigh/A-4834-2010; Iyer, Abishek/C-9767-2017
OI Kauter, Kate/0000-0003-2470-9172; Ward, Leigh/0000-0003-2378-279X;
   Panchal, Sunil K/0000-0001-5464-3376; Iyer, Abishek/0000-0001-9533-5265
FU Prince Charles Hospital Foundation, Brisbane, Queensland, Australia; Dr.
   Red Nutraceuticals, Mt. Nebo, Queensland, Australia
FX Supported partially by grants from The Prince Charles Hospital
   Foundation, Brisbane, Queensland, Australia.We thank Mr. Greg Jardine,
   Dr. Red Nutraceuticals, Mt. Nebo, Queensland, Australia, for financial
   support to allow this project to be undertaken.
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NR 78
TC 335
Z9 359
U1 0
U2 66
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0160-2446
EI 1533-4023
J9 J CARDIOVASC PHARM
JI J. Cardiovasc. Pharmacol.
PD MAY
PY 2011
VL 57
IS 5
BP 611
EP 624
PG 14
WC Cardiac & Cardiovascular Systems; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Pharmacology & Pharmacy
GA 763NL
UT WOS:000290566200015
PM 20966763
DA 2025-06-11
ER

PT J
AU Poudyal, H
   Panchal, SK
   Diwan, V
   Brown, L
AF Poudyal, Hemant
   Panchal, Sunil K.
   Diwan, Vishal
   Brown, Lindsay
TI Omega-3 fatty acids and metabolic syndrome: Effects and emerging
   mechanisms of action
SO PROGRESS IN LIPID RESEARCH
LA English
DT Review
DE alpha-Linolenic acid; Eicosapentaenoic acid; Docosahexaenoic acid;
   Omega-3 fatty acids; Metabolic syndrome; Cardiovascular
ID ALPHA-LINOLENIC ACID; N-3 FATTY-ACIDS; FISH-OIL SUPPLEMENTATION;
   CARNITINE PALMITOYLTRANSFERASE I; ACTIVATED-RECEPTOR-ALPHA; ACYL-COA
   OXIDASE; INFLAMMATORY GENE-EXPRESSION; CONVERTING ENZYME-ACTIVITY; BLOOD
   MONONUCLEAR-CELLS; DOCOSAHEXAENOIC ACID
AB Epidemiological, human, animal, and cell culture studies show that n-3 fatty acids, especially alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA), reduce the risk factors of cardiovascular diseases. EPA and DHA, rather than ALA, have been the focus of research on the n-3 fatty acids, probably due to the relatively inefficient conversion of ALA to EPA and DHA in rodents and humans. This review will assess our current understanding of the effects and potential mechanisms of actions of individual n-3 fatty acids on multiple risk factors of metabolic syndrome. Evidence for pharmacological responses and the mechanism of action of each of the n-3 fatty acid trio will be discussed for the major risk factors of metabolic syndrome, especially adiposity, dyslipidemia, insulin resistance and diabetes, hypertension, oxidative stress, and inflammation. Metabolism of n-3 and n-6 fatty acids as well as the interactions of n-3 fatty acids with nutrients, gene expression, and disease states will be addressed to provide a rationale for the use of n-3 fatty acids to reduce the risk factors of metabolic syndrome. (C) 2011 Elsevier Ltd. All rights reserved.
C1 [Panchal, Sunil K.; Brown, Lindsay] Univ So Queensland, Dept Biol & Phys Sci, Toowoomba, Qld 4350, Australia.
   [Poudyal, Hemant; Diwan, Vishal; Brown, Lindsay] Univ Queensland, Sch Biomed Sci, Brisbane, Qld 4072, Australia.
C3 University of Southern Queensland; University of Queensland
RP Brown, L (corresponding author), Univ So Queensland, Dept Biol & Phys Sci, Toowoomba, Qld 4350, Australia.
EM Lindsay.Brown@usq.edu.au
RI Poudyal, Hemant/HOH-9324-2023
OI Panchal, Sunil K/0000-0001-5464-3376
FU NHMRC; Prince Charles Hospital Foundation; Dr. Red Nutraceuticals
FX Supported by NHMRC, The Prince Charles Hospital Foundation, Dr. Red
   Nutraceuticals.
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NR 237
TC 298
Z9 322
U1 2
U2 100
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0163-7827
EI 1873-2194
J9 PROG LIPID RES
JI Prog. Lipid Res.
PD OCT
PY 2011
VL 50
IS 4
BP 372
EP 387
DI 10.1016/j.plipres.2011.06.003
PG 16
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA 843KE
UT WOS:000296669900006
PM 21762726
DA 2025-06-11
ER

PT J
AU Lim, KBL
   Schiano, TD
AF Lim, Kieron B. L.
   Schiano, Thomas D.
TI Long-Term Outcome After Liver Transplantation
SO MOUNT SINAI JOURNAL OF MEDICINE
LA English
DT Article
DE chronic kidney disease; de novo malignancy; immunization; liver
   transplantation; long-term outcome; new-onset diabetes mellitus;
   osteoporosis; posttransplant metabolic syndrome; posttransplant quality
   of life; pregnancy
ID ONSET DIABETES-MELLITUS; HEPATITIS-C VIRUS; CHRONIC KIDNEY-DISEASE;
   DE-NOVO MALIGNANCIES; QUALITY-OF-LIFE; ACUTE-RENAL-FAILURE;
   POSTTRANSPLANT LYMPHOPROLIFERATIVE DISEASE; CARDIOVASCULAR RISK-FACTORS;
   PREVENTS BONE LOSS; METABOLIC SYNDROME
AB Liver transplantation is a life-saving therapy for patients with end-stage liver disease, acute liver failure, and liver tumors. Over the past 4 decades, improvements in surgical techniques, peritransplant intensive care, and immunosuppressive regimens have resulted in significant improvements in short-term survival. Focus has now shifted to addressing long-term complications and improving quality of life in liver recipients. These include adverse effects of immunosuppression; recurrence of the primary liver disease; and management of diabetes, hypertension, dyslipidemia, obesity, metabolic syndrome, cardiovascular disease, renal dysfunction, osteoporosis, and de novo malignancy. Issues such as posttransplant depression, employment, sexual function, fertility, and pregnancy must not be overlooked, as they have a direct impact on the liver recipient's quality of life. This review summarizes the latest data in long-term outcome after liver transplantation. Mt Sinai J Med 79:169189, 2012. (C) 2012 Mount Sinai School of Medicine
C1 [Lim, Kieron B. L.; Schiano, Thomas D.] Mt Sinai Sch Med, New York, NY 10029 USA.
   [Lim, Kieron B. L.] Natl Univ Singapore Hosp, Singapore, Singapore.
C3 Icahn School of Medicine at Mount Sinai; National University of
   Singapore
RP Schiano, TD (corresponding author), Mt Sinai Sch Med, New York, NY 10029 USA.
EM thomas.schiano@mountsinai.org
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NR 263
TC 26
Z9 28
U1 0
U2 16
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0027-2507
EI 1931-7581
J9 MT SINAI J MED
JI Mt. Sinai J. Med.
PD MAR-APR
PY 2012
VL 79
IS 2
BP 169
EP 189
DI 10.1002/msj.21302
PG 21
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 924WL
UT WOS:000302721900002
PM 22499489
DA 2025-06-11
ER

PT J
AU Halabicky, OM
   Pinto-Martin, JA
   Compton, P
   Liu, JH
AF Halabicky, Olivia M.
   Pinto-Martin, Jennifer A.
   Compton, Peggy
   Liu, Jianghong
TI Longitudinal association of early childhood lead exposure and adolescent
   heart rate variability: influence of parental education
SO JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART C-TOXICOLOGY AND
   CARCINOGENESIS
LA English
DT Article
DE Blood lead levels; parental education; social environmental factor;
   heart rate variability; physiological stress; child development
ID SOCIOECONOMIC-STATUS; SOCIODEMOGRAPHIC FACTORS; METABOLIC SYNDROME;
   ACUTE STRESS; CHILDREN; METAANALYSIS; RESPONSES; ANXIETY; HEALTH
AB Lead exposure has been shown to dysregulate physiological stress responses. However, few studies have investigated the effect of lead exposure on later heart rate variability (HRV), an indicator of a stress response, in large samples of children. Furthermore, the interaction between social environmental factors and lead exposure in childhood, which commonly co-occur, remains understudied. This study examined relationships between childhood lead exposure and early adolescent physiological stress responses at different levels of parental education. Participants were 406 children from Jintan, China. Blood lead levels (BLLs) and parental education data were collected at 3-5 years of age, and HRV outcomes assessed at 12 years via frequency domain measures (LF/HF ratio) collected during an induced stress test. Results show a significant interaction between parental education and BLLs at 3-5 years. This relationship was found to be most consistent for the interaction between BLLs and mother's years of education for both the planning (beta = 0.12, p = 0.046) and speaking (beta = 0.11, p = 0.043) phase of the stress task, suggesting that increasing years of mother's education may enhance the deleterious influence of lead exposure on the HRV frequency measure, LF/HF ratio. This research highlights the complexity in lead exposure induced outcomes.
C1 [Halabicky, Olivia M.; Pinto-Martin, Jennifer A.; Compton, Peggy; Liu, Jianghong] Univ Penn, Sch Nursing, Philadelphia, PA 19104 USA.
   [Pinto-Martin, Jennifer A.] Univ Penn, Perelman Sch Med, Dept Biostat Epidemiol & Informat, Philadelphia, PA 19104 USA.
   [Halabicky, Olivia M.] Univ Michigan, Sch Publ Hlth, 1415 Washington Hts, Ann Arbor, MI 48109 USA.
C3 University of Pennsylvania; University of Pennsylvania; University of
   Michigan System; University of Michigan
RP Liu, JH (corresponding author), Univ Penn, Sch Nursing, Philadelphia, PA 19104 USA.
EM jhliu@nursing.upenn.edu
RI Liu, Jianghong/AAE-8130-2020
OI Halabicky, Olivia/0000-0001-7386-1467
FU National Institute of Environment Health Sciences [R01-ES018858,
   K02-ES019878, K01-ES015877]; National Institute of Nursing Research
   [F31NR019527, R21 NR019047]; National Institute of Environmental Health
   Sciences [T32ES007062]; National Institute on Drug Abuse [R21 DA046364];
   National Institutes of Health [R01HD087485]; University of Pennsylvania
   Center of Excellence in Environmental Toxicology [P30-ES013508]; Robert
   Wood Johnson Foundation Future of Nursing Scholars Program; Sigma Theta
   Tau International Xi Chapter; Eunice Kennedy Shriver National Institute
   of Child Health and Human Development [R01HD087485] Funding Source: NIH
   RePORTER; National Institute of Environmental Health Sciences
   [T32ES007062] Funding Source: NIH RePORTER; National Institute of
   Nursing Research [R21NR019047] Funding Source: NIH RePORTER
FX The authors thankfully acknowledge the participating children and their
   families from Jintan City and those who set up the Jintan
   psychophysiology lab Anna Rudo-Hutt, Adrian Raine, and Richard Liu. We
   additionally thank Ryan Quinn for his assistance with the statistical
   analysis of this study. Funding for the cohort study was provided by the
   National Institute of Environment Health Sciences under Grants
   (R01-ES018858; K02-ES019878; K01-ES015877). Additional funding
   supporting the authors did not contribute to the study design or data
   collection, analysis, or interpretation: National Institute of Nursing
   Research under Grant (F31NR019527; R21 NR019047); the National Institute
   of Environmental Health Sciences under Grant (T32ES007062); the National
   Institute on Drug Abuse under Grant (R21 DA046364); National Institutes
   of Health under Grant (R01HD087485); the University of Pennsylvania
   Center of Excellence in Environmental Toxicology under Grant
   (P30-ES013508); the Robert Wood Johnson Foundation Future of Nursing
   Scholars Program; and Sigma Theta Tau International Xi Chapter.
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NR 61
TC 1
Z9 1
U1 1
U2 6
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 2689-6583
EI 2689-6591
J9 J ENV SCI HEAL C-TOX
JI J. Environ. Sci. Health Part C-Toxicol. Carcinogen.
PD APR 3
PY 2022
VL 40
IS 2
BP 133
EP 153
DI 10.1080/26896583.2022.2060689
EA APR 2022
PG 21
WC Oncology; Environmental Sciences; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Environmental Sciences & Ecology; Toxicology
GA 3J9SF
UT WOS:000799154900001
PM 35895919
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Bautista-Expósito, S
   Peñas, E
   Frias, J
   Martínez-Villaluenga, C
AF Bautista-Exposito, Sara
   Penas, Elena
   Frias, Juana
   Martinez-Villaluenga, Cristina
TI Pilot-scale produced fermented lentil protects against
   t-BHP-triggered oxidative stress by activation of Nrf2 dependent
   on SAPK/JNK phosphorylation
SO FOOD CHEMISTRY
LA English
DT Article
DE Nfr2; Lentil; Digestion; Peptides; Phenolic compounds; Oxidative stress
ID PHASEOLUS-VULGARIS L.; PH-CONTROLLED FERMENTATION; METABOLIC SYNDROME;
   ANTIOXIDANT ACTIVITY; SIGNALING PATHWAYS; RISK-FACTORS; PEPTIDES;
   PROTEINS; PULSES; CONSUMPTION
AB Fermented lentil (FL) produced using L. plantarum and Savinase in alkaline conditions relieves metabolic alterations and oxidative stress in Zucker rats with metabolic syndrome. Here, we investigated the effect of up scaling the fermentation process on chemical composition and biological activity of FL. Moreover, we studied the molecular mechanisms by which FL exert a cytoprotective effect against oxidative stress in tert-butyl hydroperoxide (t-BHP)-challenged RAW264.7 macrophages. Up-scale production reduced overall biological effectiveness of FL with the exception of inhibition of intracellular ROS generation. FL prevented t-BHP-induced cytotoxicity and intracellular accumulation of reactive oxygen species through activation of catalase expression via SAPK/JNK phosphorylation and Nrf2 nuclear translocation. Different oligopeptides, phenolic acids and flavonols were identified as contributors of the observed effects. To the best of our knowledge, we reported for the first time that FL attenuates oxidative stress cellular damage via activation of SAPK/JNK phosphorylation, Nrf2 nuclear translocation and antioxidant enzymes expression.
C1 [Bautista-Exposito, Sara; Penas, Elena; Frias, Juana; Martinez-Villaluenga, Cristina] Inst Food Sci Technol & Nutr ICTAN CSIC, Juan de la Cierva 3, Madrid 28006, Spain.
C3 Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Instituto
   de Ciencia y Tecnologia de Alimentos y Nutricion (ICTAN)
RP Martínez-Villaluenga, C (corresponding author), C Juan de la Cierva 3, Madrid 28006, Spain.
EM c.m.villaluenga@csic.es
RI Peñas, Elena/C-8557-2015; Martinez-Villaluenga, Cristina/AAK-7199-2021;
   Frias, Juana/F-6607-2013
OI Bautista Exposito, Sara/0000-0002-9099-2247; Frias,
   Juana/0000-0003-0355-3113
FU Ministry of Economy and Competitiveness (MINECO, Spain)
   [AGL2013-43247-R]; FEDER program [AGL2013-43247-R]; Spanish National
   Research Council [201670I044]
FX The research leading to these results received funding from Ministry of
   Economy and Competitiveness (MINECO, Spain) and FEDER program [grant
   number AGL2013-43247-R] and Spanish National Research Council [grant
   number 201670I044]. E.P. acknowledges to MINECO and European Social Fund
   for her "Ramon y Cajal" contract.
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NR 42
TC 9
Z9 9
U1 0
U2 85
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0308-8146
EI 1873-7072
J9 FOOD CHEM
JI Food Chem.
PD FEB 15
PY 2019
VL 274
BP 750
EP 759
DI 10.1016/j.foodchem.2018.09.012
PG 10
WC Chemistry, Applied; Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Food Science & Technology; Nutrition & Dietetics
GA GX9RE
UT WOS:000448141800096
PM 30373004
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Gaughran, F
   Stahl, D
   Ismail, K
   Greenwood, K
   Atakan, Z
   Gardner-Sood, P
   Stubbs, B
   Hopkins, D
   Patel, A
   Lally, J
   Lowe, P
   Arbuthnot, M
   Orr, D
   Corlett, S
   Eberhard, J
   David, AS
   Murray, R
   Smith, S
AF Gaughran, Fiona
   Stahl, Daniel
   Ismail, Khalida
   Greenwood, Kathryn
   Atakan, Zerrin
   Gardner-Sood, Poonam
   Stubbs, Brendon
   Hopkins, David
   Patel, Anita
   Lally, John
   Lowe, Philippa
   Arbuthnot, Maurice
   Orr, Diana
   Corlett, Sarah
   Eberhard, Jonas
   David, Anthony S.
   Murray, Robin
   Smith, Shubulade
CA IMPaCT Team
TI Randomised control trial of the effectiveness of an integrated
   psychosocial health promotion intervention aimed at improving health and
   reducing substance use in established psychosis (IMPaCT)
SO BMC PSYCHIATRY
LA English
DT Article
DE Mortality; Health promotion intervention; Psychosis; Quality of life;
   Schizophrenia
ID CARDIOVASCULAR RISK-FACTORS; MENTAL-ILLNESS; METABOLIC SYNDROME;
   WEIGHT-LOSS; PEOPLE; SCHIZOPHRENIA; DISORDERS; DISEASE; ANTIPSYCHOTICS;
   MAINTENANCE
AB Background: People with psychosis have a reduced life expectancy of 10-20 years, largely due to cardiovascular disease. This trial aimed to determine the effectiveness of a modular health promotion intervention (IMPaCT Therapy) in improving health and reducing cardiovascular risk in psychosis.
   Methods: A multicentre, two arm, parallel cluster RCT was conducted across five UK mental health NHS trusts. Community care coordinators (CC) were randomly assigned to training and supervision in delivering IMPaCT Therapy or treatment as usual (TAU) to current patients with psychosis (cluster). The primary outcome was the physical and mental health subscales of the Short form-36 (SF-36) questionnaire.
   Results: Of 104 care coordinators recruited, 52 (with 213 patients) were randomised to deliver IMPaCT therapy and 52 (with 193 patients) randomised to TAU. Of 406 patients, 318 (78%) and 301 (74%) attended 12-and 15-month follow-up respectively. IMPaCT therapy showed no significant effect on the physical or mental health component SF-36 scores versus TAU at 12 or 15 months. No effect was observed for cardiovascular risk indicators, except for HDL cholesterol, which improved more with IMPACT therapy than TAU (Treatment effect (95% CI); 0.085 (0.007 to 0.16); p = 0.034). The 22% of patients who received > 180 min of IMPACT Therapy in addition to usual care achieved a greater reduction in waist circumference than did controls, which was clinically significant.
   Conclusion: Training and supervising community care coordinators to use IMPaCT therapy in patients with psychosis is insufficient to significantly improve physical or mental health quality of life. The search for effective, pragmatic interventions deliverable in health care services continues.
C1 [Gaughran, Fiona] South London & Maudsley NHS Fdn Trust, Natl Psychosis Serv, London, England.
   [Gaughran, Fiona; Atakan, Zerrin; Gardner-Sood, Poonam; Lally, John; Eberhard, Jonas; Murray, Robin] Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Psychosis Studies, London, England.
   [Stahl, Daniel] Kings Coll London, Biostat Dept, Inst Psychiat Psychol & Neurosci, Denmark Hill, London, England.
   [Ismail, Khalida] Kings Coll London, Dept Psychol Med, Inst Psychiat Psychol & Neurosci, Denmark Hill, London, England.
   [Greenwood, Kathryn] Univ Sussex, Sussex Partnership NHS Fdn Trust, Brighton, E Sussex, England.
   [Greenwood, Kathryn] Univ Sussex, Sch Psychol, Brighton, E Sussex, England.
   [Stubbs, Brendon] Kings Coll London, Inst Psychiat, Hlth Serv & Populat Res Dept, London, England.
   [Stubbs, Brendon] South London & Maudsley NHS Fdn Trust, Physiotherapy Dept, London, England.
   [Hopkins, David] Kings Coll Hosp NHS Fdn Trust, Kings Hlth Partners, Dept Diabet Med, London, England.
   [Patel, Anita] Queen Mary Univ London, Hlth Econ, Ctr Primary Care & Publ Hlth, Blizard Inst, London, England.
   [Lally, John] South London & Maudsley NHS Fdn Trust, Natl Psychosis Serv, London, England.
   [Lowe, Philippa] Rethink Mental Illness, Trustees, London, England.
   [Corlett, Sarah] London Borough Lambeth, Publ Hlth, London, England.
   [Eberhard, Jonas] Lund Univ, Dept Clin Sci, Lund, Sweden.
   [David, Anthony S.] Kings Coll London, Inst Psychiat Psychol & Neurosci, Denmark Hill, London, England.
   [Smith, Shubulade] Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Forens & Neurodev Sci, Denmark Hill, London, England.
   [Smith, Shubulade] South London & Maudsley NHS Fdn Trust, Forens Intens Care Serv, London, England.
C3 South London & Maudsley NHS Trust; University of London; King's College
   London; University of London; King's College London; University of
   London; King's College London; University of Sussex; University of
   Sussex; University of London; King's College London; South London &
   Maudsley NHS Trust; King's College Hospital NHS Foundation Trust;
   University of London; King's College London; University of London; Queen
   Mary University London; South London & Maudsley NHS Trust; Lund
   University; University of London; King's College London; University of
   London; King's College London; South London & Maudsley NHS Trust
RP Gaughran, F (corresponding author), South London & Maudsley NHS Fdn Trust, Natl Psychosis Serv, London, England.; Gaughran, F (corresponding author), Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Psychosis Studies, London, England.
EM fiona.p.gaughran@kcl.ac.uk
RI Hopkins, David/AAP-4541-2020; greenwood, kathryn/I-8638-2012; Stubbs,
   Brendon/X-1904-2018; Patel, Anita/F-9832-2010; David,
   Anthony/O-1750-2019; Gaughran, Fiona/AAC-7160-2019; Stubbs,
   Brendon/C-5696-2015; murray, robin/F-8658-2012; David,
   Anthony/C-1315-2011; Stahl, Daniel/B-9713-2011; Heslin,
   Margaret/C-4307-2014; Firdosi, Muhammad/P-7974-2019; Gaughran,
   Fiona/H-5495-2011
OI Ismail, Khalida/0000-0001-6084-449X; Greenwood,
   Kathryn/0000-0001-7899-8980; Kolliakou, Anna/0000-0003-1234-4129;
   Stubbs, Brendon/0000-0001-7387-3791; murray, robin/0000-0003-0829-0519;
   David, Anthony/0000-0003-0967-774X; Breedvelt, J J
   F/0000-0002-4372-8718; Lally, John/0000-0003-3038-0625; Di Forti,
   Marta/0000-0002-3218-6925; Stahl, Daniel/0000-0001-7987-6619; Treasure,
   Janet/0000-0003-0871-4596; Hopkins, David/0000-0002-0451-0900; Heslin,
   Margaret/0000-0002-3094-9255; Patel, Anita/0000-0003-0769-1732;
   Papanastasiou, Evangelos/0000-0002-8029-666X; Firdosi,
   Muhammad/0000-0002-8450-6484; Gaughran, Fiona/0000-0001-7414-5569
FU National Institute for Health Research (NIHR) under IMPACT Programme
   [RP-PG-0606-1049]; National Institute for Health Research (NIHR)
   Biomedical Research Centre at South London and Maudsley NHS Foundation
   Trust; King's College London; National Institute for Health Research
   Collaboration for Leadership in Applied Health Research & Care Funding
   scheme; MRC [MR/N026063/1] Funding Source: UKRI
FX This paper summarises independent research funded by the National
   Institute for Health Research (NIHR) under its IMPACT Programme (Grant
   Reference Number RP-PG-0606-1049) and had support from the National
   Institute for Health Research (NIHR) Biomedical Research Centre at South
   London and Maudsley NHS Foundation Trust and King's College London. BS
   and FG are, in part, funded by the National Institute for Health
   Research Collaboration for Leadership in Applied Health Research & Care
   Funding scheme. The views expressed in this publication are those of the
   authors and not necessarily those of the NHS, the National Institute for
   Health Research or the Department of Health. Neither the funding source
   nor the sponsor had any role in the design of this study or its
   execution, analyses, interpretation of the data, or decision to submit
   results.
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NR 48
TC 29
Z9 31
U1 1
U2 17
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-244X
J9 BMC PSYCHIATRY
JI BMC Psychiatry
PD DEC 28
PY 2017
VL 17
AR 413
DI 10.1186/s12888-017-1571-0
PG 14
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA FR6NC
UT WOS:000419181800006
PM 29284438
OA Green Published, gold, Green Accepted
DA 2025-06-11
ER

PT J
AU Zhu, HD
   Chao, J
   Kotak, I
   Guo, DH
   Parikh, SJ
   Bhagatwala, J
   Dong, YT
   Patel, SY
   Houk, C
   Chao, L
   Dong, YB
AF Zhu, Haidong
   Chao, Julie
   Kotak, Ishita
   Guo, Dehuang
   Parikh, Samip J.
   Bhagatwala, Jigar
   Dong, Yutong
   Patel, Sagar Y.
   Houk, Chris
   Chao, Lee
   Dong, Yanbin
TI Plasma kallistatin is associated with adiposity and cardiometabolic risk
   in apparently healthy African American adolescents
SO METABOLISM-CLINICAL AND EXPERIMENTAL
LA English
DT Article
DE Obesity; Lipids; Inflammation
ID TISSUE KALLIKREIN INHIBITOR; CELLULAR-LOCALIZATION; DIABETES-MELLITUS;
   OXIDATIVE STRESS; BLOOD-PRESSURE; INFLAMMATION; ACTIVATION; YOUTH;
   OVERWEIGHT; EXPRESSION
AB Objective. Itis generally recognized that obesity and cardiometabolic risk are more prevalent in African Americans. Kallistatin, a novel tissue kallikrein inhibitor, has anti-inflammatory and antioxidant properties. Thus, the goal of this study was to examine the relationships among plasma kallistatin levels, adiposity and cardiometabolic risk factors in African American adolescents.
   Materials/Methods. Plasma kallistatin levels were determined in 318 apparently healthy African American adolescents (aged 14-19 years, 48.1% females) by enzyme-linked immunosorbent assay.
   Results. Plasma kallistatin levels did not differ between males (27.9 +/- 11.2 mu g/mL) and females (26.8 +/- 11.0 mu g/mL) (p=0.47). Plasma kallistatin levels were inversely correlated with percent body fat (% BF, r=-0.13, p=0.04), total cholesterol (r=-0.28, p<0.01), low density lipoprotein cholesterol (LDL, r=0.30, p<0.01) and interleukin-6 (r=-0.14, p=0.05), but positively correlated with adiponectin (r=0.16, p=0.03) and high density lipoprotein (HDL, r=0.17, p=0.02). These correlations remained significant after adjustment for age, sex and body mass index percentiles. Stepwise multiple linear regression analysis showed that LDL cholesterol alone explained 14.2% of the variance in kallistatin, while % BF and adiponectin explained an additional 3.6% and 2.8% of the variance, respectively.
   Conclusions. The present study demonstrates that plasma kallistatin levels are inversely associated with adiposity, adverse lipid profiles and inflammation in apparently healthy African American adolescents. As a potent antioxidant and anti-inflammation agent, kallistatin may also hold therapeutic promise in cardiometabolic disorders. (C) 2013 Elsevier Inc. All rights reserved.
C1 [Zhu, Haidong; Kotak, Ishita; Guo, Dehuang; Parikh, Samip J.; Bhagatwala, Jigar; Dong, Yutong; Patel, Sagar Y.; Dong, Yanbin] Georgia Hlth Sci Univ, Dept Pediat, Georgia Prevent Inst, Augusta, GA 30912 USA.
   [Chao, Julie; Chao, Lee] Med Univ S Carolina, Dept Biochem & Mol Biol, Charleston, SC 29425 USA.
   [Parikh, Samip J.; Bhagatwala, Jigar] Georgia Hlth Sci Univ, Dept Internal Med, Augusta, GA USA.
   [Houk, Chris] Georgia Hlth Sci Univ, Dept Pediat, Div Endocrinol, Augusta, GA USA.
C3 University System of Georgia; Augusta University; Medical University of
   South Carolina; University System of Georgia; Augusta University;
   University System of Georgia; Augusta University
RP Dong, YB (corresponding author), Georgia Hlth Sci Univ, Dept Pediat, Georgia Prevent Inst, HS-1640, Augusta, GA 30912 USA.
EM YDONG@georgiahealth.edu
RI Zhu, Haidong/AAD-1865-2021; Parikh, Samip/AAI-6909-2020; Dong,
   Yutong/I-8654-2016
FU National Institutes of Health [HL077230, HL044083]
FX Funding was provided by National Institutes of Health grants HL077230
   and HL044083.
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NR 27
TC 25
Z9 27
U1 0
U2 2
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0026-0495
J9 METABOLISM
JI Metab.-Clin. Exp.
PD MAY
PY 2013
VL 62
IS 5
BP 642
EP 646
DI 10.1016/j.metabol.2012.10.012
PG 5
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 135BH
UT WOS:000318260500005
PM 23190873
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Jackson, EK
   Gillespie, DG
   Mi, ZC
   Birder, LA
   Tofovic, SP
AF Jackson, Edwin K.
   Gillespie, Delbert G.
   Mi, Zaichuan
   Birder, Lori A.
   Tofovic, Stevan P.
TI 8-Aminoguanine and its actions in the metabolic syndrome
SO SCIENTIFIC REPORTS
LA English
DT Article
DE 8-Aminoguanine; Metabolic syndrome; Inosine; Hypoxanthine; Interleukin-1
   beta; Angiotensin II
ID PURINE NUCLEOSIDE PHOSPHORYLASE; ADENOSINE RECEPTOR; OXIDATIVE STRESS;
   INOSINE; GUANOSINE; KIDNEY; MODEL; CELL; RAT; INFLAMMATION
AB The metabolic syndrome is characterized by obesity, insulin resistance, dyslipidemia and hypertension and predisposes to cardiorenal injury. Here, we tested our hypothesis that 8-aminoguanine, an endogenous purine, exerts beneficial effects in Zucker Diabetic-Sprague Dawley (ZDSD) rats, a preclinical model of the metabolic syndrome. ZDSD rats were instrumented for blood pressure radiotelemetry and randomized to vehicle or 8-aminoguanine (10 mg/kg/day, po). The protocol was divided into four phases: Phase 1: 17 days of tap water/normal diet; Phase 2: 30 days of 1% saline/normal diet; Phase 3: 28 days of 1% saline/diabetogenic diet; Phase 4: acute/terminal measurements. 8-Aminoguanine: (1) decreased mean arterial blood pressure (P = 0.0004; 119.5 +/- 1.0 (vehicle) versus 116.3 +/- 1.0 (treated) mmHg) throughout all three phases of the radiotelemetry study; (2) rebalanced the purine metabolome away from hypoxanthine (pro-inflammatory) and towards inosine (anti-inflammatory); (3) reduced by 71% circulating IL-1 beta, a cytokine that contributes to hypertension-induced adverse cardiovascular events and type 2 diabetes; (4) attenuated renovascular responses to angiotensin II; (5) improved cardiac and renal histopathology; (6) attenuated diet-induced polydipsia/polyuria; and (7) reduced HbA1c. In the metabolic syndrome, 8-aminoguanine lowers blood pressure, improves diabetes and reduces organ damage, likely by rebalancing the purine metabolome leading to reductions in injurious cytokines such as IL-1 beta.
C1 [Jackson, Edwin K.; Gillespie, Delbert G.; Mi, Zaichuan; Birder, Lori A.; Tofovic, Stevan P.] Univ Pittsburgh, Sch Med, Dept Pharmacol & Chem Biol, Pittsburgh, PA 15219 USA.
   [Birder, Lori A.] Univ Pittsburgh, Sch Med, Dept Med, Pittsburgh, PA 15261 USA.
   [Jackson, Edwin K.] Univ Pittsburgh, Sch Med, Dept Pharmacol & Chem Biol, 100 Technol Dr,Room 514, Pittsburgh, PA 15219 USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE); University
   of Pittsburgh; Pennsylvania Commonwealth System of Higher Education
   (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of
   Higher Education (PCSHE); University of Pittsburgh
RP Jackson, EK (corresponding author), Univ Pittsburgh, Sch Med, Dept Pharmacol & Chem Biol, Pittsburgh, PA 15219 USA.; Jackson, EK (corresponding author), Univ Pittsburgh, Sch Med, Dept Pharmacol & Chem Biol, 100 Technol Dr,Room 514, Pittsburgh, PA 15219 USA.
EM edj@pitt.edu
FU National Institutes of Health [HL109002, DK135076]
FX This study was funded by National Institutes of Health (Nos. HL109002,
   DK135076).
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NR 62
TC 1
Z9 1
U1 2
U2 2
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD SEP 30
PY 2024
VL 14
IS 1
AR 22652
DI 10.1038/s41598-024-73159-4
PG 21
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA H8S4Q
UT WOS:001326080400085
PM 39349636
OA gold
DA 2025-06-11
ER

PT J
AU Gharipour, M
   Mani, A
   Baghbahadorani, MA
   Cardoso, CKD
   Jahanfar, S
   Sarrafzadegan, N
   de Oliveira, C
   Silveira, EA
AF Gharipour, Mojgan
   Mani, Arya
   Baghbahadorani, Mona Amini
   Cardoso, Camila Kellen de Souza
   Jahanfar, Shayesteh
   Sarrafzadegan, Nizal
   de Oliveira, Cesar
   Silveira, Erika Aparecida
TI How Are Epigenetic Modifications Related to Cardiovascular Disease in
   Older Adults?
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE epigenetics; older adults; cardiovascular disease; aging; lifestyle;
   environment; physical inactivity; diet; nutrients; caffeine; alcohol
   consumption
ID DNA-METHYLATION; PHYSICAL-ACTIVITY; OXIDATIVE STRESS; GENE-EXPRESSION;
   ENDOTHELIAL DYSFUNCTION; PROMOTER METHYLATION; METABOLIC SYNDROME;
   ELDERLY-PATIENTS; LEUKOCYTE DNA; RISK-FACTORS
AB The rate of aging has increased globally during recent decades and has led to a rising burden of age-related diseases such as cardiovascular disease (CVD). At the molecular level, epigenetic modifications have been shown recently to alter gene expression during the life course and impair cellular function. In this regard, several CVD risk factors, such as lifestyle and environmental factors, have emerged as key factors in epigenetic modifications within the cardiovascular system. In this study, we attempted to summarized recent evidence related to epigenetic modification, inflammation response, and CVD in older adults as well as the effect of lifestyle modification as a preventive strategy in this age group. Recent evidence showed that lifestyle and environmental factors may affect epigenetic mechanisms, such as DNA methylation, histone acetylation, and miRNA expression. Several substances or nutrients such as selenium, magnesium, curcumin, and caffeine (present in coffee and some teas) could regulate epigenetics. Similarly, physical inactivity, alcohol consumption, air pollutants, psychological stress, and shift working are well-known modifiers of epigenetic patterns. Understanding the exact ways that lifestyle and environmental factors could affect the expression of genes could help to influence the time of incidence and severity of aging-associated diseases. This review highlighted that a healthy lifestyle throughout the life course, such as a healthy diet rich in fibers, vitamins, and essential elements, and specific fatty acids, adequate physical activity and sleep, smoking cessation, and stress control, could be useful tools in preventing epigenetic changes that lead to impaired cardiovascular function.
C1 [Gharipour, Mojgan; Sarrafzadegan, Nizal] Isfahan Univ Med Sci, Isfahan Cardiovasc Res Ctr, Cardiovasc Res Inst, Esfahan 8158388994, Iran.
   [Mani, Arya] Yale Univ, Cardiovasc Res Ctr, Dept Internal Med, Sch Med, New Haven, CT 06520 USA.
   [Mani, Arya] Yale Univ, Dept Genet, Sch Med, New Haven, CT 06520 USA.
   [Baghbahadorani, Mona Amini] Isfahan Univ Med Sci, Intervent Cardiol Res Ctr, Cardiovasc Res Inst, Esfahan 8158388994, Iran.
   [Cardoso, Camila Kellen de Souza] Pontifical Catholic Univ Goias, Sch Social Sci & Hlth, Nutr Course, BR-74605010 Goiania, Go, Brazil.
   [Jahanfar, Shayesteh] Tufts Univ, Dept Publ Hlth & Community Med, Sch Med, Boston, MI 02111 USA.
   [Sarrafzadegan, Nizal] Univ British Columbia, Fac Med, Sch Populat & Publ Hlth, Vancouver, BC V6T 1Z3, Canada.
   [de Oliveira, Cesar; Silveira, Erika Aparecida] UCL, Inst Epidemiol & Hlth Care, Dept Epidemiol & Publ Hlth, London WC1E 6BT, England.
   [Silveira, Erika Aparecida] Univ Fed Goias, Fac Med, Grad Program Hlth Sci, BR-74690900 Goiania, Go, Brazil.
C3 Isfahan University of Medical Sciences; Yale University; Yale
   University; Isfahan University of Medical Sciences; University of
   British Columbia; University of London; University College London;
   Universidade Federal de Goias
RP Sarrafzadegan, N (corresponding author), Univ British Columbia, Fac Med, Sch Populat & Publ Hlth, Vancouver, BC V6T 1Z3, Canada.; Silveira, EA (corresponding author), UCL, Inst Epidemiol & Hlth Care, Dept Epidemiol & Publ Hlth, London WC1E 6BT, England.; Silveira, EA (corresponding author), Univ Fed Goias, Fac Med, Grad Program Hlth Sci, BR-74690900 Goiania, Go, Brazil.
EM gharipour@crc.mui.ac.ir; arya.mani@yale.edu;
   amini.mona1995.ma@gmail.com; camilacardoso_nut@hotmail.com;
   shayesteh.jahanfar@tufts.edu; nizal.sarrafzadegan@ubc.ca;
   c.oliveira@ucl.ac.uk; erikasil@terra.com.br
RI Gharipour, Mojgan/AGY-5454-2022; de Oliveira, Cesar/B-5251-2019;
   Silveira, Erika Aparecida/O-7585-2018; Jahanfar, Shayesteh/B-6304-2019
OI aminibaghbadorani, mona/0000-0002-0282-2687; De Oliveira,
   Cesar/0000-0002-4099-4762; Cardoso, Camila/0000-0002-1246-5572;
   Gharipour, Mojgan/0000-0001-7397-1172; Silveira, Erika
   Aparecida/0000-0002-8839-4520; Jahanfar, Shayesteh/0000-0001-6149-1067
FU Economic and Social Research Council (ESRC) [ES/T008822/11]
FX Cesar de Oliveira received support from the Economic and Social Research
   Council (ESRC), grant number ES/T008822/11.
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NR 163
TC 13
Z9 13
U1 1
U2 14
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD SEP
PY 2021
VL 22
IS 18
AR 9949
DI 10.3390/ijms22189949
PG 18
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Biochemistry & Molecular Biology; Chemistry
GA UW6JX
UT WOS:000700260700001
PM 34576113
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Rombola, L
   De Rasis, E
   Sakurada, S
   Sakurada, T
   Corasaniti, MT
   Bagetta, G
   Scuteri, D
   Morrone, LA
AF Rombola, Laura
   De Rasis, Enrica
   Sakurada, Shinobu
   Sakurada, Tsukasa
   Corasaniti, Maria Tiziana
   Bagetta, Giacinto
   Scuteri, Damiana
   Morrone, Luigi Antonio
TI Motor behavior induced by bergamot essential oil in experimental tasks
   is differentially modulated by pretreatment with metabotropic glutamate
   receptor 2/3 or 5 antagonists
SO PHYTOTHERAPY RESEARCH
LA English
DT Article
DE anxiety; bergamot essential oil; mGlu receptor antagonists; motor
   coordination; motor impairment
ID NF-KAPPA-B; ACTIVATED PROTEIN-KINASE; TLR4/NF-KAPPA-B SIGNALING PATHWAY;
   INDUCED INFLAMMATORY CHANGES; OXIDATIVE STRESS; TRANSCRIPTION FACTOR;
   METABOLIC SYNDROME; CELL-CYCLE; OSTEOCLAST DIFFERENTIATION;
   DIABETIC-NEPHROPATHY
AB Bergamot essential oil shows anxiolytic-relaxant effects devoid of sedative action and motor impairment typical of benzodiazepines. Considering the potential for clinical of these effects, it is important to understand the underlying mechanisms of the phytocomplex. Modulation of glutamate group I and II metabotropic receptors is involved in stress and anxiety disorders, in cognition and emotions and increases locomotor activity and wakefulness. Interestingly, early data indicate that bergamot essential oil modulates glutamatergic transmission in specific manifestations of the central nervous system. The aim of this work is to investigate if selective antagonists of metabotropic glutamate 2/3 and 5 receptors affect behavioral parameters modulated by the phytocomplex. Male Wistar rats were used to measure behavioral parameters to correlate anxiety and motor activity using elevated plus maze (EPM), open field (OF), and rotarod tasks. Bergamot essential oil increases in EPM the time spent in open/closed arms and reduces total number of entries. The essential oil also increases immobility in EPM and OF and not affect motor coordination in rotarod. Pretreatment with the metabotropic glutamate antagonists does not affect the time spent in open/close arms, however, differently affects motor behavior measured after administration of phytocomplex. Particularly, glutamate 2/3 antagonist reverts immobility and glutamate 5 antagonist potentiates this parameter induced by the phytocomplex. Our data show that modulation of both metabotropic glutamate receptors is likely involved in some of behavioral effects of bergamot essential oil.
   Metabotropic receptors are differently involved in motor behavior observed with BEO. image
C1 [Rombola, Laura; De Rasis, Enrica; Bagetta, Giacinto; Morrone, Luigi Antonio] Univ Calabria, Dept Pharm Hlth & Nutr Sci, Preclin & Translat Pharmacol, Arcavacata Di Rende, Italy.
   [Sakurada, Shinobu] Tohoku Med & Pharmaceut Univ, Fac Pharmaceut Sci, Dept Physiol & Anat, Sendai, Japan.
   [Sakurada, Tsukasa] Daiichi Coll Pharmaceut Sci, Dept Pharmacol 1, Fukuoka, Japan.
   [Corasaniti, Maria Tiziana; Scuteri, Damiana] Magna Graecia Univ Catanzaro, Dept Hlth Sci, Catanzaro, Italy.
   [Rombola, Laura; Morrone, Luigi Antonio] Univ Calabria, Dept Pharm Hlth & Nutr Sci, Preclin & Translat Pharmacol, I-87036 Arcavacata Di Rende, Italy.
C3 University of Calabria; Tohoku Medical & Pharmaceutical University;
   Magna Graecia University of Catanzaro; University of Calabria
RP Rombola, L; Morrone, LA (corresponding author), Univ Calabria, Dept Pharm Hlth & Nutr Sci, Preclin & Translat Pharmacol, I-87036 Arcavacata Di Rende, Italy.
EM laura.rombola@unical.it; luigi.morrone@unical.it
RI Bagetta, Giacinto/N-9716-2018; SCUTERI, DAMIANA/AAX-5571-2020;
   CORASANITI, Maria Tiziana/N-1332-2015; Bagetta, Giacinto/E-8402-2012
OI Rombola, Laura/0000-0002-1727-3158; De Rasis,
   Enrica/0009-0008-1222-1974; CORASANITI, Maria
   Tiziana/0000-0001-6472-0697; Bagetta, Giacinto/0000-0001-8540-6218
FU Universit della Calabria
FX We thank Guido Fico for skilful technical support.
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NR 67
TC 1
Z9 1
U1 2
U2 8
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0951-418X
EI 1099-1573
J9 PHYTOTHER RES
JI Phytother. Res.
PD JUL
PY 2024
VL 38
IS 7
BP 3296
EP 3306
DI 10.1002/ptr.8206
EA APR 2024
PG 11
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA YV7A3
UT WOS:001202499000001
PM 38619875
OA hybrid
DA 2025-06-11
ER

PT J
AU Hurtado, MD
   Tama, E
   Fansa, S
   Ghusn, W
   Anazco, D
   Acosta, A
   Faubion, SS
   Shufelt, CL
AF Hurtado, Maria D.
   Tama, Elif
   Fansa, Sima
   Ghusn, Wissam
   Anazco, Diego
   Acosta, Andres
   Faubion, Stephanie S.
   Shufelt, Chrisandra L.
TI Weight loss response to semaglutide in postmenopausal women with and
   without hormone therapy use
SO MENOPAUSE-THE JOURNAL OF THE MENOPAUSE SOCIETY
LA English
DT Article
DE Antiobesity medications; Hormone therapy; Menopause; Obesity;
   Semaglutide
ID ESTROGEN PLUS PROGESTIN; REPLACEMENT THERAPY; BODY-COMPOSITION; MIDLIFE
   WOMEN; UNITED-STATES; HEALTH; MENOPAUSE; OVERWEIGHT; OBESITY; GAIN
AB In postmenopausal women with overweight or obesity treated with semaglutide, hormone therapy use was associated with an improved weight loss response. This association was maintained when adjusted for confounders.
   ObjectiveTo compare weight loss response and changes in cardiometabolic risk markers in postmenopausal women using semaglutide with and without menopause hormone therapy (HT) use.MethodsRetrospective cohort study of postmenopausal women treated with semaglutide for overweight or obesity for >= 3 months. Endpoints: total body weight loss percentage (TBWL%) at 3, 6, 9, and 12 months after semaglutide initiation; and percentage of women achieving >= 5% and >= 10% TBWL and changes in cardiometabolic risk markers (glucose, blood pressure, and lipids) at 12 months.ResultsThere were 16 women on HT and 90 on no-HT; mean age 56 +/- 8 vs 59 +/- 8 yr, P = 0.2 and mean BMI 36 +/- 5 vs 39 +/- 8 kg/m2, P = 0.1; respectively. Among women on no-HT, White race, dyslipidemia, and depression were more prevalent. Women on HT had a higher TBWL% at 3, 6, 9, and 12 months: 7 +/- 3% vs 5 +/- 4%, P = 0.01; 13 +/- 6% vs 9 +/- 5%, P = 0.01; 15 +/- 6% vs 10 +/- 6%, P = 0.02; and 16 +/- 6% vs 12 +/- 8%, P = 0.04; respectively. After adjusting for potential confounders, this association remained significant across time. At 12 months, a greater percentage of women on HT achieved >= 5% and >= 10% TBWL. Both groups experienced an improvement in cardiometabolic risk markers.ConclusionIn postmenopausal women with overweight or obesity treated with semaglutide, HT use was associated with an improved weight loss response. This association was maintained when adjusted for confounders. Larger studies should be conducted to confirm these results.
C1 [Hurtado, Maria D.; Tama, Elif] Dept Med, Div Endocrinol Diabet & Metab, Mayo Clin, Jacksonville, FL USA.
   [Hurtado, Maria D.; Tama, Elif; Fansa, Sima; Ghusn, Wissam; Anazco, Diego; Acosta, Andres] Dept Med, Precis Med Obes Program, Div Gastroenterol & Hepatol, Mayo Clin, Rochester, MN USA.
   [Faubion, Stephanie S.; Shufelt, Chrisandra L.] Dept Med, Div Gen Internal Med, Mayo Clin, Jacksonville, FL USA.
   [Faubion, Stephanie S.; Shufelt, Chrisandra L.] Womens Hlth Res Ctr, Mayo Clin, Rochester, MN USA.
   [Hurtado, Maria D.] Dept Internal Med, Div Endocrinol Diabet & Metab, 4500 San Pablo Rd S, Jacksonville, FL 32256 USA.
C3 Mayo Clinic; Mayo Clinic; Mayo Clinic; Mayo Clinic
RP Hurtado, MD (corresponding author), Dept Internal Med, Div Endocrinol Diabet & Metab, 4500 San Pablo Rd S, Jacksonville, FL 32256 USA.
EM Hurtado.mariadaniela@mayo.edu; tama.elif@mayo.edu; Fansa.Sima@mayo.edu;
   Wissamghusn7@gmail.com; anazcovillarreal.diego@mayo.edu;
   Acosta.Andres@mayo.edu; faubion.stephanie@mayo.edu;
   shufelt.chrisandra@mayo.edu
RI Ghusn, Wissam/JVD-9767-2024; Anazco, Diego/ITV-8804-2023
FU NIH [K12HD065987]; Mayo Clinic Center for Women's Health Research
FX : This publication was supported by NIH grant K12HD065987 and by the
   Mayo Clinic Center for Women's Health Research.The funding sources were
   not involved in the study design, in thecollection, analysis, and
   interpretation of the data, in writing the report, orin the decision to
   submit the paper for publication.
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   Welcome A., Medications That May Increase Weight
   Wilding JPH, 2021, NEW ENGL J MED, V384, P989, DOI 10.1056/NEJMoa2032183
NR 50
TC 5
Z9 5
U1 2
U2 7
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1072-3714
EI 1530-0374
J9 MENOPAUSE
JI Menopause-J. Menopause Soc..
PD APR
PY 2024
VL 31
IS 4
BP 266
EP 274
DI 10.1097/GME.0000000000002310
PG 9
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA LU0Q7
UT WOS:001189200900006
PM 38446869
OA hybrid
DA 2025-06-11
ER

PT J
AU Duffin, KC
   Leonardi, CL
AF Duffin, Kristina Callis
   Leonardi, Craig L.
TI Identifying and Managing Complications and Comorbidities in Patients
   With Psoriasis
SO SEMINARS IN CUTANEOUS MEDICINE AND SURGERY
LA English
DT Article
DE Biologic agents; cardiovascular disease risk factors; chronic kidney
   disease; immune-mediated inflammatory diseases; psoriasis; psoriatic
   arthritis; viral hepatitis
ID CHRONIC HEPATITIS-C; CROHNS-DISEASE; MYOCARDIAL-INFARCTION;
   RHEUMATOID-ARTHRITIS; METABOLIC SYNDROME; RISK; POPULATION; THERAPY;
   ASSOCIATION; USTEKINUMAB
AB The common comorbidities of cutaneous psoriasis include psoriatic arthritis (PsA). Crohn's disease, uveitis, and depression. In addition, cardiovascular disease risk factors (including metabolic syndrome) are seen more frequently among patients with psoriasis, and strong epidemiologic evidence has demonstrated that psoriasis is independently associated with myocardial infarction. Because these comorbid conditions and other medical complications adversely affect morbidity and mortality in patients with psoriasis, dermatologists can play an important role in promptly identifying and, when necessary, referring patients for further workup and treatment when signs or symptoms of these comorbidities or complications are observed. (C) 2015 published by Frontline Medical Communications
C1 [Duffin, Kristina Callis] Univ Utah, Dermatol, Salt Lake City, UT USA.
   [Leonardi, Craig L.] St Louis Univ, Cent Dermatol, Dermatol, St Louis, MO 63103 USA.
C3 Utah System of Higher Education; University of Utah; Saint Louis
   University
RP Leonardi, CL (corresponding author), Cent Dermatol, 1034 S Brentwood Blvd, St Louis, MO 63117 USA.
EM craig.leonardi@centralderm.com
FU AbbVie Inc.; Amgen Inc.; Celgene Corporation; Novartis Pharmaceuticals
   Corporation; AbbVie; Amgen; Bristol-Myers Squibb Company; Celgene; Eli
   Lilly and Company; Janssen Biotech, Inc.; Pfizer Inc.; Stiefel
   Laboratories, Inc.; Coherus BioSciences; Dermira Inc.; Eli Lilly;
   Galderma Laboratories, L.P.; Janssen; LEO Pharma; Merck; Novartis;
   Pfizer; Sandoz Inc.; Stiefel; Wyeth
FX Publication of this CME/CE article was jointly provided by Rutgers, The
   State University of New Jersey and Global Academy for Medical Education,
   LLC with Skin Disease Education Foundation (SDEF) and is supported by
   educational grants from AbbVie Inc., Amgen Inc., Celgene Corporation,
   and Novartis Pharmaceuticals Corporation.Kristina Callis Duffin, MD, MS,
   Grant/Research: AbbVie, Amgen, Bristol-Myers Squibb Company, Celgene,
   Eli Lilly and Company, Janssen Biotech, Inc., Pfizer Inc., and Stiefel
   Laboratories, Inc. Consultant: AbbVie, Amgen, Bristol-Myers Squibb,
   Celgene, Eli Lilly, Janssen, Novartis, Pfizer, and XenoPort, Inc.
   Scientific Advisory Board: Eli Lilly and Janssen.Craig L. Leonardi, MD,
   Grant/Research: AbbVie, Amgen, Celgene, Coherus BioSciences, Dermira
   Inc., Eli Lilly, Galderma Laboratories, L.P., Janssen, LEO Pharma,
   Merck, Novartis, Pfizer, Sandoz Inc., Stiefel, and Wyeth. Consultant:
   AbbVie, Amgen, Dermira, Eli Lilly, Janssen, LEO, Pfizer, Sandoz, and
   UCB, Inc. Speakers Bureau: AbbVie and Celgene.
CR Abdelmalek MF, 2007, AM J GASTROENTEROL, V102, P1333, DOI 10.1111/j.1572-0241.2007.01131.x
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NR 24
TC 7
Z9 7
U1 0
U2 3
PU FRONTLINE MEDICAL COMMUNICATIONS
PI THE WOODLANDS
PA WRIGHTS MEDIA, 2407 TIMBERLOCH PLACE, SUITE B, THE WOODLANDS, TX 77386
   USA
SN 1085-5629
EI 1558-0768
J9 SEMIN CUTAN MED SURG
JI Semin. Cutan. Med. Surg.
PD MAR
PY 2015
VL 34
SU 2
BP S30
EP S33
DI 10.12788/j.sder.2015.0135
PG 4
WC Dermatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology; Surgery
GA CI0JM
UT WOS:000354422900002
PM 26624961
DA 2025-06-11
ER

PT J
AU Zeb, A
   Verbrugghe, J
   Neven, A
   Burtin, C
   Janssens, L
   Meus, T
   Timmermans, A
AF Zeb, Alam
   Verbrugghe, Jonas
   Neven, An
   Burtin, Chris
   Janssens, Lotte
   Meus, Timo
   Timmermans, Annick
TI Effects of Physical Activity and Exercise Interventions on Health
   Outcomes in Occupational Drivers: A Systematic Review
SO WORKPLACE HEALTH & SAFETY
LA English
DT Review
DE occupational drivers; exercise; physical activity; rehabilitation and
   health outcomes
ID CARDIOMETABOLIC RISK-FACTORS; LONG-HAUL TRUCK; RANDOMIZED
   CONTROLLED-TRIAL; BUS DRIVERS; DISEASE; OBESITY; WEIGHT; WORK;
   OVERWEIGHT; PROGRAM
AB Background: Occupational drivers are exposed to a wide range of risk factors, including sedentary behavior and physical inactivity, which can contribute to various chronic diseases. However, exercise interventions are likely to alleviate the negative associations and reduce chronic disease risks. This systematic review aimed to inventorize research studies investigating the effects of physical activity and exercise interventions on health outcomes in occupational drivers, and to assess interventions that have demonstrated effectiveness on health outcomes in occupational drivers.Methods: The electronic databases "Web of Science," "Scopus," and "PubMed" were searched using keywords related to "occupational drivers," "exercise," and "health outcomes." Studies were included if they examined the effects of physical activity and exercise among occupational drivers on the following health outcomes: pain, disability, lifestyle factors (sleep, weight, physical activity, nutrition), fatigue, stress, and cardiometabolic risk factors. The methodological quality of the studies was assessed by the Cochrane Risk of Bias tools for randomized and non-randomized studies.Results: Fourteen articles were included (three randomized and 11 non-randomized controlled trials). All studies were judged to have an overall risk of bias as "some concerns, low, moderate or serious." Evidence suggests that stretching and isometric exercises have significantly improved pain, disability, and fatigue. In contrast, multicomponent lifestyle interventions have enhanced physical activity levels, cardiometabolic risk factors, anthropometrics (body mass index, weight, waist circumference), sleep, and dietary intake among occupational drivers.Conclusion: The available evidence indicates the potential benefits of exercise interventions and physical activity for health outcomes in occupational drivers. However, high-quality studies are needed in the future to establish stronger evidence supporting the effect of the exercise intervention.
C1 [Zeb, Alam; Verbrugghe, Jonas; Burtin, Chris; Janssens, Lotte; Meus, Timo; Timmermans, Annick] UHasselt Hasselt Univ, Fac Rehabil Sci, REVAL Rehabil Res Ctr, Agoralaan, B-3590 Diepenbeek, Belgium.
   [Neven, An] UHasselt Hasselt Univ, Transportat Res Inst IMOB, Martelarenlaan, B-3590 Diepenbeek, Belgium.
   [Burtin, Chris] UHasselt Hasselt Univ, BIOMED, Agoralaan, Diepenbeek, Belgium.
C3 Hasselt University; Hasselt University; Hasselt University
RP Zeb, A (corresponding author), UHasselt Hasselt Univ, Fac Rehabil Sci, REVAL Rehabil Res Ctr, Agoralaan, B-3590 Diepenbeek, Belgium.
EM alam.zeb@uhasselt.be
RI Neven, An/KIE-5808-2024; De Brandt, Jana/AAR-2166-2020; Janssens,
   Lotte/T-1845-2017; Zeb, Alam/JZT-0842-2024; Verbrugghe,
   Jonas/AAN-8197-2020
OI Timmermans, Annick/0000-0002-5461-947X; Zeb, Alam/0000-0003-1229-0298
FU Higher Education Commission of Pakistan (HEC)
   [HEC/HRD/OSS-III/Batch-3/Belgium/2022/19745]
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: This
   research was supported by Higher Education Commission of Pakistan (HEC),
   Grant No. HEC/HRD/OSS-III/Batch-3/Belgium/2022/19745.
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NR 63
TC 0
Z9 0
U1 3
U2 3
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 2165-0799
EI 2165-0969
J9 WORKPLACE HEALTH SAF
JI Workplace Health Saf.
PD FEB
PY 2025
VL 73
IS 2
BP 95
EP 108
DI 10.1177/21650799241291903
EA DEC 2024
PG 14
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA T9J8V
UT WOS:001380932300001
PM 39707845
DA 2025-06-11
ER

PT J
AU Farhangi, MA
   Dehghan, P
   Namazi, N
AF Farhangi, Mahdieh Abbasalizad
   Dehghan, Parvin
   Namazi, Nazli
TI Prebiotic supplementation modulates advanced glycation end-products
   (AGEs), soluble receptor for AGEs (sRAGE), and cardiometabolic risk
   factors through improving metabolic endotoxemia: a randomized-controlled
   clinical trial
SO EUROPEAN JOURNAL OF NUTRITION
LA English
DT Article
DE Prebiotic; Advanced glycation end-products; Resistant dextrin; sRAGE;
   Lipid profile; Blood pressure; Cardiovascular diseases
ID TYPE-2 DIABETES-MELLITUS; OXIDATIVE STRESS; DIETARY SUPPLEMENTATION;
   ANTIOXIDANT STATUS; RESISTANT DEXTRIN; LIPID-METABOLISM; DISEASE;
   IMPACT; WOMEN; OLIGOFRUCTOSE
AB Purpose The oxidative stress plays a key role in the initiation, propagation, and development of the complications of type 2 diabetes mellitus (T2DM). This trial aimed to evaluate the effects of resistant dextrin as a prebiotic on the cardiometabolic risk factors and the status of oxidative stress in patients with T2DM. Methods Sixty-five female subjects with T2DM were assigned to either the intervention (n = 33) or control (n = 32) groups receiving 10 g/day of resistant dextrin or placebo, respectively, for 8 weeks. Fasting blood samples were collected at baseline and post-intervention to determine the serum levels of glycemic indices, lipid profile, atherogenic indices, and soluble receptor for AGEs (sRAGE), carboxymethyl lysine (CML), pentosidine, malondialdehyde (MDA), 8-iso-prostaglandin F2 alpha (8-iso-PGF2 alpha), total antioxidant capacity (TAC), antioxidant enzymes activity, and uric acid. Data were analyzed using SPSS software 17. Paired, unpaired Student'sttests, and analysis of covariance were used to compare the quantitative variables. Results Resistant dextrin caused a significant decrease in FPG (- 17.43 mg/dl, 9.80%), TG (- 40.25 mg/dl, 23.01%), TC/HDL (- 0.80, 21.87%), LDL-c/HDL-c (- 0.80, 17.85%), Atherogenic index (- 0.40, 15.80%), LPS (- 6.5 EU/ml, 23.40%) and hs-CRP (- 8.02 ng/ml, 54.00%), MDA (- 1.21 nmol/mL, 25.58%), CML (- 93.40 ng/ml, 26.30%), 8-iso-PGF2 alpha (- 4.65 pg/ml, 15.00%), and a significant increase in TAC (0.33 mmol/L, 36.25%) and s-RAGE (2.10 ng/ml, 28.90%) in the intervention group compared with the control group. No significant changes were observed in glycosylated hemoglobin, total cholesterol, LDL-c, HDL-c, superoxide dismutase, glutathione peroxidase and catalase, pentosidine, and uric acid in the intervention group compared with the control group. Conclusions Supplementation with resistant dextrin may improve the advanced glycation end-products, sRAGE, and cardiometabolic risk factors in women with type 2 diabetes mellitus.
C1 [Farhangi, Mahdieh Abbasalizad] Tabriz Univ Med Sci, Fac Nutr, Drug Appl Res Ctr, Nutr Res Ctr, Tabriz, Iran.
   [Dehghan, Parvin] Tabriz Univ Med Sci, Fac Nutr, Nutr Res Ctr, Immunol Res Ctr, Tabriz 5166614711, Iran.
   [Namazi, Nazli] Univ Tehran Med Sci, Diabet Res Ctr, Endocrinol & Metab Clin Sci Inst, Tehran, Iran.
C3 Tabriz University of Medical Science; Tabriz University of Medical
   Science; Tehran University of Medical Sciences
RP Dehghan, P (corresponding author), Tabriz Univ Med Sci, Fac Nutr, Nutr Res Ctr, Immunol Res Ctr, Tabriz 5166614711, Iran.
EM dehghan.nut@gmail.com
RI Farhangi, Mahdieh/AAC-6758-2019; Dehghan, Parvin/G-3885-2015
OI Dehghan, Parvin/0000-0001-8929-3302
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NR 51
TC 49
Z9 49
U1 3
U2 26
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1436-6207
EI 1436-6215
J9 EUR J NUTR
JI Eur. J. Nutr.
PD OCT
PY 2020
VL 59
IS 7
BP 3009
EP 3021
DI 10.1007/s00394-019-02140-z
PG 13
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA NQ3JI
UT WOS:000570760000017
PM 31728681
DA 2025-06-11
ER

PT J
AU Arjunan, A
   Sah, DK
   Woo, M
   Song, J
AF Arjunan, Archana
   Sah, Dhiraj Kumar
   Woo, Minna
   Song, Juhyun
TI Identification of the molecular mechanism of insulin-like growth
   factor-1 (IGF-1): a promising therapeutic target for neurodegenerative
   diseases associated with metabolic syndrome
SO CELL AND BIOSCIENCE
LA English
DT Review
DE Alzheimer's disease (AD); Insulin-like growth factor-1 (IGF-1);
   Metabolic syndrome (MetS); Neurodegeneration; Neuroprotection
ID INCREASES HIPPOCAMPAL NEUROGENESIS; MILD COGNITIVE IMPAIRMENT; TYPE-2
   DIABETES-MELLITUS; FACTOR BINDING PROTEIN-3; N-TERMINAL TRIPEPTIDE;
   ALZHEIMERS-DISEASE; OXIDATIVE STRESS; INFLAMMATORY RESPONSE; RECEPTOR
   TRAFFICKING; PRECURSOR PROTEIN
AB Neurodegenerative disorders are accompanied by neuronal degeneration and glial dysfunction, resulting in cognitive, psychomotor, and behavioral impairment. Multiple factors including genetic, environmental, metabolic, and oxidant overload contribute to disease progression. Recent evidences suggest that metabolic syndrome is linked to various neurodegenerative diseases. Metabolic syndrome (MetS) is known to be accompanied by symptoms such as hyperglycemia, abdominal obesity, hypertriglyceridemia, and hypertension. Despite advances in knowledge about the pathogenesis of neurodegenerative disorders, effective treatments to combat neurodegenerative disorders caused by MetS have not been developed to date. Insulin growth factor-1 (IGF-1) deficiency has been associated with MetS-related pathologies both in-vivo and in-vitro. IGF-1 is essential for embryonic and adult neurogenesis, neuronal plasticity, neurotropism, angiogenesis, metabolic function, and protein clearance in the brain. Here, we review the evidence for the potential therapeutic effects of IGF-1 in the neurodegeneration related to metabolic syndrome. We elucidate how IGF-1 may be involved in molecular signaling defects that occurs in MetS-related neurodegenerative disorders and highlight the importance of IGF-1 as a potential therapeutic target in MetS-related neurological diseases.
C1 [Arjunan, Archana; Song, Juhyun] Chonnam Natl Univ, Dept Anat, Med Sch, Hwasun 58128, Jeollanam Do, South Korea.
   [Sah, Dhiraj Kumar] Chonnam Natl Univ, Dept Biochem, Med Sch, Hwasun 58128, South Korea.
   [Sah, Dhiraj Kumar; Song, Juhyun] Chonnam Natl Univ, BioMed Sci Grad Program BMSGP, 264 Seoyangro, Hwasun 58128, South Korea.
   [Woo, Minna] Univ Toronto, Div Endocrinol & Metab, Univ Hlth Network, Toronto, ON, Canada.
   [Woo, Minna] Univ Toronto, Banting & Best Diabet Ctr, Toronto, ON, Canada.
C3 Chonnam National University; Chonnam National University; Chonnam
   National University; University of Toronto; University Health Network
   Toronto; University of Toronto
RP Song, J (corresponding author), Chonnam Natl Univ, Dept Anat, Med Sch, Hwasun 58128, Jeollanam Do, South Korea.; Song, J (corresponding author), Chonnam Natl Univ, BioMed Sci Grad Program BMSGP, 264 Seoyangro, Hwasun 58128, South Korea.
EM juhyunsong@chonnam.ac.kr
RI Song, Juhyun/AAH-3162-2020; Woo, Minna/KOC-0684-2024
OI Song, Juhyun/0000-0002-9165-8507
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NR 218
TC 43
Z9 44
U1 2
U2 12
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 2045-3701
J9 CELL BIOSCI
JI Cell Biosci.
PD JAN 23
PY 2023
VL 13
IS 1
AR 16
DI 10.1186/s13578-023-00966-z
PG 18
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 8C5MO
UT WOS:000917652500001
PM 36691085
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Katz, JD
   Agrawal, S
   Velasquez, M
AF Katz, James D.
   Agrawal, Seema
   Velasquez, Manuel
TI Getting to the heart of the matter: osteoarthritis takes its place as
   part of the metabolic syndrome
SO CURRENT OPINION IN RHEUMATOLOGY
LA English
DT Review
DE cartilage; metabolic syndrome; osteoarthritis
ID NITRIC-OXIDE; KNEE OSTEOARTHRITIS; ARTICULAR-CARTILAGE; RADIOGRAPHIC
   OSTEOARTHRITIS; CARDIOVASCULAR SAFETY; POTENTIAL ROLE; GROWTH-FACTOR;
   RISK-FACTORS; LEPTIN; EXPRESSION
AB Purpose of review
   Labeling osteoarthritis as a degenerative arthritis is a misnomer. It is now clear that an active genetic and proteomic profile suggests inflammation. The cytokine milieu is similarly inflammatory and neatly parallels that found in the metabolic syndrome.
   Recent findings
   Important cellular changes in the osteoarthritis lesion include not only chondrocytes but also macrophages. Important catabolic mediators of osteoarthritis include metalloproteinases, a disintegrin and metalloproteinase with thrombospondin motif, a disintegrin and a metalloprotease, interleukin (IL)-1b, IL-17, IL-18 and tumor necrosis factor alpha. The striking finding that hand osteoarthritis in older women is linearly correlated to their degree of atherosclerosis suggests that a connection between osteoarthritis and atherosclerosis exists independently of putative overuse factors directly related to obesity. Therefore, it is not surprising that oxidative stress, endothelial dysfunction, and leptin dysregulation all characterize the osteoarthritis lesion. Better understanding of vitamin D metabolic effects and the Wnt, frizzled, secreted frizzled-related protein, Dickkopf, and low-density lipoprotein receptor-related protein gene families are promising regarding osteoarthritis genesis and therapeutics.
   Summary
   Current information suggests that osteoarthritis shares a similar biochemical and inflammatory profile to the metabolic syndrome. Mounting evidence exists to call attention to the fact that osteoarthritis deserves a seat at the Metabolic Syndrome 'table' of disorders.
C1 [Katz, James D.; Agrawal, Seema; Velasquez, Manuel] George Washington Univ, Div Rheumatol, Dept Med, Washington, DC 20037 USA.
C3 George Washington University
RP Katz, JD (corresponding author), George Washington Univ, Div Rheumatol, Dept Med, 3-416 2150 Penn Ave NW, Washington, DC 20037 USA.
EM jkatz@mfa.gwu.edu
RI Katz, James/ABB-8247-2020
OI Katz, James/0000-0002-2098-8883
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NR 81
TC 88
Z9 101
U1 0
U2 24
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1040-8711
EI 1531-6963
J9 CURR OPIN RHEUMATOL
JI Curr. Opin. Rheumatol.
PD SEP
PY 2010
VL 22
IS 5
BP 512
EP 519
DI 10.1097/BOR.0b013e32833bfb4b
PG 8
WC Rheumatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Rheumatology
GA 632VS
UT WOS:000280457800008
PM 20592604
DA 2025-06-11
ER

PT J
AU Greenfield, V
   Cheung, O
   Sanyal, AJ
AF Greenfield, Victoria
   Cheung, Onpan
   Sanyal, Arun J.
TI Recent advances in nonalcholic fatty liver disease
SO CURRENT OPINION IN GASTROENTEROLOGY
LA English
DT Article
DE de-novo lipogenesis; insulin resistance; metabolic syndrome;
   nonalcoholic steatohepatitis; oxidative stress
ID IMPROVES HEPATIC STEATOSIS; NONALCOHOLIC STEATOHEPATITIS;
   ADIPOSE-TISSUE; VITAMIN-E; CARDIOVASCULAR RISK; INSULIN-RESISTANCE;
   METABOLIC SYNDROME; CONTROLLED-TRIAL; GENE-EXPRESSION; GROWTH-FACTOR
AB Purpose of review
   The purpose of this review is to summarize recent advances in defining the clinical features, pathophysiology, natural history, and treatment of nonalcoholic fatty liver disease.
   Recent findings
   Nonalcoholic fatty liver disease is present in approximately 30% of the US population. A histologic grading and staging system has been developed and validated. Nonalcoholic fatty liver disease increases the risk of developing the metabolic syndrome. The presence and severity of nonalcoholic fatty liver disease correlates with the severity of obesity, fat distribution, age, and presence of other features of the metabolic syndrome. Fifteen to 20% of subjects with nonalcoholic steatohepatitis develop cirrhosis. Hepatic steatosis is associated with an increase in both free fatty acid delivery to the liver for re-esterification and increased de-novo lipogenesis. Several mechanisms of hepatocyte injury and death including free fatty acid toxicity, increased free cholesterol, cytokinemediated injury and activation of the unfolded protein response have been defined. While many therapeutic targets have been identified and pilot studies performed, a definitive treatment for nonalcoholic steatohepatitis remains to be established.
   Summary
   Nonalcoholic fatty liver disease is a widely prevalent disease that is critically linked to insulin resistance and the metabolic syndrome. While much new information on the pathogenesis and natural history of nonalcoholic steatohepatitis is available, an effective therapy remains to be established.
C1 [Greenfield, Victoria; Cheung, Onpan; Sanyal, Arun J.] Virginia Commonwealth Univ, Sch Med, Dept Internal Med, Div Gastroenterol Hepatol & Nutr, Richmond, VA 23298 USA.
C3 Virginia Commonwealth University
RP Sanyal, AJ (corresponding author), Virginia Commonwealth Univ, Sch Med, Dept Internal Med, Div Gastroenterol Hepatol & Nutr, MCV Box 980341, Richmond, VA 23298 USA.
EM ajsanyal@vcu.edu
FU NIDDK NIH HHS [K24 DK 02755-07] Funding Source: Medline
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   2004, MED SCI PARIS, V20, P758
NR 85
TC 69
Z9 86
U1 2
U2 14
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0267-1379
EI 1531-7056
J9 CURR OPIN GASTROEN
JI Curr. Opin. Gastroenterol.
PD MAY
PY 2008
VL 24
IS 3
BP 320
EP 327
DI 10.1097/MOG.0b013e3282fbccf2
PG 8
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 298SM
UT WOS:000255707400008
PM 18408460
DA 2025-06-11
ER

PT J
AU Veen, G
   Giltay, EJ
   DeRijk, RH
   van Vliet, IM
   van Pelt, J
   Zitman, FG
AF Veen, Gerthe
   Giltay, Erik J.
   DeRijk, Roel H.
   van Vliet, Irene M.
   van Pelt, Johannes
   Zitman, Frans G.
TI Salivary cortisol, serum lipids, and adiposity in patients with
   depressive and anxiety disorders
SO METABOLISM-CLINICAL AND EXPERIMENTAL
LA English
DT Article
ID CORONARY-HEART-DISEASE; CARDIOVASCULAR-DISEASE; INSULIN-RESISTANCE;
   METABOLIC SYNDROME; OBESITY; STRESS; WOMEN; RISK; GLUCOCORTICOIDS;
   DYSLIPIDEMIA
AB Depressive and anxiety disorders are associated with an increased risk of cardiovascular disease. Chronic stress induces hypothalamus-pituitary-adrenal (HPA)-axis perturbations, which might subsequently induce atherogenic lipoprotein profiles and adiposity. The aim of the present study was to investigate the relationship between basal saliva cortisol levels and serum lipids and adiposity in psychiatric patients. Eight salivary cortisol samples (awakening; 30, 45, and 60 minutes after awakening; 11:00 AM, 3:00 PM, 7:00 PM, and 11:00 PM) on 2 consecutive days in medication-free outpatients with depressive and/or anxiety disorders (n = 72) and in healthy controls (n = 42) were used to derive 2 measures of HPA-axis function: basal cortisol concentrations (ie, area under the curve [AUC(cortisol)]) and circadian cortisol variability (variability(cortisol)). Index z scores were calculated for dyslipidemia (from serum triglycerides, inverse high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol) and adiposity (from body mass index and waist-to-hip ratio). Regression analyses were conducted to determine the contribution of AUC(cortisol), and variability(cortisol) in explaining the variance of, respectively, the lipid and adiposity index. Patients showed a higher mean AUC(cortisol) compared with healthy controls (t = 2.7, P =.01). Both cortisol parameters were independently associated with dyslipidemia in patients after adjustment for age, alcohol use, and smoking habits (beta = .31, P = .02 and beta = -.29, P = .02, respectively), but not in controls. Cortisol measures were not associated with adiposity in either group. We conclude that elevated basal cortisol concentrations and lower circadian cortisol variability were independently associated with a less favorable lipoprotein profile in patients with depressive and/or anxiety disorders. These data lend support to the hypothesis that the relationship between affective disorders and cardiovascular disease is partly mediated by HPA-axis perturbations. (C) 2009 Elsevier Inc. All rights reserved.
C1 [Veen, Gerthe; Giltay, Erik J.; van Vliet, Irene M.; Zitman, Frans G.] Leiden Univ, Med Ctr, Dept Psychiat, NL-2300 RC Leiden, Netherlands.
   [DeRijk, Roel H.] Leiden Amsterdam Ctr Drug Res, Dept Med Pharmacol, NL-2300 RC Leiden, Netherlands.
   [van Pelt, Johannes] Leiden Univ, Med Ctr, Dept Clin Chem, NL-2300 RC Leiden, Netherlands.
C3 Leiden University - Excl LUMC; Leiden University; Leiden University
   Medical Center (LUMC); Leiden University; Leiden University - Excl LUMC;
   Leiden University; Leiden University Medical Center (LUMC); Leiden
   University - Excl LUMC
RP Veen, G (corresponding author), Leiden Univ, Med Ctr, Dept Psychiat, POB 9600, NL-2300 RC Leiden, Netherlands.
EM g.veen@lumc.nl
RI Zitman, Frans/E-7705-2010; Giltay, Erik/AAL-9948-2021
OI Giltay, Erik J./0000-0001-8874-2292
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NR 44
TC 35
Z9 45
U1 0
U2 10
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0026-0495
J9 METABOLISM
JI Metab.-Clin. Exp.
PD JUN
PY 2009
VL 58
IS 6
BP 821
EP 827
DI 10.1016/j.metabol.2009.02.009
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 450VU
UT WOS:000266430100012
PM 19375126
DA 2025-06-11
ER

PT J
AU Taheri, T
   Hosseindoost, S
   Kazemi, H
   Kamali, S
   Kolivand, P
   Gharaylou, Z
AF Taheri, Taher
   Hosseindoost, Saereh
   Kazemi, Hadi
   Kamali, Seyedehalia
   Kolivand, Pirhossein
   Gharaylou, Zeinab
TI Comorbidity in spinal cord injury in Iran: A narrative review
SO TRANSLATIONAL NEUROSCIENCE
LA English
DT Review
DE spinal cord injury; morbidity; Iranian patients
ID RISK-FACTORS; PRESSURE ULCERS; INDIVIDUALS; PREVALENCE; OUTCOMES;
   ANXIETY
AB Spinal cord injury (SCI) is a severe medical condition that affects millions of people worldwide each year. In Iran, an estimated 9 out of every 100,000 individuals experience traumatic SCI occurrences. Long-term disabilities and comorbidities stemming from SCI often necessitate multiple therapeutic interventions. The aim of this study is to evaluate the morbidity in Iranian SCI patients. In this study, a four-step process was used to select, extract, analyze, and synthesize relevant literature. The search covered 750 records from five databases, resulting in 25 articles included in the review. These articles, published between 2000 and 2023, utilized cross-sectional, qualitative, or cohort designs. The findings explored the prevalence, risk factors, and consequences of comorbidities associated with SCI, categorized into four themes: physical, sexual, psychological, and metabolic morbidity. Physical morbidity refers to medical conditions or complications affecting body functions or structures in SCI patients. The most frequently reported cases include pressure ulcers, pain, osteoporosis, fractures, impaired pulmonary function, renal failure, and obesity. Metabolic morbidity includes conditions such as vitamin D deficiency and cardiometabolic risk factors. Psychological morbidity encompasses depression, anxiety, and adjustment disorders. Sexual morbidity refers to conditions or complications affecting the sexual function or satisfaction of SCI patients. This narrative literature review offers a comprehensive examination of various aspects of SCI in Iranian patients. The review identifies numerous challenges and difficulties faced by SCI patients while also highlighting protective factors that can improve their well-being. Additionally, the review acknowledges gaps and limitations within the current literature and suggests possible avenues for future research.
C1 [Hosseindoost, Saereh] Univ Tehran Med Sci, Neurosci Inst, Brain & Spinal Cord Injury Res Ctr, Tehran, Iran.
   [Hosseindoost, Saereh] Univ Tehran Med Sci, Imam Khomeini Hosp Complex, Neurosci Inst, Pain Res Ctr, Tehran, Iran.
   [Taheri, Taher; Kazemi, Hadi; Kamali, Seyedehalia; Kolivand, Pirhossein; Gharaylou, Zeinab] Khatamolanbia Hosp, Shefa Neurosci Res Ctr, Tehran, Iran.
C3 Tehran University of Medical Sciences; Tehran University of Medical
   Sciences
RP Hosseindoost, S (corresponding author), Univ Tehran Med Sci, Neurosci Inst, Brain & Spinal Cord Injury Res Ctr, Tehran, Iran.; Hosseindoost, S (corresponding author), Univ Tehran Med Sci, Imam Khomeini Hosp Complex, Neurosci Inst, Pain Res Ctr, Tehran, Iran.; Gharaylou, Z (corresponding author), Khatamolanbia Hosp, Shefa Neurosci Res Ctr, Tehran, Iran.
EM s-hosseindoost@sina.tums.ac.ir; gharaylouz@yahoo.com
RI gharaylou, zeinab/O-2084-2019
OI Hosseindoost, saereh/0000-0002-9494-7558
FU Khatamolanbia Hospital Hospital
FX We thank the Khatamolanbia Hospital Hospital for its support of this
   study.
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NR 47
TC 1
Z9 1
U1 2
U2 4
PU DE GRUYTER POLAND SP Z O O
PI WARSAW
PA BOGUMILA ZUGA 32A STR, 01-811 WARSAW, MAZOVIA, POLAND
SN 2081-3856
EI 2081-6936
J9 TRANSL NEUROSCI
JI Transl. Neurosci.
PD JUL 5
PY 2024
VL 15
IS 1
AR 20220343
DI 10.1515/tnsci-2022-0343
PG 10
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA XO5M1
UT WOS:001262637900001
PM 38979518
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Kho, MC
   Lee, YJ
   Park, JH
   Cha, JD
   Choi, KM
   Kang, DG
   Lee, HS
AF Kho, Min Chul
   Lee, Yun Jung
   Park, Ji Hun
   Cha, Jeong Dan
   Choi, Kyung Min
   Kang, Dae Gill
   Lee, Ho Sub
TI Combination with Red ginseng and Polygoni Multiflori ameliorates
   highfructose diet induced metabolic syndrome
SO BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Article
DE Red ginseng; Polygoni Multiflori Radix; Metabolic syndrome; Vascular
   inflammation; Stetohepatitis
ID OXIDATIVE STRESS; OBESITY; PREVENTS; FRUCTOSE; ATHEROSCLEROSIS;
   INFLAMMATION; CHOLESTEROL; METFORMIN; EXERCISE; DISEASE
AB Background: Metabolic syndrome such as dyslipidemia, hypertension, obesity, impaired glucose tolerance and fatty liver, can be caused by modification of diet by means of overconsumption of high fructose diet. This study was designed to investigate whether combination with Red ginseng and Polygoni Multiflori Radix (RGPM), widely used traditional herbal medicine, ameliorates on highfructose (HF) diet-induced metabolic syndrome.
   Methods: SD rats were fed the 60 % HF diet with/without rosiglitazone, and RGPM 100, 300 mg/kg/day, respectively. All groups received regular diet or HF diet, respectively, for 8 weeks. The last three groups treatment of rosiglitazone and RPGM orally for a period of 6 weeks.
   Results: Chronic treatment with RGPM significantly decreased body weight, fat weight and adipocyte size. RGPM significantly prevented the development of the metabolic disturbances such as hypertension, hyperlipidemia and impaired glucose tolerance. RGPM also led to increase in high density lipoprotein level in the HF group. RGPM suppressed high-fructose diet induced vascular inflammation marker expression such as adhesion molecules and ET-1 in aorta as well as increasing of C-reactive protein (CRP) levels in plasma. Similarly, RGPM attenuated hepatic lipid accumulation by inhibition of monocyte chemoattractant protein-1 (MCP-1) expression.
   Conclusion: An administration of RGPM may be a beneficial therapy for the treatment of metabolic syndrome through the improvement of hypertension, obesity, hyperlipidemia, vascular inflammation and insulin resistance.
C1 [Kho, Min Chul; Lee, Yun Jung; Kang, Dae Gill; Lee, Ho Sub] Wonkwang Univ, Coll Oriental Med, Iksan 570749, Jeonbuk, South Korea.
   [Kho, Min Chul; Lee, Yun Jung; Kang, Dae Gill; Lee, Ho Sub] Wonkwang Univ, Profess Grad Sch Oriental Med, Iksan 570749, Jeonbuk, South Korea.
   [Kho, Min Chul; Lee, Yun Jung; Park, Ji Hun; Kang, Dae Gill; Lee, Ho Sub] Wonkwang Univ, Hanbang Body Fluid Res Ctr, Iksan 570749, Jeonbuk, South Korea.
   [Kang, Dae Gill; Lee, Ho Sub] Wonkwang Univ, Profess Grad Sch Oriental Med, Brain Korea Plus Team BK21, Iksan 570749, Jeonbuk, South Korea.
   [Cha, Jeong Dan; Choi, Kyung Min] Inst Jinan Red Ginseng, Res Dev Dept, Jinan, Peoples R China.
C3 Wonkwang University; Wonkwang University; Wonkwang University; Wonkwang
   University
RP Kang, DG; Lee, HS (corresponding author), Wonkwang Univ, Coll Oriental Med, Iksan 570749, Jeonbuk, South Korea.; Kang, DG; Lee, HS (corresponding author), Wonkwang Univ, Profess Grad Sch Oriental Med, Iksan 570749, Jeonbuk, South Korea.; Kang, DG; Lee, HS (corresponding author), Wonkwang Univ, Hanbang Body Fluid Res Ctr, Iksan 570749, Jeonbuk, South Korea.; Kang, DG; Lee, HS (corresponding author), Wonkwang Univ, Profess Grad Sch Oriental Med, Brain Korea Plus Team BK21, Iksan 570749, Jeonbuk, South Korea.
EM dgkang@wku.ac.kr; host@wku.ac.kr
FU National Research Foundation of Korea (NRF) - Korea government (MSIP)
   [2008-0062484, NRF-2015M3A9E3051054]; Ministry of Knowledge Economy
   [MKE-R0002038]
FX This work was supported by the National Research Foundation of Korea
   (NRF) grant funded by the Korea government (MSIP) (2008-0062484)
   (NRF-2015M3A9E3051054) and the Ministry of Knowledge Economy
   (MKE-R0002038).
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NR 47
TC 11
Z9 12
U1 0
U2 8
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1472-6882
J9 BMC COMPLEM ALTERN M
JI BMC Complement. Altern. Med.
PD MAR 9
PY 2016
VL 16
AR 98
DI 10.1186/s12906-016-1063-7
PG 11
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA DF9HI
UT WOS:000371671200004
PM 26961224
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Syed, IUB
AF Syed, Iffath U. B.
TI Diet, physical activity, and emotional health: what works, what doesn't,
   and why we need integrated solutions for total worker health
SO BMC PUBLIC HEALTH
LA English
DT Article
DE Immigrant health; Visible minorities; Public health; Social determinants
   of health; Total worker health
ID IMMIGRANT WOMEN WORKERS; SOCIAL DETERMINANTS; OBESITY; STRESS;
   PREVALENCE; TORONTO; CANADA; LIFE
AB Background Current research advocates lifestyle factors to manage workers' health issues, such as obesity, metabolic syndrome, and type II diabetes mellitus, among other things (World Health Organization (WHO) Obesity: preventing and managing the global epidemic, 2000; World Health Organization (WHO) Obesity and overweight, 2016), though little is known about employees' lifestyle factors in high-stress, high turnover environments, such as in the long term care (LTC) sector. Methods Drawing on qualitative single-case study in Ontario, Canada, this paper investigates an under-researched area consisting of the health practices of health care workers from high-stress, high turnover environments. In particular, it identifies LTC worker's mechanisms for maintaining physical, emotional, and social wellbeing. Results The findings suggest that while particular mechanisms were prevalent, such as through diet and exercise, they were often conducted in group settings or tied to emotional health, suggesting important social and mental health contexts to these behaviors. Furthermore, there were financial barriers that prevented workers from participating in these activities and achieving health benefits, suggesting that structurally, social determinants of health (SDoH), such as income and income distribution, are contextually important. Conclusions Accordingly, given that workplace health promotion and protection must be addressed at the individual, organizational, and structural levels, this study advocates integrated, total worker health (TWH) initiatives that consider social determinants of health approaches, recognizing the wider socio-economic impacts of workers' health and wellbeing.
C1 [Syed, Iffath U. B.] York Univ, Sch Hlth Policy & Management, Stong Coll, 3rd Floor,4700 Keele St, Toronto, ON M3J 1P3, Canada.
C3 York University - Canada
RP Syed, IUB (corresponding author), York Univ, Sch Hlth Policy & Management, Stong Coll, 3rd Floor,4700 Keele St, Toronto, ON M3J 1P3, Canada.
EM iffathsyed@yahoo.com
RI Syed, Iffath/AAH-2448-2020
OI Syed, Iffath/0000-0001-9568-3243
FU York University [n/a] Funding Source: Medline
CR [Anonymous], 2014, WORKING BODIES CHRON
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NR 52
TC 22
Z9 25
U1 0
U2 14
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2458
J9 BMC PUBLIC HEALTH
JI BMC Public Health
PD JAN 31
PY 2020
VL 20
IS 1
AR 152
DI 10.1186/s12889-020-8288-6
PG 9
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA KL6LP
UT WOS:000513533000013
PM 32005215
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU da Silva, A
   Caldas, APS
   Pinto, SL
   Hermsdorff, HHM
   Marcadenti, A
   Bersch-Ferreira, AC
   Torreglosa, CR
   Weber, B
   Bressan, J
AF da Silva, Alessandra
   Silva Caldas, Ana Paula
   Pinto, Sonia Lopes
   Hermsdorff, Helen Hermana M.
   Marcadenti, Aline
   Bersch-Ferreira, Angela Cristine
   Torreglosa, Camila Ragne
   Weber, Bernardete
   Bressan, Josefina
TI Dietary total antioxidant capacity is inversely associated with
   cardiovascular events and cardiometabolic risk factors: A
   cross-sectional study
SO NUTRITION
LA English
DT Article
DE Amputation; Antioxidants; Hypertriglyceridemic waist phenotype;
   Peripheral artery disease; Secondary care
ID OXIDATIVE STRESS; INFLAMMATION; METAANALYSIS; DISEASE; BALANCE; CANCER;
   ADULTS
AB Objectives: Dietary total antioxidant capacity (dTAC) has been introduced as a useful tool to quantify the antioxidant content of a diet. However, few studies have evaluated the association of dTAC with cardiovascular disease (CVD) occurrence and cardiometabolic risk factors in people with established CVD events. Thus, we aimed to investigate the presence of an association between dTAC values, cardiovascular events, and cardiometabolic risk factors in individuals with previous CVD in a Brazilian multicenter study. Methods: This study has a cross-sectional design. We evaluated baseline data from the Brazilian Cardioprotective Nutritional Program Trial. Sociodemographic, anthropometric, clinical, and food-consumption data were collected in face-to-face interviews. We estimated dTAC from the mean of two 24-h dietary recalls by values of ferric-reducing antioxidant power. Results: We evaluated 2346 participants, most of whom were men (58.4%), older adults (64.2%), and overweight (68.6%), and had coronary artery disease (92.4%). The mean dTAC was equal to 5.6 (interquartile range, 3.9-7.8) mmol/1000 kcal. Participants in the third dTAC tertile (9.2 mmol/1000 kcal) had a 22%, 59%, and 69% lower chance, respectively, of having hypertriglyceridemic waist phenotype, abdominal aortic aneurysm, and amputation due to arterial disease in comparison to the first tertile (3.4 mmol/1000 kcal). Conclusions: The dTAC was inversely associated with hypertriglyceridemic waist phenotype, abdominal aortic aneurysm, and amputation due to arterial disease in individuals undergoing secondary care for CVD. Our results can guide strategies for the prevention of new CVD and its consequences. (c) 2021 Elsevier Inc. All rights reserved.
C1 [da Silva, Alessandra; Silva Caldas, Ana Paula; Hermsdorff, Helen Hermana M.; Bressan, Josefina] Univ Fed Vicosa, Dept Nutr & Hlth, Lab Energy Metab & Body Composit, Vicosa, MG, Brazil.
   [Pinto, Sonia Lopes] Univ Fed Tocantins, Palmas, Tocantins, Brazil.
   [Marcadenti, Aline; Bersch-Ferreira, Angela Cristine; Torreglosa, Camila Ragne; Weber, Bernardete] Hosp Coracao IP HCor, HCor Res Inst, Sao Paulo, Brazil.
   [Marcadenti, Aline] Inst Cardiol Rio Grande do Sul IC FUC, Grad Program Hlth Sci Cardiol, Porto Alegre, RS, Brazil.
C3 Universidade Federal de Vicosa; Universidade Federal do Tocantins (UFT);
   Hospital do Coracao - HCor; Fundacao Universitaria de Cardiologia
RP da Silva, A; Bressan, J (corresponding author), Univ Fed Vicosa, Dept Nutr & Hlth, Lab Energy Metab & Body Composit, Vicosa, MG, Brazil.
EM alessan.drasg94@gmail.com; jbrm@ufv.br
RI Bressan, Josefina/A-2598-2009; Bersch-Ferreira, Angela/JCD-9807-2023;
   Marcadenti, Aline/A-8085-2012; Caldas, Ana Paula/E-8411-2017
OI Silva Caldas, Ana Paula/0000-0002-7517-3323; da Silva,
   Alessandra/0000-0002-4188-2586; Bersch-Ferreira,
   Angela/0000-0003-3478-781X
FU Hospital do Coracao (HCor),"Hospitais de Excelencia a Servico do SUS
   (PROADI-SUS)" Program; Brazilian Ministry of Health; Coordenacao de
   Aperfeicoamento de Pessoal de Nivel Superior (CAPES) [001]
FX This work was supported by Hospital do Coracao (HCor) as part of the
   "Hospitais de Excelencia a Servico do SUS (PROADI-SUS)" Program, in
   partnership with the Brazilian Ministry of Health. J.B. and H.H.M.H. are
   CNPq Researcher Fellows. A.S. and A.P.S.C. received scholarship from
   Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES, Code
   001).
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NR 50
TC 9
Z9 9
U1 1
U2 5
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0899-9007
EI 1873-1244
J9 NUTRITION
JI Nutrition
PD SEP
PY 2021
VL 89
AR 111140
DI 10.1016/j.nut.2021.111140
EA APR 2021
PG 7
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA UJ4VA
UT WOS:000691283500020
PM 33838491
OA Bronze
DA 2025-06-11
ER

EF﻿FN Clarivate Analytics Web of Science
VR 1.0
PT J
AU Trehan, S
   Singh, G
   Singh, A
   Bector, G
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   Antil, P
   Kalpana, F
   Farooq, A
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AF Trehan, Shubam
   Singh, Gurjot
   Singh, Adarshpreet
   Bector, Gaurav
   Jain, Aayush
   Antil, Priya
   Kalpana, Fnu
   Farooq, Amna
   Singh, Harmandeep
TI Chemotherapy and Metabolic Syndrome: A Comprehensive Review of Molecular
   Pathways and Clinical Outcomes
SO CUREUS JOURNAL OF MEDICAL SCIENCE
LA English
DT Article
DE preventive strategies; cancer therapy; cardiovascular diseases;
   metabolic syndrome; chemotherapy
ID LONG-TERM SURVIVORS; CANCER; CHILDHOOD; RISK; THERAPY
AB Cancer therapies, notably chemotherapy, have significantly improved survival rates and quality of life for many patients. However, chemotherapy's cytotoxic effects also impact normal cells, leading to adverse effects, including metabolic disturbances. This paper explores the link between chemotherapy and metabolic syndrome, a cluster of metabolic abnormalities that increase the risk of cardiovascular diseases and type 2 diabetes. Understanding the predictors, such as specific chemotherapy regimens, patient characteristics, comorbid conditions, lifestyle factors, and genetic variations, is crucial for formulating personalized care plans and preventive strategies. Research indicates that older age, female gender, pre-existing diabetes, and baseline obesity are significant predictors of metabolic syndrome in cancer patients. Chemotherapy-induced molecular changes, including insulin resistance, dyslipidemia, chronic inflammation, oxidative stress, and tissue fibrosis, contribute to the development of this syndrome. Effective management strategies require a multidisciplinary approach, incorporating lifestyle interventions, pharmacological treatments, and regular monitoring. This paper underscores the importance of personalized medicine in mitigating the risks associated with metabolic syndrome and improving long-term health outcomes for cancer survivors. Future research directions include longitudinal studies to track metabolic health over time, mechanistic studies to uncover the molecular pathways involved, and the development of integrative therapies. By adopting comprehensive care models, healthcare providers can enhance the overall quality of life for cancer survivors, addressing both cancer and metabolic health challenges.
C1 [Trehan, Shubam; Singh, Adarshpreet; Bector, Gaurav; Jain, Aayush; Antil, Priya; Kalpana, Fnu; Farooq, Amna; Singh, Harmandeep] Yale New Haven Hosp, Internal Med, New Haven, CT USA.
   [Singh, Gurjot] Yale Sch Med, Internal Med, New Haven, CT 06510 USA.
   [Singh, Harmandeep] Waterbury Hosp & Hlth Ctr, Yale Waterbury Internal Med Residency Program, Internal Med, Waterbury, CT USA.
C3 Yale University; Yale University
RP Singh, G (corresponding author), Yale Sch Med, Internal Med, New Haven, CT 06510 USA.
EM gurjot.js.25@gmail.com
OI Antil, Priya/0000-0003-1888-3385
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NR 38
TC 0
Z9 0
U1 1
U2 2
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
EI 2168-8184
J9 CUREUS J MED SCIENCE
JI Cureus J Med Sci
PD AUG 7
PY 2024
VL 16
IS 8
AR e66354
DI 10.7759/cureus.66354
PG 11
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA C3O5O
UT WOS:001288482800007
PM 39246917
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Makowski, L
   Hotamisligil, GS
AF Makowski, L
   Hotamisligil, GS
TI Fatty acid binding proteins - The evolutionary crossroads of
   inflammatory and metabolic responses
SO JOURNAL OF NUTRITION
LA English
DT Article; Proceedings Paper
CT Symposium on Nutrition and Gene Regulation
CY 2003
CL Harvard Med Sch, Boston, MA
HO Harvard Med Sch
DE fatty acid binding protein (FABP); Metabolic Syndrome; inflammation;
   obesity; insulin resistance
ID PROLIFERATOR-ACTIVATED RECEPTORS; INDUCED INSULIN-RESISTANCE; HUMAN
   THP-1 MACROPHAGES; KAPPA-B KINASE; MICE LACKING; LIPID-METABOLISM;
   PPAR-GAMMA; GENE; AP2; ATHEROSCLEROSIS
AB Fatty acid binding proteins (FABPs) are members of a highly conserved family of proteins with the task of protecting a cell's delicate lipid balance. Yet they fail when faced with metabolic or inflammatory stress, turning the cytosol into an inhospitable environment with less than ideal outcomes. This review will focus on how FABPs direct lipid traffic and simultaneously control inflammatory and metabolic pathways under the pressures of the Metabolic Syndrome.
C1 Harvard Univ, Sch Publ Hlth, Dept Genet & Complex Dis, Boston, MA USA.
C3 Harvard University; Harvard T.H. Chan School of Public Health
RP Harvard Univ, Sch Publ Hlth, Dept Genet & Complex Dis, Boston, MA USA.
EM ghotamis@hsph.harvard.edu
RI Makowski, Liza/B-8062-2012; Hotamisligil, Gokhan/ABL-2919-2022
OI Makowski, Liza/0000-0002-5337-8037
FU NHLBI NIH HHS [F32 HL075970] Funding Source: Medline
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NR 56
TC 230
Z9 260
U1 0
U2 12
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0022-3166
EI 1541-6100
J9 J NUTR
JI J. Nutr.
PD SEP
PY 2004
VL 134
IS 9
BP 2464S
EP 2468S
DI 10.1093/jn/134.9.2464S
PG 5
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Nutrition & Dietetics
GA 852KE
UT WOS:000223753400044
PM 15333743
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Lucini, D
   Malacarne, M
   Gatzemeier, W
   Pagani, M
AF Lucini, Daniela
   Malacarne, Mara
   Gatzemeier, Wolfgang
   Pagani, Massimo
TI A Simple Home-Based Lifestyle Intervention Program to Improve Cardiac
   Autonomic Regulation in Patients with Increased Cardiometabolic Risk
SO SUSTAINABILITY
LA English
DT Article
DE autonomic nervous system; prevention; exercise; home-based intervention;
   nutrition; heart rate variability
ID HEART-RATE-VARIABILITY; PHYSICAL-ACTIVITY; EXERCISE; DISEASE;
   REHABILITATION; ASSOCIATION; BAROREFLEX; PREVENTION; REDUCTION; MEDICINE
AB Lifestyle modification programs (LMP) represent a new approach to cardiometabolic/oncologic risk reduction. Successful LMP in clinical practice must be feasible, cost effective, efficacious and consider home-based exercise. Likewise, multiple mechanisms implied in cardiometabolic risk reduction such as cardiac autonomic regulation (CAR) should be easily evidenced, in spite of the computational complexity involved. This goal could be facilitated by employing novel, friendlier, simpler techniques, such as the Autonomic Nervous System Index (ANSI), which can be treated as a proxy of CAR. In this observational study, we introduce a simple LMP (based on cognitive behavioral strategies and patient-tailored prescription of nutrition and home-based exercise, managed by a single physician) into the currently existing clinical practice of secondary cardiometabolic prevention. In 26 subjects, we assessed CAR (autoregressive spectral analysis of cardiovascular variabilities), body mass composition (bioelectrical impedance analysis) and stress perception (questionnaires). After LMP, ANSI and lipid profile were improved; % of fat mass, waist circumference and stress perception were reduced. We conclude that this preliminary, proof of concept study provides significant evidence in favor of the hypothesis that it is possible to introduce a convenient, cost effective LMP into the currently existing clinical practice of secondary cardiometabolic prevention. Findings suggest a successful comprehensive behavioral change, possibly facilitated by the simplified approach employed in this study, capable of improving cardiac autonomic regulation in addition to body mass composition and stress perception.
C1 [Lucini, Daniela; Malacarne, Mara; Pagani, Massimo] Univ Milan, BIOMETRA Dept, I-20122 Milan, Italy.
   [Lucini, Daniela; Malacarne, Mara] Humanitas Clin & Res Ctr, Exercise Med Unit, I-20089 Rozzano, Italy.
   [Gatzemeier, Wolfgang] Humanitas Clin & Res Ctr, Canc Ctr, I-20089 Rozzano, Italy.
C3 University of Milan; IRCCS Humanitas Research Hospital; IRCCS Humanitas
   Research Hospital
RP Lucini, D (corresponding author), Univ Milan, BIOMETRA Dept, I-20122 Milan, Italy.; Lucini, D (corresponding author), Humanitas Clin & Res Ctr, Exercise Med Unit, I-20089 Rozzano, Italy.
EM daniela.lucini@unimi.it; mara.malacarne@unimi.it;
   wolfgang.gatzemeier@humanitas.it; Massimo.paganiz@gmail.com
RI lucini, daniela/ABD-7517-2021; Gatzemeier, Wolfgang/HMV-2117-2023
OI Gatzemeier, Wolfgang/0000-0002-4026-0283
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NR 47
TC 15
Z9 15
U1 0
U2 2
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2071-1050
J9 SUSTAINABILITY-BASEL
JI Sustainability
PD SEP
PY 2020
VL 12
IS 18
AR 7671
DI 10.3390/su12187671
PG 12
WC Green & Sustainable Science & Technology; Environmental Sciences;
   Environmental Studies
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Science & Technology - Other Topics; Environmental Sciences & Ecology
GA OJ9HQ
UT WOS:000584265700001
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Schäfer, I
   Kaduszkiewicz, H
   Wagner, HO
   Schön, G
   Scherer, M
   van den Bussche, H
AF Schaefer, Ingmar
   Kaduszkiewicz, Hanna
   Wagner, Hans-Otto
   Schoen, Gerhard
   Scherer, Martin
   van den Bussche, Hendrik
TI Reducing complexity: a visualisation of multimorbidity by combining
   disease clusters and triads
SO BMC PUBLIC HEALTH
LA English
DT Article
DE Multimorbidity; Multimorbidity patterns; Disease combinations;
   Epidemiology; Chronic diseases; Elderly people; Factor analysis; Network
   analysis; Observed-expected-ratios; Claims data set
ID LOW-BACK-PAIN; PATTERNS; PREVALENCE; HEALTH; RISK; OSTEOARTHRITIS;
   HYPERTENSION; COMORBIDITY; DEFINITION; DEPRESSION
AB Background: Multimorbidity is highly prevalent in the elderly and relates to many adverse outcomes, such as higher mortality, increased disability and functional decline. Many studies tried to reduce the heterogeneity of multimorbidity by identifying multimorbidity clusters or disease combinations, however, the internal structure of multimorbidity clusters and the linking between disease combinations and clusters are still unknown. The aim of this study was to depict which diseases were associated with each other on person-level within the clusters and which ones were responsible for overlapping multimorbidity clusters.
   Methods: The study analyses insurance claims data of the Gmunder ErsatzKasse from 2006 with 43,632 female and 54,987 male patients who were 65 years and older. The analyses are based on multimorbidity clusters from a previous study and combinations of three diseases ("triads") identified by observed/expected ratios >= 2 and prevalence rates >= 1%. In order to visualise a "disease network", an edgelist was extracted from these triads, which was analysed by network analysis and graphically linked to multimorbidity clusters.
   Results: We found 57 relevant triads consisting of 31 chronic conditions with 200 disease associations ("edges") in females and 51 triads of 29 diseases with 174 edges in males. In the disease network, the cluster of cardiovascular and metabolic disorders comprised 12 of these conditions in females and 14 in males. The cluster of anxiety, depression, somatoform disorders, and pain consisted of 15 conditions in females and 12 in males.
   Conclusions: We were able to show which diseases were associated with each other in our data set, to which clusters the diseases were assigned, and which diseases were responsible for overlapping clusters. The disease with the highest number of associations, and the most important mediator between diseases, was chronic low back pain. In females, depression was also associated with many other diseases. We found a multitude of associations between disorders of the metabolic syndrome of which hypertension was the most central disease. The most prominent bridges were between the metabolic syndrome and musculoskeletal disorders. Guideline developers might find our approach useful as a basis for discussing which comorbidity should be addressed.
C1 [Schaefer, Ingmar; Kaduszkiewicz, Hanna; Wagner, Hans-Otto; Scherer, Martin; van den Bussche, Hendrik] Univ Med Ctr Hamburg Eppendorf, Dept Primary Med Care, D-20246 Hamburg, Germany.
   [Kaduszkiewicz, Hanna] Univ Kiel, Fac Med, Inst Gen Practice, Kiel, Germany.
   [Schoen, Gerhard] Univ Med Ctr Hamburg Eppendorf, Dept Med Biometry & Epidemiol, D-20246 Hamburg, Germany.
C3 University of Hamburg; University Medical Center Hamburg-Eppendorf;
   University of Kiel; University of Hamburg; University Medical Center
   Hamburg-Eppendorf
RP Schäfer, I (corresponding author), Univ Med Ctr Hamburg Eppendorf, Dept Primary Med Care, Martinistr 52, D-20246 Hamburg, Germany.
EM in.schaefer@uke.de
FU German Federal Ministry of Education and Research [01ET0725, 01ET0731,
   01ET1006A-K]
FX We thank the health insurance company BARMER/GEK for providing the data.
   The study was funded by the German Federal Ministry of Education and
   Research (http://www.bmbf.bund.de/; grant numbers 01ET0725, 01ET0731 and
   01ET1006A-K). The funders had no role in study design, data collection
   and analysis, decision to publish or preparation of the manuscript.
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NR 34
TC 73
Z9 82
U1 1
U2 23
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2458
J9 BMC PUBLIC HEALTH
JI BMC Public Health
PD DEC 16
PY 2014
VL 14
AR 1285
DI 10.1186/1471-2458-14-1285
PG 14
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA CA0KY
UT WOS:000348607800001
PM 25516155
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Shubair, MM
   McCrory, C
   Reschny, J
   Tobin, P
AF Shubair, Mamdouh M.
   McCrory, Cassondra
   Reschny, Jamie
   Tobin, Pamela
TI ELDERLY MEN AND HEALTH SERVICE PROVISION FOR TYPE 2 DIABETES MANAGEMENT:
   SYNTHESIS OF KNOWLEDGE GAPS AND IDENTIFICATION OF RESEARCH NEEDS
SO JOURNAL OF MENS HEALTH
LA English
DT Article
DE Men's health, elderly; type 2 diabetes; patient-oriented care; health
   services; hypoglycemia; polypharmacy
ID COMPLICATIONS; DISEASES
AB Chronic long-standing type 2 diabetes and subsequent complications (comorbidities) represent a major clinical and public health challenge for elderly men from a prevention and management viewpoint. In the developed western countries, evidence suggests that 80% of premature deaths and disability due to diabetes and heart disease can be prevented. Diabetes care in the elderly include further challenges in management of comorbidities such as hypertension, the metabolic syndrome (MetS), kidney problems including nephropathy and chronic renal failure, vision abnormalities such as cataract and retinopathy. The comorbidities are subsequent to complex mechanistic processes incurred by the hyperglycemia and reduced insulin sensitivity in diabetes. Management of diabetic elderly patients with type 2 diabetes is further challenged by lack of specific clinical guidelines tailored to this population. Existing clinical guidelines are based on evidence from clinical trials conducted in younger (< 65 years of age) patients. There is a need for designing improved models of health care delivery, assessment of comorbidities and polypharmacy in elderly men, including mental health issues such as depression and dementia that may persist with diabetes. An integrated, comprehensive, and patient-oriented management care plan seems the best practice clinical approach to ensure that the risk of hypoglycemia does not increase while treating elderly diabetic men with existent multimorbidity.
C1 [Shubair, Mamdouh M.; Reschny, Jamie] Univ Northern British Columbia UNBC, Prince George, BC, Canada.
   [McCrory, Cassondra] Univ Waterloo, Waterloo, ON, Canada.
   [Tobin, Pamela] Canadian Partnership Canc, Toronto, ON, Canada.
C3 University of Waterloo
RP Shubair, MM (corresponding author), Univ Northern British Columbia UNBC, Prince George, BC, Canada.
EM mamdouh.shubair@unbc.ca
OI Shubair, Mamdouh/0000-0003-4758-072X
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NR 19
TC 2
Z9 2
U1 0
U2 4
PU DOUGMAR PUBLISHING GROUP INC
PI HAMILTON
PA 1 HUNTER ST E STE G-100, HAMILTON, ONTARIO L8N-3W1, CANADA
SN 1875-6859
J9 J MENS HEALTH
JI J. Mens Health
PY 2018
VL 14
IS 3
BP E77
EP E83
DI 10.22374/1875-6859.14.3.11
PG 7
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA HJ3DM
UT WOS:000457049800011
OA gold
DA 2025-06-11
ER

PT J
AU Dimopoulou, AE
   Vassilakis, KD
   Fragoulis, GE
AF Dimopoulou, Angeliki E.
   Vassilakis, Konstantinos D.
   Fragoulis, George E.
TI Difficult to Treat Psoriatic Arthritis: The Road So Far
SO MEDITERRANEAN JOURNAL OF RHEUMATOLOGY
LA English
DT Article
DE psoriatic arthritis; difficult to treat; comorbidities; bDMARDS
ID DISEASE
AB Psoriatic Arthritis (PsA) is a multifaceted, immune-mediated disease marked by chronic musculoskeletal inflammation (peripheral arthritis and axial disease, dactylitis, and enthesitis), extra-musculoskeletal manifestations (psoriasis, nail involvement, Inflammatory Bowel Disease [IBD], and uveitis) and multi-comorbidity (cardiovascular disease, metabolic syndrome, mental health disorders, and fibromyalgia). Immunological and non-immunological factors have led, despite the progress made in the understanding, treatment and management of PsA, to a minority of patients being able to achieve satisfactory outcomes. Following the establishment of the definition for difficult to treat rheumatoid arthritis, efforts are underway for difficult to treat PsA (D2T PsA). Defining D2T PsA and its predictors is crucial for advancing clinical trials, treatment strategies, and patient care. Proposed definitions and criteria for D2T PsA vary, but the few available data indicate that extensive psoriasis, axial involvement, obesity, female gender, and comorbidities like IBD, depression, and fibromyalgia are involved. Concerns are also raised for the lack of a universally accepted index for disease activity measurement and for the inclusion of a time-related criterion in the definition of D2T. Moreover, the potential need for distinction between D2T and refractory-to-treatment PsA has also been suggested. In this narrative review, we summarise the current knowledge on the D2T PsA field, highlighting the gaps and the necessity of the "D2T" concept, providing further considerations on the matter.
C1 [Dimopoulou, Angeliki E.; Vassilakis, Konstantinos D.; Fragoulis, George E.] Natl & Kapodistrian Univ Athens, Dept Propaedeut & Internal Med 1, Joint Acad Rheumatol Programme, 17 Ag Thoma Str, Athens 11527, Greece.
C3 National & Kapodistrian University of Athens
RP Fragoulis, GE (corresponding author), Natl & Kapodistrian Univ Athens, Dept Propaedeut & Internal Med 1, Joint Acad Rheumatol Programme, 17 Ag Thoma Str, Athens 11527, Greece.
EM geofragoul@yahoo.gr
CR Azuaga AB, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms24054901
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NR 22
TC 0
Z9 0
U1 1
U2 1
PU GREEK RHEUMATOLOGY SOC & PROFESSIONAL ASSOC RHEUMATOLOGISTS
PI Athens
PA 387 Mesogeion Str, Athens, GREECE
SN 2529-198X
J9 MEDITERR J RHEUMATOL
JI Mediterr. J. Rheumatol.
PD DEC
PY 2024
VL 35
SU 3
DI 10.31138/mjr.2506241.dtt
PG 7
WC Rheumatology
WE Emerging Sources Citation Index (ESCI)
SC Rheumatology
GA 0HE2J
UT WOS:001447273000002
PM 39974588
OA gold
DA 2025-06-11
ER

PT J
AU Ezrokhi, M
   Zhang, YH
   Luo, SQ
   Cincotta, AH
AF Ezrokhi, Michael
   Zhang, Yahong
   Luo, Shuqin
   Cincotta, Anthony H.
TI Time-of-Day-Dependent Effects of Bromocriptine to Ameliorate Vascular
   Pathology and Metabolic Syndrome in SHR Rats Held on High Fat Diet
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE circadian; neuroendocrine; resetting; bromocriptine; dopamine; diabetes;
   insulin resistance; metabolic; vascular
ID NITRIC-OXIDE SYNTHASE; ENDOTHELIAL NO SYNTHASE; CARDIOVASCULAR-DISEASE
   RISK; HYPOTHALAMIC NEUROPEPTIDE-Y; PERIPHERAL CLOCK DISORDERS;
   RESISTANCE-RELATED INDEXES; HYDROGEN-PEROXIDE; GENE-EXPRESSION; INSULIN
   SENSITIVITY; SMOOTH-MUSCLE
AB The treatment of type 2 diabetes patients with bromocriptine-QR, a unique, quick release micronized formulation of bromocriptine, improves glycemic control and reduces adverse cardiovascular events. While the improvement of glycemic control is largely the result of improved postprandial hepatic glucose metabolism and insulin action, the mechanisms underlying the drug's cardioprotective effects are less well defined. Bromocriptine is a sympatholytic dopamine agonist and reduces the elevated sympathetic tone, characteristic of metabolic syndrome and type 2 diabetes, which potentiates elevations of vascular oxidative/nitrosative stress, known to precipitate cardiovascular disease. Therefore, this study investigated the impact of bromocriptine treatment upon biomarkers of vascular oxidative/nitrosative stress (including the pro-oxidative/nitrosative stress enzymes of NADPH oxidase 4, inducible nitric oxide (iNOS), uncoupled endothelial nitric oxide synthase (eNOS), the pro-inflammatory/pro-oxidative marker GTP cyclohydrolase 1 (GTPCH 1), and the pro-vascular health enzyme, soluble guanylate cyclase (sGC) as well as the plasma level of thiobarbituric acid reactive substances (TBARS), a circulating marker of systemic oxidative stress), in hypertensive SHR rats held on a high fat diet to induce metabolic syndrome. Inasmuch as the central nervous system (CNS) dopaminergic activities both regulate and are regulated by CNS circadian pacemaker circuitry, this study also investigated the time-of-day-dependent effects of bromocriptine treatment (10 mg/kg/day at either 13 or 19 h after the onset of light (at the natural waking time or late during the activity period, respectively) among animals held on 14 h daily photoperiods for 16 days upon such vascular biomarkers of vascular redox state, several metabolic syndrome parameters, and mediobasal hypothalamic (MBH) mRNA expression levels of neuropeptides neuropeptide Y (NPY) and agouti-related protein (AgRP) which regulate the peripheral fuel metabolism and of mRNA expression of other MBH glial and neuronal cell genes that support such metabolism regulating neurons in this model system. Such bromocriptine treatment at ZT 13 improved (reduced) biomarkers of vascular oxidative/nitrosative stress including plasma TBARS level, aortic NADPH oxidase 4, iNOS and GTPCH 1 levels, and improved other markers of coupled eNOS function, including increased sGC protein level, relative to controls. However, bromocriptine treatment at ZT 19 produced no improvement in either coupled eNOS function or sGC protein level. Moreover, such ZT 13 bromocriptine treatment reduced several metabolic syndrome parameters including fasting insulin and leptin levels, as well as elevated systolic and diastolic blood pressure, insulin resistance, body fat store levels and liver fat content, however, such effects of ZT 19 bromocriptine treatment were largely absent versus control. Finally, ZT 13 bromocriptine treatment reduced MBH NPY and AgRP mRNA levels and mRNA levels of several MBH glial cell/neuronal genes that code for neuronal support/plasticity proteins (suggesting a shift in neuronal structure/function to a new metabolic control state) while ZT 19 treatment reduced only AgRP, not NPY, and was with very little effect on such MBH glial cell genes expression.
   These findings indicate that circadian-timed bromocriptine administration at the natural circadian peak of CNS dopaminergic activity (that is diminished in insulin resistant states), but not outside this daily time window when such CNS dopaminergic activity is naturally low, produces widespread improvements in biomarkers of vascular oxidative stress that are associated with the amelioration of metabolic syndrome and reductions in MBH neuropeptides and gene expressions known to facilitate metabolic syndrome. These results of such circadian-timed bromocriptine treatment upon vascular pathology provide potential mechanisms for the observed marked reductions in adverse cardiovascular events with circadian-timed bromocriptine-QR therapy (similarly timed to the onset of daily waking as in this study) of type 2 diabetes subjects and warrant further investigations into related mechanisms and the potential application of such intervention to prediabetes and metabolic syndrome patients as well.
C1 [Ezrokhi, Michael; Zhang, Yahong; Luo, Shuqin; Cincotta, Anthony H.] VeroSci LLC, Tiverton, RI 02878 USA.
RP Cincotta, AH (corresponding author), VeroSci LLC, Tiverton, RI 02878 USA.
EM Michael_Ezrokhi@veroscience.com; Yahong_Zhang@veroscience.com;
   Shuqin_Luo@veroscience.com; Anthony_Cincotta@veroscience.com
RI Zhang, Yahong/B-9922-2014; Ezrokhi, Michael/IRZ-4665-2023
OI Cincotta, Anthony/0000-0002-8329-3341
FU VeroScience LLC
FX This research was funded by VeroScience LLC.
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NR 154
TC 8
Z9 8
U1 2
U2 4
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD JUN
PY 2021
VL 22
IS 11
AR 6142
DI 10.3390/ijms22116142
PG 23
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA SQ2YD
UT WOS:000660222100001
PM 34200262
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Sookoian, S
   Gemma, C
   Garcia, SI
   Gianotti, TF
   Dieuzeide, G
   Roussos, A
   Tionietti, M
   Trifone, L
   Kanevsky, D
   González, CD
   Pirola, CJ
AF Sookoian, Silvia
   Gemma, Carolina
   Garcia, Silvia I.
   Gianotti, Tomas Fernandez
   Dieuzeide, Guillermo
   Roussos, Adriana
   Tionietti, Miriam
   Trifone, Liliana
   Kanevsky, Diego
   Gonzalez, Claudio D.
   Pirola, Carlos J.
TI Short allele of serotonin transporter gene promoter is a risk factor for
   obesity in adolescents
SO OBESITY
LA English
DT Article
DE adolescents; SLC6A4; polymorphism; serotonin; serotonin transporter
ID METABOLIC SYNDROME; BRAIN-SEROTONIN; ASSOCIATION; DEPRESSION;
   POLYMORPHISM; CHILDHOOD; BEHAVIOR; ANXIETY
AB Obesity and hypertension are increasing medical problems in adolescents. Serotonin transporter (5-HTT) is involved in mood and eating disturbances. Encoded by the gene SLC6A4, the promoter shows functional insertion/deletion alleles: long (L) and short (S). Because individuals who are 'carriers for the short version are known to be at risk for higher levels of anxiety, we hypothesized that this variant may be associated with overweight. Data and blood samples were collected from 172 adolescents out of a cross-sectional, population-based study of 934 high school students. To replicate the findings, we also included 119 outpatients from the Nutrition and Diabetes Section of the Children's County Hospital. We found that the S allele was associated with overweight (BMI > 85th percentile), being a risk factor for overweight independently of sex, age, and hypertension [odds ratio (OR): 1.85; 95% confidence interval (CI): 1.13, 3.05; p < 0.02]. Additionally, in the outpatient study, compared with the homozygous LL subjects, S allele carriers showed a higher BMI z-score (1.47 +/- 1.09 vs. 0.51 +/- 1.4; p < 0.002) and were more frequent in overweight children. In conclusion, the S allele of the SLC6A4 promoter variant is associated with overweight being an independent genetic risk factor for obesity.
C1 Univ Buenos Aires, Med Res Inst, Buenos Aires, DF, Argentina.
   CAIDEM, Chacabuco, Argentina.
   Childrens Hosp Dr Ricardo Gutierrez, Diabet & Nutr Sect, Buenos Aires, DF, Argentina.
   Univ Buenos Aires, Sch Med, Dept Pharmacol, RA-1053 Buenos Aires, DF, Argentina.
   Univ Buenos Aires, Sch Pharm & Biochem, RA-1053 Buenos Aires, DF, Argentina.
C3 University of Buenos Aires; Hospital de Ninos Doctor Ricardo Gutierrez;
   University of Buenos Aires; University of Buenos Aires
RP Pirola, CJ (corresponding author), Inst Invest Med A Lanari, Combatientes De Malvinas 3150, RA-1427 Buenos Aires, DF, Argentina.
EM pirola.carlos@lanari.fmed.uba.ar
RI Pirola, Carlos/H-2720-2019
OI Gonzalez, Claudio/0000-0002-3772-8850; Pirola, Carlos
   Jose/0000-0001-8234-4058; Fernandez Gianotti, Tomas/0000-0003-2569-9156;
   Gemma, Carolina/0000-0002-4890-9972
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NR 24
TC 64
Z9 71
U1 0
U2 8
PU NORTH AMER ASSOC STUDY OBESITY
PI SILVER SPRING
PA 8630 FENTON ST, SUITE 918, SILVER SPRING, MD 20910 USA
SN 1930-7381
J9 OBESITY
JI Obesity
PD FEB
PY 2007
VL 15
IS 2
BP 271
EP 276
DI 10.1038/oby.2007.519
PG 6
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 212OB
UT WOS:000249605600001
PM 17299098
DA 2025-06-11
ER

PT J
AU Galilea-Zabalza, I
   Buil-Cosiales, P
   Salas-Salvadó, J
   Toledo, E
   Ortega-Azorín, C
   Díez-Espino, J
   Vázquez-Ruiz, Z
   Zomeño, MD
   Vioque, J
   Martínez, JA
   Romaguera, D
   Perez-Farinos, N
   López-Miranda, J
   Estruch, R
   Bueno-Cavanillas, A
   Arós, F
   Tur, JA
   Tinahones, F
   Serra-Majem, L
   Marcos-Delgado, A
   Ortega-Calvo, M
   Vázquez, C
   Pintó, X
   Vidal, J
   Daimiel, L
   Delgado-Rodríguez, M
   Matía, P
   Corella, D
   Diaz-López, A
   Babio, N
   Muñoz, MA
   Fitó, M
   González-Palacios, S
   Abete, I
   García-Rios, A
   Ros, E
   Martínez-González, MA
AF Galilea-Zabalza, Inigo
   Buil-Cosiales, Pilar
   Salas-Salvado, Jordi
   Toledo, Estefania
   Ortega-Azorin, Carolina
   Diez-Espino, Javier
   Vazquez-Ruiz, Zenaida
   Dolores Zomeno, Maria
   Vioque, Jesus
   Alfredo Martinez, Jose
   Romaguera, Dora
   Perez-Farinos, Napoleon
   Lopez-Miranda, Jose
   Estruch, Ramon
   Bueno-Cavanillas, Aurora
   Aros, Fernando
   Antoni Tur, Josep
   Tinahones, Francisco
   Serra-Majem, Lluis
   Marcos-Delgado, Alba
   Ortega-Calvo, Manuel
   Vazquez, Clotilde
   Pinto, Xavier
   Vidal, Josep
   Daimiel, Lidia
   Delgado-Rodriguez, Miguel
   Matia, Pilar
   Corella, Dolores
   Diaz-Lopez, Andres
   Babio, Nancy
   Angel Munoz, Miguel
   Fito, Montse
   Gonzalez-Palacios, Sandra
   Abete, Itziar
   Garcia-Rios, Antonio
   Ros, Emilio
   Angel Martinez-Gonzalez, Miguel
CA PREDIMED-PLUS Study Investigators
TI Mediterranean diet and quality of life: Baseline cross-sectional
   analysis of the PREDIMED-PLUS trial
SO PLOS ONE
LA English
DT Article
ID PHYSICAL-ACTIVITY QUESTIONNAIRE; CARDIOVASCULAR-DISEASE; HEALTH-STATUS;
   MORTALITY; ASSOCIATION; VALIDATION; PREVENTION; DEPRESSION; ADHERENCE;
   PATTERN
AB We assessed if a 17-item score capturing adherence to a traditional Mediterranean diet (MedDiet) was associated with better health-related quality of life among older Spanish men and women with overweight or obesity harboring the metabolic syndrome. We analyzed baseline data from 6430 men and women (age 55-70 years) participating in the PREDIMED-Plus study. PREDIMED-Plus is a multi-centre randomized trial testing an energy-restricted MedDiet combined with promotion of physical activity and behavioral therapy for primary cardiovascular prevention compared to a MedDiet alone. Participants answered a 36-item questionnaire about health-related quality of life (HRQoL) and a 17-item questionnaire that assessed adherence to an MedDiet. We used ANCOVA and multivariable-adjusted linear regression models to compare baseline adjusted means of the quality of life scales according to categories of adherence to the MedDiet. Higher adherence to the MedDiet was independently associated with significantly better scores in the eight dimensions of HRQoL. Adjusted differences of > = 3 points between the highest and the lowest dietary adherence groups to the MedDiet were observed for vitality, emotional role, and mental health and of > = 2 points for the other dimensions. In conclusion, this study shows a positive association between adherence to a MedDiet and several dimensions of quality of life.
C1 [Galilea-Zabalza, Inigo; Buil-Cosiales, Pilar; Diez-Espino, Javier] Atenc Primaria Osasunbidea Serv Navarro Salud, Pamplona, Spain.
   [Galilea-Zabalza, Inigo; Buil-Cosiales, Pilar; Salas-Salvado, Jordi; Toledo, Estefania; Ortega-Azorin, Carolina; Diez-Espino, Javier; Vazquez-Ruiz, Zenaida; Alfredo Martinez, Jose; Romaguera, Dora; Lopez-Miranda, Jose; Estruch, Ramon; Aros, Fernando; Antoni Tur, Josep; Tinahones, Francisco; Serra-Majem, Lluis; Ortega-Calvo, Manuel; Vazquez, Clotilde; Pinto, Xavier; Corella, Dolores; Diaz-Lopez, Andres; Angel Munoz, Miguel; Fito, Montse; Ros, Emilio; Angel Martinez-Gonzalez, Miguel] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr CIBERobn, Madrid, Spain.
   [Buil-Cosiales, Pilar; Toledo, Estefania; Diez-Espino, Javier; Vazquez-Ruiz, Zenaida; Angel Martinez-Gonzalez, Miguel] Univ Navarra IdiSNA, Dept Prevent Med & Publ Hlth, Pamplona, Spain.
   [Salas-Salvado, Jordi; Diaz-Lopez, Andres; Babio, Nancy] Univ Rovira & Virgili, Human Nutr Unit, IISPV, Reus, Spain.
   [Ortega-Azorin, Carolina; Corella, Dolores] Univ Valencia, Dept Prevent Med, Valencia, Spain.
   [Dolores Zomeno, Maria] IMIM Hosp del Mar Med Res Inst, Cardiovasc Risk & Nutr, Barcelona, Spain.
   [Dolores Zomeno, Maria; Bueno-Cavanillas, Aurora; Marcos-Delgado, Alba; Delgado-Rodriguez, Miguel] Univ Ramon Llull, Blanquerna Sch Life Sci, Barcelona, Spain.
   [Vioque, Jesus; Gonzalez-Palacios, Sandra] Inst Salud Carlos III, CIBER Epidemiol & Salud Publ, Madrid, Spain.
   [Vioque, Jesus; Gonzalez-Palacios, Sandra] Miguel Hernandez Univ, Nur Epidemiol Unit, ISABIAL FISABIO, Alicante, Spain.
   [Alfredo Martinez, Jose; Abete, Itziar] Univ Navarra, Dept Nutr & Food Sci Physiol & Toxicol, Pamplona, Spain.
   [Romaguera, Dora] Univ Hosp Son Espases, Hlth Res Inst Balearic Isl IdISBa, Palma De Mallorca, Spain.
   [Perez-Farinos, Napoleon] Univ Malaga, Sch Nursing, Malaga, Spain.
   [Lopez-Miranda, Jose; Garcia-Rios, Antonio] Univ Cordoba IMIBIC, Reina Sofia Univ Hosp, Dept Internal Med, Cordoba, Spain.
   [Estruch, Ramon] Univ Barcelona, Hosp Clin, IDIBAPS, Dept Internal Med, Barcelona, Spain.
   [Bueno-Cavanillas, Aurora] Univ Granada, Dept Prevent Med, Granada, Spain.
   [Aros, Fernando] OSI ABABA Univ Hosp Araba, Dept Cardiol, Vitoria, Spain.
   [Aros, Fernando] Univ Basque Country UPV EHU, Vitoria, Spain.
   [Antoni Tur, Josep; Tinahones, Francisco] Univ Malaga, Dept Endocrinol, Univ Hosp, Malaga, Spain.
   [Serra-Majem, Lluis] Univ Las Palmas Gran Canaria, Inst Biomed Res, Las Palmas Gran Canaria, Spain.
   [Marcos-Delgado, Alba] Univ Leon, Inst Biomed IBIOMED, Leon, Spain.
   [Ortega-Calvo, Manuel] Ctr Salud Las Palmeritas, Dept Family Med, Dist Sanitario Atenc Primaria, Seville, Spain.
   [Vazquez, Clotilde] Fdn Jimenez Diaz, Dept Endocrinol, Madrid, Spain.
   [Pinto, Xavier] Hosp Univ Bellvitge, Lipids & Vasc Risk Unit, Internal Med, Barcelona, Spain.
   [Vidal, Josep] Inst Salud Carlos III, CIBER Diabet & Enfermedades Metab, Madrid, Spain.
   [Vidal, Josep] Univ Barcelona, Dept Endocrinol, IDIBAPS, Hosp Clin, Barcelona, Spain.
   [Daimiel, Lidia] CEI UAM CSIC, Nutr Genom & Epigen Grp, IMDEA Food, Madrid, Spain.
   [Delgado-Rodriguez, Miguel] Univ Jaen, Div Prevent Med, Jaen, Spain.
   [Matia, Pilar] Hosp Clin San Carlos, Inst Invest Sanitaria, Madrid, Spain.
   [Angel Munoz, Miguel; Fito, Montse] Inst Municipal Invest Med, Lipids & Cardiovasc Epidemiol Res Unit, Barcelona, Spain.
   [Ros, Emilio] Hosp Clin Barcelona, Lipid Clin, Inst Invest Biomed August Pi Sunyer IDIBAPS, Barcelona, Spain.
   [Angel Martinez-Gonzalez, Miguel] Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA.
C3 CIBER - Centro de Investigacion Biomedica en Red; CIBEROBN; Instituto de
   Salud Carlos III; University of Navarra; Universitat Rovira i Virgili;
   Institut d'Investigacio Sanitaria Pere Virgili (IISPV); University of
   Valencia; Hospital del Mar Research Institute; Hospital del Mar;
   Universitat Ramon Llull; Instituto de Salud Carlos III; CIBER - Centro
   de Investigacion Biomedica en Red; CIBERESP; General University Hospital
   of Alicante; Universidad Miguel Hernandez de Elche; Universitat
   d'Alacant; Instituto de Investigacion Sanitaria y Biomedica de Alicante
   (ISABIAL); University of Navarra; Institut Investigacio Sanitaria Illes
   Balears (IdISBa); Hospital Universitari Son Espases; Universidad de
   Malaga; University of Barcelona; Hospital Clinic de Barcelona; IDIBAPS;
   University of Granada; University of Basque Country; Universidad de
   Malaga; Universidad de Las Palmas de Gran Canaria; Universidad de Leon;
   Institut d'Investigacio Biomedica de Bellvitge (IDIBELL); Bellvitge
   University Hospital; University of Barcelona; CIBER - Centro de
   Investigacion Biomedica en Red; CIBERDEM; Instituto de Salud Carlos III;
   University of Barcelona; Hospital Clinic de Barcelona; IDIBAPS; Consejo
   Superior de Investigaciones Cientificas (CSIC); IMDEA Food Institute;
   Universidad de Jaen; Hospital Clinico San Carlos; University of
   Barcelona; Hospital Clinic de Barcelona; IDIBAPS; Harvard University;
   Harvard T.H. Chan School of Public Health
RP Martínez-González, MA (corresponding author), Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr CIBERobn, Madrid, Spain.; Martínez-González, MA (corresponding author), Univ Navarra IdiSNA, Dept Prevent Med & Publ Hlth, Pamplona, Spain.; Martínez-González, MA (corresponding author), Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA.
RI Estruch, Ramon/AAZ-3723-2020; Vidal, Josep/MIK-6936-2025; Marcos,
   Alba/AAN-4297-2020; Corella, Dolores/L-9888-2014; Vioque,
   Jesus/A-1066-2008; Serra-Majem, Lluis/I-6708-2019; Romaguera,
   Dora/AAB-2852-2020; Tejada, Silvia/L-7297-2014; Toledo,
   Estefania/H-6211-2014; Rodríguez, Miguel/KCZ-1828-2024; Tinahones,
   Francisco/AAB-2882-2020; Babio, Nancy/AAN-2715-2020; Tur,
   Josep/AAE-5748-2020; Palacios, Sandra/AAA-9585-2021; Lopez-Miranda,
   Jose/Y-8306-2019; Ortega-Azorín, Carolina/AAB-2355-2019; Pintó,
   Xavier/AGI-4297-2022; Martinez-Gonzalez, Miguel/AAE-7669-2019; Pons,
   Antoni/L-4844-2014; Salas-Salvado, Jordi/C-7229-2017; MACIAS-GONZALEZ,
   MANUEL/E-7584-2016; Daimiel-Ruiz, Lidia Angeles/M-7779-2014;
   Gutierrez-Bedmar, Mario/F-2364-2018; Moreno Morales, Noelia/E-1141-2018;
   Canudas, Silvia/K-4184-2014; Fernandez Garcia, Jose Carlos/B-3723-2013;
   Vazquez-Ruiz, Zenaida/AAB-7202-2020; BES-RASTROLLO, MAIRA/A-1329-2009;
   Salas-Huetos, Albert/A-8509-2011; Camacho-Barcia, Lucia/AAB-2096-2021;
   Prieto, Rafel M./J-3995-2017; Ortega-Calvo, Manuel/D-6960-2015;
   Tosca-Segura, Ricardo/N-8680-2019; Ruiz-Canela, Miguel/I-7738-2016; Fito
   Colomer, Montse/C-1822-2012; Bueno Cavanillas, Aurora/O-1513-2015;
   FERNANDEZ-ARANDA, FERNANDO/L-9762-2014; Forcano Gamazo,
   Laura/B-1154-2017; Martin, Vicente/A-1597-2008; Botella,
   Cristina/F-9230-2010; Warnberg, Julia/G-1390-2011; Delgado Rodriguez,
   Miguel/H-4940-2017; Camafort-Babkowski, Miguel/H-6310-2014
OI Salaverria Lete, Itziar/0000-0002-9504-4668; TELLO,
   SUSANNA/0000-0002-0423-8281; Pons, Antoni/0000-0003-2447-3868; Capo
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   Jordi/0000-0003-2700-7459; Colom Fernandez, Antoni/0000-0001-5041-0778;
   Tojal Sierra, Lucas/0000-0001-5338-9601; MACIAS-GONZALEZ,
   MANUEL/0000-0002-6475-4704; Pinto Sala, Xavier/0000-0002-2216-2444;
   Hernandez Rivas, Pablo Ignacio/0000-0002-6691-7618; Daimiel-Ruiz, Lidia
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   Canudas, Silvia/0000-0002-5630-1588; Fernandez Garcia, Jose
   Carlos/0000-0003-2308-2865; iturralde iriso, jesus/0000-0002-7800-3928;
   San Onofre Bernat, Nadia/0000-0003-1029-0681; Bouzas Velasco,
   Cristina/0000-0002-1407-8461; Vazquez-Ruiz, Zenaida/0000-0002-6828-9627;
   BES-RASTROLLO, MAIRA/0000-0002-9139-4206; Castaner Nino,
   Olga/0000-0003-3169-997X; MARTINEZ PEREZ, MARIA
   MAGDALENA/0009-0003-9227-8404; Buil-Cosiales, Pilar/0000-0002-8586-577X;
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   Emili/0000-0001-8818-1907; JULIBERT, ALICIA/0000-0002-6040-0482; Cuenca
   Royo, Aida/0000-0001-8551-5457; Compan Gabucio, Laura
   M/0000-0001-5324-1535; Marcos-Delgado, Alba/0000-0002-7852-1282; Tercero
   Macia, Cristina/0009-0000-6092-9231; Salas-Huetos,
   Albert/0000-0001-5914-6862; , Antoni/0000-0001-8656-6838; Sierra,
   Cristina/0000-0002-6870-4886; Boronat, Anna/0000-0003-0852-3634; Zomeno,
   M. Dolores/0000-0003-1280-7680; Abbate, Manuela/0000-0001-9905-2414;
   Vioque, Jesus/0000-0002-2284-148X; Vila-Domenech, Joan
   Salvador/0000-0002-0413-9291; Mestres, Gaspar/0000-0002-8699-7037;
   Camacho-Barcia, Lucia/0000-0002-5989-936X; Sabate,
   Joan/0000-0002-9063-9785; Fernandez-Crehuet Navajas,
   Joaquin/0000-0002-1173-9906; Prieto, Rafel M./0000-0001-8814-900X;
   Ortega-Calvo, Manuel/0000-0003-2391-0106; Fernandez Soto, Gerardo
   Fernando/0000-0002-0246-0380; Tosca-Segura, Ricardo/0000-0003-2271-8171;
   Garcia de la Hera, Manuela/0000-0001-5742-2704; Ruiz-Canela,
   Miguel/0000-0002-7684-2787; Fito Colomer, Montse/0000-0002-1817-483X;
   Diaz-Lopez, Andres/0000-0002-7500-5629; Cano-Ibanez,
   Naomi/0000-0002-3640-5486; Ortega Martinez de Victoria,
   Emilio/0000-0002-2217-8905; Bueno Cavanillas,
   Aurora/0000-0002-0649-3016; Pena Orihuela, Patricia
   J/0009-0009-9970-043X; Abellan Cano, Ivan/0000-0002-9587-5445; Munoz,
   Miguel-Angel/0000-0002-4083-3248; Torres Pena, Jose
   D./0000-0003-1366-5549; Lopez-Miranda, Jose/0000-0002-8844-0718; ELOSUA,
   ROBERTO/0000-0001-8235-0095; FERNANDEZ-ARANDA,
   FERNANDO/0000-0002-2968-9898; Orozco-Beltran,
   Domingo/0000-0002-8231-2635; Mariscal, Alberto/0000-0002-4684-2161;
   Estan Capell, Nuria/0000-0001-8768-3139; Romeo-Ollora,
   Jorge/0000-0003-0378-8908; Forcano Gamazo, Laura/0000-0002-8478-1451;
   Martin, Vicente/0000-0003-0552-2804; Domenech,
   Monica/0000-0001-5447-6686; Botella, Cristina/0000-0001-8783-6959;
   Warnberg, Julia/0000-0002-8408-316X; Delgado Rodriguez,
   Miguel/0000-0002-3838-2548; Sanchez Villegas,
   Almudena/0000-0001-7733-9238; Vidal Cortada, Josep/0000-0002-4564-4518;
   Gonzalez Palacios, Sandra/0000-0003-3358-472X; Bautista-Castano,
   Inmaculada/0000-0001-9257-8739; Romaguera, Dora/0000-0002-5762-8558;
   Garcia-Gavilan, Jesus Francisco/0000-0002-3707-5255; Hernaez,
   Alvaro/0000-0001-8593-1477; Riquelme Gallego,
   Blanca/0000-0003-3422-7310; Cabre Vila, Juan Jose/0000-0003-1082-6861;
   Camafort-Babkowski, Miguel/0000-0002-8669-6410; Tinahones, Francisco
   J/0000-0001-6871-4403; de la Torre, Rafael/0000-0002-6765-1866
FU European Research Council [340918]; Spanish Ministry of Health -
   Institute de Salud Carlos III (ISCIII) through the Fondo de
   Investigacion para la Salud (FIS); European Regional Development Fund
   [P113/00673, P113/00492, P113/00272, PI13/01123, P113/00462, P113/00233,
   P113/02184, P113/00728, P113/01090, P113/01056, P114/01722, P114/00636,
   P114/00618, PI14/00696, P114/01206, P114/01374, P114/01919, P114/00853,
   P116/00743, P116/00501, P117/000508]; Recercaixa grant [2013ACUP00194];
   Consejeria de Salud de la Junta de Andalucia [P10458/2013]; SEMERGEN
   grant
FX This project is funded by the European Research Council (Advanced
   Research Grant 2013-2018; 340918) granted to MAM-G, the Spanish Ministry
   of Health - Institute de Salud Carlos III (ISCIII) for the periods
   2014-2016, 2015-2017, 2017-2019 and 2018-2020, through the Fondo de
   Investigacion para la Salud (FIS), which is co-funded by the European
   Regional Development Fund (four coordinated FIS grants lead by Jordi
   Salas-Salvado and Josep Vidal, including the following projects:
   P113/00673, P113/00492, P113/00272, PI13/01123, P113/00462, P113/00233,
   P113/02184, P113/00728 P113/01090 P113/01056, P114/01722, P114/00636,
   P114/00618, PI14/00696, P114/01206, P114/01374, P114/01919, P114/00853,
   P116/00743 P116/00501, P117/000508), by a Recercaixa grant 2013
   (2013ACUP00194), by a grant from the Consejeria de Salud de la Junta de
   Andalucia (P10458/2013), and a SEMERGEN grant. None of these funding
   sources plays any role in the design, collection, analysis, or
   interpretation of the data or in the decision to submit manuscripts for
   publication.
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NR 36
TC 96
Z9 97
U1 2
U2 29
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JUN 18
PY 2018
VL 13
IS 6
AR e0198974
DI 10.1371/journal.pone.0198974
PG 18
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA GJ6XV
UT WOS:000435528600065
PM 29912978
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Surapongchai, J
   Rattanavichit, Y
   Buniam, J
   Saengsirisuwan, V
AF Surapongchai, Juthamard
   Rattanavichit, Yupaporn
   Buniam, Jariya
   Saengsirisuwan, Vitoon
TI Exercise Protects Against Defective Insulin Signaling and Insulin
   Resistance of Glucose Transport in Skeletal Muscle of Angiotensin
   II-Infused Rat
SO FRONTIERS IN PHYSIOLOGY
LA English
DT Article
DE angiotensin II; insulin signaling; insulin resistance; MAPK; soleus
   muscle; voluntary exercise
ID OBESE ZUCKER RATS; METABOLIC SYNDROME; DEPENDENT MECHANISM;
   CARDIOVASCULAR RISK; GENETIC SELECTION; NADPH OXIDASE; SYSTEM;
   HYPERTENSION; ACTIVATION; MICE
AB Objectives : The present study investigated the impact of voluntary exercise on insulin-stimulated glucose transport and the protein expression and phosphorylation status of the signaling molecules known to be involved in the glucose transport process in the soleus muscle as well as other cardiometabolic risks in a rat model with insulin resistance syndrome induced by chronic angiotensin II (ANGII) infusion.
   Materials and Methods : Male Sprague-Dawley rats were assigned to sedentary or voluntary wheel running (VWR) groups. Following a 6-week period, rats in each group were subdivided and subcutaneously administered either normal saline or ANGII at 100 ng/kg/min for 14 days. Blood pressure, glucose tolerance, insulin-stimulated glucose transport and signaling proteins, including insulin receptor (IR), insulin receptor substrate 1 (IRS-1), Akt, Akt substrate of 160 kDa (AS160), AMPK alpha, c-Jun NH2-terminal kinase (JNK), p38 MAPK, angiotensin converting enzyme (ACE), ANGII type 1 receptor (AT1R), ACE2, Mas receptor (MasR) and oxidative stress marker in the soleus muscle, were evaluated.
   Results : Exercise protected against the insulin resistance of glucose transport and defective insulin signaling molecules in the soleus muscle; this effect was associated with a significant increase in AMPK Thr(172) (43%) and decreases in oxidative stress marker (31%) and insulin-induced p38 MAPK Thr(180)/Tyr(182) (45%) and SAPK/JNK Thr(183)/Tyr(185) (25%), without significant changes in expression of AT1R, AT2R, ACE, ACE2, and MasR when compared to the sedentary rats given ANGII infusion. At the systemic level, VWR significantly decreased body weight, fat weight, and systolic blood pressure as well as improved serum lipid profiles.
   Conclusion : Voluntary exercise can alleviate insulin resistance of glucose transport and impaired insulin signaling molecules in the soleus muscle and improve whole-body insulin sensitivity in rats chronically administered with ANGII.
C1 [Surapongchai, Juthamard; Rattanavichit, Yupaporn; Buniam, Jariya; Saengsirisuwan, Vitoon] Mahidol Univ, Fac Sci, Dept Physiol, Exercise Physiol Lab, Bangkok, Thailand.
C3 Mahidol University
RP Saengsirisuwan, V (corresponding author), Mahidol Univ, Fac Sci, Dept Physiol, Exercise Physiol Lab, Bangkok, Thailand.
EM vitoon.sae@mahidol.ac.th
RI Buniam, Jariya/ADN-3845-2022; Saengsirisuwan, Vitoon/AAF-7567-2020;
   Surapongchai, Juthamard/JEF-7715-2023
OI Buniam, Jariya/0000-0001-5066-9552
FU Faculty of Science, Mahidol University; Thailand Research Fund through
   the Royal Golden Jubilee Ph.D. Program [PHD/0228/2552]
FX This work was supported by grants from the Faculty of Science, Mahidol
   University, and from the Thailand Research Fund through the Royal Golden
   Jubilee Ph.D. Program (Grant PHD/0228/2552). The authors wish to thank
   Natsasi Chukijrungroat for technical assistance.
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Z9 8
U1 0
U2 8
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-042X
J9 FRONT PHYSIOL
JI Front. Physiol.
PD APR 11
PY 2018
VL 9
AR 358
DI 10.3389/fphys.2018.00358
PG 13
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA GC3QS
UT WOS:000429699200001
PM 29695972
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Xu, ZX
   Lei, X
   Chu, WW
   Weng, LQ
   Chen, CS
   Ye, R
AF Xu, Zhixiao
   Lei, Xiong
   Chu, Weiwei
   Weng, Luoqi
   Chen, Chengshui
   Ye, Ran
TI Oxidative balance score was negatively associated with the risk of
   metabolic syndrome, metabolic syndrome severity, and all-cause mortality
   of patients with metabolic syndrome
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Article
DE oxidative stress; metabolic syndrome; lifestyles; diet; mortality
ID REDOX BIOLOGY; FREE-RADICALS; STRESS; ANTIOXIDANTS; PATHOGENESIS;
   VITAMIN-B2; DISEASE; NIACIN; SEX
AB Background The oxidative balance score (OBS), an encompassing scoring mechanism for assessing oxidative stress, is formulated based on nutritional and lifestyle components. The emergence of metabolic syndrome (MetS) is intricately linked to oxidative stress. Nonetheless, the correlation between OBS and MetS displays variability within distinct cohorts. Objective We worked on the relationships between OBS and the risk of MetS, MetS severity, and all-cause mortality of MetS patients. Methods A total of 11,171 adult participants were collected from the U.S. National Health Examination Survey (NHANES) 2007-2018. Employing survey-weighted logistic models, we evaluated the relationship between OBS and MetS risk. Furthermore, survey-weighted linear models were utilized to investigate the connection between OBS and MetS severity. Among the participants, 3,621 individuals had their survival status recorded, allowing us to employ Cox proportional hazards regression models in order to ascertain the association between OBS and the all-cause mortality within the subset of individuals with MetS. The OBS (where a higher OBS signified an increased prevalence of anti- or pro-oxidant exposures) weighed the 20 factors, while the MetS severity score weighed the five factors. Results After multivariable adjustment, individuals with elevated OBS were found to exhibit a decreased susceptibility to MetS [odds ratio (OR) 0.95; 95% CI 0.94-0.96]. The adjusted OR was 0.42 (95% CI 0.33-0.53) for MetS risk in the fourth OBS quartile compared with those in the first OBS quartile (P for trend < 0.001). A one-unit increase in OBS was linked to a 3% reduction in MetS severity score by 3% (mean difference, -0.03; 95% CI, -0.04 to -0.03). Moreover, increased OBS correlated with decreased hazard of all-cause mortality risk among MetS subjects (adjusted hazard ratio, 0.95; 95% CI, 0.93-0.98). These associations retained their strength even subsequent to the introduction of sensitivity analyses. There existed a statistically significant negative correlation between diet/lifestyle OBS and both MetS risk as well as MetS severity. Conclusions An inverse correlation was observed between OBS and the susceptibility to MetS, MetS severity, and all-cause mortality of MetS patients. Health outcomes for MetS patients were positively related to antioxidant diets and lifestyles.
C1 [Xu, Zhixiao; Lei, Xiong; Weng, Luoqi; Chen, Chengshui] Wenzhou Med Univ, Dept Pulm & Crit Care Med, Affiliated Hosp 1, Wenzhou, Peoples R China.
   [Chu, Weiwei] Anhui Med Univ, Luan Peoples Hosp Anhui Prov, Dept Pulm & Crit Care Med, Luan Hosp, Luan, Peoples R China.
   [Chen, Chengshui] Wenzhou Med Univ, Key Lab Intervent Pulmonol Zhejiang Prov, Affiliated Hosp 1, Wenzhou, Peoples R China.
   [Chen, Chengshui] Wenzhou Med Univ, Quzhou Peoples Hosp, Quzhou Affiliated Hosp, Quzhou, Peoples R China.
   [Ye, Ran] Wenzhou Med Univ, Affiliated Hosp 2, Dept Ultrasonog, Wenzhou, Peoples R China.
   [Ye, Ran] Wenzhou Med Univ, Yuying Childrens Hosp, Wenzhou, Peoples R China.
C3 Wenzhou Medical University; Anhui Medical University; Wenzhou Medical
   University; Wenzhou Medical University; Wenzhou Medical University;
   Wenzhou Medical University
RP Chen, CS (corresponding author), Wenzhou Med Univ, Dept Pulm & Crit Care Med, Affiliated Hosp 1, Wenzhou, Peoples R China.; Chen, CS (corresponding author), Wenzhou Med Univ, Key Lab Intervent Pulmonol Zhejiang Prov, Affiliated Hosp 1, Wenzhou, Peoples R China.; Chen, CS (corresponding author), Wenzhou Med Univ, Quzhou Peoples Hosp, Quzhou Affiliated Hosp, Quzhou, Peoples R China.; Ye, R (corresponding author), Wenzhou Med Univ, Affiliated Hosp 2, Dept Ultrasonog, Wenzhou, Peoples R China.; Ye, R (corresponding author), Wenzhou Med Univ, Yuying Childrens Hosp, Wenzhou, Peoples R China.
EM chenchengshui@wmu.edu.cn; ranyewenz@163.com
RI 褚, 维伟/IZQ-3812-2023
FU Key Laboratory of Interventional Pulmonology of Zhejiang Province
   [2019E10014]; Zhejiang Provincial Key Research and Development Program
   [2020C03067]; National Nature Science Foundation of China [82170017]
FX The author(s) declare financial support was received for the research,
   authorship, and/or publication of this article. This work was
   financially supported by the Key Laboratory of Interventional
   Pulmonology of Zhejiang Province (2019E10014), the Zhejiang Provincial
   Key Research and Development Program (2020C03067), and the National
   Nature Science Foundation of China (82170017).
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NR 59
TC 23
Z9 23
U1 7
U2 12
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD JAN 12
PY 2024
VL 14
AR 1233145
DI 10.3389/fendo.2023.1233145
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA GD2C0
UT WOS:001150651500001
PM 38283746
OA gold, Green Published
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Mastinu, A
   Pira, M
   Pinna, GA
   Pisu, C
   Casu, MA
   Reali, R
   Marcello, S
   Murineddu, G
   Lazzari, P
AF Mastinu, Andrea
   Pira, Marilena
   Pinna, Gerard Aime
   Pisu, Carla
   Casu, Maria Antonietta
   Reali, Roberta
   Marcello, Stefania
   Murineddu, Gabriele
   Lazzari, Paolo
TI NESS06SM reduces body weight with an improved profile relative to
   SR141716
SO PHARMACOLOGICAL RESEARCH
LA English
DT Article
DE NESS06SM; SR141716A; Obesity; DIO mice; Mood disorders
ID CARDIOMETABOLIC RISK-FACTORS; CANNABINOID CB1 RECEPTOR; MESOLIMBIC
   DOPAMINE SYSTEM; ENDOCANNABINOID SYSTEM; FOOD-INTAKE; BIOLOGICAL
   EVALUATION; TRICYCLIC PYRAZOLES; THERAPEUTIC TARGETS; LIPID-METABOLISM;
   RIMONABANT
AB We have recently synthesized a new series of 4,5-dihydrobenzo-oxa-cycloheptapyrazole derivatives with the aim to discover novel CBI antagonist agents characterized by anti-obesity activity comparable to that of SR141716A but with reduced adverse effects such as anxiety and depression. Within the novel class, the CB1 antagonist 8-chloro-1-(2,4-dichlorophenyl)-N-piperidin-1-yl-4,5-dihydrobenzo-1H-6-oxa-cyclohepta(1,2-c)pyrazole-3-carboxamide (NESS06SM) has been selected as lead compound. We found that NESS06SM is a CBI neutral antagonist, characterized by poor blood brain barrier permeability. Moreover, NESS06SM chronic treatment determined both anti-obesity effect and cardiovascular risk factor improvement in C57BL/6N Diet Induced Obesity (DIO) mice fed with fat diet (FD mice). In fact, the mRNA gene expression in Central Nervous System (CNS) and peripheral tissues by real time PCR, showed a significant increase of orexigenic peptides and a decrease of anorexigenic peptides elicited by NESS06SM treatment, compared to control mice fed with the same diet. Moreover, in contrast to SR141716A treatment, the chronic administration of NESS06SM did not change mRNA expression of both monoaminergic transporters and neurotrophins highly related with anxiety and mood disorders. Our results suggest that NESS06SM reduces body weight and it can restore the disrupted expression profile of genes linked to the hunger-satiety circuit without altering monoaminergic transmission probably avoiding SR141716A side effects. Therefore the novel CBI neutral antagonist could represent a useful candidate agent for the treatment of obesity and its metabolic complications. (C) 2013 Elsevier Ltd. All rights reserved.
C1 [Mastinu, Andrea; Casu, Maria Antonietta; Marcello, Stefania] UOS Cagliari, CNR, Ist Farmacol Traslaz, I-09010 Pula, CA, Italy.
   [Mastinu, Andrea] Univ Cagliari, Dipartimento Sci Biomed, I-09042 Monserrato, CA, Italy.
   [Pira, Marilena; Pisu, Carla; Reali, Roberta; Lazzari, Paolo] Neurosci PharmaNess Scarl, I-09010 Pula, CA, Italy.
   [Pira, Marilena; Pinna, Gerard Aime; Murineddu, Gabriele; Lazzari, Paolo] Univ Sassari, Dipartimento Chim & Farm, I-07100 Sassari, SS, Italy.
C3 Consiglio Nazionale delle Ricerche (CNR); Istituto di Farmacologia
   Traslazionale (IFT-CNR); University of Cagliari; University of Sassari
RP Mastinu, A (corresponding author), UOS Cagliari, CNR, Ist Farmacol Traslaz, Edificio 5, I-09010 Pula, CA, Italy.
EM andrea.mastinu@ift.cnr.it; paolo.lazzari@pharmaness.com
RI ; MASTINU, ANDREA/G-4401-2017
OI MURINEDDU, Gabriele/0000-0002-2791-9178; MASTINU,
   ANDREA/0000-0002-8862-2896; CASU, MARIA ANTONIETTA/0000-0001-8105-6652
FU MIUR [DM 28141]
FX This study was supported in part by grants from MIUR (project:
   "Cannabinoidi e Obesita: antagonisti del recettore cannabinoidergico CB1
   e loro implicazioni nel trattamento dell'obesita e sul consumo di cibo",
   DM 28141).
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NR 97
TC 28
Z9 29
U1 0
U2 4
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 1043-6618
J9 PHARMACOL RES
JI Pharmacol. Res.
PD AUG
PY 2013
VL 74
BP 94
EP 108
DI 10.1016/j.phrs.2013.06.001
PG 15
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 204VT
UT WOS:000323400100011
PM 23756200
DA 2025-06-11
ER

PT J
AU Dinel, AL
   André, C
   Aubert, A
   Ferreira, G
   Layé, S
   Castanon, N
AF Dinel, Anne-Laure
   Andre, Caroline
   Aubert, Agnes
   Ferreira, Guillaume
   Laye, Sophie
   Castanon, Nathalie
TI Lipopolysaccharide-induced brain activation of the indoleamine
   2,3-dioxygenase and depressive-like behavior are impaired in a mouse
   model of metabolic syndrome
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE Lipopolysaccharide; Cytokines; Indoleamine 2,3-dioxygenase; Forced swim
   test; db/db mice; Metabolic syndrome; Depression; Hippocampus
ID CHRONIC IMMUNE ACTIVATION; BACILLE CALMETTE-GUERIN; PROINFLAMMATORY
   CYTOKINES; TRYPTOPHAN-METABOLISM; KYNURENINE PATHWAY; AGED MICE;
   EXPRESSION; LPS; INFLAMMATION; INDUCTION
AB Although peripheral low-grade inflammation has been associated with a high incidence of mood symptoms in patients with metabolic syndrome (MetS), much less is known about the potential involvement of brain activation of cytokines in that context. Recently we showed in a mouse model of MetS, namely the db/db mice, an enhanced hippocampal inflammation associated with increased anxiety-like behavior (Dinel et al., 2011). However, depressive-like behavior was not affected in db/db mice. Based on the strong association between depressive-like behavior and cytokine-induced brain activation of indoleamine 2,3-dioxygenase (IDO), the enzyme that metabolizes tryptophan along the kynurenine pathway, these results may suggest an impairment of brain IDO activation in db/db mice. To test this hypothesis, we measured the ability of db/db mice and their healthy db/+ littermates to enhance brain IDO activity and depressive-like behavior after a systemic immune challenge with lipopolysaccharide (LPS).
   Here we show that LPS (5 mu g/mouse) significantly increased depressive-like behavior (increased immobility time in a forced-swim test, FST) 24 h after treatment in db/+ mice, but not in db/db mice. Interestingly, db/db mice also displayed after LPS treatment blunted increase of brain kynurenine/tryptophan ratio compared to their db/+ counterparts, despite enhanced induction of hippocampal cytokine expression (interleukin-1 beta, tumor necrosis factor-a). Moreover, this was associated with an impaired effect of LPS on hippocampal expression of the brain-derived neurotrophic factor (BDNF) that contributes to mood regulation, including under inflammatory conditions.
   Collectively, these data indicate that the rise in brain tryptophan catabolism and depressive-like behavior induced by innate immune system activation is impaired in db/db mice. These findings could have relevance in improving the management and treatment of inflammation-related complications in MetS. (C) 2013 Elsevier Ltd. All rights reserved.
C1 [Dinel, Anne-Laure; Aubert, Agnes; Ferreira, Guillaume; Laye, Sophie; Castanon, Nathalie] INRA, UMR 1286, F-33076 Bordeaux, France.
   [Dinel, Anne-Laure; Andre, Caroline; Aubert, Agnes; Ferreira, Guillaume; Laye, Sophie; Castanon, Nathalie] Univ Bordeaux, UMR 1286, F-33076 Bordeaux, France.
   [Andre, Caroline] INSERM, U862, F-33076 Bordeaux, France.
C3 INRAE; Universite de Bordeaux; Institut National de la Sante et de la
   Recherche Medicale (Inserm); Universite de Bordeaux; Institut National
   de la Sante et de la Recherche Medicale (Inserm); Universite de
   Bordeaux; Institut National de la Sante et de la Recherche Medicale
   (Inserm)
RP Castanon, N (corresponding author), Univ Victor Segalen, INRA UMR 1286, Batiment UFR Pharm,2 Tranche,2 Etage, F-33076 Bordeaux, France.
EM nathalie.castanon@bordeaux.inra.fr
RI Laye, Sophie/AAX-2501-2020
OI Ferreira, Guillaume/0000-0001-5984-8143; Laye,
   Sophie/0000-0002-3843-1012; Castanon, Nathalie/0000-0002-0079-0562
FU Institut National de la Recherche Agronomique; Region Aquitaine;
   Institut Danone
FX This work was supported by the Institut National de la Recherche
   Agronomique and by the Region Aquitaine. ALD was supported by a doctoral
   fellowship from the Institut Danone. The funders had no role in study
   design, data collection and analysis, decision to publish, or
   preparation of the manuscript.
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NR 64
TC 64
Z9 71
U1 0
U2 19
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD FEB
PY 2014
VL 40
BP 48
EP 59
DI 10.1016/j.psyneuen.2013.10.014
PG 12
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA AB6TB
UT WOS:000331921300006
PM 24485475
DA 2025-06-11
ER

PT J
AU Robinson, JD
   Cinciripini, PM
   Karam-Hage, M
   Aubin, HJ
   Dale, LC
   Niaura, R
   Anthenelli, RM
AF Robinson, Jason D.
   Cinciripini, Paul M.
   Karam-Hage, Maher
   Aubin, Henri-Jean
   Dale, Lowell C.
   Niaura, Raymond
   Anthenelli, Robert M.
CA STRATUS Grp
TI Pooled analysis of three randomized, double-blind, placebo controlled
   trials with rimonabant for smoking cessation
SO ADDICTION BIOLOGY
LA English
DT Article
DE Cannabinoid receptors; pharmacotherapy; rimonabant; smoking cessation;
   weight gain
ID CANNABINOID CB1 RECEPTOR; CARDIOMETABOLIC RISK-FACTORS; NICOTINE-SEEKING
   BEHAVIOR; LONG-TERM DEPRESSION; ATTENUATES REINSTATEMENT; OVERWEIGHT
   PATIENTS; NUCLEUS-ACCUMBENS; HOSPITAL ANXIETY; CUE REACTIVITY;
   CANNABIDIOL
AB Despite the withdrawal of CB1 antagonists, such as rimonabant, from the market and from active clinical development because of concerns about their side effect profiles, research suggests that the endocannabinoid system may play an important role in modulating nicotine's effects. We report the combined results, using a pooled analysis, of three previously unpublished trials assessing rimonabant as a smoking cessation pharmacotherapy conducted between 2002 and 2004. Smokers (n = 2097) motivated to quit were enrolled in three randomized, double-blind, placebo-controlled trials, STRATUS EU, US, and META, which consisted of a 10-week treatment period with either rimonabant 20 mg (n = 789), 5 mg (n = 518; used in only two of the three studies), or placebo (n = 790), in conjunction with brief counseling. The impact of drug on prolonged abstinence and adverse events was examined at 8 weeks (end-of-treatment) and at 48 weeks (available for STRATUS EU and US) after the targeted quit date. Rimonabant 20 mg resulted in significantly higher abstinence at end-of-treatment and at 48 weeks post-targeted quit date compared with placebo, while rimonabant 5 mg and placebo did not differ. Serious AEs did not differ by drug group. The 20 mg rimonabant dose, compared with placebo, produced increased nausea, diarrhea, anxiety symptoms, hyporexia, and vomiting, and decreased headache, constipation, and cough. These results support rimonabant 20 mg as a modestly effective aid for smoking cessation. Although work on CB1 antagonists such as rimonabant has mostly been stopped because of unacceptable adverse events, these results may inform and spur the development of other endocannabinoids for smoking cessation.
C1 [Robinson, Jason D.; Cinciripini, Paul M.; Karam-Hage, Maher] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA.
   [Aubin, Henri-Jean] Univ Paris Sud, Univ Paris Saclay, Hop Univ Paris Sud, AP HP,CESP,UVSQ,INSERM, Villejuif, France.
   [Dale, Lowell C.] Mayo Clin, Rochester, MN USA.
   [Niaura, Raymond] Schroeder Inst Tobacco Res & Policy Studies, Washington, DC USA.
   [Anthenelli, Robert M.] Univ Calif San Diego, San Diego, CA 92103 USA.
C3 University of Texas System; UTMD Anderson Cancer Center; Universite
   Paris Saclay; Assistance Publique Hopitaux Paris (APHP); Hopital
   Universitaire Paul-Brousse - APHP; Institut National de la Sante et de
   la Recherche Medicale (Inserm); Mayo Clinic; University of California
   System; University of California San Diego
RP Robinson, JD (corresponding author), MD Anderson Canc Ctr, Dept Behav Sci, Unit 1330,POB 301439, Houston, TX 77230 USA.
EM jdrobinson@mdanderson.org
RI Karam-Hage, Maher/AAE-5053-2019; Aubin, Henri-Jean/AAP-8605-2021;
   Niaura, Raymond/AAE-7319-2019; Cinciripini, Paul/I-5773-2012; Robinson,
   Jason/C-6433-2009
OI Niaura, Raymond/0000-0002-0856-3540; Robinson, Jason
   D./0000-0002-1588-9637; Aubin, Henri-Jean/0000-0002-6604-6672
FU Sanofi-Aventis; MD Anderson's Cancer Center Support Grant - National
   Cancer Institute [CA016672]
FX This study was supported by Sanofi-Aventis, manufacturer of rimonabant.
   Sanofi-Aventis designed the study, funded data collection, and provided
   the dataset, but did not analyze or provide data interpretation for this
   manuscript or provide input regarding its publication. The authors wish
   to thank the principal investigators and study staff of the sites that
   participated in the STRATUS EU, US, META trials, and Owen Hagino,
   Bernard Sebastien, and Marie Sebille of Sanofi-Aventis. Work on this
   manuscript was supported by MD Anderson's Cancer Center Support Grant
   (CA016672), funded by the National Cancer Institute.
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NR 58
TC 24
Z9 24
U1 0
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1355-6215
EI 1369-1600
J9 ADDICT BIOL
JI Addict. Biol.
PD JAN
PY 2018
VL 23
IS 1
BP 291
EP 303
DI 10.1111/adb.12508
PG 13
WC Biochemistry & Molecular Biology; Substance Abuse
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Biochemistry & Molecular Biology; Substance Abuse
GA FW3LU
UT WOS:000425208700026
PM 28429843
OA Green Accepted, Green Submitted
DA 2025-06-11
ER

PT J
AU Patel, D
   Msosa, YJ
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   Arroyo, B
   Larkin, D
   Tiedt, T
   Roberts, A
   Dobson, RJB
   Gaughran, F
   Park, D
AF Patel, Dipen
   Msosa, Yamiko Joseph
   Wang, Tao
   Williams, Julie
   Mustafa, G.
   Gee, Siobhan
   Arroyo, Barbara
   Larkin, Damian
   Tiedt, Trevor
   Roberts, Angus
   Dobson, Richard J. B.
   Gaughran, Fiona
   Park, De Crespigny
TI Implementation of an Electronic Clinical Decision Support System for the
   Early Recognition and Management of Dysglycemia in an Inpatient Mental
   Health Setting Using CogStack: Protocol for a Pilot Hybrid Type 3
   Effectiveness-Implementation Randomized Controlled Cluster Trial
SO JMIR RESEARCH PROTOCOLS
LA English
DT Article
DE blood sugar; CDSS; clinical decision support system; decision support;
   diabetes; diabetic; dysglycemia; electronic clinical decision support;
   hyperglycemia; hypoglycemia; implementation; medical informatics; mental
   health; mental healthcare; mental illness; metabolic health; randomized
   controlled trial; RCT
ID METABOLIC SYNDROME; DIABETES-MELLITUS; BIPOLAR DISORDER; SCHIZOPHRENIA;
   PEOPLE; RISK; COMPLICATIONS; MORTALITY; ADULTS
AB Background: Severe mental illnesses (SMIs), including schizophrenia, bipolar affective disorder, and major depressive disorder, are associated with an increased risk of physical health comorbidities and premature mortality from conditions including cardiovascular disease and diabetes. Digital technologies such as electronic clinical decision support systems (eCDSSs) could play a crucial role in improving the clinician -led management of conditions such as dysglycemia (deranged blood sugar levels) and associated conditions such as diabetes in people with a diagnosis of SMI in mental health settings. Objective: We have developed a real-time eCDSS using CogStack, an information retrieval and extraction platform, to automatically alert clinicians with National Health Service Trust-approved, guideline -based recommendations for dysglycemia monitoring and management in secondary mental health care. This novel system aims to improve the management of dysglycemia and associated conditions, such as diabetes, in SMI. This protocol describes a pilot study to explore the acceptability, feasibility, and evaluation of its implementation in a mental health inpatient setting. Methods: This will be a pilot hybrid type 3 effectiveness -implementation randomized controlled cluster trial in inpatient mental health wards. A ward will be the unit of recruitment, where it will be randomly allocated to receive either access to the eCDSS plus usual care or usual care alone over a 4 -month period. We will measure implementation outcomes, including the feasibility and acceptability of the eCDSS to clinicians, as primary outcomes, alongside secondary outcomes relating to the process of care measures such as dysglycemia screening rates. An evaluation of other implementation outcomes relating to the eCDSS will be conducted, identifying facilitators and barriers based on established implementation science frameworks. Results: Enrollment of wards began in April 2022, after which clinical staff were recruited to take part in surveys and interviews. The intervention period of the trial began in February 2023, and subsequent data collection was completed in August 2023. Data are currently being analyzed, and results are expected to be available in June 2024. Conclusions: An eCDSS can have the potential to improve clinician -led management of dysglycemia in inpatient mental health settings. If found to be feasible and acceptable, then, in combination with the results of the implementation evaluation, the system can be refined and improved to support future successful implementation. A larger and more definitive effectiveness trial should then be conducted to assess its impact on clinical outcomes and to inform scalability and application to other conditions in wider mental health care settings.
C1 [Patel, Dipen; Msosa, Yamiko Joseph; Wang, Tao; Roberts, Angus; Dobson, Richard J. B.; Gaughran, Fiona] Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Psychosis Studies, De Crespigny Pk, London SE5 8AB, England.
   [Patel, Dipen; Gee, Siobhan; Arroyo, Barbara; Larkin, Damian; Tiedt, Trevor; Dobson, Richard J. B.; Gaughran, Fiona] South London & Maudsley Natl Hlth Serv Fdn Trust, Natl Inst Hlth Res, Maudsley Biomed Res Ctr, London, England.
   [Msosa, Yamiko Joseph; Wang, Tao; Roberts, Angus; Dobson, Richard J. B.; Gaughran, Fiona] South London & Maudsley Natl Hlth Serv Fdn Trust, London, England.
   [Williams, Julie; Dobson, Richard J. B.] Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Biostat & Hlth Informat, London, England.
   [Mustafa, G.] Kings Coll London, Ctr Implementat Sci, Hlth Serv & Populat Res Dept, London, England.
   [Mustafa, G.] Kings Coll Hosp London, Natl Hlth Serv Fdn Trust, Dept Diabet, London, England.
   [Dobson, Richard J. B.] Kings Coll London, Fac Life Sci & Med, Ctr Educ, London, England.
   [Dobson, Richard J. B.] UCL, Inst Hlth Informat, London, England.
   [Dobson, Richard J. B.] UCL, Hlth Data Res UK, London, England.
C3 University of London; King's College London; South London & Maudsley NHS
   Trust; South London & Maudsley NHS Trust; University of London; King's
   College London; University of London; King's College London; King's
   College Hospital NHS Foundation Trust; King's College Hospital;
   University of London; King's College London; University of London;
   University College London; University of London; University College
   London
RP Patel, D (corresponding author), Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Psychosis Studies, De Crespigny Pk, London SE5 8AB, England.
EM dipen.1.patel@kcl.ac.uk
RI Gaughran, Fiona/AAC-7160-2019; Williams, Julie/JYQ-5874-2024; Wang,
   Tao/IZQ-3814-2023; Gaughran, Fiona/H-5495-2011; dobson,
   richard/C-9269-2011
OI Patel, Dipen/0000-0003-2341-7901; Gaughran, Fiona/0000-0001-7414-5569;
   dobson, richard/0000-0003-4224-9245; Wang, Tao/0000-0002-0437-0557;
   Roberts, Angus/0000-0002-4570-9801
FU Maudsley Charity; National Institute for Health Research's (NIHR)
   Biomedical Research Centre at South London and Maudsley NHS Foundation
   Trust; King's College London; National Institute for Health Research
   (NIHR) Applied Research Collaboration South London (NIHR ARC South
   London) at King's College Hospital NHS Foundation Trust
FX This work was supported by (1) the Maudsley Charity; (2) the National
   Institute for Health Research's (NIHR) Biomedical Research Centre at
   South London and Maudsley NHS Foundation Trust and King's College
   London; (3) the Maudsley Charity; and (4) the National Institute for
   Health Research (NIHR) Applied Research Collaboration South London (NIHR
   ARC South London) at King's College Hospital NHS Foundation Trust. The
   views expressed are those of the authors and not necessarily those of
   the NIHR or the Department of Health and Social Care.
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NR 31
TC 0
Z9 0
U1 0
U2 0
PU JMIR PUBLICATIONS, INC
PI TORONTO
PA 130 QUEENS QUAY East, Unit 1100, TORONTO, ON M5A 0P6, CANADA
SN 1929-0748
J9 JMIR RES PROTOC
JI JMIR RES. Protoc.
PY 2024
VL 13
AR e49548
DI 10.2196/49548
PG 10
WC Health Care Sciences & Services; Public, Environmental & Occupational
   Health
WE Emerging Sources Citation Index (ESCI)
SC Health Care Sciences & Services; Public, Environmental & Occupational
   Health
GA QT4Q0
UT WOS:001223111600004
PM 38578666
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Johansen, OE
   Birkeland, KI
   Orvik, E
   Flesland, O
   Wergeland, R
   Ueland, T
   Smith, C
   Endresen, K
   Aukrust, P
   Gullestad, L
AF Johansen, O. E.
   Birkeland, K. I.
   Orvik, E.
   Flesland, O.
   Wergeland, R.
   Ueland, T.
   Smith, C.
   Endresen, K.
   Aukrust, P.
   Gullestad, L.
TI Inflammation and coronary angiography in asymptomatic type 2 diabetic
   subjects
SO SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION
LA English
DT Article
DE coronary angiography; coronary artery disease; inflammation; metabolic
   syndrome; prevention; type 2 diabetes mellitus
ID SILENT-MYOCARDIAL-ISCHEMIA; C-REACTIVE PROTEIN; ARTERY-DISEASE;
   METABOLIC SYNDROME; RISK-FACTORS; CARDIOVASCULAR MORTALITY;
   GENERAL-POPULATION; HEART-DISEASE; MELLITUS; PREVALENCE
AB Objective. Coronary artery disease (CAD) is prevalent in patients with type 2 diabetes mellitus (T2DM) and because it is often asymptomatic and extensive in comparison with CAD in subjects without diabetes, it represents a diagnostic challenge. The objective of the study was to investigate the prevalence of CAD in asymptomatic T2DM patients utilizing angiography and to investigate its association with cardiovascular (CV) risk factors, the metabolic syndrome and markers of inflammation. Material and methods. Eighty-two patients with T2DM without symptoms of CAD, and with >= 1 CV risk factor (hypertension, dyslipidaemia, premature familial CAD, smoking or microalbuminuria) underwent a diagnostic stress test and coronary angiography irrespective of stress test results. Stenosis detected in the main coronary arteries >= 50% of lumen diameter was categorized as one-, two- or three-vessel disease. Inflammatory markers were analysed in fasting samples. Results. Fifteen men and two women had significant CAD (21 %) (1-vessel disease, n=10; 2- or 3-vessel disease, n=7). Patients with 2- or 3-vessel disease were significantly older and had a longer duration of diabetes, but the prevalence of other traditional CV risk factors or the metabolic syndrome was similar among those with 1-vessel and those with 2- or 3-vessel disease. Sensitivity for CAD of the stress test was low (0.35). The mean level of the pro-inflammatory marker interleukin-6 was elevated in patients with 2- to 3-vessel CAD as compared to patients with no or 1-vessel CAD (p < 0.05). Conclusions. Significant CAD was found in 21% of asymptomatic patients with T2DM with >= 1 CV risk factor. Inflammatory markers may be helpful in identifying patients that are likely to have significant CAD, but larger studies are warranted.
C1 Asker & Baerum Hosp, Dept Med, NO-1309 Rud, Norway.
   Aker Univ Hosp, Dept Endocrinol, Oslo, Norway.
   Univ Oslo, Aker Univ Hosp, Fac Div, N-0316 Oslo, Norway.
   Asker & Baerum Hosp, Dept Clin Chem, Rud, Norway.
   Univ Hosp Olso, Rikshosp, Dept Clin Chem, Oslo, Norway.
   Univ Hosp Olso, Rikshosp, Internal Med Res Inst, Oslo, Norway.
   Univ Hosp Olso, Rikshosp, Dept Cardiol, Oslo, Norway.
C3 University of Oslo; University of Oslo; University of Oslo; National
   Hospital Norway; University of Oslo; National Hospital Norway;
   University of Oslo; National Hospital Norway
RP Johansen, OE (corresponding author), Asker & Baerum Hosp, Dept Med, POB 83, NO-1309 Rud, Norway.
EM odd.erik.johansen@broadpark.no
RI Birkeland, Kåre/E-9750-2010
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NR 41
TC 17
Z9 17
U1 0
U2 1
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0036-5513
EI 1502-7686
J9 SCAND J CLIN LAB INV
JI Scand. J. Clin. Lab. Invest.
PY 2007
VL 67
IS 3
BP 306
EP 316
DI 10.1080/00365510601045088
PG 11
WC Medical Laboratory Technology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology; Research & Experimental Medicine
GA 166HC
UT WOS:000246368300007
PM 17454845
DA 2025-06-11
ER

PT J
AU Sahin, E
   Saglam, N
   Erdem, S
   Alvuroglu, E
   Abidin, I
   Yulug, E
   Alver, A
AF Sahin, Elif
   Saglam, Neslihan
   Erdem, Seniz
   Alvuroglu, Elif
   Abidin, Ismail
   Yulug, Esin
   Alver, Ahmet
TI 7,8-Dihydroxyflavone alleviates Endoplasmic Reticulum Stress in
   cafeteria diet-induced metabolic syndrome
SO LIFE SCIENCES
LA English
DT Article
DE Insulin resistance; Liver; Pancreas; Inflammation; BDNF
ID UNFOLDED PROTEIN RESPONSE; OXIDATIVE STRESS; NEUROTROPHIC FACTOR;
   INDUCED OBESITY; ADIPOCYTE DIFFERENTIATION; ANTIOXIDANT ACTIVITY;
   INFLAMMATION; ACTIVATION; MODEL; TRKB
AB Aims: Prolonged Endoplasmic Reticulum Stress (ERS) is involved in the pathogenesis of metabolic syndrome, including type-2 diabetes mellitus, cardiovascular diseases, atherosclerosis, obesity, and fatty liver disease. There have been significant efforts to discover molecules to treat ERS and/or to ameliorate associate symptoms. In this study, we investigated the effect of 7,8-Dihydroxyflavone (7,8-DHF) on ERS in liver and pancreas tissues in a cafeteria (CAF) diet induced metabolic syndrome model.
   Main methods: Male C57BL/6 mice were fed CAF diet for 16 weeks and 7,8-DHF was administered intraperito-neally (5 mg/kg/day) for last four weeks. 78-kDa glucose-regulated protein (GRP78) and C/EBP homologous protein (CHOP) in liver and pancreas tissues, insulin and interleukin-113 (IL-113) in serum were analyzed by ELISA method and serum biochemistry parameters were analyzed with autoanalyzer. GRP78 and CHOP gene expression levels were determined by qRT-PCR. In addition, histopathological analyzes were performed on liver and pancreas tissues.
   Key findings: Findings revealed that CAF diet caused metabolic abnormalities, insulin resistance and inflamma-tion in serum and triggered ERS in pancreas and liver tissues. 7,8-DHF treatment significantly reduced metabolic abnormalities by reducing serum biochemical parameters, HOMO-IR and IL-113 levels. qRT-PCR and ELISA results indicated that 7,8-DHF treatment down-regulated GRP78 and CHOP expression and protein levels in the liver and GRP78 expression in pancreas. Efficiency of 7,8-DHF in these tissues was also demonstrated by histopath-ological tests. Significance: In conclusion, CAF diet-induced metabolic syndrome model, 7,8-DHF suppressed ERS and ERS-induced metabolic disorders in both liver and pancreas. Therefore, 7,8-DHF may potentially be a novel thera-peutic compound to ameliorate ERS and related metabolic symptoms.
C1 [Sahin, Elif; Saglam, Neslihan; Erdem, Seniz] Karadeniz Tech Univ, Grad Sch Med Sci, Dept Med Biochem, Trabzon, Turkey.
   [Alvuroglu, Elif; Yulug, Esin] Karadeniz Tech Univ, Fac Med, Dept Histol & Embryol, Trabzon, Turkey.
   [Abidin, Ismail] Karadeniz Tech Univ, Fac Med, Dept Biophys, Trabzon, Turkey.
   [Alver, Ahmet] Karadeniz Tech Univ, Fac Med, Dept Med Biochem, Trabzon, Turkey.
C3 Karadeniz Technical University; Karadeniz Technical University;
   Karadeniz Technical University; Karadeniz Technical University
RP Sahin, E (corresponding author), Karadeniz Tech Univ, Grad Sch Med Sci, Dept Med Biochem, Trabzon, Turkey.
EM elifsahin@ktu.edu.tr
RI SAĞLAM, NESLİHAN/AAK-4588-2021; ERDEM, ŞENİZ/AAR-2145-2020; Yuluğ,
   Esin/AAK-2077-2021; Şahin, Elif/AAR-4147-2020; abidin,
   ismail/AAR-2152-2020; Alver, Ahmet/AAH-4599-2021
OI Alver, Ahmet/0000-0002-9617-6689; Sahin, Elif/0000-0001-5864-9548;
   ERDEM, SENIZ/0000-0001-5643-3057; abidin, ismail/0000-0003-2510-9718
FU Scientific Research Projects Coordination Unit at the Karadeniz
   Technical University [TDK-2020-8738, THD-2021-9366]
FX This study was supported by the Scientific Research Projects
   Coordination Unit at the Karadeniz Technical University (Project
   Numbers: TDK-2020-8738 and THD-2021-9366).
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NR 64
TC 5
Z9 5
U1 3
U2 24
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0024-3205
EI 1879-0631
J9 LIFE SCI
JI Life Sci.
PD OCT 1
PY 2022
VL 306
AR 120781
DI 10.1016/j.lfs.2022.120781
EA JUL 2022
PG 11
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA 4N4PV
UT WOS:000854002300003
PM 35835252
DA 2025-06-11
ER

PT J
AU Lim, TK
   Noman, A
   Choy, AMJ
   Khan, F
   Struthers, AD
   Lang, CC
AF Lim, Tiong Keng
   Noman, Awson
   Choy, Anna Maria J.
   Khan, Faisel
   Struthers, Allan D.
   Lang, Chim C.
TI The APEX trial: Effects of allopurinol on exercise capacity, coronary
   and peripheral endothelial function, and natriuretic peptides in
   patients with cardiac syndrome X
SO CARDIOVASCULAR THERAPEUTICS
LA English
DT Article
DE allopurinol; cardiac syndrome X; exercise; oxidative stress
ID ARTERY-DISEASE; CHEST-PAIN; WOMEN; DYSFUNCTION; PROGNOSIS; ISCHEMIA
AB The role of endothelial dysfunction and oxidative stress in the pathogenesis of cardiac syndrome X has recently been recognized. Allopurinol has previously been shown to improve endothelial dysfunction, reduce oxidative stress burden, and improve myocardial efficiency. In this proof of concept study, we investigated the effect of allopurinol on exercise capacity, coronary and peripheral endothelial function, and serum B-type natriuretic peptide (BNP: a marker of cardiac function and myocardial ischemia) in patients with cardiac syndrome X.
   Methods and ResultsThis study was a randomized, double-blind, placebo-control crossover trial. Nineteen patients (mean age 5910years, 11 women and 8 men) with cardiac syndrome X were randomized to a 6-week treatment with either allopurinol (600mg/day) or placebo. After 4weeks of washout period, they were crossed over to the other arm. Outcomes measured at baseline and after treatment were maximum exercise time (ET) derived from Bruce protocol exercise treadmill test, serum BNP measurement, coronary flow reserve (CFR) as assessed by measuring the response of flow velocity in the left anterior descending artery to adenosine, and flow-mediated vasodilatation of the brachial artery (FMD). Allopurinol significantly reduced serum uric acid levels when compared with placebo (-48 +/- 24% vs 1.9 +/- 11%, P<.001). There was no significant difference in maximum ET, CFR, and FMD between allopurinol and placebo. However, there was a trend that allopurinol reduced serum BNP when compared to placebo (-8% [interquartile range -22% to 65%] vs 44% [interquartile range -18% to 140%]; P=.07).
   ConclusionIn patients with cardiac syndrome X, high-dose allopurinol did not improve exercise capacity, and coronary or peripheral endothelial function.
C1 [Lim, Tiong Keng] Natl Heart Ctr Singapore, Singapore, Singapore.
   [Noman, Awson] Aberdeen Royal Infirm, Aberdeen, Scotland.
   [Choy, Anna Maria J.; Khan, Faisel; Struthers, Allan D.; Lang, Chim C.] Univ Dundee, Ninewells Hosp & Med Sch, Div Mol & Clin Med, Dundee, Scotland.
C3 National Heart Centre Singapore; University of Aberdeen; University of
   Dundee
RP Lang, CC (corresponding author), Univ Dundee, Ninewells Hosp & Med Sch, Div Mol & Clin Med, Dundee, Scotland.
EM c.c.lang@dundee.ac.uk
RI Lang, Chim/JFJ-8074-2023; Choy, AnnaMaria/MZR-9039-2025
OI Lang, Chim/0000-0002-4530-3078; Choy, Anna Maria/0000-0002-4052-0591;
   Khan, Faisel/0000-0002-9889-0229
FU British Heart Foundation [PG/07/051/23063]
FX British Heart Foundation, Grant/Award Number: PG/07/051/23063
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NR 14
TC 10
Z9 10
U1 0
U2 2
PU WILEY-HINDAWI
PI LONDON
PA ADAM HOUSE, 3RD FL, 1 FITZROY SQ, LONDON, WIT 5HE, ENGLAND
SN 1755-5914
EI 1755-5922
J9 CARDIOVASC THER
JI Cardiovasc. Ther.
PD FEB
PY 2018
VL 36
IS 1
AR e12311
DI 10.1111/1755-5922.12311
PG 6
WC Cardiac & Cardiovascular Systems; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Pharmacology & Pharmacy
GA FS3LY
UT WOS:000419684600005
PM 29080386
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Chudleigh, J
   Barben, J
   Ren, CL
   Southern, KW
AF Chudleigh, Jane
   Barben, Juerg
   Ren, Clement L.
   Southern, Kevin W.
TI International Approaches to Management of CFTR-Related Metabolic
   Syndrome/Cystic Fibrosis Screen Positive, Inconclusive Diagnosis
SO INTERNATIONAL JOURNAL OF NEONATAL SCREENING
LA English
DT Article
DE cystic fibrosis; newborn bloodspot screening; CFTR-related metabolic
   syndrome; cystic fibrosis screen positive; inconclusive diagnosis
ID CYSTIC-FIBROSIS; SICKLE-CELL; PARENTS; PERFORMANCE; DISORDERS
AB The main aim of the present study was to explore health professionals' reported experiences and approaches to managing children who receive a designation of cystic fibrosis transmembrane conductance regulator-related metabolic syndrome/cystic fibrosis screen positive inconclusive diagnosis following a positive NBS result for cystic fibrosis. An online questionnaire was distributed via Qualtrics Survey Software and circulated to a purposive, international sample of health professionals involved in managing children with this designation. In total, 101 clinicians completed the online survey: 39 from the US, six from Canada, and 56 from Europe (including the UK). Results indicated that while respondents reported minor deviations in practice, they were cognizant of recommendations in the updated guidance and for the most part, attempted to implement these into practice consistently internationally. Where variation was reported, the purpose of this appeared to be to enable clinicians to respond to either clinical assessments or parental anxiety in order to improve outcomes for the child and family. Further research is needed to determine if these findings are reflective of both a wider audience of clinicians and actual (rather than reported) practice.
C1 [Chudleigh, Jane] City Univ London, Sch Hlth Sci, London EC1V 0HB, England.
   [Barben, Juerg] Childrens Hosp Eastern Switzerland, CH-9000 St Gallen, Switzerland.
   [Ren, Clement L.] Childrens Hosp Philadelphia, Philadelphia, PA 19104 USA.
   [Southern, Kevin W.] Univ Liverpool, Dept Womens & Childrens Hlth, Liverpool L69 3BX, Merseyside, England.
C3 City St Georges, University of London; City, University of London;
   University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of
   Philadelphia; University of Liverpool
RP Chudleigh, J (corresponding author), City Univ London, Sch Hlth Sci, London EC1V 0HB, England.
EM j.chudleigh@city.ac.uk; Juerg.Barben@kispisg.ch; renc@chop.edu;
   kwsouth@liv.ac.uk
RI Ren, Clement/AFW-0625-2022
CR Barben J, 2021, J CYST FIBROS, V20, P810, DOI 10.1016/j.jcf.2020.11.006
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NR 30
TC 6
Z9 6
U1 0
U2 0
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2409-515X
J9 INT J NEONAT SCREEN
JI Int. J. Neonatal Screen.
PD MAR
PY 2022
VL 8
IS 1
AR 5
DI 10.3390/ijns8010005
PG 11
WC Genetics & Heredity; Pediatrics
WE Emerging Sources Citation Index (ESCI)
SC Genetics & Heredity; Pediatrics
GA 0C4QW
UT WOS:000775300800001
PM 35076474
OA Green Published, gold, Green Accepted
DA 2025-06-11
ER

PT J
AU Töpfer, P
   Siewert-Markus, U
   Klinger-König, J
   Grabe, HJ
   Stracke, S
   Dörr, M
   Völzke, H
   Ittermann, T
   Markus, MRP
AF Toepfer, Philipp
   Siewert-Markus, Ulrike
   Klinger-Koenig, Johanna
   Grabe, Hans J.
   Stracke, Sylvia
   Doerr, Marcus
   Voelzke, Henry
   Ittermann, Till
   Markus, Marcello R. P.
TI Sex-specific associations of childhood maltreatment with obesity-related
   traits - The Study of Health in Pomerania (SHIP)
SO CHILD ABUSE & NEGLECT
LA English
DT Article
DE Child maltreatment; Long-term risk; Sex differences; Obesity; Body fat;
   Cardiometabolic risk
ID PHYSICAL ABUSE; ADULT OBESITY; EXPERIENCES; TRAUMA; OVERWEIGHT;
   DEPRESSION; STRESS; WOMEN
AB Background: Child maltreatment (CM) is linked to obesity in adulthood. However, sex-differences and direct measurements of body fat have previously been insufficiently considered in this context. Objective: To assess sex-specific associations of CM with anthropometric markers of overweight/ obesity and direct measures of body fat. Participants and setting: Analyses were conducted in 4006 adults from a population-based cohort in Northeastern Germany (SHIP-TREND-0). Methods: CM was assessed using the Childhood Trauma Questionnaire (CTQ). Obesity-related traits included anthropometric indicators (i.e., height, weight, body mass index [BMI], waist [WC] and hip circumference [HC], waist-to-hip ratio [WHR], waist-to-height ratio [WHtR]), fat mass (FM) and fat-free mass (FFM) derived from bioelectrical impedance analysis (BIA), and subcutaneous (SAT) and visceral adipose tissue (VAT) ascertained using magnetic resonance imaging (MRI). Sex-stratified linear regression models predicting obesity-related traits from total CTQ scores were adjusted for age and education. Exploratory analyses investigated effects of CTQ subscales on obesity-related traits. Results: In men, CM was positively associated with WHtR (8 = 0.04; p = .030) and VAT (8 = 0.02; p = .031) and inversely with body height (8 = -0.05; p = .010). In women, CM-exposure was positively associated with body weight (8 = 0.07; p = .018), BMI (8 = 0.03; p = .013), WC (8 = 0.07; p = .005), HC (8 = 0.05; p = .046), WHR (8 = 0.03; p = .015), WHtR (8 = 0.04; p = .006), FM (8 = 0.04; p = .006), and SAT (8 = 0.06; p = .041). In both sexes, effects were mainly driven by exposure to emotional and physical abuse. Conclusions: Results suggest that associations between CM -exposure and obesity -related traits in adulthood are primarily present in women. This may have implications for sex -specific obesity - related cardiometabolic risk after CM.
C1 [Toepfer, Philipp; Siewert-Markus, Ulrike] Univ Med Greifswald, Dept Med Psychol, Greifswald, Germany.
   [Klinger-Koenig, Johanna; Grabe, Hans J.] Univ Med Greifswald, Dept Psychiat & Psychotherapy, Greifswald, Germany.
   [Grabe, Hans J.] German Ctr Neurodegenerat Dis DZNE, Site Rostock, Greifswald, Germany.
   [Stracke, Sylvia] Univ Med Greifswald, Dept Internal Med, Greifswald, Germany.
   [Doerr, Marcus; Markus, Marcello R. P.] Univ Med Greifswald, Dept Internal Med B, Greifswald, Germany.
   [Doerr, Marcus; Ittermann, Till; Markus, Marcello R. P.] German Ctr Cardiovasc Res DZHK, Partner Site Greifswald, Greifswald, Germany.
   [Voelzke, Henry; Ittermann, Till] Univ Med Greifswald, Inst Community Med, Dept Study Hlth Pomerania, Clin Epidemiol Res, Greifswald, Germany.
   [Markus, Marcello R. P.] German Ctr Diabet Res DZD, Partner Site Greifswald, Greifswald, Germany.
C3 Universitat Greifswald; Greifswald Medical School; Universitat
   Greifswald; Greifswald Medical School; Helmholtz Association; German
   Center for Neurodegenerative Diseases (DZNE); Universitat Greifswald;
   Greifswald Medical School; Universitat Greifswald; Greifswald Medical
   School; German Centre for Cardiovascular Research; Universitat
   Greifswald; Greifswald Medical School; German Center for Diabetes
   Research (DZD)
RP Töpfer, P (corresponding author), Univ Med Greifswald, Dept Med Psychol, Greifswald, Germany.
EM philipp.toepfer@med.uni-greifswald.de
RI Stracke, Sylvia/ABB-8871-2020; Markus, Marcello/H-7698-2019
OI Topfer, Philipp/0000-0002-0041-6538; Stracke, Sylvia/0000-0001-6200-4339
FU Federal Ministry of Education and Research [01ZZ9603, 01ZZ0103,
   01ZZ0403]; Ministry of Cultural Affairs; Social Ministry of the Federal
   State of Mecklenburg-West Pomerania; Siemens Healthineers, Erlangen,
   Germany; Federal State of Mecklenburg-West Pomerania
FX SHIP is part of the Community Medicine Research net of the University of
   Greifswald, Germany, which is funded by the Federal Ministry of
   Education and Research (grants no. 01ZZ9603, 01ZZ0103, and 01ZZ0403),
   the Ministry of Cultural Affairs as well as the Social Ministry of the
   Federal State of Mecklenburg-West Pomerania. MRI scans in SHIP and
   SHIP-TREND have been supported by a joint grant from Siemens
   Healthineers, Erlangen, Germany and the Federal State of
   Mecklenburg-West Pomerania.
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NR 48
TC 3
Z9 3
U1 0
U2 1
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0145-2134
EI 1873-7757
J9 CHILD ABUSE NEGLECT
JI Child Abuse Negl.
PD MAR
PY 2024
VL 149
AR 106704
DI 10.1016/j.chiabu.2024.106704
EA FEB 2024
PG 11
WC Family Studies; Psychology, Social; Social Work
WE Social Science Citation Index (SSCI)
SC Family Studies; Psychology; Social Work
GA NR8O4
UT WOS:001202273800001
PM 38395019
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Gur, M
   Yildiz, A
   Demirbag, R
   Yilmaz, R
   Koçyigit, A
   Aksoy, N
AF Gur, Mustafa
   Yildiz, Ali
   Demirbag, Recep
   Yilmaz, Remzi
   Kocyigit, Abdurrahim
   Aksoy, Nurten
TI Increased lymphocyte deoxyribonucleic acid damage in patients with
   cardiac syndrome X
SO MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
LA English
DT Article
DE DNA damage; cardiac syndrome X; total antioxidant status; oxidative
   stress; inflammation; comet assay
ID CORONARY-ARTERY-DISEASE; OXIDATIVE DNA-DAMAGE; ELEVATED LEVELS;
   INFLAMMATORY DISEASE; ANTIOXIDANT STATUS; ANGINA-PECTORIS; COMET ASSAY;
   ATHEROSCLEROSIS; MECHANISMS; PLASMA
AB Objectives: To investigate whether there is lymphocyte deoxyribonucleic acid (DNA) damage in patients with cardiac syndrome X (CSX), and its relation with total antioxidant status (TAS), inflammation and ischemia.
   Methods: Twenty-three patients with CSX, 21 patients with non-CSX (NCSX) and 20 healthy volunteers were included in the study. Lymphocyte DNA damage (Arbitrary Unit) was assessed by alkaline single cell electrophoresis (comet) assay in peripheral lymphocyte, and plasma levels of TAS (mmol Trolox equiv/l) were determined using a novel automated measurement method. High sensitive C-reactive protein (hsCRP) and other biochemical parameters were measured from all subjects. Treadmill exercise test and coronary angiography were performed to CSX and NCSX groups.
   Results: Lymphocyte DNA damage was increased in patients with CSX compared with NCSX and control group (p < 0.001, for both). Also, TAS was decreased, and hsCRP was increased in CSX compared with NCSX and control group (p < 0.00 1, for all). Lymphocyte DNA damage was correlated with magnitude of ST depression (p = 0.034), hsCRP (p = 0.001), TAS (p < 0.001) and presence of diabetes (p = 0.022) in bivariate analysis. In multiple linear regression analysis, lymphocyte DNA damage was correlated with only TAS (P = -0.413, p = 0.017) and hsCRP (P = 0.414, p = 0.006).
   Conclusion: Lymphocyte DNA damage was increased in patients with CSX. The increase in lymphocyte DNA damage may be related with increased oxidative stress and inflammation in patients with CSX. (c) 2006 Elsevier BX All rights reserved.
C1 Harran Univ, Fac Med, Dept Cardiol, Sanliurfa, Turkey.
   Harran Univ, Fac Med, Dept Clin Biochem, Sanliurfa, Turkey.
C3 Harran University; Harran University
RP Gur, M (corresponding author), PK-112, Sanliurfa, Turkey.
EM drmugur@yahoo.com
RI Inan, Nurten/AAA-8197-2021; Kocyigit, Abdurrahim/P-8685-2019; Demirbag,
   Recep/Z-2369-2019
OI Demirbag, Recep/0000-0001-7831-2715
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NR 31
TC 16
Z9 16
U1 0
U2 3
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0027-5107
J9 MUTAT RES-FUND MOL M
JI Mutat. Res.-Fundam. Mol. Mech. Mutagen.
PD APR 1
PY 2007
VL 617
IS 1-2
BP 8
EP 15
DI 10.1016/j.mrfmmm.2006.08.012
PG 8
WC Biotechnology & Applied Microbiology; Genetics & Heredity; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Genetics & Heredity; Toxicology
GA 159XK
UT WOS:000245901000002
PM 17261316
DA 2025-06-11
ER

PT J
AU Basu, A
   Wilkinson, M
   Penugonda, K
   Simmons, B
   Betts, NM
   Lyons, TJ
AF Basu, Arpita
   Wilkinson, Marci
   Penugonda, Kavitha
   Simmons, Brandi
   Betts, Nancy M.
   Lyons, Timothy J.
TI Freeze-dried strawberry powder improves lipid profile and lipid
   peroxidation in women with metabolic syndrome: baseline and post
   intervention effects
SO NUTRITION JOURNAL
LA English
DT Article
ID OXIDATIVE STRESS; ELLAGIC ACID; CARDIOVASCULAR-DISEASE; CHOLESTEROL;
   HUMANS; RISK; ATHEROSCLEROSIS; BIOAVAILABILITY; EXPRESSION; REDUCTION
AB Background: Strawberry flavonoids are potent antioxidants and anti-inflammatory agents that have been shown to reduce cardiovascular disease risk factors in prospective cohort studies. Effects of strawberry supplementation on metabolic risk factors have not been studied in obese populations. We tested the hypothesis that freeze-dried strawberry powder (FSP) will lower fasting lipids and biomarkers of oxidative stress and inflammation at four weeks compared to baseline. We also tested the tolerability and safety of FSP in subjects with metabolic syndrome. FSP is a concentrated source of polyphenolic flavonoids, fiber and phytosterols.
   Methods: Females (n = 16) with 3 features of metabolic syndrome ( waist circumference >35 inches, triglycerides >150 mg/dL, fasting glucose >100 mg/dL and < 126 mg/dL, HDL < 50 mg/dL, or blood pressure > 130/85 mm Hg) were enrolled in the study. Subjects consumed two cups of the strawberry drink daily for four weeks. Each cup had 25 g FSP blended in water. Fasting blood draws, anthropometrics, dietary analyses, and blood pressure measurements were done at baseline and 4 weeks. Biomarkers of oxidative stress and inflammation were measured using ELISA techniques. Plasma ellagic acid was measured using HPLC-UV techniques.
   Results: Total cholesterol and LDL-cholesterol levels were significantly lower at 4 weeks versus baseline (-5% and -6%, respectively, p < 0.05), as was lipid peroxidation in the form of malondialdehyde and hydroxynonenal (-14%, p < 0.01). Oxidized-LDL showed a decreasing trend at 4 weeks ( p = 0.123). No effects were noted on markers of inflammation including C-reactive protein and adiponectin. A significant number of subjects (13/16) showed an increase in plasma ellagic acid at four weeks versus baseline, while no significant differences were noted in dietary intakes at four weeks versus baseline. Thus, short-term supplementation of freeze-dried strawberries appeared to exert hypocholesterolemic effects and decrease lipid peroxidation in women with metabolic syndrome.
C1 [Basu, Arpita; Wilkinson, Marci; Penugonda, Kavitha; Simmons, Brandi; Betts, Nancy M.] Oklahoma State Univ, Dept Nutr Sci, Stillwater, OK 74078 USA.
   [Lyons, Timothy J.] Univ Oklahoma, Hlth Sci Ctr, Harold Hamm Oklahoma Diabet Ctr, Oklahoma City, OK 73104 USA.
C3 Oklahoma State University System; Oklahoma State University -
   Stillwater; University of Oklahoma System; University of Oklahoma Health
   Sciences Center
RP Basu, A (corresponding author), Oklahoma State Univ, Dept Nutr Sci, 301 Human Environm Sci, Stillwater, OK 74078 USA.
EM arpita.basu@okstate.edu; marci.wilkinson@okstate.edu;
   kavitha.penugonda@okstate.edu; brandi.simmons@okstate.edu;
   nancy.betts@okstate.edu; timothy-lyons@ouhsc.edu
RI Penugonda, Kavitha/AGJ-0190-2022
OI Penugonda, Kavitha/0000-0002-7649-5404; Lyons,
   Timothy/0000-0003-2106-1622
CR Bachman JL, 2008, J AM DIET ASSOC, V108, P804, DOI 10.1016/j.jada.2008.02.026
   *CA STRAWB COMM, 2009, HLTH NUTR 2009
   Carkeet C, 2008, J NUTR, V138, P897, DOI 10.1093/jn/138.5.897
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NR 26
TC 127
Z9 145
U1 0
U2 23
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1475-2891
J9 NUTR J
JI Nutr. J.
PD SEP 28
PY 2009
VL 8
AR 43
DI 10.1186/1475-2891-8-43
PG 7
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 508YJ
UT WOS:000270974900001
PM 19785767
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Cui, Y
   Prabhu, VV
   Nguyen, TB
   Devi, SM
   Chung, YC
AF Cui, Yin
   Prabhu, Vishwanath Vasudev
   Thong Ba Nguyen
   Devi, Subramaniam Mohana
   Chung, Young-Chul
TI Longer Telomere Length of T lymphocytes in Patients with Early and
   Chronic Psychosis
SO CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE
LA English
DT Article
DE Antipsychotic agents; Telomere length; Telomerase; T lymphocytes;
   Psychosis; Quantitative Real-time PCR
ID DOPAMINE-D-2 RECEPTOR OCCUPANCY; SCHIZOPHRENIA; RISPERIDONE; STRESS;
   NAIVE; ANTIPSYCHOTICS; DISORDERS; CLOZAPINE; EROSION; DISEASE
AB Objective: To investigate pathological conditions that act as sources of pro-inflammatory cytokines and cytotoxic substances to examine telomere length (TL) in patients with either early (duration of illness [DI] <= 5 years) or chronic (DI > 5 years) psychosis using T lymphocytes.
   Methods: Based on these factors and the important role that T lymphocytes play in inflammation, the present study measured the TL of T lymphocytes in patients with either early or chronic psychosis. Additionally, smoking, metabolic syndrome, depression, and cognitive functioning were assessed to control for confounding effects.
   Results: TL was significantly longer in patients with early and chronic psychosis than in healthy control subjects and, moreover, the significance of these findings remained after controlling for age, smoking, metabolic syndrome, DI, chlorpromazine-equivalent dose, and cognitive functioning (F=9.57, degree of freedom= 2, p<0.001). Additionally, the DI, chlorpromazine-equivalent doses, and the five-factor scores of the Positive and Negative Syndrome Scale were not significantly correlated with the TL of T lymphocytes in either all patients or each psychosis group.
   Conclusion: Possible mechanisms underlying the effects of antipsychotic medications on telomerase are discussed in the present study, but further studies measuring both telomerase activity and TL using a prospective design will be required.
C1 [Cui, Yin; Prabhu, Vishwanath Vasudev; Thong Ba Nguyen; Devi, Subramaniam Mohana; Chung, Young-Chul] Chonbuk Natl Univ, Med Sch, Dept Psychiat, 20 Geonji Ro, Jeonju 54907, South Korea.
   [Cui, Yin; Prabhu, Vishwanath Vasudev; Thong Ba Nguyen; Devi, Subramaniam Mohana; Chung, Young-Chul] Chonbuk Natl Univ, Chonbuk Natl Univ Hosp, Res Inst Clin Med, Biomed Res Inst, Jeonju, South Korea.
C3 Jeonbuk National University; Jeonbuk National University; Jeonbuk
   National University Hospital
RP Chung, YC (corresponding author), Chonbuk Natl Univ, Med Sch, Dept Psychiat, 20 Geonji Ro, Jeonju 54907, South Korea.
EM chungyc@jbnu.ac.kr
RI Prabhu, Vishwanath/AAA-1472-2021; Nguyen, Ba Thong/ADQ-2780-2022
OI Nguyen, Ba Thong/0000-0001-9647-534X
FU Korean Health Technology R&D Project, Ministry of Health & Welfare,
   Republic of Korea [HI13C1459]
FX This study was supported by a grant from the Korean Health Technology
   R&D Project, Ministry of Health & Welfare, Republic of Korea
   (HI13C1459). The author would like to thank all the participants in the
   study and the Heavenly Father who guides along the right pathway. The
   authors report no biomedical financial interests or potential conflicts
   of interest.
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NR 55
TC 13
Z9 14
U1 0
U2 8
PU KOREAN COLL NEUROPSYCHOPHARMACOLOGY
PI SEOUL
PA RN 1003 OFFICETEL 40, 63-RO YEONGDEUNGPO-GU, SEOUL, 150-731, SOUTH KOREA
SN 1738-1088
EI 2093-4327
J9 CLIN PSYCHOPHARM NEU
JI Clin. Psychopharmacol. Neurosci.
PD MAY
PY 2017
VL 15
IS 2
BP 146
EP 152
DI 10.9758/cpn.2017.15.2.146
PG 7
WC Neurosciences; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pharmacology & Pharmacy
GA EV1TT
UT WOS:000401531000007
PM 28449562
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Kim, HB
   Wolf, BJ
   Kim, JH
AF Kim, Hong-Bae
   Wolf, Bethany J.
   Kim, Jung-Ha
TI Association of metabolic syndrome and its components with the risk of
   depressive symptoms: A systematic review and meta-analysis of cohort
   studies
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Metabolic syndrome; Depressive symptoms; Observational cohort study;
   meta -analysis
ID OLDER-ADULTS; ANXIETY; HEALTH; COMORBIDITY; PREVALENCE; MECHANISMS;
   DISORDER; DISEASE; OBESITY; YOUNG
AB Background: The purpose of this meta-analysis was to quantitatively analyze the association between metabolic syndrome (MetS) and the risk of depressive symptoms.Methods: Three electronic databases (PubMed, Embase, and PsycINFO) were searched for articles published through February 15, 2022. Cohort studies evaluating the association between MetS and depressive symptoms were selected for inclusion in this study. A random-effects model was used to evaluate the pooled estimates of MetS, including each of its components, associated with depressive symptoms.Results: A total of 11 cohort studies were selected including >2.65 million participants. There was a significant association between MetS and depressive symptoms risk, albeit with a high degree of heterogeneity (relative risk = 1.29, 95 % confidence interval: 1.12-1.48; I2 = 79.3 %). This association was consistently significant in Western countries, but it was not significant in Asian countries. When stratified by sex, age, and geographical region, MetS and its components exhibited varying degrees of association with depressive symptoms.Conclusions: MetS is a risk factor for depressive symptoms. Further large-scale prospective cohort studies are required to confirm our findings.
C1 [Wolf, Bethany J.] Hanyang Univ, Myongji Hosp, Coll Med, Dept Family Med, Goyang, South Korea.
   [Kim, Jung-Ha] Med Univ South Carolina, Dept Publ Hlth Sci, Charleston, SC USA.
   [Kim, Jung-Ha] Chung Ang Univ, Med Ctr, Coll Med, Dept Family Med, Seoul, South Korea.
   [Kim, Jung-Ha] Chung Ang Univ, Dept Family Med, Med Ctr, 102 Heukseok ro, Seoul 06973, South Korea.
C3 Hanyang University; Myongji Hospital; Medical University of South
   Carolina; Chung Ang University; Chung Ang University Hospital; Chung Ang
   University; Chung Ang University Hospital
RP Kim, JH (corresponding author), Chung Ang Univ, Dept Family Med, Med Ctr, 102 Heukseok ro, Seoul 06973, South Korea.
EM girlpower219@cau.ac.kr
RI Kim, Eun-Ji/HHN-4611-2022
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NR 55
TC 9
Z9 10
U1 1
U2 8
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD FEB 15
PY 2023
VL 323
BP 46
EP 54
DI 10.1016/j.jad.2022.11.049
EA NOV 2022
PG 9
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA 8A1YK
UT WOS:000916041300007
PM 36427648
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Patil, R
   Aswar, U
   Vyas, N
AF Patil, Rashmi
   Aswar, Urmila
   Vyas, Nishant
TI Pterostilbene alleviates cafeteria diet-induced obesity and underlying
   depression in adolescent male Swiss albino mice and affects insulin
   resistance, inflammation, HPA axis dysfunction and SIRT1 mediated
   leptin-ghrelin signaling
SO HORMONES AND BEHAVIOR
LA English
DT Article
DE Adolescent; Cafeteria diet; Depression; Inflammation; Insulin
   resistance; Obesity
ID TUMOR-NECROSIS-FACTOR; UNPREDICTABLE MILD STRESS; BLOOD-BRAIN-BARRIER;
   OXIDATIVE STRESS; METABOLIC SYNDROME; ADIPOSE-TISSUE; FACTOR-ALPHA;
   LIFE-STYLE; MODEL; RATS
AB Cafeteria diet (CD) model for in -vivo studies mimics the western diet having imbalanced nutritional value, high caloric -density and palatability. Uncontrolled eating leads to the development of childhood obesity, poor selfesteem and depression due to its effects on brain development. Herbal supplements are novel inclusion in the management of obesity and mental well-being. Pterostilbene (PTE) found in blueberries and Pterocarpus marsupium heartwood, is known to prevent obesity in invivo models. Adolescent Swiss albino male mice were fed on CD for 70 days and the development of obesity was assessed by gain in body weight, abdominal circumference. Forced swim and tail suspension test confirmed depression in CD fed mice. Obesity induced depressed (OID) mice were treated with PTE (10, 20, 40 mg/kg), standard antiobesity drug cetilistat (10 mg/kg), antidepressant fluoxetine (10 mg/kg) for 28 days. Post treatment, PTE -treated mice showed reduction in BW and depression -like behavior analysed using paradigms such as sucrose preference, open field, marble burying, and resident intruder test in comparison to the CD group. Insulin resistance, lipid profile, antioxidant enzyme, inflammatory cytokines (NF-kappa B, IL -6, TNF alpha) and cortisol levels were mitigated by PTE. It also restored normal cellular architecture of the brain and adipose tissue and increased the Silent mating type information regulation 2 homolog1 (SIRT1), leptin and ghrelin receptors gene expression in the brain. Thus, it can be concluded that PTE might have inhibited OID like behavior in mice via inhibition of IR, modulating neuroinflammation and hypothalamic-pituitary-adrenal axis dysfunction and upregulating SIRT1 mediated leptin-ghrelin signaling.
C1 [Patil, Rashmi; Aswar, Urmila] Bharati Vidyapeeth, Poona Coll Pharm, Pune 411038, Maharashtra, India.
   [Vyas, Nishant] Log Life Sci Pvt Ltd, Pune, India.
C3 Bharati Vidyapeeth Deemed University; Poona College of Pharmacy
RP Aswar, U (corresponding author), Bharati Vidyapeeth, Poona Coll Pharm, Pune 411038, Maharashtra, India.
EM urmila.aswar@bharatividyapeeth.edu
RI ; Aswar, Urmila/ABR-9481-2022
OI Patil, Rashmi/0000-0002-0032-9418; Aswar, Urmila/0000-0002-4566-7453
FU Babasaheb Ambedkar National Research Fellowship (BANRF) , India [849]
FX This work was supported by Babasaheb Ambedkar National Research
   Fellowship (BANRF) , India (Award letter no-849) .
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NR 102
TC 4
Z9 5
U1 3
U2 3
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0018-506X
EI 1095-6867
J9 HORM BEHAV
JI Horm. Behav.
PD MAY
PY 2024
VL 161
AR 105504
DI 10.1016/j.yhbeh.2024.105504
EA FEB 2024
PG 15
WC Behavioral Sciences; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Behavioral Sciences; Endocrinology & Metabolism
GA LA8G1
UT WOS:001184141400001
PM 38354494
DA 2025-06-11
ER

PT J
AU Bourebaba, L
   Serwotka-Suszczak, A
   Pielok, A
   Sikora, M
   Mularczyk, M
   Marycz, K
AF Bourebaba, Lynda
   Serwotka-Suszczak, Anna
   Pielok, Ariadna
   Sikora, Mateusz
   Mularczyk, Malwina
   Marycz, Krzysztof
TI The PTP1B inhibitor MSI-1436 ameliorates liver insulin sensitivity by
   modulating autophagy, ER stress and systemic inflammation in Equine
   metabolic syndrome affected horses
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Article
DE EMS; PTP1B; MSI-1436; liver metabolism; autophagy; insulin; inflammation
ID TYROSINE-PHOSPHATASE 1B; ENDOPLASMIC-RETICULUM STRESS; LINKS OBESITY;
   RESISTANCE; ACTIVATION; DEPHOSPHORYLATION; DYSFUNCTION; RECEPTOR; CELLS;
   ADIPOCYTES
AB BackgroundEquine metabolic syndrome (EMS) is a multifactorial pathology gathering insulin resistance, low-grade inflammation and past or chronic laminitis. Among the several molecular mechanisms underlying EMS pathogenesis, increased negative insulin signalling regulation mediated by protein tyrosine phosphatase 1 B (PTP1B) has emerged as a critical axis in the development of liver insulin resistance and general metabolic distress associated to increased ER stress, inflammation and disrupted autophagy. Thus, the use of PTP1B selective inhibitors such as MSI-1436 might be considered as a golden therapeutic tool for the proper management of EMS and associated conditions. Therefore, the present investigation aimed at verifying the clinical efficacy of MSI-1436 systemic administration on liver metabolic balance, insulin sensitivity and inflammatory status in EMS affected horses. Moreover, the impact of MSI-1436 treatment on liver autophagy machinery and associated ER stress in liver tissue has been analysed. MethodsLiver explants isolated from healthy and EMS horses have been treated with MSI-1436 prior to gene and protein expression analysis of main markers mediating ER stress, mitophagy and autophagy. Furthermore, EMS horses have been intravenously treated with a single dose of MSI-1436, and evaluated for their metabolic and inflammatory status. ResultsClinical application of MSI-1436 to EMS horses restored proper adiponectin levels and attenuated the typical hyperinsulinemia and hyperglycemia. Moreover, administration of MSI-1436 further reduced the circulating levels of key pro-inflammatory mediators including IL-1 beta, TNF-alpha and TGF-beta and triggered the Tregs cells activation. At the molecular level, PTP1B inhibition resulted in a noticeable mitigation of liver ER stress, improvement of mitochondrial dynamics and consequently, a regulation of autophagic response. Similarly, short-term ex vivo treatment of EMS liver explants with trodusquemine (MSI-1436) substantially enhanced autophagy by upregulating the levels of HSC70 and Beclin-1 at both mRNA and protein level. Moreover, the PTP1B inhibitor potentiated mitophagy and associated expression of MFN2 and PINK1. Interestingly, inhibition of PTP1B resulted in potent attenuation of ER stress key mediators' expression namely, CHOP, ATF6, HSPA5 and XBP1. ConclusionPresented findings shed for the first time promising new insights in the development of an MSI-1436-based therapy for proper equine metabolic syndrome intervention and may additionally find potential translational application to human metabolic syndrome treatment.
C1 [Bourebaba, Lynda; Serwotka-Suszczak, Anna; Pielok, Ariadna; Sikora, Mateusz; Mularczyk, Malwina; Marycz, Krzysztof] Wroclaw Univ Environm & Life Sci, Fac Biol & Anim Sci, Dept Expt Biol, Wroclaw, Poland.
   [Bourebaba, Lynda; Mularczyk, Malwina] Int Inst Translat Med, Wiszn Mala, Poland.
   [Marycz, Krzysztof] Univ Calif Davis, Sch Vet Med, Dept Med & Epidemiol, Davis, CA 95616 USA.
C3 Wroclaw University of Environmental & Life Sciences; University of
   California System; University of California Davis
RP Marycz, K (corresponding author), Wroclaw Univ Environm & Life Sci, Fac Biol & Anim Sci, Dept Expt Biol, Wroclaw, Poland.; Marycz, K (corresponding author), Univ Calif Davis, Sch Vet Med, Dept Med & Epidemiol, Davis, CA 95616 USA.
EM krzysztof.marycz@upwr.edu.pl
RI Serwotka-Suszczak, Anna/L-7188-2019; Marycz, Krzysztof/A-2249-2017;
   Bourebaba, Lynda/AAX-7613-2020
FU National Science Centre in Poland [2018/29/B/NZ7/02662]; European Social
   Fund under the Operational Program Knowledge Education Development
   [POWR.03.05.00-00-Z062 / 18]
FX The work was supported by a research grant financed by the National
   Science Centre in Poland over the course of the realization of the
   project intitled: 'Inhibition of tyrosine phosphatase as a strategy to
   enhance insulin sensitivity through activation of chaperone mediated
   autophagy and amelioration of inflammation and cellular stress in the
   liver of equine metabolic syndrome (EMS) horses' (2018/29/B/NZ7/02662).
   The publication has been financed by the project "UPWR 2.0:international
   and interdisciplinary programme of development of Wroclaw University of
   Environmental and Life Sciences", co-financed by the European Social
   Fund under the Operational Program Knowledge Education Development,
   under contract No. POWR.03.05.00-00-Z062 / 18 of June 4, 2019.
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NR 100
TC 5
Z9 5
U1 4
U2 10
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD MAR 20
PY 2023
VL 14
AR 1149610
DI 10.3389/fendo.2023.1149610
PG 22
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA C4QN1
UT WOS:000961779000001
PM 37020593
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Abdelkader, C
   Cherif, FZH
   Elius, EAE
   Lucchesi, D
   Pucci, L
   Yahia, DA
AF Abdelkader, Chenni
   Cherif, Fatima Zohra Hamza
   Elius, Elif Ayse Erdogan
   Lucchesi, Daniela
   Pucci, Laura
   Yahia, Dalila Ait
TI Pumpkin seed proteins (Cucurbita pepo L.) protect against
   diet-induced metabolic syndrome by improving insulin resistance and
   markers of oxidative stress and inflammation in rats
SO BIOLOGIA
LA English
DT Article
DE Metabolic syndrome; Pumpkin seed proteins; Oxidative stress;
   Inflammation; Fructose; Rats
ID FATTY LIVER-DISEASE; CHAIN POLYUNSATURATED OMEGA-3; FRUIT EXTRACT;
   FRUCTOSE; STATE
AB Pumpkin (Cucurbita pepo L.) seeds are enriched in bioactive compounds having functional properties. The aim of this study was to analyze the pumpkin seed proteins (PSP) effects on insulin resistance, oxidative stress damage and inflammation in rats with high fructose-induced metabolic syndrome. Twenty four male Wistar rats, fed isoenergetic diets supplemented with: (1) 20% casein (C); (2) 20% casein and 1 g/kg/day PSP (P); (3) 20% casein and 64% D-fructose (C-HF); (4) 20% casein, 1 g/kg/day PSP and 64% D-fructose (P-HF). After 8 weeks of treatment, fructose supply impaired white adipose tissue (WAT) weight, deteriorated glucose tolerance and tAUC, plasma glucose, insulin, insulinogenic index, HOMA-IR and HOMA-beta, antioxidant status, lipid and protein oxidation, plasma TNF-alpha and IL-6 as compared to control diets. Interestingly, rats assigned to the PSPs diet with or without fructose displayed lower plasma glucose, insulin and fructose, improved tolerance of glucose, tAUC, HOMA-IR and HOMA-beta and increased insulinogenic index as compared to C diets. PSPs consumption lowered thiobarbituric acid reactive substances, hydroperoxides and carbonyls in WAT and carbonyls in muscle. Superoxide dismutase and glutathione peroxidase in WAT were significantly diminished in P-HF but increased in P as compared to C-HF and C. Rats fed P-HF diet had low catalase in WAT and high in muscle than those fed C-HF. Moreover, catalase activity increased in muscle but decreased in WAT in P group than in C group. In conclusion, pumpkin seed proteins exhibit favorable effects on metabolic disorders of fructose-induced metabolic syndrome, suggesting a key role in disease therapy.
C1 [Abdelkader, Chenni] Mohamed Boudiaf Univ USTO, Fac Sci Nat & Life, Dept Biol, Oran, Algeria.
   [Cherif, Fatima Zohra Hamza; Yahia, Dalila Ait] Univ Ahmed Ben Bella Oran1, Fac Sci Nat & Life, Dept Biol, Oran, Algeria.
   [Elius, Elif Ayse Erdogan] Mersin Univ, Tech Sci Vacat Sch, Dept Food Technol, TR-33343 Mersin, Turkey.
   [Lucchesi, Daniela] Univ Pisa, Dept Clin & Expt Med, Sect Diabet & Metab Dis, Pisa, Italy.
   [Pucci, Laura] Natl Res Council CNR, Inst Agr Biol & Biotechnol, Pisa, Italy.
C3 Mersin University; University of Pisa
RP Pucci, L (corresponding author), Natl Res Council CNR, Inst Agr Biol & Biotechnol, Pisa, Italy.
EM pucci@ibba.cnr.it
RI CHERIF, fatima-zahra/AAX-7596-2020; Pucci, Laura/AAU-4653-2020
OI Pucci, Laura/0000-0001-7063-6192
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NR 51
TC 3
Z9 3
U1 3
U2 22
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0006-3088
EI 1336-9563
J9 BIOLOGIA
JI Biologia
PD SEP
PY 2022
VL 77
IS 9
BP 2677
EP 2687
DI 10.1007/s11756-022-01112-9
EA JUN 2022
PG 11
WC Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics
GA 5V1ZL
UT WOS:000814039000001
OA hybrid
DA 2025-06-11
ER

PT J
AU Nelson, PA
   Kane, K
   Pearce, CJ
   Bundy, C
   Chisholm, A
   Hilton, R
   Thorneloe, R
   Young, H
   Griffiths, CEM
   Cordingley, L
AF Nelson, P. A.
   Kane, K.
   Pearce, C. J.
   Bundy, C.
   Chisholm, A.
   Hilton, R.
   Thorneloe, R.
   Young, H.
   Griffiths, C. E. M.
   Cordingley, L.
CA Identification Management Psoria
TI 'New to me': changing patient understanding of psoriasis and identifying
   mechanisms of change. The Pso Well® patient materials mixed-methods
   feasibility study
SO BRITISH JOURNAL OF DERMATOLOGY
LA English
DT Article
ID QUALITY-OF-LIFE; PSYCHOLOGICAL DISTRESS; ILLNESS PERCEPTIONS;
   SELF-MANAGEMENT; METABOLIC SYNDROME; PHYSICAL-ACTIVITY; HOSPITAL
   ANXIETY; DISEASE SEVERITY; RISK; SMOKING
AB Background Psoriasis is an inflammatory long-term condition involving comorbidities, unhealthy lifestyle and significant life impact. Patients' understanding of psoriasis is limited and support lacking. The Common-Sense Model of Self-Regulation of Health and Illness emphasizes the role of illness and treatment beliefs on coping and self-management. New 'Pso Well (R)' patient materials informed by the model, addressed psoriasis as a long-term condition, medication management and lifestyle behaviours.
   Objectives To investigate whether Pso Well (R) materials (i) broaden understanding of psoriasis without increasing anxiety; (ii) are acceptable; and (iii) comprise features that appear to effect change.
   Methods The Revised Illness Perceptions Questionnaire (IPQ-R modified) and the Hospital Anxiety and Depression Scale (HADS) were administered in patients before and after intervention. Numerical rating scales assessed perceptions of change in understanding and anxiety resulting from engagement with the materials. Qualitative interviews explored acceptability and perceived 'active ingredients'.
   Results Fifty-five patients completed pre- and postintervention questionnaires (56% female; median age 59years). Postintervention, a large effect size was indicated in two IPQ-R domains - illness coherence [t(55)= -3.48, P=0.001 (two-tailed), eta(2)=0.19] and personal control [t(55)=-2.98, P=0.004 (two-tailed), eta(2)=0.14] - and a medium effect in one, treatment control [t(55)= -2.08, P=0.042 (two-tailed), eta(2)=0.08]. HADS scores did not change. For numerical rating scales, 80% of participants reported increased understanding of psoriasis and none reported increased anxiety. Interviews with 19 patients indicated the materials were acceptable and usable. Factors reported to broaden understanding and promote engagement with self-management included linking of related disease aspects, personally relevant content and high-quality design.
   Conclusions High-quality, theory-based psoriasis materials are acceptable to patients and can improve understanding and sense of control without increasing anxiety.
C1 [Nelson, P. A.; Kane, K.; Pearce, C. J.; Bundy, C.; Chisholm, A.; Thorneloe, R.; Young, H.; Griffiths, C. E. M.] Univ Manchester, Div Musculoskeletal & Dermatol Res, Dermatol Ctr, Stopford Bldg,Oxford Rd, Manchester M13 9PT, Lancs, England.
   [Nelson, P. A.; Kane, K.; Pearce, C. J.; Bundy, C.; Chisholm, A.; Thorneloe, R.; Young, H.; Griffiths, C. E. M.; Cordingley, L.] Manchester Acad Hlth Sci Ctr, Manchester, Lancs, England.
   [Pearce, C. J.; Bundy, C.; Chisholm, A.; Thorneloe, R.; Cordingley, L.] Univ Manchester, Manchester Ctr Hlth Psychol, Manchester, Lancs, England.
   [Hilton, R.] Bridgewater Community Healthcare Trust, Wigan, England.
   [Young, H.; Griffiths, C. E. M.] Salford Royal NHS Fdn Trust, Manchester, England.
   [Cordingley, L.] Univ Manchester, Div Musculoskeletal & Dermatol Res, Manchester, Lancs, England.
C3 University of Manchester; University of Manchester; University of
   Manchester; Salford Royal NHS Foundation Trust; University of Manchester
RP Nelson, PA (corresponding author), Univ Manchester, Div Musculoskeletal & Dermatol Res, Dermatol Ctr, Stopford Bldg,Oxford Rd, Manchester M13 9PT, Lancs, England.; Nelson, PA (corresponding author), Manchester Acad Hlth Sci Ctr, Manchester, Lancs, England.
EM pauline.nelson@manchester.ac.uk
RI Cordingley, Lis/A-8067-2015; Young, Helen/H-5247-2015; Pearce,
   Christina/B-4745-2017; Bundy, Christine/I-4286-2015
OI Cordingley, Lis/0000-0001-7675-240X; Young, Helen/0000-0003-1538-445X;
   Nelson, Pauline A/0000-0003-4162-4736; Thorneloe,
   Rachael/0000-0002-7522-221X; Pearce, Christina/0000-0002-7393-191X;
   Bundy, Christine/0000-0002-5981-3984
FU National Institute for Health Research (NIHR) [RP-PG-0608-10163];
   National Institutes of Health Research (NIHR) [RP-PG-0608-10163] Funding
   Source: National Institutes of Health Research (NIHR)
FX This article presents independent research funded by the National
   Institute for Health Research (NIHR) under its Programme Grants for
   Applied Research scheme (RP-PG-0608-10163). The views expressed are
   those of the authors and not necessarily those of the National Health
   Service, the NIHR or the Department of Health.
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NR 78
TC 23
Z9 23
U1 0
U2 10
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0007-0963
EI 1365-2133
J9 BRIT J DERMATOL
JI Br. J. Dermatol.
PD SEP
PY 2017
VL 177
IS 3
BP 758
EP 770
DI 10.1111/bjd.15574
PG 13
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Dermatology
GA FH9KM
UT WOS:000411529400054
PM 28403510
OA Green Published, Green Accepted, hybrid
DA 2025-06-11
ER

PT J
AU Gouin, JP
   Thayer, JF
   Deschênes, SS
   MacNeil, S
   Booij, L
AF Gouin, Jean-Philippe
   Thayer, Julian F.
   Deschenes, Sonya S.
   MacNeil, Sasha
   Booij, Linda
TI Implicit Affect, Heart Rate Variability, and the Metabolic Syndrome
SO PSYCHOSOMATIC MEDICINE
LA English
DT Article
DE implicit affect; heart rate variability; metabolic syndrome; HR = heart
   rate; HRV = heart rate variability; IPANAT = Implicit Positive and
   Negative Affect Test; METs = metabolic syndrome; NA = negative affect;
   PA = positive affect
ID LIPID-ACCUMULATION PRODUCT; RESPIRATORY SINUS ARRHYTHMIA; CARDIAC VAGAL
   CONTROL; ALL-CAUSE MORTALITY; DEPRESSIVE SYMPTOMS;
   CARDIOVASCULAR-DISEASE; GENERALIZED UNSAFETY; STRESS; ASSOCIATION;
   STARTLE
AB Objective
   Greater negative affect has been associated with an increased risk of the metabolic syndrome (METs). However, all studies to date have examined this association using explicit affect measures based on subjective ratings of emotional experiences. Prior studies suggest that implicit affect, representing the automatic, prereflective appraisal process involved in conscious emotional experiences, is associated with physiological stress responses independent of explicit affect. Furthermore, low resting heart rate variability (HRV) may increase the risk of stress-related diseases. The goals of this study were to evaluate the associations between implicit and explicit affect and METs and to assess whether these associations were amplified by lower HRV. Methods
   This secondary analysis of a larger study included 217 middle-aged women who completed measures of implicit affect, explicit affect, high-frequency HRV, and the different components of METs. Results
   There was a significant interaction between implicit negative affect and HRV predicting METs (odds ratio = 0.57, 95% confidence interval = 0.35-0.92), such that the combination of higher implicit affect and lower HRV was associated with a greater likelihood of METs. Similarly, there was a main effect of implicit negative affect as well as an interaction between implicit negative affect and HRV on the lipid accumulation product (b (standard error) = -0.06 (0.02), 95% confidence interval = -0.11 to -0.02), a combination of waist circumference and triglycerides. Conclusions
   Higher implicit negative affect in the context of lower HRV may be related to a greater risk of METs. The present findings highlight the relevance of including implicit affect measures in psychosomatic medicine research.
C1 [Gouin, Jean-Philippe; MacNeil, Sasha; Booij, Linda] Concordia Univ, Dept Psychol, 7141,Sherbrooke St West,PY170-14, Montreal, PQ H4B 1R6, Canada.
   [Thayer, Julian F.] Univ Calif Irvine, Dept Psychol Sci, Irvine, CA USA.
   [Deschenes, Sonya S.] Univ Coll Dublin, Sch Psychol, Dublin, Ireland.
C3 Concordia University - Canada; University of California System;
   University of California Irvine; University College Dublin
RP Gouin, JP (corresponding author), Concordia Univ, Dept Psychol, 7141,Sherbrooke St West,PY170-14, Montreal, PQ H4B 1R6, Canada.
EM jp.gouin@concordia.ca; jfthayer@gmail.com;
   sonya.deschenes@mail.mcgill.ca; sasha.macneil@gmail.com;
   linda.booij@concordia.ca
RI Thayer, Julian/AAA-1161-2020; Deschenes, Sonya/G-6341-2017
OI MacNeil, Sasha/0000-0002-1865-5713; Deschenes, Sonya/0000-0002-9258-0895
FU Canadian Institutes for Health Research; Canada Research Chair award
FX This study was funded by an operating grant from the Canadian Institutes
   for Health Research and a Canada Research Chair award to J.-P.G. None of
   the authors had conflicts of interest to declare.
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NR 78
TC 5
Z9 5
U1 2
U2 9
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0033-3174
EI 1534-7796
J9 PSYCHOSOM MED
JI Psychosom. Med.
PD JAN
PY 2021
VL 83
IS 1
BP 24
EP 32
DI 10.1097/PSY.0000000000000879
PG 9
WC Psychiatry; Psychology; Psychology, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry; Psychology
GA QE8SS
UT WOS:000616476000003
PM 33065585
DA 2025-06-11
ER

PT J
AU Dorkova, Z
   Petrasova, D
   Molcanyiova, A
   Popovnakova, M
   Tkacova, R
AF Dorkova, Zuzana
   Petrasova, Darina
   Molcanyiova, Angela
   Popovnakova, Marcela
   Tkacova, Ruzena
TI Effects of Continuous Positive Airway Pressure on Cardiovascular Risk
   Profile in Patients With Severe Obstructive Sleep Apnea and Metabolic
   Syndrome
SO CHEST
LA English
DT Article
DE compliance; continuous positive airway pressure; insulin resistance;
   metabolic syndrome; risk factors; sleep apnea
ID C-REACTIVE PROTEIN; INSULIN SENSITIVITY; CPAP TREATMENT; GLUCOSE;
   ASSOCIATION; RESISTANCE; HYPOPNEA; THERAPY; MEN
AB Background: The increased risk of atherosclerotic morbidity and mortality in patients with obstructive sleep apnea (OSA) has been linked to arterial hypertension, insulin resistance, systemic inflammation, and oxidative stress. We aimed to determine the effects of 8 weeks of therapy with continuous positive airway pressure (CPAP) on glucose and lipid profile, systemic inflammation, oxidative stress, and global cardiovascular disease (CVD) risk in patients with severe OSA and metabolic syndrome.
   Methods: In 32 patients, serum cholesterol, triglycerides, high-density lipoprotein cholesterol, fibrinogen, apolipoprotein A-I, apolipoprotein B (ApoB), high-sensitivity C-reactive protein, interleukin-6, tumor necrosis factor (TNF)-alpha, leptin, malondialdehyde (MDA), and crythrocytic glutathione peroxidase (GPx) activity were measured at baseline and after 8 weeks of CPAP. The insulin resistance index (homeostasis model assessment [HOMA-IR]) was based on the homeostasis model assessment method, the CVD risk was calculated using the multivariable risk factor algorithm.
   Results: In patients who used CPAP for >= 4 h/night (n = 16), CPAP therapy reduced systolic BP and diastolic BP (p = 0.001 and p = 0.006, respectively), total cholesterol (p = 0.002), ApoB (p = 0.009), HOMA-IR (p = 0.031), MDA (p = 0.004), and TNF-alpha (p = 0.037), and increased erythrocytic GPx activity (p = 0.015), in association with reductions in the global CVD risk (from 18.8 +/- 9.8 to 13.9 +/- 9.7%, p = 0.001). No significant changes were seen in patients who used CPAP for < 4 h/night. Mask leak was the strongest predictor of compliance with CPAP therapy.
   Conclusions: In Patients with severe OSA and metabolic syndrome, good compliance to CPAP may improve insulin sensitivity, reduce systemic inflammation and oxidative stress, and reduce the global CVD risk.
   Trial registration: Clinicaltrials.gov Identifier: NCT00635674. (CHEST 2008; 134:686-692)
C1 [Dorkova, Zuzana; Tkacova, Ruzena] Safarik Univ, Fac Med, Dept Resp Med, Kosice 04190, Slovakia.
   [Dorkova, Zuzana; Tkacova, Ruzena] L Pasteur Teaching Hosp, Kosice, Slovakia.
   [Petrasova, Darina] Fac Med, Inst Expt Med, Kosice, Slovakia.
   [Molcanyiova, Angela; Popovnakova, Marcela] LABMED, Dept Biochem, Kosice, Slovakia.
C3 University of Pavol Jozef Safarik Kosice
RP Tkacova, R (corresponding author), Safarik Univ, Fac Med, Dept Resp Med, Rastislavova 43, Kosice 04190, Slovakia.
EM rtkacova@medic.upjs.sk
OI Petrasova, Darina/0000-0002-2425-1547
CR [Anonymous], 2005, IDF CONS WORLDW DEF
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NR 36
TC 233
Z9 248
U1 0
U2 17
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0012-3692
EI 1931-3543
J9 CHEST
JI Chest
PD OCT
PY 2008
VL 134
IS 4
BP 686
EP 692
DI 10.1378/chest.08-0556
PG 7
WC Critical Care Medicine; Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Respiratory System
GA 360ZP
UT WOS:000260097600007
PM 18625666
DA 2025-06-11
ER

PT J
AU Kon, K
   Ikejima, K
   Okumura, K
   Arai, K
   Aoyama, T
   Watanabe, S
AF Kon, Kazuyoshi
   Ikejima, Kenichi
   Okumura, Kyoko
   Arai, Kumiko
   Aoyama, Tomonori
   Watanabe, Sumio
TI Diabetic KK-A<SUP>y</SUP> mice are highly susceptible to oxidative
   hepatocellular damage induced by acetaminophen
SO AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
LA English
DT Article
DE drug-induced liver injury; metabolic syndrome; steatohepatitis;
   oxidative stress; hepatotoxicity
ID NONALCOHOLIC FATTY LIVER; MITOCHONDRIAL PERMEABILITY TRANSITION; INJURY;
   STEATOHEPATITIS; PROTECTION; OBESE; BUTYLHYDROPEROXIDE; HEPATOCYTES;
   MECHANISMS; FIBROSIS
AB Kon K, Ikejima K, Okumura K, Arai K, Aoyama T, Watanabe S. Diabetic KK-A(y) mice are highly susceptible to oxidative hepatocellular damage induced by acetaminophen. Am J Physiol Gastrointest Liver Physiol 299: G329-G337, 2010. First published June 10, 2010; doi:10.1152/ajpgi.00361.2009.-Despite pathophysiological similarities to alcoholic liver disease, susceptibility to acetaminophen hepatotoxicity in metabolic syndrome-related nonalcoholic steatohepatitis (NASH) has not been well elucidated. In this study, therefore, we investigated acetaminophen-induced liver injury in KK-A(y) mice, an animal model of metabolic syndrome. Twelve-week-old male KK-A(y) and C57Bl/6 mice were injected intraperitoneally with 300 or 600 mg/kg acetaminophen, and euthanized 6 h later. Liver histology was assessed, and hepatic expression of 4-hydroxy-2-non-enal was detected by immunohistochemistry. Levels of reduced glutathione were determined spectrophotometrically. Phosphorylation of c-Jun NH2-terminal kinase (JNK) was analyzed by Western blotting. Hepatocytes were isolated from both strains by collagenase perfusion, and cell death and oxidative stress were measured fluorometrically by use of propidium iodide and 5-(and-6)-chloromethyl-2'7'-dichloro-dihydrofluorescein diacetate acetyl ester, respectively. Acetaminophen induced more severe necrosis and apoptosis of hepatocytes in KK-A(y) mice than in C57Bl/6 mice and significantly increased serum alanine aminotransferase levels in KK-A(y) mice. Acetaminophen induction of 4-hydroxy-2-nonenal in the liver was potentiated, whereas the levels of reduced glutathione in liver were lower in KK-Ay mice. Acetaminophen-induced phosphorylation of JNK in the liver was also enhanced in KK-Ay mice. Exposure to 20 mu M tert-butyl hydroperoxide did not kill hepatocytes isolated from C57Bl/6 mice but induced cell death and higher oxidative stress in hepatocytes from KK-A(y) mice. These results demonstrated that acetaminophen toxicity is increased in diabetic KK-Ay mice mainly due to enhanced oxidative stress in hepatocytes, suggesting that metabolic syndrome-related steatohepatitis is an exacerbating factor for acetaminophen-induced liver injury.
C1 [Kon, Kazuyoshi; Ikejima, Kenichi; Okumura, Kyoko; Arai, Kumiko; Aoyama, Tomonori; Watanabe, Sumio] Juntendo Univ, Sch Med, Dept Gastroenterol, Tokyo 113, Japan.
   [Ikejima, Kenichi; Aoyama, Tomonori; Watanabe, Sumio] Juntendo Univ, Grad Sch Med, Sportol Ctr, Tokyo, Japan.
C3 Juntendo University; Juntendo University
RP Ikejima, K (corresponding author), 2-1-1 Hongo,Bunkyo Ku, Tokyo 1138421, Japan.
EM ikejima@juntendo.ac.jp
RI Kon, Kazuyoshi/AAV-7832-2020
OI Kon, Kazuyoshi/0000-0002-1127-2218
FU Ministry of Education, Culture, Sports, Science and Technology of Japan;
   Ministry of Health, Labour and Welfare of Japan; Liver Forum in Kyoto;
   Takeda Science Foundation; Research Conference on Alcohol and Health; 
   [18790474];  [20790508];  [16590633];  [19590791];  [21590859]; 
   [18390213];  [21390234]
FX This work was supported in part by Grant-in-Aid (Nos. 18790474 and
   20790508 to K. Kon; 16590633, 19590791, and 21590859 to K. Ikejima; and
   18390213 and 21390234 to S. Watanabe); and High Technology Research
   Center Grant from the Ministry of Education, Culture, Sports, Science
   and Technology of Japan, Health and Labour Science Research Grant from
   the Ministry of Health, Labour and Welfare of Japan (to S. Watanabe);
   and grants from Liver Forum in Kyoto (cosponsored by Viral Hepatitis
   Research Foundation in Japan and Dainippon Sumitomo Pharma, to K.
   Ikejima), Takeda Science Foundation (to K. Ikejima), and Research
   Conference on Alcohol and Health (sponsored by Suntory, to K. Ikejima).
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NR 43
TC 30
Z9 32
U1 0
U2 1
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0193-1857
EI 1522-1547
J9 AM J PHYSIOL-GASTR L
JI Am. J. Physiol.-Gastroint. Liver Physiol.
PD AUG
PY 2010
VL 299
IS 2
BP G329
EP G337
DI 10.1152/ajpgi.00361.2009
PG 9
WC Gastroenterology & Hepatology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Physiology
GA 633EU
UT WOS:000280483200006
PM 20539006
DA 2025-06-11
ER

PT J
AU Merce, AP
   Ionica, LN
   Bîna, AM
   Popescu, S
   Lighezan, R
   Petrescu, L
   Borza, C
   Sturza, A
   Muntean, DM
   Cretu, OM
AF Merce, Adrian P.
   Ionica, Loredana N.
   Bina, Anca M.
   Popescu, Simona
   Lighezan, Rodica
   Petrescu, Lucian
   Borza, Claudia
   Sturza, Adrian
   Muntean, Danina M.
   Cretu, Octavian M.
TI Monoamine oxidase is a source of cardiac oxidative stress in obese rats:
   the beneficial role of metformin
SO MOLECULAR AND CELLULAR BIOCHEMISTRY
LA English
DT Article
DE Diet-induced obesity; Rat model; Monoamine oxidase; Oxidative stress;
   Metformin; MAO inhibitors
ID DYSFUNCTION; INHIBITION; APOPTOSIS; FAILURE; CARDIOMYOCYTES;
   MITOCHONDRIAL; ACTIVATION; DEPRESSION; SEROTONIN
AB Diet-induced metabolic diseases, such as obesity, metabolic syndrome, and type 2 diabetes (T2DM) are the global threatening epidemics that share cardiovascular oxidative stress as common denominator. Monoamine oxidase (MAO) has recently emerged as a constant source of reactive oxygen species (ROS) in DM. Metformin, the first-line drug in T2DM, elicits cardiovascular protection via pleiotropic effects. The present study was aimed to assess the contribution of MAO to the early cardiac oxidative stress in a rat model of high-calorie junk food (HCJF) diet-induced obesity and prediabetes and whether metformin can alleviate it. After 6 months of HCJF, rats developed obesity and hyperglycemia. Hearts were isolated and used for the evaluation of MAO expression and ROS production. Experiments were performed in the presence vs absence of metformin (10 mu M) and MAO-A and B inhibitors (clorgyline and selegiline, 10 mu M), respectively. Both MAO isoforms were overexpressed and led to increased ROS generation in cardiac samples harvested from the obese animals. Acute treatment with metformin and MAO inhibitors was able to mitigate oxidative stress. More important, metformin downregulated MAO expression in the diseased samples. In conclusion, MAO contributes to oxidative stress in experimental obesity and can be targeted with metformin.
C1 [Merce, Adrian P.; Ionica, Loredana N.; Bina, Anca M.; Borza, Claudia; Sturza, Adrian; Muntean, Danina M.] Victor Babes Univ Med & Pharm, Dept Funct Sci Pathophysiol, Eftimie Murgu Sq 2, Timisoara 300041, Romania.
   [Merce, Adrian P.; Ionica, Loredana N.; Bina, Anca M.; Borza, Claudia; Sturza, Adrian; Muntean, Danina M.] Victor Babes Univ Med & Pharm, Ctr Translat Res & Syst Med, EftimieMurgu Sq 2, Timisoara 300041, Romania.
   [Popescu, Simona] Victor Babes Univ Med & Pharm, Dept Internal Med Diabet Nutr Metab Dis 7, Eftimie Murgu Sq 2, Timisoara 300041, Romania.
   [Lighezan, Rodica] Victor Babes Univ Med & Pharm, Dept Infect Dis Parasitol, Eftimie Murgu Sq 2, Timisoara 300041, Romania.
   [Petrescu, Lucian] Victor Babes Univ Med & Pharm, Dept Cardiol Cardiol 2, Eftimie Murgu Sq 2, Timisoara 300041, Romania.
   [Cretu, Octavian M.] Victor Babes Univ Med & Pharm, Dept Surg Surg Semiot, Eftimie Murgu Sq 2, Timisoara 300041, Romania.
   [Cretu, Octavian M.] Victor Babes Univ Med & Pharm Timisoara, Ctr Hepatobiliary & Pancreat Surg, Eftimie Murgu Sq 2, Timisoara 300041, Romania.
   [Sturza, Adrian; Muntean, Danina M.] Victor Babes Univ Med & Pharm Timisoara, Dept Funct Sci Pathophysiol 3, Ctr Translat Res & Syst Med, Eftimie Murgu Sq 2, Timisoara 300041, Romania.
C3 Victor Babes University of Medicine & Pharmacy, Timisoara; Victor Babes
   University of Medicine & Pharmacy, Timisoara; Victor Babes University of
   Medicine & Pharmacy, Timisoara; Victor Babes University of Medicine &
   Pharmacy, Timisoara; Victor Babes University of Medicine & Pharmacy,
   Timisoara; Victor Babes University of Medicine & Pharmacy, Timisoara;
   Victor Babes University of Medicine & Pharmacy, Timisoara; Victor Babes
   University of Medicine & Pharmacy, Timisoara
RP Sturza, A; Muntean, DM (corresponding author), Victor Babes Univ Med & Pharm, Dept Funct Sci Pathophysiol, Eftimie Murgu Sq 2, Timisoara 300041, Romania.; Sturza, A; Muntean, DM (corresponding author), Victor Babes Univ Med & Pharm, Ctr Translat Res & Syst Med, EftimieMurgu Sq 2, Timisoara 300041, Romania.; Sturza, A; Muntean, DM (corresponding author), Victor Babes Univ Med & Pharm Timisoara, Dept Funct Sci Pathophysiol 3, Ctr Translat Res & Syst Med, Eftimie Murgu Sq 2, Timisoara 300041, Romania.
EM sturza.adrian@umft.ro; daninamuntean@umft.ro
RI Ionica, Loredana/KQU-0648-2024; Popescu, Simona/LVS-4786-2024; Sturza,
   Adrian/AAL-8869-2020; Muntean, Danina Mirela/G-3138-2016; Cretu,
   Octavian/LWH-8125-2024; Bina, Anca/HGU-5256-2022; claudia,
   Borza/ABH-5975-2020
OI Ionica, Loredana Nicoleta/0009-0004-9042-8349; Popescu,
   Simona/0000-0001-8167-9657; STURZA, ADRIAN/0000-0003-2496-5416
FU "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania
   [6POSTDOC/1871/12.02.2020]
FX Funding was provided by "Victor Babes" University of Medicine and
   Pharmacy, Timisoara, Romania (6POSTDOC/1871/12.02.2020).
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NR 50
TC 13
Z9 13
U1 6
U2 18
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0300-8177
EI 1573-4919
J9 MOL CELL BIOCHEM
JI Mol. Cell. Biochem.
PD JAN
PY 2023
VL 478
IS 1
BP 59
EP 67
DI 10.1007/s11010-022-04490-5
EA JUN 2022
PG 9
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA 7W5KD
UT WOS:000813781100001
PM 35723772
DA 2025-06-11
ER

PT J
AU Shariat, A
   Farhangi, MA
   Zeinahan, R
AF Shariat, Atefeh
   Farhangi, Mandieh Abbasalizad
   Zeinahan, Reihaneh
TI Association between serum levels of vascular endothelial growth factor,
   macrophage inhibitory cytokine and markers of oxidative stress, with the
   metabolic syndrome and its components in obese individuals
SO NUTRITION CLINIQUE ET METABOLISME
LA English
DT Article
DE Metabolic Syndrome; VEGF; MIC-1; Oxidative stress
ID CARDIOVASCULAR RISK; INSULIN-RESISTANCE; BIOMARKERS; MORTALITY; PROFILE;
   MEMBER; MIC-1
AB Aim. - Metabolic syndrome (MetS) is a clinical disorder with widespread prevalence. In the current study, we aimed to investigate the serum values of macrophage inhibitory cytokine (MIC)-1, vascular endothelial growth factor (VEGF) and markers of oxidative stress among patients with metabolic syndrome.
   Material and methods. - Twenty obese patients with MetS and 20 obese apparently healthy controls were participated in the current case-control study. The participants' body mass index (BMI), waist circumference (WC), systolic and diastolic blood pressure (SBP and DBP) were measured. Serum levels of total cholesterol (TC), triglyceride (TG), low and high density lipoprotein cholesterol (LDL-c and HDL-c), vascular endothelial growth factor (VEGF), MIC-1 (macrophage inhibitory cytokine 1), superoxide dismutase (SOD) and glutathione peroxidase (GPX) were also determined by commercial ELIZA kits.
   Results. - Participants in MetS group had higher levels of WC, DBP and higher serum concentrations of TG and TC compared with control group (P < 0.05). Serum VEGF and MIC-1 levels were significantly higher in patients with MetS compared with control subjects (P < 0.05). There was a significant and positive association between serum levels of VEGF and LDL (P = 0.027; beta = 0.453) in all of the study participants. Moreover, an inverse association between serum GPX with DBP and between SOD with WC were also seen (P < 0.05).
   Conclusion. - The higher serum values of MIC-1 and VEGF in patients with MetS and the negative association of VEGF with serum LDL concentrations opened a new window about the possible pathologic role of these factors in the etiology or pathophysiology of MetS. Further studies are warranted for solidification of achieved results. (C) 2018 Published by Elsevier Masson SAS on behalf of Association pour le developpement de la recherche en nutrition (ADREN).
C1 [Shariat, Atefeh] Tabriz Univ Med Sci, Fac Nutr, Nutr Res Ctr, Dept Nutr Community, Tabriz, Iran.
   [Farhangi, Mandieh Abbasalizad] Tabriz Univ Med Sci, Drug Appl Res Ctr, Dept Community Nutr, Tabriz, Iran.
   [Zeinahan, Reihaneh] Tabriz Univ Med Sci, Student Res Comm, Tabriz, Iran.
C3 Tabriz University of Medical Science; Tabriz University of Medical
   Science; Tabriz University of Medical Science
RP Farhangi, MA (corresponding author), Tabriz Univ Med Sci, Attar Neyshabouri St, Tabriz 411675, Iran.
EM abbasalizad_m@yahoo.com
RI Farhangi, Mahdieh/AAC-6758-2019
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NR 35
TC 3
Z9 3
U1 0
U2 1
PU MASSON EDITEUR
PI MOULINEAUX CEDEX 9
PA 21 STREET CAMILLE DESMOULINS, ISSY, 92789 MOULINEAUX CEDEX 9, FRANCE
SN 0985-0562
EI 1768-3092
J9 NUTR CLIN METAB
JI Nutr. Clin. Metab.
PD MAY
PY 2018
VL 32
IS 2
BP 95
EP 101
DI 10.1016/j.nupar.2018.02.003
PG 7
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA GG7UR
UT WOS:000432903900004
DA 2025-06-11
ER

PT J
AU Bailey, DP
AF Bailey, Daniel P.
TI Sedentary behaviour in the workplace: prevalence, health implications
   and interventions
SO BRITISH MEDICAL BULLETIN
LA English
DT Review
DE sitting; office workers; occupational health; sit-stand desks; sedentary
   behaviour; physical activity
ID RECREATIONAL PHYSICAL-ACTIVITY; RANDOMIZED CONTROLLED-TRIAL; SITTING
   TIME; POSTMENOPAUSAL WOMEN; CARDIOMETABOLIC RISK; MENTAL-HEALTH;
   ASSOCIATIONS; BREAKING; WALKING; ADULTS
AB Introduction: This paper reviews the prevalence and health risks of excess sedentary behaviour in office workers, and the effectiveness of sedentary workplace interventions in a manner accessible to practitioners.
   Sources of data: A narrative review of empirical studies obtained from PubMed and Web of Science.
   Areas of agreement: Office workers are highly sedentary, increasing their risk of health problems. Interventions using individual, organisational and environmental level strategies can be effective for reducing workplace sitting.
   Areas of controversy: The effects of sedentary workplace interventions on health are inconsistent. This may be due to a lack of randomized controlled trials powered to detect changes in health outcomes.
   Growing points: Multicomponent interventions that use a combination of the strategies above may be the most effective for reducing sitting.
   Areas timely for developing research: Determining the long-term health and cost-effectiveness of sedentary workplace interventions is a priority to encourage employer buy-in for their implementation.
C1 [Bailey, Daniel P.] Brunel Univ London, Sedentary Behav Hlth & Dis Res Grp, Kingston Lane, Uxbridge UB8 3PH, Middx, England.
   [Bailey, Daniel P.] Brunel Univ London, Dept Life Sci, Div Sport Hlth & Exercise Sci, Kingston Lane, Uxbridge UB8 3PH, Middx, England.
C3 Brunel University; Brunel University
RP Bailey, DP (corresponding author), Brunel Univ London, Sedentary Behav Hlth & Dis Res Grp, Kingston Lane, Uxbridge UB8 3PH, Middx, England.; Bailey, DP (corresponding author), Brunel Univ London, Dept Life Sci, Div Sport Hlth & Exercise Sci, Kingston Lane, Uxbridge UB8 3PH, Middx, England.
EM daniel.bailey@brunel.ac.uk
RI Bailey, Daniel/HDL-7697-2022
OI Bailey, Daniel/0000-0003-3772-630X
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NR 50
TC 32
Z9 32
U1 3
U2 77
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0007-1420
EI 1471-8391
J9 BRIT MED BULL
JI Br. Med. Bull.
PD MAR
PY 2021
VL 137
IS 1
BP 42
EP 50
DI 10.1093/bmb/ldaa039
EA MAR 2021
PG 9
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA RZ9PE
UT WOS:000648930200004
PM 33710270
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Musa, KH
   Hamad, EM
   Elnour, AAM
AF Musa, Khalid Hamid
   Hamad, Essam M.
   Elnour, Ahmed A. M.
TI Camel Milk and Oxidative stress: Therapeutic potential against metabolic
   syndrome diseases
SO JOURNAL OF AGRICULTURE AND FOOD RESEARCH
LA English
DT Article
DE Camel milk; Oxidative stress; Antioxidant; Reactive oxygen species;
   Anti-inflammation; Immunomodulatory
ID FREE-RADICALS; FATTY-ACID; DROMEDARIUS MILK; ANTIOXIDANT; VITAMIN;
   PROTEINS; QUALITY; CELLS; MICE; COW
AB Background: Camel milk (CM) has emerged as a potential therapeutic agent against oxidative stress (OS)-related disorders, particularly metabolic syndrome. CM contains bioactive compounds such as lactoferrin, alpha-lactalbumin, and Vitamin C, which contribute to its antioxidant properties. Objective: This review examines the antioxidant properties of CM and its bioactive components in combating OS and managing metabolic syndrome. Methods: A comprehensive literature review was conducted focusing on studies that explored the antioxidant properties of CM and its impact on OS and metabolic syndrome. Results: The findings indicated CM possesses significant antioxidant properties, mainly attributed to its bioactive compounds, which can inhibit the production of various reactive oxygen species (ROS), thereby reducing OS. Evidence suggests that CM enhances the body's antioxidative defense, improves insulin sensitivity, and supports liver and kidney function. CM's multifaceted approach shows promise as a therapeutic strategy for metabolic disorders related to OS. Conclusion: Considering its robust antioxidant qualities and capacity to regulate immune responses while enhancing metabolic health indicators, CM may be a valuable asset in the natural therapeutic repertoire to counter metabolic syndromes. Further clinical trials and research are essential to fully comprehend the therapeutic potential of CM, including dosage, long-term implications, and integration within extensive treatment schemes for metabolic syndromes and associated disorders. Recommendation: The use of CM to reduce OS requires further clinical studies to confirm its benefits and identify key compounds. Standardization of production and processing is essential for quality and safety, and research into potential risks and side effects is needed, especially for those with specific health conditions. Enhancing the accessibility, affordability, and sustainability of production methods is critical. Fortifying camel's milk with vitamins and minerals can improve its nutritional value.
C1 [Musa, Khalid Hamid; Hamad, Essam M.] Qassim Univ, Coll Agr & Food, Dept Food Sci & Human Nutr, Buraydah 51452, Saudi Arabia.
   [Elnour, Ahmed A. M.] Univ Malaysia Pahang Al Sultan Abdullah UMPSA, Fac Chem & Proc Engn Technol, Pekan, Pahang, Malaysia.
   [Elnour, Ahmed A. M.] Univ Malaysia Pahang Al Sultan Abdullah UMPSA, Ctr Excellence Adv Res Fluid Flow CARIFF, Pekan, Pahang, Malaysia.
C3 Qassim University
RP Elnour, AAM (corresponding author), Univ Malaysia Pahang Al Sultan Abdullah UMPSA, Fac Chem & Proc Engn Technol, Pekan, Pahang, Malaysia.
EM k.musa@qu.edu.sa; e.hamad@qu.edu.sa; adamhassan@umpsa.edu.my
RI Hamad, Essam/HIK-0482-2022; Elnour; PhD, Ahmed/J-6257-2015; Musa, Khalid
   Hamid/C-8014-2011
OI Musa, Khalid Hamid/0000-0001-5938-7228
FU Deanship of Graduate Studies and Scientific Research at Qassim
   University [QU-APC-2025]
FX The Researchers would like to thank the Deanship of Graduate Studies and
   Scientific Research at Qassim University for financial sup-port
   (QU-APC-2025) .
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NR 133
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2666-1543
J9 J AGR FOOD RES
JI J. Agric. Food Res.
PD MAR
PY 2025
VL 19
AR 101682
DI 10.1016/j.jafr.2025.101682
EA FEB 2025
PG 13
WC Agriculture, Multidisciplinary; Food Science & Technology
WE Emerging Sources Citation Index (ESCI)
SC Agriculture; Food Science & Technology
GA Y3D9U
UT WOS:001430985400001
OA gold
DA 2025-06-11
ER

PT J
AU Niewiadomska, J
   Kasztura, M
   Janus, I
   Chelmecka, E
   Stygar, DM
   Frydrychowski, P
   Wojdylo, A
   Noszczyk-Nowak, A
AF Niewiadomska, Joanna
   Kasztura, Monika
   Janus, Izabela
   Chelmecka, Elzbieta
   Stygar, Dominika Marta
   Frydrychowski, Piotr
   Wojdylo, Aneta
   Noszczyk-Nowak, Agnieszka
TI Punica granatum L. Extract Shows Cardioprotective Effects
   Measured by Oxidative Stress Markers and Biomarkers of Heart Failure in
   an Animal Model of Metabolic Syndrome
SO ANTIOXIDANTS
LA English
DT Article
DE Punica granatum L; peels; cardioprotection; oxidative stress; metabolic
   syndrome
ID ELLAGIC ACID; POMEGRANATE PEEL; MYOCARDIAL-INFARCTION; CORONARY;
   ATHEROTHROMBOSIS; HYPERTENSION; INFLAMMATION; POLYPHENOLS; DYSFUNCTION;
   GALECTIN-3
AB Metabolic syndrome (MetS) significantly increases the risk of cardiovascular diseases (CVD), a leading cause of death globally. The presented study investigated the cardioprotective role of dietary polyphenols found in pomegranate peels in an animal model of metabolic syndrome. Zucker diabetic fatty rats (ZDF, MetS rats, fa/fa) were supplemented with polyphenol-rich pomegranate peel extract (EPP) at two dosages: 100 mg/kg BW and 200 mg/kg BW. The extract was administered for 8 weeks. The effect of ethanolic peel extract on the concentration of oxidative stress markers (CAT, SOD, MnSOD, GR, GST, GPx, TOS, SH, and MDA), biomarkers of heart failure (cTnI, GAL-3), and alternations in tissue architecture was assessed. The results showed a significant increase in SH concentration mediated via EPP supplementation (p < 0.001). Treatment with a 100 mg/kg BW dosage reduced the TOS level more efficiently than the higher dose. Interestingly, the CAT and GST activities were relevantly higher in the MetS 100 group (p < 0.001) compared to the MetS control. The rats administered EPP at a dose of 200 mg/kg BW did not follow a similar trend. No differences in the GR (p = 0.063), SOD (p = 0.455), MnSOD (p = 0.155), and MDA (p = 0.790) concentration were observed after exposure to the pomegranate peel extract. The administration of EPP did not influence the cTnI and GAL-3 levels. Histology analysis of the heart and aorta sections revealed no toxic changes in phenolic-treated rats. The findings of this study prove that the extract from pomegranate peels possesses free radical scavenging properties in the myocardium. The effect on alleviating ventricular remodeling and cardiomyocyte necrosis was not confirmed and requires further investigation.
C1 [Niewiadomska, Joanna; Frydrychowski, Piotr; Noszczyk-Nowak, Agnieszka] Wroclaw Univ Environm & Life Sci, Fac Vet Med, Dept Internal & Dis, Clin Horses Dogs & Cats, PL-50375 Wroclaw, Poland.
   [Kasztura, Monika] Wroclaw Univ Environm & Life Sci, Dept Food Hyg & Consumer Hlth Protect, PL-50375 Wroclaw, Poland.
   [Janus, Izabela] Wroclaw Univ Environm & Life Sci, Fac Vet Med, Dept Pathol, Div Pathomorphol & Vet Forens, CK Norwida 31, PL-50375 Wroclaw, Poland.
   [Chelmecka, Elzbieta] Sosnowiec Med Univ Silesia, Dept Stat, Dept Instrumental Anal, Fac Pharmaceut Sci, PL-40751 Katowice, Poland.
   [Stygar, Dominika Marta] Med Univ Silesia, Fac Med Sci Zabrze, Dept Physiol, PL-40751 Katowice, Poland.
   [Wojdylo, Aneta] Wroclaw Univ Environm & Life Sci, Dept Fruit Vegetable & Nutraceut Plant Technol, PL-51630 Wroclaw, Poland.
C3 Wroclaw University of Environmental & Life Sciences; Wroclaw University
   of Environmental & Life Sciences; Wroclaw University of Environmental &
   Life Sciences; Medical University of Silesia; Medical University of
   Silesia; Wroclaw University of Environmental & Life Sciences
RP Niewiadomska, J; Noszczyk-Nowak, A (corresponding author), Wroclaw Univ Environm & Life Sci, Fac Vet Med, Dept Internal & Dis, Clin Horses Dogs & Cats, PL-50375 Wroclaw, Poland.
EM joanna.niewiadomska@upwr.edu.pl; monika.kasztura@upwr.edu.pl;
   izabela.janus@upwr.edu.pl; echelmecka@sum.edu.pl; dstygar@sum.edu.pl;
   piotr.frydrychowski@upwr.edu.pl; aneta.wojdylo@upwr.edu.pl;
   agnieszka.noszczyk-nowak@upwr.edu.pl
RI Wojdyło, Aneta/B-3639-2017; Noszczyk-Nowak, Agnieszka/AAF-8041-2020;
   Stygar, Dominika/ABG-6437-2021; Noszczyk-Nowak, Agnieszka/G-9438-2017;
   Frydrychowski, Piotr/W-1578-2018; Stygar, Dominika/T-4634-2018;
   Chelmecka, Elzbieta/O-5223-2015; Janus-Ziolkowska, Izabela/GQH-6690-2022
OI Noszczyk-Nowak, Agnieszka/0000-0001-7899-3936; Niewiadomska,
   Joanna/0000-0001-7102-0779; Frydrychowski, Piotr/0000-0001-6688-3051;
   Stygar, Dominika/0000-0001-8509-7507; Wojdylo,
   Aneta/0000-0002-0067-0691; Chelmecka, Elzbieta/0000-0002-0111-438X;
   Janus-Ziolkowska, Izabela/0000-0001-5166-856X
FU project "International multicentric platform as a key element for the
   effective scientific research"; Polish National Agency for Academic
   Exchange [PPI/APM/2019/1/00044/U/00001]
FX The work was supported by the project "International multicentric
   platform as a key element for the effective scientific research",
   financed by the Polish National Agency for Academic Exchange (grant no.
   PPI/APM/2019/1/00044/U/00001).
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NR 76
TC 6
Z9 6
U1 2
U2 8
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD JUN
PY 2023
VL 12
IS 6
AR 1152
DI 10.3390/antiox12061152
PG 20
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA K1CW3
UT WOS:001013903200001
PM 37371882
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Ajiboye, TO
   Hussaini, AA
   Nafiu, BY
   Ibitoye, OB
AF Ajiboye, T. O.
   Hussaini, A. A.
   Nafiu, B. Y.
   Ibitoye, O. B.
TI Aqueous seed extract of Hunteria umbellata (K. Schum.) Hallier f.
   (Apocynaceae) palliates hyperglycemia, insulin resistance, dyslipidemia,
   inflammation and oxidative stress in high-fructose diet-induced
   metabolic syndrome in rats
SO JOURNAL OF ETHNOPHARMACOLOGY
LA English
DT Article
DE Hunteria umbellata; Insulin resistance; High-fructose diet;
   Dyslipidemia; Metabolic syndrome; Inflammation; Oxidative stress
ID HEPATIC STEATOSIS; ADIPOSE-TISSUE; URSOLIC ACID; ADIPONECTIN;
   ANTIOXIDANT; GLUCOSE; LEAVES; LIVER; FAT; SUPPLEMENTATION
AB Ethnopharmacological relevance: Hunteria umbellata is used in the management and treatment of diabetes and obesity in Nigeria. This study evaluates the effect of aqueous seed extract of Hunteria umbellata on insulin resistance, dyslipidemia, inflammation and oxidative stress in high-fructose diet-induced metabolic syndrome
   Materials and methods: Rats were randomized into seven groups (A-G). Control (group A) and group C rats received control diet for nine weeks while rats in groups B, D - G were placed on high-fructose diet for 9 weeks. In addition to the diets, groups C-F rats orally received 400, 100, 200 and 400 mg/kg body weight aqueous seed extract of Hunteria umbellata for 3 weeks starting from 6th - 9th week.
   Results: High-fructose diet (when compared to control rats) mediated a significant (p < 0.05) increase in body weight, body mass index and abdominal circumference. Similarly, levels of blood glucose, insulin, leptin, adiponectin and insulin resistance were increased. It also caused a significant increase in the levels of cholesterol, triglycerides, low-density lipoprotein cholesterol, very low-density lipoprotein cholesterol, atherogenic index, cardiac index and coronary artery index while high-density lipoprotein cholesterol was decreased significantly. Levels of proinflammatory factor, tumour necrosis factor-a, interleukin-6 and 8 were also increased by the high fructose diet. Moreover, it mediated decrease in activities of superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, glucose 6-phosphate dehydrogenase and level of glutathione reduced. Conversely, levels of malondialdehyde, conjugated dienes, lipid hydroperoxides, protein carbonyl and fragmented DNA were elevated. Aqueous seed extract of Hunteria umbellata significantly ameliorated the high fructose diet-mediated alterations.
   Conclusions: From this study, it is concluded that aqueous seed extract of Hunteria umbellata possesses hypoglycemic, hypolipidemic and antioxidants abilities as evident from its capability to extenuate insulin resistance, dyslipidemia, inflammation and oxidative stress in high-fructose diet-induced metabolic syndrome rats.
C1 [Ajiboye, T. O.; Hussaini, A. A.; Nafiu, B. Y.; Ibitoye, O. B.] Hikmah Univ, Dept Biol Sci, Antioxidants Free Radicals Funct Foods & Toxicol, florin, Nigeria.
RP Ajiboye, TO (corresponding author), Hikmah Univ, Dept Biol Sci, Antioxidants Free Radicals Funct Foods & Toxicol, florin, Nigeria.
EM ajiboyeyong@yahoo.com; 1203BI020@alhikmah.edu.ng;
   1103BI021@alhilcmah.edu.ng; ojeyemisi@yahoo.com
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NR 60
TC 15
Z9 15
U1 1
U2 11
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0378-8741
EI 1872-7573
J9 J ETHNOPHARMACOL
JI J. Ethnopharmacol.
PD FEB 23
PY 2017
VL 198
BP 184
EP 193
DI 10.1016/j.jep.2016.11.043
PG 10
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA EP4PT
UT WOS:000397363100021
PM 27894971
DA 2025-06-11
ER

PT J
AU Faienza, MF
   Francavilla, R
   Goffredo, R
   Ventura, A
   Marzano, F
   Panzarino, G
   Marinelli, G
   Cavallo, L
   Di Bitonto, G
AF Faienza, Maria Felicia
   Francavilla, Ruggiero
   Goffredo, Rocco
   Ventura, Annamaria
   Marzano, Flaviana
   Panzarino, Gianvito
   Marinelli, Grazia
   Cavallo, Luciano
   Di Bitonto, Giovanna
TI Oxidative Stress in Obesity and Metabolic Syndrome in Children and
   Adolescents
SO HORMONE RESEARCH IN PAEDIATRICS
LA English
DT Article
DE Oxidative stress; Obesity; Metabolic syndrome
ID CARDIOVASCULAR-DISEASE; INSULIN-RESISTANCE; PEDIATRIC-PATIENTS;
   ATHEROSCLEROSIS; WEIGHT; RISK; HYPERTENSION; INFLAMMATION; ACTIVATION;
   ADIPOSITY
AB Background/Aims: The aim of this study was to investigate the alterations in the oxidant/antioxidant status in obese children with and without metabolic syndrome (MetS). Methods: We recruited 25 Caucasian obese children with MetS, 30 Caucasian children with simple obesity and a control group of 30 Caucasian children. We performed diacron-reactive oxygen metabolites (d-ROMs) test and biological antioxidant potential (BAP) test in order to evaluate the oxidant-antioxidant status in recruited patients. Results: dROM level was significantly higher in obese children with and without MetS (p = 0.005). The total antioxidant capacity (BAP level) was reduced in MetS and noMetS children compared to controls (p = 0.009). The subjects without MetS had higher d-ROMs test and lower BAP/d-ROMs ratio than subjects with MetS (although not significant). The ratio BAP/d-ROMs was higher in controls than noMetS and MetS children (p < 0.0001). d-ROM level was higher in prepubertal subjects with MetS than pubertal ones (p = 0.03). A direct correlation was found between d-ROM levels and BMI SDS (p = 0.0005), while an inverse correlation was found between BAP and BMI SDS (p = 0.004) and BAP/d-ROMs and BMI SDS (p = 0.0001). Conclusions: This result confirms that fat accumulation plays a key role in the pathogenesis of systemic oxidative stress already during pediatric age. Copyright (C) 2012 S. Karger AG, Basel
C1 [Faienza, Maria Felicia; Francavilla, Ruggiero; Goffredo, Rocco; Ventura, Annamaria; Marzano, Flaviana; Panzarino, Gianvito; Marinelli, Grazia; Cavallo, Luciano; Di Bitonto, Giovanna] Univ Bari A Moro, Dept Biomed Sci & Human Oncol, IT-70100 Bari, Italy.
C3 Universita degli Studi di Bari Aldo Moro
RP Faienza, MF (corresponding author), Univ Bari A Moro, Dept Biomed Sci & Human Oncol, Piazza G Cesare 11, IT-70100 Bari, Italy.
EM mf.faienza@endobiomol.uniba.it
RI cavallo, luigi/C-7272-2015; Faienza, Maria Felicia/K-6779-2016; marzano,
   flaviana/P-1654-2018; Francavilla, Ruggiero/S-1391-2019
OI Marinelli, Grazia/0000-0001-9163-2350; Faienza, Maria
   Felicia/0000-0002-1899-8337; cavallo, luciano/0000-0003-4787-8681;
   marzano, flaviana/0000-0002-2028-9214; Francavilla,
   Ruggiero/0000-0002-4603-974X
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NR 42
TC 87
Z9 90
U1 0
U2 17
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1663-2818
EI 1663-2826
J9 HORM RES PAEDIAT
JI Horm. Res. Paediatr.
PY 2012
VL 78
IS 3
BP 158
EP 164
DI 10.1159/000342642
PG 7
WC Endocrinology & Metabolism; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Pediatrics
GA 030HS
UT WOS:000310562400004
PM 23052543
DA 2025-06-11
ER

PT J
AU Yuan, F
   Hedayat, AF
   Ferguson, CM
   Lerman, A
   Lerman, LO
   Eirin, A
AF Yuan, Fang
   Hedayat, Ahmad F.
   Ferguson, Christopher M.
   Lerman, Amir
   Lerman, Lilach O.
   Eirin, Alfonso
TI Mitoprotection attenuates myocardial vascular impairment in porcine
   metabolic syndrome
SO AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
LA English
DT Article
DE elamipretide; metabolic syndrome; microvessels; mitochondria; myocardium
ID CORONARY ENDOTHELIAL DYSFUNCTION; EXPERIMENTAL HYPERCHOLESTEROLEMIA;
   RENOVASCULAR HYPERTENSION; OXIDATIVE STRESS; ARTERY STENOSIS;
   SKELETAL-MUSCLE; MITOCHONDRIA; INJURY; DISEASE; CELLS
AB Metabolic syndrome (MetS) leads to cardiac vascular injury, which may reflect in increased retention of endothelial progenitor cells (EPCs). Coronary endothelial cell (EC) mitochondria partly regulate vascular function and structure. We hypothesized that chronic mitoprotection would preserve EC mitochondria and attenuate coronary vascular injury and dysfunction in swine MetS. Pigs were studied after 16 wk of diet-induced MetS, MetS treated for the last 4 wk with the mitochondria-targeted peptide elamipretide (ELAM; 0.1 mg/kg sc once daily), and lean controls (n = 6 each). Cardiac remodeling and function were assessed in vivo by multidetector-computed tomography (CT), and coronary artery and sinus blood samples were collected. EC mitochondrial density, apoptosis, oxidative stress, endothelial nitric oxide synthase immunoreactivity, myocardial microvascular density (three-dimensional microcomputed tomography), and coronary endothelial function (organ bath) were assessed ex vivo. The number and arteriovenous gradient of CD34(+)/KDR+ EPCs were calculated by FACS (a negative net gradient indicating EPC retention). MetS and MetS + ELAM pigs developed similar MetS (obesity, hyperlipidemia, insulin resistance, and hypertension). EC mitochondrial density decreased in MetS animals compared with lean animals but normalized in MetS + ELAM animals. ELAM also attenuated EC oxidative stress and apoptosis and improved subendocardial microvascular density. ELAM-induced vasculoprotection was reflected by decreased coronary retention of EPCs. ELAM also partly improved endothelial nitric oxide synthase immunoreactivity, coronary endothelial function, and vessel maturity, whereas myocardial perfusion was unaffected. Chronic mitoprotection improved coronary EC mitochondrial density and decreased vascular remodeling and dysfunction. However, additional mitochondria-independent mechanisms likely contribute to MetS-induced cardiac vascular injury.
   NEW & NOTEWORTHY The present study shows that chronic mitoprotection preserved coronary endothelial cell mitochondria and decreased vascular injury, subendocardial microvascular loss, coronary retention of endothelial progenitor cells, and release of markers of vascular injury. However, myocardial perfusion remained blunted, suggesting that additional mitochondria-independent mechanisms likely contribute to metabolic syndrome-induced cardiac vascular injury.
C1 [Yuan, Fang; Hedayat, Ahmad F.; Ferguson, Christopher M.; Lerman, Lilach O.; Eirin, Alfonso] Mayo Clin, Div Nephrol & Hypertens, 200 First St SW, Rochester, MN 55905 USA.
   [Yuan, Fang] Zhengzhou Univ, Dept Cardiol, Peoples Hosp, Henan Prov Peoples Hosp, Zhengzhou, Henan, Peoples R China.
   [Lerman, Amir; Lerman, Lilach O.] Mayo Clin, Dept Cardiovasc Dis, Rochester, MN 55905 USA.
C3 Mayo Clinic; Zhengzhou University; Mayo Clinic
RP Eirin, A (corresponding author), Mayo Clin, Div Nephrol & Hypertens, 200 First St SW, Rochester, MN 55905 USA.
EM eirinmassat.alfonso@mayo.edu
RI Lerman, Lilach/M-4962-2017; Eirin, Alfonso/N-9873-2013
OI Eirin, Alfonso/0000-0002-3864-9644
FU Stealth BioTherapeutics; National Institutes of Health [DK-106427,
   DK-104273, HL-123160, DK-102325]
FX This work was supported by a grant from Stealth BioTherapeutics and
   National Institutes of Health Grants DK-106427, DK-104273, HL-123160,
   and DK-102325.
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NR 44
TC 17
Z9 17
U1 0
U2 5
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0363-6135
EI 1522-1539
J9 AM J PHYSIOL-HEART C
JI Am. J. Physiol.-Heart Circul. Physiol.
PD MAR
PY 2018
VL 314
IS 3
BP H669
EP H680
DI 10.1152/ajpheart.00431.2017
PG 12
WC Cardiac & Cardiovascular Systems; Physiology; Peripheral Vascular
   Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Physiology
GA GB1NX
UT WOS:000428818600027
PM 29196345
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Foong, HF
   Hamid, TA
   Ibrahim, R
   Haron, SA
   Shahar, S
AF Foong, Hui Foh
   Hamid, Tengku Aizan
   Ibrahim, Rahimah
   Haron, Sharifah Azizah
   Shahar, Suzana
TI Predicting cognitive function of the Malaysian elderly: a structural
   equation modelling approach
SO AGING & MENTAL HEALTH
LA English
DT Review
DE Cognitive function; biopsychosocial model; metabolic syndrome;
   psychosocial stress; structural equation modelling
ID MINI-MENTAL-STATE; METABOLIC SYNDROME; VASCULAR DEMENTIA; RISK-FACTORS;
   DEPRESSIVE SYMPTOMS; OLDER-ADULTS; CARDIOVASCULAR-DISEASE;
   BIOPSYCHOSOCIAL MODEL; DIABETES-MELLITUS; SOCIAL ENGAGEMENT
AB Objectives: The aim of this study was to identify the predictors of elderly's cognitive function based on biopsychosocial and cognitive reserve perspectives.Method: The study included 2322 community-dwelling elderly in Malaysia, randomly selected through a multi-stage proportional cluster random sampling from Peninsular Malaysia. The elderly were surveyed on socio-demographic information, biomarkers, psychosocial status, disability, and cognitive function. A biopsychosocial model of cognitive function was developed to test variables' predictive power on cognitive function. Statistical analyses were performed using SPSS (version 15.0) in conjunction with Analysis of Moment Structures Graphics (AMOS 7.0).Results: The estimated theoretical model fitted the data well. Psychosocial stress and metabolic syndrome (MetS) negatively predicted cognitive function and psychosocial stress appeared as a main predictor. Socio-demographic characteristics, except gender, also had significant effects on cognitive function. However, disability failed to predict cognitive function.Conclusion: Several factors together may predict cognitive function in the Malaysian elderly population, and the variance accounted for it is large enough to be considered substantial. Key factor associated with the elderly's cognitive function seems to be psychosocial well-being. Thus, psychosocial well-being should be included in the elderly assessment, apart from medical conditions, both in clinical and community setting.
C1 [Foong, Hui Foh; Hamid, Tengku Aizan; Ibrahim, Rahimah; Haron, Sharifah Azizah] Univ Putra Malaysia, Malaysian Res Inst Aging MyAging, Serdang, Malaysia.
   [Hamid, Tengku Aizan; Ibrahim, Rahimah] Univ Putra Malaysia, Fac Human Ecol, Dept Human Dev & Family Studies, Serdang, Malaysia.
   [Haron, Sharifah Azizah] Univ Putra Malaysia, Fac Human Ecol, Dept Resource Management & Consumer Studies, Serdang, Malaysia.
   [Shahar, Suzana] Univ Kebangsaan Malaysia, Sch Healthcare Sci, Dietet Programme, Fac Hlth Sci, Kuala Lumpur, Malaysia.
C3 Universiti Putra Malaysia; Universiti Putra Malaysia; Universiti Putra
   Malaysia; Universiti Kebangsaan Malaysia
RP Hamid, TA (corresponding author), Univ Putra Malaysia, Malaysian Res Inst Aging MyAging, Serdang, Malaysia.; Hamid, TA (corresponding author), Univ Putra Malaysia, Fac Human Ecol, Dept Human Dev & Family Studies, Serdang, Malaysia.
EM aizan@upm.edu.my
RI Foong, Hui/ABG-1711-2020; Haron, Sharifah Azizah/AAN-6909-2020
OI Shahar, Suzana/0000-0002-7191-9212; Ibrahim,
   Rahimah/0000-0003-2102-141X; Haron, Sharifah Azizah/0000-0003-2179-6338
FU Long Term Research Grant Scheme (LRGS), Ministry of Education Malaysia
   [LRGS/BU/2012/UKM-UKM/K01]
FX This work was supported by the Long Term Research Grant Scheme (LRGS),
   Ministry of Education Malaysia under Grant TUA-Neuro-protective Model
   for Health Longevity among Malaysian Elderly [project number
   LRGS/BU/2012/UKM-UKM/K01].
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NR 154
TC 15
Z9 15
U1 3
U2 44
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 1360-7863
EI 1364-6915
J9 AGING MENT HEALTH
JI Aging Ment. Health
PY 2018
VL 22
IS 1
BP 109
EP 120
DI 10.1080/13607863.2016.1231172
PG 12
WC Geriatrics & Gerontology; Gerontology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Psychiatry
GA FP6KU
UT WOS:000417735800015
PM 27732054
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Copeland, LA
   Pugh, MJ
   Hicks, PB
   Noel, PH
AF Copeland, Laurel Anne
   Pugh, Mary Jo
   Hicks, Paul B.
   Noel, Polly Hitchcock
TI Use of Obesity Related Care by Psychiatric Patients
SO PSYCHIATRIC SERVICES
LA English
DT Article
ID QUALITY-OF-LIFE; VETERANS-AFFAIRS; MENTAL-ILLNESS; HEALTH-CARE; WEIGHT;
   OVERWEIGHT; PATTERNS; SCHIZOPHRENIA; DISORDER; OUTCOMES
AB Objective: The objective of this study was to assess receipt of obesity care by patients with and without mental illness. Methods: The sample consisted of 254,051 obese primary care patients surviving through fiscal year (FY) 2006. Administrative data for Veterans Health Administration (VHA) patients who were obese in FY 2002 (body mass index >= 30) and received primary care in one of six selected VHA regions were included. Outcomes were receipt of obesity care and weight loss during FY 2002 FY 2006. Covariates included baseline mental illness (major depression, posttraumatic stress disorder, and substance use disorders; ICD-9-CM codes 290-311); psychotropic medications associated with weight gain; comorbidity; and demographic characteristics. Results: Most patients were male (95%), non-Hispanic white (80%), older than 50 (mean +/- SD=61 +/- 12) with comorbid hypertension (65%) and dyslipidemia (50%). One-fifth (20%) had mental illness, primarily depression (8%) or posttraumatic stress disorder (6%). Ten percent of the sample lost weight, and 7% gained >= 10% from baseline weight). Although one-third (34%) received obesity care during the study period, receipt of this care was more common among patients with psychiatric diagnoses (46% versus 31%). In multivariable analysis, psychiatric patients prescribed obesogenic psychotropic medications were more likely than other patients to receive obesity care (interaction effect). Conclusions: VITA efforts to help obese patients manage their weight appeared more common for patients prescribed obesogenic psychotropic medication, especially those with psychiatric diagnoses. The results of this study represent an unusual example in which psychiatric patients were relatively more likely to receive care addressing cardiometabolic risk factors. (Psychiatric Services 63:230-236, 2012; doi: 10.1176/appi.ps.201100221)
C1 [Copeland, Laurel Anne] Cent Texas Vet Hlth Care Syst, Ctr Appl Hlth Res, Temple, TX 76502 USA.
   [Hicks, Paul B.] Cent Texas Vet Hlth Care Syst, Dept Med, Temple, TX 76502 USA.
   [Copeland, Laurel Anne] Scott & White Healthcare, Temple, TX USA.
   [Pugh, Mary Jo; Noel, Polly Hitchcock] S Texas Vet Hlth Care Syst, VERDICT Res, San Antonio, TX USA.
   [Pugh, Mary Jo] UT Hlth Sci Ctr San Antonio, Dept Epidemiol & Biostat, San Antonio, TX USA.
   [Noel, Polly Hitchcock] UT Hlth Sci Ctr San Antonio, Div Clin Epidemiol, San Antonio, TX USA.
C3 US Department of Veterans Affairs; Veterans Health Administration (VHA);
   Audie L. Murphy Memorial Veterans Hospital; University of Texas System;
   University of Texas Health Science Center at San Antonio; University of
   Texas System; University of Texas Health Science Center at San Antonio
RP Copeland, LA (corresponding author), Cent Texas Vet Hlth Care Syst, Ctr Appl Hlth Res, 2102 Birdcreek Dr, Temple, TX 76502 USA.
EM laurelacopeland@gmail.com
RI Pugh, Mary/K-5336-2019; Hicks, Paul/AAF-6121-2021; Copeland,
   Laurel/C-3763-2017
OI Pugh, Mary Jo/0000-0003-4196-7763; Copeland, Laurel/0000-0002-9478-0209;
   Hicks, Paul/0000-0002-3921-9056; Noel, Polly/0000-0002-1519-7489
FU U.S. Department of Veterans Affairs (VA), Health Services Research and
   Development Services [IIR-05-121]; Central Texas Veterans Health Care
   System; Scott and White Healthcare (Temple, Texas); VERDICT Research at
   South Texas Veterans Health Care System; University of Texas Health
   Science Center San Antonio
FX This work was supported by the U.S. Department of Veterans Affairs (VA),
   Health Services Research and Development Services IIR-05-121, with
   additional support from Central Texas Veterans Health Care System, Scott
   and White Healthcare (Temple, Texas), VERDICT Research at the South
   Texas Veterans Health Care System, and the University of Texas Health
   Science Center San Antonio. The views expressed in this article are
   those of the authors and do not necessarily represent the views of the
   VA.
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NR 31
TC 11
Z9 11
U1 0
U2 2
PU AMER PSYCHIATRIC PUBLISHING, INC
PI WASHINGTON
PA 800 MAINE AVE SW, SUITE 900, WASHINGTON, DC 20024 USA
SN 1075-2730
EI 1557-9700
J9 PSYCHIAT SERV
JI Psychiatr. Serv.
PD MAR
PY 2012
VL 63
IS 3
BP 230
EP 236
DI 10.1176/appi.ps.201100221
PG 7
WC Health Policy & Services; Public, Environmental & Occupational Health;
   Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services; Public, Environmental & Occupational
   Health; Psychiatry
GA 917NV
UT WOS:000302185600007
PM 22307880
DA 2025-06-11
ER

PT J
AU Ekeuku, SO
   Azlina, MFN
   Chin, KY
AF Ekeuku, Sophia Ogechi
   Nur Azlina, Mohd Fahami
   Chin, Kok-Yong
TI Effects of Piper sarmentosum on Metabolic Syndrome and Its Related
   Complications: A Review of Preclinical Evidence
SO APPLIED SCIENCES-BASEL
LA English
DT Review
DE cholesterol; inflammation; oxidative stress; hypertension; obesity;
   diabetes
ID 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1; ASYMMETRIC DIMETHYLARGININE
   ADMA; ADIPOSE-SPECIFIC PROTEIN; HIGH-FAT DIET; OXIDATIVE STRESS;
   ENDOTHELIAL DYSFUNCTION; WATER EXTRACT; INDUCED HYPERTENSION; INSULIN
   SENSITIVITY; ADIPOCYTE SIZE
AB Featured Application
   This review illustrates the effects of Piper sarmentosum extract in the management of metabolic derangements constituting metabolic syndrome and their complications and suggests future direction to advance this field.
   Piper sarmentosum (PS) is a traditional medicinal herb used by South East Asians. It demonstrates promising properties against various non-communicable diseases and infectious agents due to its antioxidant and anti-inflammatory properties. Given that oxidative stress and inflammation are involved in developing and exacerbating metabolic syndrome (MetS) and its principal components (central obesity, hyperglycaemia, hypertension, and dyslipidaemia), PS could manage MetS and its complications. This review summarises the available literature on the effects of PS on principal components of MetS and their complications. The accumulated evidence suggests that PS prevented adiposity, hyperglycaemia, hypertension, and dyslipidaemia in preclinical studies mainly through its antioxidant and anti-inflammatory properties. It also protected against MetS-associated cardiovascular complications. This review has identified research gaps in this field and suggested future studies to guide interested researchers to explore further or affirm the therapeutic potential of PS. One of the most significant challenges to the medical use of PS is the absence of randomised controlled trials in humans. This study gap must be bridged before PS supplementation could be used to manage MetS in humans.
C1 [Ekeuku, Sophia Ogechi; Nur Azlina, Mohd Fahami; Chin, Kok-Yong] Univ Kebangsaan Malaysia, Fac Med, Dept Pharmacol, Kuala Lumpur 56000, Malaysia.
C3 Universiti Kebangsaan Malaysia
RP Chin, KY (corresponding author), Univ Kebangsaan Malaysia, Fac Med, Dept Pharmacol, Kuala Lumpur 56000, Malaysia.
EM chinkokyong@ppukm.ukm.edu.my
RI Mohamad, Nur-Vaizura/ABA-2933-2021; Chin, Kok-Yong/B-6309-2015;
   /ABI-7123-2020
OI Chin, Kok-Yong/0000-0001-6628-1552; Nur Azlina, Mohd
   Fahami/0000-0002-3458-0440; /0000-0002-5485-4592
FU Universiti Kebangsaan Malaysia through Research University Grant
   [GUP-2020-021]; Universiti Kebangsaan Malaysia
FX This research was funded by Universiti Kebangsaan Malaysia through
   Research University Grant (GUP-2020-021). Sophia Ogechi Ekeuku is a
   postdoctoral researcher funded by Universiti Kebangsaan Malaysia through
   FPR-1.
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NR 153
TC 4
Z9 4
U1 0
U2 5
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3417
J9 APPL SCI-BASEL
JI Appl. Sci.-Basel
PD NOV
PY 2021
VL 11
IS 21
AR 9860
DI 10.3390/app11219860
PG 22
WC Chemistry, Multidisciplinary; Engineering, Multidisciplinary; Materials
   Science, Multidisciplinary; Physics, Applied
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Engineering; Materials Science; Physics
GA WX4OY
UT WOS:000718578200001
OA gold
DA 2025-06-11
ER

PT J
AU Griffin, DM
   Bitner, BR
   Ii, ZC
   Marcano, D
   Berlin, JM
   Kent, TA
   Tour, JM
   Samson, SL
   Pautler, RG
AF Griffin, Deric M.
   Bitner, Brittany R.
   Ii, Zachary Criss
   Marcano, Daniela
   Berlin, Jacob M.
   Kent, Thomas A.
   Tour, James M.
   Samson, Susan L.
   Pautler, Robia G.
TI Use of a bioengineered antioxidant in mouse models of metabolic syndrome
SO EXPERT OPINION ON INVESTIGATIONAL DRUGS
LA English
DT Article
DE Obesity; metabolic syndrome; hyperglycemia; reactive oxygen species;
   oxidative stress; antioxidant; insulin resistance; prediabetes
ID NONALCOHOLIC FATTY LIVER; HYDROPHILIC CARBON CLUSTERS; OXIDATIVE STRESS;
   VITAMIN-E; CEREBROVASCULAR DYSFUNCTION; INSULIN-RESISTANCE; DISEASE;
   JNK; STEATOHEPATITIS; PATHOGENESIS
AB Background: Oxidative stress has been implicated in metabolic syndrome (MetS); however, antioxidants such as vitamin E have had limited success in the clinic. This prompts the question of what effects amore potent antioxidant might produce. A prime candidate is the recently developed bioengineered antioxidant, poly(ethylene glycol)-functionalizedhydrophilic carbon clusters (PEG-HCCs), which are capable of neutralizing the reactive oxygen species (ROS) superoxide anion and hydroxyl radical at10(6)/molecule of PEG-HCC. In this project, we tested the potential of PEG-HCCs as a possible therapeutic for MetS. Results: PEG-HCC treatment lessened lipid peroxidation, aspartate aminotransferase levels, non-fastingblood glucose levels, and JNK phosphorylation inob/ob mice. PEG-HCC-treated WT mice had an increased response to insulin by insulin tolerance tests and adecrease in blood glucose by glucose tolerance tests. These effects were not observed in HFD-fed mice, regardless of treatment. PEG-HCCs were observed in the interstitial space of liver, spleen, skeletal muscle, and adipose tissue. No significant difference was shown in gluconeogenesis or inflammatory gene expression between treatment and dietary groups. Expert Opinion: PEG-HCCs improved some parameters of disease possibly due to a resulting increase in peripheral insulin sensitivity. However, additional studies are needed to elucidate how PEG-HCCsare producing these effects.
C1 [Griffin, Deric M.; Bitner, Brittany R.; Ii, Zachary Criss; Kent, Thomas A.; Pautler, Robia G.] Baylor Coll Med, Interdept Program Translat Biol & Mol Med, Houston, TX 77030 USA.
   [Marcano, Daniela; Berlin, Jacob M.; Tour, James M.; Samson, Susan L.] Rice Univ, Dept Chem, Houston, TX USA.
   [Marcano, Daniela; Berlin, Jacob M.; Tour, James M.] Rice Univ, Smalley Curl Inst, Houston, TX USA.
   [Marcano, Daniela; Berlin, Jacob M.; Tour, James M.] Rice Univ, Nanocarbon Ctr, Houston, TX USA.
   [Berlin, Jacob M.] City Hope Natl Med Ctr, Mol Med, Duarte, CA USA.
   [Kent, Thomas A.] Baylor Coll Med, Dept Neurol, Houston, TX 77030 USA.
   [Kent, Thomas A.] Michael E DeBakey VA Med Ctr, Ctr Translat Res Inflammatory Dis, Houston, TX USA.
   [Samson, Susan L.] Baylor Coll Med, Dept Med, Houston, TX 77030 USA.
   [Pautler, Robia G.] Baylor Coll Med, Dept Mol Physiol & Biophys, One Baylor Plaza, Houston, TX 77030 USA.
C3 Baylor College of Medicine; Rice University; Rice University; Rice
   University; City of Hope; Baylor College of Medicine; Baylor College of
   Medicine; Baylor College Medical Hospital; Baylor College of Medicine;
   Baylor College of Medicine
RP Pautler, RG (corresponding author), Baylor Coll Med, Dept Mol Physiol & Biophys, One Baylor Plaza, Houston, TX 77030 USA.
EM Rpautler@bcm.edu
RI Tour, James/AGW-1519-2022
FU HHMI Gilliam fellowship; Department of Defense through the Mission
   Connect Mild Traumatic Brain Injury Consortium [W81XWH-08-2-0143];
   Alliance for NanoHealth [W81XWH-09-02-0139]; National Institute of
   Diabetes and Digestive and Kidney Diseases [R21DK093802]; National
   Institute of Neurological Disorders and Stroke [R21NS084290,
   R01NS094535]; Welch Foundation [BE-0048]
FX D Griffin was funded by an HHMI Gilliam fellowship. The work at Rice
   University was funded by the Department of Defense through the Mission
   Connect Mild Traumatic Brain Injury Consortium (W81XWH-08-2-0143) and
   the Alliance for NanoHealth (W81XWH-09-02-0139). The work at BCM was
   funded by the National Institute of Diabetes and Digestive and Kidney
   Diseases (R21DK093802) and the National Institute of Neurological
   Disorders and Stroke (R21NS084290 and R01NS094535) and Welch Foundation
   Grant BE-0048 (T.A.K.).
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NR 63
TC 0
Z9 0
U1 0
U2 3
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1354-3784
EI 1744-7658
J9 EXPERT OPIN INV DRUG
JI Expert Opin. Investig. Drugs
PD FEB 1
PY 2020
VL 29
IS 2
SI SI
BP 209
EP 219
DI 10.1080/13543784.2020.1716216
EA JAN 2020
PG 11
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA KH7EB
UT WOS:000508306400001
PM 31937152
DA 2025-06-11
ER

PT J
AU Mangurian, C
   Modlin, C
   Williams, L
   Essock, S
   Riano, NS
   Shumway, M
   Newcomer, JW
   Dilley, JW
   Schillinger, D
AF Mangurian, Christina
   Modlin, Chelsea
   Williams, Lindsey
   Essock, Susan
   Riano, Nicholas S.
   Shumway, Martha
   Newcomer, John W.
   Dilley, James W.
   Schillinger, Dean
TI A Doctor is in the House: Stakeholder Focus Groups About Expanded Scope
   of Practice of Community Psychiatrists
SO COMMUNITY MENTAL HEALTH JOURNAL
LA English
DT Article
DE Severe mental illness; Stakeholder focus group; Metabolic screening;
   Barriers to care
ID CATIE SCHIZOPHRENIA TRIAL; PRIMARY-CARE; MENTAL-ILLNESS; MEDICAL-CARE;
   RISK; SERVICES; PEOPLE; PREVALENCE; MANAGEMENT; BARRIERS
AB We sought to understand stakeholder perspectives on barriers to metabolic screening for people with severe mental illness. We additionally assessed the feasibility of expanding psychiatrists' scope of practice to include treatment of cardiometabolic abnormalities. We conducted four focus groups among patients with severe mental illness, community psychiatrists, primary care providers, and public health administrators. Focus group transcripts were thematically analyzed. Three domains emerged: challenges with patient navigation of the complex health care system, problem list prioritization difficulties, and concern that treatment of cardiometabolic abnormalities were beyond the scope of practice of psychiatrists. Stakeholders agreed that navigating the health care system was challenging for this population and led to undertreatment of cardiometabolic risk factors. Expansion of psychiatrists' scope of practice within community mental health appears acceptable to patients and may be a mechanism to improve cardiometabolic care among people with severe mental illness.
C1 [Mangurian, Christina; Modlin, Chelsea; Williams, Lindsey; Riano, Nicholas S.; Shumway, Martha; Dilley, James W.] Univ Calif San Francisco, 1001 Potrero Ave,7M8, San Francisco, CA 94110 USA.
   [Essock, Susan; Schillinger, Dean] Columbia Univ, New York State Psychiat Inst, 1051 Riverside Dr,Unit 100, New York, NY USA.
   [Newcomer, John W.] Florida Atlantic Univ, 777 Glades Rd,BC-71 Rm 241, Boca Raton, FL USA.
C3 University of California System; University of California San Francisco;
   New York State Psychiatry Institute; Columbia University; State
   University System of Florida; Florida Atlantic University
RP Mangurian, C (corresponding author), Univ Calif San Francisco, 1001 Potrero Ave,7M8, San Francisco, CA 94110 USA.
EM christina.mangurian@ucsf.edu
RI Riano, Nicholas/LIH-0953-2024
OI Modlin, Chelsea/0000-0001-9005-9812; Newcomer, John/0000-0003-2153-9382
FU National Institutes of Mental Health [K23MH093689]; UCSF Hellman Fellows
   Award for Early-Career Faculty; National Center for Research Resources;
   National Center for Advancing Translational Sciences; Office of the
   Director, National Institutes of Health, through UCSF-CTSI [KL2
   RR024130]; UCSF Public Psychiatry Fellowship at ZSFG; Otsuka America
   Pharmaceutical Inc.; Indivior Pharmaceuticals; NIH Center Grant from the
   National Institute of Diabetes and Digestive and Kidney Diseases for The
   Health Delivery Systems Center for Diabetes Translational Research
   (CDTR) [P30DK092924]; NIH/National Institute of Minority Health and
   Health Disparities (NIMHD) Comprehensive Center of Excellence for Health
   and Risk in Minority Youth and Young Adults [P60MD006902]
FX Author A was supported by the National Institutes of Mental Health
   (K23MH093689), the UCSF Hellman Fellows Award for Early-Career Faculty,
   and the National Center for Research Resources, the National Center for
   Advancing Translational Sciences, and the Office of the Director,
   National Institutes of Health, through UCSF-CTSI Grant Number KL2
   RR024130. Author E was supported by the National Institutes of Mental
   Health (K23MH093689), and by the UCSF Public Psychiatry Fellowship at
   ZSFG. Author G has grant support from Otsuka America Pharmaceutical
   Inc., consulting fees from Indivior Pharmaceuticals, and he serves on a
   Data Safety Monitoring Board for Amgen, outside the submitted work.
   Author I was supported by the NIH Center Grant from the National
   Institute of Diabetes and Digestive and Kidney Diseases for The Health
   Delivery Systems Center for Diabetes Translational Research (CDTR)
   (P30DK092924) and the NIH/National Institute of Minority Health and
   Health Disparities (NIMHD) Comprehensive Center of Excellence for Health
   and Risk in Minority Youth and Young Adults (P60MD006902). The remaining
   authors declare that they have no conflicts of interest.
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NR 43
TC 9
Z9 9
U1 0
U2 3
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0010-3853
EI 1573-2789
J9 COMMUNITY MENT HLT J
JI Community Ment. Health J.
PD JUL
PY 2018
VL 54
IS 5
BP 507
EP 513
DI 10.1007/s10597-017-0198-4
PG 7
WC Health Policy & Services; Public, Environmental & Occupational Health;
   Psychiatry
WE Social Science Citation Index (SSCI)
SC Health Care Sciences & Services; Public, Environmental & Occupational
   Health; Psychiatry
GA GK2GW
UT WOS:000435946400001
PM 29185153
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Calugi, S
   Dalle Grave, R
   Marchesini, G
AF Calugi, S.
   Dalle Grave, R.
   Marchesini, G.
TI Night eating syndrome in class II-III obesity: metabolic and
   psychopathological features
SO INTERNATIONAL JOURNAL OF OBESITY
LA English
DT Article
DE night eating; depression; binge eating; psychological distress; obesity
   treatment; eating disorders
ID WEIGHT-LOSS; PREVALENCE; DEPRESSION; PATTERNS; DISORDER; SNACKING;
   HUNGER; IMPACT
AB Objective: To investigate the relationship of metabolic disorders and psychological features with the night eating syndrome (NES) in individuals with moderate-to-severe obesity.
   Design: Cross-sectional observation.
   Subjects: A total of 266 consecutive participants with class II-III obesity, entering an inpatient weight loss program.
   Measurements: Participants who reported consuming either a large amount of their caloric intake after the evening meal (roughly self-assessed as >= 25% of daily calories) or the presence of nocturnal feeding at the Night Eating Questionnaire (NEQ) (N = 49) were interviewed by the Night Eating Syndrome History and Inventory (NESHI). Assessment also included the clinical/biochemical parameters of the metabolic syndrome and several questionnaires of psychopathology. NES was diagnosed by NESHI criteria (evening hyperphagia (>= 25% of daily food intake after the evening meal) and/or waking at night to eat at least three times a week) in the last 3 months.
   Results: Twenty-seven participants (10.1%) met NESHI criteria. Differences were not observed between participants with and without NES as to age, body mass index (BMI), prevalence of metabolic syndrome, Binge Eating Scale and Body Shape Questionnaire. NES participants had significantly higher scores of Beck Depression Inventory (BDI) and Impact of Weight on Quality of Life (IWQOL). Among NES cases, the BDI score was indicative of moderate depression in 18.5% of cases and of severe depression in 44.4%. Logistic regression analysis, adjusted for confounders, identified the BDI score as the only variable significantly associated with the diagnosis of NES.
   Conclusion: Diagnosing NES does not help identify obese individuals with specific medical complications, but indicates more severe psychological distress and depression. International Journal of Obesity (2009) 33, 899-904; doi: 10.1038/ijo.2009.105; published online 9 June 2009
C1 [Marchesini, G.] Alma Mater Univ Bologna, Unit Clin Dietet, Policlin S Orsola, Via Massarenti 9, I-40138 Bologna, Italy.
   [Calugi, S.; Dalle Grave, R.] Villa Garda Hosp, Dept Eating & Weight Disorder, Garda, Vr, Italy.
C3 University of Bologna; IRCCS Azienda Ospedaliero-Universitaria di
   Bologna
RP Marchesini, G (corresponding author), Alma Mater Univ Bologna, Unit Clin Dietet, Policlin S Orsola, Via Massarenti 9, I-40138 Bologna, Italy.
EM giulio.marchesini@unibo.it
RI Calugi, Simona/S-5331-2018; Dalle Grave, Riccardo/L-4506-2013
OI Marchesini, Giulio/0000-0003-2407-9860; Dalle Grave,
   Riccardo/0000-0002-9796-3721
CR Adami G E, 1997, Eat Weight Disord, V2, P203
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NR 35
TC 40
Z9 50
U1 0
U2 4
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0307-0565
EI 1476-5497
J9 INT J OBESITY
JI Int. J. Obes.
PD AUG
PY 2009
VL 33
IS 8
BP 899
EP 904
DI 10.1038/ijo.2009.105
PG 6
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 481HU
UT WOS:000268799200012
PM 19506562
DA 2025-06-11
ER

PT J
AU Luckhoff, HK
   du Plessis, S
   van den, HL
   Emsley, R
   Seedat, S
AF Luckhoff, Hilmar Klaus
   du Plessis, Stefan
   Leigh van den, Heuvel
   Emsley, Robin
   Seedat, Soraya
TI Independent effects of posttraumatic stress disorder diagnosis and
   metabolic syndrome status on prefrontal cortical thickness and
   subcortical gray matter volumes
SO DIALOGUES IN CLINICAL NEUROSCIENCE
LA English
DT Article
DE Metabolic syndrome; post-traumatic stress disorder; prefrontal cortex;
   triglycerides; ventral diencephalon
ID BODY-MASS INDEX; HUMAN CEREBRAL-CORTEX; DIABETES-MELLITUS; OBESITY;
   BRAIN; PREVALENCE; ABNORMALITIES; HYPERTENSION; HIPPOCAMPUS; POPULATION
AB Introduction Posttraumatic stress disorder (PTSD) and metabolic syndrome (MetS) are associated with overlapping brain structural differences. These often involve brain structures involved in the regulation of appetite, food intake, satiety, and reward processing. We examined the individual and interactive effects of PTSD diagnosis and MetS on cortical thickness and subcortical gray matter volumes in patients with PTSD (n = 104) compared to trauma-exposed controls (n = 97). Methods Multivariate models were constructed for FreeSurfer-generated prefrontal cortical thickness and subcortical gray matter regions-of-interest (ROIs) to explore the effects of PTSD diagnosis and MetS as predictors, adjusting for relevant socio-demographic and clinical covariates. Individual prefrontal cortical and subcortical limbic ROIs were also selected based on a priori evidence of their involvement in both PTSD and MetS. Results The mean age of the sample (n = 201; 78% female) was 41.6 (SD, 13.1) years. PTSD and MetS status showed independent associations with prefrontal cortical thickness and subcortical gray matter volumes across multiple ROIs, adjusting for age, sex, scanner sequence, alcohol, and tobacco use. Conclusions PTSD and MetS are independently associated with brain structural differences, including thinner prefrontal cortical thickness and smaller subcortical gray matter volumes, across multiple ROIs implicated in the hedonic and homeostatic regulation of food intake.
C1 [Luckhoff, Hilmar Klaus; du Plessis, Stefan; Leigh van den, Heuvel; Emsley, Robin; Seedat, Soraya] Stellenbosch Univ, Fac Med & Hlth Sci, Dept Psychiat, Cape Town, South Africa.
   [Leigh van den, Heuvel] Stellenbosch Univ, Fac Med & Hlth Sci, Dept Psychiat, SAMRC Genom & Brain Disorders Unit, Cape Town, South Africa.
C3 Stellenbosch University; Stellenbosch University
RP Luckhoff, HK (corresponding author), Stellenbosch Univ, Fac Med & Hlth Sci, Dept Psychiat, Cape Town, South Africa.
EM luckhoffh@sun.ac.za
OI Luckhoff, Hilmar Klaus/0000-0002-1623-056X
FU South African Medical Research Council from the South African National
   Treasury [MRC-RFA-IFSP01-2013/SHARED ROOTS]; SAMRC Self- Initiated
   Research Grant; National Research Foundation of South Africa Thuthuka
   grant; South African Research Chairs Initiative in PTSD - Department of
   Science and Technology; National Research Foundation; German Research
   Foundation [KI-537/371, STA 1213/61]
FX This work was supported by the South African Medical Research Council
   for the Shared Roots' Flagship Project through funding received from the
   South African National Treasury under its Economic Competitiveness and
   Support Package [grant number MRC-RFA-IFSP-01-2013/SHARED ROOTS]. Its
   contents are solely the responsibility of the authors and do not
   necessarily represent the official views of the South African Medical
   Research Council. The work by Leigh van den Heuvel was made possible
   through funding by the South African Medical Research Council through
   its Division of Research Capacity Development under the SAMRC CLINICIAN
   RESEARCHER (MD PHD) SCHOLARSHIP PROGRAM from funding received from the
   South African National Treasury. Leigh van den Heuvel is also supported
   by a SAMRC Self- Initiated Research Grant and by a National Research
   Foundation of South Africa Thuthuka grant. The content hereof is the
   sole responsibility of the authors and do not necessarily represent the
   official views of the SAMRC or the funders. Soraya Seedat is supported
   by the South African Research Chairs Initiative in PTSD funded by the
   Department of Science and Technology and the National Research
   Foundation. The research reported in this publication was supported by
   the German Research Foundation [grant number KI-537/37-1], [grant number
   STA 1213/6-1].
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NR 58
TC 1
Z9 1
U1 0
U2 8
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1294-8322
EI 1958-5969
J9 DIALOGUES CLIN NEURO
JI Dialogues Clin. Neurosci.
PD DEC 31
PY 2023
VL 25
IS 1
BP 64
EP 74
DI 10.1080/19585969.2023.2237525
PG 11
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA N7VY7
UT WOS:001039057300001
PM 37497602
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Lopez-Moreno, J
   Quintana-Navarro, GM
   Camargo, A
   Jimenez-Lucena, R
   Delgado-Lista, J
   Marin, C
   Tinahones, FJ
   Striker, GE
   Roche, HM
   Perez-Martinez, P
   Lopez-Miranda, J
   Yubero-Serrano, EM
AF Lopez-Moreno, Javier
   Quintana-Navarro, Gracia M.
   Camargo, Antonio
   Jimenez-Lucena, Rosa
   Delgado-Lista, Javier
   Marin, Carmen
   Tinahones, Francisco J.
   Striker, Gary E.
   Roche, Helen M.
   Perez-Martinez, Pablo
   Lopez-Miranda, Jose
   Yubero-Serrano, Elena M.
TI Dietary fat quantity and quality modifies advanced glycation end
   products metabolism in patients with metabolic syndrome
SO MOLECULAR NUTRITION & FOOD RESEARCH
LA English
DT Article
DE Advanced glycation end products; Dietary fat; Inflammation; Metabolic
   syndrome; Oxidative stress
ID INSULIN-RESISTANCE; OXIDATIVE STRESS; CARDIOVASCULAR-DISEASE;
   MEDITERRANEAN DIET; RANDOMIZED-TRIAL; ADIPOSE-TISSUE; RISK; HEALTHY;
   FOODS; INTERVENTION
AB Scope: Advanced glycation end products (AGEs) increase in dysmetabolic conditions. Lifestyle, including diet, has shown be effective in preventing the development of metabolic syndrome (MetS). We investigated whether AGE metabolism is affected by diets with different fat quantity and quality in MetS patients.
   Methods and results: A randomized, controlled trial assigned 75 MetS patients to one of four diets: high SFA (HSFA), high MUFA (HMUFA), and two low-fat, high-complex carbohydrate diets (LFHCC) supplemented with long-chain n-3 PUFA or placebo for 12-weeks each. Dietary and serum AGE [methylglyoxal (MG: lysine-MG-H1) and N-carboxymethyllysine] levels and gene expression related to AGE metabolism in peripheral blood mononuclear cells (AGER1, RAGE, GloxI, and Sirt1 mRNA) were determined. HMUFA diet reduced serum AGE (sAGE) and RAGE mRNA, increased AGER1 and GloxI mRNA levels compared to the other diets. LFHCC n-3 diet reduced sAGE levels and increased AGER1mRNA levels compared to LFHCC and HSFA diets. Multiple regression analyses showed that sMG and AGER1 mRNA appeared as significant predictors of oxidative stress/ inflammation-related parameters.
   Conclusions: Low AGE content in HMUFA diet reduces sAGEs and modulates the gene expression related to AGE metabolism in MetS patients, which may be used as a therapeutic approach to reduce the incidence of MetS and related chronic diseases.
C1 [Lopez-Moreno, Javier; Quintana-Navarro, Gracia M.; Camargo, Antonio; Jimenez-Lucena, Rosa; Delgado-Lista, Javier; Marin, Carmen; Perez-Martinez, Pablo; Lopez-Miranda, Jose; Yubero-Serrano, Elena M.] Univ Cordoba, Reina Sofia Univ Hosp, Maimonides Biomed Res Inst Cordoba IMIBIC, Lipids & Atherosclerosis Unit, Cordoba, Spain.
   [Lopez-Moreno, Javier; Quintana-Navarro, Gracia M.; Camargo, Antonio; Jimenez-Lucena, Rosa; Delgado-Lista, Javier; Marin, Carmen; Tinahones, Francisco J.; Perez-Martinez, Pablo; Lopez-Miranda, Jose; Yubero-Serrano, Elena M.] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr CIBEROBN, Madrid, Spain.
   [Tinahones, Francisco J.] Univ Malaga, Virgen de la Victoria Hosp, Biomed Res Inst Malaga IBIMA, Malaga, Spain.
   [Striker, Gary E.] Icahn Sch Med Mt Sinai, Div Expt Diabet & Aging, Dept Geriatr, Sch Med, New York, NY 10029 USA.
   [Roche, Helen M.] Univ Coll Dublin, Sch Publ Hlth Physiotherapy & Sports Sci, UCD Inst Food & Hlth, Nutrigen Res Grp,UCD Conway Inst, Dublin, Ireland.
C3 Universidad de Cordoba; Instituto de Salud Carlos III; CIBER - Centro de
   Investigacion Biomedica en Red; CIBEROBN; Instituto de Investigacion
   Biomedica de Malaga y Plataforma en Nanomedicina (IBIMA); Universidad de
   Malaga; Icahn School of Medicine at Mount Sinai; University College
   Dublin
RP Lopez-Miranda, J; Yubero-Serrano, EM (corresponding author), Univ Cordoba, Reina Sofia Univ Hosp, Maimonides Biomed Res Inst Cordoba IMIBIC, Lipids & Atherosclerosis Unit, Cordoba, Spain.; Lopez-Miranda, J; Yubero-Serrano, EM (corresponding author), Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr CIBEROBN, Madrid, Spain.
EM jlopezmir@uco.es; helese35@hotmail.com
RI Lopez-Miranda, Jose/Y-8306-2019; Delgado-Lista, Javier/KAM-7412-2024;
   Roche, Helen/AAF-4164-2019; YUBERO, ELENA/AFM-2738-2022; Marin Hinojosa,
   Carmen/AFO-1294-2022; Tinahones, Francisco/AAB-2882-2020; Camargo
   Garcia, Antonio/G-9720-2015; Perez Martinez, Pablo/AEL-6176-2022
OI Lopez-Miranda, Jose/0000-0002-8844-0718; Yubero-Serrano, Elena
   M/0000-0002-2733-5359; Camargo Garcia, Antonio/0000-0002-0415-4184;
   Delgado Lista, Francisco Javier/0000-0002-2982-2716; Tinahones,
   Francisco J/0000-0001-6871-4403; Jimenez-Lucena,
   Rosa/0000-0001-7115-3117; Roche, Helen/0000-0002-0628-3318;
   QUINTANA-NAVARRO, GRACIA MARIA/0000-0003-4413-4062; Perez Martinez,
   Pablo/0000-0001-7716-8117
FU Ministerio de Economia y Competitividad [AGL2012/39615, PIE14/00005,
   PIE14/00031]; Consejeria de Salud, Junta de Andalucia [PI0193/09];
   Proyecto de Excelencia, Consejeria de Economia, Innovacion, Ciencia y
   Empleo [CVI-7450]; European Community (NUTRITECH European Integrated
   Project) [289511]; Fondo Europeo de Desarrollo Regional (FEDER);
   Ministerio de Ciencia e Innovacion [AGL2004-07907, AGL2006-01979,
   AGL2009-12270]; Ministerio de Ciencia y Competitividad [PIE14/00005,
   PIE14/00031, AGL2012-39615, FIS PI10/01041, FIS PI13/00023]; Consejeria
   de Innovacion, Ciencia y Empresa, Junta de Andalucia [P06-CTS-01425,
   PI-0193/09, PI-0252/09, PI-0058/10]; Merck Serono; Fundacion 2000
   (Clinical research in Cardiometabolic); Science Foundation Ireland [SFI
   PI/11/1119]; European Commission FP6 [FOOD-CT-2003-505944]
FX Ministerio de Economia y Competitividad (AGL2012/39615, PIE14/00005,
   PIE14/00031 to J.L.M.); Consejeria de Salud, Junta de Andalucia
   (PI0193/09 to J.L.-M.); Proyecto de Excelencia, Consejeria de Economia,
   Innovacion, Ciencia y Empleo (CVI-7450 to J.L.-M.); Research Grant from
   the European Community (NUTRITECH European Integrated Project-289511)
   and Fondo Europeo de Desarrollo Regional (FEDER).Supported in part by
   research grants from the Ministerio de Ciencia e Innovacion
   (AGL2004-07907, AGL2006-01979, AGL2009-12270 to J.L.-M.), Ministerio de
   Ciencia y Competitividad (AGL2012-39615, PIE14/00005, PIE14/00031 to
   JL-M, FIS PI10/01041 to P.P.-M., FIS PI13/00023 to J.D.-L.), Consejeria
   de Innovacion, Ciencia y Empresa, Junta de Andalucia (P06-CTS-01425 and
   PI-0193/09 to J.L.-M., PI-0252/09 to J.D.-L., and PI-0058/10 to
   P.P.-M.), Proyecto de Excelencia, Consejeria de Economia, Innovacion,
   Ciencia y Empleo (CVI-7450 to J.L.-M.); Merck Serono and Fundacion 2000
   (Clinical research in Cardiometabolic to P.P.-M.), Research Grant from
   the European Community (NUTRITECH European Integrated Project-289511)
   and Fondo Europeo de Desarrollo Regional (FEDER). The CIBEROBN is an
   initiative of the Instituto de Salud Carlos III, Madrid, Spain. HMR is
   supported by Science Foundation Ireland (SFI PI/11/1119). The authors
   acknowledge LIPGENE subjects and investigators, funded by European
   Commission FP6 (FOOD-CT-2003-505944).
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NR 55
TC 36
Z9 39
U1 0
U2 18
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1613-4125
EI 1613-4133
J9 MOL NUTR FOOD RES
JI Mol. Nutr. Food Res.
PD AUG
PY 2017
VL 61
IS 8
AR 1601029
DI 10.1002/mnfr.201601029
PG 12
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA FD7NS
UT WOS:000407713400019
PM 28233454
DA 2025-06-11
ER

PT J
AU Ravic, M
   Srejovic, I
   Novakovic, J
   Andjic, M
   Sretenovic, J
   Muric, M
   Nikolic, M
   Bolevich, S
   Kasabov, KA
   Fisenko, VP
   Stojanovic, A
   Jakovljevic, V
AF Ravic, Marko
   Srejovic, Ivan
   Novakovic, Jovana
   Andjic, Marijana
   Sretenovic, Jasmina
   Muric, Maja
   Nikolic, Marina
   Bolevich, Sergey
   Kasabov, Kirill Alekseevich
   Fisenko, Vladimir Petrovich
   Stojanovic, Aleksandra
   Jakovljevic, Vladimir
TI Effect of GLP-1 Receptor Agonist on Ischemia Reperfusion Injury in Rats
   with Metabolic Syndrome
SO PHARMACEUTICALS
LA English
DT Article
DE metabolic syndrome; GLP-1 agonists; oxidative stress; cardioprotection
ID GLUCAGON-LIKE PEPTIDE-1; OXIDATIVE STRESS; MYOCARDIAL-INFARCTION;
   EXENATIDE; DULAGLUTIDE; HEART; MITOCHONDRIA; ACTIVATION; PROTECTION;
   RELEASE
AB Metabolic syndrome (MetS) represents an important factor that increases the risk of myocardial infarction, and more severe complications. Glucagon Like Peptide-1 Receptor Agonists (GLP-1RAs) exhibit cardioprotective potential, but their efficacy in MetS-related myocardial dysfunction has not been fully explored. Therefore, we aimed to assess the effects of exenatide and dulaglutide on heart function and redox balance in MetS-induced rats. Twenty-four Wistar albino rats with induced MetS were divided into three groups: MetS, exenatide-treated (5 mu g/kg), dulaglutide-treated (0.6 mg/kg). After 6 weeks of treatment, in vivo heart function was assessed via echocardiography, while ex vivo function was evaluated using a Langendorff apparatus to simulate ischemia-reperfusion injury. Heart tissue samples were analyzed histologically, and oxidative stress biomarkers were measured spectrophotometrically from the coronary venous effluent. Both exenatide and dulaglutide significantly improved the ejection fraction by 3% and 7%, respectively, compared to the MetS group. Histological analyses corroborated these findings, revealing a reduction in the cross-sectional area of cardiomyocytes by 11% in the exenatide and 18% in the dulaglutide group, indicating reduced myocardial damage in GLP-1RA-treated rats. Our findings suggest strong cardioprotective potential of GLP-1RAs in MetS, with dulaglutide showing a slight advantage. Thus, both exenatide and dulaglutide are potentially promising targets for cardioprotection and reducing mortality in MetS patients.
C1 [Ravic, Marko; Novakovic, Jovana; Andjic, Marijana; Stojanovic, Aleksandra] Univ Kragujevac, Fac Med Sci, Dept Pharm, Svetozara Markov 69, Kragujevac 34000, Serbia.
   [Ravic, Marko; Srejovic, Ivan; Novakovic, Jovana; Andjic, Marijana; Sretenovic, Jasmina; Muric, Maja; Nikolic, Marina; Stojanovic, Aleksandra; Jakovljevic, Vladimir] Univ Kragujevac, Ctr Excellence Study Redox Balance Cardiovasc & Me, Svetozara Markov 69, Kragujevac 34000, Serbia.
   [Srejovic, Ivan; Sretenovic, Jasmina; Muric, Maja; Nikolic, Marina; Jakovljevic, Vladimir] Univ Kragujevac, Fac Med Sci, Dept Physiol, Svetozara Markov 69, Kragujevac 34000, Serbia.
   [Srejovic, Ivan; Kasabov, Kirill Alekseevich; Fisenko, Vladimir Petrovich] First Moscow State Med Univ IM Sechenov, Dept Pharmacol, Trubetskaya St 8,Str 2, Moscow 119991, Russia.
   [Bolevich, Sergey; Jakovljevic, Vladimir] First Moscow State Med Univ IM Sechenov, Dept Human Pathol, Trubetskaya St 8,Str 2, Moscow 119991, Russia.
C3 University of Kragujevac; University of Kragujevac; University of
   Kragujevac; Sechenov First Moscow State Medical University; Sechenov
   First Moscow State Medical University
RP Stojanovic, A (corresponding author), Univ Kragujevac, Fac Med Sci, Dept Pharm, Svetozara Markov 69, Kragujevac 34000, Serbia.; Stojanovic, A (corresponding author), Univ Kragujevac, Ctr Excellence Study Redox Balance Cardiovasc & Me, Svetozara Markov 69, Kragujevac 34000, Serbia.
EM markoravic@hotmail.com; ivan_srejovic@hotmail.com;
   jovana.ilona@gmail.com; andjicmarijana10@gmail.com;
   drj.sretenovic@gmail.com; majanikolickg90@gmail.com;
   marina.rankovic.95@gmail.com; bolevich2011@yandex.ru;
   kasabov_k_a@staff.sechenov.ru; fisenko_v_p@staff.sechenov.ru;
   vranicaleksandra90@gmail.com; drvladakgbg@yahoo.com
RI Srejovic, Ivan/L-2468-2019; Vranic, Aleksandra/AAZ-2715-2020;
   Jakovljevic, Vladimir/V-1583-2019; Sretenovic, Jasmina/AAS-2203-2021
OI Sretenovic, Jasmina/0000-0001-5849-1998; Ravic,
   Marko/0000-0002-7436-1242; Novakovic, Jovana/0000-0002-8084-3264;
   Stojanovic, Aleksandra/0000-0002-6429-7953; Srejovic,
   Ivan/0000-0002-3835-1856; Nikolic, Marina/0000-0001-7829-5812
FU Faculty of Medical Sciences, University of Kragujevac
FX No Statement Available
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NR 73
TC 1
Z9 1
U1 1
U2 11
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1424-8247
J9 PHARMACEUTICALS-BASE
JI Pharmaceuticals
PD APR
PY 2024
VL 17
IS 4
AR 525
DI 10.3390/ph17040525
PG 19
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA OV0I6
UT WOS:001209933800001
PM 38675485
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Barona, J
   Blesso, CN
   Andersen, CJ
   Park, Y
   Lee, J
   Fernandez, ML
AF Barona, Jacqueline
   Blesso, Christopher N.
   Andersen, Catherine J.
   Park, Youngki
   Lee, Jiyoung
   Fernandez, Maria Luz
TI Grape Consumption Increases Anti-Inflammatory Markers and Upregulates
   Peripheral Nitric Oxide Synthase in the Absence of Dyslipidemias in Men
   with Metabolic Syndrome
SO NUTRIENTS
LA English
DT Article
DE metabolic syndrome; dyslipidemia; grape polyphenols; IL-10; iNOS
ID OXIDATIVE STRESS; INTERLEUKIN-10 LEVELS; GENE-EXPRESSION; NADPH OXIDASE;
   RED WINE; POLYPHENOLS; ATHEROSCLEROSIS; ADIPONECTIN; CELLS; JUICE
AB We evaluated the effects of grape consumption on inflammation and oxidation in the presence or absence of dyslipidemias in metabolic syndrome (MetS). Men with MetS (n = 24), 11 with high triglycerides and low HDL and 13 with no dyslipidemia were recruited and randomly allocated to consume daily either 46 g of lyophilized grape powder (GRAPE), equivalent to 252 g fresh grapes, or placebo with an identical macronutrient composition and caloric value as GRAPE for four weeks. After a three-week washout, participants followed the alternate treatment. We measured changes between placebo and GRAPE periods in inflammatory and oxidative stress markers both in circulation and in gene expression. Changes in plasma adiponectin (p < 0.05), interleukin (IL)-10 (p < 0.005) and in mRNA expression of the inducible isoform of nitric oxide synthase (iNOS) (p < 0.25) were increased in the GRAPE compared to the placebo period only in those individuals without dyslipidemia. Additionally, plasma IL-10 was negatively correlated with NOX2 expression, a marker of oxidative stress (r = -0.55, p < 0.01), while iNOS expression was positively correlated with the expression of superoxide dismutase 2 (r = 0.642, p < 0.01), a key anti-oxidative enzyme. Grape consumption displayed anti-oxidative and increased anti-inflammatory markers in the absence of the inflammatory milieu associated with dyslipidemias.
C1 [Barona, Jacqueline; Blesso, Christopher N.; Andersen, Catherine J.; Park, Youngki; Lee, Jiyoung; Fernandez, Maria Luz] Univ Connecticut, Dept Nutr Sci, Storrs, CT 06269 USA.
   [Barona, Jacqueline] Univ Antioquia, Sch Microbiol, Medellin 1226, Colombia.
C3 University of Connecticut; Universidad de Antioquia
RP Fernandez, ML (corresponding author), Univ Connecticut, Dept Nutr Sci, Storrs, CT 06269 USA.
EM jacqbar@yahoo.com; cblesso@gmail.com; catherine.andersen@uconn.edu;
   young-ki.park@uconn.edu; ji-young.lee@uconn.edu;
   maria-luz.fernandez@uconn.edu
RI Blesso, Christopher/N-9495-2014; Acevedo, Maria/A-8759-2019
OI Andersen, Catherine/0000-0001-9774-5030; Fernandez,
   Maria-Luz/0000-0002-1835-0792; Barona Acevedo, Maria
   Jacqueline/0000-0002-0592-9324
FU California Table Grape Commission
FX MLF received funding from the California Table Grape Commission to
   conduct this study. JB, CNB, CJA, KJP and JYL declare no conflicts of
   interest.
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NR 34
TC 42
Z9 47
U1 0
U2 14
PU MDPI AG
PI BASEL
PA POSTFACH, CH-4005 BASEL, SWITZERLAND
SN 2072-6643
J9 NUTRIENTS
JI Nutrients
PD DEC
PY 2012
VL 4
IS 12
BP 1945
EP 1957
DI 10.3390/nu4121945
PG 13
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 060KO
UT WOS:000312776900008
PM 23222963
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Kelany, ME
   Hakami, TM
   Omar, AH
AF Kelany, Mohamed Elsayed
   Hakami, Tahir M.
   Omar, Adel H.
TI Curcumin improves the metabolic syndrome in high-fructose-diet-fed rats:
   role of TNF-α, NF-κB, and oxidative stress
SO CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
LA English
DT Article
DE curcumin; fructose; metabolic syndrome; insulin resistance; rats
ID INSULIN-RESISTANCE; ACTIVATION; HYPERTENSION; HOMEOSTASIS; PREVENTION;
   EFFICACY; TISSUES; PATHWAY; OBESITY; WEIGHT
AB This study aimed to investigate effects of curcumin on high fructose diet (HFD)-induced metabolic syndrome (MetS) in rats and the possible mechanisms involved. MetS was induced in male albino rats (n = 20), over 8 weeks, by 65% HFD. For 8-week experiment period, rats were assigned to 2 equal groups: curcumin-treated rats received curcumin (200 mg/kg, p.o, once daily) along with HFD, and untreated rats were fed with HFD only. We evaluated body mass (BM), systolic blood pressure (SBP), homeostasis model assessment of insulin resistance (HOMA-IR), and serum levels of glucose, insulin, leptin, total cholesterol (TC), triglycerides (TGs), uric acid, malondialdehyde (MDA; lipid peroxidation product), and tumor necrosis factor-alpha (TNF-alpha; inflammatory cytokine), and serum catalase (endogenous antioxidant) activity and immunohistochemical expression of nuclear factor kappa B (NF-kappa B; inflammation-related transcription factor) in hepatocytes. HFD produced increases in BM, SBP, HOMA-IR, and serum levels of glucose, insulin, leptin, TC, TGs, uric acid, MDA, and TNF-alpha, a decrease in catalase activity, and strong positive expression of NF-kappa B in hepatocytes. Curcumin, in presence of HFD, produced significant improvements in all glucose and fat metabolism parameters, and in oxidative stress and inflammation biomarkers. Curcumin may potentially be useful in the treatment of MetS through its ability to modulate oxidation stress status and inflammation cascades.
C1 [Kelany, Mohamed Elsayed] Zagazig Univ, Fac Med, Dept Clin Pharmacol, Zagazig, Egypt.
   [Hakami, Tahir M.] Jazan Univ, Fac Med, Dept Clin Pharmacol, Jizan, Saudi Arabia.
   [Omar, Adel H.] Menoufeya Univ, Fac Med, Dept Clin Pharmacol, Shibin Al Kawm, Egypt.
C3 Egyptian Knowledge Bank (EKB); Zagazig University; Jazan University;
   Egyptian Knowledge Bank (EKB); Menofia University
RP Kelany, ME (corresponding author), Zagazig Univ, Fac Med, Dept Clin Pharmacol, Zagazig, Egypt.
EM drmkelany@hotmail.com
RI Hakami, Tahir/GVT-1058-2022
OI Hakami, Tahir/0000-0002-1933-6044
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NR 50
TC 49
Z9 54
U1 1
U2 20
PU CANADIAN SCIENCE PUBLISHING
PI OTTAWA
PA 65 AURIGA DR, SUITE 203, OTTAWA, ON K2E 7W6, CANADA
SN 0008-4212
EI 1205-7541
J9 CAN J PHYSIOL PHARM
JI Can. J. Physiol. Pharmacol.
PD FEB
PY 2017
VL 95
IS 2
BP 140
EP 150
DI 10.1139/cjpp-2016-0152
PG 11
WC Pharmacology & Pharmacy; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Physiology
GA EM6KK
UT WOS:000395421200005
PM 27901349
DA 2025-06-11
ER

PT J
AU Darvall, KAL
   Sam, RC
   Silverman, SH
   Bradbury, AW
   Adam, DJ
AF Darvall, K. A. L.
   Sam, R. C.
   Silverman, S. H.
   Bradbury, A. W.
   Adam, D. J.
TI Obesity and thrombosis
SO EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
LA English
DT Review
DE obesity; thrombosis; leptin; adiponectin; venous thromboembolism;
   metabolic syndrome
ID C-REACTIVE PROTEIN; BODY-MASS INDEX; PLASMINOGEN-ACTIVATOR INHIBITOR;
   CARDIOVASCULAR RISK-FACTORS; PERIPHERAL ARTERIAL-DISEASE; LIFE-STYLE
   MODIFICATION; CORONARY-HEART-DISEASE; VON-WILLEBRAND-FACTOR; METABOLIC
   SYNDROME; OXIDATIVE STRESS
AB Objectives. To describe the pathophysiological mechanisms by which obesity increases the propensity to thrombosis, the leading cause of death in the Western World, with particular emphasis on the role of inflammation, oxidative stress, dyslipidaemia, insulin resistance and the coagulation cascade.
   Design. Review article.
   Materials and methods. Medline (1966-2005) and Cochrane library review of literature examining the relationship between obesity and thrombosis. Search terms included obesity, overweight, body mass index, thrombosis, cardiovascular disease, venous thromboembolism, peripheral arterial disease, and coronary heart disease.
   Results. Obesity is an important and growing public health issue that is estimated to affect more than half of the UK adult population. Obesity, in particular central (visceral) obesity, is associated with significant, and largely preventable, morbidity and mortality including an increased incidence and prevalence of arterial and venous thrombotic events. The various mechanisms by which obesity may cause thrombosis include: the actions of so-called adipocytokines from adipose tissue, e.g. leptin and adiponectin; increased activity of the coagulation cascade and decreased activity of the fibrinolytic cascade; increased inflammation; increased oxidative stress and endothelial dysfunction; and disturbances of lipids and glucose tolerance in association with the metabolic syndrome.
   Conclusions. Obesity appears to be associated with thrombosis via several mechanisms. These pro-thrombotic factors are all improved by weight loss.
C1 City Hosp, Dept Vasc Surg, Birmingham, W Midlands, England.
   Univ Birmingham, Heartlands Hosp, Dept Vasc Surg, Birmingham B15 2TT, W Midlands, England.
C3 University of Birmingham; University of Birmingham; Heart of England NHS
   Foundation Trust; Heartlands Hospital
RP Darvall, KAL (corresponding author), Univ Birmingham, Solihull Hosp, Flat 5 Netherwood House,Lode Lane, Solihull, W Midlands, England.
EM katydarvall@btinternet.com
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NR 97
TC 248
Z9 265
U1 0
U2 16
PU W B SAUNDERS CO LTD
PI LONDON
PA 32 JAMESTOWN RD, LONDON NW1 7BY, ENGLAND
SN 1078-5884
EI 1532-2165
J9 EUR J VASC ENDOVASC
JI Eur. J. Vasc. Endovasc. Surg.
PD FEB
PY 2007
VL 33
IS 2
BP 223
EP 233
DI 10.1016/j.ejvs.2006.10.006
PG 11
WC Surgery; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery; Cardiovascular System & Cardiology
GA 136TR
UT WOS:000244247500017
PM 17185009
OA Bronze
DA 2025-06-11
ER

PT J
AU Fernández-Aparicio, A
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AF Fernandez-Aparicio, Angel
   Schmidt-RioValle, Jacqueline
   Perona, Javier S.
   Correa-Rodriguez, Maria
   Castellano, Jose M.
   Gonzalez-Jimenez, Emilio
TI Potential Protective Effect of Oleanolic Acid on the Components of
   Metabolic Syndrome: A Systematic Review
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Review
DE triterpenes; metabolic syndrome; insulin resistance; hypertension;
   inflammation; obesity
ID OXIDATIVE STRESS; HIGH-FAT; INSULIN-RESISTANCE; FRUCTOSE; OBESITY;
   MODULATION; PRESSURE; INCREASE
AB The high prevalence of obesity is a serious public health problem in today's world. Both obesity and insulin resistance favor the development of metabolic syndrome (MetS), which is associated with a number of pathologies, especially type 2 diabetes mellitus, and cardiovascular diseases. This serious problem highlights the need to search for new natural compounds to be employed in therapeutic and preventive strategies, such as oleanolic acid (OA). This research aimed to systematically review the effects of OA on the main components of MetS as well as oxidative stress in clinical trials and experimental animal studies. Databases searched included PubMed, Medline, Web of Science, Scopus, EMBASE, Cochrane, and CINAHL from 2013 to 2019. Thus, both animal studies (n = 23) and human clinical trials (n = 1) were included in our review to assess the effects of OA formulations on parameters concerning insulin resistance and the MetS components. The methodological quality assessment was performed through using the SYRCLE's Risk of Bias for animal studies and the Jadad scale. According to the studies in our review, OA improves blood pressure levels, hypertriglyceridemia, hyperglycemia, oxidative stress, and insulin resistance. Although there is scientific evidence that OA has beneficial effects in the prevention and treatment of MetS and insulin resistance, more experimental studies and randomized clinical trials are needed to guarantee its effectiveness.
C1 [Fernandez-Aparicio, Angel; Schmidt-RioValle, Jacqueline; Correa-Rodriguez, Maria; Gonzalez-Jimenez, Emilio] Univ Granada, Fac Hlth Sci, Dept Nursing, Av Ilustrac 60, Granada 18016, Spain.
   [Perona, Javier S.; Castellano, Jose M.] CSIC, Spanish Natl Res Council, Inst Grasa, Campus Univ Pablo de Olavide, Seville 41013, Spain.
C3 University of Granada; Consejo Superior de Investigaciones Cientificas
   (CSIC); CSIC - Instituto de la Grasa (IG)
RP Schmidt-RioValle, J (corresponding author), Univ Granada, Fac Hlth Sci, Dept Nursing, Av Ilustrac 60, Granada 18016, Spain.
EM jschmidt@ugr.es
RI Perona, J/B-9721-2014; Gonzalez-Jimenez, Emilio/I-6039-2017; Castellano
   Orozco, Jose Maria/L-6220-2014; Fernandez-Aparicio, Angel/K-8130-2017;
   Correa-Rodriguez, Maria/G-1793-2018; Schmidt-Riovalle,
   Jacqueline/I-6333-2017
OI Gonzalez-Jimenez, Emilio/0000-0001-5103-6028; Castellano Orozco, Jose
   Maria/0000-0003-3051-3264; Fernandez-Aparicio,
   Angel/0000-0002-1298-8349; Correa-Rodriguez, Maria/0000-0001-9165-4349;
   Schmidt-Riovalle, Jacqueline/0000-0003-2775-0058
FU University of Granada, Spain [B 12.56.1]; University of Granada, Spain
FX The results reported in the study are from the doctoral thesis of the
   main author and belong to the Clinical Medicine and Health Public
   Programme (B 12.56.1) of the University of Granada, Spain. F.-A. A is
   granted with a pre-doctoral FPU grant (University of Granada, Spain).
   This work was also supported by a research initiation fellowship of the
   University of Granada, Spain.
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NR 64
TC 18
Z9 18
U1 0
U2 21
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD SEP
PY 2019
VL 8
IS 9
AR 1294
DI 10.3390/jcm8091294
PG 16
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA JC3NA
UT WOS:000489184200028
PM 31450844
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Li, ZL
   Woollard, JR
   Ebrahimi, B
   Crane, JA
   Jordan, KL
   Lerman, A
   Wang, SM
   Lerman, LO
AF Li, Zi-Lun
   Woollard, John R.
   Ebrahimi, Behzad
   Crane, John A.
   Jordan, Kyra L.
   Lerman, Amir
   Wang, Shen-Ming
   Lerman, Lilach O.
TI Transition From Obesity to Metabolic Syndrome Is Associated With Altered
   Myocardial Autophagy and Apoptosis
SO ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
LA English
DT Article
DE obesity; autophagy; cardiac function; inflammation; metabolic-syndrome
ID INSULIN-RESISTANCE; DOWN-REGULATION; EXPERIMENTAL HYPERCHOLESTEROLEMIA;
   CARDIOVASCULAR-DISEASE; DIASTOLIC DYSFUNCTION; OXIDATIVE STRESS; ER
   STRESS; MECHANISMS; HEART; SWINE
AB Objective-Transition from obesity to metabolic-syndrome (MetS) promotes cardiovascular diseases, but the underlying cardiac pathophysiological mechanisms are incompletely understood. We tested the hypothesis that development of insulin resistance and MetS is associated with impaired myocardial cellular turnover.
   Methods and Results-MetS-prone Ossabaw pigs were randomized to 10 weeks of standard chow (lean) or to 10 (obese) or 14 (MetS) weeks of atherogenic diet (n=6 each). Cardiac structure, function, and myocardial oxygenation were assessed by multidetector computed-tomography and Blood Oxygen Level-Dependent-MRI, the microcirculation with microcomputed-tomography, and injury mechanisms by immunoblotting and histology. Both obese and MetS showed obesity and dyslipidemia, whereas only MetS showed insulin resistance. Cardiac output and myocardial perfusion increased only in MetS, yet Blood Oxygen Level-Dependent-MRI showed hypoxia. Inflammation, oxidative stress, mitochondrial dysfunction, and fibrosis also increased in both obese and MetS, but more pronouncedly in MetS. Furthermore, autophagy in MetS was decreased and accompanied by marked apoptosis.
   Conclusion-Development of insulin resistance characterizing a transition from obesity to MetS is associated with progressive changes of myocardial autophagy, apoptosis, inflammation, mitochondrial dysfunction, and fibrosis. Restoring myocardial cellular turnover may represent a novel therapeutic target for preserving myocardial structure and function in obesity and MetS. (Arterioscler Thromb Vasc Biol. 2012; 32: 1132-1141.)
C1 [Li, Zi-Lun; Woollard, John R.; Ebrahimi, Behzad; Crane, John A.; Jordan, Kyra L.; Lerman, Lilach O.] Mayo Clin, Div Nephrol & Hypertens, Rochester, MN 55905 USA.
   [Li, Zi-Lun; Wang, Shen-Ming] Sun Yat Sen Univ, Affiliated Hosp 1, Div Vasc Surg, Guangzhou 510275, Guangdong, Peoples R China.
   [Lerman, Amir; Lerman, Lilach O.] Mayo Clin, Div Cardiovasc Dis, Rochester, MN 55905 USA.
C3 Mayo Clinic; Sun Yat Sen University; Mayo Clinic
RP Lerman, LO (corresponding author), Mayo Clin, Div Nephrol & Hypertens, 200 1st St SW, Rochester, MN 55905 USA.
EM lerman.lilach@mayo.edu
RI Lerman, Lilach/M-4962-2017
OI Ebrahimi, Behzad/0000-0001-6907-7696
FU NIH [DK73608, HL77131, HL085307, C06-RR018898]; China Scholarship
   Council under the authority of the Ministry of Education of the People's
   Republic of China
FX This study was partly supported by NIH grants numbers DK73608, HL77131,
   HL085307, and C06-RR018898. Zilun Li is supported by the China
   Scholarship Council under the authority of the Ministry of Education of
   the People's Republic of China.
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NR 53
TC 88
Z9 97
U1 2
U2 21
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1079-5642
EI 1524-4636
J9 ARTERIOSCL THROM VAS
JI Arterioscler. Thromb. Vasc. Biol.
PD MAY
PY 2012
VL 32
IS 5
BP 1132
EP +
DI 10.1161/ATVBAHA.111.244061
PG 18
WC Hematology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Hematology; Cardiovascular System & Cardiology
GA 931DL
UT WOS:000303195100017
PM 22383702
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Oltman, CL
   Kleinschmidt, TL
   Davidson, EP
   Coppey, LJ
   Lund, DD
   Yorek, MA
AF Oltman, Christine L.
   Kleinschmidt, Travis L.
   Davidson, Eric P.
   Coppey, Lawrence J.
   Lund, Donald D.
   Yorek, Mark A.
TI Treatment of cardiovascular dysfunction associated with the metabolic
   syndrome and type 2 diabetes
SO VASCULAR PHARMACOLOGY
LA English
DT Article
DE ACE inhibitors; acetylcholine; statins; diabetes; coronary circulation;
   endothelial function
ID NITRIC-OXIDE SYNTHASE; ZUCKER OBESE RATS; NAD(P)H OXIDASE; CORONARY;
   STRESS; VASODILATION; PROGRESSION; ARTERIOLES; REACTIVITY; DILATION
AB Our previous studies have shown vascular dysfunction in small coronary and mesenteric arteries in Zucker obese rats, a model of the metabolic syndrome, and Zucker Diabetic Fatty (ZDF) rats, a model of type 2 diabetes. Because of their lipid lowering action and antioxidant activity, we predicted that treatment with Rosuvastatin, an HMG-CoA reductase inhibitor (statin) or Enalapril, an angiotensin converting enzyme (ACE) inhibitor would improve vascular dysfunction associated with the metabolic syndrome and type 2 diabetes.
   Methods: 20-week-old Zucker obese and 16-week-old ZDF rats were treated with Rosuvastatin (25 mg/kg/day) or Enalapril (20 mg/kg/day) for 12 weeks. We examined metabolic parameters, indices of oxidative stress and vascular dysfunction in ventricular and mesenteric small arteries (75-175 mu m intraluminal diameter) from lean, Zucker obese and ZDF rats (untreated and treated).
   Results: Endothelial dependent responses were attenuated in coronary vessels from Zucker obese and ZDF rats compared to responses from lean rats. Both drugs improved metabolic parameters, oxidative stress, and vascular dysfunction in Zucker obese rats, however, only partial improvement was observed in ZDF rats, suggesting more aggressive treatment is needed when hyperglycemia is involved.
   Conclusion: Vascular dysfunction is improved when Zucker obese and, to a lesser degree, when ZDF rats were treated with Rosuvastatin or Enalapril. Published by Elsevier Inc.
C1 [Oltman, Christine L.] Univ Iowa, VA Med Ctr, Dept Vet Affairs, Iowa City, IA 52246 USA.
   Univ Iowa, Coll Med, Dept Internal Med, Iowa City, IA 52242 USA.
C3 University of Iowa; US Department of Veterans Affairs; Veterans Health
   Administration (VHA); Iowa City VA Health Care System; University of
   Iowa
RP Oltman, CL (corresponding author), Univ Iowa, VA Med Ctr, Dept Vet Affairs, Highway 6 W, Iowa City, IA 52246 USA.
EM christine-oltman@uiowa.edu
RI Yorek, Mark/AAC-3136-2021
OI Yorek, Mark/0000-0001-7737-5554
FU NIDDK NIH HHS [DK073990, R56 DK073990] Funding Source: Medline
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NR 29
TC 18
Z9 20
U1 0
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1537-1891
EI 1879-3649
J9 VASC PHARMACOL
JI Vasc. Pharmacol.
PD JAN
PY 2008
VL 48
IS 1
BP 47
EP 53
DI 10.1016/j.vph.2007.11.005
PG 7
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 261EJ
UT WOS:000253061600007
PM 18164667
DA 2025-06-11
ER

PT J
AU Beach, SRH
   Lei, MK
   Simons, RL
   Barr, AB
   Simons, LG
   Ehrlich, K
   Brody, GH
   Philibert, RA
AF Beach, Steven R. H.
   Lei, Man Kit
   Simons, Ronald L.
   Barr, Ashley B.
   Simons, Leslie G.
   Ehrlich, Katherine
   Brody, Gene H.
   Philibert, Robert A.
TI When inflammation and depression go together: The longitudinal effects
   of parent-child relationships
SO DEVELOPMENT AND PSYCHOPATHOLOGY
LA English
DT Article
ID ADULT ROMANTIC RELATIONSHIPS; RACIAL-DISCRIMINATION;
   SOCIOECONOMIC-STATUS; ECONOMIC HARDSHIP; PERCEIVED DISCRIMINATION;
   HEALTH EXPLORATION; METABOLIC SYNDROME; STRESS; ASSOCIATIONS; ADVERSITY
AB Parent-child relationships have long-term effects on health, particularly later inflammation and depression. We hypothesized that these effects would be mediated by later romantic partner relationships and elevated stressors in young adulthood, helping promote chronic, low grade, inflammation as well as depressive symptoms, and driving their covariation. It has been proposed recently that youth experiencing harsher parenting may also develop a stronger association between inflammation and depressive symptoms in adulthood and altered effects of stressors on outcomes. In the current investigation, we test these ideas using an 18-year longitudinal study of N = 413 African American youth that provides assessment of the parent-child relationship (at age 10), pro-inflammatory cytokine profile and depressive symptoms (at age 28), and potential mediators in early young adulthood (assessed at ages 21 and 24). As predicted, the effect of harsher parent-child relationships (age 10) on pro-inflammatory state and increased depressive symptoms at age 28 were fully mediated through young adult stress and romantic partner relationships. In addition, beyond these mediated effects, parent-child relationships at age 10 moderated the concurrent association between inflammation and depressive symptoms, as well as the prospective association between romantic partner relationships and inflammation, and resulted in substantially different patterns of indirect effects from young adult mediators to outcomes. The results support theorizing that the association of depression and inflammation in young adulthood is conditional on earlier parenting, and suggest incorporating this perspective into models predicting long-term health outcomes.
C1 [Beach, Steven R. H.; Lei, Man Kit; Simons, Ronald L.; Simons, Leslie G.; Ehrlich, Katherine; Brody, Gene H.] Univ Georgia, Athens, GA 30602 USA.
   [Barr, Ashley B.] SUNY Buffalo, Buffalo, NY USA.
   [Philibert, Robert A.] Univ Iowa, Iowa City, IA USA.
C3 University System of Georgia; University of Georgia; State University of
   New York (SUNY) System; University at Buffalo, SUNY; University of Iowa
RP Beach, SRH (corresponding author), Univ Georgia, Ctr Family Res, 1095 Coll Stn Rd, Athens, GA 30602 USA.
EM srhbeach@uga.edu
RI Barr, Ashley/KXR-8182-2024; Lei, Man/AAM-9616-2020; Ehrlich,
   Katherine/AAF-4687-2020; Beach, Steven/MBH-1541-2025
OI Lei, Man-Kit/0000-0002-7757-6548; Philibert, Robert/0000-0001-7822-4977
FU National Heart, Lung, and Blood Institute [R01 HL8045]; National
   Institute of Child Health and Human Development [R01 HD080749]; National
   Institute on Drug Abuse [P30 DA027827]
FX This research was supported by Award Number R01 HL8045 from the National
   Heart, Lung, and Blood Institute; Award Number R01 HD080749 from the
   National Institute of Child Health and Human Development; and P30
   DA027827 from the National Institute on Drug Abuse. The content is
   solely the responsibility of the authors and does not necessarily
   reflect the official views of the National Institutes of Health or any
   agencies that comprise it.
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NR 88
TC 18
Z9 24
U1 0
U2 22
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
SN 0954-5794
EI 1469-2198
J9 DEV PSYCHOPATHOL
JI Dev. Psychopathol.
PD DEC
PY 2017
VL 29
IS 5
SI SI
BP 1969
EP 1986
DI 10.1017/S0954579417001523
PG 18
WC Psychology, Developmental
WE Social Science Citation Index (SSCI)
SC Psychology
GA FX3EF
UT WOS:000425952800032
PM 29162196
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Sironi, M
   Ploubidis, GB
   Grundy, EM
AF Sironi, Maria
   Ploubidis, George B.
   Grundy, Emily M.
TI Fertility History and Biomarkers Using Prospective Data: Evidence From
   the 1958 National Child Development Study
SO DEMOGRAPHY
LA English
DT Article
DE Biomarkers; Fertility; Parity; Age at childbearing; Health
ID LATER-LIFE HEALTH; CAUSE-SPECIFIC MORTALITY; CORONARY-HEART-DISEASE;
   REPRODUCTIVE HISTORY; MENTAL-HEALTH; RISK-FACTORS; MIDLIFE MORTALITY;
   TEEN CHILDBEARING; YOUNG FATHERHOOD; WOMENS HEALTH
AB Research on the later-life health implications of fertility history has predominantly considered associations with mortality or self-reported indicators of health. Most of this previous research has either not been able to account for selection factors related to both early-life and later-life health or has had to rely on retrospectively reported accounts of childhood circumstances. Using the 1958 National Child Development Study, and in particular the biomedical survey conducted in 2002-2003, we investigate associations between fertility histories (number of children and age at first and at last birth) and biomarkers for cardiometabolic risk and respiratory function in midlife among both men and women. Results from models that adjusted for a very wide range of childhood factors, including early-life socioeconomic position, cognitive ability, and mental health, showed weak associations between parity and biomarkers. However, we found an inverse association between age at first birth and biomarkers indicative of worse cardiometabolic health, with poorer outcomes for those with very young ages at entry to parenthood and increasingly better outcomes for those becoming parents at older ages. A very young age at last birth was also associated with less favorable biomarker levels, especially among women. Results highlight the value of prospectively collected data and the availability of biomarkers in studies of life course determinants of health in midlife and later.
C1 [Sironi, Maria; Ploubidis, George B.] UCL, Dept Social Sci, 55-59 Gordon Sq, London WC1H 0NU, England.
   [Ploubidis, George B.] UCL, UCL Ctr Longitudinal Studies, 55-59 Gordon Sq, London WC1H 0NU, England.
   [Grundy, Emily M.] Univ Essex, Inst Social & Econ Res, Wivenhoe Pk, Colchester CO4 3SQ, Essex, England.
   [Grundy, Emily M.] Norwegian Inst Publ Hlth, Ctr Fertil & Hlth, Lovisenberggata 8, N-0456 Oslo, Norway.
C3 University of London; University College London; University of London;
   University College London; University of Essex; Norwegian Institute of
   Public Health (NIPH)
RP Sironi, M (corresponding author), UCL, Dept Social Sci, 55-59 Gordon Sq, London WC1H 0NU, England.
EM m.sironi@ucl.ac.uk; g.ploubidis@ucl.ac.uk; emily.grundy@essex.ac.uk
RI Ploubidis, George/G-9531-2011; Grundy, Emily/AAC-3260-2019
OI Sironi, Maria/0000-0002-8005-7255; Grundy, Emily/0000-0002-9633-1116
FU British Academy [169934]; Norwegian Research Council under the Centre of
   Excellence funding scheme [262700]; ESRC [ES/S012486/1, ES/M001660/1]
   Funding Source: UKRI; MRC [MR/P023444/1] Funding Source: UKRI
FX This study was funded by the British Academy (Grant No. 169934) and
   Norwegian Research Council under the Centre of Excellence funding scheme
   (Grant No. 262700).
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   Williams K, 2011, AM SOCIOL REV, V76, P465, DOI 10.1177/0003122411409705
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NR 73
TC 16
Z9 16
U1 1
U2 5
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0070-3370
EI 1533-7790
J9 DEMOGRAPHY
JI Demography
PD APR
PY 2020
VL 57
IS 2
BP 529
EP 558
DI 10.1007/s13524-020-00855-x
EA MAR 2020
PG 30
WC Demography
WE Social Science Citation Index (SSCI)
SC Demography
GA LD9KM
UT WOS:000521776300001
PM 32133595
OA Green Published, hybrid, Green Accepted
DA 2025-06-11
ER

PT J
AU Hussain, M
   Johnson, AE
   Hua, J
   Hinojosa, BM
   Zawadzki, MJ
   Howell, JL
AF Hussain, Maryam
   Johnson, Angela E.
   Hua, Jacqueline
   Hinojosa, Bianca M.
   Zawadzki, Matthew J.
   Howell, Jennifer L.
TI When belongingness backfires: experienced discrimination predicts
   increased cardiometabolic risk among college students high in social
   belonging
SO JOURNAL OF BEHAVIORAL MEDICINE
LA English
DT Article
DE Cardiometabolic disease risk; College students; Discrimination; Social
   belonging
ID RACIAL-DISCRIMINATION; AFRICAN-AMERICAN; MENTAL-HEALTH; SENSE;
   HYPERTENSION; PREVALENCE; TRANSITION; UNIVERSITY; INCLUSION; EXCLUSION
AB Research implicates experiences of discrimination in exacerbating cardiometabolic disease (CMD) risk. Belongingness has been suggested as a buffer against the adverse effects of discrimination. However, when discrimination occurs in an environment to which one feels they belong, then the potential benefits of belongingness may dissipate or even exacerbate the effects of discrimination. In the present study, we examined these competing hypotheses on how campus belonging might moderate the relationship between discrimination experienced on campus and CMD risk. College students (n = 160, 60.9% Latino/a/x) reported the frequency of on-campus discrimination and campus belongingness, and then completed items assessing risk for CMD. More frequent discrimination related to higher comparative CMD risk among those who reported high campus belongingness, even after adjusting for relevant covariates. These findings highlight the complicated nature of belongingness in the context of physical health. Future research is needed to better understand the role of environment when considering morbidity among college students.
C1 [Hussain, Maryam; Johnson, Angela E.; Hua, Jacqueline; Hinojosa, Bianca M.; Zawadzki, Matthew J.; Howell, Jennifer L.] Univ Calif, Dept Psychol Sci, 5200 Lake Rd, Merced, CA 95343 USA.
C3 University of California System; University of California Merced
RP Hussain, M (corresponding author), Univ Calif, Dept Psychol Sci, 5200 Lake Rd, Merced, CA 95343 USA.
EM mhussain5@ucmerced.edu
RI Howell, Jennifer/AAS-4791-2020
OI Howell, Jennifer/0000-0001-5418-3736; Hinojosa,
   Bianca/0000-0001-6087-7195
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NR 48
TC 3
Z9 3
U1 0
U2 7
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0160-7715
EI 1573-3521
J9 J BEHAV MED
JI J. Behav. Med.
PD AUG
PY 2021
VL 44
IS 4
SI SI
BP 571
EP 578
DI 10.1007/s10865-021-00228-8
EA APR 2021
PG 8
WC Psychology, Clinical
WE Social Science Citation Index (SSCI)
SC Psychology
GA TV5BJ
UT WOS:000644876100001
PM 33905032
DA 2025-06-11
ER

PT J
AU Gómez-Viquez, NL
   Balderas-Villalobos, J
   Bello-Sánchez, MD
   Mayorga-Luna, M
   Mailloux-Salinas, P
   García-Castañeda, M
   Rios-Perez, EB
   Mártinez-Avila, MA
   Camacho-Castillo, LD
   Bravo, G
   Avila, G
   Altamirano, J
   Carvajal, K
AF Leticia Gomez-Viquez, Norma
   Balderas-Villalobos, Jaime
   Dolores Bello-Sanchez, Ma
   Mayorga-Luna, Maritza
   Mailloux-Salinas, Patrick
   Garcia-Castaneda, Maricela
   Benjamin Rios-Perez, Erick
   Antonio Martinez-Avila, Marco
   del Carmen Camacho-Castillo, Luz
   Bravo, Guadalupe
   Avila, Guillermo
   Altamirano, Julio
   Carvajal, Karla
TI Oxidative stress in early metabolic syndrome impairs cardiac RyR2 and
   SERCA2a activity and modifies the interplay of these proteins during
   Ca<SUP>2+</SUP> waves
SO ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
LA English
DT Article
DE Cardiac metabolic syndrome; ryanodine receptors (RyR2); L-type
   Ca2+channels (LCC); sarco; endoplasmic reticulum Ca2+ATPase 2a
   (SERCA2a); reactive oxygen species
ID RYANODINE RECEPTORS CONTRIBUTES; INSULIN-RESISTANCE ROLE;
   SARCOPLASMIC-RETICULUM; S-NITROSYLATION; CALCIUM WAVES; CONTRACTILE
   DYSFUNCTION; REDOX MODIFICATION; HEART; MYOCYTES; CHANNELS
AB We investigated how oxidative stress (OS) alters Ca2+ handling in ventricular myocytes in early metabolic syndrome (MetS) in sucrose-fed rats. The effects of N-acetyl cysteine (NAC) or dl-Dithiothreitol (DTT) on systolic Ca2+ transients (SCaTs), diastolic Ca2+ sparks (CaS) and Ca2+ waves (CaW), recorded by confocal techniques, and L-type Ca2+ current (I-Ca), assessed by whole-cell patch clamp, were evaluated in MetS and Control cells. MetS myocytes exhibited decreased SCaTs and CaS frequency but unaffected CaW propagation. In Control cells, NAC/DTT reduced RyR2/SERCA2a activity blunting SCaTs, CaS frequency and CaW propagation, suggesting that basal ROS optimised Ca2+ signalling by maintaining RyR2/SERCA2a function and that these proteins facilitate CaW propagation. Conversely, NAC/DTT in MetS recovered RyR2/SERCA2a function, improving SCaTs and CaS frequency, but unexpectedly decreasing CaW propagation. We hypothesised that OS decreases RyR2/SERCA2a activity at early MetS, and while decreased SERCA2a favours CaW propagation, diminished RyR2 restrains it.
C1 [Leticia Gomez-Viquez, Norma; Balderas-Villalobos, Jaime; Dolores Bello-Sanchez, Ma; Mayorga-Luna, Maritza; Mailloux-Salinas, Patrick; Bravo, Guadalupe] Inst Politecn Nacl, Dept Farmacobiol, Ctr Invest & Estudios Avanzados, Ciudad De Mexico, Mexico.
   [Balderas-Villalobos, Jaime; Antonio Martinez-Avila, Marco; del Carmen Camacho-Castillo, Luz; Carvajal, Karla] Inst Nacl Pediat, Lab Nutr Expt, Ciudad De Mexico 104530, Mexico.
   [Garcia-Castaneda, Maricela; Benjamin Rios-Perez, Erick; Avila, Guillermo] Inst Politecn Nacl, Dept Bioquim, Ctr Invest & Estudios Avanzados, Ciudad De Mexico, Mexico.
   [Altamirano, Julio] Tecnol Monterrey, Escuela Med & Ciencias Salud, Monterrey, Mexico.
C3 Instituto Politecnico Nacional - Mexico; Instituto Politecnico Nacional
   - Mexico; Tecnologico de Monterrey
RP Carvajal, K (corresponding author), Inst Nacl Pediat, Lab Nutr Expt, Ciudad De Mexico 104530, Mexico.
EM karla_ca@yahoo.com
RI del Carmen Camacho Castillo, Luz/AAX-6892-2021; Avila,
   Guillermo/B-5782-2013
OI Camacho, Luz/0000-0002-9864-3738; Rios Perez, Erick/0000-0002-2246-9112;
   Avila, Guillermo/0000-0001-7615-8945; CASTANEDA ANTONIO, MA.
   DOLORES/0000-0003-0350-3802; Balderas Villalobos,
   Jaime/0000-0002-4997-2703
FU Consejo Nacional de Ciencia y Tecnologia (CONACyT) [151136, 11/048]
FX This work was supported by Consejo Nacional de Ciencia y Tecnologia
   (CONACyT) under Grant 151136 to NLGV and KC, and Institutional funds to
   protocol INP [11/048].
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NR 59
TC 4
Z9 4
U1 1
U2 14
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1381-3455
EI 1744-4160
J9 ARCH PHYSIOL BIOCHEM
JI Arch. Physiol. Biochem.
PD SEP 3
PY 2023
VL 129
IS 5
BP 1058
EP 1070
DI 10.1080/13813455.2021.1895224
EA MAR 2021
PG 13
WC Biochemistry & Molecular Biology; Biophysics; Endocrinology &
   Metabolism; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Endocrinology &
   Metabolism; Physiology
GA S1DT2
UT WOS:000627243500001
PM 33689540
DA 2025-06-11
ER

PT J
AU Rubio-Ruiz, ME
   Guarner-Lans, V
   Cano-Martínez, A
   Díaz-Díaz, E
   Manzano-Pech, L
   Gamas-Magaña, A
   Castrejón-Tellez, V
   Tapia-Cortina, C
   Pérez-Torres, I
AF Esther Rubio-Ruiz, Maria
   Guarner-Lans, Veronica
   Cano-Martinez, Agustina
   Diaz-Diaz, Eulises
   Manzano-Pech, Linaloe
   Gamas-Magana, Anel
   Castrejon-Tellez, Vicente
   Tapia-Cortina, Concepcion
   Perez-Torres, Israel
TI Resveratrol and Quercetin Administration Improves Antioxidant DEFENSES
   and reduces Fatty Liver in Metabolic Syndrome Rats
SO MOLECULES
LA English
DT Article
DE resveratrol; quercetin; metabolic syndrome; fatty liver; oxidative
   stress
ID INDUCED OXIDATIVE DAMAGE; INSULIN-RESISTANCE; STRESS; NRF2;
   PHOSPHORYLATION; PREVENTION; DISEASE; CELLS; MICE; VASODILATION
AB Mixtures of resveratrol (RSV) + quercetin (QRC) have antioxidant properties that probably impact on fatty liver in metabolic syndrome (MS) individuals. Here, we study the effects of a mixture of RSV + QRC on oxidative stress (OS) and fatty liver in a rat model of MS. Weanling male Wistar rats were separated into four groups (n = 8): MS rats with 30% sucrose in drinking water plus RSV + QRC (50 and 0.95 mg/kg/day, respectively), MS rats without treatment, control rats (C), and C rats plus RSV + QRC. MS rats had increased systolic blood pressure, triglycerides, insulin levels, insulin resistance index homeostasis model (HOMA), adiponectin, and leptin. The RSV + QRC mixture compensated these variables to C values (p < 0.01) in MS rats. Lipid peroxidation and carbonylation were increased in MS. Total antioxidant capacity and glutathione (GSH) were decreased in MS and compensated in MS plus RVS + QRC rats. Catalase, superoxide dismutase isoforms, peroxidases, glutathione-S-transferase, glutathione reductase, and the expression of Nrf2 were decreased in MS and reversed in MS plus RVS + QRC rats (p < 0.01). In conclusion, the mixture of RSV + QRC has benefic effects on OS in fatty liver in the MS rats through the improvement of the antioxidant capacity and by the over-expression of the master factor Nrf2, which increases the antioxidant enzymes and GSH recycling.
C1 [Esther Rubio-Ruiz, Maria; Guarner-Lans, Veronica; Cano-Martinez, Agustina; Gamas-Magana, Anel; Castrejon-Tellez, Vicente] Inst Nacl Cardiol Ignacio Chavez, Dept Physiol, Juan Badiano 1,Secc 16, Mexico City 14080, DF, Mexico.
   [Diaz-Diaz, Eulises] Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Reprod Biol, Vasco de Quiroga 15,Secc 16, Mexico City 14000, DF, Mexico.
   [Manzano-Pech, Linaloe; Perez-Torres, Israel] Inst Nacl Cardiol Ignacio Chavez, Dept Pathol, Juan Badiano 1,Secc 16, Mexico City 14080, DF, Mexico.
   [Tapia-Cortina, Concepcion] Univ Autonoma Ciudad Mexico, Acad Salud Comunitaria, Colegio Ciencias & Humanidades Licenciatura Promo, Mexico City 06720, DF, Mexico.
C3 National Institute of Cardiology - Mexico; Instituto Nacional de
   Ciencias Medicas y Nutricion Salvador Zubiran - Mexico; National
   Institute of Cardiology - Mexico
RP Pérez-Torres, I (corresponding author), Inst Nacl Cardiol Ignacio Chavez, Dept Pathol, Juan Badiano 1,Secc 16, Mexico City 14080, DF, Mexico.
EM esther_rubio_ruiz@yahoo.com; gualanv@yahoo.com; cmamx2002@yahoo.com.mx;
   eulisesd@yahoo.com; pertorisr@yahoo.com.mx; anel.gama@hotmail.com;
   vcastrejn@yahoo.com.mx; tapiacc@hotmail.com; pertorisr@yahoo.com.mx
RI Guarner-Lans, Verónica/AFW-3723-2022; Pérez Torres, Israel/AAE-2579-2022
OI Guarner-Lans, Veronica/0000-0002-2655-7590; Cano-Martinez,
   Agustina/0000-0002-6703-2176; Perez-Torres, Israel/0000-0001-6510-2954;
   Rubio-Ruiz, Maria Esther/0000-0002-8844-2078; Castrejon Tellez,
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NR 58
TC 52
Z9 56
U1 0
U2 13
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1420-3049
J9 MOLECULES
JI Molecules
PD APR 3
PY 2019
VL 24
IS 7
AR 1297
DI 10.3390/molecules24071297
PG 18
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA HU0HJ
UT WOS:000464951700001
PM 30987086
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Prakash, S
   Rai, U
   Kosuru, R
   Tiwari, V
   Singh, S
AF Prakash, Swati
   Rai, Uddipak
   Kosuru, Ramoji
   Tiwari, Vinod
   Singh, Sanjay
TI Amelioration of diet-induced metabolic syndrome and fatty liver with
   sitagliptin via regulation of adipose tissue inflammation and hepatic
   Adiponectin/AMPK levels in mice
SO BIOCHIMIE
LA English
DT Article
DE Metabolic syndrome; Fatty liver; Adipose tissue inflammation;
   Sitagliptin; AMPK; Adiponectin
ID INSULIN-RESISTANCE; OXIDATIVE STRESS; RATS; FRUCTOSE; DISEASE; OBESITY;
   GLP-1; DYSREGULATION; METFORMIN; PLASMA
AB Chronic consumption of unhealthy diet and sedentary lifestyle induces fatty liver and metabolic complications. Adipocytes get overloaded with lipid succeeding low-grade inflammation and disrupting adipokine release. This research aims to investigate the effect of sitagliptin on white adipose tissue inflammation, adipokine level, metabolic syndrome, and fatty liver through 5' adenosine monophosphate-activated protein kinase (AMPK) pathway. In sixteen weeks of the experimental protocol, Swiss albino mice were kept in a standard environment and were fed 60% high-fat diet and 20% fructose water (HFFW) where they developed metabolic syndrome features, adipose tissue inflammation, and altered adipokine profile. Sitagliptin was administered for the last eight weeks. They were allocated to following six groups, control diet with regular water (1), HFFW only (2), HFFW and metformin 100 mg/kg (3), HFFW and sitagliptin 10 mg/kg (4), HFFW and sitagliptin 20 mg/kg (5), and HFFW and sitagliptin 30 mg/kg (6). Fasting serum insulin (FSI), glucagon-like peptide-1 (GLP-1), adipokines (adiponectin and leptin), serum lipid profile, hepatic lipid content, and white adipose tissue inflammation were assessed. Protein expression of P-AMPK, P-Acetyl co-a carboxylase (ACC), and mRNA expression of fatty acid metabolism genes were also evaluated in the liver. Sitagliptin significantly and effectively reversed metabolic syndrome complexity. FSI and GLP-1 levels were improved. A significant reduction in hepatic lipid content and oxidative stress was also observed. Also, sitagliptin significantly ameliorated adipose tissue inflammation and adiponectin levels at 20 mg/kg and 30 mg/kg. P-AMPK and P-ACC expression increased significantly. Moreover, expression of fatty acid synthesis genes was down-regulated, and fatty acid oxidation genes were up-regulated. Sitagliptin significantly ameliorated obesity-induced adipose tissue inflammation, metabolic syndrome, and fatty liver via regulation of adiponectin and AMPK levels in obese mice. Also, increased GLP-1 levels would have induced insulin-independent effects on adipose tissue and liver. (C) 2019 Elsevier B.V. and Societe Francaise de Biochimie et Biologie Moleculaire (SFBBM). All rights reserved.
C1 [Prakash, Swati; Rai, Uddipak; Kosuru, Ramoji; Tiwari, Vinod; Singh, Sanjay] Banaras Hindu Univ, Dept Pharmaceut Engn & Technol, Indian Inst Technol, Varanasi 221005, Uttar Pradesh, India.
   [Singh, Sanjay] Baba Saheb Bhim Rao Ambedkar Cent Univ BBAU, Lucknow 226025, Uttar Pradesh, India.
C3 Indian Institute of Technology System (IIT System); Indian Institute of
   Technology BHU Varanasi (IIT BHU Varanasi); Banaras Hindu University
   (BHU); Babasaheb Bhimrao Ambedkar University
RP Tiwari, V; Singh, S (corresponding author), Banaras Hindu Univ, Dept Pharmaceut Engn & Technol, Indian Inst Technol, Varanasi 221005, Uttar Pradesh, India.
EM pswati.rs.phe14@itbhu.ac.in; uddipak.rs.phe14@itbhu.ac.in;
   kosuru.ramoji@gmail.com; vtiwari.phe@iitbhu.ac.in;
   ssingh.phe@iitbhu.ac.in
RI Kosuru, Ramoji/AAB-8320-2020; , Vinod/ABC-4850-2021; Rai,
   Uddipak/GOG-8358-2022; Singh, Sanjay/M-3276-2019
OI Prakash, Swati/0009-0006-7277-7857; Kosuru, Ramoji/0000-0002-7394-7217;
   RAI, UDDIPAK/0000-0003-1706-4580; Tiwari, Vinod/0000-0002-8491-2255;
   TIWARI, Vinod K/0000-0001-9244-8889
FU University Grants Commission
FX The necessary assistance for conducting the research work was provided
   by the Department of Pharmaceutical Engineering and Technology, IIT
   (BHU), Varanasi, India. The Interdisciplinary School of Life Sciences
   (ISLS), BHU, Varanasi, provided the facility of Nanodrop 1000
   spectrophotometer. We would like to show our gratitude to Dr. S.P.
   Singh, Professor in Department of Biochemistry, BHU, for providing the
   research facilities. We also acknowledge the Cipla laboratories,
   Maharashtra, India, for supplying the gift sample of metformin. Sincere
   thanks to University Grants Commission, for providing the fellowship
   during the course of work.
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U2 14
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0300-9084
EI 1638-6183
J9 BIOCHIMIE
JI Biochimie
PD JAN
PY 2020
VL 168
BP 198
EP 209
DI 10.1016/j.biochi.2019.11.005
PG 12
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA JX0OU
UT WOS:000503444300018
PM 31715215
DA 2025-06-11
ER

PT J
AU Dai, XY
   Liang, B
   Sun, YL
AF Dai, Xiyan
   Liang, Bo
   Sun, Yaolin
TI Luteolin ameliorates rat model of metabolic syndrome-induced cardiac
   injury by apoptosis suppression and autophagy promotion via NR4A2/p53
   regulation
SO BMC COMPLEMENTARY MEDICINE AND THERAPIES
LA English
DT Article
DE Metabolic syndrome; Cardiac; Autophagy; Apoptosis; Inflammation
ID QUERCETIN; OBESITY; STRESS
AB Background Reduced cardiac autophagy, inflammation, and apoptosis contribute to cardiovascular complications caused by metabolic syndrome (MetS). It is documented that the nuclear receptor 4A2 (NR4A2) could modulate autophagy and apoptosis in cardiac complications. The aim of this investigation was to assess the therapeutic potential of luteolin, with documented beneficial properties, against MetS-associated cardiac injury. Methods Forty male albino Wistar rats were divided into 5 groups randomly as controls, MetS, and MetS animals treated with luteolin (25, 50, 100 mg/kg ip). The animal's weight, blood pressure, lipid profile, tolerance to glucose and insulin, and cardiac histopathology were evaluated. Moreover, troponin T, creatine kinase-myocardial band (CK-MB), inflammatory profile (IL-6, IL-1 beta, TNF-alpha), transforming growth factor-beta 1 (TGF-beta 1), oxidative stress, and matrix metalloproteinase-9 (MMP-9) were analyzed to determine the cardiac state. Cardiac NR4A2 and p53, as well as apoptotic (B-cell leukemia/lymphoma 2 [BCL-2], Caspase [CASP]-3, and CASP-9) and autophagic mediators (Sequestosome-1/p62, Microtubule-associated protein 1 A/1B-light chain 3 [LC3], and Beclin-1) were measured by RT-qPCR and ELISA. Results Luteolin remarkably restored MetS-induced biochemical derangements and related cardiac injury via the suppression of apoptosis, inflammation, and stress but promotion of autophagy (p-value < 0.001). Conclusion Current findings revealed the promising therapeutical properties of luteolin against MetS-associated cardiovascular risks.
C1 [Dai, Xiyan] Maoming Peoples Hosp, Dept Comprehens, Maoming 525000, Peoples R China.
   [Liang, Bo] Maoming Peoples Hosp, Dept MRI, Maoming 525000, Peoples R China.
   [Sun, Yaolin] Northwest Univ, Hosp 1, Dept Cardiovasc Med, Xian 710043, Peoples R China.
C3 Northwest University Xi'an
RP Sun, YL (corresponding author), Northwest Univ, Hosp 1, Dept Cardiovasc Med, Xian 710043, Peoples R China.
EM lin19811014@sina.com
OI Cowan, Charles/0009-0001-0841-0130
FU Guangdong Medical Science and Technology Research Foundation
FX The authors would like to thank all who contributed to the preparation
   of this article.
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   Wang GG, 2011, EVID-BASED COMPL ALT, V2011, P1, DOI 10.1155/2011/323171
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   Yang XX, 2024, DIABETES-METAB RES, V40, DOI 10.1002/dmrr.3762
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NR 52
TC 2
Z9 2
U1 1
U2 1
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 2662-7671
J9 BMC COMPLEMENT MED
JI BMC Complement. Med. Ther.
PD JAN 20
PY 2025
VL 25
IS 1
AR 14
DI 10.1186/s12906-025-04749-6
PG 12
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA S9Z8D
UT WOS:001401722400001
PM 39833877
OA gold
DA 2025-06-11
ER

PT J
AU Andreacchi, AT
   Oz, UE
   Bassim, C
   Griffith, LE
   Mayhew, A
   Pigeyre, M
   Stranges, S
   Verschoor, CP
   Anderson, LN
AF Andreacchi, Alessandra T.
   Oz, Urun Erbas
   Bassim, Carol
   Griffith, Lauren E.
   Mayhew, Alexandra
   Pigeyre, Marie
   Stranges, Saverio
   Verschoor, Chris P.
   Anderson, Laura N.
TI Clustering of obesity-related characteristics: A latent class analysis
   from the Canadian Longitudinal Study on Aging
SO PREVENTIVE MEDICINE
LA English
DT Article
DE Older adults; Latent class analysis; Obesity; Anthropometric measure;
   Canadian Longitudinal Study on Aging
ID OLDER-ADULTS; RISK; MULTIMORBIDITY; BEHAVIORS; COMMUNITY; PATTERNS;
   NUMBER; WELL; LIFE
AB Measures of obesity, including body mass index (BMI) and waist circumference (WC), do not fully capture the complexity of obesity-related health risks. This study identified distinct classes of obesity-related characteristics and evaluated their associations with BMI, WC, and percent body fat (%BF) using cross-sectional data from 30,096 participants aged 45-85 in the Canadian Longitudinal Study on Aging (2011-2015). Sixteen obesityrelated variables, including behavioural, metabolic, physical health, and mental health/social factors, were included in a latent class analysis to identify distinct classes of participants. Adjusted odds ratios (OR) were estimated from logistic regression for associations between each class and obesity defined by BMI, WC and %BF. Six latent classes were identified: "low-risk" (39.8%), "cardiovascular risk" (19.4%), "metabolic risk" (16.9%), "sleep and mental health risk" (12.1%), "multiple and complex risk" (6.7%), and "cardiometabolic risk" (5.1%). Compared to "low-risk", all classes had increased odds of BMI-, WC- and %BF-defined obesity. For example, the "complex and multiple risk" class was associated with obesity by BMI (OR: 10.70, 95% confidence interval (CI): 9.51, 12.04), WC (OR: 9.21, 95% CI: 8,15, 10,41) and %BF (OR: 7.54, 95% CI: 6.21, 9.16). Distinct classes of obesity-related characteristics were identified and were strongly associated with obesity defined by multiple measures.
C1 [Andreacchi, Alessandra T.; Oz, Urun Erbas; Bassim, Carol; Griffith, Lauren E.; Mayhew, Alexandra; Anderson, Laura N.] McMaster Univ, Dept Hlth Res Methods Evidence & Impact, 1280 Main St West, Hamilton, ON L8S 4L8, Canada.
   [Griffith, Lauren E.; Mayhew, Alexandra] McMaster Univ, Labarge Ctr Mobil Aging, MIP Suite 109A,1280 Main St West, Hamilton, ON L8S 4K1, Canada.
   [Griffith, Lauren E.; Mayhew, Alexandra] McMaster Univ, McMaster Inst Res Aging, MIP Suite 109A-175 Longwood Rd South, Hamilton, ON L8P 0A1, Canada.
   [Pigeyre, Marie] David Braley Cardiac Vasc & Stroke Res Inst, Populat Hlth Res Inst, 20 Copeland Ave, Hamilton, ON L8L 2X2, Canada.
   [Pigeyre, Marie] McMaster Univ, Dept Med, 1200 Main St West, Hamilton, ON L8N 3Z5, Canada.
   [Stranges, Saverio] Western Univ, Western Ctr Publ Hlth & Family Med, Schulich Sch Med & Dent, Dept Epidemiol & Biostat, 1465 Richmond St, London, ON N6G 2M1, Canada.
   [Stranges, Saverio] Western Univ, Western Ctr Publ Hlth & Family Med, Schulich Sch Med & Dent, Dept Family Med, 1465 Richmond St, London, ON N6G 2M1, Canada.
   [Stranges, Saverio] Luxembourg Inst Hlth, Dept Populat Hlth, 1A-B Rue Thomas Edison, L-1445 Strassen, Luxembourg.
   [Stranges, Saverio] Western Univ, Schulich Sch Med & Dent, Dept Med, Room E6-117-800 Commissioners Rd East, London, ON N6A 5W9, Canada.
   [Verschoor, Chris P.] Hlth Sci North Res Inst, 56 Walford Rd, Sudbury, ON P3E 2H3, Canada.
   [Anderson, Laura N.] McMaster Univ, Ctr Hlth Econ & Policy Anal, 1280 Main St West, Hamilton, ON L8S 4K1, Canada.
C3 McMaster University; McMaster University; McMaster University;
   Population Health Research Institute; McMaster University; Western
   University (University of Western Ontario); Western University
   (University of Western Ontario); Luxembourg Institute of Health; Western
   University (University of Western Ontario); Health Sciences North;
   McMaster University
RP Anderson, LN (corresponding author), McMaster Univ, Dept Hlth Res Methods Evidence & Impact, 1280 Main St West, Hamilton, ON L8S 4L8, Canada.
EM LN.Anderson@mcmaster.ca
RI Andreacchi, Alessandra/JXW-7175-2024; Anderson, Laura/K-4707-2019;
   Stranges, Saverio/F-3273-2010
OI Stranges, Saverio/0000-0001-5226-8373; Andreacchi,
   Alessandra/0000-0001-6923-9245; Anderson, Laura N./0000-0002-6106-5073;
   Verschoor, Chris/0000-0001-6190-2655
FU Canadian Institutes of Health Research (CIHR) [ACD-162992]; McLaughlin
   Foundation Professorship in Population and Public Health; Government of
   Canada through the Canadian Institutes of Health Research (CIHR) [LSA
   94473]; Canada Foundation for Innovation
FX This work was supported by the Canadian Institutes of Health Research
   (CIHR) [grant number: ACD-162992] . Dr. Lauren Griffith is supported by
   the McLaughlin Foundation Professorship in Population and Public Health.
   The funding agencies had no role in the design of the study, collection
   and analysis of data, or the decision to publish. The CLSA is led by
   Drs. Parminder Raina, Christina Wolfson and Susan Kirkland. Funding for
   the Canadian Longitudinal Study on Aging (CLSA) is provided by the
   Government of Canada through the Canadian Institutes of Health Research
   (CIHR) [grant number: LSA 94473] and the Canada Foundation for
   Innovation. This research has been conducted using the CLSA's dataset
   Baseline Tracking version 3.4 and Baseline Comprehensive Version 4.0,
   under Application Number 19CA004.
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NR 51
TC 4
Z9 4
U1 0
U2 3
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0091-7435
EI 1096-0260
J9 PREV MED
JI Prev. Med.
PD DEC
PY 2021
VL 153
AR 106739
DI 10.1016/j.ypmed.2021.106739
EA JUL 2021
PG 8
WC Public, Environmental & Occupational Health; Medicine, General &
   Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; General & Internal Medicine
GA WB4VT
UT WOS:000703571900003
PM 34298025
DA 2025-06-11
ER

PT J
AU Cupisti, A
   D'Alessandro, C
   Samoni, S
   Meola, M
   Egidi, M
AF Cupisti, Adamasco
   D'Alessandro, Claudia
   Samoni, Sara
   Meola, Mario
   Egidi, Maria Francesca
TI Nephrolithiasis and hypertension: possible links and clinical
   implications
SO JOURNAL OF NEPHROLOGY
LA English
DT Review
DE Kidney stone; Arterial hypertension; Cardiovascular damage; Insulin
   resistance; Metabolic syndrome; Nephrolithiasis
ID NUTRITION EXAMINATION SURVEY; CORONARY-HEART-DISEASE; KIDNEY-STONE
   DISEASE; METABOLIC SYNDROME; IDIOPATHIC HYPERCALCIURIA;
   CARDIOVASCULAR-DISEASE; INSULIN-RESISTANCE; OXIDATIVE STRESS;
   NATIONAL-HEALTH; RISK
AB A definite epidemiological association exists between kidney stone disease and arterial hypertension, but the pathophysiological mechanisms are still not fully understood. Hypercalciuria or inflammation and oxidative stress have been proposed as possible links. However, there is more convincing evidence that the association between nephrolithiasis and hypertension may be considered as a part of the association between kidney stone disease, metabolic syndrome and atherosclerosis. From a clinical point of view, this association represents a crucial aspect of the clinical management of patients affected by kidney stone disease. In order to implement early prevention and treatment of cardiovascular and/or renal damage physicians should be encouraged to assess individual cardiovascular risk factors in any adult with kidney stones. Consequently, patients with kidney stones need a comprehensive approach rather than an intervention limited to the urinary tract and focused on stone resolution and recurrence prevention. It is time to view kidney stone disease as a systemic disorder, associated to or predictive of hypertension, chronic kidney disease, bone and cardiovascular damage. All these conditions negatively affect patient prognosis. This multi-systemic approach could increase the clinical impact of the kidney stone clinic.
C1 [Cupisti, Adamasco; D'Alessandro, Claudia; Samoni, Sara] Univ Pisa, Pisa, Italy.
   [Meola, Mario] Univ Pisa, S Anna Sch Adv Studies, Pisa, Italy.
   [Egidi, Maria Francesca] Univ Pisa, Nephrol Transplant Dialysis Unit, Pisa, Italy.
C3 University of Pisa; University of Pisa; Scuola Superiore Sant'Anna;
   University of Pisa
RP Cupisti, A (corresponding author), Univ Pisa, Pisa, Italy.
EM adamasco.cupisti@med.unipi.it
RI D'Alessandro, Claudia/ABF-4839-2021; CUPISTI, ADAMASCO/HPG-1446-2023
OI D'ALESSANDRO, Claudia/0000-0003-2313-5461; CUPISTI,
   ADAMASCO/0000-0002-8995-936X; MEOLA, Mario/0000-0002-1330-2820; Samoni,
   Sara/0000-0003-0973-162X
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NR 48
TC 33
Z9 37
U1 0
U2 15
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1121-8428
EI 1724-6059
J9 J NEPHROL
JI J. Nephrol.
PD OCT
PY 2014
VL 27
IS 5
BP 477
EP 482
DI 10.1007/s40620-014-0068-x
PG 6
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA AP9PE
UT WOS:000342410900002
PM 24577680
DA 2025-06-11
ER

PT J
AU Cruz, JC
   Flôr, AFL
   França-Silva, M
   Balarini, CM
   Braga, VA
AF Cruz, Josiane C.
   Flor, Atalia F. L.
   Franca-Silva, MariaS.
   Balarini, Camille M.
   Braga, Valdir A.
TI Reactive Oxygen Species in the Paraventricular Nucleus of the
   Hypothalamus Alter Sympathetic Activity During Metabolic Syndrome
SO FRONTIERS IN PHYSIOLOGY
LA English
DT Review
DE paraventricular nucleus of the hypothalamus; angiotensin II; oxidative
   stress; metabolic syndrome
ID ANGIOTENSIN-II; SUBFORNICAL ORGAN; AFFERENT REFLEX; PERIPHERAL
   CHEMORECEPTORS; CARDIOVASCULAR-RESPONSES; BAROREFLEX SENSITIVITY;
   ARTERIAL-PRESSURE; AUTONOMIC NEURONS; OXIDATIVE STRESS; BLOOD-PRESSURE
AB The paraventricular nucleus of the hypothalamus (PVN) contains heterogeneous populations of neurons involved in autonomic and neuroendocrine regulation. The PVN plays an important role in the sympathoexcitatory response to increasing circulating levels of angiotensin II (Ang-II), which activates AT1 receptors in the circumventricular organs (OCVs), mainly in the subfornical organ (SFO). Circulating Ang-II induces a de novo synthesis of Ang-II in SFO neurons projecting to pre-autonomic PVN neurons. Activation of All receptors induces intracellular increases in reactive oxygen species (ROS), leading to increases in sympathetic nerve activity (SNA). Chronic sympathetic nerve activation promotes a series of metabolic disorders that characterizes the metabolic syndrome (MetS): dyslipidemia, hyperinsulinemia, glucose intolerance, hyperleptinemia and elevated plasma hormone levels, such as noradrenaline, glucocorticoids, leptin, insulin, and Ang-II. This review will discuss the contribution of our laboratory and others regarding the sympathoexcitation caused by peripheral Ang-II-induced reactive oxygen species along the subfornical organ and paraventricular nucleus of the hypothalamus. We hypothesize that this mechanism could be involved in metabolic disorders underlying MetS.
C1 [Cruz, Josiane C.; Flor, Atalia F. L.; Franca-Silva, MariaS.; Balarini, Camille M.; Braga, Valdir A.] Univ Fed Paraiba, Ctr Biotecnol, BR-58059900 Joao Pessoa, Paraiba, Brazil.
   [Balarini, Camille M.] Univ Fed Paraiba, Ctr Ciencias Saude, BR-58059900 Joao Pessoa, Paraiba, Brazil.
C3 Universidade Federal da Paraiba; Universidade Federal da Paraiba
RP Cruz, JC (corresponding author), Univ Fed Paraiba, Ctr Biotecnol, BR-58059900 Joao Pessoa, Paraiba, Brazil.
EM josianecruz@cbiotec.ufpb.br
RI Braga, Valdir/K-7899-2012; Cruz, Josiane/L-9780-2017
OI de Andrade Braga, Valdir/0000-0002-6484-6203; Franca Falcao, Maria do
   Socorro/0000-0002-4331-3870
FU CNPq; CAPES
FX The authors are grateful to CNPq and CAPES for financial support.
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NR 60
TC 24
Z9 24
U1 0
U2 11
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-042X
J9 FRONT PHYSIOL
JI Front. Physiol.
PD DEC 23
PY 2015
VL 6
AR 384
DI 10.3389/fphys.2015.00384
PG 6
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA CZ4VN
UT WOS:000367101000001
PM 26779026
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Black, CN
   Penninx, B
   Bot, M
   Odegaard, AO
   Gross, MD
   Matthews, KA
   Jacobs, DR
AF Black, C. N.
   Penninx, B. W. J. H.
   Bot, M.
   Odegaard, A. O.
   Gross, M. D.
   Matthews, K. A.
   Jacobs, D. R., Jr.
TI Oxidative stress, anti-oxidants and the cross-sectional and longitudinal
   association with depressive symptoms: results from the CARDIA study
SO TRANSLATIONAL PSYCHIATRY
LA English
DT Article
ID ARTERY RISK DEVELOPMENT; TERM ANTIDEPRESSANT TREATMENT; 3RD
   NATIONAL-HEALTH; MAJOR DEPRESSION; CAROTENOID CONCENTRATIONS; INDIVIDUAL
   CAROTENOIDS; PLASMA CAROTENOIDS; METABOLIC SYNDROME; DIABETES-MELLITUS;
   BIOLOGICAL-FLUIDS
AB Depression may be accompanied by increased oxidative stress and decreased circulating anti-oxidants. This study examines the association between depressive symptoms, F2-isoprostanes and carotenoids in a US community sample. The study includes 3009 participants (mean age 40.3, 54.2% female) from CARDIA (Coronary Artery Risk Development in Young Adults). Cross-sectional analyses were performed on data from the year 15 examination (2000-2001) including subjects whose depressive symptoms were assessed with the Center for Epidemiologic Studies Depression Scale (CES-D) and had measurements of plasma F2-isoprostanes (gas chromatography/mass spectrometry) or serum carotenoids (high-performance liquid chromatography). Carotenoids zeaxanthin/lutein, beta-cryptoxanthin, lycopene, alpha-carotene, beta-carotene were standardized and summed. Longitudinal analyses were conducted using the data from other examinations at 5-year intervals. Cross-lagged analyses investigated whether CES-D predicted F2-isoprostanes or carotenoids at the following exam, and vice versa. Regression analyses were controlled for sociodemographics, health and lifestyle factors. F2-isoprostanes were higher in subjects with depressive symptoms (CES-D >= 16) after adjustment for sociodemographics (55.7 vs 52.0 pg ml(-1); Cohen's d = 0.14, P < 0.001). There was no difference in F2-isoprostanes after further adjustment for health and lifestyle factors. Carotenoids were lower in those with CES-D scores. 16, even after adjustment for health and lifestyle factors (standardized sum 238.7 vs 244.0, Cohen's d = -0.16, P < 0.001). Longitudinal analyses confirmed that depression predicts subsequent F2-isoprostane and carotenoid levels. Neither F2-isoprostanes nor carotenoids predicted subsequent depression. In conclusion, depressive symptoms were cross-sectionally and longitudinally associated with increased F2-isoprostanes and decreased carotenoids. The association with F2-isoprostanes can largely be explained by lifestyle factors, but lower carotenoids were independently associated with depressive symptoms.
C1 [Black, C. N.; Penninx, B. W. J. H.; Bot, M.] Vrije Univ Amsterdam, Med Ctr, EMGO Inst Hlth & Care Res, Dept Psychiat, POB 74077, NL-1070 BB Amsterdam, Netherlands.
   [Odegaard, A. O.] Univ Calif Irvine, Sch Med, Dept Epidemiol, Irvine, CA 92717 USA.
   [Gross, M. D.] Univ Minnesota, Sch Med, Dept Lab Med & Pathol, Minneapolis, MN 55455 USA.
   [Matthews, K. A.] Univ Pittsburgh, Sch Med, Dept Psychiat, Pittsburgh, PA USA.
   [Jacobs, D. R., Jr.] Univ Minnesota, Sch Med, Sch Publ Hlth, Div Epidemiol & Community Hlth, Minneapolis, MN 55455 USA.
C3 Vrije Universiteit Amsterdam; University of California System;
   University of California Irvine; University of Minnesota System;
   University of Minnesota Twin Cities; Pennsylvania Commonwealth System of
   Higher Education (PCSHE); University of Pittsburgh; University of
   Minnesota System; University of Minnesota Twin Cities
RP Black, CN (corresponding author), Vrije Univ Amsterdam, Med Ctr, EMGO Inst Hlth & Care Res, Dept Psychiat, POB 74077, NL-1070 BB Amsterdam, Netherlands.
EM c.black@ggzingeest.nl
RI Jacobs, David/G-5405-2011; Penninx, Brenda WJH/S-7627-2017
OI Jacobs, David/0000-0002-7232-0543; Penninx, Brenda
   WJH/0000-0001-7779-9672
FU University of Alabama at Birmingham [HHSN268201300025C,
   HHSN268201300026C]; Northwestern University [HHSN268201300027C];
   University of Minnesota [HHSN268201300028C]; Kaiser Foundation Research
   Institute [HHSN268201300029C]; Johns Hopkins University School of
   Medicine [HHSN268200900041C]; Intramural Research Program of the
   National Institute on Aging (NIA); NIA [AG0005]; NHLBI [AG0005];
   National Heart, Lung, and Blood Institute, National Institutes of Health
   [R01 HL 53560]; NWOVICI grant [91811602]; National Heart, Lung, and
   Blood Institute (NHLBI)
FX The Coronary Artery Risk Development in Young Adults Study (CARDIA) is
   conducted and supported by the National Heart, Lung, and Blood Institute
   (NHLBI) in collaboration with the University of Alabama at Birmingham
   (HHSN268201300025C and HHSN268201300026C), Northwestern University
   (HHSN268201300027C), University of Minnesota (HHSN268201300028C), Kaiser
   Foundation Research Institute (HHSN268201300029C) and Johns Hopkins
   University School of Medicine (HHSN268200900041C). CARDIA is also
   partially supported by the Intramural Research Program of the National
   Institute on Aging (NIA) and an intra-agency agreement between NIA and
   NHLBI (AG0005). This manuscript has been reviewed by CARDIA for
   scientific content. The Young Adult Longitudinal Trends in Antioxidants
   Study (YALTA) is supported by the National Heart, Lung, and Blood
   Institute, National Institutes of Health (R01 HL 53560). CNB and BWJHP
   are supported through an NWOVICI grant (number 91811602).
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NR 74
TC 36
Z9 38
U1 0
U2 13
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 2158-3188
J9 TRANSL PSYCHIAT
JI Transl. Psychiatr.
PD FEB 23
PY 2016
VL 6
AR e743
DI 10.1038/tp.2016.5
PG 10
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychiatry
GA DJ0LN
UT WOS:000373895100005
PM 26905415
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Zarich, SW
AF Zarich, SW
TI The role of intensive glycemic control in the management of patients who
   have acute myocardial infarction
SO CARDIOLOGY CLINICS
LA English
DT Article
ID GLUCOSE-INSULIN-POTASSIUM; RECEPTOR-GAMMA AGONIST; DIABETIC-PATIENTS;
   HEART-FAILURE; CARDIOVASCULAR-DISEASE; STRESS HYPERGLYCEMIA; METABOLIC
   SYNDROME; RISK-FACTOR; MORTALITY; ISCHEMIA
AB This article discusses the role of intensive glycemic control in the management of patients who have acute myocardial infarction.
C1 Bridgeport Hosp, Dept Med, Div Cardiovasc Med, Bridgeport, CT 06610 USA.
   Yale Univ, Sch Med, New Haven, CT 06510 USA.
C3 Yale University
RP Bridgeport Hosp, Dept Med, Div Cardiovasc Med, 267 Grant St, Bridgeport, CT 06610 USA.
EM pszari@bpthosp.org
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NR 65
TC 6
Z9 6
U1 0
U2 1
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0733-8651
EI 1558-2264
J9 CARDIOL CLIN
JI Cardiol. Clin.
PD MAY
PY 2005
VL 23
IS 2
BP 109
EP +
DI 10.1016/j.ccl.2004.06.004
PG 10
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 901OW
UT WOS:000227292800003
PM 15694741
DA 2025-06-11
ER

PT J
AU de Oliveira, MDSP
   Rocha, BD
   Duarte, GV
AF Santos Paim de Oliveira, Maria de Fatima
   Rocha, Bruno de Oliveira
   Duarte, Gleison Vieira
TI Psoriasis: classical and emerging comorbidities
SO ANAIS BRASILEIROS DE DERMATOLOGIA
LA English
DT Article
DE Psoriatic arthritis; Depression; Crohn disease; Fatty liver; Lymphoma;
   Obesity; Psoriasis; Uveitis
ID QUALITY-OF-LIFE; BONE-MINERAL DENSITY; FATTY LIVER-DISEASE; ERECTILE
   DYSFUNCTION; METABOLIC SYNDROME; SUICIDAL IDEATION; INCREASED RISK;
   SLEEP-APNEA; TNF-ALPHA; ARTHRITIS
AB Psoriasis is a chronic inflammatory systemic disease. Evidence shows an association of psoriasis with arthritis, depression, inflammatory bowel disease and cardiovascular diseases. Recently, several other comorbid conditions have been proposed as related to the chronic inflammatory status of psoriasis. The understanding of these conditions and their treatments will certainly lead to better management of the disease. The present article aims to synthesize the knowledge in the literature about the classical and emerging comorbidities related to psoriasis.
C1 [Santos Paim de Oliveira, Maria de Fatima; Rocha, Bruno de Oliveira; Duarte, Gleison Vieira] Univ Fed Bahia, UFBA, Salvador, BA, Brazil.
   [Duarte, Gleison Vieira] Univ Toronto, Toronto, ON, Canada.
C3 Universidade Federal da Bahia; University of Toronto
RP Rocha, BD (corresponding author), Rua Padre Feijo,240,Ambulatrio Magalhaes Neto,3 A, BR-40110170 Salvador, BA, Brazil.
EM brunorocha.17@hotmail.com
RI Rocha, Bruno/B-8752-2014
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NR 118
TC 257
Z9 270
U1 3
U2 20
PU SOC BRASILEIRA DERMATOLOGIA
PI RIO DE JANEIRO RJ
PA AV RIO BRANCO, 39-18 ANDAR, RIO DE JANEIRO RJ, 20090-003, BRAZIL
SN 0365-0596
EI 1806-4841
J9 AN BRAS DERMATOL
JI An. Brasil. Dermatol.
PD JAN-FEB
PY 2015
VL 90
IS 1
BP 9
EP 20
DI 10.1590/abd1806-4841.20153038
PG 12
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA CB0GG
UT WOS:000349303200001
PM 25672294
OA Green Submitted, gold, Green Published
DA 2025-06-11
ER

PT J
AU Druss, BG
   von Esenwein, SA
   Glick, GE
   Deubler, E
   Lally, C
   Ward, MC
   Rask, KJ
AF Druss, Benjamin G.
   von Esenwein, Silke A.
   Glick, Gretl E.
   Deubler, Emily
   Lally, Cathy
   Ward, Martha C.
   Rask, Kimberly J.
TI Randomized Trial of an Integrated Behavioral Health Home: The Health
   Outcomes Management and Evaluation (HOME) Study
SO AMERICAN JOURNAL OF PSYCHIATRY
LA English
DT Article
ID LIFE-STYLE INTERVENTIONS; SERIOUS MENTAL-ILLNESS;
   CORONARY-HEART-DISEASE; CENTERED MEDICAL HOME; WEIGHT-LOSS;
   CARDIOVASCULAR RISK; EXCESS MORTALITY; SHORT-FORM; CARE; QUALITY
AB Objective: Behavioral health homes provide primary care health services to patients with serious mental illness treated in community mental health settings. The objective of this study was to compare quality and outcomes of care between an integrated behavioral health home and usual care.
   Method: The study was a randomized trial of a behavioral health home developed as a partnership between a community mental health center and a Federally Qualified Health Center. A total of 447 patients with a serious mental illness and one or more cardiometabolic risk factors were randomly assigned to either the behavioral health home or usual care for 12 months. Participants in the behavioral health home received integrated medical care on-site from a nurse practitioner and a full-time nurse care manager subcontracted through the health center.
   Results: Compared with usual care, the behavioral health home was associated with significant improvements in quality of cardiometabolic care, concordance of treatment with the chronic care model, and use of preventive services. For most cardiometabolic and general medical outcomes, both groups demonstrated improvement, although there were no statistically significant differences between the two groups over time.
   Conclusions: The results suggest that it is possible, even under challenging real-world conditions, to improve quality of care for patients with serious mental illness and cardiovascular risk factors. Improving quality of medical care may be necessary, but not sufficient, to improve the full range of medical outcomes in this vulnerable population.
C1 [Druss, Benjamin G.] Emory Univ, Rollins Sch Publ Hlth, Dept Hlth Policy & Management, Atlanta, GA 30322 USA.
   Emory Univ, Sch Med, Dept Psychiat, Atlanta, GA 30322 USA.
C3 Emory University; Rollins School Public Health; Emory University
RP Druss, BG (corresponding author), Emory Univ, Rollins Sch Publ Hlth, Dept Hlth Policy & Management, Atlanta, GA 30322 USA.
EM bdruss@emory.edu
RI Rask, Kimberly/L-5742-2019
OI Deubler, Emily/0000-0003-4511-1452
FU NIMH [R01MH070437]
FX Supported by NIMH grant R01MH070437.
CR [Anonymous], COMP EFFECTIVENESS R
   [Anonymous], BEHAV HLTH HOMES PER
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NR 45
TC 90
Z9 95
U1 0
U2 15
PU AMER PSYCHIATRIC PUBLISHING, INC
PI WASHINGTON
PA 800 MAINE AVE SW, SUITE 900, WASHINGTON, DC 20024 USA
SN 0002-953X
EI 1535-7228
J9 AM J PSYCHIAT
JI Am. J. Psychiat.
PD MAR 1
PY 2017
VL 174
IS 3
BP 246
EP 255
DI 10.1176/appi.ajp.2016.16050507
PG 10
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA EO4KV
UT WOS:000396664700011
PM 27631964
DA 2025-06-11
ER

PT J
AU Rethorst, CD
   Bernstein, I
   Trivedi, MH
AF Rethorst, Chad D.
   Bernstein, Ira
   Trivedi, Madhukar H.
TI Inflammation, Obesity, and Metabolic Syndrome in Depression: Analysis of
   the 2009-2010 National Health and Nutrition Examination Survey (NHANES)
SO JOURNAL OF CLINICAL PSYCHIATRY
LA English
DT Article
ID TREATMENT-RESISTANT DEPRESSION; FACTOR ANTAGONIST INFLIXIMAB; C-REACTIVE
   PROTEIN; STAR-ASTERISK-D; MAJOR DEPRESSION; US ADULTS; TREATMENT
   RESPONSE; PHYSICAL-ACTIVITY; SERUM-LEVELS; METAANALYSIS
AB Objective: To describe the rates of elevated inflammation, obesity, and metabolic syndrome (MetS) within a large cohort of individuals with depression and to examine the interrelationships of inflammation and MetS in depressed individuals.
   Method: Analyses were conducted on study participants from the 2009-2010 National Health and Nutrition Examination Survey (NHANES) with Patient Health Questionnaire (PHQ-9) depression scores >= 10 to (1) examine the relationship of inflammation (C-reactive protein; CRP) with demographic and clinical characteristics and (2) examine the prevalence of MetS criteria within CRP groups.
   Results: 5,579 participants provided PHQ-9 data; of those, 606 had PHQ-9 scores >= 10 and were included in further analysis. Of the 606 depressed participants, 585 participants had valid CRP data; 275 participants (47.01%) had CRP levels >= 3.0 mg/L, while 170 (29.06%) had CRP levels >= 5.0 mg/L. Elevated inflammation was significantly correlated with body weight, waist circumference, body mass index, insulin, 2-hour glucose tolerance, and self-report general health (P values < .05). 112 subjects (41.18%) met American Heart Association/National Heart, Lung, and Blood Institute criteria for MetS. Those with elevated CRP were more likely to meet criteria for MetS (odds ratios of 2.81 for those with CRP levels >= 3.0 mg/L and 1.94 for those with CRP levels >= 5.0 mg/L).
   Conclusions: Over 29% of depressed individuals had elevated levels of CRP, and 41% met criteria for MetS. Individuals with elevated inflammation are more likely to be obese and meet criteria for MetS. These results highlight the significant inflammatory and metabolic burden of individuals with depression. (C) Copyright 2014 Physicians Postgraduate Press, Inc.
C1 [Rethorst, Chad D.; Trivedi, Madhukar H.] Univ Texas SW Med Ctr Dallas, Dept Psychiat, Dallas, TX 75390 USA.
   [Bernstein, Ira] Univ Texas SW Med Ctr Dallas, Dept Clin Sci, Dallas, TX 75390 USA.
C3 University of Texas System; University of Texas Southwestern Medical
   Center Dallas; University of Texas System; University of Texas
   Southwestern Medical Center Dallas
RP Rethorst, CD (corresponding author), Univ Texas SW Med Ctr Dallas, Dept Psychiat, Dallas, TX 75390 USA.
EM chad.rethorst@utsouthwestern.edu
RI Rethorst, Chad/IXX-0200-2023; Trivedi, Madhukar/A-9029-2013
OI Trivedi, Madhukar/0000-0002-2983-1110; Rethorst,
   Chad/0000-0002-8168-2829
FU National Institute of Mental Health of the US National Institutes of
   Health [K01MH097847]
FX The National Institute of Mental Health of the US National Institutes of
   Health under Award Number K01MH097847 (to Dr Rethorst).
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NR 37
TC 127
Z9 139
U1 0
U2 25
PU PHYSICIANS POSTGRADUATE PRESS
PI MEMPHIS
PA P O BOX 752870, MEMPHIS, TN 38175-2870 USA
SN 0160-6689
EI 1555-2101
J9 J CLIN PSYCHIAT
JI J. Clin. Psychiatry
PD DEC
PY 2014
VL 75
IS 12
BP E1428
EP E1432
DI 10.4088/JCP.14m09009
PG 5
WC Psychology, Clinical; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA AX3RL
UT WOS:000346856500002
PM 25551239
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Ameer, OZ
   Salman, IM
   Alwadi, AY
   Ouban, A
   Abu-Owaimer, FM
   AlSharari, SD
   Bukhari, IA
AF Ameer, Omar Z.
   Salman, Ibrahim M.
   Alwadi, Aiman Y.
   Ouban, Abderrahman
   Abu-Owaimer, Fahmi M.
   AlSharari, Shakir D.
   Bukhari, Ishfaq A.
TI Regional functional and structural abnormalities within the aorta as a
   potential driver of vascular disease in metabolic syndrome
SO EXPERIMENTAL PHYSIOLOGY
LA English
DT Article
DE abdomen; aortic responses; high fat; metabolic syndrome; streptozotocin;
   thorax
ID HIGH-FAT DIET; ENDOTHELIAL DYSFUNCTION; DIABETES-MELLITUS;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; RATS; HYPERGLYCEMIA; GLUCOSE;
   MODEL; REACTIVITY
AB New Findings
   What is the central question of this study? Is aortic dysfunction, a significant contributor to cardiovascular disease in metabolic syndrome, expressed uniformly across both the thoracic and abdominal aorta?
   What is the main finding and its importance? Our study shows that, in the setting of metabolic syndrome, functional and structural deficits in the aorta are differentially expressed along its length, with the abdominal portion displaying more extensive vascular abnormalities. It is, therefore, likely that early interventional strategies targeting the abdominal aorta might alleviate cardiovascular pathologies driven by the metabolic syndrome.
   The extent of vascular dysfunction associated with metabolic syndrome might vary along the length of the aorta. In this study, we investigated regional functional and structural changes in the thoracic and abdominal aorta of a rat model of metabolic syndrome, namely, high-fat diet (HFD) streptozotocin-induced diabetes mellitus (HFD-D). Four-week-old male Wistar albino rats were fed with either HFD or control diet (CD) for 10 weeks. At week 6, 40 mg/kg streptozotocin and its vehicle were injected i.p. into HFD and CD groups, respectively. At the end of the feeding period, rats were euthanised and aortic segments collected for assessment of vascular functional responses and histomorphometry. Tail-cuff systolic blood pressures (154 +/- 6 vs. 110 +/- 4 mmHg) and areas under the curve for oral glucose and i.p. insulin tolerance tests were greater in HFD-D versus CD rats. Abdominal aortic vasoconstriction in response to noradrenaline and KCl was greater in HFD-D compared with CD rats. Thoracic vasoconstrictor responses to noradrenaline, but not KCl, were greater in the HFD-D group. Abdominal, but not thoracic, endothelium-dependent vasorelaxation in response to acetylcholine was blunted in HFD-D relative to CD rats; however, nitric oxide-dependent vasorelaxation in HFD-D rats was impaired in both thoracic and abdominal segments. The abdominal aorta of HFD-D rats showed deranged interlamellar spacing and increased lipid plaque deposition. In conclusion, vascular dysfunction in metabolic syndrome is expressed differentially along the length of the aorta, with the abdominal aorta exhibiting increased susceptibility to vasoconstrictors and greater deficits in endothelium-dependent relaxation. These vascular functional abnormalities could potentially underlie the development of hypertensive cardiovascular disease associated with the metabolic syndrome.
C1 [Ameer, Omar Z.; Salman, Ibrahim M.; Alwadi, Aiman Y.] Alfaisal Univ, Coll Pharm, Riyadh, Saudi Arabia.
   [Ouban, Abderrahman; Abu-Owaimer, Fahmi M.] Alfaisal Univ, Coll Med, Riyadh, Saudi Arabia.
   [AlSharari, Shakir D.] King Saud Univ, Coll Pharm, Riyadh, Saudi Arabia.
   [Bukhari, Ishfaq A.] King Saud Univ, Coll Med, Riyadh, Saudi Arabia.
C3 Alfaisal University; Alfaisal University; King Saud University; King
   Saud University
RP Ameer, OZ (corresponding author), Alfaisal Univ, Coll Pharm, Dept Pharmaceut Sci, Riyadh 11533, Saudi Arabia.
EM oaladhami@alfaisal.edu
RI Alwadi, Aiman/JOJ-4222-2023; Salman, Ibrahim/D-8895-2013; Ameer,
   Omar/D-8915-2013; Ouban, Abderrahman/JYO-5290-2024; AlSharari,
   Shakir/AAC-9103-2020
OI Ameer, Omar/0000-0002-9211-9791; Alwadi, Aiman/0000-0003-2847-8391;
   Salman, Ibrahim/0000-0003-4825-5320; bukhari, ishfaq/0000-0002-5671-2395
FU Alfaisal University, Riyadh, Kingdom of SaudiArabia [2018, 18317]
FX This studywas supported by an internal research grant 2018 (no. 18317)
   from Alfaisal University, Riyadh, Kingdom of SaudiArabia.
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NR 89
TC 6
Z9 6
U1 0
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0958-0670
EI 1469-445X
J9 EXP PHYSIOL
JI Exp. Physiol.
PD MAR
PY 2021
VL 106
IS 3
BP 771
EP 788
DI 10.1113/EP089213
EA JAN 2021
PG 18
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA QO2JW
UT WOS:000612495000001
PM 33450088
OA Bronze
DA 2025-06-11
ER

PT J
AU Godyla-Jablonski, M
   Raczkowska, E
   Jodkowska, A
   Kucharska, AZ
   Sozanski, T
   Bronkowska, M
AF Godyla-Jablonski, Michaela
   Raczkowska, Ewa
   Jodkowska, Anna
   Kucharska, Alicja Zofia
   Sozanski, Tomasz
   Bronkowska, Monika
TI Effects of Anthocyanins on Components of Metabolic Syndrome-A Review
SO NUTRIENTS
LA English
DT Review
DE anthocyanins; bioavailability; metabolic syndrome; obesity;
   dyslipidaemia; hypertension; oxidative stress
ID VACCINIUM-MYRTILLUS L.; FRUITS CORNELIAN CHERRY; C-REACTIVE PROTEIN;
   OXIDATIVE STRESS; INSULIN-RESISTANCE; BLOOD-PRESSURE; DOUBLE-BLIND;
   ANTIOXIDANT PROPERTIES; CHEMICAL-COMPOSITION; CARDIOVASCULAR RISK
AB Metabolic syndrome (MetS) is a significant health problem. The co-occurrence of obesity, carbohydrate metabolism disorders, hypertension and atherogenic dyslipidaemia is estimated to affect 20-30% of adults worldwide. Researchers are seeking solutions to prevent and treat the conditions related to MetS. Preventive medicine, which focuses on modifiable cardiovascular risk factors, including diet, plays a special role. A diet rich in fruits and vegetables has documented health benefits, mainly due to the polyphenolic compounds it contains. Anthocyanins represent a major group of polyphenols; they exhibit anti-atherosclerotic, antihypertensive, antithrombotic, anti-inflammatory and anticancer activities, as well as beneficial effects on endothelial function and oxidative stress. This review presents recent reports on the mechanisms involved in the protective effects of anthocyanins on the body, especially among people with MetS. It includes epidemiological data, in vivo and in vitro preclinical studies and clinical observational studies. Anthocyanins are effective, widely available compounds that can be used in both the prevention and treatment of MetS and its complications. Increased consumption of anthocyanin-rich foods may contribute to the maintenance of normal body weight and modulation of the lipid profile in adults. However, further investigation is needed to confirm the beneficial effects of anthocyanins on serum glucose levels, improvement in insulin sensitivity and reduction in systolic and diastolic blood pressure.
C1 [Godyla-Jablonski, Michaela; Raczkowska, Ewa] Wroclaw Univ Environm & Life Sci, Fac Biotechnol & Food Sci, Dept Human Nutr, Chelmonskiego 37, PL-51630 Wroclaw, Poland.
   [Jodkowska, Anna] Wroclaw Med Univ, Dept Internal Med, Occupat Dis Hypertens & Clin Oncol, Borowska 213, PL-50556 Wroclaw, Poland.
   [Kucharska, Alicja Zofia] Wroclaw Univ Environm & Life Sci, Dept Fruit Vegetable & Plant Nutraceut Technol, Chelmonskiego 37, PL-51630 Wroclaw, Poland.
   [Sozanski, Tomasz] Wroclaw Univ Sci & Technol, Dept Preclin Sci Pharmacol & Med Diag, Wybrzeze Wyspianskiego 27, PL-50370 Wroclaw, Poland.
   [Bronkowska, Monika] Univ Opole, Inst Hlth Sci, Coll Salutis Humanae, Katowicka 68, PL-45060 Opole, Poland.
C3 Wroclaw University of Environmental & Life Sciences; Wroclaw Medical
   University; Wroclaw University of Environmental & Life Sciences; Wroclaw
   University of Science & Technology; University of Opole
RP Raczkowska, E (corresponding author), Wroclaw Univ Environm & Life Sci, Fac Biotechnol & Food Sci, Dept Human Nutr, Chelmonskiego 37, PL-51630 Wroclaw, Poland.
EM michaela.godyla@upwr.edu.pl; ewa.raczkowska@upwr.edu.pl;
   anna.jodkowska@umw.edu.pl; alicja.kucharska@upwr.edu.pl;
   tomasz.sozanski@pwr.edu.pl; monika.bronkowska@uni.opole.pl
RI Kucharska, Alicja/A-1488-2017; Sozanski, Tomasz/NAX-9363-2025;
   Raczkowska, Ewa/S-7720-2016; Bronkowska, Monika/B-3818-2017
OI Godyla-Jablonski, Michaela/0000-0001-5519-711X; Sozanski,
   Tomasz/0000-0003-1722-3190; Raczkowska, Ewa/0000-0003-4205-1351;
   Kucharska, Alicja/0000-0002-2172-0408; Bronkowska,
   Monika/0000-0003-2960-6981
FU Wroclstrok;aw University of Environmental and Life Sciences
FX No Statement Available
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NR 245
TC 7
Z9 7
U1 11
U2 27
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD APR
PY 2024
VL 16
IS 8
AR 1103
DI 10.3390/nu16081103
PG 32
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA OX9Q7
UT WOS:001210698100001
PM 38674794
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Rivoira, MA
   Rigalli, A
   Corball, L
   de Talamoni, NT
   Rodríguez, V
AF Rivoira, Maria A.
   Rigalli, Alfredo
   Corball, Lucia
   Tolosa de Talamoni, Nori
   Rodriguez, Valeria
TI Naringin prevents bone damage in the experimental metabolic syndrome
   induced by a fructose-rich diet
SO APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
LA English
DT Article
DE trabecular bone; cortical bone; naringin; fructose; metabolic syndrome;
   oxidative stress
ID HISTOMORPHOMETRY; ASSOCIATION; WOMEN
AB We analyzed the effect of naringin (NAR), a flavonoid from citric fruits, on bone quality and biomechanical properties, as well as the redox state of bone marrow in rats fed a fructose-rich diet (FRD), an experimental model to mimic human metabolic syndrome. NAR blocked the increase in the number of osteoclasts and adipocytes and the decrease in the number of osteocytes and osteocalcin (+) cells caused by FRD. Trabecular number was significantly higher in the FRD+NAR group. FRD induced a decrease in the femoral trabecular and cortical bone mineral density, which was blocked by NAR. The fracture and ultimate loads were also decreased in the FRD and FRD+NAR groups. NAR increased the number of nodes to terminal trabecula, the number of nodes to node trabecula, the number of nodes, and the number of nodes with 2 terminals and decreased the Dist (mean size of branches) value. FRD decreased bone marrow catalase activity, an effect that was prevented by NAR. In conclusion, FRD has detrimental effects on the long bones, which are associated with oxidative stress in the bone marrow. Most of these changes are prevented by NAR through its antioxidant properties and promotion of bone formation.
   Novelty:
   Fructose-rich diets have detrimental effects on long bones, which are associated with oxidative stress in the bone marrow.
   Most of these changes are prevented by naringin through its antioxidant properties and promotion of bone formation.
C1 [Rivoira, Maria A.; Corball, Lucia; Tolosa de Talamoni, Nori; Rodriguez, Valeria] Univ Nacl Cordoba, Fac Ciencias Med, Lab Dr Fernando Canas, Catedra Bioquim & Biol Mol,INICSA,CONICET, Cordoba, Argentina.
   [Rigalli, Alfredo] UNR, Fac Ciencias Med, Rosario, Argentina.
C3 National University of Cordoba; Consejo Nacional de Investigaciones
   Cientificas y Tecnicas (CONICET); National University of Rosario
RP de Talamoni, NT (corresponding author), Univ Nacl Cordoba, Fac Ciencias Med, Lab Dr Fernando Canas, Catedra Bioquim & Biol Mol,INICSA,CONICET, Cordoba, Argentina.
EM ntolosatalamoni@yahoo.com.ar
OI Rivoira, Maria Angelica/0000-0002-7316-1564
FU FONCYT [PICT-201901003]; CONICET (PIP 2017-2019); SECYT (UNC), Argentina
FX This work was supported by grants from FONCYT (PICT-201901003), CONICET
   (PIP 2017-2019), and SECYT (UNC), Argentina.
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NR 36
TC 6
Z9 6
U1 0
U2 6
PU CANADIAN SCIENCE PUBLISHING
PI OTTAWA
PA 123 Slater Street, Suite 610, OTTAWA, ON K1P 5H2, CANADA
SN 1715-5312
EI 1715-5320
J9 APPL PHYSIOL NUTR ME
JI Appl. Physiol. Nutr. Metab.
PD APR
PY 2022
VL 47
IS 4
BP 395
EP 404
DI 10.1139/apnm-2021-0473
PG 10
WC Nutrition & Dietetics; Physiology; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics; Physiology; Sport Sciences
GA 0J0MI
UT WOS:000779803500005
PM 34890288
DA 2025-06-11
ER

PT J
AU Lakshmi, PK
   Kumar, S
   Pawar, S
   Kuriakose, BB
   Sudheesh, MS
   Pawar, RS
AF Lakshmi, P. K.
   Kumar, Shweta
   Pawar, Sulakshhna
   Kuriakose, Beena Briget
   Sudheesh, M. S.
   Pawar, Rajesh Singh
TI Targeting metabolic syndrome with phytochemicals: Focus on the role of
   molecular chaperones and hormesis in drug discovery
SO PHARMACOLOGICAL RESEARCH
LA English
DT Review
DE Molecular chaperones; Heat shock proteins; Metabolic syndromes;
   Phytochemicals; Herbal; Hormesis; Preconditioning; Metformin; Stress;
   Inflammation
ID HEAT-SHOCK-RESPONSE; CELLULAR STRESS-RESPONSE; INSULIN-RECEPTOR
   SUBSTRATE-1; MILD ELECTRICAL-STIMULATION; GLYCATION END-PRODUCTS;
   PANCREATIC BETA-CELLS; SKELETAL-MUSCLE; OXIDATIVE-METABOLISM;
   ANTIOXIDANT DEFENSE; PROTEIN RESPONSE
AB Adaptive cellular stress response confers stress tolerance against inflammatory and metabolic disorders. In response to metabolic stress, the key mediator of cellular adaptation and tolerance is a class of molecules called the molecular chaperones (MCs). MCs are highly conserved molecules that play critical role in maintaining protein stability and functionality. Hormesis in this context is a unique adaptation mechanism where a low dose of a stressor (which is toxic at high dose) confers a stress-resistant adaptive cellular phenotype. Hormesis can be observed at different level of biological organization at various measurable endpoints. The MCs are believed to play a key role in adaptation during hormesis. Several phytochemicals are known for their hormetic response and are called phytochemical hormetins. The role of phytochemical-mediated hormesis on the adaptive cellular processes is proposed as a potential therapeutic approach to target inflammation associated with metabolic syndrome. However, the screening of phytochemical hormetins would require a paradigm shift in the methods currently used in drug discovery.
C1 [Lakshmi, P. K.; Kumar, Shweta] VNS Grp Inst, Pharmacognosy & Phytochem Lab, Fac Pharm, VNS Campus, Bhopal 462044, MP, India.
   [Pawar, Sulakshhna] Ravi Shankar Coll Pharm, Bypass Rd,Bhanpur Sq, Bhopal 462010, MP, India.
   [Kuriakose, Beena Briget] King Khalid Univ, Dept Basic Med Sci, Coll Appl Med Sci, Khamis, Mushayt, Saudi Arabia.
   [Sudheesh, M. S.] Amrita Vishwa Vidyapeetham, Amrita Sch Pharm, Dept Pharmaceut, Amrita Hlth Sci Campus, Kochi 682041, India.
   [Pawar, Rajesh Singh] Truba Inst Pharm, Pass Rd, Bhopal 462038, India.
C3 King Khalid University; Amrita Vishwa Vidyapeetham; Amrita Vishwa
   Vidyapeetham Kochi
RP Pawar, RS (corresponding author), Truba Inst Pharm, Pass Rd, Bhopal 462038, India.
EM dr_pawar14@rediffmail.com
RI Pawar, Rajesh/AAW-7206-2021
OI Pawar, Rajesh Singh/0000-0002-7388-8755
FU MP council for science and technology (MPCST), Bhopal, M.P., India
   [A/RD/RP/-2/2014-15/04]
FX The authors RSP and LPK are thankful to MP council for science and
   technology (MPCST), Bhopal, M.P., India (A/RD/RP/-2/2014-15/04) for
   financial support and Jayasankar PK for figure composition. The
   suggestions of the editor and the reviewers are gratefully acknowledged.
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NR 129
TC 8
Z9 8
U1 2
U2 17
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 1043-6618
J9 PHARMACOL RES
JI Pharmacol. Res.
PD SEP
PY 2020
VL 159
AR 104925
DI 10.1016/j.phrs.2020.104925
PG 13
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA NK0LW
UT WOS:000566434200011
PM 32492491
DA 2025-06-11
ER

PT J
AU Gavia-García, G
   Rosado-Pérez, J
   Aguiñiga-Sánchez, I
   Santiago-Osorio, E
   Mendoza-Núñez, VM
AF Gavia-Garcia, Graciela
   Rosado-Perez, Juana
   Aguiniga-Sanchez, Itzen
   Santiago-Osorio, Edelmiro
   Manuel Mendoza-Nunez, Victor
TI Effect ofSechium edulevar.nigrum spinosum(Chayote) on
   Telomerase Levels and Antioxidant Capacity in Older Adults with
   Metabolic Syndrome
SO ANTIOXIDANTS
LA English
DT Article
DE metabolic syndrome; telomerase; oxidative stress; antioxidants; ageing;
   S; edule
ID DNA-DAMAGE; OXIDATIVE STRESS; ASSOCIATION; ENZYMES; OBESITY
AB Patients with metabolic syndrome (MetS) have a redox imbalance, due to a decay in antioxidant capacity. Oxidative stress (OxS) is considered an important modulator of telomere shortening and telomerase activity. One of the fruits that has been associated with an antioxidant effect isSechium eduleand although its properties are well established, there is only one exploratory study evaluating its effectiveness in patients with MetS. The present investigation is a much more robust and controlled study, including a placebo group. Hence, we determined the effect of consumption of the dried fruit powder (500 mg, three times per day) for three months. We measured effects on telomerase levels, antioxidant capacity, and markers for OxS. The study was performed in a sample of 75 older adults: placebo group (n= 30) and experimental group (n= 45) with the diagnosis of MetS according to the National Adult Treatment Panel of the National Cholesterol Program III (NCEP/ATP III) criteria. All markers were measured before and after three months of treatment. There was a statistically significant decrease in lipoperoxides and protein carbonylation with an increased superoxide dismutase (SOD), as well as sustained levels of telomerase in patients who consumedSechium edule. Our findings suggest that consumption of this fruit has a hypoglycemic, hypotensive, and antioxidant effect, without altering telomerase levels, which could suggest better protection against telomere shortening.
C1 [Gavia-Garcia, Graciela; Rosado-Perez, Juana; Manuel Mendoza-Nunez, Victor] Univ Nacl Autonoma Mexico, Res Unit Gerontol, FES Zaragoza, Mexico City 09230, DF, Mexico.
   [Aguiniga-Sanchez, Itzen; Santiago-Osorio, Edelmiro] Univ Nacl Autonoma Mexico, Res Unit Cell Differentiat & Canc, Hematopoiesis & Leukemia Lab, FES Zaragoza, Mexico City 09230, DF, Mexico.
C3 Universidad Nacional Autonoma de Mexico; Universidad Nacional Autonoma
   de Mexico
RP Mendoza-Núñez, VM (corresponding author), Univ Nacl Autonoma Mexico, Res Unit Gerontol, FES Zaragoza, Mexico City 09230, DF, Mexico.
EM ggg1501@hotmail.com; juanarosadoperez@comunidad.unam.mx;
   itzen.aguiniga@zaragoza.unam.mx; edelmiro@unam.mx; mendovic@unam.mx
RI Mendoza-Núñez, Víctor Manuel/AFL-2465-2022
OI Santiago-Osorio, Edelmiro/0000-0002-4876-0688; Aguiniga-Sanchez,
   Itzen/0000-0003-1692-8287
FU General Directorate of Academic Personnel Affairs, National Autonomous
   University of Mexico (DGAPA-UNAM); Secretariat of Science [PAPIIT
   IN218718]; Technology and Innovation Project of Mexico City (SECITI)
   [SECITI/045/2018]
FX This work was supported by grants from the General Directorate of
   Academic Personnel Affairs, National Autonomous University of Mexico
   (DGAPA-UNAM), and the Secretariat of Science (PAPIIT IN218718), and the
   Technology and Innovation Project of Mexico City (SECITI)
   (SECITI/045/2018).
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NR 58
TC 5
Z9 5
U1 2
U2 4
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD JUL
PY 2020
VL 9
IS 7
AR 634
DI 10.3390/antiox9070634
PG 14
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA MS3NI
UT WOS:000554186900001
PM 32708368
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Vartanian, V
   Lowell, B
   Minko, IG
   Wood, TG
   Ceci, JD
   George, S
   Ballinger, SW
   Corless, CL
   McCullough, AK
   Lloyd, RS
AF Vartanian, V
   Lowell, B
   Minko, IG
   Wood, TG
   Ceci, JD
   George, S
   Ballinger, SW
   Corless, CL
   McCullough, AK
   Lloyd, RS
TI The metabolic syndrome resulting from a knockout of the NEIL1 DNA
   glycosylase
SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF
   AMERICA
LA English
DT Article
DE DNA repair; fatty liver disease; mitochondria; obesity; oxidative stress
ID HUMAN 8-OXOGUANINE GLYCOSYLASE; BASE-EXCISION-REPAIR; OXIDATIVE STRESS;
   DAMAGE; OBESITY; MECHANISMS; ENZYME; IDENTIFICATION; MITOCHONDRIA;
   INDUCTION
AB Endogenously formed reactive oxygen species continuously damage cellular constituents including DNA. These challenges, coupled with exogenous exposure to agents that generate reactive oxygen species, are both associated with normal aging processes and linked to cardiovascular disease, cancer, cataract formation, and fatty liver disease. Although not all of these diseases have been definitively shown to originate from mutations in nuclear DNA or mitochondrial DNA, repair of oxidized, saturated, and ring-fragmented bases via the base excision repair pathway is known to be critical for maintaining genomic stability. One enzyme that initiates base excision repair of ring-fragmented purines and some saturated pyrimidines is NEIL1, a mammalian homolog to Escherichia coli endonuclease VIII. To investigate the organismal consequences of a deficiency in NEIL1, a knockout mouse model was created. In the absence of exogenous oxidative stress, neil1 knockout (neil1(-/-)) and heterozygotic (neil1(+/-)) mice develop severe obesity, dyslipidemia, and fatty liver disease and also have a tendency to develop hyperinsulinemia. in humans, this combination of clinical manifestations, including hypertension, is known as the metabolic syndrome and is estimated to affect > 40 million people in the United States. Additionally, mitochondrial DNA from neil1(-/-) mice show increased levels of steady-state DNA damage and deletions relative to wild-type controls. These data suggest an important role for NEIL1 in the prevention of the diseases associated with the metabolic syndrome.
C1 Oregon Hlth & Sci Univ, Ctr Res Occupat & Environm Toxicol, Portland, OR 97239 USA.
   Oregon Hlth & Sci Univ, Dept Mol & Med Genet, Portland, OR 97239 USA.
   Univ Texas, Med Branch, Dept Biochem & Mol Biol, Galveston, TX 77555 USA.
   Univ Alabama Birmingham, Dept Pathol, Birmingham, AL 35294 USA.
   Oregon Hlth & Sci Univ, Dept Pathol, Portland, OR 97239 USA.
   Oregon Hlth & Sci Univ, Oregon Canc Inst, Portland, OR 97239 USA.
C3 Oregon Health & Science University; Oregon Health & Science University;
   University of Texas System; University of Texas Medical Branch
   Galveston; University of Alabama System; University of Alabama
   Birmingham; Oregon Health & Science University; Oregon Health & Science
   University
RP Oregon Hlth & Sci Univ, Ctr Res Occupat & Environm Toxicol, 2598 CROET Bldg,3181 SW Sam Jackson Pk Rd, Portland, OR 97239 USA.
EM lloydst@ohsu.edu
RI Wood, Thomas/B-6172-2012
OI Lloyd, R. Stephen/0000-0001-7273-372X
FU NIDDK NIH HHS [R01 DK075974] Funding Source: Medline
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NR 36
TC 207
Z9 227
U1 0
U2 11
PU NATL ACAD SCIENCES
PI WASHINGTON
PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA
SN 0027-8424
J9 P NATL ACAD SCI USA
JI Proc. Natl. Acad. Sci. U. S. A.
PD FEB 7
PY 2006
VL 103
IS 6
BP 1864
EP 1869
DI 10.1073/pnas.0507444103
PG 6
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 012AT
UT WOS:000235311300037
PM 16446448
OA Green Published
DA 2025-06-11
ER

PT J
AU Jia, GH
   Aroor, AR
   Martinez-Lemus, LA
   Sowers, JR
AF Jia, Guanghong
   Aroor, Annayya R.
   Martinez-Lemus, Luis A.
   Sowers, James R.
TI Overnutrition, mTOR signaling, and cardiovascular diseases
SO AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE
   PHYSIOLOGY
LA English
DT Review
DE cardiorenal metabolic syndrome; cardiovascular disease; insulin
   resistance; mammalian target of rapamycin; obesity
ID REGULATORY T-CELLS; MAMMALIAN TARGET; RAPAMYCIN MTOR;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; OXIDATIVE-STRESS;
   CARDIAC-FUNCTION; POTENTIAL-ROLE; URIC-ACID; AUTOPHAGY
AB The prevalence of obesity and associated medical disorders has increased dramatically in the United States and throughout much of the world in the past decade. Obesity, induced by excess intake of carbohydrates and fats, is a major cause of Type 2 diabetes, hypertension, and the cardiorenal metabolic syndrome. There is emerging evidence that excessive nutrient intake promotes signaling through the mammalian target of rapamycin (mTOR), which, in turn, may lead to alterations of cellular metabolic signaling leading to insulin resistance and obesity-related diseases, such as diabetes, cardiovascular and kidney disease, as well as cancer. While the pivotal role of mTOR signaling in regulating metabolic stress, autophagy, and adaptive immune responses has received increasing attention, there remain many gaps in our knowledge regarding this important nutrient sensor. For example, the precise cellular signaling mechanisms linking excessive nutrient intake and enhanced mTOR signaling with increased cardiovascular and kidney disease, as well as cancer, are not well understood. In this review, we focus on the effects that the interaction between excess intake of nutrients and enhanced mTOR signaling have on the promotion of obesity-associated diseases and potential therapeutic strategies involving targeting mTOR signaling.
C1 [Jia, Guanghong; Aroor, Annayya R.; Sowers, James R.] Univ Missouri, Sch Med, Diabet Cardiovasc Ctr, Div Endocrinol, Columbia, MO 65212 USA.
   [Jia, Guanghong; Aroor, Annayya R.; Sowers, James R.] Univ Missouri, Sch Med, Diabet Cardiovasc Ctr, Div Diabet, Columbia, MO 65212 USA.
   [Jia, Guanghong; Aroor, Annayya R.; Sowers, James R.] Univ Missouri, Sch Med, Diabet Cardiovasc Ctr, Div Hypertens, Columbia, MO 65212 USA.
   [Jia, Guanghong; Aroor, Annayya R.; Sowers, James R.] Univ Missouri, Sch Med, Diabet Cardiovasc Ctr, Div Metab, Columbia, MO 65212 USA.
   [Martinez-Lemus, Luis A.; Sowers, James R.] Univ Missouri, Sch Med, Dept Med Pharmacol, Columbia, MO 65212 USA.
   [Martinez-Lemus, Luis A.; Sowers, James R.] Univ Missouri, Sch Med, Dept Physiol, Columbia, MO 65212 USA.
   [Jia, Guanghong; Aroor, Annayya R.; Martinez-Lemus, Luis A.; Sowers, James R.] Univ Missouri, Sch Med, Harry S Truman Mem Vet Hosp, Columbia, MO 65212 USA.
   [Martinez-Lemus, Luis A.; Sowers, James R.] Univ Missouri, Sch Med, Dalton Cardiovasc Res Ctr, Columbia, MO 65212 USA.
C3 University of Missouri System; University of Missouri Columbia;
   University of Missouri System; University of Missouri Columbia;
   University of Missouri System; University of Missouri Columbia;
   University of Missouri System; University of Missouri Columbia;
   University of Missouri System; University of Missouri Columbia;
   University of Missouri System; University of Missouri Columbia; US
   Department of Veterans Affairs; Veterans Health Administration (VHA);
   Harry S. Truman Memorial Veterans' Hospital; University of Missouri
   System; University of Missouri Columbia; University of Missouri System;
   University of Missouri Columbia
RP Sowers, JR (corresponding author), Univ Missouri, D109 Diabet Ctr HSC,One Hosp Dr, Columbia, MO 65212 USA.
EM sowersj@health.missouri.edu
FU National Institutes of Health [R01 HL73101-01A, R01 HL107910-01];
   Veterans Affairs Merit System [0018]
FX The authors would like to thank Brenda Hunter for her editorial
   assistance. This research was supported by National Institutes of Health
   (R01 HL73101-01A, R01 HL107910-01) and the Veterans Affairs Merit System
   (0018) for J. R. Sowers.
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NR 98
TC 95
Z9 104
U1 1
U2 26
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0363-6119
EI 1522-1490
J9 AM J PHYSIOL-REG I
JI Am. J. Physiol.-Regul. Integr. Comp. Physiol.
PD NOV 15
PY 2014
VL 307
IS 10
BP R1198
EP R1206
DI 10.1152/ajpregu.00262.2014
PG 9
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA AT9LW
UT WOS:000345249800002
PM 25253086
OA Green Published
DA 2025-06-11
ER

PT J
AU Ambrosini, S
   Mohammed, SA
   Lüscher, TF
   Costantino, S
   Paneni, F
AF Ambrosini, Samuele
   Mohammed, Shafeeq A.
   Luescher, Thomas F.
   Costantino, Sarah
   Paneni, Francesco
TI New Mechanisms of Vascular Dysfunction in Cardiometabolic Patients:
   Focus on Epigenetics
SO HIGH BLOOD PRESSURE & CARDIOVASCULAR PREVENTION
LA English
DT Review
DE Epigenetics; Metabolic syndrome; Cardiovascular disease; Endothelial
   dysfunction
ID EPIGENOME-WIDE ASSOCIATION; HISTONE DEACETYLASE 3; LONG NONCODING RNAS;
   OXIDATIVE STRESS; DNA METHYLATION; GENE-EXPRESSION; ADIPOSE-TISSUE;
   MITOCHONDRIAL-FUNCTION; PROMOTER METHYLATION; METABOLIC SYNDROME
AB Epigenetic processing takes centre stage in cardiometabolic diseases (obesity, metabolic syndrome, type 2 diabetes, hypertension), where it participates in adiposity, inflammation, endothelial dysfunction, vascular insulin resistance and atherosclerosis. Epigenetic modifications, defined as heritable changes in gene expression that do not entail mutation in the DNA sequence, are mainly induced by environmental stimuli (stress, pollution, cigarette smoking) and are gaining considerable interest due to their causal role in cardiovascular disease, and their amenability to pharmacological intervention. Importantly, epigenetic modifications acquired during life can be transmitted to the offspring and exert their biological effects across multiple generations. Indeed, such transgenerational transmission of epigenetic signals may contribute to anticipating cardiovascular and metabolic disease phenotypes already in children and young adults. A deeper understanding of environmental factors and their effects on the epigenetic machinery and transcriptional programs is warranted to develop effective mechanism-based therapeutic strategies. The clinical application of epigenetic drugs-also known as "epi-drugs"-is currently exploding in the field of cardiovascular disease. The present review describes the main epigenetic networks underlying cardiometabolic alterations and sheds light on specific points of intervention for pharmacological reprogramming in this setting.
C1 [Ambrosini, Samuele; Mohammed, Shafeeq A.; Luescher, Thomas F.; Costantino, Sarah; Paneni, Francesco] Univ Zurich, Ctr Mol Cardiol, Wagistr 12, CH-8952 Schlieren, Switzerland.
   [Luescher, Thomas F.] Royal Brompton & Harefield Hosp Trust, Cardiol, London SW3 6NP, England.
   [Luescher, Thomas F.] Imperial Coll London, London SW3 6NP, England.
   [Paneni, Francesco] Univ Hosp Zurich, Univ Heart Ctr, Cardiol, Zurich, Switzerland.
   [Paneni, Francesco] Univ Hosp Zurich, Dept Res & Educ, Zurich, Switzerland.
C3 Royal Brompton & Harefield NHS Foundation Trust; Harefield Hospital;
   Imperial College London; University of Zurich; University Zurich
   Hospital; University of Zurich; University Zurich Hospital
RP Paneni, F (corresponding author), Univ Zurich, Ctr Mol Cardiol, Wagistr 12, CH-8952 Schlieren, Switzerland.
EM francesco.paneni@uzh.ch
RI Costantino, Sarah/ABD-7708-2020; mohammed, shafeeq ahmed/HLH-6073-2023
OI Paneni, Francesco/0000-0001-6483-7844; Mohammed, Shafeeq
   A./0000-0003-2365-5037; Costantino, Sarah/0000-0002-3003-7213;
   Ambrosini, Samuele/0000-0002-2112-1122
FU Zurich Heart House; Swiss Heart Foundation; Swiss Life Foundation; EMDO
   Stiftung; Schweizerische Diabetes-Stiftung; Holcim Foundation; Kurt und
   Senta-Hermann Stiftung; Olga-Mayenfish Stiftung; H.H. Sheikh Khalifa bin
   Hamad Al Thani Foundation Assistant Professorship at the Faculty of
   Medicine, University of Zurich; MRC [MC_PC_19009] Funding Source: UKRI
FX FP is the recipient of a H.H. Sheikh Khalifa bin Hamad Al Thani
   Foundation Assistant Professorship at the Faculty of Medicine,
   University of Zurich. This work was supported by the Zurich Heart House,
   the Swiss Heart Foundation, Swiss Life Foundation, Kurt und
   Senta-Hermann Stiftung, the EMDO Stiftung, the Schweizerische
   Diabetes-Stiftung, the Olga-Mayenfish Stiftung (to FP); the Holcim
   Foundation and the Swiss Heart Foundation (to SC).
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NR 95
TC 14
Z9 15
U1 0
U2 8
PU ADIS INT LTD
PI NORTHCOTE
PA 5 THE WAREHOUSE WAY, NORTHCOTE 0627, AUCKLAND, NEW ZEALAND
SN 1120-9879
EI 1179-1985
J9 HIGH BLOOD PRESS CAR
JI High Blood Press. Cardiovasc. Prevent.
PD OCT
PY 2020
VL 27
IS 5
BP 363
EP 371
DI 10.1007/s40292-020-00400-2
EA AUG 2020
PG 9
WC Peripheral Vascular Disease
WE Emerging Sources Citation Index (ESCI)
SC Cardiovascular System & Cardiology
GA NX6WW
UT WOS:000554419700001
PM 32740853
DA 2025-06-11
ER

PT J
AU Cano-Ibáñez, N
   Serra-Majem, L
   Martín-Peláez, S
   Martínez-González, MA
   Salas-Salvadó, J
   Corella, D
   Lassale, C
   Martínez, JA
   Alonso-Gómez, AM
   Wärnberg, J
   Vioque, J
   Romaguera, D
   López-Miranda, J
   Estruch, R
   Gómez-Pérez, AM
   Lapetra, J
   Fernández-Aranda, F
   Bueno-Cavanillas, A
   Tur, JA
   Cubelos, N
   Pintó, X
   Gaforio, JJ
   Matía-Martín, P
   Vidal, J
   Calderón, C
   Daimiel, L
   Ros, E
   Gea, A
   Babio, N
   Gimenez-Alba, IM
   Zomeño-Fajardo, MD
   Abete, I
   Sierra, LT
   Romero-Galisteo, RP
   de la Hera, MG
   Martín-Padillo, M
   García-Ríos, A
   Casas, RM
   Fernández-García, JC
   Santos-Lozano, JM
   Toledo, E
   Becerra-Tomas, N
   Sorli, J
   Schröder, H
   Zulet, MA
   Sorto-Sánchez, C
   Diez-Espino, J
   Gómez-Martínez, C
   Fitó, M
   Sánchez-Villegas, A
AF Cano-Ibanez, Naomi
   Serra-Majem, Lluis
   Martin-Pelaez, Sandra
   Angel Martinez-Gonzalez, Miguel
   Salas-Salvado, Jordi
   Corella, Dolores
   Lassale, Camille
   Alfredo Martinez, Jose
   Alonso-Gomez, Angel M.
   Warnberg, Julia
   Vioque, Jesus
   Romaguera, Dora
   Lopez-Miranda, Jose
   Estruch, Ramon
   Maria Gomez-Perez, Ana
   Lapetra, Jose
   Fernandez-Aranda, Fernando
   Bueno-Cavanillas, Aurora
   Tur, Josep A.
   Cubelos, Naiara
   Pinto, Xavier
   Gaforio, Jose Juan
   Matia-Martin, Pilar
   Vidal, Josep
   Calderon, Cristina
   Daimiel, Lidia
   Ros, Emilio
   Gea, Alfredo
   Babio, Nancy
   Manuel Gimenez-Alba, Ignacio
   Dolores Zomeno-Fajardo, Maria
   Abete, Itziar
   Tojal Sierra, Lucas
   Romero-Galisteo, Rita P.
   Garcia de la Hera, Manoli
   Martin-Padillo, Marian
   Garcia-Rios, Antonio
   Casas, Rosa M.
   Fernandez-Garcia, J. C.
   Manuel Santos-Lozano, Jose
   Toledo, Estefania
   Becerra-Tomas, Nerea
   Sorli, Jose, V
   Schroder, Helmut
   Zulet, Maria A.
   Sorto-Sanchez, Carolina
   Diez-Espino, Javier
   Gomez-Martinez, Carlos
   Fito, Montse
   Sanchez-Villegas, Almudena
TI Dietary diversity and depression: cross-sectional and longitudinal
   analyses in Spanish adult population with metabolic syndrome. Findings
   from PREDIMED-Plus trial
SO PUBLIC HEALTH NUTRITION
LA English
DT Article
DE Dietary diversity score; Depression; PREDIMED-Plus study
ID PHYSICAL-ACTIVITY QUESTIONNAIRE; FOOD FREQUENCY QUESTIONNAIRE;
   NATIONAL-HEALTH; RISK; VALIDATION; QUALITY; METAANALYSIS; CONSUMPTION;
   PREVALENCE; SYMPTOMS
AB Objective: To examine the cross-sectional and longitudinal (2-year follow-up) associations between dietary diversity (DD) and depressive symptoms. Design: An energy-adjusted dietary diversity score (DDS) was assessed using a validated FFQ and was categorised into quartiles (Q). The variety in each food group was classified into four categories of diversity (C). Depressive symptoms were assessed with Beck Depression Inventory-II (Beck II) questionnaire and depression cases defined as physician-diagnosed or Beck II >= 18. Linear and logistic regression models were used. Setting: Spanish older adults with metabolic syndrome (MetS). Participants: A total of 6625 adults aged 55-75 years from the PREDIMED-Plus study with overweight or obesity and MetS. Results: Total DDS was inversely and statistically significantly associated with depression in the cross-sectional analysis conducted; OR Q4 v. Q1 = 0 center dot 76 (95 % CI (0 center dot 64, 0 center dot 90)). This was driven by high diversity compared to low diversity (C3 v. C1) of vegetables (OR = 0 center dot 75, 95 % CI (0 center dot 57, 0 center dot 93)), cereals (OR = 0 center dot 72 (95 % CI (0 center dot 56, 0 center dot 94)) and proteins (OR = 0 center dot 27, 95 % CI (0 center dot 11, 0 center dot 62)). In the longitudinal analysis, there was no significant association between the baseline DDS and changes in depressive symptoms after 2 years of follow-up, except for DD in vegetables C4 v. C1 = (beta = 0 center dot 70, 95 % CI (0 center dot 05, 1 center dot 35)). Conclusions: According to our results, DD is inversely associated with depressive symptoms, but eating more diverse does not seem to reduce the risk of future depression. Additional longitudinal studies (with longer follow-up) are needed to confirm these findings.
C1 [Cano-Ibanez, Naomi; Martin-Pelaez, Sandra; Bueno-Cavanillas, Aurora] Univ Granada, Fac Med, Dept Prevent Med & Publ Hlth, Avda Invest 11, Granada 18016, Spain.
   [Cano-Ibanez, Naomi; Vioque, Jesus; Bueno-Cavanillas, Aurora; Gaforio, Jose Juan; Garcia de la Hera, Manoli; Schroder, Helmut] Inst Hlth Carlos III, Ctr Invest Biomed Red Epidemiol & Salud Publ CIBE, Madrid, Spain.
   [Cano-Ibanez, Naomi; Martin-Pelaez, Sandra; Bueno-Cavanillas, Aurora] Inst Invest Biosanitaria Granada Ibs GRANADA, Granada, Spain.
   [Serra-Majem, Lluis; Angel Martinez-Gonzalez, Miguel; Salas-Salvado, Jordi; Corella, Dolores; Lassale, Camille; Alfredo Martinez, Jose; Alonso-Gomez, Angel M.; Warnberg, Julia; Romaguera, Dora; Lopez-Miranda, Jose; Estruch, Ramon; Maria Gomez-Perez, Ana; Lapetra, Jose; Fernandez-Aranda, Fernando; Tur, Josep A.; Pinto, Xavier; Ros, Emilio; Gea, Alfredo; Babio, Nancy; Manuel Gimenez-Alba, Ignacio; Dolores Zomeno-Fajardo, Maria; Tojal Sierra, Lucas; Martin-Padillo, Marian; Garcia-Rios, Antonio; Casas, Rosa M.; Fernandez-Garcia, J. C.; Manuel Santos-Lozano, Jose; Toledo, Estefania; Becerra-Tomas, Nerea; Sorli, Jose, V; Zulet, Maria A.; Sorto-Sanchez, Carolina; Diez-Espino, Javier; Gomez-Martinez, Carlos; Fito, Montse; Sanchez-Villegas, Almudena] Inst Salud Carlos III ISCIII, MP Fisiopatol Obesidad & Nutr CIBERObn, Consorcio CIBER, Madrid, Spain.
   [Serra-Majem, Lluis; Fernandez-Aranda, Fernando; Sanchez-Villegas, Almudena] Univ Las Palmas Gran Canaria, Res Inst Biomed & Hlth Sci IUIBS, Las Palmas Gran Canaria, Spain.
   [Angel Martinez-Gonzalez, Miguel; Gea, Alfredo; Abete, Itziar; Toledo, Estefania; Zulet, Maria A.; Diez-Espino, Javier] Univ Navarra, Dept Prevent Med & Publ Hlth, IDISNA, Pamplona, Spain.
   [Angel Martinez-Gonzalez, Miguel] Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA.
   [Salas-Salvado, Jordi; Babio, Nancy; Becerra-Tomas, Nerea; Gomez-Martinez, Carlos] Univ Rovira & Virgili, Dept Bioquim & Biotecnol, Unitat Nutricio Humana, Reus, Spain.
   [Salas-Salvado, Jordi; Babio, Nancy] Univ Hosp St Joan de Reus, Nutr Unit, Reus, Spain.
   [Salas-Salvado, Jordi; Babio, Nancy; Becerra-Tomas, Nerea; Gomez-Martinez, Carlos] Inst Invest Sanitaria Pere Virgili IISPV, Reus, Spain.
   [Corella, Dolores; Manuel Gimenez-Alba, Ignacio; Sorli, Jose, V] Univ Valencia, Dept Prevent Med, Valencia, Spain.
   [Lassale, Camille; Dolores Zomeno-Fajardo, Maria; Schroder, Helmut; Fito, Montse] Inst Hosp Mar Invest Med Municipal Invest Med IMI, Unit Cardiovasc Risk & Nutr, Barcelona, Spain.
   [Alfredo Martinez, Jose; Abete, Itziar; Zulet, Maria A.] Univ Navarra, Ctr Nutr Res, Dept Nutr Food Sci & Physiol, Pamplona, Spain.
   [Alfredo Martinez, Jose] CEI UAM CSIC, IMDEA Food, Cardiometab Nutr Grp, Madrid, Spain.
   [Alonso-Gomez, Angel M.; Tojal Sierra, Lucas; Sorto-Sanchez, Carolina] Bioaraba Hlth Res Inst, Cardiovasc Resp & Metab Area, Vitoria, Spain.
   [Alonso-Gomez, Angel M.; Tojal Sierra, Lucas; Sorto-Sanchez, Carolina] Univ Basque Country, UPV EHU, Araba Univ Hosp, Osakidetza Basque Hlth Serv, Vitoria, Spain.
   [Warnberg, Julia; Romero-Galisteo, Rita P.] Univ Malaga, Sch Hlth Sci, Inst Invest Biomed Malaga IBIMA, Dept Nursing, Malaga, Spain.
   [Vioque, Jesus] Univ Miguel Hernandez ISABIAL UMH, Inst Invest Sanitaria & Biomed Alicante, Nutr Epidemiol Unit, Alicante, Spain.
   [Romaguera, Dora; Martin-Padillo, Marian] Hlth Res Inst Balearic Isl IdISBa, Palma De Mallorca, Spain.
   [Lopez-Miranda, Jose; Garcia-Rios, Antonio] Univ Cordoba, Reina Sofia Univ Hosp, Maimonides Biomed Res Inst Cordoba IMIBIC, Lipids & Atherosclerosis Unit,Dept Internal Med, Cordoba, Spain.
   [Estruch, Ramon; Casas, Rosa M.] Univ Barcelona, Hosp Clin, Inst Invest Biomed August Pi Sunyer IDIBAPS, Dept Internal Med, Barcelona, Spain.
   [Maria Gomez-Perez, Ana; Fernandez-Garcia, J. C.] Univ Malaga, Virgen de la Victoria Hosp, Inst Invest Biomed Malga IBIMA, Dept Endocrinol, Malaga, Spain.
   [Lapetra, Jose; Manuel Santos-Lozano, Jose] Dist Sanitario Atenc Primaria Sevilla, Res Unit, Dept Family Med, Seville, Spain.
   [Tur, Josep A.] Univ Balearic Isl, Res Grp Community Nutr & Oxidat Stress, Palma De Mallorca, Spain.
   [Cubelos, Naiara] Univ Leon, Jose Aguado Hlth Ctr, Inst Biomed IBIOMED, Leon, Spain.
   [Pinto, Xavier] Hosp Univ Bellvitge, Lipids & Vasc Risk Unit, Internal Med, Barcelona, Spain.
   [Gaforio, Jose Juan] Univ Jaen, Ctr Adv Studies Olive Grove & Olive Oils, Jaen, Spain.
   [Matia-Martin, Pilar] Inst Invest Sanitaria Hosp Clin San Carlos IdISSC, Dept Endocrinol & Nutr, Madrid, Spain.
   [Vidal, Josep] Inst Salud Carlos III ISCIII, CIBER Diabet & Enfermedades Metab CIBERDEM, Madrid, Spain.
   [Vidal, Josep; Ros, Emilio] Univ Barcelona, Hosp Clin, Inst Invest Biomed August Pi Sunyer IDIBAPS, Dept Endocrinol, Barcelona, Spain.
   [Calderon, Cristina] Univ Autonoma, Hosp Fdn Jimenez Diaz, Inst Invest Biomed IISFJD, Dept Endocrinol & Nutr, Madrid, Spain.
   [Daimiel, Lidia] CEI UAM CSIC, IMDEA Food, Precis Nutr & Obes Program, Nutr Control Epigenome Grp, Madrid, Spain.
   [Garcia de la Hera, Manoli] Miguel Hernandez Univ, Nutr Epidemiol Unit, ISABIAL FISABIO, Alicante, Spain.
   [Diez-Espino, Javier] Inst Invest Sanitaria Navarra IdiSNA, Serv Navarro Salud Osasunbidea, Navarra, Spain.
C3 University of Granada; CIBER - Centro de Investigacion Biomedica en Red;
   CIBERESP; Instituto de Investigacion Biosanitaria IBS Granada;
   Universidad de Las Palmas de Gran Canaria; University of Navarra;
   Harvard University; Harvard T.H. Chan School of Public Health;
   Universitat Rovira i Virgili; Universitat Rovira i Virgili; Institut
   d'Investigacio Sanitaria Pere Virgili (IISPV); University of Valencia;
   University of Navarra; IMDEA Food Institute; Consejo Superior de
   Investigaciones Cientificas (CSIC); Bioaraba Health Research Institute;
   University Hospital of Araba; University of Basque Country; Instituto de
   Investigacion Biomedica de Malaga y Plataforma en Nanomedicina (IBIMA);
   Universidad de Malaga; General University Hospital of Alicante;
   Universidad Miguel Hernandez de Elche; Universitat d'Alacant; Instituto
   de Investigacion Sanitaria y Biomedica de Alicante (ISABIAL); Institut
   Investigacio Sanitaria Illes Balears (IdISBa); Universidad de Cordoba;
   University of Barcelona; Hospital Clinic de Barcelona; IDIBAPS;
   Instituto de Investigacion Biomedica de Malaga y Plataforma en
   Nanomedicina (IBIMA); Universidad de Malaga; Universitat de les Illes
   Balears; Universidad de Leon; University of Barcelona; Institut
   d'Investigacio Biomedica de Bellvitge (IDIBELL); Bellvitge University
   Hospital; Universidad de Jaen; CIBER - Centro de Investigacion Biomedica
   en Red; CIBERDEM; University of Barcelona; Hospital Clinic de Barcelona;
   IDIBAPS; Autonomous University of Madrid; Fundacion Jimenez Diaz;
   Consejo Superior de Investigaciones Cientificas (CSIC); IMDEA Food
   Institute; General University Hospital of Alicante; Universidad Miguel
   Hernandez de Elche; Universitat d'Alacant; Instituto de Investigacion
   Sanitaria y Biomedica de Alicante (ISABIAL); Servicio Navarro de Salud -
   Osasunbidea
RP Cano-Ibáñez, N (corresponding author), Univ Granada, Fac Med, Dept Prevent Med & Publ Hlth, Avda Invest 11, Granada 18016, Spain.; Cano-Ibáñez, N (corresponding author), Inst Hlth Carlos III, Ctr Invest Biomed Red Epidemiol & Salud Publ CIBE, Madrid, Spain.; Cano-Ibáñez, N (corresponding author), Inst Invest Biosanitaria Granada Ibs GRANADA, Granada, Spain.
EM ncaiba@ugr.es
RI Abad-Gurumeta, Alfredo/M-2337-2019; Romero-Galisteo, Rita/Z-1976-2018;
   Corella, Dolores/L-9888-2014; Alba, Ignacio/ABI-4663-2020;
   Martinez-Gonzalez, Miguel/AAE-7669-2019; Babio, Nancy/AAN-2715-2020;
   Estruch, Ramon/AAZ-3723-2020; Fernandez-Garcia, Jose/B-5312-2013;
   Lapetra, Jose/F-2552-2015; ALONSO GOMEZ, ANGEL/HLG-2476-2023; Martinez,
   Sandra/HSG-4592-2023; Vidal, Josep/MIK-6936-2025; Serra-Majem,
   Lluis/I-6708-2019; Warnberg, Julia/G-1390-2011; Romaguera,
   Dora/ABE-7004-2020; Lopez-Miranda, Jose/Y-8306-2019; Sorlí,
   José/L-8758-2014; Tejada, Silvia/L-7297-2014; Pintó,
   Xavier/AGI-4297-2022; Lassale, Camille/ABE-7813-2020; Martinez,
   Juan/GXM-4393-2022; MARTIN-PELAEZ, SANDRA/G-4945-2015; Tur,
   Josep/AAE-5748-2020; Bueno-Cavanillas, Aurora/O-1513-2015; Toledo,
   Estefania/H-6211-2014; Casas, Rosa/ABD-1915-2020; Daimiel-Ruiz,
   Lidia/M-7779-2014; Vioque, Jesus/A-1066-2008; Sanchez-Villegas,
   Almudena/T-6733-2019; Gomez Martinez, Carlos/AGJ-6387-2022;
   FERNANDEZ-ARANDA, FERNANDO/L-9762-2014; Schroder, Helmut/G-2586-2015;
   Salas-Salvado, Jordi/C-7229-2017; Becerra-Tomas, Nerea/H-3937-2018; Fito
   Colomer, Montse/C-1822-2012
OI Gomez Martinez, Carlos/0000-0002-3077-6702; Sorli, Jose
   V/0000-0002-0130-2006; FERNANDEZ-ARANDA, FERNANDO/0000-0002-2968-9898;
   Casas, Rosa/0000-0002-0211-9166; Schroder, Helmut/0000-0003-2231-5081;
   BABIO SANCHEZ, NANCY/0000-0003-3527-5277; Sanchez Villegas,
   Almudena/0000-0001-7733-9238; Lopez-Miranda, Jose/0000-0002-8844-0718;
   Lassale, Camille/0000-0002-9340-2708; Tojal Sierra,
   Lucas/0000-0001-5338-9601; MARTIN PELAEZ, SANDRA/0000-0002-2193-3913;
   Vioque, Jesus/0000-0002-2284-148X; Salas-Salvado,
   Jordi/0000-0003-2700-7459; Becerra-Tomas, Nerea/0000-0002-4429-6507;
   Cano-Ibanez, Naomi/0000-0002-3640-5486; Fito Colomer,
   Montse/0000-0002-1817-483X
FU European Research Council [340918]; official funding agency for
   biomedical research of the Spanish Government, ISCIII through the Fondo
   de Investigacion para la Salud (FIS) - European Regional Development
   Fund [PI13/00673, PI13/00492, PI13/00272, PI13/01123, PI13/00462,
   PI13/00233, PI13/02184, PI13/00728, PI13/01090, PI13/01056, PI14/01722,
   PI14/00636, PI14/00618, PI14/00696, PI14/01206, PI14/01919, PI14/00853,
   PI14/01374]; Recercaixa [2013ACUP00194]; Consejeria de Salud de la Junta
   de Andalucia [PI0458/2013, PS0358/2016, PI0137/2018]; Generalitat
   Valenciana [PROMETEO/2017/017]; CIBEROBN; FEDER funds [CB06/03]; ISCIII;
   International Nut&Dried Fruit Council-FESNAD Ndegreesnd longitudinal
   analyses in Spanish adult population with metabolic syndrome. Findings
   from PREDIMED-Plus trial [201302]; SEMERGEN;  [PI16/00473]; 
   [PI16/00662];  [PI16/01873];  [PI16/01094];  [PI16/00501]; 
   [PI16/00533];  [PI16/00381];  [PI16/00366];  [PI16/01522]; 
   [PI16/01120];  [PI17/00764];  [PI17/01183];  [PI17/00855]; 
   [PI17/01347];  [PI17/00525];  [PI17/01827];  [PI17/00532]; 
   [PI17/00215];  [PI17/01441];  [PI17/00508];  [PI17/01732];  [PI17/00926]
FX T The PREDIMED-Plus trial was supported by the European Research Council
   (Advanced Research Grant 2013-2018; 340918) grant to Miguel Angel
   Martinez-Gonzalez, and by the official funding agency for biomedical
   research of the Spanish Government, ISCIII through the Fondo de
   Investigacion para la Salud (FIS), which is cofunded by the European
   Regional Development Fund (four coordinated FIS projects led by Jordi
   Salas-Salvado and Josep Vidal), including the following projects:
   PI13/00673, PI13/00492, PI13/00272, PI13/01123, PI13/00462, PI13/00233,
   PI13/02184, PI13/00728, PI13/01090, PI13/01056, PI14/01722, PI14/00636,
   PI14/00618, PI14/00696, PI14/01206, PI14/01919, PI14/00853, PI14/01374,
   PI16/00473, PI16/00662, PI16/01873, PI16/01094, PI16/00501, PI16/00533,
   PI16/00381, PI16/00366, PI16/01522, PI16/01120, PI17/00764, PI17/01183,
   PI17/00855, PI17/01347, PI17/00525, PI17/01827, PI17/00532, PI17/00215,
   PI17/01441, PI17/00508, PI17/01732, PI17/00926, The Especial Action
   Project entitled: 'Implementacion y Evaluacion de una intervencion
   intensiva sobre la actividad fisica Cohorte PREDIMED-Plus' grant to
   Jordi Salas-Salvado, the Recercaixa grant to Jordi Salas-Salvado
   (2013ACUP00194), grants from the Consejeria de Salud de la Junta de
   Andalucia (PI0458/2013; PS0358/2016; PI0137/2018), the PROMETEO/2017/017
   grant from the Generalitat Valenciana, the SEMERGEN grant, and CIBEROBN
   and FEDER funds (CB06/03), ISCIII. International Nut&Dried Fruit
   Council-FESNAD N degrees 201302: Miguel Angel Martinez-Gonzalez (PI).
   None of the funding sources took part in the design, collection,
   analysis or interpretation of the data, or in the decision to submit the
   manuscript for publication. The corresponding author had full access to
   all the data in the study and had final responsibility to submit for
   publication.
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NR 49
TC 7
Z9 7
U1 2
U2 29
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 1368-9800
EI 1475-2727
J9 PUBLIC HEALTH NUTR
JI Public Health Nutr.
PD MAR
PY 2023
VL 26
IS 3
BP 598
EP 610
AR PII S1368980022001525
DI 10.1017/S1368980022001525
EA JUL 2022
PG 13
WC Public, Environmental & Occupational Health; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health; Nutrition & Dietetics
GA EN5E1
UT WOS:000836477900001
PM 35850714
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Raatikainen, I
   Vanhala, M
   Mäntyselkä, P
   Heinonen, A
   Koponen, H
   Kautiainen, H
   Korniloff, K
AF Raatikainen, Ilkka
   Vanhala, Mauno
   Mantyselka, Pekka
   Heinonen, Ari
   Koponen, Hannu
   Kautiainen, Hannu
   Korniloff, Katariina
TI Does level of leisure time physical activity, in a sample of patients
   with depression, predict health care utilization over a subsequent
   5-year period? Findings from a Finnish cohort study
SO MENTAL HEALTH AND PHYSICAL ACTIVITY
LA English
DT Article
DE Depression; Leisure time physical activity; Health care utilization;
   Health services
ID METABOLIC SYNDROME; RISK-FACTORS; SYMPTOMS; ASSOCIATION; DISORDERS;
   SERVICES; EXERCISE; DISEASE; WOMEN; PREVALENCE
AB Objectives: The main aim of this study was to investigate the association between leisure time physical activity (LTPA) and health care utilization (HCU) and furthermore, socio-demographic and clinical factors according to LTPA level among depressed patients based on data drawn from the Finnish Depression and Metabolic Syndrome in Adults (FDMSA)-study (2009-2016).
   Methods: 447 depressed patients aged 35-65 from municipalities within the Central Finland Hospital District participated in this study. Depressive symptoms (DS) were determined with the Beck Depression Inventory (a 10 points) and the psychiatric diagnosis confirmed with a diagnostic interview (M.I.N.I.). Severity of depression was evaluated using the Montgomery-Asberg Depression Rating Scale (MADRS). LTPA was assessed using a self reported questionnaire. Use of health services was counted from participant's health care records.
   Results: Of the 447 depressed patients, 25% reported their LTPA level as low, 41% as moderate and 34% as high. Among depressed patients, higher levels of LTPA were linearly associated with lower BDI (p < 0.001), MADRS (p = 0.002), BMI (p = 0.005), triglyceride (p = 0.025) and higher HDL (p = 0.002) values. LTPA level was not related to health care utilization among depressed patients. The health services most used were physician services.
   Conclusions: According to this study, the level of LTPA in baseline does not predict the future use of health care services among depressed patients in Finnish adult population. Although higher levels of LTPA are positively associated with many health-related factors, promoting PA alone is not enough when aiming to manage and modify HCU among depressed patients.
C1 [Raatikainen, Ilkka; Heinonen, Ari; Korniloff, Katariina] Univ Jyvaskyla, Fac Sport & Hlth Sci, Jyvaskyla, Finland.
   [Vanhala, Mauno] Cent Hosp Cent Finland, Primary Hlth Care Unit, Jyvaskyla, Finland.
   [Vanhala, Mauno; Mantyselka, Pekka] Univ Eastern Finland, Unit Primary Hlth Care, Kuopio, Finland.
   [Vanhala, Mauno; Mantyselka, Pekka] Kuopio Univ Hosp, Kuopio, Finland.
   [Koponen, Hannu] Univ Helsinki, Helsinki, Finland.
   [Koponen, Hannu] Helsinki Univ Hosp, Psychiat, Helsinki, Finland.
   [Kautiainen, Hannu] Kuopio Univ Hosp, Unit Primary Hlth Care, Kuopio, Finland.
   [Kautiainen, Hannu] Univ Helsinki, Unit Primary Hlth Care, Cent Hosp, Helsinki, Finland.
   [Kautiainen, Hannu] Univ Helsinki, Dept Gen Practice, Helsinki, Finland.
C3 University of Jyvaskyla; Central Finland Central Hospital; University of
   Eastern Finland; Kuopio University Hospital; University of Eastern
   Finland; University of Eastern Finland Hospital; University of Helsinki;
   University of Helsinki; Helsinki University Central Hospital; University
   of Eastern Finland; University of Eastern Finland Hospital; Kuopio
   University Hospital; University of Helsinki; Helsinki University Central
   Hospital; University of Helsinki
RP Raatikainen, I (corresponding author), Ruokotie 6 c, Jyvaskyla 40250, Finland.
EM ilkka.t.raatikainen@student.jyu.fi
RI ; Heinonen, Ari/A-9199-2014
OI Koponen, Hannu/0000-0002-7368-1869; Heinonen, Ari/0000-0002-3681-9953;
   Raatikainen, Ilkka/0000-0002-4040-9666
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NR 45
TC 6
Z9 7
U1 0
U2 9
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1755-2966
J9 MENT HEALTH PHYS ACT
JI Ment. Health Phys. Act.
PD OCT
PY 2018
VL 15
BP 40
EP 44
DI 10.1016/j.mhpa.2018.06.007
PG 5
WC Psychology, Clinical; Psychiatry
WE Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA HE0CA
UT WOS:000452933200009
DA 2025-06-11
ER

PT J
AU Jang, KW
   Hur, J
   Lee, DW
   Kim, SR
AF Jang, Kyu Won
   Hur, Jin
   Lee, Dong Won
   Kim, Seo Rin
TI Metabolic Syndrome, Kidney-Related Adiposity, and Kidney
   Microcirculation: Unraveling the Damage
SO BIOMEDICINES
LA English
DT Review
DE metabolic syndrome; kidney microcirculation; visceral adiposity;
   kidney-related fat
ID ANGIOTENSIN-ALDOSTERONE SYSTEM; GLOMERULAR-FILTRATION-RATE; RENAL
   GLUCOSE-METABOLISM; NITRIC-OXIDE PRODUCTION; CARDIOVASCULAR-DISEASE;
   ENDOTHELIAL DYSFUNCTION; INDEPENDENT PREDICTOR; LIPID-ACCUMULATION;
   INSULIN-RESISTANCE; FATTY KIDNEY
AB Metabolic syndrome (MetS) is a cluster of interrelated risk factors, including insulin resistance, hypertension, dyslipidemia, and visceral adiposity, all of which contribute to kidney microvascular injury and the progression of chronic kidney disease (CKD). However, the specific impact of each component of MetS on kidney microcirculation remains unclear. Given the increasing prevalence of obesity, understanding how visceral fat-particularly fat surrounding the kidneys-affects kidney microcirculation is critical. This review examines the consequences of visceral obesity and other components of MetS on renal microcirculation. These kidney-related fat deposits can contribute to the mechanical compression of renal vasculature, promote inflammation and oxidative stress, and induce endothelial dysfunction, all of which accelerate kidney damage. Each factor of MetS initiates a series of hemodynamic and metabolic disturbances that impair kidney microcirculation, leading to vascular remodeling and microvascular rarefaction. The review concludes by discussing therapeutic strategies targeting the individual components of MetS, which have shown promise in alleviating inflammation and oxidative stress. Integrated approaches that address both of the components of MetS and kidney-related adiposity may improve renal outcomes and slow the progression of CKD.
C1 [Jang, Kyu Won; Hur, Jin; Lee, Dong Won; Kim, Seo Rin] Pusan Natl Univ, Div Nephrol, Yangsan Hosp, Yangsan 50612, South Korea.
   [Jang, Kyu Won; Hur, Jin; Lee, Dong Won; Kim, Seo Rin] Pusan Natl Univ, Res Inst Convergence Biomed Sci & Technol, Yangsan Hosp, Yangsan 50612, South Korea.
   [Hur, Jin] Pusan Natl Univ, Sch Med, Dept Convergence Med, Yangsan 50612, South Korea.
   [Lee, Dong Won; Kim, Seo Rin] Pusan Natl Univ, Sch Med, Dept Internal Med, Yangsan 50612, South Korea.
C3 Pusan National University; Pusan National University Hospital; Pusan
   National University; Pusan National University Hospital; Pusan National
   University; Pusan National University
RP Kim, SR (corresponding author), Pusan Natl Univ, Div Nephrol, Yangsan Hosp, Yangsan 50612, South Korea.; Kim, SR (corresponding author), Pusan Natl Univ, Res Inst Convergence Biomed Sci & Technol, Yangsan Hosp, Yangsan 50612, South Korea.; Kim, SR (corresponding author), Pusan Natl Univ, Sch Med, Dept Internal Med, Yangsan 50612, South Korea.
EM rbdnjs0214@naver.com; gene44@pusan.ac.kr; dongwonlee@pusan.ac.kr;
   kim.seorin@pusan.ac.kr
OI Kim, Seo Rin/0000-0003-3552-0519; Hur, Jin/0000-0003-0692-0150
FU National Research Foundation of Korea (NRF) grant funded by the Korea
   government (MSIT) [2022R1A2C2093172]; National Research Foundation of
   Korea (NRF) - Korea government (MSIT) [20-2019-008]; Research Institute
   for Convergence of Biomedical Science and Technology, Pusan National
   University Yangsan Hospital
FX This research was supported by the National Research Foundation of Korea
   (NRF) grant funded by the Korea government (MSIT), grant number
   2022R1A2C2093172, and by the Research Institute for Convergence of
   Biomedical Science and Technology, Pusan National University Yangsan
   Hospital, grant number 20-2019-008.
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NR 151
TC 0
Z9 0
U1 4
U2 4
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2227-9059
J9 BIOMEDICINES
JI Biomedicines
PD DEC
PY 2024
VL 12
IS 12
AR 2706
DI 10.3390/biomedicines12122706
PG 17
WC Biochemistry & Molecular Biology; Medicine, Research & Experimental;
   Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Research & Experimental Medicine;
   Pharmacology & Pharmacy
GA Q7U1M
UT WOS:001386671400001
PM 39767613
OA gold
DA 2025-06-11
ER

PT J
AU Rogulj, D
   Konjevoda, P
   Milic, M
   Mladinic, M
   Domijan, AM
AF Rogulj, Dinko
   Konjevoda, Pasko
   Milic, Mirta
   Mladinic, Marin
   Domijan, Ana-Marija
TI Fatty liver index as an indicator of metabolic syndrome
SO CLINICAL BIOCHEMISTRY
LA English
DT Article
DE Fatty liver index; Metabolic syndrome; Oxidative stress; REPTree and
   SimpleCART algorithms; ROC curve analysis
ID C-REACTIVE PROTEIN; COMET ASSAY; DNA-DAMAGE; GAMMA-GLUTAMYLTRANSFERASE;
   OXIDATIVE DAMAGE; NATIONAL-HEALTH; OBESITY; ASSOCIATION; MARKERS; REPAIR
AB Objective: The aim of this study was to find an early indicator of metabolic syndrome (MetS).
   Design and methods: We measured several anthropometric, biochemical, haematological, and oxidative damage parameters in 128 middle-aged Caucasian men divided into two groups: patients with MetS (n=69) and healthy controls (n=59), and used Weka REPTree and SimpleCART algorithms to identify the most reliable predictor of MetS.
   Results: Oxidative damage parameters did not differ between the groups, suggesting that oxidative damage is less prominent at the early stage of MetS. The algorithms singled out fatty liver index (FLI) as the best variable for discriminating between healthy and MetS subjects. This finding was confirmed by the receiver-operating characteristic (ROC) curve analysis, which set FLI 68.53 as the threshold value for MetS diagnosis.
   Conclusions: FLI is the most reliable tool for diagnosing MetS. The absence of oxidative damage does not rule out oxidative stress but may indicate that MetS is at an early stage. (C) 2011 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
C1 [Domijan, Ana-Marija] Univ Zagreb, Fac Pharm & Biochem, Zagreb 10000, Croatia.
   [Rogulj, Dinko] Polyclin Sunce, Zagreb, Croatia.
   [Konjevoda, Pasko] Rudjer Boskovic Inst, NMR Ctr, Zagreb, Croatia.
   [Milic, Mirta; Mladinic, Marin] Inst Med Res & Occupat Hlth, Mutagenesis Unit, Zagreb 41000, Croatia.
C3 University of Zagreb; Rudjer Boskovic Institute; Institute for Medical
   Research & Occupational Health (IMROH)
RP Domijan, AM (corresponding author), Univ Zagreb, Fac Pharm & Biochem, A Kovacica 1, Zagreb 10000, Croatia.
EM adomijan@pharma.hr
RI ; Milic, Mirta/T-4887-2018
OI /0000-0002-5997-6986; Konjevoda, Pasko/0000-0003-3966-1132; Milic,
   Mirta/0000-0002-9837-7185
FU Department of Biochemistry and Molecular Biology at the Zagreb
   University Faculty of Pharmacy and Biochemistry
FX We wish to thank the Department of Biochemistry and Molecular Biology at
   the Zagreb University Faculty of Pharmacy and Biochemistry for financial
   support and the Mutagenesis Unit of the Institute for Medical Research
   and Occupational Health, Zagreb for the experimental part of the study.
   We also wish to thank Nevenka Kopjar and Davor Zeljezic for help in
   preparing the manuscript and Dado Cakalo for editing it to read better.
CR [Anonymous], 2008, MED JAD
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NR 34
TC 26
Z9 29
U1 0
U2 6
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0009-9120
EI 1873-2933
J9 CLIN BIOCHEM
JI Clin. Biochem.
PD JAN
PY 2012
VL 45
IS 1-2
BP 68
EP 71
DI 10.1016/j.clinbiochem.2011.10.014
PG 4
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA 879WY
UT WOS:000299364800014
PM 22056738
DA 2025-06-11
ER

PT J
AU La Russa, D
   Giordano, F
   Marrone, A
   Parafati, M
   Janda, E
   Pellegrino, D
AF La Russa, Daniele
   Giordano, Francesca
   Marrone, Alessandro
   Parafati, Maddalena
   Janda, Elzbieta
   Pellegrino, Daniela
TI Oxidative Imbalance and Kidney Damage in Cafeteria Diet-Induced Rat
   Model of Metabolic Syndrome: Effect of Bergamot Polyphenolic Fraction
SO ANTIOXIDANTS
LA English
DT Article
DE oxidative stress; biological antioxidant potential; kidney damage;
   cafeteria diet; bergamot polyphenolic fraction
ID BODY-MASS INDEX; FATTY LIVER-DISEASE; OBESITY; STRESS; RISK; MORTALITY;
   CANCER; HYPERTENSION; POPULATION; FLAVONOIDS
AB Obesity is a potent risk factor for kidney disease as it increases the possibility of developing diabetes and hypertension, and it has a direct impact on the development of chronic kidney disease and end-stage renal disease. In this study, we tested the effect of bergamot polyphenolic fraction in a cafeteria with diet-fed rats, an excellent experimental model for studying human metabolic syndrome, as it is able to induce severe obesity with insulin resistance and high plasma triglyceride levels more efficiently than a traditional lard-based high-fat diet used in rodent models. We analyzed the plasmatic oxidative balance by photometric tests, and the expression of cytoplasmic antioxidant enzymes (superoxide dismutase 1 and glutatione S-tranferasi P1) and apoptotic markers (Caspase 8 and 9) in kidney tissues by Western blot analysis. Our results clearly showed that the cafeteria diet induces a marked pro-oxidant effect: significant reduction of plasmatic antioxidant capacity; downregulation of cytoplasmic antioxidant enzymes expression; and activation of apoptotic pathways. All these hallmarks of redox disequilibrium were mitigated by treatment with polyphenolic fraction of bergamot, highlighting its antioxidant effect in the metabolic syndrome. Our data show that the link between obesity and renal damage could be represented by oxidative stress.
C1 [La Russa, Daniele; Giordano, Francesca] Univ Calabria, Dept Pharm Hlth & Nutr Sci, I-87036 Arcavacata Di Rende, Italy.
   [La Russa, Daniele; Marrone, Alessandro; Pellegrino, Daniela] Univ Calabria, LARSO Anal & Res Oxidat Stress Lab, I-87036 Arcavacata Di Rende, Italy.
   [Marrone, Alessandro; Pellegrino, Daniela] Univ Calabria, Dept Biol Ecol & Earth Sci, I-87036 Arcavacata Di Rende, Italy.
   [Parafati, Maddalena; Janda, Elzbieta] Magna Graecia Univ Catanzaro, Dept Hlth Sci, Campus Germaneto, I-88100 Catanzaro, Italy.
C3 University of Calabria; University of Calabria; University of Calabria;
   Magna Graecia University of Catanzaro
RP Pellegrino, D (corresponding author), Univ Calabria, LARSO Anal & Res Oxidat Stress Lab, I-87036 Arcavacata Di Rende, Italy.; Pellegrino, D (corresponding author), Univ Calabria, Dept Biol Ecol & Earth Sci, I-87036 Arcavacata Di Rende, Italy.
EM daniele.larussa@unical.it; francesca.giordano@unical.it;
   alexbrown993@gmail.com; mparafati@unicz.it; janda@unicz.it;
   danielapellegrino@unical.it
RI Giordano, Francesca/E-4039-2017; Marrone, Alessandro/AAM-9319-2021;
   Janda, Elzbieta/AFQ-7061-2022; Parafati, Maddalena/HPG-4694-2023; La
   Russa, Daniele/K-3654-2019
OI Janda, Elzbieta/0000-0002-6787-7291; Marrone,
   Alessandro/0000-0003-0489-0955; Pellegrino, Daniela/0000-0002-9815-5195;
   Parafati, Maddalena/0000-0002-7627-2729; La Russa,
   Daniele/0000-0003-1887-2854
FU University of Calabria; Herbal and Antioxidant Derivatives (H& AD)
   S.r.l., Bianco (RC), Italy; Nutramed Consortium [PON03PE 00078]; 
   [PON3a-00359]
FX This research was financed by: University of Calabria; PON3a-00359
   Research and Competitiveness grant and Nutramed Consortium (PON03PE
   00078); Herbal and Antioxidant Derivatives (H& AD) S.r.l., Bianco (RC),
   Italy.
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NR 81
TC 42
Z9 43
U1 0
U2 6
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD MAR 16
PY 2019
VL 8
IS 3
AR 66
DI 10.3390/antiox8030066
PG 15
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA HT1FZ
UT WOS:000464310800001
PM 30884780
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Kochi, T
   Shimizu, M
   Ohno, T
   Baba, A
   Sumi, T
   Kubota, M
   Shirakami, Y
   Tsurumi, H
   Tanaka, T
   Moriwaki, H
AF Kochi, Takahiro
   Shimizu, Masahito
   Ohno, Tomohiko
   Baba, Atsushi
   Sumi, Takafumi
   Kubota, Masaya
   Shirakami, Yohei
   Tsurumi, Hisashi
   Tanaka, Takuji
   Moriwaki, Hisataka
TI Enhanced Development of Azoxymethane-Induced Colonic Preneoplastic
   Lesions in Hypertensive Rats
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE hypertension; colon carcinogenesis; oxidative stress; inflammation;
   angiotensin-II
ID RENIN-ANGIOTENSIN SYSTEM; NECROSIS-FACTOR-ALPHA; METABOLIC SYNDROME;
   BLOOD-PRESSURE; CANCER; RISK; OBESITY; INHIBITORS; MODEL; EXPRESSION
AB Metabolic syndrome is associated with an increased risk of colorectal cancer. This study investigated the impact of hypertension, a component of metabolic syndrome, on azoxymethane (AOM)-induced colorectal carcinogenesis using SHRSP/Izm (SHRSP) non-diabetic/hypertensive rats and SHRSP.Z-Lepr(fa)/IzmDmcr (SHRSP-ZF) diabetic/hypertensive rats. Male 6-week-old SHRSP, SHRSP-ZF, and control non-diabetic/normotensive Wister Kyoto/Izm (WKY) rats were given 2 weekly intraperitoneal injections of AOM (20 mg/kg body weight). Two weeks after the last injection of AOM, the SHRSP and SHRSP-ZF rats became hypertensive compared to the control WKY rats. Serum levels of angiotensin-II, the active product of the renin-angiotensin system, were elevated in both SHRSP and SHRSP-ZF rats, but only the SHRSP-ZF rats developed insulin resistance, dyslipidemia, and hyperleptinemia and exhibited an increase in adipose tissue. The development of AOM-induced colonic preneoplastic lesions and aberrant crypts foci, was significantly accelerated in both SHRSP and SHRSP-ZF hypertensive rats, compared to WKY normotensive rats. Furthermore, induction of oxidative stress and exacerbation of inflammation were observed in the colonic mucosa and systemically in SHRSP and SHRSP-ZF rats. Our findings suggest that hypertension plays a role in the early stage of colorectal carcinogenesis by inducing oxidative stress and chronic inflammation, which might be associated with activation of the renin-angiotensin system.
C1 [Kochi, Takahiro; Shimizu, Masahito; Ohno, Tomohiko; Baba, Atsushi; Sumi, Takafumi; Kubota, Masaya; Shirakami, Yohei; Tsurumi, Hisashi; Moriwaki, Hisataka] Gifu Univ, Grad Sch Med, Dept Internal Med, Gifu 5011194, Japan.
   [Tanaka, Takuji] Gifu Univ, Grad Sch Med, Dept Tumor Pathol, Gifu 5011194, Japan.
C3 Gifu University; Gifu University
RP Shimizu, M (corresponding author), Gifu Univ, Grad Sch Med, Dept Internal Med, Gifu 5011194, Japan.
EM kottii924@yahoo.co.jp; shimim-gif@umin.ac.jp; tomohikooh@hotmail.com;
   babagif@yahoo.co.jp; sumieron@gmail.com; kubota-gif@umin.ac.jp;
   shirakamiyy@yahoo.co.jp; htsuru@gifu-u.ac.jp; takutt@toukaisaibou.co.jp;
   hmori@gifu-u.ac.jp
FU Grants-in-Aid for Scientific Research [23501324] Funding Source: KAKEN
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NR 42
TC 10
Z9 12
U1 0
U2 7
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD JUL
PY 2013
VL 14
IS 7
BP 14700
EP 14711
DI 10.3390/ijms140714700
PG 12
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 188DH
UT WOS:000322171700104
PM 23860206
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Acquaviva, R
   Di Giacomo, C
   Vanella, L
   Santangelo, R
   Sorrenti, V
   Barbagallo, I
   Genovese, C
   Mastrojeni, S
   Ragusa, S
   Iauk, L
AF Acquaviva, Rosaria
   Di Giacomo, Claudia
   Vanella, Luca
   Santangelo, Rosa
   Sorrenti, Valeria
   Barbagallo, Ignazio
   Genovese, Carlo
   Mastrojeni, Silvana
   Ragusa, Salvatore
   Iauk, Liliana
TI Antioxidant Activity of Extracts of Momordica Foetida Schumach.
   et Thonn.
SO MOLECULES
LA English
DT Article
DE Momordica foetida Schumach. et Thonn.; antioxidant activity; adipogenic
   differentiation
ID ADIPOCYTE DIFFERENTIATION; OXIDATIVE STRESS; STEM-CELLS; INCREASES; FAT;
   OBESITY; PLANTS
AB Momordica foetida Schumach. et Thonn. (Cucurbitaceae) is a perennial climbing herb with tendrils, found in swampy areas in Central Uganda. Antidiabetic and antilipogenic activities were reported for some Momordica species, however the mechanism of action is still unknown. Oxidative stress may represent an important pathogenic mechanism in obesity-associated metabolic syndrome. The present study evaluated free radical scavenging capacity of different concentrations of aqueous, methanolic and dichloromethane leaf extracts of Momordica foetida Schumach. et Thonn. and the ability of these extracts to inhibit in vitro plasma lipid peroxidation; in addition, healthy human adipose mesenchymal stem cell cultures were used in order to test the hypothesis that these extracts may affect adipocyte differentiation. Results obtained in this study suggested that aqueous extract might be useful in preventing metabolic syndrome.
C1 [Acquaviva, Rosaria; Di Giacomo, Claudia; Vanella, Luca; Santangelo, Rosa; Sorrenti, Valeria; Barbagallo, Ignazio] Univ Catania, Dept Drug Sci, Biochem Sect, I-95125 Catania, Italy.
   [Genovese, Carlo; Mastrojeni, Silvana; Iauk, Liliana] Univ Catania, Dept Biomed Sci, Microbiol Sect, I-95125 Catania, Italy.
   [Ragusa, Salvatore] Magna Graecia Univ Catanzaro, Dept Hlth Sci, I-88100 Catanzaro, Italy.
C3 University of Catania; University of Catania; Magna Graecia University
   of Catanzaro
RP Di Giacomo, C (corresponding author), Univ Catania, Dept Drug Sci, Biochem Sect, I-95125 Catania, Italy.
EM cdigiaco@unict.it
RI Acquaviva, Rosaria/A-6750-2018; Vanella, Luca/J-7354-2016; GENOVESE,
   Carlo/D-7837-2012
OI Vanella, Luca/0000-0002-6314-6029; Di Giacomo,
   Claudia/0000-0002-2665-0007; GENOVESE, Carlo/0000-0003-2463-9047;
   Barbagallo, Ignazio/0000-0002-7761-0662; Acquaviva,
   Rosaria/0000-0002-3139-1177; Sorrenti, Valeria/0000-0002-5973-1495
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NR 27
TC 20
Z9 20
U1 0
U2 17
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1420-3049
J9 MOLECULES
JI Molecules
PD MAR
PY 2013
VL 18
IS 3
BP 3241
EP 3249
DI 10.3390/molecules18033241
PG 9
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 112RV
UT WOS:000316611700058
PM 23486103
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Xu, J
   Wei, HL
   Sun, ZY
   Li, WK
   Long, JA
   Liu, JK
   Feng, ZH
   Cao, K
AF Xu, Jie
   Wei, Huanglong
   Sun, Zhenyu
   Li, Wankang
   Long, Jiangang
   Liu, Jiankang
   Feng, Zhihui
   Cao, Ke
TI Hydroxytyrosol as a Mitochondrial Homeostasis Regulator: Implications in
   Metabolic Syndrome and Related Diseases
SO ANTIOXIDANTS
LA English
DT Review
DE hydroxytyrosol; mitochondria; metabolic syndrome; mitochondrial delivery
   system; synergistic therapies
ID ENDOPLASMIC-RETICULUM STRESS; PIGMENT EPITHELIAL-CELLS; OXIDATIVE
   STRESS; COGNITIVE FUNCTION; INDUCED MUSCLE; BIOGENESIS; DYSFUNCTION;
   OLIVE; AUTOPHAGY; ACTIVATION
AB Hydroxytyrosol (HT), a principal bioactive phytochemical abundant in Mediterranean dietary sources, has emerged as a molecule of significant scientific interest owing to its multifaceted health-promoting properties. Accumulating evidence suggests that HT's therapeutic potential in metabolic disorders extends beyond conventional antioxidant capacity to encompass mitochondrial regulatory networks. This review synthesizes contemporary evidence from our systematic investigations and the existing literature to delineate HT's comprehensive modulatory effects on mitochondrial homeostasis. We systematically summarized the impact of HT on mitochondrial dynamics (fusion/fission equilibrium), biogenesis and energy metabolism, mitophagy, inter-organellar communication with the endoplasmic reticulum, and microbiota-mitochondria crosstalk. Through this multidimensional analysis, we established HT as a mitochondrial homeostasis modulator with potential therapeutic applications in metabolic syndrome (MetS) and its related pathologies including type 2 diabetes mellitus, obesity-related metabolic dysfunction, dyslipidemia, non-alcoholic steatohepatitis, and hypertension-related complications. Moreover, we further discussed translational challenges in HT research, emphasizing the imperative for direct target identification, mitochondrial-targeted delivery system development, and combinatorial therapeutic strategies. Collectively, this review provides a mechanistic framework for advancing HT research and accelerating its clinical implementation in MetS and its related diseases.
C1 [Xu, Jie; Wei, Huanglong; Sun, Zhenyu; Li, Wankang; Long, Jiangang; Liu, Jiankang; Cao, Ke] Xi An Jiao Tong Univ, Sch Life Sci & Technol, Key Lab Biomed Informat Engn, Minist Educ,Ctr Mitochondrial Biol & Med, Xian 710049, Peoples R China.
   [Liu, Jiankang; Feng, Zhihui] Univ Hlth & Rehabil Sci, Sch Hlth & Life Sci, Qingdao 266071, Peoples R China.
   [Feng, Zhihui] Xi An Jiao Tong Univ, Frontier Inst Sci & Technol, Xian 710049, Peoples R China.
C3 Ministry of Education - China; Xi'an Jiaotong University; University of
   Health & Rehabilitation Sciences; Xi'an Jiaotong University
RP Cao, K (corresponding author), Xi An Jiao Tong Univ, Sch Life Sci & Technol, Key Lab Biomed Informat Engn, Minist Educ,Ctr Mitochondrial Biol & Med, Xian 710049, Peoples R China.; Feng, ZH (corresponding author), Univ Hlth & Rehabil Sci, Sch Hlth & Life Sci, Qingdao 266071, Peoples R China.; Feng, ZH (corresponding author), Xi An Jiao Tong Univ, Frontier Inst Sci & Technol, Xian 710049, Peoples R China.
EM xj0322@xjtu.edu.cn; weihuanglong@stu.xjtu.edu.cn;
   zhenyu_sun@stu.xjtu.edu.cn; lwk0626@stu.xjtu.edu.cn;
   jglong@mail.xjtu.edu.cn; jkliu@uor.edu.cn; zhfeng@xjtu.edu.cn;
   caoke2016@mail.xjtu.edu.cn
RI Sun, Zhenyu/ITV-7024-2023
FU National Natural Science Foundations of China; Youth Talent Support
   Program of Shaanxi Association for Science and Technology [20230214];
   Natural Science Foundation of Sichuan Province [2025ZNSFSC1704];
   Fundamental Research Funds for the Central Universities; Taishan
   Scholars Project of Shandong Province; Shandong Provincial Natural
   Foundation [ZR2023JQ011];  [82271727];  [82300902];  [32071154]; 
   [32271184];  [32350025]
FX This work was funded by the National Natural Science Foundations of
   China (No. 82271727 to K.C., No. 82300902 to J.X., No. 32071154,
   32271184, 32350025 to Z.F), the Youth Talent Support Program of Shaanxi
   Association for Science and Technology (No. 20230214 to K.C.), the
   Natural Science Foundation of Sichuan Province (No. 2025ZNSFSC1704 to
   K.C.), the Fundamental Research Funds for the Central Universities (No.
   xzy012023012 to J.X.), the Taishan Scholars Project of Shandong Province
   (Z.F.), and the Shandong Provincial Natural Foundation (ZR2023JQ011,
   Z.F.).
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NR 132
TC 0
Z9 0
U1 4
U2 4
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD MAR 27
PY 2025
VL 14
IS 4
AR 398
DI 10.3390/antiox14040398
PG 18
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA 1VS6R
UT WOS:001474792700001
PM 40298640
DA 2025-06-11
ER

PT J
AU Mignini, I
   Galasso, L
   Piccirilli, G
   Calvez, V
   Termite, F
   Esposto, G
   Borriello, R
   Miele, L
   Ainora, ME
   Gasbarrini, A
   Zocco, MA
AF Mignini, Irene
   Galasso, Linda
   Piccirilli, Giulia
   Calvez, Valentin
   Termite, Fabrizio
   Esposto, Giorgio
   Borriello, Raffaele
   Miele, Luca
   Ainora, Maria Elena
   Gasbarrini, Antonio
   Zocco, Maria Assunta
TI Interplay of Oxidative Stress, Gut Microbiota, and Nicotine in
   Metabolic-Associated Steatotic Liver Disease (MASLD)
SO ANTIOXIDANTS
LA English
DT Review
DE metabolic-associated steatotic liver; nicotine; cigarette smoking;
   oxidative stress; gut microbiota; gut-liver axis
ID NONALCOHOLIC FATTY LIVER; GAMMA-COACTIVATOR 1-ALPHA; DIET-INDUCED
   OBESITY; MITOCHONDRIAL-FUNCTION; INSULIN-RESISTANCE;
   FAECALIBACTERIUM-PRAUSNITZII; BODY-WEIGHT; SMOKING; DYSFUNCTION;
   FIBROSIS
AB Oxidative stress has been described as one of the main drivers of intracellular damage and metabolic disorders leading to metabolic syndrome, a major health problem worldwide. In particular, free radicals alter lipid metabolism and promote lipid accumulation in the liver, existing in the hepatic facet of metabolic syndrome, the metabolic dysfunction-associated steatotic liver disease (MASLD). Recent literature has highlighted how nicotine, especially if associated with a high-fat diet, exerts a negative effect on the induction and progression of MASLD by upregulating inflammation and increasing oxidative stress, abdominal fat lipolysis, and hepatic lipogenesis. Moreover, considerable evidence shows the central role of intestinal dysbiosis in the pathogenesis of MASLD and the impact of nicotine-induced oxidative stress on the gut microbiome. This results in an intricate network in which oxidative stress stands at the intersection point between gut microbiome, nicotine, and MASLD. The aim of this review is to delve into the molecular mechanisms linking tobacco smoking and MASLD, focusing on nicotine-induced microbiota modifications and their impact on MASLD development.
C1 [Mignini, Irene; Galasso, Linda; Piccirilli, Giulia; Calvez, Valentin; Termite, Fabrizio; Esposto, Giorgio; Borriello, Raffaele; Miele, Luca; Ainora, Maria Elena; Gasbarrini, Antonio; Zocco, Maria Assunta] Univ Cattolica Sacro Cuore, Fdn Policlin Univ A Gemelli IRCCS, CEMAD Digest Dis Ctr, Largo A Gemelli 8, I-00168 Rome, Italy.
C3 Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli
RP Zocco, MA (corresponding author), Univ Cattolica Sacro Cuore, Fdn Policlin Univ A Gemelli IRCCS, CEMAD Digest Dis Ctr, Largo A Gemelli 8, I-00168 Rome, Italy.
EM irene.mignini@guest.policlinicogemelli.it;
   linda.galasso@guest.policlinicogemelli.it; giulia.piccirilli01@icatt.it;
   valentin.calvez@guest.policlinicogemelli.it;
   fabrizio.termite01@icatt.it;
   giorgio.esposto@guest.policlinicogemelli.it;
   raffaele.borriello@unicatt.it; luca.miele@policlinicogemelli.it;
   mariaelena.ainora@policlinicogemelli.it; antonio.gasbarrini@unicatt.it;
   mariaassunta.zocco@unicatt.it
RI Calvez, Valentin/IQS-3383-2023; Gasbarrini, Antonio/AAB-8487-2019;
   Borriello, Raffaele/LTY-8031-2024; Miele, Luca/C-2255-2015; Mignini,
   Irene/IQU-0380-2023
OI Gasbarrini, Antonio/0000-0002-6230-1779; Borriello,
   Raffaele/0000-0002-4861-8040; Miele, Luca/0000-0003-3464-0068; Mignini,
   Irene/0000-0002-8192-631X; ainora, maria elena/0000-0001-5847-1065;
   Termite, Fabrizio/0009-0005-0406-2705; Zocco, Maria
   Assunta/0000-0002-0814-9542
FU Fondazione Roma
FX :Thanks to Fondazione Roma for the continuous support of our scientific
   research.
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NR 155
TC 1
Z9 1
U1 7
U2 7
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD DEC
PY 2024
VL 13
IS 12
AR 1532
DI 10.3390/antiox13121532
PG 18
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA Q4C1D
UT WOS:001384172300001
PM 39765860
OA gold
DA 2025-06-11
ER

PT J
AU Zhang, XL
   Li, Q
   Zhao, J
   Li, XT
   Sun, XF
   Yang, HY
   Wu, ZY
   Yang, JM
AF Zhang, Xinling
   Li, Qiang
   Zhao, Jing
   Li, Xiangting
   Sun, Xiaofei
   Yang, Hongyan
   Wu, Zongyin
   Yang, Jianmin
TI Effects of combination of statin and calcium channel blocker in patients
   with cardiac syndrome X
SO CORONARY ARTERY DISEASE
LA English
DT Article
DE calcium channel blocker; cardiac syndrome X; combination therapy; statin
ID MICROVASCULAR DYSFUNCTION; THERAPY; ANGINA; FLOW
AB ObjectivesStatins and calcium channel blockers have been proven beneficial toward improvement of endothelial function. The aim of this study was to compare the effect of combination therapy of statin and calcium channel blocker with solo treatment in patients with cardiac syndrome X.Methods and resultsSixty-eight patients with cardiac syndrome X were divided randomly into three groups: fluvastatin (40 mg/day, n=23), diltiazem (90 mg/day, n=22), and combination of fluvastatin (40 mg/day) and diltiazem (90 mg/day, n=23). At the end of 90 days, the coronary flow reserve was improved in the three groups (fluvastatin-treated group: 23.2%; diltiazem-treated group: 12.4%; fluvastatin+diltiazem-treated group: 29.1%, all P<0.05). The time to 1 mm ST segment depression increased significantly in the fluvastatin-treated group (from 24197 to 410 +/- 140 s, P<0.05), the diltiazem-treated group (from 258 +/- 91 to 392 +/- 124 s, P<0.05), and the fluvastatin+diltiazem-treated group (from 250 +/- 104 to 446 +/- 164 s, P<0.05). The improvement in coronary flow reserve and prolonged time to 1 mm ST segment depression in the combination treatment group were more remarkable than in those who received monotherapy. Combination therapy also induced a significant increase (35.6%, P<0.05) in nitric oxide and an apparent reduction (48.7%, P<0.05) in endothelin-1.ConclusionCombination treatment with fluvastatin and diltiazem is more effective on endothelial function and exercise tolerance than solo treatment in patients with cardiac syndrome X. The benefits of these drugs may be related to the elevation of nitric oxide and reduction of endothelin-1. (C) 2013 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
C1 [Zhang, Xinling; Li, Qiang; Li, Xiangting; Sun, Xiaofei; Wu, Zongyin] Jining First Peoples Hosp, Ctr Heart, Jining 272011, Shandong, Peoples R China.
   [Zhao, Jing] Shandong Univ, Jinan Cent Hosp, Dept Neurol, Jinan 250100, Peoples R China.
   [Yang, Hongyan] Shandong Univ, Jinan Cent Hosp, Dept Oncol, Jinan 250100, Peoples R China.
   [Yang, Jianmin] Shandong Univ, Qilu Hosp, Chinese Minist Educ, Key Lab Cardiovasc Remodeling & Funct Res, Jinan 250100, Peoples R China.
   [Yang, Jianmin] Shandong Univ, Qilu Hosp, Chinese Minist Hlth, Jinan 250100, Peoples R China.
C3 Shandong University; Shandong First Medical University & Shandong
   Academy of Medical Sciences; Shandong First Medical University &
   Shandong Academy of Medical Sciences; Shandong University; Ministry of
   Education - China; Shandong University; Shandong University
RP Wu, ZY (corresponding author), Jining First Peoples Hosp, 6 Jiankang Rd, Jining 272011, Shandong, Peoples R China.
EM wuzysp@163.com
RI Yang, Jianmin/AAB-4237-2020; Yang, Hongyan/IZQ-2790-2023
FU National Natural Science Foundation of China [81100207]
FX This work was supported by a grant from the National Natural Science
   Foundation of China (No. 81100207).
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NR 13
TC 46
Z9 51
U1 0
U2 7
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0954-6928
EI 1473-5830
J9 CORONARY ARTERY DIS
JI Coronary Artery Dis.
PD JAN
PY 2014
VL 25
IS 1
BP 40
EP 44
DI 10.1097/MCA.0000000000000054
PG 5
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 274TW
UT WOS:000328630100008
PM 24256699
OA Bronze
DA 2025-06-11
ER

PT J
AU Byrne, ME
   LeMay-Russell, S
   Tanofsky-Kraff, M
AF Byrne, Meghan E.
   LeMay-Russell, Sarah
   Tanofsky-Kraff, Marian
TI Loss-of-Control Eating and Obesity Among Children and Adolescents
SO CURRENT OBESITY REPORTS
LA English
DT Article
DE Loss-of-control eating; Obesity; Overweight; Binge eating; Pediatric;
   Eating disorders
ID EXCESS WEIGHT-GAIN; INTERPERSONAL PSYCHOTHERAPY; ATTENTIONAL BIAS; MEAL
   INTAKE; HIGH-RISK; DISORDERS; GIRLS; BEHAVIORS; ASSOCIATIONS; OVERWEIGHT
AB Purpose of ReviewThis review summarizes findings on pediatric loss-of-control (LOC) eating and obesity published since 2013 in relation to physiological, socioenvironmental, and psychological factors.Recent FindingsLOC eating and obesity are highly comorbid in youth. Genetic and physiological risk factors are associated with the development of LOC eating. Adverse physiological outcomes of LOC eating include increased risk for overweight and obesity and greater dysfunction in components of metabolic syndrome. Socioenvironmental, psychological, and behavioral factors, such as weight-based teasing, dieting, negative affect, emotion dysregulation, and aspects of cognitive functioning, are consistently related to LOC eating in youth, independent of weight. Prospectively, LOC eating may predict the onset of anxiety disorders, depression, and more severe eating psychopathology later in life. Updates on interventions and future directions are discussed.SummaryLOC eating may be a key symptom to target adverse physiological and psychological outcomes; however, treatments are limited and require further examination.
C1 [Byrne, Meghan E.; LeMay-Russell, Sarah; Tanofsky-Kraff, Marian] USUHS, Dept Med & Clin Psychol, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA.
RP Tanofsky-Kraff, M (corresponding author), USUHS, Dept Med & Clin Psychol, 4301 Jones Bridge Rd, Bethesda, MD 20814 USA.
EM marian.tanofsky-kraff@usuhs.edu
OI Byrne, Meghan/0000-0002-4745-649X
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NR 73
TC 57
Z9 61
U1 2
U2 27
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 2162-4968
J9 CURR OBES REP
JI Curr. Obes. Rep.
PD MAR
PY 2019
VL 8
IS 1
BP 33
EP 42
DI 10.1007/s13679-019-0327-1
PG 10
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA HQ2EZ
UT WOS:000462214200005
PM 30701372
DA 2025-06-11
ER

PT J
AU Song, J
AF Song, Juhyun
TI Amygdala activity and amygdala-hippocampus connectivity: Metabolic
   diseases, dementia, and neuropsychiatric issues
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Review
DE Amygdala; Amygdala-hippocampal connectivity; Metabolic syndromes;
   Dementia; Emotional memory
ID MILD COGNITIVE IMPAIRMENT; TYPE-2 DIABETES-MELLITUS; FISH-OIL
   SUPPLEMENTATION; MEDIAL TEMPORAL ATROPHY; ANXIETY-LIKE BEHAVIOR;
   ALZHEIMERS-DISEASE; BASOLATERAL AMYGDALA; INSULIN-RESISTANCE;
   FATTY-ACID; EMOTIONAL MEMORY
AB With rapid aging of the population worldwide, the number of people with dementia is dramatically increasing. Some studies have emphasized that metabolic syndrome, which includes obesity and diabetes, leads to increased risks of dementia and cognitive decline. Factors such as insulin resistance, hyperglycemia, high blood pressure, dyslipidemia, and central obesity in metabolic syndrome are associated with synaptic failure, neuro-inflammation, and imbalanced neurotransmitter levels, leading to the progression of dementia. Due to the positive correlation between diabetes and dementia, some studies have called it "type 3 diabetes". Recently, the number of patients with cognitive decline due to metabolic imbalances has considerably increased. In addition, recent studies have reported that neuropsychiatric issues such as anxiety, depressive behavior, and impaired attention are common factors in patients with metabolic disease and those with dementia. In the central nervous system (CNS), the amygdala is a central region that regulates emotional memory, mood disorders, anxiety, attention, and cognitive function. The connectivity of the amygdala with other brain regions, such as the hip-pocampus, and the activity of the amygdala contribute to diverse neuropathological and neuropsychiatric issues. Thus, this review summarizes the significant consequences of the critical roles of amygdala connectivity in both metabolic syndromes and dementia. Further studies on amygdala function in metabolic imbalance-related de-mentia are needed to treat neuropsychiatric problems in patients with this type of dementia.
C1 [Song, Juhyun] Chonnam Natl Univ, Dept Anat, Med Sch, Hwasun 58128, Jeollanam Do, South Korea.
C3 Chonnam National University
RP Song, J (corresponding author), Chonnam Natl Univ, Dept Anat, Med Sch, Hwasun 58128, Jeollanam Do, South Korea.
EM juhyunsong@chonnam.ac.kr
FU National Research Foundation of Korea (NRF), Republic of Korea [HCRI
   22019]; Chonnam National University Hwasun Hospital Institute for
   Biomedical Science, Republic of Korea;  [2022R1A2C1006125]
FX This study was supported by the National Research Foundation of Korea
   (NRF grant 2022R1A2C1006125 to Juhyun Song) , Republic of Korea, and the
   Chonnam National University Hwasun Hospital Institute for Biomedical
   Science, Republic of Korea (grant no. HCRI 22019 to Juhyun Song) . We
   thank BioRender for creating the figures.
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NR 328
TC 28
Z9 30
U1 3
U2 33
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD JUN
PY 2023
VL 162
AR 114647
DI 10.1016/j.biopha.2023.114647
EA APR 2023
PG 14
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA P9BP9
UT WOS:001053558200001
PM 37011482
OA gold
DA 2025-06-11
ER

PT J
AU Inafuku, M
   Matsuzaki, G
   Oku, H
AF Inafuku, Masashi
   Matsuzaki, Goro
   Oku, Hirosuke
TI Intravenous Mycobacterium Bovis Bacillus Calmette-Guerin
   Ameliorates Nonalcoholic Fatty Liver Disease in Obese, Diabetic
   ob/ob Mice
SO PLOS ONE
LA English
DT Article
ID ENDOPLASMIC-RETICULUM STRESS; TUMOR-NECROSIS-FACTOR; INSULIN-RESISTANCE;
   METABOLIC SYNDROME; IMMUNE-RESPONSE; NOD MICE; HELICOBACTER-PYLORI;
   ADIPOSE-TISSUE; TUBERCULOSIS; PATHOGENESIS
AB Inflammation and immune response profoundly influence metabolic syndrome and fatty acid metabolism. To analyze influence of systemic inflammatory response to metabolic syndrome, we inoculated an attenuated vaccine strain of Mycobacterium bovis Bacillus Calmette-Guerin (BCG) into leptin-deficient ob/ob mice. BCG administration significantly decreased epididymal white adipose tissue weight, serum insulin levels, and a homeostasis model assessment of insulin resistance. Serum high molecular weight (HMW) adiponectin level and HMW/total adiponectin ratio of the BCG treated mice were significantly higher than those of control mice. Hepatic triglyceride accumulation and macrovesicular steatosis were markedly alleviated, and the enzymatic activities and mRNA levels of lipogenic-related genes in liver were significantly decreased in the BCG injected mice. We also exposed human hepatocellular carcinoma HepG2 cells to high levels of palmitate, which enhanced endoplasmic reticulum stress-related gene expression and impaired insulin-stimulated Akt phosphorylation (Ser473). BCG treatment ameliorated both of these detrimental events. The present study therefore suggested that BCG administration suppressed development of nonalcoholic fatty liver disease, at least partly, by alleviating fatty acid-induced insulin resistance in the liver.
C1 [Inafuku, Masashi; Oku, Hirosuke] Univ Ryukyus, Trop Biosphere Res Ctr, Dept Trop Bioresources, Nishihara, Okinawa 90301, Japan.
   [Matsuzaki, Goro] Univ Ryukyus, Trop Biosphere Res Ctr, Dept Infect Dis, Nishihara, Okinawa 90301, Japan.
C3 University of the Ryukyus; University of the Ryukyus
RP Inafuku, M (corresponding author), Univ Ryukyus, Trop Biosphere Res Ctr, Dept Trop Bioresources, Nishihara, Okinawa 90301, Japan.
EM h098648@eve.u-ryukyu.ac.jp
RI Matsuzaki, Goro/AAX-3110-2020
FU JSPS KAKENHI [2400755]; Grants-in-Aid for Scientific Research [25293105]
   Funding Source: KAKEN
FX This work was supported by the JSPS KAKENHI, Grant Number
   2400755(Identify author, MI), (http://www.jsps.go.jp/english/e-grants).
   The funder had no role in study design, data collection and analysis,
   decision to publish, or preparation of the manuscript.
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NR 58
TC 11
Z9 11
U1 0
U2 7
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JUN 3
PY 2015
VL 10
IS 6
AR e0128676
DI 10.1371/journal.pone.0128676
PG 16
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA CJ7ST
UT WOS:000355700700114
PM 26039731
OA Green Submitted, gold, Green Published
DA 2025-06-11
ER

PT J
AU Mohamed, SM
   Shalaby, MA
   El-Shiekh, RA
   Bakr, AF
   Rashad, MM
   Emam, SR
   El-Banna, HA
AF Mohamed, Salma Mostafa
   Shalaby, Mostafa Abbas
   El-Shiekh, Riham A.
   Bakr, Alaa F.
   Rashad, Maha M.
   Emam, Shimaa R.
   El-Banna, Hossny A.
TI Vitis vinifera L. seed standardized extract; a promising
   therapeutic against metabolic syndrome induced by
   high-fat/high-carbohydrate diet and streptozotocin in rats
SO SOUTH AFRICAN JOURNAL OF BOTANY
LA English
DT Article
DE Grape seeds; Metabolic syndrome; Enzyme inhibition assays;
   Standardization; Catechin; HPLC
ID INDUCED OXIDATIVE STRESS; GRAPE SEED; CARDIOVASCULAR RISK;
   INSULIN-RESISTANCE; NRF2; PROANTHOCYANIDINS; INFLAMMATION;
   HEPATOTOXICITY; ACTIVATION; REGULATOR
AB Metabolic syndrome (MetS) is a group of abnormal disorders; hypertension, glucose intolerance, dyslipidemia, proinflammatory, and prothrombotic states, affecting approximately 14 % of the world's population. The potential of grape seeds extract (GSE) supplementation to improve the metabolic disturbances and their related conditions like obesity, type 2 diabetes, and nonalcoholic fatty liver disease was investigated in this study. In-vitro metabolic syndrome assays were investigated through alpha-amylase, alpha-glucosidase, lipase, lipoxygenase (LOX), cyclooxygenases (COX-1 and COX-2), renin and angiotensin converting enzyme (ACE) inhibition assays. Additionally, in-vivo rat model of high-fat-high-carbohydrate diet (HFD)-induced MetS was established, where metformin (MT) (200 mg/kg) was used as a reference drug and GSE was given at 100 and 200 mg/kg by oral gavage. GSE was standardized using HPLC analysis for the major reported compound; catechin which should be >= 160.76 +/- 5.52 mu g/mL. Total phenolic content of GSE was 21.12 +/- 0.61 mu g gallic acid equivalent/1 mg extract and total flavonoid content was 23.81 +/- 0.64 mu g rutin equivalent/1 mg extract. In-vitro assays revealed the potential of GSE to manage the metabolic syndrome, besides its strong antioxidant capacity. Treatment with GSE (100 mg/kg and 200 mg/kg) markedly (P < 0.05) controlled the weight gain, improved the metabolic pathways (total glucose, cholesterol, triglycerides, AST, and ALT), oxidative stress parameters (MDA, GSH, and catalase) and inflammatory biomarkers in HFD fed rats. GSE downregulated the expression of insulin resistance gene (IR) and some inflammatory related genes (TNF-alpha and NF-kappa B), additionally it improved the pathological features of metabolic conditions and upgraded the expression of Nrf2 compared to HFD group. The superior effects were owned to the high dose of GSE, 200 mg/kg b.wt. (P < 0.05, P < 0.001). All results sustenance the beneficial effects of the standardized GSE in the management of metabolic syndrome. (c) 2024 SAAB. Published by Elsevier B.V. All rights reserved.
C1 [Mohamed, Salma Mostafa; Shalaby, Mostafa Abbas; Emam, Shimaa R.; El-Banna, Hossny A.] Cairo Univ, Fac Vet Med, Dept Pharmacol, Giza 12211, Egypt.
   [El-Shiekh, Riham A.] Cairo Univ, Fac Pharm, Dept Pharmacognosy, Cairo 11562, Egypt.
   [Bakr, Alaa F.] Cairo Univ, Fac Vet Med, Dept Pathol, Cairo, Egypt.
   [Rashad, Maha M.] Cairo Univ, Fac Vet Med, Dept Biochem & Mol Biol, Giza 12211, Egypt.
C3 Egyptian Knowledge Bank (EKB); Cairo University; Egyptian Knowledge Bank
   (EKB); Cairo University; Egyptian Knowledge Bank (EKB); Cairo
   University; Egyptian Knowledge Bank (EKB); Cairo University
RP El-Shiekh, RA (corresponding author), Cairo Univ, Fac Pharm, Dept Pharmacognosy, Cairo 11562, Egypt.
EM riham.adel@pharma.cu.edu.eg
RI El Banna, Hossny/AAV-5079-2020; R Emam, Shimaa/LQK-0944-2024; Shalaby,
   Drmostafa/S-9823-2019; rashad, maha/JZT-9552-2024
OI rashad, maha/0000-0001-7033-7440
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NR 71
TC 7
Z9 7
U1 1
U2 7
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0254-6299
EI 1727-9321
J9 S AFR J BOT
JI S. Afr. J. Bot.
PD APR
PY 2024
VL 167
BP 476
EP 486
DI 10.1016/j.sajb.2024.02.044
EA MAR 2024
PG 11
WC Plant Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences
GA OL7W5
UT WOS:001207503800001
DA 2025-06-11
ER

PT J
AU Yong, J
   Song, J
AF Yong, Jeongsik
   Song, Juhyun
TI CaMKII activity and metabolic imbalance-related neurological diseases:
   Focus on vascular dysfunction, synaptic plasticity, amyloid beta
   accumulation, and lipid metabolism
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Review
DE Metabolic syndromes (MetS); CaMKII; Neuropathology; Vascular
   dysfunction; Cognitive impairment
ID PROTEIN-KINASE-II; NITRIC-OXIDE SYNTHASE; BLOOD-BRAIN-BARRIER;
   DENSITY-LIPOPROTEIN CHOLESTEROL; CALMODULIN-BINDING PROTEINS; LONG-TERM
   POTENTIATION; ALZHEIMERS-DISEASE; FATTY-ACIDS; MICROVASCULAR
   DYSFUNCTION; MITOCHONDRIAL DYSFUNCTION
AB Metabolic syndrome (MetS) is characterized by insulin resistance, hyperglycemia, excessive fat accumulation and dyslipidemia, and is known to be accompanied by neuropathological symptoms such as memory loss, anxiety, and depression. As the number of MetS patients is rapidly increasing globally, studies on the mechanisms of metabolic imbalance-related neuropathology are emerging as an important issue. Ca2+/calmodulin-dependent kinase II (CaMKII) is the main Ca2+ sensor and contributes to diverse intracellular signaling in peripheral organs and the central nervous system (CNS). CaMKII exerts diverse functions in cells, related to mechanisms such as RNA splicing, reactive oxygen species (ROS) generation, cytoskeleton, and protein -protein interactions. In the CNS, CaMKII regulates vascular function, neuronal circuits, neurotransmission, synaptic plasticity, amyloid beta toxicity, lipid metabolism, and mitochondrial function. Here, we review recent evidence for the role of CaMKII in neuropathologic issues associated with metabolic disorders.
C1 [Yong, Jeongsik] Univ Minnesota Twin Cities, Dept Biochem Mol Biol & Biophys, Minneapolis, MN USA.
   [Song, Juhyun] Chonnam Natl Univ, Med Sch, Dept Anat, Hwasun 58128, Jeonranam Do, South Korea.
C3 University of Minnesota System; University of Minnesota Twin Cities;
   Chonnam National University
RP Song, J (corresponding author), Chonnam Natl Univ, Med Sch, Dept Anat, Hwasun 58128, Jeonranam Do, South Korea.
EM juhyunsong@chonnam.ac.kr
FU National Research Foundation of Korea (NRF) [NRF-2022R1A2C1006125];
   Chonnam National University Hwasun Hospital Institute for Biomedical
   Science Korea [HCRI24023]; National Institute of General Medical
   Sciences [5R01GM113952-08]
FX This study was supported by grant NRF-2022R1A2C1006125 from the National
   Research Foundation of Korea (NRF) and HCRI24023 from the Chonnam
   National University Hwasun Hospital Institute for Biomedical Science
   Korea for Juhyun Song, and National Institute of General Medical
   Sciences 5R01GM113952-08 for Jeongsik Yong.
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NR 223
TC 4
Z9 4
U1 0
U2 0
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD JUN
PY 2024
VL 175
AR 116688
DI 10.1016/j.biopha.2024.116688
EA APR 2024
PG 10
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA SS5A0
UT WOS:001236438400001
PM 38692060
OA gold
DA 2025-06-11
ER

PT J
AU Xu, D
   Zhang, C
   He, X
   Guo, ZJ
   Hu, DC
   Lu, J
   Cheng, SY
   Wang, H
AF Xu, Dan
   Zhang, Chong
   He, Xia
   Guo, Zijing
   Hu, Dongcai
   Lu, Juan
   Cheng, Siyuan
   Wang, Hui
TI High expression of hippocampal glutamic acid decarboxylase 67 mediates
   hypersensitivity of the hypothalamic-pituitary-adrenal axis in response
   to prenatal caffeine exposure in rats
SO TOXICOLOGY LETTERS
LA English
DT Article
DE Caffeine; Hypothalamic-pituitary-adrenal axis; Hypersensitivity;
   Hippocampus; Glutamic acid decarboxylase 67
ID CORTICOTROPIN-RELEASING HORMONE; METABOLIC SYNDROME;
   CARDIOVASCULAR-DISEASE; CHRONIC STRESS; SEMEN QUALITY; FETAL ORIGINS; C6
   CELLS; HPA-AXIS; RISK; CONSUMPTION
C1 [Xu, Dan; Zhang, Chong; He, Xia; Guo, Zijing; Hu, Dongcai; Lu, Juan; Cheng, Siyuan; Wang, Hui] Wuhan Univ, Basic Med Sch, Dept Pharmacol, Wuhan 430071, Hubei, Peoples R China.
   [Xu, Dan; Wang, Hui] Hubei Prov Key Lab Dev Originated Dis, Wuhan 430071, Hubei, Peoples R China.
   [Zhang, Chong] Hubei Univ Med, Xiangyang Peoples Hosp 1, Dept Pharm, Xiangyang 441000, Peoples R China.
C3 Wuhan University; Hubei University of Medicine
RP Xu, D; Wang, H (corresponding author), Wuhan Univ, Basic Med Sch, Dept Pharmacol, Wuhan 430071, Hubei, Peoples R China.
EM xuyidan70188@whu.edu.cn; wanghui19@whu.edu.cn
RI Hu, Dongcai/F-2375-2014; lu, juan/MEP-8121-2025; Cheng,
   Siyuan/HIR-2767-2022
FU National Natural Science Foundation of China [81220108026, 81430089,
   81371483, 81671472, 81673524]; Hubei Province Health and Family Planning
   Scientific Research Project [WJ2017C0003]
FX This work was supported by grants from the National Natural Science
   Foundation of China (Nos. 81220108026, 81430089, 81371483, 81671472,
   81673524) and Hubei Province Health and Family Planning Scientific
   Research Project (No. WJ2017C0003).
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NR 62
TC 12
Z9 13
U1 3
U2 18
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0378-4274
EI 1879-3169
J9 TOXICOL LETT
JI Toxicol. Lett.
PD FEB
PY 2018
VL 283
BP 39
EP 51
DI 10.1016/j.toxlet.2017.10.019
PG 13
WC Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Toxicology
GA FQ9BM
UT WOS:000418657300005
PM 29111460
DA 2025-06-11
ER

PT J
AU El-Zeftawy, M
   Ghareeb, D
   ElBealy, ER
   Saad, R
   Mahmoud, S
   Elguindy, N
   El-kott, AF
   El-Sayed, M
AF El-Zeftawy, Marwa
   Ghareeb, Doaa
   ElBealy, Eman R.
   Saad, Rasha
   Mahmoud, Salma
   Elguindy, Nihal
   El-kott, Attalla F.
   El-Sayed, Mohamed
TI Berberine chloride ameliorated PI3K/Akt-p/SIRT-1/PTEN signaling pathway
   in insulin resistance syndrome induced in rats
SO JOURNAL OF FOOD BIOCHEMISTRY
LA English
DT Article
DE berberine chloride; hepatotoxicity; insulin receptor; liver
ID TYPE-2 DIABETES-MELLITUS; BINDING-PROTEIN 4; HIGH-FAT DIET; OXIDATIVE
   STRESS; ADIPOSE-TISSUE; EXPRESSION; SIRT1; OBESITY; CHOLESTEROL;
   DYSFUNCTION
AB The liver is the main organ involved in lipid metabolism process and it helps in drug detoxification. Insulin resistance is considered one of risk reasons which lead to several metabolic diseases. Currently, berberine (BER) occupies a huge challenge against multiple diseases with no toxic effect. The present work was aimed to identify, does BER-chloride has a poisonous influence on the liver? and investigating the outcome of BER-chloride on PI3K/Akt-p/SIRT-1/PTEN pathway during insulin resistance syndrome. The insulin resistance model was achieved in experimental female rats via high-fat diet (HFD). Glucose, insulin, lipid profiles, and hepatic oxidative stress parameters were assessed. PI3K, AKt-p, SIRT-1, and PTEN levels in hepatic tissue were determined at genome and protein levels. Further adiponectin concentration was performed in serum, hepatic, and white adipose tissues. Molecular study of fold alteration in insulin, insulin receptor, and retinol binding protein-4 (RBP4) in liver was done. Practical applications Obesity syndrome causes multiple obstacles in modern years. The current results revealed elevation the body weight of rats, plasma glucose, homeostatic model assessment, glycated hemoglobin, insulin, and lipid profiles concentrations in a group of rats, which nourished HFD for 8 weeks and this rise, was diminished after 2 weeks from BER-chloride administration. Further, BER-chloride improved transaminases enzymes, pro-oxidant, and antioxidant defense system, PI3K, AKt-p, SIRT-1, and PTEN in the liver, with downregulation of hepatic RBP4. Hence, these data provide a crucial message that BER-chloride enhanced both hepatic function and insulin signaling pathways that might be of therapeutic importance to insulin resistance with no harmful effect on the liver. BER-chloride is predicted to be a drug of choice for obesity complications cure.
C1 [El-Zeftawy, Marwa] New Valley Univ, Fac Vet Med, Biochem Dept, New Valley, Egypt.
   [El-Zeftawy, Marwa; Ghareeb, Doaa; Saad, Rasha; Mahmoud, Salma] Alexandria Univ, Fac Sci, Biochem Dept, Biol Screening & Preclin Trial Lab, Alexandria, Egypt.
   [Ghareeb, Doaa] Gen Author City Sci Res & Technol Applicat, Pharmaceut & Fermentat Ind Dev Ctr, Alexandria, Egypt.
   [ElBealy, Eman R.] King Khalid Univ, Coll Sci Girls, Biol Dept, Abha, Saudi Arabia.
   [Elguindy, Nihal; El-Sayed, Mohamed] Alexandria Univ, Fac Sci, Biochem Dept, Alexandria, Egypt.
   [El-kott, Attalla F.] King Khalid Univ, Coll Sci, Biol Dept, Abha, Saudi Arabia.
   [El-kott, Attalla F.] Damanhour Univ, Coll Sci, Zool Dept, Damanhour, Egypt.
C3 Egyptian Knowledge Bank (EKB); Alexandria University; Imam Abdulrahman
   Bin Faisal University; King Khalid University; Egyptian Knowledge Bank
   (EKB); Alexandria University; King Khalid University; Egyptian Knowledge
   Bank (EKB); Damanhour University
RP El-Zeftawy, M (corresponding author), New Valley Univ, Fac Vet Med, Biochem Dept, New Valley, Egypt.
EM marwa@vetnv.au.edu.eg
RI ELSAYED, MOHAMED/AAG-6106-2020; Elbealy, Eman/HGA-3375-2022; El-Zeftawy,
   Marwa/AAR-1676-2021; El-kott, Attalla/D-1971-2017; Ghareeb,
   Doaa/R-6914-2016
OI Elguindy, Nihal/0000-0002-5705-1349; El-kott,
   Attalla/0000-0001-5060-0790; Ghareeb, Doaa/0000-0003-3327-4377;
   El-Zeftawy, Marwa/0000-0002-2884-8148
FU King Khalid University, Abha, KSA [R.G.P.1/117/40]
FX deanship of Scientific Research at King Khalid University, Abha, KSA for
   supported this work under grant number (R.G.P.1/117/40), Grant/Award
   Number: R.G.P.1/117/40
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NR 68
TC 22
Z9 23
U1 1
U2 35
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0145-8884
EI 1745-4514
J9 J FOOD BIOCHEM
JI J. Food Biochem.
PD DEC
PY 2019
VL 43
IS 12
AR e13049
DI 10.1111/jfbc.13049
EA SEP 2019
PG 11
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA LB1IL
UT WOS:000486267300001
PM 31512260
OA Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Tinkov, AA
   Bjorklund, G
   Skalny, AV
   Holmgren, A
   Skalnaya, MG
   Chirumbolo, S
   Aaseth, J
AF Tinkov, Alexey A.
   Bjorklund, Geir
   Skalny, Anatoly V.
   Holmgren, Arne
   Skalnaya, Margarita G.
   Chirumbolo, Salvatore
   Aaseth, Jan
TI The role of the thioredoxin/thioredoxin reductase system in the
   metabolic syndrome: towards a possible prognostic marker?
SO CELLULAR AND MOLECULAR LIFE SCIENCES
LA English
DT Review
DE Selenium; Thioredoxin reductase; Diabetes; Obesity; Thioredoxin
   interacting protein
ID THIOREDOXIN-INTERACTING PROTEIN; CELLULAR STRESS-RESPONSE; INCREASED
   PLASMA-LEVELS; FATTY LIVER-DISEASE; FACTOR-KAPPA-B; OXIDATIVE STRESS;
   ADIPOSE-TISSUE; SERUM THIOREDOXIN; ANGIOTENSIN-II; MITOCHONDRIAL
   THIOREDOXIN
AB Mammalian thioredoxin reductase (TrxR) is a selenoprotein with three existing isoenzymes (TrxR1, TrxR2, and TrxR3), which is found primarily intracellularly but also in extracellular fluids. The main substrate thioredoxin (Trx) is similarly found (as Trx1 and Trx2) in various intracellular compartments, in blood plasma, and is the cell's major disulfide reductase. Thioredoxin reductase is necessary as a NADPH-dependent reducing agent in biochemical reactions involving Trx. Genetic and environmental factors like selenium status influence the activity of TrxR. Research shows that the Trx/TrxR system plays a significant role in the physiology of the adipose tissue, in carbohydrate metabolism, insulin production and sensitivity, blood pressure regulation, inflammation, chemotactic activity of macrophages, and atherogenesis. Based on recent research, it has been reported that the modulation of the Trx/TrxR system may be considered as a new target in the management of the metabolic syndrome, insulin resistance, and type 2 diabetes, as well as in the treatment of hypertension and atherosclerosis. In this review evidence about a possible role of this system as a marker of the metabolic syndrome is reported.
C1 [Tinkov, Alexey A.; Skalny, Anatoly V.] Yaroslavl State Univ, Yaroslavl, Russia.
   [Tinkov, Alexey A.; Skalny, Anatoly V.; Skalnaya, Margarita G.] RUDN Univ, Peoples Friendship Univ Russia, Moscow, Russia.
   [Tinkov, Alexey A.] Russian Acad Sci, Inst Cellular & Intracellular Symbiosis, Orenburg, Russia.
   [Bjorklund, Geir] Council Nutr & Environm Med, Toften 24, N-8610 Mo I Rana, Norway.
   [Skalny, Anatoly V.] Trace Element Inst UNESCO, Lyon, France.
   [Skalny, Anatoly V.] Orenburg State Univ, Orenburg, Russia.
   [Holmgren, Arne] Karolinska Inst, Dept Med Biochem & Biophys MBB, Stockholm, Sweden.
   [Chirumbolo, Salvatore] Univ Verona, Dept Neurol & Movement Sci, Verona, Italy.
   [Aaseth, Jan] Innlandet Hosp Trust, Res Dept, Brumunddal, Norway.
   [Aaseth, Jan] Inland Norway Univ Appl Sci, Elverum, Norway.
C3 Yaroslavl State University; Peoples Friendship University of Russia;
   Russian Academy of Sciences; Orenburg Federal Research Center of the
   Ural Branch of the Russian Academy of Sciences; Institute of Cellular &
   Intracellular Symbiosis; Orenburg State University; Karolinska
   Institutet; University of Verona; Innlandet Hospital Trust; Inland
   Norway University of Applied Sciences
RP Bjorklund, G (corresponding author), Council Nutr & Environm Med, Toften 24, N-8610 Mo I Rana, Norway.
EM bjorklund@conem.org
RI Skalny, Anatoly/J-3953-2019; Chirumbolo, Salvatore/AGF-1981-2022;
   Aaseth, Jan/J-6764-2017; Chirumbolo, Salvatore/L-6865-2016; Bjorklund,
   Geir/B-7319-2014; Tinkov, Alexey/H-5842-2016
OI Chirumbolo, Salvatore/0000-0003-1789-8307; Bjorklund,
   Geir/0000-0003-2632-3935; Skalnaya, Margarita/0000-0003-1099-2560;
   Tinkov, Alexey/0000-0003-0348-6192; Skalny, Anatoly/0000-0001-7838-1366
FU Ministry of Education and Science of the Russian Federation on the
   program to improve the competitiveness of Peoples' Friendship University
   of Russia (RUDN University)
FX This paper was financially supported by the Ministry of Education and
   Science of the Russian Federation on the program to improve the
   competitiveness of Peoples' Friendship University of Russia (RUDN
   University) among the world's leading research and education centers in
   2016-2020.
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NR 246
TC 69
Z9 75
U1 3
U2 53
PU SPRINGER BASEL AG
PI BASEL
PA PICASSOPLATZ 4, BASEL, 4052, SWITZERLAND
SN 1420-682X
EI 1420-9071
J9 CELL MOL LIFE SCI
JI Cell. Mol. Life Sci.
PD MAY
PY 2018
VL 75
IS 9
BP 1567
EP 1586
DI 10.1007/s00018-018-2745-8
PG 20
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA GC6SI
UT WOS:000429922000006
PM 29327078
OA Green Published
DA 2025-06-11
ER

PT J
AU Zamani, A
   Sharifi, MH
   Fatemian, H
   Heiran, A
   Sedaghat, Z
   Yekta, EM
   Mirahmadizadeh, A
AF Zamani, A.
   Sharifi, M. H.
   Fatemian, H.
   Heiran, A.
   Sedaghat, Z.
   Yekta, E. mansouri
   Mirahmadizadeh, A.
TI Association between Sleep Quality and Metabolic Syndrome among
   Healthcare Workers in Southern Iran: A Cross-sectional Study
SO MEDICINE AND HEALTH
LA English
DT Article
DE Healthcare workers; metabolic syndrome; sleep quality
ID DISTURBANCES; DYSLIPIDEMIA; DEFINITION; DURATION; ADULTS; RISK
AB Sleep quality has emerged as a determinant of metabolic homeostasis. Healthcare workers (HCWs) exposed to occupational stress and demanding schedules, are vulnerable to sleep disturbances and metabolic dysregulation. We investigated the potential link between sleep quality and metabolic syndrome (MetS) among HCWs. A cross-sectional study was carried out using information from 5925 health workers in the SUMS Employee Health Cohort Study (SUMS EHCS), which was a branch of the PERSIAN cohort study launched by the Ministry of Health, Medicine, and Medical Education of Iran in 2013. MetS prevalence was 23.5% (ATP III) and 30.2% (IDF). 65.7% exhibited poor sleep quality. Univariable analysis showed associations between MetS (ATP III) and age, underlying disease and chronic stressors. In multivariable models, only underlying disease remained significant. Surprisingly, no significant association was found between MetS and sleep quality. Our findings suggest that underlying diseases and chronic stressors play a more substantial role in MetS among HCWs. While poor sleep quality is prevalent, it may not be an independent contributor to MetS in this cohort. Comprehensive interventions addressing multiple factors are crucial for HCW health. Longitudinal studies are essential to unravel the relationship between sleep quality, stress and metabolic health in this population.
C1 [Zamani, A.] Shiraz Univ Med Sci, Noncommunicable Dis Res Ctr, Dept Internal Med, Endocrinol & Metab, Shiraz, Iran.
   [Sharifi, M. H.] Shiraz Univ Med Sci, Res Ctr Tradit Med & Hist Med, Shiraz, Iran.
   [Fatemian, H.] Shiraz Univ Med Sci, Sch Med, Shiraz, Iran.
   [Heiran, A.; Yekta, E. mansouri; Mirahmadizadeh, A.] Shiraz Univ Med Sci, Noncommunicable Dis Res Ctr, Shiraz, Iran.
   [Sedaghat, Z.] Shahid Beheshti Univ Med Sci, Res Ctr, Sch Publ Hlth & Safety, Dept Epidemiol, Tehran, Iran.
C3 Shiraz University of Medical Science; Shiraz University of Medical
   Science; Shiraz University of Medical Science; Shiraz University of
   Medical Science; Shahid Beheshti University Medical Sciences
RP Mirahmadizadeh, A (corresponding author), Shiraz Univ Med Sci, Noncommunicable Dis Res Ctr, Shiraz, Iran.
EM mirahmadia@sums.ac.ir
RI heiran, alireza/ABB-3251-2020; Sharifi, Mohammad/V-7430-2018
FU Shiraz University of Medical Sciences, Shiraz, Iran
FX Shiraz University of Medical Sciences, Shiraz, Iran, financially
   supports this project.
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NR 44
TC 0
Z9 0
U1 0
U2 0
PU UNIV KEBANGSAAN MALAYSIA, FAC MEDICINE
PI KUALA LUMPUR
PA UNIV KEBANGSAAN MALAYSIA, FAC MEDICINE, KUALA LUMPUR, MALAYSIA
EI 2289-5728
J9 MED HEALTH-KUALA LUM
JI Med. Health
PD JAN
PY 2025
VL 20
IS 1
BP 281
EP 292
DI 10.17576/MH.2025.2001.17
PG 12
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA 0GI8V
UT WOS:001446715100017
OA gold
DA 2025-06-11
ER

PT J
AU Sulo, E
   Davidsen, ES
   Lonnebakken, MT
   Bleie, O
   Saeed, S
AF Sulo, Enxhela
   Davidsen, Einar Skulstad
   Lonnebakken, Mai Tone
   Bleie, Oyvind
   Saeed, Sahrai
TI Paradoxical sinus deceleration during dobutamine stress
   echocardiography: case series and review of the literature
SO EUROPEAN HEART JOURNAL-CASE REPORTS
LA English
DT Review
DE Dobutamine stress echocardiography; Paradoxical sinus deceleration; Case
   series
AB Background Dobutamine stress echocardiography is an established diagnostic modality for assessing myocardial ischaemia in patients with known or suspected coronary artery disease. Dobutamine infusion causes dose-dependent increase in heart rate and contractility. However, in some cases, it induces paradoxical sinus deceleration, whose underlying mechanism and clinical significance are not fully understood. Case summary We present episodes of paradoxical sinus deceleration observed during dobutamine stress echocardiography in six (four males and two females) patients and described its patterns of occurrence and clinical and echocardiographic characteristics. Discussion Paradoxical sinus deceleration occurred mostly at maximal dobutamine infusion was accompanied with a decline in blood pressure and resolved spontaneously following cessation of dobutamine infusion. Individuals experiencing paradoxical sinus deceleration had in common abnormal left ventricle geometry but differed with regard to age, sex, and cardiometabolic risk factors.
C1 [Sulo, Enxhela; Davidsen, Einar Skulstad; Lonnebakken, Mai Tone; Bleie, Oyvind; Saeed, Sahrai] Haukeland Hosp, Dept Heart Dis, Bergen, Norway.
   [Lonnebakken, Mai Tone] Univ Bergen, Dept Clin Sci, Bergen, Norway.
C3 University of Bergen; Haukeland University Hospital; University of
   Bergen
RP Sulo, E (corresponding author), Haukeland Hosp, Dept Heart Dis, Bergen, Norway.
EM Enxhela.Sulo@helse-bergen.no
RI Lonnebakken, Mai/AAL-2328-2021
OI Lonnebakken, Mai Tone/0000-0002-5600-8859; Bleie,
   Oyvind/0000-0002-7842-8707; Saeed, Sahrai/0000-0003-4041-5019
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NR 14
TC 3
Z9 3
U1 0
U2 2
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
EI 2514-2119
J9 EUR HEART J-CASE REP
JI Eur. Heart J.-Case Rep.
PD OCT 8
PY 2022
VL 6
IS 10
AR ytac180
DI 10.1093/ehjcr/ytac180
EA OCT 2022
PG 7
WC Cardiac & Cardiovascular Systems
WE Emerging Sources Citation Index (ESCI)
SC Cardiovascular System & Cardiology
GA 5N3EP
UT WOS:000871673100002
PM 36420417
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Kaimul, AM
   Nakamura, H
   Masutani, H
   Yodoi, J
AF Kaimul, Ahsan M.
   Nakamura, Hajime
   Masutani, Hiroshi
   Yodoi, Junji
TI Thioredoxin and thioredoxin-binding protein-2 in cancer and metabolic
   syndrome
SO FREE RADICAL BIOLOGY AND MEDICINE
LA English
DT Review
DE thioredoxin; redox; antioxidant; thioredoxin-binding protein-2; cancer;
   metabolism; free radicals
ID UP-REGULATED PROTEIN-1; LEUKEMIA-DERIVED FACTOR; SUBEROYLANILIDE
   HYDROXAMIC ACID; HISTONE DEACETYLASE INHIBITOR; AUTOCRINE GROWTH-FACTOR;
   VIRUS TYPE-I; OXIDATIVE STRESS; INTERACTING PROTEIN; SERUM THIOREDOXIN;
   GENE-EXPRESSION
AB Thioredoxin (TRX), a small redox-active multifunctional protein, acts as a potent antioxidant and a redox regulator in signal transduction. TRX expression is elevated in various types of human cancer. Overexpression of TRX introduces resistance to anti-cancer drugs or radiation-induced apoptosis; however, there is no evidence that the incidence of cancer is frequent in TRX-transgenic mice or that the administration of recombinant human TRX enhances tumor growth. Plasma/serum level of TRX is a good marker for oxidative stress-induced various disorders, including metabolic syndrome. Thioredoxin-binding protem-2 (TBP-2), which was originally identified as a negative regulator of TRX, acts as a growth suppressor and a regulator in lipid metabolism. TBP-2 expression is downregulated in various types of human cancer. TBP-2 deficiency induces lipid dysfunction and a phenotype resembling Reye syndrome. Thus, TRX and TBP-2 play important roles in the pathophysiology of cancer and metabolic syndrome by direct interaction or by independent mechanisms. (c) 2007 Published by Elsevier Inc.
C1 Kyoto Univ, Dept Biol Responses, Inst Virus Res, Lab Infect & Prevent,Sakyo Ku, Kyoto 6068507, Japan.
   Kyoto Univ Hosp, Translat Res Ctr, Dept Expt Therapeut, Thioredoxin Project, Kyoto 6068507, Japan.
C3 Kyoto University; Kyoto University
RP Yodoi, J (corresponding author), Kyoto Univ, Dept Biol Responses, Inst Virus Res, Lab Infect & Prevent,Sakyo Ku, 53 Shogoin, Kyoto 6068507, Japan.
EM yodoi@virus.kyoto-u.ac.jp
RI Yodoi, Junji/F-6189-2011; Masutani, Hiroshi/B-5114-2014
OI Masutani, Hiroshi/0000-0001-7633-2827
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NR 104
TC 111
Z9 127
U1 0
U2 8
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0891-5849
EI 1873-4596
J9 FREE RADICAL BIO MED
JI Free Radic. Biol. Med.
PD SEP 15
PY 2007
VL 43
IS 6
BP 861
EP 868
DI 10.1016/j.freeradbiomed.2007.05.032
PG 8
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 206NP
UT WOS:000249190500001
PM 17697931
DA 2025-06-11
ER

PT J
AU Evans, JL
   Youngren, JF
   Goldfine, ID
AF Evans, JL
   Youngren, JF
   Goldfine, ID
TI Effective treatments for insulin resistance: trim the fat and douse the
   fire
SO TRENDS IN ENDOCRINOLOGY AND METABOLISM
LA English
DT Review
ID PROLIFERATOR-ACTIVATED RECEPTORS; ALPHA-LIPOIC ACID; TYPE-2
   DIABETES-MELLITUS; PEROXISOME-PROLIFERATOR; METABOLIC SYNDROME;
   OXIDATIVE STRESS; SKELETAL-MUSCLE; PROTEIN-KINASE; PPAR-GAMMA;
   LIPID-METABOLISM
AB Currently, only limited treatments are available for insulin resistance, a major cause of type 2 diabetes (T2D) and the metabolic syndrome. Combined innovative pharmaceutical and non-pharmaceutical strategies are needed. Obesity, a major cause of insulin resistance in T2D, can be treated relatively safely with modern bariatric surgery. Exercise training to increase VO2max is an important non-pharmaceutical approach to decrease insulin resistance. The thiazolidinediones are useful in treating insulin resistance, but newer agents with broader specificity might be more efficacious without deleterious side effects. Recently oxidative stress has been implicated in insulin resistance. One antioxidant that is safe and appears effective is alpha-lipoic acid. Thus, combinations of surgery, exercise training, insulin sensitizers and antioxidants will probably constitute future insulin resistance management.
C1 Med Res Inst, San Francisco, CA 94107 USA.
   Univ Calif San Francisco, San Francisco, CA 94143 USA.
C3 University of California System; University of California San Francisco
RP Med Res Inst, San Francisco, CA 94107 USA.
EM evansphd@earthlink.net
RI Evans, Joseph/N-4501-2013
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NR 82
TC 21
Z9 22
U1 0
U2 1
PU ELSEVIER SCIENCE LONDON
PI LONDON
PA 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND
SN 1043-2760
EI 1879-3061
J9 TRENDS ENDOCRIN MET
JI Trends Endocrinol. Metab.
PD NOV
PY 2004
VL 15
IS 9
BP 425
EP 431
DI 10.1016/j.tem.2004.09.005
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 872WR
UT WOS:000225240400004
PM 15519889
DA 2025-06-11
ER

PT J
AU Guenther, L
   Gulliver, W
AF Guenther, Lyn
   Gulliver, Wayne
TI Psoriasis Comorbidities
SO JOURNAL OF CUTANEOUS MEDICINE AND SURGERY
LA English
DT Review
ID NECROSIS-FACTOR-ALPHA; C-REACTIVE PROTEIN; CORONARY-HEART-DISEASE;
   RISK-FACTORS; CARDIOVASCULAR-DISEASE; LONG-TERM; MYOCARDIAL-INFARCTION;
   RHEUMATOID-ARTHRITIS; INFLIXIMAB TREATMENT; ALCOHOL-CONSUMPTION
AB Psoriasis has been associated with a number of behavioral and systemic comorbidities, including psoriatic arthritis, anxiety, depression, obesity, hypertension, diabetes mellitus, hyperlipidemia, metabolic syndrome, smoking, cardiovascular disease, alcoholism, Crohn's disease, lymphoma, and multiple sclerosis. Many of these conditions have a similar immunologic pathogeneses. Canadian and international studies have not only confirmed the presence of these comorbidities but also have demonstrated that patients with psoriasis have a significantly reduced life span. Given that patients with psoriasis are often unaware of their comorbidities, they should be screened for these conditions and treated if required by their dermatologist and/or primary care physician. It is important to keep in mind that the comorbidities and drugs used to treat them have an impact on the choice of anti-psoriatic treatment. In addition, comorbidities often preclude the use of traditional systemic agents. Recent studies have demonstrated that patients with preexisting comorbidities can be safely and effectively treated with biologic therapy. Furthermore, literature is evolving to suggest that better control of psoriasis might decrease cardiovascular mortality and prolong life.
C1 [Guenther, Lyn] Guenther Dermatol Res Ctr, London, ON N6A 3H7, Canada.
   [Gulliver, Wayne] Mem Univ Newfoundland, Fac Med, St John, NF, Canada.
C3 Memorial University Newfoundland
RP Guenther, L (corresponding author), Guenther Dermatol Res Ctr, 835 Richmond St, London, ON N6A 3H7, Canada.
EM dgue@gdrc.ca
RI Gulliver, Professor Wayne/ACM-2713-2022
FU Arbor Communications, Inc.
FX Financial disclosure of authors: Dr. Guenther has been a clinical
   investigator, consultant, advisory board member and speaker for Abbott
   Laboratories, Amgen, Astellas, Biogen Idec, EMD Serono, Galderma,
   Isotechnika, Janssen-Ortho, Leo Pharma, Ortho Biotech, Novartis, and
   Schering-Plough. Dr. Guenther has been a consultant, advisory board
   member and speaker for Wyeth, and a clinical investigator, consultant
   and advisory board member for Centocor. Dr. Gulliver has been an
   investigator for Barrier, Basilea, EMD Serono, Galderina,
   GlaxoSmithKline, Global, Johnson & Johnson, Leo Pharma, Pfizer, Redox,
   and Stiefel Canada, Inc. Funding for manuscript development was provided
   by Abbott Laboratories, with editorial support provided by Arbor
   Communications, Inc.Financial disclosure of reviewers: None reported.
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NR 129
TC 29
Z9 31
U1 0
U2 2
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1203-4754
EI 1615-7109
J9 J CUTAN MED SURG
JI J. Cutan. Med. Surg.
PD SEP-OCT
PY 2009
VL 13
SU 2
BP S77
EP S87
DI 10.2310/7750.2009.00024
PG 11
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 506ZL
UT WOS:000270818500004
PM 19799830
DA 2025-06-11
ER

PT J
AU Borska, L
   Kremlacek, J
   Andrys, C
   Krejsek, J
   Hamakova, K
   Borsky, P
   Palicka, V
   Rehacek, V
   Malkova, A
   Fiala, Z
AF Borska, Lenka
   Kremlacek, Jan
   Andrys, Ctirad
   Krejsek, Jan
   Hamakova, Kvetoslava
   Borsky, Pavel
   Palicka, Vladimir
   Rehacek, Vit
   Malkova, Andrea
   Fiala, Zdenek
TI Systemic Inflammation, Oxidative Damage to Nucleic Acids, and Metabolic
   Syndrome in the Pathogenesis of Psoriasis
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE psoriasis; inflammation; oxidative stress; metabolic syndrome
ID C-REACTIVE PROTEIN; POPULATION; ASSOCIATION; PREVALENCE; PROFILE; RISK;
   DNA
AB In the pathogenesis of psoriasis, systemic inflammation and oxidative stress play mutual roles interrelated with metabolic syndrome (MetS). This study aims to map the selected markers of inflammation (C-reactive protein (CRP)), oxidative damage to nucleic acids (DNA/RNA damage; 8-hydroxy-2-deoxyguanosine, 8-hydroxyguanosine, and 8-hydroxyguanine), and the parameters of MetS (waist circumference, fasting glucose, triglycerides, high-density lipoprotein (HDL) cholesterol, diastolic and systolic blood pressure) in a group of 37 patients with psoriasis (62% of MetS) and in 43 healthy controls (42% of MetS). Levels of CRP, DNA/RNA damage, fasting glucose, and triglycerides were significantly elevated in patients. MetS in conjunction with psoriasis was associated with high levels of CRP, significantly higher than in control subjects without MetS. Patients with MetS exhibited further DNA/RNA damage, which was significantly higher in comparison with the control group. Our study supports the independent role of psoriasis and MetS in the increase of CRP and DNA/RNA damage. The psoriasis contributes to an increase in the levels of both effects more significantly than MetS. The psoriasis also diminished the relationship between CRP and oxidative damage to nucleic acids existent in controls.
C1 [Borska, Lenka; Kremlacek, Jan; Borsky, Pavel] Charles Univ Prague, Fac Med Hradec Kralove, Dept Pathol Physiol, Hradec Kralove 50003, Czech Republic.
   [Andrys, Ctirad; Krejsek, Jan] Charles Univ Prague, Fac Med Hradec Kralove, Dept Clin Immunol & Allergol, Hradec Kralove 50003, Czech Republic.
   [Hamakova, Kvetoslava] Charles Univ Hosp Hradec Kralove, Clin Dermal & Venereal Dis, Hradec Kralove 50005, Czech Republic.
   [Palicka, Vladimir] Charles Univ Hosp, Inst Clin Biochem & Diagnost, Hradec Kralove 50005, Czech Republic.
   [Palicka, Vladimir] Fac Med Hradec Kralove, Hradec Kralove 50005, Czech Republic.
   [Rehacek, Vit] Charles Univ Hosp Hradec Kralove, Dept Transfus Med, Hradec Kralove 50005, Czech Republic.
   [Malkova, Andrea; Fiala, Zdenek] Charles Univ Prague, Fac Med Hradec Kralove, Dept Hyg & Prevent Med, Hradec Kralove 50003, Czech Republic.
C3 Charles University Prague; University Hospital Hradec Kralove;
   University Hospital Hradec Kralove; Charles University Prague; Charles
   University Prague; University Hospital Hradec Kralove; Charles
   University Prague; University Hospital Hradec Kralove; University
   Hospital Hradec Kralove; Charles University Prague; University Hospital
   Hradec Kralove; Charles University Prague; University Hospital Hradec
   Kralove; Charles University Prague
RP Borska, L (corresponding author), Charles Univ Prague, Fac Med Hradec Kralove, Dept Pathol Physiol, Hradec Kralove 50003, Czech Republic.
EM borka@lfhk.cuni.cz; kremlack@lfhk.cuni.cz; andrys@lfhk.cuni.cz;
   KrejsekJ@lfhk.cuni.cz; kveta.hamakova@fnhk.cz; BORSKYP@lfhk.cuni.cz;
   vladimir.palicka@fnhk.cz; vit.rehacek@fnhk.cz; malka8ar@lfhk.cuni.cz;
   fiala@lfhk.cuni.cz
RI Palicka, Vladimir/N-1802-2017; Krejsek, Jan/AAQ-6561-2021; Fiala,
   Zdeněk/E-5962-2017; Malkova, Andrea/B-1013-2017; Rehacek,
   Vit/H-4564-2018; Kremlacek, Jan/A-4313-2008; Borsky, Pavel/S-6307-2016;
   Borska, Lenka/S-6304-2016
OI Malkova, Andrea/0000-0001-9444-8065; Rehacek, Vit/0000-0003-1958-1207;
   Kremlacek, Jan/0000-0001-8641-4287; Borsky, Pavel/0000-0001-5253-2808;
   Andrys, Ctirad/0000-0001-6489-8786; Borska, Lenka/0000-0002-8580-1485
FU Charles University in Prague, Faculty of Medicine in Hradec Kralove,
   Czech Republic [PROGRES Q40-09, PROGRES Q40-10, SVV-260397 / 2017]
FX Charles University in Prague, Faculty of Medicine in Hradec Kralove,
   Czech Republic, project PROGRES Q40-09, PROGRES Q40-10 and SVV-260397 /
   2017 supported the study. The authors acknowledge and thank to Dana
   Knajflova (certified proofreader, M.A., Hradec Kralove, Czech Republic)
   for proofreading the text and helping with linguistics.
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NR 37
TC 39
Z9 40
U1 0
U2 11
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD NOV
PY 2017
VL 18
IS 11
AR 2238
DI 10.3390/ijms18112238
PG 12
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA FO4KK
UT WOS:000416811300012
PM 29068430
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Bigi, R
   De Chiara, B
AF Bigi, R
   De Chiara, B
TI Prognostic value of noninvasive stressing modalities in patients with
   chest pain and normal coronary angiogram
SO HERZ
LA English
DT Article
DE stress test; syndrome X; normal coronary angiogram; myocardial ischemic;
   autonome dysfunction
ID TERM-FOLLOW-UP; DIPYRIDAMOLE-ECHOCARDIOGRAPHY TEST; LEFT-VENTRICULAR
   FUNCTION; CARDIAC SYNDROME-X; ARTERY-DISEASE; RISK STRATIFICATION;
   ANGINA-PECTORIS; ENDOTHELIAL DYSFUNCTION; MYOCARDIAL-ISCHEMIA; EXERCISE
AB Risk stratification of patients with recurrent chest pain and normal coronary angiogram is a relevant but still definitely unsolved clinical problem. In this article the relative value of mostly used noninvasive stress testing modalities is reviewed. In addition, future perspectives derived from alternative pathophysiological insights and new diagnostic approaches are briefly discussed.
C1 Univ Milan, Sch Med, Dept Med & Surg, Milan, Italy.
C3 University of Milan
RP Univ Milan, Sch Med, S Paolo Acad Hosp, Dept Med & Surg, Via A Rudini 8, I-20142 Milan, Italy.
EM Riccardo.Bigi@unimi.it
RI de chiara, benedetta/AAE-5322-2022
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NR 47
TC 3
Z9 5
U1 0
U2 0
PU URBAN & VOGEL
PI MUNICH
PA NEUMARKTER STRASSE 43, D-81673 MUNICH, GERMANY
SN 0340-9937
EI 1615-6692
J9 HERZ
JI Herz
PD FEB
PY 2005
VL 30
IS 1
BP 61
EP 66
DI 10.1007/s00059-005-2640-6
PG 6
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 906NQ
UT WOS:000227649300009
PM 15754157
DA 2025-06-11
ER

PT J
AU Wolf, EJ
   Schnurr, PP
AF Wolf, Erika J.
   Schnurr, Paula P.
TI Posttraumatic Stress Disorder-Related Cardiovascular Disease and
   Accelerated Cellular Aging
SO PSYCHIATRIC ANNALS
LA English
DT Article
ID MAJOR DEPRESSIVE DISORDER; DNA METHYLATION AGE; METABOLIC SYNDROME;
   PHYSICAL-ACTIVITY; RISK; ASSOCIATIONS; COMPONENTS; PROFILES; PEOPLE
AB We reviewed the literature from 2010 to 2016 on the relationship between posttraumatic stress disorder (PTSD) and cardiometabolic health conditions, including metabolic syndrome, coronary artery disease, stroke, and myocardial infarction, among others. Collectively, PTSD was associated with increased risk of cardiometabolic health problems, with preclinical and clinical studies offering evidence of behavioral (eg, poor sleep, cigarette use, poor diet, and insufficient exercise) and biological (eg, autonomic reactivity, inflammation) mediators of these associations. We discuss the possibility that these behavioral and biological mechanisms lead to accelerated cellular aging, as regulated in the epigenome, which contributes to premature cardiometabolic health decline. This has implications for the assessment, prevention, and treatment of cardiometabolic conditions among those with PTSD. It also highlights the need to better understand the mechanisms linking PTSD to accelerated aging and to develop interventions to attenuate or reverse this phenomenon.
C1 [Wolf, Erika J.] VA Boston Healthcare Syst, Natl Ctr PTSD, Boston, MA USA.
   [Wolf, Erika J.] Boston Univ, Sch Med, Dept Psychiat, Boston, MA 02215 USA.
   [Schnurr, Paula P.] Natl Ctr PTSD, Boston, MA USA.
   [Schnurr, Paula P.] Dartmouth Coll, Geisel Sch Med, Psychiat, Dartmouth, NS, Canada.
C3 Harvard University; Harvard University Medical Affiliates; US Department
   of Veterans Affairs; Veterans Health Administration (VHA); VA Boston
   Healthcare System; Boston University; Harvard University; Harvard
   University Medical Affiliates; US Department of Veterans Affairs;
   Veterans Health Administration (VHA); VA Boston Healthcare System
RP Wolf, EJ (corresponding author), VA Boston Healthcare Syst 116B 2, Natl Ctr PTSD, 150 South Huntington Ave, Boston, MA 02130 USA.
EM erika.wolf@va.gov
OI Wolf, Erika/0000-0003-2666-2435; Schnurr, Paula/0000-0002-6195-716X
FU United States Department of Veterans Affairs, Clinical Sciences Research
   and Development Program
FX This work was supported by a Career Development Award to E.J.W. from the
   United States Department of Veterans Affairs, Clinical Sciences Research
   and Development Program.
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NR 37
TC 53
Z9 60
U1 1
U2 9
PU SLACK INC
PI THOROFARE
PA 6900 GROVE RD, THOROFARE, NJ 08086 USA
SN 0048-5713
EI 1938-2456
J9 PSYCHIAT ANN
JI Psychiatr. Ann.
PD SEP
PY 2016
VL 46
IS 9
BP 527
EP 532
DI 10.3928/00485713-20160729-01
PG 6
WC Psychiatry
WE Social Science Citation Index (SSCI)
SC Psychiatry
GA EC9EY
UT WOS:000388448400007
PM 27990033
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Antoniotti, V
   Bellone, S
   Correia, FPG
   Peri, C
   Tini, S
   Ricotti, R
   Mancioppi, V
   Gagliardi, M
   Spadaccini, D
   Caputo, M
   Corazzari, M
   Prodam, F
AF Antoniotti, Valentina
   Bellone, Simonetta
   Correia, Filipa Patricia Goncalves
   Peri, Caterina
   Tini, Sabrina
   Ricotti, Roberta
   Mancioppi, Valentina
   Gagliardi, Mara
   Spadaccini, Daniele
   Caputo, Marina
   Corazzari, Marco
   Prodam, Flavia
TI Calreticulin and PDIA3, two markers of endoplasmic reticulum stress, are
   associated with metabolic alterations and insulin resistance in
   pediatric obesity: A pilot study
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Article
DE obesity; ER stress; pediatrics; insulin; lipids
ID ADIPOSE-TISSUE; PROTEOMIC ANALYSIS; ER-STRESS; OVERWEIGHT; PROTEIN;
   EXPRESSION; ERP57; IDENTIFICATION; INFLAMMATION; HEALTH
AB Our aim was to evaluate the markers of endoplasmic reticulum (ER) stress among children and adolescents with obesity in relation to metabolic alterations. Calreticulin (CALR) and PDIA3 circulating levels were assessed on 52 pediatric subjects-26 patients with obesity and 26 normal weight controls (4-18 years)-enrolled in a pilot study. Clinical and metabolic evaluations were performed (BMI-SDS, insulin, and glucose at fasting and during an oral glucose tolerance test, lipid profile, blood pressure), and metabolic syndrome was detected. PDIA3 was higher (p < 0.02) and CALR slightly higher in children with obesity than in controls. PDIA3 was related positively to the Tanner stages. Both PDIA3 and CALR were positively associated with insulin resistance, cholesterol, and triglycerides and the number of criteria identifying metabolic syndrome and negatively with fasting and post-challenge insulin sensitivity. Our preliminary findings suggest the existence of a link between ER stress and metabolic changes behind obesity complications even at the pediatric age. CALR and PDIA3 could be early markers of insulin resistance and dyslipidemia-related ER stress useful to stratify patients at high risk of further complications.
C1 [Antoniotti, Valentina; Bellone, Simonetta; Peri, Caterina; Ricotti, Roberta; Mancioppi, Valentina] Univ Piemonte Orientale, Dept Hlth Sci, Struttura Complessa Direz Universitaria SCDU Pedia, Novara, Italy.
   [Correia, Filipa Patricia Goncalves; Tini, Sabrina; Gagliardi, Mara; Spadaccini, Daniele; Caputo, Marina; Corazzari, Marco; Prodam, Flavia] Univ Piemonte Orientale, Dept Hlth Sci, Novara, Italy.
   [Gagliardi, Mara; Corazzari, Marco] Univ Piemonte Orientale, Ctr Translat Res Autoimmune & Allerg Dis CAAD, Novara, Italy.
   [Caputo, Marina; Prodam, Flavia] Univ Piemonte Orientale, Interdisciplinary Res Ctr Autoimmune Dis IRCAD, Novara, Italy.
   [Caputo, Marina; Prodam, Flavia] Univ Piemonte Orientale, Dept Translat Med, Endocrinol, Novara, Italy.
C3 University of Eastern Piedmont Amedeo Avogadro; University of Eastern
   Piedmont Amedeo Avogadro; University of Eastern Piedmont Amedeo
   Avogadro; University of Eastern Piedmont Amedeo Avogadro; University of
   Eastern Piedmont Amedeo Avogadro
RP Corazzari, M; Prodam, F (corresponding author), Univ Piemonte Orientale, Dept Hlth Sci, Novara, Italy.; Corazzari, M (corresponding author), Univ Piemonte Orientale, Ctr Translat Res Autoimmune & Allerg Dis CAAD, Novara, Italy.; Prodam, F (corresponding author), Univ Piemonte Orientale, Interdisciplinary Res Ctr Autoimmune Dis IRCAD, Novara, Italy.; Prodam, F (corresponding author), Univ Piemonte Orientale, Dept Translat Med, Endocrinol, Novara, Italy.
EM marco.corazzari@uniupo.it; flavia.prodam@med.uniupo.it
RI Prodam, Flavia/B-8844-2013; Gagliardi, Mara/AAK-4742-2020; Corazzari,
   Marco/J-5825-2019; Antoniotti, Valentina/AAA-8131-2022; Spadaccini,
   Daniele/KHD-9965-2024; Caputo, Marina/AAC-6707-2022; Bellone,
   Simonetta/K-2196-2016
OI Prodam, Flavia/0000-0001-9660-5335; mancioppi,
   valentina/0000-0002-4241-0118; Gagliardi, Mara/0000-0002-3222-790X;
   Tini, Sabrina/0009-0004-6593-0054
FU Department of Excellence grant; Ministry of Education, Universities, and
   Research (MUR) [2020NCKXBR_004]; DMPREVENT project and Universita del
   Piemonte Orientale
FX This research was partially supported by a Department of Excellence
   grant (FOHN project, KE-TOMI project) and PRIN grant (2020NCKXBR_004;
   SIDERALE Project) from the Ministry of Education, Universities, and
   Research (MUR), DMPREVENT project and Universita del Piemonte Orientale
   (FAR-2016).
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NR 43
TC 7
Z9 8
U1 1
U2 2
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD SEP 23
PY 2022
VL 13
AR 1003919
DI 10.3389/fendo.2022.1003919
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 5P3HI
UT WOS:000873045300001
PM 36213269
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Shenoy, SF
   Poston, WSC
   Reeves, RS
   Kazaks, AG
   Holt, RR
   Keen, CL
   Chen, HJ
   Haddock, CK
   Winters, BL
   Khoo, CSH
   Foreyt, JP
AF Shenoy, Sonia F.
   Poston, Walker S. C.
   Reeves, Rebecca S.
   Kazaks, Alexandra G.
   Holt, Roberta R.
   Keen, Carl L.
   Chen, Hsin Ju
   Haddock, C. Keith
   Winters, Barbara L.
   Khoo, Chor San H.
   Foreyt, John P.
TI Weight loss in individuals with metabolic syndrome given DASH diet
   counseling when provided a low sodium vegetable juice: a randomized
   controlled trial
SO NUTRITION JOURNAL
LA English
DT Article
ID LIFE-STYLE MODIFICATION; C-REACTIVE PROTEIN; TOMATO EXTRACT;
   PLATELET-FUNCTION; RISK-FACTORS; FRUIT; INTERVENTION; CONSUMPTION;
   PREDICTORS; EDUCATION
AB Background: Metabolic syndrome, a constellation of metabolic risk factors for type 2 diabetes and cardiovascular disease, is one of the fastest growing disease entities in the world. Weight loss is thought to be a key to improving all aspects of metabolic syndrome. Research studies have suggested benefits from diets rich in vegetables and fruits in helping individuals reach and achieve healthy weights.
   Objective: To evaluate the effects of a ready to serve vegetable juice as part of a calorie-appropriate Dietary Approaches to Stop Hypertension (DASH) diet in an ethnically diverse population of people with Metabolic Syndrome on weight loss and their ability to meet vegetable intake recommendations, and on their clinical characteristics of metabolic syndrome (waist circumference, triglycerides, HDL, fasting blood glucose and blood pressure).
   A secondary goal was to examine the impact of the vegetable juice on associated parameters, including leptin, vascular adhesion markers, and markers of the oxidative defense system and of oxidative stress.
   Methods: A prospective 12 week, 3 group (0, 8, or 16 fluid ounces of low sodium vegetable juice) parallel arm randomized controlled trial. Participants were requested to limit their calorie intake to 1600 kcals for women and 1800 kcals for men and were educated on the DASH diet. A total of 81 (22 men & 59 women) participants with Metabolic Syndrome were enrolled into the study. Dietary nutrient and vegetable intake, weight, height, leptin, metabolic syndrome clinical characteristics and related markers of endothelial and cardiovascular health were measured at baseline, 6-, and 12-weeks.
   Results: There were significant group by time interactions when aggregating both groups consuming vegetable juice (8 or 16 fluid ounces daily). Those consuming juice lost more weight, consumed more Vitamin C, potassium, and dietary vegetables than individuals who were in the group that only received diet counseling (p < 0.05).
   Conclusion: The incorporation of vegetable juice into the daily diet can be a simple and effective way to increase the number of daily vegetable servings. Data from this study also suggest the potential of using a low sodium vegetable juice in conjunction with a calorie restricted diet to aid in weight loss in overweight individuals with metabolic syndrome.
C1 [Shenoy, Sonia F.; Holt, Roberta R.; Keen, Carl L.; Chen, Hsin Ju] Univ Calif Davis, Dept Nutr, Davis, CA 95616 USA.
   [Poston, Walker S. C.; Haddock, C. Keith] NDRI, Inst Biobehav Hlth Res, Leawood, KS USA.
   [Reeves, Rebecca S.; Foreyt, John P.] Baylor Coll Med, Dept Med, Houston, TX 77030 USA.
   [Kazaks, Alexandra G.] Bastyr Univ, Dept Nutr & Exercise Sci, Kenmore, WA USA.
   [Keen, Carl L.] Univ Calif Davis, Dept Internal Med, Davis, CA 95616 USA.
   [Winters, Barbara L.; Khoo, Chor San H.] Campbell Soup Co, Camden, NJ USA.
C3 University of California System; University of California Davis; Baylor
   College of Medicine; University of California System; University of
   California Davis
RP Shenoy, SF (corresponding author), Univ Calif Davis, Dept Nutr, Davis, CA 95616 USA.
EM sfshenoy@ucdavis.edu
RI Holt, Roberta/P-7710-2019
FU Campbell Soup Company
FX This work was supported by resources from the Campbell Soup Company. CS
   Khoo and BL Winters are employees of Campbell Soup Company and hold
   stock there. CL Keen and JP Foreyt are members of Campbell Soup
   Company's Vegetable Plant Advisory Panel. SF Shenoy, WSC Poston, RS
   Reeves, AG Kazaks, RR Holt, HJ Chen, CK Haddock do not have any
   financial interests to declare.
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NR 61
TC 33
Z9 41
U1 0
U2 19
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1475-2891
J9 NUTR J
JI Nutr. J.
PD FEB 23
PY 2010
VL 9
AR 8
DI 10.1186/1475-2891-9-8
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nutrition & Dietetics
GA 574CP
UT WOS:000275966300001
PM 20178625
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Dhar, S
   Srinivas, S
AF Dhar, Sandipan
   Srinivas, Sahana
TI Psoriasis in pediatric age group
SO INDIAN JOURNAL OF DERMATOLOGY
LA English
DT Article
DE Childhood; current aspects; management; proactive therapy; psoriasis
ID CHILDHOOD PSORIASIS; PLAQUE PSORIASIS; TONSILLECTOMY; EPIDEMIOLOGY;
   CHILDREN; COMORBIDITY; HLA-CW6; PATIENT; SAFETY
AB Psoriasis is a common, chronic, immune-mediated, multisystem, inflammatory disorder. It affects all age groups, including infancy. In one-third of the cases, the onset of the disease is in the first and second decades of life. Childhood psoriasis significantly affects the quality of life of the child as well as that of the entire family. Pediatric psoriasis has distinct clinical presentations and evolves with time. Like in adults, chronic plaque psoriasis has been found to be the most common type of childhood psoriasis. Psoriatic plaques in children are less pruritic, smaller and thinner with less prominent scaling. In pigmented skin, the erythema is less prominent and plaques appear violaceous or hyperpigmented. Pediatric psoriasis can be associated with arthritis, metabolic syndrome, depression and anxiety. Hence all children should be screened routinely for associated comorbidities. Management of pediatric psoriasis is challenging owing to the limitation of approved therapies. 'Proactive therapy' is a recent approach in childhood-onset psoriasis that would help to prevent the severity of flare-ups, thus improving the quality of life.
C1 [Dhar, Sandipan] Inst Child Hlth, Dept Pediat Dermatol, Kolkata, West Bengal, India.
   [Srinivas, Sahana] Indira Gandhi Inst Child Hlth, Dept Pediat Dermatol, Bengaluru, Karnataka, India.
   [Dhar, Sandipan] Flat 9C,Palazzo 35,Panditia Rd, Kolkata 700029, West Bengal, India.
RP Dhar, S (corresponding author), Flat 9C,Palazzo 35,Panditia Rd, Kolkata 700029, West Bengal, India.
EM doctorsandipan@gmail.com
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TC 3
Z9 3
U1 1
U2 1
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, Maharashtra, INDIA
SN 0019-5154
EI 1998-3611
J9 INDIAN J DERMATOL
JI Indian J. Dermatol.
PD JUL-AUG
PY 2022
VL 67
IS 4
BP 374
EP 380
DI 10.4103/ijd.ijd_570_22
PG 7
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 6H3BX
UT WOS:000885320800010
PM 36578742
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Bloemer, J
   Pinky, PD
   Govindarajulu, M
   Hong, H
   Judd, R
   Amin, RH
   Moore, T
   Dhanasekaran, M
   Reed, MN
   Suppiramaniam, V
AF Bloemer, Jenna
   Pinky, Priyanka D.
   Govindarajulu, Manoj
   Hong, Hao
   Judd, Robert
   Amin, Rajesh H.
   Moore, Timothy
   Dhanasekaran, Muralikrishnan
   Reed, Miranda N.
   Suppiramaniam, Vishnu
TI Role of Adiponectin in Central Nervous System Disorders
SO NEURAL PLASTICITY
LA English
DT Review
ID ACTIVATED PROTEIN-KINASE; ADIPOSE-SPECIFIC PROTEIN;
   CORONARY-ARTERY-DISEASE; NITRIC-OXIDE PRODUCTION; NECROSIS-FACTOR-ALPHA;
   T-CADHERIN; METABOLIC SYNDROME; CEREBROSPINAL-FLUID; PLASMA ADIPONECTIN;
   SERUM ADIPONECTIN
AB Adiponectin, the most abundant plasma adipokine, plays an important role in the regulation of glucose and lipid metabolism. Adiponectin also possesses insulin-sensitizing, anti-inflammatory, angiogenic, and vasodilatory properties which may influence central nervous system (CNS) disorders. Although initially not thought to cross the blood-brain barrier, adiponectin enters the brain through peripheral circulation. In the brain, adiponectin signaling through its receptors, AdipoR1 and AdipoR2, directly influences important brain functions such as energy homeostasis, hippocampal neurogenesis, and synaptic plasticity. Overall, based on its central and peripheral actions, recent evidence indicates that adiponectin has neuroprotective, antiatherogenic, and antidepressant effects. However, these findings are not without controversy as human observational studies report differing correlations between plasma adiponectin levels and incidence of CNS disorders. Despite these controversies, adiponectin is gaining attention as a potential therapeutic target for diverse CNS disorders, such as stroke, Alzheimer's disease, anxiety, and depression. Evidence regarding the emerging role for adiponectin in these disorders is discussed in the current review.
C1 [Bloemer, Jenna; Pinky, Priyanka D.; Govindarajulu, Manoj; Amin, Rajesh H.; Moore, Timothy; Dhanasekaran, Muralikrishnan; Reed, Miranda N.; Suppiramaniam, Vishnu] Auburn Univ, Dept Drug Discovery & Dev, Auburn, AL 36849 USA.
   [Hong, Hao] China Pharmaceut Univ, Dept Pharmacol, Key Lab Neuropsychiat Dis, Nanjing, Jiangsu, Peoples R China.
   [Judd, Robert] Auburn Univ, Coll Vet Med, Dept Anat Physiol & Pharmacol, Auburn, AL 36849 USA.
   [Amin, Rajesh H.; Moore, Timothy; Dhanasekaran, Muralikrishnan; Reed, Miranda N.; Suppiramaniam, Vishnu] Auburn Univ, Ctr Neurosci, Auburn, AL 36849 USA.
C3 Auburn University System; Auburn University; China Pharmaceutical
   University; Auburn University System; Auburn University; Auburn
   University System; Auburn University
RP Reed, MN; Suppiramaniam, V (corresponding author), Auburn Univ, Dept Drug Discovery & Dev, Auburn, AL 36849 USA.; Reed, MN; Suppiramaniam, V (corresponding author), Auburn Univ, Ctr Neurosci, Auburn, AL 36849 USA.
EM reedmir@auburn.edu; suppivd@auburn.edu
RI Bloemer, Jenna/AAE-3548-2020; Amin, Raj/M-1355-2016; Govindarajulu,
   Manoj/ABB-7883-2021; Pinky, Priyanka/AAN-1430-2021
OI Govindarajulu, Manoj/0000-0003-4739-648X
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NR 132
TC 126
Z9 130
U1 2
U2 21
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2090-5904
EI 1687-5443
J9 NEURAL PLAST
JI Neural. Plast.
PY 2018
VL 2018
AR 4593530
DI 10.1155/2018/4593530
PG 15
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA GQ3QS
UT WOS:000441581900001
PM 30150999
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Albhaisi, S
   Sanyal, AJ
AF Albhaisi, Somaya
   Sanyal, Arun J.
TI Gene-Environmental Interactions as Metabolic Drivers of Nonalcoholic
   Steatohepatitis
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Review
DE NASH; metabolic syndrome; genes; insulin resistance; lipotoxicity;
   oxidative stress; inflammation; gut microbiome
ID FATTY LIVER-DISEASE; FIBROSIS PROGRESSION; SIGNATURE; MECHANISMS;
   PNPLA3; RISK
AB Nonalcoholic fatty liver disease (NAFLD) has emerged as a leading cause of chronic liver disease worldwide in the past few decades as a consequence of the global obesity epidemic and is associated with significant morbidity and mortality. NAFLD is closely associated with components of the metabolic syndrome, type 2 diabetes mellitus and cardiovascular disease, suggesting a plausible metabolic mechanistic basis. Metabolic inflexibility is considered a nidus for NAFLD pathogenesis, causing lipotoxicity, mitochondrial dysfunction and cellular stress leading to inflammation, apoptosis and fibrogenesis, thus mediating disease progression into nonalcoholic steatohepatitis (NASH) and ultimately cirrhosis. In this review, we describe they key metabolic drivers that contribute to development of NAFLD and NASH, and we explain how NASH is a metabolic disease. Understanding the metabolic basis of NASH is crucial for the prevention and treatment of this disease.
C1 [Albhaisi, Somaya] Virginia Commonwealth Univ, Dept Internal Med, Richmond, VA USA.
   [Sanyal, Arun J.] Virginia Commonwealth Univ, Dept Internal Med, Div Gastroenterol Hepatol & Nutr, Richmond, VA 23284 USA.
C3 Virginia Commonwealth University; Virginia Commonwealth University
RP Sanyal, AJ (corresponding author), Virginia Commonwealth Univ, Dept Internal Med, Div Gastroenterol Hepatol & Nutr, Richmond, VA 23284 USA.
EM arun.sanyal@vcuhealth.org
RI Albhaisi, Somaya/S-5392-2017
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NR 132
TC 21
Z9 22
U1 0
U2 6
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD MAY 10
PY 2021
VL 12
AR 665987
DI 10.3389/fendo.2021.665987
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA SG2HK
UT WOS:000653263500001
PM 34040583
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Xu, X
   Lu, LL
   Dong, QY
   Li, XL
   Zhang, NN
   Xin, YN
   Xuan, SY
AF Xu, Xin
   Lu, Linlin
   Dong, Quanyong
   Li, Xiaolin
   Zhang, Nannan
   Xin, Yongning
   Xuan, Shiying
TI Research advances in the relationship between nonalcoholic fatty liver
   disease and atherosclerosis
SO LIPIDS IN HEALTH AND DISEASE
LA English
DT Review
DE Nonalcoholic fatty liver disease; Atherosclerosis; Insulin resistance;
   Metabolic syndrome; Cardiovascular disease
ID CORONARY-ARTERY-DISEASE; OBSTRUCTIVE SLEEP-APNEA; INTIMA-MEDIA
   THICKNESS; NF-KAPPA-B; TYPE-2 DIABETIC-PATIENTS; EPICARDIAL
   ADIPOSE-TISSUE; CHRONIC KIDNEY-DISEASE; INSULIN-RESISTANCE;
   CARDIOVASCULAR-DISEASE; CAROTID ATHEROSCLEROSIS
AB Nonalcoholic fatty liver disease (NAFLD) is a metabolic stress-induced liver disease that is closely related not only to genetic susceptibility but also to insulin resistance and highly linked with metabolic syndrome. In recent years, the prevalence of NAFLD has increased rapidly, paralleling the epidemic of type 2 diabetes mellitus and obesity leading to cardiovascular disease. It has been demonstrated that NAFLD is highly associated with atherosclerosis. With recently gained knowledge, it appears that NAFLD may induce insulin resistance, dyslipidemia, oxidative stress, inflammation, and fluctuation of adipokines associated with atherosclerosis. In this review, we aimed to summarize recent discoveries related to both NAFLD and atherosclerosis, and to identify possible mechanisms linking them.
C1 [Xu, Xin; Dong, Quanyong; Li, Xiaolin; Zhang, Nannan; Xin, Yongning; Xuan, Shiying] Dalian Med Univ, Qingdao Municipal Hosp, Dept Gastroenterol, Qingdao, Peoples R China.
   [Xu, Xin; Lu, Linlin; Dong, Quanyong; Li, Xiaolin; Zhang, Nannan; Xin, Yongning; Xuan, Shiying] Digest Dis Key Lab Qingdao, Qingdao, Peoples R China.
   [Lu, Linlin; Xin, Yongning; Xuan, Shiying] Qingdao Municipal Hosp, Cent Labs, Qingdao, Peoples R China.
C3 Dalian Medical University; Qingdao Municipal Hospital; Qingdao Municipal
   Hospital
RP Xin, YN (corresponding author), Dalian Med Univ, Qingdao Municipal Hosp, Dept Gastroenterol, Qingdao, Peoples R China.
EM xinyongning@163.com; xuansydxy@163.com
RI dong, quanjiang/AAD-3581-2019; Li, Xiaolin/O-5795-2015
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NR 131
TC 44
Z9 48
U1 0
U2 23
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1476-511X
J9 LIPIDS HEALTH DIS
JI Lipids Health Dis.
PD DEC 3
PY 2015
VL 14
AR 158
DI 10.1186/s12944-015-0141-z
PG 8
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA CX6WE
UT WOS:000365841600001
PM 26631018
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Lanaspa, MA
   Tapia, E
   Soto, V
   Sautin, Y
   Sánchez-Lozada, LG
AF Lanaspa, Miguel A.
   Tapia, Edilia
   Soto, Virgilia
   Sautin, Yuri
   Gabriela Sanchez-Lozada, Laura
TI Uric Acid and Fructose: Potential Biological Mechanisms
SO SEMINARS IN NEPHROLOGY
LA English
DT Review
DE Hyperuricemia; fructose; metabolic syndrome; renal damage; oxidative
   stress
ID INDUCED HYPERTENSION; INSULIN-RESISTANCE; NADPH OXIDASE; SOFT DRINKS;
   SUGAR; HYPERURICEMIA; RATS; PATHOGENESIS; ASSOCIATION; CONSUMPTION
AB Excessive fructose consumption is associated with the development of metabolic syndrome and type II diabetes. Both conditions are well-known risk factors for cardiovascular and renal diseases. Uric acid synthesis is linked biochemically to fructose metabolism, thus the widespread consumption of this monosaccharide has been related to steady increasing levels of serum uric acid during the past few decades. Recent evidence has suggested that uric acid may act as a cardiorenal toxin. In this regard, experimental studies have suggested that the primary noxious effect of uric acid occurs inside the cell and is likely the stimulation of oxidative stress. More studies to disclose the harmful mechanisms associated with increasing intracellular uric acid levels after a fructose load are warranted. Semin Nephrol 31:426-432 (C) 2011 Elsevier Inc. All rights reserved.
C1 [Gabriela Sanchez-Lozada, Laura] Inst Nacl Cardiol Ignacio Chavez, Lab Nephrol, Dept Nephrol, Mexico City 14080, DF, Mexico.
   [Lanaspa, Miguel A.] Univ Colorado, Div Renal Dis & Hypertens, Aurora, CO USA.
   [Soto, Virgilia] Hosp Gen Mexico City, Dept Pathol, Mexico City, DF, Mexico.
   [Sautin, Yuri] Univ Florida, Div Nephrol Hypertens & Renal Transplantat, Gainesville, FL USA.
C3 National Institute of Cardiology - Mexico; University of Colorado
   System; University of Colorado Anschutz Medical Campus; Hospital General
   de Mexico; State University System of Florida; University of Florida
RP Sánchez-Lozada, LG (corresponding author), Inst Nacl Cardiol Ignacio Chavez, Lab Nephrol, Dept Nephrol, Res Annex Bldg,4th Floor,Juan Badiano 1, Mexico City 14080, DF, Mexico.
EM lgsanchezlozada@gmail.com
RI Sanchez-Lozada, Laura/AAS-2104-2021; Lanaspa, Miguel/AAO-4971-2020
OI Sanchez-Lozada, Laura-Gabriela/0000-0003-0348-9617; Tapia,
   Edilia/0000-0001-7955-816X
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NR 47
TC 48
Z9 54
U1 2
U2 36
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0270-9295
EI 1558-4488
J9 SEMIN NEPHROL
JI Semin. Nephrol.
PD SEP
PY 2011
VL 31
IS 5
BP 426
EP 432
DI 10.1016/j.semnephrol.2011.08.006
PG 7
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA 841BJ
UT WOS:000296486700006
PM 22000649
DA 2025-06-11
ER

PT J
AU Lu, XY
   Bartfai, T
AF Lu, Xiaoying
   Bartfai, Tamas
TI Analyzing the validity of GalR1 and GalR2 antibodies using knockout mice
SO NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
LA English
DT Article
DE Galanin; Antibody; CNS
ID GALANIN-TRANSGENIC MICE; PHENOTYPIC ANALYSIS; ALZHEIMERS-DISEASE;
   MESSENGER-RNA; RECEPTOR; EXPRESSION; FOREBRAIN; BEHAVIOR; FOCUS
AB G-protein-coupled receptors (GPCRs) comprise the largest family of cell surface receptors and are the major drug targets for the treatment of various human diseases. The lack of sensitive and selective antibodies capable of recognizing endogenous GPCRs, however, hampers the progress of research on this class of receptors. GalR1 through GalR3, GPCRs for the neuropeptide galanin, are potential drug targets for seizure, Alzheimer's disease, depression and anxiety, as well as pain and metabolic syndrome; therefore, determining the cellular and subcellular localization of galanin receptors is of high interest. Several Antibodies raised against galanin receptors are currently available from commercial or academic sources. We have tested several antibodies to GalR1 and GalR2 on tissues from respective knockout mice. Unexpectedly, the immunoreactivity patterns are the same in wild-type and in knockout mice, suggesting that current GalR1 and GalR2 antibodies, under standard immunodetection conditions, might not be suitable for mapping the receptors. These findings argue for taking precaution when using antibodies to galanin receptors.
C1 [Lu, Xiaoying; Bartfai, Tamas] Scripps Res Inst, Harold L Dorris Neurol Res Inst, Mol & Integrat Neurosciences Dept, La Jolla, CA 92037 USA.
C3 Scripps Research Institute
RP Bartfai, T (corresponding author), Scripps Res Inst, Harold L Dorris Neurol Res Inst, Mol & Integrat Neurosciences Dept, SR-307,10550 N Torrey Pines Rd, La Jolla, CA 92037 USA.
EM tbartfai@scripps.edu
RI Lu, Xiao-Ying/I-4171-2014
FU  [MH074055];  [MH063080]
FX We thank Jacinta Lucero (University of California, San Diego) for her
   help in testing various GalR antibodies. We thank Bruno Conti and
   Brendon Ross for reading the manuscript and providing helpful comments.
   The study was supported by MH074055 and MH063080 (T. B).
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NR 19
TC 54
Z9 62
U1 0
U2 7
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0028-1298
J9 N-S ARCH PHARMACOL
JI Naunyn-Schmiedebergs Arch. Pharmacol.
PD APR
PY 2009
VL 379
IS 4
BP 417
EP 420
DI 10.1007/s00210-009-0394-z
PG 4
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 423KF
UT WOS:000264494500013
PM 19159918
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Suliman, HM
   Osman, B
   Abdoon, IH
   Saad, AM
   Khalid, H
AF Suliman, Hayat Mohamed
   Osman, Bashier
   Abdoon, Iman H.
   Saad, Amir Mustafa
   Khalid, Hassan
TI Ameliorative activity of Adansonia digitata fruit on high
   sugar/high fat diet-simulated Metabolic Syndrome model in male Wistar
   rats
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Article
DE Metabolic Syndrome; Oxidative stress; High sugar/high fat diet;
   Antioxidants; Adansonia digitata fruit
ID OXIDATIVE STRESS; LIVER-DISEASE; BAOBAB; DYSFUNCTION; ASSOCIATION;
   DEFINITION; HEPATITIS; EXTRACT; RODENT; HEALTH
AB Metabolic syndrome is a complex of metabolic disorders characterized by oxidative stress which compromises cell functions and entails multiple organs pathologies. We investigated the therapeutic and protective potential of Adansonia digitata fruit -a potent antioxidant- in high sugar/high fat diet-simulated metabolic syndrome in Wistar rats. 42 male rats (140-200 g) were randomly divided into 7 groups. G1 was kept on standard laboratory diet (SLD) for all 9 weeks (negative control). 5 groups were fed high Sugar/high fat diet for 6 weeks then switched to SLD for another 3 weeks+ oral treatment as follows: G2+ no treatment (positive control), G3-G5+ 200, 400 and 800 mg/kg/day aqueous A. digitata fruit respectively, G6 + 10 mg/kg/day Simvastatin. G7 + HS/HFD + 400 mg/kg/day A. digitata fruit simultaneously and was terminated at W6. Our results showed that G2-G6 develops dyslipidemia, hyperglycaemia, weight gain, elevated hepatic biomarkers, elevated creatinine and urea plus pathological derangements in the heart, liver and kidney tissues compared to negative control at W6. 200 mg/kg/day A. digitata fruit significantly ameliorated the induced dyslipidemia (P <= 0.001), hyperglycaemia (P <= 0.001) with a significant reduction in the Atherogenic Index of Plasma (P <= 0.000) after 3 weeks treatment. The fruit normalized the elevated hepatic biomarkers as well as creatinine and urea. A dose dependent partial reduction in lesion intensity was observed in the hepatic tissue while the heart and kidney showed mostly reversed to normal histology. The inflammatory infiltration was eliminated. Relevant results were observed for the two higher doses. The simultaneous treatment showed significant lower levels in all biomarkers investigated compared to positive control which could be interpreted as protective activity. A reduction of 4-11% in whole body weight was achieved.
   Conclusion: MetS was successfully simulated with a HS/HFD formula in male Wistar rats. Treatment with aqueous A. digitata fruit showed anti-Metabolic Syndrome potential reflected by weight loss, anti-inflammatory, hypolipidemic, hypoglycaemic, renal, hepatic and cardio-protective activities.
C1 [Suliman, Hayat Mohamed; Osman, Bashier; Abdoon, Iman H.] Univ Khartoum, Fac Pharm, Dept Pharmacol, 1111 Qasr Ave,POB 1996, Khartoum, Sudan.
   [Saad, Amir Mustafa] Univ Khartoum, Fac Vet Med, Dept Pathol, Khartoum, Sudan.
   [Khalid, Hassan] Univ Khartoum, Fac Pharm, Dept Pharmacognosy, Khartoum, Sudan.
C3 University of Khartoum; University of Khartoum; University of Khartoum
RP Suliman, HM (corresponding author), Univ Khartoum, Fac Pharm, Dept Pharmacol, 1111 Qasr Ave,POB 1996, Khartoum, Sudan.
EM hayatibrahimsuliman19@gmail.com
RI Abdoon, Iman/E-5919-2019; Osman, Bashier/AAW-2543-2021
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NR 91
TC 13
Z9 15
U1 1
U2 17
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD MAY
PY 2020
VL 125
AR 109968
DI 10.1016/j.biopha.2020.109968
PG 11
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA KU2DX
UT WOS:000519520000020
PM 32066041
OA gold
DA 2025-06-11
ER

PT J
AU Appannah, G
   Emi, NA
   Gan, WY
   Shariff, ZM
   Shamsuddin, NH
   Zaini, AA
   Appukutty, M
AF Appannah, Geeta
   Emi, Nor Aishah
   Gan, Wan Ying
   Shariff, Zalilah Mohd
   Shamsuddin, Nurainul Hana
   Zaini, Azriyanti Anuar
   Appukutty, Mahenderan
TI The Relationships between a Dietary Pattern Linked to Cardiometabolic
   Risk Factors and Life Satisfaction in Early Adolescence
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Article
DE dietary patterns; life satisfaction; adolescents; Malaysia
ID MENTAL-HEALTH; NEUROTROPHIC FACTOR; DEPRESSION; CHILDHOOD; ASSOCIATIONS;
   INFLAMMATION; DISORDERS; OUTCOMES; QUALITY; FAT
AB Little is known about the contribution of dietary patterns of poor quality on life satisfaction among Malaysian children. We evaluated associations between an empirically derived "high sugar, high fibre, high dietary energy dense (DED) and low fat" dietary pattern and life satisfaction score in adolescents. A total of 548 adolescents aged 13 years were recruited from randomly selected public schools located in three southern states of Peninsular Malaysia. Dietary intake was assessed using a validated food frequency questionnaire (FFQ) while life satisfaction was measured using a Multidimensional Students' Life Satisfaction Scale (MSLSS). Z-score for a "high sugar, high fibre, high DED and low fat" dietary pattern was estimated by applying reduced rank regression analysis. Relationships between the dietary pattern and life satisfaction scores were assessed using regression models. Mean and SD of life satisfaction score was higher in girls (70.5 (12.8)) compared to boys (67.6 (15.4)),p< 0.05. The overall life satisfaction score (beta= -0.119; 95% CI: -0.125, -0.004) was inversely associated with dietary pattern z-score as well as scores for self (beta= -0.13; 95% CI: -0.170, -0.015) and living environment (beta= -0.12; 95% CI: -0.163, -0.007) domains in girls. An opposite trend was observed for school domain in boys whereby an increasing dietary pattern score was positively associated with increasing life satisfaction score (beta= 0.216; 95% CI: 0.054, 0.36). The finding of this study highlights the role of free sugar and DED particularly, within the framework of whole diet, and target population at risk to improve life satisfaction among adolescents.
C1 [Appannah, Geeta; Emi, Nor Aishah; Gan, Wan Ying; Shariff, Zalilah Mohd] Univ Putra Malaysia, Fac Med & Hlth Sci, Dept Nutr & Dietet, Serdang 43400, Selangor, Malaysia.
   [Shamsuddin, Nurainul Hana] Univ Putra Malaysia, Fac Med & Hlth Sci, Dept Family Med, Serdang 43400, Selangor, Malaysia.
   [Zaini, Azriyanti Anuar] Univ Malaya, Fac Med, Dept Paediat, Kuala Lumpur 50603, Malaysia.
   [Appukutty, Mahenderan] Univ Teknol MARA, Fac Sports Sci & Recreat, Sports Sci Programme, Shah Alam 40450, Selangor, Malaysia.
C3 Universiti Putra Malaysia; Universiti Putra Malaysia; Universiti Malaya;
   Universiti Teknologi MARA
RP Appannah, G (corresponding author), Univ Putra Malaysia, Fac Med & Hlth Sci, Dept Nutr & Dietet, Serdang 43400, Selangor, Malaysia.
EM geeta@upm.edu.my; aishahemi292@gmail.com; wanying@upm.edu.my;
   zalilahms@upm.edu.my; nurainul@upm.edu.my; azriyanti@ummc.edu.my;
   mahen@uitm.edu.my
RI Anuar Zaini, Azriyanti/F-8885-2010; MEDIC, NURAINUL/AAY-6897-2021;
   Appukutty, Mahenderan/AAF-2745-2020; Appannah, Geeta/L-7650-2017; Gan,
   Wan Ying/N-2445-2019
OI Appannah, Geeta/0000-0003-4636-6529; Appukutty,
   Mahenderan/0000-0001-8114-5575; Shamsuddin, Nurainul
   Hana/0000-0001-8326-0024; Mohd Shariff, Zalilah/0000-0002-5347-4627;
   Gan, Wan Ying/0000-0002-9016-3414
FU Ministry of Education Malaysia [FRGS/2/2014/SKK10/UPM/02/10]
FX This work was supported by a research grant from the Ministry of
   Education Malaysia (FRGS/2/2014/SKK10/UPM/02/10). The funder had no role
   in the design of the study; in the collection, analyses, or
   interpretation of data; in the writing of the manuscript, or in the
   decision to publish the results.
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NR 42
TC 5
Z9 5
U1 0
U2 4
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD AUG
PY 2020
VL 17
IS 15
AR 5489
DI 10.3390/ijerph17155489
PG 12
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA NA0HF
UT WOS:000559500600001
PM 32751389
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Kapniari, E
   Papadimitriou, P
   Dalamaga, M
   Makavos, G
   Piaserico, S
   Egeberg, A
   Ikonomidis, I
   Papadavid, E
AF Kapniari, Eirini
   Papadimitriou, Prokopios
   Dalamaga, Marianna
   Makavos, George
   Piaserico, Stefano
   Egeberg, Alexander
   Ikonomidis, Ignatios
   Papadavid, Evangelia
TI Investigating the Link between Psoriasis and Cardiovascular Disease:
   Current Evidence, Therapeutic Implications and Perspectives
SO CURRENT VASCULAR PHARMACOLOGY
LA English
DT Review
DE Psoriasis; cardiovascular diseases; inflammation; anti-inflammatory
   agents; biologics; skin disease
ID NECROSIS-FACTOR-ALPHA; CHRONIC PLAQUE PSORIASIS;
   POSITRON-EMISSION-TOMOGRAPHY; CORONARY-ARTERY-DISEASE; INDEPENDENT
   RISK-FACTOR; POPULATION-BASED COHORT; INTIMA-MEDIA THICKNESS;
   ANTI-TNF-THERAPY; QUALITY-OF-LIFE; RHEUMATOID-ARTHRITIS
AB Psoriasis; a chronic inflammatory disease is characterized by symmetric hyperkeratotic plaques affecting any part of the body. Psoriasis is nowadays considered as a systemic inflammation linked with several comorbidities as metabolic syndrome, depression, anxiety and increased prevalence of cardiovascular (CV) disease. The hypothesis that psoriasis is an independent CV risk factor leading to atherosclerosis via inflammation is now widely accepted. Deciphering the underlying mechanisms interconnecting psoriasis and CV disease may have significant implications in treatment decisions. Accumulating evidence suggests that systematic therapies and recently introduced biologic agents, that control psoriasis by suppressing the chronic and systemic inflammation, may alter the progression of CV disease. We herein attempt a review of current evidence analysing the relationship between psoriasis and CV comorbidities, comment on the mechanisms underlying this association and investigate the consequences for the management of psoriasis.
C1 [Kapniari, Eirini; Papadavid, Evangelia] Natl & Kapodistrian Univ Athens, Attikon Hosp, Dept Dermatol & Venereol 2, Med Sch, Athens, Greece.
   [Papadimitriou, Prokopios] Hull Univ Teaching Hosp, Dept Cardiol, NHS Hull, Kingston Upon Hull, N Humberside, England.
   [Dalamaga, Marianna] Natl & Kapodistrian Univ Athens, Med Sch, Dept Biol Chem, Athens, Greece.
   [Makavos, George; Ikonomidis, Ignatios] Natl & Kapodistrian Univ Athens, Attikon Hosp, Dept Cardiol 2, Med Sch, Athens, Greece.
   [Piaserico, Stefano] Univ Padua, Dept Dermatol, Padua, Italy.
   [Egeberg, Alexander] Univ Copenhagen, Herlev & Gentofte Hosp, Dept Dermatol, Hellerup, Denmark.
   [Egeberg, Alexander] Univ Copenhagen, Herlev & Gentofte Hosp, Dept Allergy, Hellerup, Denmark.
C3 National & Kapodistrian University of Athens; University Hospital
   Attikon; National & Kapodistrian University of Athens; University
   Hospital Attikon; National & Kapodistrian University of Athens;
   University of Padua; University of Copenhagen; University of Copenhagen
RP Kapniari, E (corresponding author), Natl & Kapodistrian Univ Athens, Dept Dermatologist & Venereologist 2, Med Sch, Attikon Hosp, Athens 12462, Greece.
EM kapniari_27@yahoo.gr
RI Papadavid, Evangelia/A-9211-2015; Dalamaga, Maria/A-4041-2013; Egeberg,
   Alexander/AFO-3479-2022
OI Kapniari, Eirini/0000-0001-5769-040X; piaserico,
   stefano/0000-0002-1091-4733; Dalamaga, Maria/0000-0002-7008-388X
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NR 188
TC 6
Z9 6
U1 1
U2 6
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1570-1611
EI 1875-6212
J9 CURR VASC PHARMACOL
JI Current Vascular Pharmacology
PY 2020
VL 18
IS 6
BP 592
EP 609
DI 10.2174/1570161118666200523154318
PG 18
WC Pharmacology & Pharmacy; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Cardiovascular System & Cardiology
GA NR3TC
UT WOS:000571485100006
PM 32445456
DA 2025-06-11
ER

PT J
AU Mohn, A
   Chiavaroli, V
   Cerruto, M
   Blasetti, A
   Giannini, C
   Bucciarelli, T
   Chiarelli, F
AF Mohn, Angelika
   Chiavaroli, Valentina
   Cerruto, Marina
   Blasetti, Annalisa
   Giannini, Cosimo
   Bucciarelli, Tonino
   Chiarelli, Francesco
TI Increased oxidative stress in prepubertal children born small for
   gestational age
SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Article
ID CATCH-UP GROWTH; CORONARY-HEART-DISEASE; INSULIN-RESISTANCE SYNDROME;
   REDUCED FETAL-GROWTH; METABOLIC SYNDROME; BIRTH-WEIGHT;
   GLUCOSE-TOLERANCE; CHILDHOOD GROWTH; INFANT GROWTH; ADULT LIFE
AB Context: Low birth weight is associated with an increased risk of metabolic and cardiovascular diseases in adulthood. The development of insulin resistance (IR) seems to play a pivotal role; no data on the oxidant-antioxidant status are available in this risk group.
   Objective: This study is an assessment of oxidant-antioxidant status in prepubertal children born small for gestational age (SGA) in comparison to healthy controls and the relationship to IR.
   Design: This cross-sectional study compares indexes of IR and oxidant-antioxidant status in three different groups (SGA+, SGA-, controls), with analysis by post hoc and Pearson correlation.
   Setting: The study was conducted in the Academic Department of Pediatrics.
   Participants: A total of 19 SGA+ and 16 SGA- children were compared with 13 controls.
   Intervention: No intervention was used.
   Main Outcome Measures: Indexes of IR (glucose to insulin ratio, homeostasis model assessment of IR) were evaluated, and markers of oxidative stress (lag phase, malonildialdehyde, vitamin E) were measured.
   Results: Homeostasis model assessment of IR was significantly higher in SGA+ than SGA- children (1.32 +/- 0.9 vs. 0.69 +/- 0.47; P = 0.03) and controls (0.71 +/- 0.37; P = 0.04). Glucose to insulin ratio was significantly lower in SGA+ than SGA- children (12.41 +/- 5.01 vs. 26.54 +/- 17.18; P = 0.02) and controls (26.96 +/- 20.70; P = 0.04). Lag phase was significantly shorter in SGA+ than SGA- children (24.3 +/- 4.38 vs. 35.59 +/- 11.29 min; P = 0.003) and controls (45.28 +/- 7.69 min; P = 0.0001) and in SGA- than controls ( P = 0.01). Malonildialdehyde was significantly higher in SGA+ than SGA- children (0.79 +/- 0.3 vs. 0.6 +/- 0.1 nmol/mg; P = 0.03) and controls (0.36 +/- 0.04 nmol/mg; P = 0.0001) and in SGA- children than controls ( P = 0.02). Vitamin E was significantly reduced in SGA- children than controls (27.54 +/- 7.9 vs. 43.23 +/- 11.32 mu mol/liter; P = 0.002).
   Conclusion: Oxidative stress is present in both SGA+ and SGA- children, with a continuous alteration in relation to IR. Therefore, catch-up growth might exert the greatest influence in the development of future diseases.
C1 Univ G dAnnunzio, Dept Pediat, I-66100 Chieti, Italy.
   Univ G dAnnunzio, Dept Biochem, I-66100 Chieti, Italy.
C3 G d'Annunzio University of Chieti-Pescara; G d'Annunzio University of
   Chieti-Pescara
RP Mohn, A (corresponding author), Univ G dAnnunzio, Dept Pediat, Via Dei Vestini 15, I-66100 Chieti, Italy.
EM amohn@unich.it
RI Chiavaroli, Valentina/ABB-1911-2020; Giannini, Cosimo/K-9631-2016
OI Giannini, Cosimo/0000-0002-2904-2744; BUCCIARELLI,
   Tonino/0000-0002-5001-0165; Chiavaroli, Valentina/0000-0003-0555-2173
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NR 56
TC 49
Z9 53
U1 0
U2 1
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0021-972X
EI 1945-7197
J9 J CLIN ENDOCR METAB
JI J. Clin. Endocrinol. Metab.
PD APR
PY 2007
VL 92
IS 4
BP 1372
EP 1378
DI 10.1210/jc.2006-1344
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 153WH
UT WOS:000245466600031
PM 17264184
DA 2025-06-11
ER

PT J
AU Eskenazi, B
   Gunier, RB
   Rauch, S
   Kogut, K
   Perito, ER
   Mendez, X
   Limbach, C
   Holland, N
   Bradman, A
   Harley, KG
   Mills, PJ
   Mora, AM
AF Eskenazi, Brenda
   Gunier, Robert B.
   Rauch, Stephen
   Kogut, Katherine
   Perito, Emily R.
   Mendez, Xenia
   Limbach, Charles
   Holland, Nina
   Bradman, Asa
   Harley, Kim G.
   Mills, Paul J.
   Mora, Ana M.
TI Association of Lifetime Exposure to Glyphosate and Aminomethylphosphonic
   Acid (AMPA) with Liver Inflammation and Metabolic Syndrome at Young
   Adulthood: Findings from the CHAMACOS Study
SO ENVIRONMENTAL HEALTH PERSPECTIVES
LA English
DT Article
ID OXIDATIVE STRESS; HERBICIDES; CHILDREN; ROUNDUP; CHROMATOGRAPHY; WATER;
   US; DIFFERENTIATION; QUESTIONNAIRE; GENOTOXICITY
AB BACKGROUND: The prevalence of liver disorders and metabolic syndrome has increased among youth. Glyphosate, the most widely used herbicide worldwide, could contribute to the development of these conditions.OBJECTIVE: We aimed to assess whether lifetime exposure to glyphosate and its degradation product, aminomethylphosphonic acid (AMPA), is asso-ciated with elevated liver transaminases and metabolic syndrome among young adults.METHODS: We conducted a prospective cohort study (n = 480 mother-child dyads) and a nested case-control study (n = 60 cases with elevated liver transaminases and 91 controls) using data from the Center for the Health Assessment of Mothers and Children of Salinas (CHAMACOS). We meas-ured glyphosate and AMPA concentrations in urine samples collected during pregnancy and at child ages 5, 14, and 18 y from cases and controls. We calculated glyphosate residue concentrations: [glyphosate + o1.5 x AMPA thorn ]. We estimated the amount of agricultural-use glyphosate applied within a 1-km radius of every residence from pregnancy to age 5 y for the full cohort using California Pesticide Use Reporting data. We assessed liver transa-minases and metabolic syndrome at 18 y of age.RESULTS: Urinary AMPA at age 5 y was associated with elevated transaminases [relative risk (RR) per 2-fold increase =1.27, 95% confidence interval (CI): 1.06, 1.53] and metabolic syndrome (RR = 2.07, 95% CI: 1.38, 3.11). Urinary AMPA and glyphosate residues at age 14 y were associated with metabolic syndrome [RR = 1.80 (95% CI: 1.10, 2.93) and RR = 1.88 (95% CI: 1.03, 3.42), respectively]. Overall, a 2-fold increase in urinary AMPA during childhood was associated with a 14% and a 55% increased risk of elevated liver transaminases and metabolic syndrome, respectively. Living near agricultural glyphosate applications during early childhood (birth to 5 y of age) was also associated with metabolic syndrome at age 18 y in the case-control group (RR = 1.53, 95% CI: 1.16, 2.02).DISCUSSION: Childhood exposure to glyphosate and AMPA may increase risk of liver and cardiometabolic disorders in early adulthood, which could lead to more serious diseases later in life. https://doi.org/10.1289/EHP11721
C1 [Eskenazi, Brenda; Gunier, Robert B.; Rauch, Stephen; Kogut, Katherine; Mendez, Xenia; Holland, Nina; Bradman, Asa; Harley, Kim G.; Mora, Ana M.] Univ Calif Berkeley, Ctr Environm Res & Community Hlth CERCH, Sch Publ Hlth, Berkeley, CA USA.
   [Perito, Emily R.] Univ Calif San Francisco, Dept Pediat, San Francisco, CA USA.
   [Perito, Emily R.] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA USA.
   [Limbach, Charles] Monterey Cty Hlth Dept, Salinas, CA USA.
   [Bradman, Asa] Univ Calif Merced, Dept Publ Hlth, Merced, CA USA.
   [Mills, Paul J.] Univ Calif San Diego, Dept Family Med & Publ Hlth, La Jolla, CA USA.
   [Eskenazi, Brenda] Univ Calif Berkeley, Ctr Environm Res & Community Hlth CERCH, Sch Publ Hlth, 1995 Univ Ave,Suite 265, Berkeley, CA 94704 USA.
C3 University of California System; University of California Berkeley;
   University of California System; University of California San Francisco;
   University of California System; University of California San Francisco;
   University of California System; University of California Merced;
   University of California System; University of California San Diego;
   University of California System; University of California Berkeley
RP Eskenazi, B (corresponding author), Univ Calif Berkeley, Ctr Environm Res & Community Hlth CERCH, Sch Publ Hlth, 1995 Univ Ave,Suite 265, Berkeley, CA 94704 USA.
EM eskenazi@berkeley.edu
RI Harley, Kim/NDT-0453-2025
OI Mora, Ana Maria/0000-0002-2008-9714
FU National Institute of Environmental Health Sciences (NIEHS) [UH3
   ES030631, R24 ES028529, R01 ES026994, P01 ES009605, R01 ES017054, R01
   ES021369]; National Institutes of Health (NIH) [R01 DA035300]; National
   Institute on Drug Abuse (NIDA); U.S. EPA [R82670901, RD83171001,
   RD83451301]; New York Community Trust; Westreich Foundation
FX The authors thank the Salinas research team for their dedicated work
   collecting these data and the UC Berkeley biorepository team for
   preserving and managing biological samples. The authors also thank the
   CHAMACOS families for their years of participation.This work was
   funded by research grant numbers UH3 ES030631, R24 ES028529, R01
   ES026994, P01 ES009605, R01 ES017054, and R01 ES021369 from the National
   Institute of Environmental Health Sciences (NIEHS), National Institutes
   of Health (NIH); R01 DA035300 from the National Institute on Drug Abuse
   (NIDA, NIH) ; and R82670901, RD83171001, and RD83451301 from the U.S.
   EPA. Additional support for this study was provided by The Solomon Dutka
   Fund in the New York Community Trust and The Westreich Foundation.
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NR 93
TC 35
Z9 36
U1 3
U2 16
PU US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE
PI RES TRIANGLE PK
PA NATL INST HEALTH, NATL INST ENVIRONMENTAL HEALTH SCIENCES, PO BOX 12233,
   RES TRIANGLE PK, NC 27709-2233 USA
SN 0091-6765
EI 1552-9924
J9 ENVIRON HEALTH PERSP
JI Environ. Health Perspect.
PD MAR
PY 2023
VL 131
IS 3
AR 037001
DI 10.1289/EHP11721
PG 11
WC Environmental Sciences; Public, Environmental & Occupational Health;
   Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health; Toxicology
GA H0CG7
UT WOS:000992724400010
PM 36856429
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Pishgahi, A
   Abolhasan, R
   Danaii, S
   Amanifar, B
   Soltani-Zangbar, MS
   Zamani, M
   Kamrani, A
   Ghorbani, F
   Mehdizadeh, A
   Kafil, HS
   Jadidi-Niaragh, F
   Yousefi, B
   Hajialiloo, M
   Yousefi, M
AF Pishgahi, Alireza
   Abolhasan, Rozita
   Danaii, Shahla
   Amanifar, Bahareh
   Soltani-Zangbar, Mohammad Sadegh
   Zamani, Majid
   Kamrani, Amin
   Ghorbani, Farzaneh
   Mehdizadeh, Amir
   Kafil, Hossein Samadi
   Jadidi-Niaragh, Farhad
   Yousefi, Bahman
   Hajialiloo, Mehrzad
   Yousefi, Mehdi
TI Immunological and oxidative stress biomarkers in Ankylosing Spondylitis
   patients with or without metabolic syndrome
SO CYTOKINE
LA English
DT Article
DE Ankylosing Spondylitis; Immunological factors; Metabolic syndrome;
   Oxidative stress
ID NECROSIS-FACTOR-ALPHA; REGULATORY T-CELLS; TNF-ALPHA; MONONUCLEAR-CELLS;
   PERIPHERAL-BLOOD; HIGH PREVALENCE; KAPPA-B; ADIPONECTIN; EXPRESSION;
   SERUM
AB Ankylosing Spondylitis (AS) is a chronic inflammatory disorder of the spine and sacroiliac joints with unidentified etiology closely associated with metabolic syndrome (MetS). Recent studies have reported that immunological and oxidative stress factors are implicated in AS pathogenesis. The aim of this study was to investigate the oxidative and immunological factors in AS patients with or without MetS compare to control group. Real-Time PCR measured expression level of cytokines, transcription factors and related miRNAs. In addition, Th17 and Treg frequencies and cytokines secretion were evaluated by flowcytometry and ELISA methods, respectively. The oxidative stress biomarkers were also assessed with biochemical methods. In AS patients with MetS, higher Th17 and lower Treg frequency were observed. Increased levels of NF-kB and AP-1 mRNA expression were seen in AS patients with MetS (p = 0.0263 and p = 0.0104, respectively). MiR-146a and miR-223 were significantly decreased (p = 0.0005, p = 0.0161, respectively) and increase in miR-21 (p = 0.0002) was observed in AS patients with MetS compared to AS patients without MetS. Additionally, the secretion of TNF-a (p = 0.0167), IL-1 beta (p = 0.303), CCL2 (p = 0.0254), CCL3 (p = 0.0119), CXCL8 (p = 0.0364), adiponectin (p = 0.0183) and the levels of SOD (p = 0.0421), NO (p = 0.0451) and CAT (p = 0.0128) were increased in AS patients with MetS. We were not observed significant differences in TOS and GPX levels between studied groups. The higher levels of oxidative stress and immunological inflammatory markers in AS patients with MetS provide further evidences on the oxidative stress and immunological relationship in these patients.
C1 [Pishgahi, Alireza] Tabriz Univ Med Sci, Phys Med & Rehabil Res Ctr, Tabriz, Iran.
   [Abolhasan, Rozita; Amanifar, Bahareh; Hajialiloo, Mehrzad; Yousefi, Mehdi] Tabriz Univ Med Sci, Connect Tissue Dis Res Ctr, Tabriz, Iran.
   [Danaii, Shahla] Eastern Azerbaijan ACECR Art Ctr, Gynecol Dept, Eastern Azerbaijan Branch ACECR, Tabriz, Iran.
   [Soltani-Zangbar, Mohammad Sadegh] Tabriz Univ Med Sci, Student Res Comm, Tabriz, Iran.
   [Soltani-Zangbar, Mohammad Sadegh; Zamani, Majid; Kamrani, Amin; Yousefi, Mehdi] Tabriz Univ Med Sci, Stem Cell Res Ctr, Tabriz, Iran.
   [Ghorbani, Farzaneh; Jadidi-Niaragh, Farhad] Tabriz Univ Med Sci, Fac Med, Dept Immunol, Tabriz, Iran.
   [Mehdizadeh, Amir] Tabriz Univ Med Sci, Endocrine Res Ctr, Tabriz, Iran.
   [Mehdizadeh, Amir] Tabriz Univ Med Sci, Comprehens Hlth Lab, Tabriz, Iran.
   [Kafil, Hossein Samadi; Yousefi, Bahman] Tabriz Univ Med Sci, Drug Appl Res Ctr, Tabriz, Iran.
   [Yousefi, Mehdi] Tabriz Univ Med Sci, Aging Res Inst, Tabriz, Iran.
C3 Tabriz University of Medical Science; Tabriz University of Medical
   Science; Tabriz University of Medical Science; Tabriz University of
   Medical Science; Tabriz University of Medical Science; Tabriz University
   of Medical Science; Tabriz University of Medical Science; Tabriz
   University of Medical Science; Tabriz University of Medical Science
RP Yousefi, M (corresponding author), Tabriz Univ Med Sci, Fac Med, Dept Immunol, Tabriz, Iran.
EM yousefime@tbzmed.ac.ir
RI Zamani, Majid/AAP-3653-2020; yousefi, mehdi/HHZ-3147-2022; yousefi,
   Bahman/AAI-2969-2021; Samadi Kafil, Hossein/AAX-2888-2021; Pishgahi,
   Alireza/L-8414-2017; Soltani-Zangbar, Mohammad Sadegh/AAC-2625-2022;
   Jadidi-Niaragh, Farhad/D-3985-2017; Samadi Kafil, Hossein/B-5855-2012
OI Yousefi, Mehdi/0000-0003-0099-6728; Samadi Kafil,
   Hossein/0000-0001-6026-8795; Danaii, Shahla/0000-0002-2800-1975; Zamani,
   Majid/0000-0002-7260-2348; Soltani-Zangbar, Mohammad
   Sadegh/0000-0003-3960-5712
FU Tabriz University of Medical Sciences, Tabriz, Iran [59657]
FX This study was supported by Tabriz University of Medical Sciences,
   Tabriz, Iran (Grant No. 59657).
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NR 71
TC 31
Z9 34
U1 0
U2 2
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 1043-4666
EI 1096-0023
J9 CYTOKINE
JI Cytokine
PD APR
PY 2020
VL 128
AR 155002
DI 10.1016/j.cyto.2020.155002
PG 10
WC Biochemistry & Molecular Biology; Cell Biology; Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology; Immunology
GA KS7MT
UT WOS:000518491500006
PM 31986444
DA 2025-06-11
ER

PT J
AU Arshad, NA
   Lin, TS
   Yahaya, MF
AF Arshad, Nurul Ain
   Lin, Teoh Seong
   Yahaya, Mohamad Fairuz
TI Metabolic Syndrome and Its Effect on the Brain: Possible Mechanism
SO CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
LA English
DT Review
DE Metabolic syndrome; brain effect; possible pathology; insulin
   resistance; International Diabetic Federation (IDF); diagnosis
ID ALZHEIMERS-DISEASE BRAIN; TYPE-2 DIABETES-MELLITUS; OBESE ZUCKER RATS;
   OXIDATIVE STRESS; INSULIN-RESISTANCE; COGNITIVE IMPAIRMENT;
   NITRIC-OXIDE; MITOCHONDRIAL DYSFUNCTION; ENDOTHELIAL DYSFUNCTION;
   SYNAPTIC PLASTICITY
AB Background & Objective: Metabolic syndrome (MetS) is an interconnected group of physiological, biochemical, clinical and metabolic factors that directly increase the risk of cardiovascular disease, type 2 diabetes mellitus (T2DM) and mortality. Rising evidence suggests that MetS plays a significant role in the progression of Alzheimer's disease and other neurodegenerative diseases. Nonetheless, the factors linking this association has not yet been elucidated. As we are facing an increasing incidence of obesity and T2DM in all stages of life, understanding the association of MetS and neurodegenerative diseases is crucial to lessen the burden of the disease.
   Conclusion: In this review, we will discuss the possible mechanisms which may relate the association between MetS and cognitive decline which include vascular damages, elevation of reactive oxygen species (ROS), insulin resistance and low-grade inflammation.
C1 [Arshad, Nurul Ain; Lin, Teoh Seong; Yahaya, Mohamad Fairuz] Univ Kebangsaan Malaysia, Med Ctr, Dept Anat, Kuala Lumpur 56000, Malaysia.
C3 Universiti Kebangsaan Malaysia
RP Yahaya, MF (corresponding author), Univ Kebangsaan Malaysia, Med Ctr, Dept Anat, Fac Med, Jalan Yaacob Latif, Kuala Lumpur 56000, Malaysia.
EM mfairuzy@ukm.edu.my
RI Teoh, Seong/P-3950-2017; Yahaya, Mohamad/K-7614-2019
OI Arshad, Nurul 'Ain/0000-0002-9761-7941
FU Faculty of Medicine, Universiti Kebangsaan Malaysia [FF-2017-449]
FX This article is supported by the Faculty of Medicine, Universiti
   Kebangsaan Malaysia Grant FF-2017-449.
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NR 120
TC 47
Z9 49
U1 1
U2 7
PU BENTHAM SCIENCE PUBL
PI BUSUM
PA PO BOX 294, BUSUM, 1400 AG, NETHERLANDS
SN 1871-5273
EI 1996-3181
J9 CNS NEUROL DISORD-DR
JI CNS Neurol. Disord.-Drug Targets
PY 2018
VL 17
IS 8
BP 595
EP 603
DI 10.2174/1871527317666180724143258
PG 9
WC Neurosciences; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pharmacology & Pharmacy
GA GX5TM
UT WOS:000447813600003
PM 30047340
DA 2025-06-11
ER

PT J
AU Francisco, FA
   Saavedra, LPJ
   Junior, MDF
   Barra, C
   Matafome, P
   Mathias, PCF
   Gomes, RM
AF Francisco, Flavio A.
   Saavedra, Lucas P. J.
   Junior, Marcos D. F.
   Barra, Catia
   Matafome, Paulo
   Mathias, Paulo C. F.
   Gomes, Rodrigo M.
TI Early AGEing and metabolic diseases: is perinatal exposure to
   glycotoxins programming for adult-life metabolic syndrome?
SO NUTRITION REVIEWS
LA English
DT Review
DE advanced glycation end products (AGEs); glycotoxins; metabolic
   programming; metabolic syndrome; methylglyoxal
ID GLYCATION END-PRODUCTS; METHYLGLYOXAL INDUCES APOPTOSIS;
   N-EPSILON-CARBOXYMETHYLLYSINE; MAILLARD REACTION-PRODUCTS; ENDOTHELIAL
   GROWTH-FACTOR; LENS EPITHELIAL-CELLS; RED-BLOOD-CELLS; OXIDATIVE STRESS;
   IN-VITRO; GLYOXALASE SYSTEM
AB Perinatal early nutritional disorders are critical for the developmental origins of health and disease. Glycotoxins, or advanced glycation end-products, and their precursors such as the methylglyoxal, which are formed endogenously and commonly found in processed foods and infant formulas, may be associated with acute and long-term metabolic disorders. Besides general aspects of glycotoxins, such as their endogenous production, exogenous sources, and their role in the development of metabolic syndrome, we discuss in this review the sources of perinatal exposure to glycotoxins and their involvement in metabolic programming mechanisms. The role of perinatal glycotoxin exposure in the onset of insulin resistance, central nervous system development, cardiovascular diseases, and early aging also are discussed, as are possible interventions that may prevent or reduce such effects.
C1 [Francisco, Flavio A.; Saavedra, Lucas P. J.; Mathias, Paulo C. F.] Univ Estadual Maringa, Dept Biotechnol Genet & Cellular Biol, Maringa, Parana, Brazil.
   [Junior, Marcos D. F.; Gomes, Rodrigo M.] Univ Fed Goias, Dept Physiol Sci, Goiania, Go, Brazil.
   [Barra, Catia; Matafome, Paulo] Univ Coimbra, Fac Med, Inst Physiol, Coimbra, Portugal.
   [Barra, Catia; Matafome, Paulo] Univ Coimbra, Fac Med, Coimbra Inst Clin & Biomed Res, Coimbra, Portugal.
   [Barra, Catia; Matafome, Paulo] Univ Coimbra, Ctr Innovat Biotechnol & Biomed, Coimbra, Portugal.
   [Barra, Catia; Matafome, Paulo] Clin Acad Ctr Coimbra, Coimbra, Portugal.
C3 Universidade Estadual de Maringa; Universidade Federal de Goias;
   Universidade de Coimbra; Universidade de Coimbra; Universidade de
   Coimbra; Universidade de Coimbra
RP Gomes, RM (corresponding author), Univ Fed Goias, Biol Sci Inst, Dept Physiol Sci, 2,Room 101,Esperanca Ave S-N, BR-74690900 Goiania, Go, Brazil.
EM Gomesrm@ufg.br
RI Saavedra, Lucas/AAX-5983-2020; Ferreira-Junior, Marcos
   Divino/IXD-8953-2023; DE FREITAS MATHIAS, PAULO/AAQ-9682-2021; Matafome,
   Paulo/AAQ-4113-2020; Mello Gomes, Rodrigo/L-2639-2016
OI Jacinto Saavedra, Lucas Paulo/0000-0003-0825-426X; Mello Gomes,
   Rodrigo/0000-0002-9012-3287; de Freitas Mathias, Paulo
   Cezar/0000-0001-6994-4585; Matafome, Paulo/0000-0002-3422-290X;
   Ferreira-Junior, Marcos Divino/0000-0003-0490-1212
FU Conselho Nacional de Desenvolvimento Cientifico e Tecnologico;
   Coordenacao de Aperfeicoamento Pessoal de Nivel Superior
FX Financial support was received from the following Brazilian funding
   agencies: Conselho Nacional de Desenvolvimento Cientifico e Tecnologico
   and Coordenacao de Aperfeicoamento Pessoal de Nivel Superior. None of
   the funding agencies were involved with the conception, design,
   performance, or approval of this study.
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NR 218
TC 5
Z9 5
U1 1
U2 16
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0029-6643
EI 1753-4887
J9 NUTR REV
JI Nutr. Rev.
PD JAN
PY 2021
VL 79
IS 1
BP 13
EP 24
DI 10.1093/nutrit/nuaa074
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nutrition & Dietetics
GA PR1IE
UT WOS:000606995100002
PM 32951053
OA Bronze
DA 2025-06-11
ER

PT J
AU Dahlquist, KJV
   Voth, LC
   Fee, AJ
   Stoeckman, AK
AF Dahlquist, Korbyn J., V
   Voth, Laura C.
   Fee, Amanda J.
   Stoeckman, Angela K.
TI An Autocrine Role for CXCL1 in Progression of Hepatocellular Carcinoma
SO ANTICANCER RESEARCH
LA English
DT Article
DE Hepatocellular carcinoma; CXCL1; CXCR2; palmitate
ID INSULIN-RESISTANCE; FATTY; HEPATOCYTES; METABOLISM; CELLS; OBESITY;
   MODELS
AB Background: One of the most prevalent causes of cancer fatalities is hepatocellular carcinoma (HCC), which has been linked to metabolic syndrome. Circulating levels of the saturated fatty acid palmitate are elevated in metabolic syndrome and lead to cellular stress. Materials and Methods: Using enzyme-linked immunosorbent assay, flow cytometry, and migration assays, we characterized the response of rat hepatoma cells to palmitate treatment. Results: We detected a 60% increase in secretion of C-X-C motif ligand 1 (CXCL1) which was dose-dependent and coincided with apoptosis. We measured expression of C-X-C motif chemokine receptor 2 (CXCR2) and observed a 4.5-fold increase on apoptotic hepatoma cells. Furthermore, we assayed migration of hepatoma cells and saw a 2-fold increase in the number of migrating cells towards CXCL1. Conclusion: These findings suggest that HCC cells secrete CXCL1 in response to metabolic syndrome signals and may promote the progression of cancer through apoptosis recovery or metastasis.
C1 [Dahlquist, Korbyn J., V; Voth, Laura C.; Fee, Amanda J.; Stoeckman, Angela K.] Bethel Univ, Dept Chem, 3900 Bethel Dr MSC 2338, St Paul, MN 55112 USA.
RP Stoeckman, AK (corresponding author), Bethel Univ, Dept Chem, 3900 Bethel Dr MSC 2338, St Paul, MN 55112 USA.
EM a-stoeckman@bethel.edu
OI Dahlquist, Korbyn/0000-0002-0415-1338
FU Sigma Zeta National Science & Mathematics Honor Society Student Research
   Award
FX The Authors would like to thank the 2019 and 2020 Biochemistry II
   classes at Bethel University; Abby Puk, Clayton Neuenschwander, and
   Brooke Toutloff for antibody array results; Jamey Young for the generous
   gift of H4IIE cells; Yonglong Zou and Aaron Boeckermann for assistance
   with the migration assay; Andrew Zieffler and Wade Neiwert for help with
   data analysis; and Laura Listenberger for careful reading of the
   article. This work was supported in part by a Sigma Zeta National
   Science & Mathematics Honor Society Student Research Award.
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NR 37
TC 10
Z9 12
U1 2
U2 4
PU INT INST ANTICANCER RESEARCH
PI ATHENS
PA EDITORIAL OFFICE 1ST KM KAPANDRITIOU-KALAMOU RD KAPANDRITI, PO BOX 22,
   ATHENS 19014, GREECE
SN 0250-7005
EI 1791-7530
J9 ANTICANCER RES
JI Anticancer Res.
PD NOV
PY 2020
VL 40
IS 11
BP 6075
EP 6081
DI 10.21873/anticanres.14628
PG 7
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA OH6EL
UT WOS:000582681900013
PM 33109545
OA Bronze
DA 2025-06-11
ER

PT J
AU Gagliardi, ACM
   Miname, MH
   Santos, RD
AF Gagliardi, Ana C. M.
   Miname, Marcio H.
   Santos, Raul D.
TI Uric acid: A marker of increased cardiovascular risk
SO ATHEROSCLEROSIS
LA English
DT Review
DE Uric acid; Atherosclerosis; Metabolic syndrome; Gout; Renal failure;
   Congestive heart failure; Subclinical atherosclerosis; Cardiovascular
   disease
ID C-REACTIVE PROTEIN; CORONARY-HEART-DISEASE; METABOLIC SYNDROME;
   INSULIN-RESISTANCE; CAROTID ATHEROSCLEROSIS; ENDOTHELIAL DYSFUNCTION;
   ESSENTIAL-HYPERTENSION; MYOCARDIAL-INFARCTION; ALL-CAUSE; ASSOCIATION
AB The relationship between uric acid and cardiovascular disease has been known since the 19th century, after that many authors reported the classical association of gout. hypertension, obesity and cardiovascular disease. With the exception of specific genetic defects in purine metabolism. increased uric acid is generally associated with important risk factors for atherosclerosis like hypertension, abdominal obesity, insulin resistance. the metabolic syndrome and renal failure. Studies have clearly shown an association between increased uric acid concentrations with oxidative stress. endothelial dysfunction, inflammation, subclinical atherosclerosis and an increased risk of cardiovascular events. Increased uric acid levels are independent markers of cardiovascular disease risk. Prospective studies are necessary to show that reduction Of uric acid levels prevent cardiovascular events. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
C1 [Gagliardi, Ana C. M.; Miname, Marcio H.; Santos, Raul D.] Univ Sao Paulo, Lipid Clin Heart Inst InCor, Med Sch Hosp, Sao Paulo, Brazil.
C3 Universidade de Sao Paulo
RP Santos, RD (corresponding author), Lipides InCor, Unidade Clin, HC FMUSP Av Dr Eneas de Carvalho Aguiar,44-2 And, Sao Paulo, Brazil.
EM rdsf@uol.com.br
RI Miname, Marcio/G-4041-2015; Santos, Raul/A-1170-2010
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NR 63
TC 286
Z9 319
U1 2
U2 28
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0021-9150
EI 1879-1484
J9 ATHEROSCLEROSIS
JI Atherosclerosis
PD JAN
PY 2009
VL 202
IS 1
BP 11
EP 17
DI 10.1016/j.atherosclerosis.2008.05.022
PG 7
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 398JW
UT WOS:000262729400003
PM 18585721
DA 2025-06-11
ER

PT J
AU Kaski, JC
AF Kaski, JC
TI Overview of gender aspects of cardiac syndrome X
SO CARDIOVASCULAR RESEARCH
LA English
DT Review
DE coronary disease; gender; hormones; microcirculation
ID NORMAL CORONARY-ARTERIES; INDUCED MYOCARDIAL-ISCHEMIA;
   ENDOTHELIUM-INDEPENDENT RELAXATION; HORMONE REPLACEMENT THERAPY;
   LEFT-VENTRICULAR FUNCTION; CHEST-PAIN; ANGINA-PECTORIS; POSTMENOPAUSAL
   WOMEN; ESTROGEN REPLACEMENT; VASOMOTOR RESPONSES
AB Cardiac syndrome X, a condition defined by the presence of angina-like chest pain, a positive response to stress testing and normal coronary arteriograms, has been shown to occur in approximately 20-30% of angina patients undergoing coronary arteriography. The prevalence of syndrome X is significantly higher in women compared to men. In the majority of patients with chest pain and normal coronary arteriograms, symptoms are likely to be non-cardiac in origin. However, myocardial ischaemia may be the pathogenic mechanism in a proportion of syndrome X patients. Indeed, the clinical characteristics, the ischaemic electrocardiographic findings and the presence of myocardial perfusion defects during stress testing are similar in syndrome X and coronary artery disease patients, Moreover, coronary sinus oxygen saturation abnormalities and pH changes, as well as myocardial lactate production and alterations of cardiac high energy phosphate are seen during stress testing in patients with syndrome X and appear to endorse an ischaemic origin of symptoms in at least a proportion of these individuals. Patients with chest pain and normal coronary arteries have abnormal vasodilatory coronary blood flow response, and an increased sensitivity of the coronary microcirculation to vasoconstrictor stimuli (microvascular angina). Microvascular endothelial dysfunction appears to be responsible for these coronary microcirculation abnormalities. Given the high prevalence of peri- and post-menopausal women in cardiac syndrome X, it has been hypothesized that oestrogen deficiency may play a major role in the pathogenesis of this condition. Oestrogen vasoactive properties involve endothelium-dependent effects and, in postmenopausal women, forearm vasodilatation induced by acetylcholine is potentiated by the acute local administration of intravenous oestradiol. This suggests that endothelium-dependent responses in the peripheral circulation may be modulated by steroid hormones. Impairment of endothelial function in post-menopausal women with syndrome X has been reported by various groups and it could be hypothesized that oestrogen deficiency may contribute to the development of microvascular angina through endothelial dysfunction and that exogenous oestrogen administration may have a beneficial effect in syndrome X patients. This article reviews current knowledge regarding the role of oestrogen deficiency in the pathogenesis of syndrome X and the potential therapeutic role of oestrogen replacement therapy in women with chest pain and normal coronary arteriograms (C) 2002 Published by Elsevier Science B.V.
C1 St George Hosp, Sch Med, Dept Cardiol Sci, Coronary Artery Dis Res Grp, London SW17 0RE, England.
C3 City St Georges, University of London
RP St George Hosp, Sch Med, Dept Cardiol Sci, Coronary Artery Dis Res Grp, Cranmer Terrace, London SW17 0RE, England.
EM jkaski@sghms.ac.uk
RI Kaski, Juan Carlos/LKM-8031-2024
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NR 70
TC 45
Z9 52
U1 0
U2 1
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0008-6363
EI 1755-3245
J9 CARDIOVASC RES
JI Cardiovasc. Res.
PD FEB 15
PY 2002
VL 53
IS 3
SI SI
BP 620
EP 626
AR PII S0008-6363(01)00460-6
DI 10.1016/S0008-6363(01)00460-6
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 541JD
UT WOS:000174980700010
PM 11861032
OA Bronze
DA 2025-06-11
ER

PT J
AU Janssen, FJ
   van der Stelt, M
AF Janssen, Freek J.
   van der Stelt, Mario
TI Inhibitors of diacylglycerol lipases in neurodegenerative and metabolic
   disorders
SO BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
LA English
DT Article
DE Diacylglycerol lipases; 2-Arachidonoylglycerol; Neurodegenerative
   diseases; Neuroinflammation; Obesity; Metabolic syndrome; Drug
   development
ID MONOACYLGLYCEROL LIPASE; ENDOCANNABINOID 2-ARACHIDONOYLGLYCEROL;
   RISK-FACTORS; ALPHA; BIOSYNTHESIS; POTENT; IDENTIFICATION; HYDROLASE;
   ANXIETY; ASSAY
AB 2-Arachidonoylglycerol (2-AG) is an endocannabinoid that activates the cannabinoid receptors type 1 and 2. It also serves as an important lipid precursor for the eicosanoid signaling pathway. Consequently, 2-AG is involved in many physiological functions, including anxiety, food intake, inflammation, memory, pain sensation and neurotransmission. Diacylglycerol lipases (DAGLs) are the main biosynthetic enzymes for 2-AG and their role in several pathophysiological conditions is currently under investigation. In this Digest we review all DAGL inhibitors reported to date and their effects in preclinical models of neurodegeneration and metabolic disorders. (C) 2016 Elsevier Ltd. All rights reserved.
C1 [Janssen, Freek J.; van der Stelt, Mario] Leiden Univ, Leiden Inst Chem, Dept Mol Physiol, POB 9502, NL-2300 RA Leiden, Netherlands.
C3 Leiden University; Leiden University - Excl LUMC
RP van der Stelt, M (corresponding author), Leiden Univ, Leiden Inst Chem, Dept Mol Physiol, POB 9502, NL-2300 RA Leiden, Netherlands.
EM m.van.der.stelt@chem.leidenuniv.nl
OI Janssen, Freek J./0000-0001-5083-3746
FU Netherlands Organisation for Scientific Research (NWO-CW ECHO grant)
FX This work was supported by the The Netherlands Organisation for
   Scientific Research (NWO-CW ECHO grant to M.S.).
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NR 77
TC 25
Z9 27
U1 1
U2 13
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0960-894X
EI 1464-3405
J9 BIOORG MED CHEM LETT
JI Bioorg. Med. Chem. Lett.
PD AUG 15
PY 2016
VL 26
IS 16
BP 3831
EP 3837
DI 10.1016/j.bmcl.2016.06.076
PG 7
WC Chemistry, Medicinal; Chemistry, Organic
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Chemistry
GA DS2FB
UT WOS:000380574400001
PM 27394666
OA Green Published
DA 2025-06-11
ER

PT J
AU Cheurfa, N
   Brenner, GM
   Reis, AF
   Dubois-Laforgue, D
   Roussel, R
   Tichet, J
   Lantieri, O
   Balkau, B
   Fumeron, F
   Timsit, J
   Marre, M
   Velho, G
AF Cheurfa, N.
   Brenner, G. M.
   Reis, A. F.
   Dubois-Laforgue, D.
   Roussel, R.
   Tichet, J.
   Lantieri, O.
   Balkau, B.
   Fumeron, F.
   Timsit, J.
   Marre, M.
   Velho, G.
TI Decreased insulin secretion and increased risk of type 2 diabetes
   associated with allelic variations of the WFS1 gene: the Data from
   Epidemiological Study on the Insulin Resistance Syndrome (DESIR)
   prospective study
SO DIABETOLOGIA
LA English
DT Article
DE Endoplasmic reticulum stress; Genetic epidemiology; Population studies;
   Wolframin
ID ENDOPLASMIC-RETICULUM STRESS; OPTIC ATROPHY; BETA-CELLS; VARIANTS;
   MELLITUS; PROTEIN; COMMON; POLYMORPHISMS; INSIPIDUS; RAMIPRIL
AB We investigated associations of allelic variations in the WFS1 gene with insulin secretion and risk of type 2 diabetes in a general population prospective study.
   We studied 5,110 unrelated French men and women who participated in the prospective Data from Epidemiological Study on the Insulin Resistance Syndrome (DESIR) study. Additional cross-sectional analyses were performed on 4,472 French individuals with type 2 diabetes and 3,065 controls. Three single nucleotide polymorphisms (SNPs) were genotyped: rs10010131, rs1801213/rs7672995 and rs734312.
   We observed statistically significant associations between the major alleles of the three variants and prevalent type 2 diabetes in the DESIR cohort at baseline. Cox analyses showed an association between the G-allele of rs10010131 and incident type 2 diabetes (HR 1.34, 95% CI 1.08-1.70, p = 0.007). Similar results were observed for the G-allele of rs1801213 and the A-allele of rs734312. The GGA haplotype was associated with an increased risk of diabetes as compared with the ACG haplotype (HR 1.26, 95% CI 1.04-1.42, p = 0.02). We also observed statistically significant associations of the three SNPs with plasma glucose, HbA(1c) levels and insulin secretion at baseline and throughout the study in individuals with type 2 diabetes or at risk of developing diabetes. However, no association was observed in those who remained normoglycaemic at the end of the follow-up. Associations between the three variants and type 2 diabetes were replicated in cross-sectional studies of type 2 diabetic patients in comparison with a non-diabetic control group.
   The most frequent haplotype at the haplotype block containing the WFS1 gene modulated insulin secretion and was associated with an increased risk of type 2 diabetes.
C1 [Cheurfa, N.; Brenner, G. M.; Roussel, R.; Fumeron, F.; Marre, M.; Velho, G.] Univ Paris 07, INSERM, Res Unit 695, F-75018 Paris, France.
   [Brenner, G. M.] Fed Univ Hlth Sci Porto Alegre, Postgradut Program Hlth Sci, Porto Alegre, RS, Brazil.
   [Reis, A. F.] Univ Fed Sao Paulo, Mol Endocrinol Lab, Sao Paulo, Brazil.
   [Dubois-Laforgue, D.; Tichet, J.] Assistance Publ Hop Paris Cochin Hosp, Dept Immunol & Diabetol, Paris, France.
   [Dubois-Laforgue, D.; Timsit, J.] Univ Paris 05, UFR Med, Paris, France.
   [Roussel, R.; Fumeron, F.; Marre, M.] Univ Paris 07, UFR Med, Paris, France.
   [Roussel, R.; Marre, M.] Assistance Publ Hop Paris Bichat Hosp, Dept Endocrinol Diabetol & Nutr, Paris, France.
   [Tichet, J.; Lantieri, O.] Inst Inter Reg Sante IRSA, La Riche, France.
   [Balkau, B.] INSERM, U1018, CESP, Ctr Res Epidemiol & Populat Hlth, Villejuif, France.
   [Balkau, B.] Univ Paris 11, UMRS 1018, Villejuif, France.
C3 Institut National de la Sante et de la Recherche Medicale (Inserm);
   Universite Paris Cite; Universidade Federal de Sao Paulo (UNIFESP);
   Assistance Publique Hopitaux Paris (APHP); Universite Paris Cite;
   Hopital Universitaire Cochin - APHP; Universite Paris Cite; Universite
   Paris Cite; Assistance Publique Hopitaux Paris (APHP); Universite Paris
   Cite; Hopital Universitaire Bichat-Claude Bernard - APHP; Universite
   Paris Saclay; Institut National de la Sante et de la Recherche Medicale
   (Inserm); Institut National de la Sante et de la Recherche Medicale
   (Inserm); Universite Paris Saclay
RP Velho, G (corresponding author), Univ Paris 07, INSERM, Res Unit 695, 16 Rue Henri Huchard, F-75018 Paris, France.
EM gilberto.velho@inserm.fr
RI Greiver, Michelle/N-8764-2015; Fumeron, Frederic/AAC-6882-2019; Velho,
   Gilberto/Q-6724-2017
OI Marre, Michel/0000-0002-3071-1837; Fumeron,
   Frederic/0000-0002-7916-4619; Velho, Gilberto/0000-0001-8811-363X;
   Dubois-Laforgue, Daniele/0000-0003-3287-6309
FU Societe Francophone du Diabete (SFD - Alfediam); Association Diabete
   Risque Vasculaire (ADRV), France; CAPES, Brazil [1798-09-0]; INSERM;
   CNAMTS; Lilly; Novartis Pharma; Sanofi-Aventis; INSERM (Reseaux en Sante
   Publique, Interactions entre les determinants de la sante); Association
   Diabete Risque Vasculaire; Federation Francaise de Cardiologie; La
   Fondation de France; ALFEDIAM; ONIVINS; Ardix Medical; Bayer
   Diagnostics; Becton Dickinson; Cardionics; Merck Sante; Novo Nordisk;
   Pierre Fabre; Roche; Topcon
FX N. Cheurfa was supported by grants from Societe Francophone du Diabete
   (SFD - Alfediam) and Association Diabete Risque Vasculaire (ADRV),
   France. A. F. Reis was supported by grant 1798-09-0 from CAPES, Brazil.
   The DESIR study has been financed by: INSERM contracts with CNAMTS,
   Lilly, Novartis Pharma and Sanofi-Aventis; and by INSERM (Reseaux en
   Sante Publique, Interactions entre les determinants de la sante,
   Cohortes Sante TGIR 2008), the Association Diabete Risque Vasculaire,
   the Federation Francaise de Cardiologie, La Fondation de France,
   ALFEDIAM, ONIVINS, Ardix Medical, Bayer Diagnostics, Becton Dickinson,
   Cardionics, Merck Sante, Novo Nordisk, Pierre Fabre, Roche, Topcon.
   Analysis and interpretation of the data were done without the
   participation of these organisations.
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NR 32
TC 24
Z9 29
U1 0
U2 2
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0012-186X
EI 1432-0428
J9 DIABETOLOGIA
JI Diabetologia
PD MAR
PY 2011
VL 54
IS 3
BP 554
EP 562
DI 10.1007/s00125-010-1989-0
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 716PX
UT WOS:000286987000013
PM 21127832
OA Bronze
DA 2025-06-11
ER

PT J
AU Elsamna, ST
   Suri, P
   Mir, GS
   Roden, DF
   Paskhover, B
AF Elsamna, Samer T.
   Suri, Pooja
   Mir, Ghayoour S.
   Roden, Dylan F.
   Paskhover, Boris
TI Evaluating the impact of metabolic syndrome on postoperative
   thyroidectomy outcomes
SO HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND
   NECK
LA English
DT Article
DE metabolic surgery; metabolic syndrome; otolaryngology; outcomes;
   thyroidectomy
ID SHORT-TERM DIET; QUALITY IMPROVEMENT PROGRAM; EXERCISE INTERVENTION;
   OUTPATIENT THYROIDECTOMY; OXIDATIVE STRESS; UNITED-STATES; MEN;
   COMPLICATIONS; INFLAMMATION; INPATIENT
AB Objective Metabolic syndrome (MetS) has previously been linked to increased risk of postoperative morbidity and mortality in other surgical undertakings. Because MetS is a consequence of endocrine dysfunction, and given the thyroid's crucial role in endocrine homeostasis, we sought to evaluate the association between MetS and postoperative outcomes of thyroidectomy.
   Methods Data were acquired from the ACS-NSQIP database from years 2005 to 2017. Patients with obesity, diabetes, and hypertension were defined as having MetS. Odds ratios (OR) were obtained for outcomes to quantify risk with multivariate logistic regression.
   Results Outcomes significantly affected by MetS included overall complication (OR: 2.00), extended postoperative stay (OR: 1.52), medical complication (OR: 1.48), surgical complication (OR: 1.62), and mortality (OR: 2.33).
   Conclusions Patients with MetS undergoing thyroidectomy are at increased risk of an increased length of stay, overall complications, and mortality.
C1 [Elsamna, Samer T.; Suri, Pooja; Mir, Ghayoour S.; Roden, Dylan F.; Paskhover, Boris] Rutgers New Jersey Med Sch, Dept Otolaryngol Head & Neck Surg, 90 Bergen St,Suite 8100, Newark, NJ 07103 USA.
C3 Rutgers University System; Rutgers University New Brunswick; Rutgers
   University Biomedical & Health Sciences
RP Paskhover, B (corresponding author), Rutgers New Jersey Med Sch, Dept Otolaryngol Head & Neck Surg, 90 Bergen St,Suite 8100, Newark, NJ 07103 USA.
EM borpas@njms.rutgers.edu
RI Roden, Dylan/ABD-1997-2020
OI Elsamna, Samer/0000-0003-4643-8529; Mir, Ghayoour/0000-0003-3713-6772
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NR 48
TC 14
Z9 16
U1 1
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1043-3074
EI 1097-0347
J9 HEAD NECK-J SCI SPEC
JI Head Neck-J. Sci. Spec. Head Neck
PD APR
PY 2021
VL 43
IS 4
BP 1271
EP 1279
DI 10.1002/hed.26588
EA DEC 2020
PG 9
WC Otorhinolaryngology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Otorhinolaryngology; Surgery
GA RB1QA
UT WOS:000602561300001
PM 33368806
DA 2025-06-11
ER

PT J
AU Pan, PP
   Zhan, QT
   Le, F
   Zheng, YM
   Jin, F
AF Pan, Pei-Pei
   Zhan, Qi-Tao
   Le, Fang
   Zheng, Ying-Ming
   Jin, Fan
TI Angiotensin-Converting Enzymes Play a Dominant Role in Fertility
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE angiotensin-converting enzyme; fertility; metabolic syndrome;
   renin-angiotensin system; angiotensin-converting enzyme inhibitor
ID POLYCYSTIC-OVARY-SYNDROME; OOCYTE MATURATION; ACE-INHIBITOR; RECEPTOR
   MAS; HUMAN TESTIS; INSULIN-RESISTANCE; METABOLIC SYNDROME; OXIDATIVE
   STRESS; PREGNANCY RATE; SPERM
AB According to the World Health Organization, infertility, associated with metabolic syndrome, has become a global issue with a 10%-20% incidence worldwide. An accumulating body of evidence has shown that the renin-angiotensin system is involved in the fertility problems observed in some populations. Moreover, alterations in the expression of angiotensin-converting enzyme-1, angiotensin-converting enzyme-2, and angiotensin-converting enzyme-3 might be one of the most important mechanisms underlying both female and male infertility. However, as a pseudogene in humans, further studies are needed to explore whether the abnormal angiotensin-converting enzyme-3 gene could result in the problems of human reproduction. In this review, the relationship between angiotensin-converting enzymes and fertile ability is summarized, and a new procedure for the treatment of infertility is discussed.
C1 [Pan, Pei-Pei; Zhan, Qi-Tao; Le, Fang; Zheng, Ying-Ming; Jin, Fan] Zhejiang Univ, Womens Hosp, Sch Med, Dept Reprod Endocrinol, Hangzhou 310006, Zhejiang, Peoples R China.
C3 Zhejiang University
RP Jin, F (corresponding author), Zhejiang Univ, Womens Hosp, Sch Med, Dept Reprod Endocrinol, 1 Xueshi Rd, Hangzhou 310006, Zhejiang, Peoples R China.
EM 21118206@zju.edu.cn; greamygirl@zju.edu.cn; lefang851021@126.com;
   20918528@zju.edu.cn; jinfan@zju.edu.cn
FU National Basic Research Program of China [2012CB944 901]; National
   Natural Science Program of China [81070532, 81070541]; Natural Science
   Program of Zhejiang Province, China [Y2100822]; Zhejiang Provincial
   Natural Science Foundation of China [LZ13H040001]
FX This work was supported by the National Basic Research Program of China
   (No. 2012CB944 901); the National Natural Science Program of China (No.
   81070532; No. 81070541); Natural Science Program of Zhejiang Province,
   China (No.Y2100822); and Zhejiang Provincial Natural Science Foundation
   of China (No. LZ13H040001).
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NR 101
TC 82
Z9 87
U1 1
U2 38
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD OCT
PY 2013
VL 14
IS 10
BP 21071
EP 21086
DI 10.3390/ijms141021071
PG 16
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 274QK
UT WOS:000328620900099
PM 24152441
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Richette, P
   Perez-Ruiz, F
AF Richette, P.
   Perez-Ruiz, F.
TI Serum uric acid and metabolic risk
SO CURRENT MEDICAL RESEARCH AND OPINION
LA English
DT Review
DE Hyperuricemia; Metabolic risk; Type 2 diabetes; Uric acid
ID 3RD NATIONAL-HEALTH; C-REACTIVE PROTEIN; ENDOTHELIAL DYSFUNCTION;
   XANTHINE-OXIDASE; OXIDATIVE STRESS; MEAT INTAKE; CARDIOVASCULAR-DISEASE;
   INSULIN-RESISTANCE; DIETARY PATTERNS; BLOOD-PRESSURE
AB Objectives:
   This review presents the information available on the role of uric acid (UA) on metabolic risk and on the link between hyperuricemia and metabolic syndrome.
   Methods:
   Key papers for inclusion were identified by a PubMed search and articles were selected according to their relevance for the topic, according to the authors' judgment.
   Results and conclusions:
   An elevated UA is both strongly associated and predictive of the metabolic syndrome, and increasing evidence suggests that UA may have a causal role. The classical viewpoint that UA is simply an innocuous marker of metabolic syndrome that should not even be measured will likely have to be modified. Lowering UA may be a novel treatment target for preventing diabetes and justify prospective clinical trials on the possible benefits of the measurement and lowering of serum UA on multiple chronic disease end points.
C1 [Richette, P.] Univ Paris 07, Hop Lariboisiere, AP HP, UFR Med,Federat Rhumatol, F-75475 Paris, France.
   [Perez-Ruiz, F.] Hosp Univ Cruces, Pecs, Hungary.
C3 Universite Paris Cite; Assistance Publique Hopitaux Paris (APHP);
   Hopital Universitaire Lariboisiere-Fernand-Widal - APHP
RP Richette, P (corresponding author), Univ Paris 07, Hop Lariboisiere, AP HP, UFR Med,Federat Rhumatol, F-75475 Paris, France.
EM pascal.richette@lrb.aphp.fr
RI Perez-Ruiz, Fernando/X-1980-2019
OI Perez-Ruiz, Fernando/0000-0002-5268-1894; Richette,
   Pascal/0000-0003-2132-4074
FU Menarini International; Asociacion de Reumatologos del Hospital de
   Cruces; Ministerio de Sanidad; Gobierno de Espana; Sociedad Espanola de
   Reumatologia
FX Menarini International provided funding for editorial assistance.The
   authors on this manuscript have received no remuneration for their role
   in the development of this work. PR has no relevant financial
   relationships to disclose. F.P.-R. has disclosed that he has received
   grant/research funding from Asociacion de Reumatologos del Hospital de
   Cruces; Ministerio de Sanidad; Gobierno de Espana; and Sociedad Espanola
   de Reumatologia. He has also been a consultant to Menarini, AstraZeneca,
   Metabolex and Pfizer; and involved in educational programs for Menarini,
   Savient and Sociedad Espanola de Reumatologia.
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NR 58
TC 18
Z9 22
U1 0
U2 14
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0300-7995
EI 1473-4877
J9 CURR MED RES OPIN
JI Curr. Med. Res. Opin.
PD APR
PY 2013
VL 29
SU 3
BP 9
EP 15
DI 10.1185/03007995.2013.790801
PG 7
WC Medicine, General & Internal; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Research & Experimental Medicine
GA 136IF
UT WOS:000318354900003
PM 23611367
DA 2025-06-11
ER

PT J
AU Chen, DD
   Zhang, H
   Cui, NQ
   Song, F
   Tang, LW
   Shao, J
   Wu, JJ
   Guo, PP
   Liu, N
   Wang, XY
   Ye, ZH
AF Chen, Dandan
   Zhang, Hui
   Cui, Nianqi
   Song, Feng
   Tang, Leiwen
   Shao, Jing
   Wu, Jingjie
   Guo, Pingping
   Liu, Na
   Wang, Xiyi
   Ye, Zhihong
TI Development of a behavior change intervention to improve physical
   activity adherence in individuals with metabolic syndrome using the
   behavior change wheel
SO BMC PUBLIC HEALTH
LA English
DT Article
DE Metabolic syndrome; Physical activity adherence; Behavioral Change
   Wheel; Mobile health
ID EXERCISE; MANAGEMENT; METAANALYSIS; PREVENTION; REDUCTION; NUTRITION;
   CONSENSUS; STRESS
AB Background Adherence to physical activity is inadequate in adults with metabolic syndrome. Adherence to physical activity recommendations is crucial and can result in improved health outcomes and reduced medical burdens. A comprehensive behavior change intervention, including identifying determinants of adherence to physical activity recommendations, intervention options, intervention content and implementation options, was imperative for enhancing physical activity adherence. The aim of the study is to develop an intervention to increase physical activity adherence among individuals with metabolic syndrome. Methods The study followed the eight steps of the Behavior Change Wheel guide, including defining the problem in behavioral terms (Step 1), selecting target behavior (Step 2), specifying target behavior (Step 3), identifying what needs to change (Step 4), identifying intervention functions (Step 5), identifying policy categories (Step 6), identifying behavior change techniques (Step 7), and determining model of delivery (Step 8). The semi-structured, in-depth interviews were employed to identify the determinants of adherence to physical activity among twenty-eight individuals with metabolic syndrome based on capability, opportunity, motivation and behavior model. Next, the intervention functions and policy categories were chosen to address these determinants. Finally, behavior change techniques were selected to assist in the delivery of the intervention functions and be translated into intervention content. Results Our study identified eighteen facilitators and fifteen barriers to physical activity adherence. It resulted in the selection of seven intervention functions and nineteen behavior change techniques for the intervention program. Then, the current study identified an app as the delivery mode. Finally, a behavioral change intervention was generated for individuals with metabolic syndrome to increase physical activity recommendation adherence. Conclusions The Behavior Change Wheel provided a systematic approach to designing a behavior change intervention, which helped improve the health outcomes and reduce medical burdens and economic burdens among individuals with metabolic syndrome. The findings suggested that potential intervention should pay special attention to increasing knowledge in metabolic syndrome, imparting skills of physical activity, offering a supportive environment, and providing suggestions on regular physical activity using the appropriate behavior change techniques. A feasibility study will be undertaken to assess the acceptability and effectiveness of the intervention program in the future.
C1 [Chen, Dandan; Tang, Leiwen; Wu, Jingjie; Ye, Zhihong] Zhejiang Univ, Affiliated Sir Run Run Shaw Hosp, Nursing Dept, Sch Med, 3 East Qingchun Rd, Hangzhou 310020, Peoples R China.
   [Zhang, Hui] Guizhou Prov Peoples Hosp, Dept Cardiol, 83 East Zhongshan Rd, Guiyang 550002, Peoples R China.
   [Cui, Nianqi] Zhejiang Univ, Nursing Dept, Sch Med, Affiliated Hosp 2, 88 Jiefang Rd, Hangzhou 310009, Peoples R China.
   [Song, Feng] Natl Univ Malaysia, Fac Med, Kuala Lumpur, Malaysia.
   [Song, Feng] Yunnan Coll Business Management, Fac Med, 296 Haitun Rd, Kunming 650106, Yunnan, Peoples R China.
   [Shao, Jing] Zhejiang Univ, Sch Nursing, Sch Med, 866 Yuhangtang Rd, Hangzhou 310012, Peoples R China.
   [Guo, Pingping] Zhejiang Univ, Womens Hosp, Sch Med, 1 Xueshi Rd, Hangzhou 310006, Peoples R China.
   [Liu, Na] Chongqing Med Univ, Nursing Dept, Affiliated Hosp 2, 76 Linjiang Rd, Chongqing, Peoples R China.
   [Wang, Xiyi] Shanghai Jiao Tong Univ, Sch Nursing, Chongqing South Rd 227, Shanghai, Peoples R China.
C3 Zhejiang University; Zhejiang University; Universiti Kebangsaan
   Malaysia; Zhejiang University; Zhejiang University; Chongqing Medical
   University; Shanghai Jiao Tong University
RP Ye, ZH (corresponding author), Zhejiang Univ, Affiliated Sir Run Run Shaw Hosp, Nursing Dept, Sch Med, 3 East Qingchun Rd, Hangzhou 310020, Peoples R China.
EM yezh@zju.edu.cn
RI Wang, Xiyi/HDM-3904-2022; Wu, Jingjie/G-8274-2016
OI Wang, Xiyi/0000-0002-6470-8556; Cui, Nianqi/0000-0002-7963-4887
FU Zhejiang province medical technology project in 2019 [WKJ-ZJ-1925];
   National Social Science Fund of China [20BGL275]; National Natural
   Science Foundation of China [72004193]; Shanghai Jiao Tong University
   School of Medicine-Nursing Development Program; Shanghai Sailing Program
   [21YF1422400]; Guizhou Provincial People's Hospital [2022-18]
FX This study was supported by research grants from the Zhejiang province
   medical technology project (WKJ-ZJ-1925) in 2019, the National Social
   Science Fund of China (20BGL275), the National Natural Science
   Foundation of China (72004193), Yuan Nei Ren Cai Xiang Mu of Guizhou
   Provincial People's Hospital(2022-18), Shanghai Jiao Tong University
   School of Medicine-Nursing Development Program, and Shanghai Sailing
   Program (21YF1422400).
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NR 70
TC 8
Z9 8
U1 2
U2 32
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2458
J9 BMC PUBLIC HEALTH
JI BMC Public Health
PD SEP 14
PY 2022
VL 22
IS 1
AR 1740
DI 10.1186/s12889-022-14129-1
PG 30
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA 4N3GR
UT WOS:000853908000004
PM 36104817
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Dimina, LJ
   Leray, V
   Voute, M
   David, J
   Blavignac, C
   Farges, MC
   Rossary, A
   Tsikas, D
   Rémond, D
   Pickering, G
   Mariotti, F
AF Dimina, Laurianne Jolata
   Leray, Vincent
   Voute, Marion
   David, Jeremie
   Blavignac, Christelle
   Farges, Marie-Chantal
   Rossary, Adrien
   Tsikas, Dimitrios
   Remond, Didier
   Pickering, Gisele
   Mariotti, Francois
TI Dietary Protein in a Challenge Meal Does Not Alleviate Postprandial
   Impairments in Vascular Endothelial Function in Healthy Older Adults
   with Cardiometabolic Risk: A Randomized Crossover-Controlled Trial
SO JOURNAL OF NUTRITION
LA English
DT Article
DE elderly people; plant protein blend; milk protein; FMD; vascular
   function; low-grade inflammation; oxidative stress; RT-QPCR; blood
   plasma
ID PERIPHERAL ARTERIAL DYSFUNCTION; FLOW-MEDIATED DILATATION; OXIDATIVE
   STRESS; INSULIN-RESISTANCE; OVERWEIGHT ADULTS; NITRIC-OXIDE; FAT;
   SUPPLEMENTATION; INGESTION; ARGININE
AB Background: Postprandial vascular endothelial dysfunction is an early marker of atherosclerosis. Meal protein has been reported to reduce endothelial dysfunction in adults, and the effect could be mediated by the amino acid content. Objectives: This trial aims to assess the effect of a specifically designed plant-protein blend that contains high leucine, arginine, and cysteine on postprandial endothelial function in the elderly. Methods: In a randomized, double-blind, 3-period crossover (2-wk washout), controlled trial, we compared the vascular effects of 3 high- saturated-fat high-sucrose (HFHS) meals containing either our specific plant-protein blend, or milk protein, or without added protein. The trial was conducted on 29 healthy adults aged > 65 y presenting >= 2 cardiometabolic risk factors. Postprandial vascular function was evaluated at fasting, 3 h, and 5 h postprandially, using brachial fl ow-mediated dilation (FMD), hand microvascular reactivity (using Flowmetry Laser Doppler, FLD), and fi nger reactive hyperemia index (using Peripheral Arterial Tonometry, RHI). Immune cell count and gene expression in peripheral blood mononuclear cells (PBMCs) were also assessed postprandially. Data were analyzed using mixed linear models with repeated measurements on participants for meal composition and time of sampling. This trial was registered at clinicaltrials.gov as NCT04923555. Results: FMD incremental AUC value decreased after meals (time effect P < 0.01), with no significant differences between meals. RHI also decreased with time (P < 0.01). PBMC count and monocyte chemoattractant protein-1 (MCP1), IL-1 (3 , and IL-6 expression increased after meals showing postprandial endothelial activation (P < 0.05). Overall, meal composition had no effect on any of the postprandial changes (Ps>0.10). Conclusions: In healthy adults aged > 65 y presenting cardiometabolic risk, adding protein to an HFHS challenge meal does not mitigate postprandial impairments in vascular endothelial function and inflammatory activation. Further studies are needed to explore the potential differences with younger adults.
C1 [Dimina, Laurianne Jolata; Mariotti, Francois] Univ Paris Saclay, AgroParisTech, INRAE, UMR PNCA, Palaiseau, France.
   [Leray, Vincent; Voute, Marion; Pickering, Gisele] Univ Hosp Clermont Ferrand, Platform Clin Invest Dept, INSERM CIC 1405, Clermont Ferrand, France.
   [David, Jeremie; Farges, Marie-Chantal; Rossary, Adrien; Remond, Didier] Univ Clermont Auvergne, Unite Nutr Humaine, INRAE, CRNH Auvergne,UNH, Clermont Ferrand, France.
   [Blavignac, Christelle] UCA PARTNER, Ctr Imagerie Cellulaire Sante, Clermont Ferrand, France.
   [Tsikas, Dimitrios] Hannover Med Sch, Core Unit Prote, Inst Toxicol, Hannover, Germany.
   [Pickering, Gisele] Univ Clermont Auvergne, INSERM 1107, Clermont Ferrand, France.
C3 Universite Paris Saclay; AgroParisTech; INRAE; Universite Clermont
   Auvergne (UCA); CHU Clermont Ferrand; Institut National de la Sante et
   de la Recherche Medicale (Inserm); INRAE; Universite Clermont Auvergne
   (UCA); Hannover Medical School; Universite Clermont Auvergne (UCA);
   Institut National de la Sante et de la Recherche Medicale (Inserm)
RP Mariotti, F (corresponding author), Univ Paris Saclay, AgroParisTech, INRAE, UMR PNCA, Palaiseau, France.
EM francois.mariotti@agroparistech.fr
RI Rossary, Adrien/A-2863-2011; Mariotti, François/F-9651-2017; Remond,
   Didier/LJL-0035-2024
OI Remond, Didier/0000-0003-4430-0067
FU French Research Agency (ANR) [ANR-18-CE21-0001]; Agence Nationale de la
   Recherche (ANR) [ANR-18-CE21-0001] Funding Source: Agence Nationale de
   la Recherche (ANR)
FX This work was funded by the French Research Agency (ANR) , project
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NR 72
TC 0
Z9 0
U1 2
U2 2
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0022-3166
EI 1541-6100
J9 J NUTR
JI J. Nutr.
PD DEC
PY 2024
VL 154
IS 12
BP 3664
EP 3680
DI 10.1016/j.tjnut.2024.10.018
EA DEC 2024
PG 17
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA O8Y8G
UT WOS:001373923800001
PM 39424070
DA 2025-06-11
ER

PT J
AU Allen, J
   Trenga, CA
   Peretz, A
   Sullivan, JH
   Carlsten, CC
   Kaufman, JD
AF Allen, Jason
   Trenga, Carol A.
   Peretz, Alon
   Sullivan, Jeffrey H.
   Carlsten, Christopher C.
   Kaufman, Joel D.
TI Effect of diesel exhaust inhalation on antioxidant and oxidative stress
   responses in adults with metabolic syndrome
SO INHALATION TOXICOLOGY
LA English
DT Article
DE Air pollution; diesel exhaust; oxidative stress; antioxidants; metabolic
   syndrome; controlled exposure experiment; crossover studies; vehicle
   emissions/toxicity; adult; biological markers; human; male; female
ID PARTICULATE AIR-POLLUTION; SHORT-TERM EXPOSURE; HEALTHY-HUMAN
   VOLUNTEERS; DNA-DAMAGE; HEART-DISEASE; IN-VIVO; MARKERS;
   8-HYDROXY-2'-DEOXYGUANOSINE; INFLAMMATION; BIOMARKER
AB Background: Traffic-related air pollution is associated with cardiovascular morbidity and mortality. Although the biological mechanisms are not well understood, oxidative stress may be a primary pathway. Subpopulations, such as individuals with metabolic syndrome (MeS), may be at increased risk of adverse effects associated with air pollution. Our aim was to assess the relationship between exposure to diesel exhaust (DE) and indicators of systemic antioxidant and oxidative responses in adults with MeS. We hypothesized that DE exposure would result in greater oxidative stress and antioxidant responses compared with filtered air (FA).
   Methods: Ten adult subjects with MeS were exposed on separate days for two hours to FA or DE (at 200 mu g/m3), in a double blind, crossover experiment. Urinary 8-isoPGF2a (F2-isoprostanes), and 8-hydroxy-2'-deoxyguanosine (8-OHdG) were assessed as markers of oxidative stress at 3 hrs and 22 hrs, respectively, after exposure initiation. To assess the short-term antioxidant response we analyzed plasma ascorbic acid (AA) 90 minutes after exposure initiation. All outcomes were compared to pre-exposure levels, and mean changes were compared between FA and DE exposures.
   Results: Mean changes in urinary F2-isoprostanes (ng/mg creatinine), (-0.05 [95% CI = -0.29, 0.15]), and 8-OHdG (mu g/g creatinine) (-0.09 [-0.13, 0.31]), were not statistically significant. Mean changes in plasma AA (mg/dl) were also not significant (-0.02 [-0.78, 0.04]).
   Conclusions: In this carefully controlled experiment, we did not detect significant changes in oxidative stress or systemic antioxidant responses in subjects with MeS exposed to 200 mu g/m3 DE.
C1 [Allen, Jason; Trenga, Carol A.; Peretz, Alon; Sullivan, Jeffrey H.; Carlsten, Christopher C.; Kaufman, Joel D.] Univ Washington, Dept Environm & Occupat Hlth Sci, Seattle, WA 98195 USA.
   [Carlsten, Christopher C.] Univ Washington, Dept Med, Seattle, WA 98195 USA.
C3 University of Washington; University of Washington Seattle; University
   of Washington; University of Washington Seattle
RP Allen, J (corresponding author), Univ Washington, Dept Environm & Occupat Hlth Sci, 4225 Roosevelt Way NE,Suite 100,Box 354695, Seattle, WA 98195 USA.
EM drjnd@u.washington.edu
RI Kaufman, Joel/B-5761-2008
OI Kaufman, Joel/0000-0003-4174-9037
FU Environmental Protection Agency [R830954, R827355]; National Institute
   of Environmental Health Sciences [K24ES013195, P30ES07033]; National
   Center for Complementary and Alternative Medicine [F32AT003366-01];
   National Center for Research Resources [M01RR00037]; National Institute
   of Diabetes and Digestive and Kidney Diseases [P30DK035816]; EPA
   [R830954, 1100018] Funding Source: Federal RePORTER
FX Support for this study was provided by grants R830954 and R827355 from
   the Environmental Protection Agency, K24ES013195 and P30ES07033 from the
   National Institute of Environmental Health Sciences, F32AT003366-01 from
   the National Center for Complementary and Alternative Medicine,
   M01RR00037 from the National Center for Research Resources, and
   P30DK035816 from the National Institute of Diabetes and Digestive and
   Kidney Diseases. The authors declare that they have no competing
   interests.
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NR 41
TC 30
Z9 33
U1 0
U2 9
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0895-8378
EI 1091-7691
J9 INHAL TOXICOL
JI Inhal. Toxicol.
PD NOV
PY 2009
VL 21
IS 13
BP 1061
EP 1067
DI 10.3109/08958370902721424
PG 7
WC Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Toxicology
GA 543ZA
UT WOS:000273619300001
PM 19852547
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Wang, HS
   Ruan, XY
   Li, YL
   Cheng, JJ
   Mueck, AO
AF Wang, Husheng
   Ruan, Xiangyan
   Li, Yanglu
   Cheng, Jiaojiao
   Mueck, Alfred O.
TI Oxidative stress indicators in Chinese women with PCOS and correlation
   with features of metabolic syndrome and dependency on lipid patterns
SO ARCHIVES OF GYNECOLOGY AND OBSTETRICS
LA English
DT Article
DE Oxidative stress; Polycystic ovarian syndrome; Metabolic syndrome;
   Superoxide dismutase
ID POLYCYSTIC-OVARY-SYNDROME; NUTRITION EXAMINATION SURVEY;
   INSULIN-RESISTANCE; NATIONAL-HEALTH; PREVALENCE; MARKERS; DYSLIPIDEMIA;
   PHENOTYPES; DIAGNOSIS; KOREA
AB Objective The aim was to investigate oxidative stress indicators in the blood of women with PCOS without and with metabolic syndrome (MS) and their dependency on lipids, comparing with healthy women. To our knowledge, this is the first study on this topic. Methods This was a cross-sectional study, and blood tests performed were double-blind. Within 3 months, 205 PCOS patients, from whom 55 also had MS, and 65 healthy women (control) were recruited. Malondialdehyde (MDA) was assessed as an important oxidative indicator, and superoxide dismutase (SOD), total antioxidant activity (TAA), vitamin C (VC), vitamin E (VE) and retinol (RET) as antioxidative indicators. Their correlation with features of MS was analyzed including their dependency on lipid pattern. Results SOD, TAA, VE and RET in the PCOS group and PCOS + MS group were lower and MDA higher than in the control group (p < 0.05). SOD, VE and RET were the lowest in PCOS + MS group (p < 0.05). Thus, patients in this group had the highest oxidative stress levels but the lowest antioxidative capacity. SOD and TAA significantly decreased with increase of triglycerides (TG) and LDL-C in the PCOS + MS group (p < 0.05), but without dependency on HDL-C. Stepwise multiple linear regression analysis confirmed the different expression of oxidative stress in the three groups and decrease of SOD from control to PCOS group to PCOS + MS group, being associated with an increase of TG. Conclusions MS can accelerate the oxidative stress process in patients with PCOS and decrease the antioxidative capacity. The decreased antioxidant capacity in PCOS with MS is related to increased TG and LDL-C.
C1 [Wang, Husheng; Ruan, Xiangyan; Li, Yanglu; Cheng, Jiaojiao; Mueck, Alfred O.] Capital Med Univ, Beijing Obstet & Gynecol Hosp, Dept Gynecol Endocrinol, Beijing 100026, Peoples R China.
   [Ruan, Xiangyan; Mueck, Alfred O.] Univ Hosp Tuebingen, Dept Womens Hlth, D-72076 Tubingen, Germany.
C3 Capital Medical University; Eberhard Karls University of Tubingen;
   Eberhard Karls University Hospital
RP Ruan, XY (corresponding author), Capital Med Univ, Beijing Obstet & Gynecol Hosp, Dept Gynecol Endocrinol, Beijing 100026, Peoples R China.; Ruan, XY (corresponding author), Univ Hosp Tuebingen, Dept Womens Hlth, D-72076 Tubingen, Germany.
EM ruanxiangyan@163.com
RI Cheng, Jiaojiao/AAA-8243-2021
OI Ruan, Xiangyan/0000-0001-7777-247X
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NR 32
TC 33
Z9 34
U1 0
U2 13
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0932-0067
EI 1432-0711
J9 ARCH GYNECOL OBSTET
JI Arch. Gynecol. Obstet.
PD NOV
PY 2019
VL 300
IS 5
BP 1413
EP 1421
DI 10.1007/s00404-019-05305-7
PG 9
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA JH2JP
UT WOS:000492596500027
PM 31549221
DA 2025-06-11
ER

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AF Torres Flister, Karla Frida
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   dos Santos, Pamela Costa
   Vale, Caroline Castro
   Kajihara, Daniela
   Debbas, Victor
   Martins Laurindo, Francisco Rafael
   de Andrade Paes, Antonio Marcus
TI Long-term exposure to high-sucrose diet down-regulates hepatic
   endoplasmic reticulum-stress adaptive pathways and potentiates de
   novo lipogenesis in weaned male mice
SO JOURNAL OF NUTRITIONAL BIOCHEMISTRY
LA English
DT Article
DE Nonalcoholic fatty liver disease; Endoplasmic reticulum stress; De novo
   lipogenesis; High-sucrose diet; Microvesicular steatosis; Metabolic
   syndrome
ID FATTY LIVER-DISEASE; UNFOLDED PROTEIN RESPONSE; DEVELOPMENTAL ORIGINS;
   INSULIN-RESISTANCE; RICH DIET; MORPHOLOGICAL-CHANGES; SREBP-1C
   ACTIVATION; NLRP3 INFLAMMASOME; METABOLIC SYNDROME; FOOD-INTAKE
AB Childhood consumption of added sugars, such as sucrose, has been associated to increased risk of metabolic syndrome (MetS) and nonalcoholic fatty liver disease (NAFLD). Although the mechanisms underlying NAFLD onset are incompletely defined, recent evidence has proposed a role for the endoplasmic reticulum (ER) stress. Thus, the present study sought to investigate the metabolic outcomes of high-sucrose intake on weaned Swiss mice fed a 25% sucrose diet for 30, 60 and 90 days in comparison to regular chow-fed controls. High-sucrose feeding promoted progressive metabolic and oxidative disturbances, starting from fasting and fed hyperglycemia, hyperinsulinemia, glucose intolerance and increased adiposity at 30-days; passing by insulin resistance, hypertriglyceridemia and NAFLD onset at 60 days; until late hepatic oxidative damage at 90 days. In parallel, assessment of transcriptional and/or translational levels of de novo lipogenesis (DNL) and ER stress markers showed up-regulation of both fatty acid synthesis (ChREBP and SCD1) and oxidation (PPAR alpha and CPT-1 alpha), as well as overexpression of unfolded protein response sensors (IRE1 alpha, PERK and ATF6), chaperones (GRP78 and PDIA1) and antioxidant defense (NRF2) genes at 30 days. At 60 days, fatty acid oxidation genes were down-regulated, and ER stress switched over toward a proapoptotic pattern via up-regulation of BAK protein and CHOP gene levels. Finally, down-regulation of both NRF2 and CPT-1 alpha protein levels led to late up-regulation of SREBP-1c and exponential raise of fatty acids synthesis. In conclusion, our study originally demonstrates a temporal relationship between DNL and ER stress pathways toward MetS and NAFLD development on weaned rats fed a high-sucrose diet. (C) 2018 Elsevier Inc. All rights reserved.
C1 [Torres Flister, Karla Frida; Serra Pinto, Bruno Araujo; Franca, Lucas Martins; Ferreira Coelho, Caio Fernando; dos Santos, Pamela Costa; Vale, Caroline Castro; de Andrade Paes, Antonio Marcus] Univ Fed Maranhao, Dept Physiol Sci, Lab Expt Physiol, Sao Luis, MA, Brazil.
   [Kajihara, Daniela; Debbas, Victor; Martins Laurindo, Francisco Rafael] Univ Sao Paulo, Sch Med, Heart Inst, Lab Vasc Biol, Sao Paulo, SP, Brazil.
C3 Universidade Federal do Maranhao; Universidade de Sao Paulo
RP Paes, AMD (corresponding author), Univ Fed Maranhao, Av Portugueses 1966, BR-65080805 Sao Luis, MA, Brazil.
EM marcuspaes@ufma.br
RI Kajihara, Daniela/AAR-1172-2020; França, Lucas/IAM-5986-2023; Laurindo,
   Francisco/J-6575-2015; Paes, Antonio Marcus de Andrade/C-7174-2013
OI Laurindo, Francisco/0000-0001-6837-4509; Kajihara,
   Daniela/0000-0001-9239-4198; Martins Franca, Lucas/0000-0002-4412-1539;
   Paes, Antonio Marcus de Andrade/0000-0002-3803-9803
FU Fundacao de Amparo a Pesquisa e ao Desenvolvimento Cientifico e
   Tecnologico do Maranhao-FAPEMA (Brazil) [PAEDT-02111/15,
   ESTAGIO-05281/15, UNIVERSAL-01475/16, PAEDT-03306/17]; Conselho Nacional
   de Desenvolvimento Cientifico e Tecnologico-CNPq (Brazil); Coordenacao
   de Aperfeicoamento de Pessoal de Nivel Superior-CAPES (Brazil)
FX This work was supported by Fundacao de Amparo a Pesquisa e ao
   Desenvolvimento Cientifico e Tecnologico do Maranhao-FAPEMA (Brazil)
   through the grants PAEDT-02111/15, ESTAGIO-05281/15, UNIVERSAL-01475/16
   and PAEDT-03306/17. P.C.S. and CF.F.C received fellowship from Conselho
   Nacional de Desenvolvimento Cientifico e Tecnologico-CNPq (Brazil).
   C.V.V. received fellowship from Coordenacao de Aperfeicoamento de
   Pessoal de Nivel Superior-CAPES (Brazil).
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NR 76
TC 34
Z9 35
U1 0
U2 9
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0955-2863
EI 1873-4847
J9 J NUTR BIOCHEM
JI J. Nutr. Biochem.
PD DEC
PY 2018
VL 62
BP 155
EP 166
DI 10.1016/j.jnutbio.2018.09.007
PG 12
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA HD6UP
UT WOS:000452684500017
PM 30300835
DA 2025-06-11
ER

PT J
AU Milagro, FI
   Campión, J
   Martínez, JA
AF Milagro, Fermin I.
   Campion, Javier
   Martinez, J. Alfredo
TI Weight gain induced by high-fat feeding involves increased liver
   oxidative stress
SO OBESITY
LA English
DT Article
DE cafeteria diet; inflammation; adipose; gene expression; insulin
   resistance
ID METABOLIC SYNDROME; INSULIN-RESISTANCE; HEPATIC STEATOSIS;
   ADIPOSE-TISSUE; OBESITY; INFLAMMATION; LEPTIN; NASH; DIET; LIPOTOXICITY
AB Objective: To assess the effects of high-fat feeding on white adipose tissue gene expression and liver oxidative stress.
   Research Methods and Procedures: Male Wistar rats were fed on standard pelleted or high-fat diet to produce a diet-induced obesity model. Therefore, body composition, serum biochemical values and liver malondialdehyde (MDA) were determined after 56 days of feeding. Expression (mRNA) values of three genes were also determined by reverse transcriptase-polymerase chain reaction in white adipose tissue.
   Results: Animals fed on the high-fat diet showed more body weight, higher fat deposition and total liver weight, and increased energy intake compared with those on the Standard-fat diet. Serum fasting measurements (glucose, insulin, leptin) and homeostasis model assessment insulin resistance index were significantly increased by the high-fat diet consumption. As an indicator of oxidative stress,. peroxide decomposition in liver was analyzed, showing an increase of MDA concentrations in rats fed on high-fat diet in comparison with control rats. Interestingly, liver MDA levels correlated positively with body weight gain, serum leptin, and homeostasis model assessment. Finally, leptin and glycerol-3-phosphate dehydrogenase mRNA levels, but not fatty acid synthase, were increased by high-fat diet in comparison with the control-fed group.
   Discussion: These results show a link among increased fat depots, insulin resistance, and liver oxidative stress. Thus, liver oxidative stress probably contributes to hepatic disorders and aggravates the metabolic syndrome, which is accompanied by a stimulation of the esterification of fatty acids as measured by glycerol-3-phosphate dehydrogenase in the adipose tissue, providing support to the hypothesis that not only calories count in the induction of weight gain or metabolic syndrome and that other factors such as oxidative stress may be involved.
C1 Univ Navarra, Dept Physiol & Nutr, Pamplona, Spain.
C3 University of Navarra
RP Martínez, JA (corresponding author), Univ Navarra, Dept Physiol & Nutr, C Irunlarrea S-N, Pamplona, Spain.
EM jalfmtz@unav.es
RI Milagro, Fermin/F-2315-2015; Martínez, J./K-8709-2014
OI Milagro, Fermin I./0000-0002-3228-9916; Campion,
   Javier/0000-0002-6522-8271
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NR 29
TC 189
Z9 207
U1 1
U2 35
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1930-7381
EI 1930-739X
J9 OBESITY
JI Obesity
PD JUL
PY 2006
VL 14
IS 7
BP 1118
EP 1123
DI 10.1038/oby.2006.128
PG 6
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 077KP
UT WOS:000240028500003
PM 16899792
OA Bronze
DA 2025-06-11
ER

PT J
AU Barnawi, BM
   Alanazi, MM
   Al-Mutiri, FA
   Alqahtani, RS
   Al-harbi, MS
   Al-Raqqas, SK
   Mahjoub, WK
   Alsetri, MM
   Al-Sultan, ZM
   Alghamdi, GM
   Almutawah, RI
AF Barnawi, Bandar M.
   Alanazi, Maram M.
   Al-Mutiri, Fai A.
   Alqahtani, Rahaf S.
   Al-harbi, Madhawi S.
   Al-Raqqas, Saud K.
   Mahjoub, Waleed K.
   Alsetri, Mahdi M.
   Al-Sultan, Ziyad M.
   Alghamdi, Ghadeer M.
   Almutawah, Ridha I.
TI Interlinked Pathways: Exploring the Bidirectional Impacts of
   Periodontitis and Metabolic Syndrome
SO CUREUS JOURNAL OF MEDICAL SCIENCE
LA English
DT Review
DE cytokines; insulin resistance; inflammation; metabolic syndrome;
   periodontitis
ID INSULIN-RESISTANCE; SYSTEMIC INFLAMMATION; ENDOTHELIAL DYSFUNCTION;
   DIABETES-MELLITUS; OXIDATIVE STRESS; ADIPOSE-TISSUE; ARTERIAL STIFFNESS;
   CONSENSUS REPORT; CYTOKINE LEVELS; ORAL CONDITIONS
AB Metabolic syndrome (MBS) and periodontitis are distinct conditions with overlapping and unique risk factors. Periodontitis is a chronic destructive disease of the periodontium, driven by alterations in the host immune-inflammatory response to virulent periodontal pathogens. MBS is characterized by various abnormalities, including visceral abdominal obesity, dyslipidemia (low high-density lipoprotein (HDL) and high triglyceride (TG) levels), hypertension, and hyperglycemia. These factors collectively increase the risk of atherosclerotic cardiovascular disease (CVD) and diabetes. Several pro-inflammatory mediators are involved in the pathogenesis of periodontitis and MBS, and the deleterious bidirectional effects of these mediators exacerbate the severity and progression of both conditions. This comprehensive review focuses on the intricate relationship between MBS and periodontitis. Specifically, it explores the pathophysiological mechanisms of each disease component of MBS and its impact on periodontitis, and vice versa.
C1 [Barnawi, Bandar M.] Minist Hlth, Family Dent, Medinah, Saudi Arabia.
   [Alanazi, Maram M.; Al-Mutiri, Fai A.; Alqahtani, Rahaf S.; Al-harbi, Madhawi S.] King Saud Bin Abdulaziz Univ Hlth Sci, Coll Dent, Riyadh, Saudi Arabia.
   [Al-Raqqas, Saud K.] King Abdulaziz Med City Riyadh, Dent, Riyadh, Saudi Arabia.
   [Mahjoub, Waleed K.; Alsetri, Mahdi M.; Al-Sultan, Ziyad M.] King Saud Univ, Coll Dent, Riyadh, Saudi Arabia.
   [Alghamdi, Ghadeer M.] Minist Hlth, Dent, Dammam, Saudi Arabia.
   [Almutawah, Ridha I.] King Faisal Univ, Dent, Alhfuf, Saudi Arabia.
C3 King Saud Bin Abdulaziz University for Health Sciences; King Saud Bin
   Abdulaziz University for Health Sciences; King Abdulaziz Medical City -
   Riyadh; King Saud University; Ministry of Health - Saudi Arabia; King
   Faisal University
RP Barnawi, BM (corresponding author), Minist Hlth, Family Dent, Medinah, Saudi Arabia.
EM dr.barnawi@hotmail.com
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NR 135
TC 0
Z9 0
U1 0
U2 2
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
EI 2168-8184
J9 CUREUS J MED SCIENCE
JI Cureus J Med Sci
PD AUG 22
PY 2024
VL 16
IS 8
AR e67544
DI 10.7759/cureus.67544
PG 12
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA D9E1G
UT WOS:001299130300014
PM 39310407
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Brown, KL
   Hines, AL
   Hagiwara, N
   Utsey, S
   Perera, RA
   LaRose, JG
AF Brown, Kristal Lyn
   Hines, Anika L.
   Hagiwara, Nao
   Utsey, Shawn
   Perera, Robert A.
   LaRose, Jessica Gokee
TI The Weight of Racial Discrimination: Examining the Association Between
   Racial Discrimination and Change in Adiposity Among Emerging Adult Women
   Enrolled in a Behavioral Weight Loss Program
SO JOURNAL OF RACIAL AND ETHNIC HEALTH DISPARITIES
LA English
DT Article
DE Racial discrimination; Racism; Health disparities; Emerging adults;
   Women; Obesity
ID AFRICAN-AMERICAN; YOUNG-ADULTS; PERCEIVED DISCRIMINATION; SOCIAL
   SUPPORT; PSYCHOLOGICAL DISTRESS; METABOLIC SYNDROME; LOSS INTERVENTION;
   RISK-FACTORS; STRESS; BLACK
AB Background Non-Hispanic Black (NHB) emerging adult (EA) women are at disproportionate risk for obesity but experience limited benefit from behavioral weight loss (BWL) programs. Race-related stress could play a role; the goal of this study was to examine the association between racial discrimination (RD) and early (3 months) changes in adiposity, and to explore potential protective factors, among EA in an adapted BWL program. Methods This is an ancillary study of non-Hispanic White (NHW) and NHB EA women enrolled in an adapted BWL trial (N = 49; 55.1% NHB; Age 21.2 (2.1); BMI = 33.0 + 4.3 kg/m(2)). At baseline, group- and personal-level RD (RD-group and RD-personal), racial identity (NHB women only), vigilant coping, and social support were assessed via validated questionnaires. Weight and waist circumference were measured objectively at 0 and 3 months. Results NHW women manifested greater reductions in waist circumference relative to NHB women (p = .004). RD-personal did not predict change in waist circumference at 3 months (p = .402); however, the association between RD-group and change in waist circumference was statistically significant (p = .015), such that reporting greater group-level discrimination predicted a smaller decrease in waist circumference; the model explained 22% of the variance. Social support and vigilant coping were not statistically significant in the model. Among NHB women only, higher racial identity-centrality predicted greater reduction in waist circumference (p = .019). Conclusion Findings suggest racial discrimination could contribute to greater cardiometabolic risk during this developmental period. Future research should examine how experiences of racial discrimination unfold in the daily lives of NHB women to inform mechanistic interventions to enhance health and well-being.
C1 [Brown, Kristal Lyn; Hines, Anika L.; LaRose, Jessica Gokee] Virginia Commonwealth Univ, Sch Med, Dept Hlth Behav & Policy, Richmond, VA 23298 USA.
   [Brown, Kristal Lyn] Johns Hopkins Univ, Sch Med, Div Gen Internal Med, Baltimore, MD 21205 USA.
   [Hagiwara, Nao; Utsey, Shawn] Virginia Commonwealth Univ, Dept Psychol, Box 2018, Richmond, VA 23284 USA.
   [Utsey, Shawn] Virginia Commonwealth Univ, Dept African Amer Studies, Richmond, VA USA.
   [Perera, Robert A.] Virginia Commonwealth Univ, Sch Med, Dept Biostat, Richmond, VA USA.
C3 Virginia Commonwealth University; Johns Hopkins University; Virginia
   Commonwealth University; Virginia Commonwealth University; Virginia
   Commonwealth University
RP Brown, KL (corresponding author), Virginia Commonwealth Univ, Sch Med, Dept Hlth Behav & Policy, Richmond, VA 23298 USA.; Brown, KL (corresponding author), Johns Hopkins Univ, Sch Med, Div Gen Internal Med, Baltimore, MD 21205 USA.
EM Kbrow222@jhmi.edu
RI LaRose, Jessica/ABD-1462-2021; Perera, Robert/HNT-0118-2023; Hagiwara,
   Nao/LFV-1374-2024; Hagiwara, Nao/H-3946-2017
OI Hines, Anika/0000-0003-3502-5606; Hagiwara, Nao/0000-0003-3933-8917;
   Brown, Kristal/0000-0003-4633-5677; LaRose, Jessica/0000-0001-6497-4814
FU National Institutes of Diabetes and Digestive and Kidney Diseases
   [R01DK103668]; American Association of University Women (AAUW)
FX This work was supported in part by National Institutes of Diabetes and
   Digestive and Kidney Diseases (R01DK103668) to Jessica G. LaRose.
   Additional support received from the American Association of University
   Women (AAUW). The funders had no role in the design, execution or
   interpretation of this work.
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NR 98
TC 13
Z9 15
U1 0
U2 2
PU SPRINGER INT PUBL AG
PI CHAM
PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND
SN 2197-3792
EI 2196-8837
J9 J RACIAL ETHN HEALTH
JI J. Racial Ethn. Health Disparities
PD JUN
PY 2022
VL 9
IS 3
BP 909
EP 920
DI 10.1007/s40615-021-01030-7
EA MAR 2021
PG 12
WC Public, Environmental & Occupational Health
WE Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA 0X6QX
UT WOS:000634605600001
PM 33782906
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Mohan, J
   Ghazi, T
   Chuturgoon, AA
AF Mohan, Jivanka
   Ghazi, Terisha
   Chuturgoon, Anil A.
TI A Critical Review of the Biochemical Mechanisms and Epigenetic
   Modifications in HIV- and Antiretroviral-Induced Metabolic Syndrome
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE metabolic syndrome; HIV; ARVs; mitochondrial dysfunction; inflammation;
   epigenetics
ID REVERSE-TRANSCRIPTASE INHIBITORS; NECROSIS-FACTOR-ALPHA; PROTEASE
   INHIBITORS; INSULIN-RESISTANCE; MITOCHONDRIAL-DNA; T-CELLS; ADIPOCYTE
   DIFFERENTIATION; NLRP3 INFLAMMASOME; IMMUNE ACTIVATION; VIRUS-INFECTION
AB Metabolic syndrome (MetS) is a non-communicable disease characterised by a cluster of metabolic irregularities. Alarmingly, the prevalence of MetS in people living with Human Immunodeficiency Virus (HIV) and antiretroviral (ARV) usage is increasing rapidly. This study aimed to look at biochemical mechanisms and epigenetic modifications associated with HIV, ARVs, and MetS. More specifically, emphasis was placed on mitochondrial dysfunction, insulin resistance, inflammation, lipodystrophy, and dyslipidaemia. We found that mitochondrial dysfunction was the most common mechanism that induced metabolic complications. Our findings suggest that protease inhibitors (PIs) are more commonly implicated in MetS-related effects than other classes of ARVs. Furthermore, we highlight epigenetic studies linking HIV and ARV usage to MetS and stress the need for more studies, as the current literature remains limited despite the advancement in and popularity of epigenetics.
C1 [Mohan, Jivanka; Ghazi, Terisha; Chuturgoon, Anil A.] Univ KwaZulu Natal, Sch Lab Med & Med Sci, Discipline Med Biochem, ZA-4041 Durban, South Africa.
C3 University of Kwazulu Natal
RP Chuturgoon, AA (corresponding author), Univ KwaZulu Natal, Sch Lab Med & Med Sci, Discipline Med Biochem, ZA-4041 Durban, South Africa.
EM mxtjivee@gmail.com; terishaghazi@gmail.com; chutur@ukzn.ac.za
RI Ghazi, Terisha/AAU-5164-2021; Chuturgoon, Anil/AAE-5068-2021
OI Ghazi, Terisha/0000-0002-0179-213X; Mohan, Jivanka/0000-0001-8446-5099
FU DAAD [128896]; National Research foundation [120820]
FX This research was funded by DAAD (grant number UID: 128896) and The
   National Research foundation (grant number: 120820).
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NR 101
TC 24
Z9 24
U1 0
U2 4
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD NOV
PY 2021
VL 22
IS 21
AR 12020
DI 10.3390/ijms222112020
PG 15
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA WX4RE
UT WOS:000718584100001
PM 34769448
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Yang, M
   Qing, SG
   Xie, GB
   Sheng, GT
   Yang, JQ
AF Yang, Ming
   Qing, Shangguan
   Xie, Guobo
   Sheng, Guotai
   Yang, Jingqi
TI Oxidative stress mediates the association between triglyceride-glucose
   index and risk of cardiovascular and all-cause mortality in metabolic
   syndrome: evidence from a prospective cohort study
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Article
DE triglyceride-glucose index; cardiovascular; all-cause mortality;
   metabolic syndrome; oxidative stress; mediation effect
ID PROVISIONAL REPORT; REACTIVE OXYGEN; URIC-ACID; DISEASE
AB Background: The aim of this study was to investigate the relationship between triglyceride-glucose (TyG) index and cardiovascular disease (CVD) and all-cause mortality in adults with metabolic syndrome (MeS) and explore the mediating role of oxidative stress. Methods: This study included 6131 adults with MeS from the National Health and Nutrition Examination Survey (NHANES). The relationships between TyG index and mortality were elucidated using multivariate Cox proportional hazards models, restricted cubic splines (RCS) Fine-Gray competing risk model. In addition, mediation analysis was used to test the indirect effect of oxidative stress indicators. Results: Over a median 106-month follow-up, a total of 357 CVD and 1292 all-cause deaths were recorded. After multivariate adjustment, there was a J-type relationship between TyG index and CVD and all-cause mortality, with optimal inflection point of 9.13 and 8.92. After the threshold point, TyG index was positively associated with CVD (HR: 4.21, 95%CI: 1.82, 9.78) and all-cause mortality(HR: 2.93, 95%CI: 2.05, 4.18). Even using non-cardiovascular mortality as a competitive risk, the Fine-Gray model also illustrated that the cumulative CVD mortality incidence was higher in MeS with TyG index >9.13 (Fine-Gray P< 0.01). Mediation analysis revealed that biomarkers of oxidative stress, including gamma-glutamyl transferase and uric acid, collectively mediated 10.53% of the association between the TyG index and CVD mortality, and 8.44% of the association with all-cause mortality (P < 0.05). Conclusion: In the cohort study, TyG index was found to have a J-shaped association with CVD mortality and all-cause mortality in MeS population and oxidative stress may play a key mediating role in this relationship.
C1 [Yang, Ming; Qing, Shangguan; Xie, Guobo; Sheng, Guotai; Yang, Jingqi] Nanchang Med Coll, Jiangxi Prov Peoples Hosp, Affiliated Hosp 1, Dept Cardiovasc Med, Nanchang, Jiangxi, Peoples R China.
C3 Nanchang Medical College
RP Yang, JQ (corresponding author), Nanchang Med Coll, Jiangxi Prov Peoples Hosp, Affiliated Hosp 1, Dept Cardiovasc Med, Nanchang, Jiangxi, Peoples R China.
EM yangjingqi2019@126.com
FU Health and Family Planning Commission of Jiangxi Province [202130053]
FX The author(s) declare financial support was received for the research,
   authorship, and/or publication of this article. The authors' research
   was supported by Health and Family Planning Commission of Jiangxi
   Province (Grant Number: 202130053).
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NR 48
TC 9
Z9 10
U1 4
U2 7
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD AUG 20
PY 2024
VL 15
AR 1452896
DI 10.3389/fendo.2024.1452896
PG 13
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA E5W9A
UT WOS:001303716200001
PM 39229375
OA Green Published, gold
DA 2025-06-11
ER

PT J
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AF Ashikawa, Sao
   Komatsu, Yuki
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   Aoyama, Kiyoshi
   Nakano, Shiho
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   Hayakawa, Misaki
   Sakabe, Nanako
   Furukawa, Nozomi
   Ikeda, Katsuhide
   Murohara, Toyoaki
   Nagata, Kohzo
TI Pharmacological inhibition of the lipid phosphatase PTEN ameliorates
   heart damage and adipose tissue inflammation in stressed rats with
   metabolic syndrome
SO PHYSIOLOGICAL REPORTS
LA English
DT Article
DE adipose tissue inflammation; cardiac injury; metabolic syndrome; PTEN;
   regulatory B cell; stress
ID ATTENUATES CARDIAC-HYPERTROPHY; ENDOTHELIAL GROWTH-FACTOR;
   DAHLS.Z-LEPR(FA)/LEPR(FA) RATS; DIASTOLIC DYSFUNCTION; ANIMAL-MODEL;
   B-CELLS; OBESITY; ANGIOGENESIS; ACTIVATION; HYPERTENSION
AB Phosphatidylinositol 3-kinase (PI3K) signaling promotes the differentiation and proliferation of regulatory B (Breg) cells, and the lipid phosphatase phosphatase and tensin homolog deleted on chromosome 10 (PTEN) antagonizes the PI3K-Akt signaling pathway. We previously demonstrated that cardiac Akt activity is increased and that restraint stress exacerbates hypertension and both heart and adipose tissue (AT) inflammation in DS/obese rats, an animal model of metabolic syndrome (MetS). We here examined the effects of restraint stress and pharmacological inhibition of PTEN on heart and AT pathology in such rats. Nine-week-old animals were treated with the PTEN inhibitor bisperoxovanadium-pic [bpV(pic)] or vehicle in the absence or presence of restraint stress for 4 weeks. BpV(pic) treatment had no effect on body weight or fat mass but attenuated hypertension in DS/obese rats subjected to restraint stress. BpV(pic) ameliorated left ventricular (LV) inflammation, fibrosis, and diastolic dysfunction as well as AT inflammation in the stressed rats. Restraint stress reduced myocardial capillary density, and this effect was prevented by bpV(pic). In addition, bpV(pic) increased the proportions of Breg and B-1 cells as well as reduced those of CD8(+) T and B-2 cells in AT of stressed rats. Our results indicate that inhibition of PTEN by bpV(pic) alleviated heart and AT inflammation in stressed rats with MetS. These positive effects of bpV(pic) are likely due, at least in part, to a reduction in blood pressure, an increase in myocardial capillary formation, and an altered distribution of immune cells in fat tissue that result from the activation of PI3K-Akt signaling.
C1 [Ashikawa, Sao; Komatsu, Yuki; Kawai, Yumeno; Aoyama, Kiyoshi; Nakano, Shiho; Cui, Xixi; Hayakawa, Misaki; Sakabe, Nanako; Furukawa, Nozomi; Ikeda, Katsuhide; Nagata, Kohzo] Dept Integrated Hlth Sci, Pathophysiol Sci, Nagoya, Aichi, Japan.
   [Murohara, Toyoaki] Nagoya Univ, Dept Cardiol, Grad Sch Med, Nagoya, Aichi, Japan.
C3 Nagoya University
RP Nagata, K (corresponding author), Nagoya Univ, Dept Integrated Hlth Sci, Grad Sch Med, Pathophysiol Sci,Higashi Ku, 1-1-20 Daikominami, Nagoya, Aichi 4618673, Japan.
EM nagata@met.nagoya-u.ac.jp
RI Ikeda, Katsuhide/GWZ-6640-2022
FU MEXT [17K15614]; Grants-in-Aid for Scientific Research [21K17639,
   17K15614] Funding Source: KAKEN
FX This work was supported by grant 17K15614 from MEXT to A. Uchinaka as
   well as by personal funds from Osamu Yoshida and Kohzo Nagata to K.
   Nagata.
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NR 50
TC 2
Z9 2
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2051-817X
J9 PHYSIOL REP
JI PHYSIOL. REP.
PD JAN
PY 2022
VL 10
IS 1
AR e15165
DI 10.14814/phy2.15165
PG 15
WC Physiology
WE Emerging Sources Citation Index (ESCI)
SC Physiology
GA YL0ZU
UT WOS:000745630300010
PM 35005845
OA Green Published
DA 2025-06-11
ER

PT J
AU Skalicky, J
   Muzakova, V
   Kandar, R
   Meloun, M
   Rousar, T
AF Skalicky, J.
   Muzakova, V
   Kandar, R.
   Meloun, M.
   Rousar, T.
TI Oxidative stress and metabolic syndrome in obese adults with and without
   controlled diet restriction
SO BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY
LA English
DT Article
DE oxidative stress; metabolic syndrome; obesity; energy intake restriction
ID WEIGHT-LOSS; CARDIOVASCULAR MORBIDITY; RISK-FACTORS; URIC-ACID;
   MORTALITY; INSULIN; CARBOHYDRATE; INFLAMMATION; LEUKOCYTES; DISEASE
AB Background. Metabolic syndrome (MetS) represents a collection of markers associated with cardiovascular morbidity and mortality. Due to its high prevalence and steady increase of the occurrence, prevention or management of MetS is of paramount importance. The aim of our study was to evaluate MetS occurrence and extent of oxidative stress by comparing obese adults after diet optimization with untreated controls.
   Material and methods: Oxidative stress markers (total amount of free radicals, malondialdehyde, allantoin, alpha 1-antiproteinase, GSSG/GSH ratio), total antioxidant capacity and lipid standardized (x-tocopherol were determined in 40 obese people and 48 healthy controls. The obese people were divided into two group A: obese with restricted energy intake with lowered dietary carbohydrates (n=20) and group 13: with the same grade of obesity but without following dietary recommendations (n=20).
   Results: Group A exhibited lower oxidative stress markers than group B; free radicals (5.18 +/- 1.68 vs 8.43 +/- 3.66 mmol/l, p<0.01), GSSG/GSH ratio (11.74 +/- 5.01 vs 15.38 +/- 5.93 %, p<0.05) and higher antioxidants: lipid standardized a-tocopherol (3.70 +/- 0.51 vs 3.35 +/- 0.60, p<0.05) and ceruloplasmin (0.24 +/- 0.08 vs 0.21 +/- 0.03 g/l, p<0.05), in the course of same grade of obesity. Furthermore MetS occurrence was found significantly lower was in group A.
   Conclusion: The energy intake restriction by 2000 kJ, mainly due to carbohydrate limitations, was associated with decreased oxidative stress and simultaneously increased lipid-standardized a-tocopherol and ceruloplasmin in obese people. These changes correlated with diminished MetS occurrence by about 50 % (Tab. 3, Ref. 32). Full Text (Free, PDF) www.bmj.sk.
C1 [Skalicky, J.] Reg Hosp Pardubice, Dept Clin Biochem & Diagnost, Pardubice, Czech Republic.
   [Muzakova, V; Kandar, R.; Rousar, T.] Univ Pardubice, Dept Biol & Biochem Sci, Fac Chem Technol, CZ-53203 Pardubice, Czech Republic.
   [Meloun, M.] Univ Pardubice, Dept Analyt Chem, Fac Chem Technol, CZ-53203 Pardubice, Czech Republic.
C3 University of Pardubice; University of Pardubice
RP Muzakova, V (corresponding author), Univ Pardubice, Dept Biol & Biochem Sci, Fac Chem Technol, Strossova 239, CZ-53203 Pardubice, Czech Republic.
EM skalicky@nem.pce.cz
RI Rousar, Tomas/AAV-6341-2021
OI Rousar, Tomas/0000-0002-6893-821X
CR Ahuja KDK, 2006, NUTRITION, V22, P259, DOI 10.1016/j.nut.2005.07.015
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NR 32
TC 9
Z9 12
U1 0
U2 7
PU COMENIUS UNIV
PI BRATISLAVA I
PA SCH MEDICINE, SPITALSKA 24, BRATISLAVA I, SK-813 72, SLOVAKIA
SN 0006-9248
EI 1336-0345
J9 BRATISL MED J
JI Bratisl. Med. J.
PY 2009
VL 110
IS 3
BP 152
EP 157
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 440AH
UT WOS:000265669500005
PM 19507634
DA 2025-06-11
ER

PT J
AU Fatima, S
   Hu, XJ
   Gong, RH
   Huang, CH
   Chen, MT
   Wong, HLX
   Bian, ZX
   Kwan, HY
AF Fatima, Sarwat
   Hu, Xianjing
   Gong, Rui-Hong
   Huang, Chunhua
   Chen, Minting
   Wong, Hoi Leong Xavier
   Bian, Zhaoxiang
   Kwan, Hiu Yee
TI Palmitic acid is an intracellular signaling molecule involved in disease
   development
SO CELLULAR AND MOLECULAR LIFE SCIENCES
LA English
DT Review
DE Palmitic acid; Metabolic syndrome; Cardiovascular diseases; Cancer;
   Neurodegenerative diseases; Inflammation
ID ENDOPLASMIC-RETICULUM STRESS; SATURATED FATTY-ACIDS;
   CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; ADIPOSE-TISSUE;
   INSULIN-RESISTANCE; TRANSCRIPTIONAL REGULATION; MITOCHONDRIAL DAMAGE;
   LEPTIN RESISTANCE; ADIPOCYTE DEATH
AB Emerging evidence shows that palmitic acid (PA), a common fatty acid in the human diet, serves as a signaling molecule regulating the progression and development of many diseases at the molecular level. In this review, we focus on its regulatory roles in the development of five pathological conditions, namely, metabolic syndrome, cardiovascular diseases, cancer, neurodegenerative diseases, and inflammation. We summarize the clinical and epidemiological studies; and also the mechanistic studies which have identified the molecular targets for PA in these pathological conditions. Activation or inactivation of these molecular targets by PA controls disease development. Therefore, identifying the specific targets and signaling pathways that are regulated by PA can give us a better understanding of how these diseases develop for the design of effective targeted therapeutics.
C1 [Fatima, Sarwat; Hu, Xianjing; Gong, Rui-Hong; Huang, Chunhua; Chen, Minting; Wong, Hoi Leong Xavier; Bian, Zhaoxiang; Kwan, Hiu Yee] Hong Kong Baptist Univ, Sch Chinese Med, Ctr Clin Res Chinese Med, Hong Kong, Peoples R China.
   [Fatima, Sarwat; Hu, Xianjing; Gong, Rui-Hong; Huang, Chunhua; Chen, Minting; Wong, Hoi Leong Xavier; Bian, Zhaoxiang; Kwan, Hiu Yee] Hong Kong Baptist Univ, Ctr Canc & Inflammat Res, Hong Kong, Peoples R China.
C3 Hong Kong Baptist University; Hong Kong Baptist University
RP Bian, ZX; Kwan, HY (corresponding author), Hong Kong Baptist Univ, Sch Chinese Med, Ctr Clin Res Chinese Med, Hong Kong, Peoples R China.; Bian, ZX; Kwan, HY (corresponding author), Hong Kong Baptist Univ, Ctr Canc & Inflammat Res, Hong Kong, Peoples R China.
EM bzxiang@hkbu.edu.hk; hykwan@hkbu.edu.hk
RI Wong, Hoi/P-1293-2019; GONG, RUIHONG/IXD-9536-2023
OI Gong, Ruihong/0000-0002-4555-0394; Wong, Hoi Leong
   Xavier/0000-0002-2460-4808; KWAN, Hiu Yee/0000-0002-6088-7323
FU Research Grant Council of HKSAR [HKBU-22103017-ECS]; Natural Science
   Foundation of Guangdong Province [2018A0303130122]; Hong Kong Baptist
   University [FRG2/16-17/010, FRG2/17-18/002]
FX This work was partially supported by the Research Grant Council of HKSAR
   HKBU-22103017-ECS, Natural Science Foundation of Guangdong Province
   #2018A0303130122, and the Hong Kong Baptist University Grant
   FRG2/16-17/010 and FRG2/17-18/002.
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NR 127
TC 105
Z9 116
U1 2
U2 52
PU SPRINGER BASEL AG
PI BASEL
PA PICASSOPLATZ 4, BASEL, 4052, SWITZERLAND
SN 1420-682X
EI 1420-9071
J9 CELL MOL LIFE SCI
JI Cell. Mol. Life Sci.
PD JUL
PY 2019
VL 76
IS 13
BP 2547
EP 2557
DI 10.1007/s00018-019-03092-7
PG 11
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA IE6JT
UT WOS:000472483200007
PM 30968170
OA Green Published
DA 2025-06-11
ER

PT J
AU Maes, M
   Vasupanrajit, A
   Jirakran, K
   Klomkliew, P
   Chanchaem, P
   Tunvirachaisakul, C
   Plaimas, K
   Suratanee, A
   Payungporn, S
AF Maes, Michael
   Vasupanrajit, Asara
   Jirakran, Ketsupar
   Klomkliew, Pavit
   Chanchaem, Prangwalai
   Tunvirachaisakul, Chavit
   Plaimas, Kitiporn
   Suratanee, Apichat
   Payungporn, Sunchai
TI Adverse childhood experiences and reoccurrence of illness impact the gut
   microbiome, which affects suicidal behaviours and the phenome of major
   depression: towards enterotypic phenotypes
SO ACTA NEUROPSYCHIATRICA
LA English
DT Article
DE major depression; bacterial translocation; gut-brain axis; neuro-immune;
   inflammation; oxidative and nitrosative stress
ID ENTEROBACTERIA LEAKY GUT; BACTERIAL TRANSLOCATION; GEN. NOV.; METABOLIC
   SYNDROME; RATING-SCALE; INFLAMMATION; ASSOCIATION; SUCCINATE; SEVERITY;
   TOXICITY
AB The first publication demonstrating that major depressive disorder (MDD) is associated with alterations in the gut microbiota appeared in 2008 (Maes et al., 2008). The purpose of the present study is to delineate a) the microbiome signature of the phenome of depression, including suicidal behaviours (SB) and cognitive deficits; the effects of adverse childhood experiences (ACEs) and recurrence of illness index (ROI) on the microbiome; and the microbiome signature of lowered high-density lipoprotein cholesterol (HDLc). We determined isometric log-ratio abundances or prevalences of gut microbiome phyla, genera, and species by analysing stool samples from 37 healthy Thai controls and 32 MDD patients using 16S rDNA sequencing. Six microbiome taxa accounted for 36% of the variance in the depression phenome, namely Hungatella and Fusicatenibacter (positive associations) and Butyricicoccus, Clostridium, Parabacteroides merdae, and Desulfovibrio piger (inverse association). This profile (labelled enterotype 1) indicates compositional dysbiosis, is strongly predicted by ACE and ROI, and is linked to SB. A second enterotype was developed that predicted a decrease in HDLc and an increase in the atherogenic index of plasma (Bifidobacterium, P. merdae, and Romboutsia were positively associated, while Proteobacteria and Clostridium sensu stricto were negatively associated). Together, enterotypes 1 and 2 explained 40.4% of the variance in the depression phenome, and enterotype 1 in conjunction with HDLc explained 39.9% of the variance in current SB. In conclusion, the microimmuneoxysome is a potential new drug target for the treatment of severe depression and SB and possibly for the prevention of future episodes.
C1 [Maes, Michael; Vasupanrajit, Asara; Jirakran, Ketsupar; Tunvirachaisakul, Chavit] Chulalongkorn Univ, Fac Med, Dept Psychiat, Bangkok, Thailand.
   [Maes, Michael; Vasupanrajit, Asara; Jirakran, Ketsupar; Tunvirachaisakul, Chavit] King Chulalongkorn Mem Hosp, Thai Red Cross Soc, Bangkok, Thailand.
   [Maes, Michael] Kyung Hee Univ, 26 Kyungheedae Ro, Seoul, South Korea.
   [Maes, Michael] Med Univ Plovdiv, Dept Psychiat, Plovdiv, Bulgaria.
   [Maes, Michael] Barwon Hlth, IMPACT Strateg Res Ctr, Geelong, Australia.
   [Jirakran, Ketsupar] Chulalongkorn Univ, Fac Med, Dept Pediat, Maximizing Thai Childrens Dev Potential Res Unit, Bangkok, Thailand.
   [Klomkliew, Pavit; Chanchaem, Prangwalai; Payungporn, Sunchai] Chulalongkorn Univ, Fac Med, Ctr Excellence Syst Microbiol, Dept Biochem, Bangkok, Thailand.
   [Plaimas, Kitiporn] Chulalongkorn Univ, Fac Sci, Adv Virtual & Intelligent Comp AVIC Ctr, Dept Math & Comp Sci, Bangkok 10330, Thailand.
   [Suratanee, Apichat] King Mongkuts Univ Technol North Bangkok, Fac Appl Sci, Dept Math, Bangkok 10800, Thailand.
C3 Chulalongkorn University; Chulalongkorn University; Thai Red Cross
   Society; Kyung Hee University; Medical University Plovdiv; Barwon
   Health; Chulalongkorn University; Chulalongkorn University;
   Chulalongkorn University; King Mongkuts University of Technology North
   Bangkok
RP Maes, M (corresponding author), Chulalongkorn Univ, Fac Med, Dept Psychiat, Bangkok, Thailand.; Maes, M (corresponding author), King Chulalongkorn Mem Hosp, Thai Red Cross Soc, Bangkok, Thailand.; Maes, M (corresponding author), Kyung Hee Univ, 26 Kyungheedae Ro, Seoul, South Korea.; Maes, M (corresponding author), Med Univ Plovdiv, Dept Psychiat, Plovdiv, Bulgaria.; Maes, M (corresponding author), Barwon Hlth, IMPACT Strateg Res Ctr, Geelong, Australia.
EM Dr.michaelmaes@hotmail.com
RI Vasupanrajit, Asara/ABG-5437-2021; Plaimas, Kitiporn/MSY-2654-2025;
   Suratanee, Apichat/ABG-1636-2021; Maes, Michael/B-8546-2011
OI Payungporn, Sunchai/0000-0003-2668-110X; Klomkliew,
   Pavit/0009-0008-8383-9536; Maes, Michael/0000-0002-2012-871X;
   Vasupanrajit, Asara/0000-0002-3716-5621
FU Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
FX This research was supported by a Rachadabhisek Research Grant, Faculty
   of Medicine, Chulalongkorn University, Bangkok, Thailand, to MM. The
   sponsor had no role in the data or manuscript preparation.
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NR 114
TC 26
Z9 26
U1 8
U2 17
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0924-2708
EI 1601-5215
J9 ACTA NEUROPSYCHIATR
JI Acta Neuropsychiatr.
PD DEC
PY 2023
VL 35
IS 6
BP 328
EP 345
DI 10.1017/neu.2023.21
EA APR 2023
PG 18
WC Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Psychiatry
GA HB2E4
UT WOS:000978073000001
PM 37052305
OA hybrid
DA 2025-06-11
ER

PT J
AU Yeh, WC
   Chuang, HH
   Lu, MC
   Tzeng, IS
   Chen, JY
AF Yeh, Wei-Chung
   Chuang, Hai-Hua
   Lu, Mei-Chun
   Tzeng, I-Shiang
   Chen, Jau-Yuan
TI Prevalence of metabolic syndrome among employees of a taiwanese hospital
   varies according to profession
SO MEDICINE
LA English
DT Article
DE health promotion; hospital employees; metabolic syndrome; physicians
ID TYPE-2 DIABETES-MELLITUS; CORONARY-HEART-DISEASE;
   CARDIOVASCULAR-DISEASE; INSULIN-RESISTANCE; US POPULATION; WORK STRESS;
   RISK; OBESITY; PHYSICIANS; GENDER
AB This study aimed to explore the prevalence of metabolic syndrome (MS) among various employee groups at a Taiwan hospital.
   We retrospectively compared the prevalence of MS, as defined by the Taiwan Department of Health, among employee groups (physicians, nurses, medical technicians, and administrative staff) at a medical center in northern Taiwan in 2011. Total cholesterol was used in lieu of high-density lipoprotein cholesterol values.
   The overall prevalence of MS among the 1673 men and 5117 women investigated was 12.0%. Physicians had the highest prevalence of MS (18.3%). Abdominal obesity and high blood sugar were the most (29.3%) and least (10.5%) prevalent abnormalities, respectively.
   The hospital employees had a moderate prevalence of MS. Physicians and administrative staff members had higher prevalence of MS than the other populations.
C1 [Yeh, Wei-Chung; Chen, Jau-Yuan] Chang Gung Mem Hosp, Dept Family Med, Linkou Branch, 5 Fuxing St, Taoyuan 333, Taiwan.
   [Yeh, Wei-Chung; Chen, Jau-Yuan] Chang Gung Univ, Coll Med, Taoyuan, Taiwan.
   [Chuang, Hai-Hua] Chang Gung Mem Hosp, Dept Family Med, Taipei Branch, Taipei, Taiwan.
   [Lu, Mei-Chun] Chang Gung Mem Hosp, Dept Family Med, Taoyuan Branch, Taoyuan, Taiwan.
   [Tzeng, I-Shiang] Taipei Tzu Chi Hosp, Buddhist Tzu Chi Med Fdn, Dept Res, New Taipei, Taiwan.
C3 Chang Gung Memorial Hospital; Chang Gung University; Chang Gung Memorial
   Hospital; Chang Gung Memorial Hospital; Buddhist Tzu Chi General
   Hospital; Taipei Tzu Chi Hospital
RP Chen, JY (corresponding author), Chang Gung Mem Hosp, Dept Family Med, Linkou Branch, 5 Fuxing St, Taoyuan 333, Taiwan.
EM welins@cgmh.org.tw
RI Tzeng, I-Shiang/AAD-8063-2019; Chen, Hsing-yu/C-3979-2011; ,
   Hai-Hua/A-5144-2015
OI , Hai-Hua/0000-0002-7394-4016; Tzeng, I-Shiang/0000-0002-9047-8141
FU Chang Gung Memorial Hospital [CORPG3D0031, CORPG3D0032, CORPG3C0013]
FX This work was supported by Chang Gung Memorial Hospital (CORPG3D0031,
   CORPG3D0032, and CORPG3C0013).
CR [Anonymous], J MED ED
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NR 49
TC 25
Z9 25
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD AUG
PY 2018
VL 97
IS 31
AR e11664
DI 10.1097/MD.0000000000011664
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA GR1AS
UT WOS:000442259200066
PM 30075556
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Belin, RJ
   He, K
AF Belin, Rashad J.
   He, Ka
TI Magnesium physiology and pathogenic mechanisms that contribute to the
   development of the metabolic syndrome
SO MAGNESIUM RESEARCH
LA English
DT Review
DE metabolic syndrome; magnesium; insulin resistance
ID C-REACTIVE PROTEIN; TUMOR-NECROSIS-FACTOR; SMOOTH-MUSCLE-CELLS;
   SPONTANEOUSLY HYPERTENSIVE-RATS; INTRACELLULAR FREE MAGNESIUM;
   ISCHEMIC-HEART-DISEASE; PLASMINOGEN-ACTIVATOR INHIBITOR-1;
   TRIGLYCERIDE-RICH LIPOPROTEINS; DEPENDENT DIABETES-MELLITUS; ACUTE
   MYOCARDIAL-INFARCTION
AB The clinical and public health impact of the metabolic syndrome (MetS) has increased substantially in recent years. MetS is defined by a constellation of cardiovascular disease risk factors including: insulin resistance, elevated blood pressure, impaired glucose tolerance, central obesity, and atherogenic dyslipidemia as well as impaired clotting, increased inflammatory burden, and oxidative stress. Recently, there has been burgeoning experimental, clinical, and epidemiological data that provides strong evidence that dietary magnesium intake and supplementation are inversely associated with the risk for MetS and its components. In this review, we describe and discuss the myriad of integrated physiological mechanisms through which magnesium deficiency and the resultant altered magnesium status may lead to the development of the MetS and each of its components.
C1 Northwestern Univ, Dept Prevent Med, Feinberg Sch Med, Chicago, IL 60611 USA.
   Univ N Carolina, Sch Publ Hlth, Dept Nutr, Chapel Hill, NC 27515 USA.
   Univ N Carolina, Sch Med, Sch Med, Chapel Hill, NC 27515 USA.
C3 Northwestern University; Feinberg School of Medicine; University of
   North Carolina; University of North Carolina Chapel Hill; University of
   North Carolina; University of North Carolina Chapel Hill; University of
   North Carolina School of Medicine
RP Belin, RJ (corresponding author), Northwestern Univ, Dept Prevent Med, Feinberg Sch Med, 680 N Lake Shore Dr,Suite 1102, Chicago, IL 60611 USA.
EM rashad@northwestern.edu
FU NHLBI NIH HHS [T32 HL069771] Funding Source: Medline
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NR 325
TC 86
Z9 92
U1 0
U2 12
PU JOHN LIBBEY EUROTEXT LTD
PI MONTROUGE
PA 127 AVE DE LA REPUBLIQUE, 92120 MONTROUGE, FRANCE
SN 0953-1424
EI 1952-4021
J9 MAGNESIUM RES
JI Magnes. Res.
PD JUN
PY 2007
VL 20
IS 2
BP 107
EP 129
PG 23
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 192HD
UT WOS:000248190600003
PM 18062585
DA 2025-06-11
ER

PT J
AU Violanti, JM
   Fekedulegn, D
   Mnatsakanova, A
   Gu, JK
   Service, S
   Allison, P
   Hartley, TA
AF Violanti, John M.
   Fekedulegn, Desta
   Mnatsakanova, Anna
   Gu, Ja K.
   Service, Samantha
   Allison, Penelope
   Hartley, Tara A.
TI Metabolic Syndrome and Associated Components Among Police Officers
SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
LA English
DT Article
DE police; metabolic syndrome; cardiovascular disease; sex; longitudinal
   analysis
ID CARDIOVASCULAR RISK-FACTORS; POSTTRAUMATIC STRESS; PHYSICAL-ACTIVITY;
   DISEASE RISK; MORTALITY; PREVALENCE; COHORT; WORK; REACTIVITY; SYMPTOMS
AB ObjectiveThis study estimated risk of metabolic syndrome (MetSyn) and its components among police officers including differences by sex.MethodsPolice officers were examined at baseline and two follow-up examinations after 7 and 12 years. MetSyn was defined using the 2005 guidelines from the American Heart Association/National Heart, Lung, and Blood Institute. Risk for incident MetSyn and its components at follow-up exams and risk ratios in males compared to females were estimated using modified Poisson regression.ResultsThe 7- (n = 276) and 12- (n = 191) year incidence of MetSyn was 20.4% and 22.2%, respectively. MetSyn components with lowest and highest incidence were reduced HDL cholesterol and abdominal obesity. The 7-year risk of developing glucose intolerance was two-fold higher in males compared to females.ConclusionsLongitudinal analysis of incidence of MetSyn and its components is important for understanding future cardiovascular disease morbidity and mortality.
C1 [Violanti, John M.] SUNY Buffalo, Sch Publ Hlth & Hlth Profess, Dept Epidemiol & Environm Hlth, Buffalo, NY 14260 USA.
   [Fekedulegn, Desta; Mnatsakanova, Anna; Gu, Ja K.; Service, Samantha; Allison, Penelope] Ctr Dis Control & Prevent, Natl Inst Occupat Safety & Hlth, Hlth Effects Lab Div, Morgantown, WV USA.
   [Hartley, Tara A.] Ctr Dis Control & Prevent, Natl Inst Occupat Safety & Hlth, Off Director, Morgantown, WV USA.
C3 State University of New York (SUNY) System; University at Buffalo, SUNY;
   Centers for Disease Control & Prevention - USA; National Institute for
   Occupational Safety & Health (NIOSH); Centers for Disease Control &
   Prevention - USA; National Institute for Occupational Safety & Health
   (NIOSH)
RP Violanti, JM (corresponding author), SUNY Buffalo, Sch Publ Hlth & Hlth Profess, Dept Epidemiol & Environm Hlth, Buffalo, NY 14260 USA.
EM violanti@buffalo.edu; djf7@cdc.gov; fma8@cdc.gov; gum4@cdc.gov;
   ppf3@cdc.gov; goz2@cdc.gov; tow9@cdc.gov
FU National Institute for Occupational Safety and Health (NIOSH)
   [200-2003-01580, 1R01OH 009640-01A1, 1R01OH010807-01]
FX This work was supported by the National Institute for Occupational
   Safety and Health (NIOSH), contract no. 200-2003-01580 and numbers
   1R01OH 009640-01A1 and 1R01OH010807-01.
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NR 54
TC 0
Z9 0
U1 0
U2 0
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1076-2752
EI 1536-5948
J9 J OCCUP ENVIRON MED
JI J. Occup. Environ. Med.
PD APR
PY 2025
VL 67
IS 4
BP 285
EP 292
DI 10.1097/JOM.0000000000003316
PG 8
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA 1CJ5O
UT WOS:001461673700009
PM 39875317
DA 2025-06-11
ER

PT J
AU Martins, AD
   Majzoub, A
   Agawal, A
AF Martins, Ana Dias
   Majzoub, Ahmad
   Agawal, Ashok
TI Metabolic Syndrome and Male Fertility
SO WORLD JOURNAL OF MENS HEALTH
LA English
DT Review
DE Dyslipidemias; Glucose intolerance; Hypertension; Infertility; male;
   Metabolic syndrome; Obesity
ID BODY-MASS INDEX; DIABETES-MELLITUS; ERECTILE DYSFUNCTION; OXIDATIVE
   STRESS; SEMEN QUALITY; REPRODUCTIVE HORMONES; TESTOSTERONE LEVELS;
   SEXUAL DYSFUNCTION; INSULIN-RESISTANCE; PROVISIONAL REPORT
AB Metabolic syndrome (MetS) represents a cluster of conditions that have a negative impact on human health overall. Its prevalence has been rapidly increasing worldwide and has coincided with a global decrease in birth rates and fertility potential. This review aims to address this observation through studying the relationship between MetS and male reproductive health. The effects of obesity, dyslipidemia, hypertension, and insulin resistance on male fertility were examined and supporting evidence explaining the pathophysiology of sperm dysfunction with each MetS component were described. Adopting a healthy lifestyle appears to be the single most important intervention to prevent the unwanted effects of MetS on men's health and fertility. Further studies addressing the components of MetS and their impact on male reproduction are required to enhance our understanding of the underlying pathophysiology and to propose new methods for therapeutic intervention.
C1 [Martins, Ana Dias; Agawal, Ashok] Cleveland Clin, Amer Ctr Reprod Med, Dept Urol, 10681 Carnegie Ave, Cleveland, OH 44195 USA.
   [Martins, Ana Dias] Univ Porto, Dept Microscopy, Lab Cell Biol, Abel Salazar Inst Biomed Sci ICBAS, Porto, Portugal.
   [Martins, Ana Dias] Univ Porto, Unit Multidisciplinary Res Biomed, Abel Salazar Inst Biomed Sci ICBAS, Porto, Portugal.
   [Majzoub, Ahmad] Hamad Med Corp, Dept Urol, Doha, Qatar.
   [Majzoub, Ahmad] Weill Cornell Med Qatar, Doha, Qatar.
C3 Cleveland Clinic Foundation; Universidade do Porto; Universidade do
   Porto; Hamad Medical Corporation; Qatar Foundation (QF); Weill Cornell
   Medical College Qatar
RP Agawal, A (corresponding author), Cleveland Clin, Amer Ctr Reprod Med, Dept Urol, 10681 Carnegie Ave, Cleveland, OH 44195 USA.
EM agarwaa@ccf.org
RI Martins, Ana/AAR-9647-2020; Majzoub, Ahmad/T-1071-2019
OI Majzoub, Ahmad/0000-0001-7423-6241; Martins, Ana D/0000-0002-7261-9596
FU American Center for Reproductive Medicine; Fundacao para a Ciencia e
   Tecnologia [SFRH/BD/108726/2015]; Fulbright [E0585654]; Fundação para a
   Ciência e a Tecnologia [SFRH/BD/108726/2015] Funding Source: FCT
FX This study was supported by American Center for Reproductive Medicine.
   Ana Dias Martins was funded by the "Fundacao para a Ciencia e
   Tecnologia" (SFRH/BD/108726/2015) and Fulbright (ID: E0585654).
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NR 105
TC 75
Z9 80
U1 0
U2 7
PU KOREAN SOC SEXUAL MEDICINE & ANDROLOGY
PI GWANGJU
PA DEPT UROLOGY, CHONNAM NATL UNIV MEDICAL SCH, 671 JEBONG-RO, DONG-GU,
   GWANGJU, 501-757, SOUTH KOREA
SN 2287-4208
EI 2287-4690
J9 WORLD J MENS HEALTH
JI World J. Mens Health
PD MAY
PY 2019
VL 37
IS 2
BP 113
EP 127
DI 10.5534/wjmh.180055
PG 15
WC Andrology; Health Care Sciences & Services; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Health Care Sciences & Services; Urology &
   Nephrology
GA HU7PV
UT WOS:000465475300001
PM 30350486
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Bourebaba, L
   Kornicka-Garbowska, K
   Al Naem, M
   Röcken, M
   Lyczko, J
   Marycz, K
AF Bourebaba, Lynda
   Kornicka-Garbowska, Katarzyna
   Al Naem, Mohamad
   Rocken, Michael
   Lyczko, Jacek
   Marycz, Krzysztof
TI MSI-1436 improves EMS adipose derived progenitor stem cells in the
   course of adipogenic differentiation through modulation of ER stress,
   apoptosis, and oxidative stress
SO STEM CELL RESEARCH & THERAPY
LA English
DT Article
DE Adipogenesis; Equine metabolic syndrome; Insulin resistance;
   Trodusquemine
ID TYROSINE-PHOSPHATASE 1B; ENDOPLASMIC-RETICULUM STRESS; METABOLIC
   SYNDROME; PPAR-GAMMA; FATTY-ACID; TNF-ALPHA; EQUINE; TISSUE;
   INFLAMMATION; EXPRESSION
AB BackgroundProtein tyrosine phosphatase 1B (PTP1B) is one of the major negative regulators of leptin and insulin signaling, and has been strongly implicated in insulin resistance development in the course of obesity and metabolic syndrome conditions; however, its exact role in controlling adipose tissue biogenesis is still poorly understood.ObjectivesThis investigation aimed to elucidate whether selective inhibition of PTP1B using MSI-1436 compound may improve and restore the defective adipogenicity of ASCs isolated from EMS-affected horses.MethodsEquine ASC EMS cells were cultured under adipogenic conditions in the presence of PTP1B inhibitor and were subsequently tested for expression of the main adipogenic-related genes using RT-qPCR, changes in free fatty acid profiles by means of GC-MS technique, and for mitochondrial dynamics improvement through the analysis of mitochondrial transmembrane potential and oxidative stress.ResultsSelective inhibition of PTP1B in equine ASC EMS cells improved substantially adipogenic differentiation by promoting cellular proliferation and normalizing expression of C/EBPalpha, PPAR gamma, and Adipoq markers that are critical for proper adipogenesis. Levels of secreted adiponectin and PPAR gamma were also shown to be increased in MSI-1436-conditioned cells, while total leptin levels markedly dropped under the same conditions. Moreover, MSI-1436 treatment enabled the regulation of metabolic-related transcripts that are crosslink to adipogenesis, namely Akt1, Akt2, and SHBG. The obtained results demonstrated also an obvious reduction in intracellular accumulated ROS and NO, as well as mitigated ER stress through the downregulation of Chop, Perk, Atf6, Ire1, and Xbp1 transcripts upon PTP1B inhibition. Furthermore, general fluctuations in FFA composition of all differentiated groups have been highlighted, where palmitic acid, palmitoleic acid, stearic acid, and linolelaidic acid that are known to be associated with the development of metabolic disorders were found to be normalized upon PTP1B inhibition during adipogenic differentiation.ConclusionThe presented data provides the evidence that the use of PTP1B inhibitor may be successful in controlling and enhancing adipogenic differentiation of impaired equine ASCs affected by metabolic syndrome, and thus offers new insights for the management of obesity through the regulation of adipose tissue dynamics.
C1 [Bourebaba, Lynda; Kornicka-Garbowska, Katarzyna; Marycz, Krzysztof] Wroclaw Univ Environm & Life Sci, Dept Expt Biol, Norwida 27B St,A7 Bldg, PL-50375 Wroclaw, Poland.
   [Bourebaba, Lynda; Kornicka-Garbowska, Katarzyna; Marycz, Krzysztof] Int Inst Translat Med, Jesionowa 11, PL-55114 Malin, Wisznia Mala, Poland.
   [Al Naem, Mohamad; Rocken, Michael; Marycz, Krzysztof] Justus Liebig Univ, Fac Vet Med, Equine Clin, Equine Surg, D-35392 Giessen, Germany.
   [Lyczko, Jacek] Wroclaw Univ Environm & Life Sci, Fac Biotechnol & Food Sci, Dept Chem, Norwida 25, PL-50375 Wroclaw, Poland.
C3 Wroclaw University of Environmental & Life Sciences; Justus Liebig
   University Giessen; Wroclaw University of Environmental & Life Sciences
RP Marycz, K (corresponding author), Wroclaw Univ Environm & Life Sci, Dept Expt Biol, Norwida 27B St,A7 Bldg, PL-50375 Wroclaw, Poland.; Marycz, K (corresponding author), Int Inst Translat Med, Jesionowa 11, PL-55114 Malin, Wisznia Mala, Poland.; Marycz, K (corresponding author), Justus Liebig Univ, Fac Vet Med, Equine Clin, Equine Surg, D-35392 Giessen, Germany.
EM krzysztofmarycz@interia.pl
RI Łyczko, Jacek/S-5629-2019; Bourebaba, Lynda/AAX-7613-2020
FU National Science Centre in Poland [2018/29/B/NZ7/02662,
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FX The work was supported by grant from the National Science Centre in
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   as an innovative method of restoring stemness of adipose-derived stem
   cells isolated from horses suffering from metabolic syndrome (EMS)"
   (2017/27/N/NZ7/02343).
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NR 72
TC 21
Z9 21
U1 1
U2 14
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1757-6512
J9 STEM CELL RES THER
JI Stem Cell Res. Ther.
PD FEB 3
PY 2021
VL 12
IS 1
AR 97
DI 10.1186/s13287-020-02102-x
PG 18
WC Cell & Tissue Engineering; Cell Biology; Medicine, Research &
   Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Research & Experimental Medicine
GA QF3JR
UT WOS:000616794800002
PM 33536069
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Sanyal, AJ
AF Sanyal, AJ
TI Mechanisms of disease: pathogenesis of nonalcoholic fatty liver disease
SO NATURE CLINICAL PRACTICE GASTROENTEROLOGY & HEPATOLOGY
LA English
DT Review
DE fatty liver; insulin resistance; metabolic syndrome; nonalcoholic fatty
   liver disease; nonalcoholic steatohepatitis
ID ELEMENT-BINDING PROTEIN; DE-NOVO LIPOGENESIS; INSULIN-RESISTANCE;
   TRANSCRIPTION FACTORS; GENE-TRANSCRIPTION; X RECEPTOR; STEATOHEPATITIS;
   EXPRESSION; ALPHA; CARBOHYDRATE
AB Nonalchoholic fatty liver disease (NFALD) is associated with the metabolic syndrome. The metabolic syndrome is characterized by insulin resistance, which is produced by a complex interaction between genetic factors, macronutrient intake and lifestyle that alters the cytokine profile factors, micronutrient intake and lifestyle that alters the cytokine profile, cell biology and biochemical milieu of the liver, adipose tissue and striated muscle. The resultant disequilibrium in lipid homeostasis causes triglycerides to accumulate in the liver. An increase in oxidative stress, due to the generation of reactive oxygen species as a result of mithochondrial abnormalities and induction of the cythochrome P-450 system could be one mechanism by which the nonalcoholic steatohepatitis. The pathogenesis of cyctologic balloning and Mallory body formation and their role in NAFLD remain to be defined. In addition, inflammation and fibrosis are likely to be secondary to hepatocyte injury and death.
C1 Virginia Commonwealth Univ, Div Gastroenterol Hepatol & Nutr, Dept Internal Med, Med Ctr, Richmond, VA 23298 USA.
C3 Virginia Commonwealth University
RP Virginia Commonwealth Univ, Div Gastroenterol Hepatol & Nutr, Dept Internal Med, Med Ctr, MCV Box 980341, Richmond, VA 23298 USA.
EM ajsanyal@hsc.vcu.edu
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NR 48
TC 177
Z9 198
U1 1
U2 23
PU NATURE PUBLISHING GROUP
PI NEW YORK
PA 75 VARICK ST, 9TH FLR, NEW YORK, NY 10013-1917 USA
SN 1743-4378
J9 NAT CLIN PRACT GASTR
JI Nat. Clin. Pract. Gastroenterol. Hepatol.
PD JAN
PY 2005
VL 2
IS 1
BP 46
EP 53
DI 10.1038/ncpgasthep0084
PG 8
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 925FR
UT WOS:000229038200013
PM 16265100
DA 2025-06-11
ER

PT J
AU Cañete, JD
   Tasende, JAP
   Laserna, FJR
   Castro, SG
   Queiro, R
AF Canete, Juan D.
   Pinto Tasende, Jose Antonio
   Rebollo Laserna, Francisco Jose
   Gomez Castro, Susana
   Queiro, Ruben
TI The Impact of Comorbidity on Patient-Reported Outcomes in Psoriatic
   Arthritis: A Systematic Literature Review
SO RHEUMATOLOGY AND THERAPY
LA English
DT Review
DE Comorbidity; Patient-reported outcomes; Psoriatic arthritis; Systematic
   literature review
ID QUALITY-OF-LIFE; CARDIOVASCULAR RISK-FACTORS; MINIMAL DISEASE-ACTIVITY;
   ANKYLOSING-SPONDYLITIS; RHEUMATOID-ARTHRITIS; WORK DISABILITY;
   DEPRESSIVE SYMPTOMS; METABOLIC SYNDROME; ANXIETY; SLEEP
AB Introduction A systematic literature review was conducted with the aim to analyse the impact of comorbidity on patient-reported outcomes (PROs) in patients with psoriatic arthritis (PsA). Methods A sensitive search strategy of the Medline, Embase and the Cochrane Library (up to March 2019) was applied to retrieve studies for inclusion in this systematic literature review. s of the ACR and EULAR scientific meetings were also searched. The selection criteria were: (1) patients with PsA (population) with a comorbidity (intervention) and (2) report of any impact of the comorbidity on PROs. Systematic literature reviews, randomized controlled trials and observational were included in this systematic literature review. Two of the authors selected the articles and collected the data. Results Eighteen articles were included in this systematic literature review, with most being cross-sectional studies that included more than 9000 patients with PsA. Some studies analysed the impact of an individual comorbidity, such as fibromyalgia (FM), and in others the analysis was according to the number of comorbidities. The most frequently analysed PROs were function, quality of life and fatigue. Analysis of the studies included in the review showed that patients with a higher number of comorbidities and/or more severe comorbidities reported worse impacts of their disease on function, patient's global assessment (PGA), pain, fatigue, work disability and quality of life. Specifically, FM had a negative impact on the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), function, quality of sleep and quality of life; anxiety and depression had a negative impact on function and fatigue; metabolic syndrome had a negative impact on BASDAI, function, PGA and quality of life; obesity had a negative impact on function and pain; smoking (current and ex-smokers) had a negative impact on pain, function, fatigue, quality of life and overall health; alcohol intake had a negative impact on pain, function, fatigue, quality of life and overall health. Conclusions The prevalence and impact of medical comorbidity on PROs are very high in patients with PsA.
C1 [Canete, Juan D.] Hosp Clin IDIBAPS, Rheumatol Dept, Arthrit Unit, Barcelona, Spain.
   [Pinto Tasende, Jose Antonio] Complexo Hosp Univ A Coruna, Rheumatol Dept, INIBIC, La Coruna, Spain.
   [Rebollo Laserna, Francisco Jose; Gomez Castro, Susana] Pfizer Med Dept, Madrid, Spain.
   [Queiro, Ruben] Hosp Univ Cent Asturias, Rheumatol Dept, Oviedo, Spain.
C3 University of Barcelona; Hospital Clinic de Barcelona; IDIBAPS;
   Universidade da Coruna; Instituto de Investigacion Biomedica de A Coruna
   (INIBIC); Complejo Hospitalario Universitario A Coruna; Pfizer; Pfizer
   Spain; Central University Hospital Asturias
RP Queiro, R (corresponding author), Hosp Univ Cent Asturias, Rheumatol Dept, Oviedo, Spain.
EM rubenque7@yahoo.es
RI Pinto-Tasende, Jose/ABA-5239-2021; Canete, Juan D/M-4428-2017; Queiro,
   Ruben/D-5358-2016
OI Canete, Juan D/0000-0003-2606-0573; Queiro, Ruben/0000-0002-8418-7145
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NR 97
TC 29
Z9 29
U1 0
U2 15
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 2198-6576
EI 2198-6584
J9 RHEUMATOL THER
JI Rheumatol. Ther.
PD JUN
PY 2020
VL 7
IS 2
BP 237
EP 257
DI 10.1007/s40744-020-00202-x
PG 21
WC Rheumatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Rheumatology
GA LK9JW
UT WOS:000531175600001
PM 32270447
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Asbury, EA
   Collins, P
AF Asbury, EA
   Collins, P
TI Psychosocial factors associated with noncardiac chest pain and cardiac
   syndrome X
SO HERZ
LA English
DT Article
DE angina; psychological morbidity; syndrome X; NCCP
ID NORMAL CORONARY-ARTERIES; TRANSCENDENTAL-MEDITATION-TECHNIQUE;
   HEART-FOCUSED ANXIETY; QUALITY-OF-LIFE; FOLLOW-UP; PSYCHOLOGICAL
   TREATMENT; CONTROLLED TRIAL; SYMPTOMS; WOMEN; MENOPAUSE
AB Cardiac syndrome X, the triad of angina pectoris, positive exercise electrocardiogram (ECG) for myocardial ischemia and angiographically smooth coronary arteries, is associated with increased psychological morbidity, debilitating symptomatology and a poor quality of life. Patients with noncardiac chest pain (NCCP) are often similarly affected. The psychological morbidity noted among this patient population has been linked with a number of psychosocial factors, including impaired social support, traumatic life events, the negative impact of menopause among female sufferers, and an awareness of a family history of coronary heart disease (CHD). Cognitive behavioral therapy (CBT), group support, physical activity and relaxation techniques have been investigated as treatments for psychological morbidity among this patient group with varying degrees of success. While clinicians should be aware of the psychological aspect of patients with NCCP and cardiac syndrome X, further research is needed in order to establish a comprehensive physiological and psychological treatment regimen.
C1 Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, Dept Cardiac Med, London SW3 6LY, England.
C3 Imperial College London
RP Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, Dept Cardiac Med, Dovehouse St, London SW3 6LY, England.
EM e.asbury@imperial.ac.uk
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NR 54
TC 16
Z9 16
U1 0
U2 7
PU URBAN & VOGEL
PI MUNICH
PA NEUMARKTER STRASSE 43, D-81673 MUNICH, GERMANY
SN 0340-9937
EI 1615-6692
J9 HERZ
JI Herz
PD FEB
PY 2005
VL 30
IS 1
BP 55
EP 60
DI 10.1007/s00059-005-2649-x
PG 6
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Cardiovascular System & Cardiology
GA 906NQ
UT WOS:000227649300008
PM 15754156
DA 2025-06-11
ER

PT J
AU Johnson, PJ
AF Johnson, PJ
TI The equine metabolic syndrome peripheral Cushing's syndrome
SO VETERINARY CLINICS OF NORTH AMERICA-EQUINE PRACTICE
LA English
DT Article
ID DEPENDENT DIABETES-MELLITUS; INDUCED ACUTE LAMINITIS;
   INSULIN-RESISTANCE; ENDOTHELIAL DYSFUNCTION; GLUCOSE-TOLERANCE;
   LIPID-METABOLISM; OXIDATIVE STRESS; ENDOCRINE ORGAN; HEALTHY HORSES;
   GLYCEMIC INDEX
AB The equine metabolic syndrome is a common condition of mature adult horses that results from a constellation of endocrinological disturbances. Similar to its human counterpart, the equine metabolic syndrome develops in genetically susceptible individuals that have been subjected to overfeeding practices and relative inactivity. Affected horses are usually obese and are presented to veterinarians for the treatment of laminitis. Two important endocrinopathic consequences of obesity include insulin insensitivity (hyperinsulinemia) and dysregulated endogenous glucocorticoid metabolism by peripheral tissues. Laminitis (or lamellar stretching) may arise in affected horses as a result of both abnormal endothelial regulation of underlying vascular smooth muscle and cortisol-induced connective tissue and epidermal changes. Unless the patient has been severely compromised by painful lameness (laminitis), affected horses may recover to become serviceable if obesity can be reversed by a combination of enhanced exercise and a ration characterized by a low glycemic index.
C1 Univ Missouri, Vet Med Teaching Hosp, Coll Vet Med, Columbia, MO 65211 USA.
C3 University of Missouri System; University of Missouri Columbia
RP Univ Missouri, Vet Med Teaching Hosp, Coll Vet Med, Clydesdale Hall, Columbia, MO 65211 USA.
EM johnsonpj@missouri.edu
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NR 88
TC 195
Z9 233
U1 0
U2 86
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0749-0739
EI 1558-4224
J9 VET CLIN N AM-EQUINE
JI Vet. Clin. N. Am.-Equine Pract.
PD AUG
PY 2002
VL 18
IS 2
BP 271
EP +
AR PII S0749-0739(02)0006-8
DI 10.1016/S0749-0739(02)00006-8
PG 24
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA 599CA
UT WOS:000178315500005
PM 15635908
DA 2025-06-11
ER

PT J
AU Meydan, C
   Bekenstein, U
   Soreq, H
AF Meydan, Chanan
   Bekenstein, Uriya
   Soreq, Hermona
TI Molecular Regulatory Pathways Link Sepsis With Metabolic Syndrome:
   Non-coding RNA Elements Underlying the Sepsis/Metabolic Cross-Talk
SO FRONTIERS IN MOLECULAR NEUROSCIENCE
LA English
DT Article
DE metabolic syndrome; miRs; ncRNAs; sepsis; SNPs
ID CARDIAC RESYNCHRONIZATION THERAPY; HEART-FAILURE; CIRCULATING
   MICRORNA-30D; CARDIOMYOCYTE APOPTOSIS; POSTTRAUMATIC-STRESS;
   ATRIAL-FIBRILLATION; ADIPOSE-TISSUE; EXPRESSION; ACTIVATION; IMMUNITY
AB Sepsis and metabolic syndrome (MetS) are both inflammation-related entities with high impact for human health and the consequences of concussions Both represent imbalanced parasympathetic/cholinergic response to insulting triggers and variably uncontrolled inflammation that indicates shared upstream regulators, including short microRNAs (miRs) and long non-coding RNAs (IncRNAs). These may cross talk across multiple systems, leading to complex molecular and clinical outcomes. Notably, biomedical and RNA-sequencing based analyses both highlight new links between the acquired and inherited pathogenic, cardiac and inflammatory traits of sepsis/MetS. Those include the HOTAIR and MIAT IncRNAs and their targets, such as miR-122, -150, -155, -182, -197, -375, -608 and HLA-DRA. Implicating non-coding RNA regulators in sepsis and MetS may delineate novel high-value biomarkers and targets for intervention.
C1 [Meydan, Chanan] Mayanei Hayeshua Med Ctr, Dept Internal Med, Bnei Braq, Israel.
   [Bekenstein, Uriya; Soreq, Hermona] Hebrew Univ Jerusalem, Edmond & Lilly Safra Ctr Brain Sci, Alexander Silberman Inst Life Sci, Dept Biol Chem, Jerusalem, Israel.
C3 Tel Aviv University; Hebrew University of Jerusalem
RP Soreq, H (corresponding author), Hebrew Univ Jerusalem, Edmond & Lilly Safra Ctr Brain Sci, Alexander Silberman Inst Life Sci, Dept Biol Chem, Jerusalem, Israel.
EM hermona.soreq@mail.huji.ac.il
RI Soreq, Hermona/AFM-0869-2022
OI Meydan, Chanan/0000-0002-8824-6309; Soreq, Hermona/0000-0002-0955-526X
FU European Research Council [321501]; Israeli Ministry of Science,
   Technology and Space [53140]; Legacy Heritage Science Initiative (LHSI)
   of The Israel Science Foundation [817/13]; Austrian Research Promotion
   Agency (FFG Bridge1 project; Osterreichische
   Forschungsforderungsgesellschaft) [853294]; Edmond and Lily Safra Center
   for Brain Sciences (ELSC); Howard and Diana Wendy pre-doctoral
   fellowship; Israel I-Core Center of Excellence for Mass Trauma [817/13]
FX This research was supported by the European Research Council (Advanced
   Award 321501), The Israeli Ministry of Science, Technology and Space,
   Grant No. 53140, The Israel I-Core Center of Excellence for Mass Trauma
   and The Legacy Heritage Science Initiative (LHSI) of The Israel Science
   Foundation Grant No. 817/13, The Austrian Research Promotion Agency (FFG
   Bridge1 project; Osterreichische Forschungsforderungsgesellschaft, Grant
   number 853294) and the Edmond and Lily Safra Center for Brain Sciences
   (ELSC, to HS); UB was supported by the Howard and Diana Wendy
   pre-doctoral fellowship.
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NR 115
TC 22
Z9 24
U1 0
U2 8
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1662-5099
J9 FRONT MOL NEUROSCI
JI Front. Molec. Neurosci.
PD JUN 5
PY 2018
VL 11
AR 189
DI 10.3389/fnmol.2018.00189
PG 14
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA GI2IU
UT WOS:000434194200001
PM 29922126
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Rivas-Urbina, A
   Benitez, S
   Perez, A
   Sanchez-Quesada, JL
AF Rivas-Urbina, Andrea
   Benitez, Sonia
   Perez, Antonio
   Luis Sanchez-Quesada, Jose
TI Modified low-density lipoproteins as biomarkers in diabetes and
   metabolic syndrome
SO FRONTIERS IN BIOSCIENCE-LANDMARK
LA English
DT Article
DE Diabetes; metabolic syndrome; atherosclerosis; cardiovascular risk;
   biomarkers; modified LDL; oxidized LDL; AGE-LDL; glycosylated LDL;
   electronegative LDL
ID CIRCULATING IMMUNE-COMPLEXES; CORONARY-HEART-DISEASE; INTIMA-MEDIA
   THICKNESS; MODIFIED APOLIPOPROTEIN B100; NONESTERIFIED FATTY-ACIDS;
   OXIDIZED LDL; ELECTRONEGATIVE LDL; CARDIOVASCULAR-DISEASE;
   MYOCARDIAL-INFARCTION; IGG ANTIBODIES
AB Cardiovascular disease of atherosclerotic origin is the main cause of death in diabetes mellitus and metabolic syndrome. One of the mechanisms involved in such increased risk is the high incidence of lipoprotein modification in these pathologies. Increased glycosylation, oxidative stress or high non-esterified fatty acid levels in blood, among other factors, promote the modification and subsequent alteration of the properties of lipoproteins. Since the modification of low-density lipoprotein (LDL) is the triggering factor in the development of atherosclerosis, considerable research has been focused on the quantification of modified LDLs in blood to be used as biomarkers of cardiovascular risk. The present review deals with the main molecular mechanisms involved in the modification of LDL in diabetes and metabolic syndrome and briefly describe the atherogenic effects that these modified LDLs exert on the arterial wall. The possibility of using the high levels of modified LDLs or their immunocomplexes as a predictive tool for cardiovascular risk in diabetes-related pathologies is also discussed.
C1 [Rivas-Urbina, Andrea; Benitez, Sonia; Luis Sanchez-Quesada, Jose] Hosp St Pau IIB St Pau, Cardiovasc Biochem Grp, Res Inst, Barcelona, Spain.
   [Rivas-Urbina, Andrea] Univ Autonoma Barcelona, Biochem & Mol Biol Dept, Cerdanyola Del Valles, Spain.
   [Perez, Antonio] Hosp Santa Creu I St Pau, Endocrinol & Nutr Dept, Barcelona, Spain.
   [Perez, Antonio; Luis Sanchez-Quesada, Jose] Inst Hlth Carlos III, CIBERDEM, Madrid, Spain.
C3 Autonomous University of Barcelona; CIBER - Centro de Investigacion
   Biomedica en Red; CIBERDEM
RP Sanchez-Quesada, JL (corresponding author), Hosp St Pau IIB St Pau, Cardiovasc Biochem Grp, Res Inst, Barcelona, Spain.
EM jsanchezq@santpau.cat
RI Benitez, Sonia/JWO-2907-2024
OI Rivas-Urbina, Andrea/0000-0002-0111-0477
FU FEDER funds; Instituto de Salud Carlos III from the Ministry of Health
   (CIBERDEM) [FIS PI13-00364, FIS PI16-0471]; AGAUR from the Generalitat
   de Catalunya [2014-SGR-246]
FX The authors of this study have been funded with FEDER funds and by the
   Instituto de Salud Carlos III from the Ministry of Health (CIBERDEM, FIS
   PI13-00364, FIS PI16-0471) and by AGAUR from the Generalitat de
   Catalunya (2014-SGR-246).
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NR 168
TC 16
Z9 16
U1 0
U2 10
PU FRONTIERS IN BIOSCIENCE INC
PI IRVINE
PA 16471 SCIENTIFIC WAY, IRVINE, CA 92618 USA
SN 1093-9946
EI 1093-4715
J9 FRONT BIOSCI-LANDMRK
JI Front. Biosci.
PD JAN 1
PY 2018
VL 23
BP 1220
EP 1240
DI 10.2741/4640
PG 21
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA GN4WX
UT WOS:000439042100002
PM 28930596
DA 2025-06-11
ER

PT J
AU Wang, YL
   Suo, SK
   Shang, Y
   Pan, DD
   Jia, LL
   Lan, J
   Si, XY
   Gao, XC
   Dang, YL
AF Wang, Yanli
   Suo, Shikun
   Shang, Yan
   Pan, Daodong
   Jia, Lingling
   Lan, Jing
   Si, Xiangyu
   Gao, Xinchang
   Dang, Yali
TI Deciphering the effect of soluble dietary fiber from broccoli stem and
   leaf on metabolic syndrome and its hypoglycemic mechanism in diabetes
   mellitus
SO FOOD BIOSCIENCE
LA English
DT Article
DE Broccoli soluble dietary fiber; High-fat diet mice; Metabolic syndrome;
   Hypoglycemic mechanism; Gut microbiota
ID ANTIOXIDANT ACTIVITIES; GUT MICROBIOTA; POLYSACCHARIDES; INFLAMMATION;
   EXTRACTION; RECEPTOR; GLUCOSE; HEALTH; MICE
AB Consumption of broccoli contributes to the maintenance of glucose homeostasis due to its high dietary fiber. Nevertheless, the effects of soluble dietary fiber from broccoli stem and leaf (B-SDF) on diabetes-related metabolic syndrome and its hypoglycemic mechanism remain ambiguous. This study is aimed at exploring the beneficial influences of B-SDF on ameliorating metabolic syndrome and revealing the hypoglycemic mechanism by gut microbiota composition. Administration with B-SDF mitigated various metabolic syndromes in mice induced by high-fat diet (HFD), including weight gain, glucose intolerance, oxidative stress (superoxide dismutase and malondialdehyde), renal dysfunction (urea, creatinine, and uric acid), liver damage and lipid accumulation. Furthermore, gut microbiota dysbiosis in HFD mice was ameliorated by B-SDF supplementation, which significantly reduced the proportion of Firmicutes and increased the abundance of Bacteroidetes (p < 0.05) compared with the HFD group. The gut microbiota composition was reshaped by elevating the level of Eubacterium and decreasing the numbers of Lachnospiraceae NK4A136 and Alistipes in HFD mice. These novel findings demonstrate the potential of B-SDF as a valuable ingredient in prebiotics or functional foods for diabetes management.
C1 [Wang, Yanli; Suo, Shikun; Shang, Yan; Pan, Daodong; Jia, Lingling; Lan, Jing; Dang, Yali] Ningbo Univ, Coll Food Sci & Engn, Ningbo 315211, Peoples R China.
   [Wang, Yanli; Suo, Shikun; Shang, Yan; Pan, Daodong; Jia, Lingling; Lan, Jing; Dang, Yali] Ningbo Univ, Zhejiang Key Lab Intelligent Food Logist & Proc, Ningbo 315211, Peoples R China.
   [Gao, Xinchang] Ningbo Univ, Inst Drug Discovery Technol, Ningbo 315211, Peoples R China.
   [Si, Xiangyu] Zhengzhou Qihuali Sci & Trade Co Ltd, Zhengzhou 450000, Peoples R China.
C3 Ningbo University; Ningbo University; Ningbo University
RP Dang, YL (corresponding author), Ningbo Univ, Coll Food Sci & Engn, Ningbo 315211, Peoples R China.; Gao, XC (corresponding author), Ningbo Univ, Inst Drug Discovery Technol, Ningbo 315211, Peoples R China.
EM gaoxinchang@nbu.edu.cn; dangyali@nbu.edu.cn
RI dang, dang/AAE-7103-2021
FU Xinjiang Production and Construction Corps [2024AB053]; One health
   Interdisciplinary Research Project, Ningbo University [HZ202202,
   2023K100]; Student Research Project, Ningbo University [2024R405A061]
FX This work was supported by the Science center dot Technology center dot
   Department center dot of Zhejiang Province (2024C01248 (SD2),
   2022C02028), the Department of Agriculture and Rural Affairs of Zhejiang
   Province (2025SNJF038), the Scientific and Technological Research
   Projects in Key Areas of Xinjiang Production and Construction Corps
   (2024AB053), the One health Interdisciplinary Research Project, Ningbo
   University (HZ202202), the Quzhou City center dot Science and Technology
   center dot Plan center dot Project (2023K100), and the Student Research
   Project, Ningbo University (2024R405A061).
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NR 60
TC 0
Z9 0
U1 7
U2 7
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2212-4292
EI 2212-4306
J9 FOOD BIOSCI
JI Food Biosci.
PD JUN
PY 2025
VL 68
AR 106546
DI 10.1016/j.fbio.2025.106546
PG 11
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA 2JP4S
UT WOS:001484210200001
DA 2025-06-11
ER

PT J
AU Peng, Y
   Teng, XY
   Liu, TZ
   Li, YH
   Ni, JY
   Xue, SL
   Wang, J
AF Peng, Yu
   Teng, Xiaoyue
   Liu, Tingzhu
   Li, Yuhan
   Ni, Jiayi
   Xue, Siliang
   Wang, Juan
TI Effect of an oral probiotic formula on scalp and facial skin condition,
   glucose, and lipid metabolism
SO FUNCTIONAL FOODS IN HEALTH AND DISEASE
LA English
DT Article
DE hair density; hair loss; metabolic syndrome; oral probiotic
   supplementation
ID LACTOBACILLUS-ACIDOPHILUS NCFM; PARACASEI NCC2461 ST11; DOUBLE-BLIND;
   BIFIDOBACTERIUM-LACTIS; DIETARY CONSUMPTION; RHAMNOSUS HN001; FERMENTED
   MILK; SLEEP QUALITY; MICROBIOTA; HEALTH
AB Objective: We conducted this study to explore the effect of oral probiotic supplementation on hair density as a primary outcome in subjects with hair loss and at high risk of metabolic syndrome. The secondary objectives were to assess probiotic effects on skin barrier function,metabolic health and stress responses.
   Methods: We supplemented the diets of Chinese adults presenting with hair loss and high risk of metabolic syndrome (n = 26, male gender 38.5%, age = 33.6 +/- 4.5 years) with a multi-strain probiotic formula at a dosage of 18.1 billion colony forming units (CFU) twice daily for 12 weeks. We compared the hair density, hair loss, anthropometrics measures, blood biochemistry markers, skin biophysical characteristics and stress-associated responses between baseline and the end of the trial.
   Results: After 12 weeks of probiotic supplementation, 96.2% of the study participants had improvement in hair density (median density level increased: 1; interquartile range: 1-2). Participants reported reduced hair loss both quantitatively and qualitatively. The majority (73.1%) of the participants reported apparent relief of scalp itching. Stratum corneum hydration and pH increased, while transepidermal water loss and sebum decreased on both scalp and facial skin. Body weight and body mass index decreased following probiotic consumption. Most components of glucose metabolism and the lipid profile were significantly better, with increases in high-density lipoprotein cholesterol and reductions in glucose, homeostasis model assessment-estimated insulin resistance, total cholesterol, non-high-density lipoprotein cholesterol and triglycerides. Inflammation and oxidative stress markers improved with increases in interferon-gamma and superoxide dismutase, and reductions in high-sensitivity C-reactive protein, interleukin-6, interleukin-31 and malondialdehyde. No changes were observed in glycated hemoglobin, insulin, immunoglobulin E and interleukin-10 levels. Besides, perceived stress relieved in participants accompanied with improved sleep quality as well as better overall perception of life quality and health.
   Conclusion: Twice-daily supplementation with the test probiotic formula over a 12-weeks period may exert profound beneficial effects on hair growth, skin condition, glucose and lipid metabolism, and stress-associated psychological and physiological responses in participants presenting with hair loss and high risk of metabolic syndrome.
C1 [Peng, Yu] Harbin Inst Technol, Sch Chem & Chem Engn, Harbin, Peoples R China.
   [Teng, Xiaoyue; Xue, Siliang] Sichuan Univ, West China Hosp, Dept Dermatol, Chengdu, Sichuan, Peoples R China.
   [Liu, Tingzhu; Li, Yuhan; Wang, Juan] Memoo Beijing Technol Co Ltd, Beijing, Peoples R China.
   [Ni, Jiayi] Sprim China Consulting Co Ltd, Shanghai, Peoples R China.
C3 Harbin Institute of Technology; Sichuan University
RP Xue, SL (corresponding author), Sichuan Univ, West China Hosp, Dept Dermatol, Chengdu, Sichuan, Peoples R China.; Wang, J (corresponding author), Memoo Beijing Technol Co Ltd, Beijing, Peoples R China.
RI Li, YuHan/GZM-2095-2022; Xue, Siliang/HLQ-3641-2023
FU Memoo (Beijing) Technology Co. Ltd.
FX The authors would like to thank Dr. Li Zhang and his colleagues from
   Sprim China for their excellent work in coordinating the study, and
   Raison Testing Lab for performing the biomarkers test. The study was
   funded by Memoo (Beijing) Technology Co. Ltd.
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NR 69
TC 6
Z9 6
U1 0
U2 14
PU FUNCTIONAL FOOD CENTER INC
PI DALLAS
PA 5050 QUORUM DR, STE 700,  NO 338, DALLAS, TX 75254 USA
SN 2160-3855
J9 FUNCT FOODS HEALTH D
JI Funct. Foods Health Dis.
PD JUL
PY 2022
VL 12
IS 7
BP 394
EP 409
DI 10.31989/ffhd.v12i7.944
PG 16
WC Food Science & Technology
WE Emerging Sources Citation Index (ESCI)
SC Food Science & Technology
GA 3L4NZ
UT WOS:000834740500002
OA gold
DA 2025-06-11
ER

PT J
AU Lee, DH
   Song, J
AF Lee, Dong Hoon
   Song, Juhyun
TI Impaired olfactory system in metabolic imbalance-related neuropathology
SO LIFE SCIENCES
LA English
DT Article
DE Olfactory dysfunction; Metabolic imbalance; Olfactory bulb;
   Neuropathology
ID BRAIN INSULIN-RECEPTOR; NEUROPEPTIDE-Y; KV1.3 CHANNEL; BULB NEURONS;
   BODY-WEIGHT; RAT-BRAIN; OBESITY; LEPTIN; MICE; MODULATION
AB Olfactory dysfunction, influenced by factors such as aging and environmental stress, is linked to various neurological disorders. The olfactory bulb's connections to brain areas like the hypothalamus, piriform cortex, entorhinal cortex, and limbic system make olfactory dysfunction a contributor to a range of neuropathological conditions. Recent research has underscored that olfactory deficits are prevalent in individuals with both metabolic syndrome and dementia. These systemic metabolic alterations correlate with olfactory impairments, potentially affecting brain regions associated with the olfactory bulb. In cases of metabolic syndrome, phenomena such as insulin resistance and disrupted glucose metabolism may result in compromised olfactory function, leading to multiple neurological issues. This review synthesizes key findings on the interplay between metabolic-induced olfactory dysfunction and neuropathology. It emphasizes the critical role of olfactory assessment in diagnosing and managing neurological diseases related to metabolic syndrome.
C1 [Lee, Dong Hoon] Chonnam Natl Univ, Med Sch, Dept Otolaryngol Head & Neck Surg, Hwasun, Jeonnam, South Korea.
   [Lee, Dong Hoon] Hwasun Hosp, Hwasun 58128, South Korea.
   [Song, Juhyun] Chonnam Natl Univ, Dept Anat, Med Sch, Hwasun 58128, South Korea.
C3 Chonnam National University; Chonnam National University
RP Song, J (corresponding author), Chonnam Natl Univ, Dept Anat, Med Sch, Hwasun 58128, South Korea.
EM leen3l@chonnam.ac.kr; juhyunsong@chonnam.ac.kr
FU National Research Foundation of Korea (NRF) [NRF-2022R1A2C1006125];
   Chonnam National University Hwasun Hospital Institute for Biomedical
   Science, Korea [HCRI24023]
FX Acknowledgements This study was supported by grant NRF-2022R1A2C1006125
   (Juhyun Song) from the National Research Foundation of Korea (NRF) .
   HCRI24023 from the Chonnam National University Hwasun Hospital Institute
   for Biomedical Science, Korea (Juhyun Song, Dong Hoon Lee) . The authors
   thank Biorender for making the figures
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NR 79
TC 2
Z9 2
U1 6
U2 10
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0024-3205
EI 1879-0631
J9 LIFE SCI
JI Life Sci.
PD OCT 15
PY 2024
VL 355
AR 122967
DI 10.1016/j.lfs.2024.122967
EA AUG 2024
PG 7
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA E2J5E
UT WOS:001301316700001
PM 39142504
OA hybrid
DA 2025-06-11
ER

PT J
AU Seckl, JR
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AF Seckl, JR
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TI Glucocorticoids and 11beta-hydroxysteroid dehydrogenase in adipose
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SO RECENT PROGRESS IN HORMONE RESEARCH, VOL 59
SE RECENT PROGRESS IN HORMONE RESEARCH
LA English
DT Review
ID BODY-FAT DISTRIBUTION; BETA-HYDROXYSTEROID DEHYDROGENASE;
   PITUITARY-ADRENAL AXIS; OBESE ZUCKER RATS; LOW-BIRTH-WEIGHT; HEPATIC
   INSULIN SENSITIVITY; CARDIOVASCULAR RISK-FACTORS; PLACENTAL
   11-BETA-HYDROXYSTEROID DEHYDROGENASE; APPARENT MINERALOCORTICOID EXCESS;
   CORTISONE REDUCTASE DEFICIENCY
AB The highly prevalent metabolic syndrome (insulin resistance, type 2 diabetes, dyslipidemia, hypertension, along with abdominal obesity) resembles Cushing's syndrome. However, in simple obesity, plasma cortisol levels are not elevated. 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1), at least in mature adipocytes and hepatocytes, converts inactive circulating 11-keto steroids into active glucocorticoids, amplifying local glucocorticoid action. 11beta-HSD1 is elevated in adipose tissue in obese humans and rodents, suggesting that adipose tissue glucocorticoid excess may explain the conundrum. Indeed, transgenic mice overexpressing 11beta-HSD1 in adipose tissue faithfully replicate the metabolic syndrome. Conversely, 110-HSD1(-/-) mice resist the metabolic consequences of stress and high-fat feeding via insulin sensitisation and other advantageous effects in the liver and adipose tissue. Adipose 11beta-HSD1 deficiency contributes to a protective metabolic phenotype, supporting its role as a therapeutic target for the metabolic syndrome.
C1 Univ Edinburgh, Western Gen Hosp, Sch Mol & Clin Med, Endocrinol Unit, Edinburgh EH4 2XU, Midlothian, Scotland.
C3 University of Edinburgh
RP Seckl, JR (corresponding author), Univ Edinburgh, Western Gen Hosp, Sch Mol & Clin Med, Endocrinol Unit, Edinburgh EH4 2XU, Midlothian, Scotland.
RI Morton, NICHOLAS/ABF-3774-2020; Seckl, Jonathan/C-3555-2013
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NR 181
TC 175
Z9 195
U1 0
U2 11
PU ENDOCRINE SOC
PI BETHESDA
PA 4350 EAST WEST HIGHWAY SUITE 500, BETHESDA, MD 20814-4410 USA
SN 0079-9963
J9 RECENT PROG HORM RES
PY 2004
VL 59
BP 359
EP 393
DI 10.1210/rp.59.1.359
PG 35
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA BY89X
UT WOS:000189490300017
PM 14749510
OA gold
DA 2025-06-11
ER

PT J
AU Zanchet, MZD
   Nardi, GM
   Bratti, LDS
   Filippin-Monteiro, FB
   Locatelli, C
AF de Souza Zanchet, Mayara Zagonel
   Nardi, Geisson Marcos
   Souza Bratti, Leticia de Oliveira
   Filippin-Monteiro, Fabiola Branco
   Locatelli, Claudriana
TI Lycium barbarum Reduces Abdominal Fat and Improves Lipid Profile
   and Antioxidant Status in Patients with Metabolic Syndrome
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Article
ID C-REACTIVE PROTEIN; OXIDATIVE STRESS; CARDIOVASCULAR RISK;
   DIABETES-MELLITUS; INFLAMMATION; POLYSACCHARIDE; INTERVENTION;
   ACCUMULATION; PEROXIDATION; PREVALENCE
AB Natural antioxidants present in fruits have attracted considerable interest due to their presumed safety and potential nutritional value. Even though antioxidant activities of many fruits have been reported, the effects of phytochemicals of goji berry (GB) in patients with metabolic syndrome have not been investigated. In this study, we examined anthropometric and biochemical parameters in patients with metabolic syndrome after the consumption of GB. The patients were divided into two groups, control (C) and supplemented (S), and followed up for 45 days. Participants were individually instructed to carry out a healthy diet, but additionally, an inclusion of 14 g of the natural form of goji berry in the diet during 45 days for the S group was proposed. After 45 days of study, a significant reduction in transaminases as well as an improvement in lipid profile in the S group was observed. Likewise, a significant reduction in the waist circumference of the S group was observed when compared with that of the C group, and increased glutathione and catalase levels associated with a reduction of lipid peroxidation. These results suggest that this is an effective dietary supplement for the prevention of cardiovascular diseases in individuals with metabolic syndrome.
C1 [de Souza Zanchet, Mayara Zagonel] Univ Oeste Santa Catarina UNOESC, Programa Pos Grad Biociencias & Saude, Joacaba, SC, Brazil.
   [Nardi, Geisson Marcos] Univ Fed Mato Grosso UFMT, ICEN, Curso Med, Rondonopolis, MT, Brazil.
   [Souza Bratti, Leticia de Oliveira; Filippin-Monteiro, Fabiola Branco] Univ Fed Santa Catarina, Dept Anal Clin, Florianopolis, SC, Brazil.
   [Locatelli, Claudriana] Univ Oeste Santa Catarina UNOESC, Lab Bioquim Expt, Joacaba, SC, Brazil.
C3 Universidade do Oeste de Santa Catarina; Universidade Federal de Mato
   Grosso do Sul; Universidade Federal de Santa Catarina (UFSC);
   Universidade do Oeste de Santa Catarina
RP Locatelli, C (corresponding author), Univ Oeste Santa Catarina UNOESC, Lab Bioquim Expt, Joacaba, SC, Brazil.
EM claudriana.locatelli@unoesc.edu.br
RI Locatelli, Claudriana/I-7555-2016; Nardi, Geisson/JNR-2897-2023; Nardi,
   Geisson Marcos/C-6640-2014; Filippin Monteiro, Fabiola
   Branco/D-6509-2018
OI Nardi, Geisson Marcos/0000-0003-0484-8490; Locatelli,
   Claudriana/0000-0003-4708-6641; Filippin Monteiro, Fabiola
   Branco/0000-0003-4313-1783
FU Master Program of Bioscience and Heath of Universidade do Oeste de Santa
   Catarina-UNOESC
FX This work was supported by the Master Program of Bioscience and Heath of
   Universidade do Oeste de Santa Catarina-UNOESC. The authors thank all
   study participants and coworkers for their assistance in the preparation
   and execution of this study.
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NR 60
TC 33
Z9 33
U1 0
U2 22
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PY 2017
VL 2017
AR 9763210
DI 10.1155/2017/9763210
PG 12
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA EX4KN
UT WOS:000403203500001
PM 28685012
OA Green Published, Green Submitted, hybrid
DA 2025-06-11
ER

PT J
AU Basak, S
   Banerjee, A
   Pathak, S
   Duttaroy, AK
AF Basak, Sanjay
   Banerjee, Antara
   Pathak, Surajit
   Duttaroy, Asim K.
TI Dietary Fats and the Gut Microbiota: Their impacts on lipid-induced
   metabolic syndrome
SO JOURNAL OF FUNCTIONAL FOODS
LA English
DT Article
DE Metabolic syndrome; Short-chain fatty acids; Medium-chain fatty acid;
   Diacylglycerol; Phospholipid; Metabolism; Gut microbiota; n-3 PUFAs;
   Inflammation; Hypertension; CVD risk factors
ID CONJUGATED LINOLEIC-ACID; LONG-CHAIN TRIACYLGLYCEROLS; TISSUE FACTOR
   EXPRESSION; PLASMINOGEN-ACTIVATOR INHIBITOR; PROTEIN-COUPLED RECEPTOR;
   LOW-DENSITY-LIPOPROTEIN; POSTPRANDIAL FACTOR-VII;
   CORONARY-HEART-DISEASE; VON-WILLEBRAND-FACTOR; MIDDLE-AGED MEN
AB The metabolic syndrome (MetS) produces low-grade inflammation, endothelial dysfunction, platelet hyperactivity, oxidative stress and ultimately contributes to cardiovascular disease (CVD) development. Fatty acids such as n-3 and n-6, monounsaturated, conjugated, highly unsaturated, short-chain types, and their metabolism can impact the development of MetS and associated features. Furthermore, the quality and quantity of dietary fats can influence gut microbiota composition that alters an individual's metabolic health. The gut microbiota modulates components of MetS via different mechanisms. The gut microbiota can swing the host metabolic balance in energy homeostasis, gut motility, appetite, lipid and carbohydrate metabolism, and fat storage in the liver. In addition, an impairment of the gut microbial population by a high-fat diet can lead to systemic inflammation and insulin resistance. The review summarizes the impacts of dietary fats on MetS and their interactions with gut microbiota in modulating the risk factors associated with metabolic syndrome. .
C1 [Basak, Sanjay] Indian Council Med Res, ICMR Natl Inst Nutr, Mol Biol Div, Hyderabad, Telangana, India.
   [Banerjee, Antara; Pathak, Surajit] Chettinad Hosp & Res Inst CHRI, Chettinad Acad Res & Educ CARE, Fac Allied Hlth Sci, Dept Med Biotechnol, Chennai 603103, Tamil Nadu, India.
   [Duttaroy, Asim K.] Univ Oslo, Fac Med, Inst Basic Med Sci, Dept Nutr, Oslo, Norway.
C3 Indian Council of Medical Research (ICMR); ICMR - National Institute of
   Nutrition (NIN); University of Oslo
RP Duttaroy, AK (corresponding author), Univ Oslo, Fac Med, Inst Basic Med Sci, Dept Nutr, Oslo, Norway.
EM a.k.duttaroy@medisin.uio.no
RI Duttaroy, Asim/J-9499-2016; Pathak, Surajit/AAH-4022-2020; Banerjee,
   Antara/AAH-4044-2020; Basak, Sanjay/N-1635-2014
OI Basak, Sanjay/0000-0002-8161-5597
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NR 250
TC 30
Z9 34
U1 11
U2 50
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1756-4646
EI 2214-9414
J9 J FUNCT FOODS
JI J. Funct. Food.
PD APR
PY 2022
VL 91
AR 105026
DI 10.1016/j.jff.2022.105026
EA MAR 2022
PG 17
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA ZW1RY
UT WOS:000770998500001
OA gold
DA 2025-06-11
ER

PT J
AU Onat, A
   Ademoglu, E
   Can, G
   Çoban, N
   Kaya, A
   Yüksel, H
AF Onat, Altan
   Ademoglu, Evin
   Can, Gunay
   Coban, Neslihan
   Kaya, Aysem
   Yuksel, Husniye
TI Lower circulating migration inhibitory factor protein is associated with
   metabolic syndrome and diabetes
SO BIOMARKERS IN MEDICINE
LA English
DT Article
DE coronary heart disease; inflammation; metabolic syndrome; serum MIF
   protein; Type 2 diabetes
ID AUGSBURG CASE-COHORT; FACTOR MIF; CARDIOVASCULAR-DISEASE; AUTOIMMUNE
   ACTIVATION; PROINFLAMMATORY STATE; MONONUCLEAR-CELLS; OXIDATIVE STRESS;
   KIDNEY-DISEASE; MACROPHAGE; RISK
AB Aim: The controversial relationship between macrophage migration inhibitory factor (MIF) and the likelihood of cardiometabolic diseases was investigated. Results/methodology: Assayed MIF protein from 1225 adults was cross-sectionally analyzed. MIF was independently inversely associated with age, total testosterone and positively with high-density lipoprotein-cholesterol. In men MIF correlation with age, testosterone and waist circumference converted from inverse in the upper to positive in the bottom MIF third. Both metabolic syndrome and diabetes were significantly associated, in combined gender, with the intermediate (vs the highest) MIF tertile at an odds ratio 1.6. Coronary heart disease was not significantly related with MIF in either gender. Discussion/conclusion: Findings are consistent with oxidative damage to MIF protein and its involvement in autoimmune activation, likely more extensive in women.
C1 [Onat, Altan; Yuksel, Husniye] Istanbul Univ, Cerrahpasa Med Fac, Dept Cardiol, Istanbul, Turkey.
   [Ademoglu, Evin] Istanbul Univ, Istanbul Med Fac, Dept Biochem, Istanbul, Turkey.
   [Can, Gunay] Istanbul Univ, Cerrahpasa Med Fac, Dept Publ Hlth, Istanbul, Turkey.
   [Coban, Neslihan] Istanbul Univ, Inst Expt Med, Dept Genet, Istanbul, Turkey.
   [Kaya, Aysem] Istanbul Univ, Inst Cardiol, Dept Biochem Sect, Istanbul, Turkey.
C3 Istanbul University - Cerrahpasa; Istanbul University; Istanbul
   University; Istanbul University - Cerrahpasa; Istanbul University;
   Istanbul University; Istanbul University
RP Onat, A (corresponding author), Istanbul Univ, Cerrahpasa Med Fac, Dept Cardiol, Istanbul, Turkey.
EM alt_onat@yahoo.com.tr
RI Kaya, Aysem/N-4974-2015; Can, Günay/AAB-1669-2020; Coban,
   Neslihan/AAB-8766-2020; Ademoglu, Evin/AAD-8990-2020
OI Kaya, Aysem/0000-0003-3137-821X; Ademoglu, Evin/0000-0003-2933-3119;
   CAN, GUNAY/0000-0001-5815-6700
FU Turkish Society of Cardiology, Istanbul, Turkey
FX This study received partial funding from the Turkish Society of
   Cardiology, Istanbul, Turkey. The authors have no other relevant
   affiliations or financial involvement with any organization or entity
   with a financial interest in or financial conflict with the subject
   matter or materials discussed in the manuscript apart from those
   disclosed.
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NR 37
TC 3
Z9 3
U1 0
U2 10
PU FUTURE MEDICINE LTD
PI LONDON
PA UNITEC HOUSE, 3RD FLOOR, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON, N3
   1QB, ENGLAND
SN 1752-0363
EI 1752-0371
J9 BIOMARK MED
JI Biomark. Med.
PD JUL
PY 2017
VL 11
IS 7
BP 557
EP 568
DI 10.2217/bmm-2016-0359
PG 12
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA FH5RA
UT WOS:000411224200008
PM 28703031
DA 2025-06-11
ER

PT J
AU Cassano, AE
   White, JR
   Penraat, KA
   Wilson, CD
   Rasmussen, S
   Karatsoreos, IN
AF Cassano, Amy E.
   White, Julie R.
   Penraat, Kelley A.
   Wilson, Christopher D.
   Rasmussen, Skye
   Karatsoreos, Ilia N.
TI Anatomic, Hematologic, and Biochemical Features of C57BL/6NCrl Mice
   Maintained on Chronic Oral Corticosterone
SO COMPARATIVE MEDICINE
LA English
DT Article
ID 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1; METABOLIC SYNDROME; CHRONIC
   STRESS; CUSHINGS-SYNDROME; GLUCOCORTICOID ACTION; INSULIN-RESISTANCE;
   VISCERAL OBESITY; TRANSGENIC MICE; ADIPOSE-TISSUE; MODEL
AB Metabolic syndrome is a condition that typically includes central obesity, insulin resistance, glucose intolerance, dyslipidemia, and hypertension. Disruption of the hypothalamic-pituitary-adrenal axis, a regulator of corticosterone secretion, occurs in some cases of metabolic syndrome and obesity, and Cushing hypercortisolemia is associated with obesity and metabolic disorders. We therefore assessed anatomic and clinical pathology in C57BL/6NCrl mice to evaluate the effects of chronic corticosterone in the drinking water at doses of 25, 50, and 100 mu g/mL for 25 d. Treated mice developed obesity, glucose intolerance, electrolyte aberrations, and dyslipidemia that were dose-dependent and most severe in the 100-mu g/mL treatment group. To evaluate return to normal function, additional C57BL/6NCrl mice received corticosterone-free water for 2 wk after the 25-d treatment period. According to results of gross examination, mice appeared to recover within days of exogenous corticosterone withdrawal; however, adrenal gland vacuolation and protein, lipid, and electrolyte abnormalities persisted. Together, these findings support chronic corticosterone exposure through the drinking water as a potentially useful, noninvasive method to induce some features of metabolic syndrome.
C1 [Cassano, Amy E.; White, Julie R.; Rasmussen, Skye] Weill Cornell Med Coll, Mem Sloan Kettering Canc Ctr, Triinst Training Program Lab Anim Med & Sci, New York, NY USA.
   [Wilson, Christopher D.; Karatsoreos, Ilia N.] Rockefeller Univ, Neuroendocrinol Lab, New York, NY 10021 USA.
   [Penraat, Kelley A.] Alpha Omega Vet Consultant Serv, Lafayette, NJ USA.
C3 Memorial Sloan Kettering Cancer Center; Cornell University; Weill
   Cornell Medicine; Rockefeller University
RP Cassano, AE (corresponding author), Weill Cornell Med Coll, Mem Sloan Kettering Canc Ctr, Triinst Training Program Lab Anim Med & Sci, New York, NY USA.
EM cassano@nyspi.columbia.edu
RI Karatsoreos, Ilia/AAR-8774-2020
FU Rockefeller University
FX We acknowledge Jackie Candelier, Mor Mboup, and Nancy Pinard for their
   technical assistance. This work was supported by The Rockefeller
   University.
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NR 56
TC 24
Z9 26
U1 0
U2 7
PU AMER ASSOC LABORATORY ANIMAL SCIENCE
PI MEMPHIS
PA 9190 CRESTWYN HILLS DR, MEMPHIS, TN 38125 USA
SN 1532-0820
J9 COMPARATIVE MED
JI Comparative Med.
PD OCT
PY 2012
VL 62
IS 5
BP 348
EP 360
PG 13
WC Veterinary Sciences; Zoology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences; Zoology
GA 020GN
UT WOS:000309797100001
PM 23114038
DA 2025-06-11
ER

PT J
AU Kim, SK
   Park, S
   Chang, SJ
   Kim, SK
   Song, JS
   Kim, HR
   Oh, SS
   Koh, SB
AF Kim, Sung-Kyung
   Park, Sungjin
   Chang, Sei-Jin
   Kim, Soo-Ki
   Song, Jae Seok
   Kim, Hyoung-Ryoul
   Oh, Sung-Soo
   Koh, Sang-Baek
TI Pesticides as a risk factor for metabolic syndrome: Population-based
   longitudinal study in Korea
SO MOLECULAR & CELLULAR TOXICOLOGY
LA English
DT Article
DE Pesticide exposure; Metabolic syndrome; Longitudinal study; Incidence;
   South Korean adults; Rural
ID OXIDATIVE STRESS; INSULIN-RESISTANCE; NATIONAL-HEALTH; EXPOSURE; URBAN;
   PREVALENCE; CHEMICALS; PATTERNS; CANCER; ADULTS
AB Backgrounds Metabolic syndrome (MetS) is an adverse health effect that can be associated with pesticide exposure. However, there are few epidemiologic studies on the relationship between pesticide use and MetS incidence. Methods We examined the causal relationship between pesticide use and MetS incidence in a rural population. We used Data from the Korea Farmers Cohort study of 1,162 participants. Poisson regression with a robust error variance was used to calculate relative risks (RRs) and 95% confidence intervals (CIs) to estimate the relationship between pesticide exposure and MetS. Results The incidence of MetS was 20.7%. Pesticide use increased the RR of MetS incidence. In women, we observed a low-dose effect related to MetS and pesticide exposure. Conclusion Pesticide exposure was related to the incidence of MetS; the causal relationship differed in men and women.
C1 [Kim, Sung-Kyung; Park, Sungjin] Yonsei Univ, Grad Sch, Seoul, South Korea.
   [Kim, Sung-Kyung; Chang, Sei-Jin; Oh, Sung-Soo; Koh, Sang-Baek] Yonsei Univ, Wonju Coll Med, Dept Prevent Med, Wonju, South Korea.
   [Kim, Sung-Kyung; Chang, Sei-Jin; Oh, Sung-Soo; Koh, Sang-Baek] Yonsei Univ, Wonju Coll Med, Inst Occupat & Environm Med, Wonju, South Korea.
   [Koh, Sang-Baek] Yonsei Univ, Ctr Global Hlth & Social Med, Inst Poverty Alleviat & Int Dev, Seoul, South Korea.
   [Kim, Soo-Ki] Yonsei Univ, Wonju Coll Med, Dept Microbiol, Wonju, South Korea.
   [Song, Jae Seok] Catholic Kwandong Univ, Dept Prevent Med, Coll Med, Kangnung, South Korea.
   [Kim, Hyoung-Ryoul] Catholic Univ Korea, Coll Med, Dept Occupat & Environm Med, Seoul, South Korea.
   [Park, Sungjin] Hongseong Med Ctr, Dept Occupat & Environm Med, Hongseong, South Korea.
C3 Yonsei University; Yonsei University; Yonsei University; Yonsei
   University; Yonsei University; Catholic Kwandong University; Catholic
   University of Korea
RP Oh, SS; Koh, SB (corresponding author), Yonsei Univ, Wonju Coll Med, Dept Prevent Med, Wonju, South Korea.; Oh, SS; Koh, SB (corresponding author), Yonsei Univ, Wonju Coll Med, Inst Occupat & Environm Med, Wonju, South Korea.; Koh, SB (corresponding author), Yonsei Univ, Ctr Global Hlth & Social Med, Inst Poverty Alleviat & Int Dev, Seoul, South Korea.
EM oss0609@yonsei.ac.kr; kohhj@yonsei.ac.kr
RI Kim, Hyungduk/CAH-5630-2022; Kim, Seong Cheol/ABD-1493-2022; Chang,
   Sei-Jin/A-7254-2018; Kim, Sung-Kyung/GLU-8569-2022; PARK,
   SUNGJIN/AAJ-3406-2020
OI Kim, Sung-Kyung/0000-0002-2742-6410
FU "Cooperative Research Program for Agriculture Science & Technology
   Development" Rural Development Administration, Republic of Korea
   [PJ01250901]
FX This work was conducted with the support of the "Cooperative Research
   Program for Agriculture Science & Technology Development (Project No.
   PJ01250901)" Rural Development Administration, Republic of Korea.
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NR 52
TC 11
Z9 12
U1 0
U2 6
PU KOREAN SOCIETY TOXICOGENOMICS & TOXICOPROTEOMICS-KSTT
PI GYEONGGI-DO
PA HANYANG UNIV, SCI & TECHNOL BLDG 1, RM 423, SA-DONG, SANGROK-GU, ANSAN,
   GYEONGGI-DO, 426 791, SOUTH KOREA
SN 1738-642X
EI 2092-8467
J9 MOL CELL TOXICOL
JI Mol. Cell. Toxicol.
PD OCT
PY 2019
VL 15
IS 4
BP 431
EP 441
DI 10.1007/s13273-019-0047-3
PG 11
WC Biochemistry & Molecular Biology; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Toxicology
GA JC3HJ
UT WOS:000489169500009
DA 2025-06-11
ER

PT J
AU Samouda, H
   De Beaufort, C
   Gilson, G
   Schritz, A
   Vaillant, M
   Ghaddhab, C
   Ruiz-Castell, M
   Huiart, L
   Dohet, F
   Weber, B
   Bohn, T
AF Samouda, Hanen
   De Beaufort, Carine
   Gilson, Georges
   Schritz, Anna
   Vaillant, Michel
   Ghaddhab, Chiraz
   Ruiz-Castell, Maria
   Huiart, Laetitia
   Dohet, Francois
   Weber, Bernard
   Bohn, Torsten
TI Relationship of oxidative stress to visceral adiposity in youth and role
   played by vitamin D
SO PEDIATRIC DIABETES
LA English
DT Article
DE antioxidant; children; obesity; visceral fat; vitamin
ID METABOLIC SYNDROME; DNA-DAMAGE; 8-HYDROXY-2-DEOXYGUANOSINE LEVELS;
   INSULIN-RESISTANCE; SUBCUTANEOUS FAT; PUBERTAL CHANGES; OBESITY; HEALTH;
   TISSUE; INFLAMMATION
AB Background Visceral adipose tissue (VAT) accumulation is a major cardiometabolic risk factor, associated with increased inflammation. Oxidative stress (OS) is also associated with inflammation and cardiometabolic issues, yet mainly through general obesity. Both OS and obesity were linked to vitamin D deficiency. Objectives To investigate whether OS increase is associated with VAT accumulation in youth, and whether in the presence of VAT accumulation, a higher vitamin D status is associated with lower OS. Methods One hundred and fifty-eight youth with overweight/obesity, 7 to 17 years old, were recruited (Pediatric Clinic, Luxembourg). We assessed visceral and subcutaneous abdominal adipose tissues by magnetic resonance imaging, OS by DNA/RNA oxidative damage with ELISA and vitamin D by high-performance liquid chromatography. Results VAT was the body fat compartment the most strongly associated with OS (R-Pearson: 0.298;P< 10(-4)). The general linear (GLM) models assessing the relationship between OS, VAT and vitamin D concentrations showed that "Log(10)OS = (0.003 x VAT) + 3.911 (R-adjusted(2): 0.083;P-value < 10(-4))"; "Log(10)OS = (0.003 x VAT) - (0.156 x log(10)vitamin D) + 4.110 (R-adjusted(2): 0.101;P-value < 10(-4))". After back-transformation of the log-values into normal values, the GLM showed that, for a person with an average value of VAT (40.7 cm(2)), a 10 cm(2)increase in VAT would increase OS by approx. 771.833 pg/mL, after age, gender, Tanner stage and physical activity adjustment. An approximate increase of 9 ng/mL of vitamin D would counterbalance this negative effect of increased VAT. Conclusion Dietary strategies improving vitamin D status should be investigated to tackle VAT and OS increase.
C1 [Samouda, Hanen; Bohn, Torsten] Luxembourg Inst Hlth, Dept Populat Hlth, Nutr & Hlth Res Grp, Strassen, Luxembourg.
   [De Beaufort, Carine; Ghaddhab, Chiraz] Ctr Hosp Luxembourg, Diabet & Endocrinol Care Clin Pediat, Luxembourg, Luxembourg.
   [Gilson, Georges] Ctr Hosp Luxembourg, Dept Clin Biol, Luxembourg, Luxembourg.
   [Schritz, Anna; Vaillant, Michel] Luxembourg Inst Hlth, Competence Ctr Methodol & Stat, Strassen, Luxembourg.
   [Ruiz-Castell, Maria; Huiart, Laetitia] Luxembourg Inst Hlth, Dept Populat Hlth, Strassen, Luxembourg.
   [Dohet, Francois; Weber, Bernard] Labs Reunis, Junglinster, Luxembourg.
C3 Luxembourg Institute of Health; Luxembourg Hospital Center; Luxembourg
   Hospital Center; Luxembourg Institute of Health; Luxembourg Institute of
   Health
RP Samouda, H (corresponding author), Luxembourg Inst Hlth, Populat Hlth Dept, Nutr & Hlth Res Grp, 1A,Rue Thomas Edison, L-1445 Strassen, Luxembourg.
EM hanene.samouda@lih.lu
RI Bohn, Torsten/AAE-8393-2019; Bustamante, Mariona/ABB-9142-2021;
   vaillant, michel/H-5635-2019; de Beaufort, Carine/AAJ-8063-2021;
   Schritz, Anna/K-8887-2019; Huiart, Laetitia/LXA-7410-2024
OI vaillant, michel/0000-0003-4714-8128; Bohn, Torsten/0000-0002-7825-0697;
   de Beaufort, Carine/0000-0003-4310-6799; Ruiz-Castell,
   Maria/0000-0001-9741-7491; Samouda, Hanen/0000-0003-3450-4189; Schritz,
   Anna/0000-0002-8478-8055
FU Fonds National de la Recherche Luxembourg; Luxembourg institute of
   Health; Ministry for Higher Education and Research, Luxembourg
FX Fonds National de la Recherche Luxembourg; Luxembourg institute of
   Health; Ministry for Higher Education and Research, Luxembourg
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NR 54
TC 11
Z9 11
U1 0
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1399-543X
EI 1399-5448
J9 PEDIATR DIABETES
JI Pediatr. Diabetes
PD AUG
PY 2020
VL 21
IS 5
BP 758
EP 765
DI 10.1111/pedi.13055
EA JUN 2020
PG 8
WC Endocrinology & Metabolism; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Pediatrics
GA MG9RH
UT WOS:000539645600001
PM 32418334
OA gold
DA 2025-06-11
ER

PT J
AU Orqueda, ME
   Zampini, IC
   Torres, S
   Alberto, MR
   Ramos, LLP
   Schmeda-Hirschmann, G
   Isla, MI
AF Eugenia Orqueda, Maria
   Catiana Zampini, Iris
   Torres, Sebastian
   Rosa Alberto, Maria
   Pino Ramos, Liudis Leidy
   Schmeda-Hirschmann, Guillermo
   Ines Isla, Maria
TI Chemical and functional characterization of skin, pulp and seed powder
   from the Argentine native fruit mistol (Ziziphus mistol). Effects
   of phenolic fractions on key enzymes involved in metabolic syndrome and
   oxidative stress
SO JOURNAL OF FUNCTIONAL FOODS
LA English
DT Article
DE Ziziphus mistol; Mistol fruit; Skin, pulp and seeds powder; Antioxidant
   capacity; Metabolic syndrome
ID ZIZYPHUS-MISTOL; GEOFFROEA-DECORTICANS; ANTIOXIDANT ACTIVITY;
   PROSOPIS-ALBA; ZIZIPHUS; FLAVONOIDS; L.; HEALTH; FLOUR; ACID
AB The mistol (Ziziphus mistol) is a native food tree occurring in dry areas of Northwestern and Central Argentina. Studies on its functional properties and bioactive compounds are scarce so far. In this work we assess the nutritional and functional components of lyophilized powder of mistol skin, pulp and seed. The powder from the different fruit parts have moderate carbohydrate content and are an important source of flavonoids, fiber, potassium, magnesium and calcium. The HPLC-ESI-MS/MS analysis of the polyphenols enriched extracts (PEE) of the samples allowed the identification of 17 compounds including 16 flavonoids and a procyanidin. The PEE showed antioxidant capacity and were able to inhibit alpha-glucosidase, alpha-amylase and pancreatic lipase, enzymes related to metabolic syndrome. The results suggest potential of the lyophilized skin, pulp and seed powder from mistol as functional food or dietary supplement in the prevention or treatment of diseases associated with metabolic syndrome. (C) 2017 Elsevier Ltd. All rights reserved.
C1 [Eugenia Orqueda, Maria; Catiana Zampini, Iris; Torres, Sebastian; Rosa Alberto, Maria; Ines Isla, Maria] Univ Nacl Tucuman, Fac Ciencias Nat, Inst Bioprospecc & Fisiol Vegetal INBIOFIV CONICE, Lab Invest Prod Nat LIPRON, San Miguel De Tucuman, Tucuman, Argentina.
   [Eugenia Orqueda, Maria; Catiana Zampini, Iris; Torres, Sebastian; Rosa Alberto, Maria; Ines Isla, Maria] Univ Nacl Tucuman, Inst Miguel Lillo, San Miguel De Tucuman, Tucuman, Argentina.
   [Pino Ramos, Liudis Leidy; Schmeda-Hirschmann, Guillermo] Univ Talca, Inst Quim Recursos Nat, Lab Quim Prod Nat, Casilla 747, Talca 3460000, Chile.
C3 Universidad Nacional de Tucuman; Universidad Nacional de Tucuman; Miguel
   Lillo Foundation; Universidad de Talca
RP Isla, MI (corresponding author), Univ Nacl Tucuman, INBIOFIV CONICET, San Lorenzo 1469, RA-4000 San Miguel De Tucuman, Tucuman, Argentina.
EM eorqueda@yahoo.com.ar; zampini@csnat.unt.edu.ar; sebatk@hotmail.com;
   mralberto@csnat.unt.edu.ar; lipino@utalca.cl; schmeda@utalca.cl;
   misla@tucbbs.com.ar
RI Torres, Sebastian/AAE-4510-2020; Alberto, Maria Rosa/AAS-3062-2021;
   Schmeda Hirschmann, Guillermo/G-1046-2010
OI Alberto, Maria Rosa/0000-0002-4173-9499; Schmeda Hirschmann,
   Guillermo/0000-0002-9228-5378; Pino, Liudis/0000-0002-3917-6703; TORRES,
   Sebastian/0000-0002-3593-831X
FU Secretaria de Ciencia, Arte e Innovation Tecnologica de la Universidad
   Nacional de Tucuman, Argentina (SCAIT-UNT); Consejo Nacional de
   InvestigacionesCienti ficas y Tecnicas, Argentina (CONICET); Agenda
   Nacional de Promocion Cientlfica y Tecnologica (ANPCyT); FONDECYT
   (Chile) [1120096]; PIEI-QUIM-BIO, Universidad de Talca
FX This research was supported by Secretaria de Ciencia, Arte e Innovation
   Tecnologica de la Universidad Nacional de Tucuman, Argentina
   (SCAIT-UNT), Consejo Nacional de InvestigacionesCienti ficas y Tecnicas,
   Argentina (CONICET), Agenda Nacional de Promocion Cientlfica y
   Tecnologica (ANPCyT), FONDECYT 1120096 (Chile) and PIEI-QUIM-BIO,
   Universidad de Talca.
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NR 55
TC 25
Z9 25
U1 1
U2 15
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1756-4646
EI 2214-9414
J9 J FUNCT FOODS
JI J. Funct. Food.
PD OCT
PY 2017
VL 37
BP 531
EP 540
DI 10.1016/j.jff.2017.08.020
PG 10
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA FJ6JF
UT WOS:000412863400054
OA Green Published
DA 2025-06-11
ER

PT J
AU Leyva-Soto, A
   Chavez-Santoscoy, RA
   Porras, O
   Hidalgo-Ledesma, M
   Serrano-Medina, A
   Ramírez-Rodríguez, AA
   Castillo-Martinez, NA
AF Leyva-Soto, Aldo
   Chavez-Santoscoy, Rocio Alejandra
   Porras, Omar
   Hidalgo-Ledesma, Miltha
   Serrano-Medina, Aracely
   Ramirez-Rodriguez, Ana Alejandra
   Castillo-Martinez, Nydia Alejandra
TI Epicatechin and quercetin exhibit in vitro antioxidant effect, improve
   biochemical parameters related to metabolic syndrome, and decrease
   cellular genotoxicity in humans
SO FOOD RESEARCH INTERNATIONAL
LA English
DT Article
DE Enriched bread; (?)-epicatechin; HyPer; Metabolic syndrome; Quercetin;
   Genoprotective effect
AB Metabolic syndrome is a condition whose incidence has been increasing around the world. It promotes a metabolic state of chronic systemic inflammation, correlated to cellular stress and genetic mutations, and subsequently with deadly chronic diseases, such as type 2 diabetes mellitus, cardiovascular diseases, and cancer. A randomized placebo-controlled study (n = 156) was conducted to determine the effects of consuming an enriched bread with 0.05% of a 1:1 mixture of (-)-epicatechin and quercetin on anthropometric and biochemical parameters of the participants. As a result, total cholesterol, LDL-cholesterol, total triglycerides, and fasting plasma glucose significantly decreased after three months of daily enriched bread consumption. Nuclear abnormalities in buccal epithelium cells also decreased (15.8 ? 3.2 down to 8.3 ? 1.0), showing a genoprotective effect. The antioxidant properties of these compounds were observed by monitoring changes in the cytoplasmic redox tone of intact Caco-2 cells expressing HyPer, a fluorescent redox biosensor. The combination of (?)-epicatechin and quercetin changes the cytoplasmic redox ambient in living cells and significantly improves biochemical parameters related to metabolic syndrome, and decreases the number of cell abnormalities in buccal epithelium cells of patients.
C1 [Leyva-Soto, Aldo; Ramirez-Rodriguez, Ana Alejandra] Univ Autonoma Baja Calif UABC, Fac Ciencias Quim & Ingn, Campus Tijuana,Calzada Univ 14418, Tijuana 22390, BC, Mexico.
   [Chavez-Santoscoy, Rocio Alejandra] Tecnol Monterrey, Ctr Biotecnol FEMSA, Escuela Ingn & Ciencias, Av Eugenio Garza Sada 2501 Sur, Monterrey 64849, NL, Mexico.
   [Porras, Omar; Hidalgo-Ledesma, Miltha] Univ Chile, Inst Nutr & Tecnol Alimentos INTA, Lab Res Funct Nutr, Santiago, Chile.
   [Serrano-Medina, Aracely] Univ Autonoma Baja Calif UABC, Fac Med & Psicol, Campus Tijuana,Calzada Univ 14418, Tijuana 22390, BC, Mexico.
   [Castillo-Martinez, Nydia Alejandra] Univ Autonoma Baja California, Fac Ciencias Salud, Blvd Univ 1000, Tijuana 21500, BC, Mexico.
C3 Tecnologico de Monterrey; Universidad de Chile; Universidad Autonoma de
   Baja California
RP Chavez-Santoscoy, RA (corresponding author), Tecnol Monterrey, Ctr Biotecnol FEMSA, Escuela Ingn & Ciencias, Av Eugenio Garza Sada 2501 Sur, Monterrey 64849, NL, Mexico.
EM ale.santoscoy@gmail.com
RI Serrano-Medina, Aracely/AAV-2741-2021; Castillo-Martinez,
   Nydia-Alejandra/C-8828-2016; Chavez-Santoscoy, Rocio
   Alejandra/AAG-5643-2020; Porras, Omar/H-7913-2013
OI Leyva, Aldo/0000-0002-9811-8757; Castillo-Martinez,
   Nydia-Alejandra/0000-0002-7460-9228; Chavez-Santoscoy, Rocio
   Alejandra/0000-0002-4551-1862; Porras, Omar/0000-0001-6314-9345
FU Facultad de Ciencias Quimicas e Ingenieria, Universidad Autonoma de Baja
   California; CONACYT
FX The authors gratefully acknowledge the Facultad de Ciencias Quimicas e
   Ingenieria, Universidad Autonoma de Baja California, for the financing
   given to realize this project. Also, acknowledge CONACYT for a doctoral
   fellowship. We would also like to express our gratitude to the "Centro
   de Investigacion en Alimentos para el Bienestar en el Ciclo Vital,
   ABCVital" of INTA-Universidad de Chile. The authors thank Noemi Arellano
   Villasenor for technical support through the trial with participants.
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NR 38
TC 53
Z9 55
U1 2
U2 17
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0963-9969
EI 1873-7145
J9 FOOD RES INT
JI Food Res. Int.
PD APR
PY 2021
VL 142
AR 110101
DI 10.1016/j.foodres.2020.110101
EA FEB 2021
PG 8
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA RG4RT
UT WOS:000635528300011
PM 33773697
DA 2025-06-11
ER

PT J
AU Ali, SS
   Oni, ET
   Blaha, MJ
   Veledar, E
   Feiz, HR
   Feldman, T
   Agatston, AS
   Blumenthal, RS
   Conceicao, RD
   Carvalho, JAM
   Santos, RD
   Nasir, K
AF Ali, Shozab S.
   Oni, Ebenezer T.
   Blaha, Michael J.
   Veledar, Emir
   Feiz, Hamid R.
   Feldman, Theodore
   Agatston, Arthur S.
   Blumenthal, Roger S.
   Conceicao, Raquel D.
   Carvalho, Jose A. M.
   Santos, Raul D.
   Nasir, Khurram
TI Elevated gamma-glutamyl transferase is associated with subclinical
   inflammation independent of cardiometabolic risk factors in an
   asymptomatic population: a cross-sectional study
SO NUTRITION & METABOLISM
LA English
DT Article
DE Gamma-glutamyl transferase; C-reactive protein; Subclinical inflammation
ID C-REACTIVE PROTEIN; METABOLIC SYNDROME; CARDIOVASCULAR-DISEASE;
   FOLLOW-UP; HEPATIC STEATOSIS; OXIDATIVE STRESS; BLOOD-PRESSURE;
   HEALTHY-MEN; ATHEROSCLEROSIS; GLUTAMYLTRANSFERASE
AB Background: Serum Gamma-Glutamyl Transferase (GGT), a marker of oxidative stress, has been suggested to be independently associated with cardiovascular disease (CVD) events. We examined the association of serum GGT levels with the burden of subclinical inflammation across a spectrum of metabolic conditions.
   Methods: We evaluated 5,446 asymptomatic subjects (43 +/- 10 years, 78 % males) who had an employer-sponsored physical between 2008 and 2010. Highly sensitivity C-reactive protein (hsCRP) was measured as a marker of underlying systemic inflammation. A linear regression of GGT quartiles with log transformed hsCRP and a multivariate logistic regression of GGT quartiles with elevated hsCRP (>= 3 mg/L) were performed.
   Results: Median GGT was 31 IU/l (IQR: 22-45 IU/l), 1025 (19 %) had hsCRP >= 3 mg/L. The median hsCRP increased with GGT quartiles (Q1: 0.9 mg/L, Q2: 1.1 mg/L, Q3: 1.4 mg/L, Q4: 1.6 mg/L, p < 0.001). Linear regression models showed GGT in the fourth quartile was associated with 0.45 mg/L (95 % CI 0.35, 0.54, p < 0.001) increase in log transformed hsCRP adjusting for risk factors. The Odds Ratio (OR) for an elevated hsCRP (>= 3 mg/L) also increased with higher GGT quartiles; GGT Q2 1.44 (95 % CI 1.12, 1.85), GGT Q3 1.89 (95 % CI 1.45, 2.46), GGT Q4 2.22 (95 % CI 1.67, 2.95), compared to GGT Q1. The strength of association increased in the presence of and combination of metabolic conditions.
   Conclusion: In our cohort of asymptomatic individuals a higher serum GGT level was independently associated with increased burden of subclinical inflammation across metabolic states. These findings may explain GGT association with increased CVD risk.
C1 [Ali, Shozab S.; Oni, Ebenezer T.; Veledar, Emir; Feldman, Theodore; Agatston, Arthur S.; Nasir, Khurram] Baptist Hlth Med Grp, Ctr Healthcare Adv & Outcomes, 1691 Michigan Ave Suite 500, Miami, FL 33139 USA.
   [Ali, Shozab S.] Univ Manchester, Sch Med, Manchester, Lancs, England.
   [Ali, Shozab S.; Feiz, Hamid R.] Aventura Hosp & Med Ctr, Aventura, FL USA.
   [Oni, Ebenezer T.] Icahn Sch Med Mt Sinai, Brooklyn Hosp Ctr, Dept Med, Brooklyn, NY USA.
   [Blaha, Michael J.; Blumenthal, Roger S.; Nasir, Khurram] Johns Hopkins Univ, Johns Hopkins Ciccarone Ctr Prevent Heart Dis, Baltimore, MD USA.
   [Conceicao, Raquel D.; Carvalho, Jose A. M.; Santos, Raul D.] Hosp Israelita Albert Einstein, Prevent Med Ctr, Sao Paulo, Brazil.
   [Santos, Raul D.] Univ Sao Paulo, Sch Med, Lipid Clin Heart Inst InCor, Sao Paulo, Brazil.
   [Nasir, Khurram] Florida Int Univ, Robert Stempel Coll Publ Hlth, Miami, FL 33199 USA.
   [Nasir, Khurram] Florida Int Univ, Herbert Wertheim Coll Med, Miami, FL 33199 USA.
C3 University of Manchester; Brooklyn Hospital Center; Icahn School of
   Medicine at Mount Sinai; Johns Hopkins University; Johns Hopkins
   Medicine; Hospital Israelita Albert Einstein; Universidade de Sao Paulo;
   State University System of Florida; Florida International University;
   State University System of Florida; Florida International University
RP Nasir, K (corresponding author), Baptist Hlth Med Grp, Ctr Healthcare Adv & Outcomes, 1691 Michigan Ave Suite 500, Miami, FL 33139 USA.; Nasir, K (corresponding author), Johns Hopkins Univ, Johns Hopkins Ciccarone Ctr Prevent Heart Dis, Baltimore, MD USA.
EM KhurramN@baptisthealth.net
RI Veledar, Emir/L-6637-2019; Santos, Raul/A-1170-2010; Nasir,
   Khurram/A-2317-2008; Blumenthal, Roger/H-3223-2018
OI Veledar, Emir/0000-0002-3831-5433
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NR 33
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U1 0
U2 4
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1743-7075
J9 NUTR METAB
JI Nutr. Metab.
PD MAY 18
PY 2016
VL 13
AR 37
DI 10.1186/s12986-016-0097-7
PG 7
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA DM9GL
UT WOS:000376673000001
PM 27195017
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Wang, SP
   Zhang, B
   Chang, XT
   Zhao, HL
   Zhang, HJ
   Zhao, TT
   Qi, HM
AF Wang, Shaopeng
   Zhang, Bo
   Chang, Xintao
   Zhao, Hailing
   Zhang, Haojun
   Zhao, Tingting
   Qi, Huimin
TI Potential use of seaweed polysaccharides as prebiotics for management of
   metabolic syndrome: a review
SO CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
LA English
DT Review
DE Gut microbiota; metabolic syndrome; prebiotics; seaweed polysaccharides;
   short-chain fatty acids
ID DIET-INDUCED OBESITY; HUMAN GUT MICROBIOME; BILE-ACIDS; BROWN-ALGAE;
   SULFATED POLYSACCHARIDES; AKKERMANSIA-MUCINIPHILA; MARINE
   POLYSACCHARIDES; GROWTH-PERFORMANCE; MOLECULAR-WEIGHT; FIBER INTAKE
AB Seaweed polysaccharides (SPs) obtained from seaweeds are a class of functional prebiotics. SPs can regulate glucose and lipid anomalies, affect appetite, reduce inflammation and oxidative stress, and therefore have great potential for managing metabolic syndrome (MetS). SPs are poorly digested by the human gastrointestinal tract but are available to the gut microbiota to produce metabolites and exert a series of positive effects, which may be the mechanism by which SPs render their anti-MetS effects. This article reviews the potential of SPs as prebiotics in the management of MetS-related metabolic disturbances. The structure of SPs and studies related to the process of their degradation by gut bacteria and their therapeutic effects on MetS are highlighted. In summary, this review provides new perspectives on SPs as prebiotics to prevent and treat MetS.
C1 [Wang, Shaopeng; Qi, Huimin] Weifang Med Univ, Coll Pharm, Weifang, Shandong, Peoples R China.
   [Wang, Shaopeng; Zhang, Bo; Zhao, Hailing; Zhang, Haojun; Zhao, Tingting] China Japan Friendship Hosp, Inst Clin Med Sci, Beijing Key Lab Immune Mediated Inflammatory Dis, Beijing, Peoples R China.
   [Chang, Xintao] Peoples Hosp Zhangqiu Dist, Dept Pharm, Jinan, Shandong, Peoples R China.
C3 Shandong Second Medical University; China-Japan Friendship Hospital
RP Qi, HM (corresponding author), Weifang Med Univ, Coll Pharm, Weifang, Shandong, Peoples R China.; Zhao, TT (corresponding author), China Japan Friendship Hosp, Inst Clin Med Sci, Beijing Key Lab Immune Mediated Inflammatory Dis, Beijing, Peoples R China.
EM ttfrfr@163.com; wfqihuimin@163.com
RI zhang, zhilong/JHS-5747-2023; zhang, shaomin/AAL-9674-2020
OI Wang, Shaopeng/0000-0001-8161-5178
FU National High Level Hospital Clinical Research Funding
   [2022-NHLHCRF-py-06]; National Natural Science Foundation of China
   [41206129, 81973627]; Natural Science Foundation of Shandong Province
   [ZR2022MD058, ZR2020MD094]; Beijing Natural Science Foundation
   [7212195]; Weifang Medical University Teachers Domestic Scholar Program
FX AcknowledgementsThis work was supported by the National High Level
   Hospital Clinical Research Funding [grant number 2022-NHLHCRF-py-06];
   National Natural Science Foundation of China [grant number 41206129,
   81973627]; Natural Science Foundation of Shandong Province [grant number
   ZR2022MD058; ZR2020MD094]; and Beijing Natural Science Foundation [grant
   number 7212195], and Weifang Medical University Teachers Domestic
   Scholar Program. The authors thank Nissi S. Wang, MSc, for developmental
   editing of the manuscript.
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NR 248
TC 6
Z9 7
U1 13
U2 69
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1040-8398
EI 1549-7852
J9 CRIT REV FOOD SCI
JI Crit. Rev. Food Sci. Nutr.
PD AUG 28
PY 2024
VL 64
IS 22
BP 7707
EP 7727
DI 10.1080/10408398.2023.2191135
EA MAR 2023
PG 21
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA E5P3S
UT WOS:001023083600001
PM 36971135
DA 2025-06-11
ER

PT J
AU Xu, XH
   Ren, J
AF Xu, Xihui
   Ren, Jun
TI Cardiac Stem Cell Regeneration in Metabolic Syndrome
SO CURRENT PHARMACEUTICAL DESIGN
LA English
DT Article
DE Metabolic syndrome; obesity; diabetes; heart; stem cell; cell
   regeneration
ID SIDE POPULATION CELLS; NUTRITION EXAMINATION SURVEY; 3RD
   NATIONAL-HEALTH; MYOCARDIAL REGENERATION; OXIDATIVE STRESS;
   CARDIOVASCULAR-DISEASE; DIABETES-MELLITUS; PROGENITOR CELLS;
   HEART-FAILURE; CONTRACTILE DYSFUNCTION
AB The metabolic syndrome (MetS) is a constellation of multiple metabolic risk factors including obesity, glucose intolerance, insulin resistance, dyslipidemia and hypertension. Individuals with MetS are found to be afflicted with an increased risk of type 2 diabetes mellitus and overall cardiovascular diseases. One of the common comorbidities of MetS is the impairment of heart function en route to loss of cardiomyocytes and ultimately heart failure. Although it is accepted that cardiomyocytes are terminally differentiated, recent evidence has challenged this concept to indicate the ability of cardiomyocytes to regenerate from progenitor cells of the heart and other organs. Moreover, it has been suggested that pathological conditions such as MetS may play a role in the regulation of cardiomyocyte regeneration. This mini-review will discuss the role of MetS in the regulatory machineries of cardiomyocyte regeneration.
C1 [Xu, Xihui; Ren, Jun] Univ Wyoming, Coll Hlth Sci, Ctr Cardiovasc Res & Alternat Med, Laramie, WY 82071 USA.
C3 University of Wyoming
RP Ren, J (corresponding author), Univ Wyoming, Sch Pharm, Laramie, WY 82071 USA.
EM jren@uwyo.edu
RI Xu, Xihui/C-2017-2014; Ren, Jun/ACG-5366-2022
OI Ren, Jun/0000-0002-0275-0783
FU NIH/NCRR [5P20RR016474]
FX NIH/NCRR 5P20RR016474.
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NR 61
TC 5
Z9 6
U1 0
U2 10
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1381-6128
EI 1873-4286
J9 CURR PHARM DESIGN
JI Curr. Pharm. Design
PD AUG
PY 2013
VL 19
IS 27
BP 4888
EP 4892
DI 10.2174/1381612811319270011
PG 5
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 172ZA
UT WOS:000321045100011
PM 23323616
DA 2025-06-11
ER

PT J
AU Mahdavi-Roshan, M
   Shoaibinobarian, N
   Evazalipour, M
   Salari, A
   Ghorbani, Z
   Savarrakhsh, A
   Ahmadnia, Z
AF Mahdavi-Roshan, Marjan
   Shoaibinobarian, Nargeskhatoon
   Evazalipour, Mehdi
   Salari, Arsalan
   Ghorbani, Zeinab
   Savarrakhsh, Amir
   Ahmadnia, Zahra
TI An open label randomized controlled trial of the effects of rice bran
   oil on cardiometabolic risk factors, lipid peroxidation and antioxidant
   status in overweight/obese adults with metabolic syndrome
SO LIPIDS IN HEALTH AND DISEASE
LA English
DT Article
DE Antioxidant; Glycemia; Lipid profile; Metabolic factors; Oxidative
   stress; RBO
ID INSULIN-RESISTANCE; DIABETES-MELLITUS; CARDIOVASCULAR-DISEASE;
   GAMMA-ORYZANOL; CANOLA OIL; CHOLESTEROL; IMPROVES; BLIND; DIET;
   INFLAMMATION
AB Introduction We previously documented the beneficial effects of rice bran oil (RBO) on cardiac function and atherogenic cardiometabolic factors in men with coronary artery disease. Therefore, the existing evidence in this area aims to be expanded by investigating the impact of adding RBO to a daily standard diet on emerging insulin resistance surrogate markers, lipid peroxidation, antioxidant status, and metabolic disturbances in individuals with metabolic syndrome (MetSyn) through an open-label controlled trial. Methods A total of 50 overweight/obese adults (mean body mass index (BMI) = 31.08 kg/m2) with at least 3 MetSyn components were randomly allocated to either the control group, which received a standard diet plan, or the intervention group, which was supplemented with 30 g/d RBO for 8 weeks. BMI, MetSyn components, metabolic score for insulin resistance (METS-IR), triglyceride-glucose-BMI (TyG-BMI), malondialdehyde (MDA), total antioxidant capacity (TAC), and plasma polyphenol levels were measured before and after this open-label trial. Results Analysis of covariance (ANCOVA) adjusted for baseline values revealed that, compared with patients who received only a standard diet, those who were supplemented with 30 g/d RBO presented significantly lower total cholesterol (P value = 0.005; effect size (ES):-0.92), LDL-cholesterol (P value = 0.048; ES:-0.62), fasting blood glucose (P value = 0.014; ES:-0.77), MDA (P value = 0.002; ES: -1.01), METS-IR (P value < 0.001; ES: -1.24), and TyG-BMI (P value = 0.007; ES:-0.85) after 8 weeks. Additionally, RBO consumption resulted in significantly higher levels of HDL-C (P value = 0.004; ES:0.94) and TAC (P value < 0.0001; ES:2.05). However, no significant changes were noted in BMI, waist circumference, serum triglycerides, plasma polyphenols, or blood pressure. Conclusion Although the current findings suggest that the hypocholesterolemic, antihyperglycemic, and antioxidative effects of 30 g/d RBO seem to be promising for MetSyn patients, they should be considered preliminary. Therefore, further well-designed clinical trials with larger sample sizes and longer durations are needed to confirm these findings.
C1 [Mahdavi-Roshan, Marjan; Shoaibinobarian, Nargeskhatoon; Salari, Arsalan; Ghorbani, Zeinab; Savarrakhsh, Amir; Ahmadnia, Zahra] Guilan Univ Med Sci, Cardiovasc Dis Res Ctr, Sch Med, Dept Cardiol,Heshmat Hosp, Rasht, Iran.
   [Mahdavi-Roshan, Marjan; Ghorbani, Zeinab] Guilan Univ Med Sci, Sch Med, Dept Clin Nutr, Rasht, Iran.
   [Shoaibinobarian, Nargeskhatoon] Islamic Azad Univ, Sch Med Sci & Technol, Dept Nutr, Sci & Res Branch, Tehran, Iran.
   [Evazalipour, Mehdi] Guilan Univ Med Sci, Sch Pharm, Dept Pharmaceut Biotechnol, Rasht, Iran.
C3 Guilan University of Medical Sciences; Guilan University of Medical
   Sciences; Islamic Azad University; Guilan University of Medical Sciences
RP Mahdavi-Roshan, M; Ghorbani, Z (corresponding author), Guilan Univ Med Sci, Cardiovasc Dis Res Ctr, Sch Med, Dept Cardiol,Heshmat Hosp, Rasht, Iran.; Mahdavi-Roshan, M; Ghorbani, Z (corresponding author), Guilan Univ Med Sci, Sch Med, Dept Clin Nutr, Rasht, Iran.
EM marjanmahdavi60@gmail.com; z.ghorbani.h@gmail.com
RI Mahdavi-Roshan, Marjan/H-1444-2017; Evazalipour, Mehdi/I-5081-2017;
   Salari, Arsalan/D-2855-2019; ghorbani, zeinab/AAF-5343-2021
FU Guilan University of Medical Sciences (GUMS), Rasht, Iran [3733, 71214]
FX This study was financially supported by Guilan University of Medical
   Sciences (GUMS), Rasht, Iran (research code = 3733; 71214).
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NR 60
TC 2
Z9 2
U1 2
U2 3
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1476-511X
J9 LIPIDS HEALTH DIS
JI Lipids Health Dis.
PD AUG 28
PY 2024
VL 23
IS 1
AR 273
DI 10.1186/s12944-024-02260-4
PG 14
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA E1M4H
UT WOS:001300716000005
PM 39198792
OA gold
DA 2025-06-11
ER

PT J
AU Chaborski, K
   Bitterlich, N
   Alteheld, B
   Parsi, E
   Metzner, C
AF Chaborski, Katrin
   Bitterlich, Norman
   Alteheld, Birgit
   Parsi, Elke
   Metzner, Christine
TI Placebo-controlled dietary intervention of stress-induced
   neurovegetative disorders with a specific amino acid composition: a
   pilot-study
SO NUTRITION JOURNAL
LA English
DT Article
DE Psychosocial stress; Hypothalamus-Pituitary-Adrenal (HPA)-axis;
   Sympathetic nervous system (SN); Amino acid composition; Dietary
   supplement; Psychological Neurological Questionnaire (PNF)
ID MAGNESIUM-DEFICIENCY; FOOD-INTAKE; FAT; BRAIN; SUPPLEMENTATION;
   ENHANCEMENT; AGGRESSION; RESPONSES; ANXIETY; MOOD
AB Background: Psychosocial stress leads to altered neuroendocrine functions, such as serotonergic dysfunction, as well as alterations of the autonomic nervous system and the hypothalamic-pituitary-adrenal (HPA)-axis activity resulting in an imbalance between inhibitory and excitatory neurotransmitters. Poor dietary intake of L-tryptophan as a precursor of serotonin increases sensitivity to stress.
   Methods: This randomized, double-blind, placebo-controlled study investigated the effect of a specific amino acid composition with micronutrients on neurovegetative disorders and the cardiometabolic risk profile in psychosocially stressed patients. 32 patients (18-65 years) were eligible for protocol analysis. Points in the Psychological Neurological Questionnaire (PNF), clinical and blood parameter, in particular the serotonin level, salivary cortisol levels, and dietary intake were evaluated at baseline and 12 weeks after supplementation.
   Results: The intervention in the form of either verum or placebo resulted in both groups in a significant decrease of neurovegetative symptoms. However, patients of the placebo group achieved significantly less points in the PNF compared to the verum group. But the rate of responders (>= 10 points loss in PNF) was not significantly different between the groups. The macronutrient intake did not differ between verum and placebo group. On average, the HPA-axis was not disturbed in both groups. Blood serotonin indicated in both groups no significant correlation with dietary tryptophan intake or PNF.
   Conclusions: Daily supplementation of a specific amino acid composition with micronutrients in psychologically stressed patients resulted in no improvement of neurovegetative disorders as measured by the PNF when compared to the placebo group.
C1 [Chaborski, Katrin; Alteheld, Birgit] Univ Bonn, Dept Nutr & Food Sci, Nutr Physiol, D-53115 Bonn, Germany.
   [Bitterlich, Norman] Med & Serv Ltd, Dept Biostat, D-09117 Chemnitz, Germany.
   [Parsi, Elke] Outpatient Practice Cardiol Angiol, D-13053 Berlin, Germany.
   [Metzner, Christine] Rhein Westfal TH Aachen, Univ Hosp, Dept Internal Med 3, D-52074 Aachen, Germany.
   [Metzner, Christine] Bonn Educ Assoc Dietet rA, D-50935 Cologne, Germany.
C3 University of Bonn; RWTH Aachen University; RWTH Aachen University
   Hospital
RP Metzner, C (corresponding author), Rhein Westfal TH Aachen, Univ Hosp, Dept Internal Med 3, Pauwelsstr 44, D-52074 Aachen, Germany.
EM christine.metzner@rwth-aachen.de
FU Kyberg Vital GmbH, Unterhaching, Germany
FX Kyberg Vital GmbH, Unterhaching, Germany.
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NR 41
TC 3
Z9 7
U1 0
U2 9
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1475-2891
J9 NUTR J
JI Nutr. J.
PD MAY 6
PY 2015
VL 14
AR 43
DI 10.1186/s12937-015-0030-3
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA CH9JV
UT WOS:000354352800001
PM 25943490
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Liu, R
   Chen, L
   Wang, Y
   Zhang, GF
   Cheng, Y
   Feng, ZH
   Bai, XC
   Liu, JK
AF Liu, Run
   Chen, Lei
   Wang, Yan
   Zhang, Guanfei
   Cheng, Ying
   Feng, Zhihui
   Bai, Xiaochun
   Liu, Jiankang
TI High ratio of ω-3/ω-6 polyunsaturated fatty acids targets mTORC1 to
   prevent high-fat diet-induced metabolic syndrome and mitochondrial
   dysfunction in mice
SO JOURNAL OF NUTRITIONAL BIOCHEMISTRY
LA English
DT Article
DE omega-3 PUFAs; mTORC1; Mitochondrial function; Metabolic syndrome; TCA
   cycle
ID CARDIOVASCULAR-DISEASE; INSULIN SENSITIVITY; GLUCOSE-INTOLERANCE;
   OMEGA-3-FATTY-ACIDS; OMEGA-3; DEFICIENCY; PUFA
AB Adjusting omega-3/omega-6 polyunsaturated fatty acids (PUFAs) ratio in high-fat diet is one potential mean to improve metabolic syndrome; however, underlying mechanisms remain unclear. Four groups of mice were fed 60% kcal diets with saturated fatty acids, three different omega-3/omega-6 PUFAs ratios (low, middle and high) for 12 weeks, respectively. Body weight, atherosclerosis marker, insulin signal index and level of lipid accumulation in liver were significantly lowered in High group compared with saturated fatty acids group and Low group at week 12. Expressions of p-mTOR and raptor were inhibited by high omega-3 PUFAs. Importantly, omega-3 PUFAs intake up-regulated mitochondrial electron transport chain and tricarboxylic acid cycle pathway through metabolomics analysis in liver. Mitochondrial complexes activities were raised, fumaric acid was reduced and oxidative stress was alleviated in High group. We conclude that consuming long-term high-fat diet with same calories but high omega-3/omega-6 PUFAs ratio relieves metabolic syndrome by regulating mTORC1 pathway to enhance mitochondrial function. (C) 2020 Elsevier Inc. All rights reserved.
C1 [Liu, Run; Chen, Lei; Wang, Yan; Zhang, Guanfei; Cheng, Ying; Feng, Zhihui; Liu, Jiankang] Xi An Jiao Tong Univ, Ctr Mitochondrial Biol & Med, Sch Life Sci & Technol, Key Lab Biomed Informat Engn,Minist Educ, Xian 710049, Peoples R China.
   [Bai, Xiaochun] Southern Med Univ, Sch Basic Med Sci, Dept Cell Biol, Guangzhou, Peoples R China.
C3 Ministry of Education - China; Xi'an Jiaotong University; Southern
   Medical University - China
RP Liu, JK (corresponding author), Xi An Jiao Tong Univ, Ctr Mitochondrial Biol & Med, Sch Life Sci & Technol, Key Lab Biomed Informat Engn,Minist Educ, Xian 710049, Peoples R China.
EM j.liu@mail.xjtu.edu.cn
RI Feng, Zhihui/E-7408-2011; cheng, yue/JAC-6644-2023; Liu,
   Jiankang/A-1610-2011
OI Liu, Run/0000-0002-2578-7941
FU National Basic Research Program [2015CB553602]; National Natural Science
   Foundation of China [31770917, 31570777, 91649106, 81571050]
FX This study was supported by the National Basic Research Program (973
   Project No. 2015CB553602) and the National Natural Science Foundation of
   China (Nos. 31770917, 31570777, 91649106 and 81571050).
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NR 45
TC 30
Z9 32
U1 4
U2 37
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0955-2863
EI 1873-4847
J9 J NUTR BIOCHEM
JI J. Nutr. Biochem.
PD MAY
PY 2020
VL 79
AR 108330
DI 10.1016/j.jnutbio.2019.108330
PG 10
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA LF3DD
UT WOS:000527300600005
PM 32179408
DA 2025-06-11
ER

PT J
AU Di Daniele, N
   Noce, A
   Vidiri, MF
   Moriconi, E
   Marrone, G
   Annicchiarico-Petruzzelli, M
   D'Urso, G
   Tesauro, M
   Rovella, V
   De Lorenzo, A
AF Di Daniele, Nicola
   Noce, Annalisa
   Vidiri, Maria Francesca
   Moriconi, Eleonora
   Marrone, Giulia
   Annicchiarico-Petruzzelli, Margherita
   D'Urso, Gabriele
   Tesauro, Manfredi
   Rovella, Valentina
   De Lorenzo, Antonino
TI Impact of Mediterranean diet on metabolic syndrome, cancer and longevity
SO ONCOTARGET
LA English
DT Review
DE Mediterranean diet; public health; obesity; cancer; antioxidant
ID CHRONIC KIDNEY-DISEASE; CARDIOVASCULAR RISK-FACTORS; BROWN
   ADIPOSE-TISSUE; BODY-MASS INDEX; GENE-NUTRIENT INTERACTIONS; TOTAL
   ANTIOXIDANT CAPACITY; CORONARY-HEART-DISEASE; LOW-PROTEIN DIET;
   NF-KAPPA-B; OXIDATIVE STRESS
AB Obesity symbolizes a major public health problem. Overweight and obesity are associated to the occurrence of the metabolic syndrome and to adipose tissue dysfunction. The adipose tissue is metabolically active and an endocrine organ, whose dysregulation causes a low-grade inflammatory state and ectopic fat depositions. The Mediterranean Diet represents a possible therapy for metabolic syndrome, preventing adiposopathy or "sick fat" formation.
   The Mediterranean Diet exerts protective effects in elderly subjects with and without baseline of chronic diseases. Recent studies have demonstrated a relationship between cancer and obesity. In the US, diet represents amount 30-35% of death causes related to cancer. Currently, the cancer is the second cause of death after cardiovascular diseases worldwide. Furthermore, populations living in the Mediterranean area have a decreased incidence of cancer compared with populations living in Northern Europe or the US, likely due to healthier dietary habits. The bioactive food components have a potential preventive action on cancer. The aims of this review are to evaluate the impact of Mediterranean Diet on onset, progression and regression of metabolic syndrome, cancer and on longevity.
C1 [Di Daniele, Nicola; Noce, Annalisa; Marrone, Giulia; D'Urso, Gabriele; Tesauro, Manfredi; Rovella, Valentina] Univ Roma Tor Vergata, Dept Syst Med, Hypertens & Nephrol Unit, Rome, Italy.
   [Vidiri, Maria Francesca; Moriconi, Eleonora; De Lorenzo, Antonino] Univ Roma Tor Vergata, Div Clin Nutr & Nutrigen, Dept Biomed & Prevent, Rome, Italy.
   [Annicchiarico-Petruzzelli, Margherita] Univ Roma Tor Vergata, Dept Expt Med & Surg, Biochem Lab, IDI IRCCS, Rome, Italy.
C3 University of Rome Tor Vergata; University of Rome Tor Vergata;
   University of Rome Tor Vergata; IRCCS Istituto Dermopatico
   dell'Immacolata (IDI)
RP Di Daniele, N; Noce, A (corresponding author), Univ Roma Tor Vergata, Dept Syst Med, Hypertens & Nephrol Unit, Rome, Italy.
EM didaniele@med.uniroma2.it; annalisa.noce@libero.it
RI Marrone, Giulia/IQR-7760-2023; Rovella, Valentina/AAB-9727-2019;
   Moriconi, Eleonora/AAS-2850-2020; Annicchiarico-Petruzzelli,
   Margherita/AAG-7746-2020; Noce, Annalisa/B-5558-2019; Stefanadis,
   Christodoulos/ABH-2232-2020
OI Marrone, Giulia/0000-0002-5854-2086; Stefanadis,
   Christodoulos/0000-0001-5974-6454; NOCE, ANNALISA/0000-0003-1310-3730;
   Moriconi, Eleonora/0000-0001-6395-4379; De Lorenzo,
   Antonino/0000-0001-6524-4493
FU Fondazione Roma
FX We would like to express gratitude to dr Eleonora Candi for critical
   reading of the manuscript. This work was supported by grants from
   Fondazione Roma.
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NR 291
TC 238
Z9 248
U1 3
U2 63
PU IMPACT JOURNALS LLC
PI ORCHARD PARK
PA 6666 E QUAKER ST, STE 1, ORCHARD PARK, NY 14127 USA
EI 1949-2553
J9 ONCOTARGET
JI Oncotarget
PD JAN 31
PY 2017
VL 8
IS 5
BP 8947
EP 8979
DI 10.18632/oncotarget.13553
PG 33
WC Oncology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Cell Biology
GA EJ5YP
UT WOS:000393295500149
PM 27894098
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Patil, AS
   Mahajan, UB
   Agrawal, YO
   Patil, KR
   Patil, CR
   Ojha, S
   Sharma, C
   Goyal, SN
AF Patil, Ashwani S.
   Mahajan, Umesh B.
   Agrawal, Yogeeta O.
   Patil, Kalpesh R.
   Patil, Chandragouda R.
   Ojha, Shreesh
   Sharma, Charu
   Goyal, Sameer N.
TI Plant-derived natural therapeutics targeting cannabinoid receptors in
   metabolic syndrome and its complications: A review
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Review
DE Endocannabinoids; Metabolic syndrome; Cannabinoid receptors;
   Plant-derived cannabinoids
ID FATTY LIVER-DISEASE; ENDOCANNABINOID SYSTEM; ADIPOSE-TISSUE; AGONIST;
   CANNABIDIOL; DRONABINOL; RIMONABANT; OBESITY; UPDATE; FUTURE
AB The endocannabinoid system (ECS) is natural physiological system in the humans. The presence of the ECS system involves different roles in body. The endocannabinoid system involves regulation of most of the centers, which regulates the hunger and leads to changes in the weight. In the present article, we reviewed the role of natural cannabinoid compounds in metabolic disorders and related complications. We studied variety of a plant -derived cannabinoids in treating the metabolic syndrome including stoutness, fatty acid liver diseases, insulin obstruction, dementia, hypertension, lipid abnormalities, non-alcoholic steatohepatitis, endothelial damage, and polycystic ovarian syndrome and so on. The activation of cannabinoid receptors demonstrates a significant number of beneficial approaches concerning metabolic syndrome and reduces the pro-inflammatory cytokines on account of aggravation, decreased oxidative stress and uneasiness, diminishes liver fibrosis, with reduces adiponectin. Pre-clinical investigations of plant-derived cannabinoids resulted in promising outcomes. The different distinctive plant-derived cannabinoids were discovered like cannabidiol (CBD), cannabinol (CBN), cannabichromene (CBC), and cannabidiol (CBG). It has been observed that endogenous cannabinoids and plant-derived cannabinoids have an advantageous impact on limiting the metabolic disorder arising due to lifestyle changes.
C1 [Patil, Ashwani S.; Mahajan, Umesh B.; Patil, Kalpesh R.; Patil, Chandragouda R.; Goyal, Sameer N.] RC Patel Inst Pharmaceut Educ & Res, Dept Pharmacol, Dhule 425405, Maharashtra, India.
   [Agrawal, Yogeeta O.] RC Patel Inst Pharmaceut Educ & Res, Dept Pharmaceut, Dhule 425405, Maharashtra, India.
   [Ojha, Shreesh] United Arab Emirates Univ, Coll Med & Hlth Sci, Dept Pharmacol & Therapeut, Al Ain 17666, U Arab Emirates.
   [Sharma, Charu] United Arab Emirates Univ, Coll Med & Hlth Sci, Dept Internal Med, Al Ain 17666, U Arab Emirates.
   [Goyal, Sameer N.] SVKMs Inst Pharm, Dhule 424001, Maharashtra, India.
C3 United Arab Emirates University; United Arab Emirates University
RP Goyal, SN (corresponding author), SVKMs Inst Pharm, Dhule 424001, Maharashtra, India.; Goyal, SN (corresponding author), RC Patel Inst Pharmaceut Educ & Res, Dept Pharmacol, Shirpur, Maharashtra, India.
EM goyal.aiims@gmail.com
RI Patil, Chandragouda/J-2235-2012; Mahajan, Umesh/I-5762-2019; Patil,
   Kalpesh/H-4173-2019
OI Patil, Ashwani/0000-0002-7127-2279; Patil,
   Chandragouda/0000-0001-8401-1978; OJHA, SHREESH/0000-0001-7801-2966;
   Goyal, sameer/0000-0002-5241-7049; Agrawal (Goyal),
   Yogeeta/0000-0002-3293-5607
FU Science and Engineering Research Board (SERB), Department of Science and
   Technology, New Delhi, India [EMR/2016/005106]; University Program for
   Advanced Research (UPAR), United Arab Emirates University, United Arab
   Emirates
FX The authors gratefully acknowledge the financial support received under
   Extra Mural Research (File no. EMR/2016/005106) of Science and
   Engineering Research Board (SERB), Department of Science and Technology,
   New Delhi, India. The authors also acknowledge the financial support to
   Dr. Shreesh Ojha received from University Program for Advanced Research
   (UPAR), United Arab Emirates University, United Arab Emirates.
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NR 76
TC 14
Z9 14
U1 0
U2 10
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD DEC
PY 2020
VL 132
AR 110889
DI 10.1016/j.biopha.2020.110889
PG 9
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA OU1VD
UT WOS:000591322000005
PM 33113429
OA gold
DA 2025-06-11
ER

PT J
AU Chen, BF
   Liu, L
   Lin, FZ
   Zeng, HM
   Huang, HQ
   Zhang, CF
   Liu, CC
   Chen, X
   Peng, J
   Wang, YF
   Wang, ZL
   Chen, B
   Liu, DL
   Liu, Y
   Li, ZZ
   Zeng, XX
AF Chen, Bo-Fan
   Liu, Li
   Lin, Fang-Zhen
   Zeng, Hai-Min
   Huang, Hai-Qiang
   Zhang, Chun-Fang
   Liu, Cong-Cong
   Chen, Xiang
   Peng, Jie
   Wang, Yun-Fa
   Wang, Zhi-Lin
   Chen, Bin
   Liu, De-Le
   Liu, Yun
   Li, Zheng-Zheng
   Zeng, Xin-Xing
TI Comprehensive bibliometric analysis of pharmacotherapy for bipolar
   disorders: Present trends and future directions
SO WORLD JOURNAL OF PSYCHIATRY
LA English
DT Article
DE Bipolar disorder; Drug treatment; Bibliometric analysis; Visualization;
   Mental disorder
ID II DISORDER; METABOLIC SYNDROME; SUICIDE ATTEMPTS; SCHIZOPHRENIA;
   DEPRESSION; LAMOTRIGINE; PREVALENCE; MECHANISMS; COMPONENTS; SCIENCE
AB BACKGROUND Bipolar disorder (BD) is a severe mental illness characterized by significant mood swings. Effective drug treatment modalities are crucial for managing BD. AIM To analyze the current status and future trends of global research on BD drug treatment over the last decade. METHODS The Web of Science Core Collection database spanning from 2015 to 2024 was utilized to retrieve literature related to BD drug treatment. A total of 2624 articles were extracted. Data visualization and analysis were conducted using CiteSpace, VOSviewer, Pajek, Scimago Graphica, and R-studio bibliometrix to identify research hotspots, key contributors, and future trends. RESULTS The United States, China, and the United Kingdom have made the most significant contributions to research on BD drug treatment and formed notable research collaboration networks. The University of Pittsburgh, Massachusetts General Hospital, and the University of Michigan have been identified as the major research institutions in this field. The Journal of Affective Disorders is the most influential journal. A keyword analysis revealed research hotspots related to clinical symptoms, drug efficacy, and genetic mechanisms. A citation analysis identified the management guidelines published by Yatham et al in 2018 as the most cited paper. CONCLUSION This study provides a detailed overview of the field of BD drug treatment, highlighting key contributors, research hotspots, and future directions. The study findings can be employed as a reference for future research and policymaking, which may enable further development and optimization of BD pharmacotherapy.
C1 [Chen, Bo-Fan; Liu, Li; Lin, Fang-Zhen; Zeng, Hai-Min; Huang, Hai-Qiang; Zhang, Chun-Fang; Liu, Cong-Cong; Peng, Jie; Wang, Yun-Fa; Wang, Zhi-Lin; Chen, Bin; Li, Zheng-Zheng; Zeng, Xin-Xing] Nanchang Univ, Affiliated Hosp 2, Jiangxi Med Coll, Nanchang 330006, Jiangxi, Peoples R China.
   [Chen, Bo-Fan; Liu, Li; Lin, Fang-Zhen; Zeng, Hai-Min; Huang, Hai-Qiang; Zhang, Chun-Fang; Liu, Cong-Cong; Peng, Jie; Wang, Yun-Fa; Wang, Zhi-Lin; Chen, Bin; Li, Zheng-Zheng; Zeng, Xin-Xing] Nanchang Univ, Clin Med Coll 2, Jiangxi Med Coll, 1299 Xuefu Ave, Nanchang 330006, Jiangxi, Peoples R China.
   [Chen, Xiang] Nanchang Univ, Affiliated Hosp 2, Jiangxi Med Coll, Dept Rehabil Med, Nanchang 330006, Jiangxi, Peoples R China.
   [Liu, De-Le] Nanchang Med Coll, Jiangxi Prov Peoples Hosp, Affiliated Hosp 1, Nanchang 330006, Jiangxi, Peoples R China.
   [Liu, Yun] Nanchang Univ, Jiangxi Mental Hosp, Dept Psychiat, Nanchang 330029, Jiangxi, Peoples R China.
C3 Nanchang University; Nanchang University; Nanchang University; Nanchang
   Medical College; Nanchang University
RP Zeng, XX (corresponding author), Nanchang Univ, Clin Med Coll 2, Jiangxi Med Coll, 1299 Xuefu Ave, Nanchang 330006, Jiangxi, Peoples R China.
EM 18679166679@163.com
RI Liu, Congcong/HLG-9805-2023; Zhang, Chunfang/S-9132-2016
FU National College Students' Innovative Entrepreneurial Training Plan
   Program [202410403067]; Innovation and Entrepreneurship Training Program
   for College Students in Jiangxi Province [S202410403035]
FX Supported by the National College Students' Innovative Entrepreneurial
   Training Plan Program, No. 202410403067; and the Innovation and
   Entrepreneurship Training Program for College Students in Jiangxi
   Province, No. S202410403035.
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NR 80
TC 0
Z9 0
U1 8
U2 8
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 7041 Koll Center Parkway, Suite 160, PLEASANTON, CA, UNITED STATES
SN 2220-3206
J9 WORLD J PSYCHIATR
JI World J. Psychiatr.
PD JAN 19
PY 2025
VL 15
IS 1
AR 100685
DI 10.5498/wjp.v15.i1.100685
PG 16
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychiatry
GA U7J5R
UT WOS:001413512100016
PM 39831017
DA 2025-06-11
ER

PT J
AU Rosa, D
   Villa, G
   Bonetti, L
   Togni, S
   Destrebecq, A
   Montanari, E
   Terzoni, S
AF Rosa, Debora
   Villa, Giulia
   Bonetti, Loris
   Togni, Serena
   Destrebecq, Anne
   Montanari, Emanuele
   Terzoni, Stefano
TI The relationship between overactive bladder, metabolic syndrome and
   shift work: A literature review
SO INTERNATIONAL JOURNAL OF UROLOGICAL NURSING
LA English
DT Review
DE metabolic syndrome; night shift; nurse; overactive bladder
ID NURSING PERSONNEL; ASSOCIATION; WOMEN; CRITERIA; STRESS; LINK
AB Could shift nurses develop overactive bladder (OAB) as a result of metabolic syndrome (MetS)? Shift work and consequent sleep disorders are risk factors of developing MetS. The aim of this literature review was to describe the correlation between MetS OAB and shift work. Search terms (free terms, MeSH): 'metabolic syndrome', 'urologic diseases'; papers published in the last 10 years (2009-2019) were searched in major medical databases (PubMed, CINAHL, Scopus, Embase and Cochrane Database of Systematic Review). We included all randomized controlled trials, observational studies, reviews and we included papers studying MetS and OAB. Quality assessment of the papers was conducted according to the Dixon-Woods checklist. Seven articles were analysed. The literature review pointed out that insulin resistance, hypertension, obesity, high-density lipoproteins (HDL), cholesterol and triglycerides have a relationship with MetS. The prevalence of obesity and insulin resistance increases the risk of urolithiasis especially in women. Nurses are an occupational category at risk for MetS, due mainly to shift work. All this could therefore put nurses in a position to develop OAB, but studies are needed that analyse the urinary habits of this professional category to prevent bad habits and reduce absenteeism.
C1 [Rosa, Debora] San Luca Hosp, IRCCS Ist Auxol Italiano, Dept Cardiovasc Neural & Metab Sci, Piazzale Brescia 20, I-20149 Milan, Italy.
   [Villa, Giulia] Univ Vita Salute San Raffaele, Ctr Nursing Res & Innovat, Milan, Italy.
   [Bonetti, Loris] Ente Osped Cantonale, Dept Nursing, Nursing Res Competence Ctr, Bellinzona, Switzerland.
   [Bonetti, Loris] Univ Appl Sci & Arts Southern Switzerland SUPS, Dept Business Econ Hlth & Social Care, Manno, Switzerland.
   [Togni, Serena] Fdn IRCCS Natl Canc Inst, Hlth Care Profess Dept, Milan, Italy.
   [Destrebecq, Anne; Montanari, Emanuele] Univ Milan, Dept Biomed Sci Hlth, Milan, Italy.
   [Montanari, Emanuele] Fdn IRCCS Ca Granda Osped Maggiore Policlin, Dept Urol, Milan, Italy.
   [Terzoni, Stefano] San Paolo Teaching Hosp, San Paolo Bachelor Sch Nursing, Milan, Italy.
C3 IRCCS Istituto Auxologico Italiano; Vita-Salute San Raffaele University;
   Fondazione IRCCS Istituto Nazionale Tumori Milan; University of Milan;
   IRCCS Ca Granda Ospedale Maggiore Policlinico
RP Rosa, D (corresponding author), San Luca Hosp, IRCCS Ist Auxol Italiano, Dept Cardiovasc Neural & Metab Sci, Piazzale Brescia 20, I-20149 Milan, Italy.
EM d.rosa@auxologico.it
RI Villa, Giulia/AAU-5964-2020; Rosa, Debora/AAG-8957-2021; Destrebecq,
   Anne/L-7920-2016; Terzoni, Stefano/AAH-7582-2021; Bonetti,
   Loris/T-6756-2019; Togni, Serena/JKH-6435-2023; MONTANARI,
   EMANUELE/I-8034-2015
OI Terzoni, Stefano/0000-0002-0716-5663; Villa, Giulia/0000-0001-7429-0504;
   Bonetti, Loris/0000-0003-0694-0880; Togni, Serena/0000-0002-8518-1036;
   Rosa, Debora/0000-0002-1440-3092; MONTANARI,
   EMANUELE/0000-0002-3586-666X
CR Akin Y, 2016, WIEN KLIN WOCHENSCHR, V128, pS581, DOI 10.1007/s00508-015-0725-7
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NR 24
TC 1
Z9 1
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1749-7701
EI 1749-771X
J9 INT J UROL NURS
JI Int. J. Urol. Nurs.
PD JUL
PY 2022
VL 16
IS 2
BP 73
EP 79
DI 10.1111/ijun.12303
EA DEC 2021
PG 7
WC Nursing; Urology & Nephrology
WE Emerging Sources Citation Index (ESCI)
SC Nursing; Urology & Nephrology
GA 1X5ZI
UT WOS:000728675100001
DA 2025-06-11
ER

PT J
AU Umbro, I
   Fabiani, V
   Fabiani, M
   Angelico, F
   Del Ben, M
AF Umbro, Ilaria
   Fabiani, Valerio
   Fabiani, Mario
   Angelico, Francesco
   Del Ben, Maria
TI Association between non-alcoholic fatty liver disease and obstructive
   sleep apnea
SO WORLD JOURNAL OF GASTROENTEROLOGY
LA English
DT Review
DE Continuous positive air pressure; Non-alcoholic fatty liver disease;
   Non-alcoholic steatohepatitis; Obstructive sleep apnea; Obstructive
   sleep disorders; Sleep apnea
ID POSITIVE AIRWAY PRESSURE; INSULIN-RESISTANCE; CARDIOMETABOLIC RISK;
   DAYTIME SLEEPINESS; METABOLIC SYNDROME; ATHEROSCLEROSIS;
   STEATOHEPATITIS; FIBROSIS; HYPOXIA; OBESITY
AB BACKGROUND
   Non-alcoholic fatty liver disease (NAFLD) is an emerging liver disease and currently the most common cause of incidental abnormal liver tests. The pathogenesis of NAFLD is multifactorial and many mechanisms that cause fatty liver infiltration, inflammation, oxidative stress and progressive fibrosis have been proposed. Obstructive sleep apnea (OSA) may be linked with the pathogenesis and the severity of NAFLD.
   AIM
   To study the association between NAFLD and OSA considering also the efficacy of continuous positive airway pressure (CPAP) treatment.
   METHODS
   A PubMed search was conducted using the terms "non-alcoholic fatty liver disease AND (obstructive sleep apnea OR obstructive sleep disorders OR sleep apnea)". Research was limited to title/abstract of articles published in English in the last 5 years; animal and child studies, case reports, commentaries, letters, editorials and meeting abstracts were not considered. Data were extracted on a standardized data collection table which included: First author, publication year, country, study design, number of patients involved, diagnosis and severity of OSA, diagnosis of NAFLD, patient characteristics, results of the study.
   RESULTS
   In total, 132 articles were initially retrieved on PubMed search and 77 in the last five years. After removal of irrelevant studies, 13 articles were included in the qualitative analysis. There was a total of 2753 participants across all the studies with a mean age between 42 and 58 years. The proportion of males ranged from 21% to 87.9% and the mean body mass index ranged from 24.0 to 49.9 kg/m(2). The results of this review showed an increased prevalence of NAFLD in patients with diagnosis of OSA, even in the absence of coexisting comorbidities such as obesity or metabolic syndrome. Furthermore, the severity of NAFLD is associated with the increase in OSA severity. Effective CPAP treatment, although not always decisive, may stabilize or slow NAFLD progression with benefits on metabolic and cardiovascular functions.
   CONCLUSION
   In NAFLD patients, although asymptomatic, it is recommended to systematically perform polysomnography in order to early and better treat them before the development of potentially life threatening systemic dysfunctions.
C1 [Umbro, Ilaria] Sapienza Univ Rome, Dept Anat Histol Forens Med & Orthoped Sci, Via Alfonso Borelli 50, I-00161 Rome, Italy.
   [Fabiani, Valerio] Sapienza Univ Rome, Dept Neurosci Mental Hlth & Sensory Organs, I-00123 Rome, Italy.
   [Fabiani, Mario] Sapienza Univ Rome, Dept Sense Organs, I-00161 Rome, Italy.
   [Angelico, Francesco] Sapienza Univ Rome, Dept Publ Hlth & Infect Dis, I-00161 Rome, Italy.
   [Del Ben, Maria] Sapienza Univ Rome, Dept Clin Internal Anesthet & Cardiovasc Sci, I-00161 Rome, Italy.
C3 Sapienza University Rome; Sapienza University Rome; Sapienza University
   Rome; Sapienza University Rome; Sapienza University Rome
RP Umbro, I (corresponding author), Sapienza Univ Rome, Dept Anat Histol Forens Med & Orthoped Sci, Via Alfonso Borelli 50, I-00161 Rome, Italy.
EM ilaria.umbro@uniroma1.it
RI Angelico, Francesco/AAB-6585-2020; Del Ben, Maria/AAE-7603-2020
OI , Mario/0000-0002-5290-5544
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NR 53
TC 39
Z9 41
U1 2
U2 16
PU BAISHIDENG PUBLISHING GROUP INC
PI PLEASANTON
PA 7041 Koll Center Parkway, Suite 160, PLEASANTON, CA, UNITED STATES
SN 1007-9327
EI 2219-2840
J9 WORLD J GASTROENTERO
JI World J. Gastroenterol.
PD MAY 28
PY 2020
VL 26
IS 20
DI 10.3748/wjg.v26.i20.2669
PG 14
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA LW6OS
UT WOS:000539264100016
PM 32523319
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Adouni, K
   Zouaoui, O
   Chandoura, H
   Thouri, A
   Ben Lamine, J
   Santos-Buelga, C
   González-Paramás, AM
   Maggi, F
   Mosbah, H
   Haouas, Z
   Neffati, F
   Achour, L
AF Adouni, Khaoula
   Zouaoui, Olfa
   Chandoura, Hassiba
   Thouri, Amira
   Ben Lamine, Jihen
   Santos-Buelga, Celestino
   Gonzalez-Paramas, Ana M.
   Maggi, Filippo
   Mosbah, Habib
   Haouas, Zohra
   Neffati, Fadoua
   Achour, Lotfi
TI  In vitro antioxidant activity, α-glucosidase inhibitory
   potential and in vivo protective effect of Asparagus
   stipularis Forssk aqueous extract against high-fructose diet-induced
   metabolic syndrome in rats
SO JOURNAL OF FUNCTIONAL FOODS
LA English
DT Article
DE Asparagus stipularis Forssk; alpha-Glucosidase inhibitory potential;
   High-fructose diet; Metabolic syndrome
ID IMPROVES ANTIOXIDANT STATUS; INDUCED INSULIN-RESISTANCE; HEPATIC
   OXIDATIVE STRESS; PANCREATIC BETA-CELLS; GREEN TEA; POSTPRANDIAL
   HYPERGLYCEMIA; HYPOGLYCEMIC ACTIVITY; QUERCETIN; PROTECTS; CONSUMPTION
AB The study was carried out to evaluate the in vitro antioxidant, alpha-glucosidase inhibitory potential and the protective effect of Asparagus stipularis Forssk aqueous extract against high-fructose diet (HFD; 10% fructose solution for 5 months) induced metabolic syndrome in rats. An A. stipularis shoots decoction (ASD) was administered orally (100 and 300 mg/kg body weight), daily for 4 weeks. Controls were performed using metformin (150 mg/kg) as a standard drug. HPLC-MS analysis showed hydroxycinnamoyl derivatives and flavonoid glycosides as the major constituents of ASD. Fructose fed rats showed hyperglycemia, dyslipidemia, impaired glucose tolerance and an increase of inflammation markers (alkaline phosphatase, aspartate transaminase and alanine transaminase) together with higher values of lipid peroxidation and lowered activities of antioxidants enzymes in liver. Hepatic histopathological examinations were performed. Variable sized fat vacuoles and diffuse lymphocytic infiltration were observed. ASD treatment prevented these abnormalities, demonstrating its protective effect against HFD-induced metabolic syndrome in rats.
C1 [Adouni, Khaoula; Zouaoui, Olfa; Chandoura, Hassiba; Thouri, Amira; Ben Lamine, Jihen; Mosbah, Habib; Achour, Lotfi] Univ Monastir, Lab Rech Bioressources Biol Integrat & Valorisat, Monastir, Tunisia.
   [Santos-Buelga, Celestino; Gonzalez-Paramas, Ana M.] Univ Salamanca, Fac Farm, GIP, USAL, Campus Miguel de Unamuno, E-37007 Salamanca, Spain.
   [Maggi, Filippo] Univ Camerino, Sch Pharm, Camerino, Italy.
   [Haouas, Zohra] Fac Med, Lab Histol & Cytogenet, Monastir, Tunisia.
   [Neffati, Fadoua] Hop Univ Monastir, Lab Biochim, Monastir, Tunisia.
C3 Universite de Monastir; University of Salamanca; University of Camerino;
   Universite de Monastir; Universite de Monastir; Hopital Fattouma
   Bourguiba
RP Adouni, K (corresponding author), Univ Monastir, Lab Rech Bioressources Biol Integrat & Valorisat, Monastir, Tunisia.
EM khawla.adouni01@gmail.com
RI chahdoura, hassiba/N-7612-2019; Maggi, Filippo/AAI-1551-2020;
   Gonzalez-Paramas, Ana Maria/D-2229-2011; Santos-Buelga,
   Celestino/A-1071-2008
OI Maggi, Filippo/0000-0003-1375-4744; Gonzalez-Paramas, Ana
   Maria/0000-0001-5477-0703; Santos-Buelga, Celestino/0000-0001-6592-5299
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NR 76
TC 8
Z9 10
U1 0
U2 25
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1756-4646
EI 2214-9414
J9 J FUNCT FOODS
JI J. Funct. Food.
PD AUG
PY 2018
VL 47
BP 521
EP 530
DI 10.1016/j.jff.2018.06.006
PG 10
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA GN4RH
UT WOS:000439019200055
DA 2025-06-11
ER

PT J
AU Frisbee, JC
   Goodwill, AG
   Frisbee, SJ
   Butcher, JT
   Wu, F
   Chantler, PD
AF Frisbee, Jefferson C.
   Goodwill, Adam G.
   Frisbee, Stephanie J.
   Butcher, Joshua T.
   Wu, Fan
   Chantler, Paul D.
TI Microvascular perfusion heterogeneity contributes to peripheral vascular
   disease in metabolic syndrome
SO JOURNAL OF PHYSIOLOGY-LONDON
LA English
DT Article; Proceedings Paper
CT Symposium on Impact of Physical Activity, Ageing, Obesity and Metabolic
   Syndrome on Muscle Microvascular Perfusion and Endothelial Metabolism at
   the Annual Meeting of the Physiological-Society
CY JUL 01, 2014
CL London, ENGLAND
SP Physiol Soc
ID IMPAIRS FUNCTIONAL VASODILATION; SKELETAL-MUSCLE PERFUSION;
   INSULIN-RESISTANCE; ZUCKER; BLOOD; RAREFACTION; DEFINITION; HEMATOCRIT;
   EXPRESSION; RESPONSES
AB A major challenge facing public health is the increased incidence and prevalence of the metabolic syndrome, a clinical condition characterized by excess adiposity, impaired glycaemic control, dyslipidaemia and moderate hypertension. The greatest concern for this syndrome is the profound increase in risk for development of peripheral vascular disease (PVD) in afflicted persons. However, ongoing studies suggest that reductions in bulk blood flow to skeletal muscle may not be the primary contributor to the premature muscle fatigue that is a hallmark of PVD. Compelling evidence has been provided suggesting that an increasingly spatially heterogeneous and temporally stable distribution of blood flow at successive arteriolar bifurcations in metabolic syndrome creates an environment where a large number of the pre-capillary arterioles have low perfusion, low haematocrit, and are increasingly confined to this state, with limited ability to adapt perfusion in response to a challenged environment. Single pharmacological interventions are unable to significantly restore function owing to a divergence in their spatial effectiveness, although combined therapeutic approaches to correct adrenergic dysfunction, elevated oxidant stress and increased thromboxane A(2) improve perfusion-based outcomes. Integrated, multi-target therapeutic interventions designed to restore healthy network function and flexibility may provide for superior outcomes in subjects with metabolic syndrome-associated PVD.
C1 [Frisbee, Jefferson C.; Goodwill, Adam G.; Butcher, Joshua T.] W Virginia Univ, Hlth Sci Ctr, Dept Physiol & Pharmacol, Morgantown, WV 26506 USA.
   [Frisbee, Jefferson C.; Goodwill, Adam G.; Frisbee, Stephanie J.; Butcher, Joshua T.; Chantler, Paul D.] W Virginia Univ, Hlth Sci Ctr, Ctr Cardiovasc & Resp Sci, Morgantown, WV 26506 USA.
   [Frisbee, Stephanie J.] W Virginia Univ, Hlth Sci Ctr, Dept Hlth Policy Management & Leadership, Morgantown, WV 26506 USA.
   [Wu, Fan] Novartis Inst BioMed Res Drug Metab & Pharmacok, E Hanover, NJ USA.
   [Chantler, Paul D.] W Virginia Univ, Hlth Sci Ctr, Div Exercise Physiol, Morgantown, WV 26506 USA.
C3 West Virginia University; West Virginia University; West Virginia
   University; West Virginia University
RP Frisbee, JC (corresponding author), W Virginia Univ, Ctr Cardiovasc & Resp Sci, Dept Physiol & Pharmacol, Robert C Byrd Hlth Sci Ctr,Sch Med, POB 9105, Morgantown, WV 26505 USA.
EM jefrisbee@hsc.wvu.edu
RI Butcher, Joshua/ABH-7212-2022; Goodwill, Adam/N-4889-2016
OI Butcher, Joshua/0000-0002-7341-1949; Goodwill, Adam/0000-0003-3701-3713;
   Frisbee, Jefferson/0000-0003-2751-0599; Wu, Fan/0000-0001-8339-4049;
   Frisbee, Stephanie/0000-0003-1526-1839
FU NIDDK NIH HHS [P30 DK097512] Funding Source: Medline
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NR 49
TC 23
Z9 26
U1 0
U2 11
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-3751
EI 1469-7793
J9 J PHYSIOL-LONDON
JI J. Physiol.-London
PD APR 15
PY 2016
VL 594
IS 8
BP 2233
EP 2243
DI 10.1113/jphysiol.2014.285247
PG 11
WC Neurosciences; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Neurosciences & Neurology; Physiology
GA DJ6VH
UT WOS:000374350800020
PM 25384789
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Dailey, G
AF Dailey, G.
TI Beyond insulin replacement: addressing the additional needs of the
   diabetes patient
SO DIABETES OBESITY & METABOLISM
LA English
DT Review
DE cannabinoid-1 receptor; cardiometabolic risk; dipeptidyl peptidase 4;
   glucagon-like peptide 1; type 2 diabetes mellitus
ID DIPEPTIDYL PEPTIDASE-4 INHIBITOR; CANNABINOID-1 RECEPTOR BLOCKER;
   PROTEIN-TYROSINE-PHOSPHATASE; CARDIOVASCULAR RISK-FACTORS;
   METFORMIN-TREATED PATIENTS; IMPROVES GLYCEMIC CONTROL; OVERWEIGHT
   PATIENTS; HEART-FAILURE; MYOCARDIAL-INFARCTION; EXENATIDE EXENDIN-4
AB The management of type 2 diabetes mellitus (T2DM) typically focuses on correcting dysglycaemia to reduce risk for microvascular and macrovascular complications, possibly by reducing glucose-mediated oxidative stress. However, other cardiometabolic risk factors, including abdominal obesity and dyslipidaemia are often overlooked in the quest for perfect glucose control. The currently used antidiabetic agents, including insulin, metformin, sulphonylureas and thiazolidinediones, have limited efficacy on these risk factors. A number of new therapeutic agents are undergoing clinical development, including glucagon-like peptide 1 mimetics (exenatide and liraglutide) and dipeptidyl peptidase 4 inhibitors (sitagliptin and vildagliptin), which target the incretin system, and the cannabinoid-1 receptor antagonists (rimonabant), which target the endocannabinoid system, may hold some promise for meeting these unmet needs. In this review, the clinical properties of these agents and potential treatment pathways to best use these agents are discussed for improving the management of T2DM and cardiovascular risk.
C1 [Dailey, G.] Scripps Clin Torrey Pines, Dept Endocrinol & Diabet, San Diego, CA USA.
C3 Scripps Research Institute
RP Dailey, G (corresponding author), Scripps Clin Torrey Pines, Dept Endocrinol & Diabet, 10666 N Torrey Pines Rd, La Jolla, CA 92037 USA.
EM dailey.george@scrippshealth.org
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NR 58
TC 9
Z9 10
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1462-8902
EI 1463-1326
J9 DIABETES OBES METAB
JI Diabetes Obes. Metab.
PD JUL
PY 2008
VL 10
SU 2
BP 83
EP 97
DI 10.1111/j.1463-1326.2008.00847.x
PG 15
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 312UY
UT WOS:000256697900010
PM 18577160
DA 2025-06-11
ER

PT J
AU McElroy, SL
AF McElroy, Susan L.
TI Obesity in Patients With Severe Mental Illness: Overview and Management
SO JOURNAL OF CLINICAL PSYCHIATRY
LA English
DT Article; Proceedings Paper
CT Teleconference on Balancing the Equation - Managing Comorbidities in
   Patients With Severe Mental Illness
CY AUG, 2008
CL ELECTR NETWORK
ID INDUCED WEIGHT-GAIN; 1ST-EPISODE SCHIZOPHRENIA-PATIENTS; NATIONAL
   EPIDEMIOLOGIC SURVEY; PLACEBO-CONTROLLED TRIAL; DRUG-NAIVE PATIENTS;
   BIPOLAR-I-DISORDER; BODY-MASS INDEX; DOUBLE-BLIND; METABOLIC SYNDROME;
   PHARMACOLOGICAL-TREATMENT
AB Severe mental illness and obesity are each serious public health problems that overlap to a clinically significant extent. Unfortunately, some of the most effective medications for severe mental illness are associated with the greatest weight gain, and the most effective strategy for severe obesity, bariatric surgery, is a treatment of last resort. First-line medication choices for patients with severe mental illness and obesity should be effective for treating the mental disorder, safe, well-tolerated, and, if possible, weight-neutral or associated with weight loss. If drugs with weight-inducing effects must be used, emerging data indicate that behavioral weight management, if not already in place, should be implemented and that adjunctive pharmacotherapeutic strategies should be considered. Severe mental illness with obesity must be viewed as 2 chronic illnesses that each require long-term management. (J Clin Psychiatry 2009;70[suppl 3]:12-21)
C1 Lindner Ctr HOPE, Mason, OH 45040 USA.
RP McElroy, SL (corresponding author), Lindner Ctr HOPE, 4075 Old Western Row Rd, Mason, OH 45040 USA.
EM susan.mcelroy@lindnercenter.org
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NR 111
TC 63
Z9 70
U1 0
U2 16
PU PHYSICIANS POSTGRADUATE PRESS
PI MEMPHIS
PA P O BOX 752870, MEMPHIS, TN 38175-2870 USA
SN 0160-6689
EI 1555-2101
J9 J CLIN PSYCHIAT
JI J. Clin. Psychiatry
PY 2009
VL 70
SU 3
BP 12
EP 21
DI 10.4088/JCP.7075su1c.03
PG 10
WC Psychology, Clinical; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI); Conference Proceedings Citation Index - Science (CPCI-S); Conference Proceedings Citation Index - Social Science &amp; Humanities (CPCI-SSH)
SC Psychology; Psychiatry
GA 465BQ
UT WOS:000267556000003
PM 19570497
OA Bronze
DA 2025-06-11
ER

PT J
AU Li, Y
   Tan, Q
   Guo, Y
   Wang, Q
   Ding, LJ
   Li, HX
   Zeng, H
AF Li, Yang
   Tan, Qiang
   Guo, Yao
   Wang, Qian
   Ding, Lijun
   Li, Hongxia
   Zeng, Hui
TI The Influence of Exercise Training on Endothelial Function, Serum Irisin
   and Inflammatory Markers in the Elderly with Metabolic Syndrome
SO CLINICAL LABORATORY
LA English
DT Article
DE metabolic syndrome; irisin; insulin resistance; inflammation;
   endothelial function
ID PROGENITOR CELLS; EXPRESSION; RESISTANCE; HEALTHY; STRESS; NUMBER; FNDC5
AB Background: Although exercise has beneficial effects on metabolic syndrome (Mets), the effects of exercise training on endothelial function and irisin level in the elderly with MetS remain controversial. The aim of this study is to evaluate the influence of exercise training on endothelial function and serum irisin level in the elderly with MetS.
   Methods: Volunteers with MetS were recruited (n = 30). After 8 consecutive weeks of exercise training, flow-mediated dilation (FMD), colony-forming units (CFU) of endothelial progenitor cell (EPC), and serum irisin level were determined. Body mass index (BMI), Homeostasis Model of Assessment of Insulin Resistance (HOMA-IR), and inflammatory markers were detected.
   Results: Exercise training program improved endothelial function, increased EPC-CFU, decreased HOMA-IR and inflammatory markers in patients with metabolic syndrome. However, exercise training had no influence on the serum irisin level. Multivariate linear regression analysis showed that change of EPC-CFU and HOMA-IR were independent prognostic risk factors for change of FMD.
   Conclusions: Exercise training improved endothelial function, alleviated insulin resistance and inflammation in the elderly with MetS. The findings suggest that exercise training program is an effective means for the treatment of MetS in the elderly.
C1 [Li, Yang; Tan, Qiang; Guo, Yao; Wang, Qian; Ding, Lijun; Li, Hongxia; Zeng, Hui] Hebei Med Univ, Hosp Qinhuangdao 1, Dept Cardiol, Qinhuangdao, Hebei, Peoples R China.
C3 Hebei Medical University
RP Tan, Q (corresponding author), Hebei Med Univ, Hosp Qinhuangdao 1, Qinhuangdao, Hebei, Peoples R China.
EM qhdtanqiang@aliyun.com
RI DING, LIJUN/LRC-4470-2024
FU HEBEI HEALTH SCIENTIFIC SUPPORTING PROJECTS [20171252]; Qinhuangdao
   city's scientific supporting projects [201805A031]
FX This article was supported by HEBEI HEALTH SCIENTIFIC SUPPORTING
   PROJECTS (20171252) and Qinhuangdao city's scientific supporting
   projects (201805A031).
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NR 28
TC 6
Z9 6
U1 0
U2 5
PU CLIN LAB PUBL
PI HEIDELBERG
PA IM BREITSPIEL 15, HEIDELBERG, D-69126, GERMANY
SN 1433-6510
J9 CLIN LAB
JI Clin. Lab.
PY 2021
VL 67
IS 3
BP 689
EP 696
DI 10.7754/Clin.Lab.2020.200446
PG 8
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA RZ6XJ
UT WOS:000648745300006
PM 33739044
DA 2025-06-11
ER

PT J
AU Nucera, S
   Scarano, F
   Macrì, R
   Mollace, R
   Gliozzi, M
   Carresi, C
   Ruga, S
   Serra, M
   Tavernese, A
   Caminiti, R
   Coppoletta, A
   Cardamone, A
   Montalcini, T
   Pujia, A
   Palma, E
   Muscoli, C
   Barillà, F
   Musolino, V
   Mollace, V
AF Nucera, Saverio
   Scarano, Federica
   Macri, Roberta
   Mollace, Rocco
   Gliozzi, Micaela
   Carresi, Cristina
   Ruga, Stefano
   Serra, Maria
   Tavernese, Annamaria
   Caminiti, Rosamaria
   Coppoletta, Annarita
   Cardamone, Antonio
   Montalcini, Tiziana
   Pujia, Arturo
   Palma, Ernesto
   Muscoli, Carolina
   Barilla, Francesco
   Musolino, Vincenzo
   Mollace, Vincenzo
TI The Effect of an Innovative Combination of Bergamot Polyphenolic
   Fraction and Cynara cardunculus L. Extract on Weight Gain
   Reduction and Fat Browning in Obese Mice
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE WAT; BAT; adipose tissue dysfunction; inflammation; oxidative stress;
   nutraceuticals; metabolic syndrome
ID ADIPOSE-TISSUE PLASTICITY; DIET-INDUCED OBESITY; OXIDATIVE STRESS;
   INSULIN-RESISTANCE; INFLAMMATION; EXPRESSION; CHOLESTEROL; ACTIVATION;
   IMPACT; ALPHA
AB Obesity is one of the world's most serious public health issues, with a high risk of developing a wide range of diseases. As a result, focusing on adipose tissue dysfunction may help to prevent the metabolic disturbances commonly associated with obesity. Nutraceutical supplementation may be a crucial strategy for improving WAT inflammation and obesity and accelerating the browning process. The aim of this study was to perform a preclinical "proof of concept" study on Bergacyn (R), an innovative formulation originating from a combination of bergamot polyphenolic fraction (BPF) and Cynara cardunculus (CyC), for the treatment of adipose tissue dysfunction. In particular, Bergacyn (R) supplementation in WD/SW-fed mice at doses of 50 mg/kg given orally for 12 weeks, was able to reduce body weight and total fat mass in the WD/SW mice, in association with an improvement in plasma biochemical parameters, including glycemia, total cholesterol, and LDL levels. In addition, a significant reduction in serum ALT levels was highlighted. The decreased WAT levels corresponded to an increased weight of BAT tissue, which was associated with a downregulation of PPAR gamma as compared to the vehicle group. Bergacyn (R) was able to restore PPAR gamma levels and prevent NF-kB overexpression in the WAT of mice fed a WD/SW diet, suggesting an improved oxidative metabolism and inflammatory status. These results were associated with a significant potentiation of the total antioxidant status in WD/SW mice. Finally, our data show, for the first time, that Bergacyn (R) supplementation may be a valuable approach to counteract adipose tissue dysfunction and obesity-associated effects on cardiometabolic risk.
C1 [Nucera, Saverio; Scarano, Federica; Macri, Roberta; Mollace, Rocco; Gliozzi, Micaela; Ruga, Stefano; Serra, Maria; Tavernese, Annamaria; Caminiti, Rosamaria; Coppoletta, Annarita; Cardamone, Antonio; Muscoli, Carolina; Mollace, Vincenzo] Magna Graecia Univ Catanzaro, Inst Res Food Safety & Hlth IRC FSH, Dept Hlth Sci, Pharmacol Lab, I-88100 Catanzaro, Italy.
   [Mollace, Rocco; Barilla, Francesco] Univ Roma Tor Vergata, Dept Syst Med, I-00133 Rome, Italy.
   [Carresi, Cristina; Palma, Ernesto] Magna Graecia Univ Catanzaro, Inst Res Food Safety & Hlth IRC FSH, Dept Hlth Sci, Vet Pharmacol Lab, I-88100 Catanzaro, Italy.
   [Montalcini, Tiziana] Magna Graecia Univ Catanzaro, Dept Clin & Expt Med, Clin Nutr Unit, I-88100 Catanzaro, Italy.
   [Pujia, Arturo] Magna Graecia Univ Catanzaro, Dept Med & Surg Sci, I-88100 Catanzaro, Italy.
   [Musolino, Vincenzo] Magna Graecia Univ Catanzaro, Inst Res Food Safety & Hlth IRC FSH, Dept Hlth Sci, Pharmaceut Biol Lab, I-88100 Catanzaro, Italy.
   [Mollace, Vincenzo] Renato Dulbecco Inst, I-88046 Lamezia Terme, Catanzaro, Italy.
C3 Magna Graecia University of Catanzaro; University of Rome Tor Vergata;
   Magna Graecia University of Catanzaro; Magna Graecia University of
   Catanzaro; Magna Graecia University of Catanzaro; Magna Graecia
   University of Catanzaro
RP Macrì, R; Mollace, V (corresponding author), Magna Graecia Univ Catanzaro, Inst Res Food Safety & Hlth IRC FSH, Dept Hlth Sci, Pharmacol Lab, I-88100 Catanzaro, Italy.; Mollace, V (corresponding author), Renato Dulbecco Inst, I-88046 Lamezia Terme, Catanzaro, Italy.
EM saverio.nucera@hotmail.it; federicascar87@gmail.com;
   robertamacri85@gmail.com; rocco.mollace@gmail.com;
   micaela.gliozzi@gmail.com; carresi@unicz.it; rugast1@gmail.com;
   maria.serra@studenti.unicz.it; an.tavernese@gmail.com;
   rosamariacaminiti4@gmail.com; annarita.coppoletta1@gmail.com;
   tony.c@outlook.it; tmontalcini@unicz.it; pujia@unicz.it; palma@unicz.it;
   muscoli@unicz.it; francesco.barilla@uniroma2.it; v.musolino@unicz.it;
   mollace@libero.it
RI Gliozzi, Micaela/D-4405-2015; serra, maria/LSJ-0107-2024; Montalcini,
   Tiziana/AGV-1479-2022; Musolino, Vincenzo/AAD-2678-2019; carresi,
   cristina/AAC-6354-2022; Mollace, Rocco/ABH-5643-2020; nucera,
   saverio/AAC-6570-2022; Coppoletta, Annarita/LSK-7367-2024; Ruga,
   Stefano/JUV-6384-2023; SCARANO, FEDERICA/HNC-2414-2023; Palma,
   ERNESTO/KRP-9299-2024; Cardamone, Antonio/HGA-5612-2022; Muscoli,
   Carolina/G-2773-2011; MACRI', Roberta/AAC-5967-2022; BARILLA',
   Francesco/Q-2665-2016
OI BARILLA', Francesco/0000-0003-0594-7212; Ruga,
   Stefano/0009-0008-0401-4027; serra, maria/0009-0005-7736-2207;
   Coppoletta, Anna Rita/0009-0000-5576-1139; carresi,
   cristina/0000-0002-3509-5930; MONTALCINI, Tiziana/0000-0001-7048-5830;
   MACRI', Roberta/0000-0002-2345-6751; mollace,
   vincenzo/0000-0002-0392-7173; Muscoli, Carolina/0000-0002-1047-4467;
   Musolino, Vincenzo/0000-0002-4763-2211; Cardamone,
   Antonio/0000-0002-9091-1806; PALMA, Ernesto/0000-0003-4199-207X
FU Italian Ministry of Research
FX No Statement Available
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NR 67
TC 6
Z9 6
U1 0
U2 6
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD JAN
PY 2024
VL 25
IS 1
AR 191
DI 10.3390/ijms25010191
PG 15
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA ET9W8
UT WOS:001141313000001
PM 38203362
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Crescenzo, R
   Mazzoli, A
   Cancelliere, R
   Bucci, A
   Naclerio, G
   Baccigalupi, L
   Cutting, SM
   Ricca, E
   Iossa, S
AF Crescenzo, R.
   Mazzoli, A.
   Cancelliere, R.
   Bucci, A.
   Naclerio, G.
   Baccigalupi, L.
   Cutting, S. M.
   Ricca, E.
   Iossa, S.
TI Beneficial effects of carotenoid-producing cells of Bacillus
   indicus HU16 in a rat model of diet-induced metabolic syndrome
SO BENEFICIAL MICROBES
LA English
DT Article
DE insulin resistance; metabolic inflammation; Bacillus indicus HU16
ID HIGH-FAT DIET; INSULIN-RESISTANCE; VEGETABLE INTAKE; GUT MICROBIOTA;
   CARDIOVASCULAR-DISEASE; SERUM CONCENTRATIONS; OXIDATIVE STRESS;
   VITAMIN-E; FRUIT; OBESITY
AB A well-established rat model of diet-induced metabolic syndrome was used to evaluate the effects of the oral administration of spores or cells of HU16, a carotenoid-producing strain of Bacillus indicus. Symptoms of metabolic syndrome were induced in 90-days old, male Sprague-Dawley rats maintained for eight weeks on a high-fat diet, as previously reported. Parallel groups of animals under the same diet regimen also received a daily dose of 1x10(10) cells or spores of B. indicus HU16. Cells of strain HU16 were able to reduce symptoms of metabolic syndrome, plasma markers of inflammation and oxidative markers in plasma and liver to levels similar to those observed in rats under a standard diet. HU16 cells did not affect obesity markers or the accumulation of triglycerides in the liver of treated animals. Denaturing gradient gel electrophoresis analysis showed that the oral administration of HU16 cells did not significantly affect the gut microbiota of high fat-fed rats, suggesting that the observed beneficial effects are not due to a reshaping of the gut microbiota but rather to metabolites produced by HU16 cells.
C1 [Crescenzo, R.; Mazzoli, A.; Cancelliere, R.; Baccigalupi, L.; Ricca, E.; Iossa, S.] Univ Naples Federico II, Dept Biol, Via Cintia, I-80126 Naples, Italy.
   [Bucci, A.; Naclerio, G.] Univ Molise, Dept Biosciences & Terr, I-86090 Contrada Fonte Lappone, Pesche, Italy.
   [Cutting, S. M.] Royal Holloway Univ London, Sch Biol Sci, Bourne Labs 4 26, Egham TW20 OEX, Surrey, England.
C3 University of Naples Federico II; University of Molise; University of
   London; Royal Holloway University London
RP Iossa, S (corresponding author), Univ Naples Federico II, Dept Biol, Via Cintia, I-80126 Naples, Italy.
EM susiossa@unina.it
RI Naclerio, Gino/A-5692-2008; Ricca, Ezio/AAG-2998-2020; Bucci,
   Antonio/AAV-3771-2020; IOSSA, Susanna/O-1625-2016
OI Bucci, Antonio/0000-0002-9596-3058; Ricca, Ezio/0000-0002-7355-0332;
   mazzoli, arianna/0000-0003-4096-443X; Baccigalupi,
   Loredana/0000-0003-3070-161X; IOSSA, Susanna/0000-0001-6103-718X
FU University of Napoli 'Federico II'; Progetto ASI (Agenzia Spaziale
   Italiana) [2015-008-R.0]
FX This work was supported by a grant from University of Napoli 'Federico
   II' and by Progetto ASI (Agenzia Spaziale Italiana) N. 2015-008-R.0.
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NR 43
TC 24
Z9 24
U1 0
U2 16
PU WAGENINGEN ACADEMIC PUBLISHERS
PI WAGENINGEN
PA PO BOX 220, WAGENINGEN, 6700 AE, NETHERLANDS
SN 1876-2883
EI 1876-2891
J9 BENEF MICROBES
JI Benef. Mirbobes
PY 2017
VL 8
IS 5
BP 823
EP 831
DI 10.3920/BM2017.0025
PG 9
WC Microbiology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Microbiology; Nutrition & Dietetics
GA FJ9SD
UT WOS:000413120200015
PM 28969443
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Erol, A
AF Erol, A.
TI Systemic DNA Damage Response and Metabolic Syndrome as a Premalignant
   State
SO CURRENT MOLECULAR MEDICINE
LA English
DT Review
DE Metabolic syndrome; senescence; insulin resistance; oxidative stress;
   p53; FOXO; PARP
ID FOXO TRANSCRIPTION FACTORS; ACTIVATED PROTEIN-KINASE; NF-KAPPA-B;
   CELLULAR SENESCENCE; INSULIN-RESISTANCE; TUMOR SUPPRESSION;
   ADIPOSE-TISSUE; FREE-RADICALS; PLASMINOGEN-ACTIVATOR; SIGNALING NETWORK
AB Damaged DNA can lead to aneuploidy and/or chromosomal instability, which is believed to be major contributor to tumor progression. DNA damage in response to genotoxic and oncogenic stresses activate the tumor suppressor pathways initiating DNA damage response (DDR). One of the cellular fates in response to DDR is permanent growth arrest in mitotically active cells, including stem cells, leading to senescence. On the other hand, DDR reasons in adaptive changes in postmitotic cells. These cellular alterations happen through complex interactions and function to disrupt the existing cellular homeostasis. Significant metabolic changes occurred by the influence of the major tumor suppressor protein p53 and other related factors such as FOXO, AMPK, PARP, NF-kappa B and PGC-1 are discussed in the article. After a strong correlation established between the systemic DNA damage response to inhibit ongoing malignant transformation and metabolic syndrome characteristics, logical extrapolations for type 2 diabetes, cardiovascular disease, and aging are carried out. Finally, therapeutic evaluations are performed in the light of the novel pathophysiological data implying that "metabolic syndrome" is a real disease.
C1 [Erol, A.] Erol Project Dev House Disorders Energy Metab, Silivri Istanbul, Turkey.
RP Erol, A (corresponding author), Muammer Aksoy Caddesi, Elmas Sokak 4, Silivri Istanbul, Turkey.
EM adnanerol@nku.edu.tr
RI Erol, Adnan/AAJ-9616-2020
OI Erol, Adnan/0000-0002-2741-9755
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NR 155
TC 52
Z9 53
U1 0
U2 9
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1566-5240
EI 1875-5666
J9 CURR MOL MED
JI Curr. Mol. Med.
PD APR
PY 2010
VL 10
IS 3
BP 321
EP 334
DI 10.2174/156652410791065282
PG 14
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 589CD
UT WOS:000277121300011
PM 20334625
DA 2025-06-11
ER

PT J
AU Wang, HJ
   Cheng, YM
   Shao, DC
   Chen, JY
   Sang, Y
   Gui, T
   Luo, SM
   Li, JR
   Chen, C
   Ye, YG
   Yang, Y
   Li, YK
   Zha, ZG
AF Wang, Huajun
   Cheng, Yanmei
   Shao, Decheng
   Chen, Junyuan
   Sang, Yuan
   Gui, Tao
   Luo, Simin
   Li, Jieruo
   Chen, Chao
   Ye, Yongguang
   Yang, Yong
   Li, Yikai
   Zha, Zhengang
TI Metabolic Syndrome Increases the Risk for Knee Osteoarthritis: A
   Meta-Analysis
SO EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Review
ID NATIONAL-HEALTH; ASSOCIATION; HIP; ACCUMULATION; PREVALENCE; EXPRESSION;
   ADIPOKINES; CARTILAGE; DISEASE; STRESS
AB Background. Studies revealed that metabolic factors might contribute substantially to osteoarthritis ( OA) pathogenesis. There has been an increasing interest to understand the relationship between knee OA and the metabolic syndrome ( MetS). The purpose of this study was to explore the association between metabolic syndrome and knee osteoarthritis using meta-analysis. Methods. Databases, including PUBMED, EMBASE, and the Cochrane Library, were searched to get relevant studies. Data were extracted separately by two authors and pooled odds ratio ( OR) with 95% confidence interval ( CI) was calculated. Results. The meta-analysis was finished with 8 studies with a total of 3202 cases and 20968 controls finally retrieved from the database search. The crude pooled OR is 2.24 ( 95% CI = 1.38-3.64). Although there was significant heterogeneity among these studies, which was largely accounted for by a single study, the increase in risk was still significant after exclusion of that study. The pooled adjusted OR remained significant with pooled adjusted OR 1.05 ( 95% CI = 1.03-1.07, p < 0.00001). No publication bias was found in the present meta-analysis. Conclusions. The synthesis of available evidence supports that metabolic syndrome increases the risk for knee osteoarthritis, even after adjustment for many risk factors.
C1 [Wang, Huajun; Chen, Junyuan; Sang, Yuan; Gui, Tao; Luo, Simin; Li, Jieruo; Zha, Zhengang] Jinan Univ, Clin Coll 1, Guangzhou 510630, Guangdong, Peoples R China.
   [Wang, Huajun; Chen, Junyuan; Sang, Yuan; Gui, Tao; Luo, Simin; Li, Jieruo; Zha, Zhengang] Jinan Univ, Affiliated Hosp 1, Dept Orthoped, Guangzhou 510630, Guangdong, Peoples R China.
   [Cheng, Yanmei] Sun Yat Sen Univ, Affiliated Hosp 1, Guangzhou 510080, Guangdong, Peoples R China.
   [Shao, Decheng] Hebei Med Univ, Dept Orthoped, Hosp 3, Shijiazhuang 050051, Peoples R China.
   [Chen, Chao; Li, Yikai] Southern Med Univ, Sch Tradit Chinese Med, Dept Orthoped, Guangzhou 510515, Guangdong, Peoples R China.
   [Ye, Yongguang] Guangzhou Orthoped Hosp, Dept Orthoped, Guangzhou 510045, Guangdong, Peoples R China.
   [Yang, Yong] Xingtai Peoples Hosp, Dept Orthoped, Xingtai 054031, Hebei, Peoples R China.
C3 Jinan University; Jinan University; Sun Yat Sen University; Hebei
   Medical University; Southern Medical University - China
RP Zha, ZG (corresponding author), Jinan Univ, Clin Coll 1, Guangzhou 510630, Guangdong, Peoples R China.; Zha, ZG (corresponding author), Jinan Univ, Affiliated Hosp 1, Dept Orthoped, Guangzhou 510630, Guangdong, Peoples R China.
EM zhazhengang2@163.com
FU China Postdoctoral Science Foundation [2015M582480]; Natural Science
   Foundation of Guangdong Province [2016A030313100]; National Natural
   Science Foundation of China [81601219]
FX This study is funded by the grants from China Postdoctoral Science
   Foundation (2015M582480), Natural Science Foundation of Guangdong
   Province (2016A030313100), and National Natural Science Foundation of
   China (81601219).
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NR 35
TC 29
Z9 29
U1 1
U2 13
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1741-427X
EI 1741-4288
J9 EVID-BASED COMPL ALT
JI Evid.-based Complement Altern. Med.
PY 2016
VL 2016
AR 7242478
DI 10.1155/2016/7242478
PG 7
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA EA0JV
UT WOS:000386273700001
OA Green Published, hybrid, Green Submitted
DA 2025-06-11
ER

PT J
AU Vashishth, K
   Singh, SK
   Jain, A
   Bhatia, A
   Sharma, YP
AF Vashishth, Kanupriya
   Singh, Sumit K.
   Jain, Annish
   Bhatia, Alka
   Sharma, Yash P.
TI Pathological involvement of apoptotic and inflammatory molecules in
   cardiovascular remodeling in rats on high fructose diet-induced
   metabolic syndrome
SO JOURNAL OF FOOD BIOCHEMISTRY
LA English
DT Article
DE cardiovascular disease; caspase; CVD remodeling; fructose; metabolic
   syndrome; MMPs; NF kappa B; TNF-alpha
ID TNF-ALPHA; INSULIN-RESISTANCE; KAPPA-B; EXPRESSION; OBESITY; IMPROVES;
   ASSAY
AB Fructose consumption has been linked to manifestation of metabolic syndrome (MS); an emerging epidemic. The current study attempts to demonstrate fructose overconsumption-mediated cardiovascular disease (CVD) remodeling in Wistar rats. Rats were randomly segregated into control (CON) and high fructose diet (FFR) groups and received customized diets for 20 weeks. Levels of diabetic, lipid, antioxidant, markers, mRNA levels of inflammatory, apoptotic markers, and histopathological changes were assessed in excised hearts of both groups. Significant increase in uric acid, pro-oxidants diabetic, lipid, inflammatory markers, cytosolic cytochrome C, nuclear NF-kB-p65, and decrease in antioxidants was observed in FFR group. Abnormal myocardial architecture was observed in the FFR group along with elevated mRNA levels of inflammatory, apoptotic markers, and MMP-9, -2. The outcomes of the study are suggestive of role of aforementioned molecules in high fructose intake-mediated pathological deterioration of heart and development of MS-associated CVD progression.
   Practical applications
   Excessive fructose consumption in the form of high fructose corn syrup, sugary drinks, and commonly available fast foods has been shown to be linked with many diseases such as liver malfunction, metabolic syndrome diabetes, and cardiovascular diseases. However, delineated pathways and clear mechanisms and their role in cardiovascular remodeling due to excessive fructose consumption are yet to be established. The present study establishes the deleterious effects of foods with high sugar content on progression toward metabolic syndrome and cardiovascular remodeling. It further investigates the role of different pathways involved in the development of high fructose-induced diet-induced metabolic syndrome, and thereby leading to harmful effects on the hearts of rats consuming high fructose diet leading to cardiovascular in Wistar rats. The study suggests the role of immunomodulation and oxidative stress in the remodeling of cardiac muscles and in turn progression toward metabolic syndrome and cardiovascular remodeling. The study, therefore, throws light on the deleterious effects of consumption of foods and easily available fast foods on progression toward numerous non-communicable diseases.
C1 [Vashishth, Kanupriya; Jain, Annish; Sharma, Yash P.] Post Grad Inst Med Educ & Res, Dept Cardiol, Chandigarh 160012, India.
   [Singh, Sumit K.] Panjab Univ, Univ Inst Engn & Technol, Chandigarh, India.
   [Bhatia, Alka] Post Grad Inst Med Educ & Res, Dept Expt Med & Biotechnol, Chandigarh, India.
C3 Post Graduate Institute of Medical Education & Research (PGIMER),
   Chandigarh; Panjab University; Post Graduate Institute of Medical
   Education & Research (PGIMER), Chandigarh
RP Sharma, YP (corresponding author), Post Grad Inst Med Educ & Res, Dept Cardiol, Chandigarh 160012, India.
EM yashcardio@gmail.com
OI Singh, Sumit Kumar/0000-0001-9058-5468
CR Avramoglu RK, 2006, CLIN CHIM ACTA, V368, P1, DOI 10.1016/j.cca.2005.12.026
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NR 34
TC 2
Z9 2
U1 1
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0145-8884
EI 1745-4514
J9 J FOOD BIOCHEM
JI J. Food Biochem.
PD JUL
PY 2022
VL 46
IS 7
AR e14107
DI 10.1111/jfbc.14107
EA FEB 2022
PG 12
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA 2S1BL
UT WOS:000762348900001
PM 35156213
OA gold
DA 2025-06-11
ER

PT J
AU Toh, DWK
   Koh, ES
   Kim, JE
AF Toh, Darel Wee Kiat
   Koh, Evangelyn Sihui
   Kim, Jung Eun
TI Incorporating healthy dietary changes in addition to an increase in
   fruit and vegetable intake further improves the status of cardiovascular
   disease risk factors: A systematic review, meta-regression, and
   meta-analysis of randomized controlled trials
SO NUTRITION REVIEWS
LA English
DT Review
DE blood pressure; cholesterol; fruit; healthy diet; inflammation;
   lipoproteins; oxidative stress; triglycerides; vegetable
ID DENSITY-LIPOPROTEIN CHOLESTEROL; CORONARY-HEART-DISEASE; BLOOD-PRESSURE
   CHANGE; WEIGHT-LOSS; OXIDATIVE STRESS; CARDIOMETABOLIC RISK;
   LIPID-PEROXIDATION; METABOLIC SYNDROME; SERUM-CHOLESTEROL; NUT
   CONSUMPTION
AB Context: Fruit and vegetable (FV) intake has been associated with a reduced risk of cardiovascular disease (CVD). Beyond increasing FV intake, the incorporation of other healthy dietary changes may help to further attenuate CVD risk. Objective: A systematic review and meta-analysis was conducted to determine the effect of increasing FV intake to >3 servings daily as well as incorporating other healthy dietary changes on classical CVD risk factors through a systematic review, meta-regression, and meta-analysis of randomized controlled trials. Data Sources: The following databases were searched: PubMed, CINAHL Plus with Full Text, Medline (ProQuest), and Cochrane Library. Data Extraction: 82, 24, and 10 articles were selected for the systematic review, meta-regression, and meta-analysis, respectively. Data Analysis: Meta-regression analysis showed a dose-dependent response between the number of FV servings consumed in each intervention group and the blood triglyceride change value. Pooled weighted mean differences from the meta-analysis suggested that increasing FV intake to >3 servings daily contributes to significant decreases in triglyceride (-0.10 mmol/L; 95%CI, -0.18 to -0.01) and diastolic blood pressure (-1.99 mmHg; 95%CI, -2.28 to -1.70) as well as marginal decreases in total cholesterol and low-density lipoprotein cholesterol. While improvements were observed in the triglyceride and high-density lipoprotein cholesterol response following the incorporation of other healthy dietary changes, no additional cardiovascular benefits were observed when FV intake was increased from >3 to >5 servings daily. Conclusion: Increasing FV intake to >3 servings daily improves CVD risk factors, most distinctly triglyceride, especially when complemented with other healthy dietary changes.
C1 [Toh, Darel Wee Kiat; Koh, Evangelyn Sihui; Kim, Jung Eun] Natl Univ Singapore, Dept Chem, Food Sci & Technol Programme, Sci Dr 3, Singapore, Singapore.
C3 National University of Singapore
RP Kim, JE (corresponding author), Natl Univ Singapore, Dept Chem, Food Sci & Technol Programme, Sci Dr 3, Singapore, Singapore.
EM chmkje@nus.edu.sg
RI Kim, Jung Eun/LWI-5710-2024; Kim, Jung Eun/O-9332-2017
OI Kim, Jung Eun/0000-0002-3912-9042; Toh, Darel Wee
   Kiat/0000-0003-1608-0669
FU President's Graduate Fellowship from the National University of
   Singapore
FX There was no direct funding for this study. D.W.K.T. received the
   President's Graduate Fellowship from the National University of
   Singapore. The sponsor had no involvement in the design of the study; in
   the collection, analyses, or interpretation of data; in the writing of
   the manuscript; or in the decision to publish the results.
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NR 76
TC 24
Z9 24
U1 1
U2 17
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0029-6643
EI 1753-4887
J9 NUTR REV
JI Nutr. Rev.
PD JUL
PY 2020
VL 78
IS 7
BP 532
EP 545
DI 10.1093/nutrit/nuz104
PG 14
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA MG8BO
UT WOS:000546255200002
PM 31889199
DA 2025-06-11
ER

PT J
AU Yen, HY
   Lin, YH
   Wang, YF
   Fuh, JL
   Wang, SJ
   Chen, HS
   Chiang, SC
   Li, SR
   Lin, MH
   Chen, TJ
   Hwang, SJ
   Chang, HT
AF Yen, Hsin-Yeong
   Lin, Yi-Hsuan
   Wang, Yen-Feng
   Fuh, Jong-Ling
   Wang, Shuu-Jiun
   Chen, Harn-Shen
   Chiang, Shu-Chiung
   Li, Sih-Rong
   Lin, Ming-Hwai
   Chen, Tzeng-Ji
   Hwang, Shinn-Jang
   Chang, Hsiao-Ting
TI The association between metabolic syndrome components and cognitive
   function in community-dwelling middle-aged and older adults: the first
   wave result of a cohort study
SO JOURNAL OF HEALTH POPULATION AND NUTRITION
LA English
DT Article
DE Cognition; Older adults; Metabolic syndrome; Middle-aged; Montreal
   cognitive assessment taiwanese version
ID INSTRUMENTAL ACTIVITIES; RISK-FACTORS; IMPAIRMENT; DEMENTIA; DECLINE;
   TISSUE; FALLS; MOCA; FAT
AB BackgroundThe components of metabolic syndrome (MetS) have previously been demonstrated to be contributors to cognitive decline in older adults as individual factors, but not collectively as a syndrome. This study investigated whether adults >= 50 years old who meet the criteria for MetS were more likely to develop impaired cognition than those without MetS.MethodsAdults aged 50 years or older without significant cognitive impairment who received outpatient care at Taipei Veterans General Hospital were recruited. Waist circumference, blood tests for Mets components, and high-sensitivity C-reactive protein (hsCRP) were measured. Demographics, health condition, cognitive function (by Montreal Cognitive Assessment Taiwanese version, MoCA-T, and AD-8), depression symptoms (by Geriatric Depression Scale-15) and functional status (by Barthel's Index, and Lawton & Brody instrumental activities of daily living, IADL) were evaluated. Associations between MetS and cognitive function were analyzed by multivariate logistic regression.ResultsData of 567 participants were analyzed. The prevalence of MetS of the study population was 34.2%. MetS status was not significantly correlated to cognitive decline as indicated by Montreal Cognitive Assessment Taiwan version (p = 0.13) and AD-8 (p = 0.42). Mild abdominal obesity decreased the risk of developing impaired cognition in women (adjusted OR = 0.62, 95% CI = 0.42, 0.93, p = 0.02) but not in men (adjusted OR = 0.84, 95% CI = 0.46, 1.53, p = 0.58).ConclusionsMetS is not a significant contributory factor to cognitive decline in community-dwelling middle-aged and older adults. An optimal waist circumference in community-dwelling older women is protective against the development of mild dementia.
C1 [Yen, Hsin-Yeong; Lin, Yi-Hsuan; Wang, Yen-Feng; Fuh, Jong-Ling; Wang, Shuu-Jiun; Chen, Harn-Shen; Chiang, Shu-Chiung; Lin, Ming-Hwai; Chen, Tzeng-Ji; Hwang, Shinn-Jang; Chang, Hsiao-Ting] Natl Yang Ming Chiao Tung Univ, Coll Med, Sch Med, Taipei, Taiwan.
   [Lin, Yi-Hsuan] Taipei Vet Gen Hosp, Dept Med Educ, Taipei, Taiwan.
   [Wang, Yen-Feng; Fuh, Jong-Ling; Wang, Shuu-Jiun] Taipei Vet Gen Hosp, Neurol Inst, Dept Neurol, Taipei, Taiwan.
   [Chen, Harn-Shen] Taipei Vet Gen Hosp, Dept Internal Med, Taipei, Taiwan.
   [Li, Sih-Rong; Lin, Ming-Hwai; Chen, Tzeng-Ji; Hwang, Shinn-Jang; Chang, Hsiao-Ting] Taipei Vet Gen Hosp, Dept Family Med, Taipei, Taiwan.
   [Chen, Tzeng-Ji] Taipei Vet Gen Hosp, Hsinchu Branch, Dept Family Med, Hsinchu Cty, Taiwan.
   [Chen, Tzeng-Ji] Natl Chung Hsing Univ, Dept Postbaccalaureate Med, Taichung, Taiwan.
   [Hwang, Shinn-Jang] En Chu Kong Hosp, Dept Family Med, New Taipei, Taiwan.
C3 National Yang Ming Chiao Tung University; Taipei Veterans General
   Hospital; Taipei Veterans General Hospital; Taipei Veterans General
   Hospital; Taipei Veterans General Hospital; Taipei Veterans General
   Hospital; National Chung Hsing University
RP Chang, HT (corresponding author), Natl Yang Ming Chiao Tung Univ, Coll Med, Sch Med, Taipei, Taiwan.; Chang, HT (corresponding author), Taipei Vet Gen Hosp, Dept Family Med, Taipei, Taiwan.
EM htchang2@vghtpe.gov.tw
RI Chiang, Shu-Chiung/GPX-6643-2022; Fuh, Jong-Ling/AFQ-4531-2022; Chen,
   TJ/AAH-8430-2021
FU Taipei Veterans General Hospital; Taipei Veterans General Hospital
FX The authors would like to thank the participants for their time and
   contribution to the study, and the Taipei Veterans General Hospital for
   the use of its facilities. No external organizations had roles in the
   study design, data collection and analysis, or manuscript preparation.
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NR 52
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PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
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J9 J HEALTH POPUL NUTR
JI J. Heatlh Popul. Nutr.
PD MAR 29
PY 2025
VL 44
IS 1
AR 94
DI 10.1186/s41043-025-00824-3
PG 10
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA 0ST1Z
UT WOS:001455136400002
PM 40158120
OA gold
DA 2025-06-11
ER

PT J
AU Biava, PM
   Norbiato, G
AF Biava, Pier M.
   Norbiato, Guido
TI Getting an Insight into the Complexity of Major Chronic Inflammatory and
   Degenerative Diseases: A Potential New Systemic Approach to Their
   Treatment
SO CURRENT PHARMACEUTICAL BIOTECHNOLOGY
LA English
DT Article
DE Chronic inflammation; cytokines; glucocorticoids; glucocorticoid
   receptor; nuclear steroid receptor; neuroendocrine-lmmune-metabolic
   systems; epigenetic markers; cancer; brain; cardiovascular; obesity; HIV
   infection diseases; mesenchymal stem cells; stem cells differentiation
   stage factors
ID TUMOR-NECROSIS-FACTOR; DIFFERENTIATION STAGE FACTORS; MESENCHYMAL
   STEM-CELLS; ADVANCED HEPATOCELLULAR-CARCINOMA; ADIPOSE-TISSUE;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; PROSTATE-CANCER; INNATE
   IMMUNITY; TNF-ALPHA
AB As the modern society is troubled by multi-factorial diseases, research has been conducted on complex realities including chronic inflammation, cancer, obesity, HIV infection, metabolic syndrome and its detrimental cardiovascular complications as well as depression and other brain disorders. Deterioration of crucial homeostatic mechanisms in such diseases invariably results in activation of inflammatory mediators, chronic inflammation, loss in immunological function, increased susceptibility to diseases, alteration of metabolism, decrease of energy production and neuro-cognitive decline. Regulation of genes expression by epigenetic code is the dominant mechanism for the transduction of environmental inputs, such as stress and inflammation to lasting physiological changes. Acute and chronic stress determines DNA methylation and histone modifications in brain regions which may contribute to neuro-degenerative disorders. Nuclear glucocorticoids receptor interacts with the epigenoma resulting in a cortisol resistance status associated with a deterioration of the metabolic and immune functions. Gonadal steroids receptors have a similar capacity to produce epigenomic reorganization of chromatine structure. Epigenomic-induced reduction in immune cells telomeres length has been observed in many degenerative diseases, including all types of cancer. The final result of these epigenetic alterations is a serious damage to the neuro-endocrine-immune-metabolic adaptive systems. In this study, we propose a treatment with stem cells differentiation stage factors taken from zebrafish embryos which are able to regulate the genes expression of normal and pathological stem cells in a different specific way.
C1 [Biava, Pier M.] Sci Inst Res & Care Multimed, Milan, Italy.
   [Norbiato, Guido] L Sacco Univ Hosp, Endocrine & Metab Unit, Dept Specialist Dis, Milan, Italy.
C3 University of Milan; Luigi Sacco Hospital
RP Norbiato, G (corresponding author), L Sacco Univ Hosp, Endocrine & Metab Unit, Dept Specialist Dis, Milan, Italy.
EM guidonorbiato@libero.it
OI Biava, Pier Mario/0000-0003-3662-4643
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PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1389-2010
EI 1873-4316
J9 CURR PHARM BIOTECHNO
JI Curr. Pharm. Biotechnol.
PY 2015
VL 16
IS 9
BP 793
EP 803
DI 10.2174/138920101609150715141308
PG 11
WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
GA CM9GI
UT WOS:000358015000006
PM 26201608
DA 2025-06-11
ER

PT J
AU Tabvuma, TS
   Stanton, R
   Browne, G
   Happell, B
AF Tabvuma, Tracy Samkele
   Stanton, Robert
   Browne, Graeme
   Happell, Brenda
TI Mental health consumers' perspectives of physical health interventions:
   An integrative review
SO INTERNATIONAL JOURNAL OF MENTAL HEALTH NURSING
LA English
DT Review
DE consumer; experience; physical healthcare; psychiatric
ID SERVICE USERS EXPERIENCES; LIFE-STYLE; PSYCHOTIC DISORDERS; METABOLIC
   SYNDROME; NATIONAL-SURVEY; ILLNESS; PEOPLE; CARE; SCHIZOPHRENIA;
   INDIVIDUALS
AB Consumers of mental health services experience poor physical health compared to the general population, leading to long-term physical illness and premature death. Current research and policy activity prioritizes the physical health of consumers yet few of these recommendations have translated to practice. This implementation gap may be influenced by the paucity of literature exploring consumer perceptions and experiences with physical healthcare and treatment. As a result, little is understood about the views and attitudes of consumers towards interventions designed to improve their physical health. This integrative review aims to explore the literature regarding consumer perspectives of physical healthcare and, interventions to improve their physical health. A systematic search was undertaken using (i) CINAHL, (ii) MEDLINE, (iii) PsycINFO, (iv) Scopus, and (v) Google Scholar between September and December 2021. Sixty-one papers comprising 3828 consumer participants met the inclusion criteria. This review found that consumers provide invaluable insights into the barriers and enablers of physical healthcare and interventions. When consumers are authentically involved in physical healthcare evaluation, constructive and relevant recommendations to improve physical healthcare services, policy, and future research directions are produced. Consumer evaluation is the cornerstone required to successfully implement tailored physical health services.
C1 [Tabvuma, Tracy Samkele; Browne, Graeme; Happell, Brenda] Univ Newcastle, Sch Nursing & Midwifery, Coll Hlth Med & Wellbeing, 21 Long Bush Rise,Cobbitty 257, Callaghan, NSW, Australia.
   [Stanton, Robert] Cent Queensland Univ, Sch Hlth Med & Appl Sci, Rockhampton, Qld, Australia.
C3 University of Newcastle; Central Queensland University
RP Tabvuma, TS (corresponding author), Univ Newcastle, Sch Nursing & Midwifery, Coll Hlth Med & Wellbeing, 21 Long Bush Rise,Cobbitty 257, Callaghan, NSW, Australia.
EM tracy.tabvuma@uon.edu.au
RI Stanton, Rob/AAJ-5157-2020; Happell, Brenda/HSI-0570-2023
OI Happell, Brenda/0000-0002-7293-6583; Tabvuma, Tracy/0000-0001-6135-103X
FU University of Newcastle
FX Thank you to the University of Newcastle for supporting TT's Doctoral
   Thesis.
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NR 106
TC 14
Z9 14
U1 1
U2 11
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1445-8330
EI 1447-0349
J9 INT J MENT HEALTH NU
JI Int. J. Ment. Health Nurs.
PD OCT
PY 2022
VL 31
IS 5
BP 1046
EP 1089
DI 10.1111/inm.13000
EA APR 2022
PG 44
WC Nursing; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Psychiatry
GA 4N0MT
UT WOS:000778874000001
PM 35388954
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Dominguez, J
   Wu, PF
   Packer, CS
   Temm, C
   Kelly, KJ
AF Dominguez, Jesus
   Wu, Pengfei
   Packer, C. Subah
   Temm, Constance
   Kelly, Katherine J.
TI Lipotoxic and inflammatory phenotypes in rats with uncontrolled
   metabolic syndrome and nephropathy
SO AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
LA English
DT Article
DE diabetic nephropathies; lipid peroxidation
ID ACTIVATED PROTEIN-KINASE; ACETYL-COA CARBOXYLASE; CHRONIC
   KIDNEY-DISEASE; INSULIN-RESISTANCE; GLUCOSE-TRANSPORT; OXIDATIVE STRESS;
   ADIPONECTIN; MUSCLE; INJURY; ACCUMULATION
AB Anomalous inflammatory responses triggered by the metabolic syndrome cause renal injury. This discovery links renal lipid accumulation with lipotoxicity to inflammation and may explain the insidious fibrosis and cellular decay characteristic of nephropathy in the metabolic syndrome. However, it is not clear whether control of inflammation protects the kidney independently of lipid accumulation, which is a required step for lipotoxicity in hyperglycemia and dyslipidemia. We hypothesized that in rats with the metabolic syndrome, and overt nephropathy, treatment with mycophenolate mofetil (MMF; 10 mg center dot kg(-1)center dot day(-1) ip for 14 wk) would reduce the abnormal renal lipid depots and limit renal inflammation and injury. We studied groups of lean and obese F-1 hybrid Zucker fatty diabetic/spontaneous hypertensive heart failure (ZS) rats. MMF did not affect lean rats. In obese ZS rats, MMF did not change severe hyperglycemia or the higher kidney loads of unutilized lipid and peroxidation products. Nonetheless, MMF dramatically reduced diabetes/obesity-derived systemic and renal inflammation, limited renal size, hyperfiltration, and fibrosis. These data indicate that in rats, anti-inflammatory therapy presumably acting downstream, and independently of lipotoxicity, can effectively limit renal injury and fibrosis.
C1 Indiana Univ, Sch Med, Dept Med, Indianapolis, IN 46204 USA.
   Indiana Univ, Sch Med, Dept Physiol, Indianapolis, IN 46204 USA.
C3 Indiana University System; Indiana University Indianapolis; Indiana
   University System; Indiana University Indianapolis
RP Dominguez, J (corresponding author), VAMC, N 111,1481 W 10th St, Indianapolis, IN 46202 USA.
EM jhdoming@iupui.edu
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NR 55
TC 42
Z9 44
U1 0
U2 4
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 1931-857X
EI 1522-1466
J9 AM J PHYSIOL-RENAL
JI Am. J. Physiol.-Renal Physiol.
PD SEP
PY 2007
VL 293
IS 3
BP F670
EP F679
DI 10.1152/ajprenal.00021.2007
PG 10
WC Physiology; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology; Urology & Nephrology
GA 206AI
UT WOS:000249155900005
PM 17596532
DA 2025-06-11
ER

PT J
AU Le Grande, MR
   Beauchamp, A
   Driscoll, A
   Kerr, D
   Jackson, AC
AF Le Grande, Michael R.
   Beauchamp, Alison
   Driscoll, Andrea
   Kerr, Debra
   Jackson, Alun C.
TI Is Self-Reported Obstructive Sleep Apnea Associated with Cardiac
   Distress? A Network Analysis
SO HEART AND MIND
LA English
DT Article
DE Anxiety; cardiac distress; cardiac patients; depression; metabolic
   syndrome; network analysis; obesity; obstructive sleep apnea
ID CORONARY-HEART-DISEASE; CARDIOVASCULAR-DISEASE; RISK-FACTORS;
   DEPRESSION; STATEMENT; SYMPTOMS; PARTNERS; ANXIETY; OBESITY; HEALTH
AB Introduction: The relationship between obstructive sleep apnea (OSA), obesity, various metabolic variables, and psychosocial outcomes is complex. No studies have examined the association between these predictors and disease-specific distress related to heart disease (cardiac distress). We aimed to study the association between OSA and cardiac distress using a network analysis framework. Methods: This secondary analysis of an observational cross-sectional study conducted in 2021 consisted of 405 hospital- and community-sourced adults from Australia and the United States who reported an acute coronary event (such as a myocardial infarction, or procedures such as coronary artery bypass graft surgery, or percutaneous coronary intervention) in the previous 12 months. Participants were surveyed in relation to sociodemographic variables, clinical risk factors, comorbidities (including time since event, OSA, obesity, diabetes, hypertension, and hyperlipidemia), and cardiac distress (reported by the Cardiac Distress Inventory Short-Form). These data were subjected to bootstrapped exploratory graph analysis (EGA), which identifies the dimensions of variables that cluster together. Variables that contributed to the EGA dimensions were used to predict cardiac distress using multivariable logistic regression. Results: Three distinct dimensions were identified by the EGA: Dimension 1 - clinical risk factors and conditions including OSA, Dimension 2 - variables related to the heart event, and Dimension 3 - variables closely related to cardiac distress. For Dimension 1, only OSA was a significant predictor of cardiac distress in the fully adjusted model (adjusted odds ratio = 2.08, 95% confidence interval = 1.02-4.25, P = 0.044). Further analysis indicated that OSA was associated with physical challenges and changes in roles and relationships. Conclusions: This study identified that self-reported OSA is associated with cardiac distress, particularly distress that was associated with physical challenges and changes to roles and relationships. These findings imply that OSA could potentially increase stress in a relationship; however, distress was only assessed from the perspective of the participant with OSA in this study. EGA is a useful method for describing complex associations between diverse predictor variables such as OSA and cardiac distress. Owing to the self-reported aspect of the data, further investigation to confirm study outcomes is warranted.
C1 [Le Grande, Michael R.; Beauchamp, Alison; Jackson, Alun C.] Australian Ctr Heart Hlth, 75 Chetwynd St, North Melbourne, Vic 3051, Australia.
   [Le Grande, Michael R.; Driscoll, Andrea; Kerr, Debra] Deakin Univ Geelong, Sch Nursing & Midwifery, Ctr Qual & Patient Safety Res Inst Hlth Transform, Victoria, Australia.
   [Le Grande, Michael R.; Jackson, Alun C.] Univ Melbourne, Sch Psychol Sci, Parkville, Vic, Australia.
   [Beauchamp, Alison] Monash Univ, Sch Rural Hlth, Warragul, Vic, Australia.
   [Driscoll, Andrea] Monash Hlth, Dept Nursing, Melbourne, Vic, Australia.
   [Jackson, Alun C.] Univ Hong Kong, Ctr Behav Hlth, Pakfulam, Hong Kong, Peoples R China.
C3 Deakin University; University of Melbourne; Monash University; Monash
   Health; University of Hong Kong
RP Le Grande, MR (corresponding author), Australian Ctr Heart Hlth, 75 Chetwynd St, North Melbourne, Vic 3051, Australia.
EM michael.legrande@australianhearthealth.org.au
RI Le Grande, Michael/A-4820-2008; Jackson, Alun/R-6306-2019
FU NHMRC
FX Associate Professor Alison Beauchamp is supported by an NHMRC
   fellowship.
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NR 66
TC 0
Z9 0
U1 1
U2 2
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, Maharashtra, INDIA
SN 2468-6476
EI 2468-6484
J9 HEART MIND
JI Heart Mind
PD JUL-SEP
PY 2024
VL 8
IS 3
BP 228
EP 238
DI 10.4103/hm.HM-D-24-00017
PG 11
WC Cardiac & Cardiovascular Systems; Psychiatry
WE Emerging Sources Citation Index (ESCI)
SC Cardiovascular System & Cardiology; Psychiatry
GA F9G3M
UT WOS:001312811500012
OA gold
DA 2025-06-11
ER

PT J
AU Gutiérrez-Rojas, L
   Azanza, JR
   Bernardo, M
   Rojo, L
   Mesa, F
   Martínez-Ortega, JM
AF Gutierrez-Rojas, Luis
   Azanza, Jose R.
   Bernardo, Miquel
   Rojo, Luis
   Mesa, Francisco
   Martinez-Ortega, Jose M.
TI Prevalence of Metabolic Syndrome in Spanish Patients with Schizophrenia
   and Overweight. The CRESSOB Study
SO ACTAS ESPANOLAS DE PSIQUIATRIA
LA English
DT Article
DE Schizophrenia; Metabolic Syndrome; Overweight; Cardiovascular Disease
ID CLINICAL ANTIPSYCHOTIC TRIALS; CORONARY-HEART-DISEASE; ATYPICAL
   ANTIPSYCHOTICS; CARDIOVASCULAR-DISEASE; DIABETES-MELLITUS;
   BIPOLAR-DISORDER; OUTPATIENTS; REMISSION; RISK; CARE
AB Introduction: Metabolic syndrome (MS) (visceral obesity, dyslipidemia, hyperglycemia, and hypertension), has become one of the major public-health challenges worldwide. Patients with schizophrenia are more likely to suffer from MS than the general population.
   Objective: The primary aim of this study was to analyze the prevalence of MS in Spanish patients with schizophrenia and overweight and to compare the best method to calculate the MS prevalence in this population.
   A secondary aim of the CRESSOB study was to determine whether the presence of the metabolic syndrome (MS) is associated or not with clinical remission of schizophrenia.
   Methods: The Control of Metabolic and Cardiovascular Risk in Patients with Schizophrenia and Overweight (CRESSOB) study is a 12-month, prospective, naturalistic study including 110 community mental health clinics selected at random. Each site enrolled four consecutive patients with a diagnosis of schizophrenia, according to DSM-IV TR criteria, and who were overweight (Body Mass Index (BMI) >25 kg/m(2)). To assess the prevalence of MS we analyzed the baseline results of the CRESSOB study. The National Cholesterol Education Program (NCEP-ATP III), the International Diabetes Federation (IDF) and the American Heart Association/National Heart, Lung, and Blood Institute (AHA/NHLBI) definitions were used to establish the presence of MS. The Positive and Negative Syndrome Scale (PANSS) was used to determine the percentage of patients in remission. Psychosocial functioning was measured by the Global Assessment of Functioning (GAF) scale.
   Results: A total of 391 patients were enrolled in the study (mean age 40.5 years, 63.8% men). 75.9% of the patients did not meet criteria for remission, using the selected PANSS items. The mean GAF score was 52.7 (Standard Deviation (SD) 15.4). Overall, 59.0% of males and 58.3% of females fulfilled the NCEP-ATP III criteria, 71.1% of males and 65.8% of females fulfilled the IDF criteria and 70.1% of males and 65.1% of females fulfilled the AFIA/NHLBI criteria. The patients who fulfilled remission criteria were younger, had a lower BMI, and a higher GAF score.
   Conclusions: MS is highly prevalent in Spanish patients with schizophrenia who are overweight. Given that metabolic syndrome is an important risk factor for cardiovascular disease, these patients should receive appropriate clinical monitoring for this syndrome.
C1 [Gutierrez-Rojas, Luis] San Cecilio Univ Hosp, Psychiat Serv, Granada, Spain.
   [Gutierrez-Rojas, Luis; Martinez-Ortega, Jose M.] Univ Granada, CTS Res Grp 549, Ctr Biomed Res CIBM, Inst Neurosci, E-18071 Granada, Spain.
   [Azanza, Jose R.] Univ Navarra, Univ Hosp, Clin Invest Unit, Navarra, Spain.
   [Bernardo, Miquel] Inst Invest Biomed August Pi & Sunyer IDIBAPS, Barcelona, Spain.
   [Bernardo, Miquel] Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain.
   [Bernardo, Miquel] Hosp Clin Barcelona, Dept Psychiat, Barcelona, Spain.
   [Bernardo, Miquel] Univ Barcelona, Dept Psychiat & Clin Psychobiol, Barcelona, Spain.
   [Rojo, Luis] Hosp La Fe, Psychiat Unit, E-46009 Valencia, Spain.
   [Mesa, Francisco] Pfizer Espana, Dept Neurosci, Med Unit, Madrid, Spain.
C3 Hospital Universitario San Cecilio; University of Granada; University of
   Navarra; University of Barcelona; Hospital Clinic de Barcelona; IDIBAPS;
   CIBER - Centro de Investigacion Biomedica en Red; CIBERSAM; University
   of Barcelona; Hospital Clinic de Barcelona; University of Barcelona;
   Hospital Universitari i Politecnic La Fe; Pfizer; Pfizer Spain
RP Gutiérrez-Rojas, L (corresponding author), Univ Granada, Dept Psychiat, Ctr Biomed Res CIBM, Av Madrid 11, E-18071 Granada, Spain.
EM gutierrezrojasl@hotmail.com
RI Rojas, Luis/B-8732-2013; Mesa, Fredy/E-8730-2016; Azanza Perea, José
   Ramón/ABG-1593-2021; Rojas, Luis/AAI-1110-2021; Bernardo,
   Miquel/P-3049-2015
OI Bernardo, Miquel/0000-0001-8748-6717; Gutierrez-Rojas,
   Luis/0000-0003-0082-2189; Azanza Perea, Jose Ramon/0000-0003-3190-622X
FU Pfizer; Government of Catalonia; Comissionat per Universitats i Recerca
   del Departament d'Innovacio, Universitats i Empresa (DIUE)
   [2009SGR1295]; Instituto de Salud Carlos III, Centro de Investigacion
   Biomedica en Red de Salud Mental, CIBERSAM
FX This study was sponsored by Pfizer. Pfizer contributed to and approved
   the study design and the final draft of the manuscript. A CRO was
   engaged by Pfizer to conduct the study, including logistics, monitoring,
   data management, and statistical analysis. Pfizer oversaw the entire
   process of the study. Supported in part by the Government of Catalonia,
   Comissionat per Universitats i Recerca del Departament d'Innovacio,
   Universitats i Empresa (DIUE) 2009SGR1295, and by the Instituto de Salud
   Carlos III, Centro de Investigacion Biomedica en Red de Salud Mental,
   CIBERSAM
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NR 56
TC 12
Z9 14
U1 0
U2 20
PU JUAN JOSE LOPEZ-IBOR FOUNDATION
PI MADRID
PA NO 2, MADRID, 28035, SPAIN
SN 1139-9287
EI 1578-2735
J9 ACTAS ESP PSIQUIATRI
JI Actas Esp. Psiquiatri.
PD JAN-FEB
PY 2014
VL 42
IS 1
BP 9
EP 17
PG 9
WC Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA AD3KT
UT WOS:000333138700002
PM 24504989
DA 2025-06-11
ER

PT J
AU Rojas-Gutierrez, E
   Muñoz-Arenas, G
   Treviño, S
   Espinosa, B
   Chavez, R
   Rojas, K
   Flores, G
   Díaz, A
   Guevara, J
AF Rojas-Gutierrez, Eduardo
   Munoz-Arenas, Guadalupe
   Trevino, Samuel
   Espinosa, Blanca
   Chavez, Raul
   Rojas, Karla
   Flores, Gonzalo
   Diaz, Alfonso
   Guevara, Jorge
TI Alzheimer's disease and metabolic syndrome: A link from oxidative stress
   and inflammation to neurodegeneration
SO SYNAPSE
LA English
DT Review
DE Alzheimer; amyloid-beta; diabetes; free radicals; glucose; metabolic
   syndrome; neurodegeneration; oxidative stress; tau
ID INSULIN-DEGRADING ENZYME; GLYCATION END-PRODUCTS; MILD COGNITIVE
   IMPAIRMENT; CEREBRAL GLUCOSE-METABOLISM; BLOOD-BRAIN-BARRIER;
   GROWTH-FACTOR-I; NF-KAPPA-B; AMYLOID PRECURSOR PROTEIN; A-BETA PEPTIDE;
   ENERGY-METABOLISM
AB Alzheimer's disease (AD) is the most common cause of dementia and one of the most important causes of morbidity and mortality among the aging population. AD diagnosis is made post-mortem, and the two pathologic hallmarks, particularly evident in the end stages of the illness, are amyloid plaques and neurofibrillary tangles. Currently, there is no curative treatment for AD. Additionally, there is a strong relation between oxidative stress, metabolic syndrome, and AD. The high levels of circulating lipids and glucose imbalances amplify lipid peroxidation that gradually diminishes the antioxidant systems, causing high levels of oxidative metabolism that affects cell structure, leading to neuronal damage. Accumulating evidence suggests that AD is closely related to a dysfunction of both insulin signaling and glucose metabolism in the brain, leading to an insulin-resistant brain state. Four drugs are currently used for this pathology: Three FDA-approved cholinesterase inhibitors and one NMDA receptor antagonist. However, wide varieties of antioxidants are promissory to delay or prevent the symptoms of AD and may help in treating the disease. Therefore, therapeutic efforts to achieve attenuation of oxidative stress could be beneficial in AD treatment, attenuating A-induced neurotoxicity and improve neurological outcomes in AD. The term inflammaging characterizes a widely accepted paradigm that aging is accompanied by a low-grade chronic up-regulation of certain pro-inflammatory responses in the absence of overt infection, and is a highly significant risk factor for both morbidity and mortality in the elderly.
C1 [Rojas-Gutierrez, Eduardo; Chavez, Raul; Rojas, Karla; Guevara, Jorge] Univ Nacl Autonoma Mexico, Fac Med, Dept Bioquim, Ciudad De Mexico 04510, Mexico.
   [Munoz-Arenas, Guadalupe; Trevino, Samuel; Diaz, Alfonso] Benemerita Univ Autonoma Puebla, Fac Ciencias Quim, Puebla, Pue, Mexico.
   [Espinosa, Blanca] INER, Dept Bioquim, Ciudad De Mexico, Mexico.
   [Flores, Gonzalo] Benemerita Univ Autonoma Puebla, Inst Fisiol, Puebla, Pue, Mexico.
C3 Universidad Nacional Autonoma de Mexico; Benemerita Universidad Autonoma
   de Puebla; Benemerita Universidad Autonoma de Puebla
RP Guevara, J (corresponding author), Univ Nacl Autonoma Mexico, Fac Med, Dept Bioquim, Ciudad De Mexico 04510, Mexico.
EM jorge.guevara@comunidad.unam.mx
RI Rojas, Karla/HCI-4058-2022; Flores, Gonzalo/B-1807-2014
OI Diaz, Alfonso/0000-0003-4092-6636; Flores, Gonzalo/0000-0002-4100-2104;
   Rojas Gutierrez, Eduardo/0000-0003-3551-2455
FU VIEP-BUAP [DIFA-NAT17-I]; PAPIT-UNAM [IN214117]
FX VIEP-BUAP, Grant/Award number: DIFA-NAT17-I; PAPIT-UNAM, Grant/Award
   number: IN214117.
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NR 311
TC 147
Z9 154
U1 1
U2 110
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0887-4476
EI 1098-2396
J9 SYNAPSE
JI Synapse
PD OCT
PY 2017
VL 71
IS 10
AR e21990
DI 10.1002/syn.21990
PG 21
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology
GA FE6JZ
UT WOS:000408317100003
PM 28650104
DA 2025-06-11
ER

PT J
AU Demirtas, CY
   Pasaoglu, OT
   Bircan, FS
   Kantar, S
   Turkozkan, N
AF Demirtas, C. Y.
   Pasaoglu, O. T.
   Bircan, F. S.
   Kantar, S.
   Turkozkan, N.
TI The investigation of melatonin effect on liver antioxidant and oxidant
   levels in fructose-mediated metabolic syndrome model
SO EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
LA English
DT Article
DE Melatonin; Metabolic syndrome; Fructose; Oxidative stress; Liver
ID OXIDATIVE STRESS; INSULIN-RESISTANCE; GLUTATHIONE-PEROXIDASE; SWEETENED
   BEVERAGES; GENE-EXPRESSION; BLOOD-PRESSURE; POTENTIAL ROLE; RAT-BRAIN;
   HYPERTENSION; PARAOXONASE
AB OBJECTIVE: Metabolic syndrome (MetS) can be induced by the oxidative stress conditions caused by ingestion of large amounts of fructose. We investigated the possible protective effects of melatonin administration on liver tissues in fructose-fed rats.
   MATERIALS AND METHODS: Thirty-two rats were randomly divided into four groups; control, fructose, melatonin, and fructose plus melatonin. MetS was induced by a fructose solution (20% in tap water) and melatonin (20 mg/kg daily) was administered by oral gavage. Systolic blood pressures (SBP) were measured. After the end of the 8-week experimental period, serum lipid profile, glucose and insulin levels, tissue total oxidant status (TOS) and activities of paraoxonase (PON), glutathione peroxidase (GSH-Px), superoxide dismutase (SOD) and catalase (CAT) were measured.
   RESULTS: Fructose consumption significantly increased SBP, serum triglyceride and insulin levels and induced insulin resistance, confirming successful establishment of the MetS model. After fructose administration, the TOS levels and GSH-Px activities significantly increased in all groups compared to the control group. The PON activity in the fructose group significantly decreased compared to the control group. Melatonin supplementation, with or without fructose, increased PON activity. The SOD activity significantly increased in the fructose group compared to the control group, but significantly decreased in the melatonin group compared to the control and fructose groups. CAT activity was unchanged in all groups.
   CONCLUSIONS: GSH-PX and PON are important antioxidants for reducing oxidant stress. Melatonin might act as a prooxidant at the dose given in our experimental design when administered with fructose.
C1 [Demirtas, C. Y.; Pasaoglu, O. T.; Kantar, S.; Turkozkan, N.] Gazi Univ, Fac Med, Dept Biochem, Ankara, Turkey.
   [Bircan, F. S.] Gazi Univ, Fac Med, Dept Biol, Ankara, Turkey.
C3 Gazi University; Gazi University
RP Demirtas, CY (corresponding author), Gazi Univ, Fac Med, Dept Biochem, Ankara, Turkey.
EM mdcanandemirtas@yahoo.com.tr
RI Pasaoglu, Ozge/AAZ-5223-2020; Yılmaz, Canan/AAT-7788-2020
OI Bircan, Filiz Sezen/0000-0002-1007-2484; YILMAZ,
   CANAN/0000-0002-6799-6522
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NR 44
TC 22
Z9 23
U1 0
U2 14
PU VERDUCI PUBLISHER
PI ROME
PA VIA GREGORIO VII, ROME, 186-00165, ITALY
SN 1128-3602
J9 EUR REV MED PHARMACO
JI Eur. Rev. Med. Pharmacol. Sci.
PD MAY
PY 2015
VL 19
IS 10
BP 1915
EP 1921
PG 7
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA CJ9GW
UT WOS:000355811500028
PM 26044240
DA 2025-06-11
ER

PT J
AU Wolf, EJ
   Miller, DR
   Logue, MW
   Sumner, J
   Stoop, TB
   Leritz, EC
   Hayes, JP
   Stone, A
   Schichman, SA
   McGlinchey, RE
   Milberg, WP
   Miller, MW
AF Wolf, Erika J.
   Miller, Danielle R.
   Logue, Mark W.
   Sumner, Jennifer
   Stoop, Tawni B.
   Leritz, Elizabeth C.
   Hayes, Jasmeet P.
   Stone, Annjanette
   Schichman, Steven A.
   McGlinchey, Regina E.
   Milberg, William P.
   Miller, Mark W.
TI Contributions of polygenic risk for obesity to PTSD-related metabolic
   syndrome and cortical thickness
SO BRAIN BEHAVIOR AND IMMUNITY
LA English
DT Article
DE Metabolic syndrome; Obesity; Cortical thickness; Polygenic risk;
   Magnetic resonance imaging; Posttraumatic stress disorder; Accelerated
   aging
ID POSTTRAUMATIC-STRESS-DISORDER; WHITE-MATTER INTEGRITY; BODY-MASS INDEX;
   INHIBITORY CONTROL; FOLLOW-UP; ASSOCIATION; COMPONENTS; PEOPLE;
   METAANALYSIS; METHYLATION
AB Background: Research suggests that posttraumatic stress disorder (PTSD) is associated with metabolic syndrome (MetS) and that PTSD-associated MetS is related to decreased cortical thickness. However, the role of genetic factors in these associations is unclear. This study evaluated contributions of polygenic obesity risk and PTSD to MetS and of MetS and polygenic obesity risk to cortical thickness.
   Methods: 196 white, non-Hispanic veterans of the wars in Iraq and Afghanistan underwent clinical diagnostic interviews, physiological assessments, and genome-wide genotyping; 168 also completed magnetic resonance imaging scans. Polygenic risk scores (PRSs) for obesity were calculated from results of a prior genome-wide association study (Speliotes et al., 2010) and PTSD and MetS severity factor scores were obtained.
   Results: Obesity PRS (beta = 0.15, p = 0.009) and PTSD (beta = 0.17, p = 0.005) predicted MetS and interacted such that the association between PTSD and MetS was stronger in individuals with greater polygenic obesity risk (beta = 0.13, p = 0.02). Whole-brain vertex-wise analyses suggested that obesity PRS interacted with MetS to predict decreased cortical thickness in left rostral middle frontal gyrus (beta = 0.40, p < 0.001).
   Conclusions: Results suggest that PTSD, genetic variability, and MetS are related in a transactional fashion wherein obesity genetic risk increases stress-related metabolic pathology, and compounds the ill health effects of MetS on the brain. Genetic proclivity towards MetS should be considered in PTSD patients when prescribing psychotropic medications with adverse metabolic profiles. Results are consistent with a growing literature suggestive of PTSD-related accelerated aging. Published by Elsevier Inc.
C1 [Wolf, Erika J.; Miller, Danielle R.; Logue, Mark W.; Hayes, Jasmeet P.; Miller, Mark W.] VA Boston Healthcare Syst, Behav Sci Div, Natl Ctr PTSD, Boston, MA USA.
   [Wolf, Erika J.; Miller, Danielle R.; Hayes, Jasmeet P.; Miller, Mark W.] Boston Univ, Sch Med, Dept Psychiat, Boston, MA 02118 USA.
   [Logue, Mark W.] Boston Univ, Sch Med, Biomed Genet, Boston, MA 02118 USA.
   [Logue, Mark W.] Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA USA.
   [Sumner, Jennifer] Columbia Univ, Med Ctr, Ctr Behav Cardiovasc Hlth, New York, NY USA.
   [Stoop, Tawni B.] VA Boston Healthcare Syst, Res Serv, Boston, MA USA.
   [Leritz, Elizabeth C.; Hayes, Jasmeet P.] VA Boston Healthcare Syst, Neuroimaging Res Vet Ctr, Boston, MA USA.
   [Leritz, Elizabeth C.; McGlinchey, Regina E.; Milberg, William P.] VA Boston Healthcare Syst, Geriatr Res Educ & Clin Ctr, Boston, MA USA.
   [Leritz, Elizabeth C.; McGlinchey, Regina E.; Milberg, William P.] VA Boston Healthcare Syst, Translat Res Ctr TBI & Stress Disorders, Boston, MA USA.
   [Leritz, Elizabeth C.; McGlinchey, Regina E.; Milberg, William P.] Harvard Med Sch, Dept Psychiat, Boston, MA USA.
   [Stone, Annjanette; Schichman, Steven A.] Cent Arkansas Vet Healthcare Syst, Res Serv, Pharmacogen Anal Lab, Little Rock, AR USA.
C3 Harvard University; Harvard University Medical Affiliates; US Department
   of Veterans Affairs; Veterans Health Administration (VHA); VA Boston
   Healthcare System; Boston University; Boston University; Boston
   University; Columbia University; Harvard University; Harvard University
   Medical Affiliates; US Department of Veterans Affairs; Veterans Health
   Administration (VHA); VA Boston Healthcare System; Harvard University;
   Harvard University Medical Affiliates; US Department of Veterans
   Affairs; Veterans Health Administration (VHA); VA Boston Healthcare
   System; Harvard University; Harvard University Medical Affiliates; US
   Department of Veterans Affairs; Veterans Health Administration (VHA); VA
   Boston Healthcare System; Geriatric Research Education & Clinical
   Center; Harvard University; Harvard University Medical Affiliates; US
   Department of Veterans Affairs; Veterans Health Administration (VHA); VA
   Boston Healthcare System; Harvard University; Harvard Medical School; US
   Department of Veterans Affairs; Veterans Health Administration (VHA);
   Central Arkansas Veterans Healthcare System
RP Wolf, EJ (corresponding author), VA Boston Healthcare Syst, Natl Ctr PTSD 116B 2, 150 S Huntington Ave, Boston, MA 02130 USA.
EM erika.wolf@va.gov
RI Hayes, Jasmeet/AAN-4150-2020; McGlinchey, Regina/R-1971-2016; Sumner,
   Jennifer/AAT-3319-2021; Miller, Mark/G-7322-2011
OI Sullivan, Danielle R./0000-0002-0141-5887; Miller,
   Mark/0000-0001-6393-8563; Wolf, Erika/0000-0003-2666-2435
FU NIMH [R21MH102834, T32MH019836-01]; Translational Research Center for
   TBI and Stress Disorders (TRACTS); VA Rehabilitation Research and
   Development Traumatic Brain Injury Center of Excellence [B9254-C]; VA
   SPiRe award [121RX001594]; Cooperative Studies Program, Department of
   Veterans Affairs, NINDS [R01NS086882]; National Institute On Aging of
   the National Institutes of Health [R03AG051877]; Presidential Early
   Career Award for Scientists and Engineers (PECASE); National Heart,
   Lung, and Blood Award [K01HL130650]; National Center for PTSD at VA
   Boston Healthcare System
FX This research was supported in part by NIMH grant R21MH102834
   "Neuroimaging Genetics of PTSD" to Mark Miller and the Translational
   Research Center for TBI and Stress Disorders (TRACTS), a VA
   Rehabilitation Research and Development Traumatic Brain Injury Center of
   Excellence (B9254-C), VA SPiRe award 121RX001594 to Jasmeet Hayes, and
   the Cooperative Studies Program, Department of Veterans Affairs, NINDS
   grant R01NS086882, and NIMH training grant (T32MH019836-01) awarded to
   Terence Keane, Ph.D., National Center for PTSD at VA Boston Healthcare
   System supporting DRM. Research reported in this publication was also
   supported by the National Institute On Aging of the National Institutes
   of Health under Award Number R03AG051877 to Erika Wolf, by a
   Presidential Early Career Award for Scientists and Engineers (PECASE) to
   Erika Wolf as administered by U.S. Department of Veterans Affairs (VA)
   Office of Research and Development (PECASE 2013A), and by a National
   Heart, Lung, and Blood Award (K01HL130650) to Jennifer Sumner. This
   research is the result of work supported with resources and the use of
   facilities at the Pharmacogenomics Analysis Laboratory, Research and
   Development Service, Central Arkansas Veterans Healthcare System, Little
   Rock, Arkansas, National Center for PTSD, and the Neuroimaging Research
   for Veterans Center, VA Boston Healthcare System. The views expressed in
   this article are those of the authors and do not necessarily reflect the
   position or policy of the Department of Veterans Affairs or the United
   States Government.
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NR 55
TC 25
Z9 27
U1 0
U2 10
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0889-1591
EI 1090-2139
J9 BRAIN BEHAV IMMUN
JI Brain Behav. Immun.
PD OCT
PY 2017
VL 65
BP 328
EP 336
DI 10.1016/j.bbi.2017.06.001
PG 9
WC Immunology; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Neurosciences & Neurology; Psychiatry
GA FC6YD
UT WOS:000406986700031
PM 28579519
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Iwanaga, S
   Sakano, N
   Taketa, K
   Takahashi, N
   Wang, DH
   Takahashi, H
   Kubo, M
   Miyatake, N
   Ogino, K
AF Iwanaga, Suketaka
   Sakano, Noriko
   Taketa, Kazuhisa
   Takahashi, Noriko
   Wang, Da-Hong
   Takahashi, Hidekazu
   Kubo, Masayuki
   Miyatake, Nobuyuki
   Ogino, Keiki
TI Comparison of serum ferritin and oxidative stress biomarkers between
   Japanese workers with and without metabolic syndrome
SO OBESITY RESEARCH & CLINICAL PRACTICE
LA English
DT Article
DE Oxidative stress; Ferritin; 8-Hydroxy-2 '-deoxyguanosine (8-OHdG);
   Hydrogen peroxide (H2O2); Metabolic syndrome
ID C-REACTIVE PROTEIN; BODY IRON STORES; INSULIN-RESISTANCE; HEALTHY
   PEOPLE; DNA-DAMAGE; POPULATION; WOMEN; 8-HYDROXYDEOXYGUANOSINE;
   INFLAMMATION; ASSOCIATION
AB Objective: Metabolic syndrome (MS) is closely associated to life-style and is characterized by central obesity causing severe diseases such as diabetes mellitus (DM) or atherosclerosis. This study investigates the role of oxidative stress and inflammation in MS. Subjects: Total of 685 workers stratified by gender (293 men and 392 women) with a mean age of 41.2 +/- 10.4 in different offices in a city in Japan.
   Methods: Fasting blood and urine tests for MS, oxidative and/or inflammatory biomarker analysis and blood pressure (BP) measurement were performed. MS was defined on the basis of the Japanese criterion.
   Results: Serum ferritin and urinary hydrogen peroxide (H2O2) levels were significantly higher in subjects with MS than those without. Ferritin was positively correlated with 8-hydroxy-2'-deoxyguanosine (8-OHdG) in all subjects and it was negatively correlated with 8-isoprostane and H2O2 in men. In addition, there was a significant positive correlation between ferritin and homeostasis model assessment (HOMA-R) in men. By using multiple regression analysis, ferritin was closely correlated with HOMA-R, gamma-GT, 8-OHdG, smoking value and amount of alcohol ingestion in men, and it was correlated with 8-OHdG, gamma-GT, HOMA-R in women under 50 years old.
   Conclusions: Ferritin is a useful marker of MS including insulin resistance, reflecting the importance of oxidative stress as a cause of MS, especially in men. (C) 2013 Asian Oceanian Association for the Study of Obesity. Published by Elsevier Ltd. All rights reserved.
C1 [Iwanaga, Suketaka] Kyoto Univ, Fac Med, Dept Publ Hlth, Kyoto 6068501, Japan.
   [Sakano, Noriko; Miyatake, Nobuyuki] Kagawa Univ, Dept Hyg, Fac Med, Kagawa 7610793, Japan.
   [Taketa, Kazuhisa] Geriatr Hlth Serv Facil, Mihara, Hiroshima 7291321, Japan.
   [Taketa, Kazuhisa; Takahashi, Noriko; Wang, Da-Hong; Takahashi, Hidekazu; Kubo, Masayuki; Ogino, Keiki] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Publ Hlth, Okayama 7008558, Japan.
C3 Kyoto University; Kagawa University; Okayama University
RP Ogino, K (corresponding author), Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Publ Hlth, 2-5-1 Shikata Cho, Okayama 7008558, Japan.
EM kogino@md.okayama-u.ac.jp
FU Junpukai; Health Science Center Foundation; Grants-in-Aid for Scientific
   Research [23390163, 26293152] Funding Source: KAKEN
FX This research was supported in part by funding from the Junpukai and in
   part from Health Science Center Foundation. We gratefully acknowledge
   the technical contribution from B. Wang, S. Rani, A. Miura, A. Horii,
   and T. Mitsumune.
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NR 35
TC 14
Z9 14
U1 0
U2 11
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1871-403X
EI 1878-0318
J9 OBES RES CLIN PRACT
JI Obes. Res. Clin. Pract.
PD MAY-JUN
PY 2014
VL 8
IS 3
BP E271
EP E282
DI 10.1016/j.orcp.2013.01.003
PG 12
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA AG8JB
UT WOS:000335663500009
PM 24847669
DA 2025-06-11
ER

PT J
AU Renke, G
   Kemen, E
   Scalabrin, P
   Braz, C
   Baêsso, T
   Pereira, MB
AF Renke, Guilherme
   Kemen, Elaine
   Scalabrin, Priscila
   Braz, Cleibe
   Baesso, Thomaz
   Pereira, Marcela Batista
TI Cardio-Metabolic Health and HRT in Menopause: Novel Insights in
   Mitochondrial Biogenesis and RAAS
SO CURRENT CARDIOLOGY REVIEWS
LA English
DT Review
DE Menopause; cardiometabolic risk factor; hormone replacement therapy;
   estrogen replacement therapy; mitochondria; renin-angiotensin system
ID ESTROGEN; RECEPTOR
AB Recent evidence shows the cardiometabolic effects of estrogen administration in postmenopausal women. Women have a cardiometabolic advantage during their reproductive years, which is lost at menopause due to declining estradiol (E2). E2, also known as 17-beta-estradiol, has diverse effects in its target tissues, including the cardiovascular (CV) system, through genomic and non-genomic signaling. Metabolic changes characteristic of menopause include a worsening lipid profile, changes in body fat distribution, epicardial and pericardial fat deposition, increased susceptibility to weight gain, and increased blood pressure, resulting in an increased risk of accelerated cardiovascular disease (CVD) development. E2 mediates its cardioprotective actions by increasing mitochondrial biogenesis, angiogenesis, and vasodilation, decreasing reactive oxygen species (ROS) and oxidative stress, and modulating the renin-angiotensin-aldosterone system (RAAS). In this review, we assess whether it is prudent to develop an approach to managing postmenopausal women based on modifying the patient's CV risk that includes human-identical hormone replacement therapy (HRT), modulation of RAAS, and stimulating mitochondrial biogenesis. Further research is needed to assess the safety and benefit of HRT to reduce cardiometabolic risk.
C1 [Renke, Guilherme] Brazilian Minist Hlth, Natl Inst Cardiol, Rio De Janeiro, Brazil.
   [Renke, Guilherme; Kemen, Elaine; Scalabrin, Priscila; Braz, Cleibe; Baesso, Thomaz; Pereira, Marcela Batista] Nutrindo Ideais Performance & Nutr Res Ctr, Rio De Janeiro, Brazil.
RP Renke, G (corresponding author), Brazilian Minist Hlth, Natl Inst Cardiol, Rio De Janeiro, Brazil.; Renke, G (corresponding author), Nutrindo Ideais Performance & Nutr Res Ctr, Rio De Janeiro, Brazil.
EM renke@renke.com.br
RI Renke, Guilherme/JKJ-2777-2023
OI Renke, Guilherme/0000-0002-7940-3667
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NR 27
TC 5
Z9 5
U1 0
U2 2
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1573-403X
EI 1875-6557
J9 CURR CARDIOL REV
JI Curr. Cardiol. Rev.
PY 2023
VL 19
IS 4
AR e060223213459
DI 10.2174/1573403X19666230206130205
PG 5
WC Cardiac & Cardiovascular Systems
WE Emerging Sources Citation Index (ESCI)
SC Cardiovascular System & Cardiology
GA N1CR2
UT WOS:001034482300007
PM 36748220
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Lee, C
   Tsenkova, V
   Carr, D
AF Lee, Chioun
   Tsenkova, Vera
   Carr, Deborah
TI Childhood trauma and metabolic syndrome in men and women
SO SOCIAL SCIENCE & MEDICINE
LA English
DT Article
DE Stress; Childhood trauma; Sex; Metabolic syndrome; Coping; Life course
ID ADULT RETROSPECTIVE REPORTS; MIDDLE-AGED WOMEN; SEXUAL-ABUSE;
   CARDIOVASCULAR-DISEASE; PHYSICAL ABUSE; LEADING CAUSES; SLEEP PROBLEMS;
   HEART-DISEASE; RISK-FACTORS; HEALTH
AB The long-term effects of childhood trauma on health are well-documented, but few population-based studies have explored how childhood trauma affects the risk of developing metabolic syndrome (MetS) in adulthood. Using data from 1234 adults in the second wave of Midlife in the United States (MIDUS), we investigate (1) the extent to which childhood abuse affects the risk of developing MetS in adulthood; (2) how the severity of different types of abuse (emotional, physical, sexual, or cumulative abuse) affects this risk; and (3) the extent to which adult socioeconomic status (SES), maladaptive stress responses, and unhealthy behaviors mediate the association. We also test whether these associations differ significantly by sex. We find that emotional and physical abuse increase the risk of developing MetS for both sexes, whereas sexual abuse is a predictor for women only. For both sexes, individuals who experienced more cumulative abuse have a greater risk of developing MetS. Adult SES partially explains the association between childhood abuse and MetS. Maladaptive stress responses and unhealthy behaviors further explain the association. Among the potential mediators, poor sleep quality was a significant pathway for men and women, while stress-induced eating was a significant pathway for women only. Our findings suggest that the well-documented health consequences of early life trauma may vary by the nature of the trauma, the victim's sex, and the coping mechanisms that he or she employs. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Lee, Chioun] Princeton Univ, Off Populat Res, Princeton, NJ 08544 USA.
   [Tsenkova, Vera] Univ Wisconsin, Inst Aging, Madison, WI USA.
   [Carr, Deborah] Rutgers State Univ, Dept Sociol, New Brunswick, NJ 08903 USA.
   [Carr, Deborah] Rutgers State Univ, Inst Hlth Hlth Care Policy & Aging Res, New Brunswick, NJ 08903 USA.
C3 Princeton University; University of Wisconsin System; University of
   Wisconsin Madison; Rutgers University System; Rutgers University New
   Brunswick; Rutgers University System; Rutgers University New Brunswick
RP Lee, C (corresponding author), Princeton Univ, Off Populat Res, 261 Wallace Hall, Princeton, NJ 08544 USA.
EM chiounl@princeton.edu
RI Carr, Deborah/AAT-4078-2020
OI Lee, Chioun/0000-0002-6886-8397
FU NIA NIH HHS [K01 AG041179, P01 AG020166] Funding Source: Medline
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NR 64
TC 103
Z9 118
U1 1
U2 22
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0277-9536
J9 SOC SCI MED
JI Soc. Sci. Med.
PD MAR
PY 2014
VL 105
BP 122
EP 130
DI 10.1016/j.socscimed.2014.01.017
PG 9
WC Public, Environmental & Occupational Health; Social Sciences, Biomedical
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; Biomedical Social Sciences
GA AF1LW
UT WOS:000334476400015
PM 24524907
OA Green Accepted, Green Published
DA 2025-06-11
ER

PT J
AU Sheikhansari, G
   Soltani-Zangbar, MS
   Pourmoghadam, Z
   Kamrani, A
   Azizi, R
   Aghebati-Maleki, L
   Danaii, S
   Koushaeian, L
   Hojat-Farsangi, M
   Yousefi, M
AF Sheikhansari, Golshan
   Soltani-Zangbar, Mohammad Sadegh
   Pourmoghadam, Zahra
   Kamrani, Amin
   Azizi, Ramyar
   Aghebati-Maleki, Leili
   Danaii, Shahla
   Koushaeian, Ladan
   Hojat-Farsangi, Mohammad
   Yousefi, Mehdi
TI Oxidative stress, inflammatory settings, and microRNA regulation in the
   recurrent implantation failure patients with metabolic syndrome
SO AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
LA English
DT Article
DE inflammatory factors; metabolic syndrome; microRNA; oxidative stress;
   oxidative stress markers; recurrent implantation failure
ID EARLY-PREGNANCY; IMMUNE-SYSTEM; INSULIN-RESISTANCE; PERIPHERAL-BLOOD;
   ADIPOSE-TISSUE; OBESITY; EXPRESSION; DISEASE; CELLS; ASSOCIATION
AB Problem Increased oxidative stress (OS) and inflammatory factors in metabolic syndrome (MS) patients are considered as risk factors for recurrent implantation failure (RIF). The aim of this study was to investigate OS markers, inflammatory factors, related microRNAs (miRNA) expression, and cytokine and transcription factors RNA expression. Method of study We evaluated the frequency of helper T (Th) 17 and regulatory T (Treg) cells in recurrent implantation failure (RIF) women with or without MS. miRNA expression, an inflammatory cytokine, and transcription factors were measured by real-time PCR. The level of interleukin (IL)-1 beta, IL-6, IL-17, tumour necrosis factor-alpha (TNF-alpha) and chemokine (C-C motif) ligand 2 (CCL-2), and C-X-C motif chemokine ligand 8 (CXCL-8) were measured by enzyme-linked immunosorbent assay (ELISA). OS markers were evaluated by spectrophotometric assay. Th17 and Treg cell frequencies were determined by flow cytometry. Results The expression of AP1, NF-kappa B, FOXP3, miRNA-21; serum or plasma level of OS markers (ie, nitric oxide, total oxidant status, and myeloperoxidase); serum level of inflammatory factors (ie, IL1-beta, IL-6, IL-17, TNF-alpha, CXCL-8, and CCL-2); and frequency of Th17 cells were increased in RIF-MS patients in comparison with RIF women without MS (RIF-NMS) and control group. The expression of miRNA-223 and 146a, antioxidant enzymes, namely superoxide dismutase (SOD) and catalase (CAT), and frequency of Treg also declined in RIF-MS patients. Conclusion Overall, our findings suggest that MS in RIF patients causes increased inflammatory factors and OS, which in turn leads to implantation failure.
C1 [Sheikhansari, Golshan; Pourmoghadam, Zahra] Tabriz Univ Med Sci, Aging Res Inst, Tabriz, Iran.
   [Sheikhansari, Golshan] Tabriz Univ Med Sci, Student Res Comm, Tabriz, Iran.
   [Soltani-Zangbar, Mohammad Sadegh; Yousefi, Mehdi] Tabriz Univ Med Sci, Stem Cell Res Ctr, Tabriz, Iran.
   [Kamrani, Amin; Azizi, Ramyar; Aghebati-Maleki, Leili; Yousefi, Mehdi] Tabriz Univ Med Sci, Dept Immunol, Fac Med, Tabriz, Iran.
   [Danaii, Shahla] Eastern Azerbaijan ACECR ART Ctr, Eastern Azerbaijan Branch ACECR, Gynecol Dept, Tabriz, Iran.
   [Koushaeian, Ladan] Tabriz Univ Med Sci, Womens Reprod Hlth Res Ctr, Tabriz, Iran.
   [Hojat-Farsangi, Mohammad] Karolinska Univ Hosp Solna, CCK, Dept Oncol Pathol, Immune & Gene Therapy Lab, Stockholm, Sweden.
   [Hojat-Farsangi, Mohammad] Karolinska Inst, Stockholm, Sweden.
C3 Tabriz University of Medical Science; Tabriz University of Medical
   Science; Tabriz University of Medical Science; Tabriz University of
   Medical Science; Tabriz University of Medical Science; Karolinska
   Institutet; Karolinska University Hospital; Karolinska Institutet
RP Yousefi, M (corresponding author), Tabriz Univ Med Sci, Dept Immunol, Fac Med, Tabriz, Iran.
EM Yousefime@tbzmed.ac.ir
RI Soltani-Zangbar, Mohammad Sadegh/AAC-2625-2022; Azizi,
   Ramyar/AFR-5747-2022; Aghebati Maleki, Leili/AAD-9398-2022;
   pourmoghadam, zahra/AAR-9828-2021; yousefi, mehdi/HHZ-3147-2022; Hojat
   Farsangi, Mohammad/E-8171-2018
OI Pourmoghadam, Zahra/0000-0002-0574-7416; Yousefi,
   Mehdi/0000-0003-0099-6728; Hojat Farsangi, Mohammad/0000-0002-0589-5523;
   azizi, ramyar/0000-0003-1754-922X; Soltani-Zangbar, Mohammad
   Sadegh/0000-0003-3960-5712; Danaii, Shahla/0000-0002-2800-1975
FU Stem Cell Research Center at Tabriz University of Medical Sciences, Iran
   [59660]
FX Stem Cell Research Center at Tabriz University of Medical Sciences,
   Iran, Grant/Award Number: 59660
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NR 64
TC 40
Z9 42
U1 0
U2 9
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1046-7408
EI 1600-0897
J9 AM J REPROD IMMUNOL
JI Am. J. Reprod. Immunol.
PD OCT
PY 2019
VL 82
IS 4
AR e13170
DI 10.1111/aji.13170
EA AUG 2019
PG 12
WC Immunology; Reproductive Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Reproductive Biology
GA IX9IQ
UT WOS:000480902000001
PM 31310689
DA 2025-06-11
ER

PT J
AU Liu, C
   Xu, XL
   He, X
   Ren, JY
   Chi, MX
   Deng, G
   Li, GS
   Nasser, MI
AF Liu, Chi
   Xu, Xingli
   He, Xing
   Ren, Junyi
   Chi, Mingxuan
   Deng, Gang
   Li, Guisen
   Nasser, Moussa Ide
TI Activation of the Nrf-2/HO-1 signalling axis can alleviate metabolic
   syndrome in cardiovascular disease
SO ANNALS OF MEDICINE
LA English
DT Review
DE Metabolic syndrome; cardiovascular diseases; Nrf2/HO-1; reactive oxygen
   stress; mitochondrial
ID ERYTHROID 2-RELATED FACTOR-2; HEME OXYGENASE-1 EXPRESSION; INDUCED
   CARDIAC-HYPERTROPHY; OXIDATIVE STRESS; CARBON-MONOXIDE; CROSS-TALK;
   MOLECULAR-MECHANISMS; CELLULAR DEFENSE; DOWN-REGULATION; NITRIC-OXIDE
AB Background: Cardiovascular disease (CVD) is widely observed in modern society. CVDs are responsible for the majority of fatalities, with heart attacks and strokes accounting for approximately 80% of these cases. Furthermore, a significant proportion of these deaths, precisely one-third, occurs in individuals under 70. Metabolic syndrome encompasses a range of diseases characterized by various physiological dysfunctions. These include increased inflammation in adipose tissue, enhanced cholesterol synthesis in the liver, impaired insulin secretion, insulin resistance, compromised vascular tone and integrity, endothelial dysfunction, and atheroma formation. These factors contribute to the development of metabolic disorders and significantly increase the likelihood of experiencing cardiovascular complications.Method: We selected studies that proposed hypotheses regarding metabolic disease syndrome and cardiovascular disease (CVD) and the role of Nrf2/HO-1 and factor regulation in CVD research investigations based on our searches of Medline and PubMed.Results: A total of 118 articles were included in the review, 16 of which exclusively addressed hypotheses about the role of Nrf2 on Glucose regulation, while 16 involved Cholesterol regulation. Likewise, 14 references were used to prove the importance of mitochondria on Nrf2. Multiple studies have provided evidence suggesting the involvement of Nrf2/HO-1 in various physiological processes, including metabolism and immune response. A total of 48 research articles and reviews have been used to highlight the role of metabolic syndrome and CVD.Conclusion: This review provides an overview of the literature on Nrf2/HO-1 and its role in metabolic disease syndrome and CVD.
C1 [Liu, Chi; Chi, Mingxuan; Li, Guisen] Univ Elect Sci & Technol, Sichuan Prov Peoples Hosp, Sichuan Clin Res Ctr Kidney Dis, Dept Nephrol, Chengdu, Peoples R China.
   [Liu, Chi; Chi, Mingxuan; Li, Guisen] Chinese Acad Sci, Sichuan Translat Med Res Hosp, Chengdu, Peoples R China.
   [Xu, Xingli] Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Ultrasound Cardiac Electrophysiol & Biomech Key La, Chengdu, Peoples R China.
   [He, Xing] Chengdu Med Coll, Sch Clin Med, Chengdu, Peoples R China.
   [Ren, Junyi] Univ Elect Sci & Technol China, Sch Med, Chengdu, Peoples R China.
   [Deng, Gang; Nasser, Moussa Ide] Southern Med Univ, Guangdong Prov Peoples Hosp, Guangdong Cardiovasc Inst, Guangdong Acad Med Sci,Dept Cardiac Surg, Guangzhou, Guangdong, Peoples R China.
C3 University of Electronic Science & Technology of China; Sichuan
   Provincial People's Hospital; Chinese Academy of Sciences; University of
   Electronic Science & Technology of China; Sichuan Provincial People's
   Hospital; Chengdu Medical College; University of Electronic Science &
   Technology of China; Southern Medical University - China; Guangdong
   Academy of Medical Sciences & Guangdong General Hospital
RP Li, GS (corresponding author), Univ Elect Sci & Technol, Sichuan Prov Peoples Hosp, Sichuan Clin Res Ctr Kidney Dis, Dept Nephrol, Chengdu, Peoples R China.; Li, GS (corresponding author), Chinese Acad Sci, Sichuan Translat Med Res Hosp, Chengdu, Peoples R China.; Nasser, MI (corresponding author), Southern Med Univ, Guangdong Prov Peoples Hosp, Guangdong Cardiovasc Inst, Guangdong Acad Med Sci,Dept Cardiac Surg, Guangzhou, Guangdong, Peoples R China.
EM guisenli@163.com; moussa@gdph.org.cn
RI Xu, Xingli/ABF-1974-2021; Nasser, Moussa/AAI-4630-2020; Ren,
   Junyi/NGQ-7091-2025; Li, Guisen/AAS-9461-2021; Deng, Gang/JVF-0233-2024
FU Key R&D plan of Sichuan Province; Project of 2020 High-level Overseas
   Chinese Talent Returning Funding; Overseas Famous Teacher Project of
   Guangdong Provincial Department of Science and Technology
   [2020A1414010311]
FX The work was supported by the foundation of Key R&D plan of Sichuan
   Province (2019YFS0538); The Project of 2020 High-level Overseas Chinese
   Talent Returning Funding; Overseas Famous Teacher Project of Guangdong
   Provincial Department of Science and Technology (2020A1414010311).
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NR 118
TC 10
Z9 11
U1 0
U2 5
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0785-3890
EI 1365-2060
J9 ANN MED
JI Ann. Med.
PD DEC 12
PY 2023
VL 55
IS 2
AR 2284890
DI 10.1080/07853890.2023.2284890
PG 15
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA GJ4Q2
UT WOS:001152292300001
PM 38039549
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Dallagi, Y
   Rahali, D
   Perrotte, M
   Dkhili, H
   Korsan, A
   El May, MV
   El Fazaa, S
   Ramassamy, C
   El Golli, N
AF Dallagi, Yosra
   Rahali, Dalila
   Perrotte, Morgane
   Dkhili, Houssem
   Korsan, Asma
   El May, Michele Veronique
   El Fazaa, Saloua
   Ramassamy, Charles
   El Golli, Narges
TI Date seeds alleviate behavioural and neuronal complications of metabolic
   syndrome in rats
SO ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
LA English
DT Article
DE Metabolic syndrome; date seeds; spatial memory; learning; hippocampus;
   oxidative stress
ID HIGH-FAT DIET; MORRIS WATER MAZE; ALZHEIMERS-DISEASE; PROTOCATECHUIC
   ACID; COGNITIVE DECLINE; OXIDATIVE STRESS; SPATIAL MEMORY; PROTEIN;
   HIPPOCAMPUS; BETA
AB Unhealthy dietary habits can play a crucial role in metabolic damages, promoting alteration of neural functions through the lifespan. Recently, dietary change has been perceived as the first line intervention in prevention and/or treatment of metabolic damages and related diseases. In this context, our study was designed to assess the eventual therapeutic effect of date seeds administration on memory and learning and on neuronal markers in a rat Metabolic Syndrome model. For this purpose, 32 adult male Wistar rats were fed with standard diet or high-fat high-sugar diet during ten weeks. After this, 16 rats were sacrified and the remaining rats received an oral administration of 300 mg of date seeds/kg of body weight during four supplementary weeks. Before sacrifice, we evaluate cognitive performances by the Barnes maze test. Afterwards, neuronal, astrocytic, microtubular and oxidative markers were investigated by immunoblotting methods. In Metabolic syndrome rats, results showed impairment of spatial memory and histological alterations. We identified neuronal damages in hippocampus, marked by a decrease of NeuN and an increase of GFAP and pTau396. Finally, we recorded an increase in protein oxidation and lipid peroxidation, respectively identified by an up-regulation of protein carbonyls and 4-HNe. Interestingly, date seeds administration improved these behavioural, histological, neuronal and oxidative damages highlighting the neuroprotective effect of this natural compound. Liquid Chromatography-Mass Spectrometry (LC-MS) identified, in date seeds, protocatechuic acid, caffeoylshikimic acid and vanillic acid, that could potentially prevent the progression of neurodegenerative diseases, acting through their antioxidant properties.
C1 [Dallagi, Yosra; Rahali, Dalila; Dkhili, Houssem; El Fazaa, Saloua; El Golli, Narges] Univ Tunis El Manar, Fac Sci Tunis, Lab Neurophysiol Cellular Physiopathol & Biomol V, Tunis, Tunisia.
   [Perrotte, Morgane; Ramassamy, Charles] INRS Inst Armand Frappier, Boul Prairies, Laval, PQ, Canada.
   [Korsan, Asma] Univ Tunis El Manar, Fac Sci, Dept Biol, Lab Microorganisms & Act Biomol, Tunis, Tunisia.
   [El May, Michele Veronique] Univ Tunis, Fac Med Tunis, Lab Histol, Tunis, Tunisia.
   [Ramassamy, Charles] Laval Univ, Inst Nutr & Funct Food INAF, Quebec City, PQ, Canada.
C3 Universite de Tunis-El-Manar; Faculte des Sciences de Tunis (FST);
   University of Quebec; Institut national de la recherche scientifique
   (INRS); Universite de Tunis-El-Manar; Faculte des Sciences de Tunis
   (FST); Universite de Tunis-El-Manar; Faculte de Medecine de Tunis (FMT);
   Universite de Tunis; Laval University
RP Dallagi, Y; El Golli, N (corresponding author), Univ Tunis El Manar, Fac Sci Tunis, Lab Neurophysiol Cellular Physiopathol & Biomol V, Tunis, Tunisia.
EM yosradallagi@live.com; nelgolli@yahoo.fr
RI Ramassamy, Charles/LZH-2169-2025
OI Ramassamy, Charles/0000-0002-3252-5878
FU FQRNT Canada
FX The present work was partially supported by a grant provided by FQRNT
   Canada.
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NR 70
TC 1
Z9 1
U1 0
U2 8
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1381-3455
EI 1744-4160
J9 ARCH PHYSIOL BIOCHEM
JI Arch. Physiol. Biochem.
PD MAY 4
PY 2023
VL 129
IS 3
BP 582
EP 596
DI 10.1080/13813455.2020.1849311
EA DEC 2020
PG 15
WC Biochemistry & Molecular Biology; Biophysics; Endocrinology &
   Metabolism; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Endocrinology &
   Metabolism; Physiology
GA F8AL2
UT WOS:000597013200001
PM 33290103
DA 2025-06-11
ER

PT J
AU Nannipieri, M
   Gonzales, C
   Baldi, S
   Posadas, R
   Williams, K
   Haffner, SM
   Stern, MP
   Ferrannini, E
AF Nannipieri, M
   Gonzales, C
   Baldi, S
   Posadas, R
   Williams, K
   Haffner, SM
   Stern, MP
   Ferrannini, E
TI Liver enzymes, the metabolic syndrome, and incident diabetes: The Mexico
   City Diabetes Study
SO DIABETES CARE
LA English
DT Article
ID GAMMA-GLUTAMYL-TRANSFERASE; NONALCOHOLIC STEATOHEPATITIS;
   INSULIN-RESISTANCE; FATTY LIVER; FOLLOW-UP; ALCOHOL-CONSUMPTION; RISK;
   DISEASE; OBESITY; MEN
AB OBJECTIVE - To test the hypothesis that enzymes conventionally associated with liver dysfunction (aspartate aminotransferase, alanine aminotranlsferase, gamma-glutamyltransferase [GGTI, and alkaline phosphatase) may predict diabetes.
   RESEARCH DESIGN AND METHODS - From a population-based diabetes survey, we selected 1,441 men and women in whom serum enzyme levels were <= 3 SDs of the mean population value, alcohol intake was < 250 g/week, and hepatitis B and C virus testing was negative. At follow-up (7 years), 94 subjects developed diabetes and 93 impaired glucose tolerance (IGT).
   RESULTS - At baseline, all four enzymes were related to most of the features of the metabolic syndrome. After controlling for sex, age, adiposity/fat distribution, alcohol intake, serum lipids, and blood pressure, higher alanine aminotransferase and GGT values were significantly (P < 0.01) associated with both IGT and diabetes, whereas alkaline phosphatase was associated with diabetes only (P = 0.0004) and aspartate aminotransferase with IGT only (P = 0.0001). Raised GIST alone was associated with all the features of the metabolic syndrome. Raised GGT was a significant predictor of either IGT or diabetes (odds ratio 1.62 [95% CI 1.08-2.421 top quartile vs. lower quartiles, P < 0.02) after controlling for sex, age, adiposity/fat distribution, alcohol consumption, fasting plasma insulin and proinsulin levels, and 2-h postglucose plasma glucose concentrations.
   CONCLUSIONS - Although mild elevations in liver enzymes are associated with features of the metabolic syndrome, only raised GIST is an independent predictor of deterioration of glucose tolerance to IGT or diabetes. As GGT signals oxidative stress, the association With diabetes may reflect both hepatic steatosis and enhanced oxidative stress.
C1 Univ Pisa, Sch Med, Dept Internal Med, Metab Unit, I-56126 Pisa, Italy.
   Univ Pisa, Sch Med, CNR, Inst Clin Physiol, I-56126 Pisa, Italy.
   Mexican Social Secur Inst, Specialty Hosp Natl Med Ctr, Endocrinol & Metab Serv, Mexico City, DF, Mexico.
   Mexican Social Secur Inst, Amer British Cowdray Hosp, Mexico City, DF, Mexico.
   Univ Texas, Hlth Sci Ctr, Div Clin Epidemiol, San Antonio, TX 78285 USA.
C3 University of Pisa; University of Pisa; Consiglio Nazionale delle
   Ricerche (CNR); Istituto di Fisiologia Clinica (IFC-CNR); Instituto
   Mexicano del Seguro Social; Instituto Mexicano del Seguro Social;
   University of Texas System; University of Texas Health Science Center at
   San Antonio
RP Univ Pisa, Sch Med, Dept Internal Med, Metab Unit, I-56126 Pisa, Italy.
EM ferranni@ifc.cnr.it
RI Nannipieri, Monica/AAA-1464-2019; Ferrannini, Ele/B-8198-2013
OI Nannipieri, Monica/0000-0003-1346-2813
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NR 36
TC 251
Z9 293
U1 0
U2 18
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0149-5992
EI 1935-5548
J9 DIABETES CARE
JI Diabetes Care
PD JUL
PY 2005
VL 28
IS 7
BP 1757
EP 1762
DI 10.2337/diacare.28.7.1757
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 940SG
UT WOS:000230163800033
PM 15983331
OA Bronze
DA 2025-06-11
ER

PT J
AU Sadana, S
   Spees, CK
   Ramaswamy, B
   Taylor, CA
AF Sadana, Susmita
   Spees, Colleen K.
   Ramaswamy, Bhuvaneswari
   Taylor, Christopher A.
TI Cultural Perceptions of Health in Asian Indian Adults
SO JOURNAL OF NUTRITION EDUCATION AND BEHAVIOR
LA English
DT Article
DE Asian Indian; qualitative; health perceptions; acculturation; mental
   health
ID CORONARY-HEART-DISEASE; PHYSICAL-ACTIVITY; SOUTH ASIANS;
   CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; ATHEROSCLEROSIS;
   CLASSIFICATION; STRATEGIES; PAKISTANI; DIAGNOSIS
AB Objective: To gain an understanding of the cultural perceptions of health among Asian Indian adults in an urban setting. Design: Qualitative semistructured interviews. Setting: Midwest urban community Participants: Asian Indian adults (n = 20) aged >= 25 years, who self-identified as 100% Asian Indian descent. Phenomenon of Interest: Individual interviews were conducted by a trained interviewer to assess cultural perceptions of health. Analysis: Transcript analysis was performed by 2 independent coders using verbatim transcripts. Content analysis was used to identify themes using a grounded theory approach. Results: The salient themes that emerged were a cultural definition of health, acculturation, mental health, and health information. Participants believed good health was associated with the ability to perform daily activities, regular exercise, and eating well. There was a lack of awareness of Asian Indian-specific body mass index categories and that overweight and obesity were an important risk factor for chronic diseases. Conclusion and Implications: These data provide a context for health promotion efforts and underscore a gap in awareness of risk factors risk for chronic diseases among the Asian Indian community. Culturally specific interventions targeted at the Asian Indian population, considering their worldview and perceptions of will address this health concern.
C1 [Sadana, Susmita] Ohio State Univ, Sch Hlth & Rehabil Sci, Columbus, OH USA.
   [Spees, Colleen K.] Ohio State Univ, Coll Med, Sch Hlth & Rehabil Sci, Div Med Dietet, Columbus, OH USA.
   [Ramaswamy, Bhuvaneswari; Taylor, Christopher A.] Ohio State Univ, Wexner Med Ctr, Dept Med Oncol, Columbus, OH USA.
C3 University System of Ohio; Ohio State University; University System of
   Ohio; Ohio State University; University System of Ohio; Ohio State
   University
RP Taylor, CA (corresponding author), Ohio State Univ, Med Dietet Div, Wexner Med Ctr, 306A Atwell Hall,453 W 10th Ave, Columbus, OH 43210 USA.
EM taylor.1043@osu.edu
RI Ramaswamy, Bhuvaneswari/E-3919-2011
OI Spees, Colleen/0000-0001-6293-2899
FU Office of the Director of Research in The School of Health and
   Rehabilitation Sciences
FX This work was supported by an unre-stricted grant from The Office of the
   Director of Research in The School of Health and Rehabilitation
   Sciences.
CR Ali SH, 2020, PREV MED REP, V20, DOI 10.1016/j.pmedr.2020.101182
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NR 45
TC 0
Z9 0
U1 0
U2 0
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1499-4046
EI 1878-2620
J9 J NUTR EDUC BEHAV
JI J. Nutr. Educ. Behav.
PD NOV
PY 2024
VL 56
IS 11
BP 775
EP 782
DI 10.1016/j.jneb.2024.07.005
EA NOV 2024
PG 8
WC Education, Scientific Disciplines; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Education & Educational Research; Nutrition & Dietetics
GA N2F4N
UT WOS:001362554300001
PM 39186023
OA hybrid
DA 2025-06-11
ER

PT J
AU Christofoletti, CR
   Fernandes, ACF
   Gandra, RLP
   Martins, IM
   Gambero, A
   Macedo, GA
   Macedo, JA
AF Christofoletti, Camila Rubia
   Fernandes, Annayara C. F.
   Gandra, Renata L. P.
   Martins, Isabela M.
   Gambero, Alessandra
   Macedo, Gabriela A.
   Macedo, Juliana A.
TI Wine residues extracts modulating in vitro metabolic syndrome
SO FOOD BIOSCIENCE
LA English
DT Article
DE Phenolic compounds; Anti-inflammatory; Tannase; Grape pomace;
   Biotransformation
ID NF-KAPPA-B; OXIDATIVE STRESS; ANTIOXIDANT ACTIVITY; CACO-2 CELLS; GRAPE
   POMACE; MACROPHAGES; OBESITY; INFLAMMATION; POLYPHENOLS; EXPRESSION
AB Metabolic syndrome is considered a worldwide epidemic health problem. The manifestations include obesity, dyslipidemias, elevation of arterial blood pressure, and insulin resistance. The wine waste is composed mainly of skin, seed and grape pomace, and is a source of phenolic compounds. Previous studies have demonstrated that grape phenolic compounds have antioxidants and anti-inflammatory properties, acting directly in the pathogenic process of several diseases. In order to improve the bioavailability and bioactivity of these compounds, enzymatic biotransformation reactions were developed.The aimed of this work was to evaluate whether phenolic extracts produced with wine waste by biotrans-formation with Tannase (tannin acyl hydrolase), were able to attenuate the metabolic syndrome manifestations like oxidative stress and reduce the inflammatory parameters in vitro assays.Four different extracts were produced and the non-citotoxic concentrations of samples used (100, 200 and 500 mu g/mL) were determined by MTT assay. The inflammatory response was induced in macrophages (RAW 264.7) culture using LPS (Lipopolysaccharide). The biotransformed extracts were able to reduce the TNF-alpha cell culture supernatant concentration by about 44%; and the IL-6 secretion was reduced by 82%. All the extracts demon-strate efficacy in reduction of intracellular reactive oxygen species (ROS) production and the same was observed for NO (nitric oxide) concentration in the cell culture supernatant after the administration of extracts. These results indicated the strong potential of employing phenolic wine waste extracts on the modulation of metabolic syndrome parameters, use that also brings environmental and socioeconomic advantages, since it brings an alternative for the use of residues.
C1 [Christofoletti, Camila Rubia; Fernandes, Annayara C. F.; Gandra, Renata L. P.; Martins, Isabela M.; Macedo, Gabriela A.; Macedo, Juliana A.] Univ Campinas UNICAMP, Sch Food Engn, Food & Nutr Dept, BR-13083862 Campinas, SP, Brazil.
   [Gambero, Alessandra] Pontificia Univ Catolica Campinas, Ctr Ciencias Vida, BR-13034685 Campinas, SP, Brazil.
C3 Universidade Estadual de Campinas; Pontificia Universidade Catolica de
   Campinas
RP Christofoletti, CR (corresponding author), 1017 Eight St,House 24, BR-13501090 Rio Claro, SP, Brazil.
EM camila.rubia03@gmail.com
RI Martins, Isabela/K-9135-2016; Gambero, Alessandra/G-5792-2013; Macedo,
   Juliana/H-1961-2012
OI Rubia Christofoletti, Camila/0000-0002-8525-9059; Macedo,
   Juliana/0000-0001-7504-8111
FU CNPq (Brazil) [168936/2018-6]
FX The authors greatfully acknowledge CNPq (Brazil, 168936/2018-6) , for
   financial support.
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NR 46
TC 4
Z9 4
U1 0
U2 10
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2212-4292
EI 2212-4306
J9 FOOD BIOSCI
JI Food Biosci.
PD DEC
PY 2022
VL 50
AR 101957
DI 10.1016/j.fbio.2022.101957
EA SEP 2022
PN A
PG 7
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA 5F7BR
UT WOS:000866467400005
DA 2025-06-11
ER

PT J
AU Ogawa, S
   Hori, H
   Niwa, M
   Itoh, M
   Lin, MM
   Yoshida, F
   Ino, K
   Kawanishi, H
   Narita, M
   Nakano, W
   Imai, R
   Matsui, M
   Kamo, T
   Kunugi, H
   Hattori, K
   Kim, Y
AF Ogawa, Shintaro
   Hori, Hiroaki
   Niwa, Madoka
   Itoh, Mariko
   Lin, Mingming
   Yoshida, Fuyuko
   Ino, Keiko
   Kawanishi, Hitomi
   Narita, Megumi
   Nakano, Wakako
   Imai, Risa
   Matsui, Mie
   Kamo, Toshiko
   Kunugi, Hiroshi
   Hattori, Kotaro
   Kim, Yoshiharu
TI Serum lipid and plasma fatty acid profiles in PTSD patients and healthy
   individuals: Associations with symptoms, cognitive function, and
   inflammatory markers
SO PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
LA English
DT Article
DE PTSD; Lipid-related molecules; Fatty acids; Cognitive function;
   Inflammation; Latent profile analysis; Precision treatment
ID POSTTRAUMATIC-STRESS-DISORDER; MAJOR DEPRESSIVE DISORDER; METABOLIC
   SYNDROME; BINDING PROTEIN; RISK-FACTORS; CHOLESTEROL; TRAUMA;
   VALIDATION; EXPRESSION; MACROPHAGES
AB Increasing evidence suggests that posttraumatic stress disorder (PTSD), a serious mental health condition, is associated with physical health problems. Lipid-related molecules are crucial for central nervous system functions associated with PTSD symptoms; however, case-control studies exploring the relationship between PTSD and lipid-related molecules are scarce. We examined 68 civilian PTSD patients and 97 healthy controls, evaluating PTSD symptoms, childhood maltreatment history, suicidality, and cognitive functions. Cholesterol, triglycerides, and inflammation-related marker levels were analyzed in serum, while fatty acid levels were measured in plasma. Compared to controls, patients exhibited significantly lower high-density lipoprotein cholesterol and n-6 linoleic acid levels, alongside higher saturated palmitic acid levels and the triene-to-tetraene (T/T) ratio. PTSD symptoms, particularly hyperarousal, were significantly positively correlated with n-6 gamma-linolenic, n-6 dihomo-gamma-linolenic, and n-9 mead acid levels, and the T/T ratio. Cognitive functions were significantly positively correlated with n-3 docosahexaenoic acid and total n-3 fatty acid levels, and negatively correlated with saturated lauric, palmitic, and total saturated fatty acid levels. Suicidality was significantly positively correlated with dihomo-gamma-linolenic acid, mead acid levels, and the T/T ratio, and negatively correlated
C1 [Ogawa, Shintaro; Hori, Hiroaki; Niwa, Madoka; Itoh, Mariko; Lin, Mingming; Yoshida, Fuyuko; Ino, Keiko; Kawanishi, Hitomi; Narita, Megumi; Nakano, Wakako; Imai, Risa; Kamo, Toshiko; Kim, Yoshiharu] Natl Ctr Neurol & Psychiat, Natl Inst Mental Hlth, Dept Behav Med, 4-1-1 Ogawa Higashi, Kodaira, Tokyo 1878553, Japan.
   [Ogawa, Shintaro; Hori, Hiroaki; Yoshida, Fuyuko; Kunugi, Hiroshi; Hattori, Kotaro] Natl Ctr Neurol & Psychiat, Natl Inst Neurosci, Dept Mental Disorder Res, Kodaira, Tokyo, Japan.
   [Itoh, Mariko] Hokkaido Univ, Ctr Environm & Hlth Sci, Sapporo, Hokkaido, Japan.
   [Lin, Mingming] RIKEN Ctr Brain Sci, Lab Imaginat & Execut Funct, 2-1 Hirosawa, Wako, Saitama 3510198, Japan.
   [Ino, Keiko; Imai, Risa] Nagoya City Univ, Grad Sch Med Sci, Grad Sch Med Sci, Nagoya, Aichi, Japan.
   [Kawanishi, Hitomi] Natl Ctr Neurol & Psychiat, Integrat Brain Imaging Ctr, Integrat Brain Imaging Ctr, Kodaira, Tokyo, Japan.
   [Kawanishi, Hitomi] Tohoku Univ, Grad Sch Med, Grad Sch Med, Sendai, Miyagi, Japan.
   [Imai, Risa] Risa Irinaka Mental Clin, Nagoya, Aichi, Japan.
   [Matsui, Mie] Kanazawa Univ, Inst Liberal Arts & Sci, Kanazawa, Ishikawa 9201192, Japan.
   [Kamo, Toshiko] Wakamatsu Cho Mental & Skin Clin, Tokyo, Japan.
   [Kunugi, Hiroshi] Teikyo Univ, Dept Psychiat, Sch Med, Tokyo, Tokyo, Japan.
   [Hattori, Kotaro] Natl Ctr Neurol & Psychiat, Med Genome Ctr, Dept Bioresources, Kodaira, Tokyo, Japan.
C3 National Center for Neurology & Psychiatry - Japan; National Center for
   Neurology & Psychiatry - Japan; Hokkaido University; RIKEN; Nagoya City
   University; National Center for Neurology & Psychiatry - Japan; Tohoku
   University; Kanazawa University; Teikyo University; National Center for
   Neurology & Psychiatry - Japan
RP Ogawa, S; Hori, H (corresponding author), Natl Ctr Neurol & Psychiat, Natl Inst Mental Hlth, Dept Behav Med, 4-1-1 Ogawa Higashi, Kodaira, Tokyo 1878553, Japan.
EM sogawa@ncnp.go.jp; hori@ncnp.go.jp
RI Kunugi, Hiroshi/ABC-5260-2021; Hori, Hiroaki/AFL-5633-2022
FU Multilayered Stress Diseases, TMDU [JPMXP1323015483]; Japan Society for
   the Promotion of Science (JSPS) [23K07002, 22H00469, 16K13501,
   26590172]; Innovative Research Program on Suicide Counter-measures by
   the Ministry of Health, Labour and Welfare; Japan Support Center for
   Suicide Countermeasures (JSSC); Intramural Research Grant for
   Neurological and Psychiatric Disorders of NCNP
FX This work was supported by Multilayered Stress Diseases
   (JPMXP1323015483) , TMDU; Japan Society for the Promotion of Science
   (JSPS) [23K07002 to HH, 22H00469 to YK, 16K13501 to MI, 26590172 to ML]
   ; Innovative Research Program on Suicide Counter-measures by the
   Ministry of Health, Labour and Welfare and the Japan Support Center for
   Suicide Countermeasures (JSSC) [3-2 and 2-1 to YK] ; and Intramural
   Research Grant for Neurological and Psychiatric Disorders of NCNP [2-2
   to YK and 5-2 to HH] .
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NR 82
TC 0
Z9 0
U1 2
U2 2
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0278-5846
EI 1878-4216
J9 PROG NEURO-PSYCHOPH
JI Prog. Neuro-Psychopharmacol. Biol. Psychiatry
PD APR 2
PY 2025
VL 138
AR 111298
DI 10.1016/j.pnpbp.2025.111298
EA MAR 2025
PG 14
WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA 0BB5T
UT WOS:001443131900001
PM 39988258
DA 2025-06-11
ER

PT J
AU Bu, J
   Ding, RL
   Zhou, LJ
   Chen, XM
   Shen, ER
AF Bu, Jin
   Ding, Ruilian
   Zhou, Liangjia
   Chen, Xiangming
   Shen, Erxia
TI Epidemiology of Psoriasis and Comorbid Diseases: A Narrative Review
SO FRONTIERS IN IMMUNOLOGY
LA English
DT Review
DE psoriasis disease; comorbid disease; epidemiology; autoimmune chronic
   diseases; prevalence
ID INFLAMMATORY-BOWEL-DISEASE; QUALITY-OF-LIFE; METABOLIC SYNDROME;
   RHEUMATOID-ARTHRITIS; ATOPIC-DERMATITIS; LIVER FIBROSIS; INCREASED RISK;
   PREVALENCE; ASSOCIATION; INFECTION
AB Psoriasis is a chronic autoimmune inflammatory disease that remains active for a long period, even for life in most patients. The impact of psoriasis on health is not only limited to the skin, but also influences multiple systems of the body, even mental health. With the increasing of literature on the association between psoriasis and extracutaneous systems, a better understanding of psoriasis as an autoimmune disease with systemic inflammation is created. Except for cardiometabolic diseases, gastrointestinal diseases, chronic kidney diseases, malignancy, and infections that have received much attention, the association between psoriasis and more systemic diseases, including the skin system, reproductive system, and oral and ocular systems has also been revealed, and mental health diseases draw more attention not just because of the negative mental and mood influence caused by skin lesions, but a common immune-inflammatory mechanism identified of the two systemic diseases. This review summarizes the epidemiological evidence supporting the association between psoriasis and important and/or newly reported systemic diseases in the past 5 years, and may help to comprehensively recognize the comorbidity burden related to psoriasis, further to improve the management of people with psoriasis.
C1 [Bu, Jin; Ding, Ruilian; Zhou, Liangjia] Chinese Acad Med Sci & Peking Union Med Coll, Hosp Skin Dis, Inst Dermatol, Nanjing, Peoples R China.
   [Chen, Xiangming; Shen, Erxia] Guangzhou Med Univ, Affiliated Hosp 2, Sino French Hoffmann Inst, Sch Basic Med, Guangzhou, Peoples R China.
   [Shen, Erxia] Guangzhou Med Univ, Affiliated Hosp 1, State Key Lab Resp Dis, Guangzhou, Peoples R China.
C3 Chinese Academy of Medical Sciences - Peking Union Medical College;
   Institute of Dermatology - CAMS; Peking Union Medical College; Guangzhou
   Medical University; Guangzhou Medical University; State Key Laboratory
   of Respiratory Disease
RP Shen, ER (corresponding author), Guangzhou Med Univ, Affiliated Hosp 2, Sino French Hoffmann Inst, Sch Basic Med, Guangzhou, Peoples R China.; Shen, ER (corresponding author), Guangzhou Med Univ, Affiliated Hosp 1, State Key Lab Resp Dis, Guangzhou, Peoples R China.
EM erxia_shen@gzhmu.edu.cn
RI Bu, Jin/ACG-7610-2022
OI Bu, Jin/0000-0001-8555-0922
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NR 218
TC 124
Z9 128
U1 10
U2 47
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-3224
J9 FRONT IMMUNOL
JI Front. Immunol.
PD JUN 10
PY 2022
VL 13
AR 880201
DI 10.3389/fimmu.2022.880201
PG 19
WC Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology
GA 2J5DD
UT WOS:000815676500001
PM 35757712
OA gold, Green Published
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Bondia-Pons, I
   Martinez, JA
   de la Iglesia, R
   Lopez-Legarrea, P
   Poutanen, K
   Hanhineva, K
   Zulet, MD
AF Bondia-Pons, Isabel
   Alfredo Martinez, Jose
   de la Iglesia, Rocio
   Lopez-Legarrea, Patricia
   Poutanen, Kaisa
   Hanhineva, Kati
   de los Angeles Zulet, Maria
TI Effects of short- and long-term Mediterranean-based dietary treatment on
   plasma LC-QTOF/MS metabolic profiling of subjects with metabolic
   syndrome features: The Metabolic Syndrome Reduction in Navarra (RESMENA)
   randomized controlled trial
SO MOLECULAR NUTRITION & FOOD RESEARCH
LA English
DT Article
DE Dependency networks; LC-QTOF/MS; Mediterranean diet; Metabolomics;
   Metabolic syndrome
ID FATTY-ACID; WEIGHT-LOSS; OXIDATIVE STRESS; PALMITIC ACID; COMPONENTS;
   STRATEGY; IMPROVES; PATTERN; LEGUMES; HEALTH
AB Scope: Adherence to the Mediterranean diet has been associated with a reduced risk of metabolic syndrome (MetS). Metabolomics approach may contribute to identify beneficial associations of metabolic changes affected by Mediterranean diet-based interventions with inflammatory and oxidative-stress markers related to the etiology and development of the MetS.
   Methods and results: Liquid chromatography coupled to quadrupole-time of flight-MS metabolic profiling was applied to plasma from a 6-month randomized intervention with two sequential periods, a 2-month nutritional-learning intervention period, and a 4-month self-control period, with two energy-restricted diets; the RESMENA diet (based on the Mediterranean dietary pattern) and the Control diet (based on the American Heart Association guidelines), in 72 subjects with a high BMI and at least two features of MetS. The major contributing biomarkers of each sequential period were lipids, mainly phospholipids and lysophospholipids. Dependency network analysis showed a different pattern of associations between metabolic changes and clinical variables after 2 and 6 month of intervention, with a highly interconnected network during the nutritional-learning intervention period of the study.
   Conclusion: The 2-month RESMENA diet produced significant changes in the plasma metabolic profile of subjects with MetS features. However, at the end of the 6-month study, most of the associations between metabolic and clinical variables disappeared; suggesting that adherence to healthy dietary habits had declined during the self-control period.
C1 [Bondia-Pons, Isabel; Poutanen, Kaisa] VTT Tech Res Ctr Finland, Espoo, Finland.
   [Bondia-Pons, Isabel; Alfredo Martinez, Jose; de la Iglesia, Rocio; Lopez-Legarrea, Patricia; de los Angeles Zulet, Maria] Univ Navarra, Dept Nutr Food Sci & Physiol, Pamplona 31008, Spain.
   [Alfredo Martinez, Jose; de los Angeles Zulet, Maria] Inst Salud Carlos III, CIBERobn, Madrid, Spain.
   [Lopez-Legarrea, Patricia] Univ Autonoma Chile, Fac Ciencias Salud, Santiago, Chile.
   [Poutanen, Kaisa; Hanhineva, Kati] Univ Eastern Finland, Clin Nutr, Inst Publ Hlth & Clin Nutr, Kuopio, Finland.
C3 VTT Technical Research Center Finland; University of Navarra; Instituto
   de Salud Carlos III; CIBER - Centro de Investigacion Biomedica en Red;
   CIBEROBN; Universidad Autonoma de Chile; University of Eastern Finland
RP Zulet, MD (corresponding author), Univ Navarra, Dept Nutr Food Sci & Physiol, C Irunlarrea 1, Pamplona 31008, Spain.
EM mazulet@unav.es
RI de la Iglesia, Rocio/ABC-6189-2020; Hanhineva, Kati/AAH-1699-2019;
   Zulet, M. Angeles/H-1317-2017; Martinez Hernandez, J Alfredo/K-8709-2014
OI Hanhineva, Kati/0000-0001-6834-7375; de la Iglesia,
   Rocio/0000-0002-7472-3565; Zulet, M. Angeles/0000-0002-3926-0892;
   Martinez Hernandez, J Alfredo/0000-0001-5218-6941
FU Health Department of the Government of Navarra [48/2009]; Linea Especial
   about Nutrition, Obesity and Health (University of Navarra) [LE/97];
   Government of Navarra
FX This work was supported by the Health Department of the Government of
   Navarra (48/2009) and by Linea Especial about Nutrition, Obesity and
   Health (University of Navarra LE/97). I.B.-P. is grateful to the Carlos
   III Health Institute of the Spanish Ministry of Health for her Sara
   Borrell postdoctoral contract. R.d.I. and P.L.L. are grateful to the
   Government of Navarra for their PhD fellowships. We acknowledge the
   volunteers for their participation in the study, Dr. Santiago
   Navas-Carretero for volunteers' recruitment, Dr. Itziar Abete for design
   of the diets, the physician Blanca E. Martinez de Morentin, and the
   nurse Salome Perez for excellent participants' medical follow-up during
   the intervention, Dr. Pekka Keski-Rahkonen for running the LCQTOF/MS
   samples, and Veronica Ciaurriz for laboratory technical assistance.
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NR 53
TC 53
Z9 56
U1 2
U2 27
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1613-4125
EI 1613-4133
J9 MOL NUTR FOOD RES
JI Mol. Nutr. Food Res.
PD APR
PY 2015
VL 59
IS 4
BP 711
EP 728
DI 10.1002/mnfr.201400309
PG 18
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA CF8CK
UT WOS:000352782800010
PM 25641909
DA 2025-06-11
ER

PT J
AU Valle, E
   Storace, D
   Sanguineti, R
   Carter, R
   Odetti, P
   Geor, R
   Bergero, D
AF Valle, E.
   Storace, D.
   Sanguineti, R.
   Carter, R.
   Odetti, P.
   Geor, R.
   Bergero, D.
TI Association of the glycoxidative stress marker pentosidine with equine
   laminitis
SO VETERINARY JOURNAL
LA English
DT Article
DE Ponies; Laminitis; Pentosidine; Advanced glycoxidation end-products;
   Equine metabolic syndrome
ID GLYCATION END-PRODUCTS; INSULIN-RESISTANCE; DIABETES-MELLITUS; METABOLIC
   PREDISPOSITIONS; OXIDATIVE STRESS; RISK-FACTORS; HORSES; PASTURE;
   INFLAMMATION; PLASMA
AB Ponies suffering from recurrent episodes of laminitis when grazed at pasture (pasture-associated laminitis) exhibit phenotypes similar to those associated with human metabolic syndrome. In humans, evidence suggests that the obesity-related morbidities associated with metabolic syndrome, including diabetes and cardiovascular disease, are caused by an increase in the production of advanced glycoxidation end-products (AGEs). These end-products have been recognised as putative pro-inflammatory mediators and are considered a 'risk factor' for human health. However, the evaluation of AGEs in laminitic ponies has not been explored.
   The aim of this study was to compare plasma concentrations of the AGE pentosidine (PENT) in ponies presenting with clinical features of equine metabolic syndrome (EMS) with a history of recent laminitis and/or showing signs of laminitis at the time of sampling (LP) with those with no prior history of clinical laminitis (NL). Age, body condition score (BCS) and bodyweight were recorded and blood samples Collected for the measurement of plasma concentrations of PENT, glucose, insulin, triglycerides (TG), non-esterified fatty acids (NEFA) and cortisol. Insulin sensitivity was assessed by the reciprocal of the square root of insulin (RISQI) and the insulin:glucose ratio. Plasma PENT concentrations were twofold higher (P < 0.005) in LP than in NL ponies. Significant (P < 0.05) correlations were also evident between PENT and insulin, RISQI, TG and age. These preliminary findings are consistent with the hypothesis that glycoxidation in laminitis is associated with EMS. (C) 2012 Elsevier Ltd. All rights reserved.
C1 [Valle, E.; Bergero, D.] Univ Turin, Fac Vet Med, Dept Anim Prod Epidemiol & Ecol, I-10124 Turin, Italy.
   [Storace, D.; Sanguineti, R.; Odetti, P.] Univ Genoa, Dept Internal Med & Med Special, Div Geriatr, I-16126 Genoa, Italy.
   [Carter, R.; Geor, R.] Virginia Tech, Dept Anim & Poultry Sci, Blacksburg, VA USA.
C3 University of Turin; University of Genoa; Virginia Polytechnic Institute
   & State University
RP Valle, E (corresponding author), Univ Turin, Fac Vet Med, Dept Anim Prod Epidemiol & Ecol, I-10124 Turin, Italy.
EM emanuela.valle@unito.it
RI Geor, Raymond/P-4631-2017; valle, emanuela/AFX-9345-2022; valle,
   emanuela/G-5662-2015
OI Geor, Raymond/0000-0002-6825-6737; valle, emanuela/0000-0002-5519-3554;
   ODETTI, PATRIZIO/0000-0001-9559-7273; Sanguineti,
   Roberta/0000-0002-3130-9372
FU University of Turin
FX This study was supported by grants from the University of Turin (ex 60%
   Grant 2007). The paper is dedicated to Daniela Storace who died suddenly
   in August 2010. Her death is a huge loss for the research community of
   the DIMI.
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NR 49
TC 9
Z9 9
U1 0
U2 21
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1090-0233
EI 1532-2971
J9 VET J
JI Vet. J.
PD JUN
PY 2013
VL 196
IS 3
BP 445
EP 450
DI 10.1016/j.tvjl.2012.10.030
PG 6
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA 182EO
UT WOS:000321724700033
PM 23206662
DA 2025-06-11
ER

PT J
AU Cui, F
   Mi, HC
   Wang, RT
   Du, YT
   Li, F
   Chang, SY
   Su, YC
   Liu, AJ
   Shi, M
AF Cui, Fang
   Mi, Haichao
   Wang, Ruotong
   Du, Yutao
   Li, Fan
   Chang, Shiyang
   Su, Yangchen
   Liu, Aijing
   Shi, Min
TI The effect of chronic intermittent hypobaric hypoxia improving liver
   damage in metabolic syndrome rats through ferritinophagy
SO PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
LA English
DT Article
DE Chronic intermittent hypobaric hypoxia; Metabolic syndrome; NCOA4;
   Ferritinophagy; Ferroptosis
ID OXIDATIVE STRESS; IRON; DEGRADATION; FERROPTOSIS; AUTOPHAGY; MECHANISMS;
   PROTECTS; FRUCTOSE; PATHWAY; DISEASE
AB Studies have confirmed that hepatic iron overload is one of the important factors causing liver damage in the metabolic syndrome (MS). As a special form of autophagy, ferritinophagy is involved in the regulation of iron metabolism. Our previous studies have shown that chronic intermittent hypobaric hypoxia (CIHH) can improve the iron metabolism disorder. The aim of this study was to investigate how CIHH improves liver damage through ferritinophagy in MS rats. Male Sprague-Dawley rats aged 8-10 weeks were randomly divided into four groups: control (CON), CIHH (exposed to hypoxia at a simulated altitude of 5000 m for 28 days, 6 h daily), MS model (induced by a 16-week high-fat diet and 10% fructose water feeding), and MS + CIHH (exposed to CIHH after a 16-week MS inducement) groups. Liver index, liver function, iron content, tissue morphology, oxidative stress, ferritinophagy, ferroptosis, and iron metabolism-related protein expression were measured, and the ferritinophagy flux in the liver was further analyzed. Compared with CON rats, MS rats had an increased liver index, damaged liver tissue and function, increased iron content and iron deposition, disrupted iron metabolism, significantly increased oxidative stress indicators in the liver, significantly upregulated expression of ferroptosis-related proteins, and downregulated expression of nuclear receptor coactivator 4 (NCOA4) and ferritinophagy flux. After CIHH treatment, the degree of liver damage and various abnormal indicators in MS rats were significantly improved. CIHH may improve liver damage by promoting NCOA4-mediated ferritinophagy, reducing iron overload and oxidative stress, and thereby alleviating ferroptosis in MS rats.
C1 [Cui, Fang; Wang, Ruotong; Du, Yutao; Shi, Min] Hebei Med Univ, Hosp 2, Dept Clin Lab, Shijiazhuang 050000, Hebei, Peoples R China.
   [Cui, Fang] Hebei Med Univ, Dept Electron Microscope Lab, Shijiazhuang 050017, Peoples R China.
   [Mi, Haichao] Linyi Peoples Hosp, Dept Clin Lab, Linyi 276003, Peoples R China.
   [Li, Fan] Hebei Med Univ, Dept Pathol, Shijiazhuang 050017, Peoples R China.
   [Chang, Shiyang] Hebei Med Univ, Dept Histol & Embryol, Shijiazhuang 050017, Peoples R China.
   [Su, Yangchen] Hebei Med Univ, Coll Basic Med, Shijiazhuang 050017, Peoples R China.
   [Liu, Aijing] Hebei Med Univ, Hosp 2, Dept Rheumatol & Immunol, Shijiazhuang 050000, Peoples R China.
   [Shi, Min] Hebei Key Lab Lab Med, Shijiazhuang 050017, Peoples R China.
C3 Hebei Medical University; Hebei Medical University; Hebei Medical
   University; Hebei Medical University; Hebei Medical University; Hebei
   Medical University
RP Shi, M (corresponding author), Hebei Med Univ, Hosp 2, Dept Clin Lab, Shijiazhuang 050000, Hebei, Peoples R China.; Shi, M (corresponding author), Hebei Key Lab Lab Med, Shijiazhuang 050017, Peoples R China.
EM sm0706@hb2h.com
OI Shi, Min/0009-0004-8316-447X
FU Hebei Natural Science Foundation [H2020206396]; University Students'
   Innovative Experiment Program [USIP2022103]
FX The authors disclosed receipt of the following financial support for the
   research, authorship, and/or publication of this article: project
   H2020206396 supported by the Hebei Natural Science Foundation and
   USIP2022103 supported by the University Students' Innovative Experiment
   Program
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NR 72
TC 2
Z9 3
U1 3
U2 9
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0031-6768
EI 1432-2013
J9 PFLUG ARCH EUR J PHY
JI Pflugers Arch.
PD NOV
PY 2023
VL 475
IS 11
BP 1251
EP 1263
DI 10.1007/s00424-023-02860-6
EA SEP 2023
PG 13
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA U9QZ5
UT WOS:001071605500001
PM 37747537
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Olgar, Y
   Durak, A
   Degirmenci, S
   Tuncay, E
   Billur, D
   Ozdemir, S
   Turan, B
AF Olgar, Yusuf
   Durak, Aysegul
   Degirmenci, Sinan
   Tuncay, Erkan
   Billur, Deniz
   Ozdemir, Semir
   Turan, Belma
TI Ticagrelor alleviates high-carbohydrate intake induced altered
   electrical activity of ventricular cardiomyocytes by regulating
   sarcoplasmic reticulum-mitochondria miscommunication
SO MOLECULAR AND CELLULAR BIOCHEMISTRY
LA English
DT Article
DE Metabolic syndrome; Arrhythmia; Insulin resistance; Electrical activity;
   Heart dysfunction; Mitochondria; Sarcoplasmic reticulum; Oxidative
   stress
ID ENDOPLASMIC-RETICULUM; ANTIPLATELET THERAPY; PLATELET INHIBITION;
   METABOLIC-SYNDROME; P2Y(12) RECEPTORS; CA2+ TRANSIENTS; INSULIN; HEART;
   DYSFUNCTION; HOMEOSTASIS
AB Metabolic syndrome (MetS) is associated with additional cardiovascular risk in mammalians while there are relationships between hyperglycemia-associated cardiovascular dysfunction and increased platelet P2Y12 receptor activation. Although P2Y12 receptor antagonist ticagrelor (Tica) plays roles in reduction of cardiovascular events, its beneficial mechanism remains poorly understood. Therefore, we aimed to clarify whether Tica can exert a direct protective effect in ventricular cardiomyocytes from high-carbohydrate diet-induced MetS rats, at least, through affecting sarcoplasmic reticulum (SR)-mitochondria (Mit) miscommunication. Tica treatment of MetS rats (150 mg/kg/day for 15 days) significantly reversed the altered parameters of action potentials by reversing sarcolemmal ionic currents carried by voltage-dependent Na+ and K+ channels, and Na+/Ca2+-exchanger in the cells, expressed P2Y12 receptors. The increased basal-cytosolic Ca2+ level and depressed SR Ca2+ load were also reversed in Tica-treated cells, at most, though recoveries in the phosphorylation levels of ryanodine receptors and phospholamban. Moreover, there were marked recoveries in Mit structure and function (including increases in both autophagosomes and fragmentations) together with recoveries in Mit proteins and the factors associated with Ca2+ transfer between SR-Mit. There were further significant recoveries in markers of both ER stress and oxidative stress. Taken into consideration the Tica-induced prevention of ER stress and mitochondrial dysfunction, our data provided an important document on the pleiotropic effects of Tica in the electrical activity of the cardiomyocytes from MetS rats. This protective effect seems through recoveries in SR-Mit miscommunication besides modulation of different sarcolemmal ion-channel activities, independent of P2Y12 receptor antagonism.
C1 [Olgar, Yusuf; Durak, Aysegul; Degirmenci, Sinan; Tuncay, Erkan; Turan, Belma] Ankara Univ, Fac Med, Dept Biophys, Ankara, Turkey.
   [Billur, Deniz] Ankara Univ, Fac Med, Dept Histol & Embryol, Ankara, Turkey.
   [Ozdemir, Semir] Akdeniz Univ, Fac Med, Dept Biophys, Antalya, Turkey.
   [Turan, Belma] Lokman Hekim Univ, Fac Med, Dept Biophys, Ankara, Turkey.
C3 Ankara University; Ankara University; Akdeniz University; Lokman Hekim
   University
RP Turan, B (corresponding author), Ankara Univ, Fac Med, Dept Biophys, Ankara, Turkey.; Ozdemir, S (corresponding author), Akdeniz Univ, Fac Med, Dept Biophys, Antalya, Turkey.; Turan, B (corresponding author), Lokman Hekim Univ, Fac Med, Dept Biophys, Ankara, Turkey.
EM osemir@akdeniz.edu.tr; belma.turan@medicine.ankara.edu.tr
RI Billur, Deniz/N-4933-2018; olğar, yusuf/I-8960-2016; TUNCAY,
   ERKAN/AAG-8065-2020; durak, aysegul/AAA-7647-2022; Değirmenci,
   Sinan/M-7694-2013; ozdemir, semir/ISA-6373-2023; TURAN,
   Belma/AAG-8084-2020; ozdemir, semir/P-8727-2015
OI TURAN, Belma/0000-0003-2583-9294; ozdemir, semir/0000-0002-4807-7344
FU Scientific and Technological Research Council of Turkey [SBAG216S979]
FX This work was supported by Grants (No. SBAG216S979) from The Scientific
   and Technological Research Council of Turkey.
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NR 62
TC 2
Z9 2
U1 1
U2 19
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0300-8177
EI 1573-4919
J9 MOL CELL BIOCHEM
JI Mol. Cell. Biochem.
PD OCT
PY 2021
VL 476
IS 10
BP 3827
EP 3844
DI 10.1007/s11010-021-04205-2
EA JUN 2021
PG 18
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA UF1LI
UT WOS:000659800400003
PM 34114148
DA 2025-06-11
ER

PT J
AU Moodley, A
   Womersley, JS
   Swart, PC
   van den Heuvel, LL
   Malan-Müller, S
   Seedat, S
   Hemmings, SMJ
AF Moodley, Allegra
   Womersley, Jacqueline S.
   Swart, Patricia C.
   van den Heuvel, Leigh L.
   Malan-Muller, Stefanie
   Seedat, Soraya
   Hemmings, Sian M. J.
TI A network analysis investigating the associations between posttraumatic
   stress symptoms, markers of inflammation and metabolic syndrome
SO JOURNAL OF PSYCHIATRIC RESEARCH
LA English
DT Article
DE Trauma exposure; Posttraumatic stress disorder; Pro-inflammatory
   cytokines; Metabolic syndrome; Network analysis
ID C-REACTIVE PROTEIN; IMMUNE-SYSTEM; TNF-ALPHA; DISORDER; PTSD;
   ADIPONECTIN; POPULATION; PREVALENCE; COMPONENTS; IL-6
AB Chronic systemic inflammation has been implicated in trauma exposure, independent of a psychiatric diagnosis, and in posttraumatic stress disorder (PTSD) and its highly comorbid conditions, such as metabolic syndrome (MetS). The present study used network analysis to examine the interacting associations between pro-inflammatory cytokines, posttraumatic stress (PTS) symptoms and symptom clusters, and individual compo-nents of MetS, in a cohort of 312 participants (n = 139 PTSD cases, n = 173 trauma-exposed controls). Pro-inflammatory cytokines were measured in serum samples using immunoturbidimetric and multiplex assays. Three network models were assessed, and the decision on which model to use was guided by network stability estimates and denseness. Weak negative associations were observed between interleukin one beta (IL-1 & beta;) and detachment (D6) and irritability (E1); tumour necrosis factor alpha (TNF & alpha;) and hypervigilance (E3); and C -reactive protein (CRP) and emotional cue reactivity (B4), which could be due to high cortisol levels present in a female-majority cohort. Network models also identified positive associations between CRP and waist circum-ference, blood pressure, and high-density lipoprotein cholesterol (HDL-C). The strongest association was observed between CRP and waist circumference, providing evidence that central obesity is an important in-flammatory component of MetS. Some networks displayed high instability, which could be due to the small pool of participants with viable cytokine data. Overall, this study provides evidence for associations between inflammation, PTS symptoms and components of MetS. Future longitudinal studies measuring pro-inflammatory cytokines in the immediate aftermath of trauma are required to gain better insight into the role of inflammation in trauma-exposure and PTSD.
C1 [Moodley, Allegra; Womersley, Jacqueline S.; Swart, Patricia C.; van den Heuvel, Leigh L.; Malan-Muller, Stefanie; Seedat, Soraya; Hemmings, Sian M. J.] Stellenbosch Univ, Dept Psychiat, Cape Town, South Africa.
   [Moodley, Allegra] Stellenbosch Univ, Dept Biomed Sci, Cape Town, South Africa.
   [Moodley, Allegra; Womersley, Jacqueline S.; Swart, Patricia C.; van den Heuvel, Leigh L.; Malan-Muller, Stefanie; Seedat, Soraya; Hemmings, Sian M. J.] Stellenbosch Univ, South African Med Res Council, Extramural Unit Genom Brain Disorders, Dept Psychiat, Cape Town, South Africa.
   [Malan-Muller, Stefanie] Univ Complutense Madrid UCM, Fac Med, Dept Pharmacol & Toxicol, Madrid, Spain.
   [Malan-Muller, Stefanie] Inst Hlth Carlos III, Biomed Network Res Ctr Mental Hlth CIBERSAM, Madrid, Spain.
   [Malan-Muller, Stefanie] Hosp 12 Octubre Res Inst Imas12, Neurochem Res Inst UCM, Madrid, Spain.
   [Moodley, Allegra] Univ Cape Town, Neurosci Inst, Dept Psychiat & Mental Hlth, Cape Town, South Africa.
C3 Stellenbosch University; Stellenbosch University; South African Medical
   Research Council; Stellenbosch University; Complutense University of
   Madrid; CIBER - Centro de Investigacion Biomedica en Red; CIBERSAM;
   University of Cape Town
RP Hemmings, SMJ (corresponding author), Stellenbosch Univ, Dept Psychiat, Cape Town, South Africa.; Hemmings, SMJ (corresponding author), Stellenbosch Univ, South African Med Res Council, Extramural Unit Genom Brain Disorders, Dept Psychiat, Cape Town, South Africa.
EM smjh@sun.ac.za
RI Hemmings, Sian/ABF-9676-2022; van den Heuvel, L.P.W.J./H-8044-2014;
   Womersley, Jacqueline/AAD-9579-2019
OI van den Heuvel, Leigh/0000-0003-3884-4754; Womersley,
   Jacqueline/0000-0001-9731-4505; Swart, Patricia/0000-0001-8249-6895;
   Hemmings, Sian/0000-0001-8461-1017; Moodley,
   Allegra/0000-0002-8264-1594; Malan-Muller, Stefanie/0000-0003-0639-0129;
   Seedat, Soraya/0000-0002-5118-786X
FU South African Medical Research Council (SAMRC)
   [MRC-RFA-IFSP-01-2013/SHARED ROOTS]; National Research Foundation (NRF);
   SAMRC CLINICIAN RESEARCHER (M.D PHD) SCHOLARSHIP PROGRAMME
FX This work was supported by the South African Medical Research Council
   (SAMRC) for the SHARED ROOTS Flagship Project (SHARED ROOTS, grant
   number MRC-RFA-IFSP-01-2013/SHARED ROOTS) (Soraya Seedat); National
   Research Foundation (NRF) Masters Scholarship (Allegra Moodley); and the
   SAMRC CLINICIAN RESEARCHER (M.D PHD) SCHOLARSHIP PROGRAMME (Leigh van
   den Heuvel). Funding sources did not play a role in the study design;
   collection, analysis and interpretation of data; writing of the report;
   or in the decision to submit the article for publication. The content
   hereof is the sole responsibility of the authors and do not necessarily
   represent the official views of the SAMRC or NRF.
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NR 61
TC 4
Z9 5
U1 3
U2 11
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-3956
EI 1879-1379
J9 J PSYCHIATR RES
JI J. Psychiatr. Res.
PD SEP
PY 2023
VL 165
BP 105
EP 114
DI 10.1016/j.jpsychires.2023.07.018
EA JUL 2023
PG 10
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA Q4WE6
UT WOS:001057532000001
PM 37487292
OA hybrid
DA 2025-06-11
ER

PT J
AU Pingle, YP
   Ragha, LK
AF Pingle, Yogesh Prabhakar
   Ragha, Lakshmappa K.
TI An in-depth analysis of music structure and its effects on human body
   for music therapy
SO MULTIMEDIA TOOLS AND APPLICATIONS
LA English
DT Article; Early Access
DE Music therapy; Emotions; Classification; Artificial intelligence;
   Recommendation
ID DEMENTIA; CHILDREN; ANXIETY; STROKE; MEDICINE
AB Music therapy is a therapeutic strategy that uses the natural mood enhancing feature of music to help patients improve their mental health. The music therapist employs a variety of therapies, which can be grouped into two main groups: active interventions and passive interventions. Passive music therapy strategies allow the patient to listen live or recorded music, while active methods engage the patient to sing, compose, or play an instrument. Natural sounds, classical music, or Western music can help patients feel less anxious by lowering cortisol levels, blood pressure, and heart rate. The frequency and length of each music therapy session might vary greatly depending on the desired result, the patient's preferences, and the environment in which the therapy is provided. This paper provides the frequencies for swaras of both classical music and western music to carefully study the frequency difference between the music. Also, it studies the Indian Classical Ragas Structure and its Influence on Human Body for Music Therapy. This investigation has explicitly demonstrated that different ragas can generate different emotions and examined the significance of various music for metabolic syndrome. Finally, it identifies the need for AI to provide valuable information and recommendations for patients. This study can be used to increase the understanding ability of researchers regarding music therapy and its effects related to different diseases.
C1 [Pingle, Yogesh Prabhakar; Ragha, Lakshmappa K.] Terna Engn Coll, Dept Comp Engn, Mumbai 400706, India.
RP Pingle, YP (corresponding author), Terna Engn Coll, Dept Comp Engn, Mumbai 400706, India.
EM yogeshpingle1977@gmail.com
RI Pingle, Yogesh/AAT-2283-2020
OI Pingle, Yogesh/0000-0003-2124-885X
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   Zanini C, 2018, J HYPERTENS, V36, pE260
NR 72
TC 1
Z9 2
U1 15
U2 43
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1380-7501
EI 1573-7721
J9 MULTIMED TOOLS APPL
JI Multimed. Tools Appl.
PD 2023 OCT 16
PY 2023
DI 10.1007/s11042-023-17290-w
EA OCT 2023
PG 24
WC Computer Science, Information Systems; Computer Science, Software
   Engineering; Computer Science, Theory & Methods; Engineering, Electrical
   & Electronic
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Computer Science; Engineering
GA EY6P9
UT WOS:001142539400013
DA 2025-06-11
ER

PT J
AU Jakovljevic, M
   Ostojic, L
AF Jakovljevic, Miro
   Ostojic, Ljerka
TI COMORBIDITY AND MULTIMORBIDITY IN MEDICINE TODAY: CHALLENGES AND
   OPPORTUNITIES FOR BRINGING SEPARATED BRANCHES OF MEDICINE CLOSER TO EACH
   OTHER
SO PSYCHIATRIA DANUBINA
LA English
DT Review
DE comorbidity; multimorbidity; explanatory models; individualized and
   person-centered medicine
ID METABOLIC SYNDROME; CO-MORBIDITY; DEPRESSION; CLASSIFICATION;
   PREVALENCE; PSYCHIATRY; SCHIZOPHRENIA; INFLAMMATION; CRITERIA; STRESS
AB Comorbidity and multimorbidity represent one of the greatest chalenge to academic medicine. Many disorders are often comorbidly expressed in diverse combinations. In clinical practice comorbidity and multimorbidity are underrecognized, underdiagnosed, underestimated and undertreated. So that one can speak about comorbidity and multimorbidity anosognosia. Comorbidities and multimorbidities are indifferent to medical specializations, so the integrative and complementary medicine is an imperative in the both education and practice. Shifting the paradigm from vertical/mono-morbid interventions to comorbidity and multimorbidity approaches enhances effectiveness and efficiency of human resources utilization. Comorbidity and multimorbidity studies have been expected to be an impetus to research on the validity of current diagnostic systems as well as on establishing more effective and efficient treatment including individualized and personalized pharmacotherapy.
C1 [Jakovljevic, Miro; Ostojic, Ljerka] Univ Mostar, Sch Med, Mostar 88000, Bosnia & Herceg.
C3 University of Mostar
RP Jakovljevic, M (corresponding author), Univ Mostar, Sch Med, Mostar 88000, Bosnia & Herceg.
EM predstojnik_psi@kbc-zagreb.hr
RI Ostojic, Ljerka/D-8355-2017
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NR 62
TC 73
Z9 88
U1 0
U2 9
PU MEDICINSKA NAKLADA
PI ZAGREB
PA VLASKA 69, HR-10000 ZAGREB, CROATIA
SN 0353-5053
J9 PSYCHIAT DANUB
JI Psychiatr. Danub.
PY 2013
VL 25
SU 1
BP 18
EP 28
PG 11
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA AK7TZ
UT WOS:000338631900004
PM 23806971
DA 2025-06-11
ER

PT J
AU Kang, LL
   Zhang, DM
   Ma, CH
   Zhang, JH
   Jia, KK
   Liu, JH
   Wang, R
   Kong, LD
AF Kang, Lin-Lin
   Zhang, Dong-Mei
   Ma, Chun-Hua
   Zhang, Jian-Hua
   Jia, Ke-Ke
   Liu, Jia-Hui
   Wang, Rong
   Kong, Ling-Dong
TI Cinnamaldehyde and allopurinol reduce fructose-induced cardiac
   inflammation and fibrosis by attenuating CD36-mediated TLR4/6-IRAK4/1
   signaling to suppress NLRP3 inflammasome activation
SO SCIENTIFIC REPORTS
LA English
DT Article
ID LOW-DENSITY-LIPOPROTEIN; XANTHINE-OXIDASE; URIC-ACID; DIASTOLIC
   DYSFUNCTION; INHIBITS INFLAMMATION; LIPID-ACCUMULATION; METABOLIC
   SYNDROME; TXNIP EXPRESSION; ESSENTIAL OIL; CD36
AB Fructose consumption induces metabolic syndrome to increase cardiovascular disease risk. Cinnamaldehyde and allopurinol possess anti-oxidative and anti-inflammatory activity to relieve heart injury in metabolic syndrome. But the mechanisms of fructose-induced cardiac injury, and cardioprotective effects of cinnamaldehyde and allopurinol are not completely understood. In this study, fructose-fed rats displayed metabolic syndrome with elevated serum ox-LDL, cardiac oxidative stress, inflammation and fibrosis. Scavenger receptor CD36, Toll-like receptor 4 (TLR4), TLR6, IL-1R-associated kinase 4/1 (IRAK4/1), nucleotide-binding domain (NOD)-like receptor protein 3 (NLRP3) inflammasome, interleukin-1 beta, transforming growth factor-beta (TGF-beta), drosophila mothers against DPP homolog (Smad) 2/3 phosphorylation and Smad4 were increased in animal and H9c2 cell models. These pathological processes were further evaluated in ox-LDL or fructose-exposed H9c2 cells pretreated with ROS scavenger and CD36 specific inhibitor, or IRAK1/4 inhibitor, and transfected with CD36, NLRP3, or IRAK4/1 siRNA, demonstrating that NLPR3 inflammasome activation through CD36-mediated TLR4/6-IRAK4/1 signaling may promote cardiac inflammation and fibrosis. Cinnamaldehyde and allopurinol reduced cardiac oxidative stress to suppress NLPR3 inflammasome activation and TGF-beta/Smads signaling by inhibiting CD36-mediated TLR4/6-IRAK4/1 signaling under fructose induction. These results suggest that the blockage of CD36-mediated TLR4/6-IRAK4/1 signaling to suppress NLRP3 inflammasome activation by cinnamaldehyde and allopurinol may protect against fructose-induced cardiac inflammation and fibrosis.
C1 [Kang, Lin-Lin; Zhang, Dong-Mei; Ma, Chun-Hua; Zhang, Jian-Hua; Jia, Ke-Ke; Liu, Jia-Hui; Wang, Rong; Kong, Ling-Dong] Nanjing Univ, State Key Lab Pharmaceut Biotechnol, Sch Life Sci, Nanjing 210008, Jiangsu, Peoples R China.
C3 Nanjing University
RP Kong, LD (corresponding author), Nanjing Univ, State Key Lab Pharmaceut Biotechnol, Sch Life Sci, Nanjing 210008, Jiangsu, Peoples R China.
EM kongld@nju.edu.cn
RI zhang, dongmei/B-8011-2013; Ma, Chunhua/NFS-9026-2025
FU National Natural Science Foundation of China [81025025, 81373788,
   J1210026]; Program for Changjiang Scholars and Innovative Research Team
   in University [IRT 14R27]
FX This work was supported by Grants from National Natural Science
   Foundation of China (Nos 81025025, 81373788, J1210026) and the Program
   for Changjiang Scholars and Innovative Research Team in University (IRT
   14R27) to Ling-Dong Kong.
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TC 101
Z9 105
U1 0
U2 44
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD JUN 8
PY 2016
VL 6
AR 27460
DI 10.1038/srep27460
PG 18
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA DO0IL
UT WOS:000377462500001
PM 27270216
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Demir, B
   Ozyazgan, S
   Korkmaz, GG
   Karakaya, O
   Aciksari, G
   Uygun, T
   Onal, B
   Uzun, H
AF Demir, B.
   Ozyazgan, S.
   Korkmaz, G. G.
   Karakaya, O.
   Aciksari, G.
   Uygun, T.
   Onal, B.
   Uzun, H.
TI The Relationship between Ischemia Modified Albumin and Oxidative Stress
   Parameters in Patients with Cardiac Syndrome X
SO CLINICAL LABORATORY
LA English
DT Article
DE cardiac syndrome X; ischemia modified albumin; oxidative stress;
   coronary angiography
ID CORONARY MICROVASCULAR DYSFUNCTION; C-REACTIVE-PROTEIN; STABLE
   ANGINA-PECTORIS; MYOCARDIAL-ISCHEMIA; ARTERY-DISEASE; CHEST-PAIN;
   CLINICAL PRESENTATION; MARKER; WOMEN; PATHOPHYSIOLOGY
AB Background: The objective of this study was to evaluate the serum levels of ischemia modified albumin and oxidative stress parameters in patients with cardiac syndrome X.
   Methods: A total of 61 patients, composed of 32 consecutive patients (24 female, 8 male, average age: 47.63 +/- 9.49 years) diagnosed with cardiac syndrome X by coronary angiography (initially performed following the identification of ischemia by exercise stress test or myocardial perfusion scintigraphy) and a control group of 29 consecutive patients (15 female, 14 male, average age: 49.59 +/- 11.68 years) with similar features without cardiac syndrome X were included in the study. The levels of the ischemia modified albumin (IMA), ferric reducing antioxidant power (FRAP), prooxidant-antioxidant balance (PAB), and advanced protein oxidation products (AOPP) were determined by colorimetric methods.
   Results: Patients have significantly higher PAB, AOPP, and IMA levels in the patient group than in the control group (p < 0.01, p < 0.001, and p < 0.02, respectively). Also, serum triglyceride (p < 0.005) and hs-CRP (p < 0.0001) levels were significantly higher in the patient group (p < 0.01, p < 0.001, and p < 0.02, respectively). We found that there was a significant correlation between hs-CRP, plasma PAB (r: 0.258; p < 0.05), AOPP (r: 0.459; p < 0.001), and triglyceride levels (r: 0.404; p < 0.01). Plasma AOPP levels were also significantly positive correlated with triglyceride levels (r: 0.463; p < 0.001). In addition, during the correlation analysis performed on the patient group, a positive correlation was observed between the levels of IMA with the levels of plasma PAB and plasma AOPP (r: 0,994; p < 0.01 and r: 0.857; p < 0.05, respectively) In a multiple linear regression analysis, AOPP levels were significantly related with hs-CRP and triglyceride (R-2: 0.380, p < 0.0001 and p < 0.05). Simple linear regression analysis was performed between plasma PAB (as dependent variable) and hs-CRP levels. Plasma PAB levels were related with hs-CRP (R-2: 0.258, p < 0.05). Using the receiver-operator characteristic (ROC) curve, the best cut-off values for predicting cardiac syndrome X of PAD, AOPP, IMA, and hs-CRP levels were 88.1 arbitrary units, 68.5 kloramin T mu mol/L, 7.17 U/mL, and 1.09 mg/dL, respectively.
   Conclusions: Based on the results of our study, the increase in oxidative stress during cardiac syndrome X appears to be related to elevated levels of IMA. Treatment modalities that decrease oxidative stress might be beneficial for the treatment of cardiac syndrome X.
C1 [Demir, B.; Karakaya, O.; Aciksari, G.; Uygun, T.] Bakirkoy Dr Sadi Konuk Educ & Res Hosp, Dept Cardiol, Istanbul, Turkey.
   [Ozyazgan, S.; Onal, B.] Istanbul Univ, Cerrahpasa Fac Med, Dept Med Pharmacol & Clin Pharmacol, TR-34303 Istanbul, Turkey.
   [Korkmaz, G. G.] Kirklareli Univ, Sch Hlth, Kirklareli, Turkey.
   [Uzun, H.] Istanbul Univ, Cerrahpasa Fac Med, Dept Med Biochem, TR-34303 Istanbul, Turkey.
C3 Bakirkoy Dr. Sadi Konuk Research & Training Hospital; Istanbul
   University; Istanbul University - Cerrahpasa; Kirklareli University;
   Istanbul University; Istanbul University - Cerrahpasa
RP Ozyazgan, S (corresponding author), Istanbul Univ, Cerrahpasa Fac Med, Dept Pharmacol & Clin Pharmacol, TR-34303 Istanbul, Turkey.
EM ozyazgans@yahoo.com
RI Özyazgan, Sibel/C-7404-2019; aciksari, gonul/LXW-1995-2024; Karakaya,
   Osman/KPB-5126-2024; Uzun, Hafize/D-4811-2019; Guntas,
   Gulcan/B-9262-2014
OI Uzun, Hafize/0000-0002-1347-8498; Aciksari, Gonul/0000-0002-8380-3065;
   Ozyazgan, Sibel/0000-0002-2511-3541; Onal, Burak/0000-0002-7846-875X;
   Guntas, Gulcan/0000-0002-3638-4662
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NR 39
TC 6
Z9 8
U1 0
U2 4
PU CLIN LAB PUBL
PI HEIDELBERG
PA IM BREITSPIEL 15, HEIDELBERG, D-69126, GERMANY
SN 1433-6510
J9 CLIN LAB
JI Clin. Lab.
PY 2013
VL 59
IS 11-12
BP 1319
EP 1329
DI 10.7754/Clin.Lab.2013.121142
PG 11
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA 276CG
UT WOS:000328725100015
PM 24409667
DA 2025-06-11
ER

PT J
AU Awan, UN
   Waraich, RS
   Noor, SS
   Siddiqui, IA
   Nangrejo, R
AF Awan, Uzma Naseer
   Waraich, Rizwana Sanaullah
   Noor, Syed Shahid
   Siddiqui, Iftikhar Ahmed
   Nangrejo, Ruqaya
TI Correlation of radiographic and histopathological changes with IL-17 and
   advanced oxidation protein products in knee osteoarthritic individuals
   with metabolic syndrome
SO INNOVATIVE SURGICAL SCIENCES
LA English
DT Article; Early Access
DE metabolic syndrome; infrapatellar fat pad; advanced oxidation protein
   products; interleukin-17; inflammation; oxidative stress
ID CARTILAGE; SEVERITY
AB Objectives Recent studies show that osteoarthritis and metabolic syndrome (MetS) represent significant global health concerns, sharing common pathological processes involving inflammation and oxidative stress. The study aimed to compare the radiological and histological severity of osteoarthritis in patients with and without MetS and further correlates them with oxidative stress and inflammatory markers in serum and synovial fluid (SF). Hypothesis: The study hypothesized that IL-17 and advanced oxidation protein products (AOPPs) are correlated with OA severity and progression in MetS patients. Methods This cross-sectional study included 78 patients of advanced knee osteoarthritis, 40 with MetS and 38 without, matched for age. Clinical history and anthropometric measurements were recorded, and presurgical knee X-rays were evaluated using the Kellgren-Lawrence system. Histological grading of hematoxylin & eosin stained infrapatellar fat pad (IFP) and cartilage sections was performed. AOPPs and Interleukin-17 levels were measured in serum and SF, employing sandwich enzyme-linked immunosorbent assay. Results In the MetS group, the severity of osteoarthritis was higher compared to non-MetS group, as evidenced by histological evaluation of the articular cartilage and IFP (p<0.05). The histological grading of IFP demonstrated positive correlation (p<0.05) with histological cartilage grade. Additionally, it exhibited a positive correlation with interleukin-17 and AOPPs in both SF and serum (p<0.05). While histological cartilage grade showed a positive correlation with AOPPs concentration in the serum and SF (p<0.05). Conclusions MetS accelerates osteoarthritis progression, and positive correlation between molecular markers and histological severity suggests the contribution of inflammation and oxidative stress in the disease's pathogenesis.
C1 [Awan, Uzma Naseer] Baqai Med Univ, Dept Anat, Karachi, Pakistan.
   [Waraich, Rizwana Sanaullah] Sohail Univ, Biomed Res Ctr, Dept Biomed & Biol Sci, Karachi 78400, Pakistan.
   [Noor, Syed Shahid] Medicare Cardiac & Gen Hosp, Dept Orthoped, Karachi, Pakistan.
   [Siddiqui, Iftikhar Ahmed] Baqai Med Univ, Karachi, Pakistan.
   [Nangrejo, Ruqaya] Baqai Med Univ, Dept Physiol, Karachi, Pakistan.
C3 Baqai Medical University; Baqai Medical University; Baqai Medical
   University
RP Waraich, RS (corresponding author), Sohail Univ, Biomed Res Ctr, Dept Biomed & Biol Sci, Karachi 78400, Pakistan.
EM rizwanas.waraich@sohailuniversity.edu.pk
RI Nangrejo, Ruqaya/JJC-7021-2023; waraich, rizwana/A-8470-2012
FU Microscope Imaging Facility at the International Center for Chemical and
   Biological Sciences, University of Karachi
FX We thank Ms. Gul Naz Khan for her technical assistance and the
   Microscope Imaging Facility at the International Center for Chemical and
   Biological Sciences, University of Karachi, for their role in
   photomicrography.
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NR 35
TC 0
Z9 0
U1 0
U2 0
PU WALTER DE GRUYTER GMBH
PI BERLIN
PA GENTHINER STRASSE 13, D-10785 BERLIN, GERMANY
SN 2364-7485
J9 INNOV SURG SCI
JI Innov. Surg. Sci.
PD 2025 FEB 10
PY 2025
DI 10.1515/iss-2024-0037
EA FEB 2025
PG 10
WC Surgery
WE Emerging Sources Citation Index (ESCI)
SC Surgery
GA W1C1K
UT WOS:001416029500001
OA gold
DA 2025-06-11
ER

PT J
AU Tunç-Ata, M
   Dönmez, AÇ
   Dönmez, BÖ
   Akbudak, IH
   Küçükatay, V
AF Tunc-Ata, Melek
   Donmez, Aysegul Cort
   Donmez, Baris Ozgur
   Akbudak, Ismail Hakki
   Kucukatay, Vural
TI Ileal interposition reduces oxidative stress via oxidant-antioxidant
   enzymes in rats with metabolic syndrome
SO CUKUROVA MEDICAL JOURNAL
LA English
DT Article
DE &nbsp; Metabolic syndrome; ileal interposition; oxidative stress;
   monosodium glutamate
ID BARIATRIC SURGERY; INSULIN-RESISTANCE; MEDICAL THERAPY; WEIGHT-LOSS;
   OBESITY; ASSOCIATION; EXPRESSION
AB Purpose: This study aims to examine the effect of ileal transposition (IT) on plasma levels of the total antioxidant status (TAS), total oxidant status (TOS), Oxidative Stress Index (OSI), Superoxide dismutase (SOD), Nicotinamide adenine dinucleotide phosphate oxidase (NOX), Catalase (CAT), Reduced Glutathione (GSH) in both rats with Metabolic syndrome (MetS) and healthy controls. Materials and Methods: In the MetS model, newborn male Wistar albino rats were given MSG (4 g/mg) on days 0, 2, 4, 6, 8, and 10. The control group was injected only saline. In the 5th month, sham and IT animals underwent selected surgery. 2 months after surgery TOS, TAS, OSI, SOD, NOX, CAT, and GSH levels were assessed in the plasma. Results: IT procedure significantly increased SOD and CAT levels in MetS + IT group when compared to the MetS group (SOD; MetS 1.75 +/- 0.04, MetS+IT 2.1 +/- 0.15, CAT; MetS 32.02 +/- 1.73, MetS+IT 41.64 +/- 1.18,). As expected, while GSH levels was increased in MetS+IT rats compared to MetS rats, but the difference was not significant (MetS 243.31 +/- 6.36, MetS+IT 269.76 +/- 9.17). The NOX activity was significantly lower in MetS+IT group than MetS and MetS+S groups (MetS 610.35 +/- 26.25, MetS+IT 348.86 +/- 14.12). Conclusion: These data revealed the healing effect of IT surgery against oxidative stress associated with MetS. The available data endorses IT surgery as an effective strategy to reduce oxidative damage in rats with MetS by modulating systemic oxidant and antioxidant responses.
C1 [Tunc-Ata, Melek; Kucukatay, Vural] Pamukkale Univ, Med Fac, Dept Physiol, Denizli, Turkey.
   [Donmez, Aysegul Cort] Pamukkale Univ, Med Fac, Dept Biochem, Denizli, Turkey.
   [Donmez, Baris Ozgur] Pamukkale Univ, Med Fac, Dept Anat, Denizli, Turkey.
   [Akbudak, Ismail Hakki] Pamukkale Univ, Med Fac, Dept Internal Med, Denizli, Turkey.
C3 Pamukkale University; Pamukkale University; Pamukkale University;
   Pamukkale University
RP Tunç-Ata, M (corresponding author), Pamukkale Univ, Med Fac, Dept Physiol, Denizli, Turkey.
EM melekt@pau.edu.tr
RI Donmez, Baris/JWO-7265-2024; Kucukatay, Vural/ABI-6427-2020; Cort
   Donmez, Aysegul/HJY-8866-2023
FU Pamukkale University [2020HZDP005, 2019BSP002, 2020HZDP007]
FX This study was supported by Pamukkale University (Project no
   2020HZDP005, 2019BSP002, 2020HZDP007).
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NR 42
TC 0
Z9 0
U1 0
U2 1
PU CUKUROVA UNIV, FAC MEDICINE
PI ADANA
PA YAYIN VE DOKUMENTASYON KURULU, BALCALI, ADANA, 01330, TURKEY
SN 2602-3032
EI 2602-3040
J9 CUKUROVA MED J
JI Cukurova Med. J.
PY 2022
VL 47
IS 2
BP 820
EP 827
DI 10.17826/cumj.1029295
PG 8
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA 2J2GG
UT WOS:000815481700040
DA 2025-06-11
ER

PT J
AU Mohammad-Sadeghipour, M
   Afsharinasab, M
   Mohamadi, M
   Mahmoodi, M
   Falahati-pour, SK
   Hajizadeh, MR
AF Mohammad-Sadeghipour, Maryam
   Afsharinasab, Mehdi
   Mohamadi, Maryam
   Mahmoodi, Mehdi
   Falahati-pour, Soudeh Khanamani
   Hajizadeh, Mohammad Reza
TI The Effects of Hydro-Alcoholic Extract of Fenugreek Seeds on the Lipid
   Profile and Oxidative Stress in Fructose-Fed Rats
SO JOURNAL OF OBESITY & METABOLIC SYNDROME
LA English
DT Article
DE Antioxidants; Dyslipidemia; Trigonella; Metabolic syndrome; Oxidative
   stress
ID FOENUM-GRAECUM FENUGREEK; TYPE-2 DIABETES-MELLITUS; METABOLIC SYNDROME;
   BIOMARKERS; POWDER; HYPERTENSION; INFLAMMATION; ASSOCIATION; OBESITY; L.
AB Background: Metabolic syndrome (MetS) is a complex clinical disorder that can lead to an increase in oxidative stress. Patients with this syndrome are at risk of diabetes and cardiovascular disease. The Trigonella foenumgraecum L. (fenugreek) plant has many therapeutic effects, including anti-diabetic and antioxidant. The present study aimed to investigate the effects of the hydro-alcoholic extract of fenugreek seeds (HEFS) on dyslipidemia and oxidative stress due to high-fructose diet-induced MetS.
   Methods: In this experimental study, to induce MetS, animals received water containing 20% fructose for 8 weeks. After induction of MetS, 48 male Wistar rats (200-250 g) were randomized into six groups. HEFS was administered to animals at doses of 100 and 200 mg/kg orally for 4 weeks. Animal blood samples were collected to measure biochemical and antioxidant parameters of fasting plasma glucose (FPG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), malondialdehyde (MDA), glutathione peroxidase (GPX), catalase (CAT), and total antioxidant capacity (TAC).
   Results: The findings showed that the serum levels of FPG, TC, LDL-C, TG, and MDA were significantly reduced in HEFS-exposed groups compared with the control group (P<0.05). Also, significant increases in HDL-C, GPX, CAT, and TAC levels (P<0.05) were observed.
   Conclusion: Our results revealed that treatment with HEFS increases the levels of antioxidant enzymes, decreases FPG level, and at the same time, modifies the lipid profile in MetS. Therefore, HEFS may help to alleviate the risk of some chronic complications of this disease.
C1 [Mohammad-Sadeghipour, Maryam] Kerman Univ Med Sci, Student Res Comm, Afzalipour Sch Med, Kerman, Iran.
   [Mohammad-Sadeghipour, Maryam; Mahmoodi, Mehdi] Kerman Univ Med Sci, Afzalipour Sch Med, Dept Clin Biochem, Kerman, Iran.
   [Afsharinasab, Mehdi; Hajizadeh, Mohammad Reza] Rafsanjan Univ Med Sci, Fac Med, Dept Clin Biochem, Rafsanjan, Iran.
   [Afsharinasab, Mehdi; Mohamadi, Maryam; Hajizadeh, Mohammad Reza] Rafsanjan Univ Med Sci, Inst Basic Med Sci Res, Mol Med Res Ctr, Rafsanjan, Iran.
   [Falahati-pour, Soudeh Khanamani] Rafsanjan Univ Med Sci, Pistachio Safety Res Ctr, Rafsanjan, Iran.
C3 Kerman University of Medical Sciences; Kerman University of Medical
   Sciences
RP Hajizadeh, MR (corresponding author), Rafsanjan Univ Med Sci, Mol Med Res Ctr, Rafsanjan 7719617996, Iran.
EM hajizadehus@yahoo.com
RI Mahmoodi, Mehdi/H-2754-2017; Falahati, Soudeh/M-3678-2017;
   Mohammad-Sadeghipour, Maryam/AAX-6052-2021; Mohamadi, Maryam/N-3628-2017
OI Mahmoodi, Mehdi/0000-0002-8463-8364
FU RUMS [20.198]
FX The authors are thankful for the support by RUMS under grant number
   20.198.
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NR 57
TC 6
Z9 6
U1 2
U2 5
PU KOREAN SOC STUDY OBESITY
PI SEOUL
PA RENAISSANCE TOWER, 1010  14 MALLIJAE-RO, MAPO-GU, SEOUL, 04195, SOUTH
   KOREA
SN 2508-6235
EI 2508-7576
J9 J OBES METAB SYNDR
JI J. Obes. Metab. Syndr.
PD SEP
PY 2020
VL 29
IS 3
BP 198
EP 207
DI 10.7570/jomes19051
PG 10
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA NY5NI
UT WOS:000576435600006
PM 32883888
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Zák, A
   Jáchymová, M
   Burda, M
   Stanková, B
   Zeman, M
   Slaby, A
   Vecka, M
   Seda, O
AF Zak, Ales
   Jachymova, Marie
   Burda, Michal
   Stankova, Barbora
   Zeman, Miroslav
   Slaby, Adolf
   Vecka, Marek
   Seda, Ondrej
TI FADS Polymorphisms Affect the Clinical and Biochemical Phenotypes of
   Metabolic Syndrome
SO METABOLITES
LA English
DT Article
DE metabolic syndrome; fatty acid pattern; cluster analysis;
   single-nucleotide polymorphism; haplotypes; FADS1; FADS2
ID FATTY-ACID-COMPOSITION; ESTIMATED DESATURASE ACTIVITIES; GENE-CLUSTER;
   ARACHIDONIC-ACID; OXIDATIVE STRESS; HDL-CHOLESTEROL; LINOLEIC-ACID;
   ASSOCIATION; DELTA-6; VARIANTS
AB Long-chain polyunsaturated fatty acids (LC-PUFAs) play important roles in human health, from controlling inflammation to lipid and glucose homeostasis. In our previous study, which employed a cluster analysis of a plasma fatty acid (FA) pattern, we identified two clusters of metabolic syndrome (MetS) independent of clinical and biochemical parameters within the whole study group (controls together with metabolic syndrome (MetS) patients). FA desaturase (FADS) genes are the key regulators of LC-PUFA metabolism. The aim of this study was to analyze associations between FADS polymorphisms and clusters of MetS. The study group consisted of 188 controls and 166 patients with MetS. The first cluster contained 71 controls (CON1) and 109 MetS patients (MetS1). The second cluster consisted of 117 controls (CON2) and 57 MetS patients (MetS2). In comparison with MetS2, cluster MetS1 displayed a more adverse risk profile. Cluster CON1 had, in comparison with CON2, higher body weight and increased triacylglycerol levels (p < 0.05). We found that the FADS rs174537 (p < 0.001), rs174570 (p < 0.01), and rs174602 (p < 0.05) polymorphisms along with two inferred haplotypes had statistically significant genotype associations with the splitting of MetS into MetS1 and MetS2. Conversely, we observed no significant differences in the distribution of FADS polymorphisms between MetS and CON subjects, or between CON1 and CON2. These associations between FADS polymorphisms and two clusters of MetS (differing in waist circumference, HOMA-IR, lipolysis, and oxidative stress) implicate the important influence of genetic factors on the phenotypic manifestation of MetS.
C1 [Zak, Ales; Stankova, Barbora; Zeman, Miroslav; Slaby, Adolf; Vecka, Marek] Charles Univ Prague, Med Fac 1, Dept Med 4, Prague 12808, Czech Republic.
   [Zak, Ales; Jachymova, Marie; Stankova, Barbora; Zeman, Miroslav; Slaby, Adolf; Vecka, Marek] Gen Univ Hosp Prague, Prague 12808, Czech Republic.
   [Jachymova, Marie; Vecka, Marek] Charles Univ Prague, Med Fac 1, Inst Clin Chem & Lab Diagnost, Prague 12808, Czech Republic.
   [Burda, Michal] Univ Ostrava, Inst Res & Applicat Fuzzy Modeling, Ostrava 70103, Czech Republic.
   [Seda, Ondrej] Charles Univ Prague, Med Fac 1, Inst Biol & Med Genet, Prague 12800, Czech Republic.
   [Seda, Ondrej] Gen Univ Hosp Prague, Prague 12800, Czech Republic.
C3 Charles University Prague; General University Hospital Prague; Charles
   University Prague; University of Ostrava; Charles University Prague;
   General University Hospital Prague
RP Vecka, M (corresponding author), Charles Univ Prague, Med Fac 1, Dept Med 4, Prague 12808, Czech Republic.; Vecka, M (corresponding author), Gen Univ Hosp Prague, Prague 12808, Czech Republic.; Vecka, M (corresponding author), Charles Univ Prague, Med Fac 1, Inst Clin Chem & Lab Diagnost, Prague 12808, Czech Republic.
EM zak.ales@email.cz; jachymova@yahoo.com; michal.burda@osu.cz;
   barsta@atlas.cz; miroslay.zeman@vfn.cz; adaslaby@seznam.cz;
   marek.vecka@lf1.cuni.cz; ondrej.seda@lftcuni.cz
RI Stankova, Barbora/L-7933-2016; Vecka, Marek/AAB-9358-2022; Vecka,
   Marek/A-3560-2008; Burda, Michal/D-6699-2014; Zak, Ales/G-8318-2016;
   Seda, Ondrej/A-2058-2008
OI Vecka, Marek/0000-0002-3269-1817; Burda, Michal/0000-0002-4182-4407;
   Zak, Ales/0000-0002-1698-6068; Seda, Ondrej/0000-0001-8498-5895
FU Ministry of Health of the Czech Republic [MHCZDRO-VFN64165]; Charles
   University Research program, Cooperatio-Gastroenterology
FX This research was funded by the Ministry of Health of the Czech
   Republic, grant number MHCZDRO-VFN64165, and the CharlesUniversity
   Research program, Cooperatio-Gastroenterology.
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NR 90
TC 6
Z9 6
U1 0
U2 6
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2218-1989
J9 METABOLITES
JI Metabolites
PD JUN
PY 2022
VL 12
IS 6
AR 568
DI 10.3390/metabo12060568
PG 21
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 2K5LX
UT WOS:000816378300001
PM 35736500
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Ragno, VM
   Zello, GA
   Klein, CD
   Montgomery, JB
AF Ragno, Valentina M.
   Zello, Gordon A.
   Klein, Colby D.
   Montgomery, Julia B.
TI From Table to Stable: A Comparative Review of Selected Aspects of Human
   and Equine Metabolic Syndrome
SO JOURNAL OF EQUINE VETERINARY SCIENCE
LA English
DT Review
DE Equine metabolic syndrome; Insulin dysregulation; Obesity;
   Metaflammation; Endocrinopathic laminitis
ID OBESITY-ASSOCIATED HYPERINSULINEMIA; SUBCUTANEOUS ADIPOSE-TISSUE;
   NECROSIS-FACTOR-ALPHA; INSULIN SENSITIVITY; OXIDATIVE STRESS;
   OMEGA-3-FATTY-ACID SUPPLEMENTATION; ENDOCRINOPATHIC LAMINITIS;
   ENDOTHELIN-1 EXPRESSION; INFLAMMATORY CYTOKINES; PROVISIONAL REPORT
AB Obesity data in people and companion animals are depicting a future of increasing morbidity, cost for society, and significant health and welfare concerns. Between 25 and 50% of cats, dogs, and horses in developed countries are overweight or obese, which mirrors the situation in humans. Equine metabolic syndrome (EMS) was named after human metabolic syndrome (MetS), which has about 30 years of lead in research efforts. Even though the complications of the two syndromes seem to grossly differ (cardiac vs. laminitis risk), a number of similar disease mechanisms are worthy of investigation. Since the first EMS consensus statement by the American College of Veterinary Internal Medicine in 2010, numerous studies have confirmed the link between insulin dysregulation and laminitis, even though the mechanisms are not fully understood. After the discovery of the role of adipokines in MetS, evidence about inflammatory mechanisms related to adiposity in rodent models, companion animals, horses, and humans is constantly increasing. Oxidative and dicarbonyl stress have been correlated with insulin dysregulation, obesity, and recently with laminitis. Vascular actions of insulin through nitric oxide, endothelin-1, and other mechanisms are being studied in horses and can provide a better understanding of laminitis pathophysiology. More research is needed on neuropathic mechanisms in insulindysregulated horses, which could be important in the pathogenesis of laminitis and laminitic pain. Human literature can provide viable material for novel studies in areas that have received limited attention, in addition to being valuable information for clients about the consequences of unhealthy management of their horses. (C) 2019 Elsevier Inc. All rights reserved.
C1 [Ragno, Valentina M.; Klein, Colby D.; Montgomery, Julia B.] Univ Saskatchewan, Dept Large Anim Clin Sci, WCVM, 52 Campus Dr, Saskatoon, SK S7N 5B4, Canada.
   [Zello, Gordon A.] Univ Saskatchewan, Coll Pharm & Nutr, Sect Nutr, Saskatoon, SK S7N 5E5, Canada.
C3 University of Saskatchewan; University of Saskatchewan
RP Ragno, VM (corresponding author), Univ Saskatchewan, Dept Large Anim Clin Sci, WCVM, 52 Campus Dr, Saskatoon, SK S7N 5B4, Canada.
EM valentina.ragno@usask.ca
RI Montgomery, Julia/AAG-2013-2019
OI Montgomery, Julia/0000-0003-1159-5794
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NR 118
TC 14
Z9 17
U1 0
U2 31
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0737-0806
EI 1542-7412
J9 J EQUINE VET SCI
JI J. Equine Vet. Sci.
PD AUG
PY 2019
VL 79
BP 131
EP 138
DI 10.1016/j.jevs.2019.06.003
PG 8
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA IQ0AK
UT WOS:000480412000023
PM 31405493
DA 2025-06-11
ER

PT J
AU de Kreutzenberg, SV
   Ceolotto, G
   Papparella, I
   Bortoluzzi, A
   Semplicini, A
   Dalla Man, C
   Cobelli, C
   Fadini, GP
   Avogaro, A
AF de Kreutzenberg, Saula Vigili
   Ceolotto, Giulio
   Papparella, Italia
   Bortoluzzi, Alessia
   Semplicini, Andrea
   Dalla Man, Chiara
   Cobelli, Claudio
   Fadini, Gian Paolo
   Avogaro, Angelo
TI Downregulation of the Longevity-Associated Protein Sirtuin 1 in Insulin
   Resistance and Metabolic Syndrome: Potential Biochemical Mechanisms
SO DIABETES
LA English
DT Article
ID CALORIE RESTRICTION; SUBCLINICAL ATHEROSCLEROSIS; NUTRIENT AVAILABILITY;
   MONONUCLEAR-CELLS; OXIDATIVE STRESS; MINIMAL MODEL; GLUCOSE;
   SENSITIVITY; DEACETYLASE; TARGETS
AB OBJECTIVE-Sirtuins (SIRTs) are NAD(+)-dependent deacetylases that regulate metabolism and life span. We used peripheral blood mononuclear cells (PBMCs) to determine ex vivo whether insulin resistance/metabolic syndrome influences SIRTs. We also assessed the potential mechanisms linking metabolic alterations to SIRTs in human monocytes (THP-1) in vitro.
   RESEARCH DESIGN AND METHODS-SIRT1-SIRT7 gene and protein expression was determined in PBMCs of 54 subjects (41 with normal glucose tolerance and 13 with metabolic syndrome). Insulin sensitivity was assessed by the minimal model analysis. Subclinical atherosclerosis was assessed by carotid intima-media thickness (IMT). In THP-1 cells exposed to high glucose or fatty acids in vitro, we explored SIRT1 expression, p53 acetylation, Jun NH(2)-terminal kinase (JNK) activation, NAD(+) levels, and nicotinamide phosphoribosyltransferase (NAMPT) expression. The effects of SIRT1 induction by resveratrol and of SIRT1 gene silencing were also assessed.
   RESULTS-In vivo, insulin resistance and metabolic syndrome were associated with low PBMC SIRT1 gene and protein expression. SIRT1 gene expression was negatively correlated with carotid IMT. In THP-1 cells, high glucose and palmitate reduced SIRT1 and NAMPT expression and reduced the levels of intracellular NAD(+) through oxidative stress. No effect was observed in cells exposed to linoleate or insulin. High glucose and palmitate increased p53 acetylation and JNK phosphorylation; these effects were abolished in siRNA SIRT1-treated cells. Glucose- and palmitate-mediated effects on NAMPT and SIRT1 were prevented by resveratrol in vitro.
   CONCLUSIONS-Insulin resistance and subclinical atherosclerosis are associated with SIRT1 downregulation in monocytes. Glucotoxicity and lypotoxicity play a relevant role in quenching SIRT1 expression. Diabetes 59:1006-1015, 2010
C1 [de Kreutzenberg, Saula Vigili; Ceolotto, Giulio; Papparella, Italia; Bortoluzzi, Alessia; Semplicini, Andrea; Fadini, Gian Paolo; Avogaro, Angelo] Univ Padua, Dept Clin & Expt Med, Padua, Italy.
   [Dalla Man, Chiara; Cobelli, Claudio] Univ Padua, Dept Informat Engn, Padua, Italy.
C3 University of Padua; University of Padua
RP de Kreutzenberg, SV (corresponding author), Univ Padua, Dept Clin & Expt Med, Padua, Italy.
EM sauladekreutzenberg@unipd.it
RI Fadini, Gian/M-4575-2019; Avogaro, Angelo/S-3808-2016; Semplicini,
   Andrea/B-5959-2013
OI FADINI, GIAN PAOLO/0000-0002-6510-2097; Ceolotto,
   Giulio/0000-0002-4687-8033; Semplicini, Andrea/0000-0003-0652-0739;
   bortoluzzi, alessia/0000-0003-3330-4265; AVOGARO,
   ANGELO/0000-0002-1177-0516; DALLA MAN, CHIARA/0000-0002-4908-0596
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NR 44
TC 258
Z9 270
U1 0
U2 19
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0012-1797
J9 DIABETES
JI Diabetes
PD APR
PY 2010
VL 59
IS 4
BP 1006
EP 1015
DI 10.2337/db09-1187
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 582MH
UT WOS:000276601200026
PM 20068143
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Muñoz-Torrero, JFS
   Rivas, D
   Alonso, R
   Crespo, L
   Costo, A
   Roman, M
   Martín, C
   Zamorano, J
AF Sanchez Munoz-Torrero, Juan Francisco
   Rivas, Dolores
   Alonso, Rodrigo
   Crespo, Leandro
   Costo, Alberto
   Roman, Montana
   Martin, Carlos
   Zamorano, Jose
TI Influence of Lipoprotein (a) on Inflammatory Biomarkers in Metabolic
   Syndrome
SO SOUTHERN MEDICAL JOURNAL
LA English
DT Article
DE cytokines; inflammation; lipoprotein (a); metabolic syndrome; oxidative
   stress
ID ADIPOSE-TISSUE; ARTERY; RISK; ATHEROSCLEROSIS; ULTRASOUND; DISEASE
AB Objective: To examine the relation between plasma lipoprotein (a) (Lp[a]) levels and oxidative stress biomarkers, serum cytokines, and atherosclerotic burden among individuals recently diagnosed as having metabolic syndrome (MS).
   Methods: Eighty-four white patients with MS were classified according to two Lp(a) levels (normal Lp[a]: < 30 mg/dL or high Lp[a]: > 30mg/dL) and were compared with 42 healthy controls. Oxidative stress biomarkers (oxidized low-density lipoprotein, antibodies to oxidized low-density lipoprotein, and nitric oxide metabolites) and proinflammatory cytokines (interleukin [IL]-2, IL-4, IL-5, IL-6, IL-10, IL-12P70, IL-13, and interferon-gamma) were measured in plasma. Atherosclerotic significance was determined using carotid ultrasound and endothelial function by standardized protocols.
   Results: Patients with MS had higher levels of serum cytokines, oxidative stress markers, and C-reactive protein, and greater atherosclerosis burden as compared with controls. Among the group members, 58 patients had normal Lp(a) levels and 26 had high Lp(a) levels. Cytokines and C-reactive protein levels were significantly higher in patients with high Lp(a) compared with those with normal Lp(a) (P < 0.01 for IL-2 and P < 0.001 for the others). Nitric oxide metabolites were significantly lower in patients with high Lp(a) as compared with those with normal Lp(a) (P < 0.05). No differences were found in oxidized low-density lipoprotein and atherosclerotic burden between the two groups of patients with MS with respect to Lp(a) levels.
   Conclusions: Elevated Lp(a) plasma levels are associated with higher proinflammatory markers in patients newly diagnosed as having MS.
C1 Fdn Jimenez Diaz, E-28040 Madrid, Spain.
   Univ Extremadura, Caceres, Spain.
   Hosp San Pedro de Alcantara, Caceres, Spain.
C3 Universidad de Extremadura
RP Muñoz-Torrero, JFS (corresponding author), Avda Pablo Naranjo S-N, Caceres 10004, Spain.
EM Juanf.sanchezm@gmail.com
RI Alonso, Rodrigo/KHC-4268-2024; Muñoz-Torrer, Juan/AAE-9011-2021;
   Zamorano, Jose/Q-2514-2017
OI Sanchez Munoz-Torrero, Juan Francisco/0000-0003-0055-8875
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NR 21
TC 10
Z9 10
U1 0
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0038-4348
EI 1541-8243
J9 SOUTH MED J
JI South.Med.J.
PD JUL
PY 2012
VL 105
IS 7
BP 339
EP 343
DI 10.1097/SMJ.0b013e31825b5fb2
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 970FS
UT WOS:000306114100004
PM 22766659
DA 2025-06-11
ER

PT J
AU Chen, JL
   Chen, XL
   Lei, YF
   Wei, H
   Xiong, CM
   Liu, YJ
   Fu, W
   Ruan, JL
AF Chen, Jinglou
   Chen, Xiliu
   Lei, Yongfang
   Wei, Han
   Xiong, Chaomei
   Liu, Yujie
   Fu, Wei
   Ruan, Jinlan
TI Vascular protective potential of the total flavanol glycosides from
   Abacopteris penangiana via modulating nuclear transcription
   factor-κB signaling pathway and oxidative stress
SO JOURNAL OF ETHNOPHARMACOLOGY
LA English
DT Article
DE Abacopteris penangiana; Metabolic syndrome; Oxidative stress;
   Inflammatory state; Aortic pathology; Nuclear transcription factor-kappa
   B (NF kappa B)
ID INDUCED DIABETIC-RATS; HIGH-FAT DIET; LIPID-METABOLISM; MOUSE MODEL;
   ATHEROSCLEROSIS; NEPHROPATHY; CHOLESTEROL; EXPRESSION; PARAOXONASE-1;
   PATHOGENESIS
AB Ethnopharmacological relevance: "Sanxuelian", the rhizome of Abacopteris penangiana (AP), is traditionally used in Chinese medicine for the treatment of blood circulation stasis, hemorheology barriers, edema and inflammation for patients of metabolic syndrome. This study was to investigate the protective effect of the total flavanol glycosides from AP (FAP) on diabetic vascular impairments by measuring the extents of oxidative stress and inflammatory response in mice.
   Materials and methods: The experimental aortic pathology in diabetic mice was induced by fed on high-fat diet and injected with streptozotocin. The activities of FAP on attenuating aortas injuries, hypoglycemic, hypolipidemic, inhibiting oxidative stress and anti-inflammation were investigated. Additionally, the aortic expressions of nuclear transcription factor-kappa B (NF kappa B) were determined by western blot and immunohistochemistry analysis. Furthermore, the effects of FAP on human umbilical vein endothelia cells (HUVECs) were studied.
   Results: In animal study, the results showed that FAP enhanced the activities of antioxidant enzymes and attenuated the levels of proinflammatory cytokines. The plasma lipid profiles and glucose level in FM treated groups were significantly decreased along with the vascular impairments were alleviated. Moreover, the aortic expression of NF kappa B was decreased. In cellular experiment, FAP could inhibit the apoptosis of HUVECs induced by H2O2.
   Conclusions: The results indicated that FAP had hypolipidemic, hypoglycemic and vascular protective activities and represented a potential herb for the treatment of aortic pathology involved with metabolic syndrome. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
C1 [Chen, Jinglou; Lei, Yongfang; Wei, Han; Xiong, Chaomei; Liu, Yujie; Fu, Wei; Ruan, Jinlan] Huazhong Univ Sci & Technol, Tongji Med Coll, Coll Pharm, Key Lab Nat Med Chem & Resource Evaluat Hubei Pro, Wuhan 430030, Hubei Province, Peoples R China.
   [Chen, Xiliu] Huazhong Univ Sci & Technol, Tongji Med Coll, Union Hosp, Dept Infect Dis, Wuhan 430030, Hubei Province, Peoples R China.
C3 Huazhong University of Science & Technology; Huazhong University of
   Science & Technology
RP Ruan, JL (corresponding author), Huazhong Univ Sci & Technol, Tongji Med Coll, Coll Pharm, Key Lab Nat Med Chem & Resource Evaluat Hubei Pro, 13 Hangkong Rd, Wuhan 430030, Hubei Province, Peoples R China.
EM jinlan8152@163.com
RI Liu, Yu-Jie/JTS-3401-2023; Wei, Han/M-2536-2015
FU State Natural Sciences Fund [NO30973864]; Ministry of Education
   [NO20090142110021]; Key Natural Science Fund of Hubei Province
   [NO2009CDA067]
FX The authors thank Prof. Ceming Tan from the Jiujiang Forest Plants
   Specimen Mansion for the identification of the plant, the financial
   support from State Natural Sciences Fund (NO30973864), Ministry of
   Education Fund for doctoral program of higher subjects
   (NO20090142110021) and Key Natural Science Fund of Hubei Province
   (NO2009CDA067).
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NR 36
TC 21
Z9 23
U1 0
U2 15
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0378-8741
J9 J ETHNOPHARMACOL
JI J. Ethnopharmacol.
PD JUN 14
PY 2011
VL 136
IS 1
BP 217
EP 223
DI 10.1016/j.jep.2011.04.052
PG 7
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA 792CF
UT WOS:000292717400026
PM 21549824
DA 2025-06-11
ER

PT J
AU Nabeshima, A
   Yamada, S
   Guo, X
   Tanimoto, A
   Wang, KY
   Shimajiri, S
   Kimura, S
   Tasaki, T
   Noguchi, H
   Kitada, S
   Watanabe, T
   Fujii, J
   Kohno, K
   Sasaguri, Y
AF Nabeshima, Atsunori
   Yamada, Sohsuke
   Guo, Xin
   Tanimoto, Akihide
   Wang, Ke-Yong
   Shimajiri, Shohei
   Kimura, Satoshi
   Tasaki, Takashi
   Noguchi, Hirotsugu
   Kitada, Shohei
   Watanabe, Teruo
   Fujii, Junichi
   Kohno, Kimitoshi
   Sasaguri, Yasuyuki
TI Peroxiredoxin 4 Protects Against Nonalcoholic Steatohepatitis and Type 2
   Diabetes in a Nongenetic Mouse Model
SO ANTIOXIDANTS & REDOX SIGNALING
LA English
DT Article
ID FATTY LIVER-DISEASE; HIGH-FRUCTOSE DIET; INSULIN-RESISTANCE;
   OVEREXPRESSION; GLUCOSE; STRESS; RATS; MICE
AB Aims: Consumption of a high-fructose diet (HFrD) can induce the development of a metabolic syndrome, manifesting as nonalcoholic steatohepatitis (NASH) and/or type 2 diabetes mellitus (T2DM), via a process in which oxidative stress plays a critical role. Peroxiredoxin 4 (PRDX4) is a unique and only known secretory member of the PRDX antioxidant family. However, its putative roles in the development of NASH and/or T2DM have not been investigated. Results: To elucidate the functions of PRDX4 in a metabolic syndrome, we established a nongenetic mouse model of T2DM by feeding mice a HFrD after injecting a relatively low dose of streptozotocin. Compared with wild-type (WT), human PRDX4 transgenic (Tg) mice exhibited significant improvements in insulin resistance, characterized by a lower glucose and insulin concentration and faster responses in glucose tolerance tests. The liver of Tg also showed less severe vesicular steatosis, inflammation, and fibrosis, along with lower lipid concentrations, lower levels of oxidative stress markers, more decreased expression of hepatic aminotransferase, and more reduced stellate cell activation than those in the WT liver, reminiscent of human early NASH. Hepatocyte apoptosis was also significantly repressed in Tg mice. By contrast, serum adiponectin levels and hepatic adiponectin receptor expression were significantly lower in WT mice, consistent with greater insulin resistance in the peripheral liver tissue compared with Tg mice. Innovation and Conclusion: Our data for the first time show that PRDX4 may protect against NASH, T2DM, and the metabolic syndrome by ameliorating oxidative stress-induced injury. Antioxid. Redox Signal. 19, 1983-1998.
C1 [Nabeshima, Atsunori; Yamada, Sohsuke; Guo, Xin; Tanimoto, Akihide; Wang, Ke-Yong; Shimajiri, Shohei; Kimura, Satoshi; Tasaki, Takashi; Noguchi, Hirotsugu; Kitada, Shohei; Sasaguri, Yasuyuki] Univ Occupat & Environm Hlth, Sch Med, Dept Pathol & Cell Biol, Kitakyushu, Fukuoka 8078555, Japan.
   [Tanimoto, Akihide] Kagoshima Univ, Grad Sch Med & Dent Sci, Field Oncol, Dept Tumor Pathol, Kagoshima 890, Japan.
   [Kitada, Shohei] Univ Occupat & Environm Hlth, Sch Med, Dept Urol, Kitakyushu, Fukuoka 8078555, Japan.
   [Watanabe, Teruo] Fukuoka Wajiro Hosp, Pathol Lab, Fukuoka, Japan.
   [Fujii, Junichi] Yamagata Univ, Grad Sch Med Sci, Dept Biomol Funct, Yamagata 990, Japan.
   [Kohno, Kimitoshi] Univ Occupat & Environm Hlth, Sch Med, Dept Mol Biol, Kitakyushu, Fukuoka 8078555, Japan.
C3 University of Occupational & Environmental Health - Japan; Kagoshima
   University; University of Occupational & Environmental Health - Japan;
   Yamagata University; University of Occupational & Environmental Health -
   Japan
RP Yamada, S (corresponding author), Univ Occupat & Environm Hlth, Sch Med, Dept Pathol & Cell Biol, Yahatanishi Ku, Kitakyushu, Fukuoka 8078555, Japan.
EM sousuke@med.uoeh-u.ac.jp
OI Fujii, Junichi/0000-0003-2267-7357; wang, ke-yong/0000-0001-8295-1229
FU Ministry of Education, Culture, Sports, Science, and Technology, Tokyo,
   Japan [24790394, 20590416, 19590413]; Grants-in-Aid for Scientific
   Research [19590413, 20590416, 24790394] Funding Source: KAKEN
FX We would like to thank Hiroko Isagai, Hana Nishimura, and Naoko Une for
   their expert technical assistance; we thank Masaru Harada, Mitsuyoshi
   Yamamoto, and Masashi Taguchi (Third Department of Internal Medicine,
   University of Occupational and Environmental Health, School of
   Medicine), and Shinji Matsumoto, for collecting and preparing from
   peripheral blood cells of patients with T2DM; and we also thank Sachiko
   Iwai (Information, Production and Systems Research Center, Waseda
   University) for her expert assistance with statistical analysis. This
   work was supported, in part, by Grants-in-Aid for Scientific Research
   (24790394, 20590416, and 19590413) from the Ministry of Education,
   Culture, Sports, Science, and Technology, Tokyo, Japan (to S.Y., Y.S.,
   K.K., and A.T.).
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NR 31
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U2 13
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1523-0864
EI 1557-7716
J9 ANTIOXID REDOX SIGN
JI Antioxid. Redox Signal.
PD DEC 10
PY 2013
VL 19
IS 17
BP 1983
EP 1998
DI 10.1089/ars.2012.4946
PG 16
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 273SQ
UT WOS:000328557000001
PM 23477499
OA Green Accepted, Green Published
DA 2025-06-11
ER

PT J
AU Livadas, S
   Dracopoulou, M
   Vasileiadi, K
   Lazaropoulou, C
   Magiakou, MA
   Xekouki, P
   Voutetakis, A
   Kanaka-Gantenbein, C
   Papassotiriou, I
   Stefanadis, C
   Chrousos, GP
   Dacou-Voutetakis, C
AF Livadas, Sarantis
   Dracopoulou, Maria
   Vasileiadi, Karmen
   Lazaropoulou, Christina
   Magiakou, Maria-Alexandra
   Xekouki, Paraskevi
   Voutetakis, Antonis
   Kanaka-Gantenbein, Christina
   Papassotiriou, Ioannis
   Stefanadis, Christodoulos
   Chrousos, George P.
   Dacou-Voutetakis, Catherine
TI Elevated coagulation and inflammatory markers in adolescents with a
   history of premature adrenarche
SO METABOLISM-CLINICAL AND EXPERIMENTAL
LA English
DT Article
ID POLYCYSTIC-OVARY-SYNDROME; PLASMINOGEN-ACTIVATOR INHIBITOR-1;
   CARDIOVASCULAR RISK-FACTORS; GRADE CHRONIC INFLAMMATION;
   FLUTAMIDE-METFORMIN PLUS; OXIDATIVE STRESS MARKERS; C-REACTIVE PROTEIN;
   INSULIN-RESISTANCE; YOUNG-WOMEN; ENDOTHELIAL DYSFUNCTION
AB Females with a history of premature adrenarche are at high risk of developing polycystic ovary syndrome (PCOS) and features of the metabolic syndrome later in life. Coagulation disorders, subclinical inflammation, and oxidative stress have been reported in patients with PCOS and metabolic syndrome. These factors were studied in a group of adolescents with a history of premature adrenarche. This is a cross-sectional study that determined the biochemical-hormonal profile and indices of inflammation, coagulation, and oxidative stress in 45 adolescent girls with a history of premature adrenarche and 19 age- and body mass index-matched controls. Girls with premature adrenarche had hyperandrogenism and higher indices of insulin resistance than controls. They also had significantly higher C-reactive protein (0.76 +/- 0.65 vs 0.41 +/- 0.31 mg/L, P =.0001) and plasminogen activator inhibitor 1 (37.6 +/- 24.7 vs 24.47 +/- 4.6 ng/mL, P = .034), and lower tissue plasminogen activator values in comparison with controls (3.5 +/- 1.5 vs 5.2 +/- 2.12 ng/mL, P = .0019). Both C-reactive protein(r = 0.545, P =.0001) and plasminogen activator inhibitor I (r = 0.36, P =.04) were positively correlated with oxidative stress, whereas tissue plasminogen activator was positively correlated (r = 0.37, P.02) with total antioxidant status. None of these factors was correlated with androgens or indices of insulin resistance. Adolescent girls with a history of premature adrenarche display metabolic deviations usually encountered in Subjects with PCOS and metabolic syndrome, such as subclinical inflammation and fibrinolytic abnormalities. Crown Copyright (C) 2009 Published by Elsevier Inc. All rights reserved.
C1 [Livadas, Sarantis; Dracopoulou, Maria; Magiakou, Maria-Alexandra; Xekouki, Paraskevi; Voutetakis, Antonis; Kanaka-Gantenbein, Christina; Chrousos, George P.; Dacou-Voutetakis, Catherine] Univ Athens, Sch Med, Aghia Sophia Childrens Hosp, Dept Pediat 1, GR-11527 Athens, Greece.
   [Vasileiadi, Karmen; Stefanadis, Christodoulos] Univ Athens, Sch Med, Hippokrat Hosp, Dept Cardiol 1, GR-11527 Athens, Greece.
   [Lazaropoulou, Christina; Papassotiriou, Ioannis] Aghia Sophia Childrens Hosp, Dept Clin Biochem, Athens 11527, Greece.
C3 National & Kapodistrian University of Athens; The Aghia Sophia
   Children's Hospital; Athens Medical School; Athens Medical School;
   National & Kapodistrian University of Athens; Hippokration General
   Hospital; The Aghia Sophia Children's Hospital
EM srntis@hotmail.com
RI Kanaka-Gantenbein, Christina/AAP-3697-2020; Chrousos,
   George/G-8702-2011; Livadas, Sarantis/D-2668-2014; Xekouki,
   Paraskevi/AAM-2485-2021; Stefanadis, Christodoulos/ABH-2232-2020
OI Livadas, Sarantis/0000-0001-9594-1521; Xekouki,
   Paraskevi/0000-0001-5205-747X; Stefanadis,
   Christodoulos/0000-0001-5974-6454
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NR 47
TC 18
Z9 21
U1 0
U2 0
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0026-0495
EI 1532-8600
J9 METABOLISM
JI Metab.-Clin. Exp.
PD APR
PY 2009
VL 58
IS 4
BP 576
EP 581
DI 10.1016/j.metabol.2008.12.002
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 429QV
UT WOS:000264936100022
PM 19303981
DA 2025-06-11
ER

PT J
AU Bekkouche, L
   Bouchenak, M
   Malaisse, WJ
   Yahia, DA
AF Bekkouche, L.
   Bouchenak, M.
   Malaisse, W. J.
   Yahia, D. Ait
TI The Mediterranean Diet Adoption Improves Metabolic, Oxidative, and
   Inflammatory Abnormalities in Algerian Metabolic Syndrome Patients
SO HORMONE AND METABOLIC RESEARCH
LA English
DT Article
DE metabolic syndrome; mediterranean diet; human; inflammation; oxidative
   stress; nutrient intake
ID MYOCARDIAL-INFARCTION; INSULIN SENSITIVITY; ABDOMINAL OBESITY;
   WEIGHT-LOSS; STYLE DIET; ADHERENCE; RISK; PREVALENCE; PROTEIN; STRESS
AB This study was aimed to explore the effects of Mediterranean diet (MD) adoption on insulin resistance, oxidative, and inflammatory status in metabolic syndrome (MS) patients. Eighty four patients with MS were randomly recruited in the medical centers of Oran, Algeria. Eighteen healthy participants were selected as a control group. Among these 84 patients, only 36 patients completed the nutritional advices for 3 months. Patients were instructed to follow a Mediterranean-style diet and received some other selected nutritional and physical activity instructions. Anthropometric measurements were performed and a questionnaire was used to assess dietary intake. Blood samples were drawn at baseline and after 3 months of nutritional intervention from all subjects. At baseline, the MS patients were obese and had altered anthropometric parameters, higher systolic and diastolic blood pressure, plasma lipids, glucose, insulin, HOMA-IR, HbA1c, urea, creatinine, uric acid, and lower albumin compared to healthy subjects. A decrease in plasma, erythrocyte, and platelet antioxidant enzymes, and a rise in lipid and protein oxidation, plasma CRP, and fibrinogen were noted in the MS patients. Moreover, they had an unbalanced dietary pattern when compared to Mediterranean recommendations. Patients following the Mediterranean-style diet had significantly reduced weight, BMI, waist circumference, waist/hip circumference ratio, decreased systolic and diastolic blood pressure, plasma glucose, insulin, HOMA-IR, HbA1c, cholesterol, triacylglycerols, CRP, urea, creatinine, creatinine clearance, lipid and protein oxidation, and higher plasma, erythrocyte, and platelet antioxidant enzymes. In conclusion, a lifestyle intervention based mainly on nutritional advices improves metabolic, oxidative, and inflammatory abnormalities of metabolic syndrome.
C1 [Bekkouche, L.; Bouchenak, M.] Univ Oran, Fac Sci Nat & Vie, Lab Nutr Clin & Metab, Oran, Algeria.
   [Malaisse, W. J.] Univ Libre Bruxelles, Lab Expt Hormonol, B-1070 Brussels, Belgium.
   [Yahia, D. Ait] Univ Oran, Fac Sci Nat & Vie, Dept Biol, Oran, Algeria.
C3 Universite d'Oran; Universite Libre de Bruxelles; Universite d'Oran
RP Malaisse, WJ (corresponding author), Univ Libre Bruxelles, Lab Expt Hormonol, Route Lennik 808, B-1070 Brussels, Belgium.
EM malaisse@ulb.ac.be
RI Bouchenak, Malika/C-6739-2015
OI Bouchenak, Malika/0000-0001-8713-3452
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NR 56
TC 28
Z9 29
U1 1
U2 12
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0018-5043
EI 1439-4286
J9 HORM METAB RES
JI Horm. Metab. Res.
PD APR
PY 2014
VL 46
IS 4
BP 274
EP 282
DI 10.1055/s-0033-1363657
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA AJ4WF
UT WOS:000337678800007
PM 24446153
DA 2025-06-11
ER

PT J
AU Timofte, D
   Ochiuz, L
   Ursaru, M
   Ciuntu, B
   Ionescu, L
   Calu, V
   Mocanu, V
   Puia, IC
AF Timofte, Daniel
   Ochiuz, Lacramioara
   Ursaru, Manuela
   Ciuntu, Bogdan
   Ionescu, Lidia
   Calu, Valentin
   Mocanu, Veronica
   Puia, Ion Cosmin
TI Biochemical Modifications Related to Calcium Deficiencies in Obesity and
   After Laparoscopic Sleeve Gastrectomy
SO REVISTA DE CHIMIE
LA English
DT Article
DE calcium; serum; laparoscopic; gastrectomy
ID METABOLIC BONE-DISEASE; INSULIN-RESISTANCE SYNDROME; OXIDATIVE STRESS
   STATUS; GASTRIC BYPASS-SURGERY; VITAMIN-D METABOLITES; BODY-FAT
   DISTRIBUTION; MORBID-OBESITY; JEJUNOILEAL BYPASS; WEIGHT-LOSS; SECONDARY
   HYPERPARATHYROIDISM
AB Lately there is some discussion about an inverse relationship exists between calcium intake and obesity markers such as body weight, weight gain or body fat percentage. However, numerous studies question the idea whether adequate calcium nutrition can prevent or even reduce obesity. However, the disagreement from many studies seems to have more to do with the interpretation of the data than the data itself, with different hypothesis which could be valid in different specific populations. Still, the major finding we present here are in line with previous research demonstrating that lower levels of serum calcium are common after bariatric surgeries.
C1 [Timofte, Daniel; Ursaru, Manuela; Ionescu, Lidia] Grigore T Popa Univ Med & Pharm, Dept Gen Surg, 16 Univ Str, Iasi 700115, Romania.
   [Ochiuz, Lacramioara] Grigore T Popa Univ Med & Pharm, Dept Pharmaceut & Biotechnol Drug Ind, 16 Univ Str, Iasi 700115, Romania.
   [Ciuntu, Bogdan] Grigore T Popa Univ Med & Pharm, Dept Radiol, 16 Univ Str, Iasi 700115, Romania.
   [Calu, Valentin] Carol Davila Univ Med & Pharm, Elias Emergency Univ Hosp, Dept Gen Surg, 37 Dionisie Lupu Str, Bucharest 030167, Romania.
   [Mocanu, Veronica] Grigore T Popa Univ Med & Pharm, Dept Pathophysiol, 16 Univ Str, Iasi 700115, Romania.
   [Puia, Ion Cosmin] Iuliu Hateganu Univ Med & Pharm, 8 Victor Babes Str, Cluj Napoca 400000, Romania.
   [Puia, Ion Cosmin] Octavian Fodor Reg Inst Gastroenterol & Hepatol C, 19 Croitorilor Str, Cluj Napoca 400000, Romania.
C3 Grigore T Popa University of Medicine & Pharmacy; Grigore T Popa
   University of Medicine & Pharmacy; Grigore T Popa University of Medicine
   & Pharmacy; Carol Davila University of Medicine & Pharmacy; Grigore T
   Popa University of Medicine & Pharmacy; Iuliu Hatieganu University of
   Medicine & Pharmacy; Regional Institute of Gastroenterology & Hepatology
RP Ochiuz, L (corresponding author), Grigore T Popa Univ Med & Pharm, Dept Pharmaceut & Biotechnol Drug Ind, 16 Univ Str, Iasi 700115, Romania.
EM ochiuzd@yahoo.com
RI Ciuntu, Bogdan/MTF-9477-2025; Ochiuz, Lacramioara/ACM-6961-2022; Mocanu,
   Veronica/AAQ-6285-2020; Puia, Ion Cosmin/AAA-4949-2022; Timofte,
   Daniel/AAE-2511-2019; CALU, VALENTIN/AAN-8374-2020
OI Timofte, Daniel/0000-0002-6604-874X; CALU, VALENTIN/0000-0001-7710-9109;
   Mocanu, Veronica/0000-0002-9330-1691
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NR 85
TC 7
Z9 7
U1 1
U2 8
PU CHIMINFORM DATA S A
PI BUCHAREST
PA CALEA PLEVNEI NR 139, SECTOR 6, BUCHAREST R-77131, ROMANIA
SN 0034-7752
J9 REV CHIM-BUCHAREST
JI Rev. Chim.
PD OCT
PY 2017
VL 68
IS 10
BP 2341
EP 2345
PG 5
WC Chemistry, Multidisciplinary; Engineering, Chemical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Engineering
GA FO3RK
UT WOS:000416750000027
DA 2025-06-11
ER

PT J
AU Sener, TE
   Çevik, O
   Çetinel, S
   Sener, G
AF Sener, Tarik Emre
   Cevik, Ozge
   Cetinel, Sule
   Sener, Goksel
TI Oxidative stress and urinary system damage in fructose-induced rat model
   of metabolic syndrome: Effect of calorie restriction and exercise
SO JOURNAL OF RESEARCH IN PHARMACY
LA English
DT Article
DE Metabolic syndrome; exercise; calorie restriction; kidney; bladder
ID RISK
AB The aim of this study was to investigate the effects of calorie restriction (CR) and swimming exercise (SW) on oxidative injury in kidney and bladder tissues, in rats with metabolic syndrome (MS). 3-months old rats were divided into five; Control, MS, MS+CR, MS+SW, MS+CR+SW. The metabolic syndrome model was created using 10% fructose solution in drinking water for three months. Afterwards, SW and 40% CR were applied for six weeks. Blood glucose measurements were performed at the beginning, the third month and the end of experiment. After decapitation, blood, kidney and bladder samples were collected. Cytokine levels, antioxidant and oxidative stress parameters were examined. There was a remarkable change in blood glucose levels in MS+CR+SW group. Fructose-induced increased TNF-alpha and decreased ADP levels in plasma were reversed in CR, SW, and CR+SW groups. MDA levels were increased, while SOD and ADP levels were decreased in renal and bladder tissues in MS group. CR and SW significantly reversed all parameters in both tissues. Moreover, caspase activity increased in both tissues in MS group. CR decreased the caspase activity in kidney tissue, and in bladder tissues caspase activity significantly decreased with both CR and SW. Western blot analysis showed an increased caspase-3 protein expression in both tissues which was reversed by CR, SW, and CR+SW. The results of our study showed that MS disrupts the balance of pro/anti-inflammatory cytokines in plasma and causes oxidant damage in urinary tissues. Calorie restriction and exercise are protective against the damage caused by MS.
C1 [Sener, Tarik Emre] Marmara Univ Hosp, Dept Urol, Istanbul, Turkey.
   [Cevik, Ozge] Cumhuriyet Univ, Fac Pharm, Dept Biochem, Sivas, Turkey.
   [Cetinel, Sule] Marmara Univ, Sch Med, Dept Histol, Istanbul, Turkey.
   [Sener, Goksel] Marmara Univ, Sch Pharm, Dept Pharmacol, Istanbul, Turkey.
C3 Marmara University; Cumhuriyet University; Marmara University; Marmara
   University
RP Sener, G (corresponding author), Marmara Univ, Sch Pharm, Dept Pharmacol, Istanbul, Turkey.
EM gsener@marmara.edu.tr
RI University, Aydin Adnan/Z-2790-2019; Sener, Tarik/K-2501-2016; cetinel,
   sule/AAB-8510-2022; Şener, Göksel/AAN-4461-2021
OI CETINEL, SULE/0000-0003-1912-3679; Sener, Goksel/0000-0001-7444-6193
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NR 18
TC 3
Z9 3
U1 0
U2 2
PU MARMARA UNIV
PI ISTANBUL
PA GOZTEPE CAMPUS, KADIKOY, ISTANBUL, 34722, TURKEY
SN 2630-6344
J9 J RES PHARM
JI J. Res. Pharm.
PY 2020
VL 24
IS 3
BP 318
EP 325
DI 10.35333/jrp.2020.153
PG 8
WC Pharmacology & Pharmacy
WE Emerging Sources Citation Index (ESCI)
SC Pharmacology & Pharmacy
GA LS9YO
UT WOS:000536734800002
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Calligaris, SD
   Lecanda, M
   Solis, F
   Ezquer, M
   Gutiérrez, J
   Brandan, E
   Leiva, A
   Sobrevia, L
   Conget, P
AF Calligaris, Sebastian D.
   Lecanda, Manuel
   Solis, Felipe
   Ezquer, Marcelo
   Gutierrez, Jaime
   Brandan, Enrique
   Leiva, Andrea
   Sobrevia, Luis
   Conget, Paulette
TI Mice Long-Term High-Fat Diet Feeding Recapitulates Human Cardiovascular
   Alterations: An Animal Model to Study the Early Phases of Diabetic
   Cardiomyopathy
SO PLOS ONE
LA English
DT Article
ID METABOLIC SYNDROME; INSULIN-RESISTANCE; C57BL/6 MICE;
   GLUCOSE-INTOLERANCE; INDUCED OBESITY; RISK-FACTORS; EXPRESSION; HEART;
   DISEASE; STRESS
AB Background/Aim: Hypercaloric diet ingestion and sedentary lifestyle result in obesity. Metabolic syndrome is a cluster clinical features secondary to obesity, considered as a pre-diabetic condition and recognized as an independent risk factor for cardiovascular diseases. To better understand the relationship between obesity, metabolic syndrome and cardiovascular disease as well as for the development of novel therapeutic strategies, animal models that reproduce the etiology, course and outcomes of these pathologies are required. The aim of this work was to characterize the long-term effects of high-fat diet-induced obesity on the mice cardiovascular system, in order to make available a new animal model for diabetic cardiomyopathy.
   Methods/Results: Male C57BL/6 mice were fed with a standardized high-fat diet (obese) or regular diet (normal) for 16 months. Metabolic syndrome was evaluated testing plasma glucose, triglycerides, cholesterol, insulin, and glucose tolerance. Arterial pressure was measured using a sphygmomanometer (non invasive method) and by hemodynamic parameters (invasive method). Cardiac anatomy was described based on echocardiography and histological studies. Cardiac function was assessed by cardiac catheterization under a stress test. Cardiac remodelling and metabolic biomarkers were assessed by RT-qPCR and immunoblotting. As of month eight, the obese mice were overweight, hyperglycaemic, insulin resistant, hyperinsulinemic and hypercholesterolemic. At month 16, they also presented normal arterial pressure but altered vascular reactivity (vasoconstriction), and cardiac contractility reserve reduction, heart mass increase, cardiomyocyte hypertrophy, cardiac fibrosis, and heart metabolic compensations. By contrast, the normal mice remained healthy throughout the study.
   Conclusions: Mice fed with a high-fat diet for prolonged time recapitulates the etiology, course and outcomes of the early phases of human diabetic cardiomyopathy.
C1 [Calligaris, Sebastian D.; Lecanda, Manuel; Solis, Felipe; Ezquer, Marcelo; Conget, Paulette] Univ Desarrollo, Fac Med, Clin Alemana, Inst Ciencias, Santiago, Chile.
   [Gutierrez, Jaime; Brandan, Enrique] Pontificia Univ Catolica Chile, MIFAB, Ctr Regulac Celular & Patol, Dept Biol Celular & Mol, Santiago, Chile.
   [Leiva, Andrea; Sobrevia, Luis] Pontificia Univ Catolica Chile, Sch Med, Fac Med, Div Obstet & Gynecol,CMPL, Santiago, Chile.
   [Sobrevia, Luis] Univ Queensland, Clin Res Ctr, Herston, Qld, Australia.
C3 Clinica Alemana; Universidad del Desarrollo; Pontificia Universidad
   Catolica de Chile; Pontificia Universidad Catolica de Chile; University
   of Queensland
RP Calligaris, SD (corresponding author), Univ Desarrollo, Fac Med, Clin Alemana, Inst Ciencias, Santiago, Chile.
EM scalligaris@udd.cl
RI Sobrevia, Luis/H-9608-2016; Brandan, Enrique/A-7063-2017
OI Ezquer, Marcelo/0000-0002-2064-3041; Calligaris Caprioglio, Sebastian
   Dante/0000-0002-9296-6739; Leiva Mendoza, Andrea/0000-0001-7349-5380;
   Brandan, Enrique/0000-0002-6820-5059; Sobrevia,
   Luis/0000-0001-5802-2243; Conget, Paulette/0000-0002-2530-7936
FU FONDECYT (Fondo Nacional de Desarrollo Cientifico y Tecnologico)
   [11090114]
FX This work was supported by FONDECYT (Fondo Nacional de Desarrollo
   Cientifico y Tecnologico) grant No 11090114 to S.D.C. The funders had no
   role in study design, data collection and analysis, decision to publish,
   or preparation of the manuscript.
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NR 58
TC 124
Z9 135
U1 2
U2 28
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD APR 11
PY 2013
VL 8
IS 4
AR e60931
DI 10.1371/journal.pone.0060931
PG 10
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 123JA
UT WOS:000317383200029
PM 23593350
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Dipasquale, S
   Pariante, CM
   Dazzan, P
   Aguglia, E
   McGuire, P
   Mondelli, V
AF Dipasquale, Salvatore
   Pariante, Carmine M.
   Dazzan, Paola
   Aguglia, Eugenio
   McGuire, Philip
   Mondelli, Valeria
TI The dietary pattern of patients with schizophrenia: A systematic review
SO JOURNAL OF PSYCHIATRIC RESEARCH
LA English
DT Review
DE Diet; Psychosis; Metabolic syndrome; Cardiovascular Lifestyle; Stress
ID DRUG-NAIVE PATIENTS; CORTISOL AWAKENING RESPONSE; COMMUNITY-DWELLING
   PATIENTS; LIFE-STYLE; METABOLIC SYNDROME; CARDIOVASCULAR RISK;
   1ST-EPISODE PSYCHOSIS; GLUCOSE-TOLERANCE; ATYPICAL ANTIPSYCHOTICS;
   PHYSICAL-ACTIVITY
AB Objective: People with schizophrenia show a high incidence of metabolic syndrome, which is associated with a high mortality from cardiovascular disease. The aetiology of the metabolic syndrome in schizophrenia is multi-factorial and may involve antipsychotic treatment, high levels of stress and unhealthy lifestyle, such as poor diet. As a poor diet can predispose to the development of metabolic abnormalities, the aims of this review are to clarify: 1) the dietary patterns of patients with schizophrenia, 2) the association of these dietary patterns with a worse metabolic profile, and 3) the possible factors influencing these dietary patterns.
   Methods: A search was conducted on Pubmed, The Cochrane Library, Scopus, Embase, Ovid, Psychoinfo and ISI web of Knowledge from 1950 to the 1st of November 2011. 783 articles were found through the investigation of such databases. After title, abstract or full-text reading and applying exclusion criteria we reviewed 31 studies on dietary patterns and their effects on metabolic parameters in schizophrenia.
   Results: Patients with schizophrenia have a poor diet, mainly characterized by a high intake of saturated fat and a low consumption of fibre and fruit. Such diet is more likely to increase the risk to develop metabolic abnormalities. Data about possible causes of poor diet in schizophrenia are still few and inconsistent.
   Conclusion: Subjects with schizophrenia show a poor diet that partly accounts for their higher incidence of metabolic abnormalities. Further studies are needed to clarify the causes of poor diet and the role of dietary intervention to improve their physical health. (C) 2012 Elsevier Ltd. All rights reserved.
C1 [Dipasquale, Salvatore; Pariante, Carmine M.; Mondelli, Valeria] Kings Coll London, Inst Psychiat, Dept Psychol Med, London SE5 9NU, England.
   [Dazzan, Paola; McGuire, Philip] Kings Coll London, Inst Psychiat, Dept Psychosis Studies, London SE5 9NU, England.
   [Dipasquale, Salvatore; Aguglia, Eugenio] Univ Catania, UOPI Psichiatria, AOU Policlin Vittorio Emanuele, Catania, Italy.
C3 University of London; King's College London; University of London;
   King's College London; Azienda Ospedaliera Universitaria Policlinico
   Vittorio Emanuele Presidio Ferraotto; University of Catania
RP Mondelli, V (corresponding author), Kings Coll London, Sect Perinatal Psychiat & Stress, Ctr Cellular Basis Behav, James Black Ctr,Inst Psychiat, 125 Coldharbour Lane, London SE5 9NU, England.
EM valeria.mondelli@kcl.ac.uk
RI Dazzan, Paola/E-6837-2010; McGuire, Philip/AFJ-9527-2022; Mondelli,
   Valeria/K-8988-2016; Pariante, Carmine Maria/B-1297-2011
OI aguglia, eugenio/0000-0003-2146-7737; McGuire,
   Philip/0000-0003-4381-0532; Dazzan, Paola/0000-0002-8427-3617; Mondelli,
   Valeria/0000-0001-8690-6839; Pariante, Carmine Maria/0000-0002-9132-5091
FU South London and Maudsley NHS Foundation Trust & Institute of Psychiatry
   NIHR Biomedical Research Centre for Mental Health; Academy of Medical
   Sciences; Wellcome Trust; British Heart Foundation; European College of
   Neuropsychopharmacology Research Grant; MRC [G108/603] Funding Source:
   UKRI
FX This research has been supported by the South London and Maudsley NHS
   Foundation Trust & Institute of Psychiatry NIHR Biomedical Research
   Centre for Mental Health; a Starter Grant for Clinical Lecturers from
   the Academy of Medical Sciences, the Wellcome Trust and the British
   Heart Foundation, and a s2 for Young Scientists to V. Mondelli.
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NR 81
TC 289
Z9 312
U1 2
U2 67
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-3956
EI 1879-1379
J9 J PSYCHIATR RES
JI J. Psychiatr. Res.
PD FEB
PY 2013
VL 47
IS 2
BP 197
EP 207
DI 10.1016/j.jpsychires.2012.10.005
PG 11
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 081NY
UT WOS:000314330100009
PM 23153955
OA Green Submitted, hybrid
DA 2025-06-11
ER

PT J
AU Madkor, HR
   Mansour, SW
   Ramadan, G
AF Madkor, Hafez R.
   Mansour, Sherif W.
   Ramadan, Gamal
TI Modulatory effects of garlic, ginger, turmeric and their mixture on
   hyperglycaemia, dyslipidaemia and oxidative stress in
   streptozotocin-nicotinamide diabetic rats
SO BRITISH JOURNAL OF NUTRITION
LA English
DT Article
DE Albino rats; Antioxidant activity; Complementary/alternative medicine;
   Metabolic syndrome; Streptozotocin-nicotinamide diabetes
ID DENSITY LIPOPROTEIN CHOLESTEROL; ZINGIBER-OFFICINALE ROSCOE; CURCUMIN;
   EXTRACT; MICE; TETRAHYDROCURCUMIN; ATHEROSCLEROSIS; ENZYMES; PLASMA;
   LIPIDS
AB Spices which show hypoglycaemic, hypolipidaemic and antioxidant activities may have a role in the treatment of diabetes and its complications. The present study aimed to compare the modulatory effects of garlic, ginger, turmeric and their mixture on the metabolic syndrome and oxidative stress in streptozotocin (STZ)-nicotinamide diabetic rats. Diabetes was induced in overnight fasted rats by a single intraperitoneal injection of STZ (65 mg/kg body weight) and nicotinamide (110 mg/kg body weight, 15 min before STZ injection). Diabetic rats orally received either distilled water (as vehicle) or 200 mg/kg body weight of garlic bulb, ginger rhizome or turmeric rhizome powder suspension separately or mixed together (GGT mixture) for twenty-eight consecutive days. The results showed that these spices and their mixture significantly alleviated (80-97%, P<0.05-0.001) signs of the metabolic syndrome (hyperglycaemia and dyslipidaemia), the elevation in atherogenic indices and cellular toxicity in STZ-nicotinamide diabetic rats by increasing the production of insulin (26-37%), enhancing the antioxidant defence system (31-52%, especially GSH) and decreasing lipid peroxidation (60-97%). The greatest modulation was seen in diabetic rats that received garlic and the GGT mixture (10-23% more than that in the ginger and turmeric groups). In conclusion, garlic or the mix including garlic appears to have an impact on each of the measures more effectively than ginger and turmeric and may have a role in alleviating the risks of the metabolic syndrome and cardiovascular complications.
C1 [Ramadan, Gamal] King Faisal Univ, Coll Sci, Dept Biol Sci, Al Hufof, KSA, Saudi Arabia.
   [Ramadan, Gamal] Ain Shams Univ, Fac Sci, Dept Zool, Cairo 11566, Egypt.
   [Madkor, Hafez R.; Mansour, Sherif W.] King Faisal Univ, Coll Clin Pharm, Dept Biomed Sci, Al Hufof, KSA, Saudi Arabia.
C3 King Faisal University; Egyptian Knowledge Bank (EKB); Ain Shams
   University; King Faisal University
RP Ramadan, G (corresponding author), King Faisal Univ, Coll Sci, Dept Biol Sci, Al Hufof, KSA, Saudi Arabia.
EM gamal_ramadan@hotmail.com
RI Dr. Sherif Wagih Mansour, Head of Quality/T-5660-2019; Madkor,
   Hafez/AAW-9996-2020; Ramadan, Gamal/A-8666-2012
OI Mansour, Sherif/0000-0002-6443-265X; Ramadan, Gamal/0000-0002-3357-0216
FU King Faisal University [10033]
FX The present study was supported by the Deanship of Scientific Research,
   King Faisal University (10033 to H. R. M.). The authors thank Mr Tameen
   M. Al-Yahian, our laboratory technician, for animal care. S. W. M. and
   G. R. planned the study and designed the experiments. H. R. M. and S. W.
   M., with assistance from G. R., carried out all experiments. G. R.
   performed the statistical analysis and summarised the results, and
   drafted the manuscript with assistance from S. W. M. and H. R. M. The
   authors have no potential financial conflict of interest.
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U1 0
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PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1145
EI 1475-2662
J9 BRIT J NUTR
JI Br. J. Nutr.
PD APR
PY 2011
VL 105
IS 8
BP 1210
EP 1217
DI 10.1017/S0007114510004927
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 739VS
UT WOS:000288748700011
PM 21144104
OA Bronze
DA 2025-06-11
ER

PT J
AU Liang, YC
   Kaushal, D
   Wilson, RB
AF Liang, Yicong
   Kaushal, Devesh
   Wilson, Robert Beaumont
TI Cellular Senescence and Extracellular Vesicles in the Pathogenesis and
   Treatment of Obesity-A Narrative Review
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE adiponectin; aging; AMPK; autophagy; cellular senescence; DDR; ER
   stress; epigenome; exosomes; extracellular vesicles; hypertrophic
   obesity; insulin resistance; lipotoxicity; metabolic syndrome; miRNA;
   NEFA; obesogenic environment; p53; ROS; SASP; senolytic; SIRT-1; VAT;
   Western-type diet
ID INSULIN-RECEPTOR SUBSTRATE-1; UNFOLDED PROTEIN RESPONSE; ADIPOSE-TISSUE;
   FATTY LIVER; MOLECULAR-MECHANISMS; ENERGY-EXPENDITURE; METABOLIC
   SYNDROME; GENE-EXPRESSION; NONCODING RNAS; IN-VIVO
AB This narrative review explores the pathophysiology of obesity, cellular senescence, and exosome release. When exposed to excessive nutrients, adipocytes develop mitochondrial dysfunction and generate reactive oxygen species with DNA damage. This triggers adipocyte hypertrophy and hypoxia, inhibition of adiponectin secretion and adipogenesis, increased endoplasmic reticulum stress and maladaptive unfolded protein response, metaflammation, and polarization of macrophages. Such feed-forward cycles are not resolved by antioxidant systems, heat shock response pathways, or DNA repair mechanisms, resulting in transmissible cellular senescence via autocrine, paracrine, and endocrine signaling. Senescence can thus affect preadipocytes, mature adipocytes, tissue macrophages and lymphocytes, hepatocytes, vascular endothelium, pancreatic beta cells, myocytes, hypothalamic nuclei, and renal podocytes. The senescence-associated secretory phenotype is closely related to visceral adipose tissue expansion and metaflammation; inhibition of SIRT-1, adiponectin, and autophagy; and increased release of exosomes, exosomal micro-RNAs, pro-inflammatory adipokines, and saturated free fatty acids. The resulting hypernefemia, insulin resistance, and diminished fatty acid beta-oxidation lead to lipotoxicity and progressive obesity, metabolic syndrome, and physical and cognitive functional decline. Weight cycling is related to continuing immunosenescence and exposure to palmitate. Cellular senescence, exosome release, and the transmissible senescence-associated secretory phenotype contribute to obesity and metabolic syndrome. Targeted therapies have interrelated and synergistic effects on cellular senescence, obesity, and premature aging.
C1 [Liang, Yicong] Univ New South Wales, Bankstown Hosp, Sydney, NSW 2560, Australia.
   [Kaushal, Devesh] Western Sydney Univ, Campbelltown Hosp, Sydney, NSW 2560, Australia.
   [Wilson, Robert Beaumont] Univ New South Wales, Sch Clin Med, High St, Sydney, NSW 2052, Australia.
C3 University of New South Wales Sydney; NSW Health; Bankstown Lidcombe
   Hospital; NSW Health; Campbelltown Hospital; Western Sydney University;
   University of New South Wales Sydney
RP Wilson, RB (corresponding author), Univ New South Wales, Sch Clin Med, High St, Sydney, NSW 2052, Australia.
EM z5083614@zmail.unsw.edu.au; d.kaushal@westernsydney.edu.au;
   robert.wilson@unsw.edu.au
OI Wilson, Robert/0000-0002-7408-4695
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NR 351
TC 3
Z9 3
U1 5
U2 15
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD JUL
PY 2024
VL 25
IS 14
AR 7943
DI 10.3390/ijms25147943
PG 61
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA ZR9K3
UT WOS:001277136300001
PM 39063184
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Kuckuck, S
   Lengton, R
   Boon, MR
   Boersma, E
   Penninx, BWJH
   Kavousi, M
   van Rossum, EFC
AF Kuckuck, Susanne
   Lengton, Robin
   Boon, Mariette R.
   Boersma, Eric
   Penninx, Brenda W. J. H.
   Kavousi, Maryam
   van Rossum, Elisabeth F. C.
TI Long-term glucocorticoids in relation to the metabolic syndrome and
   cardiovascular disease: A systematic review and meta-analysis
SO JOURNAL OF INTERNAL MEDICINE
LA English
DT Review
DE cardiovascular disease; cardiovascular risk factors; hair
   glucocorticoids; HPA-axis; metabolic syndrome
ID HAIR CORTISOL CONCENTRATIONS; SCALP HAIR; STRESS; RISK; TESTOSTERONE;
   EVENTS; HUMANS
AB The striking link of Cushing's syndrome with the metabolic syndrome (MetS) and cardiovascular disease (CVD) suggests that long-term exposure to extremely high cortisol levels catalyzes cardiometabolic deterioration. However, it remained unclear whether the findings from the extreme glucocorticoid overabundance observed in Cushing's syndrome could be translated into more subtle variations in long-term glucocorticoid levels among the general population, for example, due to chronic stress. Here, we performed a systematic review (PROSPERO: CRD42023425541) of evidence regarding the role of subtle variations in long-term biological stress, measured as levels of scalp hair cortisol (HairF) and cortisone (HairE), in the context of MetS and CVD in adults. We also performed a meta-analysis on the cross-sectional difference in HairF levels between individuals with versus without CVD. Seven studies were included regarding MetS, sixteen regarding CVD, and one regarding both. Most articles indicated a strong, consistent cross-sectional association of higher HairF and HairE levels with CVD, which was confirmed by our meta-analysis for HairF (eight studies, SMD = 0.48, 95% confidence intervals [CIs]: 0.16-0.79, p = 0.0095). Moreover, these relationships appear largely independent of standard risk factors. Age seems relevant as the effect seems stronger in younger individuals. Results regarding the associations of HairF and HairE with MetS were inconsistent. Altogether, long-term biological stress, measured as HairF and HairE, is associated with the presence of CVD, and less consistently with MetS. Prospective studies need to evaluate the directionality of this relationship and determine whether HairF and HairE can be used in addition to standard risk factors in predicting future cardiometabolic deterioration.
   image
C1 [Kuckuck, Susanne; Lengton, Robin; Boon, Mariette R.; van Rossum, Elisabeth F. C.] Univ Med Ctr Rotterdam, Erasmus MC, Dept Internal Med, Div Endocrinol, Rotterdam, Netherlands.
   [Kuckuck, Susanne; Lengton, Robin; Boon, Mariette R.; van Rossum, Elisabeth F. C.] Univ Med Ctr Rotterdam, Erasmus MC, Obes Ctr CGG, Rotterdam, Netherlands.
   [Kuckuck, Susanne; Kavousi, Maryam] Univ Med Ctr Rotterdam, Dept Epidemiol, Erasmus MC, Rotterdam, Netherlands.
   [Boersma, Eric] Univ Med Ctr Rotterdam, Dept Cardiol, Erasmus MC, Rotterdam, Netherlands.
   [Penninx, Brenda W. J. H.] Vrije Univ, Amsterdam UMC, Dept Psychiat, Amsterdam, Netherlands.
   [Penninx, Brenda W. J. H.] Vrije Univ, Amsterdam UMC, Amsterdam Publ Hlth, Amsterdam, Netherlands.
C3 Erasmus University Rotterdam; Erasmus MC; Erasmus University Rotterdam;
   Erasmus MC; Erasmus University Rotterdam; Erasmus MC; Erasmus University
   Rotterdam; Erasmus MC; University of Amsterdam; Vrije Universiteit
   Amsterdam; Vrije Universiteit Amsterdam; University of Amsterdam
RP van Rossum, EFC (corresponding author), Univ Med Ctr Rotterdam, Erasmus MC, Dept Internal Med, Div Endocrinol, Rotterdam, Netherlands.
EM e.vanrossum@erasmusmc.nl
RI Kavousi, Maryam/F-1174-2018; Boon, Mariëtte/O-3660-2016; van Rossum,
   Elisabeth/AAP-9388-2020; Penninx, Brenda/S-7627-2017
OI van Rossum, Elisabeth/0000-0003-0120-4913; Kuckuck,
   Susanne/0009-0003-8801-8781; Lengton, Robin/0000-0001-5666-4824
FU The authors wish to thank Wichor Bramer from the Erasmus MC Medical
   Library for developing the search strategies and to Priscilla Vlaming
   for statistical advice. We also wish to thank all the authors who
   provided us with additional information regarding th
FX The authors wish to thank Wichor Bramer from the Erasmus MC Medical
   Library for developing the search strategies and to Priscilla Vlaming
   for statistical advice. We also wish to thank all the authors who
   provided us with additional information regarding their articles. In
   addition, we would like to thank Annelieke Roest and Layal Chaker for
   their conceptual advice regarding meta-analyses. Finally, we acknowledge
   that Fig. 1 was created with BioRender.com.
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NR 67
TC 13
Z9 13
U1 2
U2 8
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0954-6820
EI 1365-2796
J9 J INTERN MED
JI J. Intern. Med.
PD JAN
PY 2024
VL 295
IS 1
BP 2
EP 19
DI 10.1111/joim.13739
EA NOV 2023
PG 18
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA CJ0O0
UT WOS:001100555200001
PM 37926862
OA hybrid
DA 2025-06-11
ER

PT J
AU Hishikawa, N
   Fukui, Y
   Sato, K
   Kono, S
   Yamashita, T
   Ohta, Y
   Deguchi, K
   Abe, K
AF Hishikawa, N.
   Fukui, Y.
   Sato, K.
   Kono, S.
   Yamashita, T.
   Ohta, Y.
   Deguchi, K.
   Abe, K.
TI Cognitive and affective functions in Alzheimer's disease patients with
   metabolic syndrome
SO EUROPEAN JOURNAL OF NEUROLOGY
LA English
DT Article
DE Alzheimer's disease; cognitive; affective functions; insulin resistance;
   metabolic syndrome; vascular endothelial function; vascular risk factors
ID INSULIN-RESISTANCE; DEMENTIA; RISK; DEPRESSION; IMPAIRMENT; SYMPTOMS
AB Background and purposeThe influence of metabolic syndrome (MetS) on cognitive and affective functions in patients with Alzheimer's disease (AD) was examined.
   MethodsA total of 570 AD patients were divided into two subgroups depending on waist circumference (WC) (normal versus achieving Japanese diagnostic criteria of MetS). Afterwards, the AD control subgroup was defined as those normal WC patients with no vascular risk factors (VRFs). The AD with MetS (AD-MetS) subgroup was defined as the MetS WC group who had two or more VRFs to qualify as having MetS. Cognitive and affective functions, insulin resistance, vascular endothelial function and white matter changes between AD-MetS and AD controls were compared.
   ResultsScores on the Mini-Mental State Examination, Hasegawa Dementia Score - Revised, Frontal Assessment Battery and Montreal Cognitive Assessment were worse in the AD-MetS group than in AD controls, but the difference was not significant. Some analyses were conducted twice, once including all patients and once including only late-elderly patients. Scores on the Geriatric Depression Scale were found to be significantly higher for AD-MetS than for AD controls (all ages, late-elderly), as were those for apathy (late-elderly). Furthermore, both the homeostasis model assessment of insulin resistance and reactive hyperemia index scores were significantly worse in AD-MetS than in AD controls, whilst white matter changes showed a tendency to be worse.
   ConclusionsGreater cognitive and affective decline occurs in patients with AD-MetS than in those without. Further, insulin resistance and vascular endothelial dysfunction are strongly correlated with AD-MetS before pathological white matter changes can be observed.
   Click to view the accompanying paper in this issue.
C1 [Hishikawa, N.; Fukui, Y.; Sato, K.; Kono, S.; Yamashita, T.; Ohta, Y.; Deguchi, K.; Abe, K.] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Neurol, Okayama 7008558, Japan.
C3 Okayama University
RP Abe, K (corresponding author), Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Neurol, Kita Ku, 2-5-1 Shikatacho, Okayama 7008558, Japan.
EM nozomi-hishikawa@okayama-u.ac.jp
OI Yamashita, Toru/0000-0003-3634-5679
FU Research Committees of the Ministry of Health, Labour and Welfare of
   Japan
FX This work was partly supported by Grants-in-Aid from the Research
   Committees of the Ministry of Health, Labour and Welfare of Japan.
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NR 19
TC 36
Z9 38
U1 0
U2 11
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1351-5101
EI 1468-1331
J9 EUR J NEUROL
JI Eur. J. Neurol.
PD FEB
PY 2016
VL 23
IS 2
BP 339
EP 345
DI 10.1111/ene.12845
PG 7
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA DB8WE
UT WOS:000368797100028
PM 26493280
DA 2025-06-11
ER

PT J
AU Wang, MH
   Shi, H
AF Wang, Miaohong
   Shi, Huan
TI Oxidative balance score is independently associated with reduced
   prevalence of sarcopenia among US adults with metabolic syndrome
SO FRONTIERS IN NUTRITION
LA English
DT Article
DE oxidative balance score; oxidative stress; sarcopenia; metabolic
   syndrome; NHANES
ID DEFINITION; SMOKING; FRAILTY; STRESS; CANCER; IRON; RISK
AB Background: This research seeks to explore the link between the oxidative balance score (OBS) and sarcopenia in American adults with Metabolic Syndrome (MetS) using data from a national, population-based survey. Methods: The study included 3,625 participants diagnosed with Metabolic Syndrome, all aged 20 years and above, derived from NHANES datasets spanning 1999-2006 and 2011-2018. OBS evaluation was based on 16 dietary and 4 lifestyle elements. MetS diagnosis followed the NCEP-ATP III guidelines, while sarcopenia identification was based on FNIH standards. We employed multivariate logistic regression analyses to delve into the connections between OBS and sarcopenia within the MetS cohort. Results: Sarcopenia was found in 17.46% of the participants. In models adjusted for all variables, OBS, dietary OBS, and lifestyle OBS each showed a significant inverse relationship with sarcopenia among MetS individuals [OBS: OR = 0.959, 95%CI: (0.948, 0.982), P trend = 0.0005; dietary OBS: OR = 0.963, 95%CI: (0.939, 0.989), P trend = 0.0055; lifestyle OBS: OR = 0.860, 95%CI: (0.787, 0.939), P trend = 0.0011]. Higher scores in OBS were consistently linked with a decreased incidence of sarcopenia (all P for trend < 0.05). Restricted cubic spline analysis confirmed that these relationships were linear. The impact of age was significant, with OBS benefits only observed in those aged 40 and older. Conclusions: Maintaining a diet and lifestyle rich in antioxidants is both independently and collectively linked with a lower occurrence of sarcopenia in individuals with MetS. These results bolster the proposition of developing OBS-centered preventive strategies for sarcopenia in MetS patients, particularly those aged 40 years and older.
C1 [Wang, Miaohong] Soochow Univ, Affiliated Hosp 3, Hlth Management Ctr, Changzhou, Peoples R China.
   [Shi, Huan] Soochow Univ, Affiliated Hosp 3, Dept Endocrinol, Changzhou, Peoples R China.
C3 Soochow University - China; Soochow University - China
RP Shi, H (corresponding author), Soochow Univ, Affiliated Hosp 3, Dept Endocrinol, Changzhou, Peoples R China.
EM lyw112288@163.com
FU Changzhou Science and Technology program [20210162]; Jiangsu Social
   Sciences Applied Research scheme [20SYB-111]
FX The author(s) declare that financial support was received for the
   research and/or publication of this article. This investigation was
   funded by the Changzhou Science and Technology program (Grant No.
   20210162) and the Jiangsu Social Sciences Applied Research scheme (Grant
   No. 20SYB-111).
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NR 55
TC 0
Z9 0
U1 1
U2 1
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD APR 8
PY 2025
VL 12
AR 1529140
DI 10.3389/fnut.2025.1529140
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 1RC3H
UT WOS:001471656100001
PM 40264554
OA gold
DA 2025-06-11
ER

PT J
AU Vidé, J
   Bonafos, B
   Fouret, G
   Benlebna, M
   Poupon, J
   Jover, B
   Casas, F
   Jouy, N
   Feillet-Coudray, C
   Gaillet, S
   Coudray, C
AF Vide, Joris
   Bonafos, Beatrice
   Fouret, Gilles
   Benlebna, Melha
   Poupon, Joel
   Jover, Bernard
   Casas, Francois
   Jouy, Nicolas
   Feillet-Coudray, Christine
   Gaillet, Sylvie
   Coudray, Charles
TI Spirulina platensis and silicon-enriched spirulina equally
   improve glucose tolerance and decrease the enzymatic activity of hepatic
   NADPH oxidase in obesogenic diet-fed rats
SO FOOD & FUNCTION
LA English
DT Article
ID FATTY LIVER-DISEASE; AMELIORATES METABOLIC SYNDROME; SPECTROPHOTOMETRIC
   ASSAY; RESPIRATORY-CHAIN; OXIDATIVE STRESS; INDUCED OBESITY;
   INFLAMMATION; STEATOSIS; GLUTATHIONE; PHYCOCYANIN
AB The prevalence of metabolic syndrome components, such as obesity, glucose intolerance and hepatic steatosis, is rapidly increasing and becoming a major issue of public health. The present work was designed to determine the effects of Spirulina platensis (Sp) algae and silicon-enriched Sp on major metabolic syndrome components in obesogenic diet-fed rats. Forty male Wistar rats were divided into 4 groups. Ten rats were fed a control diet and 30 rats were fed a high fat (HF) diet. The HF groups were divided into three groups and supplemented with placebo or Sp or Si-enriched Sp for 12 weeks. Dietary intake and body weight were recorded. Oral glucose tolerance test and surrogate metabolic syndrome (insulin, leptin, adiponectin and lipids), mitochondrial function (enzymatic activity of respiratory chain complexes and -hydroxyacyl-CoA dehydrogenase), NADPH oxidase activity and several long-established oxidative stress markers were measured in the blood and liver. The HF diet induced obesity, glucose intolerance, hepatic steatosis and huge metabolic alterations, associated with higher NADPH oxidase activity and lower hepatic sulfhydryl group and glutathione contents. Otherwise, the Sp and Sp + Si supplements showed some interesting effects on rat characteristics and particularly on blood and hepatic metabolic parameters. Indeed, the intake of Sp or Sp + Si mainly improved glucose tolerance and decreased the enzymatic activity of hepatic NADPH oxidase. Overall, Si supplementation of spirulina does not appear to have more beneficial effects than spirulina alone. Other experiments with different species of rats/mice, different diets or different durations of diet intake should be undertaken to confirm or invalidate these results.
C1 [Vide, Joris; Bonafos, Beatrice; Fouret, Gilles; Benlebna, Melha; Casas, Francois; Feillet-Coudray, Christine; Gaillet, Sylvie; Coudray, Charles] Univ Montpellier, INRA, DMEM, Montpellier, France.
   [Poupon, Joel] Hop Lariboisiere, Lab Toxicol Biol & Pharmacol, Paris, France.
   [Jover, Bernard] CNRS, UMR 9214, INSERM, U1046, Montpellier, France.
   [Jouy, Nicolas] Phycobiotech SAS, Montpellier, France.
C3 INRAE; Universite de Montpellier; Assistance Publique Hopitaux Paris
   (APHP); Universite Paris Cite; Hopital Universitaire
   Lariboisiere-Fernand-Widal - APHP; Institut National de la Sante et de
   la Recherche Medicale (Inserm); Universite de Montpellier; Centre
   National de la Recherche Scientifique (CNRS); CNRS - National Institute
   for Biology (INSB)
RP Coudray, C (corresponding author), Univ Montpellier, INRA, DMEM, Montpellier, France.
EM charles.coudray@inra.fr
RI COUDRAY, Charles/AGG-4757-2022
OI Francois, Casas/0000-0002-5535-8195; JOVER, Bernard/0000-0001-5826-5755
FU Occitanie region (France); European Regional Development Fund
FX The present results are part of the Spirulicium Cardio project,
   co-funded by the Occitanie region (France) and by the European Regional
   Development Fund. The authors wish to thank the Occitanie region and the
   European Regional Development Fund for their valuable support. The
   authors are deeply grateful to Drs Jean-Max Rouanet and Jean-Claude
   Baccou (scientific advisors to Phyco-Biotech) and Mr Gilbert Gay
   (President of Phyco-Biotech) for their major support and contribution to
   prepare and conclude this project. The authors also wish to thank the
   animal facility staff from METAMUS DMEM facility, which belongs to
   Montpellier animal facilities (RAM, BIOCAMPUS).
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NR 50
TC 12
Z9 13
U1 1
U2 25
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PD DEC 1
PY 2018
VL 9
IS 12
BP 6166
EP 6179
DI 10.1039/c8fo02037j
PG 14
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA HE3HP
UT WOS:000453244900007
PM 30431036
DA 2025-06-11
ER

PT J
AU Tsai, IJ
   Croft, KD
   Mori, TA
   Falck, JR
   Beilin, LJ
   Puddey, IB
   Barden, AE
AF Tsai, I-Jung
   Croft, Kevin D.
   Mori, Trevor A.
   Falck, John R.
   Beilin, Lawrence J.
   Puddey, Ian B.
   Barden, Anne E.
TI 20-HETE and F2-isoprostanes in the metabolic syndrome: the
   effect of weight reduction
SO FREE RADICAL BIOLOGY AND MEDICINE
LA English
DT Article
DE Plasma and urinary 20-HETE; F-2-isoprostanes; Metabolic syndrome; Weight
   reduction; Free radicals
ID URINARY 20-HYDROXYEICOSATETRAENOIC ACID;
   CHROMATOGRAPHY-MASS-SPECTROMETRY; OXIDATIVE STRESS; BLOOD-PRESSURE;
   CYTOCHROME-P450 ENZYMES; ENDOTHELIAL DYSFUNCTION; PLASMA
   F-2-ISOPROSTANES; ESSENTIAL-HYPERTENSION; ARACHIDONIC-ACID; HUMAN-KIDNEY
AB 20-Hydroxyeicosatetraenoic acid (20-HETE) is a cytochrome P450 metabolite of arachidonic acid that regulates vascular function and sodium homeostasis. Studies showing an association between 20-HETE excretion, raised BMI, and oxidative stress suggest that 20-HETE may be important in the development of cardiovascular disease in the metabolic syndrome (MetS). We investigated whether 20-HETE and F-2-isoprostanes (markets of oxidative stress) were altered in the MetS before and after weight reduction. A case-controlled comparison of 30 participants with the MetS and matched controls showed that plasma and urinary 20-HETE and F-2-isoprostanes were significantly elevated in the MetS group. There was a significant genderxgroup interaction such that women with the MetS had higher urinary 20-HETE and F-2-isoprostanes compared to controls (p<0.0001). In a randomized controlled trial, 42 participants with the MetS were assigned to 16 weeks of weight maintenance or a 12-week weight-loss program followed by 4 weeks weight stabilization. Relative to the weight-maintenance group, a 4-kg loss in weight resulted in a 2-mm Hg fall in blood pressure (BP) but did not alter urinary or plasma 20-HETE or F-2-isoprostanes. 20-HETE and oxidative stress may be important mediators of cardiovascular disease risk in the MetS. Although a 4% reduction in body weight reduced BP, there were no changes in plasma Or Urinary 20-HETE or F-2-isoprostanes. (C) 2008 Elsevier Inc. All rights reserved.
C1 [Tsai, I-Jung; Croft, Kevin D.; Mori, Trevor A.; Beilin, Lawrence J.; Puddey, Ian B.; Barden, Anne E.] Univ Western Australia, Royal Perth Hosp, Sch Med & Pharmacol, Perth, WA 6000, Australia.
   [Falck, John R.] Univ Texas SW Med Ctr Dallas, Dept Biochem, Dallas, TX 75390 USA.
C3 East Metropolitan Health Service; Royal Perth Hospital; University of
   Western Australia; University of Texas System; University of Texas
   Southwestern Medical Center Dallas
RP Barden, AE (corresponding author), Univ Western Australia, Royal Perth Hosp, Sch Med & Pharmacol, Perth, WA 6000, Australia.
EM anne.barden@uwa.edu.au
RI Croft, Kevin/C-4675-2013; Puddey, Ian/H-5673-2014; Mori,
   Trevor/H-5485-2014; Falck, John/B-3030-2011
OI Croft, Kevin/0000-0003-1596-4913; Beilin, Lawrence/0000-0003-4853-7360;
   Mori, Trevor A/0000-0002-5264-9229; Barden, Anne/0000-0001-7631-0767;
   Falck, John/0000-0002-9219-7845
FU National Heart Foundation of Australia
FX We thank Jackie Ritchie for her assistance with recruitment of
   participants for the study. This study was funded by a grant from the
   National Heart Foundation of Australia.
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NR 44
TC 69
Z9 78
U1 0
U2 2
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0891-5849
J9 FREE RADICAL BIO MED
JI Free Radic. Biol. Med.
PD JAN 15
PY 2009
VL 46
IS 2
BP 263
EP 270
DI 10.1016/j.freeradbiomed.2008.10.028
PG 8
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 394ZF
UT WOS:000262491000018
PM 19013235
DA 2025-06-11
ER

PT J
AU Pavagada, R
   Ko, KSW
   Lai, S
   Zeng, I
   Sanchez, D
   Ng, L
AF Pavagada, Rajendra
   Ko, Kitty S. W.
   Lai, Simon
   Zeng, Irene
   Sanchez, Denisse
   Ng, Lillian
TI Dual jeopardy for Indian service users: Qualitative study of managing
   comorbid schizophrenia and diabetes mellitus
SO AUSTRALASIAN PSYCHIATRY
LA English
DT Article; Early Access
DE Indian; antipsychotic medication; diabetes; comorbidity; culture
ID METABOLIC SYNDROME; PREVALENCE; PREDICTORS; ATTITUDES; BARRIERS; PEOPLE;
   WISHES
AB Objective Diabetes mellitus is a sequelae of antipsychotic medication in people of Indian descent with schizophrenia. The Indian socio-cultural context amplifies challenges of managing chronic illness. The aim of this study was to explore Indian mental health service users' perspectives of managing comorbid psychosis and diabetes mellitus, specifically culture-related difficulties.Methods In this exploratory study, people with an Indian cultural background recruited from community mental health clinics were interviewed by an Indian psychiatrist using a semi-structured questionnaire. Interviews were professionally transcribed. Reflexive thematic analysis was used to develop central organising concepts and identify themes.Results Four themes were identified: culture-specific views on comorbidity, preferences for tailoring education to Indian language and culture, changes in interpersonal relationships within extended family and relationships with healthcare professionals. Advice from hospital services was not specific to Indian culture and there were wider impacts of illness for wider family.Conclusion Indian New Zealanders have challenges in managing dual mental and physical illnesses. Further research is needed to develop approaches to care that emphasise service users' culture as core to understanding illness and treatment. This includes consideration of gender roles, families, communities, food, language, lifestyle and barriers to treatment.
C1 [Pavagada, Rajendra; Ko, Kitty S. W.; Zeng, Irene; Sanchez, Denisse; Ng, Lillian] Hlth New Zealand Te Whatu Ora Cty Manukau, Dept Mental Hlth & Addict, 100 Hosp Rd, Auckland 1640, New Zealand.
   [Lai, Simon; Sanchez, Denisse; Ng, Lillian] Univ Auckland, Dept Psychol Med, Auckland, New Zealand.
C3 University of Auckland
RP Sanchez, D (corresponding author), Hlth New Zealand Te Whatu Ora Cty Manukau, Dept Mental Hlth & Addict, 100 Hosp Rd, Auckland 1640, New Zealand.
EM denisse.sanchez@auckland.ac.nz
RI Zeng, Irene/AEV-0662-2022; Sanchez, Denisse/LUA-0431-2024; Ng,
   Lillian/AFP-0009-2022
OI Zeng, Irene Suilan/0000-0001-8100-3120; /0000-0002-5839-0414; Ng,
   Lillian/0000-0002-7189-1272; Lai, Simon/0000-0002-4016-7900
FU Te Whatu Ora Counties Manukau
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: This study
   is supported by Te Whatu Ora Counties Manukau for a Tupu Research Award.
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NR 26
TC 0
Z9 0
U1 0
U2 0
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1039-8562
EI 1440-1665
J9 AUSTRALAS PSYCHIATRY
JI Australas. Psychiatry
PD 2025 FEB 1
PY 2025
DI 10.1177/10398562251316145
EA FEB 2025
PG 7
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA U2Y9S
UT WOS:001410522500001
PM 39891583
DA 2025-06-11
ER

PT J
AU Li, JX
   Liu, Y
   Li, JJ
   Feng, ZW
   Bai, LL
   Feng, YJ
   Zhang, PY
   Song, FJ
AF Li, Junxian
   Liu, Ya
   Li, Jingjing
   Feng, Ziwei
   Bai, Lili
   Feng, Yujie
   Zhang, Pengyu
   Song, Fengju
TI Association between the oxidative balance score with metabolic syndrome
   traits in US adults
SO DIABETOLOGY & METABOLIC SYNDROME
LA English
DT Article
DE Oxidative Balance Score; Metabolic Syndrome; Fasting blood glucose;
   Dietary; Lifestyle
ID STRESS; ANTIOXIDANTS; RISK; INFLAMMATION; MORTALITY; MARKERS; CANCER;
   HEALTH
AB ObjectiveTo explore the association between the Oxidative Balance Score (OBS), which represents the balance of multiple oxidative stress-related dietary and lifestyle exposures, and the risk of metabolic syndrome (MetS).MethodsA population-based cross-sectional study design was adopted and 16,850 participants in NHANES database were included in the statistics analysis stage. The OBS was constructed by combining information from 20 a priori selected pro- and antioxidant factors. Weighted logistic regression and restricted cubic splines (RCS) were used to estimate the association between OBS and MetS.ResultsParticipants in the highest OBS quartile, indicating low oxidative stress (OS) levels, exhibited a significantly lower risk of MetS (odds Ratio [OR] = 0.55, 95% confidence Interval [CI]: 0.47-0.64) compared to the lowest quartile. Specifically, higher OBS was inversely associated with abdominal obesity (OR = 0.61, 95% CI: 0.54-0.69), hypertension (OR = 0.69, 95% CI: 0.58-0.83), elevated triglycerides (OR = 0.68, 95% CI: 0.57-0.82), low high-density lipoprotein cholesterol (HDL-C) levels (OR = 0.60, 95% CI: 0.50-0.70) and fasting blood glucose (FBG) levels (OR = 0.74, 95% CI: 0.62-0.88). The observed inverse association between OBS and hypertension or FBG levels appeared to primarily influenced by BMI. The association between dietary OBS intervals and elevated FBG levels was not statistically significant in men, whereas the risk was lower by 25% in women.ConclusionsA higher OBS, representing a balance of multiple oxidative stress-related dietary and lifestyle exposures, is associated with a lower risk of MetS. Therefore, adhering to an antioxidant diet and lifestyle may help prevent the occurrence of metabolic disorders.
C1 [Li, Junxian; Bai, Lili; Feng, Yujie; Zhang, Pengyu] Tianjin Med Univ Canc Inst & Hosp, Key Lab Canc Prevent & Therapy Tianjin, Tianjins Clin Res Ctr Canc, Dept Blood Transfus,Natl Clin Res Ctr Canc, Tianjin, Peoples R China.
   [Li, Junxian; Liu, Ya; Li, Jingjing; Song, Fengju] Tianjin Med Univ Canc Inst & Hosp, Tianjins Clin Res Ctr Canc, Key Lab Mol Canc Epidemiol Tianjin, Natl Clin Res Ctr Canc,Dept Epidemiol & Biostat, Tianjin, Peoples R China.
   [Feng, Ziwei] Tianjin Med Univ Canc Inst & Hosp, Natl Clin Res Ctr Canc, Tianjins Clin Res Ctr Canc, Nosocomial Infect Management Dept,Key Lab Mol Canc, Tianjin, Peoples R China.
C3 Tianjin Medical University; Tianjin Medical University; Tianjin Medical
   University
RP Song, FJ (corresponding author), Tianjin Med Univ Canc Inst & Hosp, Tianjins Clin Res Ctr Canc, Key Lab Mol Canc Epidemiol Tianjin, Natl Clin Res Ctr Canc,Dept Epidemiol & Biostat, Tianjin, Peoples R China.
EM songfengju@163.com
RI Feng, Ziwei/GPX-7610-2022; Zhang, Pengyu/JRW-3285-2023; Li,
   Junxian/GZM-5940-2022
FU Introduction of talents and doctoral start-up fund of Tianjin Medical
   University Cancer Institute and Hospital
FX The authors want to acknowledge the participants and investigators of
   the NHANES datasets analyzed in this study, for sharing them publicly
   for research.
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   Zhu Q, 2023, FRONT ENDOCRINOL, V14, DOI 10.3389/fendo.2023.1180903
NR 42
TC 3
Z9 3
U1 3
U2 3
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1758-5996
J9 DIABETOL METAB SYNDR
JI Diabetol. Metab. Syndr.
PD NOV 5
PY 2024
VL 16
IS 1
AR 263
DI 10.1186/s13098-024-01500-y
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA L0S4G
UT WOS:001347904200002
PM 39497207
OA gold
DA 2025-06-11
ER

PT J
AU Guo, F
   Tian, Y
   Zhong, F
   Wu, CC
   Cui, YF
   Huang, C
AF Guo, Feng
   Tian, Ying
   Zhong, Fei
   Wu, Chunchun
   Cui, Yufei
   Huang, Cong
TI Intensity of Physical Activity and Depressive Symptoms in College
   Students: Fitness Improvement Tactics in Youth (FITYou) Project
SO PSYCHOLOGY RESEARCH AND BEHAVIOR MANAGEMENT
LA English
DT Article
DE physical activity intensity; mental health; Chinese youth;
   cross-sectional study
ID WHITE-MATTER INTEGRITY; BODY-IMAGE; EXERCISE; ASSOCIATIONS; ANXIETY
AB Purpose: To investigate whether the physical activity at different intensities is correlated with depressive symptoms in college students.
   Patient and Methods: This cross-sectional study was a part of the Fitness Improvement Tactics in Youth Project, which was conducted in 2017. A total of 2,820 college freshmen aged 15-24 years were included in this study, of whom 699 (24.8%) were males and 2,121 (75.2%) were females. Depressive symptoms were measured using the Self-rating Depression Scale. Physical activity was assessed using the International Physical Activity Questionnaire-Short Form. Covariates included sociodemographic, lifestyle-related, and health-related factors.
   Results: A total of 560 (19.9%) college students had depressive symptoms. Total physical activity levels (METs.hour/week) were positively associated with frequency of breakfast intake (p = 0.050) but no other participant characteristics. Logistic regression analysis showed that the prevalence of depressive symptoms in the highest quartile of physical activity was lower than in the lowest quartile when adjusted for sex, age, ethnicity, only child, smoking status, alcohol use, breakfast frequency, daily sleep duration, body mass index, grip strength, and the number of metabolic syndrome components (odds ratios [95% confidence intervals (CI)]: 0.75 [0.58, 0.98], p = 0.036). Furthermore, high physical activity levels of low-intensity tended to moderately correlate to lower prevalence of depressive symptoms (odds ratios [95% CI]: Q1, 0.71 [0.55, 0.91], Q2, 0.77 [0.59, 1.01], Q3, 0.75 [0.57, 0.98], p for trend = 0.037). Associations of moderate and vigorous physical activity with depressive symptoms were not found. For secondary outcomes, sex-stratified analysis showed that similar findings were only found in females, but not males.
   Conclusion: This study indicated that total physical activity and low-intensity physical activity were inversely associated with depressive symptoms in Chinese college students. All these observations showed gender differences.
C1 [Guo, Feng; Cui, Yufei] Huaiyin Inst Technol, Inst Exercise Epidemiol, Huaian 223003, Peoples R China.
   [Guo, Feng; Cui, Yufei] Huaiyin Inst Technol, Dept Phys Educ, Huaian 223003, Peoples R China.
   [Tian, Ying] Shenyang Normal Univ, Coll Sports Sci, Shenyang, Peoples R China.
   [Zhong, Fei; Wu, Chunchun; Huang, Cong] Zhejiang Univ, Coll Educ, Dept Sports & Exercise Sci, 148 Tianmushan Rd, Hangzhou 310007, Peoples R China.
   [Huang, Cong] Tohoku Univ, Grad Sch Med, Dept Med & Sci Sports & Exercise, Sendai, Miyagi, Japan.
C3 Huaiyin Institute of Technology; Huaiyin Institute of Technology;
   Shenyang Normal University; Zhejiang University; Tohoku University
RP Guo, F (corresponding author), Huaiyin Inst Technol, Inst Exercise Epidemiol, Huaian 223003, Peoples R China.; Guo, F (corresponding author), Huaiyin Inst Technol, Dept Phys Educ, Huaian 223003, Peoples R China.; Huang, C (corresponding author), Zhejiang Univ, Coll Educ, Dept Sports & Exercise Sci, 148 Tianmushan Rd, Hangzhou 310007, Peoples R China.
EM kakuhoulove@hotmail.com; cohuang@zju.edu.cn
RI Huang, Cong/N-4401-2019; GUO, FENG/JRX-3555-2023
OI Wu, Chunchun/0000-0002-5173-3031; Huang, Cong/0000-0002-2307-864X
FU Zhejiang University [188020*194221802/004/001]
FX The present study was partially supported by the "Hundred Talents
   Program" funding from Zhejiang University (188020*194221802/004/001).
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NR 44
TC 10
Z9 12
U1 1
U2 26
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1179-1578
J9 PSYCHOL RES BEHAV MA
JI Psychol. Res. Behav. Manag.
PY 2020
VL 13
BP 787
EP 796
DI 10.2147/PRBM.S267066
PG 10
WC Psychology, Clinical; Psychiatry; Psychology, Multidisciplinary
WE Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA NW3IL
UT WOS:000574902600001
PM 33061694
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Beach, SRH
   Lei, MK
   Brody, GH
   Kim, S
   Barton, AW
   Dogan, MV
   Philibert, RA
AF Beach, Steven R. H.
   Lei, Man-Kit
   Brody, Gene H.
   Kim, Sangjin
   Barton, Allen W.
   Dogan, Meesha V.
   Philibert, Robert A.
TI Parenting, Socioeconomic Status Risk, and Later Young Adult Health:
   Exploration of Opposing Indirect Effects via DNA Methylation
SO CHILD DEVELOPMENT
LA English
DT Article
ID METABOLIC SYNDROME; CHILDHOOD; STRESS; INFLAMMATION; DISPARITIES;
   DEPRESSION; EXPERIENCE; CONFLICT; FAMILIES; DISEASES
AB A sample of 398 African American youth, residing in rural counties with high poverty and unemployment, were followed from ages 11 to 19. Protective parenting was associated with better health, whereas elevated socioeconomic status (SES) risk was associated with poorer health at age 19. Genome-wide epigenetic variation assessed in young adulthood (age 19), was associated with both SES risk and protective parenting. Three categories of genes were identified whose methylation was associated with parenting, SES risk, and young adult health. Methylation was a significant mediator of the impact of parenting and SES risk on young adult health. Variation in mononuclear white blood cell types was also examined and controlled, showing that it did not account for observed effects of parenting and SES risk on health.
C1 [Beach, Steven R. H.; Lei, Man-Kit; Brody, Gene H.; Kim, Sangjin; Barton, Allen W.] Univ Georgia, Athens, GA 30602 USA.
   [Dogan, Meesha V.; Philibert, Robert A.] Univ Iowa, Iowa City, IA 52242 USA.
C3 University System of Georgia; University of Georgia; University of Iowa
RP Beach, SRH (corresponding author), Univ Georgia, Ctr Family Res, 1095 Coll Stn Rd, Athens, GA 30602 USA.
EM srhbeach@uga.edu
RI Lei, Man/AAM-9616-2020; Beach, Steven/MBH-1541-2025
OI Lei, Man-Kit/0000-0002-7757-6548; Philibert, Robert/0000-0001-7822-4977
FU National Institute of Child Health and Human Development
   [5R01HD030588-16A1]; National Institute on Drug Abuse [1P30DA027827]
FX This research was supported by Award 5R01HD030588-16A1 from the National
   Institute of Child Health and Human Development and Award 1P30DA027827
   from the National Institute on Drug Abuse. The content is solely the
   responsibility of the authors and does not necessarily represent the
   official views of the National Institute of Child Health and Human
   Development, the National Institute on Drug Abuse, or the National
   Institutes of Health.
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NR 46
TC 36
Z9 40
U1 0
U2 32
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0009-3920
EI 1467-8624
J9 CHILD DEV
JI Child Dev.
PD JAN-FEB
PY 2016
VL 87
IS 1
BP 111
EP 121
DI 10.1111/cdev.12486
PG 11
WC Psychology, Educational; Psychology, Developmental
WE Social Science Citation Index (SSCI)
SC Psychology
GA DD3UK
UT WOS:000369848300009
PM 26822447
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Mansouri, E
   Asghari, S
   Nikooei, P
   Yaseri, M
   Vasheghani-Farahani, A
   Hosseinzadeh-Attar, MJ
AF Mansouri, Elahe
   Asghari, Somayyeh
   Nikooei, Parinaz
   Yaseri, Mehdi
   Vasheghani-Farahani, Ali
   Hosseinzadeh-Attar, Mohammad Javad
TI Effects of virgin coconut oil consumption on serum brain-derived
   neurotrophic factor levels and oxidative stress biomarkers in adults
   with metabolic syndrome: a randomized clinical trial
SO NUTRITIONAL NEUROSCIENCE
LA English
DT Article
DE Metabolic syndrome; brain-derived neurotrophic factor; virgin coconut
   oil; oxidative stress; insulin resistance; clinical trial; antioxidant
   status; neurodegenerative disease ‌
ID CHAIN FATTY-ACID; ANTIOXIDANT STATUS; ASYMMETRIC DIMETHYLARGININE;
   DIETARY FATS; OBESITY; EXPRESSION; DISEASES; MARKERS; MICE
AB Background and aim: Metabolic syndrome is associated with health conditions and neurological disorders. Brain-derived neurotrophic factor (BDNF) plays a protective role on the nervous system. Decreased levels of BDNF have been shown in MetS and neurodegenerative diseases. There is promising evidence regarding the anti-inflammatory antioxidant, and neuroprotective properties of virgin coconut oil (VCO). The aim of this study was to evaluate the effects of VCO consumption on serum BDNF levels, oxidative stress status, and insulin resistance in adults with MetS.Methods: This randomized controlled clinical trial was conducted on 48 adults with MetS aged 20-50 years. The intervention group received 30 ml of VCO daily to substitute the same amounts of oil in their usual diet. The control group continued their usual diet. Serum BDNF levels, total antioxidant capacity (TAC), malondialdehyde (MDA) as well as HOMA-IR and QUICKI index were measured after four weeks of intervention.Results: VCO consumption significantly reduced serum levels of MDA (p = .01), fasting insulin (p < .01) and HOMA-IR index (p < .01) and increased serum TAC (p < .01) and QUICKI index (p = .01) compared to the control group. Serum BDNF levels increased significantly in VCO group compared to the baseline (p = .02); however, this change was not significant when compared to the control group (p = .07).Conclusion: VCO consumption improved oxidative stress status and insulin resistance and had a promising effect on BDNF levels in adults with MetS. Further studies are needed to understand the long-term effects of VCO consumption.
C1 [Mansouri, Elahe; Asghari, Somayyeh; Nikooei, Parinaz; Hosseinzadeh-Attar, Mohammad Javad] Univ Tehran Med Sci, Fac Nutr Sci & Dietet, Dept Clin Nutr, Tehran, Iran.
   [Yaseri, Mehdi] Univ Tehran Med Sci, Dept Epidemiol & Biostat, Tehran, Iran.
   [Vasheghani-Farahani, Ali] Univ Tehran Med Sci, Cardiac Primary Prevent Res Ctr CPPRC, Tehran Heart Ctr, Tehran, Iran.
   [Vasheghani-Farahani, Ali] Univ Tehran Med Sci, Tehran Heart Ctr, Dept Clin Cardiac Electrophysiol, Tehran, Iran.
   [Hosseinzadeh-Attar, Mohammad Javad] Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Clin Nutr, 44 Hojjatdoust St,Naderi St,Keshavarz Blvd, Tehran 141556117, Iran.
C3 Tehran University of Medical Sciences; Tehran University of Medical
   Sciences; Tehran University of Medical Sciences; Tehran University of
   Medical Sciences; Tehran University of Medical Sciences
RP Hosseinzadeh-Attar, MJ (corresponding author), Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Clin Nutr, 44 Hojjatdoust St,Naderi St,Keshavarz Blvd, Tehran 141556117, Iran.
EM hosseinzadeh.md.phd@gmail.com
RI Hosseinzadeh-Attar, Mohammad/E-9358-2018; Farahani, Ali/L-6076-2018;
   Yaseri, Mehdi/I-1645-2018
FU Tehran University of Medical Sciences
FX This work was supported by the Tehran University of Medical Sciences.
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NR 60
TC 5
Z9 5
U1 2
U2 5
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1028-415X
EI 1476-8305
J9 NUTR NEUROSCI
JI Nutr. Neurosci.
PD MAY 3
PY 2024
VL 27
IS 5
BP 487
EP 498
DI 10.1080/1028415X.2023.2223390
EA JUL 2023
PG 12
WC Neurosciences; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Nutrition & Dietetics
GA MS5C6
UT WOS:001024928100001
PM 37409587
DA 2025-06-11
ER

PT J
AU Rezazadeh, L
   Alipour, B
   Jafarabadi, MA
   Behrooz, M
   Gargari, BP
AF Rezazadeh, Leila
   Alipour, Beitullah
   Jafarabadi, Mohammad Asghari
   Behrooz, Maryam
   Gargari, Bahram Pourghassem
TI Daily consumption effects of probiotic yogurt containing
   Lactobacillus acidophilus La5 and Bifidobacterium
   lactis Bb12 on oxidative stress in metabolic syndrome patients
SO CLINICAL NUTRITION ESPEN
LA English
DT Article
DE Probiotic yogurt; Oxdized LDL; Uric acid; Malondialdehyde; Total
   antioxidant capacity
AB Background and aims: Available evidence substantiates a strong association between metabolic syndrome and elevated oxidative stress. This study was aimed to assess the effects of probiotic yogurt containing Lactobacillus acidophilus La5 and Bifidobacterium lactis Bb12 on the oxidative stress biomarkers in patients with metabolic syndrome. Furthermore, the association between uric acid levels and insulin resistance indexes was assessed.
   Methods: An 8-week randomized, double-blind, placebo-controlled, parallel study was designed. Forty-four patients, 22 males and 22 females aged 20-65 years, were assigned into two groups. Treatment (n = 22) and control (n = 22) groups consumed 300 g/d of probiotic and regular yogurt, respectively. The serum concentration of uric acid, oxidized Low-Density Lipoprotein (oxLDL), Malondialdehyde (MDA) and Total Antioxidant Capacity (TAC) were measured at the beginning and the end of the trial. This study was recorded at http://www.irct.ir (code: IRCT201608213140N17).
   Results: Probiotic yogurt consumption resulted in a significant decrease in the level of serum uric acid and a significant increase in the level of TAC (p < 0.05). A positive significant association between uric acid with insulin concentration and the homeostasis model assessment of insulin resistance (HOMA-IR) and an inverse significant relationship with insulin sensitivity (Quicki) were also found (p < 0.05).
   Conclusion: Probiotic yogurt consumption through improvement in insulin sensitivity may exert positive effects on the oxidative stress and uric acid levels. However, further studies are needed to make concise conclusions. (C) 2020 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights reserved.
C1 [Rezazadeh, Leila] Tabriz Univ Med Sci, Fac Nutr & Food Sci, Dept Biochem & Diet Therapy, Student Res Comm, Tabriz, Iran.
   [Alipour, Beitullah] Tabriz Univ Med Sci, Fac Nutr & Food Sci, Dept Community Nutr, Tabriz, Iran.
   [Jafarabadi, Mohammad Asghari] Tabriz Univ Med Sci, Fac Hlth, Dept Stat & Epidemiol, Rd Traff Injury Res Ctr, Tabriz, Iran.
   [Behrooz, Maryam] Tabriz Univ Med Sci, Fac Nutr & Food Sci, Student Res Comm, Tabriz, Iran.
   [Gargari, Bahram Pourghassem] Tabriz Univ Med Sci, Fac Nutr & Food Sci, Nutr Res Ctr, Dept Biochem & Diet Therapy, Tabriz, Iran.
C3 Tabriz University of Medical Science; Tabriz University of Medical
   Science; Tabriz University of Medical Science; Tabriz University of
   Medical Science; Tabriz University of Medical Science
RP Gargari, BP (corresponding author), Tabriz Univ Med Sci, Attar Neyshaboori St,Golgasht Ave, Tabriz 516661471, Iran.
EM rezazadehleila@yahoo.com; alipourb@tbzmed.ac.ir; mm.behroozp@gmail.com;
   pourghassemb@tbzmed.ac.ir
RI Rezazadeh (PhD in Nutrition), Dr. Leila/AAE-3219-2022; Asghari
   Jafarabadi, Mohammmad/A-7478-2017; Pourghassem Gargari,
   Bahram/D-3556-2017
OI Asghari Jafarabadi, Mohammmad/0000-0003-3284-9749; Behrooz,
   maryam/0000-0003-1544-1362; Pourghassem Gargari,
   Bahram/0000-0001-7667-099X
FU Tabriz University of Medical Sciences, Tabriz, Iran [5/4/12238,
   5/D/95423]
FX This study was funded by the Research Vice-Chancellor of Tabriz
   University of Medical Sciences, Tabriz, Iran; Grant numbers [5/4/12238,
   5/D/95423]. The results of this article are derived from the Ph.D.
   thesis of Leila Rezazadeh [No. D/P/4] registered in the Tabriz
   University of Medical Sciences, Tabriz, Iran. The authors would like to
   thank the staff of Student Research center for their kindly cooperation
   in this study and Pegah Dairy Industries Co. [Tabriz, Iran] for
   supplying the probiotic and regular yogurts.This study would not be able
   to accomplish without the help and participation of patients. L. R:
   performanced study, analysed data, prepared manuscript, B. A: analysed
   data, prepared manuscript, M. A. J: analysed data, M. B: performanced
   study, B. P. G: designed study, performanced study, prepared and
   reviewed manuscript.
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NR 42
TC 31
Z9 40
U1 2
U2 48
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2405-4577
J9 CLIN NUTR ESPEN
JI Clin. Nutr. ESPEN
PD FEB
PY 2021
VL 41
BP 136
EP 142
DI 10.1016/j.clnesp.2020.12.003
PG 7
WC Nutrition & Dietetics
WE Emerging Sources Citation Index (ESCI)
SC Nutrition & Dietetics
GA QB4QM
UT WOS:000614125200018
PM 33487257
DA 2025-06-11
ER

PT J
AU Panchal, SK
   Poudyal, H
   Arumugam, TV
   Brown, L
AF Panchal, Sunil K.
   Poudyal, Hemant
   Arumugam, Thiruma V.
   Brown, Lindsay
TI Rutin Attenuates Metabolic Changes, Nonalcoholic Steatohepatitis, and
   Cardiovascular Remodeling in High-Carbohydrate, High-Fat Diet-Fed Rats
SO JOURNAL OF NUTRITION
LA English
DT Article
ID LIVER-DISEASE; HEPATIC STEATOSIS; OXIDATIVE STRESS; INFLAMMATORY
   MEDIATORS; ANTIOXIDANT STATUS; QUERCETIN; IMPROVES; FRUCTOSE;
   DYSFUNCTION; HYDROXYETHYLRUTOSIDES
AB Metabolic syndrome (obesity, diabetes, and hypertension) increases hepatic and cardiovascular damage. This study investigated preventive or reversal responses to rutin in high-carbohydrate, high-fat diet-fed rats as a model of metabolic syndrome. Rats were divided into 6 groups: 2 groups were fed a corn starch-rich diet for 8 or 16 wk, 2 groups were fed a high-carbohydrate, high-fat diet for 8 or 16 wk, and 2 groups received rutin (1.6 g/kg diet) in either diet for the last 8 wk only of the 16-wk protocol. Metabolic changes and hepatic and cardiovascular structure and function were then evaluated in these rats. The corn starch-rich diet contained 68% carbohydrate (mainly cornstarch) and 0.7% fat, whereas the high-carbohydrate, high-fat diet contained 50% carbohydrate (mainly fructose) and 24% fat (mainly beef tallow) along with 25% fructose in drinking water (total 68% carbohydrate using mean food and water intakes). The high-carbohydrate, high-fat diet produced obesity, dyslipidemia, hypertension, impaired glucose tolerance, hepatic steatosis, infiltration of inflammatory cells in the liver and the heart, higher cardiac stiffness, endothelial dysfunction, and higher plasma markers of oxidative stress with lower expression of markers for oxidative stress and apoptosis in the liver. Rutin reversed or prevented metabolic changes such as abdominal fat pads and glucose tolerance, reversed or prevented changes in hepatic and cardiovascular structure and function, reversed oxidative stress and inflammation in the liver and heart, and normalized expression of liver markers. These results suggest a non-nutritive role for rutin to attenuate chronic changes in metabolic syndrome. J. Nutr. 141: 1062-1069, 2011.
C1 [Panchal, Sunil K.; Brown, Lindsay] Univ So Queensland, Dept Biol & Phys Sci, Toowoomba, Qld 4350, Australia.
   [Panchal, Sunil K.; Poudyal, Hemant; Arumugam, Thiruma V.; Brown, Lindsay] Univ Queensland, Sch Biomed Sci, Brisbane, Qld 4072, Australia.
C3 University of Southern Queensland; University of Queensland
RP Brown, L (corresponding author), Univ So Queensland, Dept Biol & Phys Sci, Toowoomba, Qld 4350, Australia.
EM Lindsay.Brown@usq.edu.au
RI Arumugam, Thiruma/AAG-6958-2019; Poudyal, Hemant/HOH-9324-2023
OI Arumugam, Thiruma/0000-0002-3377-0939; Panchal, Sunil
   K/0000-0001-5464-3376
FU Dr. Red Nutraceuticals, Brisbane, Australia; Prince Charles Hospital
   Foundation, Brisbane, Australia
FX Supported by Dr. Red Nutraceuticals, Brisbane, Australia and The Prince
   Charles Hospital Foundation, Brisbane, Australia.
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NR 58
TC 145
Z9 157
U1 1
U2 27
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0022-3166
EI 1541-6100
J9 J NUTR
JI J. Nutr.
PD JUN
PY 2011
VL 141
IS 6
BP 1062
EP 1069
DI 10.3945/jn.111.137877
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 768GK
UT WOS:000290921700007
PM 21508207
OA Bronze
DA 2025-06-11
ER

PT J
AU Choromanska, B
   Mysliwiec, P
   Luba, M
   Wojskowicz, P
   Dadan, J
   Mysliwiec, H
   Choromanska, K
   Zalewska, A
   Maciejczyk, M
AF Choromanska, Barbara
   Mysliwiec, Piotr
   Luba, Magdalena
   Wojskowicz, Piotr
   Dadan, Jacek
   Mysliwiec, Hanna
   Choromanska, Katarzyna
   Zalewska, Anna
   Maciejczyk, Mateusz
TI A Longitudinal Study of the Antioxidant Barrier and Oxidative Stress in
   Morbidly Obese Patients after Bariatric Surgery. Does the Metabolic
   Syndrome Affect the Redox Homeostasis of Obese People?
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Article
DE oxidative stress; redox biomarkers; morbid obesity; bariatric surgery
ID GLYCATION END-PRODUCTS; INSULIN-RESISTANCE; GLUTATHIONE-REDUCTASE;
   PROTEIN OXIDATION; FREE-RADICALS; ASSOCIATION; MARKERS
AB This is the first study to evaluate both the antioxidant barrier, glutathione metabolism, and oxidative damage to proteins and lipids in morbidly obese patients undergoing bariatric treatment. The study included 65 patients with class 3 obesity divided into two subgroups: morbidly obese patients without metabolic syndrome (OB) and obese patients with metabolic syndrome (OB + MS). Blood samples were collected before surgery as well as one, three, six, and twelve months after the bariatric treatment. Superoxide dismutase and reduced glutathione (GSH) were significantly decreased, whereas glutathione reductase and uric acid were enhanced in morbidly obese patients before bariatric surgery as compared to lean control. Moreover, in the OB group, we observed the increase of superoxide dismutase (SOD) and the decrease of uric acid (UA) after the bariatric treatment; however, these changes were not observed in the OB + MS group. The oxidative damage to proteins (advanced glycation end products, AGE; advanced oxidation protein products, AOPP) and lipids (8-isoprostanes, 8-isop; 4-hydroxynoneal) was higher in OB as well as OB + MS patients. We noticed that AGE and AOPP levels diminished after the bariatric treatment, whereas redox status (ratio of GSH to oxidized glutathione) was still reduced in the OB + MS group. Summarizing, morbid obesity is associated with disturbances in the antioxidant barrier and enhanced oxidative damage to proteins and lipids. Although bariatric surgery improves redox homeostasis in obese patients, those with metabolic syndrome show a continuous decrease in the antioxidant status. In patients undergoing bariatric treatment, antioxidant supplementation may be considered.
C1 [Choromanska, Barbara; Mysliwiec, Piotr; Luba, Magdalena; Wojskowicz, Piotr; Dadan, Jacek] Med Univ Bialystok, Dept Gen & Endocrine Surg, 24a M Sklodowskiej Curie St, PL-15276 Bialystok, Poland.
   [Mysliwiec, Hanna] Med Univ Bialystok, Dept Dermatol & Venereol, 14 Zurawia St, PL-15540 Bialystok, Poland.
   [Choromanska, Katarzyna] Med Univ Gdansk, Dept Oral Surg, 7 Debinki St, PL-80211 Gdansk, Poland.
   [Zalewska, Anna] Med Univ Bialystok, Expt Dent Lab, 24a M Sklodowskiej Curie St, PL-15274 Bialystok, Poland.
   [Maciejczyk, Mateusz] Med Univ Bialystok, Dept Hyg Epidemiol & Ergon, 2c Mickiewicza St, PL-15233 Bialystok, Poland.
C3 Medical University of Bialystok; Medical University of Bialystok;
   Fahrenheit Universities; Medical University Gdansk; Medical University
   of Bialystok; Medical University of Bialystok
RP Choromanska, B (corresponding author), Med Univ Bialystok, Dept Gen & Endocrine Surg, 24a M Sklodowskiej Curie St, PL-15276 Bialystok, Poland.; Maciejczyk, M (corresponding author), Med Univ Bialystok, Dept Hyg Epidemiol & Ergon, 2c Mickiewicza St, PL-15233 Bialystok, Poland.
EM barbara.choromanska@umb.edu.pl; piotr.a.mysliwiec@gmail.com;
   ananau@wp.pl; pwojsk@wp.pl; jacdad@poczta.onet.pl;
   hanna.mysliwiec@gmail.com; kasia24_89@o2.pl; azalewska426@gmail.com;
   mat.maciejczyk@gmail.com
RI Myśliwiec, Piotr/T-4220-2018; Myśliwiec, Hanna/S-6326-2018; Zalewska,
   Anna/AAG-9484-2019; Maciejczyk, Mateusz/R-6568-2018
OI Maciejczyk, Mateusz/0000-0001-5609-3187; Zalewska,
   Anna/0000-0003-4562-0951
FU Medical University of Bialystok, Poland [SUB/1/DN/20/002/1209,
   SUB/1/DN/20/002/3330, SUB/1/DN/19/003/1140]
FX This work was supported by grants from the Medical University of
   Bialystok, Poland (grant numbers: SUB/1/DN/20/002/1209;
   SUB/1/DN/20/002/3330; SUB/1/DN/19/003/1140).
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NR 69
TC 31
Z9 32
U1 0
U2 4
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD APR
PY 2020
VL 9
IS 4
AR 976
DI 10.3390/jcm9040976
PG 20
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA LL8RF
UT WOS:000531821000083
PM 32244612
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Kitagawa, A
   Ohta, Y
   Ohashi, K
AF Kitagawa, Akira
   Ohta, Yoshiji
   Ohashi, Koji
TI Melatonin improves metabolic syndrome induced by high fructose intake in
   rats
SO JOURNAL OF PINEAL RESEARCH
LA English
DT Article
DE dyslipidemia; High fructose feeding (rat); hyperuricemia; insulin
   resistance; melatonin; metabolic syndrome; oxidative stress
ID INSULIN-RESISTANCE; OXIDATIVE STRESS; ADIPOSE-TISSUE; SWEETENED
   BEVERAGES; WEIGHT-GAIN; URIC-ACID; SENSITIVITY; ADIPONECTIN;
   CONSUMPTION; GLUCOSE
AB In this study, we examined whether melatonin improves metabolic syndrome induced by high fructose intake in male Wistar rats. Feeding of a diet containing 60% fructose (HFD) for 4 or 6 wk caused increased serum insulin, triglyceride, total cholesterol, free fatty acids, uric acid, leptin, and lipid peroxide concentrations as well as hepatic triglyceride and cholesterol concentrations, and relative intra-abdominal fat and liver weights. The 4- or 6-wk HFD feeding reduced serum high-density lipoprotein cholesterol and adiponectin concentrations. The 6-wk HFD feeding increased serum tumor necrosis factor-a concentration and hepatic lipid peroxide concentration and lowered hepatic reduced glutathione concentration. Daily intraperitoneal administration of melatonin (1 or 10 mg/kg body weight), starting at 4-wk HFD feeding, attenuated these changes at 6-wk HFD feeding more effectively at its higher dose than at its lower dose. In an oral glucose tolerance test, rats with 4- or 6-wk HFD feeding showed higher serum insulin response curve and normal serum glucose response curve when compared with the corresponding animals that received the control diet. The 4- or 6-wk HFD feeding caused insulin resistance, judging from the scores of HOMR-IR and QUICKI, which are indices of insulin resistance. The daily administered melatonin (1 or 10 mg/kg body weight) ameliorated the higher serum insulin response curve in the oral glucose tolerance test and insulin resistance at 6-wk HFD feeding more effectively at its higher dose than at its lower dose. These results indicate that melatonin improves metabolic syndrome induced by high fructose intake in rats.
C1 [Ohta, Yoshiji] Fujita Hlth Univ, Sch Med, Dept Chem, Toyoake, Aichi 4701192, Japan.
   [Kitagawa, Akira] Shigakkan Univ, Fac Wellness, Dept Nutr, Obu, Japan.
   [Ohashi, Koji] Fujita Hlth Univ, Sch Hlth Sci, Fac Med Technol, Dept Clin Biochem, Toyoake, Aichi 4701192, Japan.
C3 Fujita Health University; Fujita Health University
RP Ohta, Y (corresponding author), Fujita Hlth Univ, Sch Med, Dept Chem, Toyoake, Aichi 4701192, Japan.
EM yohta@fujita-hu.ac.jp
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NR 57
TC 90
Z9 96
U1 1
U2 25
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0742-3098
EI 1600-079X
J9 J PINEAL RES
JI J. Pineal Res.
PD MAY
PY 2012
VL 52
IS 4
BP 403
EP 413
DI 10.1111/j.1600-079X.2011.00955.x
PG 11
WC Endocrinology & Metabolism; Neurosciences; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Physiology
GA 923HU
UT WOS:000302611200005
PM 22220562
DA 2025-06-11
ER

PT J
AU López-Moreno, J
   García-Carpintero, S
   Jimenez-Lucena, R
   Haro, C
   Rangel-Zúñiga, OA
   Blanco-Rojo, R
   Yubero-Serrano, EM
   Tinahones, FJ
   Delgado-Lista, J
   Pérez-Martínez, P
   Roche, HM
   López-Miranda, J
   Camargo, A
AF Lopez-Moreno, Javier
   Garcia-Carpintero, Sonia
   Jimenez-Lucena, Rosa
   Haro, Carmen
   Rangel-Zuniga, Oriol A.
   Blanco-Rojo, Ruth
   Yubero-Serrano, Elena M.
   Tinahones, Francisco J.
   Delgado-Lista, Javier
   Perez-Martinez, Pablo
   Roche, Helen M.
   Lopez-Miranda, Jose
   Camargo, Antonio
TI Effect of Dietary Lipids on Endotoxemia Influences Postprandial
   Inflammatory Response
SO JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
LA English
DT Article
DE dietary fat; endotoxemia; inflammation; Lipgene; metabolic syndrome
ID ENDOPLASMIC-RETICULUM STRESS; METABOLIC SYNDROME PATIENTS;
   ADIPOSE-TISSUE; SYSTEMIC INFLAMMATION; TRANSCRIPTION FACTOR; INSULIN
   SENSITIVITY; MONONUCLEAR-CELLS; FAT MODIFICATION; OLIVE OIL; OBESITY
AB Metabolic syndrome (MetS) results in postprandial metabolic alterations that predisposes one to a state of chronic low-grade inflammation and increased oxidative stress. We aimed to assess the effect of the consumption of the quantity and quality of dietary fat on fasting and postprandial plasma lipopolysaccharides (LPS). A subgroup of 75 subjects with metabolic syndrome was randomized to receive 1 of 4 diets: HSFA, rich in saturated fat; HMUFA, rich in monounsaturated fat; LFHCC n-3, low-fat, rich in complex carbohydrate diet supplemented with n-3 polyunsaturated fatty acids; LFHCC low-fat, rich in complex carbohydrate diet supplemented with placebo, for 12 weeks each. We administered a fat challenge reflecting the fatty acid composition of the diets at postintervention. We determined the plasma lipoproteins and glucose and gene expression in peripheral blood mononuclear cells (PBMC) and adipose tissue. LPS and LPS binding protein (LBP) plasma levels were determined by ELISA, at fasting and postprandial (4 h after a fat challenge) states. We observed a postprandial increase in LPS levels after the intake of the HSFA meal, whereas we did not find any postprandial changes after the intake of the other three diets. Moreover, we found a positive relationship between the LPS plasma levels and the gene expression of IkBa and MIF1 in PBMC. No statistically significant differences in the LBP plasma levels at fasting or postprandial states were observed. Our results suggest that the consumption of HSFA diet increases the intestinal absorption of LPS which, in turn, increases postprandial endotoxemia levels and the postprandial inflammatory response.
C1 [Lopez-Moreno, Javier; Garcia-Carpintero, Sonia; Jimenez-Lucena, Rosa; Haro, Carmen; Rangel-Zuniga, Oriol A.; Blanco-Rojo, Ruth; Yubero-Serrano, Elena M.; Delgado-Lista, Javier; Perez-Martinez, Pablo; Lopez-Miranda, Jose; Camargo, Antonio] Univ Cordoba, Reina Sofia Univ Hosp, Maimonides Biomed Res Inst Cordoba IMIBIC, Lipids & Atherosclerosis Res Unit, Cordoba 14004, Spain.
   [Lopez-Moreno, Javier; Garcia-Carpintero, Sonia; Jimenez-Lucena, Rosa; Haro, Carmen; Rangel-Zuniga, Oriol A.; Blanco-Rojo, Ruth; Yubero-Serrano, Elena M.; Tinahones, Francisco J.; Delgado-Lista, Javier; Perez-Martinez, Pablo; Lopez-Miranda, Jose; Camargo, Antonio] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr CIBEROBN, Cordoba 14004, Spain.
   [Tinahones, Francisco J.] Hosp Virgen de la Victoria, Endocrinol & Nutr Serv, Malaga 29010, Spain.
   [Roche, Helen M.] Univ Coll Dublin, Sch Publ Hlth & Populat Sci, UCD Conway Inst, UCD Inst Food & Hlth, Dublin 4, Ireland.
C3 Universidad de Cordoba; Instituto de Salud Carlos III; CIBER - Centro de
   Investigacion Biomedica en Red; CIBEROBN; University College Dublin
RP López-Miranda, J; Camargo, A (corresponding author), Univ Cordoba, Reina Sofia Univ Hosp, Maimonides Biomed Res Inst Cordoba IMIBIC, Lipids & Atherosclerosis Res Unit, Cordoba 14004, Spain.; López-Miranda, J; Camargo, A (corresponding author), Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr CIBEROBN, Cordoba 14004, Spain.
EM jlopezmir@uco.es; antonio.camargo@imibic.org
RI Lopez-Miranda, Jose/Y-8306-2019; Roche, Helen/AAF-4164-2019; Tinahones,
   Francisco/AAB-2882-2020; Garcia Carpintero, Sonia/W-1261-2017; YUBERO,
   ELENA/AFM-2738-2022; Delgado-Lista, Javier/KAM-7412-2024; HARO,
   CARMEN/P-3104-2016; Camargo Garcia, Antonio/G-9720-2015; Perez Martinez,
   Pablo/AEL-6176-2022
OI HARO, CARMEN/0000-0002-1355-8359; Lopez-Miranda,
   Jose/0000-0002-8844-0718; Camargo Garcia, Antonio/0000-0002-0415-4184;
   Roche, Helen/0000-0002-0628-3318; Garcia Carpintero Fernandez Pacheco,
   Sonia/0000-0003-3403-3209; Delgado Lista, Francisco
   Javier/0000-0002-2982-2716; Jimenez-Lucena, Rosa/0000-0001-7115-3117;
   Tinahones, Francisco J/0000-0001-6871-4403; Rangel-Zuniga, Oriol
   Alberto/0000-0003-3495-5705; Perez Martinez, Pablo/0000-0001-7716-8117;
   Yubero-Serrano, Elena M/0000-0002-2733-5359
FU European Union [505944]; Ministerio de Ciencia e Innovacion
   [AGL2009-122270]; Ministerio de Economia y Competitividad
   [AGL2012/39615, PIE14/00005, PIE 14/00031, AGL2015-67896-P, FIS
   PI10/01041, FIS PI13/00023]; Consejeria de Salud, Junta de Andalucia
   [PI0193/09, PI-0252/09, PI-0058/10]; Consejeria de Innovacion Ciencia y
   Empresa [CVI-7450]; Fondo Europeo de Desarrollo Regional (FEDER); ISCIII
   [CP14/00114]
FX This work was supported in part by Research Grants from the European
   Union [LIPGENE European Integrated Project 505944]. It was also partly
   supported by research grants from the Ministerio de Ciencia e Innovacion
   (AGL2009-122270 to J.L.-M.); Ministerio de Economia y Competitividad
   (AGL2012/39615, PIE14/00005, PIE 14/00031 to J.L.-M., AGL2015-67896-P to
   J.L.-M. and A.C., FIS PI10/01041 to P.P.-M., FIS PI13/00023 to J.D.-L.);
   Consejeria de Salud, Junta de Andalucia (PI0193/09 to J.L.-M.),
   PI-0252/09 to J.D.-L., and PI-0058/10 to P.P.-M.; Consejeria de
   Innovacion Ciencia y Empresa (CVI-7450 to J.L.-M.); Fondo Europeo de
   Desarrollo Regional (FEDER). Antonio Camargo is supported by an ISCIII
   research contract (Programa Miguel-Servet CP14/00114).
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NR 52
TC 33
Z9 34
U1 0
U2 19
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0021-8561
EI 1520-5118
J9 J AGR FOOD CHEM
JI J. Agric. Food Chem.
PD SEP 6
PY 2017
VL 65
IS 35
BP 7756
EP 7763
DI 10.1021/acs.jafc.7b01909
PG 10
WC Agriculture, Multidisciplinary; Chemistry, Applied; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture; Chemistry; Food Science & Technology
GA FG4SI
UT WOS:000410255400019
PM 28793772
DA 2025-06-11
ER

PT J
AU Guerra-Ojeda, S
   Marchio, P
   Gimeno-Raga, M
   Arias-Mutis, OJ
   San-Miguel, T
   Valles, S
   Aldasoro, M
   Vila, JM
   Zarzoso, M
   Mauricio, MD
AF Guerra-Ojeda, Sol
   Marchio, Patricia
   Gimeno-Raga, Marc
   Julian Arias-Mutis, Oscar
   San-Miguel, Teresa
   Valles, Soraya
   Aldasoro, Martin
   Vila, Jose M.
   Zarzoso, Manuel
   Mauricio, Maria D.
TI PPARγ as an indicator of vascular function in an experimental model of
   metabolic syndrome in rabbits
SO ATHEROSCLEROSIS
LA English
DT Article
DE Metabolic syndrome; PPAR gamma; Akt; eNOS; Vascular dysfunction;
   Vascular oxidative stress
ID ACTIVATED-RECEPTOR-GAMMA; NITRIC-OXIDE; ENDOTHELIAL DYSFUNCTION;
   OXIDATIVE STRESS; RAT; PHOSPHORYLATION; TELMISARTAN; MECHANISM; ENOS
AB Background and aims: Underlying mechanisms associated with vascular dysfunction in metabolic syndrome (MetS) remain unclear and can even vary from one vascular bed to another.
   Methods: In this study, MetS was induced by a high-fat, high-sucrose diet, and after 28 weeks, aorta and renal arteries were removed and used for isometric recording of tension in organ baths, protein expression by Western blot, and histological analysis to assess the presence of atherosclerosis.
   Results: MetS induced a mild hypertension, pre-diabetes, central obesity and dyslipidaemia. Our results indicated that MetS did not change the contractile response in either the aorta or renal artery. Conversely, vasodilation was affected in both arteries in a different way. The aorta from MetS showed vascular dysfunction, including lower response to acetylcholine and sodium nitroprusside, while the renal artery from MetS presented a preserved relaxation to acetylcholine and an increased sensitivity to sodium nitroprusside. We did not find vascular oxidative stress in the aorta from MetS, but we found a significant decrease in PPAR gamma, phospho-Akt (p-Akt) and phospho-eNOS (p-eNOS) protein expression. On the other hand, we found oxidative stress in the renal artery from MetS, and PPAR gamma, Akt and p-Akt were overexpressed. No evidence of atherosclerosis was found in arteries from MetS.
   Conclusions: MetS affects vascular function differently depending on the vessel. In the aorta, it decreases both the vasodilation and the expression of the PPAR gamma/Akt/eNOS pathway, while in the renal artery, it increases the expression of PPAR gamma/Akt signalling pathway without decreasing the vasodilation.
C1 [Guerra-Ojeda, Sol; Marchio, Patricia; Gimeno-Raga, Marc; Julian Arias-Mutis, Oscar; Valles, Soraya; Aldasoro, Martin; Vila, Jose M.; Mauricio, Maria D.] Univ Valencia, Sch Med, Dept Physiol, Blasco Ibanez 15, Valencia 46010, Spain.
   [Guerra-Ojeda, Sol; Marchio, Patricia; Gimeno-Raga, Marc; Julian Arias-Mutis, Oscar; Valles, Soraya; Aldasoro, Martin; Vila, Jose M.; Mauricio, Maria D.] Inst Hlth Res INCLIVA, Valencia, Spain.
   [San-Miguel, Teresa] Univ Valencia, Dept Pathol, Sch Med, Valencia, Spain.
   [Zarzoso, Manuel] Univ Valencia, Dept Physiotherapy, Sch Physiotherapy, Valencia, Spain.
C3 University of Valencia; University of Valencia; University of Valencia
RP Mauricio, MD (corresponding author), Univ Valencia, Sch Med, Dept Physiol, Blasco Ibanez 15, Valencia 46010, Spain.
EM m.dolores.mauricio@uv.es
RI Arias-Mutis, Oscar/AAA-5858-2019; Guerra, Solanye/AAX-2891-2021;
   ALDASORO, MARTIN/AAB-3344-2019; VILA, JOSE/L-4199-2014; Mauricio,
   Maria/AAN-7412-2020; Zarzoso, Manuel/AAA-6129-2019; San-Miguel,
   Teresa/D-7784-2018
OI San-Miguel, Teresa/0000-0003-1892-6285; Guerra,
   Solanye/0000-0003-3018-4683; Zarzoso, Manuel/0000-0003-3372-4497; Vila
   Salinas/0000-0001-8589-9307; Mauricio, Maria D/0000-0002-7695-2898
FU Generalitat Valenciana [PROMETEO/2018/078, GV2015-062]; Instituto de
   Salud Carlos III [CB16/11/00486]; Universitat de Val`encia: Financament
   d'accions especials d'investigacio [UV-INV-AE19-1212749,
   UV-INV-AE-1544052]
FX Generalitat Valenciana (PROMETEO/2018/078, GV2015-062), Instituto de
   Salud Carlos III (CB16/11/00486) and Universitat de Val`encia:
   Financament d'accions especials d'investigacio. Expedient:
   UV-INV-AE19-1212749 and Expedient: UV-INV-AE-1544052.
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NR 28
TC 2
Z9 2
U1 0
U2 6
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0021-9150
EI 1879-1484
J9 ATHEROSCLEROSIS
JI Atherosclerosis
PD SEP
PY 2021
VL 332
BP 16
EP 23
DI 10.1016/j.atherosclerosis.2021.08.006
EA AUG 2021
PG 8
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA UM4VD
UT WOS:000693328700002
PM 34375909
OA hybrid
DA 2025-06-11
ER

PT J
AU Costa, NT
   Scavuzzi, BM
   Iriyoda, TMV
   Lozovoy, MAB
   Alfieri, D
   de Medeiros, FA
   de Sá, MC
   Micheletti, PL
   Sekiguchi, BA
   Reiche, EMV
   Maes, M
   Simao, ANC
   Dichi, I
AF Costa, Neide Tomimura
   Scavuzzi, Bruna Miglioranza
   Veiga Iriyoda, Tatiana Mayumi
   Batisti Lozovoy, Marcell Alysson
   Alfieri, Daniela Frizon
   de Medeiros, Fabiano Aparecido
   de Sa, Marcelo Candido
   Micheletti, Pamela Lonardoni
   Sekiguchi, Bruno Alexandre
   Vissoci Reiche, Edna Maria
   Maes, Michael
   Colado Simao, Andrea Name
   Dichi, Isaias
TI Metabolic syndrome and the decreased levels of uric acid by leflunomide
   favor redox imbalance in patients with rheumatoid arthritis
SO CLINICAL AND EXPERIMENTAL MEDICINE
LA English
DT Article
DE Rheumatoid arthritis; Oxidative stress; Nitrosative stress; Metabolic
   syndrome; Leflunomide
ID NITRIC-OXIDE PRODUCTION; OXIDATION PROTEIN PRODUCTS; LIPID-PEROXIDATION;
   ANTIOXIDANT STATUS; BIOLOGICAL-FLUIDS; REACTIVE OXYGEN; SYNOVIAL-FLUID;
   STRESS; DAMAGE; BLOOD
AB Oxidative stress plays a role in the pathophysiology of rheumatoid arthritis (RA). The aim of the present study was to verify the influence of metabolic syndrome (MetS) and disease-modifying antirheumatic drugs on nitrosative and oxidative biomarkers in patients with RA. A total of 177 patients with RA and 150 healthy volunteers participated in this study, which measured lipid hydroperoxides, advanced oxidation protein products (AOPP), nitric oxide metabolites (NOx), carbonyl protein, total radical-trapping antioxidant parameter (TRAP), uric acid (UA), and C-reactive protein (CRP). NOx and the NOx/TRAP ratio were significantly increased in RA, while no significant differences in lipid hydroperoxides, AOPP, UA, and TRAP levels were found between both groups. Treatment with leflunomide was associated with increased levels of carbonyl protein, and lowered levels in TRAP and UA, while the NOx/TRAP ratio further increased. NOx and the NOx/TRAP ratio were significantly higher in women than in men, while TRAP and UA were significantly lower in women. MetS was accompanied by increased AOPP and UA levels. RA was best predicted by increased NOx/TRAP ratio, CRP, and BMI. In conclusion, our data demonstrated that NOx and NOx/TRAP are strongly associated with RA physiopathology. Our findings suggest that inhibition of iNOS may become an interesting therapeutic approach for the treatment of RA. In addition, the presence of MetS and a decrease in levels of UA by leflunomide favor redox imbalance in RA patients. More studies are needed to evaluate the impact of antioxidant capacity reduction on RA progression.
C1 [Costa, Neide Tomimura; Scavuzzi, Bruna Miglioranza; Alfieri, Daniela Frizon; Sekiguchi, Bruno Alexandre] Univ Londrina, Lab Res Appl Immunol, Londrina, Parana, Brazil.
   [Costa, Neide Tomimura; Dichi, Isaias] Univ Londrina, Dept Internal Med, Londrina, Parana, Brazil.
   [Veiga Iriyoda, Tatiana Mayumi] PUC, Dept Rheumatol, Londrina, Parana, Brazil.
   [Batisti Lozovoy, Marcell Alysson; Vissoci Reiche, Edna Maria; Colado Simao, Andrea Name] Univ Londrina, Dept Clin Pathol Clin Anal & Toxicol, Robert Koch Ave 60 Bairro Cervejaria, BR-86038440 Londrina, Parana, Brazil.
   [de Medeiros, Fabiano Aparecido; de Sa, Marcelo Candido; Micheletti, Pamela Lonardoni] Univ Londrina, Post Grad Program Clin & Lab Pathophysiol, Londrina, Parana, Brazil.
   [Maes, Michael] Deakin Univ, Sch Med, IMPACT Strateg Res Ctr, Geelong, Vic, Australia.
C3 Deakin University
RP Simao, ANC (corresponding author), Univ Londrina, Dept Clin Pathol Clin Anal & Toxicol, Robert Koch Ave 60 Bairro Cervejaria, BR-86038440 Londrina, Parana, Brazil.
EM deianame@yahoo.com.br
RI Costa, Neide/KFQ-1766-2024; Simão, Andrea/AAM-4892-2021; de Sá,
   Marcelo/AAK-9551-2020; Scavuzzi, Bruna/AAK-7916-2020; Lozovoy,
   Marcell/AAM-4897-2021; Maes, Michael/B-8546-2011; Reiche,
   EDNa/AAD-4186-2020; Reiche, Edna Maria Vissoci/C-4102-2013
OI Candido de Sa, Marcelo/0000-0003-0168-569X; Maes,
   Michael/0000-0002-2012-871X; Reiche, Edna Maria
   Vissoci/0000-0001-6507-2839; Miglioranza Scavuzzi,
   Bruna/0000-0001-9609-001X
FU Coordination for the Improvement of Higher Level of Education Personnel
   (CAPES) of Brazilian Ministry of Education; Institutional Program for
   Scientific Initiation Scholarship (PIBIC) of the National Council for
   Scientific and Technological Development (CNPq); State University of
   Londrina (PROPPG)
FX The study was supported by Grants from Coordination for the Improvement
   of Higher Level of Education Personnel (CAPES) of Brazilian Ministry of
   Education; Institutional Program for Scientific Initiation Scholarship
   (PIBIC) of the National Council for Scientific and Technological
   Development (CNPq); and State University of Londrina (PROPPG). We thank
   the University Hospital of State University of Londrina for technical
   supports.
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NR 73
TC 10
Z9 10
U1 1
U2 7
PU SPRINGER-VERLAG ITALIA SRL
PI MILAN
PA VIA DECEMBRIO, 28, MILAN, 20137, ITALY
SN 1591-8890
EI 1591-9528
J9 CLIN EXP MED
JI Clin. Exper. Med.
PD AUG
PY 2018
VL 18
IS 3
BP 363
EP 372
DI 10.1007/s10238-018-0500-y
PG 10
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA GN5YU
UT WOS:000439146200007
PM 29644482
DA 2025-06-11
ER

PT J
AU Barbano, MF
   Castañé, A
   Martín-García, E
   Maldonado, R
AF Flavia Barbano, Maria
   Castane, Anna
   Martin-Garcia, Elena
   Maldonado, Rafael
TI Delta-9-tetrahydrocannabinol enhances food reinforcement in a mouse
   operant conflict test
SO PSYCHOPHARMACOLOGY
LA English
DT Article
DE Food reinforcement; THC; Operant behavior; Foot-shock; Palatability;
   Stress; Mice
ID ENDOGENOUS CANNABINOID SYSTEM; CARDIOMETABOLIC RISK-FACTORS; CB1
   RECEPTOR ANTAGONIST; ANXIETY-LIKE BEHAVIOR; MOLECULAR CHARACTERIZATION;
   PALATABLE FOOD; D-AMPHETAMINE; MILD STRESS; LEWIS RATS; RIMONABANT
AB Cannabinoid compounds are known to regulate feeding behavior by modulating the hedonic and/or the incentive properties of food.
   The aim of this work was to determine the involvement of the cannabinoid system in food reinforcement associated with a conflict situation generated by stress.
   Mice were trained on a fixed ratio 1 schedule of reinforcement to obtain standard, chocolate-flavored or fat-enriched pellets. Once the acquisition criteria were achieved, the reinforced lever press was paired with foot-shock exposure, and the effects of Delta(9)-tetrahydrocannabinol (THC; 1 mg/kg) were evaluated in this conflict paradigm.
   THC did not modify the operant response in mice trained with standard pellets. In contrast, THC improved the instrumental performance of mice trained with chocolate-flavored and fat-enriched pellets. However, the cannabinoid agonist did not fully restore the baseline responses obtained previous to foot-shock delivery. THC ameliorated the performance to obtain high palatable food in this conflict test in both food-restricted and sated mice. The effects of THC on food reinforcement seem to be long-lasting since mice previously treated with this compound showed a better recovery of the instrumental behavior after foot-shock exposure.
   These findings reveal that the cannabinoid system is involved in the regulation of goal-directed responses towards high palatable and high caloric food under stressful situations.
C1 [Flavia Barbano, Maria; Castane, Anna; Martin-Garcia, Elena; Maldonado, Rafael] Univ Pompeu Fabra, Dept Ciencies Expt & Salut, PRBB, Barcelona 08003, Spain.
C3 Pompeu Fabra University; Barcelona Biomedical Research Park
RP Maldonado, R (corresponding author), Univ Pompeu Fabra, Dept Ciencies Expt & Salut, PRBB, C Dr Aiguader 88, Barcelona 08003, Spain.
EM rafael.maldonado@upf.edu
RI Castañé, Anna/AAB-5005-2020; Maldonado, Rafael/F-5657-2014; Castane,
   Anna/K-2201-2014; Martin-Garcia, Elena/H-5406-2013
OI Castane, Anna/0000-0002-2578-445X; Martin-Garcia,
   Elena/0000-0002-4487-3028
FU US National Institutes of Health-National Institute of Drug Abuse
   (NIH-NIDA) [5R01-DA016768]; Spanish "Ministerio de Educacion y Ciencia"
   [SAF2007-64062]; DG Research of the European Commission
   [LSHM-CT-2004-05166]; PHECOMP [LSHM-CT-2007-037669]; Generalitat de
   Catalunya-DURSI [2005SGR00131]; Spanish "Instituto de Salud Carlos III"
   [RD06/001/001]; Spanish "Instituto de Salud Carlos III"
FX This work was supported by the US National Institutes of Health-National
   Institute of Drug Abuse (NIH-NIDA) (no. 5R01-DA016768), the Spanish
   "Ministerio de Educacion y Ciencia" (no. SAF2007-64062), the DG Research
   of the European Commission (GEN-ADDICT, no. LSHM-CT-2004-05166; and
   PHECOMP, no. LSHM-CT-2007-037669), the "Generalitat de Catalunya-DURSI"
   (# 2005SGR00131 and ICREA Academia) and the Spanish "Instituto de Salud
   Carlos III" (no. RD06/001/001). M. F. B. was supported by a
   post-doctoral fellowship from Fyssen Foundation. E. M. G. was supported
   by a post-doctoral fellowship from the Spanish "Instituto de Salud
   Carlos III". We thank Dr. Patricia Robledo for stylistic revision of the
   manuscript.
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NR 60
TC 16
Z9 18
U1 0
U2 5
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0033-3158
EI 1432-2072
J9 PSYCHOPHARMACOLOGY
JI Psychopharmacology
PD AUG
PY 2009
VL 205
IS 3
BP 475
EP 487
DI 10.1007/s00213-009-1557-9
PG 13
WC Neurosciences; Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA 472HE
UT WOS:000268120400012
PM 19452141
DA 2025-06-11
ER

PT J
AU Londero, AS
   Arana, MR
   Perdomo, VG
   Tocchetti, GN
   Zecchinati, F
   Ghanem, CI
   Ruiz, ML
   Rigalli, JP
   Mottino, AD
   García, F
   Villanueva, SSM
AF Sofia Londero, Ana
   Rocio Arana, Maite
   Gabriela Perdomo, Virginia
   Nicolas Tocchetti, Guillermo
   Zecchinati, Felipe
   Ines Ghanem, Carolina
   Laura Ruiz, Maria
   Rigalli, Juan Pablo
   Domingo Mottino, Aldo
   Garcia, Fabiana
   Maris Villanueva, Silvina Stella
TI Intestinal multidrug resistance-associated protein 2 is down-regulated
   in fructose-fed rats
SO JOURNAL OF NUTRITIONAL BIOCHEMISTRY
LA English
DT Article
DE Fructose-rich diet; Metabolic syndrome; Insulin resistance; Intestine;
   Mrp2; GST
ID METABOLIC-SYNDROME; INSULIN-RESISTANCE; SUPEROXIDE-DISMUTASE; EFFLUX
   TRANSPORTERS; OXIDATIVE STRESS; PUMP MRP2; RICH DIET; EXPRESSION;
   GLUTATHIONE; LIVER
AB Expression and activity of jejunal multidrug resistance-associated protein 2 (Mrp2) and glutathione-S-transferase (GST) were examined in fructose fed Wistar rats, an experimental model of metabolic syndrome. Animals were fed on (a) control diet or (b) control diet plus 10% w/vol fructose in the drinking water. Mrp2 and the a class of GST proteins as well as their corresponding mRNAs were decreased, suggesting a transcriptional regulation by fructose. Confocal microscopy studies reaffirmed down-regulation of Mrp2. Everted intestinal sacs were incubated with 1-chloro-2,4-dinitrobenzene in the mucosal compartment, and the glutathione-conjugated derivative, dinitrophenyl- S-glutathione (DNP-SG; model Mrp2 substrate), was measured in the same compartment to estimate Mrp2 activity. Excretion of DNP-SG was substantially decreased by fructose treatment, consistent with simultaneous down-regulation of Mrp2 and GST. In addition, the effect of fructose on intestinal barrier function exerted by Mrp2 was evaluated in vivo using valsartan, a recognized Mrp2 substrate of therapeutic use. After intraduodenal administration as a bolus, intestinal absorption of valsartan was increased in fructose-drinking animals. Fructose administration also induced oxidative stress in intestinal tissue as demonstrated by significant increases of intestinal lipid peroxidation end products and activity of the antioxidant enzyme superoxide dismutase, by a decreased GSH/GSSG ratio. Moreover, fructose treatment conduced to increased intestinal levels of the proinflammatory cytokines IL-beta 1 and IL-6.
   Collectively, our results demonstrate that metabolic syndrome-like conditions, induced by a fructose-rich diet, result in down-regulation of intestinal Mrp2 expression and activity and consequently in an impairment of its barrier function. (C) 2016 Elsevier Inc. All rights reserved.
C1 [Sofia Londero, Ana; Rocio Arana, Maite; Nicolas Tocchetti, Guillermo; Zecchinati, Felipe; Laura Ruiz, Maria; Domingo Mottino, Aldo; Maris Villanueva, Silvina Stella] Univ Nacl Rosario, Fac Ciencias Bioquim & Farmaceut, IFISE CONICET, Inst Fisiol Expt, Rosario, Santa Fe, Argentina.
   [Gabriela Perdomo, Virginia] Univ Nacl Rosario, Fac Ciencias Bioquim & Farmaceut, IBR CONICET, Inst Biol Mol & Celular Rosario, Rosario, Santa Fe, Argentina.
   [Ines Ghanem, Carolina] Univ Buenos Aires, Fac Farm & Bioquim, ININFA CONICET, Inst Invest Farrnacol, Ciudad Autonoma, Buenos Aires, DF, Argentina.
   [Garcia, Fabiana] Univ Nacl Rosario, Fac Ciencias Med, CONICET, Catedra Fisiol Humana, Rosario, Santa Fe, Argentina.
   [Rigalli, Juan Pablo] Heidelberg Univ, Dept Clin Pharmacol & Pharmacoepidemiol, Heidelberg, Germany.
C3 National University of Rosario; Consejo Nacional de Investigaciones
   Cientificas y Tecnicas (CONICET); Consejo Nacional de Investigaciones
   Cientificas y Tecnicas (CONICET); National University of Rosario;
   University of Buenos Aires; Consejo Nacional de Investigaciones
   Cientificas y Tecnicas (CONICET); National University of Rosario;
   Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET);
   Ruprecht Karls University Heidelberg
RP Villanueva, SSM (corresponding author), UNR, Fac Ciencias Bioquim & Farmaceut, CONICET, Inst Fisiol Expt, Suipacha 570, RA-2000 Rosario, Santa Fe, Argentina.
EM villanueva@ifise-conicet.gov.ar
RI Perdomo, Virginia/JMP-4098-2023; Rigalli, Juan Pablo/E-2099-2018
OI Perdomo, Virginia Gabriela/0009-0006-3087-7630; Rigalli, Juan
   Pablo/0000-0003-4168-9396; Tocchetti, Guillermo
   Nicolas/0000-0003-3884-0980; Ghanem, Carolina Ines/0000-0002-7426-459X
FU Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET)
   [PIP 2012-0240]; Fondo para la Investigacion Cientifica y Tecnologica
   (FONCyT) [PICT 2014-0476, PICT 2014-1121]
FX This study was supported by grants from: Consejo Nacional de
   Investigaciones Cientificas y Tecnicas (CONICET) [PIP 2012-0240 (to
   A.D.M.)], Fondo para la Investigacion Cientifica y Tecnologica (FONCyT)
   [PICT 2014-0476 (to A.D.M.) and PICT 2014-1121 (to S.S.M.V.)].
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NR 62
TC 17
Z9 17
U1 1
U2 9
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0955-2863
EI 1873-4847
J9 J NUTR BIOCHEM
JI J. Nutr. Biochem.
PD FEB
PY 2017
VL 40
BP 178
EP 186
DI 10.1016/j.jnutbio.2016.11.002
PG 9
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA EJ5KQ
UT WOS:000393257300021
PM 27915161
OA Green Published
DA 2025-06-11
ER

PT J
AU Ojala, JO
   Sutinen, EM
AF Ojala, Johanna O.
   Sutinen, Elina M.
TI The Role of Interleukin-18, Oxidative Stress and Metabolic Syndrome in
   Alzheimer's Disease
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Review
DE interleukin-18; inflammation; oxidative stress; Alzheimer's disease;
   metabolic syndrome; blood-brain barrier; BVR; DJ-1; DDAH; peroxiredoxin;
   enolase; 14-3-3; MMP14; Bcl-xL
ID INFERIOR PARIETAL LOBULE; BILIVERDIN REDUCTASE; MATRIX
   METALLOPROTEINASES; GENE-EXPRESSION; GAMMA-ENOLASE; LIFE-STYLE;
   ASYMMETRIC DIMETHYLARGININE; INDOLEAMINE 2,3-DIOXYGENASE; PROTEOMIC
   IDENTIFICATION; COGNITIVE IMPAIRMENT
AB The role of interleukins (ILs) and oxidative stress (OS) in precipitating neurodegenerative diseases including sporadic Alzheimer's disease (AD), requires further clarification. In addition to neuropathological hallmarks-extracellular neuritic amyloid-beta (alpha beta) plaques, neurofibrillary tangles (NFT) containing hyperphosphorylated tau and neuronal loss-chronic inflammation, as well as oxidative and excitotoxic damage, are present in the AD brain. The pathological sequelae and the interaction of these events during the course of AD need further investigation. The brain is particularly sensitive to OS, due to the richness of its peroxidation-sensitive fatty acids, coupled with its high oxygen demand. At the same time, the brain lack robust antioxidant systems. Among the multiple mechanisms and triggers by which OS can accumulate, inflammatory cytokines can sustain oxidative and nitrosative stress, leading eventually to cellular damage. Understanding the consequences of inflammation and OS may clarify the initial events underlying AD, including in interaction with genetic factors. Inflammatory cytokines are potential inducers of aberrant gene expression through transcription factors. Susceptibility disorders for AD, including obesity, type-2 diabetes, cardiovascular diseases and metabolic syndrome have been linked to increases in the proinflammatory cytokine, IL-18, which also regulates multiple AD related proteins. The association of IL-18 with AD and AD-linked medical conditions are reviewed in the article. Such data indicates that an active lifestyle, coupled to a healthy diet can ameliorate inflammation and reduce the risk of sporadic AD.
C1 [Ojala, Johanna O.; Sutinen, Elina M.] Univ Eastern Finland, Inst Clin Med, Neurol, POB 1627, FI-70211 Kuopio, Finland.
C3 University of Eastern Finland
RP Ojala, JO (corresponding author), Univ Eastern Finland, Inst Clin Med, Neurol, POB 1627, FI-70211 Kuopio, Finland.
EM johanna.ojala@uef.fi; elina.siira@uef.fi
OI Ojala, Johanna/0000-0002-8528-1387
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NR 163
TC 50
Z9 54
U1 0
U2 16
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD MAY
PY 2017
VL 6
IS 5
AR 55
DI 10.3390/jcm6050055
PG 23
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA EZ0IV
UT WOS:000404387500008
PM 28531131
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Mauss, D
   Litaker, D
   Jarczok, MN
   Li, J
   Bosch, JA
   Fischer, JE
AF Mauss, Daniel
   Litaker, David
   Jarczok, Marc N.
   Li, Jian
   Bosch, Jos A.
   Fischer, Joachim E.
TI Anti-clockwise rotating shift work and health: Would you prefer 3-shift
   or 4-shift operation?
SO AMERICAN JOURNAL OF INDUSTRIAL MEDICINE
LA English
DT Article
DE heart rate variability; metabolic syndrome; nightshift; sleep quality;
   work-related stress
ID EFFORT-REWARD IMBALANCE; HEART-RATE-VARIABILITY; METABOLIC SYNDROME;
   NIGHT-SHIFT; MYOCARDIAL-INFARCTION; SLEEP QUALITY; RISK-FACTORS;
   ASSOCIATION; COUNTRIES; INDUSTRY
AB Background We explored the association between work schedules involving nightshifts and selected measures of health and whether these associations differed among those working in either 3- or 4-shift cycles. Methods Employees at a German industrial company who worked on a fixed daytime schedule or on one involving nightshifts were invited to participate in this cross-sectional study. Work schedules involving a nightshift were organized into either 3 or 4 shifts rotated anti-clockwise on a weekly basis. Health characteristics included a range of clinical and physiological measures and self-reported data on stress and sleep quality. We assessed the independent association of work schedules involving any nightshift and these health characteristics in separate regression analyses, adjusting for age, gender, smoking, and alcohol consumption. Results Nightshift work (N=133) in general and 3-shift-work (N=53) in particular was associated with decreased sleep quality (P<0.001). Compared to those working daytime (N=632), employees working on a 3-shift cycle had higher adjusted odds of meeting the definition of metabolic syndrome (OR=2.56 [1.38, 4.75]). Employees working 4-shift cycles were somewhat less likely to have metabolic syndrome (OR=1.22 [0.73, 2.05]) and had higher parasympathetic activity measured by heart rate variability (OR=2.20 [1.04, 4.63]). Conclusions Our data suggest important relationships between shift schedule and a selected group of objective and subjective health measures. Additional research that further clarifies potential mechanisms underlying these relationships is needed. Am. J. Ind. Med. 56:599608, 2013. (c) 2013 Wiley Periodicals, Inc.
C1 [Mauss, Daniel; Litaker, David; Jarczok, Marc N.; Bosch, Jos A.; Fischer, Joachim E.] Heidelberg Univ, Mannheim Inst Publ Hlth Social & Prevent Med, Mannheim Med Fac, D-68167 Mannheim, Germany.
   [Mauss, Daniel] Allianz Germany, Dept Occupat Med, Munich, Germany.
   [Litaker, David] Ohio Case Western Reserve Univ, Dept Epidemiol & Biostat, Cleveland, OH USA.
   [Li, Jian] Univ Dusseldorf, Inst Occupat & Social Med, D-40225 Dusseldorf, Germany.
   [Bosch, Jos A.] Univ Amsterdam, Fac Social & Behav Sci, NL-1012 WX Amsterdam, Netherlands.
   [Fischer, Joachim E.] Heidelberg Univ, Competence Ctr Social Med & Occupat Hlth Promot, D-68167 Mannheim, Germany.
C3 Ruprecht Karls University Heidelberg; Allianz SE; University System of
   Ohio; Case Western Reserve University; Heinrich Heine University
   Dusseldorf; University of Amsterdam; Ruprecht Karls University
   Heidelberg
RP Mauss, D (corresponding author), Heidelberg Univ, Mannheim Inst Publ Hlth Social & Prevent Med, Mannheim Med Fac, Ludolf Krehl Str 7-11, D-68167 Mannheim, Germany.
EM daniel.mauss@allianz.de
RI Bosch, Jos/AAC-9408-2019; Jarczok, Marc N./A-2383-2014
OI Litaker, David/0000-0003-2676-7990; Jarczok, Marc N./0000-0002-6055-385X
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NR 55
TC 18
Z9 20
U1 0
U2 17
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0271-3586
EI 1097-0274
J9 AM J IND MED
JI Am. J. Ind. Med.
PD MAY
PY 2013
VL 56
IS 5
BP 599
EP 608
DI 10.1002/ajim.22157
PG 10
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA 127GA
UT WOS:000317684400012
PM 23334903
DA 2025-06-11
ER

PT J
AU Lebda, MA
   Tohamy, HG
   El-Sayed, YS
AF Lebda, Mohamed A.
   Tohamy, Hossam G.
   El-Sayed, Yasser S.
TI Long-term soft drink and aspartame intake induces hepatic damage
   via dysregulation of adipocytokines and alteration of the lipid
   profile and antioxidant status
SO NUTRITION RESEARCH
LA English
DT Article
DE Sweetened beverages; Aspartame; Metabolic syndrome; Adipocytokines;
   Oxidative stress; Gene expression
ID FRUCTOSE CORN SYRUP; INDUCED METABOLIC SYNDROME; SUGAR-SWEETENED
   BEVERAGES; OXIDATIVE STRESS; INSULIN-RESISTANCE; COLA BEVERAGES;
   STELLATE CELLS; BODY-WEIGHT; RAT-LIVER; ADIPONECTIN
AB Dietary intake of fructose corn syrup in sweetened beverages is associated with the development of metabolic syndrome and obesity. We hypothesized that inflammatory cytokines play a role in lipid storage and induction of liver injury. Therefore, this study intended to explore the expression of adipocytokines and its link to hepatic damage. Rats were assigned to drink water, cola soft drink (free access) and aspartame (240 mg/kg body weight/day orally) for 2 months. The lipid profiles, liver antioxidants and pathology, and mRNA expression of adipogenic cytokines were evaluated. Subchronic intake of soft drink or aspartame substantially induced hyperglycemia and hypertriacylglycerolemia, as represented by increased serum glucose, triacylglycerol, low-density lipoprotein and very low-density lipoprotein cholesterol, with obvious visceral fatty deposition. These metabolic syndromes were associated with the up-regulation of leptin and down-regulation of adiponectin and peroxisome proliferator activated receptor-gamma (PPAR-gamma) expression. Moreover, alterations in serum transaminases accompanied by hepatic oxidative stress involving induction of malondialdehyde and reduction of superoxide dismutase, catalase, and glutathione peroxidase and glutathione levels are indicative of oxidative hepatic damage. Several cytoarchitecture alterations were detected in the liver, including degeneration, infiltration, necrosis, and fibrosis, predominantly with aspartame. These data suggest that long-term intake of soft drink or aspartame-induced hepatic damage may be mediated by the induction of hyperglycemia, lipid accumulation, and oxidative stress with the involvement of adipocytokines. (C) 2017 Elsevier Inc. All rights reserved.
C1 [Lebda, Mohamed A.] Univ Alexandria, Dept Biochem, Fac Vet Med, Edfina 22758, Egypt.
   [Tohamy, Hossam G.] Univ Alexandria, Dept Pathol, Fac Vet Med, Edfina 22758, Egypt.
   [El-Sayed, Yasser S.] Damanhour Univ, Dept Forens Med & Toxicol, Fac Vet Med, Damanhour 22511, Egypt.
C3 Egyptian Knowledge Bank (EKB); Alexandria University; Egyptian Knowledge
   Bank (EKB); Alexandria University; Egyptian Knowledge Bank (EKB);
   Damanhour University
RP Lebda, MA (corresponding author), Univ Alexandria, Dept Biochem, Fac Vet Med, Edfina 22758, Egypt.
EM mohamed.a.mohamed@alexu.edu.eg; hossam.gafar@yahoo.com;
   yasser_tf@yahoo.com
RI Lebda, Mohamed/S-9126-2018; Tohamy, Hossam/GLU-2413-2022; El-Sayed,
   Yasser/E-6400-2010
OI Tohamy, Hossam/0000-0002-7367-9654; El-Sayed, Yasser/0000-0003-3915-4640
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NR 50
TC 30
Z9 30
U1 6
U2 46
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0271-5317
J9 NUTR RES
JI Nutr. Res.
PD MAY
PY 2017
VL 41
BP 47
EP 55
DI 10.1016/j.nutres.2017.04.002
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA EX5SK
UT WOS:000403302600004
PM 28465000
DA 2025-06-11
ER

PT J
AU Ma, H
   Liu, J
   Bian, ZH
   Cui, YQ
   Zhou, XY
   Zhou, XF
   Zhang, B
   Adesanya, TMA
   Yi, F
   Park, KH
   Tan, T
   Chen, ZS
   Zhu, H
AF Ma, Hanley
   Liu, Jason
   Bian, Zehua
   Cui, Yuqi
   Zhou, Xinyu
   Zhou, Xuefeng
   Zhang, Bo
   Adesanya, T. M. Ayodele
   Yi, Frank
   Park, Ki Ho
   Tan, Tao
   Chen, Zhishui
   Zhu, Hua
TI Effect of Metabolic Syndrome on Mitsugumin 53 Expression and Function
SO PLOS ONE
LA English
DT Article
ID INSULIN-RESISTANCE; MEMBRANE REPAIR; MG53; DISRUPTION; INJURY;
   CARDIOPROTECTION; MICE
AB Metabolic syndrome is a cluster of risk factors, such as obesity, insulin resistance, and hyperlipidemia that increases the individual's likelihood of developing cardiovascular diseases. Patients inflicted with metabolic disorders also suffer from tissue repair defect. Mitsugumin 53 (MG53) is a protein essential to cellular membrane repair. It facilitates the nucleation of intracellular vesicles to sites of membrane disruption to create repair patches, contributing to the regenerative capacity of skeletal and cardiac muscle tissues upon injury. Since individuals suffering from metabolic syndrome possess tissue regeneration deficiency and MG53 plays a crucial role in restoring membrane integrity, we studied MG53 activity in mice models exhibiting metabolic disorders induced by a 6 month high-fat diet (HFD) feeding. Western blotting showed that MG53 expression is not altered within the skeletal and cardiac muscles of mice with metabolic syndrome. Rather, we found that MG53 levels in blood circulation were actually reduced. This data directly contradicts findings presented by Song et. al that indict MG53 as a causative factor for metabolic syndrome (Nature 494, 375-379). The diminished MG53 serum level observed may contribute to the inadequate tissue repair aptitude exhibited by diabetic patients. Furthermore, immunohistochemical analyses reveal that skeletal muscle fibers of mice with metabolic disorders experience localization of subcellular MG53 around mitochondria. This clustering may represent an adaptive response to oxidative stress resulting from HFD feeding and may implicate MG53 as a guardian to protect damaged mitochondria. Therapeutic approaches that elevate MG53 expression in serum circulation may be a novel method to treat the degenerative tissue repair function of diabetic patients.
C1 [Ma, Hanley; Liu, Jason; Bian, Zehua; Cui, Yuqi; Zhou, Xinyu; Zhou, Xuefeng; Zhang, Bo; Adesanya, T. M. Ayodele; Yi, Frank; Park, Ki Ho; Tan, Tao; Zhu, Hua] Ohio State Univ, Davis Heart & Lung Res Inst, Dept Surg, Columbus, OH 43210 USA.
   [Ma, Hanley] Olentangy Liberty High Sch, Powell, OH USA.
   [Liu, Jason] Dublin Jerome High Sch, Dublin, OH USA.
   [Zhang, Bo; Chen, Zhishui] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Inst Organ Transplantat, Wuhan 430074, Hubei, Peoples R China.
C3 University System of Ohio; Ohio State University; Huazhong University of
   Science & Technology
RP Zhu, H (corresponding author), Ohio State Univ, Davis Heart & Lung Res Inst, Dept Surg, Columbus, OH 43210 USA.
EM Hua.Zhu@osumc.edu
RI Cui, Yuqi/U-5914-2017; Zhang, Bo/Q-7605-2018; Zhou, Xinyu/JJE-4445-2023;
   Park, Ki Ho/N-8153-2017; zhu, hua/JRW-4010-2023
OI Zhu, Hua/0000-0001-7136-7326; Park, Ki Ho/0000-0002-6193-9826
FU American Heart Association [12SDG12070174]; American Heart Association
   (AHA) [12SDG12070174] Funding Source: American Heart Association (AHA)
FX Funding: The work was supported by American Heart Association
   (12SDG12070174 to HZ). The funders had no role in study design, data
   collection and analysis, decision to publish, or preparation of the
   manuscript.
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NR 26
TC 36
Z9 37
U1 0
U2 12
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAY 7
PY 2015
VL 10
IS 5
AR e0124128
DI 10.1371/journal.pone.0124128
PG 10
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA CH7KF
UT WOS:000354214400011
PM 25950605
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Reynolds, RM
   Fischbacher, C
   Bhopal, R
   Byrne, CD
   White, M
   Unwin, N
   Walker, BR
AF Reynolds, RM
   Fischbacher, C
   Bhopal, R
   Byrne, CD
   White, M
   Unwin, N
   Walker, BR
TI Differences in cortisol concentrations in South Asian and European men
   living in the United Kingdom
SO CLINICAL ENDOCRINOLOGY
LA English
DT Article
ID CORONARY-HEART-DISEASE; LOW-BIRTH-WEIGHT; CARDIOVASCULAR RISK;
   INSULIN-RESISTANCE; GLUCOCORTICOID-RECEPTOR; ABDOMINAL OBESITY;
   SECRETION; STRESS; PREVALENCE; RESPONSES
AB Objective The metabolic syndrome is more prevalent in South Asians in Britain than in the general population. Furthering our understanding of the underlying mechanisms is important because of the increased risk of cardiovascular disease associated with the metabolic syndrome. As it has been proposed that increased activity of the hypothalamic pituitary adrenal axis might underlie the metabolic syndrome, we hypothesized that plasma cortisol levels would be higher in South Asians and that increased cortisol levels would be associated with cardiovascular risk factors comprising the metabolic syndrome. The aim of the study was to examine ethnic differences in cortisol levels and to compare the relationships between cortisol levels and cardiovascular risk factors in men from different ethnic groups.
   Design Cross-sectional population-based study, Newcastle upon Tyne, UK. (Newcastle Heart project).
   Participants One hundred men, 40-67 years old, of European and South Asian (Indian, Pakistani, Bangladeshi) ancestry, with and without cardiovascular risk factors of the metabolic syndrome.
   Measurements Measurement of plasma cortisol and corticosteroid binding globulin in stored sera.
   Results After adjustment for age and the presence of cardiovascular risk factors, mean cortisol was 27% (95% CI, 10%, 40%) lower in South Asians compared to Europeans. Cortisol levels were higher in all men with cardiovascular risk factors than those without.
   Conclusions Cortisol levels are lower in South Asian than in European men resident in the UK. Despite lower cortisol levels in South Asians, the relations between cortisol and cardiovascular risk factors remain strong.
C1 Univ Edinburgh, Endocrinol Unit, Ctr Cardiovasc Sci, Queens Med Res Inst, Edinburgh EH16 4TJ, Midlothian, Scotland.
   Informat Serv Div, Edinburgh EH12 9EB, Midlothian, Scotland.
   Univ Edinburgh, Div Community Hlth Sci, Publ Hlth Sci Sect, Edinburgh EH8 9AG, Midlothian, Scotland.
   Southampton Univ Hosp Trust, Southampton Gen Hosp, Southampton SO16 6YD, Hants, England.
   Newcastle Univ, Sch Populat & Hlth Sci, Publ Hlth Res Grp, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England.
C3 University of Edinburgh; University of Edinburgh; University of
   Southampton; University Hospital Southampton NHS Foundation Trust;
   Newcastle University - UK
RP Univ Edinburgh, Endocrinol Unit, Ctr Cardiovasc Sci, Queens Med Res Inst, 47 Little France Crescent, Edinburgh EH16 4TJ, Midlothian, Scotland.
EM R.Reynolds@ed.ac.uk
RI White, Martin/G-2410-2010; Reynolds, Rebecca M/C-3044-2008
OI Fischbacher, Colin/0000-0003-3090-1857; Byrne, Christopher
   D/0000-0001-6322-7753; Reynolds, Rebecca M/0000-0001-6226-8270; Unwin,
   Nigel/0000-0002-1368-1648; White, Martin/0000-0002-1861-6757
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NR 31
TC 17
Z9 19
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0300-0664
EI 1365-2265
J9 CLIN ENDOCRINOL
JI Clin. Endocrinol.
PD MAY
PY 2006
VL 64
IS 5
BP 530
EP 534
DI 10.1111/j.1365-2265.2006.02504.x
PG 5
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 034PR
UT WOS:000236943600010
PM 16649972
DA 2025-06-11
ER

PT J
AU McCloughen, A
   Foster, K
   Huws-Thomas, M
   Delgado, C
AF McCloughen, Andrea
   Foster, Kim
   Huws-Thomas, Michelle
   Delgado, Cynthia
TI Physical health and wellbeing of emerging and young adults with mental
   illness: An integrative review of international literature
SO INTERNATIONAL JOURNAL OF MENTAL HEALTH NURSING
LA English
DT Article
DE comorbid; mental illness; physical health; young adults
ID QUALITY-OF-LIFE; BORDERLINE PERSONALITY-DISORDER; MEDICAL COMORBIDITY;
   METABOLIC SYNDROME; ANXIETY DISORDERS; RISK-FACTORS; PREVALENCE; PEOPLE;
   IMPACT; SCHIZOPHRENIA
AB Physical health in people with mental illness is often compromised. Chronic physical conditions and disease risk factors occur at higher rates than in the general population. Although substantial research exists regarding mentalphysical comorbidities in middle to older-aged adults and mental illness consequential to childhood physical illness, research addressing physical health in young people/emerging adults of 1624 years with primary mental illnesses is minimal. Health problems often track from youth to adulthood, indicating a need to better recognize and understand the overall health of young people with mental illness. This paper reports findings from an integrative review of published research investigating physical health of emerging/young adults with mental illness. A total of 18 research papers were systematically analysed. The review found that comorbid mentalphysical illness/conditions were evident across a wide age span. Specific physical health problems, including pain, gastrointestinal, and respiratory disorders, were apparent in those 16 years to those in their midlate 20s, and/or with first episode psychosis. Lifestyle risk factors for cardiometabolic disorders occurred with some frequency and originated prior to adulthood. These findings highlight the need for targeted health screening and illness prevention strategies for emerging/young adults with mental health problems and draws attention to the need for young people to be supported in their health-care behaviours.
C1 [McCloughen, Andrea; Foster, Kim; Delgado, Cynthia] Univ Sydney, Sydney Nursing Sch, Camperdown, NSW 2050, Australia.
   [Huws-Thomas, Michelle] Univ W England, Dept Psychol, Fac Hlth & Life Sci, Bristol BS16 1QY, Avon, England.
C3 University of Sydney; University of West England
RP McCloughen, A (corresponding author), Univ Sydney, Sydney Nursing Sch, Bldg MO2,88 Mallet St, Camperdown, NSW 2050, Australia.
EM andrea.mccloughen@sydney.edu.au
RI McCloughen, Andrea/AFO-0635-2022
OI McCloughen, Andrea/0000-0002-5045-0558; Delgado,
   Cynthia/0000-0002-9976-2181; Foster, Kim/0000-0001-6931-2422
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NR 71
TC 66
Z9 82
U1 3
U2 46
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1445-8330
EI 1447-0349
J9 INT J MENT HEALTH NU
JI Int. J. Ment. Health Nurs.
PD JUN
PY 2012
VL 21
IS 3
SI SI
BP 274
EP 288
DI 10.1111/j.1447-0349.2011.00796.x
PG 15
WC Nursing; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Psychiatry
GA 931RS
UT WOS:000303237600011
PM 22533335
DA 2025-06-11
ER

PT J
AU Klisic, A
   Kocic, G
   Kavaric, N
   Pavlovic, R
   Soldatovic, I
   Ninic, A
AF Klisic, Aleksandra
   Kocic, Gordana
   Kavaric, Nebojsa
   Pavlovic, Radmila
   Soldatovic, Ivan
   Ninic, Ana
TI NITRIC OXIDE PRODUCTS ARE NOT ASSOCIATED WITH METABOLIC SYNDROME
SO JOURNAL OF MEDICAL BIOCHEMISTRY
LA English
DT Article
DE inflammation; metabolic syndrome; obesity; oxidative stress
ID OXIDATIVE STRESS; RISK; CORRELATE; OBESITY; ACID
AB Background: Nitric oxide (NO) is oxidative stress biomarker which is regarded as one of the key determinants of energy metabolism and vascular tone. Considering the controversial reports on the association between nitric oxide products (NOx) and metabolic syndrome (MetS), the aim of the current study was to examine that potential relationship. Additionally, we aimed to evaluate a broad spectrum of other oxidative stress biomarkers [i.e., malondialdehyde (MDA), advanced oxidation protein products (AOPP), xanthine oxidoreductase (XOD), xanthine oxidase (XO) xanthine dehydrogenase (XDH)] in relation with MetS.
   Methods: A total of 109 volunteers (46.8% of them with MetS) were included in this cross-sectional study. Biohemical and anthropometric parameters, as well as blood pressure, were obtained. The MetS was diagnosed according to the International Diabetes Federation criteria.
   Results: Multivariate logistic regression analysis showed that XOD (OR=1.011; 95% CI 1.002-1.019; p=0.016), XO (OR=1.014; 95% CI 1.003-1.026; p=0.016), MDA (OR=1.113; 95% CI 1.038-1.192; p=0.003) and AOPP (OR=1.022; 95% CI 1.005-1.039; p=0.012) were the independent predictors of MetS, whereas no association between NOx and MetS was found. As XOD rose for 1 U/L, XO for 1 U/L, MDA for 1 mu mol/L and AOPP for 1 T/L, probability for MetS rose for 1.1%, 1.4%, 11.3% and 2.2%, respectively. Adjusted R-2 for the Model was 0.531, which means that 53.1% of variation in MetS could be explained with this Model.
   Conclusions: Unlike XOD, MDA and AOPP, NOx is not associated with MetS.
C1 [Klisic, Aleksandra; Kavaric, Nebojsa] Univ Montenegro, Fac Med, Primary Hlth Care Ctr, Podgorica, Montenegro.
   [Kocic, Gordana] Univ Nis, Sch Med, Dept Med Biochem, Nish, Serbia.
   [Pavlovic, Radmila] Univ Milan, Dept Hlth Anim Sci & Food Safety, Milan, Italy.
   [Soldatovic, Ivan] Univ Belgrade, Inst Biostat Med Informat & Res Med, Fac Med, Belgrade, Serbia.
   [Ninic, Ana] Univ Belgrade, Fac Pharm, Dept Med Biochem, Belgrade, Serbia.
C3 University of Montenegro; University of Nis; University of Milan;
   University of Belgrade; University of Belgrade
RP Klisic, A (corresponding author), Primary Hlth Care Ctr, Ctr Lab Diagnost, Nikole Kovacevica Sq 6, Podgorica 81000, Montenegro.
EM aleksandranklisic@gmail.com
RI Ninić, Ana/AAD-6158-2019; Klisic, Aleksandra/ABC-9219-2020
OI Kocic, Gordana/0000-0003-2386-2466; Pavlovic,
   Radmila/0000-0002-2128-4589; Klisic, Aleksandra/0000-0001-7870-0996
FU Ministry of Education, Science and Technological Development, Republic
   of Serbia [175035]
FX Acknowledgement. This work was financially supported in part by a grant
   from the Ministry of Education, Science and Technological Development,
   Republic of Serbia (Project number 175035).
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NR 31
TC 15
Z9 16
U1 0
U2 1
PU SCIENDO
PI WARSAW
PA DE GRUYTER POLAND SP Z O O, BOGUMILA ZUGA 32A STR, 01-811 WARSAW, POLAND
SN 1452-8258
EI 1452-8266
J9 J MED BIOCHEM
JI J. Med. Biochem.
PD JUL
PY 2019
VL 38
IS 3
BP 361
EP 367
DI 10.2478/jomb-2018-0035
PG 7
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA HY8BT
UT WOS:000468363100014
PM 31156347
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Bhaswant, M
   Shafie, SR
   Mathai, ML
   Mouatt, P
   Brown, L
AF Bhaswant, Maharshi
   Shafie, Siti Raihanah
   Mathai, Michael L.
   Mouatt, Peter
   Brown, Lindsay
TI Anthocyanins in chokeberry and purple maize attenuate diet-induced
   metabolic syndrome in rats
SO NUTRITION
LA English
DT Article
DE Anthocyanins; Chokeberry; Aronia melanocarpa; Purple maize; Zea mays;
   Metabolic syndrome
ID ACTIVATED PROTEIN-KINASE; NITRIC-OXIDE SYNTHASE; ARONIA-MELANOCARPA;
   CYANIDIN 3-GLUCOSIDE; INSULIN-RESISTANCE; HIGH-CARBOHYDRATE; OXIDATIVE
   STRESS; WEIGHT-GAIN; BODY-WEIGHT; ZEA-MAYS
AB Objective: Increased consumption of fruits and vegetables as functional foods leads to the reduction of signs of metabolic syndrome. The aim of this study was to measure and compare cardiovascular, liver, and metabolic parameters following chronic administration of the same dose of anthocyanins either from chokeberry (CB) or purple maize (PM) in rats with diet-induced metabolic syndrome.
   Methods: Male Wistar rats were fed a maize starch (C) or high-carbohydrate, high-fat diet (H) and divided into six groups for 16 wk. The rats were fed C, C with CB or PM for the last 8 wk (CCB or CPM), H, H with CB or PM for the last 8 wk (HCB or HPM); CB and PM rats received similar to 8 mg anthocyanins/kg daily. The rats were monitored for changes in blood pressure, cardiovascular and hepatic structure and function, glucose tolerance, and adipose tissue mass.
   Results: HCB and HPM rats showed reduced visceral adiposity index, total body fat mass, and systolic blood pressure; improved glucose tolerance, liver, and cardiovascular structure and function; decreased plasma triacylglycerols and total cholesterol compared with H rats. Inflammatory cell infiltration was reduced in heart and liver.
   Conclusion: CB and PM interventions gave similar responses, suggesting that anthocyanins are the bioactive molecules in the attenuation or reversal of metabolic syndrome by prevention of inflammation-induced damage. (C) 2016 Elsevier Inc. All rights reserved.
C1 [Bhaswant, Maharshi; Mathai, Michael L.] Victoria Univ, Coll Hlth & Biomed, Ctr Chron Dis, Melbourne, Vic, Australia.
   [Bhaswant, Maharshi; Shafie, Siti Raihanah; Brown, Lindsay] Univ Southern Queensland, Sch Hlth & Wellbeing, Toowoomba, Qld, Australia.
   [Mouatt, Peter] Southern Cross Univ, Analyt Res Lab, Southern Cross Plant Sci, E Lismore, Australia.
C3 Victoria University; University of Southern Queensland; Southern Cross
   University
RP Brown, L (corresponding author), Univ Southern Queensland, Sch Hlth & Wellbeing, Toowoomba, Qld, Australia.
EM Lindsay.Brown@usq.edu.au
RI Mouatt, Peter/JRW-8914-2023; Shafie, Siti/AAJ-3033-2020; Bhaswant,
   Maharshi/G-3676-2017; Shafie, Siti/G-1959-2017
OI , Maharshi Bhaswant/0000-0003-4501-5487; Shafie,
   Siti/0000-0003-2983-7536; Mathai, Michael/0000-0001-8783-2122; ,
   Peter/0000-0002-0631-7258
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NR 52
TC 48
Z9 53
U1 1
U2 51
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0899-9007
EI 1873-1244
J9 NUTRITION
JI Nutrition
PD SEP
PY 2017
VL 41
BP 24
EP 31
DI 10.1016/j.nut.2016.12.009
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA FC6ZJ
UT WOS:000406989900005
PM 28760424
DA 2025-06-11
ER

PT J
AU Welles, B
AF Welles, Bernice
TI Glucocorticoids in type 2 diabetes mellitus and the metabolic syndrome
SO DRUG DEVELOPMENT RESEARCH
LA English
DT Article; Proceedings Paper
CT 2nd Annual Metabolic Diseases World Summit on New Drugs for Metabolic
   Syndrome
CY MAY 18-21, 2006
CL Long Beach, CA
DE metabolic syndrome; glucocorticoids; cortisol; 11 beta-hydroxysteroid
   dehydrogenase type 1; 11 beta hydroxylase
AB While glucocorticoids were originally named for their role in glucose metabolism, their role in many aspects of resting and stress-related homeostasis has been elucidated. An accumulation of evidence linking abnormal glucocorticoid metabolism to both type 2 diabetes and metabolic syndrome has led to a search for therapeutic agents that lower levels of cortisol, the principal active glucocorticoid in humans, and/or that block the effects of cortisol excess. Several promising approaches are currently under investigation and some compounds have reached early stage clinical development. A popular approach is the inhibition of the enzyme 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1), which regenerates the active cortisol from cortisone, its inactive form. This approach still awaits clinical proof of concept. Other therapeutic approaches include blockade at the level of the glucocorticoid receptor and inhibition of adrenal cortisol synthesis. Ketoconazole and metyrapone, inhibitors of 110 hydroxylase, the terminal step in adrenal cortisol synthesis, are frequently used to effect pharmacologic adrenalectomy in patients with Cushing's syndrome, a disorder caused by a marked elevation in levels of cortisol. The 2S,4R enantiomer of ketoconazole, which may be safer than racemic ketoconazole, is currently being tested in a phase-2 clinical trial in patients with type 2 diabetes, many of whom have one or more co-morbidities frequently associated with the metabolic syndrome. Given the central role that cortisol appears to play in the development of the metabolic syndrome, it is likely that a single agent may treat multiple components of this syndrome.
C1 DiObex Inc, San Francisco, CA 94103 USA.
RP Welles, B (corresponding author), DiObex Inc, 600 Townsend St Suite,271, San Francisco, CA 94103 USA.
EM bwelles@diobex.com
CR Andrews RC, 2003, J CLIN ENDOCR METAB, V88, P285, DOI 10.1210/jc.2002-021194
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NR 9
TC 8
Z9 9
U1 0
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0272-4391
EI 1098-2299
J9 DRUG DEVELOP RES
JI Drug Dev. Res.
PD JUL
PY 2006
VL 67
IS 7
BP 570
EP 573
DI 10.1002/ddr.20124
PG 4
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Pharmacology & Pharmacy
GA 108XM
UT WOS:000242272500007
DA 2025-06-11
ER

PT J
AU Prajapati, AK
   Prajapati, R
AF Prajapati, Ajay Kumar
   Prajapati, Ruchi
TI Prevalence of metabolic syndrome and its risk factors among the
   government bank's employees of district Bijnor, Uttar Pradesh: A
   cross-sectional study
SO JOURNAL OF FAMILY MEDICINE AND PRIMARY CARE
LA English
DT Article
DE Insulin resistance; metabolic syndrome; MetS; obesity; prevalence;
   screening
ID NCEP ATP III; FAT
AB Background:Metabolic syndrome (MetS) involves having at least 3 out of 5 health conditions that increase the risk of cardiovascular disease, stroke, and type 2 diabetes mellitus. These conditions include increased blood pressure (BP), high blood sugar, excess body fat around the waist, and abnormal cholesterol or triglyceride levels. Each of these conditions is treatable with lifestyle changes and/or medication.Objective:1). To find out the prevalence of MetS and various risk factors associated with it through MetS's screening criteria. 2) To find out the health risk status and stress level among bank's employees in the government sector.Material and Methods:A medical health camp was organised for all bank's employees to rule out the various health-related disorders. Thus, 64 beneficiaries were participated. A detailed history was taken regarding their socio-demographic profile, risk factors affecting the MetS, and stress levels among each individual through the direct personal interview method.Results:As per MetS's screening criteria (NCEP-ATP III), the prevalence of MetS was 7.81% among the bank's employees. The various risk factors affecting the MetS are elevated serum triglyceride level, elevated fasting blood glucose (FBG), raised BP, enlarged WC, etc., The majority of individuals had a high risk of health status 27 (42.1%) and a moderate level of stress, i.e., 38 (59.4%), respectively. Most of the participants were hypertensive 49 (76.6%), diabetic 16 (28.6%), and obese 37 (57.8%).Conclusion:Common concerns of male gender, increasing age and BMI, sedentary lifestyle, stress and positive family history should be considered for early identification and appropriate intervention to fight against the growing MetS epidemic.
C1 [Prajapati, Ajay Kumar] MVASMC, Dept Community Med, Bijnor, Uttar Pradesh, India.
   [Prajapati, Ruchi] Chaudhary Brahm Prakash Ayurved Charak Sansthan, New Delhi, India.
RP Prajapati, AK (corresponding author), Mahatma Vidur Autonomous State Med Coll, Dept Community Med, Bijnor 246701, Uttar Pradesh, India.
EM ajayprajapati112@gmail.com
RI Kumar Prajapati, Ajay/KPA-0976-2024
CR Akshithanand KJ, 2024, INDIAN J PEDIATR, V91, P643, DOI 10.1007/s12098-024-05131-z
   American Heart Association (AHA), 2023, About metabolic Syndrome
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NR 25
TC 0
Z9 0
U1 0
U2 0
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, Maharashtra, INDIA
SN 2249-4863
EI 2278-7135
J9 J FAM MED PRIM CARE
JI J. Fam. Med. Prim. Care
PD DEC
PY 2024
VL 13
IS 12
BP 5825
EP 5832
DI 10.4103/jfmpc.jfmpc_949_24
PG 8
WC Primary Health Care
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA O8R6V
UT WOS:001373737800012
PM 39790761
OA gold
DA 2025-06-11
ER

PT J
AU Spanidis, Y
   Mpesios, A
   Stagos, D
   Goutzourelas, N
   Bar-Or, D
   Karapetsa, M
   Zakynthinos, E
   Spandidos, DA
   Tsatsakis, AM
   Leon, G
   Kouretas, D
AF Spanidis, Ypatios
   Mpesios, Anastasios
   Stagos, Dimitrios
   Goutzourelas, Nikolaos
   Bar-Or, David
   Karapetsa, Maria
   Zakynthinos, Epaminondas
   Spandidos, Demetriosa A.
   Tsatsakis, Aristides M.
   Leon, George
   Kouretas, Demetrios
TI Assessment of the redox status in patients with metabolic syndrome and
   type 2 diabetes reveals great variations
SO EXPERIMENTAL AND THERAPEUTIC MEDICINE
LA English
DT Article
DE type 2 diabetes; metabolic syndrome; oxidative stress; oxidation
   reduction potential
ID OXIDATION PROTEIN PRODUCTS; INSULIN-RESISTANCE; LIPID-PEROXIDATION;
   STRESS MARKERS; SERUM-LEVELS; BIOMARKERS; EXERCISE; MELLITUS;
   GLUTATHIONE; DISEASE
AB The aim of the present study was to examine the effectiveness of a new redox status marker, the static oxidation reduction potential (sORP), for assessing oxidative stress in 75 patients with metabolic syndrome (MetS) and type 2 diabetes (T2D). A total of 35 normal subjects were used as the controls. Moreover, conventional markers of oxidative stress were assessed, such as thiobarbituric acid reactive substances (TBARS), protein carbonyls, the total antioxidant capacity in plasma, glutathione (GSH) levels and catalase (CAT) activity in erythrocytes. The results revealed that sORP was significantly higher (by 13.4%) in the patients with MetS and T2D compared to the controls, indicating an increase in oxidative stress. This finding was also supported by the significantly lower levels (by 27.7%) of GSH and the higher levels (by 23.3%) of CAT activity in the patients with MetS and T2D compared to the controls. Moreover, our results indicated a great variation in oxidative stress markers between the different patients with MetS and T2D, particarly as regards the GSH levels. Thus, the patients with MetS and T2D were divided into 2 subgroups, one with low GSH levels (n=31; GSH <3 mu mol/g Hb) and another with high GSH levels (n=35; GSH >4 mu mol/g Hb). The comparison of the markers between the 2 subgroups indicated that in the low GSH group, the GSH levels were significantly lower (by 51.7 and 52.9%) than those in the high GSH group and the controls, respectively. Furthermore, sORP in the low GSH group was significantly higher (by 8.1%) compared to the high GSH group, suggesting its sensitivity for assessing oxidative stress in patients wtih MetS and T2D. Moreover, this variation in oxidative stress levels between the different patients with T2D suggests that the assessment of the redox status may be important in prediabetic conditions, since there is evidence indicating that differences in the redox status in pre-diabetes may result in different outcomes.
C1 [Spanidis, Ypatios; Mpesios, Anastasios; Stagos, Dimitrios; Goutzourelas, Nikolaos; Kouretas, Demetrios] Univ Thessaly, Dept Biochem & Biotechnol, Ploutonos 26 & Aiolou St, Larisa 41221, Greece.
   [Bar-Or, David] St Anthony Hosp, Dept Trauma Res, Lakewood, CO 80228 USA.
   [Bar-Or, David] Swedish Med Ctr, Dept Trauma Res, Englewood, CO 80113 USA.
   [Bar-Or, David] Med Ctr Plano, Dept Trauma Res, Plano, TX 75075 USA.
   [Bar-Or, David] Luoxis Diagnost Inc, Englewood, CO 80112 USA.
   [Karapetsa, Maria; Zakynthinos, Epaminondas] Univ Hosp Thessaly Biopolis, Dept Intens Care, Larisa 41110, Greece.
   [Spandidos, Demetriosa A.] Univ Crete, Sch Med, Lab Clin Virol, Iraklion 71409, Greece.
   [Tsatsakis, Aristides M.] Univ Crete, Sch Med, Dept Forens Sci & Toxicol, Iraklion 71003, Greece.
   [Leon, George] Stand Ctr Bioassays Hartografoi Hygeias, Athens 15124, Greece.
C3 University of Thessaly; University of Crete; University of Crete
RP Kouretas, D (corresponding author), Univ Thessaly, Dept Biochem & Biotechnol, Ploutonos 26 & Aiolou St, Larisa 41221, Greece.
EM dkouret@uth.gr
RI Bar-Or, David/AAE-9328-2020; Zakynthinos, Epameinondas/N-9024-2019;
   KOURETAS, DEMETRIOS/ABE-8519-2020; TSATSAKIS, ARISTIDIS/H-2890-2013
OI Spandidos, Demetrios/0000-0002-1146-931X; TSATSAKIS,
   ARISTIDIS/0000-0003-3824-2462
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NR 62
TC 35
Z9 36
U1 0
U2 9
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1792-0981
EI 1792-1015
J9 EXP THER MED
JI Exp. Ther. Med.
PD MAR
PY 2016
VL 11
IS 3
BP 895
EP 903
DI 10.3892/etm.2016.2968
PG 9
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA DC9PV
UT WOS:000369554400029
PM 26998009
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Oda, E
   Aizawa, Y
AF Oda, Eiji
   Aizawa, Yoshifusa
TI Total bilirubin is inversely associated with metabolic syndrome but not
   a risk factor for metabolic syndrome in Japanese men and women
SO ACTA DIABETOLOGICA
LA English
DT Article
DE Bilirubin; Metabolic syndrome; Oxidative stress; Risk factor
ID CORONARY-HEART-DISEASE; SERUM TOTAL BILIRUBIN; INSULIN-RESISTANCE;
   OXIDATIVE STRESS; ADIPOSE-TISSUE; ANTIOXIDANT; STATEMENT
AB Serum total bilirubin (TB) is a potent antioxidant and inversely associated with metabolic syndrome (MetS) in Asian populations. However, there has been no study which is aimed to investigate whether TB is a risk factor for MetS or not. We investigated cross-sectional and longitudinal associations between TB and MetS in 2,435 Japanese men and 1,436 Japanese women. The odds ratios [95 % confidence interval (CI)] of coexisting MetS for each 1 SD increase in log TB were 0.850 (0.754-0.958) (p = 0.008) in men and 0.809 (0.656-0.998) (p = 0.047) in women adjusted for sex, age, smoking, and other confounding covariates. Those for the third and fourth quartiles of TB compared with the lowest quartile were 0.720 (0.537-0.965) (p = 0.028) and 0.737 (0.530-1.052) (p = 0.095), respectively, in men and 0.822 (0.473-1.427) (p = 0.486) and 0.704 (0.362-1.369) (p = 0.301), respectively, in women. There was a tendency that TB and MetS changed inversely to each other. The similarly adjusted hazard ratios of developing MetS for each 1 SD increase in log TB and for the higher quartiles of TB compared with the lowest quartile were not significant either in men or in women. TB is inversely associated with MetS but not a risk factor for MetS in Japanese men and women.
C1 [Oda, Eiji] Tachikawa Med Ctr, Med Check Up Ctr, Nagaoka, Niigata 9400053, Japan.
   [Aizawa, Yoshifusa] Tachikawa Med Ctr, Dept Res & Dev, Nagaoka, Niigata 9400053, Japan.
RP Oda, E (corresponding author), Tachikawa Med Ctr, Med Check Up Ctr, Nagachou 2-2-16, Nagaoka, Niigata 9400053, Japan.
EM ijie@venus.sannet.ne.jp
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NR 32
TC 27
Z9 30
U1 0
U2 7
PU SPRINGER-VERLAG ITALIA SRL
PI MILAN
PA VIA DECEMBRIO, 28, MILAN, 20137, ITALY
SN 0940-5429
EI 1432-5233
J9 ACTA DIABETOL
JI Acta Diabetol.
PD JUN
PY 2013
VL 50
IS 3
BP 417
EP 422
DI 10.1007/s00592-012-0447-5
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 159SP
UT WOS:000320066500016
PM 23224110
DA 2025-06-11
ER

PT J
AU Shayea, AMF
   Alshatti, AA
   Alfadhli, DH
   Ibrahim, AF
   Almutairi, MK
   Nadar, MS
AF Shayea, Abdulaziz M. F.
   Alshatti, Amna A.
   Alfadhli, Danah H.
   Ibrahim, Almutairi Fatimah
   Almutairi, Mariam Kh.
   Nadar, Mohammed Sh.
TI Health-related factors and dysregulation of epigenetic related genes in
   metabolic syndrome trigger finger patients and smoker trigger finger
   patients: preliminary analysis of patient-derived sample
SO JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
LA English
DT Article
DE Trigger fingers; Metabolic syndrome; Smoking, inflammation
ID LIFE SATISFACTION; BLOOD-PRESSURE; HYPERTENSION; MANAGEMENT; QUALITY;
   TENDON; HAND
AB Purpose To investigate the health-related factors and analyze the expression of epigenetic related genes and inflammatory genes in metabolic syndrome Trigger Finger (TF) and smoker TF. Methods Samples from patients' fingers with symptomatic TF were collected. There were seven groups: healthy control group, carpal tunnel syndrome (as a control for gene expression analysis), TF, diabetic TF, hypertensive TF, dyslipidemic TF and smoker TF. The expression levels of epigenetic related genes and inflammatory genes in metabolic syndrome TF and smoker TF were evaluated by the reverse transcription-polymerase chain reaction (RT-PCR) technique. The Perceived Stress Scale (PSS), Pittsburgh Sleep Quality Index (PSQI) questionnaires, disability of the arm, shoulder and hand (DASH) and numeric pain rating scale were given to the participants to fill out. Results There was a significant increase in hand dysfunction in the metabolic TF groups and smoker group compared to the TF group (p < 0.0001). The stress levels of the smoker TF group and TF with hypertension group were significantly increased compared with those in the TF group (p < 0.03) and (p < 0.021), respectively. On the other hand, there was a significant increase in the COL-I, COL-II and TNF-alpha gene expression of the metabolic TF groups and smoker group (p < 0.0001). Conclusions Health-related factors in the TF tendons was highly associated with the level of inflammation and genetic alteration in TF metabolic syndromes and smoker TF patients. Therefore, further investigation is required to examine the combination of occupational therapy, gene expression, and health-related factors as a promising method of managing TF.
C1 [Shayea, Abdulaziz M. F.; Alshatti, Amna A.; Alfadhli, Danah H.; Ibrahim, Almutairi Fatimah; Almutairi, Mariam Kh.; Nadar, Mohammed Sh.] Kuwait Univ, Fac Allied Hlth Sci, Occupat Therapy Dept, POB 24923, Safat 13110, Kuwait.
   [Shayea, Abdulaziz M. F.] Kuwait Univ, Fac Med, Dept Anat, Neurosci Felid, POB 24923, Safat 13110, Kuwait.
   [Shayea, Abdulaziz M. F.] Kuwait Univ, Fac Grad Studies, Dept Mol Biol, POB 24923, Safat 13110, Kuwait.
C3 Kuwait University; Kuwait University; Kuwait University
RP Shayea, AMF (corresponding author), Kuwait Univ, Fac Allied Hlth Sci, Occupat Therapy Dept, POB 24923, Safat 13110, Kuwait.; Shayea, AMF (corresponding author), Kuwait Univ, Fac Med, Dept Anat, Neurosci Felid, POB 24923, Safat 13110, Kuwait.; Shayea, AMF (corresponding author), Kuwait Univ, Fac Grad Studies, Dept Mol Biol, POB 24923, Safat 13110, Kuwait.
EM Abdulazez.shayee@ku.edu.kw
RI Shayea, Abdulaziz/IVH-2899-2023; Nadar, Mohammed/HNR-9548-2023
OI Nadar, Mohammed/0000-0003-4281-5630
FU Ministry of Health, Kuwait
FX The authors express their sincere gratitude to Dr. Abdullah Al-Awadhi,
   an orthopedic Surgeon et al.-Razi Orthopedic Hospital, Ministry of
   Health, Kuwait.
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NR 55
TC 0
Z9 0
U1 0
U2 2
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1749-799X
J9 J ORTHOP SURG RES
JI J. Orthop. Surg. Res.
PD OCT 18
PY 2023
VL 18
IS 1
AR 785
DI 10.1186/s13018-023-04271-w
PG 17
WC Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics
GA HB3K6
UT WOS:001156988300002
PM 37853419
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Guillemot-Legris, O
   Muccioli, GG
AF Guillemot-Legris, Owein
   Muccioli, Giulio G.
TI Obesity-Induced Neuroinflammation: Beyond the Hypothalamus
SO TRENDS IN NEUROSCIENCES
LA English
DT Review
ID HIGH-FAT DIET; BLOOD-BRAIN-BARRIER; ENDOPLASMIC-RETICULUM STRESS;
   HIPPOCAMPAL-DEPENDENT MEMORY; CENTRAL-NERVOUS-SYSTEM; ELEVATED
   PLUS-MAZE; GRAY-MATTER VOLUME; C-REACTIVE PROTEIN; HIGH-ENERGY DIET;
   BODY-MASS INDEX
AB Obesity is now a worldwide health issue. Far from being limited to weight gain, obesity is generally associated with low-grade inflammation and with a cluster of disorders collectively known as the 'metabolic syndrome'. When considering obesity and the subsequent neuroinflammation, the focus was long set on the hypothalamus. More recently, obesity-derived neuroinflammation has been shown to affect other brain structures such as the hippocampus, cortex, brainstem, or amygdala. Furthermore, obesity has been associated with increased occurrence of central disorders such as depression and impaired cognitive function. We discuss here the effects and mechanisms of obesity-derived neuroinflammation, with a specific emphasis on extra-hypothalamic structures, as well as the repercussions of neuroinflammation for some cerebral functions.
C1 [Guillemot-Legris, Owein; Muccioli, Giulio G.] Catholic Univ Louvain, LDRI, Bioanal & Pharmacol Bioact Lipids Res Grp BPBL, Ave Mounier 72,B1-72-01, B-1200 Brussels, Belgium.
C3 Universite Catholique Louvain
RP Muccioli, GG (corresponding author), Catholic Univ Louvain, LDRI, Bioanal & Pharmacol Bioact Lipids Res Grp BPBL, Ave Mounier 72,B1-72-01, B-1200 Brussels, Belgium.
EM giulio.muccioli@uclouvain.be
OI Muccioli, Giulio/0000-0002-1600-9259; Guillemot-Legris,
   Owein/0000-0003-3738-3423
FU Fonds Speciaux de Recherches (FSR, Universite Catholique de Louvain);
   Fonds de la Recherche Scientifique (FRS)/Fonds National de la Recherche
   Scientifique (FNRS), Belgium
FX O.G.L. is a research fellow of the Fonds pour la Recherche dans
   l'Industrie et l'Agriculture (FRIA, Belgium) and the recipient of a
   Bourse du Patrimoine from the Universite Catholique de Louvain. G.G.M.
   is the recipient of subsidies from the Fonds Speciaux de Recherches
   (FSR, Universite Catholique de Louvain) and from the Fonds de la
   Recherche Scientifique (FRS)/Fonds National de la Recherche Scientifique
   (FNRS), Belgium.
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NR 111
TC 389
Z9 437
U1 10
U2 125
PU ELSEVIER SCIENCE LONDON
PI LONDON
PA 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND
SN 0166-2236
EI 1878-108X
J9 TRENDS NEUROSCI
JI Trends Neurosci.
PD APR
PY 2017
VL 40
IS 4
BP 237
EP 253
DI 10.1016/j.tins.2017.02.005
PG 17
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology
GA ES3LI
UT WOS:000399430700006
PM 28318543
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Martins, CC
   Bagatini, MD
   Simoes, JLB
   Cardoso, AM
   Baldissarelli, J
   Dalenogare, DP
   dos Santos, DL
   Schetinger, MRC
   Morsch, VM
AF Martins, Caroline Curry
   Bagatini, Margarete Dulce
   Batista Simoes, Julia Leao
   Cardoso, Andreia Machado
   Baldissarelli, Jucimara
   Dalenogare, Diessica Padilha
   dos Santos, Daniela Lopes
   Chitolina Schetinger, Maria Rosa
   Morsch, Vera Maria
TI Increased oxidative stress and inflammatory markers contrasting with the
   activation of the cholinergic anti-inflammatory pathway in patients with
   metabolic syndrome
SO CLINICAL BIOCHEMISTRY
LA English
DT Article
DE Inflammation; Metabolic syndrome; Obesity; Oxidative stress; Cholinergic
   anti-inflammatory pathway
AB Introduction: Metabolic syndrome (MetS) is a disorder that is closely associated with risk factors that increase the chance of atherosclerosis and cardiovascular diseases. We demonstrate the presence of inflammation and oxidative stress in patients with MetS through levels of antioxidants and oxidative and inflammatory markers, in order to determine influential variables in therapy. Methods: In this study, lipid peroxidation, carbonylated protein content and enzymatic and non-enzymatic antioxidants were evaluated in samples obtained from 30 patients with MetS and 30 control patients. In addition, acetylcholinesterase (AChE) activity, C-reactive protein (CRP) and uric acid (UA) levels were determined to investigate the inflammatory process in patients with MetS.
   Results: Our results demonstrated an increase in the levels of oxidative markers, such as substances reactive to thiobarbituric acid (TBARS) and carbonyl protein. In addition, a decrease in the defense of non-enzymatic antioxidants, such as levels of vitamin C and glutathione (GSH) in patients with MetS. As for inflammatory markers, CRP and UA were increased in patients with MetS. Finally, activation of the cholinergic anti-inflammatory pathway was observed due to decreased AchE activity in patients with MetS.
   Conclusion: The analyzes indicated oxidative stress, together with a reduction in the levels of antioxidant enzymes, corroborating the high consumption of these proteins. In addition, inflammation and activation of the cholinergic anti-inflammatory pathway was observed by the AChE analysis. Thus, the activation of this pathway can be studied as a possible route to a potential therapy. In addition, the markers AChE, CRP and UA may be used as a focus for the treatment of MetS.
C1 [Martins, Caroline Curry; Baldissarelli, Jucimara; Dalenogare, Diessica Padilha; Chitolina Schetinger, Maria Rosa; Morsch, Vera Maria] Univ Fed Santa Maria, Postgrad Program Biol Sci Toxicol Biochem, Ctr Nat & Exact Sci, Santa Maria, RS, Brazil.
   [Bagatini, Margarete Dulce; Cardoso, Andreia Machado] Fed Univ Fronteira Sul, Grad Program Biomed Sci, Chapeco, SC, Brazil.
   [Batista Simoes, Julia Leao] Fed Univ Fronteira Sul, Med Sch, Chapeco, SC, Brazil.
   [dos Santos, Daniela Lopes] Univ Fed Santa Maria, Phys Educ Ctr, Phys Act Grp, Santa Maria, RS, Brazil.
C3 Universidade Federal de Santa Maria (UFSM); Universidade Federal da
   Fronteira Sul; Universidade Federal da Fronteira Sul; Universidade
   Federal de Santa Maria (UFSM)
RP Bagatini, MD (corresponding author), Fed Univ Fronteira Sul, Grad Program Biomed Sci, Chapeco, SC, Brazil.
EM margarete.bagatini@uffs.edu.br
RI Cardoso, Andréia/ABH-9732-2020; dos Santos, Daniela/AAU-2310-2021;
   Morsch, Vera/M-6215-2014; Schetinger, Maria/JAC-4640-2023; Padilha
   Dalenogare, Diéssica/IUM-5367-2023; Bagatini, Margarete/K-3756-2016;
   Baldissarelli, Jucimara/U-4563-2017
OI Cardoso, Andreia/0000-0003-4243-8855; Bagatini,
   Margarete/0000-0001-9263-4980; Santos, Daniela/0000-0002-1782-1337;
   Morsch, Vera Maria/0000-0002-5381-4556; Simoes,
   Julia/0000-0002-1652-9692; Baldissarelli, Jucimara/0000-0002-1114-0063
FU Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq);
   Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
FX The authors wish to thank Conselho Nacional de Desenvolvimento
   Cientifico e Tecnologico (CNPq) and Coordenacao de Aperfeicoamento de
   Pessoal de Nivel Superior (CAPES) for financial support.
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NR 52
TC 18
Z9 20
U1 0
U2 6
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0009-9120
EI 1873-2933
J9 CLIN BIOCHEM
JI Clin. Biochem.
PD MAR
PY 2021
VL 89
BP 63
EP 69
DI 10.1016/j.clinbiochem.2020.12.007
EA FEB 2021
PG 7
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA QI6SC
UT WOS:000619106800007
PM 33333061
DA 2025-06-11
ER

PT J
AU Ullah, R
   Khan, M
   Shah, SA
   Saeed, K
   Kim, MO
AF Ullah, Rahat
   Khan, Mehtab
   Shah, Shahid Ali
   Saeed, Kamran
   Kim, Myeong Ok
TI Natural Antioxidant Anthocyanins-A Hidden Therapeutic Candidate in
   Metabolic Disorders with Major Focus in Neurodegeneration
SO NUTRIENTS
LA English
DT Review
DE oxidative stress; metabolic syndrome; Alzheimer's disease; Parkinson's
   disease; anthocyanins; neuroprotection
ID AMYLOID-BETA-PEPTIDE; INDUCED OXIDATIVE STRESS; MONOAMINE-OXIDASE
   INHIBITORS; ACTIVATED PROTEIN-KINASE; ALZHEIMERS-DISEASE; REACTIVE
   OXYGEN; PARKINSONS-DISEASE; MITOCHONDRIAL DYSFUNCTION; FREE-RADICALS;
   NEURONAL APOPTOSIS
AB All over the world, metabolic syndrome constitutes severe health problems. Multiple factors have been reported in the pathogenesis of metabolic syndrome. Metabolic disorders result in reactive oxygen species (ROS) induced oxidative stress, playing a vital role in the development and pathogenesis of major health issues, including neurological disorders Alzheimer's disease (AD) Parkinson's disease (PD). Considerable increasing evidence indicates the substantial contribution of ROS-induced oxidative stress in neurodegenerative diseases. An imbalanced metabolism results in a defective antioxidant defense system, free radicals causing inflammation, cellular apoptosis, and tissue damage. Due to the annual increase in financial and social burdens, in addition to the adverse effects associated with available synthetic agents, treatment diversion from synthetic to natural approaches has occurred. Antioxidants are now being considered as convincing therapeutic agents against various neurodegenerative disorders. Therefore, medicinal herbs and fruits currently receive substantially more attention as commercial sources of antioxidants. In this review, we argue that ROS-targeted therapeutic interventions with naturally occurring antioxidant flavonoid, anthocyanin, and anthocyanin-loaded nanoparticles might be the ultimate treatment against devastating illnesses. Furthermore, we elucidate the hidden potential of the neuroprotective role of anthocyanins and anthocyanin-loaded nanoparticles in AD and PD neuropathies, which lack sufficient attention compared with other polyphenols, despite their strong antioxidant potential. Moreover, we address the need for future research studies of native anthocyanins and nano-based-anthocyanins, which will be helpful in developing anthocyanin treatments as therapeutic mitochondrial antioxidant drug-like regimens to delay or prevent the progression of neurodegenerative diseases, such as AD and PD.
C1 [Ullah, Rahat; Khan, Mehtab; Shah, Shahid Ali; Saeed, Kamran; Kim, Myeong Ok] Gyeongsang Natl Univ, Coll Nat Sci, Div Appl Life Sci BK 21, Jinju 52828, South Korea.
   [Shah, Shahid Ali] Sarhad Univ Sci Informat Technol SUIT, Dept Chem, Peshawar 25000, Khyber Pakhtunk, Pakistan.
C3 Gyeongsang National University
RP Kim, MO (corresponding author), Gyeongsang Natl Univ, Coll Nat Sci, Div Appl Life Sci BK 21, Jinju 52828, South Korea.
EM rahatullah1414@gnu.ac.kr; mehtabneuro@gnu.ac.kr;
   alishahshahid@yahoo.com; kamran.biochem@gnu.ac.kr; mokim@gnu.ac.kr
RI Ullah, Rahat/HNB-6106-2023; Kim, Myeong/AAS-1488-2021; Khan,
   Mehtab/HHN-0572-2022
FU National Research Foundation of Korea (NRF) - Ministry of Science, ICT
   [2016M3C7A1904391]
FX This review was supported by the Brain Research Program through the
   National Research Foundation of Korea (NRF) funded by the Ministry of
   Science, ICT (2016M3C7A1904391).
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NR 216
TC 110
Z9 113
U1 4
U2 55
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JUN
PY 2019
VL 11
IS 6
AR 1195
DI 10.3390/nu11061195
PG 32
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA II1AJ
UT WOS:000474936700001
PM 31141884
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Balderas-Villalobos, J
   Molina-Muñoz, T
   Mailloux-Salinas, P
   Bravo, G
   Carvajal, K
   Gómez-Viquez, NL
AF Balderas-Villalobos, Jaime
   Molina-Munoz, Tzindilu
   Mailloux-Salinas, Patrick
   Bravo, Guadalupe
   Carvajal, Karla
   Gomez-Viquez, Norma L.
TI Oxidative stress in cardiomyocytes contributes to decreased SERCA2a
   activity in rats with metabolic syndrome
SO AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
LA English
DT Article
DE metabolic syndrome; heart; sarco(endo) plasmic reticulum Ca2+ ATPase 2a;
   calcium; oxidative stress
ID CARDIAC CONTRACTILE DYSFUNCTION; SARCOPLASMIC-RETICULUM CA2+;
   VENTRICULAR DIASTOLIC DYSFUNCTION; RYANODINE RECEPTORS; ANTIOXIDANT
   ENZYMES; INSULIN-RESISTANCE; HEART-FAILURE; CA2+-ATPASE; CARDIOMYOPATHY;
   SUPEROXIDE
AB Ca+ mishandling due to impaired activity of cardiac sarco(endo) plasmic reticulum Ca2+ ATPase (SERCA2a) has been associated with the development of left ventricular diastolic dysfunction in insulin-resistant cardiomyopathy. However, the molecular causes underlying SERCA2a alterations induced by insulin resistance and related metabolic disorders, such as metabolic syndrome (MetS), are not completely understood. In this study, we used a sucrose-fed rat model of MetS to test the hypothesis that decreased SERCA2a activity is mediated by elevated oxidative stress produced in the MetS heart. Production of ROS and cytosolic Ca2+ concentration were recorded in left ventricular myocytes using confocal imaging. The level of SERCA2a oxidation was determined in left ventricular homogenates by biotinylated iodoacetamide labeling. Compared with control rats, sucrose-fed rats exhibited several characteristics of MetS, including central obesity, insulin resistance, hyperinsulinemia, and hypertriglyceridemia. Moreover, relative to myocytes from control rats, myocytes from MetS rats exhibited elevated basal production of ROS accompanied by slowed cytosolic Ca2+ removal, reflected by prolonged Ca2+ transients. The slowed cytosolic Ca2+ removal was associated with a significant decrease in SERCA2a-mediated Ca2+ reuptake and increased SERCA2a oxidation. Importantly, myocytes from MetS rats treated with the antioxidant N-acetylcysteine showed normal ROS levels and SERCA2a-mediated Ca2+ reuptake as well as accelerated cytosolic Ca2+ removal. These data suggest that elevated oxidative stress may induce oxidative modifications on SERCA2a leading to abnormal function of this protein in the MetS heart.
C1 [Balderas-Villalobos, Jaime; Molina-Munoz, Tzindilu; Mailloux-Salinas, Patrick; Bravo, Guadalupe; Gomez-Viquez, Norma L.] Inst Politecn Nacl, Ctr Invest & Estudios Avanzados, Dept Farmacobiol, Mexico City 14000, DF, Mexico.
   [Balderas-Villalobos, Jaime; Carvajal, Karla] Inst Nacl Pediat, Lab Nutr Expt, Mexico City, DF, Mexico.
C3 CINVESTAV - Centro de Investigacion y de Estudios Avanzados del
   Instituto Politecnico Nacional; Instituto Politecnico Nacional - Mexico
RP Gómez-Viquez, NL (corresponding author), Inst Politecn Nacl, Ctr Invest & Estudios Avanzados, Dept Farmacobiol, Apdo Postal 22026, Mexico City 14000, DF, Mexico.
EM letyviquez@hotmail.com
OI Bravo, Guadalupe/0000-0002-2730-7761; CARVAJAL,
   KARLA/0000-0002-5522-3266; Balderas Villalobos,
   Jaime/0000-0002-4997-2703; MOLINA, TZINDILU/0009-0000-7751-3275;
   Mailloux Salinas, Patrick/0000-0003-4281-8479
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NR 53
TC 71
Z9 75
U1 0
U2 11
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0363-6135
EI 1522-1539
J9 AM J PHYSIOL-HEART C
JI Am. J. Physiol.-Heart Circul. Physiol.
PD NOV
PY 2013
VL 305
IS 9
BP H1344
EP H1353
DI 10.1152/ajpheart.00211.2013
PG 10
WC Cardiac & Cardiovascular Systems; Physiology; Peripheral Vascular
   Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Physiology
GA 246XG
UT WOS:000326574100008
PM 23997093
DA 2025-06-11
ER

PT J
AU Tobore, TO
AF Tobore, Tobore Onojighofia
TI Towards a comprehensive theory of obesity and a healthy diet: The causal
   role of oxidative stress in food addiction and obesity
SO BEHAVIOURAL BRAIN RESEARCH
LA English
DT Review
DE Obesity; Redox status; Prader Willis; Hypothalamus; Leptin resistance;
   Hyperinsulinemia; Insulin resistance; Gilbert disease; Food addiction;
   Reward pathway; Ghrelin; Reductive stress; Oxidative stress;
   Antioxidants; Chronic inflammation; Vegetarian diet; Ketogenic diet;
   Vegan diet; Mediterranean diet; Plant-based diet; Carnivore or
   animal-based diet; Overweight; Cholecystokinin; Adipokinin;
   Adipocytokines; Adiponectin; Reward pathway; Sleep; Genes; Metabolic
   syndrome; Yoga; Meditation
ID HIGH-FAT DIET; ALPHA-LIPOIC ACID; GLUCAGON-LIKE PEPTIDE-1; PLASMA
   GHRELIN LEVELS; SHORT-SLEEP DURATION; STIMULATES CHOLECYSTOKININ
   SECRETION; DECREASED CIRCULATING LEVELS; POTENTIAL TREATMENT TARGET;
   GERMINATED BROWN RICE; BREAST-MILK PROVIDES
AB Background: Obesity is a major public health problem whose prevalence has been rapidly increasing in the United States (U.S), and globally. It is one of the leading causes of preventable deaths globally and contributes to the development of many diseases.
   Methods: The search was limited to studies published in English and other languages involving both animal and human subjects. Articles selected included preclinical studies, randomized clinical trials RCTs, observational studies, meta-analyses, narrative and systemic reviews providing primary quantitative data with a measure of obesity or food addiction as an outcome. Over 5000 articles were found in the first round of search which was filtered to 506 articles.
   Results: Oxidative stress plays a critical role in food addiction and is both a cause and mediator of obesity. Reactive oxygen species play a direct role in adipogenesis and oxidative stress modulates all factors involved in obesity including genetics, sleep, gut microbiome, insulin, ghrelin, inflammation, adipokines, leptin, stress, HPA axis, and the hypothalamus.
   Conclusions: The idea of thinking of combating obesity from the lens of calorie count, low carbohydrate, high or low-fat, vegetarian, vegan, plant-based, or animal-based diet is fundamentally wrong. The best way to look at obesity is through the framework of systemic redox homeostasis. Since redox homeostasis is tilted towards increased reactive oxygen species production, and excessive antioxidant intake can result in oxidative stress, an antioxidant and prooxidant food ratio of 2:3 per meal is the ideal nutritional ratio for good health and ideal weight. A ratio of 3:4 is ideal for obese individuals because of their state of chronic oxidative stress and inflammation. Physical activity, sleep quality, psychological stress, maternal prenatal diet and oxidative stress promoting disease conditions are important modulators of oxidative stress and obesity.
EM tonojig1@jhu.edu
OI Tobore, Tobore/0000-0001-7334-2915
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NR 501
TC 44
Z9 48
U1 1
U2 64
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0166-4328
EI 1872-7549
J9 BEHAV BRAIN RES
JI Behav. Brain Res.
PD APR 20
PY 2020
VL 384
AR 112560
DI 10.1016/j.bbr.2020.112560
PG 21
WC Behavioral Sciences; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Behavioral Sciences; Neurosciences & Neurology
GA LD5JZ
UT WOS:000526067300010
PM 32081711
DA 2025-06-11
ER

PT J
AU Cini, KI
   Dumuid, D
   Francis, KL
   Wulan, NR
   Sawyer, SM
   Agung, FH
   Pham, MD
   Kennedy, EC
   Fisher, J
   Tran, T
   Medise, BE
   Devaera, Y
   Riyanti, A
   Wiweko, B
   Kaligis, F
   Wiguna, T
   Ansariadi, A
   Azzopardi, PS
AF Cini, Karly I.
   Dumuid, Dorothea
   Francis, Kate L.
   Wulan, Nisaa R.
   Sawyer, Susan M.
   Agung, Fransisca Handy
   Pham, Minh D.
   Kennedy, Elissa C.
   Fisher, Jane
   Tran, Thach
   Medise, Bernie E.
   Devaera, Yoga
   Riyanti, Aida
   Wiweko, Budi
   Kaligis, Fransiska
   Wiguna, Tjhin
   Ansariadi, Ansariadi
   Azzopardi, Peter S.
TI The relationship between non-communicable disease risk and mental
   wellbeing in adolescence: a cross-sectional study utilising objective
   measures in Indonesia
SO BMC PUBLIC HEALTH
LA English
DT Article
DE Adolescent; Mental health; Non-communicable diseases; Risk factors;
   Indonesia; Wellbeing; Quality of life
ID QUALITY-OF-LIFE; METABOLIC SYNDROME; OBESOGENIC RISK; DEPRESSION;
   ASSOCIATIONS; VALIDATION; CHILDREN; ANXIETY; HEALTH
AB BackgroundRisk factors for non-communicable diseases (NCDs, cardiovascular diseases, cancers, chronic respiratory diseases, diabetes, and mental disorders) arise in adolescence but are mostly framed as relevant to health in adulthood; little is known about the relationship between co-occurring NCD risks and mental wellbeing in young people. This study aims to describe the prevalence and co-occurrence of distinct NCD risk factors, and how they relate to current mental wellbeing amongst adolescents in Indonesia, a young and populous country where NCD burden is increasing rapidly.MethodsWe assessed NCD risk and mental wellbeing amongst 1,331 school-based 16-18-year-olds in Jakarta (N = 609) and South Sulawesi (N = 722). Five domains of NCD risk (adiposity, substance use, physical inactivity, excess sedentary time, and diet) were either measured or self-reported. In Jakarta, we also measured blood glucose, triglycerides, cholesterol, and blood pressure. Wellbeing was assessed using three indicators: general quality of life (QoL), physical function QoL, and psychological distress. We used linear regression to estimate the associations between co-occurring risks and wellbeing, adjusted for covariates of wellbeing: province, sex, socioeconomic status, and religion.ResultsNCD risk clustering was common, and more than half of adolescents had co-occurring risks in 3 or more of the 5 domains (58.9% (95%CI 53.7-63.9)). Adolescents with any NCD risk were more likely to report psychological distress, with this relationship most pronounced in those with excess sedentary time spent on video gaming and computer use. A higher number of NCD risk factors was associated with poorer psychological wellbeing and decreased general and physical function QoL. In the Jakarta subsample, reduced HDL and raised blood glucose was associated with psychological distress; and a higher number of risk biomarkers was associated with lower physical function QoL.ConclusionsOur analysis also shows that these NCD risks (both individual risks and co-occurring risk count) are related to poorer profiles of mental wellbeing in adolescents, after adjusting for likely confounders.
C1 [Cini, Karly I.; Dumuid, Dorothea; Francis, Kate L.; Sawyer, Susan M.; Kennedy, Elissa C.; Azzopardi, Peter S.] Murdoch Childrens Res Inst, Ctr Adolescent Hlth, Melbourne, Australia.
   [Cini, Karly I.; Francis, Kate L.; Sawyer, Susan M.; Azzopardi, Peter S.] Univ Melbourne, Sch Med Dent & Hlth Sci, Dept Paediat, Melbourne, Australia.
   [Cini, Karly I.; Wulan, Nisaa R.; Pham, Minh D.; Kennedy, Elissa C.; Azzopardi, Peter S.] Burnet Inst, Melbourne, Australia.
   [Dumuid, Dorothea] Univ South Australia, Alliance Res Exercise Nutr & Act ARENA, Allied Hlth & Human Performance, Adelaide, Australia.
   [Agung, Fransisca Handy] Univ Pelita Harapan, Fac Med, Tangerang, Indonesia.
   [Pham, Minh D.; Kennedy, Elissa C.; Fisher, Jane; Tran, Thach] Monash Univ, Sch Publ Hlth & Prevent Med, Melbourne, Australia.
   [Medise, Bernie E.; Devaera, Yoga; Wiweko, Budi; Kaligis, Fransiska; Wiguna, Tjhin] Cipto Mangunkusumo Hosp, Jakarta, Indonesia.
   [Medise, Bernie E.; Devaera, Yoga] Univ Indonesia, Fac Med, Dept Child Hlth, Jakarta, Indonesia.
   [Devaera, Yoga] Univ Indonesia Hosp, Depok, Indonesia.
   [Riyanti, Aida; Wiweko, Budi] Univ Indonesia, Fac Med, Dept Obstet & Gynaecol, Jakarta, Indonesia.
   [Wiweko, Budi] Univ Indonesia, Fac Med, Indonesia Med Educ Res Inst IMERI, Jakarta, Indonesia.
   [Kaligis, Fransiska; Wiguna, Tjhin] Univ Indonesia, Fac Med, Dept Psychiat, Jakarta, Indonesia.
   [Ansariadi, Ansariadi] Hasanuddin Univ, Fac Publ Hlth, Ctr Epidemiol & Populat Hlth Studies, Makassar, Indonesia.
   [Azzopardi, Peter S.] Kids Res Inst, Adolescent Hlth & Wellbeing Program, Adelaide, Australia.
C3 Murdoch Children's Research Institute; University of Melbourne; Burnet
   Institute; University of South Australia; Universitas Pelita Harapan;
   Monash University; University of Indonesia; Dr. Cipto Mangunkusumo
   National Public Hospital; University of Indonesia; University of
   Indonesia; University of Indonesia; University of Indonesia; Universitas
   Hasanuddin
RP Cini, KI (corresponding author), Murdoch Childrens Res Inst, Ctr Adolescent Hlth, Melbourne, Australia.; Cini, KI (corresponding author), Univ Melbourne, Sch Med Dent & Hlth Sci, Dept Paediat, Melbourne, Australia.; Cini, KI (corresponding author), Burnet Inst, Melbourne, Australia.
EM Karly.cini@mcri.edu.au
RI Pham, Minh/H-9632-2012; Tran, Thach/H-7734-2014; Cini,
   Karly/KMA-1173-2024; Dumuid, Dorothea/AAC-7383-2019; azzopardi,
   peter/J-7355-2012; Fisher, Jane/I-1569-2014; Hussain,
   Salman/AAN-9202-2021; Kaligis, Fransiska/MGU-4109-2025
OI Dumuid, Dorothea/0000-0003-3057-0963; Sawyer, Susan/0000-0002-9095-358X
FU National Health and Medical Research Council
FX We wish to acknowledge the contributions of all young people who
   participated in this research, thank you for sharing your time with us
   so generously, and acknowledge the partnership and support from school
   and community partners. Many thanks to the data collection teams in
   Jakarta and Makassar.
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NR 50
TC 1
Z9 1
U1 1
U2 1
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2458
J9 BMC PUBLIC HEALTH
JI BMC Public Health
PD DEC 18
PY 2024
VL 24
IS 1
AR 3416
DI 10.1186/s12889-024-20902-1
PG 15
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA P9K8F
UT WOS:001381014300004
PM 39695503
OA gold
DA 2025-06-11
ER

PT J
AU Beltowski, J
AF Beltowski, Jerzy
TI Leptin and the regulation of endothelial function in physiological and
   pathological conditions
SO CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
LA English
DT Article
DE arterial hypertension; atherosclerosis; endothelial dysfunction;
   endothelium-derived hyperpolarizing factor; leptin; leptin resistance;
   metabolic syndrome; nitric oxide; obesity
ID NITRIC-OXIDE PRODUCTION; C-REACTIVE PROTEIN; II-INDUCED
   VASOCONSTRICTION; DIET-INDUCED OBESITY; SMOOTH-MUSCLE-CELLS;
   BLOOD-PRESSURE; HYPERPOLARIZING FACTOR; INDUCED HYPERTENSION; MEDIATED
   RELAXATION; METABOLIC SYNDROME
AB 1. Obesity and the accompanying metabolic syndrome are among the most important causes of cardiovascular pathologies associated with endothelial dysfunction, such as arterial hypertension and atherosclerosis. This detrimental effect of obesity is mediated, in part, by excessive production of the adipose tissue hormone leptin.
   2. Under physiological conditions leptin induces endothelium-dependent vasorelaxation by stimulating nitric oxide (NO) and endothelium-derived hyperpolarizing factor (EDHF). Leptin activates endothelial NO synthase (eNOS) through a mechanism involving AMP-activated protein kinase (AMPK) and protein kinase B/Akt, which phosphorylates eNOS at Ser(1177), increasing its activity.
   3. Under pathological conditions, such as obesity and metabolic syndrome, the NO-mediated vasodilatory effect of leptin is impaired. Resistance to the acute NO-mimetic effect of leptin is accounted for by chronic hyperleptinaemia and may result from different mechanisms, such as downregulation of leptin receptors, increased levels of circulating C-reactive protein, oxidative stress and overexpression of suppressor of cytokine signalling-3.
   4. In short-lasting obesity, impaired leptin-induced NO production is compensated by EDHF; however, in advanced metabolic syndrome, the contribution of EDHF to the haemodynamic effect of leptin becomes inefficient. Resistance to the vasodilatory effects of leptin may contribute to the development of arterial hypertension owing to unopposed stimulation of the sympathetic nervous system by this hormone.
C1 Med Univ, Dept Pathophysiol, PL-20090 Lublin, Poland.
C3 Medical University of Lublin
RP Beltowski, J (corresponding author), Med Univ, Dept Pathophysiol, Ul Jaczewskiego 8, PL-20090 Lublin, Poland.
EM jerzy.beltowski@umlub.pl
RI Beltowski, Jerzy/AAH-4692-2020
OI Beltowski, Jerzy/0000-0001-7903-8121
FU Medical University, Lublin, Poland [DS 476]; EU [2007-13]
FX The author's original studies concerning the vascular effects of leptin
   cited in this paper were supported by grant DS 476 from Medical
   University, Lublin, Poland, as well as by EU Project 'The equipment of
   innovative laboratories doing research on new medicines used in the
   therapy of civilization and neoplastic diseases' within the Operational
   Program Development of Eastern Poland 2007-13, Priority Axis I Modern
   Economy, Operations I.3 Innovation Promotion.
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NR 77
TC 80
Z9 91
U1 0
U2 11
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1440-1681
J9 CLIN EXP PHARMACOL P
JI Clin. Exp. Pharmacol. Physiol.
PD FEB
PY 2012
VL 39
IS 2
BP 168
EP 178
DI 10.1111/j.1440-1681.2011.05623.x
PG 11
WC Pharmacology & Pharmacy; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Physiology
GA 883FC
UT WOS:000299618600009
PM 21973116
DA 2025-06-11
ER

PT J
AU Mannan, A
   Akter, KM
   Akter, F
   Chy, NUHA
   Alam, N
   Pinky, SD
   Chowdhury, AMN
   Biswas, P
   Chowdhury, AS
   Hossain, MA
   Rana, MM
AF Mannan, Adnan
   Akter, Kazi Mahmuda
   Akter, Farhana
   Chy, Naim Uddin Hasan A.
   Alam, Nazmul
   Pinky, Susmita Dey
   Chowdhury, Abul Faisal Md Nuruddin
   Biswas, Parijat
   Chowdhury, Afrin Sultana
   Hossain, Mohammed Akram
   Rana, Md Mashud
TI Association between comorbidity and health-related quality of life in a
   hypertensive population: a hospital-based study in Bangladesh
SO BMC PUBLIC HEALTH
LA English
DT Article
DE Bangladesh; Hypertension (HTN); Health-Related Quality of Life (HRQoL);
   EQ-5D-3L; Comorbidity
ID METABOLIC SYNDROME; BLOOD-PRESSURE; SF-36
AB Background Hypertension is a known risk factor for several chronic conditions including diabetes and cardiovascular diseases. However, little is known about its impact on Health-related quality of life (HRQoL) in the context of Bangladesh. This study aimed to evaluate the association of hypertension on HRQoL among Bangladeshi patients corresponding to the socio-demographic condition, comorbid conditions, treatment, and health outcomes. Methods A hospital based cross-sectional study was conducted using a pre-tested structured questionnaire among patients with hypertension in 22 tertiary medical college hospitals in Bangladesh. The study recruited male and female hypertensive patients of age >= 18 years between July 2020 to February 2021 using consecutive sampling methods. Health related quality of life was measured using the widely-used index of EQ-5D that considers 243 different health-related attributes and uses a scale in which 0 indicates a health state equivalent to death and 1 indicates perfect health status. The five dimensions of the quality index included mobility, self-care, usual activities, pain or discomfort, and anxiety or depression. Ordered logit regression and linear regression models were used to estimate the predictors of comorbidity and HRQoL. Results Of the 1,912 hypertensive patients, 56.2% were female, 86.5% were married, 70.7% were either overweight or obese, 67.6% had a family history of hypertension, and 85.5% were on anti-hypertensive medication. Among the individuals with comorbidities, 47.6% had diabetes, 32.3% were obese, 16.2% had heart disease, 15% were visually impaired, and 13.8% were suffering from psychological diseases. HRQoL was found to be inversely proportional to the number of comorbidities. The most frequent comorbidities of diabetes and obesity showed the highest EQ- 5D mean utilities of 0.59 and 0.64, respectively. Conclusions Prevalent comorbidities, diabetes and obesity were found to be the significant underlying causes of declining HRQoL. It is recommended that the comorbidities should be adequately addressed for better HRQoL. Special attention should be given to address mental health issues of patients with hypertension.
C1 [Mannan, Adnan] Univ Chittagong, Fac Biol Sci, Dept Genet Engn & Biotechnol, Chattogram 4331, Bangladesh.
   [Akter, Kazi Mahmuda] Sir Salimullah Med Coll, Mitford Hosp, Dept Obstet & Gynaecol, Dhaka 1206, Bangladesh.
   [Akter, Farhana] Chittagong Med Coll, Dept Endocrinol, Chattogram 4203, Bangladesh.
   [Chy, Naim Uddin Hasan A.] Univ Chittagong, Dept Econ, Hlth Econ Res Grp, Chattogram 4331, Bangladesh.
   [Alam, Nazmul] Asian Univ Women, Dept Publ Hlth, Chattogram 4000, Bangladesh.
   [Pinky, Susmita Dey; Chowdhury, Abul Faisal Md Nuruddin; Biswas, Parijat] Chittagong Med Coll, Dept Med, Chattogram 4203, Bangladesh.
   [Chowdhury, Afrin Sultana] Noakhali Sci & Technol Univ, Dept Biotechnol & Genet Engn, Noakhali 3814, Bangladesh.
   [Hossain, Mohammed Akram] 250 Bedded Gen Hosp, Dept Cardiol, Chattogram 4000, Bangladesh.
   [Rana, Md Mashud] Chittagong Med Coll, Dept Pharmacol & Therapeut, Chattogram 4203, Bangladesh.
C3 University of Chittagong; Sir Salimullah Medical College; Chittagong
   Medical College; University of Chittagong; Asian University for Women;
   Chittagong Medical College; Noakhali Science & Technology University
   (NSTU); Chittagong Medical College
RP Mannan, A (corresponding author), Univ Chittagong, Fac Biol Sci, Dept Genet Engn & Biotechnol, Chattogram 4331, Bangladesh.
EM adnan.mannan@cu.ac.bd
OI Alam, Nazmul/0000-0001-6119-8178; Mannan, Adnan/0000-0003-4070-9586;
   Akter, Dr. Kazi Mahmuda/0000-0002-1016-8304
CR Alefishat E, 2020, INT J CLIN PRACT, V74, DOI 10.1111/ijcp.13532
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NR 40
TC 15
Z9 18
U1 0
U2 9
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2458
J9 BMC PUBLIC HEALTH
JI BMC Public Health
PD JAN 26
PY 2022
VL 22
IS 1
AR 181
DI 10.1186/s12889-022-12562-w
PG 12
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA YN3FA
UT WOS:000747145800001
PM 35081905
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Kim, M
   Kim, Y
AF Kim, Minji
   Kim, Yangha
TI Psychosocial stress accompanied by an unhealthy eating behavior is
   associated with abdominal obesity in Korean adults: A community-based
   prospective cohort study
SO FRONTIERS IN NUTRITION
LA English
DT Article
DE psychological stress; obesity; non-communicable disease; dietary
   quality; dietary variety score; longitudinal study; gender
   stratification
ID REFINED-GRAIN CONSUMPTION; TYPE-2 DIABETES-MELLITUS; DIETARY DIVERSITY
   SCORE; METABOLIC SYNDROME; GENDER-DIFFERENCES; SOCIOECONOMIC-STATUS;
   ALCOHOL-CONSUMPTION; GLYCEMIC INDEX; COMFORT FOOD; RISK-FACTORS
AB Psychosocial stress is recognized as a potential modulator of eating behavior. Psychosocial stress also constitutes an independent risk factor for the development of non-communicable diseases. This study examined the gender-stratified associations between perceived stress, eating behavior, and abdominal obesity in 4,411 adults aged 40-69 years during a 10-year follow-up of the Korean Genome and Epidemiology Study (KoGES). Psychosocial stress was evaluated using the Psychosocial Wellbeing Index Short Form (PWI-SF), and eating behavior was analyzed with a focus on the dietary variety score (DVS). The Cox's proportional hazard model was used to examine the risk of abdominal obesity according to stress levels. Higher stress levels were associated with lower DVS in women. Lower DVS scores were positively associated with the consumption of grains and refined grains but was negatively associated with the consumption of fruits. The DVS was not significantly associated with stress levels among men. Prospectively, the highest tertile of grains and refined grains consumption showed an increased risk of abdominal obesity compared to the lowest tertile in women (HR: 1.36, 95% CI: 1.04-1.78, p < 0.05; HR: 1.28, 95% CI: 1.03-1.59, p < 0.05, respectively). By contrast, in all participants, the highest tertile of fruits consumption decreased the risk of abdominal obesity compared to the lowest tertile (men, HR: 0.56, 95% CI: 0.45-0.70, p < 0.01; women, HR: 0.51, 95% CI: 0.40-0.65, p < 0.01). Furthermore, high stress levels showed a borderline significant association with the risk of abdominal obesity only in women (HR: 1.27, 95% CI: 1.00-1.59, p < 0.05). These findings suggested that psychosocial stress might contribute to abdominal obesity by interacting with eating behavior represented by a low DVS. The approach to consume a diet with a high DVS might help decrease the risk of abdominal obesity among people in stressful environments.
C1 [Kim, Minji; Kim, Yangha] Ewha Womans Univ, Dept Nutr Sci & Food Management, Seoul, South Korea.
   [Kim, Minji; Kim, Yangha] Ewha Womans Univ, Grad Program Syst Hlth Sci & Engn, Seoul, South Korea.
C3 Ewha Womans University; Ewha Womans University
RP Kim, Y (corresponding author), Ewha Womans Univ, Dept Nutr Sci & Food Management, Seoul, South Korea.; Kim, Y (corresponding author), Ewha Womans Univ, Grad Program Syst Hlth Sci & Engn, Seoul, South Korea.
EM yhmoon@ewha.ac.kr
FU BK21 FOUR (Fostering Outstanding Universities for Research) - Ministry
   of Education (MOE, Korea); National Research Foundation of Korea
   [NRF-5199990614253]
FX This research was supported by the BK21 FOUR (Fostering Outstanding
   Universities for Research) funded by the Ministry of Education (MOE,
   Korea) and National Research Foundation of Korea (NRF-5199990614253).
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NR 73
TC 4
Z9 4
U1 0
U2 7
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD SEP 30
PY 2022
VL 9
AR 949012
DI 10.3389/fnut.2022.949012
PG 13
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 5K9KJ
UT WOS:000870036800001
PM 36245532
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Wells, GD
   Noseworthy, MD
   Hamilton, J
   Tarnopolski, M
   Tein, I
AF Wells, Greg D.
   Noseworthy, Michael D.
   Hamilton, Jill
   Tarnopolski, Mark
   Tein, Ingrid
TI Skeletal muscle metabolic dysfunction in obesity and metabolic syndrome
SO CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES
LA English
DT Review
ID ACTIVATED PROTEIN-KINASE; ADENINE-NUCLEOTIDE TRANSLOCATOR;
   INTRAMYOCELLULAR LIPID-CONTENT; IMPAIRED GLUCOSE-TOLERANCE; INDUCED
   INSULIN-RESISTANCE; ACETYL-COA CARBOXYLASE; FATTY-ACID-METABOLISM;
   OXIDATIVE STRESS; ADIPOSE-TISSUE; MITOCHONDRIAL DISEASE
AB Obesity and the related metabolic syndrome have become a worldwide epidemic. Inactivity appears to be a primary causative factor in the pathogenesis of this obesity and metabolic syndrome. There are two possible, perhaps not mutually exclusive, events that may lead to intramyocellular lipid accumulation and mitochondrial dysfunction in patients with obesity. First, obesity, with high intake-associated lipid accumulation in muscle may interfere with cellular mitochondrial function through generation of reactive oxygen species leading to lipid membrane peroxidative injury and disruption of mitochondrial membrane-dependent enzymes. This in turn leads to impaired oxidative metabolism. Secondly, a primary defect in mitochondrial oxidative metabolism may be responsible for a reduction in fatty acid oxidation leading to intramyocellular lipid accumulation as a secondary event. Non-invasive techniques such as proton (H-1) and phosphorus (P-31) magnetic resonance spectroscopy, coupled with specific magnetic resonance imaging techniques, may facilitate the investigation of the effects of various ergometric interventions on the pathophysiology of obesity and the metabolic syndrome. Exercise has positive effects on glucose metabolism, aerobic metabolism, mitochondrial density, and respiratory chain proteins in patients with metabolic syndrome, and we propose that this may be due to the exercise effects on AMP kinase, and a prospective physiological mechanism for this benefit is presented. A physiological model of the effect of intramyocellular lipid accumulation on oxidative metabolism and insulin mediated glucose uptake is proposed.
C1 [Tein, Ingrid] Univ Toronto, Toronto Gen Hosp, Hosp Sick Children, Dept Pediat, Toronto, ON, Canada.
   [Tein, Ingrid] Univ Toronto, Toronto Gen Hosp, Hosp Sick Children, Dept Lab Med & Pathol, Toronto, ON, Canada.
   [Hamilton, Jill] Univ Toronto, Toronto Gen Hosp, Hosp Sick Children, Div Endocrinol, Toronto, ON, Canada.
   [Wells, Greg D.] Univ Toronto, Toronto Gen Hosp, Hosp Sick Children, Dept Anesthesia, Toronto, ON, Canada.
   [Noseworthy, Michael D.] McMaster Univ, Dept Elect & Comp Engn, Brain Body Inst, Hamilton, ON, Canada.
   [Noseworthy, Michael D.] McMaster Univ, Dept Med Phys, Brain Body Inst, Hamilton, ON, Canada.
   [Noseworthy, Michael D.] McMaster Univ, Dept Biomed Engn, Brain Body Inst, Hamilton, ON, Canada.
   [Tarnopolski, Mark] McMaster Univ, Med Ctr, Neuromuscular & Neurometab Clin, Hamilton, ON, Canada.
C3 University of Toronto; University Health Network Toronto; Toronto
   General Hospital; Hospital for Sick Children (SickKids); University of
   Toronto; Hospital for Sick Children (SickKids); University Health
   Network Toronto; Toronto General Hospital; University of Toronto;
   Hospital for Sick Children (SickKids); University Health Network
   Toronto; Toronto General Hospital; University of Toronto; Hospital for
   Sick Children (SickKids); University Health Network Toronto; Toronto
   General Hospital; McMaster University; McMaster University; McMaster
   University; McMaster University
RP Wells, GD (corresponding author), Hosp Sick Children, Div Resp Med, Rm 4534,555 Univ Ave, Toronto, ON M5G 1X8, Canada.
RI ; Noseworthy, Michael/B-2957-2011
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NR 102
TC 56
Z9 68
U1 0
U2 11
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
SN 0317-1671
EI 2057-0155
J9 CAN J NEUROL SCI
JI Can. J. Neurol. Sci.
PD MAR
PY 2008
VL 35
IS 1
BP 31
EP 40
DI 10.1017/S0317167100007538
PG 10
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 269RQ
UT WOS:000253667700006
PM 18380275
OA Bronze
DA 2025-06-11
ER

PT J
AU Bonifácio, KL
   Barbosa, DS
   Moreira, EG
   de Farias, CC
   Higachi, L
   Camargo, AEI
   Soares, JF
   Vargas, HO
   Nunes, SOV
   Berk, M
   Dodd, S
   Maes, M
AF Bonifacio, Kamila Landucci
   Barbosa, Decio Sabbatini
   Moreira, Estefania Gastaldello
   de Farias, Carine Coneglian
   Higachi, Luciana
   Iakmiu Camargo, Alissana Ester
   Soares, Janaina Favaro
   Vargas, Heber Odebrecht
   Vargas Nunes, Sandra Odebrecht
   Berk, Michael
   Dodd, Seetal
   Maes, Michael
TI Indices of insulin resistance and glucotoxicity are not associated with
   bipolar disorder or major depressive disorder, but are differently
   associated with inflammatory, oxidative and nitrosative biomarkers
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Insulin resistance; Depression; Mania; Bipolar disorder; Oxidative
   stress; Inflammation
ID METABOLIC SYNDROME COMPONENTS; CARDIOVASCULAR RISK-FACTORS;
   NECROSIS-FACTOR-ALPHA; PROTEIN PRODUCTS; URIC-ACID; STRESS; SMOKING;
   SENSITIVITY; HAPTOGLOBIN; MECHANISMS
AB Background. Insulin resistance (IR) is a key factor in diabetes mellitus, metabolic syndrome (MetS) and obesity and may occur in mood disorders and tobacco use disorder (TUD), where disturbances of immune-inflammatory, oxidative and nitrosative stress (10 & NS) pathways are important shared pathophysiological pathways.
   Methods: This study aimed to a) examine IR and beta-cell function as measured by the homeostasis model assessment of insulin resistance (HOMA-IR) and insulin sensitivity and 13 cell function (HOMA-B) and glucotoxicity (conceptualized as increased glucose levels versus lowered HOMA-B values) in 74 participants with major depressive disorder (MDD) and bipolar disorder, with and or without MetS and TUD, versus 46 healthy controls, and b) whether IR is associated with IO & NS biomarkers, including nitric oxide metabolites (NOx), lipid hydroperoxides (LOOH), plasma advanced oxidation protein products (AOPP), C-reactive protein (CRP), haptoglobin (Hp) and uric acid.
   Results: Mood disorders are not associated with changes in IR or glucotoxicity, although the number of mood episodes may increase IR. 47.8% of the variance in HOMA-IR is explained by AOPP and body mass index (BMI, both positively) and NOx, Hp and TUD (all inversely). 43.2% of the variance in HOMA-B is explained by NOx, Hp and age (all inversely associated) and higher BMI and sex. The glucotoxic index is strongly associated with NOx, Hp and BMI (positively), male gender and lower education.
   Limitations: This is a cross-sectional study and therefore we cannot draw firm conclusions on causal associations.
   Conclusions: Activated IO & NS pathways (especially increased Hp and NOx) increase glucotoxicity and exert very complex effects modulating IR. Mood disorders are not associated with increased IR.
C1 [Bonifacio, Kamila Landucci; Barbosa, Decio Sabbatini; de Farias, Carine Coneglian; Higachi, Luciana; Iakmiu Camargo, Alissana Ester; Soares, Janaina Favaro] Univ Estadual Londrina, Univ Hosp, Lab Graduat Res, Londrina, Parana, Brazil.
   [Maes, Michael] Chulalongkorn Univ, Dept Psychiat, Bangkok, Thailand.
   [Bonifacio, Kamila Landucci; Barbosa, Decio Sabbatini; Moreira, Estefania Gastaldello; de Farias, Carine Coneglian; Higachi, Luciana; Vargas Nunes, Sandra Odebrecht] Univ Estadual Londrina, Graduat Program Hlth Sci, Londrina, PR, Brazil.
   [Vargas, Heber Odebrecht] Univ Estadual Londrina, Hlth Sci Ctr, Dept Psychiat, Londrina, Parana, Brazil.
   [Berk, Michael; Dodd, Seetal; Maes, Michael] Deakin Univ, IMPACT Strateg Res Ctr, Sch Med, Barwon Hlth, Geelong, Vic, Australia.
   [Berk, Michael; Dodd, Seetal] Oygen, Natl Ctr Excellence Youth Mental Hlth, Parkville, Vic, Australia.
   [Berk, Michael; Dodd, Seetal] Univ Melbourne, Dept Psychiat, Melbourne, Vic, Australia.
   [Berk, Michael] Univ Melbourne, Florey Inst Neurosci & Mental Hlth, Melbourne, Vic, Australia.
   [Barbosa, Decio Sabbatini] Univ Estadual Londrina, Dept Clin Anal & Toxicol, Londrina, PR, Brazil.
C3 Universidade Estadual de Londrina; Chulalongkorn University;
   Universidade Estadual de Londrina; Universidade Estadual de Londrina;
   Deakin University; Barwon Health; Orygen, The National Centre of
   Excellence in Youth Mental Health; University of Melbourne; University
   of Melbourne; Florey Institute of Neuroscience & Mental Health;
   Universidade Estadual de Londrina
RP Maes, M (corresponding author), Chulalongkorn Univ, Dept Psychiat, Bangkok, Thailand.; Berk, M; Maes, M (corresponding author), Deakin Univ, IMPACT Strateg Res Ctr, Sch Med, Barwon Hlth, Geelong, Vic, Australia.; Berk, M (corresponding author), Oygen, Natl Ctr Excellence Youth Mental Hlth, Parkville, Vic, Australia.; Berk, M (corresponding author), Univ Melbourne, Dept Psychiat, Melbourne, Vic, Australia.; Berk, M (corresponding author), Univ Melbourne, Florey Inst Neurosci & Mental Hlth, Melbourne, Vic, Australia.
EM mikebe@barwonhealth.org.au; dr.michaelmaes@hotmail.com
RI Maes, Michael/B-8546-2011; Berk, Michael/AGH-9427-2022; Barbosa,
   Décio/AAE-6351-2019; Moreira, Estefania/AAC-5959-2019; Berk,
   Michael/M-7891-2013
OI Moreira, Estefania/0000-0001-8362-9557; Maes,
   Michael/0000-0002-2012-871X; Berk, Michael/0000-0002-5554-6946; Colman,
   Carine Coneglian de Farias/0000-0003-2967-3420
FU CNPq [203826/2015-9]; NHMRC [1059660]; Special Visiting Researcher (PVE)
   fellowship from Conselho Nacional de Pesquisa e Desenvolvimento at the
   Graduation Program in Health Sciences, UEL;  [404877/2013-3]
FX KLB is supported by CNPq, Scholarship 203826/2015-9. MB is supported by
   a NHMRC Senior Principal Research Fellowship 1059660. DSB and SOVN are
   senior fellows from Fundacao Araucaria. MM is supported by a Special
   Visiting Researcher (PVE) fellowship from Conselho Nacional de Pesquisa
   e Desenvolvimento at the Graduation Program in Health Sciences, UEL.
   This study was funded by grants from 404877/2013-3. The funding sources
   had no involvement in study design; and collection, analysis and
   interpretation of data; in the writing of the report; and in the
   decision to submit the article for publication.
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NR 75
TC 12
Z9 12
U1 1
U2 17
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD NOV
PY 2017
VL 222
BP 185
EP 194
DI 10.1016/j.jad.2017.07.010
PG 10
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA FD6SB
UT WOS:000407657100028
PM 28710952
DA 2025-06-11
ER

PT J
AU Akl, EM
   Fouad, NA
   Mahmoud, MS
   Khalil, KT
AF Akl, Essam M.
   Fouad, Nehad A.
   Mahmoud, Maram S.
   Khalil, Karem T.
TI Growth Differentiation Factor-15: One of the Missing Links between
   Psoriasis and Metabolic Syndrome
SO INDIAN DERMATOLOGY ONLINE JOURNAL
LA English
DT Article
DE Growth differentiation factor-15; metabolic syndrome; psoriasis
ID CARDIOVASCULAR RISK; PREVALENCE; GDF15; LEVEL
AB Background:Psoriasis is a chronic inflammatory condition of the skin that can be related to a variety of other conditions, including cardiovascular disease and metabolic syndrome. Growth differentiation factor-15 (GDF-15) is a cytokine that reacts to cellular stress. GDF-15 serum levels may have clinical uses in a variety of inflammatory and cardiovascular conditions. Objectives:To determine the levels of GDF-15 in the serum of patients with generalized plaque psoriasis (GPP) and its correlation with the metabolic syndrome. Patients and Methods:This case-control study included 50 patients with GPP and 50 age- and sex-matched healthy volunteers as controls. A general examination was performed, with a particular emphasis on measurements of body mass index, circumference of the waist, and blood pressure. Psoriasis severity was assessed using the Psoriasis Area and Severity Index (PASI) score. In addition, laboratory tests, including fasting blood sugar, lipid profile, and serum GDF-15 level measurement, were made. Results:Patients had significantly higher median GDF-15 levels compared to controls (P < 0.001). GDF-15 showed a substantial correlation with both disease duration and PASI score (P < 0.001 for each). GDF-15 levels were considerably greater in participants with metabolic syndrome compared with those without (P = 0.01). Limitation:The relatively small sample size could be a disadvantage and drawback of the study. Conclusion:Serum GDF-15 levels are linked to the severity of psoriasis and the associated metabolic disorders.
C1 [Akl, Essam M.; Khalil, Karem T.] Benha Univ, Dept Dermatol Venereol & Androl, Fac Med, Banha, Al Qalyubia Gov, Egypt.
   [Fouad, Nehad A.] Benha Univ, Dept Med Microbiol & Immunol, Fac Med, Banha, Al Qalyubia Gov, Egypt.
   [Mahmoud, Maram S.] Benha Univ, Fac Med, Banha, Al Qalyubia Gov, Egypt.
C3 Egyptian Knowledge Bank (EKB); Benha University; Egyptian Knowledge Bank
   (EKB); Benha University; Egyptian Knowledge Bank (EKB); Benha University
RP Khalil, KT (corresponding author), Benha Univ, Dept Dermatol Venereol & Androl, Fac Med, Banha, Al Qalyubia Gov, Egypt.
EM Karem.khalil@fmed.bu.edu.eg
RI Akl, Essam/AAG-6230-2019
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NR 30
TC 1
Z9 1
U1 0
U2 0
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, Maharashtra, INDIA
SN 2229-5178
EI 2249-5673
J9 INDIAN DERMATOL ONL
JI Indian Dermatol. Online J.
PD MAY-JUN
PY 2025
VL 16
IS 3
BP 397
EP 401
DI 10.4103/idoj.idoj_546_24
PG 5
WC Dermatology
WE Emerging Sources Citation Index (ESCI)
SC Dermatology
GA 1ZU6D
UT WOS:001477551200025
PM 40395585
DA 2025-06-11
ER

PT J
AU Ingram, JR
AF Ingram, John R.
TI The epidemiology of hidradenitis suppurativa
SO BRITISH JOURNAL OF DERMATOLOGY
LA English
DT Review
ID INFLAMMATORY-BOWEL-DISEASE; METABOLIC SYNDROME; GAMMA-SECRETASE;
   POPULATION; PREVALENCE; RISK
AB Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease defined clinically by multiple, painful inflammatory lesions occurring predominantly in flexural sites. Onset is typically soon after puberty; however, it remains unknown whether the menopause induces remission. In North American and European patients with HS the female-to-male ratio is approximately 3 : 1 but the ratio is 1 : 2 in South Korean patients. It may be that some elements of HS epidemiology cannot be generalized across all populations. Elements of HS epidemiology in the USA and Europe are well established, including strong associations with obesity and smoking, which may increase disease severity. There are associations between HS and other cardiovascular disease (CVD) risk factors, including type 2 diabetes and metabolic syndrome. People with HS have double the risk of death from CVD compared with those without HS and 1 center dot 5 times the risk compared with patients with psoriasis. Depression and anxiety are associated with HS and completed suicide rates in those with HS are more than double the rates in controls. Associations exist between HS and other chronic inflammatory conditions, particularly inflammatory bowel disease and inflammatory arthritis. Case-control studies demonstrate associations with pilonidal sinus, polycystic ovary syndrome, Down syndrome, obstructive sleep apnoea and pyoderma gangrenosum. Population-based studies using routinely collected healthcare data from the USA estimate a prevalence of 0 center dot 1%, suggesting HS is relatively uncommon. European studies include undiagnosed patients and typically estimate prevalence of 1% or more, suggesting a common condition. Resolving the controversy surrounding a greater than 10-fold difference in HS prevalence estimates remains a high priority.
C1 [Ingram, John R.] Cardiff Univ, Div Infect & Immun, Dept Dermatol & Acad Wound Healing, Cardiff CF14 4XN, Wales.
C3 Cardiff University
RP Ingram, JR (corresponding author), Cardiff Univ, Div Infect & Immun, Dept Dermatol & Acad Wound Healing, Cardiff CF14 4XN, Wales.
EM ingramjr@cardiff.ac.uk
OI Ingram, John R/0000-0002-5257-1142
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NR 62
TC 143
Z9 146
U1 0
U2 7
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0007-0963
EI 1365-2133
J9 BRIT J DERMATOL
JI Br. J. Dermatol.
PD DEC
PY 2020
VL 183
IS 6
BP 990
EP 998
DI 10.1111/bjd.19435
EA SEP 2020
PG 9
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA PE3BV
UT WOS:000566365300001
PM 32880911
OA Green Accepted, hybrid
DA 2025-06-11
ER

PT J
AU Ghattamaneni, NKR
   Sharma, A
   Panchal, SK
   Brown, L
AF Ghattamaneni, Naga K. R.
   Sharma, Ashwini
   Panchal, Sunil K.
   Brown, Lindsay
TI Pelargonidin 3-glucoside-enriched strawberry attenuates symptoms of
   DSS-induced inflammatory bowel disease and diet-induced metabolic
   syndrome in rats
SO EUROPEAN JOURNAL OF NUTRITION
LA English
DT Article
DE Inflammatory bowel disease; Metabolic syndrome; Anthocyanin;
   Pelargonidin 3-glucoside; Inflammation
ID OXIDATIVE STRESS; CYANIDIN 3-GLUCOSIDE; INSULIN-RESISTANCE;
   HIGH-CARBOHYDRATE; HEALTH-BENEFITS; ANTHOCYANINS; EXTRACT; OBESITY;
   ADIPOGENESIS; CONSUMPTION
AB Purpose To determine whether the anthocyanin, pelargonidin 3-glucoside (P3G), attenuates symptoms of inflammatory bowel disease (IBD) and metabolic syndrome in rats. Methods We tested P3G-enriched strawberry in two models of chronic inflammation in rats, chronic IBD induced by 0.5% dextran sodium sulphate in the drinking water for 12 weeks (D) and metabolic syndrome induced by a high-carbohydrate, high-fat diet (H) for 16 weeks. P3G-enriched strawberry was added to the diet for the final 6 weeks in IBD rats (DP) or 8 weeks in H rats (HP) to provide a dose of 8 mg P3G/kg/day. Results D rats had marked diarrhoea, bloody stools, erosion of mucosal epithelium, crypt atrophy, loss of villi and goblet cells, and inflammatory cell infiltration. These symptoms were reversed by P3G with healthy stools and mucosal lining of ileum and colon including increased villi, crypts and goblet cells and reduced inflammation. H rats developed hypertension, dyslipidaemia, central obesity, increased ventricular stiffness, cardiac and liver inflammation, and steatosis. P3G treatment in H rats improved systolic blood pressure, ventricular stiffness, and cardiac and liver structure, and reduced abdominal fat, abdominal circumference and body weight gain. Conclusions Our study indicates that dietary P3G decreased inflammation to decrease the symptoms of IBD, and to improve cardiovascular, liver and metabolic functions in metabolic syndrome.
C1 [Ghattamaneni, Naga K. R.; Sharma, Ashwini; Panchal, Sunil K.; Brown, Lindsay] Univ Southern Queensland, Funct Foods Res Grp, Toowoomba, Qld 4350, Australia.
   [Sharma, Ashwini; Brown, Lindsay] Univ Southern Queensland, Sch Hlth & Wellbeing, Toowoomba, Qld 4350, Australia.
C3 University of Southern Queensland; University of Southern Queensland
RP Brown, L (corresponding author), Univ Southern Queensland, Funct Foods Res Grp, Toowoomba, Qld 4350, Australia.; Brown, L (corresponding author), Univ Southern Queensland, Sch Hlth & Wellbeing, Toowoomba, Qld 4350, Australia.
EM Lindsay.Brown@usq.edu.au
RI Ghattamaneni, Naga/AAL-3746-2020
OI Panchal, Sunil K/0000-0001-5464-3376; Ghattamaneni, Naga Koteswara
   Rao/0000-0003-0838-390X
FU University of Southern Queensland Research and Innovation Division
FX Rat urine samples were analysed for sugars at the Central Analytical
   Research Facility (CARF) of the Queensland University of Technology,
   Gardens Point, Brisbane, with the assistance of Dr. Rajesh Gupta. Gut
   histology was performed at the CARF, Queensland University of
   Technology, Kelvin Grove, Brisbane, with the assistance of Ms Felicity
   Lawrence. We thank Brian Bynon, School of Veterinary Sciences, The
   University of Queensland, Gatton, for the plasma analyses. This work was
   supported by funding received from the University of Southern Queensland
   Research and Innovation Division.
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NR 62
TC 34
Z9 35
U1 2
U2 28
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1436-6207
EI 1436-6215
J9 EUR J NUTR
JI Eur. J. Nutr.
PD OCT
PY 2020
VL 59
IS 7
BP 2905
EP 2918
DI 10.1007/s00394-019-02130-1
EA NOV 2019
PG 14
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA NQ3JI
UT WOS:000494785600001
PM 31696323
DA 2025-06-11
ER

PT J
AU Carvalho, APSD
   Uehara, SK
   Netto, JFN
   Rosa, G
AF Soares de Oliveira Carvalho, Anna Paula
   Uehara, Sofia Kimi
   Nogueria Netto, Jose Firmino
   Rosa, Glorimar
TI Hypocaloric diet associated with the consumption of jam enriched with
   microencapsulated fish oil decreases insulin resistance
SO NUTRICION HOSPITALARIA
LA English
DT Article
DE Metabolic syndrome; Fish oil; Insulin resistance; Hypocaloric diet;
   Microencapsulation
ID POLYUNSATURATED FATTY-ACIDS; CARDIOVASCULAR-DISEASE RISK; METABOLIC
   SYNDROME; EICOSAPENTAENOIC ACID; OXIDATIVE STRESS; ADIPONECTIN;
   SENSITIVITY; SECRETION; GLUCOSE; PEOPLE
AB Background: The metabolic syndrome is related to the increase in cardiovascular diseases. Polyunsaturated fatty acids from fish oil help in reducing cardiovascular risk factors and are natural bindings of PPAR gamma 2.
   Objective: To evaluate the impact of hypocaloric diet associated with microencapsulated fish oil supplementation in women with metabolic syndrome.
   Methods: We conducted a randomized, single-blind and placebo-controlled clinical trial with adult women who presented metabolic syndrome (n = 30) for 90 days. The volunteers were divided into two groups: placebo group (n = 15) and microencapsulated fish oil group (n = 15) (3 g/day of microencapsulated fish oil containing 0.41 g/day of eicosapentaenoic acid and decosahexaneoic acid). Anthropometric, body composition, clinical and, laboratory parameters were assessed before and after the intervention. Paired t-test was used for comparisons Within groups and Student's t-test for comparison between groups. We considered p < 0.05 as significant values.
   Results: The comparison between groups revealed a significant reduction of blood glucose, insulinemia and the homeostasis model assessment in the microencapsulated fish oil group after 90 days, as opposed to the placebo group. We also observed reduction of the systolic arterial pressure in the microencapsulated fish oil group.
   Conclusion: A hypocaloric diet associated with the consumption of microencapsulated fish oil was effective in reducing blood glucose, insulinemia and insulin resistance in women with MS.
C1 [Soares de Oliveira Carvalho, Anna Paula] Univ Fed Rio de Janeiro, Grad Program Med Cardiol, Sch Med, Rio De Janeiro, RJ, Brazil.
   [Uehara, Sofia Kimi] Univ Fed Rio de Janeiro, Grad Program Nutr, Josue de Castro Inst Nutr, Rio De Janeiro, RJ, Brazil.
   [Nogueria Netto, Jose Firmino] Univ Estado Rio De Janeiro, Dept Physiol Sci, Inst Biol, Rio De Janeiro, RJ, Brazil.
   [Rosa, Glorimar] Univ Fed Rio de Janeiro, Dept Nutr & Diet, Josue de Castro Inst Nutr, Rio De Janeiro, RJ, Brazil.
C3 Universidade Federal do Rio de Janeiro; Universidade Federal do Rio de
   Janeiro; Universidade do Estado do Rio de Janeiro; Universidade Federal
   do Rio de Janeiro
RP Rosa, G (corresponding author), Inst Nutr Josue de Castro, Dept Nutr & Dietet, Av Carlos Chagas Filho 373,Bloco J,2 Andar, BR-21941590 Rio De Janeiro, RJ, Brazil.
EM glorimar@nutricao.ufrj.br
RI Rosa, Glorimar/HJI-7004-2023; Azevedo De Carvalho, Anna
   Paula/GPP-3985-2022
OI Azevedo De Carvalho, Anna Paula/0000-0001-9258-5947
FU FAPERJ (Research Funding Agency of the State of Rio de Janeiro); CAPES
   (Government agency linked to the Brazilian Ministry of Education in
   charge of promoting high standards for post-graduate courses in Brazil);
   CNPq (National Council for Scientific and Technological Development)
FX We are especially thankful to FAPERJ (Research Funding Agency of the
   State of Rio de Janeiro); CAPES (Government agency linked to the
   Brazilian Ministry of Education in charge of promoting high standards
   for post-graduate courses in Brazil); and CNPq (National Council for
   Scientific and Technological Development) for their financial support to
   carry out this study.
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NR 42
TC 6
Z9 6
U1 0
U2 3
PU ARAN EDICIONES, S L
PI MADRID
PA C/ CASTELLO, 128, 1O, MADRID, 28006, SPAIN
SN 0212-1611
EI 1699-5198
J9 NUTR HOSP
JI Nutr. Hosp.
PD MAY
PY 2014
VL 29
IS 5
BP 1103
EP 1108
DI 10.3305/nh.2014.29.5.6654
PG 6
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA AJ5JD
UT WOS:000337717600020
PM 24951991
DA 2025-06-11
ER

PT J
AU Jenko-Praznikar, Z
   Petelin, A
   Jurdana, M
   Ziberna, L
AF Jenko-Praznikar, Zala
   Petelin, Ana
   Jurdana, Mihaela
   Ziberna, Lauro
TI Serum bilirubin levels are lower in overweight asymptomatic middle-aged
   adults: An early indicator of metabolic syndrome?
SO METABOLISM-CLINICAL AND EXPERIMENTAL
LA English
DT Article
DE Asymptomatic individuals; Biomarker; Obesity; Pre-disease; Primary
   prevention
ID OXIDATIVE STRESS; INSULIN-RESISTANCE; ANTIOXIDANT DEFENSES; ENDOTHELIAL
   FUNCTION; GILBERT-SYNDROME; ADIPOSE-TISSUE; YOUNG-ADULTS; OBESITY;
   HEART; RISK
AB Objective. Low levels of bilirubin have recently been associated with obesity, diabetes mellitus, and metabolic syndrome. Here, we hypothesized that serum bilirubin levels might be already altered in overweight asymptomatic middle-aged individuals before full development of the metabolic syndrome.
   Methods. Healthy nonsmoking adults aged 25-49 (64 women and 32 men) participated in this cross-sectional study. All participants who reported stable weight within the last three months underwent standard anthropomorphological measurements of body composition, blood pressure measurements, aerobic and anaerobic capabilities assessment, dietary intake evaluation, and fasting serological measurements of total and direct bilirubin, glucose, insulin, triglycerides, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and C-reactive protein. Participants were divided into normal-weight and overweight groups. Linear correlation and multiple regression analyses were used to examine the association of serum bilirubin levels with all metabolic syndrome risk factor changes.
   Results. Serum bilirubin levels were lower in overweight healthy individuals of both sexes, and were negatively associated with abdominal obesity, insulin resistance, fasting glucose, fasting insulin, fasting triglycerides, total cholesterol, low-density lipoprotein cholesterol, and C-reactive protein levels but positively associated with aerobic body capabilities.
   Conclusion. Our findings suggest that serum bilirubin levels have the potential to be employed as an early biomarker for indicating asymptomatic individuals at increased risk of developing metabolic syndrome. (C) 2013 Elsevier Inc. All rights reserved.
C1 [Jenko-Praznikar, Zala; Petelin, Ana; Jurdana, Mihaela] Univ Primorska, Fac Hlth Sci, Izola 6310, Slovenia.
   [Ziberna, Lauro] Univ Trieste, Dept Life Sci, I-34127 Trieste, Italy.
C3 University of Primorska; University of Trieste
RP Ziberna, L (corresponding author), Univ Trieste, Dept Life Sci, Via L Giorgieri 1, I-34127 Trieste, Italy.
EM lziberna@units.it
RI Ziberna, Lovro/A-1107-2010; Petelin, Ana/GLV-1610-2022; Jenko Praznikar,
   Zala/KVX-9901-2024
OI Ziberna, Lovro/0000-0002-2840-5208; Petelin, Ana/0000-0002-5557-5974;
   Jenko Praznikar, Zala/0000-0002-5217-8754
FU Faculty of Health Sciences, University of Primorska; Slovenian Research
   Agency [J3-4211, J3-4259, J3-2277]; European Regional Development Fund,
   Cross-Border Cooperation Italy-Slovenia Programme (EU strategic project
   TRANS2CARE)
FX Funding was received from the Faculty of Health Sciences, University of
   Primorska, for the project entitled "A multidisciplinary approach in the
   treatment of obesity", from the Slovenian Research Agency (Research
   Projects J3-4211, J3-4259, J3-2277), and from the European Regional
   Development Fund, Cross-Border Cooperation Italy-Slovenia Programme
   2007-2013 (EU strategic project TRANS2CARE).
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NR 38
TC 51
Z9 55
U1 1
U2 14
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0026-0495
EI 1532-8600
J9 METABOLISM
JI Metab.-Clin. Exp.
PD JUL
PY 2013
VL 62
IS 7
BP 976
EP 985
DI 10.1016/j.metabol.2013.01.011
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 175IT
UT WOS:000321225100010
PM 23414908
DA 2025-06-11
ER

PT J
AU Takeshita, J
   Grewal, S
   Langan, SM
   Mehta, NN
   Ogdie, A
   Van Voorhees, AS
   Gelfand, JM
AF Takeshita, Junko
   Grewal, Sungat
   Langan, Sinead M.
   Mehta, Nehal N.
   Ogdie, Alexis
   Van Voorhees, Abby S.
   Gelfand, Joel M.
TI Psoriasis and comorbid diseases Epidemiology
SO JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
LA English
DT Review
DE cardiovascular disease; chronic kidney disease; comorbidities; Crohn's
   disease; depression; metabolic syndrome; nonalcoholic fatty liver
   disease; psoriasis; psoriatic arthritis; lymphoma; infection
ID POPULATION-BASED-COHORT; CARDIOVASCULAR RISK STRENGTH; CHOLESTEROL
   EFFLUX CAPACITY; PLATELET-DERIVED MICROPARTICLES; CAUSE-SPECIFIC
   MORTALITY; STRESSFUL LIFE EVENTS; HONG-KONG CHINESE; GENOME-WIDE SCAN;
   METABOLIC SYNDROME; US WOMEN
AB Psoriasis is a common chronic inflammatory disease of the skin that is increasingly being recognized as a systemic inflammatory disorder. Psoriatic arthritis is a well-known comorbidity of psoriasis. A rapidly expanding body of literature in various populations and settings supports additional associations between psoriasis and cardiometabolic diseases, gastrointestinal diseases, kidney disease, malignancy, infection, and mood disorders. The pathogenesis of comorbid disease in patients with psoriasis remains unknown; however, shared inflammatory pathways, cellularmediators, genetic susceptibility, and common risk factors are hypothesized to be contributing elements. As additional psoriasis comorbidities continue to emerge, education of health care providers is essential to ensuring comprehensive medical care for patients with psoriasis.
C1 [Takeshita, Junko; Grewal, Sungat; Gelfand, Joel M.] Univ Penn, Perelman Sch Med, Dept Dermatol, Philadelphia, PA 19104 USA.
   [Takeshita, Junko; Ogdie, Alexis; Gelfand, Joel M.] Univ Penn, Ctr Clin Epidemiol & Biostat, Perelman Sch Med, Dept Epidemiol & Biostat, Philadelphia, PA 19104 USA.
   [Ogdie, Alexis] Univ Penn, Perelman Sch Med, Div Rheumatol, Philadelphia, PA 19104 USA.
   [Langan, Sinead M.] London Sch Hyg & Trop Med, London, England.
   [Langan, Sinead M.] St Johns Inst Dermatol, London, England.
   [Mehta, Nehal N.] NHLBI, Bldg 10, Bethesda, MD 20892 USA.
   [Van Voorhees, Abby S.] Eastern Virginia Med Sch, Dept Dermatol, Norfolk, VA 23501 USA.
C3 University of Pennsylvania; University of Pennsylvania; University of
   Pennsylvania; University of London; London School of Hygiene & Tropical
   Medicine; University of London; King's College London; National
   Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood
   Institute (NHLBI); Eastern Virginia Medical School
RP Takeshita, J (corresponding author), Univ Penn, Perelman Ctr Adv Med, Perelman Sch Med, Dept Dermatol, 3400 Civ Ctr Blvd,7th Floor,South Tower,Off 728, Philadelphia, PA 19104 USA.
EM Junko.Takeshita@uphs.upenn.edu
RI Mehta, Nehal/W-4669-2019
OI Langan, Sinead/0000-0002-7022-7441; Gelfand, Joel/0000-0003-3480-2661
FU NIAMS NIH HHS [T32 AR007465, K23 AR063764, K23 AR068433, K24 AR064310]
   Funding Source: Medline; Intramural NIH HHS [ZIA HL006193] Funding
   Source: Medline; Department of Health [NIHR/CS/010/014] Funding Source:
   Medline
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NR 158
TC 790
Z9 838
U1 16
U2 147
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0190-9622
J9 J AM ACAD DERMATOL
JI J. Am. Acad. Dermatol.
PD MAR
PY 2017
VL 76
IS 3
BP 377
EP 390
DI 10.1016/j.jaad.2016.07.064
PG 14
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA ES0KG
UT WOS:000399214700010
PM 28212759
OA Green Submitted, Green Accepted, Green Published, hybrid
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Lima, PA
   Sampaio, LPD
   Damasceno, NRT
AF Lima, Patricia Azevedo
   de Brito Sampaio, Leticia Pereira
   Teixeira Damasceno, Nagila Raquel
TI Ketogenic diet in epileptic children: impact on lipoproteins and
   oxidative stress
SO NUTRITIONAL NEUROSCIENCE
LA English
DT Review
DE Ketogenic diet; Epilepsy; Lipid metabolism; Dyslipidemias; Low-density
   lipoprotein; Oxidative stress
ID LOW-DENSITY-LIPOPROTEIN; LDL PARTICLE-SIZE; RISK-FACTORS; MANAGEMENT;
   CHILDHOOD; NRF2; ADOLESCENTS; DISEASE; SYSTEM; GROWTH
AB Objectives: Ketogenic diet (KD) is an important therapy used in the control of drug-refractory seizures. The major goal of this review is to update the knowledge about the adverse effects of KD on lipoproteins, lipid profile, and cardiometabolic risk.
   Methods: Articles on the effect of the KD on plasma lipoproteins of children and adolescents with refractory epilepsy, which were published in the past 15 years and indexed in the PubMed and MedLine databases, were included.
   Results: Dyslipidemia was recurrent in children, and adolescents treated with KD. Evidence suggests that hypercholesterolemia promotes structural modifications in low-density lipoprotein particles. Such modifications possibly favor oxidative processes and contribute to changes in the size of lipoproteins, particularly related to small and denser LDL. However, oxidative modifications in LDL of children on KD are not described in the literature.
   Discussion: The positive effects of KD on the health of children and adolescents with refractory epilepsy are unquestionable. Conversely, this positive role is associated with significant and negative changes in lipid metabolism. Moreover, the positive effects are possibly related to oxidative reactions and unbalance of antioxidants that can contribute to an increased cardiometabolic risk. Therefore, this review invites clinicians and researchers to investigate the lipid and oxidative metabolism in their clinical practice and trials, respectively.
C1 [Lima, Patricia Azevedo] Univ Sao Paulo, Dept Nutr, BR-05508 Sao Paulo, Brazil.
   [de Brito Sampaio, Leticia Pereira] Univ Sao Paulo, Neuropediat, Childrens Inst, Hosp Clin,Sch Med, BR-05508 Sao Paulo, Brazil.
   [Teixeira Damasceno, Nagila Raquel] Univ Sao Paulo, Dept Nutr, Sch Publ Hlth, BR-05508 Sao Paulo, Brazil.
C3 Universidade de Sao Paulo; Universidade de Sao Paulo; Universidade de
   Sao Paulo
RP Lima, PA (corresponding author), Univ Sao Paulo, Dept Nutr, BR-05508 Sao Paulo, Brazil.
EM patricia.azlima@yahoo.com.br
RI SAMPAIO, LETICIA/J-2994-2016; Masuda, Patricia/ABE-1209-2021; Damasceno,
   Nagila/D-9816-2012
OI Damasceno, Nagila/0000-0002-9332-7816
FU State of Sao Paulo Research Foundation (FAPESP) [12/03775-0,
   14/26094-4]; National Institute for Science and Technology of Complex
   Fluids (INCT-FCx-USP); Fundacao de Amparo a Pesquisa do Estado de Sao
   Paulo (FAPESP) [12/03775-0, 14/26094-4] Funding Source: FAPESP
FX The authors acknowledge the financial support from the State of Sao
   Paulo Research Foundation (FAPESP # 12/03775-0 and 14/26094-4), National
   Institute for Science and Technology of Complex Fluids (INCT-FCx-USP)
   and Group for Research on Complex Fluids (NAP-FCx-USP).
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NR 55
TC 15
Z9 19
U1 0
U2 18
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1028-415X
EI 1476-8305
J9 NUTR NEUROSCI
JI Nutr. Neurosci.
PD NOV
PY 2015
VL 18
IS 8
BP 337
EP 344
DI 10.1179/1476830515Y.0000000036
PG 8
WC Neurosciences; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Nutrition & Dietetics
GA CZ4WB
UT WOS:000367102400001
PM 26177187
DA 2025-06-11
ER

PT J
AU Orgah, JO
   He, S
   Wang, YL
   Jiang, MM
   Wang, YF
   Orgah, EA
   Duan, YJ
   Zhao, BC
   Zhang, BL
   Han, JH
   Zhu, Y
AF Orgah, John O.
   He, Shuang
   Wang, Yule
   Jiang, Miao Miao
   Wang, Yuefei
   Orgah, Emmanuel A.
   Duan, Yajun
   Zhao, Buchang
   Zhang, Boli
   Han, Jihong
   Zhu, Yan
TI Pharmacological potential of the combination of Salvia
   miltiorrhiza (Danshen) and Carthamus tinctorius (Honghua) for
   diabetes mellitus and its cardiovascular complications
SO PHARMACOLOGICAL RESEARCH
LA English
DT Review
DE Metabolic syndrome; Type 2 diabetes; Cardiovascular dysfunction; Salvia
   miltiorrhiza; Carthamus tinctorius; Danhong injection
ID PERFORMANCE LIQUID-CHROMATOGRAPHY; CEREBRAL-ISCHEMIA-REPERFUSION;
   BLOOD-BRAIN-BARRIER; DANHONG INJECTION; METABOLIC SYNDROME;
   HYDROXYSAFFLOR-YELLOW; INSULIN-RESISTANCE; ACID-B; CHINESE MEDICINE;
   MYOCARDIAL-INFARCTION
AB Metabolic syndrome, such as diabetes mellitus, obesity, atherosclerosis, and high blood pressure (HBP), are closely linked pathophysiologically. However, current monotherapies for metabolic syndrome fail to target the multifactorial pathology via multiple mechanisms, as well as resolving the dysfunctionality of the cells and organs of the body. We aimed to provide a comprehensive and up-to-date review of the pharmacological advances, therapeutic potential, and phytochemistry of Salvia miltiorrhiza, Carthamus tinctorius, and Danhong injection (DHI). We discussed the molecular mechanisms of the bioactive constituents relating to diabetes mellitus and metabolic disease for further research and drug development. Interestingly, Salvia miltiorrhiza, Carthamus tinctorius, and DHI have anti-inflammatory, anti-glycemic, anti-thrombotic, and anti-cancer properties; and they mainly act by targeting the dysfunctional vasculatures including the inflammatory components of the disease to provide vascular repair as well as resolving oxidative stress. The major bioactive chemical constituents of these plants include polyphenolic acids, diterpene compounds, carthamin, and hydroxysafflor yellow A. Treatment of diabetes mellitus and its associated cardiovascular complication requires a comprehensive approach involving the use of appropriate traditional Chinese medicine formula. Danshen, Honghua, and DHI target the multiple risk factors regulating the physiologic function of the body and restore normalcy, apart from the traditional advice on exercise and diet control as treatment options in a metabolic syndrome patient.
C1 [Orgah, John O.; He, Shuang; Wang, Yule; Jiang, Miao Miao; Wang, Yuefei; Zhao, Buchang; Zhang, Boli; Zhu, Yan] Tianjin Univ Tradit Chinese Med, State Key Lab Component Based Chinese Med, Beihua South Rd, Tianjin 301617, Peoples R China.
   [Orgah, John O.; He, Shuang; Wang, Yule; Jiang, Miao Miao; Wang, Yuefei; Zhu, Yan] Tianjin Int Joint Acad Biotechnol & Med, TEDA, Res & Dev Ctr TCM, 220 Donging Rd, Tianjin 300457, Peoples R China.
   [Orgah, Emmanuel A.] Nigeria Nat Med Dev Agcy, 9 Kofo Abayomi St, Victoria Isl Logos, Nigeria.
   [Duan, Yajun; Han, Jihong] Nankai Univ, Minist Educ, Key Lab Bioact Mat, Coll Lye Sci,Key Lab Med Chem Biol, Tianjin 300193, Peoples R China.
   [Duan, Yajun; Han, Jihong] Hefei Univ Technol, Coll Biomed Engn, Hefei 230009, Peoples R China.
C3 Tianjin University of Traditional Chinese Medicine; Tianjin
   International Joint Academy of Biomedicine; Ministry of Education -
   China; Nankai University; Hefei University of Technology
RP Zhu, Y (corresponding author), Tianjin Univ Tradit Chinese Med, State Key Lab Component Based Chinese Med, Beihua South Rd, Tianjin 301617, Peoples R China.
EM yanzhu.harvard@iCloud.com
RI Zhu, Yan/A-1548-2017; Wang, yule/HLP-6351-2023; Wang,
   Yuefei/I-1985-2018; He, Shuang/AEG-2161-2022; Duan, Yajun/LJK-9029-2024;
   Orgah, John/Q-7645-2019
OI Wang, Yule/0000-0003-1079-8231
FU National Science Foundation of China [81873037, 81830112]; Major
   National Science and Technology Projects [2018YFC1704502]
FX This project is supported by the grands from National Science Foundation
   of China (81873037, 81830112); and Major National Science and Technology
   Projects (2018YFC1704502).
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NR 156
TC 71
Z9 79
U1 7
U2 72
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 1043-6618
EI 1096-1186
J9 PHARMACOL RES
JI Pharmacol. Res.
PD MAR
PY 2020
VL 153
AR 104654
DI 10.1016/j.phrs.2020.104654
PG 13
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA KW9PM
UT WOS:000521515600006
PM 31945473
DA 2025-06-11
ER

PT J
AU Lotti, S
   Pagliai, G
   Colombini, B
   Sofi, F
   Dinu, M
AF Lotti, Sofia
   Pagliai, Giuditta
   Colombini, Barbara
   Sofi, Francesco
   Dinu, Monica
TI Chronotype Differences in Energy Intake, Cardiometabolic Risk
   Parameters, Cancer, and Depression: A Systematic Review with
   Meta-Analysis of Observational Studies
SO ADVANCES IN NUTRITION
LA English
DT Review
DE chronotype; health; energy intake; risk factors; meta-analysis
ID EVENINGNESS QUESTIONNAIRE SCORE; CIRCADIAN PREFERENCE; BREAST-CANCER;
   FOOD-INTAKE; SLEEP; ASSOCIATIONS; WORK; DISORDERS; DISEASES; COHORT
AB Chronotype is a behavioral manifestation of the internal circadian clock system. It refers to the specific activity-rest preference of an individual over a 24-h period and can be assessed using different methodologies that classify individuals into morning or evening chronotype. In recent years, several studies have suggested a relation between individual chronotype, eating habits, and the risk of developing obesity and other conditions. Our aim was to evaluate the association between chronotype, energy intake, and health status through a meta-analytic approach. A comprehensive search of MEDLINE, Embase, Scopus, Web of Science, and Cochrane Database was conducted. Observational studies that reported a measure of association between chronotype, energy intake, and health indicators were considered eligible. Overall, 39 observational studies (37 cross-sect ional studies, 2 prospective cohort studies) were included in the systematic review, with a total of 377,797 subjects. By comparing morning and evening subjects, pooled analyses of cross-sectional studies showed significantly (P < 0.001) higher concentrations of blood glucose [mean difference (MD): 7.82; 95% CI: 3.18, 12.45], glycated hemoglobin (MD: 7.64; 95% CI: 3.08, 12.21), LDL cholesterol (MD: 13.69; 95% CI: 6.84, 20.54), and trig lycerides (MD: 12.62; 95% CI: 0.90, 2435) in evening subjects. Furthermore, an association between evening type and the risk of diabetes (OR: 130; 95% CI: 1.20, 1.41), cancer (OR: 1.18; 95% CI: 1.08, 130), and depression (OR: 1.86; 95% CI: 1.20, 2.88) was reported. Regarding the other outcomes examined, no significant differences were observed between the groups in terms of energy intake, anthropometric parameters, blood pressure, insulin, total and HDL cholesterol, and hypertension risk. In conclusion, evening chronotype was associated with a worse cardiometabolic risk profile and higher risk of diabetes, cancer, and depression. Further studies are needed to confirm these results and to better elucidate the interplay between chronotype, nutrition, and health status.
C1 [Lotti, Sofia; Pagliai, Giuditta; Colombini, Barbara; Sofi, Francesco; Dinu, Monica] Univ Florence, Dept Expt & Clin Med, Florence, Italy.
   [Sofi, Francesco] Careggi Univ Hosp, Unit Clin Nutr, Florence, Italy.
C3 University of Florence; University of Florence; Azienda Ospedaliero
   Universitaria Careggi
RP Lotti, S (corresponding author), Univ Florence, Dept Expt & Clin Med, Florence, Italy.
EM sofia.lotti@unifi.it
RI Colombini, Barbara/AAG-3272-2020; Dinu, Monica/I-4864-2017; Sofi,
   Francesco/J-3941-2016; Pagliai, Giuditta/K-9592-2016
OI Dinu, Monica/0000-0003-1687-2527; COLOMBINI,
   Barbara/0000-0003-1397-9791; Lotti, Sofia/0000-0001-9288-5683; Sofi,
   Francesco/0000-0001-7113-7424; Pagliai, Giuditta/0000-0002-2177-2857
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NR 61
TC 59
Z9 60
U1 2
U2 32
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 2161-8313
EI 2156-5376
J9 ADV NUTR
JI Adv. Nutr.
PD FEB 1
PY 2022
VL 13
IS 1
BP 269
EP 281
DI 10.1093/advances/nmab115
EA OCT 2021
PG 13
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nutrition & Dietetics
GA YW1BK
UT WOS:000753155400018
PM 34549270
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Agagündüz, D
   Yilmaz, B
   Cemali, Ö
   Simat, V
   Akkus, G
   Kulawik, P
   Ozogul, F
AF Agagunduz, Duygu
   Yilmaz, Birsen
   Cemali, Ozge
   Simat, Vida
   Akkus, Gamze
   Kulawik, Piotr
   Ozogul, Fatih
TI Impact of dairy food products on type 2 diabetes: Gut-pancreas axis for
   lower glucose level
SO TRENDS IN FOOD SCIENCE & TECHNOLOGY
LA English
DT Article
DE Dairy; Diabetes; Milk; Yogurt; Probiotic; Gut; Pancreas; Blood sugar
ID DOSE-RESPONSE METAANALYSIS; INSULIN-RESISTANCE SYNDROME; FERMENTED MILK
   KEFIR; BODY-WEIGHT; METABOLIC SYNDROME; FATTY-ACIDS; CALCIUM
   SUPPLEMENTATION; PROSPECTIVE ASSOCIATION; DIETARY-GUIDELINES; GLYCEMIC
   CONTROL
AB Background: Insulin resistance or inadequate pancreatic insulin secretion leads to high blood sugar levels. This is a key characteristic of type 2 diabetes mellitus (T2DM)- a noncommunicable disease. In recent studies, it has been suggested that dairy food products may have favorable impact on type 2 diabetes (T2DM) through the gut- pancreas axis, potentially leading to lower glucose levels. The gut-pancreas axis refers to communication between the gastrointestinal tract and the pancreas, which is involved in regulating glucose metabolism. Scope and approach: This review aims to demonstrate the link between gut and pancreas axis and establish the impact of dairy food products in T2DM via gut-pancreas axis. To achieve a comprehensive review on how dairy food products interact with T2DM, databases were screened and relevant papers were included in the content. Key finding and conclusions: Dairy products contain various components such as whey proteins, peptides and bioactive compounds that have been found to exert beneficial effects on glucose regulation. In research on the subject, it has been shown that consuming dairy products may improve insulin sensitivity, reduce insulin resistance and enhance pancreatic function, ultimately leading to better glycemic control in individuals with T2DM. Especially in studies conducted with probiotics or peptides isolated from dairy product, it has been observed that results that may be related to the gut-pancreas axis have been reached. In summary, dairy products contribute to the modulation of intestinal microbiota, improvement in intestinal permeability, increase in SCFAproducing bacteria, decrease in inflammatory and oxidative stress markers in tissues including liver and pancreas, especially in the intestine, and prevention of damage to pancreatic islets.
C1 [Agagunduz, Duygu] Gazi Univ, Fac Hlth Sci, Dept Nutr & Dietet, Ankara, Turkiye.
   [Yilmaz, Birsen] Cukurova Univ, Fac Hlth Sci, Dept Nutr & Dietet, Adana, Turkiye.
   [Yilmaz, Birsen] Tata Inst Fundamental Res, Dept Biol Sci, Hyderabad, India.
   [Cemali, Ozge] Trakya Univ, Fac Hlth Sci, Dept Nutr & Dietet, Edirne, Turkiye.
   [Simat, Vida] Univ Split, Dept Marine Studies, Split 21000, Croatia.
   [Akkus, Gamze] Cukurova Univ, Fac Med, Endocrinol Dept, Internal Med, Adana, Turkiye.
   [Kulawik, Piotr] Agr Univ Krakow, Fac Food Technol, Dept Anim Prod Proc, Ul Balicka 122, Krakow, Poland.
   [Ozogul, Fatih] Cukurova Univ, Fac Fisheries, Dept Seafood Proc Technol, Adana, Turkiye.
   [Ozogul, Fatih] Cukurova Univ, Biotechnol Res & Applicat Ctr, Adana, Turkiye.
C3 Gazi University; Cukurova University; Tata Institute of Fundamental
   Research (TIFR); Trakya University; University of Split; Cukurova
   University; University of Agriculture in Krakow; Cukurova University;
   Cukurova University
RP Yilmaz, B (corresponding author), Cukurova Univ, Fac Hlth Sci, Dept Nutr & Dietet, Adana, Turkiye.; Ozogul, F (corresponding author), Cukurova Univ, Fac Fisheries, Dept Seafood Proc Technol, Adana, Turkiye.
EM dytbirsen@gmail.com; fozogul@cu.edu.tr
RI Ağagündüz, Duygu/AAS-9583-2020; Šimat, Vida/A-4996-2010; OZOGUL,
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NR 174
TC 0
Z9 0
U1 16
U2 25
PU ELSEVIER SCIENCE LONDON
PI LONDON
PA 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND
SN 0924-2244
EI 1879-3053
J9 TRENDS FOOD SCI TECH
JI Trends Food Sci. Technol.
PD NOV
PY 2024
VL 153
AR 104741
DI 10.1016/j.tifs.2024.104741
EA OCT 2024
PG 17
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA J8P5A
UT WOS:001339626400001
DA 2025-06-11
ER

PT J
AU Mutakin
   Meiliana, A
   Wijaya, A
   Kobayashi, K
   Yamazaki, C
   Kameo, S
   Nakazawa, M
   Koyama, H
AF Mutakin
   Meiliana, Anna
   Wijaya, Andi
   Kobayashi, Kenji
   Yamazaki, Chiho
   Kameo, Satomi
   Nakazawa, Minato
   Koyama, Hiroshi
TI Association between selenium nutritional status and metabolic risk
   factors in men with visceral obesity
SO JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
LA English
DT Article
DE Selenium; Metabolic risk factors; Adipocytokines; Obesity; Metabolic
   syndrome
ID ACID-BINDING PROTEINS; SERUM SELENIUM; GLUTATHIONE-PEROXIDASE; OXIDATIVE
   STRESS; BLOOD SELENIUM; HEART-DISEASE; SUPPLEMENTATION; ANTIOXIDANTS;
   BIOMARKER
AB Background and aim: Previous evidence has suggested an association between selenium and cardiovascular disease, which is main outcome of metabolic syndrome. The aim of this study was to examine possible correlation between selenium nutritional status and metabolic risk factors in men with visceral obesity.
   Methods: Plasma samples were collected from 123 Indonesian men with visceral obesity. Their metabolic risk factors and selenium nutritional status were analyzed. The eligible subjects (n = 78) were stratified according to the International Diabetes Federation: obese, obese plus one component, and obese plus two components or more. Obese plus two components or more were diagnostic criteria of metabolic syndrome. Pearson's correlation was performed to examine the correlation in each group.
   Results: In the obese group, selenium positively correlated with high-density lipoprotein (HDL) cholesterol (r = 0.390, P < 0.05) and with fatty acid binding protein-4 (FABP4) (r = 0.474, P < 0.05); glutathione peroxidase-3 (GPx3) activity was inversely correlated with FABP4 (r = -467, P < 0.05). In the obese plus one component group, GPx3 activity positively correlated with HDL cholesterol (r = 0.413, P < 0.05). In the metabolic syndrome group, selenium negatively correlated with monocytes chemoattractant protein (MCP)-1 (r = -0.429, P < 0.05).
   Conclusions: These results show that the association between selenium nutritional status and metabolic risk factors is limited to particular group of obese men with or without metabolic syndrome. (C) 2012 Published by Elsevier GmbH.
C1 [Mutakin; Kobayashi, Kenji; Yamazaki, Chiho; Kameo, Satomi; Nakazawa, Minato; Koyama, Hiroshi] Gunma Univ, Dept Publ Hlth, Grad Sch Med, Maebashi, Gunma 3718511, Japan.
   [Mutakin] Padjadjaran State Univ, Fac Pharm, Jatinangor 45363, Indonesia.
   [Meiliana, Anna; Wijaya, Andi] Prodia Clin Lab, Jakarta 10430, Indonesia.
C3 Gunma University; Universitas Padjadjaran; Clinical Laboratory Prodia
RP Koyama, H (corresponding author), Gunma Univ, Dept Publ Hlth, Grad Sch Med, 3-39-22 Showa Machi, Maebashi, Gunma 3718511, Japan.
EM hkoyama@health.gunma-u.ac.jp
RI Meiliana, Anna/ABC-9368-2020; , Mutakin/AAB-8471-2021; Meiliana,
   Anna/IYS-6941-2023
OI Meiliana, Anna/0000-0002-4430-5952
CR Abdulah R, 2007, THROMB RES, V119, P305, DOI 10.1016/j.thromres.2006.02.005
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NR 41
TC 21
Z9 26
U1 0
U2 13
PU ELSEVIER GMBH
PI MUNICH
PA HACKERBRUCKE 6, 80335 MUNICH, GERMANY
SN 0946-672X
EI 1878-3252
J9 J TRACE ELEM MED BIO
JI J. Trace Elem. Med. Biol.
PY 2013
VL 27
IS 2
BP 112
EP 116
DI 10.1016/j.jtemb.2012.09.006
PG 5
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 135WN
UT WOS:000318321500007
PM 23199701
DA 2025-06-11
ER

PT J
AU da Silva, CA
   Ribeiro, JP
   Canto, JCAU
   da Silva, RE
   Silva, GB
   Botura, E
   Malschitzky, MAR
AF da Silva, Carlos Alberto
   Ribeiro, Jorge P.
   Canto, Julio Cesar A. U.
   da Silva, Ronaldo Ernani
   Silva Junior, Geraldo B.
   Botura, Edson
   Malschitzky, Marco Antonio R.
TI High-intensity aerobic training improves endothelium-dependent
   vasodilation in patients with metabolic syndrome and type 2 diabetes
   mellitus
SO DIABETES RESEARCH AND CLINICAL PRACTICE
LA English
DT Article
DE Endothelium vasodilation; Physical training; Ultrasound; Metabolic
   syndrome; Type 2 diabetes mellitus
ID REGULAR PHYSICAL-EXERCISE; FLOW-MEDIATED DILATION; NITRIC-OXIDE
   SYNTHASE; VASCULAR FUNCTION; CARDIOVASCULAR-DISEASE;
   FUNCTIONAL-CAPACITY; ARTERY; RISK; DYSFUNCTION; STRESS
AB Background: The aim of this study is to compare the effect of physical exercise program on the endothelial function of patients with metabolic syndrome and type 2 diabetes mellitus.
   Methods: Patients were randomized for high intensity aerobic training (HI: 80% maximum heart rate, n = 10), low intensity aerobic training (LI: 55% of maximum heart rate, n = 10) and control (n = 11). Before and after 6 weeks of training, subjects performed the maximal exercise test and a study of the endothelial function, through a high resolution ultrasound of the brachial artery, which was assessed after reactive hyperemia (endothelium dependent vasodilation) and nitrate administration (endothelium independent vasodilation).
   Results: A total of 31 patients with metabolic syndrome and type 2 diabetes mellitus were studied, with mean age of 58 +/- 6 years, The percentage diameter difference of the vessel after hyperemia was significantly higher for the high intensity group (HI before 2.52 +/- 2.85% and after 31.81 +/- 12.21%; LI before 3.23 +/- 3.52% and after 20.61 +/- 7.76%; controls before 3.56 +/- 2.33% and after 2.43 +/- 2.14%; p < 0.05).
   Conclusions: High intensity aerobic training improved the functional capability and endothelium dependent vasodilator response, but it does not improve the endothelium independent vasodilation in patients with metabolic syndrome and type 2 diabetes mellitus. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
C1 [da Silva, Carlos Alberto] Univ Fed Ceara, Inst Educ Fis & Esportes, BR-60455760 Fortaleza, Ceara, Brazil.
   [Ribeiro, Jorge P.] Univ Fed Rio Grande do Sul, Porto Alegre, RS, Brazil.
   [Canto, Julio Cesar A. U.; da Silva, Ronaldo Ernani] Cardiovita Clin, Blumenau, SC, Brazil.
   [Silva Junior, Geraldo B.] Univ Fed Ceara, Dept Internal Med, Sch Med, BR-60455760 Fortaleza, Ceara, Brazil.
   [Silva Junior, Geraldo B.] Univ Fortaleza, Sch Med, Hlth Sci Ctr, Fortaleza, Ceara, Brazil.
   [Botura, Edson] Uniangio Clin, Div Radiol, Blumenau, SC, Brazil.
   [Malschitzky, Marco Antonio R.] Santa Catarina Hosp, Div Biochem, Clin Anal Lab, Blumenau, SC, Brazil.
C3 Universidade Federal do Ceara; Universidade Federal do Rio Grande do
   Sul; Universidade Federal do Ceara; Universidade Fortaleza
RP da Silva, CA (corresponding author), Univ Fed Ceara, Inst Educ Fis & Esportes, Campus Pici,Bloco 320,Av Mister Hull,S SN, BR-60455760 Fortaleza, Ceara, Brazil.
EM carlosas@ymail.com; geraldobezerrajr@yahoo.com.br
RI Ribeiro, Jorge/B-5409-2010; Daher, Elizabeth/G-2210-2012; da Silva
   Júnior, Carlos Alberto/GXM-4655-2022; Silva Junior, Geraldo/U-5238-2017
OI Silva Junior, Geraldo/0000-0002-8971-0994
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U1 2
U2 26
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0168-8227
EI 1872-8227
J9 DIABETES RES CLIN PR
JI Diabetes Res. Clin. Pract.
PD FEB
PY 2012
VL 95
IS 2
BP 237
EP 245
DI 10.1016/j.diabres.2011.09.034
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 887TS
UT WOS:000299953900015
PM 22041126
DA 2025-06-11
ER

PT J
AU Hamdan, HZ
   Nasser, NM
   Adam, AM
   Saleem, MA
   Elamin, MI
AF Hamdan, Hamdan Z.
   Nasser, Nasser M.
   Adam, Ammar M.
   Saleem, Mahgoub A.
   Elamin, Maha I.
TI Serum Magnesium, Iron and Ferritin Levels in Patients with Diabetic
   Retinopathy Attending Makkah Eye Complex, Khartoum, Sudan
SO BIOLOGICAL TRACE ELEMENT RESEARCH
LA English
DT Article
DE Magnesium; Iron; Ferritin; Diabetes mellitus; Diabetic retinopathy;
   Sudan
ID INSULIN-RESISTANCE SYNDROME; OXIDATIVE STRESS; METABOLIC SYNDROME;
   MELLITUS; HYPOMAGNESEMIA; ASSOCIATION; DISEASE; RATS; PREVALENCE; WOMEN
AB Diabetic retinopathy is the most common complications of diabetes mellitus that, in most occasions, lead to blindness. Multiple evidences linked the serum magnesium, iron and ferritin disturbance with diabetes and its complications. A case-control study was conducted at Makkah Eye Complex, Khartoum, Sudan, to compare the levels of serum magnesium, iron and ferritin in patients with diabetic retinopathy with diabetic patients without diabetic retinopathy (controls). Findings indicate that all patients had type 2 diabetes. The two groups (50 in each arm) were well matched in their basic characteristics. Median (25th-75th interquartile) of serum magnesium in patients with diabetic retinopathy were significantly lower than patients without diabetic retinopathy [1.48 (0.75-1.64) vs. 1.92 (1.4-2.3)mg/dl, P = 0.022]. The median of serum iron and ferritin were lower in cases than control group but did not reach a statistical significance [20.5 (17.2-48.0) vs. 27.0 (16.0-54.0) mu g/dl, P = 0.568; 98.0 (45.0-134.75) vs. 101.0 (47.0-161.0) mu g/l, P = 0.818]. The duration of diabetes [16.5 (9.3) vs. 11.2 (6.6) years; P = 0.014] and haemoglobin level [13.7 (0.9) vs. 12.5 (2.0) g/dl; P = 0.039] were significantly higher in cases group than control group. A significant inverse correlation was observed between serum magnesium and iron levels. Twenty (40 %) patients had severe non-proliferative diabetic retinopathy with mild macular edema, which is the most prevalent type among the cases group. Hypomagnesaemia among diabetic patients was associated with diabetic retinopathy, while serum iron and ferritin have no significant effect in this setting. Severe non-proliferative diabetic retinopathy with mild macular edema is the prevalent type in this study.
C1 [Hamdan, Hamdan Z.; Adam, Ammar M.; Saleem, Mahgoub A.] Al Neelain Univ, Fac Med, Khartoum, Sudan.
   [Nasser, Nasser M.] Sudan Univ, Fac Med Lab, Khartoum, Sudan.
   [Elamin, Maha I.] Karary Univ, Fac Med, Omdurman, Sudan.
   [Hamdan, Hamdan Z.] Al Neelain Univ, Dept Biochem & Mol Biol, Fac Med, Khartoum, Sudan.
RP Hamdan, HZ (corresponding author), Al Neelain Univ, Dept Biochem & Mol Biol, Fac Med, POB 12702, Khartoum, Sudan.
EM hamdanology@hotmail.com
RI Fava, Natália/ABF-6325-2021; Hamdan, Hamdan Zaki/P-1290-2015
OI Hamdan, Hamdan Zaki/0000-0001-9269-8239
FU Zahybash for trading, Khartoum, Sudan
FX The study was funded by Zahybash for trading, Khartoum, Sudan.
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NR 43
TC 13
Z9 13
U1 0
U2 9
PU HUMANA PRESS INC
PI TOTOWA
PA 999 RIVERVIEW DRIVE SUITE 208, TOTOWA, NJ 07512 USA
SN 0163-4984
EI 1559-0720
J9 BIOL TRACE ELEM RES
JI Biol. Trace Elem. Res.
PD MAY
PY 2015
VL 165
IS 1
BP 30
EP 34
DI 10.1007/s12011-015-0236-4
PG 5
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA CF6DM
UT WOS:000352646900004
PM 25613583
DA 2025-06-11
ER

PT J
AU Correa, CR
   Chen, CYO
   Aldini, G
   Rasmussen, H
   Ronchi, CF
   Berchieri-Ronchi, C
   Cho, SM
   Blumberg, JB
   Yeum, KJ
AF Correa, Camila R.
   Chen, C-Y. Oliver
   Aldini, Giancarlo
   Rasmussen, Helen
   Ronchi, Carlos F.
   Berchieri-Ronchi, Carolina
   Cho, Soo-Muk
   Blumberg, Jeffrey B.
   Yeum, Kyung-Jin
TI Bioavailability of plant pigment phytochemicals in Angelica
   keiskei in older adults: A pilot absorption kinetic study
SO NUTRITION RESEARCH AND PRACTICE
LA English
DT Article
DE Angelica keiskei; quercetin; lutein; absorption kinetic; total
   antioxidant performance
ID METABOLIC SYNDROME; CHEMICAL-COMPONENTS; OXIDATIVE STRESS;
   BETA-CAROTENE; ANTIOXIDANT NUTRIENTS; DNA-DAMAGE; XANTHOANGELOL;
   CHALCONES; LUTEIN; SERUM
AB BACKGROUND/OBJECTIVES: Angelica keiskei is a green leafy vegetable rich in plant pigment phytochemicals such as flavonoids and carotenoids. This study examined bioavailability of flavonoids and carotenoids in Angelica keiskei and the alteration of the antioxidant performance in vivo.
   SUBJECTS AND MATERIALS: Absorption kinetics of phytochemicals in Angelica keiskei were determined in healthy older adults (>60 y, n = 5) and subjects with metabolic syndrome (n = 5). Subjects consumed 5 g dry Angelica keiskei powder encapsulated in gelatin capsules with a low flavonoid and carotenoid liquid meal. Plasma samples were collected at baseline, 0.5, 1, 2, 3, 4, 5, 6, 7, and 8 h. Samples were analyzed for flavonoids and carotenoids using HPLC systems with electrochemical and UV detection, respectively, and for total antioxidant performance by fluorometry.
   RESULTS: After ingestion of Angelica keiskei increases in plasma quercetin concentrations were observed at 1-3 and 6-8 hr in the healthy group and at all time points in the metabolic syndrome group compared to baseline (P < 0.05). Plasma lutein concentrations were significantly elevated in both the healthy and metabolic syndrome groups at 8 hr (P < 0.05). Significant increases in total antioxidant performance were also observed in both the healthy and the metabolic syndrome groups compared to baseline (P < 0.05).
   CONCLUSIONS: Findings of this study clearly demonstrate the bioavailability of phytonutrients of Angelica keiskei and their ability to increase antioxidant status in humans.
C1 [Correa, Camila R.; Chen, C-Y. Oliver; Rasmussen, Helen; Ronchi, Carlos F.; Berchieri-Ronchi, Carolina; Blumberg, Jeffrey B.] Tufts Univ, Jean Mayer USDA, Human Nutr Res Ctr Aging, Boston, MA 02111 USA.
   [Correa, Camila R.; Ronchi, Carlos F.; Berchieri-Ronchi, Carolina] Sao Paulo State Univ UNESP, Botucatu Med Sch, Dept Internal Med, BR-18618970 Botucatu, SP, Brazil.
   [Aldini, Giancarlo] Univ Milan, Dept Pharmaceut Sci, I-20133 Milan, Italy.
   [Cho, Soo-Muk] Natl Acad Agr Sci, Rural Dev Adm, Suwon 441853, South Korea.
   [Yeum, Kyung-Jin] Konkuk Univ, Coll Biomed & Hlth Sci, Chungju Si 380701, South Korea.
C3 Tufts University; United States Department of Agriculture (USDA);
   Universidade Estadual Paulista; University of Milan; Rural Development
   Administration (RDA), Republic of Korea; Konkuk University
RP Yeum, KJ (corresponding author), Konkuk Univ, Coll Biomed & Hlth Sci, Chungju Si 380701, South Korea.
EM kyeum@kku.ac.kr
RI Chen, Yung-Chung/GRY-3101-2022; Blumberg, Jeffrey/ABH-7888-2020; aldini,
   giancarlo/C-3533-2013; Correa, Camila/Q-2071-2019; Ronchi,
   Carlos/AAX-4811-2020
OI aldini, giancarlo/0000-0002-2355-6744; Yeum,
   Kyung-Jin/0000-0002-7846-0272; Ronchi, Carlos
   Fernando/0000-0002-5927-9320; Correa, Camila Renata/0000-0001-8493-5329
FU BioGreen 21 Program, Rural Development Administration, Korea
   [20070301034009]; U.S. Department of Agriculture [1950-51000-065-08S]
FX This research has been supported in part by the BioGreen 21 Program
   (Code #20070301034009), Rural Development Administration, Korea and U.S.
   Department of Agriculture, under agreement number 1950-51000-065-08S.
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NR 49
TC 10
Z9 11
U1 0
U2 15
PU KOREAN NUTRITION SOC
PI SEOUL
PA 804 KST CTR, 635-4 YEOGSAM-SONG KANGNAM-KU, SEOUL, 135-703, SOUTH KOREA
SN 1976-1457
EI 2005-6168
J9 NUTR RES PRACT
JI Nutr. Res. Pract.
PD OCT
PY 2014
VL 8
IS 5
BP 550
EP 557
DI 10.4162/nrp.2014.8.5.550
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA AQ1FG
UT WOS:000342526700011
PM 25324936
OA Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Giguère, Y
   Charland, M
   Thériault, S
   Bujold, E
   Laroche, M
   Rousseau, F
   Lafond, J
   Forest, JC
AF Giguere, Yves
   Charland, Marc
   Theriault, Sebastien
   Bujold, Emmanuel
   Laroche, Melissa
   Rousseau, Francois
   Lafond, Julie
   Forest, Jean-Claude
TI Linking preeclampsia and cardiovascular disease later in life
SO CLINICAL CHEMISTRY AND LABORATORY MEDICINE
LA English
DT Review
DE genetic determinants; long-term risk of cardiovascular disease;
   metabolic syndrome; preeclampsia
ID MATERNAL SUSCEPTIBILITY LOCUS; RENIN-ANGIOTENSIN SYSTEM;
   ISCHEMIC-HEART-DISEASE; GESTATIONAL HYPERTENSION; PRE-ECLAMPSIA;
   PREGNANCY COMPLICATIONS; GENETIC SUSCEPTIBILITY; MYOCARDIAL-INFARCTION;
   INFLAMMATORY MARKERS; METABOLIC SYNDROME
AB Preeclampsia (PE), which is defined as new onset hypertension after 20 weeks of pregnancy accompanied by proteinuria, is characterized by inadequate placentation, oxidative stress, inflammation and widespread endothelial dysfunction. A link between PE and long-term risk of cardiovascular disease (CVD) was suggested by retrospective studies, which found that PE was associated with a 2-3-fold risk of CVD later in life, with a 5-7-fold risk in the case of severe and/or early-onset PE. Recently, meta-analyses and prospective studies have confirmed the association between PE and the emergence of an unfavorable CVD risk profile, in particular a 3-5-fold increased prevalence of the metabolic syndrome only 8 years after the index pregnancy. PE and CVD share many risk factors, including obesity, hypertension, dyslipidemia, hypercoagulability, insulin resistance and both entities are characterized by endothelial dysfunction. PE and CVD are complex traits sharing common risk factors and pathophysiological processes, but the genetic link between both remains to be elucidated. However, recent evidence suggests that genetic determinants associated with the metabolic syndrome, inflammation and subsequent endothelial dysfunction are involved. As the evidence now supports that PE represents a risk factor for the emergence of the metabolic syndrome and CVD later in life, the importance of long-term follow-up assessment of CVD risk beginning early in women with a history of PE must be considered and translated into new preventive measures.
C1 [Giguere, Yves; Charland, Marc; Theriault, Sebastien; Bujold, Emmanuel; Laroche, Melissa; Rousseau, Francois; Forest, Jean-Claude] Univ Quebec, Ctr Hosp, Quebec City, PQ, Canada.
   [Giguere, Yves; Rousseau, Francois; Forest, Jean-Claude] Univ Laval, Fac Med, Dept Mol Biol Med Biochem & Pathol, Quebec City, PQ G1K 7P4, Canada.
   [Bujold, Emmanuel] Univ Laval, Fac Med, Dept Obstet & Gynecol, Quebec City, PQ G1K 7P4, Canada.
   [Lafond, Julie] Univ Quebec Montreal, Ctr Rech BioMed, Montreal, PQ, Canada.
   [Lafond, Julie] Univ Quebec Montreal, Dept Sci Biol, Montreal, PQ, Canada.
C3 University of Quebec; Laval University; Laval University; Laval
   University Hospital; Laval University; University of Quebec; University
   of Quebec Montreal; University of Quebec; University of Quebec Montreal
RP Giguère, Y (corresponding author), CRCHUQ, Hop St Francois Assise, 10 Rue Espinay, Quebec City, PQ G1L 3L5, Canada.
EM yves.giguere@crsfa.ulaval.ca
OI Bujold, Emmanuel/0000-0002-6936-4369; Theriault,
   Sebastien/0000-0003-1893-8307
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NR 101
TC 30
Z9 34
U1 0
U2 12
PU WALTER DE GRUYTER GMBH
PI BERLIN
PA GENTHINER STRASSE 13, D-10785 BERLIN, GERMANY
SN 1434-6621
EI 1437-4331
J9 CLIN CHEM LAB MED
JI Clin. Chem. Lab. Med.
PD JUN
PY 2012
VL 50
IS 6
BP 985
EP 993
DI 10.1515/CCLM.2011.764
PG 9
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA 963OO
UT WOS:000305631600003
PM 22107134
DA 2025-06-11
ER

PT B
AU James, WPT
   Rigby, N
   Leach, R
AF James, W. P. T.
   Rigby, N.
   Leach, R.
BE Chrousos, GP
   Tsigos, C
TI Obesity and the metabolic syndrome - The stress on society
SO STRESS, OBESITY, AND METABOLIC SYNDROME
SE Annals of the New York Academy of Sciences-Series
LA English
DT Article; Proceedings Paper
CT Bjorntorp Symposium on Stress, Obesity, and Metabolic Syndrome
CY APR 09-10, 2005
CL Athens, GREECE
SP Roche Hellas, Abbott Hellas, Pfizer Hellas, Sanofi Aventis Hellas, GlaxoSmithKline Hellas
DE obesity; health burden; ethnic differences; insulin resistance
ID PROVISIONAL REPORT; RISK-FACTORS; CLASSIFICATION; DEFINITION;
   PREVALENCE; MORTALITY
AB The problem of obesity was only accepted by the World Health Organization as of major public health importance in 1997 when the criteria for the specification of the metabolic syndrome were also being sought. Then the risk factor analyses of the determinants of global ill health at the start of the millennium showed that an excessive body mass index (BMI) above the optimum of 21 was one of the top 10 contributors. No analyses could be related to abdominal obesity because of the absence of systematic representative surveys of waist circumferences but the ill health attributable to excess weight included the risk factors specified in the metabolic syndrome and showed that the co-morbidities in Asia were far greater than those predicted from simply an excess weight. The recent proposed definition of the metabolic syndrome includes these different criteria specified on an ethnic basis but there is now a need to recognize that abdominal obesity is more common on the developing world and linked to childhood stunting and early deprivation. The importance of intrauterine and postnatal epigenetic and altered organ function needs to be recognized. Thus the co-morbidities associated with weight gain and the development of the metabolic syndrome dominate in the developing world where the majority of the population is proving more susceptible to the effects of weight gain than Caucasians now living in affluent societies. This therefore presents a major challenge in both research and public policy terms.
C1 Int Obes TaskForce, IASO, London NW1 2NS, England.
RP James, WPT (corresponding author), Int Obes TaskForce, IASO, 3rd Floor,231-3 N Gower St, London NW1 2NS, England.
EM JeanHJames@aol.com
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NR 31
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Z9 33
U1 0
U2 7
PU BLACKWELL SCIENCE PUBL
PI OXFORD
PA OSNEY MEAD, OXFORD OX2 0EL, ENGLAND
BN 978-1-57331-625-5
J9 ANN NY ACAD SCI
JI Ann.NY Acad.Sci.
PY 2006
VL 1083
BP 1
EP 10
DI 10.1196/annals.1367.002
PG 10
WC Endocrinology & Metabolism; Multidisciplinary Sciences
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Science & Technology - Other Topics
GA BFR90
UT WOS:000244102900002
PM 17148729
DA 2025-06-11
ER

PT J
AU Osman, A
   Benameur, T
   Korashy, HM
   Zeidan, A
   Agouni, A
AF Osman, Aisha
   Benameur, Tarek
   Korashy, Hesham M.
   Zeidan, Asad
   Agouni, Abdelali
TI Interplay between Endoplasmic Reticulum Stress and Large Extracellular
   Vesicles (Microparticles) in Endothelial Cell Dysfunction
SO BIOMEDICINES
LA English
DT Review
DE extracellular vesicles (EVs); microparticles (MPs); endoplasmic
   reticulum (ER) stress; endothelial dysfunction; cardiovascular disease;
   diabetes; metabolic syndrome
ID PLATELET-DERIVED MICROPARTICLE; UNFOLDED PROTEIN RESPONSE; NF-KAPPA-B;
   CIRCULATING MICROPARTICLES; NITRIC-OXIDE; OXIDATIVE STRESS; METABOLIC
   SYNDROME; PROGENITOR CELLS; DIABETIC-RATS; INHIBITION
AB Upon increased demand for protein synthesis, accumulation of misfolded and/or unfolded proteins within the endoplasmic reticulum (ER), a pro-survival response is activated termed unfolded protein response (UPR), aiming at restoring the proper function of the ER. Prolonged activation of the UPR leads, however, to ER stress, a cellular state that contributes to the pathogenesis of various chronic diseases including obesity and diabetes. ER stress response by itself can result in endothelial dysfunction, a hallmark of cardiovascular disease, through various cellular mechanisms including apoptosis, insulin resistance, inflammation and oxidative stress. Extracellular vesicles (EVs), particularly large EVs (lEVs) commonly referred to as microparticles (MPs), are membrane vesicles. They are considered as a fingerprint of their originating cells, carrying a variety of molecular components of their parent cells. lEVs are emerging as major contributors to endothelial cell dysfunction in various metabolic disease conditions. However, the mechanisms underpinning the role of lEVs in endothelial dysfunction are not fully elucidated. Recently, ER stress emerged as a bridging molecular link between lEVs and endothelial cell dysfunction. Therefore, in the current review, we summarized the roles of lEVs and ER stress in endothelial dysfunction and discussed the molecular crosstalk and relationship between ER stress and lEVs in endothelial dysfunction.
C1 [Osman, Aisha; Korashy, Hesham M.; Agouni, Abdelali] Qatar Univ, QU Hlth, Coll Pharm, Dept Pharmaceut Sci, Doha 2713, Qatar.
   [Benameur, Tarek] King Faisal Univ, Coll Med, Dept Biomed Sci, POB 400, Al Hasa 31982, Saudi Arabia.
   [Zeidan, Asad] Qatar Univ, QU Hlth, Dept Basic Med Sci, Doha 2713, Qatar.
C3 Qatar University; King Faisal University; Qatar University
RP Agouni, A (corresponding author), Qatar Univ, QU Hlth, Coll Pharm, Dept Pharmaceut Sci, Doha 2713, Qatar.
EM am1002749@student.qu.edu.qa; tbenameur@kfu.edu.sa; hkorashy@qu.edu.qa;
   a.zeidan@qu.edu.qa; aagouni@qu.edu.qa
RI Agouni, Abdelali/AAP-5298-2020; Korashy, Hesham/A-1059-2010; BENAMEUR,
   T/KIH-8629-2024
OI Agouni, Abdelali/0000-0002-8363-1582; Korashy, Hesham
   M./0000-0002-5745-9643
FU Qatar University [QUCG-CPH-20/21-3, QUST-2-CPH-2017-19,
   QUST-1-CPH-2018-1]; Qatar National Research Fund (a member of Qatar
   Foundation) [UREP24-016-3-004]
FX This research was funded by Qatar University grants (QUCG-CPH-20/21-3;
   QUST-2-CPH-2017-19; QUST-1-CPH-2018-1) and award UREP24-016-3-004 from
   Qatar National Research Fund (a member of Qatar Foundation). The
   statements made herein are solely the responsibility of the authors.
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NR 116
TC 15
Z9 17
U1 0
U2 4
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2227-9059
J9 BIOMEDICINES
JI Biomedicines
PD OCT
PY 2020
VL 8
IS 10
AR 409
DI 10.3390/biomedicines8100409
PG 23
WC Biochemistry & Molecular Biology; Medicine, Research & Experimental;
   Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Research & Experimental Medicine;
   Pharmacology & Pharmacy
GA OJ6UB
UT WOS:000584092600001
PM 33053883
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Meng, G
   Yang, H
   Bao, X
   Zhang, Q
   Liu, L
   Wu, H
   Du, H
   Xia, Y
   Shi, H
   Guo, X
   Liu, X
   Li, C
   Su, Q
   Gu, Y
   Fang, L
   Yu, F
   Sun, S
   Wang, X
   Zhou, M
   Jia, Q
   Guo, Q
   Song, K
   Huang, G
   Wang, G
   Wu, Y
   Niu, K
AF Meng, G.
   Yang, H.
   Bao, X.
   Zhang, Q.
   Liu, L.
   Wu, H.
   Du, H.
   Xia, Y.
   Shi, H.
   Guo, X.
   Liu, X.
   Li, C.
   Su, Q.
   Gu, Y.
   Fang, L.
   Yu, F.
   Sun, S.
   Wang, X.
   Zhou, M.
   Jia, Q.
   Guo, Q.
   Song, K.
   Huang, G.
   Wang, G.
   Wu, Y.
   Niu, K.
TI Increased serum ferritin levels are independently related to incidence
   of prediabetes in adult populations
SO DIABETES & METABOLISM
LA English
DT Article
DE Cohort study; Impaired fasting glucose; Insulin resistance; Prediabetes;
   Serum ferritin
ID BODY IRON STORES; INSULIN-RESISTANCE SYNDROME; DIABETES-MELLITUS;
   OXIDATIVE STRESS; METABOLIC SYNDROME; ASSOCIATION; COMPLICATIONS;
   GLUCOSE; WOMEN; RISK
AB Aim. - To comprehensively and exhaustively assess the relationship between serum ferritin levels and incidence of prediabetes in a prospective study.
   Methods. - This prospective cohort study (n = 7380) with a mean follow-up of 3.07 years (range: 1-7, 95% CI: 3.03-3.12) was conducted in Tianjin, China. Blood fasting glucose, oral glucose tolerance test, serum ferritin levels and other potentially confounding factors were measured at baseline and at each year of follow-up. Adjusted Cox proportional hazards regression models were used to assess the gender-specific relationship between baseline and mean serum ferritin quintiles and prediabetes.
   Results. - The incidence of prediabetes was 85 per 1000 person-years among men and 44 per 1000 person-years among women during follow-up (from 2007 to 2014). After adjusting for potential confounders, hazard ratios (95% CI) for prediabetes across baseline ferritin quintiles were: for men, 1.00, 1.13 (0.90-1.40), 1.20 (0.97-1.48), 1.41 (1.14-1.73) and 1.73 (1.41-2.11); and for women, 1.00, 1.01 (0.74-1.38), 0.68 (0.48-0.96), 0.84 (0.61-1.15) and 1.07 (0.80-1.45), respectively. Similar results were also observed for mean ferritin levels.
   Conclusion. - Both baseline and mean serum ferritin levels were significantly and linearly related to prediabetes in men, whereas U-shaped relationships were observed between baseline and mean serum ferritin and prediabetes in women. The relationship between prediabetes risk and mean serum ferritin levels may be more stable than one with baseline serum ferritin levels. (C) 2016 Published by Elsevier Masson SAS.
C1 [Meng, G.; Yang, H.; Bao, X.; Wu, H.; Du, H.; Xia, Y.; Guo, X.; Liu, X.; Li, C.; Su, Q.; Gu, Y.; Fang, L.; Yu, F.; Huang, G.; Wu, Y.; Niu, K.] Tianjin Med Univ, Nutr Epidemiol Inst, 22 Qixiangtai Rd, Tianjin 300070, Peoples R China.
   [Meng, G.; Yang, H.; Bao, X.; Wu, H.; Du, H.; Xia, Y.; Guo, X.; Liu, X.; Li, C.; Su, Q.; Gu, Y.; Fang, L.; Yu, F.; Huang, G.; Wu, Y.; Niu, K.] Tianjin Med Univ, Sch Publ Hlth, 22 Qixiangtai Rd, Tianjin 300070, Peoples R China.
   [Zhang, Q.; Liu, L.; Shi, H.; Sun, S.; Wang, X.; Zhou, M.; Jia, Q.; Song, K.; Wang, G.; Niu, K.] Tianjin Med Univ, Gen Hosp, Hlth Management Ctr, Tianjin, Peoples R China.
   [Guo, Q.] Tianjin Med Univ, Dept Rehabil & Sports Med, Tianjin, Peoples R China.
   [Huang, G.] Tianjin Med Univ, Collaborat Innovat Ctr Noncommunicable Dis, Tianjin, Peoples R China.
C3 Tianjin Medical University; Tianjin Medical University; Tianjin Medical
   University; Tianjin Medical University; Tianjin Medical University
RP Niu, K (corresponding author), Tianjin Med Univ, Nutr Epidemiol Inst, 22 Qixiangtai Rd, Tianjin 300070, Peoples R China.; Niu, K (corresponding author), Tianjin Med Univ, Sch Publ Hlth, 22 Qixiangtai Rd, Tianjin 300070, Peoples R China.
EM nkj0809@gmail.com
RI Niu, Kaijun/ADD-6222-2022; Xia, Yang/AAW-9116-2021
OI Niu, Kaijun/0000-0002-8772-2481; Xia, Yang/0000-0001-8783-1592; Bao,
   Xue/0000-0003-3777-5988
FU National Natural Science Foundation of China [81673166, 81372118,
   81372467, 81302422]; key technologies R&D program of Tianjin
   [11ZCGYSY05700, 12ZCZDSY20400, 13ZCZDSY20200, 15YFYZSY00020]; National
   Science and Technology Support Program [2012BAI02B02]; Chinese Nutrition
   Society (CNS) Nutrition Research Foundation - DSM Research Fund
   [2014-071, 2016-046]; Technologies development program of Beichen
   District of Tianjin [bcws2013-21, bcws2014-05]; technologies project of
   Tianjin Binhai New Area [2013-02-04, 2013-02-06]; Science Foundation of
   Tianjin Medical University [2010KY28, 2013KYQ24]; Key Laboratory of
   Public Health Safety (Fudan University), Ministry of Education
   [GW2014-5]; National Training Programs of Innovation and
   Entrepreneurship for Undergraduates, China [201510062013]
FX This study was supported by grants from the National Natural Science
   Foundation of China (No. 81673166, 81372118, 81372467 and 81302422), the
   key technologies R&D program of Tianjin (Key Project: No. 11ZCGYSY05700,
   12ZCZDSY20400, 13ZCZDSY20200, and 15YFYZSY00020), the National Science
   and Technology Support Program (No. 2012BAI02B02), 2012 and 2016 Chinese
   Nutrition Society (CNS) Nutrition Research Foundation - DSM Research
   Fund (No. 2014-071 and 2016-046), the Technologies development program
   of Beichen District of Tianjin (No. bcws2013-21 and bcws2014-05), the
   technologies project of Tianjin Binhai New Area (No. 2013-02-04 and
   2013-02-06), the Science Foundation of Tianjin Medical University (No.
   2010KY28 and 2013KYQ24), the Key Laboratory of Public Health Safety
   (Fudan University), Ministry of Education (No. GW2014-5), and the
   National Training Programs of Innovation and Entrepreneurship for
   Undergraduates (No. 201510062013), China.
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NR 40
TC 13
Z9 15
U1 0
U2 3
PU MASSON EDITEUR
PI MOULINEAUX CEDEX 9
PA 21 STREET CAMILLE DESMOULINS, ISSY, 92789 MOULINEAUX CEDEX 9, FRANCE
SN 1262-3636
EI 1878-1780
J9 DIABETES METAB
JI Diabetes Metab.
PD APR
PY 2017
VL 43
IS 2
BP 146
EP 153
DI 10.1016/j.diabet.2016.07.028
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA ET9MM
UT WOS:000400631600006
PM 27843075
OA Bronze
DA 2025-06-11
ER

PT J
AU Smith, M
   Cooper, A
   Hill, JO
   Yankovich, M
   Crofford, I
   Thomas, DM
AF Smith, Maria
   Cooper, Alma
   Hill, James O.
   Yankovich, Michael
   Crofford, Ira
   Thomas, Diana M.
TI Raising the US Army Height-Weight (Body Mass Index) Standards:
   Quantifying Metabolic Risk
SO MILITARY MEDICINE
LA English
DT Article
ID DISCRIMINATION; ASSOCIATION
AB Background & objectives The U.S. Army fell 25% short of its recruitment goal in 2022 and therefore, increasing the eligibility pool for potential recruits is of interest. Raising the body mass index (BMI) standards for eligibility presents a path to increase the recruitable population; however, there may be additional costs incurred due to attendant health risks that may be present in individuals with higher BMI.Methods We filtered the 2017-2020 National Health and Nutrition Examination Survey by age (17-25 years) and BMI (up to 30 kg/m2). A k-means cluster analysis was performed on the filtered dataset for the variables used to determine metabolic syndrome. Metabolic syndrome Clusters were characterized through summary statistics and compared over clinical measurements and questionnaire responses.Results Five distinct clusters were identified and mean BMI in two clusters (Clusters1 and 3) exceeded the current U.S. Army BMI thresholds. Of these two clusters, Cluster 1 members had metabolic syndrome. Cluster 3 members were at higher risk for metabolic syndrome compared to members of Clusters 2, 4, and 5. Mean waist circumference was slightly lower in Cluster 3 compared to Cluster 1. None of the clusters had significant differences in depression scores, poverty index, or frequency of dental visits.Conclusions Potential recruits from Cluster 1 have excessive health risk and may incur substantial cost to the U.S. Army if enlisted. However, potential recruits from Cluster 3 appear to add little risk and offer an opportunity to increase the pool for recruiting.
C1 [Smith, Maria; Cooper, Alma; Crofford, Ira; Thomas, Diana M.] United States Mil Acad, Dept Math Sci, West Point, NY 10996 USA.
   [Hill, James O.] Univ Alabama Birmingham, Dept Nutr Sci, Birmingham, AL 35294 USA.
   [Yankovich, Michael] Ramapo Coll, Operat Integrat Core, Mahwah, NJ 07430 USA.
C3 United States Department of Defense; United States Army; University of
   Alabama System; University of Alabama Birmingham; Ramapo College New
   Jersey (RCNJ)
RP Smith, M (corresponding author), United States Mil Acad, Dept Math Sci, West Point, NY 10996 USA.
RI Hill, Joseph/IRY-9183-2023
OI Thomas, Diana/0000-0003-2641-9304
FU National Institutes of Health (NIH) Inter Agency Agreement [AOD22022001]
FX D.M.T. was supported by National Institutes of Health (NIH) Inter Agency
   Agreement AOD22022001.
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NR 23
TC 0
Z9 0
U1 0
U2 3
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD MAY 18
PY 2024
VL 189
IS 5-6
BP e1174
EP e1180
DI 10.1093/milmed/usad450
EA NOV 2023
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA RP7G5
UT WOS:001107327200001
PM 37997687
OA hybrid
DA 2025-06-11
ER

PT J
AU Frisbee, JC
AF Frisbee, JC
TI Enhanced arteriolar α-adrenergic constriction impairs dilator responses
   and skeletal muscle perfusion in obese Zucker rats
SO JOURNAL OF APPLIED PHYSIOLOGY
LA English
DT Article
DE skeletal muscle blood flow regulation; skeletal muscle perfusion;
   regulation of vascular tone; models of metabolic syndrome X; obesity
ID CONTRACTION-INDUCED ATTENUATION; INSULIN-RESISTANCE; SYMPATHETIC
   VASOCONSTRICTION; OXIDANT STRESS; BLOOD-PRESSURE; SMOOTH-MUSCLE;
   SYNDROME-X; HYPERTENSION; ACTIVATION; FLOW
AB The present study tested the hypothesis that enhanced vascular alpha-adrenergic constriction in obese Zucker rats (OZR) impairs arteriolar dilation and perfusion of skeletal muscle at rest and with increased metabolic demand. In lean Zucker rats (LZR) and OZR, isolated gracilis arterioles were viewed via television microscopy, and the contralateral cremaster muscle or gastrocnemius muscle was prepared for study in situ. Gracilis and cremasteric arterioles were challenged with dilator stimuli under control conditions and after blockade of alpha-adrenoreceptors with prazosin, phentolamine, or yohimbine. Gastrocnemius muscles performed isometric twitch contractions of increasing frequency, and perfusion was continuously monitored. In OZR, dilator responses of arterioles to hypoxia (gracilis), wall shear rate (cremaster), acetylcholine, and iloprost (both) were impaired vs. LZR. Treatment with prazosin and phentolamine (and in cremasteric arterioles only, yohimbine) improved arteriolar reactivity to these stimuli in OZR, although responses remained impaired vs. LZR. Gastrocnemius muscle blood flow was reduced at rest in OZR; this was corrected with intravenous infusion of phentolamine or prazosin. At all contraction frequencies, blood flow was reduced in OZR vs. LZR; this was improved by infusion of phentolamine or prazosin at low-moderate metabolic demand only (1 and 3 Hz). At 5 Hz, adrenoreceptor blockade did not alter blood flow in OZR from levels in untreated rats. These results suggest that enhanced alpha-adrenergic constriction of arterioles of OZR contributes to impaired dilator responses and reduced muscle blood flow at rest and with mild-moderate (although not with large) elevations in metabolic demand.
C1 Med Coll Wisconsin, Dept Physiol, Milwaukee, WI 53226 USA.
C3 Medical College of Wisconsin
RP Med Coll Wisconsin, Dept Physiol, 8701 Watertown Plank Rd, Milwaukee, WI 53226 USA.
EM jfrisbee@mcw.edu
OI Frisbee, Jefferson/0000-0003-2751-0599
FU NHLBI NIH HHS [HL-29587, HL-65289] Funding Source: Medline
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NR 47
TC 50
Z9 60
U1 0
U2 0
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 8750-7587
EI 1522-1601
J9 J APPL PHYSIOL
JI J. Appl. Physiol.
PD AUG
PY 2004
VL 97
IS 2
BP 764
EP 772
DI 10.1152/japplphysiol.01216.2003
PG 9
WC Physiology; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology; Sport Sciences
GA 841NF
UT WOS:000222936500044
PM 15075303
DA 2025-06-11
ER

PT J
AU Yildirim, GY
   Tola, EN
   Dag, I
AF Yetkin Yildirim, Gonca
   Tola, Esra Nur
   Dag, Ismail
TI A novel biochemical marker-OKL38- with its apoptotic and
   antioxidant properties for the development of PCOS and its related
   clinical implications
SO GYNECOLOGICAL ENDOCRINOLOGY
LA English
DT Article
DE PCOS; OKL38; metabolic syndrome; cardiovascular disease risk
ID POLYCYSTIC-OVARY-SYNDROME; METABOLIC SYNDROME; OXIDATIVE STRESS; GROWTH
   INHIBITOR; GRANULOSA-CELLS; OKL38; ADOLESCENTS; PREVALENCE; INDUCTION;
   DIAGNOSIS
AB Aim: To investigate the role of serum OKL38 levels in the development of polycystic ovary syndrome (PCOS) and clinical implications related to PCOS. Method: PCOS (n = 33) and ovulatory controls (n = 48) were recruited for the study. Anthropometric measurements were recorded, and blood samples for hormonal and biochemical parameters including serum OKL38 levels were obtained. The potential role of OKL38 on the development of PCOS, metabolic syndrome and cardiovascular disease (CVD) were investigated. Framingham risk score (FRS) was used for the determination of CVD risk. Results: Mean Ferriman-Gallway (FG) score, insulin, low-density lipoprotein (LDL), total cholesterol (TC) levels, and the homeostasis model assessment of insulin resistance index (HOMA-IR) were significantly increased (p < .05) in women with PCOS compared to controls. PCOS group had lower mean OKL38 level compared to controls (p < .0001) and OKL38 was negatively predictive for the diagnosis of PCOS after adjustment of variables that were significantly different between two groups. A negative association between OKL38 and metabolic syndrome in PCOS women was evident after adjustment for age, obesity, and abdominal obesity. OKL38 level was also negatively correlated with body mass index, waist-to-hip-ratio, fat composition, serum TC, LDL, free testosterone levels, FRS, and FG scores. Conclusion: OKL38 may have a partial role in the etiopathogenesis of PCOS and may protect development of metabolic syndrome and CVD in women with PCOS.
C1 [Yetkin Yildirim, Gonca] Kanuni Sultan Suleyman Training & Res Hosp, Dept Obstet & Gynecol, Istanbul, Turkey.
   [Tola, Esra Nur] Istanbul Medipol Univ, Fac Med, Dept Obstet & Gynecol, Istanbul, Turkey.
   [Dag, Ismail] Eyup State Hosp, Dept Biochem, Istanbul, Turkey.
C3 Istanbul Kanuni Sultan Suleyman Training & Research Hospital; Istanbul
   Medipol University; Eyup State Hospital
RP Tola, EN (corresponding author), Istanbul Medipol Univ, Fac Med, Dept Obstet & Gynecol, Istanbul, Turkey.
EM perinatalog@hotmail.com
RI DAĞ, İsmail/AFM-3454-2022
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NR 25
TC 3
Z9 3
U1 0
U2 5
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0951-3590
EI 1473-0766
J9 GYNECOL ENDOCRINOL
JI Gynecol. Endocrinol.
PD AUG 2
PY 2020
VL 36
IS 8
BP 673
EP 677
DI 10.1080/09513590.2020.1718641
EA JAN 2020
PG 5
WC Endocrinology & Metabolism; Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Obstetrics & Gynecology
GA MT6SY
UT WOS:000511767900001
PM 31996062
DA 2025-06-11
ER

PT J
AU Yu, SS
   Yang, HM
   Guo, XF
   Zheng, LQ
   Sun, YX
AF Yu, Shasha
   Yang, Hongmei
   Guo, Xiaofan
   Zheng, Liqiang
   Sun, Yingxian
TI Metabolic syndrome and depressive symptoms among rural Northeast general
   population in China
SO BMC PUBLIC HEALTH
LA English
DT Article
ID MAJOR DEPRESSION; PROSPECTIVE COHORT; YOUNG-ADULTS; RISK-FACTORS;
   PREVALENCE; ASSOCIATIONS; ANXIETY; DISORDER; DISEASE; PEOPLE
AB Background: Previous researches aiming to estimate the association between metabolic syndrome and depressive symptoms come out with inconsistent results. Besides, most of them are conducted in the developed areas. There is lack of the data from rural China. The aim of this study is to confirm whether gender difference exists among the relationship between MetS, metabolic components and depressive symptoms in the rural Chinese population.
   Methods: A cross-sectional analysis enrolled 11430 subjects' aged >= 35 from rural Northeast China. Metabolic and anthropometric indicators were measured according to standard methods. Depressive symptoms were defined using the Patient Health Questionnaire-9 (PHQ-9).
   Results: The prevalence of depressive symptoms was 6% among rural Northeast general population and the prevalence of MetS and its components were 39.0% for MetS, 42.9% for abdominal obesity, 67.1% for elevated blood pressure, 47.1% for hyperglycemia, 32.1% for hypertriglyceridemia, 29.5% for low HDL-C. Depressive symptoms were associated with triglyceride component (OR = 1.24, 95% CI: 1.05-1.46, P = 0.01) but not MetS (OR = 1.11, 95% CI: 0.94-1.30, P = 0.23). Moreover, depressive symptoms were associated with triglyceride component (OR = 1.21, 95% CI = 1.00-1.47, P = 0.05) in women only. But once adjusted for menopause status, depressive symptoms were no longer statically associated with triglyceride component (OR = 1.20, 95% CI = 0.99-1.46, P = 0.07).
   Conclusions: Depressive symptoms were associated with triglyceride component but not MetS in rural Chinese population. Routine lipid screening should be recommended among rural depressed residents especially among female.
C1 [Yu, Shasha; Yang, Hongmei; Guo, Xiaofan; Sun, Yingxian] China Med Univ, Dept Cardiol, Hosp 1, Shenyang, Liaoning, Peoples R China.
   [Zheng, Liqiang] China Med Univ, Dept Clin Epidemiol, Shenjing Hosp, Shenyang, Liaoning, Peoples R China.
C3 China Medical University; China Medical University
RP Sun, YX (corresponding author), China Med Univ, Dept Cardiol, Hosp 1, Shenyang, Liaoning, Peoples R China.
EM sunyingxian12@aliyun.com
RI Sun, Yingxian/KHT-6171-2024
OI Sun, Yingxian/0000-0002-1961-899X
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NR 38
TC 19
Z9 21
U1 0
U2 7
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1471-2458
J9 BMC PUBLIC HEALTH
JI BMC Public Health
PD JAN 6
PY 2017
VL 17
AR 43
DI 10.1186/s12889-016-3913-0
PG 9
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA EJ0BT
UT WOS:000392874300014
PM 28061774
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Fumagalli, G
   Fabiani, F
   Forte, S
   Napolitano, M
   Marinelli, P
   Palange, P
   Pentassuglia, A
   Carlone, S
   Sanguinetti, CM
AF Fumagalli, Giorgio
   Fabiani, Fabrizio
   Forte, Silvia
   Napolitano, Massimiliano
   Marinelli, Paolo
   Palange, Paolo
   Pentassuglia, Antonella
   Carlone, Stefano
   Sanguinetti, Claudio Maria
TI INDACO project: a pilot study on incidence of comorbidities in COPD
   patients referred to pneumology units
SO MULTIDISCIPLINARY RESPIRATORY MEDICINE
LA English
DT Article
DE BMI; Charlson comorbidity index; Comorbidities; COPD; COPD exacerbation;
   FEV1; Inhaled drug therapy; Smoking
ID OBSTRUCTIVE PULMONARY-DISEASE; NUTRITION EXAMINATION SURVEY; C-REACTIVE
   PROTEIN; CARDIOVASCULAR-DISEASE; SYSTEMIC INFLAMMATION; METABOLIC
   SYNDROME; NATIONAL-HEALTH; LUNG-FUNCTION; MORTALITY; PREVALENCE
AB Background: Chronic Obstructive Pulmonary Disease (COPD) is often associated with comorbidities, especially cardiovascular, that have a heavy burden in terms of hospitalization and mortality. Since no conclusive data exist on the prevalence and type of comorbidities in COPD patients in Italy, we planned the INDACO observational pilot study to evaluate the impact of comorbidities in patients referred to the outpatient wards of four major hospitals in Rome.
   Methods: For each patient we recorded anthropometric and anamnestic data, smoking habits, respiratory function, GOLD (Global initiative for chronic Obstructive Lung Disease) severity stage, Body Mass Index (BMI), number of acute COPD exacerbations in previous years, presence and type of comorbidities, and the Charlson Comorbidity Index (CCI).
   Results: Here we report and discuss the results of the first 169 patients (124 males, mean age 74 +/- 8 years). The prevalence of patients with comorbidities was 94.1% (25.2% of cases presented only one comorbidity, 28.3% two, 46.5% three or more). There was a high prevalence of arterial hypertension (52.1%), metabolic syndrome (20.7%), cancers (13.6%) and diabetes (11.2%) in the whole study group, and of anxiety-depression syndrome in females (13%). Exacerbation frequency was positively correlated with dyspnea score and negatively with BMI. Use of combination of bronchodilators and inhaled corticosteroids was more frequent in younger patients with more severe airways obstruction and lower CCI.
   Conclusions: These preliminary results show a high prevalence of comorbidities in COPD patients attending four great hospitals in Rome, but they need to be confirmed by further investigations in a larger patients cohort.
C1 [Fumagalli, Giorgio] San Filippo Neri Gen Hosp, Dept Pulm, Rome, Italy.
   [Fabiani, Fabrizio; Forte, Silvia; Carlone, Stefano] San Giovanni Addolorata Gen Hosp, Dept Pulm, Rome, Italy.
   [Napolitano, Massimiliano; Pentassuglia, Antonella] San Giovanni Battista Hosp, Dept Pulm, Rome, Italy.
   [Marinelli, Paolo; Palange, Paolo] Univ Roma La Sapienza, Inst Internal Med, Dept Pulm, Rome, Italy.
   [Sanguinetti, Claudio Maria] Quisisana Clin Ctr, Rome, Italy.
   [Fumagalli, Giorgio] ACO San Filippo Neri, UOC Pneumol, I-00135 Rome, Italy.
C3 San Filippo Neri Hospital; Ospedale San Giovanni Battista Roma; Sapienza
   University Rome; San Filippo Neri Hospital
RP Fumagalli, G (corresponding author), San Filippo Neri Gen Hosp, Dept Pulm, Rome, Italy.
EM g.fumagalli@sanfilipponeri.roma.it
RI fumagalli, giorgio/AAH-6840-2019
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NR 42
TC 31
Z9 38
U1 0
U2 3
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 2049-6958
J9 MULTIDISCIP RESP MED
JI Multidscip. Respir. Med.
PD APR 3
PY 2013
VL 8
AR 28
DI 10.1186/2049-6958-8-28
PG 9
WC Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Respiratory System
GA 156DT
UT WOS:000319802000001
PM 23551874
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Gómez-Sámano, MA
   Grajales-Gómez, M
   Zuarth-Vázquez, JM
   Navarro-Flores, FM
   Martínez-Saavedra, M
   Juárez-León, OA
   Morales-García, MG
   Enríquez-Estrada, VM
   Gómez-Pérez, FJ
   Cuevas-Ramos, D
AF Angel Gomez-Samano, Miguel
   Grajales-Gomez, Mariana
   Maria Zuarth-Vazquez, Julia
   Fernanda Navarro-Flores, Ma
   Martinez-Saavedra, Mayela
   Alfredo Juarez-Leon, Oscar
   Morales-Garcia, Mariana G.
   Manuel Enriquez-Estrada, Victor
   Gomez-Perez, Francisco J.
   Cuevas-Ramos, Daniel
TI Fibroblast growth factor 21 and its novel association with oxidative
   stress
SO REDOX BIOLOGY
LA English
DT Article
DE FGF21; Oxidative stress; Insulin resistance; Metabolic syndrome;
   Diabetes
ID ENDOPLASMIC-RETICULUM STRESS; UNFOLDED PROTEIN RESPONSE; SERUM FGF21
   LEVELS; HIGH-FAT DIET; HEPATIC GLUCONEOGENESIS; INSULIN-RESISTANCE;
   LIPID-METABOLISM; NRF2; GLUCOSE; OBESITY
AB Fibroblast growth factor 21 (FGF21) is an endocrine-member of the FGF family. It is synthesized mainly in the liver, but it is also expressed in adipose tissue, skeletal muscle, and many other organs. It has a key role in glucose and lipid metabolism, as well as in energy balance. FGF21 concentration in plasma is increased in patients with obesity, insulin resistance, and metabolic syndrome. Recent findings suggest that such increment protects tissue from an increased oxidative stress environment. Different types of physical stress, such as strenuous exercising, lactation, diabetic nephropathy, cardiovascular disease, and critical illnesses, also increase FGF21 circulating concentration. FGF21 is now considered a stress-responsive hormone in humans. The discovery of an essential response element in the FGF21 gene, for the activating transcription factor 4 (ATF4), involved in the regulation of oxidative stress, and its relation with genes such as NRF2, TBP-2, UCP3, SOD2, ERK, and p38, places FGF21 as a key regulator of the oxidative stress cell response. Its role in chronic diseases and its involvement in the treatment and follow-up of these diseases has been recently the target of new studies. The diminished oxidative stress through FGF21 pathways observed with anti-diabetic therapy is another clue of the new insights of this hormone.
C1 [Angel Gomez-Samano, Miguel; Grajales-Gomez, Mariana; Maria Zuarth-Vazquez, Julia; Fernanda Navarro-Flores, Ma; Martinez-Saavedra, Mayela; Alfredo Juarez-Leon, Oscar; Morales-Garcia, Mariana G.; Manuel Enriquez-Estrada, Victor; Gomez-Perez, Francisco J.; Cuevas-Ramos, Daniel] Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Endocrinol & Metab, Vasco de Quiroga 15,Secc 16, Mexico City 14000, DF, Mexico.
C3 Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran -
   Mexico
RP Cuevas-Ramos, D (corresponding author), Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Endocrinol & Metab, Vasco de Quiroga 15,Secc 16, Mexico City 14000, DF, Mexico.
EM miguelangelgomezsamano@gmail.com; marianagrago@gmail.com;
   juliazuarth@gmail.com; fer.navarroflores@gmail.com;
   mayela.saa@gmail.com; oajl09@gmail.com;
   marianaguadalupe.morales@upaep.edu.mx; vicmanuel280@gmail.com;
   gomezperezfco@gmail.com; ceptamim@gmail.com
OI enriquez estrada, victor manuel/0000-0001-9002-5276
FU Department of Endocrinology and Metabolism
FX This research was funded by the Department of Endocrinology and
   Metabolism. Instituto Nacional de Ciencias Medicas y Nutricion Salvador
   Zubiran. Vasco de Quiroga # 15, Seccion XVI Tlalpan 14000, Mexico City,
   Mexico.
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NR 96
TC 116
Z9 128
U1 2
U2 36
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2213-2317
J9 REDOX BIOL
JI Redox Biol.
PD APR
PY 2017
VL 11
BP 335
EP 341
DI 10.1016/j.redox.2016.12.024
PG 7
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA EQ6RY
UT WOS:000398212000034
PM 28039838
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Semenkovich, CF
AF Semenkovich, Clay F.
TI Insulin resistance and atherosclerosis
SO JOURNAL OF CLINICAL INVESTIGATION
LA English
DT Review
ID CORONARY-HEART-DISEASE; ENDOPLASMIC-RETICULUM STRESS;
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   CARDIOVASCULAR-DISEASE; MOUSE MODEL; SECONDARY PREVENTION; DNA-DAMAGE
AB Considerable evidence supports the association between insulin resistance and vascular disease, and this has led to wide acceptance of the clustering of hyperlipidemia, glucose intolerance, hypertension, and obesity as a clinical entity, the metabolic syndrome. While insulin resistance, by promoting dyslipidemia and other metabolic abnormalities, is part of the proatherogenic milieu, it is possible that insulin resistance itself in the vascular wall does not promote atherosclerosis. Recent findings suggest that insulin resistance and atherosclerosis could represent independent and ultimately maladaptive responses to the disruption of cellular homeostasis caused by the excess delivery of fuel.
C1 Washington Univ, Sch Med, Div Endocrinol Metab & Lipid Res, St Louis, MO 63110 USA.
C3 Washington University (WUSTL)
RP Semenkovich, CF (corresponding author), Washington Univ, Sch Med, Div Endocrinol Metab & Lipid Res, St Louis, MO 63110 USA.
EM csemenko@wustl.edu
RI Segura-Aguilar, Juan/H-8839-2013
OI Semenkovich, Clay/0000-0003-1163-1871
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NR 125
TC 329
Z9 359
U1 0
U2 13
PU AMER SOC CLINICAL INVESTIGATION INC
PI ANN ARBOR
PA 2015 MANCHESTER RD, ANN ARBOR, MI 48104 USA
SN 0021-9738
EI 1558-8238
J9 J CLIN INVEST
JI J. Clin. Invest.
PD JUL
PY 2006
VL 116
IS 7
BP 1813
EP 1822
DI 10.1172/JCI29024
PG 10
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 062DN
UT WOS:000238924900010
PM 16823479
OA Green Published, Green Submitted, Bronze
DA 2025-06-11
ER

PT J
AU Machado, M
   Cortez-Pinto, H
AF Machado, M
   Cortez-Pinto, H
TI Non-alcoholic fatty liver disease and insulin resistance
SO EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
LA English
DT Article
DE non-alcoholic fatty liver disease; non-alcoholic steatohepatitis;
   insulin resistance; metabolic syndrome; obesity
ID METABOLIC SYNDROME; NATURAL-HISTORY; STEATOHEPATITIS; OBESITY; DIET;
   DEFINITION; EXPRESSION; METFORMIN; MODEL; NASH
AB Non-alcoholic fatty liver disease (NAFLD) is an entity now recognized as one of the leading causes of asymptomatic chronic elevation of aminotransferase levels, which can, however, progress to more advanced forms of hepatic lesion and ultimately to liver failure. Insulin resistance is considered as having a central role in NAFLD pathogenesis, which is related with oxidative stress, abnormal production of cytokines and deregulation of fatty acid metabolism. In this article the authors make a brief review of the epidemiological data about NAFLD and insulin resistance, and their aetiological link, and treatment implications.
C1 Univ Hosp Santa Maria, Dept Gastroenterol, Ctr Nutr & Metab, Lisbon, Portugal.
C3 Universidade de Lisboa; Hospital Santa Maria
RP Hosp Santa Maria, Ctr Gastroenterol, Av Prof Egas Moniz, P-1649035 Lisbon, Portugal.
EM hlcortezpinto@netcabo.pt
RI Cortez-Pinto, Helena/AAN-2712-2020
OI Cortez-Pinto, Helena/0000-0002-8537-8744
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NR 41
TC 49
Z9 57
U1 1
U2 7
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0954-691X
EI 1473-5687
J9 EUR J GASTROEN HEPAT
JI Eur. J. Gastroenterol. Hepatol.
PD AUG
PY 2005
VL 17
IS 8
BP 823
EP 826
DI 10.1097/00042737-200508000-00008
PG 4
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 957RX
UT WOS:000231392100008
PM 16003131
OA Bronze
DA 2025-06-11
ER

PT J
AU Kuehl, LK
   Hinkelmann, K
   Muhtz, C
   Dettenborn, L
   Wingenfeld, K
   Spitzer, C
   Kirschbaum, C
   Wiedemann, K
   Otte, C
AF Kuehl, Linn K.
   Hinkelmann, Kim
   Muhtz, Christoph
   Dettenborn, Lucia
   Wingenfeld, Katja
   Spitzer, Carsten
   Kirschbaum, Clemens
   Wiedemann, Klaus
   Otte, Christian
TI Hair cortisol and cortisol awakening response are associated with
   criteria of the metabolic syndrome in opposite directions
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE Hair cortisol; Hair cortisone; Cortisol awakening response; Metabolic
   syndrome
ID SCALP HAIR; LOCALIZATION; BIOMARKER
AB Findings on the association between hypothalamic pituitary adrenal (HPA) axis activity and metabolic risk are equivocal. Different methods of measuring HPA activity might indicate adverse vs. beneficial effects of HPA activity on metabolic risk thus contributing to heterogenous findings. In this study, we aimed to determine whether (1) the salivary cortisol awakening response (CAR) as a marker of awakening-induced activation of the HPA axis and (2) hair cortisol as a marker of long-term cortisol secretion are associated with criteria of the metabolic syndrome. Therefore, we recruited 41 healthy individuals (26 women, mean age: 41.2 years) and 44 patients with major depression (28 women, 41.4 years) and assessed CAR and hair cortisol values as well as all criteria of the metabolic syndrome (abdominal obesity, blood pressure, plasma glucose, triglycerides and high-density cholesterol levels) according to the International Diabetes Federation. CAR and hair cortisol values were divided into tertiles. Across groups, participants with hair cortisol or hair cortisone in the highest tertile showed significantly more criteria of the metabolic syndrome compared to participants in the medium or low tertile (F-2,F-64 = 3.37, p = .04). These results were corroborated by significant positive correlations between mean hair cortisol values with waist circumference (r = .29, p = .03), triglycerides (r = .34, p = .01) and systolic blood pressure (r = .29, p = .04) and between mean hair cortisone and triglycerides (r = .46, p < .01). In contrast, mean CAR values correlated negatively with diastolic (r = -.29, p = .03) and systolic blood pressure (r = -.32, p = .02). Our results indicate that higher hair cortisol and hair cortisone levels but lower CAR values are associated with an unfavorable metabolic and cardiovascular risk profile. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Kuehl, Linn K.; Hinkelmann, Kim; Wingenfeld, Katja; Otte, Christian] Charite Univ Med Sch Berlin, Dept Psychiat & Psychotherapy, D-14050 Berlin, Germany.
   [Muhtz, Christoph] Univ Med Ctr Hamburg Eppendorf, Dept Psychosomat Med, Hamburg, Germany.
   [Dettenborn, Lucia] Univ Med Ctr Hamburg Eppendorf, Dept Med Psychol, Hamburg, Germany.
   [Spitzer, Carsten] Asklepios Fachklinikum Tiefenbrunn, Rosdorf, Germany.
   [Kirschbaum, Clemens] Tech Univ Dresden, Dept Psychol, D-01062 Dresden, Germany.
   [Wiedemann, Klaus] Univ Med Ctr Hamburg Eppendorf, Dept Psychiat, Hamburg, Germany.
C3 Berlin Institute of Health; Free University of Berlin; Humboldt
   University of Berlin; Charite Universitatsmedizin Berlin; University of
   Hamburg; University Medical Center Hamburg-Eppendorf; University of
   Hamburg; University Medical Center Hamburg-Eppendorf; Technische
   Universitat Dresden; University of Hamburg; University Medical Center
   Hamburg-Eppendorf
RP Kuehl, LK (corresponding author), Charite Univ Med Sch Berlin, Dept Psychiat & Psychotherapy, Campus Benjamin Franklin,Eschenallee 3, D-14050 Berlin, Germany.
EM linn.kuehl@charite.de
RI Kirschbaum, Clemens/AAB-1752-2020
OI Wingenfeld, Katja/0000-0001-7457-0370; Kuehl, Linn/0000-0001-6871-6302;
   Otte, Christian/0000-0002-4051-997X
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NR 22
TC 72
Z9 77
U1 1
U2 23
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD JAN
PY 2015
VL 51
BP 365
EP 370
DI 10.1016/j.psyneuen.2014.09.012
PG 6
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA AY5BI
UT WOS:000347588000033
PM 25462908
DA 2025-06-11
ER

PT J
AU Zhang, Z
   Zhang, WL
   Li, J
   Xiao, MJ
AF Zhang, Zheng
   Zhang, Wan-Li
   Li, Jia
   Xiao, Mei-Juan
TI Metabolic Syndrome is Associated with White Matter Hyperintensity in
   Stroke Patients
SO BRAIN IMPAIRMENT
LA English
DT Article
DE Leukoaraiosis; WMH; MetS; MRI
ID POSTSTROKE DEPRESSION; BARTHEL INDEX; HOSPITAL ANXIETY; POST STROKE;
   SYMPTOMS; OUTCOMES; PREVALENCE; REHABILITATION; EPIDEMIOLOGY; PREDICTORS
AB Some risk factors of stroke may play a role in white matter hyperintensity (WMH). Metabolic syndrome (MetS) is a recognised risk factor of stroke, but it is controversial whether MetS is also associated with WMH. We examined the association of MetS with the prevalence of WMH in acute stroke patients. We conducted a cross-sectional study in 246 acute ischemia stroke patients. The patients with acute stroke were clinically evaluated, including waistline circumference, blood pressure, glycaemia, serum triglyceride and high density lipoprotein cholesterol level. The degree of WMH was assessed by Fluid-attenuated inversion recovery (FLAIR) sequence of magnetic resonance imaging (MRI) scans. MetS was diagnosed using the criteria by the National Cholesterol Education Adult Treatment Panel III. MetS was the independent variable evaluated in Binary regression analyses. It is found that old age (>60 years old), MetS and smoking were significantly associated with WMH in univariate analysis (p < .05). Spearman rank correlation showed that old age and MetS are related to WMH (r = 0.18, p = .005 and r = 0.18, p = .004, respectively). Hypertension is weakly but not significantly associated with WMH in correlation analysis (r = 0.11, p = .08). In multiple regression analysis, age and MetS remained independently associated with WMH (OR = 7.6, 95% CI 0.2-0.7 and OR = 11.7, 95% CI 0.1-0.5). Hypertension and hyperglycaemia tend to be associated but not significantly with WMH (p = .07, p = .08). Other MetS components such as large waist circumference and dyslipidaemia showed no association with WMH. After adjustment for age, WMH is significantly associated with MetS in stroke patients. Hypertension and hyperglycaemia tend to associated but not significantly with WMH in stroke patients.
C1 [Zhang, Zheng; Zhang, Wan-Li; Li, Jia; Xiao, Mei-Juan] Wenzhou Med Univ, Affiliated Hosp 1, Dept Neurol, Wenzhou 325000, Zhejiang, Peoples R China.
C3 Wenzhou Medical University
RP Xiao, MJ (corresponding author), Wenzhou Med Univ, Affiliated Hosp 1, Dept Neurol, Wenzhou 325000, Zhejiang, Peoples R China.
EM cnzzdoc@126.com
RI li, jiani/HNJ-1498-2023
FU Wenzhou Science and Technology Bureau [Y20120154]
FX This study was supported by Wenzhou Science and Technology Bureau
   (Y20120154).
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NR 39
TC 0
Z9 0
U1 0
U2 4
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
SN 1443-9646
EI 1839-5252
J9 BRAIN IMPAIR
JI Brain Impair.
PD DEC
PY 2017
VL 18
IS 3
BP 277
EP 283
DI 10.1017/BrImp.2017.9
PG 7
WC Clinical Neurology; Neurosciences; Rehabilitation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Rehabilitation
GA FS0YI
UT WOS:000419499900005
DA 2025-06-11
ER

PT J
AU Lucini, D
   Malacarne, M
   Gatzemeier, W
   Pagani, E
   Bernardelli, G
   Parati, G
   Pagani, M
AF Lucini, Daniela
   Malacarne, Mara
   Gatzemeier, Wolfgang
   Pagani, Eleonora
   Bernardelli, Giuseppina
   Parati, Gianfranco
   Pagani, Massimo
TI Evidence of Better Autonomic, Metabolic and Psychological Profile in
   Breast Cancer Survivors Meeting Current Physical Activity
   Recommendations: An Observational Study
SO JOURNAL OF PERSONALIZED MEDICINE
LA English
DT Article
DE autonomic nervous system; prevention; exercise; nutrition; heart rate
   variability
ID HEART-RATE-VARIABILITY; CARDIORESPIRATORY FITNESS;
   CARDIOVASCULAR-DISEASE; ACTIVITY QUESTIONNAIRE; SCIENTIFIC STATEMENT;
   NERVOUS-SYSTEM; EXERCISE; RISK; HEALTH; ASSOCIATIONS
AB The increased cardiometabolic risk observed in breast cancer survivors (BCS) is due to multiple mechanisms: Hormonal and immunological dysfunction are well-identified ones, while cardiac autonomic regulation (CAR) is less recognized but may play a new complementary role particularly relevant when considering conditions and behaviors associated with a better prognosis in BCS, such as physical training. This observational study investigated a group of consecutive (172) BCS subdivided in two groups: those who reached the physical activity goals above 600 (MET center dot min/week) and those who did not. We assessed CAR by autoregressive spectral analysis of cardiovascular variabilities (considering in particular the unitary autonomic nervous system index-ANSI), body mass composition, stress perception and lifestyle in order to verify possible differences due to execution of physical activity. Subjects who spontaneously met physical activity recommendations presented a better autonomic, metabolic and psychological profile compared to those who did not. Lower physical activity volume, poor metabolic parameters, increased stress and fatigue perception may cluster together, leading to worsened CAR. This control mechanism may play a complementary role in determining the increased cardiometabolic risk observed in BCS. Furthermore, it may also explain, albeit in part, the better prognosis observed in patients following interventions aiming to improve the sympathetic-parasympathetic balance, such as physical training, using a personalized medicine approach.
C1 [Lucini, Daniela; Malacarne, Mara] Univ Milan, BIOMETRA Dept, I-20129 Milan, Italy.
   [Lucini, Daniela; Malacarne, Mara; Pagani, Massimo] Ist Auxol Italiano, IRCCS, Exercise Med Unit, I-20135 Milan, Italy.
   [Gatzemeier, Wolfgang] Humanitas Clin & Res Ctr, Canc Ctr, I-20089 Rozzano, Italy.
   [Pagani, Eleonora] Catholic Univ Sacred Hearth, Dept Psychol, I-20123 Milan, Italy.
   [Bernardelli, Giuseppina] Univ Milan, DISCCO Dept, I-20122 Milan, Italy.
   [Parati, Gianfranco] Univ Milano Bicocca, Dept Med & Surg, I-20126 Milan, Italy.
   [Parati, Gianfranco] Ist Auxol Italiano, IRCCS, Dept Cardiol, I-20145 Milan, Italy.
C3 University of Milan; IRCCS Istituto Auxologico Italiano; IRCCS Humanitas
   Research Hospital; Catholic University of the Sacred Heart; University
   of Milan; University of Milano-Bicocca; IRCCS Istituto Auxologico
   Italiano
RP Lucini, D (corresponding author), Univ Milan, BIOMETRA Dept, I-20129 Milan, Italy.; Lucini, D (corresponding author), Ist Auxol Italiano, IRCCS, Exercise Med Unit, I-20135 Milan, Italy.
EM daniela.lucini@unimi.it; mara.malacarne@unimi.it;
   wolfgang.gatzemeier@humanitas.it; eleonora.pagani@unicatt.it;
   g.bernardelli@unimi.it; gianfranco.parati@unimib.it;
   massimo.paganiz@gmail.com
RI Bernardelli, Giuseppina/GWC-6381-2022; Parati, Gianfranco/K-7151-2016;
   Gatzemeier, Wolfgang/HMV-2117-2023; Lucini, Daniela/ABD-7517-2021
OI Parati, Gianfranco/0000-0001-9402-7439; Gatzemeier,
   Wolfgang/0000-0002-4026-0283; Lucini, Daniela/0000-0003-4845-8988
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NR 50
TC 2
Z9 2
U1 0
U2 8
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2075-4426
J9 J PERS MED
JI J. Pers. Med.
PD FEB
PY 2022
VL 12
IS 2
AR 273
DI 10.3390/jpm12020273
PG 12
WC Health Care Sciences & Services; Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services; General & Internal Medicine
GA ZK1ZQ
UT WOS:000762794400001
PM 35207761
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Correa-Burrows, P
   Burrows, R
   Albala, C
   Court, FA
   Salech, F
   Sanhueza, G
   Gonzalez-Billault, C
AF Correa-Burrows, P.
   Burrows, R.
   Albala, C.
   Court, F. A.
   Salech, F.
   Sanhueza, G.
   Gonzalez-Billault, C.
TI Multiple events case-control study in a prospective cohort to identify
   systemic, cellular, and molecular biomarkers of obesity-induced
   accelerated aging in 30-years-olds: the ObAGE study protocol
SO BMC GERIATRICS
LA English
DT Article
DE Obesity; Aging; Epigentic age; Resilience; Early-onset cardiometabolic
   risk; Sarcopenia; Dysbiosis
ID KOREA NATIONAL-HEALTH; LOW MUSCLE MASS; METABOLIC SYNDROME;
   CARDIOMETABOLIC OUTCOMES; CHILDHOOD ADVERSITY; SENSITIVE PERIODS;
   YOUNG-ADULTS; LIFE-SPAN; STRESS; CHALLENGES
AB Background Aging is characterized by a progressive loss of capacities linked to fundamental alterations/damage in multiple cellular and molecular pathways. It is the most significant risk factor for all non-communicable diseases (NCDs). Another contributing factor to the rise in NCDs is obesity. It has been suggested that obesity not only accelerates the onset of metabolic imbalances but also decreases lifespan and impacts cellular and molecular processes in a manner similar to aging. Obesity might accelerate the pace of aging. Guided by a lifecourse approach, we will explore how exposure to obesity in critical developmental stages disrupt homeostatic resilience mechanisms that preserve physiological integrity, inducing an early expression of aging phenotypes. Also, we will determine whether exposure to early psychosocial adversity influences vulnerability to obesity as a risk factor for accelerated aging. Methods Multiple events case-control study embedded in a prospective cohort of Chileans at 30-31y, 50% females, of low- to-middle socioeconomic status, who participated in nutrition research since birth. At 23y, 25% had obesity and cardiometabolic risk was high. We will use a multi-layer approach including: anthropometric assessment; DXA scan for body composition; abdominal ultrasound of the liver; stool samples collection and sequencing of the ribosomal RNA 16S gene to characterize the gut microbiome; determination of age-related pro-inflammatory cytokynes and anti-inflammatory miokynes. For the first time in Chile, we will address age-related epigenetic changes using the Horvath ' s epigenetic clock. In a subset we will conduct a controlled physical challenge to characterize physical resilience (autophagy). Discussion ObAGE is in an excellent position to: approach aging as a process whose expression involves multiple factors from the early stages of a person's life; understand how longitudinal changes in health trajectories impact the biological mechanisms of aging; identify potential resilience mechanisms that help prevent unhealthy aging. Because SLS participants are still young, our research setting combined with advanced scientific techniques may identify individuals or groups at risk of early onset health issues. Results from ObAGE may pave the way to address the contribution of obesity to aging through lifespan from cells to systems and might be instrumental to developing interventions to improve health span in the Chilean population.
C1 [Correa-Burrows, P.; Burrows, R.; Albala, C.; Gonzalez-Billault, C.] Univ Chile, Inst Nutr & Food Technol, Santiago, Chile.
   [Court, F. A.] Univ Mayor, Ctr Integrat Biol, Santiago, Chile.
   [Court, F. A.; Salech, F.; Gonzalez-Billault, C.] Gerosci Ctr Brain Hlth & Metab GERO, Santiago, Chile.
   [Court, F. A.; Gonzalez-Billault, C.] Buck Inst Aging Res, Novato, CA USA.
   [Salech, F.; Gonzalez-Billault, C.] Univ Chile, Fac Med, Santiago, Chile.
   [Sanhueza, G.] Univ Chile, Fac Social Sci, Santiago, Chile.
   [Gonzalez-Billault, C.] Univ Chile, Fac Sci, Santiago, Chile.
C3 Universidad de Chile; Universidad Mayor; Buck Institute for Research on
   Aging; Universidad de Chile; Universidad de Chile; Universidad de Chile
RP Correa-Burrows, P (corresponding author), Univ Chile, Inst Nutr & Food Technol, Santiago, Chile.
EM paulina.correa@inta.uchile.cl
RI Court, Felipe/C-5911-2015; Gonzalez-Billault, Christian/P-2393-2019;
   Burrows, Raquel/A-8489-2015; Correa-Burrows, Paulina/O-7436-2014;
   Gonzalez-Billault, Christian/K-9622-2013
OI Sanhueza, Guillermo/0000-0003-1971-7362; Correa-Burrows,
   Paulina/0000-0002-6177-1162; Court, Felipe/0000-0002-9394-7601; Salech,
   Felipe/0000-0003-1575-7658; Gonzalez-Billault,
   Christian/0000-0003-0335-1482
FU Agencia Nacional de Investigacion y Desarrollo (ANID) (Chile) through:
   Anillos de Investigacion en Ciencia y Tecnologia [ACT210006]; Fondo
   Nacional de Investigaciones Cientificas y Tecnologicas (FONDECYT)
   [1210283]; Centro de Gerociencia, Salud Mental y Metabolismo (GERO)
   (FONDAP) [15150012]; Fundacion MAPFRE (Spain) [MAPFRE-2101]
FX This research will be supported by grants from Agencia Nacional de
   Investigacion y Desarrollo (ANID) (Chile) through: Anillos de
   Investigacion en Ciencia y Tecnologia (ACT210006 to PC, CA, RB, FS, GS,
   CGB); Fondo Nacional de Investigaciones Cientificas y Tecnologicas
   (FONDECYT #1210283 to RB, PC, GS); Centro de Gerociencia, Salud Mental y
   Metabolismo (GERO) (FONDAP #15150012 to CGB, FC, FS). Fundacion MAPFRE
   (Spain) Will also provide support through Ayudas a la Investigacion
   Ignacio H. de Larramendi (MAPFRE-2101 to PC, CA, RB, FS, GS, CGB). The
   funders do not have and will not have any no role in study design, data
   collection and analysis, data interpretation, decision to publish or
   preparation of manuscripts from the ObAGE Study.
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NR 60
TC 6
Z9 6
U1 2
U2 16
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2318
J9 BMC GERIATR
JI BMC Geriatr.
PD MAY 2
PY 2022
VL 22
IS 1
AR 387
DI 10.1186/s12877-022-03032-4
PG 11
WC Geriatrics & Gerontology; Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA 0X6IY
UT WOS:000789808800005
PM 35501766
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Hurtado, ACM
   Gonzalez, S
   Syder, NC
   Manasyan, A
   Thompson, T
   Harvey, L
   Rodman, J
   Elbuluk, N
AF Hurtado, Arielle Carolina Mora
   Gonzalez, Sarah
   Syder, Nicole C.
   Manasyan, Arthur
   Thompson, Tiana
   Harvey, Lucy
   Rodman, Jack
   Elbuluk, Nada
TI Comorbidities of Primary Scarring Alopecias: A Retrospective Multi-Site
   Cross-Sectional Study
SO JEADV CLINICAL PRACTICE
LA English
DT Article
DE central centrifugal cicatricial alopecia (CCCA); comorbidities; frontal
   fibrosing alopecia (FFA); lichen planopilaris (LPP); scarring alopecia
ID CENTRIFUGAL CICATRICIAL ALOPECIA; FRONTAL FIBROSING ALOPECIA; METABOLIC
   SYNDROME; LICHEN-PLANOPILARIS; DIABETES-MELLITUS; ASSOCIATION;
   PREVALENCE; CANCER; BREAST
AB Background : To date, limited research has compared the systemic comorbidities of primary scarring alopecia types. Such research may provide insight into shared disease mechanisms, elucidate novel pathways for therapeutics, and identify those most at risk of comorbidities. Objectives: To evaluate the prevalences of systemic comorbidities among scarring alopecia types and compare the prevalence of these comorbidities with national United States prevalence. Methods: A retrospective chart review was conducted investigating the systemic comorbidities in patients with scarring alopecia seen at public and private dermatology clinics in Los Angeles between 2018 and 2022. ResultsA total of 240 patients were identified. Compared to other scarring alopecia types, patients with central centrifugal cicatricial alopecia (CCCA) had an increased risk for concomitant traction alopecia (OR 13.98, p < 0.001), concomitant androgenetic alopecia (OR 3.40, p < 0.001), and vitamin D deficiency (OR 1.97, p = 0.039). Compared to the general US population, patients with scarring alopecia, including CCCA and lichen planopilaris/frontal fibrosing alopecia, had a higher prevalence of vitamin D deficiency, metabolic syndrome, depression, anxiety, thyroid disease, uterine fibroids, anemia, atopy, androgenetic alopecia, and breast cancer. Conclusions: Larger, prospective, population-based studies involving diverse patient groups are needed to differentiate the rates of comorbidities across scarring alopecia types. Dermatologists should consider a thorough review of systems in their patients with scarring alopecia to screen for associated comorbidities, encourage patients to be up to date with age-appropriate screenings, and consider treatment plans that treat associated dermatologic comorbidities along with the primary scarring alopecia.
C1 [Hurtado, Arielle Carolina Mora] Univ Wisconsin, Sch Med & Publ Hlth, Madison, WI USA.
   [Gonzalez, Sarah] Wayne State Univ, Sch Med, Detroit, MI USA.
   [Syder, Nicole C.] Univ Calif San Franscisco, Dept Dermatol, San Francisco, CA USA.
   [Manasyan, Arthur; Thompson, Tiana; Harvey, Lucy] Univ Southern Calif, Keck Sch Med, Los Angeles, CA USA.
   [Rodman, Jack] Southern Calif Clin & Translat Sci Inst, Los Angeles, CA USA.
   [Elbuluk, Nada] Univ Southern Calif, Keck Sch Med, Dept Dermatol, Los Angeles, CA 90007 USA.
C3 University of Wisconsin System; University of Wisconsin Madison; Wayne
   State University; University of California System; University of
   California San Francisco; University of Southern California; University
   of Southern California
RP Elbuluk, N (corresponding author), Univ Southern Calif, Keck Sch Med, Dept Dermatol, Los Angeles, CA 90007 USA.
EM nelbuluk@gmail.com
RI Rodman, Jack/NFT-5379-2025
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NR 75
TC 0
Z9 0
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2768-6566
J9 JEADV CLIN PRACT
JI JEADV Clin. Pract.
PD JUN
PY 2025
VL 4
IS 2
BP 482
EP 494
DI 10.1002/jvc2.70015
EA MAR 2025
PG 13
WC Dermatology
WE Emerging Sources Citation Index (ESCI)
SC Dermatology
GA 3IB8Y
UT WOS:001440037100001
OA gold
DA 2025-06-11
ER

PT J
AU Happell, B
   Hodgetts, D
   Stanton, R
   Millar, F
   Phung, CP
   Scott, D
AF Happell, Brenda
   Hodgetts, Danya
   Stanton, Robert
   Millar, Freyja
   Phung, Chris Platania
   Scott, David
TI Lessons Learned From the Trial of a Cardiometabolic Health Nurse
SO PERSPECTIVES IN PSYCHIATRIC CARE
LA English
DT Article
DE Physical health care; severe mental illness; mental health nursing;
   chronic illness
ID SERIOUS MENTAL-ILLNESS; PHYSICAL HEALTH; RESEARCH PARTICIPATION;
   PERCEIVED BARRIERS; METABOLIC SYNDROME; BIPOLAR DISORDER; PRIMARY-CARE;
   PEOPLE; ATTITUDES; VIEWS
AB PurposeThis paper examines the findings from an exit interview with a cardiometabolic health nurse (CHN) following a 26-week trial.
   Design and MethodsThe CHN participated in a semi-structured exit interview following completion of the 26-week trial. Applied thematic analysis was used to identify themes contained in the resultant transcript.
   FindingsContrary to the literature, the CHN did not consider additional training necessary to undertake the role. The CHN felt additional information regarding the research implications of the trial and greater organizational support would contribute to better consumer and health service outcomes.
   Practice ImplicationsWhile personally rewarding, more can be done to help the CHN role reach its potential.
C1 [Happell, Brenda] Cent Queensland Univ, Ctr Mental Hlth Nursing Innovat, Inst Hlth & Social Sci Res, Sch Nursing & Midwifery,Mental Hlth Nursing, Rockhampton, Qld 4702, Australia.
   [Hodgetts, Danya; Stanton, Robert; Phung, Chris Platania; Scott, David] Cent Queensland Univ, Ctr Mental Hlth Nursing Innovat, Inst Hlth & Social Sci Res, Sch Nursing & Midwifery, Rockhampton, Qld 4702, Australia.
   [Millar, Freyja] Eastern Hlth, Melbourne, Vic, Australia.
   [Scott, David] Univ Melbourne, Northwest Acad Ctr, Melbourne, Vic, Australia.
C3 Central Queensland University; Central Queensland University; Eastern
   Health; University of Melbourne
RP Happell, B (corresponding author), Cent Queensland Univ, Ctr Mental Hlth Nursing Innovat, Inst Hlth & Social Sci Res, Sch Nursing & Midwifery,Mental Hlth Nursing, Rockhampton, Qld 4702, Australia.
EM r.stanton@cqu.edu.au
RI Scott, David/AAE-5031-2021; Stanton, Rob/AAJ-5157-2020; Happell,
   Brenda/HSI-0570-2023
OI Hodgetts, Danya/0000-0003-1433-0273; Scott, David/0000-0001-5226-1972;
   Happell, Brenda/0000-0002-7293-6583
CR [Anonymous], EXPLORATORY RES SOCI
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NR 53
TC 3
Z9 3
U1 0
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0031-5990
EI 1744-6163
J9 PERSPECT PSYCHIATR C
JI Perspect. Psychiatr. Care
PD OCT
PY 2015
VL 51
IS 4
BP 268
EP 276
DI 10.1111/ppc.12091
PG 9
WC Nursing; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Psychiatry
GA CU4AX
UT WOS:000363469500007
PM 25327217
DA 2025-06-11
ER

PT J
AU Simmons, RA
AF Simmons, Rebecca A.
TI Developmental origins of diabetes: The role of oxidative stress
SO BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Article
DE intrauterine growth retardation; type 2 diabetes; Barker hypothesis;
   fetal origins of adult disease
ID PANCREATIC BETA-CELLS; INTRAUTERINE GROWTH-RETARDATION;
   LOW-BIRTH-WEIGHT; SIGNALING PROTEIN EXPRESSION; THRIFTY PHENOTYPE
   HYPOTHESIS; INSULIN-RESISTANCE SYNDROME; IMPAIRED GLUCOSE-TOLERANCE;
   ENZYME GENE-EXPRESSION; FETAL-GROWTH; HYDROXYSTEROID DEHYDROGENASE
AB The 'thrifty phenotype' hypothesis proposes that the fetus adapts to an adverse intrauterine milieu by optimizing the use of a reduced, nutrient supply to ensure survival, but by favoring the development of certain organs over that of others, this leads to persistent alterations in the growth and function of developing tissues. This concept has been somewhat controversial, however recent epidemiological, clinical, and animal studies provide support for the developmental origins of disease hypothesis. Underlying mechanisms include reprogramming of the hypothalamic-pituitary-adrenal axis, islet development, and insulin signaling pathways. Emerging data suggests that oxidative stress and mitochondrial dysfunction may also play a critical role in the pathogenesis of type 2 diabetes in individuals who were growth retarded at birth. (C) 2012 Elsevier Ltd. All rights reserved.
C1 [Simmons, Rebecca A.] Childrens Hosp Philadelphia, Dept Pediat, Philadelphia, PA 19104 USA.
   [Simmons, Rebecca A.] Univ Penn, Philadelphia, PA 19104 USA.
C3 University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of
   Philadelphia; University of Pennsylvania
RP Simmons, RA (corresponding author), Childrens Hosp Philadelphia, Dept Pediat, BRB 2-3,Rm 1308,421 Curie Blvd, Philadelphia, PA 19104 USA.
EM rsimmons@mail.med.upenn.edu
OI Simmons, Rebecca/0000-0002-2901-8904
FU NIDDK NIH HHS [R01 DK055704] Funding Source: Medline
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NR 93
TC 40
Z9 46
U1 2
U2 20
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1521-690X
EI 1532-1908
J9 BEST PRACT RES CL EN
JI Best Pract. Res. Clin. Endoc. Metab.
PD OCT
PY 2012
VL 26
IS 5
BP 701
EP 708
DI 10.1016/j.beem.2012.03.012
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 017DT
UT WOS:000309571000012
PM 22980051
OA Green Accepted
DA 2025-06-11
ER

PT S
AU Kramer, H
AF Kramer, Holly
BE Wolf, G
TI Obesity and chronic kidney disease
SO OBESITY AND THE KIDNEY
SE Contributions to Nephrology
LA English
DT Article
ID BODY-MASS INDEX; FOCAL SEGMENTAL GLOMERULOSCLEROSIS; GROWTH-FACTOR-BETA;
   INSULIN-RESISTANCE SYNDROME; MEDIATED GLOMERULAR INJURY; STAGE
   RENAL-DISEASE; NEPHROTIC SYNDROME; METABOLIC SYNDROME; WEIGHT-LOSS;
   CARDIOVASCULAR RISK
AB Background/Aims: The prevalence of obesity among U.S. adults has doubled within the past two decades, and if trends continue, over one-third of U.S. adults may be obese by the year 2008. Concurrent with the rising prevalence of obesity is an epidemic of chronic kidney disease (CKD) with an estimated 18 million U.S. adults currently affected. This review discusses the strong and consistent association between CKD risk and increasing body mass index noted in several observational studies. Potential mechanisms for obesity's role in the development and progression of CKD and secondary focal segmental glomerulosclerosis are also discussed. Methods: Literature review. Results: Although obesity is an important risk factor for diabetes and hypertension, the two most common etiologies of kidney failure, obesity itself may increase CKD risk by increasing the metabolic demands on the kidney, which leads to higher glomerular capillary pressures and glomerular hypertrophy. The hyperinsulinemia frequently linked with obesity may also accelerate structural damage by interacting with angiotensin 11 and increasing collagen production and deposition. The histologic changes in the kidney noted in some obese, especially morbidly obese, adults frequently mimic those changes associated with secondary focal segmental glomerulosclerosis, which may occur in disease states such as severely reduced nephron mass and hemodynamic stress. Given the presence of genetic susceptibility and/or reduced nephron mass, obesity may potentiate the development and progression of secondary focal segmental glomerulosclerosis. Conclusions: Obesity is an important risk factor for CKD. Treatment plans for obese adults with CKD should include weight loss and exercise because these interventions may simultaneously reduce the metabolic demands on the kidney, lower systemic and glomerular pressures, and improve insulin sensitivity. However, more studies are needed to further optimize the treatment and prevention of CKD associated with obesity. Copyright (c) 2006 S. Karger AG, Basel.
C1 Loyola Univ, Ctr Med, Dept Prevent Med, Maywood, IL 60153 USA.
   Loyola Univ, Ctr Med, Dept Med, Maywood, IL 60153 USA.
C3 Loyola University Chicago; Loyola University Chicago
RP Kramer, H (corresponding author), Loyola Univ, Ctr Med, Dept Prevent Med, 2160 1st Ave, Maywood, IL 60153 USA.
EM HKramer@lumc.edu
OI Kramer, Holly/0000-0002-6374-837X
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NR 97
TC 47
Z9 54
U1 0
U2 7
PU KARGER
PI BASEL
PA POSTFACH, CH-4009 BASEL, SWITZERLAND
SN 0302-5144
EI 1662-2782
BN 3-8055-8164-5
J9 CONTRIB NEPHROL
JI Contrib.Nephrol.
PY 2006
VL 151
BP 1
EP 18
PG 18
WC Endocrinology & Metabolism; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Urology & Nephrology
GA BFK92
UT WOS:000242544900001
PM 16929130
DA 2025-06-11
ER

PT J
AU Jovanovic, J
   Sarac, I
   Jovanovic, S
   Sokolovic, D
   Govedarovic, N
   Jovanovic, J
AF Jovanovic, Jovana
   Sarac, Ivana
   Jovanovic, Stefan
   Sokolovic, Dusan
   Govedarovic, Nenad
   Jovanovic, Jovica
TI The relationship between occupational stress, health status, and
   temporary and permanent work disability among security guards in Serbia
SO INTERNATIONAL JOURNAL OF OCCUPATIONAL SAFETY AND ERGONOMICS
LA English
DT Article
DE occupational stress; health; disease; work disability; security guards
ID IMPAIRED FASTING GLUCOSE; PITUITARY-ADRENAL AXIS; METABOLICALLY-OBESE;
   JOB STRESS; PSYCHOLOGICAL DISTRESS; CARDIOVASCULAR RISK; POLICE
   OFFICERS; PROFESSIONAL DRIVERS; LIPOPROTEIN RATIOS; CHOLESTEROL RATIO
AB Purpose. This study aimed to examine the influence of occupational stress on health status and work disability among security guards in Serbia. Methods. Three hundred and ninty nine male security guards (aged 25-65 years) were examined during regular medical preventive check-ups at the Institute of Occupational Health. Data on their health status and permanent and temporary work disability were obtained, and correlations with the levels of occupational stress (measured by occupational stress index [OSI] questionnaire) were analysed. Results. A high prevalence of health impairments, including diabetes (38.8%), dyslipidaemia (82.7%), hypertension (69.9%) and metabolic syndrome (77.7%), was found. Highly significant correlations were shown between reported levels of total stress at work (total OSI score) and measured values of glucose, lipids, blood pressure, heart rate, Framingham cardiovascular risk scale, occurrence of diabetes and impaired fasting glucose, dyslipidaemia, hypertension, metabolic syndrome, coronary heart disease, cerebrovascular insults, degenerative eye-fundus changes, and temporary and permanent work disability. All of these correlations remained significant even after adjustments for age, body mass index and smoking status. Regression analysis confirmed the independent effect of occupational stress on the analysed parameters. Conclusions. There is a significant independent impact of occupational stress on development of health impairments and work disability among security guards.
C1 [Jovanovic, Jovana; Jovanovic, Stefan; Jovanovic, Jovica] Univ Nis, Dept Occupat Hlth, Nish, Serbia.
   [Sarac, Ivana] Univ Belgrade, Inst Med Res, Ctr Res Excellence Field Nutr & Metab, Belgrade, Serbia.
   [Sokolovic, Dusan] Univ Nis, Dept Biochem, Nish, Serbia.
   [Govedarovic, Nenad] Univ Nis, Dept Internal Med, Nish, Serbia.
   [Jovanovic, Jovica] Univ Nis, Inst Occupat Med Nis, Nish, Serbia.
C3 University of Nis; University of Belgrade; University of Nis; University
   of Nis; University of Nis
RP Sarac, I (corresponding author), Univ Belgrade, Inst Med Res, Ctr Res Excellence Field Nutr & Metab, Belgrade, Serbia.
EM ivanasarac@yahoo.com
RI Šarac, Ivana/ABR-2387-2022
OI Govedarovic, Nenad/0000-0001-6741-1494; Sarac,
   Ivana/0000-0003-1439-9561; Sokolovic, Dusan/0000-0001-6586-6428
FU Ministry of Education, Science and Technological Development of the
   Republic of Serbia [III41030, III43012]; Faculty of Medicine, University
   of Nis [INT8]
FX The study received financial support from Ministry of Education, Science
   and Technological Development of the Republic of Serbia [project numbers
   III41030 and III43012, 2011-2017]; and Faculty of Medicine, University
   of Nis [project number INT8, 2017-2019].
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NR 131
TC 10
Z9 10
U1 1
U2 23
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1080-3548
EI 2376-9130
J9 INT J OCCUP SAF ERGO
JI Int. J. Occup. Saf. Ergon.
PD APR 3
PY 2021
VL 27
IS 2
BP 425
EP 441
DI 10.1080/10803548.2019.1579458
EA APR 2019
PG 17
WC Ergonomics; Public, Environmental & Occupational Health
WE Social Science Citation Index (SSCI)
SC Engineering; Public, Environmental & Occupational Health
GA RW2ZJ
UT WOS:000465798700001
PM 30735105
DA 2025-06-11
ER

PT J
AU Almadi, T
   Cathers, I
   Chow, CM
AF Almadi, Tawfiq
   Cathers, Ian
   Chow, Chin Moi
TI Associations among work-related stress, cortisol, inflammation, and
   metabolic syndrome
SO PSYCHOPHYSIOLOGY
LA English
DT Article
DE Psychopathological; Biochemical
ID C-REACTIVE PROTEIN; EFFORT-REWARD IMBALANCE; INSULIN-RESISTANCE;
   PHYSICAL-ACTIVITY; DEPRESSIVE SYMPTOMS; SALIVARY CORTISOL; PERCEIVED
   STRESS; NATIONAL-HEALTH; ADIPOSE-TISSUE; SLEEP QUALITY
AB This cross-sectional study examined the relationship between work-related stress, cortisol, and C-reactive protein (CRP) in predicting metabolic syndrome (MtS). Self-reported work stress measured by the effort reward imbalance ratio (ERI), anthropometric data, CRP, and saliva cortisol were collected from 204 healthy Jordanian male workers. ERI and cortisol were significantly associated with the presence of MtS (OR=4.74, 95% CI: 2.13-10.55; OR=3.03, 95% CI: 2.08-4.40; OR=11.50, 95% CI: 2.16-59.14, respectively). The odds of MtS in men with high ERI and high cortisol were significantly higher than that of men with low ERI and low cortisol (OR=11.50, 95% CI: 2.16-59.14). CRP was significantly associated with MtS (OR=2.51, 95% CI: 1.50-4.20). The odds of MtS were significantly higher in centrally obese men with both high ERI and CRP level. Thus, high ERI along with high cortisol or high CRP increases the risk for MtS, especially among centrally obese men.
C1 [Almadi, Tawfiq; Cathers, Ian; Chow, Chin Moi] Univ Sydney, Discipline Exercise & Sport Sci, Fac Hlth Sci, Lidcombe, NSW 1825, Australia.
C3 University of Sydney
RP Almadi, T (corresponding author), Univ Sydney, Discipline Exercise & Sport Sci, Fac Hlth Sci, POB 170, Lidcombe, NSW 1825, Australia.
EM talm3809@uni.sydney.edu.au
RI Chow, Chin Moi/B-2971-2013
OI Chow, Chin Moi/0000-0001-9916-9882
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NR 75
TC 64
Z9 73
U1 0
U2 29
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0048-5772
EI 1469-8986
J9 PSYCHOPHYSIOLOGY
JI Psychophysiology
PD SEP
PY 2013
VL 50
IS 9
BP 821
EP 830
DI 10.1111/psyp.12069
PG 10
WC Psychology, Biological; Neurosciences; Physiology; Psychology;
   Psychology, Experimental
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Neurosciences & Neurology; Physiology
GA 201GU
UT WOS:000323129500001
PM 23758414
DA 2025-06-11
ER

PT J
AU Parikh, N
   Ahmad, J
AF Parikh, Neil
   Ahmad, Jawad
TI Nonalcoholic Fatty Liver Disease: Pharmacologic and Surgical Options
SO GASTROENTEROLOGY CLINICS OF NORTH AMERICA
LA English
DT Article
DE Nonalcoholic fatty liver disease; Nonalcoholic steatohepatitis;
   Pioglitazone; Vitamin E; Bariatric surgery
ID PLACEBO-CONTROLLED TRIAL; DOSE URSODEOXYCHOLIC ACID; VITAMIN-E;
   WEIGHT-LOSS; INTRAGASTRIC BALLOON; INSULIN-RESISTANCE; METABOLIC
   SYNDROME; BARIATRIC SURGERY; HEPATIC STEATOSIS; ALPHA-TOCOPHEROL
AB Non-alcoholic fatty liver disease (NAFLD) encompasses a spectrum of hepatic steatosis, inflammation and fibrosis that can lead to cirrhosis and the need for liver transplant. NAFLD can be considered as part of the metabolic syndrome as it typically occurs in obese subjects with insulin resistance. Pharmacologic approaches to NAFLD therapy include improving insulin resistance and decreasing oxidative stress, while conservative and surgical weight loss strategies have also shown some promise. However, further well designed prospective studies are required to determine the optimal therapy in NAFLD.
C1 [Ahmad, Jawad] Mt Sinai Sch Med, Div Liver Dis, New York, NY 10029 USA.
   [Parikh, Neil] Mt Sinai Sch Med, Div Internal Med, New York, NY 10029 USA.
C3 Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at
   Mount Sinai
RP Ahmad, J (corresponding author), Mt Sinai Sch Med, Div Liver Dis, 1 Gustave L Levy Pl, New York, NY 10029 USA.
EM javbob@hotmail.com
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NR 89
TC 2
Z9 2
U1 1
U2 5
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0889-8553
EI 1558-1942
J9 GASTROENTEROL CLIN N
JI Gastroenterol. Clin. North Am.
PD SEP
PY 2011
VL 40
IS 3
BP 541
EP +
DI 10.1016/j.gtc.2011.06.001
PG 20
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 828ZY
UT WOS:000295545400006
PM 21893273
DA 2025-06-11
ER

PT J
AU Ellulu, MS
AF Ellulu, Mohammed S.
TI Obesity, cardiovascular disease, and role of vitamin C on inflammation:
   a review of facts and underlying mechanisms
SO INFLAMMOPHARMACOLOGY
LA English
DT Review
DE Obesity; Cardiovascular disease; Metabolic syndrome; Inflammation;
   Oxidative stress; Thrombosis; Nitric oxide; Antioxidant; Vitamin C;
   Ascorbic acid
ID BODY-MASS INDEX; INCREASED OXIDATIVE STRESS; TYPE-2 DIABETES-MELLITUS;
   REACTIVE PROTEIN; METABOLIC-SYNDROME; ASCORBIC-ACID; RISK-FACTORS;
   SYSTEMIC INFLAMMATION; UNITED-STATES; ENDOTHELIAL FUNCTION
AB Obesity means the accumulation of excessive fat that may interfere with the maintenance of optimal state of health. Obesity causes cardiac and vascular disease through well-known mediators such as hypertension, type-2 diabetes mellitus, and dyslipidemia, but there are evidences for other mediators such as chronic inflammation, oxidative stress, and thrombosis. The decreased levels of antioxidants factors and nitric oxide predispose to further cardiovascular adverse events. To reduce the risks, antioxidants can help by neutralizing the free radicals and protecting from damage by donating electrons. Having the capacity, vitamin C protects from oxidative stress, prevention of non-enzymatic glycosylation of proteins, and enhances arterial dilation through its effect on nitric oxide release. It also decreases lipid peroxidation, and alleviates inflammation. The anti-inflammatory property of vitamin C could be attributed to ability to modulate the NF-kB DNA binding activity and down-regulation in the hepatic mRNA expression for the interleukins and tumor factors.
C1 [Ellulu, Mohammed S.] Univ Putra Malaysia, Dept Nutr & Dietet, Fac Med & Hlth Sci, Serdang, Selangor, Malaysia.
C3 Universiti Putra Malaysia
RP Ellulu, MS (corresponding author), Univ Putra Malaysia, Dept Nutr & Dietet, Fac Med & Hlth Sci, Serdang, Selangor, Malaysia.
EM mohdsubhilulu@gmail.com
RI Ellulu, Mohammed S./O-4466-2014
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NR 145
TC 55
Z9 58
U1 0
U2 37
PU SPRINGER BASEL AG
PI BASEL
PA PICASSOPLATZ 4, BASEL, 4052, SWITZERLAND
SN 0925-4692
EI 1568-5608
J9 INFLAMMOPHARMACOLOGY
JI Inflammopharmacology
PD JUN
PY 2017
VL 25
IS 3
BP 313
EP 328
DI 10.1007/s10787-017-0314-7
PG 16
WC Immunology; Pharmacology & Pharmacy; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Pharmacology & Pharmacy; Toxicology
GA EV5PF
UT WOS:000401818900003
PM 28168552
DA 2025-06-11
ER

PT J
AU Wright, T
   Fenton, A
   Ling, CTRE
   Tromba, S
AF Wright, Tracy
   Fenton, Ashley
   Ling, Catherine
   Tromba, Sara
TI Implementing Lifestyle Interventions for Adults With Mental Illness via
   Telemedicine
SO JNP- THE JOURNAL FOR NURSE PRACTITIONERS
LA English
DT Article
DE mental health; metabolic syndrome; primary care; psychiatric nursing;
   telehealth; wellness
AB Individuals with psychiatric illnesses have shorter life expectancies due to increased obesity, diabetes, and hypertension. Modifiable factors such as diet, exercise, and weight control are essential but often underutilized in clinical practice. This quality improvement project evaluated a 9-week, evidence-based lifestyle education program aimed at enhancing self-care and health outcomes among adults with psychiatric illness at risk of cardiometabolic conditions in a telemental primary care setting. A pretest-posttest design assessed self-care inventory scores, health indicators, and program feasibility. Results showed improvements in weight, body mass index, and self-care confidence, emphasizing the critical role of nurse practitioners in telemedicine. (c) 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.
C1 [Wright, Tracy; Fenton, Ashley; Ling, Catherine; Tromba, Sara] Johns Hopkins Univ, Sch Nursing, Baltimore, MD 21205 USA.
C3 Johns Hopkins University
RP Wright, T (corresponding author), Johns Hopkins Univ, Sch Nursing, Baltimore, MD 21205 USA.
EM twrigh64@alumni.jh.edu
OI Fenton, Ashley/0000-0001-6616-6458
CR Agency for Healthcare Research and Quality, 2019, Disparities within serious mental illness
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NR 29
TC 0
Z9 0
U1 2
U2 2
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1555-4155
EI 1878-058X
J9 JNP-J NURSE PRACT
JI JNP-J. Nurse Pract.
PD MAR
PY 2025
VL 21
IS 3
AR 105302
DI 10.1016/j.nurpra.2024.105302
EA MAR 2025
PG 6
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA Z9S8C
UT WOS:001442224800001
DA 2025-06-11
ER

PT J
AU Kloster, A
   Hyer, MM
   Dyer, S
   Salome-Sanchez, C
   Neigh, GN
AF Kloster, Alix
   Hyer, Molly M.
   Dyer, Samya
   Salome-Sanchez, Charlie
   Neigh, Gretchen N.
TI High Fructose Diet Induces Sex-specific Modifications in Synaptic
   Respiration and Affective-like Behaviors in Rats
SO NEUROSCIENCE
LA English
DT Article
DE metabolism; mitochondria; sex differences; fructose; anxiety; depression
ID OXIDATIVE STRESS; METABOLIC SYNDROME; SWEETENED BEVERAGES;
   SOCIAL-INTERACTION; BODY-WEIGHT; FOOD-INTAKE; OPEN-FIELD; US ADULTS;
   GLUCOSE; DEPRESSION
AB consequences of excessive fructose intake extend beyond those of metabolic disorder to changes in emotional regulation and cognitive function. Long-term consumption of fructose, particularly common when begun in adolescence, is more likely to lead to deleterious consequences than acute consumption. These long-term consequences manifest differently in males and females, suggesting a sex-divergent mechanism by which fructose can impair physiology and neural function. The purpose of the current project was to investigate a possible sex-specific mechanism by which elevated fructose consumption drives behavioral deficits and accompanying metabolic symptoms - specifically, synaptic mitochondrial function. Male and female rats were fed a high fructose diet beginning at weaning and maintained into adulthood. Measures of physiological health across the diet consumption period indicated that females were more likely to gain weight than males while both displayed increased circulating blood glucose. As adults, females fed the high fructose diet displayed increased floating behavior in the forced swim task while males exhibited increased exploratory behavior in the open field. Synaptic respiration was altered by diet in both females and males but the effect was sex-divergent - fructose-fed females had increased synaptic respiration while males showed a decrease. When exposed to an acute energetic challenge, the pattern was reversed. Taken together, these data indicate that diet-induced alterations to neural function and physiology are sex-specific and highlight the need to consider sex as a biological variable when treating metabolic disease. Furthermore, these data suggest that synaptic mitochondrial function may contribute directly to the behavioral consequences of elevated fructose consumption. This article is part of a Special Issue entitled: Lifestyle and Brain Metaplasticity. (c) 2019 IBRO. Published by Elsevier Ltd. All rights reserved.
C1 [Kloster, Alix; Hyer, Molly M.; Dyer, Samya; Salome-Sanchez, Charlie; Neigh, Gretchen N.] Virginia Commonwealth Univ, Dept Anat & Neurobiol, Richmond, VA 23298 USA.
C3 Virginia Commonwealth University
RP Neigh, GN (corresponding author), Virginia Commonwealth Univ, Anat & Neurobiol, Sanger Hall Rm 12-044,1101 E Marshall St, Richmond, VA 23298 USA.
EM gretchen.mccandless@vcuhealth.org
RI Neigh, Gretchen/AAW-5691-2020; Neigh, Gretchen/G-3662-2011
OI Neigh, Gretchen/0000-0003-0955-9161; Hyer, Molly/0000-0001-7687-2030
FU National Institute of Nursing Research USA [NR014886]
FX National Institute of Nursing Research NR014886 USA
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NR 72
TC 14
Z9 14
U1 2
U2 7
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4522
EI 1873-7544
J9 NEUROSCIENCE
JI Neuroscience
PD FEB 1
PY 2021
VL 454
SI SI
BP 40
EP 50
DI 10.1016/j.neuroscience.2019.11.039
EA JAN 2021
PG 11
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA PX2FW
UT WOS:000611177900004
PM 31881260
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Zsoldos, E
   Filippini, N
   Mahmood, A
   Mackay, CE
   Singh-Manoux, A
   Kivimäki, M
   Jenkinson, M
   Ebmeier, KP
AF Zsoldos, Eniko
   Filippini, Nicola
   Mahmood, Abda
   Mackay, Clare E.
   Singh-Manoux, Archana
   Kivimaki, Mika
   Jenkinson, Mark
   Ebmeier, Klaus P.
TI Allostatic load as a predictor of grey matter volume and white matter
   integrity in old age: The Whitehall II MRI study
SO SCIENTIFIC REPORTS
LA English
DT Article
ID CUMULATIVE BIOLOGICAL RISK; CEREBRAL-ARTERY TERRITORY;
   CORONARY-HEART-DISEASE; METABOLIC SYNDROME; PHYSIOLOGICAL DYSREGULATION;
   CORTICAL THICKNESS; WORK STRESS; ALL-CAUSE; BRAIN; HEALTH
AB The allostatic load index quantifies the cumulative multisystem physiological response to chronic everyday stress, and includes cardiovascular, metabolic and inflammatory measures. Despite its central role in the stress response, research of the effect of allostatic load on the ageing brain has been limited. We investigated the relation of mid-life allostatic load index and multifactorial predictors of stroke (Framingham stroke risk) and diabetes (metabolic syndrome) with voxelwise structural grey and white matter brain integrity measures in the ageing Whitehall II cohort (N = 349, mean age = 69.6 (SD 5.2) years, N (male) = 281 (80.5%), mean follow-up before scan = 21.4 (SD 0.82) years). Higher levels of all three markers were significantly associated with lower grey matter density. Only higher Framingham stroke risk was significantly associated with lower white matter integrity (low fractional anisotropy and high mean diffusivity). Our findings provide some empirical support for the concept of allostatic load, linking the effect of everyday stress on the body with features of the ageing human brain.
C1 [Zsoldos, Eniko; Filippini, Nicola; Mahmood, Abda; Mackay, Clare E.; Ebmeier, Klaus P.] Univ Oxford, Warneford Hosp, Dept Psychiat, Oxford OX3 7JX, England.
   [Zsoldos, Eniko; Filippini, Nicola; Jenkinson, Mark] Univ Oxford, Oxford Ctr Funct MRI Brain, Wellcome Ctr Integrat Neuroimaging, Nuffield Dept Clin Neurosci,John Radcliffe Hosp, Oxford OX3 9DU, England.
   [Mackay, Clare E.] Univ Oxford, Warneford Hosp, Wellcome Ctr Integrat Neuroimaging, Oxford Ctr Human Brain Act, Oxford OX3 7JX, England.
   [Singh-Manoux, Archana; Kivimaki, Mika] UCL, Dept Epidemiol & Publ Hlth, London WC1E 7HB, England.
   [Singh-Manoux, Archana] INSERM, Ctr Res Epidemiol & Populat Hlth, U1018, F-94807 Villejuif, France.
C3 University of Oxford; University of Oxford; University of Oxford;
   University of London; University College London; Universite Paris
   Saclay; Institut National de la Sante et de la Recherche Medicale
   (Inserm)
RP Zsoldos, E (corresponding author), Univ Oxford, Warneford Hosp, Dept Psychiat, Oxford OX3 7JX, England.; Zsoldos, E (corresponding author), Univ Oxford, Oxford Ctr Funct MRI Brain, Wellcome Ctr Integrat Neuroimaging, Nuffield Dept Clin Neurosci,John Radcliffe Hosp, Oxford OX3 9DU, England.
EM eniko.zsoldos@psych.ox.ac.uk
RI Jenkinson, Mark/AAC-8861-2019; Kivimaki, Mika/B-3607-2012; Filippini,
   Nicola/Q-5250-2019; Ebmeier, Klaus/B-4789-2008; Filippini,
   Nicola/H-6869-2013; Singh-Manoux, Archana/F-6804-2013
OI Mackay, Clare/0000-0001-6111-8318; Filippini,
   Nicola/0000-0003-1513-5269; Singh-Manoux, Archana/0000-0002-1244-5037;
   Kivimaki, Mika/0000-0002-4699-5627; Ebmeier, Klaus
   P./0000-0002-5190-7038; Mahmood, Abda/0000-0002-3267-4590; Zsoldos,
   Eniko/0000-0002-0478-6165
FU "Lifelong Health and Wellbeing" Programme Grant: "Predicting MRI
   abnormalities with longitudinal data of the Whitehall II Substudy" (UK
   Medical Research Council) [G1001354]; HDH Wills 1965 Charitable Trust
   [1117747]; US National Institutes of Health [R01AG013196, R01AG034454];
   UK Medical Research Council [K013351]; ESRC/NordForsk professional
   fellowship scheme; National Institute for Health Research (NIHR)
   Biomedical Research Centres (BRC) based at Oxford Health NHS Foundation
   Trust; Oxford University Hospitals Foundation Trust; University of
   Oxford; MRC [MR/K013351/1, MC_EX_MR/N50192X/1, MR/R024227/1,
   MR/L023784/1, G1001354, MR/M024962/1] Funding Source: UKRI
FX We thank all Whitehall II participants for their time, the Whitehall II
   staff at the University College London and the FMRIB staff, Wellcome
   Centre for Integrative Neuroimaging for their helpful collaboration.
   Work on the Whitehall II imaging sub-study was funded by the "Lifelong
   Health and Wellbeing" Programme Grant: "Predicting MRI abnormalities
   with longitudinal data of the Whitehall II Substudy" (UK Medical
   Research Council: G1001354, PI: KPE), and the HDH Wills 1965 Charitable
   Trust (Nr: 1117747, PI: KPE). AS-M receives research support from the US
   National Institutes of Health (R01AG013196, R01AG034454). MK is
   supported by the UK Medical Research Council (K013351), and the
   ESRC/NordForsk professional fellowship scheme. CEM and MJ are supported
   by the National Institute for Health Research (NIHR) Biomedical Research
   Centres (BRC) based at Oxford Health NHS Foundation Trust, and at Oxford
   University Hospitals Foundation Trust in partnership with the University
   of Oxford, respectively.
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NR 75
TC 29
Z9 33
U1 0
U2 8
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD APR 23
PY 2018
VL 8
AR 6411
DI 10.1038/s41598-018-24398-9
PG 11
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA GD5IB
UT WOS:000430539500047
PM 29686319
OA Green Published, Green Accepted, gold
DA 2025-06-11
ER

PT J
AU Xiong, Q
   Liu, J
   Xu, YC
AF Xiong, Qing
   Liu, Jie
   Xu, Yancheng
TI Effects of Uric Acid on Diabetes Mellitus and Its Chronic Complications
SO INTERNATIONAL JOURNAL OF ENDOCRINOLOGY
LA English
DT Review
ID C-REACTIVE PROTEIN; METABOLIC SYNDROME; KIDNEY-DISEASE;
   HOSPITALIZED-PATIENTS; BLOOD-PRESSURE; ENDOTHELIAL DYSFUNCTION;
   MENDELIAN RANDOMIZATION; PERIPHERAL NEUROPATHY; INCREASED PREVALENCE;
   ATRIAL-FIBRILLATION
AB With the deepening of the researches on uric acid, especially in the study of metabolic diseases, uric acid has been found to be closely related to obesity, metabolic syndrome, nonalcoholic fatty liver disease, diabetes, and other metabolic diseases. Uric acid causes a series of pathophysiological changes through inflammation, oxidative stress, vascular endothelial injury, and so on and thus subsequently promotes the occurrence and development of diseases. This review confirmed the positive correlation between uric acid and diabetes mellitus and its chronic complications through the pathogenesis and clinical studies aspects.
C1 [Xiong, Qing; Liu, Jie; Xu, Yancheng] Wuhan Univ, Dept Endocrinol, Zhongnan Hosp, Wuhan 430071, Hubei, Peoples R China.
   [Xiong, Qing] Cent South Univ, Xiangya Med Coll, Dept Endocrinol, Affiliated Haikou Hosp, Haikou 570208, Hainan, Peoples R China.
C3 Wuhan University
RP Xu, YC (corresponding author), Wuhan Univ, Dept Endocrinol, Zhongnan Hosp, Wuhan 430071, Hubei, Peoples R China.
EM qingqingkl@163.com; 89500076@qq.com; xjl100901@whu.edu.cn
OI Xiong, Qing/0000-0003-3790-652X; Xu, Yancheng/0000-0002-3298-5110
FU National Natural Science Foundation of China [81370872]
FX This study was supported by the National Natural Science Foundation of
   China (no. 81370872). The authors are indebted to the Department of
   Endocrinology, Zhongnan Hospital of Wuhan University, for providing
   suggestion during the preparation of the manuscript.
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NR 102
TC 83
Z9 89
U1 2
U2 23
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1687-8337
EI 1687-8345
J9 INT J ENDOCRINOL
JI Int. J. Endocrinol.
PD OCT 13
PY 2019
VL 2019
AR 9691345
DI 10.1155/2019/9691345
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA JH9OB
UT WOS:000493096700001
PM 31737070
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Andrade, C
AF Andrade, Chittaranjan
TI Primary prevention of cardiovascular events in patients with major
   mental illness: a possible role for statins
SO BIPOLAR DISORDERS
LA English
DT Review
DE atypical antipsychotics; bipolar disorder; cardiovascular disease;
   metabolic syndrome; primary prevention; schizophrenia; statins
ID RANDOMIZED CONTROLLED-TRIALS; PLACEBO-CONTROLLED TRIAL; GENERALIZED
   ANXIETY DISORDER; BIPOLAR DISORDER; HEALTHY-MEN; METABOLIC SYNDROME;
   LOW-RISK; ANTIPSYCHOTIC MEDICATIONS; PHARMACOLOGICAL-TREATMENT;
   ROSUVASTATIN-JUPITER
AB ObjectivesTo examine the need for and the possible benefits and risks of statin therapy in patients with major mental illness.
   MethodsPatients with psychiatric conditions, especially those with major mental illnesses such as schizophrenia and bipolar disorder, are at increased risk of overweight, obesity, dyslipidemia, diabetes mellitus, and the metabolic syndrome, all of which increase the risk of cardiovascular disease, cerebrovascular disease, and mortality. The literature on the subject was qualitatively reviewed.
   ResultsPrimary prevention benefits with statins are well known in the general population of high-risk patients; recent evidence suggests that statins also carry primary prevention benefits in low-risk subjects. Regrettably, the primary prevention of cardiovascular and cerebrovascular events in psychiatry is a neglected area in clinical practice as well as in interventional research, whether in high- or in low-risk patients. Initial concerns notwithstanding, psychiatric complications do not appear to be important among the adverse effects of statins. Although statins are associated with an increased risk of incident diabetes mellitus, myopathy, and other untoward consequences, the risk-benefit ratio appears to favor statin use. The advisability of using statins in low-risk or medically healthy subjects remains debatable.
   ConclusionsOverweight, obesity, dyslipidemia, diabetes mellitus, and the metabolic syndrome are common in patients with major mental illness, and these increase the risk of medical morbidity and mortality. Statin use should therefore be considered for the primary prevention of cardiovascular and cerebrovascular events in psychiatric patients, especially in those at high risk.
C1 Natl Inst Mental Hlth & Neurosci, Dept Psychopharmacol, Bangalore 560029, Karnataka, India.
C3 National Institute of Mental Health & Neurosciences - India
RP Andrade, C (corresponding author), Natl Inst Mental Hlth & Neurosci, Dept Psychopharmacol, Bangalore 560029, Karnataka, India.
EM andradec@gmail.com
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NR 103
TC 20
Z9 20
U1 0
U2 17
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1398-5647
EI 1399-5618
J9 BIPOLAR DISORD
JI Bipolar Disord.
PD DEC
PY 2013
VL 15
IS 8
BP 813
EP 823
DI 10.1111/bdi.12130
PG 11
WC Clinical Neurology; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA 262NL
UT WOS:000327742200001
PM 24119211
DA 2025-06-11
ER

PT J
AU da Silva, DAR
   de Almeida, LS
   Correa, LL
   Pimentel, RFW
   Gomes, AMT
   Travassos, AG
   Viana, AM
   Cerqueira, MMBD
   de Souza, MC
   de Sousa, AR
   Barbosa, PJB
   Coelho, JMF
   Magalhaes, LBNC
   Júnior, AD
   Neto, JLC
   Santos, CS
   França, LCM
   Brandao, JD
   dos Santos, LFD
   Gomes, HF
   Peres, EM
   Rossi, TRA
   Damasceno, KSM
   das Mercês, MC
   Fernandes, SL
   Soriano, ED
   Maduro, IPDN
   Brandao, TS
   Menezes, AC
   Santana, AIC
   das Merces, MC
AF Reis da Silva, Dandara Almeida
   de Almeida, Ludmila Santana
   Correa, Livia Lugarinho
   Pimentel, Rodrigo Fernandes Weyll
   Gomes, Antonio Marcos Tosoli
   Travassos, Ana Gabriela
   Viana, Adriana Mattos
   Cerqueira, Monique Magnavita Borba da Fonseca
   de Souza, Marcio Costa
   de Sousa, Anderson Reis
   Barbosa, Paulo Jose Bastos
   Coelho, Julita Maria Freitas
   Magalhaes, Lucelia Batista Neves Cunha
   D'Oliveira Junior, Argemiro
   Cavalcante Neto, Jorge Lopes
   Santos, Charles Souza
   Franca, Luiz Carlos Moraes
   Brandao, Juliana de Lima
   dos Santos, Livia Fajin de Mello
   Gomes, Helena Ferraz
   Peres, Ellen Marcia
   Rossi, Thais Regis Aranha
   Damasceno, Kairo Silvestre Meneses
   das Merces, Millena Conceicao
   Fernandes, Sandra Lucia
   Soriano, Eline de Almeida
   Maduro, Isolda Prado de Negreiros Nogueira
   Brandao, Tatiana Santos
   Menezes, Amanda Cardoso
   Santana, Amalia Ivine Costa
   das Merces, Magno Conceicao
TI Prevalence and Factors Associated with Metabolic Syndrome in Patients at
   a Psychosocial Care Center: A Cross-Sectional Study
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Article
DE metabolic syndrome; mental disorders; obesity; multimorbidity
ID HYPERTRIGLYCERIDEMIC-WAIST; PHYSICAL MULTIMORBIDITY; RISK; PEOPLE;
   COMPONENTS; DISORDERS; HEALTH
AB Background: Metabolic syndrome (MS) is associated with greater risk of morbimortality and it has high prevalence in people with mental illness. Objective: Estimate the prevalence of Metabolic Syndrome (MS) and its associated factors in the patients of a Psychosocial Care Center (CAPS in Brazilian Portuguese) in the city of Salvador, state of Bahia, Brazil. Method: Cross-sectional study set at CAPS in the city of Salvador-Bahia between August 2019 and February 2020. MS was evaluated according to the National Cholesterol Education Program's Adult Treatment Panel III. In addition to descriptive statistics, gross and adjusted prevalence ratios were described. Results: MS was found in 100 (35.2%) individuals, 116 (40.9%) were obese and 165 (58.1%) had increased waist circumference. Polypharmacy was identified in 63 (22.3%) patients and 243 (85.9%) used antipsychotics. Under gross evaluation, women (PR = 1.88; 95%CI: 1.35-2.63) and those who used antidepressants (PR = 1.41; 95%CI: 1.05-1.88) showed an association with MS. After logistic regression, depression (PR = 1.86; 95%CI: 1.38-2.51), acanthosis (PR = 1.50; 95%CI: 1.18-1.90), use of antipsychotics (PR = 1.88; 95%CI: 1.13-2.75), and hypertriglyceridemic waist (PR = 3.33; 95%CI: 2.48-4.46) were associated with MS. Conclusion: The prevalence of MS signals multimorbidity among individuals with mental disorders and suggests a need for clinical screening.
C1 [Reis da Silva, Dandara Almeida; de Almeida, Ludmila Santana; Pimentel, Rodrigo Fernandes Weyll; Travassos, Ana Gabriela; Viana, Adriana Mattos; Cerqueira, Monique Magnavita Borba da Fonseca; de Souza, Marcio Costa; Barbosa, Paulo Jose Bastos; Cavalcante Neto, Jorge Lopes; Rossi, Thais Regis Aranha; Damasceno, Kairo Silvestre Meneses; das Merces, Magno Conceicao] Univ Estado Bahia UNEB, Dept Ciencias Vida, BR-41150000 Salvador, BA, Brazil.
   [Correa, Livia Lugarinho] Inst Estadual Diabet & Endocrinol Luiz Capriglion, BR-22451000 Rio De Janeiro, RJ, Brazil.
   [Pimentel, Rodrigo Fernandes Weyll; Cerqueira, Monique Magnavita Borba da Fonseca; D'Oliveira Junior, Argemiro; Damasceno, Kairo Silvestre Meneses; das Merces, Magno Conceicao] Univ Fed Bahia UFBA, Programa Posgrad Ciencias Saude, BR-40026010 Salvador, BA, Brazil.
   [Pimentel, Rodrigo Fernandes Weyll; Brandao, Tatiana Santos; Santana, Amalia Ivine Costa] Univ Fed Bahia, Hosp Univ Prof Edgard Santos HUPES UFBA, BR-40150000 Salvador, BA, Brazil.
   [Pimentel, Rodrigo Fernandes Weyll; Coelho, Julita Maria Freitas; Menezes, Amanda Cardoso; das Merces, Magno Conceicao] Ctr Univ UnidomPedro, BR-40010020 Salvador, BA, Brazil.
   [Gomes, Antonio Marcos Tosoli; Franca, Luiz Carlos Moraes; Brandao, Juliana de Lima; dos Santos, Livia Fajin de Mello; Gomes, Helena Ferraz; Peres, Ellen Marcia] Univ Estado Rio de Janeiro UERJ, Fac Enfermagem, BR-20551030 Rio De Janeiro, RJ, Brazil.
   [Travassos, Ana Gabriela] Secretaria Saude Estado Bahia, Ctr Especializado Diagnost Assistencia & Pesquisa, BR-40100160 Salvador, BA, Brazil.
   [de Sousa, Anderson Reis] Univ Fed Bahia UFBA, Escola Enfermagem, BR-40110060 Salvador, BA, Brazil.
   [Coelho, Julita Maria Freitas] Inst Fed Bahia IFBA, BR-43700000 Simoes Filho, BA, Brazil.
   [Magalhaes, Lucelia Batista Neves Cunha; das Merces, Millena Conceicao; das Merces, Magno Conceicao] Fac Tecnol & Ciencias UNIFTC, BR-41741590 Salvador, BA, Brazil.
   [Santos, Charles Souza] Univ Sudoeste Bahia UESB, BR-45200000 Jequie, BA, Brazil.
   [Fernandes, Sandra Lucia; Soriano, Eline de Almeida; Maduro, Isolda Prado de Negreiros Nogueira] Assoc Brasileira Nutrol ABRAN, BR-15801150 Catanduva, SP, Brazil.
   [Menezes, Amanda Cardoso] Hosp Ana Nery HAN, BR-40301155 Salvador, BA, Brazil.
C3 Universidade do Estado Bahia; Universidade Federal da Bahia;
   Universidade do Estado do Rio de Janeiro; Instituto Federal da Bahia
   (IFBA); Universidade Estadual do Sudoeste da Bahia
RP da Silva, DAR; das Merces, MC (corresponding author), Univ Estado Bahia UNEB, Dept Ciencias Vida, BR-41150000 Salvador, BA, Brazil.; das Merces, MC (corresponding author), Univ Fed Bahia UFBA, Programa Posgrad Ciencias Saude, BR-40026010 Salvador, BA, Brazil.; das Merces, MC (corresponding author), Ctr Univ UnidomPedro, BR-40010020 Salvador, BA, Brazil.; das Merces, MC (corresponding author), Fac Tecnol & Ciencias UNIFTC, BR-41741590 Salvador, BA, Brazil.
EM darsilva@uneb.br; magnomerces@hotmail.com
RI Cavalcante Neto, Jorge/R-9699-2016; Viana, Adriana/KIE-6292-2024;
   Brandao, Tatiana/KIA-8022-2024; França, Luiz/AFJ-8616-2022; Gomes,
   A./Q-6844-2016; MAGALHÃES, LUCELIA/AAA-1378-2019; Merces,
   Magno/S-6649-2017; Cerqueira, Monique/HKV-5843-2023; de Sousa,
   Anderson/AAU-7163-2021; Travassos, Ana Gabriela/E-6809-2016; Costa de
   Souza, Marcio/Y-8859-2018
OI MORAES FRANCA, LUIZ CARLOS/0000-0002-6370-115X; Silvestre Meneses
   Damasceno, Kairo/0000-0002-2444-4496; Travassos, Ana
   Gabriela/0000-0001-9242-828X; Almeida Reis da Silva,
   Dandara/0000-0001-6091-4080; Costa de Souza, Marcio/0000-0002-4922-6786;
   Santos, Charles Souza/0000-0001-5071-0359; Merces, Magno Conceicao
   das/0000-0003-3493-8606; Coelho, Julita/0000-0002-9520-5177; REIS DE
   SOUSA, ANDERSON/0000-0001-8534-1960; Pimentel, Rodrigo Fernandes
   Weyll/0000-0003-0101-0190
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NR 41
TC 1
Z9 1
U1 0
U2 1
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD AUG
PY 2022
VL 19
IS 16
AR 10203
DI 10.3390/ijerph191610203
PG 13
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA 4C9AZ
UT WOS:000846737800001
PM 36011835
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Martín-Cordero, L
   García, JJ
   Hinchado, MD
   Ortega, E
AF Martin-Cordero, Leticia
   Garcia, Juan J.
   Hinchado, Maria D.
   Ortega, Eduardo
TI The interleukin-6 and noradrenaline mediated inflammation-stress
   feedback mechanism is dysregulated in metabolic syndrome: Effect of
   exercise
SO CARDIOVASCULAR DIABETOLOGY
LA English
DT Article
ID ADIPOSE-TISSUE; PHAGOCYTIC PROCESS; PHYSICAL-ACTIVITY; ZUCKER RAT;
   SYNDROME-X; IN-VIVO; OBESITY; ALPHA; IL-6; MACROPHAGES
AB Background: Metabolic syndrome (MS) is a metabolic disorder associated with obesity, type-II diabetes, and "low grade inflammation", with the concomitant increased risk of cardiovascular events. Removal of the inflammatory mediator signals is a promising strategy to protect against insulin resistance, obesity, and other problems associated with MS such as cardiovascular disease. The aim of the present investigation was to determine the "inflammatory and stress status" in an experimental model of MS, and to evaluate the effect of a program of habitual exercise and the resulting training-induced adaptation to the effects of a single bout of acute exercise.
   Methods: Obese Zucker rats (fa/fa) were used as the experimental model of MS, and lean Zucker rats (Fa/fa) were used for reference values. The habitual exercise (performed by the obese rats) consisted of treadmill running: 5 days/week for 14 weeks, at 35 cm/s for 35 min in the last month. The acute exercise consisted of a single session of 25-35 min at 35 cm/s. Circulating concentrations of IL-6 (a cytokine that regulates the inflammatory and metabolic responses), CRP (a systemic inflammatory marker), and corticosterone (CTC) (the main glucocorticoid in rats) were determined by ELISA, and that of noradrenaline (NA) was determined by HPLC. Glucose was determined by standard methods.
   Results: The genetically obese animals showed higher circulating levels of glucose, IL-6, PCR, and NA compared with the control lean animals. The habitual exercise program increased the concentration of IL-6, PCR, NA, and glucose, but decreased that of CTC. Acute exercise increased IL-6, CRP, and NA in the sedentary obese animals, but not in the trained obese animals. CTC was increased after the acute exercise in the trained animals only.
   Conclusion: Animals with MS present a dysregulation in the feedback mechanism between IL-6 and NA which can contribute to the systemic low-grade inflammation and/or hyperglycaemia of MS. An inappropriate exercise intensity can worsen this dysregulation, contributing to the metabolic, inflammatory, and stress disorders associated with MS. Habitual exercise (i.e., training) induces a positive adaptation in the response to acute exercise.
C1 [Martin-Cordero, Leticia; Garcia, Juan J.; Hinchado, Maria D.; Ortega, Eduardo] Univ Extremadura, Fac Ciencias, Dept Fisiol, Grp Invest Inmunofisiol, Badajoz, Spain.
C3 Universidad de Extremadura
RP Ortega, E (corresponding author), Univ Extremadura, Fac Ciencias, Dept Fisiol, Grp Invest Inmunofisiol, Badajoz, Spain.
EM orincon@unex.es
RI Garcia, Juan/C-7383-2013; Ortega, Eduardo/H-9891-2016; Martin-Cordero,
   Leticia/H-9711-2015
OI Garcia, Juan/0000-0002-8222-4213; Ortega, Eduardo/0000-0002-7007-7615;
   Martin-Cordero, Leticia/0000-0002-3651-2265; HINCHADO SANCHEZ-MORO,
   MARIA DOLORES/0000-0002-9709-4714
FU Ministry of Science and Innovation [DEP2006-56187-C04-03]; Junta de
   Extremadura [GRU10020]; FEDER; RETICEF; Fundacion Valhondo de
   Extremadura, Spain
FX This work was partially supported by grants from the Ministry of Science
   and Innovation (DEP2006-56187-C04-03), Junta de Extremadura (GRU10020),
   FEDER, RETICEF, and Fundacion Valhondo de Extremadura, Spain. We are
   grateful for the collaboration of specialized personnel of the animal
   facilities at the Faculty of Medicine of the Autonomous University of
   Madrid.
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NR 59
TC 54
Z9 61
U1 0
U2 3
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1475-2840
J9 CARDIOVASC DIABETOL
JI Cardiovasc. Diabetol.
PD MAY 20
PY 2011
VL 10
AR 42
DI 10.1186/1475-2840-10-42
PG 9
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism
GA 779QN
UT WOS:000291795300001
PM 21599899
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Newman, E
   O'Connor, DB
   Conner, M
AF Newman, Emily
   O'Connor, Daryl B.
   Conner, Mark
TI Daily hassles and eating behaviour: The role of cortisol reactivity
   status
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE stress; cortisol; hassles; snacking; obesity; mood; metabolic syndrome
ID PITUITARY-ADRENAL AXIS; DIETARY RESTRAINT; PERSONALITY-TRAITS; SALIVARY
   CORTISOL; STRESS RESPONSES; FOOD CHOICE; SHORT-FORM; ANXIETY;
   QUESTIONNAIRE; WOMEN
AB Previous research has shown high cortisol reactors to consume a greater amount of snack foods than tow reactors following a laboratory stressor. The current study tested whether high cortisol reactors also consume more snacks than tow reactors in response to field stressors. Fifty pre-menopausal women completed a laboratory stressor, provided saliva samples to assess cortisol reactor status and then completed daily hassles and snack intake diaries over the next fourteen days. Hierarchical multivariate linear modelling showed a significant association between daily hassles and snack intake within the overall sample, where an increased number of hassles was associated with increased snack intake. This significant positive association between number of hassles and snack intake was only observed within the high cortisol reactors and not within the low cortisol reactors. These findings suggest that high cortisol reactivity to stress promotes food intake. Furthermore, the eating style variables of restraint, emotional eating, external eating and disinhibition were more strongly associated with snack intake in high reactors than in low reactors. This suggests that cortisol. reactivity may in part account for the moderating role of eating style on stress-induced eating. The results are discussed within the context of future health risk. (c) 2006 Elsevier Ltd. All rights reserved.
C1 Univ Leeds, Inst Psychol Sci, Leeds LS2 9JT, W Yorkshire, England.
C3 University of Leeds
RP Newman, E (corresponding author), Univ Edinburgh, Sch Hlth Social Sci, Old Med Sch, Teviot Pl, Edinburgh EH8 9AG, Midlothian, Scotland.
EM emily.newman@ed.ac.uk
RI Conner, Mark/N-9063-2013
OI O'Connor, Daryl/0000-0003-4117-4093; Newman, Emily/0000-0003-2601-6863;
   Conner, Mark/0000-0002-6229-8143
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NR 44
TC 218
Z9 264
U1 0
U2 40
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD FEB
PY 2007
VL 32
IS 2
BP 125
EP 132
DI 10.1016/j.psyneuen.2006.11.006
PG 8
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA 147FE
UT WOS:000244988000005
PM 17198744
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Yilmaz, A
   Sechtem, U
AF Yilmaz, Ali
   Sechtem, Udo
TI Angina pectoris in patients with normal coronary angiograms: current
   pathophysiological concepts and therapeutic options
SO HEART
LA English
DT Article
ID CARDIOVASCULAR MAGNETIC-RESONANCE; CARDIAC SYNDROME-X; ARTERY-DISEASE;
   MICROVASCULAR DYSFUNCTION; CHEST-PAIN; PERFUSION; STRESS; HEART
C1 [Yilmaz, Ali; Sechtem, Udo] Robert Bosch Krankenhaus, Div Cardiol, D-70376 Stuttgart, Germany.
C3 Bosch; Robert Bosch Krankenhaus
RP Yilmaz, A (corresponding author), Robert Bosch Krankenhaus, Div Cardiol, Auerbachstr 110, D-70376 Stuttgart, Germany.
EM ali.yilmaz@rbk.de
RI Sechtem, Udo/ADK-6380-2022; Yılmaz, Ali/KLZ-9798-2024
FU Robert-Bosch-Foundation [I1]
FX AY is financially supported by a grant from the Robert-Bosch-Foundation
   (grant-ID I1).
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NR 20
TC 12
Z9 12
U1 0
U2 4
PU B M J PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 1355-6037
J9 HEART
JI Heart
PD JUL
PY 2012
VL 98
IS 13
BP 1020
EP 1029
DI 10.1136/heartjnl-2011-301352
PG 10
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 955ER
UT WOS:000305000400012
PM 22668869
DA 2025-06-11
ER

PT J
AU Neves, LM
   Silva-Batista, C
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   Mendes, SD
   Saad, F
   Codogno, JS
   Nunes, RH
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   Juday, V
   Lafer, B
   Ugrinowitsch, C
AF Neves, Lucas Melo
   Silva-Batista, Carla
   Marquesini, Raquel
   da Cunha, Telma Fatima
   Dimateo, Elisa
   Nascimento, Luciana
   Moreira-Neto, Acacio
   de Lima Miliatto, Angelo Correa
   Mendes, Sheila das Chagas
   Saad, Flavia
   Codogno, Jamile Sanches
   Nunes, Renato Hoffmann
   Ritti-Dias, Raphael Mendes
   Juday, Valeria
   Lafer, Beny
   Ugrinowitsch, Carlos
TI Aerobic exercise program with or without motor complexity as an add-on
   to the pharmacological treatment of depression - study protocol for a
   randomized controlled trial
SO TRIALS
LA English
DT Article
DE Depression; Cognitive function; Neuroplasticity; Brain volume;
   Cardiovascular; Metabolic syndrome; Coordinative exercise; Clinical
   trial; Physical activity level
ID BIPOLAR DISORDER; BIOLOGICAL RHYTHMS; PERCEIVED EXERTION; COGNITIVE
   FUNCTION; ANXIETY; SYMPTOMS; SLEEP; HEART; HYPERTENSION; SUICIDE
AB BackgroundPatients with major depression disorder presents increased rates of cognitive decline, reduced hippocampal volume, poor sleep quality, hypertension, obesity, suicidal ideation and behavior, and decreased functionality. Although continuous aerobic exercise (CAE) improves some of the aforementioned symptoms, comorbidities, and conditions, recent studies have suggested that performing aerobic exercise with motor complexity (AEMC) may be more beneficial for cognitive decline, hippocampal volume, and functionality. Therefore, this randomized controlled trial will compare the effects of CAE and AEMC on depression score, cognitive function, hippocampal volume, brain-derived neurotrophic factor expression, sleep parameters, cardiovascular risk parameters, suicidal behavior, functionality, and treatment costs in patients with depression.Methods/designSeventy-five medicated patients with depression will be recruited from a Basic Healthcare Unit to participate in this prospective, parallel group, single blinded, superiority, randomized controlled trial. Patients with depression according to DSM-V criteria will be balanced and randomly assigned (based on depression scores and number of depressive episodes) to a non-exercising control (C), CAE, and AEMC groups. The CAE and AEMC groups will exercise for 60min, twice a week for 24weeks (on non-consecutive days). Exercise intensity will be maintained between 12 and 14 points of the rating of perceived exertion scale (similar to 70-80% of the maximum heart rate). The CAE group will perform a continuous aerobic exercise while the AEMC group will perform exercises with progressively increased motor complexity. Blinded raters will assess patients before and after the intervention period. The primary outcome measure will be the change in depression score measured by the Montgomery-Asberg Depression Rating Scale. Secondary outcomes will include measures of cognitive function, hippocampal volume, brain-derived neurotrophic factor expression, sleep parameters, cardiovascular risk parameters, suicidal behavior, functionality, and treatment costs.DiscussionThis study was selected in the call of public policy programs for the Brazilian Unified National Health System - PPSUS 2015. To our knowledge, this is the first pragmatic trial to test the effect of adding AEMC to the pharmacological treatment of patients with depression and to evaluate the possible reductions in depression symptoms and healthcare costs.Trial registrationBrazilian Clinical Trials Registry (ReBec) - RBR-9zgxzd - Registered on4 Jan. 2017.
C1 [Neves, Lucas Melo; Silva-Batista, Carla; Marquesini, Raquel; da Cunha, Telma Fatima; Dimateo, Elisa; Nascimento, Luciana; Moreira-Neto, Acacio; de Lima Miliatto, Angelo Correa; Ugrinowitsch, Carlos] Univ Sao Paulo EEFE USP, Sch Phys Educ & Sport, Sao Paulo, Brazil.
   [Mendes, Sheila das Chagas] Univ Paulista UNIP, Sao Paulo, Brazil.
   [Saad, Flavia] Fed Univ Sao Paulo UNIFESP, Sao Paulo, Brazil.
   [Codogno, Jamile Sanches] Sao State Univ UNESP, Presidente Prudente, Brazil.
   [Nunes, Renato Hoffmann] DASA, Sao Paulo, Brazil.
   [Nunes, Renato Hoffmann] Fac Med Sci Santa Casa Sao Paulo, Sao Paulo, Brazil.
   [Ritti-Dias, Raphael Mendes] Univ Nove Julho, Sao Paulo, Brazil.
   [Juday, Valeria] Anhembi Morumbi Univ UAM, Sao Paulo, Brazil.
   [Lafer, Beny] Univ Sao Paulo IPq USP, Dept Psyquiatr, Sao Paulo, Brazil.
C3 Universidade Paulista; Universidade Federal de Sao Paulo (UNIFESP);
   Universidade Nove de Julho
RP Ugrinowitsch, C (corresponding author), Univ Sao Paulo EEFE USP, Sch Phys Educ & Sport, Sao Paulo, Brazil.
EM ugrinowi@usp.br
RI Ugrinowitsch, Carlos/A-3925-2010; Nunes, Renato/L-8298-2013; Cunha,
   Telma/I-5222-2016; Lafer, Beny/F-9390-2015; Codogno,
   Jamile/AAK-9584-2021; Silva-Batista, Carla/P-3334-2018; Melo Neves,
   Lucas/K-6050-2016; Lafer, Beny/C-1055-2012; Ritti-Dias,
   Raphael/G-4200-2013
OI Silva-Batista, Carla/0000-0003-0244-6535; Melo Neves,
   Lucas/0000-0003-2426-9736; Lafer, Beny/0000-0002-6132-9999; da Cunha,
   Telma Fatima/0000-0001-7542-093X; Ritti-Dias,
   Raphael/0000-0001-7883-6746; Moreira, Acacio/0000-0002-1477-5849
FU Fundacao de Amparo a Pesquisa do Estado de Sao Paulo [FAPESP -
   2016/15210/9]; Coordenacao de Aperfeicoamento de Pessoal de Nivel
   Superior [CAPES - PGPTA59/2014]; CAPES-PROEX; CAPES - Codigo de
   Financiamento 001; Conselho Nacional de Desenvolvimento Cientifico e
   Tecnologico [CNPq - 303085/2015-0]
FX PThe study will be supported by a grant from the Fundacao de Amparo a
   Pesquisa do Estado de Sao Paulo (FAPESP - 2016/15210/9), Coordenacao de
   Aperfeicoamento de Pessoal de Nivel Superior (CAPES - PGPTA59/2014),
   CAPES-PROEX, CAPES - Codigo de Financiamento 001, and Conselho Nacional
   de Desenvolvimento Cientifico e Tecnologico (CNPq - 303085/2015-0).
   Sponsor and funders of this study do not have influence or authority
   regarding collection, management, analysis, and interpretation of data,
   writing of the report, or the decision to submit the report for
   publication.
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NR 90
TC 1
Z9 1
U1 1
U2 24
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1745-6215
J9 TRIALS
JI Trials
PD OCT 10
PY 2018
VL 19
AR 545
DI 10.1186/s13063-018-2906-y
PG 14
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Research & Experimental Medicine
GA GW9DH
UT WOS:000447281600004
PM 30305151
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Lucini, D
   Solaro, N
   Lesma, A
   Gillet, VB
   Pagani, M
AF Lucini, Daniela
   Solaro, Nadia
   Lesma, Alessandro
   Gillet, Veronique Bernadette
   Pagani, Massimo
TI Health Promotion in the Workplace: Assessing Stress and Lifestyle With
   an Intranet Tool
SO JOURNAL OF MEDICAL INTERNET RESEARCH
LA English
DT Article
DE Stress; lifestyle; risk factor; prevention; web-based questionnaire
ID AMERICAN-HEART-ASSOCIATION; METABOLIC SYNDROME; PHYSICAL-ACTIVITY;
   CARDIOVASCULAR-DISEASE; RISK-FACTORS; MYOCARDIAL-INFARCTION;
   NATIONAL-HEART; PRIMARY-CARE; 52 COUNTRIES; MANAGEMENT
AB Background: Chronic noncommunicable conditions, particularly cardiovascular and metabolic diseases, are the major causes of death and morbidity in both industrialized and low- to middle-income countries. Recent epidemiological investigations suggest that management of lifestyle factors, such as stress and lack of physical activity, could have an important value in cardiometabolic conditions, while information technology tools could play a significant facilitatory role.
   Objectives: The objective of our study was to verify the feasibility of using a private website, directed to the workers of a major Italian company, to describe their health profile and lifestyle and work habits using an ad hoc self-administered questionnaire.
   Methods: We administered anonymous multiple choice Web-based questionnaires to 945 participants (683 completed the task) as part of an ongoing health promotion program in a multinational company. Qualitative and quantitative data were synthesized with nonlinear principal component analysis to construct indicators (ie, variables) for stress, control, and lifestyle domains. Considering in addition absenteeism, the Calinski-Harabasz statistic and cluster analysis jointly differentiated seven clusters, which displayed different distributions of standardized classification variables. The final step consisted in assessing the relationship of the resulting seven subject typologies with personal data, illnesses, and metabolic syndrome status, carried out for the most part with descriptive methods.
   Results: Statistical analyses singled out two not-overlapping domains of stress and control, as well as three not-overlapping domains of physical activity, smoking, and alcohol habits. The centroids of the seven clusters generated by the procedure were significantly (P < .001) different considering all possible 21 comparisons between couples of groups. Percentage distributions of variables describing personal information (gender, age group, work category, illness status, or metabolic syndrome) within participant typologies show some noteworthy findings: females, workers aged 35-44 years, junior white collar workers, and respondents reporting illness were more prevalent in the stress group than in the overall studied population; preclinical metabolic syndrome status was more prevalent in the group with higher alcohol consumption. Absentees reported more illness.
   Conclusions: The present Intranet-based study shows the potential of applying diverse statistical techniques to deal jointly with qualitative and quantitative self-reported data. The resulting formal description of subject typologies and their relationship with personal characteristics might provide a convenient tool for supporting health promotion in the work environment.
C1 [Lucini, Daniela; Pagani, Massimo] Univ Milan, Dipartimento Sci Clin, Ctr Ric Terapia Neurovegetat & Med Esercizio, I-20157 Milan, Italy.
   [Solaro, Nadia] Univ Milano Bicocca, Dipartimento Stat, Milan, Italy.
   [Lesma, Alessandro; Gillet, Veronique Bernadette] ENI Corp, Milan, Italy.
   [Pagani, Massimo] Osped L Sacco, UO Telemed & Med Sport, Milan, Italy.
C3 University of Milan; University of Milano-Bicocca; Eni SpA; University
   of Milan; Luigi Sacco Hospital
RP Lucini, D (corresponding author), Univ Milan, Dipartimento Sci Clin, Ctr Ric Terapia Neurovegetat & Med Esercizio, Via G B Grassi 74, I-20157 Milan, Italy.
EM daniela.lucini@ctnv.unimi.it
RI Lucini, Daniela/ABD-7517-2021
OI Lucini, Daniela/0000-0003-4845-8988; SOLARO, NADIA/0000-0001-8732-5737
FU ASI [PRIN 2007]
FX We would like to acknowledge the expert secretarial help of Giovanna
   Maccio'. Supported by ASI contract DCMC, PRIN 2007.
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NR 50
TC 24
Z9 26
U1 0
U2 23
PU JMIR PUBLICATIONS, INC
PI TORONTO
PA 59 WINNERS CIRCLE, TORONTO, ON M4L 3Y7, CANADA
SN 1438-8871
J9 J MED INTERNET RES
JI J. Med. Internet Res.
PD OCT-DEC
PY 2011
VL 13
IS 4
AR e88
DI 10.2196/jmir.1798
PG 21
WC Health Care Sciences & Services; Medical Informatics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services; Medical Informatics
GA 879EU
UT WOS:000299313300015
PM 22068357
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Silverstein, RL
AF Silverstein, Roy L.
TI Type 2 scavenger receptor CD36 in platelet activation: the role of
   hyperlipemia and oxidative stress
SO CLINICAL LIPIDOLOGY
LA English
DT Review
DE CD36; microparticles; oxidized LDL; platelets; thrombosis
ID LOW-DENSITY-LIPOPROTEIN; FOAM CELL-FORMATION; CHAIN FATTY-ACIDS;
   HUMAN-BLOOD-PLATELETS; ATHEROSCLEROTIC LESION DEVELOPMENT;
   INSULIN-RESISTANCE SYNDROME; RETINAL-PIGMENT EPITHELIUM; FUSION PROTEINS
   DEFINE; E-DEFICIENT MICE; ENDOTHELIAL MICROPARTICLES
AB Platelet hyper-reactivity and a systemic prothrombotic state are associated with atherosclerosis and other inflammatory conditions. CD36, a member of the Type 2 scavenger receptor family, is a multiligand pattern recognition receptor that recognizes specific oxidized phospholipids, molecules expressed on microbial pathogens, apoptotic cells, and cell-derived microparticles. Recent studies have demonstrated that CD36 binding to oxidized LDL or microparticles activates a specific signaling pathway that induces platelet activation. This pathway is activated in vivo in the setting of hyperlipidemia and oxidant stress. Genetic deletion of CD36 protects mice from pathological thrombosis associated with hyperlipidemia without any apparent effect on normal hemostasis. Targeting CD36 or its signaling pathway could potentially lead to the development of novel antithrombotic therapies for patients with atheroinflammatory disorders.
C1 Case Western Reserve Univ, Lerner Coll Med, Cleveland Clin,Dept Cell Biol, Dept Mol Med,Cleveland Clin Fdn,Lerner Res Inst, Cleveland, OH 44106 USA.
C3 Cleveland Clinic Foundation; University System of Ohio; Case Western
   Reserve University
RP Silverstein, RL (corresponding author), Case Western Reserve Univ, Lerner Coll Med, Cleveland Clin,Dept Cell Biol, Dept Mol Med,Cleveland Clin Fdn,Lerner Res Inst, 9500 Euclid Ave 44195, Cleveland, OH 44106 USA.
EM silverr2@ccf.org
FU National Institute of Health [NIH P50 HL81011, NIH P01 HL087018]
FX Roy L Silverstein receives financial support from the National Institute
   of Health (grants NIH P50 HL81011 and NIH P01 HL087018). The author has
   no relevant affiliations or financial involvement with any organization
   or entity with a financial interest in or financial conflict with the
   subject matter or materials discussed in the manuscript. This includes
   employment, consultancies, honoraria, stock ownership or options, expert
   testimony, grants or patents received or pending, or royalties. No
   writing assistance was utilized in the production of this manuscript.
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NR 149
TC 27
Z9 31
U1 1
U2 13
PU FUTURE MEDICINE LTD
PI LONDON
PA UNITEC HOUSE, 3RD FLOOR, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON, N3
   1QB, ENGLAND
SN 1758-4299
EI 1758-4302
J9 CLIN LIPIDOL
JI Clin. Lipidol.
PD DEC
PY 2009
VL 4
IS 6
BP 767
EP 779
DI 10.2217/CLP.09.57
PG 13
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 532XA
UT WOS:000272782500014
PM 20161667
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Simmons, RA
AF Simmons, RA
TI Developmental origins of diabetes: The role of oxidative stress
SO FREE RADICAL BIOLOGY AND MEDICINE
LA English
DT Review
DE intrauterine growth retardation; type 2 diabetes; Barker hypothesis;
   fetal origins of adult disease; free radical
ID INTRAUTERINE GROWTH-RETARDATION; PANCREATIC BETA-CELL; LOW-BIRTH-WEIGHT;
   SIGNALING PROTEIN EXPRESSION; THRIFTY PHENOTYPE HYPOTHESIS;
   INSULIN-RESISTANCE SYNDROME; IMPAIRED GLUCOSE-TOLERANCE;
   FOR-GESTATIONAL-AGE; FETAL-GROWTH; GENE-EXPRESSION
AB The "thrifty phenotype" hypothesis proposes that the fetus adapts to all adverse intrauterine Milieu by optimizing the use of a reduced nutrient supply to ensure Survival, but, by favoring the development of certain organs over that of others, this leads to persistent alterations in the growth and function of developing tissues. This concept has been somewhat controversial; however, recent epidemiological, clinical, and animal studies provide support for the developmental origins of disease hypothesis. Underlying mechanisms include reprogramming of the hypothalamic-pituitary-adrenal axis, islet development, and insulin signaling pathways. Emerging data suggest that oxidative stress and mitochondrial dysfunction may also play critical roles in the pathogenesis of type 2 diabetes in individuals who were growth retarded at birth. (C) 2006 Elsevier Inc. All rights reserved.
C1 Childrens Hosp Philadelphia, Dept Pediat, Philadelphia, PA 19104 USA.
   Univ Penn, Philadelphia, PA 19104 USA.
C3 University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of
   Philadelphia; University of Pennsylvania
RP Childrens Hosp Philadelphia, Dept Pediat, Philadelphia, PA 19104 USA.
EM rsimmons@mail.med.upenn.edu
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NR 93
TC 107
Z9 128
U1 1
U2 2
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0891-5849
EI 1873-4596
J9 FREE RADICAL BIO MED
JI Free Radic. Biol. Med.
PD MAR 15
PY 2006
VL 40
IS 6
BP 917
EP 922
DI 10.1016/j.freeradbiomed.2005.12.018
PG 6
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 027GX
UT WOS:000236404100001
PM 16540386
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Assies, J
   Lok, A
   Bockting, CL
   Weverling, GJ
   Lieverse, R
   Visser, I
   Abeling, NGGM
   Duran, M
   Schene, AH
AF Assies, J
   Lok, A
   Bockting, CL
   Weverling, GJ
   Lieverse, R
   Visser, I
   Abeling, NGGM
   Duran, M
   Schene, AH
TI Fatty acids and homocysteine levels in patients with recurrent
   depression: an explorative pilot study
SO PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
LA English
DT Article; Proceedings Paper
CT 1st Brain Phospholipids Conference
CY AUG-SEP -, 2003
CL Aviemore, SCOTLAND
ID BLOOD-CELL MEMBRANES; LIPID-PEROXIDATION; ERYTHROCYTE-MEMBRANES; PLASMA
   HOMOCYSTEINE; CHOLESTERYL ESTERS; MAJOR DEPRESSION; DISEASE;
   OMEGA-3-FATTY-ACIDS; FOLATE; PHOSPHOLIPIDS
AB Major depressive disorders (MDD) and cardiovascular disease are mutually associated. They share signs and symptoms of the "metabolic syndrome". Two observations that may be causally related with the metabolic syndrome and therefore with both MDD and cardiovascular disease are a decrease in omega-3 polyunsaturated fatty acids (PUFAs) and a rise in plasma homocysteine (tHcy) levels. Both the rise in tHcy and the decrease in omega-3 PUFAs may be associated with enhanced lipid peroxidation.
   We exploratively studied 44 randomly chosen patients out of a cohort of 134 patients with the recurrent form of MDD (MDD-R). We measured tHcy levels together with saturated FAs, monounsaturated fatty acids (MUFAs) and PUFAs of the omega-3, omega-6 and omega-9 series in plasma and erythrocytes. Levels were compared with laboratory reference values. The main findings were a decrease in the erythrocytes of C22:5omega-3, C22:6omega-3, C24:1omega-9 and C20:3omega-9 and in the plasma a decrease in C24:1omega-9 and C20:3omega-9. The only significant association we found was between the total of omega-6 fatty acids and plasma tHcy. The FA alterations were found in patients although most of them were clinically recovered, suggesting that the alterations may represent a biological" trait" marker for recurrent depression. (C) 2004 Elsevier Ltd. All rights reserved.
C1 Univ Amsterdam, Acad Med Ctr, Dept Psychiat, NL-1105 BC Amsterdam, Netherlands.
   Univ Amsterdam, Acad Med Ctr, Dept Clin Epidemiol & Biostat, NL-1105 AZ Amsterdam, Netherlands.
   GGZ Buitenamstel, Dept Psychiat, Amsterdam, Netherlands.
   Univ Amsterdam, Acad Med Ctr, Netherlands Ctr Occupat Dis, Coronel Inst Occupat & Environ Hlth, NL-1105 AZ Amsterdam, Netherlands.
   Univ Amsterdam, Acad Med Ctr, Lab Genet Metab Dis, NL-1105 AZ Amsterdam, Netherlands.
C3 University of Amsterdam; Academic Medical Center Amsterdam; University
   of Amsterdam; Academic Medical Center Amsterdam; University of
   Amsterdam; Academic Medical Center Amsterdam; University of Amsterdam;
   Academic Medical Center Amsterdam
RP Univ Amsterdam, Acad Med Ctr, Dept Psychiat, Tafelbergweg 25, NL-1105 BC Amsterdam, Netherlands.
EM j.assies@amc.uva.nl
RI Schene, A.H./H-8085-2014; Bockting, Claudi/K-3768-2019
OI Bockting, Claudi L.H./0000-0002-9220-9244
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NR 43
TC 47
Z9 54
U1 0
U2 6
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0952-3278
EI 1532-2823
J9 PROSTAG LEUKOTR ESS
JI Prostaglandins Leukot. Essent. Fatty Acids
PD APR
PY 2004
VL 70
IS 4
BP 349
EP 356
DI 10.1016/j.plefa.2003.12.009
PG 8
WC Biochemistry & Molecular Biology; Cell Biology; Endocrinology &
   Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Biochemistry & Molecular Biology; Cell Biology; Endocrinology &
   Metabolism
GA 809GE
UT WOS:000220624400004
PM 15041026
DA 2025-06-11
ER

PT J
AU Meza-Miranda, ER
   Camargo, A
   Rangel-Zuñiga, OA
   Delgado-Lista, J
   Garcia-Rios, A
   Perez-Martinez, P
   Tasset-Cuevas, I
   Tunez, I
   Tinahones, FJ
   Perez-Jimenez, F
   Lopez-Miranda, J
AF Romina Meza-Miranda, Eliana
   Camargo, Antonio
   Alberto Rangel-Zuniga, Oriol
   Delgado-Lista, Javier
   Garcia-Rios, Antonio
   Perez-Martinez, Pablo
   Tasset-Cuevas, Inma
   Tunez, Isaac
   Tinahones, Francisco J.
   Perez-Jimenez, Francisco
   Lopez-Miranda, Jose
TI Postprandial oxidative stress is modulated by dietary fat in adipose
   tissue from elderly people
SO AGE
LA English
DT Article
DE Oxidative stress; Postprandial state; Aging; Dietary fat; Metabolic
   syndrome
ID METABOLIC SYNDROME; ENDOTHELIAL DYSFUNCTION; EXERCISE INTERVENTION; AGE;
   HYPERTENSION; AVAILABILITY; INFLAMMATION; GLUTATHIONE; PREVALENCE;
   ACTIVATION
AB We have investigated whether dietary fat modifies the postprandial oxidative stress in adipose tissue of elderly people. Twenty participants received three diets for 4 weeks each: SFA-rich diet, Mediterranean (Med) diet enriched in MUFA with virgin olive oil, and a low-fat, high-carbohydrate diet enriched in n-3 PUFA (alpha-linolenic acid from plant origin) (CHO-PUFA diet). After 12 h of fasting, volunteers received a breakfast reflecting the fatty acid composition of the diet ingested in the preceding dietary period. Med diet induced higher postprandial SOD2 and TrxR mRNA levels, and CHO-PUFA diet induced higher GPx1 and TrxR mRNA levels compared with SFA-rich diet. Med and CHO-PUFA breakfasts induced a postprandial increase in plasma reduced glutathione (GSH), and a greater postprandial GSH/oxidized glutathione ratio compared to the SFA-rich diet. Our study suggests that the consumption of Med and CHO-PUFA diets may reduce postprandial oxidative stress compared to an SFA-rich diet, which may be due to higher antioxidant enzymes gene expression in adipose tissue.
C1 [Romina Meza-Miranda, Eliana; Camargo, Antonio; Alberto Rangel-Zuniga, Oriol; Delgado-Lista, Javier; Garcia-Rios, Antonio; Perez-Martinez, Pablo; Perez-Jimenez, Francisco; Lopez-Miranda, Jose] Univ Cordoba, Reina Sofia Univ Hosp, IMIBIC, Lipids & Atherosclerosis Res Unit, Avda Menendez Pidal S-N, E-14004 Cordoba, Spain.
   [Romina Meza-Miranda, Eliana; Camargo, Antonio; Alberto Rangel-Zuniga, Oriol; Delgado-Lista, Javier; Garcia-Rios, Antonio; Perez-Martinez, Pablo; Tinahones, Francisco J.; Perez-Jimenez, Francisco; Lopez-Miranda, Jose] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr CIBEROBN, Madrid, Spain.
   [Tasset-Cuevas, Inma; Tunez, Isaac] Univ Cordoba, Hosp Univ Reina Sofia, IMIBIC, Dept Biochem & Mol Biol,Fac Med, E-14004 Cordoba, Spain.
   [Tinahones, Francisco J.] Hosp Virgen de la Victoria, Malaga, Spain.
C3 Universidad de Cordoba; CIBER - Centro de Investigacion Biomedica en
   Red; CIBEROBN; Instituto de Salud Carlos III; Universidad de Cordoba;
   Hospital Virgen de la Victoria
RP Lopez-Miranda, J (corresponding author), Univ Cordoba, Reina Sofia Univ Hosp, IMIBIC, Lipids & Atherosclerosis Res Unit, Avda Menendez Pidal S-N, E-14004 Cordoba, Spain.
EM jlopezmir@uco.es
RI Delgado-Lista, Javier/KAM-7412-2024; Lopez-Miranda, Jose/Y-8306-2019;
   Tinahones, Francisco/AAB-2882-2020; Tejada, Silvia/L-7297-2014; Jimenez,
   Francisco/AAJ-9559-2021; Perez Martinez, Pablo/AEL-6176-2022; Camargo
   Garcia, Antonio/G-9720-2015
OI Perez Martinez, Pablo/0000-0001-7716-8117; Tinahones, Francisco
   J/0000-0001-6871-4403; Perez Jimenez, Francisco/0000-0001-9808-1280;
   Lopez-Miranda, Jose/0000-0002-8844-0718; Camargo Garcia,
   Antonio/0000-0002-0415-4184; Meza Miranda, Eliana
   Romina/0000-0001-9791-8835; Rangel-Zuniga, Oriol
   Alberto/0000-0003-3495-5705; Perez-Jimenez,
   Francisco/0000-0001-7499-7681; Delgado Lista, Francisco
   Javier/0000-0002-2982-2716
FU Spanish Ministry of Science and Innovation [AGL2004-07907,
   AGL2006-01979, AGL2009-12270, SAF07-62005, PI10/02412, FIS PI10/01041];
   Consejeria de Economia, Innovacion y Ciencia, Proyectos de Investigacion
   de Excelencia, Junta de Andalucia [P06-CTS-01425, CTS5015, AGR922];
   Consejeria de Salud, Junta de Andalucia [06/128, 07/43, PI0193/09,
   06/129, 0118/08, PI-0252/09, PI-0058/10]; Fondo Europeo de Desarrollo
   Regional
FX The CIBEROBN is an initiative of the Instituto de Salud Carlos III,
   Madrid, Spain. We thank Maria Jose Gomez-Luna for technical support.
   This study was supported in part by research grants from the Spanish
   Ministry of Science and Innovation (AGL2004-07907, AGL2006-01979, and
   AGL2009-12270 to J L-M; SAF07-62005 and PI10/02412 to F P-J; and FIS
   PI10/01041 to P P-M); Consejeria de Economia, Innovacion y Ciencia,
   Proyectos de Investigacion de Excelencia, Junta de Andalucia
   (P06-CTS-01425 to J L-M; CTS5015 and AGR922 to F P-J); Consejeria de
   Salud, Junta de Andalucia (06/128, 07/43, and PI0193/09 to J L-M; 06/129
   to F P-J; 0118/08 to F F-J; PI-0252/09 to J D-L; and PI-0058/10 to P
   P-M); Fondo Europeo de Desarrollo Regional.
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NR 54
TC 10
Z9 11
U1 0
U2 16
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0161-9152
EI 1574-4647
J9 AGE
JI Age
PD APR
PY 2014
VL 36
IS 2
BP 507
EP 517
DI 10.1007/s11357-013-9579-y
PG 11
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA AD2FG
UT WOS:000333048600001
PM 23963800
OA Green Published
DA 2025-06-11
ER

PT J
AU Dunn, J
   Runge, R
   Snyder, M
AF Dunn, Jessilyn
   Runge, Ryan
   Snyder, Michael
TI Wearables and the medical revolution
SO PERSONALIZED MEDICINE
LA English
DT Review
DE digital health; longitudinal monitoring; sensors; wearables; wireless
   telemetry
ID GASTRIC MYOELECTRIC ACTIVITY; ATRIAL-FIBRILLATION; METABOLIC SYNDROME;
   WRIST-WORN; HEART-RATE; SENSOR; SYSTEM; BIOSENSOR; DEVICES; SLEEP
AB Wearable sensors are already impacting healthcare and medicine by enabling health monitoring outside of the clinic and prediction of health events. This paper reviews current and prospective wearable technologies and their progress toward clinical application. We describe technologies underlying common, commercially available wearable sensors and early-stage devices and outline research, when available, to support the use of these devices in healthcare. We cover applications in the following health areas: metabolic, cardiovascular and gastrointestinal monitoring; sleep, neurology, movement disorders and mental health; maternal, pre-and neo-natal care; and pulmonary health and environmental exposures. Finally, we discuss challenges associated with the adoption of wearable sensors in the current healthcare ecosystem and discuss areas for future research and development.
C1 [Dunn, Jessilyn; Runge, Ryan; Snyder, Michael] Stanford Univ, Dept Genet, Stanford, CA 94305 USA.
   [Dunn, Jessilyn; Runge, Ryan] Stanford Univ, Dept Bioengn, Stanford, CA 94305 USA.
   [Dunn, Jessilyn; Runge, Ryan] Stanford Univ, Mobilize Ctr, Stanford, CA 94305 USA.
C3 Stanford University; Stanford University; Stanford University
RP Snyder, M (corresponding author), Stanford Univ, Dept Genet, Stanford, CA 94305 USA.
EM mpsnyder@stanford.edu
OI Dunn, Jessilyn/0000-0002-3241-8183; Snyder, Michael/0000-0003-0784-7987
FU Mobilize Center, a NIH Big Data to Knowledge Center of Excellence [NIH
   U54 EB020405]
FX J Dunn and R Runge are funded by the Mobilize Center, a NIH Big Data to
   Knowledge Center of Excellence (NIH U54 EB020405). M Snyder is a
   cofounder of Personalis, Qbio, Sensomics and January. He is on the
   scientific advisory of these companies and Genapsys. The authors have no
   other relevant affiliations or financial involvement with any
   organization or entity with a financial interest in or financial
   conflict with the subject matter or materials discussed in the
   manuscript apart from those disclosed.
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NR 150
TC 338
Z9 371
U1 15
U2 206
PU FUTURE MEDICINE LTD
PI LONDON
PA UNITEC HOUSE, 3RD FLOOR, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON, N3
   1QB, ENGLAND
SN 1741-0541
EI 1744-828X
J9 PERS MED
JI Pers. Med.
PD SEP
PY 2018
VL 15
IS 5
BP 429
EP 448
DI 10.2217/pme-2018-0044
PG 20
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Pharmacology & Pharmacy
GA GZ3RZ
UT WOS:000449305000001
PM 30259801
OA Green Submitted, hybrid
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Keskek, SÖ
   Kirim, S
   Turhan, A
   Turhan, FG
AF Keskek, Sakir Ozgur
   Kirim, Sinan
   Turhan, Ali
   Turhan, Fevziye Gulcin
TI Depression in subjects with beta-thalassemia minor
SO ANNALS OF HEMATOLOGY
LA English
DT Article
DE Beta-thalassemia minor; Depression; Hamilton depression rating scale;
   Hemoglobin A(2)
ID BIPOLAR AFFECTIVE-DISORDER; PSYCHIATRIC-DISORDERS; MEDICAL CONDITIONS;
   METABOLIC SYNDROME; CHRONIC DISEASES; SYMPTOMS
AB Beta-thalassemia minor is a common genetic blood disorder in Mediterranean countries such as Turkey. Additionally, depression is one of the most widespread mental disorders that affect people worldwide, and its prevalence is increasing with co-occurring medical conditions. The aim of this study was to determine whether the frequency of depression is elevated in subjects with beta-thalassemia minor. A total of 106 subjects were included in this study, of which 53 participants were diagnosed with beta-thalassemia minor. The other 53 participants were otherwise healthy. Hemoglobin electrophoresis and a complete blood count were performed in all subjects, and all participants were evaluated using the Hamilton Depression Rating Scale (HDRS). The HDRS scores of the subjects with beta-thalassemia minor were higher than those in the healthy subjects (p < 0.001). Additionally, the hemoglobin A(2) levels were positively associated with the HDRS scores (p < 0.0001, r = 0.482). This study suggests a possible association between depression and beta-thalassemia minor, in which the risk of depression may be increased in subjects with this condition.
C1 [Keskek, Sakir Ozgur; Kirim, Sinan; Turhan, Ali] Numune Educ & Res Hosp, Dept Internal Med, TR-01240 Adana, Turkey.
   [Turhan, Fevziye Gulcin] Numune Educ & Res Hosp, Dept Family Med, TR-01240 Adana, Turkey.
C3 Adana Numune Training & Research Hospital; Adana Numune Training &
   Research Hospital
RP Keskek, SÖ (corresponding author), Numune Educ & Res Hosp, Dept Internal Med, TR-01240 Adana, Turkey.
EM drkeskek@yahoo.com
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NR 27
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U2 8
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0939-5555
EI 1432-0584
J9 ANN HEMATOL
JI Ann. Hematol.
PD DEC
PY 2013
VL 92
IS 12
BP 1611
EP 1615
DI 10.1007/s00277-013-1851-9
PG 5
WC Hematology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Hematology
GA 250VJ
UT WOS:000326884100004
PM 23892926
DA 2025-06-11
ER

PT J
AU Gulhan, PY
   Ataoglu, O
   Balbay, EG
   YAsli, NE
   Annakkaya, AN
AF Gulhan, Pinar Yildiz
   Ataoglu, Ozlem
   Balbay, Ege Golec
   YAsli, Nevra Ezgi
   Annakkaya, Ali Nihat
TI The Evaluation of Eating Attitudes in Patients with Sarcoidosis
SO KONURALP TIP DERGISI
LA English
DT Article
DE Depression; Eating Behavior; Sarcoidosis
ID ATS/ERS/WASOG STATEMENT; DISORDERS; SYMPTOMS; OBESITY; INDEX
AB Objective: The aim of this present study was to investigate the eating attitudes of sarcoidosis patients.
   Methods: 50 patients with sarcoidosis and 45 healthy individuals without chronic disease were included to study. All participants evaluated for metabolic syndrome (MetS) according to National Cholesterol Education Program's Adult Treatment Panel III (NCEP-ATP III) criteria. Eating Attitude Test (EAT) and Beck Depression Inventory (BDI) were applied to all participants. All participants evaluated for metabolic syndrome (MetS). The cut-off scores of the tests were 30 for BDI and 17 for BDI.
   Results: When sarcoidosis cases and control group were evaluated according to EAT and BDI cut-off scores; it was found that the prevalence of deterioration in eating behavior was higher in patients with sarcoidosis than healthy controls but the prevalence of depression was not higher (p=0.018, p=0.874 respectively).We found that total EAT scores were significantly higher in sarcoidosis patients who has MetS. MetS(-); EAT: 15 +/- 7, MetS(+); EAT: 27 +/- 10 p<0.001.
   Conclusions: This study is important to show connection between the sarcoidosis and disordered eating attitudes. It is not adequate to establish the presence of comorbidities alone. Defining risk factors leading to comorbidities is also important in patients with sarcoidosis. If causative factors are detected, controlling them by a multidisciplinary approach will prevent the onset of comorbidities and also provide satisfactory management of sarcoidosis.
C1 [Gulhan, Pinar Yildiz; Ataoglu, Ozlem; Balbay, Ege Golec; YAsli, Nevra Ezgi; Annakkaya, Ali Nihat] Duzce Univ, Fac Med, Dept Pulmonol, Konuralp Campus, TR-81620 Duzce, Turkey.
C3 Duzce University
RP Gulhan, PY (corresponding author), Duzce Univ, Fac Med, Dept Pulmonol, Konuralp Campus, TR-81620 Duzce, Turkey.
EM pinaryildiz691@hotmail.com
RI Balbay, Ege/V-5497-2017; Ataoglu, Ozlem/MBH-0995-2025; yildiz gulhan,
   pinar/AAW-3004-2020; Annakkaya, Ali Nihat/A-8741-2017
OI Yasli, Nevra Ezgi/0000-0002-0970-6064; Annakkaya, Ali
   Nihat/0000-0002-7661-8830; Yildiz Gulhan, Pinar/0000-0002-5347-2365
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NR 23
TC 0
Z9 0
U1 0
U2 0
PU DUZCE UNIV
PI DUZCE
PA KONURALP YERLESKESI, DUZCE, 81620, TURKEY
SN 1309-3878
J9 KONURALP TIP DERG
JI Konuralp Tip Derg.
PY 2020
VL 12
IS 1
BP 112
EP 117
DI 10.18521/ktd.629782
PG 6
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA KS6ZR
UT WOS:000518456300017
OA Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Zhou, MS
   Wang, AM
   Yu, H
AF Zhou, Ming-Sheng
   Wang, Aimei
   Yu, Hong
TI Link between insulin resistance and hypertension: What is the evidence
   from evolutionary biology?
SO DIABETOLOGY & METABOLIC SYNDROME
LA English
DT Review
DE Insulin resistance; Hypertension; Evolution; Inflammation and sodium
ID SALT-SENSITIVE HYPERTENSION; OXIDATIVE STRESS; ENDOTHELIAL DYSFUNCTION;
   VASCULAR INFLAMMATION; THRIFTY PHENOTYPES; BLOOD-PRESSURE; OBESITY;
   METABOLISM; SYSTEM; ALDOSTERONE
AB Insulin resistance and hypertension are considered as prototypical "diseases of civilization" that are manifested in the modern environment as plentiful food and sedentary life. The human propensity for insulin resistance and hypertension is a product, at least in part, of our evolutionary history. Adaptation to ancient lifestyle characterized by a low sodium, low-calorie food supply and physical stress to injury response has driven our evolution to shape and preserve a thrifty genotype, which is favorite with energy-saving and sodium conservation. As our civilization evolved, a sedentary lifestyle and sodium-and energy-rich diet, the thrifty genotype is no longer advantageous, and may be maladaptive to disease phenotype, such as hypertension, obesity and insulin resistance syndrome. This article reviews human evolution and the impact of the modern environment on hypertension and insulin resistance.
C1 [Zhou, Ming-Sheng; Wang, Aimei] Liaoning Med Univ, Dept Physiol, Jinzhou, Liaoning, Peoples R China.
   [Yu, Hong] Zhejiang Univ, Sch Med, Affiliated Hosp 2, Dept Cardiol, Hangzhou 310003, Zhejiang, Peoples R China.
C3 Jinzhou Medical University; Zhejiang University
RP Zhou, MS (corresponding author), Liaoning Med Univ, Dept Physiol, 40,Sect 3 Songpo Rd, Jinzhou, Liaoning, Peoples R China.
EM zhoums1963@163.com; yuvascular@163.com
FU Florida JEK Biomedical Research grant; AHA National Scientist
   Development Award; National Natural Science Foundation Of China
   [31271585];  [2012CBA1305]
FX This work was supported by a Florida JEK Biomedical Research grant and
   AHA National Scientist Development Award to MSZ, and grants from
   National Natural Science Foundation Of China (31271585) and Minister of
   Science and Technology of China (2012CBA1305) to HY.
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NR 61
TC 139
Z9 152
U1 3
U2 43
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1758-5996
J9 DIABETOL METAB SYNDR
JI Diabetol. Metab. Syndr.
PD JAN 31
PY 2014
VL 6
AR 12
DI 10.1186/1758-5996-6-12
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA AF3LB
UT WOS:000334612700001
PM 24485020
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Bannai, A
   Tamakoshi, A
AF Bannai, Akira
   Tamakoshi, Akiko
TI The association between long working hours and health: A systematic
   review of epidemiological evidence
SO SCANDINAVIAN JOURNAL OF WORK ENVIRONMENT & HEALTH
LA English
DT Review
DE all-cause mortality; anxiety; circulatory disease; depression; diabetes
   mellitus; health-related behavior; overtime; shift work; sleep; working
   time
ID CORONARY-HEART-DISEASE; MACHINERY MANUFACTURING COMPANY; II PROSPECTIVE
   COHORT; WHITE-COLLAR WORKERS; OVERTIME WORK; SHIFT WORK;
   CARDIOVASCULAR-SYSTEM; DIABETES-MELLITUS; JAPANESE MEN; RISK
AB Objectives Many studies have investigated the association between long working hours and health. By focusing on differences in the definition of long working hours and the influence of shift work, we attempt to explain why the results of these studies remain inconclusive.
   Methods We defined long working hours as working time greater than around 40 hours per week or 8 hours per day. Since previous studies have indicated that shift work is detrimental to health, we minimized the influence of shift work in the studies. We also placed importance on the existence of reference groups since this made the results clearer. Based on these points, we analyzed previous studies to clarify the epidemiological evidence regarding the association between long working hours and health. We established inclusion criteria and carried out a systematic search for articles published in the Medline and PsycINFO databases between 1995-2012.
   Results We identified a total of 17 articles and 19 studies (12 prospective cohort and 7 cross-sectional studies). The outcomes were all-cause mortality, circulatory disease, diabetes mellitus, metabolic syndrome, depressive state, anxiety, other psychological disorders, sleep condition, cognitive function, and health-related behavior. Long working hours had significant adverse effects on most health outcomes.
   Conclusions We concluded that working long hours is associated with depressive state, anxiety, sleep condition, and coronary heart disease. However, further studies that appropriately deal with the definition of long working hours and shift work are needed.
C1 [Bannai, Akira; Tamakoshi, Akiko] Hokkaido Univ, Grad Sch Med, Dept Publ Hlth, Sapporo, Hokkaido 0608638, Japan.
C3 Hokkaido University
RP Tamakoshi, A (corresponding author), Hokkaido Univ, Grad Sch Med, Dept Publ Hlth, Kita Ku, Kita 15 Jo Nishi 7 Chome, Sapporo, Hokkaido 0608638, Japan.
EM tamaa@med.hokudai.ac.jp
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NR 42
TC 464
Z9 504
U1 8
U2 226
PU SCANDINAVIAN JOURNAL WORK ENVIRONMENT & HEALTH
PI HELSINKI
PA TOPELIUKSENKATU 41A, SF-00250 HELSINKI, FINLAND
SN 0355-3140
EI 1795-990X
J9 SCAND J WORK ENV HEA
JI Scand. J. Work Environ. Health
PD JAN
PY 2014
VL 40
IS 1
BP 5
EP 18
DI 10.5271/sjweh.3388
PG 14
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA AD5VN
UT WOS:000333321400002
PM 24100465
OA hybrid
DA 2025-06-11
ER

PT J
AU Parwani, K
   Mandal, P
AF Parwani, Kirti
   Mandal, Palash
TI Role of advanced glycation end products and insulin resistance in
   diabetic nephropathy
SO ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
LA English
DT Review
DE Advanced glycation end products; insulin resistance; receptor for
   advanced glycation end products; endoplasmic reticulum stress; diabetic
   nephropathy
ID ENDOPLASMIC-RETICULUM STRESS; INDUCED PODOCYTE APOPTOSIS; UNFOLDED
   PROTEIN RESPONSE; OXIDATIVE STRESS; METABOLIC SYNDROME;
   CARDIOVASCULAR-DISEASE; URSODEOXYCHOLIC ACID; DOWN-REGULATION; ELEVATED
   LEVELS; RECEPTOR
AB Metabolic syndrome (MetS), i.e. a cluster of physiological and biochemical abnormalities can lead to diabetic nephropathy (DN). Insulin resistance, impaired fasting glucose are the main signs and symptoms of MetS. Excess sugar can induce various substantial structural changes like formation of advanced glycation end products (AGEs). AGEs are formed due to reaction of reducing sugars with amino groups of proteins, lipids and nucleic acids. AGEs when bound to the receptor for advanced glycation end products (RAGE) activate increased production of pro-inflammatory markers like interleukin-6 (IL-6), tumour necrosis factor alpha (TNF-alpha) along with induction of endoplasmic reticulum (ER) stress. Accumulation of AGEs, enhanced reactive oxygen species (ROS) generation and activation of protein kinase C (PKC), are considered to induce glomerular hypertrophy, podocyte apoptosis, therefore contributing to the development and progression of DN. In this review, we decipher different biochemical and physiological factors that link AGEs and DN.
C1 [Parwani, Kirti; Mandal, Palash] Charotar Univ Sci & Technol, PD Patel Inst Appl Sci, Dept Biol Sci, Changa 388421, Gujarat, India.
C3 Charotar University of Science & Technology - Charusat
RP Mandal, P (corresponding author), Charotar Univ Sci & Technol, PD Patel Inst Appl Sci, Dept Biol Sci, Changa 388421, Gujarat, India.
EM palashmandal.bio@charusat.ac.in
RI Mandal, Prof. Palash/I-5238-2019; Parwani, Kirti/KOC-3945-2024
OI MANDAL, PALASH/0000-0001-6612-3773
FU Charotar University of Science Technology
FX The author thanks Charotar University of Science & Technology for
   providing the fellowship.
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NR 155
TC 55
Z9 59
U1 0
U2 18
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1381-3455
EI 1744-4160
J9 ARCH PHYSIOL BIOCHEM
JI Arch. Physiol. Biochem.
PD JAN 2
PY 2023
VL 129
IS 1
BP 95
EP 107
DI 10.1080/13813455.2020.1797106
EA JUL 2020
PG 13
WC Biochemistry & Molecular Biology; Biophysics; Endocrinology &
   Metabolism; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Endocrinology &
   Metabolism; Physiology
GA 8N8BB
UT WOS:000555147100001
PM 32730131
DA 2025-06-11
ER

PT J
AU Castelli, T
   Russo, GI
   Reale, G
   Privitera, S
   Chisari, M
   Fragalà, E
   Favilla, V
   Cimino, S
   Morgia, G
AF Castelli, Tommaso
   Russo, Giorgio Ivan
   Reale, Giulio
   Privitera, Salvatore
   Chisari, Mario
   Fragala, Eugenia
   Favilla, Vincenzo
   Cimino, Sebastiano
   Morgia, Giuseppe
TI Metabolic syndrome and prostatic disease: potentially role of
   polyphenols in preventive strategies. A review
SO INTERNATIONAL BRAZ J UROL
LA English
DT Review
DE Oxidative Stress; Prostatic Hyperplasia; Prostatic Neoplasms;
   Polyphenols
ID URINARY-TRACT SYMPTOMS; GREEN TEA POLYPHENOLS; GROWTH-FACTOR; OXIDATIVE
   STRESS; HEME OXYGENASE-1; SERENOA-REPENS; CANCER CELLS; HYPERPLASIA;
   CHEMOPREVENTION; INFLAMMATION
AB Benign prostatic hyperplasia and prostate cancer are two common urological diseases of the elderly. Scientific community has always looked for a link that could explain the correlation between the two diseases and the role of chronic inflammation in the pathogenesis of BPH and PCa. As shown by the reports of the two diseases relationship with oxidative stress and metabolic syndrome, the use of compounds with antioxidant action could therefore affect both the symptoms and their onset. Polyphenols appear to act not only against oxidative stress but also at different levels. The aim of this review is to evaluate the role of the most important polyphenols on these two urological diseases. As antioxidants these compounds seems to have a direct action on the cell cycle and hormone function, important for both prostate cancer and BPH. Despite a large number of articles about the relationship of the polyphenols with prostate cancer, very little evidence exists for BPH. Additional clinical trials or meta-analysis are necessary on this topic.
C1 [Castelli, Tommaso; Russo, Giorgio Ivan; Reale, Giulio; Privitera, Salvatore; Chisari, Mario; Fragala, Eugenia; Favilla, Vincenzo; Cimino, Sebastiano; Morgia, Giuseppe] Univ Catania, Fac Med Policlin, Dipartimento Urol, I-95124 Catania, Italy.
C3 University of Catania
RP Russo, GI (corresponding author), Univ Catania, Fac Med Policlin, Dipartimento Urol, Italia Sch Med,Policlin Hosp, I-95124 Catania, Italy.
EM giorgioivan@virgilio.it
RI Favilla, Vincenzo/AAB-5801-2022; Reale, Giulio/AAD-1040-2020; Russo,
   Giorgio/I-3347-2019
OI Reale, Giulio/0000-0003-1445-6191; Russo, Giorgio
   Ivan/0000-0003-4687-7353
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NR 55
TC 10
Z9 10
U1 0
U2 13
PU BRAZILIAN SOC UROL
PI RIO DE JANEIRO
PA RUA BAMBINA, 153, RIO DE JANEIRO, 2251-050, BRAZIL
SN 1677-5538
EI 1677-6119
J9 INT BRAZ J UROL
JI Int. Braz J Urol
PD MAY-JUN
PY 2016
VL 42
IS 3
BP 422
EP 430
DI 10.1590/S1677-5538.IBJU.2015.0095
PG 9
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA DR7FU
UT WOS:000380066200005
PM 27286103
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Cannizzo, B
   Quesada, I
   Militello, R
   Amaya, C
   Miatello, R
   Cruzado, M
   Castro, C
AF Cannizzo, B.
   Quesada, I.
   Militello, R.
   Amaya, C.
   Miatello, R.
   Cruzado, M.
   Castro, C.
TI Tempol attenuates atherosclerosis associated with metabolic syndrome via
   decreased vascular inflammation and NADPH-2 oxidase expression
SO FREE RADICAL RESEARCH
LA English
DT Article
DE NADPH oxidase; atherosclerosis; oxidative stress; tempol
ID SPONTANEOUSLY HYPERTENSIVE-RATS; OXIDATIVE STRESS; NAD(P)H OXIDASE;
   ANGIOTENSIN-II; E-SELECTIN; ADHESION; DISEASE; VCAM-1; ICAM-1;
   PROGRESSION
AB Oxidative stress is an important factor in the generation of vascular injury in atherosclerosis. Chronic administration of fructose in rodents is able to facilitate oxidative damage. In the present study we evaluated the role of Tempol, a superoxide dismutase mimetic, on the effect of high fructose intake in apolipoprotein E-deficient (ApoE-KO) mice. Rodents were fed with fructose overload (FF, 10% w/v) for 8 weeks and treated with Tempol 1 mg/kg/day the latest 4 weeks. Tempol revert the pro-oxidant effects caused by FF, diminished lipid peroxidation and impaired vascular NADPH oxidase system through the downregulation of p47phox expression in the vascular wall. Tempol inhibited the expression of vascular adhesion molecule 1 (VCAM-1) in aorta and reduced the development of atheroma plaques. Our results indicate that tempol attenuates oxidative stress by interfering with the correct assembly of Nox2 oxidase complex in the vascular wall and is able to reduce atherosclerosis. Thus tempol represents a potential therapeutic target for preventing risk factors associated with metabolic syndrome.
C1 [Cannizzo, B.; Quesada, I.; Cruzado, M.; Castro, C.] Natl Univ Cuyo, Sch Med Sci, Inst Med & Expt Biol Cuyo IMBECU CONICET, Vasc Biol Lab, Mendoza, Argentina.
   [Militello, R.; Amaya, C.] Natl Univ Cuyo, Sch Med Sci, Inst Histol & Embryol IHEM CONICET, Cellular & Mol Biol Lab, Mendoza, Argentina.
   [Miatello, R.] Natl Univ Cuyo, Fac Med Sci, Inst Expt Med & Biol Cuyo IMBECU CONICET, Cardiovasc Physiol Lab, Mendoza, Argentina.
C3 University Nacional Cuyo Mendoza; Consejo Nacional de Investigaciones
   Cientificas y Tecnicas (CONICET); University Nacional Cuyo Mendoza;
   Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET);
   Instituto de Medicina y BiologIa Experimental de Cuyo (IMBECU);
   University Nacional Cuyo Mendoza
RP Castro, C (corresponding author), Univ Nacl Cuyo, Fac Ciencias Med, IMBECU CONICET, Avda Libertador 80, RA-5500 Mendoza, Argentina.
EM ccastro@fcm.uncu.edu.ar
OI Castro, Claudia/0000-0002-8428-2484
FU National University of Cuyo [06/J299]; National Agency of Scientific and
   Technological Promotion, Fund for Scientific and Technological Research
   (FONCyT) [PICT 2006-01955]
FX This work was supported by grant 06/J299 (to C Castro), 2009-2011 from
   Secretary of Science and Technology, National University of Cuyo, and
   the National Agency of Scientific and Technological Promotion, Fund for
   Scientific and Technological Research (FONCyT; PICT 2006-01955, to R
   Miatello). CB, RA and CA (doctoral fellows) and IQ (post-doctoral
   fellow) from CONICET.
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NR 36
TC 26
Z9 27
U1 0
U2 3
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1071-5762
EI 1029-2470
J9 FREE RADICAL RES
JI Free Radic. Res.
PD MAY
PY 2014
VL 48
IS 5
BP 526
EP 533
DI 10.3109/10715762.2014.889295
PG 8
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA AE8TC
UT WOS:000334273900002
PM 24490696
OA Green Published
DA 2025-06-11
ER

PT J
AU Reitz, CJ
   Alibhai, FJ
   de Lima-Seolin, BG
   Nemec-Bakk, A
   Khaper, N
   Martino, TA
AF Reitz, Cristine J.
   Alibhai, Faisal J.
   de Lima-Seolin, Bruna Gazzi
   Nemec-Bakk, Ashley
   Khaper, Neelam
   Martino, Tami A.
TI Circadian mutant mice with obesity and metabolic syndrome are resilient
   to cardiovascular disease
SO AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
LA English
DT Article
DE cardiovascular; circadian; high-fat diet; obesity; oxidative stress;
   resilience
ID ACTIVATED-RECEPTOR-GAMMA; GENE-EXPRESSION; OXIDATIVE STRESS; CLOCK;
   HEART; TIME; DISRUPTION; RHYTHMS; PREVENTION; DISTURBANCES
AB Obesity and metabolic syndrome commonly underlie cardiovascular disease. Clock(Delta 19/Delta 19) mice fed a normal diet develop obesity and metabolic syndrome; however, it is not known whether they develop or are resilient to cardiovascular disease. We found that Clock(Delta 19/Delta 19) mice do not develop cardiac dysfunction, despite their underlying conditions. Moreover, in contrast to wild-type controls fed a high-fat diet (HFD), Clock(Delta 19/Delta 19) HFD mice still do not develop cardiovascular disease. Indeed, Clock(Delta 19/Delta 19) HFD mice have preserved heart weight despite their obesity, no cardiomyocyte hypertrophy, and preserved heart structure and function, even after 24 wk of a HFD. To determine why Clock(Delta 19/Delta 19) mice are resilient to cardiac dysfunction despite their underlying obesity and metabolic conditions, we examined global cardiac gene expression profiles by microarray and bioinformatics analyses, revealing that oxidative stress pathways were involved. We examined the pathways in further detail and found that 1) SIRT-dependent oxidative stress pathways were not directly involved in resilience; 2) 4-hydroxynonenal (4-HNE) increased in wild-type HFD but not Clock(Delta 19/Delta 19) mice, suggesting less reactive oxygen species in Clock(Delta 19/Delta 19) mice; 3) cardiac catalase (CAT) and glutathione peroxidase (GPx) increased, suggesting strong antioxidant defenses in the hearts of Clock(Delta 19/Delta 19) mice; and 4) Pparc was upregulated in the hearts of Clock(Delta 19/Delta 19) mice; this circadian-regulated gene drives transcription of CAT and GPx, providing a molecular basis for resilience in the Clock(Delta 19/Delta 19) mice. These findings shed new light on the circadian regulation of oxidative stress and demonstrate an important role for the circadian mechanism in resilience to cardiovascular disease.
   NEW & NOTEWORTHY We examined whether obesity and metabolic syndrome underlie the development of cardiac dysfunction in circadian mutant Clock(Delta 19/Delta 19) mice. Surprisingly, we demonstrate that although Clock(Delta 19/Delta 19) mice develop metabolic dysfunction, they are protected from cardiac hypertrophy, left ventricular remodeling, and diastolic dysfunction, in contrast to wild-type controls, even when challenged with a chronic high-fat diet. These findings shed new light on the circadian regulation of oxidative stress pathways, which can mediate resilience to cardiovascular disease.
C1 [Reitz, Cristine J.; Alibhai, Faisal J.; Martino, Tami A.] Univ Guelph, Ctr Cardiovasc Invest, Dept Biomed Sci, Guelph, ON, Canada.
   [de Lima-Seolin, Bruna Gazzi; Nemec-Bakk, Ashley; Khaper, Neelam] Lakehead Univ, Northern Ontario Sch Med, Med Sci Div, Thunder Bay, ON, Canada.
C3 University of Guelph; Lakehead University; NOSM University
RP Martino, TA (corresponding author), Univ Guelph, Ctr Cardiovasc Invest, Dept Biomed Sci, Guelph, ON, Canada.
EM tmartino@uoguelph.ca
RI Alibhai, Faisal/MGW-0772-2025
OI Nemec-Bakk, Ashley/0000-0001-9722-9642; GAZZI DE LIMA SEOLIN,
   BRUNA/0000-0002-0999-9100; Reitz, Cristine/0000-0002-1748-0501; Alibhai,
   Faisal/0000-0002-8145-4682
FU Canadian Institutes of Health Research (CIHR); Heart and Stroke
   Foundation of Canada; CIHR Canada Graduate Scholarship doctoral award
FX This work is supported by grants from the Canadian Institutes of Health
   Research (CIHR) and the Heart and Stroke Foundation of Canada (to T. A.
   Martino) and CIHR Canada Graduate Scholarship doctoral award (to C. J.
   Reitz).
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NR 68
TC 11
Z9 11
U1 0
U2 4
PU AMER PHYSIOLOGICAL SOC
PI Rockville
PA 6120 Executive Blvd, Suite 600, Rockville, MD, UNITED STATES
SN 0363-6135
EI 1522-1539
J9 AM J PHYSIOL-HEART C
JI Am. J. Physiol.-Heart Circul. Physiol.
PD NOV
PY 2020
VL 319
IS 5
BP H1097
EP H1111
DI 10.1152/ajpheart.00462.2020
PG 15
WC Cardiac & Cardiovascular Systems; Physiology; Peripheral Vascular
   Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Physiology
GA QV1SN
UT WOS:000627758100006
PM 32986958
OA hybrid
DA 2025-06-11
ER

PT J
AU Oliveira, PS
   Chaves, VC
   Soares, MSP
   Bona, NP
   Mendonça, LT
   Carvalho, FB
   Gutierres, JM
   Vasconcellos, FA
   Vizzotto, M
   Vieira, A
   Spanevello, RM
   Reginatto, FH
   Lencina, CL
   Stefanello, FM
AF Oliveira, Pathise Souto
   Chaves, Vitor Clasen
   Pereira Soares, Mayara Sandrielly
   Bona, Natalia Pontes
   Mendonca, Lorenco Torres
   Carvalho, Fabiano Barbosa
   Gutierres, Jessie Martins
   Vasconcellos, Flavia Aleixo
   Vizzotto, Marcia
   Vieira, Andriele
   Spanevello, Roselia Maria
   Reginatto, Flavio Henrique
   Lencina, Claiton Leoneti
   Stefanello, Francieli Moro
TI Southern Brazilian native fruit shows neurochemical, metabolic and
   behavioral benefits in an animal model of metabolic syndrome
SO METABOLIC BRAIN DISEASE
LA English
DT Article
DE Metabolic syndrome; Highly palatable diet; P. cattleianum; Natural
   products; Phenolic compounds; Neuroprotection
ID OXIDATIVE STRESS; INSULIN-RESISTANCE; K+-ATPASE; NA+,K+-ATPASE ACTIVITY;
   REACTIVE OXYGEN; DEPRESSION; RAT; INFLAMMATION; EXTRACT; NA+
AB In this work, we evaluated the effects of Psidium cattleianum (Red Type) (PcRT) fruit extract on metabolic, behavioral, and neurochemical parameters in rats fed with a highly palatable diet (HPD) consisted of sucrose (65% carbohydrates being 34% from condensed milk, 8% from sucrose and 23% from starch, 25% protein and 10% fat). Animals were divided into 4 groups: standard chow, standard chow + PcRT extract (200 mg/Kg/day by gavage), HPD, HPD + extract. The animals were treated for 150 days. Concerning chemical profiling, LC/PDA/MS/MS analysis revealed cyanidin-3-O-glucoside as the only anthocyanin in the PcRT extract. Our results showed that the animals exposed to HPD presented glucose intolerance, increased weight gain and visceral fat, as well as higher serum levels of glucose, triacylglycerol, total cholesterol, LDL-cholesterol and interleukin-6. These alterations were prevented by PcRT. In addition, HPD caused an increase in immobility time in a forced swimming test and the fruit extract prevented this alteration, indicating an antidepressant-like effect. PcRT treatment also prevented increased acetylcholinesterase activity in the prefrontal cortex caused by HPD consumption. Moreover, PcRT extract was able to restore Ca2+-ATPase activity in the prefrontal cortex, hippocampus, and striatum, as well as Na+,K+-ATPase activity in the prefrontal cortex and hippocampus. PcRT treatment decreased thiobarbituric acid-reactive substances, nitrite, and reactive oxygen species levels and prevented the reduction of superoxide dismutase activity in all cerebral structures of the HPD group. Additionally, HPD decreased catalase in the hippocampus and striatum. However, the extract prevented this change in the hippocampus. Our results showed that this berry extract has antihyperglycemic and antihyperlipidemic effects, and neuroprotective properties, proving to be a potential therapeutic agent for individuals with metabolic syndrome.
C1 [Oliveira, Pathise Souto; Bona, Natalia Pontes; Mendonca, Lorenco Torres; Lencina, Claiton Leoneti; Stefanello, Francieli Moro] Univ Fed Pelotas, Lab Biomarcadores, Ctr Ciencias Quim Farmaceut & Alimentos, Campus Univ S-N, Pelotas, RS, Brazil.
   [Chaves, Vitor Clasen; Reginatto, Flavio Henrique] Univ Fed Santa Catarina, Lab Farmacognosia, Programa Posgrad Biotecnol & Biociencias, Florianopolis, SC, Brazil.
   [Pereira Soares, Mayara Sandrielly; Spanevello, Roselia Maria] Univ Fed Pelotas, Lab Neuroquim Inflamacao & Canc, Ctr Ciencias Quim Farmaceut & Alimentos, Campus Univ S-N, Pelotas, RS, Brazil.
   [Carvalho, Fabiano Barbosa; Gutierres, Jessie Martins] Univ Fed Santa Maria, Programa Posgrad Ciencias Biol Bioquim Toxicol, Dept Bioquim & Biol Mol, Ctr Ciencias Nat & Exatas, Santa Maria, RS, Brazil.
   [Vasconcellos, Flavia Aleixo] Univ Fed Pelotas, Lab Quim Aplicada Bioativos, Ctr Ciencias Quim Farmaceut & Alimentos, Campus Univ S-N, Pelotas, RS, Brazil.
   [Vizzotto, Marcia] Empresa Brasileira Pesquisa Agr, Ctr Pesquisa Agr Clima Temperado, Pelotas, RS, Brazil.
   [Vieira, Andriele] Univ Extremo Sul Catarinense, Lab Fisiopatol, Programa Posgrad Ciencias Saude, Criciuma, SC, Brazil.
   [Stefanello, Francieli Moro] Univ Fed Pelotas, Campus Univ S-N, BR-96160000 Capao Do Leao, RS, Brazil.
C3 Universidade Federal de Pelotas; Universidade Federal de Santa Catarina
   (UFSC); Universidade Federal de Pelotas; Universidade Federal de Santa
   Maria (UFSM); Universidade Federal de Pelotas; Empresa Brasileira de
   Pesquisa Agropecuaria (EMBRAPA); Universidade do Extremo Sul
   Catarinense; Universidade Federal de Pelotas
RP Stefanello, FM (corresponding author), Univ Fed Pelotas, Lab Biomarcadores, Ctr Ciencias Quim Farmaceut & Alimentos, Campus Univ S-N, Pelotas, RS, Brazil.; Stefanello, FM (corresponding author), Univ Fed Pelotas, Campus Univ S-N, BR-96160000 Capao Do Leao, RS, Brazil.
EM francieli.stefanelo@ufpel.edu.br
RI Vasconcellos, F/E-4773-2016; Spanevello, Roselia/H-1610-2018; Gutierres,
   Jessie/D-6938-2013; Carvalho, Fabiano/J-6622-2013
OI Gutierres, Jessie/0000-0002-9574-4007; Carvalho,
   Fabiano/0000-0002-7927-1342; Spanevello, Roselia/0000-0002-5117-2000;
   REGINATTO, FLAVIO/0000-0002-4710-8540
FU Brazilian research funding agency FAPERGS; Brazilian research funding
   agency CAPES; Brazilian research funding agency CNPq
FX The Brazilian research funding agencies FAPERGS, CAPES and CNPq
   supported this study. We also thank Dr. Felipe Dal-Pizzol (Laboratory of
   Experimental Pathophysiology, University of Southern Santa Catarina,
   Brazil) for providing the kit to measure IL-6.
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NR 67
TC 14
Z9 14
U1 0
U2 5
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0885-7490
EI 1573-7365
J9 METAB BRAIN DIS
JI Metab. Brain Dis.
PD OCT
PY 2018
VL 33
IS 5
BP 1551
EP 1562
DI 10.1007/s11011-018-0262-y
PG 12
WC Endocrinology & Metabolism; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology
GA GU3DD
UT WOS:000445154200018
PM 29882020
DA 2025-06-11
ER

PT B
AU Miyata, T
   Yamamoto, M
   Izuhara, Y
AF Miyata, T
   Yamamoto, M
   Izuhara, Y
BE Baynes, JW
   Monnier, VM
   Ames, JM
   Thorpe, SR
TI From molecular footprints of disease to new therapeutic interventions in
   diabetic nephropathy
SO MAILLARD REACTION: CHEMISTRY AT THE INTERFACE OF NUTRITION, AGING, AND
   DISEASE
SE Annals of the New York Academy of Sciences-Series
LA English
DT Article; Proceedings Paper
CT 8th International Symposium on the Maillard Reaction
CY AUG 29-SEP 01, 2004
CL Charleston, SC
SP Asahi Kasei Pharma, Avents, BASF, Biostratum, Univ S Carolina, Coll Sci & Math, Danisco, Danone Vitapole, Ctr Rech Daniel Carasso, DSM, Estee Lauder Co, Inlight Solut, IUBMB, Juvenile Diabet Res Fdn, KOWA, Oregon State Univ, Linus Pauling Inst, LOreal, Med Univ S Carolina, Merck, NIA, Nestle, Renascience, Univ S Carolina, Res & Hlth Sci, Taisho Pharmaceut Co Ltd, UNILEVER
DE oxidative stress; protein modification; advanced glycation end products
   (AGEs); renoprotection; hypertension; metabolic syndrome; AGE inhibitor
ID GLYCATION END-PRODUCTS; OXIDATIVE STRESS; CARBONYL STRESS; CROSS-LINK;
   IN-VIVO; RENOPROTECTION; PROTEINS; OPB-9195; MICROALBUMINURIA;
   AMINOGUANIDINE
AB Proteins are particularly attractive targets for product analysis, which is used to understand pathology. Protein modifications, such as advanced glycation end products (AGES), serve as footprints of biochemical processes and also help in the search for novel agents that efficiently inhibit protein damage. Interestingly, several medical agents that are used clinically interfere with oxidative protein damage through different mechanisms characteristic of their chemical structures. We recently found that angiotensin II receptor blockers (ARBs) and angiotensin converting enzyme inhibitors (ACEIs) lower the in vitro formation of the AGES pentosidine and carboxymethyllysine. Their inhibition for AGE formation is more striking than aminoguanidine. Unlike aminoguanidine, ARBs and ACEIs do not trap reactive carbonyl precursors of AGES. Rather, they inhibit AGE formation, possibly as a result of their potent ability to scavenge hydroxyl radicals and to chelate the transition metals necessary for the Fenton reaction. We tested their AGE-lowering ability in vivo in a unique type-2 diabetic model with nephropathic SHR/NDmcr-cp rats, which exhibits the metabolic syndrome (obesity, hyperglycemia, hyperlipidemia, hyperinsulinemia) in addition to hypertension. Obesity and associated metabolic derangements, in addition to hypertension, markedly accelerate renal injury. Expectedly, correction of hyperglycemia and hyperinsulinemia partially but significantly improves renal injury. A low-calorie diet greatly improves renal injury despite persistent hypertension. Among antihypertensive agents, ARBs, unlike nifedipine and atenolol, are renoprotective despite persistent metabolic syndrome, but their action is independent of blood pressure lowering and is observed in a dose-dependent manner despite the complete blockade of angiotensin II receptor. Interestingly, the improvement of renal injury by ARBs as well as a low-calorie diet is associated with a significant reduction in local oxidative stress and AGE formation in the kidney. During the characterization of the AGE-lowering profile of our chemical compound libraries (similar to 2000), we identified several inhibitors of oxidative stress and advanced glycation. They are indeed renoprotective, independently of correction of hypertension and metabolic syndrome, in experimental diabetic nephropathy and other nephritis models. Altogether, our data are in good agreement with the recent therapeutic concept for diabetic nephropathy that multiple risk factor interventions are critical in the treatment of diabetic renal injury, and further implicate a therapeutic potential of inhibition of oxidative stress and advanced glycation.
C1 Tokai Univ, Inst Med Sci, Kanagawa 2591193, Japan.
C3 Tokai University
RP Tokai Univ, Inst Med Sci, Kanagawa 2591193, Japan.
EM t-miyata@is.icc.u-tokai.ac.jp
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NR 46
TC 10
Z9 14
U1 0
U2 4
PU NEW YORK ACAD SCIENCES
PI NEW YORK
PA 2 EAST 63RD ST, NEW YORK, NY 10021 USA
BN 1-57331-531-1
J9 ANN NY ACAD SCI
JI Ann.NY Acad.Sci.
PY 2005
VL 1043
BP 740
EP 749
DI 10.1196/annals.1333.086
PG 10
WC Biochemistry & Molecular Biology; Chemistry, Applied; Multidisciplinary
   Sciences; Physiology
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry; Science & Technology -
   Other Topics; Physiology
GA BCY08
UT WOS:000231834100086
PM 16037301
DA 2025-06-11
ER

PT J
AU Sadabadi, F
   Talkhi, N
   Omouri-Kharashtomi, M
   Mirzaei, M
   Soflaei, SS
   Rahimi, Z
   Shabani, N
   Latifi, M
   Sarabi, MM
   Iri, S
   Moghaddas, E
   Ferns, GA
   Esmaily, H
   Ghayour-Mobarhan, M
AF Sadabadi, Fatemeh
   Talkhi, Nasrin
   Omouri-Kharashtomi, Mahyaar
   Mirzaei, Mohammad
   Soflaei, Sara Saffar
   Rahimi, Zahra
   Shabani, Niloofar
   Latifi, Mohammadreza
   Sarabi, Mohammadreza Mohammadtaghizadeh
   Iri, Sarina
   Moghaddas, Elham
   Ferns, Gordon A.
   Esmaily, Habibollah
   Ghayour-Mobarhan, Majid
TI Association Between Socio-Economic Status (SES) and the Traditional Risk
   Factors of Cardiovascular Diseases (CVD): A Cross-Sectional MASHAD
   Cohort Study Results
SO HEALTH SCIENCE REPORTS
LA English
DT Article
DE cardiovascular disease; cohort study; CVD risk factors; metabolic
   syndrome; obesity; socioeconomic status; stress; women
ID METABOLIC SYNDROME; NATIONAL-HEALTH; OBESITY; ADULTS; PREVALENCE;
   DISPARITIES; EDUCATION; SMOKING; INCOME; COMORBIDITIES
AB Background and AimsSocio-economic status (SES) has been shown to be associated with cardiovascular disease. We aimed to investigate the relationship between SES and traditional risk factors for cardiovascular diseases in 35 to 65 adults of the MASHAD cohort study drawn from the second biggest city in Iran, Mashhad with a population of almost 3 million.MethodsIn this cross-sectional study, subjects were divided into three categories of SES status based on their education level, employment status, and monthly income using latent class analysis (LCA). The three SES of low, medium, and high classes were compared in terms of cardiovascular disease risk factors including diabetes mellitus, metabolic syndrome, obesity, dyslipidemia, and hypertension. p value less than 0.05 was considered as significant.ResultsA total number of 9704 participants were included in the study. According to goodness-of-fit measures and entropy the three-class model is the most optimal and suitable model here. Participants with a low SES had significantly lower means of age, physical activity level, waist circumference, systolic blood pressure and LDL-C, and higher means of weight, and hip circumferences. Also, the prevalence of smoking, hypertension and metabolic syndrome were lower in low SES group than the two other groups. Logistic regression showed that the odds of obesity in the high SES class was 1.3-fold higher than for the middle SES class. Moreover, the chance of metabolic syndrome and hypertension in the low SES class was respectively 0.81 and 0.83 of the middle SES class.ConclusionLower socio-economic was associated with metabolic syndrome and hypertension and obesity was associated with higher SES; it may therefore be necessary to develop more specific and personalized preventive policies for populations in each socio-economic class.
C1 [Sadabadi, Fatemeh; Soflaei, Sara Saffar; Esmaily, Habibollah] Mashhad Univ Med Sci, Metab Syndrome Res Ctr, Mashhad, Iran.
   [Talkhi, Nasrin; Shabani, Niloofar] Univ Tehran Med Sci, Sch Hlth, Dept Biostat, Tehran, Iran.
   [Omouri-Kharashtomi, Mahyaar] Ahvaz Jundishapur Univ Med Sci, Student Res Comm, Ahvaz, Iran.
   [Mirzaei, Mohammad; Iri, Sarina] Mashhad Univ Med Sci, Fac Med, Mashhad, Iran.
   [Soflaei, Sara Saffar; Esmaily, Habibollah] Mashhad Univ Med Sci, Int UNESCO Ctr Hlth Related Basic Sci & Human Nutr, Mashhad, Iran.
   [Rahimi, Zahra; Ghayour-Mobarhan, Majid] Mashhad Univ Med Sci, Sch Hlth, Dept Biostat, Mashhad, Iran.
   [Latifi, Mohammadreza; Sarabi, Mohammadreza Mohammadtaghizadeh] Islamic Azad Univ, Mashhad Branch, Dept Biol, Mashhad, Iran.
   [Moghaddas, Elham] Mashhad Univ Med Sci, Sch Med, Dept Parasitol & Mycol, Mashhad, Iran.
   [Ferns, Gordon A.] Brighton & Sussex Med Sch, Div Med Educ, Brighton, England.
   [Ghayour-Mobarhan, Majid] Mashhad Univ Med Sci, Social Determinants Hlth Res Ctr, Mashhad, Iran.
C3 Mashhad University of Medical Sciences; Tehran University of Medical
   Sciences; Ahvaz Jundishapur University of Medical Sciences (AJUMS);
   Mashhad University of Medical Sciences; Mashhad University of Medical
   Sciences; Mashhad University of Medical Sciences; Islamic Azad
   University; Mashhad University of Medical Sciences; University of
   Brighton; University of Sussex; Mashhad University of Medical Sciences
RP Esmaily, H (corresponding author), Mashhad Univ Med Sci, Metab Syndrome Res Ctr, Mashhad, Iran.; Esmaily, H (corresponding author), Mashhad Univ Med Sci, Int UNESCO Ctr Hlth Related Basic Sci & Human Nutr, Mashhad, Iran.; Ghayour-Mobarhan, M (corresponding author), Mashhad Univ Med Sci, Sch Hlth, Dept Biostat, Mashhad, Iran.; Ghayour-Mobarhan, M (corresponding author), Mashhad Univ Med Sci, Social Determinants Hlth Res Ctr, Mashhad, Iran.
EM EsmailyH@mums.ac.ir; GhayourM@mums.ac.ir
RI moghaddas, elham/K-8397-2016; Ghayour-Mobarhan, Majid/AAY-5963-2020;
   Rahimi, Zahra/ABI-0623-2022; Soflaei, Sara/AAI-1461-2019
FU The study was supported by the Mashhad University of Medical Sciences,
   no: 990679.; Mashhad University of Medical Sciences
FX This study was funded by Mashhad University of Medical Sciences.
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NR 75
TC 0
Z9 0
U1 2
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
EI 2398-8835
J9 HEALTH SCI REP-US
JI Health Sci. Rep.
PD MAY
PY 2025
VL 8
IS 5
AR e70721
DI 10.1002/hsr2.70721
PG 9
WC Public, Environmental & Occupational Health; Medicine, General &
   Internal
WE Emerging Sources Citation Index (ESCI)
SC Public, Environmental & Occupational Health; General & Internal Medicine
GA 2AY1D
UT WOS:001478321500001
PM 40309617
OA gold
DA 2025-06-11
ER

PT J
AU Tada, Y
   Kagota, S
   Matsumoto, M
   Naito, Y
   Shibata, H
   Nejime, N
   Tsujino, T
   Koshiba, M
   Masuyama, T
   Shinozuka, K
AF Tada, Yukari
   Kagota, Satomi
   Matsumoto, Mika
   Naito, Yoshiro
   Shibata, Hiromi
   Nejime, Namie
   Tsujino, Takeshi
   Koshiba, Masahiro
   Masuyama, Tohru
   Shinozuka, Kazumasa
TI Characterization of Cardiac Size and Function in SHRSP
   Z-Lepr<SUP>fa</SUP>/IzmDmcr Rats, a New Animal Model of Metabolic
   Syndrome
SO BIOLOGICAL & PHARMACEUTICAL BULLETIN
LA English
DT Article
DE metabolic syndrome; diastolic dysfunction; heart rate; hypertrophy;
   cardiac dysfunction; obesity
ID DIASTOLIC HEART-FAILURE; SHR/NDMCR-CP RATS; BRAIN NATRIURETIC PEPTIDE;
   LEFT ATRIAL SIZE; MYOCARDIAL COLLAGEN; NITRATIVE STRESS; DYSFUNCTION;
   OBESITY; PEROXYNITRITE; SYSTEM
AB Cardiac structural and functional abnormalities are observed in metabolic syndrome However, such changes have not been investigated in the SHRSP Z-Lepri(fa)/IzmDmcr rat (SHRSP-fatty) model of metabolic syndrome Here we compare cardiac size and hemodynamic function in these rats with their lean littermates (SHRSP) and normotensive control Wistar-Kyoto rats (WKY) In male 16-week-old SHRSP-fatty, we determined heart rate and systolic blood pressure (SBP) by tail-cuff, cardiac output (CO), subcutaneous peripheral blood flow (BF) and stroke volume (SV) by plethysmography, and systolic and diastolic functions by echocardiography We also assessed weight and collagen type I expression by Western blot in Isolated atrium and ventricle, and beat rate in isolated atrial preparation by myography Heart rate was lower in conscious SHRSP-fatty than SHRSP, and the beat rate of Isolated atria was lower in SHRSP-fatty and SHRSP than that of WKV Atrial weight was larger in SHRSP-fatty than others Ventricular weight of SHRSP-fatty and SHRSP was larger than WKY There were significant Inverse correlations between atrial weight and heart rate or beat rate in SHRSP-fatty SBP, CO, BF and SV were Increased in SHRSP-fatty similarly to SHRSP Increased deceleration time and decreased E/A ratio, and preserved fractional shortening were observed in SHRSP-fatty Expressions of collagen type I were Increased in atria and ventricle of SHRSP-fatty SHRSP-fatty with metabolic syndrome exhibit cardiac changes, including slowed heart rate, ventricular diastolic dysfunction, and fibrosis, and atrial enlargement SHRSP-fatty may be a useful rat model to study on cardiac abnormalities in metabolic syndrome
C1 [Tada, Yukari; Kagota, Satomi; Nejime, Namie; Shinozuka, Kazumasa] Mukogawa Womens Univ, Sch Pharm & Pharmaceut Sci, Dept Pharmacol, Nishinomiya, Hyogo 6638179, Japan.
   [Matsumoto, Mika; Naito, Yoshiro; Tsujino, Takeshi; Masuyama, Tohru] Hyogo Coll Med, Dept Internal Med, Div Cardiovasc, Nishinomiya, Hyogo 6638501, Japan.
   [Shibata, Hiromi; Koshiba, Masahiro] Hyogo Coll Med Hosp, Dept Clin Lab, Nishinomiya, Hyogo 6638501, Japan.
   [Shibata, Hiromi] Hyogo Univ Hlth Sci, Sch Pharm, Chuo Ku, Kobe, Hyogo 6508530, Japan.
C3 Mukogawa Women's University; Hyogo Medical University; Hyogo Medical
   University
RP Kagota, S (corresponding author), Mukogawa Womens Univ, Sch Pharm & Pharmaceut Sci, Dept Pharmacol, 11-68 Koshien Kvuban Cho, Nishinomiya, Hyogo 6638179, Japan.
FU Mukogawa Women's University; Ministry of Education, Culture, Sports,
   Science and Technology of Japan; Smoking Research Foundation, Japan
FX This research was partly supported by the Open Research Center Project
   of Mukogawa Women's University for studying lifestyle-related diseases,
   a Grant-in-Aid for Scientific Research from the Ministry of Education,
   Culture, Sports, Science and Technology of Japan, and a Grant from the
   Smoking Research Foundation, Japan
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NR 39
TC 16
Z9 17
U1 0
U2 1
PU PHARMACEUTICAL SOC JAPAN
PI TOKYO
PA 2-12-15 SHIBUYA, SHIBUYA-KU, TOKYO, 150-0002, JAPAN
SN 0918-6158
J9 BIOL PHARM BULL
JI Biol. Pharm. Bull.
PD DEC
PY 2010
VL 33
IS 12
BP 1971
EP 1976
DI 10.1248/bpb.33.1971
PG 6
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 688OZ
UT WOS:000284862200009
PM 21139235
OA Bronze
DA 2025-06-11
ER

PT J
AU Brown, ADH
   Barton, DA
   Lambert, GW
AF Brown, Alex D. H.
   Barton, David A.
   Lambert, Gavin W.
TI Cardiovascular Abnormalities in Patients with Major Depressive Disorder
   Autonomic Mechanisms and Implications for Treatment
SO CNS DRUGS
LA English
DT Review
ID CORONARY-HEART-DISEASE; SEROTONIN REUPTAKE INHIBITORS;
   SYMPATHETIC-NERVOUS-SYSTEM; C-REACTIVE PROTEIN; ACUTE
   MYOCARDIAL-INFARCTION; INDUCED SICKNESS BEHAVIOR; LEFT-VENTRICULAR MASS;
   LONG-TERM TREATMENT; RATE-VARIABILITY; METABOLIC SYNDROME
AB This article provides a detailed review of the association of major depression with coronary heart disease (CHD), examines the biological variables underpinning the linkage and discusses the clinical implications for treatment. When considering the co-morbidity between major depressive disorder (MDD) and CHD it is important to differentiate between (i) the prevalence and impact of MDD in those with existing CHID and (ii) MDD as a risk factor for the development of CHD. Whether the same biological mechanisms are at play in these two instances remains unknown. Depression is common in patients with CHID. Importantly, depression in these patients increases mortality. There is also consistent evidence that MDD is a risk factor for the development of CHD. The relative risk of developing CHD is proportional to the severity of depression and is independent of smoking, obesity, hypercholesterolaemia, diabetes mellitus and hypertension.
   There is a clear need to identify the underlying neurochemical mechanisms responsible for MDD and their linkage to the heart and vascular system. Of particular interest are activation of stress pathways, including both the sympathetic nervous system and hypothalamic-pituitary-adrenal axis, and inflammatory-mediated atherogenesis. Elevated sympathetic activity, reduced heart rate variability and increased plasma cortisol levels have been documented in patients with MDD. In addition to direct effects on the heart and vasculature, activation of stress pathways may also be associated with increased release of inflammatory cytokines such as interleukin-6 and tumour necrosis factor-alpha. Elevated levels of C-reactive protein are commonly observed in patients with MDD.
   The majority of investigations examining treatment of depression following myocardial infarction have focused on safety and efficacy; there is little evidence to indicate that treating depression in these patients improves survival. Given that strategies for preventive therapy remain incompletely formulated, future research should focus on generating a better understanding of the neurobiology of MDD and heart disease as a basis for rational and effective therapy.
C1 [Barton, David A.; Lambert, Gavin W.] Baker IDI Heart & Diabet Inst, Human Neurotransmitters Lab, Melbourne, Vic 8008, Australia.
   [Brown, Alex D. H.] Ctr Indigenous Vasc & Diabet Res, Alice Springs, NT, Australia.
   [Barton, David A.] Monash Univ, Dept Psychol Med, Melbourne, Vic 3004, Australia.
   [Barton, David A.] Aged Persons Mental Hlth Program NW Mental Hlth, Melbourne, Vic, Australia.
C3 Baker Heart and Diabetes Institute; Monash University
RP Lambert, GW (corresponding author), Baker IDI Heart & Diabet Inst, Human Neurotransmitters Lab, POB 6492,St Kilda Rd Cent, Melbourne, Vic 8008, Australia.
EM gavin.lambert@bakeridi.edu.au
RI Barton, David/A-9016-2013; Brown, Alex/E-8614-2010; Lambert,
   Gavin/E-7384-2010
OI Brown, Alex/0000-0003-2112-3918; Lambert, Gavin/0000-0003-0315-645X
FU National Health and Research Council of Australia; National Heart
   Foundation of Australia; Servier; Eli Lilly; Pfizer; Solvay
   Pharmaceuticals; Wyeth Pharmaceuticals; Lundbeck and AstraZeneca
FX Supported by grants from the National Health and Research Council of
   Australia and by the National Heart Foundation of Australia. The funding
   agencies played no role in the preparation of this manuscript and the
   authors report no conflicts of interest related to the submission. Dr
   Lambert has received honoraria from Wyeth Pharmaceuticals and Pfizer for
   presentations given. Dr Brown has received grants from Pfizer for
   previous investigator-driven research that was not related specifically
   to this review. Dr Barton has received honoraria for presentations given
   from Servier, Eli Lilly, Pfizer, Solvay Pharmaceuticals, Wyeth
   Pharmaceuticals, Lundbeck and AstraZeneca. He has also received research
   funding from Pfizer and Lundbeck and provided consultancy services to
   Servier, Eli Lilly and Pfizer.
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NR 182
TC 79
Z9 96
U1 0
U2 14
PU ADIS INT LTD
PI NORTHCOTE
PA 5 THE WAREHOUSE WAY, NORTHCOTE 0627, AUCKLAND, NEW ZEALAND
SN 1172-7047
EI 1179-1934
J9 CNS DRUGS
JI CNS Drugs
PY 2009
VL 23
IS 7
BP 583
EP 602
DI 10.2165/00023210-200923070-00004
PG 20
WC Clinical Neurology; Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA 469CN
UT WOS:000267873100004
PM 19552486
DA 2025-06-11
ER

PT J
AU Bourke, CH
   Harrell, CS
   Neigh, GN
AF Bourke, Chase H.
   Harrell, Constance S.
   Neigh, Gretchen N.
TI Stress-induced sex differences: Adaptations mediated by the
   glucocorticoid receptor
SO HORMONES AND BEHAVIOR
LA English
DT Review
DE Glucocorticoid receptor; Testosterone; Progesterone; Estradiol; Sex
   differences; Obesity; Anxiety; Autoimmunity; Cytokines
ID CORTICOTROPIN-RELEASING-FACTOR; PITUITARY-ADRENAL AXIS; RAT VENTROMEDIAL
   HYPOTHALAMUS; CORONARY-HEART-DISEASE; BREAST-CANCER CELLS;
   GENDER-DIFFERENCES; PSYCHOSOCIAL STRESS; METABOLIC SYNDROME;
   IMMUNE-SYSTEM; PROINFLAMMATORY CYTOKINE
AB This article is part of a Special Issue "Neuroendocrine-Immune Axis in Health and Disease."
   Clinical evidence has indicated that women are more susceptible to stress-related and autoimmune disorders than men. Although females may be more susceptible to some disease states, males do not escape unscathed and are more susceptible to metabolic dysfunction. The hypothalamic-pituitary-axis plays a pivotal role in the sexually dimorphic effects of chronic stress through alterations in negative feedback. Recent evidence has implicated the glucocorticoid receptor and its co-chaperones in the etiology of psychiatric and somatic diseases. Gonadal hormones heavily interact with both glucocorticoid receptor expression and glucocorticoid receptor action either through direct or indirect effects on proteins in the chaperone and co-chaperone complex. Diverse systems including the hypothalamic-pituitary-axis, the immune system, and metabolism are affected differently in males and females, possibly through the glucocorticoid receptor system. New considerations of glucocorticoid regulation through the co-chaperone complex in the brain will be vital to the development of treatment strategies for men and women afflicted by neuropsychiatric and somatic disorders. (C) 2012 Elsevier Inc. All rights reserved.
C1 [Bourke, Chase H.; Harrell, Constance S.; Neigh, Gretchen N.] Emory Univ, Dept Psychiat & Behav Sci, Atlanta, GA 30322 USA.
   [Harrell, Constance S.; Neigh, Gretchen N.] Emory Univ, Dept Physiol, Atlanta, GA 30322 USA.
   [Neigh, Gretchen N.] Ctr Behav Neurosci, Atlanta, GA USA.
   [Neigh, Gretchen N.] Emory Univ, Comprehens Neurosci Ctr, Child & Adolescent Mood Program, Atlanta, GA 30322 USA.
C3 Emory University; Emory University; Emory University
RP Neigh, GN (corresponding author), 615 Michael St,Suite 600, Atlanta, GA 30322 USA.
EM gretchen.neigh@emory.edu
RI Neigh, Gretchen/AAW-5691-2020; Neigh, Gretchen/G-3662-2011
OI Harrell Shreckengost, Constance S./0000-0001-5229-0140; Neigh,
   Gretchen/0000-0003-0955-9161
FU HHMI Med into Grad Program [5600672]; NCRR Atlanta Clinical and
   Translational Science Institute [UL1 RR025008]
FX This work was made possible through the generous support of Emory
   University's Comprehensive Neuroscience Center Child and Adolescent Mood
   Program and salary support for CH Bourke was provided by the HHMI Med
   into Grad Program (Grant Number: 5600672) and the NCRR Atlanta Clinical
   and Translational Science Institute (Grant Number: UL1 RR025008).
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NR 119
TC 123
Z9 140
U1 1
U2 47
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0018-506X
EI 1095-6867
J9 HORM BEHAV
JI Horm. Behav.
PD AUG
PY 2012
VL 62
IS 3
BP 210
EP 218
DI 10.1016/j.yhbeh.2012.02.024
PG 9
WC Behavioral Sciences; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Behavioral Sciences; Endocrinology & Metabolism
GA 022GR
UT WOS:000309946300004
PM 22426413
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Gaudreault, V
   Després, JP
   Rhéaume, C
   Alméras, N
   Bergeron, J
   Tremblay, A
   Poirier, P
AF Gaudreault, Valerie
   Despres, Jean-Pierre
   Rheaume, Caroline
   Almeras, Natalie
   Bergeron, Jean
   Tremblay, Angelo
   Poirier, Paul
TI Exercise-Induced Hypertension in Men with Metabolic Syndrome:
   Anthropometric, Metabolic, and Hemodynamic Features
SO METABOLIC SYNDROME AND RELATED DISORDERS
LA English
DT Article
ID BLOOD-PRESSURE RESPONSE; CARDIOVASCULAR RISK; INSULIN-RESISTANCE;
   DISEASE; OBESE; CHOLESTEROL; PROGRAM; DENSITY; STRESS; IMPACT
AB Objective: Metabolic syndrome is associated with increased cardiac morbidity. The aim of this study was to evaluate exercise-induced hypertension (EIH) in men with metabolic syndrome and to explore potential associations with anthropometric and metabolic variables.
   Methods: A total of 179 normotensive men with metabolic syndrome underwent a maximal symptom-limited treadmill test. Blood pressure was measured at 5-min rest prior to exercise testing (anticipatory blood pressure), at every 3 min during the exercise, and during the recovery period. EIH was defined as maximum systolic blood pressure (SBP) >= 220 mmHg and/or maximum diastolic blood pressure (DBP) >= 100 mmHg.
   Results: Of the 179 men, 87 (47%) presented EIH. Resting blood pressure values at baseline were 127 +/- 10/83 +/- 6 mmHg in EIH and 119 +/- 9/80 +/- 6 mmHg (P = 0.01 for both) in normal blood pressure responders to exercise. Anticipatory SBP and DPS were higher in the group with EIH (P = 0.001). Subjects with EIH presented higher waist circumference (WC) (P < 0.01), low-density lipoprotein cholesterol (LDL-C), and apolipoprotein B (ApoB) levels as well as insulin resistance (all P < 0.05). Abdominal subcutaneous adipose tissue and total body fat mass were comparable between groups. Subjects with EIH had higher abdominal visceral adipose tissue (P < 0.001). The best predictors of EIH were resting SBP and abdominal obesity. Each increment of 5 cm in WC was associated with an odds ratio of 1.30 (1.20-1.68) for EIH.
   Conclusion: About half of our subjects with metabolic syndrome showed EIH. These men are characterized by a worsened metabolic profile. Our data suggest that a treadmill exercise test may be helpful to identify a potentially higher risk metabolic syndrome subset of subjects.
C1 [Poirier, Paul] Univ Laval, Fac Pharm, Ctr Rech, Inst Univ Cardiol & Pneumol Quebec, Ste Foy, PQ G1V 4G5, Canada.
   [Bergeron, Jean] Ctr Hosp Univ Quebec, Ctr Rech, Quebec City, PQ, Canada.
C3 Laval University; Laval University Hospital; Laval University; Laval
   University Hospital
RP Poirier, P (corresponding author), Univ Laval, Fac Pharm, Ctr Rech, Inst Univ Cardiol & Pneumol Quebec, 2725 Chemin Ste Foy, Ste Foy, PQ G1V 4G5, Canada.
EM paul.poirier@criucpq.ulaval.ca
RI Poirier, Paul/KFS-2253-2024; Rheaume, Caroline/GLS-9147-2022
OI Rheaume, Caroline/0000-0002-1863-4410
FU Institut universitaire de cardiologie et de pneumologie de Quebec
   (IUCPQ) research foundation; Canadian Diabetes Association; Canadian
   Institute of Health Research
FX This study was supported by the Institut universitaire de cardiologie et
   de pneumologie de Quebec (IUCPQ) research foundation, the Canadian
   Diabetes Association, and the Canadian Institute of Health Research. Dr.
   Paul Poirier is a senior clinical researcher of the Fonds de recherche
   en sante du Quebec (FRSQ). We would like to express our gratitude to the
   study participant for their contribution to the present study and to the
   staff for their dedicated work.
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NR 42
TC 11
Z9 12
U1 0
U2 5
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-4196
EI 1557-8518
J9 METAB SYNDR RELAT D
JI Metab. Syndr. Relat. Disord.
PD FEB
PY 2013
VL 11
IS 1
BP 7
EP 14
DI 10.1089/met.2012.0071
PG 8
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 076OF
UT WOS:000313965200003
PM 23205504
DA 2025-06-11
ER

PT J
AU Sánchez-Martínez, L
   González-Barrio, R
   García-Alonso, J
   Mena, P
   Periago, MJ
AF Sanchez-Martinez, Lorena
   Gonzalez-Barrio, Rocio
   Garcia-Alonso, Javier
   Mena, Pedro
   Periago, Maria-Jesus
TI Assessing the Impact of (Poly)phenol-Rich Foods on Cardiometabolic Risk
   in Postmenopausal Women: A Dietary Trial
SO ANTIOXIDANTS
LA English
DT Article
DE cardiovascular diseases; bioactive compounds; hypertension; metabolic
   health; women's health; dark chocolate; green tea; pomegranate; berries;
   oranges
ID GREEN TEA; MENOPAUSE; HEALTH; BIOAVAILABILITY; CONSUMPTION; GLUCOSE;
   HYPERTENSION; FLAVAN-3-OLS; POLYPHENOLS; METABOLISM
AB Menopause is a critical stage in a woman's life in which cardiometabolic alterations appear, such as insulin resistance or a predisposition to visceral fat deposits, leading to an increased risk of cardiometabolic diseases (R-CMBs). New strategies to reduce the R-CMBs in postmenopausal women using natural compounds without adverse effects are desirable. In this sense, plant-based diets rich in fruits and vegetables could play a fundamental role due to the high content of bioactive compounds found in these diets, such as (poly)phenols, known for their antioxidant, anti-inflammatory and vasodilator properties. The aim of this research was to carry out a dietary trial to evaluate the effect of the daily intake of different (poly)phenol-rich foods (PP-rich foods) for 2 months on the modulation of the main cardiometabolic risk biomarkers of postmenopausal women. The results showed a slight improvement in blood pressure (BP), lipid profile and oxidative stress, endothelial function and inflammatory biomarkers. These findings suggest that daily consumption of PP-rich foods alleviated the R-CMBs of postmenopausal women by reducing the oxidative stress and, thus, the risk of cardiovascular events; however, the magnitude of the cardioprotective effect of (poly)phenols depends on inter-individual variability.
C1 [Sanchez-Martinez, Lorena; Gonzalez-Barrio, Rocio; Garcia-Alonso, Javier; Periago, Maria-Jesus] Univ Murcia, Dept Food Technol Food Sci & Nutr, CEIR Campus Mare Nostrum,Campus Espinardo, Murcia 30100, Spain.
   [Sanchez-Martinez, Lorena; Gonzalez-Barrio, Rocio; Garcia-Alonso, Javier] Univ Clin Hosp Virgen Arrixaca, Biomed Reserach Inst Murcia IMIB Arrixaca UMU, Murcia 30120, Spain.
   [Mena, Pedro] Univ Parma, Dept Food & Drug, Via Volturno 39, I-43125 Parma, Italy.
   [Mena, Pedro] Univ Parma, Microbiome Res Hub, Parco Area Sci 11-A, I-43124 Parma, Italy.
C3 University of Murcia; Hospital Clinico Universitario Virgen de la
   Arrixaca; University of Parma; University of Parma
RP González-Barrio, R; Periago, MJ (corresponding author), Univ Murcia, Dept Food Technol Food Sci & Nutr, CEIR Campus Mare Nostrum,Campus Espinardo, Murcia 30100, Spain.; González-Barrio, R (corresponding author), Univ Clin Hosp Virgen Arrixaca, Biomed Reserach Inst Murcia IMIB Arrixaca UMU, Murcia 30120, Spain.
EM lorena.sanchez14@um.es; rgbarrio@um.es; fjgarcia@um.es;
   pedromiguel.menaparreno@unipr.it; mjperi@um.es
RI PERIAGO, MARIA JESUS/K-5251-2017; Gonzalez-Barrio, Rocio/F-2180-2018;
   Mena, Pedro/P-6353-2019
OI Gonzalez-Barrio, Rocio/0000-0002-6648-5229; PERIAGO, MARIA
   JESUS/0000-0003-2096-0167; Mena, Pedro/0000-0003-2150-2977
FU Fundacion Seneca (Agencia de Ciencia y Tecnologia de la Region de
   Murcia, Spain) [20904/PI/2018]
FX This research was funded by Fundacion Seneca (Agencia de Ciencia y
   Tecnologia de la Region de Murcia, Spain) by grant number project
   20904/PI/2018.
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NR 78
TC 1
Z9 1
U1 2
U2 5
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD AUG
PY 2024
VL 13
IS 8
AR 973
DI 10.3390/antiox13080973
PG 19
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA E8T9Q
UT WOS:001305680300001
PM 39199219
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Kadar, NNMA
   Ahmad, F
   Teoh, SL
   Yahaya, MF
AF Kadar, Nellysha Namela Muhammad Abdul
   Ahmad, Fairus
   Teoh, Seong Lin
   Yahaya, Mohamad Fairuz
TI Comparable Benefits of Stingless Bee Honey and Caffeic Acid in
   Mitigating the Negative Effects of Metabolic Syndrome on the Brain
SO ANTIOXIDANTS
LA English
DT Article
DE honey; high-carbohydrate; high-fructose diet; hippocampus; antioxidant
ID MICE
AB There is mounting evidence that metabolic syndrome (MetS) contributes to the development of neurodegenerative disorders such as Alzheimer's disease. Honey, which has been used for generations, is high in antioxidants and has been demonstrated to benefit the brain and mental health by reducing oxidative stress and boosting cognitive outcomes. Honey from the stingless bees of Heterotrigona itama has been found to have higher phenolic content compared to other types of honeys. The aim of this study is to investigate the effects of stingless bee honey (SBH) supplementation and to compare it with a pure form of antioxidant, caffeic acid (CA), on MetS parameters and inflammatory markers in the brains of MetS-induced rats. A total of 32 male Wistar rats were divided equally into groups of control, high-carbohydrate high-fructose (HCHF) diet (MetS), HCHF + SBH supplemented (1 g/kg) (SBH), and HCHF + CA supplemented (10 mg/kg) (CA) groups. The total duration for SBH and CA supplementation was eight weeks. The HCHF diet was found to promote hypertension, hyperglycemia, and hypertriglyceridemia, and to increase brain TNF-alpha levels. Supplementation with SBH and CA significantly reversed (p < 0.05) the hyperglycemic and hypertensive effects of the HCHF diet. Although both supplemented groups showed no significant changes to serum HDL or TG, SBH significantly reduced (p < 0.05) brain TNF-alpha levels and increased (p < 0.05) brain BDNF levels. Immunohistochemistry investigations of neurogenesis (EdU) and apoptosis (TUNEL) on the cornu Ammonis 1 (CA1) and dentate gyrus (DG) areas of the hippocampus showed no changes with SBH and CA supplementation compared to the control. These findings suggest that SBH and CA have the potential to mitigate HCHF-induced MetS effects and possess neuroprotective abilities.
C1 [Kadar, Nellysha Namela Muhammad Abdul; Ahmad, Fairus; Teoh, Seong Lin; Yahaya, Mohamad Fairuz] Univ Kebangsaan, Fac Med, Dept Anat, Malaysia Med Ctr, Kuala Lumpur 56000, Malaysia.
   [Kadar, Nellysha Namela Muhammad Abdul] Univ Malaysia Sabah, Fac Med & Hlth Sci, Dept Biomed Sci & Therapeut, Kota Kinabalu 88400, Sabah, Malaysia.
C3 Universiti Kebangsaan Malaysia; Universiti Malaysia Sabah
RP Yahaya, MF (corresponding author), Univ Kebangsaan, Fac Med, Dept Anat, Malaysia Med Ctr, Kuala Lumpur 56000, Malaysia.
EM mfairuzy@ukm.edu.my
RI Teoh, Seong/P-3950-2017; Yahaya, Mohamad/K-7614-2019
OI Yahaya, Mohamad Fairuz/0000-0001-7155-2636; Ahmad,
   Fairus/0000-0002-2452-6459
FU Faculty of Medicine, Universiti Kebangsaan Malaysia [FF-2019-014]
FX This research was funded by Faculty of Medicine, Universiti Kebangsaan
   Malaysia, grant number FF-2019-014.
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NR 69
TC 12
Z9 12
U1 1
U2 5
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD NOV
PY 2022
VL 11
IS 11
AR 2154
DI 10.3390/antiox11112154
PG 16
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA 6D2ZV
UT WOS:000882566100001
PM 36358526
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Wallwork, RS
   Colicino, E
   Zhong, J
   Kloog, I
   Coull, BA
   Vokonas, P
   Schwartz, JD
   Baccarelli, AA
AF Wallwork, Rachel S.
   Colicino, Elena
   Zhong, Jia
   Kloog, Itai
   Coull, Brent A.
   Vokonas, Pantel
   Schwartz, Joel D.
   Baccarelli, Andrea A.
TI Ambient Fine Particulate Matter, Outdoor Temperature, and Risk of
   Metabolic Syndrome
SO AMERICAN JOURNAL OF EPIDEMIOLOGY
LA English
DT Article
DE air pollution; blood glucose; high-density lipoprotein cholesterol;
   hypertension; metabolic syndrome; obesity; temperature; triglycerides
ID BODY-FAT DISTRIBUTION; BROWN ADIPOSE-TISSUE; AIR-POLLUTION; OXIDATIVE
   STRESS; NHANES-III; PREVALENCE; OBESITY; MORTALITY; EXPOSURE;
   HYPERTENSION
AB Ambient air pollution and temperature have been linked with cardiovascular morbidity and mortality. Metabolic syndrome and its components-abdominal obesity, elevated fasting blood glucose concentration, low highdensity lipoprotein cholesterol concentration, hypertension, and hypertriglyceridemia-predict cardiovascular disease, but the environmental causes are understudied. In this study, we prospectively examined the long-term associations of air pollution, defined as particulate matter with an aerodynamic diameter less than or equal to 2.5 mu m (PM2.5), and temperature with the development of metabolic syndrome and its components. Using covariate-adjustment Cox proportional hazards models, we estimated associations of mean annual PM2.5 concentration and temperature with risk of incident metabolic dysfunctions between 1993 and 2011 in 587 elderly (mean = 70 (standard deviation, 7) years of age) male participants in the Normative Aging Study. A 1-mu g/m3 increase in mean annual PM2.5 concentration was associated with a higher risk of developing metabolic syndrome (hazard ratio (HR) = 1.27, 95% confidence interval (CI): 1.06, 1.52), an elevated fasting blood glucose level (HR = 1.20, 95% CI: 1.03, 1.39), and hypertriglyceridemia (HR = 1.14, 95% CI: 1.00, 1.30). Our findings for metabolic syndrome and high fasting blood glucose remained significant for PM2.5 levels below the Environmental Protection Agency's health-safety limit (12 mu g/m3). A 1 degrees C increase in mean annual temperature was associated with a higher risk of developing elevated fasting blood glucose (HR = 1.33, 95% CI: 1.14, 1.56). Men living in neighborhoods with worse air quality-with higher PM2.5 levels and/or temperatures than average-showed increased risk of developing metabolic dysfunctions.
C1 [Colicino, Elena] Columbia Univ, Mailman Sch Publ Hlth, Dept Environm Hlth Sci, Bldg P&S 16-416,722 W 168th St, New York, NY 10032 USA.
   [Wallwork, Rachel S.] Harvard Univ, Harvard Med Sch, Dept Environm Hlth, Boston, MA 02115 USA.
   [Colicino, Elena; Zhong, Jia; Coull, Brent A.; Schwartz, Joel D.; Baccarelli, Andrea A.] Harvard Univ, Harvard TH Chan Sch Publ Hlth, Dept Environm Hlth, Boston, MA 02115 USA.
   [Kloog, Itai] Ben Gurion Univ Negev, Fac Humanities & Social Sci, Dept Geog & Environm Dev, Beer Sheva, Israel.
   [Vokonas, Pantel] VA Boston Healthcare Syst, Dept Epidemiol, Boston, MA USA.
   [Vokonas, Pantel] Boston Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA USA.
   [Vokonas, Pantel] Boston Univ, Sch Med, Dept Med, Boston, MA 02118 USA.
C3 Columbia University; Harvard University; Harvard Medical School; Harvard
   University; Harvard T.H. Chan School of Public Health; Ben-Gurion
   University of the Negev; Harvard University; Harvard University Medical
   Affiliates; US Department of Veterans Affairs; Veterans Health
   Administration (VHA); VA Boston Healthcare System; Boston University;
   Boston University
RP Colicino, E (corresponding author), Columbia Univ, Mailman Sch Publ Hlth, Dept Environm Hlth Sci, Bldg P&S 16-416,722 W 168th St, New York, NY 10032 USA.
EM elena.colicino@columbia.edu
RI Colicino, Elena/Q-4973-2016
OI Colicino, Elena/0000-0002-1875-8448; Wallwork,
   Rachel/0000-0002-0073-7438
FU National Institute of Environmental Health Sciences [R01ES021733,
   R01ES015172]; Cooperative Studies Program, Massachusetts Veterans
   Epidemiology Research and Information Center; US Department of
   Agriculture, Agricultural Research Service [53-K06-510]
FX This work was supported by the National Institute of Environmental
   Health Sciences (grants R01ES021733 and R01ES015172). The Normative
   Aging Study (NAS) is supported by the Cooperative Studies Program,
   Massachusetts Veterans Epidemiology Research and Information Center.
   Additional support for the NAS was provided by the US Department of
   Agriculture, Agricultural Research Service (contract 53-K06-510).
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NR 48
TC 123
Z9 132
U1 1
U2 56
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0002-9262
EI 1476-6256
J9 AM J EPIDEMIOL
JI Am. J. Epidemiol.
PD JAN 1
PY 2017
VL 185
IS 1
BP 30
EP 39
DI 10.1093/aje/kww157
PG 10
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA EP2RY
UT WOS:000397232100005
PM 27927620
OA Green Published, Green Submitted, Bronze
DA 2025-06-11
ER

PT J
AU Vuguin, PM
   Hartil, K
   Kruse, M
   Kaur, H
   Lin, CLV
   Fiallo, A
   Glenn, AS
   Patel, A
   Williams, L
   Seki, Y
   Katz, EB
   Charron, MJ
AF Vuguin, Patricia M.
   Hartil, Kirsten
   Kruse, Michael
   Kaur, Harpreet
   Lin, Chia-Lei Vivian
   Fiallo, Ariana
   Glenn, Alan Scott
   Patel, Avanee
   Williams, Lyda
   Seki, Yoshinori
   Katz, Ellen B.
   Charron, Maureen J.
TI Shared Effects of Genetic and Intrauterine and Perinatal Environment on
   the Development of Metabolic Syndrome
SO PLOS ONE
LA English
DT Article
ID HIGH-FAT DIET; FOR-GESTATIONAL-AGE; HEPATIC INSULIN-RESISTANCE;
   ADIPOSE-TISSUE; PHOSPHOENOLPYRUVATE CARBOXYKINASE; SKELETAL-MUSCLE;
   KNOCKOUT MICE; FETAL-GROWTH; PREDICTS OBESITY; LIPID-METABOLISM
AB Genetic and environmental factors, including the in utero environment, contribute to Metabolic Syndrome. Exposure to high fat diet exposure in utero and lactation increases incidence of Metabolic Syndrome in offspring. Using GLUT4 heterozygous (G4+/-) mice, genetically predisposed to Type 2 Diabetes Mellitus, and wild-type littermates we demonstrate genotype specific differences to high fat in utero and lactation. High fat in utero and lactation increased adiposity and impaired insulin and glucose tolerance in both genotypes. High fat wild type offspring had increased serum glucose and PAI-1 levels and decreased adiponectin at 6 wks of age compared to control wild type. High fat G4+/- offspring had increased systolic blood pressure at 13 wks of age compared to all other groups. Potential fetal origins of adult Metabolic Syndrome were investigated. Regardless of genotype, high fat in utero decreased fetal weight and crown rump length at embryonic day 18.5 compared to control. Hepatic expression of genes involved in glycolysis, gluconeogenesis, oxidative stress and inflammation were increased with high fat in utero. Fetal serum glucose levels were decreased in high fat G4+/- compared to high fat wild type fetuses. High fat G4+/-, but not high fat wild type fetuses, had increased levels of serum cytokines (IFN-gamma, MCP-1, RANTES and M-CSF) compared to control. This data demonstrates that high fat during pregnancy and lactation increases Metabolic Syndrome male offspring and that heterozygous deletion of GLUT4 augments susceptibility to increased systolic blood pressure. Fetal adaptations to high fat in utero that may predispose to Metabolic Syndrome in adulthood include changes in fetal hepatic gene expression and alterations in circulating cytokines. These results suggest that the interaction between in utero-perinatal environment and genotype plays a critical role in the developmental origin of health and disease.
C1 [Vuguin, Patricia M.; Kaur, Harpreet] Childrens Hosp Montefiore, Div Pediat Endocrinol, Bronx, NY USA.
   [Kaur, Harpreet] Childrens Hosp Montefiore, Div Neonatol, Bronx, NY USA.
   [Hartil, Kirsten; Kruse, Michael; Lin, Chia-Lei Vivian; Fiallo, Ariana; Glenn, Alan Scott; Patel, Avanee; Williams, Lyda; Seki, Yoshinori; Katz, Ellen B.; Charron, Maureen J.] Albert Einstein Coll Med, Dept Biochem, Bronx, NY 10467 USA.
   [Charron, Maureen J.] Montefiore Med Ctr, Albert Einstein Coll Med, Dept Med, Bronx, NY 10467 USA.
   [Charron, Maureen J.] Yeshiva Univ Albert Einstein Coll Med, Dept Obstet & Gynecol, Bronx, NY 10461 USA.
C3 Montefiore Medical Center; Albert Einstein College of Medicine;
   Childrens Hospital at Montefiore; Montefiore Medical Center; Albert
   Einstein College of Medicine; Childrens Hospital at Montefiore; Yeshiva
   University; Montefiore Medical Center; Albert Einstein College of
   Medicine; Yeshiva University; Montefiore Medical Center; Albert Einstein
   College of Medicine; Montefiore Medical Center; Albert Einstein College
   of Medicine; Yeshiva University
RP Vuguin, PM (corresponding author), Childrens Hosp Montefiore, Div Pediat Endocrinol, Bronx, NY USA.
EM pvuguin@nshs.edu; charron@einstein.yu.edu
RI Kaur, Harpreet/HTN-0358-2023
OI Lin, Chia-Lei/0000-0002-8729-320X; vuguin, patricia/0000-0002-4982-0400
FU National Institutes of Health [DK47435, HL58119, K08-HD042172,
   F31-DK093332]; ADA Mentor based postdoctoral fellowship
FX This study was supported by grants from the National Institutes of
   Health DK47435 and HL58119 (MJC) and K08-HD042172 (PV) and F31-DK093332
   (LW), and an ADA Mentor based postdoctoral fellowship (MJC). Additional
   support was generously provided by the Diabetes Research and Training,
   Liver, and Cancer Centers of Albert Einstein College of Medicine. The
   funders had no role in study design, data collection and analysis,
   decision to publish, or preparation of the manuscript.
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NR 76
TC 29
Z9 31
U1 0
U2 17
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAY 17
PY 2013
VL 8
IS 5
AR e63021
DI 10.1371/journal.pone.0063021
PG 10
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 146RJ
UT WOS:000319107900021
PM 23690974
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Arredondo, EM
   Lemus, H
   Elder, JP
   Molina, M
   Martinez, S
   Sumek, C
   Ayala, GX
AF Arredondo, Elva M.
   Lemus, Hector
   Elder, John P.
   Molina, Marisa
   Martinez, Suzanna
   Sumek, Caryn
   Ayala, Guadalupe X.
TI The relationship between sedentary behavior and depression among Latinos
SO MENTAL HEALTH AND PHYSICAL ACTIVITY
LA English
DT Article
DE Sedentary behavior; Depression; Latinos; Risk factors
ID PHYSICAL-ACTIVITY; SOCIOECONOMIC-STATUS; METABOLIC SYNDROME;
   NATIONAL-HEALTH; SOCIAL-STATUS; TIME; OBESITY; ADULTS; TELEVISION;
   INACTIVITY
AB Introduction: Sedentary behavior is a risk factor for depression, yet there is little known about the factors that moderate this relationship. The primary goals of the study were to examine: 1) the association between depression severity and sedentary behavior, weight status, and social integration, and 2) the moderating role of socio-demographic characteristics, and social integration, and perceived social mobility on the association between depression and sedentary behaviors.
   Methods: Three hundred and ninety-seven adults were recruited using multistage sampling methods and consented to complete a one-time interview and measurement of height and weight. The mean age was 43.4 +/- 16.9, and 47% were obese.
   Results: Findings suggest that depression was positively associated with sedentary behaviors. Moreover, age and perceived social mobility moderated the relationship between depression and sedentary behavior.
   Conclusions: Our findings suggest that there are sedentary individuals at highest risk for developing depression. Sedentary individuals who were older or reported a lower social status were at highest risk for depression. Identifying these individuals in intervention programs that aim to reduce sedentary behavior and depression may enhance the effectiveness of these programs. (C) 2012 Elsevier Ltd. All rights reserved.
C1 [Arredondo, Elva M.; Ayala, Guadalupe X.] San Diego State Univ, Grad Sch Publ Hlth, Div Hlth Promot, San Diego, CA 92123 USA.
   [Arredondo, Elva M.; Elder, John P.; Molina, Marisa; Ayala, Guadalupe X.] San Diego State Univ, San Diego Prevent Res Ctr, San Diego, CA 92123 USA.
   [Lemus, Hector] San Diego State Univ, Grad Sch Publ Hlth, Div Biostat, San Diego, CA 92182 USA.
   [Elder, John P.] San Diego State Univ, Div Hlth Promot, San Diego, CA 92123 USA.
   [Martinez, Suzanna] Univ Calif San Diego, Dept Pediat, La Jolla, CA 92093 USA.
   [Sumek, Caryn] San Ysidro Hlth Ctr, San Ysidro, CA USA.
C3 California State University System; San Diego State University;
   California State University System; San Diego State University;
   California State University System; San Diego State University;
   California State University System; San Diego State University;
   University of California System; University of California San Diego
RP Arredondo, EM (corresponding author), San Diego State Univ, Grad Sch Publ Hlth, Div Hlth Promot, 9245 Sky Pk Ct,Suite 221, San Diego, CA 92123 USA.
EM earredondo@projects.sdsu.edu; hlemus@mail.sdsu.edu;
   jelder@projects.sdsu.edu; mmolina@projects.sdsu.edu; smmartin@ucsd.edu;
   csumek@syhc.org; ayala@mail.sdsu.edu
OI Martinez, Suzanna/0000-0001-7864-1391
FU Centers for Disease Control and Prevention [U48 DP00036-04]
FX This research was funded by the Centers for Disease Control and
   Prevention, U48 DP00036-04.
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NR 48
TC 18
Z9 25
U1 2
U2 16
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1755-2966
J9 MENT HEALTH PHYS ACT
JI Ment. Health Phys. Act.
PD MAR
PY 2013
VL 6
IS 1
SI SI
BP 3
EP 9
DI 10.1016/j.mhpa.2012.10.005
PG 7
WC Psychology, Clinical; Psychiatry
WE Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA V36SG
UT WOS:000209230400002
DA 2025-06-11
ER

PT J
AU Macdonald, CS
   Bennekou, MA
   Nielsen, SM
   Junker, AE
   Biering-Sorensen, T
   Langberg, H
   Christensen, R
   Lieberman, DE
   Zachariae, C
   Pallisgaard, JL
AF Macdonald, Christopher Scott
   Bennekou, Mia Aagaard
   Nielsen, Sabrina Mai
   Junker, Anders Ellekaer
   Biering-Sorensen, Tor
   Langberg, Henning
   Christensen, Robin
   Lieberman, Daniel E.
   Zachariae, Claus
   Pallisgaard, Jannik Langtved
TI Evolutionary Mismatch and Lifestyle-Related Diseases: A Study of a
   6-Month Intensive Lifestyle Intervention
SO SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
LA English
DT Article
DE diabetes; evolutionary mismatch; exercise; lifestyle; metabolic
   syndrome; nutrition; physical activity
ID TYPE-2 DIABETES-MELLITUS; CARDIOVASCULAR RISK-FACTORS; ALL-CAUSE
   MORTALITY; PHYSICAL-ACTIVITY; GLYCEMIC CONTROL; METABOLIC SYNDROME;
   WEIGHT-LOSS; EXERCISE; METAANALYSIS; INDIVIDUALS
AB Chronic medical conditions caused by the inadequate adaptation of the body to modern lifestyles, such as physical inactivity and unhealthy diets, are on the rise. This study assessed whether a comprehensive lifestyle intervention, including high volumes of supervised exercise, could improve health outcomes. Eight volunteers with lifestyle-related diseases received a 6-month lifestyle intervention consisting of 8000-10 000 steps/day, 6 moderate-intensity endurance and 3 resistance training sessions per week, a 5-week long hike, and dietary advice. This was followed by 7 months of limited remote supervision, ending 13 months from baseline. The participants (3 females, 5 males; mean age 42.9 years) had conditions including type 2 diabetes (T2D), depression/stress, and metabolic syndrome (MS). After 6 months, body weight decreased significantly by 23 kg (95% CI; -33.7 to -12.2), with a minor non-significant decrease in lean body mass of 1.96 kg (95% CI; -4.34 to 0.27). Maximal oxygen consumption (VO2max) increased by 18.5 mL/O2/kg/min. (95% CI; 13.8-23.1) and systolic and diastolic blood pressures decreased by 33 (95% CI; -39 to -26) and 18 mmHg (95% CI; -23 to -14), respectively. Three of the 4 participants with T2D had normalized glycated hemoglobin (HbA1c) levels, and all showed improved 2-h oral glucose tolerance (OGTT) without pharmacological treatment. Participants with T2D continued to lower HbA1c during the 7-month follow-up period. This 6-month lifestyle intervention restored metabolic health and improved cardiovascular health in 8 participants with lifestyle-related diseases while reducing the need for pharmacological treatments. These findings suggest that comprehensive lifestyle changes can reverse several medical conditions caused by evolutionary mismatch.
C1 [Macdonald, Christopher Scott] Univ Copenhagen, Ctr Inflammat & Metab, Rigshosp, Copenhagen, Denmark.
   [Macdonald, Christopher Scott] Univ Copenhagen, Ctr Phys Act Res, Rigshosp, Copenhagen, Denmark.
   [Macdonald, Christopher Scott; Nielsen, Sabrina Mai; Christensen, Robin] Bispebjerg & Frederiksberg Hosp, Parker Inst, Sect Biostat & Evidence Based Res, Copenhagen, Denmark.
   [Bennekou, Mia Aagaard] Grace Hlth & Performance Enhancement, Horsholm, Denmark.
   [Nielsen, Sabrina Mai; Christensen, Robin] Univ Southern Denmark, Odense Univ Hosp, Dept Clin Res, Res Unit Rheumatol, Odense, Denmark.
   [Junker, Anders Ellekaer] Univ Hosp Hvidovre, Gastro Unit, Copenhagen, Denmark.
   [Biering-Sorensen, Tor] Univ Copenhagen, Fac Hlth & Med Sci, Ctr Translat Cardiol & Pragmat Randomized Trials, Dept Biomed Sci, Copenhagen, Denmark.
   [Biering-Sorensen, Tor] Copenhagen Univ Hosp Herlev & Gentofte, Dept Cardiol, Cardiovasc Noninvas Imaging Res Lab, Copenhagen, Denmark.
   [Biering-Sorensen, Tor] Steno Diabet Ctr Copenhagen, Copenhagen, Denmark.
   [Biering-Sorensen, Tor] Copenhagen Univ Hosp, Rigshosp, Dept Cardiol, Copenhagen, Denmark.
   [Langberg, Henning] Univ Copenhagen, Dept Publ Hlth, Copenhagen, Denmark.
   [Lieberman, Daniel E.] Harvard Univ, Dept Human Evolutionary Biol, Cambridge, MA USA.
   [Zachariae, Claus] Herlev & Gentofte Hosp, Dept Dermatol & Allergy, Copenhagen, Denmark.
   [Pallisgaard, Jannik Langtved] JP Cardiol, Copenhagen, Denmark.
C3 Rigshospitalet; University of Copenhagen; Copenhagen University
   Hospital; Rigshospitalet; University of Copenhagen; Copenhagen
   University Hospital; University of Copenhagen; Bispebjerg Hospital;
   University of Southern Denmark; Odense University Hospital; University
   of Copenhagen; University of Copenhagen; Steno Diabetes Center;
   University of Copenhagen; Copenhagen University Hospital;
   Rigshospitalet; University of Copenhagen; Harvard University
RP Macdonald, CS (corresponding author), Univ Copenhagen, Ctr Inflammat & Metab, Rigshosp, Copenhagen, Denmark.; Macdonald, CS (corresponding author), Univ Copenhagen, Ctr Phys Act Res, Rigshosp, Copenhagen, Denmark.; Macdonald, CS (corresponding author), Bispebjerg & Frederiksberg Hosp, Parker Inst, Sect Biostat & Evidence Based Res, Copenhagen, Denmark.
EM chmd@sund.ku.dk
RI Biering-Sørensen, Tor/G-9465-2013; Pallisgaard, Jannik/S-9546-2019;
   Zachariae, Claus/G-6144-2018
OI Pallisgaard, Jannik Langtved/0000-0002-8072-3318; Langberg,
   Henning/0000-0001-8454-6534; Christensen, Robin/0000-0002-6600-0631;
   Nielsen, Sabrina Mai/0000-0003-2857-2484; Zachariae,
   Claus/0000-0001-5506-1319
FU TrygFonden; Oak Foundation (OCAY-18-774-OFIL)
FX We are indebted to the participants in this study. In addition, Stine
   Kirkegaard Pehm & oslash;ller aided by conducting Beck Depression
   Inventory scores. This study was funded by the TrygFonden. The funder
   supported it financially; otherwise, it had no role or competing
   interest. Section for Biostatistics and Evidence-Based Research, the
   Parker Institute is supported by a core grant from The Oak Foundation
   (OCAY-18-774-OFIL), a group of philanthropic organizations giving grants
   to not-for-profit organizations around the world.
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NR 69
TC 0
Z9 0
U1 2
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0905-7188
EI 1600-0838
J9 SCAND J MED SCI SPOR
JI Scand. J. Med. Sci. Sports
PD DEC
PY 2024
VL 34
IS 12
AR e14770
DI 10.1111/sms.14770
PG 20
WC Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Sport Sciences
GA P7J7D
UT WOS:001379630100001
PM 39695354
DA 2025-06-11
ER

PT J
AU Greenman, PS
   Renzi, A
   Monaco, S
   Luciani, F
   Di Trani, M
AF Greenman, Paul Samuel
   Renzi, Alessia
   Monaco, Silvia
   Luciani, Francesca
   Di Trani, Michela
TI How Does Trauma Make You Sick? The Role of Attachment in Explaining
   Somatic Symptoms of Survivors of Childhood Trauma
SO HEALTHCARE
LA English
DT Review
DE childhood trauma; attachment; somatic symptomatology; review
ID QUALITY-OF-LIFE; ADULT ATTACHMENT; NONEPILEPTIC SEIZURES; INSECURE
   ATTACHMENT; COMPLEX TRAUMA; EXPERIENCES; LONELINESS; INTERVIEW; ABUSE;
   VULNERABILITY
AB Exposure to traumatic events during childhood is common, and the consequences for physical and mental health can be severe. Adverse childhood experiences (ACEs) such as physical abuse, sexual abuse, emotional abuse, and neglect appear to contribute to the onset and severity of a variety of somatic inflictions, including obesity, diabetes, cancer, and heart disease. The aim of this scoping review was to try to gain insight into how this might occur. Given the evidence of indirect (i.e., through unhealthy behaviours such as excessive drinking or poor eating habits) and direct (i.e., through its impact on the endocrine, immune, and cardiovascular systems as well as on the brain) effects of attachment on health, we examined the possibility that insecure attachment might contribute to the development of somatic symptoms in adult survivors of childhood trauma. Eleven studies met our inclusion criteria. Findings from this review suggest that insecure and disorganized attachment orientations are related to DNA damage, metabolic syndrome and obesity, physical pain, functional neurological disorder, and somatization in adults exposed to childhood trauma. We discuss the implications of this for the conceptualization and treatment of trauma and stress disorders.
C1 [Greenman, Paul Samuel] Univ Quebec Outaouais, Dept Psychoeduc & Psychol, Gatineau, PQ J8X 3X7, Canada.
   [Greenman, Paul Samuel] Inst Savoir Montfort, Ottawa, ON K1K 0T2, Canada.
   [Renzi, Alessia; Monaco, Silvia; Luciani, Francesca; Di Trani, Michela] Sapienza Univ Rome, Dept Dynam & Clin Psychol & Hlth Studies, I-00185 Rome, Italy.
C3 University of Quebec; University Quebec Outaouais; Sapienza University
   Rome
RP Renzi, A (corresponding author), Sapienza Univ Rome, Dept Dynam & Clin Psychol & Hlth Studies, I-00185 Rome, Italy.
EM paul.greenman@uqo.ca; alessia.renzi@uniroma1.it;
   silvia.monaco@uniroma1.it; luciani.1799082@studenti.uniroma1.it;
   michela.ditrani@uniroma1.it
OI RENZI, ALESSIA/0000-0002-8553-4444; Monaco, Silvia/0000-0001-6838-7537;
   DI TRANI, MICHELA/0000-0002-5085-3453
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NR 72
TC 3
Z9 3
U1 12
U2 46
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2227-9032
J9 HEALTHCARE-BASEL
JI Healthcare
PD JAN
PY 2024
VL 12
IS 2
AR 203
DI 10.3390/healthcare12020203
PG 16
WC Health Care Sciences & Services; Health Policy & Services
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services
GA FY3G2
UT WOS:001149367400001
PM 38255090
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Gleason, JL
   Shenassa, ED
   Thoma, ME
AF Gleason, Jessica L.
   Shenassa, Edmond D.
   Thoma, Marie E.
TI Self-reported infertility, metabolic dysfunction, and cardiovascular
   events: a cross-sectional analysis among US women
SO FERTILITY AND STERILITY
LA English
DT Article
DE Infertility; cardiovascular disease; reproductive health
ID POLYCYSTIC-OVARY-SYNDROME; UNITED-STATES; RISK; PREVALENCE; DIAGNOSIS;
   STRESS; DISEASE; SYSTEM
AB Objective: To explore associations between infertility and metabolic syndrome, and cardiovascular events. Infertility is increasingly a public health issue, with emerging links to chronic disease. Existing literature on infertility focuses primarily on known causes, which likely excludes a substantial number of women for whom there is no known cause or formal diagnosis.
   Design/Setting: We conducted a cross-sectional analysis examining the association between self-reported infertility (i.e., ever experiencing inability to conceive after 12 months of trying to become pregnant) and metabolic syndrome and cardiovascular events (i.e., congestive heart failure, coronary heart disease, heart attack, or stroke). Data were analyzed using multivariate logistic regression.
   Patient(s): A total of 744 U.S. women, 20-59 years of age, from the National Health and Nutrition Examination Survey (2013-2014), participated in the study. Among them, 15.7% reported ever experiencing infertility, 27.6% met the definition of metabolic syndrome, and 2.84% reported ever having a cardiovascular event.
   Intervention(s): N/A.
   Main Outcome Measure(s): Metabolic syndrome and cardiovascular events.
   Results: Compared to women who had never experienced infertility, women who reported infertility had a 1.79 (95% confidence interval [CI] 1.04, 3.08) higher odds of reporting symptoms of metabolic syndrome and 1.83 (95% CI 1.15, 2.89) times higher odds of having experienced a cardiovascular event. Furthermore, women with self-reported infertility had a 71% higher odds of reporting a cardiovascular event after controlling for metabolic syndrome (95% CI 1.01, 3.00).
   Conclusions: Our results suggest that among U.S. women, the experience of infertility at any point in a woman's reproductive window may be associated with later-life cardiovascular health. (C) 2018 by American Society for Reproductive Medicine.
C1 [Gleason, Jessica L.; Shenassa, Edmond D.; Thoma, Marie E.] Univ Maryland, Maternal & Child Hlth Program, Dept Family Sci, Sch Publ Hlth, 4200 Valley Dr,Suite 1142, College Pk, MD 20742 USA.
   [Shenassa, Edmond D.] Univ Maryland, Dept Epidemiol & Biostat, Sch Publ Hlth, College Pk, MD 20742 USA.
   [Shenassa, Edmond D.] Brown Univ, Dept Epidemiol, Sch Publ Hlth, Providence, RI 02912 USA.
   [Shenassa, Edmond D.] Univ Maryland, Sch Med, Dept Epidemiol & Publ Hlth, Baltimore, MD 21201 USA.
C3 University System of Maryland; University of Maryland College Park;
   University System of Maryland; University of Maryland College Park;
   Brown University; University System of Maryland; University of Maryland
   Baltimore
RP Gleason, JL (corresponding author), Univ Maryland, Maternal & Child Hlth Program, Dept Family Sci, Sch Publ Hlth, 4200 Valley Dr,Suite 1142, College Pk, MD 20742 USA.
EM jgleason@umd.edu
RI Gleason, Jessica/AAL-3947-2021
OI Gleason, Jessica/0000-0001-9877-7931; Shenassa,
   Edmond/0000-0001-6244-5847
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NR 40
TC 49
Z9 50
U1 0
U2 5
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0015-0282
EI 1556-5653
J9 FERTIL STERIL
JI Fertil. Steril.
PD JAN
PY 2019
VL 111
IS 1
BP 138
EP 146
DI 10.1016/j.fertnstert.2018.10.009
PG 9
WC Obstetrics & Gynecology; Reproductive Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology; Reproductive Biology
GA HG1KC
UT WOS:000454711800026
PM 30458992
OA Bronze
DA 2025-06-11
ER

PT J
AU McDade, TW
   Hoke, M
   Borja, JB
   Adair, LS
   Kuzawa, C
AF McDade, Thomas W.
   Hoke, Morgan
   Borja, Judith B.
   Adair, Linda S.
   Kuzawa, Christopher
TI Do environments in infancy moderate the association between stress and
   inflammation in adulthood? Initial evidence from a birth cohort in the
   Philippines
SO BRAIN BEHAVIOR AND IMMUNITY
LA English
DT Article
DE Inflammation; High sensitivity C-reactive protein;
   Psychoneuroimmunology; Infectious disease; Cardiovascular disease;
   Developmental origins of adult disease; Human ecological immunology
ID C-REACTIVE PROTEIN; LIFE-HISTORY; CARDIOVASCULAR-DISEASE; ELEVATED
   INTERLEUKIN-6; PSYCHOLOGICAL STRESS; SOCIOECONOMIC-STATUS; METABOLIC
   SYNDROME; EARLY ORIGINS; YOUNG-ADULTS; HEALTH
AB Chronic inflammation is a potentially important pathway through which psychosocial stressors increase risk for cardiovascular disease. However, prior research on stress and inflammation has been conducted almost exclusively in high income, industrialized populations with low levels of infectious disease. In this study we test the hypothesis that psychosocial stressors are associated with elevated concentrations of C-reactive protein (CRP) among young adults in the Philippines (n = 1622), who have grown up in an ecological and epidemiological setting that differs substantially from that of the US. In addition, we apply a developmental, ecological perspective to consider whether microbial and nutritional environments in infancy alter patterns of association between stressors and CRP. Data come from the Cebu Longitudinal Health and Nutrition Survey, a prospective cohort study that began collecting data in 1983-1984 when participants were in utero. A series of regression models indicate trends toward significant interactions between perceived stress and environmental factors in infancy, including exposure to animal feces, season of birth, and birth weight. Parental absence in childhood was a significant predictor of CRP in adulthood in interaction with exposure to animal feces in infancy. Positive associations between stressors and CRP were only evident for individuals with lower levels of microbial exposure in infancy, or lower birth weight. These results suggest that early environments influence the development of inflammatory phenotypes in ways that moderate sensitivity to psychosocial stressors in adulthood, and they underscore the value of a comparative, developmental approach to research on social environments, inflammation, and disease. (c) 2012 Elsevier Inc. All rights reserved.
C1 [McDade, Thomas W.; Hoke, Morgan; Kuzawa, Christopher] Northwestern Univ, Dept Anthropol, Evanston, IL 60208 USA.
   [McDade, Thomas W.; Kuzawa, Christopher] Northwestern Univ, Inst Policy Res, Ctr Social Dispar & Hlth, Cells Soc C2S, Evanston, IL 60208 USA.
   [Borja, Judith B.] Univ San Carlos, Off Populat Studies Fdn, Cebu, Philippines.
   [Adair, Linda S.] Univ N Carolina, Carolina Populat Ctr, Chapel Hill, NC USA.
   [Adair, Linda S.] Univ N Carolina, Dept Nutr, Chapel Hill, NC USA.
C3 Northwestern University; Northwestern University; University of San
   Carlos; University of North Carolina; University of North Carolina
   Chapel Hill; University of North Carolina; University of North Carolina
   Chapel Hill
RP McDade, TW (corresponding author), Northwestern Univ, Dept Anthropol, 1810 Hinman Ave, Evanston, IL 60208 USA.
EM t-mcdade@northwestern.edu
FU National Institutes of Health [RO1HL085144, 5RO1TW05596]; Fogarty
   International Center [5RO3TW008133]; Interdisciplinary Obesity Center
   [RR20649]; Center for Environmental Health and Susceptibility [ES10126,
   7-2004-E]
FX Funding for this study was provided by Grants from the National
   Institutes of Health (RO1HL085144; 5RO1TW05596), including the Fogarty
   International Center (5RO3TW008133); biomarker data collection was
   supported by pilot funds from the Interdisciplinary Obesity Center
   (RR20649) and the Center for Environmental Health and Susceptibility
   (ES10126; Project 7-2004-E).
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NR 67
TC 65
Z9 79
U1 0
U2 34
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0889-1591
EI 1090-2139
J9 BRAIN BEHAV IMMUN
JI Brain Behav. Immun.
PD JUL
PY 2013
VL 31
SI SI
BP 23
EP 30
DI 10.1016/j.bbi.2012.08.010
PG 8
WC Immunology; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Immunology; Neurosciences & Neurology; Psychiatry
GA 158YM
UT WOS:000320011100003
PM 22960631
OA Green Accepted, Green Published
DA 2025-06-11
ER

PT J
AU Dragovic, G
   Andjic, M
   Toljic, B
   Jevtovic, D
   Lukic, R
   de Luka, S
   Trbovich, A
   Milasin, J
AF Dragovic, Gordana
   Andjic, Mladen
   Toljic, Bosko
   Jevtovic, Djordje
   Lukic, Relja
   de Luka, Silvio
   Trbovich, Alexander
   Milasin, Jelena
TI Correlation between metabolic syndrome and relative telomere length
   shortening in HIV/AIDS patients on combined antiretroviral therapy
SO EXPERIMENTAL GERONTOLOGY
LA English
DT Article
DE Relative telomere length; Metabolic syndrome; HIV-infected men on cART
ID HIV-INFECTED PATIENTS; OXIDATIVE STRESS; ASSOCIATION; DNA; INDIVIDUALS;
   PREVALENCE; GUIDELINES; NAIVE; RISK
AB Background: Components of the metabolic syndrome (MetS) play an important role in the accelerated aging process. Relative telomere length (RTL) is a marker of biological aging. The aim of our study was to determine RTL and its possible association with MetS and the components of MetS in HIV-infected patients treated with cART.
   Methods: We included 24 HIV-infected men, all Caucasians, with successful cART (<50 HIV-RNA copies/mL) and on stable cART for at least 24 months. The presence of MetS and its components was determined by the criteria prescribed by the International Diabetes Federation. RTL was determined by Real-Time PCR and Delta Delta Ct method. We performed a multiple linear regression modeling on log-transformed RTL (dependant variable) to evaluate which components of the metabolic syndrome as well as cART duration and cART type, had an impact on RTL.
   Results: Eleven (45.8%) patients had and 13 (54.2%) had not MetS. All patients, had an undetectable viral RNA and a relatively good immune status. The mean RTL was 0.62 +/- 0.15 and 0.95 +/- 0.36 in patients with and without MetS, respectively (p = 0.01). Multiple linear regression model showed no significant association between duration of cART, cART type and RTL (p = 0.2165, p = 0.8628, respectively). The same analysis showed that an increase in number of MetS components was associated with shorter telomere length (beta = -0.4982, p = 0.042).
   Conclusions: We showed for the first time association between RTL shortening in HIV-infected men with metabolic syndrome. Furthermore, our study also indicated that an increment of metabolic syndrome components is strongly associated with shorter telomere length.
C1 [Dragovic, Gordana; Andjic, Mladen] Univ Belgrade, Sch Med, Dept Pharmacol Clin Pharmacol & Toxicol, Dr Subotica 1-3, Belgrade 11129, Serbia.
   [Toljic, Bosko; Milasin, Jelena] Univ Belgrade, Sch Dent Med, Dept Human Genet, Belgrade, Serbia.
   [Jevtovic, Djordje] Univ Belgrade, Sch Med, Infect & Trop Dis Hosp, Belgrade, Serbia.
   [Lukic, Relja] Univ Belgrade, Sch Med, Obstet Gynaecol Clin Narodni front, Belgrade, Serbia.
   [de Luka, Silvio; Trbovich, Alexander] Univ Belgrade, Inst Pathol Physiol, Sch Med, Belgrade, Serbia.
C3 University of Belgrade; University of Belgrade; University of Belgrade;
   University of Belgrade; University of Belgrade
RP Dragovic, G (corresponding author), Univ Belgrade, Sch Med, Dept Pharmacol Clin Pharmacol & Toxicol, Dr Subotica 1-3, Belgrade 11129, Serbia.
EM gordana.dragovic@med.bg.ac.rs
RI Dragović, Gordana/AAQ-1944-2020; Milasin, Jelena/J-1247-2019; Toljic,
   Bosko/JVO-2021-2024; Lukic, Relja/AAL-9944-2021; De Luka,
   Silvio/E-4079-2019
OI Dragovic, Gordana/0000-0002-0438-0309; Milasin,
   Jelena/0000-0002-6225-7210; De Luka, Silvio/0000-0002-0859-9252; Andic,
   Mladen/0000-0002-6312-5404; Toljic, Bosko/0000-0002-6664-2829
FU Ministry of Science and Technological Development of Serbia [175024]
FX The work was part of the project (Grant No 175024) supported by Ministry
   of Science and Technological Development of Serbia.
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NR 41
TC 7
Z9 7
U1 0
U2 7
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0531-5565
EI 1873-6815
J9 EXP GERONTOL
JI Exp. Gerontol.
PD MAY
PY 2021
VL 147
AR 111269
DI 10.1016/j.exger.2021.111269
EA FEB 2021
PG 5
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA RD3EZ
UT WOS:000633367100007
PM 33529748
DA 2025-06-11
ER

PT J
AU Brumby, S
   Kennedy, A
   Chandrasekara, A
AF Brumby, Susan
   Kennedy, Alison
   Chandrasekara, Ananda
TI Alcohol Consumption, Obesity, and Psychological Distress in Farming
   Communities-An Australian Study
SO JOURNAL OF RURAL HEALTH
LA English
DT Article
DE alcohol abuse; health disparities; health promotion; mental health;
   psychology
ID METABOLIC SYNDROME; MENTAL-HEALTH; URBAN; RISK; DRINKING; DISEASE;
   TRENDS
AB Purpose Alcohol consumption patterns nationally and internationally have been identified as elevated in rural and remote populations. In the general Australian population, 20.5% of adult males and 16.9% of adult females drink at short-term, high-risk levels. Farmers are more likely to drink excessively than those living in major cities. This study seeks to explore the relationships between farmers' physical and mental health and their alcohol consumption patterns. Our hypothesis is that farmers consume alcohol at high-risk levels more often than the Australian average and that this consumption is associated with obesity and psychological distress. Methods Cross-sectional descriptive data were collected within Australian farming communities from 1,792 consenting adults in 97 locations across Australia. Data on anthropometric measurements, general physical attributes and biochemical assessments were used to explore the interrelationships of self-reported alcohol consumption patterns with obesity, psychological distress, and other physical health parameters. Findings There was a higher prevalence of short-term, high-risk alcohol consumption (56.9% in men and 27.5% in women) reported in the study compared with national data. There was also a significant positive association between the prevalence of high-risk alcohol consumption and the prevalence of obesity and abdominal adiposity in psychologically distressed participants. Conclusions The prevalence of short-term, high-risk alcohol consumption practices in this cohort of farming men and women is significantly higher than the Australian average. These consumption practices are coupled with a range of other measurable health issues within the farming population, such as obesity, hypertension, psychological distress, and age.
C1 [Brumby, Susan; Kennedy, Alison; Chandrasekara, Ananda] Natl Ctr Farmer Hlth, Western Dist Hlth Serv, Hamilton, Vic 3300, Australia.
   [Brumby, Susan; Chandrasekara, Ananda] Deakin Univ, Sch Med, Geelong, Vic 3217, Australia.
   [Kennedy, Alison] Deakin Univ, Sch Psychol, Geelong, Vic 3217, Australia.
C3 Deakin University; Deakin University
RP Brumby, S (corresponding author), Natl Ctr Farmer Hlth, POB 283, Hamilton, Vic 3300, Australia.
EM susan.brumby@deakin.edu.au
RI Chandrasekara, Ananda/AAV-4623-2021
OI Brumby, Susan/0000-0001-6332-3374; Chandrasekara, Prof.
   Ananda/0000-0003-0947-6083
FU Joint Research Venture for Farm Health and Safety [WDH-1A]; Gardiner
   Foundation; WestVic Dairy, Victoria, Australia [CDMP1/002]; Joint
   Research Venture for Farm Health and Safety, Cotton Research &
   Development Corporation and Sugar Research & Development Corporation
   (WDH-2J), Australia; Victorian Department of Primary Industries,
   Australia; Victorian Department of Human Services, Australia; Department
   of Health and Ageing, Australia
FX This research was supported by The Joint Research Venture for Farm
   Health and Safety (WDH-1A), managed by the Rural Industries Research
   Development Corporation, Australia; Gardiner Foundation and WestVic
   Dairy (CDMP1/002), Victoria, Australia; The Joint Research Venture for
   Farm Health and Safety, Cotton Research & Development Corporation and
   Sugar Research & Development Corporation (WDH-2J), Australia; Victorian
   Department of Primary Industries, Australia; Victorian Department of
   Human Services, Australia; and the Department of Health and Ageing,
   Australia.
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NR 46
TC 48
Z9 51
U1 0
U2 26
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0890-765X
EI 1748-0361
J9 J RURAL HEALTH
JI J. Rural Health
PD SUM
PY 2013
VL 29
IS 3
BP 311
EP 319
DI 10.1111/jrh.12001
PG 9
WC Health Care Sciences & Services; Health Policy & Services; Public,
   Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services; Public, Environmental & Occupational
   Health
GA 171NQ
UT WOS:000320936500009
PM 23802933
DA 2025-06-11
ER

PT J
AU Melo, DS
   Costa-Pereira, LV
   Santos, CS
   Mendes, BF
   Costa, KB
   Santos, CFF
   Rocha-Vieira, E
   Magalhaes, FC
   Esteves, EA
   Ferreira, AJ
   Guatimosim, S
   Dias-Peixoto, MF
AF Melo, Dirceu S.
   Costa-Pereira, Liliane V.
   Santos, Carina S.
   Mendes, Bruno F.
   Costa, Karine B.
   Santos, Cynthia Fernandes F.
   Rocha-Vieira, Etel
   Magalhaes, Flavio C.
   Esteves, Elizabethe A.
   Ferreira, Anderson J.
   Guatimosim, Silvia
   Dias-Peixoto, Marco F.
TI Severe Calorie Restriction Reduces Cardiometabolic Risk Factors and
   Protects Rat Hearts from Ischemia/Reperfusion Injury
SO FRONTIERS IN PHYSIOLOGY
LA English
DT Article
DE cardiac function; cardiometabolic risk factors; cardioprotection; severe
   calorie restriction; oxidative stress
ID FOOD RESTRICTION; INSULIN-RESISTANCE; OXIDATIVE STRESS; DISEASE; PLASMA;
   IMPACT
AB Background and Aims: Recent studies have proposed that if a severe caloric restriction (SCR) is initiated at the earliest period of postnatal life, it can lead to beneficial cardiac adaptations later on. We investigated the effects of SCR in Wistar rats from birth to adult age on risk factors for cardiac diseases (CD), as well as cardiac function, redox status, and HSP72 content in response to ischemia/reperfusion (I/R) injury.
   Methods and Results: From birth to the age of 3 months, CR50 rats were fed 50% of the food that the ad libitum group (AL) was fed. Food intake was assessed daily and body weight were assessed weekly. In the last week of the SCR protocol, systolic blood pressure and heart rate were measured and the double product index was calculated. Also, oral glucose and intraperitoneal insulin tolerance tests were performed. Thereafter, rats were decapitated, visceral fat was weighed, and blood and hearts were harvested for biochemical, functional, tissue redox status, and western blot analyzes. Compared to AL, CR50 rats had reduced the main risk factors for CD. Moreover, the FR50 rats showed increased cardiac function both at baseline conditions (45% > AL rats) and during the post-ischemic period (60% > AL rats) which may be explained by a decreased cardiac oxidative stress and increased HSP72 content.
   Conclusion: SCR from birth to adult age reduced risk factors for CD, increased basal cardiac function and protected hearts from the I/R, possibly by a mechanism involving ROS.
C1 [Melo, Dirceu S.; Costa-Pereira, Liliane V.; Santos, Carina S.; Mendes, Bruno F.; Costa, Karine B.; Rocha-Vieira, Etel; Magalhaes, Flavio C.; Esteves, Elizabethe A.; Guatimosim, Silvia; Dias-Peixoto, Marco F.] Soc Brasileira Fisiol, Programa Multictr Pos Grad Ciencias Fisiol, Sao Paulo, Brazil.
   [Melo, Dirceu S.; Santos, Cynthia Fernandes F.; Rocha-Vieira, Etel] Univ Fed Vales Jequitinhonha & Mucuri, Fac Med, Campus JK, Diamantina, Brazil.
   [Magalhaes, Flavio C.; Esteves, Elizabethe A.; Dias-Peixoto, Marco F.] Univ Fed Vales Jequitinhonha & Mucuri, Fac Ciencias Biol & Saude, Diamantina, Brazil.
   [Ferreira, Anderson J.] Univ Fed Minas Gerais, Dept Morfol, Belo Horizonte, MG, Brazil.
   [Guatimosim, Silvia] Univ Fed Minas Gerais, Dept Fisiol & Biofis, Belo Horizonte, MG, Brazil.
C3 Sociedade Brasileira de Fisiologia; Universidade Federal dos Vales do
   Jequitinhonha e Mucuri (UFVJM); Universidade Federal dos Vales do
   Jequitinhonha e Mucuri (UFVJM); Universidade Federal de Minas Gerais;
   Universidade Federal de Minas Gerais
RP Dias-Peixoto, MF (corresponding author), Soc Brasileira Fisiol, Programa Multictr Pos Grad Ciencias Fisiol, Sao Paulo, Brazil.
EM marcofabriufvjm@gmail.com
RI DIAS PEIXOTO, MARCO FABRICIO/AAC-7943-2022; Esteves,
   Elizabethe/AAX-2455-2021; Costa, Karine/HMO-7486-2023; Guatimosim,
   Silvia/AAN-7441-2021; Rocha-Vieira, Etel/A-2524-2017; de Castro
   Magalhaes, Flavio/AAB-5540-2022
OI Rocha-Vieira, Etel/0000-0001-6908-7237; Costa, Karine
   Beatriz/0000-0002-3383-3995; Guatimosim, Silvia/0000-0001-8386-3722;
   Melo, Dirceu/0000-0002-7593-7514; Esteves, Elizabethe
   Adriana/0000-0003-1435-8364; DIAS PEIXOTO, MARCO
   FABRICIO/0000-0003-3324-3634; de Castro Magalhaes,
   Flavio/0000-0002-1963-982X
FU Brazilian agency FAPEMIG (Fundacao de Amparo a Pesquisa do Estado de
   Minas Gerais) [APQ-00075-15]; Brazilian agency CAPES (Coordenacao de
   Aperfeicoamento de Pessoal de Nivel Superior); Brazilian agency CNPq
   (Conselho Nacional de Desenvolvimento Cientifico e Tecnologico)
   [479807/2013-2]
FX This study was partially supported by the Brazilian agencies FAPEMIG
   (Fundacao de Amparo a Pesquisa do Estado de Minas Gerais, APQ-00075-15),
   CAPES (Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior) and
   CNPq (Conselho Nacional de Desenvolvimento Cientifico e Tecnologico,
   479807/2013-2).
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NR 41
TC 29
Z9 31
U1 0
U2 12
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-042X
J9 FRONT PHYSIOL
JI Front. Physiol.
PD APR 8
PY 2016
VL 7
AR 106
DI 10.3389/fphys.2016.00106
PG 8
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA DI7KO
UT WOS:000373678600001
PM 27092082
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Kahleova, H
   Pelikanova, T
AF Kahleova, Hana
   Pelikanova, Terezie
TI Vegetarian Diets in the Prevention and Treatment of Type 2 Diabetes
SO JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION
LA English
DT Review
DE diet; prevention; treatment; type 2 diabetes; vegetarian
ID POLYUNSATURATED FATTY-ACIDS; CARDIOVASCULAR-DISEASE RISK; CORONARY
   HEART-DISEASE; RED MEAT CONSUMPTION; LIFE-STYLE CHANGES;
   QUALITY-OF-LIFE; INSULIN SENSITIVITY; BLOOD-PRESSURE; PROTEIN-INTAKE;
   METABOLIC SYNDROME
AB Observational studies show that prevalence of type 2 diabetes is 1.6 to 2times lower in vegetarians than in the general population, even after adjustment for differences in body mass index (BMI). Clinical interventional trials demonstrated that vegetarian diets lead to a greater weight loss and greater reduction in fasting plasma glucose, HbA1c, blood lipids, and hypoglycemic medication than a conventional hypocaloric diet in subjects with type 2 diabetes. We found a greater reduction in visceral fat and greater improvements in insulin resistance and oxidative stress markers with a vegetarian compared to a conventional hypocaloric diabetic diet. Vegetarian diets are sustainable in the long term and may elicit desirable improvements not only in physical health but also in mental health.The American Dietetic Association states that well-planned vegetarian diets are healthy and nutritionally adequate and they may be beneficial in prevention and treatment of some illnesses. Larger clinical trials are needed to confirm the effectiveness and promote the inclusion of vegetarian diets in dietary guidelines for prevention and treatment of type 2 diabetes.
C1 [Kahleova, Hana; Pelikanova, Terezie] Inst Clin & Expt Med, Prague 14021, Czech Republic.
C3 Institute for Clinical & Experimental Medicine (IKEM)
RP Kahleova, H (corresponding author), Inst Clin & Expt Med, Ctr Diabet, Videnska 1958-9, Prague 14021, Czech Republic.
EM hana.kahleova@gmail.com
RI Kahleova, Hana/V-9080-2019
OI Kahleova, Hana/0000-0003-0491-3993
FU Ministry of Health, Prague, Czech Republic [IGA MZCR NT/14250-3]; IKEM,
   Prague, Czech Republic [MZCR 00023001]
FX This work was supported by the project grant IGA MZCR NT/14250-3 from
   the Ministry of Health, Prague, Czech Republic, and Institutional
   Support MZCR 00023001 (IKEM, Prague, Czech Republic).
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NR 150
TC 47
Z9 52
U1 3
U2 144
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 0731-5724
EI 1541-1087
J9 J AM COLL NUTR
JI J. Am. Coll. Nutr.
PD SEP 3
PY 2015
VL 34
IS 5
BP 448
EP 458
DI 10.1080/07315724.2014.976890
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA CR6QN
UT WOS:000361472500011
PM 25915002
DA 2025-06-11
ER

PT J
AU Lu, D
   Dopart, R
   Kendall, DA
AF Lu, Dai
   Dopart, Rachel
   Kendall, Debra A.
TI Controlled downregulation of the cannabinoid CB1 receptor provides a
   promising approach for the treatment of obesity and obesity-derived type
   2 diabetes
SO CELL STRESS & CHAPERONES
LA English
DT Article
DE CB1; Obesity; Type two diabetes mellitus; Inverse agonist;
   Endocannabinoid
ID ENDOPLASMIC-RETICULUM STRESS; CARDIOMETABOLIC RISK-FACTORS;
   NECROSIS-FACTOR-ALPHA; ENDOCANNABINOID SYSTEM; INSULIN-RESISTANCE;
   ADIPOSE-TISSUE; ANTAGONIST RIMONABANT; FOOD-INTAKE; MITOCHONDRIAL
   BIOGENESIS; MACROPHAGE INFILTRATION
AB Increased activity of the endocannabinoid system has emerged as a pathogenic factor in visceral obesity, which is a risk factor for type 2 diabetes mellitus (T2DM). The endocannabinoid system is composed of at least two G-protein-coupled receptors (GPCRs), the cannabinoid receptor type 1 (CB1), and the cannabinoid receptor type 2 (CB2). Downregulation of CB1 activity in rodents and humans has proven efficacious to reduce food intake, abdominal adiposity, fasting glucose levels, and cardiometabolic risk factors. Unfortunately, downregulation of CB1 activity by universally active CB1 inverse agonists has been found to elicit psychiatric side effects, which led to the termination of using globally active CB1 inverse agonists to treat diet-induced obesity. Interestingly, preclinical studies have shown that downregulation of CB1 activity by CB1 neutral antagonists or peripherally restricted CB1 inverse agonists provided similar anorectic effects and metabolic benefits without psychiatric side effects seen in globally active CB1 inverse agonists. Furthermore, downregulation of CB1 activity may ease endoplasmic reticulum and mitochondrial stress which are contributors to obesity-induced insulin resistance and type 2 diabetes. This suggests new approaches for cannabinoid-based therapy in the management of obesity and obesity-related metabolic disorders including type 2 diabetes.
C1 [Lu, Dai] Texas A&M Univ, Rangel Coll Pharm, Hlth Sci Ctr, Kingsville, TX 78363 USA.
   [Dopart, Rachel; Kendall, Debra A.] Univ Connecticut, Dept Pharmaceut Sci, Storrs, CT 06269 USA.
C3 Texas A&M University System; Texas A&M University Kingsville; Texas A&M
   University College Station; Texas A&M Health Science Center; University
   of Connecticut
RP Kendall, DA (corresponding author), Univ Connecticut, Dept Pharmaceut Sci, 69 N Eagleville Rd, Storrs, CT 06269 USA.
EM debra.kendall@uconn.edu
FU National Institutes of Health [DA020763]; Faculty Development Fund from
   Texas A&M Health Sciences Center
FX The authors thank Kwang Hyun Ahn for his assistance with the manuscript.
   This work was supported in part by a National Institutes of Health Grant
   DA020763 (to D.A.K.) and a Faculty Development Fund from Texas A&M
   Health Sciences Center (to D.L.).
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PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1355-8145
EI 1466-1268
J9 CELL STRESS CHAPERON
JI Cell Stress Chaperones
PD JAN
PY 2016
VL 21
IS 1
BP 1
EP 7
DI 10.1007/s12192-015-0653-5
PG 7
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA CY8BZ
UT WOS:000366634800001
PM 26498013
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Conti, E
   Andreotti, F
   Sestito, A
   Riccardi, P
   Menini, E
   Crea, F
   Maseri, A
   Lanza, GA
AF Conti, E
   Andreotti, F
   Sestito, A
   Riccardi, P
   Menini, E
   Crea, F
   Maseri, A
   Lanza, GA
TI Reduced levels of insulin-like growth factor-1 in patients with angina
   pectoris, positive exercise stress test, and angiographically normal
   epicardial coronary arteries
SO AMERICAN JOURNAL OF CARDIOLOGY
LA English
DT Article
ID FACTOR-I; MICROVASCULAR ANGINA; NITRIC-OXIDE; SYNDROME-X; IGF-I; GLUCOSE
   CLAMP; RESISTANCE; HYPERINSULINEMIA; VOLUNTEERS; RECEPTOR
AB Serum insulin-like growth factor-1 (IGF-1) concentrations were found to be lower (p = 0.002) and insulin levels higher (p = 0.004) in patients with syndrome X than in healthy controls. There was an inverse correlation between insulin and IGF-1 blood levels (r = -0.54, p = 0.005), suggesting that the reduced IGF-1 levels may be involved in the impaired insulin sensitivity of patients with syndrome X.
C1 Catholic Univ, Inst Cardiol, Rome, Italy.
   Catholic Univ, Inst Obstet & Gynaecol, Rome, Italy.
   Catholic Univ, Hormones Lab, Rome, Italy.
C3 Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli;
   Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli;
   Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli
RP Conti, E (corresponding author), Univ Cattolica Sacro Cuore, Ist Cardiol, Largo A Gemelli 8, I-00168 Rome, Italy.
RI Andreotti, Felicita/A-9962-2019; riccardi, pierfrancesco/ILM-2543-2023;
   Crea, Filippo/AAC-9754-2022; Lanza, Gaetano/AAC-2660-2019
OI Andreotti, Felicita/0000-0002-1456-6430; Conti,
   Elena/0000-0001-8565-9645
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NR 20
TC 36
Z9 39
U1 0
U2 2
PU EXCERPTA MEDICA INC
PI NEW YORK
PA 650 AVENUE OF THE AMERICAS, NEW YORK, NY 10011 USA
SN 0002-9149
J9 AM J CARDIOL
JI Am. J. Cardiol.
PD APR 15
PY 2002
VL 89
IS 8
BP 973
EP +
AR PII S0002-9149(02)02250-6
DI 10.1016/S0002-9149(02)02250-6
PG 5
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 543FX
UT WOS:000175091700015
PM 11950439
DA 2025-06-11
ER

PT J
AU Gyawali, P
   Richards, RS
   Bwititi, PT
   Nwose, EU
AF Gyawali, Prajwal
   Richards, Ross S.
   Bwititi, Phillip T.
   Nwose, Ezekiel Uba
TI Association of abnormal erythrocyte morphology with oxidative stress and
   inflammation in metabolic syndrome
SO BLOOD CELLS MOLECULES AND DISEASES
LA English
DT Article
DE Erythrocyte morphology; Oxidative stress; Inflammation; Metabolic
   syndrome; Hemorheology
ID HEMORHEOLOGY; MEMBRANE; INDEX; SHAPE
AB In carrying out their role of free radical scavenging, erythrocytes become damaged due to oxidation of membrane lipids and proteins. Such damage may change the morphology of the erythrocytes. The present study aims to demonstrate change in erythrocyte morphology in MetS and associate the changes with increased oxidative stress and inflammation that were shown in our recent study. One hundred participants were recruited from a rural town of Australia. Whole blood viscosity, erythrocyte aggregation, erythrocyte deformability, lipid profile and blood sugar level, oxidative stress markers (erythrocyte reduced glutathione, superoxide dismutase, urinary isoprostanes) and inflammatory markers (high sensitivity C-reactive protein) were measured. Erythrocyte morphological study was performed by scanning electron microscopy. Recruited participants were classified into MetS and non-MetS following the National Cholesterol Education Program Adult Treatment Panel III definition. Data were analyzed by IBM SPSS 20 software. The mean percentages of biconcave cells were decreased whereas acanthocytes, stomatocytes and echinocytes were increased in MetS group compared to healthy controls. Morphologically abnormal erythrocytes were significantly correlated with oxidative stress and chronic inflammation markers. Free radicals generated in increased concentration in MetS seem to damage erythrocyte changing its morphology which possibly could affect other hemorheological parameters. (C) 2015 Elsevier Inc. All rights reserved.
C1 [Gyawali, Prajwal; Richards, Ross S.] Charles Sturt Univ, Sch Community Hlth, Biomed Sci, Albury, NSW 2640, Australia.
   [Bwititi, Phillip T.] Charles Sturt Univ, Sch Biomed Sci, Albury, NSW 2640, Australia.
   [Nwose, Ezekiel Uba] Charles Sturt Univ, Sch Community Hlth, Albury, NSW 2640, Australia.
C3 Charles Sturt University; Charles Sturt University; Charles Sturt
   University
RP Gyawali, P (corresponding author), Charles Sturt Univ, Sch Community Hlth, Biomed Sci, Albury, NSW 2640, Australia.
EM clbioprajwal@gmail.com; rorichards@csu.edu.au; pbwititi@csu.edu.au;
   enwose@csu.edu.au
RI Bwititi, Phillip/HTP-8025-2023; Nwose, Ezekiel 'Uba'/I-1333-2018
OI Gyawali, Prajwal/0000-0003-0975-5576; Bwititi,
   Phillip/0000-0002-6265-5913; Nwose, Ezekiel 'Uba'/0000-0003-1318-9853
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NR 23
TC 47
Z9 49
U1 0
U2 12
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 1079-9796
EI 1096-0961
J9 BLOOD CELL MOL DIS
JI Blood Cells Mol. Dis.
PD APR
PY 2015
VL 54
IS 4
BP 360
EP 363
DI 10.1016/j.bcmd.2015.01.005
PG 4
WC Hematology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Hematology
GA CG2HB
UT WOS:000353094400010
PM 25616368
DA 2025-06-11
ER

PT J
AU Mesarwi, OA
   Sharma, EV
   Jun, JC
   Polotsky, VY
AF Mesarwi, Omar A.
   Sharma, Ellora V.
   Jun, Jonathan C.
   Polotsky, Vsevolod Y.
TI Metabolic dysfunction in obstructive sleep apnea: A critical examination
   of underlying mechanisms
SO SLEEP AND BIOLOGICAL RHYTHMS
LA English
DT Review
DE hypoxia; oxidative stress; sleep fragmentation; sympathetic nervous
   system
ID CHRONIC INTERMITTENT HYPOXIA; POSITIVE AIRWAY PRESSURE; IMPROVES INSULIN
   SENSITIVITY; INCREASED OXIDATIVE STRESS; FREE FATTY-ACIDS;
   SYMPATHETIC-NERVOUS-SYSTEM; LONG-TERM FACILITATION; BLOOD-PRESSURE;
   ANGIOTENSIN-II; ADIPOSE-TISSUE
AB It has recently become clear that obstructive sleep apnea (OSA) is an independent risk factor for the development of metabolic syndrome, a disorder of defective energy storage and use. Several mechanisms have been proposed to explain this finding, drawing upon the characteristics that define OSA. In particular, intermittent hypoxia, sleep fragmentation, elevated sympathetic tone, and oxidative stress - all consequences of OSA - have been implicated in the progression of poor metabolic outcomes in OSA. In this review we examine the evidence to support each of these disease manifestations of OSA as a unique risk for metabolic dysfunction. Tissue hypoxia and sleep fragmentation are each directly connected to insulin resistance and hypertension, and each of these also may increase sympathetic tone, resulting in defective glucose homeostasis, excessive lipolysis, and elevated blood pressure. Oxidative stress further worsens insulin resistance and in turn, metabolic dysfunction also increases oxidative stress. However, despite many studies linking each of these individual components of OSA to the development of metabolic syndrome, there are very few reports that actually provide a coherent narrative about the mechanism underlying metabolic dysfunction in OSA.
C1 [Mesarwi, Omar A.; Jun, Jonathan C.; Polotsky, Vsevolod Y.] Johns Hopkins Univ, Sch Med, Baltimore, MD USA.
   [Sharma, Ellora V.] Northeast Ohio Med Univ, Rootstown, OH USA.
C3 Johns Hopkins University; University System of Ohio; Northeast Ohio
   Medical University (NEOMED)
RP Mesarwi, OA (corresponding author), Johns Hopkins Asthma & Allergy Ctr, 5501 Hopkins Bayview Circle,Rm 4B74, Baltimore, MD 21224 USA.
EM omesarwi@jhmi.edu
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NR 228
TC 56
Z9 60
U1 0
U2 7
PU SPRINGER JAPAN KK
PI TOKYO
PA SHIROYAMA TRUST TOWER 5F, 4-3-1 TORANOMON, MINATO-KU, TOKYO, 105-6005,
   JAPAN
SN 1446-9235
EI 1479-8425
J9 SLEEP BIOL RHYTHMS
JI Sleep Biol. Rhythms
PD JAN
PY 2015
VL 13
IS 1
BP 2
EP 17
DI 10.1111/sbr.12078
PG 16
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA AY3BT
UT WOS:000347460300002
PM 26412981
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Marín-Echeverri, C
   Piedrahita-Blandón, M
   Galvis-Pérez, Y
   Blesso, CN
   Fernández, ML
   Nuñez-Rangel, V
   Barona-Acevedo, J
AF Marin-Echeverri, Catalina
   Piedrahita-Blandon, Manuela
   Galvis-Perez, Yeisson
   Blesso, Christopher N.
   Fernandez, Maria-Luz
   Nunez-Rangel, Vitelbina
   Barona-Acevedo, Jacqueline
TI Improvements in antioxidant status after agraz consumption was
   associated to reductions in cardiovascular risk factors in women with
   metabolic syndrome
SO CYTA-JOURNAL OF FOOD
LA English
DT Article
DE Andean berry; antioxidant enzymes; oxidative stress; total antioxidant
   capacity; vaccinium meridionale; superoxide dismutase; catalase;
   glutathione peroxidase
ID VACCINIUM-MERIDIONALE SWARTZ; LIPID-PEROXIDATION; OXIDATIVE STRESS;
   ANTHOCYANINS; CAPACITY; PLASMA; SUPEROXIDE; DISMUTASE; JUICE;
   PREADIPOCYTES
AB In this study were evaluated the effects of the chronic consumption of agraz (Vaccinium meridionale) on antioxidant status and oxidative stress markers in 40 women with metabolic syndrome (MetS) (47.2 +/- 9.4 years) through a double-blind, crossover design study, in which participants consumed daily agraz or placebo during 4 weeks, separated by a 4-wk washout period. At the end of each intervention period, endogenous antioxidant enzymes activity, serum total antioxidant capacity (TAC) (ferric reducing ability of plasma [FRAP]; Oxygen Radical Absorbance Capacity [ORAC] and 2,2MODIFIER LETTER PRIME-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) [ABTS]), and oxidative stress markers (Oxo-2MODIFIER LETTER PRIME-deoxyguanosine (8-OHdG) and F2-isoprostane) were determined. Women who increased endogenous antioxidant enzymes activity and serum TAC after agraz consumption, compared to placebo, significantly reduced oxidative stress markers, total cholesterol, LDL-cholesterol (LDL-c) levels, and waist circumference, demonstrating beneficial effects in the group of women in whom antioxidant parameters increased after agraz consumption, evidencing an individual variability in response to the beverage consumed.
C1 [Marin-Echeverri, Catalina; Piedrahita-Blandon, Manuela; Galvis-Perez, Yeisson; Nunez-Rangel, Vitelbina; Barona-Acevedo, Jacqueline] Univ Antioquia UdeA, Sch Microbiol, Toxinol & Food & Therapeut Alternat, Calle 70 52-21, Medellin, Colombia.
   [Blesso, Christopher N.; Fernandez, Maria-Luz] Univ Connecticut, Dept Nutr Sci, Storrs, CT USA.
C3 Universidad de Antioquia; University of Connecticut
RP Barona-Acevedo, J (corresponding author), Univ Antioquia UdeA, Sch Microbiol, Toxinol & Food & Therapeut Alternat, Calle 70 52-21, Medellin, Colombia.
EM maria.barona@udea.edu.co
RI Blesso, Christopher/N-9495-2014
OI Fernandez, Maria-Luz/0000-0002-1835-0792; Marin Echeverri,
   Catalina/0000-0002-4267-5677; Galvis Perez, Yeisson/0000-0002-3600-2580;
   Barona Acevedo, Maria Jacqueline/0000-0002-0592-9324; Blesso,
   Christopher/0000-0002-4434-4839
FU Departamento Administrativo de Ciencia, Tecnologia e Innovacion
   (COLCIENCIAS) [111565740563, 657-2014, FP44842-124-2017]; Universidad de
   Antioquia, Medellin-Colombia
FX This study was supported by Departamento Administrativo de Ciencia,
   Tecnologia e Innovacion (COLCIENCIAS) through two different grants:
   [111565740563, Contract No. 657-2014 and FP44842-124-2017]; and the
   Universidad de Antioquia, Medellin-Colombia.
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NR 52
TC 3
Z9 3
U1 0
U2 5
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1947-6337
EI 1947-6345
J9 CYTA-J FOOD
JI CyTA-J. Food
PD JAN 1
PY 2021
VL 19
IS 1
BP 238
EP 246
DI 10.1080/19476337.2021.1884606
PG 9
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA QR6CU
UT WOS:000625305100001
OA gold
DA 2025-06-11
ER

PT J
AU Mattson, MP
AF Mattson, Mark P.
TI Roles of the lipid peroxidation product 4-hydroxynonenal in obesity, the
   metabolic syndrome, and associated vascular and neurodegenerative
   disorders
SO EXPERIMENTAL GERONTOLOGY
LA English
DT Review
DE Alzheimer's disease; Atherosclerosis; Diabetes; Insulin resistance;
   Lipid peroxidation; Metabolic syndrome
ID AMYLOID BETA-PEPTIDE; LOW-DENSITY-LIPOPROTEIN; TRANSGENIC MOUSE MODEL;
   ALPHA-LIPOIC ACID; OXIDATIVE STRESS; INSULIN-RESISTANCE; CALORIE
   RESTRICTION; ALDEHYDIC PRODUCT; APOLIPOPROTEIN-E; GLUTAMATE TRANSPORT
AB A rising tide of obesity and type 2 diabetes has resulted from the development of technologies that have made inexpensive high calorie foods readily available and exercise unnecessary for many people. Obesity and the metabolic syndrome (insulin resistance, visceral adiposity and dyslipidemia) wreak havoc on cells throughout the body thereby promoting cardiovascular and kidney disease, and degenerative diseases of the brain and body. Obesity and insulin resistance promote disease by increasing oxidative damage to proteins, lipids and DNA as the result of a combination of increased free radical production and an impaired ability of cells to detoxify the radicals and repair damaged molecules. By covalently modifying membrane-associated proteins, the membrane lipid peroxidation product 4-hydroxynonenal (HNE) may play particularly sinister roles in the metabolic syndrome and associated disease processes. HNE can damage pancreatic beta cells and can impair the ability of muscle and liver cells to respond to insulin. HNE may promote atherosclerosis by modifying lipoproteins and can cause cardiac cell damage by impairing metabolic enzymes. An adverse role for HNE in the brain in obesity and the metabolic syndrome is suggested by studies showing that HNE levels are increased in brain cells with aging and Alzheimer's disease. HNE can cause the dysfunction and degeneration of neurons by modifying membrane-associated glucose and glutamate transporters, ion-motive ATPases, enzymes involved in amyloid metabolism, and cytoskeletal proteins. Exercise and dietary energy restriction reduce HNE production and may also increase cellular systems for HNE detoxification including glutathione and oxidoreductases. The recent development of low molecular weight molecules that scavenge HNE suggests that HNE can be targeted in the design of drugs for the treatment of obesity, the metabolic syndrome, and associated disorders. (C) 2009 Published by Elsevier Inc.
C1 NIA, Intramural Res Program, Neurosci Lab, Baltimore, MD 21224 USA.
C3 National Institutes of Health (NIH) - USA; NIH National Institute on
   Aging (NIA)
RP Mattson, MP (corresponding author), NIA, Intramural Res Program, Neurosci Lab, BRC 5C214,251 Bayview Blvd, Baltimore, MD 21224 USA.
EM mattsonm@grc.nia.nih.gov
RI Mattson, Mark/F-6038-2012
FU National Institute on Aging
FX I thank KC Alexander for editorial assistance. This work was supported
   by the Intramural Research Program of the National Institute on Aging.
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NR 134
TC 229
Z9 246
U1 2
U2 39
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0531-5565
EI 1873-6815
J9 EXP GERONTOL
JI Exp. Gerontol.
PD OCT
PY 2009
VL 44
IS 10
BP 625
EP 633
DI 10.1016/j.exger.2009.07.003
PG 9
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA 513ZL
UT WOS:000271362700001
PM 19622391
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Basu, A
   Betts, NM
   Mulugeta, A
   Tong, C
   Newman, E
   Lyons, TJ
AF Basu, Arpita
   Betts, Nancy M.
   Mulugeta, Afework
   Tong, Capella
   Newman, Emily
   Lyons, Timothy J.
TI Green tea supplementation increases glutathione and plasma antioxidant
   capacity in adults with the metabolic syndrome
SO NUTRITION RESEARCH
LA English
DT Article
DE Green tea; Antioxidants; Glutathione; Copper; Iron; Metabolic syndrome
ID OXIDATIVE STRESS; BLACK TEA; LIPID-PEROXIDATION; ALPHA-TOCOPHEROL; IRON;
   POLYPHENOLS; EXTRACT; CONSUMPTION; ENHANCEMENT; CAROTENOIDS
AB Green tea, a popular polyphenol-containing beverage, has been shown to alleviate clinical features of the metabolic syndrome. However, its effects in endogenous antioxidant biomarkers are not clearly understood. Thus, we tested the hypothesis that green tea supplementation will upregulate antioxidant parameters (enzymatic and nonenzymatic) in adults with the metabolic syndrome. Thirty-five obese participants with the metabolic syndrome were randomly assigned to receive one of the following for 8 weeks: green tea (4 cups per day), control (4 cups water per day), or green tea extract (2 capsules and 4 cups water per day). Blood samples and dietary information were collected at baseline (0 week) and 8 weeks of the study. Circulating carotenoids (alpha-carotene, beta-carotene, lycopene) and tocopherols (alpha-tocopherol, gamma-tocopherol) and trace elements were measured using high-performance liquid chromatography and inductively coupled plasma mass spectroscopy, respectively. Serum antioxidant enzymes (glutathione peroxidase, glutathione, catalase) and plasma antioxidant capacity were measured spectrophotometrically. Green tea beverage and green tea extract significantly increased plasma antioxidant capacity (1.5 to 2.3 mu mol/L and 1.2 to 2.5 mu mol/L, respectively; P < .05) and whole blood glutathione (1783 to 2395 mu g/g hemoglobin and 1905 to 2751 mu g/g hemoglobin, respectively; P < .05) vs controls at 8 weeks. No effects were noted in serum levels of carotenoids and tocopherols and glutathione peroxidase and catalase activities. Green tea extract significantly reduced plasma iron vs baseline (128 to 92 mu g/dL, P < .02), whereas copper, zinc, and selenium were not affected. These results support the hypothesis that green tea may provide antioxidant protection in the metabolic syndrome. (C) 2013 Elsevier Inc. All rights reserved.
C1 [Basu, Arpita; Betts, Nancy M.; Mulugeta, Afework; Tong, Capella; Newman, Emily] Oklahoma State Univ, Stillwater, OK 74078 USA.
   [Lyons, Timothy J.] Univ Oklahoma, Hlth Sci Ctr, Harold Hamm Diabet Ctr, Oklahoma City, OK 73104 USA.
   [Lyons, Timothy J.] Univ Oklahoma, Hlth Sci Ctr, Sect Endocrinol & Diabet, Oklahoma City, OK 73104 USA.
C3 Oklahoma State University System; Oklahoma State University -
   Stillwater; University of Oklahoma System; University of Oklahoma Health
   Sciences Center; University of Oklahoma System; University of Oklahoma
   Health Sciences Center
RP Basu, A (corresponding author), Oklahoma State Univ, Stillwater, OK 74078 USA.
EM arpita.basu@okstate.edu
RI Gebremichael, Anwar/D-2388-2016
OI Mulugeta, Afework/0000-0003-0707-4363; Lyons,
   Timothy/0000-0003-2106-1622
FU University of Oklahoma Health Sciences Center General Clinical Research
   Center, National Center for Research Resources, National Institutes of
   Health [M01-RR14467]; Oklahoma State University; National Institutes of
   Health from the COBRE Program of the National Center for Research
   Resources [P20 RR 024215]
FX The authors wish to thank all OUHSC employees for their participation in
   the study and the Bionutrition and Biostatistical Units at GCRC for
   administration of intervention and patient follow-ups and for
   statistical analyses. We also acknowledge the technical assistance of
   Sandra Peterson in the analyses of plasma trace elements. This work was
   supported in part by the University of Oklahoma Health Sciences Center
   General Clinical Research Center grant M01-RR14467, National Center for
   Research Resources, National Institutes of Health. Support was also
   provided by the Dean's Research Incentive Award at the Oklahoma State
   University. This publication was made possible by National Institutes of
   Health grant number P20 RR 024215 from the COBRE Program of the National
   Center for Research Resources.
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NR 44
TC 83
Z9 93
U1 0
U2 61
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0271-5317
J9 NUTR RES
JI Nutr. Res.
PD MAR
PY 2013
VL 33
IS 3
BP 180
EP 187
DI 10.1016/j.nutres.2012.12.010
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 115WP
UT WOS:000316842900002
PM 23507223
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Nallathambi, R
   Poulev, A
   Zuk, JB
   Raskin, I
AF Nallathambi, Rameshprabu
   Poulev, Alexander
   Zuk, Joshua B.
   Raskin, Ilya
TI Proanthocyanidin-Rich Grape Seed Extract Reduces Inflammation and
   Oxidative Stress and Restores Tight Junction Barrier Function in Caco-2
   Colon Cells
SO NUTRIENTS
LA English
DT Article
DE polyphenol; proanthocyanidin; antioxidant; inflammation; tight junction
ID AKKERMANSIA-MUCINIPHILA; METABOLIC ENDOTOXEMIA; MODEL; RESVERATROL;
   ACTIVATION; MICROBIOTA; OBESITY; GROWTH
AB Grape polyphenols have previously been shown to improve gut health and attenuate the symptoms of metabolic syndrome; however, the mechanism of these beneficial effects is still debated. In this study, we investigated the protective effect of proanthocyanidin-rich grape seed extract (GSE) on bacterial lipopolysaccharide (LPS)-induced oxidative stress, inflammation, and barrier integrity of human Caco-2 colon cells. GSE significantly reduced the LPS-induced intracellular reactive oxygen species (ROS) production and mitochondrial superoxide production, and upregulated the expression of antioxidant enzyme genes. GSE also restored the LPS-damaged mitochondrial function by increasing mitochondrial membrane potential. In addition, GSE increased the expression of tight junction proteins in the LPS-treated Caco-2 cells, increased the expression of anti-inflammatory cytokines, and decreased pro-inflammatory cytokine gene expression. Our findings suggest that GSE exerts its beneficial effects on metabolic syndrome by scavenging intestinal ROS, thus reducing oxidative stress, increasing epithelial barrier integrity, and decreasing intestinal inflammation.
C1 [Nallathambi, Rameshprabu; Poulev, Alexander; Zuk, Joshua B.; Raskin, Ilya] Rutgers State Univ, Sch Environm & Biol Sci, Dept Plant Biol, New Brunswick, NJ 08901 USA.
C3 Rutgers University System; Rutgers University New Brunswick
RP Raskin, I (corresponding author), Rutgers State Univ, Sch Environm & Biol Sci, Dept Plant Biol, New Brunswick, NJ 08901 USA.
EM rameshprabun@gmail.com; apoulev@sebs.rutgers.edu;
   jbz27@sebs.rutgers.edu; raskin@rutgers.edu
RI Poulev, Alexander/L-6613-2019
OI Poulev, Alexander/0000-0003-0939-0642; Nallathambi,
   Rameshprabu/0000-0001-5173-4133
FU National Institutes of Health (NIH) National Center for Complementary
   and Integrative Health (NCCIH) [1R01AT008618-05, 5T32AT004094-09,
   P50AT002776-01]; NIH/NCCIH [1R01AT008618-05]
FX This work was funded by the National Institutes of Health (NIH) National
   Center for Complementary and Integrative Health (NCCIH)
   (1R01AT008618-05, 5T32AT004094-09, and P50AT002776-01) and the APC was
   funded by the NIH/NCCIH (1R01AT008618-05).
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NR 44
TC 81
Z9 87
U1 5
U2 61
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JUN
PY 2020
VL 12
IS 6
AR 1623
DI 10.3390/nu12061623
PG 13
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA ML1FH
UT WOS:000549220300001
PM 32492806
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU O'Rourke, RW
AF O'Rourke, Robert W.
TI Adipose tissue and the physiologic underpinnings of metabolic disease
SO SURGERY FOR OBESITY AND RELATED DISEASES
LA English
DT Review
DE Adipose tissue; Body mass index; Obesity; Metabolic disease; Cell stress
   responses
ID BODY-MASS INDEX; ALL-CAUSE MORTALITY; NORMAL-WEIGHT; CARDIOMETABOLIC
   RISK; INSULIN SENSITIVITY; OBESITY; FAT; US; ASSOCIATION; PREVALENCE
AB Adipose tissue dysfunction underlies the pathogenesis of metabolic disease. The metrics used to quantify adiposity and its association with metabolic disease, including body mass index, have limitations with important clinical implications. An understanding of the molecular and cellular mechanisms by which adipose tissue regulates systemic metabolism and contributes to metabolic disease will lead to next-generation adipose tissue based therapy. Published by Elsevier Inc. on behalf of American Society for Bariatric Surgery.
C1 [O'Rourke, Robert W.] Univ Michigan, Dept Surg, Med Sch, Michigan Med, Ann Arbor, MI 48109 USA.
   [O'Rourke, Robert W.] Ann Arbor Vet Adm Hosp, Ann Arbor, MI USA.
C3 University of Michigan System; University of Michigan
RP O'Rourke, RW (corresponding author), Michigan Med, Dept Surg, 2210 Taubman Ctr 5343,1500 E Med Ctr Dr, Ann Arbor, MI 48109 USA.
EM rorourke@med.umich.edu
FU National Institutes of Health [R01 DK097449, R01 DK115190]; Veterans
   Administration Merit Grant [I01 CX001811]; Michigan Diabetes Research
   Center (NIH) [P30-DK020572]; National Institute of Diabetes and
   Digestive and Kidney Diseases [P30DK020572] Funding Source: NIH RePORTER
FX R.W.O. is supported by National Institutes of Health Grants ROI
   DK097449, ROI DK115190, Veterans Administration Merit Grant I01
   CX001811, and a Pilot and Feasibility Grant from the Michigan Diabetes
   Research Center (NIH Grant P30-DK020572)
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NR 67
TC 32
Z9 34
U1 0
U2 7
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1550-7289
EI 1878-7533
J9 SURG OBES RELAT DIS
JI Surg. Obes. Relat. Dis.
PD NOV
PY 2018
VL 14
IS 11
BP 1755
EP 1763
DI 10.1016/j.soard.2018.07.032
PG 9
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA HF9OD
UT WOS:000454570400018
PM 30193906
OA Bronze, Green Accepted
DA 2025-06-11
ER

PT J
AU de Groot, M
   Doyle, T
   Kushnick, M
   Shubrook, J
   Merrill, J
   Rabideau, E
   Schwartz, F
AF de Groot, Mary
   Doyle, Todd
   Kushnick, Michael
   Shubrook, Jay
   Merrill, Jennifer
   Rabideau, Erin
   Schwartz, Frank
TI Can Lifestyle Interventions Do More Than Reduce Diabetes Risk? Treating
   Depression in Adults With Type 2 Diabetes With Exercise and Cognitive
   Behavioral Therapy
SO CURRENT DIABETES REPORTS
LA English
DT Article
DE Depression; Type 2 diabetes; Exercise; Cognitive behavioral therapy;
   Lifestyle interventions
ID QUALITY-OF-LIFE; COMORBID DEPRESSION; SOCIOECONOMIC-STATUS; MAJOR
   DEPRESSION; BECK DEPRESSION; MORTALITY; SYMPTOMS; ASSOCIATION; HEALTH;
   INDIVIDUALS
AB The epidemic of metabolic syndrome, prediabetes, and type 2 diabetes is global in scope and comprehensive in its impact on individuals, health care systems, and societies. One in four patients with diabetes will experience depression in their lifetime. Comorbid depression is associated with poorer outcomes, greater functional disability, and early mortality. Prior studies have demonstrated beneficial effects of exercise as an efficacious form of treatment for depression in the general population. Few studies have evaluated this strategy in patients with prediabetes or type 2 diabetes. Program ACTIVE (Appalachians Coming Together to Increase Vital Exercise) was designed to treat depression among adults with type 2 diabetes by pairing aerobic activity with individual cognitive behavioral therapy. This combination treatment approach has been shown to be feasible to implement in a rural environment and promising in terms of depression, diabetes, and cardiovascular outcomes. Data from this study suggest that exercise can be used to achieve multiple benefits for adults with type 2 diabetes. Future work to compare this approach to singular treatment strategies for adults at risk for type 2 diabetes is needed.
C1 [de Groot, Mary] Indiana Univ, Dept Med, Div Endocrinol & Metab, Diabet Translat Res Ctr, Indianapolis, IN 46202 USA.
   [de Groot, Mary] Indiana Univ Sch Med, Dept Med, Indianapolis, IN USA.
   [Doyle, Todd; Merrill, Jennifer; Rabideau, Erin] Ohio Univ, Dept Psychol, Athens, OH 45701 USA.
   [Kushnick, Michael] Ohio Univ, Coll Hlth Sci & Profess, Sch Hlth Sci & Wellness, Athens, OH 45701 USA.
   [Shubrook, Jay] Ohio Univ, Coll Osteopath Med, Dept Family Med, Athens, OH 45701 USA.
   [Schwartz, Frank] Ohio Univ, Coll Osteopath Med, Dept Specialty Med, Athens, OH 45701 USA.
C3 Indiana University System; Indiana University Indianapolis; Indiana
   University System; Indiana University Bloomington; University System of
   Ohio; Ohio University; University System of Ohio; Ohio University;
   University System of Ohio; Ohio University; University System of Ohio;
   Ohio University
RP de Groot, M (corresponding author), Indiana Univ, Dept Med, Div Endocrinol & Metab, Diabet Translat Res Ctr, 410 W 10th St, Indianapolis, IN 46202 USA.
EM mdegroot@iupui.edu
RI Kushnick, Michael/ABB-1501-2020
OI de Groot, Mary/0000-0003-4021-8824; Kushnick,
   Michael/0000-0001-5550-7675
FU National Institutes of Health [R34DK71545]; Ohio Department of Health,
   Office of Healthy Ohio, Bureau of Health Promotion; Risk Reduction,
   Diabetes Prevention and Control Program; Ohio University Diabetes
   Research Initiative; NIDDK; Ohio Department of Health; Diabetes Research
   Initiative (DRI) at Ohio University
FX Funding for this study was provided by the National Institutes of Health
   R34DK71545, Ohio Department of Health, Office of Healthy Ohio, Bureau of
   Health Promotion and Risk Reduction, Diabetes Prevention and Control
   Program, and the Ohio University Diabetes Research Initiative. Conflicts
   of interest: M. de Groot: has received grant support from the NIDDK; has
   been a consultant for Johnson & Johnson Diabetes Institute; and has
   received payment for lectures including service on speakers bureaus from
   Lilly Foundation; T. Doyle: none; M. Kushnick: has received grant
   support from NIH (R34DK71545) and the Ohio Department of Health; J.
   Shubrook: none; J. Merrill: none; E. Rabideau: received grant support
   from the Diabetes Research Initiative (DRI) at Ohio University; F.
   Schwartz: has received grant support from the NIDDK and NIH.
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NR 41
TC 44
Z9 50
U1 1
U2 45
PU CURRENT MEDICINE GROUP
PI PHILADELPHIA
PA 400 MARKET STREET, STE 700, PHILADELPHIA, PA 19106 USA
SN 1534-4827
EI 1539-0829
J9 CURR DIABETES REP
JI Curr. Diabetes Rep.
PD APR
PY 2012
VL 12
IS 2
BP 157
EP 166
DI 10.1007/s11892-012-0261-z
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism
GA 909XI
UT WOS:000301600000004
PM 22350739
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Chen, R
   Luo, X
   Jiang, XL
   Deng, S
AF Chen, Ru
   Luo, Xi
   Jiang, Xiaoli
   Deng, Shan
TI Vinexin β eficiency exacerbates diet-induced obesity, hepatosteatosis,
   insulin resistance and endoplasmic reticulum stress in mice
SO BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
LA English
DT Article
DE Vinexin 13; Obese; Metabolic syndrome; Hepatosteatosis; Insulin
   resistance; Endoplasmic reticulum stress
ID METABOLIC SYNDROME; PROTEIN; MODEL
AB Vinexin 13 is a member of an adaptor protein family. Previous research has elucidated its role in cell adhesion and growth factor signaling. Recently, several studies demonstrated its role in metabolic ab-normality, such as obesity and atherosclerosis. In this study, we found that vinexin 13-knockout (KO) mice were more obese and gained more obvious visceral fat accumulation than their wildtype (WT) litter-mates fed with high fat diet (HFD). KO mice also showed more severe hepatosteatosis when compared with the WT control, which was in line with the significant increase of key serum lipids in KO mice. Furthermore, we confirmed the inhibited Akt signaling and exacerbated insulin resistance which resulted in high fasting blood glucose in KO mice. The endoplasmic reticulum stress response was found obviously activated which may mediate the metabolic changes in KO mice. Our studies indicated that vinexin 13 deficiency promotes the diet-induced metabolic disorders. (C) 2022 Elsevier Inc. All rights reserved.
C1 [Chen, Ru; Luo, Xi; Deng, Shan] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Cardiol, Wuhan, Peoples R China.
   [Chen, Ru; Luo, Xi; Deng, Shan] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Clin Ctr Human Gene Res, Wuhan, Peoples R China.
   [Jiang, Xiaoli] Huazhong Univ Sci & Technol, Cent Hosp Wuhan, Tongji Med Coll, Dept Cardiol, Wuhan, Peoples R China.
C3 Huazhong University of Science & Technology; Huazhong University of
   Science & Technology; Huazhong University of Science & Technology
RP Deng, S (corresponding author), Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Cardiol, Wuhan, Peoples R China.
EM dengshan1020@hust.edu.cn
FU National Natural Science Foundation of China [81600616]
FX This work was supported by the National Natural Science Foundation of
   China (Youth Programs, No. 81600616).
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NR 24
TC 2
Z9 2
U1 0
U2 5
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0006-291X
EI 1090-2104
J9 BIOCHEM BIOPH RES CO
JI Biochem. Biophys. Res. Commun.
PD MAR 12
PY 2022
VL 596
BP 14
EP 21
DI 10.1016/j.bbrc.2022.01.062
EA FEB 2022
PG 8
WC Biochemistry & Molecular Biology; Biophysics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics
GA YV0IB
UT WOS:000752415700001
PM 35104662
DA 2025-06-11
ER

PT J
AU Celec, P
   Janovicová, L
   Gurecká, R
   Koborová, I
   Gardlík, R
   Sebeková, K
AF Celec, Peter
   Janovicova, Lubica
   Gurecka, Radana
   Koborova, Ivana
   Gardlik, Roman
   Sebekova, Katarina
TI Circulating extracellular DNA is in association with continuous
   metabolic syndrome score in healthy adolescents
SO PHYSIOLOGICAL GENOMICS
LA English
DT Article
DE cell-free DNA; metabolic syndrome; microinflammation; obesity;
   observational study
ID CELL-FREE DNA; OXIDATION PROTEIN PRODUCTS; INFLAMMATORY RESPONSES;
   DIABETES-MELLITUS; MITOCHONDRIAL-DNA; RISK SCORE; PLASMA DNA;
   COMPLICATIONS; OBESITY; ORIGIN
AB Obesity is associated with chronic low-grade inflammation that eventually leads to metabolic complications. Extracellular DNA (ecDNA) is a damage-associated molecular pattern. Extracellular mitochondrial DNA can activate innate immunity. We hypothesized that ecDNA, especially of mitochondrial origin, could be associated with components of the metabolic syndrome in young healthy probands. In a cross-sectional study, healthy adolescents (n = 1,249) provided blood samples. Anthropometric data, blood pressure, and blood counts were assessed. In addition, biochemical analysis of sera or plasma was conducted, including the quantification of advanced oxidation protein products (AOPPs) as a marker of oxidative stress induced by neutrophil or monocyte activation. Plasma ecDNA was isolated and measured by fluorometry. Nuclear and mitochondrial DNA were quantified by realtime PCR. Males had higher total plasma ecDNA [15 (11-21) vs. 11 (8-17) ng/mL; median (interquartile range)), nuclear [1,760 (956-3,273) vs. 1,153 (600-2,292) genome equivalents (GE)/mL], and mitochondria! [37,181 (14,836-90,896) vs. 30,089 (12,587-72,286) GE/mL] DNA. ecDNA correlated positively with the continuous metabolic syndrome score (r = 0.158 for males and r = 0.134 for females). Stronger correlations were found between ecDNA of mitochondria! origin and AOPP (r = 0.202 and 0.186 for males and females, respectively). Multivariate regression analysis revealed associations of nuclear DNA with leukocyte and erythrocyte counts. The results of this study of healthy adolescents show that circulating ecDNA is associated with the risk of metabolic syndrome, not with obesity per se. The association between mitochondrial ecDNA and AOPP requires further attention as it supports a potential role of mitochondria-induced sterile inflammation in the pathogenesis of the metabolic syndrome.
C1 [Celec, Peter; Janovicova, Lubica; Gurecka, Radana; Koborova, Ivana; Gardlik, Roman; Sebekova, Katarina] Comenius Univ, Fac Med, Inst Mol Biomed, Bratislava, Slovakia.
   [Celec, Peter; Gardlik, Roman] Comenius Univ, Fac Med, Inst Pathophysiol, Bratislava, Slovakia.
   [Celec, Peter] Comenius Univ, Fac Nat Sci, Dept Mol Biol, Bratislava, Slovakia.
   [Gurecka, Radana] Comenius Univ, Fac Med, Inst Med Phys Biophys Informat & Telemed, Bratislava, Slovakia.
C3 Comenius University Bratislava; Comenius University Bratislava; Comenius
   University Bratislava; Comenius University Bratislava
RP Celec, P (corresponding author), Comenius Univ, Fac Med, Inst Mol Biomed, Bratislava, Slovakia.; Celec, P (corresponding author), Comenius Univ, Fac Med, Inst Pathophysiol, Bratislava, Slovakia.; Celec, P (corresponding author), Comenius Univ, Fac Nat Sci, Dept Mol Biol, Bratislava, Slovakia.
EM petercelec@gmail.com
RI Sebekova, Katarina/GSD-7056-2022; Gurecka, Radana/AAX-6744-2021;
   Janovicova, Lubica/ABC-5277-2021; Gardlik, Roman/I-3510-2014; Celec,
   Peter/I-7103-2012; Sebekova, Katarina/H-4906-2016
OI Gardlik, Roman/0000-0001-8211-907X; Janovicova,
   Lubica/0009-0002-9176-4593; Celec, Peter/0000-0001-5883-3580; Sebekova,
   Katarina/0000-0002-9641-9265
FU Ministry of Education [VEGA 1/0307/19]; Ministry of Health of the Slovak
   Republic [2018/33LFUK-7]; Slovak Research and Development Agency
   [APVV-0447-12, APVV-16-0273]
FX The study was supported by grants from the Ministry of Education (VEGA
   1/0307/19) and Ministry of Health (2018/33-LFUK-7) of the Slovak
   Republic and from the Slovak Research and Development Agency
   (APVV-0447-12 and APVV-16-0273).
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NR 78
TC 9
Z9 9
U1 0
U2 7
PU AMER PHYSIOLOGICAL SOC
PI Rockville
PA 6120 Executive Blvd, Suite 600, Rockville, MD, UNITED STATES
SN 1094-8341
EI 1531-2267
J9 PHYSIOL GENOMICS
JI Physiol. Genomics
PD JUL
PY 2021
VL 53
IS 7
BP 309
EP 318
DI 10.1152/physiolgenomics.00029.2021
PG 10
WC Cell Biology; Genetics & Heredity; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Genetics & Heredity; Physiology
GA US3LB
UT WOS:000697333900004
PM 34097532
DA 2025-06-11
ER

PT J
AU Hao, CL
   Lin, HL
   Ke, LY
   Yen, HW
   Shen, KP
AF Hao, Chi-Long
   Lin, Hui-Li
   Ke, Liang-Yin
   Yen, Hsueh-Wei
   Shen, Kuo-Ping
TI Pre-germinated brown rice extract ameliorates high-fat diet-induced
   metabolic syndrome
SO JOURNAL OF FOOD BIOCHEMISTRY
LA English
DT Article
DE glucose; insulin; lipid; metabolic syndrome; pre-germinated brown rice
   extract
ID FISH-OIL; GLUCOSE-METABOLISM; INSULIN-RESISTANCE; ENERGY-EXPENDITURE;
   OXIDATIVE STRESS; CHOLESTEROL; FIBER; HYPERLIPIDEMIA; INFLAMMATION;
   MECHANISMS
AB This study examined the effect of pre-germinated brown rice extract (PGBRE), containing no dietary fibers, but gamma-oryzanol, gamma-aminobutyric acid (GABA), flavonoids, and anthocyanidin, on high-fat-diet (HFD)-induced metabolic syndrome. C57BL/6 mice were divided into five groups: regular diet, HFD, HFD with oral PGBRE 30, 300, or 600 mg/kg per day for 18 weeks. In the HFD group, higher body and liver weight gain, hyperglycemia, HbA1c, and insulin; higher TG, TC, LDL-C, non-HDL, atherosclerosis index, lower HDL, adiponectin in blood; higher TG in the liver; higher TG, bile acid in feces; and lower protein levels of AMP-activated protein kinase, insulin receptor, insulin receptor substrate-1, insulin receptor substrate-2, peroxisome proliferator-activated receptor-gamma, phosphatidylinositol-3-kinase, Akt/PKB, glucose transporter-1, glucose transporter-4, glucokinase in the skeletal muscle; lower glucagon-like peptide 1 (GLP-1) in the intestine; higher sterol regulatory element-binding protein-1 (SREBP-1), stearoyl-CoA desaturase 1 (SCD-1), fatty acid synthase (FAS), 3-hydroxy-3-methylglutaryl-CoA reductase, proprotein convertase subtilisin/kexin type 9 (PCSK9), and lower PPAR-alpha, low-density lipoprotein receptor, cholesterol-7 alpha-hydroxylase in the liver; higher SREBP-1, SCD-1, FAS, and lower PPAR-alpha, adiponectin in the adipose tissue were found. In HFD + PGBRE groups, the above biochemical parameters were improved.
   Practical applications
   According to the results, we suggested that dietary fibers played a minor role in this study. Extract of PGBR, excluding dietary fiber, showed beneficial activity to ameliorate metabolic syndrome. gamma-oryzanol, GABA, flavonoids, and anthocyanidin in PGBRE can inhibit HFD-induced metabolic syndrome and we demonstrated clearly its action mechanisms. This is the first report to examine the relation between PGBRE, GLP-1, and PCSK9. Taken together, PGBRE can potentially be used to develop a good supplement to control metabolic syndrome.
C1 [Hao, Chi-Long] Pingtung Christian Hosp, Dept Internal Med, Div Cardiol, Pingtung, Taiwan.
   [Lin, Hui-Li] Meiho Univ, Dept Food Sci & Nutr, Pingtung, Taiwan.
   [Ke, Liang-Yin] Kaohsiung Med Univ, Lipid Sci & Aging Res Ctr, Kaohsiung, Taiwan.
   [Ke, Liang-Yin] Kaohsiung Med Univ Hosp, Ctr Lipid Biosci, Kaohsiung, Taiwan.
   [Ke, Liang-Yin] Kaohsiung Med Univ, Dept Med Lab Sci & Biotechnol, Kaohsiung, Taiwan.
   [Yen, Hsueh-Wei] Kaohsiung Med Univ Hosp, Div Cardiol, Dept Internal Med, Kaohsiung, Taiwan.
   [Shen, Kuo-Ping] Meiho Univ, Dept Nursing, 23 Ping Kuang Rd, Pingtung 91202, Taiwan.
C3 Kaohsiung Medical University; Kaohsiung Medical University; Kaohsiung
   Medical University Hospital; Kaohsiung Medical University; Kaohsiung
   Medical University; Kaohsiung Medical University Hospital
RP Shen, KP (corresponding author), Meiho Univ, Dept Nursing, 23 Ping Kuang Rd, Pingtung 91202, Taiwan.
EM x00002148@meiho.edu.tw
RI Ke, Liang-Yin/A-2778-2009
OI Ke, Liang-Yin/0000-0002-2547-0987
FU Ministry of Science and Technology; Pingtung Christian Hospital
FX Ministry of Science and Technology; Pingtung Christian Hospital
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NR 34
TC 23
Z9 23
U1 1
U2 23
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0145-8884
EI 1745-4514
J9 J FOOD BIOCHEM
JI J. Food Biochem.
PD MAR
PY 2019
VL 43
IS 3
AR e12769
DI 10.1111/jfbc.12769
PG 11
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA HO6UW
UT WOS:000461068900029
PM 31353547
OA gold
DA 2025-06-11
ER

PT J
AU Icick, R
   Gard, S
   Barde, M
   Carminati, M
   Desage, A
   Guillaume, S
   Scott, J
   Bellivier, F
AF Icick, R.
   Gard, S.
   Barde, M.
   Carminati, M.
   Desage, A.
   Guillaume, S.
   Scott, J.
   Bellivier, F.
CA FondaMental Adv Ctr Expertise Bipo
TI Physical and mental health burden in cases of bipolar disorder
   classified as current, former, or non-tobacco smokers
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Bipolar disorder; Tobacco smoking; Comorbidity; Alcohol and substance
   use disorder; Physical health; Gender
ID MAJOR DEPRESSIVE DISORDER; CIGARETTE-SMOKING; SUICIDAL-BEHAVIOR;
   CARDIOVASCULAR-DISEASE; GENDER-DIFFERENCES; METABOLIC SYNDROME;
   DIABETES-MELLITUS; RISK; SCHIZOPHRENIA; CESSATION
AB Background: Tobacco smoking increases the global burden of bipolar disorder (BD). We examined markers of physical and mental health that are associated with tobacco smoking, controlling for confounders that have not always been considered in previous studies of BD.
   Methods: Over 600 individuals with BD I or II referred to the French Network for bipolar disorder (FACE-BD) who completed standardized assessments, and could be reliably classified as current (CS) or former smokers (FS), were compared with those who were never smokers (NS) on: BD symptom load and psychiatric comorbidities; prevalence of alcohol and substance use disorders (ASUD); medication usage; functioning and physical health parameters. The bivariate and multivariate analyses took into account age and gender.
   Results: 300 cases (49%) were CS, 78 (13%) FS and 238 (39%) had never smoked. Rates were similar across genders regardless of BD subtype. Compared with NS, CS were more likely to have an ASUD (Odds Ratio (OR) 5.18), BD I (OR 2.09), and lower abdominal obesity (OR 0.97), and FS were more likely to have an ASUD (OR 6.32) and higher abdominal obesity (OR 1.03).
   Limitations: The sample comprised of white Europeans; the FS subgroup was relatively small and we did not apply any statistical correction for the bivariate analyses.
   Conclusions: The increased risk of physical and mental health burden in CS and FS compared to NS represents avoidable morbidity in BD. This study offers support to the argument that individuals with BD should be routinely offered support to prevent or stop tobacco smoking.
C1 [Icick, R.; Gard, S.; Barde, M.; Carminati, M.; Guillaume, S.; Bellivier, F.] FondaMental Fdn, F-94000 Creteil, France.
   [Icick, R.; Bellivier, F.] Paris Diderot Univ, INSERM, UMR S 1144, F-75013 Paris, France.
   [Icick, R.; Bellivier, F.] Paris Descartes Univ, INSERM, UMR S1144, F-75006 Paris, France.
   [Icick, R.; Bellivier, F.] INSERM, U 1144, F-75006 Paris, France.
   [Icick, R.; Barde, M.; Carminati, M.; Bellivier, F.] GH St Louis Lariboisiere F Widal, AP HP, Dept Psychiat & Addict Med, F-75010 Paris, France.
   [Gard, S.; Desage, A.] CH Charles Perrens, F-33076 Bordeaux, France.
   [Guillaume, S.] Univ Montpellier I, INSERM, U1061, Montpellier, France.
   [Guillaume, S.] CH Lapeyronie, F-34000 Montpellier, France.
   [Scott, J.] Newcastle Univ, Inst Neurosci, Acad Psychiat, Newcastle, NSW, Australia.
   [Scott, J.] IPPN, Ctr Affect Disorders, London, England.
C3 Universite Paris Cite; Institut National de la Sante et de la Recherche
   Medicale (Inserm); Institut National de la Sante et de la Recherche
   Medicale (Inserm); Universite Paris Cite; Universite Paris Cite;
   Institut National de la Sante et de la Recherche Medicale (Inserm);
   Assistance Publique Hopitaux Paris (APHP); Universite Paris Cite;
   Hopital Universitaire Lariboisiere-Fernand-Widal - APHP; Hopital
   Universitaire Saint-Louis - APHP; Institut National de la Sante et de la
   Recherche Medicale (Inserm); Universite de Montpellier; Universite de
   Montpellier; CHU de Montpellier; University of Newcastle
RP Icick, R (corresponding author), Hop Fernand Widal, Dept Psychiat & Med Addictol, 200 Rue Faubourg, F-75475 Paris 10, France.
EM romain.icick@aphp.fr
RI Icick, Romain/AAY-7305-2020
OI BELLIVIER, FRANK/0000-0002-3660-6640; Icick, Romain/0000-0002-5078-4048
FU FondaMental Foundation, Creteil, France; Investissements d'Avenir
   Programs [ANR-11-IDEX-0004-02, ANR-10-COHO-10-01]
FX This research was supported by FondaMental Foundation, Creteil, France
   and by the Investissements d'Avenir Programs managed by the Association
   Nationale pour la Recherche (ANR) under references ANR-11-IDEX-0004-02
   and ANR-10-COHO-10-01.
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NR 59
TC 11
Z9 11
U1 0
U2 12
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD JAN 15
PY 2017
VL 208
BP 406
EP 413
DI 10.1016/j.jad.2016.09.022
PG 8
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA EG0OR
UT WOS:000390732600058
PM 27810725
DA 2025-06-11
ER

PT J
AU Rega-Kaun, G
   Kaun, C
   Jaegersberger, G
   Prager, M
   Hackl, M
   Demyanets, S
   Wojta, J
   Hohensinner, PJ
AF Rega-Kaun, G.
   Kaun, C.
   Jaegersberger, G.
   Prager, M.
   Hackl, M.
   Demyanets, S.
   Wojta, J.
   Hohensinner, P. J.
TI Roux-en-Y-Bariatric Surgery Reduces Markers of Metabolic Syndrome in
   Morbidly Obese Patients
SO OBESITY SURGERY
LA English
DT Article
DE Bariatric surgery; Metabolic syndrome; miRNA; Insulin sensitivity;
   Hepatic insulin clearance
ID HEPATIC INSULIN-CLEARANCE; BETA-CELL FUNCTION; GASTRIC BYPASS-SURGERY;
   WEIGHT-LOSS; RESISTANCE; PROINSULIN; PLASMA; SENSITIVITY; MIRNA;
   POPULATION
AB Background Obesity is closely linked to increased markers of metabolic syndrome and development of diabetes. Roux-en-Y bariatric surgery reduces hyperinsulinemia and improves insulin sensitivity and hence benefits morbidly obese patients. Aim To determine changes in markers of metabolic syndrome, pancreatic function, and hepatic insulin sensitivity in patients before and 1 year after undergoing Roux-en-Y gastric bypass surgery. Methods We enrolled 43 consecutive patients in a single center. Markers for metabolic syndrome included proinsulin, insulin, C-peptide, liver enzymes, and serum levels of selected microRNAs hsa-miR-122, hsa-miR-130, hsa-miR-132, and hsa-miR-375. Results After surgery, all patients showed a significant 37% drop of body mass index (p < 0.001). Furthermore, proinsulin (59% reduction, p < 0.001), insulin (76% reduction, p < 0.001), and C-peptide (56% reduction, p < 0.001) were all reduced 1 year after surgery. Using the hepatic insulin clearance score, we determined a significant increase in hepatic insulin clearance after surgery (76% increase, p < 0.001). Especially diabetic patients showed a marked 2.1-fold increase after surgery. Hepatic enzymes ALT (35% reduction, p = 0.002) and gamma GT (48% reduction, p < 0.001) were significantly reduced in all patients with similar improvement in diabetic and non-diabetic patients. miRNAs hsa-miR-122, hsa-miR-130, and hsa-miR-132 were all significantly reduced whereas hsa-miR-375 was increased after gastric bypass surgery (p < 0.001 for all miRNAs). Conclusion Both liver and pancreatic stress parameters were reduced significantly 1 year after Roux-en-Y gastric bypass surgery suggesting an overall amelioration of the metabolic syndrome in all patients regardless of previous health status.
C1 [Rega-Kaun, G.; Kaun, C.; Jaegersberger, G.; Demyanets, S.; Wojta, J.; Hohensinner, P. J.] Med Univ Vienna, Div Cardiol, Dept Internal Med 2, Waehringer Guertel 18-20, A-1090 Vienna, Austria.
   [Rega-Kaun, G.] Wilhelminenhospital, Med Dept Endocrinol & Rheumatol 5, Vienna, Austria.
   [Jaegersberger, G.; Wojta, J.; Hohensinner, P. J.] Ludwig Boltzmann Inst Cardiovasc Res, Vienna, Austria.
   [Prager, M.] Hosp Hietzing, Dept Surg, Vienna, Austria.
   [Prager, M.] Hosp Oberwart, Dept Surg, Oberwart, Austria.
   [Hackl, M.] TAmiRNA GmbH, Vienna, Austria.
   [Demyanets, S.] Med Univ Vienna, Dept Lab Med, Vienna, Austria.
   [Wojta, J.] Med Univ Vienna, Core Facil, Vienna, Austria.
C3 Medical University of Vienna; Wilhelminenspital; Ludwig Boltzmann
   Institute; Hietzing Hospital; Medical University of Vienna; Medical
   University of Vienna
RP Wojta, J (corresponding author), Med Univ Vienna, Div Cardiol, Dept Internal Med 2, Waehringer Guertel 18-20, A-1090 Vienna, Austria.; Wojta, J (corresponding author), Ludwig Boltzmann Inst Cardiovasc Res, Vienna, Austria.; Wojta, J (corresponding author), Med Univ Vienna, Core Facil, Vienna, Austria.
EM gersina.rega-kaun@meduniwien.ac.at; christoph.kaun@meduniwien.ac.at;
   gerlinde.jaegersberger@meduniwien.ac.at; manfred.prager@wienkav.at;
   matthias.hackl@tamirna.com; svitlana.demyanets@meduniwien.ac.at;
   johann.wojta@meduniwien.ac.at; philipp.hohensinner@meduniwien.ac.at
RI Kaun, Christoph/L-7543-2015; Wojta, Johann/AAC-8433-2020
OI Hohensinner, Philipp/0000-0003-4819-3190; Rega-Kaun,
   Gersina/0000-0002-3110-481X; Wojta, Johann/0000-0002-1282-9276
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   Wickremesekera K, 2005, OBES SURG, V15, P474, DOI 10.1381/0960892053723402
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NR 49
TC 17
Z9 18
U1 0
U2 10
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0960-8923
EI 1708-0428
J9 OBES SURG
JI Obes. Surg.
PD FEB
PY 2020
VL 30
IS 2
BP 391
EP 400
DI 10.1007/s11695-019-04190-y
PG 10
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA KJ3EX
UT WOS:000511941000002
PM 31728904
OA hybrid
DA 2025-06-11
ER

PT J
AU Mukherjee, A
   Mehta, BK
   Sen, KK
   Banerjee, S
AF Mukherjee, Aniruddha
   Mehta, Bina K.
   Sen, Kalyan K.
   Banerjee, Sugato
TI Metabolic syndrome-associated cognitive decline in mice: Role of
   minocycline
SO INDIAN JOURNAL OF PHARMACOLOGY
LA English
DT Article
DE Cognition; learning and memory metabolic syndrome; minocycline;
   neuroinflammation
ID INFLAMMATION; DEPRESSION; ACTIVATION; EXPRESSION; DISORDER; PROTECTS;
   MEMORY; MODEL
AB OBJECTIVE: The objective of the study was to characterize the mechanism associated with metabolic syndrome (MetS)-associated cognitive decline and determine the effect of minocycline on the above condition in mice.
   MATERIALS AND METHODS: We developed a HFHC diet-induced MetS model in mice. Diagnostic characteristics of MetS including waist circumference, lipid levels, blood pressure, and fasting blood glucose were measured in these Swiss albino mice. Cognitive parameters were measured using passive avoidance and elevated plus maze test. Hippocampal acetylcholine esterase (AchE), reduced glutathione (GSH), and cytokine levels were measured and histopathological evaluation conducted. The MetS animals were administered minocycline (50 mg/kg; 10 days) and the above parameters were measured.
   RESULTS: We successfully induced MetS using HFHC diet in mice. Animals showed significantly higher fasting blood glucose levels (P < 0.001), systolic blood pressure (P < 0.01), waist circumference (P<0.001), low-density lipoprotein (P<0.001), and triglyceride (P<0.01) and reduced high density lipoprotein levels (P < 0.05) compared to control animals. Both scopolamine and MetS significantly lowered (P < 0.01) step-down latency and increased transfer latency (P < 0.001). MetS animals showed significantly higher AchE (P < 0.001) and tumor necrosis factor-alpha (P < 0.001) and lnterleukin-1 beta (P < 0.01) and lower GSH (P < 0.001) levels and reduced both CA1 (P < 0.001) and CA3(P<0.01) neuronal density compared to controls. Minocycline treatment partially reversed the above neurobehavioral and biochemical changes and improved hippocampal neuronal density in MetS animals.
   CONCLUSION: MetS led to hippocampal oxidative stress and neuroinflammatory changes with a corresponding loss of hippocampal neuronal density and cognitive decline. Anti-inflammatory and antioxidant property of minocycline may be responsible for its neuroprotective actions in these animals.
C1 [Mukherjee, Aniruddha; Sen, Kalyan K.] Gupta Coll Technol Sci, Dept Pharmacol, Asansol, W Bengal, India.
   [Mehta, Bina K.; Banerjee, Sugato] Birla Inst Technol, Dept Pharmaceut Sci & Technol, Ranchi, Bihar, India.
C3 Birla Institute of Technology Mesra
RP Banerjee, S (corresponding author), Birla Inst Technol, Dept Pharmaceut Sci & Technol, Ranchi, Bihar, India.
EM sbanerjee@bitmesra.ac.in
RI Mukherjee, Aniruddha/S-7889-2019; Sen, Kalyan/F-2048-2017; BANERJEE,
   SUGATO/L-9012-2019; BANERJEE, SUGATO/M-7317-2017
OI BANERJEE, SUGATO/0000-0002-4402-3066; Mukherjee,
   Aniruddha/0009-0005-8397-6061; sen, kalyan kumar/0000-0003-1914-9238
FU Department of Pharmaceutical Sciences and Technology, BIT, Mesra
FX Thanks are due to Professor Late Debesh Chandra Majumdar, Chairman,
   Trinity Trust, Gupta College of Technological Sciences, Asansol, for his
   support and encouragement. We are also thankful to Dr. S Samanta
   Professor and Head Department of Pharmaceutical Sciences and Technology,
   BIT, Mesra, for his support.
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NR 35
TC 12
Z9 13
U1 0
U2 1
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, Maharashtra, INDIA
SN 0253-7613
EI 1998-3751
J9 INDIAN J PHARMACOL
JI Indian J. Pharmacol.
PD MAR-APR
PY 2018
VL 50
IS 2
BP 61
EP 68
DI 10.4103/ijp.IJP_110_18
PG 8
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA GO7DX
UT WOS:000440218100002
PM 30100653
OA Green Published
DA 2025-06-11
ER

PT J
AU Cizza, G
   Eskandari, F
   Coyle, M
   Krishnamurthy, P
   Wright, EC
   Mistry, S
   Csako, G
AF Cizza, G.
   Eskandari, F.
   Coyle, M.
   Krishnamurthy, P.
   Wright, E. C.
   Mistry, S.
   Csako, G.
CA POWER Premenopausal Osteoporosis
TI Plasma CRP Levels in Premenopausal Women with Major Depression: A
   12-Month Controlled Study
SO HORMONE AND METABOLIC RESEARCH
LA English
DT Article
DE obesity; women's health; inflammation; cytokine; cardiovascular
   morbidity; metabolic syndrome
ID C-REACTIVE PROTEIN; CORONARY-HEART-DISEASE; ACUTE-PHASE PROTEINS;
   CARDIOVASCULAR-DISEASE; SERUM-LEVELS; INFLAMMATORY MARKERS; METABOLIC
   SYNDROME; DISORDER; RISK; ASSOCIATION
AB C-reactive protein (CRP), an inflammatory marker of cardiovascular risk, is often elevated in major depressive disorder (MDD). The magnitude and consistency of this elevation have not been previously characterized in premenopausal women with MDD. The aim of the study was to prospectively assess plasma CRP levels, body composition, endocrine and metabolic parameters, and depressive status in premenopausal women with MDD (n=77) and controls (n=41), aged 21 to 45. Women were enrolled ill a 12-month, controlled study of bone turnover, the P.O.W.E.R. (Premenopausal, Osteoporosis, Women, Alendronate, Depression) Study. Blood samples were taken at Baseline, Month 6, and Month 12. Most subjects with MDD were in clinical remission. These women tended to have consistently higher CRP levels than controls over 12 months (p=0.077). BMI was positively related to log[CRP] in women with MDD only. Nine women with MDD had CRP levels greater than 10mg/l, a value associated with a very high cardiovascular risk. This subset was obese and had significantly higher triglycerides, total cholesterol, LDL-cholesterol, fasting insulin, and HOMA-IR than the rest of women with MDD. The variations in CRP levels over time were high (intra- and inter-individual coefficients of variations of similar to 30-50% and similar to 70-140%, respectively). No control had CRP levels greater than 10mg/l. Depression was associated with increased plasma CRP in women with MDD. The clinical significance of abnormal plasma CRP for cardiovascular risk needs to be assessed in large prospective studies of women with depression.
C1 [Cizza, G.; Coyle, M.; Krishnamurthy, P.; Mistry, S.] NIDDK, Clin Endocrine Sect, Clin Endocrinol Branch, NIH,DHHS, Bethesda, MD USA.
   [Eskandari, F.] NIMH, Sect Neuroendocrine Immunol & Behav, Integrat Neural Immune Program, NIH,DHHS, Bethesda, MD 20892 USA.
   [Csako, G.] NIH, Dept Lab Med, Ctr Clin, DHHS, Bethesda, MD 20892 USA.
C3 National Institutes of Health (NIH) - USA; NIH National Institute of
   Diabetes & Digestive & Kidney Diseases (NIDDK); National Institutes of
   Health (NIH) - USA; NIH National Institute of Mental Health (NIMH);
   National Institutes of Health (NIH) - USA; NIH Clinical Center (CC)
RP Cizza, G (corresponding author), Bldg 10,CRC Rm 6-3940, Bethesda, MD 20892 USA.
EM cizzag@intra.niddk.nih.gov
RI Coyle, Mhairi/A-1844-2010; Mistry, Sejal/JCD-7746-2023; Stefanadis,
   Christodoulos/ABH-2232-2020
OI Stefanadis, Christodoulos/0000-0001-5974-6454
FU National Institute of Mental Health; National Institute of Diabetes,
   Digestive and Kidney Diseases; Clinical Center of the National
   Institutes of Health; DHHS in Bethesda, MD
FX This research was supported in part by the Intramural Research Programs
   of the National Institute of Mental Health, the National Institute of
   Diabetes, Digestive and Kidney Diseases, and the Clinical Center of the
   National Institutes of Health, DHHS in Bethesda, MD. We would like to
   thank all the Subjects participating in this study and Mr. Rene Costello
   for performing CRP assays. The following individuals were investigators
   of the P.O.W.E.R. Protocol (Premenopausal, Osteoporosis, Women,
   Alendronate, Depression): Giovanni Cizza (Principal Investigator) and,
   alphabetically, Anne Berger, Marc R. Blackman, Karim A. Calis, Gyorgy
   Csako, Bart Drinkard, Farideh Eskandari, Philip W. Gold, McDonald Horne,
   Christine Kotila, Pedro Martinez, Kate Musallarn, Terry M. Phillips,
   James. C. Reynolds, Nancy G. Sebring, Esther Sternberg, and Sara Torvik
   (Associate Investigators).
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NR 51
TC 22
Z9 24
U1 0
U2 13
PU GEORG THIEME VERLAG KG
PI STUTTGART
PA RUDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0018-5043
EI 1439-4286
J9 HORM METAB RES
JI Horm. Metab. Res.
PD AUG
PY 2009
VL 41
IS 8
BP 641
EP 648
DI 10.1055/s-0029-1220717
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 486RS
UT WOS:000269216000011
PM 19408214
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Andersen, CJ
   Murphy, KE
   Fernandez, ML
AF Andersen, Catherine J.
   Murphy, Kelsey E.
   Fernandez, Maria Luz
TI Impact of Obesity and Metabolic Syndrome on Immunity
SO ADVANCES IN NUTRITION
LA English
DT Review
ID HIGH-FAT DIET; HIGH-DENSITY-LIPOPROTEIN; ENDOPLASMIC-RETICULUM STRESS;
   T-CELL RECRUITMENT; ADIPOSE-TISSUE; INSULIN-RESISTANCE; CALORIC
   RESTRICTION; PERIPHERAL-BLOOD; MONONUCLEAR-CELLS; OXIDATIVE STRESS
AB Obesity is associated with metabolic disturbances that cause tissue stress and dysfunction. Obese individuals are at a greater risk for chronic disease and often present with clinical parameters of metabolic syndrome (MetS), insulin resistance, and systemic markers of chronic low-grade inflammation. It has been well established that cells of the immune system play an important role in the pathogenesis of obesity-and MetS-related chronic diseases, as evidenced by leukocyte activation and dysfunction in metabolic tissues such as adipose tissue, liver, pancreas, and the vasculature. However, recent findings have highlighted the substantial impact that obesity and MetS parameters have on immunity and pathogen defense, including the disruption of lymphoid tissue integrity; alterations in leukocyte development, phenotypes, and activity; and the coordination of innate and adaptive immune responses. These changes are associated with an overall negative impact on chronic disease progression, immunity from infection, and vaccine efficacy. This review presents an overview of the impact that obesity and MetS parameters have on immune system function.
C1 [Andersen, Catherine J.; Murphy, Kelsey E.] Fairfield Univ, Dept Biol, Fairfield, CT 06430 USA.
   [Fernandez, Maria Luz] Univ Connecticut, Dept Nutr Sci, Storrs, CT USA.
C3 Fairfield University; University of Connecticut
RP Andersen, CJ (corresponding author), Fairfield Univ, Dept Biol, Fairfield, CT 06430 USA.
EM candersen@fairfield.edu
OI Andersen, Catherine/0000-0001-9774-5030
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NR 129
TC 460
Z9 487
U1 5
U2 70
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 2161-8313
EI 2156-5376
J9 ADV NUTR
JI Adv. Nutr.
PD JAN
PY 2016
VL 7
IS 1
BP 66
EP 75
DI 10.3945/an.115.010207
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA DC3HX
UT WOS:000369111500007
PM 26773015
OA hybrid, Green Published
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Fond, G
   Micoulaud-Franchi, JA
   Faugere, M
   Boyer, L
   Faget-Agius, C
   Lancon, C
   Richieri, R
   Cermolacce, M
AF Fond, G.
   Micoulaud-Franchi, J. A.
   Faugere, M.
   Boyer, L.
   Faget-Agius, C.
   Lancon, C.
   Richieri, R.
   Cermolacce, M.
TI Abnormal C-reactive protein blood levels as a specific biomarker of
   major depression and non-remission under antidepressants in
   schizophrenia
SO PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
LA English
DT Article
DE Inflammation; Schizophrenia; Major depression; Antidepressant; Biomarker
ID PERIPHERAL INFLAMMATION; NICOTINE DEPENDENCE; METABOLIC SYNDROME;
   SYMPTOMS; MEDICATION; SCALE
AB Background: C-reactive protein (CRP) is a general marker of peripheral inflammation and has been shown to be a good marker of neuroinflammation. CRP has been found to be elevated in patients with mood disorders (especially unipolar disorders (UD) and in schizophrenia (SZ)) but also to be lowered by antidepressants.
   Objective: The objectives were (i) to determine the prevalence of major depression, antidepressant prescription and remission under antidepressant in a stabilized population of SZ and UD patients consulting in a daily hospital, and (ii) to determine if CRP was a marker of major depression and remission under antidepressant in these SZ and UD populations.
   Methods: Abnormal CRP was defined by a CRP blood level >= 3 mg/L. Depressive symptoms were assessed by the Calgary Depression Rating Scale score. The clinicians were blinded of the CRP status of the patient.
   Results: 411 patients were included (272 SZ and 139 UD). 171 (41.6%) were diagnosed with current major depression (74 (27.2%) for SZ and 97 (69.8%) for UD). 86 SZ (31.6%) and 119 UD (85.6%) were treated by antidepressant. Only 28/74 (37.8%) of the SZ subjects with major depression were administered antidepressants vs. 87/97 (89.7%) for UD. The non-remission rate under antidepressant was 28/86(32.6%) for SZ and 87/119 (73.1%) for UD. Overall, 105 (40.1%) of SZ and 39 (28.1%) of UD patients were found to have abnormal CRP blood levels. Abnormal CRP levels were significantly associated with increased MDD and more strongly with increased rates of non-remission under antidepressants in SZ patients, independently of age, gender, psychotic symptomatology, functioning, tobacco smoking and metabolic syndrome. This result was not replicated in UD patients, which suggests that CRP may be a specific marker of major depression and remission under antidepressant in SZ patients.
   Conclusion: The development of biomarkers in psychiatry may orientate specific etiologic therapies in patients with mental disorders. The present findings suggest that major depression is frequent in SZ patients and that increased CRP levels are associated with non-remission under antidepressants in this population. Anti-inflammatory strategies may be particularly useful in this specific population.
C1 [Fond, G.; Micoulaud-Franchi, J. A.; Faugere, M.; Boyer, L.; Faget-Agius, C.; Lancon, C.; Richieri, R.] La Conception Univ Hosp, Dept Psychiat, F-13005 Marseille, France.
   [Fond, G.; Faugere, M.; Boyer, L.; Faget-Agius, C.; Lancon, C.; Richieri, R.] CEReSS, Hlth Serv Res & Qual Life Ctr, EA 3279, 27 Blvd Jean Moulin, F-13005 Marseille, France.
   [Micoulaud-Franchi, J. A.; Cermolacce, M.] St Marguerite Univ Hosp, SHU Adult Psychiat, F-13274 Marseille, France.
   [Cermolacce, M.] Aix Marseille Univ, Inst Neurosci Syst, INSERM UMR 1106, Marseilles, France.
C3 Aix-Marseille Universite; Aix-Marseille Universite; Aix-Marseille
   Universite; Assistance Publique-Hopitaux de Marseille; Institut National
   de la Sante et de la Recherche Medicale (Inserm); Aix-Marseille
   Universite
RP Fond, G (corresponding author), Aix Marseille Univ, AP HM, Fac Med, Sect Timone,EA 3279,CEReSS Ctr Etud & Rech Serv S, 27 Blvd Jean Moulin, F-13005 Marseille, France.
EM guillaume.fond@ap-hm.fr
RI Fond, Guillaume/D-7646-2011; richieri, raphaelle/E-4707-2015; Faugere,
   Melanie/JCP-3459-2023; Boyer, Laurent/E-5728-2016
OI Faugere, Melanie/0000-0001-5567-8650; RICHIERI,
   Raphaelle/0000-0002-3901-7016; Boyer, Laurent/0000-0003-1229-6622
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NR 33
TC 8
Z9 9
U1 0
U2 101
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0278-5846
EI 1878-4216
J9 PROG NEURO-PSYCHOPH
JI Prog. Neuro-Psychopharmacol. Biol. Psychiatry
PD MAR 8
PY 2020
VL 97
AR 109800
DI 10.1016/j.pnpbp.2019.109800
PG 7
WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA JS8RZ
UT WOS:000500570400017
PM 31676465
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Westman, J
   Eberhard, J
   Gaughran, FP
   Lundin, L
   Stenmark, R
   Edman, G
   Eriksson, SV
   Jedenius, E
   Rydell, P
   Overgaard, K
   Abrams, D
   Greenwood, KE
   Smith, S
   Ismail, K
   Murray, R
   Ösby, U
AF Westman, Jeanette
   Eberhard, Jonas
   Gaughran, Fiona P.
   Lundin, Lennart
   Stenmark, Richard
   Edman, Gunnar
   Eriksson, Sven V.
   Jedenius, Erik
   Rydell, Pia
   Overgaard, Karin
   Abrams, Daniel
   Greenwood, Kathryn E.
   Smith, Shubulade
   Ismail, Khalida
   Murray, Robin
   Osby, Urban
TI Outcome of a psychosocial health promotion intervention aimed at
   improving physical health and reducing alcohol use in patients with
   schizophrenia and psychotic disorders (MINT)
SO SCHIZOPHRENIA RESEARCH
LA English
DT Article
DE Cardiovascular risk factors; lifestyle intervention; Psychiatric care;
   Mental health; Psychosis; Run-in period
ID CARDIOVASCULAR RISK-FACTORS; LIFE-STYLE INTERVENTIONS; SERIOUS
   MENTAL-ILLNESS; INDIVIDUALS; OBESITY; ADULTS; ASSOCIATION; EXERCISE;
   SMOKING; DISEASE
AB Background: Life expectancy is reduced by 19 years in men and 17 in women with psychosis in Sweden, largely due to cardiovascular disease.
   Aim: Assess whether a psychosocial health promotion intervention improves cardiometabolic risk factors, quality of life, and severity of illness in patients with psychotic disorders more than treatment as usual.
   Methods: A pragmatic intervention trial testing a manual-based multi-component health promotion intervention targeting patients with psychosis. The Swedish intervention was adapted from IMPaCT therapy, a health-promotion program based on motivational interviewing and cognitive behavioral therapy, designed to be incorporated into routine care. The intervention group consisted of 119 patients and the control group of 570 patients from specialized psychosis departments. Outcome variables were assessed 6 months before intervention during the run-in period, again at the start of intervention, and 12 months after the intervention began. The control group received treatment as usual.
   Results: The intervention had no significant effect on any of the outcome variables. However, BMI, waist circumference, systolic BP, heart rate, HbA1c, general health, and Clinical Global Impressions Scale score improved significantly during the run-in period before the start of the active intervention (observer effect). The multi-component design meant that treatment effects could only be calculated for the intervention as a whole.
   Conclusion: The results of the intervention are similar to those of the U.K. IMPaCT study, in which the modular health-promotion intervention had little effect on cardiovascular risk indicators. However, in the current study, the run-in period had a positive effect on cardiometabolic risk factors. (C) 2019 Published by Elsevier B.V.
C1 [Westman, Jeanette; Jedenius, Erik] Karolinska Inst, Dept Neurobiol Care Sci & Soc, Stockholm, Sweden.
   [Westman, Jeanette] Acad Primary Hlth Care Cenire, Reg Stockholm, Sweden.
   [Eberhard, Jonas; Stenmark, Richard; Jedenius, Erik] Lund Univ, Dept Clin Sci, Div Psychiat, Lund, Sweden.
   Kings Coll London, Inst Psychiat Psychol & Neurosci, London, England.
   [Gaughran, Fiona P.; Smith, Shubulade; Murray, Robin] South London & Maudsley NHS Fdn Trust, London, England.
   [Lundin, Lennart; Overgaard, Karin; Abrams, Daniel] Sahlgrens Univ Hosp, Gothenburg, Sweden.
   [Edman, Gunnar] Tiohundra AB, Norrtalje Hosp, Norrtalje, Sweden.
   [Edman, Gunnar] Karolinska Inst, Danderyd Hosp, Dept Clin Sci, Stockholm, Sweden.
   [Eriksson, Sven V.] Enkoping Hosp, Dept Internal Med, Enkoping, Sweden.
   [Eriksson, Sven V.] Aleris Specialist Care, Gothenburg, Sweden.
   [Greenwood, Kathryn E.] Univ Sussex, Sch Psychol, Brighton, E Sussex, England.
   [Greenwood, Kathryn E.] Sussex Partnership NHS Fdn Trust, Worthing, W Sussex, England.
   [Osby, Urban] Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden.
   [Osby, Urban] Karolinska Univ Hosp, Ctr Mol Med, Stockholm, Sweden.
C3 Karolinska Institutet; Lund University; University of London; King's
   College London; South London & Maudsley NHS Trust; Sahlgrenska
   University Hospital; Karolinska Institutet; Danderyds Hospital;
   University of Sussex; Karolinska Institutet; Karolinska Institutet;
   Karolinska University Hospital
RP Westman, J (corresponding author), Karolinska Inst, Dept Neurobiol Care Sci & Soc, Alfred Nobels Alle 23, Huddinge, Sweden.
EM jeanette.westman@ki.se
RI Gaughran, Fiona/AAC-7160-2019; Eriksson, Sven/A-9391-2017; greenwood,
   kathryn/I-8638-2012; Gaughran, Fiona/H-5495-2011; murray,
   robin/F-8658-2012
OI Jedenius, Erik/0000-0003-3828-8938; Gaughran, Fiona/0000-0001-7414-5569;
   Smith, Shubulade/0000-0002-3797-6985; Greenwood,
   Kathryn/0000-0001-7899-8980; Ismail, Khalida/0000-0001-6084-449X;
   Eriksson, Sven Vilhelm/0000-0002-1426-3894; murray,
   robin/0000-0003-0829-0519; Westman, Jeanette/0000-0001-8701-4226
FU FORTE [2013-1312]; Stockholm County Council (ALF) [20150255]
FX This work was supported by grants to Dr. J Westman from FORTE (Dnr
   2013-1312) and the Stockholm County Council (ALF) (Dnr 20150255).
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NR 37
TC 7
Z9 8
U1 0
U2 18
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0920-9964
EI 1573-2509
J9 SCHIZOPHR RES
JI Schizophr. Res.
PD JUN
PY 2019
VL 208
BP 138
EP 144
DI 10.1016/j.schres.2019.03.026
PG 7
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA HZ7GQ
UT WOS:000469022400022
PM 30979666
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Shen, JH
   Ma, Q
   Shen, SG
   Xu, GT
   Das, UN
AF Shen, Jun-hui
   Ma, Qi
   Shen, Shen-grong
   Xu, Guo-Tong
   Das, Undurti N.
TI Effect of α-Linolenic Acid on Streptozotocin-induced Diabetic
   Retinopathy Indices In Vivo
SO ARCHIVES OF MEDICAL RESEARCH
LA English
DT Article
DE alpha-Linolenic acid; Diabetic retinopathy; Polyunsaturated fatty acids;
   BDNF; VEGF; Interleulcin-6
ID ENDOTHELIAL GROWTH-FACTOR; POLYUNSATURATED FATTY-ACIDS; ALLOXAN-INDUCED
   CYTOTOXICITY; METABOLIC SYNDROME-X; TNF-ALPHA; FACTOR EXPRESSION;
   GENE-EXPRESSION; VEGF PRODUCTION; TUMOR-GROWTH; CELLS
AB Background and Aims. Both oxidative stress and inflammation play a significant role in the pathobiology of diabetic retinopathy. Increased consumption of polyunsaturated fatty acids (PUFAs) may prevent or postpone the occurrence of diabetic retinopathy. Hence, the effect of alpha-linolenic acid (ALA), an essential fatty acid, on oxidative stress, inflammatory indices and production of vascular endothelial growth factor (VEGF) in streptozotocin-induced diabetic retinopathy indices in vivo was studied.
   Methods. Serum and retina concentrations of vascular endothelial growth factor (VEGF), brain-derived neurotrophic factor (BDNF), interleukin-6 (IL-6), plasma and retina concentrations of lipid peroxides and antioxidant enzymes were estimated in streptozotocin (STZ)-induced diabetic animals.
   Results. STZ-induced diabetic rats had significantly higher levels of VEGF in the serum and retina and IL-6 in the serum, whereas BDNF was lower in the serum, all of which reverted to near normal in ALA-treated diabetic animals. STZ treatment decreased serum glutathione peroxidase levels, which was restored to normal by both pre- and post-ALA treatment groups.
   Conclusions. STZ-induced changes in serum glutathione peroxidase, BDNF, VEGF and IL-6 that reverted to near control by ALA treatment, especially in ALA + STZ group, lending support to the concept that both oxidative stress and inflammation participate in DR and ALA treatment is of benefit in its prevention. (C) 2013 IMSS. Published by Elsevier Inc.
C1 [Shen, Jun-hui] Tongji Univ, Sch Med, Tongji Eye Inst, Lab Clin Visual Sci, Shanghai 200092, Peoples R China.
   [Shen, Jun-hui; Ma, Qi; Shen, Shen-grong] Zhejiang Univ, Sch Biosyst Engn & Food Sci, Dept Food Sci & Nutr, Hangzhou 310003, Zhejiang, Peoples R China.
   [Xu, Guo-Tong] Tongji Univ, Shanghai Peoples Hosp 10, Dept Ophthalmol, Sch Med, Shanghai 200092, Peoples R China.
   [Xu, Guo-Tong] Tongji Univ, Lab Clin Visual Sci, Tongji Eye Inst, Sch Med, Shanghai 200092, Peoples R China.
   [Das, Undurti N.] UND Life Sci, Washington, DC USA.
   [Das, Undurti N.] Jawaharlal Nehru Technol Univ, Sch Biotechnol, Kakinada, India.
   [Das, Undurti N.] Gayatri Vidya Parishad Coll Engn, Biosci Res Ctr, Visakhapatnam, Andhra Pradesh, India.
C3 Tongji University; Zhejiang University; Tongji University; Tongji
   University; Jawaharlal Nehru Technological University - Kakinada;
   Gayatri Vidya Parishad College of Engineering
RP Das, UN (corresponding author), UND Life Sci, 13800 Fairhill Rd,321, Shaker Hts, OH 44120 USA.
EM undurti@hotmail.com
RI Das, Undurti/A-7918-2009
FU SITP of Tongji University and Shanghai Undergraduate Student Innovation
   [1500-107-043]; Ramalingaswami Fellowship of the Department of
   Biotechnology, New Delhi; Department of Science and Technology
   [IR/SO/LU/03/2008/1]
FX This project was supported by SITP of Tongji University and Shanghai
   Undergraduate Student Innovation Project (No.1500-107-043). UND is in
   receipt of Ramalingaswami Fellowship of the Department of Biotechnology,
   New Delhi during the tenure of this study. This study was funded, in
   part, by a grant from the Department of Science and Technology to UND
   (No. IR/SO/LU/03/2008/1) under Intensification of Research in High
   Priority Areas (IRPHA).
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NR 44
TC 27
Z9 32
U1 0
U2 15
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0188-4409
EI 1873-5487
J9 ARCH MED RES
JI Arch. Med. Res.
PD OCT
PY 2013
VL 44
IS 7
BP 514
EP 520
DI 10.1016/j.arcmed.2013.09.010
PG 7
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 257VR
UT WOS:000327416400005
PM 24120388
DA 2025-06-11
ER

PT J
AU Chang, J
   Oikawa, S
   Ichihara, G
   Nanpei, Y
   Hotta, Y
   Yamada, Y
   Tada-Oikawa, S
   Iwahashi, H
   Kitagawa, E
   Takeuchi, I
   Yuda, M
   Ichihara, S
AF Chang, Jie
   Oikawa, Shinji
   Ichihara, Gaku
   Nanpei, Yui
   Hotta, Yasuhiro
   Yamada, Yoshiji
   Tada-Oikawa, Saeko
   Iwahashi, Hitoshi
   Kitagawa, Emiko
   Takeuchi, Ichiro
   Yuda, Masao
   Ichihara, Sahoko
TI Altered gene and protein expression in liver of the obese spontaneously
   hypertensive/NDmcr-cp rat
SO NUTRITION & METABOLISM
LA English
DT Article
DE Metabolic syndrome; Pathophysiology; Microarray analysis; Proteomics
   analysis; Obesity; Liver
ID METABOLIC SYNDROME; ESTROGEN SULFOTRANSFERASE; CALRETICULIN; RISK;
   SURVIVAL; GLUCOSE; CLONING; HEALTH; HEART; MODEL
AB Background: It is difficult to study the mechanisms of the metabolic syndrome in humans due to the heterogeneous genetic background and lifestyle. The present study investigated changes in the gene and protein profiles in an animal model of the metabolic syndrome to identify the molecular targets associated with the pathogenesis and progression of obesity related to the metabolic syndrome.
   Methods: We extracted mRNAs and proteins from the liver tissues of 6- and 25-week-old spontaneously hypertensive/NIH -corpulent rat SHR/NDmcr-cp (CP), SHR/Lean (Lean) and Wistar Kyoto rats (WKY) and performed microarray analysis and two-dimensional difference in gel electrophoresis (2D-DIGE) linked to a matrix-assisted laser desorption ionization time-of-flight tandem mass spectrometry (MALDI-TOF/TOF MS).
   Results: The microarray analysis identified 25 significantly up-regulated genes (P < 0.01; log(10) > 1) and 31 significantly down-regulated genes (P < 0.01; log(10) < -1) in 6- and 25-week-old CP compared with WKY and Lean. Several of these genes are known to be involved in important biological processes such as electron transporter activity, electron transport, lipid metabolism, ion transport, transferase, and ion channel activity. MALDI-TOF/TOF MS identified 31 proteins with +/- 1.2 fold change (P < 0.05) in 6- and 25-week-old CP, compared with age-matched WKY and Lean. The up-regulated proteins are involved in metabolic processes, biological regulation, catalytic activity, and binding, while the down-regulated proteins are involved in endoplasmic reticulum stress-related unfolded protein response.
   Conclusion: Genes with significant changes in their expression in transcriptomic analysis matched very few of the proteins identified in proteomics analysis. However, annotated functional classifications might provide an important reference resource to understand the pathogenesis of obesity associated with the metabolic syndrome.
C1 [Chang, Jie; Tada-Oikawa, Saeko; Ichihara, Sahoko] Mie Univ, Grad Sch Reg Innovat Studies, Tsu, Mie 5148507, Japan.
   [Chang, Jie; Ichihara, Gaku] Nagoya Univ, Grad Sch Med, Dept Environm & Occupat Hlth, Nagoya, Aichi 4648601, Japan.
   [Oikawa, Shinji] Mie Univ, Grad Sch Med, Dept Mol & Environm Med, Tsu, Mie 5148507, Japan.
   [Nanpei, Yui; Hotta, Yasuhiro; Yamada, Yoshiji; Ichihara, Sahoko] Mie Univ, Life Sci Res Ctr, Dept Human Funct Genom, Tsu, Mie 5148507, Japan.
   [Iwahashi, Hitoshi; Kitagawa, Emiko] Natl Inst Adv Ind Sci & Technol, Hlth Technol Res Ctr, Tsukuba, Ibaraki, Japan.
   [Takeuchi, Ichiro] Nagoya Inst Technol, Dept Engn, Nagoya, Aichi, Japan.
   [Yuda, Masao] Mie Univ, Grad Sch Med, Dept Med Zool, Tsu, Mie 5148507, Japan.
   [Iwahashi, Hitoshi] Gifu Univ, Grad Sch Appl Biol Sci, Gifu, Japan.
   [Kitagawa, Emiko] Roche Diagnost, Appl Sci, Tokyo, Japan.
C3 Mie University; Nagoya University; Mie University; Mie University;
   National Institute of Advanced Industrial Science & Technology (AIST);
   Nagoya Institute of Technology; Mie University; Gifu University; Roche
   Holding; Roche Holding Japan
RP Ichihara, S (corresponding author), Mie Univ, Grad Sch Reg Innovat Studies, 1577 Kurimamachiya Cho, Tsu, Mie 5148507, Japan.
EM saho@gene.mie-u.ac.jp
RI Iwahashi, Hitoshi/S-1360-2019; Chang, Jie/AFR-8580-2022
OI Ichihara, Gaku/0000-0001-5707-5300
FU Japan Society for the Promotion of Science [22390122]; Japan Society for
   the Promotion of Science (NEXT Program) [LS056]; Grants-in-Aid for
   Scientific Research [23890082, 23390162, 22390122] Funding Source: KAKEN
FX The authors thank Kiyora Izuoka for assistance with biochemical analysis
   and Kumi Nakao for help in preparation of the manuscript. This work was
   supported in part by grants from the Japan Society for the Promotion of
   Science (grants-in aid for Scientific Research #22390122 and NEXT
   Program #LS056).
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NR 38
TC 9
Z9 9
U1 0
U2 9
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1743-7075
J9 NUTR METAB
JI Nutr. Metab.
PD SEP 21
PY 2012
VL 9
AR 87
DI 10.1186/1743-7075-9-87
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 084KC
UT WOS:000314536900001
PM 22998770
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Agrawal, S
   Mehta, PK
   Merz, CNB
AF Agrawal, Shilpa
   Mehta, Puja K.
   Merz, C. Noel Bairey
TI Cardiac Syndrome X: Update 2014
SO CARDIOLOGY CLINICS
LA English
DT Article
DE Cardiac syndrome X; Angina; Ischemia; Microvascular endothelial
   dysfunction; Myocardial hypersensitivity
ID NORMAL CORONARY-ARTERIES; CONVERTING ENZYME-INHIBITION; ENHANCED
   EXTERNAL COUNTERPULSATION; CARDIOVASCULAR MAGNETIC-RESONANCE;
   LEFT-VENTRICULAR FUNCTION; CALCIUM-CHANNEL BLOCKER; STABLE
   ANGINA-PECTORIS; CHEST-PAIN; MYOCARDIAL-ISCHEMIA; MICROVASCULAR
   DYSFUNCTION
AB Cardiac Syndrome X (CSX), characterized by angina-like chest discomfort, ST segment depression during exercise, and normal epicardial coronary arteries at angiography, is highly prevalent in women. CSX is not benign, and linked to adverse cardiovascular outcomes and a poor quality of life. Coronary microvascular and endothelial dysfunction and abnormal cardiac nociception have been implicated in the pathogenesis of CSX. Treatment includes life-style modification, anti-anginal, anti-atherosclerotic, and anti-ischemic medications. Non-pharmacological options include cognitive behavioral therapy, enhanced external counterpulsation, neurostimutation, and stellate ganglionectomy. Studies have shown the efficacy of individual treatments but guidelines outlining the best course of therapy are lacking.
C1 [Agrawal, Shilpa] Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90095 USA.
   [Mehta, Puja K.; Merz, C. Noel Bairey] Cedars Sinai Med Ctr, Dept Med, Barbra Streisand Womens Heart Ctr, Cedars Sinai Heart Inst, Los Angeles, CA 90048 USA.
C3 University of California System; University of California Los Angeles;
   University of California Los Angeles Medical Center; David Geffen School
   of Medicine at UCLA; Cedars Sinai Medical Center
RP Mehta, PK (corresponding author), 127 South San Vicente Blvd,Suite A3212, Los Angeles, CA 90048 USA.
EM puja.mehta@cshs.org
OI Bairey Merz, C. Noel/0000-0002-9933-5155
FU National Heart, Lung, and Blood Institute [N01-HV-68161, N01-HV-68162,
   N01-HV-68163, N01-HV-68164]; National Institute on Aging [K23HL105787,
   U0164829, U01 HL649141, U01 HL649241, T32HL69751, R01 HL090957,
   1R03AG032631]; GCRC from the National Center for Research Resources
   [MO1-RR00425]; Gustavus and Louis Pfeiffer Research Foundation,
   Danville, NJ; Women's Guild of Cedars-Sinai Medical Center, Los Angeles,
   CA; Ladies Hospital Aid Society of Western Pennsylvania, Pittsburgh, PA;
   QMED, Laurence Harbor, NJ; Edythe L. Broad Women's Heart Research
   Fellowship, Cedars-Sinai Medical Center, Los Angeles, California; Barbra
   Streisand Women's Cardiovascular Research and Education Program,
   Cedars-Sinai Medical Center, Los Angeles; Linda Joy Pollin Women's Heart
   Health Program, Cedars-Sinai Medical Center, Los Angeles
FX This work was supported by contracts from the National Heart, Lung, and
   Blood Institute, N01-HV-68161, N01-HV-68162, N01-HV-68163, N01-HV-68164,
   grants K23HL105787, U0164829, U01 HL649141, U01 HL649241, T32HL69751,
   R01 HL090957, 1R03AG032631 from the National Institute on Aging, GCRC
   grant MO1-RR00425 from the National Center for Research Resources and
   grants from the Gustavus and Louis Pfeiffer Research Foundation,
   Danville, NJ, The Women's Guild of Cedars-Sinai Medical Center, Los
   Angeles, CA, The Ladies Hospital Aid Society of Western Pennsylvania,
   Pittsburgh, PA, and QMED, Laurence Harbor, NJ, the Edythe L. Broad
   Women's Heart Research Fellowship, Cedars-Sinai Medical Center, Los
   Angeles, California, and the Barbra Streisand Women's Cardiovascular
   Research and Education Program, Cedars-Sinai Medical Center, Los
   Angeles, and the Linda Joy Pollin Women's Heart Health Program,
   Cedars-Sinai Medical Center, Los Angeles.
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NR 112
TC 54
Z9 60
U1 0
U2 8
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0733-8651
EI 1558-2264
J9 CARDIOL CLIN
JI Cardiol. Clin.
PD AUG
PY 2014
VL 32
IS 3
BP 463
EP +
DI 10.1016/j.ccl.2014.04.006
PG 17
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA AO0HD
UT WOS:000340988800012
PM 25091971
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Sohouli, MH
   Fatahi, S
   Sharifi-Zahabi, E
   Santos, HO
   Tripathi, N
   Lari, A
   Pourrajab, B
   Kord-Varkaneh, H
   Gaman, MA
   Shidfar, F
AF Sohouli, Mohammad Hasan
   Fatahi, Somaye
   Sharifi-Zahabi, Elham
   Santos, Heitor O.
   Tripathi, Nishant
   Lari, Abolfazl
   Pourrajab, Behnaz
   Kord-Varkaneh, Hamed
   Gaman, Mihnea-Alexandru
   Shidfar, Farzad
TI The Impact of Low Advanced Glycation End Products Diet on Metabolic Risk
   Factors: A Systematic Review and Meta-Analysis of Randomized Controlled
   Trials
SO ADVANCES IN NUTRITION
LA English
DT Review
DE meta-analysis; dietary advanced glycation end products; randomized
   controlled trails; systematic review; metabolic syndrome
ID INSULIN-RESISTANCE; OXIDATIVE STRESS; ENDOTHELIAL FUNCTION; RESTRICTION;
   IMPROVES; ENDPRODUCTS; DISEASE; AGES; INFLAMMATION; PARAMETERS
AB Several randomized clinical trials have investigated the effect of dietary advanced glycation end products (AGEs) on metabolic syndrome risk factors in adults. However, the results of these studies were conflicting. Therefore, our aim was to assess the effect of dietary AGEs on metabolic syndrome risk factors. We searched the PubMed-MEDLINE, Scopus, Cochrane Databases, Google Scholar, Web of Science, and Embase databases for papers published up to October 2019 that investigated the effect of dietary AGEs on metabolic syndrome risk factors. From the eligible trials, 13 articles were selected for inclusion in this systematic review and meta-analysis. The meta-analysis was performed using a random-effects model. Heterogeneity was determined by I-2 statistics and Cochrane Q test. Pooled results from the random effects model showed a significant reduction for insulin resistance [weighted mean difference (WMD): -1.204; 95% CI: -2.057, -0358; P = 0.006], fasting insulin (WMD: -5.472 mu U/mL; 95% CI: -9.718, -1.234 mu U/mL; P = 0.011), total cholesterol (WMD: -5.486 mg/dL; 95% CI: -10.222, -0.747 mg/dL; P = 0.023), and LDL (WMD: -6.263 mg/dL; 95% CI: -11.659, -0.866 mg/dL; P = 0.023) in the low-AGEs groups compared with the high-AGEs groups. There were no changes in the other components of the metabolic syndrome. The results of this review suggest that a diet with a low AGEs content has beneficial effects on insulin resistance, fasting insulin, total cholesterol, and LDL. Moreover, following a diet low in AGEs may be a helpful strategy to decrease the burden of metabolic syndrome risk fact rs in adults and particularly in patients with diabetes.
C1 [Sohouli, Mohammad Hasan; Fatahi, Somaye; Lari, Abolfazl; Pourrajab, Behnaz] Iran Univ Med Sci, Fac Publ Hlth Branch, Student Res Comm, Tehran, Iran.
   [Sohouli, Mohammad Hasan; Sharifi-Zahabi, Elham; Lari, Abolfazl; Pourrajab, Behnaz; Shidfar, Farzad] Iran Univ Med Sci, Sch Publ Hlth, Dept Nutr, Tehran, Iran.
   [Fatahi, Somaye] Shahid Beheshti Univ Med Sci, Res Inst Childrens Hlth, Pediat Gastroenterol Hepatol & Nutr Res Ctr, Tehran, Iran.
   [Santos, Heitor O.] Univ Fed Uberlandia, Sch Med, Uberlandia, MG, Brazil.
   [Tripathi, Nishant] Univ Kentucky, Coll Med, Lexington, KY USA.
   [Kord-Varkaneh, Hamed] Shahid Beheshti Univ Med Sci, Fac Nutr & Food Technol, Dept Clin Nutr & Dietet, Tehran, Iran.
   [Gaman, Mihnea-Alexandru] Carol Davila Univ Med & Pharm, Bucharest, Romania.
   [Gaman, Mihnea-Alexandru] Fundeni Clin Inst, Ctr Hematol & Bone Marrow Transplantat, Bucharest, Romania.
   [Shidfar, Farzad] Iran Univ Med Sci, Colorectal Res Ctr, Tehran, Iran.
C3 Iran University of Medical Sciences; Iran University of Medical
   Sciences; Shahid Beheshti University Medical Sciences; Universidade
   Federal de Uberlandia; University of Kentucky; Shahid Beheshti
   University Medical Sciences; Carol Davila University of Medicine &
   Pharmacy; Institutul Clinic Fundeni; Iran University of Medical Sciences
RP Shidfar, F (corresponding author), Iran Univ Med Sci, Sch Publ Hlth, Dept Nutr, Tehran, Iran.; Shidfar, F (corresponding author), Iran Univ Med Sci, Colorectal Res Ctr, Tehran, Iran.
EM shidfar.f@iums.ac.ir
RI pourrajab, behnaz/HPG-0715-2023; Tripathi, Nishant/L-8012-2019; Shidfar,
   Farzad/H-6651-2018; Gaman, Mihnea-Alexandru/O-4258-2016
OI Gaman, Mihnea-Alexandru/0000-0001-7133-8875; shidfar,
   Farzad/0000-0002-6531-9253
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NR 38
TC 50
Z9 50
U1 1
U2 16
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 2161-8313
EI 2156-5376
J9 ADV NUTR
JI Adv. Nutr.
PD MAY
PY 2021
VL 12
IS 3
BP 766
EP 776
DI 10.1093/advances/nmaa150
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA SS0XE
UT WOS:000661465200016
PM 33253361
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Tsuneyama, K
   Chen, YC
   Fujimoto, M
   Sasaki, Y
   Suzuki, W
   Shimada, T
   Iizuka, S
   Nagata, M
   Aburada, M
   Chen, SY
AF Tsuneyama, Koichi
   Chen, Yen-Chen
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   Suzuki, Wataru
   Shimada, Tsutomu
   Iizuka, Seiichi
   Nagata, Mitsunobu
   Aburada, Masaki
   Chen, Shao-Yuan
TI Advantages and Disadvantages of Hyperbaric Oxygen Treatment in Mice with
   Obesity Hyperlipidemia and Steatohepatitis
SO THESCIENTIFICWORLDJOURNAL
LA English
DT Article
DE Nonalcoholic steatohepatitis; obesity; hyperbaric oxygen treatment; MSG
   mice
ID FATTY LIVER-DISEASE; NONALCOHOLIC STEATOHEPATITIS; ORTHOPEDIC
   CONDITIONS; MONOSODIUM GLUTAMATE; METABOLIC SYNDROME; DIABETES-MELLITUS;
   OXIDATIVE STRESS; THERAPY; 8-HYDROXYDEOXYGUANOSINE; PIOGLITAZONE
AB The effect of hyperbaric oxygen treatment (HBOT) was examined using MSG mice, which are an animal model of obesity, hyperlipidemia, diabetes, and nonalcoholic fatty liver disease. Nineteen MSG male mice were divided into HBOT treated and control groups at 12 weeks of ages. The HBOT group was treated with hyperbaric oxygen from 12 to 14 weeks (first phase) and then from 16 to 18 weeks (second phase). Interestingly, the body weight of the HBOT group was significantly lower (P < 0.01) than that of the control group. In contrast, the serum lipid level did not show significant changes between the two groups. As for the effects of increasing oxidative stress, the liver histology of the HBOT group showed severer cellular damage and aberrant TNF-alpha expression. HBOT has the advantage of improving obesity in patients with metabolic syndrome, but the fault of causing organ damage by increasing oxidative stress.
C1 [Chen, Shao-Yuan] Fu Jen Catholic Univ, Sch Med, New Taipei City, Taiwan.
   [Tsuneyama, Koichi] Toyama Univ, Grad Sch Med & Pharmaceut Sci, Dept Diagnost Pathol, Toyama 930, Japan.
   [Chen, Yen-Chen] Natl Def Med Ctr, Dept Microbiol & Immunol, Taipei, Taiwan.
   [Fujimoto, Makoto] Toyama Univ, Grad Sch Med & Pharmaceut Sci, Dept Japanese Oriental Med, Toyama 930, Japan.
   [Sasaki, Yoshiyuki] Inst Anim Reprod, Kasumigaura, Ibaraki 3000134, Japan.
   [Suzuki, Wataru; Shimada, Tsutomu; Iizuka, Seiichi; Nagata, Mitsunobu; Aburada, Masaki] Musashino Univ, Pharmaceut Sci Res Inst, Fac Pharm, Nishitokyo, Tokyo 2028585, Japan.
   [Chen, Shao-Yuan] Cardinal Tien Hosp, Dept Hyperbar Med & Neurol, New Taipei City, Taiwan.
C3 Fu Jen Catholic University; University of Toyama; National Defense
   Medical Center; University of Toyama; Cardinal Tien Hospital
RP Chen, SY (corresponding author), Fu Jen Catholic Univ, Sch Med, New Taipei City, Taiwan.
EM sychen@ndmctsgh.edu.tw
OI Chen, Shao-Yuan/0000-0002-7010-7677; Tsuneyama,
   Koichi/0000-0002-0670-9868
FU Interchange association of JAPAN; Grants-in-Aid for Scientific Research
   [21590433] Funding Source: KAKEN
FX The authors thank Tokimasa Kumada and Takeshi Nishida for their
   technical assistance. This study was supported by a research grant from
   the Interchange association of JAPAN (2008).
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NR 34
TC 20
Z9 22
U1 0
U2 3
PU HINDAWI PUBLISHING CORP
PI NEW YORK
PA 410 PARK AVENUE, 15TH FLOOR, #287 PMB, NEW YORK, NY 10022 USA
SN 1537-744X
J9 THESCIENTIFICWORLDJO
JI TheScientificWorldJOURNAL
PY 2011
VL 11
BP 2124
EP 2135
DI 10.1100/2011/380236
PG 12
WC Environmental Sciences; Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Science & Technology - Other Topics
GA 854SB
UT WOS:000297513400015
PM 22125461
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Lanza, GA
   Andreotti, F
   Sestito, A
   Sciahbasi, A
   Crea, F
   Maseri, A
AF Lanza, GA
   Andreotti, F
   Sestito, A
   Sciahbasi, A
   Crea, F
   Maseri, A
TI Platelet aggregability in cardiac syndrome X
SO EUROPEAN HEART JOURNAL
LA English
DT Article
DE syndrome X; platelet aggregability; exercise; adenosine
ID NORMAL CORONARY ANGIOGRAMS; SODIUM-HYDROGEN EXCHANGE; ANGINA-PECTORIS;
   MYOCARDIAL-ISCHEMIA; MICROVASCULAR ANGINA; STRENUOUS EXERCISE; CHEST
   PAIN; ADENOSINE; AGGREGATION; AMINOPHYLLINE
AB Aims To assess platelet aggregability at rest and in response to exercise in patients with cardiac syndrome X (anginal chest pain, ST-segment depression on exercise. angiographically normal coronary arteries).
   Methods and Results We performed a symptom/sign-limited exercise test in 31 patients with syndrome X, 25 patients with coronary artery disease and 29 healthy subjects, Platelet aggregability was measured in flowing whole blood at baseline. at peak exercise. and after 30 and 120 min. as the time to occlude a collagen/adenosine diphosphate coated ring (aggregation time). Resting aggregation time was shorter in syndrome X patients (83.2 +/- 12 s), compared to patients with coronary disease (94.0 +/- 18 s, P < 0.01) and to healthy subjects (96.4 +/- 21 s, P < 0.01). With exercise, aggregation time did not change in healthy controls. decreased in patients with coronary disease ( -13.8 s at peak: 95%, CI, -10.2, - 17.3 s. P < 0.001). but increased in syndrome X (+17.4 s 30 min after exercise: 95% CI. +10.4. +24.4 s; P < 0.0001). The intravenous administration of an adenosine antagonist (theophylline) prevented the exercise-induced prolongation of aggregation time in syndrome X patients (n = 11), but had no effect in healthy controls (n = 11). Conclusion Platelet aggregability at rest was increased in syndrome X patients. compared to patients with coronary artery disease and healthy subjects. In contrast to patients with coronary disease, however, platelet aggregability was reduced by exercise. This response was prevented by theophylline, strongly suggesting the involvement of adenosine. (C) 2001 The European Society of Cardiology.
C1 Univ Cattolica Sacro Cuore, Ist Cardiol, I-00168 Rome, Italy.
C3 Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli
RP Univ Cattolica Sacro Cuore, Ist Cardiol, Lgo A Gemelli 8, I-00168 Rome, Italy.
RI Lanza, Gaetano/AAC-2660-2019; Andreotti, Felicita/A-9962-2019;
   Sciahbasi, Alessandro/W-8635-2019
OI Andreotti, Felicita/0000-0002-1456-6430
CR Andreotti F, 1999, Cardiologia, V44, P997
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NR 39
TC 54
Z9 56
U1 1
U2 2
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0195-668X
EI 1522-9645
J9 EUR HEART J
JI Eur. Heart J.
PD OCT
PY 2001
VL 22
IS 20
BP 1924
EP 1930
DI 10.1053/euhj.2001.2624
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 488RE
UT WOS:000171948800007
PM 11601836
DA 2025-06-11
ER

PT J
AU Zuo, JS
   Ren, JY
   Yin, BW
   Wang, ZY
   Cui, QQ
   Liu, JR
   Huang, D
   Pei, HT
   Wen, R
   Zhang, YD
   Ma, YX
AF Zuo, Jinshi
   Ren, Jingyi
   Yin, Bowen
   Wang, Ziyi
   Cui, Qiqi
   Liu, Jiarui
   Huang, Dan
   Pei, Huanting
   Wen, Rui
   Zhang, Yadong
   Ma, Yuxia
TI Effects of Sesamin in Animal Models of Obesity-Associated Diseases: A
   Systematic Review and Meta-Analysis
SO NUTRITION REVIEWS
LA English
DT Review
DE sesamin; meta-analysis; obesity; non-alcoholic fatty liver disease; type
   2 diabetes; metabolic syndrome
ID HIGH-FAT DIET; METABOLIC SYNDROME; INSULIN-RESISTANCE; OXIDATIVE STRESS;
   HEALTH; INFLAMMATION; LIGNAN; RISK; RATS; DYSFUNCTION
AB Context As living standards have improved and lifestyles have undergone changes, metabolic diseases associated with obesity have become increasingly prevalent. It is well established that sesamin (Ses) (PubChem CID: 72307), the primary lignans in sesame seeds and sesame oil, possess antioxidant and anti-inflammatory effects. Objective In this study, a systematic review and meta-analysis of the effects of Ses on animal models of obesity-related diseases was performed to assess their impact on relevant disease parameters. Importantly, this study sought to provide insights for the design of future human clinical studies utilizing Ses as a nutritional supplement or drug. Data Sources This study conducted a comprehensive search in PubMed, Web of Science, Embase, Scopus, and the Cochrane Library, identifying English language articles published from inception to April 2023. Data Extraction The search incorporated keywords such as "sesamin," "obesity," "non-alcoholic fatty liver disease," "type 2 diabetes mellitus," and "metabolic syndrome." The meta-analysis included 17 articles on non-alcoholic fatty liver disease, type 2 diabetes, and metabolic syndrome. Data Analysis Overall, the pooled results demonstrated that Ses significantly reduced levels of total serum cholesterol (P = .010), total serum triglycerides (P = .003), alanine transaminase (P = .003), and blood glucose (P < .001), and increased high-density lipoprotein cholesterol levels (P = .012) in animal models of nonalcoholic fatty liver disease. In the type 2 diabetes model, Ses mitigated drug-induced weight loss (P < .001), high-fat-diet-induced weight gain (P < .001), and blood glucose levels (P = .001). In the metabolic syndrome model, Ses was associated with a significant reduction in body weight (P < .001), total serum cholesterol (P < .001), total serum triglycerides (P < .001), blood glucose (P < .001), and alanine transaminase levels (P = .039). Conclusion The meta-analysis results of this study suggest that Ses supplementation yields favorable effects in animal models of obesity-related diseases, including hypolipidemic, insulin-lowering, and hypoglycemic abilities, as well as organ protection from oxidative stress and reduced inflammation.
C1 [Zuo, Jinshi; Ren, Jingyi; Yin, Bowen; Pei, Huanting; Wen, Rui; Zhang, Yadong; Ma, Yuxia] Hebei Med Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Hebei Key Lab Environm & Human Hlth, Zhongshan East Rd, Shijiazhuang 050017, Peoples R China.
   [Wang, Ziyi; Huang, Dan] Hebei Med Univ, Undergraduate Coll Publ Hlth, Shijiazhuang 050017, Peoples R China.
   [Cui, Qiqi; Liu, Jiarui] Hebei Med Univ, Undergraduate Coll Basic Med, Shijiazhuang 050017, Peoples R China.
C3 Hebei Medical University; Hebei Medical University; Hebei Medical
   University
RP Ma, YX (corresponding author), Hebei Med Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Hebei Key Lab Environm & Human Hlth, Zhongshan East Rd, Shijiazhuang 050017, Peoples R China.
EM mayuxia@hebmu.edu.cn
RI Yin, Bowen/KZV-0738-2024
FU National Natural Science Foundation of China; Home for Researchers
   editorial team
FX We thank the Home for Researchers editorial team
   (www.home-for-researchers.com) for language editing services.
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NR 54
TC 2
Z9 2
U1 4
U2 8
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0029-6643
EI 1753-4887
J9 NUTR REV
JI Nutr. Rev.
PD JUL 29
PY 2024
VL 83
IS 3
DI 10.1093/nutrit/nuae089
EA JUL 2024
PG 15
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA W4W8U
UT WOS:001280089100001
PM 39074164
DA 2025-06-11
ER

PT J
AU Mathews, MJ
   Mathews, EH
   Liebenberg, L
AF Mathews, Marc J.
   Mathews, Edward H.
   Liebenberg, Leon
TI The mechanisms by which antidepressants may reduce coronary heart
   disease risk
SO BMC CARDIOVASCULAR DISORDERS
LA English
DT Article
ID MAJOR DEPRESSIVE DISORDER; SEROTONIN REUPTAKE INHIBITORS; NEUROTROPHIC
   FACTOR BDNF; C-REACTIVE PROTEIN; CARDIOVASCULAR-DISEASE;
   PHYSICAL-ACTIVITY; TRICYCLIC ANTIDEPRESSANTS; MYOCARDIAL-INFARCTION;
   METABOLIC SYNDROME; CHOLESTEROL LEVELS
AB Background: Depression is known to increase the risk for coronary heart disease (CHD) likely through various pathogenetic actions. Understanding the links between depression and CHD and the effects of mediating these links may prove beneficial in CHD prevention.
   Methods: An integrated model of CHD was used to elucidate pathogenetic pathways of importance between depression and CHD. Using biomarker relative risk data the pathogenetic effects are representable as measurable effects based on changes in biomarkers.
   Results: A 'connection graph' presents interactions by illustrating the relationship between depression and the biomarkers of CHD. The use of selective serotonin reuptake inhibitors (SSRIs) is postulated to have potential to decrease CHD risk. Comparing the 'connection graph' of SSRI's to that of depression elucidates the possible actions through which risk reduction may occur.
   Conclusions: The CHD effects of depression appear to be driven by increased inflammation and altered metabolism. These effects might be mediated with the use of SSRI's.
C1 [Mathews, Marc J.; Mathews, Edward H.; Liebenberg, Leon] North West Univ, CRCED Pretoria, POB 11207, ZA-0054 Silver Lakes, South Africa.
C3 North West University - South Africa
RP Mathews, MJ (corresponding author), North West Univ, CRCED Pretoria, POB 11207, ZA-0054 Silver Lakes, South Africa.
EM mjmathews@rems2.com
RI LIEBENBERG, LEON/B-6738-2009; Liebenberg, Leon/A-4083-2015
OI Mathews, Marc/0000-0003-4439-8797; Liebenberg, Leon/0000-0002-0834-6212
CR [Anonymous], CARDIOVASCULAR RISK
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NR 127
TC 10
Z9 10
U1 0
U2 15
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1471-2261
J9 BMC CARDIOVASC DISOR
JI BMC Cardiovasc. Disord.
PD AUG 1
PY 2015
VL 15
AR 82
DI 10.1186/s12872-015-0074-5
PG 12
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA CN9HV
UT WOS:000358758800001
PM 26231223
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Wong, SK
   Chin, KY
   Ahmad, F
   Ima-Nirwana, S
AF Wong, Sok Kuan
   Chin, Kok-Yong
   Ahmad, Fairus
   Ima-Nirwana, Soelaiman
TI Regulation of inflammatory response and oxidative stress by tocotrienol
   in a rat model of non-alcoholic fatty liver disease
SO JOURNAL OF FUNCTIONAL FOODS
LA English
DT Article
DE Anti-inflammation; Antioxidants; Metabolic syndrome; Tocopherol; Vitamin
   E
ID VITAMIN-E; INDUCED NEPHROPATHY; METABOLIC SYNDROME; GAMMA-TOCOTRIENOL;
   BONE; LESSONS; OBESITY; DIET
AB This study investigated the effects of tocotrienol on inflammation, oxidative stress and non-alcoholic fatty liver disease (NAFLD). Male rats were fed with high-carbohydrate high-fat (HCHF) diet and treated with either 60 or 100 mg/kg annatto tocotrienol or palm tocotrienol. Activated Toll-like receptor (TLR) and its downstream targets, increased lipid peroxidation, decreased antioxidant levels in liver and higher serum C-reactive protein (CRP) level were detected in the HCHF rats. Higher steatosis, lobular inflammation, hepatocyte ballooning, NAFLD activity score and lipid deposition was noted. Tocotrienol inhibited TLR activation, increased interleukin-10, reduced lipid peroxidation and raised antioxidant activities in the liver. Lower serum CRP level was observed after tocotrienol administration. Palm tocotrienol (100 mg/kg) reduced steatosis grade in the HCHF rats. In conclusion, tocotrienol potentially mitigates inflammatory response, oxidative stress and steatosis in this animal model of NAFLD. The alleviation of inflammation may be in part mediated through the suppression of TLR activation.
C1 [Wong, Sok Kuan; Chin, Kok-Yong; Ima-Nirwana, Soelaiman] Univ Kebangsaan Malaysia, Fac Med, Dept Pharmacol, Jalan Yaacob Latif, Kuala Lumpur 56000, Malaysia.
   [Ahmad, Fairus] Univ Kebangsaan Malaysia, Fac Med, Dept Anat, Jalan Yaacob Latif, Kuala Lumpur 56000, Malaysia.
C3 Universiti Kebangsaan Malaysia; Universiti Kebangsaan Malaysia
RP Ima-Nirwana, S (corresponding author), Univ Kebangsaan Malaysia, Fac Med, Dept Pharmacol, Jalan Yaacob Latif, Kuala Lumpur 56000, Malaysia.
EM imasoel@ppukm.ukm.edu.my
RI Soelaiman, Ima/C-4289-2017; Chin, Kok-Yong/B-6309-2015; Wong, Sok
   Kuan/I-1243-2016
OI Chin, Kok-Yong/0000-0001-6628-1552; Wong, Sok Kuan/0000-0003-1184-4551;
   Ahmad, Fairus/0000-0002-2452-6459
FU Universiti Kebangsaan Malaysia [FF-2020-366]; Malaysia Toray Science
   Foundation [FF-2019-036]
FX This work was supported by Universiti Kebangsaan Malaysia [Grant number:
   FF-2020-366] and Malaysia Toray Science Foundation [Grant number:
   FF-2019-036].
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NR 65
TC 12
Z9 12
U1 0
U2 9
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1756-4646
EI 2214-9414
J9 J FUNCT FOODS
JI J. Funct. Food.
PD NOV
PY 2020
VL 74
AR 104209
DI 10.1016/j.jff.2020.104209
PG 10
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA NZ2SF
UT WOS:000576945800003
OA gold
DA 2025-06-11
ER

PT J
AU Ataie, Z
   Mehrani, H
   Ghasemi, A
   Farrokhfall, K
AF Ataie, Zomorrod
   Mehrani, Hossein
   Ghasemi, Asghar
   Farrokhfall, Khadijeh
TI Cinnamaldehyde has beneficial effects against oxidative stress and
   nitric oxide metabolites in the brain of aged rats fed with long-term,
   high-fat diet
SO JOURNAL OF FUNCTIONAL FOODS
LA English
DT Article
DE Cinnamaldehyde; Oxidative stress; Nitric oxide; Brain; High fat diet;
   Rat
ID COGNITIVE IMPAIRMENT; LEPTIN; EXTRACT; MICE; ANTIOXIDANT; DYSFUNCTION;
   NUTRITION; CINNAMON; DISEASE
AB Introduction In this study, a novel use of Cinnamaldehyde in protection of brain oxidative stress was explored.
   Methods: Male Wistar rats were placed on either a high fat diet (HFD) or a normal diet, starting at 12 weeks of age and lasted for 16 weeks to establish metabolic syndrome. Then, Cinnamaldehyde (20 mg/kg) was daily given orally for 24 weeks. Malondialdehyde and nitric oxide metabolites (NOx) were evaluated in cerebellum, hippocampus, and cortex.
   Results: The HFD increased malondialdehyde in serum and the brain. Although, NOx concentration was increased in cerebellum, it decreased in serum and adrenal. Cinnamaldehyde lowered lipid peroxidation in serum and brain of HFD rats. Moreover, it restored NOx alterations in adrenal and cerebellum.
   Conclusion: The results of the present study provide evidence supporting beneficial effects of Cinnamaldehyde on brain disorders associated with metabolic syndrome and aging.
C1 [Ataie, Zomorrod] Birjand Univ Med Sci, Fac Med, Med Toxicol & Drug Abuse Res Ctr MTDRC, Birjand, Iran.
   [Ataie, Zomorrod] Islamic Azad Univ, Zahedan Branch, Fac Med, Zahedan, Iran.
   [Mehrani, Hossein] Islamic Azad Univ, Neyshabur Branch, Fac Sci & Med, Dept Biochem, Neyshabur, Iran.
   [Ghasemi, Asghar] Shahid Beheshti Univ Med Sci, Res Inst Endocrine Sci, Endocrine Physiol Res Ctr, Tehran, Iran.
   [Farrokhfall, Khadijeh] Birjand Univ Med Sci, Fac Med, Cardiovasc Res Ctr, Birjand, Iran.
C3 Birjand University of Medical Sciences; Islamic Azad University; Islamic
   Azad University; Shahid Beheshti University Medical Sciences; Birjand
   University of Medical Sciences
RP Farrokhfall, K (corresponding author), Birjand Univ Med Sci, Fac Med, Cardiovasc Res Ctr, Birjand, Iran.
EM k.farrokhfall@bums.ac.ir
RI Ghasemi, Asghar/O-4145-2017
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NR 50
TC 27
Z9 29
U1 0
U2 12
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1756-4646
J9 J FUNCT FOODS
JI J. Funct. Food.
PD JAN
PY 2019
VL 52
BP 545
EP 551
DI 10.1016/j.jff.2018.11.038
PG 7
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA HH4KR
UT WOS:000455691800058
DA 2025-06-11
ER

PT J
AU Silva, DA
   Coutinho, EDF
   Ferriani, LO
   Viana, MC
AF Silva, Daniela Alves
   Freire Coutinho, Evandro da Silva
   Ferriani, Lara Onofre
   Viana, Maria Carmen
TI Depression subtypes and obesity in adults: A systematic review and
   meta-analysis
SO OBESITY REVIEWS
LA English
DT Review
DE atypical depression; body mass index; melancholic depression;
   meta-analysis
ID BODY-MASS INDEX; MAJOR DEPRESSION; ATYPICAL DEPRESSION; METABOLIC
   SYNDROME; WEIGHT-GAIN; SYMPTOMS; DISORDER; ASSOCIATIONS; FEATURES; FAT
AB Examining clinical features of depressive episodes may help elucidating the nature of association between depression and obesity, related to specific symptoms such as appetite and weight changes. This meta-analysis of observational studies evaluated whether subtypes of depression are associated with specific anthropometric profiles in adults. We searched MEDLINE, LILACS, PsycINFO, Scopus, Web of Science databases, and Grey Literature for articles published up to October 2016 that examined depressive subtypes and adiposity measures among adults. The pooled effect size was estimated with random effects models. The PRISMA guidelines were adopted to reporting results, and this review was registered in PROSPERO (CRD42016035685). A total of 22 articles were included in this systematic review, of which eight had data included in the meta-analysis, assessing 14 757 individuals with depression. Patients with atypical depression presented a 2.55 higher BMI score compared with those with melancholic depression. Subgroup analysis identified a differential distribution of anthropometric measures in studies conducted with Chinese populations. Among the remainder studies, only one reported discrepant results, possibly due to the exclusion of "weight change" in defining subtypes of depression. Atypical depression was significantly associated with elevated BMI compared with melancholic depression, deserving particular attention due to its clinical importance.
C1 [Silva, Daniela Alves; Ferriani, Lara Onofre; Viana, Maria Carmen] Univ Fed Espirito Santo, Postgrad Program Publ Hlth, Vitoria, ES, Brazil.
   [Silva, Daniela Alves] Univ Fed Espirito Santo, Dept Hlth Integrated Educ, Vitoria, ES, Brazil.
   [Freire Coutinho, Evandro da Silva] Natl Sch Publ Hlth, Dept Epidemiol, Rio De Janeiro, Brazil.
   [Viana, Maria Carmen] Univ Fed Espirito Santo, Dept Social Med, Vitoria, ES, Brazil.
C3 Universidade Federal do Espirito Santo; Universidade Federal do Espirito
   Santo; Universidade Federal do Espirito Santo
RP Silva, DA (corresponding author), Univ Fed Espirito Santo, Postgrad Program Publ Hlth, Vitoria, ES, Brazil.
EM contato.daniela.nut@gmail.com
RI Coutinho, Evandro/E-2408-2011
OI Silva, Daniela Alves/0000-0001-7396-2305; Coutinho,
   Evandro/0000-0002-4649-7353; Onofre Ferriani, Lara/0000-0002-6095-8590
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NR 56
TC 66
Z9 68
U1 0
U2 33
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1467-7881
EI 1467-789X
J9 OBES REV
JI Obes. Rev.
PD MAR
PY 2020
VL 21
IS 3
DI 10.1111/obr.12966
EA NOV 2019
PG 13
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism
GA KI6FU
UT WOS:000496160100001
PM 31724325
DA 2025-06-11
ER

PT J
AU Huang, YX
   Yan, YX
   Xv, WC
   Qian, G
   Li, CJ
   Zou, HQ
   Li, YQ
AF Huang, Yuxiang
   Yan, Yuxiang
   Xv, Weicheng
   Qian, Ge
   Li, Chijian
   Zou, Hequn
   Li, Yongqiang
TI A New Insight into the Roles of MiRNAs in Metabolic Syndrome
SO BIOMED RESEARCH INTERNATIONAL
LA English
DT Review
ID GESTATIONAL DIABETES-MELLITUS; INDUCED INSULIN-RESISTANCE; OXIDATIVE
   STRESS; ADIPOSE-TISSUE; LIPID-METABOLISM; URIC-ACID; BLOOD-PRESSURE;
   MECHANISTIC INSIGHTS; CIRCULATING MIRNAS; DOWN-REGULATION
AB Metabolic syndrome (MetS), which includes several clinical components such as abdominal obesity, insulin resistance (IR), dyslipidemia, microalbuminuria, hypertension, proinflammatory state, and oxidative stress (OS), has become a global epidemic health issue contributing to a high risk of type 2 diabetes mellitus (T2DM). In recent years, microRNAs (miRNAs), used as noninvasive biomarkers for diagnosis and therapy, have aroused global interest in complex processes in health and diseases, including MetS and its components. MiRNAs can exist stably in serum, liver, skeletal muscle (SM), heart muscle, adipose tissue (AT), and cells, because of their ability to escape the digestion of RNase. Here we first present an overall review on recent findings of the relationship between miRNAs and several main components of MetS, such as IR, obesity, diabetes, lipid metabolism, hypertension, hyperuricemia, and stress, to illustrate the targeting proteins or relevant pathways that are involved in the progress of MetS and also help us find promising novel diagnostic and therapeutic strategies.
C1 [Huang, Yuxiang; Xv, Weicheng; Qian, Ge; Li, Chijian; Zou, Hequn; Li, Yongqiang] Southern Med Univ, Affiliated Hosp 3, Inst Nephrol & Urol, Dept Nephrol, Guangzhou, Guangdong, Peoples R China.
   [Yan, Yuxiang] Capital Med Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing, Peoples R China.
C3 Southern Medical University - China; Capital Medical University
RP Li, YQ (corresponding author), Southern Med Univ, Affiliated Hosp 3, Inst Nephrol & Urol, Dept Nephrol, Guangzhou, Guangdong, Peoples R China.
EM liyongqiang851@163.com
RI Zou, He/GXH-0280-2022
OI Li, Yongqiang/0000-0002-7572-2353
FU Guangdong Provincial Science and Technology Project [2014A020212662];
   Science and Technology Planning Project of Southern Medical University
   [CX2016N018]; Science and Technology Planning Project of Tianhe
   District, Guangzhou City [201704KW011]; Natural Science Foundation of
   Guangdong Province [2016A030313559]; South Wisdom Valley Innovative
   Research Team Program [CXTD-004]; Science and Technique Program of
   Guangzhou [201604020015]
FX This work was supported by the Guangdong Provincial Science and
   Technology Project (No. 2014A020212662), the Science and Technology
   Planning Project of Southern Medical University (No. CX2016N018), the
   Science and Technology Planning Project of Tianhe District, Guangzhou
   City (No. 201704KW011), the Natural Science Foundation of Guangdong
   Province (No. 2016A030313559), and the South Wisdom Valley Innovative
   Research Team Program (No. CXTD-004, 2014), the Science and Technique
   Program of Guangzhou (No. 201604020015).
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NR 133
TC 36
Z9 37
U1 0
U2 10
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2314-6133
EI 2314-6141
J9 BIOMED RES INT
JI Biomed Res. Int.
PY 2018
VL 2018
AR 7372636
DI 10.1155/2018/7372636
PG 15
WC Biotechnology & Applied Microbiology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Research & Experimental Medicine
GA HG2IZ
UT WOS:000454788000001
PM 30648107
OA hybrid, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Schmitt, B
   Vicenzi, M
   Garrel, C
   Denis, FM
AF Schmitt, Bernard
   Vicenzi, Morgane
   Garrel, Catherine
   Denis, Frederic M.
TI Effects of N-acetylcysteine, oral glutathione (GSH) and a novel
   sublingual form of GSH on oxidative stress markers: A comparative
   crossover study.
SO REDOX BIOLOGY
LA English
DT Article
DE Glutathione; Oral bioavailability; N-acetyl cysteine; Oxidative stress;
   Metabolic syndrome; Dietary supplement; Nutraceuticals; Sublingual
ID VITAMIN-C; PLASMA; ANTIOXIDANT; SUPPLEMENTATION; SURVIVAL; DECLINE; AGE
AB Glutathione (GSH) is critical to fight against oxidative stress. Its very low bioavailability limits the interest of a supplementation. The purpose of this study was to compare the bioavailability, the effect on oxidative stress markers and the safety of a new sublingual form of GSH with two commonly used dietary supplements, N-acetylcysteine (NAC) and oral GSH. The study was a three-week randomized crossover trial. 20 Volunteers with metabolic syndrome were enrolled. GSH levels and several oxidative stress markers were determined at different times during each 21-clays period. Compared to oral GSH group, an increase of total and reduced GSH levels in plasma and a higher GSH/GSSG ratio (p=0.003) was observed in sublingual GSH group. After 3 weeks of administration, there was a significant increase of vitamin E level in plasma only in sublingual GSH group (0.83 mu mol/g; p=.004). Our results demonstrate the superiority of a new sublingual form of GSH over the oral GSH form and NAC in terms of GSH supplementation. (C) 2015 The Authors. Published by Elsevier B.V.
C1 [Schmitt, Bernard] Ctr Hosp Bretagne Sud, Ctr Enseignement & Rech Nutr Humaine, F-56322 Lorient, France.
   [Vicenzi, Morgane; Denis, Frederic M.] Labs Le Stum, F-56260 Larmor Plage, France.
   [Garrel, Catherine] CHU Grenoble, Inst Biol & Pathol, Dept Biochim Toxicol & Pharmacol, Unite Biochim Hormonale & Nutr, F-38043 Grenoble, France.
C3 Communaute Universite Grenoble Alpes; Universite Grenoble Alpes (UGA);
   CHU Grenoble Alpes
RP Denis, FM (corresponding author), Labs Le Stum, 4 Impasse Kerhoas, F-56260 Larmor Plage, France.
EM schmitt.lorient@yahoo.fr; innov@labo-lestum.com;
   CGarrel@chu-grenoble.fr; infomed@labo-lestum.com
FU Laboratoires Le Stum
FX The study was sponsored by Laboratoires Le Stum. The authors thank
   Cheryl Myers for her careful reading of our manuscript.
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NR 35
TC 143
Z9 155
U1 2
U2 37
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2213-2317
J9 REDOX BIOL
JI Redox Biol.
PD DEC
PY 2015
VL 6
BP 198
EP 205
DI 10.1016/j.redox.2015.07.012
PG 8
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA CZ8GR
UT WOS:000367338700019
PM 26262996
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Street, ME
   Casadei, F
   Di Bari, ER
   Ferraboschi, F
   Montani, AG
   Shulhai, AM
   Esposito, S
AF Street, Maria Elisabeth
   Casadei, Federica
   Di Bari, Erika Rita
   Ferraboschi, Francesca
   Montani, Anna Giuseppina
   Shulhai, Anna-Mariia
   Esposito, Susanna
TI The Role of Nutraceuticals and Probiotics in Addition to Lifestyle
   Intervention in the Management of Childhood Obesity-Part 1: Metabolic
   Changes
SO NUTRIENTS
LA English
DT Review
DE obesity; nutraceuticals; probiotics; metabolic syndrome; dyslipidemia;
   insulin resistance; diabetes mellitus
ID FATTY LIVER-DISEASE; OLIGOFRUCTOSE PROMOTES SATIETY; CARDIOMETABOLIC
   RISK-FACTORS; VITAMIN-D SUPPLEMENTATION; ALPHA-LIPOIC ACID; INSULIN
   SENSITIVITY; DOUBLE-BLIND; MULBERRY LEAF; DOCOSAHEXAENOIC ACID;
   OXIDATIVE STRESS
AB Childhood obesity is a growing global health issue. Its rising prevalence is linked to genetic, environmental, and lifestyle factors. Obesity in children could lead to different comorbidities and complications with an increased risk of metabolic disorders, such as insulin resistance, dyslipidemia, type 2 diabetes mellitus (T2DM), and metabolic dysfunction-associated steatotic liver disease (MASLD). First-line treatment involves dietary modifications and lifestyle changes; however, adherence is often poor and remains a significant challenge. Pharmacotherapy, while a potential option, has limitations in availability and can cause side effects, leading to growing interest in alternative treatments, such as nutraceutical compounds. Derived from natural sources, these compounds have different anti-inflammatory, antiallergic, antioxidant, antibacterial, antifungal, neuroprotective, antiaging, antitumor, insulin-sensitizing, glucose, and lipid-lowering effects. This review describes commonly used nutraceutical compounds, such as omega-3 fatty acids, vitamin D, polyphenols (such as resveratrol and curcumin), berberine, white mulberry leaves and others, and pre- and probiotics in the management of obesity, evaluating the evidence on their mechanisms of action and efficacy in metabolic comorbidities. The evidence suggests that the integration of nutraceuticals into the diet may positively influence body mass index, glucose metabolism, lipid profiles, and gut microbiota composition and reduce inflammation in obese individuals. These effects may provide future practical guidance for clinical practice, contribute to metabolic health improvement, and potentially prevent obesity-related complications. In this first part, we discuss the effects of nutraceutical compounds on insulin sensitivity and insulin resistance, T2DM, dyslipidemia, and MASLD in addition to diet and lifestyle interventions.
C1 [Street, Maria Elisabeth; Casadei, Federica; Di Bari, Erika Rita; Ferraboschi, Francesca; Montani, Anna Giuseppina; Shulhai, Anna-Mariia; Esposito, Susanna] Univ Parma, Dept Med & Surg, I-43126 Parma, Italy.
   [Street, Maria Elisabeth; Esposito, Susanna] Univ Hosp Parma, P Barilla Childrens Hosp, Unit Paediat, I-43126 Parma, Italy.
C3 University of Parma; University of Parma; University Hospital of Parma
RP Street, ME (corresponding author), Univ Parma, Dept Med & Surg, I-43126 Parma, Italy.; Street, ME (corresponding author), Univ Hosp Parma, P Barilla Childrens Hosp, Unit Paediat, I-43126 Parma, Italy.
EM mariaelisabeth.street@unipr.it; federica.casadei@unipr.it;
   erikarita.dibari@unipr.it; francesca.ferraboschi@unipr.it;
   annagiuseppina.montani@unipr.it; annashulhai@gmail.com;
   susannamariaroberta.esposito@unipr.it
RI Shulhai, Anna-Mariia/HJY-8878-2023; Street, Maria/B-7099-2011
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NR 183
TC 0
Z9 0
U1 0
U2 0
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD MAY 9
PY 2025
VL 17
IS 10
AR 1630
DI 10.3390/nu17101630
PG 31
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 3AJ7R
UT WOS:001495627900001
PM 40431370
DA 2025-06-11
ER

PT J
AU Christensen, RH
   von Scholten, BJ
   Lehrskov, LL
   Rossing, P
   Jorgensen, PG
AF Christensen, Regitse Hojgaard
   von Scholten, Bernt Johan
   Lehrskov, Louise Lang
   Rossing, Peter
   Jorgensen, Peter Godsk
TI Epicardial adipose tissue: an emerging biomarker of cardiovascular
   complications in type 2 diabetes?
SO THERAPEUTIC ADVANCES IN ENDOCRINOLOGY AND METABOLISM
LA English
DT Review
DE epicardial adipose tissue; type 2 diabetes; cardiovascular disease;
   cardiac adipose tissue; pericardial adipose tissue
ID CORONARY-ARTERY-DISEASE; MYOCARDIAL TRIGLYCERIDE CONTENT; IMPAIRED
   FASTING GLUCOSE; VISCERAL ABDOMINAL FAT; PERICARDIAL FAT; RISK-FACTORS;
   HEART-FAILURE; DIASTOLIC FUNCTIONS; INSULIN-RESISTANCE; METABOLIC
   SYNDROME
AB Type 2 diabetes (T2D) is associated with an increased risk of cardiovascular disease and heart failure, which highlights the need for improved understanding of factors contributing to the pathophysiology of these complications as they are the leading cause of mortality in T2D. Patients with T2D have high levels of epicardial adipose tissue (EAT). EAT is known to secrete inflammatory factors, lipid metabolites, and has been proposed to apply mechanical stress on the cardiac muscle that may accelerate atherosclerosis, cardiac remodeling, and heart failure. High levels of EAT in patients with T2D have been associated with atherosclerosis, diastolic dysfunction, and incident cardiovascular events, and this fat depot has been suggested as an important link coupling diabetes, obesity, and cardiovascular disease. Despite this, the predictive potential of EAT in general, and in patients with diabetes, is yet to be established, and, up until now, the clinical relevance of EAT is therefore limited. Should this link be established, importantly, studies show that this fat depot can be modified both by pharmacological and lifestyle interventions. In this review, we first introduce the role of adipose tissue in T2D and present mechanisms involved in the pathophysiology of EAT and pericardial adipose tissue (PAT) in general, and in patients with T2D. Next, we summarize the evidence that these fat depots are elevated in patients with T2D, and discuss whether they might drive the high cardiometabolic risk in patients with T2D. Finally, we discuss the clinical potential of cardiac adipose tissues, address means to target this depot, and briefly touch upon underlying mechanisms and future research questions.
C1 [Christensen, Regitse Hojgaard] Rigshosp, Dept 7641, Ctr Phys Act Res, Ctr Inflammat & Metab, Blegdamsvej 9, DK-2100 Copenhagen O, Denmark.
   [Christensen, Regitse Hojgaard; von Scholten, Bernt Johan; Rossing, Peter] Steno Diabet Ctr Copenhagen, Gentofte, Denmark.
   [Lehrskov, Louise Lang] Rigshosp, Ctr Phys Act Res, Ctr Inflammat & Metab, Copenhagen, Denmark.
   [Rossing, Peter] Univ Copenhagen, Fac Hlth & Med Sci, Dept Clin Med, Copenhagen, Denmark.
   [Jorgensen, Peter Godsk] Herlev Gentofte Hosp, Dept Cardiol, Hellerup, Denmark.
C3 Rigshospitalet; Steno Diabetes Center; University of Copenhagen;
   Copenhagen University Hospital; Rigshospitalet; University of Copenhagen
RP Christensen, RH (corresponding author), Rigshosp, Dept 7641, Ctr Phys Act Res, Ctr Inflammat & Metab, Blegdamsvej 9, DK-2100 Copenhagen O, Denmark.; Christensen, RH (corresponding author), Steno Diabet Ctr Copenhagen, Gentofte, Denmark.
EM regitseh@gmail.com
RI rossing, peter/AAH-7879-2021
OI von Scholten, Bernt Johan/0000-0002-1489-0636; Lang Lehrskov,
   Louise/0000-0002-1947-4252; Jorgensen, Peter/0000-0002-1217-8944;
   christensen, regitse/0000-0001-5316-5341; rossing,
   peter/0000-0002-1531-4294
FU AbbVie; AstraZeneca; Novo Nordisk
FX Research grants from AbbVie, AstraZeneca and Novo Nordisk. BJvS is now
   employed at Novo Nordisk and has equity interest in Novo Nordisk. PGJ
   reports having received lecture fees from Novo Nordisk.
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NR 153
TC 42
Z9 44
U1 0
U2 7
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 2042-0188
EI 2042-0196
J9 THER ADV ENDOCRINOL
JI Ther. Adv. Endocrinol. Metab.
PD MAY
PY 2020
VL 11
AR 2042018820928824
DI 10.1177/2042018820928824
PG 16
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA LU6IN
UT WOS:000537857100001
PM 32518616
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Svigkou, A
   Katsi, V
   Kordalis, VG
   Tsioufis, K
AF Svigkou, Asimenia
   Katsi, Vasiliki
   Kordalis, Vasilios G.
   Tsioufis, Konstantinos
TI The Molecular Basis of the Augmented Cardiovascular Risk in Offspring of
   Mothers with Hypertensive Disorders of Pregnancy
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE preeclampsia; atherosclerosis; endothelial dysfunction; cardiometabolic
   risk factors
ID INCREASED BLOOD-PRESSURE; ANGIOTENSIN-II; OXIDATIVE STRESS; VASCULAR
   DYSFUNCTION; DEVELOPMENTAL ORIGINS; PLACENTAL ISCHEMIA; GENE-EXPRESSION;
   NONCODING RNAS; BIRTH-WEIGHT; PREECLAMPSIA
AB The review examines the impact of maternal preeclampsia (PE) on the cardiometabolic and cardiovascular health of offspring. PE, a hypertensive disorder of pregnancy, is responsible for 2 to 8% of pregnancy-related complications. It significantly contributes to adverse outcomes for their infants, affecting the time of birth, the birth weight, and cardiometabolic risk factors such as blood pressure, body mass index (BMI), abdominal obesity, lipid profiles, glucose, and insulin. Exposure to PE in utero predisposes offspring to an increased risk of cardiometabolic diseases (CMD) and cardiovascular diseases (CVD) through mechanisms that are not fully understood. The incidence of CMD and CVD is constantly increasing, whereas CVD is the main cause of morbidity and mortality globally. A complex interplay of genes, environment, and developmental programming is a plausible explanation for the development of endothelial dysfunction, which leads to atherosclerosis and CVD. The underlying molecular mechanisms are angiogenic imbalance, inflammation, alterations in the renin-angiotensin-aldosterone system (RAAS), endothelium-derived components, serotonin dysregulation, oxidative stress, and activation of both the hypothalamic-pituitary-adrenal axis and hypothalamic-pituitary-gonadal axis. Moreover, the potential role of epigenetic factors, such as DNA methylation and microRNAs as mediators of these effects is emphasized, suggesting avenues for future research and therapeutic interventions.
C1 [Svigkou, Asimenia; Katsi, Vasiliki; Tsioufis, Konstantinos] Natl & Kapodistrian Univ Athens, Hippokrat Gen Hosp, Sch Med, Cardiol Dept, Athens 15772, Greece.
   [Kordalis, Vasilios G.] Aristotle Univ Thessaloniki, Sch Med, Thessaloniki 54124, Greece.
C3 Athens Medical School; National & Kapodistrian University of Athens;
   Aristotle University of Thessaloniki
RP Katsi, V (corresponding author), Natl & Kapodistrian Univ Athens, Hippokrat Gen Hosp, Sch Med, Cardiol Dept, Athens 15772, Greece.
EM asimeniasvigkou@gmail.com; vkkatsi@yahoo.gr; kordalisvg@gmail.com;
   kptsioufis@gmail.com
OI , Asimenia Svigkou/0009-0004-0953-9544
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NR 171
TC 1
Z9 1
U1 4
U2 5
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD MAY
PY 2024
VL 25
IS 10
AR 5455
DI 10.3390/ijms25105455
PG 22
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA SD8I6
UT WOS:001232608000001
PM 38791492
OA gold
DA 2025-06-11
ER

PT J
AU Saeed, AAM
   Noreen, S
   Awlqadr, FH
   Farooq, MI
   Qadeer, M
   Rai, N
   Farag, HA
   Saeed, MN
AF Muhammed Saeed, Aya A.
   Noreen, Sobia
   Awlqadr, Farhang H.
   Farooq, Muhammad Irshad
   Qadeer, Maria
   Rai, Nadia
   Farag, Halgurd Ali
   Saeed, Mohammed N.
TI Nutritional and herbal interventions for polycystic ovary syndrome
   (PCOS): a comprehensive review of dietary approaches, macronutrient
   impact, and herbal medicine in management
SO JOURNAL OF HEALTH POPULATION AND NUTRITION
LA English
DT Review
DE Nutrition; Macronutrients and micronutrients; Metabolic syndrome;
   Insulin resistance; Reproductive health; Endocrine disorders
ID CARDIOMETABOLIC RISK-FACTORS; INSULIN-RESISTANCE; OXIDATIVE STRESS;
   OBESE WOMEN; LIPID PROFILES; DOUBLE-BLIND; WEIGHT-LOSS; CARBOHYDRATE
   DIET; METABOLIC FACTORS; HYPOCALORIC DIET
AB Polycystic Ovary Syndrome (PCOS) is a common health condition related to a woman's hormonal problems. Hormonal imbalance, metabolic disorders, and an increased insulin level mainly characterize the ailment. This detailed review focuses on dietary strategies, macromolecules, macromolecules, and herbal interventions that exception-ally work in PCOS treatment. Research has shown that Mediterranean, low-glycemic index, and ketogenic diets that are modified with individuals in mind are the best ways to resolve insulin resistance, obesity, and lack of ovulation. The other nutrients shown to affect glucose metabolism and play a role in hormone regulation are the macromolecules, such as increased protein and reduced refined carbs. Among the different micronutrients, vitamin D, omega-3 fatty acids, and inositol were shown to be the most vital supplements in the treatment of PCOS-induced oxidative damage, hyperandrogenism, and infertility. Not to mention, cinnamon, curcumin, sage, fennel, and traditional Chinese herbal medicine are among some of the herbal remedies that so far show good potential to be the perfect complementary therapy tools as they create better glycemic control, inflammation reduction, and menstrual cycle regularization. Even though the findings are promising, the current supply of clinical trials for standardizing these nutritional and herbal protocols is lacking. Overall, this report stresses the fact that a customized, holistic diet regime is the best treatment for women with PCOS to make them feel well and live a long and healthy life.
C1 [Muhammed Saeed, Aya A.; Awlqadr, Farhang H.; Farag, Halgurd Ali] Sulaimani Polytech Univ, Halabja Tech Coll, Dept Food Sci & Qual Control, Sulaymaniyah, Iraq.
   [Noreen, Sobia] Univ Innsbruck, Inst Pharm, Dept Pharmaceut Technol, Innsbruck, Austria.
   [Noreen, Sobia; Rai, Nadia] Islamia Univ Bahawalpur, Fac Pharm, Dept Pharmaceut, Bahawalpur, Pakistan.
   [Farooq, Muhammad Irshad] Univ Toyama, Inst Nat Med, Grad Sch Med & Pharmaceut Sci, Toyama, Japan.
   [Qadeer, Maria] Islamia Univ Bahawalpur, Fac Pharm, Dept Pharmacol, Bahawalpur 63100, Pakistan.
   [Saeed, Mohammed N.] Garmian Polytech Univ, Kifri Tech Coll, Dept Nutr Anal & Hlth, Kifri City, Sulaimaniyah Pr, Iraq.
C3 Sulaimani Polytechnic University; University of Innsbruck; Islamia
   University of Bahawalpur; University of Toyama; Islamia University of
   Bahawalpur
RP Awlqadr, FH (corresponding author), Sulaimani Polytech Univ, Halabja Tech Coll, Dept Food Sci & Qual Control, Sulaymaniyah, Iraq.
EM aya.asfandyar@spu.edu.iq; sobianoreen07@gmail.com;
   farhang.hamid.a@spu.edu.iq; Irshadfarooq93@gmail.com;
   mariaqadeer32@gmail.com; nadiarai.phd@gmail.com; halgurd.ali@spu.edu.iq;
   mohammed.noori@gpu.edu.iq
RI Madni, Prof. Dr. M. Asadullah/ABD-4544-2022; Awlqadr,
   Farhang/KCK-1023-2024; Farooq, Muhammad/HLW-9266-2023
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NR 204
TC 0
Z9 0
U1 4
U2 4
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1606-0997
EI 2072-1315
J9 J HEALTH POPUL NUTR
JI J. Heatlh Popul. Nutr.
PD MAY 2
PY 2025
VL 44
IS 1
AR 143
DI 10.1186/s41043-025-00899-y
PG 25
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA 2EA0I
UT WOS:001480407600001
PM 40317096
DA 2025-06-11
ER

PT J
AU Sonnenschein, K
   Horváth, T
   Mueller, M
   Markowski, A
   Siegmund, T
   Jacob, C
   Drexler, H
   Landmesser, U
AF Sonnenschein, Kristina
   Horvath, Tibor
   Mueller, Maja
   Markowski, Andrea
   Siegmund, Tina
   Jacob, Christian
   Drexler, Helmut
   Landmesser, Ulf
TI Exercise training improves in vivo endothelial repair capacity of
   early endothelial progenitor cells in subjects with metabolic syndrome
SO EUROPEAN JOURNAL OF CARDIOVASCULAR PREVENTION & REHABILITATION
LA English
DT Article
DE Endothelial progenitor cells; endothelial function; exercise training;
   metabolic syndrome; nitric oxide; oxidative stress
ID CORONARY-ARTERY-DISEASE; NITRIC-OXIDE SYNTHASE; VASCULAR OXIDATIVE
   STRESS; CHRONIC HEART-FAILURE; PHYSICAL-ACTIVITY; NEOINTIMA FORMATION;
   ACCELERATES REENDOTHELIALIZATION; CARDIOVASCULAR EVENTS; SCIENTIFIC
   STATEMENT; NAD(P)H OXIDASE
AB Background: Endothelial dysfunction and injury are considered to contribute considerably to the development and progression of atherosclerosis. It has been suggested that intense exercise training can increase the number and angiogenic properties of early endothelial progenitor cells (EPCs). However, whether exercise training stimulates the capacity of early EPCs to promote repair of endothelial damage and potential underlying mechanisms remain to be determined. The present study was designed to evaluate the effects of moderate exercise training on in vivo endothelial repair capacity of early EPCs, and their nitric oxide and superoxide production as characterized by electron spin resonance spectroscopy analysis in subjects with metabolic syndrome.
   Methods and results: Twenty-four subjects with metabolic syndrome were randomized to an 8 weeks exercise training or a control group. Superoxide production and nitric oxide (NO) availability of early EPCs were characterized by using electron spin resonance (ESR) spectroscopy analysis. In vivo endothelial repair capacity of EPCs was examined by transplantation into nude mice with defined carotid endothelial injury. Endothelium-dependent, flow-mediated vasodilation was analysed using high-resolution ultrasound. Importantly, exercise training resulted in a substantially improved in vivo endothelial repair capacity of early EPCs (24.0 vs 12.7%; p<0.05) and improved endothelium-dependent vasodilation. Nitric oxide production of EPCs was substantially increased after exercise training, but not in the control group. Moreover, exercise training reduced superoxide production of EPCs, which was not observed in the control group.
   Conclusions: The present study suggests for the first time that moderate exercise training increases nitric oxide production of early endothelial progenitor cells and reduces their superoxide production. Importantly, this is associated with a marked beneficial effect on the in vivo endothelial repair capacity of early EPCs in subjects with metabolic syndrome.
C1 [Mueller, Maja; Landmesser, Ulf] Univ Zurich Hosp, Ctr Cardiovasc, Dept Cardiol, CH-8091 Zurich, Switzerland.
   [Sonnenschein, Kristina; Horvath, Tibor; Mueller, Maja; Markowski, Andrea; Siegmund, Tina; Jacob, Christian; Drexler, Helmut; Landmesser, Ulf] Hannover Med Sch, Klin Kardiol & Angiol, D-30623 Hannover, Germany.
   [Markowski, Andrea] Hannover Med Sch, Klin Gastroenterol Hepatol & Endokrinol, D-30623 Hannover, Germany.
C3 University of Zurich; University Zurich Hospital; Hannover Medical
   School; Hannover Medical School
RP Landmesser, U (corresponding author), Univ Zurich Hosp, Ctr Cardiovasc, Dept Cardiol, Raemistr 100, CH-8091 Zurich, Switzerland.
EM Ulf.Landmesser@usz.ch
RI Landmesser, Ulf/NJT-0954-2025
FU Deutsche Forschungsgemeinschaft (DFG) [LA 1432/4-1]
FX This work was supported by Deutsche Forschungsgemeinschaft (DFG, LA
   1432/4-1). ClinicalTrials.gov Identifier: NCT 00515476.
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NR 46
TC 29
Z9 32
U1 0
U2 1
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1741-8267
J9 EUR J CARDIOV PREV R
JI Eur. J. Cardiovasc. Prev. Rehabil.
PD JUN
PY 2011
VL 18
IS 3
BP 406
EP 414
DI 10.1177/1741826710389373
PG 9
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 769OM
UT WOS:000291026100008
PM 21450652
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Thurston, RC
   Keefe, FJ
   Bradley, L
   Krishnan, KRR
   Caldwell, DS
AF Thurston, RC
   Keefe, FJ
   Bradley, L
   Krishnan, KRR
   Caldwell, DS
TI Chest pain in the absence of coronary artery disease: A biopsychosocial
   perspective
SO PAIN
LA English
DT Review
ID COGNITIVE-BEHAVIORAL THERAPY; CARDIAC SYNDROME-X; ANGINA-PECTORIS;
   ENDOTHELIAL DYSFUNCTION; PSYCHOLOGICAL TREATMENT; RANDOMIZED TRIAL;
   ANGIOGRAMS; STRESS; WOMEN; PATHOPHYSIOLOGY
C1 Duke Univ, Med Ctr, Durham, NC 27710 USA.
   Univ Alabama, Birmingham, AL 35294 USA.
C3 Duke University; University of Alabama System; University of Alabama
   Birmingham
RP Keefe, FJ (corresponding author), Duke Univ, Med Ctr, Box 3159, Durham, NC 27710 USA.
OI Bradley, Laurence/0000-0002-1206-2263
FU NIDDK NIH HHS [R01 DK42428-09] Funding Source: Medline; NIMH NIH HHS
   [R01 MH63429-01] Funding Source: Medline
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NR 53
TC 14
Z9 16
U1 0
U2 3
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0304-3959
J9 PAIN
JI Pain
PD AUG
PY 2001
VL 93
IS 2
BP 95
EP 100
DI 10.1016/S0304-3959(01)00327-X
PG 6
WC Anesthesiology; Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Anesthesiology; Neurosciences & Neurology
GA 451LY
UT WOS:000169804600001
PM 11427319
DA 2025-06-11
ER

PT J
AU Li, C
   Xing, JJ
   Shan, AQ
   Leng, L
   Liu, JC
   Yue, S
   Yu, H
   Chen, X
   Tian, FS
   Tang, NJ
AF Li, Chen
   Xing, Jing-Jing
   Shan, An-Qi
   Leng, Ling
   Liu, Jin-Chuan
   Yue, Song
   Yu, Hao
   Chen, Xi
   Tian, Feng-Shi
   Tang, Nai-Jun
TI Increased risk of nonalcoholic fatty liver disease with occupational
   stress in Chinese policemen A 4-year cohort study
SO MEDICINE
LA English
DT Article
DE cohort study; nonalcoholic fatty liver disease; occupational stress;
   police officers
ID CORONARY-HEART-DISEASE; QUALITY-OF-LIFE; PHYSICAL-ACTIVITY; METABOLIC
   SYNDROME; PSYCHOLOGICAL DISTRESS; CARDIOVASCULAR-DISEASE; UNITED-STATES;
   DEPRESSION; OFFICERS; PREVALENCE
AB Nonalcoholic fatty liver disease (NAFLD) and occupational stress have been recognized as major public health concerns. We aimed to explore whether occupational stress was associated with NAFLD in a police population.
   A total of 6559 male police officers were recruited for this prospective study in April 2007. Among them, 2367 eligible subjects participated in follow-up from 2008 to 2011. NAFLD was diagnosed based on standard criteria. Occupational stress was evaluated by Occupational Stress Inventory-Revised scores.
   The incidence of NAFLD was 31.2% in the entire police. After adjusting for traditional risk factors, moderate occupational stress (MOS), high occupational stress (HOS), and high personal strain (HPS) were risk factors (MOS: hazard ratio [HR]=1.237, 95% confidence interval [CI]=1.049-1.460; HOS: HR=1.727, 95% CI=1.405-2.124; HPS: HR=3.602, 95% CI=1.912-6.787); and low occupational stress (LOS) and low personal strain (LPS) were protective factors (LOS: HR=0.366, 95% CI=0.173-0.776; LPS: HR=0.490, 95% CI=0.262-0.919) for NAFLD in the entire police cohort.
   HOS and HPS remained robust among traffic police. HOS and HPS were independent predictors for the development of NAFLD in a Chinese police population. Additional future prospective investigations are warranted to validate our findings.
C1 [Li, Chen; Xing, Jing-Jing; Shan, An-Qi; Leng, Ling; Liu, Jin-Chuan; Chen, Xi; Tang, Nai-Jun] Tianjin Med Univ, Sch Publ Hlth, Dept Occupat & Environm Hlth, Qixiangtai Rd 22, Heping 300070, Tianjin, Peoples R China.
   [Yue, Song; Tian, Feng-Shi] Police Hosp, Med Ctr, Dept Phys Examinat, Heping, Peoples R China.
   [Yu, Hao] Tianjin Ctr Dis Control & Prevent, Hedong, Peoples R China.
   [Tian, Feng-Shi] Tianjin 4th Ctr Hosp, Dept Cardiovasc Med, Zhongshan Rd 3, Tianjin, Hebei, Peoples R China.
C3 Tianjin Medical University; Tianjin Center for Disease Control &
   Prevention
RP Tang, NJ (corresponding author), Tianjin Med Univ, Sch Publ Hlth, Dept Occupat & Environm Hlth, Qixiangtai Rd 22, Heping 300070, Tianjin, Peoples R China.; Tian, FS (corresponding author), Tianjin 4th Ctr Hosp, Dept Cardiovasc Med, Zhongshan Rd 3, Tianjin, Hebei, Peoples R China.
EM fengshitian080101@126.com; tangnaijun@tmu.edu.cn
RI CHEN, XI/KYP-6174-2024
FU Tianjin Municipal Science and Technology Commission [08ZCGYSF01500,
   10ZCKFSF00600]
FX This study was supported by grant 08ZCGYSF01500 and 10ZCKFSF00600 from
   the Tianjin Municipal Science and Technology Commission.
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U2 27
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD NOV
PY 2016
VL 95
IS 46
AR e5359
DI 10.1097/MD.0000000000005359
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA ED3DV
UT WOS:000388730500037
PM 27861366
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Shahbaz, K
   Chang, DN
   Zhou, X
   Low, M
   Seto, SW
   Li, CG
AF Shahbaz, Kiran
   Chang, Dennis
   Zhou, Xian
   Low, Mitchell
   Seto, Sai Wang
   Li, Chung Guang
TI Crocins for Ischemic Stroke: A Review of Current Evidence
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Review
DE ischemic stroke; Crocins; saffron; neuroinflammation; antioxidant;
   molecular targets; toxicity and safety; clinical trial
ID CROCUS-SATIVUS-L.; TRANS-SODIUM CROCETINATE; GARDENIA-JASMINOIDES ELLIS;
   GLOBAL CEREBRAL-ISCHEMIA; TO-MODERATE DEPRESSION; BLOOD-BRAIN-BARRIER;
   NF-KAPPA-B; DOUBLE-BLIND; OXIDATIVE STRESS; ISCHEMIA/REPERFUSION INJURY
AB Crocins (CRs) and the related active constituents derived from Crocus sativus L. (Saffron) have demonstrated protective effects against cerebral ischemia and ischemic stroke, with various bioactivities including neuroprotection, anti-neuroinflammation, antioxidant, and cardiovascular protection. Among CRs, crocin (CR) has been shown to act on multiple mechanisms and signaling pathways involved in ischemic stroke, including mitochondrial apoptosis, nuclear factor kappa light chain enhancer of B cells pathway, S100 calcium-binding protein B, interleukin-6 and vascular endothelial growth factor-A. CR is generally safe and well-tolerated. Pharmacokinetic studies indicate that CR has poor bioavailability and needs to convert to crocetin (CC) in order to cross the blood-brain barrier. Clinical studies have shown the efficacy of saffron and CR in treating various conditions, including metabolic syndrome, depression, Alzheimer's disease, and coronary artery disease. There is evidence supporting CR as a treatment for ischemic stroke, although further studies are needed to confirm their efficacy and safety in clinical settings.
C1 [Shahbaz, Kiran; Chang, Dennis; Zhou, Xian; Low, Mitchell; Seto, Sai Wang; Li, Chung Guang] Western Sydney Univ, NICM Hlth Res Inst, Penrith, NSW, Australia.
   [Seto, Sai Wang] Hong Kong Polytech Univ, Reserach Ctr Chinese Med Innovat, Kowloon, Hong Kong, Peoples R China.
   [Seto, Sai Wang] Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Kowloon, Hong Kong, Peoples R China.
C3 Western Sydney University; Hong Kong Polytechnic University; Hong Kong
   Polytechnic University
RP Shahbaz, K; Li, CG (corresponding author), Western Sydney Univ, NICM Hlth Res Inst, Penrith, NSW, Australia.
EM k.shahbaz@westernsydney.edu.au; c.li@westernsydney.edu.au
RI zhou, xian/AAF-6449-2021; Low, Mitchell/G-9619-2019; L, CG/IXN-7372-2023
OI Zhou, Xian/0000-0001-8766-8158
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NR 285
TC 6
Z9 6
U1 2
U2 29
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD AUG 5
PY 2022
VL 13
AR 825842
DI 10.3389/fphar.2022.825842
PG 22
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 4E6HC
UT WOS:000847923400001
PM 35991882
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Nagel, G
   Arnold, FJ
   Wilhelm, M
   Link, B
   Zoellner, I
   Koenig, W
AF Nagel, Gabriele
   Arnold, Frank J.
   Wilhelm, Manfred
   Link, Bernhard
   Zoellner, Iris
   Koenig, Wolfgang
TI Environmental tobacco smoke and cardiometabolic risk in young children:
   results from a survey in south-west Germany
SO EUROPEAN HEART JOURNAL
LA English
DT Article
DE Leptin; Adiponectin; Apolipoproteins; Inflammation; Environmental
   tobacco smoke; Children
ID CORONARY-HEART-DISEASE; SECONDHAND SMOKE; MATERNAL SMOKING; PASSIVE
   SMOKING; CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; CIGARETTE-SMOKING;
   OXIDATIVE STRESS; EXPOSURE; INFLAMMATION
AB We explored the association between exposure to environmental tobacco smoke (ETS) and various cardiometabolic biomarkers in 10-year-old children.
   A population-based cross-sectional study was carried out. Data on ETS exposure and potential confounders were collected by parental questionnaire. Adiponectin, leptin, markers of inflammation, apolipoproteins (apo) AI and B, and lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) were measured. Linear and logistic regression models were applied using the 90th percentile as a cut-off point except for adiponectin and apoAI (10th percentile). In linear models, ETS exposure was significantly associated with increasing plasma concentrations of leptin, C-reactive protein, fibrinogen, interleukin (IL)-6, and Lp-PLA(2). When compared with none, ETS exposure of more than 10 cigarettes per day was associated with elevated concentrations of leptin (OR 6.40; 95% CI, 2.67-15.39), C-reactive protein (OR 3.17; 95% CI, 1.31-7.68), Lp-PLA(2) (OR 2.97 95% CI, 1.32-6.68), low adiponectin (OR 2.69; 95% CI, 1.10-6.57), and low apoAI (OR 4.48; 95% CI, 2.16-10.85). Increasing dose of ETS exposure was related to an increasing number of abnormal cardiometabolic markers.
   Among children, ETS exposure was associated with a low-grade inflammatory response and altered markers of lipid metabolism, which may initiate atherosclerosis in early life. However, longitudinal studies are necessary to determine the potential causal relevance of these associations.
C1 [Nagel, Gabriele] Univ Ulm, Inst Epidemiol, D-89081 Ulm, Germany.
   [Wilhelm, Manfred] Ulm Univ Appl Sci, Inst Informat Med Documentat & Stat, Ulm, Germany.
   [Link, Bernhard; Zoellner, Iris] Baden Wurttemberg State Hlth Off, Stuttgart, Germany.
   [Arnold, Frank J.; Koenig, Wolfgang] Univ Ulm, Med Ctr, Dept Internal Med Cardiol 2, D-89081 Ulm, Germany.
C3 Ulm University; Ulm University; Ulm University
RP Nagel, G (corresponding author), Univ Ulm, Inst Epidemiol, Helmholtzstr 22, D-89081 Ulm, Germany.
EM gabriele.nagel@uni-ulm.de
RI Koenig, Wolfgang/JCF-0788-2023; Nagel, Gabriele/C-3635-2012
OI Koenig, Wolfgang/0000-0002-2064-9603
CR Apfelbacher CJ, 2008, BMC PUBLIC HEALTH, V8, DOI 10.1186/1471-2458-8-171
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NR 43
TC 26
Z9 27
U1 0
U2 6
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0195-668X
EI 1522-9645
J9 EUR HEART J
JI Eur. Heart J.
PD AUG
PY 2009
VL 30
IS 15
BP 1885
EP 1893
DI 10.1093/eurheartj/ehp180
PG 9
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 481JN
UT WOS:000268806100018
PM 19468010
OA Bronze
DA 2025-06-11
ER

PT J
AU Agrawal, S
   Mehta, PK
   Merz, CNB
AF Agrawal, Shilpa
   Mehta, Puja K.
   Merz, C. Noel Bairey
TI Cardiac Syndrome X: Update
SO HEART FAILURE CLINICS
LA English
DT Review
DE Cardiac syndrome X; Angina; Ischemia; Microvascular endothelial
   dysfunction; Myocardial hypersensitivity
ID NORMAL CORONARY-ARTERIES; CONVERTING ENZYME-INHIBITION; SYNDROME
   EVALUATION WISE; ENHANCED EXTERNAL COUNTERPULSATION; CARDIOVASCULAR
   MAGNETIC-RESONANCE; LEFT-VENTRICULAR FUNCTION; CALCIUM-CHANNEL BLOCKER;
   STABLE ANGINA-PECTORIS; CHEST-PAIN; MYOCARDIAL-ISCHEMIA
AB Cardiac Syndrome X (CSX), characterized by angina-like chest discomfort, ST segment depression during exercise, and normal epicardial coronary arteries at angiography, is highly prevalent in women. CSX is not benign, and linked to adverse cardiovascular outcomes and a poor quality of life. Coronary microvascular and endothelial dysfunction and abnormal cardiac nociception have been implicated in the pathogenesis of CSX. Treatment includes life-style modification, anti-anginal, anti-atherosclerotic, and anti-ischemic medications. Non-pharmacological options include cognitive behavioral therapy, enhanced external counterpulsation, neurostimulation, and stellate ganglionectomy. Studies have shown the efficacy of individual treatments but guidelines outlining the best course of therapy are lacking.
C1 [Agrawal, Shilpa] Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90095 USA.
   [Mehta, Puja K.; Merz, C. Noel Bairey] Cedars Sinai Med Ctr, Dept Med, Barbra Streisand Womens Heart Ctr, Cedars Sinai Heart Inst, Los Angeles, CA 90048 USA.
C3 University of California System; University of California Los Angeles;
   University of California Los Angeles Medical Center; David Geffen School
   of Medicine at UCLA; Cedars Sinai Medical Center
RP Mehta, PK (corresponding author), 127 South San Vicente Blvd,Suite A3212, Los Angeles, CA 90048 USA.
EM puja.mehta@cshs.org
OI Bairey Merz, C. Noel/0000-0002-9933-5155
FU National Heart, Lung, and Blood Institute [N01-HV-68161, N01-HV-68162,
   N01-HV-68163, N01-HV-68164]; National Institute on Aging [K23HL105787,
   U0164829, U01 HL649141, U01 HL649241, T32HL69751, R01 HL090957,
   1R03AG032631]; GCRC from the National Center for Research Resources
   [MO1-RR00425]; Gustavus and Louis Pfeiffer Research Foundation,
   Danville, NJ; Women's Guild of Cedars-Sinai Medical Center, Los Angeles,
   CA; Ladies Hospital Aid Society of Western Pennsylvania, Pittsburgh, PA;
   QMED, Laurence Harbor, NJ; Edythe L. Broad Women's Heart Research
   Fellowship, Cedars-Sinai Medical Center, Los Angeles, California; Barbra
   Streisand Women's Cardiovascular Research and Education Program,
   Cedars-Sinai Medical Center, Los Angeles; Linda Joy Pollin Women's Heart
   Health Program, Cedars-Sinai Medical Center, Los Angeles
FX This work was supported by contracts from the National Heart, Lung, and
   Blood Institute, N01-HV-68161, N01-HV-68162, N01-HV-68163, N01-HV-68164,
   grants K23HL105787, U0164829, U01 HL649141, U01 HL649241, T32HL69751,
   R01 HL090957, 1R03AG032631 from the National Institute on Aging, GCRC
   grant MO1-RR00425 from the National Center for Research Resources and
   grants from the Gustavus and Louis Pfeiffer Research Foundation,
   Danville, NJ, The Women's Guild of Cedars-Sinai Medical Center, Los
   Angeles, CA, The Ladies Hospital Aid Society of Western Pennsylvania,
   Pittsburgh, PA, and QMED, Laurence Harbor, NJ, the Edythe L. Broad
   Women's Heart Research Fellowship, Cedars-Sinai Medical Center, Los
   Angeles, California, and the Barbra Streisand Women's Cardiovascular
   Research and Education Program, Cedars-Sinai Medical Center, Los
   Angeles, and the Linda Joy Pollin Women's Heart Health Program,
   Cedars-Sinai Medical Center, Los Angeles.
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NR 112
TC 25
Z9 28
U1 0
U2 19
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1551-7136
J9 HEART FAIL CLIN
JI Heart Fail. Clin.
PD JAN
PY 2016
VL 12
IS 1
BP 141
EP +
DI 10.1016/j.hfc.2015.08.012
PG 17
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA CW6NI
UT WOS:000365113900011
PM 26567981
DA 2025-06-11
ER

PT J
AU Toblli, JE
   Cao, G
   Rivas, C
   Munoz, M
   Giani, J
   Dominici, F
   Angerosa, M
AF Toblli, Jorge E.
   Cao, Gabriel
   Rivas, Carlos
   Munoz, Marina
   Giani, Jorge
   Dominici, Fernando
   Angerosa, Margarita
TI Cardiovascular protective effects of nebivolol in Zucker diabetic fatty
   rats
SO JOURNAL OF HYPERTENSION
LA English
DT Article
DE aorta; beta-blockers; heart; metabolic syndrome; Zucker diabetic fatty
   rat
ID SPONTANEOUSLY HYPERTENSIVE-RATS; METABOLIC SYNDROME; NITRIC-OXIDE;
   IN-VIVO; PLATELET-AGGREGATION; ENDOTHELIAL-CELLS; OXIDATIVE STRESS;
   SUPEROXIDE; ACTIVATION; MODEL
AB Background Although effective in reducing blood pressure, therapy with a first-generation beta-blocker is currently controversial in metabolic syndrome due to its negative impact on carbohydrate and lipid metabolism. Objective and design We evaluated the effects of nebivolol, a third-generation highly selective beta-blocker with additional vasodilating activity, versus the traditional beta-blocker atenolol in controlling functional and morphological cardiovascular damage in a rat model of metabolic syndrome.
   Methods During 6 months, Zucker diabetic fatty (ZDF) rats and control lean Zucker rats (LZR) were studied. The experimental groups were: untreated ZDF, ZDF along with nebivolol, ZDF along with atenolol and LZR. Blood pressure, plasma insulin, triglycerides, cholesterol, glucose and platelet aggregation were evaluated. Malondialdehyde, reduced glutathione (GSH)/oxidized glutathione ( GSSG) ratio, CuZn superoxide dismutase, catalase and glutathione peroxidase were determined in heart homogenates and transforming growth factor beta(1) and plasminogen activator inhibitor-1 (PAI-1) expression, by immunohistochemistry (IHC). Vascular reactivity, vascular cell adhesion molecule-1, platelet endothelial cell adhesion molecule-1, PAI-1, enhanced nitric oxide synthase and collagen expression were evaluated in aorta.
   Results Nebivolol and atenolol presented a similar reduction in blood pressure. However, nebivolol showed a better lipid profile, preserved left ventricular function, a significant control in left ventricular geometry and moderated left ventricular hypertrophy versus atenolol. Significant reduction in platelet aggregation and a substantial endothelium-dependent and endothelium-independent relaxation in vessels were also shown in the nebivolol group versus atenolol group. Antioxidant defenses were preserved by nebivolol with a reduction in oxidative stress parameters. Vascular cell adhesion molecule-1, platelet endothelial cell adhesion molecule-1, PAI-1 and eNOS were favorably modulated with nebivolol in vessel wall. TGF beta(1), PAI-1 and accumulation of collagen-III and collagen-I were also diminished in heart with nebivolol.
   Conclusion The present study provides substantial information supporting an actual protective role of nebivolol in comparison with atenolol in experimental metabolic syndrome. J Hypertens 28:1007-1019 (C) 2010 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
C1 [Toblli, Jorge E.; Cao, Gabriel; Rivas, Carlos; Angerosa, Margarita] Hosp Aleman, Expt Med Lab, RA-1118 Buenos Aires, DF, Argentina.
   [Munoz, Marina; Giani, Jorge; Dominici, Fernando] Univ Buenos Aires, Sch Pharm & Biochem, IQUIFIB, Buenos Aires, DF, Argentina.
C3 Hospital Aleman; University of Buenos Aires; University of Buenos Aires
   Hospital; University of Buenos Aires
RP Toblli, JE (corresponding author), Hosp Aleman, Expt Med Lab, Av Pueyrredon 1640, RA-1118 Buenos Aires, DF, Argentina.
EM jorgetoblli@fibertel.com.ar
RI Cao, Gabriel/LJL-8755-2024
OI Giani, Jorge/0000-0003-0481-6595; Dominici, Fernando
   Pablo/0000-0002-4351-0057; Cao, Gabriel/0000-0003-4671-9048
FU Consejo Nacional de Investigaciones Cientificas y Tecnologicas of
   Argentina (CONICET); University of Buenos Aires (UBA); Agencia Nacional
   de Promocion Cientifica y Tecnologica of Argentina
FX J.E.T. and F.P.D. are career investigators from Consejo Nacional de
   Investigaciones Cientificas y Tecnologicas of Argentina (CONICET) and
   received grant support from the University of Buenos Aires (UBA),
   CONICET and Agencia Nacional de Promocion Cientifica y Tecnologica of
   Argentina. M.C.M. is a research fellow from CONICET, and J.F.G. is a
   research fellow from UBA.
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NR 44
TC 37
Z9 42
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0263-6352
J9 J HYPERTENS
JI J. Hypertens.
PD MAY
PY 2010
VL 28
IS 5
BP 1007
EP 1019
DI 10.1097/HJH.0b013e328337598c
PG 13
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 583UX
UT WOS:000276706500020
PM 20411618
DA 2025-06-11
ER

PT J
AU Gladigau, EL
   Fazio, TN
   Hannam, JP
   Dawson, LM
   Jones, SG
AF Gladigau, E. L.
   Fazio, T. N.
   Hannam, J. P.
   Dawson, L. M.
   Jones, S. G.
TI Increased cardiovascular risk in patients with severe mental illness
SO INTERNAL MEDICINE JOURNAL
LA English
DT Article
DE severe mental illness; cardiovascular; metabolic; mortality
ID METABOLIC SYNDROME; LIFE-STYLE; SCHIZOPHRENIA; PEOPLE; PREVALENCE;
   OBESITY; EXPECTANCY; MORTALITY; SERVICE; ADULTS
AB BackgroundPeople with severe mental illness (SMI) have a reduced life expectancy. A major cause of mortality is cardiovascular disease.
   AimsThe aims of this study were to document the prevalence of cardiovascular risk factors in people with SMI engaged in community psychiatric rehabilitation and compare prevalence rates to the general, and Aboriginal and Torres Strait Islander (ATSI) populations of Australia.
   MethodA cross-sectional audit was conducted on patients receiving care from Melbourne's Inner-West Area Mental Health Service. Profiles were collected on: smoking status, body mass index, waist circumference, blood pressure, diabetic status and fasting lipid profiles. These were compared with the general and ATSI Australian populations.
   ResultsComplete data were available for 60 patients. Most were involuntary patients with a diagnosis of schizophrenia or schizoaffective disorder. Patients were more likely to smoke, be obese, have dyslipidaemia and the metabolic syndrome compared with the general and ATSI populations of Australia. Patients were more likely to have diabetes than the general population but had similar rates to the ATSI population. Patients had similar rates of hypertension to the general population but were less likely to be hypertensive compared with the ATSI population.
   ConclusionAustralians living with SMI have very high rates of cardiovascular risk factors, far in excess of the general Australian population and comparable with the ATSI population.
C1 [Gladigau, E. L.] Westcare Med Ctr, Melbourne, Vic, Australia.
   [Fazio, T. N.] Melbourne Hlth, Melbourne, Vic, Australia.
   [Dawson, L. M.; Jones, S. G.] Melbourne Hlth, Inner West Area Mental Hlth Serv, Melbourne, Vic, Australia.
   [Hannam, J. P.] North Western Mental Hlth, Melbourne, Vic, Australia.
C3 Melbourne Health; Melbourne Health
RP Gladigau, EL (corresponding author), Westcare Med Ctr, 1-211 Barries Rd, Melton West, Vic 3337, Australia.
EM e.gladigau@gmail.com
RI Fazio, Timothy/M-6037-2018
OI Fazio, Timothy/0000-0003-1700-2355
CR Australian Bureau of Statistics, 4364 0 NAT HLTH SURV
   Australian Bureau of Statistics, 2009, 4714 0 NAT AB TORR S, V4714.0
   Briganti EM, 2003, MED J AUSTRALIA, V179, P135, DOI 10.5694/j.1326-5377.2003.tb05471.x
   Burns J., 2006, Summary of Overweight and Obesity Among Indigenous peoples
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   Cameron AJ, 2007, DIABETES RES CLIN PR, V77, P471, DOI 10.1016/j.diabres.2007.02.002
   Cardiovascular Expert Group, 2008, THER GUID CARD DYSL
   Cooke M, 2007, BMC INT HEALTH HUM R, V20, P9
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   De Hert M, 2009, WORLD PSYCHIATRY, V8, P15
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NR 27
TC 31
Z9 33
U1 0
U2 21
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1444-0903
EI 1445-5994
J9 INTERN MED J
JI Intern. Med. J.
PD JAN
PY 2014
VL 44
IS 1
BP 65
EP 69
DI 10.1111/imj.12319
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA 293RC
UT WOS:000329990400010
PM 24383746
DA 2025-06-11
ER

PT J
AU Pereira, VH
   Marques, F
   Lages, V
   Pereira, FG
   Patchev, A
   Almeida, OFX
   Almeida-Palha, J
   Sousa, N
   Cerqueira, JJ
AF Pereira, Vitor H.
   Marques, Fernanda
   Lages, Vania
   Pereira, Filipa G.
   Patchev, Alexandre
   Almeida, Osborne F. X.
   Almeida-Palha, Joana
   Sousa, Nuno
   Cerqueira, Joao J.
TI Glucose intolerance after chronic stress is related with downregulated
   PPAR-γ in adipose tissue
SO CARDIOVASCULAR DIABETOLOGY
LA English
DT Article
DE Chronic unpredictable stress; Glucose intolerance; Metabolic syndrome;
   PPAR; Lipocalin-2; White adipose tissue
ID ACTIVATED-RECEPTOR-GAMMA; PEROXISOME-PROLIFERATOR; INSULIN-RESISTANCE;
   METABOLIC SYNDROME; NEUROPEPTIDE-Y; OXIDATIVE STRESS; INDUCED OBESITY;
   LIPOCALIN 2; INFLAMMATION; DIET
AB Background: Chronic stress is associated with increased risk of glucose intolerance and cardiovascular diseases, albeit through undefined mechanisms. With the aim of gaining insights into the latter, this study examined the metabolic profile of young adult male rats that were exposed to chronic unpredictable stress.
   Methods: Young adult male rats were submitted to 4 weeks of chronic unpredictable stress and allowed to recover for 5 weeks. An extensive analysis including of morphologic, biochemical and molecular parameters was carried out both after chronic unpredictable stress and after recovery from stress.
   Results: After 28 days of chronic unpredictable stress (CUS) the animals submitted to this protocol displayed less weight gain than control animals. After 5 weeks of recovery the weight gain rebounded to similar values of controls. In addition, following CUS, fasting insulin levels were increased and were accompanied by signs of impaired glucose tolerance and elevated serum corticosteroid levels. This biochemical profile persisted into the post-stress recovery period, despite the restoration of baseline corticosteroid levels. The mRNA expression levels of peroxisome proliferator-activated receptor (PPAR)-gamma and lipocalin-2 in white adipose tissue were, respectively, down-and up-regulated.
   Conclusions: Reduction of PPAR-gamma expression and generation of a pro-inflammatory environment by increased lipocalin-2 expression in white adipose tissue may contribute to stress-induced glucose intolerance.
C1 [Pereira, Vitor H.; Marques, Fernanda; Lages, Vania; Pereira, Filipa G.; Almeida-Palha, Joana; Sousa, Nuno; Cerqueira, Joao J.] Univ Minho, Sch Hlth Sci, Life & Hlth Sci Res Inst ICVS, Campus Gualtar, P-4710057 Braga, Portugal.
   [Pereira, Vitor H.; Marques, Fernanda; Lages, Vania; Pereira, Filipa G.; Almeida-Palha, Joana; Sousa, Nuno; Cerqueira, Joao J.] ICVS 3Bs PT Govt, Associate Lab, Braga, Portugal.
   [Patchev, Alexandre; Almeida, Osborne F. X.] Max Planck Inst Psychiat, Munich, Germany.
C3 Universidade do Minho; Max Planck Society
RP Sousa, N (corresponding author), Univ Minho, Sch Hlth Sci, Life & Hlth Sci Res Inst ICVS, Campus Gualtar, P-4710057 Braga, Portugal.; Sousa, N (corresponding author), ICVS 3Bs PT Govt, Associate Lab, Braga, Portugal.
EM njcsousa@ecsaude.uminho.pt
RI Marques, Fernanda/D-4238-2012; Pereira, Filipa/N-1759-2013; Almeida,
   Osborne/E-8402-2010; Pereira, Vitor/MSV-8475-2025; Palha,
   Joana/C-2745-2009; Sousa, Nuno/N-9137-2017; Cerqueira, Joao/B-4579-2008
OI Almeida, Osborne F.X./0000-0001-7331-6928; Marques,
   Fernanda/0000-0002-3612-1870; Pereira, Vitor/0000-0002-9314-0453; Palha,
   Joana/0000-0002-8866-368X; Sousa, Nuno/0000-0002-8755-5126; Cerqueira,
   Joao/0000-0003-3155-2775
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NR 48
TC 28
Z9 31
U1 0
U2 5
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1475-2840
J9 CARDIOVASC DIABETOL
JI Cardiovasc. Diabetol.
PD AUG 19
PY 2016
VL 15
AR 114
DI 10.1186/s12933-016-0433-2
PG 11
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism
GA DW7MU
UT WOS:000383835800001
PM 27538526
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Duarte-Díaz, A
   Perestelo-Pérez, L
   Rivero-Santana, A
   Peñate, W
   Alvarez-Pérez, Y
   Ramos-García, V
   González-Pacheco, H
   Goya-Arteaga, L
   de Bonis-Braun, M
   González-Martín, S
   Ramallo-Fariña, Y
   Carrion, C
   Serrano-Aguilar, P
AF Duarte-Diaz, Andrea
   Perestelo-Perez, Lilisbeth
   Rivero-Santana, Amado
   Penate, Wenceslao
   Alvarez-Perez, Yolanda
   Ramos-Garcia, Vanesa
   Gonzalez-Pacheco, Himar
   Goya-Arteaga, Libertad
   de Bonis-Braun, Miriam
   Gonzalez-Martin, Silvia
   Ramallo-Farina, Yolanda
   Carrion, Carme
   Serrano-Aguilar, Pedro
TI The relationship between patient empowerment and related constructs,
   affective symptoms and quality of life in patients with type 2 diabetes:
   a systematic review and meta-analysis
SO FRONTIERS IN PUBLIC HEALTH
LA English
DT Review
DE empowerment; diabetes; affective outcomes; quality of life; systematic
   review and meta-analysis; self-efficacy
ID SELF-CARE ACTIVITIES; BODY-MASS INDEX; GLYCEMIC CONTROL; SOCIAL SUPPORT;
   GLYCOSYLATED HEMOGLOBIN; DEPRESSION SYMPTOMS; METABOLIC SYNDROME;
   AFRICAN-AMERICANS; PERCEIVED CONTROL; HEALTH LITERACY
AB Introduction: The aim of this systematic review is to assess the relationship between patient empowerment and other empowerment-related constructs, and affective symptoms and quality of life in patients with type 2 diabetes.
   Methods: A systematic review of the literature was conducted, according to the PRISMA guidelines. Studies addressing adult patients with type 2 diabetes and reporting the association between empowerment-related constructs and subjective measures of anxiety, depression and distress, as well as self-reported quality of life were included. The following electronic databases were consulted from inception to July 2022: Medline, Embase, PsycINFO, and Cochrane Library. The methodological quality of the included studies was analyzed using validated tools adapted to each study design. Meta-analyses of correlations were performed using an inverse variance restricted maximum likelihood random effects.
   Results: The initial search yielded 2463 references and seventy-one studies were finally included. We found a weak-to-moderate inverse association between patient empowerment-related constructs and both anxiety (r = -0.22) and depression ( r = -0.29). Moreover, empowerment-related constructs were moderately negatively correlated with distress ( r = -0.31) and moderately positively correlated with general quality of life ( r = 0.32). Small associations between empowerment-related constructs and both mental ( r = 0.23) and physical quality of life ( r = 0.13) were also reported.
   Discussion: This evidence is mostly from cross-sectional studies. High-quality prospective studies are needed not only to better understand the role of patient empowerment but to assess causal associations. The results of the study highlight the importance of patient empowerment and other empowermentrelated constructs such as self-efficacy or perceived control in diabetes care. Thus, they should be considered in the design, development and implementation of effecive interventions and policies aimed at improving psychosocial outcomes in patients with type 2 diabetes.
C1 [Duarte-Diaz, Andrea; Rivero-Santana, Amado; Alvarez-Perez, Yolanda; Ramos-Garcia, Vanesa; Gonzalez-Pacheco, Himar; Ramallo-Farina, Yolanda] Canary Isl Hlth Res Inst Fdn FIISC, Tenerife, Spain.
   [Duarte-Diaz, Andrea; Penate, Wenceslao] Univ La Laguna, Dept Clin Psychol Psychobiol & Methodol, ULL, Tenerife, Spain.
   [Duarte-Diaz, Andrea; Perestelo-Perez, Lilisbeth; Rivero-Santana, Amado; Alvarez-Perez, Yolanda; Ramos-Garcia, Vanesa; Gonzalez-Pacheco, Himar; Ramallo-Farina, Yolanda; Carrion, Carme; Serrano-Aguilar, Pedro] Network Res Chron Primary Care & Hlth Promot RICAP, Madrid, Spain.
   [Duarte-Diaz, Andrea; Perestelo-Perez, Lilisbeth; Rivero-Santana, Amado; Alvarez-Perez, Yolanda; Ramos-Garcia, Vanesa; Gonzalez-Pacheco, Himar; Ramallo-Farina, Yolanda; Serrano-Aguilar, Pedro] Natl Hlth Syst RedETS, Spanish Network Agcy Hlth Technol Assessment & Ser, Madrid, Spain.
   [Perestelo-Perez, Lilisbeth; Serrano-Aguilar, Pedro] Canary Isl Hlth Serv SCS, Evaluat Unit SESCS, Tenerife, Spain.
   [Goya-Arteaga, Libertad; de Bonis-Braun, Miriam; Gonzalez-Martin, Silvia] Multiprofess Unit Family & Community Care La Lagun, Tenerife, Spain.
   [Carrion, Carme] Univ Oberta Catalunya UOC, Sch Hlth Sci, eHlth Lab Res Grp, Barcelona, Spain.
C3 Universidad de la Laguna; UOC Universitat Oberta de Catalunya
RP Perestelo-Pérez, L (corresponding author), Network Res Chron Primary Care & Hlth Promot RICAP, Madrid, Spain.; Perestelo-Pérez, L (corresponding author), Natl Hlth Syst RedETS, Spanish Network Agcy Hlth Technol Assessment & Ser, Madrid, Spain.; Perestelo-Pérez, L (corresponding author), Canary Isl Hlth Serv SCS, Evaluat Unit SESCS, Tenerife, Spain.
RI Perestelo-Perez, Lilisbeth/C-6439-2011; Peñate, Wenceslao/GYJ-6621-2022;
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NR 139
TC 4
Z9 4
U1 1
U2 5
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 2296-2565
J9 FRONT PUBLIC HEALTH
JI Front. Public Health
PD APR 17
PY 2023
VL 11
AR 1118324
DI 10.3389/fpubh.2023.1118324
PG 26
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA F2HW4
UT WOS:000980617100001
PM 37139389
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Giménez-Palomo, A
   Gomes-da-Costa, S
   Dodd, S
   Pachiarotti, I
   Verdolini, N
   Vieta, E
   Berk, M
AF Gimenez-Palomo, Anna
   Gomes-da-Costa, Susana
   Dodd, Seetal
   Pachiarotti, Isabella
   Verdolini, Norma
   Vieta, Eduard
   Berk, Michael
TI Does metabolic syndrome or its component factors alter the course of
   bipolar disorder? A systematic review
SO NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
LA English
DT Review
DE Bipolar disorder; mania; depression; treatment; outcome; prognosis;
   biomarkers; medical; comorbidity; metabolic syndrome; diabetes; obesity;
   dyslipidaemia
ID BODY-MASS INDEX; TREATMENT OPTIMIZATION PROGRAM; DIABETES-MELLITUS;
   MEDICAL BURDEN; MOOD SYMPTOMS; WEIGHT-GAIN; OBESITY; MORTALITY;
   ADOLESCENTS; PREVALENCE
AB Metabolic syndrome (MetS) and its component factors, obesity, hypertension, dyslipidaemia and insulin resistance, have shown a bidirectional relationship with the prevalence and severity of bipolar disorder (BD). A systematic search of electronic databases (Pubmed, PsycINFO, clinicaltrials.gov) was conducted to explore and integrate current evidence about the role of MetS and its component factors with clinical outcomes of BD. Thirty-four articles met the inclusion criteria. Studies were grouped by the metabolic factors assessed, which included MetS, obesity and body mass index (BMI), dyslipidaemia, impaired glucose metabolism (IGM), diabetes mellitus and hypertension. They were then classified according to outcomes such as course of episodes, rapid cycling, suicidal behavior, treatment response, and global and cognitive functioning. Although current evidence remains controversial in most aspects of clinical outcomes, metabolic risk factors could alter the course of BD, with worse global functioning, poorer treatment response and a chronic course of illness, as well as enhancing rapid cycling. Further research is needed to elucidate the role of each risk factor in the mentioned outcomes.
C1 [Gimenez-Palomo, Anna; Gomes-da-Costa, Susana; Pachiarotti, Isabella; Verdolini, Norma; Vieta, Eduard] Univ Barcelona, Barcelona Bipolar Disorders Program, Hosp Clin, IDIBAPS,CIBERSAM, Barcelona, Catalunya, Spain.
   [Dodd, Seetal; Berk, Michael] Deakin Univ, IMPACT Strateg Res Ctr, Sch Med, Geelong, Vic 3320, Australia.
   [Dodd, Seetal; Berk, Michael] Univ Melbourne, Dept Psychiat, Parkville, Vic, Australia.
   [Dodd, Seetal; Berk, Michael] Univ Melbourne, Ctr Youth Mental Hlth, Parkville, Vic, Australia.
   [Berk, Michael] Univ Melbourne, Florey Inst Neurosci & Mental Hlth, Parkville, Vic, Australia.
C3 University of Barcelona; Hospital Clinic de Barcelona; IDIBAPS; CIBER -
   Centro de Investigacion Biomedica en Red; CIBERSAM; Deakin University;
   University of Melbourne; University of Melbourne; Orygen, The National
   Centre of Excellence in Youth Mental Health; University of Melbourne;
   Florey Institute of Neuroscience & Mental Health
RP Berk, M (corresponding author), Deakin Univ, IMPACT Strateg Res Ctr, Sch Med, Geelong, Vic 3320, Australia.
EM michael.berk@barwonhealth.org.au
RI Berk, Michael/AGH-9427-2022; Verdolini, Norma/AAJ-1114-2020; Vieta,
   Eduard/Y-2919-2019; Vieta, Eduard/I-6330-2013; Berk, Michael/M-7891-2013
OI PACCHIAROTTI, Isabella/0000-0002-7822-0367; Vieta,
   Eduard/0000-0002-0548-0053; Berk, Michael/0000-0002-5554-6946; Gomes da
   Costa, Susana/0000-0003-0383-0555
FU Spanish Ministry of Science and Innovation integrated into the Plan
   Nacional de I+D+I [PI15/00283, PI18/00805]; ISCIII-Subdireccion General
   de Evaluacion; Fondo Europeo de Desarrollo Regional (FEDER); Instituto
   de Salud Carlos III; CIBER of Mental Health (CIBERSAM); Secretaria
   d'Universitats i Recerca del Departament d'Economia i Coneixement [2017
   SGR 1365]; CERCA Programme; Departament de Salut de la Generalitat de
   Catalunya [SLT006/17/00357]; Spanish Ministry of Science and Innovation
   [PI18/01001]; BITRECS Project - European Union [754550]; "La Caixa"
   Foundation [100010434, LCF/PR/GN18/50310006]; NHMRC Senior Principal
   Research Fellowship [1156072]
FX Dr. Vieta thanks the support of the Spanish Ministry of Science and
   Innovation (PI15/00283, PI18/00805) integrated into the Plan Nacional de
   I+D+I and co-financed by the ISCIII-Subdireccion General de Evaluaci '
   on and the Fondo Europeo de Desarrollo Regional (FEDER); the Instituto
   de Salud Carlos III; the CIBER of Mental Health (CIBERSAM); the
   Secretaria d'Universitats i Recerca del Departament d'Economia i
   Coneixement (2017 SGR 1365), the CERCA Programme, and the Departament de
   Salut de la Generalitat de Catalunya for the PERIS grant
   SLT006/17/00357. Dr. Pacchiarotti thanks the support of the Spanish
   Ministry of Science and Innovation (PI18/01001). Dr. Verdolini research
   is supported by a BITRECS Project, which has received funding from the
   European Union's Horizon 2020 research and innovation programme under
   the Marie Sklodowska-Curie grant agreement N degrees 754550 and from "La
   Caixa" Foundation (ID 100010434), under the agreement
   LCF/PR/GN18/50310006. Dr. Berk is supported by a NHMRC Senior Principal
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NR 64
TC 38
Z9 39
U1 1
U2 22
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0149-7634
EI 1873-7528
J9 NEUROSCI BIOBEHAV R
JI Neurosci. Biobehav. Rev.
PD JAN
PY 2022
VL 132
BP 142
EP 153
DI 10.1016/j.neubiorev.2021.11.026
EA NOV 2021
PG 12
WC Behavioral Sciences; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Behavioral Sciences; Neurosciences & Neurology
GA XH8LK
UT WOS:000725679200010
PM 34800584
DA 2025-06-11
ER

PT J
AU Das, UN
AF Das, Undurti Narasimha
TI Lipoxins, resolvins, protectins, maresins and nitrolipids, and their
   clinical implications with specific reference to diabetes mellitus and
   other diseases: part II
SO CLINICAL LIPIDOLOGY
LA English
DT Review
DE antioxidant; cytokine; inflammation; lipoxin; nitric oxide; nitrolipid;
   polyunsaturated fatty acid; protectin; reactive oxygen species; resolvin
ID POLYUNSATURATED FATTY-ACIDS; C-REACTIVE PROTEIN; TUMOR-NECROSIS-FACTOR;
   METABOLIC SYNDROME-X; ADIPOSE-TISSUE INFLAMMATION; CAUSES
   INSULIN-RESISTANCE; CORONARY-HEART-DISEASE; BLOOD-PRESSURE LATER;
   ARACHIDONIC-ACID; NITRIC-OXIDE
AB Obesity, insulin resistance, essential hypertension, Type 2 diabetes, nonalcoholic fatty liver disease, coronary heart disease, osteoporosis, renal failure, Alzheimer's disease, depression, schizophrenia, aging and rheumatological conditions are low-grade systemic inflammatory conditions, in which there is an increase in the production of proinflammatory cytokines, reactive oxygen species, reactive nitrogen species and proinflammatory eicosanoids, while a decrease in the cellular antioxidants, anti-inflammatory cytokines and certain polyunsaturated fatty acids, and their anti-inflammatory products, lipoxins (LXs), resolvins (Rvs), protectins, maresins and nitrolipids, occurs. This imbalance between the pro- and anti-inflammatory molecules in these diseases suggests that therapeutic strategies directed to suppress inappropriate inflammation and enhance the synthesis/action of anti-inflammatory bioactive lipids may aid the prevention of and recovery from these diseases. It is proposed that both local and systemic delivery of LXs, Rvs, protectins, maresins and nitrolipids and/or their more stable synthetic analogs may prove to be useful in these diseases. In this part II of the review, the discussion is centered on the role of LXs, Rvs, protectins and nitrolipids in diabetes mellitus and other diseases.
C1 [Das, Undurti Narasimha] UND Life Sci, Federal Way, WA 98003 USA.
   [Das, Undurti Narasimha] Jawaharlal Nehru Technol Univ, Kakinada 533003, India.
   [Das, Undurti Narasimha] Gayatri Vidya Parishad Coll Engn, Biosci Res Ctr, Visakhapatnam 530048, Andhra Pradesh, India.
C3 Jawaharlal Nehru Technological University - Kakinada; Gayatri Vidya
   Parishad College of Engineering
RP Das, UN (corresponding author), UND Life Sci, 2020,360th St South,K 202, Federal Way, WA 98003 USA.
EM undurti@hotmail.com
RI Das, Undurti/A-7918-2009
FU Department of Biotechnology, New Delhi, India; Department of
   Biotechnology (DBT) [BT/PR11627/MED/30/157/2010]; Department of Science
   and Technology under Intensification of Research in High Priority Areas
   [IR/SO/LU/03/2008/1]; Defence Research and Development Organisation, New
   Delhi, India under RD Project [TC/2519/INM-03/2011/CARS, INM-311]
FX UN Das is in receipt of the Ramalingaswami Fellowship of the Department
   of Biotechnology, New Delhi, India, during the tenure of this study.
   This work was supported by grants from the Department of Biotechnology
   (DBT No. BT/PR11627/MED/30/157/2010), the Department of Science and
   Technology (No. IR/SO/LU/03/2008/1) under Intensification of Research in
   High Priority Areas, and the Defence Research and Development
   Organisation, New Delhi, India (TC/2519/INM-03/2011/CARS under R&D
   Project INM-311) to UN Das. The author has no other relevant
   affiliations or financial involvement with any organization or entity
   with a financial interest in or financial conflict with the subject
   matter or materials discussed in the manuscript apart from those
   disclosed.
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NR 172
TC 29
Z9 29
U1 1
U2 26
PU FUTURE MEDICINE LTD
PI LONDON
PA UNITEC HOUSE, 3RD FLOOR, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON, N3
   1QB, ENGLAND
SN 1758-4299
EI 1758-4302
J9 CLIN LIPIDOL
JI Clin. Lipidol.
PD AUG
PY 2013
VL 8
IS 4
BP 465
EP 480
DI 10.2217/CLP.13.32
PG 16
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 197ZJ
UT WOS:000322891100014
DA 2025-06-11
ER

PT J
AU Güler, GB
   Güler, E
   Hatipoglu, S
   Günes, HM
   Geçmen, Ç
   Demir, GG
   Barutçu, I
AF Guler, Gamze Babur
   Guler, Ekrem
   Hatipoglu, Suzan
   Gunes, Haci Murat
   Gecmen, Cetin
   Demir, Gultekin Gunhan
   Barutcu, Irfan
TI Assessment of 25-OH vitamin D levels and abnormal blood pressure
   response in female patients with cardiac syndrome X
SO ANATOLIAN JOURNAL OF CARDIOLOGY
LA English
DT Article
DE 25-OH vitamin D; cardiac syndrome X; abnormal blood pressure response
ID NORMAL CORONARY ARTERIOGRAMS; CARDIOVASCULAR-DISEASE; ENDOTHELIAL
   FUNCTION; ANGINA-PECTORIS; NITRIC-OXIDE; D DEFICIENCY; EXERCISE; RISK;
   HYPERTENSION; CELLS
AB Objective: Vitamin D deficiency is associated with coronary artery disease, hypertension, heart failure, endothelial dysfunction, and metabolic syndrome. The pathophysiology of cardiac syndrome X (CSX) involves many pathways that are influenced by vitamin D levels. This study aimed to investigate the relationship between vitamin D deficiency and abnormal blood pressure response to exercise in patients with CSX.
   Methods: This was a cross-sectional and observational study. Fifty females with normal epicardial coronary arteries who presented with typical symptoms of rest or effort angina and 41 healthy age-matched female controls, were included. Patients with cardiomyopathy, severe valvular disease, congenital heart disease, and left ventricular hypertrophy were excluded. All patients underwent stress electrocardiography examination and 25-hydroxy (OH) vitamin D level measurements.
   Results: Levels of 25-OH vitamin D were significantly lower in CSX patients (9.8 +/- 7.3 ng/mL vs. 18.1 +/- 7.9 ng/mL; p<0.001). Systolic blood pressure (SBP) (188 +/- 15 mm Hg vs. 179 +/- 17 mm Hg; p=0.013) and diastolic blood pressure (DBP) (98 +/- 9 mm Hg vs. 88 +/- 9 mm Hg; p<0.001) during peak exercise were higher in CSX patients. Levels of 25-OH vitamin D were negatively correlated with peak SBP (r=-0.310, p=0.004) and peak DBP (r=-0.535, p<0.001) during exercise. To discard the multicollinearity problem, two different models were used for multivariate analyses. In the first model, metabolic equivalents (METs) (p=0.003) and 25-OH vitamin D levels (p=0.001) were independent predictors. METs (p=0.007), 25-OH vitamin D levels (p=0.008), and peak DBP were determined as independent predictors in the second multivariate model.
   Conclusion: In patients with CSX, 25-OH vitamin D levels were lower than those in controls; moreover, 25-OH vitamin D deficiency was also associated with higher levels of peak DBP during exercise.
C1 [Guler, Gamze Babur; Guler, Ekrem; Gunes, Haci Murat; Demir, Gultekin Gunhan; Barutcu, Irfan] Medipol Univ, Dept Cardiol, Fac Med, Istanbul, Turkey.
   [Hatipoglu, Suzan] Ersoy Hosp, Clin Cardiol, Istanbul, Turkey.
   [Gecmen, Cetin] Kartal Kosuyolu Heart Ctr, Dept Cardiol, Istanbul, Turkey.
C3 Istanbul Medipol University; Ersoy Hospital; Istanbul Kartal Kosuyolu
   Yuksek Ihtisas Training & Research Hospital
RP Güler, GB (corresponding author), Medipol Univ, Tem Avrupa Otoyolu Goztepe Cikisi, 1 Bagcilar, Istanbul, Turkey.
EM gamzebabur@hotmail.com
RI güler, ekrem/HLQ-1313-2023; Demir, Gültekin/U-3716-2018; babur guler,
   gamze/HKN-4198-2023
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NR 34
TC 5
Z9 5
U1 0
U2 5
PU TURKISH SOC CARDIOLOGY
PI BAHCELIEVLER
PA COBANCESME SANAYI CAD NO 11, NISH ISTANBUL A BLOK KAT 8 NO 47-48,
   YENIBOSNA, BAHCELIEVLER, ISTANBUL 34196, TURKEY
SN 2149-2263
EI 2149-2271
J9 ANATOL J CARDIOL
JI Anat. J. Cardiol.
PD DEC
PY 2016
VL 16
IS 12
BP 961
EP 966
DI 10.14744/AnatolJCardiol.2016.6862
PG 6
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA EI0WT
UT WOS:000392196800014
PM 27271477
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Barsotti, S
   Saponaro, C
   Gaggini, M
   Talarico, R
   Bianchini, E
   Di Lascio, N
   Ferrari, C
   Buzzigoli, E
   Mosca, M
   Gastaldelli, A
   Neri, R
   Morales, MA
AF Barsotti, S.
   Saponaro, C.
   Gaggini, M.
   Talarico, R.
   Bianchini, E.
   Di Lascio, N.
   Ferrari, C.
   Buzzigoli, E.
   Mosca, M.
   Gastaldelli, A.
   Neri, R.
   Morales, M. A.
TI Cardiometabolic risk and subclinical vascular damage assessment in
   idiopathic inflammatory myopathies: a challenge for the clinician
SO CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
LA English
DT Article
DE idiopathic inflammatory myopathies; intima-media thickness; ultrasound;
   advanced glycation end products; polymyositis; dermatomyositis;
   cardiovascular risk
ID ADVANCED GLYCATION ENDPRODUCTS; SKIN AUTOFLUORESCENCE; METABOLIC
   SYNDROME; END-PRODUCTS; CARDIOVASCULAR-DISEASE; OXIDATIVE STRESS;
   RHEUMATOID-ARTHRITIS; ARTERIAL STIFFNESS; HIGH PREVALENCE; ADULT
   PATIENTS
AB Objective
   A high prevalence of cardiovascular disease (CVD), not fully explained by the prevalence of traditional risk factors only, is reported in patients with idiopathic inflammatory myopathies (IIMs). Thus, we investigated if novel markers of CVD risk, like carotid diameter and advanced glycated end products, can better predict increased CVD risk in IIM patients.
   Methods
   We studied 43 consecutive patients diagnosed with IIM. All the patients underwent a clinical and laboratory evaluation of cardiovascular risk factors and characterisation of myositis disease activity. Non-invasive instrumental examinations performed included the measurement of carotid parameters (intima-media thickness, IMT and mean arterial diameter, mAD) by ultrasonic techniques, advanced glycation end-product accumulation in the skin by autofluorescence (AF) and body composition by bioelectrical impedance analysis. The parameters were compared to those measured in 29 controls, with similar mean age, BMI, blood pressure and smoking habits.
   Results
   IIM patients showed normal carotid IMT and distensibility, but higher carotid mAD (p=0.012), higher skin AF (p<0.001), lower fat free mass (p=0.036) and increased waist circumference compared to controls. A significant correlation was observed among AF and mAD (rho=0.317 p<0.05), carotid distension (rho=0.391 p=0.036) and IMT (rho=0.627 p<0.001).
   Conclusion
   Abnormalities of the studied parameters suggest a higher risk of CV disease in IIM patients independent of disease activity. In this population, a thorough assessment of CV risk is recommended also in absence of overt CV disease during the clinical evaluation.
C1 [Barsotti, S.; Talarico, R.; Ferrari, C.; Mosca, M.; Neri, R.] Univ Pisa, Rheumatol Unit, Pisa, Italy.
   [Barsotti, S.] Univ Siena, Dept Med Biotechnol, Siena, Italy.
   [Saponaro, C.; Gaggini, M.; Bianchini, E.; Di Lascio, N.; Buzzigoli, E.; Gastaldelli, A.; Morales, M. A.] CNR, Inst Clin Physiol, Pisa, Italy.
   [Di Lascio, N.; Gastaldelli, A.] Scuola Superiore St Anna, Inst Life Sci, Pisa, Italy.
C3 University of Pisa; University of Siena; Consiglio Nazionale delle
   Ricerche (CNR); Istituto di Fisiologia Clinica (IFC-CNR); Scuola
   Superiore Sant'Anna
RP Barsotti, S (corresponding author), Univ Pisa, Reumatol, Via Roma 67, I-56126 Pisa, Italy.
EM simone.barsotti.pisa@gmail.com
RI Gaggini, Melania/C-9379-2017; Talarico, Rosaria/AAB-9004-2019; Saponaro,
   Chiara/HNJ-3570-2023; Gastaldelli, Amalia/H-3319-2014
OI Saponaro, Chiara/0000-0001-7336-7362; Barsotti,
   Simone/0000-0002-4864-4505; BIANCHINI, ELISABETTA/0000-0002-1827-8866;
   Gastaldelli, Amalia/0000-0003-2594-1651
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NR 60
TC 8
Z9 9
U1 0
U2 2
PU CLINICAL & EXPER RHEUMATOLOGY
PI PISA
PA VIA SANTA MARIA 31, 56126 PISA, ITALY
SN 0392-856X
EI 1593-098X
J9 CLIN EXP RHEUMATOL
JI Clin. Exp. Rheumatol.
PD NOV-DEC
PY 2019
VL 37
IS 6
BP 1036
EP 1043
PG 8
WC Rheumatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Rheumatology
GA LL2DX
UT WOS:000531365800019
PM 30943137
DA 2025-06-11
ER

PT J
AU Nagalievska, MR
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   Sybirna, NO
AF Nagalievska, M. R.
   Petryn, T. S.
   Sybirna, N. O.
TI Influence of High-Carbohydrate and High-Lipid Diet on the Enzymatic Link
   of Antioxidant Protection and the Level of Oxidatively Modified Proteins
   and Lipids in Rat Erythrocytes
SO CYTOLOGY AND GENETICS
LA English
DT Article
DE Keywords; metabolic syndrome; erythrocytes; antioxidant system
ID INDUCED INSULIN-RESISTANCE; HIGH-FAT-DIET; METABOLIC SYNDROME; STRESS;
   ENZYMES
AB The influence of a high-lipid and high-carbohydrate diet, as inducers of the development of metabolic syndrome on the prooxidant-antioxidant state of rat erythrocytes have been studied. Oxidative damage of cellular components was evaluated by the content of thiobarbituric acid reactive substances (TBARS) as well as products of oxidative modification of proteins of a neutral and basic nature. The antioxidant potential of erythrocytes was determined by the activity of superoxide dismutase, catalase, and glutathione peroxidase. Manipulations with diets, especially a high-lipid diet in which an additional source of lipids was olive oil and high-carbohydrate diet, involving the consumption of 10% fructose solution by animals, promoted the development of oxidative stress in rats' erythrocytes. It has been shown that a 28-day high-lipid diet was not accompanied by significant variation in TBARS and oxidized protein modification products but was accompanied by significantly reduced catalase and glutathione peroxidase activity in erythrocyte hemolysate. The longer duration of exposure to the high-lipid diet (42 days) was accompanied by an increase in the content of TBARS against the background of reduced superoxide dismutase and catalase activity. When using fructose for 28 days for the induction of metabolic syndrome, no significant changes in the content of products of oxidative modification of lipids and protein were shown. Instead, a longer effect of a high-carbohydrate diet (42 days) is accompanied by an increase in the content of TBARS. The use of fructose for 28 days caused a decrease in the activity of superoxide dismutase, catalase, and glutathione peroxidase. A similar tendency to decreased activity of the studied enzymes was demonstrated when animals consumed fructose for 42 days. The obtained results allowed us to conclude that the assessment of redox balance of erythrocytes in metabolic syndrome is a rational and convenient method of studying the prooxidant-antioxidant state of the body.
C1 [Nagalievska, M. R.; Petryn, T. S.; Sybirna, N. O.] Ivan Franko Natl Univ Lviv, UA-79005 Lvov, Ukraine.
C3 Ministry of Education & Science of Ukraine; Ivan Franko National
   University Lviv
RP Nagalievska, MR (corresponding author), Ivan Franko Natl Univ Lviv, UA-79005 Lvov, Ukraine.
EM mariia.nagalievska@lnu.edu.ua
RI Sybirna, Nataliia/L-1343-2017; Nagalievska, Mariia/K-9922-2017
OI Nagalievska, Mariia/0000-0002-8990-5521; Petryn,
   Tetiana/0000-0002-0376-0713
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NR 37
TC 1
Z9 1
U1 1
U2 5
PU PLEIADES PUBLISHING INC
PI NEW YORK
PA PLEIADES HOUSE, 7 W 54 ST, NEW YORK,  NY, UNITED STATES
SN 0095-4527
EI 1934-9440
J9 CYTOL GENET+
JI Cytol. Genet.
PD JAN
PY 2022
VL 56
IS 1
BP 1
EP 8
DI 10.3103/S009545272201008X
PG 8
WC Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Genetics & Heredity
GA YX6IU
UT WOS:000754205100001
DA 2025-06-11
ER

PT J
AU Brooks, SD
   DeVallance, E
   d'Audiffret, AC
   Frisbee, SJ
   Tabone, LE
   Shrader, CD
   Frisbee, JC
   Chantler, PD
AF Brooks, Steven D.
   DeVallance, Evan
   d'Audiffret, Alexandre C.
   Frisbee, Stephanie J.
   Tabone, Lawrence E.
   Shrader, Carl D.
   Frisbee, Jefferson C.
   Chantler, Paul D.
TI Metabolic syndrome impairs reactivity and wall mechanics of cerebral
   resistance arteries in obese Zucker rats
SO AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
LA English
DT Article
DE metabolic syndrome; cerebrovascular remodeling; arterial stiffness;
   reactive oxygen species
ID MILD COGNITIVE IMPAIRMENT; ENDOTHELIAL FUNCTION; INSULIN-RESISTANCE;
   BLOOD-PRESSURE; MICROVASCULAR RAREFACTION; MYOGENIC ACTIVATION; VASCULAR
   DEMENTIA; OXIDATIVE STRESS; OXIDANT STRESS; FAT INTAKE
AB The metabolic syndrome (MetS) is highly prevalent in the North American population and is associated with increased risk for development of cerebrovascular disease. This study determined the structural and functional changes in the middle cerebral arteries (MCA) during the progression of MetS and the effects of chronic pharmacological interventions on mitigating vascular alterations in obese Zucker rats (OZR), a translationally relevant model of MetS. The reactivity and wall mechanics of ex vivo pressurized MCA from lean Zucker rats (LZR) and OZR were determined at 7-8, 12-13, and 16-17 wk of age under control conditions and following chronic treatment with pharmacological agents targeting specific systemic pathologies. With increasing age, control OZR demonstrated reduced nitric oxide bioavailability, impaired dilator (acetylcholine) reactivity, elevated myogenic properties, structural narrowing, and wall stiffening compared with LZR. Antihypertensive therapy (e.g., captopril or hydralazine) starting at 7-8 wk of age blunted the progression of arterial stiffening compared with OZR controls, while treatments that reduced inflammation and oxidative stress (e.g., atorvastatin, rosiglitazone, and captopril) improved NO bioavailability and vascular reactivity compared with OZR controls and had mixed effects on structural remodeling. These data identify specific functional and structural cerebral adaptations that limit cerebrovascular blood flow in MetS patients, contributing to increased risk of cognitive decline, cerebral hypoperfusion, and ischemic stroke; however, these pathological adaptations could potentially be blunted if treated early in the progression of MetS.
C1 [Brooks, Steven D.; Frisbee, Jefferson C.] W Virginia Univ, Hlth Sci Ctr, Dept Physiol & Pharmacol, Morgantown, WV 26505 USA.
   [DeVallance, Evan; Chantler, Paul D.] W Virginia Univ, Hlth Sci Ctr, Div Exercise Physiol, Morgantown, WV 26505 USA.
   [d'Audiffret, Alexandre C.; Tabone, Lawrence E.] W Virginia Univ, Hlth Sci Ctr, Dept Surg, Morgantown, WV 26505 USA.
   [Shrader, Carl D.] W Virginia Univ, Hlth Sci Ctr, Dept Family Med, Morgantown, WV 26505 USA.
   [Frisbee, Stephanie J.; Frisbee, Jefferson C.; Chantler, Paul D.] W Virginia Univ, Hlth Sci Ctr, Ctr Basic & Translat Stroke Res, Morgantown, WV 26505 USA.
   [Brooks, Steven D.; DeVallance, Evan; d'Audiffret, Alexandre C.; Frisbee, Stephanie J.; Tabone, Lawrence E.; Shrader, Carl D.; Frisbee, Jefferson C.; Chantler, Paul D.] W Virginia Univ, Hlth Sci Ctr, Ctr Cardiovasc & Resp Sci, Morgantown, WV 26505 USA.
C3 West Virginia University; West Virginia University; West Virginia
   University; West Virginia University; West Virginia University; West
   Virginia University
RP Frisbee, JC (corresponding author), W Virginia Univ, Sch Med, Robert C Byrd Hlth Sci Ctr, Dept Physiol & Pharmacol,Ctr Cardiovasc & Resp Sc, POB 9227, Morgantown, WV 26505 USA.
EM jefrisbee@hsc.wvu.edu
RI Tabone, Lawrence/MGA-2582-2025
OI Frisbee, Jefferson/0000-0003-2751-0599; Frisbee,
   Stephanie/0000-0003-1526-1839
FU American Heart Association [IRG 14330015, PRE 16850005, EIA 0740129N];
   National Institutes of Health [1P20 GM-109098, RR-2865AR, P20
   RR-016477]; National Institute of General Medical Sciences [U54
   GM-104942]
FX This study was supported by American Heart Association Grants IRG
   14330015, PRE 16850005, and EIA 0740129N and National Institutes of
   Health Grants 1P20 GM-109098, RR-2865AR, and P20 RR-016477. This
   research was supported by the National Institute of General Medical
   Sciences Grant U54 GM-104942.
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NR 55
TC 32
Z9 39
U1 0
U2 5
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0363-6135
EI 1522-1539
J9 AM J PHYSIOL-HEART C
JI Am. J. Physiol.-Heart Circul. Physiol.
PD DEC 1
PY 2015
VL 309
IS 11
BP H1846
EP H1859
DI 10.1152/ajpheart.00691.2015
PG 14
WC Cardiac & Cardiovascular Systems; Physiology; Peripheral Vascular
   Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Physiology
GA CX7MR
UT WOS:000365886500005
PM 26475592
OA Green Published
DA 2025-06-11
ER

PT J
AU Gavia-García, G
   Rosado-Pérez, J
   Arista-Ugalde, TL
   Aguiñiga-Sánchez, I
   Santiago-Osorio, E
   Mendoza-Núñez, VM
AF Gavia-Garcia, Graciela
   Rosado-Perez, Juana
   Arista-Ugalde, Taide Laurita
   Aguiniga-Sanchez, Itzen
   Santiago-Osorio, Edelmiro
   Mendoza-Nunez, Victor Manuel
TI The consumption of Sechium edule (chayote) has antioxidant effect
   and prevents telomere attrition in older adults with metabolic syndrome
SO REDOX REPORT
LA English
DT Article
DE Sechium edule; metabolic syndrome; telomeric length; oxidative stress;
   antioxidants; markers inflammatory; telomerase; aging
ID TYPE-2 DIABETES-MELLITUS; OXIDATIVE STRESS; SIGNALING PATHWAY; PROTEIN
   OXIDATION; IN-VITRO; T-CELLS; LENGTH; ACID; QUERCETIN; EXPRESSION
AB Objective To determine the effect of the consumption of Sechium edule (1.5 g/day) for six months on oxidative stress (OxS) and inflammation markers and its association with telomere length (TL) in older adults with metabolic syndrome (MetS). Methods The study was conducted in a sample of 48 older adults: placebo (EP) and experimental (EG) groups. Lipoperoxides, protein carbonylation, 8-OHdG, total oxidant status (TOS), SOD, GPx, H2O2 inhibition, total antioxidant status (TAS), inflammatory cytokines (IL6, IL10, TNF-alpha), and TL were measured before and six months post-treatment. Results We found a significant decrease in the levels of lipoperoxides, protein carbonylation, 8-OHdG, TOS in the EG in comparison PG. Likewise, a significante increase of TAS, IL-6, and IL-10 levels was found at six months post-treatment in EG in comparison with PG. TL showed a statistically significant decrease in PG compared to post-treatment EG. Conclusions Our findigns showed that the supplementation of Sechium edule has antioxidant, and anti-inflammatory effects, and diminushion of shortening of telomeric DNA in older adults with MetS. This would be the first study that shows that the intervention with Sechium edule has a possible geroprotective effect by preventing telomeres from shortening as usually happens in these patients. Therefore, suggesting a protection of telomeric DNA and genomic DNA.
C1 [Gavia-Garcia, Graciela; Rosado-Perez, Juana; Arista-Ugalde, Taide Laurita; Mendoza-Nunez, Victor Manuel] Univ Nacl Autonoma Mexico, Res Unit Gerontol, FES Zaragoza, Mexico City, Mexico.
   [Aguiniga-Sanchez, Itzen; Santiago-Osorio, Edelmiro] Univ Nacl Autonoma Mexico, Res Unit Cell Differentiat & Canc, Hematopoiesis & LeukemiaLab, FES Zaragoza, Mexico City, Mexico.
   [Mendoza-Nunez, Victor Manuel] Univ Nacl Autonoma Mexico, Res Unit Gerontol, FES Zaragoza, Mexico City 09230, Mexico.
C3 Universidad Nacional Autonoma de Mexico; Universidad Nacional Autonoma
   de Mexico; Universidad Nacional Autonoma de Mexico
RP Mendoza-Núñez, VM (corresponding author), Univ Nacl Autonoma Mexico, Res Unit Gerontol, FES Zaragoza, Mexico City 09230, Mexico.
EM mendovic@unam.mx
RI Mendoza-Núñez, Víctor Manuel/AFL-2465-2022
OI Mendoza-Nunez, Victor Manuel/0000-0002-9137-3405
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NR 104
TC 8
Z9 8
U1 4
U2 19
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1351-0002
EI 1743-2928
J9 REDOX REP
JI Redox Rep.
PD DEC 31
PY 2023
VL 28
IS 1
AR 2207323
DI 10.1080/13510002.2023.2207323
PG 13
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA F4WU6
UT WOS:000982377100001
PM 37140004
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Roddy, GW
AF Roddy, Gavin W.
TI Metabolic syndrome and the aging retina
SO CURRENT OPINION IN OPHTHALMOLOGY
LA English
DT Review
DE age-related macular degeneration; aging; glaucoma; inflammaging;
   metabolic syndrome; optic neuropathy; over nutrition; Western diet
ID OPEN-ANGLE GLAUCOMA; HIGH INTRAOCULAR-PRESSURE; NUTRITION EXAMINATION
   SURVEY; KOREAN NATIONAL-HEALTH; MACULAR DEGENERATION; RISK-FACTORS;
   CALORIC RESTRICTION; OCULAR HYPERTENSION; TRANSGENIC MICE; WESTERN DIET
AB Purpose of review This review explores metabolic syndrome (MetS) as a risk factor that accelerates aging in retinal neurons and may contribute to the neurodegeneration seen in glaucomatous optic neuropathy (GON) and age-related macular degeneration (AMD). Recent findings Both animal model experiments and epidemiologic studies suggest that metabolic stress may lead to aberrant regulation of a number of cellular pathways that ultimately lead to premature aging of the cell, including those of a neuronal lineage. GON and AMD are each leading causes of irreversible blindness worldwide. Aging is a significant risk factor in the specific retinal neuron loss that is seen with each condition. Though aging at a cellular level is difficult to define, there are many mechanistic modifiers of aging. Metabolic-related stresses induce inflammation, oxidative stress, mitochondrial dysfunction, endoplasmic reticulum stress, alterations to the unfolded protein response, defects in autophagy, alterations to the microbiome, and deposition of advanced glycation end products that can all hasten the aging process. Due to the number of variables related to metabolic health, defining criteria to enable the study of risk factors at a population level is challenging. MetS is a definable constellation of related metabolic risk factors that includes enlarged waist circumference, dyslipidemia, systemic hypertension, and hyperglycemia. MetS has been associated with both GON and AMD and may contribute to disease onset and/or progression in each disease.
C1 [Roddy, Gavin W.] Mayo Clin, Dept Ophthalmol, 200 First St SW, Rochester, MN 55905 USA.
C3 Mayo Clinic
RP Roddy, GW (corresponding author), Mayo Clin, Dept Ophthalmol, 200 First St SW, Rochester, MN 55905 USA.
EM roddy.gavin@mayo.edu
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NR 127
TC 19
Z9 19
U1 1
U2 9
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1040-8738
EI 1531-7021
J9 CURR OPIN OPHTHALMOL
JI Curr. Opin. Ophthalmol.
PD MAY
PY 2021
VL 32
IS 3
BP 280
EP 287
DI 10.1097/ICU.0000000000000747
PG 8
WC Ophthalmology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Ophthalmology
GA SS7CW
UT WOS:000661913000017
PM 33630786
DA 2025-06-11
ER

PT J
AU Klein, J
   Brauer, P
   Royall, D
   Israeloff-Smith, M
   Klein, D
   Tremblay, A
   Dhaliwal, R
   Rheaume, C
   Mutch, DM
   Jeejeebhoy, K
AF Klein, Jennifer
   Brauer, Paula
   Royall, Dawna
   Israeloff-Smith, Maya
   Klein, Doug
   Tremblay, Angelo
   Dhaliwal, Rupinder
   Rheaume, Caroline
   Mutch, David M.
   Jeejeebhoy, Khursheed
TI Patient experiences of a lifestyle program for metabolic syndrome
   offered in family medicine clinics: a mixed methods study
SO BMC FAMILY PRACTICE
LA English
DT Article
ID HEALTH; INTERVENTION; CHALLENGES; REDUCTION; BARRIERS; EXERCISE;
   BEHAVIOR; ADULTS; RISK
AB Background: Patient perspectives on new programs to manage metabolic syndrome (MetS) are critical to evaluate for possible implementation in the primary healthcare system. Participants' perspectives were sought for the Canadian Health Advanced by Nutrition and Graded Exercise (CHANGE) study, which enrolled 293 participants, and demonstrated 19% reversal of MetS after 1 year. The main purpose of this study was to examine participants' perceptions of their experiences with the CHANGE program, enablers and barriers to change.
   Methods: A convergent parallel mixed methods design combined patients perspectives collected by questionnaires (n = 164), with insights from focus groups (n = 41) from three sites across Canada. Qualitative data were thematically analyzed using interpretative description. Insights were organized within a socio-ecologic framework.
   Results: Key aspects identified by participants included intra-individual factors (personal agency, increased time availability), inter-individual factors (trust, social aspects) and organizational factors (increased mental health support, tailored programs).
   Conclusion: Results revealed participants' overall support for the CHANGE program, especially the importance of an extended program under the guidance of a family physician along with a skilled and supportive team. Team delivery of a lifestyle program in primary care or family medicine clinics is a complex intervention and use of a mixed methods design was helpful for exploring patient experiences and key issues on enablers and barriers to health behavior change.
C1 [Klein, Jennifer] Glenrose Rehabil Hosp, Edmonton, AB, Canada.
   [Brauer, Paula; Royall, Dawna; Israeloff-Smith, Maya] Univ Guelph, Dept Family Relat & Appl Nutr, Guelph, ON, Canada.
   [Klein, Doug] Univ Alberta, Dept Family Med, Edmonton, AB, Canada.
   [Tremblay, Angelo] Laval Univ, Dept Kinesiol, Quebec City, PQ, Canada.
   [Dhaliwal, Rupinder] Metab Syndrome Canada, Kingston, ON, Canada.
   [Rheaume, Caroline] Laval Univ, Dept Family Med & Emergency Med, Quebec City, PQ, Canada.
   [Mutch, David M.] Univ Guelph, Dept Human Hlth & Nutr Sci, Guelph, ON, Canada.
   [Jeejeebhoy, Khursheed] Univ Toronto, Dept Med, Toronto, ON, Canada.
C3 University of Guelph; University of Alberta; Laval University; Laval
   University; University of Guelph; University of Toronto
RP Klein, D (corresponding author), Univ Alberta, Dept Family Med, Edmonton, AB, Canada.
EM douglask@ualberta.ca
RI ; Rheaume, Caroline/GLS-9147-2022
OI Tremblay, Angelo/0000-0002-0824-0530; Rheaume,
   Caroline/0000-0002-1863-4410; Dhaliwal, Rupinder/0000-0001-7320-9487
FU Metabolic Syndrome Canada
FX Metabolic Syndrome Canada is a not-for-profit charitable organization
   that funded the current study.
CR Anderson G., 2010, Chronic Care
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NR 37
TC 6
Z9 6
U1 0
U2 5
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2296
J9 BMC FAM PRACT
JI BMC Fam. Pract.
PD AUG 31
PY 2018
VL 19
AR 148
DI 10.1186/s12875-018-0837-z
PG 10
WC Primary Health Care; Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA GS3IS
UT WOS:000443489900001
PM 30170544
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Stiles-Shields, C
   Bogue, C
   Le Grange, D
   Yohanna, D
AF Stiles-Shields, Colleen
   Bogue, Cynthia
   Le Grange, Daniel
   Yohanna, Daniel
TI An Examination of Adults on Antipsychotic Medication at Risk for
   Metabolic Syndrome: A Comparison with Obese and Eating Disorder
   Populations
SO EUROPEAN EATING DISORDERS REVIEW
LA English
DT Article
DE antipsychotic medication; metabolic syndrome; obesity; binge eating
ID BECK DEPRESSION INVENTORY; EXAMINATION-QUESTIONNAIRE; ATYPICAL
   ANTIPSYCHOTICS; PSYCHOMETRIC PROPERTIES; ANOREXIA-NERVOSA; ADOLESCENTS;
   PSYCHOPATHOLOGY; RELIABILITY; MANAGEMENT; WOMEN
AB Little research has explored how eating disorders (ED) may be involved in the increased risk for metabolic syndrome in adults on antipsychotic medication. This pilot study compared participants on antipsychotic medication with obese and ED samples with respect to demographic and psychosocial factors. Participants (antipsychotic medication n=12; obese n=12; ED n=12), were adults presenting to an outpatient psychiatry department (83.3% women; M age=45.75 +/- 11.5). Analysis of variance, analysis of covariance and chi-square tests were used to compare the samples. Participants on antipsychotic medications had a significantly lower mean body mass index than the obese (p<.001) and ED (p<.05) samples, as well as significantly lower Restraint Total scores (p<.05) and subjective binge episode frequency (p<.05) than the ED sample. The lack of significant differences that occurred between the antipsychotic medication sample and two eating disorder samples significantly different from one another indicates that this population may have unique symptomology and treatment needs. Copyright (c) 2012 John Wiley & Sons, Ltd and Eating Disorders Association.
C1 [Stiles-Shields, Colleen; Bogue, Cynthia; Le Grange, Daniel; Yohanna, Daniel] Univ Chicago, Dept Psychiat & Behav Neurosci, Chicago, IL 60637 USA.
C3 University of Chicago
RP Stiles-Shields, C (corresponding author), Univ Chicago, Dept Psychiat & Behav Neurosci, 5841 S Maryland Ave,MC 3077, Chicago, IL 60637 USA.
EM cshields@yoda.bsd.uchicago.edu
RI Le Grange, Daniel/A-2649-2011
OI Stiles-Shields, Colleen/0000-0002-6759-8380
CR Amer Diabet Assoc, 2004, DIABETES CARE, V27, P596, DOI 10.2337/diacare.27.2.596
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NR 31
TC 2
Z9 2
U1 0
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1072-4133
EI 1099-0968
J9 EUR EAT DISORD REV
JI Eur. Eat. Disord. Rev.
PD MAR
PY 2013
VL 21
IS 2
BP 165
EP 169
DI 10.1002/erv.2200
PG 5
WC Psychology, Clinical; Psychiatry
WE Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA 087GJ
UT WOS:000314749000011
PM 22936616
OA Green Published
DA 2025-06-11
ER

PT J
AU Ströher, RLM
   Sartori, MGF
   Takano, CC
   de Araújo, MP
   Girao, MJBC
AF Menegaz Stroher, Rejane Lis
   Ferreira Sartori, Marair Gracio
   Takano, Claudia Cristina
   de Araujo, Maita Poli
   Batista Castelo Girao, Manoel Joao
TI Metabolic syndrome in women with and without stress urinary incontinence
SO INTERNATIONAL UROGYNECOLOGY JOURNAL
LA English
DT Article
DE Metabolic syndrome; Obesity; Stress urinary incontinence
ID PELVIC ORGAN PROLAPSE; RISK-FACTORS; PREVALENCE; OBESITY; INTERVENTION;
   SYMPTOMS; IMPACT; ICIQ
AB Introduction Metabolic syndrome (MS) is a disease of multifactorial etiology characterized by increased waist circumference, elevated triglyceride levels, decreased HDL cholesterol levels, high blood pressure and hyperglycemia. The objective of this study was to compare the frequency of MS in patients with and without stress urinary incontinence (SUI). Methods The components of MS were evaluated in 85 women with SUI seen at the Urogynecology and Vaginal Surgery Sector of the Gynecology Department of Universidade Federal de Sao Paulo (UNIFESP-EPM) and in 108 women without SUI seen at the General Gynecology Clinic of the Gynecology Department of UNIFESP-EPM. Results The MS diagnosis was more prevalent in patients with SUI, with the frequency according to the International Diabetes Federation criteria being 69.4% in the case group with SUI and 38% in the control group, whereas according to the National Cholesterol Education Program Adult Treatment Panel III recommendations, MS was frequent in 64.7% of the cases and 25% of the controls. Each MS component was evaluated, and the body mass index, weight and waist circumference were significantly higher in the case group (with SUI) compared with the control group (p < 0.001). The women in the case group showed an average HDL cholesterol value statistically lower and triglyceride and glycemia values statistically higher than the women in the control group (p < 0.001 and p = 0.005). Conclusion MS frequency was higher in patients with SUI, which shows a possible association between these two conditions.
C1 [Menegaz Stroher, Rejane Lis; Ferreira Sartori, Marair Gracio; Takano, Claudia Cristina; de Araujo, Maita Poli; Batista Castelo Girao, Manoel Joao] Univ Fed Sao Paulo, Sao Paulo, SP, Brazil.
C3 Universidade Federal de Sao Paulo (UNIFESP)
RP Ströher, RLM (corresponding author), Univ Fed Sao Paulo, Sao Paulo, SP, Brazil.
EM rejanemenegaz@yahoo.com.br; marair.sartori@uol.com.br;
   claudia.takano@uol.com.br; dramaita@gmail.com; mjbcg@terra.com.br
RI Girao, Manoel/ABA-6558-2021; Novoa, Claudia/D-5837-2012; Araujo,
   Maita/ABA-5842-2020; Sartori, Marair/D-3888-2012; POLI DE ARAUJO,
   MAITA/E-8248-2015
OI Sartori, Marair/0000-0002-3001-6076; POLI DE ARAUJO,
   MAITA/0000-0003-4717-0106
CR [Anonymous], INT UROGYNECOL J
   [Anonymous], IDF CONS WORLD WID D
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NR 29
TC 34
Z9 35
U1 0
U2 10
PU SPRINGER LONDON LTD
PI LONDON
PA 236 GRAYS INN RD, 6TH FLOOR, LONDON WC1X 8HL, ENGLAND
SN 0937-3462
EI 1433-3023
J9 INT UROGYNECOL J
JI Int. Urogynecol. J.
PD JAN
PY 2020
VL 31
IS 1
BP 173
EP 179
DI 10.1007/s00192-019-03880-6
PG 7
WC Obstetrics & Gynecology; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology; Urology & Nephrology
GA KK7AA
UT WOS:000512889400021
PM 30721325
DA 2025-06-11
ER

PT J
AU Heeba, GH
   Rabie, EM
   Abuzeid, MM
   Bekhit, AA
   Khalifa, MM
AF Heeba, Gehan Hussein
   Rabie, Esraa Mohamed
   Abuzeid, Mekky Mohamed
   Bekhit, Amany Abdelrehim
   Khalifa, Mohamed Montaser
TI Morin alleviates fructose-induced metabolic syndrome in rats via
   ameliorating oxidative stress, inflammatory and fibrotic markers
SO KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY
LA English
DT Article
DE Flavonoids; Fructose; Insulin resistance; Liver; Metabolic syndrome
AB Metabolic syndrome (MBS) is a widespread disease that has strongly related to unhealthy diet and low physical activity, which initiate more serious conditions such as obesity, cardiovascular diseases and type 2 diabetes mellitus. This study aimed to examine the therapeutic effects of morin, as one of the flavonoids constituents, which widely exists in many herbs and fruits, against some metabolic and hepatic manifestations observed in MBS rats and the feasible related mechanisms. MBS was induced in rats by high fructose diet feeding for 12 weeks. Morin (30 mg/kg) was administered orally to both normal and MBS rats for 4 weeks. Liver tissues were used for determination of liver index, hepatic expression of glucose transporter 2 (GLUT2) as well as both inflammatory and fibrotic markers. The fat/ muscle ratio, metabolic parameters, systolic blood pressure, and oxidative stress markers were also determined. Our data confirmed that the administration of morin in fructose diet rats significantly reduced the elevated systolic blood pressure. The altered levels of metabolic parameters such as blood glucose, serum insulin, serum lipid profile, and oxidative stress markers were also reversed approximately to the normal values. In addition, morin treatment decreased liver index, serum liver enzyme activities, and fat/muscle ratio. Furthermore, morin relatively up-regulated GLUT2 expression, however, down-regulated NF-kappa B, TNF-alpha, and TGF-beta expressions in the hepatic tissues. Here, we revealed that morin has an exquisite effect against metabolic disorders in the experimental model through, at least in part, antioxidant, anti-inflammatory, and anti-fibrotic mechanisms.
C1 [Heeba, Gehan Hussein; Rabie, Esraa Mohamed; Khalifa, Mohamed Montaser] Menia Univ, Dept Pharmacol, El Minia 61111, Egypt.
   [Abuzeid, Mekky Mohamed; Bekhit, Amany Abdelrehim] Menia Univ, Fac Pharm, Biochem, El Minia 61111, Egypt.
C3 Egyptian Knowledge Bank (EKB); Minia University; Egyptian Knowledge Bank
   (EKB); Minia University
RP Bekhit, AA (corresponding author), Menia Univ, Fac Pharm, Biochem, El Minia 61111, Egypt.
EM umkareem05@yahoo.com
RI Heeba, Gehan/H-7245-2019
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NR 59
TC 9
Z9 9
U1 0
U2 7
PU KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY
PI SEOUL
PA C/O EDITORIAL OFFICE, 448-13 SEOKYO-DONG, SEOUL, SOUTH KOREA
SN 1226-4512
EI 2093-3827
J9 KOREAN J PHYSIOL PHA
JI KOREAN J. PHYSIOL. PHARMACOL.
PD MAY
PY 2021
VL 25
IS 3
BP 177
EP 187
DI 10.4196/kjpp.2021.25.3.177
PG 11
WC Pharmacology & Pharmacy; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Physiology
GA RO6IG
UT WOS:000641146000001
PM 33859058
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Atik, L
   Erdogan, A
   Karaahmet, E
   Saracli, O
   Atasoy, N
   Kurcer, MA
   Balcioglu, I
AF Atik, Levent
   Erdogan, Ayten
   Karaahmet, Elif
   Saracli, Ozge
   Atasoy, Nuray
   Kurcer, Mehmet Ali
   Balcioglu, Ibrahim
TI Antipsychotic prescriptions in a university hospital outpatient
   population in Turkey: A retrospective database analysis, 2005-2006
SO PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
LA English
DT Review
DE atypical antipsychotics; guidelines; prescribing; Turkey; typical
   antipsychotics
ID OBSESSIVE-COMPULSIVE DISORDER; CROSS-SECTIONAL SURVEY; PSYCHOTROPIC-DRUG
   USE; ATYPICAL ANTIPSYCHOTICS; QUETIAPINE AUGMENTATION; CEREBROVASCULAR
   EVENTS; GENERAL-PRACTITIONERS; PRESCRIBING PRACTICES; METABOLIC
   SYNDROME; UNITED-STATES
AB Objective: The aim of this study is to document the sociodemographic and the clinical profile of patients who are on antipsychotic (AP) medication prescribed in outpatient mental health clinic of a university hospital.
   Methods: A retrospective chart review was conducted for all outpatient files between 2005 and 2006 at the Zonguldak Karaelmas University, Medical Faculty Hospital, Department of Psychiatry in Turkey. All patients prescribed AP with regular follow up were recruited for the study. The type of AP and the route of administration were recorded. The diagnosis, age and gender of the patients were also evaluated.
   Results: We reviewed 1606 patients' files. APs were prescribed in 27.6% of the patients. Atypical antipsychotics (AAPs) represented 75.1% and typical antipsychotics (TAPs) represented 24.9% of all antipsychotic prescriptions in our study. The main psychiatric diagnoses associated with a TAP prescription were: psychotic disorders (6.5%), major affective disorders (49.5%), anxiety disorders (36.4%), and other psychiatric diseases (7.4%). The main psychiatric diagnoses associated with an AAP prescription were: psychotic disorders (35.1%), major affective disorders (31.1%), anxiety disorders (27.8%), somatoform disorders (2.4%) and other psychiatric diseases (6.4%). Twenty-eight of these patients (6.3%) were prescribed more than one AP, 45 patients were prescribed mood stabilizer (10.2%) and 272 patients were prescribed antidepressant agents (61.2%) in addition to AP.
   Conclusions: The results reflect the particular use of AAPs in present study population. In line with the published data, the results of this study show that AAPs and TAPs are widely used in those with major affective disorders and psychotic disorders. These findings also underline the widespread off-label use of APs in the treatment of other psychiatric disorders. (C) 2008 Elsevier Inc. All rights reserved.
C1 [Atik, Levent; Karaahmet, Elif; Atasoy, Nuray] Zonguldak Karaelmas Univ, Fac Med, Dept Psychiat, TR-67600 Kozlu, Zonguldak, Turkey.
   [Erdogan, Ayten] Zonguldak Karaelmas Univ, Fac Med, Dept Child & Adolescent Psychiat, Zonguldak, Turkey.
   [Saracli, Ozge] State Hosp Burdur, Dept Psychiat, Ankara, Turkey.
   [Kurcer, Mehmet Ali] Zonguldak Karaelmas Univ, Fac Med, Dept Publ Hlth, Zonguldak, Turkey.
   [Balcioglu, Ibrahim] Istanbul Univ, Cerrahpasa Fac Med, Dept Psychiat, Istanbul, Turkey.
C3 Zonguldak Bulent Ecevit University; Zonguldak Bulent Ecevit University;
   Burdur State Hospital; Zonguldak Bulent Ecevit University; Istanbul
   University - Cerrahpasa; Istanbul University
RP Atik, L (corresponding author), Zonguldak Karaelmas Univ, Fac Med, Dept Psychiat, TR-67600 Kozlu, Zonguldak, Turkey.
EM leventatik2003@yahoo.com
RI Karaahmet, Elif/AAG-1157-2021
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NR 57
TC 5
Z9 5
U1 2
U2 3
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0278-5846
EI 1878-4216
J9 PROG NEURO-PSYCHOPH
JI Prog. Neuro-Psychopharmacol. Biol. Psychiatry
PD MAY 15
PY 2008
VL 32
IS 4
BP 968
EP 974
DI 10.1016/j.pnpbp.2007.12.031
PG 7
WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA 310ZU
UT WOS:000256570400008
PM 18243462
DA 2025-06-11
ER

PT J
AU Hsu, YC
   Hsu, CC
   Chang, KH
   Lee, CY
   Chong, LW
   Wang, YC
   Kao, CH
AF Hsu, Yi-Chao
   Hsu, Chih-Chao
   Chang, Kuang-Hsi
   Lee, Chang-Yin
   Chong, Lee-Won
   Wang, Yu-Chiao
   Kao, Chia-Hung
TI Increased Subsequent Risk of Peptic Ulcer Diseases in Patients With
   Bipolar Disorders
SO MEDICINE
LA English
DT Article
ID HELICOBACTER-PYLORI INFECTION; METABOLIC SYNDROME; ANXIETY DISORDERS;
   AXIS; STRESS; BRAIN; SCHIZOPHRENIA; INFLAMMATION; ADULTS; POLYMORPHISMS
AB Previous studies have reported that patients with bipolar disorders (BDs) exhibit increased physical comorbidity and psychological distress. Studies have shown that schizophrenia and anxiety increase the risk of peptic ulcer diseases (PUDs). Therefore, we conducted this study to determine the association between these 2 diseases and examine the possible risk factors.
   We used patients diagnosed with BDs from the Taiwan National Health Insurance Research Database. A comparison cohort comprising patients without BDs was frequency matched by age, sex, and comorbidities, and the occurrence of PUDs was evaluated in both the cohorts.
   The BD and non-BD cohort consisted of 21,060 patients with BDs and 84,240 frequency-matched patients without BDs, respectively. The incidence of PUDs (hazard ratio, 1.51; 95% confidence interval, 1.43-1.59; P < 0.001) was higher among the patients with BDs than the control patients. Cox models showed that irrespective of comorbidities, BDs were an independent risk factor for PUDs.
   Patients with BDs exhibit a substantially higher risk for developing PUDs. According to our data, we suggest that, following a diagnosis of BD, practitioners could notice the occurrence of PUD and associated prevention. Further prospective clinical studies investigating the relationship between BDs and PUDs are warranted.
C1 [Hsu, Chih-Chao] Kaohsiung Vet Gen Hosp, Dept Psychiat, Kaohsiung, Taiwan.
   [Hsu, Yi-Chao] Mackay Med Coll, Inst Biomed Sci, Taipei, Taiwan.
   [Chang, Kuang-Hsi] Taichung Vet Gen Hosp, Dept Med Res, Taichung, Taiwan.
   [Lee, Chang-Yin] I Shou Univ, Sch Chinese Med Post Baccalaureate, Kaohsiung, Taiwan.
   [Chong, Lee-Won] Shin Kong Wu Ho Mem Hosp, Dept Internal Med, Div Gastroenterol & Hepatol, Taipei, Taiwan.
   [Wang, Yu-Chiao] China Med Univ Hosp, Management Off Hlth Data, Taichung, Taiwan.
   [Wang, Yu-Chiao] China Med Univ, Coll Med, Taichung, Taiwan.
   [Kao, Chia-Hung] China Med Univ, Dept Nucl Med, Taichung, Taiwan.
   [Kao, Chia-Hung] China Med Univ, PET Ctr, Taichung, Taiwan.
   [Kao, Chia-Hung] China Med Univ, Coll Med, Grad Inst Clin Med Sci, Taichung, Taiwan.
   [Kao, Chia-Hung] China Med Univ, Coll Med, Sch Med, Taichung, Taiwan.
C3 Kaohsiung Veterans General Hospital; Academia Sinica - Taiwan; Mackay
   Medical College; Taichung Veterans General Hospital; I Shou University;
   Shin Kong Wu Ho Su Memorial Hospital; China Medical University Taiwan;
   China Medical University Hospital - Taiwan; China Medical University
   Taiwan; China Medical University Taiwan; China Medical University
   Taiwan; China Medical University Taiwan; China Medical University Taiwan
RP Hsu, YC (corresponding author), China Med Univ, Grad Inst Clin Med Sci, 2 Yuh Der Rd, Taichung 404, Taiwan.
EM d10040@mail.cmuh.org.tw
RI Wang, Ying-Chiao/U-8210-2017; Hsu, Yi-Chao/AAK-7478-2021
OI Hsu, Yi-Chao/0000-0001-9071-475X
FU Taiwan Ministry of Health and Welfare Clinical Trial and Research Center
   of Excellence [MOHW104-TDU-B-212-113002]; China Medical University
   Hospital, Academia Sinica Taiwan Biobank, Stroke Biosignature Project
   [BM104010092]; NRPB Stroke Clinical Trial Consortium [MOST
   103-2325-B-039-006]; Taiwan Ministry of Science and Technology
   [MOST103-2314-B-715-001-MY2]; Mackay Medical College Project
   [RD1030076]; Tseng-Lien Lin Foundation, Taichung, Taiwan; Taiwan Brain
   Disease Foundation, Taipei, Taiwan; Katsuzo and Kiyo Aoshima Memorial
   Funds, Japan; CMU under the Aim for Top University Plan of the Ministry
   of Education, Taiwan
FX This study is supported in part by the Taiwan Ministry of Health and
   Welfare Clinical Trial and Research Center of Excellence
   (MOHW104-TDU-B-212-113002); China Medical University Hospital, Academia
   Sinica Taiwan Biobank, Stroke Biosignature Project (BM104010092); NRPB
   Stroke Clinical Trial Consortium (MOST 103-2325-B-039-006); Taiwan
   Ministry of Science and Technology (MOST103-2314-B-715-001-MY2); Mackay
   Medical College Project (RD1030076); Tseng-Lien Lin Foundation,
   Taichung, Taiwan; Taiwan Brain Disease Foundation, Taipei, Taiwan;
   Katsuzo and Kiyo Aoshima Memorial Funds, Japan; and CMU under the Aim
   for Top University Plan of the Ministry of Education, Taiwan. The
   funders had no role in study design, data collection and analysis,
   decision to publish, or preparation of the manuscript. No additional
   external funding received for this study.
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NR 46
TC 10
Z9 10
U1 0
U2 8
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD JUL
PY 2015
VL 94
IS 29
AR e1203
DI 10.1097/MD.0000000000001203
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA CP5LS
UT WOS:000359924200001
PM 26200637
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Hayden, MR
AF Hayden, Melvin R.
TI An Immediate and Long-Term Complication of COVID-19 May Be Type 2
   Diabetes Mellitus: The Central Role of β-Cell Dysfunction, Apoptosis and
   Exploration of Possible Mechanisms
SO CELLS
LA English
DT Review
DE ACE2; amylin; beta-cell apoptosis; islet; islet amyloid; fibrosis;
   metabolic syndrome; oxidative stress;
   renin-angiotensin-aldosterone-system; SARS-CoV-2
ID RENIN-ANGIOTENSIN SYSTEM; ISLET AMYLOID POLYPEPTIDE; HIP RAT MODEL;
   OXIDATIVE STRESS; METABOLIC SYNDROME; INFLAMMATION; EXPRESSION;
   PANCREAS; ULTRASTRUCTURE; INHIBITION
AB The novel coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) was declared a pandemic by the WHO on 19 March 2020. This pandemic is associated with markedly elevated blood glucose levels and a remarkable degree of insulin resistance, which suggests pancreatic islet beta-cell dysfunction or apoptosis and insulin's inability to dispose of glucose into cellular tissues. Diabetes is known to be one of the top pre-existing co-morbidities associated with the severity of COVID-19 along with hypertension, cardiocerebrovascular disease, advanced age, male gender, and recently obesity. This review focuses on how COVID-19 may be responsible for the accelerated development of type 2 diabetes mellitus (T2DM) as one of its acute and suspected long-term complications. These observations implicate an active role of metabolic syndrome, systemic and tissue islet renin-angiotensin-aldosterone system, redox stress, inflammation, islet fibrosis, amyloid deposition along with beta-cell dysfunction and apoptosis in those who develop T2DM. Utilizing light and electron microscopy in preclinical rodent models and human islets may help to better understand how COVID-19 accelerates islet and beta-cell injury and remodeling to result in the long-term complications of T2DM.
C1 [Hayden, Melvin R.] Univ Missouri, Sch Med, Diabet & Cardiovasc Dis Ctr, Dept Internal Med, Columbia, MO 65212 USA.
   [Hayden, Melvin R.] Univ Missouri, Sch Med, Diabet & Cardiovasc Dis Ctr, Dept Diabet Endocrinol & Metab, Columbia, MO 65212 USA.
C3 University of Missouri System; University of Missouri Columbia;
   University of Missouri System; University of Missouri Columbia
RP Hayden, MR (corresponding author), Univ Missouri, Sch Med, Diabet & Cardiovasc Dis Ctr, Dept Internal Med, Columbia, MO 65212 USA.; Hayden, MR (corresponding author), Univ Missouri, Sch Med, Diabet & Cardiovasc Dis Ctr, Dept Diabet Endocrinol & Metab, Columbia, MO 65212 USA.
EM mrh29pete@gmail.com
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NR 89
TC 66
Z9 70
U1 1
U2 7
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2073-4409
J9 CELLS-BASEL
JI Cells
PD NOV
PY 2020
VL 9
IS 11
AR 2475
DI 10.3390/cells9112475
PG 23
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA OW2HU
UT WOS:000592715500001
PM 33202960
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Cui, F
   Hu, HF
   Guo, J
   Sun, J
   Shi, M
AF Cui, Fang
   Hu, Hao Fei
   Guo, Jing
   Sun, Jie
   Shi, Min
TI The Effect of Autophagy on Chronic Intermittent Hypobaric Hypoxia
   Ameliorating Liver Damage in Metabolic Syndrome Rats
SO FRONTIERS IN PHYSIOLOGY
LA English
DT Article
DE chronic intermittent hypobaric hypoxia; metabolic syndrome; endoplasmic
   reticulum stress; autophagy; AMPK-mTOR signaling pathway
ID ENDOPLASMIC-RETICULUM STRESS; NONALCOHOLIC STEATOHEPATITIS; FRUCTOSE;
   INJURY; PATHOGENESIS; DYSFUNCTION; MECHANISMS; DISEASE; OBESITY; ER
AB Aim
   Our previous study demonstrated that chronic intermittent hypobaric hypoxia (CIHH) can confer hepatic protection by reducing endoplasmic reticulum stress (ERS) in high-fat-high-fructose induced metabolic syndrome (MS) rats. It is known that there is a functional coupling between autophagy and ERS. This study aimed to investigate the effect of CIHH on autophagy function and adenosine mono-phosphate-activated protein kinase-mammalian target of rapamycin (AMPK alpha-mTOR) signaling pathway in hepatic tissue of MS rats.
   Main Methods
   6-week old male Sprague-Dawley rats were randomly divided into: control (CON), CIHH (treated with hypobaric hypoxia simulating 5000-m altitude for 28 days, 6 h daily), MS (induced by 16-week high fat diet and 10% fructose water feeding), and MS + CIHH groups (exposed to CIHH after 16-week MS model). Food and water intakes, body weight, Lee's index, fat coefficient, systolic arterial pressure, blood biochemicals, and histopathology of liver were measured, the expression of phosphorylated (p)-AMPK, p-mTOR, autophagy-related and ERS-related proteins were assayed in hepatic tissue.
   Key Findings
   The MS rats displayed obesity, hypertension, polydipsia, glucose and lipids metabolism disorders, increased inflammatory cytokine, hepatic tissue morphological and functional damage, and the up-regulated expressions of ERS-related, autophagy-related proteins and p-mTOR, and the down-regulated expression of p-AMPK alpha. All aforementioned abnormalities in MS rats were ameliorated in MS + CIHH rats.
C1 [Cui, Fang] Hebei Med Univ, Dept Electron Microscope Lab Ctr, Shijiazhuang, Hebei, Peoples R China.
   [Hu, Hao Fei; Guo, Jing; Sun, Jie; Shi, Min] Hebei Med Univ, Dept Clin Lab, Hosp 2, Shijiazhuang, Hebei, Peoples R China.
C3 Hebei Medical University; Hebei Medical University
RP Shi, M (corresponding author), Hebei Med Univ, Dept Clin Lab, Hosp 2, Shijiazhuang, Hebei, Peoples R China.
EM sm8344@sina.com
OI Shi, Min/0009-0004-8316-447X
FU Hebei Province Higher Education Science and Technology Research Project
   [QN2019014]
FX This study was supported by the Hebei Province Higher Education Science
   and Technology Research Project (No. QN2019014).
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Z9 20
U1 1
U2 12
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-042X
J9 FRONT PHYSIOL
JI Front. Physiol.
PD JAN 30
PY 2020
VL 11
AR 13
DI 10.3389/fphys.2020.00013
PG 10
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA KM7YL
UT WOS:000514356100001
PM 32082187
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Chandra, PS
   Kommu, JVS
   Rudhran, V
AF Chandra, Prabha S.
   Kommu, John Vijay Sagar
   Rudhran, Vidyendran
TI Schizophrenia in women and children: A selective review of literature
   from developing countries
SO INTERNATIONAL REVIEW OF PSYCHIATRY
LA English
DT Review
ID ADOLESCENT MENTAL-HEALTH; METABOLIC SYNDROME; GENDER-DIFFERENCES; FAMILY
   CAREGIVERS; HIV-INFECTION; HIGH-RISK; PSYCHIATRIC-INPATIENTS;
   PSYCHOTIC-PATIENTS; SEX-DIFFERENCES; ONSET
AB Women and children with psychotic disorders in developing countries may be vulnerable and have considerable social disadvantages. Gender disadvantage has implications for all health outcomes including mental illnesses. In the more relevant gender-related context we discuss several important issues which affect women with schizophrenia, namely stigma, caregiver burden, functional outcome, marriage, victimization and help-seeking. The findings indicate that there are variations in clinical and functional outcomes and age of onset of illness between different regions. Drug side effects, such as metabolic syndrome appear to be quite common, adding to disease burden in women from developing countries. Victimization and coercion may contribute to poor quality of life and health concerns such as STIs and HIV. Stigma among women with schizophrenia appears to play a major role in help-seeking, caregiver burden and issues such as marriage and parenting. Gender-sensitive care and practices are few and not well documented. Research in the area of psychoses in children and adolescents from LAMI countries is sparse and is mainly restricted to a few clinic-based studies. More research is needed on organic and medical factors contributing to childhood psychoses, pathways to care, help-seeking, and impact of early detection and community care.
C1 [Chandra, Prabha S.; Rudhran, Vidyendran] Natl Inst Mental Hlth & Neurosci, Dept Psychiat, Bangalore 560029, Karnataka, India.
   [Kommu, John Vijay Sagar] Natl Inst Mental Hlth & Neurosci, Dept Child & Adolescent Psychiat, Bangalore 560029, Karnataka, India.
C3 National Institute of Mental Health & Neurosciences - India; National
   Institute of Mental Health & Neurosciences - India
RP Chandra, PS (corresponding author), NIMHANS, Dept Psychiat, Bangalore, Karnataka, India.
EM chandra@nimhans.kar.nic.in
RI Kommu, John Vijay Sagar/AAV-8353-2021
OI Kommu, John Vijay Sagar/0000-0001-9044-2344
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NR 143
TC 10
Z9 10
U1 1
U2 40
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0954-0261
EI 1369-1627
J9 INT REV PSYCHIATR
JI Int. Rev. Psych.
PY 2012
VL 24
IS 5
BP 467
EP 482
DI 10.3109/09540261.2012.707118
PG 16
WC Psychiatry
WE Social Science Citation Index (SSCI)
SC Psychiatry
GA 019OW
UT WOS:000309750200010
PM 23057983
DA 2025-06-11
ER

PT J
AU Sharafi, SM
   Mahdavi, M
   Riahi, R
   Kheirollahi, M
   Kelishadi, R
AF Sharafi, Seyedeh Maryam
   Mahdavi, Manijeh
   Riahi, Roya
   Kheirollahi, Majid
   Kelishadi, Roya
TI Meta-Analysis on the Association of C-Reactive Protein Polymorphisms
   with Metabolic Syndrome
SO GLOBAL MEDICAL GENETICS
LA English
DT Review
DE C-reactive protein; single-nucleotide polymorphisms (SNPs); metabolic
   syndrome; meta-analysis
ID GENE; INFLAMMATION; DEPRESSION; DISEASE; RISK
AB Polymorphisms in the C-reactive protein (CRP) genes might have crucial role in the development of metabolic syndrome (MetS). In the current comprehensive meta-analyses, we aim to provide a quantitative assessment of the association between CRP single-nucleotide polymorphisms (SNPs) and the risk of MetS. An electronic search was performed on several databases. After data extraction, random effect model was used to calculate the pooled odds ratio (OR) and 95% confidence intervals (CIs). Four independent studies including case-control, cohort, and cross-sectional methods were analyzed. Our meta-analysis indicated that CRP polymorphisms are not significantly associated with MetS (OR=0.92, 95% CI=0.77-1.10) with significant heterogeneity ( I-2 =55.4%; p -value=0.008). The subgroup analysis revealed that only GG has significant association with MetS (OR=0.32, 95% CI=0.13-0.80, p -value=0.015) without significant heterogeneity ( I-2 =0%, p -value>0.05). In conclusion, this meta-analysis provides strong evidence that only some SNPs of CRP gene are associated with the risk for development of MetS; and this relationship does not exist in different ethnic populations.
C1 [Sharafi, Seyedeh Maryam] Isfahan Univ Med Sci, Res Inst Primordial Prevent Noncommunicable Dis, Environm Res Ctr, Esfahan, Iran.
   [Mahdavi, Manijeh; Kheirollahi, Majid] Isfahan Univ Med Sci, Res Inst Primordial Prevent Noncommunicable Dis, Pediat Inherited Dis Res Ctr, Esfahan, Iran.
   [Riahi, Roya; Kelishadi, Roya] Isfahan Univ Med Sci, Res Inst Primordial Prevent Noncommunicable Dis, Child Growth & Dev Res Ctr, Esfahan, Iran.
   [Kheirollahi, Majid] Isfahan Univ Med Sci, Sch Med, Dept Genet & Mol Biol, Esfahan, Iran.
C3 Isfahan University of Medical Sciences; Isfahan University of Medical
   Sciences; Isfahan University of Medical Sciences; Isfahan University of
   Medical Sciences
RP Mahdavi, M (corresponding author), Isfahan Univ Med Sci, Res Inst Primordial Prevent Noncommunicable Dis, Pediat Inherited Dis Res Ctr, Esfahan, Iran.
EM mahdavi@pharm.mui.ac.ir
RI Kheirollahi, Majid/W-1912-2017; Mahdavi, Manijeh/R-3003-2019; sharafi,
   seyedeh/AIE-2359-2022
OI Mahdavi Mazdeh, Manijeh/0000-0001-7307-4287
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NR 16
TC 4
Z9 5
U1 0
U2 3
PU THIEME MEDICAL PUBL INC
PI NEW YORK
PA 333 SEVENTH AVE, NEW YORK, NY 10001 USA
SN 2699-9404
J9 GLOB MED GENET
JI Glob. Med. Genet.
PD JUN
PY 2020
VL 7
IS 1
BP 8
EP 13
DI 10.1055/s-0040-1710548
PG 6
WC Genetics & Heredity
WE Emerging Sources Citation Index (ESCI)
SC Genetics & Heredity
GA OH3QZ
UT WOS:000582486700003
PM 32879918
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Namazi, G
   Asa, P
   Sarrafzadegan, N
   Pourfarzam, M
AF Namazi, Gholamreza
   Asa, Parastoo
   Sarrafzadegan, Nizal
   Pourfarzam, Morteza
TI Decreased Na<SUP>+</SUP>/K<SUP>+</SUP>-ATPase Activity and Altered
   Susceptibility to Peroxidation and Lipid Composition in the Erythrocytes
   of Metabolic Syndrome Patients with Coronary Artery Disease
SO ANNALS OF NUTRITION AND METABOLISM
LA English
DT Article
DE Coronary artery disease; Metabolic syndrome; Erythrocyte membrane;
   Oxidative stress; Na+/K+-ATPase activity
ID INCREASED OXIDATIVE STRESS; RED-BLOOD-CELLS; MEMBRANE
AB Background: The increased generation of reactive oxygen species that occurs in the case of a metabolic syndrome (MetS) may be responsible for the increased oxidative injury to erythrocyte membranes in coronary artery disease (CAD). Therefore, we studied the effects of MetS on both indexes of oxidative damage and biochemical properties of erythrocyte membranes in CAD patients. Methods: We analyzed the markers of oxidative stress, Na+/K+-ATPase activity, total cholesterol content of erythrocyte membranes (CEM), and fatty acid compositions of the erythrocyte membrane in 82 patients with stable CAD and 39 non-CAD subjects. Results: The CAD patients had higher levels of CEM, membrane lipid peroxidation, erythrocyte superoxide dismutase (SOD) activity, and Na+/K+-ATPase activity compared with non-CAD subjects. The Na+/K+-ATPase activity was correlated negatively with membrane lipid peroxidation, and positively with the CEM. In CAD patients with MetS compared with those without MetS, we found that the membrane lipid peroxidation and CEM were increased, whereas the n-3 fatty acids content, SOD activity, Na+/K+-ATPase activity were decreased. Conclusion: These findings suggest an impairment of erythrocyte membrane biochemical properties in stable CAD patients as a consequence of oxidative injury that may contribute to the development of CAD. In addition, MetS may be related to increased oxidative injury to erythrocyte membranes. (c) 2019 S. Karger AG, Basel
C1 [Namazi, Gholamreza; Asa, Parastoo] Kashan Univ Med Sci, Res Ctr Biochem & Nutr Metab Dis, Kashan, Iran.
   [Sarrafzadegan, Nizal; Pourfarzam, Morteza] Isfahan Univ Med Sci, Cardiovasc Res Inst, Isfahan Cardiovasc Res Ctr, Esfahan, Iran.
C3 Isfahan University of Medical Sciences
RP Namazi, G (corresponding author), Kashan Univ Med Sci, Fac Med, Dept Clin Biochem, Qotb E Ravandi Blvd,POB 8715988141, Kashan, Iran.
EM namazi-gh@kaums.ac.ir
RI Mohammadifard, Noushin/M-2244-2018
FU Isfahan Cardiovascular Research Center and Medical University of Isfahan
FX This research project was financed by grants from Isfahan Cardiovascular
   Research Center and Medical University of Isfahan. The authors would
   like to thank staff of the angiography unit in Isfahan Noor Hospital and
   staff of Isfahan Cardiovascular Research Institute laboratory for their
   kind cooperation. We would also like to thank all the patients who
   participated in this study.
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NR 28
TC 11
Z9 11
U1 0
U2 4
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0250-6807
EI 1421-9697
J9 ANN NUTR METAB
JI Ann. Nutr. Metab.
PY 2019
VL 74
IS 2
BP 140
EP 148
DI 10.1159/000497065
PG 9
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA HO5CG
UT WOS:000460939800006
PM 30731468
DA 2025-06-11
ER

PT J
AU Fabre, B
   Grosman, H
   Mazza, O
   Nolazco, C
   Machulsky, NF
   Mesch, V
   Schreier, L
   Gidron, Y
   Berg, G
AF Fabre, Bibiana
   Grosman, Halina
   Mazza, Osvaldo
   Nolazco, Carlos
   Fernandez Machulsky, Nahuel
   Mesch, Viviana
   Schreier, Laura
   Gidron, Yori
   Berg, Gabriela
TI Relationship between cortisol, life events and metabolic syndrome in men
SO STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS
LA English
DT Article
DE Abdominal obesity; cortisol; HPA axis; life events; metabolic syndrome;
   stress
ID RISK-FACTORS; MYOCARDIAL-INFARCTION; VITAL EXHAUSTION; SERUM CORTISOL;
   YOUNG-ADULTS; STRESS; HYPERTENSION; ASSOCIATION; HEALTH; WOMEN
AB Psychological factors and stressful life events (LE) are considered to play a role in the onset of the metabolic syndrome (MS). We tested the association between LE and cortisol, a marker of chronic stress, with the risk of developing MS and their interaction. From a total number of 2906 men who completed a screening for the early detection of prostate cancer, 149 healthy men (mean +/- SD age, 58.6 +/- 7.7 years) were included in this study. Participants were assessed by the Holmes and Rahe questionnaire about their experience of LE during the previous 1-5 years. MS was diagnosed according to National Cholesterol Education Program-Adult Treatment Panel III (ATP-III) and International Diabetes Federation (IDF) criteria. Serum cortisol was measured at 08: 00-09: 00 h. Participants with MS (IDF criteria) reported significantly more past LE (p = 0.009) and greater summed weight of LE (p = 0.049) than those without MS. Furthermore, LE interacted with cortisol in relation to MS: in men with increased serum cortisol levels (>= 13.7mg/dl), number of LE significantly predicted MS-status (relative risk (RR) = 1.16, p = 0.03), whereas in men with low cortisol, LE were unrelated to MS (p = 0.52). We conclude that LE were significantly more prevalent in men with the MS than without the MS, according to IDF criteria, independent of the effects of age and body mass index, especially in men with increased serum cortisol levels.
C1 [Fabre, Bibiana; Grosman, Halina; Fernandez Machulsky, Nahuel; Mesch, Viviana; Schreier, Laura; Berg, Gabriela] Univ Buenos Aires, Fac Farm & Bioquim, Dept Clin Biochem, INFIBIOC, RA-1113 Buenos Aires, DF, Argentina.
   [Mazza, Osvaldo; Nolazco, Carlos] Univ Buenos Aires, Hosp Clin, Div Urol, Buenos Aires, DF, Argentina.
   [Gidron, Yori] Vrije Univ Brussel, Fac Med & Pharm, Brussels, Belgium.
C3 University of Buenos Aires; University of Buenos Aires; Vrije
   Universiteit Brussel
RP Berg, G (corresponding author), Univ Buenos Aires, Fac Farm & Bioquim, Dept Clin Biochem, INFIBIOC, Junin 956 CABA, RA-1113 Buenos Aires, DF, Argentina.
EM gaberg@ffyb.uba.ar
RI Mazza, Osvaldo/JAO-4089-2023
OI Berg, Gabriela/0000-0002-5787-8960; Fernandez Machulsky,
   Nahuel/0009-0008-2432-0806
FU University of Buenos Aires; (Argentina) UBACYT [01/2103]; Roemmers
   Foundation
FX This study was supported by Research Grants from the University of
   Buenos Aires, (Argentina) UBACYT (01/2103; 2010-2012); and Roemmers
   Foundation 2010-2011.
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NR 42
TC 20
Z9 23
U1 0
U2 23
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1025-3890
EI 1607-8888
J9 STRESS
JI Stress
PD JAN
PY 2013
VL 16
IS 1
BP 16
EP 23
DI 10.3109/10253890.2012.676112
PG 8
WC Behavioral Sciences; Endocrinology & Metabolism; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Behavioral Sciences; Endocrinology & Metabolism; Neurosciences &
   Neurology
GA 052VA
UT WOS:000312225400003
PM 22416877
DA 2025-06-11
ER

PT J
AU Zhao, NS
   Jiao, KY
   Chiu, YH
   Wallace, TC
AF Zhao, Naisi
   Jiao, Keyi
   Chiu, Yu-Hsiang
   Wallace, Taylor C.
TI Pulse Consumption and Health Outcomes: A Scoping Review
SO NUTRIENTS
LA English
DT Review
DE pulse; seeds; plant proteins; Fabaceae; edible grain
ID TYPE-2 DIABETIC-PATIENTS; CARDIOMETABOLIC RISK-FACTORS; SOY LEGUME
   CONSUMPTION; CARDIOVASCULAR-DISEASE; INSULIN-RESISTANCE; BEAN
   CONSUMPTION; BLOOD-PRESSURE; FOOD SECURITY; DIET; OVERWEIGHT
AB Pulses-comprising the dry, edible seeds of leguminous plants-have long been lauded for their culinary flexibility and substantial nutritional advantages. This scoping review aimed to map the evidence on how pulses contribute to overall human health. Four electronic databases were searched for clinical and observational studies in English. We identified 30 articles (3 cross-sectional studies, 1 federated meta-analysis, 8 prospective cohort studies, 1 before-and-after study, and 17 randomized controlled trials) that met our inclusion criteria. Predominant among the pulses studied were lentils, chickpeas, common bean varieties (e.g., pinto, black, navy, red, kidney), black-eyed peas, cowpeas, and split peas. Consumption modalities varied; most studies examined mixed pulses, while five isolated individual types. In intervention studies, pulses were incorporated into diets by allotting a fixed pulse serving on top of a regular diet or by substituting red meat with pulses, offering a comparative analysis of dietary effects. The health outcomes evaluated were multifaceted, ranging from lipid profiles to blood pressure, cardiovascular disease risk and mortality, type 2 diabetes and glycemic control, metabolic syndrome indicators, inflammatory markers, oxidative stress biomarkers, and hormonal profiles. The most frequently assessed study outcomes included changes in low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, systolic blood pressure, diastolic blood pressure, fasting blood sugar, hemoglobin A1c, waist circumference, and C-reactive protein or high-sensitivity C-reactive protein. This review should serve as a call to action for the scientific community to build upon the existing evidence, enriching our understanding of the nutritional and health-promoting attributes of pulses.
C1 [Zhao, Naisi; Jiao, Keyi; Chiu, Yu-Hsiang] Tufts Univ, Sch Med, Publ Hlth & Community Med, Boston, MA 02111 USA.
   [Jiao, Keyi] Shanghai Jiao Tong Univ, Coll Hlth Sci & Technol, Sch Med, Dept Clin Nutr, Shanghai 200025, Peoples R China.
   [Wallace, Taylor C.] Think Hlth Grp LLC, Washington, DC 20001 USA.
   [Wallace, Taylor C.] George Washington Univ, Sch Med & Hlth Sci, Washington, DC 20037 USA.
   [Wallace, Taylor C.] Tufts Univ, Friedman Sch Nutr Sci & Policy, Boston, MA 02111 USA.
C3 Tufts University; Shanghai Jiao Tong University; George Washington
   University; Tufts University
RP Wallace, TC (corresponding author), Think Hlth Grp LLC, Washington, DC 20001 USA.; Wallace, TC (corresponding author), George Washington Univ, Sch Med & Hlth Sci, Washington, DC 20037 USA.; Wallace, TC (corresponding author), Tufts Univ, Friedman Sch Nutr Sci & Policy, Boston, MA 02111 USA.
EM naisi.zhao@tufts.edu; jiaokeyi@sjtu.edu.cn; yu-hsiang.chiu@tufts.edu;
   taylor.wallace@me.com
RI Zhao, Naisi/LXB-2399-2024; Wallace, Taylor/AFV-9122-2022
OI Zhao, Naisi/0000-0002-0517-0709; Wallace, Taylor/0000-0002-9403-2745
FU American Pulse Association
FX The authors would like to thank Christina West for her editorial
   services and thank Yunting Lai and Yixin Wang for their invaluable
   support in abstract screening.
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NR 52
TC 4
Z9 4
U1 3
U2 7
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD MAY
PY 2024
VL 16
IS 10
AR 1435
DI 10.3390/nu16101435
PG 28
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA RY2Z9
UT WOS:001231166600001
PM 38794673
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Takahashi, K
   Takatsu, M
   Hattori, T
   Murase, T
   Ohura, S
   Takeshita, Y
   Watanabe, S
   Murohara, T
   Nagata, K
AF Takahashi, Keiji
   Takatsu, Miwa
   Hattori, Takuya
   Murase, Tamayo
   Ohura, Sae
   Takeshita, Yuuri
   Watanabe, Shogo
   Murohara, Toyoaki
   Nagata, Kohzo
TI PREMATURE CARDIAC SENESCENCE IN
   DahlS.Z-Lepr<SUP>fa</SUP>/Lepr<SUP>fa</SUP> RATS AS A NEW
   ANIMAL MODEL OF METABOLIC SYNDROME
SO NAGOYA JOURNAL OF MEDICAL SCIENCE
LA English
DT Article
DE metabolic syndrome; cardiac remodeling; oxidative stress;
   renin-angiotensin-aldosterone system; cardiac senescence
ID SMOOTH-MUSCLE-CELLS; GROWTH-FACTOR-I; LEUKOCYTE TELOMERE LENGTH;
   HEART-FAILURE; OXIDATIVE STRESS; DIASTOLIC DYSFUNCTION; CELLULAR
   SENESCENCE; DNA-DAMAGE; INSULIN; ACTIVATION
AB Aging is accelerated by metabolic and cardiovascular diseases, and the risk of these diseases increases with age. Obesity is an important risk factor for many age-related diseases and is linked to reduced telomere length in white blood cells. We investigated whether cardiac senescence might be enhanced in DahlS.Z-Lepr(fa)/Lepr(fa) (DS/obese) rats, which we recently established as a new animal model of metabolic syndrome. The heart of DS/obese rats was compared with that of homozygous lean littermates (DahlS.Z-Lepr(+)/Lepr(+), or DS/lean, rats). DS/obese rats manifested hypertension as well as left ventricular hypertrophy, fibrosis, and diastolic dysfunction at 18 weeks of age. Myocardial oxidative stress and inflammation were increased in DS/obese rats compared with DS/lean rats. Telomere length in myocardial cells did not differ between the two rat strains, whereas telomerase activity and expression of the telomerase reverse transcriptase gene were increased in DS/obese rats. Expression of the senescence-associated genes for checkpoint kinase 2 (Chk2), p53, and p21 as well as that of genes related to the renin-angiotensin-aldosterone system were also up-regulated in the DS/obese rat heart. Our results indicate that DS/obese rats undergo premature cardiac senescence as well as cardiac remodeling in association with the development of diastolic dysfunction in these animals.
C1 [Takahashi, Keiji; Takatsu, Miwa; Hattori, Takuya; Murase, Tamayo; Ohura, Sae; Takeshita, Yuuri; Watanabe, Shogo; Nagata, Kohzo] Nagoya Univ, Grad Sch Med, Dept Pathophysiol Lab Sci, Nagoya, Aichi 4618673, Japan.
   [Murohara, Toyoaki] Nagoya Univ, Grad Sch Med, Dept Cardiol, Nagoya, Aichi 4618673, Japan.
C3 Nagoya University; Nagoya University
RP Nagata, K (corresponding author), Nagoya Univ, Grad Sch Med, Dept Pathophysiol Lab Sci, Higashi Ku, 1-1-20 Daikominami, Nagoya, Aichi 4618673, Japan.
EM nagata@met.nagoya-u.ac.jp
RI Murohara, Toyoaki/M-4958-2014
FU Nippon Boehringer Ingelheim Co. Ltd. (Tokyo, Japan); Kyowa Hakko Kirin
   Co. Ltd. (Tokyo, Japan); Japanese government
FX This work was supported by unrestricted research grants from Nippon
   Boehringer Ingelheim Co. Ltd. (Tokyo, Japan) and Kyowa Hakko Kirin Co.
   Ltd. (Tokyo, Japan), as well as by Management Expenses Grants from the
   Japanese government to Nagoya University.
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NR 43
TC 14
Z9 14
U1 0
U2 1
PU NAGOYA UNIV, SCH MED
PI NAGOYA
PA EDITORIAL OFF, NAGOYA UNIV MED LIB, SCH MED, 65 TSURUMAI-CHO SHOWA- KU,
   NAGOYA, 466-8550, JAPAN
SN 2186-3326
EI 0027-7622
J9 NAGOYA J MED SCI
JI Nagoya J. Med. Sci.
PD FEB
PY 2014
VL 76
IS 1-2
BP 35
EP 49
PG 15
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA AB8DI
UT WOS:000332019900005
PM 25129990
DA 2025-06-11
ER

PT J
AU Rius-Pérez, S
   Torres-Cuevas, I
   Millán, I
   Ortega, AL
   Pérez, S
AF Rius-Perez, Sergio
   Torres-Cuevas, Isabel
   Millan, Ivan
   Ortega, Angel L.
   Perez, Salvador
TI PGC-1α, Inflammation, and Oxidative Stress: An Integrative View
   in Metabolism
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Review
ID PROLIFERATOR-ACTIVATED RECEPTOR; GAMMA COACTIVATOR 1-ALPHA; NF-KAPPA-B;
   FATTY-ACID OXIDATION; MITOCHONDRIAL BIOGENESIS; SKELETAL-MUSCLE;
   TRANSCRIPTIONAL COACTIVATOR; INSULIN-RESISTANCE; PROTEIN-KINASE; PGC-1
   COACTIVATORS
AB Peroxisome proliferator-activated receptor-gamma coactivator (PGC)-1 alpha is a transcriptional coactivator described as a master regulator of mitochondrial biogenesis and function, including oxidative phosphorylation and reactive oxygen species detoxification. PGC-1 alpha is highly expressed in tissues with high energy demands, and it is clearly associated with the pathogenesis of metabolic syndrome and its principal complications including obesity, type 2 diabetes mellitus, cardiovascular disease, and hepatic steatosis. We herein review the molecular pathways regulated by PGC-1 alpha, which connect oxidative stress and mitochondrial metabolism with inflammatory response and metabolic syndrome. PGC-1 alpha regulates the expression of mitochondrial antioxidant genes, including manganese superoxide dismutase, catalase, peroxiredoxin 3 and 5, uncoupling protein 2, thioredoxin 2, and thioredoxin reductase and thus prevents oxidative injury and mitochondrial dysfunction. Dysregulation of PGC-1 alpha alters redox homeostasis in cells and exacerbates inflammatory response, which is commonly accompanied by metabolic disturbances. During inflammation, low levels of PGC-1 alpha downregulate mitochondrial antioxidant gene expression, induce oxidative stress, and promote nuclear factor kappa B activation. In metabolic syndrome, which is characterized by a chronic low grade of inflammation, PGC-1 alpha dysregulation modifies the metabolic properties of tissues by altering mitochondrial function and promoting reactive oxygen species accumulation. In conclusion, PGC-1 alpha acts as an essential node connecting metabolic regulation, redox control, and inflammatory pathways, and it is an interesting therapeutic target that may have significant benefits for a number of metabolic diseases.
C1 [Rius-Perez, Sergio; Ortega, Angel L.; Perez, Salvador] Univ Valencia, Dept Physiol, Fac Pharm, E-46100 Valencia, Spain.
   [Torres-Cuevas, Isabel; Millan, Ivan] Hlth Res Inst La Fe, Neonatal Res Grp, Valencia 46026, Spain.
C3 University of Valencia; Hospital Universitari i Politecnic La Fe;
   Instituto de Investigacion Sanitaria La Fe (IIS La Fe)
RP Pérez, S (corresponding author), Univ Valencia, Dept Physiol, Fac Pharm, E-46100 Valencia, Spain.
RI Ortega, Angel/A-4113-2014; Torres-Cuevas, Isabel/T-8140-2017; Pérez,
   Salvador/N-5943-2014; PEREZ, SERGIO/T-7766-2017; Millán,
   Iván/AAW-9900-2021
OI Millan, Ivan/0000-0003-2049-5875
FU Generalitat Valenciana, Conselleria d'Educacio, Investigacio, Cultura I
   Esport [GV/2019/153]
FX This work was supported by Grant GV/2019/153 from Generalitat
   Valenciana, Conselleria d'Educacio, Investigacio, Cultura I Esport.
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NR 233
TC 486
Z9 517
U1 13
U2 124
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PD MAR 9
PY 2020
VL 2020
AR 1452696
DI 10.1155/2020/1452696
PG 20
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA KY0NP
UT WOS:000522271400005
PM 32215168
OA Green Published, hybrid
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Pahwa, R
   Adams-Huet, B
   Jialal, I
AF Pahwa, Roma
   Adams-Huet, Beverley
   Jialal, Ishwarlal
TI The effect of increasing body mass index on cardio-metabolic risk and
   biomarkers of oxidative stress and inflammation in nascent metabolic
   syndrome
SO JOURNAL OF DIABETES AND ITS COMPLICATIONS
LA English
DT Article
DE Obesity; Inflammation; Waist circumference; Body mass index; Metabolic
   Syndrome
ID INSULIN-RESISTANCE; OBESITY; DYSLIPIDEMIA
AB The effect of BMI defined obesity on cardio-metabolic features and biomarkers of oxidative stress and inflammation in patients with nascent metabolic Syndrome (MetS) is poorly defined. Hence the aim of this study was to examine the effect of increasing obesity on the cardio metabolic risk profile, pro-oxidant state and pro-inflammatory features in nascent MetS patients without Diabetes or CVD. MetS was diagnosed by ATPIII criteria using waist circumference (WC) as the measure of adiposity. Patients (n = 58) were stratified into overweight, obese and extreme obesity groups using BMI cut offs of 25-29.9, 30-39.9 kg/m(2) and >= 40 kg/m(2) and cardio-metabolic features, circulating and cellular biomarkers of oxidative stress and inflammation were determined and correlated with BMI. None of the main cardio-metabolic features including blood pressure, blood glucose, HDL-cholesterol, triglycerides, HOMA-IR, free fatty adds were increased with increasing BMI. Also none of the biomarkers of oxidative stress (ox-LDL, nitrotyrosine and monocyte superoxide anion release) were increased with increasing BMI. However, significant increase in hsCRP, the soluble TNFR1 and sTNFR2 and leptin, were observed with increasing adiposity. Other inflammatory bio-mediators (IL -1 beta, IL-6, IL-8, MCP-1, Toll-like receptors 2-4), endotoxin, LBP, sCD14 and HMGB1, adiponectin, and chemerin did not show significant increases with increasing BMI. Leptin, hsCRP, sTNFR1, and sTNFR2 correlated significantly with BMI. In conclusion, capturing the cardio-metabolic cluster of MetS that predisposed to both increased risk of diabetes and CVD, using waist circumference, as one of the 5 diagnostic criteria is sufficient and BMI does not appear to afford any major incremental benefit on the cardio-metabolic risk factors, increased oxidative stress and the majority of both cellular and circulating biomarkers of inflammation. (C) 2017 Elsevier Inc. All rights reserved.
C1 [Pahwa, Roma; Jialal, Ishwarlal] Calif North State Univ, Coll Med, Sacramento, CA USA.
   [Adams-Huet, Beverley] Univ Texas Southwestern Med Ctr Dallas, Div Biostat, Dallas, TX 75390 USA.
C3 University of Texas System; University of Texas Southwestern Medical
   Center Dallas
RP Jialal, I (corresponding author), Calif North State Univ, Coll Med, Physiol Metab & Pathol, 9700 West Taron Dr, Elk Grove, CA 95757 USA.
EM ishwarlal.jialal@cnsu.edu
RI Jialal, Ishwarlal/AAG-6218-2019
OI Pahwa, Roma/0009-0006-0745-3581
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NR 22
TC 22
Z9 23
U1 1
U2 11
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1056-8727
EI 1873-460X
J9 J DIABETES COMPLICAT
JI J. Diabetes Complications
PD MAY
PY 2017
VL 31
IS 5
BP 810
EP 813
DI 10.1016/j.jdiacomp.2017.02.010
PG 4
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA EV3UC
UT WOS:000401683600006
PM 28285929
DA 2025-06-11
ER

PT J
AU Bekendam, MT
   Vermeltfoort, IAC
   Kop, WJ
   Widdershoven, JW
   Mommersteeg, PMC
AF Bekendam, Maria T.
   Vermeltfoort, Ilse A. C.
   Kop, Willem J.
   Widdershoven, Jos W.
   Mommersteeg, Paula M. C.
TI Psychological factors of suspect coronary microvascular dysfunction in
   patients undergoing SPECT imaging
SO JOURNAL OF NUCLEAR CARDIOLOGY
LA English
DT Article
DE Cardiac stress testing; Emotions; Myocardial ischemia; Psychological
   factors; Suspect CMD
ID INDUCED MYOCARDIAL-ISCHEMIA; CARDIAC SYNDROME-X; CHEST-PAIN;
   ARTERY-DISEASE; HEART-DISEASE; RISK-FACTOR; ANXIETY; STRESS; SYMPTOMS;
   WOMEN
AB Background Patients with myocardial ischemia in the absence of obstructive coronary artery disease (CAD) often experience anginal complaints and are at risk of cardiac events. Stress-related psychological factors and acute negative emotions might play a role in these patients with suspect coronary microvascular dysfunction (CMD). Methods and Results 295 Patients (66.9 +/- 8.7 years, 46% women) undergoing myocardial perfusion single-photon-emission computed tomography (MPI-SPECT), were divided as follows: (1) a non-ischemic reference group (n = 136); (2) patients without inducible ischemia, but with a history of CAD (n = 62); (3) ischemia and documented CAD (n = 52); and (4) ischemia and suspect CMD (n = 45). These four groups were compared with regard to psychological factors and acute emotions. Results revealed no differences between the groups in psychological factors (allP > .646, all effect sizes d < .015). State sadness was higher for patients with suspect CMD (16%) versus the other groups (P = .029). The groups did not differ in the association of psychological factors or emotions with anginal complaints (allPvalues > .448). Conclusion Suspect CMD was not associated with more negative psychological factors compared to other groups. State sadness was significantly higher for patients with suspect CMD, whereas no differences in state anxiety and other psychological factors were found.
C1 [Bekendam, Maria T.; Kop, Willem J.; Widdershoven, Jos W.; Mommersteeg, Paula M. C.] Tilburg Univ, Ctr Res Psychol Somat Dis CoRPS, Dept Med & Clin Psychol, Warandelaan 2, NL-5000 LE Tilburg, Netherlands.
   [Vermeltfoort, Ilse A. C.] Inst Verbeeten, Dept Nucl Med, Tilburg, Netherlands.
   [Widdershoven, Jos W.] Elizabeth TweeSteden Hosp, Dept Cardiol, Tilburg, Netherlands.
C3 Tilburg University; Instituut Verbeeten; Elisabeth-TweeSteden Ziekenhuis
   (ETZ)
RP Bekendam, MT (corresponding author), Tilburg Univ, Ctr Res Psychol Somat Dis CoRPS, Dept Med & Clin Psychol, Warandelaan 2, NL-5000 LE Tilburg, Netherlands.
EM M.T.Bekendam@tilburguniversisy.edu
RI Mommersteeg, Paula/AAB-7801-2019
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NR 50
TC 8
Z9 8
U1 0
U2 4
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1071-3581
EI 1532-6551
J9 J NUCL CARDIOL
JI J. Nucl. Cardiol.
PD APR
PY 2022
VL 29
IS 2
BP 768
EP 778
DI 10.1007/s12350-020-02360-5
EA OCT 2020
PG 11
WC Cardiac & Cardiovascular Systems; Radiology, Nuclear Medicine & Medical
   Imaging
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Cardiovascular System & Cardiology; Radiology, Nuclear Medicine &
   Medical Imaging
GA 0L4PK
UT WOS:000575698300002
PM 33025473
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Ren, J
   Pulakat, L
   Whaley-Connell, A
   Sowers, JR
AF Ren, Jun
   Pulakat, Lakshmi
   Whaley-Connell, Adam
   Sowers, James R.
TI Mitochondrial biogenesis in the metabolic syndrome and cardiovascular
   disease
SO JOURNAL OF MOLECULAR MEDICINE-JMM
LA English
DT Review
DE Metabolic impairment; Oxidative phosphorylation; Mitochondrial
   biogenesis
ID ACTIVATED PROTEIN-KINASE; ANGIOTENSIN-ALDOSTERONE SYSTEM; INDUCED
   CARDIAC CONTRACTILE; DIABETIC CARDIOMYOPATHY; INSULIN-RESISTANCE;
   OXIDATIVE STRESS; SKELETAL-MUSCLE; VENTRICULAR MYOCYTES; NADPH OXIDASE;
   I INHIBITION
AB The metabolic syndrome is a constellation of metabolic disorders including obesity, hypertension, and insulin resistance, components which are risk factors for the development of diabetes, hypertension, cardiovascular, and renal disease. Pathophysiological abnormalities that contribute to the development of the metabolic syndrome include impaired mitochondrial oxidative phosphorylation and mitochondrial biogenesis, dampened insulin metabolic signaling, endothelial dysfunction, and associated myocardial functional abnormalities. Recent evidence suggests that impaired myocardial mitochondrial biogenesis, fatty acid metabolism, and antioxidant defense mechanisms lead to diminished cardiac substrate flexibility, decreased cardiac energetic efficiency, and diastolic dysfunction. In addition, enhanced activation of the renin-angiotensin-aldosterone system and associated increases in oxidative stress can lead to mitochondrial apoptosis and degradation, altered bioenergetics, and accumulation of lipids in the heart. In addition to impairments in metabolic signaling and oxidative stress, genetic and environmental factors, aging, and hyperglycemia all contribute to reduced mitochondrial biogenesis and mitochondrial dysfunction. These mitochondrial abnormalities can predispose a metabolic cardiomyopathy characterized by diastolic dysfunction. Mitochondrial dysfunction and resulting lipid accumulation in skeletal muscle, liver, and pancreas also impede insulin metabolic signaling and glucose metabolism, ultimately leading to a further increase in mitochondrial dysfunction. Interventions to improve mitochondrial function have been shown to correct insulin metabolic signaling and other metabolic and cardiovascular abnormalities. This review explores mechanisms of mitochondrial dysfunction with a focus on impaired oxidative phosphorylation and mitochondrial biogenesis in the pathophysiology of metabolic heart disease.
C1 [Ren, Jun] Univ Wyoming, Ctr Cardiovasc Res & Alternat Med, Coll Hlth Sci, Laramie, WY 82071 USA.
   [Pulakat, Lakshmi; Whaley-Connell, Adam; Sowers, James R.] Univ Missouri, Diabet & Cardiovasc Ctr, Sch Med, VA Med Ctr, Columbia, MO 65212 USA.
C3 University of Wyoming; University of Missouri System; University of
   Missouri Columbia
RP Sowers, JR (corresponding author), D109 HSC Diabet Ctr, 1 Hosp Dr, Columbia, MO 65212 USA.
EM sowersj@health.missouri.edu
RI Ren, Jun/ACG-5366-2022
OI Ren, Jun/0000-0002-0275-0783; Whaley-Connell, Adam/0000-0001-8955-5560
FU NIH [R01HL073101]; VA Merit; CDA-2 Dept of Veterans Affairs
FX Research included in this review is supported by NIH R01HL073101, VA
   Merit (JRS), and CDA-2 Dept of Veterans Affairs (AWC). The authors thank
   Brenda Hunter for her assistance in preparing this manuscript.
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NR 64
TC 280
Z9 309
U1 2
U2 37
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0946-2716
J9 J MOL MED
JI J. Mol. Med.
PD OCT
PY 2010
VL 88
IS 10
BP 993
EP 1001
DI 10.1007/s00109-010-0663-9
PG 9
WC Genetics & Heredity; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Genetics & Heredity; Research & Experimental Medicine
GA 652ZT
UT WOS:000282052100006
PM 20725711
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Chang, CC
   Chang, HA
   Chen, TY
   Fang, WH
   Huang, SY
AF Chang, Chuan-Chia
   Chang, Hsin-An
   Chen, Tien-Yu
   Fang, Wen-Hui
   Huang, San-Yuan
TI Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism affects
   sympathetic tone in a gender-specific way
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE Brain-derived neurotrophic factor (BDNF); Polymorphism; Sympathetic
   control; Autonomic nervous system (ANS); Heart rate variability (HRV)
ID HEART-RATE-VARIABILITY; POWER SPECTRUM ANALYSIS; HPA-AXIS REACTIVITY;
   PANIC DISORDER; PERIOD VARIABILITY; METABOLIC SYNDROME; VAGAL
   MODULATION; ANXIETY; STRESS; EXPRESSION
AB The Val/Val genotype of the brain-derived neurotrophic factor (BDNF) polymorphism (Val66Met) has been reported to affect human anxiety-related phenotypes. Substantial research has demonstrated that anxiety is associated with sympathetic activation, while sex steroid hormones have been shown to exert differential actions in regulating BDNF expression. Thus, we examined whether the BDNF variant modulates autonomic function in a gender-dependent manner. From 708 adults initially screened for medical and psychiatric illnesses, a final cohort of 583 drug-free healthy Han Chinese (355 males, 228 females; age 34.43 +/- 8.42 years) was recruited for BDNF genotyping (Val/Val: 136, 23.3%, Val/Met: 294, 50.4%, and Met/Met: 153, 26.2%). Time- and frequency-domain analyses of heart rate variability (HRV) were used to assess autonomic outflow to the heart. Significant genotype-by-gender interaction effects were found on HRV indices. Even after adjusting for possible confounders, male participants bearing the Val/Val genotype had significant increases in low frequency (LF), LF% and LF/high frequency (HF) ratio, indicating altered sympathovagal balance with increased sympathetic modulation, compared to male Met/Met homozygotes. Females, however, showed an opposite but non-significant pattern. These results suggest that the studied BDNF polymorphism is associated with sympathetic control in a gender-specific way. The findings here support the view that male subjects with the Val/Val genotype have increased risk of anxiety by association with sympathetic activation. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Chang, Chuan-Chia; Chang, Hsin-An; Chen, Tien-Yu; Huang, San-Yuan] Tri Serv Gen Hosp, Natl Def Med Ctr, Dept Psychiat, Taipei 114, Taiwan.
   [Chang, Chuan-Chia; Huang, San-Yuan] Natl Def Med Ctr, Grad Inst Med Sci, Taipei, Taiwan.
   [Fang, Wen-Hui] Tri Serv Gen Hosp, Natl Def Med Ctr, Dept Family & Community Med, Taipei 114, Taiwan.
C3 Tri-Service General Hospital; National Defense Medical Center; National
   Defense Medical Center; National Defense Medical Center; Tri-Service
   General Hospital
RP Huang, SY (corresponding author), Tri Serv Gen Hosp, Grad Inst Med Sci, Dept Psychiat, Natl Def Med Ctr, 325,Sec 2,Cheng Kung Rd, Taipei 114, Taiwan.
EM hsy@ndmctsgh.edu.tw
RI Cheng, Yeung/AFN-3087-2022; Chen, Han-Shen/E-5881-2018
OI Chang, Hsin-An/0000-0001-5572-7109; Chen, Tien-Yu/0000-0001-8462-1311
FU Tri-Service General Hospital, Taipei, Taiwan [TSGH-C101-120,
   TSGH-C102-122, TSGH-C103-130]
FX The authors thank Miss I-Ting Wang for her assistance in preparing this
   manuscript. This research was supported by grants from the Tri-Service
   General Hospital, Taipei, Taiwan (TSGH-C101-120, TSGH-C102-122, and
   TSGH-C103-130).
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NR 62
TC 21
Z9 21
U1 0
U2 17
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
EI 1873-3360
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD SEP
PY 2014
VL 47
BP 17
EP 25
DI 10.1016/j.psyneuen.2014.04.019
PG 9
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA AM2PY
UT WOS:000339694500003
PM 25001952
DA 2025-06-11
ER

PT J
AU Ling, GY
   Bruno, J
   Albert, SG
   Dhindsa, S
AF Ling, Guoyu
   Bruno, Jonathan
   Albert, Stewart G.
   Dhindsa, Sandeep
TI Fatty acids as a direct regulator of aldosterone hypersecretion
SO MOLECULAR AND CELLULAR ENDOCRINOLOGY
LA English
DT Article
DE Fatty acids non-esterified; Omega 3 fatty acid; Hyperaldosteronism;
   Obesity; Metabolic syndrome; Gene expression
ID METABOLIC SYNDROME; PLASMA-ALDOSTERONE; MITOCHONDRIAL BIOGENESIS;
   LONGITUDINAL CHANGES; INSULIN-RESISTANCE; ER STRESS; DYSFUNCTION;
   OBESITY; ASSOCIATION; SECRETION
AB Primary hyperaldosteronism is a major cause of secondary hypertension and carries additional cardiovascular risks beyond that of the elevated blood pressure. Primary hyperaldosteronism is more prevalent in obese people, and weight loss reduces aldosterone levels. It needs to be determined whether obesity related factors directly contribute to the pathogenesis of primary hyperaldosteronism. Here we show that the non-esterified fatty acids (NEFA) palmitic acid, and to a lesser extent, linoleic acid significantly stimulated aldosterone production and steroid enzyme induction in adrenocortical HAC15 cells of human origin. Palmitic acid, linoleic acid, and to a much lesser extent, oleic acid induced the expression of aldosterone synthase. Induction of the Steroidogenic Acute Regulatory Protein (StAR) was modest. Increased aldosterone secretion was independent of fatty acid beta -oxidation in the mitochondria but may involve free fatty acid receptor 1 (FFAR1/GPR40) and endoplasmic re-ticulum (ER) stress. Palmitic acid and linoleic acid induced the expression of C/EBP Homologous Protein (CHOP), a marker of ER stress, correlating with their ability to induce aldosterone synthase gene expression. Palmitic acid, but not linoleic acid decreased mitochondrial potentials and induced uncoupling protein 2 (UCP2). Palmitic acid enhanced, while docosahexaenoic acid (DHA) suppressed aldosterone response to angiotensin II (Ang-II). Our study provides evidence that NEFAs modulate aldosterone production, and further suggests that hyperaldosteronism shares similar pathogenesis with other obesity-related disorders such as metabolic syndrome.
C1 [Ling, Guoyu; Bruno, Jonathan; Albert, Stewart G.; Dhindsa, Sandeep] St Louis Univ Sch Med, Dept Internal Med, Div Endocrinol, St Louis, MO 63110 USA.
   [Ling, Guoyu] SLUcare Acad Pavil, Div Endocrinol, Internal Med, Room 2509,1008 South Spring St, St Louis, MO 63110 USA.
C3 Saint Louis University
RP Ling, GY (corresponding author), SLUcare Acad Pavil, Div Endocrinol, Internal Med, Room 2509,1008 South Spring St, St Louis, MO 63110 USA.
EM guoyu.ling@health.slu.edu
RI Bruno, Jonathan/KYQ-7906-2024; Albert, Stewart/AAY-8931-2021
OI Ling, Guoyu/0000-0001-8635-1116; Albert, Stewart/0000-0003-4621-6897
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NR 58
TC 3
Z9 3
U1 1
U2 5
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0303-7207
EI 1872-8057
J9 MOL CELL ENDOCRINOL
JI Mol. Cell. Endocrinol.
PD FEB 5
PY 2023
VL 561
AR 111836
DI 10.1016/j.mce.2022.111836
EA DEC 2022
PG 13
WC Cell Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Endocrinology & Metabolism
GA 7W5TY
UT WOS:000913576000001
PM 36549461
DA 2025-06-11
ER

PT J
AU Fisler, JS
   Warden, CH
AF Fisler, Janis S.
   Warden, Craig H.
TI Uncoupling proteins, dietary fat and the metabolic syndrome
SO NUTRITION & METABOLISM
LA English
DT Review
ID OXYGEN SPECIES PRODUCTION; BETA-CELL DYSFUNCTION; MIDDLE-AGED HUMANS;
   SKELETAL-MUSCLE; KNOCKOUT MICE; COMMON POLYMORPHISM; INSULIN-RESISTANCE;
   OXIDATIVE STRESS; GENE-EXPRESSION; TRANSGENIC MICE
AB There has been intense interest in defining the functions of UCP2 and UCP3 during the nine years since the cloning of these UCP1 homologues. Current data suggest that both UCP2 and UCP3 proteins share some features with UCP1, such as the ability to reduce mitochondrial membrane potential, but they also have distinctly different physiological roles. Human genetic studies consistently demonstrate the effect of UCP2 alleles on type-2 diabetes. Less clear is whether UCP2 alleles influence body weight or body mass index (BMI) with many studies showing a positive effect while others do not. There is strong evidence that both UCP2 and UCP3 protect against mitochondrial oxidative damage by reducing the production of reactive oxygen species. The evidence that UCP2 protein is a negative regulator of insulin secretion by pancreatic beta-cells is also strong: increased UCP2 decreases glucose stimulated insulin secretion ultimately leading to beta-cell dysfunction. UCP2 is also neuroprotective, reducing oxidative stress in neurons. UCP3 may also transport fatty acids out of mitochondria thereby protecting the mitochondria from fatty acid anions or peroxides. Current data suggest that UCP2 plays a role in the metabolic syndrome through down-regulation of insulin secretion and development of type-2 diabetes. However, UCP2 may protect against atherosclerosis through reduction of oxidative stress and both UCP2 and UCP3 may protect against obesity. Thus, these UCP1 homologues may both contribute to and protect from the markers of the metabolic syndrome.
C1 Univ Calif Davis, Rowe Program Genet, Dept Pediat, Div Clin Nutr Endocrinol & Vasc Biol, Davis, CA 95616 USA.
   Univ Calif Davis, Dept Nutr, Davis, CA 95616 USA.
   Univ Calif Davis, Sect Neurobiol Physiol & Behav, Davis, CA 95616 USA.
C3 University of California System; University of California Davis;
   University of California System; University of California Davis;
   University of California System; University of California Davis
RP Warden, CH (corresponding author), Univ Calif Davis, Rowe Program Genet, Dept Pediat, Div Clin Nutr Endocrinol & Vasc Biol, Davis, CA 95616 USA.
EM jfisler@earthlink.net; chwarden@ucdavis.edu
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NR 58
TC 93
Z9 102
U1 0
U2 7
PU BIOMED CENTRAL LTD
PI LONDON
PA MIDDLESEX HOUSE, 34-42 CLEVELAND ST, LONDON W1T 4LB, ENGLAND
SN 1743-7075
J9 NUTR METABOLISM
JI Nutr. Metab.
PD SEP 12
PY 2006
VL 3
AR 38
DI 10.1186/1743-7075-3-38
PG 7
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 093RX
UT WOS:000241187600001
PM 16968550
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Lim, S
   Eckel, RH
   Koh, KK
AF Lim, Soo
   Eckel, Robert H.
   Koh, Kwang Kon
TI Clinical implications of current cardiovascular outcome trials with
   sodium glucose cotransporter-2 (SGLT2) inhibitors
SO ATHEROSCLEROSIS
LA English
DT Review
DE Antidiabetic medications; Cardiovascular diseases; Prevention; Metabolic
   syndrome
ID INADEQUATE GLYCEMIC CONTROL; TYPE-2 DIABETES-MELLITUS; RENIN-ANGIOTENSIN
   SYSTEM; DOUBLE-BLIND; BLOOD-PRESSURE; URIC-ACID; BETA-HYDROXYBUTYRATE;
   OXIDATIVE STRESS; KIDNEY-DISEASE; LOWERING DRUGS
AB The final goal in the management of patients with type 2 diabetes (T2D) is reduction in cardiovascular (CV) complications and total mortality. Various factors including hyperglycemia contribute to these complications and mortality directly and indirectly. In recent years, large-scale CV outcome trials with new antidiabetic medications, such as dipeptidyl peptidase-4 (DPP4) inhibitors, glucagon-like peptide-1 (GLP1) receptor agonists, and sodium glucose cotransporter-2 (SGLT2) inhibitors, have been completed. Most clinical trials with DPP4 inhibitors have shown no inferiority compared with placebo treatments in terms of CV safety. However, they did not show benefits in terms of adverse CV events or mortality. CV outcome trials with GLP1 receptor agonists showed inconsistent results: lixisenatide did not show benefits in preventing major adverse CV events. In contrast, liraglutide and semaglutide (longer acting GLP1 receptor agonists) proved to be superior in terms of alleviating CV morbidity and mortality. Two large-scale CV outcome trials with SGLT2 inhibitors showed significant results: empagliflozin proved to be superior in preventing CV and all-cause mortality, and canagliflozin proved to be superior in preventing CV mortality but not all-cause mortality. So far, controlling cardiometabolic risk factors such as hemodynamic changes and weight loss by SGLT2 inhibitors are suggested to be the main mechanisms for these results. However, the risk-benefit profile for these new drugs will need further elucidation, and more studies are warranted to reveal the possible mechanisms. It will also be important to confirm these results from other ongoing trials with SGLT2 inhibitors. (C) 2018 Elsevier B.V. All rights reserved.
C1 [Lim, Soo] Seoul Natl Univ, Coll Med, Dept Internal Med, Seongnam, South Korea.
   [Lim, Soo] Seoul Natl Univ, Bundang Hosp, Seongnam, South Korea.
   [Eckel, Robert H.] Univ Colorado, Dept Med, Div Endocrinol Metab & Diabet, Anschutz Med Campus,12801 East 17th Ave,RC1 South, Aurora, CO 80045 USA.
   [Eckel, Robert H.] Univ Colorado, Dept Med, Div Cardiol, Anschutz Med Campus,12801 East 17th Ave,RC1 South, Aurora, CO 80045 USA.
   [Koh, Kwang Kon] Gachon Univ, Gil Med Ctr, Heart Ctr, Dept Cardiovasc Med, Incheon, South Korea.
   [Koh, Kwang Kon] Gachon Cardiovasc Res Inst, Incheon, South Korea.
C3 Seoul National University (SNU); Seoul National University (SNU);
   University of Colorado System; University of Colorado Anschutz Medical
   Campus; University of Colorado System; University of Colorado Anschutz
   Medical Campus; Gachon University
RP Eckel, RH (corresponding author), Univ Colorado, Dept Med, Div Endocrinol Metab & Diabet, Anschutz Med Campus,12801 East 17th Ave,RC1 South, Aurora, CO 80045 USA.; Eckel, RH (corresponding author), Univ Colorado, Dept Med, Div Cardiol, Anschutz Med Campus,12801 East 17th Ave,RC1 South, Aurora, CO 80045 USA.; Koh, KK (corresponding author), Gachon Univ, Gil Med Ctr, Dept Cardiovasc Med, Cardiometab Syndrome Unit, 774 Beongil 21, Incheon 21565, South Korea.
EM Robert.Eckel@ucdenver.edu; kwangk@gilhospital.com
RI Lim, Soo/AAU-8107-2020
OI Lim, Soo/0000-0002-4137-1671
FU Korea Health Industry Development Institute (KHIDI) - Ministry for
   Health and Welfare, Korea [HI15C0987, HI14C1135]; Korean Society of
   CardioMetabolic Syndrome
FX This work was supported by a grant of the Korea Health Technology R&D
   Project through the Korea Health Industry Development Institute (KHIDI)
   funded by the Ministry for Health and Welfare, Korea (HI15C0987 &
   HI14C1135) and the Korean Society of CardioMetabolic Syndrome.
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NR 76
TC 32
Z9 32
U1 0
U2 6
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0021-9150
EI 1879-1484
J9 ATHEROSCLEROSIS
JI Atherosclerosis
PD MAY
PY 2018
VL 272
BP 33
EP 40
DI 10.1016/j.atherosclerosis.2018.03.013
PG 8
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA GD3DT
UT WOS:000430383800006
PM 29547706
DA 2025-06-11
ER

PT J
AU Peña-Orihuela, P
   Camargo, A
   Rangel-Zuñiga, OA
   Perez-Martinez, P
   Cruz-Teno, C
   Delgado-Lista, J
   Yubero-Serrano, EM
   Paniagua, JA
   Tinahones, FJ
   Malagon, MM
   Roche, HM
   Perez-Jimenez, F
   Lopez-Miranda, J
AF Pena-Orihuela, Patricia
   Camargo, Antonio
   Alberto Rangel-Zuniga, Oriol
   Perez-Martinez, Pablo
   Cruz-Teno, Cristina
   Delgado-Lista, Javier
   Yubero-Serrano, Elena M.
   Paniagua, Juan A.
   Tinahones, Francisco J.
   Malagon, Maria M.
   Roche, Helen M.
   Perez-Jimenez, Francisco
   Lopez-Miranda, Jose
TI Antioxidant system response is modified by dietary fat in adipose tissue
   of metabolic syndrome patients
SO JOURNAL OF NUTRITIONAL BIOCHEMISTRY
LA English
DT Article
DE Metabolic syndrome; Oxidative stress; Antioxidant enzymes; Diet; Adipose
   tissue; LIPGENE study
ID POSTPRANDIAL OXIDATIVE STRESS; INSULIN-RESISTANCE; MACROPHAGE
   ACCUMULATION; THIOREDOXIN REDUCTASE; EXERCISE INTERVENTION;
   GENE-EXPRESSION; NADPH OXIDASE; INFLAMMATION; OBESITY; ACTIVATION
AB Metabolic syndrome (MetS) is associated with high oxidative stress, which is caused by an increased expression of NADPH-oxidase and a decreased expression of antioxidant enzymes in the adipose tissue. Our aim was to evaluate whether the quality and quantity of dietary fat can modify that process. A randomized, controlled trial conducted within the LIPGENE study assigned MetS patients to one of four diets for 12 wk each: (i) high-saturated fatty acid (HSFA), (ii) high-monounsaturated fatty acid (HMUFA), (iii) and (iv) two low-fat, high-complex carbohydrate diet supplemented with n-3 polyunsaturated fatty acids (LFHCC n3), or placebo (LFHCC). A fat challenge reflecting the same fatty acid composition as the original diets was conducted post-intervention. The intake of an HSFA meal induced a higher postprandial increase in gp91phox and p67phox mRNA levels than after the intake of HMUFA, LFHCC and LFHCC n-3 meals (all p-values < 0.05). The postprandial decrease in CAT, GPXs and TXNRD1 mRNA levels after the HSFA meal intake was higher than after the intake of HMUFA, LFHCC and LFHCC n-3 meals (all p-values < 0.05).The intake of an HSFA meal induced a higher postprandial increase in KEAP1 mRNA levels than after the consumption of the HMUFA (P = .007) and LFHCC n-3 (P = .001) meals. Our study demonstrated that monounsaturated fat consumption reduces oxidative stress as compared to saturated fat by inducing higher postprandial antioxidant response in adipose tissue, and thus, replacing SFA for MUFA may be an effective dietary strategy to reduce the oxidative stress in MetS patients and its pathophysiological consequences. (c) 2013 Elsevier Inc. All rights reserved.
C1 [Pena-Orihuela, Patricia; Camargo, Antonio; Alberto Rangel-Zuniga, Oriol; Perez-Martinez, Pablo; Cruz-Teno, Cristina; Delgado-Lista, Javier; Yubero-Serrano, Elena M.; Paniagua, Juan A.; Perez-Jimenez, Francisco; Lopez-Miranda, Jose] Univ Cordoba, Reina Sofia Univ Hosp, IMIBIC, Lipids & Atherosclerosis Res Unit, E-14004 Cordoba, Spain.
   [Pena-Orihuela, Patricia; Camargo, Antonio; Alberto Rangel-Zuniga, Oriol; Perez-Martinez, Pablo; Cruz-Teno, Cristina; Delgado-Lista, Javier; Yubero-Serrano, Elena M.; Paniagua, Juan A.; Perez-Jimenez, Francisco; Lopez-Miranda, Jose] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr CIBERobn, Madrid, Spain.
   [Tinahones, Francisco J.] Hosp Virgen de la Victoria, Malaga 29010, Spain.
   [Tinahones, Francisco J.] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr, Madrid, Spain.
   [Malagon, Maria M.] Univ Cordoba, Dept Cell Biol Physiol & Immunol, E-14071 Cordoba, Spain.
   [Roche, Helen M.] Univ Coll Dublin, UCD Sch Publ Hlth & Populat Sci, UCD Conway Inst, Nutrigen Res Grp, Dublin, Ireland.
C3 Universidad de Cordoba; Instituto de Salud Carlos III; CIBER - Centro de
   Investigacion Biomedica en Red; CIBEROBN; Hospital Virgen de la
   Victoria; CIBER - Centro de Investigacion Biomedica en Red; CIBEROBN;
   Instituto de Salud Carlos III; Universidad de Cordoba; University
   College Dublin
RP Lopez-Miranda, J (corresponding author), Hosp Univ Reina Sofia, Med Interna Serv, Unidad Lipidos & Arteriosclerosis, Avda Menendez Pidal S-N, Cordoba 14004, Spain.
EM jlopezmir@uco.es
RI Delgado-Lista, Javier/KAM-7412-2024; Jimenez, Francisco/AAJ-9559-2021;
   Tinahones, Francisco/AAB-2882-2020; Lopez-Miranda, Jose/Y-8306-2019;
   Yubero-Serrano, Elena/H-4832-2013; Perez Martinez, Pablo/AEL-6176-2022;
   MALAGON, MARIA M/L-5386-2014; Camargo Garcia, Antonio/G-9720-2015
OI Delgado Lista, Francisco Javier/0000-0002-2982-2716; Perez Martinez,
   Pablo/0000-0001-7716-8117; Yubero-Serrano, Elena M/0000-0002-2733-5359;
   Pena Orihuela, Patricia J/0009-0009-9970-043X; Perez-Jimenez,
   Francisco/0000-0001-7499-7681; Rangel-Zuniga, Oriol
   Alberto/0000-0003-3495-5705; Roche, Helen/0000-0002-0628-3318; , Juan A.
   Paniagua/0000-0003-2892-980X; Perez Jimenez,
   Francisco/0000-0001-9808-1280; MALAGON, MARIA M/0000-0002-2419-2727;
   Tinahones, Francisco J/0000-0001-6871-4403; Camargo Garcia,
   Antonio/0000-0002-0415-4184; Lopez-Miranda, Jose/0000-0002-8844-0718
FU European community [505944]; Spanish Ministry of Health [CB06/03/0047];
   Ministerio de Ciencia e Innovacion [AGL2006-01979/ALI, AGL2009-12270,
   SAF2007-62005]; Consejeria de Innovacion, Ciencia y Empresa, Proyectos
   de Investigacion de Excelencia Junta de Andalucia [AGR 05/00922, CT5015,
   P06-CTS-01425]; Consejeria de Salud, Junta de Andalucia [06/128, 07/43,
   PI 0193/09, 06/129]; Centro de Excelencia Investigadora Aceite de Oliva
   y Salud (CEAS); FEDER; Fondo Social Europeo
FX This study was supported partly by research grants from the European
   community (LIPGENE European proyect-505944), the Spanish Ministry of
   Health (CB06/03/0047 (CIBER Fisiopatologia de la Obesidad y Nutricion)
   and the following Spanish entities: Ministerio de Ciencia e Innovacion
   (AGL2006-01979/ALI, AGL2009-12270 to JL-M and SAF2007-62005 to FP-J),
   Consejeria de Innovacion, Ciencia y Empresa, Proyectos de Investigacion
   de Excelencia Junta de Andalucia (AGR 05/00922 and CT5015 to FP-J and
   P06-CTS-01425 to JL-M); Consejeria de Salud, Junta de Andalucia (06/128,
   07/43, PI 0193/09 to JL-M, 06/129 to FP-J), Centro de Excelencia
   Investigadora Aceite de Oliva y Salud (CEAS), FEDER, Fondo Social
   Europeo. PP-O has a fellowship from Programa de Formacion de Profesorado
   Universitario (FPU), Ministerio de Educacion. Gobierno de Espana.
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NR 49
TC 26
Z9 26
U1 0
U2 18
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0955-2863
EI 1873-4847
J9 J NUTR BIOCHEM
JI J. Nutr. Biochem.
PD OCT
PY 2013
VL 24
IS 10
BP 1717
EP 1723
DI 10.1016/j.jnutbio.2013.02.012
PG 7
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA 227OK
UT WOS:000325123000006
PM 23647888
DA 2025-06-11
ER

PT J
AU Jha, SK
   Jha, NK
   Kumar, D
   Ambasta, RK
   Kumar, P
AF Jha, Saurabh Kumar
   Jha, Niraj Kumar
   Kumar, Dhiraj
   Ambasta, Rashmi K.
   Kumar, Pravir
TI Linking mitochondrial dysfunction, metabolic syndrome and stress
   signaling in Neurodegeneration
SO BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
LA English
DT Article
DE Mitochondrial dysfunction; Metabolic syndrome (Mets); Neurodegenerative
   disorders (NDDs); Therapeutics; Biomoleades; Chaperones
ID AMYOTROPHIC-LATERAL-SCLEROSIS; DENSITY-LIPOPROTEIN-CHOLESTEROL; PROTECTS
   PC12 CELLS; ALZHEIMERS-DISEASE; MOUSE MODEL; OXIDATIVE STRESS;
   PARKINSONS-DISEASE; INSULIN-RESISTANCE; HUNTINGTON-DISEASE; DNA-DAMAGE
AB Mounting evidence suggests a link between metabolic syndrome (MetS) such as diabetes, obesity, non-alcoholic fatty liver disease in the progression of Alzheimer's disease (AD), Parkinson's disease (PD) and other neurodegenerative diseases (NDDs). For instance, accumulated Ala oligomer is enhancing neuronal Ca2+ release and neural NO where increased NO level in the brain through post translational modification is modulating the level of insulin production. It has been further confirmed that irrespective of origin; brain insulin resistance triggers a cascade of the neurodegeneration phenomenon which can be aggravated by free reactive oxygen species burden, ER stress, metabolic dysfunction, neuorinflammation, reduced cell survival and altered lipid metabolism. Moreover, several studies confirmed that MetS and diabetic sharing common mechanisms in the progression of AD and NDDs where mitochondria! dynamics playing a critical role. Any mutation in mitochondrial DNA, exposure of environmental toxin, high-calorie intake, homeostasis imbalance, glucolipotoxicity is causative factors for mitochondrial dysfunction. These cumulative pleiotropic burdens in mitochondria leads to insulin resistance, increased ROS production; enhanced stress-related enzymes that is directly linked MetS and diabetes in neurodegeneration. Since, the linkup mechanism between mitochondrial dysfunction and disease phenomenon of both MetS and NDDs is quite intriguing, therefore, it is pertinent for the researchers to identify and implement the therapeutic interventions for targeting MetS and NDDs. Herein, we elucidated the pertinent role of MetS induced mitochondrial dysfunction in neurons and their consequences in NDDs. Further, therapeutic potential of well-known biomolecules and chaperones to target altered mitochondria has been comprehensively documented. This article is part of a Special Issue entitled: Oxidative Stress and Mitochondrial Quality in Diabetes/Obesity and Critical Illness Spectrum of Diseases - edited by P. Hemachandra Reddy. (C) 2016 Elsevier B.V. All rights reserved.
C1 [Jha, Saurabh Kumar; Jha, Niraj Kumar; Kumar, Dhiraj; Ambasta, Rashmi K.; Kumar, Pravir] Delhi Technol Univ, DCE, Dept Biotechnol, Mol Neurosci & Funct Genom Lab, Delhi 110042, India.
C3 Delhi Technological University
RP Kumar, P (corresponding author), Delhi Technol Univ, Dept Biotechnol, Delhi Coll Engn, Room FW4TF3,Mech Engn Bldg,Bawana Rd, Delhi 110042, India.
EM pravirkumar@dce.edu
RI Ambasta, Rashmi/K-8611-2019; Jha, Nandan/AAX-9516-2020; Jha, Dr.
   Saurabh/ACC-9874-2022; Kumar, Pravir/AAR-1207-2020; , DHIRAJ
   KUMAR/AAT-9785-2021
OI Jha, Dr.Saurabh kumar/0000-0002-7437-0755; , DHIRAJ
   KUMAR/0000-0001-5820-4792; Jha, Dr. Niraj Kumar/0000-0001-9486-4069;
   Kumar, Pravir/0000-0001-7444-2344
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NR 198
TC 82
Z9 88
U1 1
U2 25
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0925-4439
EI 1879-260X
J9 BBA-MOL BASIS DIS
JI Biochim. Biophys. Acta-Mol. Basis Dis.
PD MAY
PY 2017
VL 1863
IS 5
SI SI
BP 1132
EP 1146
DI 10.1016/j.bbadis.2016.06.015
PG 15
WC Biochemistry & Molecular Biology; Biophysics; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Cell Biology
GA EU5BO
UT WOS:000401046800012
PM 27345267
DA 2025-06-11
ER

PT J
AU Milankov, A
   Milanovic, M
   Milosevic, N
   Sudji, J
   Pejakovic, S
   Milic, N
   Bjelica, A
   Stojanoska, MM
AF Milankov, Andrijana
   Milanovic, Maja
   Milosevic, Natasa
   Sudji, Jan
   Pejakovic, Sladana
   Milic, Natasa
   Bjelica, Artur
   Stojanoska, Milica Medic
TI The effects of phthalate exposure on metabolic parameters in polycystic
   ovary syndrome
SO CLINICA CHIMICA ACTA
LA English
DT Article
DE Phthalates; Endocrine disruptors; Polycystic ovary syndrome; Obesity;
   Hyperinsulinemia; Dyslipidaemia
ID POLLUTANT BISPHENOL-A; CARDIOMETABOLIC RISK; OXIDATIVE STRESS; HORMONES;
   HEALTH; INDEX; WOMEN; PCOS
AB Background-aim: Phthalates are known as endocrine disrupting chemicals which are present in wide-range of products. The objective of the study was to investigate whether phthalate exposure may attribute to the metabolic syndrome development in women with polycystic ovary syndrome (PCOS). Method: The cross-sectional study involved 60 women in reproductive age with confirmed PCOS. Anthropometric and biochemical measurements were examined together with detected levels of ten phthalate metabolites measured by GC-MS in morning urine samples. Results: In this study at least one phthalate metabolite was detected in 51.7% of samples. Total phthalate metabolites urine concentrations were positively associated with BMI, waist circumference, waist-to-height-ratio (WtHR), leptin serum levels as well as lipid accumulation product (LAP) and visceral adiposity index (VAI). Mono-methyl-phthalate (MMP) levels was significantly correlated with WtHR, LAP and VAI. Additionally, total phthalate metabolites levels were significantly linked with fasting plasma glucose and HOMA index, whereas MMP concentrations were associated with fasting plasma glucose and insulin levels. Total cholesterol (TC) level was statistically significantly higher among PCOS women with detected phthalate metabolites compared to those without phthalates. The sum of all phthalates was correlated with LDL and triglyceride levels as well as TC/HDL. MMP concentrations were linked positively with TC, LDL and triglyceride levels as well as with TC/HDL. It is noteworthy that MMP concentrations were positively associated with testosterone serum levels while the total phthalate metabolites concentrations were also linked but with moderate significance. Conclusions: The increased phthalate metabolites concentrations may interfere with obesity, glucose and lipid impairment in PCOS women. Additionally, testosterone serum levels can be disrupted by MMP.
C1 [Milankov, Andrijana; Pejakovic, Sladana; Stojanoska, Milica Medic] Univ Novi Sad, Univ Clin Ctr Vojvodina, Fac Med, Clin Endocrinol Diabet & Metab Dis, Novi Sad, Serbia.
   [Milanovic, Maja; Sudji, Jan; Milic, Natasa] Univ Novi Sad, Fac Med, Dept Pharm, Novi Sad, Serbia.
   [Bjelica, Artur] Univ Novi Sad, Univ Clin Ctr Vojvodina, Fac Med, Dept Obstet & Gynecol, Novi Sad, Serbia.
   [Milanovic, Maja] Univ Novi Sad, Fac Med, Dept Pharm, Hajduk Veljkova 3, Novi Sad 21000, Serbia.
C3 University of Novi Sad; University of Novi Sad; University of Novi Sad;
   University of Novi Sad
RP Milanovic, M (corresponding author), Univ Novi Sad, Fac Med, Dept Pharm, Hajduk Veljkova 3, Novi Sad 21000, Serbia.
EM maja.milanovic@mf.uns.ac.rs
RI Milanović, Maja/JXN-5115-2024
OI Milanovic, Maja/0000-0003-4082-5480; Milic, Natasa/0000-0002-8595-6065;
   Milosevic, Natasa/0000-0002-5286-3858
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NR 45
TC 12
Z9 13
U1 3
U2 23
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0009-8981
EI 1873-3492
J9 CLIN CHIM ACTA
JI Clin. Chim. Acta
PD FEB 1
PY 2023
VL 540
AR 117225
DI 10.1016/j.cca.2023.117225
EA JAN 2023
PG 6
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA 8N4UP
UT WOS:000925145100001
PM 36627009
DA 2025-06-11
ER

PT J
AU Wlodarski, A
   Strycharz, J
   Wróblewski, A
   Kasznicki, J
   Drzewoski, J
   Sliwinska, A
AF Wlodarski, Adam
   Strycharz, Justyna
   Wroblewski, Adam
   Kasznicki, Jacek
   Drzewoski, Jozef
   Sliwinska, Agnieszka
TI The Role of microRNAs in Metabolic Syndrome-Related Oxidative Stress
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE microRNAs; oxidative stress; reactive oxygen species; prooxidant
   enzymes; antioxidative enzymes; antioxidative genes; metabolic syndrome;
   obesity; insulin resistance; diabetes
ID INDUCED INSULIN-RESISTANCE; ENDOTHELIAL-CELL APOPTOSIS; OXYGEN SPECIES
   GENERATION; VISCERAL FAT ACCUMULATION; GLYCATION END-PRODUCTS;
   GLUCOSE-INDUCED INJURY; B TYPE-I; UP-REGULATION; ADIPOSE-TISSUE;
   DENSITY-LIPOPROTEIN
AB Oxidative stress (OxS) is the cause and the consequence of metabolic syndrome (MetS), the incidence and economic burden of which is increasing each year. OxS triggers the dysregulation of signaling pathways associated with metabolism and epigenetics, including microRNAs, which are biomarkers of metabolic disorders. In this review, we aimed to summarize the current knowledge regarding the interplay between microRNAs and OxS in MetS and its components. We searched PubMed and Google Scholar to summarize the most relevant studies. Collected data suggested that different sources of OxS (e.g., hyperglycemia, insulin resistance (IR), hyperlipidemia, obesity, proinflammatory cytokines) change the expression of numerous microRNAs in organs involved in the regulation of glucose and lipid metabolism and endothelium. Dysregulated microRNAs either directly or indirectly affect the expression and/or activity of molecules of antioxidative signaling pathways (SIRT1, FOXOs, Keap1/Nrf2) along with effector enzymes (e.g., GPx-1, SOD1/2, HO-1), ROS producers (e.g., NOX4/5), as well as genes of numerous signaling pathways connected with inflammation, insulin sensitivity, and lipid metabolism, thus promoting the progression of metabolic imbalance. MicroRNAs appear to be important epigenetic modifiers in managing the delicate redox balance, mediating either pro- or antioxidant biological impacts. Summarizing, microRNAs may be promising therapeutic targets in ameliorating the repercussions of OxS in MetS.
C1 [Wlodarski, Adam; Kasznicki, Jacek] Med Univ Lodz, Dept Internal Dis Diabetol & Clin Pharmacol, PL-92213 Lodz, Poland.
   [Strycharz, Justyna; Wroblewski, Adam] Med Univ Lodz, Dept Med Biochem, PL-92215 Lodz, Poland.
   [Drzewoski, Jozef] Med Univ Lodz, Cent Teaching Hosp, PL-92213 Lodz, Poland.
   [Sliwinska, Agnieszka] Med Univ Lodz, Dept Nucle Acid Biochem, PL-92213 Lodz, Poland.
C3 Medical University Lodz; Medical University Lodz; Medical University
   Lodz; Medical University Lodz
RP Wlodarski, A (corresponding author), Med Univ Lodz, Dept Internal Dis Diabetol & Clin Pharmacol, PL-92213 Lodz, Poland.; Strycharz, J (corresponding author), Med Univ Lodz, Dept Med Biochem, PL-92215 Lodz, Poland.; Sliwinska, A (corresponding author), Med Univ Lodz, Dept Nucle Acid Biochem, PL-92213 Lodz, Poland.
EM adam.wroblewski@stud.umed.lodz.pl; justyna.strycharz@umed.lodz.pl;
   adam.wlodarski@stud.umed.lodz.pl; jacek.kasznicki@umed.lodz.pl;
   jozef.drzewoski@umed.lodz.pl; agnieszka.sliwinska@umed.lodz.pl
RI Wroblewski, Adam/NJS-0795-2025; Sliwinska, Agnieszka/S-9813-2016;
   Strycharz, Justyna/AAL-7918-2020
OI Wlodarski, Adam/0000-0002-8691-7551; , Jacek/0000-0002-5479-8260;
   Strycharz, Justyna/0000-0002-3817-0377; Wroblewski,
   Adam/0000-0002-6414-7111; Sliwinska, Agnieszka/0000-0002-6864-0704
FU Medical University of Lodz [503/0-077-09/503-01-006-17]; Polish Society
   of Metabolic Disorders
FX The paper was supported by Medical University of Lodz (grant number
   503/0-077-09/503-01-006-17) and Polish Society of Metabolic Disorders.
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NR 389
TC 57
Z9 59
U1 0
U2 22
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD SEP
PY 2020
VL 21
IS 18
AR 6902
DI 10.3390/ijms21186902
PG 54
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA OF7VN
UT WOS:000581410300001
PM 32962281
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Kotani, K
   Yamada, T
AF Kotani, Kazuhiko
   Yamada, Toshiyuki
TI Oxidative stress and metabolic syndrome in a Japanese female population
SO AUSTRALASIAN JOURNAL ON AGEING
LA English
DT Article
DE d-ROMs test; metabolic syndrome; obesity; reactive oxygen species
ID TOTAL ANTIOXIDANT CAPACITY; HEART-DISEASE; BIOMARKERS; MARKERS; OBESITY;
   IMPACT; ASSAY
AB Aim: One of the methods to evaluate oxidative stress in clinical medical settings is the reactive oxygen metabolites (d-ROMs) test. While metabolic syndrome (MetS) is considered an oxidative condition, the oxidative status in MetS has not been fully examined using this test. The aim of the present study was to investigate the possible association between oxidative stress as evaluated by the d-ROMs test and the MetS component number, in a Japanese female population. Methods: The serum oxidant capacity (measured by the d-ROMs test) was cross-sectionally determined in cardiovascular disease-free and non-smoking women who were not taking medications (n= 180; mean age, 60 +/- 10 (standard deviation) years). Their MetS state was determined by the National Cholesterol Education Program Adult Treatment Panel recommendations with minor modifications for a Japanese population. Results: Patients with MetS (n= 60, 362 +/- 53 CARR U) showed a significantly higher oxidant capacity by d-ROMs than those without MetS (n= 120, 324 +/- 55 CARR U, P < 0.01). Moreover, the significant increase in the oxidant capacity by d-ROMs was closely associated with an increase in the MetS component number (trend P < 0.01). Conclusions: These results showed a significantly positive association between the oxidant capacity (by d-ROMs) and the MetS component number in this population. Further studies are required to establish the clinical applications of this test to MetS practice and clarify the biological mechanisms of the observed relationships.
EM kazukotani@jichi.ac.jp
FU Ministry of Education, Culture, Sports, Science, and Technology of Japan
FX This study was supported in part by a Grant-in-Aid for the Scientific
   Research from the Ministry of Education, Culture, Sports, Science, and
   Technology of Japan (K.K.).
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NR 32
TC 7
Z9 11
U1 0
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1440-6381
EI 1741-6612
J9 AUSTRALAS J AGEING
JI Australas. Ageing
PD JUN
PY 2012
VL 31
IS 2
BP 124
EP 127
DI 10.1111/j.1741-6612.2011.00571.x
PG 4
WC Geriatrics & Gerontology; Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA 954ZE
UT WOS:000304985900011
PM 22676173
DA 2025-06-11
ER

PT J
AU Abdilla, N
   Tormo, MC
   Fabia, MJ
   Chaves, FJ
   Saez, G
   Redon, J
AF Abdilla, N.
   Tormo, M. C.
   Fabia, M. J.
   Chaves, F. J.
   Saez, G.
   Redon, J.
TI Impact of the components of metabolic syndrome on oxidative stress and
   enzymatic antioxidant activity in essential hypertension
SO JOURNAL OF HUMAN HYPERTENSION
LA English
DT Article
DE essential hypertension; oxidative stress; metabolic syndrome;
   antioxidant mechanisms
ID BY-PRODUCTS; PROTEIN DAMAGE; GLUTATHIONE; PROTEOLYSIS; GLUCOSE; PLASMA
AB The objective of the present study was to analyze the impact of metabolic syndrome ( MS) and its individual components on oxidative stress ( OX) and on the activity of antioxidant enzymes of patients with essential hypertension. One hundred and eighty-seven hypertensives, 127 (61.9%) of them having criteria for MS according to the International Diabetes Federation criteria and 30 healthy normotensive subjects were included. OX status was assessed by measuring glutathione oxidized/glutathione reduced and reactive oxygen species-induced byproducts of lipid peroxidation, malondialdehide, and DNA damage, 8-oxo-dG genomic and mitochondrial. Antioxidant enzymatic activity of Cu/Zn extracellular-superoxide dismutase ( SOD) and catalase ( CAT) was measured in plasma and glutathione peroxidase 1 in hemolysad erythrocytes. In mononuclear cells, total-SOD activity, CAT and glutathione peroxidase 1, were assessed as well. The OX state in both blood and peripheral mononuclear cells observed in hypertensives were not enhanced by the addition of components of the so-called MS. Likewise, the reduction in the activity of antioxidant enzymes, both extracellular and cytoplasmic, was not affected by the presence of additional components of the MS. Neither the number of components nor the individual addition of each of them, low high-density lipoprotein, triglycerides, abdominal obesity or fasting glucose, further impact in the OX abnormalities observed in those with only hypertension in absence of other components. In conclusion, the present data indicates that contribution of MS components to the OX burden generated by high blood pressure is minimal.
C1 Univ Valencia, Hosp Clin, Hypertens Clin, Valencia 46010, Spain.
   Univ Valencia, Sch Med, Dept Biochem & Mol Biol, Valencia, Spain.
   Univ Valencia, Fdn Hosp Clin, Res Unit, Valencia, Spain.
C3 University of Valencia; University of Valencia; University of Valencia
RP Redon, J (corresponding author), Univ Valencia, Hosp Clin, Hypertens Clin, 17 Av Blasco Ibanez, Valencia 46010, Spain.
EM josep.redon@uv.es
RI Redon, Josep/L-5997-2019; CHAVES, FELIPE/ABC-3294-2021
OI CHAVES, FELIPE J/0000-0001-8009-3689; Saez,
   Guillermo/0000-0002-8164-4048; Redon, Josep/0000-0001-8777-6773
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NR 31
TC 54
Z9 61
U1 0
U2 3
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0950-9240
EI 1476-5527
J9 J HUM HYPERTENS
JI J. Hum. Hypertens.
PD JAN
PY 2007
VL 21
IS 1
BP 68
EP 75
DI 10.1038/sj.jhh.1002105
PG 8
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 117RI
UT WOS:000242890200011
PM 17066087
DA 2025-06-11
ER

PT J
AU Motykova, E
   Zlatohlavek, L
   Prusikova, M
   Lanska, V
   Ceska, R
   Vasickova, L
   Vrablik, M
AF Motykova, Eva
   Zlatohlavek, Lukas
   Prusikova, Martina
   Lanska, Vera
   Ceska, Richard
   Vasickova, Ludmila
   Vrablik, Michal
TI Lifestyle modification induced weight loss and changes of
   cardiometabolic risk factors including lowering of inflammatory response
   in obese children
SO NEUROENDOCRINOLOGY LETTERS
LA English
DT Article
DE obesity; atherosclerosis; cardiovascular risk; children; lipoprotein
   associated phospholipase A2, (Lp-PLA2); weight loss
ID CARDIOVASCULAR-DISEASE RISK; PHOSPHOLIPASE A(2); METABOLIC SYNDROME;
   CHILDHOOD OBESITY; OXIDATIVE STRESS; ATHEROSCLEROSIS; EPIDEMIOLOGY;
   ADOLESCENTS; OVERWEIGHT; MARKER
AB OBJECTIVES: Obesity is associated with increased inflammation which represents a link to atherosclerosis and cardiovascular disease. Lipoprotein associated phospholipase A2 (Lp-PLA2) is an independent marker of inflammation and atherosclerosis risk. To assess the impact of weight loss on metabolic markers of atherosclerosis including Lp-PLA2 we examined a group of Czech non-diabetic obese/overweight children exposed to a lifestyle intervention.
   PATIENTS AND METHODS: Fourty unrelated overweight/obese non-diabetic Czech children (13.7 +/- 2.1 years, average BMI at baseline 29.8 +/- 2.6 kg/m(2)) underwent 4 weeks of lifestyle modification (reduction of energy intake to age matched optimum and supervised physical activity). Anthropometrical and biochemical variables were determined at baseline and after the intervention. Lp-PLA2 mass concentration was assessed using the ELISA kit. Wilcocson's rank test and Spearman's correlation were used for statistical analysis.
   RESULTS: A significant decrease of BMI and waist circumference was associated with significant changes of plasma lipoprotein and glycaemia levels. Mass concentration of Lp-PLA2 at the baseline was 402 +/- 94 mu g/ml, after the intervention 368 +/- 105 mu g/ml (p=0.008). Change in Lp-PLA2 was associated with triglyceride level decrease (p=0.009).
   CONCLUSION: Intensive lifestyle modification leading to body weight decrease results in significant changes of plasma lipoprotein levels and, also, a drop of Lp-PLA2 levels in paediatric obese patients. However, even after the intervention Lp-PLA2 concentrations in this patient group remain elevated suggesting possible increased atherosclerosis risk in later life.
C1 [Motykova, Eva; Zlatohlavek, Lukas; Prusikova, Martina; Ceska, Richard; Vrablik, Michal] Charles Univ Prague, Dept Internal Med 3, Gen Teaching Hosp, Prague 12808 2, Czech Republic.
   [Motykova, Eva; Zlatohlavek, Lukas; Prusikova, Martina; Ceska, Richard; Vrablik, Michal] Charles Univ Prague, Fac Med 1, Prague 12808 2, Czech Republic.
   [Lanska, Vera] Inst Clin & Expt Med, Prague, Czech Republic.
   [Vasickova, Ludmila] Dr Filips Inst Children, Podebrady, Czech Republic.
C3 General University Hospital Prague; Charles University Prague; Charles
   University Prague; Institute for Clinical & Experimental Medicine (IKEM)
RP Vrablik, M (corresponding author), Charles Univ Prague, Internal Dept 3, Gen Teaching Hosp, U Nemocnice 1, Prague 12808 2, Czech Republic.
EM michal.vrablik@lf1.cuni.cz
RI lachat, carl/AAH-9764-2020; Vrablik, Michal/B-4590-2017; Zlatohlavek,
   Lukas/E-1276-2017; Tumova, Eva/Q-6472-2017; Vaclova,
   Martina/S-9395-2017; Ceska, Richard/A-1840-2017
OI Vrablik, Michal/0000-0002-7226-1926; Zlatohlavek,
   Lukas/0000-0001-6550-2587; Tumova, Eva/0000-0002-1588-0739; Vaclova,
   Martina/0000-0003-4587-6906; Ceska, Richard/0000-0002-2541-5179
FU Internal Grant Agency of the Ministry of Health of the Czech Republic
   [NS 10589-3]
FX The study was supported by a grant No. NS 10589-3 from the Internal
   Grant Agency of the Ministry of Health of the Czech Republic.
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NR 18
TC 7
Z9 7
U1 0
U2 6
PU MAGHIRA & MAAS PUBLICATIONS
PI MUNSBACH
PA MAGHIRA & MAAS S A R L, 6C, RUE GABRIEL LIPPMANN, L-5365 MUNSBACH,
   LUXEMBOURG
SN 0172-780X
EI 2354-4716
J9 NEUROENDOCRINOL LETT
JI Neuroendocrinol. Lett.
PY 2011
VL 32
SU 2
BP 55
EP 59
PG 5
WC Endocrinology & Metabolism; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology
GA 896CY
UT WOS:000300544200013
PM 22101884
DA 2025-06-11
ER

PT J
AU Morel, S
   Léveillé, P
   Samoilenko, M
   Franco, A
   England, J
   Malaquin, N
   Tu, V
   Cardin, GB
   Drouin, S
   Rodier, F
   Lippé, S
   Krajinovic, M
   Laverdière, C
   Sinnett, D
   Lefebvre, G
   Levy, E
   Marcil, V
AF Morel, Sophia
   Leveille, Pauline
   Samoilenko, Mariia
   Franco, Anita
   England, Jade
   Malaquin, Nicolas
   Tu, Veronique
   Cardin, Guillaume B.
   Drouin, Simon
   Rodier, Francis
   Lippe, Sarah
   Krajinovic, Maja
   Laverdiere, Caroline
   Sinnett, Daniel
   Lefebvre, Genevieve
   Levy, Emile
   Marcil, Valerie
TI Biomarkers of cardiometabolic complications in survivors of childhood
   acute lymphoblastic leukemia
SO SCIENTIFIC REPORTS
LA English
DT Article
ID LIPOPOLYSACCHARIDE-BINDING PROTEIN; YOUNG-ADULT SURVIVORS;
   NECROSIS-FACTOR-ALPHA; LONG-TERM SURVIVORS; BODY-MASS INDEX;
   CARDIOVASCULAR RISK-FACTORS; SOLUBLE ADHESION MOLECULES; VISCERAL FAT
   ACCUMULATION; CORONARY-HEART-DISEASE; BREAST-CANCER PATIENTS
AB Survivors of childhood acute lymphoblastic leukemia (cALL) are at higher risk of developing cardiometabolic complications. We aimed at exploring the associations between biomarkers of inflammation, oxidative stress, endothelial function, endotoxemia and cardiometabolic risk factors. We conducted a cross-sectional analysis in 246 cALL survivors (mean age, 22.1 +/- 6.3 years; mean time since diagnosis, 15.5 +/- 5.2 years) and evaluated the associations using a series of logistic regressions. Using structural equation models, we also tested if the relationship between endotoxemia and cardiometabolic complications was mediated by the latent (unobserved) variable inflammation inferred from the observed biomarkers CRP, TNF-alpha and IL-6. High leptin-adiponectin ratio was associated with obesity [adjusted OR=15.7; 95% CI (6.2-39.7)], insulin resistance [20.6 (5.2-82.1)] and the metabolic syndrome [11.2 (2.6-48.7)]. Higher levels of plasminogen activator inhibitor-1 and tumor necrosis factor-alpha were associated with obesity [3.37 (1.6-7.1) and 2.34 (1.3-4.2), respectively] whereas high C-reactive protein levels were associated with insulin resistance [3.3 (1.6-6.8)], dyslipidemia [2.6 (1.4-4.9)] and MetS [6.5 (2.4-17.9)]. Our analyses provided evidence for a directional relationship between lipopolysaccharide binding protein, related to metabolic endotoxemia, inflammation and cardiometabolic outcomes. Identification of biomarkers and biological mechanisms could open new avenues for prevention strategies to minimize the long-term sequelae, improve follow-up and optimize the quality of life of this high-risk population.
C1 [Morel, Sophia; Leveille, Pauline; Samoilenko, Mariia; Franco, Anita; England, Jade; Drouin, Simon; Lippe, Sarah; Krajinovic, Maja; Sinnett, Daniel; Levy, Emile; Marcil, Valerie] Univ Montreal, St Justine Univ Hlth Ctr, Res Ctr, 3175 Cote St Catherine Room 4-17-006, Montreal, PQ H3T 1C5, Canada.
   [Leveille, Pauline; Lippe, Sarah] Univ Montreal, Dept Psychol, Montreal, PQ H3T 1C5, Canada.
   [Samoilenko, Mariia; Lefebvre, Genevieve] Univ Quebec Montreal, Dept Math, Montreal, PQ H3C 3P8, Canada.
   [England, Jade; Krajinovic, Maja; Laverdiere, Caroline; Sinnett, Daniel] Univ Montreal, Dept Pediat, Montreal, PQ H3T 1C5, Canada.
   [Morel, Sophia; Levy, Emile; Marcil, Valerie] Univ Montreal, Dept Nutr, Montreal, PQ H3T 1C5, Canada.
   [Malaquin, Nicolas; Tu, Veronique; Cardin, Guillaume B.; Rodier, Francis] CRCHUM, Montreal, PQ H2X 0A9, Canada.
   [Malaquin, Nicolas; Tu, Veronique; Cardin, Guillaume B.; Rodier, Francis] Inst Canc Montreal, Montreal, PQ H2X 0A9, Canada.
   [Rodier, Francis] Univ Montreal, Dept Radiol Radiooncol & Nucl Med, Montreal, PQ H3T 1C5, Canada.
C3 Universite de Montreal; Universite de Montreal; University of Quebec;
   University of Quebec Montreal; Universite de Montreal; Universite de
   Montreal; Universite de Montreal; Universite de Montreal; Universite de
   Montreal
RP Marcil, V (corresponding author), Univ Montreal, St Justine Univ Hlth Ctr, Res Ctr, 3175 Cote St Catherine Room 4-17-006, Montreal, PQ H3T 1C5, Canada.; Marcil, V (corresponding author), Univ Montreal, Dept Nutr, Montreal, PQ H3T 1C5, Canada.
EM valerie.marcil@umontreal.ca
OI Drouin, Simon/0000-0003-1686-544X
FU Institute of Cancer Research (ICR) of the Canadian Institutes of Health
   Research (CIHR); C17 Council; Canadian Cancer Society (CCS); Cancer
   Research Society (CRS); Garron Family Cancer Centre at the Hospital for
   Sick Children; Ontario Institute for Cancer Research (OICR); Pediatric
   Oncology Group of Ontario (POGO) [TCF 118694]; Fonds de la Recherche du
   Quebec-Sante (FRQ-S) [33070]; Institut du cancer de Montreal (ICM); Cole
   Foundation
FX This work was supported by the Institute of Cancer Research (ICR) of the
   Canadian Institutes of Health Research (CIHR), in collaboration with C17
   Council, Canadian Cancer Society (CCS), Cancer Research Society (CRS),
   Garron Family Cancer Centre at the Hospital for Sick Children, Ontario
   Institute for Cancer Research (OICR) and Pediatric Oncology Group of
   Ontario (POGO) (grant number: TCF 118694). SM is holding a fellowship
   from the Fonds de la Recherche du Quebec-Sante (FRQ-S); PL is holding a
   fellowship from the Fonds de la Recherche du Quebec-Sante (FRQ-S); VT
   received a Canderel fellowship from the Institut du cancer de Montreal
   (ICM); FR holds a FRQ-S junior II career awards (33070) and received
   support from the ICM for this project; GL is a Research Scholar of the
   Fonds de recherche Quebec-Sante; VM was funded by a Transition grant
   from the Cole Foundation. The sponsors had no involvement in study
   design; in the collection, analysis and interpretation of data; in the
   writing of the report; and in the decision to submit the article for
   publication.
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NR 127
TC 17
Z9 21
U1 0
U2 9
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD DEC 9
PY 2020
VL 10
IS 1
AR 21507
DI 10.1038/s41598-020-78493-x
PG 15
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Science & Technology - Other Topics
GA PT9UA
UT WOS:000608953600016
PM 33299020
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Senaphan, K
   Sangartit, W
   Pakdeechote, P
   Kukongviriyapan, V
   Pannangpetch, P
   Thawornchinsombut, S
   Greenwald, SE
   Kukongviriyapan, U
AF Senaphan, Ketmanee
   Sangartit, Weerapon
   Pakdeechote, Poungrat
   Kukongviriyapan, Veerapol
   Pannangpetch, Patchareewan
   Thawornchinsombut, Supawan
   Greenwald, Stephen E.
   Kukongviriyapan, Upa
TI Rice bran protein hydrolysates reduce arterial stiffening, vascular
   remodeling and oxidative stress in rats fed a high-carbohydrate and
   high-fat diet
SO EUROPEAN JOURNAL OF NUTRITION
LA English
DT Article
DE Arterial stiffness; High-carbohydrate and high-fat diet; Metabolic
   syndrome; Rice bran protein hydrolysates; Oxidative stress; Vascular
   remodeling
ID PULSE-WAVE VELOCITY; METABOLIC SYNDROME; MATRIX METALLOPROTEINASES;
   ENDOTHELIAL FUNCTION; INSULIN-RESISTANCE; CARDIOVASCULAR RISK;
   ANGIOTENSIN-II; FERULIC ACID; ANTIOXIDANT; STIFFNESS
AB Purpose Rice bran protein hydrolysates (RBPH) contain highly nutritional proteins and antioxidant compounds which show benefits against metabolic syndrome (MetS). Increased arterial stiffness and the components of MetS have been shown to be associated with an increased risk of cardiovascular disease. This study aimed to investigate whether RBPH could alleviate the metabolic disorders, arterial stiffening, vascular remodeling, and oxidative stress in rats fed a high-carbohydrate and high-fat (HCHF) diet.
   Methods Male Sprague-Dawley rats were fed either a standard chow and tap water or a HCHF diet and 15 % fructose solution for 16 weeks. HCHF rats were treated orally with RBPH (250 or 500 mg/kg/day) for the final 6 weeks of the experimental period.
   Results Rats fed with HCHF diet had hyperglycemia, insulin resistance, dyslipidemia, hypertension, increased aortic pulse wave velocity, aortic wall hypertrophy and vascular remodeling with increased MMP-2 and MMP-9 expression. RBPH supplementation significantly alleviated these alterations (P < 0.05). Moreover, RBPH reduced the levels of angiotensin-converting enzyme (ACE) and tumor necrosis factor-alpha in plasma. Oxidative stress was also alleviated after RBPH treatment by decreasing plasma malondialdehyde, reducing superoxide production and suppressing p47(phox) NADPH oxidase expression in the vascular tissues of HCHF rats. RBPH increased plasma nitrate/nitrite level and up-regulated eNOS expression in the aortas of HCHF-diet-fed rats, indicating that RBPH increased NO production.
   Conclusion RBPH mitigate the deleterious effects of HCHF through potential mechanisms involving enhanced NO bioavailability, anti-ACE, anti-inflammatory and antioxidant properties. RBPH could be used as dietary supplements to minimize oxidative stress and vascular alterations triggered by MetS.
C1 [Senaphan, Ketmanee; Sangartit, Weerapon; Pakdeechote, Poungrat; Kukongviriyapan, Upa] Khon Kaen Univ, Fac Med, Dept Physiol, Khon Kaen 40002, Thailand.
   [Kukongviriyapan, Veerapol; Pannangpetch, Patchareewan] Khon Kaen Univ, Fac Med, Dept Pharmacol, Khon Kaen 40002, Thailand.
   [Thawornchinsombut, Supawan] Khon Kaen Univ, Fac Technol, Dept Food Technol, Khon Kaen 40002, Thailand.
   [Greenwald, Stephen E.] Queen Mary Univ London, Barts & London Sch Med & Dent, Blizard Inst, London E1 2ES, England.
C3 Khon Kaen University; Khon Kaen University; Khon Kaen University;
   University of London; Queen Mary University London
RP Kukongviriyapan, U (corresponding author), Khon Kaen Univ, Fac Med, Dept Physiol, Khon Kaen 40002, Thailand.
EM upa_ku@kku.ac.th
RI Thawornchinsombut, Supawan/AAJ-5451-2020; Greenwald, Stephen/C-6928-2012
OI Greenwald, Stephen/0000-0002-8471-7070; Sangartit,
   Weerapon/0000-0002-5058-2294; thawornchinsombut,
   supawan/0000-0003-1204-859X
FU Faculty of Medicine, Khon Kaen University; Agricultural Research
   Development Agency; National Research Council of Thailand; Thailand
   Research Fund; Royal Golden Jubilee PhD Program, the Thailand Research
   Fund [PHD/0048/2553]
FX This study was supported by grants from the Faculty of Medicine, Khon
   Kaen University, the Agricultural Research Development Agency, the
   National Research Council of Thailand and the Thailand Research Fund.
   Ketmanee Senaphan was supported by a scholarship (PHD/0048/2553) from
   the Royal Golden Jubilee PhD Program, the Thailand Research Fund.
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NR 56
TC 30
Z9 33
U1 3
U2 47
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1436-6207
EI 1436-6215
J9 EUR J NUTR
JI Eur. J. Nutr.
PD FEB
PY 2018
VL 57
IS 1
BP 219
EP 230
DI 10.1007/s00394-016-1311-0
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA FX0KU
UT WOS:000425733500017
PM 27660232
DA 2025-06-11
ER

PT J
AU Schmidt, B
   Bosch, JA
   Jarczok, MN
   Herr, RM
   Loerbroks, A
   van Vianen, AEM
   Fischer, JE
AF Schmidt, Burkhard
   Bosch, Jos A.
   Jarczok, Marc N.
   Herr, Raphael M.
   Loerbroks, Adrian
   van Vianen, Annelies E. M.
   Fischer, Joachim E.
TI Effort-reward imbalance is associated with the metabolic syndrome -
   Findings from the Mannheim Industrial Cohort Study (MICS)
SO INTERNATIONAL JOURNAL OF CARDIOLOGY
LA English
DT Article
DE Metabolic syndrome; Job stress; Effort; Reward; Effort-reward imbalance;
   Workplace
ID CORONARY-HEART-DISEASE; WORK STRESS; RISK-FACTORS;
   CARDIOVASCULAR-DISEASE; PSYCHOSOCIAL STRESS; RATE-VARIABILITY;
   DEMAND-CONTROL; JOB STRAIN; FOLLOW-UP; MORTALITY
AB Background/objectives: Job stress is a predictor of cardiovascular disease incidence andmortality and the metabolic syndrome (MetS) represents one of the key pathways potentially underlying those associations. Effort-reward imbalance (ERI) represents one of the most influential theoretical work stress models, but evidence on its relationship with MetS remains sparse and with only limited generalizability. We therefore aimed to determine this association in a large occupational sample with different occupational groups.
   Methods: The present study used cross-sectional data from an industrial sample in Germany (n = 4141). ERI was assessed by a validated 10-item questionnaire. MetS was defined according to a joined interim statement of six expert associations involved with MetS, stating that three out of five risk factors (raised blood pressure, elevated triglycerides, low high density lipoprotein, raised fasting glucose and central obesity) qualify a patient for MetS. Multivariable associations of ERI, and its subcomponents "effort" and " reward", with MetS were estimated by logistic regression-based multivariate odds ratios (ORs) with 95% confidence intervals (CIs).
   Results: ERI (continuous z-score) was positively associated with MetS (zERI: OR = 1.14, 95% CI = 1.03-1.26). The association was more prominent in males (zERI: OR 1.20, 95% CI = 1.07-1.33) and in younger employees (age 18-49 zERI: OR = 1.24, 95% CI = 1.09-1.40). Analysis of the ERI subcomponents yielded weak associations of both effort (zEffort: OR = 1.12, 95% CI = 1.00-1.25) and reward (zReward: OR= 0.92, 95% CI = 0.84-1.00) with MetS.
   Conclusions: ERI is associated with increased occurrence of MetS, in particular among younger men. Further longitudinal studies are needed to determine the temporal relation of these associations. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
C1 [Schmidt, Burkhard; Bosch, Jos A.; Jarczok, Marc N.; Herr, Raphael M.; Loerbroks, Adrian; Fischer, Joachim E.] Heidelberg Univ, Med Fac Mannheim, Mannheim Inst Publ Hlth Social & Prevent Med, D-68167 Mannheim, Germany.
   [Bosch, Jos A.; Herr, Raphael M.] Univ Amsterdam, Dept Clin Psychol, NL-1018 WB Amsterdam, Netherlands.
   [Loerbroks, Adrian] Univ Dusseldorf, Fac Med, Ctr Hlth & Soc, Inst Occupat & Social Med, Dusseldorf, Germany.
   [Schmidt, Burkhard; van Vianen, Annelies E. M.] Univ Amsterdam, Dept Work & Org Psychol, Amsterdam, Netherlands.
C3 Ruprecht Karls University Heidelberg; University of Amsterdam; Heinrich
   Heine University Dusseldorf; University of Amsterdam
RP Schmidt, B (corresponding author), Heidelberg Univ, Med Fac Mannheim, Mannheim Inst Publ Hlth Social & Prevent Med, Ludolf Krehl Str 7-11, D-68167 Mannheim, Germany.
EM burkhard.schmidt@medma.uni-heidelberg.de
RI van Vianen, Annelies/KLC-2137-2024; Loerbroks, Adrian/IZP-5772-2023;
   Herr, Raphael/GYU-5115-2022; Bosch, Jos/AAC-9408-2019; Jarczok, Marc
   N./A-2383-2014; Schmidt, Burkhard/HKP-1156-2023
OI Jarczok, Marc N./0000-0002-6055-385X; Schmidt,
   Burkhard/0000-0003-2120-8014; Schmidt, Burkhard/0000-0001-7394-2742; van
   Vianen, Annelies/0000-0002-3931-0394
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NR 44
TC 27
Z9 31
U1 0
U2 22
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0167-5273
EI 1874-1754
J9 INT J CARDIOL
JI Int. J. Cardiol.
PD JAN 15
PY 2015
VL 178
BP 24
EP 28
DI 10.1016/j.ijcard.2014.10.115
PG 5
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Cardiovascular System & Cardiology
GA AU6EY
UT WOS:000345697300009
PM 25464211
OA Bronze
DA 2025-06-11
ER

PT J
AU Nisha, VM
   Priyanka, A
   Anusree, SS
   Raghu, KG
AF Nisha, V. M.
   Priyanka, A.
   Anusree, S. S.
   Raghu, K. G.
TI (-)-Hydroxycitric acid attenuates endoplasmic reticulum stress-mediated
   alterations in 3T3-L1 adipocytes by protecting mitochondria and
   downregulating inflammatory markers
SO FREE RADICAL RESEARCH
LA English
DT Article
DE adipokines; antioxidant enzymes; heme oxygenase; mitochondria; 3T3-L1
ID SUPEROXIDE-DISMUTASE; OXIDATIVE STRESS; BODY-WEIGHT; ER STRESS;
   OVEREXPRESSION; PROTEIN; TISSUE; DEATH; CELLS; GAMMA
AB Endoplasmic reticulum (ER) stress is an emerging potential therapeutic target for metabolic syndrome due to its role in synthesis, secretion, and folding of proteins. It leads to an increased production of reactive oxygen species (ROS) which, along with mitochondrial dysfunction and reduced antioxidant defense, causes chronic cell injury. The present investigation aims to observe the alterations in adipocytes due to ER stress and the protective effect of hydroxycitric acid (HCA), a bioactive from Garcinia species, to develop the same as a nutraceutical. ER stress was induced in mature 3T3-L1 adipocytes by treating them with tunicamycin (2 mu g/ml) for 18 h. Alterations in cell viability, innate antioxidant system (superoxide dismutase, glutathione peroxidase, and glutathione reductase), mitochondria (membrane potential, biogenesis, and transition pore opening), and inflammatory cytokines (tumor necrosis factor, monocyte chemoattractant protein, interferon-gamma, interleukin (IL)-10, IL-6, and IL-1 beta) during ER stress, and co-treatment with HCA were analyzed. Endocrine function of adipocytes was also assessed by measuring adiponectin and leptin secretion levels. HCA protected the cells from ER stress by improving the antioxidant status and mitochondrial functions. The results validate nutraceutical properties of the edible bioactive, commonly used for culinary purpose. A more detailed study on the mechanism of action of HCA is required for developing it as a therapeutic agent for metabolic syndrome.
C1 [Nisha, V. M.; Priyanka, A.; Anusree, S. S.; Raghu, K. G.] CSIR, Natl Inst Interdisciplinary Sci & Technol, Agroproc & Nat Prod Div, Thiruvananthapuram 695019, Kerala, India.
C3 Council of Scientific & Industrial Research (CSIR) - India; CSIR -
   National Institute Interdisciplinary Science & Technology (NIIST)
RP Raghu, KG (corresponding author), CSIR, Natl Inst Interdisciplinary Sci & Technol, Agroproc & Nat Prod Div, Thiruvananthapuram 695019, Kerala, India.
EM raghukgopal2009@gmail.com
RI Raghu, K/AAT-8042-2021
FU Council for Scientific and Industrial Research, Govt. of India; CSIR
   12th 5-year plan project [NaPAHA-CSC-0130]
FX We thank the Council for Scientific and Industrial Research, Govt. of
   India, for financial assistance in the form of research fellowship for
   NVM. We are also thankful to the CSIR 12th 5-year plan project
   "NaPAHA-CSC-0130" for financial support. We thank the Director,
   CSIR-NIIST and Head, Agroprocessing and Natural Products Division, for
   providing necessary facilities.
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NR 49
TC 9
Z9 11
U1 1
U2 20
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1071-5762
EI 1029-2470
J9 FREE RADICAL RES
JI Free Radic. Res.
PD NOV
PY 2014
VL 48
IS 11
BP 1386
EP 1396
DI 10.3109/10715762.2014.959514
PG 11
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA AQ4LC
UT WOS:000342767500012
PM 25175938
DA 2025-06-11
ER

PT J
AU Painold, A
   Mörkl, S
   Kashofer, K
   Halwachs, B
   Dalkner, N
   Bengesser, S
   Birner, A
   Fellendorf, F
   Platzer, M
   Queissner, R
   Schütze, G
   Schwarz, MJ
   Moll, N
   Holzer, P
   Holl, AK
   Kapfhammer, HP
   Gorkiewicz, G
   Reininghaus, EZ
AF Painold, Annamaria
   Moerkl, Sabrina
   Kashofer, Karl
   Halwachs, Bettina
   Dalkner, Nina
   Bengesser, Susanne
   Birner, Armin
   Fellendorf, Frederike
   Platzer, Martina
   Queissner, Robert
   Schuetze, Gregor
   Schwarz, Markus J.
   Moll, Natalie
   Holzer, Peter
   Holl, Anna K.
   Kapfhammer, Hans-Peter
   Gorkiewicz, Gregor
   Reininghaus, Eva Z.
TI A step ahead: Exploring the gut microbiota in inpatients with bipolar
   disorder during a depressive episode
SO BIPOLAR DISORDERS
LA English
DT Article
DE 16S rRNA gene; bipolar disorder; diversity; gut-brain axis; gut
   microbiota; illness duration; inflammation; metabolic syndrome;
   oxidative stress; tryptophan
ID BODY-MASS INDEX; OXIDATIVE STRESS; ANTIOXIDATIVE DEFENSE; BRAIN;
   OBESITY; TRYPTOPHAN; OVERWEIGHT; CYTOKINES; EUTHYMIA; AXIS
AB Objectives There is evidence that the gut microbiota plays a major role in the pathogenesis of diseases of the central nervous system through the gut-brain axis. The aim of the present study was to analyze gut microbiota composition in bipolar disorder (BD) and its relation to inflammation, serum lipids, oxidative stress, tryptophan (TRP)/kynurenine (KYN) levels, anthropometric measurements and parameters of metabolic syndrome. Further, microbial community differences of individuals with BD compared with healthy controls (HC) were explored. Methods In this cross-sectional study, we performed 16S rRNA gene sequencing of stool samples from 32 BD individuals and 10 HC. Laboratory parameters included inflammatory markers, serum lipids, KYN, oxidative stress and anthropometric measures. Microbial community analysis and correlation to clinical parameters was performed with QIIME, differential abundance analysis of taxa encompassed linear discriminant analysis effect size (LEfSe). Results We found a negative correlation between microbial alpha-diversity and illness duration in BD (R = -0.408, P = 0.021). Furthermore, we identified bacterial clades associated with inflammatory status, serum lipids, TRP, depressive symptoms, oxidative stress, anthropometrics and metabolic syndrome in individuals with BD. LEfSe identified the phylum Actinobacteria (LDA= 4.82, P = 0.007) and the class Coriobacteria (LDA= 4.75, P = 0.010) as significantly more abundant in BD when compared with HC, and Ruminococcaceae (LDA= 4.59, P = 0.018) and Faecalibacterium (LDA= 4.09, P = 0.039) as more abundant in HC when compared with BD. Conclusions The present findings suggest that causes and/or consequences of BD may also lie outside the brain. Exploratory research of the gut microbiota in affective disorders like BD may identify previously unknown underlying causes, and offer new research and therapeutic approaches to mood disorders.
C1 [Painold, Annamaria; Moerkl, Sabrina; Dalkner, Nina; Bengesser, Susanne; Birner, Armin; Fellendorf, Frederike; Platzer, Martina; Queissner, Robert; Holl, Anna K.; Kapfhammer, Hans-Peter; Reininghaus, Eva Z.] Med Univ Graz, Dept Psychiat & Psychotherapeut Med, Auenbruggerpl 31, A-8036 Graz, Austria.
   [Kashofer, Karl; Halwachs, Bettina; Gorkiewicz, Gregor] Med Univ Graz, Inst Pathol, Graz, Austria.
   [Schuetze, Gregor; Schwarz, Markus J.; Moll, Natalie] Med Ctr Munich Univ LMU, Inst Lab Med, Munich, Germany.
   [Holzer, Peter] Med Univ Graz, Inst Expt & Clin Pharmacol, Graz, Austria.
C3 Medical University of Graz; Medical University of Graz; University of
   Munich; Medical University of Graz
RP Painold, A (corresponding author), Med Univ Graz, Dept Psychiat & Psychotherapeut Med, Auenbruggerpl 31, A-8036 Graz, Austria.
EM annamaria.painold@medunigraz.at
RI Halwachs, Bettina/AAD-4347-2019; Gorkiewicz, Gregor/ABF-1602-2021;
   Holzer, Peter/F-7578-2011
OI Schwarz, Markus/0000-0001-8895-3743; Gorkiewicz,
   Gregor/0000-0003-1149-4782; Holzer, Peter/0000-0002-5754-395X;
   Reininghaus, Eva/0000-0001-5964-4087; Fellendorf,
   Frederike/0000-0001-7215-3848; Dalkner, Nina/0000-0001-7716-3674
FU Stadt Graz [A16 - 28180/2009]
FX Stadt Graz, Grant/Award Number: A16 - 28180/2009
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NR 61
TC 144
Z9 153
U1 8
U2 94
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1398-5647
EI 1399-5618
J9 BIPOLAR DISORD
JI Bipolar Disord.
PD FEB
PY 2019
VL 21
IS 1
BP 40
EP 49
DI 10.1111/bdi.12682
PG 10
WC Clinical Neurology; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Psychiatry
GA HM9GL
UT WOS:000459791000006
PM 30051546
OA hybrid, Green Published
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Schneider, MP
   Schlaich, MP
   Harazny, JM
   Raff, U
   Ritt, M
   Ott, C
   Schmieder, RE
AF Schneider, Markus P.
   Schlaich, Markus P.
   Harazny, Joanna M.
   Raff, Ulrike
   Ritt, Martin
   Ott, Christian
   Schmieder, Roland E.
TI Folic Acid Treatment Normalizes NOS-Dependence of Vascular Tone in the
   Metabolic Syndrome
SO OBESITY
LA English
DT Article
ID NITRIC-OXIDE SYNTHASE; ENHANCES ENDOTHELIAL FUNCTION; RETINAL
   MICROVASCULAR SIGNS; RANDOMIZED CONTROLLED-TRIAL; C-REACTIVE PROTEIN;
   CARDIOVASCULAR-DISEASE; DIABETIC-NEPHROPATHY; OXIDATIVE STRESS;
   GLOMERULAR HYPERFILTRATION; HYPERTENSIVE PATIENTS
AB Obese subjects with the metabolic syndrome (MS+) are more prone to microvascular complications than obese subjects without the metabolic syndrome (MS-). Excessive vascular nitric oxide (NO) production has been demonstrated in MS+ compared to MS-, perhaps driven by increased inflammation or oxidative stress. We tested whether in MS+, folic acid (FA) treatment could normalize NO synthase (NOS)- dependence of vascular tone in the retina and kidney. MS+ (n = 49) and MS- (n = 26) subjects were included in a randomized, double-blind, crossover trial. After 4- weeks' treatment with placebo or FA (5 mg/day), several cytokines (C-reactive protein (CRP), interleukin-1 beta, adiponectin), and markers of oxidative stress (glutathione/oxidized glutathione (GSH/GSSG) ratio, total antioxidant capacity (TAC)) were determined. NOS-dependence of retinal and renal vascular tone was assessed by retinal scanning laser Doppler flowmetry and renal clearance technique, respectively. FA had no effect on cytokine levels, but increased GSH/GSSG ratio overall (36 +/- 76 vs. 102 +/- 200, P = 0.04), indicative of a reduction in oxidative stress. In MS+, treatment with FA reduced NOS-dependence of retinal and renal vascular tone compared to placebo (P = 0.03 and P = 0.04, respectively). FA had no effect in MS-. After treatment with FA, NOS-dependence of retinal and renal vascular tone was similar between MS+ and MS-. Retinal and renal vascular tone in MS+ subjects is characterized by increased dependence on NOS. NOS-dependence in MS+ could be corrected by FA treatment to levels not dissimilar in MS-, and this was associated with a reduction in oxidative stress. Future trials should test whether these effects translate into a reduction of microvascular complications.
C1 [Schneider, Markus P.; Schlaich, Markus P.; Harazny, Joanna M.; Raff, Ulrike; Ritt, Martin; Ott, Christian; Schmieder, Roland E.] Univ Erlangen Nurnberg, Dept Nephrol & Hypertens, Erlangen, Germany.
   [Schneider, Markus P.] Univ Glasgow, BHF Glasgow Cardiovasc Res Ctr, Div Cardiovasc & Med Sci, Glasgow, Lanark, Scotland.
   [Schlaich, Markus P.] Baker IDI Heart & Diabet Inst, Neurovasc Hypertens & Kidney Dis Lab, Melbourne, Vic, Australia.
C3 University of Erlangen Nuremberg; University of Glasgow; Baker Heart and
   Diabetes Institute
RP Schneider, MP (corresponding author), Univ Erlangen Nurnberg, Dept Nephrol & Hypertens, Erlangen, Germany.
EM m.schneider@clinmed.gla.ac.uk
RI Harazna, Joanna/AAV-1502-2021; Schneider, Markus/AAT-4094-2020;
   Schlaich, Markus/E-7468-2010
OI Schlaich, Markus/0000-0002-1765-0195; Harazna, Joanna
   Maria/0000-0003-0124-0543; Schneider, Markus/0000-0002-5265-8088
FU Deutsche Forschungsgemeinschaft [SFB 423, TP B5]; NHMRC
FX This study was funded by grants from the Deutsche Forschungsgemeinschaft
   to M.P. Schlaich, M.P. Schneider, and R.E.S. (SFB 423, TP B5), by a
   Research Fellowship from the European Society of Hypertension to M. P.
   Schneider and by an NHMRC Senior Research Fellowship to M.P. Schlaich.
   The authors gratefully acknowledge the expert technical assistance of
   Ingrid Fleischmann, Dorothea Bader-Schmieder, Simone Pejkovic, Susanne
   Avendano, Ulrike Heinritz, Petra Schatz, and Ortrun Alter.
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NR 66
TC 10
Z9 10
U1 0
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1930-7381
EI 1930-739X
J9 OBESITY
JI Obesity
PD MAY
PY 2011
VL 19
IS 5
BP 960
EP 967
DI 10.1038/oby.2010.210
PG 8
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 755LS
UT WOS:000289933300013
PM 20864946
OA Bronze
DA 2025-06-11
ER

PT J
AU Avogaro, A
AF Avogaro, A.
TI Insulin resistance: trigger or concomitant factor in the metabolic
   syndrome
SO PANMINERVA MEDICA
LA English
DT Review
DE metabolic syndrome; risk factors; insulin resistance
ID ENDOPLASMIC-RETICULUM STRESS; ADIPOSE-TISSUE; CARDIOVASCULAR-DISEASE;
   OBESITY; INFLAMMATION; PREVALENCE; ACTIVATION; EXPRESSION; PROTEIN;
   KINASE
AB The metabolic syndrome (MS) is a cluster of metabolic abnormalities with insulin resistance as a major characteristic. The main adverse consequence of the MS is cardiovascular disease (CVD). Complex, mutually reinforcing interactions between obesity and insulin resistance largely account for the pathogenesis of MS. Central pathophysiologic features include: insulin resistance, atherogenic dyslipidemia, chiefly present as low HDL-C together with increases in triglycerides and small dense, low density lipoprotein particles, hypertension, a proinflammatory state, with increases in acute-phase reactants, and a prothrombotic state. Although lifestyle and overeating seem to be the triggering pathogenic factors, genetic elements are also involved in the pathogenesis of MS. When present, insulin resistance results in impaired insulin action in insulin-sensitive tissues such as muscle, fat, and liver. Insulin resistance results in abnormalities of glucose metabolism, with reduced peripheral disposal of glucose in muscle and increased hepatic glucose output in the fasting state. But, most importantly, the progressively increasing concentration in circulating glucose leads to various abnormalities in insulin secretion. Elevated insulin levels themselves are atherogenic by inducing an oxidative stress and by stimulating sympathetic-nerve activity. Ectopic fat deposition, stress, proinflammatory state, and a maladaptive response of innate immunity may together concur to the development of the MS. When this condition is acknowledged, substantial modification of life style and correction of each single risk factor should be pursued without uncertainties and without hierarchical approach; this means that each risk factor should be treated and brought to target.
C1 Univ Padua, Dept Clin & Expt Med, Padua, Italy.
C3 University of Padua
RP Avogaro, A (corresponding author), Policlin, Dipartimento Med Sperimentale, Via Giustiniani 2, I-35128 Padua, Italy.
EM angelo.avogaro@unipd.it
RI Avogaro, Angelo/S-3808-2016
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NR 49
TC 15
Z9 16
U1 0
U2 2
PU EDIZIONI MINERVA MEDICA
PI TURIN
PA CORSO BRAMANTE 83-85 INT JOURNALS DEPT., 10126 TURIN, ITALY
SN 0031-0808
EI 1827-1898
J9 PANMINERVA MED
JI Panminerva Medica
PD MAR
PY 2006
VL 48
IS 1
BP 3
EP 12
PG 10
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 051HA
UT WOS:000238151000002
PM 16633326
DA 2025-06-11
ER

PT J
AU Bañuls, C
   Rovira-Llopis, S
   de Marañon, AM
   Veses, S
   Jover, A
   Gomez, M
   Rocha, M
   Hernandez-Mijares, A
   Victor, VM
AF Banuls, Celia
   Rovira-Llopis, Susana
   Martinez de Maranon, Aranzazu
   Veses, Silvia
   Jover, Ana
   Gomez, Marcelino
   Rocha, Milagros
   Hernandez-Mijares, Antonio
   Victor, Victor M.
TI Metabolic syndrome enhances endoplasmic reticulum, oxidative stress and
   leukocyte-endothelium interactions in PCOS
SO METABOLISM-CLINICAL AND EXPERIMENTAL
LA English
DT Article
DE PCOS; Metabolic syndrome; Endoplasmic reticulum stress; Endothelial
   function; Inflammation
ID POLYCYSTIC-OVARY-SYNDROME; UNFOLDED PROTEIN RESPONSE; IN-VITRO MODEL;
   INSULIN-RESISTANCE; MESSENGER-RNA; ER STRESS; INFLAMMATION; EXPRESSION;
   OBESITY; WOMEN
AB Objective. Polycystic ovary syndrome (PCOS) is associated with insulin resistance, which can lead to metabolic syndrome (MetS). Oxidative stress and leukocyte-endothelium interactions are related to PCOS. Our aim was to evaluate whether the presence of MetS in PCOS patients can influence endoplasmic reticulum (ER) and oxidative stress and leukocyte endothelium interactions.
   Material and Methods. This was a prospective controlled study conducted in an academic medical center. The study population consisted of 148 PCOS women (116 without/32 with MetS) and 112 control subjects (87 without / 25 with MetS). Metabolic parameters, reactive oxygen species (ROS) production, ER stress markers (GRP78, sXBP1, ATF6), leukocyte-endothelium interactions, adhesion molecules (VCAM-1, ICAM-1, E-Selectin), TNF-alpha and IL-6 were determined.
   Results. Total ROS, inflammatory parameters and adhesion molecules were enhanced in the presence of MetS (p < 0.05), and the PCOS + MetS group showed higher levels of IL-6 and ICAM-1 than controls (p < 0.05). Increased adhesion and leukocyte rolling flux were observed in PCOS and PCOS + MetS groups vs their respective controls (p < 0.05). GRP78 protein expression was higher in the PCOS groups (p < 0.05 vs controls) and sXBP1 was associated with the presence of MetS (p < 0.05 vs controls without MetS). Furthermore, PCOS + MetS patients exhibited higher GRP78 and ATF6 levels than controls and PCOS patients without MetS (p < 0.05). In PCOS women, HOMA-IR was positively correlated with ICAM-1 (r = 0.501; p < 0.01), ROS (r = 0.604; p < 0.01), rolling flux (r = 0.455;p < 0.05) and GRP78 (r = 0.574; p < 0.001).
   Conclusion. Our findings support the hypothesis of an association between altered metabolic status, increased ROS production, ER stress and leukocyte-endothelium interactions in PCOS, all of which are related to vascular complications. (C) 2017 Elsevier Inc. All rights reserved.
C1 [Banuls, Celia; Rovira-Llopis, Susana; Martinez de Maranon, Aranzazu; Veses, Silvia; Jover, Ana; Gomez, Marcelino; Rocha, Milagros; Hernandez-Mijares, Antonio; Victor, Victor M.] Univ Hosp Doctor Peset, Fdn Promot Hlth & Biomed Res Valencian Reg FISABI, Serv Endocrinol, Valencia, Spain.
   [Banuls, Celia; Rovira-Llopis, Susana; Hernandez-Mijares, Antonio] Univ Valencia, Inst Hlth Res INCLIVA, Valencia, Spain.
   [Rocha, Milagros; Victor, Victor M.] Univ Valencia, CIBERehd, Dept Pharmacol & Physiol, Valencia, Spain.
   [Hernandez-Mijares, Antonio] Univ Valencia, Dept Med, Valencia, Spain.
   [Victor, Victor M.] Univ Valencia, Dept Physiol, Valencia, Spain.
C3 University of Valencia; University of Valencia; CIBER - Centro de
   Investigacion Biomedica en Red; CIBEREHD; University of Valencia;
   University of Valencia
RP Hernandez-Mijares, A; Victor, VM (corresponding author), Univ Hosp Doctor Peset, Avda Gaspar Aguilar 90, Valencia 46017, Spain.
EM hernandez_antmij@gva.es; Victor.Victor@uv.es
RI victor, victor/Q-4843-2019; Banuls, Celia/H-7359-2017; Rocha,
   Milagros/I-4987-2015; Martinez de Maranon Peris, Aranzazu/H-4399-2017;
   Rovira-Llopis, Susana/AAX-8666-2021
OI Banuls, Celia/0000-0001-8077-7642; Rocha, Milagros/0000-0003-2923-6546;
   VICTOR, VICTOR/0000-0002-3027-3945; Martinez de Maranon Peris,
   Aranzazu/0000-0002-4153-0396; Rovira-Llopis, Susana/0000-0002-8476-5128
FU Carlos III Health Institute [PI13/1025, PI15/1424, PI16/00301,
   PI16/01083, CIBERehd CB06/04/0071, CES10/030, CPII16/00037, CD14/00043];
   Foundation for the Promotion of Health and Biomedical Research in the
   Valencian Region (FISABIO) [UGP15-193, UGP-15-220]; Ministry of
   Education of the Valencian Regional Government [PROMETEOII 2014/035,
   GV/2016/169]; European Regional Development Fund (ERDF); Ministry of
   Health of the Valencian Regional Government; Spanish Ministry of Economy
   and Competitiveness [FJCI-2015-25,040]
FX This study was financed by grants PI13/1025, PI15/1424, PI16/00301,
   PI16/01083 and CIBERehd CB06/04/0071 by Carlos III Health Institute,
   UGP15-193 and UGP-15-220 by Foundation for the Promotion of Health and
   Biomedical Research in the Valencian Region (FISABIO), PROMETEOII
   2014/035 and GV/2016/169 by the Ministry of Education of the Valencian
   Regional Government and the European Regional Development Fund (ERDF "A
   way to build Europe"). V.M.V. and M.R. are recipients of contracts from
   the Ministry of Health of the Valencian Regional Government and Carlos
   III Health Institute (CES10/030 and CPII16/00037, respectively). C.B. is
   recipient of a Sara Borrell contract from Carlos III Health Institute
   (CD14/00043). S.R-LL. is recipient of a Juan de la Cierva contract from
   Spanish Ministry of Economy and Competitiveness (FJCI-2015-25,040).
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NR 41
TC 68
Z9 72
U1 1
U2 24
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0026-0495
EI 1532-8600
J9 METABOLISM
JI Metab.-Clin. Exp.
PD JUN
PY 2017
VL 71
BP 153
EP 162
DI 10.1016/j.metabol.2017.02.012
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA EW5YW
UT WOS:000402583400016
PM 28521868
DA 2025-06-11
ER

PT J
AU Arranz, B
   Sanchez-Autet, M
   San, L
   Safont, G
   De la Puente-Tomás, L
   Hernandeza, C
   Bogas, JL
   García-Portilla, MP
AF Arranz, Belen
   Sanchez-Autet, Monica
   San, Luis
   Safont, Gemma
   De la Puente-Tomas, Lorena
   Hernandez, Carla
   Luis Bogas, Jose
   Paz Garcia-Portilla, Maria
TI Are plasma 25-hydroxyvitamin D and retinol levels and one-carbon
   metabolism related to metabolic syndrome in patients with a severe
   mental disorder?
SO PSYCHIATRY RESEARCH
LA English
DT Article
DE Biomarkers; Vitamins; Homocysteine; HOMA; QUICKI; Bipolar Disorder;
   Schizophrenia
ID VITAMIN-D INSUFFICIENCY; BIPOLAR DISORDER; INSULIN-RESISTANCE;
   1ST-EPISODE SCHIZOPHRENIA; CARDIOVASCULAR-DISEASE; FOLATE LEVELS;
   DEPRESSIVE SYMPTOMS; HOMOCYSTEINE LEVELS; ANTIOXIDANT STATUS;
   BINDING-PROTEIN
AB There is a scarcity of studies assessing the influence of biomarkers in metabolic syndrome in psychiatric patients. Our aim was to correlate serum or plasma levels of 25-hydroxyvitamin D (25-OH-VD), retinol, vitamin B12 (VB12), folate and homocysteine (Hcy), with the metabolic status, in a sample of 289 outpatients with Schizophrenia or Bipolar Disorder. Logistic regression and multiple linear regressions were performed to assess the ability of biomarkers to predict the presence of MetS, the number of risk factors for MetS, and insulin resistance indexes (HOMA and QUICKI). Regarding the association between biomarkers and the QUICKI index, the model explained 6.8% of the variance, with folate and 25-OH-VD levels contributing significantly to the model. The model predicting the number of MetS risk factors was significant and explained 21.7% of the variance, being 25-OH-VD and retinol the statistically significant factors. As for the impact of biomarkers on MetS, the model was statistically significant, being 25-OH-VD and retinol levels the significant factors. We report for the first time an association between MetS and both low 25-OH-VD and high retinol concentrations. Inflammation-related biomarkers may help identify patients with a high risk of MetS who might benefit from healthy lifestyle counselling and early intervention.
C1 [Arranz, Belen; Sanchez-Autet, Monica; San, Luis; Hernandez, Carla; Luis Bogas, Jose] Parc Sanitari St Joan Deu, Via Laietana 19, Barcelona 08003, Spain.
   [Safont, Gemma] Hosp Univ Mutua Terrassa, Barcelona, Spain.
   [De la Puente-Tomas, Lorena; Paz Garcia-Portilla, Maria] Univ Oviedo, Dept Psychiat, Oviedo, Spain.
   [Arranz, Belen; San, Luis; Safont, Gemma; De la Puente-Tomas, Lorena; Paz Garcia-Portilla, Maria] Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain.
   [Sanchez-Autet, Monica; San, Luis; Safont, Gemma] Univ Barcelona, Barcelona, Spain.
C3 Hospital Universitario Mutua Terrassa; University of Oviedo; CIBER -
   Centro de Investigacion Biomedica en Red; CIBERSAM; University of
   Barcelona
RP Sanchez-Autet, M (corresponding author), Parc Sanitari St Joan Deu, Via Laietana 19, Barcelona 08003, Spain.
EM ms.autet@pssjd.org
RI Sanchez, Monica/ABI-6419-2020; de la Fuente-Tomás, Lorena/O-6300-2018;
   Garcia-Portilla, Paz/AAC-8272-2020
OI Garcia-Portilla, Paz/0000-0003-3643-1622; de la Fuente-Tomas,
   Lorena/0000-0001-8220-5007; Safont, Gemma/0000-0001-5122-9161;
   Sanchez-Autet, Monica/0000-0003-1349-9042; Arranz,
   Belen/0000-0003-3927-8803
FU Instituto de Salud Carlos III - Fondos Europeos de Desarrollo Regional
   (FEDER) [PI11/02493, PI17/00246]
FX This study was supported by grants from the Instituto de Salud Carlos
   III - Fondos Europeos de Desarrollo Regional (FEDER) (grants PI11/02493
   and PI17/00246). The sponsors had no involvement in the study design,
   collection, analysis, and interpretation of data, in the writing of the
   report, and in the decision to submit the article for publication.
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NR 88
TC 2
Z9 3
U1 0
U2 8
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0165-1781
J9 PSYCHIAT RES
JI Psychiatry Res.
PD MAR
PY 2019
VL 273
BP 22
EP 29
DI 10.1016/j.psychres.2019.01.005
PG 8
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA HU1VH
UT WOS:000465059400004
PM 30639560
DA 2025-06-11
ER

PT J
AU Salminen, A
   Hyttinen, JMT
   Kaarniranta, K
AF Salminen, Antero
   Hyttinen, Juha M. T.
   Kaarniranta, Kai
TI AMP-activated protein kinase inhibits NF-κB signaling and inflammation:
   impact on healthspan and lifespan
SO JOURNAL OF MOLECULAR MEDICINE-JMM
LA English
DT Review
DE Aging; Diabetes; Inflammation; Metabolic syndrome; NF-kappa B; SIRT1
ID ENDOPLASMIC-RETICULUM STRESS; THIOREDOXIN-INTERACTING PROTEIN; VASCULAR
   ENDOTHELIAL-CELLS; NECROSIS-FACTOR-ALPHA; OXIDATIVE STRESS; IN-VIVO;
   METABOLIC SYNDROME; 5-AMINOIMIDAZOLE-4-CARBOXAMIDE RIBONUCLEOSIDE;
   MITOCHONDRIAL BIOGENESIS; CAENORHABDITIS-ELEGANS
AB Adenosine monophosphate-activated protein kinase (AMPK) is a crucial regulator of energy metabolic homeostasis and thus a major survival factor in a variety of metabolic stresses and also in the aging process. Metabolic syndrome is associated with a low-grade, chronic inflammation, primarily in adipose tissue. A low-level of inflammation is also present in the aging process. There are emerging results indicating that AMPK signaling can inhibit the inflammatory responses induced by the nuclear factor-kappa B (NF-kappa B) system. The NF-kappa B subunits are not direct phosphorylation targets of AMPK, but the inhibition of NF-kappa B signaling is mediated by several downstream targets of AMPK, e.g., SIRT1, PGC-1 alpha, p53, and Forkhead box O (FoxO) factors. AMPK signaling seems to enhance energy metabolism while it can repress inflammatory responses linked to chronic stress, e.g., in nutritional overload and during the aging process. AMPK can inhibit endoplasmic reticulum and oxidative stresses which are involved in metabolic disorders and the aging process. Interestingly, many target proteins of AMPK are so-called longevity factors, e. g., SIRT1, p53, and FoxOs, which not only can increase the stress resistance and extend the lifespan of many organisms but also inhibit the inflammatory responses. The activation capacity of AMPK declines in metabolic stress and with aging which could augment the metabolic diseases and accelerate the aging process. We will review the AMPK pathways involved in the inhibition of NF-kappa B signaling and suppression of inflammation. We also emphasize that the capacity of AMPK to repress inflammatory responses can have a significant impact on both healthspan and lifespan.
C1 [Salminen, Antero] Univ Eastern Finland, Inst Clin Med, Dept Neurol, Kuopio 70211, Finland.
   [Salminen, Antero] Kuopio Univ Hosp, Dept Neurol, Kuopio 70211, Finland.
   [Hyttinen, Juha M. T.; Kaarniranta, Kai] Univ Eastern Finland, Inst Clin Med, Dept Ophthalmol, Kuopio 70211, Finland.
   [Kaarniranta, Kai] Kuopio Univ Hosp, Dept Ophthalmol, Kuopio 70211, Finland.
C3 University of Eastern Finland; University of Eastern Finland; University
   of Eastern Finland Hospital; Kuopio University Hospital; University of
   Eastern Finland; Kuopio University Hospital; University of Eastern
   Finland; University of Eastern Finland Hospital
RP Salminen, A (corresponding author), Univ Eastern Finland, Inst Clin Med, Dept Neurol, POB 1627, Kuopio 70211, Finland.
EM antero.salminen@uef.fi; juha.hyttinen@uef.fi; kai.kaarniranta@uef.fi
OI Kaarniranta, Kai/0000-0003-2600-8679; Hyttinen, Juha/0000-0002-3414-4032
FU Academy of Finland; University of Eastern Finland, Kuopio, Finland
FX This study was financially supported by grants from the Academy of
   Finland and the University of Eastern Finland, Kuopio, Finland. The
   authors thank Dr. Ewen MacDonald for checking the language of the
   manuscript.
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NR 117
TC 696
Z9 757
U1 4
U2 85
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0946-2716
EI 1432-1440
J9 J MOL MED
JI J. Mol. Med.
PD JUL
PY 2011
VL 89
IS 7
BP 667
EP 676
DI 10.1007/s00109-011-0748-0
PG 10
WC Genetics & Heredity; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Genetics & Heredity; Research & Experimental Medicine
GA 804FG
UT WOS:000293639100005
PM 21431325
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Bakhtiary, A
   Yassin, Z
   Hanachi, P
   Rahmat, A
   Ahmad, Z
   Halalkhor, S
   Firouzjahi, AR
AF Bakhtiary, A.
   Yassin, Z.
   Hanachi, P.
   Rahmat, A.
   Ahmad, Z.
   Halalkhor, S.
   Firouzjahi, A. R.
TI Evaluation of the Oxidative Stress and Glycemic Control Status in
   Response to Soy in Older Women with the Metabolic Syndrome
SO IRANIAN RED CRESCENT MEDICAL JOURNAL
LA English
DT Article
DE Soy; Metabolic syndrome; Oxidative stress; Insulin resistance; Women
ID RISK-FACTORS; DENSITY-LIPOPROTEIN; INSULIN-RESISTANCE; PROTEIN-INTAKE;
   DIETARY SOY; ISOFLAVONES; SUPPLEMENTATION; INDEXES; MARKERS;
   PHYTOESTROGENS
AB Background: Little evidence exists about the effects of soy on glycemic control and oxidative stress in elderly women with metabolic syndrome (MetS). The aim of this study was to ascertain the effects of soy on fasting blood glucose (FBG), insulin, homeostasis model of assessment insulin resistance (HOMA-IR), malondialdehyde (MDA) and total antioxidant capacity (TAC) on these individuals.
   Methods: A 12-week randomized clinical trial was conducted on 75 women between 60-70 years of age with MetS in rural health clinics around Babol, Iran in 2009. The participants were randomly assigned to one of the three groups of soy-nut, Textured Soy Protein (TSP) or control. Measurements were obtained before and after intervention.
   Results: The soy-nut improved FBG, insulin, HOMA-IR, MDA and TAC significantly after intervention (p<0.05); whereas, TSP established a significant decrease in serum insulin and MDA and increase in TAC compared to the control group (p<0.05). Comparing changes in means showed significant differences among all glucose control parameters, MDA and TAC in the treatment groups to the control group (p<0.001). The comparison of the treatments in the two groups showed that the mean changes in FBG, insulin and HOMA-IR levels in soy-nut group was significantly higher than TSP group (p<0.001).
   Conclusion: Both kinds of soy improved the oxidative stress and glycemic control status, but the soy-nut contributed more effectively than TSP. Therefore, it can be claimed that a moderate daily intake of soy may be a safe, cheap and practical way for the simultaneous improvement of oxidative stress and insulin resistance in elderly women with MetS.
C1 [Bakhtiary, A.] Babol Univ Med Sci, Women Dept, Fac Med, Babol Sar, Mazandaran, Iran.
   [Bakhtiary, A.] Univ Putra Malaysia, Inst Gerontol, Serdang, Selangor, Malaysia.
   [Yassin, Z.; Rahmat, A.] Univ Putra Malaysia, Dept Nutr & Dietet, Serdang, Selangor, Malaysia.
   [Hanachi, P.] Alzahra Univ, Dept Biol, Biochem Unite, Tehran, Iran.
   [Ahmad, Z.] Univ Putra Malaysia, Dept Family Med, Serdang, Selangor, Malaysia.
   [Halalkhor, S.] Babol Univ Med Sci, Dept Biochem & Biophys, Babol Sar, Mazandaran, Iran.
   [Firouzjahi, A. R.] Babol Univ Med Sci, Dept Pathol, Babol Sar, Mazandaran, Iran.
C3 Babol University of Medical Sciences; Universiti Putra Malaysia;
   Universiti Putra Malaysia; Alzahra University; Universiti Putra
   Malaysia; Babol University of Medical Sciences; Babol University of
   Medical Sciences
RP Bakhtiary, A (corresponding author), Babol Univ Med Sci, Women Dept, Fac Med, Babol Sar, Mazandaran, Iran.
EM afbakhtiari@gmail.com
RI Bakhtiari, Afsaneh/E-6390-2018; Hanachi, Parichehr/T-8487-2019;
   Sandrasaigaran, Pratheep/G-2122-2018; Halalkhor, Sohhrab/O-3806-2017
OI Hanachi, Parichehr/0000-0002-6450-203X; Halalkhor,
   Sohhrab/0000-0001-6210-337X; Bakhtiari, Afsaneh/0000-0002-4732-6900
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NR 42
TC 9
Z9 9
U1 0
U2 3
PU DONOTEDIT-ZAMENPUB
PI TALLINN
PA HARJU MAAKOND, SEPAPAJA TN 6, TALLINN, ESTONIA
SN 2074-1804
EI 2074-1812
J9 IRAN RED CRESCENT ME
JI Iran. Red Crescent Med. J.
PD NOV
PY 2011
VL 13
IS 11
BP 795
EP 804
PG 10
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 890AO
UT WOS:000300117700002
DA 2025-06-11
ER

PT J
AU Chen, YX
   Luo, NS
   Lin, YQ
   Yuan, WL
   Xie, SL
   Nie, RQ
   Wang, JF
AF Chen, Y. X.
   Luo, N. S.
   Lin, Y. Q.
   Yuan, W. L.
   Xie, S. L.
   Nie, R. Q.
   Wang, J. F.
TI Selective estrogen receptor modulators promising for cardiac syndrome X
SO JOURNAL OF POSTGRADUATE MEDICINE
LA English
DT Article
DE Cardiac syndrome X; estrogen deficiency; endothelial function;
   inflammation; selective estrogen receptor modulator; oxidative stress
ID POSTMENOPAUSAL WOMEN; ENDOTHELIAL DYSFUNCTION; LASOFOXIFENE CP-336,156;
   OXIDATIVE STRESS; PLUS PROGESTIN; NITRIC-OXIDE; RALOXIFENE; CHOLESTEROL;
   MENOPAUSE; THERAPY
AB Cardiac syndrome X (CSX) is defined as a typical anginal-like chest pain with a transient ischemic electrocardiogram, but without abnormal coronary angiography. It is usually accepted that endothelial dysfunction, inflammation, oxidative stress and estrogen deficiency are the main reasons of CSX. There are some methods to treat CSX including statins, beta blocker, angiotensin converting enzyme inhibitors, nitrates, estrogen, and so on. The estrogen replacement therapy (ERT), in particular, has been reported by many researchers to significantly reduce the frequency of chest pain after administration of estrogen, which has been explained as estrogen acting on its receptor to improve the endothelial function. However, it has been suggested that ERT must not be used for coronary heart disease due to its adverse effects. However, some selective estrogen receptor modulators (SERMs) can inhibit inflammatory response as well as oxidative stress, and improve the endothelial function, to reduce the occurrence of chest pain. Here, we hypothesize that SERMs may be the beneficial selection for patients with CSX.
C1 [Chen, Y. X.; Luo, N. S.; Lin, Y. Q.; Yuan, W. L.; Xie, S. L.; Nie, R. Q.; Wang, J. F.] Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Cardiol, Guangzhou 510120, Guangdong, Peoples R China.
C3 Sun Yat Sen University
RP Wang, JF (corresponding author), Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Cardiol, Guangzhou 510120, Guangdong, Peoples R China.
EM dr_wjf@hotmail.com
RI Chen, Chuanxi/F-3721-2019; Lin, Yu Qi/JGM-5066-2023
FU National Natural Science Foundation of China [30971262]
FX This paper was partly supported by National Natural Science Foundation
   of China to JingFeng Wang (No. 30971262)
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NR 40
TC 3
Z9 3
U1 0
U2 5
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, 400059, INDIA
SN 0022-3859
EI 0972-2823
J9 J POSTGRAD MED
JI J. Postgrad. Med.
PD OCT-DEC
PY 2010
VL 56
IS 4
BP 328
EP 331
DI 10.4103/0022-3859.70936
PG 4
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 739JM
UT WOS:000288713200021
PM 20935411
OA gold
DA 2025-06-11
ER

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   Thorp, Steven R.
   Jeste, Dilip V.
TI Is Post-Traumatic Stress Disorder Associated with Premature Senescence?
   A Review of the Literature
SO AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
LA English
DT Review
DE PTSD; aging; mortality; telomere; dementia
ID GILFORD-PROGERIA-SYNDROME; CORONARY-HEART-DISEASE; NATIONAL COMORBIDITY
   SURVEY; REPORTED HEALTH-PROBLEMS; METABOLIC SYNDROME; VIETNAM VETERANS;
   OXIDATIVE STRESS; TELOMERE LENGTH; MENTAL-HEALTH; COMBAT DEPLOYMENT
AB Objective: Post-traumatic stress disorder (PTSD) has major public health significance. Evidence that PTSD may be associated with premature senescence (early or accelerated aging) would have major implications for quality of life and healthcare policy. We conducted a comprehensive review of published empirical studies relevant to early aging in PTSD. Method: Our search included the PubMed, PsycINFO, and PILOTS databases for empirical reports published since the year 2000 relevant to early senescence and PTSD, including: 1) biomarkers of senescence (leukocyte telomere length [LTL] and pro-inflammatory markers), 2) prevalence of senescence-associated medical conditions, and 3) mortality rates. Results: All six studies examining LTL indicated reduced LTL in PTSD (pooled Cohen's d = 0.76). We also found consistent evidence of increased pro-inflammatory markers in PTSD (mean Cohen's ds), including C-reactive protein = 0.18, Interleukin-1 beta = 0.44, Interleukin-6 = 0.78, and tumor necrosis factor alpha = 0.81. The majority of reviewed studies also indicated increased medical comorbidity among several targeted conditions known to be associated with normal aging, including cardiovascular disease, type 2 diabetes mellitus, gastrointestinal ulcer disease, and dementia. We also found seven of 10 studies indicated PTSD to be associated with earlier mortality (average hazard ratio: 1.29). Conclusion: In short, evidence from multiple lines of investigation suggests that PTSD may be associated with a phenotype of accelerated senescence. Further research is critical to understand the nature of this association. There may be a need to re-conceptualize PTSD beyond the boundaries of mental illness, and instead as a full systemic disorder.
C1 [Lohr, James B.; Palmer, Barton W.; Eidt, Carolyn A.; Aailaboyina, Smitha; Thorp, Steven R.] VA Ctr Excellence Stress & Mental Hlth, San Diego, CA USA.
   [Lohr, James B.; Palmer, Barton W.; Eidt, Carolyn A.; Aailaboyina, Smitha; Mausbach, Brent T.; Thorp, Steven R.; Jeste, Dilip V.] Univ Calif San Diego, Dept Psychiat, San Diego, CA 92103 USA.
   [Lohr, James B.; Palmer, Barton W.; Eidt, Carolyn A.; Aailaboyina, Smitha; Mausbach, Brent T.; Thorp, Steven R.; Jeste, Dilip V.] Univ Calif San Diego, Sam & Rose Stein Inst Res Aging, San Diego, CA 92103 USA.
   [Wolkowitz, Owen M.] Univ Calif San Francisco, Dept Psychiat, San Francisco, CA USA.
C3 University of California System; University of California San Diego;
   University of California System; University of California San Diego;
   University of California System; University of California San Francisco
RP Lohr, JB (corresponding author), Vet Affairs San Diego Healthcare Syst, Ctr Excellence Stress & Mental Hlth MC 116A, 3350 La Jolla Village Dr, San Diego, CA 92161 USA.
EM jlohr@ucsd.edu
RI Palmer, Barton/A-6030-2019; Wolkowitz, Owen/J-6649-2013; Thorp,
   Steven/AAT-7321-2020
OI Palmer, Barton/0000-0002-7618-3144
FU VA Center of Excellence for Stress and Mental Health (CESAMH); National
   Institutes of Health [R01 MH099987, R01 MH094151, T32 MH019934];
   Department of Defense [W81XWH-12-1-0614]; University of California; San
   Diego Center for Healthy Aging; Sam and Rose Stein Institute for
   Research on Aging
FX This work was supported, in part, by the VA Center of Excellence for
   Stress and Mental Health (CESAMH), National Institutes of Health grants
   R01 MH099987, R01 MH094151, T32 MH019934, Department of Defense grant
   W81XWH-12-1-0614, and by the University of California, San Diego Center
   for Healthy Aging, and the Sam and Rose Stein Institute for Research on
   Aging.
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NR 100
TC 178
Z9 193
U1 0
U2 25
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1064-7481
EI 1545-7214
J9 AM J GERIAT PSYCHIAT
JI Am. J. Geriatr. Psychiatr.
PD JUL
PY 2015
VL 23
IS 7
BP 709
EP 725
DI 10.1016/j.jagp.2015.04.001
PG 17
WC Geriatrics & Gerontology; Gerontology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Psychiatry
GA CK0WN
UT WOS:000355926200007
PM 25959921
OA Bronze, Green Accepted
DA 2025-06-11
ER

PT J
AU Macias-Gonzalez, M
   Cardona, F
   Queipo-Ortuño, M
   Bernal, R
   Martin, M
   Tinahones, FJ
AF Macias-Gonzalez, Manuel
   Cardona, Fernando
   Queipo-Ortuno, Maribel
   Bernal, Rosa
   Martin, Miguel
   Tinahones, Francisco J.
TI PPARγ mRNA expression is reduced in peripheral blood mononuclear cells
   after fat overload in patients with metabolic syndrome
SO JOURNAL OF NUTRITION
LA English
DT Article
ID ACTIVATED-RECEPTOR-GAMMA; TYPE-2 DIABETES-MELLITUS; OXIDATIVE STRESS;
   POSTPRANDIAL HYPERTRIGLYCERIDEMIA; CARDIOVASCULAR-DISEASE; PROTEIN
   CARBONYLATION; PRO12ALA POLYMORPHISM; INSULIN-RESISTANCE;
   ADIPOSE-TISSUE; GENE
AB PPAR gamma is a transcriptional regulator of meta be I ism; its activity can be modulated by direct binding of dietary lipids. The most prevalent human PPAR gamma gene variant, Ala 12, is associated with postprandial hypertriglyceridemia inpatients with metabolic syndrome, although the mechanism whereby this polymorph ism affects lipid homeostas is remains to be fully determined. Using peripheral blood mononuclear cells (PBMC), we studied the effect of the Pro 12 and Ala 12 polymorph isms on mRNA expression of PPAR gamma and nuclear factor kappa B genes before and 3 and 4 h after fat overload. We also studied several biochemical and oxidative stress variables. Most of the indicators of oxidative stress were higher in patients with metabolic syndrome than in healthy subjects before and after fat overload. Patients also differed depending on whether they had the Pro12 or Ala12 variant in PBMC; PPAR gamma expression was lower in healthy subjects compared with patients. After fat overload, circulating triglycerides and PPAR gamma expression were positively correlated (r = 0.617, P < 0.05), and PPAR gamma expression tended to be negatively correlated with 2 important markers of oxidative stress: plasma lipid peroxidation (r= -0.224, P< 0.1) and carbonylated proteins (CPro) (r = -0.340, P< 0.1) concentrations. We also found differences in several indicators of oxidative stress between Pro12 and Ala12 patients, including an increase in plasma CPro before and after fat overload in Ala12 but not Pro12 patients. These data provide evidence that the Ala 12 sequence variant is associated with a worse metabolic profile than Pro12. This is related to differences in the expression of PPAR gamma and to oxidative imbalance after fat overload.
C1 [Macias-Gonzalez, Manuel; Cardona, Fernando; Queipo-Ortuno, Maribel; Bernal, Rosa; Martin, Miguel] Lab Invest, Fdn IMABIS, Malaga 29010, Spain.
   [Tinahones, Francisco J.] Hosp Virgen Victoria, Serv Endocrinol, Malaga 29010, Spain.
   [Bernal, Rosa; Martin, Miguel; Tinahones, Francisco J.] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr, Madrid 28029, Spain.
C3 FIMABIS; Hospital Virgen de la Victoria; CIBER - Centro de Investigacion
   Biomedica en Red; CIBEROBN; Instituto de Salud Carlos III
RP Macias-Gonzalez, M (corresponding author), Lab Invest, Fdn IMABIS, Malaga 29010, Spain.
EM mmacias.manuel@gmail.com
RI Bernal-Lopez, Rosa/F-3548-2011; Ortuño, María/AAC-1238-2021; Martin,
   Miguel/V-6589-2019; Cardona, Fernando/AAG-7835-2019; Tinahones,
   Francisco/AAB-2882-2020; MACIAS-GONZALEZ, MANUEL/E-7584-2016; Cardona,
   Fernando/H-6022-2015
OI MACIAS-GONZALEZ, MANUEL/0000-0002-6475-4704; Cardona,
   Fernando/0000-0003-4460-6824; Tinahones, Francisco
   J/0000-0001-6871-4403; Martin, Miguel/0000-0002-2036-1853; QUEIPO
   ORTUNO, MARIA ISABEL/0000-0002-2867-0845
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NR 36
TC 27
Z9 30
U1 0
U2 5
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0022-3166
EI 1541-6100
J9 J NUTR
JI J. Nutr.
PD MAY
PY 2008
VL 138
IS 5
BP 903
EP 907
DI 10.1093/jn/138.5.903
PG 5
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 290EF
UT WOS:000255105400014
PM 18424599
OA Bronze
DA 2025-06-11
ER

PT J
AU Abebe, Z
   Dickinson, K
   Mekonnen, TC
   Reynolds, A
   Appleton, S
   Mohammadi, L
   Eckert, DJ
   Adams, R
   Livingstone, KM
   Melaku, YA
AF Abebe, Zegeye
   Dickinson, Kacie
   Mekonnen, Tefera Chane
   Reynolds, Amy
   Appleton, Sarah
   Mohammadi, Leila
   Eckert, Danny J.
   Adams, Robert
   Livingstone, Katherine M.
   Melaku, Yohannes Adama
TI What Do Australians Eat? A Systematic Review of Dietary Patterns and
   Adverse Health Outcomes
SO NUTRITION REVIEWS
LA English
DT Review; Early Access
DE healthy dietary pattern; unhealthy dietary pattern; chronic diseases;
   health outcomes; Australia
ID BLOOD-PRESSURE; CANCER RISK; LIFE-STYLE; NUTRITION KNOWLEDGE;
   MEDITERRANEAN-STYLE; DIABETES-MELLITUS; COLORECTAL-CANCER; ASSOCIATIONS;
   SAMPLE; ADULTS
AB Context A suboptimal diet is a leading factor in the current burden of chronic diseases. In Australia, dietary factors contribute to one-fifth of the chronic disease burden. Understanding the dietary patterns of Australian adults and summarizing their effects on chronic conditions are imperative for improving interventions targeting dietary behaviors.Objective This systematic review aims to summarize the dietary patterns of Australian adults derived using a posteriori and hybrid analysis methods and their associations with adverse health outcomes.Data Sources Six databases were first searched in December 2020 and updated in August 2023.Data Extraction Cardiometabolic health, cardiovascular mortality, cancer, pregnancy-related metabolic conditions (gestational diabetes mellitus [GDM] or hypertensive disorders during pregnancy [HDP]), mental health, and cognitive function were the main health outcomes.Data Analysis Dietary patterns from each study were classified as either healthy or unhealthy. A narrative synthesis was used to describe the association of dietary patterns with adverse health outcomes in longitudinal studies. Fifty-nine observational studies (31 cross-sectional, 3 case-control, 22 longitudinal, and 3 combining both cross-sectional and longitudinal designs) were included, involving a total of 362 263 participants aged 18 years and older.Conclusion Higher adherence to a healthy dietary pattern (characterized by higher consumption of dark-yellow, green leafy, cruciferous vegetables and fruits, nuts, whole grains, tomatoes, fish, and low-fat dairy) is associated with improved cardiometabolic risk factors, reduced risk of GDM and HDP, better mental health, and improved pregnancy outcomes. On the other hand, an unhealthy dietary pattern (characterized by a higher intake of processed and red meat, takeaway foods, white bread, high-fat dairy, potatoes, discretionary fat, sweet snacks, soft drinks, fat spreads, jam, and Vegemite) is linked to increased cardiometabolic risks. Overall, while healthy dietary patterns are associated with a reduced risk of several physical and mental health outcomes, unhealthy dietary patterns are linked to an increased risk in Australian adults.Systematic Review Registration PROSPERO registration no. CRD42023452960.
C1 [Abebe, Zegeye; Reynolds, Amy; Appleton, Sarah; Eckert, Danny J.; Adams, Robert; Melaku, Yohannes Adama] Flinders Univ S Australia, Flinders Hlth & Med Res Inst, Mark Oliphant Bldg,L2,5 Laffer Dr, Bedford Pk, SA 5042, Australia.
   [Dickinson, Kacie] Flinders Univ S Australia, Caring Futures Inst, Coll Nursing & Hlth Sci, Bedford Pk, SA 5042, Australia.
   [Mekonnen, Tefera Chane] Univ Adelaide, Fac Hlth & Med Sci, Adelaide Med Sch, Adelaide, SA 5000, Australia.
   [Mohammadi, Leila] Cent Coast Local Hlth Dist, Directorate Clin Safety Qual & Governance Lib, Gosford, NSW, Australia.
   [Livingstone, Katherine M.] Deakin Univ, Inst Phys Act & Nutr IPAN, Sch Exercise & Nutr Sci, Geelong, Vic 3220, Australia.
C3 Flinders University South Australia; Flinders University South
   Australia; University of Adelaide; Central Coast Local Health District;
   Deakin University
RP Melaku, YA (corresponding author), Flinders Univ S Australia, Flinders Hlth & Med Res Inst, Mark Oliphant Bldg,L2,5 Laffer Dr, Bedford Pk, SA 5042, Australia.
EM yohannes.melaku@flinders.edu.au
RI Eckert, Danny/A-6145-2012; Dickinson, Kacie/G-7855-2011; Melaku,
   Yohannes/S-2451-2019; Mekonnen, Tefera/AAC-8002-2021; Livingstone,
   Katherine/AAA-5123-2021; Abebe, Zegeye/AAJ-6459-2020; Livingstone,
   A/Prof Katherine/R-7202-2016
OI Livingstone, A/Prof Katherine/0000-0002-9682-7541
FU National Health and Medical Research Council (NHMRC) [2009776]; NHMRC
   Emerging Leadership Fellowship [2009776, 1173803]; NHMRC Leadership
   Fellowship [1196261]
FX This research was funded by the National Health and Medical Research
   Council (NHMRC) (2009776). K.M.L. and Y.A.M. are supported by a NHMRC
   Emerging Leadership Fellowship (2009776 and 1173803). D.J.E. is
   supported by an NHMRC Leadership Fellowship (1196261). The findings of
   this review are solely the responsibility of the authors and do not
   represent the views of the funding institution.
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NR 120
TC 0
Z9 0
U1 0
U2 0
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0029-6643
EI 1753-4887
J9 NUTR REV
JI Nutr. Rev.
PD 2025 MAR 28
PY 2025
DI 10.1093/nutrit/nuaf028
EA MAR 2025
PG 20
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 0SH1Y
UT WOS:001454820200001
PM 40156601
DA 2025-06-11
ER

PT J
AU Elmadhun, NY
   Lassaletta, AD
   Chu, LM
   Liu, YH
   Feng, J
   Sellke, FW
AF Elmadhun, Nassrene Y.
   Lassaletta, Antonio D.
   Chu, Louis M.
   Liu, Yuhong
   Feng, Jun
   Sellke, Frank W.
TI Atorvastatin increases oxidative stress and modulates angiogenesis in
   Ossabaw swine with the metabolic syndrome
SO JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
LA English
DT Article
ID ENDOTHELIAL GROWTH-FACTOR; HIGH-DOSE ATORVASTATIN; NITRIC-OXIDE
   SYNTHASE; SIMVASTATIN; STATINS; AKT
AB Objective: The purpose of the present study was to evaluate the effect of atorvastatin on oxidative stress and angiogenesis in ischemic myocardium in a clinically relevant porcine model of the metabolic syndrome.
   Methods: Sixteen Ossabaw pigs were fed either a high-fat diet alone or a high-fat diet supplemented with atorvastatin (1.5 mg/kg daily) for 14 weeks. Chronic myocardial ischemia was induced by ameroid constrictor placement around the circumflex artery. After 6 months of the diet, myocardial perfusion was measured at rest and with demand pacing. The heart was harvested for analysis of perfusion, microvessel relaxation, protein expression, and oxidative stress.
   Results: Both groups had similar endothelium-dependent microvessel relaxation to adenosine diphosphate and endothelium-independent relaxation to sodium nitroprusside. Myocardial perfusion in the ischemic territory was also not significantly different either at rest or with demand pacing. Atorvastatin treatment increased total myocardial protein oxidation and serum lipid peroxidation. However, the expression of markers of oxidative stress, including NOX2, RAC1, myeloperoxidase, and superoxide dismutase 1, 2, and 3, were not statistically different. The expression of proangiogenic proteins endothelial nitric oxide synthase, phosphorylated endothelial nitric oxide synthase (Ser 1177), phosphorylated adenosine monophosphate kinase (Thr 172), phosphorylated extracellular signal-regulated kinase (T202, Y204), and vascular endothelial growth factor were all upregulated in the atorvastatin group.
   Conclusions: Atorvastatin increased the capillary and arteriolar density and upregulated the proangiogenic proteins endothelial nitric oxide synthase and phosphorylated endothelial nitric oxide synthase, phosphorylated adenosine monophosphate kinase, phosphorylated extracellular signal-regulated kinase, and vascular endothelial growth factor in a swine model of the metabolic syndrome. However, it failed to increase myocardial perfusion. Atorvastatin treatment was associated with increased myocardial and serum oxidative stress, which might contribute to the lack of collateral-dependent perfusion in the setting of angiogenesis. (J Thorac Cardiovasc Surg 2012;144:1486-93)
C1 [Elmadhun, Nassrene Y.; Lassaletta, Antonio D.; Chu, Louis M.; Liu, Yuhong; Feng, Jun; Sellke, Frank W.] Brown Univ, Warren Alpert Med Sch, Div Cardiothorac Surg, Cardiovasc Res Ctr, Providence, RI 02905 USA.
C3 Brown University
RP Sellke, FW (corresponding author), Brown Univ, Warren Alpert Med Sch, Div Cardiothorac Surg, Cardiovasc Res Ctr, 2 Dudley St,MOC 360, Providence, RI 02905 USA.
EM fsellke@lifespan.org
OI Feng, Jun/0000-0003-4762-7532
FU National Heart, Lung, and Blood Institute [R01HL46716, R01HL69024,
   R01HL85647]; National Institutes of Health [5T32-HL076134, 5T32 HL094300
   03]
FX Funding for this research was provided by the National Heart, Lung, and
   Blood Institute (grants R01HL46716, R01HL69024, and R01HL85647, Dr
   Sellke), National Institutes of Health Training grant 5T32-HL076134 (Dr
   Lassaletta), and National Institutes of Health Training grant 5T32
   HL094300 03 (Drs Chu and Elmadhun).
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NR 27
TC 28
Z9 30
U1 0
U2 8
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0022-5223
EI 1097-685X
J9 J THORAC CARDIOV SUR
JI J. Thorac. Cardiovasc. Surg.
PD DEC
PY 2012
VL 144
IS 6
BP 1486
EP 1493
DI 10.1016/j.jtcvs.2012.08.065
PG 8
WC Cardiac & Cardiovascular Systems; Respiratory System; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System; Surgery
GA 037FC
UT WOS:000311086600034
PM 22995723
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Cui, F
   Guan, Y
   Guo, J
   Tian, YM
   Hu, HF
   Zhang, XJ
   Zhang, Y
AF Cui, Fang
   Guan, Yue
   Guo, Jing
   Tian, Yan-Ming
   Hu, Hao-Fei
   Zhang, Xiang-Jian
   Zhang, Yi
TI Chronic intermittent hypobaric hypoxia protects vascular endothelium by
   ameliorating autophagy in metabolic syndrome rats
SO LIFE SCIENCES
LA English
DT Article
DE Chronic intermittent hypobaric hypoxia; Metabolic syndrome; Endothelium
   dependent relaxation; Endoplasmic reticulum stress; Autophagy
ID ENDOPLASMIC-RETICULUM STRESS; DYSFUNCTION; HYPERTENSION; FRUCTOSE
AB Aims: The study aimed to investigate the protective effect of chronic intermittent hypobaric hypoxia (CIHH) on endothelium function and relaxation of mesenteric artery in metabolism syndrome (MS) rats.
   Main methods: Male adult Sprague-Dawley rats were randomly divided into control (CON), CIHH (treated with 28-days hypobaric hypoxia simulating an altitude of 5000 m, 6 h daily), MS (induced by high fat diet and 10% fructose water feeding), and MS + CIHH groups. Body weight, systolic arterial pressure, blood biochemical and the endothelium dependent relaxation (EDR) of mesenteric arteries were measured. The expression of phosphorendothelial nitric oxide synthase (p-eNOS), endoplasmic reticulum (ER) stress-related proteins and autophagyrelated proteins in mesenteric arteries was assayed.
   Key findings: The MS rats displayed hypertension, obesity, metabolic abnormity and insulin resistance, EDR was attenuated, p-eNOS expression was down-regulated, the expressions of ER stress-related proteins were upregulated, and autophagy dysfunction occurred. All aforementioned abnormalities in MS rats were ameliorated in MS+ CIHH rats. Furthermore, the improvement of CIHH on EDR and p-eNOS was cancelled by the ER stress inducer, and the autophagy inhibitor.
   Significance: In conclusion CIHH protects endothelium function and enhances relaxation in mesenteric arteries of MS rats through improving autophagy function, reducing ER stress and up-regulating p-eNOS.
C1 [Cui, Fang; Guan, Yue; Tian, Yan-Ming; Zhang, Yi] Hebei Med Univ, Dept Physiol, Shijiazhuang 050017, Hebei, Peoples R China.
   [Cui, Fang] Hebei Med Univ, Dept Electron Microscope Lab Ctr, Shijiazhuang 050017, Hebei, Peoples R China.
   [Guo, Jing; Hu, Hao-Fei] Hebei Med Univ, Hosp 2, Dept Clin Lab, Shijiazhuang 050000, Hebei, Peoples R China.
   [Zhang, Xiang-Jian; Zhang, Yi] Hebei Collaborat Innovat Ctr Cardiocerebrovasc Di, Shijiazhuang 050000, Hebei, Peoples R China.
C3 Hebei Medical University; Hebei Medical University; Hebei Medical
   University
RP Zhang, Y (corresponding author), Hebei Med Univ, Dept Physiol, Shijiazhuang 050017, Hebei, Peoples R China.
EM zhyhenryphy@163.com
RI Zhang, Yipu/GXV-8541-2022
OI Zhang, Xiangjian/0000-0003-0114-1668; Shi, Min/0009-0004-8316-447X
FU National Natural Science Foundation of China [31071002, 31671184];
   National Basic Research Development Program of China [2012CB518200];
   Graduate Innovative Foundation of Hebei Education Department [2016179]
FX The study was supported by the National Natural Science Foundation of
   China (No. 31071002, No. 31671184), the National Basic Research
   Development Program of China (No. 2012CB518200), and the Graduate
   Innovative Foundation of Hebei Education Department (No. 2016179).
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NR 33
TC 16
Z9 17
U1 0
U2 20
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0024-3205
EI 1879-0631
J9 LIFE SCI
JI Life Sci.
PD JUL 15
PY 2018
VL 205
BP 145
EP 154
DI 10.1016/j.lfs.2018.05.008
PG 10
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA GI3TK
UT WOS:000434293900017
PM 29733850
DA 2025-06-11
ER

PT J
AU Buyck, JF
   Ankri, J
   Dugravot, A
   Bonnaud, S
   Nabi, H
   Kivimäki, M
   Singh-Manoux, A
AF Buyck, Jean-Francois
   Ankri, Joel
   Dugravot, Aline
   Bonnaud, Sophie
   Nabi, Hermann
   Kivimaki, Mika
   Singh-Manoux, Archana
TI Informal Caregiving and the Risk for Coronary Heart Disease: The
   Whitehall II Study
SO JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL
   SCIENCES
LA English
DT Article
DE Coronary heart disease; Stress; Caregiver
ID SELF-RATED HEALTH; SPOUSAL CAREGIVERS; METABOLIC SYNDROME; PHYSICAL
   HEALTH; STRESS; MORTALITY; WOMEN; POPULATION; DECLINE; IMPACT
AB The stress associated with informal caregiving has been shown to be associated with poor health, including coronary heart disease (CHD). However, it is unclear if the risk of CHD is attributable to caregiving or prior poor health of the caregiver.
   We used data from the Whitehall II cohort study. Caregiving and caregivers health (using 3 measures: self-rated health, mental health using the General Health Questionnaire, and physical component score of the SF-36) were assessed in 19911993 among 5,468 men and 2,457 women aged 3963 years. CHD (fatal CHD, clinically verified nonfatal myocardial infarction, and definite angina) incidence was recorded for a mean 17 years; sociodemographic variables, health behaviors, and cardiovascular risk factors were included as covariates.
   Cox regression showed the risk of CHD in caregivers not to be higher (hazard ratio 1.18; 95% CI: 0.96, 1.45) compared with noncaregivers. Analyses stratified by health status showed that compared with noncaregivers in good health, caregivers with poor self-rated (hazard ratio 2.00; 95% CI: 1.44, 2.78), mental (hazard ratio 1.63; 95% CI: 1.16, 2.30), or physical (hazard ratio 1.87; 95% CI: 1.34, 2.62) health had greater risk of CHD. A similar elevated risk was observed in noncaregivers with poor health; no excess risk was observed among caregivers reporting good health, and the combined effect of poor health and caregiving did not exceed their independent effects.
   Caregiving in midlife is not in itself associated with greater risk of CHD, but it is associated with increased risk for CHD among caregivers who report being in poor health.
C1 [Buyck, Jean-Francois; Ankri, Joel; Singh-Manoux, Archana] Univ Versailles St Quentin, Lab Sante Environm Vieillissement EA2506, AP HP, Paris, France.
   [Dugravot, Aline; Bonnaud, Sophie; Nabi, Hermann; Singh-Manoux, Archana] Hop Paul Brousse, Ctr Res Epidemiol & Populat Hlth, INSERM, U1018, F-94807 Villejuif, France.
   [Kivimaki, Mika; Singh-Manoux, Archana] UCL, Dept Epidemiol & Publ Hlth, London WC1E 6BT, England.
C3 Assistance Publique Hopitaux Paris (APHP); Universite Paris Saclay;
   Universite Paris Saclay; Institut National de la Sante et de la
   Recherche Medicale (Inserm); Assistance Publique Hopitaux Paris (APHP);
   Hopital Universitaire Paul-Brousse - APHP; University of London;
   University College London
RP Singh-Manoux, A (corresponding author), Hop Paul Brousse, Ctr Res Epidemiol & Populat Hlth, INSERM, U1018, Bat 15-16,16 Ave Paul Vaillant Couturier, F-94807 Villejuif, France.
EM Archana.Singh-Manoux@inserm.fr
RI Kivimaki, Mika/B-3607-2012; Singh-Manoux, Archana/F-6804-2013
OI Dugravot, Aline/0000-0002-4546-0970; Kivimaki, Mika/0000-0002-4699-5627;
   Ankri, Joel/0000-0002-0070-6471; Nabi, Hermann/0000-0002-7832-0413;
   Singh-Manoux, Archana/0000-0002-1244-5037
FU European Science Foundation; National Institute on Aging, National
   Institutes of Health (NIH) [R01AG013196, R01AG034454]; Academy of
   Finland; BUPA Foundation; NIH [R01AG034454, R01HL036310]; British
   Medical Research Council [G0902037]; British Heart Foundation; ESRC
   [ES/J023299/1] Funding Source: UKRI; MRC [G0902037, MR/K013351/1]
   Funding Source: UKRI
FX A.S.M. is supported by a "European Young Investigator Award" from the
   European Science Foundation and the National Institute on Aging,
   National Institutes of Health (NIH; R01AG013196 and R01AG034454). M. K.
   is supported by the Academy of Finland, the BUPA Foundation, and the NIH
   (R01HL036310 and R01AG034454). The Whitehall II study is also supported
   by a grant from the British Medical Research Council (G0902037) and the
   British Heart Foundation.
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NR 42
TC 49
Z9 51
U1 1
U2 18
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1079-5006
EI 1758-535X
J9 J GERONTOL A-BIOL
JI J. Gerontol. Ser. A-Biol. Sci. Med. Sci.
PD OCT
PY 2013
VL 68
IS 10
BP 1316
EP 1323
DI 10.1093/gerona/glt025
PG 8
WC Geriatrics & Gerontology; Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA 223TU
UT WOS:000324834600022
PM 23525476
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Demirkol, S
   Balta, S
   Unlu, M
   Yuksel, UC
   Celik, T
   Arslan, Z
   Kucuk, U
   Yokusoglu, M
AF Demirkol, Sait
   Balta, Sevket
   Unlu, Murat
   Yuksel, Uygar Cagdas
   Celik, Turgay
   Arslan, Zekeriya
   Kucuk, Ugur
   Yokusoglu, Mehmet
TI Evaluation of the mean platelet volume in patients with cardiac syndrome
   X
SO CLINICS
LA English
DT Article
DE Cardiac Syndrome X; Mean Platelet Volume; Subclinical Atherosclerosis;
   Endothelial Dysfunction
ID CORONARY-ARTERY-DISEASE; MYOCARDIAL-INFARCTION; CHEST-PAIN; COUNT;
   PATHOPHYSIOLOGY; HETEROGENEITY; ARTERIOGRAMS; RISK
AB OBJECTIVE: Cardiac syndrome X is characterized by angina-like chest pain, a positive stress test, and normal coronary arteries. A patient's mean platelet volume, which potentially reflects platelet function and activity, is associated with coronary atherosclerosis and endothelial dysfunction. The aim of the present study was to evaluate the mean platelet volumes of patients with cardiac syndrome X, those with coronary artery disease and normal subjects.
   METHODS: Two hundred thirty-six subjects (76 patients with cardiac syndrome X, 78 patients with coronary artery disease, and 82 controls) were enrolled in the study. All of the subjects were evaluated with a detailed medical history, physical examination, and biochemical analyses. The mean platelet volumes were compared between the three groups.
   RESULTS: The mean platelet volumes in the patients with cardiac syndrome X and with coronary artery disease were significantly higher than those that were observed in the control group. There were no significant differences in the mean platelet volumes between the cardiac syndrome X and the coronary artery disease groups.
   CONCLUSION: We have established that patients with cardiac syndrome X and coronary artery disease exhibit higher mean platelet volumes compared to controls. Patients with cardiac syndrome X exhibited higher mean platelet volumes compared to the controls, reflecting the presence of subclinical atherosclerosis. These findings suggest that, in addition to endothelial dysfunction, the presence of atherosclerosis may also contribute to the etiopathogenesis of cardiac syndrome X.
C1 [Demirkol, Sait; Balta, Sevket; Yuksel, Uygar Cagdas; Celik, Turgay; Kucuk, Ugur; Yokusoglu, Mehmet] Gulhane Mil Med Acad, Sch Med, Dept Cardiol, Ankara, Turkey.
   [Unlu, Murat] Beytepe Mil Hosp, Dept Cardiol, Ankara, Turkey.
   [Arslan, Zekeriya] Gelibolu Mil Hosp, Dept Cardiol, Canakkale, Turkey.
C3 Gulhane Military Medical Academy; Beytepe Military Hospital; Gallipoli
   Military Hospital
RP Demirkol, S (corresponding author), Gulhane Mil Med Acad, Sch Med, Dept Cardiol, Ankara, Turkey.
EM sdemirkol@gata.edu.tr
RI yuksel, uygar/AAA-5958-2021; Celik, Turgay/I-2981-2019
OI Balta, Sevket/0000-0002-6657-7334; Celik, Turgay/0000-0001-8418-0130;
   Arslan, Zekeriya/0000-0003-1497-1396
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NR 17
TC 84
Z9 85
U1 0
U2 9
PU HOSPITAL CLINICAS, UNIV SAO PAULO
PI SAO PAULO
PA FAC MEDICINA, UNIV SAO PAULO, SAO PAULO, SP 00000, BRAZIL
SN 1807-5932
J9 CLINICS
JI Clinics
PY 2012
VL 67
IS 9
BP 1019
EP 1022
DI 10.6061/clinics/2012(09)06
PG 4
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 012MQ
UT WOS:000309240800006
PM 23018297
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Zhong, P
   Sun, DM
   Wu, DH
   Li, TM
   Liu, XY
   Liu, HY
AF Zhong, P.
   Sun, D. M.
   Wu, D. H.
   Li, T. M.
   Liu, X. Y.
   Liu, H. Y.
TI Serum total bilirubin levels are negatively correlated with metabolic
   syndrome in aged Chinese women: a community-based study
SO BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
LA English
DT Article
DE Total bilirubin; Metabolic syndrome; Oxidative stress
ID OXIDATIVE STRESS; ANTIOXIDANT; DISEASE; ASSOCIATION; ADULTS; MEN
AB We evaluated serum total bilirubin levels as a predictor for metabolic syndrome (MetS) and investigated the relationship between serum total bilirubin levels and MetS prevalence. This cross-sectional study included 1728 participants over 65 years of age from Eastern China. Anthropometric data, lifestyle information, and previous medical history were collected. We then measured serum levels of fasting blood-glucose, total cholesterol, triglycerides, and total bilirubin, as well as alanine aminotransferase activity. The prevalence of MetS and each of its individual component were calculated per quartile of total bilirubin level. Logistic regression was used to assess the correlation between serum total bilirubin levels and MetS. Total bilirubin level in the women who did not have MetS was significantly higher than in those who had MetS (P < 0.001). Serum total bilirubin quartiles were linearly and negatively correlated with MetS prevalence and hypertriglyceridemia (HTG) in females (P < 0.005). Logistic regression showed that serum total bilirubin was an independent predictor of MetS for females (OR: 0.910, 95% CI: 0.863-0.960; P=0.001). The present study suggests that physiological levels of serum total bilirubin might be an independent risk factor for aged Chinese women, and the prevalence of MetS and HTG are negatively correlated to serum total bilirubin levels.
C1 [Zhong, P.; Li, T. M.; Liu, X. Y.] Shanghai Univ Chinese Med, Shanghai TCM Integrated Hosp, Dept Neurol, Shanghai, Peoples R China.
   [Sun, D. M.] Puxing Community Hlth Serv Ctr, Shanghai, Peoples R China.
   [Wu, D. H.] Shanghai Jiao Tong Univ, Sch Med, Dept Neurol, Peoples Hosp 3, Shanghai, Peoples R China.
   [Wu, D. H.] Fudan Univ, Shanghai Peoples Hosp 5, Dept Neurol, Shanghai, Peoples R China.
   [Liu, H. Y.] Pingliang Community Hlth Serv Ctr, Shanghai, Peoples R China.
C3 Shanghai University of Traditional Chinese Medicine; Shanghai Jiao Tong
   University; Fudan University
RP Wu, DH (corresponding author), Shanghai Jiao Tong Univ, Sch Med, Dept Neurol, Peoples Hosp 3, Shanghai, Peoples R China.; Wu, DH (corresponding author), Fudan Univ, Shanghai Peoples Hosp 5, Dept Neurol, Shanghai, Peoples R China.
EM kathywuxue@sina.com
RI Zhong, Ping/KRQ-8664-2024
FU Shanghai Senior Clinicians of Integrated Chinese and Western Medicines
   Training Project [ZYSNXD012-RC-ZXY019]; Scientific Research Funds of
   Shanghai Health and Family Planning Committee [201540207, 201440332]
FX This study was supported by the Shanghai Senior Clinicians of Integrated
   Chinese and Western Medicines Training Project (ZYSNXD012-RC-ZXY019) and
   the Scientific Research Funds of Shanghai Health and Family Planning
   Committee (201540207and201440332).
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NR 26
TC 13
Z9 14
U1 0
U2 7
PU ASSOC BRAS DIVULG CIENTIFICA
PI SAO PAULO
PA FACULDADE MEDICINA, SALA 21, 14049 RIBEIRAO PRETO, SAO PAULO, 00, BRAZIL
SN 0100-879X
EI 1678-4510
J9 BRAZ J MED BIOL RES
JI Brazilian J. Med. Biol. Res.
PY 2017
VL 50
IS 2
AR e5252
DI 10.1590/1414-431X20165252
PG 6
WC Biology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics; Research & Experimental
   Medicine
GA EK7ZU
UT WOS:000394144500001
PM 28146216
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Feoli, AMP
   Macagnan, FE
   Piovesan, CH
   Bodanese, LC
   Siqueira, IR
AF Pandolfo Feoli, Ana Maria
   Macagnan, Fabricio Edler
   Piovesan, Carla Haas
   Bodanese, Luiz Carlos
   Siqueira, Ionara Rodrigues
TI Xanthine Oxidase Activity Is Associated with Risk Factors for
   Cardiovascular Disease and Inflammatory and Oxidative Status Markers in
   Metabolic Syndrome: Effects of a Single Exercise Session
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Article
ID URIC-ACID; ENDOTHELIAL DYSFUNCTION; ADIPOSE-TISSUE; STRESS; SERUM;
   OXIDOREDUCTASE; RESISTANCE; PROFILE; PLASMA; MEN
AB Objective. The main goal of the present study was to investigate the xanthine oxidase (XO) activity in metabolic syndrome in subjects submitted to a single exercise session. We also investigated parameters of oxidative and inflammatory status. Materials/Methods. A case-control study (9 healthy and 8 MS volunteers) was performed to measure XO, superoxide dismutase (SOD), glutathione peroxidase activities, lipid peroxidation, high-sensitivity C-reactive protein (hsCRP) content, glucose levels, and lipid profile. Body mass indices, abdominal circumference, systolic and diastolic blood pressure, and TG levels were also determined. The exercise session consisted of 3 minutes of stretching, 3 minutes of warm-up, 30 minutes at a constant dynamic workload at a moderate intensity, and 3 minutes at a low speed. The blood samples were collected before and 15 minutes after the exercise session. Results. Serum XO activity was higher in MS group compared to control group. SOD activity was lower in MS subjects. XO activity was correlated with SOD, abdominal circumference, body mass indices, and hsCRP. The single exercise session reduced the SOD activity in the control group. Conclusions. Our data support the association between oxidative stress and risk factors for cardiovascular diseases and suggest XO is present in the pathogenesis of metabolic syndrome.
C1 [Pandolfo Feoli, Ana Maria; Piovesan, Carla Haas] Pontificia Univ Catolica Rio Grande do Sul, Fac Enfermagem Nutr & Fisioterapia, BR-90619900 Porto Alegre, RS, Brazil.
   [Macagnan, Fabricio Edler; Piovesan, Carla Haas; Bodanese, Luiz Carlos] Pontificia Univ Catolica Rio Grande do Sul, Programa Posgrad Med & Ciencias Saude, BR-90619900 Porto Alegre, RS, Brazil.
   [Siqueira, Ionara Rodrigues] Pontificia Univ Catolica Rio Grande do Sul, Inst Ciencias Basicas Saude, Dept Farmacol, BR-90619900 Porto Alegre, RS, Brazil.
C3 Pontificia Universidade Catolica Do Rio Grande Do Sul; Pontificia
   Universidade Catolica Do Rio Grande Do Sul; Pontificia Universidade
   Catolica Do Rio Grande Do Sul
RP Feoli, AMP (corresponding author), Pontificia Univ Catolica Rio Grande do Sul, Fac Enfermagem Nutr & Fisioterapia, Ave Ipiranga 6681,Predio 12,8 Andar, BR-90619900 Porto Alegre, RS, Brazil.
EM anamariafeoli@hotmail.com
RI Macagnan, Fabrício/AAP-5564-2021; Siqueira, Ionara/J-8764-2018; Feoli,
   Ana/A-1748-2015
OI Feoli, Ana/0000-0001-7685-8431
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NR 45
TC 55
Z9 56
U1 0
U2 2
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PY 2014
VL 2014
AR 587083
DI 10.1155/2014/587083
PG 8
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA AI0MS
UT WOS:000336542300001
PM 24967004
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Choi, JI
   Han, KD
   Kim, SJ
   Kim, MJ
   Shin, JE
   Lee, HN
AF Choi, Jeong In
   Han, Kyung-do
   Kim, Sa Jin
   Kim, Min Jeong
   Shin, Jae Eun
   Lee, Hae Nam
TI Relationship between delivery history and health-related quality of life
   in menopausal South Korean women: The Korea National Health and
   Nutrition Examination Surveys
SO MATURITAS
LA English
DT Article
DE Korean National Health and Nutrition; Examination Surveys; Delivery
   history; Health-related quality of life; EuroQol index
ID NATURAL MENOPAUSE; 1ST CHILDBIRTH; AGE; PREGNANCY; IMPACT; RISK;
   OUTCOMES; EUROQOL; COHORT; BIRTH
AB Objectives: The study investigated the association between childbirth history and health-related quality of life (QOL) in menopausal South Korean women.
   Study design: Cross-sectional analysis of data from the 2010-2012 Korean National Health and Nutrition Examination Surveys (KNHANES) for 4277 menopausal women aged over 50. We used the EuroQol index to measure health-related QOL.
   Main outcome measures: The relationship between delivery history and health-related QOL in menopausal South Korean women was analyzed.
   Results: After adjustment for age (model 1), women who were younger at their first delivery and who had a greater number of deliveries had a significantly higher risk of problems with mobility, self-care, usual activities and pain or discomfort; the risk of anxiety or depression was not increased. After adjustment for age, BMI, smoking, use of alcohol, exercise, income, education, marital status, metabolic syndrome and stress (model 2), women who were younger at their first delivery and who had a greater number of deliveries had a significantly higher risk of problems with mobility, self-care and pain or discomfort. Age at last delivery was not significantly associated with health-related QOL in either model.
   Conclusions: South Korean women who were younger at their first delivery and who had more deliveries appear to be at increased risk of health-related QOL problems after menopause. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
C1 [Choi, Jeong In; Kim, Sa Jin; Kim, Min Jeong; Shin, Jae Eun; Lee, Hae Nam] Catholic Univ Korea, Coll Med, Bucheon St Marys Hosp, Dept Obstet & Gynecol, Seoul, South Korea.
   [Han, Kyung-do] Catholic Univ Korea, Coll Med, Dept Biostat, Seoul, South Korea.
C3 Catholic University of Korea; Catholic University of Korea
RP Lee, HN (corresponding author), Bucheon St Marys Hosp, 327 Sosa Ro, Bucheon Si 420717, Gyeonggi Do, South Korea.
EM leehaenam@catholic.ac.kr
RI Han, Kyungdo/JKH-7628-2023; Kim, Joo/X-7562-2019
OI Choi, Jeong In/0000-0001-8023-084X
CR Alonzo AA, 2002, WOMEN HEALTH ISS, V12, P37, DOI 10.1016/S1049-3867(01)00135-9
   [Anonymous], 2007, EQ-5D Korean valuation study using time trade off method
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NR 29
TC 7
Z9 7
U1 2
U2 8
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0378-5122
EI 1873-4111
J9 MATURITAS
JI Maturitas
PD OCT
PY 2016
VL 92
BP 24
EP 29
DI 10.1016/j.maturitas.2016.07.002
PG 6
WC Geriatrics & Gerontology; Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Obstetrics & Gynecology
GA DY0LG
UT WOS:000384787700005
PM 27621234
DA 2025-06-11
ER

PT J
AU Lee, BJ
   Chan, MY
   Hsiao, HY
   Chang, CH
   Hsu, LP
   Lin, PT
AF Lee, Bor-Jen
   Chan, Man-Yee
   Hsiao, Han-Yu
   Chang, Chia-Hua
   Hsu, Li-Ping
   Lin, Ping-Ting
TI Relationship of Oxidative Stress, Inflammation, and the Risk of
   Metabolic Syndrome in Patients with Oral Cancer
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Article
ID ARECA NUT EXTRACT; BETEL-NUT; ANTIOXIDANT STATUS; PROSTAGLANDIN E-2;
   CONSUMPTION; ASSOCIATION; INTERLEUKIN-6; INGREDIENTS; INDUCTION; DISEASE
AB Oral cancer is the fifth leading cause of cancer death in Taiwan, and the prevalence of metabolic syndrome (MS) has also increased globally. The purpose of this study was to investigate the correlations between the components of MS and oxidative stress and inflammation in patients with oral cancer based on their areca-nut-chewing habits. Two hundred patients diagnosed with oral cancer were recruited, and metabolic parameters, oxidative stress, antioxidant enzyme activities, and inflammatory markers were measured. 63% of the subjects have concomitant MS. Subjects who had an areca-nut-chewing habit had significantly higher levels of fasting glucose (p = 0 04), oxidative stress (p = 0 02), and inflammatory markers (p = 0 02) than those who never chewed. High-density lipoprotein-cholesterol level (p = 0 03) and superoxidase dismutase activity (p = 0 02) were significantly lower in individuals who had chewed or were currently chewers. Areca-nut-chewing habit was associated with the increased risks for MS and hypertriglyceridemia; the components of MS were positively correlated with oxidative stress and inflammation. In conclusion, patients with oral cancer who had an areca-nut-chewing habit exhibited higher levels of oxidative stress and inflammation, which might be related to an increased risk of MS.
C1 [Lee, Bor-Jen] Taichung Vet Gen Hosp, Dept Crit Care Med, Taichung 40705, Taiwan.
   [Lee, Bor-Jen] Chung Shan Med Univ, Sch Med, Taichung 40201, Taiwan.
   [Chan, Man-Yee; Hsiao, Han-Yu] Taichung Vet Gen Hosp, Div Oral & Maxillofacial Surg, Dept Dent, Taichung 40705, Taiwan.
   [Chan, Man-Yee] Chung Shan Med Univ, Sch Dent, Coll Oral Med, Taichung 40201, Taiwan.
   [Chang, Chia-Hua; Hsu, Li-Ping; Lin, Ping-Ting] Chung Shan Med Univ, Dept Nutr, Taichung 40201, Taiwan.
   [Lin, Ping-Ting] Chung Shan Med Univ Hosp, Dept Nutr, Taichung 40201, Taiwan.
C3 Taichung Veterans General Hospital; Chung Shan Medical University;
   Taichung Veterans General Hospital; Chung Shan Medical University; Chung
   Shan Medical University; Chung Shan Medical University; Chung Shan
   Medical University Hospital
RP Lin, PT (corresponding author), Chung Shan Med Univ, Dept Nutr, Taichung 40201, Taiwan.; Lin, PT (corresponding author), Chung Shan Med Univ Hosp, Dept Nutr, Taichung 40201, Taiwan.
EM apt810@csmu.edu.tw
OI Lin, Ping-Ting/0000-0002-4271-3928
FU Ministry of Health and Welfare, Taiwan [MOHW103-TD-B-111-10,
   MOHW104-TDU-B-211-124004, MOHW105-TDU-B-211-134002,
   MOHW106-TDU-B-211-144002, MOST 105-2628-B-040-004-MY2]
FX This study was supported by grants from the Ministry of Health and
   Welfare, Taiwan (MOHW103-TD-B-111-10, MOHW104-TDU-B-211-124004,
   MOHW105-TDU-B-211-134002, MOHW106-TDU-B-211-144002, and MOST
   105-2628-B-040-004-MY2). The authors would like to express our sincere
   appreciation to the subjects for their participation. The authors also
   thank the nurses at Taichung Veterans General Hospital for providing
   their expertise in blood sample collection.
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NR 40
TC 21
Z9 23
U1 0
U2 5
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PY 2018
VL 2018
AR 9303094
DI 10.1155/2018/9303094
PG 7
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA GI1SE
UT WOS:000434150000001
PM 29951168
OA Green Published, hybrid, Green Submitted
DA 2025-06-11
ER

PT J
AU Singhal, SS
   Figarola, J
   Singhal, J
   Reddy, MA
   Liu, XL
   Berz, D
   Natarajan, R
   Awasthi, S
AF Singhal, Sharad S.
   Figarola, James
   Singhal, Jyotsana
   Reddy, Marpadga A.
   Liu, Xueli
   Berz, David
   Natarajan, Rama
   Awasthi, Sanjay
TI RLIP76 Protein Knockdown Attenuates Obesity Due to a High-fat Diet
SO JOURNAL OF BIOLOGICAL CHEMISTRY
LA English
DT Article
ID ENDOPLASMIC-RETICULUM STRESS; LEPTIN RESISTANCE; ADIPOCYTE HYPERTROPHY;
   DIABETIC-NEPHROPATHY; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   GENE-EXPRESSION; KIDNEY-DISEASE; IN-VITRO; EPIDEMIOLOGY
AB Feeding a Western high-fat diet (HFD) to C57BL/6 mice induces obesity, associated with a chronic inflammatory state, lipid transport, and metabolic derangements, and organ system effects that particularly prominent in the kidneys. Here, we report that RLIP76 homozygous knock-out (RLIP76(-/-)) mice are highly resistant to obesity as well as these other features of metabolic syndrome caused by HFD. The normal increase in pro-inflammatory and fibrotic markers associated with HFD induced obesity in wild-type C57B mice was broadly and nearly completely abrogated in RLIP76(-/-) mice. This is a particularly striking finding because chemical markers of oxidative stress including lipid hydroperoxides and alkenals were significantly higher in RLIP76(-/-) mice. Whereas HFD caused marked suppression of AMPK in wild-type C57B mice, RLIP76(-/-) mice had baseline activation of AMP-activated protein kinase, which was not further affected by HFD. The baseline renal function was reduced in RLIP76(-/-) mice as compared with wild-type, but was unaffected by HFD, in marked contrast to severe renal impairment and glomerulopathy in the wild-type mice given HFD. Our findings confirm a fundamental role of RLIP76 in regulating the function of obesity-promoting pro-inflammatory cytokines, and provide a novel mechanism for targeted therapy of obesity and metabolic syndrome.
C1 [Singhal, Sharad S.; Figarola, James; Singhal, Jyotsana; Reddy, Marpadga A.; Berz, David; Natarajan, Rama; Awasthi, Sanjay] City Hope Natl Med Ctr, Ctr Comprehens Canc, Beckman Res Inst, Dept Diabet & Metab Dis Res, Duarte, CA 91010 USA.
   [Liu, Xueli] City Hope Natl Med Ctr, Ctr Comprehens Canc, Beckman Res Inst, Dept Biostat, Duarte, CA 91010 USA.
C3 City of Hope; Beckman Research Institute of City of Hope; City of Hope;
   Beckman Research Institute of City of Hope
RP Singhal, SS (corresponding author), City Hope Natl Med Ctr, Ctr Comprehens Canc, Beckman Res Inst, Dept Diabet & Metab Dis Res, Duarte, CA 91010 USA.
EM ssinghal@coh.org; sawasthi@coh.org
RI liu, xueli/LVR-7450-2024; Awasthi, Sanjay/R-4904-2019; Singhal,
   Ashutosh/H-6725-2019
OI Singhal, Jyotsana/0009-0004-0119-9370; Awasthi,
   Sanjay/0000-0002-5214-5717; FIGAROLA, JAMES/0000-0003-3948-6282; Reddy,
   Marpadga A/0000-0001-9259-7243
FU National Institutes of Health from the NCI [RO1 CA77495]; Perricone
   Family Foundation, Los Angeles, CA; Beckman Research Institute of the
   City of Hope
FX This work was supported, in whole or in part, by National Institutes of
   Health Grant RO1 CA77495 (to S. A.) from the NCI, and funds from the
   Perricone Family Foundation, Los Angeles, CA, and the Beckman Research
   Institute of the City of Hope (to S. A.).
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NR 57
TC 20
Z9 21
U1 0
U2 5
PU AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3996 USA
EI 1083-351X
J9 J BIOL CHEM
JI J. Biol. Chem.
PD AUG 9
PY 2013
VL 288
IS 32
BP 23394
EP 23406
DI 10.1074/jbc.M113.480194
PG 13
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 302IN
UT WOS:000330598200043
PM 23821548
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Lee, MY
   Koh, SB
   Koh, JH
   Nam, SM
   Shin, JY
   Shin, YG
   Kong, ID
   Ryu, SY
   Lee, TY
   Park, JK
   Chung, CH
AF Lee, M. Y.
   Koh, S. B.
   Koh, J. H.
   Nam, S. M.
   Shin, J. Y.
   Shin, Y. G.
   Kong, I. D.
   Ryu, S. Y.
   Lee, T. Y.
   Park, J. K.
   Chung, C. H.
TI Relationship between γ-glutamyltransferase and metabolic syndrome in a
   Korean population
SO DIABETIC MEDICINE
LA English
DT Article
DE gamma-glutamyltransferase; metabolic syndrome; oxidative stress; insulin
   resistance; inflammation
ID C-REACTIVE PROTEIN; REDUCED INSULIN SENSITIVITY; MIDDLE-AGED MEN;
   ALANINE AMINOTRANSFERASE; OXIDATIVE STRESS; PLASMA-PROTEIN;
   LIVER-ENZYMES; RISK; INFLAMMATION; ADIPONECTIN
AB Aims To investigate associations between gamma-glutamyltransferase (GGT) and components of metabolic syndrome (MS), insulin resistance and inflammatory markers in the Korean population.
   Methods The 3508 subjects enrolled in this survey participated in the Korean Rural Genomic Cohort (KRGC) study. Written consent was obtained from the local ethical committee. Of these participants, 1437 were men (mean age 56.9 +/- 7.9 years) and 2071 were women (mean age 55.8 +/- 8.1 years). We measured GGT levels and various biochemical markers. To examine insulin resistance status, we used the homeostasis assessment method for insulin resistance (HOMA-IR). For inflammatory marker, we used C-reactive protein (CRP) levels.
   Results Serum GGT levels were significantly higher in the MS group compared to the healthy patient group [23 (5-1403) vs. 19 (5-1920) IU/l; P = 0.01]. The prevalence of MS and adjusted relative risk were both significantly increased from the lowest to highest GGT quartiles; these results persisted after adjustments for multiple confounders. Positive correlations were established between GGT and HOMA-IR or CRP.
   Conclusion These results suggest that GGT levels may be a surrogate marker of insulin resistance, inflammation and MS.
C1 [Lee, M. Y.; Koh, J. H.; Nam, S. M.; Shin, J. Y.; Shin, Y. G.; Chung, C. H.] Yonsei Univ, Wonju Coll Med, Dept Internal Med, Wonju, South Korea.
   [Kong, I. D.; Chung, C. H.] Yonsei Univ, Wonju Coll Med, Inst Lifelong Hlth, Wonju, South Korea.
   [Koh, S. B.; Park, J. K.] Yonsei Univ, Wonju Coll Med, Dept Prevent Med, Wonju, South Korea.
   [Koh, S. B.; Park, J. K.] Yonsei Univ, Wonju Coll Med, Inst Occupat Med, Wonju, South Korea.
   [Kong, I. D.] Yonsei Univ, Wonju Coll Med, Dept Physiol, Wonju, South Korea.
   [Ryu, S. Y.] Chosun Univ, Coll Med, Dept Prevent Med, Kwangju, South Korea.
   [Lee, T. Y.] Chungnam Natl Univ, Coll Med, Dept Prevent Med, Taejon, South Korea.
C3 Yonsei University; Yonsei University; Yonsei University; Yonsei
   University; Yonsei University; Chosun University; Chungnam National
   University
RP Chung, CH (corresponding author), Yonsei Univ, Wonju Coll Med, Dept Internal Med, Wonju, South Korea.
EM jkpark@yonsei.ac.kr; cchung@yonsei.ac.kr
RI Cho, Young/J-5669-2012
OI Chung, Choon/0000-0003-1144-7206
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NR 38
TC 28
Z9 29
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0742-3071
EI 1464-5491
J9 DIABETIC MED
JI Diabetic Med.
PD APR
PY 2008
VL 25
IS 4
BP 469
EP 475
DI 10.1111/j.1464-5491.2008.02415.x
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 283AX
UT WOS:000254610000013
PM 18346161
DA 2025-06-11
ER

PT J
AU Aaseth, J
   Roer, GE
   Lien, L
   Bjorklund, G
AF Aaseth, Jan
   Roer, Grethe Emilie
   Lien, Lars
   Bjorklund, Geir
TI Is there a relationship between PTSD and complicated obesity? A review
   of the literature
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Review
DE PTSD; Obesity; Cortisol; Leptin; Ghrelin; Metabolic syndrome
ID POSTTRAUMATIC-STRESS-DISORDER; ADIPOSE-TISSUE LIPOLYSIS; LOW-GRADE
   INFLAMMATION; WORLD-TRADE-CENTER; INSULIN-RESISTANCE;
   CARDIOVASCULAR-DISEASE; CHILDHOOD ADVERSITY; METABOLIC SYNDROME; LEPTIN
   RESISTANCE; MENTAL-DISORDERS
AB Recent research strongly supports the hypothesis that posttraumatic stress disorder (PTSD) can be accompanied by obesity and related metabolic disturbances. The mechanisms of these associations are however still not well defined, although disturbed functions in the sympathetic-adrenergic nervous system together with the disturbed release of hormones via the endocrine HPA (hypothalamic-pituitary-adrenal) axis apparently play a role. Leptin resistance and ghrelin excesses might contribute to a disturbed hypothalamic function, and also disturb other cerebral functions, leading to dysfunctional reward signaling and uncontrolled appetite combined with a tendency to alcohol abuse. Secondarily, cortisol stimulation will contribute to the development of central obesity which is known to facilitate the development of metabolic syndrome, including slightly increased levels of inflammatory biomarkers such as C-reactive protein and fibrinogen. While previous therapeutic strategies have focused on early psychotherapeutic interventions in PTSD, the present review emphasizes the importance of better therapeutic approaches regarding the somatic correlates of the syndrome. Strict regulation of dietary meals and food composition with minimal intake of sweets and saturated fat, as well as alcohol avoidance, can provide a basic therapeutic framework. A cognitive psychotherapeutic approach with graduated desensitization toward trigging factors, combined with pharmacotherapy, is discussed in the present review.
C1 [Aaseth, Jan] Innlandet Hosp Trust, Res Dept, Pb 104, N-2381 Brumunddal, Norway.
   [Aaseth, Jan; Roer, Grethe Emilie; Lien, Lars] Inland Norway Univ Appl Sci, Fac Hlth & Social Sci, Elverum, Norway.
   [Lien, Lars] Innlandet Hosp Trust, Norwegian Natl Advisory Unit Concurrent Subst Abu, Ottestad, Norway.
   [Bjorklund, Geir] Council Nutr & Environm Med, Toften 24, N-8610 Mo I Rana, Norway.
C3 Innlandet Hospital Trust; Inland Norway University of Applied Sciences;
   Innlandet Hospital Trust
RP Aaseth, J (corresponding author), Innlandet Hosp Trust, Res Dept, Pb 104, N-2381 Brumunddal, Norway.; Bjorklund, G (corresponding author), Council Nutr & Environm Med, Toften 24, N-8610 Mo I Rana, Norway.
EM jaol-aas@online.no; bjorklund@conem.org
RI Aaseth, Jan/J-6764-2017; Bjorklund, Geir/B-7319-2014
OI Bjorklund, Geir/0000-0003-2632-3935
FU Innlandet Hospital Trust and Inland Norway University for Applied
   Sciences
FX Innlandet Hospital Trust and Inland Norway University for Applied
   Sciences are acknowledged for support.
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NR 86
TC 29
Z9 32
U1 0
U2 15
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD SEP
PY 2019
VL 117
AR 108834
DI 10.1016/j.biopha.2019.108834
PG 6
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA IM2EA
UT WOS:000477804500059
PM 31177066
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Koomen, LEM
   van de Meent, IHT
   Deenik, J
   van Dellen, E
   Schnack, HG
   van Werkhoven, H
   Swildens, WE
   van Meijel, B
   Staal, W
   Jörg, F
   Scheepers, F
   Cahn, W
AF Koomen, Lisanne Elisabeth Maria
   van de Meent, Ilona Hendrika Theodora
   Deenik, Jeroen
   van Dellen, Edwin
   Schnack, Hugo Gerard
   van Werkhoven, Henri
   Swildens, Wilma Elisabeth
   van Meijel, Berno
   Staal, Wouter
   Jorg, Frederike
   Scheepers, Floortje
   Cahn, Wiepke
TI Muva physical activity intervention to improve social functioning in
   people with a severe mental illness: study protocol of a pragmatic
   stepped wedge cluster randomized trial
SO BMC PSYCHIATRY
LA English
DT Article
DE Severe mental illness; Social functioning; Physical activity; Healthy
   lifestyle; Supported housing; Implementation
ID LIFE-STYLE; HEALTH-PROMOTION; SCHIZOPHRENIA; MORTALITY; BARRIERS;
   EXERCISE; DIET; RELIABILITY; DISORDERS; COMMUNITY
AB Background: People with severe mental illness (SMI) often suffer from long-lasting symptoms that negatively influence their social functioning, their ability to live a meaningful life, and participation in society. Interventions aimed at increasing physical activity can improve social functioning, but people with SMI experience multiple barriers to becoming physically active. Besides, the implementation of physical activity interventions in day-to-day practice is difficult. In this study, we aim to evaluate the effectiveness and implementation of a physical activity intervention to improve social functioning, mental and physical health.
   Methods: In this pragmatic stepped wedge cluster randomized controlled trial we aim to include 100 people with SMI and their mental health workers from a supported housing organization. The intervention focuses on increasing physical activity by implementing group sports activities, active guidance meetings, and a serious game to set physical activity goals. We aim to decrease barriers to physical activity through active involvement of the mental health workers, lifestyle courses, and a medication review. Participating locations will be divided into four clusters and randomization will decide the start of the intervention. The primary outcome is social functioning. Secondary outcomes are quality of life, symptom severity, physical activity, cardiometabolic risk factors, cardiorespiratory fitness, and movement disturbances with specific attention to postural adjustment and movement sequencing in gait. In addition, we will assess the implementation by conducting semi-structured interviews with location managers and mental health workers and analyze them by direct content analysis.
   Discussion: This trial is innovative since it aims to improve social functioning in people with SMI through a physical activity intervention which aims to lower barriers to becoming physically active in a real-life setting. The strength of this trial is that we will also evaluate the implementation of the intervention. Limitations of this study are the risk of poor implementation of the intervention, and bias due to the inclusion of a medication review in the intervention that might impact outcomes.
C1 [Koomen, Lisanne Elisabeth Maria; van de Meent, Ilona Hendrika Theodora; Deenik, Jeroen; van Dellen, Edwin; Schnack, Hugo Gerard; van Werkhoven, Henri; Scheepers, Floortje; Cahn, Wiepke] UMC Utrecht, Utrecht Brain Ctr, Utrecht, Netherlands.
   [Koomen, Lisanne Elisabeth Maria] Lister, Utrecht, Netherlands.
   [van de Meent, Ilona Hendrika Theodora; Schnack, Hugo Gerard] Univ Utrecht, Utrecht, Netherlands.
   [Deenik, Jeroen] Maastricht Univ, Maastricht, Netherlands.
   [Deenik, Jeroen] GGz Centraal, Amersfoort, Netherlands.
   [Swildens, Wilma Elisabeth; Cahn, Wiepke] Altrecht Mental Hlth Inst, Utrecht, Netherlands.
   [Swildens, Wilma Elisabeth; van Meijel, Berno] Inholland Univ Appl Sci, Amsterdam, Netherlands.
   [van Meijel, Berno] Amsterdam Publ Hlth Res Inst, Amsterdam UMC VUmc, Amsterdam, Netherlands.
   [van Meijel, Berno] Parnassia Psychiat & Nstitute, The Hague, Netherlands.
   [Staal, Wouter] Leiden Univ, Leiden, Netherlands.
   [Staal, Wouter] RadboudUMC, Nijmegen, Netherlands.
   [Jorg, Frederike] Univ Med Ctr Groningen, Groningen, Netherlands.
C3 Utrecht University; Utrecht University Medical Center; Utrecht
   University; Maastricht University; Vrije Universiteit Amsterdam; Leiden
   University; Leiden University - Excl LUMC; Radboud University Nijmegen;
   University of Groningen
RP van de Meent, IHT (corresponding author), UMC Utrecht, Utrecht Brain Ctr, Utrecht, Netherlands.; van de Meent, IHT (corresponding author), Univ Utrecht, Utrecht, Netherlands.
EM I.H.T.vandeMeent@umcutrecht.nl
RI van Werkhoven, Henri/F-7915-2013; Staal, W.G./L-4665-2015; Deenik,
   J./ABE-4954-2021; van Dellen, Edwin/AAU-6245-2020; Jörg,
   Frederike/B-1325-2014
OI van Dellen, Edwin/0000-0003-1828-5959; Staal, Wouter/0000-0002-3276-1133
FU governmental funding body NWO [Aut.19.013]; Dutch Heart Association
FX We received funding from the governmental funding body NWO (Aut.19.013).
   We also received funding from the Dutch Heart Association for the
   development of the Muva serious game. NWO and the Dutch Heart
   Association have not and will not participate in the conduct, data
   collection, analysis, and interpretation of this study and will not have
   any role in the decision to submit results for publication.
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NR 51
TC 4
Z9 4
U1 0
U2 9
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-244X
J9 BMC PSYCHIATRY
JI BMC Psychiatry
PD NOV 11
PY 2022
VL 22
IS 1
AR 695
DI 10.1186/s12888-022-04321-3
PG 10
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychiatry
GA 6C4KO
UT WOS:000881985600004
PM 36368947
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Matafome, P
   Nunes, E
   Louro, T
   Amaral, C
   Crisóstomo, J
   Rodrigues, L
   Moedas, AR
   Monteiro, P
   Cipriano, A
   Seiça, R
AF Matafome, P.
   Nunes, E.
   Louro, T.
   Amaral, C.
   Crisostomo, J.
   Rodrigues, L.
   Moedas, A. R.
   Monteiro, P.
   Cipriano, A.
   Seica, R.
TI A role for atorvastatin and insulin combination in protecting from liver
   injury in a model of type 2 diabetes with hyperlipidemia
SO NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
LA English
DT Article
DE Liver; Inflammation; Atorvastatin; Insulin treatment
ID ACID-BINDING PROTEINS; C-REACTIVE PROTEIN; METABOLIC SYNDROME;
   NONALCOHOLIC STEATOHEPATITIS; INFLAMMATORY MARKERS; REDUCTASE
   INHIBITORS; NONDIABETIC PATIENTS; CARDIOVASCULAR RISK; ADIPONECTIN;
   RESISTANCE
AB Non-alcoholic fatty liver disease (NAFLD) is a major complication linked with the metabolic syndrome associated with dyslipidemia, inflammation, and oxidative stress. Impact of type 2 diabetes with hyperlipidemia in NAFLD has to be established, as well as the utility of commonly prescribed anti-diabetic and lipid-lowering agents in improving liver injury markers. Genetic type 2 diabetic Goto-Kakizaki rats were fed with a high-fat diet to test hepatic effects of type 2 diabetes with hyperlipidemia and the effect of atorvastatin and insulin, individually and in combination, in systemic and hepatic inflammatory and oxidative stress markers. High-fat diet aggravated fasting glycemia, systemic and liver lipids, and inflammatory and oxidative stress markers. Individual treatments improved glycemic and lipid profiles, but failed to improve inflammatory markers, whereas insulin was able to reduce liver oxidative stress parameters. Combination of insulin and atorvastatin further improved glycemic and lipid profiles and decreased circulating C-reactive protein levels and liver inflammatory and oxidative stress markers. Insulin and atorvastatin combination leads to better glycaemic and lipid profiles and to better protection against liver inflammation and oxidative stress, giving a superior level of liver protection in type 2 diabetic with hyperlipidemia.
C1 [Matafome, P.; Nunes, E.; Louro, T.; Amaral, C.; Crisostomo, J.; Rodrigues, L.; Moedas, A. R.; Seica, R.] Pole III Univ Coimbra, Fac Med, P-3000354 Coimbra, Portugal.
   [Matafome, P.] Univ Coimbra, Ctr Ophthalmol, Fac Med, P-3000354 Coimbra, Portugal.
   [Matafome, P.; Louro, T.; Amaral, C.; Crisostomo, J.; Rodrigues, L.; Seica, R.] Univ Coimbra, Inst Biomed Res Light & Image, Fac Med, P-3000354 Coimbra, Portugal.
   [Monteiro, P.] Coimbra Univ Hosp & Med Sch, Basic Res Unit Cardiol, Dept Cardiol, Coimbra, Portugal.
   [Cipriano, A.] Coimbra Univ Hosp, Serv Anat Patol, Coimbra, Portugal.
   [Matafome, P.; Nunes, E.; Louro, T.; Amaral, C.; Crisostomo, J.; Rodrigues, L.; Moedas, A. R.; Seica, R.] Univ Coimbra, Inst Physiol, Fac Med, Coimbra, Portugal.
C3 Universidade de Coimbra; Universidade de Coimbra; Universidade de
   Coimbra; Universidade de Coimbra; Centro Hospitalar e Universitario de
   Coimbra (CHUC); Universidade de Coimbra; Centro Hospitalar e
   Universitario de Coimbra (CHUC); Universidade de Coimbra
RP Matafome, P (corresponding author), Pole III Univ Coimbra, Fac Med, Subunit 1,1st Floor, P-3000354 Coimbra, Portugal.
EM paulomatafome@gmail.com
RI Matafome, Paulo/AAQ-4113-2020; Amaral, Carlos/J-4282-2019; Crisóstomo,
   Joana/AAF-3463-2021; Rodrigues, Lisa/T-7772-2018
OI Seica, Raquel/0000-0002-8378-0895; Matafome, Paulo/0000-0002-3422-290X;
   Monteiro, Pedro/0000-0002-6631-207X; Rodrigues,
   Lisa/0000-0001-9898-2409; Crisostomo, Joana/0000-0002-1414-5791
FU University of Coimbra and University Hospitals of Coimbra; SERVIER
   Portugal
FX This work was supported by University of Coimbra and University
   Hospitals of Coimbra. We tank SERVIER Portugal for financial support. We
   thank Prof. Joao Patricio and coworkers (Lurdes Silva, Carlos Silva and
   Jose Pedro Relvao) from the Animal Research Center Laboratory,
   University Hospitals, Coimbra for all the help in maintaining the
   animals. We thank Servico de Patologia Clinica from the University
   Hospital of Coimbra for the technical support. We thank Mario Simoes for
   his technical support.
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NR 47
TC 25
Z9 26
U1 1
U2 7
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0028-1298
EI 1432-1912
J9 N-S ARCH PHARMACOL
JI Naunyn-Schmiedebergs Arch. Pharmacol.
PD MAR
PY 2009
VL 379
IS 3
BP 241
EP 251
DI 10.1007/s00210-008-0363-y
PG 11
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 403DK
UT WOS:000263062400004
PM 18936912
DA 2025-06-11
ER

PT J
AU Duchnowicz, P
   Ziobro, A
   Rapacka, E
   Koter-Michalak, M
   Bukowska, B
AF Duchnowicz, Piotr
   Ziobro, Anna
   Rapacka, Elhbieta
   Koter-Michalak, Maria
   Bukowska, Bozena
TI Changes in Cholinesterase Activity in Blood of Adolescent with Metabolic
   Syndrome after Supplementation with Extract from Aronia
   melanocarpa
SO BIOMED RESEARCH INTERNATIONAL
LA English
DT Article
ID BUTYRYLCHOLINESTERASE ACTIVITY; OXIDATIVE STRESS; BCHE GENE; SERUM
   BUTYRYLCHOLINESTERASE; DIABETES-MELLITUS; ENZYME-ACTIVITY; RISK-FACTORS;
   ACETYLCHOLINESTERASE; PSEUDOCHOLINESTERASE; VARIANTS
AB Obesity and metabolic syndrome (MetS)are growing problems among children and adolescents. There are no reports of changes in the activity of butyrylcholinesterase (BChE) in children and adolescents with metabolic syndrome especially after supplementation with extract from Aronia melanocarpa. Materials studied included plasma and erythrocytes isolated from peripheral blood of patients with MetS and healthy subjects. We have estimated the following parameters: acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) activity, lipid peroxidation and lipids levels in plasma, and erythrocytes membrane. In patients with MetS, a significant increase in AChE and BChE activity, higher LDL-cholesterol and triacylglycerol levels, and lower HDL-cholesterol level were observed. Supplementation with A. melanocarpa extract resulted inmild but statistically significant reduction of total cholesterol, LDL-cholesterol, and triacylglycerol levels and caused an increase in HDL-cholesterol level and a decrease in lipid peroxidation in plasma patients with MetS. Additionally, a decrease in lipid peroxidation and cholesterol level and a decrease in AChE activity in the erythrocyte membranes after supplementation with A. melanocarpa were noted. Summarizing, an increase in AChE and BChE activity and disruption of lipid metabolism in patients with MetS were observed. After supplementation of MetS patients with A. melanocarpa extract, a decrease in AChE activity and oxidative stress was noted.
C1 [Duchnowicz, Piotr; Ziobro, Anna; Koter-Michalak, Maria; Bukowska, Bozena] Univ Lodz, Fac Biol & Environm Protect, Dept Biophys Environm Pollut, Pomorska 141-143 St, PL-91237 Lodz, Poland.
   [Rapacka, Elhbieta] Med Univ Lodz, Interfac Chair Anat & Histol, Dept Normal & Clin Anat, 60 Naturowicza St, PL-90136 Lodz, Poland.
C3 University of Lodz; Medical University Lodz
RP Duchnowicz, P (corresponding author), Univ Lodz, Fac Biol & Environm Protect, Dept Biophys Environm Pollut, Pomorska 141-143 St, PL-91237 Lodz, Poland.
EM piotr.duchnowicz@biol.uni.lodz.pl
RI ; Duchnowicz, Piotr/F-2162-2018
OI Bukowska, Bozena/0000-0003-3044-2953; Duchnowicz,
   Piotr/0000-0002-3514-9716; Rapacka, Elzbieta/0000-0003-4151-7340
FU Medical University of Lodz [502-15-497]; University of Lodz [506/982]
FX This study was supported by the Medical University of Lodz, Grant
   502-15-497, and by the University of Lodz, Grant 506/982.
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NR 56
TC 17
Z9 19
U1 0
U2 10
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2314-6133
EI 2314-6141
J9 BIOMED RES INT
JI Biomed Res. Int.
PY 2018
VL 2018
AR 5670145
DI 10.1155/2018/5670145
PG 8
WC Biotechnology & Applied Microbiology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Research & Experimental Medicine
GA GA5XW
UT WOS:000428408300001
PM 29780825
OA hybrid, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Lombardi, R
   Pisano, G
   Fargion, S
AF Lombardi, Rosa
   Pisano, Giuseppina
   Fargion, Silvia
TI Role of Serum Uric Acid and Ferritin in the Development and Progression
   of NAFLD
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE SUA; liver damage; fibrosis; NASH; serum markers; oxidative stress;
   insulin resistance; metabolic syndrome
ID FATTY LIVER-DISEASE; ENDOPLASMIC-RETICULUM STRESS; METABOLIC SYNDROME;
   INSULIN-RESISTANCE; IRON-METABOLISM; NONALCOHOLIC STEATOHEPATITIS;
   SREBP-1C ACTIVATION; NATIONAL-HEALTH; HEPCIDIN LEVELS; DIETARY IRON
AB Nonalcoholic fatty liver disease (NAFLD), tightly linked to the metabolic syndrome (MS), has emerged as a leading cause of chronic liver disease worldwide. Since it is potentially progressive towards non-alcoholic steatohepatitis (NASH) and hepatic fibrosis, up to cirrhosis and its associated complications, the need for predictive factors of NAFLD and of its advanced forms is mandatory. Despite the current "gold standard" for the assessment of liver damage in NAFLD being liver biopsy, in recent years, several non-invasive tools have been designed as alternatives to histology, of which fibroscan seems the most promising. Among the different serum markers considered, serum uric acid (SUA) and ferritin have emerged as possible predictors of severity of liver damage in NAFLD. In fact, as widely described in this review, they share common pathogenetic pathways and are both associated with hepatic steatosis and MS, thus suggesting a likely synergistic action. Nevertheless, the power of these serum markers seems to be too low if considered alone, suggesting that they should be included in a wider perspective together with other metabolic and biochemical parameters in order to predict liver damage.
C1 [Lombardi, Rosa; Pisano, Giuseppina; Fargion, Silvia] Univ Milan, Ctr Malattie Metabol Fegato, Dept Pathophysiol & Transplantat,Poiliclin Hosp, IRCCS Ca Granda IRCCS Fdn, I-20122 Milan, Italy.
C3 University of Milan
RP Fargion, S (corresponding author), Univ Milan, Ctr Malattie Metabol Fegato, Dept Pathophysiol & Transplantat,Poiliclin Hosp, IRCCS Ca Granda IRCCS Fdn, I-20122 Milan, Italy.
EM rosalombardi@hotmail.it; pinaz81@hotmail.com; silvia.fargion@unimi.it
RI Pisano, Giuseppina/AAB-9234-2019; Lombardi, Rosa/AAB-8031-2019
OI Pisano, Giuseppina/0000-0002-7723-3801; Lombardi,
   Rosa/0000-0001-6958-927X
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NR 85
TC 60
Z9 71
U1 2
U2 20
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD APR
PY 2016
VL 17
IS 4
AR 548
DI 10.3390/ijms17040548
PG 15
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA DK0EL
UT WOS:000374585300127
PM 27077854
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Rajasekar, P
   Viswanathan, P
   Anuradha, CV
AF Rajasekar, P.
   Viswanathan, P.
   Anuradha, C. V.
TI Renoprotective action of L-carnitine in fructose-induced metabolic
   syndrome
SO DIABETES OBESITY & METABOLISM
LA English
DT Article
DE fructose diet; immunostaining; insulin resistance; lipotoxicity;
   oxidative stress; renal damage
ID OXIDATIVE STRESS; ENDOTHELIAL DYSFUNCTION; DIABETIC COMPLICATIONS;
   LIPID-PEROXIDATION; NITRIC-OXIDE; RATS; INACTIVATION; HYPERTENSION;
   DIET; TRIGLYCERIDES
AB Aim: Rats fed high dosage of fructose that form a well-known experimental model of the metabolic syndrome also display progressive renal disturbances. The present study evaluates the influence of L-carnitine (CA) administration on oxidant-antioxidant balance, protein damage and lipid levels in kidney of rats administered high dose of fructose.
   Methods: Adult male Wistar rats were divided into four groups of 10 rats each. Groups I and IV animals received starch-based control diet, while groups II and III rats were fed a high-fructose diet (60 g/100 g). Groups III and IV animals additionally received CA (300 mg/kg/day) for 60 days. The extent of lipid peroxidation, enzymatic and non-enzymatic antioxidants and lipid levels were measured after 60 days. The accumulation of nitrated and oxidatively modified proteins in kidney was also measured by immunohistochemical study with specific antibodies.
   Results: Fructose-fed rats exhibited increased levels of peroxidation end products, diminished antioxidant status, increased staining for the presence of 4-hydroxy-2-nonenal, 2,4-dinitrophenol and 3-nitrotyrosine protein adducts and lipid accumulation in kidney. CA administration attenuated these pathological renal alterations.
   Conclusions: The benefits of CA in this model suggest the therapeutic use of CA to counter the kidney changes associated with metabolic syndrome.
C1 [Rajasekar, P.; Anuradha, C. V.] Annamalai Univ, Dept Biochem & Biotechnol, Annamalainagar 608002, Tamil Nadu, India.
   [Viswanathan, P.] Annamalai Univ, Rajah Muthiah Med Coll, Dept Pathol, Annamalainagar 608002, Tamil Nadu, India.
C3 Annamalai University; Annamalai University; Rajah Muthiah Medical
   College
RP Anuradha, CV (corresponding author), Annamalai Univ, Dept Biochem & Biotechnol, Annamalainagar 608002, Tamil Nadu, India.
EM cvaradha@hotmail.com
RI Venkatraman, Anuradha/U-8717-2019; Panchamoorthy,
   Rajasekar/AAF-1555-2020
OI Carani Venkatraman, Anuradha/0000-0001-9924-2533
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NR 43
TC 23
Z9 24
U1 0
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1462-8902
EI 1463-1326
J9 DIABETES OBES METAB
JI Diabetes Obes. Metab.
PD FEB
PY 2008
VL 10
IS 2
BP 171
EP 180
DI 10.1111/j.1463-1326.2007.00825.x
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 249DD
UT WOS:000252206300008
PM 18093214
DA 2025-06-11
ER

PT J
AU Gallardo-Alfaro, L
   Bibiloni, MD
   Bouzas, C
   Mascaró, CM
   Martínez-González, MA
   Salas-Salvadó, J
   Corella, D
   Schröder, H
   Martínez, JA
   Alonso-Gómez, AM
   Wärnberg, J
   Vioque, J
   Romaguera, D
   Lopez-Miranda, J
   Estruch, R
   Tinahones, FJ
   Lapetra, J
   Serra-Majem, L
   Bueno-Cavanillas, A
   Micó, RM
   Pintó, X
   Gaforio, JJ
   Ortíz-Ramos, M
   Altés-Boronat, A
   Luca, BL
   Daimiel, L
   Ros, E
   Sayon-Orea, C
   Becerra-Tomás, N
   Gimenez-Alba, IM
   Castañer, O
   Abete, I
   Tojal-Sierra, L
   Pérez-López, J
   Torres-Collado, L
   Colom, A
   Garcia-Rios, A
   Castro-Barquero, S
   Bernal, R
   Santos-Lozano, JM
   Fernandez-Lazaro, CI
   Hernández-Alonso, P
   Saiz, C
   Zomeño, MD
   Zulet, MA
   Belló-Mora, MC
   Basterra-Gortari, FJ
   Canudas, S
   Goday, A
   Tur, JA
AF Gallardo-Alfaro, Laura
   del Mar Bibiloni, Maria
   Bouzas, Cristina
   Mascaro, Catalina M.
   Angel Martinez-Gonzalez, Miguel
   Salas-Salvado, Jordi
   Corella, Dolores
   Schroder, Helmut
   Martinez, J. Alfredo
   Alonso-Gomez, Angel M.
   Warnberg, Julia
   Vioque, Jesus
   Romaguera, Dora
   Lopez-Miranda, Jose
   Estruch, Ramon
   Tinahones, Francisco J.
   Lapetra, Jose
   Serra-Majem, Luis
   Bueno-Cavanillas, Aurora
   Mico, Rafael M.
   Pinto, Xavier
   Gaforio, Jose J.
   Ortiz-Ramos, Maria
   Altes-Boronat, Andreu
   Luca, Bogdana L.
   Daimiel, Lidia
   Ros, Emilio
   Sayon-Orea, Carmen
   Becerra-Tomas, Nerea
   Manuel Gimenez-Alba, Ignacio
   Castaner, Olga
   Abete, Itziar
   Tojal-Sierra, Lucas
   Perez-Lopez, Jessica
   Torres-Collado, Laura
   Colom, Antoni
   Garcia-Rios, Antonio
   Castro-Barquero, Sara
   Bernal, Rosa
   Santos-Lozano, Jose Manuel
   Fernandez-Lazaro, Cesar, I
   Hernandez-Alonso, Pablo
   Saiz, Carmen
   Zomeno, Maria Dolors
   Zulet, Maria Angeles
   Bello-Mora, Maria C.
   Javier Basterra-Gortari, F.
   Canudas, Silvia
   Goday, Albert
   Tur, Josep A.
TI Physical activity and metabolic syndrome severity among older adults at
   cardiovascular risk: 1-Year trends
SO NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
LA English
DT Article
DE Metabolic syndrome severity; Physical activity; Mediterranean diet;
   Depression risk; Sedentary behavior; Dietary inflammatory index
ID DOSE-RESPONSE METAANALYSIS; MEDITERRANEAN DIET; INSULIN-RESISTANCE;
   ASSOCIATION; DISEASE; QUESTIONNAIRE; CONSUMPTION; PREVENTION; MORTALITY;
   STRENGTH
AB Background and aims: Modifiable lifestyle factors, such as physical activity (PA) and Mediterranean diet (MD), decrease metabolic syndrome (MetS). The aim was to assess 1-year changes of leisure-time physical activity (LTPA), sedentary behavior, and diet quality according to MetS severity in older population at high cardiovascular risk. Methods and results: Prospective analysis of 55-75-year-old 4359 overweight/obese participants with MetS (PREDIMED-Plus trial) categorized in tertiles according to 1-year changes of a validated MetS severity score (MetSSS). Anthropometrics, visceral adiposity index, triglycerides and glucose index, dietary nutrient intake, biochemical marker levels, dietary inflammatory index, and depression symptoms were measured. Diet quality was assessed by 17-item MD questionnaire. PAs were self-reported using the Minnesota-REGICOR Short Physical Activity Questionnaire and 30-s chair stand test. Sedentary behaviors were measured using the Spanish version of the Nurses' Health Study questionnaire. After 1-year follow-up, decreasing MetSSS was associated with an anti-inflammatory dietary pattern, high intake of vegetables, fruits, legumes, nuts, whole grain cereals, white fish, and bluefish and low intake of refined cereals, red and processed meat, cookies/sweets, and snacks/ready-to-eat-meals. It resulted in high intake of polyunsaturated fatty acids, omega-3 fatty acids, protein, fiber, vitamins B1, B6, B9, C, D, potassium, magnesium, and phosphorus and low glycemic index and saturated fatty acid, trans fatty acid, and carbohydrates intake. Regarding PA and sedentary behavior, decreasing MetSSS was associated with increased moderate-to-vigorous LTPA, chair stand test, and decreased sedentary and TV-viewing time. Conclusion: Decreasing MetSSS was associated with an anti-inflammatory dietary pattern, high LTPA, high MD adherence, low sedentary time, and low depression risk. 2021 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.
C1 [Gallardo-Alfaro, Laura; del Mar Bibiloni, Maria; Bouzas, Cristina; Mascaro, Catalina M.; Angel Martinez-Gonzalez, Miguel; Salas-Salvado, Jordi; Corella, Dolores; Martinez, J. Alfredo; Alonso-Gomez, Angel M.; Warnberg, Julia; Romaguera, Dora; Lopez-Miranda, Jose; Estruch, Ramon; Tinahones, Francisco J.; Lapetra, Jose; Serra-Majem, Luis; Pinto, Xavier; Ros, Emilio; Becerra-Tomas, Nerea; Manuel Gimenez-Alba, Ignacio; Castaner, Olga; Abete, Itziar; Tojal-Sierra, Lucas; Perez-Lopez, Jessica; Colom, Antoni; Garcia-Rios, Antonio; Castro-Barquero, Sara; Bernal, Rosa; Santos-Lozano, Jose Manuel; Hernandez-Alonso, Pablo; Saiz, Carmen; Zomeno, Maria Dolors; Zulet, Maria Angeles; Bello-Mora, Maria C.; Canudas, Silvia; Goday, Albert; Tur, Josep A.] Inst Salud Carlos III ISCIII, CIBER Fisiopatol Obesidad & Nutr CIBEROBN, Madrid 28029, Spain.
   [Gallardo-Alfaro, Laura; del Mar Bibiloni, Maria; Bouzas, Cristina; Mascaro, Catalina M.; Tur, Josep A.] Univ Balearic Isl, Res Grp Community Nutr & Oxidat Stress, Palma De Mallorca 07122, Spain.
   [Gallardo-Alfaro, Laura; del Mar Bibiloni, Maria; Bouzas, Cristina; Mascaro, Catalina M.; Romaguera, Dora; Colom, Antoni; Tur, Josep A.] Hlth Res Inst Balearic Isl IdISBa, Palma De Mallorca 07120, Spain.
   [Angel Martinez-Gonzalez, Miguel; Sayon-Orea, Carmen; Fernandez-Lazaro, Cesar, I; Javier Basterra-Gortari, F.] Univ Navarra, Dept Prevent Med & Publ Hlth, IDISNA, Pamplona 31008, Spain.
   [Angel Martinez-Gonzalez, Miguel] Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA.
   [Salas-Salvado, Jordi; Becerra-Tomas, Nerea; Hernandez-Alonso, Pablo; Canudas, Silvia] Univ Rovira & Virgili, Biochem & Biotechnol Dept, Human Nutr Unit, IISPV,Hosp Univ St Joan, Reus 43201, Spain.
   [Corella, Dolores; Manuel Gimenez-Alba, Ignacio; Saiz, Carmen] Univ Valencia, Dept Prevent Med, Valencia 46100, Spain.
   [Schroder, Helmut; Castaner, Olga; Zomeno, Maria Dolors; Goday, Albert] Inst Hosp Mar Invest Med Municipal Invest Med IMI, Unit Cardiovasc Risk & Nutr, Barcelona 08003, Spain.
   [Schroder, Helmut; Vioque, Jesus; Bueno-Cavanillas, Aurora; Gaforio, Jose J.] Inst Salud Carlos III ISCIII, CIBER Epidemiol & Salud Publ CIBERESP, Madrid 28029, Spain.
   [Martinez, J. Alfredo] CEI UAM CSIC, IMDEA Food, Cardiomet Nutr Program, Madrid 28049, Spain.
   [Martinez, J. Alfredo; Abete, Itziar; Zulet, Maria Angeles] Univ Navarra, Ctr Nutr Res, Dept Nutr Food Sci & Physiol, Pamplona 31008, Spain.
   [Alonso-Gomez, Angel M.; Tojal-Sierra, Lucas; Bello-Mora, Maria C.] Univ Basque Country, Araba Univ Hosp, Bioaraba Hlth Res Inst, Osakidetza Basque Hlth Serv,UPV EHU, Vitoria 48013, Spain.
   [Warnberg, Julia; Perez-Lopez, Jessica] Univ Malaga IBIMA, Sch Hlth Sci, Dept Nursing, Malaga 29071, Spain.
   [Vioque, Jesus; Torres-Collado, Laura] Miguel Hernandez Univ, Inst Invest Sanitaria & Biomed Alicante, ISABIAL UMH, Alicante 46020, Spain.
   [Lopez-Miranda, Jose; Garcia-Rios, Antonio] Univ Cordoba, Rei Sofia Univ Hosp, Maimonides Biomed Res Inst Cordoba IMIBIC, Dept Internal Med,Lipids & Atherosclerosis Unit, Cordoba 14004, Spain.
   [Estruch, Ramon; Castro-Barquero, Sara] Univ Barcelona, Hosp Clin, Dept Internal Med, IDIBAPS, Barcelona 08036, Spain.
   [Tinahones, Francisco J.; Bernal, Rosa] Univ Malaga, Virgen de la Victoria Hosp, Dept Endocrinol, Malaga 29010, Spain.
   [Lapetra, Jose; Santos-Lozano, Jose Manuel] Dist Sanitario Atenc Primaria Sevilla, Res Unit, Dept Family Med, Seville 41013, Spain.
   [Serra-Majem, Luis] Univ Las Palmas Gran Canaria, Inst Biomed Res, Las Palmas Gran Canaria 35016, Spain.
   [Bueno-Cavanillas, Aurora] Univ Granada, Dept Prevent Med, Granada 18071, Spain.
   [Mico, Rafael M.] Inst Salud Carlos III ISCIII, CIBER Diabet & Enfermedades Metab CIBERDEM, Madrid 28029, Spain.
   [Mico, Rafael M.] Univ Leon, Inst Biomed IBIOMED, Leon 24071, Spain.
   [Pinto, Xavier] Hosp Univ Bellvitge, Lipids & Vasc Risk Unit, Internal Med, Barcelona 08907, Spain.
   [Gaforio, Jose J.] Univ Jaen, Ctr Adv Studies Olive Grove & Olive Oils, Dept Hlth Sci, Jaen 23071, Spain.
   [Ortiz-Ramos, Maria] Inst Invest Sanitaria San Carlos IdISSC, Dept Endocrinol & Nutr, Madrid 28040, Spain.
   [Altes-Boronat, Andreu] Univ Barcelona, Hosp Clin, Dept Endocrinol, IDIBAPS, Barcelona 08036, Spain.
   [Luca, Bogdana L.] Fdn Jimenez Diaz, Dept Endocrinol, Madrid 28040, Spain.
   [Daimiel, Lidia] CEI UAM CSIC, Precis Nutr & Obes Program IMDEA Food, Nutr Control Epigenome Grp, Madrid 28049, Spain.
   [Ros, Emilio] Hosp Clin Barcelona, Inst Invest Biomed August Pi Sunyer IDIBAPS, Dept Endocrinol & Nutr, Lipid Clin, Barcelona 08036, Spain.
   [Sayon-Orea, Carmen; Javier Basterra-Gortari, F.] Serv Navarro Salud, Osasunbidea, Pamplona 31003, Spain.
C3 CIBER - Centro de Investigacion Biomedica en Red; CIBEROBN; Universitat
   de les Illes Balears; Institut Investigacio Sanitaria Illes Balears
   (IdISBa); University of Navarra; Harvard University; Harvard T.H. Chan
   School of Public Health; Universitat Rovira i Virgili; Institut
   d'Investigacio Sanitaria Pere Virgili (IISPV); University of Valencia;
   CIBER - Centro de Investigacion Biomedica en Red; CIBERESP; IMDEA Food
   Institute; Consejo Superior de Investigaciones Cientificas (CSIC);
   University of Navarra; University of Basque Country; University Hospital
   of Araba; Bioaraba Health Research Institute; Instituto de Investigacion
   Biomedica de Malaga y Plataforma en Nanomedicina (IBIMA); General
   University Hospital of Alicante; Universidad Miguel Hernandez de Elche;
   Universitat d'Alacant; Instituto de Investigacion Sanitaria y Biomedica
   de Alicante (ISABIAL); Universidad de Cordoba; University of Barcelona;
   Hospital Clinic de Barcelona; IDIBAPS; Universidad de Malaga;
   Universidad de Las Palmas de Gran Canaria; University of Granada; CIBER
   - Centro de Investigacion Biomedica en Red; CIBERDEM; Universidad de
   Leon; University of Barcelona; Institut d'Investigacio Biomedica de
   Bellvitge (IDIBELL); Bellvitge University Hospital; Universidad de Jaen;
   University of Barcelona; Hospital Clinic de Barcelona; IDIBAPS; Consejo
   Superior de Investigaciones Cientificas (CSIC); IMDEA Food Institute;
   University of Barcelona; Hospital Clinic de Barcelona; IDIBAPS; Servicio
   Navarro de Salud - Osasunbidea
RP Tur, JA (corresponding author), Univ Balearic Isl, Res Grp Community Nutr & Oxidat Stress, IDISBA, Guillem Colom Bldg,Campus E-07122, Palma De Mallorca, Spain.; Tur, JA (corresponding author), CIBEROBN, Guillem Colom Bldg,Campus E-07122, Palma De Mallorca, Spain.
EM pep.tur@uib.es
RI Warnberg, Julia/G-1390-2011; Pintó, Xavier/AGI-4297-2022;
   Martinez-Gonzalez, Miguel/AAE-7669-2019; Bouzas, Cristina/AAE-2069-2019;
   Schroder, Helmut/G-2586-2015; Alba, Ignacio/ABI-4663-2020;
   Bueno-Cavanillas, Aurora/O-1513-2015; Tejada, Silvia/L-7297-2014; ALONSO
   GOMEZ, ANGEL/HLG-2476-2023; Martinez, Juan/GXM-4393-2022;
   Fernandez-Lazaro, Cesar/V-6390-2019; Colom Fernandez,
   Antoni/JHU-4849-2023; Romaguera, Dora/ABE-7004-2020; Gallardo-Alfaro,
   Laura/AAB-3363-2021; Corella, Dolores/L-9888-2014; Lopez-Miranda,
   Jose/Y-8306-2019; Vioque, Jesus/A-1066-2008; López,
   Jessica/AAH-2712-2020; Tur, Josep/AAE-5748-2020; Lapetra,
   Jose/F-2552-2015; Castaner, Olga/F-1533-2013; Estruch,
   Ramon/AAZ-3723-2020; Sanchez, Carmen/AAA-4846-2019; Tinahones,
   Francisco/AAB-2882-2020; Ortiz Ramos, María/GYV-2493-2022;
   Salas-Salvado, Jordi/C-7229-2017; Fernandez Garcia, Jose
   Carlos/B-3723-2013; Sayon-Orea, Carmen/A-9828-2017; Canudas,
   Silvia/K-4184-2014; Hernandez-Alonso, Pablo/Q-1090-2018; Becerra-Tomas,
   Nerea/H-3937-2018; Daimiel-Ruiz, Lidia Angeles/M-7779-2014
OI Tinahones, Francisco J/0000-0001-6871-4403; Salas-Salvado,
   Jordi/0000-0003-2700-7459; Ortiz Ramos, Maria/0000-0003-2187-8907;
   Torres-Collado, Laura/0000-0003-2842-1344; Fernandez Garcia, Jose
   Carlos/0000-0003-2308-2865; Sayon-Orea, Carmen/0000-0002-4137-3263;
   Tercero Macia, Cristina/0009-0000-6092-9231; Canudas,
   Silvia/0000-0002-5630-1588; Hernandez-Alonso, Pablo/0000-0002-9977-8976;
   Lopez-Miranda, Jose/0000-0002-8844-0718; Tojal Sierra,
   Lucas/0000-0001-5338-9601; Gimenez Alba, Ignacio
   Manuel/0000-0002-6380-8467; Becerra-Tomas, Nerea/0000-0002-4429-6507;
   Daimiel-Ruiz, Lidia Angeles/0000-0001-9898-6629; Zomeno, M.
   Dolores/0000-0003-1280-7680; Martinez-Gonzalez, Miguel
   A./0000-0002-3917-9808; Vioque, Jesus/0000-0002-2284-148X
FU official funding agency for biomedical research of the Spanish
   government, ISCIII, through the Fondo de Investigacion para la Salud
   (FIS); European Research Council [2013-2018, 340, 918]; Recercaixa
   [2013ACUP00194]; Consejeria de Salud de la Junta de Andalucia
   [PI0458/2013, PS0358/2016, PI0137/2018]; Generalitat Valenciana
   [PROMETEO/2017/017]; SEMERGEN Grant; EU-COST Action [CA16112]; Balearic
   Islands Government; Balearic Islands Health Research Institute (IDISBA);
   ISCIII; European Regional Development Fund [CIBEROBN CB06/03, CB12/03];
   European Commission [EAT2BENICE_H2020_SFS2016]; FPU PhD Grant from the
   Spanish Ministry of Education;  [PI16/00533];  [PI16/00381]; 
   [PI16/00366];  [PI16/01522];  [PI16/01120];  [PI17/00764]; 
   [PI17/01183];  [PI17/00855];  [PI17/01347];  [PI17/00525]; 
   [PI17/01827];  [PI17/00532];  [PI17/00215];  [PI17/01441]; 
   [PI17/00508];  [PI17/01732];  [PI17/00926];  [PI19/00957]; 
   [PI19/00386];  [PI19/00309];  [PI19/01032];  [PI19/00576]; 
   [PI19/00017];  [PI19/01226];  [PI19/00781];  [PI19/01560]; 
   [PI19/01332];  [PI14/01919];  [PI14/00853];  [PI14/01374]; 
   [PI14/00972];  [PI14/00728];  [PI14/01471];  [PI16/00473]; 
   [PI16/00662];  [PI16/01873];  [PI16/01094];  [PI16/00501]; 
   [PI13/00673];  [PI13/00492];  [PI13/00272];  [PI13/01123]; 
   [PI13/00462];  [PI13/00233];  [PI13/02184];  [PI13/00728]; 
   [PI13/01090];  [PI13/01056];  [PI14/01722];  [PI14/00636]; 
   [PI14/00618];  [PI14/00696];  [PI14/01206]
FX The PREDIMED-Plus trial was supported by the official funding agency for
   biomedical research of the Spanish government, ISCIII, through the Fondo
   de Investigacion para la Salud (FIS), which is co-funded by the European
   Regional Development Fund (five coordinated FIS projects led by J.S.-S.
   and J.Vid., including the following projects: PI13/00673, PI13/00492,
   PI13/00272, PI13/01123, PI13/00462, PI13/00233, PI13/02184, PI13/00728,
   PI13/01090, PI13/01056, PI14/01722, PI14/00636, PI14/00618, PI14/00696,
   PI14/01206, PI14/01919, PI14/00853, PI14/01374, PI14/00972, PI14/00728,
   PI14/01471, PI16/00473, PI16/00662, PI16/01873, PI16/01094, PI16/00501,
   PI16/00533, PI16/00381, PI16/00366, PI16/01522, PI16/01120, PI17/00764,
   PI17/01183, PI17/00855, PI17/01347, PI17/00525, PI17/01827, PI17/00532,
   PI17/00215, PI17/01441, PI17/00508, PI17/01732, PI17/00926, PI19/00957,
   PI19/00386, PI19/00309, PI19/01032, PI19/00576, PI19/00017, PI19/01226,
   PI19/00781, PI19/01560, and PI19/01332), the Especial Action Project
   entitled: Implementacion y evaluacion de una intervencion intensive
   sobre la actividad fisica Cohorte PREDIMED-Plus grant to J.S.-S., the
   European Research Council (Advanced Research Grant 2013e2018, 340,918)
   to M.A.M.-G., the Recercaixa Grant to J.S.-S. (2013ACUP00194), Grants
   from the Consejeria de Salud de la Junta de Andalucia (PI0458/2013,
   PS0358/2016, and PI0137/2018), a Grant from the Generalitat Valenciana
   (PROMETEO/2017/017), a SEMERGEN Grant, EU-COST Action CA16112, a Grant
   of support to research groups no. 35/2011 from the Balearic Islands
   Government, Grants (FOLIUM, PRIMUS, SYNERGIA, and LIBERI) from Balearic
   Islands Health Research Institute (IDISBA), funds from the ISCIII and
   the European Regional Development Fund (CIBEROBN CB06/03 and CB12/03)
   and from the European Commission (EAT2BENICE_H2020_SFS2016). Laura
   Gallardo-Alfaro, Catalina M. Mascaro and Ignacio Manuel Gimenez-Alba
   received an FPU PhD Grant from the Spanish Ministry of Education. The
   funding sponsors had no role in the design of the study, in the
   collection, analyses, or interpretation of the data; in the writing of
   the manuscript, and in the decision to publish the results.
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NR 57
TC 11
Z9 12
U1 2
U2 26
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0939-4753
EI 1590-3729
J9 NUTR METAB CARDIOVAS
JI Nutr. Metab. Carbiovasc. Dis.
PD SEP 22
PY 2021
VL 31
IS 10
BP 2870
EP 2886
DI 10.1016/j.numecd.2021.06.015
EA SEP 2021
PG 17
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism; Nutrition
   & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism;
   Nutrition & Dietetics
GA UO5NP
UT WOS:000694742700015
PM 34366176
DA 2025-06-11
ER

PT J
AU Orlando, P
   Silvestri, S
   Bruge, F
   Tiano, L
   Kloting, I
   Falcioni, G
   Polidori, C
AF Orlando, Patrick
   Silvestri, Sonia
   Bruge, Francesca
   Tiano, Luca
   Kloting, Ingrid
   Falcioni, Giancarlo
   Polidori, Carlo
TI High-Fat Diet-Induced Met-Hemoglobin Formation in Rats Prone (WOKW) or
   Resistant (DA) to the Metabolic Syndrome: Effect of CoQ10
   Supplementation
SO BIOFACTORS
LA English
DT Article
DE WistarOttawaKarlsburg W; Dark Agouti; coenzyme Q(10); hemoglobin;
   methemoglobin; oxidative stress; high-fat diet; metabolic syndrome
ID OXIDATIVE STRESS; COENZYME-Q; INSULIN-RESISTANCE; ANTIOXIDANT STATUS;
   ALPHA-TOCOPHEROL; GENERATION; ADIPOSITY; CELLS; YOUNG; Q(10)
AB The aim of this study was to evaluate the effects of a high-fat diet (HFD) on oxidative indexes in WistarOttawaKarlsburg W (WOKW) rats used as a model of metabolic syndrome in comparison with Dark Agouti (DA) rats used as a control strain. This syndrome is defined by the occurrence of two or more risk factors including obesity, hypertension, dyslipidemia, and insulin resistance. Forty rats were used in the study and the effect of HFD was evaluated in terms of body weight and both hemoglobin and CoQ oxidative status. Moreover, 16 rats (8 of each strain) were supplemented with 3 mg/100 g b.w. of CoQ(10) for 1 month in view of its beneficial properties in cardiovascular disease due to its antioxidant activity in the lipid environment. HFD promoted an increase in body weight, in particular in WOKW males, and in the methemoglobin (met-Hb) index in both strains. Moreover, HFD promoted endogenous CoQ(10) oxidation. CoQ(10) supplementation was able to efficiently counteract the HFD pro-oxidant effects, preventing met-Hb formation and CoQ oxidation. (c) 2014 BioFactors, 40(6):603-609, 2014
C1 [Orlando, Patrick; Silvestri, Sonia; Bruge, Francesca; Tiano, Luca] Polytech Univ Marche, Dept Clin & Dent Sci, I-60131 Ancona, AN, Italy.
   [Kloting, Ingrid] Ernst Moritz Arndt Univ Greifswald, Dept Lab Anim Sci, Karlsburg, Germany.
   [Falcioni, Giancarlo; Polidori, Carlo] Univ Camerino, Sch Pharm & Hlth Prod, I-62032 Camerino, Italy.
C3 Marche Polytechnic University; Universitat Greifswald; University of
   Camerino
RP Tiano, L (corresponding author), Polytech Univ Marche, Biochem Sect, DISCO, I-60131 Ancona, AN, Italy.
EM l.tiano@univpm.it
RI Orlando, Patrick/LSJ-0851-2024; Tiano, Luca/ABC-2341-2020
OI Tiano, Luca/0000-0002-7519-7106; Orlando, Patrick/0000-0002-4203-9611;
   Silvestri, Sonia/0000-0003-3302-4335
CR Abdelhalim Mohamed Anwar K, 2010, Pak J Biol Sci, V13, P73
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NR 31
TC 10
Z9 10
U1 0
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0951-6433
EI 1872-8081
J9 BIOFACTORS
JI Biofactors
PD NOV-DEC
PY 2014
VL 40
IS 6
BP 603
EP 609
DI 10.1002/biof.1190
PG 7
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA AX6UC
UT WOS:000347055500006
PM 25428841
DA 2025-06-11
ER

PT J
AU Zhu, H
   Li, YB
AF Zhu, Hong
   Li, Yunbo
TI NAD(P)H:Quinone Oxidoreductase 1 and its Potential Protective Role in
   Cardiovascular Diseases and Related Conditions
SO CARDIOVASCULAR TOXICOLOGY
LA English
DT Article
DE NQO1; Cardiovascular diseases; Gene polymorphisms; Metabolic syndrome;
   Inflammation; Oxidative stress
ID IN-VIVO ROLE; NAD(P)H-QUINONE OXIDOREDUCTASE-1; OXIDATIVE STRESS;
   QUINONE OXIDOREDUCTASE-1; PROTEASOMAL DEGRADATION; SUPEROXIDE SCAVENGER;
   BETA-LAPACHONE; DT-DIAPHORASE; MITOMYCIN-C; NAD(P)H
AB NAD(P)H:quinone oxidoreductase (NQO) represents a family of flavoproteins that catalyze the two-electron reduction of quinones and their derivatives. In mammalian systems, there are two members of NQO, namely, NQO1 and NQO2. NQO1 utilizes NAD(P)H, whereas NQO2 employs dihydronicotinamide riboside (NRH) as the electron donors. In addition to the well-documented action in reducing quinone compounds and preventing the formation of reactive oxygen species, NQO enzymes, especially NQO1 also possess other important biological activities. These include anti-inflammatory effects, direct scavenging of superoxide anion radicals, and stabilization of p53 and other tumor suppressors. Recently, multiple studies in animal models demonstrated a potential role for NQO1 in protecting against cardiovascular injury and related conditions, including atherogenesis, dyslipidemia, and insulin resistance. Functional gene polymorphisms have been identified in human NQO1 gene. Studies on the association between NQO1 gene polymorphisms and susceptibility to disease development also suggested a possible involvement of NQO1 in human cardiovascular diseases and metabolic syndrome. This review is intended to summarize the recent development regarding the biochemical properties and molecular regulation of NQO1 and its potential beneficial role in cardiovascular diseases and related conditions, including metabolic syndrome.
C1 [Zhu, Hong; Li, Yunbo] Virginia Tech, Corp Res Ctr, Edward Via Coll Osteopath Med, Div Biomed Sci, Blacksburg, VA 24060 USA.
   [Zhu, Hong; Li, Yunbo] Virginia Polytech Inst & State Univ, Dept Biomed Sci & Pathobiol, Blacksburg, VA 24060 USA.
   [Li, Yunbo] Wake Forest Univ, Virginia Tech, Sch Biomed Engn & Sci, Blacksburg, VA 24060 USA.
C3 Virginia Polytechnic Institute & State University; Edward Via College of
   Osteopathic Medicine (VCOM); Virginia Polytechnic Institute & State
   University; Wake Forest University; Virginia Polytechnic Institute &
   State University
RP Zhu, H (corresponding author), Virginia Tech, Corp Res Ctr, Edward Via Coll Osteopath Med, Div Biomed Sci, 1861 Pratt Dr, Blacksburg, VA 24060 USA.
EM hzhu@vcom.vt.edu
FU NIH [DK81905, HL93557]
FX This work is supported in part by NIH grants DK81905 (HZ) and HL93557
   (YL).
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NR 39
TC 70
Z9 78
U1 1
U2 18
PU HUMANA PRESS INC
PI TOTOWA
PA 999 RIVERVIEW DRIVE SUITE 208, TOTOWA, NJ 07512 USA
SN 1530-7905
J9 CARDIOVASC TOXICOL
JI Cardiovasc. Toxicol.
PD MAR
PY 2012
VL 12
IS 1
BP 39
EP 45
DI 10.1007/s12012-011-9136-9
PG 7
WC Cardiac & Cardiovascular Systems; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Toxicology
GA 887IC
UT WOS:000299919100004
PM 21818552
DA 2025-06-11
ER

PT J
AU Faugere, M
   Micoulaud-Franchi, JA
   Faget-Agius, C
   Lançon, C
   Cermolacce, M
   Richieri, R
AF Faugere, M.
   Micoulaud-Franchi, J. -A.
   Faget-Agius, C.
   Lancon, C.
   Cermolacce, M.
   Richieri, R.
TI High C-reactive protein levels are associated with depressive symptoms
   in schizophrenia
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE C-reactive protein; Schizophrenia; Depression; Antidepressant; Metabolic
   syndrome
ID COGNITIVE IMPAIRMENT; METABOLIC SYNDROME; PERIPHERAL INFLAMMATION;
   PSYCHOMETRIC PROPERTIES; FRENCH VERSION; SERUM-LEVEL; METAANALYSIS;
   SCALE; CRP; INDIVIDUALS
AB Background: Depressive symptoms are frequently associated with schizophrenia symptoms. C - Reactive protein (CRP), a marker of chronic inflammation, had been found elevated in patients with schizophrenia and in patients with depressive symptoms. However, the association between CRP level and depressive symptoms has been poorly investigated in patients with schizophrenia. The only study conducted found an association between high CRP levels and antidepressant consumption, but not with depressive symptoms investigated with the Calgary Depression Rating Scale for Schizophrenia (CDSS).
   Objectives: The aim of this study was to evaluate CRP levels and depressive symptoms in patients with schizophrenia, and to determine whether high CRP levels are associated with depressive symptoms and/or antidepressant consumption, independently of potential confounding factors, especially tobacco-smoking and metabolic syndrome.
   Methods: Three hundred and seven patients with schizophrenia were enrolled in this study (mean age = 35.74 years, 69.1% male gender). Depressive symptoms was investigated with the CDSS. Patients were classified in two groups: normal CRP level (<= 3.0 mg/L) and high CRP level (> 3.0 mg/L). Current medication was recorded.
   Results: 124 subjects (40.4%) were classified in the high CRP level group. After adjusting for confounding factors, these patients were found to have higher CDSS scores than those with normal CRP levels in multivariate analyses (p = 0.035, OR = 1.067, 95% CI = 1.004-1.132). No significant association between CRP levels and antidepressants consumption was found.
   Limitations: The size sample is relatively small. The cut-off point for high cardiovascular risk was used to define the two groups. CRP was the sole marker of inflammation in this study and was collected at only one time point. The design of this study is cross-sectional and there are no conclusions about the directionality of the association between depression and inflammation in schizophrenia.
   Conclusion: This study found an association between high rates of CRP levels and depressive symptoms in patients with schizophrenia, but no association with antidepressant consumption. Further studies are needed to investigate the impact of inflammation in schizophrenia.
C1 [Faugere, M.; Faget-Agius, C.; Lancon, C.; Richieri, R.] La Conception Univ Hosp, Dept Psychiat, F-13005 Marseille, France.
   [Faugere, M.; Faget-Agius, C.; Lancon, C.; Richieri, R.] Aix Marseille Univ, Self perceived Hlth Assessment Res Unit, EA 3279, F-13005 Marseille, France.
   [Micoulaud-Franchi, J. -A.] Pellegrin Univ Hosp, Sleep Clin, Dept Clin Neurophysiol, F-33076 Bordeaux, France.
   [Micoulaud-Franchi, J. -A.] Bordeaux Univ, USR CNRS SANPSY 3413, Res Unit, F-33000 Bordeaux, France.
   [Cermolacce, M.] St Marguerite Hosp, SHU Adult Psychiat, F-13274 Marseille 9, France.
C3 Aix-Marseille Universite; Aix-Marseille Universite; CHU Bordeaux;
   Universite de Bordeaux; Universite de Bordeaux; Centre National de la
   Recherche Scientifique (CNRS); CNRS - National Institute for Biology
   (INSB)
RP Faugere, M (corresponding author), CHU La Conception, Pole Psychiat Ctr, 147 Bd Baille, F-13005 Marseille, France.
EM melanie.faugere@ap-hm.fr
RI Faugere, Melanie/JCP-3459-2023; richieri, raphaelle/E-4707-2015
OI RICHIERI, Raphaelle/0000-0002-3901-7016; Faugere,
   Melanie/0000-0001-5567-8650; MICOULAUD-FRANCHI,
   Jean-Arthur/0000-0002-5203-8444
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NR 43
TC 28
Z9 31
U1 0
U2 9
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD JAN 1
PY 2018
VL 225
BP 671
EP 675
DI 10.1016/j.jad.2017.09.004
PG 5
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA FK3SF
UT WOS:000413405700094
PM 28917193
DA 2025-06-11
ER

PT J
AU van Velzen, LS
   Schmaal, L
   Milaneschi, Y
   van Tol, MJ
   van der Wee, NJA
   Veltman, DJ
   Penninx, BWJH
AF van Velzen, Laura S.
   Schmaal, Lianne
   Milaneschi, Yuri
   van Tol, Marie-Jose
   van der Wee, Nic J. A.
   Veltman, Dick J.
   Penninx, Brenda W. J. H.
TI Immunometabolic dysregulation is associated with reduced cortical
   thickness of the anterior cingulate cortex
SO BRAIN BEHAVIOR AND IMMUNITY
LA English
DT Article
DE Body mass index; Brain volume; Immunometabolic dysregulation;
   Inflammation; Polygenic risk scores
ID MAJOR DEPRESSIVE DISORDER; C-REACTIVE PROTEIN; METABOLIC SYNDROME;
   BIPOLAR DISORDER; BRAIN STRUCTURE; MATTER VOLUME; STRESS; HIPPOCAMPAL;
   INFLAMMATION; OBESITY
AB Background: Immunometabolic dysregulation (low-grade inflammation and metabolic dysregulation) has been associated with the onset and more severe course of multiple psychiatric disorders, partly due to neuroanatomical changes and impaired neuroplasticity. We examined the effect of multiple markers of immunometabolic dysregulation on hippocampal and amygdala volume and anterior cingulate cortex thickness in a large sample of patients with depression and/or anxiety and healthy subjects (N = 283).
   Methods: Interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-a), c-reactive protein (CRP), triglyceride levels and HDL-cholesterol and genomic profile risk scores (GPRS) for immunometabolic dysregulation were determined in peripheral blood and T1 MRI scans were acquired at 3T. Regional brain volume and cortical thickness was assessed using FreeSurfer. Covariate-adjusted linear regression analyses were performed to examine the relationship between immunometabolic dysregulation and brain volume/ thickness across all subjects.
   Results: Multiple immunometabolic dysregulation markers (i.e. triglyceride levels and inflammation) were associated with lower rostral ACC thickness across all subjects. IL-6 was inversely associated with hippocampal and amygdala volume in healthy subjects only. GPRS for immunometabolic dysregulation were not associated with brain volume or cortical thickness.
   Conclusions: Multiple serum, but not genetic immunometabolic dysregulation markers were found to relate to rostral ACC structure, suggesting that inflammation and metabolic dysregulation may impact the ACC through similar mechanisms. (C) 2016 Elsevier Inc. All rights reserved.
C1 [van Velzen, Laura S.; Schmaal, Lianne; Milaneschi, Yuri; Veltman, Dick J.; Penninx, Brenda W. J. H.] Vrije Univ Amsterdam, Med Ctr, Dept Psychiat & Neurosci, Campus Amsterdam, Amsterdam, Netherlands.
   [van Velzen, Laura S.; Schmaal, Lianne; Milaneschi, Yuri; Veltman, Dick J.; Penninx, Brenda W. J. H.] GGZ InGeest, Amsterdam, Netherlands.
   [van Tol, Marie-Jose] Univ Groningen, Univ Med Ctr Groningen, Dept Neurosci, Sect Cognit Neuropsychiat, Groningen, Netherlands.
   [van der Wee, Nic J. A.] Leiden Univ, Inst Psychiat, Leiden, Netherlands.
   [van der Wee, Nic J. A.] Leiden Univ, LIBC, Leiden, Netherlands.
   [Penninx, Brenda W. J. H.] Vrije Univ Amsterdam, Med Ctr, Dept Psychiat, Amsterdam, Netherlands.
   [Penninx, Brenda W. J. H.] Vrije Univ Amsterdam, Med Ctr, EMGO Inst Hlth & Care Res, Amsterdam, Netherlands.
C3 Vrije Universiteit Amsterdam; University of Groningen; Leiden University
   - Excl LUMC; Leiden University; Leiden University; Leiden University -
   Excl LUMC; Vrije Universiteit Amsterdam; Vrije Universiteit Amsterdam
RP van Velzen, LS (corresponding author), Vrije Univ Amsterdam, Med Ctr, GGZ InGeest, Dept Psychiat, POB 74077, NL-1070 BB Amsterdam, Netherlands.
EM l.vanvelzen@ggzingeest.nl
RI Penninx, Brenda/S-7627-2017; van Harmelen, Anne-Laura/AGH-9307-2022;
   Walter, Henrik/O-2612-2013
OI van Tol, Marie-Jose/0000-0002-9260-5490; Schmaal,
   Lianne/0000-0001-9822-048X; Milaneschi, Yuri/0000-0002-3697-6617
FU Geestkracht program of the Netherlands Organization for Health Research
   and Development (Zon-Mw) [10-000-1002]; VU University Medical Center;
   GGZ inGeest; Arkin; Leiden University Medical Center; GGZ Rivierduinen;
   University Medical Center Groningen; Lentis; GGZ Friesland; GGZ Drenthe;
   Institute for Quality of Health Care (IQ Healthcare); Netherlands
   Institute for Health Services Research (NIVEL); Netherlands Institute of
   Mental Health and Addiction (Trimbos); NWO VICI grant [91811602];
   Netherlands Brain Foundation [F2014(1)-24]; NWO VENI grant [016.156.077]
FX This work was supported by the Geestkracht program of the Netherlands
   Organization for Health Research and Development (Zon-Mw, Grant No.
   10-000-1002) and is also supported by participating universities and
   mental health care organizations (VU University Medical Center, GGZ
   inGeest, Arkin, Leiden University Medical Center, GGZ Rivierduinen,
   University Medical Center Groningen, Lentis, GGZ Friesland, GGZ Drenthe,
   Institute for Quality of Health Care (IQ Healthcare), Netherlands
   Institute for Health Services Research (NIVEL) and Netherlands Institute
   of Mental Health and Addiction (Trimbos). LvV, LS and BWJHP are
   supported by NWO VICI grant (number 91811602). LS is supported by The
   Netherlands Brain Foundation Grant No. (F2014(1)-24). MJvT is supported
   by NWO VENI grant (number 016.156.077)
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NR 66
TC 28
Z9 32
U1 0
U2 17
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0889-1591
EI 1090-2139
J9 BRAIN BEHAV IMMUN
JI Brain Behav. Immun.
PD FEB
PY 2017
VL 60
BP 361
EP 368
DI 10.1016/j.bbi.2016.10.019
PG 8
WC Immunology; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Immunology; Neurosciences & Neurology; Psychiatry
GA EH6UA
UT WOS:000391908200036
PM 27989860
DA 2025-06-11
ER

PT J
AU Mlinar, B
   Marc, J
AF Mlinar, Barbara
   Marc, Janja
TI New insights into adipose tissue dysfunction in insulin resistance
SO CLINICAL CHEMISTRY AND LABORATORY MEDICINE
LA English
DT Review
DE endoplasmic reticulum stress; fibrosis; hypoxia; inflammation; metabolic
   syndrome; obesity; oxidative stress
ID ENDOPLASMIC-RETICULUM STRESS; POLYCYSTIC-OVARY-SYNDROME; FACTOR-KAPPA-B;
   GLYCATION END-PRODUCTS; FATTY-ACID-METABOLISM; TUMOR-NECROSIS-FACTOR;
   OXIDATIVE STRESS; DIABETES-MELLITUS; HUMAN ADIPOCYTES; MITOCHONDRIAL
   DYSFUNCTION
AB In a state of caloric excess, adipose tissue plays an essential role by storing lipids. Its expandability determines the onset of metabolic syndrome (central obesity, dyslipidemia, glucose intolerance and hypertension). When the adipocyte endoplasmic reticulum is no longer capable of processing the excess nutrients, the so-called "endoplasmic reticulum stress" develops. This triggers efflux of free fatty acids from adipocytes into the circulation and causes triglyceride overload in skeletal muscle, liver and pancreas. Adipose tissue hypoxia then develops, due to the failure of vasculature to expand with adipocyte hypertrophy. Increased catabolism in mitochondria leads there to oxidative stress. Both phenomena cause deranged adipokine secretion and low-grade inflammation. Inflammatory cytokines, reactive oxygen species and ectopic lipid deposition are the main mediators of insulin resistance and vascular impairment, which both lead finally to diabetes type 2 and cardiovascular disease. Recently, fibrosis of adipose tissue was also demonstrated in obesity, contributing to the interplay of deleterious factors forcing inflammation. The present paper reviews recent evidence for adipose tissue dysfunction, trying to define causes and consequences. In conclusion, insulin resistance and associated complications originate from excess lipids, which cannot be stored without limit in adipose tissue, thus affecting its integrity and adipokine secretion.
C1 [Mlinar, Barbara; Marc, Janja] Univ Ljubljana, Fac Pharm, Dept Clin Biochem, Ljubljana 1000, Slovenia.
C3 University of Ljubljana
RP Mlinar, B (corresponding author), Univ Ljubljana, Fac Pharm, Dept Clin Biochem, Askerceva 7, Ljubljana 1000, Slovenia.
EM barbi.mlinar@gmail.com
OI marc, janja/0000-0001-6013-9758
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NR 90
TC 59
Z9 64
U1 3
U2 26
PU WALTER DE GRUYTER GMBH
PI BERLIN
PA GENTHINER STRASSE 13, D-10785 BERLIN, GERMANY
SN 1434-6621
J9 CLIN CHEM LAB MED
JI Clin. Chem. Lab. Med.
PY 2011
VL 49
IS 12
BP 1925
EP 1935
DI 10.1515/CCLM.2011.697
PG 11
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA 886LU
UT WOS:000299856700002
PM 21892913
DA 2025-06-11
ER

PT J
AU Dong, LZ
   Qin, C
   Li, Y
   Wu, ZF
   Liu, LL
AF Dong, Lezhen
   Qin, Chuan
   Li, Ying
   Wu, Zufang
   Liu, Lianliang
TI Oat phenolic compounds regulate metabolic syndrome in high fat diet-fed
   mice via gut microbiota
SO FOOD BIOSCIENCE
LA English
DT Article
DE Oat phenolic compounds; HFD-fed mice; Metabolic syndrome; Oxidative
   stress; Glycolipid metabolism; Gut microbiota
ID HEALTH; HYPERGLYCEMIA; IMPROVEMENT; BENEFITS; BARLEY; GRAINS; FIBER
AB This study aimed to better understand the beneficial effect of oat phenolic compounds (OPC) in improving metabolic syndrome via regulating metabolites and gut microbiota composition. The oral administration of OPC can alleviate a range of metabolic syndromes in mice caused by high-fat dietary feeding, such as weight gain, glucose intolerance, elevated serum lipid levels (TC, TG, HDL-C, and LDL-C) and oxidative stress (GSH-Px, T -AOC, SOD and MDA) as well as adipocyte hypertrophy. Besides, OPC-treated mice also have reduced chronic inflammation, which indicates that OPC can interfere with the expression of genes related to glycolipid meta-bolism. Furthermore, HFD-fed mice can cause an imbalance in gut microbiota, while the addition of OPC can improve this negative effect, which also further demonstrated the importance of gut microbiota in the regulation of metabolic disorders. The OPC significantly increased the abundance of Bacteroidetes and reduced the diversity of Firmicutes (p < 0.05) compared with the HFD-fed mice. OPC treatment rebuilt gut microbiota composition via increasing Eubacterium levels and reducing numbers of Alistipes and Lachnospiraceae NK4A136 groups in HFD-fed mice. This result also provided a potential explanation for polyphenols benefit from whole grains in glycolipid metabolism disorders.
C1 [Dong, Lezhen; Qin, Chuan; Li, Ying; Wu, Zufang; Liu, Lianliang] Ningbo Univ, Sch Food & Pharmaceut Sci, State Key Lab Managing Biot & Chem Threats Qual &, Key Lab Anim Prot Deep Proc Technol Zhejiang, Ningbo, Zhejiang, Peoples R China.
C3 Ningbo University
RP Liu, LL (corresponding author), Ningbo Univ, Sch Food & Pharmaceut Sci, State Key Lab Managing Biot & Chem Threats Qual &, Key Lab Anim Prot Deep Proc Technol Zhejiang, Ningbo, Zhejiang, Peoples R China.
EM hahaliang408@126.com
RI Liu, Lianliang/AGN-3565-2022
OI Liu, Lianliang/0000-0003-2693-4824
FU National Natural Science Foundation of China [31601476]; Zhejiang
   Provincial Natural Science Foundation [LY21C200005]
FX Acknowledgements The authors declare no conflict of interest in the
   research. The work was supported by National Natural Science Foundation
   of China (31601476) , Zhejiang Provincial Natural Science Foundation
   (LY21C200005) .
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NR 35
TC 70
Z9 72
U1 28
U2 200
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2212-4292
EI 2212-4306
J9 FOOD BIOSCI
JI Food Biosci.
PD DEC
PY 2022
VL 50
AR 101946
DI 10.1016/j.fbio.2022.101946
EA AUG 2022
PN A
PG 8
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA 5S3BH
UT WOS:000875069400006
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Vossen, ARJV
   van der Zee, HH
   Onderdijk, AJ
   Boer, J
   Prens, EP
AF Vossen, Allard R. J. V.
   van der Zee, Hessel H.
   Onderdijk, Armanda J.
   Boer, Jurr
   Prens, Errol P.
TI Hidradenitis suppurativa is not associated with the metabolic syndrome
   based on body type: A cross-sectional study
SO JOURNAL OF DERMATOLOGY
LA English
DT Article
DE acne inversa; body mass index; mechanical stress; metabolic syndrome;
   waist-to-hip ratio
ID CARDIOVASCULAR EVENTS; WAIST CIRCUMFERENCE; MECHANICAL-STRESS; OBESITY;
   PREVALENCE; MORTALITY; DISEASE; RISK; PATHOPHYSIOLOGY; INFLAMMATION
AB A body type with a high waist circumference or elevated waist-to-hip ratio (WHR), known as the apple body type, represents central/visceral obesity and is associated with the metabolic syndrome. The aim of this study was to simultaneously investigate the body mass index (BMI) and WHR in order to classify body types in individuals with hidradenitis suppurativa (HS) compared with a general dermatological population. A hospital-based cross-sectional study was performed in the Netherlands. One hundred and six HS patients and 212 controls were included. The BMI was significantly higher in the HS group in comparison with the control group, at 27.8 +/- 5.4 and 25.6 +/- 4.8, respectively (P < 0.001). The WHR did not significantly differ between HS patients and the control dermatological population (P > 0.05). A more peripheral pattern of bodyweight distribution was seen in 43% of the 37 obese HS individuals, in contrast to 19% of 31 obese patients in the control group (P = 0.036). In conclusion, the body type in obese HS patients, based on the WHR, shows a more peripheral pattern and differs from the WHR in the BMI-matched general dermatological population.
C1 [Vossen, Allard R. J. V.; van der Zee, Hessel H.; Onderdijk, Armanda J.; Prens, Errol P.] Erasmus MC, Dept Dermatol, Burgemeesters Jacobplein 51, NL-3015 CA Rotterdam, Netherlands.
   [Boer, Jurr] Deventer Hosp, Dept Dermatol, Deventer, Netherlands.
C3 Erasmus University Rotterdam; Erasmus MC; Deventer Hospital
RP Vossen, ARJV (corresponding author), Erasmus MC, Dept Dermatol, Burgemeesters Jacobplein 51, NL-3015 CA Rotterdam, Netherlands.
EM a.vossen@erasmusmc.nl
OI van der zee, HH/0000-0002-2874-7726
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NR 37
TC 9
Z9 9
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0385-2407
EI 1346-8138
J9 J DERMATOL
JI J. Dermatol.
PD FEB
PY 2017
VL 44
IS 2
BP 154
EP 159
DI 10.1111/1346-8138.13572
PG 6
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA EL7ZJ
UT WOS:000394839500007
PM 27608328
DA 2025-06-11
ER

PT J
AU Marycz, K
   Houston, MI
   Weiss, C
   Röcken, M
   Kornicka, K
AF Marycz, K.
   Houston, M. Irwin
   Weiss, C.
   Roecken, M.
   Kornicka, K.
TI 5-Azacytidine and Resveratrol Enhance Chondrogenic Differentiation of
   Metabolic Syndrome-Derived Mesenchymal Stem Cells by Modulating
   Autophagy
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Article
AB Recently, metabolic syndrome (MS) has gained attention in human and animal metabolic medicine. Insulin resistance, inflammation, hyperleptinemia, and hyperinsulinemia are critical to its definition. MS is a complex cluster of metabolic risk factors that together exert a wide range of effects on multiple organs, tissues, and cells in the body. Adipose stem cells (ASCs) are multipotent stem cell population residing within the adipose tissue that is inflamed during MS. Studies have indicated that these cells lose their stemness and multipotency during MS, which strongly reduces their therapeutic potential. They suffer from oxidative stress, apoptosis, and mitochondrial deterioration. Thus, the aim of this study was to rejuvenate these cells in vitro in order to improve their chondrogenic differentiation effectiveness. Pharmacotherapy of ASCs was based on resveratrol and 5-azacytidine pretreatment. We evaluated whether those substances are able to reverse aged phenotype of metabolic syndrome-derived ASCs and improve their chondrogenic differentiation at its early stage using immunofluorescence, transmission and scanning electron microscopy, real-time PCR, and flow cytometry. Obtained results indicated that 5-azacytidine and resveratrol modulated mitochondrial dynamics, autophagy, and ER stress, leading to the enhancement of chondrogenesis in metabolically impaired ASCs. Therefore, pretreatment of these cells with 5-azacytidine and resveratrol may become a necessary intervention before clinical application of these cells in order to strengthen their multipotency and therapeutic potential.
C1 [Marycz, K.; Kornicka, K.] Wroclaw Univ Environm & Life Sci, Dept Expt Biol, PL-50375 Wroclaw, Poland.
   [Marycz, K.; Kornicka, K.] Int Inst Translat Med, Jesionowa 11, PL-55114 Wisznia Mala, Poland.
   [Marycz, K.; Houston, M. Irwin; Weiss, C.] PferdePraxis Dr Med Vet Daniel Weiss, Postmatte 14, CH-8807 Freienbach, Switzerland.
   [Roecken, M.] Justus Liebig Univ, Equine Clin Equine Surg, Fac Vet Med, D-35392 Giessen, Germany.
C3 Wroclaw University of Environmental & Life Sciences; Justus Liebig
   University Giessen
RP Marycz, K; Kornicka, K (corresponding author), Wroclaw Univ Environm & Life Sci, Dept Expt Biol, PL-50375 Wroclaw, Poland.; Marycz, K; Kornicka, K (corresponding author), Int Inst Translat Med, Jesionowa 11, PL-55114 Wisznia Mala, Poland.; Marycz, K (corresponding author), PferdePraxis Dr Med Vet Daniel Weiss, Postmatte 14, CH-8807 Freienbach, Switzerland.
EM krzysztofmarycz@interia.pl; kornicka.katarzyna@gmail.com
FU National Science Centre in Poland [2016/21/B/NZ7/01111]
FX This project is financed in the framework of grant entitled "Modulation
   mitochondrial metabolism and dynamics and targeting DNA methylation of
   adipose-derived mesenchymal stromal stem cell (ASC) using resveratrol
   and 5-azacytydin as a therapeutic strategy in the course of equine
   metabolic syndrome (EMS)" (grant no. 2016/21/B/NZ7/01111) financed by
   the National Science Centre in Poland. We would like to thank Dr Jakub
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NR 59
TC 14
Z9 15
U1 0
U2 3
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PY 2019
VL 2019
AR 1523140
DI 10.1155/2019/1523140
PG 20
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA IA0MC
UT WOS:000469249700001
PM 31214275
OA Green Published, Green Submitted, hybrid
DA 2025-06-11
ER

PT J
AU Kim, EY
   Kim, SH
   Ha, K
   Lee, HJ
   Yoon, DH
   Ahn, YM
AF Kim, Eun Young
   Kim, Se Hyun
   Ha, Kyooseob
   Lee, Hyun Jeong
   Yoon, Dae Hyun
   Ahn, Yong Min
TI Depression trajectories and the association with metabolic adversities
   among the middle-aged adults
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Depressive trajectory; Metabolic syndrome; Life-style factors; Gender;
   Middle-aged
ID LONGITUDINAL CANADIAN COHORT; MAJOR DEPRESSION; HYPERCORTISOLEMIC
   DEPRESSION; PSYCHOLOGICAL DISTRESS; ALCOHOL-CONSUMPTION; GLOBAL BURDEN;
   YOUNG-ADULTS; RISK-FACTOR; SYMPTOMS; HEALTH
AB Background: Despite both depression and metabolic disturbances confer substantial burden of disease, natural course of depressive symptoms and the relationship with metabolic adversities have not examined. We explore associations between trajectories of depressive symptoms and metabolic disturbance, lifestyle factors and comorbidities.
   Methods: This retrospective cohort study included 13,745 subjects (8113 men and 5632 women) 40-59 years of age who underwent health examinations at the Seoul National University Hospital Healthcare System, Gangnam Center, in Korea. The median follow-up duration was 4.0 years. We estimated the mean trajectories of the Beck Depression Inventory scores using latent-class growth-curve analysis.
   Results: We identified four distinctive trajectories of depressive symptoms in both sex. The probabilities of group membership were 35.1% (n=2374) in minimal, 47.4% (n=4545) in persistent-mild, 14.4% (n=987) in persistent-moderate, and 3.0% (n=207) in persistent-severe in men, and 36.3% (n=1883), 50.0% (n=3069),12.3% (n=601) and 1.5% (n=79) in women. We found significant increasing trend in the prevalence of metabolic abnormalities in more severe depressive trajectory. The adjusted odds ratios of persistent-severe were significantly increased for the following variables: low HDL, hypertriglyceridemia, and metabolic syndrome (MetS) in men and hypertriglyceridemia, MetS in women, and smoking, alcohol consumption and lack of exercise in both genders.
   Limitations: Medical and psychiatric histories were obtained using a self-reported questionnaire rather than formal diagnostic assessments.
   Conclusions: The higher level of depressive symptoms trajectory was associated with MetS, especially lipid abnormalities, and several modifiable lifestyle factors. Our findings provide important implications for developing health policy and guidelines for reducing depressive symptom burden. 2015 Elsevier B.V. All rights reserved.
C1 [Kim, Eun Young] Natl Canc Ctr, Mental Hlth Clin, Goyang, South Korea.
   [Kim, Se Hyun] Dongguk Univ, Int Hosp, Sch Med, Dept Neuropsychiat, Goyang, South Korea.
   [Ha, Kyooseob; Lee, Hyun Jeong] Seoul Natl Univ, Bundang Hosp, Dept Psychiat, Songnam, South Korea.
   [Ha, Kyooseob] Seoul Natl Hosp, Seoul, South Korea.
   [Yoon, Dae Hyun] Seoul Natl Univ Hosp, Healthcare Syst Gangnam Ctr, Dept Psychiat, Seoul, South Korea.
   [Ahn, Yong Min] Seoul Natl Univ, Coll Med, Inst Human Behav Med, Seoul 110744, South Korea.
C3 National Cancer Center - Korea (NCC); Dongguk University; Seoul National
   University (SNU); Seoul National University (SNU); Seoul National
   University Hospital; Seoul National University (SNU)
RP Ahn, YM (corresponding author), Seoul Natl Univ, Coll Med, Inst Human Behav Med, Dept Psychiat & Behav Sci, 28 Yongon Dong, Seoul 110744, South Korea.
EM dhyoon@snuh.org; aym@snu.ac.kr
RI Ha, Kyooseob/J-5698-2012; Kim, Kyung/F-3470-2010; Yoon, Dae/C-4302-2013
OI Ha, Kyooseob/0000-0001-5035-2950
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NR 44
TC 20
Z9 23
U1 1
U2 17
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD DEC 1
PY 2015
VL 188
BP 14
EP 21
DI 10.1016/j.jad.2015.08.024
PG 8
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA CV3OI
UT WOS:000364168100002
PM 26340078
DA 2025-06-11
ER

PT J
AU Cardozo, CML
   Inada, AC
   Marcelino, G
   Figueiredo, PS
   Arakaki, DG
   Hiane, PA
   Cardoso, CAL
   Guimaraes, RDA
   Freitas, KD
AF Lopes Cardozo, Carla Maiara
   Inada, Aline Carla
   Marcelino, Gabriela
   Figueiredo, Priscila Silva
   Arakaki, Daniela Granja
   Hiane, Priscila Aiko
   Lima Cardoso, Claudia Andrea
   Avellaneda Guimaraes, Rita de Cassia
   Freitas, Karine de Cassia
TI Therapeutic Potential of Brazilian Cerrado Campomanesia Species
   on Metabolic Dysfunctions
SO MOLECULES
LA English
DT Review
DE Campomanesia species; medicinal plants; Brazilian Cerrado;
   obesity-induced metabolic syndrome
ID OXIDATIVE STRESS; ESSENTIAL OIL; O. BERG; TOXICOLOGICAL ANALYSIS;
   ANTIOXIDANT ACTIVITY; XANTHOCARPA BERG.; MEDICINAL-PLANTS;
   ADIPOSE-TISSUE; OBESITY; FRUITS
AB Obesity, in conjunction with other metabolic disorders such as insulin resistance and dyslipidemia, is a feature of metabolic syndrome which is characterized by a pro-inflammatory state and increased oxidative stress. Therefore, antioxidant foods are proposed to prevent and treat these disorders. Medicinal plants are one of the main strategies in this regard. Guavira, a Brazilian Cerrado plant, contains different bioactive compounds with a high antioxidant capacity and without clinical or reproductive toxicity effects. Though there are different varieties of guavira, the principal Brazilian Cerrado guaviras demonstrated hypoglycemic, anti-inflammatory, and hypocholesterolemic actions. There is also a potential antiplatelet agent in C. xanthocarpa, while C. adamantium displayed hypocholesterolemic actions in animal models and human clinical trials. On the other hand, even with a lack of studies related to C. pubescens, it demonstrated anti-inflammatory effects and an antioxidant capacity in in vitro studies. Despite the fact that most of the studies were not performed to evaluate pathological conditions specific to obese animal models or obese subjects, guavira demonstrated effects in metabolic disorders that are commonly related to the obesity context, such as cardiovascular disturbances and hyperglycemia status. This suggests that guavira is a potential therapeutic approach to obesity-induced metabolic syndrome.
C1 [Lopes Cardozo, Carla Maiara; Inada, Aline Carla; Marcelino, Gabriela; Figueiredo, Priscila Silva; Arakaki, Daniela Granja; Hiane, Priscila Aiko; Avellaneda Guimaraes, Rita de Cassia; Freitas, Karine de Cassia] Fed Univ Mato Grosso do Sul UFMS, Post Grad Program Hlth & Dev Cent West Reg Brazil, BR-79070900 Campo Grande, MS, Brazil.
   [Lima Cardoso, Claudia Andrea] Univ Estadual Mato Grosso do Sul, Fac Chem, Res Ctr Biodivers, BR-79804970 Dourados, MS, Brazil.
C3 Universidade Federal de Mato Grosso do Sul; Universidade Estadual de
   Mato Grosso do Sul
RP Freitas, KD (corresponding author), Fed Univ Mato Grosso do Sul UFMS, Post Grad Program Hlth & Dev Cent West Reg Brazil, BR-79070900 Campo Grande, MS, Brazil.
EM carlinhalopescardozo@hotmail.com; inadaaline@gmail.com;
   gabi19ac@gmail.com; pri.figueiredo92@gmail.com; daniarakaki@gmail.com;
   priscila.hiane@ufms.br; claudia@uems.br; ritaaguimaraes@gmail.com;
   kcfreitas@gmail.com
RI Figueiredo, Priscila/JBS-1673-2023; Cardoso, Claudia/AAK-5578-2020;
   Guimarães, Rita de Cássia/JVO-6281-2024
OI Marcelino, Gabriela/0000-0003-0015-6083; Cardoso, Claudia Andrea
   Lima/0000-0002-4907-0056; Inada, Aline/0000-0001-6788-9172
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NR 91
TC 13
Z9 13
U1 0
U2 17
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1420-3049
J9 MOLECULES
JI Molecules
PD SEP
PY 2018
VL 23
IS 9
AR 2336
DI 10.3390/molecules23092336
PG 17
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA GW9YP
UT WOS:000447365100247
PM 30216974
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Debin, R
   Lauzier, B
   Sicard, P
   Delemasure, S
   Amoureux, S
   Duvillard, L
   Vergely, C
   Cottin, Y
   Rochette, L
AF Debin, Regine
   Lauzier, Benjamin
   Sicard, Pierre
   Delemasure, Stephanie
   Amoureux, Sebastien
   Duvillard, Laurence
   Vergely, Catherine
   Cottin, Yves
   Rochette, Luc
TI Are Zucker obese rats a useful model for cardiovascular complications in
   metabolic syndrome? Physical, biochemical and oxidative stress
   considerations
SO FUNDAMENTAL & CLINICAL PHARMACOLOGY
LA English
DT Article
DE coronary reactivity; electron paramagnetic resonance; ischemia; isolated
   heart; metabolic syndrome; Zucker rats
ID INSULIN-RESISTANCE; HEART-DISEASE; SUPEROXIDE; PREVALENCE; PLASMA
AB We wondered if Zucker obese (ZO) rats would be a good experimental model to evaluate cardiovascular complications of metabolic syndrome ( MS). ZO rats were compared with both their littermate controls, Zucker lean (ZL) rats and to Wistar rats (reference strain). We designed this work:(i) to measure certain physical and biochemical characteristics of MS; (ii) to evaluate coronary and cardiac function in isolated conditions and after ischemia; and (iii) to study plasma and heart tissue oxidative stress markers. In vivo, ZO rats had higher levels of plasma glucose, cholesterol and triglycerides than their ZL littermates, but there was no difference between the groups for systolic arterial blood pressure and heart rate. In vitro, coronary endothelial function was notably impaired in ZO and ZL rats. After global ischemia, the worse ventricular recovery in ZO and ZL rats was associated with arrhythmias during reperfusion. We detected similar levels of plasma ascorbyle free radical, oxygen radical absorbance capacity and vitamin C concentrations in the three groups. Dihydroethidium staining showed higher superoxide production in the coronary vessels of ZO rats than in ZL and Wistar rats. Our results show that ZO might only correspond to early-stage cardiovascular complications associated with MS.
C1 [Debin, Regine; Lauzier, Benjamin; Sicard, Pierre; Delemasure, Stephanie; Amoureux, Sebastien; Vergely, Catherine; Cottin, Yves; Rochette, Luc] Fac Med & Pharm Dijon, IFR 100, Lab Physiopathol & Pharmacol Cardiovasc Expt, F-21079 Dijon, France.
   [Duvillard, Laurence] Hop Bocage, Inst Natl Sante & Rech Med, Unite 498, F-21079 Dijon, France.
   [Cottin, Yves] CHU Dijon, Hop Bocage, Serv Cardiol, F-21034 Dijon, France.
C3 Institut Agro; AgroSup Dijon; Universite Bourgogne Europe; Institut
   National de la Sante et de la Recherche Medicale (Inserm); Universite
   Bourgogne Europe; CHU Dijon Bourgogne; Universite Bourgogne Europe; CHU
   Dijon Bourgogne
RP Vergely, C (corresponding author), Fac Med & Pharm Dijon, IFR 100, Lab Physiopathol & Pharmacol Cardiovasc Expt, 7 Bd Jeanne Arc BP87900, F-21079 Dijon, France.
EM cvergely@u-bourgogne.fr
RI COTTIN, YVES/ABA-4622-2020; Lauzier, Benjamin/D-3570-2015; Sicard,
   Pierre/JCE-3774-2023; VERGELY, CATHERINE/L-9534-2015; Sicard,
   Pierre/N-7310-2018
OI Rochette, Luc/0000-0001-9973-8803; VERGELY,
   CATHERINE/0000-0003-4009-776X; Sicard, Pierre/0000-0001-5837-3916;
   Lauzier, Benjamin/0000-0002-1370-6155
FU Region Bourgogne, and Association de Cardiologie de Bourgogne
FX This work was supported by Region Bourgogne, and Association de
   Cardiologie de Bourgogne. We kindly thank Franck Me ' netrier for the
   histological preparation, and Philip Bastable for the English revision.
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NR 32
TC 7
Z9 8
U1 0
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0767-3981
EI 1472-8206
J9 FUND CLIN PHARMACOL
JI Fundam. Clin. Pharmacol.
PD FEB
PY 2009
VL 23
IS 1
BP 59
EP 67
DI 10.1111/j.1472-8206.2008.00659.x
PG 9
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 421QJ
UT WOS:000264373100007
PM 19267771
OA Bronze, Green Submitted
DA 2025-06-11
ER

PT J
AU Karukivi, M
   Jula, A
   Hutri-Kähönen, N
   Juonala, M
   Raitakari, O
AF Karukivi, Max
   Jula, Antti
   Hutri-Kahonen, Nina
   Juonala, Markus
   Raitakari, Olli
TI Is alexithymia associated with metabolic syndrome? A study in a healthy
   adult population
SO PSYCHIATRY RESEARCH
LA English
DT Article
DE Depression; Emotion; Hypertension; Somatic illness
ID FACTORIAL VALIDITY; SERUM ADIPONECTIN; LIFE-STYLE; SCALE; RISK;
   RELIABILITY; DEPRESSION; IMMUNE
AB Metabolic syndrome (MetS) is a constellation of risk factors for, in particular, cardiovascular diseases and increased mortality, and it constitutes a major clinical challenge affecting millions of lives. Alexithymia is a condition that has been linked with several mental diseases and symptoms, as well as somatic illnesses, including essential hypertension and diabetes mellitus. However, there is limited research on the association of alexithymia and MetS. The aim of the present study was to comprehensively explore this association in a large (n=1648) non-clinical sample of adults. Logistic regression analyses were applied to the five separate MetS components as well as the MetS diagnosis, and the analyses included a number of sociodemographic variables and depressive symptoms as covariates. The results confirmed the previous finding of alexithymic features being independently and significantly associated with hypertension. As a new finding, this association appears to be related to two particular dimensions of alexithymia, namely difficulty describing feelings and externally oriented thinking. Interestingly, alexithymic features were also separately significantly associated with waist circumference and triglycerides as well as the MetS diagnosis. Depressive symptoms did not have any significant effect on the relations of alexithymia and MetS. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
C1 [Karukivi, Max] Univ Turku, Dept Psychiat, Turku, Finland.
   [Karukivi, Max] Satakunta Hosp Dist, Psychiat Care Div, Sairaalantie 14, FI-29200 Harjavalta, Finland.
   [Jula, Antti] Natl Inst Hlth & Welf, Dept Hlth, Turku, Finland.
   [Hutri-Kahonen, Nina] Univ Tampere, Dept Pediat, FIN-33101 Tampere, Finland.
   [Hutri-Kahonen, Nina] Tampere Univ Hosp, Tampere, Finland.
   [Juonala, Markus] Univ Turku, Dept Med, Turku, Finland.
   [Juonala, Markus] Turku Univ Hosp, Div Med, FIN-20520 Turku, Finland.
   [Raitakari, Olli] Univ Turku, Res Ctr Appl & Prevent Cardiovasc Med, Turku, Finland.
   [Raitakari, Olli] Turku Univ Hosp, Dept Clin Physiol & Nucl Med, FIN-20520 Turku, Finland.
C3 University of Turku; Finland National Institute for Health & Welfare;
   Tampere University; Tampere University; Tampere University Hospital;
   University of Turku; University of Turku; University of Turku;
   University of Turku
RP Karukivi, M (corresponding author), Satakunta Hosp Dist, Psychiat Care Div, Sairaalantie 14, FI-29200 Harjavalta, Finland.
EM max.karukivi@utu.fi
RI Raitakari, Olli/AAQ-7389-2021
OI Juonala, Markus/0000-0001-9498-364X; Karukivi, Max/0000-0002-8478-3051
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NR 41
TC 20
Z9 22
U1 0
U2 8
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0165-1781
J9 PSYCHIAT RES
JI Psychiatry Res.
PD FEB 28
PY 2016
VL 236
BP 58
EP 63
DI 10.1016/j.psychres.2015.12.034
PG 6
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA DE8VD
UT WOS:000370913900010
PM 26747214
DA 2025-06-11
ER

PT J
AU Maes, M
   Jirakran, K
   Vasupanrajit, A
   Zhou, B
   Tunvirachaisakul, C
   Almulla, AF
AF Maes, Michael
   Jirakran, Ketsupar
   Vasupanrajit, Asara
   Zhou, Bo
   Tunvirachaisakul, Chavit
   Almulla, Abbas F.
TI Major depressive disorder, neuroticism, suicidal behaviors, and
   depression severity are associated with cytokine networks and their
   intricate interactions with metabolic syndrome
SO JOURNAL OF PSYCHOSOMATIC RESEARCH
LA English
DT Article
DE Major depression; Inflammation; Cytokines; Neuroimmune; Mood disorders;
   Depressive spectrum
ID BIPOLAR DISORDER; INTERFERON-GAMMA; CHEMOKINE CCL2; RATING-SCALE;
   ANTIDEPRESSANTS; SYSTEM; INTERLEUKIN-2; METAANALYSIS; RECEPTOR; ILLNESS
AB Objectives: To identify alterations in the immune profiles in outpatients with major depression (MDD), and its associations with key features, such as suicidal ideation, neuroticism, cognitive symptoms, and the depression phenome while accounting for metabolic syndrome (MetS). Methods: In this case-control study, we assayed 48 serum cytokines, chemokines, and growth factors in 67 healthy controls and 66 MDD outpatients. Around 50 % of the outpatient MDD and control participants had a diagnosis of MetS. Results: Ten differentially expressed proteins (DEPs) were upregulated in outpatient MDD (i.e., CXCL12, tumor necrosis factor [TNF]beta, platelet-derived growth factor [PDGF], CCL11, interleukins [IL]9, IL4, CCL5, CCL2, CCL4, IL1 receptor antagonist [IL1RN]), indicating an immune and defense response. Six DEPs were downregulated (vascular endothelial growth factor A [VEGFA], IL12, CCL3, colony stimulating factor [CSF]1, IL1B, nerve growth factor [NGF]), indicating lowered neurogenesis and neuron death regulation. Significant interactions between outpatient MDD and MetS caused a) substantial increases in IL4, IL17, TNF, TNFB, CCL2, CCL5, PDGF, IL1RN; and b) downregulation of VEGFA and FGF. A large part of the variance in neuroticism (26 %), suicidal behaviors (23 %), and the MDD phenome (31 %) was predicted by immunological data and interactions between MetS and CCL5, TNFB or VEGFA. Conclusion: Outpatient MDD is characterized by a cytokine profile with neurotoxic potential which partly explains neuroticism, suicidal behaviors, and the phenome's severity. Lowered IL-10 and activated cytokine profiles with neurotoxic potential are characteristics of outpatient MDD and other depression phenotypes, including severe first-episode inpatient MDD. The presence of MetS in outpatient MDD considerably activates immune profiles with neurotoxic potential. Consequently, immune studies in MDD should always be performed in subjects with and without MetS.
C1 [Maes, Michael; Zhou, Bo; Almulla, Abbas F.] Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Sichuan Prov Ctr Mental Hlth, Sch Med, Chengdu 610072, Peoples R China.
   [Maes, Michael; Zhou, Bo; Almulla, Abbas F.] Chinese Acad Med Sci, Key Lab Psychosomat Med, Chengdu 610072, Peoples R China.
   [Maes, Michael; Jirakran, Ketsupar; Vasupanrajit, Asara; Tunvirachaisakul, Chavit; Almulla, Abbas F.] Chulalongkorn Univ, Fac Med, Dept Psychiat, Bangkok, Thailand.
   [Maes, Michael; Jirakran, Ketsupar; Vasupanrajit, Asara; Tunvirachaisakul, Chavit] Chulalongkorn Univ, Fac Med, Dept Psychiat, PhD Program Mental Hlth, Bangkok, Thailand.
   [Maes, Michael; Tunvirachaisakul, Chavit] Chulalongkorn Univ, Fac Med, Cognit Impairment & Dementia Res Unit, Bangkok, Thailand.
   [Maes, Michael; Tunvirachaisakul, Chavit] Chulalongkorn Univ, Cognit Fitness & Biopsychol Technol Res Unit, Fac Med, Bangkok 10330, Thailand.
   [Maes, Michael] Med Univ Plovdiv, Dept Psychiat, Plovdiv, Bulgaria.
   [Maes, Michael] Med Univ Plovdiv, Res Inst, Plovdiv, Bulgaria.
   [Maes, Michael] Kyung Hee Univ, 26 Kyungheedae Ro, Seoul 02447, South Korea.
   [Jirakran, Ketsupar] Chulalongkorn Univ, Fac Med, Ctr Excellence Maximizing Childrens Dev Potential, Dept Pediat, Bangkok, Thailand.
   [Almulla, Abbas F.] Islamic Univ, Coll Med Technol, Med Lab Technol Dept, Najaf, Iraq.
C3 University of Electronic Science & Technology of China; Sichuan
   Provincial People's Hospital; Chinese Academy of Medical Sciences -
   Peking Union Medical College; Chulalongkorn University; Chulalongkorn
   University; Chulalongkorn University; Chulalongkorn University; Medical
   University Plovdiv; Medical University Plovdiv; Kyung Hee University;
   Chulalongkorn University; Islamic University College
RP Zhou, B; Almulla, AF (corresponding author), Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Sichuan Prov Ctr Mental Hlth, Sch Med, Chengdu 610072, Peoples R China.
EM tonyac7721@163.com; chavit.t@chula.ac.th;
   abbass.chem.almulla1991@gmail.com
RI Almulla, Abbas F./GPW-6234-2022; Vasupanrajit, Asara/ABG-5437-2021;
   Maes, Michael/B-8546-2011
OI Maes, Michael/0000-0002-2012-871X
FU Ratchadapiseksompotch Fund, Graduate Affairs, Faculty of Medicine,
   Chulalongkorn University [GA64/21]; Graduate School; King Bhumibhol
   Adulyadej's 72nd Birthday Anniversary Scholarship Chulalongkorn
   University; The 100th Anniversary Chulalongkom University Fund for
   Doctoral Scholarship
FX This work was supported by the Ratchadapiseksompotch Fund, Graduate
   Affairs, Faculty of Medicine, Chulalongkorn University (Grant number
   GA64/21) , a grant from the Graduate School and H.M. the King Bhumibhol
   Adulyadej's 72nd Birthday Anniversary Scholarship Chulalongkorn
   University, and The 100th Anniversary Chulalongkom University Fund for
   Doctoral Scholarship to KJ.
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NR 70
TC 2
Z9 2
U1 1
U2 2
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-3999
EI 1879-1360
J9 J PSYCHOSOM RES
JI J. Psychosomat. Res.
PD DEC
PY 2024
VL 187
AR 111951
DI 10.1016/j.jpsychores.2024.111951
EA OCT 2024
PG 13
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA J3X9H
UT WOS:001336438300001
PM 39413534
DA 2025-06-11
ER

PT J
AU Tang, SY
   Dong, XY
   Ma, YY
   Zhou, H
   He, YH
   Ren, DD
   Li, X
   Cai, YD
   Wang, QK
   Wu, L
AF Tang, Shiying
   Dong, Xiuyu
   Ma, Yueyun
   Zhou, Hui
   He, Yunhai
   Ren, Dandan
   Li, Xiang
   Cai, Yidi
   Wang, Qiukuan
   Wu, Long
TI Highly crystalline cellulose microparticles from dealginated seaweed
   waste ameliorate high fat-sugar diet-induced hyperlipidemia in mice by
   modulating gut microbiota
SO INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
LA English
DT Article
DE Algae; Byproduct; Modification; Metabolite; Intestinal homeostasis;
   Metabolic syndrome
ID METABOLIC SYNDROME; OXIDATIVE STRESS; OBESITY; FIBER; ACIDS; BACTERIA
AB The effects of seaweed cellulose (SC) on high fat-sugar diet (HFSD)-induced glucolipid metabolism disorders in mice and potential mechanisms were investigated. SC was isolated from dealginated residues of giant kelp (Macrocystis pyrifera), with a crystallinity index of 85.51 % and an average particle size of 678.2 nm. Administering SC to C57BL/6 mice at 250 or 500 mg/kg BW/day via intragastric gavage for six weeks apparently inhibited the development of HFSD-induced obesity, dyslipidemia, insulin resistance, oxidative stress and liver damage. Notably, SC intervention partially restored the structure and composition of the gut microbiota altered by the HFSD, substantially lowering the Firmicutes to Bacteroidetes ratio, and greatly increasing the relative abundance of Lactobacillus, Bifidobacterium, Oscillospira, Bacteroides and Akkermansia, which contributed to improved short-chain fatty acid (SCFA) production. Supplementing with a higher dose of SC led to more significant increases in total SCFA (67.57 %), acetate (64.56 %), propionate (73.52 %) and butyrate (66.23 %) concentrations in the rectal contents of HFSD-fed mice. The results indicated that highly crystalline SC microparticles could modulate gut microbiota dysbiosis and ameliorate HFSD-induced obesity and related metabolic syndrome in mice. Furthermore, particle size might have crucial impact on the prebiotic effects of cellulose as insoluble dietary fiber.
C1 [Tang, Shiying; Dong, Xiuyu; Ma, Yueyun; Zhou, Hui; He, Yunhai; Ren, Dandan; Li, Xiang; Cai, Yidi; Wang, Qiukuan; Wu, Long] Dalian Ocean Univ, Coll Food Sci & Engn, Dalian 116023, Peoples R China.
   [Zhou, Hui; He, Yunhai; Ren, Dandan; Li, Xiang; Cai, Yidi; Wang, Qiukuan; Wu, Long] Dalian Ocean Univ, Natl R&D Branch Ctr Seaweed Proc, Ctr Seaweed Proc, Dalian 116023, Peoples R China.
C3 Dalian Ocean University; Dalian Ocean University
RP Wu, L (corresponding author), Dalian Ocean Univ, Coll Food Sci & Engn, Dalian 116023, Peoples R China.
EM zhouhui@dlou.edu.cn; hyh@dlou.edu.cn; rdd@dlou.edu.cn;
   wqk320@dlou.edu.cn; wulong@dlou.edu.cn
RI Yu, Hao/GYD-8698-2022
OI Tang, Shiying/0009-0008-8040-0843
FU National Key Research and Development Program of China [2019YFD0901800];
   National Natural Science Foundation of China [32101861]
FX We acknowledge the financial support of the National Key Research and
   Development Program of China (2019YFD0901800) and National Natural
   Science Foundation of China (32101861) .
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NR 101
TC 6
Z9 6
U1 5
U2 19
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0141-8130
EI 1879-0003
J9 INT J BIOL MACROMOL
JI Int. J. Biol. Macromol.
PD APR
PY 2024
VL 263
AR 130485
DI 10.1016/j.ijbiomac.2024.130485
EA FEB 2024
PN 2
PG 13
WC Biochemistry & Molecular Biology; Chemistry, Applied; Polymer Science
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry; Polymer Science
GA OE6Y8
UT WOS:001205640500001
PM 38423434
DA 2025-06-11
ER

PT J
AU Uchino, K
   Lin, R
   Zaidi, SF
   Kuwabara, H
   Sashin, D
   Bircher, N
   Chang, YF
   Hammer, MD
   Reddy, V
   Jovin, TG
   Vora, N
   Jumaa, M
   Massaro, L
   Billigen, J
   Boada, F
   Yonas, H
   Nemoto, EM
AF Uchino, Ken
   Lin, Ridwan
   Zaidi, Syed F.
   Kuwabara, Hiroto
   Sashin, Donald
   Bircher, Nicholas
   Chang, Yue-Fang
   Hammer, Maxim D.
   Reddy, Vivek
   Jovin, Tudor G.
   Vora, Nirav
   Jumaa, Mouhammad
   Massaro, Lori
   Billigen, Julia
   Boada, Fernando
   Yonas, Howard
   Nemoto, Edwin M.
TI Increased Cerebral Oxygen Metabolism and Ischemic Stress in Subjects
   with Metabolic Syndrome-Associated Risk Factors: Preliminary
   Observations
SO TRANSLATIONAL STROKE RESEARCH
LA English
DT Article
DE Metabolic syndrome; Stroke; Positron emission tomography; Cerebral
   oxygen metabolism; Stroke risk
ID BLOOD-FLOW MEASUREMENTS; HEMODYNAMIC COMPROMISE; INSULIN-RESISTANCE;
   LEPTIN; OBESITY; BRAIN; DISEASE; STROKE; HYPERTENSION; ACTIVATION
AB Hypertension, diabetes, obesity, and dyslipidemia are risk factors that characterize metabolic syndrome (MetS), which increases the risk for stroke by 40%. In a preliminary study, our aim was to evaluate cerebrovascular reactivity and oxygen metabolism in subjects free of vascular disease but with one or more of these risk factors. Volunteers (n=15) 59 +/- 15 (mean +/- SD) years of age clear of cerebrovascular disease by magnetic resonance angiography but with one or more risk factors were studied by quantitative positron emission tomography for measurement of cerebral blood flow, oxygen consumption, oxygen extraction fraction (OEF), and acetazolamide cerebrovascular reactivity. Eight of ten subjects with MetS risk factors had OEF >50%. None of the five without risk factors had OEF >50%. The presence of MetS risk factors was highly correlated with OEF >50% by Fisher's exact test (p<0.007). The increase in OEF was significantly (P<0.001) correlated with cerebral metabolic rate for oxygen. Increased OEF was not associated with compromised acetazolamide cerebrovascular reactivity. Subjects with one or more MetS risk factors are characterized by increased cerebral oxygen consumption and ischemic stress, which may be related to increased risk of cerebrovascular disease and stroke.
C1 [Yonas, Howard; Nemoto, Edwin M.] Univ New Mexico, Dept Neurosurg, Domenici Hall BRaIN Ctr,Room 1131B,1101 Yale Blvd, Albuquerque, NM 87131 USA.
   [Sashin, Donald; Massaro, Lori; Boada, Fernando] Univ Pittsburgh, Med Ctr, Dept Radiol, Pittsburgh, PA USA.
   [Lin, Ridwan; Zaidi, Syed F.; Hammer, Maxim D.; Reddy, Vivek; Jumaa, Mouhammad; Massaro, Lori; Billigen, Julia] Univ Pittsburgh, Med Ctr, Dept Neurol, Pittsburgh, PA USA.
   [Vora, Nirav] St Louis Univ Hosp, Dept Neurol, St Louis, MO USA.
   [Bircher, Nicholas] Univ Pittsburgh, Crit Care Med, Pittsburgh, PA USA.
   [Yonas, Howard] Johns Hopkins Univ, Dept Radiol, Baltimore, MD USA.
   [Uchino, Ken] Cleveland Clin, Cerebrovasc Ctr, Cleveland, OH 44106 USA.
C3 University of New Mexico; Pennsylvania Commonwealth System of Higher
   Education (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth
   System of Higher Education (PCSHE); University of Pittsburgh; Saint
   Louis University; Pennsylvania Commonwealth System of Higher Education
   (PCSHE); University of Pittsburgh; Johns Hopkins University; Cleveland
   Clinic Foundation
RP Nemoto, EM (corresponding author), Univ New Mexico, Dept Neurosurg, Domenici Hall BRaIN Ctr,Room 1131B,1101 Yale Blvd, Albuquerque, NM 87131 USA.
EM enemoto@salud.unm.edu
RI Reddy, Vivek/A-4587-2010; Uchino, Ken/ABC-1611-2021
OI Jumaa, Mouhammad/0000-0002-7165-797X; Uchino, Ken/0000-0001-9468-4172
FU NIH [NS051639, NS061216]
FX No other persons have made substantial contributions to this manuscript.
   This work was supported by NIH grants Nos. NS051639 and NS061216.
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NR 37
TC 6
Z9 9
U1 0
U2 4
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1868-4483
EI 1868-601X
J9 TRANSL STROKE RES
JI Transl. Stroke Res.
PD SEP
PY 2010
VL 1
IS 3
BP 178
EP 183
DI 10.1007/s12975-010-0028-2
PG 6
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA V23ES
UT WOS:000208326700005
PM 22034586
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Alzamendi, A
   Giovambattista, A
   Raschia, A
   Madrid, V
   Gaillard, RC
   Rebolledo, O
   Gagliardino, JJ
   Spinedi, E
AF Alzamendi, Ana
   Giovambattista, Andres
   Raschia, Agustina
   Madrid, Viviana
   Gaillard, Rolf C.
   Rebolledo, Oscar
   Gagliardino, Juan J.
   Spinedi, Eduardo
TI Fructose-rich diet-induced abdominal adipose tissue endocrine
   dysfunction in normal male rats
SO ENDOCRINE
LA English
DT Article
DE Adipokines; Metabolic syndrome; Insulin signalling; Lipids;
   Dexamethasone
ID INSULIN-RESISTANCE; OXIDATIVE STRESS; METABOLIC-SYNDROME; LEPTIN;
   OBESITY; ADIPONECTIN; ADIPOCYTES; COMPLICATIONS; SECRETION; MECHANISM
AB We have currently studied the changes induced by administration of a fructose-rich diet (FRD) to normal rats in the mass and the endocrine function of abdominal (omental) adipose tissue (AAT). Rats were fed ad libitum a standard commercial chow and tap water, either alone (control diet, CD) or containing fructose (10%, w/vol) (FRD). Three weeks after treatment, circulating metabolic markers and leptin release from adipocytes of AAT were measured. Plasma free fatty acids (FFAs), leptin, adiponectin, and plasminogen activator inhibitor-1 (PAI-1) levels were significantly higher in FRD than in CD rats. AAT mass was greater in FRD than in CD rats and their adipocytes were larger, they secreted more leptin and showed impaired insulin sensitivity. While leptin mRNA expression increased in AAT from FRD rats, gene expression of insulin receptor substrate, IRS1 and IRS2 was significantly reduced. Our study demonstrates that administration of a FRD significantly affects insulin sensitivity and several AAT endocrine/metabolic functions. These alterations could be part of a network of interacting abnormalities triggered by FRD-induced oxidative stress at the AAT level. In view of the impaired glucose tolerance observed in FRD rats, these alterations could play a key role in both the development of metabolic syndrome (MS) and beta-cell failure.
C1 [Alzamendi, Ana; Giovambattista, Andres; Spinedi, Eduardo] IMBICE, Neuroendocrine Unit, CONICET, CICPBA, RA-1900 La Plata, Argentina.
   [Raschia, Agustina; Madrid, Viviana; Rebolledo, Oscar; Gagliardino, Juan J.] WHO, CENEXA, UNLP,Collaborating Ctr, CONICET,PAHO, La Plata, Argentina.
   [Gaillard, Rolf C.] Univ Hosp CHUV, Div Endocrinol Diabet & Metab, CH-1011 Lausanne, Switzerland.
C3 Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET);
   World Health Organization; National University of La Plata; Consejo
   Nacional de Investigaciones Cientificas y Tecnicas (CONICET); University
   of Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV)
RP Spinedi, E (corresponding author), IMBICE, Neuroendocrine Unit, CONICET, CICPBA, POB 403, RA-1900 La Plata, Argentina.
EM spinedi@imbice.org.ar
RI Spinedi, Eduardo/F-2455-2016
OI Alzamendi, Ana/0000-0003-4126-1103
FU FONCyT [PICT-2007-01051]; Fondation de Recherche en Endocrinologie; FNSR
   [3200BO-105657/1]; CONICET
FX This study was supported by grants from FONCyT (PICT-2007-01051 to ES),
   Fondation de Recherche en Endocrinologie (2006/2008; to ES), and FNSR
   (3200BO-105657/1; to RCG). ES, JJG, and AG are members of the Research
   Career of CONICET; ORR is a member of the National University Incentives
   Program; AA, AR, and VM are CONICET fellows.The authors gratefully thank
   D. Castrogiovanni for his excellent technical assistance, and A. Di
   Maggio and S. Rogers for manuscript edition and correction,
   respectively.
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NR 33
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U2 21
PU SPRINGER
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PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1355-008X
EI 1559-0100
J9 ENDOCRINE
JI Endocrine
PD APR
PY 2009
VL 35
IS 2
BP 227
EP 232
DI 10.1007/s12020-008-9143-1
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 423TT
UT WOS:000264519300015
PM 19165636
DA 2025-06-11
ER

PT J
AU Scorrano, G
   La Bella, S
   Matricardi, S
   Chiarelli, F
   Giannini, C
AF Scorrano, Giovanna
   La Bella, Saverio
   Matricardi, Sara
   Chiarelli, Francesco
   Giannini, Cosimo
TI Neuroendocrine Effects on the Risk of Metabolic Syndrome in Children
SO METABOLITES
LA English
DT Review
DE metabolic syndrome; obesity; neuroendocrine systems; stress response;
   genetic polymorphisms
ID CORTICOTROPIN-RELEASING HORMONE; POSTTRAUMATIC-STRESS-DISORDER;
   EARLY-ONSET OBESITY; NEUROPEPTIDE-Y; MELANOCORTIN-4 RECEPTOR; PROFOUND
   OBESITY; ADIPOSE-TISSUE; NORMAL-WEIGHT; BODY-WEIGHT; LEPTIN
AB The endocrine and nervous systems reciprocally interact to manage physiological individual functions and homeostasis. The nervous system modulates hormone release through the hypothalamus, the main cerebrally specialized structure of the neuroendocrine system. The hypothalamus is involved in various metabolic processes, administering hormone and neuropeptide release at different levels. This complex activity is affected by the neurons of various cerebral areas, environmental factors, peripheral organs, and mediators through feedback mechanisms. Therefore, neuroendocrine pathways play a key role in metabolic homeostasis control, and their abnormalities are associated with the development of metabolic syndrome (MetS) in children. The impaired functioning of the genes, hormones, and neuropeptides of various neuroendocrine pathways involved in several metabolic processes is related to an increased risk of dyslipidaemia, visceral obesity, insulin resistance, type 2 diabetes mellitus, and hypertension. This review examines the neuroendocrine effects on the risk of MetS in children, identifying and underlying several conditions associated with neuroendocrine pathway disruption. Neuroendocrine systems should be considered in the complex pathophysiology of MetS, and, when genetic or epigenetic mutations in "hot" pathways occur, they could be studied for new potential target therapies in severe and drug-resistant paediatric forms of MetS.
C1 [Scorrano, Giovanna; La Bella, Saverio; Matricardi, Sara; Chiarelli, Francesco; Giannini, Cosimo] Univ G dAnnunzio, Dept Pediat, Via Vestini, I-66100 Chieti, Italy.
C3 G d'Annunzio University of Chieti-Pescara
RP Giannini, C (corresponding author), Univ G dAnnunzio, Dept Pediat, Via Vestini, I-66100 Chieti, Italy.
EM giovanna.scorrano@studenti.unich.it; saverio.labella@studenti.unich.it;
   sara.matricardi@unich.it; chiarelli@unich.it; cosimo.giannini@unich.it
RI La Bella, Saverio/NGR-9557-2025; Giannini, Cosimo/K-9631-2016;
   Matricardi, Sara/C-9552-2018
OI La Bella, Saverio/0000-0002-1244-0789
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Z9 2
U1 1
U2 3
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2218-1989
J9 METABOLITES
JI Metabolites
PD JUL
PY 2023
VL 13
IS 7
AR 810
DI 10.3390/metabo13070810
PG 14
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA N4IB1
UT WOS:001036656300001
PM 37512517
OA gold, Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Yan, S
   Wang, K
   Wang, XY
   Ou, AQ
   Wang, FR
   Wu, LM
   Xue, XF
AF Yan, Sha
   Wang, Kai
   Wang, Xiaoying
   Ou, Aiqun
   Wang, Feiran
   Wu, Liming
   Xue, Xiaofeng
TI Effect of fermented bee pollen on metabolic syndrome in high-fat
   diet-induced mice
SO FOOD SCIENCE AND HUMAN WELLNESS
LA English
DT Article
DE Bee pollen; Fermentation; Gut microbial community; Metabolic syndrome
ID GUT MICROBIOTA; COLLECTED POLLEN; INDUCED OBESITY; IN-VITRO; MODEL;
   EXPRESSION; PRODUCTS
AB Bee pollen has potential in preventing metabolic syndrome (MetS). The present study aimed to investigate the effect of yeast-fermented wall-broken bee pollen (YB) intervention on ICR mice with MetS induced with a high-fat (HF) diet. After YB intervention in mice for 16 weeks, the effect on alleviating MetS was evaluated based on MetS serum parameters, hepatic oxidant status markers and gut microbial populations. The results of animal experiment showed that YB intervention attenuated MetS. Based on multivariate statistical analysis results, YB treatment significantly increased glutathione S-transferase (GST) and catalase (CAT) activities and decreased the malondialdehyde (MDA) level in the liver. Further investigation showed that YB restored the Nrf-2-Keap-1 pathway to alleviate oxidative stress. Additionally, gut microbial community analysis revealed that YB restored the increase in the Firmicutes to Bacteroidetes (F/B) ratio (6.94 for the HF group and 3.74 for HF + YB group) and improved Lactobacillus and Lactococcus abundance induced by the HF diet. Overall, YB improved function and prevented MetS by modulating the gut microbiota and alleviating oxidative stress. (C) 2021 Beijing Academy of Food Sciences. Production and hosting by Elsevier B.V. on behalf of KeAi Communications Co., Ltd.
C1 [Yan, Sha; Wang, Kai; Wang, Xiaoying; Ou, Aiqun; Wang, Feiran; Wu, Liming; Xue, Xiaofeng] Chinese Acad Agr Sci, Inst Apicultural Res, Beijing 100093, Peoples R China.
   [Wu, Liming] Minist Agr, Innovat Res Team Risk Assessment Bee Prod Qual &, Beijing 100093, Peoples R China.
   [Yan, Sha] Shanxi Agr Univ, Coll Food Sci & Engn, Taigu 030801, Peoples R China.
C3 Chinese Academy of Agricultural Sciences; Institute of Apicultural
   Research, CAAS; Ministry of Agriculture & Rural Affairs; Shanxi
   Agricultural University
RP Wu, LM; Xue, XF (corresponding author), Chinese Acad Agr Sci, Inst Apicultural Res, Beijing 100093, Peoples R China.
EM apiswu@126.com; xuebqsitc@126.com
RI Wang, Kai/Q-6434-2018; Wu, liming/AAH-5415-2019
OI Yan, Sha/0000-0002-0652-5380; Wu, Liming/0000-0002-6903-2372
FU National Natural Science Foundation of China [31972628, 31472155];
   Beijing Laboratory for Food Quality and Safety, Beijing Technology and
   Business University;  [NYCYTX-43]
FX We are grateful to Bingyan Wei from Shanxi Medical University for his
   assistance with the animal experiment. This study was supported by the
   National Natural Science Foundation of China (No. 31972628 and
   31472155), a special fund (NYCYTX-43), and the fund of the Beijing
   Laboratory for Food Quality and Safety, Beijing Technology and Business
   University.
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NR 41
TC 17
Z9 18
U1 4
U2 69
PU KEAI PUBLISHING LTD
PI BEIJING
PA 16 DONGHUANGCHENGGEN NORTH ST, BEIJING, DONGHENG DISTRICT 100717,
   PEOPLES R CHINA
EI 2213-4530
J9 FOOD SCI HUM WELL
JI Food Sci. Human Wellness
PD MAY
PY 2021
VL 10
IS 3
BP 345
EP 355
DI 10.1016/j.fshw.2021.02.026
PG 11
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA RP2LU
UT WOS:000641566300009
OA gold
DA 2025-06-11
ER

PT J
AU Li, YQ
   Li, P
   Chu, R
   Tian, WW
   Wang, JX
   Liu, Y
   Gao, J
AF Li, Yu-Qing
   Li, Ping
   Chu, Ran
   Tian, Wei-Wei
   Wang, Jia-Xin
   Liu, Yin
   Gao, Jing
TI Association between the oxidative balance score and mortality in
   patients with metabolic syndrome
SO SCIENTIFIC REPORTS
LA English
DT Article
DE Oxidative balance scores; Metabolic syndrome; Mortality; NHANES;
   Nutrition
ID UNITED-STATES; STRESS; RISK; PREVALENCE
AB Anti-oxidant/Pro-oxidant oxidant imbalance leads to chronic inflammation and insulin resistance can lead to the development of metabolic syndrome (MetS). The oxidative balance score (OBS) is a tool for assessing oxidative stress associated with MetS risk. However, the association between OBS and mortality in patients with MetS remains unclear. This study analyzed 10,647 MetS patients from the 1999-2018 National Health and Nutrition Examination Survey (NHANES). OBS were calculated using a combination of 16 dietary and 4 lifestyle factors. Multivariate Cox proportional hazards regression models, Kaplan-Meier survival analysis, restricted cubic splines (RCS), and subgroup analyses were used to evaluate the potential association between OBS and the risk of all-cause and cardiovascular mortality. Sensitivity analyses confirmed the robustness of the results. This study found that OBS was inversely associated with all-cause and cardiovascular mortality in patients with MetS, a result consistent across most subgroups. Both the Kaplan-Meier curve and RCS analysis supported these findings. Sensitivity analysis was used to verify the robustness of the results. Maintaining an antioxidant-based diet and lifestyle may help reduce the risk of all-cause and cardiovascular mortality in patients with MetS. These findings underscore the significance of incorporating antioxidant-rich dietary patterns and behavioral practices in strategies aimed at preventing and managing MetS.
C1 [Li, Yu-Qing; Li, Ping; Chu, Ran; Tian, Wei-Wei; Wang, Jia-Xin; Gao, Jing] Tianjin Med Univ, Clin Sch Thorac, 22 Qi Xiangtai Rd, Tianjin 300070, Peoples R China.
   [Gao, Jing] Tianjin Chest Hosp, Dept Cardiol, Tianjin, Peoples R China.
   [Liu, Yin; Gao, Jing] Tianjin Chest Hosp, Cardiovasc Inst, 261 Tai Erzhuang Rd, Tianjin 300222, Peoples R China.
   [Gao, Jing] Tianjin Univ, Chest Hosp, 92 Weijin Rd, Tianjin 300072, Peoples R China.
C3 Tianjin Medical University; Tianjin University
RP Gao, J (corresponding author), Tianjin Med Univ, Clin Sch Thorac, 22 Qi Xiangtai Rd, Tianjin 300070, Peoples R China.; Gao, J (corresponding author), Tianjin Chest Hosp, Dept Cardiol, Tianjin, Peoples R China.; Gao, J (corresponding author), Tianjin Chest Hosp, Cardiovasc Inst, 261 Tai Erzhuang Rd, Tianjin 300222, Peoples R China.; Gao, J (corresponding author), Tianjin Univ, Chest Hosp, 92 Weijin Rd, Tianjin 300072, Peoples R China.
EM gaojing2088@163.com
RI Li, Yuqing/KHT-1825-2024
OI Li, Yuqing/0009-0006-6590-2189
FU The Tianjin Health Research Project
FX The data used in this study were from the NHANES. We thank all the staff
   of and participants in the NHANES for their contribution.
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TC 0
Z9 0
U1 2
U2 2
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD MAR 18
PY 2025
VL 15
IS 1
AR 9258
DI 10.1038/s41598-025-90640-w
PG 11
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 0KO7J
UT WOS:001449585600008
PM 40102471
OA gold
DA 2025-06-11
ER

PT J
AU Pasinetti, GM
   Eberstein, JA
AF Pasinetti, Giulio Maria
   Eberstein, Jacqueline A.
TI Metabolic syndrome and the role of dietary lifestyles in Alzheimer's
   disease
SO JOURNAL OF NEUROCHEMISTRY
LA English
DT Review
DE Alzheimer's disease; calorie restriction; diabetes; diet; insulin;
   ketogenic diet; metabolic syndrome; obesity
ID AMYLOID PRECURSOR PROTEIN; GROWTH-FACTOR EXPRESSION; TRANSGENIC MOUSE
   MODEL; LOW CARBOHYDRATE DIETS; GINKGO-BILOBA; A-BETA;
   INSULIN-RESISTANCE; COGNITIVE FUNCTION; OXIDATIVE STRESS; RISK-FACTORS
AB Since Alzheimer's disease (AD) has no cure or preventive treatment, an urgent need exists to find a means of preventing, delaying the onset, or reversing the course of the disease. Clinical and epidemiological evidence suggests that lifestyle factors, especially nutrition, may be crucial in controlling AD. Unhealthy lifestyle choices lead to an increasing incidence of obesity, dyslipidemia and hypertension - components of the metabolic syndrome. These disorders can also be linked to AD. Recent research supports the hypothesis that calorie intake, among other non-genetic factors, can influence the risk of clinical dementia. In animal studies, high calorie intake in the form of saturated fat promoted AD-type amyloidosis, while calorie restriction via reduced carbohydrate intake prevented it. Pending further study, it is prudent to recommend to those at risk for AD - e.g. with a family history or features of metabolic syndrome, such as obesity, insulin insensitivity, etc. - to avoid foods and beverages with added sugars; to eat whole, unrefined foods with natural fats, especially fish, nuts and seeds, olives and olive oil; and to minimize foods that disrupt insulin and blood sugar balance.
C1 [Pasinetti, Giulio Maria] Mt Sinai Sch Med, Ctr Excellence Res Complementary & Alternat Med A, Dept Psychiat, New York, NY 10029 USA.
   [Eberstein, Jacqueline A.] Controlled Carbohydrate Nutr LLC, New York, NY USA.
C3 Icahn School of Medicine at Mount Sinai
RP Pasinetti, GM (corresponding author), Mt Sinai Sch Med, Ctr Excellence Res Complementary & Alternat Med A, Dept Psychiat, 1 Gustave L Levy Pl,Box 1230, New York, NY 10029 USA.
EM giulio.pasinetti@mssm.edu
OI Pasinetti, Giulio/0000-0002-1524-5196
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   2003, HLTH WELLNESS TRENDS
NR 114
TC 121
Z9 140
U1 0
U2 48
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-3042
EI 1471-4159
J9 J NEUROCHEM
JI J. Neurochem.
PD AUG
PY 2008
VL 106
IS 4
BP 1503
EP 1514
DI 10.1111/j.1471-4159.2008.05454.x
PG 12
WC Biochemistry & Molecular Biology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Neurosciences & Neurology
GA 333RQ
UT WOS:000258170400003
PM 18466323
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Wiernsperger, N
   Geloen, A
   Rapin, JR
AF Wiernsperger, Nicolas
   Geloen, Alain
   Rapin, Jean-Robert
TI FRUCTOSE AND CARDIOMETABOLIC DISORDERS: THE CONTROVERSY WILL, AND MUST,
   CONTINUE
SO CLINICS
LA English
DT Review
DE Fructose; Triglycerides; Metabolic syndrome; Uric acid; Hypertension;
   Diet
ID SERUM URIC-ACID; GLUCOSE-SWEETENED BEVERAGES; INDUCED HEPATIC STEATOSIS;
   DIETARY FRUCTOSE; METABOLIC SYNDROME; INSULIN SENSITIVITY;
   LIPID-METABOLISM; CORN SYRUP; KUPFFER CELLS; OXIDATIVE STRESS
AB The present review updates the current knowledge on the question of whether high fructose consumption is harmful or not and details new findings which further pushes this old debate. Due to large differences in its metabolic handling when compared to glucose, fructose was indeed suggested to be beneficial for the diet of diabetic patients. However its growing industrial use as a sweetener, especially in soft drinks, has focused attention on its potential harmfulness, possibly leading to dyslipidemia, obesity, insulin resistance/metabolic syndrome and even diabetes. Many new data have been generated over the last years, confirming the lipogenic effect of fructose as well as risks of vascular dysfunction and hypertension. Fructose exerts various direct effects in the liver, affecting both hepatocytes and Kupffer cells and resulting in non-alcoholic steatotic hepatitis, a well known precursor of the metabolic syndrome. Hepatic metabolic abnormalities underlie indirect peripheral metabolic and vascular disturbances, for which uric acid is possibly the culprit.
   Nevertheless major caveats exist (species, gender, source of fructose, study protocols) which are detailed in this review and presently prevent any firm conclusion. New studies taking into account these confounding factors should be undertaken in order to ascertain whether or not high fructose diet is harmful.
C1 [Wiernsperger, Nicolas; Geloen, Alain] INSA Lyon, INSERM, U870, Villeurbanne, France.
   [Rapin, Jean-Robert] Univ Burgundy, Fac Pharm, Dijon, France.
   [Rapin, Jean-Robert] Assoc Remedes, Orlienas, France.
C3 Institut National des Sciences Appliquees de Lyon - INSA Lyon; Institut
   National de la Sante et de la Recherche Medicale (Inserm); Universite
   Bourgogne Europe
RP Wiernsperger, N (corresponding author), INSA Lyon, INSERM, U870, Villeurbanne, France.
EM nicolas.wiernsperger@free.fr
RI GELOEN, Alain/D-6725-2011
OI GELOEN, Alain/0000-0001-7921-1254
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NR 105
TC 24
Z9 28
U1 0
U2 17
PU HOSPITAL CLINICAS, UNIV SAO PAULO
PI SAO PAULO
PA FAC MEDICINA, UNIV SAO PAULO, SAO PAULO, SP 00000, BRAZIL
SN 1807-5932
EI 1980-5322
J9 CLINICS
JI Clinics
PD JUL
PY 2010
VL 65
IS 7
BP 729
EP 738
DI 10.1590/S1807-59322010000700013
PG 10
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 637HP
UT WOS:000280808400013
PM 20668632
OA Green Published, gold, Green Accepted
DA 2025-06-11
ER

PT J
AU Shahavandi, M
   Shahinfar, H
   Payande, N
   Sheikhhossein, F
   Djafarian, K
   Shab-Bidar, S
AF Shahavandi, Mahshid
   Shahinfar, Hossein
   Payande, Nastaran
   Sheikhhossein, Fatemeh
   Djafarian, Kurosh
   Shab-Bidar, Sakineh
TI The association between dietary antioxidant quality score with metabolic
   syndrome and its components in Iranian adults: A cross-sectional study
SO FOOD SCIENCE & NUTRITION
LA English
DT Article
DE antioxidants; blood pressure; metabolic syndrome; minerals
ID OXIDATIVE STRESS; VALIDITY; VITAMINS; OBESITY; RISK; SUPPLEMENTATION;
   RESISTANCE; PATTERNS; DENSITY; INDEX
AB We aimed to investigate whether adherence to dietary antioxidant quality score (DAQS) is associated with metabolic syndrome (MetS) among the Tehranian population. This cross-sectional study was conducted on 270 apparently healthy adults aged between 18 and 45 years old who lived in Tehran, Iran, between February 2017 and December 2018. Participants were categorized based on tertile cut-off points of DAQs. To examine the association between DAQS and MetS and its components, we used multivariable logistic regression analysis in different models. Adherence to DAQS was associated with a significant increase for intake of vitamin B6 (P-value = 0.02), riboflavin (P-value < 0.001), folate (P-value = 0.03), selenium (P-value = 0.03), vitamin D (P-value < 0.001), and calcium (P-value < 0.001). Adherence to DAQS showed a significant decrease for odds of systolic blood pressure (SBP) (OR: 0.17, 95% CI: 0.04, 0.65, P-value = 0.03). We also found that the overall adherence to DAQS was not significantly related to MetS and its other components. In conclusion, although we observed an improvement in SBP with a greater adherence to dietary antioxidant quality score, there was no association between DAQS and metabolic syndrome and its other components.
C1 [Shahavandi, Mahshid; Shahinfar, Hossein; Payande, Nastaran; Shab-Bidar, Sakineh] Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Community Nutr, 44 Hojjat Dost Alley,Naderi St,Keshavarz Blvd, Tehran, Iran.
   [Shahavandi, Mahshid; Shahinfar, Hossein] Univ Tehran Med Sci, Students Sci Res Ctr SSRC, Tehran, Iran.
   [Sheikhhossein, Fatemeh; Djafarian, Kurosh] Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Clin Nutr, Tehran, Iran.
C3 Tehran University of Medical Sciences; Tehran University of Medical
   Sciences; Tehran University of Medical Sciences
RP Shab-Bidar, S (corresponding author), Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Community Nutr, 44 Hojjat Dost Alley,Naderi St,Keshavarz Blvd, Tehran, Iran.
EM s_shabbidar@tums.ac.ir
RI djafarian, kurosh/D-5563-2018; Shahinfar, Hossein/ABF-9212-2020;
   Shab-Bidar, Sakineh/H-9525-2017
OI Shahinfar, Hossein/0000-0002-4499-4102
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NR 42
TC 11
Z9 11
U1 1
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2048-7177
J9 FOOD SCI NUTR
JI Food Sci. Nutr.
PD FEB
PY 2021
VL 9
IS 2
BP 994
EP 1002
DI 10.1002/fsn3.2067
EA DEC 2020
PG 9
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA QD2RF
UT WOS:000598661300001
PM 33598182
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Li, W
   Chen, Y
   Xu, L
AF Li, W.
   Chen, Y.
   Xu, L.
TI Association of sympathetic nervous system activity with polycystic
   ovarian syndrome
SO CLINICAL AND EXPERIMENTAL OBSTETRICS & GYNECOLOGY
LA English
DT Article
DE Sympathetic nervous system; Polycystic ovary syndrome; PCOS
ID HORMONE-RELEASING HORMONE; INSULIN-RESISTANCE; LOCUS-COERULEUS; COLD
   STRESS; WOMEN; RISK; NOREPINEPHRINE; PREVALENCE; ANXIETY; RATS
AB Polycystic ovary syndrome (PCOS) is a disease with high prevalence which has various clinical manifestations and increased risk of long-term complications, such as dyslipidemia, diabetes, metabolic syndrome, and hormone related tumor. However, the etiology of PCOS is still unclear. Consequently, the effect of symptomatic treatment is not always satisfactory and the prognosis is also unpredictable. Currently, commonly psychological syndromes and imbalance of sympathetic neuroendocrine system have been found in PCOS population, and increasing evidence highlighted the hypothesis that characteristics of PCOS could be partially explained by the instability of the sympathetic nervous system (SNS). Furthermore, surgical intervention of animal trials in order to normalize SNS could improve symptoms of PCOS. This review attempted to clarify the relationship between SNS and PCOS development and then discuss the possible new therapies in PCOS treatment via regulating the SNS.
C1 [Li, W.; Chen, Y.; Xu, L.] Sichuan Univ, Dept Obstet & Gynecol, West China Womens & Childrens Hosp, Chengdu 610064, Sichuan, Peoples R China.
C3 Sichuan University
RP Xu, L (corresponding author), Sichuan Univ, Dept Obstet & Gynecol, West China Womens & Childrens Hosp, Chengdu 610064, Sichuan, Peoples R China.
EM liangzxu@126.com
OI Li, Wenjuan/0000-0002-0517-1162
FU National Natural Science Foundation of China [81270665]; Health
   Department of Sichuan Provincial [090289]
FX The authors would like to thank the National Natural Science Foundation
   of China (Dr. Liangzhi Xu, Principal investigator, Project No.
   81270665), and research projects from Health Department of Sichuan
   Provincial (Dr. Liangzhi Xu, Principal investigator, Project No. 090289)
   for supporting electronic database and literature search.
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NR 68
TC 5
Z9 6
U1 1
U2 11
PU IMR PRESS
PI ROBINSON
PA 112 ROBINSON RD, ROBINSON, SINGAPORE
SN 0390-6663
J9 CLIN EXP OBSTET GYN
JI Clin. Exp. Obstet. Gynecol.
PY 2014
VL 41
IS 5
BP 499
EP 506
PG 8
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA AS0IT
UT WOS:000343961800002
PM 25864247
DA 2025-06-11
ER

PT S
AU Schmidt, MV
   Sterlemann, V
   Müller, MB
AF Schmidt, Mathias V.
   Sterlemann, Vera
   Mueller, Marianne B.
BE Kvetnansky, R
   Aguilera, G
   Goldstein, D
   Jezova, D
   Krizanova, O
   Sabban, EL
   Pacak, K
TI Chronic Stress and Individual Vulnerability
SO Stress, Neurotransmitters, and Hormones: Neuroendocrine and Genetic
   Mechanisms
SE ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
LA English
DT Article; Proceedings Paper
CT 9th Symposium on Catecholamines and Other Neurotransmitters in Stress
CY JUN 16-21, 2007
CL Bethesda, MD
SP Inst Exptl Endocrinol, Ctr Excellence European Commiss, Slovak Acad Sci, Natl Inst Hlth
DE chronic stress; social stress; vulnerability; susceptibility; animal
   model; mouse
ID CHRONIC SOCIAL STRESS; CORTICOTROPIN-RELEASING HORMONE;
   CORONARY-ARTERY-DISEASE; PITUITARY-ADRENAL AXIS; DEPRESSED-PATIENTS;
   MAJOR DEPRESSION; MESSENGER-RNA; MILD STRESS; TREE-SHREWS;
   ARGININE-VASOPRESSIN
AB Over the last decades the burden of disease in Western countries has shifted from comparably easily treated infectious diseases to more complex diseases, such as the metabolic syndrome, cardiovascular disease, and psychiatric disorders. A common characteristic of these illnesses is the interplay of multiple genetic and nongenetic factors, which eventually results in the manifestation of disease symptoms. Large-scale epidemiological studies in humans have resulted in the identification of various environmental and genetic risk factors, which contribute to the onset, duration, and severity of disease. While tremendous progress has been made, it is still impossible to predict which combination of risk factors will result in the manifestation of a specific illness. This lack of knowledge is also frequently reflected in inadequate treatment strategies, which mainly focus on symptom reversal rather than targeting the cause of the diseases. One of the most prominent environmental risk factors described for numerous diseases is chronic exposure to stressful situations. In this paper we address clinical and preclinical evidence of chronic stress as a risk factor for disease and introduce a novel, high-throughput mouse model for chronic social stress. We can show that this model has a high degree of construct, face, and predictive validity in terms of physiological, behavioral, and gene expression changes. We further illustrate how novel animal models of chronic social stress can help to unravel the complex interaction of individual genetic vulnerability and environmental risk factors.
C1 [Schmidt, Mathias V.; Sterlemann, Vera; Mueller, Marianne B.] Max Planck Inst Psychiat, D-80804 Munich, Germany.
C3 Max Planck Society
RP Schmidt, MV (corresponding author), Max Planck Inst Psychiat, RG Mol Stress Physiol,Kraepelinstr 2-10, D-80804 Munich, Germany.
EM mschmidt@mpipsykl.mpg.de
RI Mueller, Marianne/AAL-8911-2021
OI Mueller, Marianne/0000-0002-0269-6131; Schmidt,
   Mathias/0000-0002-3788-2268
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NR 67
TC 82
Z9 95
U1 13
U2 124
PU BLACKWELL PUBLISHING
PI OXFORD
PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXEN, ENGLAND
SN 0077-8923
BN 978-1-57331-692-7
J9 ANN NY ACAD SCI
JI Ann.NY Acad.Sci.
PY 2008
VL 1148
BP 174
EP 183
DI 10.1196/annals.1410.017
PG 10
WC Endocrinology & Metabolism; Multidisciplinary Sciences; Neurosciences;
   Physiology
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Science & Technology - Other Topics;
   Neurosciences & Neurology; Physiology
GA BIS00
UT WOS:000262398300020
PM 19120107
DA 2025-06-11
ER

PT J
AU Segal, SP
   Badran, L
   Rimes, L
AF Segal, Steven P.
   Badran, Leena
   Rimes, Lachlan
TI Accessing acute medical care to protect health: the utility of community
   treatment orders
SO GENERAL PSYCHIATRY
LA English
DT Article
DE mental health; forensic psychiatry; psychiatry; schizophrenia spectrum
   and other psychotic disorders
ID SEVERE MENTAL-ILLNESS; OUTPATIENT COMMITMENT; CARDIOVASCULAR RISK;
   METABOLIC SYNDROME; PHYSICAL ILLNESS; PEOPLE; MORTALITY; SCHIZOPHRENIA;
   PREVALENCE; DISORDERS
AB BackgroundThe conclusion that people with severe mental illness require involuntary care to protect their health (including threats due to physical-non-psychiatric-illness) is challenged by findings indicating that they often lack access to general healthcare and the assertion that they would access such care voluntarily if available and effective. Victoria, Australia's single-payer healthcare system provides accessible medical treatment; therefore, it is an excellent context in which to test these challenges.AimsThis study replicates a previous investigation in considering whether, in Australia's easy-access single-payer healthcare system, patients placed on community treatment orders, specifically involuntary community treatment, are more likely to access acute medical care addressing potentially life-threatening physical illnesses than voluntary patients with and without severe mental illness.MethodsReplicating methods used in 2000-2010, for the years 2010-2017, this study compared the acute medical care access of three new cohorts: 7826 hospitalised patients with severe mental illness who received a post-hospitalisation, community treatment order; 13 896 patients with severe mental illness released from the hospital without a community treatment order and 12 101 outpatients who were never psychiatrically hospitalised (individuals with less morbidity risk who were not considered to have severe mental illness) during periods when they were under versus outside community mental health supervision. Logistic regression was used to determine the influence of community-based community mental health supervision and the type of community mental health supervision (community treatment order vs non-community treatment order) on the likelihood of receiving an initial diagnosis of a life-threatening physical illness requiring acute care.ResultsValidating their shared elevated morbidity risk, 43.7% and 46.7%, respectively, of each hospitalised cohort (community treatment order and non-community treatment order patients) accessed an initial acute-care diagnosis for a life-threatening condition vs 26.3% of outpatients. Outside community mental health supervision, the likelihood that a community treatment order patient would receive a diagnosis of physical illness was 36% lower than non-community treatment order patients-1.30 times that of outpatients. Under community mental health supervision, their likelihood was two times greater than that of non-community treatment order patients and 6.6 times that of outpatients. Each community treatment order episode was associated with a 14.6% increase in the likelihood of a community treatment order patient receiving a diagnosis. The results replicate those found in an independent 2000-2010 cohort comparison.ConclusionsCommunity mental health supervision, notably community treatment order supervision, in two independent investigations over two decades appeared to facilitate access to physical healthcare in acute care settings for patients with severe mental illness who were refusing treatment-a group that has been subject to excess morbidity and mortality.
C1 [Segal, Steven P.; Badran, Leena] Univ Calif Berkeley, Sch Social Welf, Berkeley, CA 94720 USA.
   [Segal, Steven P.] Univ Melbourne, Fac Med Dent & Hlth Sci, Social Work, Melbourne, Vic, Australia.
   [Rimes, Lachlan] Victoria Dept Hlth & Human Serv VDHHS, Melbourne, Vic, Australia.
C3 University of California System; University of California Berkeley;
   University of Melbourne
RP Segal, SP (corresponding author), Univ Calif Berkeley, Sch Social Welf, Berkeley, CA 94720 USA.; Segal, SP (corresponding author), Univ Melbourne, Fac Med Dent & Hlth Sci, Social Work, Melbourne, Vic, Australia.
EM spsegal@berkeley.edu
RI Segal, Steven/AAY-6932-2020; Badran, Leena/HNQ-6792-2023
OI BADRAN, Leena/0000-0002-6585-6008; Rimes, Lachlan/0009-0009-0668-9500
CR Australian Bureau of Statistics, 2011, Technical Paper: Socio-Economic Indexes for Areas (SEIFA)
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NR 30
TC 4
Z9 5
U1 1
U2 3
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2096-5923
EI 2517-729X
J9 GEN PSYCHIAT
JI Gen. Psychiat.
PD DEC
PY 2022
VL 35
IS 6
AR e100858
DI 10.1136/gpsych-2022-100858
PG 10
WC Psychiatry
WE Emerging Sources Citation Index (ESCI)
SC Psychiatry
GA 7F3UN
UT WOS:000901776900001
PM 36654668
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU ElGhareeb, MI
   Khater, MH
   Fakhr, A
   Khedr, HAE
AF ElGhareeb, Mohamed Ibrahim
   Khater, Mohamed Hamed
   Fakhr, Ahmed
   Khedr, Hanaa Abd-Elftah
TI Risk and severity of psoriasis vulgaris in relation to angiotensin II
   type I receptor gene polymorphism and metabolic syndrome
SO CLINICAL COSMETIC AND INVESTIGATIONAL DERMATOLOGY
LA English
DT Article
DE psoriasis; metabolic syndrome; angiotensin receptor; gene polymorphism
ID LIPID PROFILE; OXIDATIVE STRESS; SUSCEPTIBILITY; PREVALENCE; MANAGEMENT
AB Background: Psoriasis vulgaris is a chronic inflammatory and proliferative skin disease, characterized by the formation of itchy, erythematous skin patches or plaques. Patients with psoriasis are at an increased risk of developing metabolic syndrome, including obesity, hypertension, diabetes, and atherosclerosis. Recently, angiotensin II (Ang II) has been reported to be associated with the development of psoriasis. Ang II not only increases the blood pressure but is also a potent proinflammatory modulator and functions through interaction with angiotensin II type 1 receptor (AT1R). Moreover, it is hypothesized that the AT1R gene expression could be correlated with the severity of psoriasis and/or metabolic syndrome.
   Aim: We examined the association of Ang II type 1 receptor (AT1R) A1166C gene polymorphisms and metabolic syndrome with the severity of psoriasis.
   Patients and methods: The present case-control study included 25 patients with psoriasis vulgaris and 25 healthy subjects in Egypt. The psoriasis lesions in the patient group were assessed using the psoriasis area and severity index (PASI) score. The AT1R polymorphism A1166C (rs5186) was studied using restriction fragment length polymorphism (RFLP) and polymerase chain reaction (PCR) amplification of the gene from the whole blood sample in both groups. Serum lipid profile and blood sugar levels were assessed post 12 h and 8 h fasting, respectively, in both groups. The severity of metabolic syndrome was evaluated using the severity score.
   Results: The results of the present study demonstrated that the AT1R A1166C gene polymorphisms increased the risk of developing psoriasis in the Egyptian population. We found that 70% of patients with AC genotype and 100% of patients CC genotype reported a PASI score >20 and were considered to be severe cases with a statistically significant difference as compared with patients with AA genotype (p=0.003). In addition, a high statistically significant difference (p=0.001) existed among AT1R genotypes with respect to the percentage of metabolic syndrome in psoriasis patients. Similarly, a statistically significant difference (p=0.004) among AT1R genotypes with respect to metabolic score was found, with the highest level of score and percentage observed in patients with CC genotype than in patients with AC genotype. The lowest level was present among those with AA genotype.
   Conclusion: Patients with psoriasis expressing the C allele of AT1R1166 are susceptible to developing metabolic syndrome and have higher PASI scores as compared with patients carrying the A allele.
C1 [ElGhareeb, Mohamed Ibrahim; Khater, Mohamed Hamed] Zagazig Univ, Fac Med, Dermatol & Venereol Dept, Zagazig, Egypt.
   [Fakhr, Ahmed] Zagazig Univ, Fac Med, Mol Biol & Immunol Dept, Microbiol, Zagazig, Egypt.
   [Khedr, Hanaa Abd-Elftah] Al Ahrar Hosp, Dermatol Dept, Zagazig, Egypt.
C3 Egyptian Knowledge Bank (EKB); Zagazig University; Egyptian Knowledge
   Bank (EKB); Zagazig University
RP ElGhareeb, MI (corresponding author), Zagazig Univ, Fac Med, Dermatol & Venereol Dept, Zagazig, Egypt.
EM moh_elghareeb@yahoo.com
RI Khater, Mohamed/AAM-6312-2020; Fakhr, Ahmed Elsadek/GYA-0939-2022
OI Fakhr, Ahmed Elsadek/0000-0002-0497-4908; El-Ghareeb El-Ganainy, Mohamed
   Ibrahim/0000-0003-0878-7015
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NR 36
TC 3
Z9 4
U1 0
U2 2
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-7015
J9 CLIN COSMET INV DERM
JI CLIN. COSMET. INVESTIG. DERMATOL.
PY 2019
VL 12
BP 683
EP 690
DI 10.2147/CCID.S212781
PG 8
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA IX7ZX
UT WOS:000485905300001
PM 31571968
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Sobolev, AP
   Ciampa, A
   Ingallina, C
   Mannina, L
   Capitani, D
   Ernesti, I
   Maggi, E
   Businaro, R
   Del Ben, M
   Engel, P
   Giusti, AM
   Donini, LM
   Pinto, A
AF Sobolev, Anatoly Petrovich
   Ciampa, Alessandra
   Ingallina, Cinzia
   Mannina, Luisa
   Capitani, Donatella
   Ernesti, Ilaria
   Maggi, Elisa
   Businaro, Rita
   Del Ben, Maria
   Engel, Petra
   Giusti, Anna Maria
   Donini, Lorenzo M.
   Pinto, Alessandro
TI Blueberry-Based Meals for Obese Patients with Metabolic Syndrome: A
   Multidisciplinary Metabolomic Pilot Study
SO METABOLITES
LA English
DT Article
DE H-1-NMR; urine; cytokines; metabolic syndrome; blueberries
ID NUCLEAR-MAGNETIC-RESONANCE; OXIDATIVE STRESS; GENE-EXPRESSION;
   RISK-FACTORS; INFLAMMATION; ANTHOCYANINS; ADULTS; URINE; SERUM; MOUSE
AB A pilot study was carried out on five obese /overweight patients su ff ering from metabolic syndrome, with the aim to evaluate postprandial e ff ects of high fat /high glycemic load meals enriched by blueberries. Postprandial urine samples were analyzed by 1H-NMR spectroscopy after 2 and 4 h from ingestion to identify potential markers of blueberry intake. Significant decrease of methylamines, acetoacetate, acetone and succinate, known indicators of type 2 diabetes mellitus, were observed after the intake of meals enriched with blueberries. On the other hand, an accumulation of p-hydroxyphenyl-acetic acid and 3-(3'-hydroxyphenyl)-3-hydropropionic acid originating from gut microbial dehydrogenation of proanthocyanidins and procyanidins was detected. Real-time PCR-analysis of mRNAs obtained from mononuclear blood cells showed significant changes in cytokine gene expression levels after meals integrated with blueberries. In particular, the mRNAs expression of interleukin-6 (IL-6) and Transforming Growth Factor-fi (TGF-fi), pro and anti-inflammation cytokines, respectively, significantly decreased and increased after blueberry supplementation, indicating a positive impact of blueberry ingestion in the reduction of risk of inflammation. The combined analysis of the urine metabolome and clinical markers represents a promising approach in monitoring the metabolic impact of blueberries in persons with metabolic syndrome.
C1 [Sobolev, Anatoly Petrovich; Mannina, Luisa; Capitani, Donatella] CNR, Ist Sistemi Biol, Lab Risonanza Magnet Annalaura Segre, Via Salaria Km 29-300, I-00015 Monterotondo, Italy.
   [Ciampa, Alessandra; Ingallina, Cinzia; Mannina, Luisa] Sapienza Univ Roma, Dipartimento Chim & Tecnol Farmaco, Piazzale Aldo Moro 5, I-00185 Rome, Italy.
   [Ernesti, Ilaria; Giusti, Anna Maria; Donini, Lorenzo M.; Pinto, Alessandro] Sapienza Univ Roma, Sez Fisiopatol Med Sci Alimentaz & Endocrinol, Dipartimento Med Sperimentale, Piazzale Aldo Moro 5, I-00185 Rome, Italy.
   [Maggi, Elisa; Businaro, Rita] Sapienza Univ Roma, Dipartimento Sci & Biotecnol Medicochirurg, Corso Repubbl 79, I-04100 Latina, Italy.
   [Del Ben, Maria] Sapienza Univ Roma, Policlin Umberto 1, Dipartimento Med Interna & Specialita Med, Viale Policlin 151, I-00185 Rome, Italy.
   [Engel, Petra] Consiglio Ric Agr & Anal Econ Agr CREA, Ufficio Rapporti Ist & Relaz Int, Via Po 14, I-00198 Rome, Italy.
C3 Consiglio Nazionale delle Ricerche (CNR); Istituto per i Sistemi
   Biologici (ISB-CNR); Sapienza University Rome; Sapienza University Rome;
   Sapienza University Rome; Sapienza University Rome; University Hospital
   Sapienza Rome; Consiglio per la Ricerca in Agricoltura e L'analisi
   Dell'economia Agraria (CREA)
RP Mannina, L (corresponding author), CNR, Ist Sistemi Biol, Lab Risonanza Magnet Annalaura Segre, Via Salaria Km 29-300, I-00015 Monterotondo, Italy.; Ingallina, C; Mannina, L (corresponding author), Sapienza Univ Roma, Dipartimento Chim & Tecnol Farmaco, Piazzale Aldo Moro 5, I-00185 Rome, Italy.
EM cinzia.ingallina@uniroma1.it; luisa.mannina@uniroma1.it
RI Sobolev, Anatoly/AAX-1170-2020; Mannina, Luisa/AGY-1694-2022; Del Ben,
   Maria/AAE-7603-2020; Businaro, Rita/AAG-1866-2021; Ingallina,
   Cinzia/AGX-9596-2022; Donini, Lorenzo/AAS-3873-2020
OI Mannina, Luisa/0000-0001-8659-5890; ciampa,
   alessandra/0000-0001-8734-1315; Ingallina, Cinzia/0000-0003-4817-7318;
   Pinto, Alessandro/0000-0002-4864-2294; SOBOLEV,
   ANATOLY/0000-0001-8709-7666; reverberi, massimo/0000-0003-3671-6783;
   Businaro, Rita/0000-0002-7890-8524; Donini, Lorenzo/0000-0003-4692-4754
FU Italian Ministry of Education, Universities and Research - Dipartimenti
   di Eccellenza [L. 232/2016]; Sapienza University of Rome, Ateneo 2018
   project [RG1181642723114C]; Sapienza University of Rome, Ateneo 2015
   project [C26A15FHES]
FX This work has been realized with funds received from the following
   agencies: Italian Ministry of Education, Universities and Research -
   Dipartimenti di Eccellenza - L. 232/2016; Sapienza University of Rome,
   Ateneo 2018 project (n. prot RG1181642723114C., title: A
   multimethodological pilot study to develop personalized diets including
   functional plant food/beverages and appropriate physical training, for
   young obese adults); and Sapienza University of Rome, Ateneo 2015
   project (n. prot C26A15FHES, title: Polyphenols-driven anti-inflammatory
   activity in chronic degenerative diseases).
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NR 72
TC 19
Z9 20
U1 1
U2 10
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2218-1989
J9 METABOLITES
JI Metabolites
PD JUL
PY 2019
VL 9
IS 7
AR 138
DI 10.3390/metabo9070138
PG 17
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA IR5VL
UT WOS:000481505900023
PM 31295937
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

EF﻿FN Clarivate Analytics Web of Science
VR 1.0
PT J
AU Malagón, MM
   Díaz-Ruiz, A
   Guzmán-Ruiz, R
   Jiménez-Gómez, Y
   Moreno, NR
   García-Navarro, S
   Vazquez-Martínez, R
   Peinado, JR
AF Malagon, Maria M.
   Diaz-Ruiz, Alberto
   Guzman-Ruiz, Rocio
   Jimenez-Gomez, Yolanda
   Moreno, Natalia R.
   Garcia-Navarro, Socorro
   Vazquez-Martinez, Rafael
   Peinado, Juan R.
TI Adipobiology for Novel Therapeutic Approaches in Metabolic Syndrome
SO CURRENT VASCULAR PHARMACOLOGY
LA English
DT Article
DE Adipose tissue; adipocytes; adipokines; adipoproteomics; diet; lipid
   metabolism; metabolic syndrome; obesity
ID DIET-INDUCED OBESITY; POLYUNSATURATED FATTY-ACIDS; INDUCED
   INSULIN-RESISTANCE; NECROSIS-FACTOR-ALPHA; BROWN ADIPOSE-TISSUE;
   ENDOPLASMIC-RETICULUM STRESS; ANTIOBESITY AGENT TUNGSTATE; MATURE 3T3-L1
   ADIPOCYTES; CONJUGATED LINOLEIC-ACID; MITOCHONDRIAL BIOGENESIS
AB Obesity is dramatically increasing virtually worldwide, which has been linked to the rising prevalence of metabolic syndrome. Excess fat accumulation causes severe alterations in adipose tissue function. Actually, adipose tissue is now recognized as a major endocrine and secretory organ that releases a wide variety of signaling molecules (hormones, growth factors, cytokines, chemokines, etc.), the adipokines, which play central roles in the regulation of energy metabolism and homeostasis, immunity and inflammation. In addition, adipose tissue is no longer regarded as a passive lipid storage site but as a highly dynamic energy depot which stores excess energy during periods of positive energy balance and mobilizes it in periods of nutrient deficiency in a tightly regulated manner. Altered lipid release and adipokine production and signaling, as occurs in obesity, are linked to insulin resistance and the associated comorbidities of metabolic syndrome (dyslipidemia, hypertension), which confer an increased risk for the development of type 2 diabetes and cardiovascular disease. Here we summarize current knowledge on adipose tissue and review the contribution of novel techniques and experimental approaches in adipobiology to the identification of novel biomarkers and potential targets for dietary or pharmacological intervention to prevent and treat adipose tissue-associated diseases.
C1 [Malagon, Maria M.; Diaz-Ruiz, Alberto; Guzman-Ruiz, Rocio; Jimenez-Gomez, Yolanda; Moreno, Natalia R.; Garcia-Navarro, Socorro; Vazquez-Martinez, Rafael] Univ Cordoba, Reina Sofia Univ Hosp, Inst Maimonides Invest Biomed Cordoba IMIBIC, Dept Cell Biol Physiol & Immunol, Cordoba 14014, Spain.
   [Malagon, Maria M.; Diaz-Ruiz, Alberto; Guzman-Ruiz, Rocio; Jimenez-Gomez, Yolanda; Garcia-Navarro, Socorro; Vazquez-Martinez, Rafael] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr CIBERobn, Madrid, Spain.
   [Peinado, Juan R.] Univ Castilla La Mancha, Fac Med, Dept Med Sci, E-13071 Ciudad Real, Spain.
C3 Universidad de Cordoba; Instituto de Salud Carlos III; CIBER - Centro de
   Investigacion Biomedica en Red; CIBEROBN; Universidad de Castilla-La
   Mancha
RP Malagón, MM (corresponding author), Univ Cordoba, Dept Cell Biol Physiol & Immunol, Edificio Severo Ochoa,Pl 3,Campus Univ Rabanales, E-14014 Cordoba, Spain.
EM bclmapom@uco.es
RI Vazquez-Martinez, Rafael/G-1243-2016; Guzman-Ruiz, Rocio/V-8462-2019;
   MALAGON, MARIA M/L-5386-2014; Jimenez-Gomez, Yolanda/Y-3742-2018;
   Peinado, Juan Ramon/A-3450-2011
OI Guzman Ruiz, Rocio/0000-0001-8020-4676; MALAGON, MARIA
   M/0000-0002-2419-2727; Jimenez-Gomez, Yolanda/0000-0002-1607-2717;
   Peinado, Juan Ramon/0000-0002-0004-7963; Moreno Castellanos,
   Natalia/0000-0003-2481-3164; Diaz-Ruiz, Alberto/0000-0002-0488-4216
FU Ministerio de Economia y Competitividad/FEDER [BFU2010-17116]; Junta de
   Andalucia/FEDER [CTS-3039, CTS-6606]; CIBER Fisopatologia de la Obesidad
   y Nutricion (CIBERobn; Instituto de Salud Carlos III)
FX This work was supported by Ministerio de Economia y Competitividad/FEDER
   (BFU2010-17116), Junta de Andalucia/FEDER (CTS-3039 and CTS-6606), and
   CIBER Fisopatologia de la Obesidad y Nutricion (CIBERobn; Instituto de
   Salud Carlos III).
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NR 195
TC 14
Z9 15
U1 0
U2 8
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1570-1611
EI 1875-6212
J9 CURR VASC PHARMACOL
JI Current Vascular Pharmacology
PD NOV
PY 2013
VL 11
IS 6
BP 954
EP 967
DI 10.2174/15701611113116660170
PG 14
WC Pharmacology & Pharmacy; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Cardiovascular System & Cardiology
GA AA4IC
UT WOS:000331058300014
PM 24168446
DA 2025-06-11
ER

PT J
AU Holmannova, D
   Borsky, P
   Andrys, C
   Kremlacek, J
   Fiala, Z
   Parova, H
   Rehacek, V
   Esterkova, M
   Poctova, G
   Maresova, T
   Borska, L
AF Holmannova, Drahomira
   Borsky, Pavel
   Andrys, Ctirad
   Kremlacek, Jan
   Fiala, Zdenek
   Parova, Helena
   Rehacek, Vit
   Esterkova, Monika
   Poctova, Gabriela
   Maresova, Tereza
   Borska, Lenka
TI The Influence of Metabolic Syndrome on Potential Aging Biomarkers in
   Participants with Metabolic Syndrome Compared to Healthy Controls
SO BIOMEDICINES
LA English
DT Article
DE aging; metabolic syndrome; NLRP3; klotho; telomerase; AGEs; DNA/RNA
   damage GDF11/15; NAD(+); sirtuin 1; follistatin; vitamin D
ID DNA-DAMAGE; OXIDATIVE STRESS; NLRP3 INFLAMMASOME; TELOMERASE; AGES
AB Background: Biological aging is a physiological process that can be altered by various factors. The presence of a chronic metabolic disease can accelerate aging and increase the risk of further chronic diseases. The aim of the study was to determine whether the presence of metabolic syndrome (MetS) affects levels of markers that are associated with, among other things, aging. Material and Methods: A total of 169 subjects (58 with MetS, and 111 without metabolic syndrome, i.e., non-MetS) participated in the study. Levels of telomerase, GDF11/15, sirtuin 1, follistatin, NLRP3, AGEs, klotho, DNA/RNA damage, NAD(+), vitamin D, and blood lipids were assessed from blood samples using specific enzyme-linked immunosorbent assay (ELISA) kits. Results: Telomerase (p < 0.01), DNA/RNA damage (p < 0.006) and GDF15 (p < 0.02) were higher in MetS group compared to non-MetS group. Only vitamin D levels were higher in the non-MetS group (p < 0.0002). Differences between MetS and non-MetS persons were also detected in groups divided according to age: in under 35-year-olds and those aged 35-50 years. Conclusions: Our results show that people with MetS compared to those without MetS have higher levels of some of the measured markers of biological aging. Thus, the presence of MetS may accelerate biological aging, which may be associated with an increased risk of chronic comorbidities that accompany MetS (cardiovascular, inflammatory, autoimmune, neurodegenerative, metabolic, or cancer diseases) and risk of premature death from all causes.
C1 [Holmannova, Drahomira; Borsky, Pavel; Fiala, Zdenek; Esterkova, Monika; Poctova, Gabriela; Maresova, Tereza; Borska, Lenka] Charles Univ Prague, Inst Prevent Med, Fac Med Hradec Kralove, Hradec Kralove 50003, Czech Republic.
   [Andrys, Ctirad] Univ Hosp Hradec Kralove, Charles Univ, Inst Clin Immunol & Allergol, Hradec Kralove 50003, Czech Republic.
   [Andrys, Ctirad; Parova, Helena] Charles Univ Prague, Fac Med Hradec Kralove, Hradec Kralove 50003, Czech Republic.
   [Kremlacek, Jan] Charles Univ Prague, Inst Med Biophys, Fac Med Hradec Kralove, Hradec Kralove 50003, Czech Republic.
   [Parova, Helena] Univ Hosp Hradec Kralove, Charles Univ, Inst Clin Biochem & Diagnost, Hradec Kralove 50003, Czech Republic.
   [Rehacek, Vit] Univ Hosp Hradec Kralove, Transfus Dept, Hradec Kralove 50003, Czech Republic.
C3 Charles University Prague; University Hospital Hradec Kralove; Charles
   University Prague; University Hospital Hradec Kralove; University
   Hospital Hradec Kralove; Charles University Prague; Charles University
   Prague; University Hospital Hradec Kralove; Charles University Prague;
   University Hospital Hradec Kralove; University Hospital Hradec Kralove
RP Borsky, P (corresponding author), Charles Univ Prague, Inst Prevent Med, Fac Med Hradec Kralove, Hradec Kralove 50003, Czech Republic.
EM borskyp@lfhk.cuni.cz; borka@lfhk.cuni.cz
RI Fiala, Zdeněk/E-5962-2017; Rehacek, Vit/H-4564-2018; Holmannova,
   Drahomira/G-6260-2017; Kremlacek, Jan/A-4313-2008; Borsky,
   Pavel/S-6307-2016; Parova, Helena/S-4857-2016; Borska, Lenka/S-6304-2016
OI Kremlacek, Jan/0000-0001-8641-4287; Holmannova,
   Drahomira/0000-0002-9865-9991; Borsky, Pavel/0000-0001-5253-2808;
   Parova, Helena/0000-0001-5040-4140; Borska, Lenka/0000-0002-8580-1485
FU Charles University, Faculty of Medicine in Hradec Kralove, the Czech
   Republic
FX We would like to acknowledge all the patients participating in the
   study.
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NR 67
TC 2
Z9 2
U1 1
U2 5
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2227-9059
J9 BIOMEDICINES
JI Biomedicines
PD JAN
PY 2024
VL 12
IS 1
AR 242
DI 10.3390/biomedicines12010242
PG 15
WC Biochemistry & Molecular Biology; Medicine, Research & Experimental;
   Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Research & Experimental Medicine;
   Pharmacology & Pharmacy
GA GH9B0
UT WOS:001151884400001
PM 38275413
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Tu, YC
   Liu, YH
   Chen, SC
   Su, HM
AF Tu, Yen-Chieh
   Liu, Yi-Hsueh
   Chen, Szu-Chia
   Su, Ho-Ming
TI Metabolic Syndrome and Its Components Are Associated with New-Onset
   Hyperuricemia in a Large Taiwanese Population Follow-Up Study
SO NUTRIENTS
LA English
DT Article
DE follow-up; Taiwan Biobank; hyperuricemia; metabolic syndrome; metabolic
   syndrome components
ID SERUM URIC-ACID; INSULIN-RESISTANCE; OXIDATIVE STRESS; RISK;
   HYPERTENSION; PREVALENCE; DISEASE; ADULTS; OBESITY; LEVEL
AB The prevalence rate of hyperuricemia remains high in Taiwan, at 21.6% in men and 9.57% in women. Both metabolic syndrome (MetS) and hyperuricemia can cause many complications; however, few studies have evaluated the correlation between MetS and hyperuricemia. Therefore, in this observational cohort study, we explored associations between metabolic syndrome (MetS) and its components and new-onset hyperuricemia. Of 27,033 individuals in the Taiwan Biobank who had complete follow-up data, we excluded those with hyperuricemia at baseline (n = 4871), those with gout at baseline (n = 1043), those with no data on baseline uric acid (n = 18), and those with no data on follow-up uric acid (n = 71). The remaining 21,030 participants (mean age 50.8 +/- 10.3 years) were enrolled. We found a significant association between new-onset hyperuricemia with MetS and the components of MetS (hypertriglyceridemia, abdominal obesity, low high-density lipoprotein cholesterol, hyperglycemia, and high blood pressure). Furthermore, compared to those without any MetS components, those with one MetS component (OR = 1.816), two MetS components (OR = 2.727), three MetS components (OR = 3.208), four MetS components (OR = 4.256), and five MetS components (OR = 5.282) were significantly associated with new-onset hyperuricemia (all p < 0.001). MetS and its five components were associated with new-onset hyperuricemia in the enrolled participants. Further, an increase in the number of MetS components was associated with an increase in the incidence rate of new-onset hyperuricemia.
C1 [Tu, Yen-Chieh; Liu, Yi-Hsueh] Kaohsiung Med Univ, Grad Inst Clin Med, Coll Med, Kaohsiung 807, Taiwan.
   [Tu, Yen-Chieh; Liu, Yi-Hsueh] Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Internal Med, Div Cardiol, Kaohsiung 807, Taiwan.
   [Liu, Yi-Hsueh; Chen, Szu-Chia; Su, Ho-Ming] Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Kaohsiung Municipal Siaogang Hosp, Dept Internal Med, Kaohsiung 812, Taiwan.
   [Chen, Szu-Chia; Su, Ho-Ming] Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Internal Med, Div Nephrol, Kaohsiung 807, Taiwan.
   [Chen, Szu-Chia; Su, Ho-Ming] Kaohsiung Med Univ, Coll Med, Fac Med, Kaohsiung 807, Taiwan.
   [Chen, Szu-Chia] Kaohsiung Med Univ, Res Ctr Precis Environm Med, Kaohsiung 807, Taiwan.
C3 Kaohsiung Medical University; Kaohsiung Medical University; Kaohsiung
   Medical University Hospital; Kaohsiung Medical University; Kaohsiung
   Medical University Hospital; Kaohsiung Municipal Siao-Gang Hospital;
   Kaohsiung Medical University; Kaohsiung Medical University Hospital;
   Kaohsiung Medical University; Kaohsiung Medical University
RP Chen, SC; Su, HM (corresponding author), Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Kaohsiung Municipal Siaogang Hosp, Dept Internal Med, Kaohsiung 812, Taiwan.; Chen, SC; Su, HM (corresponding author), Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Internal Med, Div Nephrol, Kaohsiung 807, Taiwan.; Chen, SC; Su, HM (corresponding author), Kaohsiung Med Univ, Coll Med, Fac Med, Kaohsiung 807, Taiwan.; Chen, SC (corresponding author), Kaohsiung Med Univ, Res Ctr Precis Environm Med, Kaohsiung 807, Taiwan.
EM scarchenone@yahoo.com.tw; cobeshm@seed.net.tw
RI chen, jiayi/IAP-9353-2023; LIU, YI-HSUEH/JRX-0172-2023
OI Liu, Yi-Hsueh/0000-0001-6915-3679
FU Kaohsiung Medical University Research Center grant [KMU-TC111A01,
   KMUTC111IFSP01]; Ministry of Education (MOE) in Taiwan
FX This work was supported, partially, by the Research Center for Precision
   Environmental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
   from The Featured Areas Research Center Program within the framework of
   the Higher Education Sprout Project by the Ministry of Education (MOE)
   in Taiwan and by a Kaohsiung Medical University Research Center grant
   (KMU-TC111A01 and KMUTC111IFSP01).
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NR 54
TC 7
Z9 8
U1 1
U2 14
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD MAR
PY 2023
VL 15
IS 5
AR 1083
DI 10.3390/nu15051083
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 9U9MI
UT WOS:000948027100001
PM 36904083
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Aguilera-Mendez, A
   Hernández-Equihua, MG
   Rueda-Rocha, AC
   Guajardo-López, C
   Nieto-Aguilar, R
   Serrato-Ochoa, D
   Herrera, LFR
   Guzmán-Nateras, JA
AF Aguilera-Mendez, Asdrubal
   Hernandez-Equihua, Maria G.
   Rueda-Rocha, Alfonso C.
   Guajardo-Lopez, Clotilde
   Nieto-Aguilar, Renato
   Serrato-Ochoa, Deyanira
   Ruiz Herrera, Leon F.
   Guzman-Nateras, Jose A.
TI Protective effect of supplementation with biotin against
   high-fructose-induced metabolic syndrome in rats
SO NUTRITION RESEARCH
LA English
DT Article
DE Biotin; Metabolic Syndrome; High-Fructose Diet; Rats
ID FATTY LIVER-DISEASE; CHROMIUM PICOLINATE; ADIPOSE-TISSUE; CORN SYRUP;
   DIET; INSULIN; GLUCOKINASE; EXPRESSION; ACTIVATION; EPIDEMIC
AB Several reports have demonstrated that pharmacological concentrations of biotin reduce hyperglycemia, hypertriglyceridemia, and hypertension. We hypothesized that biotin could exert a protective effect on some illness-associated metabolic syndrome. To test this hypothesis, male Wistar rats were fed a diet containing 30% fructose in drinking water and classified into four groups: C, the control group; B, the group receiving biotin (intraperitoneal injection, 2 mg/kg); F, the group receiving fructose (30% w/v); and FB, the group receiving fructose-biotin. The administration of biotin began after the rats had been on a high-fructose diet for 12 weeks and continued for 4 weeks. Our results showed that food and fluid intake were diminished in the F and FB groups. However, the final body weights were similar between the groups. A significant increase in hepatic triglyceride and cholesterol content, plasma cholesterol, triglyceiides, transaminases, low-density lipoprotein cholesterol (LDL-c), systolic blood pressure, and vasocontraction, as well as a decrease in high density lipoprotein cholesterol (HDL-c) were observed in the F group. Glucose tolerance and insulin tolerance were also impaired in the F group. The administration of biotin ameliorated all these changes. Hepatic oxidative stress as well as macrovesicular fatty changes in hepatocytes caused by a high-fructose diet were also improved by biotin. Our findings demonstrate that biotin has a protective role against metabolic syndrome by improving insulin resistance associated with normal hepatic and serum levels of triglyceride and cholesterol, blood pressure, and the prevention of steatosis and hepatic oxidative damage. Therefore, biotin could be used as a therapeutic strategy in the pharmacological treatment of metabolic syndrome. (C) 2018 Elsevier Inc. All rights reserved.
C1 [Aguilera-Mendez, Asdrubal; Hernandez-Equihua, Maria G.; Rueda-Rocha, Alfonso C.; Ruiz Herrera, Leon F.] Univ Michoacana, Inst Biol Chem Res, Morelia 58040, Michoacan, Mexico.
   [Guajardo-Lopez, Clotilde] Gen & Oncol Histopathol Diag ROBBINS, Morelia 58060, Michoacan, Mexico.
   [Nieto-Aguilar, Renato; Serrato-Ochoa, Deyanira] Univ Michoacana, Sch Dent, Univ Ctr Postgrad Studies & Res, Morelia 58337, Michoacan, Mexico.
   [Guzman-Nateras, Jose A.] Ctr Med & Res & Sci Appl Sport, Morelia 58010, Michoacan, Mexico.
C3 Universidad Michoacana de San Nicolas de Hidalgo; Universidad Michoacana
   de San Nicolas de Hidalgo
RP Aguilera-Mendez, A (corresponding author), Av J Mujica, Morelia 58040, Michoacan, Mexico.
EM amendez@umich.mx
RI Aguilera-Méndez, Asdrubal/AAG-4797-2020; NIETO-AGUILAR,
   RENATO/L-9909-2018
OI NIETO-AGUILAR, RENATO/0000-0002-4009-1942; Aguilera Mendez,
   Asdrubal/0000-0003-0326-2068
FU CONACYT [CVU 687564, CVU 733965];  [C.I.C.-UMSNH 3.36];  [CECTI CB 16]
FX This research was funded by grant C.I.C.-UMSNH 3.36, and CECTI CB 16.
   Mana Guadalupe Hernandez Equihua and Alfonso Characu Rueda Rocha are
   recipients of the CONACYT scholarship number CVU 687564 and CVU 733965,
   respectively. We acknowledge that the authors have no financial interest
   or other contractual agreements that might cause conflicts of interest
   or be perceived as causing conflicts of interest in any company or
   organization sponsoring the research. The authors would like to thank
   Luis Fernando Guzman Nateras for the English language review. Conceived
   and designed the experiments: AAM. Performed the experiments: MHE, ARR,
   CGL. Analyzed the data: AAM, RNA, DSO. Contributed
   reagents/materials/analysis tools: AAM, MHE, ARR. Wrote the paper. AAM,
   JGN.
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NR 57
TC 29
Z9 30
U1 0
U2 21
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0271-5317
J9 NUTR RES
JI Nutr. Res.
PD SEP
PY 2018
VL 57
BP 86
EP 96
DI 10.1016/j.nutres.2018.06.007
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA GS3PH
UT WOS:000443531500009
PM 30122199
DA 2025-06-11
ER

PT J
AU Tavallaie, MS
   Voshtani, R
   Deng, XX
   Qiao, YX
   Jiang, FQ
   Collman, JP
   Fu, L
AF Tavallaie, Mojdeh S.
   Voshtani, Ramouna
   Deng, Xinxian
   Qiao, Yixue
   Jiang, Faqin
   Collman, James P.
   Fu, Lei
TI Moderation of mitochondrial respiration mitigates metabolic syndrome of
   aging
SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF
   AMERICA
LA English
DT Article
DE aging; mitochondria; mitogenesis; metabolic syndrome; cytochrome c
   oxidase
ID ADIPOSE-TISSUE MACROPHAGES; ENERGY-METABOLISM; OBESITY; DYNAMICS; AMPK;
   THERMOGENESIS; ACCUMULATION; RESTRICTION; RESVERATROL; BIOGENESIS
AB Deregulation of mitochondrial dynamics leads to the accumulation of oxidative stress and unhealthy mitochondria; consequently, this accumulation contributes to premature aging and alterations in mitochondria linked to metabolic complications. We postulate that restrained mitochondrial ATP synthesis might alleviate age-associated disorders and extend healthspan in mammals. Herein, we prepared a previously discovered mitochondrial complex IV moderate inhibitor in drinking water and orally administered to standard-diet-fed, wild-type C57BL/6J mice every day for up to 16 mo. No manifestation of any apparent toxicity or deleterious effect on studied mouse models was observed. The impacts of an added inhibitor on a variety of mitochondrial functions were analyzed, such as respiratory activity, mitochondrial bioenergetics, and biogenesis, and a few age-associated comorbidities, including reactive oxygen species (ROS) production, glucose abnormalities, and obesity in mice. It was found that mitochondrial quality, dynamics, and oxidative metabolism were greatly improved, resulting in lean mice with a specific reduction in visceral fat plus superb energy and glucose homeostasis during their aging period compared to the control group. These results strongly suggest that a mild interference in ATP synthesis through moderation of mitochondrial activity could effectively up-regulate mitogenesis, reduce ROS production, and preserve mitochondrial integrity, thereby impeding the onset of metabolic syndrome. We conclude that this inhibitory intervention in mitochondrial respiration rectified the age-related physiological breakdown in mice by protecting mitochondrial function and markedly mitigated certain undesired primary outcomes of metabolic syndrome, such as obesity and type 2 diabetes. This intervention warrants further research on the treatment of metabolic syndrome of aging in humans.
C1 [Tavallaie, Mojdeh S.; Deng, Xinxian; Qiao, Yixue; Jiang, Faqin; Fu, Lei] Shanghai Jiao Tong Univ, Sch Pharm, Shanghai Key Lab Mol Engn Chiral Drugs, Shanghai 200240, Peoples R China.
   [Voshtani, Ramouna] Shanghai Jiao Tong Univ, Sch Life Sci, Dept Genet & Immunol, Shanghai 200240, Peoples R China.
   [Collman, James P.] Stanford Univ, Dept Chem, Stanford, CA 94305 USA.
C3 Shanghai Jiao Tong University; Shanghai Jiao Tong University; Stanford
   University
RP Fu, L (corresponding author), Shanghai Jiao Tong Univ, Sch Pharm, Shanghai Key Lab Mol Engn Chiral Drugs, Shanghai 200240, Peoples R China.; Collman, JP (corresponding author), Stanford Univ, Dept Chem, Stanford, CA 94305 USA.
EM jpc@stanford.edu; leifu@sjtu.edu.cn
OI , Xinxian/0000-0003-4064-8883; Tavallaie, Mojdeh
   Sonia/0000-0001-7166-2499; Voshtani, Ramouna/0009-0007-6270-2066; Fu,
   Lei/0000-0002-0802-6446; Qiao, Yixue/0000-0001-9643-7327
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NR 70
TC 50
Z9 52
U1 0
U2 29
PU NATL ACAD SCIENCES
PI WASHINGTON
PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA
SN 0027-8424
J9 P NATL ACAD SCI USA
JI Proc. Natl. Acad. Sci. U. S. A.
PD MAY 5
PY 2020
VL 117
IS 18
BP 9840
EP 9850
DI 10.1073/pnas.1917948117
PG 11
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA LK7UR
UT WOS:000531067600035
PM 32303655
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Ohbu-Murayama, K
   Adachi, H
   Hirai, Y
   Enomoto, M
   Fukami, A
   Obuchi, A
   Yoshimura, A
   Nakamura, S
   Nohara, Y
   Nakao, E
   Umeki, Y
   Fukumoto, Y
AF Ohbu-Murayama, Kyoko
   Adachi, Hisashi
   Hirai, Yuji
   Enomoto, Mika
   Fukami, Ako
   Obuchi, Aya
   Yoshimura, Ayako
   Nakamura, Sachiko
   Nohara, Yume
   Nakao, Erika
   Umeki, Yoko
   Fukumoto, Yoshihiro
TI Ezetimibe combined with standard diet and exercise therapy improves
   insulin resistance and atherosclerotic markers in patients with
   metabolic syndrome
SO Journal of Diabetes Investigation
LA English
DT Article
DE Ezetimibe; Insulin resistance; Metabolic syndrome
ID LIPID-ALTERING EFFICACY; CORONARY-HEART-DISEASE; JAPANESE PATIENTS;
   CHOLESTEROL ABSORPTION; GLUCOSE-METABOLISM; GENERAL-POPULATION;
   OXIDATIVE STRESS; HIGH-RISK; HYPERCHOLESTEROLEMIA; EZETIMIBE/SIMVASTATIN
AB Aims/IntroductionEzetimibe lowers serum lipid levels by inhibiting intestinal absorption of dietary and biliary cholesterol. However, the effect of ezetimibe on insulin resistance remains unclear. The aim of the present study was to examine this issue in patients with metabolic syndrome in local-dwelling Japanese, who were not being treated with lipid-lowering drugs.
   Materials and MethodsIn 2009, 1,943 participants received a health examination in the Tanushimaru Study, a Japanese cohort of the Seven Countries Study, of whom 490 participants had metabolic syndrome. Among them, 61 participants (41 men and 20 women) were examined in the present study. They were treated with 10mg of ezetimibe once a day for 24weeks, combined with standard diet and exercise therapy.
   ResultsBodyweight (P<0.001), body mass index (P<0.001), systolic blood pressure (P=0.003), diastolic blood pressure (P<0.001), triglycerides (P=0.002), non-high-density lipoprotein cholesterol (P=0.001), low-density lipoprotein cholesterol (P<0.001) and homeostasis model assessment of insulin resistance (P=0.011) significantly decreased after the observational period. There were no statistically significant differences in the effects of ezetimibe between men and women. Univariate analysis showed that the reduction of homeostasis model assessment of insulin resistance was not associated with the improvement of other metabolic components.
   ConclusionsEzetimibe combined with standard diet and exercise therapy improves not only bodyweight and atherogenic lipid profiles, but also insulin resistance, blood pressure and anthropometric factors in metabolic syndrome in local-dwelling Japanese. Interestingly, the improvement of insulin resistance had no correlation with other metabolic components.
C1 [Ohbu-Murayama, Kyoko; Hirai, Yuji; Enomoto, Mika; Fukami, Ako; Obuchi, Aya; Yoshimura, Ayako; Nakamura, Sachiko; Nohara, Yume; Nakao, Erika; Umeki, Yoko; Fukumoto, Yoshihiro] Kurume Univ, Sch Med, Dept Internal Med, Div Cardiovasc Med, Kurume, Fukuoka 830, Japan.
   [Adachi, Hisashi] Kurume Univ, Sch Med, Dept Community Med, Kurume, Fukuoka 830, Japan.
C3 Kurume University; Kurume University
RP Adachi, H (corresponding author), Kurume Univ, Sch Med, Dept Community Med, Kurume, Fukuoka 830, Japan.
EM hadac@med.kurume-u.ac.jp
FU Kimura Memorial Heart Foundation (Fukuoka, Japan); Bayer Pharmaceutical
   Co., Ltd.
FX We are grateful to the members of the Japan Medical Association of
   Ukiha, the elected officials and residents of Tanushimaru, and the team
   of cooperating physicians for their help in carrying out the health
   examinations. This study was supported in part by the Kimura Memorial
   Heart Foundation (Fukuoka, Japan) and by Bayer Pharmaceutical Co., Ltd.
   We also certify that there are no financial or other relationships that
   could lead to a conflict of interest.
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NR 37
TC 15
Z9 15
U1 0
U2 5
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2040-1116
EI 2040-1124
J9 J DIABETES INVEST
JI J. Diabetes Investig.
PD MAY
PY 2015
VL 6
IS 3
BP 325
EP 333
DI 10.1111/jdi.12298
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA CG7QI
UT WOS:000353498800013
PM 25969718
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Meerarani, P
   Badimon, JJ
   Zias, E
   Fuster, V
   Moreno, PR
AF Meerarani, P.
   Badimon, J. J.
   Zias, E.
   Fuster, V.
   Moreno, P. R.
TI Metabolic syndrome and diabetic atherothrombosis: Implications in
   vascular complications
SO CURRENT MOLECULAR MEDICINE
LA English
DT Review
DE metabolic syndrome; obesity; type 2 diabetes mellitus; atherosclerosis;
   peroxisome proliferator activator receptor; endothelial dysfunction;
   reactive oxygen species
ID HIGH-DENSITY-LIPOPROTEIN; CORONARY-ARTERY CALCIFICATION; ESTER TRANSFER
   PROTEIN; INSULIN-RESISTANCE; VASA VASORUM; ENDOTHELIAL FUNCTION;
   PPAR-GAMMA; INTIMAL NEOVASCULARIZATION; ATHEROSCLEROTIC LESIONS;
   CARDIOVASCULAR-DISEASE
AB Metabolic syndrome is characterized by the clustering of a number of metabolic abnormalities in the presence of underlying insulin resistance with a strong association with diabetes and cardiovascular disease morbidity and mortality. The disorder is defined in different ways, but the pathophysiology is attributable to insulin resistance. An increased release of free fatty acids (FFAs) from adipocytes block insulin signal transduction pathway, induce endothelial dysfunction due to increased reactive oxygen species (ROS) generation and oxidative stress. Dyslipidemia, associated with high levels of triglycerides and low concentrations of high density lipoproteins (HDLs), contributes to a proinflammatory state. Inflammation, the key pathogenic component of atherosclerosis, promotes thrombosis, a process that underlies acute coronary event and stroke. Tissue factor, a potent trigger of the coagulation cascade, is increased in diabetes with poor glycemic control. Therapeutic lifestyle changes (weight loss and physical activity) along with pharmacological interventions are recommended to prevent the complications of metabolic syndrome. In addition to statins, metformin, blood pressure lowering medications, interventions to increase HDLs are other important approaches to decrease the risk of cardiovascular disease. Furthermore, the peroxisome proliferator activated receptor (PPAR) alpha and gamma agonists are potent anti-inflammatory and anti-atherogenic agents that could both improve insulin sensitivity and the long-term cardiovascular risk.
   In this review we focus on the molecular and pathophysiological basis of metabolic syndrome, which augments diabetes (insulin resistance) and the contribution of neovascularization in the plaque progression in diabetes, leading to rupture and coronary thrombosis.
C1 CUNY Mt Sinai Sch Med, Zena & Michael Wiener Cardiovasc Inst, New York, NY 10029 USA.
C3 City University of New York (CUNY) System; Icahn School of Medicine at
   Mount Sinai
RP Moreno, PR (corresponding author), CUNY Mt Sinai Sch Med, Zena & Michael Wiener Cardiovasc Inst, POB 1030,1 Gustave L Levy Pl, New York, NY 10029 USA.
EM Pedro.Moreno@msnyuhealth.org
RI Fuster, Valentin/H-4319-2015
OI Fuster, Valentin/0000-0002-9043-9986
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NR 143
TC 47
Z9 51
U1 0
U2 9
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1566-5240
EI 1875-5666
J9 CURR MOL MED
JI Curr. Mol. Med.
PD AUG
PY 2006
VL 6
IS 5
BP 501
EP 514
DI 10.2174/156652406778018680
PG 14
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 069XN
UT WOS:000239482700006
PM 16918371
DA 2025-06-11
ER

PT J
AU Farag, HAM
   Hosseinzadeh-Attar, MJ
   Muhammad, BA
   Esmaillzadeh, A
   El Bilbeisi, AH
AF Farag, Halgord Ali M.
   Hosseinzadeh-Attar, Mohammad Javad
   Muhammad, Belal A.
   Esmaillzadeh, Ahmad
   El Bilbeisi, Abdel Hamid
TI Comparative effects of vitamin D and vitamin C supplementations with and
   without endurance physical activity on metabolic syndrome patients: a
   randomized controlled trial
SO DIABETOLOGY & METABOLIC SYNDROME
LA English
DT Article
DE Endurance physical activity; IDF; Metabolic syndrome; Vitamin C; Vitamin
   D
ID BODY-MASS INDEX; CARDIOVASCULAR-DISEASE; WAIST CIRCUMFERENCE; OXIDATIVE
   STRESS; MUSCLE STRENGTH; OLDER-ADULTS; MORTALITY; WEIGHT; RISK;
   METAANALYSIS
AB ObjectiveVitamin D and C levels have inverse relation with the metabolic syndrome components and they are used as antioxidant supplements during enduring metabolic activities. In the present study, we hypothesized that the intake of vitamin D and/or C with endurance physical activity might reduce the risk of metabolic syndrome.MethodsA randomized control study recruited 180 participants of both genders, aged between 30 and 50years. The participants were assigned into six groups receiving different doses of vitamin D or vitamin C with or without physical activities. Data were collected over a period of 3months, and the results were analyzed using SPSS version 20.ResultsVariations in the effect of the supplements on various body variables including: Fasting plasma glucose, total cholesterol, low-density lipoprotein cholesterol and blood pressure, showed that vitamin D has more influence compared to vitamin C. However, vitamin D and C supplements do not have any effect on weight when consumers are undergoing endurance physical exercise. But vitamin C consumer group has more effect in waist circumference, triglyceride, and high-density lipoprotein, as compared to vitamin D consumer group.ConclusionWe conclude that, consumption of vitamin D or vitamin C supplements may improves the life of metabolic syndrome patients. However, the combination of physical activities and vitamin supplements maximize the effect, and this combination should be recommended.Trial registration WHO-ICTRP IRCT20161110030823N2. Registered 01 February 2018. http://apps.who.int/trialsearch/Trial2.aspx?TrialID=IRCT20161110030823N2
C1 [Farag, Halgord Ali M.; Hosseinzadeh-Attar, Mohammad Javad; El Bilbeisi, Abdel Hamid] Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Clin Nutr, Int Campus TUMS IC, Tehran, Iran.
   [Farag, Halgord Ali M.; Muhammad, Belal A.] Sulaimani Polytech Univ, Halabja Tech Inst, Kurdistan, Iraq.
   [Esmaillzadeh, Ahmad] Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Community Nutr, Tehran, Iran.
C3 Tehran University of Medical Sciences; Sulaimani Polytechnic University;
   Tehran University of Medical Sciences
RP El Bilbeisi, AH (corresponding author), Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Clin Nutr, Int Campus TUMS IC, Tehran, Iran.
EM abed_az@hotmail.com
RI Bilbeisi, Abdel/Q-9356-2019; Esmaillzadeh, Ahmad/N-5704-2014;
   Hosseinzadeh-Attar, Mohammad Javad/E-9358-2018
OI Hosseinzadeh-Attar, Mohammad Javad/0000-0002-5787-4089
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NR 54
TC 12
Z9 13
U1 1
U2 6
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1758-5996
J9 DIABETOL METAB SYNDR
JI Diabetol. Metab. Syndr.
PD NOV 8
PY 2018
VL 10
AR 80
DI 10.1186/s13098-018-0384-8
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA HA0GJ
UT WOS:000449885600001
PM 30455745
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Roca-Rodríguez, MD
   López-Tinoco, C
   Fernández-Deudero, A
   Murri, M
   García-Palacios, MV
   García-Valero, MD
   Tinahones, FJ
   Aguilar-Diosdado, M
AF del Mar Roca-Rodriguez, Maria
   Lopez-Tinoco, Cristina
   Fernandez-Deudero, Alvaro
   Murri, Mora
   Victoria Garcia-Palacios, Maria
   del Amor Garcia-Valero, Maria
   Jose Tinahones, Francisco
   Aguilar-Diosdado, Manuel
TI Unfavorable cytokine and adhesion molecule profiles during and after
   pregnancy, in women with gestational diabetes mellitus
SO ENDOCRINOLOGIA DIABETES Y NUTRICION
LA English
DT Article
DE Metabolic syndrome; Adipokines; Endothelial dysfunction; Gestational
   diabetes mellitus; Postpartum
ID INSULIN-RESISTANCE; E-SELECTIN; METABOLIC SYNDROME; OXIDATIVE STRESS;
   OBESE WOMEN; TNF-ALPHA; RISK; POSTPARTUM; ADIPOKINES; COMPLICATIONS
AB Background: Gestational diabetes mellitus is a significant risk factor for metabolic syndrome and cardiovascular disease.
   Aims: To assess the relationships between components of the metabolic syndrome and cytokine and adhesion molecule levels in women with GDM during pregnancy and after delivery.
   Patients and methods: A prospective case-control study on a sample of 126 pregnant women (63 with and 63 without gestational diabetes mellitus). In an intra-subject analysis, 41 women with history of gestational diabetes mellitus and 21 controls were re-assessed in the postpartum period. Clinical data and levels of cytokines and adhesion molecules were recorded during weeks 24-29 of pregnancy and 12 months after delivery.
   Results: In the postpartum period, there were significantly higher levels of tumor necrosis factor alpha in both cases and controls, and of adiponectin in controls. Cases showed higher leptin levels, with no significant differences during and after pregnancy. No significant differences were seen in adhesion molecules and interleukin-6 between cases and controls during pregnancy and in the postpartum period, but levels of both were higher in cases. During pregnancy and after delivery, adiponectin decreased in cases and increased in controls. Significant positive correlations were seen between adiponectin and fasting blood glucose levels and vascular cell adhesion molecule-1, and also between leptin and tumor necrosis factor alpha levels.
   Conclusions: The results suggest that increased inflammation and transient hyperglycemia during pregnancy would represent a latent form of metabolic syndrome, with an increased risk for type 2 diabetes mellitus and future cardiovascular disease. (C) 2017 SEEN. Published by Elsevier Espana, S.L.U. All rights reserved.
C1 [del Mar Roca-Rodriguez, Maria; Lopez-Tinoco, Cristina; del Amor Garcia-Valero, Maria; Aguilar-Diosdado, Manuel] Puerta Mar Hosp, Dept Endocrinol, Cadiz, Spain.
   [Fernandez-Deudero, Alvaro] Puerta Mar Hosp, Invest Unit, Cadiz, Spain.
   [Murri, Mora] Ramon & Cajal Hosp, Invest Unit, Madrid, Spain.
   [Victoria Garcia-Palacios, Maria] Puerta Mar Hosp, Dept Prevent Med & Publ Hlth, Cadiz, Spain.
   [Jose Tinahones, Francisco] Reg & Clin Hosp, Dept Endocrinol, Malaga, Spain.
C3 Hospital Universitario Ramon y Cajal
RP Aguilar-Diosdado, M (corresponding author), Puerta Mar Hosp, Dept Endocrinol, Cadiz, Spain.
EM maroca80@gmail.com; manuel.aguilar.sspa@juntadeandalucia.es
RI Tinahones, Francisco/AAB-2882-2020; Lopez-Tinoco, Cristina/K-5420-2019;
   Aguilar Diosdado, Manuel/A-2549-2009
OI Tinahones, Francisco J/0000-0001-6871-4403; Garcia Palacios, Maria
   Victoria/0000-0002-2003-0966; Murri, Mora/0000-0002-6482-192X; Fernandez
   Deudero, Alvaro/0009-0007-3292-3933; Aguilar Diosdado,
   Manuel/0000-0001-9657-5949
FU Andalusia Department of Health [CTS-368: PI-0525-2012, PI-405/06,
   PI-11/00676]
FX Editorial assistance was by Dr. Peter R Turner. This study was financed,
   in part, by grants from the Andalusia Department of Health (CTS-368:
   PI-0525-2012; PI-405/06; PI-11/00676).
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NR 30
TC 14
Z9 14
U1 0
U2 6
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2530-0180
J9 ENDOCRINOL DIAB NUTR
JI Endocrinol. Diabetes Nutr.
PD JAN
PY 2017
VL 64
IS 1
BP 18
EP 25
DI 10.1016/j.endinu.2016.10.003
PG 8
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA EY2HZ
UT WOS:000403790500004
PM 28440766
DA 2025-06-11
ER

PT J
AU Santiago, JVA
   Jayachitra, J
   Shenbagam, M
   Nalini, N
AF Santiago, Jesudoss Victor Antony
   Jayachitra, Jayaraman
   Shenbagam, Madhavan
   Nalini, Namasivayam
TI Dietary d-limonene alleviates insulin resistance and oxidative
   stress-induced liver injury in high-fat diet and L-NAME-treated rats
SO EUROPEAN JOURNAL OF NUTRITION
LA English
DT Article
DE Nonalcoholic fatty liver disease; Metabolic syndrome; High-fat diet;
   L-NAME; d-limonene
ID GLUTATHIONE S-TRANSFERASES; REDUCTASE; INHIBITION; MODEL; ACID;
   PURIFICATION; METABOLISM; DISEASE; COMBINATION; MICROSOMES
AB Background Nonalcoholic fatty liver disease (NAFLD) is one of the most common etiologies of chronic liver disease worldwide. The pathogenesis of metabolic syndrome associated with NAFLD is still under debate.
   Aim of the scope This study has investigated the hepatic biochemical and histological changes and also insulin resistance in metabolic syndrome associated with NAFLD.
   Methods Young male Wistar rats fed a high-fat diet (HFD 42.2% beef tallow) together with N-omega-nitro-L-arginine methyl ester (L-NAME; 80 mg/L in drinking water) for 8 weeks and subsequently with 2% d-limonene for the final 4 weeks.
   Results HFD-fed rats treated with L-NAME showed increased systolic blood pressure, heart rate, fasting blood glucose, plasma insulin, hepatic marker enzymes, hepatic lipids, circulatory lipid peroxidation by-products, and hepatic phase I enzyme activities with decreased circulatory nonenzymic antioxidant concentrations and hepatic phase II enzyme activities. Dietary supplementation with d-limonene reversed the HFD and L-NAME-induced changes and restored pathological alteration of liver and pancreas.
   Conclusions These data provide new insights into the therapeutic approach of d-limonene against the development of the metabolic syndrome associated with NAFLD.
C1 [Santiago, Jesudoss Victor Antony; Jayachitra, Jayaraman; Shenbagam, Madhavan; Nalini, Namasivayam] Annamalai Univ, Fac Sci, Dept Biochem & Biotechnol, Annamalainagar 608002, Tamil Nadu, India.
C3 Annamalai University
RP Nalini, N (corresponding author), Annamalai Univ, Fac Sci, Dept Biochem & Biotechnol, Annamalainagar 608002, Tamil Nadu, India.
EM nalininam@yahoo.com
RI M, Shenbagam/X-5572-2019
OI M, Shenbagam/0000-0001-9833-4073
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NR 64
TC 71
Z9 76
U1 5
U2 39
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1436-6207
EI 1436-6215
J9 EUR J NUTR
JI Eur. J. Nutr.
PD FEB
PY 2012
VL 51
IS 1
BP 57
EP 68
DI 10.1007/s00394-011-0182-7
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 895WB
UT WOS:000300526300006
PM 21445622
DA 2025-06-11
ER

PT J
AU Pedersen, ALW
   Lindekilde, CR
   Andersen, K
   Hjorth, P
   Gildberg, FA
AF Pedersen, Anne Louise Winkler
   Lindekilde, Camilla Rosendal
   Andersen, Kjeld
   Hjorth, Peter
   Gildberg, Frederik Alkier
TI Health behaviours of forensic mental health service users, in relation
   to smoking, alcohol consumption, dietary behaviours and physical
   activity-A mixed methods systematic review
SO JOURNAL OF PSYCHIATRIC AND MENTAL HEALTH NURSING
LA English
DT Review
DE crime and mental health; forensic; health promotion; prevention;
   systematic literature reviews
ID METABOLIC SYNDROME; RISK-FACTORS; MORTALITY; PEOPLE; INDIVIDUALS;
   PREVALENCE; FITNESS; PROGRAM; BURDEN
AB Accessible summaryWhat is known on the subject
   People with mental disorders have increased risk of dying from diabetes and cardiovascular diseases compared to the general population. Diabetes and cardiovascular diseases are preventable by improved lifestyle regarding smoking, alcohol consumption, physical activity and dietary behaviours. Forensic mental health service users are treated for longer periods of time compared to non-forensic mental health service users, giving the opportunity to affect the lifestyle for a substantial period of time. What the paper adds to existing knowledge
   This review gathers existing research on forensic mental health service users' lifestyle regarding smoking, alcohol consumption, physical activity, and dietary behaviours and factors influencing it. The lifestyle was found to be unfavourable with many patients being smokers, having problematic alcohol consumption, being physically inactive and eating a diet of poor nutritional value and rich in calories. Therefore, it seems likely that an unfavourable lifestyle is one reason for the excess mortality from diabetes and cardiovascular diseases. Smoking cessation and improving dietary habits was perceived difficult, but nicotine replacement and practical advice was suggested to support a change. What are the implications for practice
   The treatment period gives an opportunity to improve the lifestyle of forensic mental health service users to prevent diabetes and cardiovascular diseases in this high-risk group. We recommend a holistic approach, when planning the prevention activities, since activities that are perceived fun are more likely to succeed. Introduction People with mental disorders have increased risk of dying from diabetes and cardiovascular diseases, both of which can be prevented by lifestyle. Aim To review existing research, in order to investigate the characteristics of, and factors that influence forensic mental health service users' (FMU) health behaviours. Method We searched PubMed, CINAHL, PsycInfo and Scopus for primary research on FMU's health behaviours regarding smoking, alcohol consumption, physical activity and dietary behaviours, and factors that influence them. Results We found 13 eligible studies. The findings consistently indicated the presence of unfavourable health behaviours in FMU: Smoking, problematic alcohol consumption, physical inactivity and a high-calorie diet of poor nutritional value. Changing smoking and dietary habits was perceived as difficult, but nicotine replacement and practical advice were suggested to support change. Discussion The existing research on FMU's health behaviours is sparse. In particular, there is a lack of research on factors that influence health behaviours. From our findings, it seems likely that FMU's unfavourable health behaviours contribute to their increased risk of dying from diabetes and cardiovascular diseases. Implications for practice FMU's health behaviours should be improved to prevent diabetes and cardiovascular diseases in this high-risk group.
C1 [Pedersen, Anne Louise Winkler; Lindekilde, Camilla Rosendal; Gildberg, Frederik Alkier] Reg Southern Denmark, Dept Psychiat Middelfart, Res Unit Forens Mental Hlth, Middelfart, Denmark.
   [Pedersen, Anne Louise Winkler; Hjorth, Peter; Gildberg, Frederik Alkier] Univ Southern Denmark, Fac Hlth Sci, Inst Reg Hlth Res, Ctr Psychiat Nursing & Hlth Res, Odense, Denmark.
   [Pedersen, Anne Louise Winkler] Odense Univ Hosp, OPEN, Odense Patient Data Explorat Network, Odense, Denmark.
   [Andersen, Kjeld] Reg Southern Denmark, Univ Clin, Mental Hlth Serv, Dept Mental Hlth Odense, Middelfart, Denmark.
   [Hjorth, Peter] Reg Southern Denmark, Dept Psychiat, Vejle, Denmark.
C3 University of Southern Denmark; University of Southern Denmark; Odense
   University Hospital
RP Pedersen, ALW (corresponding author), Reg Southern Denmark, Dept Psychiat Middelfart, Res Unit Forens Mental Hlth, Middelfart, Denmark.
EM anne.louise.pedersen@rsyd.dk
RI ; Andersen, Kjeld/K-2169-2014; Gildberg, Frederik/K-6577-2013
OI Pedersen, Anne Louise Winkler/0000-0002-5257-9224; Andersen,
   Kjeld/0000-0003-0456-5634; Lindekilde, Camilla/0000-0001-6165-7792;
   Gildberg, Frederik/0000-0001-9075-6108; Hjorth,
   Peter/0000-0001-7548-5848
FU Psychiatry Research Fund in the Region of Southern Denmark; University
   of Southern Denmark
FX The Psychiatry Research Fund in the Region of Southern Denmark;
   University of Southern Denmark: Scholarship
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NR 43
TC 17
Z9 17
U1 1
U2 18
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1351-0126
EI 1365-2850
J9 J PSYCHIATR MENT HLT
JI J. Psychiatr. Ment. Health Nurs.
PD JUN
PY 2021
VL 28
IS 3
BP 444
EP 461
DI 10.1111/jpm.12688
EA OCT 2020
PG 18
WC Nursing; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Psychiatry
GA SA0GF
UT WOS:000576591300001
PM 32916759
OA Green Published
DA 2025-06-11
ER

PT J
AU Anderson, G
   Maes, M
AF Anderson, George
   Maes, Michael
TI Melatonin: an overlooked factor in schizophrenia and in the inhibition
   of anti-psychotic side effects
SO METABOLIC BRAIN DISEASE
LA English
DT Review
DE Melatonin; Schizophrenia; Anti-psychotics; Metabolic; Inflammation;
   Vitamin D
ID VITAMIN-D; KYNURENINE PATHWAY; TARDIVE-DYSKINESIA; CYTOKINE ALTERATIONS;
   SEASONAL-VARIATION; MAJOR DEPRESSION; MEDICATION-NAIVE; BIPOLAR
   DISORDER; CIRCADIAN-RHYTHM; INNATE IMMUNITY
AB This paper reviews melatonin as an overlooked factor in the developmental etiology and maintenance of schizophrenia; the neuroimmune and oxidative pathophysiology of schizophrenia; specific symptoms in schizophrenia, including sleep disturbance; circadian rhythms; and side effects of antipsychotics, including tardive dyskinesia and metabolic syndrome. Electronic databases, i.e. PUBMED, Scopus and Google Scholar were used as sources for this review using keywords: schizophrenia, psychosis, tardive dyskinesia, antipsychotics, metabolic syndrome, drug side effects and melatonin. Articles were selected on the basis of relevance to the etiology, course and treatment of schizophrenia. Melatonin levels and melatonin circadian rhythm are significantly decreased in schizophrenic patients. The adjunctive use of melatonin in schizophrenia may augment the efficacy of antipsychotics through its anti-inflammatory and antioxidative effects. Further, melatonin would be expected to improve sleep disorders in schizophrenia and side effects of anti-psychotics, such as tardive dyskinesia, metaboilic syndrome and hypertension. It is proposed that melatonin also impacts on the tryptophan catabolic pathway via its effect on stress response and cortisol secretion, thereby impacting on cortex associated cognition, amygdala associated affect and striatal motivational processing. The secretion of melatonin is decreased in schizophrenia, contributing to its etiology, pathophysiology and management. Melatonin is likely to have impacts on the metabolic side effects of anti-psychotics that contribute to subsequent decreases in life-expectancy.
C1 [Anderson, George] CRC, Glasgow G11 7QT, Lanark, Scotland.
   [Maes, Michael] Piyavate Hosp, Bangkok, Thailand.
RP Anderson, G (corresponding author), CRC, Rm 30,57 Laurel St, Glasgow G11 7QT, Lanark, Scotland.
EM anderson.george@rocketmail.com
RI Maes, Michael/B-8546-2011; Anderson, George/AEO-3626-2022
OI Anderson, George/0000-0001-7243-0817; Maes, Michael/0000-0002-2012-871X
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NR 85
TC 64
Z9 68
U1 1
U2 49
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0885-7490
EI 1573-7365
J9 METAB BRAIN DIS
JI Metab. Brain Dis.
PD JUN
PY 2012
VL 27
IS 2
BP 113
EP 119
DI 10.1007/s11011-012-9307-9
PG 7
WC Endocrinology & Metabolism; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology
GA 940BO
UT WOS:000303865200002
PM 22527998
DA 2025-06-11
ER

PT J
AU Ali, A
   Yazaki, Y
   Njike, VY
   Ma, YY
   Katz, DL
AF Ali, Ather
   Yazaki, Yuka
   Njike, Valentine Y.
   Ma, Yingying
   Katz, David L.
TI Effect of fruit and vegetable concentrates on endothelial function in
   metabolic syndrome: A randomized controlled trial
SO NUTRITION JOURNAL
LA English
DT Article
DE phytonutrients; dietary supplements; cardiovascular; antioxidant;
   randomized; fruit; vegetable
ID CORONARY-HEART-DISEASE; ANTIOXIDANT VITAMIN SUPPLEMENTS; BETA-CAROTENE;
   MYOCARDIAL-INFARCTION; ACUTE HYPERGLYCEMIA; OXIDATIVE STRESS;
   BRACHIAL-ARTERY; E CONSUMPTION; RISK; DYSFUNCTION
AB Background and Objective: Dehydrated fruit and vegetable concentrates provide an accessible form of phytonutrient supplementation that may offer cardioprotective effects. This study assessed the effects of two blends of encapsulated juice powder concentrates (with and without added berry powders) on endothelial function in persons with metabolic syndrome, a risk factor for type 2 diabetes and cardiovascular disease.
   Methods: Randomized, double blind, placebo controlled crossover clinical trial with three treatment arms. 64 adults with metabolic syndrome were enrolled and received 8-week sequences of each blend of the concentrates and placebo. The primary outcome measure was change in endothelial function (assessed as flow-mediated dilatation of the brachial artery) 2 hr after consuming a 75 g glucose load, after 8-weeks of daily consumption (sustained) or 2 hr after consumption of a single dose (acute). Secondary outcome measures included plasma glucose, serum insulin, serum lipids, and body weight.
   Results: No significant between-group differences in endothelial function with daily treatment for 8 weeks were seen. No other significant treatment effects were discerned in glucose, insulin, lipids, and weight.
   Conclusion: Encapsulated fruit and vegetable juice powder concentrates did not alter insulin or glucose measures in this sample of adults with metabolic syndrome.
C1 [Ali, Ather; Yazaki, Yuka; Njike, Valentine Y.; Ma, Yingying; Katz, David L.] Yale Univ, Sch Med, Griffin Hosp, Prevent Res Ctr, Derby, CT 06418 USA.
C3 Yale University
RP Katz, DL (corresponding author), Yale Univ, Sch Med, Griffin Hosp, Prevent Res Ctr, 130 Div St,2nd Floor, Derby, CT 06418 USA.
EM david.katz@yale.edu
OI Njike, Valentine/0000-0001-5468-3175; Katz, David L./0000-0001-6845-6192
FU NSA (Collierville, TN)
FX This trial was supported by funding from NSA (Collierville, TN). The
   sponsor provided intervention and placebo capsules. The sponsor had no
   influence in the design, conduct, interpretation, and publication of the
   results.
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NR 58
TC 19
Z9 20
U1 0
U2 9
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1475-2891
J9 NUTR J
JI Nutr. J.
PD JUN 29
PY 2011
VL 10
AR 72
DI 10.1186/1475-2891-10-72
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 791YT
UT WOS:000292706800001
PM 21714890
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Castanon, N
   Luheshi, G
   Layé, S
AF Castanon, Nathalie
   Luheshi, Giamal
   Laye, Sophie
TI Role of neuroinflammation in the emotional and cognitive alterations
   displayed by animal models of obesity
SO FRONTIERS IN NEUROSCIENCE
LA English
DT Review
DE obesity; anxiety; depression; memory impairments; inflammation;
   neuroinflammation; indoleamine 2-3-dioxygenase; GTP-cyclohydrolase 1
ID HIGH-FAT DIET; DEPRESSIVE-LIKE BEHAVIOR; BRAIN INDOLEAMINE
   2,3-DIOXYGENASE; BODY-MASS INDEX; CHRONIC IMMUNE ACTIVATION; BACILLE
   CALMETTE-GUERIN; LOW-GRADE INFLAMMATION; ANXIETY-LIKE BEHAVIORS;
   METABOLIC SYNDROME; BARIATRIC SURGERY
AB Obesity is associated with a high prevalence of mood disorders and cognitive dysfunctions in addition to being a significant risk factor for important health complications such as cardiovascular diseases and type 2 diabetes. Identifying the pathophysiological mechanisms underlying these health issues is a major public health challenge. Based on recent findings, from studies conducted on animal models of obesity, it has been proposed that inflammatory processes may participate in both the peripheral and brain disorders associated with the obesity condition including the development of emotional and cognitive alterations. This is supported by the fact that obesity is characterized by peripheral low-grade inflammation, originating from increased adipose tissue mass and/or dysbiosis (changes in gut microbiota environment), both of which contribute to increased susceptibility to immune-mediated diseases. In this review, we provide converging evidence showing that obesity is associated with exacerbated neuroinflammation leading to dysfunction in vulnerable brain regions associated with mood regulation, learning, and memory such as the hippocampus. These findings give new insights to the pathophysiological mechanisms contributing to the development of brain disorders in the context of obesity and provide valuable data for introducing new therapeutic strategies for the treatment of neuropsychiatric complications often reported in obese patients.
C1 [Castanon, Nathalie; Laye, Sophie] Univ Bordeaux, INRA, UMR 1286, Nutr & Integrat Neurobiol, F-33076 Bordeaux, France.
   [Luheshi, Giamal] McGill Univ, Dept Psychiat, Douglas Mental Hlth Univ Inst, Montreal, PQ, Canada.
C3 Universite de Bordeaux; INRAE; Institut National de la Sante et de la
   Recherche Medicale (Inserm); McGill University
RP Castanon, N (corresponding author), Univ Bordeaux, INRA, UMR 1286, Lab Nutr & Integrat Neurobiol, 146 Rue Leo Saignat, F-33076 Bordeaux, France.
EM nathalie.castanon@bordeaux.inra.fr
RI Laye, Sophie/AAX-2501-2020
OI Laye, Sophie/0000-0002-3843-1012; Castanon, Nathalie/0000-0002-0079-0562
FU Institut National de la Recherche Agronomique (INRA); Region Aquitaine
   [2013 13 03 001]
FX This publication was supported by the Institut National de la Recherche
   Agronomique (INRA) and by the Region Aquitaine (Grant number: 2013 13 03
   001; NC).
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NR 188
TC 135
Z9 144
U1 0
U2 29
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1662-453X
J9 FRONT NEUROSCI-SWITZ
JI Front. Neurosci.
PD JUL 3
PY 2015
VL 9
AR 229
DI 10.3389/fnins.2015.00229
PG 14
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA CS5KQ
UT WOS:000362117300001
PM 26190966
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Al-Hakeim, HK
   Al-Rubaye, HT
   Jubran, AS
   Almulla, AF
   Moustafa, SR
   Maes, M
AF Al-Hakeim, Hussein Kadhem
   Al-Rubaye, Haneen Tahseen
   Jubran, Abdulsahib S.
   Almulla, Abbas F.
   Moustafa, Shatha Rouf
   Maes, Michael
TI Increased insulin resistance due to long COVID is associated with
   depressive symptoms and partly predicted by the inflammatory response
   during acute infection
SO BRAZILIAN JOURNAL OF PSYCHIATRY
LA English
DT Article
DE Inflammation; oxidative and nitrosative stress; major depression; mood
   disorders; biomarkers
ID ENZYME GENE-EXPRESSION; METABOLIC SYNDROME; OXIDATIVE STRESS;
   SKELETAL-MUSCLE; METFORMIN; WOMEN; MODE
AB Objective: Some months after the remission of acute COVID-19, some individuals show depressive symptoms, which are predicted by increased peak body temperature (PBT) and decreased blood oxygen saturation (SpO2). The present study aimed to examine data on whether long COVID is associated with increased insulin resistance (IR) in association with neuroimmune and oxidative (NIO) processes during the acute infectious and long COVID phases. Methods: This case-control, retrospective cohort study used the Homeostasis Model Assessment 2 (HOMA2) calculator & to compute b-cell function (HOMA2%B) and insulin sensitivity (HOMA2%S) and resistance (HOMA2-IR) and administered the Beck Depression Inventory (BDI) and Hamilton Depression Rating Scale (HAMD) to 86 patients with long COVID and 39 controls. Results: Long COVID (3-4 months after the acute infection) is accompanied by increased HOMA2-IR, fasting blood glucose (FBG), and insulin levels; 33.7% of the patients vs. 0% of the controls had HOMA2-IR values 4 1.8, suggesting IR. Increased IR was predicted by PBT during acute infection and associated with depressive symptoms above and beyond the effects of NIO pathways (nucleotidebinding domain, leucine-rich repeat, and pyrin domain-containing protein 3 [NLRP3] inflammasome, myeloperoxidase [MPO], protein oxidation). There were no significant associations between increased IR and the activated NIO pathways during long COVID. Conclusion: Long COVID is associated with new-onset IR, which may contribute to onset of depressive symptoms due to long COVID by enhancing overall neurotoxicity.
C1 [Al-Hakeim, Hussein Kadhem] Univ Kufa, Coll Sci, Dept Chem, Kufa, Iraq.
   [Al-Rubaye, Haneen Tahseen] Imam Jaafar Al Sadiq Univ, Coll Med Lab Tech, Najaf, Iraq.
   [Jubran, Abdulsahib S.] Univ Alkafeel, Coll Dent, Najaf, Iraq.
   [Almulla, Abbas F.] Islamic Univ, Coll Med Technol, Med Lab Technol Dept, Najaf, Iraq.
   [Moustafa, Shatha Rouf] Hawler Med Univ, Coll Pharm, Clin Anal Dept, Erbil, Iraq.
   [Maes, Michael] Chulalongkorn Univ, Fac Med, Dept Psychiat, Bangkok, Thailand.
   [Maes, Michael] Med Univ Plovdiv, Dept Psychiat, Plovdiv, Bulgaria.
   [Maes, Michael] Deakin Univ, Inst Mental & Phys Hlth & Clin Translat, Sch Med, Barwon Hlth, Geelong, Australia.
   [Maes, Michael] King Chulalongkorn Mem Hosp, Dept Psychiat, Fac Med, 1873 Rama IV Rd, Bangkok 10330, Thailand.
C3 University of Kufa; Imam Jaa'far al-Sadiq University; Islamic University
   College; Hawler Medical University; Chulalongkorn University; Medical
   University Plovdiv; Deakin University; Chulalongkorn University
RP Maes, M (corresponding author), King Chulalongkorn Mem Hosp, Dept Psychiat, Fac Med, 1873 Rama IV Rd, Bangkok 10330, Thailand.
EM dr.michaelmaes@hotmail.com
RI Maes, Michael/B-8546-2011; Jubran, Abdulsahib/AEI-8372-2022; Almulla,
   Abbas F./ABG-7926-2020; Al-Hakeim, Hussein/G-1151-2011; Almulla, Abbas
   F./G-7975-2018; Al-Rubaye, Haneen/HSF-0588-2023
OI Almulla, Abbas F./0000-0002-7667-6731; Jubran, Dr.
   Abdulsahib/0000-0001-9448-6707; Al-Rubaye, Haneen/0009-0001-2448-8974;
   Maes, Michael/0000-0002-2012-871X
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NR 84
TC 19
Z9 19
U1 0
U2 4
PU ASSOC BRASILEIRA PSIQUIATRIA
PI SAO PAULO
PA SUBSCRIPTION DEPARTMENT, RUA PEDRO DE TOLEDO, 967 - CASA 01, SAO PAULO,
   SP 04039-032  A, BRAZIL
SN 1516-4446
EI 1809-452X
J9 BRAZ J PSYCHIAT
JI Braz. J. Psychiat.
PD MAY-JUN
PY 2023
VL 45
IS 3
BP 205
EP 215
DI 10.47626/1516-4446-2022-3002
PG 11
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA L8LQ9
UT WOS:001025728800001
PM 36917827
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Panchal, SK
   Bliss, E
   Brown, L
AF Panchal, Sunil K.
   Bliss, Edward
   Brown, Lindsay
TI Capsaicin in Metabolic Syndrome
SO NUTRIENTS
LA English
DT Review
DE capsaicin; metabolic syndrome; transient receptor potential vanilloid
   channel 1; TRPV1; obesity; insulin resistance; diabetes; non-alcoholic
   fatty liver disease
ID DIET-INDUCED OBESITY; POTENTIAL VANILLOID 1; FATTY LIVER-DISEASE;
   SENSORY NERVE DESENSITIZATION; INDUCED INSULIN-RESISTANCE; OXIDATIVE
   STRESS; GLUCOSE-TOLERANCE; SENSITIVE NERVES; GUT MICROBIOTA;
   PLASMA-GLUCOSE
AB Capsaicin, the major active constituent of chilli, is an agonist on transient receptor potential vanilloid channel 1 (TRPV1). TRPV1 is present on many metabolically active tissues, making it a potentially relevant target for metabolic interventions. Insulin resistance and obesity, being the major components of metabolic syndrome, increase the risk for the development of cardiovascular disease, type 2 diabetes, and non-alcoholic fatty liver disease. In vitro and pre-clinical studies have established the effectiveness of low-dose dietary capsaicin in attenuating metabolic disorders. These responses of capsaicin are mediated through activation of TRPV1, which can then modulate processes such as browning of adipocytes, and activation of metabolic modulators including AMP-activated protein kinase (AMPK), peroxisome proliferator-activated receptor (PPAR), uncoupling protein 1 (UCP1), and glucagon-like peptide 1 (GLP-1). Modulation of these pathways by capsaicin can increase fat oxidation, improve insulin sensitivity, decrease body fat, and improve heart and liver function. Identifying suitable ways of administering capsaicin at an effective dose would warrant its clinical use through the activation of TRPV1. This review highlights the mechanistic options to improve metabolic syndrome with capsaicin.
C1 [Panchal, Sunil K.; Bliss, Edward; Brown, Lindsay] Univ Southern Queensland, Funct Foods Res Grp, Toowoomba, Qld 4350, Australia.
   [Bliss, Edward; Brown, Lindsay] Univ Southern Queensland, Sch Hlth & Wellbeing, Toowoomba, Qld 4350, Australia.
C3 University of Southern Queensland; University of Southern Queensland
RP Brown, L (corresponding author), Univ Southern Queensland, Funct Foods Res Grp, Toowoomba, Qld 4350, Australia.; Brown, L (corresponding author), Univ Southern Queensland, Sch Hlth & Wellbeing, Toowoomba, Qld 4350, Australia.
EM Sunil.Panchal@usq.edu.au; Edward.Bliss@usq.edu.au;
   Lindsay.Brown@usq.edu.au
RI Bliss, Edward/HZI-0958-2023
OI Panchal, Sunil K/0000-0001-5464-3376; Brown, Lindsay/0000-0001-7837-991X
FU University of Southern Queensland Research & Innovation division;
   Advance Queensland Early Career Research Fellowship
FX The authors' (S.K.P. and L.B.) research program is supported by
   University of Southern Queensland Research & Innovation division. S.K.P.
   is supported through an Advance Queensland Early Career Research
   Fellowship while E.B. is supported through Research Training Program. No
   external funding was received for this work.
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NR 177
TC 114
Z9 120
U1 3
U2 56
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 2072-6643
J9 NUTRIENTS
JI Nutrients
PD MAY
PY 2018
VL 10
IS 5
AR 630
DI 10.3390/nu10050630
PG 21
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA GJ3LI
UT WOS:000435196000104
PM 29772784
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Lim, JS
   Kwon, HM
AF Lim, Jae-Sung
   Kwon, Hyung-Min
TI Risk of "silent stroke" in patients older than 60 years: risk assessment
   and clinical perspectives
SO CLINICAL INTERVENTIONS IN AGING
LA English
DT Review
DE silent brain infarction; elderly; risk factors; treatment
ID NITRIC-OXIDE SYNTHASE; WHITE-MATTER LESIONS; SMALL-VESSEL DISEASE;
   C-REACTIVE PROTEIN; BRAIN INFARCTS; CEREBRAL INFARCTION; METABOLIC
   SYNDROME; BLOOD-PRESSURE; CEREBROVASCULAR-DISEASE; LACUNAR INFARCTION
AB With the increasing size of the elderly population and evolving imaging technology, silent brain infarction (SBI) has garnered attention from both the public and the physicians. Over 20% of the elderly exhibit SBI, and the prevalence of SBI increases steadily with age, ie, 30%-40% in those older than 70 years. Well-known cardiovascular risk factors such as hypertension has been identified as a risk factor of SBI (odds ratio [OR] = 3.47) Besides this, blood pressure (BP) reactivity to mental stress, morning BP surges, and orthostatic BP changes have been demonstrated to contribute to the presence of SBI. Further, a metabolic syndrome not only as a whole syndrome (OR = 2.18) but also as individual components could have an influence on SBI. Increased C-reactive protein and interleukin-6, coronary artery disease, body mass index, and alcohol consumption have also been associated with SBI. The ORs and - possible mechanisms have been discussed in this article. Overt stroke, dementia, depression, and aspiration pneumonia were all associated with SBI. (overt stroke: hazard ratio [HR] = 1.9, 95% confidence interval [CI]: 1.2-2.8; dementia: HR = 2.26, 95% CI: 1.09-4.70). We also looked into their close relationship with SBI in this review.
C1 [Kwon, Hyung-Min] Seoul Natl Univ, Coll Med, Dept Neurol, Boramae Hosp, Seoul 156707, South Korea.
   [Lim, Jae-Sung] Armed Forces Seoul Hosp, Dept Neurol, Seoul, South Korea.
C3 Seoul National University (SNU); Seoul National University Hospital
RP Kwon, HM (corresponding author), Seoul Natl Univ, Coll Med, Dept Neurol, Boramae Hosp, 39 Boramae Gil, Seoul 156707, South Korea.
EM hmkwon@snu.ac.kr
RI Kwon, Hyung-Min/D-6356-2012; Lim, Jae-Sung/D-5555-2012
OI Lim, Jae-Sung/0000-0001-6157-2908; Kwon, Hyung-Min/0000-0002-6101-7127
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NR 79
TC 31
Z9 40
U1 0
U2 18
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
EI 1178-1998
J9 CLIN INTERV AGING
JI Clin. Interv. Aging
PY 2010
VL 5
BP 239
EP 251
DI 10.2147/CIA.S7382
PG 13
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA V21XA
UT WOS:000208239100026
PM 20852671
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Im, J
   Park, H
   Park, K
AF Im, Jihyun
   Park, Hyoungsu
   Park, Kyong
TI Higher Intake of Total Dietary Essential Amino Acids Is Associated with
   a Lower Prevalence of Metabolic Syndrome among Korean Adults
SO NUTRIENTS
LA English
DT Article
DE essential amino acid; metabolic syndrome; dietary intake; nutrition
   requirement; Korea
ID POPULATION; GENE; MORTALITY; LEUCINE; PROTEIN; STRESS; SENSOR; CELLS;
   MTOR; RISK
AB We hypothesized that a well-balanced intake of total essential amino acids (EAAs) may be associated with lower prevalence of metabolic syndrome among Korean adults. This population-based cross-sectional study included 25,787 participants aged >= 30 years from the 2008-2019 Korea National Health and Nutrition Examination Survey. Dietary information was obtained from 24 h recall data. Demographic and lifestyle factors were assessed using self-administered questionnaires, and metabolic biomarkers were obtained from a health examination. Total essential amino acid score (EAAS) was calculated to determine whether essential amino acid (EAA) intake meets the recommended nutrient intake (RNI). Multivariable-adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using logistic regression models. After adjusting for multiple confounding factors, participants with higher EAAS had a significantly lower prevalence of high blood pressure (OR: 0.86, 95% CI: 0.75-0.98), hypertriglyceridemia (OR: 0.86, 95% CI: 0.76-0.98), and Metabolic syndrome (MetS) (OR: 0.86, 95% CI: 0.74-0.996). Spline regression analysis confirmed linearity of the association between total EAAS and MetS. EAA intake and MetS are associated with an inverse dose-response relationship in which metabolic disease may be prevented when the overall EAA intake meets the RNI.
C1 [Im, Jihyun; Park, Kyong] Yeungnam Univ, Dept Food & Nutr, Gyongsan 38541, South Korea.
   [Park, Hyoungsu] Maeil Hlth Nutr Co Ltd, R&D Unit, Pyeongtaek 17714, South Korea.
C3 Yeungnam University
RP Park, K (corresponding author), Yeungnam Univ, Dept Food & Nutr, Gyongsan 38541, South Korea.
EM kypark@ynu.ac.kr
RI Park, Kyong/AFJ-9812-2022
OI Park, Kyong/0000-0002-4681-1584
FU National Research Foundation of Korea (NRF) - Ministry of Science, ICT,
   and Future Planning [2018M3A9F3081356, 2021R1A2C1007869]
FX This research was funded by the Bio andMedical Technology Development
   Program (grant number 2018M3A9F3081356) and the Basic Science Research
   Program(grant number 2021R1A2C1007869) through the National Research
   Foundation of Korea (NRF) funded by the Ministry of Science, ICT, and
   Future Planning. The funders had no role in the study design, data
   collection and analysis, decision to publish, or preparation of the
   manuscript.
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NR 48
TC 6
Z9 6
U1 0
U2 5
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD NOV
PY 2022
VL 14
IS 22
AR 4771
DI 10.3390/nu14224771
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 6K9ZQ
UT WOS:000887850700001
PM 36432458
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Polusani, SR
   Cortez, V
   Esparza, J
   Nguyen, HN
   Fan, HX
   Velagaleti, GVN
   Butler, MJ
   Kinney, MC
   Oyajobi, BO
   Habib, SL
   Asmis, R
   Medina, EA
AF Polusani, Srikanth R.
   Cortez, Valerie
   Esparza, Javier
   Nguyen, Huynh Nga
   Fan, Hongxin
   Velagaleti, Gopalrao V. N.
   Butler, Matthew J.
   Kinney, Marsha C.
   Oyajobi, Babatunde O.
   Habib, Samy L.
   Asmis, Reto
   Medina, Edward A.
TI Oxidatively modified low-density lipoproteins are potential mediators of
   proteasome inhibitor resistance in multiple myeloma
SO INTERNATIONAL JOURNAL OF CANCER
LA English
DT Article
DE metabolic syndrome; multiple myeloma; obesity; oxidized LDL; proteasome
   inhibitor resistance
ID CIRCULATING OXIDIZED LDL; METABOLIC SYNDROME; ATHEROSCLEROSIS;
   BORTEZOMIB; EBSELEN; STRESS; CELLS; RISK; SIZE
AB Proteasome inhibitor (PI) therapy has improved the survival of multiple myeloma (MM) patients. However, inevitably, primary or acquired resistance to PIs leads to disease progression; resistance mechanisms are unclear. Obesity is a risk factor for MM mortality. Oxidized LDL (OxLDL), a central mediator of atherosclerosis that is elevated in metabolic syndrome (co-occurrence of obesity, insulin resistance, dyslipidemia and hypertension), has been linked to an increased risk of solid cancers and shown to stimulate pro-oncogenic/survival signaling. We hypothesized that OxLDL is a mediator of chemoresistance and evaluated its effects on MM cell killing by PIs. OxLDL potently suppressed the ability of the boronic acid-based PIs bortezomib (BTZ) and ixazomib, but not the epoxyketone-based PI carfilzomib, to kill human MM cell lines and primary cells. OxLDL suppressed BTZ-induced inhibition of proteasome activity and induction of pro-apoptotic signaling. These cytoprotective effects were abrogated when lipid hydroperoxides (LOOHs) associated with OxLDL were enzymatically reduced. We also demonstrated the presence of OxLDL in the MM bone marrow microenvironment as well as numerous granulocytes and monocytes capable of cell-mediated LDL oxidation through myeloperoxidase. Our findings suggest that OxLDL may be a potent mediator of boronic acid-based PI resistance, particularly for MM patients with metabolic syndrome, given their elevated systemic levels of OxLDL. LDL cholesterol-lowering therapy to reduce circulating OxLDL, and pharmacologic targeting of LOOH levels or resistance pathways induced by the modified lipoprotein, could deepen the response to these important agents and offer clinical benefit to MM patients with metabolic syndrome.
C1 [Polusani, Srikanth R.; Cortez, Valerie; Esparza, Javier; Fan, Hongxin; Velagaleti, Gopalrao V. N.; Kinney, Marsha C.; Medina, Edward A.] Univ Texas Hlth Sci Ctr San Antonio, Dept Pathol & Lab Med, Div Hematopathol, San Antonio, TX 78229 USA.
   [Nguyen, Huynh Nga] Univ Texas Hlth Sci Ctr San Antonio, Dept Biochem & Struct Biol, San Antonio, TX 78229 USA.
   [Butler, Matthew J.] Univ Texas Hlth Sci Ctr San Antonio, Dept Med, Div Hematol & Med Oncol, San Antonio, TX 78229 USA.
   [Oyajobi, Babatunde O.; Habib, Samy L.] Univ Texas Hlth Sci Ctr San Antonio, Dept Cell Syst & Anat, San Antonio, TX 78229 USA.
   [Habib, Samy L.] South Texas Vet Healthcare Syst, San Antonio, TX USA.
   [Asmis, Reto] Wake Forest Sch Med, Dept Internal Med, Winston Salem, NC 27101 USA.
C3 University of Texas System; University of Texas Health Science Center at
   San Antonio; University of Texas System; University of Texas Health
   Science Center at San Antonio; University of Texas System; University of
   Texas Health Science Center at San Antonio; University of Texas System;
   University of Texas Health Science Center at San Antonio; Wake Forest
   University
RP Medina, EA (corresponding author), Univ Texas Hlth Sci Ctr San Antonio, Sch Med, Dept Pathol & Lab Med, 7703 Floyd Curl Dr, San Antonio, TX 78229 USA.
EM medinae2@uthscsa.edu
RI Polusani, Srikanth/H-7318-2015; Asmis, Reto/W-1344-2019
OI Medina, Edward A./0000-0002-1305-4046; Oyajobi,
   Babatunde/0000-0002-1064-3072
FU Cancer Prevention and Research Institute of Texas [RP140105]; Max and
   Minnie Tomerlin Voelcker Fund; National Cancer Institute [R21 CA227414];
   National Center for Complementary and Integrative Health [RO1 AT006885];
   National Institute of General Medical Sciences [K12GM 111726]; San
   Antonio Area Foundation
FX Cancer Prevention and Research Institute of Texas, Grant/Award Number:
   Research Training Award RP140105; Max and Minnie Tomerlin Voelcker Fund;
   National Cancer Institute, Grant/Award Number: R21 CA227414; National
   Center for Complementary and Integrative Health, Grant/Award Number: RO1
   AT006885; National Institute of General Medical Sciences, Grant/Award
   Number: K12GM 111726; San Antonio Area Foundation
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NR 31
TC 4
Z9 6
U1 1
U2 12
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0020-7136
EI 1097-0215
J9 INT J CANCER
JI Int. J. Cancer
PD JUN 15
PY 2021
VL 148
IS 12
BP 3032
EP 3040
DI 10.1002/ijc.33497
EA MAR 2021
PG 9
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA RP2EO
UT WOS:000626128300001
PM 33521927
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Gomes, ÉVD
   Vasconcelos, RD
   Coelho, NMF
   Almeida, LD
   Silva, DARD
   Cerqueira, MMBD
   Cerqueira, JMD
   Conçeicao, SD
   Soares, JDP
   Magalhaes, LBNC
   Lua, I
   Figueredo, ACMG
   Brito, VCSG
   Fernandes, SL
   Viana, DD
   Freitas, RPD
   Requiao, GM
   Lima, LAD
   Hayes, BK
   Pinheiro, IM
   Monçao, MM
   Souza, ACD
   da Cruz, SS
   Gomes, AMT
   Pimentel, RFW
   Nardes, BO
   Lopes, LC
   Bastos, NSSG
   D'Oliveira, A Jr
   Merces, MCD
   Coelho, JMF
AF Gomes, Erica Velasco Dias
   Vasconcelos, Rebeca de Souza
   Coelho, Natalia Maria Freitas
   Almeida, Lorena de Carvalho
   Silva, Dandara Almeida Reis da
   Cerqueira, Monique Magnavita Borba da Fonseca
   Cerqueira, Jeane Magnavita da Fonseca
   Conceicao, Sarah dos Santos
   Soares, Johelle de Santana Passos
   Magalhaes, Lucelia Batista Neves Cunha
   Lua, Iracema
   Figueredo, Ana Claudia Morais Godoy
   Brito, Vitoria Cezar Santos Goncalves
   Fernandes, Sandra Lucia
   Viana, Dayanne de Aguiar
   Freitas, Ruan Pablo Duarte
   Requiao, Gabriella Moreira
   Lima, Luiz Alberto da Silva
   Hayes, Barbara Kraychete
   Pinheiro, Isabelle Matos
   Moncao, Mauricio Mitsuo
   Souza, Antonio Carlos dos Santos
   da Cruz, Simone Seixas
   Gomes, Antonio Marcos Tosoli
   Pimentel, Rodrigo Fernandes Weyll
   Nardes, Barbara Oliveira
   Lopes, Leticia Costa
   Bastos, Neiva Sueli Santana Goncalves
   D'Oliveira, Argemiro
   Merces, Magno Conceicao das
   Coelho, Julita Maria Freitas
TI Diagnosis of metabolic syndrome in nursing professionals: An accuracy
   study
SO PLOS ONE
LA English
DT Article
ID PATHOPHYSIOLOGY; ASSOCIATION; PREVALENCE; MANAGEMENT; STRESS
AB Metabolic Syndrome (MetS) represents a group of cardiovascular risk factors. This article aims to evaluate the accuracy of the tools of MetS diagnosis in Nursing professionals from Primary Health Care (PHC) in Bahia, Brazil. A cross-sectional study with a random sample selected according to essential health information for the diagnostic of MetS. For MetS diagnostic, we used EGIR, NCEP-ATPIII, AACE, IDF, Barbosa et al. (2006), and IDF/AHA/NHLBI (defined as gold standard) definition. Sensitivity, specificity, predictive values, and likelihood ratio were estimated for each diagnostic tool and compared with the gold standard. Kappa statistic was used to determine the agreement between the diagnostic methods. One thousand one hundred and eleven nursing professionals were included in this study. Sensitivity varied from 15% to 95.1%, and specificity varied between 99.5% and 100%. IDF and Barbosa et al. (2006) definitions were more sensitive (95.1% and 92.8%, respectively), and EGIR, NCEP, ATP III, and IDF showed 100% specificity. IDF and Barbosa et al. (2006) use suitable metabolic syndrome identification and confirmation criteria. The highest agreement was found in the definition of the IDF, Barbosa et al. (2006) and the NCEP ATP III. Defining metabolic syndrome with a higher diagnostic accuracy could contribute to the screening and the early identification of nursing professionals with cardiovascular disease risk factors, which provide opportunities for appropriate prevention and treatment.
C1 [Gomes, Erica Velasco Dias; Vasconcelos, Rebeca de Souza; Coelho, Natalia Maria Freitas; Almeida, Lorena de Carvalho; Silva, Dandara Almeida Reis da; Cerqueira, Monique Magnavita Borba da Fonseca; Cerqueira, Jeane Magnavita da Fonseca; Pimentel, Rodrigo Fernandes Weyll; Merces, Magno Conceicao das; Coelho, Julita Maria Freitas] Univ Bahia State UNEB, Dept Life Sci, Salvador, BA, Brazil.
   [Conceicao, Sarah dos Santos] Univ Brasilia UnB, Sch Hlth Sci, Brasilia, DF, Brazil.
   [Soares, Johelle de Santana Passos] Fed Univ Bahia UFBA, Sch Odontol, Salvador, BA, Brazil.
   [Magalhaes, Lucelia Batista Neves Cunha] UniFTC, Dept Med, Sch Technol & Sci, Salvador, Brazil.
   [Lua, Iracema] State Univ Feira Santana UEFS, Dept Hlth, Feira De Santana, BA, Brazil.
   [Figueredo, Ana Claudia Morais Godoy] Univ Brasilia, Sch Hlth Sci, Brasilia, DF, Brazil.
   [Brito, Vitoria Cezar Santos Goncalves; Fernandes, Sandra Lucia; D'Oliveira, Argemiro; Merces, Magno Conceicao das] Fed Univ Bahia UFBA, Dept Hlth Sci, Salvador, BA, Brazil.
   [Viana, Dayanne de Aguiar; Freitas, Ruan Pablo Duarte; Requiao, Gabriella Moreira; Merces, Magno Conceicao das; Coelho, Julita Maria Freitas] Dom Pedro II Univ Ctr UNIDOMPEDRO, Dept Med, Salvador, BA, Brazil.
   [Lima, Luiz Alberto da Silva] Univ Estado Bahia, Dept Social Sci, Serrinha, BA, Brazil.
   [Hayes, Barbara Kraychete] Childrens Hosp Los Angeles, Los Angeles, CA USA.
   [Pinheiro, Isabelle Matos; Moncao, Mauricio Mitsuo] Fed Inst Educ Sci & Technol Bahia, Dept Technol & Sci, Salvador, BA, Brazil.
   [Souza, Antonio Carlos dos Santos] Fed Inst Educ Sci & Technol Bahia Salvador, Dept Informat Technol, Salvador, BA, Brazil.
   [da Cruz, Simone Seixas] Fed Univ Reconcavo Bahia UFRB, Dept Collect Hlth, Santo Antonio De Jesus, BA, Brazil.
   [Gomes, Antonio Marcos Tosoli] State Univ Rio de Janeiro UERJ, Sch Nursing, Rio De Janeiro, RJ, Brazil.
   [Pimentel, Rodrigo Fernandes Weyll] Univ Hosp Prof Edgard Santos HUPES, Salvador, BA, Brazil.
   [Nardes, Barbara Oliveira; Lopes, Leticia Costa; Bastos, Neiva Sueli Santana Goncalves] Fed Univ Bahia UFBA, Inst Hlth Sci, Salvador, BA, Brazil.
   [Coelho, Julita Maria Freitas] Fed Inst Educ Sci & Technol Bahia, Dept Teaching, Lauro de Freitas, BA, Brazil.
C3 Universidade de Brasilia; Universidade Federal da Bahia; Universidade
   Estadual de Feira de Santana; Universidade de Brasilia; Universidade
   Federal da Bahia; Universidade do Estado Bahia; Children's Hospital Los
   Angeles; Instituto Federal da Bahia (IFBA); Universidade do Estado do
   Rio de Janeiro; Universidade Federal da Bahia; Instituto Federal da
   Bahia (IFBA)
RP Gomes, ÉVD (corresponding author), Univ Bahia State UNEB, Dept Life Sci, Salvador, BA, Brazil.
EM enfa.ericavelasco@gmail.com
RI Cerqueira, Monique/HKV-5843-2023; gomes, erica/IAM-1895-2023; Merces,
   Magno/S-6649-2017; MAGALHÃES, LUCELIA/AAA-1378-2019; Lua,
   Iracema/AAR-2466-2021; Zambroni de Souza, Antonio/AFK-0852-2022; Gomes,
   A./Q-6844-2016
OI de Carvalho Almeida, Lorena/0000-0003-0141-9105; Duarte Freitas, Ruan
   Pablo/0000-0001-9881-7016
FU Conselho Nacional de Desenvolvimento Cientfico e Tecnolgico; State
   University of Bahia, Feira de Santana State University; State University
   of Rio de Janeiro
FX The authors are grateful to the partnership of the State University of
   Bahia, Feira de Santana State University, Federal University of Bahia,
   and State University of Rio de Janeiro for their support in several
   stages of the project.
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NR 38
TC 2
Z9 2
U1 0
U2 0
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JUN 10
PY 2024
VL 19
IS 6
AR e0295985
DI 10.1371/journal.pone.0295985
PG 17
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA TX2P6
UT WOS:001244495600068
PM 38857224
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Cherniack, EP
AF Cherniack, E. Paul
TI Polyphenols: Planting the seeds of treatment for the metabolic syndrome
SO NUTRITION
LA English
DT Review
DE Polyphenol; Metabolic syndrome
ID GREEN TEA POLYPHENOL; PULP PREPARATION RICH; MEDIATED OXIDATIVE STRESS;
   INSOLUBLE DIETARY FIBER; REDUCES BLOOD-PRESSURE; INSULIN-RESISTANCE;
   CARDIOVASCULAR-DISEASE; ENDOTHELIAL FUNCTION; PROINFLAMMATORY CYTOKINES;
   ADIPOCYTE DIFFERENTIATION
AB Greater understanding about the pathogenesis of metabolic syndrome and potential causes suggests that plant polyphenols might be useful as a treatment. Dietary excess energy can be stored in adipocytes, leading to the release of proinflammatory cytokines and adipose-related hormones that cause vascular injury. Plant polyphenols, organic compounds found in numerous plant species and their fruits, are being actively studied as potential treatments for components of the metabolic syndrome. Individual polyphenols that have been examined include resveratrol, quercetin, epigallocathechin-3-gallate, and curcumin. Resveratrol lowers weight, blood pressure, glucose, and insulin resistance in rodents, and a human trial is currently underway. Quercetin decreases lipid and glucose levels in obese rats, and in a human investigation of subjects with the metabolic syndrome has lowered blood pressure without significant alteration of lipids. Epigallocathechin-3-gallate-induced weight loss has attenuated glucose levels and insulin resistance in rodents and improved hemoglobin A(1c) and lipid in human studies. Plant extracts also can be used. Grape seed and chokeberry extracts have decreased blood pressure and lipid levels in small human trials. Other human investigations have shown the beneficial effects of cocoa, coffee, carob, and Momordica charantia. Thus far, most studies have involved a small number of subjects and have been of short duration. Future studies should be designed to account for a disease process in which the pathogenic factors may take place for years before disease manifestations take place, the possibly limited bioavailability of polyphenols, and the potential need to provide combinations or modifications of polyphenols. Published by Elsevier Inc.
C1 [Cherniack, E. Paul] Univ Miami, Miller Sch Med, Dept Med, Geriatr Inst,Div Gerontol & Geriatr Med, Miami, FL 33136 USA.
   [Cherniack, E. Paul] Bruce W Carter Vet Affairs Med Ctr, Miami, FL USA.
C3 University of Miami
RP Cherniack, EP (corresponding author), Univ Miami, Miller Sch Med, Dept Med, Geriatr Inst,Div Gerontol & Geriatr Med, Miami, FL 33136 USA.
EM evan.cherniack@va.gov
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NR 97
TC 94
Z9 111
U1 3
U2 31
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0899-9007
EI 1873-1244
J9 NUTRITION
JI Nutrition
PD JUN
PY 2011
VL 27
IS 6
BP 617
EP 623
DI 10.1016/j.nut.2010.10.013
PG 7
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA V44LJ
UT WOS:000209750200001
PM 21367579
DA 2025-06-11
ER

PT J
AU Tomaszewska, A
   Gonciarz, W
   Rechcinski, T
   Chmiela, M
   Kurdowska, AK
   Krupa, A
AF Tomaszewska, Agata
   Gonciarz, Weronika
   Rechcinski, Tomasz
   Chmiela, Magdalena
   Kurdowska, Anna K.
   Krupa, Agnieszka
TI Helicobacter pylori components increase the severity of metabolic
   syndrome and its hepatic manifestations induced by a high fat diet
SO SCIENTIFIC REPORTS
LA English
DT Article
DE Atherosclerosis; Metabolic syndrome; Helicobacter pylori; Endothelium
ID CORONARY-HEART-DISEASE; INTERCELLULAR-ADHESION MOLECULE-1;
   LIVER-DISEASE; CARDIOVASCULAR-DISEASE; IMMUNE-RESPONSE; RISK-FACTORS;
   INFECTION; ATHEROSCLEROSIS; INFLAMMATION; CHOLESTEROL
AB The metabolic syndrome, often accompanied by hepatic manifestations, is a high-risk factor for developing cardiovascular disease. Patients with metabolic dysfunction associated with steatohepatic disease (MASDL) are at significant risk of developing coronary artery disease. Atherosclerosis is a systemic inflammatory disorder in which several factors, including dietary or infectious factors, can cause an inflammatory response. Helicobacter pylori (HP) bacteria have been implicated in the progression of proatherogenic vascular endothelial lesions, moreover, our previous study in an experimental in vivo model of Cavia porcellus showed that HP components and high-fat substances acted synergistically in promoting vascular endothelial inflammation, leading to an early onset of a proatherogenic environment. In the present study, our goal was to determine the contribution of HP components to the development of hepatic manifestations of metabolic syndrome in an experimental model. Our results showed that HP infection in animals exposed to a high-fat diet increased oxidative stress and lipid peroxidation, followed by endothelial lipid deposition, impaired endothelial apoptosis, cell lysis, and increased vascular stiffness. Finally, histopathological analysis of liver tissue showed signs of MASLD development in HP-infected animals fed a high-fat diet.
C1 [Tomaszewska, Agata; Gonciarz, Weronika; Chmiela, Magdalena; Krupa, Agnieszka] Univ Lodz, Fac Biol & Environm Protect, Dept Immunol & Infect Biol, Lodz, Poland.
   [Tomaszewska, Agata] Univ Lodz, Biomed Chem Doctoral Sch, Lodz, Poland.
   [Tomaszewska, Agata] Univ Lodz, Polish Acad Sci, Lodz Inst, Lodz, Poland.
   [Rechcinski, Tomasz] Med Univ Lodz, Dept Cardiol 1, Lodz, Poland.
   [Kurdowska, Anna K.] Univ Texas Hlth Sci Ctr Tyler, Dept Cellular & Mol Biol, Tyler, TX USA.
C3 University of Lodz; University of Lodz; Polish Academy of Sciences;
   University of Lodz; Medical University Lodz; University of Texas System;
   University of Texas-Health Sciences Center at Tyler (UTHSCT)
RP Tomaszewska, A; Krupa, A (corresponding author), Univ Lodz, Fac Biol & Environm Protect, Dept Immunol & Infect Biol, Lodz, Poland.; Tomaszewska, A (corresponding author), Univ Lodz, Biomed Chem Doctoral Sch, Lodz, Poland.; Tomaszewska, A (corresponding author), Univ Lodz, Polish Acad Sci, Lodz Inst, Lodz, Poland.
EM agata.tomaszewska@edu.uni.lodz.pl; agnieszka.krupa@biol.uni.lodz.pl
RI Gonciarz, Weronika/ABR-0147-2022; Krupa, Agnieszka/AFR-0905-2022;
   Rechcinski, Tomasz/S-9680-2016
OI Krupa, Agnieszka/0000-0003-1303-4608; Gonciarz,
   Weronika/0000-0002-5231-5341; Tomaszewska, Agata/0000-0003-4290-4115;
   Rechcinski, Tomasz/0000-0001-7800-785X
FU University of Lodz Initiative for Excellence - Research University -
   Doctoral Research Grants [8/DGB/IDUB/2022]
FX The research was funded by the University of Lodz Initiative for
   Excellence-Research University-Doctoral Research Grants project number
   8/DGB/IDUB/2022.
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NR 70
TC 6
Z9 6
U1 1
U2 4
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD MAR 8
PY 2024
VL 14
IS 1
AR 5764
DI 10.1038/s41598-024-56308-7
PG 15
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA KL1O8
UT WOS:001180027600006
PM 38459219
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Mommersteeg, PMC
   Vermetten, E
   Kavelaars, A
   Geuze, E
   Heijnen, CJ
AF Mommersteeg, Paula M. C.
   Vermetten, Eric
   Kavelaars, Annemieke
   Geuze, Elbert
   Heijnen, Cobi J.
TI Hostility is related to clusters of T-cell cytokines and chemokines in
   healthy men
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE hostility; cytokines; chemokines; factor analysis; risk factor; male
ID POSTTRAUMATIC-STRESS-DISORDER; CORONARY-ARTERY-DISEASE; PSYCHOSOCIAL
   FACTORS; DEPRESSIVE SYMPTOMS; METABOLIC SYNDROME; CYNICAL HOSTILITY;
   HEART-DISEASE; RISK-FACTORS; ANGER; INTERLEUKIN-6
AB Hostility is a risk factor for adverse health outcomes as diverse as cardiovascular disease and post-traumatic stress disorder (PTSD). Cytokines have been suggested to mediate this relationship. We investigated whether in healthy men a relation existed between hostility and T-cell mitogen-induced cytokines and chemokines. Mate Dutch military personnel (n = 304) were included before deployment. Eleven cytokines and chemokines were measured in supernatants of T-cell mitogen-stimulated whole blood cultures by multiplex immunoassay. Factor analysis was used to identify clusters of cytokines and chemokines. In a regression analysis hostility was related to the cytokine/chemokine clusters, and the potential risk factors age, BMI, smoking, drinking, previous deployment, early life trauma and depression.
   Explorative factor analysis showed four functional clusters; a pro-inflammatory factor (IL-2, TNF alpha, IFN-gamma), an anti-inflammatory factor (IL-4, IL-5, IL-10), IL-6/chemokine factor (IL-6, MCP-1, RANTES, IP-10), and MIF Hostility was significantly related to decreased IL-6/chemokine secretion and increased pro- and anti-inflammatory cytokines. There was an inverse relation between age and hostility scores. Early life trauma and depression were positively and independently related to hostility as well.
   This study represents a novel way of investigating the relation between cytokines and psychological characteristics. Cytokines/chemokines clustered into functional factors, which were related to hostility in healthy mates. Moreover this relation appeared to be independent of reported depression and early trauma. (c) 2008 Elsevier Ltd. All rights reserved.
C1 [Mommersteeg, Paula M. C.; Kavelaars, Annemieke; Heijnen, Cobi J.] Univ Med Ctr Utrecht, Lab Psychoneuroimmunol, NL-3584 EA Utrecht, Netherlands.
   [Vermetten, Eric; Geuze, Elbert] Minist Def, Mil Mental Healthcare, Res Ctr, Utrecht, Netherlands.
   [Mommersteeg, Paula M. C.] Tilburg Univ, CoRPS Ctr Res Psychol Somat Dis, NL-5000 LE Tilburg, Netherlands.
C3 Utrecht University; Utrecht University Medical Center; Tilburg
   University
RP Heijnen, CJ (corresponding author), Univ Med Ctr Utrecht, Lab Psychoneuroimmunol, KC03-068-0,Lundlaan 6, NL-3584 EA Utrecht, Netherlands.
EM c.heijnen@umcutrecht.nl
RI Geuze, Elbert/AET-0833-2022; Vermetten, Eric/B-1335-2008
OI Geuze, Elbert/0000-0003-3479-2379; Vermetten, Eric/0000-0003-0579-4404
FU Ministry of Defense of The Netherlands
FX This study was subsidized by a grant from the Ministry of Defense of The
   Netherlands. The authors are greatly indebted to Cot MD C. IJzerman and
   the commanders and troops for their time and effort. We thank Kim
   Kroezen for organizing inclusion of the participants. We also thank
   Karima Amarouchi, Linda Schild, Hanneke Willemen, Marijke
   Tersteeg-Kamperman, Esther Rudolph, Mirjam Maas, and Jitske Zijlstra for
   excellent technical assistance in the framework of the PRISMO project.
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NR 44
TC 36
Z9 40
U1 0
U2 13
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD SEP
PY 2008
VL 33
IS 8
BP 1041
EP 1050
DI 10.1016/j.psyneuen.2008.05.007
PG 10
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA 353QO
UT WOS:000259583500002
PM 18640786
DA 2025-06-11
ER

PT J
AU Arbo, BD
   Niches, G
   Zanini, P
   Bassuino, DM
   Driemeier, D
   Ribeiro, MF
   Cecconello, AL
AF Arbo, B. D.
   Niches, G.
   Zanini, P.
   Bassuino, D. M.
   Driemeier, D.
   Ribeiro, M. F.
   Cecconello, A. L.
TI Aging affects the response of female rats to a hypercaloric diet
SO EXPERIMENTAL GERONTOLOGY
LA English
DT Article
DE Obesity; Metabolic syndrome; Dyslipidemia; Insulin resistance; Hepatic
   damage
ID FATTY LIVER-DISEASE; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   PHYSICAL-EXERCISE; OXIDATIVE STRESS; INDUCED OBESITY; GENDER;
   SUPPLEMENTATION; DYSLIPIDEMIA; MECHANISMS
AB Metabolic syndrome is a major risk factor for the development of cardiovascular diseases and diabetes, among other conditions. Studies have shown that aging and metabolic syndrome share several metabolic alterations, and that aged individuals, in particular females, are at an increased risk of developing metabolic disorders. Although several studies have investigated the effects of hypercaloric diets in the development of obesity and metabolic syndrome in young animals, few studies have investigated these parameters in aged animals, especially in females. Therefore, the aim of this study was to investigate the effects of a hypercaloric diet in metabolic parameters of young and aged female rats, including its effects on lipid and glycemic profile and on liver lipid content. When compared to young animals, the aged rats presented increased serum levels of triglycerides and decreased serum levels of HDL cholesterol and glycemia, as well as increased hepatic levels of triglycerides and total cholesterol. The hypercaloric diet increased food intake, body weight gain and adiposity index, leading both young and aged animals to a dyslipidemia, represented by increased serum levels of triglycerides. The hypercaloric diet increased the glycemia and the HOMA index only in the young animals. On the other hand, the diet increased the frequency of hepatocellular microvacuolar degeneration only in the aged animals. In summary, it was observed that the females from different ages respond differently to hypercaloric diet intake: while the aged animals were more resistant to the changes in the glycemic profile, they were more susceptible to the hepatic damage caused by this diet.
C1 [Arbo, B. D.; Niches, G.; Zanini, P.; Ribeiro, M. F.; Cecconello, A. L.] Univ Fed Rio Grande do Sul, ICBS, Dept Physiol, Lab Interacao Neurohumoral, Rua Sarmento Leite 500, BR-90050170 Porto Alegre, RS, Brazil.
   [Arbo, B. D.] Univ Fed Rio Grande do Sul, ICBS, Programa Posgrad Ciencias Biol Farmacol & Terapeu, Rua Sarmento Leite 500, BR-90050170 Porto Alegre, RS, Brazil.
   [Bassuino, D. M.] Univ Fed Rio Grande do Sul, Sch Vet, Dept Vet Clin Pathol, Setor Patol Vet, Av Bento Goncalves 9090, BR-91540000 Porto Alegre, RS, Brazil.
C3 Universidade Federal do Rio Grande do Sul; Universidade Federal do Rio
   Grande do Sul; Universidade Federal do Rio Grande do Sul
RP Arbo, BD (corresponding author), Univ Fed Rio Grande do Sul, ICBS, Programa Posgrad Ciencias Biol Farmacol & Terapeu, Rua Sarmento Leite 500, BR-90050170 Porto Alegre, RS, Brazil.
EM brunoarbo@gmail.com
RI Arbo, Bruno/T-2263-2017; Driemeier, David/H-3461-2012
OI Driemeier, David/0000-0003-3766-0654; Niches da Silva,
   Gabriela/0000-0001-7113-4856; Mariath Bassuino,
   Daniele/0000-0002-7724-3639; Marques Ribeiro, Maria
   Flavia/0000-0002-2265-7332; Arbo, Bruno/0000-0001-7929-1688
FU Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES);
   Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
FX Bruno D. Arbo received a PNPD scholarship from Coordenacao de
   Aperfeicoamento de Pessoal de Nivel Superior (CAPES). Maria Flavia M.
   Ribeiro received an 1D Researcher Productivity Grant from Conselho
   Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq).
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NR 34
TC 3
Z9 3
U1 0
U2 6
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0531-5565
EI 1873-6815
J9 EXP GERONTOL
JI Exp. Gerontol.
PD JAN
PY 2018
VL 101
BP 7
EP 12
DI 10.1016/j.exger.2017.11.008
PG 6
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA FV9QA
UT WOS:000424922000002
PM 29133011
DA 2025-06-11
ER

PT J
AU Lin, HQ
   Williams, KA
   Katsovich, L
   Findley, DB
   Grantz, H
   Lombroso, PJ
   King, RA
   Bessen, DE
   Johnson, D
   Kaplan, EL
   Landeros-Weisenberger, A
   Zhang, HP
   Leckman, JF
AF Lin, Haiqun
   Williams, Kyle A.
   Katsovich, Liliya
   Findley, Diane B.
   Grantz, Heidi
   Lombroso, Paul J.
   King, Robert A.
   Bessen, Debra E.
   Johnson, Dwight
   Kaplan, Edward L.
   Landeros-Weisenberger, Angeli
   Zhang, Heping
   Leckman, James F.
TI Streptococcal Upper Respiratory Tract Infections and Psychosocial Stress
   Predict Future Tic and Obsessive-Compulsive Symptom Severity in Children
   and Adolescents with Tourette Syndrome and Obsessive-Compulsive Disorder
SO BIOLOGICAL PSYCHIATRY
LA English
DT Article
DE Attention-deficit/hyperactivity disorder; obsessive-compulsive disorder
   x Tourette syndrome x tic x group A beta hemolytic streptococcal upper
   respiratory tract infections; major depressive disorder (MDD); PANDAS;
   structural equation modeling
ID ANTISTREPTOCOCCAL ANTIBODY-TITERS; MYCOPLASMA-PNEUMONIAE INFECTION;
   BASAL GANGLIA ANTIBODIES; PSYCHOLOGICAL STRESS; LIFE EVENTS;
   EXACERBATIONS; PANDAS; SCALE; RESPONSIVITY; RELIABILITY
AB Background: One goal of this prospective longitudinal study was to identify new group A beta-hemolytic streptococcal infections (GABHS) in children and adolescents with burette syndrome (TS) and/or obsessive-compulsive disorder (OCD) compared with healthy control subjects. We then examined the power of GABHS infections and measures of psychosocial stress to predict future tic, obsessive-compulsive (OC), and depressive symptom severity.
   Methods: Consecutive ratings of tic, OC, and depressive symptom severity were obtained for 45 cases and 41 matched control subjects over a 2-year period. Clinical raters were blinded to the results of laboratory tests. Laboratory personnel were blinded to case or control status and clinical ratings. Structural equation modeling for unbalanced repeated measures was used to assess the sequence of new GABHS infections and psychosocial stress and their impact on future symptom severity.
   Results: Increases in tic and OC symptom severity did not occur after every new GABHS infection. However, the structural equation model found that these newly diagnosed infections were predictive of modest increases in future tic and OC symptom severity but did not predict future depressive symptom severity. In addition, the inclusion of new infections in the model greatly enhanced, by a factor of three, the power of psychosocial stress in predicting future tic and OC symptom severity.
   Conclusions: Our data suggest that a minority of children with IS and early-onset OCD were sensitive to antecedent GABHS infections. These infections also enhanced the predictive power of current psychosocial stress on future tic and OC symptom severity.
C1 [Williams, Kyle A.; Katsovich, Liliya; Findley, Diane B.; Grantz, Heidi; Lombroso, Paul J.; King, Robert A.; Landeros-Weisenberger, Angeli; Zhang, Heping; Leckman, James F.] Yale Univ, Sch Med, Ctr Child Study, Yale Ctr Clin Invest, New Haven, CT 06520 USA.
   [Lin, Haiqun; Zhang, Heping] Yale Univ, Sch Med, Dept Epidemiol & Publ Hlth, Yale Ctr Clin Invest, New Haven, CT 06520 USA.
   [Bessen, Debra E.] New York Med Coll, Dept Microbiol & Immunol, Valhalla, NY 10595 USA.
   [Johnson, Dwight; Kaplan, Edward L.] Univ Minnesota, Sch Med, Dept Pediat, Streptococcal Reference Lab,World Hlth Org, Minneapolis, MN 55455 USA.
C3 Yale University; Yale University; New York Medical College; University
   of Minnesota System; University of Minnesota Twin Cities; World Health
   Organization
RP Leckman, JF (corresponding author), Yale Univ, Sch Med, Ctr Child Study, Yale Ctr Clin Invest, New Haven, CT 06520 USA.
EM james.leckman@yale.edu
RI Leckman, James/O-2426-2015; Zhang, Heping/JOZ-2696-2023
OI Leckman, James/0000-0002-3902-4478; Lin, Haiqun/0000-0002-3114-9671;
   Zhang, Heping/0000-0002-0688-4076
FU Touretter Syndrome Association; Donaghue Medical Research Foundation;
   Yale School of Medicine; Echlin Foundation; Rembrandt Foundation; Brian
   Richmand; Kaiser Family; National Institute of Health [MH066187,
   P01MH049351, R01MH061940, R01NS42240, MH014235, K05 MH076273, K02
   MH01527, DA017713, DA076750, M0TRR006022, RR00125]
FX This research was funded in part by the Touretter Syndrome Association
   (DB), the Donaghue Medical Research Foundation, the Yale School of
   Medicine (JFL), the Echlin Foundation, the Rembrandt Foundation, Brian
   Richmand, and the Kaiser Family. This research was also supported by
   National Institute of Health Grant Nos. MH066187, P01MH049351 (JFL),
   R01MH061940 (JFL), R01NS42240, MH014235, K05 MH076273 (JFL), K02 MH01527
   (PJL), DA017713, DA076750, M0TRR006022, and RR00125. The authors also
   wish to thank Virginia Eicher, Susan Quatrano, Nancy Thompson, and
   Barbara Peterson-Cremer for their invaluable assistance in completing
   this study.
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NR 66
TC 58
Z9 68
U1 0
U2 11
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0006-3223
EI 1873-2402
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD APR 1
PY 2010
VL 67
IS 7
BP 684
EP 691
DI 10.1016/j.biopsych.2009.08.020
PG 8
WC Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA 574QY
UT WOS:000276008700013
PM 19833320
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Patel, KP
   Maheshwari, RA
AF Patel, Kinjal P.
   Maheshwari, Rajesh A.
TI Modulatory Effects of Passiflora edulis on Liver Function,
   Lipid Profile and Adipokines in Fructose-Induced Metabolic Syndrome in
   Rats
SO PHARMACOGNOSY RESEARCH
LA English
DT Article
DE Adipolines; Fructose; Hepatic Enzymes; Histopathological Analysis; Lipid
   Profile; Metabolic Syndrome
ID INSULIN-RESISTANCE; INFLAMMATION; CHOLESTEROL; STRESS
AB Background: This research explores the restorative effects of Passiflora edulis extract counter to liver damage and metabolic disruptions caused by a high-fructose diet in female Wistar rats. Materials and Methods: The consumption of fructose resulted in increased levels of hepatic enzymes, signaling liver damage, along with notable changes in the lipid profile, including TG, TC and LDL and HDL all of which are characteristic of metabolic syndrome. Doses of 250, 500 and 1000 mg/kg of the Passiflora edulis extract were administered to evaluate its therapeutic potential. Results: The results demonstrated that extract meaningfully dropped SGPT and SGOT levels, suggesting liver protection, particularly at the higher doses (500 and 1000 mg/ kg). However, the 250 mg/kg dose did not have a substantial outcome on ALP levels, indicating that a higher dosage is needed for optimal liver protection. Additionally, extract improved lipid profiles by falling TG, TC and LDL levels, while boosting HDL, indicating its potential to correct lipid imbalances associated with metabolic syndrome. At higher doses, extract also improved adipokines levels, increasing adiponectin and decreasing leptin and resistin, which are linked to better insulin sensitivity and reduced inflammation. Histopathological analysis showed that extract mitigated liver damage, with the most significant improvement observed at the 1000 mg/kg dose, where the liver tissue appeared almost normal. Conclusion: These results suggest that extract has beneficial effects on liver function and metabolic disturbances, predominantly at higher doses, positioning it as a hopeful substance for treating metabolic syndrome-related conditions. Subsequent studies are needed to evaluate the underlying mechanisms and assess the long-term effects of extract in metabolic diseases.
C1 [Patel, Kinjal P.; Maheshwari, Rajesh A.] Sumandeep Vidyapeeth, Dept Pharm, Vadodara, Gujarat, India.
C3 Sumandeep Vidyapeeth
RP Patel, KP (corresponding author), Sumandeep Vidyapeeth, Dept Pharm, Vadodara 391760, Gujarat, India.
EM kinjalpatel54@gmail.com
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NR 22
TC 0
Z9 0
U1 0
U2 0
PU PHCOG NET
PI KARNATAKA
PA 17, 2ND FLR, BUDDHA VIHAR RD, NEAR SPORTS ZONE, COX TOWN, BENGALURU,
   KARNATAKA, 560005, INDIA
SN 0974-8490
EI 0976-4836
J9 PHARMACOGN RES
JI Pharmacogn. Res.
PD APR-JUN
PY 2025
VL 17
IS 2
BP 571
EP 576
DI 10.5530/pres.20252058
PG 6
WC Pharmacology & Pharmacy
WE Emerging Sources Citation Index (ESCI)
SC Pharmacology & Pharmacy
GA 2DP1I
UT WOS:001480124200021
DA 2025-06-11
ER

PT J
AU Xue, RQ
   Yu, XJ
   Zhao, M
   Xu, M
   Wu, Q
   Cui, YL
   Yang, S
   Li, DL
   Zang, WJ
AF Xue, Run-Qing
   Yu, Xiao-Jiang
   Zhao, Ming
   Xu, Man
   Wu, Qing
   Cui, Yan-Ling
   Yang, Si
   Li, Dong-Ling
   Zang, Wei-Jin
TI Pyridostigmine alleviates cardiac dysfunction via improving
   mitochondrial cristae shape in a mouse model of metabolic syndrome
SO FREE RADICAL BIOLOGY AND MEDICINE
LA English
DT Article
DE Metabolic syndrome; Cardiac dysfunction; Mitochondrial cristae shape;
   Pyridostigmine
ID IMPAIRED GLUCOSE-TOLERANCE; INSULIN SENSITIVITY; HIGH-FAT; STIMULATION;
   DYNAMICS; FISSION; PATHWAY; STRESS; PROTECTS; DISEASE
AB Insulin resistance and autonomic imbalance are important pathological processes in metabolic syndrome-induced cardiac remodeling. Recent studies determined that disruption of mitochondrial cristae shape is associated with myocardial ischemia; however, the change in cristae shape in metabolic syndrome-induced cardiac remodeling remains unclear. This study determined the effect of pyridostigmine (PYR), which reversibly inhibits cholinesterase to improve autonomic imbalance, on high-fat diet (HFD)-induced cardiac insulin resistance and explored the potential effect on the shape of mitochondrial cristae. Feeding of a HFD for 22 weeks led to an irregular and even lysed cristae structure in cardiac mitochondria, which contributed to decreased mitochondrial content and ATP production and increased oxygen species production, ultimately impairing insulin signaling and lipid metabolism. Interestingly, PYR enhanced vagal activity by increasing acetylcholine production and exerted mito-protective effects by activating the LKB1/AMPK/ACC signal pathway. Specifically, PYR upregulated OPA1 and Mfn1/2 expression, promoted the formation of the mitofilin/CHCHD3/Sam50 complex, and decreased p-Drp1 and Fis1 expression, resulting in tight and parallel cristae and increasing cardiac mitochondrial complex subunit expression and ATP generation as well as decreasing release of cytochrome C from mitochondria and oxidative damage. Furthermore, PYR improved glucose and insulin tolerance and insulin-stimulated Akt phosphorylation, decreased lipid toxicity, and ultimately ameliorated HFD-induced cardiac remodeling and dysfunction. In conclusion, PYR prevented cardiac and insulin insensitivity and remodeling by stimulating vagal activity to regulate mitochondrial cristae shape and function in HFD-induced metabolic syndrome in mice. These results provide novel insights for the development of a therapeutic strategy for obesity-induced cardiac dysfunction that targets mitochondrial cristae.
C1 [Xue, Run-Qing; Yu, Xiao-Jiang; Zhao, Ming; Xu, Man; Wu, Qing; Cui, Yan-Ling; Yang, Si; Li, Dong-Ling; Zang, Wei-Jin] Xi An Jiao Tong Univ, Sch Basic Med Sci, Dept Pharmacol, Hlth Sci Ctr, POB 77,76 Yanta West Rd, Xian 710061, Shaanxi, Peoples R China.
C3 Xi'an Jiaotong University
RP Li, DL; Zang, WJ (corresponding author), Xi An Jiao Tong Univ, Sch Basic Med Sci, Dept Pharmacol, Hlth Sci Ctr, POB 77,76 Yanta West Rd, Xian 710061, Shaanxi, Peoples R China.
EM lidl@xjtu.edu.cn; zwj@xjtu.edu.cn
FU National Natural Science Foundation of China [81770293, 81473203]
FX This research was supported by grants from the National Natural Science
   Foundation of China (Nos. 81770293; 81473203).
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NR 46
TC 26
Z9 26
U1 0
U2 18
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0891-5849
EI 1873-4596
J9 FREE RADICAL BIO MED
JI Free Radic. Biol. Med.
PD APR
PY 2019
VL 134
BP 119
EP 132
DI 10.1016/j.freeradbiomed.2019.01.011
PG 14
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA ID6WQ
UT WOS:000471822700011
PM 30633969
DA 2025-06-11
ER

PT J
AU Ichimura, M
   Kato, S
   Tsuneyama, K
   Matsutake, S
   Kamogawa, M
   Hirao, E
   Miyata, A
   Mori, S
   Yamaguchi, N
   Suruga, K
   Omagari, K
AF Ichimura, Mayuko
   Kato, Shigeko
   Tsuneyama, Koichi
   Matsutake, Sachiko
   Kamogawa, Mai
   Hirao, Eri
   Miyata, Ayako
   Mori, Sawako
   Yamaguchi, Noriaki
   Suruga, Kazuhito
   Omagari, Katsuhisa
TI Phycocyanin prevents hypertension and low serum adiponectin level in a
   rat model of metabolic syndrome
SO NUTRITION RESEARCH
LA English
DT Article
DE Phycocyanin; Metabolic syndrome; Hypertension; Endothelial nitric oxide
   synthase; Adiponectin; SHR/NDmcr-cp rats
ID SHR/NDMCR-CP RATS; ACTIVATED RECEPTOR-GAMMA; NONALCOHOLIC
   STEATOHEPATITIS; SPIRULINA-PLATENSIS; ENDOTHELIAL DYSFUNCTION;
   MECHANISMS; OBESITY; ANTIOXIDANT; INSULIN; STRESS
AB Endothelial dysfunction is associated with hypertension, atherosclerosis, and metabolic syndrome. Phycocyanin is a pigment found in the blue-green algae, Spirulina, which possesses antihypertensive effect. In this study, we hypothesized that phycocyanin derived from Spirulina exerts antihypertensive actions by improving endothelial dysfunction in metabolic syndrome. Spontaneously hypertensive/NIH-corpulent (SHR/NDmcr-cp) rats were divided into 4 groups then fed a normal diet with or without phycocyanin (2500-, 5000-, or 10 000-mg/kg diet) for 25 weeks. At 34 weeks of age, although systolic blood pressure was not significantly different among groups, phycocyanin-fed groups exhibited a dose-dependent decrease in blood pressure. Serum levels of adiponectin and messenger RNA levels of adiponectin and CCAAT/enhancer-binding protein a in the adipose tissue of rats fed diets containing phycocyanin tended to be higher than those of rats fed a normal diet, but the differences were not statistically significant. Immunohistochemistry analysis showed a significant and positive correlation between aortic endothelial nitric oxide synthase (eNOS) expression levels, a downstream target of the adiponectin receptor, and serum adiponectin levels, although there were no significant differences in eNOS expression among groups. There was also no significant correlation between eNOS expression levels and systolic blood pressure. These results suggest that long-term administration of phycocyanin may ameliorate systemic blood pressure by enhancing eNOS expression in aorta that is stimulated by adiponectin. Phycocyanin may be beneficial for preventing endothelial dysfunction-related diseases in metabolic syndrome. (C) 2013 Elsevier Inc. All rights reserved.
C1 [Ichimura, Mayuko; Kato, Shigeko; Matsutake, Sachiko; Yamaguchi, Noriaki; Suruga, Kazuhito; Omagari, Katsuhisa] Nagasaki Univ, Grad Sch Human Hlth Sci, Div Nutr Sci, Siebold, Nagasaki 8512195, Japan.
   [Kato, Shigeko; Kamogawa, Mai; Hirao, Eri; Miyata, Ayako; Mori, Sawako; Yamaguchi, Noriaki; Suruga, Kazuhito; Omagari, Katsuhisa] Nagasaki Univ, Fac Nursing & Nutr, Div Nutr Sci, Siebold, Nagasaki, Japan.
   [Tsuneyama, Koichi] Toyama Univ, Dept Diagnost Pathol, Toyama 930, Japan.
C3 Nagasaki University; Nagasaki University; University of Toyama
RP Omagari, K (corresponding author), Nagasaki Univ, Grad Sch Human Hlth Sci, Div Nutr Sci, 1-1-1 Manabino, Siebold, Nagasaki 8512195, Japan.
EM omagari@sun.ac.jp
RI Ichimura-Shimizu, Mayuko/KFT-1304-2024
OI Ichimura-Shimizu, Mayuko/0000-0003-4030-1249; Tsuneyama,
   Koichi/0000-0002-0670-9868
FU University of Nagasaki; DIC Lifetec Co, Ltd.; Grants-in-Aid for
   Scientific Research [24390181, 24614011] Funding Source: KAKEN
FX The authors thank Mitsuteru Ishiwara, DIC Lifetec Co, Ltd., for
   providing phycocyanin and for his helpful advice. This work was
   supported by research funds from the University of Nagasaki and a
   research grant from DIC Lifetec Co, Ltd. M. Ichimura, S. Kato, and K.
   Omagari received support from a grant from the DIC Lifetec Co., Ltd. K.
   Tsuneyama, S. Matsutake, M. Kamogawa, E Hirao, A. Miyata, S. Mori, N.
   Yamaguchi, and K. Suruga have no conflict of interest to declare.
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NR 28
TC 67
Z9 70
U1 0
U2 41
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0271-5317
J9 NUTR RES
JI Nutr. Res.
PD MAY
PY 2013
VL 33
IS 5
BP 397
EP 405
DI 10.1016/j.nutres.2013.03.006
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 156XF
UT WOS:000319856500007
PM 23684441
DA 2025-06-11
ER

PT J
AU Troxel, WM
   Matthews, KA
   Gallo, LC
   Kuller, LH
AF Troxel, WM
   Matthews, KA
   Gallo, LC
   Kuller, LH
TI Marital quality and occurrence of the metabolic syndrome in women
SO ARCHIVES OF INTERNAL MEDICINE
LA English
DT Article; Proceedings Paper
CT 62nd Annual Meeting of the American-Psychosomatic-Society
CY MAR 03-06, 2004
CL Orlando, FL
SP Amer Psychosomat Soc
ID CORONARY HEART-DISEASE; CARDIOVASCULAR-DISEASE; INSULIN-RESISTANCE;
   HEALTH; MORTALITY; RISK; STRESS; MARRIAGE; IMPACT
AB Background: Marital status is associated with the early stages and progression of cardiovascular disease, an association that may stem in part from the influence of marital quality on metabolic factors. The objective of this study was to examine whether women reporting marital satisfaction are at reduced risk of developing the metabolic syndrome compared with other women.
   Methods: Four hundred thirteen middle-aged women from the Pittsburgh Healthy Women Study completed measures of marital status and marital satisfaction at baseline and 3 years later. Metabolic syndrome (diagnosed according to the criteria of the National Cholesterol Education Program) was assessed at baseline and at the last follow-up visit (an average of 11.5 years later).
   Results: Compared with maritally satisfied women, maritally dissatisfied (odds ratio [OR], 3.02; 95% confidence interval [CI], 1.46-6.24), divorced (OR, 2.47; 95% CI, 1.02-5.97), and widowed (OR, 5.82; 95% CI, 1.88-18.03) women were significantly more likely to have the metabolic syndrome at follow-up. The differences between maritally satisfied women and dissatisfied (OR, 3.18; 95% CI, 1.42-7.15) and widowed (OR, 5.69; 95% CI, 1.70-9.04) women remained significant in the full multivariate model. The difference between maritally satisfied women and divorced women (OR, 2.35; 95% CI, 0.896.18) was reduced to marginal significance in the full multivariate model. Single (OR, 2.84; 95% CI, 0.84-9.64) and moderately satisfied (OR, 1.06; 95% CI, 0.35-3.21) women did not differ significantly from maritally satisfied women.
   Conclusions: Women in high-quality marriages are at lower risk of developing the metabolic syndrome. Social histories of patients should include assessment of marital quality.
C1 Univ Pittsburgh, Dept Psychol, Pittsburgh, PA 15213 USA.
   Univ Pittsburgh, Dept Psychiat, Pittsburgh, PA 15213 USA.
   San Diego State Univ, Dept Psychol, San Diego, CA 92182 USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE); University
   of Pittsburgh; Pennsylvania Commonwealth System of Higher Education
   (PCSHE); University of Pittsburgh; California State University System;
   San Diego State University
RP Univ Pittsburgh, Dept Psychol, 3811 Ohara St, Pittsburgh, PA 15213 USA.
EM matthewska@upmc.edu
OI Gallo, Linda C./0000-0002-3678-5888
FU NHLBI NIH HHS [HL65111, HL28266, HL07560, HL65112] Funding Source:
   Medline
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NR 39
TC 102
Z9 117
U1 0
U2 8
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 0003-9926
EI 1538-3679
J9 ARCH INTERN MED
JI Arch. Intern. Med.
PD MAY 9
PY 2005
VL 165
IS 9
BP 1022
EP 1027
DI 10.1001/archinte.165.9.1022
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI); Conference Proceedings Citation Index - Science (CPCI-S)
SC General & Internal Medicine
GA 924ST
UT WOS:000229001400008
PM 15883241
DA 2025-06-11
ER

PT J
AU Choi, E
   Jang, E
   Lee, JH
AF Choi, Eunsol
   Jang, Eungyeong
   Lee, Jang-Hoon
TI Pharmacological Activities of Alisma orientale against
   Nonalcoholic Fatty Liver Disease and Metabolic Syndrome: Literature
   Review
SO EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Review
ID PREVALENCE
AB Nonalcoholic fatty liver disease (NAFLD) is a rapidly emerging hepatic manifestation of metabolic syndrome. However, its unrevealed mechanism and complicated comorbidities have led to no specific medication, except for weight loss and lifestyle modification. Alisma orientale (Sam.) Juzep (A. orientale, Alismataceae) has been increasingly reported on therapeutic effects of A. orientale against NAFLD and metabolic syndrome such as insulin resistance, hyperlipidemia, and obesity. Therefore, this study aimed to review the preclinical efficacy of A. orientale and its chemical constituents including Alisol A 24-acetate, Alisol B 23-acetate, Alisol F, and Alismol against NAFLD and metabolic syndrome. A. orientale prevented hepatic triglyceride accumulation through suppressing de novo lipogenesis and increasing lipid export. In addition, it controlled oxidative stress markers, lipoapoptosis, liver injury panels, and inflammatory and fibrotic mediators, eventually influencing steatohepatitis and liver fibrosis. Moreover, it exhibited pharmacological activities against hyperlipidemia, obesity, and hyperglycemia as well as appetite. These biological actions of A. orientale might contribute to adiponectin activation or a role as a farnesoid X receptor agonist. In particular, Alisol A 24-acetate and Alisol B 23-acetate could be expected as main compounds. Taken together, A. orientale might be an effective candidate agent for the treatment of NAFLD and its comorbidities, although further assessment of its standardization, safety test, and clinical trials is consistently required.
C1 [Choi, Eunsol] Kyung Hee Univ, Dept Clin Korean Med, Grad Sch, 26 Kyungheedae Ro, Seoul 02447, South Korea.
   [Jang, Eungyeong; Lee, Jang-Hoon] Kyung Hee Univ, Coll Korean Med, Dept Internal Med, 26 Kyungheedae Ro, Seoul 02447, South Korea.
   [Jang, Eungyeong] Kyung Hee Univ, Korean Med Hosp, Dept Internal Med, 23 Kyungheedae Ro, Seoul 02447, South Korea.
C3 Kyung Hee University; Kyung Hee University; Kyung Hee University
RP Lee, JH (corresponding author), Kyung Hee Univ, Coll Korean Med, Dept Internal Med, 26 Kyungheedae Ro, Seoul 02447, South Korea.
EM komclive@khmc.or.kr
RI Jang, Eungyeong/GMX-1947-2022
OI Lee, Jang-Hoon/0000-0002-4881-7357
FU Korea Health Technology R&D Project through the Korea Health Industry
   Development Institute (KHIDI) - Ministry of Health & Welfare, Republic
   of Korea [HI14C0955]
FX This research was supported by a Grant (HI14C0955) from the Korea Health
   Technology R&D Project through the Korea Health Industry Development
   Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic
   of Korea.
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NR 81
TC 26
Z9 28
U1 1
U2 16
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1741-427X
EI 1741-4288
J9 EVID-BASED COMPL ALT
JI Evid.-based Complement Altern. Med.
PY 2019
VL 2019
AR 2943162
DI 10.1155/2019/2943162
PG 15
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA ID8DE
UT WOS:000471912200001
PM 31275407
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Yerlikaya, A
   Dagel, T
   King, C
   Kuwabara, M
   Lanaspa, MA
   Andres-Hernando, A
   Covic, A
   Manitius, J
   Sag, AA
   Kanbay, M
AF Yerlikaya, Aslihan
   Dagel, Tuncay
   King, Christopher
   Kuwabara, Masanari
   Lanaspa, Miguel A.
   Andres-Hernando, Ana
   Covic, Adrian
   Manitius, Jacek
   Sag, Alan A.
   Kanbay, Mehmet
TI Dietary and commercialized fructose: Sweet or sour?
SO INTERNATIONAL UROLOGY AND NEPHROLOGY
LA English
DT Review
DE Fructose; Cardiovascular disease; Kidney disease; Obesity; Hypertension
ID SERUM URIC-ACID; CHRONIC KIDNEY-DISEASE; METABOLIC SYNDROME; CORN SYRUP;
   HYPERTENSIVE PATIENTS; GUT MICROBIOTA; BLOOD-PRESSURE; RENAL-FUNCTION;
   FATTY-LIVER; PPAR-ALPHA
AB Metabolic syndrome and diabetes are main health problems of modern life in the twenty-first century. Alarming ratios of global prevalence lead to conduct more and more researches about etiological factors and pathogenesis. Disease mechanism is elementary for advancing more efficient and practicable treatment methods. Concurrent increase in both fructose consumption with Western diet and metabolic syndrome has revealed fructose hypothesis that suggests fructose as one of etiological factor of metabolic syndrome (insulin resistance, central obesity, hypertension, etc.). Recent studies have increasingly lightened the unknowns about role of fructose on pathogenesis. This review discusses fructose hypothesis by exploring current studies and their results in wide perspective. Potential mechanisms covering low-grade inflammation or de novo lipogenesis, etc., in the development of insulin resistance and obesity are explained. Clinical trials have revealed connection of fructose-induced hyperuricemia with insulin resistance and chronic inflammatory state leading to hepatosteatosis or obesity. Further, novel hypothesizes suggesting role of fructose-induced modifications in epigenetics, gut microbiota and oxidative stress on disease pathogenesis are reviewed based on recent clinical trials. More innovative theories including fructose-induced malignancy; decreased satiety feeling, and unfavorable bone health are argued covering fructose-induced neurotransmitter changes in central nervous system, more aggressive malignancy phenotype and impaired calcium absorption.
C1 [Yerlikaya, Aslihan; Kanbay, Mehmet] Koc Univ, Sch Med, TR-34450 Istanbul, Turkey.
   [Dagel, Tuncay; Kanbay, Mehmet] Koc Univ Hosp, Div Nephrol, Dept Med, Istanbul, Turkey.
   [King, Christopher; Kuwabara, Masanari; Lanaspa, Miguel A.; Andres-Hernando, Ana] Univ Colorado, Div Renal Dis & Hypertens, Denver, CO 80202 USA.
   [Covic, Adrian] CI PARHON Univ Hosp, Dialysis & Renal Transplant Ctr, Nephrol Clin, Iasi, Romania.
   [Covic, Adrian] Grigore T Popa Univ Med Iasi, Iasi, Romania.
   [Manitius, Jacek] Nicolaus Copernicus Univ, Dept Hypertens & Internal Med, Bydgoszcz, Poland.
   [Sag, Alan A.] Koc Univ, Sch Med, Div Intervent Radiol, Dept Radiol, Istanbul, Turkey.
C3 Koc University; Koc University; University of Colorado System;
   University of Colorado Denver; National Institute of Endocrinology C.I.
   Parhon; Grigore T Popa University of Medicine & Pharmacy; Nicolaus
   Copernicus University; Koc University
RP Kanbay, M (corresponding author), Koc Univ, Sch Med, TR-34450 Istanbul, Turkey.; Kanbay, M (corresponding author), Koc Univ Hosp, Div Nephrol, Dept Med, Istanbul, Turkey.
EM mkanbay@ku.edu.tr
RI Covic, Adrian/G-5017-2016; 1, 1/L-6277-2019; Lanaspa,
   Miguel/AAO-4971-2020; Kuwabara, Masanari/O-9844-2017
OI Sag, Alan Alper/0000-0002-3106-0458; Kuwabara,
   Masanari/0000-0002-6601-4347; Andres-Hernando, Ana/0000-0002-0676-0188;
   Yerlikaya, Aslihan/0000-0001-6186-1646; Kanbay,
   Mehmet/0000-0002-1297-0675
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NR 61
TC 25
Z9 28
U1 0
U2 20
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0301-1623
EI 1573-2584
J9 INT UROL NEPHROL
JI Int. Urol. Nephrol.
PD SEP
PY 2017
VL 49
IS 9
BP 1611
EP 1620
DI 10.1007/s11255-017-1544-8
PG 10
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA FD7XO
UT WOS:000407739600013
PM 28210913
DA 2025-06-11
ER

PT J
AU Gharaei, FK
   Lakzaei, H
   Niazi, AA
   Jahantigh, M
   Shahraki, MR
   Safari, T
AF Gharaei, Fatemeh Kourkinejad
   Lakzaei, Halimeh
   Niazi, Abbass Ali
   Jahantigh, Mehdi
   Shahraki, Mohammad Reza
   Safari, Tahereh
TI The protective effects of eugenol on metabolic-syndrome, renal damages
SO JOURNAL OF RENAL INJURY PREVENTION
LA English
DT Article
DE Eugenol; Metabolic syndrome; Kidney injury
ID OXIDATIVE STRESS; INSULIN-RESISTANCE; FRUCTOSE; DISEASE
AB Introduction: Metabolic syndrome consists of a group of abnormities which is involved with chronic kidney disease and nephropathy. Eugenol is an important phenolic component, which is present in many plants' essential oils such as cloves oil with antioxidant effects.
   Objectives: Our study planned to demonstrate eugenol's effects over nephrotoxicity derived from metabolic syndrome.
   Materials and Methods: Thirty-five male Wistar rats were picked accidentally and then divided into five groups including 1) tap water; 2) water with fructose10%; 3) water with fructose + sweet almond oil and administered intraperitoneally; 4) water with fructose+ eugenol 50 mg/kg/d and administered intraperitoneally; 5) water with fructose+ eugenol 100 mg/kg/d administered intraperitoneally. This regime lasted for 60 days, and at the beginning of day 31st, injections started for 30 days. Assessment of serum, urine and renal parameters (in homogenized kidney tissue) were conducted in the last step.
   Results: The results argued that the induction of metabolic syndrome following renal injury has significantly increased serum blood urea nitrogen (BUN) and creatinine (Cr) levels in the fructose group. Consumption of eugenol resulted in a significant reduction in the level of these two biochemical factors (P < 0.05). The renal level of malondialdehyde (MDA) increased in the fructose group while treatment with a dose of 50 eugenol decreasing its level (P < 0.05). Proteinuria and kidney tissue damage score (KTDS) increased in the fructose group compared with the tap water group (P < 0.001). It is noteworthy that treatment with eugenol did not affect the level of proteinuria and KTDS with any of the used doses.
   Conclusion: Our results indicated the improvement of renal functioning and decrease in lipid peroxidation, although eugenol doses used in this study did not reduce proteinuria and KTDS.
C1 [Gharaei, Fatemeh Kourkinejad] Zahedan Univ Med Sci, Fac Med, Zahedan, Iran.
   [Gharaei, Fatemeh Kourkinejad] Zahedan Univ Med Sci, Student Res Comm, Zahedan, Iran.
   [Lakzaei, Halimeh; Niazi, Abbass Ali; Jahantigh, Mehdi; Shahraki, Mohammad Reza; Safari, Tahereh] Zahedan Univ Med Sci, Sch Med, Dept Physiol, Zahedan, Iran.
   [Safari, Tahereh] Zahedan Univ Med Sci, Pharmacol Res Ctr, Zahedan, Iran.
C3 Zahedan University of Medical Sciences; Zahedan University of Medical
   Sciences; Zahedan University of Medical Sciences; Zahedan University of
   Medical Sciences
RP Safari, T (corresponding author), Zahedan Univ Med Sci, Sch Med, Dept Physiol, Zahedan, Iran.; Safari, T (corresponding author), Zahedan Univ Med Sci, Pharmacol Res Ctr, Zahedan, Iran.
EM tahereh_safari@yahoo.com
RI shahraki, Mohammad/Q-7977-2017; Gharaei, Fatemeh/ABE-4547-2020; Safari,
   Tahereh/Z-5453-2019
OI Kourkinejad_Gharaei, Fatemeh/0000-0002-1795-5466
FU Zahedan University of Medical Sciences [8997]
FX The research was corroborated by Zahedan University of Medical Sciences
   (Grant #8997).
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NR 22
TC 1
Z9 1
U1 0
U2 2
PU NIKAN RESEARCH INST
PI ISFAHAN
PA NO 8, 23 LN, FARABI NORTH ST, FREIBURG AVE, PO BOX 81655-963, ISFAHAN,
   81687-95341, IRAN
SN 2345-2781
J9 J RENAL INJ PREV
JI J. Renal Inj. Prev.
PY 2022
VL 11
IS 1
AR e04
DI 10.34172/jrip.2022.04
PG 5
WC Urology & Nephrology
WE Emerging Sources Citation Index (ESCI)
SC Urology & Nephrology
GA WF3PY
UT WOS:000706221700004
OA gold
DA 2025-06-11
ER

PT J
AU Spinedi, E
   Cardinali, DP
AF Spinedi, Eduardo
   Cardinali, Daniel P.
TI The Polycystic Ovary Syndrome and the Metabolic Syndrome: A Possible
   Chronobiotic-Cytoprotective Adjuvant Therapy
SO INTERNATIONAL JOURNAL OF ENDOCRINOLOGY
LA English
DT Review
ID ADIPOSE-TISSUE; MELATONIN TREATMENT; INSULIN-RESISTANCE;
   GLUCOSE-TOLERANCE; OXIDATIVE STRESS; 6-SULFATOXYMELATONIN EXCRETION;
   NONALCOHOLIC STEATOHEPATITIS; DIAGNOSTIC-CRITERIA; GENE POLYMORPHISMS;
   ANDROGEN RECEPTORS
AB Polycystic ovary syndrome is a highly frequent reproductive-endocrine disorder affecting up to 8-10% of women worldwide at reproductive age. Although its etiology is not fully understood, evidence suggests that insulin resistance, with or without compensatory hyperinsulinemia, and hyperandrogenism are very common features of the polycystic ovary syndrome phenotype. Dysfunctional white adipose tissue has been identified as a major contributing factor for insulin resistance in polycystic ovary syndrome. Environmental (e.g., chronodisruption) and genetic/epigenetic factors may also play relevant roles in syndrome development. Overweight and/or obesity are very common in women with polycystic ovary syndrome, thus suggesting that some polycystic ovary syndrome and metabolic syndrome female phenotypes share common characteristics. Sleep disturbances have been reported to double in women with PCOS and obstructive sleep apnea is a common feature in polycystic ovary syndrome patients. Maturation of the luteinizing hormone-releasing hormone secretion pattern in girls in puberty is closely related to changes in the sleep-wake cycle and could have relevance in the pathogenesis of polycystic ovary syndrome. This review article focuses on two main issues in the polycystic ovary syndrome-metabolic syndrome phenotype development: (a) the impact of androgen excess on white adipose tissue function and (b) the possible efficacy of adjuvant melatonin therapy to improve the chronobiologic profile in polycystic ovary syndrome-metabolic syndrome individuals. Genetic variants in melatonin receptor have been linked to increased risk of developing polycystic ovary syndrome, to impairments in insulin secretion, and to increased fasting glucose levels. Melatonin therapy may protect against several metabolic syndrome comorbidities in polycystic ovary syndrome and could be applied from the initial phases of patients' treatment.
C1 [Spinedi, Eduardo] UNLP CONICET FCM, La Plata Med Sch, CEAS CICPBA, Ctr Expt & Appl Endocrinol,CENEXA, La Plata, Buenos Aires, Argentina.
   [Cardinali, Daniel P.] Pontificia Univ Catolica Argentina, BIOMED UCA CONICET, Buenos Aires, DF, Argentina.
   [Cardinali, Daniel P.] Pontificia Univ Catolica Argentina, Dept Teaching & Res, Fac Med Sci, Buenos Aires, DF, Argentina.
C3 Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET);
   Pontificia Universidad Catolica Argentina; Pontificia Universidad
   Catolica Argentina
RP Spinedi, E (corresponding author), UNLP CONICET FCM, La Plata Med Sch, CEAS CICPBA, Ctr Expt & Appl Endocrinol,CENEXA, La Plata, Buenos Aires, Argentina.
EM spinedi@cenexa.org
FU National Research Council of Argentina (CONICET); PICT from the ANPCyT,
   Argentina [2007-01045, 2012-0984]; Swiss Foundation for Research on
   Endocrinology, Diabetes and Metabolism [FPREDM052015]
FX The authors wish to thank Susan H. Rogers for editing and correcting
   this manuscript. The authors are Research Career Awardees from the
   National Research Council of Argentina (CONICET). Studies carried out by
   authors were supported by grant PICT (2007-01045 and 2012-0984) from the
   ANPCyT, Argentina and, the Swiss Foundation for Research on
   Endocrinology, Diabetes and Metabolism (FPREDM052015).
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NR 108
TC 25
Z9 25
U1 0
U2 31
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1687-8337
EI 1687-8345
J9 INT J ENDOCRINOL
JI Int. J. Endocrinol.
PY 2018
VL 2018
AR 1349868
DI 10.1155/2018/1349868
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA GP5LR
UT WOS:000440915400001
PM 30147722
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Hutcheson, R
   Terry, R
   Chaplin, J
   Smith, E
   Musiyenko, A
   Russell, JC
   Lincoln, T
   Rocic, P
AF Hutcheson, Rebecca
   Terry, Russell
   Chaplin, Jennifer
   Smith, Erika
   Musiyenko, Alla
   Russell, James C.
   Lincoln, Thomas
   Rocic, Petra
TI MicroRNA-145 Restores Contractile Vascular Smooth Muscle Phenotype and
   Coronary Collateral Growth in the Metabolic Syndrome
SO ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
LA English
DT Article
DE collateral circulation; metabolic syndrome; microRNA; vascular smooth
   muscle phenotype
ID LA-CP RAT; CELL-PROLIFERATION; LUNG ADENOCARCINOMA; VESSEL DEVELOPMENT;
   ARTERY-DISEASE; MIR-145; EXPRESSION; INSULIN; CIRCULATION; STRESS
AB Objective-Transient, repetitive occlusion stimulates coronary collateral growth (CCG) in normal animals. Vascular smooth muscle cells (VSMCs) switch to synthetic phenotype early in CCG, then return to contractile phenotype. CCG is impaired in the metabolic syndrome. We determined whether impaired CCG was attributable to aberrant VSMC phenotypic modulation by miR-145-mediated mechanisms, and whether restoration of physiological miR-145 levels in metabolic syndrome (JCR rat) improved CCG.
   Approach and Results-CCG was stimulated by transient, repetitive left anterior descending artery occlusion and evaluated after 9 days by coronary blood flow measurements (microspheres). miR-145 was delivered to JCR VSMCs via adenoviral vector (miR-145-Adv). In JCR rats, miR-145 was decreased late in CCG (approximate to 2-fold day 6; approximate to 4-fold day 9 versus SD), which correlated with decreased expression of smooth muscle-specific contractile proteins (approximate to 5-fold day 6; approximate to 10-fold day 9 versus SD), indicative of VSMCs' failure to return to the contractile phenotype late in CCG. miR-145 expression in JCR rats (miR-145-Adv) on days 6 to 9 of CCG completely restored VSMCs contractile phenotype and CCG (collateral/normal zone flow ratio was 0.93 +/- 0.09 JCR+miR-145-Adv versus 0.12 +/- 0.02 JCR versus 0.87 +/- 0.02 SD).
   Conclusions-Restoration of VSMC contractile phenotype through miR-145 delivery is a highly promising intervention for restoration of CCG in the metabolic syndrome. (Arterioscler Thromb Vasc Biol. 2013; 33: 727-736.)
C1 [Hutcheson, Rebecca; Terry, Russell; Chaplin, Jennifer; Smith, Erika; Musiyenko, Alla; Rocic, Petra] Univ S Alabama, Coll Med, Dept Biochem & Mol Biol, Mobile, AL 36688 USA.
   [Lincoln, Thomas] Univ S Alabama, Coll Med, Dept Physiol, Mobile, AL 36688 USA.
   [Russell, James C.] Univ Alberta, Alberta Inst Human Nutr, Metab & Cardiovasc Dis Lab, Edmonton, AB, Canada.
C3 University of South Alabama; University of South Alabama; University of
   Alberta
RP Rocic, P (corresponding author), Univ S Alabama, Coll Med, Dept Biochem & Mol Biol, 307 N Univ Blvd, Mobile, AL 36688 USA.
EM procic@usouthal.edu
RI Terry, Russell/X-8364-2019
OI Terry, Russell/0000-0002-3659-060X; Rocic, Petra/0000-0002-5781-3075
FU American Heart Association [11PRE7690011]; National Institutes of Health
   [R01HL093052]; American Heart Association (AHA) [11PRE7690011] Funding
   Source: American Heart Association (AHA)
FX This study was supported by grants from the American Heart Association
   11PRE7690011 to R. Hutcheson and National Institutes of Health
   R01HL093052 to P. Rocic.
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PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 1079-5642
J9 ARTERIOSCL THROM VAS
JI Arterioscler. Thromb. Vasc. Biol.
PD APR
PY 2013
VL 33
IS 4
BP 727
EP U193
DI 10.1161/ATVBAHA.112.301116
PG 21
WC Hematology; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Hematology; Cardiovascular System & Cardiology
GA 105ZE
UT WOS:000316110400013
PM 23393394
OA Bronze, Green Accepted
DA 2025-06-11
ER

PT J
AU Raczkiewicz, D
   Owoc, A
   Wierzbinska-Stepniak, A
   Bojar, I
AF Raczkiewicz, Dorota
   Owoc, Alfred
   Wierzbinska-Stepniak, Anna
   Bojar, Iwona
TI Metabolic syndrome in peri- and postmenopausal women performing
   intellectual work
SO ANNALS OF AGRICULTURAL AND ENVIRONMENTAL MEDICINE
LA English
DT Article
DE menopause; metabolic syndrome; intellectual work
AB Introduction. Metabolic Syndrome is a set of interrelated risk factors for the emergence and progression of cardiovascular disease and diabetes, such as central obesity (abdominal), elevated blood pressure and disorders of carbohydrate and lipid metabolism.
   Peri- and postmenopausal women are particularly at risk for developing MS by the aging and loss of the protective effect of estrogen on the body, additionally by intellectual work associated with a sedentary lifestyle and job stress.
   Objective. The aim of the study was to analyze the frequency of MS and its criteria in perimenopausal and postmenopausal women performing intellectual work, as well as selected factors on which the metabolic syndrome depends.
   Materials and method. The study group consist of 300 women aged 44-66 working intellectually. Research methods used: metabolic syndrome's criteria, Greene Climacteric Scale, body fat accumulation, medical interview. Statistical methods used: logistic regression analysis, analysis of variance, chi(2) test of stochastic independence.
   Results. The MS was diagnosed in about 1/4 of the women in perimenopausal and postmenopausal period working intellectually; in most of them, abdominal obesity (3/4), in more than a half hypertension, in every sixth hypertriglyceridaemia, in every seventh hyperglycaemia and in every tenth low HDL-C. Prevalence of MS and its criteria was correlated with BMI, body fat accumulation and parity. Prevalence of arterial hypertension was associated with the severity of menopausal symptoms and lack of physical activity.
   Conclusions. Prevalence of MS and some of its criteria depended on BMI, body fat accumulation, parity, severity of menopausal symptoms and lack of physical activity, whereas it did not depend on: age between 44-66, educational level, marital status or HRT taking.
C1 [Raczkiewicz, Dorota] Warsaw Sch Econ, Inst Stat & Demog, Niepodleglosci 162, PL-02554 Warsaw, Poland.
   [Owoc, Alfred] Inst Rural Hlth, Ctr Publ Hlth & Hlth Promot, Lublin, Poland.
   [Wierzbinska-Stepniak, Anna; Bojar, Iwona] Inst Rural Hlth, Dept Woman Hlth, Lublin, Poland.
C3 Warsaw School of Economics; Institute of Rural Health in Lublin, Poland;
   Institute of Rural Health in Lublin, Poland
RP Raczkiewicz, D (corresponding author), Warsaw Sch Econ, Inst Stat & Demog, Niepodleglosci 162, PL-02554 Warsaw, Poland.
EM dbartos@sgh.waw.pl
RI Raczkiewicz, Dorota/HKV-8966-2023; Bojar, Iwona/S-6029-2018
OI Bojar, Iwona/0000-0002-3171-225X; Raczkiewicz,
   Dorota/0000-0003-3517-6711
FU Ministry of Science and Higher Education/National Center for Research
   and Development
FX This work was conducted in the Institute of Rural Health, Lublin,
   Poland, as a part of the project "Mental and Physical Health of Women in
   the Perimenopausal and Postmenopausal Period in Terms of Preserving
   their Ability to Work". The study was conducted within the framework of
   the third stage of the multiannual program "Improving the Operational
   Safety and Working Conditions", financed in the years 20142016 by the
   Ministry of Science and Higher Education/National Center for Research
   and Development. The program coordinator was the Central Institute for
   Labour Protection - National Research Institute.
CR Cybulska B, WYTYCZNE RADY REDAKC
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NR 18
TC 6
Z9 8
U1 0
U2 7
PU INST AGRICULTURAL MEDICINE
PI LUBLIN
PA JACZEWSKIEGO 2, PO BOX 185, 20-950 LUBLIN, POLAND
SN 1232-1966
EI 1898-2263
J9 ANN AGR ENV MED
JI Ann. Agr. Env. Med.
PY 2018
VL 25
IS 4
BP 610
EP 615
DI 10.26444/aaem/74451
PG 6
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA HF4HG
UT WOS:000454193500007
PM 30586981
OA gold
DA 2025-06-11
ER

PT J
AU Takai, S
   Jin, D
   Miyazaki, M
AF Takai, S.
   Jin, D.
   Miyazaki, M.
TI Chymase as an Important Target for Preventing Complications of Metabolic
   Syndrome
SO CURRENT MEDICINAL CHEMISTRY
LA English
DT Review
DE Angiotensin II; chymase; matrix metalloproteinase-9; metabolic syndrome;
   transforming growth factor-beta
ID ANGIOTENSIN-CONVERTING-ENZYME; ABDOMINAL AORTIC-ANEURYSM; GLYCATION
   END-PRODUCTS; HIGH-CHOLESTEROL DIET; SPONTANEOUSLY HYPERTENSIVE-RATS;
   GROWTH-FACTOR EXPRESSION; CHRONIC LIVER-DISEASES; MAST-CELLS;
   NONALCOHOLIC STEATOHEPATITIS; MYOCARDIAL-INFARCTION
AB Chymase plays a crucial role in angiotensin II formation in various tissues. Angiotensin II induces gene expressions of transforming growth factor (TGF)-beta and matrix metalloproteinase (MMP)-9, and chymase also converts precursors of TGF-beta and MMP-9 to their active forms. All of angiotensin II, TGF-beta and MMP-9 are considered to be closely involved in the development and progression of metabolic syndrome and its complications. In a diabetic animal model, chymase induced pancreatic disorganization via attack of oxidative stress induced by augmentation of chymase-forming angiotensin II. In atherosclerotic lesions in patients, accumulation of chymase-positive cells was observed, and chymase inhibition prevented the development of atherosclerosis in an animal model. In Apo E-deficient mice, chymase inhibition prevents the development of angiotensin II-induced abdominal aneurysmal aorta (AAA). In this model, the AAA development on an increase in MMP-9 activities induced by angiotensin II, but the inhibition of MMP-9 activation by chymase inhibitor resulted in attenuation of the AAA development. Cardiac dysfunction after myocardial infarction was also attenuated by chymase inhibition. Steatosis and fiblosis in liver were strongly prevented by chymase inhibition in an animal model with nonalcoholic steatohepatitis which is involved in metabolic syndrome. Therefore, chymase inhibition may be useful for attenuating MMP-9 and TGF-beta levels, in addition to reducing angiotensin II formation, and this function may provide powerful preventions of organ damages. In this review, we propose the significance of chymase as a target to prevent complications of metabolic syndrome.
C1 [Takai, S.; Jin, D.; Miyazaki, M.] Osaka Med Coll, Dept Pharmacol, Takatsuki, Osaka 5698686, Japan.
C3 Osaka Medical & Pharmaceutical University
RP Takai, S (corresponding author), Osaka Med Coll, Dept Pharmacol, 2-7 Daigaku Machi, Takatsuki, Osaka 5698686, Japan.
EM pha010@art.osaka-med.ac.jp
RI Takai, Shinji/NES-5695-2025
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NR 73
TC 8
Z9 9
U1 0
U2 3
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y26, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 0929-8673
J9 CURR MED CHEM
JI Curr. Med. Chem.
PD SEP
PY 2010
VL 17
IS 28
BP 3223
EP 3229
DI 10.2174/092986710792232003
PG 7
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Pharmacology &
   Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
GA 653OY
UT WOS:000282104000005
PM 20666722
DA 2025-06-11
ER

PT J
AU Fujita, T
AF Fujita, Toshiro
TI Mineralocorticoid Receptors, Salt-Sensitive Hypertension, and Metabolic
   Syndrome
SO HYPERTENSION
LA English
DT Article
DE salt; aldosterone; mineralocorticoid receptor; Rac1; obesity
ID VENTRICULAR DIASTOLIC DYSFUNCTION; OBESITY-INDUCED HYPERTENSION;
   SMOOTH-MUSCLE-CELLS; BLOOD-PRESSURE; OXIDATIVE STRESS; KIDNEY-DISEASE;
   ANGIOTENSIN-II; SODIUM SENSITIVITY; INSULIN-RESISTANCE; EPITHELIAL-CELLS
AB Obese persons with metabolic syndrome often have associated with salt-sensitive hypertension, microalbuminuria, and cardiac dysfunction, and the plasma aldosterone level in one-third of metabolic syndrome patients is clearly elevated. Hyperaldosteronism, which may be caused at least partially by certain adipocyte-derived factors, contributes to the development of proteinuria in obese hypertensive rats, and salt loading aggravates the proteinuria and induces cardiac diastolic dysfunction because of inadequate suppression of plasma aldosterone level. However, mineralocorticoid receptor (MR) antagonists prevent salt-induced renal and cardiac damage, suggesting that aldosterone excess and a high-salt diet exert an unfavorable synergistic action on the kidney and heart. In Dahl salt-sensitive rats, however, despite appropriate suppression of plasma aldosterone with a high-salt diet, salt loading paradoxically activated renal MR signaling, and the renal injury was markedly prevented by MR antagonists. Accordingly, we discovered an alternative pathway of MR activation in which Rac1, a small GTP-binding protein, activates MRs. Salt loading activates renal Rac1 in Dahl salt-sensitive rats, and Rac1 in turn induces MR activation, which results in renal injury, and the renal injury has been found to be prevented by Rac1 inhibitors. Moreover, several metabolic syndrome-related factors induce Rac1 activation, and one of them, hyperglycemia, activates MRs via Rac1 activation. Consistent with this, Rac1 inhibitors attenuated the proteinuria and renal injury in obese hypertensive animals. Thus, both salt and obesity activate Rac1 and cause MR activation. Abnormal activation of the aldosterone/MR pathway plays a key role in the development of salt-sensitive hypertension and renal injury in metabolic syndrome. (Hypertension. 2010;55:813-818.)
C1 Univ Tokyo, Dept Nephrol & Endocrinol, Sch Med, Bunkyo Ku, Tokyo 1138655, Japan.
C3 University of Tokyo
RP Fujita, T (corresponding author), Univ Tokyo, Dept Nephrol & Endocrinol, Sch Med, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1138655, Japan.
EM fujita-dis@h.u-tokyo.ac.jp
OI Fujita, Toshiro/0000-0001-9141-7060
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NR 59
TC 91
Z9 97
U1 1
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0194-911X
EI 1524-4563
J9 HYPERTENSION
JI Hypertension
PD APR
PY 2010
VL 55
IS 4
BP 813
EP 818
DI 10.1161/HYPERTENSIONAHA.109.149062
PG 6
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 570TS
UT WOS:000275701600001
PM 20176994
OA Bronze
DA 2025-06-11
ER

PT J
AU Poruba, M
   Anzenbacher, P
   Racova, Z
   Oliyarnyk, O
   Hüttl, M
   Malinska, H
   Markova, I
   Gurska, S
   Kazdova, L
   Vecera, R
AF Poruba, M.
   Anzenbacher, P.
   Racova, Z.
   Oliyarnyk, O.
   Huttl, M.
   Malinska, H.
   Markova, I
   Gurska, S.
   Kazdova, L.
   Vecera, R.
TI The Effect of Combined Diet Containing n-3 Polyunsaturated Fatty Acids
   and Silymarin on Metabolic Syndrome in Rats
SO PHYSIOLOGICAL RESEARCH
LA English
DT Article
DE Polyunsaturated fatty acids; Silymarin; Metabolic syndrome; ABCG5/8
ID CARDIOVASCULAR-DISEASE; INSULIN-RESISTANCE; NONALCOHOLIC
   STEATOHEPATITIS; EICOSAPENTAENOIC ACID; DOCOSAHEXAENOIC ACID;
   CYTOCHROME-P450 2E1; EXPERIMENTAL-MODEL; OXIDATIVE STRESS;
   ATHEROSCLEROSIS; SUPPLEMENTATION
AB The risk of development of metabolic syndrome can be increased by hypertriglyceridemia. A search for effective therapy is a subject of considerable attention. Therefore, our hypothesis is that the fish oil (containing polyunsaturated fatty acids; n-3 PUFA) in a combination with silymarin can more effectively protect against hypertriglyceridemia-induced metabolic disturbances. The study was conducted using a unique non-obese strain of rats with hereditary hypertriglyceridemia an accepted model of metabolic syndrome. Adult male rats were treated with n-3 PUFA (300 mg/kg/day) without or with 1 % micronized silymarin in a diet for 4 weeks. The treatment with the diet containing n-3 PUFA and silymarin significantly reduced concentrations of serum triglycerides (-45 %), total cholesterol (-18 %), non-esterified fatty acids (-33 %), and ectopic lipid accumulation in skeletal muscle (-35 %) compared to controls. In addition, an increase in Abcg5 and Abcg8 mRNA expression (as genes affecting lipid homeostasis) as well as in protein content of ABCG5 (+78 %) and ABCG8 (+232 %) transporters have been determined in the liver of treated rats. Our findings suggest that this combined diet could be used in the prevention of hypertriglyceridemia-induced metabolic disorders.
C1 [Poruba, M.; Anzenbacher, P.; Racova, Z.; Vecera, R.] Palacky Univ Olomouc, Fac Med & Dent, Dept Pharmacol, Hnevotinska 3, Olomouc 77900, Czech Republic.
   [Oliyarnyk, O.; Huttl, M.; Malinska, H.; Markova, I; Kazdova, L.] Inst Clin & Expt Med, Ctr Expt Med, Prague, Czech Republic.
   [Gurska, S.] Palacky Univ Olomouc, Fac Med & Dent, Inst Mol & Translat Med, Olomouc, Czech Republic.
C3 Palacky University Olomouc; Institute for Clinical & Experimental
   Medicine (IKEM); Palacky University Olomouc
RP Poruba, M (corresponding author), Palacky Univ Olomouc, Fac Med & Dent, Dept Pharmacol, Hnevotinska 3, Olomouc 77900, Czech Republic.
EM zuzu.matuskova@seznam.cz
OI Markova, Irena/0000-0002-4331-7636; Poruba, Martin/0000-0003-1252-4971;
   Racova, Zuzana/0000-0001-9478-9513
FU Czech Science Foundation GACR [17-08888S]; infrastructural project NPU I
   [LO1304];  [IGA_LF_2019_011]
FX This study was supported by the Czech Science Foundation GACR
   (17-08888S) and the grant IGA_LF_2019_011 as well as by the
   infrastructural project NPU I (LO1304).
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NR 39
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Z9 7
U1 0
U2 13
PU ACAD SCIENCES CZECH REPUBLIC, INST PHYSIOLOGY
PI PRAGUE 4
PA VIDENSKA 1083, PRAGUE 4 142 20, CZECH REPUBLIC
SN 0862-8408
EI 1802-9973
J9 PHYSIOL RES
JI Physiol. Res.
PY 2019
VL 68
SU 1
BP S39
EP S50
DI 10.33549/physiolres.934322
PG 12
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA JQ6XF
UT WOS:000499085100005
PM 31755289
OA gold
DA 2025-06-11
ER

PT J
AU Zhang, XM
   Tian, FF
   Kawai, H
   Kurata, T
   Deguchi, S
   Deguchi, K
   Shang, JW
   Liu, N
   Liu, WT
   Ikeda, Y
   Matsuura, T
   Kamiya, T
   Abe, K
AF Zhang, Xuemei
   Tian, Fengfeng
   Kawai, Hiromi
   Kurata, Tomoko
   Deguchi, Shoko
   Deguchi, Kentaro
   Shang, Jingwei
   Liu, Ning
   Liu, Wentao
   Ikeda, Yoshio
   Matsuura, Tohru
   Kamiya, Tatsushi
   Abe, Koji
TI Anti-Inflammatory Effect of Amlodipine Plus Atorvastatin Treatment on
   Carotid Atherosclerosis in Zucker Metabolic Syndrome Rats
SO TRANSLATIONAL STROKE RESEARCH
LA English
DT Article
DE Amlodipine; Atorvastatin; Common carotid artery; Zucker metabolic
   syndrome rat
ID VASCULAR CALCIFICATION; CARDIOVASCULAR-DISEASE; CEREBRAL INFARCTION;
   OXIDATIVE STRESS; ISCHEMIC-STROKE; MECHANISMS; INHIBITION; EXPRESSION;
   MORTALITY; PRESSURE
AB To investigate the effects of amlodipine in combination with atorvastatin on carotid atherosclerotic changes in metabolic syndrome, 8-week-old Zucker fatty rats were treated with vehicle, amlodipine, atorvastatin, or amlodipine in combination with atorvastatin for 28 days. Histological studies of common carotid arteries showed that lipid deposition determined by Sudan III staining was significantly reduced in rats treated with amlodipine or atorvastatin alone and was further reduced by amlodipine in combination with atorvastatin. Immunohistochemical studies of the pro-inflammatory cytokine tumor necrosis factor (TNF)-alpha, the arterial calcification initiator bone morphogenetic protein (BMP) 2, the angiogenic factor Notch1, and the smooth muscle cell marker alpha-smooth muscle actin (SMA) showed that the high expression of all four protein in vehicle-treated rats was greatly decreased by amlodipine, atorvastatin, or amlodipine in combination with atorvastatin, in ascending order. Double immunostaining showed marked colocalization of TNF-alpha with bone morphogenetic protein 2 and Notch1 with alpha-SMA in the vehicle group, which was greatly reduced by amlodipine plus atorvastatin. These data suggest that combination therapy may be more effective in preventing atherosclerotic processes and subsequent carotid vascular events than administrating amlodipine or atorvastatin alone in metabolic syndrome.
C1 [Zhang, Xuemei; Tian, Fengfeng; Kawai, Hiromi; Kurata, Tomoko; Deguchi, Shoko; Deguchi, Kentaro; Shang, Jingwei; Liu, Ning; Liu, Wentao; Ikeda, Yoshio; Matsuura, Tohru; Kamiya, Tatsushi; Abe, Koji] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Neurol, Okayama 7008558, Japan.
C3 Okayama University
RP Abe, K (corresponding author), Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Neurol, 2-5-1 Shikatacho, Okayama 7008558, Japan.
EM gmd20201@s.okayama-u.ac.jp
RI Thumm, Michael/A-8033-2015; Liu, Ning/B-2875-2010
FU Ministry of Education, Science, Culture and Sports of Japan; Research
   Committee of CNS Degenerative Diseases; Ministry of Health, Labour and
   Welfare of Japan;  [21390267]
FX This study was supported in part by Grant-in-aid for Scientific Research
   (B) 21390267 and the Ministry of Education, Science, Culture and Sports
   of Japan, by Grants-in-aid from the Research Committee of CNS
   Degenerative Diseases (Nakano I), and by grants (Itoyama Y, Imai T,
   Sobue G, and Mizusawa H) from the Ministry of Health, Labour and Welfare
   of Japan.
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NR 31
TC 4
Z9 4
U1 0
U2 9
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1868-4483
J9 TRANSL STROKE RES
JI Transl. Stroke Res.
PD DEC
PY 2012
VL 3
IS 4
BP 435
EP 441
DI 10.1007/s12975-012-0198-1
PG 7
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 041MX
UT WOS:000311407000004
PM 24323832
DA 2025-06-11
ER

PT J
AU Fernando, IPS
   Ryu, B
   Ahn, G
   Yeo, IK
   Jeon, YJ
AF Fernando, Ilekuttige Priyan Shanura
   Ryu, BoMi
   Ahn, Ginnae
   Yeo, In-Kyu
   Jeon, You-Jin
TI Therapeutic potential of algal natural products against metabolic
   syndrome: A review of recent developments
SO TRENDS IN FOOD SCIENCE & TECHNOLOGY
LA English
DT Review
DE Marine algae; Metabolic syndrome; Polyphenols; Diabetes; Obesity
ID ALLEVIATES POSTPRANDIAL HYPERGLYCEMIA; TYROSINE-PHOSPHATASE 1B; EDIBLE
   BROWN-ALGAE; ACTIVATED PROTEIN-KINASE; ACE INHIBITORY PEPTIDE;
   ECKLONIA-CAVA; ALPHA-GLUCOSIDASE; IN-VITRO; EISENIA-BICYCLIS; RED ALGA
AB Background: Metabolic syndrome (MS) defines a group of severe comorbidities, including insulin resistance, abnormal fat accumulation, and high blood pressure that lead to obesity, diabetes, and heart diseases. MS has received a growing concern due to its rising prevalence in many countries. The consumption of high-calorie food, sedentary lifestyle habits, genetic factors, and stress conditions aggravate risk factors for developing metabolic syndrome. Investigations targeting the development of marine algae-based functional food products and drug candidates for attenuating MS have presently received increased attention.
   Scope and approach: This review delivers an overview of recent (past ten years) advancements in discovering marine algal natural products with therapeutic potential against metabolic syndrome. Pathophysiology of obesity, diabetes mellitus, hypertension, and the action mechanisms of algal natural products are taken into the discussion.
   Key findings and conclusions: Marine algae, a popular ingredient in East Asian cuisine, is proven to be a source of nutritional and biofunctional natural products with promising ability to remedy MS. These include bioactive polyphenols, sulfated polysaccharides, terpenoids, alkaloids, polyunsaturated fatty acids, and peptides with vast structural diversity. Moreover, algae are rich sources of dietary fibers that decrease the absorption of excessive nutrition and increase microbial functionality in the gut. By today, numerous algae-derived food supplements could be found in the market. The public should be educated on their beneficial effects, and research needs to be advance towards pre-clinical trials targeting the development of pharmaceuticals for the preventive and effective management of MS and its associated complications.
C1 [Fernando, Ilekuttige Priyan Shanura; Ryu, BoMi; Yeo, In-Kyu; Jeon, You-Jin] Jeju Natl Univ, Dept Marine Life Sci, Jeju 63243, South Korea.
   [Fernando, Ilekuttige Priyan Shanura; Ahn, Ginnae] Chonnam Natl Univ, Dept Marine Biofood Sci, Yeosu 59626, South Korea.
   [Ahn, Ginnae] Chonnam Natl Univ, Dept Food Technol & Nutr, Yeosu 59626, South Korea.
   [Jeon, You-Jin] Jeju Natl Univ, Marine Sci Inst, Jeju 63333, Jeju Self Gover, South Korea.
C3 Jeju National University; Chonnam National University; Chonnam National
   University; Jeju National University
RP Yeo, IK; Jeon, YJ (corresponding author), Jeju Natl Univ, Dept Marine Life Sci, Jeju 63243, South Korea.
EM ikyeo99@jejunu.ac.kr; youjin2014@gmail.com
RI Jeon, You-Jin/AAR-5061-2020; Ryu, Bomi/H-5795-2019; Fernando,
   Shanura/H-4422-2016
FU Ministry of Oceans and Fisheries, Korea
FX This research was a part of the project titled 'Development of
   functional food products with natural materials derived from marine
   resources', funded by the Ministry of Oceans and Fisheries, Korea.
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NR 103
TC 46
Z9 46
U1 4
U2 87
PU ELSEVIER SCIENCE LONDON
PI LONDON
PA 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND
SN 0924-2244
EI 1879-3053
J9 TRENDS FOOD SCI TECH
JI Trends Food Sci. Technol.
PD MAR
PY 2020
VL 97
BP 286
EP 299
DI 10.1016/j.tifs.2020.01.020
PG 14
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA KR8EI
UT WOS:000517848300024
DA 2025-06-11
ER

PT J
AU Nyirenda, MJ
   Carter, R
   Tang, JI
   de Vries, A
   Schlumbohm, C
   Hillier, SG
   Streit, F
   Oellerich, M
   Armstrong, VW
   Fuchs, E
   Seckl, JR
AF Nyirenda, Moffat J.
   Carter, Roderick
   Tang, Justin I.
   de Vries, Annick
   Schlumbohm, Christina
   Hillier, Stephen G.
   Streit, Frank
   Oellerich, Michael
   Armstrong, Victor W.
   Fuchs, Eberhard
   Seckl, Jonathan R.
TI Prenatal Programming of Metabolic Syndrome in the Common Marmoset Is
   Associated With Increased Expression of 11β-Hydroxysteroid Dehydrogenase
   Type 1
SO DIABETES
LA English
DT Article
ID TISSUE-SPECIFIC DYSREGULATION; GLUCOCORTICOID METABOLISM;
   INSULIN-RESISTANCE; GLUCOSE-METABOLISM; ADIPOSE-TISSUE; OBESITY;
   CORTISOL; RATS; DISEASE; MICE
AB OBJECTIVE-Recent studies in humans and animal models of obesity have shown increased adipose tissue activity of 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1), which amplifies local I issue glucocorticoid concentrations. The reasons for this 11 beta-HSD1 dystegulation are unknown. Here, we tested whether 11 beta-HSD1 expression, like the metabolic syndrome, is "programmed" by prenatal environmental events in a nonhuman primate model, the common marmoset monkey.
   RESEARCH DESIGN AND METHODS-We used a "fetal programming" paradigm where brief antenatal exposure to glucocorticoids leads to the metabolic syndrome in the offspring. Pregnant marmosets were given the synthetic glucocorticoid dexamethasone orally for 1 week in either early or late gestation, or they were given vehicle. Tissue 11 beta-HSD1 and glucocorticoid receptor mRNA expression were examined in the offspring at 4 and 24 months of age.
   RESULTS-Prenatal dexamethasone administration, selectively during late gestation, resulted in early and persistent elevations in 11 beta-HSD1 mRNA expression and activity in the liver, pancreas, and subcutaneous-but not visceral-fat. The increase in 11 beta-HSD1 occurred before animals developed obesity or overt features of the metabolic syndrome. In contrast to rodents, in utero dexamethasone exposure did not alter glucocorticoid receptor expression in metabolic tissues in marmosets.
   CONCLUSIONS-These data suggest that long-term upregulation of 11 beta-HSD1 in metabolically active tissues may follow prenatal "stress" hormone exposure and indicates a novel mechanism for fetal origins of adult obesity and the metabolic syndrome. Diabetes 58:2873-2879, 2009
C1 [Nyirenda, Moffat J.; Carter, Roderick; Tang, Justin I.; de Vries, Annick; Seckl, Jonathan R.] Univ Edinburgh, Endocrinol Unit, Queens Med Res Inst, Edinburgh EH8 9YL, Midlothian, Scotland.
   [Schlumbohm, Christina; Fuchs, Eberhard] Leibniz Inst Primate Res, Clin Neurobiol Lab, German Primate Ctr, Gottingen, Germany.
   [Hillier, Stephen G.] Univ Edinburgh, MRC, Reprod Sci Unit, Queens Med Res Inst, Edinburgh EH8 9YL, Midlothian, Scotland.
   [Streit, Frank; Oellerich, Michael; Armstrong, Victor W.] Univ Gottingen, Dept Clin Chem, Gottingen, Germany.
C3 University of Edinburgh; Leibniz Association; Deutsches Primatenzentrum
   (DPZ); University of Edinburgh; University of Gottingen
RP Seckl, JR (corresponding author), Univ Edinburgh, Endocrinol Unit, Queens Med Res Inst, Edinburgh EH8 9YL, Midlothian, Scotland.
EM j.seckl@ed.ac.uk
RI Nyirenda, Makandwe/R-4080-2018; de Vries, Annick/H-8648-2012; Seckl,
   Jonathan/C-3555-2013
OI hillier, stephen/0000-0001-7378-5855; Nyirenda,
   Moffat/0000-0003-2120-4806
FU European Commission [QLRT-2001-02758]; MRC; MRC [G0501934] Funding
   Source: UKRI
FX This work was supported by European Commission Grant QLRT-2001-02758
   (EUPEAH). M.J.N. is a recipient of an MRC clinician fellowship. A.d.V.
   is currently affiliated with the TMRC (Translational Medicine Research
   Collaboration) Laboratory, University of Dundee, U.K.
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NR 32
TC 57
Z9 68
U1 0
U2 4
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0012-1797
EI 1939-327X
J9 DIABETES
JI Diabetes
PD DEC
PY 2009
VL 58
IS 12
BP 2873
EP 2879
DI 10.2337/db09-0873
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 529MS
UT WOS:000272522000021
PM 19720800
OA Green Published, hybrid, Green Accepted
DA 2025-06-11
ER

PT J
AU Ferro, FED
   Lima, VBD
   Soares, NRM
   Cozzolino, SMF
   Marreiro, DD
AF Dourado Ferro, F. Ennes
   de Sousa Lima, V. B.
   Mello Soares, N. R.
   Franciscato Cozzolino, S. Ma
   do Nascimento Marreiro, D.
TI Biomarkers of metabolic syndrome and its relationship with the zinc
   nutritional status in obese women
SO NUTRICION HOSPITALARIA
LA English
DT Article
DE Obesity; Plasmatic zinc; Erythrocytary zinc; Metabolic syndrome
ID OXIDATIVE STRESS; LEPTIN LEVELS; SERUM LEPTIN; INSULIN; PLASMA;
   HYPOZINCEMIA
AB Introduction: Obesity is a chronic disease that induces risk factors for metabolic syndrome and, is associated with disturbances in the metabolism of the zinc. Therefore, the aim of this study was to investigate the existence of relationship between the biomarkers of metabolic syndrome and the zinc nutricional status in obese women.
   Method: Seventy-three premenopausal women, aged between 20 and 50 years, were divided into two groups: case group, composed of obese (n = 37) and control group, composed of no obese (n = 36). The assessment of the body mass index and waist circumference were carried out using anthropometric measurements. The plasmatic and erythrocytary zinc were analyzed by method atomic absorption spectrophotometry (lambda=213.9 nm).
   Results: In the study, body mass index and waist circumference were higher in obese women than control group (p < 0.05). The mean plasmatic zinc was 72.2 +/- 9.0 mu g/dl in obese women and 73.4 +/- 8.5 mu g/dl in control group (p > 0.05). The mean erythrocytary zinc was 36.4 +/- 15.0 mu g/gHb and 45.4 +/- 14.3 mu g/gHb in the obese and controls, respectively (p < 0.05). Regression analysis showed that the body mass index (t=-2.85) and waist circumference (t=-2.37) have a negative relationship only with the erythrocytary zinc (R-2=0.32, p < 0.05).
   Conclusions: The study shows that there are alterations in biochemical parameters of zinc in obese women, with low zinc concentrations in erythrocytes. Regression analysis demonstrates that the erythrocytary zinc is influenced by biomarkers of the metabolic syndrome, presenting an inverse relationship with the waist circumference and body mass index.
C1 [Dourado Ferro, F. Ennes; de Sousa Lima, V. B.; Mello Soares, N. R.; do Nascimento Marreiro, D.] Univ Fed Piaui, Dept Nutr, Teresina, Piaui, Brazil.
   [Franciscato Cozzolino, S. Ma] Univ Sao Paulo, Escuela Farm, Dept Ciencia Alimentac & Nutr Expt, Sao Paulo, Brazil.
C3 Universidade Federal do Piaui; Universidade de Sao Paulo
RP Marreiro, DD (corresponding author), Rua Hugo Napoleao 665,Apt 2001, BR-64048320 Teresina, Piaui, Brazil.
EM dilina.marreiro@gmail.com
RI Cozzolino, Silvia/K-7623-2016
CR Ancao MS, 2002, PROGRAMA APOIO NUTRI
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NR 30
TC 30
Z9 33
U1 0
U2 4
PU ARAN EDICIONES, S L
PI MADRID
PA C/ CASTELLO, 128, 1O, MADRID, 28006, SPAIN
SN 0212-1611
EI 1699-5198
J9 NUTR HOSP
JI Nutr. Hosp.
PD MAY-JUN
PY 2011
VL 26
IS 3
BP 650
EP 654
DI 10.3305/nh.2011.26.3.5221
PG 5
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 769AC
UT WOS:000290980400032
PM 21892588
DA 2025-06-11
ER

PT J
AU Basu, A
   Du, M
   Leyva, MJ
   Sanchez, K
   Betts, NM
   Wu, MY
   Aston, CE
   Lyons, TJ
AF Basu, Arpita
   Du, Mei
   Leyva, Misti J.
   Sanchez, Karah
   Betts, Nancy M.
   Wu, Mingyuan
   Aston, Christopher E.
   Lyons, Timothy J.
TI Blueberries Decrease Cardiovascular Risk Factors in Obese Men and Women
   with Metabolic Syndrome
SO JOURNAL OF NUTRITION
LA English
DT Article
ID C-REACTIVE PROTEIN; CORONARY-ARTERY-DISEASE; LOW-DENSITY-LIPOPROTEIN;
   NITRIC-OXIDE SYNTHASE; ANTIOXIDANT CAPACITY; BLOOD-PRESSURE;
   PHENOLIC-COMPOUNDS; OXIDATIVE STRESS; FLAVONOID INTAKE; HDL-CHOLESTEROL
AB Among all fruits, berries have shown substantial cardio-protective benefits due to their high polyphenol content. However, investigation of their efficacy in improving features of metabolic syndrome and related cardiovascular risk factors in obesity is limited. We examined the effects of blueberry supplementation on features of metabolic syndrome, lipid peroxidation, and inflammation in obese men and women. Forty-eight participants with metabolic syndrome [4 males and 44 females; BMI: 37.8 +/- 2.3 kg/m(2); age: 50.0 +/- 3.0 y (mean +/- SE)] consumed freeze-dried blueberry beverage (50 g freeze-dried blueberries, similar to 350 g fresh blueberries) or equivalent amounts of fluids (controls, 960 mL water) daily for 8 wk in a randomized controlled trial. Anthropometric and blood pressure measurements, assessment of dietary intakes, and fasting blood draws were conducted at screening and at wk 4 and 8 of the study. The decreases in systolic and diastolic blood pressures were greater in the blueberry-supplemented group (-6 and -4%, respectively) than in controls (-1.5 and -1.2%) (P < 0.05), whereas the serum glucose concentration and lipid profiles were not affected. The decreases in plasma oxidized LDL and serum malondialdehyde and hydroxynonenal concentrations were greater in the blueberry group (-28 and -17%, respectively) than in the control group (-9 and -9%) (P < 0.01). Our study shows blueberries may improve selected features of metabolic syndrome and related cardiovascular risk factors at dietary achievable doses. J. Nutr. 140: 1582-1587, 2010.
C1 [Basu, Arpita; Sanchez, Karah; Betts, Nancy M.] Oklahoma State Univ, Stillwater, OK 74078 USA.
   [Leyva, Misti J.; Aston, Christopher E.; Lyons, Timothy J.] Univ Oklahoma, Hlth Sci Ctr, Gen Clin Res Ctr, Oklahoma City, OK 73117 USA.
   [Du, Mei; Wu, Mingyuan; Lyons, Timothy J.] Univ Oklahoma, Hlth Sci Ctr, Harold Hamm Oklahoma Diabet Ctr, Oklahoma City, OK 73104 USA.
   [Du, Mei; Wu, Mingyuan; Lyons, Timothy J.] Univ Oklahoma, Hlth Sci Ctr, Sect Endocrinol & Diabet, Oklahoma City, OK 73104 USA.
C3 Oklahoma State University System; Oklahoma State University -
   Stillwater; University of Oklahoma System; University of Oklahoma Health
   Sciences Center; University of Oklahoma System; University of Oklahoma
   Health Sciences Center; University of Oklahoma System; University of
   Oklahoma Health Sciences Center
RP Basu, A (corresponding author), Oklahoma State Univ, Stillwater, OK 74078 USA.
EM arpita.basu@okstate.edu
OI Lyons, Timothy/0000-0003-2106-1622
FU US Highbush Blueberry Council; University of Oklahoma Health Sciences
   Center General Clinical Research Center [M01-RR14467]; National Center
   for Research Resources, NIH
FX Supported by the US Highbush Blueberry Council and by the University of
   Oklahoma Health Sciences Center General Clinical Research Center grant
   M01-RR14467, National Center for Research Resources, NIH.
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NR 49
TC 372
Z9 437
U1 1
U2 94
PU AMER SOC NUTRITIONAL SCIENCE
PI BETHESDA
PA 9650 ROCKVILLE PIKE, RM L-2407A, BETHESDA, MD 20814 USA
SN 0022-3166
J9 J NUTR
JI J. Nutr.
PD SEP
PY 2010
VL 140
IS 9
BP 1582
EP 1587
DI 10.3945/jn.110.124701
PG 6
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 642KE
UT WOS:000281210800008
PM 20660279
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Charmandari, E
   Kino, T
   Souvatzoglou, E
   Chrousos, GP
AF Charmandari, E
   Kino, T
   Souvatzoglou, E
   Chrousos, GP
TI Pediatric stress: Hormonal mediators and human development
SO HORMONE RESEARCH
LA English
DT Review
DE stress system; neuroendocrinology of stress; stress-related disorders
ID CORTICOTROPIN-RELEASING HORMONE; PITUITARY-ADRENAL AXIS;
   CENTRAL-NERVOUS-SYSTEM; GENE-EXPRESSION; NEUROPEPTIDE-Y; MATERNAL-CARE;
   BIOCHEMICAL MANIFESTATIONS; RECOMBINANT INTERLEUKIN-6; PARAVENTRICULAR
   NUCLEUS; POTENTIAL IMPLICATIONS
AB Stress activates the central and peripheral components of the stress system, i.e., the hypothalamic-pituitary-adrenal (HPA) axis and the arousal/sympathetic system. The principal effectors of the stress system are corticotropin-releasing hormone (CRH), arginine vasopressin, the proopiomelanocortin-derived peptides alpha-melanocyte-stimulating hormone and beta-endorphin, the glucocorticoids, and the catecholamines norepinephrine and epinephrine. Appropriate responsiveness of the stress system to stressors is a crucial prerequisite for a sense of well-being, adequate performance of tasks and positive social interactions. By contrast, inappropriate responsiveness of the stress system may impair growth and development, and may account for a number of endocrine, metabolic, autoimmune and psychiatric disorders. The development and severity of these conditions primarily depend on the genetic vulnerability of the individual, the exposure to adverse environmental factors and the timing of the stressful event(s), given that prenatal life, infancy, childhood and adolescence are critical periods characterized by increased vulnerability to stressors. The developing brain undergoes rapid growth and is characterized by high turnover of neuronal connections during the prenatal and early postnatal life. These processes and, hence, brain plasticity, slow down during childhood and puberty, and plateau in young adulthood. Hormonal actions in early life, and to a much lesser extent later, can be organizational, i.e., can have effects that last for long periods of time, often for the entire life of the individual. Hormones of the stress system and sex steroids have such effects, which influence the behavior and certain physiologic functions of individuals for life. Exposure of the developing brain to severe and/or prolonged stress may result in hyperactivity/hyperreactivity of the stress system, with resultant amygdala hyperfunction (fear reaction), decreased activity of the hippocampus (defective glucocorticoid-negative feedback, cognition), and the mesocorticolimbic dopaminergic system (dysthymia, novelty-seeking, addictive behaviors), hyperactivation of the HPA axis (hypercortisolism), suppression of reproductive, growth, thyroid and immune functions, and changes in pain perception. These changes may be accompanied by abnormal childhood, adolescent and adult behaviors, including excessive fear ('inhibited child syndrome') and addictive behaviors, dysthymia and/or depression, and gradual development of components of the metabolic syndrome X, including visceral obesity and essential hypertension. Prenatal stress exerted during the period of sexual differentiation may be accompanied by impairment of this process with behavioral and/or somatic sequelae. The vulnerability of individuals to develop varying degrees and/or components of the above life-long syndrome is defined by as yet unidentified genetic factors, which account for up to 60% of the variance. CRH has marked kindling and glucocorticoids have strong consolidating properties, hence both of these hormones are crucial in development and can alone produce the above syndrome. CRH and glucocorticoids may act in synergy, as in acoustic startle, while glucocorticoids may suppress or stimulate CRH, as in the hypothalamus and amygdala, respectively. A CRH type 1 receptor antagonist, antalarmin, inhibits both the development and expression of conditioned fear in rats, and has anxiolytic properties in monkeys. Profound stressors, such as those from sexual abuse, may elicit the syndrome in older children, adolescents and adults.
   Most frequently, chronic dysthymia and/or depression may develop in association with gastrointestinal complaints and/or the premenstrual tension syndrome. A lesser proportion of individuals may develop the classic posttraumatic stress disorder, which is characterized by hypocortisolism and intrusive and avoidance symptoms; in younger individuals it may present as dissociative personality disorder. Copyright (C) 2003 S. Karger AG, Basel.
C1 NICHHD, Pediat & Repord Endocrinol Branch, NIH, Bethesda, MD 20892 USA.
C3 National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver
   National Institute of Child Health & Human Development (NICHD)
RP NICHHD, Pediat & Repord Endocrinol Branch, NIH, 10 Ctr Dr,Bldg 10,Suite 9D42, Bethesda, MD 20892 USA.
EM charmane@mail.nih.gov
RI Charmandari, Evangelia/AAF-2038-2019
OI Charmandari, Evangelia/0000-0002-0851-6998
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NR 126
TC 279
Z9 321
U1 1
U2 86
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0301-0163
EI 1663-2826
J9 HORM RES
JI Horm. Res.
PY 2003
VL 59
IS 4
BP 161
EP 179
DI 10.1159/000069325
PG 19
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 664VP
UT WOS:000182083500001
PM 12649570
DA 2025-06-11
ER

PT J
AU Jimenez, DE
   Weinstein, ER
   Batsis, J
AF Jimenez, Daniel E. E.
   Weinstein, Elliott R. R.
   Batsis, John
TI You gotta walk the walk to talk the talk: protocol for a feasibility
   study of the Happy Older Latino Adults (HOLA) health promotion
   intervention for older HIV-positive Latino men
SO PILOT AND FEASIBILITY STUDIES
LA English
DT Article
DE Latinos; Older adults; Health promotion; HIV; Cardiometabolic risk
ID PHYSICAL-ACTIVITY; SOCIAL-ISOLATION; UNITED-STATES; CLINICAL-OUTCOMES;
   AFRICAN-AMERICAN; DEPRESSION; STIGMA; LONELINESS; DISEASE; IMPACT
AB BackgroundOlder Latinos living with the human immunodeficiency virus (HIV) have been disproportionately affected by the epidemic and experience compounded health disparities that have deepened over time. These health disparities are largely related to lifestyle and are either preventable or amenable to early detection or intervention. Despite existing resources to deliver an intervention to reduce this compounded health disparity, there is little information on the effects of health promotion interventions on indices of cardiometabolic risk in midlife and older Latinos living with HIV. The Happy Older Latinos are Active (HOLA) intervention is an innovative health promotion program that is uniquely tailored to meet the diverse needs and circumstances of older Latinos with HIV. The goal of this manuscript is to describe the protocol of a feasibility study of the HOLA health promotion intervention for older HIV-positive Latino men.Methods/designHOLA, which is informed by Behavioral Activation and Social Learning theory is a community health worker (CHW)-led, multicomponent, health promotion intervention consisting of: (1) a social and physical activation session; (2) a moderately intense group walk led by a CHW for 45 min, 3x/week for 16 weeks; (3) pleasant events (e.g., going to brunch with friends) scheduling. Eighteen community dwelling Latinos living with HIV aged 50+ will be recruited for this feasibility study adapting the HOLA intervention. Participants will be assessed at three time points (baseline, post-intervention, and 3 months post-intervention) on measures of cardiometabolic risk factors (waist circumference, dyslipidemia, hypertension, and glucose), psychosocial functioning, and health-related quality of life.ConclusionsIf HOLA can be delivered successfully by CHWs, then the scalability, accessibility, and potential for dissemination is increased. Additionally, this study will inform feasibility and identify modifications needed in the design of a larger hypothesis testing study.
C1 [Jimenez, Daniel E. E.] Univ Miami, Dept Psychiat & Behav Sci, Miller Sch Med, Miami, FL 33136 USA.
   [Weinstein, Elliott R. R.] Univ Miami, Dept Psychol, Miami, FL USA.
   [Batsis, John] Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Med, Div Geriatr Med, Chapel Hill, NC USA.
   [Batsis, John] Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Nutr, Chapel Hill, NC USA.
C3 University of Miami; University of Miami; University of North Carolina;
   University of North Carolina Chapel Hill; University of North Carolina;
   University of North Carolina Chapel Hill
RP Jimenez, DE (corresponding author), Univ Miami, Dept Psychiat & Behav Sci, Miller Sch Med, Miami, FL 33136 USA.
EM dej18@miami.edu
RI Batsis, John/AAC-7185-2019
OI Jimenez, Daniel E./0000-0003-2135-0619
FU National Institute on Minority Health and Health Disparities [R01
   MD012610, U54 MD002266]; National Institute on Aging [RO1 AG053163,
   K23-AG051681]
FX This research was supported by grants R01 MD012610 and U54 MD002266 from
   the National Institute on Minority Health and Health Disparities and RO1
   AG053163 from the National Institute on Aging. Dr. Batsis is supported
   by K23-AG051681 from the National Institute on Aging.
CR [Anonymous], COVID 19 RAC ETHN MI
   [Anonymous], UEQUALSU US
   [Anonymous], 90-90-90: Treatment for all
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NR 71
TC 0
Z9 0
U1 2
U2 6
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 2055-5784
J9 PILOT FEASIBILITY ST
JI Pilot Feasibility Stud.
PD FEB 28
PY 2023
VL 9
IS 1
AR 32
DI 10.1186/s40814-023-01262-w
PG 12
WC Medicine, Research & Experimental
WE Emerging Sources Citation Index (ESCI)
SC Research & Experimental Medicine
GA 9K5KL
UT WOS:000940906500003
PM 36855194
OA Green Submitted, gold, Green Published
DA 2025-06-11
ER

PT J
AU Dekker, MJ
   Su, QZ
   Baker, C
   Rutledge, AC
   Adeli, K
AF Dekker, Mark J.
   Su, Qiaozhu
   Baker, Chris
   Rutledge, Angela C.
   Adeli, Khosrow
TI Fructose: a highly lipogenic nutrient implicated in insulin resistance,
   hepatic steatosis, and the metabolic syndrome
SO AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
LA English
DT Review
DE hyperlipidemia; inflammation; gene expression; triglyceride; intestine
ID PROLIFERATOR-ACTIVATED RECEPTOR; NECROSIS-FACTOR-ALPHA; INTESTINAL
   LIPOPROTEIN OVERPRODUCTION; ENDOPLASMIC-RETICULUM STRESS;
   ELEMENT-BINDING PROTEIN-1C; HYPOTHALAMIC MALONYL-COA;
   LOW-DENSITY-LIPOPROTEIN; LEUCINE ZIPPER PROTEIN; DE-NOVO LIPOGENESIS;
   CARDIOVASCULAR-DISEASE
AB Dekker MJ, Su Q, Baker C, Rutledge AC, Adeli K. Fructose: a highly lipogenic nutrient implicated in insulin resistance, hepatic steatosis, and metabolic syndrome. Am J Physiol Endocrinol Metab 299: E685-E694, 2010. First published September 7, 2010; doi: 10.1152/ajpendo.00283.2010.-As dietary exposure to fructose has increased over the past 40 years, there is growing concern that high fructose consumption in humans may be in part responsible for the rising incidence of obesity worldwide. Obesity is associated with a host of metabolic challenges, collectively termed the metabolic syndrome. Fructose is a highly lipogenic sugar that has profound metabolic effects in the liver and has been associated with many of the components of the metabolic syndrome (insulin resistance, elevated waist circumference, dyslipidemia, and hypertension). Recent evidence has also uncovered effects of fructose in other tissues, including adipose tissue, the brain, and the gastrointestinal system, that may provide new insight into the metabolic consequences of high-fructose diets. Fructose feeding has now been shown to alter gene expression patterns (such as peroxisome proliferator-activated receptor-gamma coactivator-1 alpha/beta in the liver), alter satiety factors in the brain, increase inflammation, reactive oxygen species, and portal endotoxin concentrations via Toll-like receptors, and induce leptin resistance. This review highlights recent findings in fructose feeding studies in both human and animal models with a focus on the molecular and biochemical mechanisms that underlie the development of insulin resistance, hepatic steatosis, and the metabolic syndrome.
C1 [Dekker, Mark J.; Su, Qiaozhu; Baker, Chris; Rutledge, Angela C.; Adeli, Khosrow] Hosp Sick Children, Res Inst, Toronto, ON M5G 1X8, Canada.
   [Rutledge, Angela C.; Adeli, Khosrow] Univ Toronto, Dept Biochem, Toronto, ON, Canada.
C3 University of Toronto; Hospital for Sick Children (SickKids); University
   of Toronto
RP Adeli, K (corresponding author), Hosp Sick Children, Res Inst, Rm 3652,555 Univ Ave, Toronto, ON M5G 1X8, Canada.
EM khosrow.adeli@sickkids.ca
OI Su, Qiaozhu/0000-0001-8434-1408; Rutledge, Angela/0000-0001-9106-316X;
   Adeli, Khosrow/0000-0002-5839-5709
FU Canadian Institutes of Health Research (CIHR); Heart and Stroke
   Foundation (HSFO)
FX This work is supported by operating grants to K. Adeli by the Canadian
   Institutes of Health Research (CIHR) and the Heart and Stroke Foundation
   (HSFO). M. J. Dekker is supported by a Research Fellowship from HSFO; Q.
   Su is supported by a Research Fellowship from CIHR.
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NR 146
TC 319
Z9 352
U1 2
U2 59
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0193-1849
EI 1522-1555
J9 AM J PHYSIOL-ENDOC M
JI Am. J. Physiol.-Endocrinol. Metab.
PD NOV
PY 2010
VL 299
IS 5
BP E685
EP E694
DI 10.1152/ajpendo.00283.2010
PG 10
WC Endocrinology & Metabolism; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Physiology
GA 673LX
UT WOS:000283665600001
PM 20823452
DA 2025-06-11
ER

PT J
AU García-Muñoz, AM
   Garcia-Guillén, AI
   Victoria-Montesinos, D
   Abellán-Ruiz, MS
   Alburquerque-González, B
   Cánovas, F
AF Garcia-Munoz, Ana Maria
   Garcia-Guillen, Ana I.
   Victoria-Montesinos, Desiree
   Abellan-Ruiz, Maria Salud
   Alburquerque-Gonzalez, Begona
   Canovas, Fernando
TI Effect of the Combination of Hibiscus sabdariffa in Combination
   with Other Plant Extracts in the Prevention of Metabolic Syndrome: A
   Systematic Review and Meta-Analysis
SO FOODS
LA English
DT Review
DE metabolic syndrome; obesity; hypertension; dyslipidemia; polyphenols
ID DOUBLE-BLIND; LIPPIA-CITRIODORA; OXIDATIVE STRESS; BLOOD-PRESSURE; L.;
   HYPERTENSION; ANTIOXIDANT; EFFICACY; TEA; HYPERLIPIDEMIA
AB Metabolic syndrome is a complex and multifactorial disorder associated with increased risk of cardiovascular disease and type 2 diabetes, exacerbated by a sedentary lifestyle and situations such as the COVID-19 pandemic. Recent studies have shown that consumption of fruits and vegetables high in polyphenols has a protective effect, reducing cardiovascular risk. Hibiscus sabdariffa (HS) in combination with other plant extracts has recently attracted scientists' attention due to its potential use in the treatment of metabolic syndrome. This systematic review and meta-analysis examines the effects of HS in combination with other plant extracts on the prevention of metabolic syndrome, exploring their synergistic effects and potential as therapeutic agents. For this purpose, a systematic search of randomized clinical trials (RCTs) was conducted in four different databases and the data obtained were then used for a meta-analysis. Initially, the titles and abstracts of 1368 studies were read. From these, 16 studies were examined closely for their eligibility, and finally, seven RCTs with 332 participants were included in both the meta-analysis and the qualitative analysis. Our results show that HS in combination with other plant extracts improved anthropometric parameters, blood pressure, and lipid profile (low density lipoprotein cholesterol and total cholesterol) compared to a placebo control group. It is important to note that although this meta-analysis suggests that HS in combination with other plant extracts may have a beneficial effect on cardiovascular parameters, further research is needed to determine the optimal dose and intake duration.
C1 [Garcia-Munoz, Ana Maria; Victoria-Montesinos, Desiree] UCAM Univ Catolica San Antonio Murcia, Fac Pharm & Nutr, Murcia 30107, Spain.
   [Garcia-Guillen, Ana I.; Canovas, Fernando] UCAM Univ Catolica San Antonio Murcia, Fac Med, Murcia 30107, Spain.
   [Abellan-Ruiz, Maria Salud] UCAM Univ Catolica San Antonio Murcia, Fac Nursing, Murcia 30107, Spain.
   [Alburquerque-Gonzalez, Begona] UCAM Univ Catolica San Antonio Murcia, Lab Izpisua, HiTech, Sport & Hlth Innovat Hub, Murcia 30107, Spain.
C3 Universidad Catolica de Murcia; Universidad Catolica de Murcia;
   Universidad Catolica de Murcia; Universidad Catolica de Murcia
RP Victoria-Montesinos, D (corresponding author), UCAM Univ Catolica San Antonio Murcia, Fac Pharm & Nutr, Murcia 30107, Spain.; Garcia-Guillén, AI (corresponding author), UCAM Univ Catolica San Antonio Murcia, Fac Med, Murcia 30107, Spain.
EM igarcia53@ucam.edu; dvictoria@ucam.edu
RI Victoria-Montesinos, Desirée/S-2566-2018; García Muñoz, Ana
   María/AAU-9143-2020; Alburquerque González, Begoña/HKW-3633-2023;
   Canovas, Fernando/M-3457-2013
OI Canovas, Fernando/0000-0002-8837-1927; Garcia-Munoz/0000-0002-1021-5385;
   Victoria-Montesinos, Desiree/0000-0003-3968-9477; ABELLAN RUIZ, MARIA
   SALUD/0000-0003-2952-4783; Alburquerque Gonzalez,
   Begona/0000-0003-3413-5889; GARCIA GUILLEN, ANA
   ISABEL/0000-0002-1824-9272
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NR 78
TC 6
Z9 8
U1 1
U2 10
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2304-8158
J9 FOODS
JI Foods
PD JUN 5
PY 2023
VL 12
IS 11
AR 2269
DI 10.3390/foods12112269
PG 17
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA I9AJ5
UT WOS:001005632700001
PM 37297513
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Di Lorenzo, C
   Ballerini, G
   Barbanti, P
   Bernardini, A
   D'Arrigo, G
   Egeo, G
   Frediani, F
   Garbo, R
   Pierangeli, G
   Prudenzano, MP
   Rebaudengo, N
   Semeraro, G
   Sirianni, G
   Valente, M
   Coppola, G
   Cervenka, MC
   Spera, G
AF Di Lorenzo, Cherubino
   Ballerini, Giovanna
   Barbanti, Piero
   Bernardini, Andrea
   D'Arrigo, Giacomo
   Egeo, Gabriella
   Frediani, Fabio
   Garbo, Riccardo
   Pierangeli, Giulia
   Prudenzano, Maria Pia
   Rebaudengo, Nicoletta
   Semeraro, Grazia
   Sirianni, Giulio
   Valente, Mariarosaria
   Coppola, Gianluca
   Cervenka, Mackenzie C.
   Spera, Giovanni
TI Applications of Ketogenic Diets in Patients with Headache: Clinical
   Recommendations
SO NUTRIENTS
LA English
DT Review
DE ketogenic diets; ketosis; ketones; clinical recommendations; headache;
   migraine; cluster headache
ID VAGUS NERVE-STIMULATION; CORTICAL SPREADING DEPRESSION; GLYCEMIC-INDEX
   DIET; BETA-HYDROXYBUTYRATE; KETONE-BODIES; OXIDATIVE STRESS; HEMIPLEGIC
   MIGRAINE; METABOLIC SYNDROME; GUT MICROBIOTA; WEIGHT-GAIN
AB Headaches are among the most prevalent and disabling neurologic disorders and there are several unmet needs as current pharmacological options are inadequate in treating patients with chronic headache, and a growing interest focuses on nutritional approaches as non-pharmacological treatments. Among these, the largest body of evidence supports the use of the ketogenic diet (KD). Exactly 100 years ago, KD was first used to treat drug-resistant epilepsy, but subsequent applications of this diet also involved other neurological disorders. Evidence of KD effectiveness in migraine emerged in 1928, but in the last several year's different groups of researchers and clinicians began utilizing this therapeutic option to treat patients with drug-resistant migraine, cluster headache, and/or headache comorbid with metabolic syndrome. Here we describe the existing evidence supporting the potential benefits of KDs in the management of headaches, explore the potential mechanisms of action involved in the efficacy in-depth, and synthesize results of working meetings of an Italian panel of experts on this topic. The aim of the working group was to create a clinical recommendation on indications and optimal clinical practice to treat patients with headaches using KDs. The results we present here are designed to advance the knowledge and application of KDs in the treatment of headaches.
C1 [Di Lorenzo, Cherubino; Coppola, Gianluca] Sapienza Univ Rome, Dept Medicosurg Sci & Biotechnol, Polo Pontino, I-04100 Latina, Italy.
   [Ballerini, Giovanna] USL Toscana Ctr, Piero Palagi Hosp, Multidisciplinary Ctr Pain Therapy, I-50122 Florence, Italy.
   [Barbanti, Piero; Egeo, Gabriella] IRCCS San Raffaele Pisana, Headache & Pain Unit, I-00163 Rome, Italy.
   [Barbanti, Piero] San Raffaele Univ, Dept Neurosci & Rehabil, I-00163 Rome, Italy.
   [Bernardini, Andrea; Garbo, Riccardo; Valente, Mariarosaria] Misericordia Univ Hosp, Santa Maria Della Misericordia Univ Hosp, Clin Neurol Unit, I-33100 Udine, Italy.
   [D'Arrigo, Giacomo; Frediani, Fabio] ASST Santi Paolo & Carlo, San Carlo Borromeo Hosp, Headache Ctr, Neurol & Stroke Unit, I-20142 Milan, Italy.
   [Pierangeli, Giulia] IRCCS Ist Sci Neurol Bologna, I-40139 Bologna, Italy.
   [Pierangeli, Giulia] Univ Bologna, Dept Biomed & NeuroMotor Sci, I-40127 Bologna, Italy.
   [Prudenzano, Maria Pia] Univ Bari, Headache Ctr, Dept Basic Med Sci Neurosci & Sense Organs, I-70124 Bari, Italy.
   [Rebaudengo, Nicoletta] Humanitas Gradenigo, Neurol Serv, I-10153 Turin, Italy.
   [Semeraro, Grazia; Sirianni, Giulio] Assoc Eupraxia, Dietary Sect, I-00171 Rome, Italy.
   [Valente, Mariarosaria] Univ Udine, Dept Med DAME, Neurol Unit, Piazzale Santa Maria Della Misericordia 15, I-33100 Udine, Italy.
   [Cervenka, Mackenzie C.] Johns Hopkins Univ, Dept Neurol, Sch Med, Baltimore, MD 21287 USA.
   [Spera, Giovanni] Sapienza Univ Rome, Dept Expt Med, Sect Med Pathophysiol Food Sci & Endocrinol, I-00161 Rome, Italy.
C3 Sapienza University Rome; IRCCS San Raffaele Pisana; Vita-Salute San
   Raffaele University; Hospital Santa Maria della Misericordia; San Carlo
   Borromeo Hospital; IRCCS Istituto delle Scienze Neurologiche di Bologna
   (ISNB); University of Bologna; Universita degli Studi di Bari Aldo Moro;
   Humanitas Hospital Gradenigo; University of Udine; Johns Hopkins
   University; Sapienza University Rome
RP Di Lorenzo, C (corresponding author), Sapienza Univ Rome, Dept Medicosurg Sci & Biotechnol, Polo Pontino, I-04100 Latina, Italy.
EM cherub@inwind.it; giovannaballerini@icloud.com;
   piero.barbanti@sanraffaele.it; bernardini.an@gmail.com;
   giacomo.darrigo@gmail.com; gabriella.egeo@sanraffaele.it;
   fabio.frediani@asst-santipaolocarlo.it; riccardo.garbo@outlook.it;
   giulia.pierangeli@unibo.it; mariapia.prudenzano@virgilio.it;
   nicoletta.rebaudengo@gradenigo.it; grazia_smrr@libero.it;
   giulio.sirianni@gmail.com; mariarosaria.valente@uniud.it;
   gianluca.coppola@uniroma1.it; mcerven1@jhmi.edu; giannispera@yahoo.com
RI Bernardini, Andrea/N-2640-2016; Valente, Mariarosaria/AAC-4798-2022;
   Prudenzano, Maria/AAE-6550-2020; Coppola, Gianluca/K-6987-2016
OI Di Lorenzo, Cherubino/0000-0003-0845-5694; Prudenzano, Addolorata Maria
   Pia/0000-0001-9259-8158; /0000-0002-3193-8726; Coppola,
   Gianluca/0000-0002-8510-6925; Cervenka, Mackenzie/0000-0002-4760-857X;
   Bernardini, Andrea/0000-0002-0227-0659
FU Associazione Eupraxia
FX The study group activities were funded by Associazione Eupraxia; No
   funding source had any role in study design; collection, analysis, or
   interpretation of data; writing the report; or submission of the
   manuscript. All authors have read and agreed to the published version of
   the manuscript.
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NR 157
TC 31
Z9 31
U1 0
U2 14
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JUL
PY 2021
VL 13
IS 7
AR 2307
DI 10.3390/nu13072307
PG 26
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA TO5AS
UT WOS:000676924900001
PM 34371817
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Santana-Gálvez, J
   Cisneros-Zevallos, L
   Jacobo-Velázquez, DA
AF Santana-Galvez, Jesus
   Cisneros-Zevallos, Luis
   Jacobo-Velazquez, Daniel A.
TI Chlorogenic Acid: Recent Advances on Its Dual Role as a Food Additive
   and a Nutraceutical against Metabolic Syndrome
SO MOLECULES
LA English
DT Review
DE chlorogenic acid; 5-O-caffeoylquinic acid; metabolic syndrome;
   antibiotic; antioxidant; prebiotic
ID COFFEE BEAN EXTRACT; BLOOD-PRESSURE; ENDOTHELIAL FUNCTION;
   LIPID-PEROXIDATION; HEALTHY-VOLUNTEERS; OXIDATIVE STRESS; CARROT TISSUE;
   CAFFEIC ACID; LONG-TERM; IN-VITRO
AB Chlorogenic acid (5-O-caffeoylquinic acid) is a phenolic compound from the hydroxycinnamic acid family. This polyphenol possesses many health-promoting properties, most of them related to the treatment of metabolic syndrome, including anti-oxidant, anti-inflammatory, antilipidemic, antidiabetic, and antihypertensive activities. The first part of this review will discuss the role of chlorogenic acid as a nutraceutical for the prevention and treatment of metabolic syndrome and associated disorders, including in vivo studies, clinical trials, and mechanisms of action. The second part of the review will be dealing with the role of chlorogenic acid as a food additive. Chlorogenic acid has shown antimicrobial activity against a wide range of organisms, including bacteria, yeasts, molds, viruses, and amoebas. These antimicrobial properties can be useful for the food industry in its constant search for new and natural molecules for the preservation of food products. In addition, chlorogenic acid has antioxidant activity, particularly against lipid oxidation; protective properties against degradation of other bioactive compounds present in food, and prebiotic activity. The combination of these properties makes chlorogenic acid an excellent candidate for the formulation of dietary supplements and functional foods.
C1 [Santana-Galvez, Jesus; Jacobo-Velazquez, Daniel A.] Ctr Biotecnol FEMSA, Tecnol Monterrey, Escuela Ingn & Ciencias, Av Eugenio Garza Sada Sur 2501, Monterrey 64849, Mexico.
   [Cisneros-Zevallos, Luis] Texas A&M Univ, Dept Hort Sci, College Stn, TX 77843 USA.
C3 Tecnologico de Monterrey; Texas A&M University System; Texas A&M
   University College Station
RP Jacobo-Velázquez, DA (corresponding author), Ctr Biotecnol FEMSA, Tecnol Monterrey, Escuela Ingn & Ciencias, Av Eugenio Garza Sada Sur 2501, Monterrey 64849, Mexico.
EM jsantanag2000@gmail.com; lcisnero@tamu.edu; djacobov@itesm.mx
RI Jacobo-Velázquez, Daniel/AAG-5973-2020; Santana-Galvez,
   Jesus/P-5556-2016; Jacobo-Velazquez, Daniel Alberto/E-4225-2013
OI Santana-Galvez, Jesus/0000-0002-8766-5835; Jacobo-Velazquez, Daniel
   Alberto/0000-0002-9478-2570
FU Tecnologico de Monterrey (Bioprocess and Synthetic Biology Research
   Group); CONACYT [291137]
FX This study is based upon research supported by research funds from
   Tecnologico de Monterrey (Bioprocess and Synthetic Biology Research
   Group). Author J.S.-G. also acknowledges the scholarship (291137) from
   CONACYT.
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NR 81
TC 504
Z9 536
U1 45
U2 429
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1420-3049
J9 MOLECULES
JI Molecules
PD MAR
PY 2017
VL 22
IS 3
AR 358
DI 10.3390/molecules22030358
PG 21
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA ER4BH
UT WOS:000398743500019
PM 28245635
OA gold, Green Submitted, Green Published
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Merchant, N
   Rahman, ST
   Ahmad, M
   Parrott, JM
   Johnson, J
   Ferdinand, KC
   Khan, BV
AF Merchant, Nadya
   Rahman, Syed T.
   Ahmad, Mushtaq
   Parrott, Janice M.
   Johnson, Julie
   Ferdinand, Keith C.
   Khan, Bobby V.
TI Changes in biomarkers and 24 hours blood pressure in hypertensive
   African Americans with the metabolic syndrome: Comparison of
   amlodipine/olmesartan versus hydrochlorothiazide/losartan
SO JOURNAL OF THE AMERICAN SOCIETY OF HYPERTENSION
LA English
DT Article
DE Metabolic syndrome; African-American; inflammation; oxidation
ID PLASMINOGEN-ACTIVATOR INHIBITOR-1; TO-SEVERE HYPERTENSION; UNITED-STATES
   ADULTS; OLMESARTAN MEDOXOMIL; RESISTANT HYPERTENSION; CARDIOVASCULAR
   EVENTS; LIPID-PEROXIDATION; OXIDANT STRESS; DOUBLE-BLIND; PART 1
AB We evaluated the efficacy of amlodipine and olmesartan (A/O; Azor) versus losartan and hydrochlorothiazide (L/H; Hyzaar), on changes in serum and urine biomarkers of inflammation and oxidation, neutrophil reactive oxygen species generation, and changes in systolic blood pressure (BP), diastolic BP, and heart rate as measured with 24 hours ambulatory BP monitoring in a high-risk, hypertensive African-American population with the metabolic syndrome. Sixty-six African-American subjects with Stage 1 and 2 hypertension and characteristics of the metabolic syndrome were treated in open-label, active comparator fashion for 20 weeks. After 14 weeks of therapy, treatment with A/O had a significant effect on reducing the production of reactive oxygen series, plasminogen activator inhibitor-1, F-2 isoprostane, myeloperoxidase, and homeostasis model assessment for insulin resistance while L/H treatment only significantly lowered levels of plasminogen activator inhibitor-1 and homeostasis model assessment for insulin resistance. Treatment with A/O showed a trend of a more immediate and sustained systolic and diastolic BP-lowering, as well as night time BP reduction. In addition to a trend toward lower blood pressure, treatment with A/O in comparison with L/H has superior efficacy in reducing reactive oxygen species generation and production of inflammatory and oxidative biomarkers in a hypertensive African-American population with features of the metabolic syndrome. (c) 2013 American Society of Hypertension. All rights reserved.
C1 [Merchant, Nadya; Rahman, Syed T.; Parrott, Janice M.; Johnson, Julie; Ferdinand, Keith C.; Khan, Bobby V.] Atlanta Vasc Res Fdn, Atlanta, GA 30342 USA.
   [Ahmad, Mushtaq] Morehouse Univ, Sch Med, Atlanta, GA USA.
C3 Morehouse College
RP Khan, BV (corresponding author), Atlanta Vasc Res Fdn, 5673 Peachtree Dunwoody Rd,Ste 440, Atlanta, GA 30342 USA.
EM bobby.khan@atlantaclinicalresearch.com
RI Muafa, Hussein Mussa Ahmed/IWE-4818-2023
OI Muafa, Hussein Mussa Ahmed/0000-0002-5290-025X
FU Daiichi Sankyo, Inc.
FX This study was supported by an unrestricted grant from Daiichi Sankyo,
   Inc. to Drs Khan and Ferdinand, and the study drugs
   (amlodipine/olmesartan and losartan/HCTZ) were provided by Daiichi
   Sankyo, Inc.
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NR 64
TC 6
Z9 6
U1 0
U2 5
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1933-1711
EI 1878-7436
J9 J AM SOC HYPERTENS
JI J. Am. Soc. Hypertens.
PD SEP-OCT
PY 2013
VL 7
IS 5
BP 386
EP 394
DI 10.1016/j.jash.2013.05.001
PG 9
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 231TT
UT WOS:000325442000009
PM 23835112
DA 2025-06-11
ER

PT J
AU Salas, AL
   Mercado, MI
   Orqueda, ME
   Uriburu, FCM
   García, ME
   Pérez, MJ
   Alvarez, MD
   Ponessa, GI
   Maldonado, LM
   Zampini, IC
   Isla, MI
AF Salas, Ana L.
   Mercado, Maria Ines
   Orqueda, Maria Eugenia
   Uriburu, Florencia M. Correa
   Garcia, Maria Elena
   Perez, Maria Jorgelina
   Alvarez, Maria de los Angeles
   Ponessa, Graciela I.
   Maldonado, Luis Maldonado
   Zampini, Iris Catiana
   Isla, Maria Ines
TI Zuccagnia-type Propolis from Argentina: A potential functional
   ingredient in food to pathologies associated to metabolic syndrome and
   oxidative stress
SO JOURNAL OF FOOD SCIENCE
LA English
DT Article
DE Argentine propolis; chalcones; free-radical scavenging activity;
   metabolic syndrome; Zuccagnia punctata
ID RADICAL-SCAVENGING ACTIVITY; CHEMICAL-COMPOSITION; ANTIOXIDANT ACTIVITY;
   SAN-JUAN; CHALCONES; PUNCTATA; EXTRACTS; REGIONS; ANTIBACTERIAL;
   MANAGEMENT
AB The effect of Argentine propolis extracts against enzymes related to metabolic syndrome and oxidative stress, as well as the botanical origin of raw propolis, were studied. Histological and chemical analyses of propolis samples revealed that the botanical origin isZuccagnia punctata, an Argentine medicinal plant. The melissopalynological analysis showed both pollen grains ofZ. punctataand the other plant species. This result indicates that the differences found in the botanical remains compared to the palynological studies may have been caused by the bees selecting resinous shrubs mainly ofZ. punctatafor the production of propolis and other plants with flowers for the production of honey. The richness of propolis was remarkable in two flavonoid precursors (2 ',4 '-dihydroxy-3 '-methoxychalcone, 2 ',4 '-dihydroxychalcone), the major chemical components ofZ. punctata. The hydroalcoholic extracts of Argentine propolis andZ. punctatawere able to inhibit enzymes associated with the metabolic syndrome, including alpha-glucosidase, alpha-amylase and lipase, with IC(50)values between 7 to 14, 37 to 48, and 13 to 28 mu g/mL, respectively. Biological activity was mainly attributed to chalcones. Oxygen and nitrogen reactive species scavenging activity was determined by the assays of superoxide radical (O-2(center dot-)), hydroxyl radical (HO center dot), hydrogen peroxide (H2O2), nitric oxide (NO center dot), and cation radical (ABTS(center dot+)). Results showed SC(50)values between 115 to 278, 12.50 to 46; 39 to 92; 50 to 104.50 and 23 to 33.75 mu g/mL, respectively. This study suggests for the first time that propolis from Argentina is highly effective in inhibiting enzymes related to the metabolic syndrome and in free-radical scavenging that would justify its use as a dietary supplement or as a functional ingredient in special food. Practical Application Propolis from Catamarca, Argentina, is traditionally used as medicine and food. Its botanical origin isZuccagnia punctata, an endemic plant species popularly used as a medicine in Argentina. Propolis has the ability to regulate the activity of enzymes involved in the carbohydrate and lipid metabolism, and consequently in metabolic syndrome. Besides, its antioxidant capacity makes it a natural product that can be used as a dietary supplement or as a functional ingredient in special foods. It is important to highlight that in the Argentine Food Code, propolis was incorporated in 2008 as a dietary supplement and the present results give major added value to this product.
C1 [Salas, Ana L.; Orqueda, Maria Eugenia; Uriburu, Florencia M. Correa; Perez, Maria Jorgelina; Alvarez, Maria de los Angeles; Zampini, Iris Catiana; Isla, Maria Ines] CONICET UNT, Inst Bioprospecc & Fisiol Vegetal INBIOFIV, RA-4000 San Miguel De Tucuman, Tucuman, Argentina.
   [Salas, Ana L.; Uriburu, Florencia M. Correa; Zampini, Iris Catiana; Isla, Maria Ines] Univ Nacl Tucuman, Fac Ciencias Nat, RA-4000 San Miguel De Tucuman, Tucuman, Argentina.
   [Mercado, Maria Ines; Garcia, Maria Elena; Ponessa, Graciela I.; Zampini, Iris Catiana; Isla, Maria Ines] Fdn Miguel Lillo, Area Bot, Inst Morfol Vegetal, RA-4000 San Miguel De Tucuman, Tucuman, Argentina.
   [Uriburu, Florencia M. Correa; Maldonado, Luis Maldonado] Inst Nacl Tecnol Agr INTA, Estn Expt Agr Famailla, RA-4132 Famailla, Tucuman, Argentina.
C3 Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET);
   Universidad Nacional de Tucuman; Consejo Nacional de Investigaciones
   Cientificas y Tecnicas (CONICET); Miguel Lillo Foundation; Instituto
   Nacional de Tecnologia Agropecuaria (INTA)
RP Isla, MI (corresponding author), CONICET UNT, Inst Bioprospecc & Fisiol Vegetal INBIOFIV, RA-4000 San Miguel De Tucuman, Tucuman, Argentina.; Isla, MI (corresponding author), Univ Nacl Tucuman, Fac Ciencias Nat, RA-4000 San Miguel De Tucuman, Tucuman, Argentina.; Isla, MI (corresponding author), Fdn Miguel Lillo, Area Bot, Inst Morfol Vegetal, RA-4000 San Miguel De Tucuman, Tucuman, Argentina.
EM misla@tucbbs.com.ar
OI Alvarez, Maria de los Angeles/0000-0003-4505-438X; Salas, Ana
   Lilia/0000-0001-9574-9417; Maldonado, Luis/0000-0002-6717-8757; Zampini,
   Iris Catiana/0000-0001-7941-1678; Correa Uriburu, Florencia
   Maria/0000-0001-7233-9861
FU Secretaria de Ciencia, Arte e Innovacion Tecnologica (SCAYT, PIUNT),
   Argentina; Agencia Nacional de Promocion Cientifica y Tecnologica
   (ANPCyT) [3136, 4436]; Consejo Nacional de Investigaciones Cientificas y
   Tecnicas (CONICET), Argentina [PUE 2018-0011]
FX The authors would like to thank the following for their financial
   support Secretaria de Ciencia, Arte e Innovacion Tecnologica (SCAYT,
   PIUNT), Argentina, Agencia Nacional de Promocion Cientifica y
   Tecnologica (ANPCyT) PICT 2014 Number 3136 and PICT 2017 Number 4436 and
   Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET, PUE
   2018-0011), Argentina.
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NR 48
TC 6
Z9 6
U1 0
U2 11
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-1147
EI 1750-3841
J9 J FOOD SCI
JI J. Food Sci.
PD AUG
PY 2020
VL 85
IS 8
BP 2578
EP 2588
DI 10.1111/1750-3841.15323
EA JUL 2020
PG 11
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA MY2BH
UT WOS:000545596000001
OA Green Published
DA 2025-06-11
ER

PT J
AU Roohafza, H
   Sadeghi, M
   Naghnaeian, M
   Shokouh, P
   Ahmadi, A
   Sarrafzadegan, N
AF Roohafza, Hamidreza
   Sadeghi, Masoumeh
   Naghnaeian, Mina
   Shokouh, Pedram
   Ahmadi, Abdollah
   Sarrafzadegan, Nizal
TI Relationship between Metabolic Syndrome and Its Components with
   Psychological Distress
SO INTERNATIONAL JOURNAL OF ENDOCRINOLOGY
LA English
DT Article
ID 3RD NATIONAL-HEALTH; DEPRESSIVE SYMPTOMS; MAJOR DEPRESSION;
   BLOOD-PRESSURE; RISK; PREVALENCE; OBESITY; INFLAMMATION; STRESS;
   EPIDEMIOLOGY
AB Background. Metabolic syndrome (MetS) and psychological distress are hypothesized to have a bidirectional relationship. According to their high prevalence in most populations, appraisal of this theory would be of great clinical and research interest. Methods. Data were available as part of the Isfahan Healthy Heart Program (IHHP). A total of 9553 men and women aged >= 19 years from three counties in central Iran were selected. Measurements consisted of serologic tests, anthropometrics, and self-reported 12-item general health questionnaire. Logistic regression analysis was used to find the association between MetS, MetS components, and distress level. Results. The mean age of 9553 participants ( 50% male) was 38.7 +/- 15.8 years. After adjusting for demographic factors, MetS (OR = 1.25, 95% CI: 1.01-1.37), central obesity (OR = 1.40, 95% CI: 1.15-1.49), and hypertension (OR = 1.55, 95% CI: 1.42-1.70) were associated with high distress level. However, after adding smoking status and low-density lipoprotein cholesterol to the adjustment factors, hypertension (OR = 1.79, 95% CI: 1.53-1.98) and central obesity (OR = 1.41, 95% CI: 1.17-1.55), but not the MetS, remained significantly associated with distress level. Conclusion. The presence of association between the MetS as well as its key components and high distress level signifies the importance of integrating psychological assessment and intervention in the standard management of MetS patients.
C1 [Roohafza, Hamidreza; Naghnaeian, Mina; Shokouh, Pedram; Ahmadi, Abdollah; Sarrafzadegan, Nizal] Isfahan Univ Med Sci, Isfahan Cardiovasc Res Inst, Isfahan Cardiovasc Res Ctr, Esfahan 8187698191, Iran.
   [Sadeghi, Masoumeh] Isfahan Univ Med Sci, Isfahan Cardiovasc Res Inst, Cardiac Rehabil Res Ctr, Esfahan 8187698191, Iran.
C3 Isfahan University of Medical Sciences; Isfahan University of Medical
   Sciences
RP Sadeghi, M (corresponding author), Isfahan Univ Med Sci, Isfahan Cardiovasc Res Inst, Cardiac Rehabil Res Ctr, POB 81465-1148, Esfahan 8187698191, Iran.
EM m_sadeghi@crc.mui.ac.ir
RI Shokouh, Pedram/AAX-4572-2021; Ahmdi, Abdollah/J-7779-2019; Sadeghi,
   Masoumeh/W-2291-2017; Sarrafzadegan, Nizal/V-5826-2017
OI Shokouh, Pedram/0000-0002-4514-0045; Roohafza,
   Hamidreza/0000-0003-3582-0431; Sadeghi Mahonak,
   Masoumeh/0000-0001-7179-5558; Sarrafzadegan, Nizal/0000-0002-8352-0540
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NR 34
TC 9
Z9 11
U1 0
U2 7
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1687-8337
EI 1687-8345
J9 INT J ENDOCRINOL
JI Int. J. Endocrinol.
PY 2014
VL 2014
AR 203463
DI 10.1155/2014/203463
PG 5
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism
GA AA7ZT
UT WOS:000331316100001
PM 24672543
OA Green Submitted, gold, Green Published
DA 2025-06-11
ER

PT J
AU Taleghani, A
   Ayati, Z
   Eghbali, S
   Emami, SA
   Tayarani-Najaran, Z
AF Taleghani, Akram
   Ayati, Zahra
   Eghbali, Samira
   Emami, Seyed Ahmad
   Tayarani-Najaran, Zahra
TI Health benefits of Allium spp. in metabolic syndrome: A review
SO SOUTH AFRICAN JOURNAL OF BOTANY
LA English
DT Review
DE Allium; Organosulfur; Blood pressure; Diabetes; Dyslipidemia; Obesity
ID ONION PEEL EXTRACT; METHYL CYSTEINE SULFOXIDE; BLOOD-GLUCOSE LEVEL;
   TO-OBESE PATIENTS; OXIDATIVE STRESS; WELSH ONION; CEPA L.; STEROIDAL
   GLYCOSIDES; DIETARY ONION; HYDROALCOHOLIC EXTRACT
AB Allium species have been recommended in traditional medicine for its efficacy in treating a variety of diseases such as arthritis, cardiovascular and kidney diseases, diabetes, colds, flu, headache, cough, hemorrhage, atherosclerosis, asthma, cancer, colic and skin problems Notably, it has shown promise in mitigating inflammation, regulating blood sugar levels and reducing oxidative damage. Metabolic syndrome, a cardiovascular risk factor characterized by a cluster of metabolic irregularities, including obesity, dyslipidemia, hypertension, and type 2 diabetes mellitus, often precipitates insulin resistance and development of cardiovascular disease or diabetes. This review endeavors to explore the role of various Allium species on different aspect of metabolic syndrome. Bibliographic databases, including PubMed and Scopus, Science Direct and Google Scholar databases were searched for the collection of relevant information. The abundant biological benefits of Allium species against the metabolic syndrome can be attributed to compounds such as flavonoids, steroidal saponins, stilbenoids and organosulfur compounds (OSCs). Both extracts and isolated compounds have exhibited efficacy in reducing internal mediator of hypertension, cholesterol, triglycerides and low-density lipoprotein, showcasing favorable attributes in weight management and type 2 diabetes control. Organosulfur compounds, steroidal saponins and phenolics are among the large number of active components of the genus Allium, displaying multiple pharmacological actions, which are supported by in vitro, in vivo and clinical studies. Nevertheless, while the existing body of evidence underscores the potential of Allium genus and its active components in managing complications associated with metabolic syndrome, further clinical trials are warranted to support their efficacy and safety for clinical application. (c) 2024 SAAB. Published by Elsevier B.V. All rights reserved.
C1 [Taleghani, Akram] Gonbad Kavous Univ, Fac Sci, Dept Chem, Gonbad Kavous, Iran.
   [Ayati, Zahra] Mashhad Univ Med Sci, Med Toxicol Res Ctr, Mashhad, Iran.
   [Ayati, Zahra] Western Sydney Univ, NICM Hlth Res Inst, Penrith, Australia.
   [Eghbali, Samira] Birjand Univ Med Sci, Sch Pharm, Dept Pharmacognosy & Tradit Pharm, Birjand, Iran.
   [Emami, Seyed Ahmad] Mashhad Univ Med Sci, Sch Pharm, Dept Tradit Pharm, Mashhad, Iran.
   [Tayarani-Najaran, Zahra] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Targeted Drug Delivery Res Ctr, Mashhad, Iran.
   [Tayarani-Najaran, Zahra] Mashhad Univ Med Sci, Sch Pharm, Dept Pharmacodynam & Toxicol, Pharmacol, Mashhad, Iran.
C3 Mashhad University of Medical Sciences; Western Sydney University;
   Birjand University of Medical Sciences; Mashhad University of Medical
   Sciences; Mashhad University of Medical Sciences; Mashhad University of
   Medical Sciences
RP Tayarani-Najaran, Z (corresponding author), Mashhad Univ Med Sci, Sch Pharm, Dept Pharmacodynam & Toxicol, Pharmacol, Mashhad, Iran.
EM tayaraninz@mums.ac.ir
RI Tayarani-Najaran, Zahra/I-1999-2014; Eghbali, Samira/AAD-3651-2019;
   Emami, Seyed Ahmad/IZE-9039-2023; taleghani, akram/N-5954-2017
OI eghbali, samira/0000-0002-3416-8237; Emami, Seyed
   Ahmad/0000-0003-4298-3132; taleghani, akram/0000-0002-6553-0454
FU Research Council of Mashhad University of Medical Sciences
FX The study was funded by Research Council of Mashhad University of
   Medical Sciences.
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NR 268
TC 5
Z9 5
U1 2
U2 9
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0254-6299
EI 1727-9321
J9 S AFR J BOT
JI S. Afr. J. Bot.
PD APR
PY 2024
VL 167
BP 217
EP 255
DI 10.1016/j.sajb.2024.01.040
EA FEB 2024
PG 39
WC Plant Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences
GA MU9M1
UT WOS:001196266500001
DA 2025-06-11
ER

PT J
AU Li, SY
   Fei, ZB
   Xu, ZR
   Wang, JJ
   Jiang, ZY
   Xie, YJ
   Wang, YZ
   Huang, WH
   Sun, HX
AF Li, Shiyu
   Fei, Zhengbin
   Xu, Zhenrui
   Wang, Jiajia
   Jiang, Zhenyou
   Xie, Yajie
   Wang, Yuzhe
   Huang, Wenhua
   Sun, Hanxiao
TI Enterococcus faecalis sir2-like gene enhances aerobic metabolism
   of themselves and mitochondrial respiration of mammal cells to bring
   about improving metabolic syndrome through the PGC-1α pathway
SO JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
LA English
DT Article
DE cellular energy; metabolic syndrome; NRF1; PGC-1 alpha; probiotics;
   sir2-like gene
ID BIFIDOBACTERIUM-LONGUM; OXIDATIVE STRESS; SIRT3; DEACETYLASE; PROTEINS;
   SIRTUINS; LDH
AB Recent studies showed that probiotics could improve metabolic syndrome, making the identification of factors affecting metabolic control more important than ever. The mammalian sirtuin protein family has received much attention for its regulatory role, especially in various mitochondrial ATP, glucose, and lipid metabolic pathways. However, compared with the mammalian sirtuin protein family, the function of prokaryotic sir2 protein is much less known. We studied the effects of probiotics sir2 protein on cell energy metabolize pathway, which showed that deletion of Enterococcus faecalis sir2 inhibited the aerobic oxidation of bacteria and increased the bacterial fermentation. The study of EF-sir2 (sir2 protein of E. faecalis) role of molecular targets demonstrated that deacetylation of EF-sir2 was via Rho upregulating in E. faecalis. When transfected into HEK293T cells, EF-sir2 could significantly facilitate aerobic oxidation of glucose, enhance the respiration to generate more ATP, and cause upregulation of NRF1 target gene. Then, we found EF-sir2 could increase activity of PGC-1 alpha by deacetylation and PGC-1 alpha inhibition decreased the expression of NRF1 target gene. Finally, we demonstrated that EF-sir2 could significantly improve the metabolic index of mammalian cells through insulin resistanced model in vitro and metabolic syndrome rat model in vivo. Our results first revealed that prokaryotic sir2 genes affect the molecular mechanism of cellular metabolism and the regulatory of cell homeostasis in prokaryotic and mammalian cells, suggesting that EF-sir2 has a positive regulatory effect on metabolic disturbance and may be used for the prevention and treatment of pathological processes related to metabolic syndrome.
C1 [Li, Shiyu; Huang, Wenhua] Southern Med Univ, Sch Basic Med Sci, Dept Anat, Guangzhou 510515, Guangdong, Peoples R China.
   [Fei, Zhengbin; Xu, Zhenrui; Wang, Jiajia; Xie, Yajie; Wang, Yuzhe; Sun, Hanxiao] Jinan Univ, Coll Pharm, Inst Genom Med, Guangzhou 510632, Guangdong, Peoples R China.
   [Jiang, Zhenyou] Jinan Univ, Dept Microbiol, Guangzhou, Guangdong, Peoples R China.
   [Jiang, Zhenyou] Jinan Univ, Dept Immunol, Guangzhou, Guangdong, Peoples R China.
C3 Southern Medical University - China; Jinan University; Jinan University;
   Jinan University
RP Huang, WH (corresponding author), Southern Med Univ, Sch Basic Med Sci, Dept Anat, Guangzhou 510515, Guangdong, Peoples R China.; Sun, HX (corresponding author), Jinan Univ, Coll Pharm, Inst Genom Med, Guangzhou 510632, Guangdong, Peoples R China.
EM huangwh@163.com; sunhx718@126.com
RI Li, Shiyu/AGE-9975-2022; huang, wenhua/AAO-5990-2020; Wang,
   Jiajia/HCI-5717-2022
OI Li, Shiyu/0000-0002-2045-0012
FU National Natural Science Foundation of China, NSFC [3087221]; Natural
   Science Foundation of Guangdong Province [2015A030313331]; National Key
   Technologies R&D Program of China [2017YFC1103403]
FX National Natural Science Foundation of China, Grant/Award Number: NSFC,
   3087221; Natural Science Foundation of Guangdong Province, Grant/Award
   Number: 2015A030313331; National Key Technologies R&D Program of China,
   Grant/Award Number: 2017YFC1103403
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NR 37
TC 4
Z9 4
U1 0
U2 31
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1932-6254
EI 1932-7005
J9 J TISSUE ENG REGEN M
JI J. Tissue Eng. Regen. Med.
PD FEB
PY 2019
VL 13
IS 2
BP 143
EP 155
DI 10.1002/term.2775
PG 13
WC Cell & Tissue Engineering; Biotechnology & Applied Microbiology; Cell
   Biology; Engineering, Biomedical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Biotechnology & Applied Microbiology; Engineering
GA HM9RT
UT WOS:000459823400003
PM 30512225
DA 2025-06-11
ER

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AF Civelek, Sabiha
   Konukoglu, Dildar
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   Uzun, Hafize
TI Serum Neurotrophic Factor Levels in Patients with Type 2 Diabetes
   Mellitus: Relationship to Metabolic Syndrome Components
SO CLINICAL LABORATORY
LA English
DT Article
DE brain-derived neurotrophic factor; nerve growth factor; neurotrophin-3;
   type 2 diabetes mellitus; metabolic syndrome
ID GLUCOSE-METABOLISM; INSULIN-RESISTANCE; FEMALE-PATIENTS; FACTOR BDNF;
   DISEASE; OBESITY; MICE; PATHOGENESIS; INFLAMMATION; STRESS
AB Background: It has been thought that neurotrophins have metabotrophic effects and take part in the carbohydrate and lipid metabolism. The aim of the present study is to examine the levels of neurotrophins in type 2 diabetes mellitus (T2DM) and whether the levels are linked to the components of metabolic syndrome.
   Methods: 90 patients and 35 healthy controls were enrolled in this study. The brain-derived neurotrophic factor, nerve growth factor, and neurotrophin-3 were measured using an enzyme-linked immunosorbent assay. Plasma glucose, insulin, systolic blood pressure, diastolic blood pressure, and body mass index were measured, and, for each subject, the homeostasis model assessment of insulin resistance was calculated as the index of metabolic syndrome.
   Results: The serum levels of brain-derived neurotrophic factor and neurotrophin-3 levels were higher, nerve growth factor lower in the T2DM patients than those of healthy controls (p < 0.001, p < 0. 001, and p < 0.001, respectively). The neurotrophic factor levels did not display any difference with respect to gender. The brain-derived neurotrophic factor was correlated with neurotrophin-3 level in female T2DM patients. In the male patients, brain-derived neurotrophic factor was correlated positively with plasma insulin and the homeostasis model assessment of insulin resistance; neurotrophin-3 was correlated positively with both systolic blood pressure and diastolic blood pressure, and nerve growth factor was correlated negatively with plasma glucose.
   Conclusions: We thought that the changes in the serum neurotrophic factor levels were associated with metabolic syndrome components in T2DM.
C1 [Civelek, Sabiha; Konukoglu, Dildar; Uzun, Hafize] Istanbul Univ, Cerrahpasa Med Fac, Dept Med Biochem, TR-34303 Istanbul, Turkey.
   [Erdenen, Fusun] Istanbul Educ & Res Hosp, Dept Internal Med, Istanbul, Turkey.
C3 Istanbul University - Cerrahpasa; Istanbul University; Istanbul Training
   & Research Hospital
RP Civelek, S (corresponding author), Istanbul Univ, Cerrahpasa Med Fac, Dept Med Biochem, TR-34303 Istanbul, Turkey.
EM sabihacivelek@hotmail.com
RI Konukoglu, Dildar/D-4951-2019; Uzun, Hafize/D-4811-2019
OI Konukoglu, Dildar/0000-0002-6095-264X; Uzun, Hafize/0000-0002-1347-8498
CR Barth R J., 2011, S D Med
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NR 28
TC 20
Z9 22
U1 0
U2 5
PU CLIN LAB PUBL
PI HEIDELBERG
PA IM BREITSPIEL 15, HEIDELBERG, D-69126, GERMANY
SN 1433-6510
J9 CLIN LAB
JI Clin. Lab.
PY 2013
VL 59
IS 3-4
BP 369
EP 374
DI 10.7754/Clin.Lab.2012.120404
PG 6
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA 278TP
UT WOS:000328913000018
PM 23724627
DA 2025-06-11
ER

PT J
AU Kantar, S
   Türközkan, N
   Bircan, FS
   Pasaoglu, OT
AF Kantar, Serife
   Turkozkan, Nurten
   Bircan, Filiz Sezen
   Pasaoglu, Ozge Tugce
TI Beneficial effects of melatonin on serum nitric oxide, homocysteine, and
   ADMA levels in fructose-fed rats
SO PHARMACEUTICAL BIOLOGY
LA English
DT Article
DE Hypertension; insulin resistance; metabolic syndrome
ID INCREASED ASYMMETRIC DIMETHYLARGININE; PERFORMANCE
   LIQUID-CHROMATOGRAPHY; INDUCED METABOLIC SYNDROME; HUMAN UMBILICAL
   ARTERY; INSULIN-RESISTANCE; OXIDATIVE STRESS; HYPERTENSIVE-RATS; INDUCED
   VASOCONSTRICTION; HUMAN-PLASMA; WISTAR RATS
AB Context: Melatonin, a pineal hormone and a potent antioxidant, has important roles in metabolic regulation.
   Objective: This study investigated serum asymmetric dimethylarginine (ADMA), homocysteine (Hcy), nitric oxide (NO) levels, known to be reliable markers of cardiovascular diseases, and determined possible protective effects of melatonin in fructose-fed rats.
   Materials and methods: Sprague-Dawley rats were divided into four groups: control, fructose, melatonin, and fructose plus melatonin. Metabolic syndrome was induced in rats by 20% (w/v) fructose solution in tap water, and melatonin was administered at the dose of 20 mg/kg bw per day by oral gavage. After 8 weeks, serum lipids, glucose, insulin, ADMA, Hcy, and NOx (the stable end products of NO) levels were quantified.
   Results: Fructose administration caused a statistically significant increase in systolic blood pressure (SBP), serum insulin, triglycerides, and very low-density lipoprotein (VLDL)-cholesterol levels compared with the control group and the metabolic syndrome model was successfully demonstrated. In comparison with the control group, fructose caused a significant increase in serum ADMA, Hcy, and NOx levels. Melatonin counteracted the changes in SBP, serum ADMA, and Hcy levels found in rats both alone and administered with fructose.
   Discussion and conclusion: These results show that high fructose consumption leads to elevated SBP, atherogenic lipid profile, increased serum ADMA, and Hcy levels and melatonin treatment has beneficial effects on these biochemical parameters in rats. Melatonin might be beneficial for the prevention and/or treatment of the cardiovascular complications of metabolic syndrome not only by reducing the well-known risk factors of the disease but also by diminishing blood ADMA and Hcy levels.
C1 [Kantar, Serife; Turkozkan, Nurten; Pasaoglu, Ozge Tugce] Gazi Univ, Fac Med, Dept Biochem, TR-06500 Ankara, Turkey.
   [Bircan, Filiz Sezen] Gazi Univ, Fac Sci, Dept Biol, TR-06500 Ankara, Turkey.
C3 Gazi University; Gazi University
RP Bircan, FS (corresponding author), Gazi Univ, Fac Sci, Dept Biol, TR-06500 Ankara, Turkey.
EM fsbircan@yahoo.com
RI Pasaoglu, Ozge/AAZ-5223-2020
OI Bircan, Filiz Sezen/0000-0002-1007-2484
FU Gazi University, Department of Scientific Research Projects Unit
   [01/2010-17]; TUBITAK (The Scientific and Technological Research Council
   of Turkey)
FX The authors declare that they have no conflict of interest. This study
   was supported by Gazi University, Department of Scientific Research
   Projects Unit (Project no. 01/2010-17). The authors thank TUBITAK (The
   Scientific and Technological Research Council of Turkey) for the
   fellowship to F. S. B.
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NR 48
TC 23
Z9 23
U1 0
U2 10
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1388-0209
EI 1744-5116
J9 PHARM BIOL
JI Pharm. Biol.
PY 2015
VL 53
IS 7
BP 1035
EP 1041
DI 10.3109/13880209.2014.957782
PG 7
WC Plant Sciences; Medical Laboratory Technology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Medical Laboratory Technology; Pharmacology & Pharmacy
GA CR4UX
UT WOS:000361336300012
PM 25609150
DA 2025-06-11
ER

PT J
AU Greenstone, H
   Burlingham, A
AF Greenstone, Harriet
   Burlingham, Amy
TI Where's that stethoscope? A survey of psychiatrists' attitudes to their
   role in managing physical health
SO JOURNAL OF MENTAL HEALTH TRAINING EDUCATION AND PRACTICE
LA English
DT Article
DE Psychiatry; Cardiometabolic risk; Interface between psychiatry and
   primary care; Physical health; Postgraduate psychiatry training
ID SEVERE MENTAL-ILLNESS; PEOPLE; LIFE
AB Purpose
   This study aims to explore current attitudes among doctors working in psychiatry, with regard to their perceived role and their confidence in managing their patients' physical health problems.
   Design/methodology/approach
   A 20-item electronic questionnaire was distributed to doctors working in psychiatry within two large UK mental health trusts in 2018. Quantitative analysis was conducted, alongside qualitative analysis of free-text comments made by participants.
   Findings
   Many participants perceived their physical examination skills to have deteriorated since working in psychiatry (78 per cent). Participants were questioned on which professional group should hold responsibility for managing the physical health of patients under psychiatric services. A minority felt it should be psychiatrist-led (5 per cent), followed by general practitioner (GP)-led (42 per cent) and then shared responsibility (47 per cent). The majority felt there should be more focused training on physical health in the Core (72 per cent) and Advanced (63 per cent) psychiatry training. Key themes from a framework analysis of qualitative data included potential barriers to shared care, psychiatrists' concerns regarding their experience and confidence in managing physical health, reasons in favour of shared responsibility, ideas for training and suggestions for improving the current situation.
   Originality/value
   Psychiatric patients may engage less well with health services, yet psychiatric medication often impacts significantly on physical health. In this context, there is often a blurring of role boundaries between a psychiatrist and a GP, and there is considerable variation between individual teams. There is a consistent call for more physical health training opportunities for psychiatrists and for mental health services to more proactively promote the physical health of their patients.
C1 [Greenstone, Harriet] Avon & Wiltshire Mental Hlth Partnership NHS Trus, Med Educ Dept, Bristol, Avon, England.
   [Burlingham, Amy] Birmingham & Solihull Mental Hlth NHS Fdn Trust, Solihull Early Intervent Serv, Birmingham, W Midlands, England.
RP Greenstone, H (corresponding author), Avon & Wiltshire Mental Hlth Partnership NHS Trus, Med Educ Dept, Bristol, Avon, England.
EM harriet.greenstone@nhs.net
OI Burlingham, Amy/0000-0001-9388-7648
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NR 24
TC 3
Z9 3
U1 0
U2 0
PU EMERALD GROUP PUBLISHING LTD
PI BINGLEY
PA HOWARD HOUSE, WAGON LANE, BINGLEY BD16 1WA, W YORKSHIRE, ENGLAND
SN 1755-6228
EI 2042-8707
J9 J MENT HEALTH TRAIN
JI J. Ment. Health Train. Educ. Pract.
PD FEB 12
PY 2020
VL 15
IS 3
BP 141
EP 155
DI 10.1108/JMHTEP-10-2019-0056
EA FEB 2020
PG 15
WC Psychiatry
WE Emerging Sources Citation Index (ESCI)
SC Psychiatry
GA LL9BB
UT WOS:000514243700001
DA 2025-06-11
ER

PT J
AU Hachiya, R
   Tanaka, M
   Itoh, M
   Suganami, T
AF Hachiya, Rumi
   Tanaka, Miyako
   Itoh, Michiko
   Suganami, Takayoshi
TI Molecular mechanism of crosstalk between immune and metabolic systems in
   metabolic syndrome
SO INFLAMMATION AND REGENERATION
LA English
DT Review
DE TLR4; Mincle; Fatty acids; Crown-like structure; Obesity; Metabolic
   syndrome
ID ADIPOSE-TISSUE INFLAMMATION; FATTY LIVER-DISEASE; C-TYPE LECTIN;
   INSULIN-RESISTANCE; OBESITY; TRANSCRIPTION; MACROPHAGES; ADIPOCYTES;
   RECEPTOR; EXPRESSION
AB Chronic inflammation is currently considered as a molecular basis of metabolic syndrome. Particularly, obesity-induced inflammation in adipose tissue is the origin of chronic inflammation of metabolic syndrome. Adipose tissue contains not only mature adipocytes with large lipid droplets, but also a variety of stromal cells including adipocyte precursors, vascular component cells, immune cells, and fibroblasts. However, crosstalk between those various cell types in adipose tissue in obesity still remains to be fully understood. We focus on two innate immune receptors, Toll-like receptor 4 (TLR4) and macrophage-inducible C-type lectin (Mincle). We provided evidence that adipocyte-derived saturated fatty acids (SFAs) activate macrophage TLR4 signaling pathway, thereby forming a vicious cycle of inflammatory responses during the development of obesity. Intriguingly, the TLR4 signaling pathway is modulated metabolically and epigenetically: SFAs augment TLR4 signaling through the integrated stress response and chromatin remodeling, such as histone methylation, regulates dynamic transcription patterns downstream of TLR4 signaling. Another innate immune receptor Mincle senses cell death, which is a trigger of chronic inflammatory diseases including obesity. Macrophages form a histological structure termed "crown-like structure (CLS)", in which macrophages surround dead adipocytes to engulf cell debris and residual lipids. Mincle is exclusively expressed in macrophages forming the CLS in obese adipose tissue and regulates adipocyte death-triggered adipose tissue fibrosis. In addition to adipose tissue, we found a structure similar to CLS in the liver of nonalcoholic steatohepatitis (NASH) and the kidney after acute kidney injury. This review article highlights the recent progress of the crosstalk between immune and metabolic systems in metabolic syndrome, with a focus on innate immune receptors.
C1 [Hachiya, Rumi] Keio Univ, Dept Pediat, Sch Med, Tokyo, Japan.
   [Hachiya, Rumi] Tokyo Dent Coll, Dept Pediat, Ichikawa Gen Hosp, Chiba, Japan.
   [Tanaka, Miyako; Suganami, Takayoshi] Nagoya Univ, Res Inst Environm Med, Dept Mol Med & Metab, Nagoya, Aichi, Japan.
   [Tanaka, Miyako; Suganami, Takayoshi] Nagoya Univ, Dept Immunometab, Grad Sch Med, Nagoya, Aichi, Japan.
   [Itoh, Michiko] Nagoya Univ, Dept Metab Syndrome & Nutr Sci, Res Inst Environm Med, Nagoya, Aichi, Japan.
   [Itoh, Michiko] Kanagawa Inst Ind Sci & Technol, Ebina, Kanagawa, Japan.
C3 Keio University; Tokyo Dental College; Nagoya University; Nagoya
   University; Nagoya University
RP Suganami, T (corresponding author), Nagoya Univ, Res Inst Environm Med, Dept Mol Med & Metab, Nagoya, Aichi, Japan.; Suganami, T (corresponding author), Nagoya Univ, Dept Immunometab, Grad Sch Med, Nagoya, Aichi, Japan.
EM suganami@riem.magoya-u.ac.jp
RI Hachiya, Rumi/ABF-5457-2021; SUGANAMI, Takayoshi/A-9475-2016; Itoh,
   Michiko/LDV-8630-2024
OI Hachiya, Rumi/0000-0001-8412-3494; Suganami,
   Takayoshi/0000-0002-1918-0465
FU Ministry of Education, Culture, Sports, Science and Technology of Japan
   [20H03447, 20H05503, 20H04944, 19 K09038]; Japan Agency for Medical
   Research and Development (CREST) [JP20gm1210009s0102, 20fk0210082s0101];
   FGHR (Forum on Growth Hormone Research) Clinical Research Grant;
   Grants-in-Aid for Scientific Research [20H03447, 20H05503, 20H04944]
   Funding Source: KAKEN
FX This work was supported by Grants-in-Aid for Scientific Research from
   the Ministry of Education, Culture, Sports, Science and Technology of
   Japan (20H03447, 20H05503, and 20H04944 to T.S.; 19 K09038 to R.H.),
   Japan Agency for Medical Research and Development (CREST)
   (JP20gm1210009s0102 and 20fk0210082s0101 to T.S.), and FGHR (Forum on
   Growth Hormone Research) Clinical Research Grant (R.H.).
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NR 64
TC 27
Z9 27
U1 2
U2 24
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1880-8190
J9 INFLAMM REGEN
JI Inflamm. Regen.
PD MAY 1
PY 2022
VL 42
IS 1
AR 13
DI 10.1186/s41232-022-00198-7
PG 8
WC Immunology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Research & Experimental Medicine
GA 0W5GN
UT WOS:000789055100001
PM 35490239
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Galiuto, L
   Sestito, A
   Barchetta, S
   Sgueglia, GA
   Infusino, F
   La Rosa, C
   Lanza, G
   Crea, F
AF Galiuto, Leonarda
   Sestito, Alfonso
   Barchetta, Sabrina
   Sgueglia, Gregory A.
   Infusino, Fabio
   La Rosa, Claudio
   Lanza, Gaetano
   Crea, Filippo
TI Noninvasive evaluation of flow reserve in the left anterior descending
   coronary artery in patients with cardiac syndrome X
SO AMERICAN JOURNAL OF CARDIOLOGY
LA English
DT Article
ID MYOCARDIAL BLOOD-FLOW; ANGINA-PECTORIS; CONTRAST ECHOCARDIOGRAPHY;
   DOPPLER-ECHOCARDIOGRAPHY; VELOCITY RESERVE; PERFUSION; QUANTIFICATION;
   ANGIOGRAMS; ULTRASOUND; STENOSIS
AB Data on coronary flow reserve (CFR) in patients with syndrome X are still controversial. Further, noninvasive evaluation of epicardial and microvascular flow reserves in these patients has never been performed. In 17 patients with syndrome X and in 17 age- and gender-matched control subjects, CFR in the mid left anterior descending coronary artery (LAD) was evaluated by transthoracic color and pulse-Wave Doppler using a 7-mHz probe (Sequoia, Siemens). Peak diastolic LAD flow was calculated at rest and at peak adenosine (140 p,g/kg/min intravenously in 90 seconds). Myocardial contrast echocardiography (MCE) was performed at rest and during adenosine use by real-time cadence pulse sequencing and intravenous SonoVue (Bracco; 5 ml at 1 ml/min) and microvascular blood volume (A), velocity (beta), and flow (A x beta) by replenishing curves (y = A[1 - e(beta t)]). CFR was measured by Doppler echocardiography as an adenosine/rest velocity ratio and by NICE as a microvascular volume, velocity, and. flow adenosine/rest ratio. Compared with controls, patients with syndrome X demonstrated lower LAD CFR and velocity and flow microvascular flow reserves (p <0.01, <0.005, and <0.005, respectively). In patients with syndrome X, those with angina and ST-segment depression during adenosine testing had even lower LAD CFR and velocity and flow microvascular flow reserves compared with those with no symptoms (p <0.0001, <0.0001, and <0.005, respectively). LAD CFR demonstrated a significant linear correlation with velocity microvascular flow reserve (r = 0.92, p <0.0001) and flow microvascular flow reserve (r = 0.77, p <0.0001). In conclusion, CFR in the LAD, successfully evaluated by transthoracic Doppler echocardiography and MCE, is significantly decreased in patients with syndrome X and even more in those with angina pectoris and ST-segment depression during adenosine testing. Thus, noninvasive evaluation of CFR by echocardiography is feasible and provides information on the severity of microvascular impairment. (c) 2007 Elsevier Inc. All rights reserved.
C1 Univ Cattolica Sacro Cuore, Inst Cardiol, I-00168 Rome, Italy.
C3 Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli
RP Galiuto, L (corresponding author), Univ Cattolica Sacro Cuore, Inst Cardiol, I-00168 Rome, Italy.
EM lgaliuto@rm.unicatt.it
RI Crea, Filippo/AAC-9754-2022; Lanza, Gaetano/AAC-2660-2019; Galiuto,
   Leonarda/AAB-9768-2022; Larosa, Claudio/AAW-4457-2020; Sgueglia,
   Gregory/A-9701-2019; Infusino, Fabio/JEF-6750-2023
OI Sgueglia, Gregory/0000-0001-9680-7412; Infusino,
   Fabio/0000-0001-9287-5936
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NR 13
TC 61
Z9 64
U1 0
U2 3
PU EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010 USA
SN 0002-9149
J9 AM J CARDIOL
JI Am. J. Cardiol.
PD MAY 15
PY 2007
VL 99
IS 10
BP 1378
EP 1383
DI 10.1016/j.amjcard.2006.12.070
PG 6
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 171DU
UT WOS:000246715900007
PM 17493464
DA 2025-06-11
ER

PT J
AU Sullivan, AE
   Courvan, MCS
   Ada, AW
   Wasserman, DH
   Niswender, KD
   Shardelow, EM
   Wells, EK
   Wells, QS
   Freiberg, MS
   Beckman, JA
AF Sullivan, Alexander E.
   Courvan, Meaghan C. S.
   Ada, Aaron W.
   Wasserman, David H.
   Niswender, Kevin D.
   Shardelow, Emily M.
   Wells, Emily K.
   Wells, Quinn S.
   Freiberg, Matthew S.
   Beckman, Joshua A.
TI The Role of Serum Free Fatty Acids in Endothelium-Dependent
   Microvascular Function
SO ENDOCRINOLOGY DIABETES & METABOLISM
LA English
DT Article
DE endothelial function; free fatty acid; insulin-mediated vasodilation;
   insulin sensitivity; metabolic syndrome
ID KINASE C-BETA; INSULIN-RESISTANCE; OXIDATIVE STRESS; ADIPOSE-TISSUE;
   GLUCOSE; VASODILATION; SENSITIVITY; SALSALATE; ACIPIMOX; HYPERGLYCEMIA
AB BackgroundElevated serum free fatty acid (FFA) concentration is associated with insulin resistance and is a hallmark of metabolic syndrome. A pathological feature of insulin resistance is impaired endothelial function.ObjectiveTo investigate the effect of FFA reduction with either acipimox, a nicotinic acid derivative that impairs lipolysis, or salsalate, a salicylate that reduces basal and inflammation-induced lipolysis, on insulin-mediated endothelium-dependent vasodilation.MethodsThis was a post hoc, combined analysis of two randomised, double-blind, placebo-controlled crossover trials. Sixteen subjects were recruited (6 with metabolic syndrome and 10 controls) and randomised to acipimox 250 mg orally every 6 h for 7 days or placebo. Nineteen subjects were recruited (13 with metabolic syndrome and 6 controls) and randomised to receive salsalate 4.5 g/day for 4 weeks or placebo. The primary outcome was the association between FFA concentration and insulin-mediated vasodilation, measured by venous-occlusion strain-gauge plethysmography at baseline and following FFA modulation with the study drugs.ResultsAt baseline, FFA concentration (R = -0.35, p = 0.043) and insulin sensitivity (HOMA-IR: R = -0.42, p = 0.016, Adipo-IR: R = -0.39, p = 0.025) predicted insulin-mediated vasodilation. FFA levels were significantly reduced after drug pretreatment (0.604 vs. 0.491 mmol/L, p = 0.036) while insulin levels, insulin sensitivity and inflammatory markers were unchanged. Despite a reduction in circulating FFA with drug therapy, neither insulin-stimulated vasodilation nor insulin sensitivity improved.ConclusionsShort-term reduction of FFA concentration does not improve insulin-stimulated vasodilation in patients with metabolic syndrome.Trial Registration identifier: NCT00759291 and NCT00760019 (formerly NCT00762827)
C1 [Sullivan, Alexander E.; Ada, Aaron W.; Wells, Emily K.; Wells, Quinn S.; Freiberg, Matthew S.] Vanderbilt Univ, Med Ctr, Dept Med, Div Cardiovasc Med, Nashville, TN USA.
   [Courvan, Meaghan C. S.] Univ Colorado, Dept Biochem, Boulder, CO USA.
   [Ada, Aaron W.; Wells, Emily K.; Wells, Quinn S.] Vanderbilt Univ, Vanderbilt Translat & Clin Cardiovasc Res Ctr, Med Ctr, Div Cardiovasc Med, Nashville, TN USA.
   [Wasserman, David H.] Vanderbilt Univ, Sch Med, Dept Mol Physiol & Biophys, Nashville, TN USA.
   [Niswender, Kevin D.] Vanderbilt Univ, Med Ctr, Dept Med, Nashville, TN USA.
   [Niswender, Kevin D.] Tennessee Valley Healthcare Syst, Dept Vet Affairs, Nashville, TN USA.
   [Shardelow, Emily M.] Vanderbilt Univ, Med Ctr, Program Metab Bone Disorders, Nashville, TN USA.
   [Freiberg, Matthew S.] Vet Affairs Tennessee Valley Healthcare Syst, Geriatr Res Educ & Clin Ctr GRECC, Nashville, TN USA.
   [Beckman, Joshua A.] Univ Texas Southwestern, Dept Med, Div Vasc Med, Dallas, TX 75390 USA.
C3 Vanderbilt University; University of Colorado System; University of
   Colorado Boulder; Vanderbilt University; Vanderbilt University;
   Vanderbilt University; US Department of Veterans Affairs; Veterans
   Health Administration (VHA); VA Tennessee Valley Healthcare System;
   Vanderbilt University; US Department of Veterans Affairs; Veterans
   Health Administration (VHA); VA Tennessee Valley Healthcare System;
   Geriatric Research Education & Clinical Center; University of Texas
   System; University of Texas Southwestern Medical Center Dallas
RP Beckman, JA (corresponding author), Univ Texas Southwestern, Dept Med, Div Vasc Med, Dallas, TX 75390 USA.
EM joshua.beckman@utsouthwestern.edu
RI Freiberg, Matthew/IYJ-5456-2023; Wells, Quinn/D-2686-2014
FU American Diabetes Association
FX The authors have nothing to report.
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NR 40
TC 0
Z9 0
U1 2
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
EI 2398-9238
J9 ENDOCRIN DIAB METAB
JI Endocrinol. Diabetes Metab.
PD MAR
PY 2025
VL 8
IS 2
AR e70031
DI 10.1002/edm2.70031
PG 9
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA U2J7I
UT WOS:001410126300001
PM 39888728
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU King, AC
   Goldberg, JH
   Salmon, J
   Owen, N
   Dunstan, D
   Weber, D
   Doyle, C
   Robinson, TN
AF King, Abby C.
   Goldberg, Jennifer H.
   Salmon, Jo
   Owen, Neville
   Dunstan, David
   Weber, Deanne
   Doyle, Colleen
   Robinson, Thomas N.
TI Identifying Subgroups of US Adults at Risk for Prolonged Television
   Viewing to Inform Program Development
SO AMERICAN JOURNAL OF PREVENTIVE MEDICINE
LA English
DT Article
ID TYPE-2 DIABETES-MELLITUS; PHYSICAL-ACTIVITY; SEDENTARY BEHAVIORS;
   LOGISTIC-REGRESSION; METABOLIC SYNDROME; TIME; OBESITY; INTERVENTION;
   ENVIRONMENTS; ASSOCIATIONS
AB Background: Although adverse health effects of prolonged TV viewing have been increasingly recognized, little population-wide information is available concerning subgroups at greatest risk for this behavior.
   Purpose: This study sought to identify, in a U.S. population-derived sample, combinations of variables that defined subgroups with higher versus lower levels of usual TV-viewing time.
   Methods: A total of 5556 adults from a national consumer panel participated in the mail survey in 2001 (55% women, 71% white, 13% black, and 11% Hispanic). Nonparametric risk classification analyses were conducted in 2008.
   Results: Subgroups with the highest proportions of people watching > 14hours/week of TV were identified and described using a combination of demographic (i.e., lower household incomes, divorced/separated); health and mental health (i.e., poorer rated overall health, higher BMI, more depression); and behavioral (i.e., eating dinner in front of the TV, smoking, less physical activity) variables. The subgroup with the highest rates of TV viewing routinely ate dinner while watching TV and had lower income and poorer health. Prolonged TV viewing also was associated with perceived aspects of the neighborhood environment (i.e., heavy traffic and crime, lack of neighborhood lighting, and poor scenery).
   Conclusions: The results can help inform intervention development in this increasingly important behavioral health area. (Am J Prev Med 2010;38(1):17-26) (C) 2010 American Journal of Preventive Medicine
C1 [King, Abby C.] Stanford Univ, Sch Med, Dept Hlth Res & Policy, Div Epidemiol, Stanford, CA 94305 USA.
   [King, Abby C.; Goldberg, Jennifer H.; Robinson, Thomas N.] Stanford Univ, Sch Med, Stanford Ctr Res Dis Prevent, Dept Med, Stanford, CA 94305 USA.
   [Robinson, Thomas N.] Stanford Univ, Sch Med, Dept Pediat, Div Gen Pediat, Stanford, CA 94305 USA.
   [Salmon, Jo] Deakin Univ, Sch Exercise & Nutr Sci, Ctr Phys Act & Nutr Res, Melbourne, Vic, Australia.
   [Dunstan, David] Baker IDI Heart & Diabet Inst, Melbourne, Vic, Australia.
   [Owen, Neville] Univ Queensland, Sch Populat Hlth, Canc Prevent Res Ctr, Brisbane, Qld, Australia.
   [Weber, Deanne] Porter Novelli, Gainesville, FL USA.
   [Doyle, Colleen] Amer Canc Soc, Atlanta, GA 30329 USA.
C3 Stanford University; Stanford University; Stanford University; Deakin
   University; Baker Heart and Diabetes Institute; University of
   Queensland; American Cancer Society
RP King, AC (corresponding author), Stanford Univ, Sch Med, Dept Hlth Res & Policy, Div Epidemiol, 259 Campus Dr,HRP Redwood Bldg,T221, Stanford, CA 94305 USA.
EM king@stanford.edu
RI Salmon, Jo/X-2630-2019; King, Abby/AAD-5257-2021; Owen,
   Neville/IXN-9070-2023; Salmon, Jo/C-1226-2009; Dunstan,
   David/E-8473-2010; Owen, Neville/K-5986-2012
OI Salmon, Jo/0000-0002-4734-6354; Robinson, Thomas/0000-0002-2367-0774;
   Dunstan, David/0000-0003-2629-9568; Owen, Neville/0000-0003-2784-4820;
   King, Abby/0000-0002-7949-8811
FU NIH, National Heart, Lung, and Blood Institute [HL077141]; National
   Cancer Institute [CA 127511]; National Heart Foundation of Australia;
   Queensland Health; National Health and Medical Research Council of
   Australia [301200]
FX The American Cancer Society provided funding for the original data
   collection. The authors wish to thank Drs. Ken Resnicow, Tom Baranowski,
   and Russell Pate who, along with Dr. King, provided expertise related to
   the development of the survey. Dr. King is supported in part by grants
   received from the NIH, National Heart, Lung, and Blood Institute
   (HL077141), and the National Cancer Institute (CA 127511). Dr. Salmon is
   supported by a National Heart Foundation of Australia Career Development
   Award and sanofi-aventis. Dr. Owen is supported by a Research
   Infrastructure Grant from Queensland Health and by a Program Grant
   (301200) from the National Health and Medical Research Council of
   Australia.
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   ZERHOUNI EA, NIMH COUNC M SEP 200
NR 48
TC 56
Z9 60
U1 0
U2 15
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0749-3797
EI 1873-2607
J9 AM J PREV MED
JI Am. J. Prev. Med.
PD JAN
PY 2010
VL 38
IS 1
BP 17
EP 26
DI 10.1016/j.amepre.2009.08.032
PG 10
WC Public, Environmental & Occupational Health; Medicine, General &
   Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; General & Internal Medicine
GA 541KL
UT WOS:000273413800003
PM 20117553
DA 2025-06-11
ER

PT J
AU Looijmans, A
   Jörg, F
   Bruggeman, R
   Schoevers, RA
   Corpeleijn, E
   Feenstra, TL
   van Asselt, ADI
AF Looijmans, Anne
   Jorg, Frederike
   Bruggeman, Richard
   Schoevers, Robert A.
   Corpeleijn, Eva
   Feenstra, Talitha L.
   van Asselt, A. D. I. (Thea)
TI Cost-effectiveness and budget impact of a lifestyle intervention to
   improve cardiometabolic health in patients with severe mental illness
SO GLOBAL & REGIONAL HEALTH TECHNOLOGY ASSESSMENT
LA English
DT Article
DE Budget impact analysis; Cardiometabolic risk; Cost-effectiveness;
   Lifestyle intervention; Mental health care; Severe mental illnesses
ID WEIGHT-LOSS; INDIVIDUALS; MEDICATIONS
AB Introduction: This study assessed the cost-effectiveness and budget impact of a lifestyle intervention to improve cardiometabolic health in severe mentally ill (SMI) patients in the LION trial.
   Methods: Patients (n = 244) were randomized to receive either care-as-usual or a lifestyle intervention in which mental health nurses coached patients in changing their lifestyle by using a web tool. Costs and quality of life were assessed at baseline and at 6 and 12 months. Incremental costs per centimeter waist circumference (WC) lost and per Quality-Adjusted Life Year (QALY) gained were assessed. Budget impact was estimated based on three intervention-uptake scenarios using a societal and a third-party payer perspective.
   Results: Costs and reduction in WC were higher in the intervention (n = 114) than in the control (n = 94) group after 12 months, although not statistically significant, resulting in (sic)1,370 per cm WC lost. QALYs did not differ between the groups, resulting in a low probability of the intervention being cost-effective in cost/QALY gained. The budget impact analysis showed that for a reasonable participation of 43%, total costs were around (sic)81 million over 5 years, or on average (sic)16 million annually (societal perspective).
   Conclusions: The intervention is not cost-effective at 12 months and the budget impact over 5 years is substantial. Possibly, 12 months was too short to implement the intervention, improve cardiometabolic health, and reduce care costs. Therefore, the incentive for this intervention cannot be found in short-term financial advantages. However, there may be benefits associated with lifestyle interventions in the long term that remain unclear.
C1 [Looijmans, Anne] Univ Groningen, Univ Med Ctr Groningen, Dept Hlth Psychol, Groningen, Netherlands.
   [Looijmans, Anne; Jorg, Frederike; Bruggeman, Richard] Univ Groningen, Univ Med Ctr Groningen, Rob Giel Res Ctr, Groningen, Netherlands.
   [Jorg, Frederike] Friesland Mental Hlth Serv, Res Dept, Leeuwarden, Netherlands.
   [Bruggeman, Richard; Schoevers, Robert A.] Univ Groningen, Univ Med Ctr Groningen, Dept Psychiat, Groningen, Netherlands.
   [Corpeleijn, Eva; Feenstra, Talitha L.; van Asselt, A. D. I. (Thea)] Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, Groningen, Netherlands.
   [Feenstra, Talitha L.] Univ Groningen, Groningen Res Inst Pharm, Fac Sci & Engn, Groningen, Netherlands.
   [Feenstra, Talitha L.] Natl Inst Publ Hlth & Environm RIVM, Bilthoven, Netherlands.
   [van Asselt, A. D. I. (Thea)] Univ Groningen, Univ Med Ctr Groningen, Dept Hlth Sci, Groningen, Netherlands.
C3 University of Groningen; University of Groningen; University of
   Groningen; University of Groningen; University of Groningen; Netherlands
   National Institute for Public Health & the Environment; University of
   Groningen
RP Looijmans, A (corresponding author), Univ Med Ctr Groningen, Dept Hlth Psychol, Hanzepl 1,POB 30-001, NL-9700 RB Groningen, Netherlands.
EM A.Looijmans@umcg.nl
RI Jörg, Frederike/B-1325-2014; Feenstra, Talitha/AAM-3234-2020
OI van Asselt, Antoinette/0000-0001-7705-9906; Corpeleijn,
   Eva/0000-0002-2974-3305; Schoevers, Robert A/0000-0003-0760-9866
FU ZonMw [837001006]
FX This work was supported by ZonMw (grant number 837001006). The funding
   source had no influence on the study design; in the collection,
   analysis, and interpretation of the data; in the writing of the report;
   and in the decision to submit the paper for publication.
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NR 29
TC 3
Z9 3
U1 0
U2 0
PU ABOUTSCIENCE SRL
PI MILAN
PA PIAZZA DUCA D AOSTA,  12, MILAN, MI, ITALY
SN 2284-2403
EI 2283-5733
J9 GLOB REG HEALTH TECH
JI Glob. Reg. Health Technol. Assess.
PD JAN
PY 2020
VL 7
IS 1
BP 131
EP 138
DI 10.33393/grhta.2020.2027
PG 8
WC Health Care Sciences & Services
WE Emerging Sources Citation Index (ESCI)
SC Health Care Sciences & Services
GA PH4SZ
UT WOS:000600405800001
PM 36627968
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Cleland, VJ
   Schmidt, MD
   Salmon, J
   Dwyer, T
   Venn, A
AF Cleland, Verity J.
   Schmidt, Michael D.
   Salmon, Jo
   Dwyer, Terence
   Venn, Alison
TI Correlates of pedometer-measured and self-reported physical activity
   among young Australian adults
SO JOURNAL OF SCIENCE AND MEDICINE IN SPORT
LA English
DT Article
DE Motor activity; Epidemiologic factors; Cross-sectional studies;
   Pedometer; Questionnaire
ID CARDIOMETABOLIC RISK; ABDOMINAL OBESITY; FOOD-CONSUMPTION;
   PUBLIC-HEALTH; DIET QUALITY; ASSOCIATIONS; RECOMMENDATION; RELIABILITY;
   FITNESS; WEIGHT
AB Accurately quantifying physical activity is important for investigating relations with potential correlates, but past studies have mostly relied on self-report measures, which may be susceptible to error and biases, limiting interpretability. This study aimed to examine correlates of pedometer-determined physical activity and compare them with correlates of self-reported physical activity. Cross-sectional data were taken from 2017 Australian adults (aged 26-36 years) who were involved in the Childhood Determinants of Adult Health follow-up study during 2004-2006. Daily steps were recorded for seven days using Yamax pedometers and physical activity (total min/week) was reported via the long International Physical Activity Questionnaire. Demographic, biological, behavioral, psychological, social and environmental factors were assessed. Lower education, blue collar occupation and higher mental health score (men) and low-moderate alcohol intake (women) were positively associated with self-report and pedometer-measured activity. Among men, body mass index (BMI) was inversely and physical health score was positively associated with pedometer-measured activity while smoking, low to moderate alcohol intake, higher general health and urban area of residence were positively associated with self-reported activity. Among women, age and general health status were positively associated and number of live births inversely associated with pedometer-measured activity, while lower education, blue collar occupation, part time employment, smoking, diet, higher physical health score and higher mental health score were positively associated and white collar occupation inversely associated with self-reported activity. Many physical activity correlates differed depending on the measure employed; researchers should be mindful of these differences when selecting measures of physical activity. (C) 2011 Sports Medicine Australia. Published by Elsevier Ltd. All rights reserved.
C1 [Cleland, Verity J.; Salmon, Jo] Deakin Univ, Ctr Phys Act & Nutr Res, Geelong, Vic 3217, Australia.
   [Cleland, Verity J.; Schmidt, Michael D.; Venn, Alison] Univ Tasmania, Menzies Res Inst Tasmania, Hobart, Tas 7001, Australia.
   [Schmidt, Michael D.] Univ Georgia, Dept Kinesiol, Athens, GA 30602 USA.
C3 Deakin University; University of Tasmania; University System of Georgia;
   University of Georgia
RP Cleland, VJ (corresponding author), Deakin Univ, Ctr Phys Act & Nutr Res, Geelong, Vic 3217, Australia.
EM verity.cleland@utas.edu.au
RI Venn, Alison/J-2803-2013; Salmon, Jo/X-2630-2019; Cleland,
   Verity/J-7677-2014; Salmon, Jo/C-1226-2009
OI Cleland, Verity/0000-0001-8358-3237; Schmidt, Michael
   D/0000-0002-8062-4491; Salmon, Jo/0000-0002-4734-6354
FU National Health and Medical Research Council; National Heart Foundation;
   Tasmanian Community Fund; Veolia Environmental Services; Sanitarium;
   ASICS; Target; National Health Foundation (Australia) [PH 06H 2817];
   National Heart Foundation of Australia
FX This study was funded by the National Health and Medical Research
   Council, the National Heart Foundation, the Tasmanian Community Fund and
   Veolia Environmental Services. The study was sponsored by Sanitarium,
   ASICS and Target. The authors gratefully acknowledge the contributions
   of the project manager Ms. Marita Dalton, all project staff and
   volunteers, and the study participants. VC is supported by a National
   Health and Medical Research Council Public Health Training
   (Postdoctoral) Fellowship. MS was supported by a National Health
   Foundation (Australia) Postdoctoral Fellowship (PH 06H 2817). JS is
   supported by a National Heart Foundation of Australia Career Development
   Award.
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NR 36
TC 24
Z9 26
U1 0
U2 18
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1440-2440
EI 1878-1861
J9 J SCI MED SPORT
JI J. Sci. Med. Sport
PD NOV
PY 2011
VL 14
IS 6
BP 496
EP 503
DI 10.1016/j.jsams.2011.04.006
PG 8
WC Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Sport Sciences
GA 852VZ
UT WOS:000297386900007
PM 21622024
DA 2025-06-11
ER

PT J
AU Thomaz, FS
   John, OD
   Sinha, P
   Shafie, SR
   Worrall, S
AF Thomaz, Fernanda Santos
   John, Oliver Dean
   Sinha, Payel
   Shafie, Siti Raihanah
   Worrall, Simon
TI The Metabolic Syndrome: An Overview and Proposed Mechanisms
SO OBESITIES
LA English
DT Review
DE obesity; metabolic syndrome; type 2 diabetes; hypertension
ID NITRIC-OXIDE SYNTHASE; ENDOPLASMIC-RETICULUM STRESS; ELEMENT-BINDING
   PROTEIN; GLUCAGON-LIKE PEPTIDE-1; ADIPOSE-TISSUE; INSULIN-RESISTANCE;
   PYRUVATE-CARBOXYLASE; ENDOTHELIAL-CELLS; GLUCOSE-HOMEOSTASIS;
   ELECTRON-TRANSFER
AB Obesity has emerged as a major public health challenge in the 21st century, contributing to the rising prevalence of metabolic syndrome (MetS), a cluster of interrelated health risk factors. These factors include obesity or abdominal obesity, type 2 diabetes mellitus (T2DM), hypertension (HTN), and dyslipidaemia. In this review, we will explore important aspects of metabolic regulation and the dynamics of lipoprotein metabolism to see how they underlie each of these major health risks. Additionally, we will highlight the role of ferroptosis, an iron-dependent regulated cell death process, in relation to inflammatory responses and its critical contribution to the pathophysiology of MetS. These inflammatory responses include inflammasome activation, lipotoxicity, the influence of adipocytokines, and the role of adipose tissue macrophages. By exploring these interconnections, this review aims to provide insights into metabolic crosstalk, outline the pathological mechanisms occurring, and identify potential therapeutic targets for managing and preventing the progression of these health risk factors.
C1 [Thomaz, Fernanda Santos; Worrall, Simon] Univ Queensland, Sch Chem & Mol Biosci, St Lucia, Qld 4067, Australia.
   [John, Oliver Dean] Asia Pacific Int Univ, Fac Sci, Muak Lek 18180, Saraburi, Thailand.
   [Sinha, Payel] Univ Southern Queensland, Ctr Agr Engn, Toowoomba, Qld 4350, Australia.
   [Shafie, Siti Raihanah] Univ Putra Malaysia, Fac Med & Hlth Sci, Serdang 43400, Malaysia.
C3 University of Queensland; University of Southern Queensland; Universiti
   Putra Malaysia
RP Thomaz, FS (corresponding author), Univ Queensland, Sch Chem & Mol Biosci, St Lucia, Qld 4067, Australia.
EM fernanda.thomaz@uq.net.au; oliverdjohn@outlook.com;
   payel.sinha@usq.edu.au; sitiraihanah@upm.edu.my; s.worrall@uq.edu.au
RI John, Oliver/AAX-5651-2021; Shafie, Siti/AAJ-3033-2020; Worrall,
   Simon/A-4841-2010; Shafie, Siti/G-1959-2017
OI Shafie, Siti/0000-0003-2983-7536; John, Oliver Dean/0000-0001-5035-1878
FX This research received no external funding.
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NR 289
TC 3
Z9 3
U1 5
U2 7
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2673-4168
J9 OBESITIES-BASEL
JI Obesities
PD SEP
PY 2024
VL 4
IS 3
BP 226
EP 255
DI 10.3390/obesities4030020
PG 30
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA H5T1L
UT WOS:001324054600001
OA gold
DA 2025-06-11
ER

PT J
AU Abdelhaffez, AS
   Abd El-Aziz, EA
   Tohamy, MB
   Ahmed, AM
AF Abdelhaffez, Azza S.
   Abd El-Aziz, Ebtihal A.
   Tohamy, Maha B.
   Ahmed, Asmaa M.
TI N-acetyl cysteine can blunt metabolic and cardiovascular effects via
   down-regulation of cardiotrophin-1 in rat model of fructose-induced
   metabolic syndrome
SO ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
LA English
DT Article
DE Metabolic syndrome; N-acetyl cysteine; cardiotrophin-1; heart; aorta
AB In this study, we investigated the ability of N-acetyl cysteine (NAC) to alleviate the metabolic disorders in fructose-induced metabolic syndrome (MS) in male rats and to examine its protective effect on aortic and cardiac tissues via its influence on cardiotrophin-1 (CT-1) expression. NAC (20 mg/kg b.w./day) was administered to fructose induced MS animals for 12 weeks. Chronic fructose consumption (20% w/v) increased body weight gain, relative heart weight, systolic blood pressure (SBP), diastolic blood pressure (DBP), insulin resistance (IR), and associated with metabolic alterations. Histological and immunohistochemical examination revealed aortic stiffness and myocardial degeneration and fibrosis together with increased CT-1 expression. Treatment with NAC improved IR, SBP, DBP, and mitigated dyslipidaemia and oxidative stress. Additionally, NAC down-regulated CT-1 expression in the heart and aorta. These findings demonstrated the protective effect of NAC against aortic and myocardial degeneration and fibrosis through down-regulation of CT-1 in fructose induced MS animal model.
C1 [Abdelhaffez, Azza S.; Abd El-Aziz, Ebtihal A.; Tohamy, Maha B.] Assiut Univ, Fac Med, Dept Med Physiol, Assiut, Egypt.
   [Ahmed, Asmaa M.] Assiut Univ, Fac Med, Dept Pathol, Assiut, Egypt.
C3 Egyptian Knowledge Bank (EKB); Assiut University; Egyptian Knowledge
   Bank (EKB); Assiut University
RP Abdelhaffez, AS (corresponding author), Assiut Univ, Fac Med, Dept Med Physiol, Assiut, Egypt.
EM azza@aun.edu.eg
OI Abdelhaffez, Azza/0000-0003-1567-7041
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NR 83
TC 5
Z9 5
U1 0
U2 8
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1381-3455
EI 1744-4160
J9 ARCH PHYSIOL BIOCHEM
JI Arch. Physiol. Biochem.
PD JUL 4
PY 2023
VL 129
IS 4
BP 854
EP 869
DI 10.1080/13813455.2021.1876735
EA JAN 2021
PG 16
WC Biochemistry & Molecular Biology; Biophysics; Endocrinology &
   Metabolism; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Endocrinology &
   Metabolism; Physiology
GA M6RE8
UT WOS:000612773900001
PM 33507837
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Siegel, G
   Ermilov, E
   Knes, O
   Rodríguez, M
AF Siegel, G.
   Ermilov, E.
   Knes, O.
   Rodriguez, M.
TI Combined lowering of low grade systemic inflammation and insulin
   resistance in metabolic syndrome patients treated with Ginkgo
   biloba
SO ATHEROSCLEROSIS
LA English
DT Article
DE Metabolic syndrome patients; High-sensitivity C-reactive protein
   (hs-CRP); Homeostasis model assessment of insulin resistance (HOMA-IR);
   CVD/total mortality risk; Ginkgo biloba
ID C-REACTIVE PROTEIN; CARDIOVASCULAR EVENTS; PREDICTS MORTALITY; HS-CRP;
   RISK; ATHEROSCLEROSIS; INTERLEUKIN-6; INDIVIDUALS; POPULATION; REDUCTION
AB In a clinical pilot study with eleven metabolic syndrome patients, a simultaneous decrease in hs-CRP from 8.85 +/- 4.09 to 4.92 +/- 2.51 mg/L (-44.4%) (p < 0.0436) and HOMA-IR from 3.07 +/- 0.63 to 2.60 +/- 0.51 mU/L x mg/dL (-15.3%) (p < 0.0120) as well as a beneficial change of arteriosclerotic, inflammatory and oxidative stress biomarkers were detected after 2-month treatment with Ginkgo biloba. Furthermore, both IL-6 (-12.9%, p < 0.0407) and nanoplaque formation (-14.3%, p < 0.0077) were additionally reduced. According to a large clinical trial elucidating the importance of insulin resistance and low-grade systemic inflammation for cardiovascular disease and overall mortality risk, these data might indicate a CVD/total mortality risk reduction. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
C1 [Siegel, G.; Ermilov, E.; Rodriguez, M.] Charite, D-10117 Berlin, Germany.
   [Siegel, G.] Uppsala Univ, Biomed Ctr, S-75123 Uppsala, Sweden.
   [Knes, O.] Swiss Anal AG, CH-8274 Tagerwilen, Switzerland.
   [Rodriguez, M.] Scienion AG, D-12489 Berlin, Germany.
C3 Berlin Institute of Health; Free University of Berlin; Humboldt
   University of Berlin; Charite Universitatsmedizin Berlin; Uppsala
   University; Cellink
RP Siegel, G (corresponding author), Charite, Inst Physiol, Charite Pl 1, D-10117 Berlin, Germany.
EM guenter.siegel@charite.de
OI Ermilov, Eugeny/0000-0003-3679-9996; Knes, Otto/0000-0002-1982-403X
FU Schwabe Pharmaceuticals, Karlsruhe, Germany
FX This clinical trial was supported by a modest research grant by Schwabe
   Pharmaceuticals, Karlsruhe, Germany to G.S.
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NR 37
TC 19
Z9 20
U1 0
U2 11
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0021-9150
EI 1879-1484
J9 ATHEROSCLEROSIS
JI Atherosclerosis
PD DEC
PY 2014
VL 237
IS 2
BP 584
EP 588
DI 10.1016/j.atherosclerosis.2014.10.023
PG 5
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA AW1RG
UT WOS:000346066600061
PM 25463092
DA 2025-06-11
ER

PT J
AU Zhang, SY
   Xu, MY
   Zhang, WX
   Liu, C
   Chen, SY
AF Zhang, Shiyao
   Xu, Mengyi
   Zhang, Wenxiang
   Liu, Chang
   Chen, Siyu
TI Natural Polyphenols in Metabolic Syndrome: Protective Mechanisms and
   Clinical Applications
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE metabolic syndrome; natural polyphenol; protective effect; application
ID FATTY LIVER-DISEASE; BETA-D-GLUCOSE; NF-KAPPA-B; IMPROVES
   INSULIN-RESISTANCE; CARDIOVASCULAR RISK-FACTORS;
   ESTROGEN-RECEPTOR-ALPHA; TYPE-2 DIABETIC-RATS; DIET-INDUCED OBESITY;
   DOUBLE-BLIND; GALLIC ACID
AB Metabolic syndrome (MetS) is a chronic disease, including abdominal obesity, dyslipidemia, hyperglycemia, and hypertension. It should be noted that the occurrence of MetS is closely related to oxidative stress-induced mitochondrial dysfunction, ectopic fat accumulation, and the impairment of the antioxidant system, which in turn further aggravates the intracellular oxidative imbalance and inflammatory response. As enriched anti-inflammatory and antioxidant components in plants, natural polyphenols exhibit beneficial effects, including improving liver fat accumulation and dyslipidemia, reducing blood pressure. Hence, they are expected to be useful in the prevention and management of MetS. At present, epidemiological studies indicate a negative correlation between polyphenol intake and MetS incidence. In this review, we summarized and discussed the most promising natural polyphenols (including flavonoid and non-flavonoid drugs) in the precaution and treatment of MetS, including their anti-inflammatory and antioxidant properties, as well as their regulatory functions involved in glycolipid homeostasis.
C1 [Zhang, Shiyao; Xu, Mengyi; Zhang, Wenxiang; Liu, Chang; Chen, Siyu] China Pharmaceut Univ, State Key Lab Nat Med, Nanjing 211198, Peoples R China.
   [Zhang, Shiyao; Xu, Mengyi; Zhang, Wenxiang; Liu, Chang; Chen, Siyu] China Pharmaceut Univ, Sch Life Sci & Technol, Nanjing 211198, Peoples R China.
C3 China Pharmaceutical University; China Pharmaceutical University
RP Chen, SY (corresponding author), China Pharmaceut Univ, State Key Lab Nat Med, Nanjing 211198, Peoples R China.
EM 3119030138@stu.cpu.edu.cn; 1821030605@stu.cpu.edu.cn;
   wenxiangzhang@cpu.edu.cn; changliu@cpu.edu.cn; siyuchen@cpu.edu.cn
RI Zhang, Shi-yao/GRO-1062-2022; Zhang, Wenxiang/HZK-0191-2023
OI Liu, Chang/0000-0001-9251-708X; Chen, Siyu/0000-0002-3809-1062; Zhang,
   Shiyao/0000-0001-8871-0215; Zhang, Wenxiang/0000-0002-1077-8014
FU National Natural Science Foundation of China [31800992, 92057112,
   31771298, 81800512]; Natural Science Foundation of Jiangsu Province
   [BK20180554, BK20180577]; Priority Academic Program Development of
   Jiangsu Higher Education Institutions (PAPD)
FX This work was financially supported by grants from the National Natural
   Science Foundation of China (grant no. 31800992 to S.Y.C., 92057112 and
   31771298 to C.L., 81800512 toW.X.Z.), the Natural Science Foundation of
   Jiangsu Province (grant no. BK20180554 to S.Y.C., BK20180577 to W.X.Z.),
   and the Priority Academic Program Development of Jiangsu Higher
   Education Institutions (PAPD, to S.Y.C. and C.L.).
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NR 274
TC 48
Z9 53
U1 5
U2 49
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD JUN
PY 2021
VL 22
IS 11
AR 6110
DI 10.3390/ijms22116110
PG 34
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA SQ1RI
UT WOS:000660136600001
PM 34204038
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Nasrallah, R
   Hassouneh, R
   Hébert, RL
AF Nasrallah, Rania
   Hassouneh, Ramzi
   Hebert, Richard L.
TI PGE2, Kidney Disease, and Cardiovascular Risk: Beyond
   Hypertension and Diabetes
SO JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
LA English
DT Review
ID NONSTEROIDAL ANTIINFLAMMATORY DRUGS; SALT-SENSITIVE HYPERTENSION;
   PROSTAGLANDIN E-2 RECEPTORS; SUPPRESS VLDL SECRETION; EP4 RECEPTOR;
   BLOOD-PRESSURE; RENAL INJURY; MICE LACKING; PPAR-GAMMA; CYCLOOXYGENASE-2
   INHIBITION
AB An important measure of cardiovascular health is obtained by evaluating the global cardiovascular risk, which comprises a number of factors, including hypertension and type 2 diabetes, the leading causes of illness and death in the world, as well as the metabolic syndrome. Altered immunity, inflammation, and oxidative stress underlie many of the changes associated with cardiovascular disease, diabetes, and the metabolic syndrome, and recent efforts have begun to elucidate the contribution of PGE(2) in these events. This review summarizes the role of PGE(2) in kidney disease outcomes that accelerate cardiovascular disease, highlights the role of cyclooxygenase-2/microsomal PGE synthase 1/PGE(2) signaling in hypertension and diabetes, and outlines the contribution of PGE(2) to other aspects of the metabolic syndrome, particularly abdominal adiposity, dyslipidemia, and atherogenesis. A clearer understanding of the role of PGE(2) could lead to new avenues to improve therapeutic options and disease management strategies.
C1 [Nasrallah, Rania; Hassouneh, Ramzi; Hebert, Richard L.] Univ Ottawa, Fac Med, Kidney Res Ctr, Dept Cellular & Mol Med, 451 Smyth Rd,Room 2514, Ottawa, ON K1H 8M5, Canada.
C3 University of Ottawa; Ottawa Hospital Research Institute
RP Hébert, RL (corresponding author), Univ Ottawa, Fac Med, Kidney Res Ctr, Dept Cellular & Mol Med, 451 Smyth Rd,Room 2514, Ottawa, ON K1H 8M5, Canada.
EM rlhebert@uottawa.ca
FU Canadian Institutes of Health Research, (Ottawa, Ontario, Canada);
   Kidney Foundation of Canada (Montreal, Quebec, Canada)
FX Financial support was provided by the Canadian Institutes of Health
   Research, (Ottawa, Ontario, Canada) and The Kidney Foundation of Canada
   (Montreal, Quebec, Canada).
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NR 136
TC 79
Z9 89
U1 0
U2 22
PU AMER SOC NEPHROLOGY
PI WASHINGTON
PA 1725 I ST, NW STE 510, WASHINGTON, DC 20006 USA
SN 1046-6673
EI 1533-3450
J9 J AM SOC NEPHROL
JI J. Am. Soc. Nephrol.
PD MAR
PY 2016
VL 27
IS 3
BP 666
EP 676
DI 10.1681/ASN.2015050528
PG 11
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA DF1LN
UT WOS:000371101400005
PM 26319242
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Andishmand, A
   Ansari, Z
   Soltani, MH
   Mirshamsi, H
   Raafat, S
AF Andishmand, A.
   Ansari, Z.
   Soltani, M. H.
   Mirshamsi, H.
   Raafat, S.
TI Vitamin D replacement therapy in patients with cardiac syndrome X
SO PERFUSION-UK
LA English
DT Article
DE cardiac syndrome X; vitamin D; replacement therapy; vitamin D
   deficiency; ischemia
ID CONVERTING ENZYME-INHIBITORS; NORMAL CORONARY ANGIOGRAMS;
   SMOOTH-MUSCLE-CELLS; NITRIC-OXIDE; ENDOTHELIAL DYSFUNCTION; ANGINA;
   MECHANISMS; ARTERIES; DISEASE
AB Aims: The aim of present study was to assess whether vitamin D, with proven beneficial effects on the cardiovascular system, has any effect on angina and exercise-induced ischemia in patients with cardiac syndrome X and low serum vitamin D.
   Methods: Patients with cardiac syndrome X and low serum vitamin D3 were studied before and after treatment with an intramuscular injection of vitamin D3 (300,000 units, every other week for 2 months). We determined the angina episode (per day) and several indices of exercise capacity.
   Results: At the end of the treatment course (756 day), a significant increase of serum vitamin D3 occurred and was within the normal range (45 +/- 8 ng/ml) and the frequency of angina improved significantly (p=0.003). Exercise duration and maximal work capacity increased significantly (p<0.001). Maximal ST-segment depression (mm) decreased significantly (p=0.001). The calculated Duck treadmill score improved significantly (p=0.001).
   Conclusions: Our findings show that vitamin D replacement therapy in patients with cardiac syndrome X and vitamin D deficiency dramatically improves symptoms and signs of ischemia.
C1 [Andishmand, A.; Ansari, Z.; Soltani, M. H.; Mirshamsi, H.; Raafat, S.] Shahid Sadoughi Univ Med Sci, Afshar Hosp, Cardiovascular Res Ctr, Yazd, Iran.
C3 Shahid Sadoughi University of Medical Sciences
RP Mirshamsi, H (corresponding author), Afshar Hosp, Cardiovasc Dept, Jomhoori Blvd, Yazd 8917945556, Iran.
EM mirshamsih@yahoo.com
RI Andishmand, Abbas/AAT-2412-2021; Soltani, Mohammad/B-1849-2019
FU Research of Shahid Sadouqi Medical University of Yazd
FX This work was supported in part by the Vice Chancellor for Research of
   Shahid Sadouqi Medical University of Yazd.
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NR 17
TC 5
Z9 5
U1 0
U2 1
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0267-6591
EI 1477-111X
J9 PERFUSION-UK
JI Perfusion-UK
PD JAN
PY 2015
VL 30
IS 1
BP 60
EP 63
DI 10.1177/0267659114526629
PG 4
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA AX4SB
UT WOS:000346920500014
PM 24722851
DA 2025-06-11
ER

PT J
AU Becarevic, M
   Barakovic, F
   Burgic, E
AF Becarevic, Munevera
   Barakovic, Fahir
   Burgic, Esad
TI Combination of depression and cardiovascular risk factors in pit miners
SO HEALTHMED
LA English
DT Article
DE depression; pit miners; cardiovascular risk; metabolical syndrome
ID CORONARY-HEART-DISEASE; ACUTE MYOCARDIAL-INFARCTION; TYPE-2
   DIABETES-MELLITUS; METABOLIC SYNDROME; ARTERY-DISEASE; BLOOD-PRESSURE;
   YOUNG-ADULTS; MORTALITY; SYMPTOMS; EPIDEMIOLOGY
AB Cardiovascular disseases and metabilocal szn-drome have shown connection with depression, which is often health problem (1). The aim of research is to determine depression prevalence in Banovici coal mine pit miners and depression influence on total cardiovascular risk.
   Materials and methods: epidemiologial study performed included 492 employees in pit mine department of coal mine Banovici. According to Becks' scale a depression score was determined, the blood preasure value was taken along with height and weight, BMI, weist, total cholesterol concentration, HDL and LDL cholesterol, triglicerids, sugar in blood and smoking status. According to NCEP ATP III criteria, metabolical syndrome was defined. Results: out of 492 testers 34,34 % were with depression, all measured risk factors excluding the weist values were more evident in pit miners with depression. Significant statistical difference was evident in age, smoking status and blood preasure values in pit miners with depression. Metabolical syndrome was evident in 44,97% of pit miners wtih depression along with increased total cardiovascular risk (4 (0-20), p=0,0001.
   Conclusion: the high risk prevalence of depression diagnosing is evident with expressed tendency of risk factor grouping, higher metabolical sndrome presence and higher total cardiovascular risk among tested pit miners.
C1 [Becarevic, Munevera] Publ Hlth Ctr Banovici, Dept Occupat Med, Banovici, Bosnia & Herceg.
   [Barakovic, Fahir] Univrs & Clin Ctr Tuzla, Internal Disseases Clin, Tuzla, Bosnia & Herceg.
   [Burgic, Esad] Publ Hlth Ctr Lukavac, Clin Internal Disseases, Biochem Hematol Lab, Dept Lab Diagnost, Lukavac, Bosnia & Herceg.
RP Becarevic, M (corresponding author), Publ Hlth Ctr Banovici, Dept Occupat Med, Banovici, Bosnia & Herceg.
EM munevera.b@gmail.com
RI Cools, Frank/HSF-6823-2023
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NR 71
TC 0
Z9 0
U1 1
U2 12
PU DRUNPP-SARAJEVO
PI SARAJEVO
PA BOLNICKA BB, SARAJEVO, 71000, BOSNIA & HERCEG
SN 1840-2291
EI 1986-8103
J9 HEALTHMED
JI HealthMED
PY 2012
VL 6
IS 4
BP 1474
EP 1484
PG 11
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 945TX
UT WOS:000304300200060
DA 2025-06-11
ER

PT J
AU Chuang, CS
   Yang, TY
   Muo, CH
   Su, HL
   Sung, FC
   Kao, CH
AF Chuang, Chieh-Sen
   Yang, Tse-Yen
   Muo, Chih-Hsin
   Su, Hong-Lin
   Sung, Fung-Chang
   Kao, Chia-Hung
TI Hyperlipidemia, statin use and the risk of developing depression: a
   nationwide retrospective cohort study
SO GENERAL HOSPITAL PSYCHIATRY
LA English
DT Article
DE Depression; Hyperlipidemia; Statins; National Health Insurance Research
   Database (NHIRD)
ID VASCULAR DEPRESSION; METABOLIC SYNDROME; MAJOR DEPRESSION; LIPID-LEVELS;
   INFLAMMATION; ATHEROSCLEROSIS; SYMPTOMS; DISEASE; HYPERCHOLESTEROLEMIA;
   DYSLIPIDEMIA
AB Objective: Depression is a highly prevalent disorder that is associated with disability. The aim of this study was to determine the relationship between depression and hyperlipidemia and whether the onset of depression is associated with administering statins to patients with hyperlipidemia.
   Material and Methods: The data analyzed in this study were retrieved from the National Health Insurance Research Database in Taiwan. We identified newly diagnosed hyperlipidemia in 26,852 patients without a history of depression as the exposure group in the period of 2000-2002, and a comparison group comprised 107,408 patients. The differences between the exposure group and the comparison group were examined using a chi-square test to calculate categorical variables. The hazard ratio and the 95% confidence interval for depression were used in the logistic regression.
   Results: The hyperlipidemia patients demonstrated a high risk for depression and comorbidities, such as hypertension, diabetes and sleep disorder, which indicated synergistic effects related to a high risk of depression in hyperlipidemia patients. Hyperlipidemia patients who had received statins exhibited a lower risk of depression than did those who had not received statins.
   Conclusion: Our results suggested that hyperlipidemia increases the risk of depression and that using statins is associated with a decreased risk of depression in patients with hyperlipidemia. (C) 2014 Elsevier Inc. All rightrs reserved.
C1 [Chuang, Chieh-Sen] Changhua Christian Hosp, Dept Neurol, Changhua, Taiwan.
   [Chuang, Chieh-Sen; Su, Hong-Lin] Natl Chung Hsing Univ, Taichung 40227, Taiwan.
   [Yang, Tse-Yen; Kao, Chia-Hung] China Med Univ Hosp, Dept Nucl Med, Taichung, Taiwan.
   [Yang, Tse-Yen; Kao, Chia-Hung] China Med Univ Hosp, PET Ctr, Taichung, Taiwan.
   [Yang, Tse-Yen; Sung, Fung-Chang; Kao, Chia-Hung] China Med Univ, Grad Inst Clin Med Sci, Coll Med, Sch Med, Taichung 404, Taiwan.
   [Muo, Chih-Hsin] China Med Univ Hosp, Management Off Hlth Data, Taichung, Taiwan.
   [Muo, Chih-Hsin] China Med Univ, Coll Med, Taichung 404, Taiwan.
C3 Changhua Christian Hospital; National Chung Hsing University; China
   Medical University Taiwan; China Medical University Hospital - Taiwan;
   China Medical University Taiwan; China Medical University Hospital -
   Taiwan; China Medical University Taiwan; China Medical University
   Taiwan; China Medical University Hospital - Taiwan; China Medical
   University Taiwan
RP Kao, CH (corresponding author), China Med Univ, Grad Inst Clin Med Sci, Coll Med, 2 Yuh Der Rd, Taichung 404, Taiwan.
EM d10040@mail.cmuh.org.tw
RI Chang, Chun-Hung/AAT-1641-2021; Huang, Chien-Chung/ABH-8727-2020; Yang,
   Tse-Yen/C-4259-2015
OI Yang, Tse-Yen/0000-0002-3165-132X
FU China Medical University Hospital [DMR-102-014, DMR-103-012]; Taiwan
   Ministry of Health and Welfare Clinical Trial and Research Center of
   Excellence [MOHW103-TDU-B-212-113002]; Health and welfare surcharge of
   tobacco products, China Medical University Hospital Cancer Research
   Center of Excellence (Taiwan) [MOHW103-TD-B-111-03]; International
   Research-Intensive Centers of Excellence in Taiwan (I-RiCE)
   [NSC101-2911-I-002-303]
FX Funding: This work was supported by the study projects (DMR-102-014,
   DMR-103-012) in China Medical University Hospital; Taiwan Ministry of
   Health and Welfare Clinical Trial and Research Center of Excellence
   (MOHW103-TDU-B-212-113002), Health and welfare surcharge of tobacco
   products, China Medical University Hospital Cancer Research Center of
   Excellence (MOHW103-TD-B-111-03, Taiwan); and International
   Research-Intensive Centers of Excellence in Taiwan (I-RiCE)
   (NSC101-2911-I-002-303). The funders had no role in study design, data
   collection and analysis, decision to publish or preparation of the
   manuscript. No additional external funding was received for this study.
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NR 46
TC 50
Z9 54
U1 1
U2 23
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0163-8343
EI 1873-7714
J9 GEN HOSP PSYCHIAT
JI Gen. Hosp. Psych.
PD SEP
PY 2014
VL 36
IS 5
BP 497
EP 501
DI 10.1016/j.genhosppsych.2014.05.008
PG 5
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA AN8RT
UT WOS:000340872400013
PM 24950917
DA 2025-06-11
ER

PT J
AU Georgakopoulos, C
   Vlachopoulos, C
   Tousoulis, D
AF Georgakopoulos, Christos
   Vlachopoulos, Charalambos
   Tousoulis, Dimitrios
TI Biomarkers of Atrial Fibrillation in Metabolic Syndrome
SO CURRENT MEDICINAL CHEMISTRY
LA English
DT Review
DE Biomarkers; Atrial fibrillation; Metabolic Syndrome; Troponin; BNP; GFR;
   Cystatin-C; Kidney disease; CRP; IL-6; Inflammation
ID C-REACTIVE PROTEIN; BRAIN NATRIURETIC PEPTIDE; CHRONIC KIDNEY-DISEASE;
   SERUM CYSTATIN-C; CARDIAC TROPONIN-T; RADIOFREQUENCY CATHETER ABLATION;
   ANGIOTENSIN-ALDOSTERONE SYSTEM; STRUCTURAL HEART-DISEASE; SINUS RHYTHM
   RESTORATION; CORONARY-ARTERY-DISEASE
AB Whether the increased atrial fibrillation (AF) risk in metabolic syndrome (MetS) patients is due to the syndrome as a whole or simply the sum of the risks of its individual component parts is still obscure. These two clinical entities share many pathophysiological links and thus distinction between a casual observation and a significant association is difficult. Biomarkers associated with pathogenesis of AF in the context of MetS have the ability to refine future risk prediction. In the present review we identify circulating substances that could be regarded as potential biomarkers for prediction of incident AF, or of cardiovascular events in the setting of AF in patients with MetS. Cardiac myocyte injury and stress markers (troponin and natriuretic peptides), markers of renal function (glomeral filtration rate, cystatin-C), and inflammation markers/mediators (interleukin-6, CRP) are promising biomarkers of patients with AF and MetS.
C1 [Georgakopoulos, Christos; Vlachopoulos, Charalambos; Tousoulis, Dimitrios] Univ Athens, Hypertens & Cardiometab Syndrome Unit, Dept Cardiol 1, Med Sch,Hippokrat Hosp, Athens, Greece.
C3 Hippokration General Hospital; National & Kapodistrian University of
   Athens
RP Vlachopoulos, C (corresponding author), Univ Athens, Hippokrat Hosp, Dept Cardiol 1, Athens Med Sch, Profiti Elia 24, Athens 14575, Greece.
EM cvlachop@otenet.gr
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NR 125
TC 8
Z9 8
U1 0
U2 5
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 0929-8673
EI 1875-533X
J9 CURR MED CHEM
JI Curr. Med. Chem.
PY 2019
VL 26
IS 5
BP 898
EP 908
DI 10.2174/0929867324666171012105528
PG 11
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Pharmacology &
   Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
GA HU6AM
UT WOS:000465361000011
PM 29022500
DA 2025-06-11
ER

PT J
AU Sumathipala, A
   Siribaddana, S
   Hotopf, M
   McGuffin, P
   Glozier, N
   Ball, H
   Kovas, Y
   Rijsdijk, F
   Yatawara, L
   Pariante, C
   Zavos, H
   Siriwardhana, C
   Pannala, G
   Jayaweera, K
   Adikari, A
   Gunewardane, D
AF Sumathipala, Athula
   Siribaddana, Sisira
   Hotopf, Mathew
   McGuffin, Peter
   Glozier, Nick
   Ball, Harriet
   Kovas, Yulia
   Rijsdijk, Fruhling
   Yatawara, Lalani
   Pariante, Carmine
   Zavos, Helena
   Siriwardhana, Chesmal
   Pannala, Gayani
   Jayaweera, Kaushalya
   Adikari, Anushka
   Gunewardane, Dinesha
TI The Sri Lankan Twin Registry: 2012 Update
SO TWIN RESEARCH AND HUMAN GENETICS
LA English
DT Article
DE twin research; Sri Lanka; developing world; North-South collaboration;
   gene-environment interaction
ID ENVIRONMENTAL CONTRIBUTIONS; DEPRESSION; COUNTRIES; OVERLAP; FATIGUE
AB The Sri Lankan Twin Registry (SLTR), established in 1997, is a unique resource for twin and genetic research in a low- and middle-income country (LMIC). It comprises of a volunteer cohort of 14,120 twins (7,060 pairs) and 119 sets of triplets, and a population-based cohort of 19,040 (9,520 pairs) twins and 89 sets of triplets. Several studies have been conducted using this registry, including the Colombo Twin and Singleton Study (CoTaSS 1; 4,387 twins, 2,311 singletons), which have explored the prevalence and heritability of a range of psychiatric disorders as well as gene-environmental interplay. Currently, a follow-up study (CoTaSS 2) of the same cohort is underway, looking at the prevalence and interrelationship of key cardiovascular and metabolic risk markers (e. g., metabolic syndrome). A significant feature of CoTaSS 2 is the establishment of a biobank. Current SLTR work is extending beyond mental health and the interface between mental and physical health to new horizons, extending collaborations with the wider global twin research community. Ethics and governance have been given special emphasis in the initiative. Capacity building and public engagement are two crucial components. Establishment of a state-of-the-art genetic laboratory was a major accomplishment. SLTR is a classic showcase of successful North-South partnership in building a progressive research infrastructure in a LMIC.
C1 [Sumathipala, Athula; Siribaddana, Sisira; Yatawara, Lalani; Siriwardhana, Chesmal; Pannala, Gayani; Jayaweera, Kaushalya; Adikari, Anushka; Gunewardane, Dinesha] Inst Res & Dev, Colombo, Sri Lanka.
   [Sumathipala, Athula; Hotopf, Mathew; McGuffin, Peter; Ball, Harriet; Rijsdijk, Fruhling; Pariante, Carmine; Zavos, Helena; Siriwardhana, Chesmal] Kings Coll London, Inst Psychiat, London WC2R 2LS, England.
   [Siribaddana, Sisira] Teaching Hosp, Dept Med, Professorial Unit, Anuradhapura, Sri Lanka.
   [Glozier, Nick] Univ Sydney, Sydney Med Sch, Sydney, NSW 2006, Australia.
   [Kovas, Yulia] Univ London, London, England.
   [Yatawara, Lalani] Univ Peradeniya, Fac Allied Hlth Sci, Kandy, Sri Lanka.
C3 University of London; King's College London; University of Sydney;
   University of London; University of Peradeniya
RP Sumathipala, A (corresponding author), Inst Res & Dev, 393-3 Lily Ave, Off Robert Gunawardane M 10120, Battaramulla, Sri Lanka.
EM athula.sumathipala@kcl.ac.uk
RI Rijsdijk, Fruhling/B-4191-2011; Glozier, Nick/A-7440-2011; Kovas,
   Yulia/L-7116-2019; Zavos, Helena/B-2153-2013; Ball,
   Harriet/AAR-4284-2021; Sumathipala, Athula/W-2805-2019; Hotopf,
   Matthew/E-4971-2010; McGuffin, Peter/A-1565-2012; Jayaweera,
   Kaushalya/AAE-7333-2019; Siriwardhana, Chesmal/E-8150-2012; Siribaddana,
   Sisira/I-2295-2016; Pariante, Carmine Maria/B-1297-2011
OI Zavos, Helena/0000-0001-8165-6877; Glozier, Nick/0000-0002-0476-9146;
   Kovas, Yulia/0000-0001-9633-6374; Rijsdijk,
   Fruhling/0000-0003-4762-2803; Jayaweera, Kaushalya/0000-0003-3780-0901;
   Siriwardhana, Chesmal/0000-0003-3614-9088; Hotopf,
   Matthew/0000-0002-3980-4466; Ball, Harriet/0000-0002-2137-7582;
   Siribaddana, Sisira/0000-0001-5821-2557; Pariante, Carmine
   Maria/0000-0002-9132-5091
FU Wellcome Trust, United Kingdom [060379/Z/00/Z, 069629/Z/02/Z,
   093206/Z/10/Z]; Australian NHMRC [571421, 566529]; Wellcome Trust
   [093206/Z/10/Z] Funding Source: Wellcome Trust; MRC [G108/603] Funding
   Source: UKRI
FX We received three funding grants (060379/Z/00/Z, 069629/Z/02/Z,
   093206/Z/10/Z) from the Wellcome Trust, United Kingdom, to support this
   work. SS, HB, and YK were employed full time for CoTaSS 1 and KJ and HZ
   (full-time) and SS, AA, GP, and DG (part-time) for CoTaSS 2. The sleep
   and activity substudy is funded by the Australian NHMRC (grant numbers
   571421 and 566529). We would like to acknowledge all those who were
   actively involved since the inception of SLTR, including those who have
   been acknowledged in the previous publications. We would also like to
   acknowledge Chamali Jayasinghe, Maneesha Jayaweera, Nilanthi
   Priyadharshani, Mekala Narangoda, Janani Marasingha, Aruna Walisundara,
   Nadun Perera, Hansini Gamage, Vidath samarakkody, Udeni Samanmalie, T.
   Jeyakumar, and Dr. Patricia Zunszain for their contribution to CoTaSS 1
   and 2. We would further like to acknowledge the IRD executive committee,
   other staff, and research assistants.
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NR 21
TC 9
Z9 9
U1 0
U2 12
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
SN 1832-4274
EI 1839-2628
J9 TWIN RES HUM GENET
JI Twin Res. Hum. Genet.
PD FEB
PY 2013
VL 16
IS 1
BP 307
EP 312
DI 10.1017/thg.2012.119
PG 6
WC Genetics & Heredity; Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Genetics & Heredity; Obstetrics & Gynecology
GA 087YD
UT WOS:000314799700046
PM 23302519
OA Bronze
DA 2025-06-11
ER

PT S
AU Suzuki, A
   Diehl, AM
AF Suzuki, Ayako
   Diehl, Anna Mae
BE Caskey, CT
TI Nonalcoholic Steatohepatitis
SO ANNUAL REVIEW OF MEDICINE, VOL 68
SE Annual Review of Medicine
LA English
DT Review; Book Chapter
DE nonalcoholic fatty liver disease; lipotoxicity; adaptive mechanisms;
   hepatocyte damage; hepatic fibrosis
ID FATTY-LIVER-DISEASE; HEDGEHOG PATHWAY ACTIVATION; DIET-INDUCED OBESITY;
   KILLER T-CELLS; METABOLIC SYNDROME; GENERAL-POPULATION;
   INSULIN-RESISTANCE; HEPATIC STEATOSIS; BARIATRIC SURGERY; OXIDATIVE
   STRESS
AB Nonalcoholic steatohepatitis (NASH) has become a major cause of cirrhosis and liver-related deaths worldwide. NASH is strongly associated with obesity and the metabolic syndrome, conditions that cause lipid accumulation in hepatocytes (hepatic steatosis). It is not well understood why some, but not other, individuals with hepatic steatosis develop NASH. The factors that determine whether or not NASH progresses to cirrhosis are also unclear. This review summarizes key components of NASH pathogenesis and discusses how inherent and acquired variations in regulation of these processes impact the risk for NASH and NASH cirrhosis.
C1 [Suzuki, Ayako] Univ Arkansas Med Sci, Dept Med, Little Rock, AR 72205 USA.
   [Diehl, Anna Mae] Duke Univ, Sch Med, Div Gastroenterol, Durham, NC 27710 USA.
C3 University of Arkansas System; University of Arkansas Medical Sciences;
   Duke University
RP Diehl, AM (corresponding author), Duke Univ, Sch Med, Div Gastroenterol, Durham, NC 27710 USA.
EM annamae.diehl@duke.edu
RI Suzuki, Ayako/A-7656-2009
OI Suzuki, Ayako/0000-0003-1824-1067
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NR 98
TC 122
Z9 132
U1 0
U2 27
PU ANNUAL REVIEWS
PI PALO ALTO
PA 4139 EL CAMINO WAY, PO BOX 10139, PALO ALTO, CA 94303-0897 USA
SN 0066-4219
BN 978-0-8243-0568-0
J9 ANNU REV MED
JI Annu. Rev. Med.
PY 2017
VL 68
BP 85
EP 98
DI 10.1146/annurev-med-051215-031109
PG 14
WC Medicine, Research & Experimental
WE Book Citation Index – Science (BKCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA BH1NW
UT WOS:000398282900007
PM 27732787
DA 2025-06-11
ER

PT J
AU Yang, C
   Xu, ZX
   Deng, QC
   Huang, QD
   Wang, X
   Huang, FH
AF Yang, Chen
   Xu, Zhenxia
   Deng, Qianchun
   Huang, Qingde
   Wang, Xu
   Huang, Fenghong
TI Beneficial effects of flaxseed polysaccharides on metabolic syndrome via
   gut microbiota in high-fat diet fed mice
SO FOOD RESEARCH INTERNATIONAL
LA English
DT Article
DE Flaxseed polysaccharides; Metabolic syndrome; Gut microbiota;
   Akkermansia
ID INDUCED OBESITY; AKKERMANSIA-MUCINIPHILA; OXIDATIVE STRESS;
   LIPID-METABOLISM; BODY-WEIGHT; FIBER; ACIDS; RNA; INFLAMMATION;
   MODULATION
AB Flaxseed (Linum usitatissimum L.) is known as healthy food for its anti-obesity and lipid modulating properties. However, the effects of flaxseed polysaccharide (FSP) on metabolic syndrome (MetS) and gut microbiota are still poorly understood. Here, we investigated the effects of FSP on lipid metabolism and gut microbiota in high-fat-diet-fed mice. FSP effectively reduced the serum fasting glucose, total triglyceride and total cholesterol levels. FSP consumption adipose accumulation impacted the gut microbiome at different taxonomic levels by increasing the proportions of beneficial Akkermansia and Bifidobacterium and decreasing the disease or obesity associated Oscillospira and Odoribacteraceae. These changes were highly correlated with the regulation of expression levels of lipid metabolism involved genes in the liver. The restoration of total SCFAs, especially propionate and butyrate might be an important strategy for mitigating HFD induced metabolic disorders. These findings suggest that FSP may use as a prebiotic for preventing MetS by modulating the gut microbiota.
C1 [Yang, Chen; Xu, Zhenxia; Deng, Qianchun; Huang, Qingde; Huang, Fenghong] Chinese Acad Agr Sci, Oil Crops & Lipids Proc Technol Natl & Local Join, Hubei Key Lab Lipid Chem & Nutr, Key Lab Oilseeds Proc,Oil Crops Res Inst,Minist A, 2 Xudong 2nd Rd, Wuhan 430062, Peoples R China.
   [Huang, Fenghong] Shandong Acad Agr Sci, Inst Agrofood Sci & Technol, 202 Gongye North Rd, Jinan 250100, Peoples R China.
   [Wang, Xu] Huazhong Agr Univ, 1 Shizishan St, Wuhan 430070, Peoples R China.
C3 Chinese Academy of Agricultural Sciences; Oil Crops Research Institute,
   CAAS; Shandong Academy of Agricultural Sciences; Huazhong Agricultural
   University
RP Yang, C (corresponding author), Chinese Acad Agr Sci, Oil Crops & Lipids Proc Technol Natl & Local Join, Hubei Key Lab Lipid Chem & Nutr, Key Lab Oilseeds Proc,Oil Crops Res Inst,Minist A, 2 Xudong 2nd Rd, Wuhan 430062, Peoples R China.; Huang, FH (corresponding author), Chinese Acad Agr Sci, Oil Crops Res Inst, 2 Xudong 2nd Rd, Wuhan 430062, Peoples R China.
EM yangchen@caas.cn
RI Yang, Chen/AAM-8727-2020
FU Central Public-interest Scientific Institution Basal Research Fund for
   Chinese Academy of Agricultural Sciences [1610172019009]; Earmarked Fund
   for China Agriculture Research System [CARS-14]; Agricultural Science
   and Technology Innovation Project of Chinese Academy of Agricultural
   Sciences [CAASASTIP-2013-OCRI]; Taishan Scholar Project
FX This work was supported by the Central Public-interest Scientific
   Institution Basal Research Fund for Chinese Academy of Agricultural
   Sciences (1610172019009), the Earmarked Fund for China Agriculture
   Research System (CARS-14), the Agricultural Science and Technology
   Innovation Project of Chinese Academy of Agricultural Sciences
   (CAASASTIP-2013-OCRI), Taishan Scholar Project (Feng-Hong Huang).
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NR 63
TC 76
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U1 5
U2 101
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0963-9969
EI 1873-7145
J9 FOOD RES INT
JI Food Res. Int.
PD MAY
PY 2020
VL 131
AR 108994
DI 10.1016/j.foodres.2020.108994
PG 11
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA LG7BX
UT WOS:000528252800008
PM 32247451
DA 2025-06-11
ER

PT J
AU Cardinali, DP
   Vigo, DE
AF Cardinali, Daniel P.
   Vigo, Daniel E.
TI Melatonin, mitochondria, and the metabolic syndrome
SO CELLULAR AND MOLECULAR LIFE SCIENCES
LA English
DT Review
DE Melatonin; Metabolic syndrome; Mitochondria; Inflammation; Diabetes;
   Obesity; Insulin signaling; Aging
ID HIGH-FAT-DIET; HUMAN-PLATELET-AGGREGATION; POLYCYSTIC-OVARY-SYNDROME;
   NOCTURNAL BLOOD-PRESSURE; TYPE-2 DIABETIC-PATIENTS; REDUCES BODY-WEIGHT;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; NONALCOHOLIC STEATOHEPATITIS;
   THROMBOXANE-B2 PRODUCTION
AB A number of risk factors for cardiovascular disease including hyperinsulinemia, glucose intolerance, dyslipidemia, obesity, and elevated blood pressure are collectively known as metabolic syndrome (MS). Since mitochondrial activity is modulated by the availability of energy in cells, the disruption of key regulators of metabolism in MS not only affects the activity of mitochondria but also their dynamics and turnover. Therefore, a link of MS with mitochondrial dysfunction has been suspected since long. As a chronobiotic/cytoprotective agent, melatonin has a special place in prevention and treatment of MS. Melatonin levels are reduced in diseases associated with insulin resistance like MS. Melatonin improves sleep efficiency and has antioxidant and anti-inflammatory properties, partly for its role as a metabolic regulator and mitochondrial protector. We discuss in the present review the several cytoprotective melatonin actions that attenuate inflammatory responses in MS. The clinical data that support the potential therapeutical value of melatonin in human MS are reviewed.
C1 [Cardinali, Daniel P.; Vigo, Daniel E.] UCA, CONICET, BIOMED, Av Alicia Moreau de Justo 1500,4o Piso, RA-1107 Buenos Aires, DF, Argentina.
   [Cardinali, Daniel P.; Vigo, Daniel E.] Pontificia Univ Catolica Argentina, Fac Med Sci, Dept Teaching & Res, Av Alicia Moreau de Justo 1500,4o Piso, RA-1107 Buenos Aires, DF, Argentina.
C3 Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET);
   Pontificia Universidad Catolica Argentina; Pontificia Universidad
   Catolica Argentina
RP Cardinali, DP (corresponding author), UCA, CONICET, BIOMED, Av Alicia Moreau de Justo 1500,4o Piso, RA-1107 Buenos Aires, DF, Argentina.; Cardinali, DP (corresponding author), Pontificia Univ Catolica Argentina, Fac Med Sci, Dept Teaching & Res, Av Alicia Moreau de Justo 1500,4o Piso, RA-1107 Buenos Aires, DF, Argentina.
EM danielcardinali@uca.edu.ar
OI Vigo, Daniel Eduardo/0000-0003-2291-245X
FU Agencia Nacional de Promocion Cientifica y Tecnologica, Argentina [PICT
   2007 01045, 2012 0984]
FX Studies in authors' laboratory were supported by Grants PICT 2007 01045
   and 2012 0984 from the Agencia Nacional de Promocion Cientifica y
   Tecnologica, Argentina.
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NR 180
TC 42
Z9 48
U1 1
U2 53
PU SPRINGER BASEL AG
PI BASEL
PA PICASSOPLATZ 4, BASEL, 4052, SWITZERLAND
SN 1420-682X
EI 1420-9071
J9 CELL MOL LIFE SCI
JI Cell. Mol. Life Sci.
PD NOV
PY 2017
VL 74
IS 21
BP 3941
EP 3954
DI 10.1007/s00018-017-2611-0
PG 14
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA FJ5AB
UT WOS:000412754800006
PM 28819865
OA Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Lee, HE
   Kim, HR
   Kong, JO
   Jang, TW
   Myong, JP
   Koo, JW
   Kim, I
AF Lee, Hye-Eun
   Kim, Hyoung-Ryoul
   Kong, Jung-Ok
   Jang, Tae-Won
   Myong, Jun-Pyo
   Koo, Jung-Wan
   Kim, Inah
TI Weekend work and depressive symptoms among Korean employees
SO CHRONOBIOLOGY INTERNATIONAL
LA English
DT Article
DE Depression; weekend work; work schedule
ID METABOLIC SYNDROME; MENTAL-HEALTH; SHIFT WORK; DISORDERS; FAMILY;
   VALIDITY; RISK; ASSOCIATIONS; SCHEDULES; MOOD
AB The purpose of this study was to quantify the association between weekend work and depressive symptoms in a representative sample of Korean employees. Subjects were 29 171 employees of companies in Korea. Data were obtained as part of the 2011 Korean Working Conditions Survey. Depressive symptoms were measured as a score of <= 7 on the World Health Organization Well-being Index. The association between weekend work and depressive symptoms was quantified using logistic regression, controlling for sociodemographic and work-related factors including the number of hours worked per week and stratified by gender. The prevalence of depressive symptoms was higher in employees who reported working at least one weekend day in the past month than in employees who reported working no weekend days in the past month. After controlling for confounders, including the number of hours worked per week, 1-4 days of weekend work in the past month (odds ratio [95% confidence interval] of 1.36 [1.18-1.57] in males and 1.32 [1.12-1.58] in females) and 44 days of weekend work in the past month (odds ratio [95% confidence interval] of 1.45 [1.19-1.78] in males and 1.36 [1.07-1.73] in females) were significantly associated with depressive symptoms. Weekend work was related with a significant increase in the prevalence of depressive symptoms in Korean workers.
C1 [Lee, Hye-Eun; Kim, Hyoung-Ryoul; Kong, Jung-Ok; Jang, Tae-Won; Myong, Jun-Pyo; Koo, Jung-Wan] Catholic Univ Korea, Dept Occupat & Environm Med, Coll Med, Seoul 137701, South Korea.
   [Kong, Jung-Ok] Kangwon Natl Univ, Grad Sch Med, Dept Prevent Med, Chunchon, South Korea.
   [Kim, Inah] Yonsei Univ, Dept Occupat & Environm Hlth, Grad Sch Publ Hlth, Seoul 120749, South Korea.
C3 Catholic University of Korea; Kangwon National University; Yonsei
   University; Yonsei University Health System
RP Jang, TW (corresponding author), Catholic Univ Korea, Dept Occupat & Environm Med, Coll Med, 222 Banpo Daero, Seoul 137701, South Korea.
EM om1024@hanmail.net
RI Lee, Hye Eun/AAE-6317-2022; Myong, Jun-Pyo/M-7351-2019; Kim,
   Hyungduk/CAH-5630-2022
OI Lee, Hye-Eun/0000-0003-4648-5042; Myong, Jun-pyo/0000-0001-8674-1034;
   Jang, Tae-Won/0000-0003-2624-3257
FU Korean Occupational Safety and Health Agency (KOSHA); KOSHA
FX This study was supported by the Korean Occupational Safety and Health
   Agency (KOSHA). The authors gratefully acknowledge support from KOSHA.
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U1 2
U2 14
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 0742-0528
EI 1525-6073
J9 CHRONOBIOL INT
JI Chronobiol. Int.
PD MAR
PY 2015
VL 32
IS 2
BP 262
EP 269
DI 10.3109/07420528.2014.965826
PG 8
WC Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Life Sciences & Biomedicine - Other Topics; Physiology
GA CD3TP
UT WOS:000351005100013
PM 25290039
DA 2025-06-11
ER

PT J
AU Morgan, VA
   Waterreus, A
   Jablensky, A
   Mackinnon, A
   McGrath, JJ
   Carr, V
   Bush, R
   Castle, D
   Cohen, M
   Harvey, C
   Galletly, C
   Stain, HJ
   Neil, AL
   McGorry, P
   Hocking, B
   Shah, S
   Saw, S
AF Morgan, Vera A.
   Waterreus, Anna
   Jablensky, Assen
   Mackinnon, Andrew
   McGrath, John J.
   Carr, Vaughan
   Bush, Robert
   Castle, David
   Cohen, Martin
   Harvey, Carol
   Galletly, Cherrie
   Stain, Helen J.
   Neil, Amanda L.
   McGorry, Patrick
   Hocking, Barbara
   Shah, Sonal
   Saw, Suzy
TI People living with psychotic illness in 2010: The second Australian
   national survey of psychosis
SO AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
LA English
DT Article
DE Medication; prevalence; physical health; psychosis; substance use
ID METABOLIC SYNDROME; RELIABILITY; INSTRUMENT; QUESTIONNAIRE; PREVALENCE;
   DISEASE; SCALE
AB Objective: The 2010 Survey of High Impact Psychosis (SHIP) is Australia's second national psychosis survey. This paper provides an overview of its findings, including comparisons with the first psychosis survey and general population data.
   Methods: The survey covered 1.5 million people aged 18-64 years, approximately 10% of Australians in this age group. A two-phase design was used. In phase 1, screening for psychosis took place in public mental health services and non-government organizations supporting people with mental illness. In phase 2, 1825 of those screen-positive for psychosis were randomly selected and interviewed. Data collected included symptomatology, substance use, functioning, service utilization, medication use, education, employment, housing, and physical health including fasting blood samples.
   Results: The estimated 1-month treated prevalence of psychotic disorders in public treatment services was 3.1 people per 1000 population; the 12-month treated prevalence was 4.5 people per 1000. The majority (63.0%) of participants met ICD-10 criteria for schizophrenia/schizoaffective disorder. One-half (49.5%) reported attempting suicide in their lifetime and two-thirds (63.2%) were rated as impaired in their ability to socialize. Over half (54.8%) had metabolic syndrome. The proportion currently smoking was 66.1%. Educational achievement was low. Only 21.5% were currently employed. Key changes in the 12 years since the first survey included: a marked drop in psychiatric inpatient admissions; a large increase in the proportion attending community mental health clinics; increased use of rehabilitation services and non-government organizations supporting people with mental illness; a major shift from typical to atypical antipsychotics; and large increases in the proportions with lifetime alcohol or drug abuse/dependence.
   Conclusion: People with psychotic illness face multiple challenges. An integrated approach to service provision is needed to ensure that their living requirements and needs for social participation are met, in addition to their very considerable mental and physical health needs.
C1 [Morgan, Vera A.] Univ Western Australia, Neuropsychiat Epidemiol Res Unit M571, Sch Psychiat & Clin Neurosci, Crawley, WA 6009, Australia.
   [Mackinnon, Andrew; McGorry, Patrick] Orygen Youth Hlth Res Ctr, Melbourne, Vic, Australia.
   [Mackinnon, Andrew; McGorry, Patrick] Univ Melbourne, Ctr Youth Mental Hlth, Melbourne, Vic, Australia.
   [McGrath, John J.] Univ Queensland, Queensland Brain Inst, Brisbane, Qld, Australia.
   [McGrath, John J.] Queensland Ctr Mental Hlth Res, Brisbane, Qld, Australia.
   [Carr, Vaughan] Univ New S Wales, Sch Psychiat, Sydney, NSW, Australia.
   [Carr, Vaughan] Schizophrenia Res Inst, Sydney, NSW, Australia.
   [Bush, Robert] Univ Queensland, Hlth Commun Res Ctr, Ipswich, Qld, Australia.
   [Castle, David; Harvey, Carol; McGorry, Patrick] Univ Melbourne, Dept Psychiat, Melbourne, Vic, Australia.
   [Castle, David] St Vincents Hosp, Melbourne, Vic, Australia.
   [Cohen, Martin] Hunter New England Mental Hlth, Newcastle, NSW, Australia.
   [Cohen, Martin] Univ Newcastle, Sch Med & Publ Hlth, Newcastle, NSW 2300, Australia.
   [Harvey, Carol] NW Area Mental Hlth Serv, Psychosocial Res Ctr, Coburg, Australia.
   [Galletly, Cherrie] Univ Adelaide, Sch Med, Adelaide, SA, Australia.
   [Galletly, Cherrie] Ramsay Hlth Care SA Mental Hlth Serv, Adelaide, SA, Australia.
   [Galletly, Cherrie] Adelaide Metro Mental Hlth Directorate, No Sector, Adelaide, SA, Australia.
   [Stain, Helen J.] Univ Newcastle, Ctr Rural & Remote Mental Hlth, Newcastle, NSW 2300, Australia.
   [Hocking, Barbara] SANE Australia, Melbourne, Vic, Australia.
   [Saw, Suzy] Australian Govt Dept Hlth & Ageing, Canberra, ACT, Australia.
C3 University of Western Australia; Orygen, The National Centre of
   Excellence in Youth Mental Health; Orygen, The National Centre of
   Excellence in Youth Mental Health; University of Melbourne; University
   of Queensland; Queensland Centre for Mental Health Research; University
   of New South Wales Sydney; Schizophrenia Research Institute; University
   of Queensland; University of Melbourne; St Vincent's Health; St
   Vincent's Hospital Melbourne; NSW Health; St Vincents Hospital Sydney;
   University of Newcastle; University of Adelaide; Ramsay Health Care
   Limited; University of Newcastle
RP Morgan, VA (corresponding author), Univ Western Australia, Neuropsychiat Epidemiol Res Unit M571, Sch Psychiat & Clin Neurosci, 35 Stirling Highway, Crawley, WA 6009, Australia.
EM vera.morgan@uwa.edu.au
RI Harvey, Carol/KHB-1944-2024; McGorry, Patrick/O-4115-2019; Morgan,
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OI McGrath, John/0000-0002-4792-6068; Mackinnon,
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   Anna/0000-0002-1648-7701; Castle, David/0000-0002-3075-1580; McGorry,
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PD AUG
PY 2012
VL 46
IS 8
SI SI
BP 735
EP 752
DI 10.1177/0004867412449877
PG 18
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 986IH
UT WOS:000307334800010
PM 22696547
DA 2025-06-11
ER

PT J
AU Nie, PH
   Hu, LH
   Feng, XY
   Xu, HY
AF Nie, Penghui
   Hu, Liehai
   Feng, Xiaoyan
   Xu, Hengyi
TI Gut Microbiota Disorders and Metabolic Syndrome: Tales of a Crosstalk
   Process
SO NUTRITION REVIEWS
LA English
DT Review
DE metabolic syndrome; gut microbiota; host-microbial metabolic axis;
   short-chain fatty acids; potential therapeutic strategies
ID NONALCOHOLIC FATTY LIVER; TYPE-2 DIABETES-MELLITUS; INSULIN-RESISTANCE;
   INTESTINAL MICROBIOTA; MOLECULAR-MECHANISMS; OXIDATIVE STRESS;
   IMMUNE-SYSTEM; BODY-WEIGHT; ACIDS; INFLAMMATION
AB The microbiota in humans consists of trillions of microorganisms that are involved in the regulation of the gastrointestinal tract and immune and metabolic homeostasis. The gut microbiota (GM) has a prominent impact on the pathogenesis of metabolic syndrome (MetS). This process is reciprocal, constituting a crosstalk process between the GM and MetS. In this review, GM directly or indirectly inducing MetS via the host-microbial metabolic axis has been systematically reviewed. Additionally, the specifically altered GM in MetS are detailed in this review. Moreover, short-chain fatty acids (SCFAs), as unique gut microbial metabolites, have a remarkable effect on MetS, and the role of SCFAs in MetS-related diseases is highlighted to supplement the gaps in this area. Finally, the existing therapeutics are outlined, and the superiority and shortcomings of different therapeutic approaches are discussed, in hopes that this review can contribute to the development of potential treatment strategies.
C1 [Nie, Penghui; Hu, Liehai; Feng, Xiaoyan; Xu, Hengyi] Nanchang Univ, State Key Lab Food Sci & Technol, 235 Nanjing East Rd, Nanchang 330047, Peoples R China.
   [Xu, Hengyi] Nanchang Univ, Int Inst Food Innovat Co Ltd, Nanchang 330200, Peoples R China.
C3 Nanchang University; Nanchang University
RP Xu, HY (corresponding author), Nanchang Univ, State Key Lab Food Sci & Resources, 235 Nanjing East Rd, Nanchang 330047, Peoples R China.
EM HengyiXu@ncu.edu.cn
RI Hu, Liehai/GQA-7806-2022
OI Hu, Liehai/0000-0001-6806-8763
FU National Natural Science Foundation of China [82060606]
FX This work was supported by National Natural Science Foundation of China
   (82060606).
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NR 153
TC 0
Z9 0
U1 6
U2 8
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0029-6643
EI 1753-4887
J9 NUTR REV
JI Nutr. Rev.
PD MAY
PY 2025
VL 83
IS 5
BP 908
EP 924
DI 10.1093/nutrit/nuae157
EA NOV 2024
PG 17
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 1SP5F
UT WOS:001350126900001
PM 39504479
DA 2025-06-11
ER

PT J
AU Mansoury, MMS
AF Mansoury, Manal M. S.
TI A review of the antidiabetic, antihyperlipidemic, and related metabolic
   disorder documented activities of Emblic fruits (Phyllanthus emblica L.)
SO JOURNAL OF COMPLEMENTARY MEDICINE RESEARCH
LA English
DT Review
DE Diabetes; metabolic syndrome; Emblic fruit
ID OFFICINALIS GAERTN.; DIABETES-MELLITUS; OXIDATIVE STRESS; EXTRACT; AMLA;
   IDENTIFICATION; EFFICACY; PROFILE; MODEL; ACID
AB Diabetes is a risky metabolic chronic sickness that threatens the lives and health of individuals, families, and communities everywhere. Management of diabetes and related metabolic syndrome (MS) relies heavily on diet. There are reports of folk plants showing varying levels of antihyperglycemic activity. Phyllanthus emblica Linn (syn. Emblica officinalis) (often referred to Emblic, Indian gooseberry, or amla) is a perennial tree in the Euphorbiaceae family. Due to the high concentration of phenolic compounds, Emblic fruit may be considered a plant source of natural antioxidants. Numerous studies have demonstrated Emblic fruit's benefits on humans and animals that are antihyperglycemic, anti-in-flammatory, antihyperlipidemic, antibacterial, analgesic and antipyretic, adaptogenic, hepatoprotective, anticancer, antiulcerogenic, and antioxidant. This review provided an overview of the published scientific studies (experimental and clinical) that documented the potential antidiabetic and antihyperlipidemic benefits associated with consuming Emblic fruits. In addition, the possible activity regarding related metabolic syndrome and diabetes complications was assessed.
C1 [Mansoury, Manal M. S.] King Abdulaziz Univ, Fac Human Sci & Design, Dept Food & Nutr, Jeddah, Saudi Arabia.
C3 King Abdulaziz University
RP Mansoury, MMS (corresponding author), King Abdulaziz Univ, Fac Human Sci & Design, Dept Food & Nutr, Jeddah, Saudi Arabia.
EM mmmansouri@kau.edu.sa
RI Mansoury, Manal/ABC-0603-2022
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NR 60
TC 0
Z9 0
U1 0
U2 6
PU EJMANAGER LLC
PI WILMINGTON
PA 913 N MARKET ST, STE 200, WILMINGTON, DE 19801 USA
SN 2146-8397
EI 2577-5669
J9 J COMPL MED RES
JI J. Compl. Med. Res.
PY 2022
VL 13
IS 5
BP 1
EP 8
DI 10.5455/jcmr.2022.13.05.01
PG 8
WC Pharmacology & Pharmacy
WE Emerging Sources Citation Index (ESCI)
SC Pharmacology & Pharmacy
GA 9H4LM
UT WOS:000938804600001
DA 2025-06-11
ER

PT J
AU Jabir, NR
   Firoz, CK
   Khan, MS
   Zaidi, SK
   Ashraf, GM
   Shakil, S
   Kamal, MA
   Tabrez, S
AF Jabir, Nasimudeen R.
   Firoz, Chelapram Kandy
   Khan, Mohd. Shahnawaz
   Zaidi, Syed Kashif
   Ashraf, Ghulam Md.
   Shakil, Shazi
   Kamal, Mohammad Amjad
   Tabrez, Shams
TI Potential Linkage Between Cerebrovascular Diseases and Metabolic
   Syndrome
SO CURRENT DRUG METABOLISM
LA English
DT Review
DE Cerebrovascular disease; dislipidemia; endothelial dysfunction;
   hypertension; insulin resistance; metabolic syndrome; obesity
ID C-REACTIVE PROTEIN; FREE FATTY-ACID; INSULIN-RESISTANCE;
   ISCHEMIC-STROKE; OXIDATIVE STRESS; RISK-FACTOR; INTERLEUKIN-6 LEVELS;
   CHOLESTEROL-LEVELS; VASCULAR RISK; GLYCATION
AB Cerebrovascular disease (CD) and metabolic syndrome (MetS) are two devastating health dilemma that continues to be a potential contributor to disability and mortality in human population all across the world. Scientific data clearly shows several mechanistic similarities between these two co-existing and interlinked conditions. The linkage exacerbates ongoing patho-physiological condition towards more lethal events. In view of the presence of modifiable risk factors in both CD and MetS, their management holds potential therapeutic value. Hence, developing common treatment strategies for these diseases could involve common molecular agents. In this communication, we have summarized some of the common pathological conditions viz. abdominal obesity, insulin resistance, dyslipidemia, hypertension, and endothelial dysfunction that further deteriorate existing homeostasis in CD and MetS. Based on our article, it is advocated that substantial improvements in novel multi-targeted drug discovery could provide the effective treatment methods in order to avoid the fatal complications related with CD and MetS.
C1 [Jabir, Nasimudeen R.; Firoz, Chelapram Kandy; Ashraf, Ghulam Md.; Kamal, Mohammad Amjad; Tabrez, Shams] King Abdulaziz Univ, King Fahd Med Res Ctr, POB 80216, Jeddah 21589, Saudi Arabia.
   [Khan, Mohd. Shahnawaz] King Saud Univ, Dept Biochem, Coll Sci, Prot Res Chair, Riyadh, Saudi Arabia.
   [Zaidi, Syed Kashif] King Abdulaziz Univ, Ctr Excellence Genom Med Res, Jeddah, Saudi Arabia.
   [Shakil, Shazi] King Abdulaziz Univ, KACST Technol Innovat Ctr Personalized Med, Jeddah, Saudi Arabia.
   [Shakil, Shazi] King Abdulaziz Univ, Fac Appl Med Sci, Dept Med Lab Technol, Jeddah, Saudi Arabia.
   [Kamal, Mohammad Amjad] Enzymoics, Hebersham, NSW, Australia.
   [Kamal, Mohammad Amjad] Novel Global Community Educ Fdn, 7 Peterlee Pl, Hebersham, NSW, Australia.
C3 King Abdulaziz University; King Saud University; King Abdulaziz
   University; King Abdulaziz University; King Abdulaziz University
RP Tabrez, S (corresponding author), King Abdulaziz Univ, King Fahd Med Res Ctr, POB 80216, Jeddah 21589, Saudi Arabia.
EM shamstabrez1@gmail.com
RI Kamal, Mohammad/J-2918-2014; Zaidi, Syed/A-6160-2013; Zyoud,
   Samer/ABI-6476-2020; Rehumathbeevi, Jabir/H-9483-2012; Tabrez,
   Shams/H-9476-2012; Ashraf, Ghulam Md/H-9485-2012; Shakil,
   Shazi/K-4132-2015; CHELAPRAM KANDY, FIROZ/H-9487-2012
OI Tabrez, Shams/0000-0003-4550-415X; Ashraf, Ghulam
   Md/0000-0002-9820-2078; Shakil, Shazi/0000-0003-4075-9153; CHELAPRAM
   KANDY, FIROZ/0000-0002-8832-9411
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NR 99
TC 13
Z9 13
U1 0
U2 9
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1389-2002
EI 1875-5453
J9 CURR DRUG METAB
JI Curr. Drug Metab.
PY 2017
VL 18
IS 1
BP 62
EP 68
DI 10.2174/1389200217666160810155055
PG 7
WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
GA EP2ZW
UT WOS:000397253300009
PM 27515564
DA 2025-06-11
ER

PT J
AU Shen, F
   Zhuang, JC
   Wang, QQ
   Zhang, JH
   Huang, Y
   Mo, QF
   Zhao, MJ
   Wang, J
   Zhong, H
   Feng, FQ
AF Shen, Fei
   Zhuang, Jiachen
   Wang, Qianqian
   Zhang, Junhui
   Huang, Ying
   Mo, Qiufen
   Zhao, Mingjie
   Wang, Jing
   Zhong, Hao
   Feng, Fengqin
TI Enhancement in the metabolic profile of sea buckthorn juice via
   fermentation for its better efficacy on attenuating diet-induced
   metabolic syndrome by targeting gut microbiota
SO FOOD RESEARCH INTERNATIONAL
LA English
DT Article
DE Metabolomic alterations; Sea buckthorn juice; Fermentation; Gut
   microbiota; Metabolic syndrome
ID HIPPOPHAE-RHAMNOIDES L.; INSULIN-RESISTANCE; INDUCED OBESITY;
   ASSOCIATION; MICE; ANTIOXIDANT; CONSUMPTION; FLAVONOIDS; EXTRACT; RISK
AB To enhance physiological activity and probiotic availability of sea buckthorn juice, sea buckthorn juice pulp (BHJ) went through fermentation to the fermented (FHJ). In vitro, FHJ displayed better antioxidant and antidiabetic capacities. To further study effects of FHJ on diet-induced metabolic syndrome (MS) and possible mechanisms in vivo, C57BL/6 mice were fed on BHJ and FHJ under high fat diet (HFD). FHJ, rather BHJ, displayed better performance on ameliorating hyperlipidemia, insulin resistance, and oxidative stress in MS. Mechanistically, FHJ intervention significantly reversed the microorganism dysbiosis by restoring the microbial diversity, and modulating obesogenic bacteria abundance, like Oscillospira. Furthermore, fermentation altered FHJ's metabolomics, especially flavonoids, contributing to interactions between FHJ and probiotics, like Akkermansia and Lachnospiraceae. Furthermore, short-chain fatty acids, related to ameliorations of MS, were increased by FHJ. This study demonstrated that interactions between metabolomic alterations in FHJ and microorganisms were vital to attenuate MS.
C1 [Shen, Fei; Zhuang, Jiachen; Wang, Qianqian; Zhang, Junhui; Huang, Ying; Mo, Qiufen; Zhao, Mingjie; Wang, Jing; Zhong, Hao; Feng, Fengqin] Zhejiang Univ, Coll Biosyst Engn & Food Sci, Hangzhou 310058, Peoples R China.
   [Wang, Jing; Feng, Fengqin] Zhejiang Univ, Ningbo Inst, Ningbo 315100, Peoples R China.
   [Zhong, Hao] Zhejiang Univ Technol, Coll Food Sci & Technol, Hangzhou 310014, Peoples R China.
C3 Zhejiang University; Zhejiang University; Zhejiang University of
   Technology
RP Wang, J; Zhong, H; Feng, FQ (corresponding author), Zhejiang Univ, Coll Biosyst Engn & Food Sci, Hangzhou 310058, Peoples R China.
EM wangjzju@zju.edu.cn; zhonghao@zjut.edu.cn
RI Wang, Jing/ABB-5658-2021
FU Zhejiang Provincial Natural Science Foundation of China, China; National
   Natural Science Foundation of China, China; Fundamental Research Funds
   for the Central Universities, China;  [LR18C200002];  [U1703105]; 
   [2017QNA6006]
FX This study was supported by Zhejiang Provincial Natural Science
   Foundation of China, China (LR18C200002) , National Natural Science
   Foundation of China, China (U1703105) , and the Fundamental Research
   Funds for the Central Universities, China (2017QNA6006) . We thank
   Zhejiang Huibao Biotechnology Co., Ltd for preparing the original pulp
   of sea buckthorn juice and the fermented sea buckthorn juice.
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NR 43
TC 15
Z9 17
U1 10
U2 115
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0963-9969
EI 1873-7145
J9 FOOD RES INT
JI Food Res. Int.
PD DEC
PY 2022
VL 162
AR 111948
DI 10.1016/j.foodres.2022.111948
EA SEP 2022
PN A
PG 13
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA 5K0SO
UT WOS:000869444500005
PM 36461283
DA 2025-06-11
ER

PT J
AU Gantenbein, KV
   Kanaka-Gantenbein, C
AF Gantenbein, Katherina V.
   Kanaka-Gantenbein, Christina
TI Mediterranean Diet as an Antioxidant: The Impact on Metabolic Health and
   Overall Wellbeing
SO NUTRIENTS
LA English
DT Review
DE Mediterranean diet; antioxidation; metabolic health; reproductive
   health; gut microbiota; non-communicable diseases; flavonoids;
   polyphenols; resveratrol; olive oil
ID POLYCYSTIC-OVARY-SYNDROME; GLYCATION END-PRODUCTS; FATTY LIVER-DISEASE;
   CARDIOVASCULAR-DISEASE; INSULIN-RESISTANCE; GUT MICROBIOTA;
   GLUCOSE-UPTAKE; INFLAMMATION; POLYPHENOLS; QUERCETIN
AB It has been established, worldwide, that non-communicable diseases such as obesity, diabetes, metabolic syndrome, and cardiovascular events account for a high percentage of morbidity and mortality in contemporary societies. Several modifiable risk factors, such as sedentary activities, sleep deprivation, smoking, and unhealthy dietary habits have contributed to this increase. Healthy nutrition in terms of adherence to the Mediterranean diet (MD), rich in fruits, legumes, vegetables, olive oil, herbs, spices, and high fiber intake may contribute to the decrease in this pandemic. The beneficial effects of the MD can be mainly attributed to its numerous components rich in anti-inflammatory and antioxidant properties. Moreover, the MD may further contribute to the improvement of reproductive health, modify the risk for neurodegenerative diseases, and protect against depression and psychosocial maladjustment. There is also evidence highlighting the impact of healthy nutrition in female people on the composition of the gut microbiota and future metabolic and overall health of their offspring. It is therefore important to highlight the beneficial effects of the MD on metabolic, reproductive, and mental health, while shaping the overall health of future generations. The beneficial effects of MD can be further enhanced by increased physical activity in the context of a well-balanced healthy lifestyle.
C1 [Gantenbein, Katherina V.; Kanaka-Gantenbein, Christina] Natl & Kapodistrian Univ Athens, Sch Med, Aghia Sophia Childrens Hosp, Div Endocrinol Diabet & Metab,Dept Pediat 1, Athens 11527, Greece.
C3 Athens Medical School; The Aghia Sophia Children's Hospital; National &
   Kapodistrian University of Athens
RP Kanaka-Gantenbein, C (corresponding author), Natl & Kapodistrian Univ Athens, Sch Med, Aghia Sophia Childrens Hosp, Div Endocrinol Diabet & Metab,Dept Pediat 1, Athens 11527, Greece.
EM katherina.ganten@gmail.com; chriskan@med.uoa.gr
RI Kanaka-Gantenbein, Christina/AAP-3697-2020
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NR 130
TC 166
Z9 169
U1 19
U2 66
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JUN
PY 2021
VL 13
IS 6
AR 1951
DI 10.3390/nu13061951
PG 18
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA SY9QD
UT WOS:000666212700001
PM 34204057
OA gold, Green Published
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Nazari, H
   Sabaghi, A
   Nedaei, E
   Yousofvand, N
AF Nazari, Hossein
   Sabaghi, Ayoob
   Nedaei, Ershad
   Yousofvand, Namdar
TI Differential impacts of high-intensity interval training and
   moderate-intensity continuous training on obesity-induced behavioral and
   biochemical dysregulation in male mice
SO SPORT SCIENCES FOR HEALTH
LA English
DT Article; Early Access
DE Aerobic exercise; High-fat diet; Sociability; Anxiety; Mice
ID METABOLIC SYNDROME; OXIDATIVE STRESS; EXERCISE; ACID
AB Purpose The rising prevalence of obesity, largely due to high-fat diets (HFD), is associated with the onset of various behavioral and physiologic disorders, including increased anxiety, inflammation, and insulin resistance (IR). Aerobic exercise (AE) has shown promise in ameliorating these adverse effects. This study aims to compare the efficacy of high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) in improving obesity-induced anxiety, social deficits, and biochemical markers such as interleukin-1 beta (IL-1 beta), corticosterone (CORT), and peripheral IR in male mice. Methods Forty four-week-old male C57BL/6 mice were assigned to one of two dietary groups: normal diet (CTRL, n = 10) or high-fat diet (HFD, n = 30). The HFD group was further subdivided into three experimental conditions: HFD (n = 10), HFD + MICT (n = 10), and HFD + HIIT (n = 10). Results HFD consumption led to significant behavioral alterations, including reduced social preference (p < 0.001) and increased anxiety levels (p < 0.05 in the open arm, p < 0.001 in the closed arm). Both HIIT and MICT alleviated these negative effects (p < 0.001 in social preference and closed arm, p < 0.05 in open arm). In addition, AE significantly reduced inflammatory cytokine IL-1 beta, CORT, and peripheral IR levels, all elevated by HFD consumption (p < 0.001). Although HIIT demonstrated a slightly more pronounced effect on reducing anxiety and behavioral deficits compared to MICT, this difference was not statistically significant (p > 0.05). Conclusion These findings indicate that both HIIT and MICT effectively mitigate obesity-induced behavioral and physiologic impairments, particularly through the reduction of IL-1 beta, CORT, and peripheral IR levels. This study highlights the potential of structured AE to alleviate the neurobehavioral and physiologic dysregulation associated with obesity, underscoring its relevance in addressing the growing obesity epidemic.
C1 [Nazari, Hossein; Yousofvand, Namdar] Razi Univ, Fac Sci, Dept Biol, Kermanshah, Iran.
   [Sabaghi, Ayoob] Razi Univ, Dept Sport Sci, Kermanshah, Iran.
   [Nedaei, Ershad] Kermanshah Univ Med Sci, Dept Physiol, Kermanshah, Iran.
C3 Razi University; Razi University; Kermanshah University of Medical
   Sciences
RP Yousofvand, N (corresponding author), Razi Univ, Fac Sci, Dept Biol, Kermanshah, Iran.
EM yousofnam@yahoo.com
RI Yousofvand, Namdar/HPB-7343-2023
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NR 68
TC 0
Z9 0
U1 2
U2 2
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 1824-7490
EI 1825-1234
J9 SPORT SCI HLTH
JI Sport Sci. Health
PD 2025 APR 4
PY 2025
DI 10.1007/s11332-025-01384-z
EA APR 2025
PG 10
WC Sport Sciences
WE Emerging Sources Citation Index (ESCI)
SC Sport Sciences
GA 0ZO7U
UT WOS:001459770400001
DA 2025-06-11
ER

PT J
AU Ramos, ELL
   Lima, MFC
   Azevedo, ACSF
   Lopes, MGF
   Moreira, APB
   Souza, CT
AF Ramos, E. L. L.
   Lima, M. F. C.
   Azevedo, A. C. S. F.
   Lopes, M. G. F.
   Moreira, A. P. B.
   Souza, C. T.
TI Effects of diets rich in monounsaturated fatty acids on the management
   and prevention of insulin resistance: A systematic review
SO GRASAS Y ACEITES
LA English
DT Review
DE Metabolic syndrome; Monounsaturated fatty acids; Obesity; Systematic
   review
ID CARDIOVASCULAR RISK-FACTORS; VIRGIN OLIVE OIL; MEDITERRANEAN DIET;
   METABOLIC SYNDROME; OXIDATIVE STRESS; IMPACT; PEOPLE; CARBOHYDRATE;
   ASSOCIATION; CONSUMPTION
AB Insulin resistance (IR), which is linked to obesity, is a mechanism associated with metabolic diseases, mainly type 2 diabetes mellitus. Studies have shown that monounsaturated fatty acids (MUFAs) have anti-inflammatory and anti-oxidative properties which positively affect IR. This systematic review examined the effects of MUFAs from different sources on IR in obese or overweight patients with or without metabolic syndrome. A search was carried out in the PubMed/Medline and Bireme/VHL databases, and data from 16 studies were analysed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The intervention time ranged from 1 day to 5.2 years. All participants were overweight or obese; some had central obesity, a moderate risk of cardiovascular disease, low high-density lipoprotein levels, altered fasting glucose levels, prediabetes or type 2 diabetes mellitus. This systematic review provides evidence that MUFA-rich diets can improve IR.
C1 [Ramos, E. L. L.; Lima, M. F. C.; Azevedo, A. C. S. F.; Lopes, M. G. F.; Souza, C. T.] Univ Fed Juiz de Fora, Med Sch, Res Ctr Nutr & Phys Exercise Appl Metab Syndrome, Juiz De Fora, Brazil.
   [Moreira, A. P. B.] Univ Fed Juiz de Fora, Biol Sci Inst, Dept Nutr, Juiz De Fora, Brazil.
C3 Universidade Federal de Juiz de Fora; Universidade Federal de Juiz de
   Fora
RP Souza, CT (corresponding author), Univ Fed Juiz de Fora, Med Sch, Res Ctr Nutr & Phys Exercise Appl Metab Syndrome, Juiz De Fora, Brazil.
EM claudio.teodoro@ufjf.edu.br
RI RAMOS, ELIEZER/M-4105-2017
OI Guedes Fraga Lopes, Marina/0000-0003-4035-8448; Cardoso de Lima, Mario
   Flavio/0000-0002-5735-4411
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NR 43
TC 0
Z9 0
U1 0
U2 1
PU CONSEJO SUPERIOR INVESTIGACIONES CIENTIFICAS-CSIC
PI MADRID
PA Editorial CSIC, C/VITRUVIO 8, 28006 MADRID, SPAIN
SN 0017-3495
EI 1988-4214
J9 GRASAS ACEITES
JI Grasas Aceites
PD JUL-SEP
PY 2023
VL 74
IS 3
AR e522
DI 10.3989/gya.1125212
PG 10
WC Chemistry, Applied; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Food Science & Technology
GA GK5Y1
UT WOS:001152588300012
OA gold
DA 2025-06-11
ER

PT J
AU Toton-Zuranska, J
   Balazova, L
   Krskova, K
   Bujak-Gizycka, B
   Zorad, S
   Olszanecki, R
   Suski, M
AF Toton-Zuranska, Justyna
   Balazova, Lucia
   Krskova, Katarina
   Bujak-Gizycka, Beata
   Zorad, Stefan
   Olszanecki, Rafal
   Suski, Maciej
TI Plasma proteome alterations in prediabetic, obese Zucker rats - possible
   cardiovascular risk implications
SO GENERAL PHYSIOLOGY AND BIOPHYSICS
LA English
DT Article
DE Obesity; Metabolic syndrome; Thrombophilia; Inflammation; Proteomics
ID APOLIPOPROTEIN-A-IV; INSULIN-RESISTANCE; THROMBUS FORMATION; METABOLIC
   SYNDROME; ENERGY HOMEOSTASIS; HEPATIC STEATOSIS; OXIDATIVE STRESS;
   ADIPOSE-TISSUE; FOOD-INTAKE; WEIGHT-LOSS
AB Hyperphagia and obesity, which underlie metabolic syndrome, have been linked to multiple health complications and increased mortality. Here, we investigate the differences in plasma proteome between obese and lean Zucker rats in order to identify circulating proteins involved in obesity-related conditions. Plasma samples of male Zucker fatty (obese) rats carrying fatty fa/fa mutation (-/-) and their lean controls were enriched using ProteoMiner technology and labeled with isobaric tags (iTRAQ) for mass spectrometry-based quantitation. We found elevation in levels of coagulation factors whereas levels of serine protease inhibitors were decreased. Levels of acute phase proteins were also altered, as well as complement components. We also noticed differences in the abundance of apolipoproteins. In summary, quantitative proteomic assessment of plasma protein composition in obese Zucker rats revealed a profound landscape of changes, reflecting altered hemostasis, disturbed metabolic processes involving insulin resistance and lipid metabolism and ongoing low-grade inflammation.
C1 [Toton-Zuranska, Justyna] Jagiellonian Univ, Med Coll, Ctr Med Genom OMICRON, Krakow, Poland.
   [Balazova, Lucia; Krskova, Katarina; Zorad, Stefan] Slovak Acad Sci, Inst Expt Endocrinol, Biomed Res Ctr, Bratislava, Slovakia.
   [Bujak-Gizycka, Beata; Olszanecki, Rafal; Suski, Maciej] Jagiellonian Univ, Med Coll, Fac Med, Krakow, Poland.
C3 Jagiellonian University; Collegium Medicum Jagiellonian University;
   Slovak Academy of Sciences; Biomedical Research Center, SAS; Institute
   of Experimental Endocrinology, SAS; Jagiellonian University; Collegium
   Medicum Jagiellonian University
RP Suski, M (corresponding author), 16 Grzegorzecka Str, PL-31531 Krakow, Poland.
EM maciej.suski@uj.edu.pl
RI Balazova, Lucia/Y-6371-2019; Suski, Maciej/CAE-9614-2022
OI Balazova, Lucia/0000-0001-6765-7486; Suski, Maciej/0000-0001-7575-2184
FU Scientific Grant Agency of the Ministry of Education, Science, Research
   and Sport of the Slovak Republic; Slovak Academy of Sciences [VEGA
   2/0160/20]; Slovak Research and Development Agency APVV [APVV-15-0229]
FX This study was supported by Scientific Grant Agency of the Ministry of
   Education, Science, Research and Sport of the Slovak Republic and the
   Slovak Academy of Sciences (VEGA 2/0160/20) and by the Slovak Research
   and Development Agency APVV (APVV-15-0229).
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NR 82
TC 0
Z9 0
U1 1
U2 5
PU AEPRESS SRO
PI BRATISLAVA
PA BAJZOVA 7, BRATISLAVA, 821 08, SLOVAKIA
SN 0231-5882
EI 1338-4325
J9 GEN PHYSIOL BIOPHYS
JI Gen. Physiol. Biophys.
PY 2022
VL 41
IS 6
BP 549
EP 558
DI 10.4149/gpb_2022043
PG 10
WC Biochemistry & Molecular Biology; Biophysics; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Physiology
GA D9RV8
UT WOS:000972038500006
PM 36454115
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Chang, KJ
   Lin, JA
   Chen, SY
   Weng, MH
   Yen, GC
AF Chang, Kai-Jyun
   Lin, Jer-An
   Chen, Sheng-Yi
   Weng, Ming-Hung
   Yen, Gow-Chin
TI Silymarin protects against high fat diet-evoked metabolic injury by
   induction of glucagon-like peptide 1 and sirtuin 1
SO JOURNAL OF FUNCTIONAL FOODS
LA English
DT Article
DE High fat diet; Silymarin; Metabolic syndrome; GLP-1; Sirt1
ID INSULIN-RESISTANCE; OXIDATIVE STRESS; FLAVONOID INTAKE; LIVER-DISEASE;
   RISK-FACTOR; OBESITY; INFLAMMATION; SILIBININ; GLP-1; BIOAVAILABILITY
AB High-fat diet (HFD) is one of the major causes of increased prevalence of the metabolic syndrome. In this study, effect of silymarin on prevention and improvement of metabolic injury in HFD-induced rats was assessed. Results showed that silymarin intervention from 0 week or 8th week of the time course in the experiment significantly improved metabolic syndromes, including insulin resistance and dyslipidemia in high fat diet-treated rats. Silymarin also can ameliorate the HFD-impaired glucose tolerance and recover, further enhance HFD-impaired glucagon-like peptide 1 (GLP-1) secretion in these rats. Intervention of silymarin from 0 week can prevent HFD-induced hepatic steatosis, pancreas fibrosis, and decreased sirtuin 1 protein levels of pancreas and liver in rats. In conclusion, silymarin can prevent and ameliorate HFD-induced metabolic syndrome, as well as improvement of GLP-1 secretion and Sirt1 protein expression, suggesting that silymarin may be a potential food factor against metabolic injury.
C1 [Chang, Kai-Jyun; Chen, Sheng-Yi; Weng, Ming-Hung; Yen, Gow-Chin] Natl Chung Hsing Univ, Dept Food Sci & Biotechnol, 145 Xingda Rd, Taichung 40227, Taiwan.
   [Lin, Jer-An; Yen, Gow-Chin] Natl Chung Hsing Univ, Grad Inst Food Safety, 145 Xingda Rd, Taichung 40227, Taiwan.
C3 National Chung Hsing University; National Chung Hsing University
RP Yen, GC (corresponding author), Natl Chung Hsing Univ, Dept Food Sci & Biotechnol, 145 Xingda Rd, Taichung 40227, Taiwan.
EM gcyen@nchu.edu.tw
RI Yen, Gow-Chin/B-7886-2009; Lin, Jer-An/O-1576-2015
OI Lin, Jer-An/0000-0002-1362-1370; Yen, Gow-Chin/0000-0001-9538-4219
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NR 50
TC 7
Z9 8
U1 0
U2 15
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1756-4646
J9 J FUNCT FOODS
JI J. Funct. Food.
PD MAY
PY 2019
VL 56
BP 136
EP 144
DI 10.1016/j.jff.2019.03.012
PG 9
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA HX6IN
UT WOS:000467507400016
DA 2025-06-11
ER

PT J
AU Kanbay, M
   Jensen, T
   Solak, Y
   Le, M
   Roncal-Jimenez, C
   Rivard, C
   Lanaspa, MA
   Nakagawa, T
   Johnson, RJ
AF Kanbay, Mehmet
   Jensen, Thomas
   Solak, Yalcin
   Le, Myphuong
   Roncal-Jimenez, Carlos
   Rivard, Chris
   Lanaspa, Miguel A.
   Nakagawa, Takahiko
   Johnson, Richard J.
TI Uric acid in metabolic syndrome: From an innocent bystander to a central
   player
SO EUROPEAN JOURNAL OF INTERNAL MEDICINE
LA English
DT Review
DE Uric acid; Metabolic syndrome; Hypertension; Diabetes mellitus; Kidney
   disease; Cardiovascular disease
ID FATTY LIVER-DISEASE; GLUCOSE-SWEETENED BEVERAGES;
   MUSCLE-CELL-PROLIFERATION; CHRONIC KIDNEY-DISEASE; BLOOD-PRESSURE;
   OXIDATIVE STRESS; CARDIOVASCULAR-DISEASE; ENDOTHELIAL DYSFUNCTION;
   NITRIC-OXIDE; RISK-FACTORS
AB Uric acid, once viewed as an inert metabolic end-product of purinemetabolism, has been recently incriminated in a number of chronic disease states, including hypertension, metabolic syndrome, diabetes, non- alcoholic fatty liver disease, and chronic kidney disease. Several experimental and clinical studies support a role for uric acid as a contributory causal factor in these conditions. Here we discuss some of the major mechanisms linking uric acid to metabolic and cardiovascular diseases. At this time the key to understanding the importance of uric acid in these diseases will be the conduct of large clinical trials in which the effect of lowering uric acid on hard clinical outcomes is assessed. Elevated uric acid may turn out to be one of the more important remediable risk factors for metabolic and cardiovascular diseases. (C) 2015 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.
C1 [Kanbay, Mehmet] Koc Univ, Sch Med, Dept Med, Div Nephrol, Istanbul, Turkey.
   [Jensen, Thomas; Le, Myphuong; Roncal-Jimenez, Carlos; Rivard, Chris; Lanaspa, Miguel A.; Johnson, Richard J.] Univ Colorado, Div Renal Dis & Hypertens, Aurora, CO USA.
   [Solak, Yalcin] Sakarya Training & Res Hosp, Dept Med, Div Nephrol, Sakarya, Turkey.
   [Nakagawa, Takahiko] Kyoto Univ, TMK Project, Med Innovat Ctr, Kyoto, Japan.
   [Johnson, Richard J.] Eastern Colorado Hlth Care Syst, Div Nephrol, Dept Vet Affairs, Denver, CO USA.
C3 Koc University; University of Colorado System; University of Colorado
   Anschutz Medical Campus; Sakarya Training & Research Hospital; Kyoto
   University
RP Kanbay, M (corresponding author), Koc Univ, Sch Med, Dept Med, Div Nephrol, Istanbul, Turkey.
EM mkanbay@ku.edu.tr
RI 1, 1/L-6277-2019; Solak, Yalcin/AAD-1393-2020; Lanaspa,
   Miguel/AAO-4971-2020
OI Le, MyPhuong/0000-0002-1136-3419
FU NIDDK NIH HHS [K01 DK095930, R03 DK105041] Funding Source: Medline
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NR 116
TC 296
Z9 314
U1 20
U2 222
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0953-6205
EI 1879-0828
J9 EUR J INTERN MED
JI Eur. J. Intern. Med.
PD APR
PY 2016
VL 29
BP 3
EP 8
DI 10.1016/j.ejim.2015.11.026
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA DI7YV
UT WOS:000373718800013
PM 26703429
OA Green Accepted
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Angoorani, P
   Ejtahed, HS
   Mirmiran, P
   Mirzaei, S
   Azizi, F
AF Angoorani, Pooneh
   Ejtahed, Hanieh-Sadat
   Mirmiran, Parvin
   Mirzaei, Sahar
   Azizi, Fereidoun
TI Dietary consumption of advanced glycation end products and risk of
   metabolic syndrome
SO INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION
LA English
DT Article
DE Abdominal obesity; dietary AGEs; hypertriglyceridemia; metabolic
   syndrome; obesity
ID OXIDATIVE STRESS; NUTRITION TRANSITION; SOLUBLE RECEPTOR; VISCERAL FAT;
   RAGE; ENDPRODUCTS; QUESTIONNAIRE; GLYCOTOXINS; DISEASE; ACCUMULATION
AB Metabolic syndrome (MetS) is a complex disorder which has become one of the major public health challenges worldwide. This study was conducted to evaluate the association between dietary advanced glycation end products (AGEs) and risk of MetS and its components. This cross-sectional study was conducted in a representative sample of 5848 adults, aged 19-70 years. Daily consumption of carboxymethyl lysine, a major type of AGEs, was determined using a validated semi-quantitative food frequency questionnaire. Across increasing trend of AGEs consumption, the percentage of fat intake increased and that of carbohydrate significantly decreased (p<0.001). Subjects in the highest (>10506 kU/d) compared to the lowest (<6673 kU/d) quartile category of AGEs had higher risk of abdominal obesity (OR: 1.19, 95% CI: 1.01-1.39) and hypertriglyceridemia (OR: 1.26, 95% CI: 1.07-1.49). Therefore, recommendation on restriction of AGEs intake could be a practical approach to prevent metabolic abnormalities.
C1 [Angoorani, Pooneh; Mirmiran, Parvin; Mirzaei, Sahar] Shahid Beheshti Univ Med Sci, Nutr & Endocrine Res Ctr, Res Inst Endocrine Sci, Box 19395-4741, Tehran, Iran.
   [Ejtahed, Hanieh-Sadat] Univ Tehran Med Sci, Endocrinol & Metab Mol Cellular Sci Inst, Obes & Eating Habits Res Ctr, Tehran, Iran.
   [Ejtahed, Hanieh-Sadat] Univ Tehran Med Sci, Endocrinol & Metab Res Ctr, Endocrinol & Metab Clin Sci Inst, Tehran, Iran.
   [Mirmiran, Parvin] Shahid Beheshti Univ Med Sci, Natl Nutr & Food Technol Res Inst, Fac Nutr Sci & Food Technol, Dept Clin Nutr & Dietet, Tehran, Iran.
   [Azizi, Fereidoun] Shahid Beheshti Univ Med Sci, Res Inst Endocrine Sci, Endocrine Res Ctr, Tehran, Iran.
C3 Shahid Beheshti University Medical Sciences; Tehran University of
   Medical Sciences; Tehran University of Medical Sciences; Shahid Beheshti
   University Medical Sciences; Shahid Beheshti University Medical Sciences
RP Mirmiran, P (corresponding author), Shahid Beheshti Univ Med Sci, Nutr & Endocrine Res Ctr, Res Inst Endocrine Sci, Box 19395-4741, Tehran, Iran.
EM mirmiran@endocrine.ac.ir
RI ejtahed, hanieh/AAH-4921-2021; Mirmiran, Parvin/V-1433-2019; Azizi,
   Fereidoun/ABD-4136-2021
OI Ejtahed, Hanieh-Sadat/0000-0002-6395-4915; Mirmiran,
   Parvin/0000-0003-2391-4924; Azizi, Fereidoun/0000-0002-6470-2517
FU Research Institute for Endocrine Sciences, Shahid Beheshti University of
   Medical Sciences, Islamic Republic of Iran
FX This work was funded by the Research Institute for Endocrine Sciences,
   Shahid Beheshti University of Medical Sciences, Islamic Republic of
   Iran.
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NR 48
TC 49
Z9 52
U1 0
U2 16
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0963-7486
EI 1465-3478
J9 INT J FOOD SCI NUTR
JI Int. J. Food Sci. Nutr.
PD FEB 17
PY 2016
VL 67
IS 2
BP 170
EP 176
DI 10.3109/09637486.2015.1137889
PG 7
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA DG1EY
UT WOS:000371809600011
PM 26850840
DA 2025-06-11
ER

PT J
AU Laurencin, MG
   Goldschmidt, R
   Fisher, L
AF Laurencin, M. Grace
   Goldschmidt, Ronald
   Fisher, Lawrence
TI Type 2 diabetes in adolescents - How to recognize and treat this growing
   problem
SO POSTGRADUATE MEDICINE
LA English
DT Article
ID METABOLIC SYNDROME; CHILDREN; MELLITUS; FAMILY; DEPRESSION; PREVALENCE;
   CHILDHOOD; EPIDEMIC; DISEASE; TIME
AB At the same time they are reporting the current obesity epidemic, US physicians are also seeing a dramatic increase in the prevalence of type 2 diabetes in adolescent patients. In this article, Drs Laurencin, Gold-schmidt, and Fisher summarize the prevalence and risk factors, clinical presentation, diagnosis, and treatment of type 2 diabetes in adolescents. They also offer interventional strategies for both lifestyle change and pharmacologic management.
C1 [Laurencin, M. Grace; Goldschmidt, Ronald; Fisher, Lawrence] Univ Calif San Francisco, Sch Med, Dept Family & Community Med, San Francisco, CA 94143 USA.
C3 University of California System; University of California San Francisco
RP Laurencin, MG (corresponding author), Univ Calif San Francisco, Sch Med, Dept Family & Community Med, 500 Parnassus Ave,Box 0900, San Francisco, CA 94143 USA.
EM mgralaur@cruzio.com
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NR 24
TC 4
Z9 4
U1 0
U2 1
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0032-5481
EI 1941-9260
J9 POSTGRAD MED
JI Postgrad. Med.
PD NOV
PY 2005
VL 118
IS 5
BP 31
EP +
DI 10.3810/pgm.2005.11.1685
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA V44DQ
UT WOS:000202983800003
PM 16329529
DA 2025-06-11
ER

PT J
AU Satish, M
   Saxena, SK
   Agrawal, DK
AF Satish, Mohan
   Saxena, Shailendra K.
   Agrawal, Devendra K.
TI Adipokine Dysregulation and Insulin Resistance with Atherosclerotic
   Vascular Disease: Metabolic Syndrome or Independent Sequelae?
SO JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
LA English
DT Review
DE Adipokines; Atherosclerosis; Endothelial dysfunction; Inflammation;
   Insulin resistance; Metabolic syndrome
ID NECROSIS-FACTOR-ALPHA; PROTEIN-KINASE-C; ENDOTHELIAL DYSFUNCTION;
   ADIPOSE-TISSUE; NITRIC-OXIDE; CARDIOVASCULAR-DISEASE; ACTIVATOR
   INHIBITOR-1; CAROTID BIFURCATION; OXIDATIVE STRESS; GROWTH-FACTOR
AB Adipokine dysregulation and insulin resistance are two hallmark sequelae attributed to the current clinical definition of metabolic syndrome (MetS) that are also linked to atherosclerotic vascular disease. Here, we critically discuss the underlying pathophysiological mechanisms and the interplay between the two sequelae. Adipokine dysregulation is involved with decreased nitric oxide, vascular inflammation, and insulin resistance in itself to promote atherosclerosis. Insulin resistance is involved with endothelial dysfunction by direct and indirect mechanisms that also promote vascular inflammation and atherosclerosis. These mechanisms are discussed in atherosclerosis irrespective of MetS, and to evaluate the possibility of synergism in MetS. High retinol-binding protein-4 (RBP-4) and low cholesterol efflux in MetS may provide evidence of possible synergism and elevated atherosclerotic risk. An adverse adipokine panel that includes fetuin-A and adiponectin can potentially assess atherosclerotic risk in even those without MetS. Genetic possibilities may exist in atherosclerotic vascular diseases secondary to insulin resistance.
C1 [Satish, Mohan; Agrawal, Devendra K.] Creighton Univ, Sch Med, Peekie Nash Carpenter Endowed Chair Med, Dept Clin & Translat Sci, CRISS II Room 510,2500 Calif Plaza, Omaha, NE 68178 USA.
   [Saxena, Shailendra K.] Creighton Univ, Sch Med, Dept Family Med, Omaha, NE 68178 USA.
C3 Creighton University; Creighton University
RP Agrawal, DK (corresponding author), Creighton Univ, Sch Med, Peekie Nash Carpenter Endowed Chair Med, Dept Clin & Translat Sci, CRISS II Room 510,2500 Calif Plaza, Omaha, NE 68178 USA.
EM dkagr@creighton.edu
RI Saxena, Shailendra K/ABK-6489-2022; Agrawal, Devendra/GLR-3925-2022
OI Satish, Mohan/0000-0003-3567-8877; Agrawal, Devendra/0000-0001-5445-0013
FU National Institutes of Health, USA [R01HL120659, R01HL144125]
FX The research work of DK Agrawal is supported by research grants
   R01HL120659 and R01HL144125 from the National Institutes of Health, USA.
   The content of this review article is solely the responsibility of the
   authors and does not necessarily represent the official views of the
   National Institutes of Health.
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NR 85
TC 20
Z9 21
U1 0
U2 5
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1937-5387
EI 1937-5395
J9 J CARDIOVASC TRANSL
JI J. Cardiovasc. Transl. Res.
PD OCT
PY 2019
VL 12
IS 5
BP 415
EP 424
DI 10.1007/s12265-019-09879-0
PG 10
WC Cardiac & Cardiovascular Systems; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Research & Experimental Medicine
GA JP0JX
UT WOS:000497959200004
PM 30835048
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Nduhirabandi, F
   du Toit, EF
   Lochner, A
AF Nduhirabandi, F.
   du Toit, E. F.
   Lochner, A.
TI Melatonin and the metabolic syndrome: a tool for effective therapy in
   obesity-associated abnormalities?
SO ACTA PHYSIOLOGICA
LA English
DT Review
DE cardiovascular effects; insulin resistance; leptin resistance;
   melatonin; metabolic syndrome; obesity
ID DIET-INDUCED OBESITY; HIGH-FAT DIET; ACUTE MYOCARDIAL-INFARCTION;
   BODY-WEIGHT REGULATION; TYPE-2 DIABETIC-RATS; SPRAGUE-DAWLEY RATS;
   GOTO-KAKIZAKI RATS; OXIDATIVE STRESS; ISCHEMIA-REPERFUSION;
   CARDIOVASCULAR-DISEASE
AB The metabolic syndrome (MetS) is a cluster of metabolic abnormalities associated with increased risk for cardiovascular diseases. Apart from its powerful antioxidant properties, the pineal gland hormone melatonin has recently attracted the interest of various investigators as a multifunctional molecule. Melatonin has been shown to have beneficial effects in cardiovascular disorders including ischaemic heart disease and hypertension. However, its role in cardiovascular risk factors including obesity and other related metabolic abnormalities is not yet established, particularly in humans. New emerging data show that melatonin may play an important role in body weight regulation and energy metabolism. This review will address the role of melatonin in the MetS focusing on its effects in obesity, insulin resistance and leptin resistance. The overall findings suggest that melatonin should be exploited as a therapeutic tool to prevent or reverse the harmful effects of obesity and its related metabolic disorders.
C1 [Nduhirabandi, F.; Lochner, A.] Univ Stellenbosch, Div Med Physiol, Dept Biomed Sci, Fac Hlth Sci, ZA-7600 Stellenbosch, South Africa.
   [du Toit, E. F.] Griffith Univ, Sch Med Sci, Southport, Qld 4215, Australia.
C3 Stellenbosch University; Griffith University; Griffith University - Gold
   Coast Campus
RP Lochner, A (corresponding author), Fac Hlth Sci, Dept Biomed Sci, POB 19063, ZA-7505 Tygerberg, South Africa.
EM alo@sun.ac.za
RI Nduhirabandi, Frederic/M-6274-2018
OI Nduhirabandi, Frederic/0000-0002-0428-1220
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NR 162
TC 92
Z9 94
U1 0
U2 20
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1748-1708
EI 1748-1716
J9 ACTA PHYSIOL
JI Acta Physiol.
PD JUN
PY 2012
VL 205
IS 2
BP 209
EP 223
DI 10.1111/j.1748-1716.2012.02410.x
PG 15
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA 930CU
UT WOS:000303115100004
PM 22226301
OA Green Published
DA 2025-06-11
ER

PT J
AU Simmons, R
AF Simmons, R
TI Developmental origins of adult metabolic disease: concepts and
   controversies
SO TRENDS IN ENDOCRINOLOGY AND METABOLISM
LA English
DT Review
ID LOW-BIRTH-WEIGHT; INTRAUTERINE GROWTH-RETARDATION; INSULIN-RESISTANCE
   SYNDROME; FOR-GESTATIONAL-AGE; CHILDHOOD GROWTH; BLOOD-PRESSURE;
   MATERNAL UNDERNUTRITION; GLUCOSE-TOLERANCE; OXIDATIVE STRESS; FETAL
AB The 'thrifty phenotype' hypothesis proposes that the fetus adapts to an adverse intrauterine milieu by optimizing the use of a reduced nutrient supply to ensure survival. However, favoring the development of some organs over that of others leads to persistent alterations in the growth and function of developing tissues. Although this concept has been somewhat controversial, recent epidemiological, clinical and animal studies provide support for the developmental origins of disease hypothesis. Underlying mechanisms include reprogramming of the hypothalamic-pituitary-adrenal axis, islet development and insulin-signaling pathways. Emerging data indicates that epigenetic regulation of gene expression might also play a crucial role in the pathogenesis of type 2 diabetes in individuals who are growth retarded at birth.
C1 Childrens Hosp Philadelphia, Dept Pediat, Philadelphia, PA 19104 USA.
   Univ Penn, Philadelphia, PA 19104 USA.
C3 University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of
   Philadelphia; University of Pennsylvania
RP Childrens Hosp Philadelphia, Dept Pediat, Philadelphia, PA 19104 USA.
EM rsimmons@mail.med.upenn.edu
OI Simmons, Rebecca/0000-0002-2901-8904
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NR 56
TC 80
Z9 90
U1 0
U2 8
PU ELSEVIER SCIENCE LONDON
PI LONDON
PA 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND
SN 1043-2760
EI 1879-3061
J9 TRENDS ENDOCRIN MET
JI Trends Endocrinol. Metab.
PD OCT
PY 2005
VL 16
IS 8
BP 390
EP 394
DI 10.1016/j.tem.2005.08.004
PG 5
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 976ND
UT WOS:000232739400008
PM 16118054
DA 2025-06-11
ER

PT J
AU Robson, D
   Haddad, M
AF Robson, Debbie
   Haddad, Mark
TI Mental health nurses' attitudes towards the physical health care of
   people with severe and enduring mental illness: The development of a
   measurement tool
SO INTERNATIONAL JOURNAL OF NURSING STUDIES
LA English
DT Article
DE Attitudes; Mental; Nursing; Physical; Reliability; Validity
ID CARDIOVASCULAR RISK; METABOLIC SYNDROME; RELATIVE RISK; SCHIZOPHRENIA;
   ANTIPSYCHOTICS; MORTALITY
AB Background: It is well established that people with schizophrenia and related serious mental illnesses die prematurely and have significantly higher medical co-morbidity compared with the general population. Mental health nurses have a key role in improving the physical health of patients but their attitudes to this aspect of their role have not been systematically examined.
   Objectives: To develop and validate a measure of mental nurses' attitudes towards physical health care.
   Design: The measurement tool was developed from a literature review, focus groups and responses to a postal questionnaire.
   Participants and setting: All registered nursing staff working within a NHS mental health trust in the UK were sent the questionnaire and 585 (52%) staff responded.
   Methods: Completed questionnaires were analysed by standard descriptive statistical methods. Exploratory factor analysis (principal component analysis) was used to examine and reduce attitude items to a coherent and parsimonious scale.
   Results: A 28-item measure comprised of four factors accounted for 42% of the variance. The factor solution appeared to provide meaningful dimensions, and the internal consistency of the measure and of its derived subscales was adequate (Cronbach's alpha between 0.76 and 0.61). The factors were labelled nurses' attitudes to involvement in physical health care; nurses' confidence in delivering physical health care; perceived barriers to physical health care delivery and nurses' attitudes to smoking. Validity was established by associations between the total scale and subscales with pre-determined respondent variables.
   Conclusion: The Physical Health Attitude Scale for mental health nurses (PHASe) is a first attempt to develop a valid and reliable measure of this important area. The initial development methods and its testing in a large sample provide indications of content and construct validity. Further testing in different samples and consequent refinement are necessary, however the PHASe appears to be a useful tool for measuring attitudes among this professional group and evaluating the effects of professional development. (C) 2011 Elsevier Ltd. All rights reserved.
C1 [Robson, Debbie; Haddad, Mark] Kings Coll London, Hlth Serv & Populat Res Dept, Inst Psychiat, London, England.
   [Haddad, Mark] S London & Maudsley NHS Fdn Trust, London, England.
C3 University of London; King's College London; South London & Maudsley NHS
   Trust
RP Robson, D (corresponding author), Kings Coll London, Hlth Serv & Populat Res Dept, Inst Psychiat, London, England.
EM deborah.robson@kcl.ac.uk; mark.haddad@iop.kcl.ac.uk
RI Robson, Debbie/B-3143-2011; Haddad, Mark/A-9866-2011
OI Robson, Deborah/0000-0002-6447-3523; Haddad, Mark/0000-0002-4822-5482
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NR 50
TC 58
Z9 61
U1 0
U2 16
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0020-7489
EI 1873-491X
J9 INT J NURS STUD
JI Int. J. Nurs. Stud.
PD JAN
PY 2012
VL 49
IS 1
BP 72
EP 83
DI 10.1016/j.ijnurstu.2011.07.011
PG 12
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA 892FV
UT WOS:000300273000009
PM 21899840
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Yoshida, M
AF Yoshida, Masayuki
TI Novel Role of NPC1L1 in the Regulation of Hepatic Metabolism: Potential
   Contribution of Ezetimibe in NAFLD/NASH Treatment
SO CURRENT VASCULAR PHARMACOLOGY
LA English
DT Article
DE NAFLD; NPC1L1; metabolic syndrome; insulin resistance
ID FATTY LIVER-DISEASE; ENDOPLASMIC-RETICULUM; CHOLESTEROL; STEATOSIS;
   INSULIN; STRESS; TRIGLYCERIDE; COMBINATION; ABSORPTION; PREDICTOR
AB Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in Western countries and also in other parts of the world. NAFLD encompasses a histological spectrum ranging from simple steatosis to steatohepatitis, advanced fibrosis and inflammatory changes. It frequently occurs with features of the metabolic syndrome including obesity, type 2 diabetes mellitus, dyslipidemia and hypertension. In fact, the metabolic syndrome is a strong predictor of NAFLD. Recently, Niemann-Pick C1-like 1 (NPC1L1) has been shown to play a pivotal role in cholesterol absorption. Unlike mouse NPC1L1 protein, predominantly expressed in the intestines, human and rat NPC1L1 is also abundantly expressed in the liver. Though the exact functions of hepatic NPC1L1 remain unknown, NPC1L1 may facilitate the hepatic accumulation of cholesterol. This raises a potential possibility that ezetimibe may improve fatty liver formation. In this review, potential role of lipid metabolism in NAFLD and its possible modulation through NPC1L1 blockade is discussed.
C1 Tokyo Med & Dent Univ, Life Sci & Bioeth Res Ctr, Bunkyo Ku, Tokyo 1138519, Japan.
C3 Institute of Science Tokyo; Tokyo Medical & Dental University (TMDU)
RP Yoshida, M (corresponding author), Tokyo Med & Dent Univ, Life Sci & Bioeth Res Ctr, Bunkyo Ku, 1-5-45 Yushima, Tokyo 1138519, Japan.
EM masavasc@tmd.ac.jp
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NR 21
TC 12
Z9 14
U1 0
U2 14
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y26, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1570-1611
J9 CURR VASC PHARMACOL
JI Current Vascular Pharmacology
PD JAN
PY 2011
VL 9
IS 1
BP 121
EP 123
DI 10.2174/157016111793744715
PG 3
WC Pharmacology & Pharmacy; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Cardiovascular System & Cardiology
GA 712HF
UT WOS:000286656200015
PM 21044016
DA 2025-06-11
ER

PT J
AU Korman, N
   Fox, H
   Skinner, T
   Dodd, C
   Suetani, S
   Chapman, J
   Parker, S
   Dark, F
   Collins, C
   Rosenbaum, S
   Siskind, D
AF Korman, Nicole
   Fox, Harley
   Skinner, Tina
   Dodd, Cassandra
   Suetani, Shuichi
   Chapman, Justin
   Parker, Stephen
   Dark, Frances
   Collins, Cheryl
   Rosenbaum, Simon
   Siskind, Dan
TI Feasibility and Acceptability of a Student-Led Lifestyle (Diet and
   Exercise) Intervention Within a Residential Rehabilitation Setting for
   People With Severe Mental Illness, GO HEART (Group Occupation, Health,
   Exercise And Rehabilitation Treatment)
SO FRONTIERS IN PSYCHIATRY
LA English
DT Article
DE severe mental illness; schizophrenia; exercise; diet; rehabilitation;
   lifestyle intervention; physical activity; student placement
ID BEHAVIORAL WEIGHT-LOSS; IMPROVE CARDIOMETABOLIC HEALTH;
   PHYSICAL-ACTIVITY; CARDIORESPIRATORY FITNESS; OBESOGENIC ENVIRONMENT;
   SCHIZOPHRENIA; METAANALYSIS; INDIVIDUALS; RELIABILITY; MEDICATIONS
AB Purpose
   People with severe mental illness (SMI) experience poor physical health and premature mortality, contributed significantly by modifiable lifestyle risk factors such as poor nutrition, low cardiorespiratory fitness, and physical inactivity. Lifestyle interventions can reduce cardiometabolic risk and confer a range of other positive mental and physical health benefits. We assessed the feasibility, acceptability, safety, and preliminary effectiveness of a lifestyle (combined dietary and exercise) intervention lead by senior exercise and dietetics students in a residential mental health rehabilitation setting.
   Design
   Single arm, prospective study evaluating outcomes pre and post a 10-week dietary and exercise intervention.
   Method
   People with SMI from three residential rehabilitation units participated in a mixed aerobic and resistance training exercise intervention three times per week that was combined with a dietary intervention (six individual and group sessions). Primary outcome considerations were feasibility (recruitment, retention, and participation rates), acceptability, and adverse events. Secondary outcomes were preliminary effectiveness; (functional exercise capacity, volume of exercise, and metabolic markers), psychiatric symptoms, quality of life, and attitudes to exercise.
   Results
   Forty-two participants were recruited (92% primary diagnosis of schizophrenia). Intervention feasibility was supported by high levels of recruitment (68%), retention (77%), and participation (70% exercise, 65% diet sessions); and the absence of serious adverse events. Significant improvements in functional exercise capacity, volume of exercise, general psychiatric symptoms, and negative psychotic symptoms occurred. Anthropometric and metabolic blood markers did not change. While the intervention was acceptable to participants, motivation for and perceived value of exercise reduced over 10 weeks.
   Conclusions
   A brief pragmatic student-led lifestyle intervention integrated into usual mental health care was feasible, acceptable, safe, and scalable across two additional mental health residential rehabilitation sites, and resulted in physical and mental health improvements. Increased frequency of dietary sessions and length of dietary intervention may improve metabolic outcomes in the future. People with SMI living in residential rehabilitation units should have access to lifestyle programs to address modifiable lifestyle risk factors. While this brief intervention was feasible and acceptable, this study highlights some of the challenges associated with maintaining motivation for healthy lifestyles for people with SMI. Longer term investigation of real-world lifestyle interventions is warranted, together with additional interventions that may support people with SMI to sustain motivation to address lifestyle factors.
C1 [Korman, Nicole; Dodd, Cassandra; Suetani, Shuichi; Chapman, Justin; Parker, Stephen; Dark, Frances; Siskind, Dan] Metro South Hlth Serv, Addict & Mental Hlth Serv, Brisbane, Qld, Australia.
   [Korman, Nicole; Fox, Harley; Parker, Stephen; Dark, Frances; Siskind, Dan] Univ Queensland, Sch Med, Brisbane, Qld, Australia.
   [Skinner, Tina; Collins, Cheryl] Queensland Univ Technol, Sch Exercise & Nutr Sci, Brisbane, Qld, Australia.
   [Chapman, Justin] Queensland Inst Med Res Mental Hlth & Complex Dis, Brisbane, Qld, Australia.
   [Rosenbaum, Simon] UNSW, Fac Med, Sch Psychiat, Sydney, NSW, Australia.
C3 University of Queensland; Queensland University of Technology (QUT);
   University of New South Wales Sydney
RP Korman, N (corresponding author), Metro South Hlth Serv, Addict & Mental Hlth Serv, Brisbane, Qld, Australia.; Korman, N (corresponding author), Univ Queensland, Sch Med, Brisbane, Qld, Australia.
EM n.korman@uq.edu.au
RI Rosenbaum, Simon/Y-3241-2019; Skinner, Tina/D-5432-2012; Chapman,
   Justin/HLP-9248-2023; Parler, Stephen/D-7830-2013; Skinner,
   Tina/N-6733-2013; Siskind, Dan/A-9812-2014; Chapman, Justin/C-4631-2014
OI Skinner, Tina/0000-0002-5704-2741; Siskind, Dan/0000-0002-2072-9216;
   Rosenbaum, Simon/0000-0002-8984-4941; Chapman,
   Justin/0000-0002-2958-2783; Butler, Cassandra N/0009-0009-1739-2737
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NR 74
TC 15
Z9 15
U1 0
U2 10
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-0640
J9 FRONT PSYCHIATRY
JI Front. Psychiatry
PD APR 28
PY 2020
VL 11
AR 319
DI 10.3389/fpsyt.2020.00319
PG 12
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA LO0OH
UT WOS:000533328900001
PM 32411024
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Shnayder, NA
   Grechkina, VV
   Trefilova, VV
   Efremov, IS
   Dontceva, EA
   Narodova, EA
   Petrova, MM
   Soloveva, IA
   Tepnadze, LE
   Reznichenko, PA
   Al-Zamil, M
   Altynbekova, GI
   Strelnik, AI
   Nasyrova, RF
AF Shnayder, Natalia A. A.
   Grechkina, Violetta V. V.
   Trefilova, Vera V. V.
   Efremov, Ilya S. S.
   Dontceva, Evgenia A. A.
   Narodova, Ekaterina A. A.
   Petrova, Marina M. M.
   Soloveva, Irina A. A.
   Tepnadze, Liia E. E.
   Reznichenko, Polina A. A.
   Al-Zamil, Mustafa
   Altynbekova, Gulnara I. I.
   Strelnik, Anna I. I.
   Nasyrova, Regina F. F.
TI Valproate-Induced Metabolic Syndrome
SO BIOMEDICINES
LA English
DT Review
DE valproic acid; metabolic syndrome; personalized approach; metabolomic;
   metabolome
ID CHEMOATTRACTANT PROTEIN-1 MCP-1; NECROSIS-FACTOR-ALPHA; ACID-BINDING
   PROTEIN; INSULIN-RESISTANCE; SODIUM VALPROATE; NEUROPEPTIDE-Y;
   CARDIOVASCULAR-DISEASE; EPILEPTIC CHILDREN; OXIDATIVE STRESS;
   GENE-EXPRESSION
AB Valproic acid (VPA) and its salts (sodium calcium magnesium and orotic) are psychotropic drugs that are widely used in neurology and psychiatry. The long-term use of VPA increases the risk of developing adverse drug reactions (ADRs), among which metabolic syndrome (MetS) plays a special role. MetS belongs to a cluster of metabolic conditions such as abdominal obesity, high blood pressure, high blood glucose, high serum triglycerides, and low serum high-density lipoprotein. Valproate-induced MetS (VPA-MetS) is a common ADR that needs an updated multidisciplinary approach to its prevention and diagnosis. In this review, we consider the results of studies of blood (serum and plasma) and the urinary biomarkers of VPA-MetS. These metabolic biomarkers may provide the key to the development of a new multidisciplinary personalized strategy for the prevention and diagnosis of VPA-MetS in patients with neurological diseases, psychiatric disorders, and addiction diseases.
C1 [Shnayder, Natalia A. A.; Grechkina, Violetta V. V.; Trefilova, Vera V. V.; Nasyrova, Regina F. F.] VM Bekhterev Natl Med Res Ctr Psychiat & Neurol, Inst Personalized Psychiat & Neurol, Shared Core Facil, St Petersburg 192019, Russia.
   [Shnayder, Natalia A. A.; Dontceva, Evgenia A. A.; Narodova, Ekaterina A. A.; Petrova, Marina M. M.; Soloveva, Irina A. A.; Tepnadze, Liia E. E.; Reznichenko, Polina A. A.] VF Voino Yasenetsky Krasnoyarsk State Med Univ, Shared Core Facil Mol & Cell Technol, Krasnoyarsk 660022, Russia.
   [Trefilova, Vera V. V.] Hosp War Vet, Dept Neurol, St Petersburg 193079, Russia.
   [Efremov, Ilya S. S.] Bashkir State Med Univ, Dept Psychiat & Narcol, Ufa 450008, Russia.
   [Dontceva, Evgenia A. A.] Fed Ctr Neurosurg, Novosibirsk 630087, Russia.
   [Al-Zamil, Mustafa] Peoples Friendship Univ Russia, Fac Continuing Med Educ, Dept Physiotherapy, Moscow 117198, Russia.
   [Altynbekova, Gulnara I. I.] SD Asfendiarov Kazakh Natl Med Univ, Dept Psychiat & Narcol, Alma Ata 050022, Kazakhstan.
   [Strelnik, Anna I. I.; Nasyrova, Regina F. F.] Samara State Med Univ, Int Ctr Educ & Res Neuropsychiat, Samara 443016, Russia.
C3 V.M. Bekhterev National Research Medical Center Psychiatry & Neurology;
   Krasnoyarsk State Medical University; Bashkir State Medical University;
   Peoples Friendship University of Russia; Asfendiyarov Kazakh National
   Medical University; Samara State Medical University
RP Shnayder, NA; Nasyrova, RF (corresponding author), VM Bekhterev Natl Med Res Ctr Psychiat & Neurol, Inst Personalized Psychiat & Neurol, Shared Core Facil, St Petersburg 192019, Russia.; Shnayder, NA (corresponding author), VF Voino Yasenetsky Krasnoyarsk State Med Univ, Shared Core Facil Mol & Cell Technol, Krasnoyarsk 660022, Russia.; Nasyrova, RF (corresponding author), Samara State Med Univ, Int Ctr Educ & Res Neuropsychiat, Samara 443016, Russia.
EM naschnaider@yandex.ru; grechkina.vv@mail.ru; vera.v.trefilova@yandex.ru;
   efremovilya102@gmail.com; shapo_jain@mail.ru; katya_n2001@mail.ru;
   stk99@yandex.ru; solovieva.irina@inbox.ru; liatepnadze@yandex.ru;
   polina.reznichenko.98@mail.ru; alzamil@mail.ru; profi.21@mail.ru;
   a.i.strelnik@samsmu.ru; nreginaf77@gmail.com
RI Petrova, Marina/L-5623-2014; Grechkina, Violetta/GYD-4476-2022;
   Al-Zamil, Mustafa/ABC-4735-2021; Народова, Екатерина/AAM-9051-2020;
   Strelnik, Anna/HLX-4607-2023; Trefilova, Vera/ADE-1550-2022; Shnayder,
   Natalia/M-7084-2014
OI Ekaterina, Narodova/0000-0002-6184-9206; Al-Zamil,
   Mustafa/0000-0002-3643-982X; Trefilova, Vera/0000-0002-4378-1308;
   Nasyrova, Regina/0000-0003-1874-9434; Strelnik,
   Anna/0000-0001-9589-5289; Shnayder, Natalia/0000-0002-2840-837X;
   Grechkina, Violetta/0000-0001-8279-4198
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NR 211
TC 6
Z9 6
U1 1
U2 10
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2227-9059
J9 BIOMEDICINES
JI Biomedicines
PD MAY 22
PY 2023
VL 11
IS 5
AR 1499
DI 10.3390/biomedicines11051499
PG 35
WC Biochemistry & Molecular Biology; Medicine, Research & Experimental;
   Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Research & Experimental Medicine;
   Pharmacology & Pharmacy
GA J7IL0
UT WOS:001011318500001
PM 37239168
OA gold
DA 2025-06-11
ER

PT J
AU Gao, WQ
   Xiao, CY
   Hu, J
   Chen, BX
   Wang, CY
   Cui, BP
   Deng, PY
   Yang, J
   Deng, ZF
AF Gao, Wenqi
   Xiao, Changyi
   Hu, Jun
   Chen, Biaoxin
   Wang, Chunyan
   Cui, Bangping
   Deng, Pengyi
   Yang, Jian
   Deng, Zhifang
TI Qing brick tea (QBT) aqueous extract protects monosodium
   glutamate-induced obese mice against metabolic syndrome and involves
   up-regulation Transcription Factor Nuclear Factor-Erythroid 2-Related
   Factor 2 (Nrf2) antioxidant pathway
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Article
DE Qing brick tea; Metabolic syndrome; Nrf2; Oxidative stress
ID CHOLESTEROL EDUCATION-PROGRAM; ENDOPLASMIC-RETICULUM STRESS; OXIDATIVE
   STRESS; INHIBITORY-ACTIVITY; ISOLATED FRACTIONS; HEART-DISEASE; WATER
   EXTRACT; DARK TEA; PREVALENCE; CELLS
AB Background: Qing brick tea (QBT), traditional and popular beverage for Chinese people, is an important post-fermentation dark tea. Our present study was performed to investigate the ameliorative effects of QBT aqueous extract on metabolic syndrome (Mets) in monosodium glutamate-induced obese mice and the potential mechanisms.
   Method: Monosodium glutamate-induced obese mice were used to evaluate the anti-Mets effects of QBT. Content levels of malonaldehyde (MDA), reactive oxygen species (ROS) and protein carbonylation, antioxidant enzyme activities of superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT), glutathione reductase (GR) in the skeletal muscle were assessed by commercial kits, respectively. Western blot and Q-PCR were used to detect the expressions of Transcription Factor Nuclear Factor-Erythroid 2-Related Factor 2 (Nrf2) signaling pathway and downstream antioxidant factors. In addition, activity of AKT signaling and expression of glucose transporter type 4 (GLUT4) in the skeletal muscle were investigated by western blot.
   Result: QBT treatment limited gain of body weight, waistline and LEE index, improved insulin resistance and glucose intolerance, reduced lipid level in MSG mice. Content levels of MDA, ROS and protein carbonylation in skeletal muscle of QBT group were significantly improved compared to those of MSG mice. The antioxidant enzyme activities of SOD, GPx, CAT, and GR were increased in skeletal muscle of MSG mice intervened with QBT. After 20-week QBT treatment, Nrf2 signaling pathway and downstream antioxidant factors were both increased in the skeletal muscle. In addition, QBT treatment improved insulin signaling by preferentially augmenting AKT signaling, as well as increased the protein expression of GLUT4 in the skeletal muscle.
   Conclusion: Our results showed that QBT intake was effective in protecting monosodium glutamate-induced obese mice against metabolic syndrome and involved in the Nrf2 signaling pathway in the skeletal muscle.
C1 [Gao, Wenqi; Xiao, Changyi; Hu, Jun; Chen, Biaoxin; Yang, Jian] China Three Gorges Univ, Dept Cent Expt Lab, Yichang 443003, Peoples R China.
   [Gao, Wenqi; Xiao, Changyi; Hu, Jun; Chen, Biaoxin; Yang, Jian] China Three Gorges Univ, Coll Clin Med Sci 1, Yichang Key Lab Ischem Cardiovasc & Cerebrovasc D, Yichang 443003, Peoples R China.
   [Gao, Wenqi; Xiao, Changyi; Hu, Jun; Chen, Biaoxin; Cui, Bangping; Deng, Pengyi; Yang, Jian; Deng, Zhifang] Yichang Cent Peoples Hosp, Yichang 443003, Peoples R China.
   [Deng, Zhifang] China Three Gorges Univ, Coll Clin Med Sci 1, Dept Pharm, Yichang 443000, Peoples R China.
   [Wang, Chunyan] Chang Sheng Chuan Hubei Qingzhuan Brick Tea Inst, Yichang 443002, Peoples R China.
   [Cui, Bangping; Deng, Pengyi] China Three Gorges Univ, Coll Clin Med Sci 1, Dept Nucl Med, Yichang 443000, Peoples R China.
C3 China Three Gorges University; China Three Gorges University; China
   Three Gorges University; China Three Gorges University
RP Yang, J (corresponding author), China Three Gorges Univ, Dept Cent Expt Lab, Yichang 443003, Peoples R China.; Yang, J (corresponding author), China Three Gorges Univ, Coll Clin Med Sci 1, Yichang Key Lab Ischem Cardiovasc & Cerebrovasc D, Yichang 443003, Peoples R China.; Yang, J; Deng, ZF (corresponding author), Yichang Cent Peoples Hosp, Yichang 443003, Peoples R China.; Deng, ZF (corresponding author), China Three Gorges Univ, Coll Clin Med Sci 1, Dept Pharm, Yichang 443000, Peoples R China.
EM yangjian@ctgu.edu.cn; dengzhifang@ctgu.edu.cn
RI deng, zhifang/GSE-0968-2022
FU National Natural Science Foundation of China [81470387]; Yichang Key
   Laboratory of ischemic cardiovascular and cerebrovascular disease
   translational medicine foundation [2017KXN09]
FX We gratefully acknowledge the National Natural Science Foundation of
   China (81470387) and Yichang Key Laboratory of ischemic cardiovascular
   and cerebrovascular disease translational medicine foundation
   (2017KXN09) for generous financial support for generous financial
   support.
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NR 34
TC 28
Z9 28
U1 0
U2 25
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD JUL
PY 2018
VL 103
BP 637
EP 644
DI 10.1016/j.biopha.2018.04.043
PG 8
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA GH3UW
UT WOS:000433328800077
PM 29679905
DA 2025-06-11
ER

PT J
AU DeBoer, MD
   Gurka, MJ
AF DeBoer, Mark D.
   Gurka, Matthew J.
TI Clinical utility of metabolic syndrome severity scores: considerations
   for practitioners
SO DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
LA English
DT Review
DE metabolic syndrome; insulin resistance; cardiovascular disease; type 2
   diabetes; risk prediction
ID CONFIRMATORY FACTOR-ANALYSIS; CORONARY-HEART-DISEASE; SYNDROME RISK
   SCORE; C-REACTIVE PROTEIN; CARDIOVASCULAR RISK; URIC-ACID;
   PHYSICAL-ACTIVITY; INSULIN-RESISTANCE; LIFE-STYLE; ATHEROSCLEROSIS RISK
AB The metabolic syndrome (MetS) is marked by abnormalities in central obesity, high blood pressure, high triglycerides, low high-density lipoprotein-cholesterol, and high fasting glucose and appears to be produced by underlying processes of inflammation, oxidative stress, and adipocyte dysfunction. MetS has traditionally been classified based on dichotomous criteria that deny that MetS-related risk likely exists as a spectrum. Continuous MetS scores provide a way to track MetS-related risk over time. We generated MetS severity scores that are sex-and race/ethnicity-specific, acknowledging that the way MetS is manifested may be different by sex and racial/ethnic subgroup. These scores are correlated with long-term risk for type 2 diabetes mellitus and cardiovascular disease. Clinical use of scores like these provide a potential opportunity to identify patients at highest risk, motivate patients toward lifestyle change, and follow treatment progress over time.
C1 [DeBoer, Mark D.] Univ Virginia, Sch Med, Dept Pediat, Div Pediat Endocrinol, 409 Lane Rd,Room 2017,POB 800386, Charlottesville, VA 22908 USA.
   [DeBoer, Mark D.; Gurka, Matthew J.] Univ Florida, Coll Med, Dept Hlth Outcomes & Policy, Gainesville, FL USA.
C3 University of Virginia; State University System of Florida; University
   of Florida
RP DeBoer, MD (corresponding author), Univ Virginia, Sch Med, Dept Pediat, Div Pediat Endocrinol, 409 Lane Rd,Room 2017,POB 800386, Charlottesville, VA 22908 USA.
EM deboer@virginia.edu
OI DeBoer, Mark/0000-0003-1462-591X
FU National Institutes of Health [1R01HL120960]
FX This work was supported by National Institutes of Health grant
   1R01HL120960 (MJG and MDD).
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NR 80
TC 75
Z9 83
U1 0
U2 16
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-7007
J9 DIABET METAB SYND OB
JI Diabetes Metab. Syndr. Obes.
PY 2017
VL 10
BP 65
EP 72
DI 10.2147/DMSO.S101624
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA EL6AD
UT WOS:000394701900001
PM 28255250
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Nishihira, J
   Sato-Ueshima, M
   Kitadate, K
   Wakame, K
   Fujii, H
AF Nishihira, Jun
   Sato-Ueshima, Maremi
   Kitadate, Kentaro
   Wakame, Koji
   Fujii, Hajime
TI Amelioration of abdominal obesity by low-molecular-weight polyphenol
   (Oligonol) from lychee
SO JOURNAL OF FUNCTIONAL FOODS
LA English
DT Article
DE Adipokine; Adiponectin; Insulin resistance; Metabolic syndrome; Obesity;
   Polyphenol
ID TUMOR-NECROSIS-FACTOR; GREEN TEA POLYPHENOL; OXIDATIVE STRESS;
   ADIPOSE-TISSUE; EXPRESSION; ADIPONECTIN; DISEASE; INFLAMMATION;
   RESISTANCE; ENDOCRINE
AB The effect of low-molecular-weight polyphenols extracted from lychee (Oligonol) on metabolic syndrome characterized by abdominal obesity was examined. We performed a clinical trial for Oligonol conducted by randomized double-blind, placebo-controlled study. Eighteen (male, 14; female, 4) adult volunteers with abdominal circumference over 85 cm were enrolled and divided into two groups, Oligonol and placebo groups. All subjects took two capsules of Oligonol (50 mg/capsule) or placebo twice a day for 10 weeks. Physical and haematological examinations as well as a CT scan of the abdomen were carried out, before (control) and 10 weeks after Oligonol intake. Clinical parameters of body weight, abdominal circumference and visceral fat volume were significantly decreased in the Oligonol group compared to the control. Insulin resistance was improved by Oligonol in conjunction with elevation of serum adiponectin. These results suggest that Oligonol ameliorates metabolic syndrome by reducing visceral fat obesity. (C) 2009 Published by Elsevier Ltd.
C1 [Nishihira, Jun; Sato-Ueshima, Maremi] Hokkaido Informat Univ, Dept Med Management & Informat, Ebetsu, Hokkaido 0694411, Japan.
   [Nishihira, Jun; Sato-Ueshima, Maremi] Sapporo Bio S, Knowledge Cluster, Sapporo, Hokkaido 0010021, Japan.
   [Kitadate, Kentaro; Wakame, Koji; Fujii, Hajime] Amino Up Chem Co Ltd, Sapporo, Hokkaido 0040839, Japan.
RP Nishihira, J (corresponding author), Hokkaido Informat Univ, Dept Med Management & Informat, Ebetsu, Hokkaido 0694411, Japan.
EM nishihira-jun@kpa.biglobe.ne.jp
FU Ministry of Education, Culture, Sports, Science, and Technology of
   Japan; National Institute of Biomedical Innovation (NIBIO)
FX We are grateful to Ms. Aiko Tanaka for preparation of this manuscript.
   This work was partially supported by Grants-in-Aid for Knowledge Cluster
   Sapporo Bio-S from the Ministry of Education, Culture, Sports, Science,
   and Technology of Japan (JN), and the Program for Promotion of
   Fundamental Studies in Health Science of the National Institute of
   Biomedical Innovation (NIBIO) (JN).
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NR 33
TC 25
Z9 29
U1 1
U2 21
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1756-4646
EI 2214-9414
J9 J FUNCT FOODS
JI J. Funct. Food.
PD OCT
PY 2009
VL 1
IS 4
BP 341
EP 348
DI 10.1016/j.jff.2009.09.002
PG 8
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA 684OV
UT WOS:000284560100003
DA 2025-06-11
ER

PT J
AU Réggami, Y
   Benkhaled, A
   Boudjelal, A
   Berredjem, H
   Amamra, A
   Benyettou, H
   Larabi, N
   Senator, A
   Siracusa, L
   Ruberto, G
AF Reggami, Yassine
   Benkhaled, Abderrahim
   Boudjelal, Amel
   Berredjem, Hajira
   Amamra, Amani
   Benyettou, Halima
   Larabi, Nadia
   Senator, Abderrahmane
   Siracusa, Laura
   Ruberto, Giuseppe
TI Artemisia herba-alba aqueous extract improves insulin sensitivity
   and hepatic steatosis in rodent model of fructose-induced metabolic
   syndrome
SO ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
LA English
DT Article
DE Artemisia herba-alba; Fructose; Metabolic syndrome; Rats
ID DENSITY-LIPOPROTEIN CHOLESTEROL; FATTY LIVER-DISEASE; OXIDATIVE STRESS;
   RESISTANCE; ACID; ASSO; ANTIOXIDANT; GLUTATHIONE; METFORMIN; PLASMA
AB Context: Fructose consumption is associated with the development of obesity and metabolic syndrome (MetS) in human and animal models. Objective: This study investigates the ability of an aqueous extract of Artemisia herba-alba Asso (AH) to ameliorate fructose-induced MetS in Male Wistar rats. Methods: AH extract at doses of 100, 200 and 400 mg/kg b.w./day was administered for six weeks to MetS animals. Results: Liquid fructose (10% w/v) intake did not vary total animal body weight, whereas, it produced moderate hyperglycemia associated with metabolic and histological alterations. Treating MetS rats with AH extract improved insulin sensitivity, alleviated atherogenic dyslipidaemia and decreased lipid deposition in their hepatic tissues. Additionally, AH extract was found to raise GSH level and antioxidant enzymes (GPx, GST and CAT) activities in rat livers homogenates. Conclusion: The results here reported demonstrated, for the first time, that A. herba-alba have therapeutic proprieties against fructose-induced MetS in rodent model.
C1 [Reggami, Yassine; Benkhaled, Abderrahim; Boudjelal, Amel; Benyettou, Halima; Larabi, Nadia] Mohamed Boudiaf Msila Univ, Fac Sci, Dept Microbiol & Biochem, POB 166, Msila 28000, Algeria.
   [Reggami, Yassine; Berredjem, Hajira; Amamra, Amani] Badji Mokhtar Annaba Univ, Fac Sci, Dept Biochem, Lab Biochem & Appl Microbiol, Annaba, Algeria.
   [Senator, Abderrahmane] Ferhat Abbas Setif Univ, Fac Nat & Life Sci, Lab Appl Biochem, Setif, Algeria.
   [Siracusa, Laura; Ruberto, Giuseppe] ICB CNR, Catania, Italy.
C3 Universite Badji Mokhtar - Annaba; Consiglio Nazionale delle Ricerche
   (CNR); Istituto di Chimica Biomolecolare (ICB-CNR)
RP Réggami, Y (corresponding author), Mohamed Boudiaf Msila Univ, Fac Sci, Dept Microbiol & Biochem, POB 166, Msila 28000, Algeria.
EM yassine.reggami@univ-msila.dz
RI BERREDJEM, Hajira/AAF-7318-2020; Benkhaled, Abderrahim/AAK-1283-2021;
   Reggami, Yassine/G-3660-2016
OI Reggami, Yassine/0000-0003-3780-2333; BERREDJEM,
   Hajira/0000-0001-9690-778X; Abderrahmane, Senator/0000-0002-3472-0538;
   Abderrahim, Benkhaled/0000-0003-4635-1626
FU Algerian Ministry of Higher Education and Scientific Research, via
   Mohamed Boudiaf-M'sila University (M'sila, Algeria) [CNEPRU/F
   05620110004]; Istituto di Chimica Biomolecolare del Consiglio Nazionale
   delle Ricerche (ICB-CNRRome, Italy)
FX This work was supported by Algerian Ministry of Higher Education and
   Scientific Research, via Mohamed Boudiaf-M'sila University (M'sila,
   Algeria) [grant number: CNEPRU/F 05620110004]; and the Istituto di
   Chimica Biomolecolare del Consiglio Nazionale delle Ricerche
   (ICB-CNRRome, Italy).
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NR 71
TC 13
Z9 15
U1 1
U2 11
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1381-3455
EI 1744-4160
J9 ARCH PHYSIOL BIOCHEM
JI Arch. Physiol. Biochem.
PD NOV 2
PY 2021
VL 127
IS 6
BP 541
EP 550
DI 10.1080/13813455.2019.1659825
EA AUG 2019
PG 10
WC Biochemistry & Molecular Biology; Biophysics; Endocrinology &
   Metabolism; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Endocrinology &
   Metabolism; Physiology
GA WO7NO
UT WOS:000484158400001
PM 31464524
DA 2025-06-11
ER

PT J
AU Huang, CH
   Su, SL
   Hsieh, MC
   Cheng, WL
   Chang, CC
   Wu, HL
   Kuo, CL
   Lin, TT
   Liu, CS
AF Huang, Ching-Hui
   Su, Shih-Li
   Hsieh, Ming-Chia
   Cheng, Wen-Ling
   Chang, Chia-Chu
   Wu, Hsi-Lin
   Kuo, Chen-Ling
   Lin, Ta-Tsung
   Liu, Chin-San
TI Depleted Leukocyte Mitochondrial DNA Copy Number in Metabolic Syndrome
SO JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
LA English
DT Article
DE Hypertension; Hypertriglyceridemia; Metabolic syndrome; Mitochondrial
   DNA
ID CORONARY-HEART-DISEASE; TRANSCRIPTION FACTOR-A; PERIPHERAL-BLOOD;
   LIPOPROTEIN CHOLESTEROL; ESSENTIAL-HYPERTENSION; OXIDATIVE STRESS;
   OVEREXPRESSION; IMPAIRMENT; BIOGENESIS; FAILURE
AB Aims: Metabolic syndrome (MetS) is characterized by a group of defects of metabolic origin which are possibly involved in mitochondrial DNA (mtDNA) alteration of mtDNA content [Lee et al. Exp Biol Med, 2007; 232(5): 592-606]. The present study was undertaken to ascertain whether alteration of leukocyte mtDNA copy number is related to MetS.
   Methods: Eighty non-MetS subjects and 50 subjects with MetS were recruited. The mtDNA copy number of leukocytes from each group of subjects was measured using quantitative polymerase chain reaction.
   Results: The mtDNA copy number of leukocytes in subjects with MetS was significantly lower than that of non-MetS subjects. Depleted mtDNA copy number is correlated with lower plasma HDL, higher triglyceride, higher HOMA-IR and hypertension, and is even more sensitive to MetS criteria.
   Conclusions: Depleted leukocyte mtDNA copy number is related to the severity of MetS. Alteration of mtDNA copy number in leukocytes is proposed as a MetS biomarker involved in the bioenergetic change of mitochondria.
C1 [Liu, Chin-San] Changhua Christian Hosp, Dept Neurol, Vasc & Genom Res Ctr, Changhua 500, Taiwan.
   [Huang, Ching-Hui] Changhua Christian Hosp, Dept Internal Med, Div Cardiol, Changhua 500, Taiwan.
   [Su, Shih-Li; Hsieh, Ming-Chia] Changhua Christian Hosp, Dept Internal Med, Div Endocrinol & Metab, Changhua 500, Taiwan.
   [Chang, Chia-Chu] Changhua Christian Hosp, Dept Internal Med, Div Nephrol, Changhua 500, Taiwan.
   [Liu, Chin-San] China Med Univ, Grad Inst Integrated Med, Taichung, Taiwan.
C3 Changhua Christian Hospital; Changhua Christian Hospital; Changhua
   Christian Hospital; Changhua Christian Hospital; China Medical
   University Taiwan
RP Liu, CS (corresponding author), Changhua Christian Hosp, Dept Neurol, Vasc & Genom Res Ctr, 135 Nanhsiao St, Changhua 500, Taiwan.
EM 48111@gmail.com
RI Chen, yafang/GVS-0304-2022; é™³, ç‘žå‚‘/HCH-5712-2022
FU Changhua Christian Hospital
FX We would like to thank Changhua Christian Hospital for supporting the
   research foundation.
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NR 31
TC 45
Z9 50
U1 0
U2 7
PU JAPAN ATHEROSCLEROSIS SOC
PI TOKYO
PA NICHINAI-KAIKAN B1, 3-28-8 HONGO BUNKYO-KU, TOKYO, 113-0033, JAPAN
SN 1340-3478
EI 1880-3873
J9 J ATHEROSCLER THROMB
JI J. Atheroscler. Thromb.
PY 2011
VL 18
IS 10
BP 867
EP 873
DI 10.5551/jat.8698
PG 7
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 856VS
UT WOS:000297673000004
PM 21844659
OA hybrid
DA 2025-06-11
ER

PT J
AU Eriksson, JW
AF Eriksson, Jan W.
TI Metabolic stress in insulin's target cells leads to ROS accumulation - A
   hypothetical common pathway causing insulin resistance
SO FEBS LETTERS
LA English
DT Review
DE stress; reactive oxygen species; oxidative stress; insulin resistance;
   metabolic syndrome; type 2 diabetes; adipocyte; glucotoxicity;
   lipotoxicity
ID TYPE-2 DIABETES PATIENTS; AUTONOMIC NERVOUS-SYSTEM;
   HEART-RATE-VARIABILITY; IN-VITRO REVERSAL; OXIDATIVE STRESS;
   FATTY-ACIDS; PHOSPHATIDYLINOSITOL 3-KINASE; 1ST-DEGREE RELATIVES;
   GLUCOSE-TRANSPORT; SKELETAL-MUSCLE
AB The metabolic syndrome is a cluster of cardiovascular risk factors, and visceral adiposity is a central component that is also strongly associated with insulin resistance. Both visceral obesity and insulin resistance are important risk factors for the development of type 2 diabetes. It is likely that adipose tissue, particularly in the intra-abdominal depot, is part of a complex interplay involving several tissues and that dysregulated hormonal, metabolic and neural signalling within and between organs can trigger development of metabolic disease. One attractive hypothesis is that many factors leading to insulin resistance are mediated via the generation of abnormal amounts of reactive oxygen species (ROS). There is much evidence supporting that detrimental effects of glucose, fatty acids, hormones and cytokines leading to insulin resistance can be exerted via such a common pathway. This review paper mainly focuses on metabolic and other 'stress' factors that affect insulin's target cells, in particular adipocytes, and it will highlight oxidative stress as a potential unifying mechanism by which these stress factors promote insulin resistance and the development and progression of type 2 diabetes. (c) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
C1 Sahlgrens Univ Hosp, Inst Med, Lundberg Lab Diabet Res, SE-41345 Gothenburg, Sweden.
   Sweden & AstraZeneca R&D, Molndal, Sweden.
C3 Sahlgrenska University Hospital; AstraZeneca
RP Eriksson, JW (corresponding author), Sahlgrens Univ Hosp, Inst Med, Lundberg Lab Diabet Res, SE-41345 Gothenburg, Sweden.
EM jan.eriksson@medic.gu.se
RI Eriksson, Jan/AAB-5820-2021
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NR 63
TC 139
Z9 163
U1 0
U2 12
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0014-5793
EI 1873-3468
J9 FEBS LETT
JI FEBS Lett.
PD JUL 31
PY 2007
VL 581
IS 19
SI SI
BP 3734
EP 3742
DI 10.1016/j.febslet.2007.06.044
PG 9
WC Biochemistry & Molecular Biology; Biophysics; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Cell Biology
GA 200TZ
UT WOS:000248787000021
PM 17628546
DA 2025-06-11
ER

PT J
AU Katsiki, N
   Stoian, AP
   Steiropoulos, P
   Papanas, N
   Suceveanu, AI
   Mikhailidis, DP
AF Katsiki, Niki
   Stoian, Anca Pantea
   Steiropoulos, Paschalis
   Papanas, Nikolaos
   Suceveanu, Andra-Iulia
   Mikhailidis, Dimitri P.
TI Metabolic Syndrome and Abnormal Peri-Organ or Intra-Organ Fat (APIFat)
   Deposition in Chronic Obstructive Pulmonary Disease: An Overview
SO METABOLITES
LA English
DT Review
DE chronic obstructive pulmonary disease; metabolic syndrome; metabolic
   markers; non-alcoholic fatty liver disease; epicardial fat;
   non-alcoholic fatty pancreas disease; intramuscular fat; abnormal
   peri-organ fat; abnormal intra-organ fat
ID EPICARDIAL ADIPOSE-TISSUE; TYPE-2 DIABETES-MELLITUS; LIVER-DISEASE;
   SLEEP-APNEA; SKELETAL-MUSCLE; SYSTEMIC INFLAMMATION; OXIDATIVE STRESS;
   SUBCLINICAL ATHEROSCLEROSIS; CARDIOVASCULAR-DISEASE;
   MYOCARDIAL-INFARCTION
AB Chronic obstructive pulmonary disease (COPD) is a common disorder with an increasing prevalence, characterised by persistent respiratory symptoms and airflow limitation. Systemic inflammation is involved in the pathogenesis of COPD and can also predispose to metabolic disorders (e.g., metabolic syndrome (MetS) and non-alcoholic fatty liver disease (NAFLD)). Such comorbidities can negatively affect COPD outcomes, cardiovascular risk, and quality of life. Apart from NAFLD, abnormal peri-organ or intra-organ fat (APIFat) could be considered as markers for cardiometabolic diseases and even for COPD. The present narrative review considers the associations of COPD with MetS, NAFLD, and other APIFat, including epicardial, perirenal, peripancreatic, and intramuscular adipose tissue. Further research is needed to define these relationships and identify any potential clinical implications.
C1 [Katsiki, Niki] Ahepa Univ Hosp, Div Endocrinol & Metab, Diabet Ctr, Dept Internal Med 1, 1st Stilponos Kyriakidi, Thessaloniki 54621, Greece.
   [Stoian, Anca Pantea] Carol Davila Univ Med, Diabet Nutr & Metab Dis Dept, 8 Eroii Sanitari, Bucharest 050474, Romania.
   [Steiropoulos, Paschalis] Democritus Univ Thrace, Dept Pneumonol, Alexandroupolis 68100, Greece.
   [Papanas, Nikolaos] Democritus Univ Thrace, Med Sch, Dept Internal Med 2, Diabet Ctr, Alexandroupolis 68100, Greece.
   [Suceveanu, Andra-Iulia] Ovidius Univ, Fac Med, Constanta 900470, Romania.
   [Mikhailidis, Dimitri P.] Univ Coll London UCL, Dept Clin Biochem, Med Sch, Royal Free Hosp campus, London NW3 2QG, England.
C3 Aristotle University of Thessaloniki; Ahepa University Hospital; Carol
   Davila University of Medicine & Pharmacy; Democritus University of
   Thrace; Democritus University of Thrace; Ovidius University; University
   of London; University College London; Royal Free London NHS Foundation
   Trust
RP Stoian, AP (corresponding author), Carol Davila Univ Med, Diabet Nutr & Metab Dis Dept, 8 Eroii Sanitari, Bucharest 050474, Romania.; Papanas, N (corresponding author), Democritus Univ Thrace, Med Sch, Dept Internal Med 2, Diabet Ctr, Alexandroupolis 68100, Greece.
EM nikikatsiki@hotmail.com; ancastoian@yahoo.com; pstirop@med.duth.gr;
   papanasnikos@yahoo.gr; andrasuceveanu@yahoo.com; mikhailidis@aol.com
RI Mikhailidis, Dimitri/A-1869-2013; Steiropoulos, Paschalis/AAH-6905-2021;
   Suceveanu, Andra/M-8100-2019; Pantea Stoian, Anca/H-5799-2017; KATSIKI,
   NIKI/ADE-7999-2022
OI Pantea Stoian, Anca/0000-0003-0555-526X; KATSIKI,
   NIKI/0000-0003-0894-2644
FU Angelini; Astra Zeneca; Mylan; Novo Nordisk; Sanofi; Servier;
   AstraZeneca; Boehringer Ingelheim GlaxoSmithKline; Chiesi; Pfizer;
   National Diabetes Commission; Abbott; Eli Lilly; MSD; Takeda; Libytec;
   Elpen; Bausch Health; Boehringer Ingelheim; Ministry of Health, Romania
FX N.K. has given talks, attended conferences, and participated in trials
   sponsored by Angelini, Astra Zeneca, Bausch Health, Boehringer
   Ingelheim, Elpen, Mylan, Novo Nordisk, Sanofi, and Servier. P.S. has
   given talks, attended conferences and participated in advisory boards
   and trials sponsored by AstraZeneca, Boehringer Ingelheim
   GlaxoSmithKline, Chiesi, Elpen, Menarini, Novartis, and Pfizer. A.P.S.
   has given talks, attended conferences, and participated in advisory
   boards, and clinical trials sponsored by various pharmaceutical
   companies and she is currently Vice-President, National Diabetes
   Commission, Ministry of Health, Romania. N.P. has been an advisory board
   member of TrigoCare International, Abbott, AstraZeneca, Elpen, MSD,
   Novartis, Novo Nordisk, Sanofi-Aventis, and Takeda; has participated in
   sponsored studies by Eli Lilly, MSD, Novo Nordisk, Novartis, and
   Sanofi-Aventis; received honoraria as a speaker for AstraZeneca,
   Boehringer Ingelheim, Eli Lilly, Elpen, Galenica, MSD, Mylan, Novartis,
   Novo Nordisk, Pfizer, Sanofi-Aventis, Takeda, and Vianex; and attended
   conferences sponsored by TrigoCare International, AstraZeneca,
   Boehringer Ingelheim, Eli Lilly, Novartis, Novo Nordisk, Pfizer, and
   Sanofi-Aventis. D.P.M has given talks and attended conferences sponsored
   by Amgen, Novo Nordisk, and Libytec.
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NR 145
TC 12
Z9 12
U1 1
U2 22
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2218-1989
J9 METABOLITES
JI Metabolites
PD NOV
PY 2020
VL 10
IS 11
AR 465
DI 10.3390/metabo10110465
PG 16
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA OX8WE
UT WOS:000593837300001
PM 33203192
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Taskinen, MR
   Packard, CJ
   Borén, J
AF Taskinen, Marja-Riitta
   Packard, Chris J.
   Boren, Jan
TI Dietary Fructose and the Metabolic Syndrome
SO NUTRIENTS
LA English
DT Article
DE fructose; metabolic syndrome; hypertriglyceridemia; metabolism
ID FATTY LIVER-DISEASE; SERUM URIC-ACID; DE-NOVO LIPOGENESIS; SWEETENED
   BEVERAGES; INSULIN SENSITIVITY; HEPATIC STEATOSIS;
   CARDIOVASCULAR-DISEASE; CARDIOMETABOLIC HEALTH; INTRAHEPATIC LIPIDS;
   OXIDATIVE STRESS
AB Consumption of fructose, the sweetest of all naturally occurring carbohydrates, has increased dramatically in the last 40 years and is today commonly used commercially in soft drinks, juice, and baked goods. These products comprise a large proportion of the modern diet, in particular in children, adolescents, and young adults. A large body of evidence associate consumption of fructose and other sugar-sweetened beverages with insulin resistance, intrahepatic lipid accumulation, and hypertriglyceridemia. In the long term, these risk factors may contribute to the development of type 2 diabetes and cardiovascular diseases. Fructose is absorbed in the small intestine and metabolized in the liver where it stimulates fructolysis, glycolysis, lipogenesis, and glucose production. This may result in hypertriglyceridemia and fatty liver. Therefore, understanding the mechanisms underlying intestinal and hepatic fructose metabolism is important. Here we review recent evidence linking excessive fructose consumption to health risk markers and development of components of the Metabolic Syndrome.
C1 [Taskinen, Marja-Riitta] Univ Helsinki, Res Program Clin & Mol Med Unit, Diabet & Obes, Helsinki 00029, Finland.
   [Packard, Chris J.] Univ Glasgow, Inst Cardiovasc & Med Sci, Glasgow G12 8QQ, Lanark, Scotland.
   [Boren, Jan] Univ Gothenburg, Dept Mol & Clin Med, S-41345 Gothenburg, Sweden.
   [Boren, Jan] Sahlgrens Univ Hosp, S-41345 Gothenburg, Sweden.
C3 University of Helsinki; University of Glasgow; University of Gothenburg;
   Sahlgrenska University Hospital
RP Borén, J (corresponding author), Univ Gothenburg, Dept Mol & Clin Med, S-41345 Gothenburg, Sweden.; Borén, J (corresponding author), Sahlgrens Univ Hosp, S-41345 Gothenburg, Sweden.
EM jan.boren@wlab.gu.se
RI Taskinen, Marja-Riitta/AAN-5432-2020
OI Taskinen, Marja-Riitta/0000-0002-6229-3588; Boren,
   Jan/0000-0003-0786-8091
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NR 148
TC 197
Z9 207
U1 11
U2 101
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD SEP
PY 2019
VL 11
IS 9
AR 1987
DI 10.3390/nu11091987
PG 16
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA JA6PP
UT WOS:000487964600070
PM 31443567
OA Green Accepted, Green Published, gold
HC Y
HP N
DA 2025-06-11
ER

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AU Santos, AE
   Araújo, LF
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   Giatti, L
AF Santos, Aline E.
   Araujo, Larissa F.
   Griep, Rosane H.
   Castro Moreno, Claudia R.
   Chor, Dora
   Barreto, Sandhi M.
   Giatti, Luana
TI Shift work, job strain, and metabolic syndrome: Cross-sectional analysis
   of ELSA-Brasil
SO AMERICAN JOURNAL OF INDUSTRIAL MEDICINE
LA English
DT Article
DE job strain; metabolic syndrome; occupational health; psychosocial
   factor; shift work
ID HEART-DISEASE; RISK-FACTORS; STRESS; HEALTH; COHORT; SLEEP; AGE
AB Background: Shift work and psychosocial stressors may contribute to higher metabolic syndrome (MetS) incidence. Few studies investigated whether the presence of both factors simultaneously has a synergic effect on risk of MetS.
   Methods: This cross-sectional analysis used baseline data (2008-2010) for 10960 current workers from ELSA-Brasil. Multiple logistic regression was used to estimate independent associations between shift work and job strain and MetS. An interaction between these factors was tested by including a multiplicative term in the final model.
   Results: Exposure to three-shifts a week (that is, three 12 h shifts of work followed by 36 h of rest) and high job-strain were independently associated with greater risk of MetS. We found no indication (P > 0.05) of interaction between working in shifts and job strain on MetS.
   Conclusions: Efforts to reduce job strain and shift work should be considered as part of a primary prevention strategy to reduce the risk of MetS.
C1 [Santos, Aline E.; Araujo, Larissa F.; Barreto, Sandhi M.; Giatti, Luana] Univ Fed Minas Gerais, Res Grp Epidemiol Chron & Occupat Dis GERMINAL, Fac Med, Belo Horizonte, MG, Brazil.
   [Araujo, Larissa F.] Univ Fed Ceara, Fac Med, Fortaleza, Ceara, Brazil.
   [Griep, Rosane H.] Fundacao Oswaldo Cruz, Lab Hlth & Environm Educ, Rio De Janeiro, Brazil.
   [Griep, Rosane H.; Chor, Dora] Fundacao Oswaldo Cruz, Natl Sch Publ Hlth, Rio De Janeiro, Brazil.
   [Castro Moreno, Claudia R.] Univ Sao Paulo, Dept Hlth Life Cycles & Soc, Sch Publ Hlth, Sao Paulo, Brazil.
   [Castro Moreno, Claudia R.] Univ Stockholm, Stress Res Inst, Stockholm, Sweden.
C3 Universidade Federal de Minas Gerais; Universidade Federal do Ceara;
   Fundacao Oswaldo Cruz; Fundacao Oswaldo Cruz; Universidade de Sao Paulo;
   Stockholm University
RP Giatti, L (corresponding author), Univ Fed Minas Gerais, Res Grp Epidemiol Chron & Occupat Dis GERMINAL, Dept Prevent & Social Med, Fac Med, BR-30130100 Belo Horizonte, MG, Brazil.
EM luana.giatti@gmail.com
RI Griep, Rosane/ABB-4509-2020; Barreto, Sandhi/D-2855-2014; Griep, Rosane
   Harter/E-3763-2013; Moreno, Claudia Roberta/I-3298-2012
OI Barreto, Sandhi/0000-0001-7383-7811; Griep, Rosane
   Harter/0000-0002-6250-2036; Araujo, Larissa F./0000-0001-6695-0365;
   Moreno, Claudia Roberta/0000-0003-1839-9673
FU Brazilian Ministry of Health (Department of Science and Technology);
   Brazilian Ministry of Science and Technology (the Brazilian Innovation
   Agency-FINEP and National Research Council-CNPq) [01 06 0010.00 RS, 01
   06 0212.00BA, 01 06 0300.00 ES, 01 06 0278.00MG, 01 06 0115.00SP, 01 06
   0071.00 RJ]; CNPq [300159/99-4, 303251/2013-1, 303371/2014-5,
   304840/2014-9, 150248/2015-6]; Foundation for Research Support of the
   State of Rio de Janeiro-FAPERJ [E26/201220/2014]; Foundation for
   Research Support of the State of Sao Paulo-FAPESP [2014/011514-0]
FX Brazilian Ministry of Health (Department of Science and Technology) and
   the Brazilian Ministry of Science and Technology (the Brazilian
   Innovation Agency-FINEP and National Research Council-CNPq), Grant
   numbers: 01 06 0010.00 RS, 01 06 0212.00BA, 01 06 0300.00 ES, 01 06
   0278.00MG, 01 06 0115.00SP, 01 06 0071.00 RJ; CNPq, Grant numbers:
   300159/99-4, 303251/2013-1, 303371/2014-5, 304840/2014-9, 150248/2015-6;
   Foundation for Research Support of the State of Rio de Janeiro-FAPERJ,
   Grant number: E26/201220/2014; Foundation for Research Support of the
   State of Sao Paulo-FAPESP, Grant number: 2014/011514-0
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NR 45
TC 13
Z9 14
U1 0
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0271-3586
EI 1097-0274
J9 AM J IND MED
JI Am. J. Ind. Med.
PD NOV
PY 2018
VL 61
IS 11
BP 911
EP 918
DI 10.1002/ajim.22910
PG 8
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA GW5MD
UT WOS:000446978400005
PM 30255944
DA 2025-06-11
ER

PT J
AU Pandrc, MS
   Ristic, A
   Kostovski, V
   Stankovic, M
   Antic, V
   Milin-Lazovic, J
   Ciric, J
AF Pandrc, Milena S.
   Ristic, Andelka
   Kostovski, Vanja
   Stankovic, Marko
   Antic, Vladimir
   Milin-Lazovic, Jelena
   Ciric, Jasmina
TI THE EFFECT OF EARLY SUBSTITUTION OF SUBCLINICAL HYPOTHYROIDISM ON
   BIOCHEMICAL BLOOD PARAMETERS AND THE QUALITY OF LIFE
SO JOURNAL OF MEDICAL BIOCHEMISTRY
LA English
DT Article
DE subclinical hypothyroidism; biochemical parameters; quality of life;
   early T4 substitution
ID THYROID-FUNCTION; DOUBLE-BLIND; INSULIN-RESISTANCE;
   CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; LIPID PROFILE; RISK-FACTOR;
   HORMONES; TSH; INFLAMMATION
AB Background: Subclinical hypothyroidism (SCH) is defined as high TSH and normal thyroxine. Data on the effects of early substitution by levothyroxine on psychophysical health in SCH are still not consistent enough to support its introduction.
   Methods: Clinical parameters, biochemical data and quality of life (Short Form 36 questionnaire) were measured before the intervention and 3 months after the euthyroid state had been achieved in SCH patients.
   Results: Significant reduction in body weight (p = 0.030), systolic and diastolic blood pressure (p = 0.024, p = 0.019), homocysteine (p< 0.001), leukocytes and neutrophils (p = 0.011, p = 0.001), INR (p = 0.049), K levels (p = 0.040, p= 0.013), HbA1c (p= 0.001), fasting insulin (p< 0.001) and insulin resistance measured by HOMA index (p< 0.001), lipid parameters (total cholesterol (p< 0.001), LDL-cholesterol (p< 0.001), triglycerides (p = 0.007), apoB (p = 0.022), Lp(a) (p< 0.001), LDL/HDL (p = 0.008), LAP (p = 0.04) and apoB/apoA1 ratios (p< 0.023)), TSH (p< 0.001) and tAbs p< 0.001) was recorded. Frequency of fatty liver (20% to 2.9%, p = 0.016), hyperlipidemia (85% to 65.7%, p = 0.001) and metabolic syndrome (34.3% to 2.9%, p = 0.070) significantly decreased. A statistically significant positive association was found between the average dose of levothyroxine and changes in physical functioning (r= 0.391, p = 0.020), vitality (r= 0.393, p = 0.020), mental health (r= 0.374, p = 0.027) and overall dimensions of mental health (r= 0.376, p = 0.026). With increasing doses of levothyroxine, the previously listed scores of SF 36 grew (r= 0.296, p = 0.084).
   Conclusions: Early substitution of SCH improved the many clinical and biochemical parameters related to cardiovascular risk. Quality of life was also improved, and correlated only with thyroxine doses suggesting an indirect relationship between the degree of hypothyroidism and quality of life.
C1 [Pandrc, Milena S.] Mil Med Acad, Dept Internal Med, Crnotravska 17, Belgrade 11000, Serbia.
   [Ciric, Jasmina] Univ Belgrade, Sch Med, Clin Ctr Serbia, Clin Endocrinol Diabet & Metab Dis, Belgrade, Serbia.
   [Ristic, Andelka] Mil Med Acad, Dept Urgent Internal Med, Belgrade, Serbia.
   [Kostovski, Vanja] Mil Med Acad, Clin Thorac Surg, Belgrade, Serbia.
   [Stankovic, Marko] Primary Med Ctr Dr Simo Milosevic, Belgrade, Serbia.
   [Antic, Vladimir] Mil Med Acad, Dept Radiol, Belgrade, Serbia.
   [Milin-Lazovic, Jelena] Clin Ctr Serbia, Inst Med Stat & Informat, Belgrade, Serbia.
C3 Clinical Centre of Serbia; University of Belgrade; University of
   Belgrade; Clinical Centre of Serbia
RP Pandrc, MS (corresponding author), Mil Med Acad, Dept Internal Med, Crnotravska 17, Belgrade 11000, Serbia.
EM pandrcmilena@yahoo.com
OI Milin Lazovic, Jelena/0000-0002-4655-2383
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NR 53
TC 16
Z9 18
U1 1
U2 6
PU SOC MEDICAL BIOCHEMISTS SERBIA
PI BELGRADE
PA VOJISLAVA ILICA 94B, I SPRAT, STAN 7, BELGRADE, VOZDOVAC, SERBIA
SN 1452-8258
EI 1452-8266
J9 J MED BIOCHEM
JI J. Med. Biochem.
PD APR
PY 2017
VL 36
IS 2
BP 127
EP 136
DI 10.1515/jomb-2017-0007
PG 10
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA ES9UO
UT WOS:000399907200004
PM 28680356
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Morelli, V
   Bedney, DL
   Dadush, A
AF Morelli, Vincent
   Bedney, Daniel L.
   Dadush, Arie (Eric)
TI Exercise and Sports Medicine Issues in Underserved Populations
SO PRIMARY CARE
LA English
DT Article
DE Exercise; Underserved; Sports medicine; Socioeconomic status
ID ADOLESCENT PHYSICAL-ACTIVITY; DENSITY-LIPOPROTEIN CHOLESTEROL; CHILDHOOD
   AEROBIC FITNESS; BREAST-CANCER; EARLY MENARCHE; SOCIOECONOMIC-STATUS;
   COLORECTAL-CANCER; METABOLIC SYNDROME; BRAIN-DEVELOPMENT; MAJOR
   DEPRESSION
AB Primary care providers can make a strong argument for exercise promotion in underserved communities. The benefits are vitally important in adolescent physical, cognitive, and psychological development as well as in adult disease prevention and treatment. In counseling such patients, we should take into account a patient's readiness for change and the barriers to exercise.
C1 [Morelli, Vincent; Bedney, Daniel L.; Dadush, Arie (Eric)] Meharry Med Coll, Dept Family & Community Med, 1005 Dr DB Todd Blvd, Nashville, TN 37208 USA.
C3 Meharry Medical College
RP Morelli, V (corresponding author), Meharry Med Coll, Dept Family & Community Med, 1005 Dr DB Todd Blvd, Nashville, TN 37208 USA.
EM vmorelli@mmc.edu
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NR 123
TC 1
Z9 1
U1 0
U2 9
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0095-4543
EI 1558-299X
J9 PRIMARY CARE
JI Primary Care
PD MAR
PY 2017
VL 44
IS 1
BP 141
EP +
DI 10.1016/j.pop.2016.09.015
PG 15
WC Primary Health Care; Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA EM5OX
UT WOS:000395362600014
PM 28164813
DA 2025-06-11
ER

PT J
AU Andonian, BJ
   Ross, LM
   Sudnick, AM
   Johnson, JL
   Pieper, CF
   Belski, KB
   Counts, JD
   King, AP
   Wallis, JT
   Bennett, WC
   Gillespie, JC
   Moertl, KM
   Richard, D
   Huebner, JL
   Connelly, MA
   Siegler, IC
   Kraus, WE
   Bales, CW
   Starr, KNP
   Huffman, KM
AF Andonian, Brian J.
   Ross, Leanna M.
   Sudnick, Alyssa M.
   Johnson, Johanna L.
   Pieper, Carl F.
   Belski, Kelsey B.
   Counts, Julie D.
   King, Alyssa P.
   Wallis, Jessica T.
   Bennett, William C.
   Gillespie, Jillian C.
   Moertl, Kaileigh M.
   Richard, Dylan
   Huebner, Janet L.
   Connelly, Margery A.
   Siegler, Ilene C.
   Kraus, William E.
   Bales, Connie W.
   Starr, Kathryn N. Porter
   Huffman, Kim M.
TI Effect of Remotely Supervised Weight Loss and Exercise Training Versus
   Lifestyle Counseling on Cardiovascular Risk and Clinical Outcomes in
   Older Adults With Rheumatoid Arthritis: A Randomized Controlled Trial
SO ACR OPEN RHEUMATOLOGY
LA English
DT Article
ID CAUSE-SPECIFIC MORTALITY; REDUCTION INTERVENTION; RESISTANCE EXERCISE;
   METABOLIC SYNDROME; PHYSICAL-ACTIVITY; DISEASE; BLOOD; CHOLESTEROL
AB Objective. To compare a remotely supervised weight loss and exercise intervention to lifestyle counseling for effects on cardiovascular disease risk, disease activity, and patient-reported outcomes in older patients with rheumatoid arthritis (RA) and overweight/obesity.Methods. Twenty older (60-80 years), previously sedentary participants with seropositive RA and overweight/obesity were randomized to 16 weeks of either Supervised Weight loss and Exercise Training (SWET) or Counseling Health As Treatment (CHAT). The SWET group completed aerobic training (150 minutes/week moderate-to-vigorous intensity), resistance training (two days/week), and a hypocaloric diet (7% weight loss goal). The CHAT control group completed two lifestyle counseling sessions followed by monthly check-ins. The primary outcome was a composite metabolic syndrome z-score (MSSc) derived from fasting glucose, triglycerides, high density lipoprotein-cholesterol, minimal waist circumference, and mean arterial pressure. Secondary outcomes included RA disease activity and patient-reported outcomes.Results. Both groups improved MSSc (absolute change -1.67 +/- 0.64 in SWET; -1.34 +/- 1.30 in CHAT; P < 0.01 for both groups) with no between-group difference. Compared with CHAT, SWET significantly improved body weight, fat mass, Disease Activity Score-28 C-reactive protein, and patient-reported physical health, physical function, mental health, and fatigue (P < 0.04 for all between-group comparisons). Based on canonical correlations for fat mass, cardiorespiratory fitness, and leg strength, component-specific effects were strongest for (1) weight loss improving MSSc, physical health, and mental health; (2) aerobic training improving physical function and fatigue; and (3) resistance training improving Disease Activity Score-28 C-reactive protein.Conclusion. In older patients with RA and overweight/obesity, 16 weeks of remotely supervised weight loss, aerobic training, and resistance training improve cardiometabolic health, patient-reported outcomes, and disease activity. Less intensive lifestyle counseling similarly improves cardiovascular disease risk profiles, suggesting an important role for integrative interventions in the routine clinical care of this at-risk RA population.
C1 [Andonian, Brian J.; Pieper, Carl F.; Siegler, Ilene C.; Huffman, Kim M.] Duke Univ, Sch Med, Duke Mol Physiol Inst, Durham, NC 27708 USA.
   [Ross, Leanna M.; Sudnick, Alyssa M.; Johnson, Johanna L.; Belski, Kelsey B.; Counts, Julie D.; Bennett, William C.; Gillespie, Jillian C.; Moertl, Kaileigh M.; Richard, Dylan; Huebner, Janet L.; Kraus, William E.] Duke Univ, Sch Med, Durham, NC USA.
   [Ross, Leanna M.; Sudnick, Alyssa M.; Johnson, Johanna L.; Belski, Kelsey B.; Counts, Julie D.; Bennett, William C.; Gillespie, Jillian C.; Moertl, Kaileigh M.; Richard, Dylan; Huebner, Janet L.; Kraus, William E.; Starr, Kathryn N. Porter] Durham VA Med Ctr, Durham, NC USA.
   [King, Alyssa P.; Wallis, Jessica T.; Connelly, Margery A.; Bales, Connie W.] Labcorp, Morrisville, NC USA.
C3 Duke University; Duke University; US Department of Veterans Affairs;
   Veterans Health Administration (VHA); Durham VA Medical Center
RP Andonian, BJ (corresponding author), Duke Univ, Sch Med, Duke Mol Physiol Inst, Durham, NC 27708 USA.
EM brian.andonian@duke.edu
RI Kraus, William/J-1411-2012; Connelly, Margery/IZP-5440-2023
OI Andonian, Brian/0000-0003-1847-0660; Pieper, Carl/0000-0003-4809-1725
FU American Heart Association; Duke University Division of Rheumatology and
   Immunology; Duke Molecular Physiology Biomarkers Core
FX Original figure art was created with . The authors appreciate the
   support of the Duke University Division of Rheumatology and Immunology.
   We acknowledge the Duke Center for Living research staff members for
   their help with participant recruitment, intervention implementation and
   with recording of data. We acknowledge the Duke Molecular Physiology
   Biomarkers Core for their support and assistance with lab-based
   analyses. We acknowledge and appreciate greatly all participants in the
   study.
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NR 54
TC 2
Z9 2
U1 2
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
EI 2578-5745
J9 ACR OPEN RHEUMATOL
JI ACR Open Rheumatol.
PD MAR
PY 2024
VL 6
IS 3
BP 124
EP 136
DI 10.1002/acr2.11639
EA DEC 2023
PG 13
WC Rheumatology
WE Emerging Sources Citation Index (ESCI)
SC Rheumatology
GA KO6O2
UT WOS:001128609600001
PM 38126260
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Saini, RK
   Ranjit, A
   Sharma, K
   Prasad, P
   Shang, XM
   Gowda, KGM
   Keum, YS
AF Saini, Ramesh Kumar
   Ranjit, Arina
   Sharma, Kavita
   Prasad, Parchuri
   Shang, Xiaomin
   Gowda, Karekal Girinur Mallikarjuna
   Keum, Young-Soo
TI Bioactive Compounds of Citrus Fruits: A Review of Composition and Health
   Benefits of Carotenoids, Flavonoids, Limonoids, and Terpenes
SO ANTIOXIDANTS
LA English
DT Review
DE orange; mandarin; polymethoxylated flavones (PMFs); nobiletin; essential
   oil; beta-citraurin; limonene; metabolic syndrome; neurodegenerative
   diseases; cardiovascular disease (CVD)
ID OXIDATIVE STRESS; ESSENTIAL OILS; DIABETIC-RATS; IN-VIVO; ANTIOXIDANT;
   L.; EXTRACT; BIOAVAILABILITY; BIOSYNTHESIS; INFLAMMATION
AB The increased consumption of fruits, vegetables, and whole grains contributes to the reduced risk of many diseases related to metabolic syndrome, including neurodegenerative diseases, cardiovascular disease (CVD), diabetes, and cancer. Citrus, the genus Citrus L., is one of the most important fruit crops, rich in carotenoids, flavonoids, terpenes, limonoids, and many other bioactive compounds of nutritional and nutraceutical value. Moreover, polymethoxylated flavones (PMFs), a unique class of bioactive flavonoids, abundantly occur in citrus fruits. In addition, citrus essential oil, rich in limonoids and terpenes, is an economically important product due to its potent antioxidant, antimicrobial, and flavoring properties. Mechanistic, observational, and intervention studies have demonstrated the health benefits of citrus bioactives in minimizing the risk of metabolic syndrome. This review provides a comprehensive view of the composition of carotenoids, flavonoids, terpenes, and limonoids of citrus fruits and their associated health benefits.
C1 [Saini, Ramesh Kumar; Keum, Young-Soo] Konkuk Univ, Dept Crop Sci, Seoul 143701, South Korea.
   [Ranjit, Arina; Sharma, Kavita] Coll Pharm, Kasiska Div Hlth Sci, Biomed & Pharmaceut Sci, Pocatello, ID 83209 USA.
   [Prasad, Parchuri] Washington State Univ, Inst Biol Chem, Pullman, WA 99164 USA.
   [Shang, Xiaomin] Jilin Univ, Jilin Prov Key Lab Nutr & Funct Food, Changchun 130062, Peoples R China.
   [Gowda, Karekal Girinur Mallikarjuna] Padmashree Inst Management & Sci, Dept Biochem, Bengaluru 560060, India.
C3 Konkuk University; Washington State University; Jilin University
RP Keum, YS (corresponding author), Konkuk Univ, Dept Crop Sci, Seoul 143701, South Korea.
EM saini1997@konkuk.ac.kr; arinaranjit@isu.edu; sharkum2@isu.edu;
   prasad.parchuri@wsu.edu; xmshang@jlu.edu.cn;
   mallikarjunagowda367@gmail.com; rational@konkuk.ac.kr
RI Sharma, Kumari/AAF-5833-2020; Saini, Ramesh Kumar/KFA-4699-2024; Saini,
   Ramesh Kumar/L-4467-2017; P, Prasad/J-5244-2013
OI Saini, Ramesh Kumar/0000-0001-9052-9941; Sharma,
   Kavita/0000-0002-2796-9896; P, Prasad/0000-0002-9648-7487; Ranjit,
   Arina/0000-0001-9382-9800
FU Konkuk University research fund [2021A0190061]
FX This work and article processing charges (APC) were supported by the
   Konkuk University research fund (2021A0190061).
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NR 134
TC 227
Z9 237
U1 58
U2 384
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD FEB
PY 2022
VL 11
IS 2
AR 239
DI 10.3390/antiox11020239
PG 27
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA ZN8EC
UT WOS:000765259600001
PM 35204122
OA gold, Green Published
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Guo, YR
   Lee, HC
   Lo, YC
   Yu, SC
   Huang, SY
AF Guo, Yu-Ru
   Lee, Hsiu-Chuan
   Lo, Yun-Chun
   Yu, Shao-Chuan
   Huang, Shih-Yi
TI n-3 polyunsaturated fatty acids prevent D-galactose-induced cognitive
   deficits in prediabetic rats
SO FOOD & FUNCTION
LA English
DT Article
ID METABOLIC SYNDROME; OXIDATIVE STRESS; ADVANCED GLYCATION; DOUBLE-BLIND;
   OMEGA-3-FATTY-ACIDS; OBESITY; AGE; EXPRESSION; INSULIN; MEMORY
AB Nutritional deficit of n-3 polyunsaturated fatty acids (PUFAs) is closely related to cognitive impairment and depression in later life. Cognitive impairment and depression lead to comorbidities, such as metabolic syndrome, in elderly people. The aim of this study is to evaluate the effects of dietary n-3 PUFAs on cognition and depressive-like behavior in an accelerated senescence rat model with prediabetic status. Rats were cotreated with D-gal and sucrose solution for 7 months and then fed fish-oil- or flaxseed-oil-rich diets for 3 months. Cognitive impairment analysis and depressive-like behavioral testing were conducted using the Morris water maze (MWM) test and forced swimming test (FST), respectively. The MWM test results revealed that the D-gal + sucrose + flaxseed oil (DSFS) group had a significantly shorter mean latency time in the short-term spatial memory trial on day 2 than did the D-gal + sucrose l fish oil (DSFO) group. The FST results demonstrated that the DSFO group exhibited a significantly shorter immobility time and longer climbing time than did the control group. Western blot analysis of the receptor for advanced glycation end-product (RAGE) level identified a significant difference in the DSFO group compared with the control group. Significantly lower n-6/n-3 PUFA ratios were observed in the frontal cortices of the DSFO and DSFS groups. In conclusion, fish and flaxseed oils exerted a protective effect on cognitive impairment and decreased the incidence of depressive-like behavior in o-gal- and sucrose-fed prediabetic aging rats. n-3 PUFA-rich oil diets, particularly the fish oil diet, reduced the plasma levels of nonesterified fatty acids, tumor necrosis factor-alpha, and brain dopamine and RAGE expression but not glycemic status, resulting in an improvement in the time of escape latency and the time spent in the target quadrant in the MWM test.
C1 [Guo, Yu-Ru; Lee, Hsiu-Chuan; Lo, Yun-Chun; Yu, Shao-Chuan; Huang, Shih-Yi] Taipei Med Univ, Sch Nutr & Hlth Sci, Taipei, Taiwan.
   [Huang, Shih-Yi] Taipei Med Univ, Grad Inst Metab & Obes Sci, Taipei, Taiwan.
   [Huang, Shih-Yi] Taipei Med Univ Hosp, Res Ctr, Taipei, Taiwan.
C3 Taipei Medical University; Taipei Medical University; Taipei Medical
   University; Taipei Medical University Hospital
RP Huang, SY (corresponding author), Taipei Med Univ, Sch Nutr & Hlth Sci, Taipei, Taiwan.; Huang, SY (corresponding author), Taipei Med Univ, Grad Inst Metab & Obes Sci, Taipei, Taiwan.; Huang, SY (corresponding author), Taipei Med Univ Hosp, Res Ctr, Taipei, Taiwan.
EM sihuang@tmu.edu.tw
RI Huang, Shih-Yi/R-3495-2018
OI Huang, Shih-Yi/0000-0003-2914-5513; Guo, Yu-Ru/0000-0003-0093-8368
FU Ministry of Science and Technology, Taiwan [NSC102-2313-B-038-003-MY2,
   MOST103-2320-B-038-012-MY3, MOST106-2314-B-038-049,
   MOST106-2320-B-038-062-MY3]
FX This study was supported by grants (NSC102-2313-B-038-003-MY2,
   MOST103-2320-B-038-012-MY3, MOST106-2314-B-038-049 and
   MOST106-2320-B-038-062-MY3) from the Ministry of Science and Technology,
   Taiwan.
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PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
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SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PD APR 1
PY 2018
VL 9
IS 4
BP 2228
EP 2239
DI 10.1039/c8fo00074c
PG 12
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA GK3GV
UT WOS:000436031600027
PM 29552684
DA 2025-06-11
ER

PT J
AU Deussing, JM
   Chen, A
AF Deussing, Jan M.
   Chen, Alon
TI THE CORTICOTROPIN-RELEASING FACTOR FAMILY: PHYSIOLOGY OF THE STRESS
   RESPONSE
SO PHYSIOLOGICAL REVIEWS
LA English
DT Review
AB The physiological stress response is responsible for the maintenance of homeostasis in the presence of real or perceived challenges. In this function, the brain activates adaptive responses that involve numerous neural circuits and effector molecules to adapt to the current and future demands. A maladaptive stress response has been linked to the etiology of a variety of disorders, such as anxiety and mood disorders, eating disorders, and the metabolic syndrome. The neuropeptide corticotropin-releasing factor (CRF) and its relatives, the urocortins 1-3, in concert with their receptors (CRFR1, CRFR2), have emerged as central components of the physiological stress response. This central peptidergic system impinges on a broad spectrum of physiological processes that are the basis for successful adaptation and concomitantly integrate autonomic, neuroendocrine, and behavioral stress responses. This review focuses on the physiology of CRF-related peptides and their cognate receptors with the aim of providing a comprehensive up-to-date overview of the field. We describe the major molecular features covering aspects of gene expression and regulation, structural properties, and molecular interactions, as well as mechanisms of signal transduction and their surveillance. In addition, we discuss the large body of published experimental studies focusing on state-of-the-art genetic approaches with high temporal and spatial precision, which collectively aimed to dissect the contribution of CRF-related ligands and receptors to different levels of the stress response. We discuss the controversies in the field and unravel knowledge gaps that might pave the way for future research directions and open up novel opportunities for therapeutic intervention.
C1 [Deussing, Jan M.] Max Planck Inst Psychiat, Dept Stress Neurobiol & Neurogenet, Munich, Germany.
   Weizmann Inst Sci, Dept Neurobiol, Rehovot, Israel.
C3 Max Planck Society; Weizmann Institute of Science
RP Deussing, JM (corresponding author), Max Planck Inst Psychiat, Dept Stress Neurobiol & Neurogenet, Munich, Germany.
RI Deussing, Jan/ABB-5993-2021
FU FP7 Grant from the European Research Council [260463]; Israel Science
   Foundation [1565/15, 1916/12]; ERANET Program - Israeli Ministry of
   Health; Federal Ministry of Education and Research [01KU1501A]; I-CORE
   Program of the Planning and Budgeting Committee [1916/12]; Nella and
   Leon Benoziyo Center for Neurological Diseases; Henry Chanoch Krenter
   Institute for Biomedical Imaging and Genomics; Perlman Family
   Foundation; Adelis Foundation; Marc Besen and the Pratt Foundation;
   Irving I. Moskowitz Foundation; German Federal Ministry of Education and
   Research [FKZ 01ZX1314H]; Marie SklodowskaCurie innovative training
   network PurinesDX; program supporting scientific and technological
   cooperation between Germany and Argentina [FKZ 01DN16028]; European
   Research Council (ERC) [260463] Funding Source: European Research
   Council (ERC)
FX This work is supported by an FP7 Grant from the European Research
   Council (260463, A. Chen); a research grant from the Israel Science
   Foundation (1565/15, A. Chen); the ERANET Program, supported by the
   Chief Scientist Office of the Israeli Ministry of Health (A. Chen). The
   project was funded by the Federal Ministry of Education and Research
   under the funding code 01KU1501A (A. Chen); research support from
   Roberto and Renata Ruhman (A. Chen); research support from Bruno and
   Simone Licht; I-CORE Program of the Planning and Budgeting Committee and
   The Israel Science Foundation (Grant 1916/12 to A. Chen); the Nella and
   Leon Benoziyo Center for Neurological Diseases (A. Chen); the Henry
   Chanoch Krenter Institute for Biomedical Imaging and Genomics (A. Chen);
   the Perlman Family Foundation, founded by Louis L, Anita M. Perlman (A.
   Chen); the Adelis Foundation (A. Chen); the Marc Besen and the Pratt
   Foundation (A. Chen); the Irving I. Moskowitz Foundation (A. Chen); the
   German Federal Ministry of Education and Research, within the framework
   of the e:Med research and funding concept (IntegraMent: FKZ 01ZX1314H,
   J. M. Deussing), the Marie SklodowskaCurie innovative training network
   PurinesDX (J. M. Deussing); and by the program supporting scientific and
   technological cooperation between Germany and Argentina (FKZ 01DN16028,
   J. M. Deussing).
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NR 684
TC 166
Z9 173
U1 0
U2 14
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0031-9333
EI 1522-1210
J9 PHYSIOL REV
JI Physiol. Rev.
PD OCT
PY 2018
VL 98
IS 4
BP 2225
EP 2286
DI 10.1152/physrev.00042.2017
PG 62
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA VJ1UG
UT WOS:000548294200001
PM 30109816
OA Bronze
DA 2025-06-11
ER

PT J
AU Abdelmalek, MF
   Diehl, AM
AF Abdelmalek, Manal F.
   Diehl, Anna Mae
TI Nonalcoholic fatty liver disease as a complication of insulin resistance
SO MEDICAL CLINICS OF NORTH AMERICA
LA English
DT Review
ID MORBIDLY OBESE-PATIENTS; WEIGHT-LOSS; METABOLIC SYNDROME;
   NATURAL-HISTORY; HEPATIC STEATOSIS; CONTROLLED-TRIAL; LIFE-STYLE;
   CRYPTOGENIC CIRRHOSIS; URSODEOXYCHOLIC ACID; ADIPOSE-TISSUE
AB Nonalcoholic fatty liver disease (NAFLD) refers to a spectrum of liver damage ranging from simple steatosis to nonalcoholic steatohepatitis, advanced fibrosis, and rarely, progression to cirrhosis. The pathogenesis of NAFLD is thought to be related to insulin resistance and oxidant stress. Truncal obesity, dyslipidema, hypertension, and hyperglycemia are strongly associated with NAFLD; therefore, management of NAFLD entails identification and treatment of metabolic risk factors, improving insulin sensitivity, and increasing antioxidant defenses in the liver. This article briefly summarizes advances in our understanding of the relationship between NAFLD and the insulin resistance (metabolic) syndrome, its prevalence, natural history, and treatment.
C1 Duke Univ, Med Ctr, Div Gastroenterol Hepatol & Nutr, Durham, NC 27710 USA.
C3 Duke University
RP Abdelmalek, MF (corresponding author), Duke Univ, Med Ctr, Div Gastroenterol Hepatol & Nutr, POB 3913, Durham, NC 27710 USA.
EM manal.abdelmalek@duke.edu
RI Abdelmalek, Manal/AAW-2203-2020
OI Abdelmalek, Manal/0000-0002-5001-8618
FU NIDDK NIH HHS [5K23-DK062116, 5U01-DK061713, 5R01-DK053792] Funding
   Source: Medline
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NR 125
TC 127
Z9 155
U1 0
U2 7
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0025-7125
EI 1557-9859
J9 MED CLIN N AM
JI Med. Clin. N. Am.
PD NOV
PY 2007
VL 91
IS 6
BP 1125
EP +
DI 10.1016/j.mcna.2007.06.001
PG 26
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 235HO
UT WOS:000251224600009
PM 17964913
DA 2025-06-11
ER

PT J
AU Raja, R
   Fonseka, O
   Ganenthiran, H
   Andrea-Ruiz-Velasco
   Liu, W
AF Raja, Rida
   Fonseka, Oveena
   Ganenthiran, Haresh
   Andrea-Ruiz-Velasco
   Liu, Wei
TI The multifaceted roles of ER and Golgi in metabolic cardiomyopathy
SO FRONTIERS IN CARDIOVASCULAR MEDICINE
LA English
DT Review
DE metabolic syndrome; metabolic cardiomyopathy; cardiac lipid metabolism;
   endoplasmic reticulum; Golgi apparatus
ID ENDOPLASMIC-RETICULUM STRESS; UNFOLDED PROTEIN RESPONSE; FATTY-ACID
   OXIDATION; INSULIN-RESISTANCE; LIPID-METABOLISM; HEART-FAILURE;
   DIABETES-MELLITUS; CELL-DEATH; DEGRADATION; APOPTOSIS
AB Metabolic cardiomyopathy is a significant global financial and health challenge; however, pathophysiological mechanisms governing this entity remain poorly understood. Among the main features of metabolic cardiomyopathy, the changes to cellular lipid metabolism have been studied and targeted for the discovery of novel treatment strategies obtaining contrasting results. The endoplasmic reticulum (ER) and Golgi apparatus (GA) carry out protein modification, sorting, and secretion activities that are more commonly studied from the perspective of protein quality control; however, they also drive the maintenance of lipid homeostasis. In response to metabolic stress, ER and GA regulate the expression of genes involved in cardiac lipid biogenesis and participate in lipid droplet formation and degradation. Due to the varied roles these organelles play, this review will focus on recapitulating the alterations and crosstalk between ER, GA, and lipid metabolism in cardiac metabolic syndrome.
C1 [Raja, Rida; Fonseka, Oveena; Ganenthiran, Haresh; Andrea-Ruiz-Velasco; Liu, Wei] Univ Manchester, Fac Biol Med & Hlth, Manchester, England.
C3 University of Manchester
RP Andrea-Ruiz-Velasco; Liu, W (corresponding author), Univ Manchester, Fac Biol Med & Hlth, Manchester, England.
EM andrea.ruiz@manchester.ac.uk; wei.liu@manchester.ac.uk
OI Fonseka, Oveena/0009-0009-9949-7689; Ruiz-Velasco,
   Andrea/0000-0003-0660-5855; Liu, Wei/0000-0003-1592-6693
FU British Heart Foundation;  [FS/15/16/31477];  [FS/18/73/33973]; 
   [PG/19/66/34600];  [FS/19/70/34650]
FX Funding This work as supported by grants FS/15/16/31477, FS/18/73/33973,
   PG/19/66/34600, and FS/19/70/34650 to WL from the British Heart
   Foundation.
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NR 93
TC 4
Z9 4
U1 0
U2 12
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2297-055X
J9 FRONT CARDIOVASC MED
JI Front. Cardiovasc. Med.
PD SEP 2
PY 2022
VL 9
AR 999044
DI 10.3389/fcvm.2022.999044
PG 9
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 5N2HS
UT WOS:000871610600001
PM 36119738
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Pistollato, F
   Battino, M
AF Pistollato, Francesca
   Battino, Maurizio
TI Role of plant-based diets in the prevention and regression of metabolic
   syndrome and neurodegenerative diseases
SO TRENDS IN FOOD SCIENCE & TECHNOLOGY
LA English
DT Review
ID GLYCATION END-PRODUCTS; SERUM LDL CHOLESTEROL; SYNDROME RISK-FACTORS;
   SOY PROTEIN; OXIDATIVE STRESS; CALORIC RESTRICTION; INSULIN-RESISTANCE;
   PARKINSONS-DISEASE; PHYSICAL-ACTIVITY; VEGETARIAN DIET
AB Plant-based diets are known to preserve body tissues from oxidative stress and inflammation, both hallmarks of chronicdegenerative diseases. In particular, plant-derived foods, such as legumes, represent a natural source of bioactive nutrients known to contribute to the prevention and amelioration of insulin resistance, dyslipidemia, hypertension and impaired glucose metabolism, all factors implicated in metabolic syndrome (MetS), but also osteoporosis, neurodegeneration and some types of cancers. Here we revise recent literature on the role of plant-based diets, plant-foods and specific plant-nutrients in the prevention and regression of MetS and neurodegenerative diseases. We describe some of the molecular mechanisms underlying these protective effects, highlighting the role of diet in the control of hyper-homocysteinemia and insulin resistance, often implicated in the etiology of both metabolic and neurodegenerative syndromes.
C1 [Pistollato, Francesca; Battino, Maurizio] Univ Politecn Marche, Dipartimento Sci Clin Specialist & Odontostomatol, Sez Biochim, Ancona, Italy.
   [Battino, Maurizio] UEA, Ctr Nutr & Hlth, Santander, Spain.
   [Battino, Maurizio] Univ Politecn Marche, Fac Med, Dipartimento Sci Clin Specialist & Odontostomatol, Sez Biochim, I-60100 Ancona, Italy.
C3 Marche Polytechnic University; Marche Polytechnic University
RP Battino, M (corresponding author), Univ Politecn Marche, Dipartimento Sci Clin Specialist & Odontostomatol, Sez Biochim, Ancona, Italy.
EM battino@univpm.it
RI Pistollato, Francesca/C-3142-2015; Battino, Maurizio/E-6103-2012
OI Pistollato, Francesca/0000-0003-0288-9539; Battino,
   Maurizio/0000-0002-7250-1782
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NR 142
TC 52
Z9 58
U1 1
U2 47
PU ELSEVIER SCIENCE LONDON
PI LONDON
PA 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND
SN 0924-2244
EI 1879-3053
J9 TRENDS FOOD SCI TECH
JI Trends Food Sci. Technol.
PD NOV
PY 2014
VL 40
IS 1
BP 62
EP 81
DI 10.1016/j.tifs.2014.07.012
PG 20
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA AU3XA
UT WOS:000345542800005
DA 2025-06-11
ER

PT J
AU Simmons, R
AF Simmons, R
TI Developmental origins of adult metabolic disease
SO ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA
LA English
DT Article
ID INTRAUTERINE GROWTH-RETARDATION; DEPENDENT DIABETES-MELLITUS; PANCREATIC
   BETA-CELLS; LOW-BIRTH-WEIGHT; IMPAIRED OXIDATIVE-PHOSPHORYLATION;
   SIGNALING PROTEIN EXPRESSION; THRIFTY PHENOTYPE HYPOTHESIS;
   INSULIN-RESISTANCE SYNDROME; ENZYME GENE-EXPRESSION; FOR-GESTATIONAL-AGE
AB The combined epidemiologic, clinical, and animal studies clearly demonstrate that the intrauterine environment influences growth and development of the fetus and the subsequent development of adult diseases. There are critical specific windows during development, often coincident with periods of rapid cell division, during which a stimulus or insult may have long-lasting consequences on tissue or organ function after birth. Birth weight is only one marker of an adverse fetal environment, and confining studies to this population only may lead to erroneous conclusions regarding etiology. Studies using animal models of uteroplacental insufficiency suggest that mitochondrial dysfunction and oxidative stress play an important role in the pathogenesis of the fetal origins of adult disease.
C1 Univ Penn, Philadelphia, PA 19104 USA.
   Childrens Hosp Philadelphia, Dept Pediat, Philadelphia, PA 19104 USA.
C3 University of Pennsylvania; University of Pennsylvania; Pennsylvania
   Medicine; Childrens Hospital of Philadelphia
RP Univ Penn, 421 Curie Blvd,BRB 11-111,Room 1308, Philadelphia, PA 19104 USA.
EM rsimmons@mail.med.upenn.edu
OI Simmons, Rebecca/0000-0002-2901-8904
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NR 94
TC 23
Z9 30
U1 0
U2 3
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0889-8529
EI 1558-4410
J9 ENDOCRIN METAB CLIN
JI Endocrinol. Metabol. Clin. North Amer.
PD MAR
PY 2006
VL 35
IS 1
BP 193
EP +
DI 10.1016/j.ecl.2005.09.006
PG 13
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 997YT
UT WOS:000234285600012
PM 16310649
DA 2025-06-11
ER

PT J
AU Grabowska, M
   Wawrzyniak, D
   Rolle, K
   Chomczynski, P
   Oziewicz, S
   Jurga, S
   Barciszewski, J
AF Grabowska, Malgorzata
   Wawrzyniak, Dariusz
   Rolle, Katarzyna
   Chomczynski, Piotr
   Oziewicz, Stefan
   Jurga, Stefan
   Barciszewski, Jan
TI Let food be your medicine: nutraceutical properties of lycopene
SO FOOD & FUNCTION
LA English
DT Review
ID NF-KAPPA-B; PROSTATE-SPECIFIC ANTIGEN; BREAST-CANCER; OXIDATIVE STRESS;
   BETA-CAROTENE; DNA-DAMAGE; APO-10'-LYCOPENOIC ACID; PLASMA CAROTENOIDS;
   METABOLIC SYNDROME; GENE METHYLATION
AB Currently, an increase in the awareness of a healthy lifestyle has been observed in society. People are seeking added health benefits from their dietary intake. Thus, functional foods with supplemented components that promote wellness are becoming popular. Lycopene is a carotenoid that gives vegetables and fruits their red color. Due to its chemical structure, lycopene acts as an antioxidant, which is the basis for its health-promoting properties. Oxidative stress is recognized as an important agent of many chronic diseases; thus, lycopene appears to be a universal medicine. Lycopene has the greatest antioxidant potential among carotenoids. Nutraceutical effects of lycopene have been reported for patients with cancer, infertility, metabolic syndrome and liver damage. Therefore, its supplementation can function as a proper causative treatment of disease. In this review, we highlight primary research and clinical trials involving lycopene and its impact on human health.
C1 [Grabowska, Malgorzata; Wawrzyniak, Dariusz; Rolle, Katarzyna; Barciszewski, Jan] Polish Acad Sci, Inst Bioorgan Chem, Noskowskiego 12-14, PL-61704 Poznan, Poland.
   [Rolle, Katarzyna] Adam Mickiewicz Univ, Ctr Adv Technol, Umultowska 89 C, PL-61614 Poznan, Poland.
   [Chomczynski, Piotr] Mol Res Ctr, Cincinnati, OH 45212 USA.
   [Oziewicz, Stefan] Cinna Prod Zdrowia, Poznanska 88, PL-62020 Pobiedziska, Poland.
   [Jurga, Stefan; Barciszewski, Jan] Adam Mickiewicz Univ, NanoBioMed Ctr, Umultowska 85, PL-61614 Poznan, Poland.
C3 Polish Academy of Sciences; Adam Mickiewicz University; Adam Mickiewicz
   University
RP Barciszewski, J (corresponding author), Polish Acad Sci, Inst Bioorgan Chem, Noskowskiego 12-14, PL-61704 Poznan, Poland.; Barciszewski, J (corresponding author), Adam Mickiewicz Univ, NanoBioMed Ctr, Umultowska 85, PL-61614 Poznan, Poland.
EM Jan.Barciszewski@ibch.poznan.pl
RI Wawrzyniak, Dariusz/IZE-5464-2023; Rolle, Katarzyna/HNB-6175-2023;
   Grabowska, Małgorzata/ABD-9470-2021; Jurga, Stefan/E-8862-2017
OI Grabowska, Malgorzata/0000-0002-2711-1910; Jurga,
   Stefan/0000-0002-1665-6077; Wawrzyniak, Dariusz/0000-0002-6128-5383;
   Barciszewski, Jan/0000-0001-7766-5594
FU Ministry of Science and Higher Education of the Republic of Poland by
   KNOW program
FX This work was supported by the Ministry of Science and Higher Education
   of the Republic of Poland by KNOW program.
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NR 130
TC 118
Z9 123
U1 1
U2 83
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PD JUN 1
PY 2019
VL 10
IS 6
BP 3090
EP 3102
DI 10.1039/c9fo00580c
PG 13
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA IK4BD
UT WOS:000476531200004
PM 31120074
DA 2025-06-11
ER

PT J
AU Cretenet, G
   Le Clech, M
   Gachon, F
AF Cretenet, Gaspard
   Le Clech, Mikael
   Gachon, Frederic
TI Circadian Clock-Coordinated 12 Hr Period Rhythmic Activation of the
   IRE1α Pathway Controls Lipid Metabolism in Mouse Liver
SO CELL METABOLISM
LA English
DT Article
ID ENDOPLASMIC-RETICULUM STRESS; UNFOLDED PROTEIN RESPONSE; ELEMENT-BINDING
   PROTEIN; MESSENGER-RNA; ER STRESS; TRANSCRIPTION FACTOR; RAT-LIVER;
   EXPRESSION; INHIBITION; GLYCOGEN
AB The mammalian circadian clock plays a fundamental role in the liver by regulating fatty acid, glucose, and xenobiotic metabolism. Impairment of this rhythm has been shown to lead to diverse pathologies, including metabolic syndrome. Currently, it is supposed that the circadian clock regulates metabolism mostly by regulating expression of liver enzymes at the transcriptional level. Here, we show that the circadian clock also controls hepatic metabolism by synchronizing a secondary 12 hr period rhythm characterized by rhythmic activation of the IRE1 alpha pathway in the endoplasmic reticulum. The absence of circadian clock perturbs this secondary clock and provokes deregulation of endoplasmic reticulum-localized enzymes. This leads to impaired lipid metabolism, resulting in aberrant activation of the sterol-regulated SREBP transcription factors. The resulting aberrant circadian lipid metabolism in mice devoid of the circadian clock could be involved in the appearance of the associated metabolic syndrome.
C1 [Cretenet, Gaspard; Le Clech, Mikael; Gachon, Frederic] CNRS, UPR 1142, Inst Genet Humaine, F-34396 Montpellier, France.
C3 Universite de Montpellier; Centre National de la Recherche Scientifique
   (CNRS)
RP Gachon, F (corresponding author), Univ Lausanne, Dept Pharmacol & Toxicol, CH-1005 Lausanne, Switzerland.
RI Gachon, Frederic/H-3111-2019
OI Gachon, Frederic/0000-0002-9279-9707
FU Inserm; "Fondation pour la Recherche Medicale"; "Association pour la
   Recherche sur le Cancer"; Languedoc Roussillon
FX We thank Angelique Bruyer, Mayssa Chawaf, Vuthy Ea, and Geraldine Bello
   for technical assistance. and Patrick Alger for his expert preparation
   of the artwork We are very grateful to Xavier Bonnefont and Isabelle Bur
   for Cry1/Cry2 knockout mice and for critical reading of the manuscript
   We also want to thank Joseph Takahashi for liver mRNA from Clock Delta
   19 mice, and David Weaver and Dmitri Firsov for giving us access to
   Clock knockout mice Ire1 alpha. cDNA was kindly provided by David Ron We
   want to thank Ueli Schibler, Vjekoslav Dulic, and Rosemary Kiernan for
   critical reading of this manuscript. and John Hogenesch for sharing
   unpublished data with us This research was supported by Inserm through
   the Avenir program, the "Fondation pour la Recherche Medicale," and the
   "Association pour la Recherche sur le Cancer" G C is supported by a
   grant from Inserm and region Languedoc Roussillon M LeC. is supported by
   Inserm
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U2 18
PU CELL PRESS
PI CAMBRIDGE
PA 50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA
SN 1550-4131
EI 1932-7420
J9 CELL METAB
JI Cell Metab.
PD JAN 6
PY 2010
VL 11
IS 1
BP 47
EP 57
DI 10.1016/j.cmet.2009.11.002
PG 11
WC Cell Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Endocrinology & Metabolism
GA 543YJ
UT WOS:000273617000009
PM 20074527
OA Green Submitted, Bronze
DA 2025-06-11
ER

PT J
AU Datz, C
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   Niederseer, D
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AF Datz, Christian
   Felder, Thomas K.
   Niederseer, David
   Aigner, Elmar
TI Iron homeostasis in the Metabolic Syndrome
SO EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
LA English
DT Review
DE FPN - ferroportin-1; hepcidin; iron overload; metabolic syndrome;
   non-alcoholic fatty liver disease
ID NONALCOHOLIC FATTY LIVER; SERUM FERRITIN CONCENTRATION;
   INSULIN-RESISTANCE; HEPATIC IRON; HEREDITARY HEMOCHROMATOSIS; OXIDATIVE
   STRESS; OVERLOAD SYNDROME; HFE MUTATIONS; DISEASE RISK; HEPCIDIN
AB The metabolic syndrome (MetS) affects iron homeostasis in a many-faceted fashion. On the one side, hyperferritinaemia with normal or mildly elevated transferrin saturation is observed in approximately one-third of patients with non-alcoholic fatty liver disease (NAFLD) or the MetS. This constellation has been named the dysmetabolic iron overload syndrome (DIOS). Current evidence suggests that elevated body iron stores exert a detrimental effect on the clinical course of obesity-related conditions and that iron removal improves insulin sensitivity and delays the onset of T2DM. On the other side, iron deficiency is a frequent finding in more progressed stages of obesity. The mechanisms underlying the DIOS and obesity-related iron deficiency appear strikingly similar as elevated hepcidin concentrations, low expression of duodenal ferroportin (FPN) and impaired iron absorption are found in both conditions. This review summarizes the current knowledge about the dysregulation of iron homeostasis in the MetS and particularly in its hepatic manifestation NAFLD.
C1 [Datz, Christian; Niederseer, David] Gen Hosp Oberndorf, Dept Internal Med, A-5110 Oberndorf, Austria.
   [Felder, Thomas K.] Paracelsus Med Univ, Dept Lab Med, A-5020 Salzburg, Austria.
   [Aigner, Elmar] Paracelsus Med Univ, Dept Med 1, A-5020 Salzburg, Austria.
C3 Paracelsus Private Medical University; Paracelsus Private Medical
   University
RP Aigner, E (corresponding author), Paracelsus Med Univ, Dept Med 1, Mullner Hauptstr 48, A-5020 Salzburg, Austria.
EM c.datz@kh-obdf.salzburg.at; e.aigner@salk.at
RI Felder, Thomas/A-8342-2017; Niederseer, David/X-7363-2018
OI Felder, Thomas/0000-0001-8266-5513; Niederseer,
   David/0000-0003-3089-1222
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NR 72
TC 133
Z9 139
U1 0
U2 37
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0014-2972
J9 EUR J CLIN INVEST
JI Eur. J. Clin. Invest.
PD FEB
PY 2013
VL 43
IS 2
BP 215
EP 224
DI 10.1111/eci.12032
PG 10
WC Medicine, General & Internal; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Research & Experimental Medicine
GA 074NA
UT WOS:000313818000013
PM 23289518
DA 2025-06-11
ER

PT J
AU Kuehl, LK
   Muhtz, C
   Hinkelmann, K
   Dettenborn, L
   Wingenfeld, K
   Spitzer, C
   Otte, C
AF Kuehl, Linn K.
   Muhtz, Christoph
   Hinkelmann, Kim
   Dettenborn, Lucia
   Wingenfeld, Katja
   Spitzer, Carsten
   Otte, Christian
TI Association between major depression and cardiovascular risk: the role
   of antidepressant medication
SO PSYCHOPHARMACOLOGY
LA English
DT Article
DE Major depression; Antidepressants; Cardiovascular risk; Blood pressure;
   Glucose; Body mass index
ID CORONARY-HEART-DISEASE; MYOCARDIAL-INFARCTION; METABOLIC SYNDROME;
   PROSPECTIVE COHORT; BLOOD-PRESSURE; METAANALYSIS; ANXIETY; MORTALITY;
   EVENTS; HYPERTENSION
AB Major depressive disorder (MDD) is associated with an increased risk for cardiovascular disease (CVD). Apart from biological and life style factors, the use of antidepressants and their potentially adverse effects might contribute to the increased CVD risk. Therefore, we compared cardiovascular risk profiles between relatively young depressed patients without CVD with and without antidepressant medication and healthy participants.
   We investigated 44 depressed patients (with antidepressants N = 20 (13 women), mean age 43.2 years; without antidepressants N = 24 (15 women), mean age 40.0) and 41 healthy participants (matched for sex, age, education). As markers of CVD risk, blood pressure, body mass index (BMI), and plasma levels of fasting glucose, cholesterol, low density lipoprotein (LDL), high density lipoprotein (HDL), and high sensitivity C-reactive protein (h-CRP) were measured.
   We found significant differences between groups for BMI (p < .01), systolic (p = .02) and diastolic blood pressure (p < .01), and glucose (p < .001). Post hoc analyses indicated differences between both patient groups compared to the healthy control group, but not between patients groups. Further controlling for BMI diminished the effect of diagnosis on blood pressure; however, this was not the case for glucose level. There were no between-group differences in cholesterol, LDL, HDL, and h-CRP.
   We found a clearly increased CVD risk in this group of rather young depressed patients. Importantly, there was no significant difference in CVD risk between patients with vs. without antidepressants. This suggests that major depression per se and not antidepressant medication is associated with increased CVD risk.
C1 [Kuehl, Linn K.; Hinkelmann, Kim; Wingenfeld, Katja; Otte, Christian] Charite Univ Med Sch Berlin, Dept Psychiat, Campus Benjamin Franklin, Berlin, Germany.
   [Muhtz, Christoph] Univ Med Ctr Hamburg Eppendorf, Dept Psychosomat Med, Hamburg, Germany.
   [Dettenborn, Lucia] Univ Med Ctr Hamburg Eppendorf, Dept Med Psychol, Hamburg, Germany.
   [Spitzer, Carsten] Asklepios Fachklinikum Tiefenbrunn, Rosdorf, Germany.
C3 Berlin Institute of Health; Free University of Berlin; Humboldt
   University of Berlin; Charite Universitatsmedizin Berlin; University of
   Hamburg; University Medical Center Hamburg-Eppendorf; University of
   Hamburg; University Medical Center Hamburg-Eppendorf
RP Kuehl, LK (corresponding author), Charite Univ Med Sch Berlin, Dept Psychiat, Campus Benjamin Franklin, Berlin, Germany.
EM linn.kuehl@charite.de
OI Kuehl, Linn/0000-0001-6871-6302; Wingenfeld, Katja/0000-0001-7457-0370;
   Otte, Christian/0000-0002-4051-997X
FU Lundbeck; Servier
FX The authors received no funding. Dr. LK, Dr. CM, Dr. KH, Dr. LD, Dr. KW,
   and Dr. CS report no conflict of interest. Dr. CO has received honoria
   fees for lectures from Lundbeck and Servier.
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NR 51
TC 8
Z9 12
U1 1
U2 17
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0033-3158
EI 1432-2072
J9 PSYCHOPHARMACOLOGY
JI Psychopharmacology
PD SEP
PY 2016
VL 233
IS 18
BP 3289
EP 3295
DI 10.1007/s00213-016-4361-3
PG 7
WC Neurosciences; Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA DU3ZW
UT WOS:000382152300001
PM 27465410
DA 2025-06-11
ER

PT J
AU Biolo, G
   Di Girolamo, FG
   McDonnell, A
   Fiotti, N
   Meareili, F
   Situlin, R
   Gonelli, A
   Dapas, B
   Giordano, M
   Lainscak, M
   Grassi, G
   Zauli, G
   Secchiero, P
   Mekjavic, I
AF Biolo, Gianni
   Di Girolamo, Filippo G.
   McDonnell, Adam
   Fiotti, Nicola
   Meareili, Filippo
   Situlin, Roberta
   Gonelli, Arianna
   Dapas, Barbara
   Giordano, Mauro
   Lainscak, Mitja
   Grassi, Gabriele
   Zauli, Giorgio
   Secchiero, Paola
   Mekjavic, Igor
TI Effects of Hypoxia and Bed Rest on Markers of Cardiometabolic Risk:
   Compensatory Changes in Circulating TRAIL and Glutathione Redox Capacity
SO FRONTIERS IN PHYSIOLOGY
LA English
DT Article
DE hypoxia; TRAIL; glutathione; oxidative stress; bed rest; omega-3 fatty
   acids
ID APOPTOSIS-INDUCING LIGAND; CORONARY-HEART-DISEASE; OBSTRUCTIVE
   PULMONARY-DISEASE; ARTERY-DISEASE; ENERGY-BALANCE; ADIPOSE-TISSUE;
   INACTIVITY; ATHEROSCLEROSIS; METABOLISM; MORTALITY
AB In chronic diseases, hypoxia and physical inactivity are associated with atherosclerosis progression. In contrast, a lower mortality from coronary artery disease and stroke is observed in healthy humans residing at high altitude in hypoxic environments. Eleven young, male volunteers completed the following 10-day campaigns in a randomized order: hypoxic ambulatory, hypoxic bed rest and normoxic bed rest. Before intervention, subjects were evaluated in normoxic ambulatory condition. Normobaric hypoxia was achieved in a hypoxic facility simulating 4000 m of altitude. Following hypoxia, either in bed rest or ambulatory condition, markers of cardiometabolic risk shifted toward a more atherogenic pattern consisting of: (a) lower levels of total HDL cholesterol and HDL2 sub-fraction and decreased hepatic lipase; (b) activation of systemic inflammation, as determined by C-reactive protein and serum amyloid A; (c) increased plasma homocysteine; (d) decreased delta-5 desaturase index in cell membrane fatty acids, a marker of insulin sensitivity. Bed rest and hypoxia additively decreased total HDL and delta-5 desaturase index. In parallel to the pro-atherogenic effects, hypoxia activated selected anti-atherogenic pathways, consisting of increased circulating TNF-related apoptosis-inducmg ligand (TRAIL), a protective factor against atherosclerosis, membrane omega-3 index and erythrocyte glutathione availability. Hypoxia mediated changes in TRAIL concentrations and redox glutathione capacity (i.e., GSH/GSSG ratio) were greater in ambulatory conditions (+34 +/- 6% and +87 +/- 31 %, respectively) than in bed rest (+17 +/- 7% and +2 +/- 27% respectively). Hypoxia-induced cardiometabolic risk is blunted by moderate level of physical activity as compared to bed rest. TRAIL and glutathione redox capacity may contribute to the positive interaction between physical activity and hypoxia.
C1 [Biolo, Gianni; Di Girolamo, Filippo G.; Fiotti, Nicola; Meareili, Filippo; Situlin, Roberta] Univ Trieste, Dept Med Surg & Hlth Sci, Clin Med, Trieste, Italy.
   [McDonnell, Adam; Mekjavic, Igor] Jozef Stefan Inst, Dept Automat Biocybernet & Robot, Ljubljana, Slovenia.
   [Gonelli, Arianna; Zauli, Giorgio; Secchiero, Paola] Univ Ferrara, Dipartimento Morfol Chirurg & Med Sperimentale, Ferrara, Italy.
   [Dapas, Barbara; Grassi, Gabriele] Univ Trieste, Dept Life Sci, Trieste, Italy.
   [Giordano, Mauro] Univ Campania Luigi Vanvitelli, Osped Clin Marcianise, Dipartimento Sci Med Chirurg Neurol Metab & Invec, Marcianise, Italy.
   [Lainscak, Mitja] Univ Ljubljana, Dept Internal Med, Gen Hosp Murska Sobota, Ljubljana, Slovenia.
   [Lainscak, Mitja] Univ Ljubljana, Fac Med, Ljubljana, Slovenia.
C3 University of Trieste; Slovenian Academy of Sciences & Arts (SASA);
   Jozef Stefan Institute; University of Ferrara; University of Trieste;
   Universita della Campania Vanvitelli; University of Ljubljana;
   University of Ljubljana
RP Biolo, G (corresponding author), Univ Trieste, Dept Med Surg & Hlth Sci, Clin Med, Trieste, Italy.
EM biolo@units.it
RI Fiotti, Nicola/AEM-3887-2022; Di Girolamo, Filippo/AAY-3891-2020;
   Gonelli, Arianna/G-5551-2015; Zauli, Giorgio/ABE-8001-2020; Mekjavic,
   Igor/AAM-6962-2021; Biolo, Gianni/AAB-4983-2022; McDonnell,
   Adam/ABC-4445-2021
OI BIOLO, GIANNI/0000-0002-6397-1598; GRASSI, GABRIELE/0000-0001-9704-6651;
   McDonnell, Adam/0000-0003-3898-1759; Mearelli,
   Filippo/0000-0002-5862-9077; FIOTTI, NICOLA/0000-0001-8918-7622;
   GIORDANO, MAURO/0000-0001-8175-547X; de Glisezinski,
   Isabelle/0000-0002-3166-549X; Mekjavic, Igor/0000-0001-5930-2159; Di
   Girolamo, Filippo Giorgio/0000-0001-6000-5127
FU European Space Agency (ESA) Program for European Cooperating States
   (ESTEC) [40001043721/11/NL/KML]; Slovene Research Agency [L3-3654];
   European Union FP7 (PlanHab) [284438]; Italian Ministry of Education,
   University and Research - MIUR ("DEDIPAC" project: Decreto Direttoriale)
   [prot. 462]; Academy of Finland (AKA) [284438] Funding Source: Academy
   of Finland (AKA)
FX The study was supported, in part, by the European Space Agency (ESA)
   Program for European Cooperating States (ESTEC/Contract No.
   40001043721/11/NL/KML: Planetary Habitat Simulation), by the Slovene
   Research Agency (Grant No. L3-3654: Zero and reduced gravity simulation:
   The effect on the cardiovascular and musculoskeletal systems), and by
   the European Union FP7 (PlanHab; Grant No. 284438). This paper was
   supported by a grant from the Italian Ministry of Education, University
   and Research - MIUR ("DEDIPAC" project: Decreto Direttoriale no. prot.
   462 del 18/02/2014).
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NR 54
TC 13
Z9 14
U1 0
U2 5
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-042X
J9 FRONT PHYSIOL
JI Front. Physiol.
PD JUL 30
PY 2018
VL 9
AR 1000
DI 10.3389/fphys.2018.01000
PG 13
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA GO6ZS
UT WOS:000440204800001
PM 30104982
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Basu, A
   Sanchez, K
   Leyva, MJ
   Wu, MY
   Betts, NM
   Aston, CE
   Lyons, TJ
AF Basu, Arpita
   Sanchez, Karah
   Leyva, Misti J.
   Wu, Mingyuan
   Betts, Nancy M.
   Aston, Christopher E.
   Lyons, Timothy J.
TI Green Tea Supplementation Affects Body Weight, Lipids, and Lipid
   Peroxidation in Obese Subjects with Metabolic Syndrome
SO JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION
LA English
DT Article
ID RANDOMIZED CONTROLLED-TRIAL; CORONARY-ARTERY-DISEASE; OXIDATIVE STRESS;
   DIETARY-SUPPLEMENTS; DIABETIC-RATS; ABDOMINAL FAT; US ADULTS;
   CONSUMPTION; CATECHINS; INGESTION
AB Objective: To compare the effects of supplementation of green tea beverage or green tea extracts with controls on body weight, glucose and lipid profile, biomarkers of oxidative stress, and safety parameters in obese subjects with metabolic syndrome.
   Design: Randomized, controlled prospective trial.
   Setting: General Clinical Research Center (GCRC) at University of Oklahoma Health Sciences Center (OUHSC).
   Subjects: Thirty-five subjects with obesity and metabolic syndrome were recruited in age- and gender-matched trios and were randomly assigned to the control (4 cups water/d), green tea (4 cups/d), or green tea extract (2 capsules and 4 cups water/d) group for 8 weeks. The tea and extract groups had similar dosing of epiogallocatechin-3-gallate (EGCG), the active compound in green tea.
   Methods: Anthropometrics, blood pressure, fasting glucose and lipids, nuclear magnetic resonance (NMR) based lipid particle size, safety parameters, biomarkers of oxidative stress (oxidized low-density lipoprotein [LDL], myeloperoxidase [MPO], malondialdehyde and hydroxynonenals [MDA and HNE]), and free catechins were analyzed at screen and at 4 and 8 weeks of the study.
   Results: Pairwise comparisons showed green tea beverage and green tea extracts caused a significant decrease in body weight and body mass index (BMI) versus controls at 8 weeks (-2.5 +/- 0.7 kg, p < 0.01, and -1.9 +/- 0.6, p < 0.05, respectively). Green tea beverage showed a decreasing trend in LDL-cholesterol and LDL/high-density lipoprotein (HDL) versus controls (p < 0.1). Green tea beverage also significantly decreased MDA and HNE (-0.39 +/- 0.06 mu M, p < 0.0001) versus controls. Plasma free catechins were detectable in both beverage and extract groups versus controls at screen and at 8 weeks, indicating compliance and bioavailability of green tea catechins.
   Conclusions: Green tea beverage consumption (4 cups/d) or extract supplementation (2 capsules/d) for 8 weeks significantly decreased body weight and BMI. Green tea beverage further lowered lipid peroxidation versus age- and gender-matched controls, suggesting the role of green tea flavonoids in improving features of metabolic syndrome in obese patients.
C1 [Basu, Arpita; Sanchez, Karah; Betts, Nancy M.] Oklahoma State Univ, Stillwater, OK 74078 USA.
   [Leyva, Misti J.; Aston, Christopher E.; Lyons, Timothy J.] Univ Oklahoma, Hlth Sci Ctr, Gen Clin Res Ctr, Oklahoma City, OK USA.
   [Wu, Mingyuan; Lyons, Timothy J.] Univ Oklahoma, Hlth Sci Ctr, Harold Hamm Oklahoma Diabet Ctr, Oklahoma City, OK USA.
   [Wu, Mingyuan; Lyons, Timothy J.] Univ Oklahoma, Hlth Sci Ctr, Dept Med Endocrinol, Oklahoma City, OK USA.
C3 Oklahoma State University System; Oklahoma State University -
   Stillwater; University of Oklahoma System; University of Oklahoma Health
   Sciences Center; University of Oklahoma System; University of Oklahoma
   Health Sciences Center; University of Oklahoma System; University of
   Oklahoma Health Sciences Center
RP Basu, A (corresponding author), Oklahoma State Univ, Stillwater, OK 74078 USA.
EM arpita.basu@okstate.edu
OI Lyons, Timothy/0000-0003-2106-1622
FU University of Oklahoma Health Sciences Center [M01-RR14467]; National
   Center for Research Resources; National Institutes of Health; College of
   Human Environmental Sciences, Oklahoma State University
FX The authors wish to thank Kavitha Penugonda for her technical assistance
   in plasma catechin analyses, all OUHSC employees for their participation
   in the study, and the Bionutrition staff at GCRC for administration of
   intervention and patient follow-up. This work was supported in part by
   the University of Oklahoma Health Sciences Center General Clinical
   Research Center grant M01-RR14467, National Center for Research
   Resources, National Institutes of Health. It was also supported by the
   College of Human Environmental Sciences, Oklahoma State University.
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NR 47
TC 255
Z9 268
U1 1
U2 90
PU AMER COLLEGE NUTRITION
PI CLEARWATER
PA 300 SOUTH DUNCAN AVENUE, STE 225, CLEARWATER, FL 33755 USA
SN 0731-5724
J9 J AM COLL NUTR
JI J. Am. Coll. Nutr.
PD FEB
PY 2010
VL 29
IS 1
BP 31
EP 40
DI 10.1080/07315724.2010.10719814
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 626WF
UT WOS:000279997700005
PM 20595643
DA 2025-06-11
ER

PT J
AU Steckling, FM
   Farinha, JB
   Figueiredo, FD
   Dos Santos, DL
   Bresciani, G
   Kretzmann, NA
   Stefanello, ST
   Courtes, AA
   Beck, MD
   Cardoso, MS
   Duarte, MMMF
   Moresco, RN
   Soares, FAA
AF Steckling, Flavia Marie
   Farinha, Juliano Boufleur
   Figueiredo, Felipe da Cunha
   Dos Santos, Daniela Lopes
   Bresciani, Guilherme
   Kretzmann, Nelson Alexandre
   Stefanello, Silvio Terra
   Courtes, Aline Alves
   Beck, Maristela de Oliveira
   Cardoso, Manuela Sangoi
   Medeiros Frescura Duarte, Marta Maria
   Moresco, Rafael Noal
   Antunes Soares, Felix Alexandre
TI High-intensity interval training improves inflammatory and adipokine
   profiles in postmenopausal women with metabolic syndrome
SO ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
LA English
DT Article
DE Metabolic syndrome; obesity; adipokines; mRNA; high-intensity interval
   training
ID BLOOD MONONUCLEAR-CELLS; WEIGHT-LOSS; OXIDATIVE STRESS; GENE-EXPRESSION;
   EXERCISE; ADIPONECTIN; RESISTANCE; CYTOKINE; OBESITY; LEPTIN
AB This study investigate the effects of high-intensity interval training (HIIT) on systemic levels of inflammatory and hormonal markers in postmenopausal women with metabolic syndrome (MS). Fifteen postmenopausal women with MS completed the training on treadmills. Functional, body composition parameters, maximal oxygen uptake (VO(2)max), and lipid profile were assessed before and after HIIT. Serum or plasma levels of cytokines and hormonal markers were measured along the intervention. The analysis of messenger RNA (mRNA) expression of these cytokines was performed in peripheral blood mononuclear cells (PBMC). VO(2)max and some anthropometric parameters were improved after HIIT, while decreased levels of proinflammatory markers and increased levels of interleukin-10 (IL-10) were also found. Adipokines were also modulated after 12 weeks or training. The mRNA expression of the studied genes was unchanged after HIIT. In conclusion, HIIT benefits inflammatory and hormonal axis on serum or plasma samples, without changes on PBMC of postmenopausal MS patients.
C1 [Steckling, Flavia Marie; Farinha, Juliano Boufleur; Figueiredo, Felipe da Cunha; Dos Santos, Daniela Lopes] Univ Fed Santa Maria, Ctr Educ Fis & Desportos, Dept Metodos & Tecn Desportivas, Santa Maria, RS, Brazil.
   [Steckling, Flavia Marie; Stefanello, Silvio Terra; Courtes, Aline Alves; Antunes Soares, Felix Alexandre] Univ Fed Santa Maria, CCNE, Dept Bioquim & Biol Mol, BR-97105900 Santa Maria, RS, Brazil.
   [Farinha, Juliano Boufleur] Univ Fed Rio Grande do Sul, Escola Educ Fis Fisioterapia & Danca, Porto Alegre, RS, Brazil.
   [Bresciani, Guilherme] Pontificia Univ Catolica Valparaiso, Escuela Educ Fis, Grp Invest Rendimiento Fis & Salud IRyS, Valparaiso, Chile.
   [Kretzmann, Nelson Alexandre] Hosp Clin Porto Alegre, Porto Alegre, RS, Brazil.
   [Beck, Maristela de Oliveira] Univ Fed Santa Maria, Dept Posgrad Multiprofiss Ciencias Saude, Ctr Ciencias Saude, Santa Maria, RS, Brazil.
   [Cardoso, Manuela Sangoi; Moresco, Rafael Noal] Univ Fed Santa Maria, Ctr Ciencias SaUde, Dept Anal Clin & Toxicol, Santa Maria, RS, Brazil.
   [Medeiros Frescura Duarte, Marta Maria] Univ Luterana Brasil, Canoas, Brazil.
C3 Universidade Federal de Santa Maria (UFSM); Universidade Federal de
   Santa Maria (UFSM); Universidade Federal do Rio Grande do Sul;
   Pontificia Universidad Catolica de Valparaiso; Hospital de Clinicas de
   Porto Alegre; Universidade Federal de Santa Maria (UFSM); Universidade
   Federal de Santa Maria (UFSM); Universidade Luterana do Brasil
RP Soares, FAA (corresponding author), Univ Fed Santa Maria, CCNE, Dept Bioquim & Biol Mol, BR-97105900 Santa Maria, RS, Brazil.
EM felix@ufsm.br
RI Soares, Félix/AAE-6251-2020; Kretzmann, Nelson/B-3941-2013; Bresciani,
   Guilherme/M-6805-2014; Farinha, Juliano/HDN-8796-2022; dos Santos,
   Daniela/AAU-2310-2021; Moresco, Rafael/K-6118-2017; Stefanello, Silvio
   Terra/I-3106-2014; Soares, Felix/K-7611-2012
OI Moresco, Rafael/0000-0003-3072-5080; Stefanello, Silvio
   Terra/0000-0002-6673-6550; Soares, Felix/0000-0002-6453-7902; Boufleur
   Farinha, Juliano/0000-0003-4589-256X
FU CAPES (Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior);
   CNPq (Conselho Nacional de Desenvolvimento Cientifico e Tecnologico)
FX J.B.F. and S.T.S. received fellowship from CAPES (Coordenacao de
   Aperfeicoamento de Pessoal de Nivel Superior). F.A.A.S. received a
   fellowship from CNPq (Conselho Nacional de Desenvolvimento Cientifico e
   Tecnologico).
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NR 50
TC 23
Z9 24
U1 0
U2 14
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1381-3455
EI 1744-4160
J9 ARCH PHYSIOL BIOCHEM
JI Arch. Physiol. Biochem.
PD JAN 1
PY 2019
VL 125
IS 1
BP 85
EP 91
DI 10.1080/13813455.2018.1437750
PG 7
WC Biochemistry & Molecular Biology; Biophysics; Endocrinology &
   Metabolism; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Endocrinology &
   Metabolism; Physiology
GA HP0ZL
UT WOS:000461395000011
PM 29431478
DA 2025-06-11
ER

PT J
AU Linnville, S
   Hoyt, RE
   Moore, JL
   Segovia, F
   Hain, RE
AF Linnville, Steven
   Hoyt, Robert E.
   Moore, Jeffrey L.
   Segovia, Francine
   Hain, Robert E.
TI Posttraumatic Stress Disorder and Metabolic Syndrome: Retrospective
   Study of Repatriated Prisoners of War
SO MILITARY MEDICINE
LA English
DT Article
ID CARDIOVASCULAR-DISEASE; INSULIN-RESISTANCE; RISK; ASSOCIATION;
   MORTALITY; VETERANS; HEALTH
AB Objective: We conducted a retrospective study of metabolic data for Vietnam-era repatriated prisoners of war (RPWs) and a comparison group to determine if metabolic syndrome (MbS) was more common in those individuals with clinically diagnosed, current or lifetime posttraumatic stress disorder (PTSD) as suggested in a recent report. Methods: The metabolic data of our patients nearest the time of psychiatric evaluation (1998-2004) for PTSD were analyzed using both an analysis of variance and logistic regression. Results: Although we found elevated triglyceride levels (40 mg/dl higher) in RPWs with PTSD who met MbS criteria, overall the prevalence of MbS was the same in RPWs with and without PTSD and comparison group. Moreover, current PTSD symptom severity did not increase the likelihood of MbS. Conclusions: Our results from these repatriates who actively participate in a 37-year medical follow up program do not support the conclusion that MbS occurs more commonly in individuals with current PTSD.
C1 [Linnville, Steven; Hoyt, Robert E.; Moore, Jeffrey L.; Segovia, Francine; Hain, Robert E.] Robert E Mitchell Ctr Prisoner War Studies, Pensacola, FL 32508 USA.
RP Linnville, S (corresponding author), Robert E Mitchell Ctr Prisoner War Studies, 220 Hovey Rd, Pensacola, FL 32508 USA.
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NR 32
TC 13
Z9 15
U1 0
U2 1
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0026-4075
EI 1930-613X
J9 MIL MED
JI Milit. Med.
PD APR
PY 2011
VL 176
IS 4
BP 369
EP 374
DI 10.7205/MILMED-D-10-00367
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 825BO
UT WOS:000295246100005
PM 21539157
OA Bronze
DA 2025-06-11
ER

PT J
AU Wlodarczyk, A
   Cubala, WJ
   Stawicki, M
AF Wlodarczyk, Adam
   Cubala, Wieslaw J.
   Stawicki, Mateusz
TI Ketogenic diet for depression: A potential dietary regimen to maintain
   euthymia
SO PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
LA English
DT Article
DE GABA; Gut-brain axis; Gut microbiome; Ketosis; Major depressive
   disorder; Neurotransmission
ID TREATMENT-RESISTANT DEPRESSION; TRYPTOPHAN CATABOLITE TRYCAT; GUT
   MICROBIOTA; SCHIZOPHRENIA; ANXIETY; GABA; PREVENTION; DISORDERS; ACID
AB Approximately 30% of patients with major depressive disorder (MDD) present resistance to current pharmacological therapies. There is the possibility that an appropriate nutritional regimen can maintain euthymia. Poor dietary pattern and lack of nutritional knowledge are common among today's population; nutrient-rich foods are being replaced by highly processed foods that lead to a higher risk of developing chronic diseases such as metabolic syndrome, hypercholesterolemia, and diabetes. There is growing evidence of the beneficial role of vitamins and dietary supplements for improving symptoms in a range of affective disorders by regulating the gut microbiome, gut-brain axis, and neurotransmitter levels. Reduced GABA neurotransmission is regularly observed in MDD. Moreover, positive allosteric GABA modulators (i.e benzodiazepines) are widely prescribed to alleviate depression symptoms, but their use needs to be limited, as it can lead to addiction. An alternative option may be the adherence to a ketogenic diet, which consists of low-carbohydrate, moderate-protein, and high-fat intake. It is mainly known for its beneficial role in weight-loss, refractory epilepsy treatment, and balancing glucose levels. A ketogenic diet can also increase GABA levels to aid the mechanism of action of monoaminergic drugs. Thus, it could potentially be used in the treatment for affective disorders due to its potential role in GABA/glutamate balance. While more research is needed before this regimen can be regularly recommended to patients, here we discuss evidence that may encourage physicians to prescribe ketogenic diet as an adjuvant for patients receiving psychotherapy and pharmacology.
C1 [Wlodarczyk, Adam; Cubala, Wieslaw J.; Stawicki, Mateusz] Med Univ Gdansk, Fac Med, Dept Psychiat, 7 Dybinki St Build 25, PL-80952 Gdansk, Poland.
C3 Fahrenheit Universities; Medical University Gdansk
RP Wlodarczyk, A (corresponding author), Med Univ Gdansk, Fac Med, Dept Psychiat, 7 Dybinki St Build 25, PL-80952 Gdansk, Poland.
EM aswlodarczyk@gumed.edu.pl; cubala@gumed.edu.pl
RI Cubała, Wiesław/N-6113-2018; Włodarczyk, Adam/AEK-1847-2022
OI Wlodarczyk, Adam/0000-0001-8549-254X
FU Medical University of Gdansk, Poland [02-0039/07/221]
FX This work was supported by grant no. 02-0039/07/221 from the Medical
   University of Gdansk, Poland.
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NR 55
TC 31
Z9 33
U1 2
U2 35
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0278-5846
EI 1878-4216
J9 PROG NEURO-PSYCHOPH
JI Prog. Neuro-Psychopharmacol. Biol. Psychiatry
PD JUL 13
PY 2021
VL 109
AR 110257
DI 10.1016/j.pnpbp.2021.110257
EA JAN 2021
PG 6
WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA SG4XV
UT WOS:000653445500007
PM 33497756
DA 2025-06-11
ER

PT J
AU Kakehashi, A
   Suzuki, S
   Ishii, N
   Okuno, T
   Kuwae, Y
   Fujioka, M
   Gi, M
   Stefanov, V
   Wanibuchi, H
AF Kakehashi, Anna
   Suzuki, Shugo
   Ishii, Naomi
   Okuno, Takahiro
   Kuwae, Yuko
   Fujioka, Masaki
   Gi, Min
   Stefanov, Vasily
   Wanibuchi, Hideki
TI Accumulation of 8-hydroxydeoxyguanosine, L-arginine and Glucose
   Metabolites by Liver Tumor Cells Are the Important Characteristic
   Features of Metabolic Syndrome and Non-Alcoholic
   Steatohepatitis-Associated Hepatocarcinogenesis
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE metabolic syndrome; type 2-diabetes; NASH; HCC; L-arginine; AGR1
ID S-ADENOSYLMETHIONINE; MODEL; HOMOCYSTEINE; DEPRIVATION; EXPRESSION;
   OBESITY; STRESS; GROWTH; TISSUE; MOUSE
AB To uncover mechanisms and explore novel biomarkers of obesity, type 2 diabetes (T2DM) and nonalcoholic steatohepatitis (NASH)-associated hepatocarcinogenesis, cellular and molecular alterations in the liver, and hepatocellular carcinomas (HCCs) were investigated in NASH model 60-week-old Tsumura, Suzuki, Obese Diabetic (TSOD) mice and NASH HCC patients. Markedly elevated lipid deposition, inflammation, fibrosis, and peroxisome proliferation in the liver, preneoplastic lesions, and HCCs of TSOD mice were accompanied by accumulation of polysaccharides in the cellular cytoplasm and nuclei and increase of oxidative DNA damage marker, 8-hydroxydeoxyguanosine (8-OHdG) formation in the liver and altered foci. Metabolomics of TSOD mice HCCs demonstrated significant elevation of the concentration of amino acid L-arginine, phosphocreatine, S-adenosylmethionine/S-adenosylhomocysteine ratio, adenylate, and guanylate energy charges in coordination with tremendous rise of glucose metabolites, mostly fructose 1,6-diphosphate. L-arginine accumulation in HCCs was associated with significant under-expression of arginase 1 (ARG1), suppression of the urea cycle, methionine and putrescine degradation pathways, activation of Ser and Thr kinase Akt AKT, phosphoinositide 3-kinase (PI3K), extracellular signal-regulated kinase 1/2 (ERK1/2) kinases, beta-catenin, mammalian target of rapamycin (mTOR), and cell proliferation. Furthermore, clinicopathological analysis in 20 metabolic syndrome/NASH and 80 HCV-positive HCC patients demonstrated significant correlation of negative ARG1 expression with poor tumor differentiation, higher pathological stage, and significant decrease of survival in metabolic syndrome/NASH-associated HCC patients, thus indicating that ARG1 could become a potential marker for NASH HCC. From these results, formation of oxidative stress and 8-OHdG in the DNA and elevation of glucose metabolites and L-arginine due to ARG1 suppression in mice liver cells are the important characteristics of T2DM/NASH-associated hepatocarcinogenesis, which may take part in activating oxidative stress resistance, synthesis of phosphocreatine, cell signaling, methylation, and proliferation.
C1 [Kakehashi, Anna; Suzuki, Shugo; Ishii, Naomi; Okuno, Takahiro; Fujioka, Masaki; Gi, Min; Wanibuchi, Hideki] Osaka City Univ, Grad Sch Med, Dept Mol Pathol, Abeno Ku, 1-4-3 Asahi Machi, Osaka 5458585, Japan.
   [Kuwae, Yuko] Osaka City Univ, Grad Sch Med, Dept Diagnost Pathol, Abeno Ku, 1-4-3 Asahi Machi, Osaka 5458585, Japan.
   [Stefanov, Vasily] St Petersburg State Univ, Dept Biochem, St Petersburg 199034, Russia.
C3 Osaka Metropolitan University; Osaka Metropolitan University; Saint
   Petersburg State University
RP Kakehashi, A (corresponding author), Osaka City Univ, Grad Sch Med, Dept Mol Pathol, Abeno Ku, 1-4-3 Asahi Machi, Osaka 5458585, Japan.
EM anna@med.osaka-cu.ac.jp; suzuki.shugo@med.osaka-cu.ac.jp;
   m1159070@med.osaka-cu.ac.jp; m2026860@med.osaka-cu.ac.jp;
   kuwaeyu@med.osaka-cu.ac.jp; m2066048@med.osaka-cu.ac.jp;
   mwei@med.osaka-cu.ac.jp; v.stefanov@spbu.ru; wani@med.osaka-cu.ac.jp
RI Kakehashi, Anna/ABF-2986-2020; Fujioka, Masaki/C-7817-2019
OI Kakehashi, Anna/0000-0003-1149-1450; Gi, Min/0000-0003-1642-8127;
   Suzuki, Shugo/0000-0001-8938-9670; Fujioka, Masaki/0000-0003-0048-2874
FU Ministry of Education, Culture, Sports, Science and Technology of Japan
   [17K07177]; Grants-in-Aid for Scientific Research [17K07177] Funding
   Source: KAKEN
FX This research was supported by a Grant-in-Aid for Scientific Research
   from the Ministry of Education, Culture, Sports, Science and Technology
   of Japan (No. 17K07177).
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NR 37
TC 25
Z9 27
U1 2
U2 15
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD OCT
PY 2020
VL 21
IS 20
AR 7746
DI 10.3390/ijms21207746
PG 23
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA OL8ZZ
UT WOS:000585621800001
PM 33092030
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Orsolini, L
   Fiorani, M
   Longo, G
   Manfredi, E
   Cavallo, L
   Marpepa, B
   Bellagamba, S
   Corona, D
   Volpe, U
AF Orsolini, Laura
   Fiorani, Michele
   Longo, Giulio
   Manfredi, Eleonora
   Cavallo, Luciano
   Marpepa, Brodinela
   Bellagamba, Silvia
   Corona, Diana
   Volpe, Umberto
TI Fasting insulinemia as biomarker of illness relapse in patients with
   severe mental illness?
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE Bipolar Disorder (BD); Insulin; Major Depression (MD); Relapse;
   Schizophrenia; Severe mental illness (SMI)
ID HOMEOSTASIS MODEL ASSESSMENT; MAJOR DEPRESSIVE DISORDER; METABOLIC
   SYNDROME; BIPOLAR DISORDER; RESISTANCE; PREVALENCE; SCHIZOPHRENIA;
   MECHANISMS; PEOPLE; ASSOCIATION
AB Severe Mental Illness (SMI) is often associated with metabolic alteration and/or metabolic syndrome, which may determine an increased mortality due to a further increased cardiovascular risk. The relationship with metabolic syndrome is often bidirectional, resulting in a pathoplastic effect of these dysmetabolisms. Among the several hormones involved, insulin appears to play a key role, albeit not entirely clear. The aim of our real-world crosssectional observational study is to investigate a set of metabolic biomarkers of illness relapse/recurrence/onset in a cohort of 310 adult SMI inpatients consecutively admitted to the Psychiatry Clinic of the Azienda Ospedaliero Universitaria of Marche, in Ancona (Italy), between February 2021 and February 2024. According to the stepwise multivariate regression model, a higher number of acute episodes per year was positively predicted by the age of illness onset, the lifetime number of suicidal attempts and fasting insulinemia and negatively by the participant's age. A second stepwise multivariate regression model using only the metabolic characteristics as independent variables, found that a higher number of acute episodes per year was predicted positively by the fasting insulinemia and red blood cells and negatively by the abdominal circumference. Overall, our findings could provide practical implications for the treatment and management of SMI patients, emphasizing the importance of monitoring and managing metabolic factors, particularly insulinemia, metabolic syndrome and insulin resistance. Finally, insulinemia could potentially act as metabolic biomarker of illness relapse, though more larger and longitudinal studies should be carried out to confirm these results.
C1 [Orsolini, Laura; Fiorani, Michele; Longo, Giulio; Manfredi, Eleonora; Cavallo, Luciano; Marpepa, Brodinela; Bellagamba, Silvia; Corona, Diana; Volpe, Umberto] Polytech Univ Marche, Dept Clin Neurosci, Unit Clin Psychiat, DIMSC, Via Tronto 10 A, I-60126 Ancona, Italy.
C3 Marche Polytechnic University
RP Orsolini, L (corresponding author), Polytech Univ Marche, Sch Med, Dept Neurosci, Unit Clin Psychiat,V, Via Tronto 10, I-60126 Ancona, Italy.
EM l.orsolini@staff.univpm.it
RI Volpe, Umberto/IVH-1655-2023; Longo, Giulio/IWD-7764-2023
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NR 49
TC 0
Z9 0
U1 1
U2 1
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
EI 1873-3360
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD DEC
PY 2024
VL 170
AR 107171
DI 10.1016/j.psyneuen.2024.107171
EA SEP 2024
PG 11
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA E9W2V
UT WOS:001306425700001
PM 39232276
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Naldi, L
   Mercuri, SR
AF Naldi, Luigi
   Mercuri, Santo Raffaele
TI Epidemiology of comorbidities in psoriasis
SO DERMATOLOGIC THERAPY
LA English
DT Article
DE arthritis; cancer; cardiovascular disease; comorbidities; epidemiology;
   psoriasis; risk factors
ID POPULATION-BASED COHORT; BODY-MASS INDEX; RHEUMATOID-ARTHRITIS;
   PALMOPLANTAR PUSTULOSIS; METABOLIC SYNDROME; VASCULAR-DISEASES;
   CELIAC-DISEASE; CANCER-RISK; MORTALITY; OBESITY
AB Epidemiological studies have shown that, in patients with psoriasis, associated disorders may occur more frequently than expected. Such comorbidities include, among others, psoriatic arthritis, inflammatory bowel disease, obesity, diabetes, cardiovascular disease, several cancer types, and depression. Comorbidities often become clinically manifest years after onset of psoriasis and tend to be more frequently seen in severe disease.
C1 [Naldi, Luigi] Presidio Osped liero Matteo Rota, Fdn Ric Osped Maggiore, Ctr Studi GISED, I-24122 Bergamo, Italy.
   [Naldi, Luigi] Osped Riuniti Bergamo, Unita Dermatol, I-24100 Bergamo, Italy.
   [Mercuri, Santo Raffaele] Univ Vita Salute, Unita Dermatol, Ist Ricovero & Cura Carattere Sci San Raffaele, Milan, Italy.
C3 Ospedali Riuniti di Bergamo; Vita-Salute San Raffaele University
RP Naldi, L (corresponding author), Presidio Osped liero Matteo Rota, Fdn Ric Osped Maggiore, Ctr Studi GISED, Via Garibaldi 13-15, I-24122 Bergamo, Italy.
EM luigi.naldi@gised.it
RI Mercuri, Santo/AAN-3776-2020; Naldi, Luigi/K-6343-2016
OI Naldi, Luigi/0000-0002-3160-2835; Mercuri, Santo
   Raffaele/0000-0002-9175-4574
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NR 37
TC 77
Z9 83
U1 1
U2 10
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1396-0296
EI 1529-8019
J9 DERMATOL THER
JI Dermatol. Ther.
PD MAR-APR
PY 2010
VL 23
IS 2
BP 114
EP 118
DI 10.1111/j.1529-8019.2010.01304.x
PG 5
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 574RT
UT WOS:000276011200003
PM 20415817
OA gold
DA 2025-06-11
ER

PT J
AU Chaix, A
   Lin, T
   Le, HD
   Chang, MW
   Panda, S
AF Chaix, Amandine
   Lin, Terry
   Le, Hiep D.
   Chang, Max W.
   Panda, Satchidananda
TI Time-Restricted Feeding Prevents Obesity and Metabolic Syndrome in Mice
   Lacking a Circadian Clock
SO CELL METABOLISM
LA English
DT Article
ID REV-ERB-ALPHA; LIVER; PHOSPHORYLATION; OSCILLATIONS; MECHANISMS;
   RHYTHMS; CRY2
AB Increased susceptibility of circadian clock mutant mice to metabolic diseases has led to the idea that a molecular clock is necessary for metabolic homeostasis. However, these mice often lack a normal feeding-fasting cycle. We tested whether time-restricted feeding (TRF) could prevent obesity and metabolic syndrome in whole-body Cry1; Cry2 and in liver-specific Bmal1 and Rev-erb alpha/beta knockout mice. When provided access to food ad libitum, these mice rapidly gained weight and showed genotype-specific metabolic defects. However, when fed the same diet under TRF (food access restricted to 10 hr during the dark phase) they were protected from excessive weight gain and metabolic diseases. Transcriptome and metabolome analyses showed that TRF reduced the accumulation of hepatic lipids and enhanced cellular defenses against metabolic stress. These results suggest that the circadian clock maintains metabolic homeostasis by sustaining daily rhythms in feeding and fasting and by maintaining balance between nutrient and cellular stress responses.
C1 [Chaix, Amandine; Lin, Terry; Le, Hiep D.; Panda, Satchidananda] Salk Inst Biol Studies, 10010 N Torrey Pines Rd, La Jolla, CA 92037 USA.
   [Chang, Max W.] Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA.
C3 Salk Institute; University of California System; University of
   California San Diego
RP Panda, S (corresponding author), Salk Inst Biol Studies, 10010 N Torrey Pines Rd, La Jolla, CA 92037 USA.
EM satchin@salk.edu
RI , Le Dai Hiep/AAE-1029-2019
OI Chaix, Amandine/0000-0001-7007-197X; Lin, Terry/0000-0002-1766-6066;
   Chang, Max/0000-0002-4526-489X
FU American Federation for Aging Research (AFAR) [M14322]; NIH [DK115214,
   P30 CA014195, P30 EY019005, P50 GM085764, R24 DK080506]; Glenn Center
   for Aging, Leona M. and Harry B. Helmsley Charitable Trust
   [2012-PG-MED002]; American Diabetes Association [7-12-MN-64]; American
   Heart Association Career Development Award [18CDA34110292]; Philippe
   Foundation Inc., New York; Salk Institute; American Heart Association
   (AHA) [18CDA34110292] Funding Source: American Heart Association (AHA)
FX This work was partially supported by American Federation for Aging
   Research (AFAR) grant M14322, and NIH grant DK115214 to S.P. and funding
   to research cores through NIH P30 CA014195, P30 EY019005, P50 GM085764,
   R24 DK080506, and the Glenn Center for Aging, Leona M. and Harry B.
   Helmsley Charitable Trust's grant no. 2012-PG-MED002. A.C. was supported
   by a mentor-based postdoctoral fellowship from the American Diabetes
   Association (7-12-MN-64), American Heart Association Career Development
   Award (18CDA34110292), and has received support from the Philippe
   Foundation Inc., New York, and a Women in Science Award from the Salk
   Institute. The authors would like to thank Phuong Miu and Benjamin
   Shifflett for technical assistance, and David O'Keefe for editing the
   manuscript.
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NR 58
TC 452
Z9 499
U1 12
U2 237
PU CELL PRESS
PI CAMBRIDGE
PA 50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA
SN 1550-4131
EI 1932-7420
J9 CELL METAB
JI Cell Metab.
PD FEB 5
PY 2019
VL 29
IS 2
BP 303
EP +
DI 10.1016/j.cmet.2018.08.004
PG 21
WC Cell Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Endocrinology & Metabolism
GA HK2AA
UT WOS:000457708100011
PM 30174302
OA Green Accepted, Bronze
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Majanovic, SK
   Ruzic, A
   Bulian, AP
   Licul, V
   Orlic, ZC
   Stimac, D
AF Majanovic, Sanja Klobucar
   Ruzic, Alen
   Bulian, Alessandra Pokrajac
   Licul, Vanja
   Orlic, Zeljka Crncevic
   Stimac, Davor
TI Comparative Study of Intragastric Balloon and Cognitive-Behavioral
   Approach for Non-Morbid Obesity
SO HEPATO-GASTROENTEROLOGY
LA English
DT Article
DE Intragastric balloon; Cognitive-behavioral treatment; Obesity; Weight
   loss; Metabolic syndrome
ID INSULIN-RESISTANCE; METABOLIC SYNDROME; LIVER-DISEASE; FOLLOW-UP;
   AMINOTRANSFERASE
AB Background/Aims: Intragastric balloon (IGB) and,Cognitive-behavioral therapy (CBT) are possible options for weight reduction. The aim of our study was to compare their effectivness in inducing weight loss and metabolic changes accompanying weight loss in non-morbidly obese patients. Methodology: Subjects were required to be between 18 and 55 years old and to have a BMI between 30 and 45 to be eligible. Exclusion criteria, besides those for IGB placement, were the presence of diabetes, depression, binge-eating disorder and the use of medications that affect body weight. Anthropometric, biochemical and blood pressure measurements were performed at baseline and after 6 months. A total of 114 subjects were recruited to the study and assigned to IGB (n = 60) or CBT group (n = 54). All patients completed the study. Results: After 6 months, patients treated with IGB lost significantly (P <0.01) more weight (%EWL = 44.6 +/- 23.9) than patients who participate in CBT (%EWL = 24.3 +/- 16.0). In IGB group 75% of patients achieved >= 10% loss of initial weight, and 42.6% of patients in CBT group respectively. A significant improvement in all indices of metabolic syndrome except HDL cholesterol was seen in both treatment groups but much more in subjects treated with IGB. Conclusions: Our results confirmed that intragastric balloon is useful: method for promoting weight loss. Due to improvement of metabolic parameters and substantial benefit on liver function, obese people with metabolic syndrome appear to be the best candidates for IGB placement. Combining intragastric balloon treatment with cognitive-behavioral approach might prove valuable for even greater weight loss.
C1 [Majanovic, Sanja Klobucar; Orlic, Zeljka Crncevic] Clin Hosp Ctr Rijeka, Div Endocrinol, Dept Internal Med, Rijeka, Croatia.
   [Ruzic, Alen] Clin Hosp Ctr Rijeka, Div Cardiol, Dept Internal Med, Rijeka, Croatia.
   [Bulian, Alessandra Pokrajac] Univ Rijeka, Fac Phylosophy, Dept Psychol, Rijeka, Croatia.
   [Licul, Vanja; Stimac, Davor] Clin Hosp Ctr Rijeka, Div Gastroenterol, Dept Internal Med, Rijeka, Croatia.
C3 University of Rijeka; University of Rijeka; University of Rijeka;
   University of Rijeka
RP Majanovic, SK (corresponding author), Univ Hosp Rijeka, Dept Internal Med, Div Endocrinol, Kresimirova 42, Rijeka 51000, Croatia.
EM sanja.klobucar@ri.t-com.hr
RI Štimac, Davor/ABF-7086-2020; Klobucar, Sanja/P-5969-2018;
   Pokrajac-Bulian, Alessandra/Q-9304-2018; Ruzic, Alen/N-2117-2018; Licul,
   Vanja/S-2800-2018; Stimac, Davor/S-7420-2018
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   Ruzic, Alen/0000-0001-5031-2975; Licul, Vanja/0000-0002-4787-7526;
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NR 30
TC 6
Z9 6
U1 0
U2 7
PU H G E UPDATE MEDICAL PUBLISHING S A
PI ATHENS
PA PO BOX 17257, ATHENS GR-10024, GREECE
SN 0172-6390
J9 HEPATO-GASTROENTEROL
JI Hepato-Gastroenterol.
PD JUN
PY 2014
VL 61
IS 132
BP 937
EP 941
DI 10.5754/hge14146
PG 5
WC Gastroenterology & Hepatology; Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology; Surgery
GA CV0CB
UT WOS:000363913800010
PM 26158145
DA 2025-06-11
ER

PT J
AU Kim, S
   Subramanian, V
   Abdel-Latif, A
   Lee, SD
AF Kim, Seonwook
   Subramanian, Venkateswaran
   Abdel-Latif, Ahmed
   Lee, Sangderk
TI Role of Heparin-Binding Epidermal Growth Factor-Like Growth Factor in
   Oxidative Stress-Associated Metabolic Diseases
SO METABOLIC SYNDROME AND RELATED DISORDERS
LA English
DT Article
DE HB-EGF; endothelial cells; metabolic syndrome; atherosclerosis; NAFLD
ID LOW-DENSITY-LIPOPROTEIN; FACTOR RECEPTOR TRANSACTIVATION; SINUSOIDAL
   ENDOTHELIAL-CELLS; EGF MONOCLONAL-ANTIBODY; FACTOR MESSENGER-RNA;
   HB-EGF; ANGIOTENSIN-II; BONE-MARROW; IN-VIVO; INSULIN-RESISTANCE
AB Heparin-binding EGF-like growth factor (HB-EGF) is an EGF family member that interacts with epidermal growth factor receptor (EGFR) and ERBB4. Since HB-EGF was first identified as a novel growth factor secreted from a human macrophage cell line, numerous pathological and physiological functions related to cell proliferation, migration, and inflammation have been reported. Notably, the expression of HB-EGF is sensitively upregulated by oxidative stress in the endothelial cells and functions for auto- and paracrine-EGFR signaling. Overnutrition and obesity cause elevation of HB-EGF expression and EGFR signaling in the hepatic and vascular systems. Modulations of HB-EGF signaling showed a series of protections against phenotypes related to metabolic syndrome and advanced metabolic diseases, suggesting HB-EGF as a potential target against metabolic diseases.
C1 [Kim, Seonwook; Subramanian, Venkateswaran; Abdel-Latif, Ahmed; Lee, Sangderk] Univ Kentucky, Coll Med, Saha Cardiovasc Res Ctr, 741 South Limestone,BBSRB B251, Lexington, KY 40536 USA.
   [Subramanian, Venkateswaran] Univ Kentucky, Coll Med, Dept Physiol, Lexington, KY USA.
   [Abdel-Latif, Ahmed] Univ Kentucky, Coll Med, Dept Med Cardiol, Lexington, KY USA.
   [Lee, Sangderk] Univ Kentucky, Coll Med, Dept Pharmacol & Nutr Sci, Lexington, KY USA.
C3 University of Kentucky; University of Kentucky; University of Kentucky;
   University of Kentucky
RP Lee, SD (corresponding author), Univ Kentucky, Coll Med, Saha Cardiovasc Res Ctr, 741 South Limestone,BBSRB B251, Lexington, KY 40536 USA.
EM sangderk.lee@uky.edu
RI Latif, Ahmed/GRN-8757-2022
OI Kim, Seonwook/0009-0006-5180-1651
FU National Institutes of Health [K99/R00 HL105577]; American Heart
   Association [17GRNT33700302]; American Heart Association (AHA)
   [17GRNT33700302] Funding Source: American Heart Association (AHA)
FX This study was supported by the National Institutes of Health K99/R00
   HL105577 (S.L.) and the American Heart Association 17GRNT33700302
   (S.L.).
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NR 146
TC 17
Z9 18
U1 0
U2 4
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-4196
EI 1557-8518
J9 METAB SYNDR RELAT D
JI Metab. Syndr. Relat. Disord.
PD MAY 1
PY 2020
VL 18
IS 4
BP 186
EP 196
DI 10.1089/met.2019.0120
EA FEB 2020
PG 11
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA LJ2YG
UT WOS:000515317400001
PM 32077785
OA Green Published
DA 2025-06-11
ER

PT J
AU Gálvez, I
   Martín-Cordero, L
   Hinchado, MD
   Ortega, E
AF Galvez, Isabel
   Martin-Cordero, Leticia
   Dolores Hinchado, Maria
   Ortega, Eduardo
TI β2 Adrenergic Regulation of the Phagocytic and Microbicide Capacity of
   Circulating Monocytes: Influence of Obesity and Exercise
SO NUTRIENTS
LA English
DT Article
DE beta 2 adrenergic receptors; terbutaline; obesity; exercise; monocytes;
   phagocytosis; microbicide activity; toll-like receptors; TLR4; TLR2
ID METABOLIC SYNDROME-X; PERITONEAL-MACROPHAGES; ADIPOSE-TISSUE;
   INFLAMMATION; STRESS; RECEPTORS; MODULATION; GAMMA; NOREPINEPHRINE;
   NORADRENALINE
AB Obese individuals present anomalous immune/inflammatory responses with dysregulations in neuroendocrine responses and immune/stress feedback mechanisms. In this context, exercise and beta 2 adrenergic activation present monocyte-mediated anti-inflammatory effects that are modulated by obesity. However, these anti-inflammatory effects could immunocompromise the monocyte-mediated innate response against a pathogen challenge. Thus, the objective of this work was to evaluate the effect of obesity, and exercise in this condition, on the beta 2 adrenergic regulation of the phagocytic and microbicide capacity of circulating monocytes. C57BL/6J mice were allocated to different sedentary or exercised, lean or obese groups. Obese mice showed a lower monocyte-mediated innate response than that of lean mice. Globally, selective beta 2 adrenergic receptor agonist terbutaline decreased the innate response of monocytes from lean and obese sedentary animals, whereas exercise stimulated it. Exercise modulates beta 2 adrenergic regulation of the innate response in lean and obese animals, with a global stimulatory or neutral effect, thus abolishing the inhibitory effect of terbutaline occurring in sedentary animals. These effects cannot be explained only by changes in the surface expression of toll-like receptors. Therefore, in general, terbutaline does not hinder the effects of regular exercise, but regular exercise does abolish the effects of terbutaline in sedentary individuals.
C1 [Galvez, Isabel] Univ Extremadura, Fac Med, Dept Enfermeria, Grp Invest Inmunofisiol, Badajoz 06071, Spain.
   [Galvez, Isabel; Martin-Cordero, Leticia; Dolores Hinchado, Maria; Ortega, Eduardo] Inst Univ Invest Biosanitaria Extremadura INUBE, Badajoz 06071, Spain.
   [Martin-Cordero, Leticia] Univ Extremadura, Ctr Univ Plasencia, Dept Enfermeria, Grp Invest Inmunofisiol, Plasencia 10600, Spain.
   [Dolores Hinchado, Maria; Ortega, Eduardo] Univ Extremadura, Fac Ciencias, Dept Fisiol, Grp Invest Inmunofisiol, Badajoz 06071, Spain.
C3 Universidad de Extremadura; Universidad de Extremadura; Universidad de
   Extremadura
RP Ortega, E (corresponding author), Inst Univ Invest Biosanitaria Extremadura INUBE, Badajoz 06071, Spain.; Ortega, E (corresponding author), Univ Extremadura, Fac Ciencias, Dept Fisiol, Grp Invest Inmunofisiol, Badajoz 06071, Spain.
EM igalvez@unex.es; leticiamartin@unex.es; mhinsan@unex.es; orincon@unex.es
RI Martín-Cordero, Leticia/H-9711-2015; Galvez, Isabel/LFS-2823-2024;
   Ortega, Eduardo/GXN-2560-2022; Ortega, Eduardo/H-9891-2016
OI HINCHADO SANCHEZ-MORO, MARIA DOLORES/0000-0002-9709-4714; Galvez,
   Isabel/0000-0002-4294-4507; Ortega, Eduardo/0000-0002-7007-7615
FU Ministerio de Ciencia, Innovacion, y Universidades, Spain
   [DEP2015-66093-R]; Gobierno de Extremadura-Fondo Europeo de Desarrollo
   Regional, Spain [GR18009, IB18011]; 'Formacion del Profesorado
   Universitario (FPU)' pre-doctoral contract from the Ministerio de
   Ciencia, Innovacion y Universidades, Spain [FPU15/02395]
FX This work was partially supported by the Ministerio de Ciencia,
   Innovacion, y Universidades, Spain (DEP2015-66093-R); and the Gobierno
   de Extremadura-Fondo Europeo de Desarrollo Regional, Spain (GR18009;
   IB18011). I.G. is recipient of a `Formacion del Profesorado
   Universitario (FPU)' pre-doctoral contract under grant FPU15/02395 from
   the Ministerio de Ciencia, Innovacion y Universidades, Spain. Funding
   sources had no role in the study design, collection, analysis, and
   interpretation of the data or the decision to submit the manuscript for
   publication.
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NR 64
TC 6
Z9 6
U1 0
U2 2
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD MAY
PY 2020
VL 12
IS 5
AR 1438
DI 10.3390/nu12051438
PG 17
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA MB0AV
UT WOS:000542272700244
PM 32429330
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Levene, AP
   Goldin, RD
AF Levene, Adam P.
   Goldin, Robert D.
TI The epidemiology, pathogenesis and histopathology of fatty liver disease
SO HISTOPATHOLOGY
LA English
DT Review
DE alcoholic liver disease; histopathology; insulin resistance; liver
   biopsy; metabolic syndrome; non-alcoholic fatty liver disease;
   non-alcoholic steatohepatitis; steatosis
ID NECROSIS-FACTOR-ALPHA; NONALCOHOLIC STEATOHEPATITIS; INSULIN-RESISTANCE;
   HEPATOCELLULAR-CARCINOMA; HEPATIC STEATOSIS; UNITED-STATES;
   LIPID-PEROXIDATION; OXIDATIVE STRESS; NATURAL-HISTORY; CHRONIC ETHANOL
AB Levene A P & Goldin R D ?(2012) Histopathology similar to 61, 141152 The epidemiology, pathogenesis and histopathology of fatty liver disease Fatty liver disease includes non-alcoholic fatty liver disease (NAFLD) and alcoholic liver disease (ALD), each of which is increasing in prevalence. Each represents a histological spectrum that extends from isolated steatosis to steatohepatitis and cirrhosis. NAFLD is associated with obesity, diabetes, and insulin resistance, and is considered to be the liver manifestation of the metabolic syndrome. The pathogenesis of NAFLD and ALD involves cytokines, adipokines, oxidative stress, and apoptosis. Histopathology is the gold standard for assessing the severity of liver damage in NAFLD and ALD. We have reviewed the literature, and described and compared the epidemiology, natural disease history, pathogenesis and histopathology of NAFLD and ALD.
C1 [Levene, Adam P.; Goldin, Robert D.] St Marys Hosp, Imperial Coll Fac Med, Dept Histopathol, London W2 1NY, England.
C3 Imperial College London
RP Goldin, RD (corresponding author), St Marys Hosp, Imperial Coll Fac Med, Dept Histopathol, Praed St, London W2 1NY, England.
EM r.goldin@imperial.ac.uk
OI Goldin, Robert/0000-0001-5184-4519
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NR 102
TC 138
Z9 155
U1 0
U2 54
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0309-0167
EI 1365-2559
J9 HISTOPATHOLOGY
JI Histopathology
PD AUG
PY 2012
VL 61
IS 2
BP 141
EP 152
DI 10.1111/j.1365-2559.2011.04145.x
PG 12
WC Cell Biology; Pathology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Pathology
GA 981II
UT WOS:000306959900001
PM 22372457
DA 2025-06-11
ER

PT J
AU Jin, XJ
   Moskophidis, D
   Mivechi, NF
AF Jin, Xiongjie
   Moskophidis, Demetrius
   Mivechi, Nahid F.
TI Heat Shock Transcription Factor 1 Is a Key Determinant of HCC
   Development by Regulating Hepatic Steatosis and Metabolic Syndrome
SO CELL METABOLISM
LA English
DT Article
ID HEPATOCELLULAR-CARCINOMA; STRESS; TARGET; MTOR; PHOSPHORYLATION;
   STEATOHEPATITIS; INFLAMMATION; IMMUNITY; THERAPY; AMPK
AB Hepatocellular carcinoma (HCC) occurrence and progression are linked tightly to progressive hepatic metabolic syndrome associated with insulin resistance, hepatic steatosis, and chronic inflammation. Heat shock transcription factor 1 (HSF1), a major transactivator of stress proteins, increases survival by protecting cells against environmental stressors. It has been implicated in the pathogenesis of cancer, but specific mechanisms by which HSF1 supports cancer development remain elusive. We propose a pathogenic mechanism whereby HSF1 activation promotes growth of premalignant cells and HCC development by stimulating lipid biosynthesis and perpetuating chronic hepatic metabolic disease induced by carcinogens. Our work shows that inactivation of HSF1 impairs cancer progression, mitigating adverse effects of carcinogens on hepatic metabolism by enhancing insulin sensitivity and sensitizing activation of AMP-activated protein kinase (AMPK), an important regulator of energy homeostasis and inhibitor of lipid synthesis. HSF1 is a potential target for the control of hepatic steatosis, hepatic insulin resistance, and HCC development.
C1 [Jin, Xiongjie; Moskophidis, Demetrius; Mivechi, Nahid F.] Georgia Hlth Sci Univ, Ctr Mol Chaperone Radiobiol & Canc Virol, Augusta, GA 30912 USA.
   [Jin, Xiongjie; Moskophidis, Demetrius; Mivechi, Nahid F.] GHSU Canc Ctr, Augusta, GA 30912 USA.
   [Jin, Xiongjie; Mivechi, Nahid F.] Charlie Norwood VA Med Ctr, Augusta, GA 30904 USA.
C3 University System of Georgia; Augusta University; US Department of
   Veterans Affairs; Veterans Health Administration (VHA); Charlie Norwood
   VA Medical Center
RP Moskophidis, D (corresponding author), Georgia Hlth Sci Univ, Ctr Mol Chaperone Radiobiol & Canc Virol, 1410 Laney Walker Blvd,CN-3141, Augusta, GA 30912 USA.
EM dmoskophidis@georgiahealth.edu; nmivechi@georgiahealth.edu
FU National Institutes of Health [CA062130, CA132640, CA121951]
FX The research was supported by National Institutes of Health grants
   CA062130 and CA132640 (N.F.M.) and CA121951 (D.M.).
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NR 43
TC 114
Z9 137
U1 1
U2 14
PU CELL PRESS
PI CAMBRIDGE
PA 50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA
SN 1550-4131
EI 1932-7420
J9 CELL METAB
JI Cell Metab.
PD JUL 6
PY 2011
VL 14
IS 1
BP 91
EP 103
DI 10.1016/j.cmet.2011.03.025
PG 13
WC Cell Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Endocrinology & Metabolism
GA 790JB
UT WOS:000292583200012
PM 21723507
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Ekeuku, SO
   Pang, KL
   Chin, KY
AF Ekeuku, Sophia Ogechi
   Pang, Kok-Lun
   Chin, Kok-Yong
TI Palmatine as an Agent Against Metabolic Syndrome and Its Related
   Complications: A Review
SO DRUG DESIGN DEVELOPMENT AND THERAPY
LA English
DT Review
DE anti-inflammation; antioxidant; myocardial reperfusion injury; obesity;
   osteoporosis; osteoarthritis
ID OXIDATIVE STRESS; ADIPOSE-TISSUE; ALKALOID PALMATINE; RHIZOMA COPTIDIS;
   P-GLYCOPROTEIN; BONE HEALTH; IN-VIVO; ACTIVATION; EXPRESSION; OBESITY
AB Palmatine is a naturally occurring isoquinoline alkaloid with various pharmacological properties. Given its antioxidant and anti-inflammatory properties, palmatine may be able to impede the effects of metabolic syndrome (MetS) and its related diseases triggered by inflammation and oxidative stress. This review summarises the existing literature about the effects of palmatine supplementation on MetS and its complications. The evidence shows that palmatine could protect against MetS, and cardiovascular diseases, osteoporosis and osteoarthritis, which might be associated with MetS. These protective effects are mediated by the antioxidant and anti-inflammatory properties of palmatine. Although preclinical experiments have demonstrated the efficacy of palmatine against MetS and its related diseases, no human clinical trials have been performed to validate these effects. This research gap should be bridged to validate the efficacy and safety of palmatine supplementation in protecting humans against MetS and its related diseases.
C1 [Ekeuku, Sophia Ogechi; Pang, Kok-Lun; Chin, Kok-Yong] Univ Kebangsaan Malaysia, Fac Med, Dept Pharmacol, Jalan Yaacob Latif, Kuala Lumpur 56000, Malaysia.
   [Chin, Kok-Yong] Shanghai Jiao Tong Univ, State Key Lab Oncogenes & Related Genes, Renji Med X Clin Stem Cell Res Ctr, Sch Med,Ren Ji Hosp,Dept Urol, Shanghai, Peoples R China.
C3 Universiti Kebangsaan Malaysia; Shanghai Jiao Tong University
RP Chin, KY (corresponding author), Univ Kebangsaan Malaysia, Fac Med, Dept Pharmacol, Jalan Yaacob Latif, Kuala Lumpur 56000, Malaysia.
EM chinkokyong@ppukm.ukm.edu.my
RI Ekeuku, Sophia/ABI-7123-2020; Pang, Kok/W-2157-2019; Chin,
   Kok-Yong/B-6309-2015
FU Universiti Kebangsaan Malaysia [GUP-2020-021]; Faculty of Medicine,
   Universiti Kebangsaan Malaysia
FX We thank Universiti Kebangsaan Malaysia for funding the researchers
   through grant GUP-2020-021. Sophia Ogechi Ekeuku is a postdoctoral
   researcher funded by Faculty of Medicine, Universiti Kebangsaan Malaysia
   through FPR-1.
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NR 97
TC 32
Z9 35
U1 1
U2 20
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1177-8881
J9 DRUG DES DEV THER
JI Drug Des. Dev. Ther.
PY 2020
VL 14
BP 4963
EP 4974
DI 10.2147/DDDT.S280520
PG 12
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA OX9WF
UT WOS:000593905600001
PM 33235437
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Singer, MA
   Vernino, SA
   Wolfe, GI
AF Singer, Mike A.
   Vernino, Steven A.
   Wolfe, Gil I.
TI Idiopathic neuropathy: new paradigms, new promise
SO JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM
LA English
DT Article
DE chronic idiopathic axonal polyneuropathy; cryptogenic neuropathy;
   cryptogenic sensory polyneuropathy; idiopathic neuropathy; metabolic
   syndrome; obstructive sleep apnea
ID IMPAIRED GLUCOSE-TOLERANCE; PAINFUL SENSORY NEUROPATHY; SMALL FIBER
   NEUROPATHY; OXIDATIVE STRESS; AXONAL POLYNEUROPATHY; PERIPHERAL
   NEUROPATHY; CRYPTOGENIC POLYNEUROPATHY; DIABETIC-NEUROPATHY; METABOLIC
   SYNDROME; UNDETERMINED CAUSE
AB Idiopathic neuropathy, now designated as chronic idiopathic axonal polyneuropathy (CIAP), is a major public health problem in the United States. The disorder affects an estimated 58 million Americans, comprising about one-third of patients with neuropathy, based on data from referral centers. Typically, patients develop symptoms in the sixth decade or older. The onset is insidious, with numbness, paresthesias, and pain appearing over months to years. Although strength is generally preserved, the sensory loss and pain can be disabling. The clinical approach to this condition has evolved in important ways over the years, enabling improved diagnosis and characterization of this population. Current work has focused on identifying modifiable risk factors that may be associated with idiopathic neuropathy. The results may suggest that an underlying mechanism such as oxidative stress contributes to the development of CIAP.
C1 [Singer, Mike A.; Vernino, Steven A.] Univ Texas SW Med Ctr Dallas, Dept Neurol & Neurotherapeut, Dallas, TX 75390 USA.
   [Wolfe, Gil I.] Buffalo Gen Hosp, Dept Neurol, Buffalo, NY 14203 USA.
C3 University of Texas System; University of Texas Southwestern Medical
   Center Dallas; Buffalo General Medical Center
RP Singer, MA (corresponding author), Univ Texas SW Med Ctr Dallas, Dept Neurol & Neurotherapeut, MC 8897,5323 Harry Hines Blvd, Dallas, TX 75390 USA.
EM mike.singer@utsouthwestern.edu
RI Wolfe, Gil/AAO-2786-2020; Vernino, Steven/AAD-5181-2020
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NR 48
TC 40
Z9 42
U1 0
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1085-9489
EI 1529-8027
J9 J PERIPHER NERV SYST
JI J. Peripher. Nerv. Syst.
PD MAY
PY 2012
VL 17
SU 2
SI SI
BP 43
EP 49
DI 10.1111/j.1529-8027.2012.00395.x
PG 7
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 934JU
UT WOS:000303441200009
PM 22548623
OA Bronze
DA 2025-06-11
ER

PT J
AU Wang, B
   Jiang, CQ
   Yu, PP
   Nie, Z
   Wang, N
   Zhang, X
AF Wang, Bo
   Jiang, Chunqi
   Yu, Pingping
   Nie, Zhen
   Wang, Ning
   Zhang, Xin
TI Curvilinear relationship between life's crucial 9 and metabolic syndrome
   in US adults: a cross-sectional study
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Article
DE life's crucial 9; metabolic syndrome; curvilinear; NHANES;
   cross-sectional study
ID CIGARETTE-SMOKING; DEPRESSION; IMPACT
AB Background Metabolic Syndrome (MetS) is closely linked to cardiovascular disease. However, no studies have examined the relationship between Life's Crucial 9 (LC9) and MetS. Our goal is to investigate the potential association between LC9 and MetS.Methods We employed a weighted multivariate logistic regression model to evaluate the relationship between LC9, health behavior score, health factors score, and MetS. To assess the robustness of this association, we conducted sensitivity analyses. Furthermore, we utilized smooth curve fitting to investigate the potential curvilinear relationships between LC9, health behavior score, health factors score, and MetS. To pinpoint inflection points, we integrated recursive partitioning algorithms with a two-stage linear regression model. Additionally, we performed stratified analyses to explore heterogeneity across different population subgroups.Results Our study included a total of 28,555 participants. In the regression model that accounted for all covariates, the OR for LC9 and MetS was 0.941 (0.939, 0.944), indicating a significant negative correlation between the two. Smooth curve analysis confirmed a curvilinear relationship between LC9 and MetS, with an inflection point at 70.56. The negative correlation was evident both before and after the inflection point, with a more pronounced effect after the inflection point. Subgroup analyses of Health behavior score and Health factors score, as well as stratified analyses by age, sex, and BMI, showed that all groups exhibited curvilinear relationships consistent with the overall pattern.Conclusion The curvilinear relationship between LC9 scores and metabolic syndrome indicates that higher LC9 scores act as a protective factor against MetS.
C1 [Wang, Bo] Cent Hosp Jinan City, Jinan, Shandong, Peoples R China.
   [Jiang, Chunqi; Zhang, Xin] Shandong Univ Tradit Chinese Med, Affiliated Hosp, Jinan, Shandong, Peoples R China.
   [Yu, Pingping; Nie, Zhen] Wendeng Dist Peoples Hosp Weihai City, Weihai, Shandong, Peoples R China.
   [Wang, Ning; Zhang, Xin] Shandong Univ Tradit Chinese Med, Jinan, Shandong, Peoples R China.
C3 Shandong First Medical University & Shandong Academy of Medical
   Sciences; Shandong University of Traditional Chinese Medicine; Shandong
   University of Traditional Chinese Medicine
RP Zhang, X (corresponding author), Shandong Univ Tradit Chinese Med, Affiliated Hosp, Jinan, Shandong, Peoples R China.; Zhang, X (corresponding author), Shandong Univ Tradit Chinese Med, Jinan, Shandong, Peoples R China.
EM doctorzhangxin@163.com
FX The author(s) declare that no financial support was received for the
   research and/or publication of this article.
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NR 37
TC 0
Z9 0
U1 0
U2 0
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD APR 15
PY 2025
VL 16
AR 1559413
DI 10.3389/fendo.2025.1559413
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 2AN9D
UT WOS:001478055100001
PM 40303636
DA 2025-06-11
ER

PT J
AU Sánchez, PH
   Ruano, C
   de Irala, J
   Ruiz-Canela, M
   Martínez-González, MA
   Sánchez-Villegas, A
AF Henriquez Sanchez, P.
   Ruano, C.
   de Irala, J.
   Ruiz-Canela, M.
   Martinez-Gonzalez, M. A.
   Sanchez-Villegas, A.
TI Adherence to the Mediterranean diet and quality of life in the SUN
   Project
SO EUROPEAN JOURNAL OF CLINICAL NUTRITION
LA English
DT Article
DE Mediterranean diet; quality of life; mental health; physical health
ID POLYUNSATURATED FATTY-ACIDS; FOOD-CONSUMPTION FREQUENCY; SF-36 HEALTH
   SURVEY; DEPRESSIVE SYMPTOMS; PROSPECTIVE COHORT; SPANISH VERSION;
   VEGETABLE CONSUMPTION; EUROPEAN COUNTRIES; METABOLIC SYNDROME; PERCEIVED
   STRESS
AB Background/Objectives: Mediterranean diet has been related with reduced morbidity and better well-being. The aim of this study was to assess whether the adherence to the Mediterranean diet were associated with mental and physical health related to quality of life.
   Subjects/Methods: This analysis included 11 015 participants with 4 years of follow-up in the SUN Project (a multipurpose cohort study based on university graduates from Spain). A validated 136-item food frequency questionnaire was used to assess the adherence to the Mediterranean diet at baseline, according to a nine-point score, presented in four categories (low, low-moderate, moderate-high and high). Health-related quality of life (HRQL) was measured after 4 years of follow-up with the Spanish version of the SF-36 Health Survey. Generalized Linear Models were fitted to assess adjusted mean scores, the regression coefficients (beta) and their 95% confidence intervals (95% CIs) for the SF-36 domains according to categories of adherence to Mediterranean diet.
   Results: Multivariate-adjusted models revealed a significant direct association between adherence to Mediterranean diet and all the physical and most mental health domains (vitality, social functioning and role emotional). Vitality (beta=0.50, 95% CI=0.32-0.68) and general health (beta=0.45, 95% CI=0.26-0.62) showed the highest coefficients. Mean values for physical functioning, role physical, bodily pain, general health and vitality domains were significantly better with increasing adherence to the Mediterranean diet. Those having improved their initial high diet scores have better scores in physical functioning, general health and vitality.
   Conclusions: Adherence to the Mediterranean diet seems to be a factor importantly associated with a better HRQL. European Journal of Clinical Nutrition (2012) 66, 360-368; doi: 10.1038/ejcn.2011.146; published online 17 August 2011
C1 [Henriquez Sanchez, P.] Univ Las Palmas Gran Canaria, Ctr Hlth Sci, Dept Clin Sci, Las Palmas Gran Canaria 35080, Las Palmas, Spain.
   [de Irala, J.; Ruiz-Canela, M.; Martinez-Gonzalez, M. A.; Sanchez-Villegas, A.] Univ Navarra, Dept Prevent Med & Publ Hlth, Navarra, Spain.
C3 Universidad de Las Palmas de Gran Canaria; University of Navarra
RP Sánchez, PH (corresponding author), Univ Las Palmas Gran Canaria, Ctr Hlth Sci, Dept Clin Sci, POB 550, Las Palmas Gran Canaria 35080, Las Palmas, Spain.
EM phenriquez@dcc.ulpgc.es
RI Ruiz-Canela, Miguel/JYP-1794-2024; Martinez-Gonzalez,
   Miguel/AAE-7669-2019; Sanchez-Villegas, Almudena/T-6733-2019;
   Ruiz-Canela, Miguel/I-7738-2016; DE IRALA, JOKIN/H-2936-2017
OI Ruiz-Canela, Miguel/0000-0002-7684-2787; Martinez-Gonzalez, Miguel
   A./0000-0002-3917-9808; DE IRALA, JOKIN/0000-0002-7249-6581; Sanchez
   Villegas, Almudena/0000-0001-7733-9238
FU Spanish Government Instituto de Salud Carlos III, Fondo de
   Investigaciones Sanitarias [PI042241, PI040233, PI050976, PI070240,
   PI0801943, RD 06/0045]; Navarra Regional Government [PI41/2005]
FX We are indebted to the participants of the SUN Study for their continued
   cooperation and participation. We thank to other members of the SUN
   Group: A Alonso, I Ara, FJ Basterra-Gortari, S Benito, M Bes-Rastrollo,
   JJ Beunza, M Delgado-Rodriguez, T Dierssen, J Doreste, F Guillen-Grima,
   J Krafka, J Llorca, C Lopez del Burgo, A Marti, JA Martinez, JM
   Nunez-Cordoba, AM Pimenta, D Sanchez, M Segui-Gomez, M Serrano-Martinez
   and Z Vazquez. The Spanish Government Instituto de Salud Carlos III,
   Fondo de Investigaciones Sanitarias, projects PI042241, PI040233,
   PI050976, PI070240, PI0801943, and RD 06/0045 and the Navarra Regional
   Government project PI41/2005 have supported the SUN Project.
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NR 55
TC 128
Z9 139
U1 0
U2 30
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0954-3007
EI 1476-5640
J9 EUR J CLIN NUTR
JI Eur. J. Clin. Nutr.
PD MAR
PY 2012
VL 66
IS 3
BP 360
EP 368
DI 10.1038/ejcn.2011.146
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 906XM
UT WOS:000301382400010
PM 21847137
DA 2025-06-11
ER

PT J
AU Rüster, C
   Wolf, G
AF Ruester, Christiane
   Wolf, Gunter
TI Adipokines promote chronic kidney disease
SO NEPHROLOGY DIALYSIS TRANSPLANTATION
LA English
DT Review
DE adipokine; endothelial dysfunction; inflammation; kidney disease;
   oxidative stress
ID SYMPATHETIC-NERVE ACTIVITY; GLOMERULAR-FILTRATION-RATE; SERUM LEPTIN
   LEVELS; PLASMA ADIPONECTIN; RENAL INJURY; RESISTIN; INFLAMMATION;
   ASSOCIATION; VISFATIN; ALBUMINURIA
AB The rapid growth in obesity worldwide contributes to an increase in metabolic syndrome and obesity-related kidney disease with an enhanced increased risk for chronic kidney disease, finally progressing to end-stage renal disease. Adipose tissue is a highly active endocrine organ secreting numerous factors that contribute to renal and cardiovascular complications. In renal damage, various adipokines are involved through mediating endothelial dysfunction, inducing oxidative stress and inflammation as well as stimulating renal sympathetic nervous activity, and it reduces cancellous bone but conversely increases cortical bone. Adipokines may also be involved in the development of renal anaemia. A balance exists between more protective adipokines (adiponectin) and factors mediating pathophysiological effects (angiotensin II, TNF alpha). Obesity may cause a disruption of this delicate balance, thereby inducing renal disease. Consequently, weight reduction and lifestyle changes affecting all components of the metabolic syndrome are essential to disrupt this vicious cycle.
C1 [Ruester, Christiane; Wolf, Gunter] Univ Hosp, Dept Internal Med 3, Jena, Germany.
C3 Friedrich Schiller University of Jena
RP Wolf, G (corresponding author), Univ Hosp, Dept Internal Med 3, Jena, Germany.
EM gunter.wolf@med.uni-jena.de
FU Deutsche Forschungsgemeinschaft [W0 460-14-2, 17-1]
FX Original work in the authors' laboratory has been supported by grants
   from the Deutsche Forschungsgemeinschaft (W0 460-14-2, 17-1)
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NR 49
TC 56
Z9 59
U1 0
U2 1
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0931-0509
EI 1460-2385
J9 NEPHROL DIAL TRANSPL
JI Nephrol. Dial. Transplant.
PD NOV
PY 2013
VL 28
SU 4
BP 8
EP 14
DI 10.1093/ndt/gft191
PG 7
WC Transplantation; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Transplantation; Urology & Nephrology
GA 249AN
UT WOS:000326749000002
PM 24179016
OA Bronze
DA 2025-06-11
ER

PT J
AU Bacopoulou, F
   Angelopoulos, NG
   Papadodima, S
   Apostolaki, D
   Mantzou, A
   Koniari, E
   Efthymiou, V
   Tsitsika, A
   Vlachakis, D
   Charmandari, E
   Stefanaki, C
AF Bacopoulou, Flora
   Angelopoulos, Nikolaos G.
   Papadodima, Stavroula
   Apostolaki, Despoina
   Mantzou, Aimilia
   Koniari, Eleni
   Efthymiou, Vasiliki
   Tsitsika, Artemis
   Vlachakis, Dimitrios
   Charmandari, Evangelia
   Stefanaki, Charikleia
TI Serum concentrations of BDNF in adolescents with metabolic syndrome: a
   case-control study between normal-BMI adolescents and adolescents with
   obesity
SO EUROPEAN JOURNAL OF PEDIATRICS
LA English
DT Article
DE Adolescents; Obesity; Brain derived neurotrophic factor; BDNF; Metabolic
   syndrome
ID NEUROTROPHIC FACTOR BDNF; BRAIN; PLASMA; EXERCISE; ASSOCIATION;
   OVERWEIGHT; DEPRESSION; CHILDREN; DISEASE; SEX
AB Brain-Derived Neurotrophic Factor (BDNF) has been linked to various conditions of the cardiovascular and nervous systems. Scarce data exist about the concentrations of BDNF in children and adolescents in relation with obesity and metabolic syndrome (MetS). The aim of this study was to examine the serum BDNF concentrations in adolescents with metabolic syndrome and according to their body mass index (BMI) status. This was a case-control study, assessing BDNF concentrations between adolescents with MetS (with obesity vs. normal-BMI), in relation to sex, anthropometric, metabolic and endocrine parameters. Participants included male and female adolescents, whose anthropometric and metabolic panel, as well as serum BDNF concentrations were measured. A total of 59 adolescents (obesity: 29; normal-BMI: 30) were included in the study. Increased serum BDNF concentrations were observed in MetS adolescents with obesity when compared with normal-BMI adolescents (p < 0.001). Males exhibited higher concentrations of BDNF than females (p = 0.045). The sample was further divided into four categories by sex and BMI status, with normal-BMI females exhibiting significantly lower BDNF concentrations than females and males with obesity(p = 0.005). In the entire study sample, serum BDNF concentrations correlated positively with BMI z-scores, however, this statistical significance was preserved only in the females of the sample. No statistical difference was observed between males of different BMI z-scores categories.
   Conclusion: Obesity appeared as a major factor for increased serum BDNF concentrations in adolescents with MetS (vs. normal-BMI), with a higher impact on BDNF concentrations in females than males.
C1 [Bacopoulou, Flora; Angelopoulos, Nikolaos G.; Apostolaki, Despoina; Stefanaki, Charikleia] Natl & Kapodistrian Univ Athens, Aghia Sophia Childrens Hosp, Ctr Adolescent Med, Med Sch,Dept Pediat 1, Athens 11527, Greece.
   [Bacopoulou, Flora; Angelopoulos, Nikolaos G.; Apostolaki, Despoina; Stefanaki, Charikleia] Natl & Kapodistrian Univ Athens, Aghia Sophia Childrens Hosp, UNESCO Chair Adolescent Hlth Care, Med Sch,Dept Pediat 1, Athens 11527, Greece.
   [Bacopoulou, Flora; Efthymiou, Vasiliki; Vlachakis, Dimitrios; Stefanaki, Charikleia] Natl & Kapodistrian Univ Athens, Univ Res Inst Maternal & Child Hlth & Precis Med, Med Sch, Athens 11527, Greece.
   [Papadodima, Stavroula] Natl & Kapodistrian Univ Athens, Med Sch, Dept Forens Med & Toxicol, Athens 11527, Greece.
   [Mantzou, Aimilia; Koniari, Eleni] Natl & Kapodistrian Univ Athens, Aghia Sophia Childrens Hosp, Med Sch, Dept Pediat 1,Unit Clin & Translat Res Endocrinol, 1 Thivon St, Athens 11527, Greece.
   [Tsitsika, Artemis] Natl & Kapodistrian Univ Athens, P&A Kyriakou Childrens Hosp, Med Sch, Dept Pediat 2,MSc Strategies Dev & Adolescent Hlth, Athens 11527, Greece.
   [Vlachakis, Dimitrios] Agr Univ Athens, Sch Appl Biol & Biotechnol, Dept Biotechnol, Lab Genet, Athens 11855, Greece.
   [Charmandari, Evangelia] Natl & Kapodistrian Univ Athens, Aghia Sophia Childrens Hosp, Med Sch, Dept Pediat 1,Div Endocrinol Metab & Diabet, Athens 11527, Greece.
   [Charmandari, Evangelia] Acad Athens, Ctr Clin Expt Surg & Translat Res, Div Endocrinol & Metab, Biomed Res Fdn, Athens 11527, Greece.
   [Stefanaki, Charikleia] Natl & Kapodistrian Univ Athens, Dept Pediat 1, Thivon & Levadeias Str, Athens 11527, Greece.
C3 National & Kapodistrian University of Athens; The Aghia Sophia
   Children's Hospital; National & Kapodistrian University of Athens; The
   Aghia Sophia Children's Hospital; National & Kapodistrian University of
   Athens; National & Kapodistrian University of Athens; National &
   Kapodistrian University of Athens; The Aghia Sophia Children's Hospital;
   National & Kapodistrian University of Athens; Agricultural University of
   Athens; National & Kapodistrian University of Athens; The Aghia Sophia
   Children's Hospital; Academy of Athens; National & Kapodistrian
   University of Athens
RP Stefanaki, C (corresponding author), Natl & Kapodistrian Univ Athens, Aghia Sophia Childrens Hosp, Ctr Adolescent Med, Med Sch,Dept Pediat 1, Athens 11527, Greece.; Stefanaki, C (corresponding author), Natl & Kapodistrian Univ Athens, Aghia Sophia Childrens Hosp, UNESCO Chair Adolescent Hlth Care, Med Sch,Dept Pediat 1, Athens 11527, Greece.; Stefanaki, C (corresponding author), Natl & Kapodistrian Univ Athens, Univ Res Inst Maternal & Child Hlth & Precis Med, Med Sch, Athens 11527, Greece.; Stefanaki, C (corresponding author), Natl & Kapodistrian Univ Athens, Dept Pediat 1, Thivon & Levadeias Str, Athens 11527, Greece.
EM cstefanaki@gmail.com
RI Stefanaki, Charikleia/G-6653-2012; Charmandari, Evangelia/AAF-2038-2019;
   Bacopoulou, Flora/AAH-1218-2019; Efthymiou, Vasiliki/GWC-7978-2022;
   Tsitsika, Artemis/AAD-5545-2020; Vlachakis, Dimitrios/O-4323-2018
OI Vlachakis, Dimitrios/0000-0003-1823-6102; Stefanaki,
   Charikleia/0000-0003-1634-701X
FU HEAL-Link Greece
FX Open access funding provided by HEAL-Link Greece.
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NR 42
TC 2
Z9 2
U1 0
U2 3
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0340-6199
EI 1432-1076
J9 EUR J PEDIATR
JI Eur. J. Pediatr.
PD OCT
PY 2023
VL 182
IS 10
BP 4595
EP 4603
DI 10.1007/s00431-023-05129-3
EA AUG 2023
PG 9
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA W0FF6
UT WOS:001044200600001
PM 37548699
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Salvio, G
   Ciarloni, A
   Cutini, M
   delli Muti, N
   Finocchi, F
   Perrone, M
   Rossi, S
   Balercia, G
AF Salvio, Gianmaria
   Ciarloni, Alessandro
   Cutini, Melissa
   delli Muti, Nicola
   Finocchi, Federica
   Perrone, Michele
   Rossi, Silvia
   Balercia, Giancarlo
TI Metabolic Syndrome and Male Fertility: Beyond Heart Consequences of a
   Complex Cardiometabolic Endocrinopathy
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE couple infertility; sterility; sperm quality; abnormal semen analysis;
   overweight; obesity; visceral fat; cardiovascular risk
ID C-REACTIVE PROTEIN; OXIDATIVE STRESS; INSULIN-RESISTANCE; LIFE-STYLE;
   REPRODUCTIVE FUNCTION; LIPID-PEROXIDATION; DIABETES-MELLITUS; HUMAN
   SPERMATOZOA; SEMEN PARAMETERS; SPERM FUNCTION
AB Metabolic syndrome (MetS) is a highly prevalent condition among adult males, affecting up to 41% of men in Europe. It is characterized by the association of obesity, hypertension, and atherogenic dyslipidemia, which lead to premature morbidity and mortality due to cardiovascular disease (CVD). Male infertility is another common condition which accounts for about 50% of cases of couple infertility worldwide. Interestingly, male infertility and MetS shares several risk factors (e.g., smoking, ageing, physical inactivity, and excessive alcohol consumption), leading to reactive oxygen species (ROS) production and increased oxidative stress (OS), and resulting in endothelial dysfunction and altered semen quality. Thus, the present narrative review aims to discuss the pathophysiological mechanisms which link male infertility and MetS and to investigate the latest available evidence on the reproductive consequences of MetS.
C1 [Salvio, Gianmaria; Ciarloni, Alessandro; Cutini, Melissa; delli Muti, Nicola; Finocchi, Federica; Perrone, Michele; Rossi, Silvia; Balercia, Giancarlo] Polytech Univ Marche, Dept Clin & Mol Sci DISCLIMO, Div Endocrinol, I-60126 Ancona, Italy.
C3 Marche Polytechnic University
RP Balercia, G (corresponding author), Polytech Univ Marche, Dept Clin & Mol Sci DISCLIMO, Div Endocrinol, I-60126 Ancona, Italy.
EM g.salvio@pm.univpm.it; a.ciarloni@pm.univpm.it;
   melissa.cutini@ospedaliriuniti.marche.it; nidellimuti@gmail.com;
   f.finocchi@staff.univpm.it; m.perrone@pm.univpm.it;
   s.rossi@pm.univpm.it; g.balercia@staff.univpm.it
RI Ciarloni, Alessandro/KFA-4826-2024; Salvio, Gianmaria/ACO-0596-2022
OI Balercia, Giancarlo/0000-0003-1286-1521; Ciarloni,
   Alessandro/0009-0000-4945-6437; FINOCCHI, FEDERICA/0000-0003-1551-5990;
   delli Muti, Nicola/0000-0002-6555-3330; Salvio,
   Gianmaria/0000-0001-9290-5699
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NR 130
TC 17
Z9 19
U1 3
U2 11
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD MAY
PY 2022
VL 23
IS 10
AR 5497
DI 10.3390/ijms23105497
PG 16
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 1Q2PT
UT WOS:000802536900001
PM 35628307
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Wang, JW
   Rong, XL
   Li, WL
   Yang, YF
   Yamahara, J
   Li, YH
AF Wang, Jianwei
   Rong, Xianglu
   Li, Wenlong
   Yang, Yifan
   Yamahara, Johji
   Li, Yuhao
TI Rhodiola crenulata root ameliorates derangements of glucose and
   lipid metabolism in a rat model of the metabolic syndrome and type 2
   diabetes
SO JOURNAL OF ETHNOPHARMACOLOGY
LA English
DT Article
DE Rhodiola crenulata; Insulin resistance; The metabolic syndrome
ID TISSUE INSULIN-RESISTANCE; GRANATUM FLOWER EXTRACT; FATTY RATS;
   PPAR-ALPHA; NONALCOHOLIC STEATOHEPATITIS; POSTPRANDIAL HYPERGLYCEMIA;
   AFFECTIVE-DISORDERS; MAJOR DEPRESSION; EXPRESSION; DISEASE
AB Ethnopharmacological relevance: Rhodiola species are traditionally used as tonics and stimulants to treat asthenia, suggesting their possible regulatory effect on energy metabolism. Clinical trials have demonstrated their glucose-lowering effect in type 2 diabetes.
   Aim of the study: To examine the effects of Rhodiola on glucose and lipid metabolism in the metabolic syndrome and type 2 diabetes.
   Materials and methods: Zucker diabetic fatty (ZDF) rats were treated with Rhodiola crenulata root (RCR) powder (100 and 500 mg/kg, by gavage, once daily for 4 weeks). In addition, the effects of RCR on sucrose-induced acute hyperglycemia in mice and olive oil-induced hypertriglyceridemia in rats were also examined. Biochemical variables were determined enzymatically or by ELISA.
   Results: In ZDF rats, RCR treatment decreased the increased plasma insulin and triglyceride concentrations at baseline, the index of the homeostasis model assessment of insulin resistance (HOMA-IR) and excessive hepatic triglyceride accumulation. This treatment also inhibited abnormal increases in plasma glucose and insulin concentrations during oral glucose tolerance test. Furthermore, RCR reversed the increased adipose insulin resistance index, and accelerated the decline of plasma concentrations of non-esterified fatty acids after exogenous glucose stimulation. However, RCR minimally affected sucrose-induced acute hyperglycemia in mice and olive oil-induced acute hypertriglyceridemia in rats.
   Conclusions: The present results demonstrate that RCR treatment improves metabolic derangements in animal model of the metabolic syndrome and type 2 diabetes. Our findings may provide new pharmacological basis of therapeutics for the adaptogenic plants to treat metabolic derangements-associated disorders, such as asthenia. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
C1 [Yang, Yifan; Li, Yuhao] Sydney Inst Hlth Sci, Endocrinol & Metab Grp, Sydney, NSW 2000, Australia.
   [Wang, Jianwei] Chongqing Med Univ, Fac Basic Med Sci, Chongqing, Peoples R China.
   [Rong, Xianglu] Guangzhou Univ Chinese Med, Dept Pharmacol, Guangzhou, Guangdong, Peoples R China.
   [Li, Wenlong] Univ Sydney, Sch Med, Sydney, NSW 2006, Australia.
   [Yamahara, Johji] Pharmafood Inst, Kyoto, Japan.
C3 Chongqing Medical University; Guangzhou University of Chinese Medicine;
   University of Sydney
RP Li, YH (corresponding author), Sydney Inst Hlth Sci, Endocrinol & Metab Grp, Level 5,545 Kent St, Sydney, NSW 2000, Australia.
EM yuhao@sitcm.edu.au
FU R&D Agency for Curative Natural Products, Kyoto, Japan
FX The authors thank Kiwa Laboratory Animals, Wakayama, Japan, for their
   assistances in the maintenance of animals. This work was financially
   supported by R&D Agency for Curative Natural Products (a Japanese
   government-registered non-profit organization), Kyoto, Japan.
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NR 47
TC 53
Z9 56
U1 1
U2 29
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0378-8741
J9 J ETHNOPHARMACOL
JI J. Ethnopharmacol.
PD AUG 1
PY 2012
VL 142
IS 3
BP 782
EP 788
DI 10.1016/j.jep.2012.05.063
PG 7
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA 982IB
UT WOS:000307035300025
PM 22683493
DA 2025-06-11
ER

PT J
AU Gálvez, I
   Martín-Cordero, L
   Hinchado, MD
   Alvarez-Barrientos, A
   Ortega, E
AF Galvez, Isabel
   Martin-Cordero, Leticia
   Dolores Hinchado, Maria
   Alvarez-Barrientos, Alberto
   Ortega, Eduardo
TI Obesity Affects β2 Adrenergic Regulation of the Inflammatory Profile and
   Phenotype of Circulating Monocytes from Exercised Animals
SO NUTRIENTS
LA English
DT Article
DE beta 2 adrenergic receptors; terbutaline; obesity; exercise; monocytes;
   inflammation; cytokines; Ly6C; iNOS; arginase
ID METABOLIC SYNDROME-X; BETA-ADRENOCEPTORS; IMMUNE-SYSTEM; MACROPHAGES;
   STRESS; NOREPINEPHRINE; NORADRENALINE; INHIBITION; MODULATION;
   ACTIVATION
AB Anomalous immune/inflammatory responses in obesity take place along with alterations in the neuroendocrine responses and dysregulation in the immune/stress feedback mechanisms. Exercise is a potential anti-inflammatory strategy in this context, but the influence of exercise on the beta 2 adrenergic regulation of the monocyte-mediated inflammatory response in obesity remains completely unknown. The first objective of this study was to analyze the effect of exercise on the inflammatory profile and phenotype of monocytes from obese and lean animals, and the second aim was to determine whether obesity could affect monocytes' inflammatory response to beta 2 adrenergic activation in exercised animals. C57BL/6J mice were allocated to different lean or obese groups: sedentary, with acute exercise, or with regular exercise. The inflammatory profile and phenotype of their circulating monocytes were evaluated by flow cytometry in the presence or absence of the selective beta 2 adrenergic receptor agonist terbutaline. Exercise caused an anti-inflammatory effect in obese individuals and a pro-inflammatory effect in lean individuals. beta 2 adrenergic receptor stimulation exerted a global pro-inflammatory effect in monocytes from exercised obese animals and an anti-inflammatory effect in monocytes from exercised lean animals. Thus, beta 2 adrenergic regulation of inflammation in monocytes from exercised animals seems to depend on the inflammatory basal set-point.
C1 [Galvez, Isabel; Dolores Hinchado, Maria; Ortega, Eduardo] Univ Extremadura, Dept Fisiol, Fac Ciencias, Grp Invest Inmunofisiol, E-06071 Badajoz, Spain.
   [Galvez, Isabel; Martin-Cordero, Leticia; Dolores Hinchado, Maria; Ortega, Eduardo] Inst Univ Invest Biosanitaria Extremadura INUBE, Badajoz 06071, Spain.
   [Martin-Cordero, Leticia] Univ Extremadura, Ctr Univ Plasencia, Dept Enfermeria, Grp Invest Inmunofisiol, Plasencia 10600, Spain.
   [Alvarez-Barrientos, Alberto] Univ Extremadura, STAB, E-06071 Badajoz, Spain.
C3 Universidad de Extremadura; Universidad de Extremadura; Universidad de
   Extremadura
RP Ortega, E (corresponding author), Univ Extremadura, Dept Fisiol, Fac Ciencias, Grp Invest Inmunofisiol, E-06071 Badajoz, Spain.; Ortega, E (corresponding author), Inst Univ Invest Biosanitaria Extremadura INUBE, Badajoz 06071, Spain.
EM igalvez@unex.es; leticiamartin@unex.es; mhinsan@unex.es;
   alalvarez@unex.es; orincon@unex.es
RI Galvez, Isabel/LFS-2823-2024; Ortega, Eduardo/GXN-2560-2022; Ortega,
   Eduardo/H-9891-2016; Alvarez-Barrientos, Alberto/L-9299-2014;
   Martin-Cordero, Leticia/H-9711-2015
OI Ortega, Eduardo/0000-0002-7007-7615; Galvez, Isabel/0000-0002-4294-4507;
   HINCHADO SANCHEZ-MORO, MARIA DOLORES/0000-0002-9709-4714;
   Alvarez-Barrientos, Alberto/0000-0003-4761-0212; Martin-Cordero,
   Leticia/0000-0002-3651-2265
FU Ministerio de Ciencia, Innovacion, y Universidades, Spain
   [DEP2015-66093-R]; Gobierno de Extremadura-Fondo Europeo de Desarrollo
   Regional, Spain [GR18009, IB18011]; 'Formacion del Profesorado
   Universitario (FPU)' pre-doctoral contract from the Ministerio de
   Ciencia, Innovacion y Universidades, Spain [FPU15/02395]
FX This work was partially supported by the Ministerio de Ciencia,
   Innovacion, y Universidades, Spain [DEP2015-66093-R] and the Gobierno de
   Extremadura-Fondo Europeo de Desarrollo Regional, Spain [GR18009;
   IB18011]. I.G. is recipient of a `Formacion del Profesorado
   Universitario (FPU)' pre-doctoral contract under grant FPU15/02395 from
   the Ministerio de Ciencia, Innovacion y Universidades, Spain. Funding
   sources had no role in the study design, collection, analysis, and
   interpretation of the data or the decision to submit the manuscript for
   publication.
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NR 53
TC 11
Z9 11
U1 1
U2 5
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD NOV
PY 2019
VL 11
IS 11
AR 2630
DI 10.3390/nu11112630
PG 16
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA JV3OC
UT WOS:000502274600081
PM 31684076
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Del Hierro, JN
   Cantero-Bahillo, E
   Fernández-Felipe, MT
   García-Risco, MR
   Fornari, T
   Rada, P
   Doblado, L
   Ferreira, V
   Hitos, AB
   Valverde, AM
   Monsalve, M
   Martin, D
AF Navarro Del Hierro, Joaquin
   Cantero-Bahillo, Emma
   Teresa Fernandez-Felipe, M.
   Garcia-Risco, Monica R.
   Fornari, Tiziana
   Rada, Patricia
   Doblado, Laura
   Ferreira, Vitor
   Hitos, Ana B.
   Valverde, Angela M.
   Monsalve, Maria
   Martin, Diana
TI Effects of a Mealworm (Tenebrio molitor) Extract on Metabolic
   Syndrome-Related Pathologies: In Vitro Insulin Sensitivity, Inflammatory
   Response, Hypolipidemic Activity and Oxidative Stress
SO INSECTS
LA English
DT Article
DE Tenebrio molitor; bioactive extract; DPPH; pancreatic lipase;
   cholesterol; mitochondrial respiration; inflammation; insulin
   sensitivity; reactive oxygen species
ID PANCREATIC LIPASE; PROLINE
AB Simple Summary Among edible insects, mealworm has gained attention due to its proven beneficial effects; however, mealworm products other than flour, such as concentrated forms or extracts different to proteins, are still rare. This novel food source can have a positive impact on multiple diseases such as via the metabolic syndrome. Our objective was to describe the composition of a mealworm extract and study its effect on metabolic syndrome-related pathologies. The extract interfered with the absorption of cholesterol and partially blocked the digestion of fats. It also reduced the inflammatory response, enhanced the sensitivity to insulin and showed strong antioxidant potential. Mealworm extract might be an interesting candidate for ameliorating the risk factors associated with the metabolic syndrome. The mealworm (Tenebrio molitor Linnaeus 1758) is gaining importance as one of the most popular edible insects. Studies focusing on its bioactivities are increasing, although alternative forms of consumption other than the whole insect or flour, such as bioactive non-protein extracts, remain underexplored. Furthermore, the incidence of metabolic syndrome-related pathologies keeps increasing, hence the importance of seeking novel natural sources for reducing the impact of certain risk factors. The aim was to study the potential of a non-protein mealworm extract on metabolic syndrome-related pathologies, obtained with ethanol:water (1:1, v/v) by ultrasound-assisted extraction. We characterized the extract by gas-chromatography mass-spectrometry and assessed its hypolipidemic potential, its ability to scavenger free radicals, to attenuate the inflammatory response in microglial cells, to affect mitochondrial respiration and to enhance insulin sensitivity in mouse hepatocytes. The extract contained fatty acids, monoglycerides, amino acids, certain acids and sugars. The mealworm extract caused a 30% pancreatic lipase inhibition, 80% DPPH center dot scavenging activity and 55.9% reduction in the bioaccessibility of cholesterol (p = 0.009). The extract was effective in decreasing iNOS levels, increasing basal, maximal and ATP coupled respiration as well as enhancing insulin-mediated AKT phosphorylation at low insulin concentrations (p < 0.05). The potential of a non-protein bioactive mealworm extract against metabolic syndrome-related pathologies is shown, although further studies are needed to elucidate the mechanisms and relationship with compounds.
C1 [Navarro Del Hierro, Joaquin; Cantero-Bahillo, Emma; Teresa Fernandez-Felipe, M.; Garcia-Risco, Monica R.; Fornari, Tiziana; Martin, Diana] Inst Invest Ciencias Alimentac CIAL CSIC UAM, Dept Prod & Caracterizac Nuevos Alimentos, Madrid 28049, Spain.
   [Navarro Del Hierro, Joaquin; Cantero-Bahillo, Emma; Teresa Fernandez-Felipe, M.; Garcia-Risco, Monica R.; Fornari, Tiziana; Martin, Diana] Univ Autonoma Madrid, Fac Ciencias, Secc Dept Ciencias Alimentac, Madrid 28029, Spain.
   [Rada, Patricia; Doblado, Laura; Ferreira, Vitor; Hitos, Ana B.; Valverde, Angela M.; Monsalve, Maria] Inst Invest Biomed Alberto Sols CSIC UAM, Madrid 28049, Spain.
   [Rada, Patricia; Ferreira, Vitor; Hitos, Ana B.; Valverde, Angela M.] Inst Salud Carlos III, Ctr Invest Biomed Red Diabet & Enfermedades Metab, Madrid 28029, Spain.
C3 Consejo Superior de Investigaciones Cientificas (CSIC); CSIC-UAM -
   Instituto de Investigacion en Ciencias de la Alimentacion (CIAL);
   Autonomous University of Madrid; Consejo Superior de Investigaciones
   Cientificas (CSIC); CSIC - Instituto de Investigaciones Biomedicas
   Alberto Sols (IIBM); CIBER - Centro de Investigacion Biomedica en Red;
   CIBERDEM; Instituto de Salud Carlos III
RP Martin, D (corresponding author), Inst Invest Ciencias Alimentac CIAL CSIC UAM, Dept Prod & Caracterizac Nuevos Alimentos, Madrid 28049, Spain.; Martin, D (corresponding author), Univ Autonoma Madrid, Fac Ciencias, Secc Dept Ciencias Alimentac, Madrid 28029, Spain.
EM diana.martin@uam.es
RI Monsalve, Maria/K-4416-2014; del Hierro, Joaquín/AAZ-1023-2020;
   Cantero-Bahillo, Emma/GXH-7051-2022; Rodríguez, Mónica/AAA-7138-2019;
   Ferreira, Vitor/AAA-3435-2022; Martin, Diana/F-7465-2014; Rada Llano,
   Patricia/G-7300-2015
OI Martin, Diana/0000-0002-1082-9280; Ferreira, Vitor/0000-0002-0107-9510;
   Cantero-Bahillo, Emma/0000-0002-6004-1328; Doblado Bueno,
   Laura/0000-0003-1186-2100; Rada Llano, Patricia/0000-0002-6731-2098;
   Navarro del Hierro, Joaquin/0000-0001-8895-2388; Martinez Valverde,
   Angela/0000-0003-1192-9045
FU Community of Madrid (Spain) [ALIBIRD2020CMS2018/BAA-4343]; Ministerio de
   Ciencia e Innovacion [PID2021-122766OB-100, PID2021-122765OB-I00];
   Agencia Estatal de Investigacion [PID2021-122766OB-100,
   PID2021-122765OB-I00]; ERDF-A way of making Europe; European Union;
   European Union's Horizon 2020 research and innovation program under the
   Marie Sklodowska-Curie grant [721236-TREATMENT]
FX This research was funded by the Community of Madrid (Spain), grant
   number ALIBIRD2020CMS2018/BAA-4343; Ministerio de Ciencia e Innovacion
   and Agencia Estatal de Investigacion, grants PID2021-122766OB-100 and
   PID2021-122765OB-I00; and "ERDF-A way of making Europe", by the
   "European Union" and the European Union's Horizon 2020 research and
   innovation program under the Marie Sklodowska-Curie grant agreement
   721236-TREATMENT.
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U1 2
U2 13
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2075-4450
J9 INSECTS
JI Insects
PD OCT
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VL 13
IS 10
AR 896
DI 10.3390/insects13100896
PG 18
WC Entomology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Entomology
GA 5R3HQ
UT WOS:000874405100001
PM 36292844
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Gantenbein, KV
   Kanaka-Gantenbein, C
AF Gantenbein, Katherina Vicky
   Kanaka-Gantenbein, Christina
TI Highlighting the trajectory from intrauterine growth restriction to
   future obesity
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Review
DE intrauterine growth restriction; IUGR; metabolic syndrome; obesity;
   offspring; small for gestational age; cardiovascular risk
ID FOR-GESTATIONAL-AGE; MATERNAL THYROID-FUNCTION; BIRTH-WEIGHT GIRLS;
   FETAL-GROWTH; BLOOD-PRESSURE; YOUNG-ADULTS; DEVELOPMENTAL ORIGINS;
   ENDOCRINE REGULATION; METFORMIN TREATMENT; ADAPTIVE RESPONSES
AB During the last decades several lines of evidence reported the association of an adverse intrauterine environment, leading to intrauterine restriction, with future disease, such as obesity and metabolic syndrome, both leading to increased cardiovascular and cancer risk. The underlying explanation for this association has firstly been expressed by the Barker's hypothesis, the "thrifty phenotype hypothesis". According to this hypothesis, a fetus facing an adverse intrauterine environment adapts to this environment through a reprogramming of its endocrine-metabolic status, during the crucial window of developmental plasticity to save energy for survival, providing less energy and nutrients to the organs that are not essential for survival. This theory evolved to the concept of the developmental origin of health and disease (DOHaD). Thus, in the setting of an adverse, f. ex. protein restricted intrauterine environment, while the energy is mainly directed to the brain, the peripheral organs, f.ex. the muscles and the liver undergo an adaptation that is expressed through insulin resistance. The adaptation at the hepatic level predisposes to future dyslipidemia, the modifications at the vascular level to endothelial damage and future hypertension and, overall, through the insulin resistance to the development of metabolic syndrome. All these adaptations are suggested to take place through epigenetic modifications of the expression of genes without change of their amino-acid sequence. The epigenetic modifications leading to future obesity and cardiovascular risk are thought to induce appetite dysregulation, promoting food intake and adipogenesis, facilitating obesity development. The epigenetic modifications may even persist into the next generation even though the subsequent generation has not been exposed to an adverse intrauterine environment, a notion defined as the "transgenerational transfer of environmental information". As a consequence, if the increased public health burden and costs of non-communicable chronic diseases such as obesity, hypertension, metabolic syndrome and type 2 diabetes have to be minimized, special attention should be laid to the healthy lifestyle habits of women of reproductive age, including healthy diet and physical activity to be established long before any pregnancy takes place in order to provide the best conditions for both somatic and mental health of future generations.
C1 [Gantenbein, Katherina Vicky] Univ Childrens Hosp Zurich, Swiss Childrens Rehab, Zurich, Switzerland.
   [Kanaka-Gantenbein, Christina] Natl & Kapodistrian Univ Athens, Aghia Sophia Childrens Hosp, Dept Pediat 1, Div Endocrinol Diabet & Metab,Med Sch, Athens, Greece.
C3 University Children's Hospital Zurich; National & Kapodistrian
   University of Athens; The Aghia Sophia Children's Hospital
RP Kanaka-Gantenbein, C (corresponding author), Natl & Kapodistrian Univ Athens, Aghia Sophia Childrens Hosp, Dept Pediat 1, Div Endocrinol Diabet & Metab,Med Sch, Athens, Greece.
EM chriskan@med.uoa.gr
RI Kanaka-Gantenbein, Christina/AAP-3697-2020
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NR 173
TC 19
Z9 20
U1 3
U2 10
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD NOV 11
PY 2022
VL 13
AR 1041718
DI 10.3389/fendo.2022.1041718
PG 16
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 6O1QJ
UT WOS:000890019700001
PM 36440208
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Raudeniece, J
   Justamente, I
   Ozolina-Moll, L
   Sobolevs, A
   Zolovs, M
   Dela, F
   Reihmane, D
AF Raudeniece, Jelena
   Justamente, Ilze
   Ozolina-Moll, Liga
   Sobolevs, Artjoms
   Zolovs, Maksims
   Dela, Flemming
   Reihmane, Dace
TI Cardiorespiratory Fitness and Body Mass Index as Predictors of Metabolic
   Syndrome in Schoolchildren (PACH Study)
SO DIABETES METABOLIC SYNDROME AND OBESITY
LA English
DT Article
DE cardiorespiratory fitness level; cardiometabolic health; BMI; MVPA;
   pupils
ID CHILDREN; CHILDHOOD; RISK
AB Purpose: Metabolic syndrome (MetS) has become a condition not rarely diagnosed in children and adolescents, leading to changes in physical and mental health. Simple and cost-effective screening methods applied in schools are needed to take preventive measures and reduce the risk of the development of MetS in children. Methods: This prospective longitudinal study aims to investigate the prevalence of MetS and its risk factors in 8-10-year-old schoolchildren (46 boys and 60 girls) over 3 consecutive years. General Linear Mixed Model (GLMM) was used to assess the effect of recommended daily levels of moderate to vigorous physical activity (MVPA), body mass index (BMI), waist circumference (WC), cardiorespiratory fitness (CRF), and obesity level on a new set of orthogonal variables formed from various parameters of MetS (eg blood pressure (BP), lipid panel and glucose homeostasis) determined by Principal Component Analysis (PCA). Results: The prevalence of MetS was 2% in the years 2017, 2018 and 2019, while in 2020 prevalence reached 7.7%. The most prevalent combination of criteria defining MetS syndrome in children was increased WC, BP, and blood triglycerides (TG). PCA identified non-high-density lipoprotein (non-HDL), low-density lipoprotein (LDL), and total cholesterol (TCHOL) as important predictors of metabolic syndrome (MetS). Additionally, cardiorespiratory fitness (CRF) and body mass index (BMI) were found to significantly influence the variance in MetS criteria. However, moderate to vigorous physical activity (MVPA) did not have a notable effect on the variance of these criteria. Conclusion: The prevalence of MetS in children is increasing with age. Non-HDL turned out to be the most influential parameter across all principal components. The CRF, being accessible, simple to use, non-invasive and cost-effective, proved to be a superior predictor of variance of glucose homeostasis compared to BMI.
C1 [Raudeniece, Jelena; Justamente, Ilze; Ozolina-Moll, Liga] Univ Latvia, Fac Biol, Dept Human & Anim Physiol, Jelgavas St 1, LV-1004 Riga, Latvia.
   [Raudeniece, Jelena; Justamente, Ilze; Dela, Flemming; Reihmane, Dace] Riga Stradins Univ, Dept Human Physiol & Biochem, Riga, Latvia.
   [Raudeniece, Jelena; Justamente, Ilze; Reihmane, Dace] Riga Stradins Univ, Lab Sports & Nutr Res, Riga, Latvia.
   [Sobolevs, Artjoms] Univ Latvia, Fac Med, Dept Pathol, Riga, Latvia.
   [Zolovs, Maksims] Riga Stradins Univ, Stat Unit, Riga, Latvia.
   [Zolovs, Maksims] Daugavpils Univ, Inst Life Sci & Technol, Dept Biosystemat, Daugavpils, Latvia.
   [Dela, Flemming] Univ Copenhagen, Fac Hlth & Med Sci, Dept Biomed Sci, Xlab, Copenhagen, Denmark.
   [Raudeniece, Jelena] Univ Latvia, Fac Biol, Dept Human & Anim Physiol, Jelgavas St 1, LV-1004 Riga, Latvia.
C3 University of Latvia; Riga Stradins University; Riga Stradins
   University; University of Latvia; Riga Stradins University; University
   of Daugavpils; University of Copenhagen; University of Latvia
RP Raudeniece, J (corresponding author), Univ Latvia, Fac Biol, Dept Human & Anim Physiol, Jelgavas St 1, LV-1004 Riga, Latvia.; Raudeniece, J (corresponding author), Univ Latvia, Fac Biol, Dept Human & Anim Physiol, Jelgavas St 1, LV-1004 Riga, Latvia.
EM jelena.raudeniece@olimpiade.lv
RI Zolovs, Maksims/GLR-9675-2022; Reihmane, Dace/HPB-8065-2023; Dela,
   Flemming/B-3239-2008
OI Zolovs, Maksims/0000-0001-9120-5869; Raudeniece,
   Jelena/0000-0001-7233-6628; Dela, Flemming/0000-0001-9970-9535
FU University of Latvia [ZD2019/20861]; Latvian Olympic Committee
   [ZD2019/20861]
FX Effective collaboration project "The Physical Activity and Children
   overall Health Study (PACH study): Lifestyle as Human Gut Metagenome
   Modifiable Factor.", Nr. ZD2019/20861 between the University of Latvia
   and the Latvian Olympic Committee.
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NR 55
TC 0
Z9 0
U1 1
U2 1
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-7007
J9 DIABET METAB SYND OB
JI Diabetes Metab. Syndr. Obes.
PY 2024
VL 17
DI 10.2147/DMSO.S487309
PG 13
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA U9G3D
UT WOS:001414783000001
PM 39665085
OA gold
DA 2025-06-11
ER

PT J
AU McGill, JB
   Johnson, M
   Hurst, S
   Cade, WT
   Yarasheski, KE
   Ostlund, RE
   Schechtman, KB
   Razani, B
   Kastan, MB
   McClain, DA
   de las Fuentes, L
   Davila-Roman, VG
   Ory, DS
   Wickline, SA
   Semenkovich, CF
AF McGill, Janet B.
   Johnson, Mariko
   Hurst, Stacy
   Cade, William T.
   Yarasheski, Kevin E.
   Ostlund, Richard E.
   Schechtman, Kenneth B.
   Razani, Babak
   Kastan, Michael B.
   McClain, Donald A.
   de las Fuentes, Lisa
   Davila-Roman, Victor G.
   Ory, Daniel S.
   Wickline, Samuel A.
   Semenkovich, Clay F.
TI Low dose chloroquine decreases insulin resistance in human metabolic
   syndrome but does not reduce carotid intima-media thickness
SO DIABETOLOGY & METABOLIC SYNDROME
LA English
DT Article
DE Chloroquine; Metabolic syndrome; Carotid intima-media thickness; Insulin
   sensitivity; Glucose disposal; Atheroma; Blood pressure; Lipids; JNK
ID ARTERIAL-WALL THICKNESS; MITOCHONDRIAL DYSFUNCTION; CARDIOVASCULAR RISK;
   VASCULAR-DISEASE; CAUSAL ROLE; ATHEROSCLEROSIS; PIOGLITAZONE;
   ASSOCIATION; HYDROXYCHLOROQUINE; ADIPONECTIN
AB BackgroundMetabolic syndrome, an obesity-related condition associated with insulin resistance and low-grade inflammation, leads to diabetes, cardiovascular diseases, cancer, osteoarthritis, and other disorders. Optimal therapy is unknown. The antimalarial drug chloroquine activates the kinase ataxia telangiectasia mutated (ATM), improves metabolic syndrome and reduces atherosclerosis in mice. To translate this observation to humans, we conducted two clinical trials of chloroquine in people with the metabolic syndrome.MethodsEligibility included adults with at least 3 criteria of metabolic syndrome but who did not have diabetes. Subjects were studied in the setting of a single academic health center. The specific hypothesis: chloroquine improves insulin sensitivity and decreases atherosclerosis. In Trial 1, the intervention was chloroquine dose escalations in 3-week intervals followed by hyperinsulinemic euglycemic clamps. Trial 2 was a parallel design randomized clinical trial, and the intervention was chloroquine, 80mg/day, or placebo for 1year. The primary outcomes were clamp determined-insulin sensitivity for Trial 1, and carotid intima-media thickness (CIMT) for Trial 2. For Trial 2, subjects were allocated based on a randomization sequence using a protocol in blocks of 8. Participants, care givers, and those assessing outcomes were blinded to group assignment.ResultsFor Trial 1, 25 patients were studied. Chloroquine increased hepatic insulin sensitivity without affecting glucose disposal, and improved serum lipids. For Trial 2, 116 patients were randomized, 59 to chloroquine (56 analyzed) and 57 to placebo (51 analyzed). Chloroquine had no effect on CIMT or carotid contrast enhancement by MRI, a pre-specified secondary outcome. The pre-specified secondary outcomes of blood pressure, lipids, and activation of JNK (a stress kinase implicated in diabetes and atherosclerosis) were decreased by chloroquine. Adverse events were similar between groups.ConclusionsThese findings suggest that low dose chloroquine, which improves the metabolic syndrome through ATM-dependent mechanisms in mice, modestly improves components of the metabolic syndrome in humans but is unlikely to be clinically useful in this setting.Trial registration ClinicalTrials.gov (NCT00455325, NCT00455403), both posted 03 April 2007
C1 [McGill, Janet B.; Johnson, Mariko; Hurst, Stacy; Yarasheski, Kevin E.; Ostlund, Richard E.; Semenkovich, Clay F.] Washington Univ, Sch Med, Dept Med, Div Endocrinol Metab & Lipid Res, 660 South Euclid Ave,Box 8127, St Louis, MO 63110 USA.
   [Cade, William T.] Washington Univ, Program Phys Therapy, St Louis, MO 63110 USA.
   [Schechtman, Kenneth B.] Washington Univ, Div Biostat, St Louis, MO 63110 USA.
   [Razani, Babak; de las Fuentes, Lisa; Davila-Roman, Victor G.; Ory, Daniel S.; Wickline, Samuel A.] Washington Univ, Div Cardiovasc, St Louis, MO 63110 USA.
   [Kastan, Michael B.] Duke Univ, Dept Pharmacol & Canc Biol, Durham, NC USA.
   [McClain, Donald A.] Wake Forest Sch Med, Dept Internal Med, Winston Salem, NC USA.
   [Semenkovich, Clay F.] Washington Univ, Dept Cell Biol & Physiol, St Louis, MO 63110 USA.
C3 Washington University (WUSTL); Washington University (WUSTL); Washington
   University (WUSTL); Washington University (WUSTL); Duke University; Wake
   Forest University; Washington University (WUSTL)
RP McGill, JB; Semenkovich, CF (corresponding author), Washington Univ, Sch Med, Dept Med, Div Endocrinol Metab & Lipid Res, 660 South Euclid Ave,Box 8127, St Louis, MO 63110 USA.
EM jmcgill@wustl.edu; csemenko@wustl.edu
RI Segura-Aguilar, Juan/H-8839-2013; Ory, Daniel/IAP-9009-2023; wickline,
   samuel/I-2898-2015; Yarasheski, Kevin/AAC-7450-2021
OI Razani, Babak/0000-0002-7172-9240; de las Fuentes,
   Lisa/0000-0002-4689-325X; Yarasheski, Kevin/0000-0001-5436-2451; McGill,
   Janet/0000-0002-6228-6521
FU NIH [HL083762, DK020579, DK076729, DK056341, GM103422, UL1RR024992,
   KL2RR024994]
FX This work was supported by NIH Grants HL083762, DK020579, DK076729,
   DK056341, GM103422, UL1RR024992, KL2RR024994.
CR Azimi-Nezhad M, 2018, AM J MED SCI, V355, P559, DOI 10.1016/j.amjms.2018.03.009
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NR 41
TC 19
Z9 19
U1 0
U2 9
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1758-5996
J9 DIABETOL METAB SYNDR
JI Diabetol. Metab. Syndr.
PD JUL 29
PY 2019
VL 11
AR 61
DI 10.1186/s13098-019-0456-4
PG 16
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA IM3FW
UT WOS:000477879100001
PM 31384309
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Sieczkowska, SM
   Mazzolani, BC
   Smaira, FI
   Romero, M
   Pasoto, SG
   Pinto, ALD
   Lima, FR
   De Oliveira, VR
   Ueda, S
   Benatti, FB
   Roschel, H
   Gualano, B
AF Sieczkowska, Sofia Mendes
   Mazzolani, Bruna Caruso
   Smaira, Fabiana Infante
   Romero, Marina
   Pasoto, Sandra Gofinet
   Pinto, Ana Lucia de Sa
   Lima, Fernanda Rodrigues
   De Oliveira, Victor Rodrigues
   Ueda, Serli
   Benatti, Fabiana Braga
   Roschel, Hamilton
   Gualano, Bruno
TI Effects of a lifestyle intervention on cardiovascular risk factors in
   systemic lupus erythematosus patients: The study "Living well with
   lupus"
SO CLINICAL RHEUMATOLOGY
LA English
DT Article
DE Healthy eating; Lifestyle Intervention; Physical activity; Sedentary
   behavior; Systemic lupus erythematosus
ID DIABETES PREVENTION; INSULIN-RESISTANCE; FOLLOW-UP; DISEASE; EXERCISE;
   INTENSITY; GLUCOSE; MODEL; INDEX
AB ObjectiveThe aim of the present study was to investigate the effects of a lifestyle intervention on cardiometabolic risk factors in patients with systemic lupus erythematosus with a high cardiovascular risk profile.MethodsThis trial was conducted in Sao Paulo, Brazil between August 2020 and March 2023. The patients were randomly assigned to lifestyle intervention or control. The intervention was a 6-month multifaced program focused on behavioral changes through personalized recommendations for increasing physical activity (structured and non-structured) and improving eating aspects. Cardiometabolic risk score (primary outcome), anthropometry and visceral fat, aerobic capacity, blood pressure, inflammatory and oxidative stress markers, and blood flow and endothelial function were assessed before and after the intervention.ResultsA total of 80 patients were randomized. Twelve and 6 patients dropped out due to personal reasons in the intervention and control groups, respectively. Average adherence rate for the intervention was 56.9%. Intention-to-treat analysis showed no significant difference between groups in the cardiometabolic risk score (intervention group - Pre: 1.7 +/- 3.6; Post: -1.6 +/- 4.0; control group - Pre: -1.9 +/- 3.6; Post: -2.0 +/- 3.8; estimated mean difference between groups at post: -0.4; 95% confidence intervals: -2.7; 1.9; p = 0.96). This finding was confirmed by exploratory, per-protocol analysis. No significant differences were observed between adherents vs. non-adherent participants. Secondary outcomes did not change between groups.ConclusionThis 6-month, individualized, lifestyle intervention did not improve cardiovascular risk factors in SLE patients with a high cardiovascular risk profile.Trial Registration:clinicaltrials.gov (NCT04431167).ConclusionThis 6-month, individualized, lifestyle intervention did not improve cardiovascular risk factors in SLE patients with a high cardiovascular risk profile.Trial Registration:clinicaltrials.gov (NCT04431167).
C1 [Sieczkowska, Sofia Mendes; Mazzolani, Bruna Caruso; Smaira, Fabiana Infante; Romero, Marina; Pinto, Ana Lucia de Sa; Lima, Fernanda Rodrigues; Benatti, Fabiana Braga; Roschel, Hamilton; Gualano, Bruno] Univ Sao Paulo, Sch Phys Educ & Sport, Appl Physiol & Nutr Res Grp, Sao Paulo, SP, Brazil.
   [Sieczkowska, Sofia Mendes; Mazzolani, Bruna Caruso; Smaira, Fabiana Infante; Romero, Marina; Pinto, Ana Lucia de Sa; Lima, Fernanda Rodrigues; Benatti, Fabiana Braga; Roschel, Hamilton; Gualano, Bruno] Univ Sao Paulo, Fac Med FMUSP, Sao Paulo, SP, Brazil.
   [Sieczkowska, Sofia Mendes; Mazzolani, Bruna Caruso; Smaira, Fabiana Infante; Roschel, Hamilton; Gualano, Bruno] Univ Sao Paulo, Hosp Clin HCFMUSP, Fac Med FMUSP, Ctr Lifestyle Med,Lab Assessment & Conditioning Rh, Ave Dr Arnaldo 455,3 Andar, BR-01246903 Sao Paulo, SP, Brazil.
   [Romero, Marina; Benatti, Fabiana Braga] Univ Estadual Campinas, Sch Appl Sci, BR-13484350 Campinas, SP, Brazil.
   [Pasoto, Sandra Gofinet; De Oliveira, Victor Rodrigues; Ueda, Serli] Univ Sao Paulo, Hosp Clin HCFMUSP, Fac Med, BR-05403010 Sao Paulo, SP, Brazil.
   [Pinto, Ana Lucia de Sa; Lima, Fernanda Rodrigues; Roschel, Hamilton; Gualano, Bruno] Univ Sao Paulo, Fac Med FMUSP, Rheumatol Div, Ave Dr Arnaldo 455, BR-05403900 Sao Paulo, SP, Brazil.
C3 Universidade de Sao Paulo; Universidade de Sao Paulo; Universidade de
   Sao Paulo; Universidade Estadual de Campinas; Universidade de Sao Paulo;
   Universidade de Sao Paulo
RP Gualano, B (corresponding author), Univ Sao Paulo, Sch Phys Educ & Sport, Appl Physiol & Nutr Res Grp, Sao Paulo, SP, Brazil.; Gualano, B (corresponding author), Univ Sao Paulo, Hosp Clin HCFMUSP, Fac Med FMUSP, Ctr Lifestyle Med,Lab Assessment & Conditioning Rh, Ave Dr Arnaldo 455,3 Andar, BR-01246903 Sao Paulo, SP, Brazil.; Gualano, B (corresponding author), Univ Sao Paulo, Fac Med FMUSP, Rheumatol Div, Ave Dr Arnaldo 455, BR-05403900 Sao Paulo, SP, Brazil.
EM gualano@usp.br
RI Benatti, Fabiana/H-7167-2016; Gualano, Bruno/C-7190-2012; C. Mazzolani,
   Bruna/AAG-3126-2019; Guedes-Pinto, Ana/D-7995-2019; Romero,
   Marina/LSK-1117-2024; PASOTO, SANDRA/E-1213-2012; Mendes Sieczkowska,
   Sofia/N-1471-2017; Smaira, Fabiana/ADJ-2903-2022; Roschel,
   Hamilton/D-4353-2012
OI de Sa Pinto, Ana Lucia/0000-0001-5027-6521; Mendes Sieczkowska,
   Sofia/0000-0002-4869-318X; Smaira, Fabiana/0000-0003-4218-4779; Roschel,
   Hamilton/0000-0002-9513-6132
FU Sao Paulo Research Foundation - FAPESP [2019/15231-4, 2019/14820-6,
   2019/14819-8, 2017/13552-2]; Support fund to education, research and
   extension at the State University of Campinas - FAEPEX [519.292
   (98082-22)]; National Council for Scientific and Technological
   Development-CNPq [303116/2022-6]
FX S.M.S, B.C.M., F.I.S., and B.G. were supported by Sao Paulo Research
   Foundation - FAPESP (grants #2019/15231-4, # 2019/14820-6, #
   2019/14819-8 and #2017/13552-2),MR was supported by Support fund to
   education, research and extension at the State University of Campinas -
   FAEPEX accord 519.292 (98082-22) and SGP was supported by National
   Council for Scientific and Technological Development-CNPq
   (#303116/2022-6).
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NR 46
TC 1
Z9 1
U1 1
U2 7
PU SPRINGER LONDON LTD
PI LONDON
PA 236 GRAYS INN RD, 6TH FLOOR, LONDON WC1X 8HL, ENGLAND
SN 0770-3198
EI 1434-9949
J9 CLIN RHEUMATOL
JI Clin. Rheumatol.
PD MAR
PY 2024
VL 43
IS 3
BP 1003
EP 1013
DI 10.1007/s10067-024-06870-2
EA JAN 2024
PG 11
WC Rheumatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Rheumatology
GA IX2E6
UT WOS:001149224700001
PM 38280124
DA 2025-06-11
ER

PT J
AU Gholami, A
   Zamani, F
   Hosseini, B
   Sharafkhani, R
   Maadi, M
   Jahromi, ZM
   Khazaee-Pool, M
   Sohrabi, M
AF Gholami, Ali
   Zamani, Farhad
   Hosseini, Bayan
   Sharafkhani, Rahim
   Maadi, Mansooreh
   Jahromi, Zahra Moosavi
   Khazaee-Pool, Maryam
   Sohrabi, Masoudreza
TI Metabolic Syndrome Is Associated with Health-Related Quality of Life in
   Suspected Patients with Nonalcoholic Steatohepatitis
SO MEDICAL PRINCIPLES AND PRACTICE
LA English
DT Article
DE Metabolic syndrome; Nonalcoholic steatohepatitis; Quality of life;
   Twelve-Item Short-Form Health Survey
ID FATTY LIVER-DISEASE; HEPATIC STEATOSIS; VISCERAL FAT; EPIDEMIOLOGY;
   OBESITY
AB Objective: This study was designed to examine the effect of metabolic syndrome (MetS) on health-related quality of life (HRQOL) in patients with suspected nonalcoholic steatohepatitis (NASH). Subjects and Methods: Three hundred thirty-two patients (236 males and 96 females) with suspected NASH from the Amol cohort study were included in this study. MetS was diagnosed based on Adult Treatment Panel III criteria and HRQOL was measured using the 12-Item Short-Form Health Survey (SF-12) questionnaire (with 8 subscales and 2 summary components). A multivariable linear regression model was used to assess the independent effect of MetS on HRQOL. Results: The mean age of the study population was 42 +/- 13 years (range 18-82). The prevalence of MetS was 43.4% (n = 144) and the mean scores on the Physical Component Summary (PCS) and the Mental Component Summary were 72.4 +/- 20.86 and 42.7 +/- 12.42, respectively. The multivariable linear regression model showed that MetS was negatively associated with 4 subscales of HRQOL that included: role limitations due to physical problems (RP) (B = -14.05, p = 0.004), bodily pain (BP) (B = -7.37, p = 0.02), vitality (VT) (B = -7.72, p = 0.022), and role limitations due to emotional problems (RE) (B = -12.67, p = 0.005) after adjustment for other variables. Also, MetS had a borderline association with the general health and mental health subscales and the PCS (p < 0.1). Conclusion: In this study, there was a strong association between MetS and 4 subscales (RP, BP, VT, and RE) of HRQOL in patients with suspected NASH; this could be considered as a part of health policy to improve general health. (c) 2018 The Author(s) Published by S. Karger AG, Basel.
C1 [Gholami, Ali] Neyshabur Univ Med Sci, Sch Publ Hlth, Dept Publ Hlth, Neyshabur, Iran.
   Iran Univ Med Sci, Sch Publ Hlth, Dept Epidemiol, Tehran, Iran.
   [Gholami, Ali] Univ Tehran Med Sci, Noncommunicable Dis Res Ctr, Endocrinol & Metab Res Inst, Tehran, Iran.
   [Zamani, Farhad; Maadi, Mansooreh; Sohrabi, Masoudreza] Iran Univ Med Sci, Firoozgar Hosp, Gastrointestinal & Liver Dis Res Ctr, Tehran, Iran.
   [Hosseini, Bayan] Univ Tehran Med Sci, Sch Publ Hlth, Dept Epidemiol, Tehran, Iran.
   [Sharafkhani, Rahim] Khoy Univ Med Sci, Epidemiol, Khoy, Iran.
   [Jahromi, Zahra Moosavi] Iran Univ Med Sci, Hlth Management & Econ Res Ctr, Tehran, Iran.
   [Jahromi, Zahra Moosavi] Zabol Univ Med Sci, Sch Publ Hlth, Zabol, Iran.
   [Khazaee-Pool, Maryam] Zanjan Univ Med Sci, Sch Publ Hlth, Dept Hlth Educ & Promot, Zanjan, Iran.
C3 Iran University of Medical Sciences; Tehran University of Medical
   Sciences; Iran University of Medical Sciences; Tehran University of
   Medical Sciences; Iran University of Medical Sciences
RP Sohrabi, M (corresponding author), Beh Afarin Ave,Valiasr Sq, Tehran, Iran.
EM Sohrab_r@yahoo.com
RI Sharafkhani, Rahim/G-9050-2018; Zamani, Farhad/ABH-8503-2020; hosseini,
   Bayan/A-5026-2014; Gholami, Ali/I-1626-2018; Khazaee-Pool,
   Maryam/G-7193-2016
OI Gholami, Ali/0000-0003-0338-9368; Sohrabi,
   Masoudreza/0000-0001-5688-2776; Zamani, Farhad/0000-0001-7409-3412;
   Sharafkhani, Rahim/0000-0002-2666-322X; Hosseini,
   Bayan/0000-0003-2670-9133; Khazaee-Pool, Maryam/0000-0002-2587-3460
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TC 7
Z9 7
U1 0
U2 8
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1011-7571
EI 1423-0151
J9 MED PRIN PRACT
JI Med. Princ. Pract.
PY 2018
VL 27
IS 2
BP 166
EP 172
DI 10.1159/000487397
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA GE8VQ
UT WOS:000431509700011
PM 29402822
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Mieczkowska, J
   Mosiewicz, J
   Barud, W
   Kwasniewski, W
AF Mieczkowska, Jolanta
   Mosiewicz, Jerzy
   Barud, Wojciech
   Kwasniewski, Wojciech
TI Changes in the activity of connective tissue matrix enzymes in the
   metabolic syndrome
SO ARCHIVES OF MEDICAL SCIENCE
LA English
DT Article
DE metalloproteinase; tissue inhibitors of metalloproteinases; cytokines;
   metabolic syndrome; atherosclerosis
ID ACUTE CORONARY SYNDROMES; C-REACTIVE PROTEIN; METALLOPROTEINASE
   EXPRESSION; PROINFLAMMATORY CYTOKINES; CARDIOVASCULAR-DISEASE;
   CIRCULATING LEVELS; DIABETIC-PATIENTS; OXIDATIVE STRESS; ARTERY-DISEASE;
   PLASMA-LEVELS
AB Introduction: Early atherosclerotic changes in the endothelium associated with metabolic syndrome are generated with the participation of inflammatory cells, cytokines and enzymes of the extracellular matrix. The study is aimed at a comparison between the activity of inflammatory agents, tumour necrosis factor a (TNF-alpha) and the enzymes of the connective tissue matrix in the blood of healthy female patients as well as those suffering from the metabolic syndrome.
   Material and methods: The examination included 35 women with metabolic syndrome (MS). The control group (C) comprised 35 healthy women. Lipidogram, C-reactive protein level (CRP), fasting glucose level (FGL), matrix metalloproteinase (MMP)-8 and -9 activity, tissue inhibitor of metalloproteinase-1 (TIMP-1) and TNF-alpha levels in blood were determined.
   Results: As compared with the control group, the level of inflammatory factors and the activity of extracellular matrix enzymes in the metabolic syndrome were statistically higher (p < 0.05) and concerned the following parameters: TNF-alpha (pg/ml): MS 6.59 +/- 3.18, C 4.78 +/- 2.91; CRP (mg/di): MS 2.18 +/- 2.04, C 1,26 +/- 1.35; TIMP-1 (ng/m1): MS 265.5 +/- 2.9, C 205.4 +/- 72.6; MMP-9 (ng/ml): MS 198.2 +/- 138.6, C 138.6 +/- 116.1. Statistically significant correlations were also found between TIMP-1 and the following factors: BMI (R = 0.400, p < 0.001), waist/hip ratio (WHR) (R = 0.278, p < 0.05), waistline (R = 0.417, p < 0.001), FGL (R = 0.290, p < 0.05), HDL cholesterol (R = -0.253, p < 0.05) and triglycerides (R = 0.269, p < 0.05). There were positive correlations of MMP-9 with FGL (R = 0.446, p < 0.001) and waistline (R = 0.260, p < 0.05); MMP-8 with FGL (R = 0.308, p < 0.05); and CRP with BMI (R = 0.370, p < 0.01), WHR (R = 0.325, p < 0.01) and waistline (R = 0.368, p < 0.01).
   Conclusions: Metabolic syndrome is connected with higher activity of cytokines (TNF-alpha), inflammatory markers (CRP) and matrix enzymes (MMP-9, MMP-8, TIM P-1).
C1 [Mieczkowska, Jolanta; Mosiewicz, Jerzy; Barud, Wojciech] Med Univ Lublin, Chair Internal Med, PL-20081 Lublin, Poland.
   [Mieczkowska, Jolanta; Mosiewicz, Jerzy; Barud, Wojciech] Med Univ Lublin, Dept Internal Med, PL-20081 Lublin, Poland.
   [Kwasniewski, Wojciech] Med Univ Lublin, Students Sci Assoc Dept, PL-20081 Lublin, Poland.
C3 Medical University of Lublin; Medical University of Lublin; Medical
   University of Lublin
RP Mieczkowska, J (corresponding author), Med Univ Lublin, Chair Internal Med, SPSK 1,16 Stasz, PL-20081 Lublin, Poland.
EM jo.mie@poczta.onet.pl
OI Mosiewicz, Jerzy/0000-0003-0320-1863
FU University of Lublin [159/07]
FX This work was supported by a grant of the University of Lublin (159/07).
   We hereby thank the university for the grant.
CR [Anonymous], 2005, IDF CONS WORLDW DEF
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NR 35
TC 16
Z9 18
U1 0
U2 4
PU TERMEDIA PUBLISHING HOUSE LTD
PI POZNAN
PA WENEDOW ST 9-1, POZNAN, 61-614, POLAND
SN 1734-1922
J9 ARCH MED SCI
JI Arch. Med. Sci.
PD AUG
PY 2011
VL 7
IS 4
BP 634
EP 641
DI 10.5114/aoms.2011.24133
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 821QA
UT WOS:000294988300016
PM 22291799
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Hambly, R
   Kearney, N
   Hughes, R
   Fletcher, JM
   Kirby, B
AF Hambly, Roisin
   Kearney, Niamh
   Hughes, Rosalind
   Fletcher, Jean M.
   Kirby, Brian
TI Metformin Treatment of Hidradenitis Suppurativa: Effect on Metabolic
   Parameters, Inflammation, Cardiovascular Risk Biomarkers, and Immune
   Mediators
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE hidradenitis suppurativa; HS; metformin; insulin resistance;
   cardiovascular risk; adipokines; CRP; metabolic syndrome
ID POLYCYSTIC-OVARY-SYNDROME; TYPE-2 DIABETES-MELLITUS; ACTIVATED
   PROTEIN-KINASE; C-REACTIVE PROTEIN; T-HELPER 17; INSULIN-RESISTANCE;
   WAIST CIRCUMFERENCE; WEIGHT-LOSS; ASSOCIATION; PREVALENCE
AB Hidradenitis suppurativa (HS) is a common cutaneous and systemic inflammatory disease with a significant impact on mental health and quality of life. It is associated with obesity, insulin resistance, metabolic syndrome, cardiovascular (CV) disease, and increased all-cause mortality. Metformin is used frequently in HS treatment and is effective for some patients. The mechanism of action of metformin in HS is unknown. A case-control study of 40 patients with HS (20 on metformin and 20 controls) was conducted to assess differences in metabolic markers, inflammation (C-reactive protein [CRP], serum adipokines, and CV risk biomarkers), and serum immune mediators. Body mass index (BMI), insulin resistance (77%), and metabolic syndrome (44%) were high overall, but not significantly different between the groups. This highlights the need for co-morbidity screening and management. A significant reduction in fasting insulin and a trend towards a reduction in insulin resistance were identified in the metformin group compared with pre-treatment levels. CV risk biomarkers were significantly favourable in the metformin group (lymphocytes, monocyte-lymphocyte ratio, neutrophil-lymphocyte ratio, and platelet-lymphocyte ratio). CRP was lower in the metformin group but was not statistically significant. Adipokines were dysregulated overall but were not different between the two groups. Serum IFN-gamma, IL-8, TNF-alpha, and CXCL1 trended lower in the metformin group but did not reach significance. These results suggest that metformin improves CV risk biomarkers and insulin resistance in patients with HS. When the results of this study are considered alongside other studies in HS and related conditions, it is likely that metformin also has beneficial effects on metabolic markers and systemic inflammation in HS (CRP, serum adipokines, and immune mediators), warranting further research.
C1 [Hambly, Roisin; Kearney, Niamh; Hughes, Rosalind; Kirby, Brian] St Vincents Univ Hosp, Charles Ctr, Dept Dermatol, Dublin D04T6F4, Ireland.
   [Hambly, Roisin; Kearney, Niamh; Kirby, Brian] Univ Coll Dublin, Charles Inst Dermatol, Sch Med, Dublin D04V1W8, Ireland.
   [Fletcher, Jean M.] Trinity Coll Dublin, Trinity Biomed Sci Inst, Sch Biochem & Immunol, Dublin D02R590, Ireland.
   [Fletcher, Jean M.] Trinity Coll Dublin, Trinity Biomed Sci Inst, Sch Med, Dublin D02R590, Ireland.
C3 University College Dublin; Saint Vincent's University Hospital;
   University College Dublin; Trinity College Dublin; Trinity College
   Dublin
RP Hambly, R (corresponding author), St Vincents Univ Hosp, Charles Ctr, Dept Dermatol, Dublin D04T6F4, Ireland.; Hambly, R (corresponding author), Univ Coll Dublin, Charles Inst Dermatol, Sch Med, Dublin D04V1W8, Ireland.
EM roisinhambly@gmail.com
RI Kearney, Niamh/AAJ-6737-2020; Fletcher, Jean/I-2289-2019; Hambly,
   Roisin/HII-2892-2022
OI Fletcher, Jean/0000-0002-0670-6659; Hambly, Roisin/0000-0002-7050-738X;
   Kearney, Niamh/0000-0002-6469-3462
FU Wellcome Trust; Health Research Board Ireland [203930/B/16/Z]
FX RH (Roisin Hambly) was supported by an academic training grant under the
   Irish Clinical Academic Training Programme, supported by the Wellcome
   Trust and the Health Research Board Ireland (Grant Number
   203930/B/16/Z).
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NR 120
TC 16
Z9 16
U1 0
U2 3
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD APR
PY 2023
VL 24
IS 8
AR 6969
DI 10.3390/ijms24086969
PG 19
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA F0DB4
UT WOS:000979128800001
PM 37108132
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Kassaw, AB
   Endale, HT
   Tesfa, KH
   Molla, MD
AF Kassaw, Altaseb Beyene
   Endale, Hiwot Tezera
   Tesfa, Kibur Hunie
   Molla, Meseret Derbew
TI Metabolic syndrome and its associated factors among epileptic patients
   at Dessie Comprehensive Specialized Hospital, Northeast Ethiopia; a
   hospital-based comparative cross-sectional study
SO PLOS ONE
LA English
DT Article
ID ANTIEPILEPTIC DRUGS; VALPROIC ACID; ADULTS; DEFINITION; CHILDREN;
   MARKERS; STRESS
AB Introduction Metabolic syndrome is a group of metabolic risk factors which are associated with an increased risk of cardiovascular disease and type2 diabetes. Nowadays, several studies have shown that the burden of metabolic syndrome is increasing among epileptic patients, and leads to MS-associated complications, including cardiovascular disease. However, getting published documents has been limited in Ethiopia and the study area. Therefore, we aimed to analyze the magnitude and associated factors of metabolic syndrome among epileptic patients in Dessie Comprehensive Specialized Hospital in compression with respective controls.
   Methods Hospital-based comparative cross-sectional study design was implemented from June 25 to August 20, 2021. A total of 204 participants with an equal number of cases and controls (n = 102 each) were included. The data was collected through face-to-face interviews and biochemical analyses such as fasting blood glucose and lipid profiles were done through the enzymatic technique. The magnitude of metabolic syndrome was determined using both National Cholesterol Education Program Adult Treatment Panel III and International Diabetes Federation definition criteria. The STATA version 14 was used for statistical data analysis, and a comparison of categorical and continuous variables was done with chi(2) and an independent t-test, respectively. The multivariable binary logistic regression analysis was used to identify factors associated with metabolic syndrome, and variables having a P-value of <0.05 were considered statistically significant.
   Result The prevalence of metabolic syndrome among the epileptic group was (25.5% in National Cholesterol Education Program Adult Treatment Panel III and 23.5% in International Diabetes Federation criteria), whereas it was 13.7% in National Cholesterol Education Program Adult Treatment Panel III and 14.7% in International Diabetes Federation criteria among control groups. According to the International Diabetes Federation criteria, low physical activity (adjusted odds ratio = 4.73, 95% CI: 1.08-20.68), taking multiple antiepileptic drugs (adjusted odds ratio = 8.08, 95% CI: 1.52-42.74), having a total cholesterol level of >= 200 mg/dl (adjusted odds ratio = 5.81, 95%: 1.32-41.13) and body mass index (adjusted odds ratio = 1.57, 95% CI = 1.16-2.11) were significantly associated with metabolic syndrome among epileptic participants. Applying National Cholesterol Education Program Adult Treatment Panel III criteria, taking multiple antiepileptic drugs (adjusted odds ratio = 6.81, 95% CI: 1.29-35.92), having a total cholesterol level > 200 mg/dl (adjusted odds ratio = 7.37, 95% CI: 1.32-41.13) and body mass index (adjusted odds ratio = 1.53, 96% CI: 1.16-2.01) were also significantly associated.
   Conclusion The prevalence of metabolic syndrome among epileptic patients was higher than that of control groups and reaches statistically significant by National Cholesterol Education Program Adult Treatment Panel III. Being on multiple antiepileptic drugs, body mass index, having low physical activity and raised total cholesterol were significantly associated with metabolic syndrome among the epileptic group. Therefore, it is better to focus on controlling weight, having sufficient physical exercise, and regular monitoring of total cholesterol levels in epileptic patients.
C1 [Kassaw, Altaseb Beyene] Wollo Univ, Coll Med & Hlth Sci, Sch Med, Dept Biomed Sci, Dessie, Ethiopia.
   [Endale, Hiwot Tezera; Tesfa, Kibur Hunie; Molla, Meseret Derbew] Univ Gondar, Coll Med & Hlth Sci, Sch Med, Dept Biomed Sci, Gondar, Ethiopia.
C3 University of Gondar
RP Kassaw, AB (corresponding author), Wollo Univ, Coll Med & Hlth Sci, Sch Med, Dept Biomed Sci, Dessie, Ethiopia.
EM altasebbeyene7@gmail.com
RI Hunie Tesfa, Kibur/MXK-7137-2025; Endale, Hiwot/MVU-1625-2025; Molla,
   Meseret/ABB-1928-2020
OI beyene, altaseb/0000-0001-6359-7826; Endale, Hiwot/0000-0002-4672-0551;
   Molla, Meseret Derbew/0000-0002-2622-522X
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NR 49
TC 4
Z9 4
U1 1
U2 2
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD DEC 29
PY 2022
VL 17
IS 12
AR e0279580
DI 10.1371/journal.pone.0279580
PG 19
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 8O4LO
UT WOS:000925807400030
PM 36580471
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Fu, KQ
   Wang, JL
   Pan, HJ
   Huang, L
   Li, XL
AF Fu, Keqi
   Wang, Jiale
   Pan, Hejing
   Huang, Lin
   Li, Xuanlin
TI Weekend warrior and the risk of specific disease: a meta-epidemiology
   study
SO BMC PUBLIC HEALTH
LA English
DT Review
DE Weekend warrior; Meta-analysis; Observational study; Mortality;
   Neurological disorder; Cardiovascular outcome
ID PHYSICAL-ACTIVITY PATTERNS; ASSOCIATION; MORTALITY
AB BackgroundThe "Weekend Warrior (WW)" physical activity (PA) pattern, involving intensive exercise on 1-2 days per week, has become increasingly popular. The WW PA pattern demonstrates protective effects against a broad spectrum of chronic diseases; however, regarding a comprehensive investigation into the disease-specific protective mechanisms and long-term health outcomes of the subject, it remains unclear. WW exhibits protective effects against various diseases; however, there is a conspicuous scarcity of literature investigating its protective mechanisms across different disease conditions. The objective of this meta-epidemiology study was to exam WW's protective effects by synthesizing data from published observational studies.MethodsA systematic search was conducted across databases including PubMed, Embase, Cochrane Library and Web of Science through February 19, 2025. The search focused on observational studies reporting the association between the WW PA pattern and various health outcomes, including cardiovascular diseases, mortality, metabolic syndrome, and mental health, compared to inactive individuals. Odds ratios (ORs) were pooled using random-effects models. Subgroup analyses were performed to investigate the association with ORs of factors, such as sex, study type, and PA assessment.ResultsTwenty-seven studies encompassing 1,204,486 participants were included. The pooled analysis indicated that the WW exercise pattern significantly reduced the risk of CVD mortality (OR = 0.742, 95% CI: 0.568-0.968), I2 = 71.3%, P = 0.028). Additionally, WW showed lower risks of mental disorders and metabolic syndrome.ConclusionThe WW PA pattern is associated with significant health benefits, including reduced risks of mortality, cardiovascular diseases, and metabolic syndrome. This pattern may be a viable alternative for individuals unable to engage in daily physical activity. Future research should further explore the long-term effects and refine exercise recommendations for various population subgroups.PROSPERO registration numberCRD42024587216.
C1 [Fu, Keqi] Zhejiang Chinese Med Univ, Dept Publ Phys, Hangzhou, Peoples R China.
   [Wang, Jiale] Chinese Med Univ, Clin Med Coll Zhejiang 1, Hangzhou, Peoples R China.
   [Pan, Hejing; Huang, Lin; Li, Xuanlin] Zhejiang Chinese Med Univ, Coll Basic Med Sci, Hangzhou, Peoples R China.
   [Huang, Lin; Li, Xuanlin] Zhejiang Chinese Med Univ, Key Lab Chinese Med Rheumatol Zhejiang Prov, 548 Binwen Rd, Hangzhou 310053, Peoples R China.
C3 Zhejiang Chinese Medical University; China Medical University; Zhejiang
   Chinese Medical University; Zhejiang Chinese Medical University
RP Li, XL (corresponding author), Zhejiang Chinese Med Univ, Coll Basic Med Sci, Hangzhou, Peoples R China.; Li, XL (corresponding author), Zhejiang Chinese Med Univ, Key Lab Chinese Med Rheumatol Zhejiang Prov, 548 Binwen Rd, Hangzhou 310053, Peoples R China.
EM lixuanlinhnzy@163.com
FU Academician Matching Program [361100E002]; Research Project of Zhejiang
   Chinese Medical University [2023 JKZKTS27]
FX This study was funded by grant 361100E002 from the Academician Matching
   Program; and grant 2023 JKZKTS27 from the Research Project of Zhejiang
   Chinese Medical University.
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NR 36
TC 0
Z9 0
U1 1
U2 1
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2458
J9 BMC PUBLIC HEALTH
JI BMC Public Health
PD APR 15
PY 2025
VL 25
IS 1
AR 1414
DI 10.1186/s12889-025-22667-7
PG 20
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA 1MJ5E
UT WOS:001468455800007
PM 40234866
DA 2025-06-11
ER

PT J
AU Seabra, A
   Katzmarzyk, P
   Carvalho, MJ
   Seabra, A
   Coelho-E-Silva, M
   Abreu, S
   Vale, S
   Póvoas, S
   Nascimento, H
   Belo, L
   Torres, S
   Oliveira, J
   Mota, J
   Santos-Silva, A
   Rêgo, C
   Malina, RM
AF Seabra, Andre
   Katzmarzyk, Peter
   Carvalho, Maria Jose
   Seabra, Ana
   Coelho-E-Silva, Manuel
   Abreu, Sandra
   Vale, Susana
   Povoas, Susana
   Nascimento, Henrique
   Belo, Luis
   Torres, Sandra
   Oliveira, Jose
   Mota, Jorge
   Santos-Silva, Alice
   Rego, Carla
   Malina, Robert M.
TI Effects of 6-month soccer and traditional physical activity programmes
   on body composition, cardiometabolic risk factors, inflammatory,
   oxidative stress markers and cardiorespiratory fitness in obese boys
SO JOURNAL OF SPORTS SCIENCES
LA English
DT Article
DE Activity intervention; weight status; risk factors; youth; sport
ID BONE-MINERAL DENSITY; RECREATIONAL FOOTBALL; PORTUGUESE POPULATION;
   CHILDRENS ATTRACTION; MAJOR DETERMINANTS; DANISH CHILDREN; TEAM SPORTS;
   OVERWEIGHT; COMPETENCE; VALIDATION
AB Physical activity is important in obesity prevention, but the effectiveness of different physical activity modalities remains to be determined among children. The main purpose of this study was to compare the effects of a 6-month soccer programme and a traditional physical activity programme on changes in body composition, cardiometabolic risk factors, inflammatory and oxidative markers, cardiorespiratory fitness and perceived psychological status in obese boys. Eighty-eight boys (8-12years; BMI > +2 standard deviations of WHO reference values) participated in one of three groups: soccer, traditional activity and control. Soccer and traditional activity programmes involved 3 sessions per week for 60-90min at an average intensity of 70-80% of maximal heart rate. Control group participated in activities of normal daily living. All boys participated in school physical education, two sessions per week of 45-90-min. Measurements were taken at baseline and after 6months, and included body size and composition, cardiometabolic risk factors, inflammatory and oxidative markers, cardiorespiratory fitness and perceived psychological status. Physical activity and dietary intake were assessed before and immediately following the intervention. The three groups had similar characteristics at baseline. After 6months, both intervention groups had significantly lower relative fatness (% fat), waist circumference and total cholesterol, and higher cardiorespiratory fitness, self-esteem, perceived physical competence and attraction to physical activity compared with control group. In conclusion, physical activity interventions over 6months positively influenced several indicators of health status among obese boys. The results also suggested that soccer has the potential as an effective tool for the prevention and reduction of childhood obesity and associated consequences.
C1 [Seabra, Andre; Seabra, Ana; Abreu, Sandra; Vale, Susana; Oliveira, Jose; Mota, Jorge] Univ Porto, Fac Sport, Res Ctr Phys Act Hlth & Leisure CIAFEL, Porto, Portugal.
   [Katzmarzyk, Peter] Louisiana State Univ Syst, Pennington Biomed Res Ctr, Baton Rouge, LA USA.
   [Carvalho, Maria Jose] Univ Porto, Fac Sport, Ctr Res Educ Innovat & Intervent Sport CIFI2D, Porto, Portugal.
   [Coelho-E-Silva, Manuel] Univ Coimbra, Fac Sport Sci & Phys Educ, Coimbra, Portugal.
   [Povoas, Susana] ISMAI, Univ Inst Maia, CIDESD, Res Ctr Sports Sci Hlth Sci & Human Dev, Maia, Portugal.
   [Nascimento, Henrique; Belo, Luis; Santos-Silva, Alice] Univ Porto, Dept Biol Sci, Fac Pharm, Porto, Portugal.
   [Nascimento, Henrique; Belo, Luis; Santos-Silva, Alice] Univ Porto, Inst Mol & Cell Biol, Porto, Portugal.
   [Torres, Sandra] Univ Porto, Fac Psychol & Educ Sci, Porto, Portugal.
   [Rego, Carla] Univ Porto, Ctr Res Hlth Technol & Informat Syst, Fac Med, Porto, Portugal.
   [Malina, Robert M.] Univ Texas Austin, Dept Kinesiol & Hlth Educ, Austin, TX 78712 USA.
   [Vale, Susana] Polytech Inst Porto, High Sch Educ, Dept Sport Sci, Porto, Portugal.
C3 Universidade do Porto; Louisiana State University System; Louisiana
   State University; Pennington Biomedical Research Center; Universidade do
   Porto; Universidade de Coimbra; Instituto Universitario da Maia (ISMAI);
   Universidade do Porto; Universidade do Porto; Universidade do Porto;
   Universidade do Porto; University of Texas System; University of Texas
   Austin; Instituto Politecnico do Porto
RP Seabra, A (corresponding author), Univ Porto, Fac Sport, Rua Dr Placido Costa 91, P-4200 Porto, Portugal.
EM aseabra@fade.up.pt
RI Torres, Sandra/L-4688-2019; Santos-Silva, Alice/AAC-7082-2020; Abreu,
   Sandra/L-7547-2013; Malina, Robert/NAZ-7621-2025; Vale,
   Susana/L-8367-2013; Póvoas, Susana/R-1165-2018; Katzmarzyk,
   Peter/N-1974-2017; Belo, Luis/K-5878-2013; Seabra, Andre/L-8770-2013;
   Santos-Silva, Alice/K-2326-2013; Oliveira, Jose/D-2303-2009; mota,
   jorge/B-2980-2013; Coelho-e-Silva, Manuel/O-2604-2019
OI Katzmarzyk, Peter/0000-0002-9280-6022; Belo, Luis/0000-0002-3941-6850;
   Torres, Sandra/0000-0003-4526-4272; Seabra, Andre/0000-0002-6788-4555;
   Carvalho, Maria Jose/0000-0002-4975-0115; Santos-Silva,
   Alice/0000-0002-2565-3169; Oliveira, Jose/0000-0002-1829-4196; mota,
   jorge/0000-0001-7571-9181; Coelho-e-Silva, Manuel/0000-0003-4512-7331;
   Abreu, Sandra/0000-0002-6722-1575; Vale, Susana/0000-0002-1703-9361;
   Povoas, Susana/0000-0002-6661-3673
FU Union European Football Association (UEFA); Portuguese Football
   Federation (FPF); Portuguese Foundation for Science and Technology
   [UID/DTP/00617/2013]
FX This study was supported by the Union European Football Association
   (UEFA) and Portuguese Football Federation (FPF). The Research Center in
   Physical Activity, Health and Leisure (CIAFEL) is funded by the
   Portuguese Foundation for Science and Technology (UID/DTP/00617/2013).
CR [Anonymous], 2008, 2008 physical activity guidelines for Americans
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NR 46
TC 57
Z9 63
U1 1
U2 95
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0264-0414
EI 1466-447X
J9 J SPORT SCI
JI J. Sports Sci.
PD OCT
PY 2016
VL 34
IS 19
BP 1822
EP 1829
DI 10.1080/02640414.2016.1140219
PG 8
WC Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Sport Sciences
GA DR8QP
UT WOS:000380162700005
PM 26890580
DA 2025-06-11
ER

PT J
AU Blaslov, K
   Kruljac, I
   Mirosevic, G
   Bilos, LSK
   Vrkljan, M
AF Blaslov, K.
   Kruljac, I.
   Mirosevic, G.
   Bilos, Lora S. Kirigin
   Vrkljan, M.
TI The possible role of stress induced hormonal disbalance in the
   patophysiology of insulin resistane in lean individuals
SO MEDICAL HYPOTHESES
LA English
DT Article
DE Insulin resistance; Hypothalamic-pituitaryadrenal axis; Stress;
   Depression
ID METABOLIC SYNDROME; MAJOR DEPRESSION; HUMAN-DISEASE; HPA AXIS;
   PATHOPHYSIOLOGY; INFLAMMATION; CYTOKINES; MUSCLE
AB Insulin resistance (IR) is a common denominator of metabolic and hemodynamic disorders simultaneously present in one person and responsible for elevated risk of developing type 2 diabetes (T2DM) and cardiovascular incidents. According to the latest research, IR is present in 25-45% of the general population. Therefore, the mechanism of its development is in the center of scientific and professional interest. Established or acquired factors, or combinations thereof, which disturb any step of the physiological insulin action mechanism: its binding to the cellular receptor, through the complex cascade of intracellular signaling pathways might cause IR. Although the adiposity and its underlying risk factors are considered to be the primary cause of IR, it is present in a great porportion in lean individuals as well.
   There are insights of the possible role of psychological factors: exposure to stress and deprssion to IR development, although the mechanism of this relationship has not been comperhensively studied. Data driven from cell cultures and experimental animal models suggest that there is an elevated level of counter-regulatory insulin hormones: growth hormone, prolactin and cortisol due to acute stress exposure. However, the relationship between these psychological disorders with the hyperreactivity of the axis of the hypothalamic-pituitaryadrenal axis as the underlying mechanism in the patophysiology of IR in lean individuals has not been systematically investigated. Based on the aforementioned, we hypothesise that this mechanism would be responsible for the formation of IR, and consequently, T2DM in lean individuals.
   The possible effect of the amount of stress in conjunction with the serum concentration of growth hormone, cortisol, prolactin and dehydroepiandrostendone to the abnormal 5-h oral glucose tollerance test results could contribute to the primary prevention of diabetes and its complications.
C1 [Blaslov, K.; Kruljac, I.; Mirosevic, G.; Bilos, Lora S. Kirigin; Vrkljan, M.] Univ Hosp Ctr Sestre Milosrdnice, Dept Endocrinol Diabet & Metab Dis Mladen Sekso, Vinogradska Cesta 29, HR-10000 Zagreb, Croatia.
   [Blaslov, K.; Kruljac, I.; Vrkljan, M.] Univ Zagreb, Sch Med, Zagreb, Croatia.
C3 University of Zagreb
RP Blaslov, K (corresponding author), Univ Hosp Ctr Sestre Milosrdnice, Dept Endocrinol Diabet & Metab Dis Mladen Sekso, Vinogradska Cesta 29, HR-10000 Zagreb, Croatia.
EM kblaslov@gmail.com
RI Mirosevic, Gorana/AAK-9294-2021
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NR 22
TC 4
Z9 4
U1 0
U2 4
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0306-9877
EI 1532-2777
J9 MED HYPOTHESES
JI Med. Hypotheses
PD MAY
PY 2018
VL 114
BP 8
EP 10
DI 10.1016/j.mehy.2018.02.032
PG 3
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA GD5CW
UT WOS:000430523600003
PM 29602470
DA 2025-06-11
ER

PT J
AU Turra, CM
   Goldman, N
   Seplaki, CL
   Glei, DA
   Lin, YH
   Weinstein, M
AF Turra, CM
   Goldman, N
   Seplaki, CL
   Glei, DA
   Lin, YH
   Weinstein, M
TI Determinants of mortality at older ages: The role of biological markers
   of chronic disease
SO POPULATION AND DEVELOPMENT REVIEW
LA English
DT Article
ID CORONARY-HEART-DISEASE; NUTRITION EXAMINATION SURVEY; ALL-CAUSE
   MORTALITY; SELF-RATED HEALTH; BODY-MASS INDEX; BLOOD-PRESSURE;
   RISK-FACTORS; SOCIAL RELATIONSHIPS; SOCIOECONOMIC DIFFERENCES;
   ALLOSTATIC LOAD
AB Researchers have had a longstanding interest in understanding the determinants of mortality. This article examines the impact of a broad array of biological markers, together With self-reports of physical and mental health status, on the probability of dying for older adults. The estimates are derived from logistic regression models based on data from a national survey in Taiwan. The analysis confirms previous studies demonstrating the effects of clinical measures related to metabolic syndrome on mortality and identifies detrimental effects of neuroendocrine and immune-system markers. The results reveal that biomarkers provide independent explanatory power in the presence of self-reported health measures. The associations between biomarkers and mortality found here provide new avenues for projecting future mortality and elucidating differences in longevity across populations.
C1 Princeton Univ, Off Populat Res, Princeton, NJ 08544 USA.
   Princeton Univ, Ctr Hlth & Wellbeing, Princeton, NJ 08544 USA.
   Univ Fed Minas Gerais, Belo Horizonte, MG, Brazil.
   Johns Hopkins Univ, Ctr Aging & Hlth, Baltimore, MD 21218 USA.
   Johns Hopkins Univ, Dept Populat & Family Hlth Sci, Baltimore, MD 21218 USA.
   Univ Calif Berkeley, Dept Demog, Berkeley, CA 94720 USA.
   Georgetown Univ, Ctr Populat & Hlth, Washington, DC 20057 USA.
C3 Princeton University; Princeton University; Universidade Federal de
   Minas Gerais; Johns Hopkins University; Johns Hopkins University;
   University of California System; University of California Berkeley;
   Georgetown University
RP Princeton Univ, Off Populat Res, Princeton, NJ 08544 USA.
RI Turra, Cassio/K-2393-2019
OI Goldman, Noreen/0000-0003-2865-9491; Seplaki,
   Christopher/0000-0001-8296-7714; Turra, Cassio/0000-0003-4051-3567
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NR 78
TC 23
Z9 28
U1 0
U2 11
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0098-7921
EI 1728-4457
J9 POPUL DEV REV
JI Popul. Dev. Rev.
PD DEC
PY 2005
VL 31
IS 4
BP 675
EP +
DI 10.1111/j.1728-4457.2005.00093.x
PG 25
WC Demography; Sociology
WE Social Science Citation Index (SSCI)
SC Demography; Sociology
GA 000VJ
UT WOS:000234490200003
OA Bronze
DA 2025-06-11
ER

PT J
AU Moody, DLB
   Chang, YF
   Brown, C
   Bromberger, JT
   Matthews, KA
AF Moody, Danielle L. Beatty
   Chang, Yuefang
   Brown, Charlotte
   Bromberger, Joyce T.
   Matthews, Karen A.
TI Everyday Discrimination and Metabolic Syndrome Incidence in a
   Racially/Ethnically Diverse Sample: Study of Women's Health Across the
   Nation
SO PSYCHOSOMATIC MEDICINE
LA English
DT Article
DE everyday discrimination; longitudinal; race; ethnicity; metabolic
   syndrome incidence
ID SELF-REPORTED EXPERIENCES; AFRICAN-AMERICAN WOMEN; BODY-MASS INDEX;
   PERCEIVED DISCRIMINATION; CARDIOVASCULAR-DISEASE; DEPRESSIVE SYMPTOMS;
   WAIST CIRCUMFERENCE; UNFAIR TREATMENT; BLOOD-PRESSURE; MENTAL-HEALTH
AB Objective Everyday discrimination may contribute to incident metabolic syndrome (MetS) in the United States and related racial/ethnic differences in MetS. The study investigated whether everyday discrimination predicted MetS in a diverse sample.
   Methods A longitudinal, cohort study of 2132 women (mean [standard deviation] = 45.8 [2.7] years) who self-reported as black (n = 523), white (n = 1065), Chinese (n = 194), Japanese (n = 227), or Hispanic (n = 123) at baseline drawn from seven cities across the United States was conducted. MetS was defined in accordance with the National Cholesterol Education Program Adult Treatment Panel III criteria. The Everyday Discrimination scale was used to assess exposure to and level of everyday discrimination.
   Results Everyday discrimination exposure at baseline predicted a 33% greater incidence of MetS during the 13.89-year (standard deviation = 3.83, hazard ratio (HR) = 1.33, 95% confidence interval [CI] = 1.11-1.64, p = .001) follow-up in the full sample and was most pronounced in black, Hispanic, and Japanese women. Each 1-point increase in the continuous everyday discrimination score (HR = 1.03, 95% CI =1.01-1.05, p = .001) predicted a 3% greater incidence of MetS and, specifically, blood pressure (HR = 1.01, 95% CI = 1.00-1.03, p = .04), waist circumference (HR = 1.05, 95% CI =1.03-1.06, p < .001), and triglyceride level (HR = 1.02, 95% CI =1.00-1.04, p = .01). These associations were independent of risk factors including physical activity, socioeconomic status, smoking, and alcohol consumption.
   Conclusions Everyday discrimination contributes to poorer metabolic health in midlife women in the United States. These findings have clinical implications for the development of MetS and, ultimately, cardiovascular disease and diabetes, and intervention strategies to reduce these outcomes.
C1 [Moody, Danielle L. Beatty] Univ Maryland Baltimore Cty, Dept Psychol, Baltimore, MD 21228 USA.
   [Chang, Yuefang] Univ Pittsburgh, Dept Neurosurg, Pittsburgh, PA USA.
   [Brown, Charlotte; Bromberger, Joyce T.; Matthews, Karen A.] Univ Pittsburgh, Dept Psychiat, Pittsburgh, PA USA.
   [Bromberger, Joyce T.; Matthews, Karen A.] Univ Pittsburgh, Dept Epidemiol, Pittsburgh, PA 15261 USA.
   [Matthews, Karen A.] Univ Pittsburgh, Dept Psychol, Pittsburgh, PA 15260 USA.
C3 University System of Maryland; University of Maryland Baltimore County;
   Pennsylvania Commonwealth System of Higher Education (PCSHE); University
   of Pittsburgh; Pennsylvania Commonwealth System of Higher Education
   (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of
   Higher Education (PCSHE); University of Pittsburgh; Pennsylvania
   Commonwealth System of Higher Education (PCSHE); University of
   Pittsburgh
RP Moody, DLB (corresponding author), Univ Maryland Baltimore Cty, Dept Psychol, Human Serv Psychol, Behav Med & Community Psychol Subprogram, 1000 Hilltop Circle,Math Psychol Bldg,Off 328, Baltimore, MD 21250 USA.
EM dlbeatty@umbc.edu
FU National Institutes of Health (NIH), Department of Health and Human
   Services, through the National Institute on Aging, the National
   Institute of Nursing Research; NIH Office of Research on Women's Health
   [U01NR004061, U01AG012505, U01AG012535, U01AG012531, U01AG012539,
   U01AG012546, U01AG012553, U01AG012554, U01AG012495]; SWAN Repository
   [U01AG017719]; NIH [K01AG043581]; National Center for Research
   Resources; National Center for Advancing Translational Sciences, NIH,
   through UCSF-CTSI Grant [UL1 RR024131]
FX SWAN has grant support from the National Institutes of Health (NIH),
   Department of Health and Human Services, through the National Institute
   on Aging, the National Institute of Nursing Research, and the NIH Office
   of Research on Women's Health (Grants U01NR004061; U01AG012505,
   U01AG012535, U01AG012531, U01AG012539, U01AG012546, U01AG012553,
   U01AG012554, and U01AG012495). Additional sources of support are from
   the SWAN Repository (U01AG017719), and Danielle L. Beatty Moody has
   grant support via NIH (K01AG043581). This publication also was supported
   in part by the National Center for Research Resources and the National
   Center for Advancing Translational Sciences, NIH, through UCSF-CTSI
   Grant No. UL1 RR024131. The content of this article is solely the
   responsibility of the authors and does not necessarily represent the
   official views of the National Institute on Aging, National Institute of
   Nursing Research, Office of Research on Women's Health, or the NIH.
   There were no conflicts of interest for authors involved in the
   development of this article.
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NR 38
TC 37
Z9 49
U1 0
U2 12
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0033-3174
EI 1534-7796
J9 PSYCHOSOM MED
JI Psychosom. Med.
PD JAN
PY 2018
VL 80
IS 1
BP 114
EP 121
DI 10.1097/PSY.0000000000000516
PG 8
WC Psychiatry; Psychology; Psychology, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry; Psychology
GA FS2WD
UT WOS:000419639100019
PM 28787363
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Aboukhoudir, F
   Philouze, C
   Grandperrin, A
   Nottin, S
   Obert, P
AF Aboukhoudir, Falah
   Philouze, Clothilde
   Grandperrin, Antoine
   Nottin, Stephane
   Obert, Philippe
TI Additive effects of type 2 diabetes and metabolic syndrome on left
   ventricular torsion and linear deformation abnormalities during
   dobutamine stress echocardiography
SO FRONTIERS IN CARDIOVASCULAR MEDICINE
LA English
DT Article
DE uncomplicated type 2 diabetes; metabolic syndrome; asymptomatic
   patients; dobutamine stress echocardiography; speckle-tracking imaging;
   twist-untwist mechanics
ID SPECKLE-TRACKING ECHOCARDIOGRAPHY; EPICARDIAL ADIPOSE-TISSUE; TWIST
   MECHANICS; MYOCARDIAL DYSFUNCTION; EXERCISE INTOLERANCE; EUROPEAN
   ASSOCIATION; AMERICAN SOCIETY; SYNDROME IMPACT; HEART-FAILURE; KEY ROLE
AB ObjectiveThe interplay between metabolic syndrome (MS) and type 2 diabetes (T2D) on regional myocardial mechanics and the potential additional effects of their combination remain poorly understood. In this context, we evaluated left ventricular (LV) torsion and linear deformation at rest and under dobutamine (DB) stress in patients with T2D, MS or both. MethodsThirty-nine T2D patients without MS (T2D), 37 MS patients free from T2D (MS), 44 patients with both T2D and MS (T2D-MS group) and 38 healthy patients (control group) were prospectively recruited. Speckle-tracking echocardiography (STE) was conducted at rest and low dose DB to evaluate LV myocardial longitudinal (LS) as well as circumferential (CS) strain and early diastolic strain rate (LSrd, CSrd) and twist-untwist mechanics. ResultsAt rest, MS, T2D and controls presented with similar resting LS and LSrd while significant lower values were obtained in T2D-MS compared to controls. DB revealed reduced LS, LSrd, CS and CSrd in MS and T2D groups compared to controls. In T2-MS, the decline in LS and LSrd established at rest was exacerbated under DB. Stress echocardiography revealed also lower basal rotation and subsequently lower twist in MS and T2D patients compared to controls. T2D-MS showed major impairments of apical rotation and twist under DB stress, with values significantly lower compared to the 3 other groups. From stepwise multiple linear regression analysis, epicardial adipose tissue for Delta (rest to DB) LS, numbers of MS factors for Delta CS and Delta Twist emerged as major independent predictors. ConclusionThese results demonstrate synergic and additive effects of T2D and MS on LV torsion and linear deformation abnormalities in asymptomatic patients with metabolic diseases. They also highlight the usefulness of speckle tracking echocardiography under DB stress in detecting multidirectional myocardial mechanics impairments that can remain barely detectable at rest, such as in isolated T2D or MS patients.
C1 [Aboukhoudir, Falah; Philouze, Clothilde; Grandperrin, Antoine; Nottin, Stephane; Obert, Philippe] Avignon Univ, Lab Expt Cardiovasc Physiol, LaPEC, UPR4278, Avignon, France.
   [Aboukhoudir, Falah] Duffaut Hosp Ctr, Cardiol Dept, Avignon, France.
C3 Avignon Universite
RP Obert, P (corresponding author), Avignon Univ, Lab Expt Cardiovasc Physiol, LaPEC, UPR4278, Avignon, France.
EM philippe.obert@univ-avignon.fr
OI Grandperrin, Antoine/0009-0008-5372-0673; Philouze,
   Clothilde/0000-0002-0669-0263; Nottin, Stephane/0000-0001-7797-1137
FU French Society of Cardiology; Avignon hospital center; Platform 3A -
   European Regional Development Fund; French Ministry of Research, Higher
   Education and Innovation; Provence-Alpes-Cpte-d'Azur region;
   Departmental Council of Vaucluse; Urban Community of Avignon
FX This study was funded by a grant from the French Society of Cardiology.
   It was also supported by the Avignon hospital center and by the Platform
   3A, funded by the European Regional Development Fund, the French
   Ministry of Research, Higher Education and Innovation, the
   Provence-Alpes-Cpte-d'Azur region, the Departmental Council of Vaucluse,
   and the Urban Community of Avignon.
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NR 54
TC 1
Z9 1
U1 0
U2 1
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2297-055X
J9 FRONT CARDIOVASC MED
JI Front. Cardiovasc. Med.
PD SEP 8
PY 2022
VL 9
AR 991415
DI 10.3389/fcvm.2022.991415
PG 13
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 4W4LF
UT WOS:000860135600001
PM 36158831
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Eder, J
   Pfeiffer, L
   Wichert, SP
   Keeser, B
   Simon, MS
   Popovic, D
   Glocker, C
   Brunoni, AR
   Schneider, A
   Gensichen, J
   Schmitt, A
   Musil, R
   Falkai, P
AF Eder, Julia
   Pfeiffer, Lisa
   Wichert, Sven P.
   Keeser, Benjamin
   Simon, Maria S.
   Popovic, David
   Glocker, Catherine
   Brunoni, Andre R.
   Schneider, Antonius
   Gensichen, Jochen
   Schmitt, Andrea
   Musil, Richard
   Falkai, Peter
CA POKAL Grp
TI Deconstructing depression by machine learning: the POKAL-PSY study
SO EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
LA English
DT Article
DE MDD; Phenotyping; Machine learning; Biological psychiatry
ID HEART-RATE-VARIABILITY; METABOLIC SYNDROME; PRIMARY-CARE;
   ALPHA-1-ANTITRYPSIN DEFICIENCY; CARDIOVASCULAR RISK; MENTAL-DISORDERS;
   HEALTH; SCALE; VERSION; QUESTIONNAIRE
AB Unipolar depression is a prevalent and disabling condition, often left untreated. In the outpatient setting, general practitioners fail to recognize depression in about 50% of cases mainly due to somatic comorbidities. Given the significant economic, social, and interpersonal impact of depression and its increasing prevalence, there is a need to improve its diagnosis and treatment in outpatient care. Various efforts have been made to isolate individual biological markers for depression to streamline diagnostic and therapeutic approaches. However, the intricate and dynamic interplay between neuroinflammation, metabolic abnormalities, and relevant neurobiological correlates of depression is not yet fully understood. To address this issue, we propose a naturalistic prospective study involving outpatients with unipolar depression, individuals without depression or comorbidities, and healthy controls. In addition to clinical assessments, cardiovascular parameters, metabolic factors, and inflammatory parameters are collected. For analysis we will use conventional statistics as well as machine learning algorithms. We aim to detect relevant participant subgroups by data-driven cluster algorithms and their impact on the subjects' long-term prognosis. The POKAL-PSY study is a subproject of the research network POKAL (Predictors and Clinical Outcomes in Depressive Disorders; GRK 2621).
C1 [Eder, Julia; Wichert, Sven P.; Keeser, Benjamin; Simon, Maria S.; Glocker, Catherine; Schmitt, Andrea; Musil, Richard; Falkai, Peter] Ludwig Maximilians Univ Munchen, LMU Univ Hosp, Dept Psychiat & Psychotherapy, Nussbaumstr 7, D-80336 Munich, Germany.
   [Eder, Julia; Pfeiffer, Lisa; Schneider, Antonius; Gensichen, Jochen; Falkai, Peter] Grad Program POKAL Predictors & Outcomes Primary, Munich, Germany.
   [Popovic, David; Falkai, Peter] IMPRS TP, Munich, Germany.
   [Popovic, David; Falkai, Peter] Max Planck Inst Psychiat, Munich, Germany.
   [Brunoni, Andre R.] Univ Sao Paulo FMUSP, Fac Med, Dept Psychiat, Sao Paulo, SP, Brazil.
   [Schneider, Antonius] Tech Univ Munich, Inst Gen Practice & Hlth Serv Res, Sch Med, Munich, Germany.
   [Gensichen, Jochen] Ludwig Maximilians Univ Munchen, Inst Gen Practice & Family Med, Munich, Germany.
   [Schmitt, Andrea] Univ Sao Paulo, Inst Psychiat, Lab Neurosci LIM27, Sao Paulo, SP, Brazil.
   [Musil, Richard] Oberberg Specialist Clin Bad Tolz, Bad Tolz, Germany.
C3 University of Munich; Max Planck Society; Universidade de Sao Paulo;
   Technical University of Munich; University of Munich; Universidade de
   Sao Paulo
RP Eder, J (corresponding author), Ludwig Maximilians Univ Munchen, LMU Univ Hosp, Dept Psychiat & Psychotherapy, Nussbaumstr 7, D-80336 Munich, Germany.; Eder, J (corresponding author), Grad Program POKAL Predictors & Outcomes Primary, Munich, Germany.
EM j.eder@med.uni-muenchen.de
RI Popovic, David/AAV-8507-2020; Falkai, Peter/E-3273-2017; Brunoni,
   Andre/H-8394-2012; Musil, Richard/AAF-4331-2020
OI Popovic, David/0000-0002-2367-9437
FU Projekt DEAL; DFG (German Research Council) [GRK 2621]; Deutsche
   Forschungsgemeinschaft
FX Open Access funding enabled and organized by Projekt DEAL. The POKAL
   Group and the associated POKAL-PSY study are financially supported by
   the DFG (German Research Council) (POKAL grant no. GRK 2621). Deutsche
   Forschungsgemeinschaft, GRK 2621, Julia Eder, GRK 2621, Lisa
   Hattenkofer, GRK 2621, Peter Falkai.
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NR 129
TC 4
Z9 4
U1 1
U2 8
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0940-1334
EI 1433-8491
J9 EUR ARCH PSY CLIN N
JI Eur. Arch. Psych. Clin. Neurosci.
PD AUG
PY 2024
VL 274
IS 5
BP 1153
EP 1165
DI 10.1007/s00406-023-01720-9
EA DEC 2023
PG 13
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Psychiatry
GA XP9H5
UT WOS:001123061300001
PM 38091084
OA hybrid
DA 2025-06-11
ER

PT J
AU McElroy, SL
   Keck, PE
AF McElroy, Susan L.
   Keck, Paul E., Jr.
TI Obesity in Bipolar Disorder: An Overview
SO CURRENT PSYCHIATRY REPORTS
LA English
DT Article
DE Bipolar disorder; BD; Obesity; Co-occurrence; Comorbid eating disorders;
   Metabolic syndrome; Binge eating disorder; Weight management; Diet;
   Exercise; Pharmacotherapy; Bariatric surgery; Psychiatry
ID BODY-MASS INDEX; NATIONAL EPIDEMIOLOGIC SURVEY; PLACEBO-CONTROLLED
   EVALUATION; GENERAL MEDICAL CONDITIONS; WEIGHT-LOSS OUTCOMES;
   DOUBLE-BLIND; I-DISORDER; MENTAL-HEALTH; PHARMACOLOGICAL-TREATMENT;
   PSYCHIATRIC-DISORDERS
AB Bipolar disorder (BD) is associated with obesity, overweight, and abdominal obesity, and BD individuals with obesity have a greater illness burden. Factors related to BD, its treatment, and the individual may all contribute to BD's association with obesity. Management strategies for the obese BD patient include use of medications with better metabolic profiles, lifestyle interventions, and adjunctive pharmacotherapy for weight loss. Obesity-related psychiatric and medical comorbidities should also be assessed and managed. Bariatric surgery may be an option for carefully selected patients. Greater research into the theoretical underpinnings and clinical management of the BD-obesity connection is needed.
C1 [McElroy, Susan L.; Keck, Paul E., Jr.] Lindner Ctr HOPE, Mason, OH 45040 USA.
   [McElroy, Susan L.; Keck, Paul E., Jr.] Univ Cincinnati, Coll Med, Dept Psychiat & Behav Neurosci, Cincinnati, OH USA.
C3 University System of Ohio; University of Cincinnati
RP McElroy, SL (corresponding author), Lindner Ctr HOPE, 4075 Old Western Rd, Mason, OH 45040 USA.
EM susan.mcelroy@lindnercenter.org
FU Agency for Healthcare Research and Quality (AHRQ); Abbot; Alkermes;
   AstraZeneca; Bristol-Myers Squibb; Cephalon; Eli Lilly and Company;
   Forest; GlaxoSmithKline; Jazz Pharmaceuticals; Marriott Foundation;
   National Institute of Mental Health; Orexigen Therapeutics; Shire;
   Takeda Pharmaceuticals; Johnson Johnson
FX S. L. McElroy: board member of Alkermes and Shire; consultant for Eli
   Lilly and Company, Schering-Plough, and Shire; research funding from
   Agency for Healthcare Research and Quality (AHRQ), Abbot, Alkermes,
   AstraZeneca, Bristol-Myers Squibb, Cephalon, Eli Lilly and Company,
   Forest, GlaxoSmithKline, Jazz Pharmaceuticals, Marriott Foundation,
   National Institute of Mental Health, Orexigen Therapeutics, Shire, and
   Takeda Pharmaceuticals; and inventor on US Patent No. 6,323,236B2, Use
   of Sulfamate Derivatives for Treating Impulse Control Disorders, and
   along with the patent's assignee, University of Cincinnati, Cincinnati,
   OH, receives payments from Johnson & Johnson, which has exclusive rights
   under the patent; P. E. Keck: consultant for Bristol-Myers Squibb,
   Pamlab, and Forest Labs.
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NR 99
TC 95
Z9 100
U1 0
U2 31
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1523-3812
EI 1535-1645
J9 CURR PSYCHIAT REP
JI Curr. Psychiatry Rep.
PD DEC
PY 2012
VL 14
IS 6
BP 650
EP 658
DI 10.1007/s11920-012-0313-8
PG 9
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 033WB
UT WOS:000310831000008
PM 22903246
DA 2025-06-11
ER

PT J
AU Wheeler, AJ
   Harrison, J
   Mohini, P
   Nardan, J
   Tsai, A
   Tsai, E
AF Wheeler, Amanda J.
   Harrison, Jeff
   Mohini, Priya
   Nardan, Jeshika
   Tsai, Amy
   Tsai, Eve
TI Cardiovascular Risk Assessment and Management in Mental Health Clients:
   Whose Role is it Anyway?
SO COMMUNITY MENTAL HEALTH JOURNAL
LA English
DT Article
DE Mental illness; Cardiovascular risk; Risk reduction; Qualitative methods
ID MEDICAL-CARE; METABOLIC SYNDROME; EXCESS MORTALITY; PHYSICAL HEALTH;
   DISORDERS; BIPOLAR; ILLNESS; SCHIZOPHRENIA; ADULTS; INDIVIDUALS
AB People with serious mental illness have higher rates of morbidity and mortality from cardiovascular disease. This study describes health practitioners' views on their role and confidence assessing and managing cardiovascular risk. The key findings were of a widespread acknowledgement of the need to undertake systematic risk assessment and offer structured approaches to risk factor management. Barriers of client engagement, lack of good systems and poor information sharing between primary and secondary care providers were identified. Solutions discussed included a collaborative care model or the integration of physical health services, perhaps a general practitioner-led clinic, within the secondary care setting. Whilst there is a need to identify an optimal care model there is an even greater need to take some rather than no action.
C1 [Wheeler, Amanda J.] Univ Auckland, Clin Res & Resource Ctr, Fac Med & Hlth Sci, Waitemata Dist Hlth Board, Auckland 1, New Zealand.
   [Harrison, Jeff] Univ Auckland, Med Management Res Grp, Fac Med & Hlth Sci, Sch Pharm, Auckland 1, New Zealand.
C3 University of Auckland; University of Auckland
RP Wheeler, AJ (corresponding author), Univ Auckland, Clin Res & Resource Ctr, Fac Med & Hlth Sci, Waitemata Dist Hlth Board, Auckland 1, New Zealand.
EM amanda.wheeler@waitematadhb.govt.nz
RI Wheeler, Amanda/F-1854-2011; Harrison, Jeff/AAS-7001-2021
OI Wheeler, Amanda/0000-0001-9755-674X; Harrison, Jeff/0000-0001-8478-7469
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NR 42
TC 27
Z9 27
U1 0
U2 15
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0010-3853
EI 1573-2789
J9 COMMUNITY MENT HLT J
JI Community Ment. Health J.
PD DEC
PY 2010
VL 46
IS 6
BP 531
EP 539
DI 10.1007/s10597-009-9237-0
PG 9
WC Health Policy & Services; Public, Environmental & Occupational Health;
   Psychiatry
WE Social Science Citation Index (SSCI)
SC Health Care Sciences & Services; Public, Environmental & Occupational
   Health; Psychiatry
GA 672NH
UT WOS:000283591600002
PM 19688593
DA 2025-06-11
ER

PT J
AU Barbé-Tuana, FM
   Parisi, MM
   Panizzutti, BS
   Fries, GR
   Grun, LK
   Guma, FT
   Kapczinski, F
   Berk, M
   Gama, CS
   Rosa, AR
AF Barbe-Tuana, Florencia M.
   Parisi, Mariana M.
   Panizzutti, Bruna S.
   Fries, Gabriel R.
   Grun, Lucas K.
   Guma, Fatima T.
   Kapczinski, Flavio
   Berk, Michael
   Gama, Clarissa S.
   Rosa, Adriane R.
TI Shortened telomere length in bipolar disorder: a comparison of the early
   and late stages of disease
SO REVISTA BRASILEIRA DE PSIQUIATRIA
LA English
DT Article
DE Bipolar disorder; telomeres; telomere shortening; senescence; genetics;
   oxidative stress; inflammation; mania; depression; aging
ID PITUITARY-ADRENAL AXIS; OXIDATIVE STRESS; RATING-SCALE; DNA-DAMAGE;
   METAANALYSIS; BLOOD; ASSOCIATION; SENESCENCE; MORTALITY; ILLNESS
AB Objective: Bipolar disorder (BD) has been associated with increased rates of age-related diseases, such as type II diabetes, metabolic syndrome, osteoporosis, and cardiovascular disorders. Several biological findings have been associated with age-related disorders, including increased oxidative stress, inflammation, and telomere shortening. The objective of this study was to compare telomere length among participants with BD at early and late stages and age-and gender-matched healthy controls.
   Methods: Twenty-six euthymic subjects with BD and 34 healthy controls were recruited. Genomic DNA was extracted from peripheral blood and mean telomere length was measured using real-time quantitative polymerase chain reaction.
   Results: Telomere length was significantly shorter in both the early and late subgroups of BD subjects when compared to the respective controls (p = 0.002 and p = 0.005, respectively). The sample size prevented additional subgroup analyses, including potential effects of medication, smoking status, and lifestyle.
   Conclusion: This study is concordant with previous evidence of telomere shortening in BD, in both early and late stages of the disorder, and supports the notion of accelerated aging in BD.
C1 [Barbe-Tuana, Florencia M.; Parisi, Mariana M.; Grun, Lucas K.; Guma, Fatima T.] Univ Fed Rio Grande do Sul, Lab Biol Mol & Bioinformat, Programa Posgrad Bioquim, Porto Alegre, RS, Brazil.
   [Panizzutti, Bruna S.; Kapczinski, Flavio; Gama, Clarissa S.; Rosa, Adriane R.] Univ Fed Rio Grande do Sul, Hosp Clin Porto Alegre, Lab Psiquiatria Mol, Rua Ramiro Barcelos 2350, BR-90035903 Porto Alegre, RS, Brazil.
   [Panizzutti, Bruna S.; Kapczinski, Flavio; Gama, Clarissa S.] Univ Fed Rio Grande do Sul, Programa Posgrad Psiquiatria & Ciencias Comportam, Porto Alegre, RS, Brazil.
   [Fries, Gabriel R.] Univ Texas Hlth Sci Ctr Houston, Dept Psychiat & Behav Sci, Houston, TX 77030 USA.
   [Guma, Fatima T.] Univ Fed Rio Grande do Sul, Inst Ciencias Basicas Saude, Dept Bioquim, Lab Bioquim & Biol Celular Lipideos, Porto Alegre, RS, Brazil.
   [Berk, Michael] Deakin Univ, Sch Med, Strateg Res Ctr, Ctr Innovat Mental & Phys Hlth & Clin Treatment I, Geelong, Vic, Australia.
   [Berk, Michael] Univ Melbourne, Orygen Natl Ctr Excellence Youth Mental Hlth, Florey Inst Neurosci & Mental Hlth, Parkville, Vic, Australia.
   [Rosa, Adriane R.] Univ Fed Rio Grande do Sul, Dept Farmacol, Porto Alegre, RS, Brazil.
C3 Universidade Federal do Rio Grande do Sul; Hospital de Clinicas de Porto
   Alegre; Universidade Federal do Rio Grande do Sul; Universidade Federal
   do Rio Grande do Sul; Baylor College of Medicine; Baylor College Medical
   Hospital; University of Texas System; University of Texas Health Science
   Center Houston; Universidade Federal do Rio Grande do Sul; Deakin
   University; Orygen, The National Centre of Excellence in Youth Mental
   Health; University of Melbourne; Florey Institute of Neuroscience &
   Mental Health; Universidade Federal do Rio Grande do Sul
RP Rosa, AR (corresponding author), Univ Fed Rio Grande do Sul, Hosp Clin Porto Alegre, Lab Psiquiatria Mol, Rua Ramiro Barcelos 2350, BR-90035903 Porto Alegre, RS, Brazil.
EM adrianerrosa@gmail.com
RI Berk, Michael/AGH-9427-2022; Fries, Gabriel/C-1521-2009; Gama,
   Clarissa/Q-3697-2016; Panizzutti, Bruna/AAI-9726-2020; Guma,
   Fátima/G-1638-2013; Berk, Michael/M-7891-2013; Barbe-Tuana,
   Florencia/L-4881-2015; Rosa, Adriane/G-6923-2013; Fries, Gabriel
   R/P-8810-2014; Panizzutti, Bruna/L-5849-2015; Kapczinski,
   Flavio/D-3175-2013
OI Berk, Michael/0000-0002-5554-6946; Barbe-Tuana,
   Florencia/0000-0002-5358-3524; Rosa, Adriane/0000-0001-8629-4625; Fries,
   Gabriel R/0000-0002-5468-2612; Panizzutti, Bruna/0000-0002-8825-734X;
   Kapczinski, Flavio/0000-0001-8738-856X; Severino Gama,
   Clarissa/0000-0003-2235-9690
FU Ministerio da Ciencia, Tecnologia e Inovacao (MCT)/Conselho Nacional de
   Desenvolvimento Cientifico e Tecnologico (CNPq)-Universal
   [479305/2009-9, 473515/2013-0, 443526/2014-1]; CNPq Produtividade em
   Pesquisa [304443/2014-0]; Ciencias sem Fronteiras (CSF)
   [40.00032/2012-0]; Coordenacao de Aperfeicoamento de Pessoal de Nivel
   Superior (CAPES); CNPq; CAPES/CSF; CNPq/GD; National Health and Medical
   Research Council (NHMRC) [1059660]; L'Oreal Brasil; Academia Brasileira
   de Ciencias; UNESCO National Commission For Women in Science
FX This study received financial support from the Ministerio da Ciencia,
   Tecnologia e Inovacao (MCT)/Conselho Nacional de Desenvolvimento
   Cientifico e Tecnologico (CNPq)-Universal (grants 479305/2009-9,
   473515/2013-0, and 443526/2014-1), CNPq Produtividade em Pesquisa
   (304443/2014-0), and Ciencias sem Fronteiras (CSF) (40.00032/2012-0).
   FMB-T and BSP received fellowships from Coordenacao de Aperfeicoamento
   de Pessoal de Nivel Superior (CAPES). MMP and GRF received a fellowship
   from CNPq. BSP received a scholarship from CAPES/CSF and CNPq/GD. MB is
   supported by the National Health and Medical Research Council (NHMRC)
   Senior Principal Research Fellowship (1059660). ARR is grateful for the
   support provided by L'Oreal Brasil, Academia Brasileira de Ciencias, and
   the UNESCO National Commission For Women in Science.
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NR 49
TC 38
Z9 39
U1 0
U2 7
PU ASSOC BRASILEIRA PSIQUIATRIA
PI SAO PAULO
PA SUBSCRIPTION DEPARTMENT, RUA PEDRO DE TOLEDO, 967 - CASA 01, SAO PAULO,
   SP 04039-032  A, BRAZIL
SN 1516-4446
EI 1809-452X
J9 REV BRAS PSIQUIATR
JI Rev. Bras. Psiquiatr.
PD OCT-DEC
PY 2016
VL 38
IS 4
BP 281
EP 286
DI 10.1590/1516-4446-2016-1910
PG 6
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA EC9MR
UT WOS:000388469200004
PM 27798713
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Monda, V
   La Marra, M
   Perrella, R
   Caviglia, G
   Iavarone, A
   Chieffi, S
   Messina, G
   Carotenuto, M
   Monda, M
   Messina, A
AF Monda, Vincenzo
   La Marra, Marco
   Perrella, Raffaella
   Caviglia, Giorgio
   Iavarone, Alessandro
   Chieffi, Sergio
   Messina, Giovanni
   Carotenuto, Marco
   Monda, Marcellino
   Messina, Antonietta
TI Obesity and brain illness: from cognitive and psychological evidences to
   obesity paradox
SO DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
LA English
DT Review
DE obesity; cognitive decline; mood disorders; obesity paradox
ID BODY-MASS INDEX; C-REACTIVE PROTEIN; VASCULAR RISK-FACTORS; FOLLOW-UP;
   LATE-LIFE; METABOLIC SYNDROME; ALZHEIMER-TYPE; INSULIN-RESISTANCE;
   INCIDENT DEMENTIA; BARIATRIC SURGERY
AB Recent findings showed that obesity represents an additional risk factor to developing brain illness such as cognitive impairments and psychopathological disorders. However, some benefits of overweight in the elderly have been identified and an "obesity paradox" has been shown. Currently, it is still unknown how obesity and brain functioning could be linked, and the process by which body fat independently injures cognitive abilities and psychological wellbeing remains unclear. To establish the independent role of obesity on cognitive abilities and mental health, clarifying the role played by several factors and understanding their interaction is essential. In this review, we discuss the relationship between obesity and brain illness and underline the role played by confounders and other covariates to determine this link.
C1 [Monda, Vincenzo; La Marra, Marco; Chieffi, Sergio; Monda, Marcellino; Messina, Antonietta] Univ Campania Luigi Vanvitelli, Sect Human Physiol, Dept Expt Med, Naples, Italy.
   [Perrella, Raffaella; Caviglia, Giorgio] AORN Osped Colli, CTO Hosp, Neurol & Stroke Unit, Naples, Italy.
   [Iavarone, Alessandro] Univ Campania Luigi Vanvitelli, Dept Psychol, Naples, Italy.
   [Messina, Giovanni] Univ Foggia, Dept Clin & Expt Med, Via L Pinto, I-71122 Foggia, Italy.
   [Carotenuto, Marco] Univ Campania Luigi Vanvitelli, Clin Child & Adolescent Neuropsychiat, Dept Mental Hlth Phys & Prevent Med, Naples, Italy.
C3 Universita della Campania Vanvitelli; Universita della Campania
   Vanvitelli; University of Foggia; Universita della Campania Vanvitelli
RP Messina, G (corresponding author), Univ Foggia, Dept Clin & Expt Med, Via L Pinto, I-71122 Foggia, Italy.
EM giovanni.messina@unifg.it
RI Carotenuto, Marco/E-2575-2012; Messina, Antonietta/AHH-2383-2022;
   Messina, Giovanni/AAE-8668-2022; la marra, marco/HDL-8951-2022
OI Monda, Marcellino/0000-0002-7184-218X; Caviglia,
   Giorgio/0000-0003-2564-1966; CAROTENUTO, Marco/0000-0002-8136-7597;
   Perrella, Raffaella/0000-0003-2301-2066; Messina,
   Giovanni/0000-0002-1730-7063; Messina, Antonietta/0000-0001-8343-432X;
   Monda, Vincenzo/0000-0002-6083-5814; la marra, marco/0000-0001-7488-8493
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NR 118
TC 59
Z9 64
U1 1
U2 22
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-7007
J9 DIABETES METAB SYNDR
JI Diabetes Metab. Syndr. Obes.
PY 2017
VL 10
DI 10.2147/DMSO.S148392
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism
GA FO4YW
UT WOS:000416856400001
PM 29200883
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Ko, SH
   Baeg, MK
   Ko, SY
   Han, KD
AF Ko, Sun-Hye
   Baeg, Myong Ki
   Ko, Seung Yeon
   Han, Kyung-Do
TI Women Who Sleep More Have Reduced Risk of Peptic Ulcer Disease; Korean
   National Health and Nutrition Examination Survey (2008-2009)
SO SCIENTIFIC REPORTS
LA English
DT Article
ID HELICOBACTER-PYLORI; METABOLIC SYNDROME; GASTRIC-CANCER; DURATION;
   ASSOCIATION; POPULATION; MELATONIN; HYPERTENSION; MORTALITY; STRESS
AB Sleep is integral to life and sleep duration is important in sleep quality, physical, and psychological health. Disturbances in sleep duration have been associated with increased risk of metabolic disorders, hypertension, and overall mortality. Sleep disturbance has also been linked with various gastrointestinal disorders. However, the association between sleep and peptic ulcer disease (PUD) has not been evaluated. We investigated the association between sleep duration and PUD. Subjects were included from the fifth Korean National Health and Nutrition Examination Survey conducted from 2008-2009. Individuals with PUD were defined as those with a physician diagnosis of PUD. Daily sleep duration was established by asking participants the amount of time that they slept per day. Multiple logistic regression models were used to evaluate the association of PUD and sleep duration. This study included 14,290 participants (8,209 women). The prevalence of PUD was 5.7% and was higher in men (6.8%) than in women (4.9%). Women who slept >= 9 hours were significantly less likely to have PUD compared to women who slept 7 hours. In men, longer sleep duration (>= 9 hours) had a tendency toward PUD prevention. Our results suggest that longer sleep duration may play a protective role for PUD development.
C1 [Ko, Sun-Hye] Univ Ulsan, Coll Med, Asan Med Ctr, Dept Internal Med, Seoul, South Korea.
   [Baeg, Myong Ki] Catholic Kwandong Univ, Int St Marys Hosp, Coll Med, Dept Internal Med, Inchon, South Korea.
   [Baeg, Myong Ki] Catholic Kwandong Univ, Inst Translat & Clin Res, Inchon, South Korea.
   [Ko, Seung Yeon] Catholic Kwandong Univ, Incheon St Marys Hosp, Coll Med, Dept Surg, Inchon, South Korea.
   [Han, Kyung-Do] Catholic Univ Korea, Dept Prevent Med, Seoul, South Korea.
C3 University of Ulsan; Asan Medical Center; Catholic Kwandong University;
   Catholic Kwandong University; Catholic Kwandong University; Catholic
   University of Korea
RP Baeg, MK (corresponding author), Catholic Kwandong Univ, Int St Marys Hosp, Coll Med, Dept Internal Med, Inchon, South Korea.; Baeg, MK (corresponding author), Catholic Kwandong Univ, Inst Translat & Clin Res, Inchon, South Korea.
EM baegmk@gmail.com
RI Han, Kyungdo/JKH-7628-2023; Baeg, Myong Ki/O-1531-2017; Ko, Sun
   Hye/AGQ-5472-2022
OI Baeg, Myong Ki/0000-0002-4807-2447; Ko, Sun Hye/0000-0003-3387-3986
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NR 43
TC 15
Z9 15
U1 0
U2 17
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD NOV 10
PY 2016
VL 6
AR 36925
DI 10.1038/srep36925
PG 6
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA EC1OL
UT WOS:000387875300001
PM 27830741
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Liu, D
   Chen, WX
   Zhong, Q
AF Liu, Dong
   Chen, Wenxi
   Zhong, Qian
TI Multisystem Health Consequences of Prenatal Hyperandrogenism in
   Offspring
SO CLINICAL AND EXPERIMENTAL OBSTETRICS & GYNECOLOGY
LA English
DT Review
DE prenatal hyperandrogenism; offspring health; cardiovascular dysfunction;
   metabolic syndrome; reproductive disorders
ID POLYCYSTIC-OVARY-SYNDROME; ANDROGEN EXCESS; TESTOSTERONE; EXPOSURE;
   FETAL; DISORDERS; BEHAVIOR; GROWTH; RISK; METABOLISM
AB Objective: Prenatal hyperandrogenism, characterized by elevated androgen levels during pregnancy, has significant multisystem impacts on offspring health. This review systematically examines the effects of prenatal hyperandrogenism on the cardiovascular, metabolic, reproductive, and behavioral health of offspring. By analyzing existing research, this review aims to provide a comprehensive understanding of the long-term health impacts of prenatal hyperandrogenism, offering insights for clinical management and prevention of related diseases.Mechanism: A comprehensive search was performed in PubMed database with the key words: "hyperandrogenemia and child", "hyperandrogenemia and offspring", "androgen excess and child", "androgen excess and offspring", "prenatal hyperandrogenism", "prenatal androgen excess", and a combination of these terms to find quality articles published from 1995 to 2024.Findings in Brief: Elevated prenatal androgen levels disrupt normal fetal development, leading to long-term consequences such as cardiovascular dysfunction, including hypertension and cardiac hypertrophy, and metabolic abnormalities such as insulin resistance and metabolic syndrome. It has a significant impact on the long-term health of the offspring's reproductive system, with potential links to conditions such as polycystic ovary syndrome (PCOS). Furthermore, prenatal hyperandrogenism is associated with increased risks of neuropsychiatric disorders, including autism spectrum disorder (ASD) and anxiety.Conclusions: Elevated prenatal androgen levels disrupt normal fetal development, leading to long-term cardiovascular, metabolic, reproductive, and neuropsychiatric disorders. The underlying mechanisms involve hormonal regulation, placental function, oxidative stress, gene expression alterations, and metabolic programming. Further research is needed to develop effective interventions to mitigate these adverse effects.
C1 [Liu, Dong; Zhong, Qian] Sichuan Univ, West China Univ Hosp 2, Dept Gynecol & Obstet, Chengdu 610041, Sichuan, Peoples R China.
   [Liu, Dong; Zhong, Qian] Sichuan Univ, Key Lab Birth Defects & Related Dis Women & Childr, Minist Educ, Chengdu 610041, Sichuan, Peoples R China.
   [Chen, Wenxi] Nanchang Univ, Sch Queen Mary, Dept Clin Med, Nanchang 330006, Jiangxi, Peoples R China.
C3 Sichuan University; Ministry of Education - China; Sichuan University;
   Nanchang University
RP Zhong, Q (corresponding author), Sichuan Univ, West China Univ Hosp 2, Dept Gynecol & Obstet, Chengdu 610041, Sichuan, Peoples R China.; Zhong, Q (corresponding author), Sichuan Univ, Key Lab Birth Defects & Related Dis Women & Childr, Minist Educ, Chengdu 610041, Sichuan, Peoples R China.
EM cdcd91761@163.com
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NR 73
TC 0
Z9 0
U1 2
U2 3
PU IMR PRESS
PI ROBINSON
PA 112 ROBINSON RD, ROBINSON, SINGAPORE
SN 0390-6663
EI 2709-0094
J9 CLIN EXP OBSTET GYN
JI Clin. Exp. Obstet. Gynecol.
PD OCT
PY 2024
VL 51
IS 10
AR 223
DI 10.31083/j.ceog5110223
PG 9
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA L9C8J
UT WOS:001353635900013
OA gold
DA 2025-06-11
ER

PT J
AU Dikeç, G
   Arabaci, LB
   Uzunoglu, GB
   Mizrak, SD
AF Dikec, Gul
   Arabaci, Leyla Baysan
   Uzunoglu, Gulcin Boluk
   Mizrak, Selin Demet
TI An Investigation of Cardiovascular Risks in a Group of Children and
   Adolescents Who Use Atypical Antipsychotics
SO ISSUES IN MENTAL HEALTH NURSING
LA English
DT Article
ID METABOLIC SYNDROME; ADVERSE EVENTS; SCHIZOPHRENIA; MEDICATIONS;
   RISPERIDONE; OLANZAPINE; BIPOLAR; HEALTH; CARE
AB This study was conducted to identify the metabolic parameters and body measurements associated with cardiovascular risks in a group of children and adolescents who as part of inpatient treatment received atypical antipsychotics at a psychiatric hospital in Turkey. Body mass indexes (BMIs), waist circumferences (WCs), diastolic blood pressures (DBPs), systolic blood pressures (SBPs) and heart rates (HRs) of the patients were evaluated during hospitalization and at discharge. A statistically significant difference was found among the mean BMIs, WCs, DBPs and HRs of the patients at the stages of their hospitalization and discharge (p < 0.05). On the basis of the study findings, it is recommended that mental health nurses evaluate these risk factors in children and adolescents and provide education on this subject to the patients and their families.
C1 [Dikec, Gul] Istinye Univ, Dept Nursing, Fac Heath Sci, Rd Edirne Cirpici, TR-34010 Istanbul, Turkey.
   [Arabaci, Leyla Baysan] Izmir Katip Celebi Univ, Dept Psychiat Nursing, Fac Hlth Sci, Izmir, Turkey.
   [Uzunoglu, Gulcin Boluk] Manisa Psychiat & Neurol Hosp, Child & Adolescent Psychiat Clin, Manisa, Turkey.
   [Mizrak, Selin Demet] Manisa Psychiat & Neurol Hosp, Manisa, Turkey.
C3 Istinye University; Izmir Katip Celebi University; Manisa Mental Health
   Diseases Hospital; Manisa Mental Health Diseases Hospital
RP Dikeç, G (corresponding author), Istinye Univ, Dept Nursing, Fac Heath Sci, Rd Edirne Cirpici, TR-34010 Istanbul, Turkey.
EM guloban@hotmail.com
RI BAYSAN ARABACI, Leyla/AGS-7115-2022; Dikec, Gul/L-1623-2018
OI Dikec, Gul/0000-0002-7593-4014; BAYSAN ARABACI,
   Leyla/0000-0002-0314-6350
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NR 42
TC 3
Z9 3
U1 0
U2 2
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 0161-2840
EI 1096-4673
J9 ISSUES MENT HEALTH N
JI Issues Ment. Health Nurs.
PY 2017
VL 38
IS 10
BP 872
EP 880
DI 10.1080/01612840.2017.1355946
PG 9
WC Nursing; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Psychiatry
GA FM4BD
UT WOS:000414954900015
PM 28872927
DA 2025-06-11
ER

PT J
AU Jahangard, L
   Solgy, R
   Salehi, I
   Taheri, SK
   Holsboer-Trachsler, E
   Haghighi, M
   Brand, S
AF Jahangard, Leila
   Solgy, Rahmat
   Salehi, Iraj
   Taheri, Seyed Kazem
   Holsboer-Trachsler, Edith
   Haghighi, Mohammad
   Brand, Serge
TI Cholecystokinin (CCK) level is higher among first time suicide
   attempters than healthy controls, but is not associated with higher
   depression scores
SO PSYCHIATRY RESEARCH
LA English
DT Article
DE Cholecystokinin; Suicide attempts; Depression; Biological marker
ID ECONOMIC-CRISIS; METABOLIC SYNDROME; MENTAL-DISORDERS; SOUTH-KOREA;
   RISK; RATES; IDEATION; INSOMNIA; IMPACT; SAMPLE
AB Suicide and suicide attempts are dramatic events for both the individuals concerned and for their social environments. Efforts have been made to identify reliable biological predictors of suicide and suicide attempts. In the present study, we focused on one potential marker, cholecystokinin (CCK), among first time suicide at tempters. A total of 25 suicide attempters (mean age: 30 years; 80% females) and 23 healthy controls were enrolled in the present cross-sectional study. Experts rated participants' symptoms of depression (Hamilton Depression Rating Scale; HDRS). Blood levels of CCK levels were assessed. Suicide attempters had CCK levels 22.67 times higher and HDRS scores 14.33 higher than healthy controls. CCK levels were only weakly associated with HDRS scores. CCK appears to be a fairly reliable biomarker for suicide attempts. However, CCK levels were not associated with depression scores, making it difficult to match biological markers to depressive behaviour.
C1 [Jahangard, Leila; Solgy, Rahmat; Salehi, Iraj; Taheri, Seyed Kazem; Haghighi, Mohammad] Hamadan Univ Med Sci, Res Ctr Behav Disorders & Subst Abuse, Hamadan, Iran.
   [Holsboer-Trachsler, Edith; Brand, Serge] Univ Basel, Psychiat Clin UPK, Ctr Affect Stress & Sleep Disorders ZASS, Basel, Switzerland.
   [Brand, Serge] Univ Basel, Dept Sport Exercise & Hlth, Div Sport & Psychosocial Hlth, Basel, Switzerland.
   [Brand, Serge] Kermanshah Univ Med Sci, Psychiat Dept, Subst Abuse Prevent Res Ctr, Kermanshah, Iran.
   [Brand, Serge] Kermanshah Univ Med Sci, Sleep Disorders Res Ctr, Kermanshah, Iran.
C3 Hamadan University of Medical Sciences; University of Basel; University
   of Basel; Swiss School of Public Health (SSPH+); Kermanshah University
   of Medical Sciences; Kermanshah University of Medical Sciences
RP Haghighi, M (corresponding author), Hamadan Univ Med Sci, Res Ctr Behav Disorders & Subst Abuse, Hamadan, Iran.
EM haghighi@umsha.ac.ir; serge.brand@upkbs.ch
RI Brand, Serge/H-7159-2019; Jahangard, Leila/R-4159-2017; Salehi,
   Iraj/M-5556-2017; Haghighi, Mohammad/GNH-4892-2022; taheri, seyed
   kazem/A-1301-2018
OI taheri, seyed kazem/0000-0001-6327-8454; Brand,
   Serge/0000-0003-2175-2765
CR Ahmadpanah M, 2017, COMPR PSYCHIAT, V77, P71, DOI 10.1016/j.comppsych.2017.05.008
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NR 55
TC 12
Z9 14
U1 0
U2 8
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0165-1781
EI 1872-7123
J9 PSYCHIAT RES
JI Psychiatry Res.
PD AUG
PY 2018
VL 266
BP 40
EP 46
DI 10.1016/j.psychres.2018.05.031
PG 7
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA GM1IP
UT WOS:000437819700008
PM 29803785
DA 2025-06-11
ER

PT J
AU Markova, I
   Hüttl, M
   Oliyarnyk, O
   Kacerova, T
   Haluzik, M
   Kacer, P
   Seda, O
   Malinska, H
AF Markova, Irena
   Huttl, Martina
   Oliyarnyk, Olena
   Kacerova, Tereza
   Haluzik, Martin
   Kacer, Petr
   Seda, Ondrej
   Malinska, Hana
TI The effect of dicarbonyl stress on the development of kidney dysfunction
   in metabolic syndrome - a transcriptomic and proteomic approach
SO NUTRITION & METABOLISM
LA English
DT Article
DE Metabolic syndrome; Methylglyoxal; Kidney dysfunction; Transcriptomics;
   Proteomics; Metabolomics; Microvascular complications
ID INFLAMMATORY CYTOKINES; DIABETIC-NEPHROPATHY; GENE-EXPRESSION;
   RENAL-FUNCTION; GLYOXALASE 1; TGF-BETA; METHYLGLYOXAL; GLYCATION;
   DISEASE; PATHWAY
AB Background and aimsDicarbonyl stress plays an important role in the pathogenesis of microvascular complications that precede the formation of advanced glycation end products, and contributes to the development of renal dysfunction. In renal cells, toxic metabolites like methylglyoxal lead to mitochondrial dysfunction and protein structure modifications.In our study, we investigated the effect of methylglyoxal on metabolic, transcriptomic, metabolomic and proteomic profiles in the context of the development of kidney impairment in the model of metabolic syndrome.Materials and methodsDicarbonyl stress was induced by intragastric administration of methylglyoxal (0.5mg/kg bw for 4weeks) in a strain of hereditary hypertriglyceridaemic rats with insulin resistance and fatty liver.ResultsMethylglyoxal administration aggravated glucose intolerance (AUC(0-120)p<0.05), and increased plasma glucose (p<0.01) and insulin (p<0.05). Compared to controls, methylglyoxal-treated rats exhibited microalbuminuria (p<0.01). Targeted proteomic analysis revealed increases in urinary secretion of pro-inflammatory parameters (MCP-1, IL-6, IL-8), specific collagen IV fragments and extracellular matrix proteins. Urine metabolomic biomarkers in methylglyoxal-treated rats were mainly associated with impairment of membrane phospholipids (8-isoprostane, 4-hydroxynonenal).Decreased levels of glutathione (p<0.01) together with diminished activity of glutathione-dependent antioxidant enzymes contributed to oxidative and dicarbonyl stress. Methylglyoxal administration elevated glyoxalase 1 expression (p<0.05), involved in methylglyoxal degradation. Based on comparative transcriptomic analysis of the kidney cortex, 96 genes were identified as differentially expressed (FDR<0.05). Network analysis revealed an over-representation of genes related to oxidative stress and pro-inflammatory signalling pathways as well as an inhibition of angiogenesis suggesting its contribution to renal fibrosis.ConclusionOur results support the hypothesis that dicarbonyl stress plays a key role in renal microvascular complications. At the transcriptome level, methylglyoxal activated oxidative and pro-inflammatory pathways and inhibited angiogenesis. These effects were further supported by the results of urinary proteomic and metabolomic analyses.
C1 [Markova, Irena; Huttl, Martina; Oliyarnyk, Olena; Haluzik, Martin; Malinska, Hana] Inst Clin & Expt Med, Ctr Expt Med, Prague, Czech Republic.
   [Kacerova, Tereza] UCL, Dept Chem, London, England.
   [Kacer, Petr] Czech Univ Life Sci, Prague, Czech Republic.
   [Seda, Ondrej] Charles Univ Prague, Fac Med 1, Inst Biol & Med Genet, Prague, Czech Republic.
   [Seda, Ondrej] Gen Univ Hosp Prague, Prague, Czech Republic.
C3 Institute for Clinical & Experimental Medicine (IKEM); University of
   London; University College London; Czech University of Life Sciences
   Prague; Charles University Prague; General University Hospital Prague
RP Malinska, H (corresponding author), Inst Clin & Expt Med, Ctr Expt Med, Prague, Czech Republic.
EM haml@ikem.cz
RI Oliyarnyk, Olena/Q-6380-2019; Kacerova, Tereza/AAV-7242-2021; Haluzik,
   Martin/I-8190-2017; Kacer, Petr/AAW-2355-2021; Seda, Ondrej/A-2058-2008
OI Markova, Irena/0000-0002-4331-7636; Kacer, Petr/0000-0002-5905-3516;
   Seda, Ondrej/0000-0001-8498-5895; Kacerova, Tereza/0000-0002-9477-0182;
   Oliyarnyk, Olena/0000-0002-4912-6187
FU Ministry of Health of the Czech Republic under the conceptual
   development of research organisations programme (Institute for Clinical
   and Experimental Medicine - IKEM) [IN 00023001, RVO VFN64165]; Ministry
   of Education, Youth and Sports of the CR as part of National
   Sustainability Programme II (BIOCEV-FAR project) [LQ1604]; BIOCEV
   project [CZ.1.05/1.1.00/02.0109]
FX This work was supported by the Ministry of Health of the Czech Republic
   under the conceptual development of research organisations programme
   (Institute for Clinical and Experimental Medicine - IKEM, IN 00023001
   and RVO VFN64165, General University Hospital in Prague, Czech Republic)
   and by the Ministry of Education, Youth and Sports of the CR as part of
   LQ1604 National Sustainability Programme II (BIOCEV-FAR project) and the
   BIOCEV project (CZ.1.05/1.1.00/02.0109).
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NR 35
TC 13
Z9 14
U1 2
U2 27
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1743-7075
J9 NUTR METAB
JI Nutr. Metab.
PD AUG 1
PY 2019
VL 16
AR 51
DI 10.1186/s12986-019-0376-1
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA IN4UI
UT WOS:000478671600001
PM 31388341
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Paz, G
   Licinio, J
   Wong, ML
AF Paz-Filho, Gilberto
   Licinio, Julio
   Wong, Ma-Li
TI Pathophysiological basis of cardiovascular disease and depression: a
   chicken-and-egg dilemma
SO REVISTA BRASILEIRA DE PSIQUIATRIA
LA English
DT Article
DE Heart; Depression; Cardiovascular disease; Coronary artery disease;
   Antidepressive agents/adverse effects
ID CORONARY-HEART-DISEASE; TISSUE-PLASMINOGEN ACTIVATOR; ACUTE
   MYOCARDIAL-INFARCTION; PSYCHOSOCIAL RISK-FACTORS; C-REACTIVE PROTEIN;
   MAJOR DEPRESSION; ARTERY-DISEASE; PLATELET REACTIVITY; METABOLIC
   SYNDROME; RATE-VARIABILITY
AB Objective: To describe the pathophysiological basis linking cardiovascular disease (CVD) and depression; to discuss the causal relationship between them, and to review the effects of antidepressant treatment on cardiovascular disease. Method: A review of the literature based on the PubMed database. Discussion: Depression and cardiovascular disease are both highly prevalent. Several studies have shown that the two are closely related. They share common pathophysiological etiologies or co-morbidities, such as alterations in the hypothalamic-pituitary axis, cardiac rhythm disturbances, and hemorheologic, inflammatory and serotoninergic changes. Furthermore, antidepressant treatment is associated with worse cardiac outcomes (in case of tricyclics), which are not observed with selective serotonin reuptake inhibitors. Conclusion: Although there is a strong association between depression and cardiovascular disease, it is still unclear whether depression is actually a causal factor for CVD, or is a mere consequence, or whether both conditions share a common pathophysiological etiology. Nevertheless, both conditions must be treated concomitantly. Drugs other than tricyclics must be used, when needed, to treat the underlying depression and not as mere prophylactic of cardiac outcomes.
C1 [Paz-Filho, Gilberto; Licinio, Julio; Wong, Ma-Li] Australian Natl Univ, John Curtin Sch Med Res, Canberra, ACT 2601, Australia.
C3 Australian National University; John Curtin School of Medical Research
RP Wong, ML (corresponding author), Bldg 131,Garran Rd, Acton, ACT 0200, Australia.
EM mali.wong@anu.edu.au
RI Wong, Ma-Li/ABD-5525-2020; Paz-Filho, Gilberto/C-6499-2008; Licinio,
   Julio/L-4244-2013; Wong, Ma-Li/D-7903-2011
OI Licinio, Julio/0000-0001-6905-5884; Wong, Ma-Li/0000-0003-1512-3073;
   Paz-Filho, Gilberto/0000-0002-5940-4996
FU NIH [GM61394, RR017365, MH062777, RR000865, RR16996, HG002500,
   DK063240]; Australian National University
FX Our work has been supported by NIH grants GM61394, RR017365, MH062777,
   RR000865, RR16996, HG002500, and DK063240, and by the Australian
   National University.
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NR 165
TC 26
Z9 32
U1 0
U2 8
PU ASSOC BRASILEIRA PSIQUIATRIA
PI SAO PAULO
PA SUBSCRIPTION DEPARTMENT, RUA PEDRO DE TOLEDO, 967 - CASA 01, SAO PAULO,
   SP 04039-032  A, BRAZIL
SN 1516-4446
EI 1809-452X
J9 REV BRAS PSIQUIATR
JI Rev. Bras. Psiquiatr.
PD JUN
PY 2010
VL 32
IS 2
BP 181
EP 191
DI 10.1590/S1516-44462010000200015
PG 11
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 619AU
UT WOS:000279399900015
PM 20658057
OA Green Accepted, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Morimoto, HK
   Simao, ANC
   de Almeida, ERD
   Ueda, LT
   Oliveira, SR
   de Oliveira, NB
   Petenucci, DL
   Panis, C
   Cecchini, R
   Dichi, I
   Reiche, EMV
AF Morimoto, Helena K.
   Simao, Andrea N. C.
   de Almeida, Elaine R. D.
   Ueda, Luiz T.
   Oliveira, Sayonara R.
   de Oliveira, Natalia B.
   Petenucci, Diego L.
   Panis, Carolina
   Cecchini, Rubens
   Dichi, Isaias
   Reiche, Edna M. V.
TI Role of metabolic syndrome and antiretroviral therapy in adiponectin
   levels, and oxidative stress in HIV-1 infected patients
SO NUTRITION
LA English
DT Article
DE Adiponectin; HIV-1; Oxidative stress; ART; Metabolic syndrome
ID HIV-INFECTED PATIENTS; INSULIN-RESISTANCE; URIC-ACID; PREVALENCE;
   LIPODYSTROPHY; HEART; INFLAMMATION; ACTIVATION; PROTEINS
AB Objective: HIV-1 infection is accompanied by severe metabolic and immune dysfunction. The aim of this study was to evaluate the role of metabolic syndrome (MetS) and antiretroviral therapy (ART) utilization on the adiponectin levels and oxidative stress in patients infected with HIV-1.
   Methods: We allocated 285 patients into four groups: group 1: patients without MetS who were not using ART; group 2: patients without MetS using ART; group 3: patients with MetS who were not using ART; and group 4: patients with MetS using ART. Biochemical, immunologic, and oxidative stress parameters were measured.
   Results: Group 4 exhibited higher lipoperoxides when compared with group 1 (P < 0.0001) and higher advanced oxidation protein products (AOPP) compared with group 2 or group 1 (P < 0.0001). Group 3 also presented higher AOPP than group 2 (P < 0.05). Group 4 showed lower adiponectin levels compared with groups 1 or 2 (P < 0.0001). Similarly, group 3 presented lower adiponectin levels compared with group 2 (P < 0.05) or group 1 (P < 0.0001). Multivariate analysis showed that both an increase in AOPP and a decrease in total radical-trapping antioxidant parameter/uric acid were independently associated with MetS in HIV-1 patients. Regarding immunologic markers of HIV-1 disease progression and viral replication, group 4 exhibited significantly higher CD45+, CD3+, and CD4+ T cells count compared with group 2 (P < 0.01).
   Conclusion: HIV-1infected patients with MetS exhibited hypoadiponectinemia and increased oxidative stress, and these findings were not influenced by ART use. The findings of the present study allow the suggestion that MetS and inflammation might be mainly responsible for the aforementioned features. More studies are needed to verify whether drugs or food, which yield increased adiponectinemia and decreased oxidative stress, could reduce cardiovascular risk in HIV-infected patients. (C) 2014 Elsevier Inc. All rights reserved.
C1 [Morimoto, Helena K.; Simao, Andrea N. C.; de Almeida, Elaine R. D.; Oliveira, Sayonara R.; de Oliveira, Natalia B.; Petenucci, Diego L.; Reiche, Edna M. V.] Univ Londrina, Dept Pathol Clin Anal & Toxicol, Londrina, Parana, Brazil.
   [Ueda, Luiz T.] Secretariat Hlth Parana State, Integrated Ctr Infect Dis, Londrina, Parana, Brazil.
   [Panis, Carolina; Cecchini, Rubens] Univ Londrina, Lab Pathophysiol Free Rad, Londrina, Parana, Brazil.
   [Dichi, Isaias] Univ Londrina, Dept Internal Med, Londrina, Parana, Brazil.
RP Simao, ANC (corresponding author), Univ Londrina, Dept Pathol Clin Anal & Toxicol, Londrina, Parana, Brazil.
EM Deianame@yahoo.com.br
RI Simão, Andrea/AAM-4892-2021; Reiche, EDNa/AAD-4186-2020; Reiche, Edna
   Maria Vissoci/C-4102-2013; Cecchini, Rubens/D-9811-2013; PANIS,
   CAROLINA/O-1490-2015
OI Reiche, Edna Maria Vissoci/0000-0001-6507-2839; Cecchini,
   Rubens/0000-0001-9941-2344; PANIS, CAROLINA/0000-0002-0104-4369
FU Institutional Program for Scientific Initiation Scholarship (PIBIC) of
   the National Council for Scientific and Technological Development (CNPq)
FX This study was supported by grants obtained from the Institutional
   Program for Scientific Initiation Scholarship (PIBIC) of the National
   Council for Scientific and Technological Development (CNPq). ANC Simao
   and EMV Reiche were responsible for the conception and design of the
   study. HK Morimoto, ERD de Almeida, LT Ueda, JA de Oliveira, SR
   Oliveira, NB Oliveira, DL Petenucci, C Panis, and R Cecchini were
   responsible for the acquisition of data. HK Morimoto, ANC Simao, I
   Dichi, and EMV Reiche analyzed and interpreted the data. ANC Simao and I
   Dichi drafted the article and revised it critically for important
   intellectual content. EMV Reiche gave final approval of the article to
   be submitted. The authors declare there is no conflict of interest
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NR 40
TC 18
Z9 18
U1 0
U2 3
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0899-9007
EI 1873-1244
J9 NUTRITION
JI Nutrition
PD NOV-DEC
PY 2014
VL 30
IS 11-12
BP 1324
EP 1330
DI 10.1016/j.nut.2014.03.017
PG 7
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA AQ7AE
UT WOS:000342964200013
PM 25280407
DA 2025-06-11
ER

PT J
AU Boden, G
   Homko, C
   Barrero, CA
   Stein, TP
   Chen, XH
   Cheung, P
   Fecchio, C
   Koller, S
   Merali, S
AF Boden, Guenther
   Homko, Carol
   Barrero, Carlos A.
   Stein, T. Peter
   Chen, Xinhua
   Cheung, Peter
   Fecchio, Chiara
   Koller, Sarah
   Merali, Salim
TI Excessive caloric intake acutely causes oxidative stress, GLUT4
   carbonylation, and insulin resistance in healthy men
SO SCIENCE TRANSLATIONAL MEDICINE
LA English
DT Article
ID ENDOPLASMIC-RETICULUM STRESS; 3T3-L1 ADIPOCYTES; ADIPOSE-TISSUE;
   BODY-COMPOSITION; OBESITY; SENSITIVITY; INFLAMMATION; PROTEIN;
   SUPPLEMENTATION; DISEASE
AB Obesity-linked insulin resistance greatly increases the risk for type 2 diabetes, hypertension, dyslipidemia, and nonalcoholic fatty liver disease, together known as the metabolic or insulin resistance syndrome. How obesity promotes insulin resistance remains incompletely understood. Plasma concentrations of free fatty acids and proinflammatory cytokines, endoplasmic reticulum (ER) stress, and oxidative stress are all elevated in obesity and have been shown to induce insulin resistance. However, they may be late events that only develop after chronic excessive nutrient intake. The nature of the initial event that produces insulin resistance at the beginning of excess caloric intake and weight gain remains unknown. We show that feeding healthy men with similar to 6000 kcal/day of the common U.S. diet [similar to 50% carbohydrate (CHO), similar to 35% fat, and similar to 15% protein] for 1 week produced a rapid weight gain of 3.5 kg and the rapid onset (after 2 to 3 days) of systemic and adipose tissue insulin resistance and oxidative stress but no inflammatory or ER stress. In adipose tissue, the oxidative stress resulted in extensive oxidation and carbonylation of numerous proteins, including carbonylation of GLUT4 near the glucose transport channel, which likely resulted in loss of GLUT4 activity. These results suggest that the initial event caused by overnutrition may be oxidative stress, which produces insulin resistance, at least in part, via carbonylation and oxidation-induced inactivation of GLUT4.
C1 [Boden, Guenther; Homko, Carol; Cheung, Peter] Temple Univ, Sch Med, Div Endocrinol Diabet Metab, Philadelphia, PA 19140 USA.
   [Boden, Guenther; Homko, Carol; Cheung, Peter] Temple Univ, Sch Med, Clin Res Unit, Philadelphia, PA 19140 USA.
   [Barrero, Carlos A.; Fecchio, Chiara; Merali, Salim] Temple Univ, Sch Pharm, Dept Pharmaceut Sci, Philadelphia, PA 19140 USA.
   [Barrero, Carlos A.; Fecchio, Chiara; Merali, Salim] Temple Univ, Sch Pharm, Moulder Ctr Drug Discovery, Proteom Metabol Facil, Philadelphia, PA 19140 USA.
   [Stein, T. Peter] Rowan Univ, Sch Osteopath Med, Dept Surg, Stratford, NJ 08084 USA.
   [Chen, Xinhua] Rowan Univ, Sch Osteopath Med, Dept Obstet & Gynecol, Stratford, NJ 08084 USA.
   [Koller, Sarah] Temple Univ, Dept Surg, Sch Med, Philadelphia, PA 19140 USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE); Temple
   University; Pennsylvania Commonwealth System of Higher Education
   (PCSHE); Temple University; Pennsylvania Commonwealth System of Higher
   Education (PCSHE); Temple University; Pennsylvania Commonwealth System
   of Higher Education (PCSHE); Temple University; Rowan University; Rowan
   University School of Osteopathic Medicine; Rowan University; Rowan
   University School of Osteopathic Medicine; Pennsylvania Commonwealth
   System of Higher Education (PCSHE); Temple University
RP Boden, G (corresponding author), Temple Univ, Sch Med, Div Endocrinol Diabet Metab, Philadelphia, PA 19140 USA.
EM bodengh@tuhs.temple.edu; smerali@temple.edu
RI Barrero, Carlos/AGJ-1273-2022; Stein, T./R-4244-2019
OI Barrero, Carlos/0000-0001-5779-6642
FU NIH [R01-DK090588]; American Diabetes Association [1-10-CT-06]
FX Funding: This work was supported by grants from the NIH (R01-DK090588 to
   G.B. and S.M.) and the American Diabetes Association (1-10-CT-06 to
   G.B.).
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NR 44
TC 160
Z9 178
U1 2
U2 28
PU AMER ASSOC ADVANCEMENT SCIENCE
PI WASHINGTON
PA 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA
SN 1946-6234
EI 1946-6242
J9 SCI TRANSL MED
JI Sci. Transl. Med.
PD SEP 9
PY 2015
VL 7
IS 304
AR 304re7
DI 10.1126/scitranslmed.aac4765
PG 9
WC Cell Biology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Research & Experimental Medicine
GA CQ9OG
UT WOS:000360943900006
PM 26355033
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Lim, YH
   kIm, WJ
   Shin, CH
   Park, HY
AF Lim, Yong-Ho
   kIm, Won-Je
   Shin, Chul-Ho
   Park, Hun -Young
TI Relationship between prevalence of cardiometabolic diseases,
   self-reported memory loss, and self-reported depressed mood of older
   adults in Korea according to frailty and physical activity status
SO JOURNAL OF MENS HEALTH
LA English
DT Article
DE Older adults; Frailty; Physical activity; Self-reported memory loss;
   Self-reported depressed mood
ID MILD COGNITIVE IMPAIRMENT; METABOLIC SYNDROME; STROKE; RISK
AB As the older population increases worldwide, frailty is the area of research that deserve further investigation and is considered a major social and public health concern. Frailty appears physically and mentally, and recently, the term cognitive frailty has been used to combine physical frailty and mild cognitive impairment syndrome. Frailty in older adults is characterized by low physical activity levels and a sedentary lifestyle. Physical activity is essential in managing mental health issues such as depression and can improve the executive function and memory of older adults with mild cognitive impairment. Therefore, this study aimed to examine the prevalence of cardiometabolic diseases, self-reported memory loss, and depression among older adults in Korea according to frailty and physical activity status. Using data from the 2019 Korea National Health and Nutrition Survey, this study analyzed 613 community-dwelling older males aged >= 65 years. Physical activity was measured using a Global Physical Activity Questionnaire. A health-related quality of life instrument with eight items (HINT-8) was used to assess self-reported memory loss and depressed mood. Relationships between physical activity levels, self-reported memory loss and depressed mood were analyzed using logistic regression. The incidence of HINT-8 memory (0.52 (95% confidence interval (CI): 0.32-0.85)) was significantly lower in the Physical Activity Level (PAL)-high/prefrail; the incidence of HINT-8 depression (0.35 (95% CI: 0.21-0.59); 0.29 (95% CI: 0.17-0.52)) was significantly lower in the and PAL-high/pre-frail. We verified that the group with PAL-low/frail had the highest self-reported memory loss and depressed mood, suggesting that more physical activity may reduce self-reported memory loss and depressed mood among frail older males in Korea. However further research is needed to analyze the level of physical activity separately between work and leisure.
C1 [Lim, Yong-Ho; kIm, Won-Je; Park, Hun -Young] Konkuk Univ, Grad Sch, Dept Sports Med & Sci, Seoul 05029, South Korea.
   [Shin, Chul-Ho] Namseoul Univ, Dept Sports & Hlth Care, Cheonan 31020, South Korea.
   [Park, Hun -Young] Konkuk Univ, Phys Act & Performance Inst, Seoul 05029, South Korea.
C3 Konkuk University; Namseoul University; Konkuk University
RP Park, HY (corresponding author), Konkuk Univ, Grad Sch, Dept Sports Med & Sci, Seoul 05029, South Korea.; Park, HY (corresponding author), Konkuk Univ, Phys Act & Performance Inst, Seoul 05029, South Korea.
EM parkhy1980@konkuk.ac.kr
RI Park, Hun-Young/J-2934-2019
FU FUNDING
FX <B>FUNDING</B> This research received no external funding.
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NR 57
TC 0
Z9 0
U1 0
U2 6
PU MRE PRESS
PI SINGAPORE
PA 14 ROBINSON RD #08-01A FAR EAST FINANCE, SINGAPORE, SINGAPORE
SN 1875-6867
EI 1875-6859
J9 J MENS HEALTH
JI J. Mens Health
PD FEB
PY 2024
VL 20
IS 2
BP 11
EP 20
DI 10.22514/jomh.2024.019
PG 10
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA KJ3E5
UT WOS:001179544800003
OA gold
DA 2025-06-11
ER

PT J
AU Sikorska, K
   Stalke, P
   Romanowski, T
   Rzepko, R
   Bielawski, KP
AF Sikorska, Katarzyna
   Stalke, Piotr
   Romanowski, Tomasz
   Rzepko, Robert
   Bielawski, Krzysztof Piotr
TI Liver steatosis correlates with iron overload but not with HFE
   gene mutations in chronic hepatitis C
SO HEPATOBILIARY & PANCREATIC DISEASES INTERNATIONAL
LA English
DT Article
DE hepatitis C virus; iron overload; fatty liver; hemochromatosis;
   metabolic syndrome X
ID VIRUS CORE PROTEIN; INSULIN-RECEPTOR SUBSTRATE-1; AMINOTRANSFERASE
   LEVELS; OXIDATIVE STRESS; RESISTANCE; DISEASE; HEMOCHROMATOSIS;
   GENOTYPES; HCV; PATHOGENESIS
AB BACKGROUND: Liver steatosis and iron overload, which are frequently observed in chronic hepatitis C (CHC), may contribute to the progression of liver injury. This study aimed to evaluate the correlation between liver steatosis and iron overload in Polish patients with CHC compared to nonalcoholic fatty liver disease (NAFLD) and HFE-hereditary hemochromatosis (HH) patients.
   METHODS: A total of 191 CHC patients were compared with 67 NAFLD and 21 HH patients. Liver function tests, serum markers of iron metabolism, cholesterol and triglycerides were assayed. The inflammatory activity, fibrosis, iron deposits and steatosis stages were assessed in liver specimens. HFE gene polymorphisms were investigated by PCR-RFLP.
   RESULTS: Liver steatosis was associated with obesity and diabetes mellitus. This disease was confirmed in 76/174 (44%) CHC patients, most of whom were infected with genotype 1. The average grade of steatosis was higher in NAFLD patients. CHC patients had significantly higher iron concentrations and transferrin saturations than NAFLD patients. Compared with CHC patients, HH patients had higher values of serum iron parameters and more intensive hepatocyte iron deposits without differences in the prevalence and intensity of liver steatosis. In the CHC group, lipids accumulation in hepatocytes was significantly associated with the presence of serum markers of iron overload. No correlation between the HFE gene polymorphism and liver steatosis in CHC patients was found.
   CONCLUSIONS: Liver steatosis was diagnosed in nearly half of CHC patients, most of whom were infected with genotype 1. The intensity of steatosis was lower in CHC patients than that in NAFLD patients because of a less frequent diagnosis of metabolic syndrome. Only in CHC patients were biochemical markers of iron accumulation positively correlated with liver steatosis; these findings were independent of HFE gene mutations.
C1 [Sikorska, Katarzyna; Stalke, Piotr] Med Univ Gdansk, Dept Infect Dis, PL-80214 Gdansk, Poland.
   [Romanowski, Tomasz; Bielawski, Krzysztof Piotr] Univ Gdansk, Intercollegiate Fac Biotechnol, Dept Biotechnol, PL-80822 Gdansk, Poland.
   [Romanowski, Tomasz; Bielawski, Krzysztof Piotr] Med Univ Gdansk, PL-80822 Gdansk, Poland.
   [Rzepko, Robert] Med Univ Gdansk, Dept Pathol, PL-80952 Gdansk, Poland.
C3 Fahrenheit Universities; Medical University Gdansk; Fahrenheit
   Universities; University of Gdansk; Fahrenheit Universities; Medical
   University Gdansk; Fahrenheit Universities; Medical University Gdansk
RP Bielawski, KP (corresponding author), Univ Gdansk, Intercollegiate Fac Biotechnol, Dept Biotechnol, Kladki 24, PL-80822 Gdansk, Poland.
EM bielawski@biotech.ug.gda.pl
RI Stalke, Piotr/T-2486-2018; Bielawski, Krzysztof/D-8711-2011; Sikorska,
   Katarzyna/T-7829-2018
OI Stalke, Piotr/0000-0003-2747-6706; Bielawski, Krzysztof
   Piotr/0000-0002-5812-6314; Sikorska, Katarzyna/0000-0001-5678-5669
FU Medical University of Gdansk [W-175]
FX The study was supported by a grant from Medical University of Gdansk
   (W-175).
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NR 46
TC 11
Z9 12
U1 0
U2 9
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1499-3872
EI 2352-9377
J9 HEPATOB PANCREAT DIS
JI Hepatob. Pancreatic. Dis. Int.
PD AUG 15
PY 2013
VL 12
IS 4
BP 377
EP 384
DI 10.1016/S1499-3872(13)60059-4
PG 8
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 198MA
UT WOS:000322925800005
PM 23924495
DA 2025-06-11
ER

PT J
AU Banihashemi, N
   Robillard, R
   Yang, J
   Carpenter, JS
   Hermens, DF
   Naismith, SL
   Terpening, Z
   White, D
   Scott, EM
   Hickie, IB
AF Banihashemi, Nahid
   Robillard, Rebecca
   Yang, Jean
   Carpenter, Joanne S.
   Hermens, Daniel F.
   Naismith, Sharon L.
   Terpening, Zoe
   White, Django
   Scott, Elizabeth M.
   Hickie, Ian B.
TI Quantifying the effect of body mass index, age, and depression severity
   on 24-h activity patterns in persons with a lifetime history of
   affective disorders
SO BMC PSYCHIATRY
LA English
DT Article
DE Functional linear model; Multiple regression method; Body mass index;
   Actigraphy; Circadian activity pattern; Depression; Affective disorders
ID NUTRITION EXAMINATION SURVEY; MENTAL-HEALTH-SERVICES; DELAYED SLEEP
   PHASE; PHYSICAL-ACTIVITY; BIPOLAR DISORDER; NATIONAL-HEALTH; METABOLIC
   SYNDROME; CIRCADIAN-RHYTHMS; NORMAL-WEIGHT; ADULTS
AB Background: Patients with affective disorders of different ages have been found to present weight changes and different circadian activity patterns. This study assessed the effects of age, Body Mass Index (BMI) and depression severity on the activity-rest cycle in persons with affective disorders using a novel multifactorial 24-h analysis method.
   Methods: Two hundred and thirty-six participants aged between 14 and 85 years underwent 5 to 22 days of actigraphy monitoring (mean duration = 14 days). BMI was also recorded and symptom severity was assessed with the Hamilton Depression Rating Scale (HDRS). Participants were divided into two groups: healthy controls (n = 68) and participants with a lifetime diagnosis of affective disorders (n = 168). First, the multiple regression method was employed to formulate the circadian activity pattern in term of the factors age, BMI and HDRS. For each group, the functional linear analysis method was applied to assess the relative effects of the factors. Finally, Wald-tests were used to assess the contribution of each factor on the circadian activity pattern.
   Results: In the affective disorders group, higher BMI was associated with higher activity levels from 3 am until 5.30 am and with lower activity levels from 10 am until 10.30 pm. Older age was associated with less activity across the day, evening, and night - from 11 am until 5.30 am. Higher HDRS scores were associated with higher activity around 1: 30 am. In healthy controls, the effects of BMI and age on activity patterns were less pronounced and affected a narrower portion of the 24-h period.
   Conclusion: These findings suggest that older age and higher BMI are linked to lower daytime activity levels. Higher BMI and worse symptom severity were also associated with nocturnal activity patterns suggestive of sleep disturbances. The influence of age and BMI on 24-h activity profiles appear to be especially pronounced in people with affective disorders.
C1 [Robillard, Rebecca; Carpenter, Joanne S.; Hermens, Daniel F.; Naismith, Sharon L.; Terpening, Zoe; White, Django; Scott, Elizabeth M.; Hickie, Ian B.] Univ Sydney, Brain & Mind Ctr, Clin Res Unit, Camperdown, NSW, Australia.
   [Banihashemi, Nahid] Univ Sydney, Charles Perkins Ctr, Camperdown, NSW, Australia.
   [Yang, Jean] Univ Sydney, Sch Math & Stat, Camperdown, NSW, Australia.
C3 University of Sydney; University of Sydney; University of Sydney
RP Hickie, IB (corresponding author), Univ Sydney, Brain & Mind Ctr, Clin Res Unit, Camperdown, NSW, Australia.
EM ian.hickie@sydney.edu.au
RI Carpenter, Joanne/HZK-3629-2023; Robillard, Rebecca/G-9045-2017; Hickie,
   Ian/K-8975-2015; Yang, Jean/D-2920-2015
OI Hickie, Ian/0000-0001-8832-9895; Carpenter, Joanne/0000-0002-9766-6700;
   Scott, Elizabeth/0000-0003-3907-0324; Hermens,
   Daniel/0000-0002-8570-2663; Yang, Jean/0000-0002-5271-2603; Naismith,
   Sharon/0000-0001-9076-2778
FU National Health and Medical Research Council Program [566529];
   Australian Fellowship [464914]; NSW Health Mental Health and Drug
   Alcohol Office; National Health and Medical Research Council Clinical
   Development Award [1008117]; Fonds de la recherche en sante du Quebec;
   NHMRC Centre of Research Excellence in Optimising Early Interventions
   for Young People with Emerging Mood Disorders [1061043]
FX IBH was funded by a National Health and Medical Research Council Program
   Grant (No. 566529) and Australian Fellowship (No. 464914). DFH was
   supported by a grant from NSW Health Mental Health and Drug & Alcohol
   Office. SLN was funded by a National Health and Medical Research Council
   Clinical Development Award (No. 1008117). RR received a postdoctoral
   training award from the Fonds de la recherche en sante du Quebec. JSC
   was supported by the NHMRC Centre of Research Excellence in Optimising
   Early Interventions for Young People with Emerging Mood Disorders (No.
   1061043). The funders had no role in study design, data collection and
   analysis, decision to publish, or preparation of the manuscript.
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NR 55
TC 14
Z9 14
U1 0
U2 8
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-244X
J9 BMC PSYCHIATRY
JI BMC Psychiatry
PD SEP 9
PY 2016
VL 16
AR 317
DI 10.1186/s12888-016-1023-2
PG 11
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA DW1PT
UT WOS:000383415800001
PM 27612556
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Vitaliano, PP
   Zhang, JP
   Young, HM
   Caswell, LW
   Scanlan, JM
   Echeverria, D
AF Vitaliano, Peter P.
   Zhang, Jianping
   Young, Heather M.
   Caswell, Lisa W.
   Scanlan, James M.
   Echeverria, Diana
TI Depressed Mood Mediates Decline in Cognitive Processing Speed in
   Caregivers
SO GERONTOLOGIST
LA English
DT Article
DE Stress; Caregiving; Depression; Cognition; Processing speed; Attention
ID TEST-RETEST RELIABILITY; OLDER-ADULTS; RISK-FACTORS; DEMENTIA
   CAREGIVERS; MEMORY PERFORMANCE; METABOLIC SYNDROME; SPOUSE CAREGIVERS;
   FUNCTIONAL STATUS; PHYSICAL HEALTH; CHRONIC STRESS
AB Purpose: Very few studies have examined cognitive decline in caregivers versus noncaregivers, and only 1 study has examined mediators of such decline. We evaluated the relationship between caregiver status and decline on the digit symbol test (DST, a measure of processing speed, attention, cognitive-motor translation, and visual scanning) and whether this relationship was mediated by depressed mood. Design and Methods: Caregivers for spouses with Alzheimer's disease (n = 122) were compared with demographically similar noncaregiver spouses (n = 117) at study entry (Time 1 = T1), T2 (1 year later), and T3 (2 years after T1). Results: Caregivers had lower DST scores and higher Hamilton depression scores at T1, T2, and T3 than noncaregivers (all p < .05). Hierarchical linear modeling revealed that although caregivers started well below noncaregivers, they experienced a more rapid rate of decline than noncaregivers (p = .047). Caregivers declined 4.5 times faster than noncaregivers. Greater depressed mood at T1 (p < .01) and T2 (p < .01) predicted DST decline and mediated DST decline in caregivers vs. noncaregivers. Implications: Depressed mood in caregivers relative to noncaregivers may influence their greater risk for DST decline. This is important because the DST predicts problem solving and everyday functions necessary for independent living and the potential well-being of their care recipients.
C1 [Vitaliano, Peter P.; Scanlan, James M.] Univ Washington, Seattle, WA 98195 USA.
   [Zhang, Jianping] Zucker Hillside Hosp, N Shore Long Isl Jewish Hlth Syst, Dept Psychiat, Glen Oaks, NY USA.
   [Young, Heather M.] Univ Calif Davis Hlth Syst, Betty Irene Moore Sch Nursing, Sacramento, CA USA.
   [Caswell, Lisa W.] St Martins Univ, Lacey, WA USA.
   [Echeverria, Diana] Battelle Ctr Hlth Res, Seattle, WA USA.
C3 University of Washington; University of Washington Seattle; Northwell
   Health; University of California System; University of California Davis
RP Vitaliano, PP (corresponding author), Univ Washington, Box 356560, Seattle, WA 98195 USA.
EM pvital@u.washington.edu
RI Vitaliano, Peter/K-2014-2019; Young, Heather/JBS-7552-2023; Zhang,
   Jian-Ping/L-9805-2016
OI Vitaliano, peter P./0000-0003-1598-0868; Zhang,
   Jian-Ping/0000-0001-6363-6362
FU NCRR NIH HHS [M01-RR000] Funding Source: Medline; NIDDK NIH HHS
   [DK38516] Funding Source: Medline; NIMH NIH HHS [R01 MH57663] Funding
   Source: Medline
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NR 80
TC 73
Z9 91
U1 0
U2 23
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0016-9013
EI 1758-5341
J9 GERONTOLOGIST
JI Gerontologist
PD FEB
PY 2009
VL 49
IS 1
BP 12
EP 22
DI 10.1093/geront/gnp004
PG 11
WC Gerontology
WE Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA 433BC
UT WOS:000265177400002
PM 19363000
OA Green Published
DA 2025-06-11
ER

PT J
AU Li, YJ
   Wu, YL
   Zhai, L
   Wang, T
   Sun, YY
   Zhang, DF
AF Li, Yujie
   Wu, Yili
   Zhai, Long
   Wang, Tong
   Sun, Yongye
   Zhang, Dongfeng
TI Longitudinal Association of Sleep Duration with Depressive Symptoms
   among Middle-aged and Older Chinese
SO SCIENTIFIC REPORTS
LA English
DT Article
ID LATE-LIFE DEPRESSION; CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; NAP
   DURATION; INSOMNIA; ADULTS; RISK; ANXIETY; DISTURBANCES; COHORT
AB This study aimed to evaluate the associations of nighttime sleep duration and midday napping with risk of depressive symptoms incidence and persistence among middle-aged and older Chinese. Data from China Health and Retirement Longitudinal Study, CHARLS (2011-2013), were analyzed. Depressive symptoms were identified by the 10-item version of the Centre for Epidemiological Studies Depression scale (CESD-10). Multivariate binary logistic regression models were fitted. There were 7156 individuals with CESD-10 scores < 10 and 3896 individuals with CESD-10 scores >= 10 at baseline included in this study. After controlling for potential covariates, nighttime sleep duration < 6 hours was associated with high risk of incident depressive symptoms (OR = 1.450, 95% CI: 1.193, 1.764 for middle aged population, and OR = 2.084, 95% CI: 1.479, 2.936 for elderly) and persistent depressive symptoms (OR = 1.404, 95% CI: 1.161, 1.699 for middle aged population, and OR = 1.365, 95% CI: 0.979, 1.904 for elderly). For depressed individuals, longer midday napping (>= 60 minutes) was associated with lower persistent depressive symptoms (OR = 0.842, 95% CI: 0.717, 0.989). Our study concluded that short nighttime sleep duration was an independent risk factor of depressive symptoms incidence and persistence. Depressed individuals with long midday napping were more likely to achieve reversion than those who have no siesta habit.
C1 [Li, Yujie; Wu, Yili; Wang, Tong; Zhang, Dongfeng] Qingdao Univ, Med Coll, Dept Epidemiol & Hlth Stat, Qingdao, Peoples R China.
   [Zhai, Long] Qingdao Ctr Dis Control & Prevent, Qingdao, Peoples R China.
   [Sun, Yongye] Qingdao Univ, Med Coll, Dept Nutr & Food Hyg, Qingdao, Peoples R China.
C3 Qingdao University; Qingdao University
RP Wu, YL (corresponding author), Qingdao Univ, Med Coll, Dept Epidemiol & Hlth Stat, Qingdao, Peoples R China.
EM yiliwu79@163.com
RI Wang, Tong/HII-8818-2022
FU National Natural Science Foundation of China [31371024]
FX The authors appreciate the Chinese CDC for making the survey and making
   it available online freely, and all the participants for providing these
   data. This research project was supported by grants from the National
   Natural Science Foundation of China (31371024).
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NR 36
TC 71
Z9 75
U1 11
U2 78
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD SEP 18
PY 2017
VL 7
AR 11794
DI 10.1038/s41598-017-12182-0
PG 7
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Science & Technology - Other Topics
GA FH1RJ
UT WOS:000410916800008
PM 28924238
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Li, YN
   Buys, N
   Li, L
   Sun, J
AF Li, Yanni
   Buys, Nicholas
   Li, Li
   Sun, Jing
TI Sleep Quality and Its Determinants Among Type 2 Diabetes Patients with
   Comorbid Metabolic Syndrome
SO DIABETES METABOLIC SYNDROME AND OBESITY
LA English
DT Article
DE type 2 diabetes; sleep quality; sleep latency; sleep duration; sleep
   efficiency; influence factor
ID OF-LIFE; MELLITUS; DISTURBANCES; MELATONIN; HEALTH; QUESTIONNAIRE;
   ASSOCIATION; RELIABILITY; DEFINITION; DEPRESSION
AB Purpose: The prevalence of poor sleep quality in patients with diabetes was higher than the general population. This study aimed to explore risk factors for not only poor sleep quality, but also long sleep latency, short sleep duration and low sleep efficiency, in type 2 diabetes patients (T2DM) with comorbid metabolic syndrome (MS). Patients and Methods: A total of 281 patients aged 18-75 years were enrolled from Ningbo First Hospital during October 2021 to March 2022. Sleep quality was evaluated by the Pittsburgh Sleep Quality Index (PSQI). Sleep latency, sleep duration and sleep efficiency were obtained by a response to the questionnaire. Descriptive, independent two-sample t-test, Chi-square test and multiple logistic regression were conducted using SPSS Version 28.Results: The prevalence of poor sleep quality in T2DM with comorbid MS patients was 59.10%. The factors significantly associated with poor sleep quality were depression symptoms (OR = 3.10, 95% CI: 1.38 to 6.96, P = 0.006), poor quality of life (OR = 2.49, 95% CI: 1.24 to 4.99, P = 0.010), and age (OR = 1.07, 95% CI: 1.04 to 1.10, P < 0.001). The factor significantly associated with long sleep latency was depression symptoms (OR = 2.19, 95% CI: 1.15 to 4.16, P = 0.017). The factors significantly related to short sleep duration were depression symptoms (OR = 2.56, 95% CI: 1.31 to 5.00, P = 0.006) and age (OR = 1.05, 95% CI: 1.02 to 1.08, P = 0.002). The factor significantly related to short sleep efficiency was age (OR = 1.03, 95% CI: 1.01 to 1.06, P = 0.019).Conclusion: This study found that depression symptoms, together with poor quality of life, and increasing age were associated with poor sleep quality. Symptoms of depression were related to long sleep latency and short sleep duration. The increasing age was associated with short sleep duration and low sleep efficiency.
C1 [Li, Yanni; Sun, Jing] Griffith Univ, Sch Med & Dent, Q422, Gold Coast, Qld, Australia.
   [Buys, Nicholas; Sun, Jing] Griffith Univ, Inst Integrated Intelligence & Syst, Q4215, Gold Coast, Qld, Australia.
   [Li, Li] Ningbo First Hosp, Dept Endocrinol & Metab, Ningbo 315010, Zhejiang, Peoples R China.
   [Sun, Jing] Griffith Univ, Sch Med & Dent, G40 8 23 Q4222, Gold Coast, Qld, Australia.
C3 Griffith University; Griffith University - Gold Coast Campus; Griffith
   University; Griffith University - Gold Coast Campus; Ningbo University;
   Griffith University; Griffith University - Gold Coast Campus
RP Li, L (corresponding author), Ningbo First Hosp, Dept Endocrinol & Metab, Ningbo 315010, Zhejiang, Peoples R China.; Sun, J (corresponding author), Griffith Univ, Sch Med & Dent, G40 8 23 Q4222, Gold Coast, Qld, Australia.
EM lilyningbo@163.com; j.sun@griffith.edu.au
RI Buys, Nicholas/AAT-3925-2020; Sun, Jing/AAS-1582-2020
OI Sun, Jing/0000-0002-0097-2438; Buys, Nicholas/0000-0002-4780-8088
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NR 47
TC 2
Z9 2
U1 0
U2 9
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-7007
J9 DIABET METAB SYND OB
JI Diabetes Metab. Syndr. Obes.
PY 2022
VL 15
BP 3469
EP 3482
DI 10.2147/DMSO.S386299
PG 14
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 6E4ZN
UT WOS:000883390000001
PM 36388064
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Schäfer, I
   von Leitner, EC
   Schön, G
   Koller, D
   Hansen, H
   Kolonko, T
   Kaduszkiewicz, H
   Wegscheider, K
   Glaeske, G
   van den Bussche, H
AF Schaefer, Ingmar
   von Leitner, Eike-Christin
   Schoen, Gerhard
   Koller, Daniela
   Hansen, Heike
   Kolonko, Tina
   Kaduszkiewicz, Hanna
   Wegscheider, Karl
   Glaeske, Gerd
   van den Bussche, Hendrik
TI Multimorbidity Patterns in the Elderly: A New Approach of Disease
   Clustering Identifies Complex Interrelations between Chronic Conditions
SO PLOS ONE
LA English
DT Article
ID METABOLIC SYNDROME; RISK PROFILE; POPULATION; PREVALENCE; SYMPTOMS;
   DEPRESSION; DEMENTIA; ANXIETY; COMORBIDITY; STROKE
AB Objective: Multimorbidity is a common problem in the elderly that is significantly associated with higher mortality, increased disability and functional decline. Information about interactions of chronic diseases can help to facilitate diagnosis, amend prevention and enhance the patients' quality of life. The aim of this study was to increase the knowledge of specific processes of multimorbidity in an unselected elderly population by identifying patterns of statistically significantly associated comorbidity.
   Methods: Multimorbidity patterns were identified by exploratory tetrachoric factor analysis based on claims data of 63,104 males and 86,176 females in the age group 65+. Analyses were based on 46 diagnosis groups incorporating all ICD-10 diagnoses of chronic diseases with a prevalence >= 1%. Both genders were analyzed separately. Persons were assigned to multimorbidity patterns if they had at least three diagnosis groups with a factor loading of 0.25 on the corresponding pattern.
   Results: Three multimorbidity patterns were found: 1) cardiovascular/metabolic disorders [prevalence female: 30%; male: 39%], 2) anxiety/depression/somatoform disorders and pain [34%; 22%], and 3) neuropsychiatric disorders [6%; 0.8%]. The sampling adequacy was meritorious (Kaiser-Meyer-Olkin measure: 0.85 and 0.84, respectively) and the factors explained a large part of the variance (cumulative percent: 78% and 75%, respectively). The patterns were largely age-dependent and overlapped in a sizeable part of the population. Altogether 50% of female and 48% of male persons were assigned to at least one of the three multimorbidity patterns.
   Conclusion: This study shows that statistically significant co-occurrence of chronic diseases can be subsumed in three prevalent multimorbidity patterns if accounting for the fact that different multimorbidity patterns share some diagnosis groups, influence each other and overlap in a large part of the population. In recognizing the full complexity of multimorbidity we might improve our ability to predict needs and achieve possible benefits for elderly patients who suffer from multimorbidity.
C1 [Schaefer, Ingmar; von Leitner, Eike-Christin; Hansen, Heike; Kolonko, Tina; Kaduszkiewicz, Hanna; van den Bussche, Hendrik] Univ Med Ctr Hamburg Eppendorf, Dept Primary Med Care, Hamburg, Germany.
   [Schoen, Gerhard; Wegscheider, Karl] Univ Med Ctr Hamburg Eppendorf, Dept Med Biometry & Epidemiol, Hamburg, Germany.
   [Koller, Daniela; Glaeske, Gerd] Univ Bremen, Div Hlth Econ Hlth Policy & Hlth Serv Res, Ctr Social Policy Res, Bremen, Germany.
C3 University of Hamburg; University Medical Center Hamburg-Eppendorf;
   University of Hamburg; University Medical Center Hamburg-Eppendorf;
   University of Bremen
RP Schäfer, I (corresponding author), Univ Med Ctr Hamburg Eppendorf, Dept Primary Med Care, Hamburg, Germany.
EM in.schaefer@uke.uni-hamburg.de
RI Koller, Daniela/HKW-2352-2023
OI Koller, Daniela/0000-0002-3203-7188
FU German Federal Ministry of Education and Research [01ET0725, 01ET0731]
FX The study was funded by the German Federal Ministry of Education and
   Research (http://www.bmbf.bund.de/; grant numbers 01ET0725 and
   01ET0731). The funders had no role in study design, data collection and
   analysis, decision to publish, or preparation of the manuscript.
CR [Anonymous], 2007, WISSENSCHAFTLICHES G
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NR 34
TC 124
Z9 141
U1 3
U2 57
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD DEC 29
PY 2010
VL 5
IS 12
AR e15941
DI 10.1371/journal.pone.0015941
PG 10
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Science & Technology - Other Topics
GA 701CZ
UT WOS:000285793200075
PM 21209965
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Korniloff, K
   Kotiaho, S
   Vanhala, M
   Kautiainen, H
   Koponen, H
   Mäntyselkä, P
AF Korniloff, Katariina
   Kotiaho, Satu
   Vanhala, Mauno
   Kautiainen, Hannu
   Koponen, Hannu
   Mantyselka, Pekka
TI Musculoskeletal Pain in Melancholic and Atypical Depression
SO PAIN MEDICINE
LA English
DT Article
DE Depression Characteristics; Depressive Disorder; Musculoskeletal Pain
ID METABOLIC SYNDROME; PREVALENCE; DISORDER; UNIQUE
AB Objective. Pain and depressive disorders often present together, but little is known about the prevalence of pain in depression subgroups. The objective of this study was to examine the possible differences in the prevalence of musculoskeletal pain between participants in melancholic and atypical depression subgroups.
   Design. Cross-sectional study.
   Setting. Depression nurse case managers where depression patients receive treatment in primary health care.
   Subjects. Participants included 413 depression patients and 401 controls.
   Methods. Depressive symptoms were determined with the Beck Depression Inventory (BDI-21), and diagnosis of depression was confirmed with the Mini-International Neuropsychiatric Interview (MINI). The participants were dichotomized into subgroups with melancholic depression (n=269), atypical depression (n=144), and controls (n=401). Musculoskeletal pain was identified during last four weeks. Participants were enrolled in the study between 2008 and 2009.
   Results. The prevalence of pain was 37% in controls, 57% in atypical depression, and 71% in melancholic depression (P < 0.001, after adjusting for sex and age). A logistic regression model showed that the odds ratio of pain after adjusting for confounding factors was 2.35 (1.56 to 3.56) with atypical depression compared with controls P < 0.001) and 4.38 (3.03 to 6.33) with melancholic depression compared with atypical depression (P=0.006). BDI scores were higher for those with melancholic depression than for those with atypical depression (P < 0.001).
   Conclusions. Melancholic depression showed to be associated with a higher prevalence of musculoskeletal pain in comparison with atypical depression. This finding highlights the need for further studies about the mechanisms behind the association, particularly in melancholic depression.
C1 [Korniloff, Katariina] Univ Jyvaskyla, Dept Hlth Sci, POB 35,Fi-40014, SF-40351 Jyvaskyla, Finland.
   [Kotiaho, Satu] Saarikka Primary Care Publ Util, Saarijarvi, Finland.
   [Vanhala, Mauno; Mantyselka, Pekka] Cent Finland Cent Hosp, Primary Hlth Care Unit, Jyvaskyla, Finland.
   [Vanhala, Mauno] Univ Eastern Finland, Primary Hlth Care Unit, Kuopio, Finland.
   [Vanhala, Mauno; Kautiainen, Hannu] Kuopio Univ Hosp, Primary Hlth Care Unit, Kuopio, Finland.
   [Kautiainen, Hannu] Helsinki Univ Cent Hosp, Unit Primary Hlth Care, Helsinki, Finland.
   [Kautiainen, Hannu] Univ Helsinki, Dept Gen Practice, Helsinki, Finland.
   [Koponen, Hannu] Univ Helsinki, Dept Psychiat, Helsinki, Finland.
   [Koponen, Hannu] Helsinki Univ Hosp, Helsinki, Finland.
C3 University of Jyvaskyla; Central Finland Central Hospital; University of
   Eastern Finland; Kuopio University Hospital; University of Eastern
   Finland; University of Eastern Finland Hospital; University of Helsinki;
   Helsinki University Central Hospital; University of Helsinki; University
   of Helsinki; University of Helsinki; Helsinki University Central
   Hospital
RP Korniloff, K (corresponding author), Univ Jyvaskyla, Dept Hlth Sci, POB 35,Fi-40014, SF-40351 Jyvaskyla, Finland.
EM katariina.korniloff@jyu.fi
OI Korniloff, Katariina/0000-0002-0753-1483; Koponen,
   Hannu/0000-0002-7368-1869
FU Central Finland Health Care District; Yrjo Jahnsson Foundation
FX The study was supported by the Central Finland Health Care District and
   Yrjo Jahnsson Foundation.
CR [Anonymous], 1998, INTRO BOOTSTRAP
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NR 26
TC 10
Z9 11
U1 0
U2 6
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1526-2375
EI 1526-4637
J9 PAIN MED
JI Pain Med.
PD FEB
PY 2017
VL 18
IS 2
BP 341
EP 347
DI 10.1093/pm/pnw202
PG 7
WC Anesthesiology; Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Anesthesiology; General & Internal Medicine
GA EP0VB
UT WOS:000397103700016
PM 28204727
OA Bronze
DA 2025-06-11
ER

PT J
AU Godin, O
   Leboyer, M
   Schürhoff, F
   Boyer, L
   Andrianarisoa, M
   Brunel, L
   Bulzacka, E
   Aouizerate, B
   Berna, F
   Capdevielle, D
   D'Amato, T
   Denizot, H
   Dubertret, C
   Dubreucq, J
   Faget, C
   Gabayet, F
   Llorca, PM
   Mallet, J
   Misdrahi, D
   Passerieux, C
   Rey, R
   Richieri, R
   Schandrin, A
   Urbach, M
   Vidailhet, P
   Costagliola, D
   Fond, G
AF Godin, O.
   Leboyer, M.
   Schurhoff, F.
   Boyer, L.
   Andrianarisoa, M.
   Brunel, L.
   Bulzacka, E.
   Aouizerate, B.
   Berna, F.
   Capdevielle, D.
   D'Amato, T.
   Denizot, H.
   Dubertret, C.
   Dubreucq, J.
   Faget, C.
   Gabayet, F.
   Llorca, P. M.
   Mallet, J.
   Misdrahi, D.
   Passerieux, C.
   Rey, R.
   Richieri, R.
   Schandrin, A.
   Urbach, M.
   Vidailhet, P.
   Costagliola, D.
   Fond, G.
CA FACE-SZ FondaMental Acad Ctr
TI Predictors of rapid high weight gain in schizophrenia: Longitudinal
   analysis of the French FACE-SZ cohort
SO JOURNAL OF PSYCHIATRIC RESEARCH
LA English
DT Article
DE Schizophrenia; Metabolic syndrome; Risk factors; Weight gain; Depression
ID C-REACTIVE PROTEIN; PSYCHIATRY WFSBP GUIDELINES; MAJOR DEPRESSIVE
   DISORDER; METABOLIC RISK-FACTORS; BIPOLAR DISORDER; ATYPICAL
   ANTIPSYCHOTICS; BIOLOGICAL TREATMENT; SPECTRUM DISORDERS; WORLD
   FEDERATION; RATING-SCALE
AB Metabolic syndrome (MetS) is highly prevalent in schizophrenia. However very little is known about the time course of MetS and its components. The few longitudinal studies that have been carried out had small sample sizes and a short follow-up. The aim of our study was to evaluate the prevalence of MetS and its components, at baseline and one year later, and to investigate predictors of weight gain (WG) in a cohort of individuals with schizophrenia. We followed 167 schizophrenia patients from the FACE-SZ cohort for one year. The Structured Clinical Interview for DSM-IV (SCID) was used to confirm the diagnosis of schizophrenia. Data on socio-demographic and clinical characteristics, antipsychotic treatment, and comorbidities were collected, and a blood sample was drawn.
   We found that the prevalence of MetS increased from 21.0% to 26.6% after one year. Patients with baseline depressive symptoms had a 4.5-fold higher risk of WG at the one-year follow-up (p = 0.02) than those without depressive symptoms, after adjusting for confounding variables. WG also correlated with high levels of metabolic parameters and peripheral inflammation. These findings highlight the need to systematically diagnose depression in Schizophrenia. Future studies should determine whether specific pharmacological and non-pharmacological interventions for depression in SZ subjects are effective in preventing rapid high weight gain. (C) 2017 Elsevier Ltd. All rights reserved.
C1 [Godin, O.; Leboyer, M.; Schurhoff, F.; Boyer, L.; Andrianarisoa, M.; Brunel, L.; Bulzacka, E.; Aouizerate, B.; Berna, F.; Capdevielle, D.; D'Amato, T.; Denizot, H.; Dubertret, C.; Dubreucq, J.; Faget, C.; Gabayet, F.; Llorca, P. M.; Mallet, J.; Misdrahi, D.; Passerieux, C.; Rey, R.; Richieri, R.; Schandrin, A.; Urbach, M.] Fondat FondaMental, F-94010 Creteil, France.
   [Leboyer, M.; Schurhoff, F.; Andrianarisoa, M.; Brunel, L.; Bulzacka, E.; Fond, G.] INSERM U955, Equipe Psychiat Translationnelle, Creteil, France.
   [Leboyer, M.; Schurhoff, F.; Andrianarisoa, M.; Brunel, L.; Bulzacka, E.; Fond, G.] Univ Paris Est Creteil, DHU PePSY, Pole Psychiat Hop Univ H Mondor, F-94000 Creteil, France.
   [Boyer, L.] Pole Psychiat Univ, CHU St Marguerite, F-13274 Marseille 09, France.
   [Aouizerate, B.; Misdrahi, D.] Univ Bordeaux, Ctr Hosp Charles Perrens, F-33076 Bordeaux, France.
   [Berna, F.; Vidailhet, P.] Univ Strasbourg, Hop Univ Strasbourg, INSERM U1114, Federat Med Translationnelle Strasbourg, Strasbourg, France.
   [Capdevielle, D.; Schandrin, A.] Univ Montpellier I, INSERM, CHRU Montpellier, Hop Colombiere,Serv Univ Psychiat Adulte, F-1061 Montpellier, France.
   [Denizot, H.; Llorca, P. M.] Univ Auvergne, EA Fac Med 7280, CHU, CMP B, BP 69, F-630031 Clermont Ferrand 1, France.
   [D'Amato, T.; Rey, R.] Univ Claude Bernard Lyon 1, Ctr Hosp Vinatier, Equipe PSYR2, Ctr Rech Neurosci Lyon,INSERM U1028,CNRS UMR5292, 95 Bd Pinel,BP 30039, F-69678 Bron, France.
   [Dubertret, C.; Mallet, J.] Univ Paris Diderot, Fac Med, Sorbonne Paris Cite,AP HP, INSERM U894,Louis Mourier Hosp,Dept Psychiat, Paris, France.
   [Dubreucq, J.; Gabayet, F.] CH Alpes Isere, Ctr Referent Rehabil Psychosociale, Grenoble, France.
   [Faget, C.; Richieri, R.] Pole Univ Psychiat, AP HM, Marseille, France.
   [Passerieux, C.; Urbach, M.] Univ Versailles St Quentin Yvelines, UFR Sci St Simone Veil, Ctr Hosp Versailles, Serv Psychiat Adulte, Versailles, France.
   [Aouizerate, B.; Misdrahi, D.] Bordeaux Univ, Pellegrin Univ Hosp, USR CNRS SANPSY 3413, Res Unit,Pellegrin Univ Hosp,Bordeaux Sleep Clin, F-33000 Bordeaux, France.
   [Aouizerate, B.] INSERM, Neuroctr Magendie, Physiopathol Plasticite Neuronale, U862, F-33000 Bordeaux, France.
   [Misdrahi, D.] CNRS, UMR 5287, INCIA, Bordeaux, France.
   [Costagliola, D.] Sorbonne Univ, UPMC Univ Paris 06, INSERM, Inst Pierre Louis Epidemiol & St Publ IPLESP UMRS, F-75013 Paris, France.
C3 Institut National de la Sante et de la Recherche Medicale (Inserm);
   Universite Paris-Est-Creteil-Val-de-Marne (UPEC); Assistance Publique
   Hopitaux Paris (APHP); Universite Paris-Est-Creteil-Val-de-Marne (UPEC);
   Hopital Universitaire Henri-Mondor - APHP; Aix-Marseille Universite;
   Universite de Bordeaux; CHU Strasbourg; Universites de Strasbourg
   Etablissements Associes; Universite de Strasbourg; Institut National de
   la Sante et de la Recherche Medicale (Inserm); Universite de
   Montpellier; CHU de Montpellier; Institut National de la Sante et de la
   Recherche Medicale (Inserm); Universite Clermont Auvergne (UCA); CHU
   Clermont Ferrand; Centre National de la Recherche Scientifique (CNRS);
   Institut National de la Sante et de la Recherche Medicale (Inserm);
   Universite Claude Bernard Lyon 1; Universite Jean Monnet; CNRS -
   National Institute for Biology (INSB); Universite Paris Cite; Institut
   National de la Sante et de la Recherche Medicale (Inserm); Assistance
   Publique Hopitaux Paris (APHP); Hopital Universitaire Louis-Mourier -
   APHP; Aix-Marseille Universite; Assistance Publique-Hopitaux de
   Marseille; Universite Paris Saclay; Centre Hospitalier de Versailles;
   CHU Bordeaux; Centre National de la Recherche Scientifique (CNRS); CNRS
   - National Institute for Biology (INSB); Universite de Bordeaux;
   Institut National de la Sante et de la Recherche Medicale (Inserm);
   Universite de Bordeaux; Centre National de la Recherche Scientifique
   (CNRS); CNRS - National Institute for Biology (INSB); Universite de
   Bordeaux; Institut National de la Sante et de la Recherche Medicale
   (Inserm); Sorbonne Universite
RP Godin, O (corresponding author), IPLESP, Hop Salpetriere, INSERM UMRS 1136, F-75651 Paris 13, France.
EM ophelia.godin@upmc.fr
RI Capdevielle, Delphine/HTO-4229-2023; Berna, Fabrice/J-2701-2019;
   Leboyer, Marion/AAW-3648-2021; Fond, Guillaume/D-7646-2011; Schandrin,
   Aurélie/ISV-4608-2023; richieri, raphaelle/E-4707-2015; Mallet,
   Jasmina/GNP-7160-2022; Boyer, Laurent/E-5728-2016; Costagliola,
   Dominique/H-5849-2011; TESSIER, Arnaud/A-4022-2017
OI Misdrahi, David/0000-0003-1146-3206; LEBOYER,
   Marion/0000-0001-5473-3697; Capdevielle, Delphine/0000-0002-7146-8554;
   D'Amato, Thierry/0000-0001-8983-0315; dubreucq,
   julien/0000-0003-4079-4194; Costagliola, Dominique/0000-0003-0765-0869;
   TESSIER, Arnaud/0000-0001-5758-5693; Aouizerate,
   Bruno/0000-0002-7092-7747; RICHIERI, Raphaelle/0000-0002-3901-7016
CR ADDINGTON D, 1990, SCHIZOPHR RES, V3, P247, DOI 10.1016/0920-9964(90)90005-R
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NR 54
TC 17
Z9 17
U1 0
U2 11
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-3956
EI 1879-1379
J9 J PSYCHIATR RES
JI J. Psychiatr. Res.
PD NOV
PY 2017
VL 94
BP 62
EP 69
DI 10.1016/j.jpsychires.2017.06.008
PG 8
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA FJ7TD
UT WOS:000412960900009
PM 28668717
DA 2025-06-11
ER

PT J
AU Carillon, J
   Knabe, L
   Montalban, A
   Stévant, M
   Keophiphath, M
   Lacan, D
   Cristol, JP
   Rouanet, JM
AF Carillon, Julie
   Knabe, Lucie
   Montalban, Anne
   Stevant, Marie
   Keophiphath, Mayoura
   Lacan, Dominique
   Cristol, Jean-Paul
   Rouanet, Jean-Max
TI Curative diet supplementation with a melon superoxide dismutase reduces
   adipose tissue in obese hamsters by improving insulin sensitivity
SO MOLECULAR NUTRITION & FOOD RESEARCH
LA English
DT Article
DE Adipocyte; Endogenous antioxidant defence; Insulin resistance;
   Lipolysis; Oxidative stress
ID OXIDATIVE STRESS; METABOLIC SYNDROME; MOLECULAR-MECHANISMS;
   LIPID-PEROXIDATION; CAFETERIA DIET; RISK FACTOR; FAT; RESISTANCE;
   EXPRESSION; INFLAMMATION
AB ScopeObesity-related metabolic syndrome is often associated with a decrease of insulin sensitivity, inducing several modifications. However, dietary antioxidants could prevent insulin resistance. We have previously shown the preventive effects of a melon superoxide dismutase (SOD) in obese hamsters. However, its antioxidant effects have never been studied on adipose tissue.
   Methods and resultsWe evaluated the effects of a 1-month curative supplementation with SODB on the adipose tissue of obese hamsters. Animals received either a standard diet or a cafeteria diet for 15 wk. Cafeteria diet induced obesity and related disorders, including insulin resistance and oxidative stress, in the abdominal adipose tissue. After SODB supplementation, the adipose tissue weight was decreased, probably by activating adipocytes lipolysis and thus reducing their size. SODB treatment also resulted in abdominal adipose tissue fibrosis reduction. Finally, SODB administration increased the expression of endogenous antioxidant enzymes and thus reduced oxidative stress and insulin resistance. The improvement of insulin sensitivity observed after SODB treatment could explain adipocyte lipolysis activation and fibrosis reduction.
   ConclusionThese findings demonstrate that a dietary SOD supplementation could be a useful strategy against obesity-related modifications in adipose tissue.
C1 [Carillon, Julie; Knabe, Lucie; Montalban, Anne; Cristol, Jean-Paul; Rouanet, Jean-Max] Univ Montpellier Sud France, UMR NutriPass 204, Prevent Malnutr & Pathol Associees, F-34090 Montpellier, France.
   [Stevant, Marie; Keophiphath, Mayoura] AdipoPhYt SAS, Paris, France.
   [Carillon, Julie; Lacan, Dominique] Bionov Sarl, Avignon, France.
   [Cristol, Jean-Paul] CHU Montpellier, Dept Biochim, Montpellier, France.
C3 Institut de Recherche pour le Developpement (IRD); Universite de
   Montpellier; Universite de Montpellier; CHU de Montpellier
RP Rouanet, JM (corresponding author), Univ Montpellier Sud France, UMR NutriPass 204, Pl Eugene Bataillon, F-34090 Montpellier, France.
EM jm.rouanet@univ-montp2.fr
OI , Lucie/0000-0003-4560-4273
FU CIFRE grant from Bionov (Avignon, France) [0417/2010]; French
   "Association Nationale de la Recherche et de la Technologie"
FX Julie Carillon was supported by a "CIFRE grant" (Convention Industrielle
   de Formation par la REcherche, no 0417/2010) from Bionov (Avignon,
   France) and the French "Association Nationale de la Recherche et de la
   Technologie".
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NR 55
TC 16
Z9 17
U1 0
U2 12
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1613-4125
EI 1613-4133
J9 MOL NUTR FOOD RES
JI Mol. Nutr. Food Res.
PD APR
PY 2014
VL 58
IS 4
BP 842
EP 850
DI 10.1002/mnfr.201300466
PG 9
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA AF2DA
UT WOS:000334521600018
PM 24255021
DA 2025-06-11
ER

PT J
AU Monda, M
   Messina, G
   Scognamiglio, I
   Lombardi, A
   Martin, GA
   Sperlongano, P
   Porcelli, M
   Caraglia, M
   Stiuso, P
AF Monda, Marcellino
   Messina, Giovanni
   Scognamiglio, Ilaria
   Lombardi, Angela
   Martin, Giuseppe A.
   Sperlongano, Pasquale
   Porcelli, Marina
   Caraglia, Michele
   Stiuso, Paola
TI Short-Term Diet and Moderate Exercise in Young Overweight Men Modulate
   Cardiocyte and Hepatocarcinoma Survival by OxidativeL Stress
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Article
ID HEPATOCELLULAR-CARCINOMA; RISK-FACTOR; EXPRESSION
AB The present study was designed to evaluate the effects of diet lifestyle on extending lifespan and reducing liver cancer risk. Young overweight men (n = 20), without metabolic syndrome, were placed in a 3-week residential program on a low-fat diet and moderate aerobic exercise. In each subject, pre- and postintervention fasting blood were collected for evaluating levels of serum lipids, and oxidative stress markers. Using subject sera and cardiomyocyte (H9C2) culture systems, we measured heat shock protein 27 and 90 expression, lipid accumulation, and oxidative stress marker levels. After 3-weeks of diet, significant reductions (P < 0.05) in body mass index, serum lipids and lipid ratios, and oxidative markers were recorded. In vitro, we observed that the addition of postintervention sera increased H9C2 cell number and reduced HSP27 and 90 expression, mitochondrial superoxide anion, and lipid accumulation with a parallel increase in nitric oxide (NO) production (all P < 0.01). At the same time, postintervention sera decreased human liver hepatocellular carcinoma cell line (HepG-2) proliferation, lipid accumulation, oxidative stress, and extracellular-signal-regulated kinases (ERK1/2) activity. Lifestyle modification in young overweight men, without metabolic syndrome, could ameliorate cardiocyte survival and reduce hepatocellular carcinoma cell proliferation.
C1 [Monda, Marcellino; Messina, Giovanni] Univ Naples 2, Dept Expt Med, I-80138 Naples, Italy.
   [Scognamiglio, Ilaria; Lombardi, Angela; Porcelli, Marina; Caraglia, Michele; Stiuso, Paola] Univ Naples 2, Dept Biochem Biophys & Gen Pathol, I-80138 Naples, Italy.
   [Martin, Giuseppe A.] Univ Naples Federico II, Dept Vet Med & Anim Reprod, I-80137 Naples, Italy.
   [Sperlongano, Pasquale] Univ Naples 2, Sch Med, Unit Gen & Geriatr Surg, I-80137 Naples, Italy.
C3 Universita della Campania Vanvitelli; Universita della Campania
   Vanvitelli; University of Naples Federico II; Universita della Campania
   Vanvitelli
RP Stiuso, P (corresponding author), Univ Naples 2, Dept Biochem Biophys & Gen Pathol, I-80138 Naples, Italy.
EM paola.stiuso@unina2.it
RI Caraglia, Michele/AFY-9729-2022; Messina, Giovanni/AAE-8668-2022;
   Caraglia, Michele/N-5670-2015
OI LOMBARDI, ANGELA/0000-0001-5421-9970; Messina,
   Antonietta/0000-0001-8343-432X; Stiuso, Paola/0000-0001-5096-7488;
   Messina, Giovanni/0000-0002-1730-7063; Monda,
   Marcellino/0000-0002-7184-218X; Caraglia, Michele/0000-0003-2408-6091
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NR 20
TC 60
Z9 61
U1 0
U2 5
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PY 2014
VL 2014
AR 131024
DI 10.1155/2014/131024
PG 7
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA AN7MO
UT WOS:000340784900001
PM 25197428
OA hybrid, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Mendoza-Núñez, VM
   Arista-Ugalde, TL
   Rosado-Pérez, J
   Ruiz-Ramos, M
   Santiago-Osorio, E
AF Manuel Mendoza-Nunez, Victor
   Laurita Arista-Ugalde, Taide
   Rosado-Perez, Juana
   Ruiz-Ramos, Mirna
   Santiago-Osorio, Edelmiro
TI Hypoglycemic and antioxidant effect of Tai chi exercise training in
   older adults with metabolic syndrome
SO CLINICAL INTERVENTIONS IN AGING
LA English
DT Article
DE Tai chi; oxidative stress; older subjects; metabolic syndrome; HbA1c
ID OXIDATIVE STRESS; ASSOCIATION; LIPOPROTEIN; MEDITATION; COGNITION;
   PROFILES; PEOPLE; PLASMA; HEALTH; MIDDLE
AB Introduction: The antioxidant and anti-inflammatory effects of Tai chi (TC) exercise training in healthy older adults has been demonstrated. However, there are no studies on this effect in older adults with metabolic syndrome (MetS).
   Purpose: The aim of this study was to determine the effect of TC exercise on oxidative stress and inflammatory markers in older adults with MetS.
   Methods: A quasi-experimental study was carried out with a sample of 110 older sedentary volunteers with clinical diagnoses of MetS: (i) a control group, n = 50, of individuals who do not participate in physical exercise, of which 37 fulfilled the entire study protocol, and (ii) an experimental group, n = 60, of subjects enrolled in a TC exercise training program (eight-form easy), 5 days a week for 6 months, in sessions of 50 min, under the supervision of a qualified instructor, of which 48 fulfilled the entire study protocol. We measured in both groups (pre-and post-intervention) the following cardiovascular parameters: resting heart rate (RHR), diastolic and systolic blood pressure (DBP and SBP), mean arterial pressure (MAP), RHR-SBP product, RHR-MAP product; glycosylated hemoglobin (HbA1c); oxidative stress markers (superoxide dismutase, total antioxidant status, thiobarbituric acid reacting substances, and oxidative stress score); and inflammation markers (TNF-alpha, IL-6, IL-8, and IL-10).
   Results: A statistically significant decrease in HbA1c concentration was observed in the TC group compared with the control group (p < 0.05). This group also showed a statistically significant increase in TAS and a decrease in the oxidative stress score (p < 0.05). We did not observe changes in the cardiovascular parameters (RHR, DBP, SBP, MAP, RHR-SBP product, and RHR-MAP product) in the TC experimental group compared to the control group.
   Conclusion: Our findings suggest that the practice of TC exercise has an antioxidative and hypoglycemic effect in the elderly with MetS.
C1 [Manuel Mendoza-Nunez, Victor; Laurita Arista-Ugalde, Taide; Rosado-Perez, Juana; Ruiz-Ramos, Mirna] Univ Nacl Autonoma Mexico, FES Zaragoza, Res Unit Gerontol, Mexico City, DF, Mexico.
   [Santiago-Osorio, Edelmiro] Univ Nacl Autonoma Mexico, FES Zaragoza, Res Unit Cell Differentiat & Canc, Hematopoiesis & Leukemia Lab, Mexico City, DF, Mexico.
C3 Universidad Nacional Autonoma de Mexico; Universidad Nacional Autonoma
   de Mexico
RP Mendoza-Núñez, VM (corresponding author), Univ Nacl Autonoma Mexico, Fac Estudios Super Zaragoza, Unidad Invest Gerontol, Guelatao 66, Mexico City 09230, DF, Mexico.
EM mendovic@unam.mx
RI Mendoza-Núñez, Víctor Manuel/AFL-2465-2022
OI Santiago-Osorio, Edelmiro/0000-0002-4876-0688
FU Direccion General de Asuntos del Personal Academico, Universidad
   Nacional Autonoma de Mexico (DGAPA, UNAM) [PAPIIT IN306213-2]; Posgrado
   en Ciencias Biologicas, UNAM; Itzen Aguiniga-Sanchez for measured of
   inflammatory cytokines
FX This work was supported by Direccion General de Asuntos del Personal
   Academico, Universidad Nacional Autonoma de Mexico (DGAPA, UNAM), PAPIIT
   IN306213-2 & Posgrado en Ciencias Biologicas, UNAM. We appreciate the
   support of Itzen Aguiniga-Sanchez for measured of inflammatory
   cytokines.
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NR 50
TC 36
Z9 36
U1 2
U2 15
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
EI 1178-1998
J9 CLIN INTERV AGING
JI Clin. Interv. Aging
PY 2018
VL 13
BP 523
EP 531
DI 10.2147/CIA.S157584
PG 9
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA GB4DK
UT WOS:000429010500003
PM 29662308
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Rosenberg, B
   Moran, A
   Sinaiko, AR
AF Rosenberg, B
   Moran, A
   Sinaiko, AR
TI Insulin resistance (metabolic) syndrome in children
SO PANMINERVA MEDICA
LA English
DT Review
DE insuline resistence; cardiovascular diseases; child
ID C-REACTIVE PROTEIN; CARDIOVASCULAR RISK-FACTORS; FREE FATTY-ACIDS;
   TYPE-2 DIABETES-MELLITUS; IMPAIRED GLUCOSE-TOLERANCE; BODY-MASS INDEX;
   NUTRITION EXAMINATION SURVEY; NECROSIS-FACTOR-ALPHA; 3RD
   NATIONAL-HEALTH; BLOOD-PRESSURE
AB The insulin resistance (metabolic) syndrome (IRS), also known as syndrome X, is characterized by a clustering of factors associated with cardiovascular risk (obesity, impaired glucose metabolism, hypertension, and dyslipidemia). As reported from the third National Health and Nutrition Examination survey, the IRS is present in approximately 24% of adults in the United States and is strongly associated with coronary heart disease, stroke, type 2 diabetes, and all-cause mortality. Of equal importance, it is now clear that the origins of the IRS extend back into childhood (the IRS is found in approximately 4-10% of children and adolescents) and that the high prevalence of adult IRS is strongly linked to the development of cardiovascular risk during childhood and tracking of the components of the IRS into adulthood. The goal of this review is to present a summary of the currently available information on the IRS in the pre-adult age group with reference to adult studies only when necessary for clarification. The review will specifically summarize insulin resistance in childhood; the important influence of obesity and, in particular, visceral fat, on insulin resistance and the IRS; differences between ethnic groups; relations to adipocytokines, inflammatory factors and oxidative stress; relations of hypertension and lipids to insulin resistance; familial factors; endocrine complications; and potential therapeutic effects from diet and physical activity. Despite the lesser amount of basic and clinical information on childhood IRS in comparison to information available from adult studies, there can now be little doubt that the adverse associations among risk factors comprising the IIRS begin in childhood. The challenge is to Identify etiologic relations and develop intervention strategies designed to reduce the increasing prevalence of type 2 diabetes and cardiovascular disease.
C1 Univ Minnesota, Sch Med, Dept Pediat, Minneapolis, MN 55455 USA.
C3 University of Minnesota System; University of Minnesota Twin Cities
RP Univ Minnesota, Sch Med, Dept Pediat, 420 Delaware St SE,MMC 49,1, Minneapolis, MN 55455 USA.
EM sinai001@umn.edu
FU NCRR NIH HHS [M01RR00400] Funding Source: Medline; NHLBI NIH HHS
   [HL52851] Funding Source: Medline; NIDDK NIH HHS [T32-DK065519] Funding
   Source: Medline
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NR 158
TC 16
Z9 19
U1 1
U2 21
PU EDIZIONI MINERVA MEDICA
PI TURIN
PA CORSO BRAMANTE 83-85 INT JOURNALS DEPT., 10126 TURIN, ITALY
SN 0031-0808
EI 1827-1898
J9 PANMINERVA MED
JI Panminerva Medica
PD DEC
PY 2005
VL 47
IS 4
BP 229
EP 244
PG 16
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 027LQ
UT WOS:000236417500004
PM 16489322
DA 2025-06-11
ER

PT J
AU Reguero, M
   de Cedrón, MG
   Sierra-Ramírez, A
   Fernández-Marcos, PJ
   Reglero, G
   Quintela, JC
   de Molina, AR
AF Reguero, Marina
   Gomez de Cedron, Marta
   Sierra-Ramirez, Aranzazu
   Jose Fernandez-Marcos, Pablo
   Reglero, Guillermo
   Carlos Quintela, Jose
   Ramirez de Molina, Ana
TI Pomegranate Extract Augments Energy Expenditure Counteracting the
   Metabolic Stress Associated with High-Fat-Diet-Induced Obesity
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE energy expenditure; thermogenesis; meta-inflammation; obesity;
   pomegranate extract
ID BROWN ADIPOSE-TISSUE; INSULIN-RESISTANCE; GENE-EXPRESSION; SEED OIL;
   MUSCLE; SIRT1; THERMOGENESIS; INFLAMMATION; HOMEOSTASIS; ACTIVATION
AB Obesity is associated to a low grade of chronic inflammation leading to metabolic stress, insulin resistance, metabolic syndrome, dislipidemia, cardiovascular disease, and even cancer. A Mediterranean diet has been shown to reduce systemic inflammatory factors, insulin resistance, and metabolic syndrome. In this scenario, precision nutrition may provide complementary approaches to target the metabolic alterations associated to "unhealthy obesity". In a previous work, we described a pomegranate extract (PomE) rich in punicalagines to augment markers of browning and thermogenesis in human differentiated adipocytes and to augment the oxidative respiratory capacity in human differentiated myocytes. Herein, we have conducted a preclinical study of high-fat-diet (HFD)-induced obesity where PomE augments the systemic energy expenditure (EE) contributing to a reduction in the low grade of chronic inflammation and insulin resistance associated to obesity. At the molecular level, PomE promotes browning and thermogenesis in adipose tissue, reducing inflammatory markers and augmenting the reductive potential to control the oxidative stress associated to the HFD. PomE merits further investigation as a complementary approach to alleviate obesity, reducing the low grade of chronic inflammation and metabolic stress.
C1 [Reguero, Marina; Gomez de Cedron, Marta; Ramirez de Molina, Ana] CEI UAM CSIC, IMDEA Food Inst, Mol Oncol Grp, Madrid 28049, Spain.
   [Reguero, Marina; Carlos Quintela, Jose] NATAC BIOTECH, Elect 7, Madrid 28923, Spain.
   [Sierra-Ramirez, Aranzazu; Jose Fernandez-Marcos, Pablo] CEI UAM CSIC, IMDEA Food, Metab Syndrome Grp, Madrid 28049, Spain.
   [Reglero, Guillermo] CEI UAM CSIC, Prod & Characterizat Novel Foods Dept, Inst Food Sci Res CIAL, Madrid 28049, Spain.
C3 Consejo Superior de Investigaciones Cientificas (CSIC); IMDEA Food
   Institute; IMDEA Food Institute; Consejo Superior de Investigaciones
   Cientificas (CSIC); Consejo Superior de Investigaciones Cientificas
   (CSIC); CSIC-UAM - Instituto de Investigacion en Ciencias de la
   Alimentacion (CIAL)
RP de Cedrón, MG; de Molina, AR (corresponding author), CEI UAM CSIC, IMDEA Food Inst, Mol Oncol Grp, Madrid 28049, Spain.
EM ana.ramirez@imdea.org
RI de Molina, Ana/AAA-3848-2019; Reglero, Guillermo/K-6658-2014;
   Fernandez-Marcos, Pablo J./F-1840-2016; Gomez de Cedron,
   Marta/M-7764-2014
OI Fernandez-Marcos, Pablo J./0000-0003-3515-4125; Reglero rada,
   Guillermo/0000-0002-7730-3486; Quintela, Jose
   Carlos/0000-0001-8479-129X; Gomez de Cedron, Marta/0000-0002-0894-970X
FU Regional Government of Community of Madrid [IND2017/BIO-7826,
   P2018/BAA-4343-ALIBIRD2020-CM]; Ministerio de Ciencia e Innovacion,
   Spain [PID2019110183RB-C21]; Ramon Areces Foundation [CIVP19A5937]; EU
   Structural Funds; COST Action [CA17118]; Synergistic Projects Community
   of Madrid [NUTRISION-CM/Y2020/BIO-6350]; REACT EU Program (Comunidad de
   Madrid); European Regional Development Fund; ERDF; European
   Union-FACINGLCOVID-CM project
FX This research was funded by the Regional Government of Community of
   Madrid IND2017/BIO-7826; P2018/BAA-4343-ALIBIRD2020-CM), Ministerio de
   Ciencia e Innovacion, Spain (PID2019110183RB-C21); Ramon Areces
   Foundation (CIVP19A5937); EU Structural Funds and COST Action (CA17118);
   Synergistic Projects Community of Madrid (NUTRISION-CM/Y2020/BIO-6350);
   and REACT EU Program (Comunidad de Madrid and The European Regional
   Development Fund. ERDF. European Union-FACINGLCOVID-CM project).
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NR 55
TC 5
Z9 5
U1 2
U2 14
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD SEP
PY 2022
VL 23
IS 18
AR 10460
DI 10.3390/ijms231810460
PG 17
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 4Q9AJ
UT WOS:000856367100001
PM 36142372
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Faits, T
   Walker, ME
   Rodriguez-Morato, J
   Meng, HC
   Gervis, JE
   Galluccio, JM
   Lichtenstein, AH
   Johnson, WE
   Matthan, NR
AF Faits, Tyler
   Walker, Maura E.
   Rodriguez-Morato, Jose
   Meng, Huicui
   Gervis, Julie E.
   Galluccio, Jean M.
   Lichtenstein, Alice H.
   Johnson, W. Evan
   Matthan, Nirupa R.
TI Exploring changes in the human gut microbiota and microbial-derived
   metabolites in response to diets enriched in simple, refined, or
   unrefined carbohydrate-containing foods: a post hoc analysis of a
   randomized clinical trial
SO AMERICAN JOURNAL OF CLINICAL NUTRITION
LA English
DT Article
DE carbohydrate quality; microbiome; metatranscriptomics; cardiometabolic
   risk factors; bile acids; randomized clinical trial
ID WHOLE-GRAIN; BILE-ACIDS; CONSUMPTION; HEALTHY; MORTALITY; CANCER; FIBER;
   RISK; METAANALYSIS; DISEASE
AB Background: Dietary carbohydrate type may influence cardiometabolic risk through alterations in the gut microbiome and microbial-derived metabolites, but evidence is limited.
   Objectives: We explored the relative effects of an isocaloric exchange of dietary simple, refined, and unrefined carbohydrate on gut microbiota composition/function, and selected microbial metabolite concentrations.
   Methods: Participants [n = 11; age: 65 +/- 8 y; BMI (in kg/m(2)): 29.8 +/- 3.2] were provided with each of 3 diets for 4.5 wk with 2-wk washout, according to a randomized, crossover design. Diets [60% of energy (%E) carbohydrate, 15%E protein, and 25%E fat] differed in type of carbohydrate. Fecal microbial composition, metatranscriptomics, and microbial-derived SCFA and secondary bile acid (SBA) concentrations were assessed at the end of each phase and associated with cardiometabolic risk factors (CMRFs).
   Results: Roseburia abundance was higher (11% compared with 5%) and fecal SBA concentrations were lower (lithocolic acid -50% and deoxycholic acid -64%) after consumption of the unrefined carbohydrate diet relative to the simple carbohydrate diet [false discovery rate (FDR): all P < 0.05), whereas Anaerostipes abundance was higher (0.35% compared with 0.12%; FDR: P = 0.04) after the simple carbohydrate diet relative to the refined carbohydrate diet. Metatranscriptomics indicated upregulation of 2 cellular stress genes (FDR: P < 0.1) after the unrefined carbohydrate diet compared with the simple carbohydrate or refined carbohydrate diets. The microbial expression of 3 cellular/oxidative stress and immune response genes was higher (FDR: P < 0.1) after the simple carbohydrate diet relative to the refined carbohydrate diet. No significant diet effect was observed in fecal SCFA concentrations. Independent of diet. we observed 16 associations (all FDR: P < 0.1) of taxon abundance (15 phylum and 1 genera) with serum inflammatory markers and also with fecal SCFA and SBA concentrations.
   Conclusions: Consuming an unrefined carbohydrate-rich diet had a modest effect on the gut microbiome and SBAs, resulting in favorable associations with selected CMRFs. Simple carbohydrate- and refined carbohydrate-rich diets have distinctive effects on the gut microbiome, suggesting differential mechanisms mediate their effects on cardiometabolic health.
C1 [Faits, Tyler; Walker, Maura E.; Johnson, W. Evan] Boston Univ, Sch Med, Dept Med, Div Computat Biomed, Boston, MA 02118 USA.
   [Walker, Maura E.] Boston Univ, Dept Med, Sect Prevent Med & Epidemiol, Sch Med, Boston, MA 02118 USA.
   [Rodriguez-Morato, Jose] Pompeu Fabra Univ, Barcelona, Spain.
   [Rodriguez-Morato, Jose; Meng, Huicui; Gervis, Julie E.; Galluccio, Jean M.; Lichtenstein, Alice H.; Matthan, Nirupa R.] Tufts Univ, Cardiovasc Nutr, Jean Mayer USDA Human Nutr Res Ctr Aging, Boston, MA 02111 USA.
   [Meng, Huicui] Sun Yat Sen Univ, Sch Publ Hlth Shenzhen, Guangzhou, Guangdong, Peoples R China.
C3 Boston University; Boston University; Pompeu Fabra University; Tufts
   University; United States Department of Agriculture (USDA); Sun Yat Sen
   University
RP Matthan, NR (corresponding author), Tufts Univ, Cardiovasc Nutr, Jean Mayer USDA Human Nutr Res Ctr Aging, Boston, MA 02111 USA.
EM nirupa.matthan@tufts.edu
RI Gervis, Julie/HNT-0471-2023; Meng, Huicui/E-9497-2017; Rodríguez Morató,
   Jose/T-9331-2018; Walker, Maura/IQS-6112-2023; Rodriguez-Morato,
   Jose/N-9063-2014
OI Walker, Maura/0000-0001-9935-4113; Rodriguez-Morato,
   Jose/0000-0002-8133-9983; Lichtenstein, Alice H/0000-0002-1053-9478;
   Gervis, Julie/0000-0003-0125-9930; Faits, Tyler/0000-0002-7524-6166
FU Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts
   University; Boston Obesity Research Center; US Department of Agriculture
   [58-1950-4-401]; National Heart, Lung, and Blood Institute/NIH [NHLBI
   T32-HL069772]; National Heart, Lung, and Blood Institute/NIH
   Multidisciplinary Training Program in Cardiovascular Epidemiology
   [5T32-HL125232]
FX Pilot funds were provided by the Jean Mayer USDA Human Nutrition
   Research Center on Aging at Tufts University and Boston Obesity Research
   Center to AHL; the US Department of Agriculture (agreement
   58-1950-4-401) to AHL and NRM; and grant NHLBI T32-HL069772 from the
   National Heart, Lung, and Blood Institute/NIH to AHL. MEW is supported
   by grant 5T32-HL125232 from the National Heart, Lung, and Blood
   Institute/NIH Multidisciplinary Training Program in Cardiovascular
   Epidemiology. Any opinions, findings, conclusions, or recommendations
   expressed in this publication are those of authors and do not
   necessarily reflect the view of the US Department of Agriculture or the
   National Institutes of Health.
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NR 50
TC 17
Z9 18
U1 0
U2 19
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0002-9165
EI 1938-3207
J9 AM J CLIN NUTR
JI Am. J. Clin. Nutr.
PD DEC
PY 2020
VL 112
IS 6
BP 1631
EP 1641
DI 10.1093/ajcn/nqaa254
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA PD8YM
UT WOS:000597963400027
PM 32936872
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Wu, XG
   Zhang, T
   Park, S
AF Wu, Xuangao
   Zhang, Ting
   Park, Sunmin
TI Dietary quality, perceived health, and psychological status as key risk
   factors for newly developed metabolic dysfunction-associated steatotic
   liver disease in a longitudinal study
SO NUTRITION
LA English
DT Article
DE MASLD; Self-rated health; Psychological well-being index; Metabolic
   syndrome; Healthy eating index
ID BIOMARKERS; SEVERITY; VARIANT; MAFLD; MASLD
AB Objectives: This study investigated biomarkers in individuals with newly developed metabolic dysfunction-associated steatotic liver disease (ND-MASLD) and examined the interplay between genetic predisposition and environmental factors using a machine learning approach in a large longitudinal study. Methods: Participants were classified into four groups based on metabolic dysfunction-associated steatotic liver disease (MASLD) status between the first and second measurements with an approximate 5-y gap. A model was developed to identify early-stage biomarkers of ND-MASLD (n = 1603). Nutrient intake, dietary patterns, genetic variants, and psychosocial factors were compared among the no MASLD (n = 60081), recovered MASLD (n = 3181), persistent MASLD (n = 670), and ND-MASLD (n = 1603) groups. Their association with ND-MASLD was also predicted using a machine learning approach. Results: The model incorporating ND-MASLD status, age, sex, dietary inflammatory index, and metabolic syndrome (MetS), especially low high-density lipoprotein cholesterol and hypertriglyceridemia, at the second measurement demonstrated an optimal fit. High carbohydrate intake with a high glycemic index was associated with elevated ND-MADSLD risk. Fatty liver index was lower in persistent MASLD followed by NDMASLD, recovered MASLD, and no MASLD. Participants in the ND-MASLD group had lower vitamin D and total isoflavonoid intake and a lower modified healthy eating index, indicating unhealthy diets. The XGBoost and deep neural network models identified age, sex, MetS components, dietary antioxidants, self-rated health, psychological well-being indexes, and serum liver enzyme levels at the second measurement as significant predictors of ND-MASLD. However, polygenic risk scores were not included. Conclusions: Early-stage biomarkers of ND-MASLD were closely linked to MetS incidence. Dietary quality, perceived health status, and psychological stress emerged as potential targets for MASLD prevention strategies, with lifestyle modifications potentially overriding genetic predispositions. The results indicate that preventive strategies about lifestyle modification should be developed for MASLD. (c) 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.
C1 [Wu, Xuangao; Zhang, Ting; Park, Sunmin] Hoseo Univ, Korea Dept Bioconvergence, Asan, South Korea.
   [Park, Sunmin] Hoseo Univ, Obes Diabet Res Ctr, Dept Food & Nutr, Asan, South Korea.
C3 Hoseo University; Hoseo University
RP Park, S (corresponding author), Hoseo Univ, Korea Dept Bioconvergence, Asan, South Korea.; Park, S (corresponding author), Hoseo Univ, Obes Diabet Res Ctr, Dept Food & Nutr, Asan, South Korea.
EM niyani0@naver.com; zhangting92925@gmail.com; smpark@hoseo.edu
RI zhang, ting/GXV-1734-2022
OI Park, Sunmin/0000-0002-6092-8340
FU National Research Foundation of Korea - Ministry of Science and ICT
   [RS-2023-00208567]; Korea Food and Drug Administration
FX This study was supported by a grant from the National Research
   Foundation of Korea funded by the Ministry of Science and ICT
   (RS-2023-00208567) and the Korea Food and Drug Administration.
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NR 49
TC 0
Z9 0
U1 4
U2 4
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0899-9007
EI 1873-1244
J9 NUTRITION
JI Nutrition
PD FEB
PY 2025
VL 130
AR 112604
DI 10.1016/j.nut.2024.112604
EA NOV 2024
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA M7J9I
UT WOS:001359269500001
PM 39549647
DA 2025-06-11
ER

PT J
AU Quinn, M
   Shinkai, K
   Pasch, L
   Kuzmich, L
   Cedars, M
   Huddleston, H
AF Quinn, Molly
   Shinkai, Kanade
   Pasch, Lauri
   Kuzmich, Lili
   Cedars, Marcelle
   Huddleston, Heather
TI Prevalence of androgenic alopecia in patients with polycystic ovary
   syndrome and characterization of associated clinical and biochemical
   features
SO FERTILITY AND STERILITY
LA English
DT Article
DE Polycystic ovary syndrome; androgenic alopecia; clinical
   hyperandrogenism
ID INSULIN-RESISTANCE; METABOLIC SYNDROME; HAIR LOSS; WOMEN; ANXIETY;
   EXCESS; CRITERIA; HORMONE
AB Objective: To describe the prevalence of androgenic alopecia (AGA) in patients with polycystic ovary syndrome (PCOS) and to characterize associated clinical and biochemical features.
   Design: Cross-sectional study.
   Setting: Multidisciplinary PCOS clinic at a tertiary academic center.
   Patient(s): A total of 254 women with PCOS according to the Rotterdam criteria were systematically examined from 2007 to 2012 by a reproductive endocrinologist, a dermatologist, and a psychologist.
   Intervention(s): Comprehensive dermatologic exams, ultrasonic imaging, serum testing, and Beck Depression Inventory Fast Screen (BDI-FS).
   Main Outcome Measures: Presence of AGA, acne, hirsutism, biochemical hyperandrogenemia, metabolic dysfunction, and clinical depression.
   Result(s): Fifty-six of 254 patients with PCOS (22.0%) had AGA. Subjects with PCOS and AGA were more likely to have acne or hirsutism than those without AGA (96.3% vs. 70.6%). Subjects with AGA were more likely to report concern with hair loss (70.4% vs. 37.7%); however, their BDI-FS scores were no different from subjects without AGA. There were no differences between subjects with and without AGA in biochemical hyperandrogenism or metabolic parameters.
   Conclusion(s): AGA is prevalent in 22% of subjects meeting diagnostic criteria for PCOS. AGA is associated with other manifestations of clinical hyperandrogenism, but not with greater risk of biochemical hyperandrogenemia or metabolic dysfunction than with PCOS alone. (c) 2014 by American Society for Reproductive Medicine.
C1 [Quinn, Molly; Cedars, Marcelle; Huddleston, Heather] Univ Calif San Francisco, Sch Med, Dept Obstet Gynecol & Reprod Sci, San Francisco, CA 94143 USA.
   [Shinkai, Kanade] Univ Calif San Francisco, Sch Med, Dept Dermatol, San Francisco, CA 94143 USA.
   [Pasch, Lauri] Univ Calif San Francisco, Sch Med, Dept Psychiat, San Francisco, CA 94143 USA.
   [Kuzmich, Lili] Univ Calif San Francisco, Sch Med, Canc Risk Program, San Francisco, CA 94143 USA.
C3 University of California System; University of California San Francisco;
   University of California System; University of California San Francisco;
   University of California System; University of California San Francisco;
   University of California System; University of California San Francisco
RP Quinn, M (corresponding author), Univ Calif San Francisco, Sch Med, Dept Obstet Gynecol & Reprod Sci, 505 Parnassus Ave,Room 1483,Box 0132, San Francisco, CA 94143 USA.
EM quinnm@obgyn.ucsf.edu
OI Huddleston, Heather/0000-0001-5350-6951
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NR 37
TC 44
Z9 47
U1 2
U2 12
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0015-0282
EI 1556-5653
J9 FERTIL STERIL
JI Fertil. Steril.
PD APR
PY 2014
VL 101
IS 4
BP 1129
EP 1134
DI 10.1016/j.fertnstert.2014.01.003
PG 6
WC Obstetrics & Gynecology; Reproductive Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology; Reproductive Biology
GA AE2LR
UT WOS:000333805000049
PM 24534277
OA Bronze
DA 2025-06-11
ER

PT J
AU Marycz, K
   Kornicka, K
   Basinska, K
   Czyrek, A
AF Marycz, Krzysztof
   Kornicka, Katarzyna
   Basinska, Katarzyna
   Czyrek, Aleksandra
TI Equine Metabolic Syndrome Affects Viability, Senescence, and Stress
   Factors of Equine Adipose-Derived Mesenchymal Stromal Stem Cells: New
   Insight into EqASCs Isolated from EMS Horses in the Context of Their
   Aging
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Article
ID OXIDATIVE STRESS; OBESITY; TISSUE; MITOCHONDRIA
AB Currently, equine metabolic syndrome (EMS), an endocrine disease linked to insulin resistance, affects an increasing number of horses. However, little is known about the effect of EMS on mesenchymal stem cells that reside in adipose tissue (ASC). Thus it is crucial to evaluate the viability and growth kinetics of these cells, particularly in terms of their application in regenerative medicine. In this study, we investigated the proliferative capacity, morphological features, and accumulation of oxidative stress factors in mesenchymal stem cells isolated from healthy animals (ASC(N)) and horses suffering from EMS (ASC(EMS)). ASC(EMS) displayed senescent phenotype associated with beta-galactosidase accumulation, enlarged cell bodies and nuclei, increased apoptosis, and reduced heterochromatin architecture. Moreover, we observed increased amounts of nitric oxide (NO) and reactive oxygen species (ROS) in these cells, accompanied by reduced superoxide dismutase (SOD) activity. We also found in ASC(EMS) an elevated number of impaired mitochondria, characterized by membrane raptures, disarrayed cristae, and vacuole formation. Our results suggest that the toxic compounds, accumulating in the mitochondria under oxidative stress, lead to alternations in their morphology and may be partially responsible for the senescent phenotype and decreased proliferation potential of ASC(EMS).
C1 [Marycz, Krzysztof; Kornicka, Katarzyna; Basinska, Katarzyna] Wroclaw Univ Environm & Life Sci, Electron Microscopy Lab, Kozuchowska 5b, PL-51631 Wroclaw, Poland.
   [Marycz, Krzysztof; Czyrek, Aleksandra] Wroclaw Res Ctr EIT, PL-54066 Wroclaw, Poland.
C3 Wroclaw University of Environmental & Life Sciences
RP Marycz, K (corresponding author), Wroclaw Univ Environm & Life Sci, Electron Microscopy Lab, Kozuchowska 5b, PL-51631 Wroclaw, Poland.; Marycz, K (corresponding author), Wroclaw Res Ctr EIT, PL-54066 Wroclaw, Poland.
EM krzysztofmarycz@interia.pl
RI Marycz, Krzysztof/A-2249-2017; Czyrek, Aleksandra/JHT-5347-2023
OI Czyrek, Aleksandra/0000-0002-8518-7075
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NR 32
TC 67
Z9 69
U1 0
U2 2
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PY 2016
VL 2016
AR 4710326
DI 10.1155/2016/4710326
PG 17
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA DE6YY
UT WOS:000370782100001
PM 26682006
OA Green Published, hybrid, Green Submitted
DA 2025-06-11
ER

PT J
AU Ahn, S
   Esquivel, JH
   Davis, EM
   Logan, JG
   Chung, ML
AF Ahn, Soojung
   Esquivel, Jill Howie
   Davis, Eric M.
   Logan, Jeongok G.
   Chung, Misook Lee
TI Cardiovascular Disease Incidence and Risk in Family Caregivers of Adults
   With Chronic Conditions A Systematic Review
SO JOURNAL OF CARDIOVASCULAR NURSING
LA English
DT Review
DE caregiver burden; cardiovascular diseases; risk factors; biomarkers;
   systematic review
ID CORONARY-HEART-DISEASE; ALL-CAUSE MORTALITY; C-REACTIVE PROTEIN;
   BLOOD-PRESSURE; DEPRESSIVE SYMPTOMS; CHRONIC STRESS; LONGITUDINAL
   ANALYSIS; PSYCHOLOGICAL STRESS; LEISURE SATISFACTION; ACTIVITY
   RESTRICTION
AB Background Family caregivers experience psychological distress or physical strain that may lead to an increased risk of cardiovascular disease (CVD) morbidity and mortality. Objective This systematic review aimed to describe the current evidence and gaps in the literature on measures used to assess CVD outcomes in family caregivers, the association of caregiving with CVD incidence/risk outcomes, and associated factors in family caregivers of patients with chronic disease. Methods Medline, PubMed, CINAHL, Web of Science, and Google Scholar were searched for English-language, peer-reviewed studies published from 2008 to 2020 that examined CVD incidence and risk among family caregivers of adults with chronic conditions. Results Forty-one studies were included in this review. The measures used to assess CVD risk were categorized into biochemical, subclinical markers, components of metabolic syndrome, and global risk scores. Compared with noncaregivers, caregivers were more likely to have higher CVD incidence rates and objectively measured risk. Cardiovascular disease risks were also increased by their caregiving experience, including hours/duration of caregiving, caregivers' poor sleep status, psychological symptoms, poor engagement in physical/leisure activities, and care recipient's disease severity. Conclusions Although there were limited longitudinal studies in caregivers of patients with diverse health conditions, we found evidence that caregivers are at high risk of CVD. Further research for various caregiver groups using robust methods of measuring CVD risk is needed. Caregiver factors should be considered in developing interventions aimed at reducing CVD risk for caregivers.
C1 [Ahn, Soojung; Esquivel, Jill Howie; Logan, Jeongok G.] Univ Virginia, Sch Nursing, 202 Jeanette Lancaster Way, Charlottesville, VA 22903 USA.
   [Davis, Eric M.] Univ Virginia, Sch Med, Charlottesville, VA 22908 USA.
   [Chung, Misook Lee] Univ Kentucky, Coll Nursing, Lexington, KY USA.
   [Chung, Misook Lee] Yonsei Univ, Coll Nursing, Seoul, South Korea.
C3 University of Virginia; University of Virginia; University of Kentucky;
   Yonsei University; Yonsei University Health System
RP Ahn, S (corresponding author), Univ Virginia, Sch Nursing, 202 Jeanette Lancaster Way, Charlottesville, VA 22903 USA.
EM sa4ve@virginia.edu; jhe9f@virginia.edu; EMD9B@hscmail.mcc.virginia.edu;
   jl3zj@virginia.edu; misook.chung@uky.edu
RI Esquivel, Jill/ITT-1965-2023; Chung, Misook/AAG-2499-2021
OI Ahn, Soojung/0000-0002-4234-3576
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NR 74
TC 22
Z9 23
U1 2
U2 9
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0889-4655
EI 1550-5049
J9 J CARDIOVASC NURS
JI J. Cardiovasc. Nurs.
PD MAY-JUN
PY 2022
VL 37
IS 3
BP E47
EP E60
DI 10.1097/JCN.0000000000000816
PG 14
WC Cardiac & Cardiovascular Systems; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Cardiovascular System & Cardiology; Nursing
GA 0L0KN
UT WOS:000781173700005
PM 33938535
DA 2025-06-11
ER

PT J
AU Hasani, M
   Mansour, A
   Asayesh, H
   Djalalinia, S
   Gorabi, AM
   Ochi, F
   Qorbani, M
AF Hasani, Motahareh
   Mansour, Asieh
   Asayesh, Hamid
   Djalalinia, Shirin
   Gorabi, Armita Mahdavi
   Ochi, Fatemeh
   Qorbani, Mostafa
TI Effect of glutamine supplementation on cardiometabolic risk factors and
   inflammatory markers: a systematic review and meta-analysis
SO BMC CARDIOVASCULAR DISORDERS
LA English
DT Review
DE Glutamine; Cardiometabolic risk factors; Systematic review;
   Meta-analysis
ID GLUCAGON-LIKE PEPTIDE-1; HEAT-SHOCK-PROTEIN; ALANYL-GLUTAMINE; STRESS
   HYPERGLYCEMIA; INSULIN SENSITIVITY; GLUCOSE-METABOLISM; ENTERAL
   NUTRITION; HEAT-SHOCK-PROTEIN-70; WEIGHT; OBESE
AB Background Evidence exists that glutamine plays multiple roles in glucose metabolism, insulin sensitivity, and anti-inflammatory effects. This systematic review and meta-analysis of controlled trials aimed to assess the effect of glutamine supplementation on cardio-metabolic risk factors and inflammatory markers. Methods The processes of systematic reviews and meta-analyses were performed according to the PRISMA checklist. PubMed, Web of Sciences, Cochrane library, and Scopus databases were search for relevant studies without time or language restrictions up to December 30, 2020. All randomized clinical trials which assessed the effect of glutamine supplementation on "glycemic indices", "level of triglyceride, "and "inflammatory markers" were included in the study. The effect of glutamine supplementation on cardio-metabolic risk factors and inflammatory markers was assessed using a standardized mean difference (SMD) and 95% confidence interval (CI). Heterogeneity between among studies was assessed using Cochran Q-statistic and I-square. Random/fixed-effects meta-analysis method was used to estimate the pooled SMD. The risk of bias for the included trials was evaluated using the Cochrane quality assessment tool. Results In total, 12 studies that assessed the effect of glutamine supplementation on cardio-metabolic risk factors were included in the study. Meta-analysis showed that glutamine supplementation significantly decreased significantly serum levels of FPG [SMD: - 0.73, 95% CI - 1.35, - 0.11, I-2: 84.1%] and CRP [SMD: - 0.58, 95% CI - 0.1, - 0.17, I-2: 0%]. The effect of glutamine supplementation on other cardiometabolic risk factors was not statistically significant (P > 0.05). Conclusion Our findings showed that glutamine supplementation might have a positive effect on FPG and CRP; both of which are crucial as cardio-metabolic risk factors. However, supplementation had no significant effect on other cardio-metabolic risk factors.
C1 [Hasani, Motahareh] Iran Univ Med Sci, Sch Publ Hlth, Dept Nutr, Tehran, Iran.
   [Mansour, Asieh] Shahid Beheshti Univ Med Sci, Natl Nutr & Food Technol Res Inst, Fac Nutr & Food Technol, Dept Clin Nutr & Dietet, Tehran, Iran.
   [Mansour, Asieh] Univ Tehran Med Sci, Endocrinol & Metab Clin Sci Inst, Endocrinol & Metab Res Ctr, Tehran, Iran.
   [Asayesh, Hamid] Qom Univ Med Sci, Dept Med Emergencies, Qom, Iran.
   [Djalalinia, Shirin] Univ Tehran Med Sci, Noncommunicable Dis Res Ctr, Endocrinol & Metab Populat Sci Inst, Tehran, Iran.
   [Djalalinia, Shirin] Minist Hlth & Med Educ, Dev Res & Technol Ctr, Deputy Res & Technol, Tehran, Iran.
   [Gorabi, Armita Mahdavi] Alborz Univ Med Sci, Social Determinants Hlth Res Ctr, Karaj, Iran.
   [Qorbani, Mostafa] Alborz Univ Med Sci, Noncommunicable Dis Res Ctr, Karaj, Iran.
   [Ochi, Fatemeh] Alborz Univ Med Sci, Students Res Comm, Karaj, Iran.
   [Qorbani, Mostafa] Univ Tehran Med Sci, Chron Dis Res Ctr, Endocrinol & Metab Populat Sci Inst, Tehran, Iran.
C3 Iran University of Medical Sciences; Shahid Beheshti University Medical
   Sciences; Tehran University of Medical Sciences; Tehran University of
   Medical Sciences; Ministry of Health & Medical Education (MOHME); Alborz
   University of Medical Sciences; Alborz University of Medical Sciences;
   Alborz University of Medical Sciences; Tehran University of Medical
   Sciences
RP Asayesh, H (corresponding author), Qom Univ Med Sci, Dept Med Emergencies, Qom, Iran.; Qorbani, M (corresponding author), Alborz Univ Med Sci, Noncommunicable Dis Res Ctr, Karaj, Iran.; Qorbani, M (corresponding author), Univ Tehran Med Sci, Chron Dis Res Ctr, Endocrinol & Metab Populat Sci Inst, Tehran, Iran.
EM hasayesh@gmail.com; mqorbani1379@gmail.com
RI Demissie, Dereje/AAN-3556-2021; Qorbani, Mostafa/M-8171-2017; Hasani,
   Motahareh/AAY-8608-2020
OI hasani, motahareh/0000-0002-9002-1192
FU National Institute for Medical Research Development (NIMAD) [971234]
FX This study was supported by National Institute for Medical Research
   Development (NIMAD), Grant No. 971234.
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NR 53
TC 15
Z9 15
U1 1
U2 9
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1471-2261
J9 BMC CARDIOVASC DISOR
JI BMC Cardiovasc. Disord.
PD APR 17
PY 2021
VL 21
IS 1
AR 190
DI 10.1186/s12872-021-01986-8
PG 21
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA RP5JG
UT WOS:000641764300002
PM 33865313
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Maes, M
   Jirakran, K
   Vasupanrajit, A
   Zhou, B
   Tunvirachaisakul, C
   Stoyanov, DS
   Almulla, AF
AF Maes, Michael
   Jirakran, Ketsupar
   Vasupanrajit, Asara
   Zhou, Bo
   Tunvirachaisakul, Chavit
   Stoyanov, Drozdstoj ST.
   Almulla, Abbas F.
TI Are abnormalities in lipid metabolism, together with adverse childhood
   experiences, the silent causes of immune-linked neurotoxicity in major
   depression?
SO NEUROENDOCRINOLOGY LETTERS
LA English
DT Article
DE major depression; neuro-immune; inflammation; lipids; LCAT; biomarkers
ID BLOOD-BRAIN-BARRIER; SUICIDAL BEHAVIORS; RATING-SCALE; CHOLESTEROL;
   INFLAMMATION; ADOLESCENTS; RESISTANCE; SEVERITY; CYTOKINE; DISORDER
AB BACKGROUND: Severe or recurring major depression is associated with increased adverse childhood experiences (ACEs), heightened atherogenicity, and immune- linked neurotoxicity (INT). Nevertheless, the interconnections among these variables in outpatient major depression (OMDD) have yet to be determined. We aim to determine the correlations among INT, atherogenicity, and ACEs in OMDD patients compared to normal controls. METHODS: This study includes 66 OMDD patients (of whom 33 had metabolic syndrome, MetS) and 67 controls (31 of whom had MetS) and used Multiplex Immunoassay to assess serum levels of forty eight cytokines/chemokines/growth factors .RESULTS: The free cholesterol/reverse cholesterol transport ratio, apolipoprotein (Apo) B and E, and a comprehensive atherogenicity index were significantly associated with increased INT in subjects without MetS. ACEs were substantially correlated with INT in individuals with MetS. INT (only in MetS) and atherogenicity indices (only in people without MetS) were significantly associated with the clinical phenome features of OMDD, including the recurrence of illness (ROI, including lifetime suicidal behaviors), the lifetime phenome (neuroticism, lifetime anxiety disorders and dysthymia), and the current phenome (including current suicidal behaviors). A significant proportion of the variability (58.3%) in the lifetime + current phenome could be accounted for by INT, interactions between INT and atherogenicity (labeled "atherommune index"), ApoE, three ACE subtypes (all positively correlated), and age (inversely correlated). A common latent construct could be extracted from ROI, lifetime phenome, current phenome, INT, and atherommune index. 36.1% of this factor's variance was accounted by three ACE subtypes. CONCLUSION: We have developed a novel OMDD model, namely a pathway phenotype, labeled the "atherommune-phenome," which demonstrates that the interplay between INT and atherogenicity is essential to OMDD.
C1 [Maes, Michael; Zhou, Bo; Almulla, Abbas F.] Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Sichuan Prov Ctr Mental Hlth, Sch Med, Chengdu 610072, Peoples R China.
   [Maes, Michael; Zhou, Bo; Almulla, Abbas F.] Chinese Acad Med Sci, Key Lab Psychosomat Med, Chengdu 610072, Peoples R China.
   [Maes, Michael; Jirakran, Ketsupar; Vasupanrajit, Asara; Tunvirachaisakul, Chavit; Almulla, Abbas F.] Chulalongkorn Univ, Fac Med, Dept Psychiat, Bangkok, Thailand.
   [Maes, Michael; Jirakran, Ketsupar; Vasupanrajit, Asara; Tunvirachaisakul, Chavit] Chulalongkorn Univ, Fac Med, Dept Psychiat, Ph D Program Mental Hlth, Bangkok, Thailand.
   [Maes, Michael; Tunvirachaisakul, Chavit] Chulalongkorn Univ, Fac Med, Cognit Impairment & Dementia Res Unit, Bangkok, Thailand.
   [Maes, Michael] Chulalongkorn Univ, Fac Med, Cognit Fitness & Biopsychol Technol Res Unit, Bangkok, Thailand.
   [Maes, Michael; Stoyanov, Drozdstoj ST.] Med Univ Plovdiv, Dept Psychiat, Plovdiv, Bulgaria.
   [Maes, Michael; Stoyanov, Drozdstoj ST.] Med Univ Plovdiv, Res Inst, Plovdiv, Bulgaria.
   [Maes, Michael] Kyung Hee Univ, 26 Kyungheedae Ro, Seoul 02447, South Korea.
   [Maes, Michael; Stoyanov, Drozdstoj ST.] European Union ? NextGenerationEU, Creat network Res Higher Sch, Res & Innovat Program Dev MU PLOVDIV SRIPD MUP, Natl Plan Recovery & Sustainabil, Brussels, MA 02141 USA.
   [Jirakran, Ketsupar] UMHAT Kaspela Plovdiv, Bangkok, Bulgaria.
   [Almulla, Abbas F.] Islamic Univ, Coll Med Technol, Med Lab Technol Dept, Najaf, Iraq.
C3 University of Electronic Science & Technology of China; Sichuan
   Provincial People's Hospital; Chinese Academy of Medical Sciences -
   Peking Union Medical College; Chulalongkorn University; Chulalongkorn
   University; Chulalongkorn University; Chulalongkorn University; Medical
   University Plovdiv; Medical University Plovdiv; Kyung Hee University;
   Medical University Plovdiv; Islamic University College
RP Almulla, AF (corresponding author), Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Sichuan Prov Ctr Mental Hlth, Sch Med, Chengdu 610072, Peoples R China.
EM abbass.chem.almulla1991@gmail.com
RI Maes, Michael/B-8546-2011; Vasupanrajit, Asara/ABG-5437-2021; Almulla,
   Abbas F./GPW-6234-2022
FU Comenius University in Bratislava [UK/253/2022, VEGA 1/0022/23];
   Ratchadapiseksompotch Fund, Graduate Affairs, Faculty of Medicine,
   Chulalongkorn University [GA64/21]; CU Graduate School Thesis Grant;
   Chulalongkorn University Graduate Scholarship; Thailand Science
   research, and Innovation Fund Chulalongkorn University [HEA663000016];
   Sompoch Endowment Fund (Faculty of Medicine) MDCU [RA66/016, numero;
   BG-RRP-2.004-0007-Scy;01]
FX This study was as supported by a grant of Comenius University in
   Bratislava (UK/253/2022) and by a research grant of Scientific Grant
   Agency (VEGA 1/0022/23) .
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TC 0
Z9 0
U1 0
U2 0
PU MAGHIRA & MAAS PUBLICATIONS
PI MUNSBACH
PA MAGHIRA & MAAS S A R L, 6C, RUE GABRIEL LIPPMANN, L-5365 MUNSBACH,
   LUXEMBOURG
SN 0172-780X
EI 2354-4716
J9 NEUROENDOCRINOL LETT
JI Neuroendocrinol. Lett.
PY 2024
VL 45
IS 6
PG 72
WC Endocrinology & Metabolism; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology
GA X0G3G
UT WOS:001422237800005
DA 2025-06-11
ER

PT J
AU Rosendale, N
   Albert, MA
AF Rosendale, Nicole
   Albert, Michelle A.
TI The Intersection of Sexual Orientation, Gender Identity, and
   Race/Ethnicity on Cardiovascular Health: a Review of the Literature and
   Needed Research
SO CURRENT CARDIOVASCULAR RISK REPORTS
LA English
DT Review
DE LGBT; Sexual and gender minority health; Racial; ethnic disparities;
   Intersectionality; Cardiovascular health disparities; Health equity
ID CARDIOMETABOLIC RISK; DIURNAL CORTISOL; BLOOD-PRESSURE; MENTAL-HEALTH;
   UNITED-STATES; US ADULTS; TRANSGENDER; STRESS; INDIVIDUALS; DISEASE
AB Purpose of Review This review discusses the current literature about the cardiovascular health of sexual and gender minority (SGM) individuals with a particular focus on the intersection between SGM identity and race/ethnicity, describes potential contributions to observed differences, and suggests interventions to begin to improve cardiovascular health equity in this community. Recent Findings Research on cardiovascular health in SGM individuals predominantly focuses on individual cardiovascular health risk factors and has conflicting results. The studies assessing cardiovascular health outcomes in SGM people show mixed results and are limited by reliance on self-reported cardiovascular diagnoses. Research examining the intersectional influences of race/ethnicity and SGM identity on cardiovascular health is even more sparse, particularly in gender minority cardiovascular health. While some studies suggest disparate prevalence of cardiovascular risk factors like tobacco use, hypertension, and obesity in SGM people of color, the small number of these studies limits the interpretation of this body of research. The etiology for differential cardiovascular health is likely multifactorial, with contribution of inequitable access to appropriate healthcare, lack of SGM culturally competent clinicians, and discrimination within the healthcare system. Another potential component is the link between minority stress and physical health, a growing area of research in SGM health. Systematic research about the intersectional influences of race, ethnicity, sexual orientation, and gender identity on cardiovascular health is urgently needed. A first step could be to enable electronic health record capture of demographic characteristics that include sexual orientation and gender identity in addition to race/ethnicity. This intervention, combined with training for healthcare providers and staff, would be a powerful step toward providing more equitable cardiovascular care for this underserved community.
C1 [Rosendale, Nicole] Univ Calif San Francisco, Dept Neurol, Med Ctr, San Francisco, CA 94143 USA.
   [Rosendale, Nicole] Univ Calif San Francisco, Weill Inst Neurosci, San Francisco, CA 94143 USA.
   [Albert, Michelle A.] Ctr Study Advers & Cardiovasc Dis NURTURE Ctr, San Francisco, CA USA.
   [Albert, Michelle A.] Univ Calif San Francisco, Dept Cardiol, Med Ctr, San Francisco, CA USA.
C3 University of California System; University of California San Francisco;
   University of California System; University of California San Francisco;
   University of California System; University of California San Francisco
RP Rosendale, N (corresponding author), Univ Calif San Francisco, Dept Neurol, Med Ctr, San Francisco, CA 94143 USA.; Rosendale, N (corresponding author), Univ Calif San Francisco, Weill Inst Neurosci, San Francisco, CA 94143 USA.
EM Nicole.Rosendale@ucsf.edu
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NR 50
TC 8
Z9 9
U1 0
U2 6
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1932-9520
EI 1932-9563
J9 CURR CARDIOVASC RISK
JI Curr. Cardiovascu. Risk Rep.
PD AUG 19
PY 2020
VL 14
IS 10
AR 17
DI 10.1007/s12170-020-00651-7
PG 7
WC Cardiac & Cardiovascular Systems
WE Emerging Sources Citation Index (ESCI)
SC Cardiovascular System & Cardiology
GA ND7TI
UT WOS:000562105500001
DA 2025-06-11
ER

PT J
AU Choi, HS
   Lee, JE
AF Choi, Hye-Seung
   Lee, Jong-Eun
TI Factors Affecting Depression in Middle-Aged and Elderly Men Living
   Alone: A Cross-Sectional Path Analysis Model
SO AMERICAN JOURNAL OF MENS HEALTH
LA English
DT Article
DE socioeconomic status; depression; living alone; middle-aged and elderly
   men; reserve capacity model
ID RESERVE CAPACITY MODEL; SOCIOECONOMIC-STATUS; PSYCHOLOGICAL-FACTORS;
   PSYCHOSOCIAL FACTORS; METABOLIC SYNDROME; HEALTH; ASSOCIATION; RESOURCES
AB The main objectives of this cross-sectional study were to determine the relationship between socioeconomic status (SES) and depression and to estimate the mediating effects of social network satisfaction, self-esteem, and perceived health status among middle-aged and elderly men living alone, based on the reserve capacity model. Secondary data from a sample of 394 middle-aged and elderly men aged 45 years or older from the 15th Korea Welfare Panel Study (KOWEPS) were analyzed. A path analysis model was constructed to evaluate the relationship among SES, social network satisfaction, self-esteem, perceived health status, and depression. The path analysis exhibited significant direct effects of social network satisfaction, self-esteem, and perceived health status on depression and significant indirect effects of SES on depression. There was no direct effect of SES on depression. Social network satisfaction and self-esteem had significant mediating effects of SES on depression. Among middle-aged and elderly men, intrapersonal reserves, which are psychosocial factors including social network satisfaction, self-esteem, and perceived health status, showed more association with depression than tangible reserves such as SES. This suggests that interventions promoting self-esteem and perceived health status could prevent depression.
C1 [Choi, Hye-Seung; Lee, Jong-Eun] Catholic Univ Korea, Coll Nursing, 222 Banpo Daero, Seoul 06591, South Korea.
C3 Catholic University of Korea
RP Lee, JE (corresponding author), Catholic Univ Korea, Coll Nursing, 222 Banpo Daero, Seoul 06591, South Korea.
EM jlee@catholic.ac.kr
OI LEE, JONG-EUN/0000-0002-5989-5086; Choi, Hye Seung/0000-0001-5694-6821
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NR 58
TC 14
Z9 13
U1 1
U2 20
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1557-9883
EI 1557-9891
J9 AM J MENS HEALTH
JI Am. J. Mens Health
PD JAN
PY 2022
VL 16
IS 1
AR 15579883221078134
DI 10.1177/15579883221078134
PG 11
WC Public, Environmental & Occupational Health
WE Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA ZO5CN
UT WOS:000765742600001
PM 35184578
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Latorre-Millan, M
   Rupérez, AI
   González-Gil, EM
   Santaliestra-Pasías, A
   Vázquez-Cobela, R
   Gil-Campos, M
   Aguilera, CM
   Gil, A
   Moreno, LA
   Leis, R
   Bueno, G
AF Latorre-Millan, Miriam
   Ruperez, Azahara I.
   Gonzalez-Gil, Esther M.
   Santaliestra-Pasias, Alba
   Vazquez-Cobela, Rocio
   Gil-Campos, Mercedes
   Aguilera, Concepcion M.
   Gil, Angel
   Moreno, Luis A.
   Leis, Rosaura
   Bueno, Gloria
TI Dietary Patterns and Their Association with Body Composition and
   Cardiometabolic Markers in Children and Adolescents: Genobox Cohort
SO NUTRIENTS
LA English
DT Article
DE cluster analysis; obesity; diet; anthropometry; inflammation; oxidative
   stress; cardiovascular disease
ID LIFE-STYLE; INSULIN-RESISTANCE; CHILDHOOD OBESITY; EUROPEAN CHILDREN;
   PHYSICAL-ACTIVITY; SPANISH CHILDREN; CLUSTER-ANALYSIS; ABDOMINAL FAT;
   MASS INDEX; DETERMINANTS
AB Diet is a key factor for obesity development; however, limited data are available on dietary cluster analysis in children with obesity. We aimed to assess the associations between dietary patterns and obesity and several cardiometabolic markers. Anthropometry, bioelectrical impedance, blood pressure and plasma biomarkers of oxidative stress, inflammation and endothelial damage were determined in 674 Caucasian children, aged 5-16, with normal or excess weight. Using a food frequency questionnaire and cluster analysis, two consistent dietary patterns were shown, labeled as health conscious (HC) and sweet and processed (SP). The HC pattern included a greater proportion of participants with overweight/obesity than the SP cluster (80.1% vs. 63.8%). However, children with obesity within the HC cluster, showed less abdominal fat, through waist to hip (0.93 vs. 0.94) and waist to height (0.61 vs. 0.63) indexes (p < 0.01). Univariate general models showed several additional differences in cardiometabolic risk biomarkers in the global and stratified analyses, with a healthier profile being observed mainly in the HC cluster. However, multivariate models questioned these findings and pointed out the need for further studies in this field. Anyhow, our findings support the benefits of a healthy diet and highlight the importance of dietary patterns in the cardiometabolic risk assessment of children with overweight/obesity, beyond weight control.
C1 [Latorre-Millan, Miriam; Ruperez, Azahara I.; Gonzalez-Gil, Esther M.; Santaliestra-Pasias, Alba; Moreno, Luis A.; Bueno, Gloria] Univ Zaragoza, GENUD Res Grp, Inst Invest Sanitaria Aragon IIS Aragon, Zaragoza 50013, Spain.
   [Latorre-Millan, Miriam; Bueno, Gloria] Hosp Clin Univ Lozano Blesa, Unidad Endocrinol Pediat, Zaragoza 50009, Spain.
   [Ruperez, Azahara I.; Santaliestra-Pasias, Alba; Moreno, Luis A.; Bueno, Gloria] Inst Agroalimentario Aragon IA2, Zaragoza 50013, Spain.
   [Gonzalez-Gil, Esther M.; Santaliestra-Pasias, Alba; Gil-Campos, Mercedes; Aguilera, Concepcion M.; Gil, Angel; Leis, Rosaura; Bueno, Gloria] Inst Salud Carlos III, Ctr Invest Biomed Red Fisiopatol Obesidad & Nutr, Madrid 28029, Spain.
   [Gonzalez-Gil, Esther M.; Aguilera, Concepcion M.; Gil, Angel] Univ Granada, Ctr Invest Biomed, Inst Nutr & Tecnol Alimentos, Dept Bioquim & Biol Mol 2, Granada 18016, Spain.
   [Vazquez-Cobela, Rocio; Leis, Rosaura] Complejo Hosp Univ Santiago, Inst Invest Sanitaria Santiago Compostela IDIS, Grp Invest Nutr Pediat, Unidad Gastroenterol Hepatol & Nutr Pediat, Santiago De Compostela 15706, Spain.
   [Gil-Campos, Mercedes] Inst Maimonides Invest Biomed Cordoba IMIBIC, Hosp Univ Reina Sofia, Unidad Metabol & Invest Pediat, Cordoba 14071, Spain.
   [Aguilera, Concepcion M.; Gil, Angel] Complejo Hosp Univ Granada, Inst Invest Biosanitaria IBS GRANADA, Granada 18014, Spain.
   [Leis, Rosaura] Univ Santiago de Compostela, Unidad Invest Nutr Crecimiento & Desarrollo Human, Santiago De Compostela 15706, Spain.
C3 Leibniz Association; Leibniz Institute for Prevention Research &
   Epidemiology (BIPS); University of Zaragoza; Lozano Blesa University
   Clinical Hospital; Instituto de Salud Carlos III; CIBER - Centro de
   Investigacion Biomedica en Red; CIBEROBN; University of Granada;
   Complexo Hospitalario Universitario de Santiago de Compostela; Instituto
   de Investigacion Biosanitaria IBS Granada; University of Granada;
   Universidade de Santiago de Compostela
RP Leis, R (corresponding author), Inst Salud Carlos III, Ctr Invest Biomed Red Fisiopatol Obesidad & Nutr, Madrid 28029, Spain.; Leis, R (corresponding author), Complejo Hosp Univ Santiago, Inst Invest Sanitaria Santiago Compostela IDIS, Grp Invest Nutr Pediat, Unidad Gastroenterol Hepatol & Nutr Pediat, Santiago De Compostela 15706, Spain.; Leis, R (corresponding author), Univ Santiago de Compostela, Unidad Invest Nutr Crecimiento & Desarrollo Human, Santiago De Compostela 15706, Spain.
EM latorremiriam0@gmail.com; airuperez@unizar.es; esthergg@ugr.es;
   albasant@unizar.es; cobela.rocio@gmail.com;
   mercedes_gil_campos@yahoo.es; caguiler@ugr.es; agil@ugr.es;
   lmoreno@unizar.es; mariarosaura.leis@usc.es; mgbuenol@unizar.es
RI Moreno, Luis/S-1780-2019; Vázquez-Cobela, Rocío/ABF-5488-2020; BUENO,
   Maria/AAG-9985-2021; Leis, Rosaura/Z-3186-2019; Rupérez,
   Azahara/L-3771-2019; Latorre, Miriam/AAG-4162-2021; Santaliestra-Pasias,
   Alba M/K-7964-2014; Gil, Angel/L-2275-2014; Gonzalez Gil, Esther
   Maria/AAA-8040-2020; Aguilera, Concepcion/M-1663-2014
OI Ruperez, Azahara I./0000-0002-3850-8235; Leis,
   Rosaura/0000-0002-0540-4210; Santaliestra-Pasias, Alba
   M/0000-0002-0303-7912; Gil, Angel/0000-0001-7663-0939; Gonzalez Gil,
   Esther Maria/0000-0003-2005-8229; Latorre-Millan,
   Miriam/0000-0001-9932-0124; Gil-Campos, Mercedes/0000-0002-9007-0242;
   Aguilera, Concepcion/0000-0002-1451-4788; Moreno Aznar, Luis
   A./0000-0003-0454-653X
FU Plan Nacional de Investigacion Cientifica, Desarrollo e Innovacion
   Tecnologica (I+D+I), Instituto de Salud Carlos III-Health Research
   Funding (FONDOS FEDER) [PI05/1968, PI11/01425, PI11/02042, PI11/02059,
   PI16/01301, PI16/01205, PI1600871]; CIBEROBN Network [CB15/00131,
   CB15/00043]; Juan de la Cierva-Formacion from the Spanish Government
   [FJCI-2017-34967, FJCI-2014-19795]; Vice-Rectorate of Research and
   Transfer of the University of Granada, Spain
FX This research was supported by the Plan Nacional de Investigacion
   Cientifica, Desarrollo e Innovacion Tecnologica (I+D+I), Instituto de
   Salud Carlos III-Health Research Funding (FONDOS FEDER) (PI05/1968,
   PI11/01425, PI11/02042, PI11/02059, PI16/01301, PI16/01205 and
   PI1600871); CIBEROBN Network (CB15/00131, CB15/00043). E.M.G.-G. and
   A.I.R. were funded by a Juan de la Cierva-Formacion stipend
   (FJCI-2017-34967 and FJCI-2014-19795, respectively) from the Spanish
   Government. A.G. was co-financed by the Research Plan of the
   Vice-Rectorate of Research and Transfer of the University of Granada,
   Spain.
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NR 66
TC 18
Z9 19
U1 0
U2 11
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD NOV
PY 2020
VL 12
IS 11
AR 3424
DI 10.3390/nu12113424
PG 18
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nutrition & Dietetics
GA OX7XZ
UT WOS:000593774200001
PM 33171599
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Leyva-Vela, B
   Reche-García, C
   Hernández-Morante, JJ
   Martínez-Olcina, M
   Miralles-Amorós, L
   Martínez-Rodríguez, A
AF Leyva-Vela, Belen
   Reche-Garcia, Cristina
   Jose Hernandez-Morante, Juan
   Martinez-Olcina, Maria
   Miralles-Amoros, Laura
   Martinez-Rodriguez, Alejandro
TI Mediterranean Diet Adherence and Eating Disorders in Spanish Nurses with
   Shift Patterns: A Cross-Sectional Study
SO MEDICINA-LITHUANIA
LA English
DT Article
DE mental health; eating disorders; nursing; shift work schedule;
   nutrition; Mediterranean diet; healthy diet; dietary risk
ID METABOLIC SYNDROME; ATTITUDES TEST; TEST EAT-26; LIFE-STYLE; WORK;
   HEALTH; SLEEP; ASSOCIATION; PREVALENCE; QUALITY
AB Background and Objectives: Shift work has a significant influence on the mental health of workers. Nursing is characterised by a rotational work system. This study aimed to determine whether there was a link between adherence to the Mediterranean diet (MD) and the risk of suffering an eating disorder (ED) in nurses according to their work shift. Materials and Methods: A total of 240 women (nurses and nursing assistants) were evaluated and completed the PREDIMED-PLUS questionnaire on adherence to the MD and the EAT-26 (Eating Attitude Test, 26 items). Results: The results indicate that there are no differences in adherence to the MD depending on the work shift, being that adherence to the diet is already low. Statistically significant differences appear depending on the work shift in the following dimensions: restrictive behaviours and bulimia subscales (presenting higher scores in the 7-h rotating shift versus the fixed morning shift or 12-h rotating shift) and for total EAT-26 score. Conclusion: Whilst they do not condition adherence to a MD, the nursing shifts that are the most changing in terms of time patterns may condition restrictive behaviours and compensatory risk behaviours related to an ED.
C1 [Leyva-Vela, Belen] Vinalopo Univ Hosp, Dept Hlth, Elche 03293, Spain.
   [Reche-Garcia, Cristina; Jose Hernandez-Morante, Juan] Catholic Univ Murcia, Fac Nursing, Murcia 30107, Spain.
   [Martinez-Olcina, Maria; Miralles-Amoros, Laura] Univ Alicante, Fac Hlth Sci, Alicante 03690, Spain.
   [Martinez-Rodriguez, Alejandro] Univ Alicante, Fac Sci, Dept Analyt Chem Nutr & Food Sci, Alicante 03690, Spain.
   [Martinez-Rodriguez, Alejandro] ISABIAL Fdn, Alicante Inst Hlth & Biomed Res, Alicante 03010, Spain.
C3 Universidad Catolica de Murcia; Universitat d'Alacant; Universitat
   d'Alacant; General University Hospital of Alicante; Universidad Miguel
   Hernandez de Elche; Universitat d'Alacant; Instituto de Investigacion
   Sanitaria y Biomedica de Alicante (ISABIAL)
RP Martínez-Rodríguez, A (corresponding author), Univ Alicante, Fac Sci, Dept Analyt Chem Nutr & Food Sci, Alicante 03690, Spain.; Martínez-Rodríguez, A (corresponding author), ISABIAL Fdn, Alicante Inst Hlth & Biomed Res, Alicante 03010, Spain.
EM bmleyva@vinaloposalud.com; creche@ucam.edu; jjhernandez@ucam.edu;
   maria.martinezolcina@ua.es; lma52@alu.ua.es; amartinezrodriguez@ua.es
RI Martínez-Rodríguez, Alejandro/AAK-5669-2020; OLCINA,
   MARIA/HCI-7488-2022; , RECHE/O-7687-2016; Hernandez Morante, Juan
   Jose/H-6346-2017
OI , RECHE/0000-0002-4232-8018; LEYVA-VELA, BELEN/0009-0007-5419-4460;
   Hernandez Morante, Juan Jose/0000-0001-9255-4630; Miralles-Amoros,
   Laura/0000-0003-3392-2151; Martinez-Rodriguez,
   Alejandro/0000-0002-7499-1471; del Pino Ortega,
   Daniel/0000-0001-5051-9482
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NR 42
TC 4
Z9 4
U1 4
U2 25
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1010-660X
EI 1648-9144
J9 MEDICINA-LITHUANIA
JI Med. Lith.
PD JUN
PY 2021
VL 57
IS 6
AR 576
DI 10.3390/medicina57060576
PG 9
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA SY6GL
UT WOS:000665984000001
PM 34199973
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Peng, CH
   Lin, HT
   Chung, DJ
   Huang, CN
   Wang, CJ
AF Peng, Chiung-Huei
   Lin, Huei-Ting
   Chung, Dai-Jung
   Huang, Chien-Ning
   Wang, Chau-Jong
TI Mulberry Leaf Extracts prevent obesity-induced NAFLD with regulating
   adipocytokines, inflammation and oxidative stress
SO JOURNAL OF FOOD AND DRUG ANALYSIS
LA English
DT Article
DE Mulberry leaf; Non-alcoholic fatty liver; Adiponectin; Oxidative stress;
   Inflammation
ID FATTY LIVER-DISEASE; METABOLIC SYNDROME; DIET; TISSUE; ACID; MICE;
   MACROPHAGES; LIPOGENESIS; PREVALENCE; INCREASES
AB Mulberry (Morus alba) leaf has been used in Chinese medicine as the remedy for hyperlipidemia and metabolic disorders. Recent report indicated Mulberry leaf extract (MLE) attenuated dyslipidemia and lipid accumulation in high fat diet (HFD)-fed mice. Non-alcoholic fatty liver (NAFLD) is generally considered as the liver component of metabolic syndrome. The hepatic lipid infiltration induces oxidative stress, and is associated with interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) which are regulated by the leptin and adiponectin. MLE could prevent obesity-related NAFLD via downregulating the lipogenesis enzymes while upregulating the lipolysis markers. Treatment of MLE, especially at 2%, enhanced the expression of superoxide dismutase (SOD) and clenched the oxidative stress of liver. MLE decreased the plasma level of leptin but increased adiponectin. The advantage of MLE is supposed mainly attributed to chlorogenic acid derivative. We suggest MLE, with promising outcome of research, could be nutraceutical to prevent obesity and related NAFLD. Copyright (C) 2017, Food and Drug Administration, Taiwan. Published by Elsevier Taiwan LLC. This is an open access article under the CC BY-NC-ND license.
C1 [Peng, Chiung-Huei] Hungkuang Univ, Div Basic Med Sci, 1018,Sec 6,Taiwan Blvd, Taichung 43302, Taiwan.
   [Lin, Huei-Ting; Chung, Dai-Jung; Wang, Chau-Jong] Chung Shan Med Univ, Inst Biochem Microbiol & Immunol, 110,Sect 1,Jianguo North Rd, Taichung 402, Taiwan.
   [Huang, Chien-Ning] Chung Shan Med Univ Hosp, Dept Internal Med, 110,Sect 1,Jianguo North Rd, Taichung 402, Taiwan.
   [Huang, Chien-Ning] Chung Shan Med Univ, Inst Med, 110,Sect 1,Jianguo North Rd, Taichung 402, Taiwan.
   [Wang, Chau-Jong] Chung Shan Med Univ Hosp, Dept Med Res, 110,Sect 1,Jianguo North Rd, Taichung 402, Taiwan.
C3 Hungkuang University; Chung Shan Medical University; Chung Shan Medical
   University; Chung Shan Medical University Hospital; Chung Shan Medical
   University; Chung Shan Medical University; Chung Shan Medical University
   Hospital
RP Wang, CJ (corresponding author), Chung Shan Med Univ, Inst Biochem Microbiol & Immunol, 110,Sect 1,Jianguo North Rd, Taichung 402, Taiwan.; Huang, CN (corresponding author), Chung Shan Med Univ Hosp, Dept Internal Med, 110,Sect 1,Jianguo North Rd, Taichung 402, Taiwan.
EM wcj@csmu.edu.tw
RI 陈, 文杰·/HHN-5495-2022
FU Ministry of Science and Technology, Taiwan [NSC 104-2811-B-040-007]
FX This work was supported by a grant from the Ministry of Science and
   Technology, Taiwan (NSC 104-2811-B-040-007).
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NR 34
TC 70
Z9 76
U1 0
U2 50
PU FOOD & DRUG ADMINSTRATION
PI TAIPEI
PA 161-2 KUNYANG STREET, NANGANG, TAIPEI, 00000, TAIWAN
SN 1021-9498
J9 J FOOD DRUG ANAL
JI J. Food Drug Anal.
PD APR
PY 2018
VL 26
IS 2
BP 778
EP 787
DI 10.1016/j.jfda.2017.10.008
PG 10
WC Food Science & Technology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Pharmacology & Pharmacy
GA GD1MJ
UT WOS:000430263700036
PM 29567249
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Wesley, A
   Bengtsson, C
   Skillgate, E
   Saevarsdottir, S
   Theorell, T
   Holmqvist, M
   Klareskog, L
   Alfredsson, L
   Wedrén, S
AF Wesley, Annmarie
   Bengtsson, Camilla
   Skillgate, Eva
   Saevarsdottir, Saedis
   Theorell, Tores
   Holmqvist, Marie
   Klareskog, Lars
   Alfredsson, Lars
   Wedren, Sara
CA EIRA Study Grp
TI Association Between Life Events and Rheumatoid Arthritis: Results From a
   Population-Based Case-Control Study
SO ARTHRITIS CARE & RESEARCH
LA English
DT Article
ID MYOCARDIAL-INFARCTION; PSYCHOLOGICAL STRESS; SOCIOECONOMIC-STATUS;
   AUTOIMMUNE-DISEASES; PSYCHOSOCIAL STRESS; MULTIPLE-SCLEROSIS; METABOLIC
   SYNDROME; SEX-DIFFERENCES; SWEDISH EIRA; RISK-FACTORS
AB Objective. To investigate the association between life events and the risk for rheumatoid arthritis (RA) with and without antibodies to citrullinated protein (ACPAs).
   Methods. We used data from a population-based case-control study of individuals ages 18-70 years living in geographically defined parts of Sweden between May 1996 and November 2009. We included incident cases (n = 2,774) diagnosed by rheumatologists according to the American College of Rheumatology 1987 criteria for RA and randomly selected controls (n = 3,911) matched to the cases by age, sex, and area of residence. All of the participants answered a questionnaire consisting of questions about 15 life events. We calculated odds ratios (ORs) and 95% confidence intervals (95% CIs) from unconditional logistic regression models adjusted for matching variables and confounding factors.
   Results. Having experienced a life event was weakly associated with ACPA-positive RA as well as ACPA-negative RA (OR 1.1, 95% CI 1.0-1.2 and OR 1.2, 95% CI 1.0-1.4, respectively). The association with ACPA-negative RA was stronger with an increasing number of events (OR 1.4, 95% CI 1.1-1.7 for having experienced >= 3 events versus none). Several particular life events were associated with RA (e. g., "conflict at work," "change of residence," "change of work place," and "increased responsibility at work"). The results were more consistent in women than in men.
   Conclusion. Our study lends support to the concept that certain stressful conditions, here measured as life events, are associated with an increased risk of developing RA.
C1 [Wesley, Annmarie; Bengtsson, Camilla; Skillgate, Eva; Saevarsdottir, Saedis; Theorell, Tores; Holmqvist, Marie; Klareskog, Lars; Alfredsson, Lars; Wedren, Sara] Karolinska Inst, Stockholm, Sweden.
   [Holmqvist, Marie; Klareskog, Lars; Wedren, Sara] Karolinska Univ Hosp Solna, Stockholm, Sweden.
   [Alfredsson, Lars] Stockholm Cty Council, Stockholm, Sweden.
C3 Karolinska Institutet; Karolinska Institutet; Karolinska University
   Hospital; Region Stockholm
RP Wesley, A (corresponding author), Box 210, S-17177 Stockholm, Sweden.
EM annmarie.wesley@ki.se
RI Alfredsson, Lars/AAC-9007-2019; Bengtsson, Camilla/A-8475-2015;
   Holmqvist, Marie/D-4508-2017
OI Holmqvist, Marie/0000-0001-8996-5260; Alfredsson,
   Lars/0000-0003-1688-6697
FU Swedish Research Council; Stockholm County Council; Swedish Rheumatism
   Association; Research Council for Social and Occupational Sciences
FX Supported by the Swedish Research Council, the Stockholm County Council,
   the Swedish Rheumatism Association (patient organization), and the
   Research Council for Social and Occupational Sciences.
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NR 49
TC 6
Z9 6
U1 0
U2 12
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2151-464X
EI 2151-4658
J9 ARTHRIT CARE RES
JI Arthritis Care Res.
PD JUN
PY 2014
VL 66
IS 6
BP 844
EP 851
DI 10.1002/acr.22230
PG 8
WC Rheumatology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Rheumatology
GA AJ8RV
UT WOS:000337975700008
DA 2025-06-11
ER

PT J
AU Frasch, K
   Larsen, JI
   Cordes, J
   Jacobsen, B
   Jensen, SOW
   Lauber, C
   Nielsen, JA
   Tsuchiya, KJ
   Uwakwe, R
   Munk-Jorgensen, P
   Kilian, R
   Becker, T
AF Frasch, Karel
   Larsen, Jens Ivar
   Cordes, Joachim
   Jacobsen, Bent
   Jensen, Signe Olrik Wallenstein
   Lauber, Christoph
   Nielsen, Jorgen Achton
   Tsuchiya, Kenji J.
   Uwakwe, Richard
   Munk-Jorgensen, Povl
   Kilian, Reinhold
   Becker, Thomas
TI Physical illness in psychiatric inpatients: Comparison of patients with
   and without substance use disorders
SO INTERNATIONAL JOURNAL OF SOCIAL PSYCHIATRY
LA English
DT Article
DE Substance use disorders; somatic comorbidity; physical illness; somatic
   health risks; psychiatric inpatients
ID ALCOHOL-CONSUMPTION; MENTAL-ILLNESS; RISK-FACTORS; METABOLIC SYNDROME;
   PRIMARY-CARE; HEALTH; CANNABIS; DISEASE; PEOPLE; BURDEN
AB Background: Physical comorbidities and substance use are commonly reported in patients with mental disorders.
   Aim: To examine somatic comorbidity in patients with substance use disorders (SUD) compared to patients with mental disorders but no SUD.
   Methods: Lifetime prevalence data on mental and physical health status were collected from inpatients in 12 mental health care facilities in five different countries. Differences in somatic comorbidity were examined by means of logistic regression analysis controlling for age and gender.
   Results: Of 2,338 patients, 447 (19%) had a primary or secondary SUD diagnosis. In comparison to patients with other mental disorders, patients with SUD had a higher prevalence of infectious and digestive diseases but a lower prevalence of endocrine, nutritional and metabolic disorders. Patterns of physical comorbidities differed according to type of substance used (alcohol use - cardiovascular; tobacco use - respiratory, neoplasms; cannabinoid use - injuries; opioid use - infectious, digestive; benzodiazepine use - endocrine, nutritional, metabolic; stimulants - urogenital).
   Conclusions: SUD are related to specific somatic health risks while some of our findings point to potentially protective effects. The widespread prescription of benzodiazepines requires research on physical health effects. Early detection of SUD and their integration into programmes targeting physical comorbidity should be a priority in organizing mental health care.
C1 [Frasch, Karel; Kilian, Reinhold; Becker, Thomas] Univ Ulm, Dept Psychiat 2, D-89312 Gunzburg, Germany.
   [Larsen, Jens Ivar; Jensen, Signe Olrik Wallenstein; Munk-Jorgensen, Povl] Aarhus Univ Hosp, Aalborg Psychiat Hosp, Aalborg, Denmark.
   [Cordes, Joachim] Univ Dusseldorf, Dept Psychiat & Psychotherapy, Dusseldorf, Germany.
   [Jacobsen, Bent] Aarhus Univ Hosp, Aalborg Hosp, Dept Med Gastroenterol, Aalborg, Denmark.
   [Lauber, Christoph] Univ Liverpool, Liverpool L69 3BX, Merseyside, England.
   [Nielsen, Jorgen Achton] Aarhus Univ Hosp, Risskov, Denmark.
   [Tsuchiya, Kenji J.] Hamamatsu Univ Sch Med, Hamamatsu, Shizuoka 4313192, Japan.
   [Uwakwe, Richard] Nnamdi Azikiwe Univ, Awka, Nigeria.
C3 Ulm University; Aalborg University; Aalborg University Hospital; Aarhus
   University; Aarhus Psychiatric Hospital; Heinrich Heine University
   Dusseldorf; Aarhus University; Aalborg University; Aalborg University
   Hospital; University of Liverpool; Aarhus University; Hamamatsu
   University School of Medicine
RP Frasch, K (corresponding author), Univ Ulm, Dept Psychiat 2, Bezirkskrankenhaus Gunzburg, Ludwig Heilmeyer Str 2, D-89312 Gunzburg, Germany.
EM karel.frasch@bkh-guenzburg.de
RI Becker, Thomas/O-9769-2014; Tsuchiya, Kenji/I-9123-2019
OI Tsuchiya, Kenji/0000-0002-1314-4199
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NR 28
TC 19
Z9 21
U1 1
U2 15
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0020-7640
EI 1741-2854
J9 INT J SOC PSYCHIATR
JI Int. J. Soc. Psychiatr.
PD DEC
PY 2013
VL 59
IS 8
BP 757
EP 764
DI 10.1177/0020764012456803
PG 8
WC Psychiatry
WE Social Science Citation Index (SSCI)
SC Psychiatry
GA 256FC
UT WOS:000327294100005
PM 23034284
DA 2025-06-11
ER

PT J
AU Wang, P
   Ma, XM
   Geng, K
   Jiang, ZZ
   Yan, PY
   Xu, Y
AF Wang, Peng
   Ma, Xiu Mei
   Geng, Kang
   Jiang, Zong Zhe
   Yan, Pei Yu
   Xu, Yong
TI Effects of Camellia tea and herbal tea on cardiometabolic risk in
   patients with type 2 diabetes mellitus: A systematic review and
   meta-analysis of randomized controlled trials
SO PHYTOTHERAPY RESEARCH
LA English
DT Review
DE Camellia; herbal tea; meta-analysis; metabolism; type 2 diabetes
ID C-REACTIVE PROTEIN; GREEN TEA; BLOOD-PRESSURE; BLACK TEA; OXIDATIVE
   STRESS; GLUCOSE CONTROL; CONSUMPTION; BIOMARKERS; EXTRACT; ADIPONECTIN
AB Evidence for the anti-diabetic actions of camellia and herbal tea in diabetic patients has not been summarized. Several data sources were searched for randomized trials assessing the effect of different teas on cardiometabolic risk factors in T2D subjects. Two independent reviewers extracted relevant data and assessed the risk of bias. Results were summarized using mean differences (MDs) based on a random model. Sixteen studies (19 trials, N = 832) fulfilled the eligibility criteria. Mean differences were measured for body weight, body mass index, fasting blood glucose, glycosylated hemoglobin, a homeostatic model for insulin resistance, high and low-density lipoproteins, triglycerides, and systolic and diastolic blood pressure. No effects on total cholesterol and waist circumference were observed when either camellia or herbal tea was consumed. Tea produced moderate regulatory effects on adipose, glycemic control, lipid profiles, and blood pressure. In terms of efficacy, camellia and herbal teas yield different benefits in regulating metabolism. This discovery has some implications for clinical research and drug development. However, more high-quality trials are needed to improve the certainty of our estimates.
C1 [Wang, Peng; Ma, Xiu Mei; Geng, Kang; Yan, Pei Yu; Xu, Yong] Macau Univ Sci & Technol, Fac Chinese Med, Ave Wai Long, Taipa, Macau, Peoples R China.
   [Wang, Peng; Ma, Xiu Mei; Geng, Kang; Yan, Pei Yu; Xu, Yong] Macau Univ Sci & Technol, Fac Chinese Med, State Key Lab Qual Res Chinese Med, Macau, Peoples R China.
   [Ma, Xiu Mei; Jiang, Zong Zhe; Xu, Yong] Southwest Med Univ, Dept Endocrinol & Metab, Affiliated Hosp, Luzhou, Sichuan, Peoples R China.
   [Ma, Xiu Mei; Geng, Kang; Jiang, Zong Zhe; Xu, Yong] Southwest Med Univ, Metab Vasc Dis Key Lab Sichuan Prov, Affiliated Hosp, Luzhou, Sichuan, Peoples R China.
   [Ma, Xiu Mei; Geng, Kang; Jiang, Zong Zhe; Xu, Yong] Southwest Med Univ, Sichuan Clin Res Ctr Nephropathy, Affiliated Hosp, Luzhou, Sichuan, Peoples R China.
   [Geng, Kang] Southwest Med Univ, Dept Plast & Burn Surg, Affiliated Hosp, Luzhou, Sichuan, Peoples R China.
C3 Macau University of Science & Technology; Macau University of Science &
   Technology; Southwest Medical University; Southwest Medical University;
   Southwest Medical University; Southwest Medical University
RP Yan, PY; Xu, Y (corresponding author), Macau Univ Sci & Technol, Fac Chinese Med, Ave Wai Long, Taipa, Macau, Peoples R China.
EM pyyan@must.edu.mo; xywyll@swmu.edu.cn
RI Xu, Yong/AGX-9165-2022
FU Luzhou-Southwest Medical University cooperation project [2018LZXNYD-PT
   01]; National Natural Science Foundation of China [81970676]; Sichuan
   Science and Technology Program [2019YFS0537, 2020YFS0456]
FX Luzhou-Southwest Medical University cooperation project, Grant/Award
   Number: 2018LZXNYD-PT 01; National Natural Science Foundation of China,
   Grant/Award Number: 81970676; Sichuan Science and Technology Program,
   Grant/Award Numbers: 2019YFS0537, 2020YFS0456
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NR 60
TC 18
Z9 19
U1 4
U2 29
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0951-418X
EI 1099-1573
J9 PHYTOTHER RES
JI Phytother. Res.
PD NOV
PY 2022
VL 36
IS 11
BP 4051
EP 4062
DI 10.1002/ptr.7572
EA OCT 2022
PG 12
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 6F1JM
UT WOS:000863882400001
PM 36197117
DA 2025-06-11
ER

PT J
AU Boyne, MS
   Woollard, A
   Phillips, DIW
   Taylor-Bryan, C
   Bennett, FI
   Osmond, C
   Thomas, TYR
   Wilks, RJ
   Forrester, TE
AF Boyne, Michael S.
   Woollard, Alexander
   Phillips, David I. W.
   Taylor-Bryan, Carolyn
   Bennett, Franklyn I.
   Osmond, Clive
   Thomas, Tamika Y. Royal
   Wilks, Rainford J.
   Forrester, Terrence E.
TI The association of hypothalamic-pituitary-adrenal axis activity and
   blood pressure in an Afro-Caribbean population
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE Cortisol; Blood pressure; Fetus; Birth weight; Jamaica
ID LOW-BIRTH-WEIGHT; PLASMA-CORTISOL CONCENTRATIONS; PSYCHOLOGICAL STRESS;
   BODY-COMPOSITION; PRENATAL STRESS; CHILDREN; GROWTH; GLUCOCORTICOIDS;
   HYPERTENSION; PREGNANCIES
AB Hyperactivity of the hypothalamic-pituitary-adrenal axis (HPAA) resulting from fetal programming may play a rote in the development of high blood pressure (BP) in black people. We assessed the diurnal salivary cortisol profile in children with and without increased BP and evaluated their mother's HPAA. In a cross-sectional study, 20 Afro-Caribbean children (mean age 9.6 years) with higher blood pressures and 20 children with lower blood pressures were chosen from a prospective study of 569 mothers and children in Jamaica. Daytime salivary cortisol profiles were collected in the children and their mothers. The mothers were also assessed for features of the metabolic syndrome.
   Children with higher BP had higher mean morning salivary cortisol concentrations than those with lower BP (7.9 S.D. 1.9 vs. 4.5 S.D. 2.4 nmol/l; p = 0.03). Their mothers also had increased morning salivary cortisol concentrations (9.9 S.D. 1.8 vs. 5.5 S.D. 2.5 nmol/l; p = 0.02), but no changes in fasting glucose, insulin, lipids, BP or adiposity. Maternal and offspring cortisol concentrations correlated significantly (r = 0.465, p = 0.004). Maternal cortisol concentrations were significantly associated with the child's BP. We conclude that Afro-Caribbean children with higher BP have higher morning salivary cortisol concentrations. The children's cortisol concentrations correlate significantly with the mother's cortisol concentrations. These findings suggest that the HPAA may play a role in the development of raised BP in Afro-Caribbean people. (C) 2008 Elsevier Ltd. All rights reserved.
C1 [Boyne, Michael S.; Taylor-Bryan, Carolyn; Bennett, Franklyn I.; Thomas, Tamika Y. Royal; Wilks, Rainford J.; Forrester, Terrence E.] Univ W Indies, Res Inst Trop Med, Mona 7, Kingston, Jamaica.
   [Woollard, Alexander; Phillips, David I. W.; Osmond, Clive] Univ Southampton, MRC, Epidemiol Resource Ctr, Southampton SO9 5NH, Hants, England.
C3 University West Indies Mona Jamaica; University of Southampton
RP Boyne, MS (corresponding author), Univ W Indies, Res Inst Trop Med, Mona 7, Kingston, Jamaica.
EM rnichael.boyne@uwimona.edu.jm
RI Woollard, Alex/I-3925-2019; Boyne, Michael/I-2242-2013
OI Osmond, Clive/0000-0002-9054-4655; Woollard, Alex/0000-0002-7917-6353;
   Boyne, Michael/0000-0002-5227-2492
FU Caribbean Health Research Council; The Association of Physicians, UK and
   Ireland
FX This work was supported by grants from the Caribbean Health Research
   Council and The Association of Physicians, UK and Ireland. These
   organizations had no role in study design; in the collection, analysis
   and interpretation of data; in the writing of the report; and in the
   decision to submit the paper for publication.
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NR 38
TC 21
Z9 22
U1 0
U2 1
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD JUN
PY 2009
VL 34
IS 5
BP 736
EP 742
DI 10.1016/j.psyneuen.2008.12.005
PG 7
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA 444BC
UT WOS:000265953900011
PM 19155140
DA 2025-06-11
ER

PT J
AU Visweswaraiah, N
   Nathan, K
AF Visweswaraiah, Naveen
   Nathan, Kousalya
TI Adolescent Obesity and Eating Disorders: Can Calorie Restriction have a
   Positive Impact
SO CURRENT NUTRITION & FOOD SCIENCE
LA English
DT Review
DE Adolescent; calorie restriction; eating disorder; obesitis; overweight;
   stress
ID LOW-CARBOHYDRATE-DIET; BODY-MASS INDEX; CARDIOVASCULAR RISK-FACTORS;
   WEIGHT-LOSS; CHILDHOOD OBESITY; MOLECULAR-MECHANISMS;
   SOCIOECONOMIC-STATUS; BEHAVIORAL TREATMENT; METABOLIC SYNDROME;
   PHYSICAL-ACTIVITY
AB Background: The current obesogenic environment with relatively increased affordability and availability of high calorie food and beverages, has led to an alarming increase in the prevalence of obesity and related lifestyle disorders in children and adolescents, predisposing them to accelerated aging. The increased prevalence may be due to the eating behavior of adolescents, their genetic and molecular etiology and/or due to the impact of psychological stress and their wrong lifestyle choices. Calorie restriction has been extensively researched for reducing the obesity in adolescents and adults but is yet to be successfully implemented.
   Objective: The present review paper focuses on the types of calorie restriction diets, the role of its mimics and the nutrigenomic mechanisms that may be helpful in reducing obesity and related disorders in the adolescents. The role of behavioral therapeutic techniques and physical activity has also been highlighted in addition to the calorie restricted diet for bringing about an overall lifestyle modification in the management of obesity.
   Conclusion: Food preferences are acquired in childhood and sound nutritional practices should be established in childhood to prevent lifestyle disorders and premature aging. Though CR is a known and preferred non-pharmacological intervention in the management of obesity, its implemention has not been explored and evaluated extensively. This is a vital area that needs scientific research as the goals of obesity managements are no longer just weight loss through dietary restrictions. An interdisciplinary method to lifestyle modification in the management of adolescent obesity addressing all physiological and psychosocial aspects is recommended.
C1 [Visweswaraiah, Naveen] Fdn Assessment & Integrat Tradit Hlth Syst, Bengaluru 560027, Karnataka, India.
   [Nathan, Kousalya] Apollo Spectra Hosp, Dept Lifestyle Management, Chennai 600028, Tamil Nadu, India.
RP Nathan, K (corresponding author), Apollo Spectra Hosp, Dept Lifestyle Management, Chennai 600028, Tamil Nadu, India.
EM kousalya.researche@gmail.com
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NR 112
TC 0
Z9 0
U1 0
U2 11
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1573-4013
EI 2212-3881
J9 CURR NUTR FOOD SCI
JI Curr. Nutr. Food Sci.
PY 2020
VL 16
IS 4
BP 433
EP 443
DI 10.2174/1573401315666190114153400
PG 11
WC Nutrition & Dietetics
WE Emerging Sources Citation Index (ESCI)
SC Nutrition & Dietetics
GA MN6YI
UT WOS:000550991000002
DA 2025-06-11
ER

PT J
AU Smith, DL
   Graham, EL
   Douglas, JA
   Jack, K
   Conner, MJ
   Arena, R
   Chaudhry, S
AF Smith, Denise L.
   Graham, Elliot L.
   Douglas, Julie A.
   Jack, Kepra
   Conner, Michael J.
   Arena, Ross
   Chaudhry, Sundeep
TI Subclinical Cardiac Dysfunction is Associated with Reduced
   Cardiorespiratory Fitness and Cardiometabolic Risk Factors in
   Firefighters
SO AMERICAN JOURNAL OF MEDICINE
LA English
DT Article
DE Cardiac dysfunction; Firefighters; Prevention; Risk stratification;
   Stress testing
ID CORONARY MICROVASCULAR DYSFUNCTION; ENDOTHELIAL DYSFUNCTION; SCIENTIFIC
   STATEMENT; MYOCARDIAL-ISCHEMIA; ARTERY-DISEASE; HEALTHY-MEN; RESISTANCE;
   MORTALITY
AB BACKGROUND: Past studies have documented the ability of cardiopulmonary exercise testing to detect cardiac dysfunction in symptomatic patients with coronary artery disease. Firefighters are at high risk for work-related cardiac events. This observational study investigated the association of subclinical cardiac dysfunction detected by cardiopulmonary exercise testing with modifiable cardiometabolic risk factors in asymptomatic firefighters.
   METHODS: As part of mandatory firefighter medical evaluations, study subjects were assessed at 2 occupational health clinics serving 21 different fire departments. Mixed effects logistic regression analyses were used to estimate odds ratios (ORs) and account for clustering by fire department.
   RESULTS: Of the 967 male firefighters (ages 20-60 years; 84% non-Hispanic white; 14% on cardiovascular medications), nearly two-thirds (63%) had cardiac dysfunction despite having normal predicted cardiorespiratory fitness (median peak VO2 = 102%). In unadjusted analyses, cardiac dysfunction was significantly associated with advanced age, obesity, diastolic hypertension, high triglycerides, low high-density lipoprotein (HDL) cholesterol, and reduced cardiorespiratory fitness (all P values <.05). After adjusting for age and ethnicity, the odds of having cardiac dysfunction were approximately one-third higher among firefighters with obesity and diastolic hypertension (OR = 1.39, 95% confidence interval [CI] = 1.03-1.87 and OR = 1.36, 95% CI = 1.03-1.80) and more than 5 times higher among firefighters with reduced cardiorespiratory fitness (OR = 5.41, 95% CI = 3.29-8.90).
   CONCLUSION: Subclinical cardiac dysfunction detected by cardiopulmonary exercise testing is a common finding in career firefighters and is associated with substantially reduced cardiorespiratory fitness and cardiometabolic risk factors. These individuals should be targeted for aggressive risk factor modification to increase cardiorespiratory fitness as part of an outpatient prevention strategy to improve health and safety. (C) 2022 The Authors. Published by Elsevier Inc.
C1 [Smith, Denise L.; Graham, Elliot L.] Skidmore Coll, Dept Hlth & Human Physiol Sci, Responder Hlth & Safety Lab 1, Saratoga Springs, NY 12866 USA.
   [Douglas, Julie A.] Skidmore Coll, Dept Math & Stat, Saratoga Springs, NY 12866 USA.
   [Douglas, Julie A.] Univ Michigan, Dept Human Genet, Ann Arbor, MI 48109 USA.
   [Jack, Kepra] Heart Fit Duty, Mesa, AZ USA.
   [Conner, Michael J.] Front Line Mobile Hlth PLLC, Georgetown, TX USA.
   [Arena, Ross] Univ Illinois, Dept Phys Therapy, Coll Appl Hlth Sci, Chicago, IL USA.
   [Arena, Ross; Chaudhry, Sundeep] Hlth Living Pandem Event Protect HL PIVOT Network, Chicago, IL USA.
   [Chaudhry, Sundeep] MET TEST, Res & Dev, Atlanta, GA USA.
C3 Skidmore College; Skidmore College; University of Michigan System;
   University of Michigan; University of Illinois System; University of
   Illinois Chicago; University of Illinois Chicago Hospital
RP Chaudhry, S (corresponding author), 1455 Old Alabama Rd,Suite 160, Roswell, GA 30076 USA.
EM schaudhry@mettest.net
RI Chaudhry, Sundeep/AAB-8378-2020; Arena, Ross/A-3141-2008
OI Arena, Ross/0000-0002-6675-1996; Conner, Michael/0009-0000-6870-1485
FU Federal Emergency Management Agency [EMW-2017-FP-PP-00445]
FX This work was supported by a grant from the Federal Emergency Management
   Agency [EMW-2017-FP-PP-00445]. The funding source had no role in the
   study design; in the collection, analysis, and interpretation of data;
   in writing the report; and in the decision to submit the article for
   publication.
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NR 39
TC 12
Z9 12
U1 1
U2 3
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0002-9343
EI 1555-7162
J9 AM J MED
JI Am. J. Med.
PD JUN
PY 2022
VL 135
IS 6
BP 752
EP +
DI 10.1016/j.amjmed.2021.12.025
EA MAY 2022
PG 12
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 3I8VX
UT WOS:000832988000034
PM 35134370
OA hybrid
DA 2025-06-11
ER

PT J
AU Fotis, L
   Giannakopoulos, D
   Stamogiannou, L
   Xatzipsalti, M
AF Fotis, Lampros
   Giannakopoulos, Dionysios
   Stamogiannou, Lela
   Xatzipsalti, Maria
TI Intercellular cell adhesion molecule-1 and vascular cell adhesion
   molecule-1 in children. Do they play a role in the progression of
   atherosclerosis?
SO HORMONES-INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM
LA English
DT Review
DE Atherosclerosis; Cell adhesion molecules; Childhood obesity; Diabetes
   mellitus; Hypercholesterolemia; Intercellular adhesion molecule-1; Type
   1; Vascular cell adhesion molecule-1
ID CORONARY-HEART-DISEASE; INSULIN-RESISTANCE; ENDOTHELIAL DYSFUNCTION;
   OBESE CHILDREN; E-SELECTIN; PLASMA-CONCENTRATION; METABOLIC SYNDROME;
   OXIDATIVE STRESS; YOUNG-ADULTS; RISK-FACTORS
C1 [Fotis, Lampros; Stamogiannou, Lela; Xatzipsalti, Maria] P & A Kyriakou Childrens Hosp, Dept Pediat 1, Athens, Greece.
RP Xatzipsalti, M (corresponding author), 1 Zafeiriou Str, Athens 17122, Greece.
EM marax5873@hotmail.co.uk
RI Fotis, Lampros/AAK-8414-2021
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NR 66
TC 22
Z9 25
U1 0
U2 9
PU SPRINGER INTERNATIONAL PUBLISHING AG
PI CHAM
PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND
SN 1109-3099
EI 2520-8721
J9 HORM-INT J ENDOCRINO
JI Horm.-Int. J. Endocrinol. Metab.
PD APR-JUN
PY 2012
VL 11
IS 2
BP 140
EP 146
DI 10.14310/horm.2002.1340
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 970UT
UT WOS:000306158500002
PM 22801559
OA Bronze
DA 2025-06-11
ER

PT J
AU El-Wakf, AM
   El-Sawi, MR
   El-Nigomy, HM
   El-Nashar, EM
   Al-Zahrani, NS
   Alqahtani, NG
   Aldahhan, RA
   Eldken, ZH
AF El-Wakf, Azza Mohamad
   El-Sawi, Mamdouh Rashad
   El-Nigomy, Hadeer Mahmoud
   El-Nashar, Eman Mohamad
   Al-Zahrani, Norah Saeed
   Alqahtani, Nasser G.
   Aldahhan, Rashid A.
   Eldken, Zienab Helmy
TI Fennel seeds extract prevents fructose-induced cardiac dysfunction in a
   rat model of metabolic syndrome via targeting abdominal obesity,
   hyperuricemia and NF- κβ inflammatory pathway
SO TISSUE & CELL
LA English
DT Article
DE Fructose; Metabolic syndrome; Cardiac hypertrophy; Hyperuricemia; NF;
   kappa beta pathway; Fennel seeds
ID REDOX HOMEOSTASIS; OXIDATIVE STRESS; ANTIOXIDANT; ACID
AB Background: Metabolic syndrome (MetS) is commonly associated with increased risk of cardiac disease that affects a large number of world populations. Objective: This research attempted to investigate the efficacy of fennel seeds extract (FSE) in preventing development of cardiac dysfunction in rats on fructose enriched diet for 3 months, as a model of MetS. Materials & methods: Thirty adult Wistar male rats (160-170 g) were assigned into 5 groups including control, vehicle, FSE (200 mg/kg BW) and fructose (60%) fed rats with and without FSE. Following the last treatment, blood pressure, ECG and heart rate were measured. Next, blood and cardiac tissues were taken for biochemical and histological investigations. Results: Feeding fructose exhibited characteristic features of MetS involving, hypertension, abnormal ECG, elevated heart rate, serum glucose, insulin, lipids and insulin resistance, accompanied by abdominal obesity, cardiac hypertrophy and hyperuricemia. Fructose fed rats also showed significant reduction in cardiac antioxidants (GSH, SOD, CAT) with elevation in oxidative stress indices (NADPH oxidase, O2.-, H2O2, MDA, PCO), NF-kappa beta, pro-inflammatory cytokines (TNF-alpha, IL-1 beta, IL-6), adhesion molecules (ICAM-1, VCAM-1) and serum cardiac biomarkers (AST, LDH, CK-MB, cTn-I). Histopathological changes evidenced by destruction of cardiac myofibrils, cytoplasmic vacuolization, and aggregation of inflammatory cells were also detected. Consumption of FSE showed high ability to alleviate fructose-induced hypertension, ECG abnormalities, cardiac hypertrophy, metabolic alterations, oxidative stress, inflammation and histological injury. Conclusion: Findings could suggest FSE as a complementary supplement for preventing MetS and associated cardiac outcomes. However, well controlled clinical studies are still needed.
C1 [El-Wakf, Azza Mohamad; El-Sawi, Mamdouh Rashad; El-Nigomy, Hadeer Mahmoud] Mansoura Univ, Fac Sci, Dept Zool, Mansoura, Egypt.
   [El-Nashar, Eman Mohamad; Al-Zahrani, Norah Saeed] King Khalid Univ, Coll Med, Dept Anat, Abha 62529, Saudi Arabia.
   [Alqahtani, Nasser G.] King Khalid Univ, Coll Med, Dept Clin Biochem, Abha 62529, Saudi Arabia.
   [Alqahtani, Nasser G.] King Khalid Univ, Coll Med, Dept Internal Med, Cardiol, Abha 62529, Saudi Arabia.
   [Aldahhan, Rashid A.] Imam Abdulrahman Bin Faisal Univ, Coll Med, Dept Anat, POB 2114, Dammam 31451, Saudi Arabia.
   [Eldken, Zienab Helmy] Mansoura Univ, Fac Med, Dept Med Physiol, Mansoura, Egypt.
   [Eldken, Zienab Helmy] Ibn Sina Univ Med Sci, Dept Basic Med Sci, Amman 11104, Jordan.
C3 Egyptian Knowledge Bank (EKB); Mansoura University; King Khalid
   University; King Khalid University; King Khalid University; Imam
   Abdulrahman Bin Faisal University; Egyptian Knowledge Bank (EKB);
   Mansoura University
RP El-Wakf, AM (corresponding author), Mansoura Univ, Fac Sci, Dept Zool, Mansoura, Egypt.; El-Nashar, EM (corresponding author), King Khalid Univ, Coll Med, Dept Anat, Abha 62529, Saudi Arabia.; Eldken, ZH (corresponding author), Mansoura Univ, Fac Med, Dept Med Physiol, Mansoura, Egypt.; Eldken, ZH (corresponding author), Ibn Sina Univ Med Sci, Dept Basic Med Sci, Amman 11104, Jordan.
EM drazza_elwakf@yahoo.com; enshar@kku.edu.sa; zienabeldken@yahoo.com
RI Aldahhan, Rashid/AAJ-3502-2021; Al-Zahrani, Norah/MBG-4909-2025; El
   Nashar, Eman/AAC-5855-2022; Alqahtani, Nasser G/GRY-4347-2022
OI El Nashar, Eman/0000-0002-2883-6761; Al-Zahrani, Dr. Norah
   Saeed/0009-0001-3180-4998; Alqahtani, Nasser G/0000-0003-2302-2651
FU Deanship of Scientific Research at King Khalid University [RGP2/291/44]
FX This work was funded by Deanship of Scientific Research at King Khalid
   University for Funding this work through large group Research Project
   under grant number RGP2/291/44.
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NR 57
TC 1
Z9 1
U1 1
U2 5
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0040-8166
J9 TISSUE CELL
JI Tissue Cell
PD JUN
PY 2024
VL 88
AR 102385
DI 10.1016/j.tice.2024.102385
EA APR 2024
PG 12
WC Anatomy & Morphology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Anatomy & Morphology; Cell Biology
GA SP9Y7
UT WOS:001235784300001
PM 38678740
DA 2025-06-11
ER

PT J
AU Kiyooka, T
   Ohanyan, V
   Yin, LY
   Pung, YF
   Chen, YR
   Chen, CL
   Kang, PT
   Hardwick, JP
   Yun, JN
   Janota, D
   Peng, J
   Kolz, C
   Guarini, G
   Wilson, G
   Shokolenko, I
   Stevens, DA
   Chilian, WM
AF Kiyooka, Takahiko
   Ohanyan, Vahagn
   Yin, Liya
   Pung, Yuh Fen
   Chen, Yeong-Renn
   Chen, Chwen-Lih
   Kang, Patrick T.
   Hardwick, James P.
   Yun, June
   Janota, Danielle
   Peng, Joanna
   Kolz, Christopher
   Guarini, Giacinta
   Wilson, Glenn
   Shokolenko, Inna
   Stevens, Donte A.
   Chilian, William M.
TI Mitochondrial DNA integrity and function are critical for
   endothelium-dependent vasodilation in rats with metabolic syndrome
SO BASIC RESEARCH IN CARDIOLOGY
LA English
DT Article
DE Endothelium; Endothelial dysfunction; Mitochondria; Diabetes; Metabolic
   syndrome
ID ACTIVATED PROTEIN-KINASE; NITRIC-OXIDE SYNTHESIS; OXIDATIVE STRESS;
   CARDIOVASCULAR-DISEASE; ANTIOXIDANT VITAMINS; CARDIAC MYOCYTES; REACTIVE
   OXYGEN; DYSFUNCTION; ATHEROSCLEROSIS; HYPERTENSION
AB Endothelial dysfunction in diabetes is generally attributed to oxidative stress, but this view is challenged by observations showing antioxidants do not eliminate diabetic vasculopathy. As an alternative to oxidative stress-induced dysfunction, we interrogated if impaired mitochondrial function in endothelial cells is central to endothelial dysfunction in the metabolic syndrome. We observed reduced coronary arteriolar vasodilation to the endothelium-dependent dilator, acetylcholine (Ach), in Zucker Obese Fatty rats (ZOF, 34 +/- 15% [mean +/- standard deviation] 10(-3) M) compared to Zucker Lean rats (ZLN, 98 +/- 11%). This reduction in dilation occurred concomitantly with mitochondrial DNA (mtDNA) strand lesions and reduced mitochondrial complex activities in the endothelium of ZOF versus ZLN. To demonstrate endothelial dysfunction is linked to impaired mitochondrial function, administration of a cell-permeable, mitochondria-directed endonuclease (mt-tat-EndoIII), to repair oxidatively modified DNA in ZOF, restored mitochondrial function and vasodilation to Ach (94 +/- 13%). Conversely, administration of a cell-permeable, mitochondria-directed exonuclease (mt-tat-ExoIII) produced mtDNA strand breaks in ZLN, reduced mitochondrial complex activities and vasodilation to Ach in ZLN (42 +/- 16%). To demonstrate that mitochondrial function is central to endothelium-dependent vasodilation, we introduced (via electroporation) liver mitochondria (from ZLN) into the endothelium of a mesenteric vessel from ZOF and restored endothelium-dependent dilation to vasoactive intestinal peptide (VIP at 10(-5) M, 4 +/- 3% vasodilation before mitochondrial transfer and 48 +/- 36% after transfer). Finally, to demonstrate mitochondrial function is key to endothelium-dependent dilation, we administered oligomycin (mitochondrial ATP synthase inhibitor) and observed a reduction in endothelium-dependent dilation. We conclude that mitochondrial function is critical for endothelium-dependent vasodilation.
C1 [Kiyooka, Takahiko] Tokai Univ Oiso Hosp, Div Cardiol, Oiso, Kanagawa, Japan.
   [Ohanyan, Vahagn; Yin, Liya; Chen, Yeong-Renn; Chen, Chwen-Lih; Kang, Patrick T.; Hardwick, James P.; Yun, June; Janota, Danielle; Peng, Joanna; Kolz, Christopher; Chilian, William M.] Northeast Ohio Med Univ, Dept Integrat Med Sci, Rootstown, OH 44274 USA.
   [Pung, Yuh Fen] Univ Nottingham, Div Biomed Sci, Malaysia Campus, Semenyih, Selangor, Malaysia.
   [Guarini, Giacinta] Cardiovasc Unit, Spedali Riuniti Santa Maria Maddalena, Volterra, Italy.
   [Wilson, Glenn; Shokolenko, Inna] Univ S Alabama, Dept Biomed Sci, Mobile, AL USA.
   [Stevens, Donte A.] Univ Calif San Diego, Div Biol Sci, San Diego, CA 92103 USA.
C3 University System of Ohio; Northeast Ohio Medical University (NEOMED);
   University of Nottingham Malaysia; University of South Alabama;
   University of California System; University of California San Diego
RP Chilian, WM (corresponding author), Northeast Ohio Med Univ, Dept Integrat Med Sci, Rootstown, OH 44274 USA.
EM wchilian@neomed.edu
RI Guarini, Giacinta/J-7542-2016; Pung, Yuh Fen/E-8959-2016
OI Pung, Yuh Fen/0000-0001-6195-3970; Kang, Patrick/0000-0002-1806-8367;
   Stevens, Donte Alexander/0000-0002-3732-9972
FU Schermer Family Trust [HL135024, HL135110, HL137008, HL142710]; Fibus
   Family Foundation; National Heart Lung and Blood Institute [R01HL142710,
   R01HL137008] Funding Source: NIH RePORTER
FX The authors acknowledge the following sources of funding: HL135024,
   HL135110 (WMC); HL135110, HL137008 (LY); HL142710 (VO). We also
   acknowledge support from the Schermer Family Trust and the Fibus Family
   Foundation.
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NR 69
TC 13
Z9 13
U1 2
U2 37
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0300-8428
EI 1435-1803
J9 BASIC RES CARDIOL
JI Basic Res. Cardiol.
PD DEC
PY 2022
VL 117
IS 1
AR 3
DI 10.1007/s00395-021-00908-1
PG 15
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA YI0FP
UT WOS:000743533600001
PM 35039940
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Cordero-Herrera, I
   Guimaraes, DD
   Moretti, C
   Zhuge, ZB
   Han, HR
   Haworth, SM
   Gonzalez, AEU
   Andersson, DC
   Weitzberg, E
   Lundberg, JO
   Carlström, M
AF Cordero-Herrera, Isabel
   Guimaraes, Drielle D.
   Moretti, Chiara
   Zhuge, Zhengbing
   Han, Huirong
   Haworth, Sarah McCann
   Gonzalez, Arturo Eduardo Uribe
   Andersson, Daniel C.
   Weitzberg, Eddie
   Lundberg, Jon O.
   Carlstrom, Mattias
TI Head-to-head comparison of inorganic nitrate and metformin in a mouse
   model of cardiometabolic disease
SO NITRIC OXIDE-BIOLOGY AND CHEMISTRY
LA English
DT Article
ID TYPE-2 DIABETES-MELLITUS; BLOOD-PRESSURE; OXIDATIVE STRESS; DIETARY
   NITRATE; NITRIC-OXIDE; METABOLISM; MECHANISMS; FRUIT; MICE; NO
AB Background/Purpose: Unhealthy dietary habits contribute to the increasing incidence of metabolic syndrome and type 2 diabetes (T2D), which is accompanied by oxidative stress, compromised nitric oxide (NO) bioavailability and increased cardiovascular risk. Apart from lifestyle changes, biguanides such as metformin are the first-line pharmacological treatment for T2D. Favourable cardiometabolic effects have been demonstrated following dietary nitrate supplementation to boost the nitrate-nitrite-NO pathway. Here we aim to compare the therapeutic value of inorganic nitrate and metformin alone and their combination in a model of cardiometabolic disease.
   Experimental approach: Mice were fed control or high fat diet (HFD) for 7 weeks in combination with the NO synthase (NOS) inhibitor L-NAME to induce metabolic syndrome. Simultaneously, the mice were treated with vehicle, inorganic nitrate, metformin or a combination of nitrate and metformin in (drinking water). Cardiometabolic functions were assessed in vivo and tissues were collected/processed for analyses.
   Key results: HFD + L-NAME was associated with cardiometabolic dysfunction, compared with controls, as evident from elevated blood pressure, endothelial dysfunction, impaired insulin sensitivity and compromised glucose clearance as well as liver steatosis. Both nitrate and metformin improved insulin/glucose homeostasis, whereas only nitrate had favourable effects on cardiovascular function and steatosis. Mechanistically, metformin and nitrate improved AMPK signalling, whereas only nitrate attenuated oxidative stress. Combination of nitrate and metformin reduced HbA1c and trended to further increase AMPK activation.
   Conclusion/Implications: Nitrate and metformin had equipotent metabolic effects, while nitrate was superior regarding protection against cardiovascular dysfunction and liver steatosis. If reproduced in future clinical trials, these findings may have implications for novel nutrition-based strategies against metabolic syndrome, T2D and associated complications.
C1 [Cordero-Herrera, Isabel; Guimaraes, Drielle D.; Moretti, Chiara; Zhuge, Zhengbing; Han, Huirong; Haworth, Sarah McCann; Gonzalez, Arturo Eduardo Uribe; Andersson, Daniel C.; Weitzberg, Eddie; Lundberg, Jon O.; Carlstrom, Mattias] Karolinska Inst, Dept Physiol & Pharmacol, Stockholm, Sweden.
   [Andersson, Daniel C.] Karolinska Univ Hosp, Sect Heart Failure Arrhythmia & GUCH, Heart & Vasc Theme, Stockholm, Sweden.
   [Weitzberg, Eddie] Karolinska Univ Hosp, Dept Perioperat Med & Intens Care, Stockholm, Sweden.
C3 Karolinska Institutet; Karolinska Institutet; Karolinska University
   Hospital; Karolinska Institutet; Karolinska University Hospital
RP Lundberg, JO; Carlström, M (corresponding author), Karolinska Inst, Biomedicum, Dept Physiol & Pharmacol, 5B, S-17165 Solna, Sweden.
EM jon.lundberg@ki.se; mattias.carlstrom@ki.se
RI Han, Huirong/JXM-0776-2024; zhuge, zhengbing/E-8210-2017; Carlstrom,
   Mattias/E-7350-2015; Andersson, Daniel/AAE-9968-2019
OI Moretti, Chiara/0000-0002-0434-0278; McCann Haworth,
   Sarah/0000-0002-4299-5486; zhuge, zhengbing/0000-0002-6002-6670;
   Carlstrom, Mattias/0000-0001-9923-8729; Lundberg,
   Jon/0000-0002-0174-5210; Andersson, Daniel/0000-0003-4548-702X
FU Novo Nordisk postdoctoral fellowship [2-4078/2014]; Karolinska
   Institutet; Swedish Research Council [2016-01381]; Swedish Heart-Lung
   Foundation [20170124, 20180568]; NovoNordisk [0055026]; EFSD/Lilly
   European Diabetes Research Programme (2018) [97012]; Research Funds from
   Karolinska Institutet, Stockholm, Sweden [2-560/2015]; KID funding from
   the Karolinska Institutet, Stockholm, Sweden [2-3707/2013, 2-1930/2016];
   Swedish Heart-Lung Foundation [20180568, 20180568] Funding Source:
   Swedish Heart-Lung Foundation
FX We thank Carina Nihlen, Annika Olsson, Margareta Stensdotter (Karolinska
   Institutet, Stockholm, Sweden) for their technical assistance. ICH is
   supported by a Novo Nordisk postdoctoral fellowship (2-4078/2014) run in
   partnership with Karolinska Institutet. This work was supported by
   grants from the Swedish Research Council (2016-01381), the Swedish
   Heart-Lung Foundation (20170124, 20180568), NovoNordisk (2019#0055026),
   and by EFSD/Lilly European Diabetes Research Programme (2018#97012), as
   well as Research Funds (2-560/2015) and KID funding (2-3707/2013 &
   2-1930/2016) from the Karolinska Institutet, Stockholm, Sweden.
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NR 38
TC 19
Z9 23
U1 0
U2 4
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 1089-8603
EI 1089-8611
J9 NITRIC OXIDE-BIOL CH
JI Nitric Oxide-Biol. Chem.
PD APR 1
PY 2020
VL 97
BP 48
EP 56
DI 10.1016/j.niox.2020.01.013
PG 9
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA KS7QM
UT WOS:000518501200007
PM 32032718
OA hybrid
DA 2025-06-11
ER

PT J
AU Durak, A
   Olgar, Y
   Tuncay, E
   Karaomerlioglu, I
   Mutlu, GK
   Inan, EA
   Altan, VM
   Turan, B
AF Durak, Aysegul
   Olgar, Yusuf
   Tuncay, Erkan
   Karaomerlioglu, Irem
   Mutlu, Gizem Kayki
   Inan, Ebru Arioglu
   Altan, Vecdi Melih
   Turan, Belma
TI Onset of decreased heart work is correlated with increased heart rate
   and shortened QT interval in high-carbohydrate fed overweight rats
SO CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
LA English
DT Article; Proceedings Paper
CT 3rd European-Section Meeting of the
   International-Academy-of-Cardiovascular-Sciences
CY OCT 01-04, 2016
CL Marseille, FRANCE
SP Int Acad Cardiovascular Sci, European Sect
DE heart work; electrocardiogram; insulin resistance; metabolic syndrome;
   paraoxonase; arylesterase; oxidative stress
ID VENTRICULAR DIASTOLIC DYSFUNCTION; METABOLIC-SYNDROME; OXIDATIVE STRESS;
   INSULIN-RESISTANCE; CARDIOVASCULAR-DISEASE; ACCUMULATION; FAT;
   ANTIOXIDANTS; MODEL; DIET
AB Mechanical activity of the heart is adversely affected in metabolic syndrome (MetS) characterized by increased body mass and marked insulin resistance. Herein, we examined the effects of high carbohydrate intake on cardiac function abnormalities by evaluating in situ heart work, heart rate, and electrocardiograms (ECGs) in rats. MetS was induced in male Wistar rats by adding 32% sucrose to drinking water for 22-24 weeks and was confirmed by insulin resistance, increased body weight, increased blood glucose and serum insulin, and increased systolic and diastolic blood pressures in addition to significant loss of left ventricular integrity and increased connective tissue around myofibrils. Analysis of in situ ECG recordings showed a markedly shortened QT interval and decreased QRS amplitude with increased heart rate. We also observed increased oxidative stress and decreased antioxidant defense characterized by decreases in serum total thiol level and attenuated paraoxonase and arylesterase activities. Our data indicate that increased heart rate and a shortened QT interval concomitant with higher left ventricular developed pressure in response to 13-adrenoreceptor stimulation as a result of less cyclic AMP release could be regarded as a natural compensation mechanism in overweight rats with MetS. In addition to the persistent insulin resistance and obesity associated with MetS, one should consider the decreased heart work, increased heart rate, and shortened QT interval associated with high carbohydrate intake, which may have more deleterious effects on the mammalian heart.
C1 [Durak, Aysegul; Olgar, Yusuf; Tuncay, Erkan; Turan, Belma] Ankara Univ, Dept Biophys, Fac Med, Ankara, Turkey.
   [Karaomerlioglu, Irem; Mutlu, Gizem Kayki; Inan, Ebru Arioglu; Altan, Vecdi Melih] Ankara Univ, Dept Pharmacol, Fac Pharm, Ankara, Turkey.
C3 Ankara University; Ankara University
RP Turan, B (corresponding author), Ankara Univ, Dept Biophys, Fac Med, Ankara, Turkey.
EM belma.turan@medicine.ankara.edu.tr
RI olğar, yusuf/I-8960-2016; Kayki Mutlu, Gizem/ABC-4807-2021; Altan,
   Vecdi/AAQ-8776-2020; TUNCAY, ERKAN/AAG-8065-2020; durak,
   aysegul/AAA-7647-2022; TURAN, Belma/AAG-8084-2020
OI TUNCAY, ERKAN/0000-0002-6675-2534; OLGAR, YUSUF/0000-0002-3226-7450;
   TURAN, Belma/0000-0003-2583-9294
FU TUBITAK [SBAG-214S254]
FX This study was supported by TUBITAK SBAG-214S254.
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NR 59
TC 16
Z9 16
U1 0
U2 14
PU CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS
PI OTTAWA
PA 65 AURIGA DR, SUITE 203, OTTAWA, ON K2E 7W6, CANADA
SN 0008-4212
EI 1205-7541
J9 CAN J PHYSIOL PHARM
JI Can. J. Physiol. Pharmacol.
PD NOV
PY 2017
VL 95
IS 11
SI SI
BP 1335
EP 1342
DI 10.1139/cjpp-2017-0054
PG 8
WC Pharmacology & Pharmacy; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Pharmacology & Pharmacy; Physiology
GA FK8AN
UT WOS:000413729400004
PM 28758412
DA 2025-06-11
ER

PT J
AU Yakut, ZAÇ
   Bakar, E
   Sanal, F
   Çevik, D
   Karadag, ÇH
   Güzelmeriç, E
AF Yakut, Zatiye Ayca Cevikelli
   Bakar, Elvan
   Sanal, Filiz
   Cevik, Dicle
   Karadag, cetin Hakan
   Guzelmeric, Etil
TI Cornus mas ameliorates AlCl3-induced Alzheimer's
   disease in rats with metabolic syndrome by regulating inflammation and
   oxidative stress
SO NUTRITIONAL NEUROSCIENCE
LA English
DT Article; Early Access
DE Cornus mas; metabolic syndrome; Alzheimer's disease;
   aluminum; oxidative stress; inflammation; cognitive impairment;
   acetylcholinesterase
ID COGNITIVE DYSFUNCTION; ALUMINUM; L.; ACETYLCHOLINESTERASE; EPIDEMIOLOGY;
   HYPERTENSION; IMPAIRMENT; BRAIN; MODEL
AB Objectives:Alzheimer's disease (AD) results from different risk variables, such as metabolic syndrome (MetS) and environmental factors. The benefits of Cornus mas L. on diabetes are well-known. However, the impacts of C. mas fruits on AD or MetS-related cognitive dysfunction have not yet been studied. We evaluated the impact of C. mas fruit (80% ethanol) extract in an animal model of MetS and AD.Methods:Male Spraque-Dawley rats were administered a high-fat, high-sugar diet for 105 days alone or with an AlCl3 intraperitoneal injection for the last 60 days. C. mas fruit extract (400, 700, and 1000 mg/kg peroral) was administered for 60 days. After conducting behavioral tests and measuring blood pressure, hippocampal tissues and serum samples were obtained. The phytochemical analyses were conducted on C. mas fruit extract.Results:C. mas alleviated MetS by reducing blood glucose, total cholesterol, and systolic blood pressure levels. Behavioral tests demonstrated that C. mas improves AlCl3-related cognitive decline in rats with MetS, which was supported by the neuroprotective effect of C. mas in histological analysis. C. mas dose-dependently reduced amyloid-beta, malondialdehyde levels, acetylcholinesterase activity in the hippocampus, proinflammatory cytokines in serum, and elevated glutathione levels in the hippocampus. Phytochemical analyses revealed that C. mas fruit contains loganic acid, cornuside, and anthocyanins.Discussion:C. mas fruit extract in every three doses given could improve cognitive decline due to MetS and AlCl3 through alleviation of MetS, oxidative stress and inflammation, prevention of amyloid deposition, and increased cholinergic transmission.
C1 [Yakut, Zatiye Ayca Cevikelli] Trakya Univ, Fac Pharm, Dept Pharmacol, Edirne, Turkiye.
   [Bakar, Elvan] Trakya Univ, Fac Pharm, Dept Basic Pharmaceut Sci, Edirne, Turkiye.
   [Sanal, Filiz] Trakya Univ, Fac Sci, Dept Biol, Edirne, Turkiye.
   [Cevik, Dicle] Trakya Univ, Fac Pharm, Dept Pharmacognosy, Edirne, Turkiye.
   [Karadag, cetin Hakan] Trakya Univ, Sch Med, Dept Med Pharmacol, Edirne, Turkiye.
   [Guzelmeric, Etil] Yeditepe Univ, Fac Pharm, Dept Pharmacognosy, Istanbul, Turkiye.
C3 Trakya University; Trakya University; Trakya University; Trakya
   University; Trakya University; Yeditepe University
RP Yakut, ZAÇ (corresponding author), Trakya Univ, Fac Pharm, Dept Pharmacol, Edirne, Turkiye.
EM zaycacevikelli@trakya.edu.tr
RI Guzelmeric, Etil/ABB-7084-2021; Sanal, Filiz/O-9428-2019; Yakut,
   Zatiye/AAF-7800-2021; BAKAR, Elvan/AAE-9247-2022; Cevik,
   Dicle/P-6867-2019; Karadag, Cetin Hakan/H-4899-2013
OI Karadag, Cetin Hakan/0000-0002-4763-986X
FU Trakya University Scientific Research Project Fund [2021/113]
FX This study was supported by Trakya University Scientific Research
   Project Fund with the grant number 2021/113.
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NR 73
TC 0
Z9 0
U1 3
U2 3
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1028-415X
EI 1476-8305
J9 NUTR NEUROSCI
JI Nutr. Neurosci.
PD 2025 FEB 14
PY 2025
DI 10.1080/1028415X.2025.2460384
EA FEB 2025
PG 21
WC Neurosciences; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Nutrition & Dietetics
GA W7N5S
UT WOS:001420397300001
PM 39946185
DA 2025-06-11
ER

PT J
AU Kainuma, M
   Fujimoto, M
   Sekiya, N
   Tsuneyama, K
   Cheng, C
   Takano, Y
   Terasawa, K
   Shimada, Y
AF Kainuma, Mosaburo
   Fujimoto, Makoto
   Sekiya, Nobuyasu
   Tsuneyama, Koichi
   Cheng, Chunmei
   Takano, Yasuo
   Terasawa, Katsutoshi
   Shimada, Yutaka
TI Cholesterol-fed rabbit as a unique model of nonalcoholic, nonobese,
   non-insulin-resistant fatty liver disease with characteristic fibrosis
SO JOURNAL OF GASTROENTEROLOGY
LA English
DT Article
DE nonalcoholic fatty liver disease; hepatic stellate cell; hyperlipidemia;
   oxidative stress; adipocyte differentiation-related protein
ID STELLATE CELL ACTIVATION; OXIDATIVE DNA-DAMAGE; GROWTH-FACTOR-BETA;
   LIPID-PEROXIDATION; METABOLIC SYNDROME; STEATOHEPATITIS; ASSOCIATION;
   STRESS; ATHEROSCLEROSIS; FIBROGENESIS
AB Background. The number of patients suffering from metabolic syndrome is increasing rapidly. Metabolic syndrome causes severe pathological changes in various organs, including the liver, and its main phenotype is nonalcoholic fatty liver disease (NAFLD). NAFLD has a broad spectrum ranging from simple fatty change to severe steatohepatitis with marked fibrosis. Recently, several experimental animal models for NAFLD have been proposed. However, most were established by rather artificial conditions such as genetic alteration. In the present study, we tried to establish a unique animal model mimicking some of the physiopathological features of NAFLD using high-cholesterol-fed rabbits. Methods. Male rabbits fed with standard rabbit food containing 1% cholesterol for 8 weeks and 12 weeks were compared to controls (six rabbits/group). The weight of food was strictly restricted to 100 degrees Ceg/rabbit per day. Results. Body weights and fasting plasma insulin levels showed no significant differences among the groups. In contrast, characteristic fine fibrosis was extended from perivenular to pericellular areas, and microvesicular fatty change with ballooning degeneration was observed in perivenular areas in livers of the cholesterol-fed rabbits. Increase of serum cholesterol level, activation of hepatic stellate cells, and exposure to oxidative stress were also recognized. Conclusions. Cholesterol-fed rabbits share several physiopathological features of NAFLD. Because this model did not show insulin resistance or obesity, it may be useful for elucidating the mechanism of NAFLD related mainly to hyperlipidemia.
C1 Toyama Univ, Fac Med, Dept Japanese Oriental Med, Toyama 9300194, Japan.
   Toyama Univ, Fac Med, Dept Pathol 1, Toyama 930, Japan.
   Chiba Univ, Grad Sch Med, Dept Frontier Japanese Oriental Med, Chiba, Japan.
   Toyama Univ, Century COE Program 21, Toyama 930, Japan.
   Univ Calif Davis, Davis, CA 95616 USA.
   Chiba Univ, Grad Sch Med, Dept Japanese Oriental Med, Chiba, Japan.
C3 University of Toyama; University of Toyama; Chiba University; University
   of Toyama; University of California System; University of California
   Davis; Chiba University
RP Shimada, Y (corresponding author), Toyama Univ, Fac Med, Dept Japanese Oriental Med, 2630 Sugitani, Toyama 9300194, Japan.
OI Tsuneyama, Koichi/0000-0002-0670-9868
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NR 39
TC 82
Z9 97
U1 0
U2 7
PU SPRINGER JAPAN KK
PI TOKYO
PA SHIROYAMA TRUST TOWER 5F, 4-3-1 TORANOMON, MINATO-KU, TOKYO, 105-6005,
   JAPAN
SN 0944-1174
EI 1435-5922
J9 J GASTROENTEROL
JI J. Gastroenterol.
PD OCT
PY 2006
VL 41
IS 10
BP 971
EP 980
DI 10.1007/s00535-006-1883-1
PG 10
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA 104HG
UT WOS:000241948900005
PM 17096066
DA 2025-06-11
ER

PT J
AU Orsoni, A
   Thérond, P
   Tan, R
   Giral, P
   Robillard, P
   Kontush, A
   Meikle, PJ
   Chapman, MJ
AF Orsoni, Alexina
   Therond, Patrice
   Tan, Ricardo
   Giral, Philippe
   Robillard, Paul
   Kontush, Anatol
   Meikle, Peter J.
   Chapman, M. John
TI Statin action enriches HDL3 in polyunsaturated phospholipids and
   plasmalogens and reduces LDL-derived phospholipid hydroperoxides in
   atherogenic mixed dyslipidemia
SO JOURNAL OF LIPID RESEARCH
LA English
DT Article
DE antioxidative activity; low density lipoprotein; high density
   lipoprotein 3; lipidomics; metabolic syndrome disease; pitavastatin;
   oxidative stress; phospholipid hydroxides
ID HIGH-DENSITY-LIPOPROTEIN; CHOLESTERYL ESTER TRANSFER; ELEVATED OXIDATIVE
   STRESS; CORONARY-ARTERY-DISEASE; ANTI-APOPTOTIC ACTIVITY;
   CARDIOVASCULAR-DISEASE; OXIDIZED PHOSPHOLIPIDS; METABOLIC SYNDROME;
   ANTIOXIDATIVE ACTIVITY; LIPID HYDROPEROXIDES
AB Atherogenic mixed dyslipidemia associates with oxidative stress and defective HDL antioxidative function in metabolic syndrome (MetS). The impact of statin treatment on the capacity of HDL to inactivate LDL-derived, redox-active phospholipid hydroperoxides (PCOOHs) in MetS is indeterminate. Insulin-resistant, hypertriglyceridemic, hypertensive, obese males were treated with pitavastatin (4 mg/day) for 180 days, resulting in marked reduction in plasma TGs (-41%) and LDL-cholesterol (-38%), with minor effects on HDL-cholesterol and apoAI. Native plasma LDL (baseline vs. 180 days) was oxidized by aqueous free radicals under mild conditions in vitro either alone or in the presence of the corresponding pre- or poststatin HDL2 or HDL3 at authentic plasma mass ratios. Lipidomic analyses revealed that statin treatment i) reduced the content of oxidizable polyunsaturated phosphatidylcholine (PUPC) species containing DHA and linoleic acid in LDL; ii) preferentially increased the content of PUPC species containing arachidonic acid (AA) in small, dense HDL3; iii) induced significant elevation in the content of phosphatidylcholine and phosphatidylethanolamine (PE) plasmalogens containing AA and DHA in HDL3; and iv) induced formation of HDL3 particles with increased capacity to inactivate PCOOH with formation of redox-inactive phospholipid hydroxide. Statin action attenuated LDL oxidability Concomitantly, the capacity of HDL3 to inactivate redox-active PCOOH was enhanced relative to HDL2, consistent with preferential enrichment of PE plasmalogens and PUPC in HDL3.
C1 [Orsoni, Alexina; Therond, Patrice; Chapman, M. John] Bicetre Univ Hosp, APHP, HUPS, Clin Biochem Serv, Le Kremlin Bicetre, France.
   [Therond, Patrice] Univ Paris Sud, Lip Sys Dept, Atherosclerosis Cholesterol Homeostasis & Macroph, Chatenay Malabry, France.
   [Therond, Patrice] Paris Saclay Univ, Chatenay Malabry, France.
   [Tan, Ricardo; Meikle, Peter J.] Baker IDI Heart & Diabet Inst, Melbourne, Vic, Australia.
   [Giral, Philippe; Chapman, M. John] Pitie Salpetriere Univ Hop, Serv Endocrinol Metab & Cardiovasc Dis Prevent, Paris, France.
   [Robillard, Paul; Chapman, M. John] INSERM, UMR S939, Dyslipidemia & Atherosclerosis, Paris, France.
   [Robillard, Paul; Kontush, Anatol; Chapman, M. John] Univ Paris 06, Pitie Salpetriere Univ Hosp, Paris, France.
   [Kontush, Anatol] INSERM, UMR S1166, Paris, France.
C3 Assistance Publique Hopitaux Paris (APHP); Hopital Universitaire
   Ambroise-Pare - APHP; Hopital Universitaire Bicetre - APHP; Universite
   Paris Saclay; Universite Paris Saclay; Baker Heart and Diabetes
   Institute; Assistance Publique Hopitaux Paris (APHP); Sorbonne
   Universite; Institut National de la Sante et de la Recherche Medicale
   (Inserm); Assistance Publique Hopitaux Paris (APHP); Hopital
   Universitaire Pitie-Salpetriere - APHP; Sorbonne Universite; Sorbonne
   Universite; Institut National de la Sante et de la Recherche Medicale
   (Inserm)
RP Chapman, MJ (corresponding author), Bicetre Univ Hosp, APHP, HUPS, Clin Biochem Serv, Le Kremlin Bicetre, France.; Chapman, MJ (corresponding author), Pitie Salpetriere Univ Hop, Serv Endocrinol Metab & Cardiovasc Dis Prevent, Paris, France.; Chapman, MJ (corresponding author), INSERM, UMR S939, Dyslipidemia & Atherosclerosis, Paris, France.; Chapman, MJ (corresponding author), Univ Paris 06, Pitie Salpetriere Univ Hosp, Paris, France.
EM john.chapman@upmc.fr
RI chapman, john/Y-2742-2019; Kontush, Anatol/J-2198-2016; Meikle,
   Peter/B-4023-2009; ORSONI, Alexina/C-6740-2009
OI ORSONI, Alexina/0000-0003-4250-6280; Kontush,
   Anatol/0000-0002-9008-7335; Meikle, Peter/0000-0002-2593-4665; THEROND,
   Patrice/0000-0002-7655-2229
FU National Health and Medical Research Council of Australia (NHMRC);
   Operational Infrastructure Support (OIS) Program of the State Government
   of Victoria, Australia; NHMRC
FX The authors are indebted to Kowa Research Europe for the award of a
   Clinical Research Grant to support all aspects of the CAPITAIN study and
   lipidomic analyses (ClinicalTrials.gov, #NCT01595828), and to Institut
   National de la Sante et de la Recherche Medicale, the Nouvelle Societe
   Franaise d'Atherosclerose, and the Association for Research on
   Lipoproteins and Atherogenesis (ARLA) for additional support. A. Orsoni
   gratefully acknowledges the award of a postdoctoral fellowship from
   ARLA. This work was equally supported by funding from the National
   Health and Medical Research Council of Australia (NHMRC), the
   Operational Infrastructure Support (OIS) Program of the State Government
   of Victoria, Australia. P. J. Meikle is supported by an NHMRC Senior
   Research Fellowship. The content of this manuscript is solely the
   responsibility of the authors and does not necessarily represent the
   official views of the aforementioned funding bodies.
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NR 61
TC 29
Z9 30
U1 1
U2 14
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0022-2275
EI 1539-7262
J9 J LIPID RES
JI J. Lipid Res.
PD NOV
PY 2016
VL 57
IS 11
BP 2073
EP 2087
DI 10.1194/jlr.P068585
PG 15
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA EB3AB
UT WOS:000387232600011
PM 27581680
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Marková, I
   Malínská, H
   Hüttl, M
   Miklánková, D
   Oliyarnyk, O
   Poruba, M
   Rácová, Z
   Kazdová, L
   Vecera, R
AF Markova, Irena
   Malinska, Hana
   Huttl, Martina
   Miklankova, Denisa
   Oliyarnyk, Olena
   Poruba, Martin
   Racova, Zuzana
   Kazdova, Ludmila
   Vecera, Rostislav
TI The Combination of Atorvastatin With Silymarin Enhances Hypolipidemic,
   Antioxidant and Anti-Inflammatory Effects in a Rat Model of Metabolic
   Syndrome
SO PHYSIOLOGICAL RESEARCH
LA English
DT Article
DE Atorvastatin; Silymarin; Metabolic syndrome; Lipids; Oxidative stress
ID INSULIN-RESISTANCE; OXIDATIVE STRESS; STATIN USE; LIVER; DIET;
   BIOAVAILABILITY; INFLAMMATION; CHOLESTEROL; HOMEOSTASIS; INSIGHTS
AB Hypolipidemic and cardioprotective effects of statins can be associated with the development of myopathies and new-onset type 2 diabetes. These adverse effects may be related to increased oxidative stress. The plant extract silymarin (SM) is known for its antioxidant and anti-inflammatory actions. We tested the hypothesis that the combination of atorvastatin (ATV) with SM could improve therapy efficacy and eliminate some negative effects of statin on hypertriglyceridemia-induced metabolic disorders. Hereditary hypertriglyceridemic rats were fed a standard diet for four weeks without supplementation; supplemented with ATV (5 mg/kg b. wt./day) or a combination of ATV with 1 % micronized SM (ATV+SM). ATV treatment elevated plasma levels of HDL-cholesterol (p<0.01), glucose and insulin and decreased triglycerides (p<0.001). The combination of ATV+SM led to a significant reduction in insulin, an improvement of glucose tolerance, and the hypolipidemic effect was enhanced compared to ATV alone. Furthermore, ATV supplementation increased skeletal muscle triglycerides but its combination with SM decreased triglycerides accumulation in the muscle (p<0.05) and the liver (p<0.01). In the liver, ATV+SM treatment increased the activities of antioxidant enzymes, glutathione and reduced lipid peroxidation (p<0.001). The combined administration of ATV with SM potentiated the hypolipidemic effect, reduced ectopic lipid accumulation, improved glucose metabolism, and increased antioxidant and anti-inflammatory actions. Our results show that SM increased the effectiveness of statin therapy in a hypertriglyceridemic rat model of metabolic syndrome.Y
C1 [Markova, Irena; Malinska, Hana; Huttl, Martina; Miklankova, Denisa; Oliyarnyk, Olena; Kazdova, Ludmila] Inst Clin & Expt Med, Ctr Expt Med, Videnska 1958, Prague 14021 4, Czech Republic.
   [Poruba, Martin; Racova, Zuzana; Vecera, Rostislav] Palacky Univ Olomouc, Fac Med & Dent, Dept Pharmacol, Olomouc, Czech Republic.
C3 Institute for Clinical & Experimental Medicine (IKEM); Palacky
   University Olomouc
RP Marková, I (corresponding author), Inst Clin & Expt Med, Ctr Expt Med, Videnska 1958, Prague 14021 4, Czech Republic.
EM irena.markova@ikem.cz
RI Oliyarnyk, Olena/Q-6380-2019
OI Miklankova, Denisa/0000-0002-8771-9338; Markova,
   Irena/0000-0002-4331-7636; Racova, Zuzana/0000-0001-9478-9513
FU Czech Science Foundation GACR [17-08888-S]; Ministry of Health of the
   Czech Republic under the conceptual development of research
   organizations programme (Institute for Clinical and Experimental
   Medicine - IKEM) [IN 00023001]
FX The study was supported by the Czech Science Foundation GACR, project
   number 17-08888-S and by the Ministry of Health of the Czech Republic
   under the conceptual development of research organizations programme
   (Institute for Clinical and Experimental Medicine - IKEM, IN 00023001).
   We wish to thank Jan Pitha for his extensive help with reviewing the
   manuscript and David Hardekopf for his extensive help with correcting
   the text.
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NR 38
TC 9
Z9 9
U1 0
U2 9
PU ACAD SCIENCES CZECH REPUBLIC, INST PHYSIOLOGY
PI PRAGUE 4
PA VIDENSKA 1083, PRAGUE 4 142 20, CZECH REPUBLIC
SN 0862-8408
EI 1802-9973
J9 PHYSIOL RES
JI Physiol. Res.
PD FEB
PY 2021
VL 70
IS 1
BP 33
EP 43
DI 10.33549/physiolres.934587
PG 11
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA RA0ZD
UT WOS:000631146600004
PM 33453720
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Ferri, S
   Stefanini, B
   Minguzzi, M
   Leoni, S
   Capelli, R
   Secomandi, A
   Chen, RS
   Abbati, C
   Santangeli, E
   Mattarozzi, K
   Fabio, P
AF Ferri, Silvia
   Stefanini, Bernardo
   Minguzzi, Marta
   Leoni, Simona
   Capelli, Roberta
   Secomandi, Alice
   Chen, Rusi
   Abbati, Chiara
   Santangeli, Ernestina
   Mattarozzi, Katia
   Fabio, Piscaglia
TI Effects of COVID-19 Pandemic on Metabolic Status and Psychological
   Correlates of a Cohort of Italian NAFLD Outpatients
SO NUTRIENTS
LA English
DT Article
DE NAFLD; COVID-19; metabolic syndrome; psychological distress; behavioral
   approach
ID FATTY LIVER-DISEASE; PHYSICAL-ACTIVITY; MEDITERRANEAN DIET; DEPRESSION;
   ANXIETY
AB Simple Summary One out of four patients with NAFLD and metabolic syndrome is also affected by psychological distress. In this study, we evaluated the impact of a stressful contingency such as the COVID-19 lockdown on a cohort of Italian patients affected by NAFLD. Our data confirmed the association between psychological distress and NAFLD. They also showed how psychological suffering was associated with a worse efficacy of the behavioral therapeutic approach in patients with NAFLD. Non-alcoholic fatty liver disease (NAFLD) is a potentially progressive condition characterized by the presence of fat in more than 5% of hepatocytes, representing the hepatic expression of metabolic syndrome (MetS). A reduction of at least 5-7% in initial body weight improves the metabolic profile underlying NAFLD. The aim of our study was to evaluate the effects of the COVID-19 lockdown on a cohort of non-advanced NAFLD Italian outpatients. We identified 43 patients with 3 available time point visits in our center: first visit (T0) when behavioral indications aimed at controlling MetS were provided, a pre-COVID visit (T1) and a post-COVID visit (T2). During the lockdown, an online compilation of validated psychological tests (SRQ-20, EQ5D, SF-12 and STAI) and a specifically formulated questionnaire for NAFLD was presented to our cohort and completed by 14 consenting patients. Patients who had lost more than 5% of the initial weight at T1 (9 subjects, 21%) maintained the results even at T2, with an overall reduction in BMI and liver stiffness; patients who had not lost the desired weight at T1 (34 subjects, 79%) displayed a further increase in BMI and visceral adiposity at T2. Of interest is that patients in the latter group reported signs of psychological suffering. Our data demonstrated that the setting of good counseling was effective in controlling the metabolic disorder underlying NAFLD in our cohort of outpatients. Given the need for patients to play an active role in the behavioral therapy for NAFLD, we advocate that a multidisciplinary approach be adopted, including a psychological support to obtain the best results over time.
C1 [Ferri, Silvia; Leoni, Simona; Fabio, Piscaglia] IRCCS Azienda Osped Univ Bologna, Div Internal Med Hepatobiliary & Immunoallerg Dis, I-40138 Bologna, Italy.
   [Stefanini, Bernardo; Minguzzi, Marta; Capelli, Roberta; Secomandi, Alice; Chen, Rusi; Abbati, Chiara; Santangeli, Ernestina; Mattarozzi, Katia; Fabio, Piscaglia] Univ Bologna, Dept Med & Surg Sci, I-40126 Bologna, Italy.
C3 IRCCS Azienda Ospedaliero-Universitaria di Bologna; University of
   Bologna
RP Fabio, P (corresponding author), IRCCS Azienda Osped Univ Bologna, Div Internal Med Hepatobiliary & Immunoallerg Dis, I-40138 Bologna, Italy.; Fabio, P (corresponding author), Univ Bologna, Dept Med & Surg Sci, I-40126 Bologna, Italy.
EM fabio.piscaglia@unibo.it
RI Piscaglia, Fabio/AAC-6899-2022; Capelli, Roberta/KIG-6973-2024; Leoni,
   Simona/AAC-7157-2022; Stefanini, Bernardo/GWQ-5807-2022
OI Stefanini, Bernardo/0000-0003-3800-5678; Piscaglia,
   Fabio/0000-0001-8264-1845
CR Beusenberg M., A user's guide to the self reporting questionnaire (SRQ
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NR 33
TC 1
Z9 1
U1 0
U2 1
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD MAR
PY 2023
VL 15
IS 6
AR 1445
DI 10.3390/nu15061445
PG 14
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA A8UO7
UT WOS:000957816400001
PM 36986175
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Treviño, S
   Aguilar-Alonso, P
   Hernandez, JAF
   Brambila, E
   Guevara, J
   Flores, G
   Lopez-Lopez, G
   Muñoz-Arenas, G
   Morales-Medina, JC
   Toxqui, V
   Venegas, B
   Diaz, A
AF Trevino, Samuel
   Aguilar-Alonso, Patricia
   Flores Hernandez, Jose Angel
   Brambila, Eduardo
   Guevara, Jorge
   Flores, Gonzalo
   Lopez-Lopez, Gustavo
   Munoz-Arenas, Guadalupe
   Morales-Medina, Julio Cesar
   Toxqui, Veronica
   Venegas, Berenice
   Diaz, Alfonso
TI A high calorie diet causes memory loss, metabolic syndrome and oxidative
   stress into hippocampus and temporal cortex of rats
SO SYNAPSE
LA English
DT Article
DE metabolic syndrome; high-caloric diet; astrocytes; reactive oxygen
   species; neurodegeneration; hippocampus
ID BLOOD-BRAIN-BARRIER; ALZHEIMERS-DISEASE; SYNAPTIC PLASTICITY;
   DIABETES-MELLITUS; FAT DIET; INDUCED NEUROTOXICITY; COGNITIVE
   IMPAIRMENT; INSULIN-RESISTANCE; INDUCED OBESITY; NITRIC-OXIDE
AB A high calorie intake can induce the appearance of the metabolic syndrome (MS), which is a serious public health problem because it affects glucose levels and triglycerides in the blood. Recently, it has been suggested that MS can cause complications in the brain, since chronic hyperglycemia and insulin resistance are risk factors for triggering neuronal death by inducing a state of oxidative stress and inflammatory response that affect cognitive processes. This process, however, is not clear. In this study, we evaluated the effect of the consumption of a high-calorie diet (HCD) on both neurodegeneration and spatial memory impairment in rats. Our results demonstrated that HCD (90 day consumption) induces an alteration of the main energy metabolism markers, indicating the development of MS in rats. Moreover, an impairment of spatial memory was observed. Subsequently, the brains of these animals showed activation of an inflammatory response (increase in reactive astrocytes and interleukin1- as well as tumor necrosis factor-) and oxidative stress (reactive oxygen species and lipid peroxidation), causing a reduction in the number of neurons in the temporal cortex and hippocampus. Altogether, these results suggest that a HCD promotes the development of MS and contributes to the development of a neurodegenerative process and cognitive failure. In this regard, it is important to understand the relationship between MS and neuronal damage in order to prevent the onset of neurodegenerative disorders. Synapse 69:421-433, 2015. (c) 2015 Wiley Periodicals, Inc.
C1 [Trevino, Samuel; Flores Hernandez, Jose Angel; Brambila, Eduardo; Toxqui, Veronica] Benemerita Univ Autonoma Puebla, Fac Ciencias Quim, Dept Anal Clin, Puebla 72570, Mexico.
   [Aguilar-Alonso, Patricia] Benemerita Univ Autonoma Puebla, Fac Ciencias Quim, Dept Bioquim, Puebla 72570, Mexico.
   [Guevara, Jorge] Univ Nacl Autonoma Mexico, Fac Med, Dept Bioquim, Mexico City 04510, DF, Mexico.
   [Flores, Gonzalo] Benemerita Univ Autonoma Puebla, Inst Fisiol, Lab Neuropsiquiatria, Puebla 72570, Mexico.
   [Lopez-Lopez, Gustavo; Munoz-Arenas, Guadalupe; Diaz, Alfonso] Benemerita Univ Autonoma Puebla, Fac Ciencias Quim, Dept Farm, Puebla 72570, Mexico.
   [Morales-Medina, Julio Cesar] Univ Autonoma Tlaxcala, Ctr Invest Reproducc Anim, CINVESTAV, Tlaxcala De Xicohtencatl, Mexico.
   [Toxqui, Veronica] INNN MVS, Lab Expt Enfermedades Neurodegenerat, Mexico City 14269, DF, Mexico.
   [Venegas, Berenice] Benemerita Univ Autonoma Puebla, Inst Ciencias, Lab Biol & Toxicol Reproducc, Puebla 72570, Mexico.
C3 Benemerita Universidad Autonoma de Puebla; Benemerita Universidad
   Autonoma de Puebla; Universidad Nacional Autonoma de Mexico; Benemerita
   Universidad Autonoma de Puebla; Benemerita Universidad Autonoma de
   Puebla; CINVESTAV - Centro de Investigacion y de Estudios Avanzados del
   Instituto Politecnico Nacional; Benemerita Universidad Autonoma de
   Puebla
RP Diaz, A (corresponding author), Univ Autonoma Puebla, Dept Farm, Puebla 72570, Mexico.
EM alfonso.diaz@correo.buap.mx
RI Hernández, José/JKI-8418-2023; Flores, Gonzalo/B-1807-2014; Venegas,
   Berenice/AAG-4048-2021; Morales-Medina, Julio Cesar/ABE-3920-2021
OI Flores, Gonzalo/0000-0002-4100-2104; Diaz, Alfonso/0000-0003-4092-6636;
   Trevino, Samuel/0000-0001-5679-1671; VENEGAS MENESES,
   BERENICE/0000-0001-9009-655X
FU CONACYT, National Research System of Mexico
FX Contract grant sponsor: CONACYT, National Research System of Mexico..
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NR 76
TC 69
Z9 74
U1 1
U2 42
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0887-4476
EI 1098-2396
J9 SYNAPSE
JI Synapse
PD SEP
PY 2015
VL 69
IS 9
BP 421
EP 433
DI 10.1002/syn.21832
PG 13
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA CN5AA
UT WOS:000358440500001
PM 26073877
DA 2025-06-11
ER

PT J
AU Vazzana, N
   Santilli, F
   Sestili, S
   Cuccurullo, C
   Davì, G
AF Vazzana, N.
   Santilli, F.
   Sestili, S.
   Cuccurullo, C.
   Davi, G.
TI Determinants of Increased Cardiovascular Disease in Obesity and
   Metabolic Syndrome
SO CURRENT MEDICINAL CHEMISTRY
LA English
DT Review
DE Adipokines; cardiovascular disease; inflammation; insulin resistance;
   metabolic syndrome; obesity; oxidative stress; platelet activation
ID MEAN PLATELET VOLUME; BODY-MASS INDEX; GLYCATION END-PRODUCTS;
   C-REACTIVE PROTEIN; CORONARY-ARTERY-DISEASE; OBSTRUCTIVE SLEEP-APNEA;
   LIFE-STYLE MODIFICATION; IN-VIVO FORMATION; SERUM AMYLOID-A;
   INSULIN-RESISTANCE
AB Obesity is associated with an increased mortality and morbidity for cardiovascular disease (CVD) and adipose tissue is recognised as an important player in obesity-mediated CVD. The diagnosis of the metabolic syndrome (MS) appears to identify substantial additional cardiovascular risk above and beyond the individual risk factors, even though the pathophysiology underlying this evidence is still unravelled.
   The inflammatory response related to fat accumulation may influence cardiovascular risk through its involvement not only in body weight homeostasis, but also in coagulation, fibrinolysis, endothelial dysfunction, insulin resistance (IR) and atherosclerosis. Moreover, there is evidence that oxidative stress may be a mechanistic link between several components of MS and CVD, through its role in inflammation and its ability to disrupt insulin-signaling. The cross-talk between impaired insulin-signaling and inflammatory pathways enhances both metabolic IR and endothelial dysfunction, which synergize to predispose to CVD.
   Persistent platelet hyperreactivity/activation emerges as the final pathway driven by intertwined interactions among IR, adipokine release, inflammation, dyslipidemia and oxidative stress and provides a pathophysiological explanation for the excess risk of atherothrombosis in this setting.
   Despite the availability of multiple interventions to counteract these metabolic changes, including appropriate diet, regular exercise, anti-obesity drugs and bariatric surgery, relative failure to control the incidence of MS and its complications reflects both the multifactorial nature of these diseases as well as the scarce compliance of patients to established strategies. Evaluation of the impact of these therapeutic strategies on the pathobiology of atherothrombosis, as discussed in this review, will translate into an optimized approach for cardiovascular prevention.
C1 [Vazzana, N.; Santilli, F.; Sestili, S.; Cuccurullo, C.; Davi, G.] Univ G dAnnunzio, Ctr Excellence Aging, I-66013 Chieti, Italy.
C3 G d'Annunzio University of Chieti-Pescara
RP Davì, G (corresponding author), Univ G dAnnunzio, Ctr Excellence Aging, Via Colle dellAra, I-66013 Chieti, Italy.
RI Santilli, Francesca/ABC-6243-2021; Davi, Giovanni/K-7659-2016
OI Davi, Giovanni/0000-0002-3044-0870; Santilli,
   Francesca/0000-0002-4593-905X
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NR 173
TC 54
Z9 61
U1 0
U2 11
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 0929-8673
EI 1875-533X
J9 CURR MED CHEM
JI Curr. Med. Chem.
PD DEC
PY 2011
VL 18
IS 34
BP 5267
EP 5280
DI 10.2174/092986711798184299
PG 14
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Pharmacology &
   Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
GA 883DH
UT WOS:000299612700008
PM 22087824
DA 2025-06-11
ER

PT J
AU Garbarino, S
   Guglielmi, O
   Puntoni, M
   Bragazzi, NL
   Magnavita, N
AF Garbarino, Sergio
   Guglielmi, Ottavia
   Puntoni, Matteo
   Bragazzi, Nicola Luigi
   Magnavita, Nicola
TI Sleep Quality among Police Officers: Implications and Insights from a
   Systematic Review and Meta-Analysis of the Literature
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Review
DE police; sleep; occupational health; meta-analysis; prevalence; public
   health; sleep deprivation; health promotion; sleep hygiene
ID METABOLIC SYNDROME; MENTAL-HEALTH; DURATION; WORK; ASSOCIATION;
   DISORDERS; STRESS; INDEX; SHIFT; RISK
AB Poor sleep is associated with bad health outcomes, worse wellbeing and decreases in performance, productivity and safety at work. Police officers are exposed to several risk factors including extended work schedules, shift work, occupational stress, dangerous and traumatic events and can, as such, develop sleep problems. The aim of the present study was to analyze the sleep quality among police officers. A systematic literature search, in PubMed/MEDLINE, PsycINFO, Scopus, ISI/Web of Science (WoS) and the Cochrane Library was conducted. Original articles, published in English, French, Italian, Spanish and Portuguese, the primary objective of which was the evaluation of the quality of sleep through the Pittsburgh Sleep Quality Index (PSQI) in Police Forces, were selected. From an initial sample of 1,149 studies, 13 articles were included in the meta-analysis (3,722 police officers). The pooled prevalence of bad sleep quality in police officers was 51% [95%CI 42-60%]. The pooled global score of the PSQI was 5.6 [95%CI 5.0-6.3], corresponding to a low average quality. At the meta-regressions, statistically significant associations could be found for work seniority (in terms of years of service) and being on shift. The poor quality of sleep in police officers could have negative consequences for workers' health and for the safety of third parts. The implementation of health and sleep hygiene promotion programs in police forces is strongly recommended.
C1 [Garbarino, Sergio; Guglielmi, Ottavia] Univ Genoa, Polyclin Hosp San Martino IRCCS, Dept Neurosci Rehabil Ophthalmol Genet & Maternal, I-16132 Genoa, Italy.
   [Puntoni, Matteo] EO Galliera Hosp, Clin Trial Off, I-16128 Genoa, Italy.
   [Bragazzi, Nicola Luigi] Univ Genoa, UNESCO Chair Anthropol Hlth Biosphere & Healing S, I-16132 Genoa, Italy.
   [Magnavita, Nicola] Univ Cattolica Sacro Cuore, Fdn Policlin Gemelli IRCCS, Dept Woman Child & Publ Hlth, I-00168 Rome, Italy.
C3 University of Genoa; Ente Ospedaliero Ospedali Galliera; University of
   Genoa; Catholic University of the Sacred Heart; IRCCS Policlinico
   Gemelli
RP Guglielmi, O (corresponding author), Univ Genoa, Polyclin Hosp San Martino IRCCS, Dept Neurosci Rehabil Ophthalmol Genet & Maternal, I-16132 Genoa, Italy.
EM sgarbarino.neuro@gmail.com; ottavia.guglielmi@gmail.com;
   matteo.puntoni@gmail.com; robertobragazzi@gmail.com;
   nicolamagnavita@gmail.com
RI Magnavita, Nicola/J-6074-2014; Puntoni, Matteo/J-5440-2016; Bragazzi,
   Nicola/G-1672-2011; Garbarino, Sergio/X-5368-2018
OI Puntoni, Matteo/0000-0002-7908-0626; Bragazzi,
   Nicola/0000-0001-8409-868X; Garbarino, Sergio/0000-0002-8508-552X
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NR 60
TC 61
Z9 65
U1 5
U2 27
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD MAR 1
PY 2019
VL 16
IS 5
AR 885
DI 10.3390/ijerph16050885
PG 15
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA HQ8HD
UT WOS:000462664200210
PM 30862044
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Arista-Ugalde, TL
   Santiago-Osorio, E
   Monroy-García, A
   Rosado-Pérez, J
   Aguiñiga-Sánchez, I
   Cadena-Iñiguez, J
   Gavia-García, G
   Mendoza-Núñez, VM
AF Laurita Arista-Ugalde, Taide
   Santiago-Osorio, Edelmiro
   Monroy-Garcia, Alberto
   Rosado-Perez, Juana
   Aguiniga-Sanchez, Itzen
   Cadena-Iniguez, Jorge
   Gavia-Garcia, Graciela
   Manuel Mendoza-Nunez, Victor
TI Antioxidant and Anti-Inflammatory Effect of the Consumption of Powdered
   Concentrate of Sechium edule var. nigrum spinosum in
   Mexican Older Adults with Metabolic Syndrome
SO ANTIOXIDANTS
LA English
DT Article
DE metabolic syndrome; oxidative stress; anti-inflammatory; Sechium edule;
   older adults
ID INTERLEUKIN-6; ASSOCIATION; CHOLESTEROL; LIPOGENESIS; ACTIVATION;
   TRANSPORT; ENZYMES
AB Metabolic syndrome (MetS) has a high prevalence in older adults and is a risk factor for cardiovascular diseases and complications of old age. It has also been related to oxidative stress (OxS) and chronic inflammation (CI) and their consequent alterations. Therefore, it is important to propose therapeutic alternatives such as the consumption of Sechium edule (Chayote), since hypoglycemic, hypotensive, and lipogenesis inhibitor properties are attributed to it. We carried out a study in 81 older adults (OA) with MetS to determine the effect of consumption of chayote powder concentrate (500 mg, three times a day) for six months, with a baseline measurement, at three and six months in an experimental group (EG) (n = 41) and a placebo group (PG) (n = 40), all with a diagnosis of MetS according to the criteria of National Adult Treatment Panel of the National Cholesterol Program III (NCEP/ATP III). Anthropometric, biochemical, OxS markers, and inflammation measurements were performed on all participants, basal, three, and six months after. A statistically significant decrease was found in the concentration of lipoperoxides (TBARS), 8-isoprostanes, 8-OHdG, oxidative stress score (OSS), HbA1c, blood pressure, and in the number of MetS diagnostic criteria, as well as an increase in total antioxidant status (TAS), antioxidant gap (GAP), superoxide dismutase (SOD), interleukin 10 (IL-10), and HDL-cholesterol in EG. The results suggest that the consumption of Sechium edule powder has a hypotensive, hypoglycemic, antioxidant, and anti-inflammatory effect in OA with MetS and reduced the percentage of patients with MetS.
C1 [Laurita Arista-Ugalde, Taide; Rosado-Perez, Juana; Gavia-Garcia, Graciela; Manuel Mendoza-Nunez, Victor] Univ Nacl Autonoma Mexico, Res Unit Gerontol, FES Zaragoza, Mexico City 09230, DF, Mexico.
   [Santiago-Osorio, Edelmiro] Univ Nacl Autonoma Mexico, Res Unit Cell Differentiat & Canc, Hematopoiesis & Leukemia Lab, FES Zaragoza, Mexico City 09230, DF, Mexico.
   [Monroy-Garcia, Alberto] Inst Mexicano Seguro Social, Med Res Unit Oncol Dis, Immunol & Canc Lab, CMN SXXI, Mexico City 06720, DF, Mexico.
   [Aguiniga-Sanchez, Itzen] Postgrad Coll, Campus San Luis Potosi,Iturbide 73 St, San Luis Potosi 78600, San Luis Potosi, Mexico.
   [Cadena-Iniguez, Jorge] Univ Nacl Autonoma Mexico, Sch Med, Dept Biomed Sci, FES Zaragoza, Mexico City 09230, DF, Mexico.
C3 Universidad Nacional Autonoma de Mexico; Universidad Nacional Autonoma
   de Mexico; Instituto Mexicano del Seguro Social; Universidad Nacional
   Autonoma de Mexico
RP Mendoza-Núñez, VM (corresponding author), Univ Nacl Autonoma Mexico, Res Unit Gerontol, FES Zaragoza, Mexico City 09230, DF, Mexico.
EM tdlarista@comunidad.unam.mx; edelmiro@unam.mx;
   albertomong13@comunidad.unam.mx; juanarosadoperez@comunidad.unam.mx;
   liberitzen@comunidad.unam.mx; jocadena@colpos.mx; ggg1501@hotmail.com;
   mendovic@unam.mx
RI Monroy-García, Alberto/AAW-7048-2021; Mendoza-Núñez, Víctor
   Manuel/AFL-2465-2022
OI Aguiniga-Sanchez, Itzen/0000-0003-1692-8287; Santiago-Osorio,
   Edelmiro/0000-0002-4876-0688; Mendoza-Nunez, Victor
   Manuel/0000-0002-9137-3405
FU General Directorate of Academic Personnel Affairs, National Autonomous
   University of Mexico (DGAPA); Secretariat of Science [PAPIIT IN215821];
   Technology and Innovation Project of Mexico City (SECITI)
   [SECITI/045/2018]; General Directorate of Academic Personnel Affairs,
   National Autonomous University of Mexico (UNAM)
FX Y This work was supported by grants from the General Directorate of
   Academic Personnel Affairs, National Autonomous University of Mexico
   (DGAPA and UNAM), the Secretariat of Science (PAPIIT IN215821), and the
   Technology and Innovation Project of Mexico City (SECITI)
   (SECITI/045/2018). Additionally, at "Posgrado en Ciencias Biologicas,
   UNAM".
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NR 40
TC 7
Z9 7
U1 3
U2 8
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD JUN
PY 2022
VL 11
IS 6
AR 1076
DI 10.3390/antiox11061076
PG 14
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA 2K2IZ
UT WOS:000816167700001
PM 35739973
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Bobe, G
   Cobb, TJ
   Leonard, SW
   Aponso, S
   Bahro, CB
   Koley, D
   Mah, E
   Bruno, RS
   Traber, MG
AF Bobe, Gerd
   Cobb, Tora J.
   Leonard, Scott W.
   Aponso, Savinda
   Bahro, Christopher B.
   Koley, Dipankar
   Mah, Eunice
   Bruno, Richard S.
   Traber, Maret G.
TI Increased static and decreased capacity oxidation-reduction potentials
   in plasma are predictive of metabolic syndrome
SO REDOX BIOLOGY
LA English
DT Article
DE Metabolic syndrome; Inflammation; Obesity; Dyslipidemia; Isoprostanes;
   Lipid peroxidation; Oxidation-reduction potential
ID MAJOR URINARY METABOLITE; STRESS; F-2-ISOPROSTANE; QUANTIFICATION;
   ASSOCIATION; PREVALENCE; ADULTS; ALPHA; RISK
AB Electric conductivity in plasma is the balance between oxidized and reduced molecules (static Oxidation-Reduction Potential, sORP) and the amount of readily oxidizable molecules (capacity ORP, cORP). Adults with metabolic syndrome (MetS) have increased inflammation, dyslipidemia and oxidative stress; therefore, participants with MetS were hypothesized to have higher plasma sORP and lower cORP than those measures in healthy adults. Heparin-anticoagulated plasma from healthy and age-and gender-matched individuals with MetS (BMI: 22.6 +/- 0.7 vs. 37.7 +/- 3.0 kg/m(2), respectively) was collected in the fasting state at 0, 24, 48, and 72 h during each of four separate interventions in a clinical trial. At baseline, plasma sORP was 12.4% higher (P=0.007), while cORP values were less than half (41.1%, P=0.001) in those with MetS compared with healthy participants. An sORP > 140 mV detected MetS with 90% sensitivity and 80% specificity, while a cORP < 0.50 mu C detected MetS with 80% sensitivity and 100% specificity. sORP and cORP values in participants with MetS compared with healthy adults were linked to differences in waist circumference and BMI; in plasma markers of dyslipidemia (triglycerides, HDL-cholesterol, and oxidized LDL-cholesterol) and inflammation (Creactive protein, IL-10); as well as with urinary markers of lipid peroxidation (e.g., 2,3-dinor-5,6-dihydro-8-iso-PGF2a; 2,3-dinor-8-iso-PGF2 alpha). Higher sORP values are a robust indicator of metabolic stress, while lower cORP values act as an indicator of decreased metabolic resilience.
C1 [Bobe, Gerd; Cobb, Tora J.; Leonard, Scott W.; Traber, Maret G.] Oregon State Univ, Linus Pauling Inst, 307 LPSC, Corvallis, OR 97331 USA.
   [Aponso, Savinda; Bahro, Christopher B.; Koley, Dipankar] Oregon State Univ, Dept Chem, Corvallis, OR 97331 USA.
   [Mah, Eunice] Biofortis Inc, Addison, IL USA.
   [Mah, Eunice; Bruno, Richard S.] Ohio State Univ, Human Nutr Program, Columbus, OH 43210 USA.
C3 Oregon State University; Oregon State University; University System of
   Ohio; Ohio State University
RP Traber, MG (corresponding author), Oregon State Univ, Linus Pauling Inst, 307 LPSC, Corvallis, OR 97331 USA.
EM maret.traber@oregonstate.edu
RI Bruno, Richard/K-1930-2012; Koley, Dipankar/A-3509-2015; Traber,
   Maret/ABI-2511-2020
OI Leonard, Scott/0000-0001-9967-7078; Traber, Maret/0000-0002-2892-4024;
   Bruno, Richard/0000-0002-6772-2038
FU DSM Nutrition; National Dairy Council; National Institutes of Health
   NIDDK [DK081761]; NCATS [UL1TR001070]
FX Support provided by DSM Nutrition, the National Dairy Council, the
   National Institutes of Health NIDDK (DK081761) and NCATS (UL1TR001070).
   The funders had no influence on the study design, implementation, data
   analysis, or interpretation regarding the conclusions of this study.
CR [Anonymous], ANAL CHEM 2 0
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NR 29
TC 23
Z9 26
U1 0
U2 7
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2213-2317
J9 REDOX BIOL
JI Redox Biol.
PD AUG
PY 2017
VL 12
BP 121
EP 128
DI 10.1016/j.redox.2017.02.010
PG 8
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA EX6CA
UT WOS:000403328700011
PM 28222379
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Nguyen, HD
   Kim, MS
AF Nguyen, Hai Duc
   Kim, Min-Sun
TI The Effects of a Mixture of Cadmium, Lead, and Mercury on Metabolic
   Syndrome and Its Components, as well as Cognitive Impairment: Genes,
   MicroRNAs, Transcription Factors, and Sponge Relationships
SO BIOLOGICAL TRACE ELEMENT RESEARCH
LA English
DT Article; Early Access
DE Heavy metals; Genes; miRNAs; miRNA sponges; Metabolic syndrome;
   Cognitive impairment
ID ALZHEIMERS-DISEASE; HEAVY-METALS; INSULIN-RESISTANCE; OXIDATIVE STRESS;
   APOLIPOPROTEIN-E; GROWTH-HORMONE; ADIPOSE-TISSUE; MOUSE MODEL; BLOOD
   LEAD; IGF-I
AB Converging evidence indicates heavy metal-induced genes, transcription factors (TFs), and microRNAs (miRNAs) are critical pathological components of metabolic syndrome (MetS) and cognitive impairment. Thus, our goals are to identify the interaction of mixed heavy metals (cadmium + lead + mercury) with genes, TFs, and miRNAs involved in MetS and its components, as well as cognitive impairment development. The most commonly retrieved genes for each disease were different, but essential biological pathways such as oxidative stress, altered lipoprotein metabolism, fluid shear stress and atherosclerosis, apoptosis, the IL-6 signaling pathway, and Alzheimer's disease were highlighted. The genes CASP3, BAX, BCL2, IL6, TNF, APOE, HMOX1, and IGF were found to be mutually affected by the heavy metal mixture studied, suggesting the importance of apoptosis, inflammation, lipid, heme, and glucose metabolism in MetS and cognitive impairment, as well as the potentiality of targeting these genes in prospective therapeutic intervention for these diseases. EGR2, ATF3, and NFE2L2 were noted as the most key TFs implicated in the etiology of MetS and its components, as well as cognitive impairment. We also found six miRNAs induced by studied heavy metals were the mutual miRNAs linked to MetS, its components, and cognitive impairment. In particular, we used miRNAsong to construct and verify a miRNA sponge sequence for these miRNAs. These sponges are promising molecules for the treatment of MetS and its components, as well as cognitive impairment.
C1 [Nguyen, Hai Duc; Kim, Min-Sun] Sunchon Natl Univ, Coll Pharm, Dept Pharm, Sunchon 57922, South Korea.
   [Nguyen, Hai Duc; Kim, Min-Sun] Sunchon Natl Univ, Res Inst Life & Pharmaceut Sci, Sunchon 57922, South Korea.
C3 Sunchon National University; Sunchon National University
RP Kim, MS (corresponding author), Sunchon Natl Univ, Coll Pharm, Dept Pharm, Sunchon 57922, South Korea.; Kim, MS (corresponding author), Sunchon Natl Univ, Res Inst Life & Pharmaceut Sci, Sunchon 57922, South Korea.
EM duchainguyen1706@gmail.com; minsun@scnu.ac.kr
RI Nguyen Duc, Hai/AAD-8210-2020
OI Nguyen Duc, Hai/0000-0001-8419-7784
FU National Research Foundation of Korea (NRF) [2022R1A2C1005643]
FX This study was supported by National Research Foundation of Korea (NRF)
   (grant no. 2022R1A2C1005643).
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NR 110
TC 24
Z9 25
U1 1
U2 12
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0163-4984
EI 1559-0720
J9 BIOL TRACE ELEM RES
JI Biol. Trace Elem. Res.
PD 2022 JUL 7
PY 2022
DI 10.1007/s12011-022-03343-y
EA JUL 2022
PG 22
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA 2X0TC
UT WOS:000824925400001
PM 35798913
DA 2025-06-11
ER

PT J
AU Malinska, H
   Hüttl, M
   Oliyarnyk, O
   Markova, I
   Poruba, M
   Racova, Z
   Kazdova, L
   Vecera, R
AF Malinska, Hana
   Huttl, Martina
   Oliyarnyk, Olena
   Markova, Irena
   Poruba, Martin
   Racova, Zuzana
   Kazdova, Ludmila
   Vecera, Rostislav
TI Beneficial effects of troxerutin on metabolic disorders in non-obese
   model of metabolic syndrome
SO PLOS ONE
LA English
DT Article
ID OXIDATIVE STRESS; INSULIN-RESISTANCE; HEPATIC EXPRESSION; HIGH-FAT;
   PROTECTS; MUSCLE; CYTOCHROME-P450; CELLS; HEART; RAT
AB Background
   Troxerutin (TRX) has a beneficial effect on blood viscosity and platelet aggregation, and is currently used for the treatment of chronic varicosity. Recently, TRX can improve lipid abnormalities, glucose intolerance and oxidative stress in high-fat diet-induced metabolic disorders. In this study, we tested the effect of TRX on metabolic syndrome-associated disorders using a non-obese model of metabolic syndrome-the Hereditary Hypertriglyceridaemic rats (HHTg).
   Methods
   Adult male HHTg rats were fed standard diet without or with TRX (150 mg/kg bwt/day for 4 weeks).
   Results
   Compared to untreated rats, TRX supplementation in HHTg rats decreased serum glucose (p<0.05) and insulin (p<0.05). Although blood lipids were not affected, TRX decreased hepatic cholesterol concentrations (p<0.01) and reduced gene expression of HMGCR, SREBP2 and SCD1 (p<0.01), involved in cholesterol synthesis and lipid homeostasis. TRX-treated rats exhibited decreased lipoperoxidation and increased activity of antioxidant enzymes SOD and GPx (p<0.05) in the liver. In addition, TRX supplementation increased insulin sensitivity in muscles and epididymal adipose tissue (p<0.05). Elevated serum adiponectin (p<0.05) and decreased muscle triglyceride (p<0.05) helped improve insulin sensitivity. Among the beneficial effects of TRX were changes to cytochrome P450 family enzymes. Hepatic gene expression of CYP4A1, CYP4A3 and CYP5A1 (p<0.01) decreased, while there was a marked elevation in gene expression of CYP1A1 (p<0.01).
   Conclusion
   Our results indicate that TRX improves hepatic lipid metabolism and insulin sensitivity in peripheral tissues. As well as ameliorating oxidative stress, TRX can reduce ectopic lipid deposition, affect genes involved in lipid metabolism, and influence the activity of CYP family enzymes.
C1 [Malinska, Hana; Huttl, Martina; Oliyarnyk, Olena; Markova, Irena] Inst Clin & Expt Med, Ctr Expt Med, Prague, Czech Republic.
   [Poruba, Martin; Racova, Zuzana; Kazdova, Ludmila; Vecera, Rostislav] Palacky Univ, Fac Med & Dent, Dept Pharmacol, Olomouc, Czech Republic.
C3 Institute for Clinical & Experimental Medicine (IKEM); Palacky
   University Olomouc
RP Malínská, H (corresponding author), Inst Clin & Expt Med, Ctr Expt Med, Prague, Czech Republic.
EM hana.malinska@ikem.cz
RI Oliyarnyk, Olena/Q-6380-2019; Stefanadis, Christodoulos/ABH-2232-2020
OI Markova, Irena/0000-0002-4331-7636; Racova, Zuzana/0000-0001-9478-9513;
   Stefanadis, Christodoulos/0000-0001-5974-6454; Poruba,
   Martin/0000-0003-1252-4971; Oliyarnyk, Olena/0000-0002-4912-6187
FU Czech Science Foundation [17-08888S]
FX This work was supported by grant of Czech Science Foundation, project
   number 17-08888S. The funder had no role in study design, data
   collection and analysis, decision to publish, or preparation of the
   manuscript.
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NR 33
TC 19
Z9 19
U1 2
U2 12
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD AUG 12
PY 2019
VL 14
IS 8
AR e0220377
DI 10.1371/journal.pone.0220377
PG 12
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA IW5GN
UT WOS:000485006800012
PM 31404079
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Choi, SH
   Yun, KE
   Choi, HJ
AF Choi, S. H.
   Yun, K. E.
   Choi, H. J.
TI Relationships between serum total bilirubin levels and metabolic
   syndrome in Korean adults
SO NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
LA English
DT Article
DE Metabolic syndrome; Bilirubin; Insulin resistance; Cardiovascular
   disease; Oxidative stress
ID OXIDATIVE STRESS; URIC-ACID; BILIVERDIN REDUCTASE; INSULIN-RESISTANCE;
   NATIONAL-HEALTH; ASSOCIATION; ANTIOXIDANT; DISEASE; ACTIVATION;
   EXPRESSION
AB Background and aims: Metabolic syndrome (MS) is associated with insulin resistance in all parts of its natural history, which is accompanied by oxidative stress. Bilirubin is a potent endogenous antioxidant and cytoprotectant. The current study was performed to identify the major predictors of the total bilirubin level and to assess the relationships between the total bilirubin levels and MS in Korean adults.
   Methods and results: This is a cross-sectional study involving 12342 adults aged 20 years and over who visited a Health Promotion Center. Physical examinations and laboratory tests including total and direct bilirubin levels were performed. MS was defined based on the modified NCEP-ATP III definition and the determinations of the Korean Society for the Study of Obesity. The results showed that hemoglobin had the strongest influence on the total bilirubin levels after adjusting for age, gender, and all other variables. The high-bilirubin group (>= 15.4 mmol/L in males and >= 12.1 mmol/L in females) was associated with significantly decreased odds of MS compared to the low-bilirubin group (OR 0.74 [95% CI 0.64-0.86]). High levels of bilirubin also were negatively associated with abdominal obesity and hypertriglyceridemia. The total bilirubin levels decreased with an increase in the number of MS components after adjustment for all covariates.
   Conclusion: Within the physiological range, the serum total bilirubin level was negatively associated with the MS in subjects without overt metabolic or cardiovascular diseases. This may be partially due to the negative association between the total bilirubin level and abdominal obesity and hypertriglyceridemia. (C) 2011 Elsevier B.V. All rights reserved.
C1 [Choi, S. H.; Yun, K. E.; Choi, H. J.] Eulji Univ Hosp, Dept Family Med, Taejon, South Korea.
C3 Eulji University; Eulji University Hospital
RP Choi, HJ (corresponding author), Eulji Univ Hosp, Dept Family Med, 1306 Dunsan 2Dong, Taejon, South Korea.
EM ohinia@paran.com
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NR 29
TC 80
Z9 83
U1 0
U2 16
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0939-4753
EI 1590-3729
J9 NUTR METAB CARDIOVAS
JI Nutr. Metab. Carbiovasc. Dis.
PD JAN
PY 2013
VL 23
IS 1
BP 31
EP 37
DI 10.1016/j.numecd.2011.03.001
PG 7
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism; Nutrition
   & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism;
   Nutrition & Dietetics
GA 078PO
UT WOS:000314111800010
PM 21703835
DA 2025-06-11
ER

PT J
AU Han, RJ
   Li, AY
   Li, LJ
   Kitlinska, JB
   Zukowska, Z
AF Han, Ruijun
   Li, Aiyun
   Li, Lijun
   Kitlinska, Joanna B.
   Zukowska, Zofia
TI Maternal low-protein diet up-regulates the neuropeptide Y system in
   visceral fat and leads to abdominal obesity and glucose intolerance in a
   sex- and time-specific manner
SO FASEB JOURNAL
LA English
DT Article
DE NPY-Y2R; sex differences; metabolic syndrome
ID ADIPOSE-TISSUE; METABOLIC SYNDROME; FOOD-INTAKE; GROWTH; EXPOSURE;
   PREGNANCY; INSULIN; WEIGHT; STRESS; CELLS
AB Neuropeptide Y (NPY) mediates stress-induced obesity in adult male mice by activating its Y2 receptor (Y2R) in visceral adipose tissue (VAT). Here, we studied whether the NPY-Y2R system is also activated by maternal low-protein diet (LPD) and linked to obesity in offspring. Prenatal LPD offspring had lower birth weights compared to normal-protein diet (NPD) offspring. Female prenatal and lactation stress (PLS) offspring from mothers fed an LPD developed abdominal adiposity and glucose intolerance associated with a 5-fold up-regulation of NPY mRNA and a 6-fold up-regulation of Y2R mRNA specifically in VAT, in addition to elevated platelet-rich-plasma (PRP) NPY, compared to control females fed a high-fat diet (HFD). Conversely, PLS male offspring showed lower NPY in PRP, a 10-fold decrease of Y2R mRNA in VAT, lower adiposity, and improved glucose tolerance compared to control males. Interestingly, prenatal LPD offspring cross-fostered to control lactating mothers had completely inverse metabolic and NPY phenotypes. Taken together, these findings suggested that maternal LPD activates the VAT NPY-Y2R system and increases abdominal adiposity and glucose intolerance in a sex-and time-specific fashion, suggesting that the peripheral NPY system is a potential mediator of programming for the offspring's vulnerability to obesity and metabolic syndrome.-Han, R., Li, A., Li, L., Kitlinska, J. B., Zukowska, Z. Maternal low-protein diet up-regulates the neuropeptide Y system in visceral fat and leads to abdominal obesity and glucose intolerance in a sex-and time-specific manner. FASEB J. 26, 3528-3536 (2012). www.fasebj.org
C1 [Han, Ruijun; Zukowska, Zofia] Univ Minnesota, Dept Integrat Biol & Physiol, Stress Physiol Ctr, Minneapolis, MN 55455 USA.
   [Han, Ruijun; Li, Aiyun; Li, Lijun; Kitlinska, Joanna B.; Zukowska, Zofia] Georgetown Univ, Dept Physiol & Biophys, Washington, DC USA.
C3 University of Minnesota System; University of Minnesota Twin Cities;
   Georgetown University
RP Han, RJ (corresponding author), Univ Minnesota, Dept Integrat Biol & Physiol, Stress Physiol Ctr, 321 Church St SE, Minneapolis, MN 55455 USA.
EM rhan@umn.edu
RI Han, Ruijun/K-6614-2012; Li, Aiyun/IUP-4004-2023
FU U.S. National Institutes of Health [R01HL067357, R37HL055310]
FX This work was supported by U.S. National Institutes of Health grants
   R01HL067357 and R37HL055310 to Z.Z. The authors thank Allison Gurney,
   Amrutesh Puranik, Dalay Hirsch, Jana Strakova, Jixia Liu, Shuangwei Li,
   and Allan V. Kalueff for their insightful comments and editing. The
   authors thank Naz Moaddab for the pilot study reporting that prenatal
   LPD stress increased anxiety in male offspring, with lower NPY levels in
   the amygdala. The authors declare no conflicts of interest.
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NR 48
TC 30
Z9 35
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0892-6638
EI 1530-6860
J9 FASEB J
JI Faseb J.
PD AUG
PY 2012
VL 26
IS 8
BP 3528
EP 3536
DI 10.1096/fj.12-203943
PG 9
WC Biochemistry & Molecular Biology; Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Life Sciences & Biomedicine - Other
   Topics; Cell Biology
GA 984BI
UT WOS:000307162800039
PM 22539639
OA Green Published
DA 2025-06-11
ER

PT J
AU Eirin, A
   Hedayat, AF
   Ferguson, CM
   Textor, SC
   Lerman, A
   Lerman, LO
AF Eirin, Alfonso
   Hedayat, Ahmad F.
   Ferguson, Christopher M.
   Textor, Stephen C.
   Lerman, Amir
   Lerman, Lilach O.
TI Mitoprotection preserves the renal vasculature in porcine metabolic
   syndrome
SO EXPERIMENTAL PHYSIOLOGY
LA English
DT Article
DE cardiolipin; kidney; metabolic syndrome; microvascular; mitochondria
ID GLOMERULAR-FILTRATION-RATE; CHRONIC KIDNEY-DISEASE; ELECTRON-BEAM CT;
   RENOVASCULAR DISEASE; ARTERY STENOSIS; MITOCHONDRIAL BIOENERGETICS;
   OXIDATIVE STRESS; OBESITY; REVASCULARIZATION; HEMODYNAMICS
AB The metabolic syndrome (MetS) induces intrarenal microvascular disease, which may involve mitochondrial injury. The mitochondrial cardiolipin-targeting peptide elamipretide (ELAM) improves the microcirculation in post-stenotic kidneys, but its ability to attenuate MetS-induced renal vascular damage is unknown. We hypothesized that chronic treatment with ELAM would decrease renal vascular remodelling and function in swine MetS. Pigs were studied after 16weeks of diet-induced MetS, MetS treated for the last 4weeks with daily injections of ELAM (0.1mg kg(-1)), and lean control (Lean) animals (n=6 each). Single-kidney regional perfusion, blood flow and glomerular filtration rate were measured with multi-detector computed tomography (CT). Peritubular capillary (PTC) endothelial cell (EC) mitochondrial density and cardiolipin content were assessed in situ, as were PTC-EC apoptosis and oxidative stress. The spatial density of PTCs (Haematoxylin and Eosin staining) and renal microvessels (micro-CT), and renal artery endothelial function (organ bath) were characterized. Regional perfusion and serum creatinine were preserved in MetS pigs, but renal blood flow and glomerular filtration rate were higher compared with Lean. Mitochondrial density and cardiolipin content were diminished in MetS PTC-ECs, but improved in ELAM-treated pigs, as did PTC density. Elamipretide also attenuated PTC-EC oxidative stress and apoptosis. Furthermore, ELAM improved renal microvascular density, decreased microvascular remodelling and restored endothelial nitric oxide expression and endothelium-dependent relaxation of renal artery segments. In conclusion, MetS-induced mitochondrial alterations might contribute to renal PTC and microvascular loss and might impair renal artery endothelial function in pigs. Mitoprotection with ELAM preserved a hierarchy of renal vessels, underscoring its potential to ameliorate renal vascular injury in MetS.
C1 [Eirin, Alfonso; Hedayat, Ahmad F.; Ferguson, Christopher M.; Textor, Stephen C.; Lerman, Lilach O.] Mayo Clin, Div Nephrol & Hypertens, 200 First St SW, Rochester, MN 55901 USA.
   [Lerman, Amir; Lerman, Lilach O.] Mayo Clin, Cardiovasc Dis, Rochester, MN USA.
C3 Mayo Clinic; Mayo Clinic
RP Lerman, LO (corresponding author), Mayo Clin, Div Nephrol & Hypertens, 200 First St SW, Rochester, MN 55901 USA.
EM lerman.lilach@mayo.edu
RI Lerman, Lilach/M-4962-2017; Eirin, Alfonso/N-9873-2013
OI Eirin, Alfonso/0000-0002-3864-9644
FU Stealth Biotherapeutics, Inc.; National Institutes of Health [DK106427,
   DK104273, HL123160, DK102325]
FX This work was supported by a research grant from Stealth
   Biotherapeutics, Inc., and from the National Institutes of Health
   (DK106427, DK104273, HL123160 and DK102325).
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NR 43
TC 18
Z9 19
U1 0
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0958-0670
EI 1469-445X
J9 EXP PHYSIOL
JI Exp. Physiol.
PD JUL 1
PY 2018
VL 103
IS 7
BP 1020
EP 1029
DI 10.1113/EP086988
PG 10
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA GL0SU
UT WOS:000436801500010
PM 29714040
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Wolf, EJ
   Bovin, MJ
   Green, JD
   Mitchell, KS
   Stoop, TB
   Barretto, KM
   Jackson, CE
   Lee, LO
   Fang, SC
   Trachtenberg, F
   Rosen, RC
   Keane, TM
   Marx, BP
AF Wolf, E. J.
   Bovin, M. J.
   Green, J. D.
   Mitchell, K. S.
   Stoop, T. B.
   Barretto, K. M.
   Jackson, C. E.
   Lee, L. O.
   Fang, S. C.
   Trachtenberg, F.
   Rosen, R. C.
   Keane, T. M.
   Marx, B. P.
TI Longitudinal associations between post-traumatic stress disorder and
   metabolic syndrome severity
SO PSYCHOLOGICAL MEDICINE
LA English
DT Article
DE Accelerated aging; cross-lagged design; longitudinal; metabolic
   syndrome; PTSD; veterans
ID EARLY-LIFE ADVERSITY; BODY-MASS INDEX; CARDIOVASCULAR-DISEASE;
   RISK-FACTORS; PHYSICAL-ACTIVITY; OXIDATIVE STRESS; PTSD; SYMPTOMS;
   PEOPLE; AFGHANISTAN
AB Background. Post-traumatic stress disorder (PTSD) is associated with elevated risk for metabolic syndrome (MetS). However, the direction of this association is not yet established, as most prior studies employed cross-sectional designs. The primary goal of this study was to evaluate bidirectional associations between PTSD and MetS using a longitudinal design.
   Method. A total of 1355 male and female veterans of the conflicts in Iraq and Afghanistan underwent PTSD diagnostic assessments and their biometric profiles pertaining to MetS were extracted from the electronic medical record at two time points (spanning similar to 2.5 years, n = 971 at time 2).
   Results. The prevalence of MetS among veterans with PTSD was just under 40% at both time points and was significantly greater than that for veterans without PTSD; the prevalence of MetS among those with PTSD was also elevated relative to age-matched population estimates. Cross-lagged panel models revealed that PTSD severity predicted subsequent increases in MetS severity (beta = 0.08, p = 0.002), after controlling for initial MetS severity, but MetS did not predict later PTSD symptoms. Logistic regression results suggested that for every 10 PTSD symptoms endorsed at time 1, the odds of a subsequent MetS diagnosis increased by 56%.
   Conclusions. Results highlight the substantial cardiometabolic concerns of young veterans with PTSD and raise the possibility that PTSD may predispose individuals to accelerated aging, in part, manifested clinically as MetS. This demonstrates the need to identify those with PTSD at greatest risk for MetS and to develop interventions that improve both conditions.
C1 [Wolf, E. J.; Bovin, M. J.; Mitchell, K. S.; Keane, T. M.; Marx, B. P.] VA Boston Healthcare Syst, Natl Ctr PTSD, Boston, MA USA.
   [Wolf, E. J.; Bovin, M. J.; Green, J. D.; Mitchell, K. S.; Jackson, C. E.; Lee, L. O.; Keane, T. M.; Marx, B. P.] Boston Univ, Sch Med, Dept Psychiat, Boston, MA 02118 USA.
   [Green, J. D.; Barretto, K. M.; Lee, L. O.] VA Boston Healthcare Syst, Res Serv, Boston, MA USA.
   [Stoop, T. B.] Boston VA Res Inst, Boston, MA USA.
   [Jackson, C. E.] VA Boston Healthcare Syst, Educ & Clin Ctr, Geriatr Res, Boston, MA USA.
   [Jackson, C. E.] VA Boston Healthcare Syst, Translat Res Ctr TBI & Stress Disorders, Boston, MA USA.
   [Fang, S. C.; Trachtenberg, F.; Rosen, R. C.] New England Res Inst, Watertown, MA USA.
C3 Harvard University; Harvard University Medical Affiliates; US Department
   of Veterans Affairs; Veterans Health Administration (VHA); VA Boston
   Healthcare System; Boston University; Harvard University; Harvard
   University Medical Affiliates; US Department of Veterans Affairs;
   Veterans Health Administration (VHA); VA Boston Healthcare System;
   Harvard University; Harvard University Medical Affiliates; US Department
   of Veterans Affairs; Veterans Health Administration (VHA); VA Boston
   Healthcare System; Geriatric Research Education & Clinical Center;
   Harvard University; Harvard University Medical Affiliates; US Department
   of Veterans Affairs; Veterans Health Administration (VHA); VA Boston
   Healthcare System; HealthCore, Inc
RP Wolf, EJ; Marx, BP (corresponding author), VA Boston Healthcare Syst, Natl Ctr PTSD 116B 2, 150 South Huntington Ave, Boston, MA 02130 USA.
EM erika.wolf@va.gov; brian.marx@va.gov
RI Marx, Brian/AAK-5072-2020; Bovin, Michelle/AEW-4717-2022; Keane,
   Terence/I-8253-2014
OI Keane, Terence/0000-0002-0482-3149; Lee, Lewina/0000-0002-1652-8198;
   Bovin, Michelle/0000-0002-3296-4360; Jackson,
   Colleen/0000-0002-9927-2684; Wolf, Erika/0000-0003-2666-2435; Marx,
   Brian/0000-0001-8988-1796
FU United States Department of Veterans Affairs, Clinical Sciences Research
   and Development Program; Department of Defense [W81XWH-08-2-0100,
   W81XWH-12-2-0117, W81XWH-10-2-0181, W81XWH-12-1-0532, W81XWH-14-2-0139,
   W81XWH-08-2-0102, W81XWH-12-2-0121]; National Institute of Mental Health
   [1R01MH095737-01A1, 5T32MH019836-16, K01MH093750]; Defense Advanced
   Research Programs Agency [N66001-11-C-4006]; Department of Veterans
   Affairs [591]; Consortium to Alleviate PTSD; National Institute on Aging
   [K08AG048221]; National Center for Advancing Translational Sciences
   [1UL1TR001430]
FX This work was supported by a Career Development Award to Erika J. Wolf
   from the United States Department of Veterans Affairs, Clinical Sciences
   Research and Development Program. Brian Marx and Terence Keane were
   supported by funding from the Department of Defense (W81XWH-08-2-0100,
   W81XWH-12-2-0117). Dr. Marx was additionally supported by funding from
   the National Institute of Mental Health (1R01MH095737-01A1), Defense
   Advanced Research Programs Agency (N66001-11-C-4006), and Department of
   Defense (W81XWH-10-2-0181), and the Department of Veterans Affairs
   (Cooperative Studies Program no. 591). Dr. Keane was additionally
   supported by funding from the Consortium to Alleviate PTSD and National
   Institute of Mental Health (5T32MH019836-16). Raymond Rosen was
   supported by funding from the Department of Defense, (W81XWH-12-1-0532;
   W81XWH-14-2-0139; W81XWH-08-2-0102, and W81XWH-12-2-0121). Karen
   Mitchell's contribution was partly supported by funding from the
   National Institute of Mental Health (K01MH093750). Lewina Lee was
   supported by funding from the National Institute on Aging (K08AG048221)
   and the National Center for Advancing Translational Sciences (BU-CTSI
   Grant Number 1UL1TR001430). The contents of this article do not
   represent the views of the U.S. Department of Veterans Affairs or the
   United States Government.
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NR 65
TC 59
Z9 65
U1 1
U2 23
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0033-2917
EI 1469-8978
J9 PSYCHOL MED
JI Psychol. Med.
PD JUL
PY 2016
VL 46
IS 10
BP 2215
EP 2226
DI 10.1017/S0033291716000817
PG 12
WC Psychology, Clinical; Psychiatry; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA DQ4GV
UT WOS:000379163000017
PM 27087657
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Zhang, M
   Liu, B
   Ke, WY
   Cai, YS
   Zhang, LY
   Huang, WX
   Yan, XH
   Chen, HF
AF Zhang, Min
   Liu, Bin
   Ke, Weiyi
   Cai, Yashi
   Zhang, Lingyu
   Huang, Weixu
   Yan, Xuehua
   Chen, Huifeng
TI Correlation analysis between occupational stress and metabolic syndrome
   in workers of a petrochemical enterprise: based on two assessment models
   of occupational stress
SO BMC PUBLIC HEALTH
LA English
DT Article
DE Occupational stress; Job demand-control; Effort-reward imbalance;
   Metabolic syndrome; Petrochemical enterprise
ID EFFORT-REWARD IMBALANCE; JOB DEMAND-CONTROL; CARDIOVASCULAR-DISEASE;
   SOCIAL SUPPORT; BLOOD-PRESSURE; RISK-FACTORS; HEALTH; SMOKING;
   PATHOPHYSIOLOGY; ASSOCIATIONS
AB Background Occupational stress is becoming a common phenomenon around the world. Being in a high occupational stress state for a long time may destroy the metabolic balance of the body, thereby increasing the risk of metabolic diseases. There is limited evidence regarding the correlation between occupational stress and metabolic syndrome (MetS), particularly in the petrochemical workers. Methods A total of 1683 workers of a petrochemical enterprise in China were included in the survey by cluster sampling method. The occupational stress assessment was carried out by the Job Content Questionnaire and the Effort-Reward Imbalance Questionnaire, and the general demographic characteristics, work characteristics, occupational hazards, lifestyle and health examination data of the participants were collected. Logistic regression and multiple linear regression were used to analyze the correlations and influencing factors between occupational stress and its dimensions with MetS and its components. Results A total of 1683 questionnaires were sent out, and 1608 were effectively collected, with an effective recovery rate of 95.54%. The detection rates of occupational stress in Job Demand-Control (JDC) and Effort-Reward Imbalance (ERI) models were 28.4% and 27.2%, respectively. In this study, 257 participants (16.0%) were diagnosed with MetS. Compared with the non-MetS group, body mass index (BMI), waist circumference (WC), systolic blood pressure (SBP), diastolic blood pressure (DBP), triglycerides (TG) and fasting blood-glucose (FBG) levels were significantly higher in the MetS group, and high density lipoprotein-cholesterol (HDL-C) levels were significantly lower (P < 0.001). The results of multiple linear regression showed that after adjusting for nation, marital status, education, work system, smoking and drinking, and further adjusting for occupational hazards, the D/C ratio was significantly negatively correlated with SBP in the JDC model. Social support was negatively correlated with WC. In the ERI model, there was a significant positive correlation between over-commitment and FBG. Conclusions The detection rates of occupational stress and MetS were high in workers of a petrochemical enterprise. In the JDC model, occupational stress was negatively correlated with SBP, and social support was negatively correlated with WC. In the ERI model, there was a significantly positive correlation between over-commitment and FBG.
C1 [Zhang, Min; Ke, Weiyi; Cai, Yashi; Zhang, Lingyu; Huang, Weixu; Yan, Xuehua; Chen, Huifeng] Guangdong Prov Hosp Occupat Dis Prevent & Treatmen, Guangzhou 510300, Guangdong, Peoples R China.
   [Zhang, Min; Chen, Huifeng] Shanxi Med Univ, Sch Publ Hlth, Taiyuan 030001, Shanxi, Peoples R China.
   [Liu, Bin] Shenzhen Luohu Peoples Hosp, Shenzhen 518000, Guangdong, Peoples R China.
C3 Shanxi Medical University; Shenzhen Luohu Hospital Group Luohu People's
   Hospital
RP Yan, XH; Chen, HF (corresponding author), Guangdong Prov Hosp Occupat Dis Prevent & Treatmen, Guangzhou 510300, Guangdong, Peoples R China.; Chen, HF (corresponding author), Shanxi Med Univ, Sch Publ Hlth, Taiyuan 030001, Shanxi, Peoples R China.
EM yanxh2004@126.com; hfchen2001@163.com
RI zhang, min/LXV-6029-2024
OI Chen, Huifeng/0000-0002-5381-1793; Lingyu, Zhang/0000-0001-8717-7412
FU Medical Scientific Research Foundation of Guangdong Province [A2019246,
   A2021209]; Guangzhou Science and Technology Plan Project [202102080135]
FX We gratefully acknowledge funding from the Medical Scientific Research
   Foundation of Guangdong Province (grant numbers: A2019246, A2021209) and
   the Guangzhou Science and Technology Plan Project (grant numbers:
   202102080135).
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NR 68
TC 4
Z9 5
U1 2
U2 4
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2458
J9 BMC PUBLIC HEALTH
JI BMC Public Health
PD MAR 14
PY 2024
VL 24
IS 1
AR 802
DI 10.1186/s12889-024-18305-3
PG 14
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA LG3Z1
UT WOS:001185603900004
PM 38486274
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Sadeghi-Dehsahraei, H
   Babajafari, S
   Ashrafi, M
   Mohammadi-Sartang, M
AF Sadeghi-Dehsahraei, Hamed
   Babajafari, Siavash
   Ashrafi, Mahboobeh
   Mohammadi-Sartang, Mohsen
TI Comparison of the effect of consuming the prepared cakes with acorn
   flour and wheat flour following a hypocaloric diet on serum levels of
   leptin, endothelin, inflammatory factors, and oxidative stress
   parameters in obese and overweight patients with metabolic syndrome: A
   double-blind clinical trial
SO FOOD SCIENCE & NUTRITION
LA English
DT Article
DE acorn; metabolic syndrome; MetS; obesity
ID FUNCTIONAL FOODS; INSULIN-RESISTANCE; EXTRACT; ACID; BARK; PRODUCTS
AB Metabolic syndrome (MetS), which is a major consequence of obesity, increases mortality risks. Evidence shows favorable effects of nutritional approaches in the management of MetS. Accordingly, the use of functional foods has increased to enhance weight loss and reduce the risk factors associated with MetS. So, we aimed to investigate the effects of daily consumption of a functional acorn-based cake in conjunction with energy-restricted diet on some complications of patients with MetS. The study included 66 participants who were randomly assigned to either (A) a calorie-restricted diet + functional cake (FC) (n = 33) or (B) a calorie-restricted diet + a placebo cake (PC) (n = 33). Sociodemographic information, anthropometric measurements, dietary intakes, and serum biochemical parameters (inflammatory and oxidative stress markers, leptin, and endothelin) were measured before and after 8 weeks of intervention. Sixty-three participants completed this trial. After adjustment for baseline levels, consumption of FC compared to the PC resulted in a significant decrease in IL-6 (p = .03) and high-sensitivity C-reactive protein (p = .04) levels. No differences were observed between groups with regard to serum malondialdehyde, total antioxidant capacity, endothelin, and leptin levels (p > .05). Acorn-based cake could improve inflammation as an adjunct to an energy-restricted diet in overweight and obese patients with MetS. However, it is not clear whether acorn-based cake can be used to prevent or treat MetS because of indecisive findings regarding its ability to manage oxidative stress and serum hormones.
C1 [Sadeghi-Dehsahraei, Hamed; Ashrafi, Mahboobeh] Shiraz Univ, Sch Vet Med, Dept Basic Sci, Shiraz, Iran.
   [Babajafari, Siavash; Mohammadi-Sartang, Mohsen] Shiraz Univ Med Sci, Nutr Res Ctr, Sch Nutr & Food Sci, Shiraz, Iran.
C3 Shiraz University; Shiraz University of Medical Science
RP Ashrafi, M (corresponding author), Shiraz Univ, Sch Vet Med, Dept Basic Sci, Shiraz, Iran.
EM mashrafi@shirazu.ac.ir
RI Esfandabad, Siavash/A-6807-2019
FU Shiraz University [1400-03- 21]
FX Shiraz University, Grant/Award Number: 1400-03- 21
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NR 46
TC 0
Z9 0
U1 2
U2 5
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2048-7177
J9 FOOD SCI NUTR
JI Food Sci. Nutr.
PD OCT
PY 2024
VL 12
IS 10
BP 8043
EP 8052
DI 10.1002/fsn3.4393
EA AUG 2024
PG 10
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA K6D2F
UT WOS:001294760300001
PM 39479683
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Anraku, M
   Michihara, A
   Yasufuku, T
   Akasaki, K
   Tsuchiya, D
   Nishio, H
   Maruyama, T
   Otagiri, M
   Maezaki, Y
   Kondo, Y
   Tomida, H
AF Anraku, Makoto
   Michihara, Akihiro
   Yasufuku, Taira
   Akasaki, Kenji
   Tsuchiya, Daiju
   Nishio, Hiroaki
   Maruyama, Toru
   Otagiri, Masaki
   Maezaki, Yuji
   Kondo, Yuko
   Tomida, Hisao
TI The Antioxidative and Antilipidemic Effects of Different Molecular
   Weight Chitosans in Metabolic Syndrome Model Rats
SO BIOLOGICAL & PHARMACEUTICAL BULLETIN
LA English
DT Article
DE metabolic syndrome; chitosan; antilipidemic effect; antioxidant activity
ID OXIDATIVE STRESS; REDUCTION; ALBUMIN; ATHEROSCLEROSIS; ABSORPTION;
   DISEASE; ACID
AB The effect of high and low molecular weight chitosans (HMC, 1000 kDa, LMC, 30 kDa) on oxidative stress and hypercholesterolemia was investigated using male 6-week-old Wistar Kyoto rats as a normal model (Normal-rats) and spontaneously hypertensive rat/ND mcr-cp (SHP/ND) as a metabolic syndrome model (MS-rats), respectively In Normal-rats, the ingestion of both chitosans over a 4 week period resulted in a significant decrease in total body weight (BW), glucose (Cl), triglyceride (TG), low density lipoprotein (LDL) and serum creatinine (Cre) levels The ingestion of both chitosans also resulted in a lowered ratio of oxidized to reduced albumin and an Increase in total plasma antioxidant activity In addition to similar results in Normal-rats, the ingestion of only HMC over a 4 week period resulted in a significant decrease in total cholesterol levels in MS-rats Further, the ingestion of LMC resulted in a significantly higher antioxidant activity than was observed for HMC in both rat models In in vitro studies, LMC caused a significantly higher reduction in the levels of two stable radicals, compared to HMC, and the effect was both dose- and time-dependent The findings also show that LDL showed strong binding in the case of HMC These results suggest that LMC has a high antioxidant activity as well as antilipidemic effects, while HMC results in a significant reduction in the levels of pro-oxidants such as LDL in the gastrointestinal tract, thereby inhibiting the subsequent development of oxidative stress in the systemic circulation in metabolic model rats
C1 [Anraku, Makoto; Michihara, Akihiro; Yasufuku, Taira; Akasaki, Kenji; Tsuchiya, Daiju; Nishio, Hiroaki; Kondo, Yuko; Tomida, Hisao] Fukuyama Univ, Fac Pharm & Pharmaceut Sci, Fukuyama, Hiroshima 7290292, Japan.
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   [Maezaki, Yuji] Nippon Kayaku Food Techno Co Ltd, Gunma 3701208, Japan.
   [Otagiri, Masaki] Sojo Univ, Fac Pharmaceut Sci, Kumamoto 8600082, Japan.
C3 Fukuyama University; Kumamoto University; Nippon Kayaku Co., Ltd.; Sojo
   University
RP Tomida, H (corresponding author), Fukuyama Univ, Fac Pharm & Pharmaceut Sci, 1 Sanzo Gakuen Cho, Fukuyama, Hiroshima 7290292, Japan.
RI Anraku, Makoto/AAA-3935-2020; Maruyama, Toru/NFS-8627-2025
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NR 32
TC 28
Z9 28
U1 0
U2 12
PU PHARMACEUTICAL SOC JAPAN
PI TOKYO
PA 2-12-15 SHIBUYA, SHIBUYA-KU, TOKYO, 150-0002, JAPAN
SN 0918-6158
J9 BIOL PHARM BULL
JI Biol. Pharm. Bull.
PD DEC
PY 2010
VL 33
IS 12
BP 1994
EP 1998
DI 10.1248/bpb.33.1994
PG 5
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 688OZ
UT WOS:000284862200013
PM 21139239
OA Bronze
DA 2025-06-11
ER

PT J
AU Pilar, B
   Güllich, A
   Oliveira, P
   Ströher, D
   Piccoli, J
   Manfredini, V
AF Pilar, Bruna
   Gullich, Angelica
   Oliveira, Patricia
   Stroher, Deise
   Piccoli, Jacqueline
   Manfredini, Vanusa
TI Protective Role of Flaxseed Oil and Flaxseed Lignan Secoisolariciresinol
   Diglucoside Against Oxidative Stress in Rats with Metabolic Syndrome
SO JOURNAL OF FOOD SCIENCE
LA English
DT Article
DE antioxidant; flaxseed oil; metabolic syndrome; oxidative stress;
   secoisolariciresinol diglucoside
ID PROTEIN; ANTIOXIDANTS; CHOLESTEROL; PLASMA; DAMAGE
AB This study evaluated the protective effect of flaxseed oil (FO) and flaxseed lignan secoisolariciresinol diglucoside (SDG) against oxidative stress in rats with metabolic syndrome (MS). 48 rats were allocated into the following 6 groups: Groups 1 (control), 5 (FO), and 6 (SDG) received water and were treated daily orally with saline, FO, and SDG, respectively. Groups 2 (MS), 3 (MS+FO), and 4 (MS+SDG) received 30% fructose in drinking water for MS induction and were treated daily orally with saline, FO, and SDG, respectively. After 30 d, animals were sacrificed, and blood was collected for biochemical and oxidative analysis. Body weight was recorded weekly. Systolic blood pressure (SBP) was measured before and after treatment. Fructose could produce MS and oxidative stress. FO and SDG prevented changes in SBP, lipids, and glucose. FO and SDG prevented oxidative damage to lipids, and only FO prevented oxidative damage to proteins associated to MS. FO and SDG improved enzymatic antioxidants defenses and reduced glutathione levels, which was greater with SDG. Total polyphenol levels were enhanced in groups that received SDG. Thus, the results of this study demonstrated that treatment with a 30% fructose solution for 30 d is effective for MS induction and the oxidative stress is involved in the pathophysiology of MS induced by fructose-rich diets. Furthermore, we demonstrated that the antioxidant effects attributed to flaxseed are mainly due to its high lignan content especially that of SDG, suggesting that this compound can be used in isolation to prevent oxidative stress associated with MS.
   Practical ApplicationWe report that the antioxidant effects attributed to flaxseed are mainly due to its high lignan content, especially that of secoisolariciresinol diglucoside. This is significant because suggests that this compound can be used in isolation to prevent oxidative stress associated with MS. Furthermore, this study was the only one to perform a comparison of the abilities of 2 components of flaxseed to protect against oxidative stress in an MS model, which brings a great advance in the medicine's field, since it indicates another alternative for improve the health and the quality of life of patients with this disorder.
C1 [Pilar, Bruna; Gullich, Angelica; Oliveira, Patricia; Stroher, Deise; Manfredini, Vanusa] Fed Univ Pampa, Postgrad Program Biochem, Uruguaiana, RS, Brazil.
   [Piccoli, Jacqueline] Fed Univ Pampa, Postgrad Program Pharmaceut Sci, Uruguaiana, RS, Brazil.
C3 Universidade Federal do Pampa; Universidade Federal do Pampa
RP Pilar, B (corresponding author), Fed Univ Pampa, Postgrad Program Biochem, Uruguaiana, RS, Brazil.
EM brunapilar16@hotmail.com
RI Piccoli, Jacqueline/AFQ-2824-2022
OI Pp, Jenny/0000-0001-6722-3813
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NR 48
TC 39
Z9 43
U1 0
U2 37
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-1147
EI 1750-3841
J9 J FOOD SCI
JI J. Food Sci.
PD DEC
PY 2017
VL 82
IS 12
BP 3029
EP 3036
DI 10.1111/1750-3841.13964
PG 8
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA FP6WA
UT WOS:000417766000031
PM 29083494
DA 2025-06-11
ER

PT J
AU Rachmawati, E
   Rohman, MS
   Widodo, N
   Lukitasari, M
   Nugroho, DA
   Hermanto, FE
   Kholis, MN
AF Rachmawati, Ermin
   Rohman, Mohammad S.
   Widodo, Nashi
   Lukitasari, Mifetika
   Nugroho, Dwi A.
   Hermanto, Feri E.
   Kholis, Mukhamad N.
TI The analysis of coffee-green tea-turmeric combination against
   cardiac-metabolic syndrome using metabolite profiling, gene expression,
   and in silico approach
SO JOURNAL OF PHARMACY & PHARMACOGNOSY RESEARCH
LA English
DT Article
DE calcium handling; coffee; green tea; inflammation; oxidative stress;
   turmeric
ID CARDIOMYOCYTES; POLYMORPHISMS; INFLAMMATION; DYSFUNCTION; SERCA
AB Context: The development of functional drinks to inhibit oxidative stress and inflammation as a critical process in inducing heart damage in metabolic syndrome is required. Coffee, tea, and turmeric have all been shown to offer health advantages.Aims: To investigate the effect of coffee, green tea, turmeric extract (ECGTT) against cardiac-metabolic syndrome (MetS).Methods: The secondary metabolites from coffee, green tea, and turmeric were identified using LC-HRMS. Male Sprague-Dawley rats were divided into four groups (n = 4) representing normal, MetS, MetS with ECGTT treatment doses: 300/100/150 mg/BW and 300/100/250 mg/BW group. Upon the end of treatment periods, expression of tumor necrosis factor-alpha (TNF alpha), interleukin-6 (IL-6), nuclear factor kappa B (NF-kappa B), NADPH oxidase (NOX2), SERCA2a were measured from the heart. A computational approach including network pharmacology, protein-protein interaction (PPI) network, molecular docking, and dynamic was performed to understand the molecular mechanism of ECGTT against cardiac damage in MetS.Results: Chlorogenic acid (CGA), epigallocatechin gallate (EGCG), and curcumin were identified as the main metabolites in ECGTT. The ECGTT administration decreased the TNF alpha, IL-6, NF-kappa B, and NOX2 and increased SERCA2a expression(p<0.05). Moreover, the PPI result suggested that angiotensin II receptor type 1 (AGTR1) was the key regulator of cardiac injury-MetS induced. CGA, EGCG, and curcumin bind to AGTR1 with smaller binding energy than metformin and showed stability of structure and interaction among those metabolites into AGTR1.Conclusions: Coffee, green tea, and turmeric might prevent heart dysfunction in MetS through modulation of oxidative stress and inflammation.
C1 [Rachmawati, Ermin; Rohman, Mohammad S.; Widodo, Nashi; Lukitasari, Mifetika; Nugroho, Dwi A.; Hermanto, Feri E.; Kholis, Mukhamad N.] Brawijaya Univ, Res Ctr Cardiovasc, Malang, Indonesia.
   [Rachmawati, Ermin; Kholis, Mukhamad N.] UIN Maulana Malik Ibrahim Malang, Fac Med & Hlth Sci, Dept Biomed Sci, East Java, Indonesia.
   [Rohman, Mohammad S.] Univ Brawijaya, Fac Med, Dept Cardiol & Vasc Med, Malang, Indonesia.
   [Widodo, Nashi] Univ Brawijaya, Fac Math & Nat Sci, Dept Biol, Malang, Indonesia.
   [Lukitasari, Mifetika] Univ Brawijaya, Fac Hlth Sci, Sch Nursing, Malang, Indonesia.
   [Hermanto, Feri E.] Univ Brawijaya, Fac Anim Sci, Malang, Indonesia.
   [Hermanto, Feri E.] Indonesian Inst Bioinformat, Bioinformat Res Ctr, Malang, Indonesia.
C3 Brawijaya University; Brawijaya University; Brawijaya University;
   Brawijaya University; Brawijaya University
RP Rachmawati, E; Rohman, MS (corresponding author), Brawijaya Univ, Res Ctr Cardiovasc, Malang, Indonesia.; Rachmawati, E (corresponding author), UIN Maulana Malik Ibrahim Malang, Fac Med & Hlth Sci, Dept Biomed Sci, East Java, Indonesia.; Rohman, MS (corresponding author), Univ Brawijaya, Fac Med, Dept Cardiol & Vasc Med, Malang, Indonesia.
EM ermin.rachmawati@kedokteran.uin-malang.ac.id; ippoenk@ub.ac.id
RI Rohman, Mohammad Saifur/JGM-7412-2023; Hermanto, Feri/HTL-5975-2023;
   Nugroho, Dwi Adi/GPX-4098-2022; WIDODO, WIDODO/JGL-6847-2023
OI Hermanto, Feri Eko/0000-0002-6955-3688; Rachmawati,
   Ermin/0000-0003-1045-7066; , Widodo/0000-0002-1126-498X; Saifur Rohman,
   Mohammad/0000-0001-6461-2223
FU Universitas Brawijaya, Indonesia [6780/2022]
FX Authors thank to Universitas Brawijaya, Indonesia for the grant Program
   Hibah Penelitian Doktor Dan Profesor Tahun Anggaran 2022 No. 6780/2022.
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NR 38
TC 0
Z9 0
U1 0
U2 2
PU JOURNAL PHARMACY & PHARMACOGNOSY RESEARCH-JPPRES
PI ANTOFAGASTA
PA ANGAMOS 0610, ANTOFAGASTA, 00000, CHILE
SN 0719-4250
J9 J PHARM PHARMACOGN R
JI J. Pharm. Pharmacogn. Res.
PD NOV-DEC
PY 2023
VL 11
IS 6
BP 961
EP 974
DI 10.56499/jppres23.1702_11.6.961
PG 14
WC Pharmacology & Pharmacy
WE Emerging Sources Citation Index (ESCI)
SC Pharmacology & Pharmacy
GA X1QS5
UT WOS:001096269900004
OA gold, Green Accepted
DA 2025-06-11
ER

PT J
AU Park, AY
   Cha, S
AF Park, Ah Yeon
   Cha, Seongwon
TI Effects of cold sensitivity in the extremities on circulating
   adiponectin levels and metabolic syndrome in women
SO BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Article
DE Cold hypersensitivity in the hands and feet; High-molecular-weight
   adiponectin; Metabolic syndrome; Emotional cold stress; Extremities
ID POSTMENOPAUSAL WOMEN; ADIPOSE-TISSUE; HANDS; ASSOCIATION; LEPTIN;
   PROTOCOL; RATIO; FEET
AB Background: In adipose tissues, adipokine levels, including adiponectin and leptin, are involved in insulin sensitivity and are reciprocally induced by cold temperature stress. Thermogenic response in the extremities (hands and feet) against cold stress can be negatively related to fat mass accumulation, particularly in the abdomen. However, the relationship between the sensation of cold in the extremities and circulating levels of adipokines is not fully understood. Here, we investigated whether adipokine levels are associated with cold hypersensitivity in the hands and feet (CHHF), independent of body mass, and whether the CHHF is related to metabolic syndrome (MS).
   Methods: Associations of the CHHF with serum levels of adipokines and MS risk were evaluated in 1021 Koreans (372 men and 649 women), using a linear regression model while controlling for thermogenic factors and a logistic regression model, respectively.
   Results: The adiponectin levels were positively associated with the CHHF, particularly in women, irrespective of thermogenic factors, including body mass index (beta = 1.23 mu g/mL, 95% confidence interval [1.04-1.45]). Logistic regression analysis for MS risk via the CHHF showed that there was a significant inverse association in women (odds ratio = 0.449, 95% confidence interval [0.273-0.737]).
   Conclusions: In summary, our founding indicated that the CHHF could induce increased levels of circulating adiponectin and in turn reduce the MS risk in women. Despite complaints of feeling cold, these women could be at lower risk of cardiovascular disease.
C1 [Park, Ah Yeon; Cha, Seongwon] Korea Inst Oriental Med, Mibyeong Res Ctr, 1672 Yuseongdae Ro, Daejeon 34054, South Korea.
C3 Korea Institute of Oriental Medicine (KIOM)
RP Cha, S (corresponding author), Korea Inst Oriental Med, Mibyeong Res Ctr, 1672 Yuseongdae Ro, Daejeon 34054, South Korea.
EM scha@kiom.re.kr
RI Cha, Seongwon/A-2377-2012
OI Cha, Seongwon/0000-0001-9012-8718
FU National Research Foundation of Korea (NRF) - Ministry of Science, ICT &
   Future Planning [NRF-2014M3A9D7034335]; research program of Korea
   Institute of Oriental Medicine [K17092]
FX This research was supported by the National Research Foundation of Korea
   (NRF) funded by the Ministry of Science, ICT & Future Planning (grant
   no. NRF-2014M3A9D7034335) and by the research program of Korea Institute
   of Oriental Medicine (grant no. K17092). The funders had no role in
   study design, data collection and analysis, interpretation of data, and
   preparation of the manuscript.
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NR 28
TC 11
Z9 12
U1 0
U2 1
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1472-6882
J9 BMC COMPLEM ALTERN M
JI BMC Complement. Altern. Med.
PD MAR 9
PY 2017
VL 17
AR 150
DI 10.1186/s12906-017-1658-7
PG 9
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA EN8UB
UT WOS:000396274200006
PM 28279166
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Black, HS
AF Black, Homer S.
TI A Synopsis of the Associations of Oxidative Stress, ROS, and
   Antioxidants with Diabetes Mellitus
SO ANTIOXIDANTS
LA English
DT Review
DE diabetes mellitus; oxidative stress; ROS; antioxidants; metabolic
   syndrome
ID ELECTRON-TRANSPORT CHAIN; FREE FATTY-ACIDS; INSULIN-RESISTANCE;
   METABOLIC SYNDROME; LIPID-PEROXIDATION; REDOX IMBALANCE; POLYOL PATHWAY;
   ADIPOSE-TISSUE; TYPE-2; HYPERGLYCEMIA
AB The Greek physician, Aretaios, coined the term "diabetes" in the 1st Century A.D. "Mellitus" arose from the observation that the urine exhibits a sweetness due to its elevated glucose levels. Diabetes mellitus (DM) accounted for 6.7 million deaths globally in 2021 with expenditures of USD 966 billion. Mortality is predicted to rise nearly 10-fold by 2030. Oxidative stress, an imbalance between the generation and removal of reactive oxygen species (ROS), is implicated in the pathophysiology of diabetes. Whereas ROS are generated in euglycemic, natural insulin-regulated glucose metabolism, levels are regulated by factors that regulate cellular respiration, e.g., the availability of NAD-linked substrates, succinate, and oxygen; and antioxidant enzymes that maintain the cellular redox balance. Only about 1-2% of total oxygen consumption results in the formation of superoxide anion and hydrogen peroxide under normal reduced conditions. However, under hyperglycemic conditions, about 10% of the respiratory oxygen consumed may be lost as free radicals. Under hyperglycemic conditions, the two-reaction polyol pathway is activated. Nearly 30% of blood glucose can flux through this pathway-a major path contributing to NADH/NAD(+) redox imbalance. Under these conditions, protein glycation and lipid peroxidation increase, and inflammatory cytokines are formed, leading to the further formation of ROS. As mitochondria are the major site of intracellular ROS, these organelles are subject to the deleterious effects of ROS themselves and eventually become dysfunctional-a milestone in Metabolic Syndrome (MetS) of which insulin resistance and diabetes predispose to cardiovascular disease.
C1 [Black, Homer S.] Baylor Coll Med, Dept Dermatol, Houston, TX 77030 USA.
C3 Baylor College of Medicine
RP Black, HS (corresponding author), Baylor Coll Med, Dept Dermatol, Houston, TX 77030 USA.
EM hblack@bcm.edu
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NR 80
TC 52
Z9 52
U1 5
U2 40
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD OCT
PY 2022
VL 11
IS 10
AR 2003
DI 10.3390/antiox11102003
PG 16
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA 5N8EG
UT WOS:000872020000001
PM 36290725
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Auberval, N
   Dal, S
   Maillard, E
   Bietiger, W
   Peronet, C
   Pinget, M
   Schini-Kerth, V
   Sigrist, S
AF Auberval, Nathalie
   Dal, Stephanie
   Maillard, Elisa
   Bietiger, William
   Peronet, Claude
   Pinget, Michel
   Schini-Kerth, Valerie
   Sigrist, Severine
TI Beneficial effects of a red wine polyphenol extract on high-fat
   diet-induced metabolic syndrome in rats
SO EUROPEAN JOURNAL OF NUTRITION
LA English
DT Article
DE Metabolic syndrome; Oxidative stress; Highfat-diet rats; Red wine
   polyphenols
ID HEPATIC INSULIN-RESISTANCE; OXIDATIVE STRESS; ENDOTHELIAL DYSFUNCTION;
   LIVER; MANAGEMENT; MECHANISM; RECEPTOR; OBESITY; SYSTEM; HEART
AB Individuals with metabolic syndrome (MS) show several metabolic abnormalities including insulin resistance, dyslipidaemia, and oxidative stress (OS). Diet is one of the factors influencing the development of MS, and current nutritional advice emphasises the benefits of fruit and vegetable consumption. Here, we assessed the effects of naturally occurring antioxidants, red wine polyphenols (RWPs), on MS and OS.
   Wistar rats (n = 20) weighing 200-220 g received a high-fat diet (HFD) for 2 months before they were divided into two groups that received either HFD only or HFD plus 50 mg/kg RWPs in their drinking water for an additional 2 months. A control group (n = 10) received a normal diet (ND) for 4 months.
   Rats receiving HFD increased body weight over 20 % throughout the duration of the study. They also showed increased blood levels of C-peptide, glucose, lipid peroxides, and oxidised proteins. In addition, the HFD increased OS in hepatic, pancreatic, and vascular tissues, as well as induced pancreatic islet cell hyperplasia and hepatic steatosis. Addition of RWPs to the HFD attenuated these effects on plasma and tissue OS and on islet cell hyperplasia. However, RWPs had no effect on blood glucose levels or hepatic steatosis.
   RWPs showed an antioxidant mechanism of action against MS. This result will inform future animal studies exploring the metabolic effects of RWPs in more detail. In addition, these findings support the use of antioxidants as adjunctive nutritional treatments for patients with diabetes.
C1 [Auberval, Nathalie; Dal, Stephanie; Maillard, Elisa; Bietiger, William; Peronet, Claude; Pinget, Michel; Sigrist, Severine] Univ Strasbourg, FMTS, Ctr Europeen Etud Diabet, UMR DIATHEC,EA 7294, Bld Rene Leriche, F-67200 Strasbourg, France.
   [Pinget, Michel; Schini-Kerth, Valerie] Univ Strasbourg, Fac Pharm, Pharmacol & Phys Chim, UMR CNRS 7175, F-67400 Illkirch Graffenstaden, France.
   [Pinget, Michel] HUS, Pole NUDE, Dept Endocrinol, Diabet,Malad,Metab, F-67000 Strasbourg, France.
C3 Universites de Strasbourg Etablissements Associes; Universite de
   Strasbourg; Universites de Strasbourg Etablissements Associes;
   Universite de Strasbourg; Centre National de la Recherche Scientifique
   (CNRS); CHU Strasbourg
RP Sigrist, S (corresponding author), Univ Strasbourg, FMTS, Ctr Europeen Etud Diabet, UMR DIATHEC,EA 7294, Bld Rene Leriche, F-67200 Strasbourg, France.
EM s.sigrist@ceed-diabete.org
FU foundation "Vaincre le Diabete"; ASDIA (Assistance Service Diabete)
FX The authors would like to express their gratitude to the foundation
   "Vaincre le Diabete" and ASDIA (Assistance Service Diabete) for funding
   this project.
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NR 42
TC 15
Z9 15
U1 1
U2 21
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1436-6207
EI 1436-6215
J9 EUR J NUTR
JI Eur. J. Nutr.
PD JUN
PY 2017
VL 56
IS 4
BP 1467
EP 1475
DI 10.1007/s00394-016-1192-2
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA EX7ZU
UT WOS:000403469100008
PM 26913853
DA 2025-06-11
ER

PT J
AU Hiasa, KI
   Takemoto, M
   Matsukawa, R
   Matoba, T
   Kuga, T
   Sunagawa, K
AF Hiasa, Ken-ichi
   Takemoto, Masao
   Matsukawa, Ryuichi
   Matoba, Tetsuya
   Kuga, Takeshi
   Sunagawa, Kenji
TI Chest Pain without Significant Coronary Stenosis after Implantation of
   Sirolimus-Eluting Stents
SO INTERNAL MEDICINE
LA English
DT Article
DE coronary intervention; exercise; coronary vasoconstriction; microvessel
   dysfunction
ID CARDIAC SYNDROME-X; ENDOTHELIAL DYSFUNCTION; ANGINA; HYPERSENSITIVITY;
   THROMBOSIS
AB We encountered a case of exercise-induced chest pain after the implantation of sirolimus-eluting stents (SESs). She had no history of previous chest pain, and an exercise stress test just after the implantation of the SESs was negative without any symptoms. However, six months after the implantation of the SESs, she began to experience frequent episodes of severe chest pain on effort in spite of there being no significant coronary stenosis. Interestingly, severe coronary vasoconstriction was induced by an intracoronary administration of acetylcholine, and exercise stress testing revealed positive findings with chest pain and ST-T segment depression on ECG. An intensive treatment with two types of calcium channel blockers could readily and completely abolish the exercise-induced chest pain and ST-T segment depression on the ECG. In view of these findings, we presumed that coronary microvessel dysfunction and/or exercise-induced coronary vasoconstriction leading to myocardial ischemia had appeared 6 months after the implantation of the SESs. Although the pathogenesis of this phenomenon could not be completely elucidated, the anatomical and functional abnormalities of the coronary arteries associated with the implantation of the SESs may have been one of the most important mechanisms.
C1 [Hiasa, Ken-ichi; Takemoto, Masao; Matsukawa, Ryuichi; Matoba, Tetsuya; Sunagawa, Kenji] Kyushu Univ Hosp, Dept Cardiovasc Med, Fukuoka 812, Japan.
   [Kuga, Takeshi] Mitsutake Hosp, Nagasaki, Japan.
C3 Kyushu University
RP Takemoto, M (corresponding author), Kyushu Univ Hosp, Dept Cardiovasc Med, Fukuoka 812, Japan.
EM matakemo@cardiol.med.kyushu-u.ac.jp
RI Matoba, Tetsuya/M-1920-2013
OI Matoba, Tetsuya/0000-0003-4563-304X
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NR 21
TC 3
Z9 4
U1 0
U2 1
PU JAPAN SOC INTERNAL MEDICINE
PI TOKYO
PA 34-3 3-CHOME HONGO BUNKYO-KU, TOKYO, 113, JAPAN
SN 0918-2918
EI 1349-7235
J9 INTERNAL MED
JI Intern. Med.
PY 2009
VL 48
IS 4
BP 213
EP 217
DI 10.2169/internalmedicine.48.1581
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 410SY
UT WOS:000263599800007
PM 19218771
DA 2025-06-11
ER

PT J
AU Nielsen, FH
AF Nielsen, Forrest H.
TI Dietary Magnesium and Chronic Disease
SO ADVANCES IN CHRONIC KIDNEY DISEASE
LA English
DT Article
DE Dietary magnesium deficiency; Inflammatory stress; Oxidative stress;
   C-reactive protein; Chronic disease risk
ID C-REACTIVE PROTEIN; CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; SERUM
   MAGNESIUM; VITAMIN-E; INFLAMMATORY RESPONSE; PROSPECTIVE COHORT;
   RECEPTOR BLOCKADE; STATUS INDICATORS; DEFICIENT RATS
AB Although official magnesium (Mg) dietary reference intakes are open to question, a significant number of adults likely have intakes that are in the range of 50%-99% of the requirement. This moderate or marginal (subclinical) deficient Mg intake generally is asymptomatic. Animal studies, however, indicate that moderate or subclinical Mg deficiency primes phagocytic cells for the release of proinflammatory cytokines leading to chronic inflammatory and oxidative stress. Human studies have found that dietary Mg is inversely related to serum or plasma C-reactive protein (CRP). Individuals with apparently deficient Mg intakes have an increased likelihood of serum or plasma CRP >= 3.0 mg/L, considered an indicator of chronic inflammatory stress that increases the risk for chronic disease. In addition, elevated serum or plasma CRP in individuals with chronic disease is decreased by Mg supplementation, which suggests that Mg decreases the risk for chronic disease. The importance of dietary Mg intake on the risk for chronic disease through affecting inflammatory and oxidative stress is supported by numerous meta-analyses and systematic reviews that have found dietary Mg is inversely associated with chronic diseases such hypertension, ischemic heart disease, stroke, metabolic syndrome, diabetes, and colorectal cancer. (C) 2017 by the National Kidney Foundation, Inc. All rights reserved.
C1 [Nielsen, Forrest H.] 3000 Belmont Rd, Grand Forks, ND 58201 USA.
RP Nielsen, FH (corresponding author), 3000 Belmont Rd, Grand Forks, ND 58201 USA.
EM FrostyNielsen@yahoo.com
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NR 69
TC 40
Z9 48
U1 0
U2 10
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 1548-5595
EI 1548-5609
J9 ADV CHRONIC KIDNEY D
JI Adv. Chronic Kidney Dis.
PD MAY
PY 2018
VL 25
IS 3
BP 230
EP 235
DI 10.1053/j.ackd.2017.11.005
PG 6
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA GH9PU
UT WOS:000434002100004
PM 29793661
DA 2025-06-11
ER

PT J
AU Coplan, JD
   Rozenboym, AV
   Fulton, SL
   Panthangi, V
   Tang, J
   Thiramangalakdi, L
   Perera, TD
   Liu, Y
   Kamran, H
   Owens, MJ
   Nemeroff, CB
   Rosenblum, LA
   Kral, JG
   Salciccioli, L
   Lazar, J
AF Coplan, Jeremy D.
   Rozenboym, Anna V.
   Fulton, Sasha L.
   Panthangi, Venkatesh
   Tang, Jean
   Thiramangalakdi, Lakshmi
   Perera, Tarique D.
   Liu, Yang
   Kamran, Haroon
   Owens, Michael J.
   Nemeroff, Charles B.
   Rosenblum, Leonard A.
   Kral, John G.
   Salciccioli, Louis
   Lazar, Jason
TI Reduced left ventricular dimension and function following early life
   stress: A thrifty phenotype hypothesis engendering risk for mood and
   anxiety disorders
SO NEUROBIOLOGY OF STRESS
LA English
DT Article
ID CORTICOTROPIN-RELEASING-FACTOR; ADVERSE CHILDHOOD EXPERIENCES; VARIABLE
   FORAGING DEMAND; BONNET MACAQUES; CARDIOVASCULAR-DISEASE; PSYCHOSOCIAL
   DWARFISM; METABOLIC SYNDROME; NONHUMAN-PRIMATES; EPIGENETIC MECHANISMS;
   RHESUS-MONKEYS
AB Background: Early life stress (ELS) in macaques in the form of insecure maternal attachment putatively induces epigenetic adaptations resulting in a "thrifty phenotype" throughout the life cycle. For instance, ELS induces persistent increases in insulin resistance, hippocampal and corpus callosum atrophy and reduced "behavioral plasticity", which, taken together, engenders an increased risk for mood and anxiety disorders in humans but also a putative sparing of calories. Herein, we test the hypothesis whether a thrifty phenotype induced by ELS is peripherally evident as hypotrophy of cardiac structure and function, raising the possibility that certain mood disorders may represent maladaptive physiological and central thrift adaptations.
   Methods: 14 adult bonnet macaques (6 males) exposed to the maternal variable foraging demand (VFD) model of ELS were compared to 20 non-VFD adult subjects (6 males). Left ventricle end-diastolic dimension (LVEDD), Left ventricle end-systolic dimension (LVESD) and stroke volume (SV) were calculated using echocardiography. Blood pressure and heart rate were measured only in females. Previously obtained neurobehavioral correlates available only in males were analyzed in the context of cardiac parameters.
   Results: Reduced LVESD (p < 0.05) was observed when controlled for age, sex, body weight and crown-rump length whereas ejection fraction (EF) (p = 0.037) was greater in VFD-reared versus non-VFD subjects. Pulse pressure was lower in VFD versus non-VFD females (p < 0.05). Male timidity in response to a human intruder was associated with reduced LVEDD (p < 0.05).
   Conclusions: ELS is associated with both structural and functional reductions of left ventricular measures, potentially implying a body-wide thrifty phenotype. Parallel "thrift" adaptations may occur in key brain areas following ELS and may play an unexplored role in mood and anxiety disorder susceptibility. (c) 2017 The Authors. Published by Elsevier Inc.
C1 [Coplan, Jeremy D.; Panthangi, Venkatesh; Rosenblum, Leonard A.] SUNY Downstate, Dept Psychiat & Behav Sci, Brooklyn, NY USA.
   [Rozenboym, Anna V.] Kinsborough Community Coll, Brooklyn, NY USA.
   [Fulton, Sasha L.; Tang, Jean; Thiramangalakdi, Lakshmi; Perera, Tarique D.] New York State Psychiat Inst & Hosp, Dept Psychiat, New York, NY 10032 USA.
   [Liu, Yang; Kamran, Haroon; Salciccioli, Louis; Lazar, Jason] SUNY Downstate, Div Cardiol, Dept Med, Brooklyn, NY USA.
   [Owens, Michael J.] Emory Univ, Sch Med, Dept Psychiat & Behav Sci, Emory, GA USA.
   [Nemeroff, Charles B.] Univ Miami Hlth Syst, Dept Psychiat & Behav Sci, Miami, NY USA.
   [Kral, John G.] SUNY Downstate, Dept Internal Med, Brooklyn, NY USA.
   [Kral, John G.] SUNY Downstate, Dept Surg, Brooklyn, NY USA.
C3 State University of New York (SUNY) System; SUNY Downstate Health
   Sciences University; New York State Psychiatry Institute; State
   University of New York (SUNY) System; SUNY Downstate Health Sciences
   University; Emory University; State University of New York (SUNY)
   System; SUNY Downstate Health Sciences University; State University of
   New York (SUNY) System; SUNY Downstate Health Sciences University
RP Coplan, JD (corresponding author), Suny Downstate Med Ctr, 450 Clarkson Ave,Box 1199, Brooklyn, NY 11203 USA.
EM Jeremy.Coplan@downstate.edu
RI Owens, Michael/G-5191-2012; Nemeroff, Charles/AEU-9195-2022
OI Tang, Jean Ee/0000-0001-9471-7456; Fulton, Sasha/0000-0003-3626-7412;
   Nemeroff, Charles/0000-0001-7867-1160
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NR 57
TC 6
Z9 6
U1 0
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 2352-2895
J9 NEUROBIOL STRESS
JI Neurobiol. Stress
PD FEB
PY 2018
VL 8
BP 202
EP 210
DI 10.1016/j.ynstr.2017.01.001
PG 9
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA GH7MA
UT WOS:000433627600019
PM 29888314
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Rajagopalan, KS
   Kazeminia, S
   Glasstetter, LM
   Farahani, RA
   Zhu, XY
   Tang, H
   Jordan, KL
   Chade, AR
   Lerman, A
   Lerman, LO
   Eirin, A
AF Rajagopalan, Kamalnath S.
   Kazeminia, Sara
   Glasstetter, Logan M.
   Farahani, Rahele A.
   Zhu, Xiang-Yang
   Tang, Hui
   Jordan, Kyra L.
   Chade, Alejandro R.
   Lerman, Amir
   Lerman, Lilach O.
   Eirin, Alfonso
TI Metabolic Syndrome Induces Epigenetic Alterations in
   Mitochondria-Related Genes in Swine Mesenchymal Stem Cells
SO CELLS
LA English
DT Article
DE mesenchymal stem cells; metabolic syndrome; mitochondria; epigenetics;
   MeDIP-seq; DNA methylation
ID OXIDATIVE STRESS; DNA DEMETHYLATION; STROMAL CELLS; VITAMIN-C;
   5-METHYLCYTOSINE; MUTATIONS; PATHOPHYSIOLOGY; INFLAMMATION; METHYLATION;
   DYSFUNCTION
AB Autologous mesenchymal stem/stromal cells (MSCs) have demonstrated important therapeutic effects in several diseases. Cardiovascular risk factors may impair MSC mitochondrial structure and function, but the underlying mechanisms remain unknown. We hypothesized that metabolic syndrome (MetS) induces epigenetic alterations in mitochondria-related genes in swine MSCs. Pigs were fed a Lean or MetS diet (n = 6 each) for 16 weeks. MSCs were collected from subcutaneous abdominal fat, and DNA hydroxymethylation (5 hmC) profiles of mitochondria related genes (MitoCarta-2.0) were analyzed by hydroxymethylated DNA immunoprecipitation and next-generation sequencing (hMeDIP-seq) in Lean-and MetS-MSCs untreated or treated with the epigenetic modulator vitamin (Vit)-C (n = 3 each). Functional analysis of genes with differential 5 hmC regions was performed using DAVID6.8. Mitochondrial structure (electron microscopy), oxidative stress, and membrane potential were assessed. hMeDIP-seq identified 172 peaks (associated with 103 mitochondrial genes) with higher and 416 peaks (associated with 165 mitochondrial genes) with lower 5 hmC levels in MetS-MSCs versus Lean-MSCs (=2-fold, p < 0.05). Genes with higher 5 hmC levels in MetS + MSCs were primarily implicated in fatty acid metabolism, whereas those with lower 5 hmC levels were associated with electron transport chain activity. Vit-C increased 5 hmC levels in mitochondrial antioxidant genes, improved mitochondrial structure and membrane potential, and decreased oxidative stress. MetS alters 5 hmC levels of mitochondria-related genes in swine MSCs. Vit-C modulated 5 hmC levels in these genes and preserved mitochondrial structure and function in MetS-MSCs. These observations may contribute to development of strategies to overcome the deleterious effects of MetS on MSCs.
C1 [Rajagopalan, Kamalnath S.; Kazeminia, Sara; Glasstetter, Logan M.; Zhu, Xiang-Yang; Tang, Hui; Jordan, Kyra L.; Lerman, Lilach O.; Eirin, Alfonso] Mayo Clin, Div Nephrol & Hypertens, Rochester, MN 55905 USA.
   [Farahani, Rahele A.] Mayo Clin, Div Endocrinol Diabet Metab & Nutr, Rochester, MN 55905 USA.
   [Chade, Alejandro R.] Univ Missouri Columbia, Dept Med Pharmacol & Physiol, Columbia, MO 65211 USA.
   [Chade, Alejandro R.] Univ Missouri Columbia, Dept Med, Columbia, MO 65211 USA.
   [Lerman, Amir; Lerman, Lilach O.; Eirin, Alfonso] Mayo Clin, Dept Cardiovasc Dis, Rochester, MN 55905 USA.
C3 Mayo Clinic; Mayo Clinic; University of Missouri System; University of
   Missouri Columbia; University of Missouri System; University of Missouri
   Columbia; Mayo Clinic
RP Eirin, A (corresponding author), Mayo Clin, Div Nephrol & Hypertens, Rochester, MN 55905 USA.; Eirin, A (corresponding author), Mayo Clin, Dept Cardiovasc Dis, Rochester, MN 55905 USA.
EM eirinmassat.alfonso@mayo.edu
RI Lerman, Lilach/M-4962-2017; Eirin, Alfonso/N-9873-2013
OI kazeminia, sara/0000-0002-2621-9962
FU National Institutes of Health [R01HL158691, HL095638, DK120292,
   DK129240]; Regenerative Medicine Minnesota (RMM) [091620 DS 004]
FX This work was supported by the National Institutes of Health grants
   R01HL158691, HL095638, DK120292, and DK129240, and Regenerative Medicine
   Minnesota (RMM 091620 DS 004).
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NR 80
TC 3
Z9 3
U1 0
U2 3
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2073-4409
J9 CELLS-BASEL
JI Cells
PD APR 27
PY 2023
VL 12
IS 9
AR 1274
DI 10.3390/cells12091274
PG 19
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA G2FV2
UT WOS:000987387900001
PM 37174674
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Rogulj, D
   El Aklouk, I
   Konjevoda, P
   Ljubic, S
   Okanovic, MP
   Barbir, A
   Luburic, M
   Radman, M
   Budinski, N
   Lovrencic, MV
AF Rogulj, Dinko
   El Aklouk, Ismail
   Konjevoda, Pasko
   Ljubic, Spomenka
   Okanovic, Mirjana Pibernik
   Barbir, Ante
   Luburic, Marijana
   Radman, Maja
   Budinski, Ninoslav
   Lovrencic, Marijana Vucic
TI Age-dependent systemic DNA damage in early Type 2 Diabetes mellitus
SO ACTA BIOCHIMICA POLONICA
LA English
DT Article
DE metabolic syndrome; type 2 diabetes mellitus; DNA damage; urinary 8-OHdG
ID OXIDATIVE STRESS; METABOLIC SYNDROME; URIC-ACID; BIOMARKER; LEVEL
AB Oxidative stress, capable of eliciting damage to various biomolecules including DNA, is a recognized component of diabetes mellitus and its complications. Metabolic syndrome (MetS) is associated with the development of type 2 diabetes mellitus (T2DM), as well as other unfavorable outcomes. The aim of this study was to elucidate the role of oxidative stress in the development of T2DM, by investigating association of oxidative DNA damage with metabolic parameters in subjects with MetS and early T2DM. Selected anthropometric and biochemical parameters of MetS, inflammation and oxidative DNA damage: body mass index (BMI), fatty liver index (FLI), waist circumference (WC), total cholesterol, HDL and LDL-cholesterol, gamma-glutamyl transpeptidase (GGT), uric acid, C-reactive protein (CRP), total leukocyte/neutrophil count, and urinary 8-hidroxy-deoxyguanosine (u-8-OHdG) were assessed in male subjects with MetS and both younger (<= 55 years) and older (> 55 years) subjects with T2DM of short duration without complications. BMI, FLI, WC, total and LDL-cholesterol and uric acid were higher, while the u-8-OHdG was lower in MetS group, when compared to older T2DM subjects. None of these parameters were different neither between MetS and younger T2DM, nor between two sub-groups of subjects with T2DM. Values of CRP, HDL-cholesterol, triglycerides, GGT, leukocytes and neutrophils were not different between all examined groups of subjects. Higher 8-OHdG in older subjects with T2DM suggests that both aging process and diabetes could contribute to the development of DNA damage. Oxidative DNA damage cannot serve as an universal early marker of T2DM.
C1 [Rogulj, Dinko] Gen Hosp Brezice, Dept Internal Med, Brezice, Slovenia.
   [El Aklouk, Ismail] Gen Hosp Varazdin, Dept Extending & Palliat Care Novi Marof, Varazhdin, Croatia.
   [Konjevoda, Pasko] Inst Rudjer Boskov, NMR Ctr, Zagreb, Croatia.
   [Ljubic, Spomenka; Okanovic, Mirjana Pibernik] Univ Hosp Merkur, Vuk Vrhovac Univ Clin Diabet Endocrinol & Metab D, Zagreb, Croatia.
   [Barbir, Ante; Luburic, Marijana] Polyclin Sunce, Zagreb, Croatia.
   [Radman, Maja] Univ Hosp Ctr Split, Dept Internal Med, Split, Croatia.
   [Budinski, Ninoslav] Univ Hosp Sveti Duh, Dept Internal Med, Zagreb, Croatia.
   [Lovrencic, Marijana Vucic] Univ Hosp Merkur, Dept Lab Med, Sci Res Unit, Zagreb, Croatia.
C3 University of Split
RP Rogulj, D (corresponding author), Gen Hosp Brezice, Dept Internal Med, Brezice, Slovenia.
EM Dinko.Rogulj@xnet.hr
RI Radman, Maja/H-2891-2017
OI Konjevoda, Pasko/0000-0003-3966-1132; Vucic Lovrencic,
   Marijana/0000-0001-7365-0627
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NR 29
TC 9
Z9 11
U1 0
U2 7
PU ACTA BIOCHIMICA POLONICA
PI WARSAW
PA PASTEURA 3, 02-093 WARSAW, POLAND
SN 0001-527X
EI 1734-154X
J9 ACTA BIOCHIM POL
JI Acta Biochim. Pol.
PY 2017
VL 64
IS 2
BP 233
EP 238
DI 10.18388/abp.2016_1313
PG 6
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA FH6TX
UT WOS:000411312700006
PM 28350403
OA gold
DA 2025-06-11
ER

PT J
AU Sánchez-Navarro, A
   Martínez-Rojas, MA
   Caldiño-Bohn, RI
   Pérez-Villalva, R
   Zambrano, E
   Castro-Rodríguez, DC
   Bobadilla, NA
AF Sanchez-Navarro, Andrea
   Martinez-Rojas, Miguel Angel
   Caldino-Bohn, Rebecca I.
   Perez-Villalva, Rosalba
   Zambrano, Elena
   Castro-Rodriguez, Diana C.
   Bobadilla, Norma A.
TI Early triggers of moderately high-fat diet-induced kidney damage
SO PHYSIOLOGICAL REPORTS
LA English
DT Article
DE ER-stress; glomerular hypertrophy; mitochondrial dynamics disruption;
   renal inflammation
ID ENDOPLASMIC-RETICULUM STRESS; OXIDATIVE STRESS; METABOLIC SYNDROME; ER
   STRESS; OBESITY; DISEASE; BIOMARKER; INJURY; GLOMERULOPATHY;
   INFLAMMATION
AB Most of the obesity murine models inducing renal injury use calorie-enriched foods, where fat represents 60% of the total caloric supply, however, this strategy doubles the standard proportion of fat ingestion in obese patients. Therefore, it is crucial to study the impact of a high-fat intake on kidney physiology that resembles common obesity in humans to understand the trigger mechanisms of the long-term consequences of overweight and obesity. In this study, we analyzed whether chronic feeding with a moderately high fat diet (MHFD) representing 45% of total calories, may induce kidney function and structural injury compared to C57BL/6 mice fed a control diet. After 14 weeks, MHFD induced significant mice obesity. At the functional level, obese mice showed signs of kidney injury characterized by increased albuminuria/creatinine ratio and higher excretion of urinary biomarkers of kidney damage. While, at the structural level, glomerular hypertrophy was observed. Although, we did not detect renal fibrosis, the obese mice exhibited a significant elevation of Tgfb1 mRNA levels. Kidney damage caused by the exposure to MHFD was associated with greater oxidative stress, renal inflammation, higher endoplasmic reticulum (ER)-stress, and disruption of mitochondrial dynamics. In summary, our data demonstrate that obesity induced by a milder fat content diet is enough to establish renal injury, where oxidative stress, inflammation, ER-stress, and mitochondrial damage take relevance, pointing out the importance of opportune interventions to avoid the long-term consequences associated with obesity and metabolic syndrome.
C1 [Sanchez-Navarro, Andrea; Martinez-Rojas, Miguel Angel; Caldino-Bohn, Rebecca I.; Bobadilla, Norma A.] Univ Nacl Autonoma Mexico, Inst Invest Biomed, Mol Physiol Unit, Mexico City, DF, Mexico.
   [Sanchez-Navarro, Andrea; Martinez-Rojas, Miguel Angel; Caldino-Bohn, Rebecca I.; Perez-Villalva, Rosalba; Bobadilla, Norma A.] Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Nephrol, Salvador, BA, Mexico.
   [Zambrano, Elena; Castro-Rodriguez, Diana C.] Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Biol Reprod, Salvador, BA, Mexico.
   [Castro-Rodriguez, Diana C.] CONACyT Catedras, Mexico City, DF, Mexico.
C3 Universidad Nacional Autonoma de Mexico; Instituto Nacional de Ciencias
   Medicas y Nutricion Salvador Zubiran - Mexico; Instituto Nacional de
   Ciencias Medicas y Nutricion Salvador Zubiran - Mexico
RP Bobadilla, NA (corresponding author), Unidad Fisiol Mol, Vasco Quiroga 15,Tlalpan, Mexico City 14080, DF, Mexico.
EM nab@biomedicas.unam.mx
RI Castro-Rodríguez, Diana/ACR-4154-2022; Martinez-Rojas, Miguel
   Angel/CAF-9647-2022; Sanchez-Navarro, Andrea/IUN-5828-2023
OI Zambrano, Elena/0000-0002-0362-9117; Sanchez-Navarro,
   Andrea/0000-0002-5625-323X; Martinez-Rojas, Miguel
   Angel/0000-0003-1060-5567; Diana Catalina,
   Castro-Rodriguez/0000-0003-0608-1799; Bobadilla, Norma
   A/0000-0002-3153-9151
FU Mexican Council of Science and Technology (CONACyT) [235855,
   000000000300151, A1-S-8715]; Universidad Nacional Autonoma de Mexico
   [IN223915, IN201619]; Consejo Nacional de Ciencia y
   Tecnologia-Secretaria de Educacion Publica (CONACyT-SEP) [287912];
   CONACYT [607517]
FX This project was supported by grants from the Mexican Council of Science
   and Technology (CONACyT) (235855, 000000000300151, and A1-S-8715 to
   NAB), from the Universidad Nacional Autonoma de Mexico (IN223915 and
   IN201619 to NAB) and from Consejo Nacional de Ciencia y
   Tecnologia-Secretaria de Educacion Publica (CONACyT-SEP) (287912 to EZ).
   This study was performed in partial fulfillment of the requirements for
   the PhD degree, Andrea Sanchez--Navarro is a doctoral student from
   Programa de Doctorado en Ciencias Biomedicas, Universidad Nacional
   Autonoma de Mexico (UNAM) and received a fellowship 607517 from CONACYT.
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NR 70
TC 5
Z9 6
U1 0
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2051-817X
J9 PHYSIOL REP
JI PHYSIOL. REP.
PD JUL
PY 2021
VL 9
IS 14
AR e14937
DI 10.14814/phy2.14937
PG 13
WC Physiology
WE Emerging Sources Citation Index (ESCI)
SC Physiology
GA TR4GP
UT WOS:000678925100004
PM 34291592
OA Green Published
DA 2025-06-11
ER

PT J
AU Ayán-Pérez, C
   Carballo-Afonso, R
   Bueno-Russo, R
   González-Devesa, D
AF Ayan-Perez, Carlos
   Carballo-Afonso, Rocio
   Bueno-Russo, Rodrigo
   Gonzalez-Devesa, Daniel
TI Is Physical Exercise Beneficial for People with Primary Sjögren's
   Syndrome? Findings from a Systematic Review
SO APPLIED SCIENCES-BASEL
LA English
DT Review
DE fatigue; exercise; quality of life; metabolic syndrome; physical
   activity; sleep; anxiety; depression
ID PRIMARY SJOGRENS-SYNDROME; QUALITY-OF-LIFE; FATIGUE; CAPACITY; DISEASES;
   DATABASE; HEALTH; PEDRO; WOMEN
AB Background: The aim of the study was to identify and critically evaluate the best available evidence on the impact of physical exercise on patients with primary Sj & ouml;gren's syndrome. Methods: Studies were searched in four electronic databases (PubMed, Web of Science, Scopus, and SportDiscus) from their inception up to September 2024. The methodological quality of the included studies was assessed using the 10-point Physiotherapy Evidence Database (PEDro) scale and the Methodological Index for Non-Randomized Studies (MINORS). Results: A total of four randomized controlled trials and one comparative study were analyzed. The training programs evaluated varied in duration, ranging from 12 to 28 weeks. Exercise was found to have a positive intra-group impact on fatigue, quality of life, and functional capacity. However, exercise does not demonstrate superior effects compared to standard treatment for improving quality of life and disease impact. Conclusions: It is essential to increase the number of studies involving individuals with primary Sj & ouml;gren's syndrome across various exercise conditions to more comprehensively evaluate the potential benefits.
C1 [Ayan-Perez, Carlos; Carballo-Afonso, Rocio; Gonzalez-Devesa, Daniel] Galicia Sur Hlth Res Inst IIS Galicia Sur, Well Move Res Grp, SERGAS UVIGO, Vigo 36310, Spain.
   [Ayan-Perez, Carlos; Carballo-Afonso, Rocio] Univ Vigo, Dept Didact Especiais, Vigo 36310, Spain.
   [Bueno-Russo, Rodrigo; Gonzalez-Devesa, Daniel] Univ Catolica Avila, Grp Invest Actividad Fis Educ & Salud GIAFES, Avila 05005, Spain.
C3 Universidade de Vigo
RP González-Devesa, D (corresponding author), Galicia Sur Hlth Res Inst IIS Galicia Sur, Well Move Res Grp, SERGAS UVIGO, Vigo 36310, Spain.; González-Devesa, D (corresponding author), Univ Catolica Avila, Grp Invest Actividad Fis Educ & Salud GIAFES, Avila 05005, Spain.
EM cayan@uvigo.es; rociocarballo@uvigo.gal; rodrigo.bueno@ucavila.es;
   daniel.gonzalez@ucavila.es
RI Milá, Zacarias/GRJ-4067-2022; González Devesa, Daniel/IVV-4958-2023;
   AyÃ¡n, Carlos/Z-3105-2019; Carballo Afonso, María Rocío/JRY-6234-2023
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NR 67
TC 0
Z9 0
U1 5
U2 5
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2076-3417
J9 APPL SCI-BASEL
JI Appl. Sci.-Basel
PD FEB
PY 2025
VL 15
IS 3
AR 1455
DI 10.3390/app15031455
PG 17
WC Chemistry, Multidisciplinary; Engineering, Multidisciplinary; Materials
   Science, Multidisciplinary; Physics, Applied
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Engineering; Materials Science; Physics
GA W4S7L
UT WOS:001418499100001
OA gold
DA 2025-06-11
ER

PT J
AU Mahdavifard, S
   Dehghani, R
   Jeddi, F
   Najafzadeh, N
AF Mahdavifard, Sina
   Dehghani, Razieh
   Jeddi, Farhad
   Najafzadeh, Nowruz
TI Thiamine reduced metabolic syndrome symptoms in rats via down-regulation
   of hepatic nuclear factor-kβ and induction activity of glyoxalase-I
SO IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
LA English
DT Article
DE Glycation; Glyoxalase-I; Metabolic syndrome; Nuclear factor-k&#946;
   Thiamine
ID OXIDATION PROTEIN PRODUCTS; DEFICIENCY; GLYCATION; GLUCOSE; PREVENTS;
   STRESS; IMPACT; LIPIDS; RISK; LDL
AB Objective(s): Metabolic syndrome (MS) is a cause of death worldwide. The hepatic nuclear factor NFk beta (NF-k beta) is the cardinal player of hepatic homeostasis, insulin sensitivity, and lipid metabolism. Thus, we investigated the effect of thiamine on hepatic gene expression of NF-k beta and its levels of activators in MS rats.
   Materials and Methods: Male Wistar rats were randomly divided into 4 equal groups (ten rats in each group): normal, MS, and two alike groups under thiamine treatment. MS was induced in rats with a high sucrose solution (40 % in drinking water) for 4 months. Treated groups of rats received 0.18 % of thiamine daily in drinking water. Hematoxylin-Eosin stains were employed to determine the histopathological changes of the liver. Metabolic profile, glycation products, oxidative stress, inflammatory markers, the activity of glyoxalase-I, as well as NF-k beta hepatic expression of all rat groups, were determined.
   Results: Acute hepatitis was not observed in the livers of the thiamine treated MS rats. Besides, the treatment showed an advantageous effect on glucose, lipid metabolism, and body weight via down regulation of hepatic NF-k beta and induction of glyoxalase system activity. Furthermore, the treatment decreased diverse glycation, oxidative stress, and inflammatory markers (P>0.001).
   Conclusion: Thiamine decreased body weight and improved metabolism and activity of glyoxalase-I in MS rats with anti-glycation, antioxidant, and anti-inflammatory activities. Further, the treatment had a hepato-protective effect via reduction of NF-k beta signaling.
C1 [Mahdavifard, Sina; Dehghani, Razieh] Ardabil Univ Med Sci, Dept Clin Biochem, Ardebil, Iran.
   [Jeddi, Farhad] Ardabil Univ Med Sci, Sch Med, Dept Genet & Pathol, Ardebil, Iran.
   [Najafzadeh, Nowruz] Ardabil Univ Med Sci, Sch Med, Dept Anat Sci, Res Lab Embryol & Stem Cells, Ardebil, Iran.
C3 Ardabil University of Medical Sciences; Ardabil University of Medical
   Sciences; Ardabil University of Medical Sciences
RP Mahdavifard, S (corresponding author), Ardabil Univ Med Sci, Dept Clin Biochem, Ardebil, Iran.
EM s.mahdavifard@Arums.ac.ir
RI Dehghani, Razieh/S-9042-2018; Mahdavifard, Sina/A-1038-2018; jeddi,
   farhad/I-9707-2018; Najafzadeh, Nowruz/C-7429-2014
FU Ardabil University of Medical Sciences, Ardabil, Iran
FX The results presented in this paper were part of a student thesis. The
   authors are thankful to Ardabil University of Medical Sciences, Ardabil,
   Iran for financial support.
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NR 54
TC 8
Z9 8
U1 0
U2 5
PU MASHHAD UNIV MED SCIENCES
PI MASHHAD
PA VICE-CHANCELLOR FOR RES CTR OFF IJBMS, DANESHGAH ST, PO BOX 9138813944 -
   445, MASHHAD, 00000, IRAN
SN 2008-3866
EI 2008-3874
J9 IRAN J BASIC MED SCI
JI Iran. J. Basic Med. Sci.
PD MAR
PY 2021
VL 24
IS 3
BP 293
EP 299
DI 10.22038/ijbms.2021.53707.12086
PG 7
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA QP2RC
UT WOS:000623684900004
PM 33995940
DA 2025-06-11
ER

PT J
AU Ferretti, F
   Pozza, A
   Bossini, L
   Del Matto, L
   Desantis, S
   Olivola, M
   Gualtieri, G
   Coluccia, A
   Fagiolini, A
AF Ferretti, Fabio
   Pozza, Andrea
   Bossini, Letizia
   Del Matto, Laura
   Desantis, Serena
   Olivola, Miriam
   Gualtieri, Giacomo
   Coluccia, Anna
   Fagiolini, Andrea
TI A comparison of physical comorbidities in patients with posttraumatic
   stress disorder developed after a terrorist attack or other traumatic
   event
SO JOURNAL OF NEUROSCIENCE RESEARCH
LA English
DT Article
DE cardiovascular disease; metabolism disease; neoplasm; physical
   comorbidity; posttraumatic stress disorder; terroristic attacks
ID MILITARY SERVICE MEMBERS; METABOLIC SYNDROME; DOUBLE-BLIND; SEPTEMBER
   11; LIFE EVENTS; RISK; SYMPTOMS; CANCER; PTSD; HYPERTENSION
AB No study investigated whether the presence of specific medical comorbidities is associated with the type of traumatic event, in particular with terrorist attack (TA). In a group of subjects with posttraumatic stress disorder (PTSD), the current study investigated the association between the types of traumatic event (TA vs. other traumatic event [OTE]) and medical comorbidities, controlling for sex and PTSD duration. The Mini International Neuropsychiatric Interview, the Clinician-Administered PTSD Scale, and the Davidson Trauma Scale were administered to 84 subjects diagnosed with PTSD. Thirty-nine were victims of TA and 45 victims of OTE. TA was associated with higher prevalence of neoplasms (beta = 2.60, p = 0.02). Females were more protected than males from circulatory system comorbidities (beta = 1.47, p = 0.04), while PTSD duration was associated with higher prevalence of such comorbidities (beta = 0.005, p = 0.01). Females showed a higher prevalence of neoplasms than males (beta = 2.50, p = 0.02). Female sex was protective against metabolic syndrome (beta = -1.79, p = 0.02). Patients with PTSD due to TA and female patients should be considered for their higher prevalence of neoplasms, while male patients and those with higher symptom duration should be monitored for circulatory disease and metabolic syndrome. Symptom duration might be associated with circulatory and metabolic disease. Implications for tailored and timely psychopharmacological and psychotherapeutic intervention for PTSD are discussed focusing on these specific medical comorbidities.
C1 [Ferretti, Fabio; Pozza, Andrea; Gualtieri, Giacomo; Coluccia, Anna] Santa Maria Scotte Univ Hosp, Dept Med Sci Surg & Neurosci, Viale Mario Bracci 16, I-53100 Siena, Italy.
   [Bossini, Letizia; Del Matto, Laura; Desantis, Serena; Olivola, Miriam; Fagiolini, Andrea] Univ Siena, Sch Med, Dept Mol Med, Siena, Italy.
   [Bossini, Letizia; Del Matto, Laura; Desantis, Serena; Olivola, Miriam; Fagiolini, Andrea] Univ Siena, Med Ctr AOUS, Dept Mental Hlth, Siena, Italy.
C3 University of Siena; University Hospital of Siena; University of Siena;
   University of Siena; University Hospital of Siena
RP Pozza, A (corresponding author), Santa Maria Scotte Univ Hosp, Dept Med Sci Surg & Neurosci, Viale Mario Bracci 16, I-53100 Siena, Italy.
EM andreapozza7@gmail.com
RI Pozza, Andrea/W-7297-2019; Ferretti, Fabio/AAJ-2200-2020; Olivola,
   Miriam/AAH-9667-2021
OI Gualtieri, Giacomo/0009-0004-1008-9915; Ferretti,
   Fabio/0000-0001-8897-0965; Olivola, Miriam/0000-0003-0914-0539
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NR 57
TC 4
Z9 4
U1 1
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0360-4012
EI 1097-4547
J9 J NEUROSCI RES
JI J. Neurosci. Res.
PD MAY
PY 2019
VL 97
IS 5
BP 543
EP 553
DI 10.1002/jnr.24373
PG 11
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology
GA HP7TA
UT WOS:000461891200003
PM 30623488
DA 2025-06-11
ER

PT J
AU Guzik, P
   Rogacka, D
   Tarchalski, J
   Minczykowski, A
   Balihski, M
   Wykrqtowicz, A
   Wysocki, H
AF Guzik, Przemyslaw
   Rogacka, Dorota
   Tarchalski, Janusz
   Minczykowski, Andrzej
   Balihski, Marek
   Wykrqtowicz, Andrzej
   Wysocki, Henryk
TI Comparison of the exercise treadmill test and 24-hour ECG Holter
   monitoring in patients with syndrome X or coronary atherosclerosis
SO KARDIOLOGIA POLSKA
LA English
DT Article
DE syndrome X; coronary artery disease; exercise test; ECG Holter
   monitoring
ID LEFT-VENTRICULAR FUNCTION; CARDIAC SYNDROME-X; CHEST-PAIN;
   MYOCARDIAL-ISCHEMIA; ANGINA-PECTORIS; ADENOSINE; VASODILATION;
   PERCEPTION; BRAIN; WOMEN
AB Background: Typical chest pain and ECG changes suggest the presence of myocardial ischaemia in cardiac syndrome X (SX) patients and resemble the symptoms observed in subjects with atherosclerotic coronary artery disease (CAD),
   Aim: To compare the results of exercise treadmill tests (ETT), 24-hour ECG recordings and echocardiography in SX and CAD patients without previous myocardial infarction with the presence of significant lumen stenosis in one (CA1), two (CA2) or three (CA3) coronary arteries.
   Methods: Two hundred six patients were included in the study: 43 SX (28 female), 49 CA1 (11 female), 51 CA2 (7 female) and 63 CA3 patients (8 female) all of whom underwent ETT according to the Bruce protocol, 24-hour ECG recordings and echocardiography.
   Results: SX patients had median ST-segment depression during ETT comparable to that in CA1 and CA2 patients but significantly less than the CA3 subjects (p=0.024). Median time to ST depression of at least 1 mm, as well as median time of exercise, was significantly longer in SX individuals than in all CAD patients. The post-exercise recovery time of ST-segment changes was significantly longer in SX patients than in the CA1 group (p=0.006), comparable to that in CA2 subjects and shorter than that in CA3 individuals (p=0.003). Both the maximal ST-segment depression and the duration of significant ST-segment depression in Holter ECG recordings were significantly higher in SX patients than in CA1 subjects, were comparable to the values observed in the CA2 group and significantly lower than in CA3 individuals. The heart rate variability parameters (SDNN and pNN50) were significantly higher in SX patients than in CAD subjects. Patients with SX had a significantly thinner interventricular septum and smaller left ventricular end-diastolic cavity dimension than individuals from the CA1, CA2 and CA3 groups. There were no significant differences in the left ventricular ejection fraction or the thickness of the left ventricular posterior wall between SX patients and CAD patients.
   Conclusions: Analysis of the ST segment in SX patients suggests the presence of advanced CAD. However, SX patients have better heart rate variability and exercise performance than patients with CAD.
C1 [Guzik, Przemyslaw; Rogacka, Dorota; Minczykowski, Andrzej; Balihski, Marek; Wykrqtowicz, Andrzej; Wysocki, Henryk] Poznan Univ Med Sci, Intens Therapy & Internal Dis, Dept Cardiol, PL-60355 Poznan, Poland.
   [Tarchalski, Janusz] Card Dept Muncipal Hosp, Kalisz, Poland.
C3 Poznan University of Medical Sciences
RP Guzik, P (corresponding author), Poznan Univ Med Sci, Intens Therapy & Internal Dis, Dept Cardiol, PL-60355 Poznan, Poland.
EM pguzik@ptkardio.pl
OI Wykretowicz, Andrzej/0000-0001-9545-1629; Minczykowski,
   Andrzej/0000-0003-4179-2115; Guzik, Przemyslaw/0000-0001-9052-5027
CR [Anonymous], CHOUS ELECTROCARDIOG
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NR 33
TC 6
Z9 6
U1 0
U2 1
PU POLISH CARDIAC SOC-POLSKIE TOWARZYSTWO KARDIOLOGICZNE
PI WARSZAWA
PA UL STAWKI 3 A LOK 1-2, WARSZAWA, POLAND
SN 0022-9032
EI 1897-4279
J9 KARDIOL POL
JI Kardiol. Pol.
PD MAR
PY 2007
VL 65
IS 3
BP 262
EP 271
PG 10
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 281II
UT WOS:000254489700005
PM 17436154
DA 2025-06-11
ER

PT J
AU Fulp, A
   Zhang, YN
   Bortoff, K
   Seltzman, H
   Snyder, R
   Wiethe, R
   Amato, G
   Maitra, R
AF Fulp, Alan
   Zhang, Yanan
   Bortoff, Katherine
   Seltzman, Herbert
   Snyder, Rodney
   Wiethe, Robert
   Amato, George
   Maitra, Rangan
TI Pyrazole antagonists of the CB1 receptor with reduced brain penetration
SO BIOORGANIC & MEDICINAL CHEMISTRY
LA English
DT Article
DE CB1; Cannabinoid; Peripheral; Antagonist; Rimonabant; Pyrazole; CB2;
   MDCK; PAMPA; Blood brain barrier
ID CEREBRAL BLOOD-VOLUME; ENDOCANNABINOID SYSTEM; PAMPA-MODELS; DESIGN
AB Type 1 cannabinoid receptor (CB1) antagonists might be useful for treating obesity, liver disease, metabolic syndrome, and dyslipidemias. Unfortunately, inhibition of CB1 in the central nervous system (CNS) produces adverse effects, including depression, anxiety and suicidal ideation in some patients, which led to withdrawal of the pyrazole inverse agonist rimonabant (SR141716A) from European markets. Efforts are underway to produce peripherally selective CB1 antagonists to circumvent CNS-associated adverse effects. In this study, novel analogs of rimonabant (1) were explored in which the 1-aminopiperidine group was switched to a 4-aminopiperidine, attached at the 4-amino position (5). The piperidine nitrogen was functionalized with carbamates, amides, and sulfonamides, providing compounds that are potent inverse agonists of hCB1 with good selectivity for hCB1 over hCB2. Select compounds were further studied using in vitro models of brain penetration, oral absorption and metabolic stability. Several compounds were identified with predicted minimal brain penetration and good metabolic stability. In vivo pharmacokinetic testing revealed that inverse agonist 8c is orally bioavailable and has vastly reduced brain penetration compared to rimonabant. (C) 2016 Elsevier Ltd. All rights reserved.
C1 [Fulp, Alan; Zhang, Yanan; Bortoff, Katherine; Seltzman, Herbert; Snyder, Rodney; Wiethe, Robert; Amato, George; Maitra, Rangan] RTI Int, Discovery Sci & Technol, 3040 Cornwallis Rd, Res Triangle Pk, NC 27709 USA.
C3 Research Triangle Institute
RP Maitra, R (corresponding author), RTI Int, Discovery Sci & Technol, 3040 Cornwallis Rd, Res Triangle Pk, NC 27709 USA.
EM rmaitra@rti.org
RI Seltzman, Herbert/LSJ-1572-2024
OI Snyder, Rodney/0000-0001-5546-3158; Zhang, Yanan/0000-0001-7153-4358;
   Amato, George/0000-0002-3512-1895
FU NIH [AA022235, DK100414]
FX The authors would like to thank Ann Gilliam for performing the binding
   assays, Ms. Sherry Black and Ms. Purvi Patel for help with metabolic
   stability studies. We express our gratitude to the NIDA drug supply
   program for providing radiolabeled probes and to Dr. Brian Thomas for
   supplying the CB1 cells. This research was funded by research Grants
   AA022235 and DK100414 to R.M. from NIH.
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   Reggio P. H., 2010, CURR MED CHEM
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NR 25
TC 19
Z9 20
U1 0
U2 13
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0968-0896
EI 1464-3391
J9 BIOORGAN MED CHEM
JI Bioorg. Med. Chem.
PD MAR 1
PY 2016
VL 24
IS 5
BP 1063
EP 1070
DI 10.1016/j.bmc.2016.01.033
PG 8
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Chemistry,
   Organic
WE Science Citation Index Expanded (SCI-EXPANDED); Index Chemicus (IC)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Chemistry
GA DD5UH
UT WOS:000369989500016
PM 26827137
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Kim, GE
   Kim, MH
   Lim, WJ
   Kim, SI
AF Kim, Ga Eun
   Kim, Min-ho
   Lim, Weon-Jeon
   Kim, Soo In
TI The effects of smoking habit change on the risk of depression-Analysis
   of data from the Korean National Health Insurance Service
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Smoking habit change; Smoking cessation; Smoking reduction; Depression;
   Long-term quitter; National Health Insurance Service-Health; Screening
   Cohort database
ID MAJOR DEPRESSION; CIGARETTE-SMOKING; SELF-ESTEEM; FOLLOW-UP; NICOTINE
   DEPENDENCE; METABOLIC SYNDROME; PHYSICAL-ACTIVITY; ENZYME-ACTIVITIES;
   OXIDATIVE STRESS; CESSATION
AB Background: We examined the effects of smoking habit change on the risk of depression using the National Health Insurance Service-National Health Screening Cohort database of Korea.
   Methods: This nationwide population-based cohort study included 88,931 men aged 40 years or older. The participants were divided into baseline heavy (>= 20 cigarettes/day), moderate (10-19 cigarettes/day), and light (<10 cigarettes/day) smokers, quitters, and never smokers. Smokers were then categorized as continual smokers, reducers, quitters, and non-smokers based on the two-year change in smoking status between the first and second health examinations. The participants were followed from the index date to 2013 to assess depression status. Cox proportional models were used to examine the effects of smoking habit change on the risk of depression.
   Results: After a median 7.7 years of follow-up, 2,833 depression cases were identified. Never smokers and longterm quitters had a lower risk of depression than heavy continual smokers (hazard ratio, HR 0.817; 95% CI, confidence interval 0.689-0.967 and HR: 0.691; 95% CI: 0.559-0.853, respectively). Short-term quitters and reducers had a lower risk of depression, but it was not significant. The influence of smoking on depression was prominent among men in their 50 s (HR: 0.585; 95% CI: 0.419-0.820 in long-term quitters, HR:.0.738; 95% CI: 0.570-0.954 in never smokers).
   Limitations: The information about smoking habits was based on self-reported questionnaires. This study examined only men because the smoking rate among women in Korea is very low.
   Conclusions: This population-based study found that never smokers and long-term quitters have lower risk of depression. The risk of depression decreased when the amount of smoking decreased, but the difference was not statistically significant. Furthermore, more attention should be paid to middle-aged men when formulating smoking cessation policies.
C1 [Kim, Ga Eun; Kim, Soo In] Ewha Womans Univ, Coll Med, Dept Psychiat, Mokdong Hosp, Seoul, South Korea.
   [Kim, Min-ho] Ewha Womans Univ, Informatizat Dept, Seoul Hosp, Seoul, South Korea.
   [Lim, Weon-Jeon] Ewha Womans Univ, Coll Med, Dept Psychiat, Seoul Hosp, Seoul, South Korea.
C3 Ewha Womans University; Ewha Womans University; Ewha Womans University
RP Kim, SI (corresponding author), Ewha Womans Univ, Coll Med, Dept Psychiat, Mokdong Hosp, Seoul, South Korea.
EM 72sooik@ewha.ac.kr
RI Kim, Yong Sung/GMW-8652-2022
OI Kim, Min-ho/0000-0003-4909-2308
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NR 63
TC 3
Z9 3
U1 0
U2 8
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD APR 1
PY 2022
VL 302
BP 293
EP 301
DI 10.1016/j.jad.2022.01.095
EA FEB 2022
PG 9
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA ZN2UE
UT WOS:000764895000027
PM 35085672
DA 2025-06-11
ER

PT J
AU Lambert, E
   Dawood, T
   Schlaich, M
   Straznicky, N
   Esler, M
   Lambert, G
AF Lambert, Elisabeth
   Dawood, Tye
   Schlaich, Markus
   Straznicky, Nora
   Esler, Murray
   Lambert, Gavin
TI Single-unit sympathetic discharge pattern in pathological conditions
   associated with elevated cardiovascular risk
SO CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
LA English
DT Article; Proceedings Paper
CT 4th Franco-Australian Meeting on Hypertension
CY SEP 09-12, 2007
CL Kakadu Natl Pk, AUSTRALIA
SP INSERM, Natl Hlth & Med Res Council Australis
DE cardiovascular risk; microneurography; sympathetic nervous system
ID MUSCLE VASOCONSTRICTOR NEURONS; OBESITY-RELATED HYPERTENSION;
   CONGESTIVE-HEART-FAILURE; METABOLIC SYNDROME; FIRING PROPERTIES; NERVOUS
   ACTIVITY; PANIC DISORDER; SYMPATHOEXCITATION; DISEASE; STIMULATION
AB 1. Although measuring the rate of firing of multi-unit muscle sympathetic nerve activity (MSNA) has provided important information in many aspects of cardiovascular medicine, measuring single-unit vasoconstrictor activity provides a better understanding of the possible mechanisms underlying disturbed sympathetic nervous system activity.
   2. Detailed firing patterns of sympathetic vasoconstrictor neurons have been recorded in conditions associated with sympathoexcitation such as heart failure, obstructive sleep apnoea syndrome, hypertension and obesity; conditions in which cardiovascular morbidity and mortality are demonstrably elevated.
   3. Moreover, in conditions such as anxiety disorders and depression, in which elevated cardiovascular risk has recently been established, single-unit analysis has highlighted a disturbed sympathetic firing pattern, which could not be identified on multi-unit MSNA recording. This disturbed sympathetic nerve firing pattern, characterized by increased incidence of multiple firing within a sympathetic burst, has deleterious consequences on the cardiovascular system.
   4. Single-unit methodology may represent a major step forward in the understanding of the link between disturbed sympathetic nerve firing and associated cardiovascular risk.
C1 [Lambert, Elisabeth; Dawood, Tye; Schlaich, Markus; Straznicky, Nora; Esler, Murray; Lambert, Gavin] Baker Heart Res Inst, Human Neurotransmitters Lab, Melbourne, Vic 8008, Australia.
C3 Baker Heart and Diabetes Institute
RP Lambert, E (corresponding author), Baker Heart Res Inst, Human Neurotransmitters Lab, POB 6492,St Kilda Rd Central, Melbourne, Vic 8008, Australia.
EM elisabeth.lambert@baker.edu.au
RI Straznicky, Nora/E-7484-2010; Schlaich, Markus/E-7468-2010; Lambert,
   Gavin/E-7384-2010; Lambert, Elisabeth/E-7463-2010; Dawood,
   Tye/A-8826-2011
OI Lambert, Elisabeth/0000-0002-2232-9048; Lambert,
   Gavin/0000-0003-0315-645X; Schlaich, Markus/0000-0002-1765-0195
CR ANDERSSON PO, 1983, J PHYSIOL-LONDON, V334, P293, DOI 10.1113/jphysiol.1983.sp014495
   BARTON D, 2007, J HYPERTENS
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NR 28
TC 35
Z9 42
U1 0
U2 3
PU BLACKWELL PUBLISHING
PI OXFORD
PA 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND
SN 0305-1870
J9 CLIN EXP PHARMACOL P
JI Clin. Exp. Pharmacol. Physiol.
PD APR
PY 2008
VL 35
IS 4
BP 503
EP 507
DI 10.1111/j.1440-1681.2008.04905.x
PG 5
WC Pharmacology & Pharmacy; Physiology
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Physiology
GA 278OQ
UT WOS:000254296600031
PM 18307750
DA 2025-06-11
ER

PT J
AU Song, TR
   Zhao, Y
   Zhu, XY
   Eirin, A
   Krier, JD
   Tang, H
   Jordan, KL
   Lerman, A
   Lerman, L
AF Song, Turun
   Zhao, Yu
   Zhu, Xiangyang
   Eirin, Alfonso
   Krier, James
   Tang, Hui
   Jordan, Kyra L.
   Lerman, Amir
   Lerman, Lilach
TI Superimposition of metabolic syndrome magnifies post-stenotic kidney
   injury in dyslipidemic pigs
SO AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
LA English
DT Article
DE Renal artery stenosis; atherosclerosis; metabolic syndrome;
   dyslipidemia; insulin resistance
ID INSULIN-RESISTANCE; OXIDATIVE STRESS; EARLY ATHEROSCLEROSIS; ADIPOSITY;
   OBESITY; FRUCTOSE; DISEASE; HYPERTENSION; INFLAMMATION; DYSFUNCTION
AB Background: Dyslipidemia aggravates kidney injury distal to atherosclerotic renal artery stenosis (ARAS). Besides dyslipidemia, metabolic syndrome (MetS) also involves development of obesity and insulin-resistance (IR). We hypothesized that concurrent obesity and IR magnify swine stenotic-kidney damage beyond dyslipidemia. Methods: Pigs with unilateral RAS were studied after 16 weeks of atherogenic diets without (ARAS) or with (MetS + RAS) development of obesity/IR (n=6 each). Additional pigs on normal diet served as normal or non-dyslipidemic RAS controls (n=6 each). Stenotic-kidney renal blood flow (RBF), glomerular filtration rate (GFR), and microvascular architecture were studied using CT, and oxygenation was studied using blood oxygen level-dependent magnetic-resonance-imaging. We further compared kidney adiposity, oxidative stress, inflammation, apoptosis, fibrosis, and systemic levels of oxidative and inflammatory cytokines. Results: ARAS and MetS + RAS developed hypertension and dyslipidemia, and MetS + RAS also developed obesity and IR. RBF and GFR were similarly decreased in all post-stenotic pig kidneys compared to normal pig kidneys, yet MetS + RAS aggravated and expanded medullary hypoxia and microvascular loss. RAS and ARAS increased systemic levels of tumor necrosis factor (TNF)-alpha, which were further elevated in MetS + RAS. Renal oxidative stress and TNF-alpha expression increased in ARAS and further in MetS + RAS, which also upregulated expression of anti angiogenic angiostatin, and magnified apoptosis, tubular injury, and fibrosis. Conclusion: Beyond dyslipidemia, obesity and insulin-resistance aggravate damage in the post-stenotic kidney in MetS, despite relative hyperfiltration-related preservation of renal function. These observations underscore the need to control systemic metabolic disturbances in order to curb renal damage in subjects with ischemic kidney disease.
C1 [Song, Turun; Zhao, Yu; Zhu, Xiangyang; Eirin, Alfonso; Krier, James; Tang, Hui; Jordan, Kyra L.; Lerman, Lilach] Mayo Clin, Div Nephrol & Hypertens, Rochester, MN 55905 USA.
   [Song, Turun] Sichuan Univ, West China Hosp, Urol Res Inst, Organ Transplantat Ctr,Urol Dept, Chengdu, Sichuan, Peoples R China.
   [Lerman, Amir] Mayo Clin, Dept Cardiovasc Dis, Rochester, MN 55905 USA.
C3 Mayo Clinic; Sichuan University; Mayo Clinic
RP Lerman, L (corresponding author), Mayo Clin, Div Nephrol & Hypertens, Rochester, MN 55905 USA.
EM Lerman.Lilach@Mayo.Edu
RI Lerman, Lilach/M-4962-2017; Song, Turun/NAZ-1900-2025; Eirin,
   Alfonso/N-9873-2013
OI Eirin, Alfonso/0000-0002-3864-9644
FU National Institutes of Health [DK122734, DK-120292, AG062104]; China
   Scholarship Council
FX This research was partly supported by National Institutes of Health
   grants DK122734, DK-120292, and AG062104. We thank the China Scholarship
   Council for their support.
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NR 50
TC 3
Z9 3
U1 0
U2 2
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 1943-8141
J9 AM J TRANSL RES
JI Am. J. Transl. Res.
PY 2021
VL 13
IS 8
BP 8965
EP 8976
PG 12
WC Oncology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Research & Experimental Medicine
GA UM6AJ
UT WOS:000693411900014
PM 34540008
DA 2025-06-11
ER

PT J
AU Prabhakar, P
   Reeta, KH
   Maulik, SK
   Dinda, AK
   Gupta, YK
AF Prabhakar, Pankaj
   Reeta, K. H.
   Maulik, S. K.
   Dinda, A. K.
   Gupta, Y. K.
TI Protective effect of thymoquinone against high-fructose diet-induced
   metabolic syndrome in rats
SO EUROPEAN JOURNAL OF NUTRITION
LA English
DT Article
DE Thymoquinone; High-fructose diet; Metabolic syndrome; Insulin
   resistance; Oxidative stress; Peroxisome proliferator-activated
   receptors (PPARs)
ID OXIDATIVE STRESS; NIGELLA-SATIVA; PPAR-GAMMA; INSULIN-RESISTANCE;
   HYPERTENSION; PREVENTS; PIOGLITAZONE; OBESITY; HYPERTROPHY; ACTIVATION
AB Thymoquinone (TQ), a bioactive constituent of Nigella sativa (Linn.) seed, which is commonly used as a spice in Asian food, has been reported to possess a wide range of biological effects. The present study evaluated the effect of TQ on high-fructose diet (HFD)-induced metabolic syndrome (MetS) in male Wistar rats.
   MetS was induced by 60 % HFD over 42 days. TQ (25, 50 and 100 mg/kg, p.o. once daily) was administered along with HFD for 42 days. Pioglitazone (10 mg/kg, p.o. once daily) was used as a standard drug. Plasma glucose, triglycerides, total cholesterol and HDL-cholesterol were estimated on days 0 and 42. Change in blood pressure, oral glucose tolerance and insulin resistance were measured. Hepatic thiobarbituric acid reactive substances (TBARS), reduced glutathione (GSH), superoxide dismutase (SOD) and catalase levels were estimated as measures of hepatic oxidative stress. Hepatic mRNA of PPAR-alpha and PPAR-gamma was also studied.
   TQ prevented the characteristic features of HFD-induced MetS, such as hyperglycaemia, hypertriglyceridemia, hypercholesterolaemia and elevated systolic blood pressure. TQ also prevented impaired glucose tolerance and insulin resistance. It also ameliorated HFD-induced increase in hepatic TBARS and depletion of SOD, catalase and GSH. TQ prevented reduction in hepatic mRNA of PPAR-alpha and PPAR-gamma in HFD rats, and the effects were comparable to those of pioglitazone.
   This study demonstrates protective effect of TQ against HFD-induced MetS on rats which might have been mediated via PPAR mechanism.
C1 [Prabhakar, Pankaj; Reeta, K. H.; Maulik, S. K.; Gupta, Y. K.] All India Inst Med Sci, Dept Pharmacol, New Delhi 110029, India.
   [Dinda, A. K.] All India Inst Med Sci, Dept Pathol, New Delhi 110029, India.
C3 All India Institute of Medical Sciences (AIIMS) New Delhi; All India
   Institute of Medical Sciences (AIIMS) New Delhi
RP Reeta, KH (corresponding author), All India Inst Med Sci, Dept Pharmacol, New Delhi 110029, India.
EM reetakh@gmail.com
RI Prabhakar, Dr. Pankaj/GOH-1003-2022; Reeta, Kh/AAU-2462-2021
OI Prabhakar, Dr. Pankaj/0000-0002-1630-4258
FU Indian Council of Medical Research (ICMR), New Delhi, India
FX Authors gratefully acknowledge the Indian Council of Medical Research
   (ICMR), New Delhi, India, for financial support.
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NR 55
TC 33
Z9 35
U1 0
U2 10
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1436-6207
EI 1436-6215
J9 EUR J NUTR
JI Eur. J. Nutr.
PD OCT
PY 2015
VL 54
IS 7
BP 1117
EP 1127
DI 10.1007/s00394-014-0788-7
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA CR8WK
UT WOS:000361634700008
PM 25347965
DA 2025-06-11
ER

PT J
AU Santilli, F
   Blardi, P
   Scapellato, C
   Bocchia, M
   Guazzi, G
   Terzuoli, L
   Tabucchi, A
   Silvietti, A
   Lucani, B
   Gioffrè, WR
   Scarpini, F
   Fazio, F
   Davì, G
   Puccetti, L
AF Santilli, Francesca
   Blardi, Patrizia
   Scapellato, Carlo
   Bocchia, Monica
   Guazzi, Gianni
   Terzuoli, Lucia
   Tabucchi, Antonella
   Silvietti, Antonella
   Lucani, Benedetta
   Gioffre, Walter Renato
   Scarpini, Francesca
   Fazio, Francesca
   Davi, Giovanni
   Puccetti, Luca
TI Decreased plasma endogenous soluble RAGE, and enhanced adipokine
   secretion, oxidative stress and platelet/coagulative activation identify
   non-alcoholic fatty liver disease among patients with familial combined
   hyperlipidemia and/or metabolic syndrome
SO VASCULAR PHARMACOLOGY
LA English
DT Article
DE esRAGE; FCHL; Metabolic syndrome; NAFLD; Atherothrombosis; CD40/CD40L
ID CARDIOVASCULAR-DISEASE; GENETIC INFLUENCE; RISK; RECEPTOR; ATORVASTATIN;
   STEATOSIS; DIAGNOSIS; MARKERS; LEVEL; HEART
AB Objective: In patients with familial combined hyperlipidemia (FCHL), without metabolic syndrome (MS), occurrence of non-alcoholic fatty liver disease (NAFLD) is related to a specific pro-inflammatory profile, influenced by genetic traits, involved in oxidative stress and adipokine secretion. Among FCHL or MS patients, hyperactivity of the ligand-receptor for advanced glycation-end-products (RAGE) pathway, as reflected by inadequate protective response by the endogenous secretory (es)RAGE, in concert with genetic predisposition, may identify those with NAFLD even before and regardless of MS.
   Methods: We cross-sectionally compared 60 patients with vs. 50 without NAFLD. Each group included patients with FCHL alone, MS alone, and FCHL plus MS.
   Results: NAFLD patients had significantly lower plasma esRAGE, IL-10 and adiponectin, and higher CD40 ligand, endogenous thrombin potential and oxidized LDL. The effects of MS plus FCHL were additive. The genotypic cluster including LOX-I IVS4-14A plus ADIPO 45GG and 256 GT/GG plus IL-10 10-1082G, together with higher esRAGE levels highly discriminate FCHL and MS patients not developing NAFLD.
   Conclusions: Among FCHL or MS patients, noncarriers of the protective genotypic cluster, with lower esRAGE and higher degree of atherothrombotic abnormalities coincide with the diagnosis of NAFLD. This suggests an interplay between genotype, adipokine secretion, oxidative stress and platelet/coagulative activation, accelerating NAFLD occurrence as a proxy for cardiovascular disease. (C) 2015 Elsevier Inc. All rights reserved.
C1 [Santilli, Francesca; Fazio, Francesca; Davi, Giovanni] Univ G dAnnunzio, Dept Med & Aging, Chieti, Italy.
   [Blardi, Patrizia] Univ Siena, Clin Pharmacol, I-53100 Siena, Italy.
   [Scapellato, Carlo; Terzuoli, Lucia; Tabucchi, Antonella; Silvietti, Antonella] Univ Teaching Hosp Siena, Div Clin Pathol, Siena, Italy.
   [Bocchia, Monica; Lucani, Benedetta; Puccetti, Luca] Univ Siena, Div Hematol, I-53100 Siena, Italy.
   [Guazzi, Gianni] Univ Teaching Hosp Siena, Unit Emergency Radiol, Siena, Italy.
   [Gioffre, Walter Renato] Univ Siena, Prevent Med CIRAS, I-53100 Siena, Italy.
   [Scarpini, Francesca; Puccetti, Luca] Univ Siena, Atherothrombosis Ctr, I-53100 Siena, Italy.
C3 G d'Annunzio University of Chieti-Pescara; University of Siena;
   University of Siena; University Hospital of Siena; University of Siena;
   University of Siena; University Hospital of Siena; University of Siena;
   University of Siena
RP Puccetti, L (corresponding author), Policlin Santa Maria Scotte, Div Hematol, Vle Bracci 18, I-53100 Siena, Italy.
EM luca.puccetti@unisi.it
RI Santilli, Francesca/ABC-6243-2021; Davì, Giovanni/K-7659-2016; Pisani,
   Francesco/ISR-8949-2023; Bocchia, Monica Bocchia/AIB-9508-2022
OI PUCCETTI, LUCA/0000-0002-4022-8822; Santilli,
   Francesca/0000-0002-4593-905X
FU University of Siena
FX The study was partially supported by a Grant from University of Siena
   (PAR2007) to LP. The Institution had no involvement in study design, in
   the collection, analysis and interpretation of data, in the writing of
   the report, and in the decision to submit the article for publication.
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NR 48
TC 26
Z9 28
U1 0
U2 2
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1537-1891
EI 1879-3649
J9 VASC PHARMACOL
JI Vasc. Pharmacol.
PD SEP
PY 2015
VL 72
BP 16
EP 24
DI 10.1016/j.vph.2015.04.004
PG 9
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA CQ0XU
UT WOS:000360322700003
PM 26117210
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Korkmaz, GG
   Altinoglu, E
   Civelek, S
   Sozer, V
   Erdenen, F
   Tabak, O
   Uzun, H
AF Korkmaz, Gulcan G.
   Altinoglu, Esma
   Civelek, Sabiha
   Sozer, Volkan
   Erdenen, Fusun
   Tabak, Omur
   Uzun, Hafize
TI The association of oxidative stress markers with conventional risk
   factors in the metabolic syndrome
SO METABOLISM-CLINICAL AND EXPERIMENTAL
LA English
DT Article
DE Metabolic syndrome; Advanced protein oxidation products; Total
   antioxidant capacity; Pro-oxidant-antioxidant balance
ID PROOXIDANT-ANTIOXIDANT BALANCE; URIC-ACID; OBESITY; PARAOXONASE;
   PARAMETERS; CAPACITY; COMPONENTS; ADULTS
AB Background and Aims. The metabolic syndrome (MetS) is a common and complex disorder that consists of various abnormalities, including dyslipidemia, obesity, hypertension and hyperglycemia. We investigated the relationships between the levels of advanced protein oxidation products (AOPPs), the total antioxidant capacity (TAC) and the pro-oxidant-antioxidant balance (PAB) in MetS patients.
   Methods. A total of 55 patients (37 women, 18 men) with MetS and 20 healthy controls (14 women, 6 men) with a body mass index (BMI) less than 25 kg/m(2) were enrolled in the study. Colorimetric methods were used to determine the levels of AOPPs, the TAC, and the PAB.
   Results. AOPP, TAC, and PAB values were significantly higher in patients with MetS than in control subjects (p<0.001, p = 0.050, and p<0.001, respectively). A positive correlation was observed between the AOPP levels and the glucose, triglyceride, insulin and HOMA-IR levels. PAB values also exhibited significant positive correlations with diastolic blood pressure and fibrinogen levels. Logistic regression analysis revealed that higher serum PAB values were positively and independently associated with the MetS (odds ratio: 1.110; 95% confidence interval: 1.006-1.224; P<0.37).
   Conclusions. Increased AOPP levels and higher PAB values are likely to be a result of oxidative stress, a condition in which an imbalance occurs between the production and inactivation of reactive oxygen species. In addition, it appears that serum PAB values may accurately reflect the levels of oxidative stress in MetS patients. Crown Copyright (C) 2013 Published by Elsevier Inc. All rights reserved.
C1 [Korkmaz, Gulcan G.] Kirklareli Univ, Sch Hlth, Kirklareli, Turkey.
   [Altinoglu, Esma; Erdenen, Fusun] Istanbul Educ & Res Hosp, Internal Med Clin, Istanbul, Turkey.
   [Civelek, Sabiha; Uzun, Hafize] Istanbul Univ, Cerrahpasa Med Fac, Dept Biochem, Istanbul, Turkey.
   [Sozer, Volkan] Yildiz Tech Univ, Dept Biochem, Istanbul, Turkey.
   [Tabak, Omur] Istanbul Kanuni Sultan Suleyman Educ & Res Hosp, Internal Med Clin, Istanbul, Turkey.
C3 Kirklareli University; Istanbul Training & Research Hospital; Istanbul
   University - Cerrahpasa; Istanbul University; Yildiz Technical
   University; Istanbul Kanuni Sultan Suleyman Training & Research Hospital
RP Uzun, H (corresponding author), Cerrahpasa Tip Fak, Temel Bilimler Tibbi Biyokimya Anabilim Dali, TR-34303 Cerrahpasa, Turkey.
EM huzun59@hotmail.com
RI Uzun, Hafize/D-4811-2019; Guntas, Gulcan/B-9262-2014
OI Uzun, Hafize/0000-0002-1347-8498; Guntas, Gulcan/0000-0002-3638-4662
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NR 43
TC 68
Z9 73
U1 0
U2 23
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0026-0495
EI 1532-8600
J9 METABOLISM
JI Metab.-Clin. Exp.
PD JUN
PY 2013
VL 62
IS 6
BP 828
EP 835
DI 10.1016/j.metabol.2013.01.002
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 155YD
UT WOS:000319785400010
PM 23410746
DA 2025-06-11
ER

PT J
AU Miralles-Pérez, B
   Méndez, L
   Nogués, MR
   Sánchez-Martos, V
   Fortuño-Mar, A
   Ramos-Romero, S
   Hereu, M
   Medina, I
   Romeu, M
AF Miralles-Perez, Bernat
   Mendez, Lucia
   Nogues, Maria Rosa
   Sanchez-Martos, Vanessa
   Fortuno-Mar, Angels
   Ramos-Romero, Sara
   Hereu, Merce
   Medina, Isabel
   Romeu, Marta
TI Effects of a Fish Oil Rich in Docosahexaenoic Acid on Cardiometabolic
   Risk Factors and Oxidative Stress in Healthy Rats
SO MARINE DRUGS
LA English
DT Article
DE eicosapentaenoic acid; soybean oil; coconut oil; cholesterol; glucose;
   inflammation; lipid peroxidation; protein carbonylation
ID POLYUNSATURATED FATTY-ACIDS; CARDIOVASCULAR-DISEASE; EICOSAPENTAENOIC
   ACID; OMEGA-3 PUFAS; INFLAMMATION; PLASMA; DIET; SUPPLEMENTATION;
   POLYPHENOLS; GLUTATHIONE
AB Omega-3 polyunsaturated fatty acids are associated with a lower risk of cardiometabolic diseases. However, docosahexaenoic acid (DHA) is easily oxidized, leading to cellular damage. The present study examined the effects of an increased concentration of DHA in fish oil (80% of total fatty acids) on cardiometabolic risk factors and oxidative stress compared to coconut oil, soybean oil, and fish oil containing eicosapentaenoic acid (EPA) and DHA in a balanced ratio. Forty healthy male Sprague-Dawley rats were supplemented with corresponding oil for 10 weeks. Supplementation with the fish oil containing 80% DHA decreased plasma fat, plasma total cholesterol and muscle fat compared to the coconut oil and the soybean oil. Increasing concentrations of DHA induced incorporation of DHA and EPA in cell membranes and tissues along with a decrease in omega-6 arachidonic acid. The increase in DHA promoted lipid peroxidation, protein carbonylation and antioxidant response. Taken together, the increased concentration of DHA in fish oil reduced fat accumulation compared to the coconut oil and the soybean oil. This benefit was accompanied by high lipid peroxidation and subsequent protein carbonylation in plasma and in liver. In our healthy framework, the slightly higher carbonylation found after receiving fish oil containing 80% DHA might be a protecting mechanism, which fit with the general improvement of antioxidant defense observed in those rats.</p>
C1 [Miralles-Perez, Bernat; Nogues, Maria Rosa; Sanchez-Martos, Vanessa; Romeu, Marta] Univ Rovira & Virgili, Dept Basic Med Sci, Pharmacol Unit, Funct Nutr Oxidat & Cardiovasc Dis Res Grp NFOC S, C St Llorenc 21, E-43201 Reus, Spain.
   [Mendez, Lucia; Medina, Isabel] Inst Marine Res IIM CSIC, Dept Food Technol, Chem Marine Prod, C Eduardo Cabello 6, E-36208 Vigo, Spain.
   [Fortuno-Mar, Angels] Eldine Patol, C Plom 32, E-43006 Tarragona, Spain.
   [Ramos-Romero, Sara; Hereu, Merce] Inst Adv Chem Catalonia IQAC CSIC, Dept Biol Chem, C Jordi Girona 18-26, E-08034 Barcelona, Spain.
   [Ramos-Romero, Sara] Univ Barcelona, Fac Biol, Dept Cell Biol Physiol & Immunol, Avd Diagonal 643, E-08028 Barcelona, Spain.
C3 Universitat Rovira i Virgili; Consejo Superior de Investigaciones
   Cientificas (CSIC); CSIC - Instituto de Investigaciones Marinas (IIM);
   Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Centro de
   Investigacion y Desarrollo Pascual Vila (CID-CSIC); CSIC - Instituto de
   Quimica Avanzada de Cataluna (IQAC); University of Barcelona
RP Nogués, MR (corresponding author), Univ Rovira & Virgili, Dept Basic Med Sci, Pharmacol Unit, Funct Nutr Oxidat & Cardiovasc Dis Res Grp NFOC S, C St Llorenc 21, E-43201 Reus, Spain.
EM bernat.miralles@urv.cat; luciamendez@iim.csic.es;
   mariarosa.nogues@urv.cat; vanessa.sanchez@urv.cat;
   afortunyo@eldinepatologia.org; sara.ramosromero@ub.edu;
   merce.hereu@iqac.csic.es; medina@iim.csic.es; marta.romeu@urv.cat
RI Ramos-Romero, Sara/AAH-6209-2020; Miralles-Pérez, Bernat/ABI-2034-2020;
   Nogués, M./ABH-5645-2020; ROMEU, MARTA/O-7129-2019; ROMEU,
   MARTA/A-8468-2014; Mendez, Lucia/T-7016-2017; Ramos-Romero,
   Sara/K-8301-2017
OI ROMEU, MARTA/0000-0002-2131-1858; Mendez, Lucia/0000-0002-9711-2994;
   Ramos-Romero, Sara/0000-0002-9293-4454; Miralles-Perez,
   Bernat/0000-0003-1294-7069
FU Spanish Ministry of Economy and Competitiveness [AGL2013-49079-C2-1-R,
   AGL2013-49079-C2-2-R, AGL2017-83599-R, RTI2018-095659-B-I00]
FX This research was funded by the Spanish Ministry of Economy and
   Competitiveness (grant numbers AGL2013-49079-C2-1-R,
   AGL2013-49079-C2-2-R, AGL2017-83599-R and RTI2018-095659-B-I00).
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NR 81
TC 10
Z9 11
U1 1
U2 17
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1660-3397
J9 MAR DRUGS
JI Mar. Drugs
PD OCT
PY 2021
VL 19
IS 10
AR 555
DI 10.3390/md19100555
PG 19
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA WN6CK
UT WOS:000711854200001
PM 34677454
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Sugizaki, T
   Watanabe, M
   Horai, Y
   Kaneko-Iwasaki, N
   Arita, E
   Miyazaki, T
   Morimoto, K
   Honda, A
   Irie, J
   Itoh, H
AF Sugizaki, Taichi
   Watanabe, Mitsuhiro
   Horai, Yasushi
   Kaneko-Iwasaki, Nao
   Arita, Eri
   Miyazaki, Teruo
   Morimoto, Kohkichi
   Honda, Akira
   Irie, Junichiro
   Itoh, Hiroshi
TI The Niemann-Pick C1 Like 1 (NPC1L1) Inhibitor Ezetimibe Improves
   Metabolic Disease Via Decreased Liver X Receptor (LXR) Activity in Liver
   of Obese Male Mice
SO ENDOCRINOLOGY
LA English
DT Article
ID STEAROYL-COA DESATURASE-1; UNSATURATED FATTY-ACIDS; GLUCOSE-METABOLISM;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; LIPID-METABOLISM; CHOLESTEROL
   ABSORPTION; DIETARY-CHOLESTEROL; ROS PRODUCTION; VISCERAL FAT
AB Dyslipidemic patients with diabetes mellitus, including metabolic syndrome, are at increased risk of coronary heart disease. It has been reported that ezetimibe, a cholesterol absorption inhibitor, improves metabolic diseases in mice and humans. However, the underlying mechanism has been unclear. Here we explored the effects of ezetimibe on lipid and glucose homeostasis. Male KK-A(y) mice were fed a high-fat diet, which is the mouse model of metabolic syndrome, with or without ezetimibe for 14 weeks. Ezetimibe improved dyslipidemia, steatosis, and insulin resistance. Ezetimibe decreased hepatic oxysterols, which are endogenous agonists of liver X receptor (LXR), to decrease hepatic lipogenic gene expressions, especially in stearoyl-CoA desaturase-1 (SCD1), leading to a remarkable reduction of hepatic oleate content that would contribute to the improvement of steatosis by reducing triglycerides and cholesterol esters. Simultaneously, hepatic beta-oxidation, NADPH oxidase and cytochrome P450 2E1 (CYP2E1) were reduced, and thus reactive oxygen species (ROS) and inflammatory cytokines were also decreased. Consistent with these changes, ezetimibe diminished c-Jun N-terminal kinase (JNK) phosphorylation and improved insulin signaling in the liver. In vitro study using primary hepatocytes obtained from male SD rats, treated with oleate and LXR agonist, showed excess lipid accumulation, increased oxidative stress and impaired insulin signaling. Therefore, in obese subjects, ezetimibe reduces hepatic LXR activity by reducing hepatic oxysterols to lower hepatic oleate content. This improves steatosis and reduces oxidative stress, and this reduction improves insulin signaling in the liver. These results provide insight into pathogenesis and strategies for treatment of the metabolic syndrome.
C1 [Sugizaki, Taichi; Watanabe, Mitsuhiro; Horai, Yasushi; Kaneko-Iwasaki, Nao; Arita, Eri; Morimoto, Kohkichi; Irie, Junichiro; Itoh, Hiroshi] Keio Univ, Sch Med, Dept Internal Med, Hlth Sci Lab, Tokyo 1608582, Japan.
   [Watanabe, Mitsuhiro] Keio Univ, Grad Sch Media & Governance, Tokyo 1608582, Japan.
   [Miyazaki, Teruo; Honda, Akira] Tokyo Med Univ, Ctr Collaborat Res, Ibaraki Med Ctr, Ibaraki 3000332, Japan.
C3 Keio University; Keio University; Tokyo Medical University
RP Watanabe, M (corresponding author), Keio Univ, Sch Med, Dept Internal Med,Hlth Sci Lab, Grad Sch Media & Governance,Fac Environm & Inform, 5322 Endo, Fujisawa, Kanagawa 2520882, Japan.
EM wmitsu@sfc.keio.ac.jp
RI Irie, Junichiro/H-7795-2019; Honda, Akira/ACN-8249-2022; Miyazaki,
   Teruo/ABA-8379-2021
OI Irie, Junichiro/0000-0003-2662-4121; Honda, Akira/0000-0003-0902-8272;
   Miyazaki, Teruo/0000-0001-9796-3011
FU Japan Health Foundation; Ministry of Education, Culture, Sports, Science
   and Technology of Japan; Grants-in-Aid for Scientific Research
   [24591342] Funding Source: KAKEN
FX This work was supported by grants from the Japan Health Foundation and
   the Ministry of Education, Culture, Sports, Science and Technology of
   Japan.
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NR 43
TC 26
Z9 27
U1 1
U2 10
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0013-7227
EI 1945-7170
J9 ENDOCRINOLOGY
JI Endocrinology
PD AUG
PY 2014
VL 155
IS 8
BP 2810
EP 2819
DI 10.1210/en.2013-2143
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA AP8QL
UT WOS:000342343800008
PM 24773344
OA Bronze
DA 2025-06-11
ER

PT J
AU Wu, W
   Wu, M
   Wang, YL
   Jiang, XS
   Li, G
AF Wu, Wei
   Wu, Meng
   Wang, Yongli
   Jiang, Xuesheng
   Li, Gang
TI Ultrasonic examination of differences in bone density of chronic
   obstructive pulmonary disease (COPD) rats constructed by different
   methods
SO ANNALS OF PALLIATIVE MEDICINE
LA English
DT Article
DE Ultrasound; chronic obstructive pulmonary disease (COPD); rat; bone
   mineral density
ID METABOLIC SYNDROME; DEPRESSION; ANXIETY
AB Background: Osteoporosis is one of the main complications of chronic obstructive pulmonary disease (COPD) patients. We investigated the bone density in rat model of COPD induced by different method.
   Methods: We developed seven distinct groups to evaluate the differences in bone density. Based on these seven different ways, rats were categorized into distinct groups in which simple cigarette inhalation, sulfur dioxide inhalation, lipopolysaccharide intubation, protease induction, bacterial nasal injection, smoking combined with endotoxin, smoking combined bacterial infection, and smoking combined with protease were tested. The results from the male Sprague-Dawley (SD) rats were used to construct the COPD model, and then the bone density of the rats' right femurs was examined by the ultrasonic bone density testing.
   Results: The compound factor- induced COPD rat model provides a better simulation of the clinical characteristics and pathophysiological processes of COPD. Smoking combined with bacterial infection method has the most apparent effect on reducing bone density, with statistical differences (P<0.05).
   Conclusions: The COPD rat model constructed by the combination of smoking and bacterial infection method has a much lower bone density.
C1 [Wu, Wei] Huzhou Univ, Huzhou Cent Hosp, Dept Ultrasonog, Affiliated Cent Hosp, Huzhou, Peoples R China.
   [Wu, Meng; Wang, Yongli; Jiang, Xuesheng] Huzhou Univ, Huzhou Cent Hosp, Dept Orthoped, Affiliated Cent Hosp, Huzhou, Peoples R China.
   [Li, Gang] Zhejiang Chinese Med Univ, Huzhou Tradit Chinese Med Hosp, Med Oncol, Huzhou, Peoples R China.
C3 Huzhou University; Huzhou University; Zhejiang Chinese Medical
   University
RP Li, G (corresponding author), Huzhou Tradit Chinese Med Hosp, 315 Nanjie, Wuxing Dist 313000, Huzhou, Peoples R China.
EM wuweiwuweivivian@163.com
FU Zhejiang Provincial Public Welfare Technology Applied Research
   Laboratory Animal Project [2017C37119]; Huzhou Public Welfare General
   Project [2018GYB42]
FX This work supported by Zhejiang Provincial Public Welfare Technology
   Applied Research Laboratory Animal Project (No. 2017C37119) and Huzhou
   Public Welfare General Project (No.2018GYB42).
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NR 19
TC 1
Z9 5
U1 1
U2 10
PU AME PUBLISHING COMPANY
PI SHATIN
PA FLAT-RM C 16F, KINGS WING PLAZA 1, NO 3 KWAN ST, SHATIN, HONG KONG
   00000, PEOPLES R CHINA
SN 2224-5820
EI 2224-5839
J9 ANN PALLIAT MED
JI Ann. Pallliat. Med.
PD JUL
PY 2020
VL 9
IS 4
BP 1872
EP 1878
DI 10.21037/apm-20-1047
PG 7
WC Health Care Sciences & Services
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Health Care Sciences & Services
GA MT5WK
UT WOS:000555045100057
PM 32576013
OA gold
DA 2025-06-11
ER

PT J
AU Howard, A
   Carroll-Portillo, A
   Alcock, J
   Lin, HC
AF Howard, Andrea
   Carroll-Portillo, Amanda
   Alcock, Joe
   Lin, Henry C.
TI Dietary Effects on the Gut Phageome
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE microbiome; bacteriophage; phageome; diet; dysbiosis
ID CHAIN FATTY-ACIDS; SEVERE ACUTE MALNUTRITION; GRAPE SEED EXTRACT;
   GLUTEN-FREE DIET; ESCHERICHIA-COLI; POMEGRANATE POLYPHENOLS; IMMUNE
   FUNCTION; MICROBIOTA; DNA; BACTERIAL
AB As knowledge of the gut microbiome has expanded our understanding of the symbiotic and dysbiotic relationships between the human host and its microbial constituents, the influence of gastrointestinal (GI) microbes both locally and beyond the intestine has become evident. Shifts in bacterial populations have now been associated with several conditions including Crohn's disease (CD), Ulcerative Colitis (UC), irritable bowel syndrome (IBS), Alzheimer's disease, Parkinson's Disease, liver diseases, obesity, metabolic syndrome, anxiety, depression, and cancers. As the bacteria in our gut thrive on the food we eat, diet plays a critical role in the functional aspects of our gut microbiome, influencing not only health but also the development of disease. While the bacterial microbiome in the context of disease is well studied, the associated gut phageome-bacteriophages living amongst and within our bacterial microbiome-is less well understood. With growing evidence that fluctuations in the phageome also correlate with dysbiosis, how diet influences this population needs to be better understood. This review surveys the current understanding of the effects of diet on the gut phageome.
C1 [Howard, Andrea] Univ New Mexico, Sch Med, Albuquerque, NM 87131 USA.
   [Carroll-Portillo, Amanda; Lin, Henry C.] Univ New Mexico, Div Gastroenterol & Hepatol, Albuquerque, NM 87131 USA.
   [Alcock, Joe] Univ New Mexico, Dept Emergency Med, Albuquerque, NM 87131 USA.
   [Lin, Henry C.] New Mexico VA Hlth Care Syst, Med Serv, Albuquerque, NM 87108 USA.
C3 University of New Mexico; University of New Mexico; University of New
   Mexico
RP Carroll-Portillo, A; Lin, HC (corresponding author), Univ New Mexico, Div Gastroenterol & Hepatol, Albuquerque, NM 87131 USA.; Lin, HC (corresponding author), New Mexico VA Hlth Care Syst, Med Serv, Albuquerque, NM 87108 USA.
EM anhoward@salud.unm.edu; acarrollportillo@salud.unm.edu;
   joalcock@salud.unm.edu; helin@salud.unm.edu
RI Carroll-Portillo, Amanda/GPS-4279-2022
OI Alcock, Joe/0000-0003-0807-164X; Carroll-Portillo,
   Amanda/0000-0001-9089-2601
FU Winkler Bacterial Overgrowth Research Fund, BRINM [217]; Interreg [217]
   Funding Source: Interreg
FX This work was funded by the Winkler Bacterial Overgrowth Research Fund,
   BRINM 217.
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NR 159
TC 2
Z9 2
U1 7
U2 10
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD AUG
PY 2024
VL 25
IS 16
AR 8690
DI 10.3390/ijms25168690
PG 16
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA E7J7X
UT WOS:001304738700001
PM 39201374
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Amato, GS
   Manke, A
   Harris, DL
   Wiethe, RW
   Vasukuttan, V
   Snyder, RW
   Lefever, TW
   Cortes, R
   Zhang, YN
   Wang, S
   Runyon, SP
   Maitra, R
AF Amato, George S.
   Manke, Amruta
   Harris, Danni L.
   Wiethe, Robert W.
   Vasukuttan, Vineetha
   Snyder, Rodney W.
   Lefever, Timothy W.
   Cortes, Ricardo
   Zhang, Yanan
   Wang, Shaobin
   Runyon, Scott P.
   Maitra, Rangan
TI Blocking Alcoholic Steatosis in Mice with a Peripherally Restricted
   Purine Antagonist of the Type 1 Cannabinoid Receptor
SO JOURNAL OF MEDICINAL CHEMISTRY
LA English
DT Article
ID INTERFERENCE COMPOUNDS PAINS; CRYSTAL-STRUCTURE; SURFACE-AREA; IN-VITRO;
   DOCKING; PERFORMANCE; PREDICTION; DISCOVERY; ASSAY; PHARMACOLOGY
AB Type 1 cannabinoid receptor (CB1) antagonists have demonstrated promise for the treatment of obesity, liver disease, metabolic syndrome, and dyslipidemias. However, the inhibition of CB1 receptors in the central nervous system can produce adverse effects, including depression, anxiety, and suicidal ideation. Efforts are now underway to produce peripherally restricted CB1 antagonists to circumvent CNS-associated undesirable effects. In this study, a series of analogues were explored in which the 4-aminopiperidine group of compound 2 was replaced with aryl- and heteroaryl-substituted piperazine groups both with and without a spacer. This resulted in mildly basic, potent antagonists of human CB1 (hCB1). The 2-chlorobenzyl piperazine, 25, was found to be potent (K-i = 8 nM); to be >1000-fold selective for hCB1 over hCB2; to have no hERG liability; and to possess favorable ADME properties including high oral absorption and negligible CNS penetration. Compound 25 was tested in a mouse model of alcohol-induced liver steatosis and found to be efficacious. Taken together, 25 represents an exciting lead compound for further clinical development or refinement.
C1 [Amato, George S.; Manke, Amruta; Harris, Danni L.; Wiethe, Robert W.; Vasukuttan, Vineetha; Snyder, Rodney W.; Lefever, Timothy W.; Cortes, Ricardo; Zhang, Yanan; Wang, Shaobin; Runyon, Scott P.; Maitra, Rangan] RTI Int, Discovery Sci & Technol, 3040 Cornwallis Rd, Res Triangle Pk, NC 27709 USA.
C3 Research Triangle Institute
RP Maitra, R (corresponding author), RTI Int, Discovery Sci & Technol, 3040 Cornwallis Rd, Res Triangle Pk, NC 27709 USA.
EM rmaitra@rti.org
OI Vasukuttan, Vineetha/0000-0001-9327-0955; Zhang,
   Yanan/0000-0001-7153-4358; Amato, George/0000-0002-3512-1895; Snyder,
   Rodney/0000-0001-5546-3158
FU NIH [AA022235, DK100414]
FX We express our gratitude to the NIDA drug-supply program for providing
   the radiolabeled probes and to Dr. Brian Thomas for supplying the CB1
   cells. We thank Keith Warner, Taylor Rosa, Elaine Gay, Aliah Hackney,
   and Melody Markley for excellent technical help. This research was
   funded by research grants AA022235 and DK100414 to R.M. from the NIH.
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NR 39
TC 26
Z9 28
U1 1
U2 8
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0022-2623
EI 1520-4804
J9 J MED CHEM
JI J. Med. Chem.
PD MAY 24
PY 2018
VL 61
IS 10
BP 4370
EP 4385
DI 10.1021/acs.jmedchem.7b01820
PG 16
WC Chemistry, Medicinal
WE Science Citation Index Expanded (SCI-EXPANDED); Index Chemicus (IC)
SC Pharmacology & Pharmacy
GA GH4VQ
UT WOS:000433403600008
PM 29688015
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Demiryürek, BE
   Emre, U
   Korucu, O
   Barut, BÖ
   Tasçilar, FN
   Atasoy, HT
   Demiryürek, E
   Yaylaci, S
   Genç, AB
AF Demiryurek, Bekir Enes
   Emre, Ufuk
   Korucu, Osman
   Barut, Banu Ozen
   Tascilar, Fatma Nida
   Atasoy, Huseyin Tugrul
   Demiryurek, Esra
   Yaylaci, Selcuk
   Genc, Ahmet Bilal
TI FREQUENCY AND TYPES OF HEADACHES IN PATIENTS WITH METABOLIC SYNDROME
SO IDEGGYOGYASZATI SZEMLE-CLINICAL NEUROSCIENCE
LA English
DT Article
DE metabolic syndrome; headache; migraine; obesity; triglyceride
ID BODY-MASS INDEX; MIGRAINE PREVALENCE; OBESE-PATIENTS; US ADULTS;
   POPULATION; EPIDEMIOLOGY; IMPACT
AB Background - Metabolic Syndrome (MetS) and headaches are common public health problems in whole world. The relationship between headaches and the MetS isn't understood clearly.
   Purpose - The aim of this study is to determine the prevalence and types of headaches, and evaluate the relationship between headache characteristics and clinical and laboratory parameters analyzed in patients diagnosed with MetS. Materials and methods Of the patients diagnosed with MetS in Endocrinology outpatient clinics between July 2011 and July 2012, 202 patients were included in the study. Hemoglobin, fasting blood glucose (FBG), total cholesterol, triglyceride, HDL and LDL cholesterol, thyroid function tests and HbA(1C) values of all patients were recorded. Beck Depression Inventory (BDI) and Beck Anxiety Inventory (BAI) were applied to all patients. The headache severity was assessed by Visual Analog Scale (VAS).
   Results - The prevalence of headache in patients with MetS was found to be 61.4%. The incidence of headache was higher in female patients (F: 86.4%, M: 13.6%). The distribution of the subtypes of headaches was as follows: Episodic Tension-TypeHeadaches (ETTH) 24.8%, Episodic Migraine 14.4%, Chronic Tension Type Headaches (CTTH) 11.3%, Episodic Tension-TypeHeadaches (ETTH) and Episodic Migraine 7.9%, and other types of headaches (Cervicogenic Headache and Cluster Headache) 3%. No statistically significant relationship was found between headache and non-headache groups in terms of body mass index, waist circumference, and the laboratory-parameters (p>0.05). The mean BDI and BAI scores were higher in the headache group (p<0.001 and p<0.001). No significant difference was found between the mean MIDAS scores in the subtypes of headaches (p=0.35). In the headache group, there was a significant relationship only between triglyceride levels and attack frequency, duration and severity.
   Conclusion - Prevalence of headache in patients with MetS was 61.4%. The incidence of subtypes of headaches was similar to those in the general population. A relationship was found between triglyceride levels and attack frequency and severity. The result may be important to draw attention to the evaluation of triglyceride levels for reducing the frequency and severity of attacks in patients with headaches.
C1 [Demiryurek, Bekir Enes] Sakarya Educ & Res Hosp, Dept Neurol, TR-54600 Sakarya, Turkey.
   [Emre, Ufuk; Barut, Banu Ozen; Tascilar, Fatma Nida; Atasoy, Huseyin Tugrul] Kecioren Educ & Res Hosp, Dept Neurol, TR-06300 Ankara, Turkey.
   [Korucu, Osman] Bulent Ecevit Univ, Fac Med, Dept Neurol, TR-67300 Zonguldak, Turkey.
   [Demiryurek, Esra] Sakarya Educ & Res Hosp, Dept Psychiat, TR-54600 Sakarya, Sakarya, Turkey.
   [Yaylaci, Selcuk] Rize Findikli State Hosp, Dept Internal Med, Rize, Turkey.
   [Genc, Ahmet Bilal] Sakarya Educ & Res Hosp, Dept Internal Med, TR-54600 Sakarya, Sakarya, Turkey.
C3 Sakarya Training & Research Hospital; Ankara Kecioren Training &
   Research Hospital; Zonguldak Bulent Ecevit University; Sakarya Training
   & Research Hospital; Rize Findikli Region Goiter Research & Treatment
   Center; Sakarya Training & Research Hospital
RP Demiryürek, BE (corresponding author), Sakarya Educ & Res Hosp, Dept Neurol, TR-54600 Sakarya, Turkey.
EM bekirenes@mynet.com
RI demiryürek, esra/IZP-9856-2023; korucu, osman/AAV-9585-2021; Yaylacı,
   Selcuk/ABF-7883-2022; Atasoy, Hüseyin/AIA-4694-2022; ozen,
   banu/ABI-8008-2020; Genc, Ahmed Bilal/JCE-6100-2023
OI Demiryurek, Bekir Enes/0000-0003-4221-2506; ATASOY, HUSEYIN
   TUGRUL/0000-0003-1631-7400
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NR 29
TC 2
Z9 2
U1 0
U2 11
PU LITERATURA MEDICA
PI BUDAPEST
PA MARGIT KRT 31-33, BUDAPEST, 1024, HUNGARY
SN 0019-1442
J9 IDEGGYOGY SZEMLE
JI Ideggyogy. Szle.
PD SEP 30
PY 2016
VL 69
IS 9-10
BP 319
EP 325
DI 10.18071/isz.69.0319
PG 7
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA DX8JA
UT WOS:000384632700005
PM 29638097
DA 2025-06-11
ER

PT J
AU Sharifi-Rad, J
   Quetglas-Llabres, MM
   Sureda, A
   Mardones, L
   Villagran, M
   Gürer, ES
   Zivkovic, J
   Ezzat, SM
   Zayed, A
   Gümüsok, S
   Kiliç, CS
   Fasipe, B
   Laher, I
   Martorell, M
AF Sharifi-Rad, Javad
   Quetglas-Llabres, Maria Magdalena
   Sureda, Antoni
   Mardones, Lorena
   Villagran, Marcelo
   Gurer, Eda Sonmez
   Zivkovic, Jelena
   Ezzat, Shahira M.
   Zayed, Ahmed
   Gumusok, Safa
   Kilic, Ceyda Sibel
   Fasipe, Babatunde
   Laher, Ismail
   Martorell, Miquel
TI Supercharging metabolic health with Lycium barbarum L.: A review
   of the therapeutic potential of this functional food for managing
   metabolic syndrome
SO FOOD FRONTIERS
LA English
DT Review
DE goji; immune system; Lycium barbarum; metabolic syndrome; oxidative
   stress; polysaccharides
ID INDUCED OXIDATIVE STRESS; HYPOGLYCEMIC ACTIVITY; GUT MICROBIOTA; GOJI
   BERRY; POLYSACCHARIDES; ANTIOXIDANT; FRUIT; PATHOPHYSIOLOGY; MODULATION;
   EXTRACTION
AB Metabolic syndrome (MetS) is a common disorder involving a cluster of metabolic abnormalities, such as abdominal obesity, hypertension, dyslipidemia, insulin resistance, and atherogenic profile. MetS is characterized by an increase in oxidative stress and a chronic proinflammatory state, which are directly related to the development and progression of this pathology. It has been seen how a healthy lifestyle and good dietary practices are key to improving the different metabolic parameters and, therefore, play a fundamental role in reducing the risk of developing diabetes. The present review focuses on the research evidence related to the therapeutic properties of Lycium barbarum L. in MetS gathered in the last years. Several preclinical studies suggest that L. barbarum extracts are a good dietary supplement for the prevention of cardiovascular diseases in people with MetS. This compound has been used for years in traditional Chinese medicine for the treatment of atrophic gastritis, problems related to the lungs, kidneys, and liver, and as a supplement for eye health. In addition, different in vitro and in vivo studies have been carried out that support the properties attributed to metabolites derived from L. barbarum, such as polysaccharides that have been shown diverse biological activities. In conclusion, L. barbarum extracts have multiple benefits to increase general well-being and immune function. However, there are a limited number of studies related to effect of L. barbarum in MetS, but they demonstrated effectiveness in the treatment of obesity, diabetes mellitus type 2, and prevention of diabetes mellitus type 2 complication.
C1 [Sharifi-Rad, Javad] Univ Azuay, Fac Med, Cuenca, Ecuador.
   [Quetglas-Llabres, Maria Magdalena; Sureda, Antoni] Univ Balear Isl IUNICS, Res Grp Community Nutr & Oxidat Stress, Palma De Mallorca, Mallorca, Spain.
   [Quetglas-Llabres, Maria Magdalena; Sureda, Antoni] Univ Balear Isl IUNICS, Hlth Res Inst Balear Isl IdISBa, Palma De Mallorca, Mallorca, Spain.
   [Sureda, Antoni] Inst Salud Carlos III, CIBEROBN Physiopathol Obes & Nutr, Madrid, Spain.
   [Mardones, Lorena; Villagran, Marcelo] Univ Catolica Santisima Concepcion, Fac Med, Dept Basic Sci, Concepcion, Chile.
   [Villagran, Marcelo; Gurer, Eda Sonmez] Univ Catolica Santisima Concepcion, Sci Technol Ctr Sustainable Dev Coastline, Concepcion, Chile.
   Sivas Cumhuriyet Univ, Fac Pharm, Dept Pharmacognosy, Sivas, Turkiye.
   [Zivkovic, Jelena] Inst Med Plant Res Dr Josif Pancic, Tadeusa Koscuska 1, Belgrade, Serbia.
   [Ezzat, Shahira M.] Cairo Univ, Fac Pharm, Dept Pharmacognosy, Cairo, Egypt.
   [Ezzat, Shahira M.] October Univ Modern Sci & Arts MSA, Fac Pharm, Dept Pharmacognosy, 6th Of October, Egypt.
   [Zayed, Ahmed; Kilic, Ceyda Sibel] Tanta Univ, Coll Pharm, Dept Pharmacognosy, Tanta 8130, Egypt.
   [Gumusok, Safa] Ankara Univ, Fac Pharm, Dept Pharmaceut Bot, Ankara, Turkiye.
   [Fasipe, Babatunde] Bowen Univ, Fac Basic Med Sci, Dept Pharmacol & Therapeut, Iwo, Nigeria.
   [Laher, Ismail] Univ British Columbia, Fac Med, Dept Anesthesiol Pharmacol & Therapeut, Vancouver, BC, Canada.
   [Martorell, Miquel] Univ Concepcion, Fac Pharm, Dept Nutr & Dietet, Concepcion, Chile.
   [Martorell, Miquel] Univ Concepcion, Ctr Hlth Living, Concepcion, Chile.
   [Sharifi-Rad, Javad] Shahid Beheshti Univ Med Sci, Phytochem Res Ctr, Tehran, Iran.
C3 Universidad del Azuay; Institut Investigacio Sanitaria Illes Balears
   (IdISBa); CIBER - Centro de Investigacion Biomedica en Red; CIBEROBN;
   Instituto de Salud Carlos III; Universidad Catolica de la Santisima
   Concepcion; Universidad Catolica de la Santisima Concepcion; Cumhuriyet
   University; Egyptian Knowledge Bank (EKB); Cairo University; Egyptian
   Knowledge Bank (EKB); Modern Sciences & Arts University (MSA); Egyptian
   Knowledge Bank (EKB); Tanta University; Ankara University; University of
   British Columbia; Universidad de Concepcion; Universidad de Concepcion;
   Shahid Beheshti University Medical Sciences
RP Martorell, M (corresponding author), Univ Concepcion, Fac Pharm, Dept Nutr & Dietet, Concepcion, Chile.; Martorell, M (corresponding author), Univ Concepcion, Ctr Hlth Living, Concepcion, Chile.; Sharifi-Rad, J (corresponding author), Shahid Beheshti Univ Med Sci, Phytochem Res Ctr, Tehran, Iran.
EM javad.sharifirad@gmail.com; mmartorell@udec.cl
RI Sureda, Antoni/N-9588-2019; Fasipe, Babatunde/IVV-2011-2023; Laher,
   Ismail/L-3947-2013; Zayed, Ahmed/ABC-7238-2021; Ezzat,
   Shahira/AAJ-3122-2021; Quetglas Llabrés, Maria/AAA-4412-2019; Mardones,
   Lorena/HHS-7166-2022; Villagran, Marcelo/AAP-1171-2020; Martorell,
   Miquel/H-8490-2014; Sharifi-Rad, Javad/D-5747-2016; Kilic, Ceyda
   Sibel/F-8057-2014; Sonmez Gurer, Eda/HHZ-0907-2022
OI Martorell, Miquel/0000-0003-3183-7623; Sharifi-Rad,
   Javad/0000-0002-7301-8151; Zivkovic, Jelena/0000-0002-9684-2637; Kilic,
   Ceyda Sibel/0000-0003-2905-7628; Sonmez Gurer, Eda/0000-0003-0319-6312
FU Instituto de Salud Carlos [CIBEROBN CB12/03/30038]
FX Instituto de Salud Carlos, Grant/Award Number: CIBEROBNCB12/03/30038
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NR 113
TC 4
Z9 4
U1 7
U2 23
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
EI 2643-8429
J9 FOOD FRONTIERS
JI Food Frontiers
PD MAR
PY 2024
VL 5
IS 2
BP 420
EP 434
DI 10.1002/fft2.327
EA JAN 2024
PG 15
WC Food Science & Technology
WE Emerging Sources Citation Index (ESCI)
SC Food Science & Technology
GA LG4S8
UT WOS:001139603200001
OA gold
DA 2025-06-11
ER

PT J
AU Molinar-Toribio, E
   Pérez-Jiménez, J
   Ramos-Romero, S
   Romeu, M
   Giralt, M
   Taltavull, N
   Muñoz-Cortes, M
   Jáuregui, O
   Méndez, L
   Medina, I
   Torres, JL
AF Molinar-Toribio, Eunice
   Perez-Jimenez, Jara
   Ramos-Romero, Sara
   Romeu, Marta
   Giralt, Montserrat
   Taltavull, Nuria
   Munoz-Cortes, Monica
   Jauregui, Olga
   Mendez, Lucia
   Medina, Isabel
   Lluis Torres, Josep
TI Effect of n-3 PUFA supplementation at different EPA:DHA ratios on
   the spontaneously hypertensive obese rat model of the metabolic syndrome
SO BRITISH JOURNAL OF NUTRITION
LA English
DT Article
DE Metabolic syndrome; n-3 PUFA; Spontaneously hypertensive obese rats;
   EPA/DHA
ID C-REACTIVE PROTEIN; INSULIN-RESISTANCE; DOCOSAHEXAENOIC ACID; FISH-OIL;
   EICOSAPENTAENOIC ACID; INFLAMMATION; OMEGA-3-FATTY-ACIDS;
   F-2-ISOPROSTANES; GLUTATHIONE; MECHANISMS
AB The increasing incidence of the metabolic syndrome (MetS), a combination of risk factors before the onset of CVD and type 2 diabetes, encourages studies on the role of functional food components such as long-chain n-3 PUFA as preventive agents. In the present study, we explore the effect of EPA and DHA supplementation in different proportions on spontaneously hypertensive obese (SHROB) rats, a model for the MetS in a prediabetic state with mild oxidative stress. SHROB rats were randomised into four groups (n 7), each supplemented with EPA/DHA at ratios of 1:1, 2:1 and 1:2, or soyabean oil as the control for 13 weeks. The results showed that in all the proportions tested, EPA/DHA supplementation significantly lowered total and LDL-cholesterol concentrations, compared with those of the control group. EPA/DHA supplementation at the ratios of 1:1 and 2:1 significantly decreased inflammation (C-reactive protein levels) and lowered oxidative stress (decreased excretion of urinary isoprostanes), mainly at the ratio of 1:2. The activity of antioxidant enzymes increased in erythrocytes, abdominal fat and kidneys, with magnitudes depending on the EPA: DHA ratio. PUFA mixtures from fish affected different MetS markers of CVD risk factors in SHROB rats, depending on the ratios of EPA/DHA supplementation. The activation of endogenous defence systems may be related to the reduction of inflammation and oxidative stress.
C1 [Molinar-Toribio, Eunice; Perez-Jimenez, Jara; Ramos-Romero, Sara; Lluis Torres, Josep] Inst Adv Chem Catalonia IQAC CSIC, Barcelona, Spain.
   [Ramos-Romero, Sara] Biomed Res Networking Ctr Bioengn Biomat & Nanome, Zaragoza, Spain.
   [Romeu, Marta; Giralt, Montserrat; Taltavull, Nuria; Munoz-Cortes, Monica] Univ Rovira & Virgili, Unidad Farmacol, Fac Med & Ciencias Salud, E-43201 Reus, Spain.
   [Jauregui, Olga] Univ Barcelona CCiT UB, Sci & Technol Ctr, Barcelona, Spain.
   [Mendez, Lucia; Medina, Isabel] CSIC, Inst Invest Marinas, Vigo, Spain.
C3 Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Centro de
   Investigacion y Desarrollo Pascual Vila (CID-CSIC); CSIC - Instituto de
   Quimica Avanzada de Cataluna (IQAC); CIBER - Centro de Investigacion
   Biomedica en Red; CIBERBBN; Universitat Rovira i Virgili; University of
   Barcelona; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC
   - Instituto de Investigaciones Marinas (IIM)
RP Pérez-Jiménez, J (corresponding author), Inst Adv Chem Catalonia IQAC CSIC, Barcelona, Spain.
EM jara.perez@ictan.csic.es
RI MEDINA, ISABEL/AAL-4012-2021; Perez-Jimenez, Jara/B-3989-2009;
   Ramos-Romero, Sara/AAH-6209-2020; ROMEU, MARTA/O-7129-2019; Torres,
   Josep/N-7256-2013; Mendez, Lucia/T-7016-2017; Ramos-Romero,
   Sara/K-8301-2017; ROMEU, MARTA/A-8468-2014; Montserrat,
   Giralt/I-3905-2015
OI Torres, Josep/0000-0002-5072-8265; Molinar-Toribio,
   Eunice/0000-0001-8870-6849; Jauregui, Olga/0000-0002-5834-3829; Mendez,
   Lucia/0000-0002-9711-2994; Perez-Jimenez, Jara/0000-0002-2811-4558;
   Ramos-Romero, Sara/0000-0002-9293-4454; Taltavull,
   Nuria/0000-0002-3340-2650; ROMEU, MARTA/0000-0002-2131-1858; MEDINA,
   ISABEL/0000-0002-1854-3359; Montserrat, Giralt/0000-0002-7073-577X
FU Spanish Ministry of Science and Innovation and of Economy and
   Competitiveness [AGL2009-12374-C03-01, AGL2009-12374-C03-02,
   AGL2009-12374-C03-03, AGL2013-49079-C2-1-R, AGL2013-49079-C2-2-R];
   Panamanian Government (SENACYT/IFARHU); Spanish Ministry of Science and
   Innovation; ISCIII [CD09/00068]
FX The present study work was supported by the Spanish Ministry of Science
   and Innovation and of Economy and Competitiveness (grant no.
   AGL2009-12374-C03-01, -02 and -03; AGL2013-49079-C2-1,2-R,
   respectively). The authors acknowledge the Panamanian Government
   (SENACYT/IFARHU) and the Spanish Ministry of Science and Innovation for
   their predoctoral fellowships to E. M.-T. and L. M., respectively. They
   also acknowledge ISCIII for the postdoctoral contract 'Sara Borrell' to
   J. P.-J. (CD09/00068). None of the funders had any role in the design,
   analysis and findings of the study or in the writing of this article.
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NR 42
TC 41
Z9 45
U1 0
U2 40
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1145
EI 1475-2662
J9 BRIT J NUTR
JI Br. J. Nutr.
PD MAR 28
PY 2015
VL 113
IS 6
BP 878
EP 887
DI 10.1017/S0007114514004437
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA CF7CD
UT WOS:000352712800002
PM 25720761
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Rajabi, S
   Darroudi, M
   Naseri, K
   Farkhondeh, T
   Samarghandian, S
AF Rajabi, Shahnaz
   Darroudi, Majid
   Naseri, Kobra
   Farkhondeh, Tahereh
   Samarghandian, Saeed
TI Protective Effects of Curcumin and its Analogues via the Nrf2
   Pathway in Metabolic Syndrome
SO CURRENT MEDICINAL CHEMISTRY
LA English
DT Review
DE curcumin; Nrf2 pathway; metabolic syndrome; diabetes; hypertension;
   obesity
ID SYMPATHETIC-NERVOUS-SYSTEM; INCREASED OXIDATIVE STRESS; FREE
   FATTY-ACIDS; NF-KAPPA-B; INSULIN-RESISTANCE; ABDOMINAL OBESITY;
   DIHYDROMYRICETIN; ANTIOXIDANT; IMPACT; MITOCHONDRIA
AB Metabolic Syndrome (MetS) refers to a set of medical conditions including insulin resistance, central obesity, atherogenic dyslipidemia, and hypertension. Due to these dysregulations, if not treated, MetS could increase the risk of CVA, CVD, and diabetes. As described by WHO, CVD is the leading cause of mortality in the world which motivates researchers to investigate the management of its risk factors, especially MetS. It is reported that oxidative stress secondary to the abundant generation of free radicals oxygen species (ROS) and the ensuing altered redox status play an important role as a mediator in MetS. As a result, using new antioxidant agents with higher bioavailability has been proposed as an efficient treatment. Curcumin (a polyphenol of the diarylheptanoids class), which is used as a traditional medicine for various diseases including cardiovascular diseases and diabetes, is characterized by its antioxidant properties which, at least in part, are mediated via the activation of the Nrf2/ARE signaling pathway. Nrf2 is a transcription factor that plays a key role in regulating internal defense systems and increases antioxidant levels to decrease oxidative damage and cell apoptosis. Nrf2 expression and stability are enhanced by curcumin, leading to a higher rate of Nrf2 migration to the cell nucleus to regulate ARE gene expression, thus protecting cells against oxidative stress. In this article, we provide a comprehensive review of the molecular effect of curcumin and its derivatives via Nrf2 regulation in several conditions, such as diabetes, hypertension, dyslipidemia, and obesity.
C1 [Rajabi, Shahnaz] Birjand Univ Med Sci, Student Res Comm, Birjand, Iran.
   [Darroudi, Majid] Neyshabur Univ Med Sci, Dept Basic Sci, Neyshabur 9318614139, Iran.
   [Naseri, Kobra; Farkhondeh, Tahereh] Birjand Univ Med Sci, Sch Pharm, Dept Toxicol & Pharmacol, Birjand, Iran.
   [Samarghandian, Saeed] Neyshabur Univ Med Sci, Hlth Ageing Res Ctr, Neyshabur, Iran.
C3 Birjand University of Medical Sciences; Birjand University of Medical
   Sciences
RP Farkhondeh, T (corresponding author), Birjand Univ Med Sci, Sch Pharm, Dept Toxicol & Pharmacol, Birjand, Iran.; Samarghandian, S (corresponding author), Neyshabur Univ Med Sci, Hlth Ageing Res Ctr, Neyshabur, Iran.
EM farkhondeh2324@gmail.com; samarghandians1@nums.ac.ir
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NR 79
TC 3
Z9 3
U1 0
U2 6
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 0929-8673
EI 1875-533X
J9 CURR MED CHEM
JI Curr. Med. Chem.
PY 2024
VL 31
IS 25
BP 3966
EP 3976
DI 10.2174/0929867330666230510101150
EA JUL 2023
PG 11
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Pharmacology &
   Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
GA YS8E6
UT WOS:001038099200001
PM 37218198
DA 2025-06-11
ER

PT J
AU Papafotiou, C
   Christaki, E
   van den Akker, ELT
   Wester, VL
   Apostolakou, F
   Papassotiriou, I
   Chrousos, GP
   Pervanidou, P
AF Papafotiou, Chrysanthe
   Christaki, Eirini
   van den Akker, Erica L. T.
   Wester, Vincent L.
   Apostolakou, Filia
   Papassotiriou, Ioannis
   Chrousos, George P.
   Pervanidou, Panagiota
TI Hair cortisol concentrations exhibit a positive association with
   salivary cortisol profiles and are increased in obese prepubertal girls
SO STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS
LA English
DT Article
DE Hair cortisol; salivary cortisol; childhood obesity;
   hypothalamic-pituitary-adrenal axis; metabolic syndrome; inflammation
ID BODY-MASS INDEX; METABOLIC SYNDROME; STRESS; OVERWEIGHT; CHILDHOOD;
   BIOMARKER; SERUM
AB Cortisol, a key mediator of the stress response, has been associated with obesity and metabolic syndrome manifestations as early as in childhood. Scalp hair cortisol has been proposed as a reliable index of long-term circulating cortisol. We aimed to investigate whether obese prepubertal girls have higher scalp hair cortisol than normal-weight controls and whether hair cortisol levels are correlated with salivary cortisol concentrations in these groups. In this cross-sectional study, 25 obese girls and 25 normal-weighted, age-matched girls were enrolled. Anthropometric evaluation, blood chemistry and salivary cortisol measurements were performed, and body mass index (BMI) and areas under the curve with respect to ground (AUCg) were calculated. Hair cortisol determination was performed with liquid chromatography-tandem mass spectrometry. Both hair cortisol concentrations and salivary cortisol AUCs were higher in the obese than the normal-weight girls (p<.001 and p=.002, respectively). A positive correlation between hair cortisol and BMI Z-score was found (rho=.327, p=.025), while hair cortisol correlated positively with salivary cortisol AUCg (rho=.3, p=.048). We conclude that obese prepubertal girls have higher hair and salivary cortisol concentrations than their age-matched lean counterparts. Hair cortisol assessment seems to be a sensitive method of evaluating systemic cortisol exposure, which is supported by our finding that hair cortisol is associated with salivary concentrations of the hormone.Lay Summary: Cortisol is the key hormone of the stress response. Childhood obesity has been associated with cortisol production dysregulation. Our findings suggest a positive association between obesity in prepubertal girls and elevated cortisol concentrations, measured in saliva and hair.
C1 [Papafotiou, Chrysanthe; Christaki, Eirini; Chrousos, George P.; Pervanidou, Panagiota] Natl & Kapodistrian Univ Athens, Sch Med, Aghia Sophia Childrens Hosp, Dept Pediat 1, Thivon & Levadias Str, Athens 11527, Greece.
   [van den Akker, Erica L. T.] Univ Med Ctr Rotterdam, Erasmus MC, Dept Pediat, Rotterdam, Netherlands.
   [Wester, Vincent L.] Univ Med Ctr Rotterdam, Erasmus MC, Dept Internal Med, Rotterdam, Netherlands.
   [Apostolakou, Filia; Papassotiriou, Ioannis] Aghia Sophia Childrens Hosp, Dept Clin Biochem, Athens, Greece.
C3 National & Kapodistrian University of Athens; Athens Medical School; The
   Aghia Sophia Children's Hospital; Erasmus University Rotterdam; Erasmus
   MC; Erasmus University Rotterdam; Erasmus MC; The Aghia Sophia
   Children's Hospital
RP Papafotiou, C (corresponding author), Natl & Kapodistrian Univ Athens, Sch Med, Aghia Sophia Childrens Hosp, Dept Pediat 1, Thivon & Levadias Str, Athens 11527, Greece.
EM chryspapafotiou@gmail.com
RI Pervanidou, Panagiota/ABI-6356-2020; Chrousos, George/G-8702-2011
OI Pervanidou, Panagiota/0000-0002-6593-6489; Christaki,
   Eirini/0000-0002-9977-588X
FU National and Kapodistrian University of Athens
FX Funding for this work was received from the National and Kapodistrian
   University of Athens.
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NR 20
TC 44
Z9 45
U1 2
U2 31
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1025-3890
EI 1607-8888
J9 STRESS
JI Stress
PD MAR
PY 2017
VL 20
IS 2
BP 217
EP 222
DI 10.1080/10253890.2017.1303830
PG 6
WC Behavioral Sciences; Endocrinology & Metabolism; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Behavioral Sciences; Endocrinology & Metabolism; Neurosciences &
   Neurology
GA ES5AP
UT WOS:000399548500012
PM 28270027
DA 2025-06-11
ER

PT J
AU Takeshita, Y
   Watanabe, S
   Hattori, T
   Nagasawa, K
   Matsuura, N
   Takahashi, K
   Murohara, T
   Nagata, K
AF Takeshita, Yuuri
   Watanabe, Shogo
   Hattori, Takuya
   Nagasawa, Kai
   Matsuura, Natsumi
   Takahashi, Keiji
   Murohara, Toyoaki
   Nagata, Kohzo
TI Blockade of glucocorticoid receptors with RU486 attenuates cardiac
   damage and adipose tissue inflammation in a rat model of metabolic
   syndrome
SO HYPERTENSION RESEARCH
LA English
DT Article
DE adipose tissue; cardiac remodeling; glucocorticoid receptor; glucose
   metabolism; metabolic syndrome
ID 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1; MINERALOCORTICOID RECEPTOR;
   DIASTOLIC DYSFUNCTION; CARDIOMYOCYTE HYPERTROPHY; OXIDATIVE STRESS;
   ANIMAL-MODEL; OBESITY; EXPRESSION; HEART; ALDOSTERONE
AB Glucocorticoids are stress hormones that modulate metabolic, inflammatory and cardiovascular processes. We recently characterized DahlS. Z-Leprfa/Leprfa (DS/obese) rats, derived from a cross between Dahl salt-sensitive (DS) and Zucker rats, as a new animal model of metabolic syndrome (MetS). We have now investigated the effects of glucocorticoid receptor (GR) blockade on cardiac and adipose tissue pathology and gene expression, as well as on glucose metabolism in this model. DS/obese rats were treated with the GR blocker RU486 (2 mg kg(-1) per day, subcutaneous) for 4 weeks beginning at 9 weeks of age. Age-matched homozygous lean (DahlS. Z-Lepr(+)/Lepr(+), or DS/lean) littermates of DS/obese rats served as controls. Treatment of DS/obese rats with RU486 attenuated left ventricular (LV) fibrosis and diastolic dysfunction, as well as cardiac oxidative stress and inflammation, without affecting hypertension or LV hypertrophy. Administration of RU486 to DS/obese rats also inhibited the upregulation of GR and 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1) expression at the mRNA and protein levels in the heart; it attenuated adiposity and adipose tissue inflammation, as well as the upregulation of GR and 11 beta-HSD1 mRNA and protein expression in adipose tissue; it ameliorated fasting hyperinsulinemia as well as insulin resistance and glucose intolerance. Our results thus implicate the glucocorticoid-GR axis in the pathophysiology of MetS, and they suggest that GR blockade has therapeutic potential for the treatment of this condition.
C1 [Takeshita, Yuuri; Watanabe, Shogo; Hattori, Takuya; Nagasawa, Kai; Matsuura, Natsumi; Takahashi, Keiji; Nagata, Kohzo] Nagoya Univ, Grad Sch Med, Dept Pathophysiol Lab Sci, Nagoya, Aichi 4618673, Japan.
   [Murohara, Toyoaki] Nagoya Univ, Grad Sch Med, Dept Cardiol, Nagoya, Aichi 4618673, Japan.
C3 Nagoya University; Nagoya University
RP Nagata, K (corresponding author), Nagoya Univ, Grad Sch Med, Dept Pathophysiol Lab Sci, Higashi Ku, 1-1-20 Daikominami, Nagoya, Aichi 4618673, Japan.
EM nagata@met.nagoya-u.ac.jp
RI Murohara, Toyoaki/M-4958-2014
FU Ministry of Education, Culture, Sports, Science, and Technology of Japan
   [24590690]; Grants-in-Aid for Scientific Research [24590690] Funding
   Source: KAKEN
FX We thank Dr Hiromi Ito and Sae Ohura for technical assistance. This work
   was supported by a grant from the Ministry of Education, Culture,
   Sports, Science, and Technology of Japan (no. 24590690 to KN).
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NR 54
TC 27
Z9 30
U1 0
U2 12
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0916-9636
EI 1348-4214
J9 HYPERTENS RES
JI Hypertens. Res.
PD NOV
PY 2015
VL 38
IS 11
BP 741
EP 750
DI 10.1038/hr.2015.77
PG 10
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA CV9CE
UT WOS:000364584100007
PM 26155752
OA Bronze
DA 2025-06-11
ER

PT J
AU Nakajima, K
   Takeishi, Y
   Matsuo, S
   Yamasaki, Y
   Nishimura, T
AF Nakajima, Kenichi
   Takeishi, Yasuchika
   Matsuo, Shinro
   Yamasaki, Yoshimitsu
   Nishimura, Tsunehiko
TI Metabolic syndrome is not a predictor for cardiovascular events in
   Japanese patients with diabetes mellitus asymptomatic for coronary
   artery disease: A retrospective analysis of the J-ACCESS-2 study
SO JOURNAL OF NUCLEAR CARDIOLOGY
LA English
DT Article
DE Metabolic syndrome; type 2 diabetes; myocardial perfusion imaging; SPECT
   imaging; prognosis
ID RISK STRATIFICATION; HEART-DISEASE; POPULATION
AB Purpose. Patients with metabolic syndrome (MetS) have potentially higher risk for cardiovascular events. The aim of this study was to evaluate the effect of MetS on cardiac events in type-2 diabetic patients asymptomatic for coronary artery disease (CAD) in a Japanese population.
   Methods. A total of 485 patients from a J-ACCESS-2 investigation with stress-gated myocardial perfusion imaging (MPI) and quantitative-gated MPI analysis were examined. Cardiovascular hard events (cardiac death and acute coronary syndrome) and total events during a 3-year follow-up were analyzed.
   Results. The MetS group (n = 229) had higher incidence of hypertension, dyslipidemia, and ventricular dilatation than the non-MetS group (n = 256). The hard events were 8 and 12 for the MetS and non-MetS groups (P = n.s.), and total events were 31 and 31 for each of these groups, respectively (P = n.s.). Significant variables related to total cardiovascular events included age, current smoking, insulin use, total cholesterol, ejection fraction, summed stress score >= 9, and summed difference score >= 2. Cox proportional hazard analysis and Kaplan-Meier survival analysis showed that only the summed stress score was related to total events (P = .01), and the presence and the number of items for MetS criteria were not.
   Conclusion. In patients with type 2 diabetes asymptomatic for CAD, cardiovascular events and ischemia are as common in diabetic patients without MetS as in those with MetS. A high MPI defect score is related to total events including cardiac and cerebrovascular events. (J Nucl Cardiol 2013;20:234-41.)
C1 [Nakajima, Kenichi; Matsuo, Shinro] Kanazawa Univ Hosp, Dept Nucl Med, Kanazawa, Ishikawa 9208641, Japan.
   [Takeishi, Yasuchika] Fukushima Med Univ, Dept Cardiol & Hematol, Fukushima, Japan.
   [Yamasaki, Yoshimitsu] Osaka Univ, Dept Endocrinol & Metab, Suita, Osaka, Japan.
   [Nishimura, Tsunehiko] Kyoto Prefectural Univ Med, Dept Radiol, Kyoto, Japan.
C3 Kanazawa University; Fukushima Medical University; The University of
   Osaka; Kyoto Prefectural University of Medicine
RP Nakajima, K (corresponding author), Kanazawa Univ Hosp, Dept Nucl Med, 13-1 Takara Machi, Kanazawa, Ishikawa 9208641, Japan.
EM nakajima@med.kanazawa-u.ac.jp
FU Japan Cardiovascular Research Foundation; JSPS in Japan [22591320];
   Grants-in-Aid for Scientific Research [23591755, 22591320] Funding
   Source: KAKEN
FX This study was mainly supported by the Japan Cardiovascular Research
   Foundation, and in part by JSPS Grants-in-Aid for Scientific Research
   (C) Grant Number 22591320 in Japan. The authors thank Mr. Ronald Belisle
   for editorial assistance.
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NR 20
TC 5
Z9 6
U1 0
U2 3
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1071-3581
EI 1532-6551
J9 J NUCL CARDIOL
JI J. Nucl. Cardiol.
PD APR
PY 2013
VL 20
IS 2
BP 234
EP 241
DI 10.1007/s12350-012-9656-0
PG 8
WC Cardiac & Cardiovascular Systems; Radiology, Nuclear Medicine & Medical
   Imaging
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Radiology, Nuclear Medicine &
   Medical Imaging
GA 107AO
UT WOS:000316187200009
PM 23196975
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Kagota, S
   Maruyama, K
   Wakuda, H
   McGuire, JJ
   Yoshikawa, N
   Nakamura, K
   Shinozuka, K
AF Kagota, Satomi
   Maruyama, Kana
   Wakuda, Hirokazu
   McGuire, John J.
   Yoshikawa, Noriko
   Nakamura, Kazuki
   Shinozuka, Kazumasa
TI Disturbance of vasodilation via protease-activated receptor 2 in
   SHRSP.Z-Lepr<SUP>fa</SUP>/IzmDmcr rats with metabolic syndrome
SO VASCULAR PHARMACOLOGY
LA English
DT Article
DE Endothelium dysfunction; Metabolic syndrome; Obesity; Protease-activated
   receptor 2; Nitric oxide
ID HUMAN CORONARY-ARTERY; DIET-INDUCED OBESITY; IN-VIVO; ADIPOSE
   INFLAMMATION; BLOOD PRESSURES; ANIMAL-MODEL; EXPRESSION; ARTERIOLES;
   MECHANISMS; STRESS
AB Protease-activated receptor-2 (PAR2) activation causes vascular inflammation and vasodilation, but its role in metabolic syndrome (MetS) remains uncertain. Therefore, we examined whether the PAR2-induced vasodilation of SHRSP.Z-Lepr(fa)/IzmDmcr rats (SHRSP.ZF) is impaired and if so, whether administering telmisartan is protective.
   PAR2-activating peptide, 2-furoyl-LIGRLO-amide (2fly), relaxed the isolated superior and first-order branches of mesenteric arteries (MAs) from Wistar-Kyoto rats (WKY) and SHRSP.ZF. Superior-MA relaxation by 2fly was less in SHRSP.ZF than in WKY. Relaxation of first-order MAs by 2fly was the same in SHRSP.ZF and WKY. NO synthase inhibitor partially reduced 2fly-induced relaxation of superior and first-order MAs in SHRSP.ZF and MY; inhibition of relaxation was proportionately larger in SHRSP.ZF. In SHRSP.ZF, nitroprusside-induced relaxation and the expression of soluble guanylyl cyclase decreased. In SHRSP.ZF, telmisartan reversed these abnormalities, and decreased blood pressure and serum levels of thiobarbituric acid reactive substances, an index of oxidative stress. Vasodilation via PAR2 activation was preserved in small-caliber MAs, in contrast to large-caliber MAs, even when MetS reduced NO-dependent relaxation mechanisms. NO and non-NO relaxing factor(s) contributed to PAR2-mediated relaxation in MAs, and the balance between factors may be altered to preserve vasodilation in MetS. Telmisartan prevented vascular dysfunction in MetS by protecting arteries against oxidative stress. (C) 2014 Elsevier Inc. All rights reserved.
C1 [Kagota, Satomi; Maruyama, Kana; Wakuda, Hirokazu; Yoshikawa, Noriko; Nakamura, Kazuki; Shinozuka, Kazumasa] Mukogawa Womens Univ, Sch Pharm & Pharmaceut Sci, Dept Pharmacol, Nishinomiya, Hyogo, Japan.
   [McGuire, John J.] Mem Univ Newfoundland, Div Biomed Sci, Cardiovasc Res Grp, St John, NF, Canada.
C3 Mukogawa Women's University; Memorial University Newfoundland
RP Kagota, S (corresponding author), 11-68 Koshien Kyuban Cho, Nishinomiya, Hyogo 6638179, Japan.
EM skagota@mukogawa-u.ac.jp
RI Wakuda, Hirokazu/KZU-6319-2024
OI Wakuda, Hirokazu/0000-0002-5717-8251; McGuire, John/0000-0003-0302-3884
FU MEXT KAKENHI [23590315]; Grants-in-Aid for Scientific Research
   [23590315] Funding Source: KAKEN
FX This research was partly supported by MEXT KAKENHI (grant number
   23590315). We thank Ms. Yasuko Mino for technical assistance.
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NR 42
TC 13
Z9 16
U1 0
U2 3
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1537-1891
EI 1879-3649
J9 VASC PHARMACOL
JI Vasc. Pharmacol.
PD OCT
PY 2014
VL 63
IS 1
BP 46
EP 54
DI 10.1016/j.vph.2014.06.005
PG 9
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA AR1LT
UT WOS:000343347400007
PM 25109437
DA 2025-06-11
ER

PT J
AU Bhatti, SK
   O'Keefe, JH
   Lavie, CJ
AF Bhatti, Salman K.
   O'Keefe, James H.
   Lavie, Carl J.
TI Coffee and tea: perks for health and longevity?
SO CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE
LA English
DT Review
DE beverages; caffeine; coffee; LDL; HDL; tea
ID GREEN TEA; DECAFFEINATED COFFEE; METABOLIC SYNDROME; BLOOD-PRESSURE;
   CANCER-RISK; BLACK TEA; CONSUMPTION; CAFFEINE; METAANALYSIS; CATECHINS
AB Purpose of reviewTea and coffee, after water, are the most commonly consumed beverages in the world and are the top sources of caffeine and antioxidant polyphenols in the American diet. The purpose of this review is to assess the health effects of chronic tea and/or coffee consumption.Recent findingsTea consumption, especially green tea, is associated with significantly reduced risks for stroke, diabetes and depression, and improved levels of glucose, cholesterol, abdominal obesity and blood pressure. Habitual coffee consumption in large epidemiological studies is associated with reduced mortality, both for all-cause and cardiovascular deaths. In addition, coffee intake is associated with risks of heart failure, stroke, diabetes mellitus and some cancers in an inverse dose-dependent fashion. Surprisingly, coffee is associated with neutral to reduced risks for both atrial and ventricular arrhythmias. However, caffeine at high doses can increase anxiety, insomnia, calcium loss and possibly the risk of fractures.SummaryCoffee and tea can generally be recommended as health-promoting additions to an adult diet. Adequate dietary calcium intake may be particularly important for tea and coffee drinkers.
C1 [Bhatti, Salman K.; O'Keefe, James H.] St Lukes Mid Amer Heart Inst, Kansas City, MO 64111 USA.
   [Bhatti, Salman K.; O'Keefe, James H.] Univ Missouri, Kansas City, MO 64110 USA.
   [Lavie, Carl J.] Univ Queensland, Sch Med, Ochsner Clin Sch, John Ochsner Heart & Vasc Inst, New Orleans, LA USA.
   [Lavie, Carl J.] Louisiana State Univ Syst, Pennington Biomed Res Ctr, Dept Prevent Med, Baton Rouge, LA USA.
C3 Saint Luke's Mid America Heart Institute; University of Missouri System;
   University of Missouri Kansas City; Ochsner Health System; University of
   Queensland; Louisiana State University System; Louisiana State
   University; Pennington Biomedical Research Center
RP Bhatti, SK (corresponding author), St Lukes Mid Amer Heart Inst, 4330 Wornall Rd,Ste 2000, Kansas City, MO 64111 USA.
EM jokeefe@saint-lukes.org
RI Lavie, Carl/A-6014-2011
OI O'Keefe, James/0000-0002-3376-5822
CR [Anonymous], 2012, NAT COFF DRINK TREND
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NR 52
TC 45
Z9 52
U1 1
U2 138
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1363-1950
EI 1473-6519
J9 CURR OPIN CLIN NUTR
JI Curr. Opin. Clin. Nutr. Metab. Care
PD NOV
PY 2013
VL 16
IS 6
BP 688
EP 697
DI 10.1097/MCO.0b013e328365b9a0
PG 10
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 247BA
UT WOS:000326586800013
PM 24071782
DA 2025-06-11
ER

PT J
AU Chmielarz, M
   Sobieszczanska, B
   Teisseyre, A
   Wawrzynska, M
   Bozemska, E
   Sroda-Pomianek, K
AF Chmielarz, Mateusz
   Sobieszczanska, Beata
   Teisseyre, Andrzej
   Wawrzynska, Magdalena
   Bozemska, Edyta
   Sroda-Pomianek, Kamila
TI Palmitic Acid Modulates Microglial Cell Response to Metabolic
   Endotoxemia in an In Vitro Study
SO NUTRIENTS
LA English
DT Article
DE metabolic endotoxemia; microglial cells; palmitic acid; oxidative
   stress; inflammation
ID OBESITY; DIET; COGNITION; GLUTAMATE; MIDLIFE
AB Metabolic endotoxemia (ME) is characterized by a 2-3-fold increase in blood endotoxin levels and low-grade systemic inflammation without apparent infection. ME is usually accompanied by metabolic syndrome, characterized by central obesity and hyperlipidemia. According to numerous studies, ME may lead to functional brain disorders, including cognitive decline, depression, and dementia. In the current in vitro study, we aimed to determine the direct and indirect impact of endotoxin (LPS) and palmitic acid (PA), representing saturated fatty acids, on the inflammatory and oxidative stress response in the human microglial HMC3 cells unstimulated and stimulated with IFN & gamma;. The study's results revealed that direct HMC3 cell exposition to endotoxin and PA increased inflammatory response measured as levels of IL-6 and MCP-1 released into the medium and PGE2 levels in cell lysates. Moreover, direct HMC3 cell treatment with PA and LPS induced oxidative stress, i.e., ROS and COX-2 production and lipid peroxidation. On the contrary, an indirect effect of LPS and PA on microglial cells, assessed as the impact of macrophage metabolites, was much lower regarding the inflammatory response, although still associated with oxidative stress. Interestingly, IFN & gamma; had a protective effect on microglial cells, reducing the production of pro-inflammatory mediators and oxidative stress in HMC3 cells treated directly and indirectly with LPS and PA.
C1 [Chmielarz, Mateusz; Sobieszczanska, Beata; Bozemska, Edyta] Wroclaw Med Univ, Dept Microbiol, PL-50365 Wroclaw, Poland.
   [Teisseyre, Andrzej; Sroda-Pomianek, Kamila] Wroclaw Med Univ, Dept Biophys & Neurosci, PL-50365 Wroclaw, Poland.
   [Wawrzynska, Magdalena] Wroclaw Med Univ, Fac Hlth Sci, Dept Preclin Studies, PL-50365 Wroclaw, Poland.
C3 Wroclaw Medical University; Wroclaw Medical University; Wroclaw Medical
   University
RP Sobieszczanska, B (corresponding author), Wroclaw Med Univ, Dept Microbiol, PL-50365 Wroclaw, Poland.
EM mateusz.chmielarz@student.umw.edu.pl; beata.sobieszczanska@umw.edu.pl;
   andrzej.teisseyre@umw.edu.pl; magdalena.wawrzynska@umw.edu.pl;
   edyta.bozemska@umw.edu.pl; kamila.sroda-pomianek@umw.edu.pl
RI Chmielarz, Mateusz/NBX-1970-2025
OI Teisseyre, Andrzej/0000-0003-4802-8275; Chmielarz,
   Mateusz/0000-0002-5364-6556; Wawrzynska, Magdalena/0000-0001-6855-5510;
   Sroda-Pomianek, Kamila/0000-0003-3454-5044; Sobieszczanska,
   Beata/0000-0002-3355-2480
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NR 71
TC 1
Z9 1
U1 1
U2 4
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD AUG
PY 2023
VL 15
IS 15
AR 3463
DI 10.3390/nu15153463
PG 14
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA O7MJ0
UT WOS:001045603900001
PM 37571401
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Li, YR
   Zhao, LY
   Yu, DM
   Ding, GQ
AF Li, Yaru
   Zhao, Liyun
   Yu, Dongmei
   Ding, Gangqiang
TI Associations between serum uric acid and depression among middle-aged
   and elderly participants in China
SO PSYCHOLOGY HEALTH & MEDICINE
LA English
DT Article
DE Serum uric acid; depression; Chinese participants
ID METABOLIC SYNDROME; NATIONAL-HEALTH; SHORT-FORM; DISEASE; SYMPTOMS;
   PREVALENCE; COHORT; SCALE; RISK; SEX
AB Few studies have investigated the sex-related associations between serum uric acid and depression. This study aimed to explore the associations between serum uric acid and depression stratified by sex among middle-aged and elderly Chinese participants. Using the baseline data of the China health and retirement longitudinal study (CHARLS), a total of 10,522 participants aged 45 years and older were included in the final analysis. Depression symptoms were measured with the 10-term Center for Epidemiologic Studies Depression Scale (CES-D). A multivariable logistic regression model was performed to examine the associations between serum uric acid levels and depression, and the results are presented using odds ratios (ORs) and 95% confidence intervals (CIs). The prevalence of depression was 38% among middle-aged and elderly participants in China. In men, participants in the highest serum uric acid quartile had a decreased prevalence of depression relative to those in the lowest quartile (OR: 0.57; 95% CI: 0.41-0.81) after adjustment for potential confounders. However, there was no significant association between serum uric acid and depression among women. Participants with hyperuricemia were had no higher prevalence of depression relative to participants with normal serum uric acid level. Negative association between uric acid and depression was found in men, but not in women.
C1 [Li, Yaru; Zhao, Liyun; Yu, Dongmei; Ding, Gangqiang] Chinese Ctr Dis Control & Prevent, Natl Inst Nutr & Hlth, 27 Nanwei Rd, Beijing 100050, Peoples R China.
C3 Chinese Center for Disease Control & Prevention
RP Ding, GQ (corresponding author), Chinese Ctr Dis Control & Prevent, Natl Inst Nutr & Hlth, 27 Nanwei Rd, Beijing 100050, Peoples R China.
EM gangqiangding@163.com
RI ding, gangqiang/AHD-5012-2022
FU National Key Research and Development Program of China [2016YFD0400602]
FX This study was supported by the National Key Research and Development
   Program of China (2016YFD0400602).
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NR 26
TC 19
Z9 19
U1 2
U2 23
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 1354-8506
EI 1465-3966
J9 PSYCHOL HEALTH MED
JI Psychol. Health Med.
PD NOV 26
PY 2019
VL 24
IS 10
BP 1277
EP 1286
DI 10.1080/13548506.2019.1622748
EA MAY 2019
PG 10
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA JA3SP
UT WOS:000469696600001
PM 31131632
DA 2025-06-11
ER

PT J
AU Ownby, RL
AF Ownby, Raymond L.
TI Neuroinflammation and Cognitive Aging
SO CURRENT PSYCHIATRY REPORTS
LA English
DT Article
DE Cognition; Neuroinflammation; Cognitive aging; Cognition disorders;
   TNF-alpha
ID C-REACTIVE PROTEIN; METABOLIC SYNDROME; ALZHEIMER-DISEASE; DEPRESSIVE
   SYMPTOMS; FISH CONSUMPTION; OLDER PERSONS; RISK-FACTORS; FRAILTY;
   MEMORY; BRAIN
AB Cognitive aging describes the changes in mental abilities that occur with increasing age. Although experts disagree on the core underlying processes involved, one factor that links many factors associated with cognitive aging is neuroinflammation. Markers of inflammation are associated directly with deficits in cognitive function and with diseases that are risk factors for cognitive decline. Neuroinflammation is also associated with depression and may account for the complex interaction of depression and cognition in older adults. Interventions that reduce inflammation may improve cognition. Understanding how neuroinflammation affects cognition may provide directions for useful interventions to prevent or treat cognitive decline in older adults.
C1 Nova SE Univ, Ft Lauderdale, FL 33314 USA.
C3 Nova Southeastern University
RP Ownby, RL (corresponding author), Nova SE Univ, 3200 S Univ Dr,Room 1477, Ft Lauderdale, FL 33314 USA.
EM ro71@nova.edu
RI Ownby, Raymond/ABF-9335-2020
OI Ownby, Raymond/0000-0001-9433-2820
FU Janssen
FX Dr. Ownby has served on advisory boards and speaker panels for Forest
   Pharmaceuticals, Janssen, and Pfizer and has received grant support from
   Janssen.
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NR 63
TC 165
Z9 189
U1 0
U2 34
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1523-3812
EI 1535-1645
J9 CURR PSYCHIAT REP
JI Curr. Psychiatry Rep.
PD FEB
PY 2010
VL 12
IS 1
BP 39
EP 45
DI 10.1007/s11920-009-0082-1
PG 7
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 752YG
UT WOS:000289730800008
PM 20425309
DA 2025-06-11
ER

PT J
AU Eva, C
   Oberto, A
   Longo, A
   Palanza, P
   Bertocchi, I
AF Eva, Carola
   Oberto, Alessandra
   Longo, Angela
   Palanza, Paola
   Bertocchi, Ilaria
TI Sex differences in behavioral and metabolic effects of gene
   inactivation: The neuropeptide Y and Y receptors in the brain
SO NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
LA English
DT Review
DE Sex differences; Neuropeptide Y; Y receptors; Transgenic animal;
   Knockout animal; Energy homeostasis; Cognitive and emotional behavior
ID DEPRESSION-RELATED BEHAVIOR; AGOUTI-RELATED PROTEIN; INDUCED BONE LOSS;
   MICE LACKING; ENERGY HOMEOSTASIS; FEEDING-BEHAVIOR; DEPENDENT
   REGULATION; ARCUATE NUCLEUS; REDUCED ANXIETY; KNOCKOUT MICE
AB Brain and gonadal hormones interplay controls metabolic and behavioral functions in a sex-related manner. However, most translational neuroscience research related to animal models of endocrine and psychiatric disorders are often carried out in male animals only.
   The Neuropeptide Y (NPY) system shows sex-dependent differences and is sensitive to gonadal steroids. Based on published data from our and other laboratories, in this review we will discuss the sex related differences of NPY action on energy balance, bone homeostasis and behavior in rodents with the genetic manipulation of genes encoding NPY and its Y1, Y2 and Y5 cognate receptors.
   Comparative analyses of the phenotype of transgenic and knockout NPY and Y receptor rodents unravels sex dependent differences in the functions of this neurotransmission system, potentially helping to develop therapeutics for a variety of sex-related disorders including metabolic syndrome, osteoporosis and ethanol addiction.
C1 [Eva, Carola; Oberto, Alessandra; Longo, Angela; Bertocchi, Ilaria] Cavalieri Ottolenghi Fdn, Neurosci Inst, I-10043 Turin, Italy.
   [Eva, Carola; Oberto, Alessandra; Longo, Angela; Bertocchi, Ilaria] Univ Turin, Dept Neurosci, I-10126 Turin, Italy.
   [Eva, Carola; Oberto, Alessandra; Bertocchi, Ilaria] Univ Parma, Neurosci Inst Turin, I-43100 Parma, Italy.
   [Palanza, Paola] Univ Parma, Dept Med & Surg, I-43100 Parma, Italy.
C3 University of Turin; University of Parma; University of Parma
RP Eva, C (corresponding author), Univ Turin, Cavalieri Ottolenghi Fdn NICO, Neurosci Inst, Reg Gonzole 10, I-10043 Turin, Italy.
EM carola.eva@unito.it
RI Oberto, Alessandra/AAE-5205-2022; Bertocchi, Ilaria/AAE-5320-2022
OI Bertocchi, Ilaria/0000-0002-2880-716X; OBERTO,
   Alessandra/0000-0001-7799-4769
FU Cariplo Foundation [2013-0786]; Compagnia di San Paolo, Torino
   [S1315_RIC14_L2_EVC_01]; Fondazione CRT, Torino
FX This work was supported by Cariplo Foundation (grant 2013-0786),
   Compagnia di San Paolo, Torino (S1315_RIC14_L2_EVC_01) and Fondazione
   CRT, Torino to CE.
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NR 179
TC 16
Z9 19
U1 1
U2 15
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0149-7634
EI 1873-7528
J9 NEUROSCI BIOBEHAV R
JI Neurosci. Biobehav. Rev.
PD DEC
PY 2020
VL 119
BP 333
EP 347
DI 10.1016/j.neubiorev.2020.09.020
PG 15
WC Behavioral Sciences; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Behavioral Sciences; Neurosciences & Neurology
GA PH7FR
UT WOS:000600574200003
PM 33045245
DA 2025-06-11
ER

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   Roura-Poch, Pere
   Guimera-Gallent, Marta
   Santos-Lopez, Josep Manel
   Serra-Millas, Montserrat
   Frau-Rossello, Neus
   Gallego-Pena, Estefania
   Foguet-Boreu, Quinti
TI A Cardiovascular Risk Optimization Program in People With Schizophrenia:
   A Pilot Randomized Controlled Clinical Trial
SO JOURNAL OF PSYCHIATRIC PRACTICE
LA English
DT Article
DE schizophrenia; severe mental disorder; cardiovascular disease;
   cardiovascular risk; Framingham-REGICOR; cardiovascular risk factors;
   physical health; multifactorial intervention; patient-centered
   intervention
ID SERIOUS MENTAL-ILLNESS; METABOLIC SYNDROME; BIPOLAR DISORDER; PHYSICAL
   HEALTH; DISEASE RISK; MORTALITY; INTERVENTIONS; METAANALYSIS;
   ANTIPSYCHOTICS; CHOLESTEROL
AB Background:Cardiovascular disease is one of the leading causes of premature death in people with schizophrenia. Some modifiable factors that have been implicated include unhealthy lifestyle, medication side effects, and physical comorbidities. The goal of this study was to assess the efficacy of a 6-month, multifactorial cardiovascular risk intervention to reduce cardiovascular risk (CVR) in people with schizophrenia.Methods:We conducted a 2-arm, parallel, randomized clinical trial in a regional mental health center. Participants with at least 1 poorly controlled cardiovascular risk factor (CVRF) (hypertension, diabetes mellitus, hypercholesterolemia, or tobacco smoking) were randomly assigned to the intervention group or to a control group. The subjects in the intervention group received a patient-centered approach that included promoting a healthy lifestyle, pharmacological management of CVRFs, psychotropic drug optimization, and motivational follow-up [Programa d'optimitzacio del RISc CArdiovascular (PRISCA)]. The main outcome was change in CVR as assessed using the Framingham-REGICOR function, after 6 months compared with the baseline in both groups.Results:Forty-six participants were randomly assigned to the PRISCA group (n=23) or the control group (n=23). The most prevalent CVRFs at baseline were hypercholesterolemia (84.8%) and tobacco smoking (39.1%). The PRISCA group showed a significant reduction in the REGICOR score (-0.96%; 95% CI: -1.60 to -0.32, P=0.011) after 6 months (relative risk reduction of 20.9%), with no significant changes in the control group (0.21%; 95% CI: -0.47 to 0.89, P=0.706). In the PRISCA group, low-density lipoprotein cholesterol also decreased significantly (-27.14 mg/dL; 95% CI: -46.28 to -8.00, P=0.008).Conclusion:A patient-centered, multifactorial cardiovascular risk intervention improved CVR in people with schizophrenia after 6 months, which was achieved mainly by improving the lipid profile.
C1 [Riera-Molist, Nuria] Univ Vic, Vic Univ Hosp, Dept Pharm, Fac Med,Cent Univ Catalonia, Barcelona, Spain.
   [Riera-Molist, Nuria; Roura-Poch, Pere; Serra-Millas, Montserrat; Foguet-Boreu, Quinti] Inst Res & Innovat Life & Hlth Sci Cent Catalonia, Multidisciplinary Inflammat Res Grp MIRG, Barcelona, Spain.
   [Assens-Tauste, Montse] Vic Univ Hosp, Barcelona, Spain.
   [Roura-Poch, Pere] Univ Vic, Vic Univ Hosp, Cent Univ Catalonia, Fac Med,Dept Clin Epidemiol & Res, Vic, Spain.
   [Guimera-Gallent, Marta] Univ Vic, Cent Univ Catalonia, Occupat Risk Prevent, Barcelona, Spain.
   [Santos-Lopez, Josep Manel; Serra-Millas, Montserrat; Foguet-Boreu, Quinti] Univ Vic, Vic Univ Hosp, Cent Univ Catalonia, Fac Med,Dept Psychiat, Barcelona, Spain.
   [Santos-Lopez, Josep Manel] Univ Vic, Cent Univ Catalonia, Innovat Mental Hlth & Social Welf ISaMBeS, Barcelona, Spain.
   [Frau-Rossello, Neus; Gallego-Pena, Estefania] Catalan Hlth Inst, Primary Care Ctr Santa Eugenia de Berga, Barcelona, Spain.
   [Riera-Molist, Nuria] Consorci Hosp Vic, 1 Francesc Pla El Vigata, Barcelona 08500, Spain.
C3 University of Barcelona; Universitat de Vic - Universitat Central de
   Catalunya (UVic-UCC); Universitat de Vic - Universitat Central de
   Catalunya (UVic-UCC); Universitat de Vic - Universitat Central de
   Catalunya (UVic-UCC); Universitat de Vic - Universitat Central de
   Catalunya (UVic-UCC); University of Barcelona; Universitat de Vic -
   Universitat Central de Catalunya (UVic-UCC)
RP Riera-Molist, N (corresponding author), Consorci Hosp Vic, 1 Francesc Pla El Vigata, Barcelona 08500, Spain.
EM nriera@chv.cat; massens@chv.cat; proura@chv.cat;
   guimeramarta7@gmail.com; jmsantos@chv.cat; mserram@chv.cat;
   neusfrau@gmail.com; tefigallego@gmail.com; 42292qfb@comb.cat
RI Roura-Poch, Pere/F-2464-2011; Riera-Molist, Núria/HNR-6616-2023; Santos,
   Josep M/AAM-8268-2020
OI Santos, Josep M/0000-0002-2455-0408; Riera-Molist,
   Nuria/0000-0002-5530-0524
FU Academia de Ciencies Mediques i de la Salut de Catalunya i de Balears;
   XXII Beca Consultori Bayes en Ciencies de la Salut
FX This trial project was awarded the XX Osona Research Grant by the
   Academia de Ciencies Mediques i de la Salut de Catalunya i de Balears,
   September 2019. N.R.M. was awarded the XXII Beca Consultori Bayes en
   Ciencies de la Salut for her Doctoral Thesis project, of the Medicine
   and Biomedical Sciences Program, University of Vic- Central University
   of Catalonia, 08500 Vic, Barce-lona, Spain, November 2021. N.R.M. and
   Q.F.B. conducted the review of the available scientific literature and
   the study design. N.R.M., M.A.T., M.G.G., N.F.R., and E.G.P. integrated
   the multidisciplinary group and derived activities. N.R.M. coordinated
   the study. M.A.T. and N.R.M. conducted the face-to-face visits. P.R.P.,
   Q. F.B., and N.R.M. performed the statistical analysis of the data and
   its interpretation. Q.F.B., M.S.M., and J.M.S.L. acted as principal
   consultants and provided supervision. N.R.M. and Q.F.B. drafted the
   manuscript. All authors reviewed and provided modifications of the
   draft. All authors reviewed the final draft of the manuscript.
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NR 51
TC 0
Z9 0
U1 0
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1527-4160
EI 1538-1145
J9 J PSYCHIATR PRACT
JI J. Psychiatr. Pract.
PD NOV
PY 2023
VL 29
IS 6
BP 456
EP 468
DI 10.1097/PRA.0000000000000743
PG 13
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychiatry
GA Y2CD3
UT WOS:001103389600004
PM 37948170
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Bolton, JL
   Bilbo, SD
AF Bolton, Jessica L.
   Bilbo, Staci D.
TI Developmental programming of brain and behavior by perinatal diet: focus
   on inflammatory mechanisms
SO DIALOGUES IN CLINICAL NEUROSCIENCE
LA English
DT Article
DE anxiety; cognition; epigenetics; maternal high-fat diet; maternal
   obesity; microglia; neuroinflammation; perinatal programming; placenta
ID HIGH-FAT DIET; LONG-TERM CONSEQUENCES; EARLY-LIFE; MATERNAL OBESITY;
   GENE-EXPRESSION; IMMUNE-SYSTEM; METABOLIC SYNDROME; CYTOKINE EXPRESSION;
   DIABETES-MELLITUS; BIRTH-WEIGHT
AB Obesity is now epidemic worldwide. Beyond associated diseases such as diabetes, obesity is linked to neuropsychiatric disorders such as depression. Alarmingly, maternal obesity and high-fat diet consumption during gestation/lactation may "program" offspring long-term for increased obesity themselves, along with increased vulnerability to mood disorders. We review the evidence that programming of brain and behavior by perinatal diet is propagated by inflammatory mechanisms, as obesity and high-fat diets are independently associated with exaggerated systemic levels of inflammatory mediators. Due to the recognized dual role of these immune molecules (eg, interleukin [IL]-6, IL-1 beta) in placental function and brain development, any disruption of their delicate balance with growth factors or neurotransmitters ( eg, serotonin) by inflammation early in life can permanently alter the trajectory of fetal brain development. Finally, epigenetic regulation of inflammatory pathways is a likely candidate for persistent changes in metabolic and brain function as a consequence of the perinatal environment. (C) 2014, AICH - Servier Research Group
C1 [Bolton, Jessica L.; Bilbo, Staci D.] Duke Univ, Dept Psychol & Neurosci, Duke Inst Brain Sci, Durham, NC USA.
C3 Duke University
RP Bilbo, SD (corresponding author), Duke Univ, Dept Psychol & Neurosci, 210 Res Dr,3016 GSRB 2, Durham, NC 27710 USA.
EM staci.bilbo@duke.edu
RI ; Bilbo, Staci/L-5076-2016; Bolton, Jessica/AAE-8243-2020
OI Bilbo, Staci/0000-0001-7395-5033; Bilbo, Staci/0000-0001-6736-7841;
   Bolton, Jessica/0000-0002-8872-4999
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NR 155
TC 113
Z9 129
U1 0
U2 16
PU INST CONFERENCE HIPPOCRATE
PI SURESNESS-CEDEX
PA 50 RUE CARNOT, SURESNESS-CEDEX, 92284, FRANCE
SN 1294-8322
EI 1958-5969
J9 DIALOGUES CLIN NEURO
JI Dialogues Clin. Neurosci.
PD SEP
PY 2014
VL 16
IS 3
BP 307
EP 320
PG 14
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA V45QR
UT WOS:000209831600004
PM 25364282
DA 2025-06-11
ER

PT J
AU Fond, G
   Fajula, C
   Dassa, D
   Brunel, L
   Lancon, C
   Boyer, L
AF Fond, Guillaume
   Fajula, Claire
   Dassa, Daniel
   Brunel, Lore
   Lancon, Christophe
   Boyer, Laurent
TI Potentially inappropriate psychotropic prescription at discharge is
   associated with lower functioning in the elderly psychiatric inpatients.
   A cross-sectional study
SO PSYCHOPHARMACOLOGY
LA English
DT Article
DE Potentially inappropriate psychotropic prescription; Elderly;
   Benzodiazepines; Psychiatric disorder; Inpatient; Functioning
ID MEDICATION USE; OLDER-PEOPLE; BENZODIAZEPINE USE; CLINICAL
   EFFECTIVENESS; METABOLIC SYNDROME; CONSENSUS PANEL; BEERS CRITERIA;
   INTERVENTIONS; METAANALYSIS; ANXIETY
AB Objective The objectives are to determine the rate of potentially inappropriate psychotropic (PIP) prescription at discharge in the elderly psychiatric inpatients and to determine whether PIP is associated with lowered functioning outcomes.
   Methods Sociodemographic, clinical, and treatment data for all inpatients aged >= 65 years consecutively hospitalized during 1 year in 13 psychiatry departments was analyzed. PIP+/PIP- groups were defined according to the French-updated Beers criteria. Daily functioning was evaluated by the daily living (ADL) scale. Logistic regression analysis was used to estimate odds ratios for the association between PIP administration at discharge and respectively functioning and potential confounding factors.
   Results Data was obtained for 327 patients. Overall, 124 (37.9 %) patients were males, and the mean age was 73.9 years (SD=5.6); 163 (49.8%) patients were diagnosed with affective disorders and 89 (27.2%) with schizophrenia/schizotypal/delusional disorders. Overall, 249 (76.1 %) had one or more PIP medications, mainly anxiolytics (69.9 %) and hypnotics (17.2 %). In a multivariate analysis, PIP prescription at discharge has been associated with patient lowered personal care functioning, independently of age, gender, and psychiatric or somatic diagnoses (OR=0.88 (0.79-0.97, p=0.01).
   Conclusion In the current increasingly fragmented health care systems, special attention must be given to PIP prescription in older population suffering from psychiatric disorders. Using the Beers criteria, the present study demonstrates the high prevalence of PIP prescription, which concerns a large panel of drugs but mostly anxiolytics and hypnotics independently of psychiatric or somatic diagnoses and sociodemographic characteristics. Our study has demonstrated for the first time an association between PIP prescription and lowered patient functioning. Further longitudinal studies should confirm a potential causal relation.
C1 [Fond, Guillaume; Brunel, Lore; Lancon, Christophe] Fdn FondaMental, Creteil, France.
   [Fond, Guillaume] INSERM, U955, Translat Psychiat Team, Creteil, France.
   [Fond, Guillaume] Paris Est Univ, DHU Pe PSY, Hop Univ H Mondor, Pole Psychiat, Creteil, France.
   [Fond, Guillaume; Brunel, Lore] Hop A Chenevier, Pole Psychiat, 40 Rue Mesly, F-94010 Creteil, France.
   [Fajula, Claire] St Marguerite Univ Hosp, Assistance Publ Hop Marseille, Dept Psychiat, F-13009 Marseille, France.
   [Dassa, Daniel] La Conception Univ Hosp, Assistance Publ Hop Marseille, Dept Psychiat, F-13005 Marseille, France.
   [Lancon, Christophe; Boyer, Laurent] Univ Hosp, Assistance Publ Hop Marseille, Dept Publ Hlth, EA 3279,Res Unit, F-13005 Marseille, France.
C3 Institut National de la Sante et de la Recherche Medicale (Inserm);
   Universite Paris-Est-Creteil-Val-de-Marne (UPEC); Assistance Publique
   Hopitaux Paris (APHP); Universite Paris-Est-Creteil-Val-de-Marne (UPEC);
   Hopital Universitaire Henri-Mondor - APHP; Universite
   Paris-Est-Creteil-Val-de-Marne (UPEC); Assistance Publique Hopitaux
   Paris (APHP); Hopital Universitaire Henri-Mondor - APHP; Aix-Marseille
   Universite; Assistance Publique-Hopitaux de Marseille; Aix-Marseille
   Universite; Assistance Publique-Hopitaux de Marseille; Aix-Marseille
   Universite; Assistance Publique-Hopitaux de Marseille
RP Fond, G (corresponding author), Fdn FondaMental, Creteil, France.; Fond, G (corresponding author), INSERM, U955, Translat Psychiat Team, Creteil, France.; Fond, G (corresponding author), Paris Est Univ, DHU Pe PSY, Hop Univ H Mondor, Pole Psychiat, Creteil, France.; Fond, G (corresponding author), Hop A Chenevier, Pole Psychiat, 40 Rue Mesly, F-94010 Creteil, France.
EM guillaume.fond@gmail.com
RI FOND, Guillaume/D-7646-2011; Boyer, Laurent/E-5728-2016
OI FOND, Guillaume/0000-0003-3249-2030; Boyer, Laurent/0000-0003-1229-6622
FU AP-HM (Assistance Publique des Hopitaux de Marseille); AP-HP (Assistance
   Publique des Hopitaux de Paris); Fondation FondaMental (RTRS Sante
   Mentale); INSERM (Institut National de la Sante et de la Recherche
   Medicale)
FX This work was supported by AP-HM (Assistance Publique des Hopitaux de
   Marseille) and AP-HP (Assistance Publique des Hopitaux de Paris),
   Fondation FondaMental (RTRS Sante Mentale), and by INSERM (Institut
   National de la Sante et de la Recherche Medicale). We express all our
   thanks to the nurses and to the patients who were included in the
   present study.
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NR 48
TC 15
Z9 15
U1 1
U2 7
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0033-3158
EI 1432-2072
J9 PSYCHOPHARMACOLOGY
JI Psychopharmacology
PD JUL
PY 2016
VL 233
IS 13
BP 2549
EP 2558
DI 10.1007/s00213-016-4312-z
PG 10
WC Neurosciences; Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA DP5ZE
UT WOS:000378575900013
PM 27129863
DA 2025-06-11
ER

PT J
AU Jaishy, B
   Abel, ED
AF Jaishy, Bharat
   Abel, E. Dale
TI Thematic Review Series: Lipotoxicity: Many Roads to
   Cell Dysfunction and Cell Death Lipids, lysosomes, and autophagy
SO JOURNAL OF LIPID RESEARCH
LA English
DT Review
DE lipid metabolism; lipotoxicity; lysosomal dysfunction; lipophagy;
   oxidative stress; reactive oxygen species
ID HIGH-FAT DIET; CHAPERONE-MEDIATED AUTOPHAGY; RAT-LIVER LYSOSOMES;
   ENDOPLASMIC-RETICULUM STRESS; PANCREATIC BETA-CELLS; VACUOLAR H+-ATPASE;
   INSULIN-RESISTANCE; SKELETAL-MUSCLE; OXIDATIVE STRESS; METABOLIC
   SYNDROME
AB Lipids are essential components of a cell providing energy substrates for cellular processes, signaling intermediates, and building blocks for biological membranes. Lipids are constantly recycled and redistributed within a cell. Lysosomes play an important role in this recycling process that involves the recruitment of lipids to lysosomes via autophagy or endocytosis for their degradation by lysosomal hydrolases. The catabolites produced are redistributed to various cellular compartments to support basic cellular function. Several studies demonstrated a bidirectional relationship between lipids and lysosomes that regulate autophagy. While lysosomal degradation pathways regulate cellular lipid metabolism, lipids also regulate lysosome function and autophagy. In this review, we focus on this bidirectional relationship in the context of dietary lipids and provide an overview of recent evidence of how lipid-overload lipotoxicity, as observed in obesity and metabolic syndrome, impairs lysosomal function and autophagy that may eventually lead to cellular dysfunction or cell death.
C1 [Abel, E. Dale] Univ Iowa, Roy J & Lucille A Carver Coll Med, Fraternal Order Eagles Diabet Res Ctr, Iowa City, IA 52242 USA.
   Univ Iowa, Roy J & Lucille A Carver Coll Med, Div Endocrinol & Metab, Iowa City, IA 52242 USA.
   [Jaishy, Bharat] Uni Texas Southwestern Med Ctr, Dept Mol Genet, Dallas, TX 75390 USA.
C3 University of Iowa; University of Iowa; University of Texas System;
   University of Texas Southwestern Medical Center Dallas
RP Abel, ED (corresponding author), Univ Iowa, Roy J & Lucille A Carver Coll Med, Fraternal Order Eagles Diabet Res Ctr, Iowa City, IA 52242 USA.
EM DRCadmin@uiowa.edu
RI Jaishy, Bharat/E-4705-2015
OI Jaishy, Bharat/0000-0001-7619-7944; Abel, E. Dale/0000-0001-5290-0738
FU Office of Extramural Research, National Institutes of Health
   [R01HL108379]
FX This work was supported by Office of Extramural Research, National
   Institutes of Health Grant R01HL108379. The content is solely the
   responsibility of the authors and does not necessarily represent the
   official views of the National Institutes of Health.
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NR 156
TC 169
Z9 187
U1 0
U2 38
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0022-2275
EI 1539-7262
J9 J LIPID RES
JI J. Lipid Res.
PD SEP
PY 2016
VL 57
IS 9
BP 1619
EP 1635
DI 10.1194/jlr.R067520
PG 17
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA DW1VR
UT WOS:000383431700004
PM 27330054
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Lippi, G
   Montagnana, M
   Franchini, M
   Favaloro, EJ
   Targher, G
AF Lippi, Giuseppe
   Montagnana, Martina
   Franchini, Massimo
   Favaloro, Emmanuel J.
   Targher, Giovanni
TI The paradoxical relationship between serum uric acid and cardiovascular
   disease
SO CLINICA CHIMICA ACTA
LA English
DT Review
DE cardiovascular disease; chronic heart failure; oxidation; risk; uric
   acid
ID CHRONIC HEART-FAILURE; ORGANIC ANION TRANSPORTER; XANTHINE-OXIDASE
   INHIBITION; ALL-CAUSE MORTALITY; METABOLIC SYNDROME; OXIDATIVE STRESS;
   ENDOTHELIAL DYSFUNCTION; INSULIN-RESISTANCE; MOLECULAR-CLONING;
   BLOOD-PRESSURE
AB Uric acid (urate), an organic compound comprised of carbon, nitrogen, oxygen and hydrogen, is the final oxidation product of purine catabolism in humans, higher primates and in a particular species of dog (Dalmatians). For decades it has been hypothesized that the antioxidant properties of uric acid might be protective against aging, oxidative stress, and oxidative cell injury. However, recent epidemiological and clinical evidences suggest that hyperuricaemia might be a risk factor for cardiovascular disease, where enhanced oxidative stress plays an important pathophysiological role. It has also been hypothesized that that hyperuricaemia might be involved in chronic heart failure and metabolic syndrome. The apparent paradox between protective and toxic effects is supported by clinical evidences that antioxidant compounds may become pro-oxidant compounds in certain situations, particularly when they are present in blood at supranormal levels. The aim of this article is to review uric acid metabolism and physiology, highlighting its association with cardiovascular disease. (c) 2008 Elsevier B.V. All rights reserved.
C1 [Lippi, Giuseppe; Montagnana, Martina] Univ Verona, Sez Chim Clin, Dipartimento Sci Biomed & Morfol, I-37100 Verona, Italy.
   [Franchini, Massimo] Azienda Osped Verona, Ctr Emofilia, Serv Immunoematol & Transfus, Verona, Italy.
   [Favaloro, Emmanuel J.] Westmead Hosp, ICPMR, Dept Haematol, Westmead, NSW 2145, Australia.
   [Targher, Giovanni] Univ Verona, Sez Endocrinol, Dipartimento Sci Biomed & Chirurg, I-37100 Verona, Italy.
C3 University of Verona; University of Verona; Azienda Ospedaliera
   Universitaria Integrata Verona; University of Sydney; NSW Health;
   Westmead Hospital; University of Verona
RP Lippi, G (corresponding author), Osped Policlin GB Rossi, Sez Chim Clin, Dipartimento Sci Morfol Biomed, Piazzale Scuro 10, I-37134 Verona, Italy.
EM giuseppe.lippi@univr.it
RI Targher, Giovanni/AAB-9008-2019; Franchini, Massimo/AAB-7345-2022;
   Lippi, Giuseppe/X-7198-2018; Favaloro, Emmanuel/J-7689-2019
OI Favaloro, Emmanuel J/0000-0002-2103-1661
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NR 139
TC 195
Z9 229
U1 1
U2 16
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0009-8981
EI 1873-3492
J9 CLIN CHIM ACTA
JI Clin. Chim. Acta
PD JUN
PY 2008
VL 392
IS 1-2
BP 1
EP 7
DI 10.1016/j.cca.2008.02.024
PG 7
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA 311DQ
UT WOS:000256581000001
PM 18348869
DA 2025-06-11
ER

PT J
AU Voicehovska, J
   Vlaskovska, M
   Janovska, J
   Babikovs, S
   Voicehovskis, V
   Skesters, A
   Silova, A
   Karpovs, J
   Zubova, O
   Kisis, J
   Daberte, I
   Spruda, D
   Kleina, R
AF Voicehovska, Julija
   Vlaskovska, Mila
   Janovska, Jana
   Babikovs, Sergejs
   Voicehovskis, Vladimirs
   Skesters, Andrejs
   Silova, Alise
   Karpovs, Jurijs
   Zubova, Olga
   Kisis, Janis
   Daberte, Irena
   Spruda, Dagmara
   Kleina, Regina
TI OXIDATIVE STRESS MARKERS DIAGNOSTIC VALUE IN METABOLIC SYNDROME DERMAL
   MANIFESTATIONS: A PROSPECTIVE CLINICAL TRIAL
SO COMPTES RENDUS DE L ACADEMIE BULGARE DES SCIENCES
LA English
DT Article
DE biomarkers; oxidative stress; metabolism
ID SKIN; MECHANISMS; OBESE
AB Metabolic syndrome (MS) is a combination of hormonal, metabolic and clinical disorders developing on the background of central obesity. Supposedly, oxidative stress (OS) takes central part in MS pathogenesis. It is suggested, that latent inflammation that accompanies MS is based on excessive amounts of free radicals. Skin is under constant external factor influence which initiates free radical reactions with following lipid peroxidation, protein and DNA oxidative damage. Combining external and MS induced changes, skin manifestations may provide insight on dermal antioxidative capacity and OS. Aim of current study is to evaluate correlations of OS parameters and dermal MS manifestations.
   Current prospective clinical trial was conducted on 94 individuals, of them 57 with diagnosed MS and 37 almost healthy individuals. Anthropometric data, blood testing for MS and OS markers were assessed. We performed biopsy sampling of the skin for histologic evaluation in order to correlate serum OS marker levels with morphologic manifestations. MDA and SOD levels were higher in MS patients. Elevation of SOD positively correlated with all tested histologic signs of dermal degeneration, elastosis and sustained inflammation. OS biomarkers may be used in early MS identification in risk groups and for unfavourable course assessment.
C1 [Janovska, Jana; Babikovs, Sergejs; Voicehovskis, Vladimirs; Karpovs, Jurijs; Zubova, Olga] Riga Stradins Univ, Dept Internal Dis, 16 Dzirciema St, LV-1007 Riga, Latvia.
   [Vlaskovska, Mila] Med Univ Sofia, Fac Med, Dept Pharmacol & Toxicol, 1 Georgi Sofiiski St, Sofia 1143, Bulgaria.
   [Skesters, Andrejs; Silova, Alise] Riga Stradins Univ, Biochem Lab, 16 Dzirciema St, LV-1007 Riga, Latvia.
   [Kisis, Janis] Riga Stradins Univ, Dept Infectol & Dermatol, 16 Dzirciema St, LV-1007 Riga, Latvia.
   [Daberte, Irena] Riga Stradins Univ, Dept Dosage Form Technol, 16 Dzirciema St, LV-1007 Riga, Latvia.
   [Spruda, Dagmara] Riga Stradins Univ, Lab Hyg & Occupat Dis, 16 Dzirciema St, LV-1007 Riga, Latvia.
   [Kleina, Regina] Riga Stradins Univ, Dept Pathol, P Stradina Clin Univ Hosp, 13 Pilsonu St, LV-1002 Riga, Latvia.
C3 Riga Stradins University; Medical University Sofia; Riga Stradins
   University; Riga Stradins University; Riga Stradins University; Riga
   Stradins University; Pauls Stradins Clinical University Hospital; Riga
   Stradins University
RP Voicehovska, J (corresponding author), Riga Stradins Univ, Dept Internal Dis, 16 Dzirciema St, LV-1007 Riga, Latvia.
EM dr.julia.v@gmail.com; mvlaskovska7@gmail.com; j.a.janovska@gmail.com;
   sergejs.babikovs@gmail.com; voicheh@me.com; Andrejs.Skesters@rsu.lv;
   Alise.silova@rsu.lv; juriskarpovs1@inbox.lv; doczubova@gmail.com;
   profkisis@inbox.lv; Irena.Daberte@rsu.lv; dagmara.sprudza@rsu.lv;
   regina.kleina@rsu.lv
OI Kleina, Regina/0000-0003-1412-1631; Voicehovska, Julija
   Genri/0000-0002-4127-1654; Babikovs, Sergejs/0000-0001-9674-4298;
   Voicehovskis, Vladimirs/0000-0002-9237-395X
FU European Regional Development Fund (ERDF)
   [2014/0024/2DP/2.1.1.1.0/14/APIA/VIAA/076]
FX Research was funded partially by European Regional Development Fund
   (ERDF), No 2014/0024/2DP/2.1.1.1.0/14/APIA/VIAA/076.
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NR 19
TC 0
Z9 0
U1 0
U2 4
PU PUBL HOUSE BULGARIAN ACAD SCI
PI SOFIA
PA ACADEMICIAN G BONCEV ST, 1113 SOFIA, BULGARIA
SN 1310-1331
J9 CR ACAD BULG SCI
JI C. R. Acad. Bulg. Sci.
PY 2018
VL 71
IS 2
BP 271
EP 279
PG 11
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA GA4ZS
UT WOS:000428342500015
DA 2025-06-11
ER

PT J
AU Peyrol, J
   Riva, C
   Amiot, MJ
AF Peyrol, Julien
   Riva, Catherine
   Amiot, Marie Josephe
TI Hydroxytyrosol in the Prevention of the Metabolic Syndrome and Related
   Disorders
SO NUTRIENTS
LA English
DT Review
DE olive oil; oleuropein; hydroxytyrosol; tyrosol; body weight;
   dyslipidemia; hyperglycemia; hypertension; oxidative stress;
   inflammation
ID VIRGIN OLIVE OIL; LOW-DENSITY-LIPOPROTEIN; REDUCES OXIDATIVE STRESS;
   CORONARY-HEART-DISEASE; MILL WASTE-WATER; PHENOLIC-COMPOUNDS;
   MEDITERRANEAN DIET; LEAF EXTRACT; MITOCHONDRIAL DYSFUNCTION; ENDOTHELIAL
   DYSFUNCTION
AB Virgin olive oil (VOO) constitutes the main source of fat in the Mediterranean diet. VOO is rich in oleic acid, displaying health-promoting properties, but also contains minor bioactive components, especially phenolic compounds. Hydroxytyrosol (HT), the main polyphenol of olive oil, has been reported to be the most bioactive component. This review aims to compile the results of clinical, animal and cell culture studies evaluating the effects of HT on the features of Metabolic Syndrome (MetS) (body weight/adiposity, dyslipidemia, hypertension, and hyperglycemia/insulin resistance) and associated complications (oxidative stress and inflammation). HT was able to improve the lipid profile, glycaemia, and insulin sensitivity, and counteract oxidative and inflammatory processes. Experimental studies identified multiple molecular targets for HT conferring its beneficial effect on health in spite of its low bioavailability. However, rodent experiments and clinical trials with pure HT at biologically relevant concentrations are still lacking. Moreover, the roles of intestine and its gut microbiota have not been elucidated.
C1 [Peyrol, Julien; Riva, Catherine] Avignon Univ, Fac Sci, Dept Sport Sci, Lab Cardiovasc Pharm Ecol EA4278, F-84000 Avignon, France.
   [Amiot, Marie Josephe] Aix Marseille Univ, UMR, Nutr Obes & Risk Thrombosis, F-13005 Marseille, France.
   [Amiot, Marie Josephe] UMR, Markets Org Inst Stakeholder Strategies, F-34060 Montpellier, France.
   [Amiot, Marie Josephe] Ctr Cooperat Int Rech Agronom Dev, F-34060 Montpellier, France.
   [Amiot, Marie Josephe] Ctr Int Hautes Etud Agronom Mediterraneennes, F-34060 Montpellier, France.
   [Amiot, Marie Josephe] Montpellier SupAgro, F-34060 Montpellier, France.
   [Amiot, Marie Josephe] Inst Natl Rech Agronom, Div Nutr Chem Food Safety & Consumer Behav, F-75015 Paris, France.
   [Amiot, Marie Josephe] Inst Natl Sante & Rech Med, F-75015 Paris, France.
C3 Avignon Universite; Aix-Marseille Universite; CIRAD; CIHEAM; CIHEAM IAM
   Montpellier; Institut Agro; Montpellier SupAgro; INRAE; Institut
   National de la Sante et de la Recherche Medicale (Inserm)
RP Riva, C (corresponding author), Avignon Univ, Fac Sci, Dept Sport Sci, Lab Cardiovasc Pharm Ecol EA4278, F-84000 Avignon, France.; Amiot, MJ (corresponding author), Aix Marseille Univ, UMR, Nutr Obes & Risk Thrombosis, F-13005 Marseille, France.; Amiot, MJ (corresponding author), UMR, Markets Org Inst Stakeholder Strategies, F-34060 Montpellier, France.; Amiot, MJ (corresponding author), Ctr Cooperat Int Rech Agronom Dev, F-34060 Montpellier, France.; Amiot, MJ (corresponding author), Ctr Int Hautes Etud Agronom Mediterraneennes, F-34060 Montpellier, France.; Amiot, MJ (corresponding author), Montpellier SupAgro, F-34060 Montpellier, France.; Amiot, MJ (corresponding author), Inst Natl Rech Agronom, Div Nutr Chem Food Safety & Consumer Behav, F-75015 Paris, France.; Amiot, MJ (corresponding author), Inst Natl Sante & Rech Med, F-75015 Paris, France.
EM julien.peyrol@univ-avignon.fr; catherine.riva@univ-avignon.fr;
   marie-josephe.amiot.carlin@inra.fr
RI AMIOT, MARIE/N-8894-2019; AMIOT, Marie Josephe/M-1203-2017
OI AMIOT, Marie Josephe/0000-0003-4563-4587
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NR 143
TC 105
Z9 109
U1 2
U2 30
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD MAR
PY 2017
VL 9
IS 3
AR 306
DI 10.3390/nu9030306
PG 18
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA EO9QQ
UT WOS:000397023600125
PM 28335507
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Manchanda, SC
   Madan, K
AF Manchanda, S. C.
   Madan, Kushal
TI Yoga and meditation in cardiovascular disease
SO CLINICAL RESEARCH IN CARDIOLOGY
LA English
DT Review
DE Hatha yoga; Transcendental meditation; Hypertension; Metabolic syndrome;
   Dyslipidemia; Coronary heart disease
ID RANDOMIZED CONTROLLED-TRIAL; AMBULATORY BLOOD-PRESSURE;
   TRANSCENDENTAL-MEDITATION; STRESS REDUCTION; INSULIN-RESISTANCE;
   ANTIOXIDANT STATUS; METABOLIC SYNDROME; OXIDATIVE STRESS; HYPERTENSION;
   MANAGEMENT
AB Yoga is a holistic mind-body intervention aimed at physical, mental, emotional and spiritual well being. Several studies have shown that yoga and/or meditation can control risk factors for cardiovascular disease like hypertension, type II diabetes and insulin resistance, obesity, lipid profile, psychosocial stress and smoking. Some randomized studies suggest that yoga/meditation could retard or even regress early and advanced coronary atherosclerosis. A recent study suggests that transcendental meditation may be extremely useful in secondary prevention of coronary heart disease and may reduce cardiovascular events by 48 % over a 5-year period. Another small study suggests that yoga may be helpful in prevention of atrial fibrillation. However, most studies have several limitations like lack of adequate controls, small sample size, inconsistencies in baseline and different methodologies, etc. and therefore large trials with improved methodologies are required to confirm these findings. However, in view of the existing knowledge and yoga being a cost-effective technique without side effects, it appears appropriate to incorporate yoga/meditation for primary and secondary prevention of cardiovascular disease.
C1 [Manchanda, S. C.; Madan, Kushal] Sir Ganga Ram Hosp, Dharma Vira Heart Ctr, New Delhi 110060, India.
RP Manchanda, SC (corresponding author), Sir Ganga Ram Hosp, Dharma Vira Heart Ctr, New Delhi 110060, India.
EM doctormanchanda@yahoo.com
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NR 70
TC 33
Z9 38
U1 0
U2 103
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1861-0684
EI 1861-0692
J9 CLIN RES CARDIOL
JI Clin. Res. Cardiol.
PD SEP
PY 2014
VL 103
IS 9
BP 675
EP 680
DI 10.1007/s00392-014-0663-9
PG 6
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA AN4CL
UT WOS:000340535100001
PM 24464106
DA 2025-06-11
ER

PT J
AU Corona, G
   Rastrelli, G
   Sparano, C
   Vignozzi, L
   Maggi, M
AF Corona, Giovanni
   Rastrelli, Giulia
   Sparano, Clotilde
   Vignozzi, Linda
   Maggi, Mario
TI Acquired hypoprolactinemia in men, possible phenotype
SO REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
LA English
DT Review
DE Prolactine; Hypoprolactinemia; Diabetes mellitus; Metabolic sydrome;
   Erectile dysfunction; Sexual dysfunction
ID CENTRAL SEROTONERGIC RESPONSIVITY; SERUM PROLACTIN CONCENTRATIONS;
   CIRCULATING PROLACTIN; ERECTILE DYSFUNCTION; METABOLIC SYNDROME;
   CHALLENGE TEST; NEUROENDOCRINE; ASSOCIATION; SYMPTOMS; RECEPTOR
AB The physiological role of prolactin (PRL) in men is still not well defined. The pathological increase is characterized by sexual function impairment along with possible negative consequences in body composition and metabolic profile. Conversely, the clinical significance of reduced PRL levels was only partially investigated or mainly neglected. The present paper aims to summarize and critically discuss possible phenotypes characterizing male subjects with reduced PRL levels. When possible, meta-analytic results were provided. Available data derived from patients seeking medical care for sexual dysfunction as well as from cross-sectional and longitudinal studies showed that low PRL in males is associated with a worse metabolic phenotype (including diabetes mellitus), mood disturbances (including anxiety and depression), and sexual dysfunctions (including psychogenic erectile and ejaculatory dysfunctions). Whether or not these features are direct consequences of reduced PRL levels or whether the latter reflect other pathway impairments such as serotoninergic failure cannot be clarified. The present data, however, emphasize that a deficiency of PRL should be taken into account and need further investigations.
C1 [Corona, Giovanni] Azienda AUSL Bologna, Endocrinol Unit, Bologna, Italy.
   [Rastrelli, Giulia; Vignozzi, Linda] Univ Florence, Mario Serio Dept Expt & Clin Biomed Sci, Female Endocrinol & Gender Incongruence Unit, Florence, Italy.
   [Sparano, Clotilde; Maggi, Mario] Univ Florence, Mario Serio Dept Expt & Clin Biomed Sci, Endocrinol Unit, Viale Pieraccini 6, I-50139 Florence, Italy.
C3 AUSL di Bologna; University of Florence; University of Florence
RP Maggi, M (corresponding author), Univ Florence, Mario Serio Dept Expt & Clin Biomed Sci, Endocrinol Unit, Viale Pieraccini 6, I-50139 Florence, Italy.
EM mario.maggi@unifi.it
RI Maggi, Mario/AAB-8284-2019; Sparano, Clotilde/HCI-9304-2022
OI Sparano, Clotilde/0000-0002-3766-4682
FU Universit degli Studi di Firenze; Next Generation EU [DM 1557
   11.10.2022]; National Recovery and Resilience Plan - Next Generation EU
FX We acknowledge co-funding from Next Generation EU, in the context of the
   National Recovery and Resilience Plan, Investment PE8- Project Age-It:
   "Ageing Well in an Ageing Society". This resource was co-financed by the
   Next Generation EU [DM 1557 11.10.2022]. The views and opinions
   expressed are only those of the authors and do not necessarily reflect
   those of the European Union or the European Commission. Neither the
   European Union nor the European Commission can be held responsible for
   them.
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NR 77
TC 0
Z9 0
U1 1
U2 2
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1389-9155
EI 1573-2606
J9 REV ENDOCR METAB DIS
JI Rev. Endocr. Metab. Disord.
PD DEC
PY 2024
VL 25
IS 6
SI SI
BP 1109
EP 1119
DI 10.1007/s11154-024-09895-9
EA JUL 2024
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA O4Z6Y
UT WOS:001277857300001
PM 39066947
OA hybrid
DA 2025-06-11
ER

PT J
AU Asare, GA
   Sule, DS
   Oblitey, JN
   Ntiforo, R
   Asiedu, B
   Amoah, BY
   Lamptey, EL
   Afriyie, DK
   Botwe, BO
AF Asare, George A.
   Sule, Derick S.
   Oblitey, Jared N.
   Ntiforo, Reese
   Asiedu, Bernice
   Amoah, Brodrick Y.
   Lamptey, Emmanuel L.
   Afriyie, Daniel K.
   Botwe, Benard Ohene
TI High degree of prostate related LUTS in a prospective cross-sectional
   community study in Ghana (Mamprobi)
SO HELIYON
LA English
DT Article
DE Lower urinary tract symptoms (LUTS); Benign prostatic hyperplasia (BPH);
   Prostate volume; Metabolic syndrome (MetS)
ID URINARY-TRACT SYMPTOMS; METABOLIC SYNDROME; HYPERPLASIA BPH; MEN;
   ASSOCIATION; PREVALENCE; RISK; ENLARGEMENT; PROGRESSION; STORAGE
AB Background: Changing voiding patterns, volume and frequency, may sometimes be mistaken for anxiety, stress or increase in fluid consumption. In the aging male population, the commencement of lower urinary tract symptoms (LUTS) may be silent and perceived as "normal" and unrelated to Benign prostatic enlargement (BPE). The purpose of the study was to determine the prevalence of apparently "silent LUTS" (perceived asymptomatic LUTS) in men in a Ghanaian Community as well as its underlying risk factors. Methods: One hundred and eleven (111) men (40-70 years) were recruited from a community in Ghana. The International Prostate Symptoms Score (IPSS) questionnaire (administered in the local language and English) and ultrasonographic imaging of the prostate volume (PV) were utlized to collect data. IPSS score >7 plus PV > 30 cm3 was definitive of lower urinary tract symptoms. Eighty-one (81) participants were classified "LUTS Negative" (LN) and 30, "LUTS Positive" (LP). Risk factors i.e., cholesterol (CHOL), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), very low-density lipoprotein (VLDL), coronary risk (CR), BMI and Blood Pressure were also determined. Results: The prevalence of LUTS using only IPSS definition alone was 42.3%. However, IPSS in combination with Prostate Volume gave a prevalence of 27.0%. LN subjects had enlarged prostate (41.98%) and LP, 100%. Quality of life (QoL) was better in the LUTS Negative than LUTS Positive group (p < 0.001). In the univariant analysis coronary risk, triglyceride and VLDL contributed to LUTS (p = 0.023, 0.22, 0.22, respectively). In a multivariant analysis HDL-C (p = 0.027), BMI (p = 0.047) and triglyceride (p = 0.019) significantly contributed to LUTS. Conclusions: The prevalence of LUTS (42.3%) is high. Components of Metabolic Syndrome- HDL-C, BMI, and coronary risk were associated with LUTS. This emphasizes the need for community education.
C1 [Asare, George A.; Asiedu, Bernice; Amoah, Brodrick Y.] Univ Ghana, Sch Biomed & Allied Hlth Sci SBAHS, Dept Med Lab Sci, Chem Pathol Unit, POB KB 143,Korle Bu Campus, Korle Bu, Ghana.
   [Sule, Derick S.; Oblitey, Jared N.; Ntiforo, Reese; Lamptey, Emmanuel L.; Botwe, Benard Ohene] Univ Ghana, Sch Biomed & Allied Hlth Sci SBAHS, Dept Radiog, POB KB 143,Korle Bu Campus, Korle Bu, Ghana.
   [Afriyie, Daniel K.] Ghana Police Hosp, Dept Pharm, Cantonments, Accra, Ghana.
C3 University of Ghana; University of Ghana
RP Asare, GA (corresponding author), Univ Ghana, Sch Biomed & Allied Hlth Sci SBAHS, Dept Med Lab Sci, Chem Pathol Unit, POB KB 143,Korle Bu Campus, Korle Bu, Ghana.; Botwe, BO (corresponding author), Univ Ghana, Sch Biomed & Allied Hlth Sci SBAHS, Dept Radiog, POB KB 143,Korle Bu Campus, Korle Bu, Ghana.
EM george.asare@gmail.com; sirbenard13@gmail.com
RI Asiedu, Bernice/HHC-0919-2022; Botwe, Benard/S-8697-2018
OI Oblitey, Jared/0000-0001-7123-7724; Botwe, Benard/0000-0002-0477-640X
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NR 34
TC 1
Z9 1
U1 0
U2 5
PU CELL PRESS
PI CAMBRIDGE
PA 50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA
EI 2405-8440
J9 HELIYON
JI Heliyon
PD NOV
PY 2021
VL 7
IS 11
AR e08391
DI 10.1016/j.heliyon.2021.e08391
EA NOV 2021
PG 8
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA YJ0TY
UT WOS:000744253000016
PM 34825094
OA Green Published, Green Accepted, gold
DA 2025-06-11
ER

PT J
AU Johnson, SB
   Riley, AW
   Granger, DA
   Riis, J
AF Johnson, Sara B.
   Riley, Anne W.
   Granger, Douglas A.
   Riis, Jenna
TI The Science of Early Life Toxic Stress for Pediatric Practice and
   Advocacy
SO PEDIATRICS
LA English
DT Article
DE toxic stress; health disparities; social determinants of health
ID CHILDHOOD SOCIOECONOMIC-STATUS; IMMUNE-SYSTEM; MATERNAL-CARE; EARLY
   EXPERIENCE; SOCIAL-ENVIRONMENT; METABOLIC SYNDROME; INDOOR ALLERGENS;
   CORTISOL-LEVELS; RESPONSES; CHILDREN
AB Young children who experience toxic stress are at high risk for a number of health outcomes in adulthood, including cardiovascular disease, cancers, asthma, and depression. The American Academy of Pediatrics has recently called on pediatricians, informed by research from molecular biology, genomics, immunology, and neuroscience, to become leaders in science-based strategies to build strong foundations for children's life-long health. In this report, we provide an overview of the science of toxic stress. We summarize the development of the neuroendocrine-immune network, how its function is altered by early life adversity, and how these alterations then increase vulnerability to disease. The fact that early environments shape and calibrate the functioning of biological systems very early in life is both a cautionary tale about overlooking critical periods in development and reason for optimism about the promise of intervention. Even in the most extreme cases of adversity, well-timed changes to children's environments can improve outcomes. Pediatricians are in a unique position to contribute to the public discourse on health and social welfare by explaining how factors that seem distal to child health may be the key to some of the most intractable public health problems of our generation. We consider the challenges and opportunities for preventing toxic stress in the context of contemporary pediatric practice. Pediatrics 2013;131:319-327
C1 [Johnson, Sara B.; Riley, Anne W.] Johns Hopkins Sch Med, Dept Pediat, Baltimore, MD USA.
   [Johnson, Sara B.; Granger, Douglas A.; Riis, Jenna] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Populat Family & Reprod Hlth, Baltimore, MD USA.
   [Granger, Douglas A.] Johns Hopkins Sch Nursing, Ctr Interdisciplinary Salivary Biosci Res, Dept Acute & Chron Care, Baltimore, MD USA.
C3 Johns Hopkins University; Johns Hopkins Medicine; Johns Hopkins
   University; Johns Hopkins Bloomberg School of Public Health; Johns
   Hopkins University
RP Johnson, SB (corresponding author), 200 N Wolfe St,Room 2017, Baltimore, MD 21287 USA.
EM sjohnson@jhsph.edu
RI , Sara Johnson/KZU-5191-2024
OI JOHNSON, SARA/0000-0003-4532-1847
FU National Institute on Drug Abuse [K01DA027229]
FX Dr Johnson is supported by a Career Development Award sponsored by the
   National Institute on Drug Abuse (K01DA027229).
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NR 82
TC 318
Z9 375
U1 1
U2 87
PU AMER ACAD PEDIATRICS
PI Itasca
PA 345 Park Boulevard, Itasca, IL, UNITED STATES
SN 0031-4005
EI 1098-4275
J9 PEDIATRICS
JI Pediatrics
PD FEB
PY 2013
VL 131
IS 2
BP 319
EP 327
DI 10.1542/peds.2012-0469
PG 9
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Pediatrics
GA 081XG
UT WOS:000314355100059
PM 23339224
OA Green Published
DA 2025-06-11
ER

PT J
AU Roca, J
   Tenyi, A
   Cano, I
AF Roca, Josep
   Tenyi, Akos
   Cano, Isaac
TI Paradigm changes for diagnosis: using big data for prediction
SO CLINICAL CHEMISTRY AND LABORATORY MEDICINE
LA English
DT Article; Proceedings Paper
CT 2nd Strategic Conference of the
   European-Federation-for-Clinical-Chemistry-and-Laboratory-Medicine
   (EFLM)
CY JUN 18-19, 2018
CL Mannheim, GERMANY
SP European Federat Clin Chem & Lab Med
DE big data; Integrated Care; personalized medicine; systems medicine;
   value-based healthcare
ID PATIENT; SYSTEM; CARE
AB Due to profound changes occurring in biomedical knowledge and in health systems worldwide, an entirely new health and social care scenario is emerging. Moreover, the enormous technological potential developed over the last years is increasingly influencing life sciences and driving changes toward personalized medicine and value-based healthcare. However, the current slow progression of adoption, limiting the generation of healthcare efficiencies through technological innovation, can be realistically overcome by fostering convergence between a systems medicine approach and the principles governing Integrated Care. Implicit with this strategy is the multidisciplinary active collaboration of all stakeholders involved in the change, namely: citizens, professionals with different profiles, academia, policy makers, industry and payers. The article describes the key building blocks of an open and collaborative hub currently being developed in Catalonia (Spain) aiming at generation, deployment and evaluation of a personalized medicine program addressing highly prevalent chronic conditions that often show co-occurrence, namely: cardiovascular disorders, chronic obstructive pulmonary disease, type 2 diabetes mellitus; metabolic syndrome and associated mental disturbances (anxiety-depression and altered behavioral patterns leading to unhealthy life styles).
C1 [Roca, Josep; Tenyi, Akos; Cano, Isaac] Univ Barcelona, Hosp Clin, IDIBAPS, Fac Med, C Villarroel 170, E-08036 Barcelona, Catalunya, Spain.
   [Roca, Josep; Tenyi, Akos; Cano, Isaac] Ctr Invest Biomed Red Enfermedades Resp CIBERES, Av Monforte Lemos,3-5 Pabellon 11,Planta 0, Madrid 28029, Catalunya, Spain.
C3 University of Barcelona; Hospital Clinic de Barcelona; IDIBAPS; CIBER -
   Centro de Investigacion Biomedica en Red; CIBERES
RP Roca, J (corresponding author), Univ Barcelona, Hosp Clin, IDIBAPS, Fac Med, C Villarroel 170, E-08036 Barcelona, Catalunya, Spain.; Roca, J (corresponding author), Ctr Invest Biomed Red Enfermedades Resp CIBERES, Av Monforte Lemos,3-5 Pabellon 11,Planta 0, Madrid 28029, Catalunya, Spain.
EM jroca@clinic.cat
RI Cano, Isaac/M-8507-2019; Roca, Josep/J-2583-2015
OI Roca, Josep/0000-0003-4768-8722
FU NEXTCARE [COMRDI15-1-0016]; PITES-TliSS [PI15/00576]; AGAUR research
   groups [2009SGR911, 2014SGR661]
FX Supported, in part, by NEXTCARE (COMRDI15-1-0016), PITES-TliSS
   (PI15/00576) and AGAUR research groups (2009SGR911 and 2014SGR661).
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NR 36
TC 5
Z9 6
U1 0
U2 9
PU WALTER DE GRUYTER GMBH
PI BERLIN
PA GENTHINER STRASSE 13, D-10785 BERLIN, GERMANY
SN 1434-6621
EI 1437-4331
J9 CLIN CHEM LAB MED
JI Clin. Chem. Lab. Med.
PD MAR
PY 2019
VL 57
IS 3
SI SI
BP 317
EP 327
DI 10.1515/cclm-2018-0971
PG 11
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Medical Laboratory Technology
GA HN3XV
UT WOS:000460119400004
PM 30530879
OA Bronze
DA 2025-06-11
ER

PT J
AU Samala, N
   Tersey, SA
   Chalasani, N
   Anderson, RM
   Mirmira, RG
AF Samala, Niharika
   Tersey, Sarah A.
   Chalasani, Naga
   Anderson, Ryan M.
   Mirmira, Raghavendra G.
TI Molecular mechanisms of nonalcoholic fatty liver disease: Potential role
   for 12-lipoxygenase
SO JOURNAL OF DIABETES AND ITS COMPLICATIONS
LA English
DT Review
DE Non-alcoholic fatty liver disease; Fatty liver; Lipoxygenase; Oxidative
   stress; Obesity
ID VITAMIN-E; LIPID-PEROXIDATION; INSULIN-RESISTANCE; OXIDATIVE STRESS;
   WEIGHT-LOSS; SELECTIVE INHIBITORS; METABOLIC SYNDROME; HEPATIC
   STEATOSIS; BARIATRIC SURGERY; CONTROLLED-TRIAL
AB Nonalcoholic fatty liver disease (NAFLD) is a spectrum of pathologies associated with fat accumulation in the liver. NAFLD is the most common cause of liver disease in the United States, affecting up to a third of the general population. It is commonly associated with features of metabolic syndrome, particularly insulin resistance. NAFLD shares the basic pathogenic mechanisms with obesity and insulin resistance, such as mitochondrial, oxidative and endoplasmic reticulum stress. Lipoxygenases catalyze the conversion of poly-unsaturated fatty acids in the plasma membrane mainly arachidonic acid and linoleic acid-to produce oxidized pro-inflammatory lipid intermediates. 12-Lipoxygenase (12-LOX) has been studied extensively in setting of inflammation and insulin resistance. As insulin resistance is closely associated with development of NAFLD, the role of 12-LOX in pathogenesis of NAFLD has received increasing attention in recent years. In this review we discuss the role of 12-LOX in NAFLD pathogenesis and its potential role in emerging new therapeutics. (C) 2017 Elsevier Inc. All rights reserved.
C1 [Samala, Niharika; Chalasani, Naga; Mirmira, Raghavendra G.] Indiana Univ Sch Med, Dept Med, Indianapolis, IN 46202 USA.
   [Samala, Niharika; Tersey, Sarah A.; Chalasani, Naga; Anderson, Ryan M.; Mirmira, Raghavendra G.] Indiana Univ Sch Med, Ctr Diabet & Metab Dis, Indianapolis, IN 46202 USA.
   [Tersey, Sarah A.; Anderson, Ryan M.; Mirmira, Raghavendra G.] Indiana Univ Sch Med, Dept Pediat, Indianapolis, IN 46202 USA.
   [Chalasani, Naga; Anderson, Ryan M.; Mirmira, Raghavendra G.] Indiana Univ Sch Med, Dept Cellular & Integrat Physiol, Indianapolis, IN 46202 USA.
   [Mirmira, Raghavendra G.] Indiana Univ Sch Med, Dept Biochem & Mol Biol, Indianapolis, IN 46202 USA.
C3 Indiana University System; Indiana University Bloomington; Indiana
   University System; Indiana University Bloomington; Indiana University
   System; Indiana University Bloomington; Indiana University System;
   Indiana University Bloomington; Indiana University System; Indiana
   University Bloomington
RP Mirmira, RG (corresponding author), Indiana Univ Sch Med, 635 Barnhill Dr,MS2031B, Indianapolis, IN 46202 USA.
EM rmirmira@iu.edu
RI Mirmira, Raghavendra/AAD-7592-2020
OI Tersey, Sarah/0000-0003-0667-2361
FU National Institutes of Health [R01 DK060581, R01 DK105588, UC4 DK104166]
FX Research in the Mirmira laboratory is funded by grants R01 DK060581, R01
   DK105588, and UC4 DK104166 from the National Institutes of Health.
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NR 107
TC 25
Z9 25
U1 0
U2 24
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1056-8727
EI 1873-460X
J9 J DIABETES COMPLICAT
JI J. Diabetes Complications
PD NOV
PY 2017
VL 31
IS 11
BP 1630
EP 1637
DI 10.1016/j.jdiacomp.2017.07.014
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA FL6VP
UT WOS:000414384600013
PM 28886991
OA Green Submitted, Green Accepted
DA 2025-06-11
ER

PT J
AU Han, AL
AF Han, A. Lum
TI Association between lipid ratio and depression: a cross-sectional study
SO SCIENTIFIC REPORTS
LA English
DT Article
ID HDL-CHOLESTEROL RATIO; PATIENT HEALTH QUESTIONNAIRE-9;
   HIGH-DENSITY-LIPOPROTEIN; LOW SERUM-CHOLESTEROL; METABOLIC SYNDROME;
   CARDIOVASCULAR RISK; SUICIDAL BEHAVIORS; MAJOR DEPRESSION; METAANALYSIS;
   SEROTONIN
AB Depression is associated with total cholesterol, low-density lipoprotein cholesterol, triglycerides, and high-density lipoprotein cholesterol levels in the blood. However, evidence is limited on the relationship between depression and lipid ratios. Therefore, this study aimed to investigate the correlation between depression and different lipid ratios. This study was conducted using data from the Korea National Health and Nutrition Examination Survey. A total of 11,648 adult men and women aged >= 19 years, without missing data, were included in this study. Depression was diagnosed using the Patient Health Questionnaire-9. The associations between depression and total cholesterol/high-density lipoprotein cholesterol, low-density cholesterol/high-density lipoprotein cholesterol, and triglyceride/high-density lipoprotein cholesterol ratio were analyzed. A complex sample logistic regression test was used for the analysis of the odds ratios of depression. Among men, the total cholesterol/high-density lipoprotein cholesterol and low-density cholesterol/high-density lipoprotein cholesterol ratios were not associated with depression. Additionally, an increase in triglyceride/high-density lipoprotein cholesterol ratio by 1 was associated with a 1.041-fold higher probability of depression in men. Among women, the three lipid ratios were not associated with depression. Triglyceride/high-density lipoprotein cholesterol ratio is associated with depression among men. Future studies should cross-validate, explore the biological mechanism, and identify the clinical implication of this correlation.
C1 [Han, A. Lum] Wonkwang Univ Hosp, Dept Family Med, Sinyong Dong 344-2, Iksan 54538, Jeollabuk Do, South Korea.
C3 Wonkwang University
RP Han, AL (corresponding author), Wonkwang Univ Hosp, Dept Family Med, Sinyong Dong 344-2, Iksan 54538, Jeollabuk Do, South Korea.
EM qibosarang@naver.com
FU Wonkwang University; HumanEnos LLC company; Jeonbuk Research&Development
   Program - Jeonbuk Province [RA2021-02-C3-04]
FX This research was supported by Wonkwang University (2023) and HumanEnos
   LLC company. This research was supported by a grant (RA2021-02-C3-04)
   from Jeonbuk Research&Development Program funded by Jeonbuk Province.
CR Aksay SS, 2016, J AFFECT DISORDERS, V189, P85, DOI 10.1016/j.jad.2015.09.037
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NR 33
TC 19
Z9 19
U1 0
U2 16
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD APR 13
PY 2022
VL 12
IS 1
AR 6190
DI 10.1038/s41598-022-10350-5
PG 8
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 0O8CZ
UT WOS:000783752600023
PM 35418704
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Sánchez, EP
   Corona-Pérez, A
   Arroyo-Helguera, O
   Rodríguez, IS
   Lumbreras, SRC
   Rodriguez-Antolin, J
   Romero, EC
   Nicolás-Toledo, L
AF Sanchez, Eliut Perez
   Corona-Perez, Adriana
   Arroyo-Helguera, Omar
   Rodriguez, Ida Soto
   Lumbreras, Senobia Rosalia Cruz
   Rodriguez-Antolin, Jorge
   Cuevas Romero, Estela
   Nicolas-Toledo, Leticia
TI Chronic unpredictable mild stress increases serum aldosterone without
   affecting corticosterone levels and induces hepatic steatosis and renal
   injury in young adult male rats
SO JOURNAL OF MOLECULAR HISTOLOGY
LA English
DT Article
DE Creatinine; Eplerenone; Fibrosis; Inflammation; Tubular atrophy; Urine
   sodium
ID NONALCOHOLIC FATTY LIVER; TISSUE GROWTH-FACTOR; EXPRESSION; KIDNEYS;
   DISEASE; INFLAMMATION; EPLERENONE; RECEPTOR; MODEL
AB Stress is often associated with anxiety and depressive symptoms in adolescents. Stress is associated with components of metabolic syndrome and inflammation. The present study hypothesizes that aldosterone, more than corticosterone, promotes chronic stress-hepatic steatosis and fibrosis, as well as renal inflammation and fibrosis in young adult rats. Thirty-two young adult male Wistar rats of 51 days old were divided into four groups (n = 8 per group): Control (C), chronic unpredictable mild stress (CUMS), control plus vehicle (C plus veh), CUMS plus eplerenone, a selective aldosterone blocker (CUMS plus EP). On postnatal day 51, eplerenone was administered orally through a gastric tube two hours before the start of the stress test. The CUMS paradigm was administered once daily at different times, with no repetition of the stressor sequence for four weeks. Renal inflammation and fibrosis were measured, as well as liver glycogen, triacylglycerol, and fibrosis levels. The serum concentrations of corticosterone, aldosterone, sodium, and creatinine were measured in urine and serum. The CUMS group showed a high level of serum aldosterone without affecting the level of corticosterone, increased urinary sodium, tubular atrophy, glomerular sclerosis, the presence of inflammation, and fibrosis, without affecting creatinine, increased glycogen content, triacylglycerol, and moderate fibrosis in the liver, and treatment with eplerenone prevented the inflammation, fibrosis, glycogen, and triacylglycerol. Our results show that chronic stress-induced aldosterone promotes hepatic steatosis and renal injury more than corticosterone. The prevention by eplerenone supports our hypothesis.
C1 [Sanchez, Eliut Perez] Univ Autonoma Tlaxcala, Doctorado Ciencias Biol, Tlaxcala, Mexico.
   [Sanchez, Eliut Perez] Univ Autonoma Tlaxcala, Fac Ciencias Salud, Licenciatura Med Cirujano, Tlaxcala, Mexico.
   [Corona-Perez, Adriana] Univ Autonoma Tlaxcala, Unidad Academ Multidisciplinaria Calpulalpan, Licenciatura Nutr, Tlaxcala, Mexico.
   [Arroyo-Helguera, Omar] Univ Veracruzana, Lab Biomed & Salud, Inst Salud Publ, Xalapa, Veracruz, Mexico.
   [Rodriguez, Ida Soto] Univ Veracruzana, Fac Bioanal, Veracruz, Mexico.
   [Lumbreras, Senobia Rosalia Cruz] Univ Autonoma Tlaxcala, Fac Ciencias Salud, Licenciatura Quim Clin, Tlaxcala, Mexico.
   [Rodriguez-Antolin, Jorge; Cuevas Romero, Estela; Nicolas-Toledo, Leticia] Univ Autonoma Tlaxcala, Ctr Tlaxcala Biol Conducta, Tlaxcala, Mexico.
C3 Universidad Veracruzana; Universidad Veracruzana
RP Nicolás-Toledo, L (corresponding author), Univ Autonoma Tlaxcala, Ctr Tlaxcala Biol Conducta, Tlaxcala, Mexico.
RI Corona Pérez, Adriana/KEE-6675-2024; Rodríguez-Antolín,
   Jorge/HZH-9026-2023; Estela, Cuevas-Romero/H-7856-2019; Nicolás-Toledo,
   Leticia/AAA-4587-2022; Arroyo-Helguera, Omar/A-2278-2014
OI Cuevas-Romero, Estela/0000-0003-3960-2351; Perez-Sanchez,
   Eliut/0000-0001-5653-5563
FU Project partially granted by CONACyT - Mxico
FX No Statement Available
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NR 54
TC 2
Z9 2
U1 1
U2 3
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1567-2379
EI 1567-2387
J9 J MOL HISTOL
JI J. Mol. Histol.
PD JUN
PY 2024
VL 55
IS 3
BP 265
EP 278
DI 10.1007/s10735-024-10188-3
EA APR 2024
PG 14
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA RJ9S4
UT WOS:001197888400001
PM 38583123
DA 2025-06-11
ER

PT J
AU Simeoni, U
   Zetterström, R
AF Simeoni, U
   Zetterström, R
TI Long-term circulatory and renal consequences of intrauterine growth
   restriction
SO ACTA PAEDIATRICA
LA English
DT Review
DE intrauterine growth restriction; fetal stress; renal development;
   arterial hypertension; syndrome X; maternal protein deprivation
ID LOW-PROTEIN DIET; MATERNAL FOOD RESTRICTION; RENIN-ANGIOTENSIN SYSTEM;
   LOW-BIRTH-WEIGHT; BLOOD-PRESSURE; ADULT HYPERTENSION; PRENATAL EXPOSURE;
   FETAL EXPOSURE; YOUNG; RAT
AB Intrauterine growth restriction (IUGR) and probably also early postnatal altered nutrition in very-low-birthweight babies may, in the long term, be followed by the various disorders that are included in the metabolic syndrome. This discovery has raised a new paradigm about the background to cardiovascular disease, arterial hypertension, obesity, type 2 diabetes and dyslipidaemic disorders that play a prominent role in shortening human life. In this review article, present knowledge about the background to renal dysfunction as seen in IUGR is summarized. The way in which arterial hypertension and cardiovascular dysfunction may be programmed in IUGR is also speculated.
   Conclusion: During the last decade, knowledge of the long-term consequences of IUGR has increased at a very rapid rate. At present, it is most important not only to develop efficient methods of preventing and diagnosing IUGR, but to work out follow-up and treatment programmes for the control of the disorders which may follow this condition. Proper postnatal feeding and infant growth may be essential for long-term outcome.
C1 Univ Mediterranee, Div Neonatol, APHM, Marseille, France.
   Univ Mediterranee, EA 2193, Marseille, France.
   Karolinska Univ Hosp, Stockholm, Sweden.
C3 Aix-Marseille Universite; Assistance Publique-Hopitaux de Marseille;
   Aix-Marseille Universite; Karolinska Institutet; Karolinska University
   Hospital
RP La Concept Hosp, Div Neonatol, 147 Blvd Baille, F-13385 Marseille, France.
EM umberto.simeoni@ap-hm.fr
RI SIMEONI, Umberto/AAQ-1870-2021; Simeoni, Umberto/GRO-6971-2022
OI Simeoni, Umberto/0000-0003-0730-9337
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NR 59
TC 18
Z9 21
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0803-5253
EI 1651-2227
J9 ACTA PAEDIATR
JI Acta Paediatr.
PY 2005
VL 94
IS 7
BP 819
EP 824
DI 10.1080/08035250510040223
PG 6
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA 950HB
UT WOS:000230847100001
PM 16188798
DA 2025-06-11
ER

PT J
AU Pan, QX
   Wu, JJ
   Liu, YY
   Li, XJ
   Chen, JX
AF Pan, Qiuxia
   Wu, Jiajia
   Liu, Yueyun
   Li, Xiaojuan
   Chen, Jiaxu
TI Involvement of Hepatic SHIP2 and PI3K/Akt Signalling in the Regulation
   of Plasma Insulin by Xiaoyaosan in Chronic Immobilization-Stressed Rats
SO MOLECULES
LA English
DT Article
DE chronic stress; Chinese medicinal formulae; metabolic disorders;
   insulin; lipid
ID CHRONIC RESTRAINT STRESS; EARLY-LIFE STRESS; HIGH-FAT DIET;
   METABOLIC-DISORDERS; OXIDATIVE STRESS; PKB/AKT ISOFORMS;
   LIPID-METABOLISM; ADIPOSE-TISSUE; MILD STRESS; BRAIN
AB Background: Long-term exposure to chronic stress is thought to be a factor closely correlated with the development of metabolic disorders, such as diabetes mellitus and metabolic syndrome. Xiaoyaosan, a Chinese herbal formula, has been described in many previous studies to exert anxiolytic-like or antidepressant effects in chronically stressed rats. However, few studies have observed the effects of Xiaoyaosan on the metabolic disorders induced by chronic stress. Objective: We sought to investigate the effective regulation of Xiaoyaosan on 21-day chronic immobility stress (CIS, which is 3 h of restraint immobilization every day)-induced behavioural performance and metabolic responses and to further explore whether the effects of Xiaoyaosan were related to SHIP2 expression in the liver. Methods: Sixty male Sprague Dawley rats were randomly divided into a control group, a CIS group, a Xiaoyaosan group and a rosiglitazone group. The latter three groups were subjected to 21 days of CIS to generate the stress model. After 21 days of CIS, the effects of Xiaoyaosan on body weight, food intake, and behaviour in the open field test, the sucrose preference test and the forced swimming test were observed following chronic stress. Plasma insulin, cholesterol (CHOL), triglyceride (TG), low-density lipoprotein (LDL-C) and high-density lipoprotein (HDL-C) concentrations and blood glucose were examined, and the protein and mRNA expression levels of SHIP2, p85 and Akt in the liver were measured using RT-qPCR and immunohistochemical staining. Results: Rats exposed to CIS exhibited depression-like behaviours, decreased levels of plasma insulin, CHOL, LDL-C, TG and HDL-C, and increased blood glucose. Increased SHIP2 expression and reduced Akt, p-Akt and p85 expression were also observed in the liver. Xiaoyaosan exerted antidepressant effects and effectively reversed the changes caused by CIS. Conclusions: These results suggest that Xiaoyaosan attenuates depression-like behaviours and ameliorates stress-induced abnormal levels of insulin, blood glucose, CHOL, LDL-C and HDL-C in the plasma of stressed rats, which may be associated with the regulation of SHIP2 expression to enhance PI3K/Akt signalling activity in the liver.
C1 [Pan, Qiuxia; Wu, Jiajia; Liu, Yueyun; Chen, Jiaxu] Beijing Univ Chinese Med, Sch Basic Med Sci, Beijing 100029, Peoples R China.
   [Pan, Qiuxia] China Acad Chinese Med Sci, Inst Basic Theory Chinese Med, Beijing 100700, Peoples R China.
   [Li, Xiaojuan; Chen, Jiaxu] Jinan Univ, Sch Tradit Chinese Med, Formula Pattern Res Ctr, Guangzhou 510632, Guangdong, Peoples R China.
C3 Beijing University of Chinese Medicine; Institute of Basic Theory for
   Chinese Medicine, CACMS; China Academy of Chinese Medical Sciences;
   Jinan University
RP Chen, JX (corresponding author), Beijing Univ Chinese Med, Sch Basic Med Sci, Beijing 100029, Peoples R China.; Li, XJ; Chen, JX (corresponding author), Jinan Univ, Sch Tradit Chinese Med, Formula Pattern Res Ctr, Guangzhou 510632, Guangdong, Peoples R China.
EM pqx1126@sina.com; wujiajia92@hotmail.com; chloelou@126.com;
   lixiaojuan@jnu.edu.cn; chenjiaxu@hotmail.com
RI chen, jiaojiao/KII-6749-2024
FU National Natural Science Foundation of China [81630104, 81473597]
FX This work was supported by National Natural Science Foundation of China
   (No. 81630104, 81473597).
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NR 68
TC 18
Z9 23
U1 2
U2 12
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1420-3049
J9 MOLECULES
JI Molecules
PD FEB 1
PY 2019
VL 24
IS 3
AR 480
DI 10.3390/molecules24030480
PG 17
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA HL7PR
UT WOS:000458934000104
PM 30699999
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Monfort-Pires, M
   Ferreira, SRG
AF Monfort-Pires, Milena
   Ferreira, Sandra Roberta G.
TI Modification in a single meal is sufficient to provoke benefits in
   inflammatory responses of individuals at low-to-moderate cardiometabolic
   risk
SO CLINICAL NUTRITION
LA English
DT Article
DE Dietary intervention; Saturated fatty acids; Monounsaturated fatty
   acids; Fat tolerance test; Inflammatory markers
ID INSULIN-RESISTANCE; HIGH-FAT; CARDIOVASCULAR-DISEASE;
   MONOUNSATURATED-FAT; MEDITERRANEAN DIET; OXIDATIVE STRESS; E-SELECTIN;
   MEN; TRIGLYCERIDES; OVERWEIGHT
AB Background & aims: Postprandial state is characterized by metabolic changes which may elevate circulating inflammatory biomarkers, used to assess cardiometabolic risk. It is unclear if biological benefits of certain food components could be obtained by a short-term change in a single meal of Brazilian's habitual diet We investigated the postprandial effects of 2 fat tolerance tests (FTT) with different isocaloric meals (a typical Brazilian and a modified meal) differing by type of fatty acids and fiber contents, prior to and after breakfast interventions.
   Methods: This crossover clinical trial included 80 overweight individuals with at least one 'cardiometabolic risk factor, (35-69 years) who received two isocaloric breakfast interventions for 4 weeks, with a 2 -week washout The Brazilian breakfast was saturated fat-enriched while the modified 'one was rich in unsaturated fatty acids and fibers. Before and after intervention periods, individuals underwent two-FTT with meals with similar composition to the interventions breakfasts but higher energy content Variables were compared by repeated-measures ANOVA. Correlations were assessed by Pearson's coefficient.
   Results: At the end of both interventions, participants did not change plasma glucose or triglycerides. The higher IL-6 and IL-8 responses to the FIT with the Brazilian meal compared to that with the modified meal was accentuated after the interventions (p-diet <0.01; p-time <0.01). Acutely, E-selectin, TNF-alpha, IFN-gamma, IL-10 and IL-17 concentrations did not increase in response to the FTTs, but showed higher values only after the Brazilian intervention. In contrast, intervention with the modified breakfast induced reductions in fasting and postprandial cytokines (p-diet <0.01). Changes in MUFA and PUFA intakes were inversely correlated to changes in inflammatory markers, while changes in saturated fat intake were directly correlated to IFN-gamma and IL-6.
   Conclusion: Isocaloric meals with distinct nutrient composition elicit different postprandial inflammatory responses after a relatively short intervention in a single meal. Each saturated fat-enriched meal consumed, as well as each unsaturated fat and fiber-enriched meal may induce pro- or anti-inflammatory responses that could impact on the cardiometabolic risk profile. (C) 2016 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.
C1 [Monfort-Pires, Milena] Univ Sao Paulo, Sch Publ Hlth, Dept Nutr, Sao Paulo, Brazil.
   [Ferreira, Sandra Roberta G.] Univ Sao Paulo, Sch Publ Hlth, Dept Epidemiol, Sao Paulo, Brazil.
C3 Universidade de Sao Paulo; Universidade de Sao Paulo
RP Ferreira, SRG (corresponding author), Univ Sao Paulo, Fac Saude Publ, Dept Epidemiol, Av Dr Arnaldo 715, BR-01246904 Sao Paulo, SP, Brazil.
EM sandrafv@usp.br
RI Ferreira, Sandra/B-9840-2012
OI Monfort-Pires, Milena/0000-0002-1652-8083; Ferreira,
   Sandra/0000-0002-7015-7391
FU Sao Paulo Foundation for Research Support - FAPESP (Brazil)
   [2012/05487-2, 2012/05503-8]; Fundacao de Amparo a Pesquisa do Estado de
   Sao Paulo (FAPESP) [12/05503-8, 12/05487-2] Funding Source: FAPESP;
   Swedish Research Council [2012-05503] Funding Source: Swedish Research
   Council
FX This work was supported by a grant from The Sao Paulo Foundation for
   Research Support - FAPESP (Brazil) (Grant number: 2012/05487-2;
   2012/05503-8).
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NR 30
TC 14
Z9 16
U1 0
U2 12
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0261-5614
EI 1532-1983
J9 CLIN NUTR
JI Clin. Nutr.
PD DEC
PY 2016
VL 35
IS 6
BP 1242
EP 1250
DI 10.1016/j.clnu.2016.02.015
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA EC3UI
UT WOS:000388051900005
PM 26987426
DA 2025-06-11
ER

PT J
AU Singh, H
   Giridharan, N
   Bhonde, R
   Venkatesan, V
AF Singh, Himadri
   Giridharan, Nappanveettil
   Bhonde, Ramesh
   Venkatesan, Vijayalakshmi
TI Deriving at candidate genes of metabolic stress from pancreas of
   WNIN/GR-Ob mutant rats
SO ISLETS
LA English
DT Article
DE WNIN; GR-Ob rats; inflammation; insulin resistance; obesity; type 2
   diabetes
ID ENDOPLASMIC-RETICULUM; OXIDATIVE STRESS; ANIMAL-MODELS; BETA-CELLS;
   OBESITY; EXPRESSION; GLUCOKINASE
AB Development of appropriate animal model systems have greatly helped our understanding of the basic mechanism(s) of several degenerative diseases. WNIN/GR-Oba mutant rat strain developed at the National Center for Laboratory Animal Sciences facility of National Institute of Nutrition, is a new animal model ideal to study the metabolic syndrome since it is obese with impaired glucose tolerance and also exhibits several secondary complications. The present study was performed in the pancreas of this mutant model to assess the global gene expression (microarray) to assess the transcriptome level changes in situ depicting inflammation, obesity, insulin resistance, and diabetes in these animals. Our findings suggest an interplay of several confounding factors in pancreas which include inflammation /macrophage infiltration/apoptosis/oxidative and endoplasmic reticulum stress, all contributing for the shift toward pro-inflammation. We were able to phenotypically correlate the metabolic alterations vis-a-vis candidate genes (array analyses) compared between mutants and its age matched, parental controls. We advocate that the data reported here would provide a suitable insight in to the pathophysiology of metabolic syndrome .
C1 [Singh, Himadri; Venkatesan, Vijayalakshmi] Natl Inst Nutr ICMR, Hyderabad, Andhra Pradesh, India.
   [Giridharan, Nappanveettil] Indian Council Med Res, Natl Ctr Lab Anim Sci, Hyderabad, Andhra Pradesh, India.
   [Bhonde, Ramesh] Manipal Univ, Manipal Inst Regenerat Med, Bangalore, Karnataka, India.
C3 Indian Council of Medical Research (ICMR); ICMR - National Institute of
   Nutrition (NIN); Indian Council of Medical Research (ICMR); ICMR -
   National Animal Resource Facility for Biomedical Research (NARFBR);
   Manipal Academy of Higher Education (MAHE)
RP Venkatesan, V (corresponding author), Natl Inst Nutr ICMR, Hyderabad, Andhra Pradesh, India.
EM v.venkateshan@gmail.com
RI ; Singh, Himadri/G-1023-2012
OI Venkatesan, Vijayalakhsmi/0000-0002-3142-9657; Singh,
   Himadri/0000-0002-2354-6474
FU ICMR Junior Research Fellowship [3/1/3/JRF-2009/MPD]
FX The authors wish to thank the Directors of the of National Institute of
   Nutrition (ICMR) Department of Health Research, Govt. of India,
   Hyderabad for extending their support to carry out this work. HS is a
   recipient of ICMR Junior Research Fellowship (letter no
   3/1/3/JRF-2009/MPD Dated 27.11.2009).
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NR 33
TC 7
Z9 7
U1 0
U2 4
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1938-2014
EI 1938-2022
J9 ISLETS
JI Islets
PD JUL 1
PY 2013
VL 5
IS 4
BP 133
EP 138
DI 10.4161/isl.25520
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 258CQ
UT WOS:000327437100001
PM 24131929
OA Bronze
DA 2025-06-11
ER

PT J
AU Ojetola, AA
   Adeyemi, WJ
   David, UE
   Ajibade, TO
   Adejumobi, OA
   Omobowale, TO
   Oyagbemi, AA
   Fasanmade, AA
AF Ojetola, Abodunrin Adebayo
   Adeyemi, Wale Johnson
   David, Ubong Edem
   Ajibade, Temitayo Olabisi
   Adejumobi, Olumuyiwa Abiola
   Omobowale, Temidayo Olutayo
   Oyagbemi, Ademola Adetokunbo
   Fasanmade, Adesoji Adedipe
TI D-ribose-L-cysteine prevents oxidative stress and cardiometabolic
   syndrome in high fructose high fat diet fed rats
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Article
DE D-ribose-L-cysteine; Oxidative stress; Metabolic syndrome; High fat;
   High fructose
ID INDUCED METABOLIC SYNDROME; INSULIN-RESISTANCE; HYPERTENSION;
   GLUTATHIONE; PLASMA; ANTIOXIDANT; DEFICIENCY; PRODRUGS; GLUCOSE; MODEL
AB Cardiometabolic syndrome has been linked with dietary modification. Therefore, we investigated the effects of D-ribose-L-cysteine (DRLC) in rats fed with high fructose high fat (HFHF) diet. Twenty rats (n = 5), divided into 4 groups were concurrently exposed to HFHF and/or DRLC (250 mg/kg, p.o) during the 8 weeks study. The result showed that compared to control group, HFHF group had significant impairment in lipid and glucose homeostasis, increased cardiac xanthine oxidase, systolic blood pressure, heart rate, %body weight change and fluid intake. Also, there were significant reductions in HDL-C, cardiac (GPX, NO&GGT), feed intake and relative heart weight in the latter, relative to the former. However, there were no significant differences in most of the observed physical and biochemical changes in HFHF + DRLC group compared to control. DRLC alone did not disrupt the level of biomarkers. Conclusively, DRLC prevented the manifestation of oxidative stress and cardiometabolic syndrome in HFHF-diet fed rats.
C1 [Ojetola, Abodunrin Adebayo; David, Ubong Edem; Fasanmade, Adesoji Adedipe] Univ Ibadan, Dept Physiol, Fac Basic Med Sci, Ibadan, Nigeria.
   [Ojetola, Abodunrin Adebayo; Adeyemi, Wale Johnson] Redeemers Univ, Dept Physiol, Fac Basic Med Sci, Ede, Nigeria.
   [Ajibade, Temitayo Olabisi; Adejumobi, Olumuyiwa Abiola; Omobowale, Temidayo Olutayo; Oyagbemi, Ademola Adetokunbo] Univ Ibadan, Dept Vet Med, Fac Vet Med, Ibadan, Nigeria.
C3 University of Ibadan; Redeemers University; University of Ibadan
RP Ojetola, AA (corresponding author), Univ Ibadan, Dept Physiol, Fac Basic Med Sci, Ibadan, Nigeria.
EM bodunrin.ojetola@gmail.com
RI Ojetola, Abodunrin/HGU-3972-2022; Oyagbemi, Ademola/AAU-6326-2021;
   David, Ubong/CAA-1881-2022; Ojetola, Abodunrin Adebayo/AFV-7473-2022;
   Omobowale, Temidayo/LIH-1130-2024
OI Ojetola, Abodunrin Adebayo/0000-0002-2374-5748; Omobowale,
   Temidayo/0000-0002-9486-2861; David, Ubong/0000-0001-6589-2132
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NR 55
TC 7
Z9 8
U1 0
U2 3
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD OCT
PY 2021
VL 142
AR 112017
DI 10.1016/j.biopha.2021.112017
EA AUG 2021
PG 7
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA UW7VG
UT WOS:000700360200005
PM 34399203
OA gold
DA 2025-06-11
ER

PT J
AU Lucas, K
   Maes, M
AF Lucas, Kurt
   Maes, Michael
TI Role of the Toll Like Receptor (TLR) Radical Cycle in Chronic
   Inflammation: Possible Treatments Targeting the TLR4 Pathway
SO MOLECULAR NEUROBIOLOGY
LA English
DT Review
DE Toll-like receptor; LPS; Inflammation; Oxidative and nitrosative stress;
   Cytokines; Depression; Chronic fatigue
ID GRAM-NEGATIVE ENTEROBACTERIA; OXIDATIVE STRESS; SIGNALING PATHWAY;
   AIRWAY HYPERRESPONSIVENESS; INTESTINAL PERMEABILITY; N-ACETYLCYSTEINE;
   SALVIANOLIC ACID; IMMUNE-RESPONSE; DOUBLE-BLIND; LUNG INJURY
AB Activation of the Toll-like receptor 4 (TLR4) complex, a receptor of the innate immune system, may underpin the pathophysiology of many human diseases, including asthma, cardiovascular disorder, diabetes, obesity, metabolic syndrome, autoimmune disorders, neuroinflammatory disorders, schizophrenia, bipolar disorder, autism, clinical depression, chronic fatigue syndrome, alcohol abuse, and toluene inhalation. TLRs are pattern recognition receptors that recognize damage-associated molecular patterns and pathogen-associated molecular patterns, including lipopolysaccharide (LPS) from gram-negative bacteria. Here we focus on the environmental factors, which are known to trigger TLR4, e.g., ozone, atmosphere particulate matter, long-lived reactive oxygen intermediate, pentachlorophenol, ionizing radiation, and toluene. Activation of the TLR4 pathways may cause chronic inflammation and increased production of reactive oxygen and nitrogen species (ROS/RNS) and oxidative and nitrosative stress and therefore TLR-related diseases. This implies that drugs or substances that modify these pathways may prevent or improve the abovementioned diseases. Here we review some of the most promising drugs and agents that have the potential to attenuate TLR-mediated inflammation, e.g., anti-LPS strategies that aim to neutralize LPS (synthetic anti-LPS peptides and recombinant factor C) and TLR4/MyD88 antagonists, including eritoran, CyP, EM-163, epigallocatechin-3-gallate, 6-shogaol, cinnamon extract, N-acetylcysteine, melatonin, and molecular hydrogen. The authors posit that activation of the TLR radical (ROS/RNS) cycle is a common pathway underpinning many "civilization" disorders and that targeting the TLR radical cycle may be an effective method to treat many inflammatory disorders.
C1 [Maes, Michael] Piyavate Hosp, Bangkok, Thailand.
   [Maes, Michael] Chulalongkorn Univ, Dept Psychiat, Bangkok, Thailand.
   [Maes, Michael] Int PNI Reference Ctr, Roosendaal, Netherlands.
   [Maes, Michael] Deakin Univ, Dept Psychiat, Geelong, Vic 3217, Australia.
C3 Chulalongkorn University; Deakin University
RP Maes, M (corresponding author), Chulalongkorn Univ, Dept Psychiat, Por Bor Ror Bldg 12, Bangkok, Thailand.
EM dr.michaelmaes@hotmail.com
RI Maes, Michael/B-8546-2011
OI Maes, Michael/0000-0002-2012-871X
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NR 138
TC 377
Z9 418
U1 3
U2 307
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0893-7648
EI 1559-1182
J9 MOL NEUROBIOL
JI Mol. Neurobiol.
PD AUG
PY 2013
VL 48
IS 1
BP 190
EP 204
DI 10.1007/s12035-013-8425-7
PG 15
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 187SG
UT WOS:000322138900019
PM 23436141
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Murugappan, G
   Li, SF
   Leonard, SA
   Winn, VD
   Druzin, ML
   Eisenberg, ML
AF Murugappan, Gayathree
   Li, Shufeng
   Leonard, Stephanie A.
   Winn, Virginia D.
   Druzin, Maurice L.
   Eisenberg, Michael L.
TI Association of preconception paternal health and adverse maternal
   outcomes among healthy mothers
SO AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM
LA English
DT Article
DE adverse pregnancy outcomes; maternal health; maternal morbidity;
   paternal health; preconception paternal health
ID CONTRACEPTION; MORBIDITY; ECLAMPSIA; RISK; AGE
AB BACKGROUND: Maternal morbidity continues to be an issue of national and global concern. Paternal preconception health may play a significant role in pregnancy outcomes and has received less attention than maternal health.
   OBJECTIVE: This study aimed to examine the association between preconception paternal health and the risk for adverse maternal outcomes among healthy mothers.
   STUDY DESIGN: This was a retrospective analysis of live births from 2009 through 2016 to healthy women aged 20 to 45 years recorded in the IBM Marketscan research database. Infants were linked to paired mothers and fathers using family ID. Preconception paternal health was assessed using the number of metabolic syndrome component diagnoses and the most common individual chronic disease diagnoses (hypertension, diabetes mellitus, obesity, hyperlipidemia, chronic obstructive pulmonary disease, cancer, and depression). Women with metabolic syndrome components were excluded to avoid potential confounding of maternal and paternal factors. Adverse maternal outcomes that were assessed included (1) abnormal placentation including placenta accreta spectrum, placenta previa, and placental abruption; (2) preeclampsia with and without severe features including eclampsia; and (3) severe maternal morbidity, identified as any indicator from the Centers for Disease Control and Prevention Index of life-threatening complications at the time of delivery to 6 weeks postpartum. The trend between preconception paternal health and each maternal outcome was determined using the Cochran-Armitage Trend test. The independent association of paternal health with maternal outcomes was also determined using generalized estimating equations models, accounting for some mothers who contributed multiple births during the study period, and by adjusting for maternal age, paternal age, region of birth, year of birth, maternal smoking, and average number of outpatient visits per year.
   RESULTS: Among 669,256 births to healthy mothers, there was a significant trend between all adverse maternal outcomes and worsening preconception paternal health defined either as the number of metabolic syndrome diagnoses or number of chronic disease diagnoses (P<.001; Cochran-Armitage Trend test). In the generalized estimating equations model, the odds for preeclampsia without severe features increased in a dose-dependent fashion and were 21% higher (95% confidence interval, 1.17-1.26) among women whose partners had >= 2 metabolic syndrome diagnoses than among women whose partners had no metabolic syndrome diagnosis. The odds for preeclampsia with severe features and eclampsia increased in a dose-dependent fashion and were 19% higher (95% confidence interval, 1.09-1.30) among women whose partners had >= 2 metabolic syndrome diagnoses than among women whose partners had no metabolic syndrome diagnosis. The odds for severe maternal morbidity were 9% higher (95% confidence interval, 1.002-1.19) among women whose partners had >= 2 metabolic syndrome diagnoses than among women whose partners had no metabolic syndrome diagnosis. The odds for abnormal placentation were similar between the groups (adjusted odds ratio, 0.96; 95% confidence interval, 0.89-1.03).
   CONCLUSION: Among healthy mothers, we report that preconception paternal health is significantly associated with increased odds of preeclampsia with and without severe features and weakly associated with increased odds of severe maternal morbidity. These findings suggest that paternally derived factors may play significant roles in the development of adverse maternal outcomes in healthy women with a low a priori risk of obstetrical complications.
C1 [Murugappan, Gayathree] Stanford Univ, Div Reprod Endocrinol, Stanford, CA 94305 USA.
   [Leonard, Stephanie A.; Winn, Virginia D.; Druzin, Maurice L.] Stanford Univ, Div Maternal Fetal Med, Stanford, CA 94305 USA.
   [Li, Shufeng; Eisenberg, Michael L.] Stanford Univ, Dept Urol, Stanford, CA USA.
C3 Stanford University; Stanford University; Stanford University
RP Murugappan, G (corresponding author), Stanford Univ, Div Reprod Endocrinol, Stanford, CA 94305 USA.
EM gm807@stanford.edu
OI Murugappan, Gaya/0000-0003-4084-0365; Winn,
   Virginia/0000-0003-1136-2907; Leonard, Stephanie/0000-0001-8213-1319;
   Druzin, Maurice/0000-0001-7185-6664
FU Eunice Kennedy Shriver National Institute of Child Health and Human
   Development [1K12HD103084]; Stanford Maternal and Child Health Research
   Institute; H&H Evergreen Foundation
FX This study received funding from the Eunice Kennedy Shriver National
   Institute of Child Health and Human Development under award number
   1K12HD103084 and the Stanford Maternal and Child Health Research
   Institute (for G.M.) and from the H&H Evergreen Foundation (for V.
   D.W.).
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NR 39
TC 11
Z9 12
U1 2
U2 10
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2589-9333
J9 AM J OBST GYNEC MFM
JI Amer. J. Obstet. Gynecol. MFM
PD SEP
PY 2021
VL 3
IS 5
AR 100384
DI 10.1016/j.ajogmf.2021.100384
EA JUL 2021
PG 8
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA WM7BK
UT WOS:000711236400017
PM 33895399
DA 2025-06-11
ER

PT J
AU Lahti, J
   Ala-Mikkula, H
   Kajantie, E
   Haljas, K
   Eriksson, JG
   Räikkönen, K
AF Lahti, Jari
   Ala-Mikkula, Heidi
   Kajantie, Eero
   Haljas, Kadri
   Eriksson, Johan G.
   Raikkonen, Katri
TI Associations Between Self-Reported and Objectively Recorded Early Life
   Stress, FKBP5 Polymorphisms, and Depressive Symptoms in Midlife
SO BIOLOGICAL PSYCHIATRY
LA English
DT Article
DE Cortisol; Depression; Early life stress; FKBP5; HPA; Longitudinal study;
   Separation
ID ENVIRONMENT INTERACTION; METABOLIC SYNDROME; GENE; CHILDHOOD; EVENTS;
   METHYLATION; CHILDREN; ABUSE; RISK; EXPERIENCES
AB BACKGROUND: FK506-binding protein 51 is involved in hypothalamic-pituitary-adrenal axis regulation. Single nucleotide polymorphisms (SNPs) in the FKBP5 gene have been shown to interact with retrospectively self-reported early life stress (ELS) in patients with psychiatric disorders. We examined interactions between three selected FKBP5 SNPs and self-reported and objectively recorded ELS in relation to depressive symptoms in midlife.
   METHODS: This study comprised 1431 Helsinki Birth Cohort Study participants genotyped for FKBP5 SNPs shown to alter cortisol metabolism (rs1360780, rs9470080, and rs9394309). Participants completed the Beck Depression Inventory (BDI) at ages 61.5 years (time 1) and 63.4 years (time 2); 165 and 181 participants were separated from their parents in childhood as a result of evacuations during World War II as indicated by self-reports and the Finnish National Archives registry, respectively.
   RESULTS: Associations between self-reported and objectively recorded ELS, but not stressful events in midlife, and the mean BDI score (average of time 1 and time 2) or mild to severe BDI scores (10-63 points at time 1 and time 2), or both, were moderated by the FKBP5 variants (p values for interactions <.05; p values between self-reported and objectively recorded ELS in these interactions >.18). Mean BDI scores or odds for having mild to severe BDI scores, or both, increased according to number of minor alleles and haplotypes derived from these alleles in the separated groups, but not in the nonseparated groups.
   CONCLUSIONS: FKBP5 variations in combination with self-reported and objectively recorded ELS predict more pronounced depressive symptoms in midlife. Our findings confirm previous retrospective findings in a prospective epidemiologic study setting.
C1 [Lahti, Jari; Ala-Mikkula, Heidi; Haljas, Kadri; Raikkonen, Katri] Univ Helsinki, Inst Behav Sci, FIN-00014 Helsinki, Finland.
   [Lahti, Jari; Eriksson, Johan G.] Folkhalsan Res Ctr, Helsinki, Finland.
   [Kajantie, Eero; Eriksson, Johan G.] Inst Hlth & Welf, Helsinki, Finland.
   [Kajantie, Eero] Helsinki Univ Cent Hosp, Hosp Children & Adolescents, Helsinki, Finland.
   [Kajantie, Eero] Univ Helsinki, Helsinki, Finland.
   [Kajantie, Eero] Oulu Univ Hosp, Dept Obstet & Gynecol, Oulu, Finland.
   [Kajantie, Eero] Univ Oulu, Oulu, Finland.
   [Eriksson, Johan G.] Univ Helsinki, Dept Gen Practice & Primary Hlth Care, Helsinki, Finland.
   [Eriksson, Johan G.] Vaasa Cent Hosp, Vaasa, Finland.
   [Eriksson, Johan G.] Univ Helsinki, Cent Hosp, Unit Gen Practice, Helsinki, Finland.
C3 University of Helsinki; Folkhalsan Research Center; University of
   Helsinki; Helsinki University Central Hospital; University of Helsinki;
   University of Oulu; University of Oulu; University of Helsinki; Vaasa
   Central Hospital; University of Helsinki; Helsinki University Central
   Hospital
RP Lahti, J (corresponding author), Univ Helsinki, Inst Behav Sci, FIN-00014 Helsinki, Finland.
EM jari.lahti@helsinki.fi
RI Lahti, Jari/P-2283-2019; Gibbs, J. Raphael/A-3984-2010; Lahti,
   Jari/P-7987-2018
OI Eriksson, Johan/0000-0002-2516-2060; Lahti, Jari/0000-0002-4310-5297;
   Raikkonen, Katri/0000-0003-3124-3470
FU Academy of Finland, Graduate School of Psychology, Learning and
   Education; University of Helsinki Research Funds; EraNet; Alfred
   Kordelin Foundation; Ella and Georg Ehrnrooths Stiftelse; Yrjo Jahnsson
   Foundation
FX This work was supported by the Academy of Finland, Graduate School of
   Psychology, Learning and Education, University of Helsinki Research
   Funds, EraNet, Alfred Kordelin Foundation, Ella and Georg Ehrnrooths
   Stiftelse, and Yrjo Jahnsson Foundation.
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NR 41
TC 26
Z9 27
U1 1
U2 18
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0006-3223
EI 1873-2402
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD DEC 1
PY 2016
VL 80
IS 11
BP 869
EP 877
DI 10.1016/j.biopsych.2015.10.022
PG 9
WC Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA EA9CK
UT WOS:000386938400012
PM 26740367
OA hybrid
DA 2025-06-11
ER

PT J
AU Bradley, AJ
   Dinan, TG
AF Bradley, Andrew J.
   Dinan, Timothy G.
TI A systematic review of hypothalamic-pituitary-adrenal axis function in
   schizophrenia: implications for mortality
SO JOURNAL OF PSYCHOPHARMACOLOGY
LA English
DT Review
DE Coronary heart disease; cortisol; hypothalamic-pituitary-adrenal axis;
   metabolic syndrome; mortality; schizophrenia
ID DEXAMETHASONE-SUPPRESSION TEST; DRUG-NAIVE PATIENTS;
   CORTICOTROPIN-RELEASING-FACTOR; SALIVARY CORTISOL DETERMINATIONS;
   POSTTRAUMATIC-STRESS-DISORDER; FACTOR-LIKE IMMUNOREACTIVITY; MAJOR
   DEPRESSIVE DISORDER; PSYCHIATRIC MENTAL STATUS; VISCERAL FAT
   DISTRIBUTION; MINOR PHYSICAL ANOMALIES
AB There is convincing evidence that environmental stress plays a significant role in modifying both mental and physical health. The biological mechanisms linking stress to ill health are not fully understood, but significant evidence points to a central role of the stress axes; the hypothalamic-pituitary-adrenal (HPA) axis and the sympathetic nervous system. Together these two systems link the brain and the body and are crucial in maintaining homeostasis as well as improving an organism's survival chances in the face of environmental challenge. There is evidence of altered HPA axis function in people with a range of mental disorders, and this may in part explain the poor physical health of people with psychotic, mood and anxiety disorders. This paper systematically reviews HPA axis function in people with schizophrenia and relates this to the pattern of physical health seen in this disease. In summary, the evidence suggests people with schizophrenia can experience both hyper- and hypo-function of the HPA axis. It is likely that this contributes to the pattern of poor physical health and premature mortality suffered by people with schizophrenia, in particular the high rates of cardiovascular and metabolic disturbance.
C1 [Bradley, Andrew J.] Eli Lilly & Co Ltd, Basingstoke RG24 9NL, Hants, England.
   [Dinan, Timothy G.] Cork Univ Hosp, Dept Psychiat, Cork, Ireland.
C3 Eli Lilly; University College Cork
RP Bradley, AJ (corresponding author), Eli Lilly & Co Ltd, Lilly House,Priestly Rd, Basingstoke RG24 9NL, Hants, England.
EM bradley_andrew_j@lilly.com
RI Dinan, Timothy/ABA-8284-2020
OI Dinan, Timothy/0000-0002-2316-7220
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NR 236
TC 204
Z9 223
U1 0
U2 39
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0269-8811
EI 1461-7285
J9 J PSYCHOPHARMACOL
JI J. Psychopharmacol.
PD NOV
PY 2010
VL 24
IS 11
SU S
BP 91
EP 118
DI 10.1177/1359786810385491
PG 28
WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA 679WF
UT WOS:000284190800011
PM 20923924
OA Green Published
DA 2025-06-11
ER

PT J
AU Mercurio, V
   Cuomo, A
   Dessalvi, CC
   Deidda, M
   Di Lisi, D
   Novo, G
   Manganaro, R
   Zito, C
   Santoro, C
   Ameri, P
   Spallarossa, P
   Arboscello, E
   Tocchetti, CG
   Penna, C
AF Mercurio, Valentina
   Cuomo, Alessandra
   Cadeddu Dessalvi, Christian
   Deidda, Martino
   Di Lisi, Daniela
   Novo, Giuseppina
   Manganaro, Roberta
   Zito, Concetta
   Santoro, Ciro
   Ameri, Pietro
   Spallarossa, Paolo
   Arboscello, Eleonora
   Tocchetti, Carlo Gabriele
   Penna, Claudia
TI Redox Imbalances in Ageing and Metabolic Alterations: Implications in
   Cancer and Cardiac Diseases. An Overview from the Working Group of
   Cardiotoxicity and Cardioprotection of the Italian Society of Cardiology
   (SIC)
SO ANTIOXIDANTS
LA English
DT Review
DE cancer; cardiovascular toxicity from anticancer drugs; cardiovascular
   disease; ageing; metabolic syndrome
ID DOXORUBICIN-INDUCED CARDIOTOXICITY; VISCERAL ADIPOSE-TISSUE; BODY-MASS
   INDEX; BREAST-CANCER; OXIDATIVE STRESS; HEART-FAILURE; INDUCED
   CARDIOMYOPATHY; ADJUVANT CHEMOTHERAPY; PROSTATE-CANCER; FREE-RADICALS
AB Metabolic syndrome (MetS) is a well established risk factor for cardiovascular (CV) diseases. In addition, several studies indicate that MetS correlates with the increased risk of cancer in adults. The mechanisms linking MetS and cancer are not fully understood. Several risk factors involved in MetS are also cancer risk factors, such as the consumption of high calorie-food or high fat intake, low fibre intake, and sedentary lifestyle. Other common aspects of both cancer and MetS are oxidative stress and inflammation. In addition, some anticancer treatments can induce cardiotoxicity, including, for instance, left ventricular (LV) dysfunction and heart failure (HF), endothelial dysfunction and hypertension. In this review, we analyse several aspects of MetS, cancer and cardiotoxicity from anticancer drugs. In particular, we focus on oxidative stress in ageing, cancer and CV diseases, and we analyse the connections among CV risk factors, cancer and cardiotoxicity from anticancer drugs.
C1 [Mercurio, Valentina; Cuomo, Alessandra; Tocchetti, Carlo Gabriele] Univ Naples Federico II, Dept Translat Med Sci, I-80131 Naples, Italy.
   [Cadeddu Dessalvi, Christian; Deidda, Martino] Univ Cagliari, Dept Med Sci & Publ Hlth, I-09042 Cagliari, Italy.
   [Di Lisi, Daniela; Novo, Giuseppina] Univ Palermo, Cardiol Unit AUOP Policlin, Dept Hlth Promot Mother & Child Care, Internal Med & Med Specialties, I-90127 Palermo, Italy.
   [Manganaro, Roberta; Zito, Concetta] Univ Messina, Cardiol Coronary Intens Care Unit, Dept Clin & Expt Med, Univ Hosp Policlin G Martino, I-98124 Messina, Italy.
   [Santoro, Ciro] Univ Naples Federico II, Dept Adv Biomed Sci, I-80131 Naples, Italy.
   [Ameri, Pietro; Spallarossa, Paolo; Arboscello, Eleonora] IRCCS Osped Policlin San Martino, Cardiovasc Dis Unit, Genoa, Italy.
   [Ameri, Pietro; Spallarossa, Paolo; Arboscello, Eleonora] Univ Genoa, IRCCS Italian Cardiovasc Network, I-16121 Genoa, Italy.
   [Ameri, Pietro; Spallarossa, Paolo; Arboscello, Eleonora] Univ Genoa, Dept Internal Med, I-16121 Genoa, Italy.
   [Tocchetti, Carlo Gabriele] Univ Naples Federico II, Interdept Ctr Clin & Translat Sci, I-80131 Naples, Italy.
   [Penna, Claudia] Univ Turin, Dept Clin & Biol Sci, I-10043 Turin, Italy.
C3 University of Naples Federico II; University of Cagliari; University of
   Palermo; University of Messina; University of Naples Federico II;
   University of Genoa; IRCCS AOU San Martino IST; University of Genoa;
   University of Genoa; University of Naples Federico II; University of
   Turin
RP Tocchetti, CG (corresponding author), Univ Naples Federico II, Dept Translat Med Sci, I-80131 Naples, Italy.; Tocchetti, CG (corresponding author), Univ Naples Federico II, Interdept Ctr Clin & Translat Sci, I-80131 Naples, Italy.; Penna, C (corresponding author), Univ Turin, Dept Clin & Biol Sci, I-10043 Turin, Italy.
EM valemercurio@yahoo.com; alebcuomo@gmail.com; cadedduc@unica.it;
   martino.deidda@tiscali.it; danydilis@hotmail.it;
   giuseppina.novo@unipa.it; manganaro.roberta@gmail.com; czito@unime.it;
   cirohsantoro@gmail.com; pietroameri@unige.it;
   paolo.spallarossa@unige.it; eleonora.arboscello@alice.it;
   carlogabriele.tocchetti@unina.it; claudia.penna@unito.it
RI Cuomo, Alessandra/AFC-1205-2022; Manganaro, Roberta/L-7893-2019; Penna,
   Claudia/J-5103-2018; Deidda, Martino/V-4453-2019; Cadeddu,
   Christian/AAI-9219-2020; novo, giuseppina/K-6580-2016; Lisi,
   Daniela/ABE-9175-2020; Deidda, Martino/L-3166-2015; Tocchetti, Carlo
   Gabriele/AAG-5944-2020; Stefanadis, Christodoulos/ABH-2232-2020; Ameri,
   Pietro/K-8556-2016
OI Deidda, Martino/0000-0002-3725-7614; Tocchetti, Carlo
   Gabriele/0000-0001-5983-688X; Stefanadis,
   Christodoulos/0000-0001-5974-6454; Cadeddu,
   Christian/0000-0002-2823-1797; Ameri, Pietro/0000-0001-7167-7287;
   Santoro, Ciro/0000-0002-6329-1680; arboscello,
   eleonora/0000-0002-4052-0807; Mercurio, Valentina/0000-0002-9448-2762;
   Cuomo, Alessandra/0000-0002-5781-2865
FU University of Torino, Italy; MIUR [PENC_FFABR_17_01]
FX This study was supported in part by Grant in Aid for Scientific
   Research. C.P was supported by the University of Torino, Italy
   (PENC_RILO) and by MIUR (PENC_FFABR_17_01).
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NR 159
TC 25
Z9 25
U1 0
U2 8
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD JUL
PY 2020
VL 9
IS 7
AR 641
DI 10.3390/antiox9070641
PG 20
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA MV7HL
UT WOS:000556524000001
PM 32708201
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Sjöstrand, M
   Eriksson, JW
AF Sjostrand, Mikaela
   Eriksson, Jan W.
TI Neuroendocrine mechanisms in insulin resistance
SO MOLECULAR AND CELLULAR ENDOCRINOLOGY
LA English
DT Article
DE Neuroendocrine; Stress; Insulin resistance; Adipose tissue
ID 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1; EARLY AUTONOMIC
   DYSFUNCTION; GROWTH-HORMONE TREATMENT; HEART-RATE-VARIABILITY; IN-VITRO
   REVERSAL; FREE FATTY-ACIDS; SKELETAL-MUSCLE; METABOLIC SYNDROME;
   OXIDATIVE STRESS; NERVOUS-SYSTEM
AB Dysregulated hormonal. metabolic and neural signalling within and between organs can contribute to development of metabolic diseases including type 2 diabetes. Insulin-antagonistic effects of hormones, cytokines and excess metabolic substrates such as glucose and fatty acids may be exerted via common mechanisms involving for example reactive oxygen species (ROS) accumulation and associated inflammatory responses. Visceral adiposity is a central component of the metabolic syndrome and it is also strongly associated with insulin resistance. Both visceral obesity and insulin resistance are important risk factors for the development of type 2 diabetes. In the development of insulin resistance, it is likely that intra-abdominal adipose tissue plays a critical role in a complex endocrine and neural network involving several tissues. This review paper focuses on neuroendocrine 'stress' factors that target insulin-responsive tissues, in particular adipose tissue. We propose that there are common pathways by which dysregulation in different endocrine systems may contribute to the development of type 2 diabetes. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
C1 [Sjostrand, Mikaela; Eriksson, Jan W.] Sahlgrens Univ Hosp, Lundberg Lab Diabet Res, Dept Med, SE-41345 Gothenburg, Sweden.
   [Sjostrand, Mikaela; Eriksson, Jan W.] AstraZeneca R&D, Molndal, Sweden.
C3 Sahlgrenska University Hospital; AstraZeneca
RP Eriksson, JW (corresponding author), Sahlgrens Univ Hosp, Lundberg Lab Diabet Res, Dept Med, SE-41345 Gothenburg, Sweden.
EM jan.eriksson@medic.gu.se
RI Eriksson, Jan/AAB-5820-2021
FU Swedish Research Council [14287]; Swedish Diabetes Association;
   AstraZeneca RD
FX This work has been supported by the Swedish Research Council (Medicine,
   14287), the Swedish Diabetes Association and AstraZeneca R&D. The
   scientific contributions and advice from Jonas Buren, Magdalena
   Lundgren, Frida Renstrom, Stina Lindmark, Per-Anders Jansson and Maria
   Svensson are gratefully acknowledged.
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NR 92
TC 24
Z9 28
U1 0
U2 8
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0303-7207
J9 MOL CELL ENDOCRINOL
JI Mol. Cell. Endocrinol.
PD JAN 15
PY 2009
VL 297
IS 1-2
SI SI
BP 104
EP 111
DI 10.1016/j.mce.2008.05.010
PG 8
WC Cell Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Endocrinology & Metabolism
GA 396OI
UT WOS:000262600600013
PM 18599191
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Moraes, JB
   Maes, M
   Barbosa, DS
   Ferrari, TZ
   Uehara, MKS
   Carvalho, AF
   Nunes, SOV
AF Moraes, Juliana Brum
   Maes, Michael
   Barbosa, Decio Sabbatini
   Ferrari, Thais Zagabria
   Spagolla Uehara, Marcela Keikko
   Carvalho, Andre F.
   Vargas Nunes, Sandra Odebrecht
TI Elevated C-reactive Protein Levels in Women with Bipolar Disorder may be
   Explained by a History of Childhood Trauma, Especially Sexual Abuse,
   Body Mass Index and Age
SO CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
LA English
DT Article
DE Bipolar disorder; childhood sexual abuse; C-reactive protein;
   depression; early life stress; immune activation; inflammation
ID ACUTE-PHASE PROTEINS; MAJOR DEPRESSION; METABOLIC SYNDROME; STRESS;
   MALTREATMENT; PREVALENCE; SCHIZOPHRENIA; INFLAMMATION; METAANALYSIS;
   COMORBIDITY
AB Objective and Background: To evaluate whether increased levels of high-sensitivity C-reactive protein (hs-CRP) observed in individuals with bipolar disorder (BD) compared to healthy controls (HCs) could be influenced by a previous exposure to early life stress (ELS) independently from other explanatory or background variables, including age, body mass index (BMI), and the presence of co-occurring mental disorders.
   Method: In this case-control study, we included 142 healthy controls and 92 bipolar I and II patients. The Childhood Trauma Questionnaire was administered in a subset of 30 female patients with BD and 31 female HCs, and plasma hs-CRP was measured in all subjects. Multivariable models adjusted the data for the possible confounding variables.
   Results: Serum hs-CRP levels were significantly higher in patients with BD compared to HCs. However, after controlling for BMI, these differences were no longer significant. Around 55% of the variance in hs-CRP was explained by cumulative and independent effects of age, BMI and childhood trauma, especially sexual abuse.
   Conclusion: Our results show that increased hs-CRP levels in BD patients are more related to childhood trauma, especially sexual abuse, age and BMI than to a diagnosis of BD per se. These data suggest that peripheral inflammation may underpin the well-known detrimental effects of childhood maltreatment and obesity in the course of BD. Hs-CRP data are difficult to interpret if they are not adjusted for effects of BMI and age.
C1 [Moraes, Juliana Brum; Maes, Michael; Barbosa, Decio Sabbatini; Ferrari, Thais Zagabria; Spagolla Uehara, Marcela Keikko; Vargas Nunes, Sandra Odebrecht] Univ Estadual Londrina, Hlth Sci Grad Program, Hlth Sci Ctr, Av Robert Koch 60, BR-86035380 Londrina, Parana, Brazil.
   [Moraes, Juliana Brum] Chulalongkorn Univ, Fac Med, Dept Psychiat, Bangkok, Thailand.
   [Maes, Michael] Med Univ Plovdiv, Dept Psychiat, Plovdiv, Bulgaria.
   [Maes, Michael] Deakin Univ, Sch Med, IMPACT Strateg Res Ctr, POB 281, Geelong, Vic 3220, Australia.
   [Barbosa, Decio Sabbatini; Vargas Nunes, Sandra Odebrecht] Univ Estadual Londrina, Dept Clin & Toxicol Anal, Londrina, Brazil.
   [Carvalho, Andre F.] Univ Fed Ceara, Fac Med, Dept Clin Med, Fortaleza, CE, Brazil.
   [Carvalho, Andre F.] Univ Fed Ceara, Fac Med, Translat Psychiat Res Grp, Fortaleza, CE, Brazil.
C3 Universidade Estadual de Londrina; Chulalongkorn University; Medical
   University Plovdiv; Deakin University; Universidade Estadual de
   Londrina; Universidade Federal do Ceara; Universidade Federal do Ceara
RP Maes, M (corresponding author), Deakin Univ, Sch Med, IMPACT Strateg Res Ctr, POB 281, Geelong, Vic 3220, Australia.
EM dr.michaelmaes@hotmail.com
RI Nunes, Sandra/B-4035-2019; Brum Moraes, Juliana/AAC-9950-2022; Maes,
   Michael/B-8546-2011; Carvalho, Andre/AEZ-4001-2022; Barbosa,
   Décio/AAE-6351-2019
OI Maes, Michael/0000-0002-2012-871X; Brum Moraes,
   Juliana/0000-0002-3380-5900
FU Ministry for Science and Technology of Brazil (CNPq) [470344/2013-0,
   465928/2014-5]
FX This work was supported by the Ministry for Science and Technology of
   Brazil (CNPq) (grant numbers: 470344/2013-0 and 465928/2014-5). The
   authors would like to acknowledge gratefully the Health Sciences
   Postgraduate Program at the State University of Londrina, Brazil.
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NR 46
TC 29
Z9 31
U1 0
U2 7
PU BENTHAM SCIENCE PUBL
PI BUSUM
PA PO BOX 294, BUSUM, 1400 AG, NETHERLANDS
SN 1871-5273
EI 1996-3181
J9 CNS NEUROL DISORD-DR
JI CNS Neurol. Disord.-Drug Targets
PY 2017
VL 16
IS 4
BP 514
EP 521
DI 10.2174/1871527316666170407151514
PG 8
WC Neurosciences; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Pharmacology & Pharmacy
GA FA3CL
UT WOS:000405318900015
PM 28403800
DA 2025-06-11
ER

PT J
AU Boehncke, WH
   Buerger, C
   Boehncke, S
AF Boehncke, W. -H.
   Buerger, C.
   Boehncke, S.
TI Co-morbidities in psoriasis vulgaris
SO HAUTARZT
LA English
DT Article
DE Metabolic syndrome; Insulin resistence; Endothelial dysfunction; Tumor
   nekrosis factor alpha; Thrombocytes
ID NURSES HEALTH; RISK; COMORBIDITIES; INFLAMMATION; DISEASES; SMOKING;
   PROTEIN; EVENTS; WOMEN; IL23R
AB Epidemiologic data document not only a higher prevalence of joint involvement among psoriasis patients than previously thought, but also an association with numerous other diseases, including depression, smoking, alcoholism, Crohn's disease, and metabolic syndrome. The resulting increased cardiovascular mortality is of particular clinical importance, and its pathogenetic link as a complication of the psoriatic inflammation is well recognized. Thus, we need to re-invent the management of psoriasis: Dermatologists are not only the sentinel regarding the early diagnosis of psoriatic arthritis, but also of metabolic complications such as dyslipidemia or diabetes. Moreover, they need to keep in mind interactions between (systemic) anti-psoriatic drugs and the co-medication of their patients as well as possible consequences of these co-medications on the course of psoriasis. To successfully accomplish this mission, a comprehensive management concept and ground-breaking research are urgently needed.
C1 [Boehncke, W. -H.; Buerger, C.] Univ Frankfurt Klinikum, Zentrum Dermatol & Venerol, D-60590 Frankfurt, Germany.
   [Boehncke, S.] Univ Frankfurt Klinikum, Med Klin 1, D-60590 Frankfurt, Germany.
C3 Goethe University Frankfurt; Goethe University Frankfurt Hospital;
   Goethe University Frankfurt; Goethe University Frankfurt Hospital
RP Boehncke, WH (corresponding author), Univ Frankfurt Klinikum, Zentrum Dermatol & Venerol, Theodor Stern Kai 7, D-60590 Frankfurt, Germany.
EM Boehncke@em.uni-frankfurt.de
RI Buerger, Claudia/AAE-4685-2019; Buerger, Claudia/JMO-3516-2023
OI Buerger, Claudia/0000-0002-7838-197X; Boehncke,
   Wolf-Henning/0000-0002-1225-7124
CR Anderson HDI, 2004, J BIOL CHEM, V279, P963, DOI 10.1074/jbc.M309552200
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NR 30
TC 16
Z9 16
U1 0
U2 3
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0017-8470
EI 1432-1173
J9 HAUTARZT
JI Hautarzt
PD FEB
PY 2009
VL 60
IS 2
BP 116
EP 121
DI 10.1007/s00105-008-1663-3
PG 6
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 409YF
UT WOS:000263541000011
PM 19151962
DA 2025-06-11
ER

PT J
AU Silva, AMDE
   Pereira, RO
   Oliveira, AKD
   Harris, FS
   de Melo, ILP
   Almeida-Souza, TH
   Yoshime, LT
   Melo, CD
   dos Santos, JL
   de Andrade-Wartha, ERS
   Cogliati, B
   Granato, D
   Mancini, J
AF de Oliveira e Silva, Ana Mara
   Pereira, Raquel Oliveira
   Oliveira, Anne Karoline de Souza
   Harris, Fernanda Santana
   de Melo, Illana Louise Pereira
   Almeida-Souza, Thiago Henrique
   Yoshime, Luciana Tedesco
   Melo, Caroline dos Santos
   dos Santos, Jymmys Lopes
   de Andrade-Wartha, Elma Regina Silva
   Cogliati, Bruno
   Granato, Daniel
   Mancini-Filho, Jorge
TI Ameliorative effects of aqueous extract from rosemary on oxidative
   stress and inflammation pathways caused by a high-fat diet in C57BL/6
   mice
SO APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
LA English
DT Article; Early Access
DE obesity; metabolic syndrome; rosemary; phenolic compounds; oxidative
   stress; inflammation
ID ROSMARINUS-OFFICINALIS L.; CARNOSIC ACID; ADIPOCYTE DIFFERENTIATION;
   ANTIOXIDANT ACTIVITY; METABOLIC SYNDROME; LIPID-METABOLISM;
   ACCUMULATION; ACTIVATION; STEATOSIS; TISSUES
AB Rosemary is an herb exhibits biological properties, attenuates inflammation, oxidative stress, and improves lipid profile. Here, we evaluated the effects of rosemary aqueous extract (RE) on mice fed with a high-fat diet (HFD). Male C57BL/6 mice were administered a control diet or HFD for 10 weeks. The treated groups received RE in the diet at different concentrations: 25, 250, and 500 mg/100 g. After 10 weeks, serum concentrations of glucose, lipid, insulin, leptin, adiponectin, and cytokines were evaluated and the oxygen radical absorbance capacity was determined. Histological analysis was performed to determine the concentrations of triacylglycerides (TG), total cholesterol, cytokines, and antioxidant enzymes as well as the expression of genes involved in lipid metabolism, oxidative stress, and inflammation. The dietary RE ameliorated HFD-induced weight gain, adipose tissue weight, glucose intolerance, and insulin, leptin, and free fatty acid levels. Reduction in hepatic TG deposition was observed. The levels of inflammatory cytokines decreased, and the expression of genes involved in lipid metabolism increased. RE mitigated oxidative stress and reduced the production of reactive oxygen species in HepG2 and 3T3-L1 cells. Therefore, RE is a potential therapeutic agent for the prevention of inflammation and oxidative stress outcomes associated with obesity.
C1 [de Oliveira e Silva, Ana Mara; Almeida-Souza, Thiago Henrique; Melo, Caroline dos Santos; de Andrade-Wartha, Elma Regina Silva] Fed Univ Sergipe UFS, Nutr Sci Grad Program, Sao Cristovao, Sergipe, Brazil.
   [de Oliveira e Silva, Ana Mara; Pereira, Raquel Oliveira; Oliveira, Anne Karoline de Souza] Fed Univ Sergipe UFS, Hlth Sci Grad Program, Aracaju, Sergipe, Brazil.
   [Harris, Fernanda Santana; de Melo, Illana Louise Pereira; Yoshime, Luciana Tedesco; Mancini-Filho, Jorge] Univ Sao Paulo, Fac Pharmaceut Sci, Dept Food & Expt Nutr, Lab Lipids, Sao Paulo, SP, Brazil.
   [dos Santos, Jymmys Lopes] Fed Univ Sergipe UFS, Dept Morphol, Sao Cristovao, Sergipe, Brazil.
   [Cogliati, Bruno] Univ Sao Paulo, Sch Vet Med & Anim Sci, Dept Pathol, Sao Paulo, SP, Brazil.
   [Granato, Daniel] Univ Limerick, Fac Sci & Engn, Dept Biol Sci, Limerick V94 T9PX, Ireland.
C3 Universidade de Sao Paulo; Universidade de Sao Paulo; University of
   Limerick
RP Silva, AMDE (corresponding author), Fed Univ Sergipe UFS, Nutr Sci Grad Program, Sao Cristovao, Sergipe, Brazil.; Silva, AMDE (corresponding author), Fed Univ Sergipe UFS, Hlth Sci Grad Program, Aracaju, Sergipe, Brazil.
EM anamaraufs@gmail.com
RI Melo, Caroline/KIJ-1794-2024; Granato, Daniel/AAC-6151-2019; Yoshime,
   Luciana/L-5705-2015; Cogliati, Bruno/E-9956-2012
OI Granato, Daniel/0000-0002-4533-1597; Almeida-Souza, Thiago
   Henrique/0000-0001-8977-9337; Silva, Ana/0000-0003-0831-8833
FU National Council of Tech-nological and Scientific Development (CNPq,
   Brazil) [487122/2013-5]; National Council for the Improvement of Higher
   Education (CAPES, Brazil)
FX Acknowledgements The authors would like to thank the National Council of
   Tech-nological and Scientific Development (CNPq, Brazil) for fund-ing
   this project (grant number 487122/2013-5) . This research also was
   supported by grants from National Council for the Improvement of Higher
   Education (CAPES, Brazil) .
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NR 66
TC 3
Z9 3
U1 1
U2 15
PU CANADIAN SCIENCE PUBLISHING
PI OTTAWA
PA 65 AURIGA DR, SUITE 203, OTTAWA, ON K2E 7W6, CANADA
SN 1715-5312
EI 1715-5320
J9 APPL PHYSIOL NUTR ME
JI Appl. Physiol. Nutr. Metab.
PD 2024 JAN 9
PY 2024
DI 10.1139/apnm-2023-0157
EA JAN 2024
PG 14
WC Nutrition & Dietetics; Physiology; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics; Physiology; Sport Sciences
GA EW1S2
UT WOS:001141883800001
PM 38048548
DA 2025-06-11
ER

PT J
AU Bansal, C
   Jain, R
   Shukla, U
   Paul, S
AF Bansal, Charu
   Jain, Rachna
   Shukla, Umesh
   Paul, Smita
TI Emotional Stress Consequences in the Development of Type 2 Diabetes
   Mellitus and Solutions
SO INTERNATIONAL JOURNAL OF AYURVEDIC MEDICINE
LA English
DT Review
DE Type 2 Diabetes mellitus; Stress; Diabetes risk factors; Emotional
   stress impact
ID ANTIDEPRESSANT-LIKE ACTIVITY; CONVOLVULUS-PLURICAULIS;
   PSYCHOLOGICAL-FACTORS; DEPRESSIVE SYMPTOMS; METABOLIC SYNDROME;
   CENTELLA-ASIATICA; ESSENTIAL OIL; RISK-FACTORS; LIFE EVENTS; HOSTILITY
AB India is recognized as diabetic capital of the world now and among all chronic diseases increased prevalence of Type 2 Diabetes mellitus has been recognized globally. Though various modifiable risk factors are identified for the development of type 2 diabetes mellitus such as prediabetes, overweight, obesity, poor diet, smoking, physical inactivity and given importance in the management of disease. But among all stress and anxiety has not been getting proper importance in development and management of Type 2 diabetes. Though number of studies have been identified stress as risk factor for type 2 diabetes. Thus, the present write up is aimed to review the effect of different emotional stressor as risk in the development and uncontrolled hyperglycemia in type 2 diabetes mellitus patients with effective solutions. Material and Methods: This review is based on data collected from classical Ayurvedic literature, and published research works in various journals. Observations and Results: cited based on research reviews to find out risk odds of different emotional stressor and type 2 diabetes with solutions based on Ayurveda and Yoga principles such as role of Raga therapy, Yogasan, Pranayama (breathing technique), Panchakarma procedures and use of Medhya Rasayana (nootropic) drugs. Conclusion: Counselling would be one of the best strategy to create awareness among healthy individual and type 2 diabetic to opt healthy behaviour to manage emotional stress and for the prevention and better control of type 2 diabetes mellitus. Thus, Present write up is an effort to provide attention on various emotional stressor as risk factor and also discuss the various healthy behavioural techniques to control emotional stress.
C1 [Bansal, Charu] Pt Khushilal Sharma Govt Ayurveda Coll & Inst, Dept Swasthavritta & Yoga, Bhopal, MP, India.
   [Shukla, Umesh] Pt Khushilal Sharma Govt Ayurveda Coll & Inst, Dept Panchakarma, Bhopal, MP, India.
   [Jain, Rachna] Rani Dullaiya Mem Ayurveda PG Coll & Hosp, Dept Swasthavritta & Yoga, Bhopal, India.
   [Paul, Smita] Rani Dullaiya Mem Ayurveda PG Coll & Hosp, Dept Roga Nidan Evam Vikriti Vigyan, Bhopal, India.
RP Bansal, C (corresponding author), Pt Khushilal Sharma Govt Ayurveda Coll & Inst, Dept Swasthavritta, Bhopal 462042, Madhya Pradesh, India.
EM bansalcharu73@rediffmail.com
RI Bansal, Dr Charu/HBC-5791-2022
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NR 49
TC 0
Z9 0
U1 1
U2 12
PU AYURVEDA SAHITI PRABHA
PI ANDHRA PRADESH
PA 1-2-288-23, SBH COLONY, HYDERABAD, ANDHRA PRADESH, 500 029, INDIA
SN 0976-5921
J9 INT J AYURVEDIC MED
JI Int. J. Ayurvedic Med.
PD JAN-MAR
PY 2021
VL 12
IS 1
BP 7
EP 13
PG 7
WC Medicine, Research & Experimental
WE Emerging Sources Citation Index (ESCI)
SC Research & Experimental Medicine
GA RI6NA
UT WOS:000637022500002
DA 2025-06-11
ER

PT J
AU Benade, J
   Sher, L
   De Klerk, S
   Deshpande, G
   Bester, D
   Marnewick, JL
   Sieck, G
   Laher, I
   Essop, MF
AF Benade, Janina
   Sher, Lucien
   De Klerk, Sheneez
   Deshpande, Gaurang
   Bester, Dirk
   Marnewick, Jeanine L.
   Sieck, Gary
   Laher, Ismail
   Essop, M. Faadiel
TI The Impact of Sugar-Sweetened Beverage Consumption on the Liver: A
   Proteomics-Based Analysis
SO ANTIOXIDANTS
LA English
DT Article
DE sugar-sweetened beverages; metabolic syndrome; endoplasmic reticulum
   stress; mitochondrial dysfunction; mitochondrial fission and fusion;
   antioxidant capacity; calcium homeostasis
ID ENDOPLASMIC-RETICULUM STRESS; HIGH-FAT DIET; INSULIN-RESISTANCE;
   MITOCHONDRIAL DYSFUNCTION; MITOFUSIN 2; ER STRESS; DOSE-RESPONSE;
   CELL-DEATH; MECHANISM; DYNAMICS
AB Cardiometabolic complications such as the metabolic syndrome and Type 2 Diabetes Mellitus (T2DM) are major causes of global morbidity and mortality. As sugar-sweetened beverages (SSBs) are implicated in this process, this study aimed to obtain greater mechanistic insights. Male Wistar rats (similar to 200 g) were gavaged with a local SSB every day for a period of six months while the control group was gavaged with an iso-volumetric amount of water. Experimental dosages were calculated according to the surface area-to-volume ratio and were equivalent to 125 mL/day (in human terms). A proteomic analysis was performed on isolated liver samples and thereafter, markers of endoplasmic reticulum (ER) stress, antioxidant/oxidant capacity, calcium regulation, and mitochondrial functionality were assessed. These data show that SSB consumption resulted in (a) the induction of mild hepatic ER stress; (b) altered hepatic mitochondrial dynamics; and (c) perturbed calcium handling across mitochondria-associated ER membranes. Despite significant changes in markers of ER stress, the antioxidant response and calcium handling (proteomics data), the liver is able to initiate adaptive responses to counteract such stressors. However, the mitochondrial data showed increased fission and decreased fusion that may put the organism at risk for developing insulin resistance and T2DM in the longer term.
C1 [Benade, Janina; Sher, Lucien; De Klerk, Sheneez; Deshpande, Gaurang; Laher, Ismail; Essop, M. Faadiel] Stellenbosch Univ, Ctr Cardiometab Res Africa CARMA, Dept Physiol Sci, ZA-7600 Stellenbosch, South Africa.
   [Bester, Dirk; Marnewick, Jeanine L.] Cape Peninsula Univ Technol, Appl Microbial & Hlth Biotechnol Inst, ZA-7535 Cape Town, South Africa.
   [Bester, Dirk] Cape Peninsula Univ Technol, Fac Hlth & Wellness Sci, ZA-7535 Cape Town, South Africa.
   [Sieck, Gary] Mayo Clin, Dept Physiol & Biomed Engn, Rochester, MN 55905 USA.
   [Laher, Ismail] Univ British Columbia, Dept Anesthesiol Pharmacol & Therapeut, Vancouver, BC V6T 1Z3, Canada.
C3 Stellenbosch University; Cape Peninsula University of Technology; Cape
   Peninsula University of Technology; Mayo Clinic; University of British
   Columbia
RP Essop, MF (corresponding author), Stellenbosch Univ, Ctr Cardiometab Res Africa CARMA, Dept Physiol Sci, ZA-7600 Stellenbosch, South Africa.
EM janinabenade@gmail.com; 18718078@sun.ac.za; sheodk@gmail.com;
   gaurang1712@gmail.com; besterd@cput.ac.za; MarnewickJ@cputac.za;
   sieck.gary@mayo.edu; ismail.laher@ubc.ca; mfessop@sun.ac.za
RI TECHNOLOGY, CAPE PENINSULA UNIVERSITY/L-3761-2019; Laher,
   Ismail/X-3323-2019; Bester, Dirk/ABB-6544-2021
OI Essop, Faadiel/0000-0002-8434-4294; Laher, Ismail/0000-0002-3917-4417;
   Bester, Dirk/0000-0002-5871-1011
FU South African National Research Foundation [IFR150119112480];
   Stellenbosch University
FX This study was funded by grants from the South African National Research
   Foundation (IFR150119112480) and Stellenbosch University (to MFE).
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NR 60
TC 5
Z9 5
U1 0
U2 3
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD JUL
PY 2020
VL 9
IS 7
AR 569
DI 10.3390/antiox9070569
PG 17
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA MW2DC
UT WOS:000556853400001
PM 32630236
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Sautin, YY
   Nakagawa, T
   Zharikov, S
   Johnson, RJ
AF Sautin, Yuri Y.
   Nakagawa, Takahiko
   Zharikov, Sergey
   Johnson, Richard J.
TI Adverse effects of the classic antioxidant uric acid in adipocytes:
   NADPH oxidase-mediated oxidative/nitrosative stress
SO AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
LA English
DT Article
DE redox signaling; nitric oxide; reactive oxygen species
ID MUSCLE-CELL-PROLIFERATION; LOW-DENSITY-LIPOPROTEIN; MAP KINASE
   ACTIVATION; SMOOTH-MUSCLE; METABOLIC SYNDROME; NITRIC-OXIDE; OXIDATIVE
   STRESS; NAD(P)H OXIDASE; REACTIVE OXYGEN; ENDOTHELIAL DYSFUNCTION
AB Uric acid is considered a major antioxidant in human blood that may protect against aging and oxidative stress. Despite its proposed protective properties, elevated levels of uric acid are commonly associated with increased risk for cardiovascular disease and mortality. Furthermore, recent experimental studies suggest that uric acid may have a causal role in hypertension and metabolic syndrome. All these conditions are thought to be mediated by oxidative stress. In this study we demonstrate that differentiation of cultured mouse adipocytes is associated with increased production of reactive oxygen species (ROS) and uptake of uric acid. Soluble uric acid stimulated an increase in NADPH oxidase activity and ROS production in mature adipocytes but not in preadipocytes. The stimulation of NADPH oxidase-dependent ROS by uric acid resulted in activation of MAP kinases p38 and ERK1/2, a decrease in nitric oxide bioavailability, and an increase in protein nitrosylation and lipid oxidation. Collectively, our results suggest that hyperuricemia induces redox-dependent signaling and oxidative stress in adipocytes. Since oxidative stress in the adipose tissue has recently been recognized as a major cause of insulin resistance and cardiovascular disease, hyperuricemia-induced alterations in oxidative homeostasis in the adipose tissue might play an important role in these derangements.
C1 Univ Florida, Dept Med, Div Nephrol Hypertens & Transplantat, Gainesville, FL 32610 USA.
C3 State University System of Florida; University of Florida
RP Sautin, YY (corresponding author), Univ Florida, Dept Med, Div Nephrol Hypertens & Transplantat, POB 100224, Gainesville, FL 32610 USA.
EM sautiyy@medicine.ufl.edu
RI Zharikov, Sergey/G-1636-2011
OI Sautin, Yuri/0000-0003-3618-5134
FU NHLBI NIH HHS [HL68607] Funding Source: Medline; NIDDK NIH HHS [DK52121]
   Funding Source: Medline
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NR 58
TC 609
Z9 666
U1 2
U2 41
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0363-6143
J9 AM J PHYSIOL-CELL PH
JI Am. J. Physiol.-Cell Physiol.
PD AUG
PY 2007
VL 293
IS 2
BP C584
EP C596
DI 10.1152/ajpcell.00600.2006
PG 13
WC Cell Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Physiology
GA 197UC
UT WOS:000248581000009
PM 17428837
DA 2025-06-11
ER

PT J
AU Courties, A
   Gualillo, O
   Berenbaum, F
   Sellam, J
AF Courties, A.
   Gualillo, O.
   Berenbaum, F.
   Sellam, J.
TI Metabolic stress-induced joint inflammation and osteoarthritis
SO OSTEOARTHRITIS AND CARTILAGE
LA English
DT Article
DE Osteoarthritis; Inflammation; Metabolic syndrome; Obesity; Adipokines;
   Oxidative stress
ID GLYCATION END-PRODUCTS; BODY-MASS INDEX; ENDOPLASMIC-RETICULUM STRESS;
   CARDIOVASCULAR-DISEASE RISK; HUMAN ARTICULAR-CARTILAGE; TYPE-2 DIABETES
   RISK; NF-KAPPA-B; KNEE OSTEOARTHRITIS; HAND OSTEOARTHRITIS; WAIST
   CIRCUMFERENCE
AB Osteoarthritis (OA) is a heterogeneous disorder with several risk factors. Among them, obesity has a major impact on both loading and non-loading joints. Mechanical overload and activity of systemic inflammatory mediators derived from adipose tissue (adipokines, free fatty acids (FFA), reactive oxygen species (ROS)) provide clues to the increased incidence and prevalence of OA in obesity. Recently, research found greater OA prevalence and incidence in obese patients with cardiometabolic disturbances than "healthy" obese patients, which led to the description of a new OA phenotype - metabolic syndrome (MetS)-associated OA. Indeed, individual metabolic factors (diabetes, dyslipidemia, and hypertension) may increase the risk of obesity-induced OA. This review discusses hypotheses based on pathways specific to a metabolic factor in MetS-associated OA, such as the role of advanced glycation end products (AGEs) and glucose toxicity. A better understanding of these phenotypes based on risk factors will be critical for designing trials of this specific subset of OA. (C) 2015 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.
C1 [Courties, A.; Berenbaum, F.; Sellam, J.] Univ Paris 06, St Antoine Hosp, AP HP, Rheumatol Dept,Inserm,UMR S 938,DHU i2B, Paris, France.
   [Gualillo, O.] Univ Santiago, Clin Hosp, SERGAS Serv Galego Saude, Santiago De Compostela, Spain.
   [Gualillo, O.] Univ Santiago, Clin Hosp, IDIS Inst Invest Sainitaria Santiago,Res Lab 9, NEIRID Lab Neuroendocrine Interact Rheumatol & In, Santiago De Compostela, Spain.
C3 Institut National de la Sante et de la Recherche Medicale (Inserm);
   Sorbonne Universite; Assistance Publique Hopitaux Paris (APHP); Hopital
   Universitaire Saint-Antoine - APHP; Universidade de Santiago de
   Compostela; Complexo Hospitalario Universitario de Santiago de
   Compostela; Universidade de Santiago de Compostela; Complexo
   Hospitalario Universitario de Santiago de Compostela
RP Berenbaum, F (corresponding author), Hop St Antoine, AP HP, Serv Rhumatol, 184 Rue Faubourg, F-75012 Paris, France.
EM francis.berenbaum@sat.aphp.fr
RI Berenbaum, Francis/AAO-5690-2020; GUALILLO, ORESTE/B-8223-2008
OI berenbaum, francis/0000-0001-8252-7815; GUALILLO,
   ORESTE/0000-0002-7154-1328
FU Fondation Arthritis Jacques Courtin (ROAD network); Instituto de Salud
   Carlos III [PI11/01073, PI14/00016]
FX AC, FB and JS are supported by Fondation Arthritis Jacques Courtin (ROAD
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   research-staff stabilization contract (ISCIII/SERGAS). Oreste Gualillo
   is supported by Instituto de Salud Carlos III (PI11/01073 and
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   Red de Investigacion en Inflamacion y Enfermedades Reumaticas) via
   Instituto de Salud Carlos III (ISCIII).
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NR 144
TC 170
Z9 189
U1 0
U2 41
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1063-4584
EI 1522-9653
J9 OSTEOARTHR CARTILAGE
JI Osteoarthritis Cartilage
PD NOV
PY 2015
VL 23
IS 11
BP 1955
EP 1965
DI 10.1016/j.joca.2015.05.016
PG 11
WC Orthopedics; Rheumatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Orthopedics; Rheumatology
GA CV0LB
UT WOS:000363941100018
PM 26033164
OA Green Accepted, Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Battelli, MG
   Polito, L
   Bolognesi, A
AF Battelli, Maria Giulia
   Polito, Letizia
   Bolognesi, Andrea
TI Xanthine oxidoreductase in atherosclerosis pathogenesis: Not only
   oxidative stress
SO ATHEROSCLEROSIS
LA English
DT Review
DE Atherosclerosis; Cardiovascular diseases; Metabolic syndrome; Oxidative
   stress; Uric acid; Xanthine oxidoreductase
ID OXIDASE INHIBITOR FEBUXOSTAT; FREE-RADICAL PRODUCTION; URIC-ACID;
   ENDOTHELIAL DYSFUNCTION; NAD(P)H OXIDASE; CARDIOVASCULAR-DISEASE;
   HYPERTENSION; HYPERURICEMIA; DEHYDROGENASE; PROTECTION
AB Endothelial xanthine oxidoreductase (XOR) together with NAD(P) H oxidase and nitric oxide (NO) synthase plays a physiologic role in inflammatory signalling, the regulation of NO production and vascular function. The oxidative stress generated by these enzymes may induce endothelial dysfunction, leading to atherosclerosis, cardiovascular diseases and metabolic syndrome. XOR activity creates both oxidant and anti-oxidant products that are implicated in the development of hypertension, smoking vascular injury, dyslipidemia and diabetes, which are the main risk factors of atherosclerosis. In particular, uric acid may have a protective as well as a detrimental role in vascular alterations, thus justifying the multidirectional effects of XOR inhibition. Moreover, XOR products are associated with cell differentiation, leading to adipogenesis and foam cell formation, as well as to the production of monocyte chemoattractant protein-1 from arterial smooth muscle cells, after proliferation and migration. The role of XOR in adipogenesis is also connected with insulin resistance and obesity, two main features of type 2 diabetes. (C) 2014 The Authors. Published by Elsevier Ireland Ltd.
C1 [Battelli, Maria Giulia; Polito, Letizia; Bolognesi, Andrea] Alma Mater Studiorum Univ Bologna, Dept Expt Diagnost & Specialty Med DIMES, Gen Pathol Unit, I-40126 Bologna, Italy.
C3 University of Bologna
RP Polito, L (corresponding author), Alma Mater Studiorum Univ Bologna, Dept Expt Diagnost & Specialty Med DIMES, Gen Pathol Unit, Via S Giacomo 14, I-40126 Bologna, Italy.
EM mariagiulia.battelli@unibo.it; letizia.polito@unibo.it;
   andrea.bolognesi@unibo.it
RI Bolognesi, Andrea/Q-6526-2017; Battelli, Maria Giulia/G-2711-2015;
   Polito, Letizia/H-2877-2019
OI Battelli, Maria Giulia/0000-0001-6048-0454; Polito,
   Letizia/0000-0001-8051-4981; Bolognesi, Andrea/0000-0001-7497-4586
FU Alma Mater Studiorum - University of Bologna (RFO); Pallotti Legacies
   for Cancer Research
FX This work was supported by funds for selected research topics from the
   Alma Mater Studiorum - University of Bologna (RFO) and by the Pallotti
   Legacies for Cancer Research.
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NR 58
TC 136
Z9 142
U1 1
U2 30
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0021-9150
EI 1879-1484
J9 ATHEROSCLEROSIS
JI Atherosclerosis
PD DEC
PY 2014
VL 237
IS 2
BP 562
EP 567
DI 10.1016/j.atherosclerosis.2014.10.006
PG 6
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA AW1RG
UT WOS:000346066600058
PM 25463089
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Meiliana, A
   Dewi, NM
   Wijaya, A
AF Meiliana, Anna
   Dewi, Nurrani Mustika
   Wijaya, Andi
TI Hypothalamic Microinflammation: New Paradigm In Obesity And Metabolic
   Disease
SO INDONESIAN BIOMEDICAL JOURNAL
LA English
DT Review
DE hypothalamus; inflammation; metabolism; obesity; metabolic syndrome
ID ENDOPLASMIC-RETICULUM STRESS; NF-KAPPA-B; MITOCHONDRIA-ASSOCIATED
   MEMBRANES; CONNECTS ER STRESS; NEURAL STEM-CELLS; INSULIN-RESISTANCE;
   LEPTIN RESISTANCE; FOOD-INTAKE; ENERGY-BALANCE; ADIPOSE-TISSUE
AB BACKGROUND: Hypothalamus is the master regulator of body's systemic homeostasis including energy balance, body temperature, sleep, blood pressure, and circadian rhythms. This review article will highlight the shifting of the old paradigm of obesity-inflammation-metabolic syndrome, which was focused on visceral organs and systemic inflammation, into a new model involving microinflammation in the master regulator of endocrine system, i.e., hypothalamus.
   CONTENT: Since the early stage of over-nutritional conditions and aging process, microinflammation in hypothalamus has started to emerge, due to the activation of several proinflammatory signaling pathways, especially the nuclear factor kappa B (NF-kappa B) and c-Jun N-terminal kinase (JNK)-mediated nuclear transcriptional programs. Together with intracellular organelle stress signals, these pathways develop a chronic microinflammatory environment in the hypothalamus leading to obesity and metabolic disorders.
   SUMMARY: Hypothalamic inflammation has been noted not only as an important driver of impaired energy balance, but also contribute in altered neurocircuit functions and promote obesity-associated metabolic impairment.
C1 [Meiliana, Anna; Wijaya, Andi] Padjadjaran State Univ, Postgrad Program Clin Pharm, Jl Eijkman 38, Bandung, Indonesia.
   [Meiliana, Anna; Dewi, Nurrani Mustika; Wijaya, Andi] Prodia Clin Lab, Jl Cisangkuy 2, Bandung, Indonesia.
C3 Universitas Padjadjaran; Clinical Laboratory Prodia
RP Meiliana, A (corresponding author), Padjadjaran State Univ, Postgrad Program Clin Pharm, Jl Eijkman 38, Bandung, Indonesia.; Meiliana, A (corresponding author), Prodia Clin Lab, Jl Cisangkuy 2, Bandung, Indonesia.
EM anna.meiliana@prodia.co.id
RI Meiliana, Anna/ABC-9368-2020
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NR 166
TC 1
Z9 1
U1 0
U2 4
PU PRODIA EDUCATION & RESEARCH INST
PI JAKARTA
PA PRODIA TOWER 8TH FLR, JL KRAMAT RAYA NO 150, JAKARTA, 00000, INDONESIA
SN 2355-9179
J9 INDONES BIOMED J
JI Indones. Biomed. J.
PD SEP
PY 2020
VL 12
IS 3
BP 201
EP 213
DI 10.18585/inabj.v12i3.1235
PG 13
WC Medicine, Research & Experimental
WE Emerging Sources Citation Index (ESCI)
SC Research & Experimental Medicine
GA NK5IN
UT WOS:000566765100002
OA gold
DA 2025-06-11
ER

PT J
AU Pyykkönen, AJ
   Räikkönen, K
   Tuomi, T
   Eriksson, JG
   Groop, L
   Isomaa, B
AF Pyykkonen, Antti-Jussi
   Raikkonen, Katri
   Tuomi, Tiinamaija
   Eriksson, Johan G.
   Groop, Leif
   Isomaa, Bo
TI Association between depressive symptoms and metabolic syndrome is not
   explained by antidepressant medication: Results from the PPP-Botnia
   Study
SO ANNALS OF MEDICINE
LA English
DT Article
DE Antidepressive agents; depression; metabolic syndrome
ID STRESSFUL LIFE EVENTS; DIABETES-MELLITUS; RISK; WOMEN; PREVENTION;
   HEALTH; CONSULTATION; DEFINITIONS; ADULTS; MOOD
AB Introduction. To study whether the frequently reported association between depressive symptoms and the metabolic syndrome (MetS) and its individual components are secondary to the use of antidepressant medication and to established diabetes or cardiovascular diseases (CVD).
   Patients and methods. A population-based, random sample of 4,967 women and men aged 18-75 years. MetS was defined according to the new, harmonized criteria. Glucose tolerance was assessed by oral glucose tolerance test (OGTT). CVD, depressive symptoms, and use of antidepressant medication were self-reported.
   Results. The odds for having the MetS increased over 10% for each standard deviation increase in depressive symptoms. Users of antidepressant medication had more than 50% increased odds for having the MetS. Depressive symptoms were also associated with higher glucose response during the OGTT, higher serum triglyceride and lower HDL-cholesterol concentrations, and higher waist circumference, while use of antidepressant medication was associated with higher triglycerides, waist circumference, and systolic blood pressure. The associations of depressive symptoms were not secondary to use of antidepressant medication and were not explained by established diabetes or CVD.
   Discussion. Depressive symptoms, the MetS, and the individual components of MetS are related. These associations are not driven by use of antidepressant medication, established diabetes, or CVD.
C1 [Pyykkonen, Antti-Jussi; Raikkonen, Katri] Univ Helsinki, Inst Behav Sci, FIN-00014 Helsinki, Finland.
   [Pyykkonen, Antti-Jussi; Tuomi, Tiinamaija; Eriksson, Johan G.; Isomaa, Bo] Folkhalsan Res Ctr, Helsinki, Finland.
   [Tuomi, Tiinamaija; Groop, Leif] Univ Helsinki, Cent Hosp, Dept Med, FIN-00014 Helsinki, Finland.
   [Tuomi, Tiinamaija; Groop, Leif] Univ Helsinki, Res Program Mol Med, FIN-00014 Helsinki, Finland.
   [Eriksson, Johan G.] Univ Helsinki, Dept Gen Practice & Primary Hlth Care, FIN-00014 Helsinki, Finland.
   [Eriksson, Johan G.] Natl Inst Hlth & Welf, Helsinki, Finland.
   [Eriksson, Johan G.] Univ Helsinki, Cent Hosp, Unit Gen Practice, FIN-00014 Helsinki, Finland.
   [Eriksson, Johan G.] Vasa Cent Hosp, Vaasa, Finland.
   [Groop, Leif] Lund Univ, Malmo Univ Hosp, Clin Res Ctr, Dept Clin Sci Diabet & Endocrinol, Malmo, Sweden.
   [Isomaa, Bo] Dept Social Serv & Hlth Care, Jakobstad, Sweden.
C3 University of Helsinki; Folkhalsan Research Center; University of
   Helsinki; Helsinki University Central Hospital; University of Helsinki;
   University of Helsinki; Finland National Institute for Health & Welfare;
   University of Helsinki; Helsinki University Central Hospital; Vaasa
   Central Hospital; Lund University; Skane University Hospital
RP Räikkönen, K (corresponding author), Univ Helsinki, Inst Behav Sci, POB 9,Siltavuorenpenger 1 A, FIN-00014 Helsinki, Finland.
EM katri.raikkonen@helsinki.fi
RI Gibbs, J. Raphael/A-3984-2010
OI Tuomi, Tiinamaija/0000-0002-8306-6202; Raikkonen,
   Katri/0000-0003-3124-3470; Eriksson, Johan/0000-0002-2516-2060
FU Eli Lilly; Novartis; European Science Foundation (EuroSTRESS); Finnish
   Academy; Sigrid Juselius Foundation; Folkhalsan Research Foundation;
   Nordic Center of Excellence in Disease Genetics; Signe and Ane
   Gyllenberg Foundation; Swedish Cultural Foundation in Finland; Finnish
   Diabetes Research Foundation; Foundation for Life and Health in Finland;
   Finnish Medical Society; Finnish Ministry of Education; Paavo Nurmi
   Foundation; Perklen Foundation; Ollqvist Foundation; Narpes Health Care
   Foundation; Municipal Health Care Center and Hospital in Jakobstad,
   Health Care Centers in Vasa, Narpes, and Korsholm
FX The authors (Katri Raikkonen, Antti-Jussi Pyykkonen, Tiinamaija Tuomi,
   and Bo Isomaa) declare no conflict of interest. Leif Groop has been a
   consultant for and served on advisory boards for Sanofi-aventis,
   GlaxoSmithKline, Novartis, Merck, Tethys Bioscience, and Xoma and
   received lecture fees from Eli Lilly and Novartis. Johan G. Eriksson has
   been a consultant for and served on advisory boards for MSD,
   Bristol-Myers Squibb, AstraZeneca, Eli Lilly, and NovoNordisk. The
   PPP-Botnia study has been financially supported by grants from the
   European Science Foundation (EuroSTRESS), the Finnish Academy, the
   Sigrid Juselius Foundation, Folkhalsan Research Foundation, Nordic
   Center of Excellence in Disease Genetics, Signe and Ane Gyllenberg
   Foundation, Swedish Cultural Foundation in Finland, Finnish Diabetes
   Research Foundation, Foundation for Life and Health in Finland, Finnish
   Medical Society, the Finnish Ministry of Education, Paavo Nurmi
   Foundation, Perklen Foundation, Ollqvist Foundation, and Narpes Health
   Care Foundation. The study has also been supported by the Municipal
   Health Care Center and Hospital in Jakobstad, Health Care Centers in
   Vasa, Narpes, and Korsholm.
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NR 36
TC 26
Z9 30
U1 0
U2 7
PU INFORMA HEALTHCARE
PI NEW YORK
PA 52 VANDERBILT AVE, NEW YORK, NY 10017 USA
SN 0785-3890
J9 ANN MED
JI Ann. Med.
PD MAY
PY 2012
VL 44
IS 3
BP 279
EP 288
DI 10.3109/07853890.2010.543921
PG 10
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 919JE
UT WOS:000302319700009
PM 21254903
DA 2025-06-11
ER

PT J
AU Jia, F
   Shi, SY
   Fei, SF
   Zhou, M
   Li, JJ
AF Jia, Fang
   Shi, Shun-Yi
   Fei, Si-Fan
   Zhou, Min
   Li, Jian-Jun
TI Association of Insomnia, Lipid Profile, and Lipid-Lowering Medications:
   A Narrative Review
SO REVIEWS IN CARDIOVASCULAR MEDICINE
LA English
DT Review
DE insomnia; lipid metabolism; coronary artery disease; statin; proprotein
   convertase subtilisin/kexin type 9 inhibitors (PCSK9i)
ID SLEEP DURATION; METABOLIC SYNDROME; ELEVATED GHRELIN; HPA AXIS;
   POPULATION; SYMPTOMS; RISK; CHOLESTEROL; DEPRESSION; CORTISOL
AB Sleep is a fundamental phenomenon that helps maintain normal physiological processes. Conversely, sleep disorders, usually presented as insomnia, are a common public health problem that can lead to multiple pathophysiological changes in humans, including lipid metabolic abnormality. Interestingly, several previous studies have examined the potential relation of insomnia to metabolic syndrome and hyperlipidemia and found that insomnia was associated with elevated plasma cholesterol and triglyceride concentrations. This review summarizes evidence regarding the linkage between insomnia and lipid abnormalities. Moreover, the underlying physiologic mechanisms linking insomnia to lipid abnormalities are systemically discussed. Finally, issues with lipid-lowering drugs and the risk of insomnia are also presented. This knowledge can improve our understanding of the pathophysiological features of insomnia, which may help to prevent and treat insomnia-induced dyslipidemia clinically.
C1 [Jia, Fang; Shi, Shun-Yi; Fei, Si-Fan; Zhou, Min] Soochow Univ, Affiliated Hosp 3, Dept Cardiol, Changzhou 213003, Jiangsu, Peoples R China.
   [Li, Jian-Jun] Chinese Acad Med Sci, Fu Wai Hosp, Peking Union Med Coll, Cardiometab Ctr, Beijing, Peoples R China.
C3 Soochow University - China; Chinese Academy of Medical Sciences - Peking
   Union Medical College; Fu Wai Hospital - CAMS; Peking Union Medical
   College
RP Jia, F (corresponding author), Soochow Univ, Affiliated Hosp 3, Dept Cardiol, Changzhou 213003, Jiangsu, Peoples R China.; Li, JJ (corresponding author), Chinese Acad Med Sci, Fu Wai Hosp, Peking Union Med Coll, Cardiometab Ctr, Beijing, Peoples R China.
EM jiafangsjs@126.com; lijianjun938@126.com
RI Shi, Shun-yi/HJG-5245-2022
OI , Fang/0000-0002-6828-2847
FU Major Technology Projects of Changzhou Health Commission
FX Not applicable.
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NR 137
TC 0
Z9 0
U1 3
U2 3
PU IMR PRESS
PI ROBINSON
PA 112 ROBINSON RD, ROBINSON, SINGAPORE
SN 1530-6550
EI 2153-8174
J9 REV CARDIOVASC MED
JI Rev. Cardiovasc. Med.
PD JAN 15
PY 2025
VL 26
IS 1
AR 24978
DI 10.31083/RCM24978
PG 17
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA T6W5H
UT WOS:001406383200004
PM 39867194
OA gold
DA 2025-06-11
ER

PT J
AU Assies, J
   Pouwer, F
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   Visser, I
   Abeling, NGGM
   Duran, M
   Schene, AH
AF Assies, Johanna
   Pouwer, Francois
   Lok, Anja
   Mocking, Roel J. T.
   Bockting, Claudi L. H.
   Visser, Ieke
   Abeling, Nico G. G. M.
   Duran, Marinus
   Schene, Aart H.
TI Plasma and Erythrocyte Fatty Acid Patterns in Patients with Recurrent
   Depression: A Matched Case-Control Study
SO PLOS ONE
LA English
DT Article
ID METABOLIC SYNDROME; CARDIOVASCULAR MORTALITY; OXIDATIVE STRESS;
   DISORDER; MOOD; OMEGA-3-FATTY-ACIDS; DESATURASE; BIPOLAR; CORTEX; BLOOD
AB Background: The polyunsaturated fatty acid (PUFA) composition of (nerve) cell membranes may be involved in the pathophysiology of depression. Studies so far, focussed mainly on omega-3 and omega-6 PUFAs. In the present study, saturated fatty acids (SFAs), monounsaturated fatty acids (MUFAs) and PUFAs of the omega-3, -6 and -9 series in plasma and erythrocytes of patients with recurrent major depressive disorder (MDD-R) were compared with controls.
   Methodology and Principal Findings: We carried out a case-control study. The sample consisted of 137 patients with MDD-R and 65 matched non-depressed controls. In plasma and erythrocytes of patients with MDD-R the concentrations of most of the SFAs and MUFAs, and additionally erythrocyte PUFAs, all with a chain length >20 carbon (C) atoms, were significantly lower than in the controls. In contrast, the concentrations of most of the shorter chain members (<= 18C) of the SFAs and MUFAs were significantly higher in the patients. Estimated activities of several elongases in plasma of patients were significantly altered, whereas delta-9 desaturase activity for C14:0 and C18:0 was significantly higher.
   Conclusions/Significance: The fatty acid status of patients with MDD-R not only differs with regard to omega-3 and omega-6 PUFAs, but also concerns other fatty acids. These alterations may be due to: differences in diet, changes in synthesizing enzyme activities, higher levels of chronic (oxidative) stress but may also result from adaptive strategies by providing protection against enhanced oxidative stress and production of free radicals.
C1 [Assies, Johanna; Lok, Anja; Mocking, Roel J. T.; Visser, Ieke; Schene, Aart H.] Univ Amsterdam, Acad Med Ctr, Dept Psychiat, Program Mood Disorders, NL-1105 AZ Amsterdam, Netherlands.
   [Pouwer, Francois] Tilburg Univ, Dept Med Psychol & Neuropsychol, Ctr Res Psychol Somat Dis CoRPS, NL-5000 LE Tilburg, Netherlands.
   [Bockting, Claudi L. H.] Univ Groningen, Dept Clin Psychol, Groningen, Netherlands.
   [Visser, Ieke] PsyQ Mental Heath Care, Zaandam, Netherlands.
   [Abeling, Nico G. G. M.; Duran, Marinus] Univ Amsterdam, Acad Med Ctr, Lab Genet Metab Dis, NL-1105 AZ Amsterdam, Netherlands.
C3 University of Amsterdam; Academic Medical Center Amsterdam; Tilburg
   University; University of Groningen; University of Amsterdam; Academic
   Medical Center Amsterdam
RP Assies, J (corresponding author), Univ Amsterdam, Acad Med Ctr, Dept Psychiat, Program Mood Disorders, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands.
EM j.assies@amc.uva.nl
RI Schene, A.H./H-8085-2014; Bockting, Claudi/K-3768-2019; Mocking,
   Roel/H-8131-2012
OI Bockting, Claudi L.H./0000-0002-9220-9244; Pouwer,
   Frans/0000-0002-8172-9818; Mocking, Roel/0000-0003-3543-3810
FU Health Research Development Counsel (ZonMw); Department Prevention
   Program; National Foundation for Mental Health (Fonds Psychische
   Gezondheid)
FX This study was granted by the Health Research Development Counsel
   (ZonMw), Department Prevention Program and National Foundation for
   Mental Health (Fonds Psychische Gezondheid). The funders had no role in
   study design, data collection and analysis, decision to publish, or
   preparation of the manuscript.
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NR 41
TC 108
Z9 115
U1 0
U2 13
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAY 14
PY 2010
VL 5
IS 5
AR e10635
DI 10.1371/journal.pone.0010635
PG 9
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 597PU
UT WOS:000277771600005
PM 20498721
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Jung, CH
   Lee, JS
   Ahn, HJ
   Choi, JS
   Noh, MY
   Lee, JJ
   Lee, EY
   Lim, JH
   Lee, YR
   Yoon, SY
   Kim, CH
   Cho, DH
   Choi, YS
   Choi, KM
AF Jung, Chan-Hee
   Lee, Ji Sung
   Ahn, Hee Jung
   Choi, Jin-Sun
   Noh, Min Young
   Lee, Ji Jeung
   Lee, Eun Young
   Lim, Jeong Hyun
   Lee, Young Ran
   Yoon, So Yoon
   Kim, Chong Hwa
   Cho, Dong-Hyeok
   Choi, Young Sik
   Choi, Kyung Mook
TI Association of meal frequency with metabolic syndrome in Korean adults:
   from the Korea National Health and Nutrition Examination Survey
   (KNHANES)
SO DIABETOLOGY & METABOLIC SYNDROME
LA English
DT Article
DE Meal frequency; Metabolic syndrome; Korean National Health and Nutrition
   Examination Survey
ID MIDDLE-AGED MEN; EATING FREQUENCY; CALORIC RESTRICTION;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; NORMAL-WEIGHT; RISK-FACTOR; WOMEN;
   PREVALENCE; OBESITY
AB Background: Although previous studies have established a close relationship between caloric intake and metabolic syndrome, there is limited research exploring the impact of meal frequency adjusted by caloric intake on metabolic syndrome (MetS).
   Objective: To evaluate the association of meal frequency and MetS after adjusting for confounding factors including caloric intake in Korean men and women.
   Methods: We analyzed the national representative data of a total 12,389 adults (5171 men, 7218 women) from the Korean National Health and Nutrition Examination Survey (KNHANES) 2010-2012. Subjects were categorized as eating 3 meals/day (MF3) or 2 or fewer meals/day (MF <= 2). Daily caloric intake was calculated using CAN-Pro 4.0 (The Korean Nutrition Society, Seoul, Korea).
   Results: The prevalence of components of MetS differed significantly according to meal frequency in both men and women. In an unadjusted analysis, the prevalence of MetS in women was significantly higher in the MF3 group than the MF <= 2 group (27.5% vs. 17.8%, P < 0.001), whereas the prevalence of MetS in men did not differ between the MF3 and MF <= 2 groups (24.6% vs. 22.7%, P = 0.281). However, after adjusting for age, caloric intake, smoking status, alcohol consumption, physical activity, income, and education level, men in the MF = 2 group had an increased risk of metabolic syndrome compared to men in the MF3 group (OR = 1.37, 95%, CI = 1.12-1.67). On the other hand, meal frequency did not affect the risk of metabolic syndrome in women after adjusting for confounding factors including caloric intake (OR = 1.09, 95%, CI = 0.90-1.31).
   Conclusions: This study suggests that lower meal frequency adjusted for caloric intake, physical activity, age, smoking, alcohol, income, and education may be associated with increased risk of MetS in Korean men.
C1 [Jung, Chan-Hee; Choi, Kyung Mook] Soonchunhyang Univ, Dept Internal Med, Sch Med, Div Endocrinol & Metab, Bucheon, South Korea.
   [Lee, Ji Sung] Asan Med Ctr, Clin Res Ctr, Seoul, South Korea.
   [Ahn, Hee Jung] Eulji Hosp, Dept Nutr, Seoul, South Korea.
   [Choi, Jin-Sun] Sungkyunkwan Univ, Kangbuk Samsung Hosp, Dept Nutr, Seoul, South Korea.
   [Noh, Min Young] Catholic Univ, Seoul St Marys Hosp, Dept Nutr, Seoul, South Korea.
   [Lee, Ji Jeung] Inje Univ, Dept Nutr, Sanggye Paik Hosp, Seoul, South Korea.
   [Lee, Eun Young] Inje Univ, Dept Nutr Serv, Ilsanpaik Hosp, Ilsan, South Korea.
   [Lim, Jeong Hyun] Seoul Natl Univ Hosp, Dept Food Serv & Nutr Care, Seoul, South Korea.
   [Lee, Young Ran] Dongtan Sacred Heart Hosp, Dept Nutr, Dongtan, South Korea.
   [Yoon, So Yoon] Asan Med Ctr, Dept Dietet, Seoul, South Korea.
   [Yoon, So Yoon] Asan Med Ctr, Nutr Serv Team, Seoul, South Korea.
   [Kim, Chong Hwa] Sejong Gen Hosp, Dept Internal Med, Bucheon, South Korea.
   [Cho, Dong-Hyeok] Chonnam Natl Univ Hosp, Dept Internal Med, Gwangju, South Korea.
   [Choi, Young Sik] Kosin Univ, Coll Med, Dept Internal Med, Busan, South Korea.
   [Choi, Kyung Mook] Korea Univ, Guro Hosp, Dept Internal Med, Div Endocrinol & Metab, 80 Guro Dong, Seoul 152050, South Korea.
C3 Soonchunhyang University; University of Ulsan; Asan Medical Center;
   Samsung; Eulji University; Sungkyunkwan University (SKKU); Samsung
   Medical Center; Catholic University of Korea; Seoul St. Mary's Hospital;
   Inje University; Inje University; Seoul National University (SNU); Seoul
   National University Hospital; University of Ulsan; Asan Medical Center;
   University of Ulsan; Asan Medical Center; Sejong General Hospital;
   Chonnam National University; Chonnam National University Hospital; Korea
   University; Korea University Medicine (KU Medicine)
RP Choi, KM (corresponding author), Korea Univ, Guro Hosp, Dept Internal Med, Div Endocrinol & Metab, 80 Guro Dong, Seoul 152050, South Korea.
EM medica7@gmail.com
RI Kim, Yun Hak/ABF-3331-2021; Choi, Kyung/C-4195-2018; Jung,
   Chan-Hee/AAV-3164-2020
OI Choi, Kyung Mook/0000-0001-6175-0225
FU Korean Health Technology R& D Project, Ministry of Health & Welfare,
   Republic of Korea [HI14C0133]; Soonchunhyang University
FX This study was supported by a grant of the Korean Health Technology R& D
   Project, Ministry of Health & Welfare, Republic of Korea ( HI14C0133)
   and by grant from Soonchunhyang University.
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NR 34
TC 18
Z9 19
U1 0
U2 4
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1758-5996
J9 DIABETOL METAB SYNDR
JI Diabetol. Metab. Syndr.
PD OCT 3
PY 2017
VL 9
AR 77
DI 10.1186/s13098-017-0277-2
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA FI7LU
UT WOS:000412179100002
PM 29026444
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Ogonowski, N
   Mikusic, NLR
   Kouyoumdzian, NM
   Choi, MR
   Fellet, A
   Balaszczuk, AM
   Celuch, SM
AF Ogonowski, Natalia
   Rukavina Mikusic, Natalia Lucia
   Kouyoumdzian, Nicolas Martin
   Choi, Marcelo Roberto
   Fellet, Andrea
   Balaszczuk, Ana Maria
   Celuch, Stella Maris
TI Cardiotoxic Effects of the Antineoplastic Doxorubicin in a Model of
   Metabolic Syndrome: Oxidative Stress and Transporter Expression in the
   Heart
SO JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
LA English
DT Article
DE metabolic syndrome; heart; doxorubicin; membrane transporters;
   P-glycoprotein; oxidative stress markers
ID BLOOD-BRAIN-BARRIER; P-GLYCOPROTEIN; EFFLUX TRANSPORTERS;
   INSULIN-RESISTANCE; LIPID-METABOLISM; CARNITINE UPTAKE; RAT; PROTEIN;
   ACID; CARDIOMYOCYTES
AB The aim of the present work was to examine whether metabolic syndrome-like conditions in rats with fructose (F) overload modify the cardiotoxic effects induced by doxorubicin (DOX) and whether the treatment altered the expression of P-gp, breast cancer resistance protein, and organic cation/carnitine transporters in the heart. Male Sprague-Dawley rats received either tap water (control group [C]; n = 16) or water with F 10% wt/vol (n = 16) during 8 weeks. Three days before being killed, the animals received a single dose of DOX (6 mg/kg, ip, md) (C-DOX and F-DOX groups) or vehicle (VEH; ISS 1 mL/kg BW; ip) (C-VEH and F-VEH groups) (n = 8 per group). F overload enhanced thiobarbituric acid-reactive substance levels in the left ventricle, and DOX injection further increased those values. DOX did not alter thiobarbituric acid-reactive substance production in C animals. DOX caused a decrease of 30% in the ejection fraction and a nearly 40% reduction in the fractional shortening in F animals, but not in C rats. Cardiac tissue levels of P-gp decreased by about 30% in F rats compared with the C groups. DOX did not modify cardiac P-gp expression. Breast cancer resistance protein and organic cation/carnitine transporter (OCTN 1/2/3) protein levels did not change with either F or DOX. It is suggested that DOX could cause greater cardiotoxicity in rats receiving F, probably due to enhanced cardiac lipid peroxidation and lower expression of cardiac P-gp. These results support the hypothesis that the cardiotoxicity of DOX could be increased under metabolic syndrome-like conditions or in other health disorders that involve cardiovascular risk factors.
C1 [Ogonowski, Natalia; Fellet, Andrea; Balaszczuk, Ana Maria] Univ Buenos Aires, Fac Farm & Bioquim, Inst Quim & Metabolismo Farmaco, Dept Ciencias Biol,Catedra Fisiol,CONICET, Buenos Aires, Argentina.
   [Rukavina Mikusic, Natalia Lucia; Choi, Marcelo Roberto] Univ Buenos Aires, Fac Farm & Bioquim, Dept Ciencias Biol, Catedra Anat & Histol, Buenos Aires, Argentina.
   [Kouyoumdzian, Nicolas Martin; Choi, Marcelo Roberto] Univ Buenos Aires, Inst Alberto C Taquini Invest Med Traslac IATIMET, CONICET, Buenos Aires, Argentina.
   [Celuch, Stella Maris] Univ Buenos Aires, Fac Farm & Bioquim, Inst Invest Farmacol, CONICET, Buenos Aires, Argentina.
C3 University of Buenos Aires; Consejo Nacional de Investigaciones
   Cientificas y Tecnicas (CONICET); University of Buenos Aires; Consejo
   Nacional de Investigaciones Cientificas y Tecnicas (CONICET); University
   of Buenos Aires; University of Buenos Aires; Consejo Nacional de
   Investigaciones Cientificas y Tecnicas (CONICET)
RP Ogonowski, N (corresponding author), Univ Buenos Aires, Fac Farm & Bioquim, Inst Quim & Metabolismo Farmaco, Dept Ciencias Biol,Catedra Fisiol,CONICET, Buenos Aires, Argentina.
EM n.ogonowski@conicet.gov.ar
RI Choi, Marcelo/I-4082-2019
OI Choi, Marcelo/0000-0003-2909-8534; Ogonowski, Natalia
   Soledad/0000-0002-0090-3184
FU National Scientific and Technical Research Council (CONICET) [PIP
   112-201201-00425]
FX Supported by a grant from the National Scientific and Technical Research
   Council (CONICET) (PIP 112-201201-00425).
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NR 79
TC 5
Z9 5
U1 1
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0160-2446
EI 1533-4023
J9 J CARDIOVASC PHARM
JI J. Cardiovasc. Pharmacol.
PD DEC
PY 2021
VL 78
IS 6
BP 784
EP 791
PG 8
WC Cardiac & Cardiovascular Systems; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Pharmacology & Pharmacy
GA 0Z6GX
UT WOS:000791175700003
PM 34524257
DA 2025-06-11
ER

PT J
AU Mathew, AV
   Li, L
   Byun, J
   Guo, YH
   Michailidis, G
   Jaiswal, M
   Chen, YE
   Pop-Busui, R
   Pennathur, S
AF Mathew, Anna V.
   Li, Lei
   Byun, Jaeman
   Guo, Yanhong
   Michailidis, George
   Jaiswal, Mamta
   Chen, Y. Eugene
   Pop-Busui, Rodica
   Pennathur, Subramaniam
TI Therapeutic Lifestyle Changes Improve HDL Function by Inhibiting
   Myeloperoxidase-Mediated Oxidation in Patients With Metabolic Syndrome
SO DIABETES CARE
LA English
DT Article
ID HIGH-DENSITY-LIPOPROTEIN; CHOLESTEROL EFFLUX CAPACITY; WEIGHT-LOSS;
   DIET; EXERCISE; INFLAMMATION; STRESS; PLASMA; INTERVENTION; FRAMINGHAM
AB OBJECTIVEPhagocyte-derived myeloperoxidase (MPO) and proinflammatory HDL are associated with metabolic syndrome (MetS) and increased cardiovascular disease risk. Therapeutic lifestyle changes (TLCs), such as a Mediterranean diet and exercise, decrease this risk. However, the link among TLCs, HDL, and MPO-mediated oxidative stress remains unclear.RESEARCH DESIGN AND METHODSIn this study, we characterized changes in cholesterol efflux capacity (CEC), a metric of HDL function; MPO-mediated oxidation; and the HDL proteomic profile in 25 patients with MetS who underwent 12 weeks of TLCs.RESULTSAfter 12 weeks, before significant changes to HDL levels, most MetS components improved as a result of the TLCs. CEC was significantly increased, and HDL MPO oxidation products, 3-chlorotyrosine and 3-nitrotyrosine, were decreased with TLCs. The changes in CEC were inversely related to the unit changes in 3-chlorotyrosine after we controlled for changes in the other MetS components. TLCs did not remodel the HDL proteome.CONCLUSIONSIn summary, TLCs improved HDL function by inhibiting MPO-mediated oxidative stress even before appreciable changes in HDL levels.
C1 [Mathew, Anna V.; Byun, Jaeman; Pennathur, Subramaniam] Univ Michigan, Dept Internal Med, Div Nephrol, Ann Arbor, MI 48109 USA.
   [Li, Lei] Peking Univ, Hlth Sci Ctr, Beijing, Peoples R China.
   [Guo, Yanhong; Chen, Y. Eugene] Univ Michigan, Dept Cardiac Surg, Ann Arbor, MI 48109 USA.
   [Michailidis, George] Univ Florida, Gainesville, FL USA.
   [Jaiswal, Mamta; Pop-Busui, Rodica] Univ Michigan, Dept Internal Med, Div Metab Endocrinol & Diabet, Ann Arbor, MI 48109 USA.
   [Pennathur, Subramaniam] Univ Michigan, Dept Mol & Integrat Physiol, Ann Arbor, MI 48109 USA.
C3 University of Michigan System; University of Michigan; Peking
   University; University of Michigan System; University of Michigan; State
   University System of Florida; University of Florida; University of
   Michigan System; University of Michigan; University of Michigan System;
   University of Michigan
RP Pennathur, S (corresponding author), Univ Michigan, Dept Internal Med, Div Nephrol, Ann Arbor, MI 48109 USA.; Pennathur, S (corresponding author), Univ Michigan, Dept Mol & Integrat Physiol, Ann Arbor, MI 48109 USA.
EM spennath@umich.edu
RI Pennathur, Subramaniam/O-7032-2017; Mathew, Anna/IZE-4291-2023
OI Mathew, Anna/0000-0002-7043-4221; Pennathur,
   Subramaniam/0000-0003-3628-6883; Pop-Busui, Rodica/0000-0002-2042-1350
FU National Institute of Diabetes and Digestive and Kidney Diseases,
   National Institutes of Health [P30-DK-081943, P30-DK-089503]; National
   Heart, Lung, and Blood Institute, National Institutes of Health
   [K08-HL-130944, R01-HL-129778]; National Institute of Diabetes and
   Digestive and Kidney Diseases [P30DK020572, P30DK081943, P30DK092926,
   P30DK089503] Funding Source: NIH RePORTER
FX This work was supported in part by grants from the National Institute of
   Diabetes and Digestive and Kidney Diseases, National Institutes of
   Health (P30-DK-081943 and P30-DK-089503), and the National Heart, Lung,
   and Blood Institute, National Institutes of Health (K08-HL-130944 and
   R01-HL-129778).
CR Aguilar M, 2015, JAMA-J AM MED ASSOC, V313, P1973, DOI 10.1001/jama.2015.4260
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NR 31
TC 29
Z9 30
U1 0
U2 15
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0149-5992
EI 1935-5548
J9 DIABETES CARE
JI Diabetes Care
PD NOV
PY 2018
VL 41
IS 11
BP 2431
EP 2437
DI 10.2337/dc18-0049
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA GX5YM
UT WOS:000447831700025
PM 30201848
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Kuneinen, S
   Kaaja, RJ
   Vahlberg, TJ
   Korhonen, PE
AF Kuneinen, Susanna
   Kaaja, Risto J.
   Vahlberg, Tero J.
   Korhonen, Paivi E.
TI Metabolic syndrome is not associated with erectile dysfunction in
   apparently healthy men
SO PRIMARY CARE DIABETES
LA English
DT Article
DE Metabolic syndrome; Erectile dysfunction; Depressive symptoms;
   Testosterone
AB Aims: To investigate whether metabolic syndrome (MetS) is associated with erectile dysfunction (ED) among apparently healthy men when depressive symptoms and serum testosterone levels are taken into account.
   Methods: A study population of 549 men at risk for cardiovascular disease or type 2 diabetes was drawn from the participants of a population survey, the Harmonica Project. MetS was diagnosed with the United States National Cholesterol Education Program Third Adult Treatment Panel (ATPIII) 2005 definition, the International Diabetes Federation (IDF) 2005 definition and the Harmonization 2009 definition. ED was evaluated by the International Index of Erectile Function (IIEF-5) questionnaire. Depressive symptoms were assessed with Beck's Depression Inventory (BDI).
   Results: Of the 549 men (mean age 58.4 +/- 6.7 years), 56.5 % reported ED. The prevalence of MetS was 48.6%, 35.5%, and 50.6% according to the IDF, the ATPIII, and the Harmonization criteria, respectively. We found no difference in the prevalence of ED between men with or without MetS. In a multivariate analysis, age, presence of depressive symptoms and lower education were significant predictors of ED.
   Conclusions: The prevalence of ED is quite high even in apparently healthy men. Depressive symptoms are a critical component to consider in men suffering from ED. (C) 2019 Primary Care Diabetes Europe. Published by Elsevier Ltd. All rights reserved.
C1 [Kuneinen, Susanna; Korhonen, Paivi E.] Cent Satakunta Hlth Federat Municipal, Harjavalta, Finland.
   [Kuneinen, Susanna; Korhonen, Paivi E.] Turku Univ, Dept Gen Practice, Turku 20014, Finland.
   [Kuneinen, Susanna; Kaaja, Risto J.; Korhonen, Paivi E.] Turku Univ Hosp, Turku, Finland.
   [Kaaja, Risto J.] Univ Turku, Inst Clin Med, Internal Med, Turku, Finland.
   [Vahlberg, Tero J.] Univ Turku, Dept Biostat, Turku, Finland.
C3 University of Turku; University of Turku; University of Turku;
   University of Turku
RP Kuneinen, S (corresponding author), Turku Univ, Dept Gen Practice, Turku 20014, Finland.
EM smkune@utu.fi
FU State Provincial Office of Western Finland; Central Satakunta Health
   Federation of Municipalities
FX This research was supported by the State Provincial Office of Western
   Finland and the Central Satakunta Health Federation of Municipalities.
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   World Health Organization, Fact sheet on cardiovascular diseases (CVDs)
NR 20
TC 5
Z9 5
U1 0
U2 2
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 1751-9918
EI 1878-0210
J9 PRIM CARE DIABETES
JI Prim. Care Diabetes
PD OCT
PY 2020
VL 14
IS 5
BP 460
EP 463
DI 10.1016/j.pcd.2019.12.008
PG 4
WC Endocrinology & Metabolism; Primary Health Care
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; General & Internal Medicine
GA NU4TG
UT WOS:000573635200012
PM 31917120
DA 2025-06-11
ER

PT J
AU Deetman, PE
   Bakker, SJL
   Dullaart, RPF
AF Deetman, Petronella E.
   Bakker, Stephan J. L.
   Dullaart, Robin P. F.
TI High sensitive C-reactive protein and serum amyloid A are inversely
   related to serum bilirubin: effect-modification by metabolic syndrome
SO CARDIOVASCULAR DIABETOLOGY
LA English
DT Article
DE Metabolic syndrome; Serum amyloid A; Bilirubin
ID HIGH-DENSITY-LIPOPROTEIN; OXIDATIVE STRESS; PARAOXONASE-1 ACTIVITY;
   ATHEROSCLEROSIS; INFLAMMATION; DISEASE; PREDICTION; PARTICLES; EVENTS;
   ADULTS
AB Background: Bilirubin has been implicated in cardiovascular protection by virtue of its anti-inflammatory and anti-oxidative properties. The metabolic syndrome is featured by enhanced low-grade systemic inflammation and oxidative stress. Serum amyloid A (SAA) impairs anti-oxidative properties of high-density lipoprotein (HDL). We determined relationships of high sensitive C-reactive protein (hs-CRP) and SAA with bilirubin in subjects with and without metabolic syndrome (MetS).
   Methods: Serum total bilirubin, hs-CRP, SAA and homeostasis model assessment-insulin resistance (HOMA-IR) were documented in 94 subjects with and in 73 subjects without MetS (26 and 54 subjects with type 2 diabetes mellitus (T2DM), respectively).
   Results: Bilirubin was lower in MetS (P = 0.013), coinciding with higher hs-CRP (P < 0.001) and SAA levels (P = 0.002). In all subjects combined, hs-CRP was inversely related to bilirubin (r = -0.203, P = 0.008), irrespective of the presence of MetS or T2DM (interaction terms: P >= 0.75). The inverse relationship of bilirubin with SAA was confined to subjects without MetS (r = -0.267, P = 0.009). Furthermore, the presence of either MetS or T2DM modified the relationship of bilirubin with SAA (interaction terms: beta = 0.366, P = 0.003 and beta = 0.289, P = 0.025, respectively) in age-and sex-adjusted analyses. Effect modification was also found for HOMA-IR (beta = 0.790, P = 0.020). Of the individual MetS components, the strongest interaction of bilirubin on SAA was observed with low HDL cholesterol (beta = 0.435, P < 0.001).
   Conclusions: hs-CRP is inversely related to bilirubin, suggesting that low bilirubin is implicated in enhanced low-grade systemic inflammation. The inverse relationship of SAA with bilirubin was found to be absent in MetS, which could be attributable to MetS-associated abnormalities in HDL characteristics.
C1 [Deetman, Petronella E.; Bakker, Stephan J. L.] Univ Groningen, Univ Med Ctr Groningen, Dept Nephrol, NL-9700 RB Groningen, Netherlands.
   [Dullaart, Robin P. F.] Univ Groningen, Univ Med Ctr Groningen, Dept Endocrinol, NL-9700 RB Groningen, Netherlands.
C3 University of Groningen; University of Groningen
RP Dullaart, RPF (corresponding author), Univ Groningen, Univ Med Ctr Groningen, Dept Endocrinol, POB 30-001, NL-9700 RB Groningen, Netherlands.
EM r.p.f.dullaart@umcg.nl
RI Bakker, Stephan/J-4023-2015
OI Bakker, Stephan/0000-0003-3356-6791
FU Dutch Diabetes Research Foundation [2001.00.012]
FX R.P.F. Dullaart is supported by a grant from the Dutch Diabetes Research
   Foundation (grant 2001.00.012). R. de Vries, MD, PhD is acknowledged for
   data collection. Plasma lipids were determined in the laboratory of Dr.
   L. D. Dikkeschei, PhD, Laboratory of Clinical Chemistry, Isala Clinics,
   Zwolle, The Netherlands. Johan Bijzet, Department of Rheumatology &
   Clinical Immunology, University of Groningen, The Netherlands, performed
   the serum amyloid A assays.
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NR 42
TC 34
Z9 35
U1 0
U2 6
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1475-2840
J9 CARDIOVASC DIABETOL
JI Cardiovasc. Diabetol.
PD NOV 9
PY 2013
VL 12
AR 166
DI 10.1186/1475-2840-12-166
PG 8
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism
GA 260TA
UT WOS:000327616100001
PM 24209691
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Susam, I
   Yaylali, YT
   Dursunoglu, D
   Göksoy, H
   Öztürk, M
   Yaylali, O
   Semiz, E
AF Susam, Ibrahim
   Yaylali, Yalin Tolga
   Dursunoglu, Dursun
   Goksoy, Hidayet
   Ozturk, Mehmet
   Yaylali, Olga
   Semiz, Ender
TI Decreased plasma adiponectin concentrations in patients with syndrome X
SO ACTA CARDIOLOGICA
LA English
DT Article
DE Adiponectin; syndrome X; coronary risk; coronary artery disease
ID C-REACTIVE PROTEIN; CORONARY-ARTERY-DISEASE; INSULIN-RESISTANCE;
   INFLAMMATORY MARKERS; ADIPOSE-TISSUE; ASSOCIATION; EXPRESSION; WOMEN;
   ISCHEMIA; HYPOADIPONECTINEMIA
AB Objective - The levels of adiponectin, an anti-atherogenic protein, are decreased in patients with coronary artery disease. Syndrome X is associated with endothelial dysfunction, which is a key feature in the evolution of atherosclerosis. We sought to determine whether serum adiponectin levels are decreased in patients with syndrome X.
   Methods - Twenty-three syndrome X patients (14 men, 9 women) who presented with stable angina pectoris, had a positive non-invasive stress test or an abnormal myocardial perfusion scintigraphy single photon emission computed tomography (MPS SPECT) and a normal coronary angiogram, were included in our study, as were 17 asymptomatic healthy subjects (13 men, 4 women) with normal results from non-invasive stress testing. The serum adiponectin levels and lipid profiles of the patients and control subjects were determined with venous samples collected after a 12-hour fast. The results were analysed by a Mann Whitney U test.
   Results - Mean age (54.1 +/- 11.8 y in patients and 59.8 +/- 9.6 y in control subjects, P>0.05) and body mass index (28.0 +/- 3.3 in patients and 27.1 +/- 4.2 in control subjects, P>0.05) did not differ between the two groups.Adiponectin levels in patients with syndrome X (1.5 +/- 1.1 mu g/dl) were significantly lower than those in the control group (5.3 +/- 2.9 mu g/dl, P < 0.0001). Serum total cholesterol (TCHOL), triglyceride (TG), LDL, and HDL-cholesterol levels did not differ between the two groups (P>0.05).
   Conclusion - Serum adiponectin levels were lower in patients with syndrome X, and these low adiponectin concentrations may cause endothelial dysfunction. Thus, patients with a marked drop in adiponectin levels may be considered at high risk for future coronary events and may therefore benefit from additional pharmacological treatment.
C1 [Yaylali, Yalin Tolga] Pamukkale Univ, Kardiyol ABD, Dept Cardiol, Fac Med, TR-20070 Denizli, Turkey.
   [Yaylali, Olga] Pamukkale Univ, Fac Med, Dept Nucl Med, TR-20070 Denizli, Turkey.
C3 Pamukkale University; Pamukkale University
RP Yaylali, YT (corresponding author), Pamukkale Univ, Kardiyol ABD, Dept Cardiol, Fac Med, Kalp Merkezi Kin Kampusu, TR-20070 Denizli, Turkey.
EM yaylalimd@gmail.com
RI DURSUNOGLU, DURSUN/LTZ-1214-2024; Yaylali, Yalin/ABI-4603-2020
OI DURSUNOGLU, Prof. Dr. Dursun/0000-0002-5232-7078
CR Arita Y, 2002, CIRCULATION, V105, P2893, DOI 10.1161/01.CIR.0000018622.84402.FF
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NR 32
TC 3
Z9 3
U1 0
U2 3
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0001-5385
EI 1784-973X
J9 ACTA CARDIOL
JI Acta Cardiol.
PD APR
PY 2010
VL 65
IS 2
BP 217
EP 220
DI 10.2143/AC.65.2.2047056
PG 4
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 587XZ
UT WOS:000277031200010
PM 20458830
DA 2025-06-11
ER

PT J
AU Chen, H
   Liu, L
   Li, M
   Zhu, DJ
   Tian, G
AF Chen, Hui
   Liu, Lei
   Li, Min
   Zhu, Danjun
   Tian, Gang
TI Epicardial Adipose Tissue-Derived Leptin Promotes Myocardial Injury in
   Metabolic Syndrome Rats Through PKC/NADPH Oxidase/ROS Pathway
SO JOURNAL OF THE AMERICAN HEART ASSOCIATION
LA English
DT Article
DE epicardial adipose tissue; leptin; metabolic syndrome; myocardial injury
ID MITOCHONDRIAL OXIDATIVE STRESS; PROTEIN-KINASE-C; HEART-FAILURE;
   OBESITY; DYSFUNCTION; FAT; CARDIOMYOCYTES; ACTIVATION; EXPRESSION;
   APOPTOSIS
AB BackgroundThe epicardial adipose tissue (EAT) of metabolic syndrome (MetS) is abnormally accumulated with dysfunctional secretion of adipokines, closely relating to cardiac dysfunction. The current study was designed to identify the effects of EAT-derived leptin on the myocardium of MetS rats and explore the potential molecular mechanisms. Methods and ResultsA MetS rat model was established in 8-week-old Wistar rats by a 12-week high-fat diet. MetS rats exhibited increased leptin secretion from EAT, cardiac hypertrophy, and diastolic dysfunction with preserved systolic function. The myocardium of MetS rats had abnormal structure, increased oxidative stress injury, and higher inflammatory factor levels, especially the subepicardial myocardium, which was correlated with the EAT-derived leptin level but not the serum leptin. The EAT was separated from each group of rats to prepare EAT-conditioned medium. H9C2 rat cardiomyoblasts were treated with EAT-conditioned medium or leptin, plus various inhibitors. EAT-derived leptin from MetS rats promoted mitochondrial oxidative stress and dysfunction, induced mitochondrial pathway apoptosis, and inhibited cell viability in H9C2 cardiomyoblasts via the protein kinase C/reduced nicotinamide adenine dinucleotide phosphate oxidase/reactive oxygen species (PKC/NADPH oxidase/ROS) pathway. EAT-derived leptin from MetS rats stimulated inflammation in H9C2 cardiomyocytes by promoting activator protein 1 nuclear translocation via the PKC/NADPH oxidase/ROS pathway. Leptin promoted the interaction between p-p47(phox) and gp91(phox) in H9C2 cardiomyocytes via protein kinase C, activating nicotinamide adenine dinucleotide phosphate oxidase, increasing reactive oxygen species generation, and inhibiting cell viability. ConclusionsEAT-derived leptin induces MetS-related myocardial injury through the following 2 cooperative ways via PKC/NADPH oxidase/ROS pathway: (1) inducing mitochondrial pathway apoptosis by promoting mitochondrial oxidative stress and dysfunction; and (2) stimulating inflammation by promoting activator protein 1 nuclear translocation.
C1 [Chen, Hui] Zhengzhou Univ, Heart Ctr, Cent China Fuwai Hosp, Henan Prov Peoples Hosp, 1 Fuwai Ave, Zhengzhou 450003, Henan, Peoples R China.
   [Tian, Gang] Xi An Jiao Tong Univ, Dept Cardiol, Affiliated Hosp 1, 277 Yanta West Rd, Xian 710061, Shaanxi, Peoples R China.
   [Chen, Hui] Zhengzhou Univ, Heart Ctr, Cent China Fuwai Hosp, Henan Prov Peoples Hosp, Zhengzhou, Henan, Peoples R China.
   [Liu, Lei; Li, Min; Zhu, Danjun; Tian, Gang] Xi An Jiao Tong Univ, Dept Cardiol, Affiliated Hosp 1, Xian, Shaanxi, Peoples R China.
C3 Zhengzhou University; Xi'an Jiaotong University; Zhengzhou University;
   Xi'an Jiaotong University
RP Chen, H (corresponding author), Zhengzhou Univ, Heart Ctr, Cent China Fuwai Hosp, Henan Prov Peoples Hosp, 1 Fuwai Ave, Zhengzhou 450003, Henan, Peoples R China.; Tian, G (corresponding author), Xi An Jiao Tong Univ, Dept Cardiol, Affiliated Hosp 1, 277 Yanta West Rd, Xian 710061, Shaanxi, Peoples R China.
EM fwhzchenhui@126.com; tiangang@xjtu.edu.cn
OI Chen, Hui/0000-0002-2617-3570
FU Nature Science Foundation of China [81873513, 81600574, 30871042]; Key
   Projects of Shaanxi Science and Technology Research and Development Plan
   [2018ZDXM-SF-049]; Key Project of Clinical Research in the First
   Affiliated Hospital of Xi'an Jiaotong University [XJTU1AF-CRF-2018-005];
   Shaanxi Science and Technology Research and Development Plan of
   International Science and Technology [2012 kw - 40-01, 2014 JM2-8145];
   Joint Construction Project of Henan Medical Science and Technology
   [LHGJ20220103]
FX This study was supported by the Nature Science Foundation of China
   (grant number 81873513, 81600574, and 30871042), Key Projects of Shaanxi
   Science and Technology Research and Development Plan (grant number
   2018ZDXM-SF-049), Key Project of Clinical Research in the First
   Affiliated Hospital of Xi'an Jiaotong University (grant number
   XJTU1AF-CRF-2018-005), Shaanxi Science and Technology Research and
   Development Plan of International Science and Technology (grant number
   2012 kw - 40-01 and 2014 JM2-8145), and the Joint Construction Project
   of Henan Medical Science and Technology (number LHGJ20220103).
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NR 55
TC 7
Z9 8
U1 2
U2 9
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
EI 2047-9980
J9 J AM HEART ASSOC
JI J. Am. Heart Assoc.
PD AUG 1
PY 2023
VL 12
IS 15
DI 10.1161/JAHA.123.029415
PG 30
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA O0UO2
UT WOS:001041061200039
PM 37489731
OA gold
DA 2025-06-11
ER

PT J
AU Seikrit, C
   Lausberg, E
   Buhl, EM
   Gaspar, R
   Tabi, T
   Heffer, M
   Ducza, E
   Sztojkov-Ivanov, A
   Seres, AB
   Szucs, K
   Ivic, V
   Floege, J
   Vari, SG
   Boor, P
   Klinkhammer, BM
AF Seikrit, Claudia
   Lausberg, Eva
   Buhl, Eva Miriam
   Gaspar, Robert
   Tabi, Tamas
   Heffer, Marija
   Ducza, Eszter
   Sztojkov-Ivanov, Anita
   Seres, Adrienn B.
   Szucs, Kalman
   Ivic, Vedrana
   Floege, Juergen
   Vari, Sandor G.
   Boor, Peter
   Klinkhammer, Barbara Mara
TI A Hypercaloric Diet Induces Early Podocyte Damage in Aged, Non-Diabetic
   Rats
SO CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
LA English
DT Article
DE Metabolic syndrome; Podocyte injury; Liraglutide; Metformin; Aging
ID OBESITY-RELATED GLOMERULOPATHY; PARIETAL EPITHELIAL-CELLS; INDEPENDENT
   RISK-FACTOR; METABOLIC SYNDROME; INTERSTITIAL FIBROSIS; LIRAGLUTIDE
   PROTECTS; RENAL INJURY; EXPRESSION; METFORMIN; WEIGHT
AB Background/Aims: The number of patients of older age with metabolic syndrome, obesity, and associated kidney disease, which is characterized by podocyte damage, glomerular hypertrophy, and focal segmental glomerulosclerosis (FSGS), is increasing worldwide. Animal models that would reflect the development of such kidney diseases could facilitate the testing of drugs. We investigated the renal effects of a long-term high caloric diet in aged rats and the potential effects of drugs used to treat metabolic syndrome. Methods: We analyzed ninemonth-old male and female Sprague Dawley rats fed five months with a normal diet (control group) or high-fat-high-carbohydrate diet (HFHCD group). Two additional groups were fed with HFHCD and treated with drugs used in patients with metabolic syndrome, i.e., the glucagon-like peptide receptor 1 agonist liraglutide (HFHCD+liraglutide group) or metformin (HFHCD+metformin group). Results: Except an increase of waist circumference as a sign of visceral obesity, the HFHCD diet did not induce metabolic syndrome or obesity. There were no significant changes in kidney function and all groups showed similar indices of glomerular injury, i.e., no differences in glomerular size or the number of glomeruli with FSGS or with FSGS-precursor lesions quantified by CD44 expression as a marker of parietal epithelial cell (PEC) activation. Analysis of ultrastructural morphology revealed mild podocyte stress and a decrease of glomerular nestin expression in the HFHCD group, whereas podocin and desmin were not altered. HFHCD did not promote fibrogenesis, however, treatment with liraglutide led to a slightly increased tubulointerstitial damage, immune cell infiltration, and collagen IV expression compared to the control and HFHCD groups. Conclusion: A five-month feeding with HFHCD in aged rats induced mild podocyte injury and microinflammation, which was not alleviated by liraglutide or metformin.
   (c) 2021 The Author(s). Published by Cell Physiol Biochem Press GmbH&Co. KG
C1 [Seikrit, Claudia; Floege, Juergen; Boor, Peter] Rhein Westfal TH Aachen, Div Nephrol & Clin Immunol, Aachen, Germany.
   [Seikrit, Claudia; Lausberg, Eva; Buhl, Eva Miriam; Boor, Peter; Klinkhammer, Barbara Mara] Rhein Westfal TH Aachen, Univ Hosp Aachen, Inst Pathol, Pauwelsstr 30, D-52057 Aachen, Germany.
   [Lausberg, Eva] Rhein Westfal TH Aachen, Inst Human Genet, Aachen, Germany.
   [Buhl, Eva Miriam; Boor, Peter] RWTH Aachen Univ Hosp, Electron Microscopy Facil, Aachen, Germany.
   [Gaspar, Robert; Szucs, Kalman] Univ Szeged, Interdisciplinary Excellence Ctr, Dept Pharmacol & Pharmacotherapy, Fac Med, Szeged, Hungary.
   [Tabi, Tamas] Semmelweis Univ, Dept Pharmacodynam, Fac Pharm, Budapest, Hungary.
   [Heffer, Marija; Ivic, Vedrana] JJ Strossmayer Univ Osijek, Dept Med Biol & enet, Fac Med, Osijek, Croatia.
   [Sztojkov-Ivanov, Anita; Seres, Adrienn B.] Univ Szeged, Dept Pharmacodynam & Biopharm, Szeged, Hungary.
   [Vari, Sandor G.] Cedars Sinai Med Ctr, Int Res & Innovat Med Program, Los Angeles, CA 90048 USA.
C3 RWTH Aachen University; RWTH Aachen University; RWTH Aachen University
   Hospital; RWTH Aachen University; RWTH Aachen University; RWTH Aachen
   University Hospital; Szeged University; Semmelweis University;
   University of JJ Strossmayer Osijek; Szeged University; Cedars Sinai
   Medical Center
RP Boor, P (corresponding author), Rhein Westfal TH Aachen, Univ Hosp Aachen, Inst Pathol, Pauwelsstr 30, D-52057 Aachen, Germany.
EM pboor@ukaachen.de
RI Tábi, Tamás/O-2960-2017; Gaspar, Robert/G-7954-2011; Ivić,
   Vedrana/GRS-4202-2022; Klinkhammer, Barbara/AAB-3524-2019; Boor,
   Peter/C-7707-2011; Heffer, Marija/ABA-4694-2020
OI Ivic, Vedrana/0000-0002-8185-1960; Szucs, Kalman
   Ferenc/0000-0002-5878-4691
FU German Research Foundation (DFG) [322900939 - SFB TRR 219, 454024652,
   432698239, 445703531 - CRU 5011 IntraKD]; Federal Ministry of Education
   and Research [STOP-FSGS-01GM1901A]; Medical Faculty of the RWTH Aachen
   [START 109/20]; Association for Regional Cooperation in the Fields of
   Health; Science and Technology (RECOOP HST Association) RECOOP Fusion
   Grant Obesity and Diabetes 2015
FX This study was funded by the German Research Foundation (DFG,
   Project-IDs 322900939 - SFB TRR 219, 454024652, 432698239 to PB; and
   445703531 - CRU 5011 IntraKD to PB and BMK), the Federal Ministry of
   Education and Research (STOP-FSGS-01GM1901A to PB), and by grants from
   the Medical Faculty of the RWTH Aachen (START 109/20 to BMK). This work
   was also supported by the Association for Regional Cooperation in the
   Fields of Health, the Science and Technology (RECOOP HST Association)
   RECOOP Fusion Grant Obesity and Diabetes 2015.
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NR 54
TC 2
Z9 2
U1 0
U2 3
PU Cell Physiol Biochem Press GmbH & Co
PI Dsseldorf
PA Herzogstr. 85, Dsseldorf, GERMANY
SN 1015-8987
EI 1421-9778
J9 CELL PHYSIOL BIOCHEM
JI Cell. Physiol. Biochem.
PY 2021
VL 55
SI 4
BP 96
EP 112
DI 10.33594/000000476
PG 17
WC Cell Biology; Physiology
WE Emerging Sources Citation Index (ESCI)
SC Cell Biology; Physiology
GA VM9EW
UT WOS:001058368500005
PM 34936286
OA Green Accepted, gold
DA 2025-06-11
ER

PT J
AU Berlin, M
   Boyce, CW
AF Berlin, Michael
   Boyce, Christopher W.
TI Recent advances in the development of histamine H3
   antagonists
SO EXPERT OPINION ON THERAPEUTIC PATENTS
LA English
DT Review
DE allergy; CNS disorders; H-3 antagonist; H-3 inverse agonist; H-3
   receptor; histamine; metabolic syndrome; obesity
ID PHARMACOLOGICAL-PROPERTIES; THERAPEUTIC TARGET; RECEPTOR LIGANDS; BRAIN
   HISTAMINE; POTENT; H-3-RECEPTOR; COGNITION; SLEEP; SCHIZOPHRENIA;
   INHIBITION
AB The histamine H-3 receptor is involved in the central and peripheral regulation of levels of histamine and other neurotransmitters (e.g., acetylcholine, noradrenaline, dopamine, serotonin and GABA), which sets it up as a target in the treatment of various CNS (e.g., depression, schizophrenia, ADHD, dementia, neuropathic pain and sleep disorders), metabolic syndrome (e.g., obesity) and allergic disorders. Novel chemical series from the most recent 2 years of patent literature have been reviewed. While overall structural diversity is moderate, these represent or relate to some of the compounds progressing through clinical trials (e.g., GSK-189254). However, an H-3 receptor drug still has yet to reach the market. Patenting activity is likely to remain high in the near future, bolstered by the commercial promise of potential H-3 receptor drugs.
C1 Schering Plough Res Inst, Kenilworth, NJ 07033 USA.
C3 Merck & Company; Schering-Plough Research Institute
RP Berlin, M (corresponding author), Schering Plough Res Inst, 2015 Galloping Hill Rd,K15-1545, Kenilworth, NJ 07033 USA.
EM michael.berlin@spcorp.com
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NR 136
TC 30
Z9 44
U1 1
U2 8
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1354-3776
EI 1744-7674
J9 EXPERT OPIN THER PAT
JI Expert Opin. Ther. Patents
PD JUN
PY 2007
VL 17
IS 6
BP 675
EP 687
DI 10.1517/13543776.17.6.675
PG 13
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 185OI
UT WOS:000247719900007
PM 20144064
DA 2025-06-11
ER

PT J
AU Fernandez, ML
   Thomas, MS
   Lemos, BS
   DiMarco, DM
   Missimer, A
   Melough, M
   Chun, OK
   Murillo, AG
   Alyousef, HM
   Medina-Vera, I
AF Fernandez, Maria Luz
   Thomas, Minu Sara
   Lemos, Bruno S.
   DiMarco, Diana M.
   Missimer, Amanda
   Melough, Melissa
   Chun, Ock K.
   Murillo, Ana Gabriela
   Alyousef, Hana M.
   Medina-Vera, Isabel
TI TA-65, A Telomerase Activator Improves Cardiovascular Markers in
   Patients with Metabolic Syndrome
SO CURRENT PHARMACEUTICAL DESIGN
LA English
DT Article
DE Telomerase activator; metabolic syndrome; inflammation; oxidative
   stress; HDL; Astragalus membranaceus
ID ENDOPLASMIC-RETICULUM STRESS; CARBOHYDRATE RESTRICTION;
   REVERSE-TRANSCRIPTASE; ASTRAGALOSIDE IV; PROTEIN-KINASE;
   CYCLOASTRAGENOL; INFLAMMATION; ATHEROSCLEROSIS; INTERVENTION;
   CHOLESTEROL
AB Background: Telomerase Activator 65 (TA-65), a compound extracted from Astragalus membranaceus has been used in Chinese traditional medicine for extending lifespan. Scarce information exists on the effects of TA-65 on parameters of metabolic syndrome (MetS).
   Methods: We recruited 40 patients with MetS to determine the effects of TA-65 on dyslipidemias, hypertension, and oxidative stress in this at-risk population. The study was a double-blind, randomized crossover design in which patients were allocated to consume either 16 mg daily of a TA-65 supplement or a placebo for 12 weeks. Following a 3-week washout, participants were allocated to the alternate treatment for an additional 12 weeks. Anthropometric and biological markers were measured at the end of each treatment. Plasma lipids, glucose, C-Reactive Protein (CRP), liver enzymes, and glycosylated hemoglobin were measured using a Cobas c-111. Inflammatory cytokines were measured by Luminex technology and markers of oxidative stress by the use of spectroscopy.
   Results: Compared to the placebo period, HDL cholesterol (HDL-C) was higher while body mass index, waist circumference, and the LDL/HDL ratio were lower (p < 0.05) during TA-65 treatment. In addition, plasma tumor necrosis factor-alpha (TNF-alpha) was lower during the TA-65 period (p<0.05). Positive correlations were observed in changes between the placebo and the TA-65 periods in HDL-C and CRP (r = -0.511, p < 0.01), alanine aminotransferase (r = -0.61, p < 0.001) and TNF-alpha (r = -0.550, p < 0.001) suggesting that the favorable changes observed in HDL were associated with decreases in inflammation.
   Conclusion: TA-65 improved key markers of cardiovascular disease risk, which were also associated with reductions in inflammation.
C1 [Fernandez, Maria Luz; Thomas, Minu Sara; Lemos, Bruno S.; DiMarco, Diana M.; Missimer, Amanda; Melough, Melissa; Chun, Ock K.; Murillo, Ana Gabriela; Alyousef, Hana M.; Medina-Vera, Isabel] Univ Connecticut, Dept Nutr Sci, Storrs, CT 06269 USA.
C3 University of Connecticut
RP Fernandez, ML (corresponding author), Univ Connecticut, Dept Nutr Sci, Storrs, CT 06269 USA.
EM maria-luz.fernandez@uconn.edu
RI ; Thomas, Minu Sara/GOH-1463-2022
OI Medina-Vera, Isabel/0000-0003-4027-2329; Thomas, Minu
   Sara/0000-0002-1639-3086; Lemos, Bruno/0000-0002-3859-6175
FU TA Sciences, Inc.
FX The study was supported by a grant from TA Sciences, Inc. awarded to
   MLF. All the other authors do not have a conflict of interest.
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NR 46
TC 30
Z9 32
U1 2
U2 17
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1381-6128
EI 1873-4286
J9 CURR PHARM DESIGN
JI Curr. Pharm. Design
PY 2018
VL 24
IS 17
BP 1905
EP 1911
DI 10.2174/1381612824666180316114832
PG 7
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA GP7MF
UT WOS:000441084200012
PM 29546832
DA 2025-06-11
ER

PT J
AU Fredman, L
   Doros, G
   Cauley, JA
   Hillier, TA
   Hochberg, MC
AF Fredman, Lisa
   Doros, Gheorghe
   Cauley, Jane A.
   Hillier, Teresa A.
   Hochberg, Marc C.
TI Caregiving, Metabolic Syndrome Indicators, and 1-year Decline in Walking
   Speed: Results of Caregiver-SOF
SO JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL
   SCIENCES
LA English
DT Article
DE Caregiving; Dementia caregivers; Metabolic indicators; Gait speed
ID PITUITARY-ADRENAL AXIS; CORONARY-HEART-DISEASE; CHRONIC STRESS; MOBILITY
   LIMITATION; BODY-COMPOSITION; OLDER-ADULTS; HEALTH; DEMENTIA; WOMEN;
   PREDICTS
AB Background. Chronic stress may lead to health decline through metabolic syndrome. Thus, persons in stressful care-giving situations who also have more indicators of metabolic syndrome may experience more decline than other caregivers or noncaregivers.
   Methods. The sample included 921 women (338 caregivers and 583 noncaregivers) from the Caregiver-Study of Osteoporotic Fractures study. Participants had home-based baseline and I-year follow-up interviews between 1999 and 2003. At baseline, caregivers were categorized as long term (>= 4 years) versus short term (<4 years), and caring for someone with Alzheimer's disease/dementia or not. A metabolic risk composite score was the sum of four indicators: body mass index >= 30, and diagnosis or using medications for hypertension, diabetes, or high cholesterol. Walking speed (m/second) was measured at both interviews.
   Results. Walking speed declined for the total sample (adjusted mean = -0.005 m/second, +/- 0.16) over an average of 1.04 years (+/- 0.16). Overall, caregiving was not associated with decline. Increasing metabolic risk score was associated with greater decline for the total sample and long-term and dementia caregivers, but not other caregivers or noncaregivers. Metabolic risk score modified the adjusted associations between years of caregiving and dementia caregiving with walking speed decline (p values for interaction terms were 0.039 and 0.057, respectively). The biggest declines were in long-term caregivers and dementia caregivers who also had 3-4 metabolic indicators (-0.10 m/second and 0.155 m/second, respectively).
   Conclusions. Walking speed declined the most among older women who had both stressful caregiving situations and more metabolic syndrome indicators, suggesting these caregiver subgroups may have increased risk of health decline.
C1 [Fredman, Lisa] Boston Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02118 USA.
   [Doros, Gheorghe] Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02118 USA.
   [Cauley, Jane A.] Univ Pittsburgh, Dept Epidemiol, Grad Sch Publ Hlth, Pittsburgh, PA 15260 USA.
   [Hillier, Teresa A.] Kaiser Permanente Ctr Hlth Res NW Hawaii, Portland, OR USA.
   [Hochberg, Marc C.] Univ Maryland, Sch Med, Dept Med, Baltimore, MD 21201 USA.
   [Hochberg, Marc C.] Univ Maryland, Sch Med, Dept Epidemiol & Prevent Med, Baltimore, MD 21201 USA.
C3 Boston University; Boston University; Pennsylvania Commonwealth System
   of Higher Education (PCSHE); University of Pittsburgh; Kaiser
   Permanente; University System of Maryland; University of Maryland
   Baltimore; University System of Maryland; University of Maryland
   Baltimore
RP Fredman, L (corresponding author), Boston Univ, Sch Publ Hlth, Dept Epidemiol, 715 Albany St, Boston, MA 02118 USA.
EM lfredman@bu.edu
RI Cauley, Jane/N-4836-2015
OI , Gheorghe/0000-0001-5524-4721; Cauley, Jane A/0000-0003-0752-4408;
   Fredman, Lisa/0000-0001-5341-2955
FU NIAMS NIH HHS [AR35583, AR35584, AR35582] Funding Source: Medline; NIA
   NIH HHS [R01 AG018037, AG05407, AG18037, AG05394] Funding Source:
   Medline
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NR 40
TC 28
Z9 32
U1 0
U2 5
PU GERONTOLOGICAL SOC AMER
PI WASHINGTON
PA 1030 15TH ST NW, STE 250, WASHINGTON, DC 20005202-842 USA
SN 1079-5006
J9 J GERONTOL A-BIOL
JI J. Gerontol. Ser. A-Biol. Sci. Med. Sci.
PD MAY
PY 2010
VL 65
IS 5
BP 565
EP 572
DI 10.1093/gerona/glq025
PG 8
WC Geriatrics & Gerontology; Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA 589BY
UT WOS:000277120700017
PM 20351074
OA Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Confettura, AD
   Cuboni, E
   Ammar, MR
   Jia, S
   Gomes, GM
   Yuanxiang, P
   Raman, R
   Li, TT
   Grochowska, KM
   Ahrends, R
   Karpova, A
   Dityatev, A
   Kreutz, MR
AF Confettura, Alessandro Dario
   Cuboni, Eleonora
   Ammar, Mohamed Rafeet
   Jia, Shaobo
   Gomes, Guilherme M.
   Yuanxiang, PingAn
   Raman, Rajeev
   Li, Tingting
   Grochowska, Katarzyna M.
   Ahrends, Robert
   Karpova, Anna
   Dityatev, Alexander
   Kreutz, Michael R.
TI Neddylation-dependent protein degradation is a nexus between synaptic
   insulin resistance, neuroinflammation and Alzheimer's disease
SO TRANSLATIONAL NEURODEGENERATION
LA English
DT Article
DE Metabolic syndrome; Alzheimer's disease; Neddylation; Cullins; MLN-4924;
   Insulin; IRS1; Amyloid-beta; TNF alpha
ID BETA-AMYLOID OLIGOMERS; LONG-TERM DEPRESSION; RECEPTOR SUBSTRATE 1;
   DIABETES-MELLITUS; NEDD8-ACTIVATING ENZYME; METABOLIC SYNDROME; A-BETA;
   BRAIN; MICE; HYPOTHESIS
AB Background: The metabolic syndrome is a consequence of modern lifestyle that causes synaptic insulin resistance and cognitive deficits and that in interaction with a high amyloid load is an important risk factor for Alzheimer's disease. It has been proposed that neuroinflammation might be an intervening variable, but the underlying mechanisms are currently unknown.
   Methods: We utilized primary neurons to induce synaptic insulin resistance as well as a mouse model of high-risk aging that includes a high amyloid load, neuroinflammation, and diet-induced obesity to test hypotheses on underlying mechanisms.
   Results: We found that neddylation and subsequent activation of cullin-RING ligase complexes induced synaptic insulin resistance through ubiquitylation and degradation of the insulin-receptor substrate IRS1 that organizes synaptic insulin signaling. Accordingly, inhibition of neddylation preserved synaptic insulin signaling and rescued memory deficits in mice with a high amyloid load, which were fed with a 'western diet'.
   Conclusions: Collectively, the data suggest that neddylation and degradation of the insulin-receptor substrate is a nodal point that links high amyloid load, neuroinflammation, and synaptic insulin resistance to cognitive decline and impaired synaptic plasticity in high-risk aging.
C1 [Confettura, Alessandro Dario; Cuboni, Eleonora; Ammar, Mohamed Rafeet; Gomes, Guilherme M.; Yuanxiang, PingAn; Raman, Rajeev; Grochowska, Katarzyna M.; Karpova, Anna; Kreutz, Michael R.] Leibniz Inst Neurobiol, RG Neuroplast, D-39118 Magdeburg, Germany.
   [Jia, Shaobo; Dityatev, Alexander; Kreutz, Michael R.] German Ctr Neurodegenerat Dis DZNE, D-39120 Magdeburg, Germany.
   [Gomes, Guilherme M.; Karpova, Anna; Dityatev, Alexander; Kreutz, Michael R.] Otto Guericke Univ, Ctr Behav Brain Sci, D-39120 Magdeburg, Germany.
   [Li, Tingting; Ahrends, Robert] Leibniz Inst Analytische Wissenschaften ISASeV, D-44227 Dortmund, Germany.
   [Grochowska, Katarzyna M.; Kreutz, Michael R.] Univ Med Ctr Hamburg Eppendorf, ZMNH, Ctr Mol Neurobiol, Leibniz Grp Dendrit Organelles & Synapt Funct, D-20251 Hamburg, Germany.
   [Ahrends, Robert] Univ Vienna, Fac Chem, Dept Analyt Chem, A-1090 Vienna, Austria.
   [Dityatev, Alexander] Otto von Guericke Univ, Fac Med, D-39120 Magdeburg, Germany.
C3 Leibniz Association; Leibniz Institut fur Neurobiologie (LIN); Helmholtz
   Association; German Center for Neurodegenerative Diseases (DZNE); Otto
   von Guericke University; Dortmund University of Technology; Leibniz
   Association; Leibniz Institut fur Analytische Wissenschaften (ISAS);
   University of Hamburg; University Medical Center Hamburg-Eppendorf;
   University of Vienna; Otto von Guericke University
RP Kreutz, MR (corresponding author), Leibniz Inst Neurobiol, RG Neuroplast, D-39118 Magdeburg, Germany.; Kreutz, MR (corresponding author), German Ctr Neurodegenerat Dis DZNE, D-39120 Magdeburg, Germany.; Kreutz, MR (corresponding author), Otto Guericke Univ, Ctr Behav Brain Sci, D-39120 Magdeburg, Germany.; Kreutz, MR (corresponding author), Univ Med Ctr Hamburg Eppendorf, ZMNH, Ctr Mol Neurobiol, Leibniz Grp Dendrit Organelles & Synapt Funct, D-20251 Hamburg, Germany.
EM michael.kreutz@lin-magdeburg.de
RI Ahrends, Robert/ISS-2350-2023; YUANXIANG, PingAn/AAF-1662-2019;
   Dityatev, Alexander/A-4034-2008; Grochowska, Katarzyna/H-7879-2016
OI YUANXIANG, PingAn/0000-0002-3746-3282; Grochowska,
   Katarzyna/0000-0001-8298-176X; Dityatev, Alexander/0000-0002-0472-0553;
   Monteiro Gomes, Guilherme/0000-0001-8566-4284
FU Projekt DEAL; Deutsche Forschungsgemeinschaft (DFG) [Kr 1879/9-1/FOR
   2419, Kr1879/5-1/6-1/10-1, CRC1436, 425899996, 2413]; BMBF ['Energi'FKZ:
   01GQ1421B, 'Energi' FKZ: 01GQ1421A]; EU Joint
   Programme-Neurodegenerative Disease Research (JPND) project STAD
   [01ED1613]; Leibniz Foundation; Alexander-von-Humboldt Foundation/CAPES
   post-doctoral research fellowship [99999.001756/2014-01]
FX Open Access funding enabled and organized by Projekt DEAL. Supported by
   Grants from the Deutsche Forschungsgemeinschaft (DFG) (Kr 1879/9-1/FOR
   2419, Kr1879/5-1/6-1/10-1; CRC1436 A02 Project-ID 425899996; Research
   Training Group 2413 SynAGE, TP4), BMBF 'Energi'FKZ: 01GQ1421B, The EU
   Joint Programme--Neurodegenerative Disease Research (JPND) project STAD
   (01ED1613) and Leibniz Foundation SAW 'ISAS2', 'SynMetAge',
   Neurotranslation' and 'SynErca' to MRK.; CRC1436 A02 Project-ID
   425899996 to AK; CRC1436 A05 Project-ID 425899996, Research Training
   Group 2413 SynAGE TP5 and BMBF `Energi' FKZ: 01GQ1421A to AD. G.M.G. was
   supported by the Alexander-von-Humboldt Foundation/CAPES post-doctoral
   research fellowship (99999.001756/2014-01).
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NR 72
TC 14
Z9 16
U1 6
U2 17
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 2047-9158
J9 TRANSL NEURODEGENER
JI Transl. Neurodegener.
PD JAN 6
PY 2022
VL 11
IS 1
AR 2
DI 10.1186/s40035-021-00277-8
PG 18
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA YC0NM
UT WOS:000739397000001
PM 34986876
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Gibson, M
   Carek, PJ
   Sullivan, B
AF Gibson, Maria
   Carek, Peter J.
   Sullivan, Brigid
TI TREATMENT OF CO-MORBID MENTAL ILLNESS IN PRIMARY CARE: HOW TO MINIMIZE
   WEIGHT GAIN, DIABETES, AND METABOLIC SYNDROME
SO INTERNATIONAL JOURNAL OF PSYCHIATRY IN MEDICINE
LA English
DT Article
DE mental illness; metabolic risk; obesity; metabolic syndrome; diabetes
ID BODY-WEIGHT; BIPOLAR-DISORDER; DOUBLE-BLIND; DEPRESSION; SCHIZOPHRENIA;
   METFORMIN; THERAPY; ADULTS; ANTIPSYCHOTICS; LAMOTRIGINE
AB In patients with mental illness the increased risk from cardiovascular disease appears to be related to the increased incidence of obesity, hypertension, and diabetes mellitus. Barriers to the medical care in this patient population include diminished adherence to treatment and preventative recommendations, lack of willingness to engage in self-care activities, decreased access to affordable medical care, underestimation of risk by physicians, and adverse effects of commonly prescribed psychiatric medications. When managing patients with mental illness it is necessary to estimate the patient's metabolic and cardiovascular risk, monitor BMI, waist circumference, fasting glucose, and lipid profile regularly, evaluate psychiatric medications metabolic risk, and choose less "metabolically threatening" drugs. The promotion of healthy lifestyle choices among persons with serious mental illness is essential not only as part of their recovery, but as an integral part of preventing metabolic changes and weight gain linked to their illness and medication side effects. In patients with mental illness and co-morbid diabetes, metabolic syndrome, and obesity, psychiatrist and primary care clinicians should collaborate to establish a plan for healthy lifestyle habits (diet and activity regimen), encourage weight loss, and follow-up regularly using multispecialty teams to improve management. (Int'l. J. Psychiatry in Medicine 201141:127-142)
C1 [Gibson, Maria; Carek, Peter J.; Sullivan, Brigid] Med Univ S Carolina, Charleston, SC 29425 USA.
C3 Medical University of South Carolina
RP Gibson, M (corresponding author), 9228 Med Plaza Dr, Charleston, SC 29406 USA.
EM gibsonmv@musc.edu
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NR 64
TC 14
Z9 18
U1 0
U2 19
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0091-2174
EI 1541-3527
J9 INT J PSYCHIAT MED
JI Int. J. Psychiatr. Med.
PY 2011
VL 41
IS 2
BP 127
EP 142
DI 10.2190/PM.41.2.c
PG 16
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 764NS
UT WOS:000290638200003
PM 21675345
DA 2025-06-11
ER

PT J
AU Buscemi, S
   Re, A
   Batsis, JA
   Arnone, M
   Mattina, A
   Cerasola, G
   Verga, S
AF Buscemi, S.
   Re, A.
   Batsis, J. A.
   Arnone, M.
   Mattina, A.
   Cerasola, G.
   Verga, S.
TI Glycaemic variability using continuous glucose monitoring and
   endothelial function in the metabolic syndrome and in Type 2 diabetes
SO DIABETIC MEDICINE
LA English
DT Article
DE diabetes; endothelial function; glycaemic variability; intima-media
   thickness; metabolic syndrome
ID INTIMA-MEDIA THICKNESS; CARDIOVASCULAR-DISEASE; MYOCARDIAL-INFARCTION;
   MONOCYTE ADHESION; OXIDATIVE STRESS; RISK; HYPERGLYCEMIA; FLUCTUATIONS;
   INDIVIDUALS; ULTRASOUND
AB P>Aims
   Subjects who are at increased risk of developing diabetes may have increased glycaemic variability associated with endothelial dysfunction and possibly subclinical atherosclerosis, which may lead to increased cardiovascular risk observed at the time of diabetes diagnosis. To investigate this hypothesis, we measured endothelial function, carotid intima-media thickness and glycaemic variability using 48-h continuous subcutaneous glucose monitoring in 3 groups of overweight or obese subjects - those without the metabolic syndrome, and those with the metabolic syndrome with or without newly diagnosed Type 2 diabetes.
   Methods
   Consecutive subjects, aged 30-65 years with a body mass index >= 25 kg/m2 were recruited. Patients were classified as with or without the metabolic syndrome,or as metabolic syndrome with newly diagnosed Type 2 DM. Glycaemic variability was calculated in terms of the coefficient of variation. Endothelial function was measured using brachial artery flow-mediated dilation.
   Results
   We identified 75 subjects. Mean flow mediated dilation decreased (P < 0.001) and carotid intima-media thickness increased (P < 0.05) across groups. Flow mediated dilation predictors included mean 48-h continuous subcutaneous glucose monitoring values (beta = -0.022; P < 0.005) and the coefficient of variation (beta = -0.10; P = 0.01). Carotid intima-media thickness predictors included age (beta = 0.009; P < 0.001) and flow mediated dilation (beta = -0.014; P = 0.076). Patients re-stratified according to cut-offs for mean 48-h glycaemia and variability demonstrated that subjects with high mean glycaemia but low coefficient of variability had similar flow mediated dilation and carotid intima-media thickness to subjects with low mean glycaemia but high coefficient of variation.
   Conclusions
   This study suggests that glycaemic variability influences endothelial function even in non-diabetic subjects. Such variability may explain the increased cardiovascular risk observed in patients prior to developing overt Type 2 diabetes.
C1 [Buscemi, S.; Re, A.; Arnone, M.; Mattina, A.; Cerasola, G.; Verga, S.] Univ Palermo, Fac Med, Dipartimento Med Interna Malattie Cardiovasc & Ne, Palermo, Italy.
   [Batsis, J. A.] Dartmouth Hitchcock Med Ctr, Gen Internal Med Sect, Lebanon, NH USA.
   [Batsis, J. A.] Dartmouth Coll, Hanover, NH 03755 USA.
C3 University of Palermo; Dartmouth College; Dartmouth College
RP Buscemi, S (corresponding author), Med Interna Nefrol & Ipertens Policlin P Giaccone, Via Vespro 129, I-90127 Palermo, Italy.
EM silbus@tin.it
RI Batsis, John/AAC-7185-2019; buscemi, silvio/K-9662-2016; Mattina,
   Alessandro/F-6020-2019
OI VERGA, Salvatore/0000-0002-7743-7847; buscemi,
   silvio/0000-0003-0730-7649; Mattina, Alessandro/0000-0003-3458-0894
FU Italian Ministry of Education; Associazione Onlus Nutrizione e Salute,
   Italy
FX This study was supported by the Italian Ministry of Education (ex 60%
   funds, project 2006) and by the Associazione Onlus Nutrizione e Salute,
   Italy.
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NR 38
TC 65
Z9 75
U1 0
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0742-3071
EI 1464-5491
J9 DIABETIC MED
JI Diabetic Med.
PD AUG
PY 2010
VL 27
IS 8
BP 872
EP 878
DI 10.1111/j.1464-5491.2010.03059.x
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 626RN
UT WOS:000279984700005
PM 20653743
DA 2025-06-11
ER

PT J
AU Kankaanranta, H
   Kauppi, P
   Tuomisto, LE
   Ilmarinen, P
AF Kankaanranta, Hannu
   Kauppi, Paula
   Tuomisto, Leena E.
   Ilmarinen, Pinja
TI Emerging Comorbidities in Adult Asthma: Risks, Clinical Associations,
   and Mechanisms
SO MEDIATORS OF INFLAMMATION
LA English
DT Review
ID QUALITY-OF-LIFE; OBSTRUCTIVE PULMONARY-DISEASE; MORBIDLY OBESE SUBJECTS;
   CORONARY-HEART-DISEASE; IMPAIRED LUNG-FUNCTION; BODY-MASS INDEX; ONSET
   ASTHMA; CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; ASYMMETRIC
   DIMETHYLARGININE
AB Asthma is a heterogeneous disease with many phenotypes, and age at disease onset is an important factor in separating the phenotypes. Most studies with asthma have been performed in patients being otherwise healthy. However, in real life, comorbid diseases are very common in adult patients. We review here the emerging comorbid conditions to asthma such as obesity, metabolic syndrome, diabetes mellitus type 2 (DM2), and cardiac and psychiatric diseases. Their role as risk factors for incident asthma and whether they affect clinical asthma are evaluated. Obesity, independently or as a part of metabolic syndrome, DM2, and depression are risk factors for incident asthma. In contrast, the effects of comorbidities on clinical asthma are less well-known and mostly studies are lacking. Cross-sectional studies in obese asthmatics suggest that they may have less well controlled asthma and worse lung function. However, no long-term clinical follow-up studies with these comorbidities and asthma were identified. These emerging comorbidities often occur in the same multimorbid adult patient and may have in common metabolic pathways and inflammatory or other alterations such as early life exposures, systemic inflammation, inflammasome, adipokines, hyperglycemia, hyperinsulinemia, lung mechanics, mitochondrial dysfunction, disturbed nitric oxide metabolism, and leukotrienes.
C1 [Kankaanranta, Hannu; Tuomisto, Leena E.; Ilmarinen, Pinja] Seinajoki Cent Hosp, Dept Resp Med, Seinajoki 60220, Finland.
   [Kankaanranta, Hannu] Univ Tampere, Dept Resp Med, Tampere 33521, Finland.
   [Kauppi, Paula] Helsinki Univ Hosp, Skin & Allergy Hosp, Dept Resp Med & Allergol, Helsinki 00029, Finland.
   [Kauppi, Paula] Univ Helsinki, Helsinki 00029, Finland.
C3 Seinajoki Central Hospital; Tampere University; University of Helsinki;
   Helsinki University Central Hospital; University of Helsinki
RP Kankaanranta, H (corresponding author), Seinajoki Cent Hosp, Dept Resp Med, Seinajoki 60220, Finland.; Kankaanranta, H (corresponding author), Univ Tampere, Dept Resp Med, Tampere 33521, Finland.
EM hannu.kankaanranta@epshp.fi
RI Kauppi, Paula/AAX-9525-2020
OI Ilmarinen, Pinja/0000-0002-8758-2431; Kauppi, Paula/0000-0002-1065-330X
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NR 217
TC 81
Z9 81
U1 0
U2 21
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 0962-9351
EI 1466-1861
J9 MEDIAT INFLAMM
JI Mediat. Inflamm.
PY 2016
VL 2016
AR 3690628
DI 10.1155/2016/3690628
PG 23
WC Cell Biology; Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Immunology
GA DL3UB
UT WOS:000375557800001
PM 27212806
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Silva, AMDE
   Pereira, RO
   Oliveira, AKD
   Harris, FS
   de Melo, ILP
   Almeida-Souza, TH
   Yoshime, LT
   Melo, CD
   dos Santos, JL
   de Andrade-Wartha, ERS
   Cogliati, B
   Granato, D
   Mancini, J
AF de Oliveira e Silva, Ana Mara
   Pereira, Raquel Oliveira
   Oliveira, Anne Karoline de Souza
   Harris, Fernanda Santana
   de Melo, Illana Louise Pereira
   Almeida-Souza, Thiago Henrique
   Yoshime, Luciana Tedesco
   Melo, Caroline dos Santos
   dos Santos, Jymmys Lopes
   de Andrade-Wartha, Elma Regina Silva
   Cogliati, Bruno
   Granato, Daniel
   Mancini-Filho, Jorge
TI Ameliorative effects of aqueous extract from rosemary on oxidative
   stress and inflammation pathways caused by a high-fat diet in C57BL/6
   mice
SO APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
LA English
DT Article
DE obesity; metabolic syndrome; rosemary; phenolic compounds; oxidative
   stress; inflammation
ID ROSMARINUS-OFFICINALIS L.; CARNOSIC ACID; ADIPOCYTE DIFFERENTIATION;
   ANTIOXIDANT ACTIVITY; METABOLIC SYNDROME; LIPID-METABOLISM;
   ACCUMULATION; ACTIVATION; STEATOSIS; TISSUES
AB Rosemary is an herb exhibits biological properties, attenuates inflammation, oxidative stress, and improves lipid profile. Here, we evaluated the effects of rosemary aqueous extract (RE) on mice fed with a high-fat diet (HFD). Male C57BL/6 mice were administered a control diet or HFD for 10 weeks. The treated groups received RE in the diet at different concentrations: 25, 250, and 500 mg/100 g. After 10 weeks, serum concentrations of glucose, lipid, insulin, leptin, adiponectin, and cytokines were evaluated and the oxygen radical absorbance capacity was determined. Histological analysis was performed to determine the concentrations of triacylglycerides (TG), total cholesterol, cytokines, and antioxidant enzymes as well as the expression of genes involved in lipid metabolism, oxidative stress, and inflammation. The dietary RE ameliorated HFD-induced weight gain, adipose tissue weight, glucose intolerance, and insulin, leptin, and free fatty acid levels. Reduction in hepatic TG deposition was observed. The levels of inflammatory cytokines decreased, and the expression of genes involved in lipid metabolism increased. RE mitigated oxidative stress and reduced the production of reactive oxygen species in HepG2 and 3T3-L1 cells. Therefore, RE is a potential therapeutic agent for the prevention of inflammation and oxidative stress outcomes associated with obesity.
C1 [de Oliveira e Silva, Ana Mara; Almeida-Souza, Thiago Henrique; Melo, Caroline dos Santos; de Andrade-Wartha, Elma Regina Silva] Fed Univ Sergipe UFS, Nutr Sci Grad Program, Sao Cristovao, Sergipe, Brazil.
   [de Oliveira e Silva, Ana Mara; Pereira, Raquel Oliveira; Oliveira, Anne Karoline de Souza] Fed Univ Sergipe UFS, Hlth Sci Grad Program, Aracaju, Sergipe, Brazil.
   [Harris, Fernanda Santana; de Melo, Illana Louise Pereira; Yoshime, Luciana Tedesco; Mancini-Filho, Jorge] Univ Sao Paulo, Fac Pharmaceut Sci, Dept Food & Expt Nutr, Lab Lipids, Sao Paulo, SP, Brazil.
   [dos Santos, Jymmys Lopes] Fed Univ Sergipe UFS, Dept Morphol, Sao Cristovao, Sergipe, Brazil.
   [Cogliati, Bruno] Univ Sao Paulo, Sch Vet Med & Anim Sci, Dept Pathol, Sao Paulo, SP, Brazil.
   [Granato, Daniel] Univ Limerick, Fac Sci & Engn, Dept Biol Sci, Limerick V94 T9PX, Ireland.
C3 Universidade de Sao Paulo; Universidade de Sao Paulo; University of
   Limerick
RP Silva, AMDE (corresponding author), Fed Univ Sergipe UFS, Nutr Sci Grad Program, Sao Cristovao, Sergipe, Brazil.; Silva, AMDE (corresponding author), Fed Univ Sergipe UFS, Hlth Sci Grad Program, Aracaju, Sergipe, Brazil.
EM anamaraufs@gmail.com
RI Melo, Caroline/KIJ-1794-2024; Granato, Daniel/AAC-6151-2019; Yoshime,
   Luciana/L-5705-2015; Cogliati, Bruno/E-9956-2012
OI Granato, Daniel/0000-0002-4533-1597; Almeida-Souza, Thiago
   Henrique/0000-0001-8977-9337; Silva, Ana/0000-0003-0831-8833
FU National Council of Technological and Scientific Development (CNPq,
   Brazil) [487122/2013-5]; National Council for the Improvement of Higher
   Education (CAPES, Brazil)
FX The authors would like to thank the National Council of Technological
   and Scientific Development (CNPq, Brazil) for funding this project
   (grant number 487122/2013-5) . This research also was supported by
   grants from National Council for the Improvement of Higher Education
   (CAPES, Brazil) .
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NR 66
TC 3
Z9 3
U1 1
U2 15
PU CANADIAN SCIENCE PUBLISHING
PI OTTAWA
PA 123 Slater Street, Suite 610, OTTAWA, ON K1P 5H2, CANADA
SN 1715-5312
EI 1715-5320
J9 APPL PHYSIOL NUTR ME
JI Appl. Physiol. Nutr. Metab.
PD APR
PY 2024
VL 49
IS 4
BP 459
EP 472
DI 10.1139/apnm-2023-0157459
PG 14
WC Nutrition & Dietetics; Physiology; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics; Physiology; Sport Sciences
GA MS9R2
UT WOS:001195747100001
PM 38048548
DA 2025-06-11
ER

PT J
AU Eyvazlou, M
   Hosseinpouri, M
   Mokarami, H
   Gharibi, V
   Jahangiri, M
   Cousins, R
   Nikbakht, HA
   Barkhordari, A
AF Eyvazlou, Meysam
   Hosseinpouri, Mahdi
   Mokarami, Hamidreza
   Gharibi, Vahid
   Jahangiri, Mehdi
   Cousins, Rosanna
   Nikbakht, Hossein-Ali
   Barkhordari, Abdullah
TI Prediction of metabolic syndrome based on sleep and work-related risk
   factors using an artificial neural network
SO BMC ENDOCRINE DISORDERS
LA English
DT Article
DE Metabolic syndrome; Work-related stressors; Obstructive sleep apnea;
   Workplace; Modelling
ID SHIFT WORK; MANAGEMENT STANDARDS; STRESS; PREVALENCE; INDEX; TOOL; UK
AB Background Metabolic syndrome (MetS) is a major public health concern due to its high prevalence and association with heart disease and diabetes. Artificial neural networks (ANN) are emerging as a reliable means of modelling relationships towards understanding complex illness situations such as MetS. Using ANN, this research sought to clarify predictors of metabolic syndrome (MetS) in a working age population. Methods Four hundred sixty-eight employees of an oil refinery in Iran consented to providing anthropometric and biochemical measurements, and survey data pertaining to lifestyle, work-related stressors and sleep variables. National Cholesterol Education Programme Adult Treatment Panel CYRILLIC CAPITAL LETTER BYELORUSSIAN-UKRAINIAN ICYRILLIC CAPITAL LETTER BYELORUSSIAN-UKRAINIAN II criteria was used for determining MetS status. The Management Standards Indicator Tool and STOP-BANG questionnaire were used to measure work-related stress and obstructive sleep apnoea respectively. With 17 input variables, multilayer perceptron was used to develop ANNs in 16 rounds of learning. ANNs were compared to logistic regression models using the mean squared error criterion for validation. Results Sex, age, exercise habit, smoking, high risk of obstructive sleep apnoea, and work-related stressors, particularly Role, all significantly affected the odds of MetS, but shiftworking did not. Prediction accuracy for an ANN using two hidden layers and all available input variables was 89%, compared to 72% for the logistic regression model. Sensitivity was 82.5% for ANN compared to 67.5% for the logistic regression, while specificities were 92.2 and 74% respectively. Conclusions Our analyses indicate that ANN models which include psychosocial stressors and sleep variables as well as biomedical and clinical variables perform well in predicting MetS. The findings can be helpful in designing preventative strategies to reduce the cost of healthcare associated with MetS in the workplace.
C1 [Eyvazlou, Meysam] Univ Tehran Med Sci, Sch Publ Hlth, Dept Occupat Hlth Engn, Tehran, Iran.
   [Hosseinpouri, Mahdi] Ctr Planning Budgeting & Performance Evaluat, Dept Environm, Shiraz, Iran.
   [Mokarami, Hamidreza] Shiraz Univ Med Sci, Sch Publ Hlth, Dept Ergon, Shiraz, Iran.
   [Gharibi, Vahid; Jahangiri, Mehdi] Shiraz Univ Med Sci, Sch Hlth, Dept Occupat Hlth, Shiraz, Iran.
   [Cousins, Rosanna] Liverpool Hope Univ, Dept Psychol, Liverpool, Merseyside, England.
   [Nikbakht, Hossein-Ali] Babol Univ Med Sci, Fac Med, Dept Biostat & Epidemiol, Social Determinants Hlth Res Ctr,Hlth Res Inst, Babol, Iran.
   [Barkhordari, Abdullah] Shahroud Univ Med Sci, Sch Publ Hlth, Dept Occupat Hlth, Shahroud, Iran.
C3 Tehran University of Medical Sciences; Shiraz University of Medical
   Science; Shiraz University of Medical Science; Liverpool Hope
   University; University of Liverpool; Babol University of Medical
   Sciences; Shahroud University Medical Sciences
RP Gharibi, V (corresponding author), Shiraz Univ Med Sci, Sch Hlth, Dept Occupat Hlth, Shiraz, Iran.; Cousins, R (corresponding author), Liverpool Hope Univ, Dept Psychol, Liverpool, Merseyside, England.
EM gharibi@sums.ac.ir; cousinr@hope.ac.uk
RI hosseinpouri/W-2894-2019; Barkhordari, Abdullah/P-4086-2018; nikbakht,
   hossein-ali/F-2436-2018; Eyvazlou, Meysam/AIF-1612-2022; Gharibi,
   Vahid/Q-6954-2018; Cousins, Rosanna/H-6358-2019; Jahangiri,
   Mehdi/F-2541-2014; mokarami, hamidreza/O-4153-2017
OI Cousins, Rosanna/0000-0003-4829-5138; Jahangiri,
   Mehdi/0000-0002-4703-2523; gharibi, vahid/0000-0002-9974-3060; Nikbakht,
   Hossein-Ali/0000-0002-8556-431X; mokarami, hamidreza/0000-0003-1085-749X
FU Shiraz University of Medical Sciences
FX This study was supported by travel grants from Shiraz University of
   Medical Sciences.
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NR 44
TC 16
Z9 16
U1 0
U2 3
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1472-6823
J9 BMC ENDOCR DISORD
JI BMC Endocr. Disord.
PD NOV 12
PY 2020
VL 20
IS 1
AR 169
DI 10.1186/s12902-020-00645-x
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism
GA OT4UF
UT WOS:000590842500002
PM 33183282
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Hermans, N
   Van der Auwera, A
   Breynaert, A
   Verlaet, A
   De Bruyne, T
   Van Gaal, L
   Pieters, L
   Verhoeven, V
AF Hermans, Nina
   Van der Auwera, Anastasia
   Breynaert, Annelies
   Verlaet, Annelies
   De Bruyne, Tess
   Van Gaal, Luc
   Pieters, Luc
   Verhoeven, Veronique
TI A red yeast rice-olive extract supplement reduces biomarkers of
   oxidative stress, OxLDL and Lp-PLA2, in subjects with
   metabolic syndrome: a randomised, double-blind, placebo-controlled trial
SO TRIALS
LA English
DT Article
DE Metabolic syndrome; Red yeast rice; Olive; Oxidative stress
ID LOW-DENSITY-LIPOPROTEIN; RISK-FACTORS; LIPID-PEROXIDATION;
   MONASCUS-PURPUREUS; PHENOLIC-COMPOUNDS; OXIDIZED LDL; OIL; ASSOCIATION;
   ANTIOXIDANT; EFFICACY
AB Background: Metabolic syndrome (MetS) refers to clustered cardiovascular risk factors (abdominal obesity, pre-diabetes, high blood pressure, dyslipidaemia). Therapies targeting oxidative stress may delay progression to atherosclerosis and diabetes. We investigated the anti-oxidative effect of a supplement combining red yeast rice and olive extract in patients with MetS.
   Methods: A double-blind, placebo-controlled, randomised trial was conducted with 50 patients with MetS as defined by National Cholesterol Education Program Adult Treatment Panel III criteria. Forty-nine subjects randomly assigned to red yeast rice-olive extract (RYR-olive extract; 10.82 mg of monacolins and 9.32 mg of hydroxytyrosol per Cholesfytolplus capsule) or placebo completed the 8-week trial. Whereas effects on cardiovascular risk parameters of MetS have been reported recently, the observed significant 20% increase in oxidised low-density lipoprotein (OxLDL) prompted us to investigate other oxidative stress-related parameters: malondialdehyde (MDA), lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) and 8-hydroxy-2'-deoxyguanosine (8-OHdG). Statistical calculations included univariate quantitative analysis, multivariate linear regression and correlation analysis.
   Results: The updated results indicate that an RYR-olive extract supplement significantly reduced Lp-PLA(2) by 7% (p < 0.001), but it failed to show a significant decrease in plasma MDA and 8-OHdG (p > 0.05). Reductions in OxLDL (20%) and Lp-PLA(2) (7%) were associated with each other (r = 0.740, p < 0.001).
   Conclusions: RYR-olive extract significantly reduced Lp-PLA(2) in correlation with the marked reduction in plasma OxLDL, which may lead to a reduced risk for cardiovascular disease in patients with MetS.
C1 [Hermans, Nina; Van der Auwera, Anastasia; Breynaert, Annelies; Verlaet, Annelies; De Bruyne, Tess; Pieters, Luc] Univ Antwerp, Nat Prod & Food Res & Anal NatuRA, Dept Pharmaceut Sci, Univ Pl 1, Antwerp, Belgium.
   [Van Gaal, Luc] Antwerp Univ Hosp, Dept Endocrinol Diabetol & Metab, Wilrijkstr 10, B-2650 Edegem, Belgium.
   [Verhoeven, Veronique] Univ Antwerp, Fac Med & Hlth Sci, Acad Ctr Primary & Interdisciplinary Care, Univ Pl 1, Antwerp, Belgium.
C3 University of Antwerp; University of Antwerp; University of Antwerp
RP Hermans, N (corresponding author), Univ Antwerp, Nat Prod & Food Res & Anal NatuRA, Dept Pharmaceut Sci, Univ Pl 1, Antwerp, Belgium.
EM nina.hermans@uantwerpen.be
RI De Bruyne, Tess/O-6505-2018; Hermans, Nina/A-5244-2017; Verhoeven,
   Veronique/B-5915-2017; Pieters, Luc/P-5820-2016
OI De Bruyne, Tess/0000-0001-8597-2084; Hermans, Nina/0000-0003-3946-7313;
   Verlaet, Annelies/0000-0001-8139-0984; breynaert,
   annelies/0000-0003-0831-615X; Verhoeven, Veronique/0000-0002-3708-6501;
   Pieters, Luc/0000-0002-8288-4254
FU Tilman SA [UA/Tilman SA UA C131092]
FX This study was partly funded by a grant from Tilman SA, which produces
   the product under study (commercially available as Cholesfytolplus)
   (clinical study agreement UA/Tilman SA UA C131092). Tilman had no
   methodological or any other input into the design, execution or
   reporting of this study. Tilman had no access to the detailed study
   protocol, the names of study participants or raw study data. Before
   starting the study, it was agreed specifically that the study would be
   published, regardless of the results.
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NR 35
TC 19
Z9 20
U1 3
U2 16
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1745-6215
J9 TRIALS
JI Trials
PD JUL 3
PY 2017
VL 18
AR 302
DI 10.1186/s13063-017-2058-5
PG 8
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA FA0SB
UT WOS:000405144500003
PM 28673363
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Razzaghy-Azar, M
   Nourbakhsh, M
   Pourmoteabed, A
   Nourbakhsh, M
   Ilbeigi, D
   Khosravi, M
AF Razzaghy-Azar, Maryam
   Nourbakhsh, Mitra
   Pourmoteabed, Abdolreza
   Nourbakhsh, Mona
   Ilbeigi, Davod
   Khosravi, Mohsen
TI An Evaluation of Acylated Ghrelin and Obestatin Levels in Childhood
   Obesity and Their Association with Insulin Resistance, Metabolic
   Syndrome, and Oxidative Stress
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Article
DE ghrelin; obestatin; obesity; insulin resistance; metabolic syndrome;
   oxidative stress
ID PLASMA GHRELIN; GROWTH-HORMONE; CIRCULATING LEVELS; ACTIVE GHRELIN;
   FOOD-INTAKE; CHILDREN; SECRETION; PEPTIDE; GLUCOSE; LEPTIN
AB Background: Ghrelin is a 28-amino acid peptide with an orexigenic property, which is predominantly produced by the stomach. Acylated ghrelin is the active form of this hormone. Obestatin is a 23-amino acid peptide which is produced by post-translational modification of a protein precursor that also produces ghrelin. Obestatin has the opposite effect of ghrelin on food intake. The aim of this study was to evaluate acylated ghrelin and obestatin levels and their ratio in obese and normal-weight children and adolescents, and their association with metabolic syndrome (MetS) parameters. Methods: Serum acyl-ghrelin, obestatin, leptin, insulin, fasting plasma glucose (FPG), lipid profile, and malondialdehyde (MDA) were evaluated in 73 children and adolescents (42 obese and 31 control). Insulin resistance was calculated by a homeostasis model assessment of insulin resistance (HOMA-IR). MetS was determined according to IDF criteria. Results: Acyl-ghrelin levels were significantly lower in obese subjects compared to the control group and lower in obese children with MetS compared to obese subjects without MetS. Obestatin was significantly higher in obese subjects compared to that of the control, but it did not differ significantly among those with or without MetS. Acyl-ghrelin to obestatin ratio was significantly lower in obese subjects compared to that in normal subjects. Acyl-ghrelin showed significant negative and obestatin showed significant positive correlations with body mass index (BMI), BMI Z-score, leptin, insulin, and HOMA-IR. Acyl-ghrelin had a significant negative correlation with MDA as an index of oxidative stress. Conclusion: Ghrelin is decreased and obestatin is elevated in obesity. Both of these hormones are associated with insulin resistance, and ghrelin is associated with oxidative stress. The balance between ghrelin and obestatin seems to be disturbed in obesity.
C1 [Razzaghy-Azar, Maryam] Univ Tehran Med Sci, Metab Disorders Res Ctr, Endocrinol & Metab Mol Cellular Sci Inst, Tehran 1411715851, Iran.
   [Razzaghy-Azar, Maryam; Pourmoteabed, Abdolreza; Nourbakhsh, Mona] Iran Univ Med Sci, H Aliasghar Hosp, Tehran 1449614535, Iran.
   [Nourbakhsh, Mitra; Khosravi, Mohsen] Iran Univ Med Sci, Sch Med, Dept Biochem, Tehran 1449614535, Iran.
   [Ilbeigi, Davod] Univ Tehran Med Sci, Sch Med, Dept Biochem, Tehran 1417614418, Iran.
C3 Tehran University of Medical Sciences; Iran University of Medical
   Sciences; Iran University of Medical Sciences; Tehran University of
   Medical Sciences
RP Nourbakhsh, M (corresponding author), Iran Univ Med Sci, Sch Med, Dept Biochem, Tehran 1449614535, Iran.
EM mrazar@tums.ac.ir; Nourbakhsh.m@iums.ac.ir; a_p_808@yahoo.com;
   dr.mnrbh@yahoo.com; ildavod@yahoo.com; dara1khosravi@gmail.com
RI Ilbeigi, Davod/AAC-3493-2020; Nourbakhsh, Mitra/D-5214-2018; nourbakhsh,
   Mona/O-9521-2018; Razzaghy-Azar, Maryam/E-4968-2011
OI khosravi, mohsen/0000-0001-9815-7695
FU Tehran University of Medical Sciences and Health Services
   [91-04-30-20238]
FX This research was supported by Tehran University of Medical Sciences and
   Health Services grant number 91-04-30-20238. The cost of publication was
   not covered by this grant.
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NR 62
TC 29
Z9 30
U1 0
U2 10
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD JUL
PY 2016
VL 5
IS 7
AR 61
DI 10.3390/jcm5070061
PG 10
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA DQ7EJ
UT WOS:000379369400002
PM 27348010
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU de Aguiar, LGK
   Laflor, CM
   Bahia, L
   Villela, NR
   Wiernsperger, N
   Bottino, DA
   Bouskela, E
AF Kraemer de Aguiar, L. G.
   Laflor, C. M.
   Bahia, L.
   Villela, N. R.
   Wiernsperger, N.
   Bottino, D. A.
   Bouskela, E.
TI Metformin improves skin capillary reactivity in normoglycaemic subjects
   with the metabolic syndrome
SO DIABETIC MEDICINE
LA English
DT Article
DE metabolic syndrome; metformin; microvascular disease; oxidative stress
ID LIFE-STYLE INTERVENTION; MICROVASCULAR FUNCTION; INSULIN-RESISTANCE;
   ENDOTHELIAL DYSFUNCTION; CARDIOVASCULAR-DISEASE; OXIDATIVE STRESS;
   OBESITY; RISK; HYPERTENSION; RELEVANCE
AB Aims Insulin resistance and a parental history of diabetes mellitus are independently associated with endothelial dysfunction. Oxidative stress has a pivotal role in the pathophysiology of vascular injury. Metformin, in addition to its glucose-lowering properties, has vasculoprotective effects. We investigated whether metformin has beneficial effects on the nutritive skin capillary circulation and deceases oxidative stress in a group at high risk for Type 2 diabetes mellitus (T2DM) and cardiovascular disease.
   Methods Thirty normoglycaemic subjects with the metabolic syndrome (MS), who had first-degree relatives with T2DM, participated. The mean age was 39.1 +/- 8.4 years and body mass index (BMI) 35.7 +/- 4.8 kg/m(2) (mean +/- SD). Subjects were randomized 1 : 1 to receive placebo (n = 14) or metformin (n = 16; 1700 mg/day) in a double-blind study. At baseline and post treatment, blood and urine samples were collected for biochemical and 8-epi-prostaglandin F-2 alpha (8-epi-PGF(2 alpha)) analysis, respectively. Microcirculation was assessed by nailfold videocapillaroscopy, analysing afferent (AF), efferent (EF) and apical (AP) diameters of capillary loops, functional capillary density (FCD), red blood cell velocity at rest (RBCV), after 1 min arterial occlusion (RBCVmax) and time (TRBCVmax) taken to reach it.
   Results Groups did not differ significantly in anthropometric, clinical, laboratory or microvascular measurements at baseline. In the metformin group, weight, BMI, systolic blood pressure and fasting plasma glucose fell, and lipid profile and microcirculatory parameters FCD, AF, EF, AP, RBCVmax and TRBCVmax improved (all P < 0.01). No relationship between clinico-laboratory parameters and microvascular reactivity was observed, except for changes in total and low-density lipoprotein-cholesterol and RBCVmax. 8-epi-PGF(2 alpha) did not change significantly in either group.
   Conclusions Metformin improved skin capillary reactivity in normoglycaemic MS subjects independently of significant changes in 8-epi-PGF(2 alpha) levels.
C1 Univ Estado Rio de Janeiro, Dept Physiol Sci, Lab Pesquisas Microcirculacao, Rio De Janeiro, Brazil.
C3 Universidade do Estado do Rio de Janeiro
RP de Aguiar, LGK (corresponding author), Rua Candido Mendes 279-303, BR-20241220 Rio De Janeiro, Brazil.
EM gkraemer@ig.com.br
RI Kraemer-Aguiar, Luiz Guilherme/ABG-2833-2022; Bottino,
   Daniel/HGC-9753-2022
OI Kraemer-Aguiar, Luiz Guilherme/0000-0002-3528-5881
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NR 47
TC 27
Z9 33
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0742-3071
EI 1464-5491
J9 DIABETIC MED
JI Diabetic Med.
PD MAR
PY 2007
VL 24
IS 3
BP 272
EP 279
DI 10.1111/j.1464-5491.2007.02082.x
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 136MJ
UT WOS:000244227600008
PM 17263761
DA 2025-06-11
ER

PT J
AU Tang, YL
   Cheng, YL
   Ren, YP
   Yu, XN
   Shentu, XC
AF Tang, Ye-Lei
   Cheng, Ya-Lan
   Ren, Yu-Ping
   Yu, Xiao-Ning
   Shentu, Xing-Chao
TI Metabolic syndrome risk factors and dry eye syndrome: a Meta-analysis
SO INTERNATIONAL JOURNAL OF OPHTHALMOLOGY
LA English
DT Article
DE dry eye syndrome; hypertension; hyperglycemia; obesity; hyperlipidemia;
   Meta-analysis
ID PREVALENCE; DISEASE; POPULATION; DEPRESSION; HEALTH
AB AIM: To explore the relationship between metabolic risk factors and dry eye syndrome (DES).
   METHODS: Retrieved studies on the association of metabolic syndrome risk factors (hypertension, hyperglycemia, obesity, and hyperlipidemia) and DES were collected from PubMed, Web of Science, and the Cochrane Library in December 2015. Odds ratio (OR) with 95% confidence interval (CI) were pooled to evaluate the final relationship. Subgroup analyses were conducted according to diagnostic criteria of DES.
   RESULTS: Nine cross -sectional studies and three case-control studies were included in this Meta-analysis. The pooled results showed that people with hypertension, hyperglycemia, and hyperlipidemia had a higher risk of suffering from DES (P<0.05), especially the typical DES symptoms. On the other hand, obesity did not increase the risk of DES.
   CONCLUSION: The present Meta -analysis suggests that all metabolic risk factors except obesity were risk factors for DES.
C1 [Tang, Ye-Lei] Zhejiang Univ, Sch Med, Affiliated Hosp 2, Dept Neurol, Hangzhou 310000, Zhejiang, Peoples R China.
   [Cheng, Ya-Lan; Ren, Yu-Ping; Yu, Xiao-Ning; Shentu, Xing-Chao] Zhejiang Univ, Sch Med, Affiliated Hosp 2, Eye Ctr, 88 Jiefang Rd, Hangzhou 310000, Zhejiang, Peoples R China.
C3 Zhejiang University; Zhejiang University
RP Shentu, XC (corresponding author), Zhejiang Univ, Sch Med, Affiliated Hosp 2, Eye Ctr, 88 Jiefang Rd, Hangzhou 310000, Zhejiang, Peoples R China.
EM stxc20030304@aliyun.com
FU National Natural Science Foundation of China [81371000]; Foundation from
   Health and Family Planning Commission of Zhejiang Province [WKJ-ZJ-17];
   Zhejiang Key Laboratory Fund of China [2011E10006]
FX Supported by the National Natural Science Foundation of China
   (No.81371000); the Foundation from Health and Family Planning Commission
   of Zhejiang Province (WKJ-ZJ-17); Zhejiang Key Laboratory Fund of China
   (No.2011E10006).
CR Ahn JM, 2014, AM J OPHTHALMOL, V158, P1205, DOI 10.1016/j.ajo.2014.08.021
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NR 27
TC 26
Z9 26
U1 2
U2 16
PU IJO PRESS
PI XI AN
PA NO 269 YOUYI EAST RD, XI AN, 710054, PEOPLES R CHINA
SN 2222-3959
EI 2227-4898
J9 INT J OPHTHALMOL-CHI
JI Int. J. Ophthalmol.
PD JUL 18
PY 2016
VL 9
IS 7
BP 1038
EP 1045
DI 10.18240/ijo.2016.07.17
PG 8
WC Ophthalmology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Ophthalmology
GA DT2XR
UT WOS:000381345600018
PM 27500114
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Ortiz, MS
   Myers, HF
   Schetter, CD
   Rodriguez, CJ
   Seeman, TE
AF Ortiz, Manuel S.
   Myers, Hector F.
   Schetter, Christine Dunkel
   Rodriguez, Carlos J.
   Seeman, Teresa E.
TI Psychosocial Predictors of Metabolic Syndrome among Latino Groups in the
   Multi-Ethnic Study of Atherosclerosis (MESA)
SO PLOS ONE
LA English
DT Article
ID MEXICAN-AMERICAN WOMEN; STRESSFUL LIFE EVENTS; DEPRESSIVE SYMPTOMS;
   CARDIOVASCULAR-DISEASE; PSYCHIATRIC-DISORDERS; SOCIAL SUPPORT;
   RISK-FACTORS; PREVALENCE; HEALTH; ACCULTURATION
AB Objective
   We sought to determine the contribution of psychological variables to risk for metabolic syndrome (MetS) among Latinos enrolled in the Multi-Ethnic Study of Atherosclerosis (MESA), and to investigate whether social support moderates these associations, and whether inflammatory markers mediate the association between psychological variables and MetS.
   Research design and methods
   Cross-sectional analyses at study baseline were conducted with a national Latino cohort (n = 1,388) that included Mexican Americans, Dominican Americans, Puerto Rican Americans and Central/South Americans. Hierarchical logistic regression analyses were conducted to test the effects of psychosocial variables (chronic stress, depressive symptoms, and social support) on MetS. In addition, separate subgroup-specific models, controlling for nationality, age, gender, socioeconomic position, language spoken at home, exercise, smoking and drinking status, and testing for the effects of chronic stress, depressive symptoms and inflammation (IL-6, CRP, fibrinogen) in predicting risk for MetS were conducted.
   Results
   In the overall sample, high chronic stress independently predicted risk for MetS, however this association was found to be significant only in Mexican Americans and Puerto Rican Americans. Social support did not moderate the associations between chronic stress and MetS for any group. Chronic stress was not associated with inflammatory markers in either the overall sample or in each group.
   Conclusions
   Our results suggest a differential contribution of chronic stress to the prevalence of MetS by national groups.
C1 [Ortiz, Manuel S.] Univ La Frontera, Dept Psychol, Temuco, Chile.
   [Myers, Hector F.] Vanderbilt Univ, Ctr Med Hlth & Soc & Psychol, Nashville, TN 37235 USA.
   [Schetter, Christine Dunkel] Univ Calif Los Angeles, Dept Psychol, Los Angeles, CA 90024 USA.
   [Rodriguez, Carlos J.] Wake Forest Univ, Bowman Gray Sch Med, Dept Med, Div Publ Hlth Sci, Winston Salem, NC 27103 USA.
   [Seeman, Teresa E.] Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90095 USA.
C3 Universidad de La Frontera; Vanderbilt University; University of
   California System; University of California Los Angeles; Wake Forest
   University; Wake Forest Baptist Medical Center; University of California
   System; University of California Los Angeles; University of California
   Los Angeles Medical Center; David Geffen School of Medicine at UCLA
RP Ortiz, MS (corresponding author), Univ La Frontera, Dept Psychol, Temuco, Chile.
EM manuel.ortiz@ufrontera.cl
RI Ortiz, Manuel/G-1044-2019
OI Ortiz, Manuel/0000-0002-7749-0699
FU National Heart, Lung, and Blood Institute [N01 HC95159, N01 HC-95160,
   N1HC95161, UL1-RR-024156, N01 HC-95162, UL1-RR-025005, N01 HC-95163, N01
   HC-95164, N01 HC95165, N01HC95166]; NCRR [UL1-RR-024156, UL1-RR-025005]
FX This research was supported by contracts N01 HC95159; N01 HC-95160;
   N1HC95161; UL1-RR- 024156; N01 HC-95162; UL1-RR-025005; N01 HC-95163;
   N01 HC-95164; N01 HC95165; N01HC95166 from the National Heart, Lung, and
   Blood Institute and by grants UL1-RR-024156 and UL1-RR-025005 from NCRR.
   The authors thank the other investigators, the staff, and the
   participants of the MESA study for their valuable contributions. A full
   list of participating MESA investigators and institutions can be found
   at http://www.mesa-nhlbi.org. The funders had no role in study design,
   data collection and analysis, decision to publish, or preparation of the
   manuscript.
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NR 44
TC 18
Z9 23
U1 0
U2 2
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD APR 23
PY 2015
VL 10
IS 4
AR e0124517
DI 10.1371/journal.pone.0124517
PG 12
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Science & Technology - Other Topics
GA CG5KZ
UT WOS:000353332000072
PM 25906072
OA gold, Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Zelber-Sagi, S
   Ben-Assuli, O
   Rabinowich, L
   Goldstein, A
   Magid, A
   Shalev, V
   Shibolet, O
   Chodick, G
AF Zelber-Sagi, Shira
   Ben-Assuli, Ofir
   Rabinowich, Liane
   Goldstein, Alex
   Magid, Avi
   Shalev, Varda
   Shibolet, Oren
   Chodick, Gabriel
TI The association between the serum levels of uric acid and alanine
   aminotransferase in a population-based cohort
SO LIVER INTERNATIONAL
LA English
DT Article
DE metabolic syndrome; nonalcoholic fatty liver disease; real-world data;
   uric acid
ID NONALCOHOLIC FATTY LIVER; ALL-CAUSE MORTALITY; METABOLIC SYNDROME;
   INSULIN-RESISTANCE; HEPATIC STEATOSIS; NATIONAL-HEALTH; UNITED-STATES;
   CARDIOVASCULAR RISK; OXIDATIVE STRESS; PRIMARY-CARE
AB Background & AimsElevated serum uric acid levels reflect and also cause both oxidative stress and insulin resistance and are frequently observed in patients with the metabolic syndrome. A strong association exists between the metabolic syndrome and non-alcoholic fatty liver disease (NAFLD). Therefore, we aimed to test the association between uric acid and elevated alanine aminotransferase (ALT), as a surrogate for NAFLD, using real-world data.
   MethodsData used for the cross-sectional study were obtained from Maccabi Healthcare System, a 2-million member health maintenance organization in Israel. The population consisted of individuals aged 20-60years who underwent blood tests for ALT and uric acid between 1997 and 2012. Individuals with secondary liver disease, celiac, and inflammatory bowel-disease were excluded. Subgroup analysis was performed in subjects who were given the diagnosis of fatty liver in their medical records (n=2628).
   ResultsThe study population included 82608 people (32.5% men, mean age 43.9110.15years). There was a significant positive dose-response association between serum uric acid levels and the rate of elevated serum ALT (P for trend <0.001). In multivariable model, controlling for potential confounders, the association between uric acid and elevated ALT persisted (OR=2.10, 95% CI 1.93-2.29, for the fourth quartile vs. the first). This association was maintained in all categories of gender and BMI. Similar results were observed among patients diagnosed with fatty liver (OR=1.77, 1.22-2.57).
   ConclusionsSerum uric acid is independently associated with elevated ALT, as a surrogate for NAFLD, and thus may serve as a serum marker for liver damage and should be further investigated as a risk factor for NAFLD.
C1 [Zelber-Sagi, Shira; Magid, Avi] Univ Haifa, Sch Publ Hlth, IL-31999 Haifa, Israel.
   [Zelber-Sagi, Shira; Rabinowich, Liane; Shibolet, Oren] Tel Aviv Med Ctr & Sch Med, Dept Gastroenterol, Liver Unit, IL-64239 Tel Aviv, Israel.
   [Ben-Assuli, Ofir] Fac Business Adm, Ono Acad Coll, Kiryat Ono, Israel.
   [Goldstein, Alex; Shalev, Varda; Chodick, Gabriel] Maccabi Healthcare Serv, Div Med, Tel Aviv, Israel.
   [Shibolet, Oren; Chodick, Gabriel] Tel Aviv Univ, Sackler Fac Med, IL-69978 Tel Aviv, Israel.
C3 University of Haifa; Tel Aviv University; Sackler Faculty of Medicine;
   Tel Aviv University; Sackler Faculty of Medicine
RP Zelber-Sagi, S (corresponding author), Tel Aviv Med Ctr & Sch Med, Dept Gastroenterol, Liver Unit, IL-64239 Tel Aviv, Israel.
EM zelbersagi@bezeqint.net
RI Ben-Assuli, Ofir/AFI-2709-2022; chodick, gabby/AFP-0827-2022
OI Goldstein, Alex/0000-0002-5672-9314; Ben-Assuli,
   Ofir/0000-0002-1975-6647; /0000-0002-5189-8995
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NR 70
TC 23
Z9 29
U1 0
U2 11
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1478-3223
EI 1478-3231
J9 LIVER INT
JI Liver Int.
PD NOV
PY 2015
VL 35
IS 11
BP 2408
EP 2415
DI 10.1111/liv.12842
PG 8
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA CU3GI
UT WOS:000363411900009
PM 25845417
DA 2025-06-11
ER

PT J
AU Vítek, L
AF Vitek, Libor
TI The role of bilubinin diabetes, metabolic syndrome, and cardiovascular
   diseases
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Review
DE bilirubin; biliverdin; biliverdin reductase; cardiovascular diseases;
   diabetes; heme oxygenase; metabolic syndrome; UGT1A1
ID IMPROVES INSULIN SENSITIVITY; HUMAN BILIVERDIN REDUCTASE; HEME OXYGENASE
   SYSTEM; SERUM BILIRUBIN CONCENTRATION; GLYCATION END-PRODUCTS;
   GLUCOSE-METABOLISM; OXIDATIVE STRESS; GILBERT-SYNDROME; INVERSE
   ASSOCIATION; CARBON-MONOXIDE
AB Bilirubin belongs to a phylogenetically old superfamily of tetrapyrrolic compounds, which have multiple biological functions. Although for decades bilirubin was believed to be only a waste product of the heme catabolic pathway at best, and a potentially toxic compound at worst; recent data has convincingly demonstrated that mildly elevated serum bilirubin levels are strongly associated with a lower prevalence of oxidative stress-mediated diseases. Indeed, serum bilirubin has been consistently shown to be negatively correlated to cardiovascular diseases (CVD), as well as to CVD-related diseases and risk factors such as arterial hypertension, diabetes mellitus, metabolic syndrome, and obesity. In addition, the clinical data are strongly supported by evidence arising from both in vitro and in vivo experimental studies. This data not only shows the protective effects of bilirubin per se; but additionally, of other products of the heme catabolic pathway such as biliverdin and carbon monoxide, as well as its key enzymes (heme oxygenase and biliverdin reductase); thus, further underlining the biological impacts of this pathway. In this review, detailed information on the experimental and clinical evidence between the heme catabolic pathway and CVD, and those related diseases such as diabetes, metabolic syndrome, and obesity is provided. All of these pathological conditions represent an important threat to human civilization, being the major killers in developed countries, with a steadily increasing prevalence. Thus, it is extremely important to search for novel markers of these diseases, as well as for novel therapeutic modalities to reverse this unfavorable situation. The heme catabolic pathway seems to fulfill the criteria for both diagnostic purposes as well as for potential therapeutical interventions.
C1 [Vitek, Libor] Charles Univ Prague, Fac Med 1, Dept Internal Med 4, Prague 12808 2, Czech Republic.
   [Vitek, Libor] Charles Univ Prague, Fac Med 1, Inst Med Biochem & Lab Diagnost, Prague 12808 2, Czech Republic.
C3 Charles University Prague; Charles University Prague
RP Vítek, L (corresponding author), Charles Univ Prague, Fac Med 1, Inst Med Biochem & Lab Diagnost, Cent Res Labs, Na Bojisti 3, Prague 12808 2, Czech Republic.
EM vitek@cesnet.cz
RI Vitek, Libor/A-2645-2008
OI Vitek, Libor/0000-0002-5318-0151
FU Czech Ministry of Education [SVV-2011-262513, LH11030]; Czech Ministry
   of Health [NS 9770-4-28]; Charles University in Prague [Prvouk
   P25/LF1/2]; Research Granting Agency of the Czech Republic [CZ:GA
   CR:P206/11/0836]
FX This work was partly supported by grants SVV-2011-262513 and LH11030,
   from the Czech Ministry of Education; grant NS 9770-4-28 from the Czech
   Ministry of Health, grant Prvouk P25/LF1/2 from the Charles University
   in Prague and grant CZ:GA CR:P206/11/0836 from the Research Granting
   Agency of the Czech Republic
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NR 92
TC 245
Z9 261
U1 4
U2 25
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PY 2012
VL 3
AR 55
DI 10.3389/fphar.2012.00055
PG 7
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA V35XE
UT WOS:000209177700054
PM 22493581
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Virzi, NE
   Krantz, DS
   Bittner, VA
   Merz, CNB
   Reis, SE
   Handberg, EM
   Pepine, CJ
   Vaccarino, V
   Rutledge, T
AF Virzi, Nicole E.
   Krantz, David S.
   Bittner, Vera A.
   Merz, C. Noel Bairey
   Reis, Steven E.
   Handberg, Eileen M.
   Pepine, Carl J.
   Vaccarino, Viola
   Rutledge, Thomas
TI Depression symptom patterns as predictors of metabolic syndrome and
   cardiac events in symptomatic women with suspected myocardial ischemia:
   The women's ischemia syndrome evaluation (WISE and WISE-CVD) projects
SO HEART AND MIND
LA English
DT Article
DE Cardiovascular disease; cognitive and somatic symptoms; depression;
   ischemia; women
AB Background: Ischemic heart disease (IHD) risk in women includes biomedical, behavioral, and psychosocial contributors. The purpose of this study was to build upon previous research suggesting that in women, somatic symptoms (SS) of depression may be important to the development of IHD risk factors and major adverse cardiovascular events (MACE). Based on previous findings, we hypothesized that: (1) SS would be associated with robust biomedical predictors of heart disease and functional capacity, while cognitive symptoms (CS) of depression would not, and (2) SS would independently predict adverse health outcomes while CS would not. Methods: We examined the relationships between symptoms of depression (SS/CS), metabolic syndrome (MetS), inflammatory markers (IM), coronary artery disease (CAD) severity, and functional capacity in two independent cohorts of women with suspected IHD. In the Women's Ischemia Syndrome Evaluation (WISE), we also examined these variables as predictors of all-cause mortality (ACM) + MACE over a median 9.3-year follow-up. The WISE sample included 641 women with suspected ischemia with or without obstructive CAD. The WISE-Coronary Vascular Dysfunction (WISE-CVD) sample consisted of 359 women with suspected ischemia and no obstructive CAD. All study measures were collected uniformly at baseline. Depressive symptoms were measured via the Beck Depression Inventory. MetS was assessed according to Adult Treatment Panel III (ATP-III) criteria. Results: In both studies, SS was associated with MetS (Cohen's d = 0.18, 0.26, P < 0.05, respectively), while CS was not. Within WISE, using Cox Proportional Hazard Regression, SS (Hazard ratio [HR] = 1.08, 95% confidence interval [CI] = 1.01-1.15; HR = 1.07, 95% CI = 1.00-1.13) and MetS (HR = 1.89, 95% CI = 1.16-3.08; HR = 1.74, 95% CI=1.07-2.84) were independent predictors of ACM + MACE after controlling for demographics, IM, and CAD severity, while CS was not. Conclusions: In two independent samples of women undergoing coronary angiography due to suspected ischemia, SS but not CS of depression were associated with MetS, and both SS and MetS independently predicted ACM and MACE. These results add to previous studies suggesting that SS of depression may warrant specific attention in women with elevated cardiovascular disease (CVD) risk. Future research evaluating the biobehavioral basis of the relationship between depression, MetS, and CVD is needed.
C1 [Virzi, Nicole E.] San Diego State Univ Univ Calif San Diego Joint D, Dept Clin Psychol, San Diego, CA USA.
   [Krantz, David S.] Uniformed Serv Univ Hlth Sci, Dept Med & Clin Psychol, Bethesda, MD 20814 USA.
   [Bittner, Vera A.] Univ Alabama Birmingham, Dept Med, Div Cardiovasc Dis, Birmingham, AL 35294 USA.
   [Merz, C. Noel Bairey] Cedars Sinai Smidt Heart Inst, Barbra Streis & Womens Heart Ctr, Los Angeles, CA USA.
   [Reis, Steven E.] Univ Pittsburgh, Dept Med, Pittsburgh, PA USA.
   [Handberg, Eileen M.; Pepine, Carl J.] Univ Florida, Dept Med, Div Cardiovasc Med, Gainesville, FL USA.
   [Vaccarino, Viola] Emory Univ, Dept Med, Div Cardiol, Atlanta, GA 30322 USA.
   [Rutledge, Thomas] VA San Diego Healthcare Syst, Psychol Serv, San Diego, CA USA.
   [Rutledge, Thomas] Univ Calif San Diego, Dept Psychiat, San Diego, CA 92103 USA.
C3 California State University System; San Diego State University;
   Uniformed Services University of the Health Sciences - USA; University
   of Alabama System; University of Alabama Birmingham; Cedars Sinai
   Medical Center; Pennsylvania Commonwealth System of Higher Education
   (PCSHE); University of Pittsburgh; State University System of Florida;
   University of Florida; Emory University; US Department of Veterans
   Affairs; Veterans Health Administration (VHA); VA San Diego Healthcare
   System; University of California System; University of California San
   Diego
RP Rutledge, T (corresponding author), VA San Diego Healthcare Syst, Psychol Serv 116B, 3350 La Jolla Village Dr, San Diego, CA 92161 USA.
EM thomas.rutledge@va.gov
RI Reis, Steven/J-3957-2014; Vaccarino, Viola/AAW-5600-2020; Krantz,
   David/L-5364-2015
OI Krantz, David/0000-0002-1671-1355
FU National Heart, Lung and Blood Institutes [N01-HV-68161, N01-HV-68162,
   N01-HV-68163, N01-HV-68164, U01 64829, U01 HL649141, U01 HL649241,
   K23HL105787, K23HL127262, K23HL125941, R01 HL090957, R01HL124649, U54
   AG065141, 1R03 AG032631]; National Institute on Aging, GCRC grant
   [MO1-RR00425]; National Center for Research Resources; National Center
   for Advancing Translational Sciences [UL1TR000124, UL1TR000064]; Edythe
   L. Broad Women's Heart Research Fellowship - Cedars-Sinai Medical
   Center, Los Angeles, California; Constance Austin Women's Heart Health
   Fellowship- Cedars-Sinai Medical Center, Los Angeles, California; Barbra
   Streisand Women's Cardiovascular Research and Education Program,
   Cedars-Sinai Medical Center, Los Angeles; Linda Joy Pollin Women's Heart
   Health Program; Erika Glazer Women's Heart Health Project; National
   Institute of Health [HL33610, HL56921, UM1 HL087366]; Gatorade Trust and
   the McJunkin Family Foundation; University of Florida; Department of
   National Institute on Aging, GCRC; NIH NCATS-University of Florida
   Clinical and Translational Science [UL1TR001427]; PCORnet-OneFlorida
   Clinical Research Consortium [CDRN-1501-26692]
FX This work was supported by contracts from the National Heart, Lung and
   Blood Institutes, nos. N01-HV-68161, N01-HV-68162, N01-HV-68163,
   N01-HV-68164, grants U01 64829, U01 HL649141, U01 HL649241, K23HL105787,
   K23HL127262, K23HL125941, R01 HL090957, R01HL124649, U54 AG065141, 1R03
   AG032631 from the National Institute on Aging, GCRC grant MO1-RR00425
   from the National Center for Research Resources, the National Center for
   Advancing Translational Sciences Grant UL1TR000124 and UL1TR000064, and
   the Edythe L. Broad Women's Heart Research Fellowship, the Constance
   Austin Women's Heart Health Fellowship, both at Cedars-Sinai Medical
   Center, Los Angeles, California, the Barbra Streisand Women's
   Cardiovascular Research and Education Program, Cedars-Sinai Medical
   Center, Los Angeles, the Linda Joy Pollin Women's Heart Health Program,
   and the Erika Glazer Women's Heart Health Project. Dr. Pepine was also
   supported by National Institute of Health grants HL33610, HL56921; UM1
   HL087366; the Gatorade Trust and the McJunkin Family Foundation through
   funds distributed by the University of Florida, Department of National
   Institute on Aging, GCRC grantMedicine; NIH NCATS-University of Florida
   Clinical and Translational Science UL1TR001427; and PCORnet-OneFlorida
   Clinical Research Consortium CDRN-1501-26692.
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NR 41
TC 8
Z9 8
U1 2
U2 2
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, Maharashtra, INDIA
SN 2468-6476
EI 2468-6484
J9 HEART MIND
JI Heart Mind
PD OCT-DEC
PY 2022
VL 6
IS 4
BP 254
EP 261
DI 10.4103/hm.hm_35_22
PG 8
WC Cardiac & Cardiovascular Systems; Psychiatry
WE Emerging Sources Citation Index (ESCI)
SC Cardiovascular System & Cardiology; Psychiatry
GA CF3N3
UT WOS:001123797800011
PM 36994354
OA gold
DA 2025-06-11
ER

PT J
AU Zák, A
   Jáchymová, M
   Tvrzická, E
   Vecka, M
   Duffková, L
   Zeman, M
   Slaby, A
   Stanková, B
AF Zak, Ales
   Jachymova, Marie
   Tvrzicka, Eva
   Vecka, Marek
   Duffkova, Ladislava
   Zeman, Mlroslav
   Slaby, Adolf
   Stankova, Barbora
TI The influence of polymorphism of -493G/T MTP gene promoter and
   metabolic syndrome on lipids, fatty acids and oxidative stress
SO JOURNAL OF NUTRITIONAL BIOCHEMISTRY
LA English
DT Article
DE microsomal triglyceride transfer protein; metabolic syndrome;
   atherogenic dyslipidemia; fatty acid profile; oxidative stress
ID TRIGLYCERIDE TRANSFER PROTEIN; MIDDLE-AGED MEN; BETA-CELL FUNCTION;
   INSULIN-RESISTANCE; FUNCTIONAL POLYMORPHISM; PLASMA-LIPOPROTEINS;
   SERUM-LIPIDS; DIETARY-FAT; APO-B; ASSOCIATION
AB The aim of this study was to investigate the effect of the microsomal triglyceride transfer protein (MTP) -493G/T polymorphism on clinical and biochemical parameters in relation to the presence of metabolic syndrome (MS). A group of 270 participants, 143 men and 127 women [50 men/36 women fulfilled the International Diabetes Federation (IDF) criteria of MS], was categorized on the basis of the MTP -493G/T polymorphism: GG homozygotes (Group GG) and carriers of the T allele (Group TT+TG). In men with MS, the presence of the T allele was associated with elevated concentrations of plasma insulin (by 48%, P <.01) and nonesterified fatty acids (by 49%, P <.05); homcostasis model assessment for insulin resistance index was higher by 64% (P <.05). Carriers of the T allele were further characterized by elevated plasma concentrations of total cholesterol (by 14%, P <.05) and by increased triglycerides in plasma (by 95%, P <.01) and in very low-density lipoprotein (by 106%, P <.01). They also had lower concentrations of n-6 polyunsaturated fatty acids in plasma phospholipids (by 3.5%, P <.05), lower Delta 5-desaturase activities (by 18%, P <.05) and elevated concentrations of conjugated dienes in low-density lipoprotein (by 29%, P <.01). No significant differences between Groups GG and TT+TG were found in men without MS and in women with and without MS. Our results imply evidence for interactive effects of genetic, metabolic and gender-specific factors on several components of metabolic syndrome, which can increase the risk for cardiovascular disease. (c) 2008 Elsevier Inc. All rights reserved.
C1 [Zak, Ales; Jachymova, Marie; Tvrzicka, Eva; Vecka, Marek; Duffkova, Ladislava; Zeman, Mlroslav; Slaby, Adolf; Stankova, Barbora] Charles Univ Prague, Fac Med 1, Dept Internal Med 4, Gen Teaching Hosp, Prague, Czech Republic.
C3 General University Hospital Prague; Charles University Prague
RP Zák, A (corresponding author), Charles Univ Prague, Fac Med 1, Dept Internal Med 4, Gen Teaching Hosp, Prague, Czech Republic.
EM azak@vfn.cz
RI Slaby, Adolf/P-5060-2016; Stankova, Barbora/L-7933-2016; Zeman,
   Miroslav/J-5281-2016; Tvrzicka, Eva/Q-6300-2016; Vecka,
   Marek/A-3560-2008; Zak, Ales/G-8318-2016
OI Stankova, Barbora/0000-0002-6184-4878; Zeman,
   Miroslav/0000-0001-5338-603X; Tvrzicka, Eva/0000-0003-0794-8454; Vecka,
   Marek/0000-0002-3269-1817; Slaby, Adolf/0000-0003-3036-1221; Zak,
   Ales/0000-0002-1698-6068
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NR 56
TC 18
Z9 18
U1 0
U2 8
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0955-2863
EI 1873-4847
J9 J NUTR BIOCHEM
JI J. Nutr. Biochem.
PD SEP
PY 2008
VL 19
IS 9
BP 634
EP 641
DI 10.1016/j.jnutbio.2007.09.001
PG 8
WC Biochemistry & Molecular Biology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Nutrition & Dietetics
GA 342ME
UT WOS:000258787400009
PM 18280132
DA 2025-06-11
ER

PT J
AU Wei, X
   Li, SQ
   Yue, WW
   Zhang, ZP
   Wei, J
   Wang, LQ
   Hu, B
   Long, N
   Li, C
   Hou, BM
   Feng, J
   Luo, CM
AF Wei, Xing
   Li, Siqi
   Yue, Wenwen
   Zhang, Zhipeng
   Wei, Jing
   Wang, Liqi
   Hu, Ben
   Long, Nv
   Li, Chao
   Hou, Bingmei
   Feng, Jun
   Luo, Chunmiao
TI The mediating effects of depression in sedentary behavior and the
   metabolic syndrome with its components
SO BMC PUBLIC HEALTH
LA English
DT Article
DE Metabolic syndrome; Sedentary behavior; Depressive symptoms; Mediation
   effect; NHANES
ID PHYSICAL-ACTIVITY; ASSOCIATION; HEALTH; INFLAMMATION; MORTALITY;
   SYMPTOMS; OBESITY; DISEASE
AB BackgroundPrevious studies have shown a positive association between sedentary behavior (SB) and metabolic syndrome (MetS), but no studies have assessed the mediating effect of depressive symptoms in this process.MethodsParticipants from the 2007-2018 National Health and Nutrition Examination Survey (NHANES) were included. Multiple logistic regression analyses and restricted cubic splines (RCSs) were adopted to assess the correlations among SB duration, depressed mood and MetS. A mediation effect model was constructed to analyze whether there was a mediating effect of depressed mood on the relationship between SB duration and MetS.ResultsThis study included 15,944 adults (7,268 patients with MetS in total). We identified high SB duration as an independent risk factor for MetS in a regression model adjusted for relevant confounders (odds ratio (OR) = 1.29, 95% CI [1.08, 1.53]). RCS analysis revealed a nonlinear relationship between SB duration and MetS. The mediation effect analysis revealed that depressive symptoms accounted for 6.70% of the mediation effect between SB duration and MetS. Depressive symptoms were also partially mediated in the analyses with MetS subcomponents.ConclusionSB is closely associated with MetS, and this association is not only caused by SB itself but also partially mediated by depressive symptoms.
C1 [Wei, Xing; Yue, Wenwen; Zhang, Zhipeng; Wei, Jing; Hu, Ben; Long, Nv; Li, Chao; Feng, Jun; Luo, Chunmiao] Anhui Med Univ, Peoples Hosp Hefei 2, Dept Cardiol, Hefei Hosp, Hefei 230011, Anhui, Peoples R China.
   [Wei, Xing; Li, Siqi; Yue, Wenwen; Zhang, Zhipeng; Wei, Jing; Hu, Ben; Long, Nv; Hou, Bingmei] Anhui Med Univ, Clin Sch Med 5, Hefei 230032, Anhui, Peoples R China.
   [Wang, Liqi] Anhui Med Univ, Peoples Hosp Hefei 2, Hefei Hosp, Hefei 230011, Anhui, Peoples R China.
   [Li, Siqi; Hou, Bingmei] Second Peoples Hosp Hefei, Dept Endocrinol, Hefei 230011, Peoples R China.
C3 Anhui Medical University; Anhui Medical University; Anhui Medical
   University
RP Luo, CM (corresponding author), Anhui Med Univ, Peoples Hosp Hefei 2, Dept Cardiol, Hefei Hosp, Hefei 230011, Anhui, Peoples R China.
EM 18714812264@163.com
RI Hu, Ben/NGR-8529-2025; Wang, Liqi/NFT-8277-2025
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NR 44
TC 0
Z9 0
U1 4
U2 4
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2458
J9 BMC PUBLIC HEALTH
JI BMC Public Health
PD MAR 3
PY 2025
VL 25
IS 1
AR 851
DI 10.1186/s12889-025-22030-w
PG 11
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA Z2L5G
UT WOS:001437287100012
PM 40033385
OA gold
DA 2025-06-11
ER

PT J
AU West, IC
AF West, IC
TI Radicals and oxidative stress in diabetes
SO DIABETIC MEDICINE
LA English
DT Review
DE ascorbic acid; diabetes mellitus; glutathione; lipoate; oxidative;
   stress; reactive oxygen species; vitamin E
ID ALDOSE REDUCTASE GENE; ALPHA-LIPOIC ACID; PANCREATIC BETA-CELLS;
   SUPEROXIDE-DISMUTASE; ADVANCED GLYCATION; ANTIOXIDANT ENZYMES;
   LIPID-PEROXIDATION; OXIDANT STRESS; HEART-MITOCHONDRIA;
   HYDROGEN-PEROXIDE
AB Recent evidence is reviewed indicating increased oxidative damage in Type 1 and Type 2 diabetes mellitus as well as deficits in antioxidant defence enzymes and vitamins. Mechanisms are considered whereby hyperglycaemia can increase oxidative stress, and change the redox potential of glutathione and whereby reactive oxygen species can cause hyperglycaemia. It is argued that oxygen, antioxidant defences, and cellular redox status should now be regarded as central players in diabetes and the metabolic syndrome.
C1 Newcastle Univ, Sch Med, Dept Biochem & Genet, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England.
C3 Newcastle University - UK
RP Newcastle Univ, Sch Med, Dept Biochem & Genet, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England.
EM i.c.west@ncl.ac.uk
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NR 103
TC 629
Z9 687
U1 0
U2 63
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0742-3071
EI 1464-5491
J9 DIABETIC MED
JI Diabetic Med.
PD MAR
PY 2000
VL 17
IS 3
BP 171
EP 180
DI 10.1046/j.1464-5491.2000.00259.x
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 308NK
UT WOS:000086719300001
PM 10784220
DA 2025-06-11
ER

PT J
AU Oliva-Olivera, W
   Lhamyani, S
   Coín-Aragüez, L
   Alcaide-Torres, J
   Cardona, F
   El Bekay, R
   Tinahones, FJ
AF Oliva-Olivera, Wilfredo
   Lhamyani, Said
   Coin-Araguez, Leticia
   Alcaide-Torres, Juan
   Cardona, Fernando
   El Bekay, Rajaa
   Tinahones, Francisco J.
TI Involvement of acetyl-CoA-producing enzymes in the deterioration of the
   functional potential of adipose-derived multipotent cells from subjects
   with metabolic syndrome
SO METABOLISM-CLINICAL AND EXPERIMENTAL
LA English
DT Article
DE Metabolic syndrome; Adipose tissue; Adipose tissue-derived mesenchymal
   stem cells; Acetyl-CoA-producing enzymes; Lipogenesis
ID DE-NOVO LIPOGENESIS; INCREASED OXIDATIVE STRESS; FATTY-ACID SYNTHASE;
   INSULIN-RESISTANCE; STEM-CELLS; OSTEOGENIC DIFFERENTIATION;
   GENE-EXPRESSION; DOWN-REGULATION; ACYL-COA; TISSUE
AB Objective: The expansion capacity of white adipose tissue influences the distribution of fat depots in the body, the visceral accumulation of which is linked to metabolic syndrome, regardless of the degree of obesity of the subjects. Alterations in the adipose tissue-derived mesenchymal stem cells (ASCs) may contribute to the adipose tissue remodeling associated with metabolic syndrome and impact the regional distribution of adipose tissue by generating inherently dysfunctional adipocytes. Here we examine the expression levels of acetyl-CoA-producing enzymes and their relationship with the lipogenic, antioxidant and oxidative potential of adipocytes generated from visceral ASCs (adipo-visASCs) and subcutaneous ASCs (adipo-subASCs) from subjects with different metabolic profiles.
   Materials/Methods: Paired samples of visceral and subcutaneous adipose tissue were processed to isolate the respective ASCs from normal-weight (Nw) subjects and obese patients with metabolic syndrome (METS) and without METS (NonMETS). qPCR was used to quantify the expression levels of the genes studied in both adipo-ASCs from the patient groups and those generated after silencing by small interfering RNA of acetylCoA-producing enzymes. The accumulation of lipids was quantified by absorbance.
   Results: No significant differences in cell yield or CD34(+)CD31(-)CD45(-) ASC percentage were observed between the different patient groups. Unlike adipo-visASCs, adipo-subASCs from METS patients showed a decrease in expression levels of acetyl-CoA-producing enzymes as well as proteins linked to lipogenesis, antioxidant defense and fatty acid oxidation. Transcriptional silencing of acetyl-CoA-producing enzymes in adipo-subASCs reduced lipid accumulation and affected transcription levels of lipogenic and antioxidant defense proteins.
   Conclusions: Adipo-subASCs may be more susceptible than adipo-visASCs to deterioration of the lipogenic, oxidative and antioxidant potential associated with metabolic syndrome. Intrinsic alterations in transcription levels of acetyl-CoA-producing enzymes may contribute to the metabolic reprogramming of adipo-subASCs from METS patients. (C) 2018 Elsevier Inc. All rights reserved.
C1 Univ Malaga UMA, Hosp Malaga Virgen de la Victoria, Inst Biomed Res Malaga IBIMA, Dept Clin Endocrinol & Nutr, Malaga, Spain.
   ISCIII, Inst Hlth Carlos III, CIBEROBN, Pathophysiol Obes & Nutr, Madrid, Spain.
C3 Universidad de Malaga; Instituto de Investigacion Biomedica de Malaga y
   Plataforma en Nanomedicina (IBIMA); Instituto de Salud Carlos III; CIBER
   - Centro de Investigacion Biomedica en Red; CIBEROBN
RP Oliva-Olivera, W; El Bekay, R; Tinahones, FJ (corresponding author), Hosp Malaga Virgen de la Victoria, Res Lab, Campus Teatinos S-N,First Floor, Malaga 29010, Spain.
EM oliva_olivera@hotmail.com; elbekay@gmail.com; ftinahones@hotmail.com
RI Tinahones, Francisco/AAB-2882-2020; Cardona, Fernando/AAG-7835-2019;
   Oliva-Olivera, Wilfredo/GSN-7320-2022; LHAMYANI, said/AAQ-1973-2020;
   Bekay, Rajaa/AAZ-3959-2020; Cardona, Fernando/H-6022-2015
OI Oliva Olivera, Wilfredo/0000-0003-3473-7898; El Bekay Rizky,
   RAJAA/0000-0003-3332-3431; Tinahones, Francisco J/0000-0001-6871-4403;
   Cardona, Fernando/0000-0003-4460-6824; LHAMYANI,
   said/0000-0002-9830-9772
FU European Union through the European Regional Development Fund (FEDER);
   Ministry of Economy and Competitiveness, Institute of Health Carlos III
   [PI15/01114, PI13/02628, P112/02355, P114/00082, P111/02518]; Ministry
   of Economy and Knowledge [PI-CTS-08181/2011, CTS-7895/2011]; Nicolas
   Monardes Program from the Andalusian Health Service [C-0032-2016]
FX This work was co-funded by the European Union through the European
   Regional Development Fund (FEDER) and supported by grants from the
   Ministry of Economy and Competitiveness, Institute of Health Carlos III
   (PI15/01114, PI13/02628; P112/02355: P114/00082; P111/02518) and the
   Ministry of Economy and Knowledge (PI-CTS-08181/2011; CTS-7895/2011).
   F.C and R.E.B are under a contract from the Nicolas Monardes Program
   (C-0032-2016) from the Andalusian Health Service.
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NR 56
TC 3
Z9 3
U1 0
U2 7
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0026-0495
EI 1532-8600
J9 METABOLISM
JI Metab.-Clin. Exp.
PD NOV
PY 2018
VL 88
BP 12
EP 21
DI 10.1016/j.metabol.2018.08.004
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA HJ1FS
UT WOS:000456907900002
PM 30172756
DA 2025-06-11
ER

PT J
AU Xia, LP
   Shen, L
   Kou, H
   Zhang, BJ
   Zhang, L
   Wu, Y
   Li, XJ
   Xiong, J
   Yu, Y
   Wang, H
AF Xia, L. P.
   Shen, L.
   Kou, H.
   Zhang, B. J.
   Zhang, L.
   Wu, Y.
   Li, X. J.
   Xiong, J.
   Yu, Y.
   Wang, H.
TI Prenatal ethanol exposure enhances the susceptibility to metabolic
   syndrome in offspring rats by HPA axis-associated neuroendocrine
   metabolic programming
SO TOXICOLOGY LETTERS
LA English
DT Article
DE Prenatal ethanol exposure; Intrauterine growth retardation;
   Hypothalamic-pituitary-adrenal axis; High-fat diet; Metabolic syndrome
ID INTRAUTERINE GROWTH-RETARDATION; PITUITARY-ADRENAL AXIS; HIGH-FAT DIET;
   CORONARY-ARTERY-DISEASE; FOR-GESTATIONAL-AGE; INSULIN-RESISTANCE;
   ALCOHOL EXPOSURE; PERINATAL OUTCOMES; EARLY-PREGNANCY; FETAL ORIGINS
AB Objective: The present study was designed to demonstrate that prenatal ethanol exposure (PEE) could enhance the susceptibility of high-fat diet-induced metabolic syndrome (MS) in adult male offspring via a hypothalamic-pituitary-adrenal (HPA) axis-associated neuroendocrine metabolic programmed mechanism.
   Methods: Pregnant Wistar rats were intragastricly administrated ethanol 4 g/kg d from gestational day 11 until term delivery. All male offspring were fed with high-fat diet after weaning, exposed to an unpredictable chronic stress at postnatal week (PW) 17 and sacrificed at PW20.
   Results: In PEE group, body weight presented a "catch-up growth" pattern, and the HPA axis exhibited a lower basal activity but an enhanced sensitivity to chronic stress, leading to increased levels of serum glucose, insulin, insulin resistant index, total cholesterol and low-density lipoprotein-cholesterol, and decreased levels of high-density lipoprotein-cholesterol. Furthermore, many lipid droplets and vacuolar degeneration were observed in the hypothalamus, pituitary gland and liver.
   Conclusions: PEE induces enhanced susceptibility to MS in adult offspring fed with high-fat diet, and the underlying mechanism involves a HPA axis-associated neuroendocrine metabolic programming alteration. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
C1 [Xia, L. P.; Shen, L.; Kou, H.; Zhang, B. J.; Zhang, L.; Wu, Y.; Li, X. J.; Xiong, J.; Yu, Y.; Wang, H.] Wuhan Univ, Basic Med Sch, Wuhan 430071, Hubei Province, Peoples R China.
   [Wang, H.] Hubei Prov Key Lab Dev Originated Disorder, Wuhan 430071, Peoples R China.
   [Xia, L. P.; Yu, Y.] Wuhan Univ, Renmin Hosp, Wuhan 430060, Peoples R China.
C3 Wuhan University; Wuhan University
RP Wang, H (corresponding author), Wuhan Univ, Basic Med Sch, Dept Pharmacol, Wuhan 430071, Hubei Province, Peoples R China.
EM wanghui19@whu.edu.cn
RI Zhang, Benjian/ABC-1130-2020; xia, liping/GQP-8833-2022; Shen,
   Lang/GQP-8556-2022; Wang, Hui/AAD-8788-2020
FU National Natural Science Foundation of China [30830112, 81072709,
   81220108026, 81300984]; Chinese Ministry of Education [V200801];
   National Science & Technology Pillar Program of China [2013BAI12B01-3]
FX This work was supported by grants from the National Natural Science
   Foundation of China (Nos. 30830112, 81072709, 81220108026 and 81300984),
   the Key Grant Project of the Chinese Ministry of Education (No. V200801)
   and the National Science & Technology Pillar Program of China (No.
   2013BAI12B01-3).
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NR 71
TC 53
Z9 63
U1 0
U2 15
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0378-4274
EI 1879-3169
J9 TOXICOL LETT
JI Toxicol. Lett.
PD APR 7
PY 2014
VL 226
IS 1
BP 98
EP 105
DI 10.1016/j.toxlet.2014.01.023
PG 8
WC Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Toxicology
GA AC3HX
UT WOS:000332409000013
PM 24472613
DA 2025-06-11
ER

PT J
AU Xue, P
   Hou, YY
   Chen, YY
   Yang, B
   Fu, JQ
   Zheng, HZ
   Yarborough, K
   Woods, CG
   Liu, DX
   Yamamoto, M
   Zhang, Q
   Andersen, ME
   Pi, JB
AF Xue, Peng
   Hou, Yongyong
   Chen, Yanyan
   Yang, Bei
   Fu, Jingqi
   Zheng, Hongzhi
   Yarborough, Kathy
   Woods, Courtney G.
   Liu, Dianxin
   Yamamoto, Masayuki
   Zhang, Qiang
   Andersen, Melvin E.
   Pi, Jingbo
TI Adipose Deficiency of Nrf2 in ob/ob Mice Results in
   Severe Metabolic Syndrome
SO DIABETES
LA English
DT Article
ID DIET-INDUCED OBESITY; IMPROVED INSULIN-SENSITIVITY; PPAR-GAMMA;
   ADIPOCYTE DIFFERENTIATION; OXIDATIVE STRESS; TISSUE EXPANDABILITY;
   TRANSCRIPTION; FAT; ADIPOGENESIS; CELL
AB Nuclear factor E2-related factor 2 (Nrf2) is a transcription factor that functions as a master regulator of the cellular adaptive response to oxidative stress. Our previous studies showed that Nrf2 plays a critical role in adipogenesis by regulating expression of CCAAT/enhancer-binding protein beta and peroxisome proliferator-activated receptor gamma. To determine the role of Nrf2 in the development of obesity and associated metabolic disorders, the incidence of metabolic syndrome was assessed in whole-body or adipocyte-specific Nrf2-knockout mice on a leptin-deficient ob/ob background, a model with an extremely positive energy balance. On the ob/ob background, ablation of Nrf2, globally or specifically in adipocytes, led to reduced white adipose tissue (WAT) mass, but resulted in art even more severe metabolic syndrome with aggravated insulin resistance, hyperglycemia, and hypertriglyceridemia. Compared with wild-type mice, WAT of ob/ob mice expressed substantially higher levels of many genes related to antioxidant response, inflammation, adipogenesis, lipogenesis, glucose uptake, and lipid transport. Absence of Nrf2 in WAT resulted in reduced expression of most of these factors at mRNA or protein levels. Our findings support a novel role for Nrf2 in regulating adipose development and function, by which Nrf2 controls the capacity of WAT expansion and insulin sensitivity and maintains glucose and lipid homeostasis. Diabetes 62:845-854, 2013
C1 [Xue, Peng; Hou, Yongyong; Chen, Yanyan; Yang, Bei; Fu, Jingqi; Zheng, Hongzhi; Yarborough, Kathy; Woods, Courtney G.; Zhang, Qiang; Andersen, Melvin E.; Pi, Jingbo] Hamner Inst Hlth Sci, Inst Chem Safety Sci, Res Triangle Pk, NC USA.
   [Chen, Yanyan; Zheng, Hongzhi] China Med Univ, Sch Clin Sci 1, Shenyang, Peoples R China.
   [Yang, Bei] China Med Univ, Coll Basic Med Sci, Shenyang, Peoples R China.
   [Liu, Dianxin] Sanford Burnham Med Res Inst, Metab Signaling & Dis Program, Orlando, FL USA.
   [Yamamoto, Masayuki] Tohoku Univ, Dept Med Biochem, Grad Sch Med, Sendai, Miyagi 980, Japan.
C3 The Hamner Institutes for Health Sciences; China Medical University;
   China Medical University; Sanford Burnham Prebys Medical Discovery
   Institute; Tohoku University
RP Pi, JB (corresponding author), Hamner Inst Hlth Sci, Inst Chem Safety Sci, Res Triangle Pk, NC USA.
EM jpi@thehamner.org
RI xue, peng/K-4159-2015; Yamamoto, Masayuki/A-4873-2010; Andersen,
   Melvin/S-6646-2019; PI, JINGBO/GWC-2514-2022; Liu, Dianxin/O-5053-2018
OI Andersen, Melvin/0000-0002-3894-4811; Liu, Dianxin/0000-0003-2282-7386;
   Fu, Jingqi/0000-0003-3871-428X; pi, Jingbo/0000-0003-0227-8041
FU National Institutes of Health [DK-76788, ES016005]; DOW Chemical
   Company; Unilever; American Chemistry Council
FX This work was supported in part by the National Institutes of Health
   Grants DK-76788 (to J.P.) and ES016005 (to J.P.). M.E.A. received some
   funding from DOW Chemical Company and Unilever. P.X., Y.H., Y.C., B.Y.,
   J.F., H.Z., C.G.W., K.Y., Q.Z., M.E.A., and J.P. are employees of The
   Hamner Institutes for Health Sciences. The Hamner is a 501(c)3
   not-for-profit organization that has a diverse research portfolio that
   includes funding from the American Chemistry Council, a trade
   association that represents chemical manufacturers. No other potential
   conflicts of interest relevant to this article were reported.
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NR 47
TC 138
Z9 153
U1 0
U2 27
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0012-1797
J9 DIABETES
JI Diabetes
PD MAR
PY 2013
VL 62
IS 3
BP 845
EP 854
DI 10.2337/db12-0584
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 098NQ
UT WOS:000315556400028
PM 23238296
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Cortés-Camacho, F
   Zambrano-Vásquez, OR
   Aréchaga-Ocampo, E
   Castaneda-Sánchez, JI
   Gonzaga-Sánchez, JG
   Sánchez-Gloria, JL
   Sánchez-Lozada, LG
   Osorio-Alonso, H
AF Cortes-Camacho, Fernando
   Zambrano-Vasquez, Oscar Rene
   Arechaga-Ocampo, Elena
   Castaneda-Sanchez, Jorge Ismael
   Gonzaga-Sanchez, Jose Guillermo
   Sanchez-Gloria, Jose Luis
   Sanchez-Lozada, Laura Gabriela
   Osorio-Alonso, Horacio
TI Sodium-Glucose Cotransporter Inhibitors: Cellular Mechanisms Involved in
   the Lipid Metabolism and the Treatment of Chronic Kidney Disease
   Associated with Metabolic Syndrome
SO ANTIOXIDANTS
LA English
DT Review
DE metabolic syndrome; obesity; hypertension; insulin resistance;
   dyslipidemia; lipid metabolism; lipotoxicity; oxidative stress; chronic
   kidney disease; sodium-glucose cotransporter 2 inhibitors
ID INSULIN-RESISTANCE; MEXICAN ADULTS; ADIPOSE-TISSUE; IN-VIVO; PREVALENCE;
   INFLAMMATION; EXPRESSION; OBESITY; ACID; INJURY
AB Metabolic syndrome (MetS) is a multifactorial condition that significantly increases the risk of cardiovascular disease and chronic kidney disease (CKD). Recent studies have emphasized the role of lipid dysregulation in activating cellular mechanisms that contribute to CKD progression in the context of MetS. Sodium-glucose cotransporter 2 inhibitors (SGLT2i) have demonstrated efficacy in improving various components of MetS, including obesity, dyslipidemia, and insulin resistance. While SGLT2i have shown cardioprotective benefits, the underlying cellular mechanisms in MetS and CKD remain poorly studied. Therefore, this review aims to elucidate the cellular mechanisms by which SGLT2i modulate lipid metabolism and their impact on insulin resistance, mitochondrial dysfunction, oxidative stress, and CKD progression. We also explore the potential benefits of combining SGLT2i with other antidiabetic drugs. By examining the beneficial effects, molecular targets, and cytoprotective mechanisms of both natural and synthetic SGLT2i, this review provides a comprehensive understanding of their therapeutic potential in managing MetS-induced CKD. The information presented here highlights the significance of SGLT2i in addressing the complex interplay between metabolic dysregulation, lipid metabolism dysfunction, and renal impairment, offering clinicians and researchers a valuable resource for developing improved treatment strategies and personalized approaches for patients with MetS and CKD.
C1 [Cortes-Camacho, Fernando; Zambrano-Vasquez, Oscar Rene] Univ Autonoma Metropolitana, Ciencias Biol & Salud, Mexico City 04960, Mexico.
   [Cortes-Camacho, Fernando; Zambrano-Vasquez, Oscar Rene; Gonzaga-Sanchez, Jose Guillermo; Sanchez-Lozada, Laura Gabriela; Osorio-Alonso, Horacio] Inst Nacl Cardiol Ignacio Chavez, Dept Fisiopatol Cardiorenal, Mexico City 14080, Mexico.
   [Arechaga-Ocampo, Elena] Univ Autonoma Metropolitana Cuajimalpa, Dept Ciencias Nat, Mexico City 05348, Mexico.
   [Castaneda-Sanchez, Jorge Ismael] Univ Autonoma Metropolitana, Dept Sistemas Biol, Unidad Xochimilco, Mexico City 04960, Mexico.
   [Sanchez-Gloria, Jose Luis] Rush Univ, Med Ctr, Dept Internal Med, Div Nephrol, Chicago, IL 60612 USA.
C3 Universidad Autonoma Metropolitana - Mexico; National Institute of
   Cardiology - Mexico; Universidad Autonoma Metropolitana - Mexico;
   University Autonoma Metropolitana Cuajimalpa; Universidad Autonoma
   Metropolitana - Mexico; Rush University
RP Osorio-Alonso, H (corresponding author), Inst Nacl Cardiol Ignacio Chavez, Dept Fisiopatol Cardiorenal, Mexico City 14080, Mexico.
EM fcortesc1700@alumno.ipn.mx; renezambrano2513@gmail.com;
   earechaga@cua.uam.mx; jcastanedas@correo.xoc.uam.mx;
   jose.gonzaga@cardiologia.org.mx; jose_sanchez@rush.edu;
   laura.sanchez@cardiologia.org.mx; horace_33@yahoo.com.mx
RI CASTAÑEDA-SANCHEZ, JORGE/AAZ-2523-2021; Arechaga-Ocampo,
   Elena/AAG-8756-2021; Alonso, Horacio/T-3946-2019; Sanchez-Lozada,
   Laura/AAS-2104-2021
OI Zambrano Vasquez, Oscar Rene/0009-0005-6645-9054; CASTANEDA-SANCHEZ,
   JORGE ISMAEL/0000-0002-4323-4988; Arechaga-Ocampo,
   Elena/0000-0002-0787-5593; Osorio Alonso, Horacio/0000-0002-9238-4202;
   Cortes, Fernando/0009-0006-6697-546X
FU Instituto Nacional de Cardiologa Ignacio Chvez
FX The financing for this research as well as the publishing in open access
   were covered by the Instituto Nacional de Cardiologia Ignacio Chavez.
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NR 143
TC 5
Z9 5
U1 5
U2 8
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD JUL
PY 2024
VL 13
IS 7
AR 768
DI 10.3390/antiox13070768
PG 23
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA ZP5J8
UT WOS:001276510400001
PM 39061837
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Swart, PC
   van den Heuvel, LL
   Lewis, CM
   Seedat, S
   Hemmings, SMJ
AF Swart, Patricia C.
   van den Heuvel, Leigh L.
   Lewis, Cathryn M.
   Seedat, Soraya
   Hemmings, Sian M. J.
TI A Genome-Wide Association Study and Polygenic Risk Score Analysis of
   Posttraumatic Stress Disorder and Metabolic Syndrome in a South African
   Population
SO FRONTIERS IN NEUROSCIENCE
LA English
DT Article
DE polygenic risk scores; GWAS; PTSD; metabolic syndrome; PARK2
ID PTSD; COMPONENTS
AB Posttraumatic stress disorder (PTSD) is a trauma-related disorder that frequently co-occurs with metabolic syndrome (MetS). MetS is characterized by obesity, dyslipidemia, and insulin resistance. To provide insight into these co-morbidities, we performed a genome-wide association study (GWAS) meta-analysis to identify genetic variants associated with PTSD, and determined if PTSD polygenic risk scores (PRS) could predict PTSD and MetS in a South African mixed-ancestry sample. The GWAS meta-analysis of PTSD participants (n = 260) and controls (n = 343) revealed no SNPs of genome-wide significance. However, several independent loci, as well as five SNPs in the PARK2 gene, were suggestively associated with PTSD (p < 5 x 10(-6)). PTSD-PRS was associated with PTSD diagnosis (Nagelkerke's pseudo R-2 = 0.0131, p = 0.00786), PTSD symptom severity [as measured by CAPS-5 total score (R-2 = 0.00856, p = 0.0367) and PCL-5 score (R-2 = 0.00737, p = 0.0353)], and MetS (Nagelkerke's pseudo R-2 = 0.00969, p = 0.0217). These findings suggest an association between PTSD and PARK2, corresponding with results from the largest PTSD-GWAS conducted to date. PRS analysis suggests that genetic variants associated with PTSD are also involved in the development of MetS. Overall, the results contribute to a broader goal of increasing diversity in psychiatric genetics.
C1 [Swart, Patricia C.; van den Heuvel, Leigh L.; Seedat, Soraya; Hemmings, Sian M. J.] Univ Stellenbosch, Dept Psychiat, Fac Med & Hlth Sci, Stellenbosch, South Africa.
   [Swart, Patricia C.; van den Heuvel, Leigh L.; Seedat, Soraya; Hemmings, Sian M. J.] Stellenbosch Univ, South African Med Res Council, Genom Brain Disorders Res Unit, Fac Med & Hlth Sci, Cape Town, South Africa.
   [Lewis, Cathryn M.] Kings Coll London, Social Genet & Dev Psychiat Ctr, London, England.
C3 Stellenbosch University; Stellenbosch University; South African Medical
   Research Council; University of London; King's College London
RP Swart, PC (corresponding author), Univ Stellenbosch, Dept Psychiat, Fac Med & Hlth Sci, Stellenbosch, South Africa.; Swart, PC (corresponding author), Stellenbosch Univ, South African Med Res Council, Genom Brain Disorders Res Unit, Fac Med & Hlth Sci, Cape Town, South Africa.
EM patswart@sun.ac.za
RI Lewis, Cathryn/M-8766-2019; van den Heuvel, Leigh/AGV-5481-2022;
   Hemmings, Sian/ABF-9676-2022; Lewis, Cathryn/A-5225-2010
OI van den Heuvel, Leigh/0000-0003-3884-4754; Swart,
   Patricia/0000-0001-8249-6895; Lewis, Cathryn/0000-0002-8249-8476;
   Seedat, Soraya/0000-0002-5118-786X
FU South African Medical Research Council (SAMRC) from the South African
   National Treasury under its Economic Competitiveness and Support Package
   [MRC-RFA-IFSP-01-2013/SHARED ROOTS]; SAMRC Genomics of Brain Disorders
   Unit - SAMRC; South African Research Chairs Initiative in PTSD -
   Department of Science and Innovation; SAMRC through its Division of
   Research Capacity Development under the SAMRC clinician researcher (M.D.
   Ph.D.) scholarship program - South African National Treasury; National
   Institute for Health Research (NIHR) Biomedical Research Centre at South
   London and Maudsley NHS Foundation Trust; King's College London;
   National Research Foundation [120682]; Royal Society; Academy of Finland
   (AKA) [120682] Funding Source: Academy of Finland (AKA)
FX Research reported in this publication was supported by the South African
   Medical Research Council (SAMRC) for the "Shared Roots" Flagship Project
   (Grant no. MRC-RFA-IFSP-01-2013/SHARED ROOTS) through funding received
   from the South African National Treasury under its Economic
   Competitiveness and Support Package. SS and SH were supported by the
   SAMRC Genomics of Brain Disorders Unit funded by the SAMRC and the South
   African Research Chairs Initiative in PTSD funded by the Department of
   Science and Innovation and National Research Foundation. The work by LH
   was supported by funding from the SAMRC through its Division of Research
   Capacity Development under the SAMRC clinician researcher (M.D. Ph.D.)
   scholarship program, funded by the South African National Treasury. CL
   was part-funded by the National Institute for Health Research (NIHR)
   Biomedical Research Centre at South London and Maudsley NHS Foundation
   Trust and King's College London. PS was supported by the National
   Research Foundation (Grant number: 120682). The contents of this
   research article are solely the responsibility of the authors and do not
   necessarily represent the official views of the funders. PS, CL, and SH
   would like to acknowledge the Royal Society Newton Mobility Grant
   (2018/2019) for the assistance in establishing the collaboration between
   Stellenbosch University and King's College London.
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NR 61
TC 6
Z9 6
U1 0
U2 12
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1662-453X
J9 FRONT NEUROSCI-SWITZ
JI Front. Neurosci.
PD JUN 10
PY 2021
VL 15
AR 677800
DI 10.3389/fnins.2021.677800
PG 11
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA SX2JO
UT WOS:000665037000001
PM 34177453
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Khalfa, A
   Tiali, A
   Zemour, L
   Fatah, A
   Mekki, K
AF Khalfa, Ali
   Tiali, Amina
   Zemour, Lakhdar
   Fatah, Azzedine
   Mekki, Khedidja
TI Prevalence of metabolic syndrome and its association with lifestyle and
   cardiovascular biomarkers among postmenopausal women in western Algeria
SO INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
LA English
DT Article
DE Dyslipidemia; Energy expenditure; Food consumption; Inflammation;
   Lifestyle; Metabolic syndrome; Oxidative status; Postmenopausal women
ID PHYSICAL-ACTIVITY; DENSITY; OBESITY
AB Objective: To evaluate the prevalence of metabolic syndrome (MetS), its components, and their relationship with lifestyle, inflammation, and oxidative stress among postmenopausal Algerian women.
   Methods: A prospective cross-sectional survey was conducted among postmenopausal women at a clinic in Oran, Algeria, from March 1 to June 28, 2015. A diagnosis of MetS was made using the National Cholesterol Education Program Adult Treatment Panel III guidelines. Demographic, clinical, metabolic, inflammatory, dietary, and energy variables were assessed.
   Results: Among 183 participants, 106 (57.9%) were diagnosed with MetS. Components of MetS included hypertension (n=144, 78.7%), hyperglycemia (n=135, 73.8%), hypertriglyceridemia (n=125, 68.3%), abdominal obesity (n=123, 67.2%), and low levels of high-density lipoprotein cholesterol (n=121, 66.1%). Although daily energy expenditure was similar among the women with or without MetS, total energy intake was increased in the group with MetS (P<0.001). The following measures were also increased among women with MetS: saturated fatty acid intake (P<0.001), C-reactive protein (P=0.051), thiobarbituric acid reactive substances (P<0.001), and carbonyls (P<0.001). By contrast, decreased monounsaturated fatty acid intake (P=0.024) and catalase activity (P<0.001) were observed in this group.
   Conclusion: Postmenopausal status could predict MetS, with inflammation and oxidative stress arising from an unhealthy lifestyle potentially increasing cardiovascular risk.
C1 [Khalfa, Ali; Tiali, Amina; Mekki, Khedidja] Univ Oran1 Ahmed Benbella, Dept Biol, Oran, Algeria.
   [Zemour, Lakhdar] Univ Oran1, Serv Epidemiol, Etab Hosp, Oran, Algeria.
   [Fatah, Azzedine] Direct Sante & Populat Oran, Oran, Algeria.
RP Mekki, K (corresponding author), Univ Oran1 Ahmed Benbella, Fac Sci Nat & Vie, Lab Nutr Clin & Metab, Oran, Algeria.
EM khmekki@hotmail.com
RI khalfa, ali/GYV-3672-2022; MEKKI, Khedidja/K-3832-2016
OI khalfa, Ali/0009-0009-5314-6605; MEKKI, Khedidja/0000-0001-8783-3088;
   ZEMOUR, LAKHDAR/0000-0002-5730-8044
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NR 27
TC 16
Z9 16
U1 0
U2 9
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0020-7292
EI 1879-3479
J9 INT J GYNECOL OBSTET
JI Int. J. Gynecol. Obstet.
PD AUG
PY 2017
VL 138
IS 2
BP 201
EP 206
DI 10.1002/ijgo.12206
PG 6
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA FA0AQ
UT WOS:000405093300013
PM 28494104
DA 2025-06-11
ER

PT J
AU Pozza, RD
   Bechtold, S
   Putzker, S
   Bonfig, W
   Netz, H
   Schwarz, HP
AF Pozza, RD
   Bechtold, S
   Putzker, S
   Bonfig, W
   Netz, H
   Schwarz, HP
TI Young adults born small for gestational age: Is reduced baroreceptor
   sensitivity a risk factor for hypertension?
SO CLINICAL CARDIOLOGY
LA English
DT Article
DE beat-to-beat blood pressure; baroreceptor sensitivity; cardiovascular
   risk
ID CATCH-UP GROWTH; CORONARY-HEART-DISEASE; INSULIN SENSITIVITY;
   BLOOD-PRESSURE; IN-UTERO; LIFE; ADOLESCENCE; MANAGEMENT; CHILDHOOD;
   SECRETION
AB Background: Adults born small for gestational age (SGA) are at increased risk for the metabolic syndrome and cardiovascular disease.
   Hypothesis: Impaired short-term blood pressure regulation may contribute to the development of hypertension in patients born SGA.
   Methods: In all, 43 patients born SGA (18 female, age 19.4 +/- 0.3 years) were evaluated by beat-to-beat blood pressure and heart rate registration during rest and mental and orthostatic stress. The study group was divided into Group I with normal resting blood pressure (n = 32) and Group 2 with slightly elevated blood pressure (n = 11). Baroreceptor sensitivity (BRS) was calculated. Fasting insulin as well as lipid levels were correlated with hemodynamic parameters.
   Results: Eleven of the 43 study patients (25%) had a slightly elevated resting systolic blood pressure (SBP) rising during mental and orthostatic stress. Body mass index (BMI) and fasting insulin levels correlated strongly with SBP in Group 2. Baroreceptor sensitivity was lower in Group 2 at rest (p < 0.05).
   Conclusions: Three components of metabolic syndrome (elevated BP, high BMI, elevated insulin levels) correlate strongly in young adolescents born SGA; BRS is reduced in prehypertensive patients. Close follow-up is warranted during adult life as they are predisposed for developing a metabolic syndrome with elevated cardiovascular risk.
C1 Univ Munich, Dept Pediat Cardiol, Univ Childrens Hosp, D-80336 Munich, Germany.
   Univ Munich, Dept Pediat Endocrinol & Diabetol, Univ Childrens Hosp, D-80336 Munich, Germany.
C3 University of Munich; University of Munich
RP Univ Munich, Dept Pediat Cardiol, Univ Childrens Hosp, Lindwurmstr 4, D-80336 Munich, Germany.
EM Robert.DallaPozza@med.uni-muenchen.de
RI Pozza, Robert/E-8711-2018
CR [Anonymous], BLOOD PRESSURE HEART
   Arends NJT, 2005, CLIN ENDOCRINOL, V62, P44, DOI 10.1111/j.1365-2265.2004.02171.x
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NR 29
TC 8
Z9 9
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0160-9289
EI 1932-8737
J9 CLIN CARDIOL
JI Clin. Cardiol.
PD MAY
PY 2006
VL 29
IS 5
BP 215
EP 218
DI 10.1002/clc.4960290509
PG 4
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 039CW
UT WOS:000237278900008
PM 16739394
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Park, HM
   Han, TH
   Kwon, YJ
   Lee, JH
AF Park, Hye-Min
   Han, Tea-Hwa
   Kwon, Yu-Jin
   Lee, Jun-Hyuk
TI Oxidative balance score inversely associated with the prevalence and
   incidence of metabolic syndrome: analysis of two studies of the Korean
   population
SO FRONTIERS IN NUTRITION
LA English
DT Article
DE oxidative balance score; pro-oxidant; antioxidant; metabolic syndrome;
   Korean Genome and Epidemiology Study
ID NUTRITION EXAMINATION SURVEY; NATIONAL-HEALTH; RISK; STRESS;
   REPRODUCIBILITY; QUESTIONNAIRE; HYPERTENSION; INFLAMMATION; VALIDATION;
   VALIDITY
AB Background: Pro-oxidant/antioxidant imbalances leading to chronic inflammation and insulin resistance can contribute to the development of metabolic syndrome (MetS). Oxidative Balance Score (OBS), a comprehensive measure of exposure to pro- and anti-oxidants, represents an individual's total oxidative balance. This study aimed to evaluate the association between OBS and MetS using two large datasets.
   Methods: We analyzed data from 2,735 adults older than 19 years from the 2021 Korean National Health and Nutritional Examination Survey (KNHANES) and 5,807 adults aged 40-69 years from the Korean Genome and Epidemiology Study (KoGES). In each dataset, OBS was categorized into sex-specific tertiles (T).
   Results: In KNHANES, the odds ratios and 95% confidence intervals for prevalent MetS in T3, compared to T1, were 0.44 (0.29-0.65) in men and 0.34 (0.23-0.50) in women after adjusting for confounders. In KoGES, the hazard ratios and 95% confidence intervals for incident MetS in T3, compared to T1, were 0.56 (0.480.65) in men and 0.63 (0.55-0.73) in women after adjusting for confounders.
   Conclusion: OBS appears to be inversely related to MetS, which suggests that adopting lifestyle behaviors that decrease oxidative stress could be an important preventive strategy for MetS.
C1 [Park, Hye-Min] Natl Hlth Insurance Serv Ilsan Hosp, Primary Care Res Ctr, Goyang, South Korea.
   [Han, Tea-Hwa] Yonsei Univ, Hlth IT Ctr, Severance Hosp, Seoul, South Korea.
   [Kwon, Yu-Jin] Yonsei Univ, Coll Med, Yongin Severance Hosp, Dept Family Med, Yongin, South Korea.
   [Lee, Jun-Hyuk] Eulji Univ, Sch Med, Nowon Eulji Med Ctr, Dept Family Med, Seoul, South Korea.
   [Lee, Jun-Hyuk] Hanyang Univ, Dept Med, Sch Med, Seoul, South Korea.
C3 National Health Insurance Service; Yonsei University; Yonsei University
   Health System; Yonsei University; Yonsei University Health System; Eulji
   University; Hanyang University
RP Kwon, YJ (corresponding author), Yonsei Univ, Coll Med, Yongin Severance Hosp, Dept Family Med, Yongin, South Korea.; Lee, JH (corresponding author), Eulji Univ, Sch Med, Nowon Eulji Med Ctr, Dept Family Med, Seoul, South Korea.; Lee, JH (corresponding author), Hanyang Univ, Dept Med, Sch Med, Seoul, South Korea.
EM digda3@yuhs.ac; swpapa@eulji.ac.kr
RI Lee, Jun-Hyuk/KOC-2534-2024; Kwon, Yu-Jin/ACB-8082-2022
OI Lee, Jun-Hyuk/0000-0002-1007-1633; KWON, YUJIN/0000-0002-9021-3856
FU This research was financially supported by the Ministry of SMEs and
   Startups and Korea Technology and Promotion Agency for SMEs (TIPA)
   through the Regional Specialized Industry Development Plus Program
   (Grant number: S3370378).; Ministry of SMEs; Korea Technology and
   Promotion Agency for SMEs (TIPA) through the Regional Specialized
   Industry Development Plus Program;  [S3370378]
FX Data in this study were obtained from 2021 Korea National Health and
   Nutrition Examination Survey (KNHANES) and the Korean Genome and
   Epidemiology Study (4851-302), the National Research Institute of
   Health, the Centers for Disease Control and Prevention, and the Ministry
   for Health and Welfare of the Republic of Korea.r This research was
   financially supported by the Ministry of SMEs and Startups and Korea
   Technology and Promotion Agency for SMEs (TIPA) through the Regional
   Specialized Industry Development Plus Program (Grant number: S3370378).
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NR 49
TC 9
Z9 9
U1 0
U2 0
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD AUG 16
PY 2023
VL 10
AR 1226107
DI 10.3389/fnut.2023.1226107
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA Q5IU7
UT WOS:001057864200001
PM 37654473
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Nogales, F
   Ojeda, ML
   Serrano, A
   Rua, RM
   Carreras, O
AF Nogales, F.
   Ojeda, M. L.
   Serrano, A.
   Rua, R. M.
   Carreras, O.
TI Metabolic syndrome during gestation and lactation: An important renal
   problem in dams. selenium renal clearance
SO JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
LA English
DT Article
DE Metabolic syndrome; Selenium; Renal damage; Systolic blood pressure
ID OXIDATIVE STRESS; PROLACTIN INHIBITION; RATS; IMPROVES; LEPTIN; INJURY
AB Background: Metabolic syndrome (MS) in lactating dams leads to several cardiometabolic changes related to selenium (Se) status and selenoproteins expression which produce hypertension. However, little is known about the state of these dams' kidney functions and their Se deposits.
   Methods: Two experimental groups of dam rats were used: control (Se: 0.1 ppm) and MS (Fructose 65 % and Se: 0.1 ppm). At the end of lactation (21d postpartum) kidney weight and protein content, Se deposits, and the activity of the antioxidant selenoprotein glutathione peroxidase (GPx) were measured in dams. Kidney functional parameters: albuminuria, creatinine clearance, serum aldosterone and uric acid levels and water and electrolyte (Na+ and K+) balance were also evaluated. Systolic blood pressure (SBP) was measured.
   Results: In MS dams at the end of lactation Se deposits and GPx activity are higher in the kidney; however, lipid renal peroxidation appears, relative Se clearance increases, and the dams have lost Se by urine. MS dams have polyuria and polydipsia, high uric acid serum levels, albuminuria and high creatinine clearance, implying glomerular renal malfunction with protein loss. They also present hypernatremia, hypokalemia and hyperaldosteronemia, leading to high SBP; however, a natriuretic process is taking place.
   Conclusion: Since these alterations appear, at least in part, to be related to oxidative stress in renal cells, Se supplementation could be beneficial to avoiding greater lipid renal oxidation during lactation.
C1 [Nogales, F.; Ojeda, M. L.; Serrano, A.; Carreras, O.] Univ Seville, Fac Pharm, Dept Physiol, C Prof Garcia Gonzalez 2, Seville 41012, Spain.
   [Rua, R. M.] Univ Fernando Pessoa, Fac Hlth Sci, Porto, Portugal.
C3 University of Sevilla; Universidade Fernando Pessoa
RP Ojeda, ML (corresponding author), Univ Seville, Fac Pharm, Dept Physiol, C Prof Garcia Gonzalez 2, Seville 41012, Spain.
EM ojedamuri11@us.es
RI Nogales, F/B-8562-2019; Rua, Rui/AGE-0037-2022; Ojeda, Luisa/B-8571-2019
OI Nogales, Fatima/0000-0003-4844-2740; Maria Luisa, Ojeda
   Murillo/0000-0002-9160-2749; Rua, Rui/0000-0002-0227-9573
FU Andalusian Regional Government; Plan Propio from the University of
   Seville
FX This work was supported by the Andalusian Regional Government in its
   support of CTS-193 research group. We also acknowledge the support of
   the Plan Propio from the University of Seville to promoted research and
   transference activities.
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NR 48
TC 2
Z9 2
U1 0
U2 6
PU ELSEVIER GMBH
PI MUNICH
PA HACKERBRUCKE 6, 80335 MUNICH, GERMANY
SN 0946-672X
EI 1878-3252
J9 J TRACE ELEM MED BIO
JI J. Trace Elem. Med. Biol.
PD MAR
PY 2021
VL 64
AR 126709
DI 10.1016/j.jtemb.2020.126709
PG 6
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA PY7GX
UT WOS:000612211200010
PM 33387739
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Karaman, ME
   Tektemur, A
AF Karaman, Muhammed Emre
   Tektemur, Ahmet
TI The therapeutic effects of distinct exercise types on metabolic
   syndrome-induced reproductive system impairment in male rats: Potential
   contribution of mitochondria-related genes
SO ANDROLOGIA
LA English
DT Article
DE exercise therapy; metabolic syndrome; mitochondria; oxidative stress;
   reproductive system
ID HORMONE-BINDING GLOBULIN; OXIDATIVE STRESS; AEROBIC EXERCISE;
   TESTOSTERONE; DYSFUNCTION; SEX; BEVERAGES; MARKERS; IMPACT
AB A sedentary lifestyle and high fructose dietary habits cause diseases, such as metabolic syndrome (MS). The study was aimed to investigate the potential ameliorative effects of different exercise interventions on high fructose-induced MS-mediated reproductive system disruption of male rats. Rats were divided into four groups (n = 6): Control, MS, MS+aerobic exercise (AE) and MS+anaerobic exercise (ANE). MS was induced by using tap water containing 30% fructose for 8 weeks. After the induction of MS, AE/ANE implementations were started for 6 weeks. Testis tissue and serum samples of rats were stored for biochemical and molecular analyses. Serum total antioxidant status level increased in the MS+AE group compared to all groups. Also, serum total oxidant status level, which increased by MS, decreased with AE, but not altered with ANE. Moreover, MS markedly decreased serum luteinizing hormone, but not changed the follicle-stimulating hormone. However, serum hormone levels were similar to the control group in both MS+AE and MS+ANE groups. MS upregulated mitochondria-related genes' mRNA expressions (MFN2, PGC1A, PPARG, PARP2 and TXNL4B). These increases, except for PPARG, were normalized with both exercise types. These results revealed that mitochondria-related genes may have a crucial role in MS-mediated male reproductive impairment and therapeutic effects of exercises.
C1 [Karaman, Muhammed Emre] Firat Univ, Fac Sport Sci, Dept Coach Training, Elazig, Turkey.
   [Tektemur, Ahmet] Firat Univ, Fac Med, Dept Med Biol, Elazig, Turkey.
C3 Firat University; Firat University
RP Tektemur, A (corresponding author), Firat Univ, Fac Med, Dept Med Biol, Elazig, Turkey.
EM atektemur@firat.edu.tr
RI Tektemur, Ahmet/V-8755-2018; KARAMAN, Muhammed Emre/W-4999-2018
OI KARAMAN, Muhammed Emre/0000-0003-0800-8093
FU Firat University Scientific Research Projects Unit (FUBAP)
FX The study was supported by Firat University Scientific Research Projects
   Unit (FUBAP).
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NR 40
TC 2
Z9 2
U1 1
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0303-4569
EI 1439-0272
J9 ANDROLOGIA
JI Andrologia
PD MAY
PY 2022
VL 54
IS 4
AR e14391
DI 10.1111/and.14391
EA FEB 2022
PG 7
WC Andrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 0E9UE
UT WOS:000750906300001
PM 35118694
OA gold
DA 2025-06-11
ER

PT J
AU de Oliveira, MS
   Pellenz, FM
   de Souza, BM
   Crispim, D
AF de Oliveira, Mayara Souza
   Pellenz, Felipe Mateus
   de Souza, Bianca Marmontel
   Crispim, Daisy
TI Blueberry Consumption and Changes in Obesity and Diabetes Mellitus
   Outcomes: A Systematic Review
SO METABOLITES
LA English
DT Review
DE Vaccinium spp; blueberry; bilberry; obesity; metabolic syndrome;
   diet-induced obesity; systematic review
ID HIGH-FAT-DIET; NITRIC-OXIDE SYNTHASE; OXIDATIVE STRESS; METABOLIC
   SYNDROME; INSULIN-RESISTANCE; GENE-EXPRESSION; DOUBLE-BLIND; ANTIOXIDANT
   ACTIVITY; BIOACTIVE COMPOUNDS; BERRY ANTHOCYANINS
AB Low-grade inflammation and oxidative stress are key mechanisms involved in obesity and related disorders. Polyphenols from blueberry (BB) and bilberries (BiB) might protect against oxidative damage and inflammation. To summarize the effects of BiB or BB consumption in parameters related to obesity and its comorbidities, a search of the literature was performed in PubMed, Embase, and Cochrane Library repositories to identify all studies that evaluated associations of whole BB or BiB with obesity and associated disorders. Thirty-one studies were eligible for inclusion in this review: eight clinical trials and 23 animal studies. In humans, BB consumption only consistently decreased oxidative stress and improved endothelial function. In rodents, BB or BiB consumption caused positive effects on glucose tolerance, nuclear factor-kappa B (Nf-kappa b) activity, oxidative stress, and triglyceride (TG) content in the liver and hepatic steatosis. The high content of anthocyanins present in BB and BiB seems to attenuate oxidative stress. The decrease in oxidative stress may have a positive impact on glucose tolerance and endothelial function. Moreover, in rodents, these berries seem to protect against hepatic steatosis, through the decreased accumulation of hepatic TGs. BB and BiB might also attenuate inflammation by decreasing Nf-kappa b activity and immune cell recruitment into the adipose tissue.
C1 [de Oliveira, Mayara Souza; Pellenz, Felipe Mateus; Crispim, Daisy] Hosp Clin Porto Alegre, Endocrinol Div, BR-90035903 Porto Alegre, RS, Brazil.
   [de Oliveira, Mayara Souza; Pellenz, Felipe Mateus; de Souza, Bianca Marmontel; Crispim, Daisy] Univ Fed Rio Grande, Fac Med, Grad Program Med Sci Endocrinol, BR-90010150 Porto Alegre, RS, Brazil.
   [de Souza, Bianca Marmontel] Univ Libre Bruxelles, Med Fac, ULB Ctr Diabet Res, B-1070 Brussels, Belgium.
C3 Hospital de Clinicas de Porto Alegre; Universidade Federal do Rio
   Grande; Universite Libre de Bruxelles
RP Crispim, D (corresponding author), Hosp Clin Porto Alegre, Endocrinol Div, BR-90035903 Porto Alegre, RS, Brazil.; Crispim, D (corresponding author), Univ Fed Rio Grande, Fac Med, Grad Program Med Sci Endocrinol, BR-90010150 Porto Alegre, RS, Brazil.
EM dcmoreira@hcpa.edu.br
RI Crispim, Daisy/R-5170-2019; Pellenz, Felipe/ISU-1395-2023
OI Crispim, Daisy/0000-0001-5095-9269
FU Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq);
   Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (Capes);
   Fundo de Incentivo a Pesquisa e Eventos (FIPE) at Hospital de Clinicas
   de Porto Alegre; CNPq; CAPES; FIPE; Hospital de Clinicas de Porto
   Alegre; Post-Graduation Program in Medical Sciences: Endocrinology,
   Univerdade Federal do Rio Grande do Sul
FX This study was funded by grants from the Conselho Nacional de
   Desenvolvimento Cientifico e Tecnologico (CNPq), Coordenacao de
   Aperfeicoamento de Pessoal de Nivel Superior (Capes), and Fundo de
   Incentivo a Pesquisa e Eventos (FIPE) at Hospital de Clinicas de Porto
   Alegre. D.C. and M.S.O are recipients of scholarships from CNPq, while
   F.M.P. is recipient of a scholarship from CAPES. APC was funded by FIPE,
   Hospital de Clinicas de Porto Alegre, and Post-Graduation Program in
   Medical Sciences: Endocrinology, Univerdade Federal do Rio Grande do
   Sul.
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NR 82
TC 9
Z9 9
U1 4
U2 26
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2218-1989
J9 METABOLITES
JI Metabolites
PD JAN
PY 2023
VL 13
IS 1
AR 19
DI 10.3390/metabo13010019
PG 20
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 8R0HR
UT WOS:000927578700001
PM 36676944
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Söderberg, M
   Eriksson, H
   Torén, K
   Bergström, G
   Andersson, E
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AF Soderberg, Mia
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   Andersson, Eva
   Rosengren, Annika
TI Psychosocial job conditions and biomarkers of cardiovascular disease: A
   cross-sectional study in the Swedish CArdioPulmonary bioImage Study
   (SCAPIS)
SO SCANDINAVIAN JOURNAL OF PUBLIC HEALTH
LA English
DT Article
DE Job demand-control; hypertension; cholesterol; coronary artery
   calcification; metabolic syndrome; cardiovascular disease
ID CORONARY-HEART-DISEASE; RISK-FACTORS; WORK STRESS; ARTERY CALCIUM;
   STRAIN; QUANTIFICATION; METAANALYSIS
AB Aims: The aim of this study was to investigate associations between psychosocial work exposure and the presence of biological and imaging biomarkers of cardiovascular disease. Methods: This cross-sectional study was conducted in a sub-cohort of the Swedish CArdioPulmonary bioImage Study (SCAPIS). Psychosocial exposure was evaluated with the job demand-control model, and analysed according to the standard categorization: high strain, active, passive and low strain (reference). Biomarkers (blood pressure, high-density lipoprotein (HDL) and low-density lipoprotein (LDL) cholesterol, coronary artery calcification (CAC) and metabolic syndrome) were measured, or derived through measurements, from clinical examinations. Gender-specific prevalence ratios (PRs) and 95% confidence intervals (CIs) were calculated with regression models and adjusted for age, education, smoking, physical activity, general life stress and body mass index (BMI). Results: The analyses included 3882 participants (52.5% women). High strain (high demands-low control) was linked to increased PR for low HDL cholesterol in women, adjusted for all covariates (PR 1.76; 95% CI 1.25-2.48). High strain was also related to moderately increased PR for metabolic syndrome in men, after adjustments for all covariates except BMI (PR 1.25; 95% CI 1.02-1.52). In addition, passive work (low demands-low control) was associated with diastolic hypertension in women (fully adjusted: PR 1.29; 95% CI 1.05-1.59). All relationships between psychosocial factors and LDL cholesterol or CAC (both genders), or hypertension (men), were non-significant. Conclusions: Poor psychosocial job conditions was associated with the presence of low HDL cholesterol and diastolic hypertension in women, and metabolic syndrome in men. These findings contribute to the knowledge of potential pathways between stressful work and coronary heart disease.
C1 [Soderberg, Mia; Eriksson, Helena; Toren, Kjell; Andersson, Eva] Univ Gothenburg, Sch Publ Hlth & Community Med, Occupat & Environm Med, Gothenburg, Sweden.
   [Eriksson, Helena; Toren, Kjell; Andersson, Eva] Sahlgrens Univ Hosp, Dept Occupat & Environm Med, Gothenburg, Sweden.
   [Bergstrom, Goran; Rosengren, Annika] Univ Gothenburg, Inst Med, Dept Mol & Clin Med, Gothenburg, Sweden.
C3 University of Gothenburg; Sahlgrenska University Hospital; University of
   Gothenburg
RP Söderberg, M (corresponding author), Univ Gothenburg, Sahlgrenska Acad, Occupat & Environm Med, Sch Publ Hlth & Community Med,Inst Med, Box 414, S-40530 Gothenburg, Sweden.
EM mia.soderberg@amm.gu.se
OI Soderberg, Mia/0000-0003-0662-6541
FU AFA Insurance [160334]; Swedish Heart-Lung Foundation; Knut and Alice
   Wallenberg Foundation; Swedish Research Council [2018-02527]; VINNOVA
   (Sweden's innovation agency); University of Gothenburg; Sahlgrenska
   University Hospital; Karolinska Institutet; Stockholm County Council;
   Linkoping University and University Hospital; Lund University; Skane
   University Hospital; Umea University and University Hospital; Uppsala
   University and University Hospital; Swedish Research Council
   [2018-02527] Funding Source: Swedish Research Council
FX This work was supported by AFA Insurance (grant number 160334). The main
   funding body of SCAPIS is the Swedish Heart-Lung Foundation. The study
   was also funded by the Knut and Alice Wallenberg Foundation, the Swedish
   Research Council (grant number 2018-02527) and VINNOVA (Sweden's
   innovation agency), the University of Gothenburg and Sahlgrenska
   University Hospital, Karolinska Institutet and Stockholm County Council,
   Linkoping University and University Hospital, Lund University and Skane
   University Hospital, Umea University and University Hospital, Uppsala
   University and University Hospital.
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NR 33
TC 2
Z9 2
U1 0
U2 4
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1403-4948
EI 1651-1905
J9 SCAND J PUBLIC HEALT
JI Scand. J. Public Health
PD AUG
PY 2023
VL 51
IS 6
BP 843
EP 852
AR 14034948211064097
DI 10.1177/14034948211064097
EA JAN 2022
PG 10
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA M4HP1
UT WOS:000740962000001
PM 34986695
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Yokozawa, T
   Kim, HJ
   Cho, EJ
AF Yokozawa, Takak
   Kim, Hyun Ju
   Cho, Eun Ju
TI Gravinol ameliorates high-fructose-induced metabolic syndrome through
   regulation of lipid metabolism and proinflammatory state in rats
SO JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
LA English
DT Article
DE gravinol; high fructose; metabolic syndrome; oxidative stress;
   proinflammatory state
ID ALPHA PPAR-ALPHA; INSULIN-RESISTANCE; GRAPE SEEDS;
   CARDIOVASCULAR-DISEASE; INDUCED HYPERTENSION; GENE-EXPRESSION;
   ADIPOSE-TISSUE; KAPPA-B; PROANTHOCYANIDIN; CHOLESTEROL
AB Using a rat model with fructose-induced metabolic syndrome, the effect of gravinol was investigated. Male Wistar rats were fed a 65% fructose diet and administered 10 or 20 mg of gravinol/kg of body weight/day for 2 weeks. High-level fructose feeding led to hyperglycemia, hyperlipidemia, hypertriglyceridemia, and hypertension. On the other hand, the administration of gravinol significantly lowered serum glucose and total cholesterol levels-The tail arterial blood pressure was significantly elevated with the high-fructose diet. However, rats given gravinol showed a lower blood pressure as compared with fructose-fed control rats. In addition, the triglyceride (TG) levels in serum and lipoprotein fraction were dose-dependently reduced in rats fed gravinol. The decreases of hepatic TG and total cholesterol by gravinol were responsible for the down-regulation of hepatic sterol regulatory element binding protein (SREBP)-1. However, gravinol did not affect the protein levels of hepatic peroxisome proliferator-activated receptor-alpha and SREBP-2. Moreover, gravinol administration in the fructose-fed rats markedly reduced the glycosylated protein and thiobarbituric acid-reactive substance levels in the serum and hepatic mitochondria, and it inhibited the increase of the cyclooxygenase-2 protein level as a result of the down-regulation of nuclear factor kappa B (NF-kappa B). Furthermore, the decrease of anti-apoptotic bcl-2 protein levels and the increase of pro-apoptotic bax protein levels by the high-fructose diet were reversed by gravinol. These findings suggest that fructose-induced metabolic syndrome is attenuated by gravinol administration, which is associated with the reduction of serum lipids and protection against the proinflammatory state induced by oxidative stress.
C1 [Yokozawa, Takak; Kim, Hyun Ju] Toyama Univ, Inst Nat Med, Toyama 9300194, Japan.
   [Cho, Eun Ju] Pusan Natl Univ, Dept Food Sci & Nutr, Pusan 609735, South Korea.
C3 University of Toyama; Pusan National University
RP Yokozawa, T (corresponding author), Toyama Univ, Inst Nat Med, 2630 Sugitani, Toyama 9300194, Japan.
EM yokozawa@inm.u-toyama.ac.jp
RI Kim, Kyung/I-5501-2015
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NR 45
TC 43
Z9 49
U1 0
U2 11
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0021-8561
J9 J AGR FOOD CHEM
JI J. Agric. Food Chem.
PD JUL 9
PY 2008
VL 56
IS 13
BP 5026
EP 5032
DI 10.1021/jf800213f
PG 7
WC Agriculture, Multidisciplinary; Chemistry, Applied; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture; Chemistry; Food Science & Technology
GA 321VU
UT WOS:000257335400021
PM 18540612
DA 2025-06-11
ER

PT J
AU Ozcan, L
   Tabas, I
AF Ozcan, L.
   Tabas, I.
TI Calcium signalling and ER stress in insulin resistance and
   atherosclerosis
SO JOURNAL OF INTERNAL MEDICINE
LA English
DT Article
DE atherosclerosis; calcium; diabetes mellitus; insulin resistance;
   metabolic syndrome
ID ENDOPLASMIC-RETICULUM STRESS; UNFOLDED PROTEIN RESPONSE; HEPATIC
   GLUCOSE-PRODUCTION; OXIDATIVE STRESS; SKELETAL-MUSCLE; LINKS OBESITY;
   KINASE-II; APOPTOSIS; HOMEOSTASIS; MACROPHAGES
AB The burden of type 2 diabetes and its major complication cardiovascular disease is rapidly increasing worldwide. Understanding the underlying pathogenic mechanisms of these diseases is crucial to develop novel therapeutics. Recent work using genetic and biochemical methods in mouse models and human samples have identified disturbed calcium signalling and endoplasmic reticulum stress as emerging factors involved in the pathogenesis of many metabolic diseases. In this review, we will highlight the specific roles of calcium signalling and endoplasmic reticulum stress response in the development of insulin resistance and atherosclerosis.
C1 [Ozcan, L.; Tabas, I.] Columbia Univ, Dept Med, New York, NY 10032 USA.
   [Tabas, I.] Columbia Univ, Dept Physiol & Cellular Biophys, New York, NY USA.
   [Tabas, I.] Columbia Univ, Dept Pathol & Cell Biol, New York, NY USA.
C3 Columbia University; Columbia University; Columbia University
RP Ozcan, L (corresponding author), Columbia Univ, Dept Med, New York, NY 10032 USA.
EM lo2192@columbia.edu
OI Tabas, Ira/0000-0003-3429-1515
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TC 54
Z9 59
U1 0
U2 12
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0954-6820
EI 1365-2796
J9 J INTERN MED
JI J. Intern. Med.
PD NOV
PY 2016
VL 280
IS 5
BP 457
EP 464
DI 10.1111/joim.12562
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA EA8VL
UT WOS:000386917400004
PM 27739133
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Selejan, SR
   Linz, D
   Mauz, M
   Hohl, M
   Huynh, AKD
   Speer, T
   Wintrich, J
   Kazakov, A
   Werner, C
   Mahfoud, F
   Böhm, M
AF Selejan, Simina-Ramona
   Linz, Dominik
   Mauz, Muriel
   Hohl, Mathias
   Huynh, Anh Khoa Dennis
   Speer, Thimoteus
   Wintrich, Jan
   Kazakov, Andrey
   Werner, Christian
   Mahfoud, Felix
   Boehm, Michael
TI Renal denervation reduces atrial remodeling in hypertensive rats with
   metabolic syndrome
SO BASIC RESEARCH IN CARDIOLOGY
LA English
DT Article
DE Renal denervation; Metabolic syndrome; Atrial remodeling; RAGE; CML;
   HMGB1
ID GLYCATION END-PRODUCTS; CATHETER ABLATION; OXIDATIVE STRESS; SOLUBLE
   RAGE; FIBRILLATION; RECEPTOR; HEART; FIBROSIS; MECHANISMS; KIDNEY
AB Atrial fibrillation (AF) is highly prevalent in hypertensive patients with metabolic syndrome and is related to inflammation and activation of the sympathoadrenergic system. The multi-ligand Receptor-for-Advanced-Glycation-End-products (RAGE) activates inflammation-associated tissue remodeling and is regulated by the sympathetic nervous system. Its counterpart, soluble RAGE (sRAGE), serves as anti-inflammatory decoy receptor with protective properties. We investigated the effect of sympathetic modulation by renal denervation (RDN) on atrial remodeling, RAGE/sRAGE and RAGE ligands in metabolic syndrome. RDN was performed in spontaneously hypertensive obese rats (SHRob) with metabolic syndrome compared with lean spontaneously hypertensive rats (SHR) and with normotensive non-obese control rats. Blood pressure and heart rate were measured by telemetry. The animals were killed 12 weeks after RDN. Left atrial (LA) and right atrial (RA) remodeling was assessed by histological analysis and collagen types. Sympathetic innervation was measured by tyrosine hydroxylase staining of atrial nerve fibers, RAGE/sRAGE, RAGE ligands, cytokine expressions and inflammatory infiltrates were analyzed by Western blot and immunofluorescence staining. LA sympathetic nerve fiber density was higher in SHRob (+44%) versus controls and reduced after RDN (-64% versus SHRob). RAGE was increased (+718%) and sRAGE decreased (- 62%) in SHRob as compared with controls. RDN reduced RAGE expression (- 61% versus SHRob), significantly increased sRAGE levels (+162%) and induced a significant decrease in RAGE ligand levels in SHRob (- 57% CML and - 51% HMGB1) with reduced pro-inflammatory NFkB activation (- 96%), IL-6 production (- 55%) and reduced inflammatory infiltrates. This led to a reduction in atrial fibrosis (- 33%), collagen type I content (- 72%), accompanied by reduced LA myocyte hypertrophy (- 21%). Transfection experiments on H9C2 cardiomyoblasts demonstrated that RAGE is directly involved in fibrosis formation by influencing cellular production of collagen type I. In conclusion, suppression of renal sympathetic nerve activity by RDN prevents atrial remodeling in metabolic syndrome by reducing atrial sympathetic innervation and by modulating RAGE/sRAGE balance and reducing pro-inflammatory and pro-fibrotic RAGE ligands, which provides a potential therapeutic mechanism to reduce the development of AF.
C1 [Selejan, Simina-Ramona; Linz, Dominik; Mauz, Muriel; Hohl, Mathias; Huynh, Anh Khoa Dennis; Wintrich, Jan; Kazakov, Andrey; Werner, Christian; Mahfoud, Felix; Boehm, Michael] Univ Saarland, Klin Innere Med Kardiol Angiol & Internist Intens, Univ Klinikum Saarlandes, Kirrbergerstr 100,Geb 41-1 IMED, D-66421 Homburg, Germany.
   [Selejan, Simina-Ramona; Linz, Dominik; Mauz, Muriel; Hohl, Mathias; Huynh, Anh Khoa Dennis; Speer, Thimoteus; Wintrich, Jan; Kazakov, Andrey; Werner, Christian; Mahfoud, Felix; Boehm, Michael] Univ Saarland, Med Fak, Kirrbergerstr 100,Geb 41-1 IMED, D-66421 Homburg, Germany.
   [Speer, Thimoteus] Univ Saarland, Klin Innere Med Nephrol & Hochdruckkrankheiten 4, Univ Klinikum Saarlandes, Homburg, Germany.
C3 Universitatsklinikum des Saarlandes; Saarland University; Saarland
   University; Universitatsklinikum des Saarlandes; Saarland University
RP Selejan, SR (corresponding author), Univ Saarland, Klin Innere Med Kardiol Angiol & Internist Intens, Univ Klinikum Saarlandes, Kirrbergerstr 100,Geb 41-1 IMED, D-66421 Homburg, Germany.; Selejan, SR (corresponding author), Univ Saarland, Med Fak, Kirrbergerstr 100,Geb 41-1 IMED, D-66421 Homburg, Germany.
EM simina.selejan@uks.eu
RI Mahfoud, Felix/D-7707-2011; Wintrich, Jan/MIK-8589-2025; Böhm,
   Michael/C-3638-2011; Linz, Dominik/J-2558-2019
OI Speer, Thimoteus/0000-0002-2491-6393; Mahfoud,
   Felix/0000-0002-4425-549X; Linz, Dominik/0000-0003-4893-0824
FU Projekt DEAL; HOMFOR; German Heart Foundation [F/03/15]; German Research
   Foundation (Deutsche Forschungsgemeinschaft) [SFB/TRR 219, 322900939,
   M02/S02, S01, M06, C08]
FX Open Access funding enabled and organized by Projekt DEAL. This work was
   supported by HOMFOR 2015/2016 to SRS, the German Heart Foundation
   (F/03/15 to SRS and DL), the German Research Foundation (Deutsche
   Forschungsgemeinschaft, SFB/TRR 219 (Project-ID 322900939) to SRS, DL,
   MH, AK, CW, TS, FM and MB (M02/S02, S01, M06, C08)).
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NR 68
TC 12
Z9 14
U1 0
U2 8
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 0300-8428
EI 1435-1803
J9 BASIC RES CARDIOL
JI Basic Res. Cardiol.
PD DEC
PY 2022
VL 117
IS 1
AR 36
DI 10.1007/s00395-022-00943-6
PG 19
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 2X7ZE
UT WOS:000825417500002
PM 35834066
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Çayir, A
   Turan, MI
   Gurbuz, F
   Kurt, N
   Yildirim, A
AF Cayir, Atilla
   Turan, Mehmet Ibrahim
   Gurbuz, Fatih
   Kurt, Nezahat
   Yildirim, Abdulkadir
TI The effect of lifestyle change and metformin therapy on serum
   arylesterase and paraoxonase activity in obese children
SO JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
LA English
DT Article
DE arylesterase; child; obesity; oxidative stress; paraoxonase
ID BODY-MASS INDEX; OXIDATIVE STRESS; CARDIOVASCULAR-DISEASE;
   DENSITY-LIPOPROTEIN; GLUCOSE-METABOLISM; INSULIN-RESISTANCE; CHILDHOOD
   OBESITY; INFLAMMATION; ADOLESCENTS; OVERWEIGHT
AB Aim: Obesity is known to be associated with many diseases in the long and short terms. Elevated oxidative stress contributes to the development of such obesity-related diseases as dyslipidemia, diabetes mellitus and hypertension. Levels of the endogenous antioxidants paraoxonase and arylesterase have been shown to decrease in such diseases. The purpose of this study was to investigate whether or not changes in lifestyle and metformin therapy would affect serum paraoxonase and arylesterase levels.
   Materials and methods: The study was performed with 25 overweight, 26 obese and 25 morbidly obese patients aged 6-15 years as well as 27 healthy children. Serum paraoxonase (PON1) and arylesterase (ARE) activity levels and total cholesterol, triglyceride, low-density protein, highdensity protein, very low-density protein, glucose, aspartate amino transferase and alanine amino transferase levels were measured. Enrolled patients were assessed at initial presentation and again at 6 months. No procedure was performed in the control group, while the overweight, obese and morbidly obese groups were recommended diet and exercise and given metformin therapy (insulinresistant subjects only).
   Results: Serum PON1 activity levels in patients with metabolic syndrome were significantly lower than those in individuals without metabolic syndrome (p<0.05), while lipid concentrations were significantly higher (p<0.05). Metabolic syndrome patients had higher serum glucose, total cholesterol, low-density protein, very low-density protein and triglyceride values compared to those of the control group but significantly lower high-density protein values (p<0.05). No difference was determined between the groups in terms of PON1 and ARE levels following diet and exercise and metformin therapy.
   Conclusion: Measurement of PON1 and ARE enzyme levels may be useful in monitoring the effectiveness of treatment aimed at reducing oxidative stress in obese children.
C1 [Cayir, Atilla] Reg Training & Res Hosp, Dept Pediat Endocrinol, Erzurum, Turkey.
   [Turan, Mehmet Ibrahim] Reg Training & Res Hosp, Dept Pediat, Diyarbakir, Turkey.
   [Gurbuz, Fatih] Cukurova Univ, Dept Pediat Endocrinol, Fac Med, Adana, Turkey.
   [Kurt, Nezahat; Yildirim, Abdulkadir] Ataturk Univ, Fac Med, Dept Biochem, Erzurum, Turkey.
C3 Erzurum Bolge Training & Research Hospital; Diyarbakir Training &
   Research Hospital; Cukurova University; Ataturk University
RP Çayir, A (corresponding author), Reg Training & Res Hosp, Dept Pediat Endocrinol, Erzurum, Turkey.
EM dratillacayir@gmail.com
RI Kurt, Nezahat/AAH-7473-2020; TURAN, MEHMET/AAG-5316-2020; gurbuz,
   fatih/J-2700-2013
OI gurbuz, fatih/0000-0003-2160-9838
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NR 45
TC 7
Z9 7
U1 0
U2 13
PU WALTER DE GRUYTER GMBH
PI BERLIN
PA GENTHINER STRASSE 13, D-10785 BERLIN, GERMANY
SN 0334-018X
EI 2191-0251
J9 J PEDIATR ENDOCR MET
JI J. Pediatr. Endocrinol. Metab.
PD MAY
PY 2015
VL 28
IS 5-6
BP 551
EP 556
DI 10.1515/jpem-2013-0486
PG 6
WC Endocrinology & Metabolism; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Pediatrics
GA CH1PE
UT WOS:000353793000010
PM 25252747
DA 2025-06-11
ER

PT J
AU Madani, Z
   Sener, A
   Malaisse, WJ
   Dalila, AY
AF Madani, Zohra
   Sener, Abdullah
   Malaisse, Willy J.
   Dalila, Ait Yahia
TI Sardine protein diet increases plasma glucagon-like peptide-1 levels and
   prevents tissue oxidative stress in rats fed a high-fructose diet
SO MOLECULAR MEDICINE REPORTS
LA English
DT Article
DE metabolic syndrome; fructose; rat; sardine protein; tissues; lipid
   peroxidation; antioxidant enzymes
ID INSULIN-RESISTANT MEN; METABOLIC SYNDROME; COD PROTEIN; SKELETAL-MUSCLE;
   SOY PROTEIN; CARBONYL CONTENT; FATTY-ACIDS; TYPE-2; FISH; SENSITIVITY
AB The current study investigated whether sardine protein mitigates the adverse effects of fructose on plasma glucagon-like peptide-1 (GLP-1) and oxidative stress in rats. Rats were fed casein (C) or sardine protein (S) with or without high-fructose (HF) for 2 months. Plasma glucose, insulin, GLP-1, lipid and protein oxidation and antioxidant enzymes were assayed. HF rats developed obesity, hyperglycemia, hyperinsulinemia, insulin resistance and oxidative stress despite reduced energy and food intakes. High plasma creatinine and uric acid levels, in addition to albuminuria were observed in the HF groups. The S-HF diet reduced plasma glucose, insulin, creatinine, uric acid and homeostasis model assessment-insulin resistance index levels, however increased GLP-1 levels compared with the C-HF diet. Hydroperoxides were reduced in the liver, kidney, heart and muscle of S-HF fed rats compared with C-HF fed rats. A reduction in liver, kidney and heart carbonyls was observed in S-HF fed rats compared with C-HF fed rats. Reduced levels of nitric oxide (NO) were detected in the liver, kidney and heart of the S-HF fed rats compared with C-HF fed rats. The S diet compared with the C diet reduced levels of liver hydroperoxides, heart carbonyls and kidney NO. The S-HF diet compared with the C-HF diet increased the levels of liver and kidney superoxide dismutase, liver and muscle catalase, liver, heart and muscle glutathione peroxidase and liver ascorbic acid. The S diet prevented and reversed insulin resistance and oxidative stress, and may have benefits in patients with metabolic syndrome.
C1 [Madani, Zohra; Dalila, Ait Yahia] Univ Oran, Fac Nat & Life Sci, Dept Biol, Oran 31000, Algeria.
   [Sener, Abdullah] Free Univ Brussels, Fac Med, Lab Physiol & Pharmacol, B-1070 Brussels, Belgium.
   [Malaisse, Willy J.] Free Univ Brussels, Dept Biochem, B-1070 Brussels, Belgium.
C3 Universite d'Oran; Universite Libre de Bruxelles; Universite Libre de
   Bruxelles
RP Dalila, AY (corresponding author), Univ Oran, Fac Nat & Life Sci, Dept Biol, BP 1524 El MNaouer, Es Senia 31000, Oran, Algeria.
EM aityahiad@yahoo.fr
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NR 59
TC 8
Z9 8
U1 0
U2 11
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1791-2997
EI 1791-3004
J9 MOL MED REP
JI Mol. Med. Rep.
PD NOV
PY 2015
VL 12
IS 5
BP 7017
EP 7026
DI 10.3892/mmr.2015.4324
PN A
PG 10
WC Oncology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Research & Experimental Medicine
GA CW3JP
UT WOS:000364888900084
PM 26398482
OA Bronze
DA 2025-06-11
ER

PT J
AU Campanher, G
   Andrade, N
   Lopes, J
   Silva, C
   Pena, MJ
   Rodrigues, I
   Martel, F
AF Campanher, Gabriela
   Andrade, Nelson
   Lopes, Joanne
   Silva, Claudia
   Pena, Maria Joao
   Rodrigues, Ilda
   Martel, Fatima
TI The Counteracting Effect of Chrysin on Dietary Fructose-Induced
   Metabolic-Associated Fatty Liver Disease (MAFLD) in Rats with a Focus on
   Glucose and Lipid Metabolism
SO MOLECULES
LA English
DT Article
DE fructose; chrysin; liver; adipose tissue; tissue injury
ID OXIDATIVE STRESS; GLYCOGEN-SYNTHASE; MECHANISM
AB The prevalence of metabolic syndrome has been exponentially increasing in recent decades. Thus, there is an increasing need for affordable and natural interventions for this disorder. We explored the effect of chrysin, a dietary polyphenol, on hepatic lipid and glycogen accumulation, metabolic dysfunction-associated fatty liver disease (MAFLD) activity score and oxidative stress and on hepatic and adipose tissue metabolism in rats presenting metabolic syndrome-associated conditions. Rats fed a chow diet were separated into four groups: Control (tap water), Fructose (tap water with 10% fructose), Chrysin (tap water+ chrysin (100 mg/kg body weight/d)), and Fructose + Chrysin (tap water with 10% fructose + chrysin (100 mg/kg body weight/d, daily)) (for 18 weeks). When associated with the chow diet, chrysin reduced hepatic lipid and glycogen storage, increased the hepatic antioxidant potential of glutathione and reduced de novo lipogenesis in the adipose tissue. When associated with the high fructose-diet, chrysin attenuated the increase in lipid and glycogen hepatic storage, improved the MAFLD activity score, decreased hepatic lipid peroxidation, increased the antioxidant potential of glutathione, and improved lipid and glucose metabolic markers in the liver and adipose tissue. In conclusion, our results suggest that chrysin is a beneficial addition to a daily diet for improvement of hepatic metabolic health, particularly for individuals suffering from metabolic syndrome.
C1 [Campanher, Gabriela; Andrade, Nelson; Silva, Claudia; Pena, Maria Joao; Rodrigues, Ilda; Martel, Fatima] Univ Porto, Fac Med Porto, Dept Biomed, Unit Biochem, P-4200319 Porto, Portugal.
   [Campanher, Gabriela] Univ Orebro, Sch Med Sci, Campus USO, S-70182 Orebro, Sweden.
   [Andrade, Nelson; Silva, Claudia] Univ Porto, Fac Pharm, Dept Chem Sci, REQUIMTE,LAQV, RJ Viterbo Ferreira 228, P-4050313 Porto, Portugal.
   [Lopes, Joanne] Univ Porto, Fac Med Porto, Dept Pathol, P-4200319 Porto, Portugal.
   [Rodrigues, Ilda; Martel, Fatima] Univ Porto, Inst Invest & Inovacao Saude I3S, P-4200135 Porto, Portugal.
C3 Universidade do Porto; Orebro University; Universidade do Porto;
   Universidade do Porto; Universidade do Porto; i3S - Instituto de
   Investigacao e Inovacao em Saude, Universidade do Porto
RP Martel, F (corresponding author), Univ Porto, Fac Med Porto, Dept Biomed, Unit Biochem, P-4200319 Porto, Portugal.; Martel, F (corresponding author), Univ Porto, Inst Invest & Inovacao Saude I3S, P-4200135 Porto, Portugal.
EM gabi.campanher@hotmail.com; nandrade@med.up.pt; joannedlopes@msn.com;
   claudiasilva@med.up.pt; mariajoao0502@gmail.com; irodrigues@med.up.pt;
   fmartel@med.up.pt
RI Martel, Felix/JFJ-0587-2023; Andrade, Nelson/AAK-3763-2021
OI Martel, Fatima/0000-0002-0525-3416; Silva, Claudia/0000-0003-2937-974X;
   Andrade, Nelson/0000-0003-2600-8599; Lopes, Joanne/0000-0002-2339-2823
FU Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior-Brazilian
   Federal Agency; Evaluation of Graduate Education within the Ministry of
   Education of Brazil [PN: 10103/13-9]; European Regional Development Fund
   - Programa Operacional Competitividade e Internacionalizacao-COMPETE2020
   [POCI-01-0145-ERDF-007746]
FX This work was funded by the Coordenacao de Aperfeicoamento de Pessoal de
   Nivel Superior-Brazilian Federal Agency for Support and Evaluation of
   Graduate Education within the Ministry of Education of Brazil-PN:
   10103/13-9. It was also supported by European Regional Development Fund
   through the operation POCI-01-0145-ERDF-007746, funded by the Programa
   Operacional Competitividade e Internacionalizacao-COMPETE2020.
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NR 59
TC 0
Z9 0
U1 7
U2 7
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1420-3049
J9 MOLECULES
JI Molecules
PD JAN
PY 2025
VL 30
IS 2
AR 380
DI 10.3390/molecules30020380
PG 19
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA T3X4E
UT WOS:001404374500001
PM 39860248
OA gold
DA 2025-06-11
ER

PT J
AU Kato, J
   Koda, M
   Kishina, M
   Tokunaga, S
   Matono, T
   Sugihara, T
   Ueki, M
   Murawaki, Y
AF Kato, Jun
   Koda, Masahiko
   Kishina, Manabu
   Tokunaga, Shiho
   Matono, Tomomitsu
   Sugihara, Takaaki
   Ueki, Masaru
   Murawaki, Yoshikazu
TI Therapeutic effects of angiotensin II type 1 receptor blocker,
   irbesartan, on non-alcoholic steatohepatitis using FLS-ob/ob male mice
SO INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
LA English
DT Article
DE non-alcoholic steatohepatitis; angiotensin II type 1 receptor blocker;
   irbesartan; oxidative stress; liver steatosis; liver fibrosis; fatty
   liver Shionogi-ob/ob mice
ID BILE-DUCT LIGATION; FATTY LIVER; INSULIN-RESISTANCE; OXIDATIVE STRESS;
   ADIPOSE-TISSUE; METABOLIC SYNDROME; PPAR-ALPHA; RATS; FIBROSIS;
   TELMISARTAN
AB Non-alcoholic steatohepatitis (NASH) is the hepatic manifestation of a metabolic syndrome characterized by accumulation of hepatic fat, inflammation and varying degrees of fibrosis. Angiotensin (AT)-II has been reported to play a role in the establishment of NASH. This study examined the effects of an AT-II receptor blocker, irbesartan,on NASH using fatty liver Shionogi (FLS)-ob/ob male mice as the closest animal model of human metabolic syndrome-related NASH. Irbesartan (30 mg/kg/day) was orally administered to FLS-ob/ob mice for 12 weeks (irbesartan group). The effects of irbesartan on steatohepatitis were examined using factors including steatosis, fibrosis, inflammation and oxidative stress. The areas of hepatic fibrosis and hepatic hydroxyproline content were significantly lower in the irbesartan group compared to controls. The areas of a-smooth muscle actin-positivity and F4/80-positive cells were significantly decreased in the irbesartan group. The percentage of 8-hydroxy-2-deoxyguanosine (8-OHdG)-positive cells and 8-OHdG DNA content were significantly decreased in the irbesartan group compared to controls. Levels of RNA expression for procollagen 1, transforming growth factor beta 1, tumor necrosis factor-alpha, sterol regulatory element-binding protein 1c and fatty acid synthase were significantly lower in the irbesartan group compared to controls. In contrast, the gene expression of peroxisome proliferator activated receptor-alpha was significantly higher in the irbesartan group compared to controls. Irbesartan administration improved hepatic steatosis and attenuated the progression of hepatic fibrosis by inhibiting the activation of hepatic stellate cells and Kupffer cells and reducing oxidative stress.
C1 [Kato, Jun; Koda, Masahiko; Kishina, Manabu; Tokunaga, Shiho; Matono, Tomomitsu; Sugihara, Takaaki; Ueki, Masaru; Murawaki, Yoshikazu] Tottori Univ, Div Med & Clin Sci, Dept Multidisciplinary Internal Med, Fac Med, Yonago, Tottori 6838504, Japan.
C3 Tottori University
RP Koda, M (corresponding author), Tottori Univ, Div Med & Clin Sci, Dept Multidisciplinary Internal Med, Fac Med, 36-1 Nishicho, Yonago, Tottori 6838504, Japan.
EM masakoda@med.tottori-u.ac.jp
RI Kato, Junya/O-6144-2015
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NR 34
TC 33
Z9 39
U1 0
U2 14
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1107-3756
J9 INT J MOL MED
JI Int. J. Mol. Med.
PD JUL
PY 2012
VL 30
IS 1
BP 107
EP 113
DI 10.3892/ijmm.2012.958
PG 7
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 949MF
UT WOS:000304579600016
PM 22469867
OA Bronze
DA 2025-06-11
ER

PT J
AU Silva, LMCE
   de Melo, MLP
   Reis, FVF
   Monteiro, MC
   dos Santos, SM
   Gomes, BAQ
   da Silva, LHM
AF Costa e Silva, Livia Martins
   Pereira de Melo, Maria Luisa
   Faro Reis, Fernando Vinicius
   Monteiro, Marta Chagas
   dos Santos, Savio Monteiro
   Quadros Gomes, Bruno Alexandre
   Meller da Silva, Luiza Helena
TI Comparison of the Effects of Brazil Nut Oil and Soybean Oil on the
   Cardiometabolic Parameters of Patients with Metabolic Syndrome: A
   Randomized Trial
SO NUTRIENTS
LA English
DT Article
DE metabolic syndrome; cardiovascular diseases; Brazil nuts; plant oils;
   Bertholletia
ID LOW-DENSITY-LIPOPROTEIN; FATTY-ACID-COMPOSITION; ANTIOXIDANT CAPACITY;
   DIETARY SUPPLEMENTATION; MONOUNSATURATED FAT; LIPID-PEROXIDATION;
   OXIDATIVE STRESS; SATURATED-FAT; PLASMA-LIPIDS; COCONUT OIL
AB Recent evidence suggests that replacing saturated fat with unsaturated fat is beneficial for cardiovascular health. This study compared the effects of Brazil nut oil (BNO) and soybean oil (SO) supplementation for 30 days on anthropometric, blood pressure, biochemical, and oxidative parameters in patients with metabolic syndrome (MS). Thirty-one patients with MS were randomly allocated to receive 30 sachets with 10 mL each of either BNO (n = 15) or SO (n = 16) for daily supplementation. Variables were measured at the beginning of the study and after 30 days of intervention. No change in anthropometric and blood pressure variables were observed (p > 0.05). Total (p = 0.0253) and low-density lipoprotein (p = 0.0437) cholesterol increased in the SO group. High-density lipoprotein cholesterol decreased (p = 0.0087) and triglycerides increased (p = 0.0045) in the BNO group. Malondialdehyde levels decreased in the BNO group (p = 0.0296) and total antioxidant capacity improved in the SO group (p = 0.0110). Although the addition of oils without lifestyle interventions did not affect anthropometric findings or blood pressure and promoted undesirable results in the lipid profile in both groups, daily supplementation of BNO for 30 days decreased lipid peroxidation, contributing to oxidative stress reduction.
C1 [Costa e Silva, Livia Martins; Meller da Silva, Luiza Helena] Fed Univ Para, LAMEFI Lab Phys Measures, Postgrad Program Food Sci & Technol, BR-66075900 Belem, Para, Brazil.
   [Pereira de Melo, Maria Luisa] Univ Estadual Ceara, Nutr & Hlth, BR-60714903 Fortaleza, Ceara, Brazil.
   [Faro Reis, Fernando Vinicius] Fed Univ Para, Inst Hlth Sci, BR-66075900 Belem, Para, Brazil.
   [Monteiro, Marta Chagas; dos Santos, Savio Monteiro] Fed Univ Para, Postgrad Program Pharmaceut Sci, BR-66075900 Belem, Para, Brazil.
   [Quadros Gomes, Bruno Alexandre] Fed Univ Para, Neurosci & Cellular Biol Postgrad Program, Inst Biol Sci, BR-66075900 Belem, Para, Brazil.
C3 Universidade Federal do Para; Universidade Estadual do Ceara;
   Universidade Federal do Para; Universidade Federal do Para; Universidade
   Federal do Para
RP da Silva, LHM (corresponding author), Fed Univ Para, LAMEFI Lab Phys Measures, Postgrad Program Food Sci & Technol, BR-66075900 Belem, Para, Brazil.
EM liviacostaesilva@hotmail.com; luisa.melo@uece.br; ffaro@ufpa.br;
   martachagas@ufpa.br; saviomontsan@gmail.com; bhrunoquadros@yahoo.com.br;
   lhmeller@ufpa.br
RI da SIlva, Luiza/B-8358-2017; Monteiro, Marta/F-6575-2010
OI Monteiro, Marta/0000-0002-3328-5650; Melo, Maria
   Luisa/0000-0002-3606-2217; Costa e Silva, Livia/0000-0003-0304-9638
FU Coordination for the Improvement of Higher Education Personnel (CAPES)
   Foundation
FX This work was supported by the Coordination for the Improvement of
   Higher Education Personnel (CAPES) Foundation [$300,000].
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NR 74
TC 20
Z9 20
U1 0
U2 9
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JAN
PY 2020
VL 12
IS 1
AR 46
DI 10.3390/nu12010046
PG 14
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA KQ3KN
UT WOS:000516825500046
PM 31877968
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Morovati, A
   Gargari, BP
   Sarbakhsh, P
   Azari, H
   Lotfi-Dizaji, L
AF Morovati, Ashti
   Gargari, Bahram Pourghassem
   Sarbakhsh, Parvin
   Azari, Hushyar
   Lotfi-Dizaji, Lida
TI The effect of cumin supplementation on metabolic profiles in patients
   with metabolic syndrome: A randomized, triple blind, placebo-controlled
   clinical trial
SO PHYTOTHERAPY RESEARCH
LA English
DT Article
DE cumin supplementation; metabolic profiles; metabolic syndrome
ID CYMINUM ESSENTIAL OIL; OXIDATIVE STRESS; LIPID-PEROXIDATION; IN-VITRO;
   ANTIOXIDANT; L.; INHIBITION; PREVALENCE
AB Metabolic syndrome (MetS) is a cluster of interconnected serious disorders, which is a major health problem whose prevalence is increasing. Oxidative stress and inflammation contribute to the disease pathogenesis and its complications. The present study aimed to investigate the effect of Cuminum cyminum L. (which has antioxidant and anti-inflammatory properties) essential oil (CuEO) supplementation on inflammatory and antioxidant status in patients with MetS. In this clinical trial, 56 patients with MetS aged 18-60years received either 75-mg CuEO or placebo soft gel, thrice daily, for 8weeks. Data on anthropometric parameters, food consumption, tumor necrosis factor alpha, high-sensitivity C-reactive protein, superoxide dismutase (SOD), glutathione peroxidase, catalase, total antioxidant capacity (TAC), and malondialdehyde (MDA) were assessed at the beginning and at the end of the study. Compared with the placebo group, CuEO increased SOD (149.17; 95% CI, [67.93, 230.42]), TAC (0.24; 95% CI, [0.09, 0.38]) and decreased MDA (-0.36; 95% CI, [-0.66, 0.06]), (p<0.01). In within-group analysis, CuEO led to 13.3% decrease in MDA and 6.7% increase in TAC levels (p<0.04). The results indicated that CuEO supplementation can improve some antioxidative indices, as SOD and TAC, while decreasing MDA in patients with MetS.
C1 [Morovati, Ashti; Lotfi-Dizaji, Lida] Tabriz Univ Med Sci, Fac Nutr & Food Sci, Dept Biochem & Diet Therapy, Student Res Comm, Tabriz, Iran.
   [Gargari, Bahram Pourghassem] Tabriz Univ Med Sci, Fac Nutr & Food Sci, Dept Biochem & Diet Therapy, Nutr Res Ctr, Tabriz, Iran.
   [Sarbakhsh, Parvin] Tabriz Univ Med Sci, Fac Hlth, Dept Epidemiol & Biostat, Tabriz, Iran.
   [Azari, Hushyar] Urmia Univ Med Sci, Fac Med, Orumiyeh, Iran.
C3 Tabriz University of Medical Science; Tabriz University of Medical
   Science; Tabriz University of Medical Science; Urmia University of
   Medical Sciences
RP Gargari, BP (corresponding author), Tabriz Univ Med Sci, Fac Nutr & Food Sci, Dept Biochem & Diet Therapy, Nutr Res Ctr, Tabriz, Iran.
EM bahrampg@yahoo.com
RI Sarbakhsh, Parvin/D-8567-2017; Pourghassem Gargari, Bahram/D-3556-2017
OI Sarbakhsh, Parvin/0000-0002-4213-5152; Pourghassem Gargari,
   Bahram/0000-0001-7667-099X
FU Vice-chancellor for Research and Student Research Committee of Tabriz
   University of Medical Sciences [5/D/10479, 2017/5/8]
FX Vice-chancellor for Research and Student Research Committee of Tabriz
   University of Medical Sciences, Grant/Award Number: 5/D/10479, 2017/5/8.
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NR 36
TC 5
Z9 6
U1 0
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0951-418X
EI 1099-1573
J9 PHYTOTHER RES
JI Phytother. Res.
PD APR
PY 2019
VL 33
IS 4
BP 1182
EP 1190
DI 10.1002/ptr.6313
PG 9
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA HW7XM
UT WOS:000466903300034
PM 30762267
DA 2025-06-11
ER

PT J
AU Davis, L
   Stonehouse, W
   Loots, DT
   Mukuddem-Petersen, J
   van der Westhuizen, FH
   Hanekom, SM
   Jerling, JC
AF Davis, Lisa
   Stonehouse, Welma
   Loots, Du Toit
   Mukuddem-Petersen, Janine
   van der Westhuizen, Francois H.
   Hanekom, Susanna M.
   Jerling, Johann C.
TI The effects of high walnut and cashew nut diets on the antioxidant
   status of subjects with metabolic syndrome
SO EUROPEAN JOURNAL OF NUTRITION
LA English
DT Article
DE cashew nuts; walnuts; antioxidant status; polyphenols; redox status;
   metabolic syndrome
ID OXIDATIVE STRESS; PLASMA; CHOLESTEROL; CONSUMPTION; FLAVONOIDS;
   RESISTANCE; CAPACITY
AB Background Nut consumption is associated with a protective effect against coronary heart disease, partly due to its high antioxidant content. It is hypothesized that the inclusion of nuts in the diet will improve the antioxidant status of subjects with metabolic syndrome who may be vulnerable to impaired antioxidant status. Aim The effects of high cashew nut and high walnut diets on the antioxidant status of subjects with metabolic syndrome are investigated. Methodology Sixty-four volunteers (29 male and 35 female, 45 +/- 10y) with metabolic syndrome (diagnosed by using the ATP III criteria) received a prudent control diet, prepared in the metabolic kitchen of the North-West University, Potchefstroom campus (NWU-PC) for a period of 3 weeks (run-in). The participants were grouped according to gender and age and randomized into three groups, receiving either the walnut, cashew nut or the control diets for 8 weeks, while maintaining a stable body weight. Nuts provided 20% of daily energy intake. Fasting blood samples were taken after the run-in period (baseline) and at the end of the intervention period and analyzed for various antioxidant capacity markers. Results The oxygen radical absorbance capacity (ORAC) of the walnut and cashew nut diets were significantly higher than the control diet. Despite this, the walnut and cashew nut diets had no significant effects on serum ORAC, reduced (GSH), oxidized (GSSG) glutathione, GSH:GSSG or diacron reactive metabolites (dRom) (total oxidant status) levels compared to the control group. However, all three groups showed significant improvements in antioxidant status from baseline to end (GSSG and dRom levels decreased; GSG:GSSG ratio and ORAC levels increased). This may be due to a general increased antioxidant intake from the prudent diet compared to the habitual diets. Conclusion Although the inclusion of walnuts and cashew nuts into a prudent diet resulted in an increased antioxidant capacity (ORAC) of the nut diets, compared to the control diet, it did not improve the serum antioxidant profiles of subjects with metabolic syndrome.
C1 NW Univ, Sch Physiol Nutr & Consumer Sci, ZA-2520 Potchefstroom, South Africa.
   Massey Univ, Inst Food Nutr & Human Hlth, Auckland, New Zealand.
   NW Univ, Sch Biochem, ZA-2520 Potchefstroom, South Africa.
C3 North West University - South Africa; Massey University; North West
   University - South Africa
RP Davis, L (corresponding author), NW Univ, Sch Physiol Nutr & Consumer Sci, Private Bag X6001, ZA-2520 Potchefstroom, South Africa.
EM vgeld@puk.ac.za
RI Loots, Du Toit/U-1360-2017; Stonehouse, Welma/H-2316-2013; van der
   Westhuizen, Francois/E-6959-2011
OI Loots, Du Toit/0000-0002-0339-6237; Stonehouse,
   Welma/0000-0002-2856-4962; Hanekom, Susanna M/0000-0001-7874-7807; van
   der Westhuizen, Francois/0000-0002-7879-1776; Jerling,
   Johann/0000-0003-2600-3536
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PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1436-6207
EI 1436-6215
J9 EUR J NUTR
JI Eur. J. Nutr.
PD APR
PY 2007
VL 46
IS 3
BP 155
EP 164
DI 10.1007/s00394-007-0647-x
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 150IO
UT WOS:000245209700005
PM 17377830
DA 2025-06-11
ER

PT J
AU Bowman, MA
   Duggan, KA
   Brindle, RC
   Kline, CE
   Krafty, RT
   Thayer, JF
   Hall, MH
AF Bowman, Marissa A.
   Duggan, Katherine A.
   Brindle, Ryan C.
   Kline, Christopher E.
   Krafty, Robert T.
   Thayer, Julian F.
   Hall, Martica H.
TI Prospective associations among objectively and subjectively assessed
   sleep and the metabolic syndrome
SO SLEEP MEDICINE
LA English
DT Article
DE Sleep; Polysomnography; Pittsburgh sleep quality index; Metabolic
   syndrome; Cardiometabolic health; Glucose
ID ALL-CAUSE MORTALITY; DURATION; METAANALYSIS; INSOMNIA; QUALITY; RISK;
   POPULATION; DEPRESSION; PREDICTION; SYMPTOMS
AB Objective: Subjective sleep disturbances have been associated with greater risk for concurrent and incident metabolic syndrome (MetS). Previous studies have not examined prospective associations among polysomnography-assessed sleep and the MetS, despite knowledge that self-reported sleep is subject to reporting bias, and that subjectively and objectively assessed sleep are weakly correlated.
   Method: In the current study, objectively-assessed (polysomnography) and subjectively-assessed (Pittsburgh Sleep Quality Index, PSQI) sleep was measured in 145 adults at two timepoints, separated by 12-30 years. A continuous measure of the MetS was assessed at the second time point. Statistical analyses were adjusted for age, sex, lifetime history of major depressive disorder, follow-up time, and apnea-hypopnea index.
   Results: Polysomnography-assessed sleep duration, latency, efficiency, and slow wave sleep were not significantly prospectively associated with the MetS (ps >= 0.16). Self-reported longer sleep latency was prospectively associated with higher MetS scores in unadjusted (beta = 0.29, p = 0.002) and adjusted models (beta = 0.25, p = 0.009). Longer sleep latency was associated with higher fasting glucose levels (beta = 0.47, p < 0.001).
   Conclusion: Our study provides evidence that subjective and objective measures of sleep may differ in their ability to prospectively predict MetS. (C) 2019 Published by Elsevier B.V.
C1 [Bowman, Marissa A.] Univ Pittsburgh, Dept Psychol, Pittsburgh, PA 15260 USA.
   [Duggan, Katherine A.; Hall, Martica H.] Univ Pittsburgh, Dept Psychiat, Pittsburgh, PA USA.
   [Brindle, Ryan C.] Washington & Lee Univ, Dept Cognit & Behav Sci, Lexington, VA 24450 USA.
   [Brindle, Ryan C.] Washington & Lee Univ, Neurosci Program, Lexington, VA 24450 USA.
   [Kline, Christopher E.] Univ Pittsburgh, Dept Hlth & Phys Act, Pittsburgh, PA USA.
   [Krafty, Robert T.] Univ Pittsburgh, Dept Biostat, Pittsburgh, PA 15261 USA.
   [Thayer, Julian F.] Ohio State Univ, Dept Psychol, Columbus, OH USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE); University
   of Pittsburgh; Pennsylvania Commonwealth System of Higher Education
   (PCSHE); University of Pittsburgh; Washington & Lee University;
   Washington & Lee University; Pennsylvania Commonwealth System of Higher
   Education (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth
   System of Higher Education (PCSHE); University of Pittsburgh; University
   System of Ohio; Ohio State University
RP Hall, MH (corresponding author), 3811 OHara St,Rm E-1131, Pittsburgh, PA 15213 USA.
EM hallmh@upmc.edu
RI Thayer, Julian/AAA-1161-2020; Duggan, Katherine/ABE-4293-2020; Hall,
   Martica/D-2809-2012; Bowman, Marissa/AFV-4628-2022; Kline,
   Christopher/B-1477-2012
OI Hall, Martica/0000-0003-0642-2098; Bowman, Marissa/0000-0002-9146-7890;
   Kline, Christopher/0000-0003-1025-9430; Duggan, Katherine
   A./0000-0003-1768-3365
FU National Institutes of Health [R01 HL104607, R01 MH024652, R01 MH029618,
   R01 MH049115, R01 MH041884];  [R01 GM113243];  [K23 HL118318];  [F32
   HL137227];  [T32 HL07560];  [UL1 TR000005]
FX Supported by grants from the National Institutes of Health: Primary T2
   study was R01 HL104607 (MHH). T1 studies were R01 MH024652 and R01
   MH029618 (D. Kupfer), R01 MH049115 (E. Frank), and R01 MH041884 (M.
   Thase). Partial support for investigator effort was also provided by R01
   GM113243 (RTK, MHH), K23 HL118318 (CEK), F32 HL137227 (RCB), and T32
   HL07560 (MAB, KAD). Infrastructure support was provided by UL1 TR000005.
   The funding source had no involvement in study design, data collection,
   analysis, writing of the report, or in the decision to submit the
   article for publication.
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NR 36
TC 16
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U1 0
U2 9
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1389-9457
EI 1878-5506
J9 SLEEP MED
JI Sleep Med.
PD JUN
PY 2019
VL 58
BP 1
EP 6
DI 10.1016/j.sleep.2019.02.005
PG 6
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA IC3GC
UT WOS:000470846500001
PM 31028926
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Xiang, GL
   Guo, S
   Xing, N
   Du, QY
   Qin, J
   Gao, HM
   Zhang, Y
   Wang, SH
AF Xiang, Gelin
   Guo, Sa
   Xing, Nan
   Du, Qinyun
   Qin, Jing
   Gao, Huimin
   Zhang, Yi
   Wang, Shaohui
TI Mangiferin, a Potential Supplement to Improve Metabolic Syndrome:
   Current Status and Future Opportunities
SO AMERICAN JOURNAL OF CHINESE MEDICINE
LA English
DT Article
DE Mangiferin; Metabolic Syndrome; Network Pharmacology; Molecular Docking;
   Review
ID ENDOPLASMIC-RETICULUM STRESS; INSULIN-RESISTANCE; ADIPOSE-TISSUE;
   PROTEIN-KINASE; IN-VITRO; INFLAMMATION; MODULATION; EXPRESSION; LIVER;
   OBESITY
AB Metabolic syndrome (MetS) represents a considerable clinical and public health burden worldwide. Mangiferin (MF), a flavonoid compound present in diverse species such as mango (Mangifera indica L.), papaya (Pseudocydonia sinensis (Thouin) C. K. Schneid.), zhimu (Anemarrhena asphodeloides Bunge), and honeybush tea (Cyclopia genistoides), boasts a broad array of pharmacological effects. It holds promising uses in nutritionally and functionally targeted foods, particularly concerning MetS treatment. It is therefore pivotal to systematically investigate MF's therapeutic mechanism for MetS and its applications in food and pharmaceutical sectors. This review, with the aid of a network pharmacology approach complemented by this experimental studies, unravels possible mechanisms underlying MF's MetS treatment. Network pharmacology results suggest that MF treats MetS effectively through promoting insulin secretion, targeting obesity and inflammation, alleviating insulin resistance (IR), and mainly operating via the phosphatidylinositol 3 kinase (PI3K)/Akt, nuclear factor kappa-B (NF-kappa B), microtubule-associated protein kinase (MAPK), and oxidative stress signaling pathways while repairing damaged insulin signaling. These insights provide a comprehensive framework to understand MF's potential mechanisms in treating MetS. These, however, warrant further experimental validation. Moreover, molecular docking techniques confirmed the plausibility of the predicted outcomes. Hereafter, these findings might form the theoretical bedrock for prospective research into MF's therapeutic potential in MetS therapy.
C1 [Xiang, Gelin; Qin, Jing; Zhang, Yi; Wang, Shaohui] Sch Ethn Med, State Key Lab Southwestern, Chinese Med Resources, Chengdu, Peoples R China.
   [Guo, Sa; Xing, Nan; Du, Qinyun] Chengdu Univ Tradit Chinese Med, Sch Pharm, Chengdu 611137, Peoples R China.
   [Gao, Huimin; Wang, Shaohui] Chengdu Univ Tradit Chinese Med, Meishan Hosp, Meishan 620010, Peoples R China.
   [Zhang, Yi; Wang, Shaohui] Chengdu Univ Tradit Chinese Med, Sch Ethn Med, State Key Lab Southwestern Chinese Med Resources, 1166 Liutai Ave,Wenjiang Dist, Chengdu, Peoples R China.
   [Wang, Shaohui] Chengdu Univ Tradit Chinese Med, Meishan Hosp, 9,North Sect Mindong Ave,Dongpo Dist, Meishan 620010, Peoples R China.
C3 Chengdu University of Traditional Chinese Medicine; Chengdu University
   of Traditional Chinese Medicine; Chengdu University of Traditional
   Chinese Medicine; Chengdu University of Traditional Chinese Medicine
RP Zhang, Y; Wang, SH (corresponding author), Chengdu Univ Tradit Chinese Med, Sch Ethn Med, State Key Lab Southwestern Chinese Med Resources, 1166 Liutai Ave,Wenjiang Dist, Chengdu, Peoples R China.; Wang, SH (corresponding author), Chengdu Univ Tradit Chinese Med, Meishan Hosp, 9,North Sect Mindong Ave,Dongpo Dist, Meishan 620010, Peoples R China.
EM zhangyi@cdutcm.edu.cn; winter9091@163.com
RI Qin, Jing/U-1171-2019; Xiang, GeLin/KQU-4539-2024; Wang,
   Shaohui/HKO-6774-2023; Hui-Min, Gao/AAU-7990-2021
FU National Natural Science Foundation of China [81973573]
FX This study was supported by the National Natural Science Foundation of
   China (81973573).
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NR 130
TC 3
Z9 3
U1 8
U2 38
PU WORLD SCIENTIFIC PUBL CO PTE LTD
PI SINGAPORE
PA 5 TOH TUCK LINK, SINGAPORE 596224, SINGAPORE
SN 0192-415X
EI 1793-6853
J9 AM J CHINESE MED
JI Am. J. Chin. Med.
PY 2024
VL 52
IS 02
BP 355
EP 386
DI 10.1142/S0192415X24500150
EA MAR 2024
PG 32
WC Integrative & Complementary Medicine; Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine; General & Internal Medicine
GA NV2R3
UT WOS:001191227100001
PM 38533569
DA 2025-06-11
ER

PT J
AU Bode, D
   Wen, Y
   Hegemann, N
   Primessnig, U
   Parwani, A
   Boldt, LH
   Pieske, BM
   Heinzel, FR
   Hohendanner, F
AF Bode, David
   Wen, Yan
   Hegemann, Niklas
   Primessnig, Uwe
   Parwani, Abdul
   Boldt, Leif-Hendrik
   M. Pieske, Burkert
   R. Heinzel, Frank
   Hohendanner, Felix
TI Oxidative Stress and Inflammatory Modulation of Ca<SUP>2+</SUP> Handling
   in Metabolic HFpEF-Related Left Atrial Cardiomyopathy
SO ANTIOXIDANTS
LA English
DT Article
DE inflammation; reactive oxygen species; atrial cardiomyopathy; heart
   failure with preserved ejection fraction (HFpEF); metabolic syndrome;
   excitation-contraction coupling; calcium; left atrial cardiomyocytes
ID PRESERVED EJECTION FRACTION; ADVANCED HEART-FAILURE; NF-KAPPA-B;
   SARCOPLASMIC-RETICULUM; TNF-ALPHA; CALCIUM; PHOSPHORYLATION;
   DYSFUNCTION; MYOCYTES; THERAPY
AB Metabolic syndrome-mediated heart failure with preserved ejection fraction (HFpEF) is commonly accompanied by left atrial (LA) cardiomyopathy, significantly affecting morbidity and mortality. We evaluate the role of reactive oxygen species (ROS) and intrinsic inflammation (TNF-alpha, IL-10) related to dysfunctional Ca2+ homeostasis of LA cardiomyocytes in a rat model of metabolic HFpEF. ZFS-1 obese rats showed features of HFpEF and atrial cardiomyopathy in vivo: increased left ventricular (LV) mass, E/e' and LA size and preserved LV ejection fraction. In vitro, LA cardiomyocytes exhibited more mitochondrial-fission (MitoTracker) and ROS-production (H2DCF). In wildtype (WT), pro-inflammatory TNF-alpha impaired cellular Ca2+ homeostasis, while anti-inflammatory IL-10 had no notable effect (confocal microscopy; Fluo-4). In HFpEF, TNF-alpha had no effect on Ca2+ homeostasis associated with decreased TNF-alpha receptor expression (western blot). In addition, IL-10 substantially improved Ca2+ release and reuptake, while IL-10 receptor-1 expression was unaltered. Oxidative stress in metabolic syndrome mediated LA cardiomyopathy was increased and anti-inflammatory treatment positively affected dysfunctional Ca2+ homeostasis. Our data indicates, that patients with HFpEF-related LA dysfunction might profit from IL-10 targeted therapy, which should be further explored in preclinical trials.
C1 [Bode, David; Wen, Yan; Hegemann, Niklas; Primessnig, Uwe; Parwani, Abdul; Boldt, Leif-Hendrik; M. Pieske, Burkert; R. Heinzel, Frank; Hohendanner, Felix] Charite, Dept Internal Med & Cardiol, Campus Virchow Klinikum, D-13353 Berlin, Germany.
   [Bode, David; Hegemann, Niklas; Primessnig, Uwe; M. Pieske, Burkert; R. Heinzel, Frank; Hohendanner, Felix] German Ctr Cardiovasc Res DZHK, Partner Site Berlin, D-10785 Berlin, Germany.
   [Bode, David; Primessnig, Uwe; Hohendanner, Felix] Berlin Inst Hlth BIH, D-10178 Berlin, Germany.
   [M. Pieske, Burkert] German Heart Ctr Berlin, Dept Internal Med & Cardiol, D-13353 Berlin, Germany.
C3 Berlin Institute of Health; Free University of Berlin; Humboldt
   University of Berlin; Charite Universitatsmedizin Berlin; German Centre
   for Cardiovascular Research; Berlin Institute of Health; German Heart
   Center Berlin
RP Hohendanner, F (corresponding author), Charite, Dept Internal Med & Cardiol, Campus Virchow Klinikum, D-13353 Berlin, Germany.; Hohendanner, F (corresponding author), German Ctr Cardiovasc Res DZHK, Partner Site Berlin, D-10785 Berlin, Germany.; Hohendanner, F (corresponding author), Berlin Inst Hlth BIH, D-10178 Berlin, Germany.
EM david.bode@charite.de; wenyanxmu@outlook.com;
   niklas.hegemann@charite.de; uwe.primessnig@charite.de;
   abdul.parwani@charite.de; leif-hendrik.boldt@charite.de;
   burkert.pieske@charite.de; frank.heinzel@charite.de;
   felix.hohendanner@charite.de
RI Bode, David/M-7603-2015; Pieske, Burkert/M-8089-2016
OI Bode, David/0000-0003-4077-111X; Pieske, Burkert/0000-0002-6466-5306;
   Boldt, Leif-Hendrik/0000-0002-3320-0880; Heinzel, Frank
   R./0000-0002-4529-5282
FU Else-Kroner-Fresenius-Foundation; German Centre for Cardiovascular
   Research (DZHK); DZHK; Berlin Institute of Health; Charite University
   Medicine Berlin
FX This research was funded by the Else-Kroner-Fresenius-Foundation (F.H.)
   and the German Centre for Cardiovascular Research (DZHK; F.H.). The
   authors were supported by the DZHK (D.B., F.H.) and the Berlin Institute
   of Health (D.B., U.P., F.H.). The APC was funded by Charite University
   Medicine Berlin.
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NR 37
TC 23
Z9 23
U1 0
U2 9
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD SEP
PY 2020
VL 9
IS 9
AR 860
DI 10.3390/antiox9090860
PG 13
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA OG6YT
UT WOS:000582027800001
PM 32937823
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Lima, WG
   Martins-Santos, MES
   Chaves, VE
AF Lima, William Gustavo
   Soares Martins-Santos, Maria Emilia
   Chaves, Valeria Ernestania
TI Uric acid as a modulator of glucose and lipid metabolism
SO BIOCHIMIE
LA English
DT Review
DE Uric acid; Metabolic syndrome; Non-alcoholic fatty liver; Adipose
   tissue; Skeletal muscle
ID ACTIVATED PROTEIN-KINASE; LIVER XANTHINE-OXIDASE; DEHYDROGENASE TYPE D;
   OXIDATIVE STRESS; FATTY-LIVER; INSULIN-RESISTANCE; HEPATIC STEATOSIS;
   NITRIC-OXIDE; EVOLUTIONARY IMPLICATIONS; ANTIOXIDANT CAPACITY
AB In humans, uric acid is the final oxidation product of purine catabolism. The serum uric acid level is based on the balance between the absorption, production and excretion of purine. Uric acid is similarly produced in the liver, adipose tissue and muscle and is primarily excreted through the urinary tract. Several factors, including a high-fructose diet and the use of xenobiotics and alcohol, contribute to hyperuricaemia. Hyperuricaemia belongs to a cluster of metabolic and haemodynamic abnormalities, called metabolic syndrome, characterised by abdominal obesity, glucose intolerance, insulin resistance, dyslipidaemia and hypertension. Hyperuricaemia reduction in the Pound mouse or fructose-fed rats, as well as hyperuricaemia induction by uricase inhibition in rodents and studies using cell culture have suggested that uric acid plays an important role in the development of metabolic syndrome. These studies have shown that high uric acid levels regulate the oxidative stress, inflammation and enzymes associated with glucose and lipid metabolism, suggesting a mechanism for the impairment of metabolic homeo-stasis. Humans lacking uricase, the enzyme responsible for uric acid degradation, are susceptible to these effects. In this review, we summarise the current knowledge of the effects of uric acid on the regulation of metabolism, primarily focusing on liver, adipose tissue and skeletal muscle. (C) 2015 Elsevier B.V.
C1 [Lima, William Gustavo; Chaves, Valeria Ernestania] Univ Fed Sao Joao del Rei, Physiol Lab, Divinopolis, MG, Brazil.
   [Soares Martins-Santos, Maria Emilia] Univ Fed Sao Joao del Rei, Metab Biochem, Divinopolis, MG, Brazil.
C3 Universidade Federal de Sao Joao del-Rei; Universidade Federal de Sao
   Joao del-Rei
RP Chaves, VE (corresponding author), Ave Sebastiao Goncalves Coelho,400, BR-35501296 Divinopolis, MG, Brazil.
EM valeria.chaves@gmail.com
RI Chaves, Valéria/K-4022-2012; Santos, Maria Emília/MHR-4328-2025; Gustavo
   de Lima, William/C-9258-2018
OI Gustavo de Lima, William/0000-0001-8946-9363; Chaves, Valeria
   Ernestania/0000-0003-4026-8565
FU Federal University of Sao Joao del-Rei; Fundacao de Amparo a Pesquisa do
   estado de Minas Gerais (FAPEMIG)
FX The authors would like to thank Renato Helios Migliorini (in memoriam)
   for being an exemplary scientist and professor. This work was supported
   through funding from the Federal University of Sao Joao del-Rei. W.G.L.
   received a fellowship from the Fundacao de Amparo a Pesquisa do estado
   de Minas Gerais (FAPEMIG).
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NR 70
TC 196
Z9 217
U1 8
U2 86
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0300-9084
EI 1638-6183
J9 BIOCHIMIE
JI Biochimie
PD SEP
PY 2015
VL 116
BP 17
EP 23
DI 10.1016/j.biochi.2015.06.025
PG 7
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA CP9ZC
UT WOS:000360253400003
PM 26133655
DA 2025-06-11
ER

PT J
AU Santilli, F
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AF Santilli, F.
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   Liani, R.
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   Davi, G.
TI Platelet activation in obesity and metabolic syndrome
SO OBESITY REVIEWS
LA English
DT Article
DE Atherothrombosis; metabolic syndrome; obesity; platelets
ID INTIMA-MEDIA THICKNESS; LOW-DOSE ASPIRIN; BODY-MASS INDEX; ENDOTHELIAL
   PROGENITOR CELLS; NITRIC-OXIDE SYNTHESIS; NECROSIS-FACTOR-ALPHA; IN-VIVO
   FORMATION; OXIDATIVE STRESS; THROMBOXANE BIOSYNTHESIS; WEIGHT-LOSS
AB Obesity is associated with increased cardiovascular disease. Metabolic syndrome (MS) identifies substantial additional cardiovascular risk beyond the individual risk factors, and is a powerful predictor of cardiovascular events even regardless of body mass index, thus suggesting a common downstream pathway conferring increased cardiovascular risk. Platelet hyper-reactivity/activation plays a central role to accelerate atherothrombosis and is the result of the interaction among the features clustering in obesity and MS: insulin resistance, inflammation, oxidative stress, endothelial dysfunction. Interestingly, the same pathogenic events largely account for the less-than-expected response to antiplatelet agents, namely low-dose aspirin. The proposed explanations for this phenomenon, besides underdosing of drug and/or reduced bioavailability, subsequent to excess of adipose tissue, include enhanced platelet turnover, leading to unacetylated COX-1 and COX-2 in newly formed platelets as a source of aspirin-escaping thromboxane formation; extraplatelet sources of thromboxane, driven by inflammatory triggers; and enhanced lipid peroxidation, activating platelets with a mechanism bypassing COX-1 acetylation or limiting COX-isozyme acetylation by aspirin. This review will address the complex interactions between platelets and the pathogenic events occurring in obesity and MS, trying to translate this body of mechanistic information into a clinically relevant read-out, in order to establish novel strategies in the prevention/treatment of atherothrombosis.
C1 [Santilli, F.; Vazzana, N.; Liani, R.; Guagnano, M. T.; Davi, G.] Univ G dAnnunzio, Ctr Excellence Aging, Chieti, Italy.
C3 G d'Annunzio University of Chieti-Pescara
RP Davì, G (corresponding author), Univ G dAnnunzio, Ctr Excellence Aging, Via Colle Ara, I-66013 Chieti, Italy.
RI Santilli, Francesca/ABC-6243-2021; Liani, Rossella/AAC-1375-2021;
   GUAGNANO, MARIA TERESA/AAT-1701-2021; Davi, Giovanni/K-7659-2016
OI Liani, Rossella/0000-0002-1523-530X; Santilli,
   Francesca/0000-0002-4593-905X; Davi, Giovanni/0000-0002-3044-0870
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NR 157
TC 207
Z9 216
U1 0
U2 16
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1467-7881
EI 1467-789X
J9 OBES REV
JI Obes. Rev.
PD JAN
PY 2012
VL 13
IS 1
BP 27
EP 42
DI 10.1111/j.1467-789X.2011.00930.x
PG 16
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 862LN
UT WOS:000298092500004
PM 21917110
DA 2025-06-11
ER

PT J
AU Ohnon, W
   Wattanathorn, J
   Thukham-mee, W
   Muchimapura, S
   Wannanon, P
   Tong-un, T
AF Ohnon, Warhi
   Wattanathorn, Jintanaporn
   Thukham-mee, Wipawee
   Muchimapura, Supaporn
   Wannanon, Panakaporn
   Tong-un, Terdthai
TI The Combined Extract of Black Sticky Rice and Dill Improves Poststroke
   Cognitive Impairment in Metabolic Syndrome Condition
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Article
ID CEREBRAL-ISCHEMIA-REPERFUSION; MEMORY IMPAIRMENT; OXIDATIVE STRESS;
   STROKE; RISK; BRAIN; ANTHOCYANINS; SERUM; MICE; PROANTHOCYANIDIN
AB Despite the increase in cognitive deficit following stroke in metabolic syndrome (MetS) condition, the therapeutic strategy is still limited. Since oxidative stress and neuroinflammation play the crucial roles on the pathophysiology of aforementioned conditions, the cognitive enhancing effect of the combined extract of Oryza sativa and Anethum graveolens was considered based on their antioxidant, anti-inflammation, and neuroprotective effects together with the synergistic effect concept. Male Wistar rats weighing 180-220 g were induced metabolic syndrome-like condition by using a high-carbohydrate high-fat diet (HCHF diet). Then, reperfusion injury following cerebral ischemia was induced by the occlusion of right middle cerebral artery and treated with the combined extract of O. sativa and A. graveolens (OA extract) at doses of 0.5, 5, and 50 mg/kg BW once daily for 21 days. Spatial memory was assessed every 7 days throughout the experimental period. At the end of the study, neuron and glial fibrillary acidic protein- (GFAP-) positive cell densities, the oxidative stress status, AChE, and the expression of proinflammatory cytokines (TNF-alpha, IL-6) in the hippocampus were determined. The results showed that OA extract at all doses used in this study significantly improved memory together with the reductions of MDA, TNF-alpha, IL-6, AChE, and density of GFAP-positive cell but increased neuron density in the hippocampus. Taken together, OA is the potential cognitive enhancer in memory impairment following stroke in MetS condition. The possible underlying mechanism may occur partly via the reductions of oxidative stress status, GFAP-positive cell density, and neuroinflammatory cytokines such as TNF-alpha and IL-6 together with the suppression of AChE activity in the hippocampus. This study suggests that OA is the potential functional ingredient to improve the cognitive enhancer. However, further clinical research is required.
C1 [Ohnon, Warhi; Wattanathorn, Jintanaporn; Thukham-mee, Wipawee; Muchimapura, Supaporn; Wannanon, Panakaporn; Tong-un, Terdthai] Khon Kaen Univ, Fac Med, Dept Physiol, Khon Kaen 40002, Thailand.
   [Ohnon, Warhi] Khon Kaen Univ, Fac Med, Grad Sch, Neurosci Program, Khon Kaen 40002, Thailand.
   [Ohnon, Warhi; Wattanathorn, Jintanaporn; Thukham-mee, Wipawee; Muchimapura, Supaporn; Wannanon, Panakaporn; Tong-un, Terdthai] Khon Kaen Univ, Integrat Complementary Alternat Med Res & Dev Ctr, Khon Kaen 40002, Thailand.
   [Ohnon, Warhi; Wattanathorn, Jintanaporn; Muchimapura, Supaporn; Wannanon, Panakaporn; Tong-un, Terdthai] Khon Kaen Univ, Human High Performance & Hlth Promot Res Inst, Khon Kaen 40002, Thailand.
C3 Khon Kaen University; Khon Kaen University; Khon Kaen University; Khon
   Kaen University
RP Wattanathorn, J (corresponding author), Khon Kaen Univ, Fac Med, Dept Physiol, Khon Kaen 40002, Thailand.; Wattanathorn, J (corresponding author), Khon Kaen Univ, Integrat Complementary Alternat Med Res & Dev Ctr, Khon Kaen 40002, Thailand.; Wattanathorn, J (corresponding author), Khon Kaen Univ, Human High Performance & Hlth Promot Res Inst, Khon Kaen 40002, Thailand.
EM jinwat05@gmail.com
OI Wattanathorn, Jintanaporn/0000-0002-7383-2348; Ohn-on,
   Warin/0000-0001-6552-5850; Muchimapura, Supaporn/0000-0001-7756-1955;
   Tong-un, Terdthai/0000-0002-5286-0788
FU Integrative Complementary Alternative Medicine Research and Development
   Center in Research Institute for Human High Performance and Health
   Promotion, Khon Kaen University, Khon Kaen, Thailand; Invitation
   Research Grant of Faculty of Medicine of Khon Kaen University; Graduate
   School of Khon Kaen University [IN59126]
FX This study was supported by the Integrative Complementary Alternative
   Medicine Research and Development Center in Research Institute for Human
   High Performance and Health Promotion, Khon Kaen University, Khon Kaen,
   Thailand, Invitation Research Grant of Faculty of Medicine, and Graduate
   School of Khon Kaen University (Grant number IN59126).
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NR 61
TC 13
Z9 13
U1 1
U2 14
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PY 2019
VL 2019
AR 9089035
DI 10.1155/2019/9089035
PG 19
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA HO4TH
UT WOS:000460915000001
PM 30937145
OA Green Submitted, Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Robert, L
   Narcy, A
   Rayssiguier, Y
   Mazur, A
   Rémésy, C
AF Robert, Laetitia
   Narcy, Agnes
   Rayssiguier, Yves
   Mazur, Andrzej
   Remesy, Christian
TI Lipid metabolism and antioxidant status in sucrose vs. potato-fed rats
SO JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION
LA English
DT Article
DE potato; sucrose; carbohydrates; cardiovascular disease; antioxidant
   status
ID LOW-DENSITY-LIPOPROTEIN; VITAMIN-C; ENDOTHELIAL FUNCTION;
   INSULIN-RESISTANCE; DIETARY FRUCTOSE; OXIDATIVE STRESS; PLASMA;
   CHOLESTEROL; PEROXIDATION; CONSUMPTION
AB Objective: Consumption of high levels of simple carbohydrates is associated with several metabolic disorders in humans and in laboratory animals, including symptoms of an early stage of metabolic syndrome (syndrome X). This disorder has several cardiovascular risk factors, such as hypertriglyceridemia, and is associated with an increase in oxidative stress. In contrast to sucrose, potato, a source of complex carbohydrates and antioxidant micronutrients, was thought to improve lipid metabolism and antioxidant protection.
   Methods: We investigated the effects of diets containing i) complex dietary carbohydrates and antioxidant micronutrients (potato Solanum tuberosum L.), ii) complex carbohydrates (starch) and iii) a simple carbohydrate (sucrose) on lipid metabolism and antioxidant status in rats.
   Results: An increase in short chain fatty acid (SCFA) pools was observed in the cecum of rats fed a potato-based diet, resulting from an increase in all SCFAs, especially propionate (+360%, P < 0.0001). Feeding rats a potato-based diet for 3 weeks led to a decrease in cholesterol (- 37%, potato vs. control and - 32%, potato vs. sucrose) and triglycerides (-31%, potato vs. control and -43%, potato vs. sucrose) concentrations in triglyceride-rich lipoproteins (TGRLP) fractions. The antioxidant status was decreased by sucrose consumption and improved by potato consumption.
   Conclusions: Our present results suggest that consumption of complex carbohydrates (provided as cooked potatoes), in combination with different antioxidant micronutrients, may enhance the antioxidant defences and improve lipid metabolism, when compared with starch (complex carbohydrates) and to sucrose consumption (source of simple sugar). These effects limit oxidative stress and reduce the risk of developing the associated degenerative diseases, including cardiovascular disease, and could have potential in cardiovascular disease prevention.
C1 [Robert, Laetitia; Narcy, Agnes; Rayssiguier, Yves; Mazur, Andrzej; Remesy, Christian] INRA, Unit Nutr Humainc Equipe Stress Metab & Micronutr, Ctr Clermont Ferrand Theix, F-63122 St Genes Champanelle, France.
C3 INRAE
RP Mazur, A (corresponding author), INRA, Unit Nutr Humainc Equipe Stress Metab & Micronutr, Ctr Clermont Ferrand Theix, F-63122 St Genes Champanelle, France.
EM mazur@clermont.inra.fr
RI Mazur, Andre/AAG-9751-2020
OI Mazur, Andre/0000-0002-1067-5066
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NR 52
TC 27
Z9 32
U1 0
U2 16
PU AMER COLLEGE NUTRITION
PI CLEARWATER
PA 300 SOUTH DUNCAN AVENUE, STE 225, CLEARWATER, FL 33755 USA
SN 0731-5724
J9 J AM COLL NUTR
JI J. Am. Coll. Nutr.
PD FEB
PY 2008
VL 27
IS 1
BP 109
EP 116
DI 10.1080/07315724.2008.10719682
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 292VT
UT WOS:000255294900015
PM 18460489
DA 2025-06-11
ER

PT J
AU Nakagami, H
   Pang, ZD
   Shimosato, T
   Moritani, T
   Kurinami, H
   Koriyama, H
   Tenma, A
   Shimamura, M
   Morishita, R
AF Nakagami, Hironori
   Pang, Zhengda
   Shimosato, Takashi
   Moritani, Toshinori
   Kurinami, Hitomi
   Koriyama, Hiroshi
   Tenma, Akiko
   Shimamura, Munehisa
   Morishita, Ryuichi
TI The dipeptidyl peptidase-4 inhibitor teneligliptin improved endothelial
   dysfunction and insulin resistance in the SHR/NDmcr-cp rat model of
   metabolic syndrome
SO HYPERTENSION RESEARCH
LA English
DT Article
DE DPP-4 inhibitor; endothelial function; insulin resistance; SHRcp
ID TYPE-2 DIABETES-MELLITUS; SKELETAL-MUSCLE; IV INHIBITORS; OXIDATIVE
   STRESS; PROGENITOR CELLS; SITAGLIPTIN; RECEPTOR; HYPERTENSION;
   NEPHROPATHY
AB Diabetes mellitus, hypertension and metabolic syndrome are major risk factors for the occurrence of cardiovascular events. In this study, we used spontaneous hypertensive rat (SHR)/NDmcr-cp (cp/cp) (SHRcp) rats as a model for metabolic syndrome to examine the effects of dipeptidyl peptidase (DPP)-4 inhibition on hypertension, glucose metabolism and endothelial dysfunction. First, we confirmed that SHRcp rats showed very severe obesity, hypertension and endothelial dysfunction phenotypes from 14 to 54 weeks of age. Next, we examined whether the DPP-4 inhibitor teneligliptin (10 mg kg(-1) per day per os for 12 weeks) could modify any of these phenotypes. Treatment with teneligliptin significantly improved hyperglycemia and insulin resistance, as evidenced by an oral glucose tolerance test and homeostasis model assessment for insulin resistance, respectively. Teneligliptin showed no effects on systolic blood pressure or heart rate. In regard to endothelial function, the vasodilator response to acetylcholine was significantly impaired in SHRcp rats when compared with WKY rats. Long-term treatment with teneligliptin significantly attenuated endothelial dysfunction through the upregulation of endothelium-derived nitric oxide synthase mRNA. These results demonstrate that long-term treatment with teneligliptin significantly improved endothelial dysfunction and glucose metabolism in a rat model of metabolic syndrome, suggesting that teneligliptin treatment might be beneficial for patients with hypertension and/or diabetes.
C1 [Nakagami, Hironori; Kurinami, Hitomi; Koriyama, Hiroshi; Tenma, Akiko; Shimamura, Munehisa] Osaka Univ, Div Vasc Med & Epigenet, United Grad Sch Child Dev, Suita, Osaka 5650871, Japan.
   [Nakagami, Hironori; Kurinami, Hitomi; Koriyama, Hiroshi; Tenma, Akiko; Shimamura, Munehisa] Kanazawa Univ, Suita, Osaka 5650871, Japan.
   [Nakagami, Hironori; Kurinami, Hitomi; Koriyama, Hiroshi; Tenma, Akiko; Shimamura, Munehisa] Hamamatsu Univ Sch Med, Suita, Osaka 5650871, Japan.
   [Nakagami, Hironori; Kurinami, Hitomi; Koriyama, Hiroshi; Tenma, Akiko; Shimamura, Munehisa] Chiba Univ, Suita, Osaka 5650871, Japan.
   [Nakagami, Hironori; Kurinami, Hitomi; Koriyama, Hiroshi; Tenma, Akiko; Shimamura, Munehisa] Univ Fukui, Osaka, Japan.
   [Pang, Zhengda] Osaka Univ, Grad Sch Med, Dept Geriatr Med, Suita, Osaka 5650871, Japan.
   [Shimosato, Takashi; Moritani, Toshinori] NISSEI BILIS Co Ltd, Res Dept, Shiga, Japan.
   [Morishita, Ryuichi] Osaka Univ, Dept Clin Gene Therapy, Grad Sch Med, Suita, Osaka 5650871, Japan.
C3 The University of Osaka; Kanazawa University; Chiba University;
   University of Fukui; The University of Osaka; The University of Osaka
RP Nakagami, H (corresponding author), Osaka Univ, Div Vasc Med & Epigenet, Grad Sch Child Dev, 2-2 Yamada Oka, Suita, Osaka 5650871, Japan.
EM nakagami@cgt.med.osaka-u.ac.jp; morishit@cgt.med.osaka-u.ac.jp
RI Nakagami, Hironori/GLU-0570-2022
OI Nakagami, Hironori/0000-0003-4494-3601
FU Mitsubishi Tanabe; Takeda; Daiichi-Sankyo; AnGes MG; Novartis; Shionogi;
   Boeringher; Rohto; Baeyel; Kowa; Astrazeneca
FX We thank Ms Hizuki Hamada and Ms Yoko Horiguchi for their technical
   assistance, and Ms Satoe Kitabata for her help in office procedures.
   This study was partially supported by Mitsubishi Tanabe. The Department
   of Clinical Gene Therapy was financially supported by Takeda,
   Daiichi-Sankyo, AnGes MG, Novartis, Shionogi, Boeringher and Rohto. The
   Division of Vascular Medicine and Epigenetics was financially supported
   by Baeyel and partially supported by Kowa and Astrazeneca.
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NR 24
TC 31
Z9 33
U1 0
U2 6
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0916-9636
EI 1348-4214
J9 HYPERTENS RES
JI Hypertens. Res.
PD JUL
PY 2014
VL 37
IS 7
BP 629
EP 635
DI 10.1038/hr.2014.53
PG 7
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA AK8UO
UT WOS:000338704300005
PM 24621463
OA Bronze
DA 2025-06-11
ER

PT J
AU Yuan, F
   Woollard, JR
   Jordan, KL
   Lerman, A
   Lerman, LO
   Eirin, A
AF Yuan, Fang
   Woollard, John R.
   Jordan, Kyra L.
   Lerman, Amir
   Lerman, Lilach O.
   Eirin, Alfonso
TI Mitochondrial targeted peptides preserve mitochondrial organization and
   decrease reversible myocardial changes in early swine metabolic syndrome
SO CARDIOVASCULAR RESEARCH
LA English
DT Article
DE Metabolic syndrome; Mitochondria; Myocardium; Cytoskeleton; Elamipretide
ID RENAL-ARTERY STENOSIS; HEART-FAILURE; OXIDATIVE STRESS; RENOVASCULAR
   DISEASE; SKELETAL-MUSCLE; CARDIOLIPIN; OBESITY; HYPERTENSION;
   DYSFUNCTION; PROTEIN
AB The mechanisms responsible for cardiac damage in the early stages of metabolic syndrome (MetS) remain unknown. Mitochondria are intimately associated with cellular myofibrils, with the cytoskeleton functioning as a linkage coordinator, and closely associated to the calcium release sites of the sarcoplasmic reticulum (SR). We hypothesized that early MetS is characterized by mitochondria-related myocardial damage, associated with altered cytoskeletal-mitochondria-SR interaction.
   Domestic pigs were studied after 16 weeks of diet-induced MetS, MetS treated for the last 4 weeks with the mitochondrial-targeted peptide elamipretide (ELAM; 0.1 mg/kg SC q.d), or Lean controls (n = 6/group). Cardiac remodeling and function were assessed by fast comuted tomography. Myocardial mitochondrial structure, SR-mitochondria interaction, calcium handling, cytoskeletal proteins, oxidative stress, and apoptosis were studied ex-vivo. MetS pigs developed hyperlipidemia, hypertension, and insulin resistance, yet cardiac function was preserved. MetS-induced mitochondrial disorganization, decreased (C18:2)4 cardiolipin, disrupted ATP/ADP balance, and decreased cytochrome-c oxidase (COX)-IV activity. MetS also increased mitochondrial hydrogen peroxide (H2O2) production, decreased nicotinamide adenine dinucleotide phosphate (NADPH)/NADP and GSH/GSSG, and decreased myocardial desmin and beta 2 tubulin immunoreactivity, and impaired SR-mitochondrial interaction and mitochondrial calcium handling, eliciting myocardial oxidative stress and apoptosis. ELAM improved mitochondrial organization and cardiolipin species profile, restored ATP/ADP ratio and COX-IV activity, decreased H(2)0(2) production, and improved generation of NADPH and GSH. ELAM also improved cytoskeletal-mitochondria-SR interaction and mitochondrial calcium handling, attenuating oxidative stress, and apoptosis.
   Disorganization of cardiomyocyte cytoskeletal-mitochondria-SR network is associated with cardiac reversible changes in early MetS, preceding overt cardiac dysfunction. These findings may introduce novel therapeutic targets for blunting cardiac damage in early MetS.
C1 [Yuan, Fang; Woollard, John R.; Jordan, Kyra L.; Lerman, Lilach O.; Eirin, Alfonso] Mayo Clin, Dept Med, Div Nephrol & Hypertens, Rochester, MN 55905 USA.
   [Yuan, Fang] Zhengzhou Univ, Peoples Hosp, Dept Cardiol, Henan Prov Peoples Hosp, Zhengzhou, Henan, Peoples R China.
   [Lerman, Amir; Lerman, Lilach O.] Mayo Clin, Dept Cardiovasc Dis, Rochester, MN USA.
C3 Mayo Clinic; Zhengzhou University; Mayo Clinic
RP Eirin, A (corresponding author), Mayo Clin, Dept Med, Div Nephrol & Hypertens, Rochester, MN 55905 USA.
EM eirinmassat.alfonso@mayo.edu
RI Eirin, Alfonso/N-9873-2013; Lerman, Lilach/M-4962-2017
OI Eirin, Alfonso/0000-0002-3864-9644
FU Stealth BioTherapeutics, Inc.; National Institutes of Health [DK102325,
   DK106427, DK73608, HL123160, DK104273]
FX This work was supported by research grants from Stealth BioTherapeutics,
   Inc., and from the National Institutes of Health (DK106427, DK73608,
   DK104273, HL123160, and DK102325).
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NR 52
TC 22
Z9 24
U1 0
U2 4
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0008-6363
EI 1755-3245
J9 CARDIOVASC RES
JI Cardiovasc. Res.
PD MAR
PY 2018
VL 114
IS 3
BP 431
EP 442
DI 10.1093/cvr/cvx245
PG 12
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA FY4SC
UT WOS:000426815000016
PM 29267873
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Wang, H
   Xu, YX
   Qiu, CJ
AF Wang, Hui
   Xu, Yixin
   Qiu, Chunjian
TI Alterations of Thyroid Function and Nutritional Status in Patients with
   Type 2 Diabetes Mellitus Complicated by Metabolic Syndrome Treated with
   Insulin Combined with Either Liraglutide or Dapagliflozin
SO CURRENT TOPICS IN NUTRACEUTICAL RESEARCH
LA English
DT Article
DE Dapagliflozin; Liraglutide; Metabolic syndrome; Nutritional status; Type
   2 diabetes; Thyroid function
AB The present study compared the effectiveness of insulin plus liraglutide or dapagliflozin in treating type 2 diabetes mellitus complicated with metabolic syndrome and observed the nutritional status of patients before and after treatment. The results revealed no significant difference in the overall clinical efficacy and blood glucose levels between the liraglutide group treated with liraglutide and the dapagliflozin group treated with dapagliflozin (P > 0.05). In contrast, the adverse reactions in the liraglutide group were even lower than those in the control group (P < 0.05). In addition, the liraglutide group demonstrated better improvements in insulin metabolism and blood lipid levels than the dapagliflozin group after treatment. However, their ability to repair thyroid function and alleviate oxidative stress was comparatively weak (P < 0.05). Serum albumin, total protein, and transferrin levels were elevated in both groups after treatment, but the increase in the dapagliflozin group was higher than that in the liraglutide group (P < 0.05). The number of malnutrition cases was significantly reduced in both groups after treatment compared to before treatment (P < 0.05). These results suggest that the combination of insulin with liraglutide or dapagliflozin is highly effective in treating type 2 diabetes mellitus complicated by metabolic syndrome and can effectively improve the nutritional status of patients.
C1 [Wang, Hui] First Peoples Hosp ChuZhou, Dept Endocrinol, Chuzhou 239000, Peoples R China.
   [Xu, Yixin; Qiu, Chunjian] Nanjing Univ, Jinling Hosp, Dept Endocrinol, Nanjing 210002, Jiangsu, Peoples R China.
   [Xu, Yixin; Qiu, Chunjian] Nanjing Univ, Jinling Hosp, Dept Endocrinol, 305 Zhongshan East Rd, Nanjing 210002, Jiangsu, Peoples R China.
C3 Nanjing University; Nanjing University
RP Xu, YX; Qiu, CJ (corresponding author), Nanjing Univ, Jinling Hosp, Dept Endocrinol, 305 Zhongshan East Rd, Nanjing 210002, Jiangsu, Peoples R China.
EM xyxxyh2@163.com; qiuchunjian223@163.com
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NR 31
TC 0
Z9 0
U1 1
U2 2
PU NEW CENTURY HEALTH PUBLISHERS, LLC
PI COPPELL
PA PO BOX 175, COPPELL, TX 75019 USA
SN 1540-7535
EI 2641-452X
J9 CURR TOP NUTRACEUT R
JI Curr. Top. Nutraceutical Res.
PD FEB
PY 2024
VL 22
IS 1
BP 152
EP 159
DI 10.37290/ctnr2641-452X.22:152-159
PG 8
WC Nutrition & Dietetics; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics; Pharmacology & Pharmacy
GA KA5A7
UT WOS:001177241700026
DA 2025-06-11
ER

PT J
AU Wadolowska, L
   Danowska-Oziewicz, M
   Stewart-Knox, B
   de Almeida, MDV
AF Wadolowska, Lidia
   Danowska-Oziewicz, Marzena
   Stewart-Knox, Barbara
   Vaz de Almeida, Maria Daniel
TI Differences between older and younger Poles in functional food
   consumption, awareness of metabolic syndrome risk and perceived barriers
   to health improvement
SO FOOD POLICY
LA English
DT Article
DE The elderly; Functional food; Health improvement; Health perceptions;
   Metabolic syndrome
ID ATTITUDES; NUTRITION; DISEASE; LIFE
AB The aim of the study was to analyze the differences between older and younger Poles in functional food consumption, awareness of metabolic syndrome risk and perceived barriers to health improvement. A national representative sample of 1005 adults aged 15+ was selected for the study. The eldest age group (65+ years) more often than the youngest age group (15-24 years) reported having high blood cholesterol (OR = 12.30), high blood pressure (OR = 10.61), central obesity (OR = 7.94), high blood sugar (OR = 4.33), high stress level (OR = 2.12). A smaller number of the older in comparison to the younger consumed probiotic yoghurt drinks (OR = 0.48), foods with added vitamins and/or minerals (OR = 0.31), energy drinks (OR = 0.05) at least once a week. Younger people were more likely to report that they were ready to increase physical activity (OR = 0.21), cut down on or stop smoking (OR = 0.48) or drink less alcohol (OR = 0.46), but more of them would prefer to take medicines than food-related intervention (OR = 3.05). Older people rarely complained about a lack of time (OR = 0.26) to improve their health. In conclusion, intervention to promote a healthy lifestyle to prevent and treat metabolic syndrome would need to target older Poles. (C) 2009 Elsevier Ltd. All rights reserved.
C1 [Wadolowska, Lidia; Danowska-Oziewicz, Marzena] Univ Warmia & Mazury, Dept Human Nutr, PL-10718 Olsztyn, Poland.
   [Stewart-Knox, Barbara] Univ Ulster, No Ireland Ctr Food & Hlth, Coleraine BT52 1SA, Londonderry, North Ireland.
   [Vaz de Almeida, Maria Daniel] Univ Porto, Fac Nutr & Food Sci, P-4100 Oporto, Portugal.
C3 University of Warmia & Mazury; Ulster University; Universidade do Porto
RP Wadolowska, L (corresponding author), Univ Warmia & Mazury, Dept Human Nutr, Ul Sloneczna 44A, PL-10718 Olsztyn, Poland.
EM lidia.wadolowska@uwm.edu.pl
RI De+Almeida, Maria Daniel/AAE-3343-2022; Wądołowska, Lidia/L-1458-2019;
   Wadolowska, Lidia/O-8463-2018
OI Wadolowska, Lidia/0000-0001-8571-9935; Danowska-Oziewicz,
   Marzena/0000-0002-3880-4798; Stewart-Knox, Barbara/0000-0002-6741-3657
FU LIPGENE [FOOD-CT-2003505944];  [20042009]
FX The authors gratefully acknowledge funding by the EU 6th Framework Food
   Quality and Safety Program to collect this data. The study was carried
   out as a part of the LIPGENE project (code FOOD-CT-2003505944). This is
   an integrated project (20042009) entitled "Diet, genomics, and the
   metabolic syndrome: an integrated nutrition, agro-food, social and
   economics analysis".
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NR 43
TC 17
Z9 17
U1 0
U2 31
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0306-9192
EI 1873-5657
J9 FOOD POLICY
JI Food Policy
PD JUN
PY 2009
VL 34
IS 3
BP 311
EP 318
DI 10.1016/j.foodpol.2009.02.006
PG 8
WC Agricultural Economics & Policy; Economics; Food Science & Technology;
   Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Agriculture; Business & Economics; Food Science & Technology; Nutrition
   & Dietetics
GA 462KZ
UT WOS:000267352700011
DA 2025-06-11
ER

PT J
AU Hedayati, N
   Naeini, MB
   Mohammadinejad, A
   Mohajeri, SA
AF Hedayati, Narges
   Naeini, Mehri Bemani
   Mohammadinejad, Arash
   Mohajeri, Seyed Ahmad
TI Beneficial effects of celery (Apium graveolens) on metabolic
   syndrome: A review of the existing evidences
SO PHYTOTHERAPY RESEARCH
LA English
DT Review
DE Apium graveolens; dyslipidemia; hyperglycemia; hypertension; metabolic
   syndrome; obesity
ID SUPERCRITICAL ANTISOLVENT PROCESS; HYDROXYPROPYL-BETA-CYCLODEXTRIN;
   IN-VITRO; ORAL BIOAVAILABILITY; OXIDATIVE STRESS; INSULIN-RESISTANCE;
   INCLUSION COMPLEX; LIPID PROFILE; ESSENTIAL OIL; UP-REGULATION
AB The metabolic syndrome (MetS) is a cluster of multiple conditions that includes hypertension, dyslipidemia, abdominal obesity, and hyperglycemia disorders. Most studies revealed that the MetS is accompanied with an increased risk for cardiovascular disease, Type 2 diabetes mellitus, and insulin resistance. It can be said that, in treating or preventing the MetS and its components, lifestyle adjustment and weight loss have a vital role. According to various studies, among natural compounds, celery (Apium graveolens) is one of the most important sources of phytochemicals such as phenolic acids, flavones, flavonols, and antioxidants such as vitamin C, beta-carotene (Provitamin A), and manganese. These antioxidants have a role in decreasing the oxidative damage. The phytochemicals in celery decrease the activity of proinflammatory cytokines and prevent inflammation. Also, flavonoids in celery suppress cardiovascular inflammation. Oxidative stress and inflammation in the blood stream are the main risk factors in increasing cardiovascular disease, especially atherosclerosis. Celery phthalides leads to expanding of smooth muscle in the blood vessels and lower blood pressure. As a result, the most active ingredients in celery (A. graveolens (have shown hypolipidemic, antidiabetic, and hypotensive properties. In this review, we summarized the mechanisms underlying the protective effects of celery components on insulin action, glucose, lipid metabolism, and blood pressure.
C1 [Hedayati, Narges; Mohammadinejad, Arash; Mohajeri, Seyed Ahmad] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Pharmaceut Res Ctr, Mashhad, Razavi Khorasan, Iran.
   [Naeini, Mehri Bemani] Mashhad Univ Med Sci, Nanotechnol Res Ctr, Mashhad, Razavi Khorasan, Iran.
   [Mohammadinejad, Arash] Payame Noor Univ, Dept Chem, Tehran, Iran.
   [Hedayati, Narges; Mohammadinejad, Arash; Mohajeri, Seyed Ahmad] Mashhad Univ Med Sci, Sch Pharm, Dept Pharmacodynam & Toxicol, Mashhad, Razavi Khorasan, Iran.
C3 Mashhad University of Medical Sciences; Mashhad University of Medical
   Sciences; Payame Noor University; Mashhad University of Medical Sciences
RP Mohajeri, SA (corresponding author), Mashhad Univ Med Sci, Sch Pharm, Pharmaceut Res Ctr, Pharmacol, Mashhad, Razavi Khorasan, Iran.
EM mohajeria@mums.ac.ir
RI Mohajeri, Seyed/AAC-9715-2019; Mohammadinejad, Arash/GZL-2637-2022
OI Mohammadinejad, Arash/0000-0002-6805-1803
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NR 97
TC 38
Z9 41
U1 4
U2 36
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0951-418X
EI 1099-1573
J9 PHYTOTHER RES
JI Phytother. Res.
PD DEC
PY 2019
VL 33
IS 12
BP 3040
EP 3053
DI 10.1002/ptr.6492
EA AUG 2019
PG 14
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA KV5CL
UT WOS:000484622500001
PM 31464016
DA 2025-06-11
ER

PT J
AU Rentoukas, E
   Tsarouhas, K
   Kaplanis, I
   Korou, E
   Nikolaou, M
   Marathonitis, G
   Kokkinou, S
   Haliassos, A
   Mamalaki, A
   Kouretas, D
   Tsitsimpikou, C
AF Rentoukas, Elias
   Tsarouhas, Konstantinos
   Kaplanis, Ioannis
   Korou, Eleni
   Nikolaou, Maria
   Marathonitis, George
   Kokkinou, Stavroula
   Haliassos, Alexander
   Mamalaki, Avgi
   Kouretas, Demetrios
   Tsitsimpikou, Christina
TI Connection between Telomerase Activity in PBMC and Markers of
   Inflammation and Endothelial Dysfunction in Patients with Metabolic
   Syndrome
SO PLOS ONE
LA English
DT Article
ID ASYMMETRIC DIMETHYLARGININE ADMA; BLOOD MONONUCLEAR-CELLS; OXIDATIVE
   STRESS; NITRIC-OXIDE; ASSOCIATION; ATHEROSCLEROSIS; MECHANISMS;
   EXPRESSION; DISEASE; BIOLOGY
AB Metabolic syndrome (MS) is a constellation of metabolic derangements associated with vascular endothelial dysfunction and oxidative stress and is widely regarded as an inflammatory condition, accompanied by an increased risk for cardiovascular disease. The present study tried to investigate the implications of telomerase activity with inflammation and impaired endothelial function in patients with metabolic syndrome. Telomerase activity in circulating peripheral blood mononuclear cells (PBMC), TNF-alpha, IL-6 and ADMA were monitored in 39 patients with MS and 20 age and sex-matched healthy volunteers. Telomerase activity in PBMC, TNF-alpha, IL-6 and ADMA were all significantly elevated in patients with MS compared to healthy volunteers. PBMC telomerase was negatively correlated with HDL and positively correlated with ADMA, while no association between TNF-alpha and IL-6 was observed. IL-6 was increasing with increasing systolic pressure both in the patients with MS and in the healthy volunteers, while smoking and diabetes were positively correlated with IL-6 only in the patients' group. In conclusion, in patients with MS characterised by a strong dyslipidemic profile and low diabetes prevalence, significant telomerase activity was detected in circulating PBMC, along with elevated markers of inflammation and endothelial dysfunction. These findings suggest a prolonged activity of inflammatory cells in the studied state of this metabolic disorder that could represent a contributory pathway in the pathogenesis of atherosclerosis.
C1 [Rentoukas, Elias; Kaplanis, Ioannis; Korou, Eleni; Nikolaou, Maria] Amalia Fleming Gen Hosp, Cardiol Dept 2, Athens, Greece.
   [Tsarouhas, Konstantinos] Gen Hosp Karditsa, Div Cardiol, Terma Tavropou, Karditsa, Greece.
   [Marathonitis, George] Amalia Fleming Gen Hosp, Pathol Dept A, Athens, Greece.
   [Kokkinou, Stavroula] Sismanoglio Gen Hosp, Cytogenet Unit, Athens, Greece.
   [Haliassos, Alexander] Diamed Labs Dept SA, ESEAP Greek Proficiency Testing Scheme Lab Med, Athens, Greece.
   [Mamalaki, Avgi] Hellenic Pasteur Inst, Dept Biochem, Athens, Greece.
   [Kouretas, Demetrios] Univ Thessaly, Dept Biochem & Biotechnol, Larisa, Greece.
   [Tsitsimpikou, Christina] Gen Chem State Lab Greece, Athens, Greece.
C3 University of Thessaly
RP Rentoukas, E (corresponding author), Amalia Fleming Gen Hosp, Cardiol Dept 2, Athens, Greece.
EM chtsitsi@yahoo.com
RI KOURETAS, DEMETRIOS/ABE-8519-2020; Haliassos, Alexander/GYJ-3828-2022;
   Tsarouhas, Konstantinos/H-5793-2019
OI Tsarouhas, Konstantinos/0000-0003-2651-3579
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NR 37
TC 57
Z9 60
U1 1
U2 5
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD APR 25
PY 2012
VL 7
IS 4
AR e35739
DI 10.1371/journal.pone.0035739
PG 4
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 959VP
UT WOS:000305345200073
PM 22558213
OA gold, Green Accepted, Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Renna, NF
   Diez, ER
   Lembo, C
   Miatello, RM
AF Renna, Nicolas F.
   Diez, Emiliano R.
   Lembo, Carina
   Miatello, Roberto M.
TI Role of Cox-2 in Vascular Inflammation: An Experimental Model of
   Metabolic Syndrome
SO MEDIATORS OF INFLAMMATION
LA English
DT Article
ID NITRIC-OXIDE; SMOOTH-MUSCLE; INCREASED EXPRESSION; CELLS; RELAXATION;
   RESISTANCE; ARTERIES
AB The objective of this work was to demonstrate the role of COX-2 enzyme at the vascular in experimental model of metabolic syndrome. SHR male WKY rats were employed; they were distributed in 8 groups (n = 8 each): control (W); W + L: WKY rats receiving 20 mg/kg of lumiracoxib by intraesophageal administration; SHR; SHR + L: SHR + 20 mg/kg of lumiracoxib by intraesophageal administration; Fructose-Fed Rats (FFR): WKY rats receiving 10% (w/v) fructose solution in drinking water during all 12 weeks; FFR + L: FFR + 20 mg/kg of lumiracoxib by intraesophageal administration; Fructose-Fed Hypertensive Rats (FFHR): SHR receiving 10% (w/v) fructose solution in drinking water during all 12 weeks; and FFHR + L: FFHR + 20 mg/kg of lumiracoxib by intraesophageal administration. Metabolic variables, blood pressure, morphometric variables, and oxidative stress variables were evaluated; also MMP-2 and MMP-9 (collagenases), VCAM-1, and NF-kappa B by Westernblot or IFI were evaluated. FFHR presented all variables of metabolic syndrome; there was also an increase in oxidative stress variables; vascular remodeling and left ventricular hypertrophy were evidenced along with a significant increase in the expression of the mentioned proinflammatory molecules and increased activity and expression of collagenase. Lumiracoxib was able to reverse vascular remodeling changes and inflammation, demonstrating the involvement of COX-2 in the pathophysiology of vascular remodeling in this experimental model.
C1 [Renna, Nicolas F.; Miatello, Roberto M.] Natl Univ Cuyo, Sch Med, Dept Pathol, Ctr Univ, RA-5500 Mendoza, Argentina.
   [Renna, Nicolas F.; Diez, Emiliano R.; Lembo, Carina; Miatello, Roberto M.] Consejo Nacl Invest Cient & Tecn, Inst Expt Med & Biol Cuyo IMBECU, Mendoza, Argentina.
   [Diez, Emiliano R.] Natl Univ Cuyo, Sch Med, Dept Morphophysiol, Ctr Univ, RA-5500 Mendoza, Argentina.
C3 University Nacional Cuyo Mendoza; Consejo Nacional de Investigaciones
   Cientificas y Tecnicas (CONICET); Instituto de Medicina y BiologIa
   Experimental de Cuyo (IMBECU); University Nacional Cuyo Mendoza
RP Renna, NF (corresponding author), Natl Univ Cuyo, Sch Med, Dept Pathol, Ctr Univ, Ave Libertador 80, RA-5500 Mendoza, Argentina.
EM nicolasrenna@fcm.uncu.edu.ar
RI Diez, Emiliano/KIB-2439-2024
OI Diez, Emiliano/0000-0001-5163-3703
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NR 21
TC 18
Z9 19
U1 0
U2 3
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 0962-9351
EI 1466-1861
J9 MEDIAT INFLAMM
JI Mediat. Inflamm.
PY 2013
VL 2013
AR 513251
DI 10.1155/2013/513251
PG 10
WC Cell Biology; Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Immunology
GA 094AK
UT WOS:000315235000001
PM 23476105
OA gold, Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Janicke, DM
   Harman, JS
   Kelleher, KJ
   Zhang, J
AF Janicke, David M.
   Harman, Jeffrey S.
   Kelleher, Kelly J.
   Zhang, Jianyi
TI The Association of Psychiatric Diagnoses, Health Service Use, and
   Expenditures in Children with Obesity-related Health Conditions
SO JOURNAL OF PEDIATRIC PSYCHOLOGY
LA English
DT Article
ID PEER VICTIMIZATION; METABOLIC SYNDROME; PHYSICAL-ACTIVITY; OVERWEIGHT;
   ADOLESCENTS; DEPRESSION; PREVALENCE; CHILDHOOD; RATES
AB Objective To examine the association of psychiatric diagnoses and use of health care services in children with obesity-related health conditions. Method A retrospective, longitudinal design was used to examine Medicaid claims data. The data set consisted of 13,688 youth diagnosed with type 2 diabetes, metabolic syndrome, dyslipidemia, or obesity. Results The presence of any type of psychiatric diagnosis was associated with higher health service use. In particular, the presence of an internalizing diagnosis was more consistently associated with higher service use than the presence of an externalizing diagnosis. Children with both an externalizing and internalizing disorder diagnosis had greater service use than children with a diagnosis in only one of these categories. Conclusions These data highlight a subgroup of children with obesity-related health conditions who are at greater risk for higher health service use, and the need for further research on the association between psychiatric diagnosis and health service use.
C1 [Janicke, David M.] Univ Florida, Dept Clin & Hlth Psychol, Gainesville, FL 32610 USA.
   [Harman, Jeffrey S.] Univ Florida, Dept Hlth Serv Res Management & Policy, Gainesville, FL 32610 USA.
   [Kelleher, Kelly J.] Childrens Hosp, Dept Pediat & Publ Hlth, Boston, MA USA.
   [Zhang, Jianyi] Univ Florida, Ctr Medicaid, Gainesville, FL 32610 USA.
C3 State University System of Florida; University of Florida; State
   University System of Florida; University of Florida; Harvard University;
   Harvard University Medical Affiliates; Boston Children's Hospital; State
   University System of Florida; University of Florida; CMS Alliance to
   Modernize Healthcare; Centers for Medicare & Medicaid Services
RP Janicke, DM (corresponding author), Univ Florida, Dept Clin & Hlth Psychol, POB 100165, Gainesville, FL 32610 USA.
EM djanicke@phhp.ufl.edu
RI Kelleher, Kelly/E-3361-2011
OI Zhang, Jianyi/0000-0002-1501-4822; Janicke, David/0000-0002-8493-610X
CR BLENDON RJ, 1995, JAMA-J AM MED ASSOC, V273, P341, DOI 10.1001/jama.273.4.341
   de Ferranti SD, 2006, CLIN CHEM, V52, P1325, DOI 10.1373/clinchem.2006.067181
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NR 28
TC 15
Z9 17
U1 0
U2 9
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0146-8693
EI 1465-735X
J9 J PEDIATR PSYCHOL
JI J. Pediatr. Psychol.
PD JAN-FEB
PY 2009
VL 34
IS 1
BP 79
EP 88
DI 10.1093/jpepsy/jsn051
PG 10
WC Psychology, Developmental
WE Social Science Citation Index (SSCI)
SC Psychology
GA 392WW
UT WOS:000262333900011
PM 18522995
DA 2025-06-11
ER

PT J
AU Kim, BC
   Shin, A
   Hong, CW
   Sohn, DK
   Han, KS
   Ryu, KH
   Park, BJ
   Nam, JH
   Park, JW
   Chang, HJ
   Choi, HS
   Kim, J
   Oh, JH
AF Kim, Byung Chang
   Shin, Aesun
   Hong, Chang Won
   Sohn, Dae Kyung
   Han, Kyung Su
   Ryu, Kum Hei
   Park, Bum Joon
   Nam, Ji Hyung
   Park, Ji Won
   Chang, Hee Jin
   Choi, Hyo Seong
   Kim, Jeongseon
   Oh, Jae Hwan
TI Association of colorectal adenoma with components of metabolic syndrome
SO CANCER CAUSES & CONTROL
LA English
DT Article
DE Metabolic syndrome; Colorectal neoplasm; Obesity; Triglyceride
ID WHITE ADIPOSE-TISSUE; COLON-CANCER; SCREENING COLONOSCOPY; CHINESE
   POPULATION; PROSPECTIVE COHORT; RISK; INSULIN; GROWTH; KOREA; PREVALENCE
AB Recently, some studies have shown that diabetes mellitus and metabolic syndrome increase the risk of colorectal neoplasms. Although the mechanism is not known, those have been proposed to contribute to this phenomenon, including insulin resistance, oxidative stress, and adipokine production. The objective of this study was to assess the association between metabolic risk factors and colorectal neoplasm.
   Study participants visited the National Cancer Center, Korea, for screening (2007-2009). A total of 1,771 diagnosed adenoma patients and 4,667 polyp-free controls were included. The association between risk factors and colorectal neoplasm was evaluated using logistic regression models.
   High waist circumference, blood pressure, and serum triglyceride levels were associated with an increased risk of colorectal adenoma. Metabolic syndrome (MS) was associated with an increased risk of adenoma (OR = 1.44, 95 % CI = 1.23-1.70). The association between MS and colorectal adenoma was observed regardless of advanced/low-risk adenoma, and multiplicity. MS affected right colon adenomas (OR = 1.50, 95 % CI = 1.22-1.85), left colon adenomas (OR = 1.36, 95 % CI = 1.05-1.76), and adenomas in multiple anatomical locations (OR = 1.59, 95 % CI = 1.19-2.12), but was not associated with rectum.
   Central obesity, triglyceride level, and MS are risk factors for colorectal adenoma including advanced adenoma and multiplicity.
C1 [Hong, Chang Won] Natl Canc Ctr, Res Inst & Hosp, Ctr Colorectal Canc, Ctr Canc Prevent & Detect, Goyang Si 410769, Gyeonggi Do, South Korea.
   [Shin, Aesun; Kim, Jeongseon] Natl Canc Ctr, Res Inst, Canc Epidemiol Branch, Goyang Si 410769, Gyeonggi Do, South Korea.
   [Kim, Byung Chang; Hong, Chang Won; Sohn, Dae Kyung; Han, Kyung Su; Ryu, Kum Hei; Park, Bum Joon; Nam, Ji Hyung] Natl Canc Ctr Hosp, Ctr Canc Prevent & Detect, Goyang Si, South Korea.
C3 National Cancer Center - Korea (NCC); National Cancer Center - Korea
   (NCC); National Cancer Center - Korea (NCC)
RP Hong, CW (corresponding author), Natl Canc Ctr, Res Inst & Hosp, Ctr Colorectal Canc, Ctr Canc Prevent & Detect, 809 Madu 1 Dong, Goyang Si 410769, Gyeonggi Do, South Korea.
EM hong@ncc.re.kr
RI KIM, JEONGSEON/AAA-4643-2022; Park, Ji Won/JCD-9105-2023; park,
   bum-joon/LCD-8534-2024; Shin, Aesun/E-9145-2014
FU National Cancer Center, Korea [NCC-0910160, NCC-0710360, NCC-0910220]
FX This study was supported in part by grants NCC-0910160 (H. J. C),
   NCC-0710360 (C. W. H), and NCC-0910220 (A. S) from the National Cancer
   Center, Korea. The authors thank Jeong-Hee Lee, MS for her help in
   manuscript preparation.
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NR 38
TC 68
Z9 75
U1 0
U2 10
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0957-5243
J9 CANCER CAUSE CONTROL
JI Cancer Causes Control
PD MAY
PY 2012
VL 23
IS 5
BP 727
EP 735
DI 10.1007/s10552-012-9942-9
PG 9
WC Oncology; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Public, Environmental & Occupational Health
GA 934CI
UT WOS:000303418200008
PM 22450737
DA 2025-06-11
ER

PT J
AU Qi, XY
   Wang, SJ
   Huang, QW
   Chen, XB
   Qiu, LX
   Ouyang, KF
   Chen, YJ
AF Qi, Xiaoyi
   Wang, Shijia
   Huang, Qianwen
   Chen, Xiongbiao
   Qiu, Liangxian
   Ouyang, Kunfu
   Chen, Yanjun
TI The association between non-high-density lipoprotein cholesterol to
   high-density lipoprotein cholesterol ratio (NHHR) and risk of depression
   among US adults: A cross-sectional NHANES study
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE NHHR; Depression; NHANES; Cross-sectional study
ID METABOLIC SYNDROME; NATIONAL-HEALTH; SYMPTOMS
AB Background: NHHR (non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio) is a new lipid parameter used to assess the risk of cardiovascular disease. However, the association between NHHR and the risk of depression has not been studied before. Methods: We conducted a cross-sectional study using datasets from the National Health and Nutrition Examination Survey (NHANES) 2005-2016. The PHQ-9 questionnaire was used to evaluate depression. A weighted multivariable logistic regression model and a restricted cubic spline (RCS) model were applied to investigate the association between NHHR and depression risk. Additionally, subgroup and sensitivity analyses were conducted to test the robustness of the results. Results: In the total population, compared with the lowest reference group of NHHR, participants in the fourth quartile had a significantly increased risk of depression after full adjustments (OR: 1.61, 95%CI: 1.05-2.49). A linear dose-response relationship existed between NHHR and depression risk (P non-linearity = 0.264). The association remained significant in several subgroup analyses. Limitations: The cross-sectional design and use of self-reported scales. Conclusion: NHHR was significantly associated with a higher risk of depression in U.S. adults. Additional research on NHHR would help in depression prevention and treatment.
C1 [Qi, Xiaoyi; Wang, Shijia; Huang, Qianwen; Chen, Xiongbiao; Qiu, Liangxian; Chen, Yanjun] Peking Univ, Shenzhen Hosp, Dept Cardiol, Shenzhen, Peoples R China.
   [Qi, Xiaoyi] Shantou Univ, Med Coll, Shantou, Peoples R China.
   [Ouyang, Kunfu] Peking Univ, Shenzhen Grad Sch, Sch Chem Biol & Biotechnol, State Key Lab Chem Oncogen,Dept Cardiovasc Surg,Sh, Shenzhen, Peoples R China.
   [Chen, Yanjun] Peking Univ, Shenzhen Hosp, Dept Cardiol, 1120 Lianhua Rd, Shenzhen, Peoples R China.
C3 Peking University; Shantou University; Peking University; Peking
   University
RP Chen, YJ (corresponding author), Peking Univ, Shenzhen Hosp, Dept Cardiol, 1120 Lianhua Rd, Shenzhen, Peoples R China.
EM chenyanjunhyd@163.com
RI ouyang, kunfu/B-3073-2011; xiaoyi, Qi/HKM-8712-2023; Huang,
   Qianwen/AEW-1080-2022
OI Qi, xiaoyi/0000-0003-2611-4076
FU Shenzhen Science and Technology Innovation Foundation
   [JCYJ20180228162359914]; Guangdong-Shenzhen Joint Fund Youth Project
   [2021A1515111110]
FX This research was supported by Shenzhen Science and Technology
   Innovation Foundation (No. JCYJ20180228162359914) and Guangdong-Shenzhen
   Joint Fund Youth Project (No. 2021A1515111110).
CR Akbaraly TN, 2009, DIABETES CARE, V32, P499, DOI 10.2337/dc08-1358
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   Zhu L, 2015, KARDIOL POL, V73, P931, DOI 10.5603/KP.a2015.0086
NR 27
TC 74
Z9 74
U1 22
U2 57
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD JAN 1
PY 2024
VL 344
BP 451
EP 457
DI 10.1016/j.jad.2023.10.064
EA OCT 2023
PG 7
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA Y0NC4
UT WOS:001102312700001
PM 37838268
HC Y
HP Y
DA 2025-06-11
ER

PT J
AU Chen, MZ
   Wong, MWK
   Lim, JY
   Merchant, RA
AF Chen, M. Z.
   Wong, M. W. K.
   Lim, J. Y.
   Merchant, Reshma Aziz
TI Frailty and Quality of Life in Older Adults with Metabolic Syndrome -
   Findings from the Healthy Older People Everyday (HOPE) Study
SO JOURNAL OF NUTRITION HEALTH & AGING
LA English
DT Article
DE Frailty; metabolic syndrome; quality of life; activities of daily
   living; depression
ID CORONARY-ARTERY-DISEASE; DECLINE
AB Objectives Metabolic syndrome (MetS) and frailty are both associated with increased morbidity and mortality. Frailty is associated with reduced quality of life (QoL) but association of QoL with MetS have produced mixed results suggesting that other factors such as disease burden, obesity and depression may have a more significant influence. We aim to investigate the demographics of frail participants with MetS, and relationship between frailty and QoL in MetS. Methods Cross-sectional population study involving 292 older adults >= 65 years with MetS. MetS was defined using the Modified ATP III for Asians which requires the presence of 3 or more of the following 5 components 1) waist circumference >= 90cm for males or >= 80cm for females, 2) TG >= 150mg/dL, 3) HDLc < 40mg/dL in males or < 50mg/dL in females, 4) blood pressure >= 130/85mmHg or use of anti-hypertensive medication, and 5) fasting plasma glucose >= 100mg/dL or use of pharmacological treatment for diabetes mellitus. Data were collected on demographics, frailty (FRAIL), QoL (Euroqol-5D), perceived health, functional status, cognition, Timed-Up-and-Go (TUG), and hand-grip strength (HGS). Results 40.4% of the participants were pre-frail (MetSprefrail) and 7.2% were frail (MetSfrail). MetSfrail were significantly older, had lower education level, higher polypharmacy burden and higher prevalence of diabetes. The prevalence of at least 1 activity of daily living impairment was 4 times higher, and depression 9 times higher than their robust counterparts. MetSfrail also had longer TUG, higher prevalence of poor grip strength and poor perceived health. After adjusting for age, gender and education, MetSfrail was significantly associated with much higher odds of EQ-5D moderate to extreme problems with mobility (Odds Ratio (OR) =10.99, CI 2.62-46.14), usual activities (OR=37.82, CI 3.77-379.04) and pain (OR=10.79, CI 3.18-36.62). EQ-5D Index Value and Perceived Health improved by 0.1 (Mean Difference (MD) =0.07, CI 0.04-0.10) and 6.0 (MD=6.01, CI 3.29-8.73) respectively as frailty status improved. Conclusion Frailty in MetS is associated with depression, polypharmacy, greater functional impairment, poorer QoL and perceived health. Frailty screening and personalized management is crucial in MetS as frailty may be a mediator for negative outcomes in MetS, and frailty may be reversible.
C1 [Chen, M. Z.; Merchant, Reshma Aziz] Natl Univ Singapore Hosp, Div Geriatr Med, Dept Med, Singapore 119228, Singapore.
   [Wong, M. W. K.; Lim, J. Y.; Merchant, Reshma Aziz] Natl Univ Singapore, Dept Med, Yong Loo Lin Sch Med, Singapore, Singapore.
C3 National University of Singapore; National University of Singapore
RP Merchant, RA (corresponding author), Natl Univ Singapore Hosp, Div Geriatr Med, Dept Med, Singapore 119228, Singapore.
EM reshmaa@nuhs.edu.sg
RI Merchant, Reshma/ABD-4044-2020
OI Chen, Matthew Zhixuan/0000-0003-1408-7103; Merchant, Reshma
   Aziz/0000-0002-9032-0184
CR Angioni, 2020, J NUTR HEALTH AGING
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NR 48
TC 18
Z9 19
U1 0
U2 10
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1279-7707
EI 1760-4788
J9 J NUTR HEALTH AGING
JI J. Nutr. Health Aging
PD MAY
PY 2021
VL 25
IS 5
BP 637
EP 644
DI 10.1007/s12603-021-1609-3
EA MAR 2021
PG 8
WC Geriatrics & Gerontology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Nutrition & Dietetics
GA RX2UV
UT WOS:000625075800002
PM 33949631
OA hybrid
DA 2025-06-11
ER

PT J
AU Visser, AW
   de Mutsert, R
   le Cessie, S
   den Heijer, M
   Rosendaal, FR
   Kloppenburg, M
AF Visser, A. W.
   de Mutsert, R.
   le Cessie, S.
   den Heijer, M.
   Rosendaal, F. R.
   Kloppenburg, M.
CA NEO Study Grp
TI The relative contribution of mechanical stress and systemic processes in
   different types of osteoarthritis: the NEO study
SO ANNALS OF THE RHEUMATIC DISEASES
LA English
DT Article
ID METABOLIC RISK-FACTORS; BODY-FAT DISTRIBUTION; FOOT-TO-FOOT; KNEE
   OSTEOARTHRITIS; HAND OSTEOARTHRITIS; ADIPOSE-TISSUE; GENERAL-POPULATION;
   INSULIN-RESISTANCE; ASSOCIATION; OBESITY
AB Objective To study the relative contribution of surrogates for mechanical stress and systemic processes with osteoarthritis (OA) in weight-bearing and non-weight-bearing joints.
   Methods The Netherlands Epidemiology of Obesity study is a population-based cohort including 6673 participants (range 45-65 years, 56% women, median body mass index 26 kg/m(2)). Weight (kg) and fat mass (kg) were measured, fat-free mass (kg) was calculated. The metabolic syndrome was defined following the Adult Treatment Panel III criteria. Knee and hand OA were defined according to the American College of Rheumatology clinical criteria.
   Logistic regression analyses were performed to associate surrogates for mechanical stress (such as weight, fat-free mass) and systemic processes (such as metabolic syndrome) with OA in knees alone, knees and hands or hands alone, adjusted for age, sex, height, smoking, education and ethnicity, and when appropriate for metabolic factors and weight.
   Results Knee, knee and hand, and hand OA were present in 10%, 4% and 8% of the participants, respectively. Knee OA was associated with weight and fat-free mass, adjusted for metabolic factors (OR 1.49 (95% CI 1.32 to 1.68) and 2.05 (1.60 to 2.62), respectively). Similar results were found for OA in knees and hands (OR 1.51 (95% CI 1.29 to 1.78) and 2.17 (95% CI 1.52 to 3.10) respectively). Hand OA was associated with the metabolic syndrome, adjusted for weight (OR 1.46 (95% CI 1.06 to 2.02)).
   Conclusions In knee OA, whether or not in co-occurrence with hand OA, surrogates for mechanical stress are suggested to be the most important risk factors, whereas in hand OA alone, surrogates for systemic processes are the most important risk factors.
C1 [Visser, A. W.; Kloppenburg, M.] Leiden Univ, Med Ctr, Dept Rheumatol, NL-2300 RC Leiden, Netherlands.
   [de Mutsert, R.; le Cessie, S.; den Heijer, M.; Rosendaal, F. R.; Kloppenburg, M.] Leiden Univ, Med Ctr, Dept Clin Epidemiol, NL-2300 RC Leiden, Netherlands.
   [le Cessie, S.] Leiden Univ, Med Ctr, Dept Med Stat & Bioinformat, NL-2300 RC Leiden, Netherlands.
   [den Heijer, M.] Vrije Univ Amsterdam, Med Ctr, Dept Endocrinol, Amsterdam, Netherlands.
   [Rosendaal, F. R.] Leiden Univ, Med Ctr, Dept Thrombosis & Hemostasis, NL-2300 RC Leiden, Netherlands.
C3 Leiden University; Leiden University Medical Center (LUMC); Leiden
   University - Excl LUMC; Leiden University - Excl LUMC; Leiden
   University; Leiden University Medical Center (LUMC); Leiden University;
   Leiden University Medical Center (LUMC); Leiden University - Excl LUMC;
   Vrije Universiteit Amsterdam; Leiden University - Excl LUMC; Leiden
   University; Leiden University Medical Center (LUMC)
RP Visser, AW (corresponding author), Leiden Univ, Med Ctr, Dept Rheumatol, C1-R,POB 9600, NL-2300 RC Leiden, Netherlands.
EM a.w.visser@lumc.nl
RI Kloppenburg, Margreet/HMD-6815-2023; le+Cessie, Saskia/HGC-8966-2022;
   Rosendaal, Frits/Q-3842-2017; de Vries, Aiko/J-5397-2015; Rabelink,
   Ton/A-5316-2008
OI de Vries, Aiko/0000-0002-9284-3595; Rabelink, Ton/0000-0001-6780-5186
FU Dutch Arthritis Foundation
FX The NEO study is supported by the Dutch Arthritis Foundation, the
   participating Departments, the Division and the Board of Directors of
   the Leiden University Medical Center, and by the Leiden University,
   Research Profile Area 'Vascular and Regenerative Medicine'.
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NR 50
TC 141
Z9 144
U1 1
U2 25
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 0003-4967
EI 1468-2060
J9 ANN RHEUM DIS
JI Ann. Rheum. Dis.
PD OCT
PY 2015
VL 74
IS 10
BP 1842
EP 1847
DI 10.1136/annrheumdis-2013-205012
PG 6
WC Rheumatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Rheumatology
GA CR0WC
UT WOS:000361043200012
DA 2025-06-11
ER

PT J
AU Toblli, JE
   Cao, G
   Giani, JF
   Muñoz, MC
   Angerosa, M
   Dominici, FP
AF Toblli, Jorge E.
   Cao, Gabriel
   Giani, Jorge F.
   Munoz, Marina C.
   Angerosa, Margarita
   Dominici, Fernando P.
TI Long-term treatment with nebivolol attenuates renal damage in Zucker
   diabetic fatty rats
SO JOURNAL OF HYPERTENSION
LA English
DT Article
DE beta-blockers; chronic kidney disease; metabolic syndrome; oxidative
   stress
ID ENDOTHELIAL DYSFUNCTION; METABOLIC SYNDROME; INSULIN-RESISTANCE;
   NITRIC-OXIDE; OXIDATIVE STRESS; HYPERTENSION; OBESITY; INJURY;
   NEPHROPATHY; PROGRESSION
AB Objective Atenolol, a first-generation beta-blocker, effectively reduces blood pressure, although its use in metabolic syndrome remains controversial. Accordingly, this study evaluated the renal effects of nebivolol, a third-generation beta-blocker with additional vasodilating activity, versus those of atenolol in an animal model of diabetic nephropathy.
   Methods Zucker diabetic fatty (ZDF) rats and control lean Zucker rats (LZRs) were treated for 6 months with either nebivolol or atenolol. Blood pressure, circulating insulin, triglycerides, cholesterol and glucose, as well as proteinuria and creatinine clearance were evaluated. Thiobarbituric acid-reactive species, reduced glutathione (GSH)/oxidized glutathione (GSSG) ratio, CuZn superoxide dismutase, catalase and glutathione peroxidase were determined as biomarkers of oxidative stress in kidney homogenates. Expression of transforming growth factor-beta 1 (TGF-beta 1), alpha-smooth muscle actin (alpha-SMA), collagen type I and III, plasminogen activator inhibitor-1 (PAI-1), vascular and platelet endothelial cell adhesion molecule-1 (VCAM-1 and PECAM-1, respectively) were determined by immunohistochemistry. Fibrosis was evaluated by light microscopy.
   Results Both drugs induced a similar control of blood pressure throughout the study. Contrary to atenolol, nebivolol showed a beneficial impact on lipid profile, preserved glomerular filtration rate, reduced proteinuria and induced a positive regulation of structural podocyte proteins (nephrin and podocin) expression. Additionally nebivolol decreased oxidative stress biomarkers, induced a substantial reduction in the accumulation of extracellular matrix proteins, down-regulated the renal expression of VCAM-1, monocyte chemotactic protein-1 (MCP-1), ED1, alpha-SMA, TGF-beta 1 and PAI-1 and up-regulated the expression of PECAM-1.
   Conclusion Our current finding underscores the importance of this therapy in hypertensive states concomitant with altered lipid and glucose metabolism. J Hypertens 29: 1613-1623 (C) 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins.
C1 [Toblli, Jorge E.; Cao, Gabriel; Angerosa, Margarita] Hosp Aleman, Lab Expt Med, RA-1118 Buenos Aires, DF, Argentina.
   [Giani, Jorge F.; Munoz, Marina C.; Dominici, Fernando P.] Univ Buenos Aires, Fac Farm & Bioquim, Inst Quim & Fisicoquim Biol, Buenos Aires, DF, Argentina.
C3 University of Buenos Aires; University of Buenos Aires Hospital;
   Hospital Aleman; University of Buenos Aires
RP Toblli, JE (corresponding author), Hosp Aleman, Lab Expt Med, Av Pueyrredon 1640, RA-1118 Buenos Aires, DF, Argentina.
EM jorgetoblli@fibertel.com.ar
RI Cao, Gabriel/LJL-8755-2024
OI Dominici, Fernando Pablo/0000-0002-4351-0057; Cao,
   Gabriel/0000-0003-4671-9048; Giani, Jorge/0000-0003-0481-6595
FU University of Buenos Aires (UBACyT) [B051, M071]; National Council for
   Scientific Research of Argentina (CONICET) [PIP 114-200801-00374]
FX The study was partially supported by the University of Buenos Aires
   (UBACyT, B051 to F. P. D. and M071 to J.E.T.) and by the National
   Council for Scientific Research of Argentina (CONICET) through PIP
   114-200801-00374 (to F.P.D.).
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NR 55
TC 19
Z9 22
U1 0
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0263-6352
EI 1473-5598
J9 J HYPERTENS
JI J. Hypertens.
PD AUG
PY 2011
VL 29
IS 8
BP 1613
EP 1623
DI 10.1097/HJH.0b013e328349064c
PG 11
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 791TL
UT WOS:000292688400020
PM 21720265
DA 2025-06-11
ER

PT J
AU González-Castelazo, F
   Soria-Jasso, LE
   Torre-Villalvazo, I
   Cariño-Cortés, R
   Muñoz-Pérez, VM
   Ortiz, MI
   Fernández-Martínez, E
AF Gonzalez-Castelazo, Fabiola
   Soria-Jasso, Luis E.
   Torre-Villalvazo, Ivan
   Carino-Cortes, Raquel
   Munoz-Perez, Victor M.
   Ortiz, Mario I.
   Fernandez-Martinez, Eduardo
TI Plants of the Rubiaceae Family with Effect on Metabolic Syndrome:
   Constituents, Pharmacology, and Molecular Targets
SO PLANTS-BASEL
LA English
DT Review
DE diabetes; dyslipidemias; hypertension; medicinal plants; metabolic
   syndrome; Rubiaceae
ID FREE FATTY-ACIDS; HAMELIA-PATENS; AQUEOUS EXTRACT; ANTIINFLAMMATORY
   ACTIVITY; HYPOGLYCEMIC ACTIVITY; BOUVARDIA-TERNIFLORA;
   HINTONIA-STANDLEYANA; INSULIN-RESISTANCE; DISEASE; LATIFLORA
AB Metabolic syndrome (MetS) predisposes individuals to chronic non-communicable diseases (NCDs) like type 2 diabetes (T2D), non-alcoholic fatty liver disease, atherosclerosis, and cardiovascular disorders caused by systemic inflammation, intestinal dysbiosis, and diminished antioxidant ability, leading to oxidative stress and compromised insulin sensitivity across vital organs. NCDs present a global health challenge characterized by lengthy and costly pharmacological treatments. Complementary and alternative medicine using herbal therapies has gained popularity. Approximately 350,000 plant species are considered medicinal, with 80% of the world's population opting for traditional remedies; however, only 21,000 plants are scientifically confirmed by the WHO. The Rubiaceae family is promissory for preventing and treating MetS and associated NCDs due to its rich content of metabolites renowned for their antioxidative, anti-inflammatory, and metabolic regulatory properties. These compounds influence transcription factors and mitigate chronic low-grade inflammation, liver lipotoxicity, oxidative stress, and insulin resistance, making them a cost-effective non-pharmacological approach for MetS prevention and treatment. This review aims to collect and update data that validate the traditional uses of the Rubiaceae family for treating MetS and associated NCDs from experimental models and human subjects, highlighting the mechanisms through which their extracts and metabolites modulate glucose and lipid metabolism at the molecular, biochemical, and physiological levels.
C1 [Gonzalez-Castelazo, Fabiola; Soria-Jasso, Luis E.; Carino-Cortes, Raquel; Munoz-Perez, Victor M.; Ortiz, Mario I.; Fernandez-Martinez, Eduardo] Autonomous Univ Hidalgo State, Sch Hlth Sci, Dept Med, Lab Med Chem & Pharmacol,Ctr Res Reprod Biol, Pachuca 42090, Mexico.
   [Torre-Villalvazo, Ivan] Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Fisiol Nutr, Mexico City 14080, Mexico.
C3 Universidad Autonoma del Estado de Hidalgo; Instituto Nacional de
   Ciencias Medicas y Nutricion Salvador Zubiran - Mexico
RP Cariño-Cortés, R; Fernández-Martínez, E (corresponding author), Autonomous Univ Hidalgo State, Sch Hlth Sci, Dept Med, Lab Med Chem & Pharmacol,Ctr Res Reprod Biol, Pachuca 42090, Mexico.
EM fabiola.glz.castelazo@gmail.com; soriajasso@gmail.com;
   ivan.torrev@incmnsz.mx; raquelcarcortes@gmail.com;
   victor9783@hotmail.com; mario_i_ortiz@hotmail.com; tomedyfm@hotmail.com
RI Ortiz, Mario/A-7439-2015; Fernández-Martínez, Eduardo/AAJ-4920-2020;
   Cariño-Cortes, Raquel/E-5302-2018; Torre-Villalvazo, Ivan/M-2497-2014
OI Fernandez-Martinez, Eduardo/0000-0003-3280-1323; Carino-Cortes,
   Raquel/0000-0003-4776-3534; Munoz-Perez, Victor
   Manuel/0000-0003-1820-0839; Ortiz, Mario I./0000-0003-1047-6304;
   Torre-Villalvazo, Ivan/0000-0001-7412-1153
CR [Anonymous], 2015, Pharmacol. Online
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NR 81
TC 6
Z9 6
U1 1
U2 10
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 2223-7747
J9 PLANTS-BASEL
JI Plants-Basel
PD OCT
PY 2023
VL 12
IS 20
AR 3583
DI 10.3390/plants12203583
PG 19
WC Plant Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences
GA W9XM9
UT WOS:001095088300001
PM 37896046
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Özdogan, S
   Kaman, D
   Simsek, BÇ
AF Ozdogan, Serhat
   Kaman, Dilara
   Simsek, Bengu Cobanoglu
TI RETRACTED: Effects of coenzyme Q10 and α-lipoic acid supplementation in
   fructose fed rats (Retracted Article)
SO JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION
LA English
DT Article; Retracted Publication
DE metabolic syndrome; coenzyme Q10; alpha-lipoic acid; ADMA; oxidative
   stress
ID NITRIC-OXIDE SYNTHASE; PLASMA ASYMMETRIC DIMETHYLARGININE;
   CORONARY-ARTERY-DISEASE; STAGE RENAL-DISEASE; OXIDATIVE STRESS;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; ENDOTHELIAL DYSFUNCTION;
   CARDIOVASCULAR-DISEASE; LIPID-PEROXIDATION
AB This study was conducted to investigate the effects of alpha-lipoic acid and coenzyme Q10 on plasma levels of lipids, asymmetric dimethylarginine, oxidative stress in fructose fed rats which provide a model of dietary-induced insulin resistance and to evaluate vascular changes developing in these rats by histologically. Male Sprague Dawley rats were used in this study. The animals were divided into 4 groups. Group 1 did not receive any medication and served as a control. Group 2 received a regular diet and water ad libitum and fructose was administered as % 10 solution in drinking water. Group 3 received alpha-lipoic acid (100 mg/kg/day) i.p. for 5 weeks and Group 4 received coenzyme Q10 (10 mg/kg/day) i.p. for 5 weeks. For determination of plasma asymmetric dimethylarginine, glutathione and malondialdehyde levels, high-performance liquid chromatography system was used. Homeostatic model assessment as a measure of insulin resistance was calculated. Lipid profile measurements were determined using enzymatic assay on an Auto analyzer. The high fructose diet was significantly associated with an increase in levels of plasma LDL, VLDL and total cholesterol and decrease in level of HDL cholesterol. Plasma asymmetric dimethylarginine, malondialdehyde and glutathione levels were also increase in these rats. alpha-lipoic acid or coenzyme Q10 supplementation was found to have some positive effect on these parameters. These findings were also demonstrated by morphological observation of the aorta. We demonstrated that administration of alpha-lipoic acid and coenzyme Q10 notably suppresses oxidative and nitrative stress, hyperinsulinemia, insulin resistance developing in fructose fed rats, a model of metabolic syndrome (MS). These positive effects of alpha-lipoic acid or coenzyme Q10 can be attributed to its antioxidant activity.
C1 [Ozdogan, Serhat; Kaman, Dilara] Firat Univ, Firat Med Ctr, Firat Univ Med Hosp, Dept Biochem, TR-23100 Elazig, Turkey.
   [Simsek, Bengu Cobanoglu] Firat Univ, Firat Med Ctr, Dept Pathol, TR-23100 Elazig, Turkey.
C3 Firat University; Firat University
RP Özdogan, S (corresponding author), Firat Univ, Firat Med Ctr, Firat Univ Med Hosp, Dept Biochem, TR-23100 Elazig, Turkey.
RI kaman, dilara/V-9024-2018
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NR 68
TC 10
Z9 11
U1 0
U2 8
PU JOURNAL CLINICAL BIOCHEMISTRY & NUTRITION
PI KYOTO
PA KYOTO PREFECTURAL UNIV MED, GRAD SCH MEDICAL SCIENCE, DEPT MOLECULAR
   GASTROENTEROLOGY & HEPATOLOGY, KYOTO, 602-8566, JAPAN
SN 0912-0009
EI 1880-5086
J9 J CLIN BIOCHEM NUTR
JI J. Clin. Biochem. Nutr.
PD MAR 1
PY 2012
VL 50
IS 2
BP 145
EP 151
DI 10.3164/jcbn.11-47
PG 7
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 922DB
UT WOS:000302525900008
PM 22448096
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU dos Santos, DC
   de Oliveira, JG
   de Sousa, TL
   Ribeiro, CB
   Egea, MB
AF dos Santos, Daiane Costa
   de Oliveira Filho, Josemar Goncalves
   de Sousa, Tainara Leal
   Ribeiro, Carolina Barbosa
   Egea, Mariana Buranelo
TI Ameliorating effects of metabolic syndrome with the consumption of
   rich-bioactive compounds fruits from Brazilian Cerrado: a narrative
   review
SO CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
LA English
DT Review
DE Brazilian native fruits; diabetes; dyslipidemia; functional foods;
   obesity
ID EUGENIA-DYSENTERICA DC.; DIPTERYX-ALATA VOG.; ANACARDIUM-OCCIDENTALE L.;
   VITAMIN-C; CARYOCAR-BRASILIENSE; PHENOLIC-COMPOUNDS; CHLOROGENIC ACID;
   HIGH-FAT; OXIDATIVE STRESS; TROPICAL FRUITS
AB Evidence suggests that bioactive compounds present in fruits and vegetables, including carotenoids, polyphenols, and phytosterols, may have beneficial effects against the development of obesity and other diseases. The fruits of the Brazilian Cerrado are rich in biologically active compounds but are underexplored by the population being used only locally dietary consumption. The objective of this review is to direct attention to the bioactive compounds already elucidated for the fruits of "Cerrado" cashew (Anacadium othanianum Rizz.), baru almond (Dipteryx alata Vogel), cagaita (Eugenia dysenterica DC.), "Cerrado" pear (Eugenia klotzschiana Berg), mangaba (Hancornia speciosa), and pequi (Caryocar brasiliense Camb), demonstrating possible metabolic effects of the consumption of these fruits on the metabolic syndrome and its risk factors. Studies have shown that Cerrado native fruits have a high content of bioactive compounds such as phenolic compounds, which also demonstrate high antioxidant capacity and may be related to the protective effect in metabolic syndrome-related diseases by act as inhibitors in various processes in lipid metabolism and glucose transport. Although more scientific evidence is still needed, the consumption of native fruits from the Cerrado seems to be a promising strategy which -along with other strategies such as nutritional therapy- can ameliorate the effects of the metabolic syndrome.
C1 [dos Santos, Daiane Costa] Goias Fed Univ UFG, IPTSP UFG, Inst Trop Pathol & Publ Hlth, Goiania, Go, Brazil.
   [dos Santos, Daiane Costa; Ribeiro, Carolina Barbosa] Unibras Coll Rio Verde, Sch Nutr, Rio Verde, Go, Brazil.
   [de Oliveira Filho, Josemar Goncalves] Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, Araraquara, SP, Brazil.
   [de Sousa, Tainara Leal; Egea, Mariana Buranelo] Goias Fed Univ UFG, Dept Agron, Goiania, Go, Brazil.
   [Egea, Mariana Buranelo] Goiano Fed Inst Educ Sci & Technol, Rio Verde, Go, Brazil.
C3 Universidade Estadual Paulista; Instituto Federal de Goias (IFG)
RP Egea, MB (corresponding author), Goiano Fed Inst, Rio Verde, Go, Brazil.
EM mariana.egea@ifgoiano.edu.br
RI Egea, Mariana/B-1889-2014; Sousa, Tainara/ABA-9324-2020; de Oliveira
   Filho, Josemar/AAU-5158-2020
OI Goncalves de Oliveira Filho, Josemar/0000-0001-9755-7128
FU CNPq [426479/2016-5, 203394/2019-4, 308489/2020-9]; FAPEG; CAPES [001];
   IF Goiano
FX The authors acknowledge the financial support of CNPq (Processes no.
   426479/2016-5, no. 203394/2019-4, and no. 308489/2020-9), FAPEG, CAPES
   (001), and IF Goiano.
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NR 170
TC 18
Z9 18
U1 4
U2 42
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1040-8398
EI 1549-7852
J9 CRIT REV FOOD SCI
JI Crit. Rev. Food Sci. Nutr.
PD SEP 22
PY 2022
VL 62
IS 27
BP 7632
EP 7649
DI 10.1080/10408398.2021.1916430
EA APR 2021
PG 18
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA 4W4XB
UT WOS:000649594900001
PM 33977838
DA 2025-06-11
ER

PT J
AU Freeman, EW
AF Freeman, Ellen W.
TI Associations of depression with the transition to menopause
SO MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY
LA English
DT Article
DE Menopause; Perimenopause; Depression; Reproductive hormones; Estradiol;
   Hot flashes
ID MAJOR DEPRESSION; METABOLIC SYNDROME; NATURAL MENOPAUSE; WOMENS HEALTH;
   MIDLIFE WOMEN; SYMPTOMS; MOOD; HORMONES; RISK; SYMPTOMATOLOGY
AB Objectives: The aims of this study were to identify the risk of depression in the transition to menopause in women with and without a history of depression and to consider that the changing hormonal milieu is one of multiple risk factors for perimenopausal depression.
   Method: A review of epidemiologic studies of depressed mood in the menopausal transition since the State-of-Science Report of the National Institutes of Health in 2005 was conducted.
   Results: Recent longitudinal cohort studies indicate that the likelihood of depressed mood in the menopausal transition is approximately 30% to three times greater compared with that during premenopause. Women with a history of depression are nearly five times more likely to have a diagnosis of major depression in the menopausal transition, whereas women with no history of depression are two to four times more likely to report depressed mood compared with premenopausal women. In some studies, the changing hormonal milieu is significantly associated with depressive symptoms in the menopausal transition. Other risk factors for depressed mood in perimenopausal women include poor sleep, hot flashes, stressful or negative life events, employment status, age, and race.
   Conclusions: The findings support the concept that the menopausal transition is a "window of vulnerability" for some women and is framed by the changing hormonal milieu of ovarian aging.
C1 [Freeman, Ellen W.] Univ Penn, Dept Obstet Gynecol, Philadelphia, PA 19104 USA.
   [Freeman, Ellen W.] Univ Penn, Dept Psychiat, Philadelphia, PA 19104 USA.
C3 University of Pennsylvania; University of Pennsylvania
RP Freeman, EW (corresponding author), Univ Penn, Dept Obstet Gynecol, 3701 Market St,Suite 820 Mudd, Philadelphia, PA 19104 USA.
EM freemane@mail.med.upenn.edu
FU National Institutes of Health [RO1-AG-12745]; Clinical and Translational
   Research Center [RR024134]
FX Funding/support: Support was received through grants from the National
   Institutes of Health: RO1-AG-12745 (Dr. Freeman) and RR024134 (Clinical
   and Translational Research Center).
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NR 53
TC 191
Z9 210
U1 0
U2 26
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1072-3714
EI 1530-0374
J9 MENOPAUSE
JI Menopause-J. N. Am. Menopause Soc.
PD JUL-AUG
PY 2010
VL 17
IS 4
BP 823
EP 827
DI 10.1097/gme.0b013e3181db9f8b
PG 5
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA 624EO
UT WOS:000279799300027
PM 20531231
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Rinaldi, L
   Pafundi, PC
   Galiero, R
   Caturano, A
   Morone, MV
   Silvestri, C
   Giordano, M
   Salvatore, T
   Sasso, FC
AF Rinaldi, Luca
   Pafundi, Pia Clara
   Galiero, Raffaele
   Caturano, Alfredo
   Morone, Maria Vittoria
   Silvestri, Chiara
   Giordano, Mauro
   Salvatore, Teresa
   Sasso, Ferdinando Carlo
TI Mechanisms of Non-Alcoholic Fatty Liver Disease in the Metabolic
   Syndrome. A Narrative Review
SO ANTIOXIDANTS
LA English
DT Review
DE NAFLD; MAFLD; metabolic syndrome; insulin resistance; epigenetics;
   oxidative stress
ID CARDIOVASCULAR RISK-FACTORS; NECROSIS-FACTOR-ALPHA; MEDITERRANEAN DIET;
   INSULIN-RESISTANCE; GUT MICROBIOTA; PHYSICAL-ACTIVITY; OXIDATIVE STRESS;
   WEIGHT-LOSS; CHOLESTEROL-METABOLISM; HEPATOCYTE APOPTOSIS
AB Non-alcoholic fatty liver disease (NAFLD) and metabolic syndrome (MS) are two different entities sharing common clinical and physio-pathological features, with insulin resistance (IR) as the most relevant. Large evidence leads to consider it as a risk factor for cardiovascular disease, regardless of age, sex, smoking habit, cholesterolemia, and other elements of MS. Therapeutic strategies remain still unclear, but lifestyle modifications (diet, physical exercise, and weight loss) determine an improvement in IR, MS, and both clinical and histologic liver picture. NAFLD and IR are bidirectionally correlated and, consequently, the development of pre-diabetes and diabetes is the most direct consequence at the extrahepatic level. In turn, type 2 diabetes is a well-known risk factor for multiorgan damage, including an involvement of cardiovascular system, kidney and peripheral nervous system. The increased MS incidence worldwide, above all due to changes in diet and lifestyle, is associated with an equally significant increase in NAFLD, with a subsequent rise in both morbidity and mortality due to both metabolic, hepatic and cardiovascular diseases. Therefore, the slowdown in the increase of the "bad company" constituted by MS and NAFLD, with all the consequent direct and indirect costs, represents one of the main challenges for the National Health Systems.
C1 [Rinaldi, Luca; Pafundi, Pia Clara; Galiero, Raffaele; Caturano, Alfredo; Silvestri, Chiara; Giordano, Mauro; Sasso, Ferdinando Carlo] Univ Campania Luigi Vanvitelli, Dept Adv Med & Surg Sci, Piazza Luigi Miraglia 2, I-80138 Naples, Italy.
   [Morone, Maria Vittoria] Univ Campania Luigi Vanvitelli, Dept Expt Med, Microbiol Sect, Piazza Luigi Miraglia 2, I-80138 Naples, Italy.
   [Salvatore, Teresa] Univ Campania Luigi Vanvitelli, Dept Precis Med, Via De Crecchio 7, I-80138 Naples, Italy.
C3 Universita della Campania Vanvitelli; Universita della Campania
   Vanvitelli; Universita della Campania Vanvitelli
RP Sasso, FC (corresponding author), Univ Campania Luigi Vanvitelli, Dept Adv Med & Surg Sci, Piazza Luigi Miraglia 2, I-80138 Naples, Italy.
EM luca.rinaldi@unicampania.it; piaclara.pafundi@unicampania.it;
   raffaele.galiero@unicampania.it; alfredo.caturano@unicampania.it;
   mariavittoria.morone@unicampania.it; teresa.salvatore@unicampania.it;
   mauro.giordano@unicampania.it; teresa.salvatore@unicampania.it;
   ferdinando.sasso@unicampania.it
RI Galiero, Raffaele/KTP-8361-2024; Sasso, Ferdinando Carlo/AAE-5665-2019;
   Morone, Maria Vittoria/LOR-6766-2024; Caturano, Alfredo/AAA-4014-2022;
   PAFUNDI, PIA CLARA/GLN-5679-2022; Caturano, Alfredo/ACM-4169-2022
OI Morone, Maria Vittoria/0009-0000-0810-8460; PAFUNDI, PIA
   CLARA/0000-0002-0310-3529; Rinaldi, Luca/0000-0002-6541-3821; Caturano,
   Alfredo/0000-0001-7761-7533; Sasso, Ferdinando Carlo/0000-0002-9142-7848
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NR 228
TC 126
Z9 127
U1 8
U2 78
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD FEB
PY 2021
VL 10
IS 2
AR 270
DI 10.3390/antiox10020270
PG 25
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA QM9DT
UT WOS:000622074700001
PM 33578702
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU López-Acosta, O
   Ruiz-Ramírez, A
   Barrios-Maya, MA
   Alarcon-Aguilar, J
   Alarcon-Enos, J
   Acuña, CLC
   El-Hafidi, M
AF Lopez-Acosta, Ocarol
   Ruiz-Ramirez, Angelica
   Barrios-Maya, Miguel-Angel
   Alarcon-Aguilar, Javier
   Alarcon-Enos, Julio
   Acuna, Carlos L. Cespedes
   El-Hafidi, Mohammed
TI Lipotoxicity, glucotoxicity and some strategies to protect vascular
   smooth muscle cell against proliferative phenotype in metabolic syndrome
SO FOOD AND CHEMICAL TOXICOLOGY
LA English
DT Review
DE Cell phenotype; Cell proliferation; Free fatty acids; Metabolic
   syndrome; Oxidative stress; Smooth muscle cell
ID ARISTOTELIA-CHILENSIS ELAEOCARPACEAE; PRODUCTS-INDUCED PROLIFERATION;
   NADPH OXIDASE ACTIVATION; PANCREATIC BETA-CELLS; FREE FATTY-ACIDS;
   OXIDATIVE STRESS; NEOINTIMA FORMATION; INSULIN-RESISTANCE; SIGNALING
   PATHWAY; UP-REGULATION
AB Metabolic syndrome (MetS) is a risk factor for the development of cardiovascular disease (CVD) and atherosclerosis through a mechanism that involves vascular smooth muscle cell (VSMC) proliferation, lipotoxicity and glucotoxicity. Several molecules found to be increased in MetS, including free fatty acids, fatty acid binding protein 4, leptin, resistin, oxidized lipoprotein particles, and advanced glycation end products, influence VSMC proliferation. Most of these molecules act through their receptors on VSMCs by activating several signaling pathways associated with ROS generation in various cellular compartments. ROS from NADPH-oxidase and mitochondria have been found to promote VSMC proliferation and cell cycle progression. In addition, most of the natural or synthetic substances described in this review, including pharmaceuticals with hypoglycemic and hypolipidemic properties, attenuate VSMC proliferation by their simultaneous modulation of cell signaling and their scavenging property due to the presence of a phenolic ring in their structure. This review discusses recent data in the literature on the role that several MetS-related molecules and ROS play in the change from contractile to proliferative phenotype of VSMCs. Hence the importance of proposing an appropriate strategy to prevent uncontrolled VSMC proliferation using antioxidants, hypoglycemic and hypolipidemic agents.
C1 [Lopez-Acosta, Ocarol; Ruiz-Ramirez, Angelica; Barrios-Maya, Miguel-Angel; El-Hafidi, Mohammed] Inst Nacl Cardiol Ignacio Chavez, Dept Biomed Cardiovasc, Juan Badiano 1,Colonia Secc XVI, Mexico City 14080, DF, Mexico.
   [Alarcon-Aguilar, Javier] Univ Autonoma Metropolitana Unidad Iztapalapa, Dept Ciencias Biol & Salud, Lab Farmacol, Iztapalapa, Mexico.
   [Alarcon-Enos, Julio; Acuna, Carlos L. Cespedes] Univ Bio Bio, Fac Ciencias, Dept Ciencias Bas, Ave Andres Bello 720, Chillan, Chile.
C3 National Institute of Cardiology - Mexico; Universidad Autonoma
   Metropolitana - Mexico; Universidad del Bio-Bio
RP El-Hafidi, M (corresponding author), Inst Nacl Cardiol Ignacio Chavez, Dept Biomed Cardiovasc, Juan Badiano 1,Colonia Secc XVI, Mexico City 14080, DF, Mexico.; Acuña, CLC (corresponding author), Univ Bio Bio, Fac Ciencias, Dept Ciencias Bas, Ave Andres Bello 720, Chillan, Chile.
EM medelhafidi@yahoo.com
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NR 172
TC 10
Z9 11
U1 2
U2 15
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0278-6915
EI 1873-6351
J9 FOOD CHEM TOXICOL
JI Food Chem. Toxicol.
PD FEB
PY 2023
VL 172
AR 113546
DI 10.1016/j.fct.2022.113546
EA DEC 2022
PG 12
WC Food Science & Technology; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Toxicology
GA 7M1UW
UT WOS:000906441600001
PM 36513245
DA 2025-06-11
ER

PT J
AU Ebrahimian, Z
   Razavi, BM
   Shaegh, SAM
   Hosseinzadeh, H
AF Ebrahimian, Zeinab
   Razavi, Bibi Marjan
   Shaegh, Seyed Ali Mousavi
   Hosseinzadeh, Hossein
TI Effects of Portulaca oleracea L. (purslane) on the
   metabolic A review
SO IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
LA English
DT Review
DE Diabetes mellitus; Hypertension; Metabolic syndrome; Obesity; Portulaca
   oleracea; Purslane
ID AQUEOUS EXTRACT; OXIDATIVE STRESS; ANTIDIABETIC ACTIVITY;
   DIABETIC-NEPHROPATHY; MEDICINAL-PLANTS; POLYSACCHARIDE; CONSTITUENT;
   SAFFRON; SEEDS; PHARMACOLOGY
AB Metabolic syndrome (MetS) is defined as a disorder with multiple abnormalities, including obesity, high blood pressure, dyslipidemia, and high blood glucose. MetS is the best-known risk factor for type 2 diabetes mellitus (T2DM), cardiovascular disease (CVD), and obesity. With the globally increasing prevalence of MetS and its related abnormalities, attention to safe and effective prevention and treatment of this complex disorder has been increased. In particular, most treatments have been devoted to using natural agents that could provide more reliable and effective medicinal products with fewer side effects. Portulaca oleracea L. (purslane) is an herb whose therapeutic properties could be found in some ancient medical books. Purslane has shown analgesic, antispasmodic, skeletal muscle relaxant, bronchodilator, antiasthmatic, anti-inflammatory, antiseptic, diuretic, antibacterial, antipyretic, and wound-healing properties. In addition, purslane's hypoglycemic and hypolipidemic properties have been reported in different studies. The positive effects of this plant include reducing stress oxidative and inflammation along with the atherogenic index, improving insulin level and glucose uptake, decreasing lipid profiles, and ameliorating weight gain. These activities could reduce MetS complications. This review aims to provide a comprehensive overview of various in vitro, animal, and human studies regarding the effect of Portulaca oleracea on metabolic syndrome to better understand the underlying mechanisms of action for designing more effective treatments.
C1 [Ebrahimian, Zeinab; Razavi, Bibi Marjan; Hosseinzadeh, Hossein] Mashhad Univ Med Sci, Sch Pharm, Dept Pharmacodynam & Toxicol, Mashhad, Iran.
   [Razavi, Bibi Marjan] Mashhad Univ Med Sci, Targeted Drug Delivery Res Ctr, Sch Pharm, Dept Pharmacodynam & Toxicol, Mashhad, Iran.
   [Shaegh, Seyed Ali Mousavi] Mashhad Univ Med Sci, Ghaem Hosp, Clin Res Unit, Mashhad, Iran.
   [Shaegh, Seyed Ali Mousavi] Mashhad Univ Med Sci, Orthoped Res Ctr, Mashhad, Iran.
   [Shaegh, Seyed Ali Mousavi] Mashhad Univ Med Sci, Bu Ali Res Inst, Lab Microfluid & Med Microsyst, Mashhad, Iran.
   [Hosseinzadeh, Hossein] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Pharmaceut Res Ctr, Mashhad, Iran.
C3 Mashhad University of Medical Sciences; Mashhad University of Medical
   Sciences; Mashhad University of Medical Sciences; Mashhad University of
   Medical Sciences; Mashhad University of Medical Sciences; Mashhad
   University of Medical Sciences
RP Hosseinzadeh, H (corresponding author), Mashhad Univ Med Sci, Sch Pharm, Dept Pharmacodynam & Toxicol, Mashhad, Iran.; Hosseinzadeh, H (corresponding author), Mashhad Univ Med Sci, Pharmaceut Technol Inst, Pharmaceut Res Ctr, Mashhad, Iran.
EM hosseinzadehh@mums.ac
RI Razavi, Bibi/AAY-5636-2020; Hosseinzadeh, Hossein/F-3013-2010
FU Mashhad University of Medical Sciences, Iran
FX We thank the Vice-Chancellor of Research, Mashhad University of Medical
   Sciences, Iran for financial support.
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NR 112
TC 0
Z9 0
U1 1
U2 6
PU MASHHAD UNIV MED SCIENCES
PI MASHHAD
PA VICE-CHANCELLOR FOR RES CTR OFF IJBMS, DANESHGAH ST, PO BOX 9138813944 -
   445, MASHHAD, 00000, IRAN
SN 2008-3866
EI 2008-3874
J9 IRAN J BASIC MED SCI
JI Iran. J. Basic Med. Sci.
PD NOV
PY 2022
VL 25
IS 11
BP 1275
EP 1285
DI 10.22038/IJBMS.2022.63264.13967
PG 11
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA 9B5ZO
UT WOS:000934815500001
DA 2025-06-11
ER

PT J
AU Chaudhari, AS
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TI Genetically engineered Escherichia coli Nissle 1917 synbiotic
   counters fructose-induced metabolic syndrome and iron deficiency
SO APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
LA English
DT Article
DE E. coli Nissle 1917; Iron; Fructose; SCFA; Synbiotic
ID PYRROLOQUINOLINE QUINONE; OXIDATIVE STRESS; INSULIN-RESISTANCE;
   PLANTARUM 299V; DIETARY IRON; LIVER; ABSORPTION; DAMAGE;
   SUPPLEMENTATION; BIOAVAILABILITY
AB Consumption of fructose leads to metabolic syndrome, but it is also known to increase iron absorption. Present study investigates the effect of genetically modified Escherichia coli Nissle 1917 (EcN) synbiotic along with fructose on non-heme iron absorption. Charles foster rats weighing 150-200 g were fed with iron-deficient diet for 2 months. Probiotic treatment of EcN (pqq) and EcN (pqq-glf-mtlK) was given once per week, 10(9) cells after 2 months with fructose in drinking water. Iron levels, blood, and liver parameters for oxidative stress, hyperglycemia, and dyslipidemia were estimated. Transferrin-bound iron levels in the blood decreased significantly after 10 weeks of giving iron-deficient diet. Probiotic treatment of EcN (pqq-glf-mtlK) and fructose together led to the restoration of normal transferrin-bound iron levels and blood and hepatic antioxidant levels as compared to iron-deficient control group. The probiotic also led to the restoration of body weight along with levels of serum and hepatic lipid, blood glucose, and antioxidant in the blood and liver as compared to iron-deficient control group. Restoration of liver injury marker enzymes was also seen. Administration of EcN-producing PQQ and mannitol dehydrogenase enzyme together with fructose led to increase in the transferrin-bound iron levels in the blood and amelioration of consequences of metabolic syndrome caused due to fructose consumption.
C1 [Chaudhari, Archana Somabhai; Raghuvanshi, Ruma; Kumar, G. Naresh] Maharaja Sayajirao Univ Baroda, Dept Biochem, MMBL, Fac Sci, Vadodara 390002, Gujarat, India.
C3 Maharaja Sayajirao University Baroda
RP Kumar, GN (corresponding author), Maharaja Sayajirao Univ Baroda, Dept Biochem, MMBL, Fac Sci, Vadodara 390002, Gujarat, India.
EM gnaresh_k@yahoo.co.in
RI Gattupalli, Naresh/AAF-5987-2020
FU Department Of Biotechnology [DBT-JRF/2011-12/304]; Indian Council Of
   Medical Research [3/1/3/JRF-2012/HRD]
FX Archana Somabhai Chaudhari and Ruma Raghuvanshi are supported by Senior
   Research Fellowship of Department Of Biotechnology (DBT-JRF/2011-12/304)
   and Indian Council Of Medical Research (3/1/3/JRF-2012/HRD),
   respectively.
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NR 42
TC 12
Z9 15
U1 0
U2 17
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0175-7598
EI 1432-0614
J9 APPL MICROBIOL BIOT
JI Appl. Microbiol. Biotechnol.
PD JUN
PY 2017
VL 101
IS 11
BP 4713
EP 4723
DI 10.1007/s00253-017-8207-7
PG 11
WC Biotechnology & Applied Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology
GA EV8CP
UT WOS:000402008300031
PM 28283693
DA 2025-06-11
ER

PT J
AU Klöting, N
   Blüher, M
AF Kloeting, Nora
   Blueher, Matthias
TI Adipocyte dysfunction, inflammation and metabolic syndrome
SO REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
LA English
DT Review
DE Adipose tissue dysfunction; Obesity; Metabolic syndrome; Adipocyte;
   Adipokines; Inflammation
ID BODY-FAT DISTRIBUTION; ADIPOSE-TISSUE EXPANDABILITY; OBESITY-INDUCED
   INFLAMMATION; TYPE-2 DIABETES-MELLITUS; STRESS SIGNALING PATHWAY;
   INSULIN-RESISTANCE; MACROPHAGE INFILTRATION; CARDIOVASCULAR-DISEASE;
   NLRP3 INFLAMMASOME; SUBCUTANEOUS FAT
AB Obesity is frequently associated with chronic inflammation, metabolic and vascular alterations which predispose to the development of the Metabolic Syndrome (MetS). However, the individual obesity-related risk for the MetS is not determined by increased fat mass alone. Heterogeneity of body composition, fat distribution and adipose tissue (AT) function may underly the variable risk to develop metabolic and cardiovascular diseases associated with increased body fat mass. Importantly, an inability to increase AT mass by adipocyte hyperplasia may lead to adipocyte hypertrophy and could induce dysfunction of adipose tissue characterized by decreased insulin sensitivity, hypoxia, increased parameters of intracellular stress, increased autophagy and apoptosis and tissue inflammation. As a result, adipocytes and other AT cells release signals (e.g. adipokines, cells, metabolites) resulting in a proinflammatory, diabetogenic and atherogenic serum profile. These adverse signals may contribute to further AT inflammation and secondary organ damage in target tissues such as liver, brain, endothelium, vasculature, endocrine organs and skeletal muscle. Recently, a specific adipocyte volume threshold has been shown to predict the risk for obesity-associated type 2 diabetes.
   Most likely, impaired adipocyte function is caused by genetic, behavioural and environmental factors which are not entirely understood. Elucidating the mechanisms of adipocyte dysfunction may lead to the identification of novel treatment targets for obesity and the MetS.
C1 [Kloeting, Nora; Blueher, Matthias] Univ Leipzig, Dept Med, D-04103 Leipzig, Germany.
C3 Leipzig University
RP Blüher, M (corresponding author), Univ Leipzig, Dept Med, Liebigstr 20, D-04103 Leipzig, Germany.
EM bluma@medizin.uni-leipzig.de
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NR 94
TC 368
Z9 411
U1 5
U2 141
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1389-9155
EI 1573-2606
J9 REV ENDOCR METAB DIS
JI Rev. Endocr. Metab. Disord.
PD DEC
PY 2014
VL 15
IS 4
BP 277
EP 287
DI 10.1007/s11154-014-9301-0
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA AU0TW
UT WOS:000345338400004
PM 25344447
DA 2025-06-11
ER

PT J
AU Coêlho, CFF
   Souza, ILS
   Chagas, VT
   Ribeiro, NLX
   Pinto, BAS
   França, LM
   Paes, AMD
AF Coelho, Caio Fernando Ferreira
   Souza, Ivana Leticia Santos
   Chagas, Vinicyus Teles
   Ribeiro, Nathalee Liberal Xavier
   Pinto, Bruno Araujo Serra
   Franca, Lucas Martins
   Paes, Antonio Marcus de Andrade
TI Myricetin improves metabolic outcomes but not cognitive deficit
   associated to metabolic syndrome in male mice
SO FOOD & FUNCTION
LA English
DT Article
AB Myricetin is a flavonol highly prevalent in edible vegetables and fruits, with recognized hypoglycemic and anti-obesity effects, besides great antioxidant capacity. Thus, this study sought to investigate whether myricetin is able to improve metabolic and behavioral outcomes found in monosodium l-glutamate (MSG) obese mice, a model of metabolic syndrome characterized by early hyperinsulinemia associated to obesity, dyslipidemia, hepatic steatosis, anxiety and cognitive deficit. Newborn male mice received MSG (4 mg kg(-1) day(-1), s.c.) on alternate days during the first 10 days of life for obesity induction, while control pups received equimolar saline solution. From postnatal day 90 to 135, MSG mice were orally treated with myricetin (50 mg kg(-1) day(-1)) or distilled water, while control animals received vehicle. During the last week of treatment, all groups were submitted to behavioral tests: open field maze, elevated plus maze and Morris water maze. At the end of treatment, animals were euthanized for collection of liver, serum and adipose tissue fat pads. Myricetin treatment reduced the elevated serum levels of glucose and triglycerides, typically found in MSG mice, as well as restored peripheral insulin sensitivity and liver steatosis. Moreover, myricetin ameliorated the lack of thigmotaxis and exploratory behavior, but did not improve the cognitive deficit presented by MSG mice. Therefore, this study contributes to the pharmacological validation of myricetin as an affordable and healthy therapeutic adjuvant for the treatment of metabolic syndrome and most of its comorbidities.
C1 [Coelho, Caio Fernando Ferreira; Souza, Ivana Leticia Santos; Chagas, Vinicyus Teles; Ribeiro, Nathalee Liberal Xavier; Pinto, Bruno Araujo Serra; Franca, Lucas Martins; Paes, Antonio Marcus de Andrade] Univ Fed Maranhao, Hlth Sci Grad Program, Lab Expt Physiol, BR-65080805 Sao Luis, Maranhao, Brazil.
   [Chagas, Vinicyus Teles] Univ Fed Maranhao, Dept Morphol Sci, BR-65080805 Sao Luis, Maranhao, Brazil.
   [Pinto, Bruno Araujo Serra; Franca, Lucas Martins; Paes, Antonio Marcus de Andrade] Univ Fed Maranhao, Dept Physiol Sci, BR-65080805 Sao Luis, Maranhao, Brazil.
C3 Universidade Federal do Maranhao; Universidade Federal do Maranhao;
   Universidade Federal do Maranhao
RP Paes, AMD (corresponding author), Univ Fed Maranhao, Hlth Sci Grad Program, Lab Expt Physiol, BR-65080805 Sao Luis, Maranhao, Brazil.; Paes, AMD (corresponding author), Univ Fed Maranhao, Dept Physiol Sci, BR-65080805 Sao Luis, Maranhao, Brazil.
EM marcuspaes@ufma.br
RI França, Lucas/IAM-5986-2023; Paes, Antonio Marcus de Andrade/C-7174-2013
OI Paes, Antonio Marcus de Andrade/0000-0002-3803-9803
FU Fundacao de Amparo a Pesquisa e ao Desenvolvimento Cientifico,
   Tecnologico e Inovacao do Estado do Maranhao (FAPEMA)
   [APP-UNIVERSAL-01571/16]; Coordenacao de Aperfeicoamento de Pessoal de
   Nivel Superior (CAPES) [001]; Conselho Nacional de Desenvolvimento
   Cientifico e Tecnologico (CNPq); CAPES
FX The authors are especially grateful to the staff of Laboratory of
   Experimental Physiology for all technical support during the
   experimental procedures. This study was supported by the Fundacao de
   Amparo a Pesquisa e ao Desenvolvimento Cientifico, Tecnologico e
   Inovacao do Estado do Maranhao (FAPEMA; no APP-UNIVERSAL-01571/16) and
   Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES,
   Finance code 001). C. F. F. C. and I. L. S. S. and A. M. A. P. received
   fellowship from the Conselho Nacional de Desenvolvimento Cientifico e
   Tecnologico (CNPq). N. L. X. R. received fellowship from CAPES.
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NR 52
TC 7
Z9 8
U1 0
U2 10
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PD APR 21
PY 2021
VL 12
IS 8
BP 3586
EP 3596
DI 10.1039/d1fo00073j
EA MAR 2021
PG 11
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA RS9EI
UT WOS:000634844600001
PM 33900338
DA 2025-06-11
ER

PT J
AU Hirata, A
   Maeda, N
   Hiuge, A
   Hibuse, T
   Fujita, K
   Okada, T
   Kihara, S
   Funahashi, T
   Shimomura, I
AF Hirata, Ayumu
   Maeda, Norikazu
   Hiuge, Aki
   Hibuse, Toshiyuki
   Fujita, Koichi
   Okada, Takuya
   Kihara, Shinji
   Funahashi, Tohru
   Shimomura, Iichiro
TI Blockade of mineralocorticoid receptor reverses adipocyte dysfunction
   and insulin resistance in obese mice
SO CARDIOVASCULAR RESEARCH
LA English
DT Article
DE Adipose tissue; Inflammation; Insulin resistance; Oxidative stress;
   Mineralocorticoid receptor
ID SMOOTH-MUSCLE-CELLS; METABOLIC SYNDROME; ADIPOSE-TISSUE; ANGIOTENSIN-II;
   OXIDATIVE STRESS; VISCERAL OBESITY; NADPH OXIDASE; ALDOSTERONE;
   INFLAMMATION; ADIPONECTIN
AB In obesity, chronic low-grade inflammation and overproduction of reactive oxygen species (ROS) in fat contribute to the development of metabolic syndrome. Suppression of inflammation and ROS production in fat may attenuate the metabolic syndrome. Activation of mineralocorticoid receptor (MR) promotes inflammation in heart, kidney, and vasculature via ROS generation. However, the significance of MR in fat remains elusive. Here we investigated whether MR blockade attenuates obesity-related insulin resistance and improves adipocyte dysfunction.
   Obese ob/ob and db/db mice were treated with eplerenone, a MR antagonist, for 3 weeks. 3T3-L1 adipocytes were treated with aldosterone or H2O2, with and without eplerenone or MR-siRNA. High levels of MR mRNA were detected in adipose tissue of obese ob/ob and db/db mice. Eplerenone treatment significantly reduced insulin resistance, suppressed macrophage infiltration and ROS production in adipose tissues, and corrected the mRNA levels of obesity-related genes in obese mice. In 3T3-L1 adipocytes, aldosterone and H2O2 increased intracellular ROS levels and MR blockade inhibited such increases. H2O2 and aldosterone resulted in dysregulation of mRNAs of various genes related to ROS and cytokines, whereas MR blockade corrected such changes.
   MR blockade attenuates obesity-related insulin resistance partly through reduction of fat ROS production, inflammatory process, and induction of cytokines.
C1 [Hirata, Ayumu; Maeda, Norikazu; Hiuge, Aki; Hibuse, Toshiyuki; Fujita, Koichi; Okada, Takuya; Kihara, Shinji; Funahashi, Tohru; Shimomura, Iichiro] Osaka Univ, Grad Sch Med, Dept Metab Med, Suita, Osaka 5650871, Japan.
C3 The University of Osaka
RP Maeda, N (corresponding author), Osaka Univ, Grad Sch Med, Dept Metab Med, 2-2-B5 Yamada Oka, Suita, Osaka 5650871, Japan.
EM nmaeda@imed2.med.osaka-u.ac.jp
RI Kihara, Shinji/AAW-2015-2021; Maeda, Norikazu/LZI-4561-2025
FU Grant-in-Aid for Scientific Research [19390249]; Health and Labour
   Science Research Grants; Takeda Science Foundation; Takeda Medical
   Research Foundation; Cell Science Research Foundation; Yamanouchi
   Foundation for Research on Metabolic Disorders; Japan Heart Foundation
   Grant for Research on Arteriosclerosis Update; Japan Heart
   Foundation/Novartis; Japan Heart Foundation Research Grant; Japan
   Foundation of Cardiovascular Research; Grants-in-Aid for Scientific
   Research [19390249] Funding Source: KAKEN
FX This work was supported in part by a Grant-in-Aid for Scientific
   Research (B) no. 19390249 (to T. F.), Health and Labour Science Research
   Grants (to T. F.), Takeda Science Foundation (to T. F.), Takeda Medical
   Research Foundation (to T. F.), The Cell Science Research Foundation (to
   N. M.), Yamanouchi Foundation for Research on Metabolic Disorders (to N.
   M.), Japan Heart Foundation Grant for Research on Arteriosclerosis
   Update (to N. M.), Japan Heart Foundation/Novartis Grant for Research
   Award on Molecular and Cellular Cardiology (to N. M.), Japan Heart
   Foundation Research Grant (to N. M.), and Japan Foundation of
   Cardiovascular Research (to N. M.).
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NR 37
TC 187
Z9 201
U1 1
U2 4
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0008-6363
EI 1755-3245
J9 CARDIOVASC RES
JI Cardiovasc. Res.
PD OCT 1
PY 2009
VL 84
IS 1
BP 164
EP 172
DI 10.1093/cvr/cvp191
PG 9
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 493KN
UT WOS:000269735600022
PM 19505930
OA Bronze
DA 2025-06-11
ER

PT J
AU Mlakar, P
   Salobir, B
   Cobo, N
   Jug, B
   Tercelj, M
   Sabovic, M
AF Mlakar, Polona
   Salobir, Barbara
   Cobo, Nusret
   Jug, Borut
   Tercelj, Marjeta
   Sabovic, Miso
TI The Effect of Short-Term Cardiac Rehabilitation After Acute Myocardial
   Infarction on High-Sensitivity C-Reactive Protein
SO METABOLIC SYNDROME AND RELATED DISORDERS
LA English
DT Article
ID GENOME-WIDE ASSOCIATION; PHYSICAL-ACTIVITY; CARDIOVASCULAR-DISEASE;
   INFLAMMATORY MARKERS; OXIDATIVE STRESS; RISK; ATHEROSCLEROSIS;
   MORTALITY; EXERCISE; SMOKERS
AB Background: High-sensitivity C-reactive protein (hsCRP) is an important biomarker of risk for coronary heart disease morbidity and mortality. We investigated the influence of short-term cardiac rehabilitation (CR) after acute myocardial infarction (AMI) on values of hsCRP and classical risk factors, including metabolic syndrome.
   Methods: hsCRP and classical risk factors were measured before and after completed 2-week CR program in 30 men after AMI. The comparison group comprised 30 age-balanced healthy men, with no risk factors for coronary heart disease.
   Results: As expected, in comparison to healthy individuals, patients had higher values of hsCRP; furthermore, smokers had significantly higher hsCRP values than nonsmokers. Patients had more expressed markers of metabolic syndrome and due to pharmacological therapy lower blood pressure, total cholesterol and low-density lipoprotein cholesterol (LDL-C). After CR was completed, a significant drop in hsCRP (P=0.006) and improvement of metabolic syndrome parameters (lower body mass index, blood pressure, LDL-C, triglycerides) was observed in nonsmokers, whereas no such changes occurred in smokers.
   Conclusions: Our study revealed that hsCRP and metabolic syndrome parameters can be substantially reduced by a 2-week CR program; however, this effect is present only in nonsmokers. Thus, all patients entering the CR program after AMI should be advised to quit smoking before entering the program to achieve optimal benefits.
C1 [Mlakar, Polona; Salobir, Barbara; Tercelj, Marjeta] Univ Med Ctr Ljubljana, Clin Pulm Dis & Allergy, Ljubljana 1000, Slovenia.
   [Mlakar, Polona; Jug, Borut; Sabovic, Miso] Univ Med Ctr Ljubljana, Clin Prevent Cardiol & Vasc Med, Ljubljana 1000, Slovenia.
   [Cobo, Nusret] Hlth Resort Radenci, Radenci, Slovenia.
C3 University Medical Centre Ljubljana; University Medical Centre Ljubljana
RP Mlakar, P (corresponding author), Univ Med Ctr Ljubljana, Clin Pulm Dis & Allergy, Zaloska 7, Ljubljana 1000, Slovenia.
EM polona.mlakar@telemach.net
RI Jug, Borut/AAY-6226-2020
OI Jug, Borut/0000-0001-6015-2127
FU Slovenian project [CRP V4-0513]
FX The study was completely supported by Slovenian project called Target
   Research Programmes until 2013 (grant no. CRP V4-0513). Our special
   thanks go to head nurse Marinka Secnik, nutritionist Janja Strasek, and
   all of the medical and nurse staff from Terme Krka Smarjeske Toplice
   Health resort, Slovenia, who helped with the clinical part of the study
   and to Prof. Marija Prezelj, chief of laboratory, and laboratory
   technicians Marjana Prah and Vera Troha at the Clinical Institute of
   Clinical Chemistry and Biochemistry, University Medical Center
   Ljubljana, Slovenia, for the excellent performance of laboratory
   investigations.
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NR 28
TC 4
Z9 5
U1 0
U2 6
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-4196
EI 1557-8518
J9 METAB SYNDR RELAT D
JI Metab. Syndr. Relat. Disord.
PD MAR 1
PY 2014
VL 12
IS 2
BP 149
EP 155
DI 10.1089/met.2013.0038
PG 7
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA AB0CP
UT WOS:000331459700010
PM 24266733
DA 2025-06-11
ER

PT J
AU Zaeemzadeh, N
   Sadatmahalleh, SJ
   Ziaei, S
   Kazemnejad, A
   Movahedinejad, M
   Mottaghi, A
   Mohamadzadeh, N
AF Zaeemzadeh, Narges
   Sadatmahalleh, Shahideh Jahanian
   Ziaei, Saeideh
   Kazemnejad, Anoshirvan
   Movahedinejad, Maryam
   Mottaghi, Azadeh
   Mohamadzadeh, Neda
TI Comparison of dietary micronutrient intake in PCOS patients with and
   without metabolic syndrome
SO JOURNAL OF OVARIAN RESEARCH
LA English
DT Article
DE Polycystic ovarian syndrome (PCOS); Metabolic syndrome (MetS);
   Antioxidants; Dietary intake; Micronutrients
ID POLYCYSTIC-OVARY-SYNDROME; INSULIN-RESISTANCE; OXIDATIVE STRESS;
   CHROMIUM SUPPLEMENTATION; SELENIUM LEVELS; RISK-FACTORS; ZINC
   SUPPLEMENTATION; WOMEN; ANTIOXIDANT; ASSOCIATION
AB Background: Polycystic ovarian syndrome (PCOS) is the most common endocrine disorder in reproductive-age women. It is one of the risk factors of metabolic syndrome (MetS). These two syndromes have an inflammatory etiologic foundation along with oxidative stress. The present study aimed to compare the dietary intake of antioxidant micronutrients in PCOS women with and without MetS.
   Materials and methods: Overall, 42 participants eligible for this nested case control study were selected by the convenience sampling method. The case group included 14 PCOS patients with MetS and the control group included 28 PCOS patients without MetS. The dietary intake assessment of selenium, chromium, zinc, carotenoids, vitamin D and vitamin E was carried out by a 147-item Food Frequency Questionnaire (FFQ). PCOS and MetS were diagnosed using the Rotterdam criteria and NCEP ATP III, respectively. Statistical analysis was performed using SPSS16 software, T-test and Mann Whitney. Significant P-value was considered 0.05.
   Results: Dietary intake of antioxidant micronutrients (selenium, zinc, chromium, carotenoids and vitamin E) was significantly lower in the PCOS women with MetS than in the control group (P < 0.05).
   Conclusion: Since the PCOS patients without MetS had more intake of the aforementioned micronutrients than those with MetS, it is assumed that the dietary intake of these nutrients could probably have a protective effect on MetS.
C1 [Zaeemzadeh, Narges; Sadatmahalleh, Shahideh Jahanian; Ziaei, Saeideh; Movahedinejad, Maryam; Mohamadzadeh, Neda] Tarbiat Modares Univ, Fac Med Sci, Dept Reprod Hlth & Midwifery, Tehran, Iran.
   [Kazemnejad, Anoshirvan] Tarbiat Modares Univ, Fac Med Sci, Dept Biostat, Tehran, Iran.
   [Mottaghi, Azadeh] Iran Univ Med Sci, Res Ctr Prevent Cardiovasc Dis, Inst Endocrinol & Metab, Tehran, Iran.
C3 Tarbiat Modares University; Tarbiat Modares University; Iran University
   of Medical Sciences
RP Ziaei, S (corresponding author), Tarbiat Modares Univ, Fac Med Sci, Dept Reprod Hlth & Midwifery, Tehran, Iran.
EM ziaei_sa@modraes.ac.ir
RI Jahanian, Shahideh/AAM-7845-2020; Mottaghi, Azadeh/AAP-6399-2021
OI Kazemnejad, Anoshirvan/0000-0002-0143-9635
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NR 60
TC 8
Z9 8
U1 3
U2 12
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1757-2215
J9 J OVARIAN RES
JI J. Ovarian Res.
PD JAN 9
PY 2021
VL 14
IS 1
AR 10
DI 10.1186/s13048-020-00746-0
PG 9
WC Reproductive Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Reproductive Biology
GA PU3GJ
UT WOS:000609192000001
PM 33422126
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Yamaoka, M
   Maeda, N
   Nakamura, S
   Kashine, S
   Nakagawa, Y
   Hiuge-Shimizu, A
   Okita, K
   Imagawa, A
   Matsuzawa, Y
   Matsubara, K
   Funahashi, T
   Shimomura, I
AF Yamaoka, Masaya
   Maeda, Norikazu
   Nakamura, Seiji
   Kashine, Susumu
   Nakagawa, Yasuhiko
   Hiuge-Shimizu, Aki
   Okita, Kohei
   Imagawa, Akihisa
   Matsuzawa, Yuji
   Matsubara, Ken-ichi
   Funahashi, Tohru
   Shimomura, Iichiro
TI A Pilot Investigation of Visceral Fat Adiposity and Gene Expression
   Profile in Peripheral Blood Cells
SO PLOS ONE
LA English
DT Article
ID METABOLIC SYNDROME; T-CELLS; CIRCADIAN-RHYTHMS; CLOCK GENES; OBESITY;
   ADIPOCYTOKINES; ACCUMULATION; INFLAMMATION; STRESS
AB Evidence suggests that visceral fat accumulation plays a central role in the development of metabolic syndrome. Excess visceral fat causes local chronic low-grade inflammation and dysregulation of adipocytokines, which contribute in the pathogenesis of the metabolic syndrome. These changes may affect the gene expression in peripheral blood cells. This study for the first time examined the association between visceral fat adiposity and gene expression profile in peripheral blood cells. The gene expression profile was analyzed in peripheral blood cells from 28 obese subjects by microarray analysis. Reverse transcription-polymerase chain reaction (RT-PCR) was performed using peripheral blood cells from 57 obese subjects. Obesity was defined as body mass index (BMI) greater than 25 kg/m(2) according to the Japanese criteria, and the estimated visceral fat area (eVFA) was measured by abdominal bioelectrical impedance. Analysis of gene expression profile was carried out with Agilent whole human genome 4644 K oligo-DNA microarray. The expression of several genes related to circadian rhythm, inflammation, and oxidative stress correlated significantly with visceral fat accumulation. Period homolog 1 (PER1) mRNA level in blood cells correlated negatively with visceral fat adiposity. Stepwise multiple regression analysis identified eVFA as a significant determinant of PER1 expression. In conclusion, visceral fat adiposity correlated with the expression of genes related to circadian rhythm and inflammation in peripheral blood cells.
C1 [Yamaoka, Masaya; Maeda, Norikazu; Kashine, Susumu; Nakagawa, Yasuhiko; Hiuge-Shimizu, Aki; Okita, Kohei; Imagawa, Akihisa; Funahashi, Tohru; Shimomura, Iichiro] Osaka Univ, Grad Sch Med, Dept Metab Med, Suita, Osaka, Japan.
   [Nakamura, Seiji; Matsubara, Ken-ichi] DNA Chip Res Inc, Yokohama, Kanagawa, Japan.
   [Matsuzawa, Yuji] Sumitomo Hosp, Osaka, Japan.
C3 The University of Osaka; DNA Chip Research Inc.; Sumitomo Hospital
RP Maeda, N (corresponding author), Osaka Univ, Grad Sch Med, Dept Metab Med, Suita, Osaka, Japan.
EM norikazu_maeda@endmet.med.osaka-u.ac.jp
RI Maeda, Norikazu/LZI-4561-2025
FU [22590979];  [22126008]; Grants-in-Aid for Scientific Research
   [22590979] Funding Source: KAKEN
FX This work was supported in part by Grants-in-Aid for Scientific Research
   (C) no. 22590979 (to N.M.) and Scientific Research on Innovative Areas
   no. 22126008 (to T.F.). The funders had no role in study design, data
   collection and analysis, decision to publish, or preparation of the
   manuscript.
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NR 25
TC 32
Z9 37
U1 0
U2 9
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD OCT 16
PY 2012
VL 7
IS 10
AR e47377
DI 10.1371/journal.pone.0047377
PG 7
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 024UX
UT WOS:000310135800042
PM 23091619
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Bacchetti, T
   Ferretti, G
   Carbone, F
   Ministrini, S
   Montecucco, F
   Jamialahmadi, T
   Sahebkar, A
AF Bacchetti, Tiziana
   Ferretti, Gianna
   Carbone, Federico
   Ministrini, Stefano
   Montecucco, Fabrizio
   Jamialahmadi, Tannaz
   Sahebkar, Amirhossein
TI Dysfunctional High-density Lipoprotein: The Role of Myeloperoxidase and
   Paraoxonase-1
SO CURRENT MEDICINAL CHEMISTRY
LA English
DT Review
DE High-density lipoprotein; Myeloperoxidase; Paraoxonase; Atherosclerosis;
   metabolic syndrome; HDL activity
ID APOLIPOPROTEIN-A-I; CORONARY-ARTERY-DISEASE; CHOLESTEROL EFFLUX;
   METHIONINE OXIDATION; OVERWEIGHT PATIENTS; MEDIATED OXIDATION;
   INSULIN-RESISTANCE; DIABETIC-PATIENTS; HDL; IMPAIRS
AB Low circulating high-density lipoproteins (HDL) are not only defining criteria for metabolic syndrome, but are more generally associated with atherosclerotic cardiovascular disease (ASCVD) and other chronic diseases. Oxidative stress, a hallmark of cardio-metabolic disease, further influences HDL activity by suppressing their function. Especially the leukocyte-derived enzyme myeloperoxidase (MPO) has recently attracted great interest as it catalyzes the formation of oxidizing reactive species that modify the structure and function of HDL, ultimately increasing cardiovascular risk. Contrariwise, paraoxonase-1 (PON1) is an HDL-associated enzyme that protects HDL from lipid oxidation and then acts as a protective factor against ASCVD. It is noteworthy that recent studies have demonstrated how MPO, PON1 and HDL form a functional complex in which PON1 partially inhibits the MPO activity, while MPO in turn partially inactivates PON1.In line with that, a high MPO/PON1 ratio characterizes patients with ASCVD and metabolic syndrome and has been suggested as a potential marker of dysfunctional HDL as well as a predictor of ASCVD. In this review, we summarize the evidence on the interactions between MPO and PON1 with regard to their structure, function and interaction with HDL activity. We also provide an overview of in vitro and experimental animal models, finally focusing on clinical evidence from a cohort of patients with ASCVD and metabolic syndrome.
C1 [Bacchetti, Tiziana] Polytech Univ Marche, Dept Life & Environm Sci DiSVA, Ancona, Italy.
   [Ferretti, Gianna] Polytech Univ Marche, Dept Clin Sci & Odontostomatol, Ancona, Italy.
   [Carbone, Federico; Montecucco, Fabrizio] Univ Genoa, Clin Internal Med 1, Dept Internal Med, 6 Viale Benedetto XV, I-16132 Genoa, Italy.
   [Carbone, Federico; Montecucco, Fabrizio] IRCCS Osped Policlin San Martino Genoa, Italian Cardiovasc Network, 10 Largo Benzi, I-16132 Genoa, Italy.
   [Ministrini, Stefano] Univ Perugia, Internal Med Dept, Santa Maria Misericordia Hosp, Piazzale Menghini, I-06132 Perugia, Italy.
   [Montecucco, Fabrizio] Univ Genoa, Ctr Excellence Biomed Res CEBR, 6 Viale Benedetto XV, I-16132 Genoa, Italy.
   [Jamialahmadi, Tannaz] Islamic Azad Univ, Dept Food Sci & Technol, Quchan Branch, Quchan, Iran.
   [Jamialahmadi, Tannaz] Mashhad Univ Med Sci, Fac Med, Dept Nutr, Mashhad, Razavi Khorasan, Iran.
   [Sahebkar, Amirhossein] FDA, Halal Res Ctr IRI, Tehran, Iran.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Neurogen Inflammat Res Ctr, Mashhad, Razavi Khorasan, Iran.
   [Sahebkar, Amirhossein] Mashhad Univ Med Sci, Sch Pharm, Mashhad, Razavi Khorasan, Iran.
   [Sahebkar, Amirhossein] Polish Mothers Mem Hosp, Res Inst PMMHRI, Lodz, Poland.
C3 Marche Polytechnic University; Marche Polytechnic University; University
   of Genoa; University of Genoa; IRCCS AOU San Martino IST; University of
   Perugia; Hospital Santa Maria della Misericordia; University of Genoa;
   Islamic Azad University; Mashhad University of Medical Sciences; Mashhad
   University of Medical Sciences; Mashhad University of Medical Sciences;
   Polish Mother's Memorial Hospital - Research Institute
RP Ferretti, G (corresponding author), Polytech Univ Marche, Dept Clin Sci & Odontostomatol, Ancona, Italy.; Sahebkar, A (corresponding author), FDA, Halal Res Ctr IRI, Tehran, Iran.; Sahebkar, A (corresponding author), Mashhad Univ Med Sci, Neurogen Inflammat Res Ctr, Mashhad, Razavi Khorasan, Iran.; Sahebkar, A (corresponding author), Mashhad Univ Med Sci, Sch Pharm, Mashhad, Razavi Khorasan, Iran.; Sahebkar, A (corresponding author), Polish Mothers Mem Hosp, Res Inst PMMHRI, Lodz, Poland.
EM giannaferretti@gmail.com; sahebkara@mums.ac.ir
RI Ministrini, Stefano/ABO-8757-2022; Sahebkar, Amirhossein/B-5124-2018;
   Carbone, Federico/G-3650-2013; Montecucco, Fabrizio/K-8543-2016
OI Ferretti, Gianna/0000-0001-7879-7935; Carbone,
   Federico/0000-0003-2957-4078; Montecucco, Fabrizio/0000-0003-0823-8729;
   Jami, Tannaz/0000-0001-9521-3153; Bacchetti,
   Tiziana/0000-0003-3346-9588; Ministrini, Stefano/0000-0003-4358-6411
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U1 0
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PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 0929-8673
EI 1875-533X
J9 CURR MED CHEM
JI Curr. Med. Chem.
PY 2021
VL 28
IS 14
BP 2842
EP 2850
DI 10.2174/0929867327999200716112353
PG 9
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Pharmacology &
   Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
GA TI4BW
UT WOS:000672743100009
PM 32674726
DA 2025-06-11
ER

PT J
AU Rarinca, V
   Vasile, A
   Visternicu, M
   Burlui, V
   Halitchi, G
   Ciobica, A
   Singeap, AM
   Dobrin, R
   Burlui, E
   Maftei, L
   Trifan, A
AF Rarinca, Viorica
   Vasile, Amalia
   Visternicu, Malina
   Burlui, Vasile
   Halitchi, Gabriela
   Ciobica, Alin
   Singeap, Ana-Maria
   Dobrin, Romeo
   Burlui, Ecaterina
   Maftei, Lucian
   Trifan, Anca
TI Relevance of diet in schizophrenia: a review focusing on prenatal
   nutritional deficiency, obesity, oxidative stress and inflammation
SO FRONTIERS IN NUTRITION
LA English
DT Article
DE schizophrenia; diet; nutrients; obesity; oxidative stress; inflammation;
   antioxidants; prenatal nutritional deficiency justified
ID VITAMIN-D DEFICIENCY; METABOLIC SYNDROME; SUPEROXIDE-DISMUTASE;
   1ST-EPISODE PSYCHOSIS; ABDOMINAL OBESITY; BRAIN-DEVELOPMENT; KETOGENIC
   DIET; WEIGHT-GAIN; LIFE-STYLE; RISK
AB Background/Objectives: Schizophrenia is a complex mental disorder influenced by genetic and environmental factors, including dietary habits. Oxidative stress and inflammation play a crucial role in the pathophysiology of schizophrenia. Emerging research suggests that diet may affect schizophrenia through different biological mechanisms beyond oxidative stress and inflammation. In particular, epigenetic changes may alter the expression of genes related to neurodevelopment and neurotransmitter systems, while neuroplasticity plays a crucial role in brain adaptation and resilience to psychiatric disorders. Methods: The literature search included the main available databases (Science Direct, PubMed and Google Scholar), considering the English language, and our screening was performed based on several words such as "schizophrenia", "diet", "nutrients", "obesity", "oxidative stress", "inflammation", "antioxidants" and "prenatal nutritional deficiency". The review focused specifically on studies examining the relevance of diet in schizophrenia, as well as prenatal nutritional deficiency, obesity, oxidative stress, and inflammation associated with this disorder. Results: Following a review of the literature, it was found that nutritional deficiencies, including lack of omega-3 fatty acids, vitamins D, and B, during the prenatal and postnatal periods can have a negative impact on neurodevelopment and increase the risk of schizophrenia. Patients with schizophrenia have imbalances in antioxidant enzymes, such as glutathione peroxidase (GPx), superoxide dismutase (SOD), catalase (CAT), and reduced levels of antioxidants (vitamin E, vitamin C). These biochemical changes lead to an increase in markers of oxidative stress, including malondialdehyde (MDA). In addition, cytokine-mediated inflammation, microglial activation, and intestinal dysbiosis are associated with the onset of schizophrenia and the severity of schizophrenia symptoms. Currently, there is no universally accepted dietary regimen for control. However, various diets and nutritional methods are being researched and applied to alleviate the symptoms of schizophrenia and improve the overall health of patients, including the Mediterranean diet, the ketogenic diet, the gluten-free diet, and the DASH (Dietary Approaches to Stop Hypertension) diet. Conclusion: A healthy diet, rich in anti-inflammatory nutrients and antioxidants, may help manage schizophrenia by reducing oxidative stress, preventing complications, and improving quality of life. Omega-3 fatty acids, vitamin D, and B vitamins are particularly important for brain development and function. In this review, we aim to analyze the literature on the influence of diet on schizophrenia, focusing on the role of prenatal nutritional deficiencies, obesity, oxidative stress, and inflammation.
C1 [Rarinca, Viorica] Alexandru Ioan Cuza Univ, Fac Geog & Geol, Doctoral Sch Geosci, Iasi, Romania.
   [Rarinca, Viorica; Visternicu, Malina] Alexandru Ioan Cuza Univ, Fac Biol, Doctoral Sch Biol, Iasi, Romania.
   [Rarinca, Viorica; Visternicu, Malina; Burlui, Vasile; Halitchi, Gabriela; Ciobica, Alin; Burlui, Ecaterina] Apollonia Univ, Preclin Dept, Iasi, Romania.
   [Vasile, Amalia; Ciobica, Alin] Alexandru Ioan Cuza Univ, Fac Biol, Iasi, Romania.
   [Ciobica, Alin] Grigore T Popa Univ Med & Pharm Iasi, CENEMED Platform Interdisciplinary Res, Iasi, Romania.
   [Ciobica, Alin] Romanian Acad Scientists, Bucharest, Romania.
   [Singeap, Ana-Maria; Trifan, Anca] Grigore T Popa Univ Med & Pharm, Rheumatol Dept, Iasi, Romania.
   [Singeap, Ana-Maria; Trifan, Anca] Sf Spiridon, Inst Gastroenterol & Hepatol, Iasi, Romania.
   [Dobrin, Romeo] Socola Psychiat Inst, Iasi, Romania.
   [Dobrin, Romeo] Grigore T Popa Univ Med & Pharm, Iasi, Romania.
   [Maftei, Lucian] SC MAKEUP SHOP SRL, Cosmet Prod Dev Dept, Iasi, Romania.
C3 Alexandru Ioan Cuza University; Alexandru Ioan Cuza University;
   Apollonia University; Alexandru Ioan Cuza University; Grigore T Popa
   University of Medicine & Pharmacy; Academy of Romanian Scientists
   (AOSR); Grigore T Popa University of Medicine & Pharmacy; Grigore T Popa
   University of Medicine & Pharmacy
RP Halitchi, G (corresponding author), Apollonia Univ, Preclin Dept, Iasi, Romania.; Singeap, AM (corresponding author), Grigore T Popa Univ Med & Pharm, Rheumatol Dept, Iasi, Romania.; Singeap, AM (corresponding author), Sf Spiridon, Inst Gastroenterol & Hepatol, Iasi, Romania.
EM gabriella_halitchi@yahoo.com; anamaria.singeap@yahoo.com
RI Trifan, Anca/MTF-7993-2025; dobrin, romeo/AAD-9060-2022; Ciobica,
   Alin/B-6073-2012; Rarinca, Viorica/AER-4082-2022
OI Rarinca, Viorica/0000-0003-0256-8911; Trifan, Anca/0000-0001-9144-5520
FU Operational Program for Competitiveness 2014- 2020, Axis 1, under
   POC/448/1/1 Research infrastructure projects for public R&D
   institutions/universities, project "Multidisciplinary platform for
   medical research-development in N-E region, CENEMED" [127606,
   POC/448/1/1]
FX The author(s) declare that financial support was received for the
   research, authorship, and/or publication of this article. This article
   is funded through the Operational Program for Competitiveness 2014-2020,
   Axis 1, under POC/448/1/1 Research infrastructure projects for public
   R&D institutions/universities, project "Multidisciplinary platform for
   medical research-development in N-E region, CENEMED," grant agreement
   no. 127606.
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NR 231
TC 0
Z9 0
U1 10
U2 10
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2296-861X
J9 FRONT NUTR
JI Front. Nutr.
PD DEC 13
PY 2024
VL 11
AR 1497569
DI 10.3389/fnut.2024.1497569
PG 21
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA Q5V9Z
UT WOS:001385365300001
PM 39734678
OA gold
DA 2025-06-11
ER

PT J
AU Cui, F
   Shi, M
   Hu, HF
   Tian, YM
   Zhou, CM
   Mi, HC
   Gu, S
   Guo, Z
   Zhang, XJ
   Zhang, Y
AF Cui, Fang
   Shi, Min
   Hu, Hao-Fei
   Tian, Yan-Ming
   Zhou, Chen-Ming
   Mi, Hai-Chao
   Gu, Shuo
   Guo, Zan
   Zhang, Xiang-Jian
   Zhang, Yi
TI Adenosine Mono-Phosphate-Activated Protein Kinase-Mammalian Target of
   Rapamycin Signaling Participates in the Protective Effect of Chronic
   Intermittent Hypobaric Hypoxia on Vascular Endothelium of Metabolic
   Syndrome Rats
SO CHINESE JOURNAL OF PHYSIOLOGY
LA English
DT Article
DE AMPK-mTOR signaling pathway; autophagy; chronic intermittent hypobaric
   hypoxia; endothelium dependent relaxation; metabolic syndrome
ID NITRIC-OXIDE; AUTOPHAGY ENHANCER; CELL-SURVIVAL; DYSFUNCTION;
   INFLAMMATION; PATHWAY; STRESS; AMPK; INHIBITION; INCREASES
AB Our previous study demonstrated that chronic intermittent hypobaric hypoxia (CIHH) protects vascular endothelium function through ameliorating autophagy in mesenteric arteries of metabolic syndrome (MS) rats. This study aimed to investigate the role of adenosine mono-phosphate-activated protein kinase-mammalian target of rapamycin (AMPK-mTOR) signaling in CIHH effect. Six-week-old male Sprague-Dawley rats were divided into control (CON), MS model, CIHH treatment (CIHH), and MS + CIHH groups. Serum pro-inflammatory cytokines were measured. The endothelium dependent relaxation (EDR), endothelial ultrastructure and autophagosomes were observed in mesenteric arteries. The expression of phosphor (p)-AMPK alpha, p-mTOR, autophagy-related and endoplasmic reticulum stress-related proteins, p-endothelial nitric oxide synthase, and cathepsin D were assayed. In MS rats, pro-inflammatory cytokines were increased, EDR was attenuated, and endothelial integrity was impaired. In addition, the expression level of p-AMPK alpha and cathepsin D was down-regulated, but the level of p-mTOR was up-regulated. While in MS + CIHH rats, all aforementioned abnormalities were ameliorated, and the beneficial effect of CIHH was cancelled by AMPK alpha inhibitor. In conclusion, AMPK-mTOR signaling pathway participates in the protection of CIHH on vascular endothelium of MS rats.
C1 [Cui, Fang; Tian, Yan-Ming; Gu, Shuo; Guo, Zan; Zhang, Yi] Hebei Med Univ, Dept Physiol, Shijiazhuang 050017, Hebei, Peoples R China.
   [Cui, Fang; Zhou, Chen-Ming] Hebei Med Univ, Dept Electron Microscopy Lab Ctr, Shijiazhuang, Hebei, Peoples R China.
   [Shi, Min; Hu, Hao-Fei; Mi, Hai-Chao] Hebei Med Univ, Dept Clin Lab, Hosp 2, Shijiazhuang, Hebei, Peoples R China.
   [Zhang, Xiang-Jian; Zhang, Yi] Hebei Collaborat Innovat Ctr Cardiocerebrovasc Di, Shijiazhuang, Hebei, Peoples R China.
C3 Hebei Medical University; Hebei Medical University; Hebei Medical
   University
RP Zhang, Y (corresponding author), Hebei Med Univ, Dept Physiol, Shijiazhuang 050017, Hebei, Peoples R China.
EM zhyhenryphy@163.com
RI Zhang, Yipu/GXV-8541-2022
OI Shi, Min/0009-0004-8316-447X
FU National Basic Research Development Program of China [2012CB518200];
   National Natural Science Foundation of China [31671184, 31271223,
   QN2019014]; Hebei Province Higher Education Science and Technology
   Research Project [QN2019014]; Natural Science Foundation of Hebei
   Province [C2020206050];  [31071002]
FX This work was financially supported by the National Basic Research
   Development Program of China [grant number: 2012CB518200], the National
   Natural Science Foundation of China [grant numbers: 31671184, 31271223,
   31071002], Hebei Province Higher Education Science and Technology
   Research Project [grant number: QN2019014], and the Natural Science
   Foundation of Hebei Province [grant number: C2020206050]
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NR 45
TC 2
Z9 2
U1 0
U2 5
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, Maharashtra, INDIA
SN 0304-4920
EI 2666-0059
J9 CHINESE J PHYSIOL
JI Chin. J. Physiol.
PD MAR-APR
PY 2022
VL 65
IS 2
BP 53
EP 63
DI 10.4103/cjp.cjp_84_21
PG 11
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology
GA 1D1TY
UT WOS:000793591600001
PM 35488670
OA gold
DA 2025-06-11
ER

PT J
AU Pérez-Torres, I
   Torres-Narváez, JC
   Pedraza-Chaverri, J
   Rubio-Ruiz, ME
   Díaz-Díaz, E
   Del Valle-Mondragón, L
   Martínez-Memije, R
   López, EV
   Guarner-Lans, V
AF Perez-Torres, Israel
   Carlos Torres-Narvaez, Juan
   Pedraza-Chaverri, Jose
   Esther Rubio-Ruiz, Maria
   Diaz-Diaz, Eulises
   del Valle-Mondragon, Leonardo
   Martinez-Memije, Raul
   Varela Lopez, Elvira
   Guarner-Lans, Veronica
TI Effect of the Aged Garlic Extract on Cardiovascular Function in
   Metabolic Syndrome Rats
SO MOLECULES
LA English
DT Article
DE aged garlic extract; metabolic syndrome; cardiovascular functioning;
   oxidative stress
ID NITRIC-OXIDE SYNTHASE; HYDROGEN-SULFIDE; OXIDATIVE STRESS;
   ALLIUM-SATIVUM; BLOOD-PRESSURE; HYPERTENSION; ALLICIN; INSULIN;
   SUPPLEMENTATION; ANTIOXIDANT
AB The antioxidant properties of aged garlic extract (AGE) on cardiovascular functioning (CF) in metabolic syndrome (MS) remains poorly studied. Here we study the AGE effects on CF in a rat model of MS. Control rats plus saline solution (C + SS), MS rats (30% sucrose in drinking water from weaning) plus saline solution (MS + SS), control rats receiving AGE (C + AGE 125 mg/Kg/12 h) and MS rats with AGE (MS + AGE) were studied. MS + SS had increased triglycerides, systolic blood pressure, insulin, leptin, HOMA index, and advanced glycation end products. AGE returned their levels to control values (p < 0.01). Cholesterol was decreased by AGE (p = 0.05). Glutathion and GPx activity were reduced in MS + SS rats and increased with AGE (p = 0.05). Lipid peroxidation was increased in MS + SS and AGE reduced it (p = 0.001). Vascular functioning was deteriorated by MS (increased vasocontraction and reduced vasodilation) and AGE improved it (p = 0.001). Coronary vascular resistance was increased in MS rats and AGE decreased it (p = 0.001). Cardiac performance was not modified by MS but AGE increased it. NO measured in the perfusate liquid from the heart and serum citrulline, nitrites/nitrates were decreased in MS and AGE increased them (p < 0.01). In conclusion, AGE reduces MS-induced cardiovascular risk, through its anti-oxidant properties.
C1 [Perez-Torres, Israel] Inst Nacl Cardiol Ignacio Chavez, Dept Pathol, Juan Badiano 1,Secc 16, Mexico City 14080, DF, Mexico.
   [Carlos Torres-Narvaez, Juan; del Valle-Mondragon, Leonardo] Inst Nacl Cardiol Ignacio Chavez, Dept Pharmacol, Juan Badiano 1,Secc 16, Mexico City 14080, DF, Mexico.
   [Pedraza-Chaverri, Jose] Univ Nacl Autonoma Mexico, Dept Biol, Fac Quim, Lab 209, Edificio B,Ciudad Univ, Mexico City 04510, DF, Mexico.
   [Esther Rubio-Ruiz, Maria; Varela Lopez, Elvira; Guarner-Lans, Veronica] Inst Nacl Cardiol Ignacio Chavez, Dept Physiol, Juan Badiano 1,Secc 16, Mexico City 14080, DF, Mexico.
   [Diaz-Diaz, Eulises] Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Reprod Biol, Vasco de Quiroga 15,Secc 16, Mexico City 14000, DF, Mexico.
   [Martinez-Memije, Raul] Inst Nacl Cardiol Ignacio Chavez, Electromech Instrumentat, Juan Badiano 1,Secc 16, Mexico City 14080, DF, Mexico.
C3 National Institute of Cardiology - Mexico; National Institute of
   Cardiology - Mexico; Universidad Nacional Autonoma de Mexico; National
   Institute of Cardiology - Mexico; Instituto Nacional de Ciencias Medicas
   y Nutricion Salvador Zubiran - Mexico; National Institute of Cardiology
   - Mexico
RP Guarner-Lans, V (corresponding author), Inst Nacl Cardiol Ignacio Chavez, Dept Physiol, Juan Badiano 1,Secc 16, Mexico City 14080, DF, Mexico.
EM pertorisr@yahoo.com.mx; juancarlostn63@hotmail.com; pedraza@unam.mx;
   esther_rubio_ruiz@yahoo.com; eulisesd@yahoo.com;
   leonardodvm65@hotmail.com; raulmmemije@yahoo.com; varelopz@yahoo.com;
   gualanv@yahoo.com
RI Guarner-Lans, Verónica/AFW-3723-2022; Pérez Torres, Israel/AAE-2579-2022
OI Guarner-Lans, Veronica/0000-0002-2655-7590; del Valle-Mondragon,
   Leonardo/0000-0002-2999-1050; Perez-Torres, Israel/0000-0001-6510-2954
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NR 60
TC 35
Z9 39
U1 0
U2 11
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1420-3049
J9 MOLECULES
JI Molecules
PD NOV
PY 2016
VL 21
IS 11
AR 1425
DI 10.3390/molecules21111425
PG 15
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA EE9AO
UT WOS:000389918200009
PM 27792195
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Smith, KW
   Krieger, N
   Kosheleva, A
   Urato, M
   Waterman, PD
   Williams, DR
   Carney, DR
   Chen, JT
   Bennett, GG
   Freeman, E
AF Smith, Kevin W.
   Krieger, Nancy
   Kosheleva, Anna
   Urato, Matthew
   Waterman, Pamela D.
   Williams, David R.
   Carney, Dana R.
   Chen, Jarvis T.
   Bennett, Gary G.
   Freeman, Elmer
TI A STRUCTURAL MODEL OF SOCIAL DETERMINANTS OF THE METABOLIC SYNDROME
SO ETHNICITY & DISEASE
LA English
DT Article
DE Metabolic Syndrome; Structural quation Models; Discrimination
ID CARDIOVASCULAR-DISEASE; RISK; DISCRIMINATION; HOSTILITY; STRESS; HEALTH;
   WOMEN; QUESTIONNAIRE; ASSOCIATION; RELIABILITY
AB Objectives: The metabolic syndrome (MetS) refers to a cluster of interrelated physiological characteristics that are associated with an increased risk of cardiovascular disease and diabetes. While the clinical usefulness of the MetS has been the subject. of controversy for years, increasingly sophisticated methods are being used to measure the concept.
   Participants: Study of community health center patients who were not diabetic; study group was evenly divided between Black and White adults.
   Methods: Structural equation modeling of MetS incorporating the effects of race/ethnicity, racial discrimination, socioeconomic position (SEP), and selected mediating variables.
   Main Outcome Measure: Latent MetS score and MetS status based on the five-point scale developed by the National Cholesterol Education Panel (NCEP).
   Results: The largest influences on latent MetS scores were SEP (negative relationship) and male gender (higher scores for men). Two mediating variables, physical activity and stress-related eating, had smaller impacts. Self-reported racial discrimination was associated with cynical hostility but did not influence the MetS level among nondiabetics. Despite higher NCEP scores and MetS prevalence rates for Blacks compared with Whites, race did not have direct effect on MetS levels when adjusted for the other characteristics in our model.
   Conclusions: Neither race nor self-reported racial discrimination had direct effects on MetS level in our structural model. The large effects of socioeconomic position and male gender were not mediated by the other variables in the model.
C1 [Smith, Kevin W.] RTI Int, 307 Waverley Oaks Rd,Suite 101, Waltham, MA 02452 USA.
   [Krieger, Nancy; Kosheleva, Anna; Waterman, Pamela D.; Williams, David R.; Chen, Jarvis T.] Harvard Sch Publ Hlth, Dept Social & Behav Sci, Boston, MA USA.
   [Urato, Matthew] RTI Int, Res Triangle Pk, NC USA.
   [Carney, Dana R.] Univ Calif Berkeley, Haas Sch Business, Berkeley, CA 94720 USA.
   [Bennett, Gary G.] Duke Univ, Psychol & Neurosci, Durham, NC USA.
   [Bennett, Gary G.] Duke Univ, Duke Global Hlth Initiat, Durham, NC USA.
   [Freeman, Elmer] CCHERS, Boston, MA USA.
C3 Research Triangle Institute; Harvard University; Harvard T.H. Chan
   School of Public Health; Research Triangle Institute; University of
   California System; University of California Berkeley; Duke University;
   Duke University
RP Smith, KW (corresponding author), RTI Int, 307 Waverley Oaks Rd,Suite 101, Waltham, MA 02452 USA.
EM kevinsmith@rti.org
RI Williams, David/JEO-2461-2023
OI Krieger, Nancy/0000-0002-4815-5947
FU (National Institutes of Health/National Institute on Aging) [1 R01
   AG027122-01, R01 AG27122-351]
FX This study was funded by the National Institutes of Health/National
   Institute on Aging)1 R01 AG027122-01 and R01 AG27122-351. The funder had
   no role in study design, data collection, data analysis, manuscript
   preparation, or decision to publish.
CR [Anonymous], 2014, SOCIAL EPIDEMIOLOGY
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NR 40
TC 5
Z9 6
U1 1
U2 12
PU INT SOC HYPERTENSION BLACKS-ISHIB
PI ATLANTA
PA 100 AUBURN AVE NE STE 401, ATLANTA, GA 30303-2527 USA
SN 1049-510X
EI 1945-0826
J9 ETHNIC DIS
JI Ethn. Dis.
PD SPR
PY 2020
VL 30
IS 2
BP 331
EP 338
DI 10.18865/ed.30.2.331
PG 8
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA LG7SG
UT WOS:000528295300012
PM 32346279
OA Green Published
DA 2025-06-11
ER

PT J
AU Uchinaka, A
   Kawashima, Y
   Sano, Y
   Ito, S
   Sano, Y
   Nagasawa, K
   Matsuura, N
   Yoneda, M
   Yamada, Y
   Murohara, T
   Nagata, K
AF Uchinaka, Ayako
   Kawashima, Yuri
   Sano, Yuki
   Ito, Shogo
   Sano, Yusuke
   Nagasawa, Kai
   Matsuura, Natsumi
   Yoneda, Mamoru
   Yamada, Yuichiro
   Murohara, Toyoaki
   Nagata, Kohzo
TI Effects of ramelteon on cardiac injury and adipose tissue pathology in
   rats with metabolic syndrome
SO ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
LA English
DT Article
DE melatonin; white adipose tissue; brown adipose tissue; cardiac
   remodeling; metabolic syndrome
ID 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE-1; SPONTANEOUSLY
   HYPERTENSIVE-RATS; DIABETIC FATTY RATS; OXIDATIVE STRESS;
   INSULIN-RESISTANCE; ENERGY-EXPENDITURE; HEART-FAILURE; DIASTOLIC
   DYSFUNCTION; VISCERAL ADIPOSITY; BLOOD-PRESSURE
AB Melatonin regulates circadian rhythms but also has antioxidative and anti-inflammatory effects that ameliorate metabolic disorders. We investigated the effects of the selective melatonin agonist ramelteon on cardiac and adipose tissue pathology in the DahlS.Z-Lepr(fa)/Lepr(fa) (DS/obese) rat, a model of metabolic syndrome(MetS). Rats were treated with a low (0.3 mg/kg per day) or high (8 mg/kg per day) dose of ramelteon from 9 to 13 weeks of age. Ramelteon treatment at either dose attenuated body weight gain, left ventricular fibrosis, and diastolic dysfunction, as well as cardiac oxidative stress and inflammation, without affecting hypertension or insulin resistance. Although ramelteon did not affect visceral white adipose tissue (WAT) mass, it attenuated inflammation and downregulated insulin signaling in this tissue. In contrast, ramelteon reduced fat mass, adipocyte hypertrophy, and inflammation, and ameliorated impaired insulin signaling in subcutaneous WAT. In addition, ramelteon attenuated adipocyte hypertrophy, downregulated mitochondrial uncoupling protein 1, and upregulated 11 beta-hydroxysteroid dehydrogenase type 1 expression in interscapular brown adipose tissue (BAT). In summary, ramelteon treatment attenuated obesity and cardiac injury, improved insulin signaling in visceral and subcutaneous WAT, and inhibited the whitening of BAT in rats with MetS.
C1 [Uchinaka, Ayako; Ito, Shogo; Sano, Yusuke; Nagasawa, Kai; Matsuura, Natsumi; Yoneda, Mamoru; Yamada, Yuichiro; Nagata, Kohzo] Nagoya Univ, Grad Sch Med, Dept Pathophysiol Lab Sci, Nagoya, Aichi, Japan.
   [Kawashima, Yuri; Sano, Yuki] Nagoya Univ, Sch Hlth Sci, Dept Med Technol, Nagoya, Aichi, Japan.
   [Murohara, Toyoaki] Nagoya Univ, Grad Sch Med, Dept Cardiol, Nagoya, Aichi, Japan.
C3 Nagoya University; Nagoya University; Nagoya University
RP Nagata, K (corresponding author), Nagoya Univ, Grad Sch Med, Dept Pathophysiol Lab Sci, Higashi Ku, 1-1-20 Daikominami, Nagoya, Aichi 4618673, Japan.
EM nagata@met.nagoya-u.ac.jp
RI Murohara, Toyoaki/M-4958-2014
FU Suzuken Memorial Foundation (Nagoya, Japan); EA Pharma Co. Ltd. (Tokyo,
   Japan)
FX We are grateful to Takeda Pharmaceutical Co. Ltd. (Osaka, Japan) for
   ramelteon. We thank Shogo Watanabe, Moeno Shibata, and Asami Fukuma for
   technical assistance. This work was supported by a research grant from
   the Suzuken Memorial Foundation (Nagoya, Japan) and by unrestricted
   grants from Ajinomoto Pharmaceuticals Co. Ltd. (Tokyo, Japan), Kohzo
   Nagata, Tomohisa Itosu, Makoto Hirai, EA Pharma Co. Ltd. (Tokyo, Japan),
   and Kunihiko Sugimoto to Dr. Nagata.
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NR 64
TC 9
Z9 9
U1 0
U2 13
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0077-8923
EI 1749-6632
J9 ANN NY ACAD SCI
JI Ann. N.Y. Acad. Sci.
PD JUN
PY 2018
VL 1421
IS 1
SI SI
BP 73
EP 87
DI 10.1111/nyas.13578
PG 15
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA GJ0MO
UT WOS:000434948700006
PM 29542814
DA 2025-06-11
ER

PT J
AU Dzidic-Krivic, A
   Fajkic, A
   Farhat, EK
   Lekic, L
   Ejubovic, A
   Vukas, SK
   Ejubovic, M
   Lepara, O
   Sher, EK
AF Dzidic-Krivic, Amina
   Fajkic, Almir
   Farhat, Esma Karahmet
   Lekic, Lana
   Ejubovic, Amira
   Vukas, Samra Kadic
   Ejubovic, Malik
   Lepara, Orhan
   Sher, Emina Karahmet
TI Linking Metabolic Syndrome to Neurodegeneration Mechanisms and Potential
   Treatments
SO MOLECULAR NEUROBIOLOGY
LA English
DT Review; Early Access
DE Metabolic syndrome; Neurodegenerative diseases; Inflammation;
   Astrocytes; Mitochondrial damage; Obesity; Insulin resistance; Improved
   nutrition; Health
ID ALZHEIMERS-DISEASE; GLOBAL BURDEN; DEMENTIA; INTERVENTION; MICROBIOTA;
   ADULTS; IMPACT; RISK
AB The global rise in both metabolic syndrome (MetS) and neurodegenerative diseases (NDs), particularly dementia and Alzheimer's disease (AD) poses a growing health and socioeconomic burden. MetS affects approximately 25% of the global adult population and is associated with insulin resistance, hypertension, dyslipidemia, and obesity, factors increasingly linked to cognitive impairment and brain atrophy. This review explores the shared pathophysiological mechanisms between MetS and NDs, including neuroinflammation, oxidative stress, insulin resistance in the brain, blood-brain barrier (BBB) dysfunction, mitochondrial damage, gut microbiota dysbiosis, and alterations in the renin-angiotensin system. In terms of substance, MetS patients are four times more likely to develop dementia, with increased markers such as CRP and IL-6 present in the patient populations. The review suggests the role of astrocytic insulin signalling, adipokines, and toll-like receptors as key molecular links. Interventions such as caloric restriction, hydroxytyrosol (HT), and intranasal insulin have shown promising outcomes at preclinical and early clinical stages. Antidiabetic drugs like metformin, liraglutide, and GLP-1 receptor agonists have the potential to modulate neuroinflammation and improve cognition. Angiotensin receptor blockers like losartan and candesartan also exhibit neuroprotection via RAS pathway modulation. The review emphasizes the need for longitudinal studies and clinical trials to confirm these therapeutic agents and develop effective and cost-friendly interventions for the prevention and management of neurodegeneration in patients with metabolic syndrome.
C1 [Dzidic-Krivic, Amina; Vukas, Samra Kadic] Cantonal Hosp Zenica, Dept Neurol, Zenica 72000, Bosnia & Herceg.
   [Ejubovic, Amira; Ejubovic, Malik] Cantonal Hosp Zenica, Dept Internal Med, Zenica 72000, Bosnia & Herceg.
   [Dzidic-Krivic, Amina; Ejubovic, Malik] Univ Zenica, Fac Med, Zenica 72000, Bosnia & Herceg.
   [Farhat, Esma Karahmet] Juraj Strossmayer Univ Osijek, Fac Food Technol, Osijek 31000, Croatia.
   [Lekic, Lana] Univ Sarajevo, Fac Hlth Studies, Sarajevo 71000, Bosnia & Herceg.
   [Farhat, Esma Karahmet; Sher, Emina Karahmet] Int Soc Engn Sci & Technol, Nottingham, England.
   [Fajkic, Almir] Univ Sarajevo, Fac Med, Dept Pathophysiol, Sarajevo 71000, Bosnia & Herceg.
   [Lepara, Orhan] Univ Sarajevo, Fac Med, Dept Human Physiol, Sarajevo 71000, Bosnia & Herceg.
   [Sher, Emina Karahmet] Nottingham Trent Univ, Sch Sci & Technol, Nottingham NG11 8NS, England.
C3 University of Zenica; University of Sarajevo; University of Sarajevo;
   University of Sarajevo; Nottingham Trent University
RP Sher, EK (corresponding author), Int Soc Engn Sci & Technol, Nottingham, England.; Sher, EK (corresponding author), Nottingham Trent Univ, Sch Sci & Technol, Nottingham NG11 8NS, England.
EM emina.sher@isest.org
RI Lepara, Orhan/AAM-5752-2021; Sher, Emina/AGO-8756-2022
FU International Society of Engineering Science and Technology
FX The authors are grateful to the International Society of Engineering
   Science and Technology for their support.
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NR 134
TC 0
Z9 0
U1 1
U2 1
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0893-7648
EI 1559-1182
J9 MOL NEUROBIOL
JI Mol. Neurobiol.
PD 2025 APR 24
PY 2025
DI 10.1007/s12035-025-04947-w
EA APR 2025
PG 23
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 1UC1G
UT WOS:001473684200001
PM 40272771
DA 2025-06-11
ER

PT J
AU Deng, ZZ
   Wu, N
   Wang, J
   Geng, LH
   Yue, Y
   Wang, FH
   Zhang, QB
AF Deng, Zhenzhen
   Wu, Ning
   Wang, Jing
   Geng, Lihua
   Yue, Yang
   Wang, Fahe
   Zhang, Quanbin
TI Low molecular weight fucoidan fraction LF2 improves metabolic syndrome
   via up-regulating PI3K-AKT-mTOR axis and increasing the abundance of
   Akkermansia muciniphila in the gut microbiota
SO INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
LA English
DT Article
DE Fucoidan; Metabolic syndrome; Gut microbiota
ID DIET-INDUCED DYSLIPIDEMIA; DIABETIC-NEPHROPATHY; INSULIN-RESISTANCE;
   MOUSE MODEL; OBESITY; LIVER; INFLAMMATION; MICE; ASSOCIATION; STEATOSIS
AB Metabolic syndrome (MetS) is a pathological condition of a variety of metabolic abnormalities, which requires more urgent treatment and intervention. Fucoidan has been recommended as a supplement for health enhancement and disease management. Here, we first propose that the beneficial effect of low molecular weight fucoidan fraction LF2 in regulating metabolic syndrome induced by high-fat diet is similar to that of metformin, in terms of molecular mechanism and gut microbiota. The study found that LF2 significantly reduces fasting blood glucose, enhances insulin sensitivity and restores insulin homeostasis and lipid homeostasis. Moreover, LF2 reduced liver oxidative stress and inflammation, and improved hepatocyte steatosis. To decipher the mechanism behind this therapeutic effect, both the molecular mechanisms and gut microbiota were further analyzed. LF2 inhibited the activation of PI3K-Akt-mTOR axis and decreased the expression of SREBP-1c and PPAR gamma in liver. Interestingly, we found that LF2 and metformin have similar effects on gut microbiota, increasing the proportion of Verrucomicrobia and enriching the abundance of Akkermansia muciniphila, which is beneficial to host health. Collectively, our research clarifies the new application of fucoidan as a functional food for anti-MetS, and provides a new insight for fucoidan to exert systemic therapeutic effects from the perspective of molecular mechanism and gut microbiota.
C1 [Deng, Zhenzhen; Wu, Ning; Wang, Jing; Geng, Lihua; Yue, Yang; Zhang, Quanbin] Chinese Acad Sci, Inst Oceanol, CAS & Shandong Prov Key Lab Expt Marine Biol, Ctr Ocean Mega Sci, Qingdao 266071, Peoples R China.
   [Deng, Zhenzhen; Wu, Ning; Wang, Jing; Geng, Lihua; Yue, Yang; Zhang, Quanbin] Qingdao Natl Lab Marine Sci & Tech, Lab Marine Biol & Biotechnol, Qingdao 266071, Peoples R China.
   [Deng, Zhenzhen; Zhang, Quanbin] Univ Chinese Acad Sci, Beijing 100049, Peoples R China.
   [Wang, Fahe] Qingdao Brightmoon Seaweed Grp Co Ltd, State Key Lab Bioact Seaweed Subst, Qingdao, Peoples R China.
C3 Chinese Academy of Sciences; Institute of Oceanology, CAS; Laoshan
   Laboratory; Chinese Academy of Sciences; University of Chinese Academy
   of Sciences, CAS
RP Zhang, QB (corresponding author), Chinese Acad Sci, Inst Oceanol, CAS & Shandong Prov Key Lab Expt Marine Biol, Ctr Ocean Mega Sci, Qingdao 266071, Peoples R China.
EM qbzhang@qdio.ac.cn
RI Zhang, Quanbin/IUQ-3663-2023
FU Major Scientific & Engineering Projects of Innovation in Shandong
   Province [2019JZZY010818]; National Natural Science Fundation of China
   [42176137]; STS project of the Chinese Academy of Sciences
   [KFJSTS-QYZD-195]; Special Open Fund of Laboratory for Marine Biology
   and Biotechnology, Qingdao Pilot National Laboratory for Marine Science
   and Technology [OF2020NO02]; K.C. Wong Education Foundation, CAS
FX The research was supported by the Major Scientific & Engineering
   Projects of Innovation in Shandong Province (Grant No. 2019JZZY010818);
   National Natural Science Fundation of China (Grand No. 42176137), STS
   project of the Chinese Academy of Sciences (KFJSTS-QYZD-195), the
   Special Open Fund of Laboratory for Marine Biology and Biotechnology,
   Qingdao Pilot National Laboratory for Marine Science and Technology (No.
   OF2020NO02); and K.C. Wong Education Foundation, CAS.
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NR 49
TC 25
Z9 28
U1 9
U2 90
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0141-8130
EI 1879-0003
J9 INT J BIOL MACROMOL
JI Int. J. Biol. Macromol.
PD DEC 15
PY 2021
VL 193
BP 789
EP 798
DI 10.1016/j.ijbiomac.2021.10.188
EA NOV 2021
PN A
PG 10
WC Biochemistry & Molecular Biology; Chemistry, Applied; Polymer Science
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry; Polymer Science
GA XN5PU
UT WOS:000729557700002
PM 34743939
DA 2025-06-11
ER

PT J
AU Saedi, S
   Watson, SE
   Young, JL
   Tan, Y
   Wintergerst, KA
   Cai, L
AF Saedi, Saman
   Watson, Sara E.
   Young, Jamie L.
   Tan, Yi
   Wintergerst, Kupper A.
   Cai, Lu
TI Does maternal low-dose cadmium exposure increase the risk of offspring
   to develop metabolic syndrome and/or type 2 diabetes?
SO LIFE SCIENCES
LA English
DT Article
DE Type 2 diabetes; Cadmium; Metabolic syndrome; Offspring; Maternal
   exposure; Insulin resistance
ID GROWTH-FACTOR-I; IMPAIRED GLUCOSE-TOLERANCE; LOW-LEVEL CADMIUM;
   INSULIN-SECRETION; RETINOIC ACID; CARDIOVASCULAR-DISEASE; OXIDATIVE
   STRESS; BLOOD CADMIUM; IGF-I; HEALTH
AB Cadmium is a hazardous metal with multiple organ toxicity that causes great harm to human health. Cadmium enters the human body through occupational exposure, diet, drinking water, breathing, and smoking. Cadmium accumulation in the human body is associated with increased risk of developing obesity, cardiovascular disease, diabetes, and metabolic syndrome (MetS). Cadmium uptake is enhanced during pregnancy and can cross the placenta affecting placental development and function. Subsequently, cadmium can pass to fetus, gathering in multiple organs such as the liver and pancreas. Early-life cadmium exposure can induce hepatic oxidative stress and pancreatic beta-cell dysfunction, resulting in insulin resistance and glucose metabolic dyshomeostasis in the offspring. Prenatal exposure to cadmium is also associated with increasing epigenetic effects on the offspring's multi-organ functions. However, whether and how maternal exposure to low-dose cadmium impacts the risks of developing type 2 diabetes (T2D) in the young and/or adult offspring remains unclear. This review collected available data to address the current evidence for the potential role of cadmium exposure, leading to insulin resistance and the development of T2D in offspring. However, this review reveals that underlying mechanisms linking prenatal cadmium exposure during pregnancy with T2D in offspring remain to be adequately investigated.
C1 [Saedi, Saman] Shiraz Univ, Coll Agr, Dept Anim Sci, Shiraz, Iran.
   [Watson, Sara E.; Tan, Yi; Wintergerst, Kupper A.; Cai, Lu] Univ Louisville, Pediat Res Inst, Sch Med, Dept Pediat, Louisville, KY 40202 USA.
   [Watson, Sara E.; Wintergerst, Kupper A.; Cai, Lu] Norton Childrens Hosp, Diabet Inst, Louisville, KY USA.
   [Watson, Sara E.; Wintergerst, Kupper A.] Univ Louisville, Norton Childrens Hosp, Dept Pediat, Div Endocrinol, Louisville, KY USA.
   [Young, Jamie L.; Tan, Yi; Cai, Lu] Univ Louisville, Sch Med, Dept Pharmacol & Toxicol, Louisville, KY 40202 USA.
   [Young, Jamie L.; Wintergerst, Kupper A.; Cai, Lu] Univ Louisville, Ctr Integrat Environm Hlth Sci, Sch Med, Louisville, KY USA.
   [Cai, Lu] Univ Louisville, Sch Med, Dept Radiat Oncol, Louisville, KY 40202 USA.
   [Cai, Lu] Pediat Res Inst, 570 S Preston St,Baxter 1,Rm 304F, Louisville, KY 40202 USA.
C3 Shiraz University; University of Louisville; University of Louisville;
   University of Louisville; University of Louisville; University of
   Louisville
RP Cai, L (corresponding author), Pediat Res Inst, 570 S Preston St,Baxter 1,Rm 304F, Louisville, KY 40202 USA.
EM lu.cai@louisville.edu
FU National Institute of Environmental Health Sciences [P30ES030283,
   T32ES011564]; Jewish Heritage Fund for Excellence Faculty Recruitment
   Grant Program at the University of Louisville, School of Medicine;
   National Heart, Lung, and Blood Institute [R01HL125877, R01HL160927]
FX The works of the authors is supported in part by grants from the
   National Institute of Environmental Health Sciences (P30ES030283 to JLY,
   KW, LC; T32ES011564 to JLY) ; the Jewish Heritage Fund for Excellence
   Faculty Recruitment Grant Program at the University of Louisville,
   School of Medicine (to JLY) and the National Heart, Lung, and Blood
   Institute (R01HL125877, R01HL160927 to YT, LC) .
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NR 143
TC 18
Z9 18
U1 1
U2 23
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0024-3205
EI 1879-0631
J9 LIFE SCI
JI Life Sci.
PD FEB 15
PY 2023
VL 315
AR 121385
DI 10.1016/j.lfs.2023.121385
EA JAN 2023
PG 9
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA E5XT6
UT WOS:000976277600001
PM 36634865
OA Bronze, Green Accepted
DA 2025-06-11
ER

PT J
AU Marzolla, V
   Armani, A
   Zennaro, MC
   Cinti, F
   Mammi, C
   Fabbri, A
   Rosano, GMC
   Caprio, M
AF Marzolla, Vincenzo
   Armani, Andrea
   Zennaro, Maria-Christina
   Cinti, Francesca
   Mammi, Caterina
   Fabbri, Andrea
   Rosano, Giuseppe M. C.
   Caprio, Massimiliano
TI The role of the mineralocorticoid receptor in adipocyte biology and fat
   metabolism
SO MOLECULAR AND CELLULAR ENDOCRINOLOGY
LA English
DT Review
DE Mineralocorticoid receptor; Adipocyte; Adipose tissue; Metabolic
   syndrome
ID BROWN ADIPOSE-TISSUE; VENTRICULAR DIASTOLIC DYSFUNCTION;
   ANGIOTENSIN-ALDOSTERONE SYSTEM; HORMONE REPLACEMENT THERAPY;
   PITUITARY-ADRENAL AXIS; BLOOD-PRESSURE; POSTMENOPAUSAL WOMEN;
   11-BETA-HYDROXYSTEROID DEHYDROGENASE; INSULIN-RESISTANCE; OXIDATIVE
   STRESS
AB Aldosterone controls blood pressure by binding to the mineralocorticoid receptor (MR), a ligand-activated transcription factor which regulates critical genes controlling salt and water homeostasis in the kidney. In recent years, inappropriate MR activation has been shown to trigger deleterious responses in various tissues, including vessels, heart and brain, hence promoting vascular inflammation, cardiovascular remodeling, endothelial dysfunction, and oxidative stress. Moreover, epidemiological studies have shown a clear association between aldosterone levels and the incidence of metabolic syndrome. In particular, recent work has revealed functional MRs in adipose tissue, where they mediate the effects of aldosterone and glucocorticoids, displaying important and specific functions involving adipose differentiation, expansion and proinflammatory capacity. This recent evidence finally moved MR out of the shadow of the glucocorticoid receptor (GR), which had previously been considered the only player mediating corticosteroid action in adipose tissue. This has opened a new era of research focusing on the complexity and selectivity of MR function in adipocyte biology.
   The aim of this review is to summarize the latest concepts on the role of MR in white and brown adipocytes, and to discuss the potential benefits of tissue-selective MR blockade in the treatment of obesity and metabolic syndrome. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
C1 [Armani, Andrea; Cinti, Francesca; Mammi, Caterina; Rosano, Giuseppe M. C.; Caprio, Massimiliano] IRCCS San Raffaele Pisana, Ctr Clin & Basic Res, Rome, Italy.
   [Marzolla, Vincenzo] San Raffaele Sulmona, Sulmona, AQ, Italy.
   [Zennaro, Maria-Christina] Paris Cardiovasc Res Ctr PARCC, INSERM, U970, Paris, France.
   [Zennaro, Maria-Christina] Univ Paris 05, UMR S970, Paris, France.
   [Zennaro, Maria-Christina] Hop Europeen Georges Pompidou, AP HP, Paris, France.
   [Fabbri, Andrea] Univ Roma Tor Vergata, Dept Internal Med, Endocrinol Unit, S Eugenio Hosp, Rome, Italy.
   [Fabbri, Andrea] Univ Roma Tor Vergata, Dept Internal Med, Endocrinol Unit, CTO A Alesini Hosp, Rome, Italy.
C3 IRCCS San Raffaele Pisana; Center Clinical & Basic Research; Institut
   National de la Sante et de la Recherche Medicale (Inserm); Universite
   Paris Cite; Universite Paris Cite; Assistance Publique Hopitaux Paris
   (APHP); Universite Paris Cite; Hopital Universitaire Europeen
   Georges-Pompidou - APHP; Sant'Eugenio Hospital; University of Rome Tor
   Vergata; University of Rome Tor Vergata
RP Caprio, M (corresponding author), IRCCS San Raffaele, Lab Cardiovasc Endocrinol, Via Val Cannuta 247, I-00166 Rome, Italy.
EM massimiliano.caprio@sanraffaele.it
RI Rosano, Giuseppe/K-8718-2018; Armani, Andrea/AAC-2071-2022; Zennaro,
   Maria-Christina/IZP-8913-2023; Mammi, Caterina/O-1047-2013; Caprio,
   Massimiliano/J-3020-2012; Cinti, Francesca/AAY-5534-2021; Marzolla,
   Vincenzo/K-7769-2016
OI Caprio, Massimiliano/0000-0003-0722-7163; Cinti,
   Francesca/0000-0001-5170-7055; Zennaro,
   Maria-Christina/0000-0001-5449-9191; ARMANI, Andrea/0000-0002-2130-1596;
   Marzolla, Vincenzo/0000-0002-2943-7631; mammi,
   caterina/0000-0002-2687-4422
FU IRCCS San Raffaele Pisana (Ricerca Corrente); University Tor Vergata
FX The authors wish to thank Antonella Antelmi for precious technical
   support, and Morag J. Young for English editing. This work was supported
   by institutional fundings from IRCCS San Raffaele Pisana (Ricerca
   Corrente) and University Tor Vergata (Progetti Ricerca Interesse
   Nazionale Ministero dell'Universita e della Ricerca, 2009).
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NR 96
TC 98
Z9 112
U1 0
U2 22
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0303-7207
J9 MOL CELL ENDOCRINOL
JI Mol. Cell. Endocrinol.
PD MAR 24
PY 2012
VL 350
IS 2
SI SI
BP 281
EP 288
DI 10.1016/j.mce.2011.09.011
PG 8
WC Cell Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Endocrinology & Metabolism
GA 902DY
UT WOS:000301020000017
PM 21945603
DA 2025-06-11
ER

PT J
AU Mossa, AH
   Shamout, S
   Cammisotto, P
   Campeau, L
AF Mossa, Abubakr H.
   Shamout, Samer
   Cammisotto, Philippe
   Campeau, Lysanne
TI Urinary metabolomics predict the severity of overactive bladder syndrome
   in an aging female population
SO INTERNATIONAL UROGYNECOLOGY JOURNAL
LA English
DT Article; Proceedings Paper
CT 48th Annual Meeting of the International-Continence-Society
CY AUG 28-31, 2018
CL Philadelphia, PA
SP Int Continence Soc
DE Overactive bladder; Aging female; Urinary metabolomics; Metabolic
   disease; Krebs cycle
ID PYROGLUTAMIC ACID; SUCCINATE; SYMPTOMS
AB Introduction and hypothesis To identify urinary metabolites that can facilitate the diagnosis and the characterization of the underlying pathophysiology of the association between the overactive bladder syndrome (OAB) and metabolic syndrome. Methods We used gas chromatography-mass spectrometry to compare the urinary metabolome of 20 females of 50-80 years of age with OAB to that of 20 controls of the same age group. We performed urinary metabolomic analysis and obtained serum markers of metabolic syndrome for each subject. Participants completed a clinical evaluation and validated self-reported questionnaires of lower urinary tract symptoms as well as a one-day voiding diary. Results In the OAB subjects, we identified increased urinary levels of markers of mitochondrial dysfunction (itaconate, malate and fumarate), oxidative stress (L-pyroglutamate and alpha-hydroxyglutarate) and ketosis (alpha-hydroxybutyrate and alpha-hydroxyisobutyrate). The increased levels of these markers correlated significantly with the OAB symptoms score on questionnaires. We found, using a multiple linear regression model, that age, blood glucose and urine metabolites (malate, fumarate and alpha-hydroxyisobutyrate) were significant predictive factors of OAB severity. Fumarate had high sensitivity as a biomarker of OAB due to metabolic syndrome, based on a statistically significant receiver-operating characteristic (ROC) curve, indicating its potential as a diagnostic tool. Conclusions Altogether, these findings establish that urinary metabolites of mitochondrial dysfunction, ketosis and oxidative stress can be potential biomarkers of OAB severity and diagnosis.
C1 [Mossa, Abubakr H.; Shamout, Samer; Cammisotto, Philippe; Campeau, Lysanne] McGill Univ, Lady Davis Inst Med Res, 3755 Chemin Cote Ste Catherine, Montreal, PQ H3T 1E2, Canada.
   [Shamout, Samer; Campeau, Lysanne] McGill Univ, Jewish Gen Hosp, Dept Surg, Div Urol, Montreal, PQ, Canada.
C3 McGill University; Lady Davis Institute; Jewish General Hospital -
   Montreal; McGill University
RP Campeau, L (corresponding author), McGill Univ, Lady Davis Inst Med Res, 3755 Chemin Cote Ste Catherine, Montreal, PQ H3T 1E2, Canada.; Campeau, L (corresponding author), McGill Univ, Jewish Gen Hosp, Dept Surg, Div Urol, Montreal, PQ, Canada.
EM lysanne.campeau@mcgill.ca
RI Mossa, Abubakr/GRN-8072-2022; Cammisotto, Philippe/GSD-6497-2022
OI Mossa, Abubakr/0000-0002-9101-113X
FU Réseau québécois de recherche sur le vieillissement (CA) [NA] Funding
   Source: Medline; Urology Care Foundation Rising Star in Urology Research
   Award [NA] Funding Source: Medline
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NR 26
TC 10
Z9 10
U1 2
U2 5
PU SPRINGER LONDON LTD
PI LONDON
PA 236 GRAYS INN RD, 6TH FLOOR, LONDON WC1X 8HL, ENGLAND
SN 0937-3462
EI 1433-3023
J9 INT UROGYNECOL J
JI Int. Urogynecol. J.
PD MAY
PY 2020
VL 31
IS 5
BP 1023
EP 1031
DI 10.1007/s00192-019-04175-6
PG 9
WC Obstetrics & Gynecology; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Obstetrics & Gynecology; Urology & Nephrology
GA LK9DG
UT WOS:000531157500025
PM 31813035
DA 2025-06-11
ER

PT J
AU Mayas, MD
   Queipo-Ortuño, MI
   Clemente-Postigo, M
   Macias, M
   El Bekay, R
   Tinahones, FJ
   Cardona, F
AF Dolores Mayas, Maria
   Isabel Queipo-Ortuno, Maria
   Clemente-Postigo, Mercedes
   Macias, Manuel
   El Bekay, Rajaa
   Jose Tinahones, Francisco
   Cardona, Fernando
TI Influence of a fat overload on lipogenic regulators in metabolic
   syndrome patients
SO BRITISH JOURNAL OF NUTRITION
LA English
DT Article
DE Genetic expression; Postprandial hypertriacylglycerolaemia; Lipogenic
   genes
ID X-RECEPTOR; SREBP-1C TRANSCRIPTION; LIPID HOMEOSTASIS; OXIDATIVE STRESS;
   EXPRESSION; ELEMENT; LIVER; BINDING; LXR; GENE
AB Several epidemiological studies have related an increase of lipids in the postprandial state to an individual risk for the development of CVD, possibly due to the increased plasma levels of TAG and fatty acids (FA) through enzymes of FA metabolism. The interaction between nutrition and the human genome determines gene expression and metabolic response. The aim of the present study was to evaluate the influence of a fat overload on the gene mRNA levels of lipogenic regulators in peripheral blood mononuclear cells (PBMC) from patients with the metabolic syndrome. The study included twenty-one patients with criteria for the metabolic syndrome who underwent a fat overload. Measurements were made before and after the fat overload of anthropometric and biochemical variables and also the gene mRNA levels of lipogenic factors. The main results were that the fat overload led to an increased mRNA levels of sterol regulatory element binding protein-1 (SREBP1), retinoid X receptor a (RXR alpha) and liver X receptor a (LXR alpha) in PBMC, and this increase was associated with the FA synthase (FASN) mRNA levels. We also found that TAG levels correlated with FASN mRNA levels. In addition, there was a positive correlation of SREBP1 with RXRa and of LXR alpha with the plasma lipoperoxide concentration. The fat overload led to an increase in regulators of lipogenesis in PBMC from patients with the metabolic syndrome.
C1 [Dolores Mayas, Maria; Clemente-Postigo, Mercedes; Macias, Manuel; El Bekay, Rajaa; Cardona, Fernando] Hosp Virgen Victoria Malaga, Fdn IMABIS, Lab Invest, Malaga, Spain.
   [Jose Tinahones, Francisco] Hosp Virgen Victoria Malaga, Serv Endocrinol & Nutr, Malaga, Spain.
C3 FIMABIS
EM fernandocardonadiaz@gmail.com
RI Cardona, Fernando/AAG-7835-2019; Clemente-Postigo,
   Mercedes/AAA-1102-2020; Bekay, Rajaa/AAZ-3959-2020; Ortuño,
   María/AAC-1238-2021; Tinahones, Francisco/AAB-2882-2020; Cardona,
   Fernando/H-6022-2015
OI El Bekay Rizky, RAJAA/0000-0003-3332-3431; Tinahones, Francisco
   J/0000-0001-6871-4403; QUEIPO ORTUNO, MARIA ISABEL/0000-0002-2867-0845;
   Clemente-Postigo, Mercedes/0000-0002-4146-6662; Cardona,
   Fernando/0000-0003-4460-6824
FU Instituto de Salud Carlos III [PS09/00997, PI081655, CP07/0095];
   Consejeria de Innovacion, Ciencia y Empresa [PI 325/08]
FX The present study was supported by the Instituto de Salud Carlos III
   (PS09/00997, PI081655 and CP07/0095) and Consejeria de Innovacion,
   Ciencia y Empresa (PI 325/08). There are no conflicts of interest. M. D.
   M. participated in drafting the manuscript, the genetic studies and in
   performing the statistical analysis. M. I. Q.-O. and M. C.-P.
   participated in the analysis of biochemical variables and in the
   statistical analysis. M. M. and R. E. B. were scientific advisers. F. J.
   T. and F. C. designed the research and participated in performing the
   statistical analysis. F. J. T. obtained the anthropometrical
   characteristics and the written consent of patients. F. C. and M. D. M.
   wrote the paper, and F. C. had primary responsibility for the final
   content.
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NR 32
TC 7
Z9 7
U1 0
U2 6
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1145
EI 1475-2662
J9 BRIT J NUTR
JI Br. J. Nutr.
PD MAR 28
PY 2011
VL 105
IS 6
BP 895
EP 901
DI 10.1017/S0007114510004514
PG 7
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 731SZ
UT WOS:000288131000011
PM 21114893
OA Bronze
DA 2025-06-11
ER

PT J
AU Myhrstad, MCW
   de Mello, VD
   Dahlman, I
   Kolehmainen, M
   Paananen, J
   Rundblad, A
   Carlberg, C
   Olstad, OK
   Pihlajamäki, J
   Holven, KB
   Hermansen, K
   Dragsted, LO
   Gunnarsdottir, I
   Cloetens, L
   Storm, MU
   Åkesson, B
   Rosqvist, F
   Hukkanen, J
   Herzig, KH
   Risérus, U
   Thorsdottir, I
   Poutanen, KS
   Savolainen, MJ
   Schwab, U
   Arner, P
   Uusitupa, M
   Ulven, SM
AF Myhrstad, Mari C. W.
   de Mello, Vanessa D.
   Dahlman, Ingrid
   Kolehmainen, Marjukka
   Paananen, Jussi
   Rundblad, Amanda
   Carlberg, Carsten
   Olstad, Ole Kristoffer
   Pihlajamaki, Jussi
   Holven, Kirsten B.
   Hermansen, Kjeld
   Dragsted, Lars O.
   Gunnarsdottir, Ingibjoerg
   Cloetens, Lieselotte
   Storm, Matilda Ulmius
   Akesson, Bjorn
   Rosqvist, Fredrik
   Hukkanen, Janne
   Herzig, Karl-Heinz
   Riserus, Ulf
   Thorsdottir, Inga
   Poutanen, Kaisa S.
   Savolainen, Markku J.
   Schwab, Ursula
   Arner, Peter
   Uusitupa, Matti
   Ulven, Stine M.
TI Healthy Nordic Diet Modulates the Expression of Genes Related to
   Mitochondrial Function and Immune Response in Peripheral Blood
   Mononuclear Cells from Subjects with Metabolic Syndrome-A SYSDIET
   Sub-Study
SO MOLECULAR NUTRITION & FOOD RESEARCH
LA English
DT Article
DE gene-expression; healthy Nordic diet; metabolic syndrome; peripheral
   blood mononuclear cells; transcriptome
ID POLYUNSATURATED FATTY-ACIDS; OLIVE OIL POLYPHENOLS; MEDITERRANEAN DIET;
   LIFE-STYLE; IN-VIVO; OXIDATIVE STRESS; ADIPOSE-TISSUE; INFLAMMATION;
   SUPPLEMENTATION; DYSFUNCTION
AB Scope To explore the effect of a healthy Nordic diet on the global transcriptome profile in peripheral blood mononuclear cells (PBMCs) of subjects with metabolic syndrome. Methods and results Subjects with metabolic syndrome undergo a 18/24 week randomized intervention study comparing an isocaloric healthy Nordic diet with an average habitual Nordic diet served as control (SYSDIET study). Altogether, 68 participants are included. PBMCs are obtained before and after intervention and total RNA is subjected to global transcriptome analysis. 1302 probe sets are differentially expressed between the diet groups (p-value < 0.05). Twenty-five of these are significantly regulated (FDR q-value < 0.25) and are mainly involved in mitochondrial function, cell growth, and cell adhesion. The list of 1302 regulated probe sets is subjected to functional analyses. Pathways and processes involved in the mitochondrial electron transport chain, immune response, and cell cycle are downregulated in the healthy Nordic diet group. In addition, gene transcripts with common motifs for 42 transcription factors, including NFR1, NFR2, and NF-kappa B, are downregulated in the healthy Nordic diet group. Conclusion These results suggest that benefits of a healthy diet may be mediated by improved mitochondrial function and reduced inflammation.
C1 [Myhrstad, Mari C. W.] Oslo Metropolitan Univ, Fac Hlth Sci, Dept Nursing & Hlth Promot, N-0130 Oslo, Norway.
   [de Mello, Vanessa D.; Kolehmainen, Marjukka; Paananen, Jussi; Pihlajamaki, Jussi; Poutanen, Kaisa S.; Schwab, Ursula; Uusitupa, Matti] Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio 70211, Finland.
   [Dahlman, Ingrid; Arner, Peter] Karolinska Inst, Dept Med H7, S-14186 Stockholm, Sweden.
   [Rundblad, Amanda; Holven, Kirsten B.; Ulven, Stine M.] Univ Oslo, Inst Basic Med Sci, Dept Nutr, N-0316 Oslo, Norway.
   [Carlberg, Carsten] Univ Eastern Finland, Inst Biomed, Kuopio 70211, Finland.
   [Olstad, Ole Kristoffer] Oslo Univ Hosp, Dept Med Biochem, N-0424 Oslo, Norway.
   [Pihlajamaki, Jussi; Schwab, Ursula] Kuopio Univ Hosp, Dept Med Endocrinol & Clin Nutr, Kuopio 70029, Finland.
   [Holven, Kirsten B.] Oslo Univ Hosp, Dept Endocrinol Morbid Obes & Prevent Med, Norwegian Natl Advisory Unit Familial Hypercholes, N-0424 Oslo, Norway.
   [Hermansen, Kjeld] Aarhus Univ Hosp, Dept Endocrinol & Internal Med, DK-8200 Aarhus, Denmark.
   [Dragsted, Lars O.] Univ Copenhagen, Dept Nutr Exercise & Sports, Fac Sci, DK-2200 Copenhagen N, Denmark.
   [Gunnarsdottir, Ingibjoerg; Thorsdottir, Inga] Univ Iceland, Unit Nutr Res, IS-101 Reykjavik, Iceland.
   [Gunnarsdottir, Ingibjoerg; Thorsdottir, Inga] Landspitali Natl Univ Hosp Iceland, IS-101 Reykjavik, Iceland.
   [Cloetens, Lieselotte; Storm, Matilda Ulmius; Akesson, Bjorn] Lund Univ, Biomed Nutr Pure & Appl Biochem, S-22100 Lund, Sweden.
   [Akesson, Bjorn] Skane Univ Hosp, Dept Clin Nutr, S-22100 Lund, Sweden.
   [Rosqvist, Fredrik; Riserus, Ulf] Uppsala Univ, Dept Publ Hlth & Caring Sci, Clin Nutr & Metab, S-75122 Uppsala, Sweden.
   [Hukkanen, Janne; Savolainen, Markku J.] Univ Oulu, Dept Internal Med, Oulu 90014, Finland.
   [Hukkanen, Janne; Savolainen, Markku J.] Univ Oulu, Bioctr Oulu, Oulu 90014, Finland.
   [Hukkanen, Janne; Savolainen, Markku J.] Oulu Univ Hosp, Med Res Ctr, Oulu 90014, Finland.
   [Herzig, Karl-Heinz] Univ Oulu, MRC, Inst Biomed, Oulu 90014, Finland.
   [Herzig, Karl-Heinz] Univ Oulu, MRC, Bioctr Oulu, Oulu 90014, Finland.
   [Herzig, Karl-Heinz] Univ Hosp, Oulu 90014, Finland.
   [Herzig, Karl-Heinz] Poznan Univ Med Sci, Dept Gastroenterol & Metab, PL-1061701 Poznan, Poland.
   [Poutanen, Kaisa S.] VTT Tech Res Ctr Finland, Espoo 02044, Finland.
C3 Oslo Metropolitan University (OsloMet); University of Eastern Finland;
   Karolinska Institutet; University of Oslo; University of Eastern
   Finland; University of Oslo; University of Eastern Finland; University
   of Eastern Finland Hospital; Kuopio University Hospital; University of
   Oslo; Aarhus University; University of Copenhagen; University of
   Iceland; Lund University; Lund University; Skane University Hospital;
   Uppsala University; University of Oulu; University of Oulu; University
   of Oulu; University of Oulu; University of Oulu; Poznan University of
   Medical Sciences; VTT Technical Research Center Finland
RP Myhrstad, MCW (corresponding author), Oslo Metropolitan Univ, Fac Hlth Sci, Dept Nursing & Hlth Promot, N-0130 Oslo, Norway.
EM mari.myhrstad@oslomet.no
RI Rosqvist, Fredrik/K-8975-2019; Gunnarsdottir, Ingibjorg/L-9371-2015;
   Dragsted, Lars/AAT-1713-2020; Myhrstad, Mari/ABE-7132-2021; Kolehmainen,
   Marjukka/JFS-1563-2023; Akesson, Bjorn/Q-9163-2017; Ulven,
   Stine/ABD-7140-2020; hermansen, kjeld/AAY-4241-2021; Uusitupa,
   Matti/AAX-4929-2020; Rundblad, Amanda/AAW-7196-2021; Thorsdottir,
   Inga/M-3260-2015; Hukkanen, Janne/C-7292-2013; Carlberg,
   Carsten/C-9075-2011; Dragsted, Lars Ove/N-3384-2014
OI Rundblad, Amanda/0000-0002-1243-5699; Ulven, Stine/0000-0001-7986-4204;
   Gunnarsdottir, Ingibjorg/0000-0001-9447-8627; Pihlajamaki,
   Jussi/0000-0002-6241-6859; Thorsdottir, Inga/0000-0002-2946-287X;
   Myhrstad, Mari/0000-0003-1982-1792; Dahlman, Ingrid/0000-0003-3819-5977;
   Hukkanen, Janne/0000-0003-4981-0525; Carlberg,
   Carsten/0000-0003-2633-0684; Dragsted, Lars Ove/0000-0003-0609-6317;
   Kolehmainen, Marjukka/0000-0002-3770-2538; Paananen,
   Jussi/0000-0001-5100-4907; Arner, Peter/0000-0002-6208-6220
FU NordForsk Nordic Centre of Excellence in Food, Nutrition and Health
   [070014]; Oslo Metropolitan University-OsloMet (Norway); University of
   Oslo (Norway); Throne Holst Foundation (Norway); Academy of Finland;
   Swedish Research Council; Svenska Diabetesforbundet; SRP Diabetes;
   Finnish Diabetes Research Foundation; Finnish Foundation for
   Cardiovascular Research; Sigrid Juselius Foundation; EVO from Kuopio
   University Hospital (Finland); Druvan Foundation; Skane University
   Hospital; Heart-Lung Foundation; Diabetesfonden and Foundation Cerealia
   (Sweden); Danish Obesity Research Centre (DanORC, ); Danish Council for
   Strategic Research (DairyHealth, BioFunCarb) (Denmark); Agricultural
   Productivity Fund; Research Fund of the University of Iceland (Iceland)
FX The authors thank Dr. Maritta Siloaho for excellent expertise and advice
   for biochemical measurements and Marika Ronnholm for excellent technical
   assistance, and David Brodin for initial normalization of microarray
   data. The project was funded by NordForsk Nordic Centre of Excellence in
   Food, Nutrition and Health project 070014 (SYSDIET [Systems Biology in
   Controlled Dietary Interventions and Cohort Studies]) and further, Oslo
   Metropolitan University-OsloMet (Norway), University of Oslo (Norway),
   Throne Holst Foundation (Norway), Academy of Finland, Swedish Research
   Council, Svenska Diabetesforbundet, SRP Diabetes, Finnish Diabetes
   Research Foundation, Finnish Foundation for Cardiovascular Research, the
   Sigrid Juselius Foundation, EVO funding from Kuopio University Hospital
   (Finland), the Druvan Foundation, Skane University Hospital, the
   Heart-Lung Foundation, Diabetesfonden and Foundation Cerealia (Sweden),
   the Danish Obesity Research Centre (DanORC, ), the Danish Council for
   Strategic Research (DairyHealth, BioFunCarb) (Denmark), the Agricultural
   Productivity Fund, and the Research Fund of the University of Iceland
   (Iceland). M.C.W.M.: planning, conducting statistical analysis
   (bioinformatics), interpretation and reporting of data, writing of the
   manuscript. V.D.M.: planning, interpretation and reporting of data,
   writing of .the manuscript. I.D.: planning, conducting, interpretation,
   and reporting of data; responsibility of transcriptomic analyses
   laboratory; statistical analysis (bioinformatics); critically reviewed
   the manuscript. M.K.: planning, conducting, interpretation, and
   reporting of data; critically reviewed the manuscript. J.Pa.: planning,
   conducting, and reporting statistical analysis (bioinformatics);
   critically reviewed the manuscript. A.R.: conducting and reporting
   statistical analyses, critically reviewed the manuscript. C.C.:
   planning, interpretation of data, critically reviewed the manuscript.
   O.K.O.: conducting and reporting statistical analysis (bioinformatics),
   critically reviewed the manuscript. J.Pi.: planning, interpretation of
   data, critically reviewed the manuscript. K.B.H.: planning,
   interpretation of data, critically reviewed the manuscripts. K.H.:
   planning, conducting, critically reviewed the manuscript. L.O.D.:
   planning, critically reviewed the manuscript. I.G.: planning,
   conducting, critically reviewed the manuscript. L.C.: planning,
   conducting, critically reviewed the manuscript. M.U.S.: planning,
   conducting, critically reviewed the manuscript. B.angstrom.: planning,
   conducting, reporting of data, critically reviewed the manuscript. F.R.:
   planning, conducting, critically reviewed the manuscript. J.H.:
   planning, conducting, critically reviewed the manuscript. K.-H.H.:
   planning, conducting, critically reviewed the manuscript. U.R.:
   planning, conducting, critically reviewed the manuscript. IT: planning,
   conducting, critically reviewed the manuscript. KP: planning,
   conducting, critically reviewed the manuscript. M.J.S.: planning,
   conducting, critically reviewed the manuscript. U.S.: planning,
   responsibility of conducting the intervention, reporting of data,
   critically reviewed the manuscript. P.A.: planning, conducting,
   interpretation and reporting of data, critically reviewed the
   manuscript. M.U.: responsibility of coordination of the consortium;
   planning, funding, conducting, interpretation, and reporting of data;
   critically reviewed the manuscript. S.M.U.: planning, conducting,
   interpretation, and reporting of data; funding, responsibility for
   coordination of PBMC samples, writing of the manuscript.
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NR 59
TC 9
Z9 9
U1 0
U2 15
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1613-4125
EI 1613-4133
J9 MOL NUTR FOOD RES
JI Mol. Nutr. Food Res.
PD JUL
PY 2019
VL 63
IS 13
AR 1801405
DI 10.1002/mnfr.201801405
PG 13
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA IG2YQ
UT WOS:000473667000001
PM 30964598
OA Green Published, Green Accepted
DA 2025-06-11
ER

PT J
AU Nunn, AVW
   Guy, GW
   Bell, JD
AF Nunn, Alistair V. W.
   Guy, Geoffrey W.
   Bell, Jimmy D.
TI Endocannabinoids, FOXO and the metabolic syndrome: Redox, function and
   tipping point - The view from two systems
SO IMMUNOBIOLOGY
LA English
DT Article
DE Endocannabinoid; FOXO; metabolic syndrome; Tipping point; Redox;
   Hormesis; Mitochondria
ID NF-KAPPA-B; ACTIVATED-RECEPTOR-GAMMA; CANNABINOID RECEPTORS; OXIDATIVE
   STRESS; LIFE-SPAN; TRANSCRIPTION FACTORS; CALORIC RESTRICTION;
   GENE-EXPRESSION; ADIPOSE-TISSUE; PROTEIN-KINASE
AB The endocannabinoid system (ECS) was only 'discovered' in the 1990s. Since then, many new ligands have been identified, as well as many new intracellular targets - ranging from the PPARs, to mitochondria, to lipid rafts. It was thought that blocking the CB-1 receptor might reverse obesity and the metabolic syndrome. This was based on the idea that the ECS was dysfunctional in these conditions. This has met with limited success. The reason may be that the ECS is a homeostatic system, which integrates energy seeking and storage behaviour with resistance to oxidative stress. It could be viewed as having thrifty actions. Thriftiness is an innate property of life, which is programmed to a set point by both environment and genetics, resulting in an epigenotype perfectly adapted to its environment. This thrifty set point can be modulated by hormetic stimuli, such as exercise, cold and plant micronutrients. We have proposed that the physiological and protective insulin resistance that underlies thriftiness encapsulates something called 'redox thriftiness', whereby insulin resistance is determined by the ability to resist oxidative stress. Modern man has removed most hormetic stimuli and replaced them with a calorific sedentary lifestyle, leading to increased risk of metabolic inflexibility. We suggest that there is a tipping point where lipotoxicity in adipose and hepatic cells induces mild inflammation, which switches thrifty insulin resistance to inflammation-driven insulin resistance. To understand this, we propose that the metabolic syndrome could be seen from the viewpoint of the ECS, the mitochondrion and the FOXO group of transcription factors. FOX has many thrifty actions, including increasing insulin resistance and appetite, suppressing oxidative stress and shifting the organism towards using fatty acids. In concert with factors such as PGC-1, they also modify mitochondrial function and biogenesis. Hence, the ECS and FOX() may interact at many points: one of which may be via intracellular redox signalling. As cannabinoids have been shown to modulate reactive oxygen species production, it is possible that they can upregulate anti-oxidant defences. This suggests they may have an 'endohormetic' signalling function. The tipping point into the metabolic syndrome may be the result of a chronic lack of hormetic stimuli (in particular, physical activity), and thus, stimulus for PGC-1, with a resultant reduction in mitochondrial function and a reduced lipid capacitance. This, in the context of a positive calorie environment, will result in increased visceral adipose tissue volume, abnormal ectopic fat content and systemic inflammation. This would worsen the inflammatory-driven pathological insulin resistance and inability to deal with lipids. The resultant oxidative stress may therefore drive a compensatory anti-oxidative response epitomised by the ECS and FOXO. Thus, although blocking the ECS (e.g. via rimonabant) may induce temporary weight loss, it may compromise long-term stress resistance. Clues about how to modulate the system more safely are emerging from observations that some polyphenols, such as resveratrol and possibly, some phytocannabinoids, can modulate mitochondrial function and might improve resistance to a modern lifestyle. (C) 2009 Elsevier GmbH. All rights reserved.
C1 [Nunn, Alistair V. W.; Bell, Jimmy D.] Univ London Imperial Coll Sci Technol & Med, Hammersmith Hosp, MRC Clin Sci Ctr, Metab & Mol Imaging Grp, London W12 0HS, England.
   [Guy, Geoffrey W.] GW Pharmaceut, Salisbury SP4 0JQ, Wilts, England.
C3 Imperial College London
RP Nunn, AVW (corresponding author), Univ London Imperial Coll Sci Technol & Med, Hammersmith Hosp, MRC Clin Sci Ctr, Metab & Mol Imaging Grp, Du Cane Rd, London W12 0HS, England.
EM alistair.nunn@btconnect.com; gwg@gwpharm.com; jimmy.bell@csc.mrc.co.uk
RI Nunn, Alistair/ABE-2462-2020
OI Bell, Jimmy/0000-0003-3804-1281
FU MRC [MC_U120061305] Funding Source: UKRI; Medical Research Council
   [MC_U120061305] Funding Source: Medline
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NR 164
TC 13
Z9 16
U1 0
U2 12
PU ELSEVIER GMBH
PI MUNICH
PA HACKERBRUCKE 6, 80335 MUNICH, GERMANY
SN 0171-2985
EI 1878-3279
J9 IMMUNOBIOLOGY
JI Immunobiology
PD AUG
PY 2010
VL 215
IS 8
BP 617
EP 628
DI 10.1016/j.imbio.2009.03.005
PG 12
WC Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology
GA 640JR
UT WOS:000281048000006
PM 19457573
DA 2025-06-11
ER

PT J
AU Stieg, MR
   Sievers, C
   Farr, O
   Stalla, GK
   Mantzoros, CS
AF Stieg, Mareike R.
   Sievers, Caroline
   Farr, Olivia
   Stalla, Guenter K.
   Mantzoros, Christos S.
TI Leptin: A hormone linking activation of neuroendocrine axes with
   neuropathology
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Review
DE Leptin; Neuroendocrine axes; Neuropsychiatric aspects
ID PITUITARY-ADRENAL AXIS; ANOREXIA-NERVOSA; PLASMA LEPTIN; SERUM LEPTIN;
   HIPPOCAMPAL NEUROGENESIS; METABOLIC SYNDROME; ARCUATE NUCLEUS;
   NEUROPEPTIDE-Y; CHRONIC STRESS; IN-VIVO
AB Leptin, a peptide hormone secreted by adipocytes, plays a central role in controlling appetite and weight in both rodents and humans. Basic science and clinical research suggest that this hormone not only affects the regulation of the neuroendocrine axes, but also exerts effects on the central nervous system with subsequent alterations in psychological functions.
   For instance, leptin suppresses cortisol secretion during stress-related activation of the adrenal axis. As psychiatric disorders like depression are associated with hypercortisolism, leptin is proposed to exert anti-depressant-like effects due to its inhibition of chronically overactive hypothalamo-pituitary-adrenal axis function. Moreover, leptin status of depressed patients could serve as a prognostic marker for therapy response.
   Besides its influence on neuroendocrine pathways leptin seems to have direct central effects on brain development and neuroplasticity. Low leptin levels have been shown to be associated with increased risk of developing dementia, supporting the idea of a pro-cognitive effect of leptin. These areas may have direct clinical implications and deserve to be studied further in the future. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Stieg, Mareike R.; Sievers, Caroline; Stalla, Guenter K.] Max Planck Inst Psychiat, D-80804 Munich, Germany.
   [Farr, Olivia; Mantzoros, Christos S.] Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Div Endocrinol Diabet & Metab, Boston, MA 02215 USA.
   [Farr, Olivia; Mantzoros, Christos S.] Boston VA Healthcare Syst, Endocrinol Sect, Boston, MA USA.
C3 Max Planck Society; Harvard University; Harvard Medical School; Harvard
   University Medical Affiliates; Beth Israel Deaconess Medical Center;
   Harvard University; Harvard University Medical Affiliates; US Department
   of Veterans Affairs; Veterans Health Administration (VHA); VA Boston
   Healthcare System
RP Stieg, MR (corresponding author), Max Planck Inst Psychiat, Kreapelinstr 2-10, D-80804 Munich, Germany.
EM mareike_stieg@mpipsykl.mpg.de; cmantzor@bidmc.harvard.edu
RI Mantzoros, Christos/Y-2902-2019; Farr, Olivia/H-6929-2019
OI Stalla, Guenter/0000-0002-1975-3294; Farr, Olivia/0000-0002-5182-3432
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NR 122
TC 63
Z9 64
U1 0
U2 20
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
EI 1873-3360
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD JAN
PY 2015
VL 51
BP 47
EP 57
DI 10.1016/j.psyneuen.2014.09.004
PG 11
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA AY5BI
UT WOS:000347588000005
PM 25290346
DA 2025-06-11
ER

PT J
AU Tuncay, E
   Olgar, Y
   Durak, A
   Degirmenci, S
   Bitirim, CV
   Turan, B
AF Tuncay, Erkan
   Olgar, Yusuf
   Durak, Aysegul
   Degirmenci, Sinan
   Bitirim, Ceylan Verda
   Turan, Belma
TI β3-adrenergic receptor activation plays an important role in
   the depressed myocardial contractility via both elevated levels of
   cellular free Zn<SUP>2+</SUP> and reactive nitrogen species
SO JOURNAL OF CELLULAR PHYSIOLOGY
LA English
DT Article
DE cardiac function; confocal imaging; diabetes; intracellular zinc;
   metabolic syndrome; nitrosative stress
ID PERMEABILITY TRANSITION PORE; NITRIC-OXIDE; FUNCTIONAL
   BETA(3)-ADRENOCEPTOR; REPERFUSION INJURY; HEART; STIMULATION;
   EXPRESSION; ZINC; BETA(2)-ADRENOCEPTORS; CARDIOMYOCYTES
AB Role of (3)-AR dysregulation, as either cardio-conserving or cardio-disrupting mediator, remains unknown yet. Therefore, we examined the molecular mechanism of (3)-AR activation in depressed myocardial contractility using a specific agonist CL316243 or using (3)-AR overexpressed cardiomyocytes. Since it has been previously shown a possible correlation between increased cellular free Zn2+ ([Zn2+](i)) and depressed cardiac contractility, we first demonstrated a relation between (3)-AR activation and increased [Zn2+](i), parallel to the significant depolarization in mitochondrial membrane potential in rat ventricular cardiomyocytes. Furthermore, the increased [Zn2+](i) induced a significant increase in messenger RNA (mRNA) level of (3)-AR in cardiomyocytes. Either (3)-AR activation or its overexpression could increase cellular reactive oxygen species (ROS) and reactive nitrogen species (RNS) levels, in line with significant changes in nitric oxide (NO)-pathway, including increases in the ratios of pNOS3/NOS3 and pGSK-3/GSK-3, and PKG expression level in cardiomyocytes. Although (3)-AR activation induced depression in both Na+- and Ca2+-currents, the prolonged action potential (AP) seems to be associated with a marked depression in K+-currents. The (3)-AR activation caused a negative inotropic effect on the mechanical activity of the heart, through affecting the cellular Ca2+-handling, including its effect on Ca2+-leakage from sarcoplasmic reticulum (SR). Our cellular level data with (3)-AR agonism were supported with the data on high [Zn2+](i) and (3)-AR protein-level in metabolic syndrome (MetS)-rat heart. Overall, our present data can emphasize the important deleterious effect of (3)-AR activation in cardiac remodeling under pathological condition, at least, through a cross-link between (3)-AR activation, NO-signaling, and [Zn2+](i) pathways. Moreover, it is interesting to note that the recovery in ER-stress markers with (3)-AR agonism in hyperglycemic cardiomyocytes is favored. Therefore, how long and to which level the (3)-AR agonism would be friend or become foe remains to be mystery, yet.
C1 [Tuncay, Erkan; Olgar, Yusuf; Durak, Aysegul; Degirmenci, Sinan; Bitirim, Ceylan Verda; Turan, Belma] Ankara Univ, Dept Biophys, Fac Med, TR-06100 Ankara, Turkey.
C3 Ankara University
RP Turan, B (corresponding author), Ankara Univ, Dept Biophys, Fac Med, TR-06100 Ankara, Turkey.
EM belma.turan@medicine.ankara.edu.tr
RI TUNCAY, ERKAN/AAG-8065-2020; olğar, yusuf/I-8960-2016; TURAN,
   Belma/AAG-8084-2020; durak, aysegul/AAA-7647-2022; BITIRIM,
   VERDA/A-6731-2018; Değirmenci, Sinan/M-7694-2013
OI Bitirim, Ceylan Verda/0000-0002-7979-0679; TURAN,
   Belma/0000-0003-2583-9294; TUNCAY, ERKAN/0000-0002-6675-2534; OLGAR,
   YUSUF/0000-0002-3226-7450
FU TUBITAK [SBAG-214S254]
FX TUBITAK, Grant/Award Number: SBAG-214S254
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NR 57
TC 6
Z9 6
U1 0
U2 12
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0021-9541
EI 1097-4652
J9 J CELL PHYSIOL
JI J. Cell. Physiol.
PD AUG
PY 2019
VL 234
IS 8
BP 13370
EP 13386
DI 10.1002/jcp.28015
PG 17
WC Cell Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Physiology
GA HX2SA
UT WOS:000467240800109
PM 30613975
DA 2025-06-11
ER

PT J
AU Wong, MMH
   Chan, KY
   Lo, K
AF Wong, Martin Ming Him
   Chan, Kwan Yi
   Lo, Kenneth
TI Manganese Exposure and Metabolic Syndrome: A Systematic Review and
   Meta-Analysis
SO NUTRIENTS
LA English
DT Article
DE manganese; micronutrient; metal exposure; metabolic syndrome;
   meta-analysis
ID NATIONAL-HEALTH; CARDIOVASCULAR-DISEASE; DIETARY MANGANESE; OXIDATIVE
   STRESS; UNITED-STATES; RISK; ADULTS; ASSOCIATIONS; INFLAMMATION;
   PREVALENCE
AB Manganese (Mn) is an essential element acting as a co-factor of superoxide dismutase, and it is potentially beneficial for cardiometabolic health by reducing oxidative stress. Although some studies have examined the relationship between Mn and metabolic syndrome (MetS), no systematic review and meta-analysis has been presented to summarize the evidence. Therefore, the present review examined the association between dietary and environmental Mn exposure, and MetS risk. A total of nine cross-sectional studies and three case-control studies were included, which assessed Mn from diet, serum, urine, and whole blood. The association of the highest Mn level from diet (three studies, odds ratio (OR): 0.83, 95% confidence interval (C.I.) = 0.57, 1.21), serum (two studies, OR: 0.87, 95% C.I. = 0.66, 1.14), urine (two studies, OR: 0.84, 95% C.I. = 0.59, 1.19), and whole blood (two studies, OR: 0.92, 95% C.I. = 0.53, 1.60) were insignificant, but some included studies have suggested a non-linear relationship of urinary and blood Mn with MetS, and higher dietary Mn may associate with a lower MetS risk in some of the included studies. While more evidence from prospective cohorts is needed, future studies should use novel statistical approaches to evaluate relative contribution of Mn on MetS risk along with other inter-related exposures.
C1 [Wong, Martin Ming Him] Univ Hong Kong, Sch Profess & Continuing Educ, Hong Kong, Peoples R China.
   [Chan, Kwan Yi] Chinese Univ Hong Kong, Sch Publ Hlth & Primary Care, Shatin, Hong Kong, Peoples R China.
   [Lo, Kenneth] Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Kowloon, Hung Hom, 11 Yuk Choi Rd, Hong Kong, Peoples R China.
   [Lo, Kenneth] Hong Kong Polytech Univ, Res Inst Smart Ageing, Hong Kong, Peoples R China.
C3 University of Hong Kong; Chinese University of Hong Kong; Hong Kong
   Polytechnic University; Hong Kong Polytechnic University
RP Lo, K (corresponding author), Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Kowloon, Hung Hom, 11 Yuk Choi Rd, Hong Kong, Peoples R China.; Lo, K (corresponding author), Hong Kong Polytech Univ, Res Inst Smart Ageing, Hong Kong, Peoples R China.
EM martinwong1112@gmail.com; chan11@hotmail.com; khklo@polyu.edu.hk
RI Lo, Kenneth/ABB-6248-2020; , Kenneth/C-6537-2014
OI , Kenneth/0000-0003-4624-2737
FU Funding for Research Institutes [CD69]; Start-up Fund for RAPs under the
   Strategic Hiring Scheme [BD8H]
FX Funding for this work was supported by Funding for Research Institutes
   (Grant number: CD69) and Start-up Fund for RAPs under the Strategic
   Hiring Scheme (Grant number: BD8H).
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NR 45
TC 21
Z9 21
U1 0
U2 11
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD FEB
PY 2022
VL 14
IS 4
AR 825
DI 10.3390/nu14040825
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 2T8WA
UT WOS:000822747300001
PM 35215474
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Monneret, D
   Tamisier, R
   Ducros, V
   Garrel, C
   Levy, P
   Baguet, JP
   Faure, P
   Pépin, JL
AF Monneret, D.
   Tamisier, R.
   Ducros, V.
   Garrel, C.
   Levy, P.
   Baguet, J. P.
   Faure, P.
   Pepin, J. L.
TI The impact of obstructive sleep apnea on homocysteine and carotid
   remodeling in metabolic syndrome
SO RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
LA English
DT Article
DE Homocysteine; Obstructive sleep apnea; Metabolic syndrome; Oxidative
   stress; Plasma thiols; Urinary 15-F-2t-isoprostane; Carotid intima-media
   thickness
ID PLASMA HOMOCYSTEINE; CARDIOVASCULAR-DISEASE; ANTIOXIDANT PROPERTIES;
   SERUM-ALBUMIN; ATHEROSCLEROSIS; ASSOCIATION; IMPAIRMENT; PRESSURE;
   THIOLS
AB Obstructive sleep apnea (OSA) and metabolic syndrome (MetS) are associated with increased cardiovascular morbidity and mortality. Increased homocysteine is suggested as an independent risk factor for atherosclerosis and cardiovascular disease but remains disputed in OSA. We assessed polysomnography, carotid intima-media thickness (CIMT) and biology in 35 MetS patients, according to the presence (OSA + mets: n = 26) or the absence of OSA (mets: is = 9). In OSA + MetS patients, homocysteine levels were increased compared to MetS subjects (12.8 +/- 3.8 vs. 9.5 +/- 2.5 mu mol/L; P = 0.026). In the whole population, homocysteine correlated with apnea-hypopnea index (AHI) (r = 0.522: P = 0.001) and CIMT (r = 0.376; P = 0.026). Homocysteine was negatively correlated with plasma thiols (r = -0.406; P = 0.017) and positively with urinary 15-F2t-isoprostanes (r = 0.347; P = 0.044). Multivariate regression analysis revealed that AHI (beta = 0.559; P < 0.001) and urinary 15-F2t-isoprostane (beta = 0.310; P = 0.018) were independently associated with homocysteine level. We conclude that homocysteine level was higher in MetS when associated with OSA and proportional to OSA severity. In this context, vascular remodeling appeared more severe and mediated by oxidative stress. (C) 2011 Elsevier B.V. All rights reserved.
C1 [Tamisier, R.; Levy, P.; Pepin, J. L.] Univ Hosp, Sleep Lab, EFCR, F-38043 Grenoble 09, France.
   [Monneret, D.; Tamisier, R.; Levy, P.; Faure, P.; Pepin, J. L.] Univ Grenoble 1, INSERM, Lab Hypoxia & Pathophysiol U1042 HP2, Grenoble, France.
   [Monneret, D.; Ducros, V.; Garrel, C.; Faure, P.] Univ Hosp, Dept Biochem Toxicol & Pharmacol, F-38043 Grenoble 09, France.
   [Baguet, J. P.] Univ Hosp, Dept Cardiol, F-38043 Grenoble 09, France.
C3 CHU Grenoble Alpes; Institut National de la Sante et de la Recherche
   Medicale (Inserm); Communaute Universite Grenoble Alpes; Universite
   Grenoble Alpes (UGA); CHU Grenoble Alpes; CHU Grenoble Alpes
RP Pépin, JL (corresponding author), Univ Hosp, Sleep Lab, EFCR, BP 217, F-38043 Grenoble 09, France.
EM JPepin@chu-grenoble.fr
RI LEVY, Patrick/AAX-2802-2020; PEPIN, Jean-Louis/M-6549-2014; Baguet,
   Jean-Philippe/M-5536-2014; Tamisier, Renaud/M-6858-2014; Monneret,
   Denis/AFF-3297-2022
OI Pepin, Jean Louis/0000-0003-3832-2358; Tamisier,
   Renaud/0000-0003-1128-6529; Monneret, Denis/0000-0002-6491-0607; Levy,
   Patrick/0000-0003-3174-7935
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NR 32
TC 28
Z9 30
U1 0
U2 8
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1569-9048
EI 1878-1519
J9 RESP PHYSIOL NEUROBI
JI Respir. Physiol. Neuro.
PD MAR 15
PY 2012
VL 180
IS 2-3
BP 298
EP 304
DI 10.1016/j.resp.2011.12.009
PG 7
WC Physiology; Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Physiology; Respiratory System
GA 902CM
UT WOS:000301016200021
PM 22210465
DA 2025-06-11
ER

PT J
AU Sarafidis, PA
   Bakris, GL
AF Sarafidis, P. A.
   Bakris, G. L.
TI Non-esterified fatty acids and blood pressure elevation: a mechanism for
   hypertension in subjects with obesity/insulin resistance?
SO JOURNAL OF HUMAN HYPERTENSION
LA English
DT Review
DE non-esterified fatty acids; hypertension; obesity; insulin resistance;
   type II diabetes
ID SYMPATHETIC-NERVOUS-SYSTEM; NITRIC-OXIDE; OLEIC-ACID;
   INSULIN-RESISTANCE; ANGIOTENSIN-II; ACUTE HYPERLIPIDEMIA; METABOLIC
   SYNDROME; OXIDATIVE STRESS; GROWTH-FACTOR; RISK-FACTOR
AB The prevalence of hypertension in individuals with obesity or type II diabetes is substantially elevated. Increased levels of non-esterified fatty acids (NEFAs) in abdominally obese subjects were reported to contribute in the development of various disturbances related to the metabolic syndrome, such as hepatic and peripheral insulin resistance (IR), dyslipidaemia, beta-cell apoptosis, endothelial dysfunction and others. However, the involvement of NEFAs in the development of hypertension has been much less studied in comparison to other mechanisms linking IR and central obesity with blood pressure ( BP) elevation. This article reviews the existing evidence on the relation between NEFA and hypertension in an attempt to shed a light on it. In vivo data from both animal and human studies support that acute plasma NEFA elevation leads to increase in BP levels, whereas epidemiological evidence suggests a link between increased NEFA levels and hypertension. Further, accumulating data indicate the existence of several pathways through which NEFAs could promote BP elevation, that is alpha(1)-adrenergic stimulation, endothelial dysfunction, increase in oxidant stress, stimulation of vascular cell's growth and others. The above data support a possible important role of NEFA in hypertension development in patients with obesity and the metabolic syndrome and raise hypotheses for future research.
C1 Rush Univ, Med Ctr, Hypertens Clin Res Ctr, Dept Prevent Med, Chicago, IL 60612 USA.
C3 Rush University
RP Sarafidis, PA (corresponding author), Rush Univ, Med Ctr, Hypertens Clin Res Ctr, Dept Prevent Med, 1700 W Van Buren,Suite 470, Chicago, IL 60612 USA.
EM psarafidis11@yahoo.gr
RI Sarafidis, Pantelis/AFO-2131-2022; Butko, Olena/HDN-3484-2022
OI Sarafidis, Pantelis/0000-0002-9174-4018
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NR 69
TC 75
Z9 85
U1 0
U2 19
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0950-9240
EI 1476-5527
J9 J HUM HYPERTENS
JI J. Hum. Hypertens.
PD JAN
PY 2007
VL 21
IS 1
BP 12
EP 19
DI 10.1038/sj.jhh.1002103
PG 8
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 117RI
UT WOS:000242890200004
PM 17051236
DA 2025-06-11
ER

PT J
AU Shin, CN
   Soltero, E
   Mama, SK
   Sunseri, C
   Lee, RE
AF Shin, Cha-Nam
   Soltero, Erica
   Mama, Scherezade K.
   Sunseri, Christopher
   Lee, Rebecca E.
TI Association of Discrimination and Stress With Cardiometabolic Risk
   Factors in Ethnic Minority Women
SO CLINICAL NURSING RESEARCH
LA English
DT Article; Proceedings Paper
CT 4th U.S.-Sino Forum
CY JUN 04-06, 2017
CL Univ Pittsburgh, Pittsburgh, PA
HO Univ Pittsburgh
DE discrimination; stress; coping; minority health; women
ID BODY-MASS INDEX; SELF-REPORTED EXPERIENCES; DIURNAL CORTISOL RHYTHMS;
   RACIAL-DISCRIMINATION; AFRICAN-AMERICAN; PERCEIVED DISCRIMINATION;
   BLOOD-PRESSURE; HEALTH; HYPERTENSION; CONSEQUENCES
AB Psychological stressors can contribute to adverse health outcomes and lead to health disparities. To examine associations among psychological stressors, coping, blood pressure, body mass index, and body fat in ethnic minority women, we conducted a secondary analysis using data from 178 African American and Hispanic/Latina women who completed measures of perceived racial discrimination and stress, coping, blood pressure, and body composition. The mean age of participants was 45.3 (+/- 9.3 years), and most were obese (74.2%) and had prehypertensive systolic blood pressure (125.7 +/- 14.6 mmHg). Hierarchical multiple regression models indicated a significant negative relationship between racial discrimination and percent body fat, and positive associations between stress and blood pressure. Coping did not moderate the association between racial discrimination and blood pressure or body composition. Health care providers should consider psychological stressors as underlying causes for hypertension and address tailored stress-reduction coping strategies when treating African American and Hispanic/Latina women with hypertension.
C1 [Shin, Cha-Nam] Arizona State Univ, Coll Nursing & Hlth Innovat, 500 N 3rd St, Phoenix, AZ 85004 USA.
   [Soltero, Erica; Lee, Rebecca E.] Arizona State Univ, Coll Nursing & Hlth Innovat, Ctr Hlth Promot & Dis Prevent, Phoenix, AZ USA.
   [Mama, Scherezade K.] Penn State Univ, Dept Kinesiol, University Pk, PA 16802 USA.
   [Sunseri, Christopher] Univ Houston, Hlth & Human Performance, Houston, TX USA.
C3 Arizona State University; Arizona State University-Downtown Phoenix;
   Arizona State University; Arizona State University-Downtown Phoenix;
   Pennsylvania Commonwealth System of Higher Education (PCSHE);
   Pennsylvania State University; Pennsylvania State University -
   University Park; Penn State Behrend; University of Houston System;
   University of Houston
RP Shin, CN (corresponding author), Arizona State Univ, Coll Nursing & Hlth Innovat, 500 N 3rd St, Phoenix, AZ 85004 USA.
EM Cha-Nam.Shin@asu.edu
RI Soltero, Erica/GNP-7555-2022
OI Soltero, Erica/0000-0002-7202-9262
FU National Institutes of Health's National Cancer Institute [1R01CA109403]
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: This study
   was funded by a research grant awarded to Dr. Rebecca E. Lee at the
   University of Houston by the National Institutes of Health's National
   Cancer Institute (1R01CA109403).
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NR 49
TC 16
Z9 19
U1 1
U2 7
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1054-7738
EI 1552-3799
J9 CLIN NURS RES
JI Clin. Nurs. Res.
PD DEC
PY 2017
VL 26
IS 6
BP 694
EP 712
DI 10.1177/1054773816669448
PG 19
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI); Conference Proceedings Citation Index - Social Science &amp; Humanities (CPCI-SSH); Conference Proceedings Citation Index - Science (CPCI-S)
SC Nursing
GA FL7CN
UT WOS:000414404000003
PM 27625035
DA 2025-06-11
ER

PT J
AU Unger, AL
   Torres-Gonzalez, M
   Kraft, J
AF Unger, Allison L.
   Torres-Gonzalez, Moises
   Kraft, Jana
TI Dairy Fat Consumption and the Risk of Metabolic Syndrome: An Examination
   of the Saturated Fatty Acids in Dairy
SO NUTRIENTS
LA English
DT Review
DE abdominal obesity; branched-chain fatty acids; cardiometabolic;
   dyslipidemia; hyperglycemia; hypertension; insulin resistance;
   medium-chain fatty acids; odd-chain fatty acids; short-chain fatty acids
ID PROTEIN-COUPLED RECEPTORS; DIET-INDUCED OBESITY; BETA-CELL FUNCTION;
   MYRISTIC ACID; STEARIC-ACID; ADIPOSE-TISSUE; INSULIN-RESISTANCE;
   ABDOMINAL OBESITY; OXIDATIVE STRESS; BODY-COMPOSITION
AB Lifestyle is a key modifiable risk factor involved in the manifestation of metabolic syndrome and, in particular, diet plays a pivotal role in its prevention and development. Current dietary guidelines discourage the consumption of saturated fat and dietary sources rich in saturated fat, such as dairy products, despite data suggesting that full-fat dairy consumption is protective against metabolic syndrome. This narrative review assessed the recent epidemiological and clinical research that examined the consumption of dairy-derived saturated fatty acids (SFA) on metabolic syndrome risk. In addition, this review evaluated studies of individual SFA to gain insight into the potential mechanisms at play with intake of a diet enriched with these dairy-derived fatty acids. This work underscores that SFA are a heterogenous class of fatty acids that can differ considerably in their biological activity within the body depending on their length and specific chemical structure. In summary, previous work on the impact of dairy-derived SFA consumption on disease risk suggests that there is currently insufficient evidence to support current dietary guidelines which consolidate all dietary SFA into a single group of nutrients whose consumption should be reduced, regardless of dietary source, food matrix, and composition.
C1 [Unger, Allison L.; Kraft, Jana] Univ Vermont, Dept Anim & Vet Sci, Burlington, VT 05405 USA.
   [Torres-Gonzalez, Moises] Natl Dairy Council, Rosemont, IL 60018 USA.
   [Kraft, Jana] Univ Vermont, Dept Med, Div Endocrinol Metab & Diabet, Colchester, VT 05446 USA.
C3 University of Vermont; University of Vermont
RP Torres-Gonzalez, M (corresponding author), Natl Dairy Council, Rosemont, IL 60018 USA.
EM Allison.Unger@uvm.edu; Moises.Torres-Gonzalez@dairy.org;
   Jana.Kraft@uvm.edu
OI Unger, Allison/0000-0001-5821-7534
FU National Dairy Council [2977]
FX The work involved for this manuscript was funded by National Dairy
   Council (Grant number 2977 and provided to J.K.).
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NR 119
TC 60
Z9 64
U1 1
U2 13
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD SEP
PY 2019
VL 11
IS 9
AR 2200
DI 10.3390/nu11092200
PG 21
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA JA6PP
UT WOS:000487964600059
PM 31547352
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Di Lorenzo, C
   Dell'Agli, M
   Colombo, E
   Sangiovanni, E
   Restani, P
AF Di Lorenzo, Chiara
   Dell'Agli, Mario
   Colombo, Elisa
   Sangiovanni, Enrico
   Restani, Patrizia
TI Metabolic Syndrome and Inflammation: A Critical Review of In
   Vitro and Clinical Approaches for Benefit Assessment of Plant Food
   Supplements
SO EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Review
ID ALPHA-MEDIATED INFLAMMATION; CARDIOVASCULAR RISK-FACTORS; TYPE-2
   DIABETES-MELLITUS; GREEN TEA CONSUMPTION; C-REACTIVE PROTEIN;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; POLYMORPHONUCLEAR LEUKOCYTES;
   ENDOTHELIAL FUNCTION; LIPID-PEROXIDATION
AB Metabolic syndrome is defined as the clustering in an individual of several metabolic abnormalities associated with insulin resistance, type 2 diabetes, and obesity, in which low-grade chronic inflammatory activity is commonly observed. Part of the European Project PlantLIBRA is concerned with methods to assess the benefits of plant food supplements (PFSs) in countering inflammatory activity and metabolic syndrome. This paper summarizes the current methods used for benefit assessment of PFS, taking into consideration only in vitro, in silico, and clinical methodologies used to investigate the anti-inflammatory properties of plants. No in silico studies (using computer simulation) related to metabolic syndrome were found; these methods appear to be used exclusively for identifying or testing potentially effective compounds in drug development. Most in vitro methods for the assessment of beneficial effects of botanicals or plant food supplements in diabetes were based on a quantitative polymerase chain reaction (PCR), whereas the preferred kind of clinical study was the double-blind randomized controlled clinical trial. Only two parameters were observed to change after treatment with botanicals in both in vitro and in vivo studies: interleukin-6 and tumour necrosis factor-alpha, and these biomarkers should be carefully considered in future studies for PFS benefit assessment.
C1 [Di Lorenzo, Chiara; Dell'Agli, Mario; Colombo, Elisa; Sangiovanni, Enrico; Restani, Patrizia] Univ Milan, Dipartimento Sci Farmacol & Biomol, I-20133 Milan, Italy.
C3 University of Milan
RP Dell'Agli, M (corresponding author), Univ Milan, Dipartimento Sci Farmacol & Biomol, Via Balzaretti 9, I-20133 Milan, Italy.
EM mario.dellagli@unimi.it
RI Colombo, Elisa/AGB-7523-2022; Mario, Dellagli/E-5253-2011
OI Colombo, Elisa/0000-0003-0822-4589; SANGIOVANNI,
   ENRICO/0000-0003-2811-8628; Dell'Agli, Mario/0000-0001-5378-402X
FU European Community [245199]; FSE, Regione Lombardia
FX The writing of this paper was funded by the European Community's Seventh
   Framework Programme under Grant agreement no. 245199. It has been
   carried out within the PlantLIBRA project (website:
   http://www.plantlibra.eu). This paper does not necessarily reflect the
   Commission views of its future policy on this area. The fellowship of
   Elisa Colombo is partially funded by FSE, Regione Lombardia.
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NR 56
TC 17
Z9 20
U1 1
U2 24
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1741-427X
EI 1741-4288
J9 EVID-BASED COMPL ALT
JI Evid.-based Complement Altern. Med.
PY 2013
VL 2013
AR 782461
DI 10.1155/2013/782461
PG 10
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA 103IX
UT WOS:000315910600001
PM 23533519
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Schroeder, M
   Drori, Y
   Ben-Efraim, YJ
   Chen, A
AF Schroeder, Mariana
   Drori, Yonat
   Ben-Efraim, Yair J.
   Chen, Alon
TI Hypothalamic miR-219 regulates individual metabolic differences in
   response to diet-induced weight cycling
SO MOLECULAR METABOLISM
LA English
DT Article
DE Weight cycling; Metabolic syndrome; miRNAs; Ventromedial hypothalamus;
   High fat diet; Diabetes
ID 5-HT1A RECEPTOR; BODY-COMPOSITION; EXPRESSION; GENE; HOMEOSTASIS;
   REPRESSOR; NEURONS; OBESITY; STRESS; LEPTIN
AB Consumption of a low calorie diet is the most common approach to lose weight. While generally effective at first, it is frequently followed by a relapse where the pre-diet weight is regained, and often exceeded. This pattern of repeated weight loss/regain is referred to as weight cycling and the resulting metabolic response varies greatly between individuals.
   Objective: We attempted to address the issue of individual differences in the response to weight cycling in male mice.
   Methods: We first exposed adult wild type mice to repeated cycles of high/low fat food. Next, using a lentiviral approach, we knocked-down or over-expressed miR-219 in the ventromedial hypothalamus (VMH) of an additional mouse cohort and performed a full metabolic assessment.
   Results: Exposure of wild type males to weight cycling resulted in the division of the cohort into subsets of resistant versus metabolic syndrome-prone (MS) animals, which differed in their metabolic profile and hypothalamic miR-219 levels. Lentiviral knock-down of miR-219 in the VMH led to exacerbation of metabolic syndrome. In contrast, over-expression of miR-219 resulted in moderation of the metabolic syndrome phenotype.
   Conclusions: Our results suggest a role for miR-219 in the mediation of the metabolic phenotype resulting from repeated weight cycling. (C) 2018 The Authors. Published by Elsevier GmbH.
C1 [Schroeder, Mariana; Drori, Yonat; Ben-Efraim, Yair J.; Chen, Alon] Weizmann Inst Sci, Dept Neurobiol, IL-76100 Rehovot, Israel.
   [Schroeder, Mariana; Drori, Yonat; Ben-Efraim, Yair J.; Chen, Alon] Max Planck Inst Psychiat, Dept Stress Neurobiol & Neurogenet, D-80804 Munich, Germany.
C3 Weizmann Institute of Science; Max Planck Society
RP Chen, A (corresponding author), Weizmann Inst Sci, Dept Neurobiol, IL-76100 Rehovot, Israel.; Schroeder, M (corresponding author), Max Planck Inst Psychiat, Dept Stress Neurobiol & Neurogenet, D-80804 Munich, Germany.
EM schatzyo@gmail.com; alon.chen@weizmann.ac.il
RI Schroeder, Mariana/AAA-9216-2020
OI Schroeder, Mariana/0000-0002-9517-4243; Chen, Alon/0000-0003-3625-8233
FU European Research Council [260463]; Israel Science Foundation [1565/15,
   1916/12]; Chief Scientist Office of the Israeli Ministry of Health
   [311389]; Federal Ministry of Education and Research [01KU1501A]; I-CORE
   Program of the Planning and Budgeting Committee; Nella and Leon Benoziyo
   Center for Neurological Diseases; Henry Chanoch Krenter Institute for
   Biomedical Imaging and Genomics; Perlman Family Foundation; Adelis
   Foundation; Marc Besen and the Pratt Foundation; Irving I. Moskowitz
   Foundation; Bruno and Simone Licht
FX A.C. is the head of the Max Planck Society-Weizmann Institute of Science
   Laboratory for Experimental Neuropsychiatry and Behavioral
   Neurogenetics. This work is supported by: an FP7 Grant from the European
   Research Council (260463, A.C.); a research grant from the Israel
   Science Foundation (1565/15, A.C.); the ERANET Program, supported by the
   Chief Scientist Office of the Israeli Ministry of Health (311389, A.C.);
   the project was funded by the Federal Ministry of Education and Research
   under the funding code 01KU1501A (A.C.); research support from Roberto
   and Renata Ruhman (A.C.); research support from Bruno and Simone Licht;
   I-CORE Program of the Planning and Budgeting Committee and The Israel
   Science Foundation (grant no. 1916/12 to A.C.); the Nella and Leon
   Benoziyo Center for Neurological Diseases (A.C.); the Henry Chanoch
   Krenter Institute for Biomedical Imaging and Genomics (A.C.); the
   Perlman Family Foundation, founded by Louis L. and Anita M. Perlman
   (A.C.); the Adelis Foundation (A.C.); the Marc Besen and the Pratt
   Foundation (A.C.); and the Irving I. Moskowitz Foundation (A.C.). We
   thank Mr. Sharon Ovadia for his devoted assistance with animal care.
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NR 44
TC 9
Z9 11
U1 0
U2 6
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2212-8778
J9 MOL METAB
JI Mol. Metab.
PD MAR
PY 2018
VL 9
BP 176
EP 186
DI 10.1016/j.molmet.2018.01.015
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA GB5ED
UT WOS:000429085000015
PM 29398616
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Nourbakhsh, M
   Sharifi, R
   Ghorbanhosseini, SS
   Javad, A
   Ahmadpour, F
   Azar, MR
   Larijani, B
AF Nourbakhsh, Mitra
   Sharifi, Roya
   Ghorbanhosseini, Seyedeh Sara
   Javad, Ali
   Ahmadpour, Fatemeh
   Azar, Maryam Razzaghy
   Larijani, Bagher
TI Evaluation of Plasma TRB3 and Sestrin 2 Levels in Obese and
   Normal-Weight Children
SO CHILDHOOD OBESITY
LA English
DT Article
DE obesity; pediatric obesity; sestrin 2; TRB3
ID FUNCTIONAL Q84R POLYMORPHISM; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   TRIBBLES HOMOLOG; LIVER; STRESS; EXPRESSION; RISK; REGENERATION;
   HOMEOSTASIS
AB Objective: Obesity in childhood and adolescence is associated with metabolic syndrome and cardiovascular diseases. TRB3 (Tribbles homolog 3) and sestrin 2 are two newly found proteins that have been identified to play an important role in obesity and its complications.
   Aim: The purpose of this study was to evaluate concentrations of TRB3 and sestrin 2 in plasma of obese and normal-weight children and adolescents, and their association with metabolic and anthropometric parameters. Methods: Plasma levels of TRB3, sestrin 2, insulin, fasting plasma glucose (FPG), and lipid profile were evaluated in 70 children and adolescents (34 obese and 36 controls). Insulin resistance was calculated using a homeostasis model assessment of insulin resistance. Metabolic syndrome was defined according to IDF criteria.
   Results: Plasma TRB3 levels of the obese subjects were significantly higher than that of normal weight subjects. TRB3 levels were positively correlated with BMI, BMI z-score, waist circumference, and FPG. The concentration of sestrin 2 was significantly lower in obese subjects compared to normal-weight subjects. A statistically significant positive correlation was observed between plasma concentrations of sestrin 2 and high-density lipoprotein cholesterol. Neither TRB3 nor sestrin 2 were correlated with insulin resistance and metabolic syndrome.
   Conclusion: Both TRB3 and sestrin 2 may contribute to the development of obesity and its complications and can be considered interesting therapeutic target for the treatment of obesity.
C1 [Nourbakhsh, Mitra; Ghorbanhosseini, Seyedeh Sara] Iran Univ Med Sci, Dept Biochem, Fac Med, Tehran, Iran.
   [Nourbakhsh, Mitra; Javad, Ali; Azar, Maryam Razzaghy] Univ Tehran Med Sci, Endocrinol & Metab Mol Cellular Sci Inst, Metab Disorders Res Ctr, Tehran, Iran.
   [Sharifi, Roya] Iran Univ Med Sci, Sch Allied Med Sci, Dept Med Lab Sci, Tehran 1449614535, Iran.
   [Ahmadpour, Fatemeh] Ahwaz Jundishapor Univ Med Sci, Dept Biochem, Fac Med, Ahvaz, Iran.
   [Azar, Maryam Razzaghy] Iran Univ Med Sci, H Aliasghar Childrens Hosp, Tehran, Iran.
   [Larijani, Bagher] Univ Tehran Med Sci, Endocrinol & Metab Res Ctr, Endocrinol & Metab Clin Sci Inst, Tehran, Iran.
C3 Iran University of Medical Sciences; Tehran University of Medical
   Sciences; Iran University of Medical Sciences; Iran University of
   Medical Sciences; Tehran University of Medical Sciences
RP Sharifi, R (corresponding author), Iran Univ Med Sci, Sch Allied Med Sci, Dept Med Lab Sci, Tehran 1449614535, Iran.
EM sharifi.r@iums.ac.ir
RI Nourbakhsh, Mitra/D-5214-2018; Ahmadpour, Fatemeh/ITV-1197-2023;
   larijani, Bagher/ABE-3315-2020; Razzaghy-Azar, Maryam/E-4968-2011
OI Ghorbanhosseini, Seyedeh sara/0000-0002-1530-2955
FU Endocrinology and Metabolism Research Institute; Tehran University of
   Medical Sciences [1393-02104-1831]
FX This study was financially supported by a grant from Endocrinology and
   Metabolism Research Institute, Tehran University of Medical Sciences
   (grant number 1393-02104-1831).
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NR 45
TC 26
Z9 28
U1 0
U2 8
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 2153-2168
EI 2153-2176
J9 CHILD OBES
JI Child Obes.
PD OCT
PY 2017
VL 13
IS 5
BP 409
EP 414
DI 10.1089/chi.2017.0082
PG 6
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA FI1SX
UT WOS:000411715600008
PM 28639842
DA 2025-06-11
ER

PT J
AU Casariu, ED
   Virgolici, B
   Lixandru, D
   Miricescu, D
   Totan, A
   Popescu, LA
   Mohora, M
AF Casariu, Elena Daniela
   Virgolici, Bogdana
   Lixandru, Daniela
   Miricescu, Daniela
   Totan, Alexandra
   Popescu, Laura Anca
   Mohora, Maria
TI SEA BUCKTHORN PULP OIL TREATMENT CAN PREVENT METABOLIC SYNDROME IN
   HYPERTRIGLYCERIDEMIC WAIST FENOTYPE OBESE CHILDREN
SO FARMACIA
LA English
DT Article
DE childhood obesity; metabolic syndrome; sea buckthorn
ID ENDOTHELIAL DYSFUNCTION; INSULIN-RESISTANCE; OXIDATIVE STRESS;
   ADOLESCENTS; LEPTIN; ATHEROSCLEROSIS; ASSOCIATION; ADIPONECTIN; MARKERS
AB The aim of this study was to determine the effects of Sea Buckthorn pulp oil intake (800 mg/day, 60 days) in hypertriglyceridemic waist phenotype obese children.
   Forty one obese children (10-18 years old) and thirty controls were involved. Modified ATP III (Adult Treatment Panel III) cut points for serum triglycerides (>= 110 mg/dL) and waist circumference (>= 90th percentile for age and sex) were used to divide obese children. Hypertriglyceridemic waist fenotype (n=17) and obese nonhypertriglyceridemic (n=24) obese groups were formed. Metabolic and inflammatory parameters were measured before and after sea buckthorn terapy.
   Metabolic syndrome was present in 14.25% obese children and all these subjects were from hypertriglyceridemic waist fenotype group. Comparing the obese groups, in hypertriglyceridemic waist fenotype obese children, the values for triglycerides (p<0.001), uric acid (p<0.004), C peptide (p<0.04), leptin (p<0.04), alanine aminotransferase (ALT) (p<0.05) and waist circumference (p<0.02), were increased, while high density lipoprotein-cholesterol (HDL-C) (p<0.01) was decreased. After treatment, triglycerides, blood pressure, leptin, C peptide and ceruloplasmin were decreased, while albumin was increased.
   In conclusion, in hypertriglyceridemic waist phenotype obese children, sea buckthorn pulp oil terapy (800mg/day, 60 days) prevents metabolic syndrome, by reducing triglyceridemia and blood pressure. Also, the treatment has a weak antiinflammatory effect.
C1 [Casariu, Elena Daniela] Carol Davila Univ Med & Pharm, Bucharest, Romania.
   [Virgolici, Bogdana; Lixandru, Daniela; Popescu, Laura Anca; Mohora, Maria] Carol Davila Univ Med & Pharm, Dept Funct Sci, Bucharest, Romania.
   [Miricescu, Daniela; Totan, Alexandra] Carol Davila Univ Med & Pharm, Biochenistry Dept, Bucharest, Romania.
C3 Carol Davila University of Medicine & Pharmacy; Carol Davila University
   of Medicine & Pharmacy; Carol Davila University of Medicine & Pharmacy
RP Virgolici, B (corresponding author), Carol Davila Univ Med & Pharm, Dept Funct Sci, Bucharest, Romania.
EM hvirgolici@yahoo.com
RI Virgolici, Bogdana/MTF-9331-2025; Daniela, Miricescu/G-8788-2016;
   Lixandru, Daniela/U-4330-2017; Ripszky-Totan, Alexandra/JTT-4320-2023
OI Ripszky, Alexandra/0000-0002-4345-282X
FU European Social Fund [POSDRU/89/1.5/S/60746];  [POSDRU/107/1.5/S/82839]
FX Bogdana Virgolici, the corresponding author (hvirgolici@yahoo.com) and
   Daniela Lixandru acknowledge the postdoctoral program
   POSDRU/89/1.5/S/60746, from European Social Fund. Laura Anca Popescu
   acknowledges the doctoral program POSDRU/107/1.5/S/82839.
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NR 20
TC 4
Z9 4
U1 1
U2 12
PU SOC STIINTE FARMACEUTICE ROMANIA
PI BUCURESTI
PA BUCURESTI, STR TRAIAN VUIA 6, SECT 1, BUCURESTI, 020956, ROMANIA
SN 0014-8237
EI 2065-0019
J9 FARMACIA
JI Farmacia
PD NOV-DEC
PY 2013
VL 61
IS 6
BP 1043
EP 1053
PG 11
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 276AE
UT WOS:000328719700002
DA 2025-06-11
ER

PT J
AU Gutierrez-Colina, AM
   Aichele, S
   Lavender, JM
   Sanchez, N
   Thorstad, I
   Gulley, LD
   Emerick, JE
   Schrag, R
   Thomas, V
   Spinner, H
   Arnold, T
   Heroy, A
   Haigney, MC
   Tanofsky-Kraff, M
   Shomaker, LB
AF Gutierrez-Colina, Ana M.
   Aichele, Stephen
   Lavender, Jason M.
   Sanchez, Natalia
   Thorstad, Isabel
   Gulley, Lauren D.
   Emerick, Jill E.
   Schrag, Ruby
   Thomas, Victoria
   Spinner, Holly
   Arnold, Thomas
   Heroy, Andrew
   Haigney, Mark C.
   Tanofsky-Kraff, Marian
   Shomaker, Lauren B.
TI Associations of social and cognitive-behavioral variables with
   disinhibited eating and anxiety: An ecological momentary assessment
   study
SO INTERNATIONAL JOURNAL OF EATING DISORDERS
LA English
DT Article
DE adolescent; anxiety; cognitive-behavioral; disinhibited eating;
   ecological momentary assessment; high body weight; interpersonal
ID RANDOMIZED CONTROLLED-TRIAL; METABOLIC SYNDROME; WEIGHT-GAIN; FOLLOW-UP;
   HIGH-RISK; ADOLESCENTS; VALIDATION; OVERWEIGHT; DISORDERS; CHILDREN
AB ObjectiveAmong adolescents, disinhibited eating and anxiety commonly co-occur. Precision intervention approaches targeting unique mechanistic vulnerabilities that contribute to disinhibited eating and anxiety may therefore be helpful. However, the effectiveness of such interventions hinges on knowledge of between- and within-person associations related to disinhibited eating, anxiety, and related processes.MethodA sample of 39 adolescent females (12-17 years) with elevated anxiety and above-average weight (BMI %ile >= 75th) completed measures of theoretically driven social and cognitive-behavioral variables, disinhibited eating, and anxiety via ecological momentary assessment over 7 days. Data were analyzed using mixed-effects models.ResultsBetween-person differences in social stressors were linked to emotional eating, eating in the absence of hunger, and anxiety, whereas between-person differences in negative thoughts were associated with all disinhibited eating variables and anxiety. Between-person differences in avoidance were not related to any outcome. Additionally, between-person differences in social stressors and negative thoughts-as well as within-person deviations (from person-average levels) of social stressors, negative thoughts, and avoidance-were associated with anxiety. In turn, between-person differences in anxiety predicted eating in the absence of hunger and emotional eating, and within-person deviations in anxiety were associated with emotional eating at any given time point.DiscussionFindings support elements of both the interpersonal and cognitive-behavioral models of disinhibited eating. Differential trigger effects on anxiety, both at the between- and within-person levels, and significant associations between anxiety and all eating-related outcomes, highlight the potential utility of interventions targeting individual differences in sensitivity to anxiety triggers.Public SignificanceFindings provide support for the interpersonal and cognitive-behavioral models of disinhibited eating, highlighting anxiety as a salient vulnerability and potential mechanistic factor underlying disinhibited eating. Social, cognitive, and behavioral variables were differentially related to anxiety across participants, suggesting potential for future intervention tailoring and intervention selection based on adolescents' sensitivity to anxiety as a trigger for disinhibited eating behavior.
C1 [Gutierrez-Colina, Ana M.; Aichele, Stephen; Sanchez, Natalia; Gulley, Lauren D.; Shomaker, Lauren B.] Colorado State Univ, Dept Human Dev & Family Studies, Ft Collins, CO 80523 USA.
   [Gutierrez-Colina, Ana M.; Gulley, Lauren D.; Shomaker, Lauren B.] Univ Colorado Anschutz, Dept Pediat, Sect Endocrinol, Aurora, CO USA.
   [Gutierrez-Colina, Ana M.; Gulley, Lauren D.; Shomaker, Lauren B.] Childrens Hosp Colorado, Aurora, CO USA.
   [Aichele, Stephen; Shomaker, Lauren B.] Colorado Sch Publ Hlth, Aurora, CO USA.
   [Lavender, Jason M.; Thorstad, Isabel; Schrag, Ruby; Thomas, Victoria; Spinner, Holly; Arnold, Thomas; Heroy, Andrew; Haigney, Mark C.; Tanofsky-Kraff, Marian] Uniformed Serv Univ Hlth Sci, Dept Med, Mil Cardiovasc Outcomes Res MiCOR Program, Bethesda, MD USA.
   [Lavender, Jason M.; Thorstad, Isabel; Schrag, Ruby; Thomas, Victoria; Spinner, Holly; Arnold, Thomas; Heroy, Andrew] Metis Fdn, San Antonio, TX USA.
   [Lavender, Jason M.; Haigney, Mark C.] Uniformed Serv Univ Hlth Sci, Dept Med, Bethesda, MD USA.
   [Emerick, Jill E.] Uniformed Serv Univ Hlth Sci, Dept Pediat, Bethesda, MD USA.
   [Tanofsky-Kraff, Marian] Uniformed Serv Univ Hlth Sci, Dept Med & Clin Psychol, Bethesda, MD USA.
   [Gutierrez-Colina, Ana M.] Univ Colorado Anschutz, Dept Pediat, Sect Endocrinol, Aurora, CO 80045 USA.
   [Gutierrez-Colina, Ana M.] Childrens Hosp Colorado, Aurora, CO 80045 USA.
C3 Colorado State University System; Colorado State University Fort
   Collins; University of Colorado System; University of Colorado Anschutz
   Medical Campus; Children's Hospital Colorado; Colorado School of Public
   Health; Uniformed Services University of the Health Sciences - USA;
   Uniformed Services University of the Health Sciences - USA; Uniformed
   Services University of the Health Sciences - USA; Uniformed Services
   University of the Health Sciences - USA; University of Colorado System;
   University of Colorado Anschutz Medical Campus; Children's Hospital
   Colorado
RP Gutierrez-Colina, AM (corresponding author), Colorado State Univ, Dept Human Dev & Family Studies, Ft Collins, CO 80523 USA.; Gutierrez-Colina, AM (corresponding author), Univ Colorado Anschutz, Dept Pediat, Sect Endocrinol, Aurora, CO 80045 USA.; Gutierrez-Colina, AM (corresponding author), Childrens Hosp Colorado, Aurora, CO 80045 USA.
EM ana.gutierrez_colina@colostate.edu
RI Sanchez, Natalia/KGL-7474-2024; Heroy, Andrew/IQT-0868-2023
OI Aichele, Stephen/0000-0002-3397-7921; Spinner,
   Holly/0000-0001-7094-0864; Lavender, Jason/0000-0001-9853-2280; Sanchez,
   Natalia/0000-0001-7929-4029; Arnold, Thomas/0009-0003-9665-4518
FU Defense Health Agency [HU00011920029]; Defense Health Agency (DHA)
FX This research was funded by the Defense Health Agency (DHA), grant
   number HU00011920029, and awarded to Marian Tanofsky-Kraff and Mark C.
   Haigney.
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NR 66
TC 1
Z9 1
U1 2
U2 9
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0276-3478
EI 1098-108X
J9 INT J EAT DISORDER
JI Int. J. Eating Disord.
PD MAY
PY 2024
VL 57
IS 5
SI SI
BP 1213
EP 1223
DI 10.1002/eat.24177
EA FEB 2024
PG 11
WC Psychology, Clinical; Nutrition & Dietetics; Psychiatry; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Nutrition & Dietetics; Psychiatry
GA QN7C1
UT WOS:001174160900001
PM 38415929
DA 2025-06-11
ER

PT J
AU Singh, A
   Vellapandian, C
AF Singh, Ankul
   Vellapandian, Chitra
TI High Risk of Metabolic Complications Due to High Consumption of
   Processed Foods
SO CURRENT NUTRITION & FOOD SCIENCE
LA English
DT Review
DE Obesity; junk foods; adolescents; metabolic syndrome; insulin
   resistance; nutritional deficiency
ID HIGH-FAT DIET; CUE-INDUCED MOTIVATION; INSULIN-RESISTANCE;
   ALZHEIMERS-DISEASE; INCREASES ANXIETY; SPATIAL MEMORY; OBESITY;
   MECHANISMS; IMPAIRMENT; LIFE
AB The lack of knowledge among adolescents makes them more sensitive to engaging in unhealthy habits, which might harm their health and nutritional status. A high caloric diet and lack of physical activity generate reactive oxygen species, leading to neurological diseases. The gap in knowledge regarding junk food and its complications poses a significant threat to public health policy. Metabolic syndrome develops from high fat-induced chronic inflammation and leads to cognition disturbances, stroke, and neurological diseases like Alzheimer's. Adolescent age is the most devastating one, in which several lifestyle-associated diseases occur that are associated with chronic diseases, such as Alzheimer's, non-alcoholic steatohepatitis, Type 2 diabetes mellitus, non-alcoholic fatty liver disease, obesity, hypertension, etc. The disordered eating behaviors should be prevented at the earliest to overcome the "fast food genocide" from eating processed foods, leading to obesity and nutritional deficiencies, which further cause neurological complications and destroy the brain cell. As we age, memory begins to decline. Thus, lowering our intake of high-calorie-rich foods and salt could reduce metabolic syndrome-related and age-related issues like blood pressure, T2DM, obesity, etc. Thus, to curb diseases linked with junk foods, awareness about nutritional values among adolescents and higher tax slabs on junk foods should be imposed to reduce the purchase of such products.
C1 [Singh, Ankul; Vellapandian, Chitra] SRM Coll Pharm, SRM IST, Dept Pharmacol, Kancheepuram, Tamil Nadu, India.
C3 SRM Institute of Science & Technology Chennai
RP Vellapandian, C (corresponding author), SRM Coll Pharm, SRM IST, Dept Pharmacol, Kancheepuram, Tamil Nadu, India.
EM chitrav@srmist.edu.in
RI Singh, Ankul/ABH-7217-2022; Vellapandian, Chitra/ABE-9892-2021
OI /0000-0001-7927-0983
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NR 126
TC 1
Z9 1
U1 3
U2 10
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1573-4013
EI 2212-3881
J9 CURR NUTR FOOD SCI
JI Curr. Nutr. Food Sci.
PY 2023
VL 19
IS 3
BP 198
EP 208
DI 10.2174/1573401318666220622162038
PG 11
WC Nutrition & Dietetics
WE Emerging Sources Citation Index (ESCI)
SC Nutrition & Dietetics
GA F1RW9
UT WOS:000980199200002
DA 2025-06-11
ER

PT J
AU Yamagishi, S
   Nakamura, K
   Takeuchi, M
AF Yamagishi, S
   Nakamura, K
   Takeuchi, M
TI Inhibition of postprandial hyperglycemia by acarbose is a promising
   therapeutic strategy for the treatment of patients with the metabolic
   syndrome
SO MEDICAL HYPOTHESES
LA English
DT Article
ID OXIDATIVE STRESS; PROGRESSION; PREVENTION; RISK
AB The metabolic syndrome is strongly associated with insulin resistance and has been recognized as a cluster of risk factors for cardiovascular diseases such as viscera[ obesity, hypertension, diabetes, and atherogenic dyslipidemia. Recently, insulin resistance in the absence of overt diabetes or the metabolic syndrome itself has been associated with endothelial dysfunction, one of the initial steps in the process of atherosclerosis. Postprandial hyperglycemia, one of the characteristic features of insulin resistance, induces oxidative stress generation and elicits vascular inflammation and platelet activation, thus being involved in the pathogenesis of atherosclerosis. A recent multicenter, placebo-controlled randomized trial, STOP-NIDDM trial, revealed that acarbose (Glucobay(R)), an a-glucosidase inhibitor, improved postprandial hyperglycemia and subsequently reduced the risk of development of type 2 diabetes in patients with impaired glucose tolerance (IGT). In this study, acarbose treatment was also found to stow the progression of intima-media thickness of the carotid arteries, a surrogate marker for atherosclerosis, and to reduce the incidence of cardiovascular diseases and newly diagnosed hypertension in subjects with IGT. Acarbose significantly reduced body mass index and waist circumference in these patients over 3 years. Furthermore, a metaanalysis of seven long-term studies has also shown that intervention with acarbose prevents myocardial infarction and cardiovascular diseases in type 2 diabetic patients. In this analysis, glycemic control, triglyceride levels, body weight and systolic blood pressure was also significantly improved during acarbose treatment. These observations suggest that prevention of postprandial hyperglycemia by acarbose may be a promising therapeutic strategy for reducing the increased risk for diabetes, hypertension, dyslipidemia, obesity, and cardiovascular diseases in patients with the metabolic syndrome. Acarbose improves postprandial hyperglycemia by delaying the release of glucose from complex carbohydrates in the absence of an increase in insulin secretion. Therefore, we would like to hypothesize here that this improvement in glucose metabolism could be associated with amelioration in insulin sensitivity, thus explaining the above-mentioned beneficial cardiometabolic actions of acarbose. Large clinical trials will provide us with more definite information whether acarbose treatment can improve insulin sensitivity and resuttantly reduce the risk of diabetes, hypertension and cardiovascular diseases in patients with the metabolic syndrome. (c) 2005 Elsevier Ltd. All rights reserved.
C1 Kurume Univ, Sch Med, Dept Med, Kurume, Fukuoka 8300011, Japan.
   Hokuriku Univ, Dept Biochem, Kanazawa, Ishikawa, Japan.
C3 Kurume University; Hokuriku University
RP Kurume Univ, Sch Med, Dept Med, 67 Asahi Machi, Kurume, Fukuoka 8300011, Japan.
EM shoichi@med.kurume-u.ac.jp
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NR 12
TC 39
Z9 41
U1 0
U2 9
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0306-9877
EI 1532-2777
J9 MED HYPOTHESES
JI Med. Hypotheses
PY 2005
VL 65
IS 1
BP 152
EP 154
DI 10.1016/j.mehy.2004.12.008
PG 3
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 932DW
UT WOS:000229535400026
PM 15893133
DA 2025-06-11
ER

PT J
AU Gavurova, B
   Tarhanicova, M
AF Gavurova, Beata
   Tarhanicova, Miriama
TI Young Adults and Sick Leave Length of Mental Illnesses
SO FRONTIERS IN PUBLIC HEALTH
LA English
DT Article
DE mental diseases; substance use; health literacy; young adults; public
   health
ID MAJOR DEPRESSIVE DISORDER; HEALTH LITERACY; METABOLIC SYNDROME; BIPOLAR
   DISORDER; COMPONENTS; BEHAVIORS
AB ObjectivesThe objective was to explore whether a sick leave length related to mental morbidity differs across different occupational categories. MethodsIn the analysis, registry of sick leaves was analyzed. Provided analysis is focused on the length of sick leaves related to mental diseases caused by substance use or other factors. Dependent variable is the sick leave length, and the independent variables are the categories of disease and occupation. Kruskal-Wallis test, Shapiro-Wilk test, and Brown-Forsythe (B-F) are used. ResultsThere are differences in mental sick leave lengths caused by substance use or other factors. In the case of mental illnesses attributable to drugs, differences in the sick leave duration among different working groups were not found. Considering mental disorders caused by other factors, there are differences in the sick leave duration among different working groups. ConclusionsThere is no evidence of longer sick leave in people diagnosed with mental disorder related to substance use. Differences in occupational categories do not relate to sick leave length.
C1 [Gavurova, Beata] Tomas Bata Univ Zlin, Fac Management & Econ, Zlin, Czech Republic.
   [Tarhanicova, Miriama] Tech Univ Kosice, Fac Min Ecol Proc Control & Geotechnol, Kosice, Slovakia.
C3 Tomas Bata University Zlin; Technical University Kosice
RP Gavurova, B (corresponding author), Tomas Bata Univ Zlin, Fac Management & Econ, Zlin, Czech Republic.
EM gavurova@utb.cz
RI Gavurova, Beata/N-9159-2018
OI Gavurova, Beata/0000-0002-0606-879X
FU Internal Grant Agency of FaME Tomas Bata University in Zlin [RO/2022];
   Slovak Research and Development Agency [APVV-17-0360]
FX This work was supported by Internal Grant Agency of FaME Tomas Bata
   University in Zlin: RO/2022: Use of corporate social responsibility in
   the hospitalisation sector in the Czech Republic and the Slovak Republic
   to increase efficiency and sustainability of the health systems and the
   Slovak Research and Development Agency: Contract No. APVV-17-0360:
   Multidimensional analysis of significant determinants of public
   procurement efficiency with emphasis on the application of Health
   Technology Assessment in the procurement preparation phase.
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NR 44
TC 0
Z9 0
U1 0
U2 16
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 2296-2565
J9 FRONT PUBLIC HEALTH
JI Front. Public Health
PD JUN 13
PY 2022
VL 10
AR 882707
DI 10.3389/fpubh.2022.882707
PG 9
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA 2L2NJ
UT WOS:000816856200001
PM 35769771
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Sivasankari, R
   Usha, B
AF Sivasankari, Ramadurai
   Usha, Balasundaram
TI Reshaping the Gut Microbiota Through Lifestyle Interventions in Women
   with PCOS: A Review
SO INDIAN JOURNAL OF MICROBIOLOGY
LA English
DT Review
DE Circadian rhythm; Gut microbiota; Healthy diet; Lifestyle management;
   PCOS; Probiotics
ID POLYCYSTIC-OVARY-SYNDROME; FECAL MICROBIOTA; INFLAMMATORY MARKERS;
   METABOLIC SYNDROME; GRANULOSA-CELLS; YOGA PROGRAM; DEPRESSION;
   MELATONIN; INSULIN; IMPACT
AB Polycystic ovary syndrome (PCOS) is an endocrine disorder evolving as a global threat to women's health. However, its multifactorial etiology causes difficulty in eliminating it. The interrelation between the gut microbiota and metabolic disorders has been trending recently, giving rise to new opportunities on the etiology and pathogenesis of PCOS. Lifestyle interventions such as healthy diet, physical exercises, and behavioral interventions such as regulation of stress and sleep cycles have been identified to improve the symptoms of PCOS across the endocrinological, metabolic and psychological scales and are recommended as the first line of treatment for PCOS. The impact of the unhealthy lifestyle factors on intestinal dysbiosis that cause PCOS is summarized in this review. This review also provides an insight on the therapeutic approaches that primarily target the gut microbiota and offers novel gut microflora-associated treatment strategies for PCOS. Further, this survey also highlights the need for the implementation of lifestyle management strategies and strongly recommends a healthy and stress-free lifestyle to promote gut health and manage PCOS.
C1 [Sivasankari, Ramadurai; Usha, Balasundaram] SRM Inst Sci & Technol, Dept Genet Engn, Kattankulathur 603203, Tamil Nadu, India.
C3 SRM Institute of Science & Technology Chennai
RP Usha, B (corresponding author), SRM Inst Sci & Technol, Dept Genet Engn, Kattankulathur 603203, Tamil Nadu, India.
EM sundaram.usha@gmail.com
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NR 120
TC 9
Z9 10
U1 3
U2 23
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0046-8991
EI 0973-7715
J9 INDIAN J MICROBIOL
JI Indian J. Microbiol.
PD SEP
PY 2022
VL 62
IS 3
BP 351
EP 363
DI 10.1007/s12088-022-01019-8
EA APR 2022
PG 13
WC Biotechnology & Applied Microbiology; Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Microbiology
GA 3T5OM
UT WOS:000783737400002
PM 35974920
OA Green Published
DA 2025-06-11
ER

PT J
AU Nuankaew, W
   Lee, HK
   Nam, YH
   Shim, JH
   Kim, NW
   Shin, SW
   Kim, MC
   Shin, SY
   Hong, BN
   Dej-adisai, S
   Kwak, JH
   Kang, TH
AF Nuankaew, Wanlapa
   Lee, Hyo Kyu
   Nam, Youn Hee
   Shim, Ji Heon
   Kim, Na Woo
   Shin, Sung Woo
   Kim, Min Cheol
   Shin, Seung Yeon
   Hong, Bin Na
   Dej-adisai, Sukanya
   Kwak, Jong Hwan
   Kang, Tong Ho
TI The Effects of Persimmon (Diospyros kaki L.f.) Oligosaccharides
   on Features of the Metabolic Syndrome in Zebrafish
SO NUTRIENTS
LA English
DT Article
DE Diospyros kaki; persimmon; metabolic syndrome; type 2 diabetes; obesity;
   oligosaccharide
ID PROTEIN-TYROSINE-PHOSPHATASE; INSULIN-RESISTANCE; OXIDATIVE STRESS;
   LIPID-METABOLISM; OBESITY; INFLAMMATION; INHIBITORS; PANCREAS; TARGET;
   PTP1B
AB Metabolic syndrome has become a global health care problem since it is rapidly increasing worldwide. The search for alternative natural supplements may have potential benefits for obesity and diabetes patients. Diospyros kaki fruit extract and its oligosaccharides, including gentiobiose, melibiose, and raffinose, were examined for their anti-insulin resistance and obesity-preventing effect in zebrafish larvae. The results show that D. kaki oligosaccharides improved insulin resistance and high-fat-diet-induced obesity in zebrafish larvae, evidenced by enhanced beta-cell recovery, decreased abdominal size, and reduced the lipid accumulation. The mechanism of the oligosaccharides, molecular docking, and enzyme activities of PTP1B were investigated. Three of the oligosaccharides had a binding interaction with the catalytic active sites of PTP1B, but did not show inhibitory effects in an enzyme assay. The catalytic residues of PTP1B were typically conserved and the cellular penetration of the cell membrane was necessary for the inhibitors. The results of the mechanism of action study indicate that D. kaki fruit extract and its oligosaccharides affected gene expression changes in inflammation- (TNF-alpha, IL-6, and IL-1 beta), lipogenesis- (SREBF1 and FASN), and lipid-lowering (CPT1A)-related genes. Therefore, D. kaki fruit extract and its oligosaccharides may have a great potential for applications in metabolic syndrome drug development and dietary supplements.
C1 [Nuankaew, Wanlapa; Lee, Hyo Kyu; Nam, Youn Hee; Shim, Ji Heon; Kim, Na Woo; Shin, Sung Woo; Kim, Min Cheol; Shin, Seung Yeon; Hong, Bin Na; Kang, Tong Ho] Kyung Hee Univ, Dept Oriental Med Biotechnol, Coll Life Sci, Global Campus, Yongin 17104, South Korea.
   [Dej-adisai, Sukanya] Prince Songkla Univ, Fac Pharmaceut Sci, Dept Pharmacognosy & Pharmaceut Bot, Hat Yai 90112, Thailand.
   [Kwak, Jong Hwan] Sungkyunkwan Univ, Sch Pharm, Suwon 16419, South Korea.
C3 Kyung Hee University; Prince of Songkla University; Sungkyunkwan
   University (SKKU)
RP Kang, TH (corresponding author), Kyung Hee Univ, Dept Oriental Med Biotechnol, Coll Life Sci, Global Campus, Yongin 17104, South Korea.
EM panjae@khu.ac.kr
RI Dej-adisai, Sukanya/AAW-1083-2020; Nuankaew, Wanlapa/AAE-3485-2019
OI Kwak, Jong Hwan/0000-0002-8327-3703; Kang, Tong Ho/0000-0002-4161-6798;
   Nuankaew, Wanlapa/0000-0001-5267-6203; Shin, Sung
   Woo/0000-0003-1038-3749
FU Korea Institute of Planning and Evaluation for Technology in Food,
   Agriculture, Forestry and Fisheries (KR) - Ministry of Agriculture, Food
   and Rural Affairs [317071-03-3-CG000]
FX This research was funded by Korea Institute of Planning and Evaluation
   for Technology in Food, Agriculture, Forestry and Fisheries (KR), funded
   by Ministry of Agriculture, Food and Rural Affairs (317071-03-3-CG000).
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NR 39
TC 6
Z9 7
U1 3
U2 22
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD AUG
PY 2022
VL 14
IS 16
AR 3249
DI 10.3390/nu14163249
PG 15
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 4B6IK
UT WOS:000845878300001
PM 36014755
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Masaki, N
   Takase, B
   Satomura, K
   Akima, T
   Matsushima, Y
   Hosaka, H
   Hamabe, A
   Kurita, A
   Ohsuzu, F
AF Masaki, N
   Takase, B
   Satomura, K
   Akima, T
   Matsushima, Y
   Hosaka, H
   Hamabe, A
   Kurita, A
   Ohsuzu, F
TI Provocation of microvessel spasm by low-dose acetylcholine in patients
   with suspected coronary artery disease - Two case reports
SO ANGIOLOGY
LA English
DT Article
ID ST-SEGMENT ELEVATION; CARDIAC SYNDROME-X; ANGINA-PECTORIS; MICROVASCULAR
   ANGINA; FOLLOW-UP; CONSTRICTION; PERFUSION; STRESS
AB Endothelial dysfunction plays an important role in the pathogenesis of cardiac syndrome X, and intracoronary low-dose acetylcholine infusion is a widely used diagnostic modality for studying the coronary artery endothelial function. The authors herein report 2 cases of cardiac syndrome X with coronary artery endothelial dysfunction and microvessel spasm. The findings of non-invasive testing were positive for ischemia. Coronary angiograms appeared entirely normal in both cases. However, the intracoronary infusion of low-dose (1.5-15 mu g/minute) acetylcholine demonstrated an impairment of the coronary blood flow response and consequently provoked an ST-segment elevation in an electrocardiogram. The coronary angiograms showed no spasm in the epicardial arteries. These patients are thus suggested to have cardiac syndrome X with microvessel spasms associated with coronary artery endothelial dysfunction.
C1 Natl Def Med Coll, Dept Internal Med 1, Tokorozawa, Saitama 3598513, Japan.
   Natl Def Med Coll, Res Ctr, Tokorozawa, Saitama 3598513, Japan.
C3 National Defense Medical College - Japan; National Defense Medical
   College - Japan
RP Natl Def Med Coll, Dept Internal Med 1, 3-2 Namiki, Tokorozawa, Saitama 3598513, Japan.
EM bonpeit@me.ndmc.ac.jp
OI Akima, Takashi/0000-0002-2059-5780
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NR 21
TC 1
Z9 1
U1 0
U2 0
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0003-3197
EI 1940-1574
J9 ANGIOLOGY
JI Angiology
PD MAR-APR
PY 2005
VL 56
IS 2
BP 211
EP 216
DI 10.1177/000331970505600211
PG 6
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 909HT
UT WOS:000227851700011
PM 15793610
DA 2025-06-11
ER

PT J
AU Ferdinand, KC
AF Ferdinand, Keith C.
TI An Overview of Cardiovascular-Kidney-Metabolic Syndrome
SO AMERICAN JOURNAL OF MANAGED CARE
LA English
DT Article
ID HEART-FAILURE; RISK-FACTORS; SCIENTIFIC STATEMENT; SOCIAL DETERMINANTS;
   MORTALITY RISK; DISEASE; PREVALENCE; OUTCOMES; MANAGEMENT; OBESITY
AB Cardio-kidney-metabolic (CKM) syndrome is a term to describe the interconnection between cardiovascular disease, type 2 diabetes, and chronic kidney disease. The National Health and Nutrition Examination Survey from 1999 to 2020 estimated that 25% of participants had at least 1 CKM condition. It is proposed that CKM syndrome originates in excess and/or dysfunctional adipose tissue, which secretes proinflammatory and prooxidative products leading to damaged tissues in arteries, the heart, and the kidney, and reduction in insulin sensitivity. CKM syndrome is classified into 4 stages based on the presence of risk factors and clinical signs. Risk factors associated with progression of CKM syndrome include chronic inflammatory conditions, family history of diabetes or kidney disease, mental health and sleep disorders, increased levels of elevated high-sensitivity C-reactive protein, and sex-specific risk enhancers. There are substantial racial and ethnic differences, although they are likely due to social determinants of health (SDOH). The American Heart Association suggests that CKM syndrome screening should include both biological factors and SDOH. Interventions in patients with stages 0 to 3 CKM syndrome focus on preventing future cardiovascular events by management of excess adiposity, mainly through diet and exercise in the early stages, then through pharmacological treatment of metabolic syndrome components in later stages. There is a general acceptance that treatment of CKM syndrome should involve a holistic approach to prevention, screening, and management to improve outcomes and reduce long-term morbidity and mortality.
FU Boehringer Ingelheim Pharmaceuticals, Inc; Lilly USA, LLC
FX This supplement was supported by Boehringer Ingelheim Pharmaceuticals,
   Inc and Lilly USA, LLC.
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NR 58
TC 4
Z9 4
U1 8
U2 8
PU MANAGED CARE & HEALTHCARE COMMUNICATIONS LLC
PI PLAINSBORO
PA 666 PLAINSBORO RD, STE 300, PLAINSBORO, NJ 08536 USA
SN 1088-0224
J9 AM J MANAG CARE
JI Am. J. Manag. Care
PD DEC
PY 2024
VL 30
IS 10
SU S
BP S181
EP S188
PG 8
WC Health Care Sciences & Services; Health Policy & Services; Medicine,
   General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services; General & Internal Medicine
GA U6C0F
UT WOS:001412637400001
PM 39705194
DA 2025-06-11
ER

PT J
AU Tarzian, M
   Soudan, M
   Alhajji, M
   Ndrio, M
   Fakoya, AO
AF Tarzian, Martin
   Soudan, Majd
   Alhajji, Muhammed
   Ndrio, Mariana
   Fakoya, Adegbenro O.
TI Lurasidone for Treating Schizophrenia and Bipolar Depression: A Review
   of Its Efficacy
SO CUREUS JOURNAL OF MEDICAL SCIENCE
LA English
DT Review
DE clinical global impressions scale for use in bipolar illness; children's
   depression rating scale-revised; montgomery-asberg depression rating
   scale; clinical global impression-severity scale; positive and negative
   syndrome scale; brief psychiatric rating scale; bipolar depression;
   schizophrenia; lurasidone
ID ACUTELY PSYCHOTIC-PATIENTS; DOUBLE-BLIND; I DEPRESSION; POLYSOMNOGRAPHIC
   MEASURES; PLACEBO; SAFETY; VALPROATE; LITHIUM; 6-WEEK
AB Lurasidone is an antipsychotic medication that blocks dopamine D2 and serotonin 5-hydroxy-tryptamine (5-HT)2A receptors and affects other serotoninergic and noradrenergic receptors. It has rapid absorption and linear pharmacokinetics. The rates of metabolic syndrome for patients taking lurasidone are comparable to placebo groups. Lurasidone is a safe and effective treatment for patients with acute schizophrenia and bipolar depression. It has been found to improve the brief psychiatric rating scale and other secondary measures in schizophrenic patients and reduce depressive symptoms in bipolar I depression. The once-daily administration of lurasidone is generally well-tolerated and does not cause clinically significant differences in extrapyramidal symptoms, adverse effects, or weight gain compared to a placebo. However, lurasidone's effectiveness in combination with lithium or valproate has been mixed. Further research is needed to determine optimal dosing, treatment duration, and combination with other mood stabilizers. Long-term safety and effectiveness and its use in different subpopulations should also be evaluated.
C1 [Tarzian, Martin; Ndrio, Mariana] Univ Med & Hlth Sci, Psychiat, Basseterre, St Kitts & Nevi.
   [Soudan, Majd] Nuvance Hlth Med Practice Primary Care Carmel, Psychiatry, Carmel Hamlet, NY USA.
   [Alhajji, Muhammed] Augusta Univ Univ Georgia Med Partnership, Internal Med, Athens, GA USA.
   [Fakoya, Adegbenro O.] Louisiana State Univ, Cellular Biol & Anat, Hlth Sci Ctr, Shreveport, LA 71103 USA.
C3 University System of Georgia; Augusta University; Louisiana State
   University System; Louisiana State University Health Sciences Center at
   Shreveport
RP Fakoya, AO (corresponding author), Louisiana State Univ, Cellular Biol & Anat, Hlth Sci Ctr, Shreveport, LA 71103 USA.
EM gbenrofakoya@gmail.com
RI Fakoya, Adegbenro/V-8886-2017
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NR 24
TC 7
Z9 8
U1 0
U2 2
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
EI 2168-8184
J9 CUREUS J MED SCIENCE
JI Cureus J Med Sci
PD APR 24
PY 2023
VL 15
IS 4
DI 10.7759/cureus.38071
PG 8
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA H4VH5
UT WOS:000995952200023
PM 37228542
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Shen, JY
   Yang, XL
   Meng, ZQ
   Guo, CR
AF Shen, Jinyang
   Yang, Xiaolin
   Meng, Zhaoqing
   Guo, Changrun
TI Protodioscin ameliorates fructose-induced renal injury via inhibition of
   the mitogen activated protein kinase pathway
SO PHYTOMEDICINE
LA English
DT Article
DE Protodioscin; High fructose feeding; Renal injury; Inflammatory; MAPK
   pathway
ID NLRP3 INFLAMMASOME ACTIVATION; NECROSIS-FACTOR-ALPHA;
   DIABETIC-NEPHROPATHY; OXIDATIVE STRESS; KAPPA-B; RATS; PLASMA; KIDNEY;
   ALLOPURINOL; CONSUMPTION
AB Background: High dietary fructose can cause metabolic syndrome and renal injury.
   Purpose: The effects of protodioscin on Metabolic syndrome and renal injury were investigated in mice receiving high-dose fructose.
   Methods: Mice received 30% (w/v) fructose in water and standard chow for 6 weeks to induce metabolic syndrome and were divided into four groups to receive carboxymethylcellulose sodium, allopurinol (5 mg/kg) and protodioscin (5 and 10 mg/kg) continuously for 6 weeks, respectively. The glucose intolerance, serum uric acid (UA), blood urea nitrogen (BUN), creatinine (Cr), total cholesterol (TC), triglyceride (TG), interleukin-1 beta (IL-1 beta), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) were determined.
   Results: Protodioscin significantly improved glucose intolerance and reduced the levels of serum UA, BUN, Cr, TC and TG. Histological examinations showed that protodioscin ameliorated glomerular and tubular pathological changes. Protodioscin significantly reduced renal concentrations of IL-1 beta, IL-6 and TNF-alpha by inhibiting the activation of nuclear factor-kappa B, c-jun N-terminal kinase, p38 mitogen-activated protein kinase and extracellular signal-regulated kinase. In addition, the effect of protodioscin on the mitogen activated protein kinases (MAPK) pathway was examined.
   Conclusion: Taken together, protodioscin is a potential drug candidate for high dietary fructose-induced metabolic syndrome and renal injury. (C) 2016 Elsevier GmbH. All rights reserved.
C1 [Shen, Jinyang; Guo, Changrun] China Pharmaceut Univ, State Key Lab Nat Med, 24 Tongjia Lane, Nanjing 210009, Jiangsu, Peoples R China.
   [Yang, Xiaolin] Nanjing Univ Chinese Med, Jiangsu Key Lab Res & Dev Marine Bioresource Phar, Coll Pharm, Nanjing 210023, Jiangsu, Peoples R China.
   [Meng, Zhaoqing] Jiangsu Kan Pharmaceut Co Ltd, Lianyungang 222001, Peoples R China.
C3 China Pharmaceutical University; Nanjing University of Chinese Medicine
RP Guo, CR (corresponding author), China Pharmaceut Univ, State Key Lab Nat Med, 24 Tongjia Lane, Nanjing 210009, Jiangsu, Peoples R China.
EM crguocpu@126.com
FU College Students Innovation Project for the R&D of Novel Drugs
   [J1030830]
FX This work was supported by a project funded by the College Students
   Innovation Project for the R&D of Novel Drugs (NO. J1030830). The
   assistance of the staff is gratefully acknowledged.
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NR 45
TC 15
Z9 15
U1 0
U2 22
PU ELSEVIER GMBH
PI MUNICH
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SN 0944-7113
EI 1618-095X
J9 PHYTOMEDICINE
JI Phytomedicine
PD NOV 15
PY 2016
VL 23
IS 12
BP 1504
EP 1510
DI 10.1016/j.phymed.2016.08.009
PG 7
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA EB2KZ
UT WOS:000387192300026
PM 27765371
DA 2025-06-11
ER

PT J
AU Jean-Louis, G
   Zizi, F
   Clark, LT
   Brown, CD
   McFarlane, SI
AF Jean-Louis, Girardin
   Zizi, Ferdinand
   Clark, Luther T.
   Brown, Clinton D.
   McFarlane, Samy I.
TI Obstructive Sleep Apnea and Cardiovascular Disease: Role of the
   Metabolic Syndrome and Its Components
SO JOURNAL OF CLINICAL SLEEP MEDICINE
LA English
DT Review
DE Sleep apnea; cardiovascular disease; metabolic syndrome
ID POSITIVE AIRWAY PRESSURE; CORONARY-ARTERY-DISEASE; INDEPENDENT
   RISK-FACTOR; INSULIN-RESISTANCE; BLOOD-PRESSURE; HEART-FAILURE; SYSTEMIC
   HYPERTENSION; GLUCOSE-INTOLERANCE; CARDIAC-ARRHYTHMIAS;
   DIABETES-MELLITUS
AB Although obstructive sleep apnea and cardiovascular disease have common risk factors, epidemiologic studies show that sleep apnea increases risks for cardiovascular disease independently of individuals' demographic characteristics (i.e., age, sex, and race) or risk markers (i.e., smoking, alcohol, obesity, diabetes, dyslipidemia, atrial fibrillation, and hypertension). Individuals with severe sleep apnea are at increased risk for coronary artery disease, congestive heart failure, and stroke. The underlying mechanisms explaining associations between obstructive sleep apnea and cardiovascular disease are not entirely delineated. Several intermediary mechanisms might be involved including sustained sympathetic activation, intrathoracic pressure changes, and oxidative stress. Other abnormalities such as disorders in coagulation factors, endothelial damage, platelet activation, and increased inflammatory mediators might also play a role in the pathogenesis of cardiovascular disease. Linkage between obstructive sleep apnea and cardiovascular disease is corroborated by evidence that treatment of sleep apnea with continuous positive airway pressure reduces systolic blood pressure, improves left ventricular systolic function, and diminishes platelet activation. Several systematic studies are necessary to explicate complex associations between sleep apnea and cardiovascular disease, which may be compounded by the involvement of diseases comprising the metabolic syndrome (i.e., central obesity, hypertension, diabetes, and dyslipidemia). Large-scale, population-based studies testing causal models linking among sleep apnea, cardiovascular morbidity, and metabolic syndrome are needed.
C1 [Jean-Louis, Girardin; Zizi, Ferdinand; Clark, Luther T.; Brown, Clinton D.; McFarlane, Samy I.] Suny Downstate Med Ctr, Brooklyn Ctr Hlth Dispar, Brooklyn, NY 11203 USA.
   [Jean-Louis, Girardin; Zizi, Ferdinand] Suny Downstate Med Ctr, Dept Neurol, Sleep Disorders Ctr, Brooklyn, NY 11203 USA.
   [Jean-Louis, Girardin; Zizi, Ferdinand] Brooklyn Res Fdn Minor Hlth, Kingsbrook Jewish Med Ctr, Brooklyn, NY USA.
   [McFarlane, Samy I.] Suny Downstate Med Ctr, Div Endocrinol Diabet & Hypertens, Brooklyn, NY 11203 USA.
C3 State University of New York (SUNY) System; SUNY Downstate Health
   Sciences University; State University of New York (SUNY) System; SUNY
   Downstate Health Sciences University; State University of New York
   (SUNY) System; SUNY Downstate Health Sciences University
RP Jean-Louis, G (corresponding author), Suny Downstate Med Ctr, Box 1199,450 Clarkson Ave, Brooklyn, NY 11203 USA.
EM gjean-louis@downstate.edu
OI Jean-Louis, Girardin/0000-0001-6777-2724
FU NIH [1R24MD001090, HL085042]
FX This research was supported by funding from the NIH (1R24MD001090 and
   HL085042).
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NR 134
TC 179
Z9 197
U1 0
U2 15
PU AMER ACAD SLEEP MEDICINE
PI DARIEN
PA 2510 N FRONTAGE RD, DARIEN, IL 60561 USA
SN 1550-9389
EI 1550-9397
J9 J CLIN SLEEP MED
JI J. Clin. Sleep Med.
PY 2008
VL 4
IS 3
BP 261
EP 272
PG 12
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA V44VQ
UT WOS:000209776900012
PM 18595441
DA 2025-06-11
ER

PT J
AU Alvisi, S
   Baldassarre, M
   Lambertini, M
   Martelli, V
   Berra, M
   Moscatiello, S
   Marchesini, G
   Venturoli, S
   Meriggiola, MC
AF Alvisi, Stefania
   Baldassarre, Maurizio
   Lambertini, Martina
   Martelli, Valentina
   Berra, Marta
   Moscatiello, Simona
   Marchesini, Giulio
   Venturoli, Stefano
   Meriggiola, Maria Cristina
TI Sexuality and Psychopathological Aspects in Premenopausal Women with
   Metabolic Syndrome
SO JOURNAL OF SEXUAL MEDICINE
LA English
DT Article
DE Metabolic Syndrome; Female Sexual Dysfunction (FSD); Female Sexual
   Function Index (FSFI); Female Sexual Distress Scale (FSDS); Middlesex
   Hospital Questionnaire (MHQ)
ID FUNCTION INDEX FSFI; DISTRESS SCALE FSDS; VAGINAL ENGORGEMENT;
   DYSFUNCTION; PREVALENCE; VALIDATION; INSUFFICIENCY; DEPRESSION; OBESITY;
   HEALTH
AB Introduction. Metabolic syndrome (MetS) is a cluster of cardiovascular risk factors that have been suggested to impact female sexual function.
   Aims. This study aims to assess the prevalence of female sexual dysfunction (FSD) in premenopausal women with MetS compared with healthy controls (HC). Psychopathological aspects and the relationship to FSD were also evaluated in both groups.
   Methods. Two hundred four premenopausal women, of whom 98 had diagnosis of MetS, were asked to complete the Female Sexual Function Index (FSFI), the Female Sexual Distress Scale (FSDS), and the Middlesex Hospital Questionnaire (MHQ). Routine laboratory tests and anthropometric measurements were routinely performed.
   Main Outcome Measures. FSFI and FSDS questionnaires, prevalence of FSD, and MHQ scores.
   Results. In the MetS group compared with the HC group, we found: a lower global FSFI score (P = 0.005), higher prevalence of pathological scores compared with HC group, and lower scores in the desire, arousal, lubrication, and orgasm domains. An inverse correlation between the FSFI score and the number of risk factors for MetS was detected. MetS women reported significantly higher total scores in the somatization and depression domains when compared with the HC group. The logistic regression showed that high triglycerides (odds ratio [OR] 3.097; 95% confidence interval [CI] 1.272-7.542; P = 0.026) and somatization (OR 7.068; CI 95% 2.291-21.812; P = 0.001) are independently associated with FSD in premenopausal women.
   Conclusions. Our results indicate a higher prevalence of sexual dysfunction in MetS women. A number of risk factors for MetS are positively associated with FSD and higher triglycerides seem to be the strongest predictors of sexual dysfunction. Psychopathological dimensions such as somatization are strongly associated with sexual dysfunction.
C1 [Alvisi, Stefania; Lambertini, Martina; Martelli, Valentina; Berra, Marta; Venturoli, Stefano; Meriggiola, Maria Cristina] Univ Bologna, Bologna, Italy.
   [Alvisi, Stefania; Baldassarre, Maurizio; Lambertini, Martina; Martelli, Valentina; Berra, Marta; Moscatiello, Simona; Marchesini, Giulio; Venturoli, Stefano; Meriggiola, Maria Cristina] St Orsola Marcello Malpighi Hosp, Bologna, Italy.
   [Baldassarre, Maurizio; Meriggiola, Maria Cristina] Univ Bologna, Dept Surg & Med Sci, Ctr Appl Biomed Res CRBA, Bologna, Italy.
   [Moscatiello, Simona; Marchesini, Giulio] Univ Bologna, Unit Metab Dis & Clin Dietet, Bologna, Italy.
C3 University of Bologna; IRCCS Azienda Ospedaliero-Universitaria di
   Bologna; University of Bologna; University of Bologna
RP Meriggiola, MC (corresponding author), Alma Mater Studiorum Univ Bologna, S Orsola Malpighi Univ Hosp, Via Massarenti 9, I-40138 Bologna, Italy.
EM cristina.meriggiola@unibo.it
RI Baldassarre, Maurizio/K-6129-2016; Moscatiello, Simona/AAC-4979-2022
OI Baldassarre, Maurizio/0000-0001-7865-394X; Marchesini,
   Giulio/0000-0003-2407-9860; Lambertini, Martina/0000-0003-4282-342X;
   Martelli, Valentina/0000-0003-1578-3645
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NR 35
TC 22
Z9 22
U1 1
U2 1
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1743-6095
EI 1743-6109
J9 J SEX MED
JI J. Sex. Med.
PD AUG
PY 2014
VL 11
IS 8
BP 2020
EP 2028
DI 10.1111/jsm.12585
PG 9
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Urology & Nephrology
GA AN0CX
UT WOS:000340251000014
PM 24848980
DA 2025-06-11
ER

PT J
AU Zhang, SS
   Yong, W
   Cheng, JS
   Ning, HF
   Zhao, RC
   Xu, ZY
   Zhang, FX
   Zheng, WY
   Zhang, DD
AF Zhang, Shuangshuang
   Yong Wang
   Cheng, Jinsong
   Ning Huangfu
   Zhao, Ruochi
   Xu, Zhenyu
   Zhang, Fuxing
   Zheng, Wenyuan
   Zhang, Dandan
TI Hyperuricemia and Cardiovascular Disease
SO CURRENT PHARMACEUTICAL DESIGN
LA English
DT Review
DE Uric acid; hyperuricaemia; cardiovascular diseases; gout; metabolic
   syndrome; chronic kidney disease
ID SERUM URIC-ACID; INCIDENT ATRIAL-FIBRILLATION; OF-RHEUMATOLOGY
   GUIDELINES; URATE-LOWERING THERAPY; BLOOD-PRESSURE; DOUBLE-BLIND;
   INADEQUATE RESPONSE; OXIDATIVE STRESS; GOUT PATIENTS; XANTHINE-OXIDASE
AB Purine metabolism in the circulatory system yields uric acid as its final oxidation product, which is believed to be linked to the development of gout and kidney stones. Hyperuricemia is closely correlated with cardiovascular disease, metabolic syndrome, and chronic kidney disease, as attested by the epidemiological and empirical research. In this review, we summarize the recent knowledge about hyperuricemia, with a special focus on its physiology, epidemiology, and correlation with cardiovascular disease. This review also discusses the possible positive effects of treatment to reduce urate levels in patients with cardiovascular disease and hyperuricemia, which may lead to an improved clinical treatment plan.
C1 [Zhang, Shuangshuang; Yong Wang; Cheng, Jinsong; Ning Huangfu; Zhao, Ruochi; Xu, Zhenyu; Zhang, Fuxing; Zheng, Wenyuan] Ningbo First Hosp, Dept Cardiovasc Med, Ningbo 315000, Zhejiang, Peoples R China.
   [Zhang, Dandan] Ningbo Univ, Med Sch, Affiliated Hosp, Dept Pharm, Ningbo, Zhejiang, Peoples R China.
C3 Ningbo University; Ningbo University
RP Zhang, DD (corresponding author), Ningbo Univ, Med Sch, Affiliated Hosp, Dept Pharm, Ningbo, Zhejiang, Peoples R China.
EM dannizdd@163.com
RI Zhang, Shuangshuang/GVS-0109-2022; Wang, Yong/AEU-9473-2022
FU Zhejiang Provincial Science and Technology Plan Project of Traditional
   Chinese Medicine [2017ZB082]
FX The research was supported by Zhejiang Provincial Science and Technology
   Plan Project of Traditional Chinese Medicine (2017ZB082).
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NR 115
TC 132
Z9 147
U1 4
U2 65
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1381-6128
EI 1873-4286
J9 CURR PHARM DESIGN
JI Curr. Pharm. Design
PY 2019
VL 25
IS 6
BP 700
EP 709
DI 10.2174/1381612825666190408122557
PG 10
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA IC7XK
UT WOS:000471190600010
PM 30961478
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Mravec, B
   Ondicova, K
   Valaskova, Z
   Gidron, Y
   Hulin, I
AF Mravec, Boris
   Ondicova, Katarina
   Valaskova, Zuzana
   Gidron, Yori
   Hulin, Ivan
TI Neurobiological principles in the etiopathogenesis of disease: When
   diseases have a head
SO MEDICAL SCIENCE MONITOR
LA English
DT Review
DE arthritis; atherosclerosis; cancer; diabetes mellitus; inflammation;
   metabolic syndrome; neurobiology; stress
ID INFLAMMATORY-BOWEL-DISEASE; SYMPATHETIC-NERVOUS-SYSTEM; POLYUNSATURATED
   FATTY-ACIDS; RENIN-ANGIOTENSIN SYSTEM; VAGUS NERVE; METABOLIC SYNDROME;
   SENSORY NEURONS; EXPERIMENTAL PANCREATITIS; CARDIOVASCULAR-DISEASE;
   IMMUNE INTERACTIONS
AB There is no doubt that the nervous system is involved in the etiopathogenesis of various pathological states and diseases. Interactions between the nervous, endocrine, and immune systems might represent the anatomical and functional basis for understanding the pathways and mechanisms that enable the brain to modulate the progression of disease. The aim of this article is to encourage us to shift our current opinion of the etiopathogenesis of disease to one of highly complex interactions between peripheral tissues and the brain and in this way introduce new diagnostic and therapeutic approaches.
C1 [Mravec, Boris; Ondicova, Katarina; Valaskova, Zuzana; Hulin, Ivan] Comenius Univ, Fac Med, Inst Pathophysiol, Bratislava 81108, Slovakia.
   [Mravec, Boris] Slovak Acad Sci, Inst Expt Endocrinol, Bratislava, Slovakia.
   [Gidron, Yori] Brunel Univ, Sch Hlth Sci & Social Care, London, England.
C3 Comenius University Bratislava; Slovak Academy of Sciences; Institute of
   Experimental Endocrinology, SAS; Brunel University
RP Mravec, B (corresponding author), Comenius Univ, Fac Med, Inst Pathophysiol, Sasinkova 4, Bratislava 81108, Slovakia.
EM boris.mravec@fmed.uniba.sk
RI Ondicova, Katarina/HJA-3221-2022
OI Ondicova, Katarina/0009-0000-4793-9363; Mravec,
   Boris/0000-0002-3177-6819
FU Slovak Research and Development Agency [APW-0045-06]; VEGA [1/3422/06,
   1/4251/07, 1/4312/07]
FX This study was supported by the Slovak Research and Development Agency
   under contract No. APW-0045-06 and by VEGA grants (1/3422/06, 1/4251/07,
   1/4312/07)
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NR 165
TC 12
Z9 12
U1 0
U2 7
PU INT SCIENTIFIC INFORMATION, INC
PI MELVILLE
PA 150 BROADHOLLOW RD, STE 114, MELVILLE, NY 11747 USA
SN 1643-3750
J9 MED SCI MONITOR
JI Med. Sci. Monitor
PD JAN
PY 2009
VL 15
IS 1
BP RA6
EP RA16
PG 11
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 402YH
UT WOS:000263048500024
PM 19114982
DA 2025-06-11
ER

PT J
AU Honkalampi, K
   Virtanen, M
   Hintsa, T
   Ruusunen, A
   Mäntyselkä, P
   Ali-Sisto, T
   Kärkkäinen, O
   Koivumaa-Honkanen, H
   Valkonen-Korhonen, M
   Panayiotou, G
   Lehto, SM
AF Honkalampi, Kirsi
   Virtanen, Marianna
   Hintsa, Taina
   Ruusunen, Anu
   Mantyselka, Pekka
   Ali-Sisto, Toni
   Karkkainen, Olli
   Koivumaa-Honkanen, Heli
   Valkonen-Korhonen, Minna
   Panayiotou, Georgia
   Lehto, Soili M.
TI Comparison of the level of allostatic load between patients with major
   depression and the general population
SO JOURNAL OF PSYCHOSOMATIC RESEARCH
LA English
DT Article
DE Major depression; Allostatic load; Metabolic; Population
ID ALL-CAUSE; PHYSIOLOGICAL DYSREGULATION; METABOLIC SYNDROME; HEALTH;
   LIFE; SYMPTOMS; RISK; ASSOCIATIONS; DISORDERS; INVENTORY
AB Objective: We compared the level of allostatic load (AL) between patients with major depressive disorder (MDD) and non-depressed controls using two definitions of AL: continuous AL scores (AL index) and clinically significant high AL (>4). We examined whether MDD was associated with AL independent of basic socioeconomic (age, sex, cohabiting status and level of education) and lifestyle factors (smoking and alcohol use).
   Methods: The MDD patient sample consisted of 177 psychiatric outpatients (mean age 33.7, SD 10.7 years), who were recruited from the Department of Psychiatry at Kuopio University Hospital, Finland, in 2016?19. The nondepressed controls (n = 228, mean age 49.8, SD 10.1 years) lived in the municipality of Lapinlahti, Finland. Ten biomarkers were used to construct the two AL variables. These indicators were systolic and diastolic blood pressure, total cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides, glucose, creatinine, waist circumference, body mass index (BMI) and C-reactive protein (CRP).
   Results: The mean AL scores did not significantly differ between MDD patients (2.97) and non-depressed controls (3.12), thus it was not associated with MDD in univariate analysis. In multivariate models a higher AL index was associated with a 1.42 to 1.82 times higher likelihood of belonging to the MDD group. Furthermore, we found that high AL (i.e. AL > 4) was associated with MDD, with the likelihood ranging between 2.27 and 2.96 compared with the non-depressed controls in multivariate models.
   Conclusions: Even young adult patients with MDD appear to display clinically significant, high AL compared with non-depressed controls. Thus, it is important to pay attention to the somatic health of depressed patients in addition to their mental health.
C1 [Honkalampi, Kirsi; Virtanen, Marianna; Hintsa, Taina] Univ Eastern Finland, Sch Educ Sci & Psychol, POB 111, FI-80100 Joensuu, Finland.
   [Ruusunen, Anu; Koivumaa-Honkanen, Heli; Valkonen-Korhonen, Minna] Kuopio Univ Hosp, Dept Psychiat, Kuopio, Finland.
   [Ruusunen, Anu; Mantyselka, Pekka; Ali-Sisto, Toni] Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland.
   [Ruusunen, Anu] Deakin Univ, iMPACT Inst, Food & Mood Ctr, Sch Med, Geelong, Vic, Australia.
   [Mantyselka, Pekka] Kuopio Univ Hosp, Primary Hlth Care Unit, Kuopio, Finland.
   [Karkkainen, Olli] Univ Eastern Finland, Sch Pharm, Kuopio, Finland.
   [Koivumaa-Honkanen, Heli; Valkonen-Korhonen, Minna] Univ Eastern Finland, Inst Clin Med, Kuopio, Finland.
   [Panayiotou, Georgia] Univ Cyprus, Clin Psychol & Psychophysiol Lab, Nicosia, Cyprus.
   [Lehto, Soili M.] Univ Oslo, Inst Clin Med, Oslo, Norway.
   [Lehto, Soili M.] Akershus Univ Hosp, Div Mental Hlth Serv, R&D Dept, Lorenskog, Norway.
   [Lehto, Soili M.] Univ Helsinki, Dept Psychiat, Helsinki, Finland.
C3 University of Eastern Finland; University of Eastern Finland; University
   of Eastern Finland Hospital; Kuopio University Hospital; University of
   Eastern Finland; Deakin University; University of Eastern Finland;
   University of Eastern Finland Hospital; Kuopio University Hospital;
   University of Eastern Finland; University of Eastern Finland; University
   of Cyprus; University of Oslo; University of Oslo; University of
   Helsinki
RP Honkalampi, K (corresponding author), Univ Eastern Finland, Sch Educ Sci & Psychol, POB 111, FI-80100 Joensuu, Finland.
EM kirsi.honkalampi@uef.fi
RI Panayiotou, Georgia/H-4835-2015; Hintsa, Taina/C-6238-2008;
   Koivumaa-Honkanen, Heli/L-1274-2015; Kärkkäinen, Olli/I-3707-2019;
   Ali-Sisto, Toni/JPA-2204-2023
OI Lehto, Soili/0000-0003-4324-6679; Karkkainen, Olli/0000-0003-0825-4956;
   Panayiotou, Georgia/0000-0003-2471-9960; Hintsa,
   Taina/0000-0003-3765-8343
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NR 53
TC 15
Z9 18
U1 1
U2 8
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-3999
EI 1879-1360
J9 J PSYCHOSOM RES
JI J. Psychosomat. Res.
PD APR
PY 2021
VL 143
AR 110389
DI 10.1016/j.jpsychores.2021.110389
EA FEB 2021
PG 7
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA RF8FI
UT WOS:000635073600001
PM 33609985
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Streel, S
   Donneau, AF
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   Albert, A
   Schoenen, J
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AF Streel, Sylvie
   Donneau, Anne-Francoise
   Dardenne, Nadia
   Hoge, Axelle
   Albert, Adelin
   Schoenen, Jean
   Guillaume, Michele
TI Screening for the metabolic syndrome in subjects with migraine
SO CEPHALALGIA
LA English
DT Article
DE Metabolic syndrome; migraine with and without aura
ID CARDIOVASCULAR RISK-FACTORS; EXTENDED FRENCH VERSION; 11-YEAR FOLLOW-UP;
   OXIDATIVE STRESS; INSULIN-RESISTANCE; ID MIGRAINE(TM); HEADACHE; HEALTH;
   STROKE
AB Background: Metabolic syndrome (MetS) and migraine are known to be associated. This study assessed the risk of MetS and its clinical characteristics in migraine with aura (MA) and without aura (MO) based on a large-scale cross-sectional survey.
   Methods: The study material consisted of 751 participants in the Nutrition, Environment and CardioVascular Health (NESCaV) survey. Diagnosis of migraine was based on the ef-ID migraine questionnaire and MetS was defined according to the Revised-Adult Treatment Panel III criteria. Sociodemographic and risk factors were also recorded. Weighted logistic regression was used to assess the risk of MetS.
   Results: After adjusting for stratification (gender, age, district) and other factors (smoking status, sedentary lifestyle, family history of stroke, myocardial infarction and hypertension), MA subjects were at higher risk of MetS (OR 3.45; 95% CI: 1.63-7.29) while MO individuals were not, when compared to non-migraineurs. When considering MetS components, MA was positively associated with low HDL-cholesterol (OR 2.26; 95% CI: 1.08-4.74), hyperglycemia (OR 2.77; 95% CI: 1.30-5.88) and abdominal obesity (OR 2.03; 95% CI: 1.07-3.86).
   Conclusion: Migraineurs with aura are at higher risk of MetS, suggesting that these subjects, already more exposed to stroke, may benefit from a systematic screening for the metabolic syndrome.
C1 [Streel, Sylvie; Donneau, Anne-Francoise; Dardenne, Nadia; Hoge, Axelle; Albert, Adelin; Guillaume, Michele] Univ Liege, Dept Publ Hlth, Ave Hippocrate 13 B23, B-4000 Liege, Belgium.
   [Schoenen, Jean] Univ Liege, CHR Citadelle, Dept Neurol, Headache Res Unit, Liege, Belgium.
C3 University of Liege; University of Liege
RP Streel, S (corresponding author), Univ Liege, Dept Publ Hlth, Ave Hippocrate 13 B23, B-4000 Liege, Belgium.
EM sylvie.streel@ulg.ac.be
RI Streel, Sylvie/ISB-4074-2023
OI Hoge, Axelle/0000-0001-5008-4159
FU INTERREG IV A program, "Greater Region''; European Regional Development
   Fund (ERDF) [NESCAV] [39/GR/3/3/056]; Walloon Region; University of
   Liege in Belgium
FX The authors disclosed receipt of the following financial support for the
   research, authorship and/or publication of this article: the NESCaV
   survey project was supported by the INTERREG IV A program, "Greater
   Region'', 2007-2013. It was co-funded by the European Regional
   Development Fund (ERDF) [NESCAV No 39/GR/3/3/056], the Walloon Region
   and the University of Liege in Belgium. This study was an ancillary
   study of the NESCaV survey project.
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   World Health Organization, 2003, TECHN REP SER
NR 33
TC 16
Z9 17
U1 0
U2 7
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0333-1024
EI 1468-2982
J9 CEPHALALGIA
JI Cephalalgia
PD OCT
PY 2017
VL 37
IS 12
BP 1180
EP 1188
DI 10.1177/0333102416672494
PG 9
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA FK7CK
UT WOS:000413661800008
PM 27703095
OA hybrid
DA 2025-06-11
ER

PT J
AU Valle, AM
   Radic, Z
   Rana, BK
   Whitfield, JB
   O'Connor, DT
   Martin, NG
   Taylor, P
AF Valle, A. M.
   Radic, Z.
   Rana, B. K.
   Whitfield, J. B.
   O'Connor, D. T.
   Martin, N. G.
   Taylor, P.
TI The cholinesterases: Analysis by pharmacogenomics in man
SO CHEMICO-BIOLOGICAL INTERACTIONS
LA English
DT Article; Proceedings Paper
CT 9th International Meeting on Cholinesterases
CY MAY 06-10, 2007
CL Suzhou, PEOPLES R CHINA
DE Cholinesterase; Cardiovascular function; Metabolic syndrome
ID BLOOD-PRESSURE; GENE; BUTYRYLCHOLINESTERASE; HYPERTENSION; TWINS
AB We have undertaken a study on variations in cholinesterase (ChE) genes in relation to cardiovascular (CV) function and the metabolic syndrome. Peripheral and central nervous system control of cardiovascular (CV) function mediated through cholinergic pathways is critical in homeostatic maintenance of blood pressure and responsiveness to stress. For acetylcholinesterase (AChE; EC 3.1.1.7) our focus is to identify single nucleotide polymorphisms (SNPs) in the gene that are linked to cardiovascular function. For butyrylcholinesterase (BChE; EC 3.1.1.8) we examined whether BChE activity correlated with parameters of the metabolic syndrome and cardiovascular function. ChE can be found in whole blood enabling a characterization of biochemical phenotype in addition to correlating genotype with phenotypic physiologic responses. Analysis of enzymatic activity was determined spectrophotometrically in blood samples from twin and other subject registries. Correlation analysis revealed significant relationships between enzyme activity and certain CV endpoints. Linkage analysis with data from a dizygotic (DZ) twin set showed a suggestive linkage at the BChE locus, and statistical analysis revealed a high correlation between BChE activity and variables associated with cardiovascular risk and the metabolic syndrome. Pattern of within-pair twin correlations by zygosity and the ACE model-fitting findings suggest the major source of this variation (65%) is attributable to an additive genetic component. To date 19 SNPs have been identified by the re-sequencing of AChE including four nonsynonymous coding SNPs (cSNPs). (C) 2008 Elsevier Ireland Ltd. All rights reserved.
C1 [Valle, A. M.; Radic, Z.; O'Connor, D. T.; Taylor, P.] Univ Calif San Diego, Dept Pharmacol, Skaggs Sch Pharm & Pharmaceut Sci, La Jolla, CA 92093 USA.
   [Rana, B. K.; O'Connor, D. T.] Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA.
   [Rana, B. K.] Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA.
   [Whitfield, J. B.; Martin, N. G.] Queensland Inst Med Res, Brisbane, Qld 4006, Australia.
C3 University of California System; University of California San Diego;
   University of California System; University of California San Diego;
   University of California System; University of California San Diego;
   QIMR Berghofer Medical Research Institute
RP Valle, AM (corresponding author), Univ Calif San Diego, Dept Pharmacol, Skaggs Sch Pharm & Pharmaceut Sci, 9500 Gilman Dr 0650, La Jolla, CA 92093 USA.
EM amvalle@ucsd.edu
RI Martin, Nicholas/R-9235-2019
OI Whitfield, John/0000-0002-1103-0876; Martin,
   Nicholas/0000-0003-4069-8020
FU NIGMS NIH HHS [R37 GM018360, T32 GM007752] Funding Source: Medline
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NR 12
TC 8
Z9 8
U1 0
U2 2
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0009-2797
J9 CHEM-BIOL INTERACT
JI Chem.-Biol. Interact.
PD SEP 25
PY 2008
VL 175
IS 1-3
SI SI
BP 343
EP 345
DI 10.1016/j.cbi.2008.04.042
PG 3
WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology
GA 361EO
UT WOS:000260110500065
PM 18541229
OA Green Accepted
DA 2025-06-11
ER

PT J
AU McGlone, ER
   Bloom, SR
AF McGlone, Emma Rose
   Bloom, Stephen R.
TI Bile acids and the metabolic syndrome
SO ANNALS OF CLINICAL BIOCHEMISTRY
LA English
DT Review
DE Bile acids; metabolic syndrome; type 2 diabetes mellitus; non-alcoholic
   fatty liver disease; farnesoid X receptor; Takeda G-protein coupled
   receptor 5
ID FARNESOID-X-RECEPTOR; ENDOPLASMIC-RETICULUM STRESS; 7 ALPHA-HYDROXYLASE;
   INTESTINAL MICROBIOTA; NONALCOHOLIC STEATOHEPATITIS; TRANSCRIPTIONAL
   REGULATION; INSULIN SENSITIVITY; DIURNAL-VARIATION; GUT MICROBIOTA;
   MOUSE MODEL
AB Bile acids have important roles in the regulation of lipid, glucose and energy metabolism. Metabolic diseases linked to obesity, including type 2 diabetes mellitus and non-alcoholic fatty liver disease, are associated with dysregulation of bile acid homeostasis. Here, the basic chemistry and regulation of bile acids as well as their metabolic effects will be reviewed. Changes in circulating bile acids associated with obesity and related diseases will be reviewed. Finally, pharmaceutical manipulation of bile acid homeostasis as therapy for metabolic diseases will be outlined.
C1 [McGlone, Emma Rose; Bloom, Stephen R.] Imperial Coll London, Div Diabet Endocrinol & Metab, London, England.
C3 Imperial College London
RP McGlone, ER (corresponding author), Imperial Coll London, Hammersmith Hosp, Div Diabet Endocrinol & Metab, 6th Floor,Commonwealth Bldg,Du Cane Rd, London W12 0NN, England.
EM e.mcglone@imperial.ac.uk
RI McGlone, Emma/AAT-3599-2020
OI McGlone, Emma Rose/0000-0002-0968-6972
FU MRC; BBSRC; NIHR; Integrative Mammalian Biology (IMB) Capacity Building
   Award; EuroCHIP grant [FP7-HEALTH-2009-241592]; NIHR Biomedical Research
   Centre Funding Scheme; Medical Research Council; MRC [MR/P01870X/1]
   Funding Source: UKRI
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: The
   Section of Endocrinology and Investigative Medicine is funded by grants
   from the MRC, BBSRC, NIHR, an Integrative Mammalian Biology (IMB)
   Capacity Building Award, an FP7-HEALTH-2009-241592 EuroCHIP grant and is
   supported by the NIHR Biomedical Research Centre Funding Scheme. The
   views expressed are those of the authors and not necessarily those of
   aforementioned funders, the NHS, the NIHR or the Department of Health.
   ER McGlone is also funded by the Medical Research Council with a
   clinical research training fellowship.
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NR 150
TC 115
Z9 129
U1 5
U2 57
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0004-5632
EI 1758-1001
J9 ANN CLIN BIOCHEM
JI Ann. Clin. Biochem.
PD MAY
PY 2019
VL 56
IS 3
BP 326
EP 337
DI 10.1177/0004563218817798
PG 12
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA HY5WJ
UT WOS:000468199000003
PM 30453753
DA 2025-06-11
ER

PT J
AU Cabandugama, PK
   Gardner, MJ
   Sowers, JR
AF Cabandugama, Peminda K.
   Gardner, Michael J.
   Sowers, James R.
TI The Renin Angiotensin Aldosterone System in Obesity and Hypertension
   Roles in the Cardiorenal Metabolic Syndrome
SO MEDICAL CLINICS OF NORTH AMERICA
LA English
DT Article
DE Obesity; Insulin resistance; Angiotensin II; Adipocyte; Hypertension
ID ADIPOSE-TISSUE; SYMPATHETIC ACTIVATION; INSULIN-RESISTANCE;
   DIABETES-MELLITUS; LEPTIN; INHIBITION; DIET; DEFICIENCY; SOCIETY
AB In the United States, more than 50 million people have blood pressure at or above 120/80 mm Hg. All components of cardiorenal metabolic syndrome (CRS) are linked to metabolic abnormalities and obesity. A major driver for CRS is obesity. Current estimates show that many of those with hypertension and CRS show some degree of systemic and cardiovascular insulin resistance. Several pathophysiologic factors participate in the link between hypertension and CRS. This article updates recent literature with a focus on the function of insulin resistance, obesity, and renin angiotensin aldosterone system-mediated oxidative stress on endothelial dysfunction and the pathogenesis of hypertension.
C1 [Cabandugama, Peminda K.; Gardner, Michael J.; Sowers, James R.] Univ Missouri, Dept Med, Diabet & Cardiovasc Ctr, Div Endocrinol, D109 Diabet Ctr UHC,One Hosp Dr, Columbia, MO 65212 USA.
   [Sowers, James R.] Univ Missouri, Dept Physiol & Pharmacol, One Hosp Dr, Columbia, MO 65212 USA.
   [Sowers, James R.] Harry S Truman VA Hosp, 800 Hosp Dr, Columbia, MO 65201 USA.
C3 University of Missouri System; University of Missouri Columbia;
   University of Missouri System; University of Missouri Columbia; US
   Department of Veterans Affairs; Veterans Health Administration (VHA);
   Harry S. Truman Memorial Veterans' Hospital
RP Sowers, JR (corresponding author), D109 Diabet Ctr UHC,One Hosp Dr, Columbia, MO 65212 USA.
EM sowersj@health.missouri.edu
FU National Institutes of Health [R01-HL73101, R01-HL107910]; Department of
   Veterans Affairs Biomedical Laboratory Research and Development Merit
   [0018]
FX The research of the authors is supported by funding from the National
   Institutes of Health (R01-HL73101 and R01-HL107910 to J.R. Sowers) and
   the Department of Veterans Affairs Biomedical Laboratory Research and
   Development Merit (0018 to J.R. Sowers).
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NR 43
TC 123
Z9 138
U1 0
U2 13
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0025-7125
EI 1557-9859
J9 MED CLIN N AM
JI Med. Clin. N. Am.
PD JAN
PY 2017
VL 101
IS 1
BP 129
EP +
DI 10.1016/j.mcna.2016.08.009
PG 11
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA EG3UQ
UT WOS:000390970600013
PM 27884224
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Grassi, D
   Desideri, G
   Ferri, C
AF Grassi, Davide
   Desideri, Giovambattista
   Ferri, Claudio
TI New Insight into Urate-Related Mechanism of Cardiovascular Damage
SO CURRENT PHARMACEUTICAL DESIGN
LA English
DT Article
DE Uric acid; hyperuricemia; endothelial dysfunction; oxidative stress;
   cardiovascular risk
AB Several experimental and clinical studies reported that hyperuricemia may trigger hypertension, metabolic syndrome, vascular damage and renal disease. Furthermore, a substantial proportion of epidemiological studies are compatible with the hypothesis that hyperuricemia may be an indipendent risk factor for cardiovascular disease as well as for an increased cardiovascular mortality. Xanthine oxidase is a critical source of reactive oxygen species contributing to vascular inflammation and endothelial dysfunction. Although a causal relationship between these conditions has not been clearly clarified, the capacity of uric acid to negatively affect vascular function by pro-oxidant effects and by decreasing nitric oxide bioavailability and consequently induce endothelial dysfunction may explain the association among hyperuricemia, hypertension, metabolic syndrome, and cardiovascular disease, also by a common mechanicistic point of view.
C1 [Grassi, Davide; Desideri, Giovambattista; Ferri, Claudio] Univ Aquila, Dept Life Hlth & Environm Sci, I-67100 Laquila, Italy.
C3 University of L'Aquila
RP Grassi, D (corresponding author), Univ Aquila, Dept Life Hlth & Environm Sci, Viale S Salvatore,6 Med, I-67100 Laquila, Italy.
EM davide.grassi@cc.univaq.it
RI Ferri, Claudio/AAB-5070-2022; Desideri, Giovambattista/AAB-5079-2022;
   Grassi, Davide/O-6519-2015
OI Grassi, Davide/0000-0003-1005-4689; Ferri, Claudio/0000-0002-3594-2503;
   DESIDERI, Giovambattista/0000-0002-0145-1271
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NR 58
TC 15
Z9 15
U1 0
U2 1
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1381-6128
EI 1873-4286
J9 CURR PHARM DESIGN
JI Curr. Pharm. Design
PY 2014
VL 20
IS 39
BP 6089
EP 6095
DI 10.2174/1381612820666140417095730
PG 7
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA V41UG
UT WOS:000209570500003
PM 24745926
DA 2025-06-11
ER

PT J
AU Zheng, XJ
   Yu, HB
   Qiu, XCH
   Chair, SY
   Wong, EML
   Wang, Q
AF Zheng, Xujuan
   Yu, Hongbo
   Qiu, Xichenhui
   Chair, Sek Ying
   Wong, Eliza Mi-Ling
   Wang, Qun
TI The effects of a nurse-led lifestyle intervention program on
   cardiovascular risk, self-efficacy and health promoting behaviours among
   patients with metabolic syndrome: Randomized controlled trial
SO INTERNATIONAL JOURNAL OF NURSING STUDIES
LA English
DT Article
DE Cardiovascular risk; Health promoting behaviours; Lifestyle
   intervention; Metabolic syndrome; Self-efficacy
ID COMMUNITY-BASED-INTERVENTION; PHYSICAL-ACTIVITY; DISEASE RISK;
   OLDER-ADULTS; FOLLOW-UP; PROFILE; REDUCE; PREVENTION; OUTCOMES; IMPACT
AB Background: Metabolic syndrome is a cluster of cardio-metabolic risk factors and a major burden for public health due to its increasing prevalence and adverse effects on cardiovascular health. Lifestyle modification is the first-line intervention for metabolic syndrome management. However, adopting healthy behaviours is challenging among patients with metabolic syndrome.
   Objective: To examine the effects of a nurse-led lifestyle intervention program on cardiovascular risks, self-efficacy and the implementation of health promoting behaviours.
   Design: A two-armed randomized controlled trial.
   Settings and Participants: A total of 173 patients that satisfied the metabolic syndrome definition of International Diabetes Federation was recruited from a hospital in North China.
   Methods: The participants were randomly assigned to either attend the lifestyle interventions (n = 86) or receive usual care from the study hospital (n = 87). The lifestyle intervention followed the framework of Health Promotion Model and consisted of one face-to-face education session (30-40 min), one educational booklet and six telephone follow-ups (bi-weekly, 20-30 min per call) in three months. The Framingham 10-year risk score was calculated to measure the participants' cardiovascular risks at baseline and 3-month. The Self-rated Abilities for Health Practices and Health Promoting Lifestyle Profile II was employed to measure the self-efficacy and health promoting behaviours at baseline, 1-month, and 3-month. The generalized estimating equation model was employed to examine the effects of the lifestyle intervention program.
   Results: No difference was detected in the baseline characteristics between the two groups. Decreased cardiovascular risk was found in the lifestyle intervention group, but no significant group-by-time effect was detected. The self-efficacy for nutrition, stress dimension and sum score of health promoting behaviours revealed significant improvements at 1-month (all p < 0.05). Significant improvements were also detected in all subscales, total scale of self-efficacy, all dimensions and the sum score of health promoting behaviours at 3-month (all p < 0.05).
   Conclusions: The nurse-led Health Promotion Model guided lifestyle intervention program effectively improved the self-efficacy and implementation of health promoting behaviours in patients with metabolic syndrome. We recommend that nurses apply lifestyle interventions in routine care for patients with metabolic syndrome.
   Tweetable abstract: The RCT revealed that nurse-led lifestyle intervention was effective to improve self-efficacy and healthy behaviours among 173 MetS patients. (C) 2020 The Author(s). Published by Elsevier Ltd.
C1 [Zheng, Xujuan; Qiu, Xichenhui; Wang, Qun] Shenzhen Univ, Sch Nursing, 1066 Xueyuan Rd, Shenzhen 518055, Peoples R China.
   [Yu, Hongbo] Pingdu Peoples Hosp, Dept Endocrinol, Qingdao, Peoples R China.
   [Chair, Sek Ying] Chinese Univ Hong Kong, Nethersole Sch Nursing, Shatin, Hong Kong, Peoples R China.
   [Wong, Eliza Mi-Ling] Hong Kong Polytech Univ, Sch Nursing, Hung Hom, Hong Kong, Peoples R China.
C3 Shenzhen University; Chinese University of Hong Kong; Hong Kong
   Polytechnic University
RP Wang, Q (corresponding author), Shenzhen Univ, Sch Nursing, 1066 Xueyuan Rd, Shenzhen 518055, Peoples R China.
EM zhengxujuan@szu.edu.cn; yuhongbo.doc@163.com; qiuxichenhui@163.com;
   sychair@cuhk.edu.hk; eliza.wong@polyu.edu.hk; qunwang@szu.edu.cn
RI Wong, Eliza/AAH-6193-2020; WANG, Qun/AAP-9908-2021; Yu,
   Hongbo/M-8181-2019; Chair, Sek/IVV-5916-2023
OI Wang, Qun/0000-0001-7594-8312
FU Health Commission of Guangdong Province [A2019067]; Shenzhen University
   [2019126]
FX This study was supported by grants from the Health Commission of
   Guangdong Province (Fund no. A2019067) and Shenzhen University (Fund no.
   2019126). The funding source had no influence on the study design,
   procedure, data analysis, or interpretations of the findings. We
   sincerely thank all the participants of the study.
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NR 52
TC 40
Z9 42
U1 10
U2 97
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0020-7489
EI 1873-491X
J9 INT J NURS STUD
JI Int. J. Nurs. Stud.
PD SEP
PY 2020
VL 109
AR 103638
DI 10.1016/j.ijnurstu.2020.103638
PG 9
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA OC2DS
UT WOS:000578971400027
PM 32553996
OA hybrid
DA 2025-06-11
ER

PT J
AU MacKay-Lyons, M
   Gubitz, G
   Giacomantonio, N
   Wightman, H
   Marsters, D
   Thompson, K
   Blanchard, C
   Eskes, G
   Thornton, M
AF MacKay-Lyons, Marilyn
   Gubitz, Gordon
   Giacomantonio, Nicholas
   Wightman, Howard
   Marsters, David
   Thompson, Kara
   Blanchard, Chris
   Eskes, Gail
   Thornton, Marianne
TI Program of rehabilitative exercise and education to avert vascular
   events after non-disabling stroke or transient ischemic attack (PREVENT
   Trial): a multi-centred, randomised controlled trial
SO BMC NEUROLOGY
LA English
DT Article
ID HEALTH-CARE PROFESSIONALS; ASSOCIATION SCIENTIFIC STATEMENT;
   CORONARY-HEART-DISEASE; PHYSICAL-ACTIVITY; CARDIAC REHABILITATION;
   METABOLIC SYNDROME; CLINICAL CARDIOLOGY; RISK-FACTORS; SECONDARY
   PREVENTION; CONSENSUS STATEMENT
AB Background: Despite lack of outward signs, most individuals after non-disabling stroke (NDS) and transient ischemic attack (TIA) have significant cardiovascular and cerebrovascular disease and are at high risk of a major stroke, hospitalization for other vascular events, or death. Most have multiple modifiable risk factors (e. g., hypertension, physical inactivity, hyperlipidaemia, diabetes, tobacco consumption, psychological stress). In addition, accelerated rates of depression, cognitive decline, and poor quality of sleep have been reported following TIA, which correlate with poor functional outcomes and reduced quality of life. Thus, NSD and TIA are important warning signs that should not be overlooked. The challenge is not unlike that facing other 'silent' conditions - to identify a model of care that is effective in changing people's current behaviors in order to avert further morbidity.
   Methods/Design: A single blind, randomized controlled trial will be conducted at two sites to compare the effectiveness of a program of rehabilitative exercise and education versus usual care in modifying vascular risk factors in adults after NDS/TIA. 250 adults within 90 days of being diagnosed with NDS/TIA will be randomly allocated to a 12-week program of exercise and education (PREVENT) or to an outpatient clinic assessment and discussion of secondary prevention recommendations with return clinic visits as indicated (USUAL CARE). Primary outcome measures will include blood pressure, waist circumference, 12-hour fasting lipid profile, and 12-hour fasting glucose/hemoglobin A1c. Secondary measures will include exercise capacity, walking endurance, physical activity, cognitive function, depression, goal attainment and health-related quality of life. Outcome assessment will be conducted at baseline, post-intervention, and 6- and 12-month follow-ups. Direct health care costs incurred over one year by PREVENT versus USUAL CARE participants will also be compared. Ethical approval for the trial has been obtained from the relevant Human Research Ethics Boards.
   Discussion: Whether timely delivery of an adapted cardiac rehabilitation model is effective in attaining and maintaining vascular risk reduction targets in adults after NDS/TIA is not yet known. We anticipate that the findings of this trial will make a meaningful contribution to the knowledge base regarding secondary stroke prevention. Trial registration: This trial is registered with the Clinical Trials.gov Registry (NCT00885456).
C1 [MacKay-Lyons, Marilyn; Thornton, Marianne] Dalhousie Univ, Sch Physiotherapy, Halifax, NS, Canada.
   [Gubitz, Gordon] QEII Hlth Sci Ctr, Dept Neurol, Halifax, NS, Canada.
   [Giacomantonio, Nicholas] QEII Hlth Sci Ctr, Dept Cardiol, Halifax, NS, Canada.
   [Wightman, Howard; Marsters, David] Valley Reg Hosp, Dept Med, Kentville, NS, Canada.
   [Thompson, Kara; Blanchard, Chris] QEII Hlth Sci Ctr, Dept Med, Halifax, NS, Canada.
   [Eskes, Gail] QEII Hlth Sci Ctr, Dept Psychiat, Halifax, NS, Canada.
C3 Dalhousie University; Queen Elizabeth II Health Sciences Centre; Queen
   Elizabeth II Health Sciences Centre; Queen Elizabeth II Health Sciences
   Centre; Queen Elizabeth II Health Sciences Centre
RP MacKay-Lyons, M (corresponding author), Dalhousie Univ, Sch Physiotherapy, Halifax, NS, Canada.
EM m.mackay-lyons@dal.ca
RI Blanchard, Christopher/P-5124-2016
OI Eskes, Gail/0000-0001-5867-9616; MacKay-Lyons,
   Marilyn/0000-0002-9917-3117
FU Heart and Stroke Foundation of Canada; Canadian Stroke Network; Canadian
   Institutes of Health Research
FX The PREVENT Trial is jointly funded by a grant from the Heart and Stroke
   Foundation of Canada, the Canadian Stroke Network, and the Canadian
   Institutes of Health Research.
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NR 82
TC 33
Z9 38
U1 1
U2 36
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2377
J9 BMC NEUROL
JI BMC Neurol.
PD DEC 8
PY 2010
VL 10
AR 122
DI 10.1186/1471-2377-10-122
PG 9
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 697MZ
UT WOS:000285519000001
PM 21143864
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Vukovic, O
   Tosevski, DL
   Jasovic-Gasic, M
   Damjanovic, A
   Zebic, M
   Britvic, D
   Stepanovic, J
   Djordjevic-Dikic, A
   Beleslin, B
   Ostojic, M
AF Vukovic, Olivera
   Tosevski, Dusica Lecic
   Jasovic-Gasic, Miroslava
   Damjanovic, Aleksandar
   Zebic, Mirjana
   Britvic, Dubravka
   Stepanovic, Jelena
   Djordjevic-Dikic, Ana
   Beleslin, Branko
   Ostojic, Miodrag
TI TYPE D PERSONALITY IN PATIENTS WITH CORONARY ARTERY DISEASE
SO PSYCHIATRIA DANUBINA
LA English
DT Article
DE Type D personality; coronary artery disease; stress; depression
ID MYOCARDIAL-INFARCTION; HEART-FAILURE; CARDIOVASCULAR-DISEASE; NEGATIVE
   EMOTIONS; SOCIAL INHIBITION; SOMATIC HEALTH; RISK-FACTORS; DEPRESSION;
   PREVALENCE; PROGNOSIS
AB Background: During the past decade studies have shown that Type D personality is associated with increased risk of cardiac events, mortality and poor quality of life. Some authors suggested that depression and Type D personality have substantial phenomenological overlap.
   Subjects and methods: The sample consisted of non-consecutive case series of seventy nine patients with clinically stable and angiographically confirmed coronary artery disease (CAD), who had been admitted to the Clinic of Cardiology, University Clinical Centre, from May 2006 to September 2008. The patients were assessed by the Type-D scale (DS14), The Beck Depression Inventory (BDI), and provided demographic information. Risk factors for CAD were obtained from cardiologists.
   Results: The findings of our study have shown that 34.2% patients with CAD could be classified as Type D personality. The univariate analysis has shown that the prevalence of Type D personality was significantly higher in individuals with unstable angina pectoris and myocardial infarction (MI) diagnoses (p=0.02). Furthermore, some components of metabolic syndrome were more prevalent in patients with Type D personality: hypercholesterolemia (p=0.00), hypertriglyceridemia (p=0.00) and hypertension (p=0.01). Additionally, the distribution of depression in patients with a Type D personality and a non-Type D personality were statistically significantly different (p=0.00).
   Conclusion: To our knowledge, this study is the first one to describe the prevalence and clinical characteristics of the Type D personality in patients with CAD in this region of Europe. We have found that the prevalence of Type D personality in patients with CAD is in concordance with the other studies. We also have found that Type D personality and depression are two distinctly different categories of psychological distress.
C1 [Vukovic, Olivera; Tosevski, Dusica Lecic; Jasovic-Gasic, Miroslava; Damjanovic, Aleksandar; Stepanovic, Jelena; Djordjevic-Dikic, Ana; Beleslin, Branko; Ostojic, Miodrag] Univ Belgrade, Sch Med, Belgrade, Serbia.
   [Vukovic, Olivera; Tosevski, Dusica Lecic] Inst Mental Hlth, Belgrade 11000, Serbia.
   [Damjanovic, Aleksandar; Zebic, Mirjana; Britvic, Dubravka] Clin Ctr Serbia, Psychiat Clin, Belgrade, Serbia.
   [Stepanovic, Jelena; Djordjevic-Dikic, Ana; Beleslin, Branko] Clin Ctr Serbia, Clin Cardiol, Belgrade, Serbia.
C3 University of Belgrade; Clinical Centre of Serbia; Clinical Centre of
   Serbia
RP Vukovic, O (corresponding author), Inst Mental Hlth, 37 Palmoticeva St, Belgrade 11000, Serbia.
EM olivukovic@gmail.com
RI Vukovic, Olivera/AAP-2960-2020; Britvić, Dolores/D-5819-2017
OI Vukovic, Olivera/0000-0001-6898-0007; Zebic, Mirjana/0000-0002-8696-3056
CR Beck A.T., 1993, MANUAL REVISED BECK
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NR 30
TC 22
Z9 26
U1 0
U2 19
PU MEDICINSKA NAKLADA
PI ZAGREB
PA VLASKA 69, HR-10000 ZAGREB, CROATIA
SN 0353-5053
J9 PSYCHIAT DANUB
JI Psychiatr. Danub.
PY 2014
VL 26
IS 1
BP 46
EP 51
PG 6
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA AK7UE
UT WOS:000338632400007
PM 24608156
DA 2025-06-11
ER

PT J
AU Joven, J
   March, I
   Espinel, E
   Fernández-Arroyo, S
   Rodríguez-Gallego, E
   Aragonès, G
   Beltrán-Debón, R
   Alonso-Villaverde, C
   Rios, L
   Martin-Paredero, V
   Menendez, JA
   Micol, V
   Segura-Carretero, A
   Camps, J
AF Joven, Jorge
   March, Isabel
   Espinel, Eugenia
   Fernandez-Arroyo, Salvador
   Rodriguez-Gallego, Esther
   Aragones, Gerard
   Beltran-Debon, Raul
   Alonso-Villaverde, Carlos
   Rios, Lidia
   Martin-Paredero, Vicente
   Menendez, Javier A.
   Micol, Vicente
   Segura-Carretero, Antonio
   Camps, Jordi
TI Hibiscus sabdariffa extract lowers blood pressure and improves
   endothelial function
SO MOLECULAR NUTRITION & FOOD RESEARCH
LA English
DT Article
DE Diuresis; Hypertension; Inflammation; Oxidative stress; Phytochemicals
ID PLANT-DERIVED POLYPHENOLS; METABOLIC SYNDROME; ANTIOXIDANT; DIET;
   EXPRESSION
AB Polyphenols from Hibiscus sabdariffa calices were administered to patients with metabolic syndrome (125 mg/kg/day for 4 wk, n = 31) and spontaneously hypertensive rats (125 or 60 mg/kg in a single dose or daily for 1 wk, n = 8 for each experimental group). The H. sabdariffa extract improved metabolism, displayed potent anti-inflammatory and antioxidant activities, and significantly reduced blood pressure in both humans and rats. Diuresis and inhibition of the angiotensin I-converting enzyme were found to be less important mechanisms than those related to the antioxidant, anti-inflammatory, and endothelium-dependent effects to explain the beneficial actions. Notably, polyphenols induced a favorable endothelial response that should be considered in the management of metabolic cardiovascular risks.
C1 [Joven, Jorge; Fernandez-Arroyo, Salvador; Rodriguez-Gallego, Esther; Aragones, Gerard; Beltran-Debon, Raul; Alonso-Villaverde, Carlos; Martin-Paredero, Vicente; Camps, Jordi] Univ Rovira & Virgili, Inst Invest Sanitaria Pere Virgili, Hosp Univ St Joan, Unitat Recerca Biomed, Reus, Spain.
   [March, Isabel; Rios, Lidia] Hosp lleuger Cambrils, Tarragona, Spain.
   [Espinel, Eugenia] Hosp Univ Vall dHebron, Dept Nephrol, Barcelona, Spain.
   [Menendez, Javier A.] Catalan Inst Oncol, Girona, Spain.
   [Menendez, Javier A.] Girona Biomed Res Inst, Girona, Spain.
   [Micol, Vicente] Univ Miguel Hernandez, Inst Biol Mol & Celular, Alicante, Spain.
   [Segura-Carretero, Antonio] Univ Granada, Fac Sci, Dept Analyt Chem, Granada, Spain.
C3 Universitat Rovira i Virgili; Institut d'Investigacio Sanitaria Pere
   Virgili (IISPV); Hospital Universitari Vall d'Hebron; Institut Catala
   d'Oncologia; Universitat de Girona; Girona University Hospital Dr. Josep
   Trueta; Institut d'Investigacio Biomedica de Girona (IDIBGI);
   Universidad Miguel Hernandez de Elche; University of Granada
RP Joven, J (corresponding author), Univ Rovira & Virgili, Inst Invest Sanitaria Pere Virgili, Hosp Univ St Joan, Unitat Recerca Biomed, Carrer St Llorenc 21, Reus, Spain.
EM jorge.joven@urv.cat
RI Aragonès, Gerard/AAJ-9150-2021; Camps, Jordi/AAG-3080-2020; Micol,
   Vicente/K-6841-2014; Aragones, Gerard/F-9673-2016; Beltran-Debon,
   Raul/A-9287-2014; Joven, Jorge/B-3360-2016; Fernandez-Arroyo,
   Salvador/M-6955-2015; MENENDEZ MENENDEZ, JAVIER ABEL/C-6148-2016; segura
   Carretero, Antonio/B-6867-2014; Rodriguez-Gallego, Esther/B-6581-2016
OI Aragones, Gerard/0000-0001-8657-5726; Beltran-Debon,
   Raul/0000-0001-9691-1906; Joven, Jorge/0000-0003-2749-4541; Martin
   Paredero, Vicente/0000-0002-2740-5847; Fernandez-Arroyo,
   Salvador/0000-0003-0147-1712; MENENDEZ MENENDEZ, JAVIER
   ABEL/0000-0001-8733-4561; Alonso-Villaverde, Carlos/0000-0001-8278-8388;
   Micol, Vicente/0000-0001-8089-0696; segura Carretero,
   Antonio/0000-0002-5564-5338; Rodriguez-Gallego,
   Esther/0000-0002-6363-2510
FU Universitat Rovira i Virgili; Fondo de Investigacion Sanitaria (FIS)
   [PI08/1032, PI08/1381, PI11/00130];  [IDI-20120741]; 
   [CIBER_CB12/03/30038];  [PROMETEO/2012/007]
FX The Unitat de Recerca Biomedica is currently being supported by the
   program of consolidated groups from the Universitat Rovira i Virgili and
   grants from the Fondo de Investigacion Sanitaria (FIS PI08/1032,
   PI08/1381 and PI11/00130). This and other laboratories involved in this
   study performed experiments in network under the bioactive food
   components platform, which share know-how, equipment and financial
   support (IDI-20120741, CIBER_CB12/03/30038 y PROMETEO/2012/007).
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NR 20
TC 56
Z9 57
U1 3
U2 35
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1613-4125
EI 1613-4133
J9 MOL NUTR FOOD RES
JI Mol. Nutr. Food Res.
PD JUN
PY 2014
VL 58
IS 6
BP 1374
EP 1378
DI 10.1002/mnfr.201300774
PG 5
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA AJ4XQ
UT WOS:000337683500022
PM 24668839
OA hybrid
DA 2025-06-11
ER

PT J
AU Lin, S
   Zhang, HQ
   Ma, AG
AF Lin, Song
   Zhang, Huaqi
   Ma, Aiguo
TI Association of gout and depression: A systematic review and
   meta-analysis
SO INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
LA English
DT Review
DE depression; gout; meta-analysis; mood disorder
ID US GENERAL-POPULATION; URIC-ACID; ERECTILE DYSFUNCTION; METABOLIC
   SYNDROME; HEALTH; LIFE; INTERLEUKIN-1-BETA; HYPERURICEMIA; MECHANISMS;
   DISORDERS
AB ObjectiveSeveral studies have shown that gout is associated with depression symptoms. In this study, a systematic review and meta-analysis was performed to explore the relationship between gout and depression.
   MethodsPublished articles were identified through a comprehensive review of PUBMED and EMBASE. Data from studies reporting relative risks, odds ratios, or hazard ratios comparing the risk of depression among participants who had gout versus those without gout were analyzed. A random-effect model was used to calculate pooled odds ratios and 95% confident intervals (CI).
   ResultsSeven studies, which included 411745 participants, aligned with our inclusion criteria and were included in the meta-analysis. Pooled analysis showed an association between gout and depression, with an odds ratio of 1.19 (95%CI, 1.11, 1.29; I-2=60.2%). Subgroup-analysis adjusted (or not) by study type or study quality showed a statistically significant association of gout and depression in all subgroups. Sensitivity analysis by 1-study removed analysis, excluding articles of self-reported gout assessment or male-only, confirmed the robustness of our results.
   ConclusionOur meta-analysis demonstrates a positive association between gout and depression. Further large-scale prospective cohort studies are needed to investigate the causality between gout and depression.
C1 [Lin, Song; Zhang, Huaqi; Ma, Aiguo] Qingdao Univ, Coll Publ Hlth, Qingdao, Shandong, Peoples R China.
C3 Qingdao University
RP Ma, AG (corresponding author), Qingdao Univ, Coll Publ Hlth, Qingdao, Shandong, Peoples R China.
EM magfood@qdu.edu.cn
RI Lin, Song/AAV-8739-2021
OI Lin, Song/0000-0002-7423-7217
FU National Natural Science Foundation of China [81373000]
FX National Natural Science Foundation of China, Grant/Award Number:
   81373000
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NR 40
TC 21
Z9 24
U1 3
U2 39
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0885-6230
EI 1099-1166
J9 INT J GERIATR PSYCH
JI Int. J. Geriatr. Psychiatr.
PD MAR
PY 2018
VL 33
IS 3
BP 441
EP 448
DI 10.1002/gps.4789
PG 8
WC Geriatrics & Gerontology; Gerontology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Psychiatry
GA FV8FH
UT WOS:000424820600001
PM 28921661
DA 2025-06-11
ER

PT J
AU Valtueña, S
   Del Rio, D
   Pellegrini, N
   Ardigò, D
   Franzini, L
   Salvatore, S
   Piatti, PM
   Riso, P
   Zavaroni, I
   Brighenti, F
AF Valtuena, S.
   Del Rio, D.
   Pellegrini, N.
   Ardigo, D.
   Franzini, L.
   Salvatore, S.
   Piatti, P. M.
   Riso, P.
   Zavaroni, I.
   Brighenti, F.
TI The total antioxidant capacity of the diet is an independent predictor
   of plasma β-carotene
SO EUROPEAN JOURNAL OF CLINICAL NUTRITION
LA English
DT Article
DE beta-carotene; antioxidants; diet; oxidative stress; insulin resistance;
   alcohol drinking
ID GAMMA-GLUTAMYL-TRANSFERASE; C-REACTIVE PROTEIN; SERUM CAROTENOIDS;
   CARDIOVASCULAR RISK; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   DIABETES-MELLITUS; TOCOPHEROLS; SUPPLEMENTATION; PROGRESSION
AB Objective: To investigate the contribution of the total antioxidant capacity (TAC) of the diet to plasma concentrations of beta-carotene.
   Design: Cross-sectional study.
   Setting: Department of Public Health and Department of Internal Medicine and Biomedical Sciences, University of Parma.
   Subjects: A total of 247 apparently healthy adult men (n = 140) and women (n = 107).
   Methods: A medical history, a physical exam including height, weight, waist circumference and blood pressure measurements, a fasting blood draw, an oral glucose tolerance test and a 3-day food record.
   Results: We observe a negative trend across quartiles of plasma beta-carotene for most biological variables clustering in the insulin resistance syndrome, as well as for traditional and new risk factors for type II diabetes and cardiovascular disease (CVD), including C-reactive protein and gamma-glutamyltranspeptidase (P < 0.05). Regarding dietary characteristics, energy-adjusted intake of fat, fiber, fruits, vegetables, beta-carotene, vitamin C, vitamin E and dietary TAC significantly increased with increasing plasma beta-carotene (P < 0.05), whereas alcohol intake decreased (P = 0.013). Adjusted geometric means (95% confidence interval) of plasma beta-carotene significantly increased across quartiles of dietary TAC, even when single dietary antioxidants were considered in the model (QI = 0.087 mg/dl (0.073 - 0.102); QII = 0.087 mg/dl (0.075 - 0.103); QIII = 0.114 mg/dl (0.098 - 0.132) and QIV = 0.110 mg/dl (0.093 - 0.130); P for linear trend = 0.026). When the population was divided on the basis of alcohol consumption, this trend was also observed in subjects drinking < 20 g alcohol/day (P = 0.034), but not in those with higher alcohol intake (P = 0.448).
   Conclusions: Dietary TAC is an independent predictor of plasma beta-carotene, especially in moderate alcohol drinkers. This may explain, at least in part, the inverse relationship observed between plasma beta-carotene and risk of chronic diseases associated to high levels of oxidative stress (i.e., diabetes and CVD), as well as the failure of beta-carotene supplements alone in reducing such risk.
C1 Univ Parma, Dept Internal Med & Biomed Sci, I-43100 Parma, Italy.
   Univ Parma, Dept Publ Hlth, I-43100 Parma, Italy.
   IRCCS, H San Raffaele, Cardiovasc & Metab Rehabil Unit, Milan, Italy.
   Univ Milan, Dept Food Sci & Microbiol, I-20122 Milan, Italy.
C3 University of Parma; University of Parma; Vita-Salute San Raffaele
   University; IRCCS Ospedale San Raffaele; University of Milan
RP Valtueña, S (corresponding author), Univ Parma, Dept Internal Med & Biomed Sci, Via Gramsci 14, I-43100 Parma, Italy.
EM valtuena@libero.it
RI Piatti, Piermarco/AAN-3115-2020; Riso, Patrizia/AAC-2072-2019; ARDIGO,
   DIEGO/AAD-5928-2022; Pellegrini, Nicoletta/F-5851-2010; Del Rio,
   Daniele/E-8696-2010; brighenti, furio/E-4174-2010
OI Ardigo, Diego/0000-0003-1127-7999; Riso, Patrizia/0000-0002-9204-7257;
   Del Rio, Daniele/0000-0001-5394-1259; brighenti,
   furio/0000-0001-8441-4611
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NR 41
TC 30
Z9 35
U1 0
U2 2
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0954-3007
EI 1476-5640
J9 EUR J CLIN NUTR
JI Eur. J. Clin. Nutr.
PD JAN
PY 2007
VL 61
IS 1
BP 69
EP 76
DI 10.1038/sj.ejcn.1602485
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 116VD
UT WOS:000242830700010
PM 16835597
DA 2025-06-11
ER

PT J
AU Açik, M
   Çakiroglu, FP
AF Acik, Murat
   Cakiroglu, Funda Pinar
TI Evaluating the Relationship between Inflammatory Load of a Diet and
   Depression in Young Adults
SO ECOLOGY OF FOOD AND NUTRITION
LA English
DT Article
DE Depression; dietary inflammatory index (DII); university students
ID SEGUIMIENTO-UNIVERSIDAD; METABOLIC SYNDROME; GUT MICROBIOTA; PATTERNS;
   INDEX; ASSOCIATION; MAGNESIUM; SYMPTOMS; MARKERS; FOLATE
AB The aim of this study is to investigate the relationship between dietary inflammatory index (DII) and depression. The study was carried out with 134 female university students staying in dormitory. The data were collected using questionnaire form. The questionnaire contains socio-demographic information, physical activity, anthropometric measurements, depression scale, and the 3-day food intake record. The DII score was calculated based on the food intake record form. It was found that 56 of the participants did not have any depression symptoms. The participants' mean DII scores were 0.76 +/- 0.59 and they were found to have a pro-inflammatory dietary pattern. The third-tertile depression score was 56.3 +/- 8.6, which was statistically higher than the others (p < 0.05). Upon modeling, a significant association between high DII scores and increased odds of incidence DepS was observed (odds ratio (OR) = 2.90; 95% CI = 1.51-5.98). Finally there is a need to conduct cohort studies to identify DII scores of the individuals in our country, investigate the relationship between these scores and depression, and establish a cause and effect relationship.
C1 [Acik, Murat; Cakiroglu, Funda Pinar] Ankara Univ, Dept Nutr & Dietet, Fac Hlth Sci, Aktas Neighborhood Plevne St 5 ALTINDAG, Ankara, Turkey.
C3 Ankara University
RP Açik, M (corresponding author), Ankara Univ, Dept Nutr & Dietet, Fac Hlth Sci, Aktas Neighborhood Plevne St 5 ALTINDAG, Ankara, Turkey.
EM acikm@ankara.edu.tr
RI Çakıroğlu, Funda/G-6628-2016; Açık, Murat/ADR-4371-2022
OI Acik, Murat/0000-0002-3104-6306; PINAR CAKIROGLU,
   FUNDA/0000-0003-2324-6874
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NR 39
TC 18
Z9 18
U1 1
U2 17
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 0367-0244
EI 1543-5237
J9 ECOL FOOD NUTR
JI Ecol. Food Nutr.
PD JUL 4
PY 2019
VL 58
IS 4
BP 366
EP 378
DI 10.1080/03670244.2019.1602043
EA APR 2019
PG 13
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA IQ1OD
UT WOS:000466071900001
PM 30987455
DA 2025-06-11
ER

PT J
AU Xie, JJ
   Wang, Y
AF Xie, Jiaji
   Wang, Yong
TI Multidisciplinary combined treatment based on bariatric surgery for
   metabolic syndrome: a review article
SO INTERNATIONAL JOURNAL OF SURGERY
LA English
DT Article
DE Bariatric surgery; metabolic syndrome; multidisciplinary diagnosis and
   treatment; obesity
ID Y GASTRIC BYPASS; TRANSORAL OUTLET REDUCTION; LAPAROSCOPIC SLEEVE
   GASTRECTOMY; COGNITIVE-BEHAVIORAL THERAPY; TYPE-2 DIABETES-MELLITUS;
   ARGON PLASMA COAGULATION; WEIGHT-LOSS MEDICATIONS; LONG-TERM OUTCOMES;
   QUALITY-OF-LIFE; GASTROJEJUNAL ANASTOMOSIS
AB As a chronic, multifactorial disease, obesity is associated with a global social and economic burden. This condition significantly affects normal daily life and healthy social interactions, and shortens the life expectancy of patients. Compared with traditional weight-loss methods, the emergence of bariatric surgery has effectively improved the management of obesity. Furthermore, bariatric surgery can also inhibit the progression of multiple metabolic diseases. Despite its potential advantages, bariatric surgery cannot completely eliminate the possibility of weight regain and inadequate weight loss following the procedure. For super-obese patients, bariatric surgery still remains a surgical risk. In addition, the psychological problems and poor eating habits of obese patients also affect the weight loss effect and daily life. Thus, various adjuvant therapies involving multiple disciplines have attracted people's attention. Recently, it has been recognized that the combination of multiple interventions based on bariatric surgery is more advantageous than a single intervention in alleviating the complex and diverse metabolic diseases associated with obesity. The combined therapy considerably enhances the long-term efficacy of bariatric surgery and plays a positive role in the mental health and social lives of patients. In this article, the authors review this multidisciplinary combination therapy to enhance the current understanding of the treatment of obesity.
C1 [Xie, Jiaji; Wang, Yong] China Med Univ, Affiliated Hosp 4, Ctr Bariatr & Metab Surg, 4 Chongshan East Rd, Shenyang 110000, Liaoning, Peoples R China.
C3 China Medical University
RP Wang, Y (corresponding author), China Med Univ, Affiliated Hosp 4, Ctr Bariatr & Metab Surg, 4 Chongshan East Rd, Shenyang 110000, Liaoning, Peoples R China.
EM 2210561050@qq.com; wangyong@cmu.edu.cn
FU Shenyang Young and Middle-aged Science and Technology Innovation Talent
   Support Program [RC200607]; Liaoning Province Livelihood Science and
   Technology Program Project [2021JH2/10300012]
FX Support for this article is provided by Shenyang Young and Middle-aged
   Science and Technology Innovation Talent Support Program (RC200607),
   Liaoning Province Livelihood Science and Technology Program Project
   (2021JH2/10300012). I am extremely grateful for the financial support of
   this article.
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NR 141
TC 1
Z9 1
U1 0
U2 1
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1743-9191
EI 1743-9159
J9 INT J SURG
JI Int. J. Surg.
PD JUN
PY 2024
VL 110
IS 6
BP 3666
EP 3679
DI 10.1097/JS9.0000000000001320
PG 14
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA UL4X2
UT WOS:001248212000090
PM 38489549
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Perez-Cornago, A
   Mansego, ML
   Zulet, MA
   Martinez, JA
AF Perez-Cornago, Aurora
   Mansego, Maria L.
   Angeles Zulet, Maria
   Alfredo Martinez, Jose
TI DNA Hypermethylation of the Serotonin Receptor Type-2A Gene Is
   Associated with a Worse Response to a Weight Loss Intervention in
   Subjects with Metabolic Syndrome
SO NUTRIENTS
LA English
DT Article
DE DNA methylation; HTR2A gene; obesity; metabolic syndrome; energy
   restriction; depressive symptoms; adiposity; epigenetics
ID OBESE SUBJECTS; METHYLATION; DEPRESSION; EXPRESSION; HTR2A; RISK;
   EPIGENETICS; SCHIZOPHRENIA; INFLAMMATION; POLYMORPHISM
AB Understanding the regulation of gene activities depending on DNA methylation has been the subject of much recent study. However, although polymorphisms of the HTR2A gene have been associated with both obesity and psychiatric disorders, the role of HTR2A gene methylation in these illnesses remains uncertain. The aim of this study was to evaluate the association of HTR2A gene promoter methylation levels in white blood cells (WBC) with obesity traits and depressive symptoms in individuals with metabolic syndrome (MetS) enrolled in a behavioural weight loss programme. Analyses were based on 41 volunteers (mean age 49 +/- 1 year) recruited within the RESMENA study. Depressive symptoms (as determined using the Beck Depression Inventory), anthropometric and biochemical measurements were analysed at the beginning and after six months of weight loss treatment. At baseline, DNA from WBC was isolated and cytosine methylation in the HTR2A gene promoter was quantified by a microarray approach. In the whole-study sample, a positive association of HTR2A gene methylation with waist circumference and insulin levels was detected at baseline. Obesity measures significantly improved after six months of dietary treatment, where a lower mean HTR2A gene methylation at baseline was associated with major reductions in body weight, BMI and fat mass after the treatment. Moreover, mean HTR2A gene methylation at baseline significantly predicted the decrease in depressive symptoms after the weight loss treatment. In conclusion, this study provides newer evidence that hypermethylation of the HTR2A gene in WBC at baseline is significantly associated with a worse response to a weight-loss intervention and with a lower decrease in depressive symptoms after the dietary treatment in subjects with MetS.
C1 [Perez-Cornago, Aurora; Mansego, Maria L.; Angeles Zulet, Maria; Alfredo Martinez, Jose] Univ Navarra, Ctr Nutr Res, Dept Nutr Food Sci & Physiol, Pamplona 31008, Spain.
   [Angeles Zulet, Maria; Alfredo Martinez, Jose] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr CIBERObn, Santiago De Compostela 15706, Spain.
C3 University of Navarra; CIBER - Centro de Investigacion Biomedica en Red;
   CIBEROBN; Instituto de Salud Carlos III
RP Martinez, JA (corresponding author), Univ Navarra, Ctr Nutr Res, Dept Nutr Food Sci & Physiol, C Irunlarrea 1, Pamplona 31008, Spain.
EM apcornago@alumni.unav.es; mlmansego@unav.es; mazulet@unav.es;
   jalfmtz@unav.es
RI Zulet, M. Angeles/H-1317-2017; Martinez Hernandez, J
   Alfredo/K-8709-2014; Perez-Cornago, Aurora/C-1097-2016; MANSEGO,
   MARIA/A-5687-2011
OI Zulet, M. Angeles/0000-0002-3926-0892; Martinez Hernandez, J
   Alfredo/0000-0001-5218-6941; Perez-Cornago, Aurora/0000-0002-5652-356X;
   MANSEGO, MARIA/0000-0001-8914-7890
FU Health Department of the Government of Navarra [48/2009]; Linea Especial
   about Nutrition, Obesity and Health (University of Navarra) [LE/97];
   Asociacion de Amigos Universidad de Navarra; Spanish Ministry of
   Economic and Competitiveness
FX This work was supported by Health Department of the Government of
   Navarra (48/2009) and the Linea Especial about Nutrition, Obesity and
   Health (University of Navarra LE/97). Also CIBERobn and RETICS schemes
   are gratefully credited. The pre-doctoral research grant to A. P. C.
   from the Asociacion de Amigos Universidad de Navarra is gratefully
   acknowledged. M.L.M. holds a Juan de la Cierva fellowship from Spanish
   Ministry of Economic and Competitiveness.
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NR 53
TC 20
Z9 27
U1 0
U2 10
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JUN
PY 2014
VL 6
IS 6
BP 2387
EP 2403
DI 10.3390/nu6062387
PG 17
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA AK1RA
UT WOS:000338192000020
PM 24959950
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Parabiaghi, A
   Tettamanti, M
   D'Avanzo, B
   Barbato, A
AF Parabiaghi, A.
   Tettamanti, M.
   D'Avanzo, B.
   Barbato, A.
CA GiSAS Study Grp
TI Metabolic syndrome and drug discontinuation in schizophrenia: a
   randomized trial comparing aripiprazole olanzapine and haloperidol
SO ACTA PSYCHIATRICA SCANDINAVICA
LA English
DT Article
DE antipsychotic drugs; adverse effects; clinical trial; effectiveness
ID CORONARY-HEART-DISEASE; DOUBLE-BLIND; ANTIPSYCHOTIC-DRUGS; ATYPICAL
   ANTIPSYCHOTICS; 1ST-EPISODE PSYCHOSIS; WEIGHT-GAIN; DISORDER; RISK;
   RISPERIDONE; QUETIAPINE
AB Objective: To determine whether the prescription of aripiprazole, compared with olanzapine and haloperidol, was associated with a lower frequency of metabolic syndrome (MS) and treatment discontinuation at 1 year.
   Method: Patients were randomly assigned to be treated open-label and according to usual clinical practice with either aripiprazole, olanzapine, or haloperidol and followed up for 1 year.
   Results: Three hundred out-patients with persistent schizophrenia were recruited in 35 mental health services. The intention-to-treat (ITT) analysis found no significant differences in the rate of MS between aripiprazole (37%), olanzapine (47%), and haloperidol (42%). Treatment discontinuation for any cause was higher for aripiprazole (52%) than for olanzapine (33%; OR, 0.41; P = 0.004), or haloperidol (37%; OR, 0.51; P = 0.030). No significant difference was found between olanzapine and haloperidol. Time to discontinuation for any cause was longer for olanzapine than for aripiprazole (HR, 0.55; P < 0.001). No significant differences were found between haloperidol and aripiprazole, or between olanzapine and haloperidol.
   Conclusion: The prescription of aripiprazole did not significantly reduce the rates of MS, but its treatment retention was worse. Aripiprazole cannot be considered the safest and most effective drug for maintenance treatment of schizophrenia in routine care, although it may have a place in antipsychotic therapy.
C1 [Parabiaghi, A.; Tettamanti, M.; D'Avanzo, B.; Barbato, A.; GiSAS Study Grp] IRCCS Ist Ric Farmacol Mario Negri, I-20156 Milan, Italy.
C3 Istituto di Ricerche Farmacologiche Mario Negri IRCCS
RP Barbato, A (corresponding author), IRCCS Ist Ric Farmacol Mario Negri, Lab Epidemiol & Social Psychiat, Dept Neurosci, Via La Masa 19, I-20156 Milan, Italy.
EM angelo.barbato@marionegri.it
RI D'Avanzo, Barbara/AAA-7654-2020; Tettamanti, Mauro/U-8925-2017
OI Casacchia, Massimo/0000-0003-1015-3919; BIGNOTTI,
   STEFANO/0000-0002-7840-9637; Barbato, Angelo/0000-0001-7142-700X;
   Tettamanti, Mauro/0000-0001-7345-0887; d'avanzo,
   barbara/0000-0002-0361-7263; Cannavo, Dario/0000-0001-9423-1747
FU IRCCS-Istituto di Ricerche Farmacologiche 'Mario Negri', a non-profit
   research foundation; Bristol-Myers Squibb (BMS)
FX The IRCCS-Istituto di Ricerche Farmacologiche 'Mario Negri', a
   non-profit research foundation, acted as study sponsor and directly
   contributed to funding. Bristol-Myers Squibb (BMS) gave an unrestricted
   grant accepted on the basis of a contract that ensured full independence
   and data property. On the basis of accountable criteria of independence,
   the trial was approved by the central review board of the Local Health
   Agency of Genoa (reference 49549, March 2007) as an independent study
   aimed at improving health care, according to the definition of the
   Italian Ministerial Act 17 December 2004. This allowed the NHS to cover
   the costs of drugs, assessments, and insurance. The funders had no
   direct involvement in the study design, data collection, analysis and
   interpretation, writing reports, or submitting for publication.
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NR 49
TC 18
Z9 19
U1 0
U2 13
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0001-690X
EI 1600-0447
J9 ACTA PSYCHIAT SCAND
JI Acta Psychiatr. Scand.
PD JAN
PY 2016
VL 133
IS 1
BP 63
EP 75
DI 10.1111/acps.12468
PG 13
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA DA7RN
UT WOS:000368001900007
PM 26252780
DA 2025-06-11
ER

PT J
AU Lugnier, C
AF Lugnier, Claire
TI PDE inhibitors: a new approach to treat metabolic syndrome?
SO CURRENT OPINION IN PHARMACOLOGY
LA English
DT Article
ID CYCLIC-NUCLEOTIDE PHOSPHODIESTERASES; NECROSIS-FACTOR-ALPHA; ACTIVATED
   PROTEIN-KINASE; STIMULATES LEYDIG-CELL; SMOOTH-MUSCLE-CELLS;
   INSULIN-SECRETION; SELECTIVE-INHIBITION; HUMAN ADIPOCYTES; AMP
   PHOSPHODIESTERASES; SYNAPTIC PLASTICITY
AB About one third of people in the world suffer from metabolic syndrome (MetS), with symptoms such as hypertension and elevated blood cholesterol, and with increased risk of developing additional diseases such as diabetes mellitus and heart disease. The progression of this multifactorial pathology, which targets various tissues and organs, might necessitate a renewal in therapeutic approaches. Since cyclic nucleotide phosphodiesterases (PDEs), enzymes which hydrolyze cyclic AMP and cyclic GMP, play a crucial role in regulating endocrine and cardiovascular functions, inflammation, oxidative stress, and cell proliferation, all of which contribute to MetS, we wonder whether PDE inhibitors might represent new therapeutic approaches for preventing and treating MetS.
C1 Univ Strasbourg, Fac Pharm, Lab Biophoton & Pharmacol, CNRS,UMR 7213, F-67401 Illkirch Graffenstaden, France.
C3 Universites de Strasbourg Etablissements Associes; Universite de
   Strasbourg; Centre National de la Recherche Scientifique (CNRS); CNRS -
   National Institute for Biology (INSB)
RP Lugnier, C (corresponding author), Univ Strasbourg, Fac Pharm, Lab Biophoton & Pharmacol, CNRS,UMR 7213, 74 Route Rhin, F-67401 Illkirch Graffenstaden, France.
EM claire.lugnier@unistra.fr
RI Lugnier, Claire/AAF-3911-2020
OI Lugnier, Claire/0000-0002-0850-1331
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NR 97
TC 27
Z9 28
U1 0
U2 8
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1471-4892
EI 1471-4973
J9 CURR OPIN PHARMACOL
JI Curr. Opin. Pharmacol.
PD DEC
PY 2011
VL 11
IS 6
BP 698
EP 706
DI 10.1016/j.coph.2011.09.012
PG 9
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 868KX
UT WOS:000298523300021
PM 22018840
DA 2025-06-11
ER

PT J
AU Roriz-Cruz, M
   Rosset, I
   Wada, T
   Sakagami, T
   Ishine, M
   Roriz, JD
   Cruz, TRS
   Hosseinkhani, M
   Rodrigues, RP
   Sudoh, S
   Arai, H
   Wakatsuki, Y
   Souza, AC
   Nakagawa, M
   Kita, T
   Matsubayashi, K
AF Roriz-Cruz, Matheus
   Rosset, Idiane
   Wada, Taizo
   Sakagami, Teiji
   Ishine, Masayuki
   Roriz-Filho, Jarbas De Sa
   Cruz, Thadeu R. S.
   Hosseinkhani, Mohsen
   Rodrigues, Rosalina P.
   Sudoh, Shinji
   Arai, Hidenori
   Wakatsuki, Yoshio
   Souza, Antonio C.
   Nakagawa, Masanori
   Kita, Toru
   Matsubayashi, Kozo
TI Cognitive impairment and frontal-subcortical geriatric syndrome are
   associated with metabolic syndrome in a stroke-free population
SO NEUROBIOLOGY OF AGING
LA English
DT Article
DE frontal-subcortical; metabolic syndrome; successful aging; cognitive
   impairment; vascular depression; executive dysfunction; neuromotor
   dysfunction; urgency-type incontinence; elderly; Brazil
ID WHITE-MATTER HYPERINTENSITIES; SILENT BRAIN INFARCTION;
   ALZHEIMERS-DISEASE; INSULIN-RESISTANCE; PARKINSONS-DISEASE;
   RISK-FACTORS; FUNCTIONAL DECLINE; VASCULAR DEMENTIA; GLOBAL BURDEN;
   FOLLOW-UP
AB Background: Metabolic syndrome (Met.S) consists of a conglomeration of obesity, hypertension, glucose intolerance, and dislipidemia. Frontal-subcortical geriatric syndrome (FSCS) is caused by ischemic disruption of the frontal-subcortical network. It is unknown if Met.S is associated with FSCS.
   Methods: We evaluated 422 community-dwelling elderly (>= 60) in Brazil. FSCS was defined as the presence of at least one frontal release sign (grasping, palmomental, snout, or glabellar) plus coexistence of >= 3 the following criteria: (1) cognitive impairment, (2) late-onset depression, (3) neuromotor dysfunction, and (4) urgency incontinence. All values were adjusted to age and gender.
   Results: Met.S was present in 39.3% of all subjects. Cases without any of the FSCS components represented 37.2% ('successful neuroaging' group). People with 1-3 of the FSCS components ('borderline pathological neuroaging' group) were majority (52.6%), whereas those with 4-5 of these components (FSCS group) were minority (10.2%). Met.S was significantly associated with FSCS (OR= 5.9; Cl: 1.5-23.4) and cognitive impairment (OR = 2.2; Cl: 1.1-4.6) among stroke-free subjects. Number of Met.S components explained 30.7% of the variance on the number of FSCS criteria (P < 0.001). If Met.S were theoretically removed from this population, prevalence of FSCS would decline by 31.6% and that of cognitive impairment by 21.4%.
   Conclusions: Met.S was significantly associated with a 5.9 and 2.2 times higher chance of FSCS and cognitive impairment, respectively. Met.S might be a major determinant of 'successful' or 'pathological' neuroaging in western societies. (c) 2006 Elsevier Inc. All rights reserved.
C1 Kyoto Univ, Dept Neurol, Kyoto, Japan.
   Kyoto Univ, Dept Geriatr, Kyoto, Japan.
   Kyoto Prefectural Univ, Res Inst Neurosci Aging, Kyoto 606, Japan.
   Kyoto Prefectural Univ, Dept Neurol, Div Geriatr Neurol, Kyoto 606, Japan.
   Kyoto Univ, Dept Psychiat, Div Geriatr Neuropsychiat, Kyoto, Japan.
   Univ Sao Paulo, Dept Geriatr, Sao Paulo, Brazil.
   Univ Sao Paulo, Dept Gerontol Nursing, Sao Paulo, Brazil.
   CESMAC, Fac Odontol, Maceio, Brazil.
   Kyoto Univ, Dept Cardiol, Kyoto, Japan.
   Kyoto Univ, Dept Field Med, Kyoto, Japan.
C3 Kyoto University; Kyoto University; Kyoto Prefectural University; Kyoto
   Prefectural University; Kyoto University; Universidade de Sao Paulo;
   Universidade de Sao Paulo; Kyoto University; Kyoto University
RP Roriz-Cruz, M (corresponding author), Kyoto Univ Hosp, Dept Neurol, 4th Floor,54 Kawahara Cho, Kyoto, Shogoin, Japan.
EM matheusroriz@hotmail.com
RI Sousa, Luísa/JDW-2290-2023; Rodrigues, Rosalina/C-5714-2013; da Cruz;
   Manica da Cruz, Ivana/G-4329-2012; Arai, Hidenori/P-9816-2017
OI da Cruz; Manica da Cruz, Ivana/0000-0003-3008-6899; Roriz Filho,
   Jarbas/0000-0002-5928-0399; Arai, Hidenori/0000-0002-9000-6849;
   Rodrigues, Rosalina Aparecida Partezani/0000-0001-8916-1078
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NR 94
TC 46
Z9 50
U1 0
U2 8
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0197-4580
EI 1558-1497
J9 NEUROBIOL AGING
JI Neurobiol. Aging
PD NOV
PY 2007
VL 28
IS 11
BP 1723
EP 1736
DI 10.1016/j.neurobiolaging.2006.07.013
PG 14
WC Geriatrics & Gerontology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology; Neurosciences & Neurology
GA 217KI
UT WOS:000249946400011
PM 16962212
DA 2025-06-11
ER

PT J
AU Chiang, LC
   Heitkemper, MM
   Chiang, SL
   Tzeng, WC
   Lee, MS
   Hung, YJ
   Lin, CH
AF Chiang, Li-Chi
   Heitkemper, Margaret McLean
   Chiang, Shang-Lin
   Tzeng, Wen-Chii
   Lee, Meei-Shyuan
   Hung, Yi-Jen
   Lin, Chia-Huei
TI Motivational Counseling to Reduce Sedentary Behaviors and Depressive
   Symptoms and Improve Health-Related Quality of Life Among Women With
   Metabolic Syndrome
SO JOURNAL OF CARDIOVASCULAR NURSING
LA English
DT Article
DE depression; health-related quality of life; motivational interviewing;
   sedentary behavior; women
ID RANDOMIZED CONTROLLED-TRIAL; ALL-CAUSE MORTALITY; MIDDLE-AGED WOMEN;
   PHYSICAL-ACTIVITY; CARDIOVASCULAR-DISEASE; RISK; TIME; EPIDEMIOLOGY;
   METAANALYSIS; ASSOCIATION
AB Background: Motivational interviewing, as a counseling approach, could promote not only behavioral changes but also individuals psychological adaptation. Previous studies provide evidence that motivational interviewing focused on increasing physical activity decreases the risk of metabolic syndrome in women. Its effects on sedentary behaviors, depressive symptoms, and health-related quality of life (HRQL) remain unknown. Objectives: The aim of this study was to evaluate whether a 12-week motivational counseling program reduces sedentary behaviors and depressive symptoms and improves HRQL in Taiwanese women. Methods: A randomized controlled study was conducted. Participants (n = 115) were randomly assigned into 3 groups: experimental group (received a brochure on lifestyle modification combined with 12 weeks of motivational counseling), comparison group (received a lifestyle modification brochure), and usual care group (UCG). Outcome variables were measured at baseline and at 12 weeks post intervention by the International Physical Activity Questionnaire, Beck Depression Inventory, and Medical Outcomes Short Form-36 Health Survey. Generalized estimating equations were applied to analyze the intervention effects of groups by interaction of group and time. Results: Women in the experimental group not only reduced (P <.001) weekly sitting time by 374 minutes but also decreased (P <.05) depressive symptoms, as well as had greater overall HRQL including 8 subscales as compared with the UCG. As compared with the UCG, the women in the comparison group had no change in sedentary behaviors, but they had reduced depressive symptoms and improvement on some HRQL subscales. Conclusions: Motivational counseling that incorporates behavioral change principles is effective in reducing sedentary behaviors and depressive symptoms and improving HRQL for women with metabolic syndrome.
C1 [Chiang, Li-Chi] China Med Univ, Sch Nursing, Taichung, Taiwan.
   [Chiang, Li-Chi; Tzeng, Wen-Chii; Lin, Chia-Huei] Natl Def Med Ctr, Sch Nursing, Taipei, Taiwan.
   [Chiang, Li-Chi; Lee, Meei-Shyuan] Natl Def Med Ctr, Grad Inst Med Sci, Taipei, Taiwan.
   [Heitkemper, Margaret McLean] Univ Washington, Sch Med, Dept Biobehav Nursing & Hlth Syst, Seattle, WA USA.
   [Heitkemper, Margaret McLean] Univ Washington, Sch Med, Div Gastroenterol, Seattle, WA USA.
   [Chiang, Shang-Lin; Hung, Yi-Jen; Lin, Chia-Huei] Natl Def Med Ctr, Sch Med, Taipei, Taiwan.
   [Chiang, Shang-Lin] Triserv Gen Hosp, Dept Phys Med & Rehabil, Taipei, Taiwan.
   [Lee, Meei-Shyuan] Natl Def Med Ctr, Sch Publ Hlth, Taipei, Taiwan.
   [Hung, Yi-Jen] Triserv Gen Hosp, Songshan Branch, Taipei, Taiwan.
   [Lin, Chia-Huei] Triserv Gen Hosp, Dept Nursing, Songshan Branch, Taipei, Taiwan.
C3 China Medical University Taiwan; National Defense Medical Center;
   National Defense Medical Center; University of Washington; University of
   Washington Seattle; University of Washington; University of Washington
   Seattle; National Defense Medical Center; Tri-Service General Hospital;
   National Defense Medical Center; Tri-Service General Hospital;
   Tri-Service General Hospital
RP Lin, CH (corresponding author), Natl Def Med Ctr, 161 Sec 6 Mingchuan E Rd, Taipei 114, Taiwan.
EM andyy520@mail.ndmctsgh.edu.tw
RI Lin, Chia-Huei/GLQ-5499-2022; Chiang, Li-Chi/AAW-9661-2020; Tzeng,
   Wen-Chii/M-4214-2014
OI Chiang, Li-Chi/0000-0002-6383-7495; Tzeng, Wen-Chii/0000-0002-4205-896X;
   Lin, Chia-Huei/0000-0003-3751-602X; Lin, Chia-Huei/0000-0002-5557-9668
FU Tri-Service General Hospital [TSGHC102-138]; Ministry of Science and
   Technology, Taipei, Taiwan [MOST107-2314-B016-068]
FX We thank all of the participating women in this study funded by the
   Tri-Service General Hospital (TSGHC102-138) and theMinistry of Science
   and Technology (MOST107-2314-B016-068), Taipei, Taiwan.
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NR 53
TC 17
Z9 17
U1 2
U2 14
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0889-4655
EI 1550-5049
J9 J CARDIOVASC NURS
JI J. Cardiovasc. Nurs.
PD JUL-AUG
PY 2019
VL 34
IS 4
BP 327
EP 335
DI 10.1097/JCN.0000000000000573
PG 9
WC Cardiac & Cardiovascular Systems; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Cardiovascular System & Cardiology; Nursing
GA IQ5OJ
UT WOS:000480801800010
PM 30920439
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Gentile, C
   Starnino, L
   Dupuis, G
   D'Antono, B
AF Gentile, Christina
   Starnino, Louisia
   Dupuis, Gilles
   D'Antono, Bianca
TI Mindfulness-Based Stress Reduction in Older Adults at Risk for Coronary
   Artery Disease: A Pilot Randomized Trial
SO CLINICAL GERONTOLOGIST
LA English
DT Article
DE Aging; mindfulness; clinical trial; stress; cholesterol; MBSR;
   acceptability; feasibility; metabolic syndrome; autonomic stress
   responses
AB Objectives: Stress influences metabolic activity and increases risk for cardiovascular disease (CVD). We sought to a) examine feasibility and acceptability of mindfulness-based stress reduction (MBSR) in older adults at risk for CVD, and b) obtain preliminary data on its metabolic impact.
   Methods: A pilot RCT was conducted using a pre-post, 2-month follow-up design. Eighty-one individuals with metabolic syndrome and non-normative responses to stress in a previous investigation were invited. Participants were randomized (by sex and stress response) to a 9-week MBSR or a wait-list control group. Feasibility and acceptability were assessed and blood assayed. Between-subjects (MBSR vs waitlist control) ANOVAs on metabolic parameter change scores, and one-way repeated measures ANOVAs (pre-, post-, follow-up) were performed.
   Results: Thirty-three individuals (41%) responded to invitations, 26 were interested, of whom 19 were randomized (M-age = 67 years, SD = 7.70). Completion rate of MBSR was 72% and overall attendance was 96%. Reported benefits included increased relaxation, greater interpersonal connection, and increased body awareness. MBSR led to a decrease of 15% in LDL cholesterol and 10% in total cholesterol versus 4.5% and 1%, respectively, in the waitlist. Within group analyses showed notable decreases in LDL, triglycerides, and waist circumference post-MBSR and 2 months later.
   Conclusions: A RCT was largely feasible and MBSR acceptable to participants. MBSR may lead to sustained decreases in cholesterol levels, warranting development of large-scale research on this topic.
   Clinical Implications: Given the role of stress in CVD, addition of stress management interventions may serve as a useful complement to risk management among older individuals.
C1 [Gentile, Christina; Starnino, Louisia; D'Antono, Bianca] Montreal Heart Inst, Res Ctr, 5000 Belanger Est, Montreal, PQ H1T 1C8, Canada.
   [Starnino, Louisia; Dupuis, Gilles] Univ Quebec Montreal, Psychol Dept, Montreal, PQ, Canada.
   [D'Antono, Bianca] Univ Quebec Montreal, Psychol, Montreal, PQ, Canada.
C3 Universite de Montreal; University of Quebec; University of Quebec
   Montreal; University of Quebec; University of Quebec Montreal
RP D'Antono, B (corresponding author), Montreal Heart Inst, Res Ctr, 5000 Belanger Est, Montreal, PQ H1T 1C8, Canada.
EM bianca.d.antono@umontreal.ca
FU Canadian Institutes of Health Research [CIHR -MOP] [111015]; Montreal
   Heart Foundation; Fonds de la recherche en sante du Quebec (FRSQ);
   Academy of Finland (AKA) [111015] Funding Source: Academy of Finland
   (AKA)
FX This study was supported by grants awarded to Dr. D'Antono by the
   Canadian Institutes of Health Research [CIHR -MOP #111015] and the
   Montreal Heart Foundation. A dedicated donation was offered to Bianca
   D'Antono by Ordre Fraternal des Aigles 3176 Inc (St-Jerome). Christina
   Gentile and Louisia Starnino were supported by the Doctoral Training
   Award issued by the Fonds de la recherche en sante du Quebec (FRSQ). The
   funding sources had no involvement in this study. No additional funding
   was received
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NR 47
TC 4
Z9 4
U1 2
U2 13
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 0731-7115
EI 1545-2301
J9 CLIN GERONTOLOGIST
JI Clin. Gerontol.
PD MAR 15
PY 2022
VL 45
IS 2
BP 272
EP 286
DI 10.1080/07317115.2021.1887421
EA MAR 2021
PG 15
WC Geriatrics & Gerontology; Gerontology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Psychiatry
GA ZJ3JC
UT WOS:000629045100001
PM 33719899
OA hybrid
DA 2025-06-11
ER

PT J
AU Duke, NN
   Jensen, TM
   Perreira, KM
   Hotz, VJ
   Harris, KM
AF Duke, Naomi N.
   Jensen, Todd M.
   Perreira, Krista M.
   Hotz, V. Joseph
   Harris, Kathleen Mullan
TI The Role of Family Health History in Predicting Midlife Chronic Disease
   Outcomes
SO AMERICAN JOURNAL OF PREVENTIVE MEDICINE
LA English
DT Article
ID CORONARY-HEART-DISEASE; CARDIOVASCULAR RISK-FACTORS; MIDDLE-AGED ADULTS;
   MYOCARDIAL-INFARCTION; PARENTAL-HISTORY; CANCER; POPULATION;
   SURVEILLANCE; DEATH; HUNT
AB Introduction: The generational relevance for determining disease risk for the leading causes of morbidity and mortality for U.S. adults is a source of debate.
   Methods: Data on 12,300 adults (Add Health Study Members) participating in Wave V (2016-2018) of the National Longitudinal Study of Adolescent to Adult Health (also known as Add Health) were merged with data from respondents' parents (n=2,013) participating in the Add Health Parent Study (2015-2017). Analyses beginning in January 2020 examined the concordance in lifetime occurrence of chronic conditions across 4 generations, including cardiovascular disease, diabetes, hypertension, hyperlipidemia, obesity, cancer, and depression and examined the associations between individual disease history and ones' family health history for the same condition.
   Results: Mean ages were 37.4 years for Add Health Study Members and 62.9 years for Add Health Parent Study mothers. The histories of mothers from the Add Health Parent Study on hyperlipidemia (AOR=1.61, 95% CI=1.04, 2.48), obesity (AOR=1.77, 95% CI=1.27, 2.48), and depression (AOR=1.87, 95% CI=1.19, 2.95) were significantly associated with increased odds of Add Health Study Member report of these conditions. Maternal great grandparent hyperlipidemia history was significantly associated with the Add Health Study Member hyperlipidemia (AOR=2.81, 95% CI=1.51, 5.21). Histories of diabetes in maternal grandfather (AOR=2.41, 95% CI=1.24, 4.69) and maternal great grandparent (AOR=3.05, 95% CI=1.45, 6.43) were significantly associated with Add Health Study Member diabetes. Each additional point in the Add Health Parent Study mothers' cardiometabolic risk factor index was associated with an 11% increase (incidence rate ratio=1.11, 95% CI=1.04, 1.19) in the expected count of cardiometabolic risk conditions for the Add Health Study Members.
   Conclusions: Multigenerational health histories have value for quantifying the probability of diabetes, obesity, depression, and hyperlipidemia in early mid-adulthood. Family health history knowledge is relevant for health promotion and disease prevention strategies. (C) 2021 American Journal of Preventive Medicine. Published by Elsevier Inc. All rights reserved.
C1 [Duke, Naomi N.] Duke Univ, Duke Dept Pediat, Div Gen Pediat & Adolescent Hlth, Durham, NC 27705 USA.
   [Duke, Naomi N.] Duke Univ, Duke Ctr Childhood Obes Res DCCOR, Durham, NC 27705 USA.
   [Duke, Naomi N.] Duke Univ, Dept Sociol, Durham, NC 27705 USA.
   [Jensen, Todd M.] Univ N Carolina, Sch Social Work, Chapel Hill, NC 27515 USA.
   [Perreira, Krista M.] Univ N Carolina, Dept Social Med, Chapel Hill, NC 27515 USA.
   [Hotz, V. Joseph] Duke Univ, Dept Econ, Durham, NC 27705 USA.
   [Harris, Kathleen Mullan] Univ N Carolina, Carolina Populat Ctr, Chapel Hill, NC 27515 USA.
   [Harris, Kathleen Mullan] Univ N Carolina, Dept Sociol, Chapel Hill, NC 27515 USA.
C3 Duke University; Duke University; Duke University; University of North
   Carolina; University of North Carolina Chapel Hill; University of North
   Carolina; University of North Carolina Chapel Hill; Duke University;
   University of North Carolina; University of North Carolina Chapel Hill;
   University of North Carolina; University of North Carolina Chapel Hill
RP Duke, NN (corresponding author), Duke Univ, Med Ctr, Dept Pediat, Box 3675 DUMC,Civitan Bldg,2213 Elba St, Durham, NC 27705 USA.
EM naomi.duke@duke.edu
RI Jensen, Todd/AAG-9020-2019
OI Perreira, Krista/0000-0003-2906-0261
FU Eunice Kennedy Shriver National Institute of Child Health and Human
   Development [P01-HD31921]; National Institute on Aging [R01-AG042794]
FX This research uses data from Add Health, a program project directed by
   Kathleen Mullan Harris and designed by J. Richard Udry, Peter S.
   Bearman, and Kathleen Mullan Harris at the University of North Carolina
   at Chapel Hill and funded by Grant P01-HD31921 from the Eunice Kennedy
   Shriver National Institute of Child Health and Human Development, with
   cooperative funding from 23 other federal agencies and foundations.
   Information on how to obtain the Add Health data files is available on
   the Add Health website (www.cpc.unc.edu/addhealth).The research also
   used data from the Add Health Parent Study directed by V. Joseph Hotz
   and Kathleen Mullan Harris and funded by Grant R01-AG042794 from the
   National Institute on Aging.
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NR 57
TC 8
Z9 9
U1 1
U2 5
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0749-3797
EI 1873-2607
J9 AM J PREV MED
JI Am. J. Prev. Med.
PD OCT
PY 2021
VL 61
IS 4
BP 509
EP 517
DI 10.1016/j.amepre.2021.02.021
EA SEP 2021
PG 9
WC Public, Environmental & Occupational Health; Medicine, General &
   Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; General & Internal Medicine
GA WC6RP
UT WOS:000704383600016
PM 34229928
OA Green Submitted, Green Accepted
DA 2025-06-11
ER

PT B
AU Loebel, A
   Xu, J
   Hsu, J
   Cucchiaro, J
   Pikalov, A
AF Loebel, Antony
   Xu, Jane
   Hsu, Jay
   Cucchiaro, Josephine
   Pikalov, Andrei
GP NY Acad Sci
TI The development of lurasidone for bipolar depression
SO PHARMACEUTICAL SCIENCE TO IMPROVE THE HUMAN CONDITION: PRIX GALIEN 2014
SE Annals of the New York Academy of Sciences-Series
LA English
DT Article; Book Chapter
DE bipolar disorder; major depressive episode; atypical antipsychotic;
   lurasidone
ID DOUBLE-BLIND; I DEPRESSION; METABOLIC SYNDROME; DISORDER; SCHIZOPHRENIA;
   5-HT7; MONOTHERAPY; PREVALENCE; MORTALITY; 6-WEEK
AB Bipolar disorder is a chronic, recurrent illness that ranks among the top 10 causes of disability in the developed world. As the illness progresses, major depressive episodes increasingly predominate. However, few treatment options are available that have demonstrated efficacy in the treatment of bipolar depression, either as monotherapy or adjunctive therapy in combination with mood stabilizers. Lurasidone is an atypical antipsychotic drug that was initially developed for the treatment of schizophrenia. Since no previous atypical antipsychotic development program had proceeded directly from work on schizophrenia to bipolar depression, the decision to focus on this indication represented an innovation in central nervous system drug development and was designed to address a clinically significant unmet need. The current review summarizes key results of a clinical development program undertaken to characterize the efficacy and safety of lurasidone in patients diagnosed with bipolar depression. Lurasidone is currently the only treatment for bipolar depression approved in the United States as both a monotherapy and an adjunctive therapy with lithium or valproate. The approval of lurasidone expands available treatment options for patients with bipolar depression and provides a therapy with an overall favorable risk-benefit profile.
C1 Sunov Pharmaceut Inc, Ft Lee, NJ USA.
   [Loebel, Antony] Sunov Pharmaceut Inc, 84 Waterford Dr, Marlborough, MA 01752 USA.
C3 Dainippon Sumitomo Pharmaceutical Company; Sunovion Pharmaceuticals
   Inc.; Dainippon Sumitomo Pharmaceutical Company; Sunovion
   Pharmaceuticals Inc.
RP Loebel, A (corresponding author), Sunov Pharmaceut Inc, 84 Waterford Dr, Marlborough, MA 01752 USA.
EM antony.loebel@sunovion.com
RI Rajagopalan, Krithika/AAZ-7034-2021
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NR 55
TC 13
Z9 13
U1 1
U2 6
PU BLACKWELL SCIENCE PUBL
PI OXFORD
PA OSNEY MEAD, OXFORD OX2 0EL, ENGLAND
J9 ANN NY ACAD SCI
JI Ann.NY Acad.Sci.
PY 2015
VL 1358
BP 95
EP 104
DI 10.1111/nyas.12965
PG 10
WC Pharmacology & Pharmacy
WE Book Citation Index – Science (BKCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA BE2SY
UT WOS:000369996200008
PM 26771990
OA hybrid
DA 2025-06-11
ER

PT J
AU Dessein, PH
   Christian, BF
   Woodiwiss, AJ
   Norton, GR
   Solomon, A
AF Dessein, P. H.
   Christian, B. F.
   Woodiwiss, A. J.
   Norton, G. R.
   Solomon, A.
TI Public healthcare attendance associates with enhanced conventional and
   non-conventional atherosclerotic cardiovascular disease risk burdens in
   established rheumatoid arthritis
SO CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
LA English
DT Article
DE Atherosclerotic cardiovascular disease risk; public healthcare
   attendance; socioeconomic disadvantage; rheumatoid arthritis
ID MYOCARDIAL-INFARCTION; METABOLIC SYNDROME; SUBCLINICAL ATHEROSCLEROSIS;
   MORTALITY; EVENTS; DETERMINANTS; PREVALENCE; CONTRIBUTE; INSURANCE
AB Objective
   To assess whether public healthcare attendance associates with altered atherosclerotic cardiovascular disease risk in established rheumatoid arthritis (RA).
   Methods
   We determined disparities in major conventional (hypertension, dyslipidemia, smoking and diabetes), other conventional (underweight, obesity, metabolic syndrome, chronic kidney disease, alcohol use, tension, depression and body height) and non-conventional (current and cumulative inflammation markers) cardiovascular risk factors between 424 consecutive public and 202 private healthcare patients in mixed regression models.
   Results
   Eighty-one percent of public healthcare patients were black (67%) or caucasian (14%) and 83% of private healthcare cases were caucasian. Seventy percent of the patients had >= 1 major conventional risk factor. After adjustment for age, gender, ethnic origin and statin use when appropriate, public healthcare attendance associated with the prevalence of hypertension (odds ratio (OR) [95%CI]=1.72 [1.03, 2.85]), having >= 1 major conventional risk factor (OR [95%CI]=1.83 [1.09, 3.07]) and an increased mean (SD) number of such risk factors (p=0.03), metabolic syndrome frequency (OR [95%CI]=1.90 [1.07, 3.40]), alcohol use (OR [95%CI]=0.07 [0.03, 0.18]), shorter stature (p<0.0001), higher tension (p=0.02) and depression score (p<0.0001) and higher inflammatory markers including the disease activity score in 28 joints (p=0.005), C-reactive protein concentration (p=0.0006), Health Assessment Questionnaire disability index (p<0.0001), and number of deformed joints (p<0.0001). In sensitivity analyses performed in caucasian Africans, public healthcare attendance associated with increased frequencies of each major conventional risk factor (OR=2.06 to 3.69) and higher other conventional and non-conventional mediated cardiovascular risk.
   Conclusion
   Public healthcare patients with established RA experience markedly enhanced conventional and non-conventional cardiovascular risk burdens.
C1 [Dessein, P. H.; Christian, B. F.; Solomon, A.] Univ Witwatersrand, Dept Rheumatol, Johannesburg, South Africa.
   [Dessein, P. H.; Christian, B. F.; Solomon, A.] Charlotte Maxeke Johannesburg Acad Hosp, Johannesburg, South Africa.
   [Woodiwiss, A. J.; Norton, G. R.] Univ Witwatersrand, Cardiovasc Pathophysiol & Genom Res Unit, Sch Physiol, Fac Hlth Sci, Johannesburg, South Africa.
C3 University of Witwatersrand; University of Witwatersrand; Johannesburg
   Academy Hospital; University of Witwatersrand
RP Dessein, PH (corresponding author), POB 1012, ZA-2109 Johannesburg, South Africa.
EM dessein@telkomsa.net
RI Dessein, Patrick/AAL-2986-2020
OI , Angela/0000-0003-2555-4125
FU Medical Research Council
FX The study was supported in part by a Medical Research Council grant.
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NR 45
TC 8
Z9 8
U1 0
U2 2
PU CLINICAL & EXPER RHEUMATOLOGY
PI PISA
PA VIA SANTA MARIA 31, 56126 PISA, ITALY
SN 0392-856X
EI 1593-098X
J9 CLIN EXP RHEUMATOL
JI Clin. Exp. Rheumatol.
PD MAR-APR
PY 2010
VL 28
IS 2
BP 230
EP 237
PG 8
WC Rheumatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Rheumatology
GA 604UL
UT WOS:000278303900011
PM 20483045
DA 2025-06-11
ER

PT J
AU Gradinaru, D
   Margina, D
   Borsa, C
   Ionescu, C
   Ilie, M
   Costache, M
   Dinischiotu, A
   Prada, GI
AF Gradinaru, Daniela
   Margina, Denisa
   Borsa, Claudia
   Ionescu, Cristina
   Ilie, Mihaela
   Costache, Marieta
   Dinischiotu, Anca
   Prada, Gabriel-Ioan
TI Adiponectin: possible link between metabolic stress and oxidative stress
   in the elderly
SO AGING CLINICAL AND EXPERIMENTAL RESEARCH
LA English
DT Article
DE Adiponectin; Metabolic syndrome; Oxidative stress; Elderly
ID SERUM URIC-ACID; HOMEOSTASIS MODEL ASSESSMENT; LOW-DENSITY-LIPOPROTEIN;
   GLYCATION END-PRODUCTS; INSULIN-RESISTANCE; ARTERIAL STIFFNESS; OBESITY;
   ASSOCIATION; INFLAMMATION; COMPONENTS
AB Objective The aim of this study was to evaluate the relationships between the serum levels of adiponectin and systemic oxidative stress exerted on lipids, proteins, as well as endothelial function and cardiovascular diseases (CVD) risk markers, in elderly subjects with metabolic syndrome (MS).
   Methods The serum advanced glycation and oxidation protein products, low-density lipoprotein susceptibility to oxidation (oxLDL), nitric oxide metabolic pathway products (NOx), serum lipid peroxidation, as well as total antioxidant/oxidative capacity (TAC/TOC), were analyzed in elderly subjects with MS (n = 44), compared to agedmatched control (n = 39).
   Results We pointed out significantly lower levels of adiponectin in elderly MS subjects concomitantly with significantly higher levels of oxidative stress and CVD risk markers. Significant positive correlations were found between serum adiponectin levels and HDL-cholesterol (p < 0.05) and the total cholesterol/LDL-cholesterol ratio (p < 0.01). Additionally, adiponectin levels were significantly inversely associated with insulin resistance index HOMA-IR, r = -0.348; p < 0.05) and serum lipid peroxidation (r = -0.337; p < 0.05), and significantly positively with the antioxidant capacity (TAC, r = 0.339; p < 0.05). Conversely, adiponectin levels were significantly negatively (r = -0.310; p < 0.05) associated with serum uric acid concentration.
   Conclusions The major protective role of adiponectin versus stress related to an impaired glucose and lipid metabolism suggests that adiponectin plays a critical role in adiposity-related metabolic stress and redox homeostasis.
C1 [Gradinaru, Daniela; Margina, Denisa; Ilie, Mihaela] Carol Davila Univ Med & Pharm, Dept Biochem, Fac Pharm, Sect 2, 6 Taian Vuia St, Bucharest 020956, Romania.
   [Borsa, Claudia; Ionescu, Cristina; Prada, Gabriel-Ioan] Ana Aslan Natl Inst Gerontol & Geriatr, Sect 1, 9 Caldarusani St,POB 2-4, Bucharest 011241, Romania.
   [Costache, Marieta; Dinischiotu, Anca] Univ Bucharest, Dept Biochem & Mol Biol, Fac Biol, Sect 5, 91-95 Splaiul Independentei, Bucharest 050107, Romania.
C3 Carol Davila University of Medicine & Pharmacy; National Institute of
   Gerontology & Geriatrics "Ana Aslan"; University of Bucharest
RP Gradinaru, D (corresponding author), Carol Davila Univ Med & Pharm, Dept Biochem, Fac Pharm, Sect 2, 6 Taian Vuia St, Bucharest 020956, Romania.
EM danielagrdnr@yahoo.com
RI Gradinaru, Daniela/A-4952-2019; Prada, Gabriel/B-8448-2016; ILIE,
   Mihaela/D-2355-2010; Margina, Denisa/J-7312-2013; Costache,
   Marieta/F-2806-2016
OI Prada, Gabriel - Ioan/0000-0002-4762-9581; Margina,
   Denisa/0000-0003-3289-147X; Costache, Marieta/0000-0002-8103-3693
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NR 48
TC 35
Z9 35
U1 0
U2 7
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1594-0667
EI 1720-8319
J9 AGING CLIN EXP RES
JI Aging Clin. Exp. Res.
PD AUG
PY 2017
VL 29
IS 4
BP 621
EP 629
DI 10.1007/s40520-016-0629-z
PG 9
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA FC1OG
UT WOS:000406606300006
PM 27688246
DA 2025-06-11
ER

PT J
AU Padmavati, R
   Kantipudi, SJ
   Balasubramanian, S
   Raghavan, V
AF Padmavati, Ramachandran
   Kantipudi, Suvarna Jyothi
   Balasubramanian, Suhavana
   Raghavan, Vijaya
TI Cardiovascular Diseases and Schizophrenia in India: Evidence, Gaps, and
   Way Forward
SO FRONTIERS IN PSYCHIATRY
LA English
DT Review
DE cardiovascular diseases; risk factors; interventions; India;
   schizophrenia
ID SEVERE MENTAL-ILLNESS; METABOLIC SYNDROME; PHYSICAL HEALTH;
   RISK-FACTORS; BIPOLAR DISORDER; LIFE-STYLE; PREVALENCE; PEOPLE; CARE;
   PREDICTORS
AB Background: The importance of physical health among persons with schizophrenia is well-established. Studies from developed and developing countries indicated a strong association between cardiovascular diseases and schizophrenia, while evidence from India is scattered and in its infancy. Hence, the aims of the study were to collate available studies from India on cardiovascular diseases among persons with schizophrenia, identify knowledge gaps and challenges, and discuss recommendations to improve clinical care and research on cardiovascular diseases among persons with schizophrenia in India. Materials and methods: A comprehensive literature review of Indian studies on cardiovascular diseases and schizophrenia was conducted to collate and synthesise available knowledge. Results: Several risk factors for cardiovascular disease predominated among persons with schizophrenia. Metabolic syndrome and obesity were the key factors that were reported. Knowledge gaps were identified with respect to the prevalence of cardiovascular diseases among persons with schizophrenia. Sparse research in interventions to prevent and reduce the impact of cardiovascular diseases among persons with schizophrenia was noted. Conclusion: Targeted efforts are needed at the clinic, community, and policy levels to understand the impact of cardiovascular diseases among persons with schizophrenia. Robust and feasible interventions targeting cardiovascular diseases and its varied risk factors in persons with schizophrenia, that can be implemented in tertiary mental health services, need to be developed and tested.
C1 [Padmavati, Ramachandran; Balasubramanian, Suhavana; Raghavan, Vijaya] Schizophrenia Res Fdn, Chennai, Tamil Nadu, India.
   [Kantipudi, Suvarna Jyothi] Sri Ramachandra Inst Higher Educ & Res, Dept Psychiat, Chennai, Tamil Nadu, India.
C3 Sri Ramachandra Institute of Higher Education & Research
RP Padmavati, R; Raghavan, V (corresponding author), Schizophrenia Res Fdn, Chennai, Tamil Nadu, India.
EM padmavati@scarfindia.org; vijayaraghavan@scarfindia.org
RI Kantipudi, Suvarna/AAP-4663-2020; Padmavati, Ramachandran/AFP-1809-2022
OI Raghavan, Vijaya/0000-0001-5517-6175
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NR 61
TC 3
Z9 3
U1 2
U2 7
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-0640
J9 FRONT PSYCHIATRY
JI Front. Psychiatry
PD JUN 24
PY 2021
VL 12
AR 639295
DI 10.3389/fpsyt.2021.639295
PG 8
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA TF2TB
UT WOS:000670563400001
PM 34248694
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Turner, MB
   Dalmasso, C
   Loria, AS
AF Turner, Meghan Blair
   Dalmasso, Carolina
   Loria, Analia S.
TI The adipose tissue keeps the score: priming of the adrenal-adipose
   tissue axis by early life stress predisposes women to obesity and
   cardiometabolic risk
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Review
DE adverse childhood experience; sex differences; obesity; aldosterone; HPA
   axis
ID CORTICOTROPIN-RELEASING HORMONE; ADVERSE CHILDHOOD EXPERIENCES;
   POSTNATAL MATERNAL SEPARATION; ANGIOTENSIN-II; SEX-DIFFERENCES;
   DENDRITIC CELLS; CORTICOSTERONE SECRETION; PARAVENTRICULAR NUCLEUS;
   ALDOSTERONE SECRETION; MESSENGER-RNA
AB Adverse Childhood Experiences (ACEs) refer to early life stress events, including abuse, neglect, and other psychosocial childhood traumas that can have long-lasting effects on a wide range of physiological functions. ACEs provoke sex-specific effects, whereas women have been shown to display a strong positive correlation with obesity and cardiometabolic disease. Notably, rodent models of chronic behavioral stress during postnatal life recapitulate several effects of ACEs in a sex-specific fashion. In this review, we will discuss the potential mechanisms uncovered by models of early life stress that may explain the greater susceptibility of females to obesity and metabolic risk compared with their male counterparts. We highlight the early life stress-induced neuroendocrine shaping of the adrenal-adipose tissue axis as a primary event conferring sex-dependent heightened sensitivity to obesity.
C1 [Turner, Meghan Blair; Dalmasso, Carolina; Loria, Analia S.] Univ Kentucky, Dept Pharmacol & Nutr Sci, Lexington, KY 40506 USA.
C3 University of Kentucky
RP Loria, AS (corresponding author), Univ Kentucky, Dept Pharmacol & Nutr Sci, Lexington, KY 40506 USA.
EM analia.loria@uky.edu
RI Dalmasso, Carolina/LKO-3360-2024
FU National Institutes of Health [R01 HL111354]
FX The author(s) declare financial support was received for the research,
   authorship, and/or publication of this article. This study was supported
   by the National Institutes of Health grant R01 HL111354 to ASL.
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NR 131
TC 0
Z9 0
U1 0
U2 1
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD OCT 18
PY 2024
VL 15
AR 1481923
DI 10.3389/fendo.2024.1481923
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA K6X6D
UT WOS:001345290100001
PM 39493777
OA gold
DA 2025-06-11
ER

PT J
AU Innes, KE
   Selfe, TK
   Brown, CJ
   Rose, KM
   Thompson-Heisterman, A
AF Innes, K. E.
   Selfe, T. K.
   Brown, C. J.
   Rose, K. M.
   Thompson-Heisterman, A.
TI The Effects of Meditation on Perceived Stress and Related Indices of
   Psychological Status and Sympathetic Activation in Persons with
   Alzheimer's Disease and Their Caregivers: A Pilot Study
SO EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Article
ID REPORTED SLEEP DISTURBANCES; MIND-BODY THERAPIES; CEREBRAL-BLOOD-FLOW;
   INSULIN-RESISTANCE; CARDIOVASCULAR-DISEASE; COGNITIVE IMPAIRMENT;
   DEMENTIA CAREGIVERS; METABOLIC SYNDROME; MEMORY COMPLAINTS; OLDER-ADULTS
AB Objective. To investigate the effects of an 8-week meditation program on perceived stress, sleep, mood, and related outcomes in adults with cognitive impairment and their caregivers. Methods. Community-dwelling adults with a diagnosis of mild cognitive impairment or early-stage Alzheimer's disease, together with their live-in caregivers, were enrolled in the study. After a brief training, participants were asked to meditate for 11 minutes, twice daily for 8 weeks. Major outcomes included measures of perceived stress (Perceived Stress Scale), sleep (General Sleep Disturbance Scale), mood (Profile of Mood States), memory functioning (Memory Functioning Questionnaire), and blood pressure. Participants were assessed pre- and post-intervention. Results. Ten participants (5 of 6 dyads) completed the study. Treatment effects did not vary by participant status; analyses were thus pooled across participants. Adherence was good (meditation sessions completed/week: X = 11.4 +/- 1.1). Participants demonstrated improvement in all major outcomes, including perceived stress (P < 0.001), mood (overall, P = 0.07; depression, P = 0.01), sleep (P < 0.04), retrospective memory function (P = 0.04), and blood pressure (systolic, P = 0.004; diastolic, P = 0.065). Conclusions. Findings of this exploratory trial suggest that an 8-week meditation program may offer an acceptable and effective intervention for reducing perceived stress and improving certain domains of sleep, mood, and memory in adults with cognitive impairment and their caregivers.
C1 [Innes, K. E.; Selfe, T. K.] W Virginia Univ, Sch Med, Dept Community Med, Morgantown, WV 26506 USA.
   [Innes, K. E.; Selfe, T. K.; Brown, C. J.; Rose, K. M.] Univ Virginia Hlth Syst, Ctr Study Complementary & Alternat Therapies, Charlottesville, VA 22908 USA.
   [Rose, K. M.; Thompson-Heisterman, A.] Univ Virginia Hlth Syst, Dept Family Community & Mental Hlth Syst, Sch Nursing, Charlottesville, VA 22908 USA.
C3 West Virginia University; University of Virginia; University of Virginia
   (UVA) Health System; University of Virginia; University of Virginia
   (UVA) Health System
RP Innes, KE (corresponding author), W Virginia Univ, Sch Med, Dept Community Med, POB 9190, Morgantown, WV 26506 USA.
EM kinnes@hsc.wvu.edu
RI Selfe, Terry/J-8183-2017; Rose, Karen/M-2700-2016
OI Rose, Karen/0000-0001-7382-3671; Selfe, Terry/0000-0002-2181-2011
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NR 80
TC 65
Z9 82
U1 0
U2 39
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1741-427X
EI 1741-4288
J9 EVID-BASED COMPL ALT
JI Evid.-based Complement Altern. Med.
PY 2012
VL 2012
AR 927509
DI 10.1155/2012/927509
PG 9
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Integrative & Complementary Medicine
GA 906WP
UT WOS:000301380100001
PM 22454689
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Häfner, S
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   Reincke, M
   Kuenzel, H
   Holle, R
   Rupprecht, R
   Ladwig, KH
AF Haefner, S.
   Baumert, J.
   Emeny, R. T.
   Lacruz, M. E.
   Bidlingmaier, M.
   Reincke, M.
   Kuenzel, H.
   Holle, R.
   Rupprecht, R.
   Ladwig, K. H.
CA MONICA KORA Study Investigators
TI To live alone and to be depressed, an alarming combination for the
   renin-angiotensin-aldosterone-system (RAAS)
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE Renin angiotensin-system; Living alone; Depressed
ID CONVERTING ENZYME GENE; KORA AUGSBURG COHORT; METABOLIC SYNDROME;
   MYOCARDIAL-INFARCTION; DIABETES-MELLITUS; PHYSICAL-ACTIVITY;
   SOCIAL-ISOLATION; STRESS; PITUITARY; MOOD
AB Introduction: The renin angiotensin aldosterone-system (RAAS) is one of the most important systems involved in the pathogenesis of cardiovascular diseases. Its role in stress response has been generally neglected, although the progression of cardiovascular disease is considerably increased in the presence of stress and especially in the presence of depression risk.
   With the present analysis we aimed to evaluate whether the activity of the RAAS correlates with depressive symptomatology and with chronic stress. Moreover, we aimed to analyse whether stress response is altered in the presence of depressed symptomatology. We chose "living alone" to be our paradigm of chronic stress.
   Methods and results: Aldosterone and renin levels were assessed in 1743 (829 men, 914 women) from the population-based KORA study (Cooperative Health Research in the Region of Augsburg). The relationship between aldosterone, renin levels and the different combinations of living alone and depressive symptomatology was examined in three different multiple linear regression models adjusted for age, sex, creatinine levels, potassium levels, body mass index (BMI) and bio-behavioural factors.
   Neither "living alone" nor depressive symptomatology alone were associated with an activation of the RAAS, but the combination of living alone and depressive symptomatology yielded a highly significant increase in the aldosterone (p < 0.01) and renin level (p = 0.03).
   Conclusion: Our findings show that depressive symptomatology is associated with a hyper-responsiveness to chronic stress. Under the condition of chronic stress depressed individuals have an activated RAAS. Activation of the RAAS might explain the known increased risk of negative cardiovascular disease outcomes in this group. (C) 2011 Elsevier Ltd. All rights reserved.
C1 [Haefner, S.; Baumert, J.; Emeny, R. T.; Lacruz, M. E.; Ladwig, K. H.] German Res Ctr Environm Hlth, Helmholtz Zentrum Muenchen, Inst Epidemiol, D-85764 Neuherberg, Germany.
   [Bidlingmaier, M.; Reincke, M.; Kuenzel, H.] Univ Munich, Dept Internal Med, Munich, Germany.
   [Haefner, S.; Rupprecht, R.] Univ Munich, Dept Psychiat & Psychotherapy, Munich, Germany.
   [Holle, R.] German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Inst Hlth Econ & Hlth Care Management, D-85764 Neuherberg, Germany.
   [Ladwig, K. H.] Tech Univ Munich, Univ Hosp, Dept Psychosomat Med & Psychotherapy, Munich, Germany.
C3 Helmholtz Association; Helmholtz-Center Munich - German Research Center
   for Environmental Health; University of Munich; University of Munich;
   Helmholtz Association; Helmholtz-Center Munich - German Research Center
   for Environmental Health; Technical University of Munich; University of
   Munich
RP Ladwig, KH (corresponding author), German Res Ctr Environm Hlth, Helmholtz Zentrum Muenchen, Inst Epidemiol, Ingolstaedter Landstr 1, D-85764 Neuherberg, Germany.
EM ladwig@helmholtz-muenchen.de
RI Emeny, Rebecca/I-1100-2014; Lacruz, Maria/KHV-7908-2024; Holle,
   Rolf/D-9333-2013; Ladwig, Karl-Heinz/B-5351-2014
OI Lacruz, Maria Elena/0000-0003-2036-3039
FU Helmholtz Zentrum Munchen, German Research Center for Environmental
   Health; German Federal Ministry of Education, Science, Research and
   Technology; State of Bavaria
FX The KORA research platform and the KORA Augsburg studies are financed by
   the Helmholtz Zentrum Munchen, German Research Center for Environmental
   Health, which is funded by the German Federal Ministry of Education,
   Science, Research and Technology and by the State of Bavaria.
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NR 64
TC 37
Z9 40
U1 1
U2 6
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
EI 1873-3360
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD FEB
PY 2012
VL 37
IS 2
BP 230
EP 237
DI 10.1016/j.psyneuen.2011.06.007
PG 8
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA 888BW
UT WOS:000299979800007
PM 21742440
DA 2025-06-11
ER

PT J
AU Lammers-van der Holst, HM
   Kerkhof, GA
AF Lammers-van der Holst, Heidi M.
   Kerkhof, Gerard A.
TI Shift work tolerance and the importance of sleep quality: a study of
   police officers
SO BIOLOGICAL RHYTHM RESEARCH
LA English
DT Article
DE inter-individual variability; sleep; police; shift work tolerance
ID CARDIOVASCULAR-DISEASE; INDIVIDUAL-DIFFERENCES; METABOLIC SYNDROME;
   RECOVERY; DURATION; DISORDER; FATIGUE; STRESS; HEALTH
AB The aim of this study was to examine how subjective shift work tolerance was related to general health variables, with the expectation of inter-individual differences in the nature of this relation. A total of 740 employees of the Dutch Police force completed a questionnaire, covering seven health-related domains: sleep quality, sleep duration, need for recovery, fatigue, physical health, mental health, and work-life balance. Based on subjective reports of shift work tolerance, participants were classified as intolerant, medium-tolerant, or tolerant workers. Analysis involved group comparisons, regression, and cluster analysis. Eighteen percentage of the shift workers were classified as intolerant. The intolerant and medium-tolerant workers expressed more severe complaints than the tolerant workers, for all seven health-related domains. Shift work tolerance was primarily related to sleep quality and subsequently to need for recovery, fatigue, and work-life balance. No indications were found for systematic inter-individual differences in the nature of this relationship. For all participants equally, the degree of shift work tolerance was related to the severity of health-related complaints. This study highlights the central role of sleep for tolerance to shift work and underlines the need for occupational medicine to take explicit account of sleep.
C1 [Lammers-van der Holst, Heidi M.; Kerkhof, Gerard A.] Univ Amsterdam, Dept Psychol, NL-1018 XA Amsterdam, Netherlands.
   [Kerkhof, Gerard A.] MCH Westeinde Hosp, Ctr Sleep Wake Disorders, The Hague, Netherlands.
C3 University of Amsterdam
RP Lammers-van der Holst, HM (corresponding author), Univ Amsterdam, Dept Psychol, Weesperpl 4, NL-1018 XA Amsterdam, Netherlands.
EM H.M.Lammers-vanderHolst@uva.nl
FU ZonMw [401000010]
FX The research for this manuscript was carried out within the framework of
   the University of Amsterdam, supported by ZonMw, under Grant 401000010,
   awarded to Prof. G.A. Kerkhof. We wish to express our appreciation to
   the Dutch Police force for their willingness to participate in this
   study.
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NR 34
TC 14
Z9 23
U1 1
U2 49
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0929-1016
EI 1744-4179
J9 BIOL RHYTHM RES
JI Biol. Rhythm Res.
PD MAR 4
PY 2015
VL 46
IS 2
BP 257
EP 264
DI 10.1080/09291016.2014.985002
PG 8
WC Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Life Sciences & Biomedicine - Other Topics; Physiology
GA CB0DT
UT WOS:000349296300001
DA 2025-06-11
ER

PT J
AU Akil, MA
   Oylumlu, M
   Demir, M
   Ozbek, M
   Polat, N
   Acet, H
   Bilik, MZ
AF Akil, M. A.
   Oylumlu, M.
   Demir, M.
   Ozbek, M.
   Polat, N.
   Acet, H.
   Bilik, M. Z.
TI Predictive value of lymphocyte to monocyte ratio for cardiac syndrome X
SO EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
LA English
DT Article
DE Lymphocyte to monocyte ratio; Cardiac syndrome X; Inflammation markers
ID CORONARY-ARTERY-DISEASE; MEAN PLATELET VOLUME; CHEST-PAIN;
   ANGINA-PECTORIS; INFLAMMATION; ASSOCIATION; SEVERITY
AB OBJECTIVE: Cardiac syndrome X (CSX) is typically described with ischemia in stress tests in addition to angina-like chest pain and without stenosis in coronary angiography. We aimed at determining the relationship between LMR and CSX.
   PATIENTS AND METHODS: We retrospectively collected patients with CSX between January 2016 and December 2019. Patients with typical angina-like chest pain, normal 12-lead electro-cardiography at rest, a positive response to the exercise test (> 0.1 mV ST-segment depression at 80 ms after the J point in two or more contiguous leads) or ischemia on myocardial perfusion scintigraphy and normal coronary angiography were included in the study as CSX patients.
   RESULTS: This study consisted of 116 patients with CSX and 153 control groups. The mean age of the patients with CSX was 52.7 +/- 9.7 years, and the mean age of the control group was 53.7 +/- 10.6 years (p= 0.416). The patients with CSX were more likely to have higher monocyte counts and LMR. According to the Pearson correlation test, the CRP value negatively correlated with the LMR. In multivariate logistic regression analysis, LMR remained a significant predictor of CSX. In ROC analysis, LMR <4.1 had 64% sensitivity and 50% specificity (ROC area under curve: 0.587, 95% CI: 0.519-0.655, p=0.015) in accurately predicting a CSX diagnosis.
   CONCLUSIONS: We showed that lower LMR levels were associated with the presence of CSX.
C1 [Akil, M. A.; Oylumlu, M.; Demir, M.; Ozbek, M.; Polat, N.; Acet, H.; Bilik, M. Z.] Dicle Univ, Fac Med, Dept Cardiol, Diyarbakir, Turkey.
C3 Dicle University
RP Bilik, MZ (corresponding author), Dicle Univ, Fac Med, Dept Cardiol, Diyarbakir, Turkey.
EM drmzbilik@gmail.com
RI Demir, Muhammed/ABC-7282-2021; akil, mehmet/B-2876-2014; Özbek,
   mehmet/ADV-6760-2022
OI ozbek, mehmet/0000-0003-2243-6190
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NR 34
TC 1
Z9 2
U1 0
U2 4
PU VERDUCI PUBLISHER
PI ROME
PA VIA GREGORIO VII, ROME, 186-00165, ITALY
SN 1128-3602
J9 EUR REV MED PHARMACO
JI Eur. Rev. Med. Pharmacol. Sci.
PY 2022
VL 26
IS 12
BP 4303
EP 4308
PG 6
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 2S3ED
UT WOS:000821677800020
PM 35776031
DA 2025-06-11
ER

PT J
AU Trudel-Fitzgerald, C
   Qureshi, F
   Appleton, AA
   Kubzansky, LD
AF Trudel-Fitzgerald, Claudia
   Qureshi, Farah
   Appleton, Allison A.
   Kubzansky, Laura D.
TI A healthy mix of emotions: underlying biological pathways linking
   emotions to physical health
SO CURRENT OPINION IN BEHAVIORAL SCIENCES
LA English
DT Review
ID CARDIOVASCULAR-DISEASE RISK; REACTIVE PROTEIN-LEVELS;
   CORONARY-HEART-DISEASE; INFLAMMATORY CYTOKINES; DIVERGENT ASSOCIATIONS;
   DEVELOPMENTAL ORIGINS; REGULATION STRATEGIES; CARDIOMETABOLIC RISK;
   SOCIOECONOMIC-STATUS; PSYCHOSOCIAL FACTORS
AB Both positive (e.g., happiness) and negative (e.g., anxiety) emotions have been distinctively associated with health and disease outcomes. However, whether emotion-related effects are driven by specific emotions or by shared underlying features of similar co-occurring (or mixes of) emotions is still debated. This narrative review summarizes recent scientific advances regarding whether mixed emotions and emotion regulation abilities influence physical health over the lifecourse. While behavioral and biological pathways are commonly proposed to explain these relationships, biological pathways are less well understood. As a result, here we specifically focus on known and novel biological pathways. Future directions for empirical and clinical research aimed at identifying ways to lower the risk of and burden related to chronic diseases are also discussed.
C1 [Trudel-Fitzgerald, Claudia; Qureshi, Farah; Kubzansky, Laura D.] Harvard TH Chan Sch Publ Hlth, Dept Social & Behav Sci, Boston, MA 02115 USA.
   [Appleton, Allison A.] SUNY Albany, Dept Epidemiol & Biostat, Sch Publ Hlth, Rensselaer, NY USA.
C3 Harvard University; Harvard T.H. Chan School of Public Health; State
   University of New York (SUNY) System; University at Albany, SUNY
RP Trudel-Fitzgerald, C (corresponding author), Harvard TH Chan Sch Publ Hlth, Dept Social & Behav Sci, Boston, MA 02115 USA.
EM ctrudel@hsph.harvard.edu
OI Trudel-Fitzgerald, Claudia/0000-0001-9989-4259; Qureshi,
   Farah/0000-0002-9092-8085
FU Canadian Institute of Health Research; Fonds de Recherche du Que
   'bec-Sante' [postdoctoral fellowships award]; JPB Foundation [JPB
   Environmental Health Fellowship award]
FX This work was supported by the Canadian Institute of Health Research and
   the Fonds de Recherche du Que 'bec-Sante' [postdoctoral fellowships
   awarded to Dr Claudia Trudel-Fitzgerald, 2014-2018] and by The JPB
   Foundation [JPB Environmental Health Fellowship awarded to Dr Allison
   Appleton and managed by the Harvard T.H. Chan School of Public Health,
   2014-2018].
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NR 56
TC 28
Z9 34
U1 1
U2 19
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 2352-1546
EI 2352-1554
J9 CURR OPIN BEHAV SCI
JI Curr. Opin. Behav. Sci.
PD JUN
PY 2017
VL 15
BP 16
EP 21
DI 10.1016/j.cobeha.2017.05.003
PG 6
WC Behavioral Sciences; Neurosciences; Psychology, Experimental
WE Social Science Citation Index (SSCI)
SC Behavioral Sciences; Neurosciences & Neurology; Psychology
GA FL8AV
UT WOS:000414472900005
DA 2025-06-11
ER

PT J
AU Di Majo, D
   Sardo, P
   Giglia, G
   Di Liberto, V
   Zummo, FP
   Zizzo, MG
   Caldara, GF
   Rappa, F
   Intili, G
   van Dijk, RM
   Gallo, D
   Ferraro, G
   Gambino, G
AF Di Majo, Danila
   Sardo, Pierangelo
   Giglia, Giuseppe
   Di Liberto, Valentina
   Zummo, Francesco Paolo
   Zizzo, Maria Grazia
   Caldara, Gaetano Felice
   Rappa, Francesca
   Intili, Giorgia
   van Dijk, Roelof Maarten
   Gallo, Daniele
   Ferraro, Giuseppe
   Gambino, Giuditta
TI Correlation of Metabolic Syndrome with Redox Homeostasis Biomarkers:
   Evidence from High-Fat Diet Model in Wistar Rats
SO ANTIOXIDANTS
LA English
DT Article
DE oxidative stress; anti-oxidant barriers; glucose tolerance; lipid
   metabolism; non-alcoholic fatty liver disease; adipose tissue
   distribution
ID OXIDATIVE STRESS LEVELS; INSULIN-RESISTANCE; LIVER; ASSOCIATION;
   CAPACITY; RODENT; LEPTIN; PLASMA; EYE
AB Metabolic Syndrome (MetS) is an extremely complex disease. A non-balanced diet such as high-fat diet (HFD) induces metabolic dysfunction that could modify redox homeostasis. We here aimed at exploring redox homeostasis in male Wistar rats, following 8 weeks of HFD, correlating the eventual modification of selected biomarkers that could be associated with the clinical manifestations of MetS. Therefore, we selected parameters relative to both the glucose tolerance and lipid altered metabolism, but also oxidative pattern. We assessed some biomarkers of oxidative stress i.e., thiols balance, lipid peroxidation and antioxidant barriers, via the use of specific biochemical assays, individuating eventual cross correlation with parameters relative to MetS through a Principal Component Analysis (PCA). The present study shows that 8 weeks of HFD induce MetS in rats, altering glucose and lipid homeostasis and increasing visceral adipose tissue, but also impairing the physiological antioxidant responses that could not counteract the oxidative stress condition. Crucially, cross-correlation analysis suggested that the assessment of specific oxidative stress parameters reported here can provide information comparable to the more widely acquired biomarkers of Mets such as glucose tolerance. Lastly, hepatic steatosis in association with the oxidative stress condition was also highlighted by histological analysis. This research will elucidate the fundamental impact of these oxidative stress parameters on MetS induced in the HFD rat model, tracing paths for developing prevention approaches.
C1 [Di Majo, Danila; Sardo, Pierangelo; Giglia, Giuseppe; Di Liberto, Valentina; Zummo, Francesco Paolo; Rappa, Francesca; Intili, Giorgia; Gallo, Daniele; Ferraro, Giuseppe; Gambino, Giuditta] Univ Palermo, Dept Biomed Neurosci & Adv Diagnost BIND, I-90127 Palermo, Italy.
   [Di Majo, Danila; Sardo, Pierangelo; Ferraro, Giuseppe] Univ Palermo, Postgrad Sch Nutr & Food Sci, I-90100 Palermo, Italy.
   [Giglia, Giuseppe] IEMEST, Euro Mediterranean Inst Sci & Technol, I-90139 Palermo, Italy.
   [Zizzo, Maria Grazia] Univ Palermo, Dept Biol Chem & Pharmaceut Sci & Technol STEBICEF, Viale Sci, I-90128 Palermo, Italy.
   [Zizzo, Maria Grazia] ATeN Adv Technol Network Ctr, Viale Sci, I-90128 Palermo, Italy.
   [Caldara, Gaetano Felice] Univ Palermo, I-90100 Palermo, Italy.
   [van Dijk, Roelof Maarten] Staburo GmbH, D-81549 Munich, Germany.
C3 University of Palermo; University of Palermo; University of Palermo;
   University of Palermo
RP Gambino, G (corresponding author), Univ Palermo, Dept Biomed Neurosci & Adv Diagnost BIND, I-90127 Palermo, Italy.
EM giuditta.gambino@unipa.it
RI Francesca, Rappa/ADW-8431-2022; Zummo, Francesco Paolo/HME-2405-2023; Di
   Majo, Danila/A-9078-2015; Di+Liberto, Valentina/ACL-0264-2022; Giglia,
   Giuseppe/M-7100-2016
OI Zummo, Francesco Paolo/0000-0001-9872-8574; zizzo, maria
   grazia/0000-0003-1996-6529; Giglia, Giuseppe/0000-0001-5616-3595; DI
   MAJO, Danila/0000-0002-0533-6932; Caldara, Gaetano/0000-0001-6604-9040;
   Di Liberto, Valentina/0000-0002-8574-0061; rappa,
   francesca/0000-0001-6610-5268; Gambino, Giuditta/0000-0001-8155-2808
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NR 69
TC 13
Z9 14
U1 0
U2 4
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD JAN
PY 2023
VL 12
IS 1
AR 89
DI 10.3390/antiox12010089
PG 18
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA 7X8JD
UT WOS:000914440700001
PM 36670955
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Torun, E
   Gökçe, S
   Ozgen, IT
   Aydin, S
   Cesur, Y
AF Torun, Emel
   Gokce, Selim
   Ozgen, Ilker Tolga
   Aydin, Sinem
   Cesur, Yasar
TI Serum paraoxonase activity and oxidative stress and their relationship
   with obesity-related metabolic syndrome and non-alcoholic fatty liver
   disease in obese children and adolescents
SO JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
LA English
DT Article
DE hepatosteatosis; paraoxonase; total antioxidant stress; total oxidant
   stress
ID INSULIN-RESISTANCE; GENE POLYMORPHISMS; ANTIOXIDANT STATUS;
   LIPOPROTEINS; PARAMETERS; THERAPY; HEALTHY; GLUCOSE
AB Objective: Oxidative stress has been reported to be involved in the pathogenesis of metabolic disorders related with obesity. The aim of the study was to investigate the association of oxidative stress and paraoxonase activities with non-alcoholic fatty liver disease (NAFLD) as well as metabolic syndrome.
   Materials and methods: A total of 109 obese children and adolescents and 44 healthy and lean control subjects were enrolled in the study. According to their ultrasonographic steatosis scores, they were classified into four groups as follows: healthy children; obese, non-NAFLD; obese, grade I-NAFLD; and obese, grade II III NAFLD. The biochemical parameters and insulin resistance (HOMA-IR) were evaluated from fasting samples. The plasma total antioxidant status (TAS), total oxidant status (TOS), and serum paraoxonase activities were measured and then oxidative stress index (OSI) was calculated as the indicator of degree of oxidative stress.
   Results: As the steatosis increased, the alanine aminotransferase, C-reactive protein, HOMA-IR, total cholesterol, and LDL cholesterol increased, whereas HDL cholesterol decreased. The TAS measurements were higher in the obese NAFLD group compared with that of the healthy control group. The TOS and OSI measurements did not differ between the groups. Paraoxonase activities increased significantly as steatosis increased.
   Conclusions: Among the children in this study, no relationship could be demonstrated between obesity with/without steatosis and oxidant/antioxidant status.
C1 [Torun, Emel] Bezmialem Vakif Univ Hosp, Dept Pediat, Istanbul, Turkey.
   [Gokce, Selim] Bezmialem Vakif Univ, Fac Med, Dept Pediat Gastroenterol, Istanbul, Turkey.
   [Ozgen, Ilker Tolga; Cesur, Yasar] Bezmialem Vakif Univ, Fac Med, Dept Pediat Endocrinol & Metab, Istanbul, Turkey.
   [Aydin, Sinem] Bezmialem Vakif Univ, Fac Med, Dept Radiol, Istanbul, Turkey.
C3 Bezmialem Vakif University; Bezmialem Vakif University; Bezmialem Vakif
   University; Bezmialem Vakif University
RP Torun, E (corresponding author), Bezmialem Vakif Univ Hosp, Dept Pediat, Adnan Menderes Ave,PK 3409 Fatih, Istanbul, Turkey.
RI torun, emel/NKP-0985-2025; aydin, sinem/ABI-4185-2020; Ozgen,
   Ilker/LKK-2184-2024
OI Ozgen, Ilker Tolga/0000-0001-6592-9652
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NR 36
TC 14
Z9 18
U1 0
U2 7
PU WALTER DE GRUYTER GMBH
PI BERLIN
PA GENTHINER STRASSE 13, D-10785 BERLIN, GERMANY
SN 0334-018X
EI 2191-0251
J9 J PEDIATR ENDOCR MET
JI J. Pediatr. Endocrinol. Metab.
PD JUL
PY 2014
VL 27
IS 7-8
BP 667
EP 675
DI 10.1515/jpem-2013-0337
PG 9
WC Endocrinology & Metabolism; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Pediatrics
GA AL0TK
UT WOS:000338839500015
PM 24706428
DA 2025-06-11
ER

PT J
AU Liptak, R
   Gromova, B
   Gardlik, R
AF Liptak, Robert
   Gromova, Barbora
   Gardlik, Roman
TI Fecal Microbiota Transplantation as a Tool for Therapeutic Modulation of
   Non-gastrointestinal Disorders
SO FRONTIERS IN MEDICINE
LA English
DT Review
DE intestinal microbiota; metabolic syndrome; liver disease; cardiovascular
   health; autism spectrum disorder; depression; Parkinson's disease;
   enteric nervous system
ID HUMAN GUT MICROBIOME; HEPATIC-ENCEPHALOPATHY; INTESTINAL MICROBIOTA;
   INSULIN SENSITIVITY; METABOLIC SYNDROME; DONOR FECES; BRAIN;
   PHOSPHATIDYLCHOLINE; RIFAXIMIN; OBESITY
AB Fecal microbiota transplantation has been primarily investigated as a therapeutic tool for a number of gut disorders. Optimistic results from clinical studies on Clostridium difficile infection, inflammatory bowel disease and irritable bowel syndrome have stimulated the expansion of possible indications in which FMT might represent a game changing approach. Microbial dysbiosis was shown in a number of non-gastrointestinal disorders. Moreover, FMT was proven to be effective in therapy of numerous animal models of disease. However, only a proportion of these disorders have been addressed in clinical studies using FMT. These include obesity, non-alcoholic fatty liver disease, cardiovascular inflammation and neurological disorders such as autism, depression and Parkinson's disease. Results from preclinical and clinical studies also outlined possible molecular mechanisms that contribute to alleviation of the disease. These range from increasing the circulating levels of microbial metabolites (trimethylamine N-oxide, lipopolysaccharide, short chain fatty acids) to stimulation of the enteric nervous system. Several methodological shortcomings are still to be addressed; however, positive results of the clinical studies indicate that further investigation of FMT as a therapeutic tool for non-gastrointestinal disorders can be expected in upcoming years.
C1 [Liptak, Robert] Comenius Univ, Fac Med, Inst Physiol, Bratislava, Slovakia.
   [Liptak, Robert] Univ Hosp Bratislava, Emergency Dept, Bratislava, Slovakia.
   [Gromova, Barbora; Gardlik, Roman] Comenius Univ, Fac Med, Inst Mol Biomed, Bratislava, Slovakia.
C3 Slovak Academy of Sciences; Comenius University Bratislava; Slovak
   Medical University Bratislava; Comenius University Bratislava
RP Gardlik, R (corresponding author), Comenius Univ, Fac Med, Inst Mol Biomed, Bratislava, Slovakia.
EM romangardlik@gmail.com
RI Gromova, Barbora/GRF-0048-2022; Gardlik, Roman/I-3510-2014
OI Liptak, Robert/0000-0002-0527-0814; Gardlik, Roman/0000-0001-8211-907X;
   Gromova, Barbora/0000-0001-9613-0237
FU Slovak Research and Development Agency [APVV-17-0505]; Ministry of
   Education, Science, Research and Sport of the Slovak Republic; VEGA
   [1/0649/21]
FX Funding This research was funded by the Slovak Research and Development
   Agency under the contract no. APVV-17-0505 and by the Ministry of
   Education, Science, Research and Sport of the Slovak Republic under the
   contract no. VEGA 1/0649/21.
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NR 79
TC 17
Z9 17
U1 1
U2 22
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 2296-858X
J9 FRONT MED-LAUSANNE
JI Front. Med.
PD SEP 7
PY 2021
VL 8
AR 665520
DI 10.3389/fmed.2021.665520
PG 9
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA US3AQ
UT WOS:000697306700001
PM 34557498
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Polland, A
   Davis, M
   Zeymo, A
   Venkatesan, K
AF Polland, Allison
   Davis, Meghan
   Zeymo, Alexander
   Venkatesan, Krishnan
TI Comparison of Correlated Comorbidities in Male and Female Sexual
   Dysfunction: Findings From the Third National Survey of Sexual Attitudes
   and Lifestyles (Natsal-3)
SO JOURNAL OF SEXUAL MEDICINE
LA English
DT Article
DE Female Sexual Dysfunction; Erectile Dysfunction; Comorbidities; Natsal
ID ERECTILE DYSFUNCTION; CARDIOMETABOLIC RISK; BRITAIN FINDINGS;
   UNITED-STATES; PREVALENCE; WOMEN; MEN; HYPERTENSION; ASSOCIATION;
   CONSENSUS
AB Background: Many of the same mechanisms involved in the sexual arousal-response system in men exist in women and can be affected by underlying general medical conditions.
   Aim: To assess whether sexual function in men and women is correlated with similar comorbidities.
   Methods: This study was a secondary analysis of the 3rd National Survey of Sexual Attitudes and Lifestyles (Natsal-3), a prospective stratified probability sample of British individuals 16 to 74 years old interviewed from 2010 to 2012. We assessed for an association between sexual function and the following comorbidities: heart attack, heart disease, hypertension, stroke, diabetes, chronic lung disease, depression, other mental health conditions, other neurologic conditions, obesity, menopause, incontinence, smoking status, and age.
   Outcome: An association was found between multiple medical comorbidities and sexual dysfunction in women and in men.
   Results: 6,711 women and 4,872 men responded to the survey, were in a relationship, and reported sexual activity in the past year. The average age of the women was 35.4 +/- 14.1 and that of the men was 36.8 +/- 15.6. There was an association between sexual function and all variables assessed except for chronic lung disease, heart attack, and incontinence in women compared with stroke, other neurologic conditions, incontinence, and smoking status in men. Comorbidities associated with erectile dysfunction included depression, diabetes, and other heart disease, whereas comorbidities associated with difficulty with lubrication included depression and other heart disease. Menopause was predictive of sexual dysfunction. Male sexual function appeared to decline after 45.5 years of age.
   Clinical Implications: Physicians should be aware of the correlation between medical comorbidities and sexual dysfunction in women and men and should ask patients about specific symptoms that might be associated with underlying medical conditions.
   Strengths and Limitations: Use of a stratified probability sample compared with a convenience sample results in capturing of associations representative of the population. Inclusion of multiple comorbidities in the multivariate analysis allows us to understand the effects of several variables on sexual function. Although this study shows only an association, further research could determine whether there is a causal relation between comorbidities and sexual dysfunction in women.
   Conclusion: Multiple medical comorbidities are associated with sexual dysfunction not only in men but also in women. Copyright (C) 2018, International Society for Sexual Medicine. Published by Elsevier Inc. All rights reserved.
C1 [Polland, Allison; Venkatesan, Krishnan] MedStar Washington Hosp Ctr, Washington, DC USA.
   [Polland, Allison; Davis, Meghan] Georgetown Univ, Washington, DC USA.
   [Zeymo, Alexander] MedStar Hlth Res Inst, Washington, DC USA.
C3 MedStar Washington Hospital Center; Georgetown University; MedStar
   Health Research Institute
RP Polland, A (corresponding author), 106 Irving St NW,POB 405 S, Washington, DC 20010 USA.
EM Allison.R.Polland@medstar.net
OI Davis, Meghan/0000-0001-6632-3716
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NR 31
TC 25
Z9 29
U1 0
U2 8
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1743-6095
EI 1743-6109
J9 J SEX MED
JI J. Sex. Med.
PD MAY
PY 2018
VL 15
IS 5
BP 678
EP 686
DI 10.1016/j.jsxm.2018.02.023
PG 9
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA GH4YV
UT WOS:000433422600010
PM 29631956
DA 2025-06-11
ER

PT J
AU Carlos, S
   De La Fuente-Arrillaga, C
   Bes-Rastrollo, M
   Razquin, C
   Rico-Campà, A
   Martínez-González, MA
   Ruiz-Canela, M
AF Carlos, Silvia
   De La Fuente-Arrillaga, Carmen
   Bes-Rastrollo, Maira
   Razquin, Cristina
   Rico-Campa, Anais
   Martinez-Gonzalez, Miguel Angel
   Ruiz-Canela, Miguel
TI Mediterranean Diet and Health Outcomes in the SUN Cohort
SO NUTRIENTS
LA English
DT Article
DE Mediterranean Diet; adherence; chronic disease; cardiovascular;
   diabetes; weight; metabolic; depression; cognitive decline;
   nephrolithiasis
ID FOOD-FREQUENCY QUESTIONNAIRE; SELF-REPORTED DIAGNOSIS; TERM WEIGHT
   CHANGE; SEGUIMIENTO-UNIVERSIDAD; METABOLIC SYNDROME; FOLLOW-UP;
   CARDIOVASCULAR-DISEASE; PHYSICAL-ACTIVITY; NUT CONSUMPTION; COGNITIVE
   FUNCTION
AB The Mediterranean Dietary (MedDiet) Pattern has been linked to many beneficial health effects. This review summarizes the main findings of a prospective cohort study, the Seguimiento Universidad de Navarra (SUN) cohort, specifically focused on MedDiet and the risk of major chronic disease. It is an open cohort in which 22,786 Spanish university graduates have participated since 1999 until February 2018. Data on diet, lifestyle and clinical diagnosis are collected at baseline and every two years. After reviewing 21 publications from the SUN cohort on the effects of the MedDiet, we conclude that this cohort has provided good evidence that a high MedDiet adherence is associated with a reduced incidence of all-cause mortality, fatal and non-fatal major cardiovascular disease (CVD), type 2 diabetes, weight gain, metabolic syndrome, depression, cognitive decline, and nephrolithiasis. An inverse dose-response relationship was found for many of these associations. The MedDiet was also associated with lower average heart rate, a mitigation of the harmful effects of overweight/obesity on the risk of CVD, and an attenuation of the effects of obesity on type 2 diabetes. A suggestion that the MedDiet may enhance fertility was also found.
C1 [Carlos, Silvia; De La Fuente-Arrillaga, Carmen; Bes-Rastrollo, Maira; Razquin, Cristina; Rico-Campa, Anais; Martinez-Gonzalez, Miguel Angel; Ruiz-Canela, Miguel] Univ Navarra, Dept Prevent Med & Publ Hlth, Pamplona 31008, Spain.
   [Carlos, Silvia; De La Fuente-Arrillaga, Carmen; Bes-Rastrollo, Maira; Razquin, Cristina; Rico-Campa, Anais; Martinez-Gonzalez, Miguel Angel; Ruiz-Canela, Miguel] Navarra Inst Hlth Res, IdiSNA, Navarra 31008, Spain.
   [De La Fuente-Arrillaga, Carmen; Bes-Rastrollo, Maira; Razquin, Cristina; Rico-Campa, Anais; Martinez-Gonzalez, Miguel Angel; Ruiz-Canela, Miguel] Ctr Invest Biomed Red Area Fisiopatol Obesidad &, Madrid 28029, Spain.
C3 University of Navarra; CIBER - Centro de Investigacion Biomedica en Red;
   CIBEROBN
RP Carlos, S; De La Fuente-Arrillaga, C (corresponding author), Univ Navarra, Dept Prevent Med & Publ Hlth, Pamplona 31008, Spain.; Carlos, S; De La Fuente-Arrillaga, C (corresponding author), Navarra Inst Hlth Res, IdiSNA, Navarra 31008, Spain.; De La Fuente-Arrillaga, C (corresponding author), Ctr Invest Biomed Red Area Fisiopatol Obesidad &, Madrid 28029, Spain.
EM scarlos@unay.es; cfuente@unay.es; mbes@unay.es; crazquin@unay.es;
   aricoc@unay.es; mamartinez@unay.es; mcanela@unay.es
RI Martinez-Gonzalez, Miguel/AAE-7669-2019; Ruiz-Canela,
   Miguel/JYP-1794-2024; CARLOS, SILVIA/L-9123-2014; BES-RASTROLLO,
   MAIRA/A-1329-2009; Razquin, Cristina/H-2366-2017; Ruiz-Canela,
   Miguel/I-7738-2016
OI CARLOS, SILVIA/0000-0002-4968-7080; BES-RASTROLLO,
   MAIRA/0000-0002-9139-4206; Razquin, Cristina/0000-0003-3480-2645;
   Ruiz-Canela, Miguel/0000-0002-7684-2787
FU Spanish Government-Instituto de Salud Carlos III; European Fund for
   Regional and Economic Development (FEDER) [RD 06/0045]; CIBER-OBN
   [PI10/02658, PI10/02293, PI13/00615, PI14/01668,, PI14/01798,
   PI14/01764, FIS17/01795, G03/140]; Navarra Regional Government [45/2011,
   122/2014]; University of Navarra; European Research Council [340918]
FX We are grateful to all the institutions that have supported the project
   with their funding: the Spanish Government-Instituto de Salud Carlos
   III, and the European Fund for Regional and Economic Development (FEDER;
   RD 06/0045), CIBER-OBN, grants PI10/02658, PI10/02293, PI13/00615,
   PI14/01668, PI14/01798, PI14/01764, FIS17/01795 and G03/140), the
   Navarra Regional Government (45/2011, 122/2014), and the University of
   Navarra. The funding by the European Research Council [Advanced Research
   Grant 2014-2019; agreement #340918 granted to MAM-G fo the PREDIMEDPLUS
   is also acknowledged. We thank other members of the SUN Group: Alonso
   A., Alvarez I., Balaguer A., Barbagallo M., Barrientos I., Barrio-Lopez
   M.T., Basterra-Gortari F.J., Battezzati A., Bazal P., Benito S., Bertoli
   S., Beulen Y., Beunza J.J., Buil-Cosiales P., Canales M., Carmona L.,
   Cervantes S., Cristobo C., de Irala J., de la Rosa P. A.,
   Delgado-Rodriguez M., Diaz-Gutierrez J., Diez Espino J., Dominguez L.,
   Donat-Vargas C., Donazar M., Eguaras S., Fernandez-Montero A., Fresan
   U., Galbete C., Garcia-Arellano A., Garcia Lopez M., Gardeazabal I., Gea
   A., Gutierrez-Bedmar M., Gomez-Domingos A. L., Gomez-Donoso C.,
   Gomez-Gracia E., Goni E., Goni L., Guillen F., Henriquez P., Hernandez
   A., Hidalgo-Santamaria M., Hu E., Lahortiga F., Leone A., Llorca J.,
   Lopez del Burgo C., Mari A., Marques I., Marti A., Martin Calvo N.,
   Martin-Moreno J. M., Martinez J. A., Martinez-Lapiscina E.H., Mendonca
   R., Menendez C., Molendijk M., Molero P., Murphy K., Munoz M.,
   Nunez-Cordoba J.M., Pajares R., Papadaki A., Parletta N., Perez de
   Ciriza P., Perez Cornago A., Perez de Rojas J., Pimenta A. M., Pons J.,
   Ramallal R., Romanos A., Ruano C., Ruiz L., Ruiz Zambrana A., Salgado
   E., San Julian B., Sanchez D., Sanchez-Bayona R., Sanchez-Tainta A.,
   Sanchez-Villegas A., Santiago S., Sayon-Orea C., Schlatter J.,
   Serrano-Martinez M., Toledo E., Toledo J., Tortosa A., Valencia F.,
   Vazquez Z., Zarnowiecki D., Zazpe I. We thank very specially all
   participants in the SUN cohort for their long-standing and enthusiastic
   collaboration and our advisors from Harvard TH Chan School of Public
   Health Walter Willett, Alberto Ascherio, Frank B. Hu, and Meir J.
   Stampfer who helped us to design the SUN Project, the PREDIMED study and
   the PREDIMED-PLUS on-going trial.
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NR 74
TC 188
Z9 192
U1 0
U2 42
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD APR
PY 2018
VL 10
IS 4
AR 439
DI 10.3390/nu10040439
PG 24
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA GJ3HN
UT WOS:000435182900055
PM 29614726
OA gold, Green Submitted, Green Published
HC Y
HP N
DA 2025-06-11
ER

PT J
AU McCarty, MF
AF McCarty, MF
TI Modulation of adipocyte lipoprotein lipase expression as a strategy for
   preventing or treating visceral obesity
SO MEDICAL HYPOTHESES
LA English
DT Review
ID PITUITARY-ADRENAL AXIS; BODY-FAT DISTRIBUTION; FACTOR-BINDING PROTEIN-1;
   GROWTH-FACTOR-I; HORMONE REPLACEMENT THERAPY; TUMOR-NECROSIS-FACTOR;
   HUMAN ADIPOSE-TISSUE; IMPROVES INSULIN-RESISTANCE; SUBCUTANEOUS
   ABDOMINAL FAT; POSTMENOPAUSAL WOMEN
AB As compared to subcutaneous adipocytes, visceral adipocytes have high basal lipolysis, are highly sensitive to catecholamines, and are poorly sensitive to insulin; these traits are amplified when visceral adipocytes hypertrophy. As a result, enlarged visceral fat stores tend to flood the portal circulation with free fatty acids at metabolically inappropriate times when fatty acids are unlikely to be oxidized, thus exposing tissues to excessive free fatty acid levels and giving rise to the insulin resistance syndrome. A logical approach to preventing or correcting visceral obesity is to down-regulate the lipoprotein lipase (LPL) activity of visceral adipocytes relative to that expressed in subcutaneous adipocytes and skeletal muscle. IGF-l activity appears to be a primary determinant of visceral LPL activity in humans; systemic IGF-l activity is decreased when diurnal insulin secretion is low, when hepatocytes detect a relative paucity of certain essential amino acids, and when estrogens are administred orally. The ability of alpha -glucosidase inhibitor therapy to selectively reduce visceral adiposity suggests that down-regulation of diurnal insulin secretion and/or lGF-1 activity may indeed have a greater impact on LPL activity in visceral fat than in subcutaneous fat. Thus, low-glycemic-index, vegan, high-protein, or hypocaloric diets can be expected to decrease visceral LPL activity, as can postmenopausal estrogen therapy. Furthermore, estrogen enhances the LPL activity of non-pathogenic gluteofemoral fat cells, whereas testosterone decreases visceral LPL activity in men; this may explain why sex hormone replacement in middle-aged people of both sexes has a favorable impact on visceral fat and insulin sensitivity. Beta-adrenergic activity suppresses transcription of LPL in adipocytes; this phenomenon may contribute to the favorable impact of exercise training on visceral obesity; conceivably, preadministration of safe drugs that boost catecholamine activity (caffeine, yohimbine) could potentiate this beneficial effect of exercise. Glucocorticoids selectively increase the LPL activity of visceral adipocytes; while there is currently no convincing evidence that psychological stress is a major determinant of visceral adiposity, or that stress management techniques can help to correct visceral obesity, reports that anxiolytic therapy can improve glycemic control in type 2 diabetes should encourage further research along these lines. (C) 2001 Harcourt Publishers Ltd.
C1 Pantox Labs, San Diego, CA 92109 USA.
RP Pantox Labs, 4622 Santa Fe St, San Diego, CA 92109 USA.
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NR 129
TC 25
Z9 32
U1 1
U2 12
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0306-9877
EI 1532-2777
J9 MED HYPOTHESES
JI Med. Hypotheses
PD AUG
PY 2001
VL 57
IS 2
BP 192
EP 200
DI 10.1054/mehy.2001.1317
PG 9
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 456UJ
UT WOS:000170100400014
PM 11461172
DA 2025-06-11
ER

PT J
AU Kampe, T
   Dorko, E
   Rimárová, K
   Houzvicková, A
   Baloghová, J
   Baranová, Z
   Madlenák, M
   Rohon, I
AF Kampe, Tomas
   Dorko, Erik
   Rimarova, Kvetoslava
   Houzvickova, Andrea
   Baloghova, Janette
   Baranova, Zuzana
   Madlenak, Matus
   Rohon, Igor
TI PREVALENCE OF CARDIOVASCULAR RISK FACTORS IN PATIENTS WITH PSORIASIS
SO CENTRAL EUROPEAN JOURNAL OF PUBLIC HEALTH
LA English
DT Article
DE psoriasis; comorbidities; arterial hypertension; depression; diabetes
   mellitus; metabolic syndrome
ID METABOLIC SYNDROME; MORTALITY
AB Objectives: The main goal of the study was to describe the demographic, epidemiological, clinical and laboratory characteristics of a monitored group of patients with psoriasis to assess the prevalence of cardiovascular comorbidities and to define the cardiovascular risk profile.
   Methods: One hundred and ninety outpatients aged over 18 were included in the prospective observational cross-sectional study. Demographic and clinical data were obtained from patients. The severity of psoriasis was evaluated using the Psoriasis Area and Severity Index (PASI) and the Dermatology Life Quality Index (DLQI). The results of laboratory testing were identified based on patient health records.
   Results: Based on an evaluation of psoriasis phenotypes, 150 patients (78.95%) suffered from plaque psoriasis, 18 (9.5%) from palmoplantar psoriasis, 11 (5.8%) from guttate psoriasis, 6 (3.2%) from generalized pustular psoriasis, and 5 (2.6%) from erythrodermic psoriasis. The personal medical history discovered the occurrence of arterial hypertension in 83 patients (43.7%), the occurrence of depression in 49 patients (25.8%), type 2 diabetes in 29 patients (15.3%), and dyslipidaemia in 48 patients (25.3%).
   Conclusion: It is noteworthy that psoriasis may be demonstrated as a multi-system disease which does not only affect the skin and its adnexa. The association of psoriasis with comorbidities may significantly increase morbidity and total mortality as well as the demands for health care provision.
C1 [Kampe, Tomas; Baloghova, Janette; Baranova, Zuzana] Pavol Jozef Safarik Univ, Fac Med, Dept Dermatovenerol, Kosice, Slovakia.
   [Kampe, Tomas; Baloghova, Janette; Baranova, Zuzana] Louis Pasteur Univ Hosp Kosice, Kosice, Slovakia.
   [Dorko, Erik; Rimarova, Kvetoslava; Houzvickova, Andrea] Pavol Jozef Safarik Univ Kosice, Fac Med, Dept Publ Hlth & Hyg, Kosice, Slovakia.
   [Madlenak, Matus; Rohon, Igor] Jessenius Fac Med, Dept Dermatovenerol, Martin, Slovakia.
C3 University of Pavol Jozef Safarik Kosice; University of Pavol Jozef
   Safarik Kosice; Comenius University Bratislava
RP Dorko, E (corresponding author), PJ Safarik Univ Kosice, Fac Med, Dept Publ Hlth & Hyg, Srobarova 2, Kosice 04180, Slovakia.
EM erik.dorko@upjs.sk
RI Rimarova, Kvetoslava/HSH-5269-2023
OI Rimarova, Kvetoslava/0000-0003-4364-0553; Baloghova,
   Janette/0000-0003-4470-5777
FU Ministry of Education, Science, Research and Sport of the Slovak
   Republic [KEGA 007/UPJS-4/2018, KEGA 008UPJS-4/2020, KEGA
   010UPJS-4/2021];  [VVGS IPEL 2020/1485];  [VVGS IPEL 2020/1662]
FX This work was supported by the grants: KEGA 007/UPJS-4/2018, KEGA
   008UPJS-4/2020 and KEGA 010UPJS-4/2021 of the Ministry of Education,
   Science, Research and Sport of the Slovak Republic as well as project
   grants VVGS IPEL 2020/1485 and VVGS IPEL 2020/1662. We also thank the
   Directory Board of University Hospital in Kosice for assistance with the
   organization of sample collection at the hospital wards.
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NR 21
TC 13
Z9 13
U1 0
U2 0
PU NATL INST PUBLIC HEALTH
PI PRAGUE 10
PA DEPT SCIENTIFIC INFORMATION, SROBAROVA 48, PRAGUE 10, 100 42, CZECH
   REPUBLIC
SN 1210-7778
EI 1803-1048
J9 CENT EUR J PUBL HEAL
JI Cent. Eur. J. Public Health
PD JUN
PY 2022
VL 30
SU S
BP S5
EP S10
DI 10.21101/cejph.a6806
PG 6
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA 9Z5CB
UT WOS:000951157900002
PM 35841218
OA Bronze
DA 2025-06-11
ER

PT J
AU Chou, KL
   Yu, KM
AF Chou, Kee-Lee
   Yu, Kar-Ming
TI ATYPICAL DEPRESSIVE SYMPTOMS AND OBESITY IN A NATIONAL SAMPLE OF OLDER
   ADULTS WITH MAJOR DEPRESSIVE DISORDER
SO DEPRESSION AND ANXIETY
LA English
DT Article
DE major depressive disorder; atypical depression; obesity; older adults
ID ALCOHOL-USE DISORDER; PSYCHIATRIC-DISORDERS; EPIDEMIOLOGIC SURVEY;
   METABOLIC SYNDROME; ASSOCIATION; RELIABILITY; PREVALENCE; OVERWEIGHT;
   AUDADIS; COMMUNITY
AB Background The objectives of this study are to present findings on the rate of obesity associated with classic, atypical, and undifferentiated depression by comparing with those without depression in a nationally representative sample of United States older adults. Methods The authors used data from the 2001 to 2002 National Epidemiologic Survey of Alcohol and Related Conditions (NESARC), which included 10,557 adults 60 years of age and older. Chi-square tests were used to compare classic, atypical, and undifferentiated as well as nondepressed control in sociodemographic characteristics. Then, logistic regressions adjusting for sociodemographic characteristics were used to evaluate associations of rate of current obesity (defined as Body Mass Index (BMI) > 30) across the three depressive groups (classic, atypical, and undifferentiated depression) and nondepressed control. Lifetime, current, and past depression were examined. Results Significant differences were found between atypical and classic depression in sex, age, marital status, race, and personal income. After adjusting for sex, age, marital status, race, and personal income, the rate of obesity was significantly greater for respondents with atypical depression than respondents with classic, undifferentiated depression, or without depression. Same results were found in lifetime, current, and past depression. Conclusion Our findings suggest that the heterogeneity of depression should be considered when examining the effect of depression on obesity in old age. Prevention measures should be designed and delivered to older adults with atypical depression. (C) 2013 Wiley Periodicals, Inc.
C1 [Chou, Kee-Lee; Yu, Kar-Ming] Hong Kong Inst Educ, Dept Asian & Policy Studies, Tai Po, Hong Kong, Peoples R China.
C3 Education University of Hong Kong (EdUHK)
RP Chou, KL (corresponding author), Hong Kong Inst Educ, Dept Asian & Policy Studies, 10 Lo Ping Rd, Tai Po, Hong Kong, Peoples R China.
EM klchou@ied.edu.hk
RI Chou, Kee/B-5434-2015
OI Chou, Kee Lee/0000-0003-3627-9915
FU Strategic Public Policy Research [HKU 7002-SPPR-11]; National Institute
   on Drug Abuse
FX Contract grant sponsor: Strategic Public Policy Research; Contract grant
   number: HKU 7002-SPPR-11; Contract grant sponsor: National Institute on
   Drug Abuse.
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NR 38
TC 25
Z9 26
U1 3
U2 22
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1091-4269
EI 1520-6394
J9 DEPRESS ANXIETY
JI Depress. Anxiety
PD JUN
PY 2013
VL 30
IS 6
BP 574
EP 579
DI 10.1002/da.22098
PG 6
WC Psychology, Clinical; Psychiatry; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA 157CC
UT WOS:000319872200009
PM 23554014
OA gold
DA 2025-06-11
ER

PT J
AU Brown, SC
   Lombard, J
   Wang, K
   Byrne, MM
   Toro, M
   Plater-Zyberk, E
   Feaster, DJ
   Kardys, J
   Nardi, MI
   Perez-Gomez, G
   Pantin, HM
   Szapocznik, J
AF Brown, Scott C.
   Lombard, Joanna
   Wang, Kefeng
   Byrne, Margaret M.
   Toro, Matthew
   Plater-Zyberk, Elizabeth
   Feaster, Daniel J.
   Kardys, Jack
   Nardi, Maria I.
   Perez-Gomez, Gianna
   Pantin, Hilda M.
   Szapocznik, Jose
TI Neighborhood Greenness and Chronic Health Conditions in Medicare
   Beneficiaries
SO AMERICAN JOURNAL OF PREVENTIVE MEDICINE
LA English
DT Article
ID CARDIOMETABOLIC RISK-FACTORS; PHYSICAL-ACTIVITY; BUILT ENVIRONMENT;
   OLDER-ADULTS; COMMUNITY DESIGN; MENTAL-HEALTH; WALKING; LIFE;
   ASSOCIATIONS; CHILDREN
AB Introduction: Prior studies suggest that exposure to the natural environment may impact health. The present study examines the association between objective measures of block-level greenness (vegetative presence) and chronic medical conditions, including cardiometabolic conditions, in a large population-based sample of Medicare beneficiaries in Miami-Dade County, Florida.
   Methods: The sample included 249,405 Medicare beneficiaries aged >= 65 years whose location (ZIP+4) within Miami-Dade County, Florida, did not change, from 2010 to 2011. Data were obtained in 2013 and multilevel analyses conducted in 2014 to examine relationships between greenness, measured by mean Normalized Difference Vegetation Index from satellite imagery at the Census block level, and chronic health conditions in 2011, adjusting for neighborhood median household income, individual age, gender, race, and ethnicity.
   Results: Higher greenness was significantly associated with better health, adjusting for covariates: An increase in mean block-level Normalized Difference Vegetation Index from 1 SD less to 1 SD more than the mean was associated with 49 fewer chronic conditions per 1,000 individuals, which is approximately similar to a reduction in age of the overall study population by 3 years. This same level of increase in mean Normalized Difference Vegetation Index was associated with a reduced risk of diabetes by 14%, hypertension by 13%, and hyperlipidemia by 10%. Planned post-hoc analyses revealed stronger and more consistently positive relationships between greenness and health in lower-than higher-income neighborhoods.
   Conclusions: Greenness or vegetative presence may be effective in promoting health in older populations, particularly in poor neighborhoods, possibly due to increased time outdoors, physical activity, or stress mitigation. (C) 2016 American Journal of Preventive Medicine. Published by Elsevier Inc. All rights reserved.
C1 [Brown, Scott C.; Lombard, Joanna; Wang, Kefeng; Byrne, Margaret M.; Toro, Matthew; Plater-Zyberk, Elizabeth; Feaster, Daniel J.; Perez-Gomez, Gianna; Pantin, Hilda M.; Szapocznik, Jose] Univ Miami, Dept Publ Hlth Sci, Miller Sch Med, 1120 NW 14th St,Clin Res Bldg CRB,Room 106, Miami, FL 33136 USA.
   [Brown, Scott C.; Lombard, Joanna; Plater-Zyberk, Elizabeth; Szapocznik, Jose] Univ Miami, Sch Architecture, Coral Gables, FL 33124 USA.
   [Kardys, Jack; Nardi, Maria I.] Miami Dade Cty Dept Parks Recreat & Open Spaces, Miami, FL USA.
C3 University of Miami; University of Miami
RP Brown, SC (corresponding author), Univ Miami, Dept Publ Hlth Sci, Miller Sch Med, 1120 NW 14th St,Clin Res Bldg CRB,Room 106, Miami, FL 33136 USA.
EM sbrown@med.miami.edu
RI Wang, Kefeng/T-7938-2017
OI Toro, Matthew/0000-0001-9605-5732; Lombard, Joanna/0000-0002-4925-9633
FU U.S. Department of Housing & Urban Development [HUD H-21620-RG]; Health
   Foundation of South Florida
FX This project was supported in part by a grant from the U.S. Department
   of Housing & Urban Development, Grant Number HUD H-21620-RG (Contact
   Principal Investigator [PI]: S. Brown) and the Health Foundation of
   South Florida (PI: S. Brown). The funders had no role in study design,
   data collection, data analysis, data interpretation, or writing of the
   report. The corresponding author (SB) and third author (KW) had full
   access to all of the data in the study and take responsibility for the
   integrity of the data and the accuracy of the data analysis. KW
   conducted the statistical analyses. The corresponding author (SB) takes
   responsibility for the decision to submit for publication. All authors
   agreed with the decision to submit the paper.
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NR 48
TC 132
Z9 142
U1 6
U2 62
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0749-3797
EI 1873-2607
J9 AM J PREV MED
JI Am. J. Prev. Med.
PD JUL
PY 2016
VL 51
IS 1
BP 78
EP 89
DI 10.1016/j.amepre.2016.02.008
PG 12
WC Public, Environmental & Occupational Health; Medicine, General &
   Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; General & Internal Medicine
GA DO8VR
UT WOS:000378063800012
PM 27061891
DA 2025-06-11
ER

PT J
AU Kushner, P
   Kahan, S
   Mcintyre, RS
AF Kushner, Pamela
   Kahan, Scott
   Mcintyre, Roger S.
TI Treating obesity in patients with depression: a narrative review and
   treatment recommendation
SO POSTGRADUATE MEDICINE
LA English
DT Review
DE Clinical decision-making; primary care; obesity; depression; pain;
   fatigue; weight loss
ID WEIGHT-LOSS; BODY-WEIGHT; PRACTICE GUIDELINES; MAJOR DEPRESSION;
   AMERICAN-COLLEGE; SUBSTANCE USE; RISK-FACTORS; TASK-FORCE; OVERWEIGHT;
   ADULTS
AB The high morbidity of obesity and depression pose significant public health concerns, with the prevalence of obesity doubling in the US between 1990 and 2022 and patients frequently presenting with both. Untreated obesity and depression can greatly impact patient health and well-being, as both obesity and depression are associated with a number of comorbidities including sleep apnea, type 2 diabetes mellitus, metabolic syndrome, metabolic dysfunction-associated steatotic liver disease, and cardiovascular disease. This narrative review aims to provide a comprehensive and current overview of the overlapping etiologies between obesity and depression as well as the available treatment options that may be recommended by primary care professionals to treat these patients with concomitant obesity and depression. With the considerable overlap in the population of patients with obesity and depression, as well as the overlap in the neurobiological, hormonal, and inflammatory pathways underlying both diseases, primary care professionals should consider screening patients presenting with obesity for depression. Holistic treatment options, including lifestyle and behavioral modifications, and pharmacotherapy for both depression and obesity and bariatric surgery for obesity are critical to manage both conditions simultaneously. Therefore, due to the overlapping neurobiological pathways and mechanisms responsible for the incidence and progression of both obesity and depression, a holistic treatment plan including strategies with efficacy for both conditions and any additional comorbidities may improve the clinical approach for patients with concomitant obesity and depression.
C1 [Kushner, Pamela] Univ Calif Irvine, Med Ctr, Dept Family Med, Irvine, CA USA.
   [Kushner, Pamela] Kushner Wellness Ctr, Los Angeles, CA USA.
   [Kahan, Scott] George Washington Univ, Sch Med, Washington, DC USA.
   [Mcintyre, Roger S.] Univ Toronto, Dept Psychiat, 250 Coll St,8th Floor, Toronto, ON MNT 1R8, Canada.
C3 University of California System; University of California Irvine; George
   Washington University; University of Toronto
RP Mcintyre, RS (corresponding author), Univ Toronto, Dept Psychiat, 250 Coll St,8th Floor, Toronto, ON MNT 1R8, Canada.
EM roger.mcintyre@bcdf.org
RI McIntyre, Roger/AAU-1000-2020
FU Currax Pharmaceuticals, LLC
FX The authors were not compensated for their participation in this
   project. Medical writing and editorial support were funded by Currax
   Pharmaceuticals, LLC.
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NR 170
TC 0
Z9 0
U1 3
U2 3
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0032-5481
EI 1941-9260
J9 POSTGRAD MED
JI Postgrad. Med.
PD MAY 19
PY 2025
VL 137
IS 3-4
BP 221
EP 234
DI 10.1080/00325481.2025.2478812
EA MAR 2025
PG 14
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 2TE7W
UT WOS:001451122800001
PM 40106726
DA 2025-06-11
ER

PT J
AU Hajhashemy, Z
   Mirenayat, FS
   Siavash, M
   Saneei, P
AF Hajhashemy, Zahra
   Mirenayat, Fateme Sadat
   Siavash, Mansour
   Saneei, Parvane
TI The effect of sumac supplementation on insulin resistance, inflammation,
   oxidative stress, and antioxidant capacity in adults with metabolic
   syndrome: A randomized crossover clinical trial
SO PHYTOTHERAPY RESEARCH
LA English
DT Article
DE antioxidant capacity; inflammation; insulin resistance; metabolic
   syndrome; oxidative stress; randomized clinical trial; sumac
ID RHUS-CORIARIA-L.; BIOLOGICAL-ACTIVITIES; EXTRACT; OBESITY; POWDER
AB The impact of sumac supplementation was not previously examined in patients with metabolic syndrome (MetS). So, we investigated the influence of sumac supplementation on insulin resistance, inflammation, oxidative stress, and antioxidant markers in adults with MetS. The current study was a single-center, triple-blind, randomized, placebo-controlled crossover clinical trial that was conducted on 47 patients with MetS. Participants were randomly divided into two groups of intervention and control in the first phase. They received capsules containing 500 mg sumac or placebo (lactose) twice a day, after lunch and dinner, for 6 weeks. After a 2-week washout period, the subjects crossed over to the alternate arm. In both arms, fasting venous blood samples were obtained at baseline and at the sixth week of the intervention to determine glycemic status, high-sensitivity C-reactive protein (hs-CRP), malondialdehyde (MDA), total antioxidant capacity (TAC), and antioxidant enzymes activity. The mean (+/- SD) age, weight, and body mass index of participants were respectively 58.7 +/- 5.83 years, 79.9 +/- 14.35 kg, and 31.6 +/- 4.6 kg/m(2); 80.9% of subjects were females (n = 38). Based on per-protocol analyses, the serum fasting insulin concentration was unexpectedly decreased in the placebo group (change in sumac vs. control: 0.95 +/- 3.9 vs. -1.17 +/- 3.9 mU/L; p = 0.04). Sumac supplementation, compared to control, has marginally enhanced catalase activity (change in sumac vs. control: 2.91 +/- 9.5 vs. -1.07 +/- 9.1 nmol/min/ml; p = 0.06). This supplementation has also increased serum TAC and the activity of superoxide dismutase, but these changes were not significant. This intervention did not affect other insulin resistance, inflammatory, or oxidative stress markers. We found that 1 g/day sumac consumption for 6 weeks, as adjuvant therapy, could improve the antioxidant defense system in adults with MetS but did not affect insulin resistance, inflammation, or oxidative stress.
C1 [Hajhashemy, Zahra; Mirenayat, Fateme Sadat] Isfahan Univ Med Sci, Student Res Comm, Esfahan, Iran.
   [Hajhashemy, Zahra; Mirenayat, Fateme Sadat; Saneei, Parvane] Isfahan Univ Med Sci, Nutr & Food Secur Res Ctr, Sch Nutr & Food Sci, Dept Community Nutr, POB 81745-151, Esfahan, Iran.
   [Siavash, Mansour] Isfahan Univ Med Sci, Isfahan Endocrine & Metab Res Ctr, Esfahan, Iran.
C3 Isfahan University of Medical Sciences; Isfahan University of Medical
   Sciences; Isfahan University of Medical Sciences
RP Saneei, P (corresponding author), Isfahan Univ Med Sci, Nutr & Food Secur Res Ctr, Sch Nutr & Food Sci, Dept Community Nutr, POB 81745-151, Esfahan, Iran.
EM saneeip@yahoo.com
RI Siavash, Mansour/C-8151-2018; Saneei, Parvane/T-5434-2019
OI Hajhashemy, Zahra/0000-0002-4312-0294; Saneei,
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NR 41
TC 6
Z9 6
U1 1
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0951-418X
EI 1099-1573
J9 PHYTOTHER RES
JI Phytother. Res.
PD APR
PY 2023
VL 37
IS 4
BP 1319
EP 1329
DI 10.1002/ptr.7688
EA NOV 2022
PG 11
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA D5KZ9
UT WOS:000889660900001
PM 36428227
DA 2025-06-11
ER

PT J
AU Gamble, KL
   Motsinger-Reif, AA
   Hida, A
   Borsetti, HM
   Servick, SV
   Ciarleglio, CM
   Robbins, S
   Hicks, J
   Carver, K
   Hamilton, N
   Wells, N
   Summar, ML
   McMahon, DG
   Johnson, CH
AF Gamble, Karen L.
   Motsinger-Reif, Alison A.
   Hida, Akiko
   Borsetti, Hugo M.
   Servick, Stein V.
   Ciarleglio, Christopher M.
   Robbins, Sam
   Hicks, Jennifer
   Carver, Krista
   Hamilton, Nalo
   Wells, Nancy
   Summar, Marshall L.
   McMahon, Douglas G.
   Johnson, Carl Hirschie
TI Shift Work in Nurses: Contribution of Phenotypes and Genotypes to
   Adaptation
SO PLOS ONE
LA English
DT Article
ID CIRCADIAN CLOCK GENES; SLEEP-PHASE SYNDROME; NIGHT SHIFTS; T3111C
   POLYMORPHISM; LENGTH POLYMORPHISM; METABOLIC SYNDROME; PER3 GENE;
   ASSOCIATION; MOOD; DISORDER
AB Background: Daily cycles of sleep/wake, hormones, and physiological processes are often misaligned with behavioral patterns during shift work, leading to an increased risk of developing cardiovascular/metabolic/gastrointestinal disorders, some types of cancer, and mental disorders including depression and anxiety. It is unclear how sleep timing, chronotype, and circadian clock gene variation contribute to adaptation to shift work.
   Methods: Newly defined sleep strategies, chronotype, and genotype for polymorphisms in circadian clock genes were assessed in 388 hospital day-and night-shift nurses.
   Results: Night-shift nurses who used sleep deprivation as a means to switch to and from diurnal sleep on work days (similar to 25%) were the most poorly adapted to their work schedule. Chronotype also influenced efficacy of adaptation. In addition, polymorphisms in CLOCK, NPAS2, PER2, and PER3 were significantly associated with outcomes such as alcohol/caffeine consumption and sleepiness, as well as sleep phase, inertia and duration in both single-and multi-locus models. Many of these results were specific to shift type suggesting an interaction between genotype and environment (in this case, shift work).
   Conclusions: Sleep strategy, chronotype, and genotype contribute to the adaptation of the circadian system to an environment that switches frequently and/or irregularly between different schedules of the light-dark cycle and social/workplace time. This study of shift work nurses illustrates how an environmental "stress'' to the temporal organization of physiology and metabolism can have behavioral and health-related consequences. Because nurses are a key component of health care, these findings could have important implications for health-care policy.
C1 [Gamble, Karen L.; Hida, Akiko; Borsetti, Hugo M.; Servick, Stein V.; McMahon, Douglas G.; Johnson, Carl Hirschie] Vanderbilt Univ, Dept Biol Sci, Nashville, TN USA.
   [Motsinger-Reif, Alison A.] N Carolina State Univ, Dept Stat, Raleigh, NC 27695 USA.
   [Ciarleglio, Christopher M.] Vanderbilt Univ, Grad Program Neurosci, Nashville, TN USA.
   [Robbins, Sam; Hicks, Jennifer; Carver, Krista; Hamilton, Nalo; Wells, Nancy] Vanderbilt Univ, Vanderbilt Sch Nursing, Nashville, TN USA.
   [Summar, Marshall L.; Johnson, Carl Hirschie] Childrens Natl Med Ctr, Washington, DC 20010 USA.
C3 Vanderbilt University; North Carolina State University; Vanderbilt
   University; Vanderbilt University; Children's National Health System
RP Gamble, KL (corresponding author), Univ Alabama Birmingham, Dept Psychiat & Behav Neurobiol, Birmingham, AL 35294 USA.
EM carl.h.johnson@vanderbilt.edu
RI Johnson, Carl/I-4655-2014; Gamble, Karen/A-1753-2010; Ciarleglio,
   Christopher/D-8463-2013; Motsinger-Reif, Alison/I-4167-2018
OI Summar, Marshall/0000-0001-8920-0110; Ciarleglio,
   Christopher/0000-0002-8490-8715; McMahon, Douglas/0000-0002-0645-2281;
   Motsinger-Reif, Alison/0000-0003-1346-2493; Gamble,
   Karen/0000-0003-3813-8577
FU Vanderbilt University; National Center for Research Resources of the
   National Institutes of Health [M01 RR-00095]; Vanderbilt Joint Center
   for Nursing Research [U01 HL065962]; National Institute of Mental Health
   [R01 MH043836, R21 MH082258, P50 MH07080828, K99 GM086683];
   Grants-in-Aid for Scientific Research [22791161, 21390335] Funding
   Source: KAKEN
FX This research was supported by a Discovery Grant from Vanderbilt
   University, a grant from the National Center for Research Resources of
   the National Institutes of Health to Vanderbilt's General Clinical
   Research Center (M01 RR-00095), the Vanderbilt Joint Center for Nursing
   Research, U01 HL065962 (to Dr. Dan Roden), and grants from the National
   Institute of Mental Health (R01 MH043836 and R21 MH082258 to CHJ, P50
   MH07080828 to DGM, and K99 GM086683 to KLG). The funders had no role in
   study design, data collection and analysis, decision to publish, or
   preparation of the manuscript.
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NR 74
TC 138
Z9 151
U1 1
U2 49
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD APR 13
PY 2011
VL 6
IS 4
AR e18395
DI 10.1371/journal.pone.0018395
PG 12
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Science & Technology - Other Topics
GA 749IP
UT WOS:000289458800010
PM 21533241
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Lim, JH
   Kim, Y
   Kim, MY
   Kim, EN
   Kim, TW
   Choi, BS
   Kim, WU
   Kim, HW
   Park, JY
   Park, CW
AF Lim, Ji Hee
   Kim, Yaeni
   Kim, Min Young
   Kim, Eun Nim
   Kim, Tae Woo
   Choi, Bum Soon
   Kim, Wan-Uk
   Kim, Hye Won
   Park, Ji Yong
   Park, Cheol Whee
TI Placental growth factor deficiency initiates obesity- and
   aging-associated metabolic syndrome
SO METABOLISM-CLINICAL AND EXPERIMENTAL
LA English
DT Article
DE Adipose tissue; AMP-activated protein kinase; Metabolic syndrome;
   Metformin; Placental growth factor
ID ACTIVATED PROTEIN-KINASE; ENDOTHELIAL-CELLS; INSULIN-RESISTANCE;
   ADIPOSE-TISSUE; ANGIOGENESIS; EXPRESSION; AMPK; HOMEOSTASIS; METFORMIN;
   PROMOTES
AB Obesity often leads to inadequate angiogenesis in expanding adipose tissue, resulting in inflammation and insulin resistance. We explored the role of placental growth factor (PlGF) in metabolic syndrome (MS) using mice models of type 2 diabetes, high-fat diet, or aging. Reduced serum PlGF levels were associated with decreased insulin sensitivity and development of MS features. PlGF was localized within endothelial cells and pericytes of adipose tissue. In vitro, low PlGF levels in hypoxic conditions worsened oxidative stress, apoptosis, and reduced autophagy. This was associated with a reduction in expression of vascular endothelial growth factor (VEGF)-A/VEGFR1/-R2, which was influenced by a decrease and increase in PlGF/pAMPK/PI3K-pAkt/PLC gamma 1-iCa++/eNOS and PTEN/GSK3(3 axes, respectively. PlGF-knockout mice exhibited MS traits through alterations in the same signaling pathways, and these changes were mitigated by recombinant PlGF and metformin. These enhanced angiogenesis and lipid metabolism, underscoring PlGF's role in age-related MS and its potential as a therapeutic target.
C1 [Lim, Ji Hee; Kim, Yaeni; Kim, Min Young; Kim, Eun Nim; Kim, Tae Woo; Choi, Bum Soon; Park, Cheol Whee] Catholic Univ Korea, Coll Med, Dept Internal Med, Div Nephrol, Seoul, South Korea.
   [Lim, Ji Hee; Kim, Min Young; Park, Cheol Whee] Catholic Univ Korea, Inst Aging & Metab Dis, Coll Med, Seoul, South Korea.
   [Kim, Wan-Uk] Catholic Univ Korea, Coll Med, Dept Internal Med, Div Rheumatol, Seoul, South Korea.
   [Kim, Hye Won] Catholic Univ Korea, Coll Med, Bucheon St Marys Hosp, Dept Rehabil Med, Bucheon, South Korea.
   [Park, Ji Yong] Korea Univ, Dept Psychol, Seoul, South Korea.
C3 Catholic University of Korea; Catholic University of Korea; Catholic
   University of Korea; Catholic University of Korea; Korea University
RP Park, CW (corresponding author), Catholic Univ Korea, Seoul St Marys Hosp, Coll Med, Dept Internal Med, 222,Banpo Daero, Seoul 06591, South Korea.
EM cheolwhee@hanmail.net
RI Kim, Wan-Uk/AAO-8502-2020
FU National Research Foundation of Korea (NRF) - Ministry of Education,
   Science, and Technology [RS-2023-00249560, NRF-2022R1I1A1A01065499,
   RS-2023-00251436]
FX The PlGF-KO mice were provided by Dr. Seung-Ah Yoo. We thank Dr. Yoo for
   her invaluable support in executing this project. This study was
   supported by grants from the Basic Science Research Program through the
   National Research Foundation of Korea (NRF) funded by the Ministry of
   Education, Science, and Technology (JHL; RS-2023-00249560, YK;
   NRF-2022R1I1A1A01065499, CWP; RS-2023-00251436).
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NR 52
TC 2
Z9 2
U1 2
U2 2
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0026-0495
EI 1532-8600
J9 METABOLISM
JI Metab.-Clin. Exp.
PD DEC
PY 2024
VL 161
AR 156002
DI 10.1016/j.metabol.2024.156002
EA OCT 2024
PG 42
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA L0G0C
UT WOS:001347580200001
PM 39173826
DA 2025-06-11
ER

PT J
AU Garcìa-Llorca, A
   Kararigas, G
AF Garcia-Llorca, Andrea
   Kararigas, Georgios
TI Sex-Related Effects of Gut Microbiota in Metabolic Syndrome-Related
   Diabetic Retinopathy
SO MICROORGANISMS
LA English
DT Review
DE biological sex; biomarkers; cardiovascular disease; diabetic
   retinopathy; gut microbiota; metabolic syndrome
ID GENDER-DIFFERENCES; INSULIN-RESISTANCE; DEPENDENT REGULATION;
   ADIPOSE-TISSUE; HEART-FAILURE; PROTEOMIC ANALYSIS; OXIDATIVE STRESS;
   CARDIAC GROWTH; RISK-FACTORS; TYPE-2
AB The metabolic syndrome (MetS) is a complex disease of metabolic abnormalities, including obesity, insulin resistance, hypertension and dyslipidaemia, and it is associated with an increased risk of cardiovascular disease (CVD). Diabetic retinopathy (DR) is the leading cause of vision loss among working-aged adults around the world and is the most frequent complication in type 2 diabetic (T2D) patients. The gut microbiota are a complex ecosystem made up of more than 100 trillion of microbial cells and their composition and diversity have been identified as potential risk factors for the development of several metabolic disorders, including MetS, T2D, DR and CVD. Biomarkers are used to monitor or analyse biological processes, therapeutic responses, as well as for the early detection of pathogenic disorders. Here, we discuss molecular mechanisms underlying MetS, the effects of biological sex in MetS-related DR and gut microbiota, as well as the latest advances in biomarker research in the field. We conclude that sex may play an important role in gut microbiota influencing MetS-related DR.
C1 [Garcia-Llorca, Andrea; Kararigas, Georgios] Univ Iceland, Fac Med, Dept Physiol, IS-101 Reykjavik, Iceland.
C3 University of Iceland
RP Kararigas, G (corresponding author), Univ Iceland, Fac Med, Dept Physiol, IS-101 Reykjavik, Iceland.
EM georgekararigas@gmail.com
RI García-Llorca, Andrea/ISU-7279-2023
OI Kararigas, Georgios/0000-0002-8187-0176; Garcia-Llorca,
   Andrea/0000-0001-8137-1513
FU Icelandic Research Fund [217946-051]; Icelandic Cancer Society Research
   Fund; University of Iceland Research Fund; Postdoctoral Fellowship grant
   from the Icelandic Research Fund [217796-052]
FX G.K. acknowledges lab support provided by grants from the Icelandic
   Research Fund (217946-051), the Icelandic Cancer Society Research Fund
   and the University of Iceland Research Fund. A.G.L. acknowledges
   financial support provided by a Postdoctoral Fellowship grant from the
   Icelandic Research Fund (217796-052).
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NR 199
TC 7
Z9 7
U1 1
U2 6
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-2607
J9 MICROORGANISMS
JI Microorganisms
PD FEB
PY 2023
VL 11
IS 2
AR 447
DI 10.3390/microorganisms11020447
PG 18
WC Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Microbiology
GA 9L3OG
UT WOS:000941461100001
PM 36838411
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Lioudaki, E
   Ganotakis, ES
   Mikhailidis, DP
AF Lioudaki, Eirini
   Ganotakis, Emmanuel S.
   Mikhailidis, Dimitri P.
TI Liver Enzymes: Potential Cardiovascular Risk Markers?
SO CURRENT PHARMACEUTICAL DESIGN
LA English
DT Review
DE Liver enzyme; alanine aminotransferase; gamma-glutamyltransferase;
   aspartate aminotransferase; non-alcoholic fatty liver disease;
   cardiovascular disease; cardiovascular risk; metabolic syndrome;
   diabetes mellitus
ID GAMMA-GLUTAMYL-TRANSFERASE; NONALCOHOLIC FATTY LIVER; SERUM ALANINE
   AMINOTRANSFERASE; TYPE-2 DIABETES-MELLITUS; C-REACTIVE PROTEIN;
   INSULIN-RESISTANCE ATHEROSCLEROSIS; KOREAN NATIONAL-HEALTH;
   CORONARY-HEART-DISEASE; METABOLIC SYNDROME; MYOCARDIAL-INFARCTION
AB Several cross-sectional studies have reported a relationship between elevated serum activity of liver enzymes [e.g. alanine aminotransferase (ALT) and gamma-glutamyltransferase (gamma GT)] and metabolic syndrome (MetS) and/or diabetes mellitus (DM). Raised serum activity of liver enzymes independently predicted the future development of MetS and DM as well as cardiovascular (CV) events and/or total/CV mortality in prospective studies. However, this association was not consistently demonstrated and it appears to be independent of alcohol intake. Even though these associations can be partly attributed to non-alcoholic fatty liver disease (NAFLD) and insulin resistance, there may be additional underlying mechanisms that contribute to the increased CV risk (e.g. inflammation and oxidative stress). The association of gamma GT with atherosclerotic plaque is of particular importance.
   The present review considers the link between serum liver enzyme activities and vascular risk. The links with DM and MetS are also discussed.
C1 [Lioudaki, Eirini; Mikhailidis, Dimitri P.] UCL, Dept Clin Biochem, Univ Coll London Med Sch, Vasc Dis Prevent Clin, London NW3 2QG, England.
   [Lioudaki, Eirini; Ganotakis, Emmanuel S.] Univ Crete, Dept Internal Med, Iraklion, Crete, Greece.
   [Lioudaki, Eirini; Ganotakis, Emmanuel S.] Sch Med, Iraklion, Crete, Greece.
C3 University of London; University College London; University of Crete;
   University of Crete
RP Mikhailidis, DP (corresponding author), UCL, Dept Clin Biochem, Univ Coll London Med Sch, Vasc Dis Prevent Clin, Royal Free Hosp Campus, London NW3 2QG, England.
EM mikhailidis@aol.com
RI Mikhailidis, Dimitri/A-1869-2013
OI Lioudaki, Eirini/0000-0001-7363-642X; GANOTAKIS,
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NR 108
TC 52
Z9 52
U1 0
U2 18
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1381-6128
EI 1873-4286
J9 CURR PHARM DESIGN
JI Curr. Pharm. Design
PD NOV
PY 2011
VL 17
IS 33
BP 3632
EP 3643
DI 10.2174/138161211798220945
PG 12
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 883MJ
UT WOS:000299638000004
PM 22074433
DA 2025-06-11
ER

PT J
AU Lou, N
   Wu, X
   Wang, Y
   Lou, D
AF Lou, Nanfang
   Wu, Xiang
   Wang, Yingmin
   Lou, Dongdong
TI Liraglutide improves postprandial blood glucose, blood glucose levels,
   insulin resistance and physical distribution of T2DM patients with MS
SO INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
LA English
DT Article
DE Liraglutide; type 2 diabetes mellitus complicated with metabolic
   syndrome; insulin resistance; oxidative stress; physical distribution
ID TYPE-2 DIABETES-MELLITUS; METABOLIC SYNDROME; OXIDATIVE STRESS;
   ASSOCIATION; POPULATION; INJURY
AB Objective: This study aimed to investigate the efficacy of Liraglutide on insulin resistance, physical distribution and oxidative stress level in patients with type 2 diabetes mellitus (T2DM) complicated with metabolic syndrome (MS). Methods: In total, 86 patients with T2DM complicated with MS in our hospital were selected as the study subjects. The patients were divided into control group (CG) (n = 43) and research group (RG) (n = 43) in accordance with a random number table. The patients in the CG received metformin. The patients in RG received Liraglutide. Blood glucose levels, blood lipid levels, insulin resistance, physical distribution, oxidative stress levels were compared between the two groups. Results: FBG, 2hPPG and HbA1c in both groups dramatically decreased after treatment. The three measures in RG were lower than those in CG (P < 0.05). TG, TC and LDL-C levels reduced and HDL-C level increased. The TG, TC and LDL-C levels in CG were higher than those in RG (P < 0.05). HOMA-beta reduced and HOMA-beta increased. The level of HOMA-beta in RG was lower than that in CG (P < 0.05). The level of HOMA-beta was higher than that in CG (P < 0.05). Weight, body mass index and waistline reduced. The three measures in CG were higher than those in RG (P < 0.05). Urine 8-isoprostaines F2 alpha and MDA remarkably reduced and T-AOC significantly increased compared with those before treatment. The 8-isoprostaines F2 alpha and MDA in RG were lower than those in CG (P < 0.05). The level of T-AOC was higher than that in CG (P < 0.05). Conclusion: Liraglutide can significantly improve the postprandial blood glucose, blood glucose level, insulin resistance and physical distribution of T2DM patients with MS. Its effect may be related to the improvement of oxidative stress levels in the body.
C1 [Lou, Nanfang; Wu, Xiang; Wang, Yingmin] Tongde Hosp Zhejiang Prov, Dept Endocrinol, Hangzhou, Zhejiang, Peoples R China.
   [Lou, Dongdong] Geriatr Hosp Zhejiang Prov, Dept Internal Med, 21 Jinhua Rd, Hangzhou 310015, Zhejiang, Peoples R China.
RP Lou, D (corresponding author), Geriatr Hosp Zhejiang Prov, Dept Internal Med, 21 Jinhua Rd, Hangzhou 310015, Zhejiang, Peoples R China.
EM dongdonglou100@163.com
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NR 26
TC 1
Z9 1
U1 0
U2 1
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 1940-5901
J9 INT J CLIN EXP MED
JI Int. J. Clin. Exp. Med.
PY 2020
VL 13
IS 2
BP 518
EP 524
PG 7
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA KS6DO
UT WOS:000518397600021
DA 2025-06-11
ER

PT J
AU Agil, A
   Reiter, RJ
   Jiménez-Aranda, A
   Ibán-Arias, R
   Navarro-Alarcón, M
   Marchal, JA
   Adem, A
   Fernández-Vázquez, G
AF Agil, Ahmad
   Reiter, Russel J.
   Jimenez-Aranda, Aroa
   Iban-Arias, Ruth
   Navarro-Alarcon, Miguel
   Antonio Marchal, Juan
   Adem, Abdu
   Fernandez-Vazquez, Gumersindo
TI Melatonin ameliorates low-grade inflammation and oxidative stress in
   young Zucker diabetic fatty rats
SO JOURNAL OF PINEAL RESEARCH
LA English
DT Article
DE low-grade inflammation; melatonin; oxidative stress; Zucker diabetic
   fatty rats
ID REACTIVE OXYGEN; SYSTEMIC INFLAMMATION; INSULIN-RESISTANCE; METABOLIC
   SYNDROME; ADIPOSE-TISSUE; VISCERAL FAT; BETA-CELL; OBESITY; EXERCISE;
   PLASMA
AB The aim of this study was to investigate the effects of melatonin on low-grade inflammation and oxidative stress in young male Zucker diabetic fatty (ZDF) rats, an experimental model of metabolic syndrome and type 2 diabetes mellitus (T2DM). ZDF rats (n=30) and lean littermates (ZL) (n=30) were used. At 6wk of age, both lean and fatty animals were subdivided into three groups, each composed of 10 rats: naive (N), vehicle treated (V), and melatonin treated (M) (10mg/kg/day) for 6wk. Vehicle and melatonin were added to the drinking water. Pro-inflammatory state was evaluated by plasma levels of interleukin-6 (IL-6), tumor necrosis factor- (TNF-), and C-reactive protein (CRP). Also, oxidative stress was assessed by plasma lipid peroxidation (LPO), both basal and after Fe2+/H2O2 inducement. ZDF rats exhibited higher levels of IL-6 (112.4 +/- 1.5pg/mL), TNF- (11.0 +/- 0.1pg/mL) and CRP (828 +/- 16.0 mu g/mL) compared with lean rats (IL-6, 89.9 +/- 1.0, P<0.01; TNF-, 9.7 +/- 0.4, P<0.01; CRP, 508 +/- 21.5, P<0.001). Melatonin lowered IL-6 (10%, P<0.05), TNF- (10%, P<0.05), and CRP (21%, P<0.01). Basal and Fe2+/H2O2-induced LPO, expressed as malondialdehyde equivalents (mu mol/L), were higher in ZDF rats (basal, 3.2 +/- 0.1 versus 2.5 +/- 0.1 in ZL, P<0.01; Fe2+/H2O2-induced, 8.7 +/- 0.2 versus 5.5 +/- 0.3 in ZL; P<0.001). Melatonin improved basal LPO (15%, P<0.05) in ZDF rats, and Fe2+/H2O2- induced LPO in both ZL (15.2%, P<0.01) and ZDF rats (39%, P<0.001). These results demonstrated that oral melatonin administration ameliorates the pro-inflammatory state and oxidative stress, which underlie the development of insulin resistance and their consequences, metabolic syndrome, diabetes, and cardiovascular disease.
C1 [Agil, Ahmad; Jimenez-Aranda, Aroa; Iban-Arias, Ruth] Univ Granada, Sch Med, Dept Pharmacol, E-18012 Granada, Spain.
   [Agil, Ahmad; Jimenez-Aranda, Aroa; Iban-Arias, Ruth] Univ Granada, Sch Med, Neurosci Inst, E-18012 Granada, Spain.
   [Reiter, Russel J.] Univ Texas Hlth Sci Ctr San Antonio, Dept Cellular & Struct Biol, San Antonio, TX 78229 USA.
   [Navarro-Alarcon, Miguel] Univ Granada, Sch Pharm, Dept Nutr & Food Sci, E-18012 Granada, Spain.
   [Antonio Marchal, Juan] Univ Granada, Sch Med, Biopathol Inst, Biomed Res Ctr, E-18012 Granada, Spain.
   [Antonio Marchal, Juan] Univ Granada, Sch Med, Regenerat Med IBIMER, E-18012 Granada, Spain.
   [Adem, Abdu] United Arab Emirates Univ, Fac Med & Hlth Sci, Dept Pharmacol, Al Ain, U Arab Emirates.
   [Fernandez-Vazquez, Gumersindo] Carlos III Hosp, Serv Endocrinol, Madrid, Spain.
C3 University of Granada; University of Granada; University of Texas
   System; University of Texas Health Science Center at San Antonio;
   University of Granada; University of Granada; University of Granada;
   United Arab Emirates University; Hospital Carlos III
RP Agil, A (corresponding author), Univ Granada, Sch Med, Dept Pharmacol, E-18012 Granada, Spain.
EM aagil@ugr.es
RI Vázquez, Gumersindo/AAB-3317-2019; Adem, Abdu/AAN-8271-2021; Agil,
   Ahmad/D-9620-2014; Reiter, Russel/D-3221-2009; Navarro-Alarcon,
   Miguel/Q-4368-2019; Marchal, Juan Antonio/M-4305-2014; Navarro-Alarcon,
   Miguel/K-6646-2014
OI Agil, Ahmad/0000-0003-0164-9648; Marchal, Juan
   Antonio/0000-0002-4996-8261; Navarro-Alarcon, Miguel/0000-0002-3189-3310
FU vice-rectorado de Investigacion (Universidad de Granada) [Plan
   Propio-2011]; Junta de Andalucia (Spain) [CTS-109]
FX This work was partially supported by grant Plan Propio-2011,
   vice-rectorado de Investigacion (Universidad de Granada) and CTS-109
   group from the Junta de Andalucia (Spain). The authors thank Antonio
   Tirado for his technical assistance. Abdu Adem was visiting Scientist
   from University of United Arab Emirates, Al Ain, United Arab Emirates.
   Aroa Jimenez was supported by a collaboration-contract from CTS-109
   group (led by Professor Jose Manuel Baeyens) from the Junta de Andalucia
   (Spain). The experiment was approved by the Ethical Committee of the
   University of Granada (Granada, Spain) according to European Union
   guidelines.
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NR 65
TC 110
Z9 116
U1 0
U2 20
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0742-3098
EI 1600-079X
J9 J PINEAL RES
JI J. Pineal Res.
PD MAY
PY 2013
VL 54
IS 4
BP 381
EP 388
DI 10.1111/jpi.12012
PG 8
WC Endocrinology & Metabolism; Neurosciences; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Physiology
GA 270BO
UT WOS:000328291900003
PM 23020082
DA 2025-06-11
ER

PT J
AU Scandar, S
   Zadra, C
   Marcotullio, MC
AF Scandar, Samir
   Zadra, Claudia
   Marcotullio, Maria Carla
TI Coriander (Coriandrum sativum) Polyphenols and Their
   Nutraceutical Value against Obesity and Metabolic Syndrome
SO MOLECULES
LA English
DT Review
DE Coriandrum sativum L; polyphenols; antioxidant activity;
   anti-inflammatory activity; obesity; metabolic syndrome; diabetes
ID PARSLEY PETROSELINUM-CRISPUM; ESSENTIAL OIL COMPOSITION; L. ESSENTIAL
   OIL; PHENOLIC-COMPOUNDS; ANTIOXIDANT ACTIVITIES; OXIDATIVE STRESS;
   CARUM-CARVI; EXTRACTION; SEEDS; OPTIMIZATION
AB Coriander is a widely used plant for its medicinal and biological properties. Both coriander essential oil and extracts are interesting sources of bioactive compounds and are widely used as spices in culinary practice due to their exclusive aroma and flavour. We focus our attention on coriander extracts that are rich in polyphenols. It is well known that plant polyphenols possess different biological activities and several functional foods contain this class of compounds. The polyphenol profile in an extract can be influenced by the plant part studied, the method of extraction and other parameters. This study performs a literature review using the words "coriander", "polyphenols" and "extraction" or "biological activity" in different databases such as PubMed, Google Scholar and Scopus. After that, we focus on the evidence of coriander polyphenols as protective agents against some inflammation-related diseases. Due to the bioactivities of coriander extract, this herb can be considered a valuable functional food against obesity, metabolic syndrome and diabetes.
C1 [Scandar, Samir; Zadra, Claudia; Marcotullio, Maria Carla] Univ Perugia, Dept Pharmaceut Sci, Via Giochetto Ed B, I-06122 Perugia, Italy.
C3 University of Perugia
RP Marcotullio, MC (corresponding author), Univ Perugia, Dept Pharmaceut Sci, Via Giochetto Ed B, I-06122 Perugia, Italy.
EM samir.scandar@studenti.unipg.it; claudia.zadra@unipg.it;
   mariacarla.marcotullio@unipg.it
RI Marcotullio, Maria Carla/A-2830-2011
OI Marcotullio, Maria Carla/0000-0001-9079-135X; Scandar,
   Samir/0009-0002-3942-1526
FU University of Perugia, Progetto Ricerca di Base 2017
FX This research was funded by the University of Perugia, Progetto Ricerca
   di Base 2017.
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TC 29
Z9 31
U1 4
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PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1420-3049
J9 MOLECULES
JI Molecules
PD MAY 19
PY 2023
VL 28
IS 10
AR 4187
DI 10.3390/molecules28104187
PG 12
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA H8DY4
UT WOS:000998215200001
PM 37241925
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Mellouk, Z
   Sener, A
   Yahia, DA
   Malaisse, WJ
AF Mellouk, Zoheir
   Sener, Abdullah
   Yahia, Dalila Ait
   Malaisse, Willy J.
TI The metabolic syndrome of fructose-fed rats: Effects of long-chain
   polyunsaturated ω3 and ω6 fatty acids. VII. Oxidative stress
SO MOLECULAR MEDICINE REPORTS
LA English
DT Article
DE metabolic syndrome; fructose-fed rats; long-chain polyunsaturated omega
   3 and omega 6 fatty acids
ID XYLENOL ORANGE; HYDROPEROXIDES
AB In the present study, the plasma concentration, and liver, heart, kidney, soleus muscle and visceral adipose tissue content of thiobarbituric acid reactive substrates (TBARS), carbonyl radicals, hydroperoxides and nitric oxide were measured in control rats exposed for 8 weeks to a diet containing 64% (w/w) starch and 5% sunflower oil and in animals fed a diet containing 64% D-fructose and 5% sunflower oil or 3.4% sunflower oil mixed with 1.6% safflower or salmon oil. Coherent measurements of the plasma concentrations or tissue contents of these metabolites revealed increases in TBARS, carbonyl radical and hydroperoxide levels and a decrease in nitric oxide levels in the 5% sunflower oil-fed rats. In the fructose-fed rats, the partial substitution of sunflower oil by either safflower or salmon oil minimized the changes. These findings provide further evidence in support of the favorable effects of the dietary supply of long-chain polyunsaturated omega 6 and omega 3 fatty acids upon the metabolic disturbances prevailing in the fructose-induced metabolic syndrome.
C1 [Sener, Abdullah; Malaisse, Willy J.] Univ Libre Brussels, Lab Expt Hormonol, B-1070 Brussels, Belgium.
   [Mellouk, Zoheir; Yahia, Dalila Ait] Es Senia Univ, Dept Biol, Es Senia 31100, Oran, Algeria.
C3 Universite Libre de Bruxelles; Universite d'Oran
RP Malaisse, WJ (corresponding author), Univ Libre Brussels, Lab Expt Hormonol, 808 Route Lennik, B-1070 Brussels, Belgium.
EM malaisse@ulb.ac.be
RI MELLOUK, Zoheir/AAF-7488-2019
CR Bostoglou NA, 1994, J AGR FOOD CHEM, V42, P1931
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NR 11
TC 4
Z9 5
U1 0
U2 10
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1791-2997
J9 MOL MED REP
JI Mol. Med. Rep.
PD DEC
PY 2012
VL 6
IS 6
BP 1409
EP 1412
DI 10.3892/mmr.2012.1093
PG 4
WC Oncology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Research & Experimental Medicine
GA 036HK
UT WOS:000311016800037
PM 23007226
OA Bronze
DA 2025-06-11
ER

PT J
AU Xiao, X
   Ge, HF
   Wang, YJ
   Wan, XC
   Li, DX
   Xie, ZW
AF Xiao, Xin
   Ge, Huifang
   Wang, Yijun
   Wan, Xiaochun
   Li, Daxiang
   Xie, Zhongwen
TI (-)-Gallocatechin Gallate Mitigates Metabolic Syndrome-Associated
   Diabetic Nephropathy in db/db Mice
SO FOODS
LA English
DT Article
DE metabolic syndrome; diabetic nephropathy; GCG; renal transcriptome
   analysis
ID GENE-EXPRESSION; KIDNEY-DISEASE; TUBULAR CELLS; RODENT MODELS; MURINE
   MODEL; PROGRESSION; INFLAMMATION; INHIBITION; INSULIN; LEPTIN
AB Metabolic syndrome (MetS) significantly predisposes individuals to diabetes and is a prognostic factor for the progression of diabetic nephropathy (DN). This study aimed to evaluate the efficacy of (-)-gallocatechin gallate (GCG) in alleviating signs of MetS-associated DN in db/db mice. We administered GCG and monitored its effects on several metabolic parameters, including food and water intake, urinary output, blood glucose levels, glucose and insulin homeostasis, lipid profiles, blood pressure, and renal function biomarkers. The main findings indicated that GCG intervention led to marked improvements in these metabolic indicators and renal function, signifying its potential in managing MetS and DN. Furthermore, transcriptome analysis revealed substantial modifications in gene expression, notably the downregulation of pro-inflammatory genes such as S100a8, S100a9, Cd44, Socs3, Mmp3, Mmp9, Nlrp3, IL-1 beta, Osm, Ptgs2, and Lcn2 and the upregulation of the anti-oxidative gene Gstm3. These genetic alterations suggest significant effects on pathways related to inflammation and oxidative stress. In conclusion, GCG demonstrates therapeutic efficacy for MetS-associated DN, mitigating metabolic disturbances and enhancing renal health by modulating inflammatory and oxidative responses.
C1 [Xiao, Xin; Ge, Huifang; Wang, Yijun; Wan, Xiaochun; Li, Daxiang; Xie, Zhongwen] Anhui Agr Univ, State Key Lab Tea Plant Biol & Utilizat, 130 Changjiang West Rd, Hefei 230036, Peoples R China.
   [Xiao, Xin; Ge, Huifang; Wang, Yijun; Wan, Xiaochun; Li, Daxiang; Xie, Zhongwen] Joint Res Ctr Food Nutr & Hlth IHM, Hefei 230036, Peoples R China.
C3 Anhui Agricultural University
RP Xie, ZW (corresponding author), Anhui Agr Univ, State Key Lab Tea Plant Biol & Utilizat, 130 Changjiang West Rd, Hefei 230036, Peoples R China.; Xie, ZW (corresponding author), Joint Res Ctr Food Nutr & Hlth IHM, Hefei 230036, Peoples R China.
EM 2021150@ahau.edu.cn; ghfjulia@ahau.edu.cn; yijun@ahau.edu.cn;
   xcwan@ahau.edu.cn; dxli@ahau.edu.cn; zhongwenxie@ahau.edu.cn
RI Wang, Yijun/GXW-1763-2022; li, daxiang/H-6815-2017; Xie,
   Zhongwen/I-7705-2019
OI Ge, Huifang/0000-0002-7321-3790; Xie, Zhongwen/0000-0002-3080-4881
FU National Natural Science Foundation of China
FX No Statement Available
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NR 60
TC 1
Z9 1
U1 7
U2 12
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2304-8158
J9 FOODS
JI Foods
PD JUN
PY 2024
VL 13
IS 11
AR 1755
DI 10.3390/foods13111755
PG 16
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA UG5A3
UT WOS:001246906200001
PM 38890983
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Kadar, NNMA
   Ahmad, F
   Teoh, SL
   Yahaya, MF
AF Muhammad Abdul Kadar, Nellysha Namela
   Ahmad, Fairus
   Teoh, Seong Lin
   Yahaya, Mohamad Fairuz
TI Caffeic Acid on Metabolic Syndrome: A Review
SO MOLECULES
LA English
DT Review
DE caffeic acid; metabolic syndrome; phenolic compound; obesity;
   dyslipidemia; hyperglycemia; hypertension
ID OXIDATIVE STRESS; PHENETHYL ESTER; ANTIOXIDANT PROPERTIES;
   PHENOLIC-ACIDS; INSULIN-RESISTANCE; CHLOROGENIC ACID; ELLAGIC ACID;
   IN-VITRO; PROPOLIS; MICE
AB Metabolic syndrome (MetS) is a constellation of risk factors that may lead to a more sinister disease. Raised blood pressure, dyslipidemia in the form of elevated triglycerides and lowered high-density lipoprotein cholesterol, raised fasting glucose, and central obesity are the risk factors that could lead to full-blown diabetes, heart disease, and many others. With increasing sedentary lifestyles, coupled with the current COVID-19 pandemic, the numbers of people affected with MetS will be expected to grow in the coming years. While keeping these factors checked with the polypharmacy available currently, there is no single strategy that can halt or minimize the effect of MetS to patients. This opens the door for a more natural way of controlling the disease. Caffeic acid (CA) is a phytonutrient belonging to the flavonoids that can be found in abundance in plants, fruits, and vegetables. CA possesses a wide range of beneficial properties from antioxidant, immunomodulatory, antimicrobial, neuroprotective, antianxiolytic, antiproliferative, and anti-inflammatory activities. This review discusses the current discovery of the effect of CA against MetS.
C1 [Muhammad Abdul Kadar, Nellysha Namela; Ahmad, Fairus; Teoh, Seong Lin; Yahaya, Mohamad Fairuz] Univ Kebangsaan Malaysia, Med Ctr, Fac Med, Dept Anat, Kuala Lumpur 56000, Malaysia.
   [Muhammad Abdul Kadar, Nellysha Namela] Univ Malaysia Sabah, Fac Med & Hlth Sci, Dept Biomed Sci & Therapeut, Kota Kinabalu 88400, Sabah, Malaysia.
C3 Universiti Kebangsaan Malaysia; Universiti Malaysia Sabah
RP Yahaya, MF (corresponding author), Univ Kebangsaan Malaysia, Med Ctr, Fac Med, Dept Anat, Kuala Lumpur 56000, Malaysia.
EM nellysha.namela@ums.edu.my; fairusahmad@ukm.edu.my;
   teohseonglin@ukm.edu.my; mfairuzy@ukm.edu.my
RI Yahaya, Mohamad/K-7614-2019; Teoh, Seong Lin/P-3950-2017
OI Yahaya, Mohamad Fairuz/0000-0001-7155-2636; Ahmad,
   Fairus/0000-0002-2452-6459; Teoh, Seong Lin/0000-0001-9733-8072
FU PPUKM Fundamental Grant [FF-2019-014]
FX This research was funded by PPUKM Fundamental Grant, grant number
   FF-2019-014.
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NR 94
TC 74
Z9 74
U1 2
U2 50
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1420-3049
J9 MOLECULES
JI Molecules
PD SEP
PY 2021
VL 26
IS 18
AR 5490
DI 10.3390/molecules26185490
PG 14
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA UZ1FR
UT WOS:000701958200001
PM 34576959
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Bhat, NR
AF Bhat, Narayan R.
TI Linking cardiometabolic disorders to sporadic Alzheimer's disease: a
   perspective on potential mechanisms and mediators
SO JOURNAL OF NEUROCHEMISTRY
LA English
DT Review
DE Alzheimer's disease; cholesterol; diabetes; inflammation; insulin
   resistance; metabolic syndrome
ID HIPPOCAMPAL SYNAPTIC PLASTICITY; CEREBRAL AMYLOID ANGIOPATHY; HIGH
   CHOLESTEROL DIET; INSULIN-RESISTANCE; APOLIPOPROTEIN-E; MOUSE MODEL;
   METABOLIC SYNDROME; OXIDATIVE STRESS; A-BETA; NEUROVASCULAR MECHANISMS
AB P>There is increasing evidence that the incidence of Alzheimer's disease (AD) is significantly influenced by cardiovascular risk factors in association with a cluster of metabolic diseases including diabetes and atherosclerosis. The shared risk is also reflected in the dietary and lifestyle links to both metabolic disorders and AD-type cognitive dysfunction. Recent studies with genetic and diet-induced animal models have begun to illuminate convergent mechanisms and mediators between these two categories of disease conditions with distinct tissue-specific pathologies. Although it is clear that peripheral inflammation and insulin resistance are central to the pathogenesis of the disorders of metabolic syndrome, it seems that the same mechanisms are also in play across the blood-brain barrier that lead to AD-like molecular and cognitive changes. This review highlights these convergent mechanisms and discusses the role of cerebrovascular dysfunction as a conduit to brain emergence of these pathogenic processes that might also represent future therapeutic targets in AD in common with metabolic disorders.
C1 Med Univ S Carolina, Dept Neurosci, Charleston, SC 29425 USA.
C3 Medical University of South Carolina
RP Bhat, NR (corresponding author), Med Univ S Carolina, Dept Neurosci, Charleston, SC 29425 USA.
EM bhatnr@musc.edu
FU NIH [R01NS051575, R21NS063183]
FX This work was supported by NIH grants, R01NS051575 and R21NS063183.
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NR 127
TC 56
Z9 64
U1 1
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-3042
EI 1471-4159
J9 J NEUROCHEM
JI J. Neurochem.
PD NOV
PY 2010
VL 115
IS 3
BP 551
EP 562
DI 10.1111/j.1471-4159.2010.06978.x
PG 12
WC Biochemistry & Molecular Biology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Neurosciences & Neurology
GA 664RE
UT WOS:000282979400001
PM 20807313
OA Bronze, Green Accepted
DA 2025-06-11
ER

PT J
AU Belenkaya, LV
   Darenskaya, MA
   Kolesnikov, SI
   Sholokhov, LF
   Danusevich, IN
   Lazareva, LM
   Nadeliaeva, IG
   Suturina, LV
   Kolesnikova, LI
AF Belenkaya, L. V.
   Darenskaya, M. A.
   Kolesnikov, S. I.
   Sholokhov, L. F.
   Danusevich, I. N.
   Lazareva, L. M.
   Nadeliaeva, Ia. G.
   Suturina, L. V.
   Kolesnikova, L. I.
TI Metabolic Syndrome in Reproductive Age Women of Various Ethnic Groups.
   Neuroendocrine Status and Lipid Peroxidation System
SO BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
LA English
DT Article
DE metabolic syndrome; ethnicity; neuroendocrine system; oxidative stress;
   women
ID PROLACTIN
AB We analyzed the state of neuroendocrine regulation and LPO-antioxidant defense systems in reproductive age women with metabolic syndrome (MetS), representatives of the Russian and Buryat ethnic groups. Compared to the corresponding control groups, women from the Russian ethnic group with MetS had elevated levels of thyroid-stimulating hormone and free androgen index (FAI) and reduced levels of sex hormone-binding globulin, while women from the Buryat ethnic group had increased levels of prolactin and FAI. Changes in the LPO system in women of the Russian ethnic group with MetS consisted in an increase in the levels of substrates with double bonds, TBA-reactive substances, and fat-soluble vitamins. Buryat women with MetS had a higher content of primary oxidation products and reduced levels of glutathione. The results of the study indicate a hyperandrogenic shift in the neuroendocrine regulation system, as well as compensatory influences from different parts of the antioxidant defense system in women of reproductive age with MetS, depending on their ethnicity. These findings indicate the need for assessing and monitoring the levels of these metabolites in women with MetS, considering their ethnicity.
C1 [Belenkaya, L. V.; Darenskaya, M. A.; Kolesnikov, S. I.; Sholokhov, L. F.; Danusevich, I. N.; Lazareva, L. M.; Nadeliaeva, Ia. G.; Suturina, L. V.; Kolesnikova, L. I.] Sci Ctr Family Hlth & Human Reprod Problems, Irkutsk, Russia.
C3 Irkutsk Science Centre of the Russian Academy of Sciences; Scientific
   Centre for Family Health & Human Reproduction Problems
RP Darenskaya, MA (corresponding author), Sci Ctr Family Hlth & Human Reprod Problems, Irkutsk, Russia.
EM marina_darenskaya@inbox.ru
RI Darenskaya, Marina/O-4490-2015; Kolesnikov, Sergey/M-4020-2016;
   Kolesnikova, Lubov/H-6424-2013; LAZAREVA, Lyudmila/K-4759-2018
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NR 20
TC 2
Z9 2
U1 0
U2 0
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0007-4888
EI 1573-8221
J9 B EXP BIOL MED+
JI Bull. Exp. Biol. Med.
PD OCT
PY 2024
VL 177
IS 6
BP 705
EP 710
DI 10.1007/s10517-024-06254-1
EA OCT 2024
PG 6
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA L7J5X
UT WOS:001338078100004
PM 39436574
DA 2025-06-11
ER

PT J
AU Della Vedova, MC
   Garcia, FMS
   Muñoz, MD
   Fornes, MW
   Mejiba, SEG
   Gómez, NN
   Ramirez, DC
AF Della Vedova, M. C.
   Soler Garcia, F. M.
   Munoz, M. D.
   Fornes, M. W.
   Gomez Mejiba, Sandra E.
   Gomez, N. N.
   Ramirez, Dario C.
TI Diet-Induced Pulmonary Inflammation and Incipient Fibrosis in Mice: a
   Possible Role of Neutrophilic Inflammation
SO INFLAMMATION
LA English
DT Article
DE diet; metabolic syndrome; neutrophilic inflammation; myeloperoxidase;
   incipient lung fibrosis
ID NITRIC-OXIDE; METABOLIC SYNDROME; OBESITY; LUNG; MYELOPEROXIDASE;
   ASSOCIATION; IMPAIRMENT; CYTOKINES; IMPACT; INDEX
AB Chicken fat and fructose are added into food-processing to reduce costs and enhance acceptability; however, these additives turn food into unhealthy and hypercaloric meals. Herein we have hypothesized that chronic feeding with chicken fat and fructose, together or by separate, can cause pulmonary redox and inflammatory changes. These changes are particularly related to neutrophils and myeloperoxidase, with consequent changes in the organ histophysiology. To test this hypothesis, we fed mice for 16 weeks with either control food (low-fat diet, LFD) or control food supplemented with 22% chicken fat and with or without 10% fructose in the drinking water. At the end of the feeding regimen, we measured redox and inflammatory changes in the lung with particular emphasis on neutrophil accumulation/activation and molecular-histological markers of fibrosis. Our results suggest that a diet supplemented with chicken fat and fructose causes additive effects on pulmonary oxidative stress, inflammation, and a pro-fibrotic status. Neutrophilic inflammation may play a critical role in pulmonary pathology associated with metabolic syndrome.
C1 [Della Vedova, M. C.; Munoz, M. D.; Gomez Mejiba, Sandra E.; Ramirez, Dario C.] Natl Univ San Luis, CONICET, Multidisciplinary Inst Biol Res San Luis, IMIBIO SL,Lab Expt & Translat Med, Suite 13X,First Floor,Chacabuco 917, RA-5700 San Luis, San Luis, Argentina.
   [Della Vedova, M. C.; Munoz, M. D.; Gomez Mejiba, Sandra E.] Natl Univ San Luis, CONICET, IMIBIO SL, Lab Expt Therapeut & Nutr, RA-5700 San Luis, San Luis, Argentina.
   [Soler Garcia, F. M.] Natl Univ San Luis, CONICET, IMIBIO SL, Lab Mol Biol, RA-5700 San Luis, Argentina.
   [Fornes, M. W.] Mendoza Natl Univ Cuyo, IHEM CCT, LIAM Androl Res Lab Mendoza, RA-5500 Mendoza, Mendoza, Argentina.
   [Gomez, N. N.] Natl Univ San Luis, CONICET, IMIBIO SL, Lab Anatomophophysiol, RA-5700 San Luis, San Luis, Argentina.
C3 Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET);
   Universidad Nacional de San Luis; Consejo Nacional de Investigaciones
   Cientificas y Tecnicas (CONICET); Universidad Nacional de San Luis;
   Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET);
   Universidad Nacional de San Luis; Consejo Nacional de Investigaciones
   Cientificas y Tecnicas (CONICET); Universidad Nacional de San Luis
RP Mejiba, SEG; Ramirez, DC (corresponding author), Natl Univ San Luis, CONICET, Multidisciplinary Inst Biol Res San Luis, IMIBIO SL,Lab Expt & Translat Med, Suite 13X,First Floor,Chacabuco 917, RA-5700 San Luis, San Luis, Argentina.
EM sandraegomezmejiba@yahoo.com; ramirezlabimibiosl@ymail.com
RI Gomez, Nidia/AAS-8766-2020; RAMIREZ, DARIO/K-3312-2013
OI RAMIREZ, DARIO/0000-0001-6725-3326; GOMEZ MEJIBA,
   SANDRA/0000-0002-8515-0483; Gomez, Nidia N./0000-0001-9549-1575
FU FONCYT, Argentina [PICT3369]; CONICET, Argentina [PIP916]; Universidad
   Nacional de San Luis, Argentina [PROICO2-3418, 10-0218]
FX Funding informationThis research was supported by the following grants:
   FONCYT, Argentina (PICT3369, to DCR and SEGM), CONICET, Argentina
   (PIP916, to DCR and SEGM), and Universidad Nacional de San Luis,
   Argentina (PROICO2-3418 to DCR; and PROICO, 10-0218 to SEGM).
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NR 50
TC 13
Z9 13
U1 0
U2 3
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0360-3997
EI 1573-2576
J9 INFLAMMATION
JI Inflammation
PD OCT
PY 2019
VL 42
IS 5
BP 1886
EP 1900
DI 10.1007/s10753-019-01051-9
PG 15
WC Cell Biology; Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Immunology
GA IU5XG
UT WOS:000483660100034
PM 31359324
DA 2025-06-11
ER

PT J
AU Jamal, A
   Brettle, H
   Jamil, DA
   Tran, V
   Diep, H
   Bobik, A
   van der Poel, C
   Vinh, A
   Drummond, GR
   Thomas, CJ
   Jelinic, M
   Al-Aubaidy, HA
AF Jamal, Abdulsatar
   Brettle, Holly
   Jamil, Dina A.
   Tran, Vivian
   Diep, Henry
   Bobik, Alexander
   van der Poel, Chris
   Vinh, Antony
   Drummond, Grant R.
   Thomas, Colleen J.
   Jelinic, Maria
   Al-Aubaidy, Hayder A.
TI Reduced Insulin Resistance and Oxidative Stress in a Mouse Model of
   Metabolic Syndrome following Twelve Weeks of Citrus Bioflavonoid
   Hesperidin Supplementation: A Dose-Response Study
SO BIOMOLECULES
LA English
DT Article
DE hesperidin; metabolic syndrome; HbA1c; insulin; 8-hydroxydeoxyguanosine
ID BLOOD-PRESSURE; NARINGIN; INDIVIDUALS; FLAVONOIDS; OBESE
AB Metabolic syndrome (MetS) is a cluster of metabolic abnormalities affecting similar to 25% of adults and is linked to chronic diseases such as cardiovascular disease, cancer, and neurodegenerative diseases. Oxidative stress and inflammation are key drivers of MetS. Hesperidin, a citrus bioflavonoid, has demonstrated antioxidant and anti-inflammatory properties; however, its effects on MetS are not fully established. We aimed to determine the optimal dose of hesperidin required to improve oxidative stress, systemic inflammation, and glycemic control in a novel mouse model of MetS. Male 5-week-old C57BL/6 mice were fed a high-fat, high-salt, high-sugar diet (HFSS; 42% kcal fat content in food and drinking water with 0.9% saline and 10% high fructose corn syrup) for 16 weeks. After 6 weeks of HFSS, mice were randomly allocated to either the placebo group or low- (70 mg/kg/day), mid- (140 mg/kg/day), or high-dose (280 mg/kg/day) hesperidin supplementation for 12 weeks. The HFSS diet induced significant metabolic disturbances. HFSS + placebo mice gained almost twice the weight of control mice (p < 0.0001). Fasting blood glucose (FBG) increased by 40% (p < 0.0001), plasma insulin by 100% (p < 0.05), and HOMA-IR by 150% (p < 0.0004), indicating insulin resistance. Hesperidin supplementation reduced plasma insulin by 40% at 140 mg/kg/day (p < 0.0001) and 50% at 280 mg/kg/day (p < 0.005). HOMA-IR decreased by 45% at both doses (p < 0.0001). Plasma hesperidin levels significantly increased in all hesperidin groups (p < 0.0001). Oxidative stress, measured by 8-OHdG, was increased by 40% in HFSS diet mice (p < 0.001) and reduced by 20% with all hesperidin doses (p < 0.005). In conclusion, hesperidin supplementation reduced insulin resistance and oxidative stress in HFSS-fed mice, demonstrating its dose-dependent therapeutic potential in MetS.
C1 [Jamal, Abdulsatar; Brettle, Holly; Jamil, Dina A.; Tran, Vivian; Diep, Henry; Bobik, Alexander; van der Poel, Chris; Vinh, Antony; Drummond, Grant R.; Thomas, Colleen J.; Jelinic, Maria; Al-Aubaidy, Hayder A.] Trobe Univ, Trobe Inst Mol Sci LIMS, Ctr Cardiovasc Biol & Dis Res, Bundoora, Vic 3086, Australia.
   [Jamal, Abdulsatar; Brettle, Holly; Jamil, Dina A.; Tran, Vivian; Diep, Henry; Bobik, Alexander; van der Poel, Chris; Vinh, Antony; Drummond, Grant R.; Thomas, Colleen J.; Jelinic, Maria; Al-Aubaidy, Hayder A.] Trobe Univ, Dept Microbiol Anat Physiol & Pharmacol MAPP, Bundoora, Vic 3086, Australia.
   [Jamil, Dina A.; Al-Aubaidy, Hayder A.] NewMed Educ Australia, Hamilton, Qld 4007, Australia.
   [Bobik, Alexander] Baker Heart & Diabet Res Inst, Melbourne, Vic 3004, Australia.
   [van der Poel, Chris] Australian Inst Musculoskeletal Sci, Melbourne, Vic 3021, Australia.
   [Thomas, Colleen J.] Univ Melbourne, Florey Inst Neurosci & Mental Hlth, Preclin Crit Care Unit, Parkville, Vic 3052, Australia.
C3 La Trobe University; La Trobe University; Baker Heart and Diabetes
   Institute; Australian Institute for Musculoskeletal Science; University
   of Melbourne; Florey Institute of Neuroscience & Mental Health
RP Jelinic, M; Al-Aubaidy, HA (corresponding author), Trobe Univ, Trobe Inst Mol Sci LIMS, Ctr Cardiovasc Biol & Dis Res, Bundoora, Vic 3086, Australia.; Jelinic, M; Al-Aubaidy, HA (corresponding author), Trobe Univ, Dept Microbiol Anat Physiol & Pharmacol MAPP, Bundoora, Vic 3086, Australia.; Al-Aubaidy, HA (corresponding author), NewMed Educ Australia, Hamilton, Qld 4007, Australia.
EM 20382699@students.latrobe.edu.au; h.brettle@latrobe.edu.au;
   dina.jamil@newmedschool.com.au; vivian.tran@latrobe.edu.au;
   h.diep@latrobe.edu.au; alex.bobik@baker.edu.au;
   c.vanderpoel@latrobe.edu.au; a.vinh@latrobe.edu.au;
   g.drummond@latrobe.edu.au; colleen.thomas@latrobe.edu.au;
   m.jelinic@latrobe.edu.au; h.alaubaidy@latrobe.edu.au
RI Vinh, Antony/JXO-0783-2024; Drummond, Grant/A-7427-2008; Al-Aubaidy,
   Hayder/J-7563-2014
OI Jamal, Abdulsatar/0009-0003-9728-3528; Jelinic,
   Maria/0000-0001-9773-4972; Tran, Vivian/0000-0001-5390-1919; Drummond,
   Grant/0000-0001-8556-9738; Al-Aubaidy, Hayder/0000-0001-9564-0120
FU La Trobe University internal start-up fund; Diabetes Australia Research
   Program General Grant; National Health and Medical Research Council
   (NHMRC); National Heart Foundation of Australia (NHF) [GNT1146314,
   101943]; Australian Research Training Scholarship
FX This research was funded by a La Trobe University internal start-up fund
   (H.A.A.-A.)and a Diabetes Australia Research Program General Grant (MJ,
   AV, GRD). MJ was supported by a joint National Health and Medical
   Research Council (NHMRC) and National Heart Foundation of Australia
   (NHF) Postdoctoral Fellowship (GNT1146314 and 101943). AJ and VT were
   supported byan Australian Research Training Scholarship.
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NR 61
TC 1
Z9 1
U1 6
U2 12
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2218-273X
J9 BIOMOLECULES
JI Biomolecules
PD JUN
PY 2024
VL 14
IS 6
AR 637
DI 10.3390/biom14060637
PG 19
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA WL2V5
UT WOS:001254967700001
PM 38927040
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Lévesque, K
   Bureau, S
   Moskowitz, DS
   Tardif, JC
   Lavoie, J
   Dupuis, G
   D'Antono, B
AF Levesque, Karine
   Bureau, Sebastien
   Moskowitz, D. S.
   Tardif, Jean-Claude
   Lavoie, Joel
   Dupuis, Gilles
   D'Antono, Bianca
TI Defensiveness and metabolic syndrome: Impact of sex and age
SO BIOLOGICAL PSYCHOLOGY
LA English
DT Article
DE Defensiveness; Metabolic syndrome; Blood pressure; Glucose level; Lipid
   profile; Sex differences
ID CORONARY HEART-DISEASE; AMBULATORY BLOOD-PRESSURE; COPING STYLES;
   CARDIOVASCULAR-RESPONSES; PHYSIOLOGICAL-RESPONSES; ADIPOSE-TISSUE;
   RISK-FACTOR; HOSTILITY; STRESS; HEALTH
AB The association between defensiveness and metabolic burden, as well as the moderating effects of sex and age were evaluated in 199 healthy working men (N = 81) and women (N = 118), aged 20-64 years (M = 41; S.D. = 11.45). Defensiveness (Marlowe-Crowne Social Desirability Scale) and parameters of metabolic syndrome (MS; waist circumference, HDL, triglycerides, glucose, 24 h ambulatory blood pressure) were obtained. In men, defensiveness was inversely related to MS burden (Beta = -.288; p = .001), as well as to individual measures of SBP, DBP, glucose and waist circumference (p < .05). In older women, high defensiveness was associated with a greater MS burden (p = .050) and glucose level (p = .005) while the reverse was true in younger women (p = .012). In conclusion, defensiveness was associated with a worse metabolic profile in older women but may be protective for men and younger women. Understanding the pathophysiological processes underlying these associations could elucidate sex and age differences and inform prevention efforts. (C) 2009 Elsevier B.V. All rights reserved.
C1 [Levesque, Karine; Bureau, Sebastien; Lavoie, Joel; Dupuis, Gilles; D'Antono, Bianca] Montreal Heart Inst, Res Ctr, Montreal, PQ H1T 1C8, Canada.
   [Levesque, Karine; Bureau, Sebastien; Tardif, Jean-Claude; Lavoie, Joel; Dupuis, Gilles; D'Antono, Bianca] Univ Montreal, Montreal, PQ H1T 1C8, Canada.
   [Tardif, Jean-Claude] Montreal Heart Inst, Dept Med, Montreal, PQ H1T 1C8, Canada.
   [Levesque, Karine; Bureau, Sebastien; Dupuis, Gilles; D'Antono, Bianca] Univ Quebec, Dept Psychol, Montreal, PQ H3C 3P8, Canada.
   [Moskowitz, D. S.] McGill Univ, Dept Psychol, Montreal, PQ H3A 1B1, Canada.
C3 Universite de Montreal; Universite de Montreal; Universite de Montreal;
   University of Quebec; University of Quebec Montreal; McGill University
RP D'Antono, B (corresponding author), Montreal Heart Inst, Res Ctr, 5000 Belanger St, Montreal, PQ H1T 1C8, Canada.
EM bianca.d.antono@umontreal.ca
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NR 58
TC 11
Z9 12
U1 0
U2 5
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0301-0511
EI 1873-6246
J9 BIOL PSYCHOL
JI Biol. Psychol.
PD MAR
PY 2009
VL 80
IS 3
BP 354
EP 360
DI 10.1016/j.biopsycho.2008.12.003
PG 7
WC Psychology, Biological; Behavioral Sciences; Psychology; Psychology,
   Experimental
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Behavioral Sciences
GA 426FF
UT WOS:000264692700013
PM 19150480
DA 2025-06-11
ER

PT J
AU Bjorklund, G
   Chirumbolo, S
AF Bjorklund, Geir
   Chirumbolo, Salvatore
TI Role of oxidative stress and antioxidants in daily nutrition and human
   health
SO NUTRITION
LA English
DT Review
DE Obesity; Metabolic syndrome; Oxidative stress; Reactive oxygen species;
   Phytochemicals; Antioxidant effect
ID TUMOR-NECROSIS-FACTOR; ENDOPLASMIC-RETICULUM STRESS; PU.1 TRANSCRIPTION
   FACTOR; GREEN TEA POLYPHENOLS; OXYGEN SPECIES ROS; ADIPOSE-TISSUE;
   METABOLIC SYNDROME; GUT MICROBIOTA; WHITE ADIPOSE; VITAMIN-A
AB Diet is a complex process that we are just beginning to fully understand. We need to develop a deeper comprehension of metabolism, energy balance, the molecular pathways involved in cellular stress response and survival, gut microflora genetics, enzymatic polymorphism within the human population, and the role of plant-derived polyphenols in this context. Metabolic syndrome, encompassing pathologies with a relatively high morbidity, such as type 2 diabetes, obesity, and cardiovascular disease, is a key concern in terms of how daily dietary habits should promote health and prevent metabolic impairments to prevent hospitalization and the need for health care. From a clinical point of view, very few papers deal with this concern; most of the evidence reported focuses instead on in vitro and animal models targeting the activity of phytochemicals contained in the daily diet A fundamental issue addressed by dietitians deals with the role exerted by redox-derived reactive species. Most plant polyphenols act as antioxidants, but recent evidence supports the idea that these compounds primarily activate a mild oxidative stress to elicit a positive, beneficial response from cells. How these compounds may act upon the detoxifying system exerting a scavenging role from reactive oxygen or nitrogen species is still a matter of debate; however, it can be argued that their role is even more complex than expected that they act as signaling molecules in the cross-talk mitochondria-endoplasmic reticulum and in enzymatic pathways involved in the energetic balance. In this relationship, a fundamental role is played by the brain-adipose tissue-gut axis. The aim of this review is to elucidate this topic, to present the state of the art with regard to the role of reactive species in cell signaling and the function of metabolism and survival, and to reappraise the role of plant-derived chemicals. (C) 2016 Elsevier Inc. All rights reserved.
C1 [Bjorklund, Geir] CONEM, Council Nutr & Environm Med, Mo I Rana, Norway.
   [Chirumbolo, Salvatore] Univ Verona, Dept Neurol & Movement Sci, Verona, Italy.
C3 University of Verona
RP Chirumbolo, S (corresponding author), Univ Verona, Dept Neurol & Movement Sci, Verona, Italy.
EM salvatore.chirumbolo@univr.it
RI Chirumbolo, Salvatore/AGF-1981-2022; Chirumbolo, Salvatore/L-6865-2016;
   Bjorklund, Geir/B-7319-2014
OI Chirumbolo, Salvatore/0000-0003-1789-8307; Bjorklund,
   Geir/0000-0003-2632-3935
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NR 190
TC 176
Z9 186
U1 2
U2 255
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0899-9007
EI 1873-1244
J9 NUTRITION
JI Nutrition
PD JAN
PY 2017
VL 33
BP 311
EP 321
DI 10.1016/j.nut.2016.07.018
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA EG3YQ
UT WOS:000390981000048
PM 27746034
DA 2025-06-11
ER

PT J
AU Christian, LM
   Wilson, SJ
   Madison, AA
   Prakash, RS
   Burd, CE
   Rosko, AE
   Kiecolt-Glaser, JK
AF Christian, Lisa M.
   Wilson, Stephanie J.
   Madison, Annelise A.
   Prakash, Ruchika S.
   Burd, Christin E.
   Rosko, Ashley E.
   Kiecolt-Glaser, Janice K.
TI Understanding the health effects of caregiving stress: New directions in
   molecular aging
SO AGEING RESEARCH REVIEWS
LA English
DT Review
ID EPSTEIN-BARR-VIRUS; CORONARY-HEART-DISEASE; LEUKOCYTE TELOMERE LENGTH;
   STEADY-STATE EXPRESSION; C-REACTIVE PROTEIN; OLDER-ADULTS; DEPRESSIVE
   SYMPTOMS; ALZHEIMERS-DISEASE; SPOUSAL CAREGIVERS; DNA METHYLATION
AB Dementia caregiving has been linked to multiple health risks, including infectious illness, depression, anxiety, immune dysregulation, weakened vaccine responses, slow wound healing, hypertension, cardiovascular disease, metabolic syndrome, diabetes, frailty, cognitive decline, and reduced structural and functional integrity of the brain. The sustained overproduction of proinflammatory cytokines is a key pathway behind many of these risks. However, contrasting findings suggest that some forms of caregiving may have beneficial effects, such as maintaining caregivers ' health and providing a sense of meaning and purpose which, in turn, may contribute to lower rates of functional decline and mortality. The current review synthesizes these disparate literatures, identifies methodological sources of discrepancy, and integrates caregiver research with work on aging biomarkers to propose a research agenda that traces the mechanistic pathways of caregivers ' health trajectories with a focus on the unique stressors facing spousal caregivers as compared to other informal caregivers. Combined with a focus on psychosocial moderators and mechanisms, studies using state-of-the-art molecular aging biomarkers such as telomere length, p(16INK4a), and epigenetic age could help to reconcile mixed literature on caregiving ' s sequelae by determining whether and under what conditions caregiving-related experiences contribute to faster aging, in part through inflammatory biology. The biomarkers predict morbidity and mortality, and each contributes non-redundant information about age-related molecular changes -together painting a more complete picture of biological aging. Indeed, assessing changes in these biopsychosocial mechanisms over time would help to clarify the dynamic relationships between caregiving experiences, psychological states, immune function, and aging.
C1 [Christian, Lisa M.; Kiecolt-Glaser, Janice K.] Ohio State Univ, Dept Psychiat & Behav Hlth, Wexner Med Ctr, Columbus, OH USA.
   [Christian, Lisa M.; Madison, Annelise A.; Kiecolt-Glaser, Janice K.] Ohio State Univ, Inst Behav Med Res, Wexner Med Ctr, Room 112,460 Med Ctr Dr, Columbus, OH 43210 USA.
   [Wilson, Stephanie J.] Southern Methodist Univ, Dept Psychol, University Pk, PA USA.
   [Madison, Annelise A.; Prakash, Ruchika S.] Ohio State Univ, Dept Psychol, Columbus, OH USA.
   [Prakash, Ruchika S.] Ohio State Univ, Ctr Cognit & Behav Brain Imaging, Columbus, OH USA.
   [Burd, Christin E.] Ohio State Univ, Dept Mol Genet, Columbus, OH USA.
   [Burd, Christin E.] Ohio State Univ, Dept Canc Biol, Columbus, OH USA.
   [Burd, Christin E.] Ohio State Univ, Dept Genet, Columbus, OH USA.
   [Rosko, Ashley E.] Ohio State Univ, Div Hematol, Columbus, OH USA.
C3 University System of Ohio; Ohio State University; University System of
   Ohio; Ohio State University; Southern Methodist University; University
   System of Ohio; Ohio State University; University System of Ohio; Ohio
   State University; University System of Ohio; Ohio State University;
   University System of Ohio; Ohio State University; University System of
   Ohio; Ohio State University; University System of Ohio; Ohio State
   University
RP Christian, LM (corresponding author), Ohio State Univ, Inst Behav Med Res, Wexner Med Ctr, Room 112,460 Med Ctr Dr, Columbus, OH 43210 USA.
EM Lisa.Christian@osumc.edu
RI Burd, Christin/AGV-6910-2022; Christian, Lisa/E-2892-2011
OI Burd, Christin/0000-0002-7919-3954
FU National Institute on Aging of the National Institutes of Health [R01
   AG069138, R00 AG056667]
FX Preparation of this manuscript was supported by the National Institute
   on Aging of the National Institutes of Health (R01 AG069138 LMC, JKG;
   R00 AG056667 SJW).
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NR 228
TC 13
Z9 15
U1 0
U2 5
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 1568-1637
EI 1872-9649
J9 AGEING RES REV
JI Ageing Res. Rev.
PD DEC
PY 2023
VL 92
DI 10.1016/j.arr.2023.102096
EA NOV 2023
PG 12
WC Cell Biology; Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Geriatrics & Gerontology
GA GB4L1
UT WOS:001150183400001
PM 37898293
OA Bronze
DA 2025-06-11
ER

PT J
AU Chandrasekhar, J
   Gill, A
   Mehran, R
AF Chandrasekhar, Jaya
   Gill, Amrita
   Mehran, Roxana
TI Acute myocardial infarction in young women: current perspectives
SO INTERNATIONAL JOURNAL OF WOMENS HEALTH
LA English
DT Review
DE acute myocardial infarction; young women; sex differences; women's
   health
ID CORONARY-ARTERY-DISEASE; ISCHEMIA SYNDROME EVALUATION; SYNDROME
   EVALUATION WISE; ESTROGEN PLUS PROGESTIN; SEX-RELATED DIFFERENCES; AMI
   PATIENTS VIRGO; GENDER-DIFFERENCES; ADVERSE OUTCOMES; MICROVASCULAR
   DYSFUNCTION; CARDIAC REHABILITATION
AB Acute myocardial infarction (AMI) is the leading cause of death in women worldwide. Every year, in the USA alone, more than 30,000 young women,55 years of age are hospitalized with AMI. In recent decades, the incidence of AMI is increasing in younger women in the context of increasing metabolic syndrome, diabetes mellitus, and non-traditional risk factors such as stress, anxiety, and depression. Although women are classically considered to present with atypical chest pain, several observational data confirm that men and women experience similar rates of chest pain, with some differences in intensity, duration, radiation, and the choice of descriptors. Women also experience more number of symptoms and more prodromal symptoms compared with men. Suboptimal awareness, sociocultural and financial reasons result in pre-hospital delays in women and lower rates of access to care with resulting under-treatment with guideline-directed therapies. Causes of AMI in young women include plaque-related MI, microvascular dysfunction or vasospasm, and spontaneous coronary artery dissection. Compared with men, women have greater in-hospital, early and late mortality, as a result of baseline comorbidities. Post-AMI women have lower referral to cardiac rehabilitation with more dropouts, lower levels of physical activity, and poorer improvements in health status compared with men, with higher inflammatory levels at 1-year from index presentation. Future strategies should focus on primary and secondary prevention, adherence, and post-AMI health-related quality of life. This review discusses the current evidence in the epidemiology, diagnosis, and treatment of AMI in young women.
C1 [Chandrasekhar, Jaya; Gill, Amrita; Mehran, Roxana] Icahn Sch Med Mt Sinai, Dept Cardiol, New York, NY 10029 USA.
   [Gill, Amrita] St Louis Univ, St Louis, MO 63103 USA.
C3 Icahn School of Medicine at Mount Sinai; Saint Louis University
RP Mehran, R (corresponding author), Icahn Sch Med Mt Sinai, Zena & Michael A Wiener Cardiovasc Inst, Dept Cardiol, One Gustave L Levy Pl,Box 1030, New York, NY 10029 USA.
EM roxana.mehran@mountsinai.org
RI Mehran, Roxana/ABF-4160-2021
FU Astra Zeneca; Medicines Co.; Bristol-Myers Squibb/Sanofi; Eli Lilly and
   Company/Daiichi Sankyo
FX The authors report no conflicts of interest in this work. Dr Mehran has
   received institutional grant support from Astra Zeneca, The Medicines
   Co., Bristol-Myers Squibb/Sanofi, and Eli Lilly and Company/Daiichi
   Sankyo. Dr Mehran is a consultant for AstraZeneca, Bayer, CSL Behring,
   Janssen Pharmaceuticals, Merck & Co, The Medicines Co., and Watermark
   Consulting. She serves on the advisory board of Abbott Laboratories,
   AstraZeneca, Boston Scientific, Covidien, Janssen Pharmaceuticals, Merck
   & Co., The Medicines Co., and Sanofi-Aventis and has equity in Claret
   Medical and Elixir Medical Corp. Dr Chandrasekhar and Ms Gill have no
   financial disclosures.
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NR 117
TC 55
Z9 60
U1 1
U2 12
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1179-1411
J9 INT J WOMENS HEALTH
JI Int. J. Womens Health
PY 2018
VL 10
BP 267
EP 284
DI 10.2147/IJWH.S107371
PG 18
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA GI8RK
UT WOS:000434792200002
PM 29922097
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Buffon, A
   Rigattieri, S
   Santini, SA
   Ramazzotti, V
   Crea, F
   Giardina, B
   Maseri, A
AF Buffon, A
   Rigattieri, S
   Santini, SA
   Ramazzotti, V
   Crea, F
   Giardina, B
   Maseri, A
TI Myocardial ischemia-reperfusion damage after pacing-induced tachycardia
   in patients with cardiac syndrome X
SO AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
LA English
DT Article
DE myocardial microcirculation; focal ischemia; free radicals; angina
ID NORMAL CORONARY-ARTERIES; LEFT-VENTRICULAR FUNCTION; ANGINA-PECTORIS;
   LIPID-PEROXIDATION; CHEST PAIN; DISEASE; ANGIOPLASTY; STRESS;
   ECHOCARDIOGRAPHY; ARTERIOGRAMS
AB The presence of myocardial ischemia in syndrome X (chest pain, "ischemia-like" electrocardiogram changes, and normal coronary angiograms) is uncertain possibly because, when focally distributed, it may not cause contractile dysfunction or lactate production. We measured lipid hydroperoxides (ROOHs) and conjugated dienes (CDs), two sensitive, independent markers of ischemia-reperfusion oxidative stress, in paired aortic and great cardiac vein blood samples before and after pacing-induced tachycardia in nine patients with syndrome X. Diagnostic ischemic S-T segment changes during pacing were followed by a consistent increase in ROOH and CD levels in the great cardiac vein (from 4.83 +/- 1.18 mu mol/l at baseline to 7.88 +/- 1.12 mmol/l and from 0.038 +/- 0.002 to 0.051 +/- 0.003 arbitrary units, respectively, P < 0.01). In controls, ROOH and CD levels did not change after pacing. The large postpacing cardiac release of lipid peroxidation products, consistently observed in all patients and similar to that previously observed after ischemia caused by percutaneous transluminal coronary angioplasty, is consistent with an ischemic origin of syndrome X.
C1 Univ Cattolica Sacro Cuore, Inst Cardiol, I-00168 Rome, Italy.
   Univ Cattolica Sacro Cuore, Inst Biochem, I-00168 Rome, Italy.
   Univ Cattolica Sacro Cuore, Inst Chem & Clin Chem, I-00168 Rome, Italy.
C3 Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli;
   Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli;
   Catholic University of the Sacred Heart; IRCCS Policlinico Gemelli
RP Univ Cattolica Sacro Cuore, Inst Cardiol, Largo Gemelli 8, I-00168 Rome, Italy.
EM abuffon@mail.omnitel.it
RI Rigattieri, Stefano/AAL-9063-2020
OI Buffon, Antonino/0000-0001-8144-6597; Rigattieri,
   Stefano/0000-0001-5116-2737
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NR 44
TC 52
Z9 54
U1 0
U2 2
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0363-6135
EI 1522-1539
J9 AM J PHYSIOL-HEART C
JI Am. J. Physiol.-Heart Circul. Physiol.
PD DEC
PY 2000
VL 279
IS 6
BP H2627
EP H2633
DI 10.1152/ajpheart.2000.279.6.H2627
PG 7
WC Cardiac & Cardiovascular Systems; Physiology; Peripheral Vascular
   Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Physiology
GA 375NZ
UT WOS:000165409300009
PM 11087214
DA 2025-06-11
ER

PT J
AU Jing, XX
   Zhou, JX
   Zhang, NH
   Zhao, L
   Wang, SR
   Zhang, LB
   Zhou, F
AF Jing, Xiaoxuan
   Zhou, Jingxuan
   Zhang, Nanhai
   Zhao, Liang
   Wang, Shiran
   Zhang, Liebing
   Zhou, Feng
TI A Review of the Effects of Puerarin on Glucose and Lipid Metabolism in
   Metabolic Syndrome: Mechanisms and Opportunities
SO FOODS
LA English
DT Review
DE puerarin; sugar metabolism; lipid metabolism; metabolic syndrome;
   bioavailability
ID INSULIN-RESISTANCE; TRANSCRIPTIONAL REGULATION; ORAL BIOAVAILABILITY;
   OXIDATIVE STRESS; HEPATIC GLUCOSE; DIABETIC-RATS; EXPRESSION;
   HOMEOSTASIS; ADIPOCYTE; SYSTEM
AB Chronic diseases, including metabolic syndrome related to sugar and lipid metabolic disorders, are the leading causes of premature death around the world. Novel treatment strategies without undesirable effects are urgently needed. As a natural functional ingredient, puerarin is a promising alternative for the treatment of sugar and lipid metabolic disorders. However, the applications of puerarin are limited due to its poor solubility and short half-life. Various drug delivery systems have been investigated to improve the bioavailability of puerarin. This review summarizes the mechanisms involved in the beneficial action of puerarin: suppressing the release of glucose and FFA; regulating the transport of glucose and fatty acids; acting on the PI3K-Akt and AMPK signaling pathways to decrease the synthesis of glucose and fatty acids; acting on the PPAR signaling pathway to promote beta-oxidation; and improving insulin secretion and sensitivity. In addition, the preparation technologies used to improve the bioavailability of puerarin are also summarized in this review, in the hope of helping to promote the application of puerarin.
C1 [Jing, Xiaoxuan; Zhou, Jingxuan; Zhang, Nanhai; Wang, Shiran; Zhang, Liebing; Zhou, Feng] China Agr Univ, Coll Food Sci & Nutr Engn, Beijing Key Lab Funct Food Plant Resources, Beijing 100083, Peoples R China.
   [Zhao, Liang] Beijing Technol & Business Univ BTBU, Beijing Engn & Technol Res Ctr Food Addit, Beijing 100048, Peoples R China.
C3 China Agricultural University; Beijing Technology & Business University
RP Zhang, LB; Zhou, F (corresponding author), China Agr Univ, Coll Food Sci & Nutr Engn, Beijing Key Lab Funct Food Plant Resources, Beijing 100083, Peoples R China.
EM lbzhang@cau.edu.cn; zf@cau.edu.cn
RI jing, xiaoxuan/JFA-5074-2023
OI Zhao, Liang/0000-0003-2542-9279; Zhang, Nanhai/0000-0002-4733-277X;
   Zhou, Feng/0000-0003-0665-8076
FU National Dairy Industry and Technology System of China [CARS- 36];
   Analysis of Active Components and Function Evaluation of Danxi Hongqu
   Rice Wines [202205410610167]; National Dairy Industry and Technology
   System of China
FX This study was funded by Analysis of Active Components and Function
   Evaluation of Danxi Hongqu Rice Wines (202205410610167) and the National
   Dairy Industry and Technology System of China (Grant no. CARS- 36). This
   research was funded by the National Dairy Industry and Technology System
   of China, grant number CARS- 36. The APC was funded by Analysis of
   Active Components and Function Evaluation of Danxi Hongqu Rice Wines
   (202205410610167).
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NR 84
TC 6
Z9 8
U1 8
U2 48
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2304-8158
J9 FOODS
JI Foods
PD DEC
PY 2022
VL 11
IS 23
AR 3941
DI 10.3390/foods11233941
PG 17
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA 6Y6XT
UT WOS:000897236400001
PM 36496749
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Pavlov, VA
AF Pavlov, Valentin A.
TI The evolving obesity challenge: targeting the vagus nerve and the
   inflammatory reflex in the response
SO PHARMACOLOGY & THERAPEUTICS
LA English
DT Review
DE Obesity; Metabolic syndrome; COVID-19; Inflammation; The inflammatory
   reflex; Bioelectronic medicine
ID METABOLIC SYNDROME; CARDIOVASCULAR-DISEASE; ULTRASOUND STIMULATION;
   INSULIN-RESISTANCE; DIABETES-MELLITUS; OXIDATIVE STRESS; SENSORY
   NEURONS; CYTOKINE STORM; ADIPOSE-TISSUE; RISK-FACTORS
AB Obesity and the metabolic syndrome (MetS), which have reached pandemic proportions significantly increase the risk for type 2 diabetes, cardiovascular disease, and other serious conditions. Recent data with COVID-19 patients indicate that obesity also is a significant risk factor for this novel viral disease and poor outcome of associated critical illness. These findings considerably change the view of obesity as a driver of serious, but slowly progressing chronic diseases, and emphasize the urgency to explore new therapeutic approaches. Inflammation is a recognized driver of metabolic derangements in obesity and MetS, and a core feature of COVID-19 pathobiology. Recent advances in our understanding of inflammatory regulation have highlighted the role of the nervous system and the vagus nerve-based inflammatory reflex. Current bioelectronic and pharmacological therapeutic explorations centered on the inflammatory reflex offer new approaches for conditions characterized by immune and metabolic dysregulation and for ameliorating the escalating burden of obesity, MetS, and COVID-19.
   (c) 2020 Elsevier Inc. All rights reserved.
C1 [Pavlov, Valentin A.] Northwell Hlth, Feinstein Inst Med Res, Inst Bioelect Med, Manhasset, NY 11030 USA.
   [Pavlov, Valentin A.] Donald & Barbara Zucker Sch Med Hofstra Northwell, Hempstead, NY 11549 USA.
C3 Northwell Health; Northwell Health
RP Pavlov, VA (corresponding author), Northwell Hlth, Feinstein Inst Med Res, 350 Community Dr, Manhasset, NY 11030 USA.
EM vpavlov@northwell.edu
OI Pavlov, Valentin/0000-0002-1994-2853
FU National Institutes of Health (NIH) , NIGMS [R01GM128008, R01GM121102]
FX This work was supported by the National Institutes of Health (NIH) ,
   NIGMS Grants: R01GM128008 and R01GM121102 to V.A.P.
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NR 240
TC 23
Z9 24
U1 1
U2 12
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0163-7258
EI 1879-016X
J9 PHARMACOL THERAPEUT
JI Pharmacol. Ther.
PD JUN
PY 2021
VL 222
AR 107794
DI 10.1016/j.pharmthera.2020.107794
PG 13
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA SD1QY
UT WOS:000651143100003
PM 33310156
OA Green Published
DA 2025-06-11
ER

PT J
AU Ferreira, I
   Beijers, HJ
   Schouten, F
   Smulders, YM
   Twisk, JW
   Stehouwer, CD
AF Ferreira, Isabel
   Beijers, Hanneke J.
   Schouten, Fleur
   Smulders, Yvo M.
   Twisk, Jos W.
   Stehouwer, Coen D.
TI Clustering of Metabolic Syndrome Traits Is Associated With Maladaptive
   Carotid Remodeling and Stiffening A 6-Year Longitudinal Study
SO HYPERTENSION
LA English
DT Article
DE metabolic syndrome; carotid remodeling; longitudinal study; young adults
ID INTIMA-MEDIA THICKNESS; CARDIOVASCULAR RISK; ARTERIAL STIFFNESS;
   AMSTERDAM GROWTH; PULSE PRESSURE; HEALTH; DETERMINANTS; EVENTS; STRESS;
   ADULTS
AB Maladaptive arterial remodeling may constitute a mechanism underlying the risk of stroke in individuals with the metabolic syndrome (MetS), but evidence supporting this contention derives from cross-sectional studies only. We, therefore, investigated, in apparently healthy adults, whether changes in MetS status between the ages of 36 and 42 years (never [n = 207, reference group], incident [n = 31], recovery [n = 23], and persistent [n = 32]) were associated with changes in carotid interadventitial diameter, lumen diameter, intima-media thickness, circumferential wall tension and stress, and Young's elastic modulus. All data analyses were adjusted for sex, height, and (changes in) age, lifestyle variables, low-density lipoprotein cholesterol, and use of antihypertensive medication. At baseline and as compared with the reference group, individuals with persistent MetS had significantly higher interadventitial diameter, circumferential wall tension, circumferential wall stress, and Young's elastic modulus but not intima-media thickness. In the course of follow-up, these individuals (versus reference group) displayed significantly steeper increases in intima-media thickness (0.011 versus 0.005 mm/y), which were accompanied by significantly steeper increases in interadventitial diameter (0.077 versus 0.032 mm/y) and lumen diameter (0.055 versus 0.023 mm/y) but not circumferential wall stress, which decreased (-0.34 versus 0.12 kPa/y). These findings suggest that increases in intima-media thickness in young adults with the MetS may primarily reflect an adaptive mechanism that attempts to restore local hemodynamic conditions to an equilibrium rather than atherosclerosis, per se. However, carotid adaptations did not restore circumferential wall stress to levels comparable with those of the reference group, and, therefore, outward remodeling was maladaptive. Importantly, individuals who recovered from the MetS restored carotid properties to levels comparable to the reference group, emphasizing the potential for reversibility. (Hypertension. 2012; 60: 542-549.). Online Data Supplement
C1 [Ferreira, Isabel] Maastricht Univ, Med Ctr, Dept Clin Epidemiol & Med Technol Assessment, NL-6202 AZ Maastricht, Netherlands.
   [Ferreira, Isabel; Stehouwer, Coen D.] Maastricht Univ, Med Ctr, Dept Internal Med, NL-6202 AZ Maastricht, Netherlands.
   [Ferreira, Isabel; Stehouwer, Coen D.] Maastricht Univ, Med Ctr, Sch Cardiovasc Dis, NL-6202 AZ Maastricht, Netherlands.
   [Beijers, Hanneke J.] Catharina Hosp, Dept Med, Eindhoven, Netherlands.
   [Schouten, Fleur; Twisk, Jos W.] Vrije Univ Amsterdam, Fac Earth & Life Sci, Dept Hlth Sci, Amsterdam, Netherlands.
   [Schouten, Fleur; Twisk, Jos W.] Vrije Univ Amsterdam, Fac Earth & Life Sci, EMGO Inst Hlth & Care Res, Amsterdam, Netherlands.
   [Schouten, Fleur; Smulders, Yvo M.] Vrije Univ Amsterdam Med Ctr, Inst Cardiovasc Res, Amsterdam, Netherlands.
   [Twisk, Jos W.] Vrije Univ Amsterdam Med Ctr, Dept Clin Epidemiol & Biostat, Amsterdam, Netherlands.
C3 Maastricht University; Maastricht University; Maastricht University;
   Catharina Hospital; Vrije Universiteit Amsterdam; Vrije Universiteit
   Amsterdam; Vrije Universiteit Amsterdam; VU UNIVERSITY MEDICAL CENTER;
   Vrije Universiteit Amsterdam; VU UNIVERSITY MEDICAL CENTER
RP Ferreira, I (corresponding author), Maastricht Univ, Med Ctr, Dept Clin Epidemiol & Med Technol Assessment, P Debyelaan 25,POB 5800, NL-6202 AZ Maastricht, Netherlands.
EM i.ferreira@maastrichtuniversity.nl
RI Stehouwer, Coen/AAB-3435-2021; Smulders, YM/AAG-7506-2021; Ferreira de
   Sousa, Maria Isabel/B-6033-2008
OI Ferreira de Sousa, Maria Isabel/0000-0003-1434-0607; Stehouwer,
   Coen/0000-0001-8752-3223
FU Netherlands Heart Foundation [2006T050]
FX A postdoctoral research grant (No. 2006T050) from the Netherlands Heart
   Foundation was obtained by I.F. to conduct the research described in
   this article.
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NR 31
TC 32
Z9 37
U1 0
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0194-911X
EI 1524-4563
J9 HYPERTENSION
JI Hypertension
PD AUG
PY 2012
VL 60
IS 2
BP 542
EP +
DI 10.1161/HYPERTENSIONAHA.112.194738
PG 17
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 975ZS
UT WOS:000306550900120
PM 22733470
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Dagdeviren, H
   Cengiz, H
AF Dagdeviren, Hediye
   Cengiz, Huseyin
TI Association between Metabolic Syndrome and Serum Nerve Growth Factor
   Levels in Women with Overactive Bladder
SO GYNECOLOGIC AND OBSTETRIC INVESTIGATION
LA English
DT Article
DE Metabolic syndrome; Nerve growth; Overactive bladder; Sympathetic
   overactivity
ID URINARY-TRACT SYMPTOMS; PREVALENCE; HUMANS; LIFE
AB Objective: This study aimed to determine the association between overactive bladder (OAB), metabolic syndrome (MetS) and serum nerve growth factors (NGF). Study Design: Serum samples from a group of 90 women that included patients with OAB (group 1), patients with both OAB and MetS (group 2) and healthy women without OAB and MetS (group 3). Each group included 30 patients. Serum levels of NGF were compared among the groups. Results: When the groups were compared with respect to NGF levels, group 2 was found to have significantly higher NGF levels (p = 0.001). A NGF threshold of >380 ng/mL had a sensitivity of 81.7% and a specificity of 100% to discriminate between groups 2 and 3. Conclusion: Our findings support the theory that possible sympathetic overactivity, proinflammatory status, oxidative stress and other pathological conditions associated with MetS and potentially involved in the development of OAB lead to increased serum NGF levels. These findings may help to shed light on the complicated pathogenesis of OAB. (C) 2017 S. Karger AG, Basel
C1 [Dagdeviren, Hediye; Cengiz, Huseyin] Bakirkoy Dr Sadi Konuk Teaching & Res Hosp, Dept Obstet & Gynaecol, Istanbul, Turkey.
C3 Bakirkoy Dr. Sadi Konuk Research & Training Hospital
RP Dagdeviren, H (corresponding author), Bakirkoy Dr Sadi Konuk Teaching & Res Hosp, Tevfik Saglam St 11, Istanbul, Turkey.
EM hediyedagdeviren@gmail.com
RI Cengiz, Hüseyin/AAF-4187-2019
OI dagdeviren, Hediye/0000-0002-9384-4514
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NR 31
TC 9
Z9 11
U1 0
U2 2
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0378-7346
EI 1423-002X
J9 GYNECOL OBSTET INVES
JI Gynecol.Obstet.Invest.
PY 2018
VL 83
IS 2
BP 140
EP 144
DI 10.1159/000477170
PG 5
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA GB1MY
UT WOS:000428816100005
PM 28637031
DA 2025-06-11
ER

PT J
AU Baldessarini, RJ
   Vázquez, GH
   Tondo, L
AF Baldessarini, Ross J.
   Vazquez, Gustavo H.
   Tondo, Leonardo
TI Bipolar depression: a major unsolved challenge
SO INTERNATIONAL JOURNAL OF BIPOLAR DISORDERS
LA English
DT Review
DE Bipolar disorder; Depression; Disability; Morbidity; Mortality; Suicide;
   Treatment
ID TERM ANTIDEPRESSANT TREATMENT; RANDOMIZED CLINICAL-TRIAL; VAGUS
   NERVE-STIMULATION; SUICIDE RISK; DOUBLE-BLIND; LITHIUM TREATMENT; I
   DISORDER; UNIPOLAR DEPRESSION; SUBSTANCE USE; ALL-CAUSE
AB Depression in bipolar disorder (BD) patients presents major clinical challenges. As the predominant psychopathology even in treated BD, depression is associated not only with excess morbidity, but also mortality from co-occurring general-medical disorders and high suicide risk. In BD, risks for medical disorders including diabetes or metabolic syndrome, and cardiovascular disorders, and associated mortality rates are several-times above those for the general population or with other psychiatric disorders. The SMR for suicide with BD reaches 20-times above general-population rates, and exceeds rates with other major psychiatric disorders. In BD, suicide is strongly associated with mixed (agitated-dysphoric) and depressive phases, time depressed, and hospitalization. Lithium may reduce suicide risk in BD; clozapine and ketamine require further testing. Treatment of bipolar depression is far less well investigated than unipolar depression, particularly for long-term prophylaxis. Short-term efficacy of antidepressants for bipolar depression remains controversial and they risk clinical worsening, especially in mixed states and with rapid-cycling. Evidence of efficacy of lithium and anticonvulsants for bipolar depression is very limited; lamotrigine has long-term benefit, but valproate and carbamazepine are inadequately tested and carry high teratogenic risks. Evidence is emerging of short-term efficacy of several modern antipsychotics (including cariprazine, lurasidone, olanzapine-fluoxetine, and quetiapine) for bipolar depression, including with mixed features, though they risk adverse metabolic and neurological effects.
C1 [Baldessarini, Ross J.; Tondo, Leonardo] Harvard Med Sch, Dept Psychiat, Boston, MA 02115 USA.
   [Baldessarini, Ross J.; Vazquez, Gustavo H.; Tondo, Leonardo] McLean Hosp, Int Consortium Bipolar & Psychot Disorders Res, 115 Mill St, Belmont, MA 02178 USA.
   [Vazquez, Gustavo H.] Queens Univ, Dept Psychiat, Sch Med, Kingston, ON, Canada.
   [Tondo, Leonardo] Lucio Bini Mood Disorder Ctr, Cagliari, Sardinia, Italy.
C3 Harvard University; Harvard Medical School; Harvard University; Harvard
   University Medical Affiliates; McLean Hospital; Queens University -
   Canada
RP Baldessarini, RJ (corresponding author), Harvard Med Sch, Dept Psychiat, Boston, MA 02115 USA.; Baldessarini, RJ (corresponding author), McLean Hosp, Int Consortium Bipolar & Psychot Disorders Res, 115 Mill St, Belmont, MA 02178 USA.
EM rbaldessarini@mclean.harvard.edu
RI Baldessarini, Ross/ADO-8296-2022; Vazquez, Gustavo/GOV-5850-2022
OI Baldessarini, Ross/0000-0001-9718-8211; Vazquez,
   Gustavo/0000-0002-2918-3336
FU Bruce J. Anderson Foundation; McLean Private Donors Psychiatric Research
   Fund; Aretaeus Foundation of Rome
FX Supported by a grant from the Bruce J. Anderson Foundation and the
   McLean Private Donors Psychiatric Research Fund (to RJB), and by a grant
   from the Aretaeus Foundation of Rome (to LT).
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NR 188
TC 136
Z9 139
U1 3
U2 51
PU SPRINGEROPEN
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 2194-7511
J9 INT J BIPOLAR DISORD
JI INT. J. BIBPOLAR DISORD.
PD JAN 6
PY 2020
VL 8
IS 1
AR 1
DI 10.1186/s40345-019-0160-1
PG 13
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA KJ0BA
UT WOS:000511722100001
PM 31903509
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Harding, JD
AF Harding, John D.
TI Nonhuman Primates and Translational Research: Progress, Opportunities,
   and Challenges
SO ILAR JOURNAL
LA English
DT Article
DE animal model; animal rights; chimpanzee; genomics; macaque; monkey;
   nonhuman primate; translational research
ID RHESUS MACAQUE; REGULATIONS; MODELS; LAWS; STANDARDS; ANIMALS;
   GENERATION; GENETICS; GENOMICS; POLICIES
AB Nonhuman primates (NHPs) are the closest animal models to humans regarding genetics, physiology and behavior. Therefore, NHPs are usually a critical component in translational research projects aimed at developing therapeutics, vaccines, devices or other interventions aimed at preventing, curing or ameliorating human disease. NHPs are often used in conjunction with other animal models, such as rodents, and results obtained using NHPs must often be used as the final criterion for establishing the potential efficacy of a pharmaceutical or vaccine before transition to human clinical trails. In some cases, NHPs may be the only relevant animal models for a particlular translational study. This issue of the ILAR journal brings together, in one place, articles that discuss the use of NHP models for studying human diseases that are highly prevalent and that cause extraordinary human suffering and financial and social burdens. Topics covered in detail include: tuberculosis; viral hepatitis; HIV/AIDS; neurodegenerative disorders; Substance abuse disorders; vision and prevention of blindness; disorder associated with psychosocial processes, such as anxiety, depression and loneliness; cardiovascular disease; metabolic disease, such as obesity and metabolic syndrome; respiratory disease; and female reproduction, prenatal development and women's health. Proper husbandry of NHPs that reduces stress and maintains animal health is critical for the development of NHP models. This issue of the journal includes a review of procedures for environmental enrichment, which helps assure animal health and wellbeing. Taken together, these articles provide detailed reviews of the use of NHP models for translational investigations and discuss successes, limitations, challenges and opportunities associated with this research.
C1 [Harding, John D.] NIH, Bldg 10, Bethesda, MD 20892 USA.
   [Harding, John D.] NIH, Grants Funding, US Natl Primate Res Ctr, Bldg 10, Bethesda, MD 20892 USA.
C3 National Institutes of Health (NIH) - USA; National Institutes of Health
   (NIH) - USA
RP Harding, JD (corresponding author), NIH, Bldg 10, Bethesda, MD 20892 USA.
EM hardingarts@gmail.com
FU NIH HHS [P40 OD012217] Funding Source: Medline
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PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 1084-2020
EI 1930-6180
J9 ILAR J
JI ILAR J.
PY 2017
VL 58
IS 2
BP 141
EP 150
DI 10.1093/ilar/ilx033
PG 10
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA FT1CW
UT WOS:000422873000001
PM 29253273
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Coronati, M
   Baratta, F
   Pastori, D
   Ferro, D
   Angelico, F
   Del Ben, M
AF Coronati, Mattia
   Baratta, Francesco
   Pastori, Daniele
   Ferro, Domenico
   Angelico, Francesco
   Del Ben, Maria
TI Added Fructose in Non-Alcoholic Fatty Liver Disease and in Metabolic
   Syndrome: A Narrative Review
SO NUTRIENTS
LA English
DT Article
DE NAFLD; metabolic syndrome; fructose; HFCS
ID SUGAR-SWEETENED BEVERAGES; HEALTHY-YOUNG MEN; CORN SYRUP;
   INSULIN-RESISTANCE; MEDITERRANEAN DIET; MODERATE AMOUNTS; CONSUMPTION;
   WEIGHT; SUCROSE; ACID
AB Non-alcoholic fatty liver disease (NAFLD) represents the most common chronic liver disease and it is considered the hepatic manifestation of metabolic syndrome (MetS). Diet represents the key element in NAFLD and MetS treatment, but some nutrients could play a role in their pathophysiology. Among these, fructose added to foods via high fructose corn syrup (HFCS) and sucrose might participate in NAFLD and MetS onset and progression. Fructose induces de novo lipogenesis (DNL), endoplasmic reticulum stress and liver inflammation, promoting insulin resistance and dyslipidemia. Fructose also reduces fatty acids oxidation through the overproduction of malonyl CoA, favoring steatosis. Furthermore, recent studies suggest changes in intestinal permeability associated with fructose consumption that contribute to the risk of NAFLD and MetS. Finally, alterations in the hunger-satiety mechanism and in the synthesis of uric acid link the fructose intake to weight gain and hypertension, respectively. However, further studies are needed to better evaluate the causal relationship between fructose and metabolic diseases and to develop new therapeutic and preventive strategies against NAFLD and MetS.
C1 [Coronati, Mattia; Baratta, Francesco; Pastori, Daniele; Ferro, Domenico; Del Ben, Maria] Sapienza Univ Rome, Dept Clin Internal Anesthesiol & Cardiovasc Sci, Clin Med 1, I-00161 Rome, Italy.
   [Angelico, Francesco] Sapienza Univ Rome, Dept Publ Hlth & Infect Dis, I-00161 Rome, Italy.
C3 Sapienza University Rome; Sapienza University Rome
RP Baratta, F (corresponding author), Sapienza Univ Rome, Dept Clin Internal Anesthesiol & Cardiovasc Sci, Clin Med 1, I-00161 Rome, Italy.
EM coronati.1765853@studenti.uniroma1.it; francesco.baratta@uniroma1.it;
   daniele.pastori@uniroma1.it; domenico.ferro@uniroma1.it;
   francesco.angelico@uniroma1.it; maria.delben@uniroma1.it
RI Del Ben, Maria/AAE-7603-2020; Angelico, Francesco/AAB-6585-2020;
   pastori, daniele/J-7087-2016
OI DEL BEN, MARIA/0000-0003-1199-8454; pastori,
   daniele/0000-0001-6357-5213; Coronati, Mattia/0000-0003-0052-1378;
   Baratta, Francesco/0000-0003-1708-272X
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NR 77
TC 37
Z9 39
U1 3
U2 22
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD MAR
PY 2022
VL 14
IS 6
AR 1127
DI 10.3390/nu14061127
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 0B4RD
UT WOS:000774623000001
PM 35334784
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Chaput, JP
   Stranges, S
AF Chaput, Jean-Philippe
   Stranges, Saverio
TI Sleep: The silent hero in cardiometabolic health
SO NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
LA English
DT Article
DE Sleep health; Cardiovascular disease; Hypertension; Obesity; Insulin
   resistance; Type 2 diabetes
ID MIDLIFE WOMEN; INSUFFICIENT SLEEP; PHYSICAL-ACTIVITY; OLDER-ADULTS;
   DURATION; ASSOCIATIONS; QUALITY; HYPERTENSION; SYMPTOMS; INSOMNIA
AB The essential role of sleep in overall health is increasingly recognized, yet it remains underemphasized in both clinical and public health contexts. Despite extensive research linking poor sleep health to chronic conditions such as cardiovascular disease, type 2 diabetes, and cognitive decline, sleep health is not routinely assessed or integrated into standard care practices. Sleep problems, including insomnia, sleep apnea, and poor sleep quality, are prevalent globally, affecting over 30 % of the population and contributing to significant public health burdens like cardiometabolic disease, mental health disorders and multimorbidity. The economic implications are substantial, with insufficient sleep imposing significant societal and financial costs worldwide. Recognizing this, recent initiatives like the American Heart Association's inclusion of sleep in the Life's Essential 8 framework highlight the importance of sleep in cardiometabolic health. Integrating sleep into clinical and public health strategies is crucial, due to the wide-ranging impact of sleep on cardiometabolic health. Social, environmental, and demographic factors also play significant roles in sleep health, with lower socioeconomic groups and women often experiencing poorer sleep, further exacerbating health disparities. Adopting a life course approach and promoting healthy sleep behaviors early in life are essential for mitigating long-term cardiometabolic risks. Effective evidence-based strategies for improving sleep behaviors and cardiometabolic health, beyond addressing sleep disorders, include prioritizing sleep hygiene, managing stress, promoting physical activity, maintaining a healthy diet, and reducing substance use, all of which contribute to overall well-being. In conclusion, incorporating sleep health into routine cardiometabolic risk stratification, prevention, and management is essential for improving overall health outcomes.
C1 [Chaput, Jean-Philippe] Childrens Hosp Eastern Ontario, Res Inst, Hlth Act Living & Obes Res Grp, Ottawa, ON, Canada.
   [Chaput, Jean-Philippe] Univ Ottawa, Fac Med, Dept Pediat, Ottawa, ON, Canada.
   [Stranges, Saverio] Western Univ, Schulich Sch Med & Dent, Dept Epidemiol & Biostat, London, ON, Canada.
   [Stranges, Saverio] Western Univ, Schulich Sch Med & Dent, Dept Family Med, London, ON, Canada.
   [Stranges, Saverio] Western Univ, Schulich Sch Med & Dent, Dept Med, London, ON, Canada.
   [Stranges, Saverio] Univ Naples Federico II, Dept Clin Med & Surg, Naples, Italy.
C3 University of Ottawa; Children's Hospital of Eastern Ontario; University
   of Ottawa; Western University (University of Western Ontario); Western
   University (University of Western Ontario); Western University
   (University of Western Ontario); University of Naples Federico II
RP Chaput, JP (corresponding author), Childrens Hosp Eastern Ontario, Res Inst, Hlth Act Living & Obes Res Grp, Ottawa, ON, Canada.
EM jpchaput@cheo.on.ca
RI Chaput, Jean-Philippe/ABE-6307-2020; subramaniyan,
   vetriselvan/AAC-5548-2020
OI Chaput, Jean-Philippe/0000-0002-5607-5736
FU Canadian Institutes of Health Research, Team Grant: Sleep Research
   Consortium
FX This manuscript was supported by the Canadian Institutes of Health
   Research, Team Grant: Sleep Research Consortium.
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NR 85
TC 0
Z9 0
U1 2
U2 2
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 0939-4753
EI 1590-3729
J9 NUTR METAB CARDIOVAS
JI Nutr. Metab. Carbiovasc. Dis.
PD MAR
PY 2025
VL 35
IS 3
AR 103782
DI 10.1016/j.numecd.2024.10.020
EA FEB 2025
PG 7
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism; Nutrition
   & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism;
   Nutrition & Dietetics
GA Z1N4Q
UT WOS:001436658400001
PM 39643476
DA 2025-06-11
ER

PT J
AU Perez-Martinez, P
   Phillips, CM
   Delgado-Lista, J
   Garcia-Rios, A
   Lopez-Miranda, J
   Perez-Jimenez, F
AF Perez-Martinez, Pablo
   Phillips, Catherine M.
   Delgado-Lista, Javier
   Garcia-Rios, Antonio
   Lopez-Miranda, Jose
   Perez-Jimenez, Francisco
TI Nutrigenetics, Metabolic Syndrome Risk and Personalized Nutrition
SO CURRENT VASCULAR PHARMACOLOGY
LA English
DT Article
DE Diet; gene-diet interaction; nutrigenomics; metabolic syndrome;
   polymorphism; diabetes mellitus
ID GENE-NUTRIENT INTERACTIONS; CCAAT/ENHANCER BINDING-PROTEIN; DIETARY-FAT
   MODIFICATION; INSULIN SENSITIVITY; INFLAMMATORY MARKERS; OXIDATIVE
   STRESS; ACID-COMPOSITION; ADIPOSE-TISSUE; PIMA-INDIANS; POLYMORPHISMS
AB The metabolic syndrome (MetS) is a constellation of metabolic risk factors reflecting overnutrition and sedentary lifestyle and its increasing prevalence is reaching epidemic proportions. The importance of MetS lies in its close association with the risk of cardiometabolic disease. In this scenario, the principal goals of pharmacological therapy for these patients are to achieve and maintain an optimal cardiometabolic control, including lipids, blood glucose and blood pressure; in order to prevent and treat potential complications. Moreover nutrition has commonly been accepted as a cornerstone of treatment for MetS, with the expectation that an appropriate intake of energy and nutrients will improve its control. However the question arises as to whether dietary therapy may require a more personalised approach. In this regard improvements in genetic analysis have enhanced our understanding of the role of genetics in this diet-related condition. In this review we will present recent data highlighting the importance of gene-nutrient interactions in the context of MetS risk.
C1 [Perez-Martinez, Pablo; Delgado-Lista, Javier; Garcia-Rios, Antonio; Lopez-Miranda, Jose; Perez-Jimenez, Francisco] Univ Cordoba, Reina Sofia Univ Hosp, IMIBIC, Lipid & Atherosclerosis Unit, E-14071 Cordoba, Spain.
   [Perez-Martinez, Pablo; Delgado-Lista, Javier; Garcia-Rios, Antonio; Lopez-Miranda, Jose; Perez-Jimenez, Francisco] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr CIBEROBN, Madrid, Spain.
   [Phillips, Catherine M.] Univ Coll Cork, Dept Epidemiol & Publ Hlth, Cork, Ireland.
C3 Universidad de Cordoba; Hospital Universitario Reina Sofia - Cordoba;
   CIBER - Centro de Investigacion Biomedica en Red; CIBEROBN; Instituto de
   Salud Carlos III; University College Cork
RP Perez-Martinez, P (corresponding author), Reina Sofia Univ Hosp, Lipids & Atherosclerosis Res Unit, Avda Menendez Pidal S-N, Cordoba 14004, Spain.
EM pablopermar@yahoo.es
RI Jimenez, Francisco/AAJ-9559-2021; Delgado-Lista, Javier/KAM-7412-2024;
   Lopez-Miranda, Jose/Y-8306-2019; Tejada, Silvia/L-7297-2014; Phillips,
   Catherine/E-4412-2013; Perez Martinez, Pablo/AEL-6176-2022
OI Lopez-Miranda, Jose/0000-0002-8844-0718; Perez Martinez,
   Pablo/0000-0001-7716-8117; Perez Jimenez, Francisco/0000-0001-9808-1280;
   Delgado Lista, Francisco Javier/0000-0002-2982-2716; Phillips,
   Catherine/0000-0003-4916-4463; Perez-Jimenez,
   Francisco/0000-0001-7499-7681
FU Spanish Ministry of Science and Innovation [AGL 2004-07907,
   AGL2006-01979, AGL2009-12270, SAF07-62005, FIS PI10/01041, PI10/02412];
   Consejeria de Economia, Innovacion y Ciencia, Proyectos de Investigacion
   de Excelencia, Junta de Andalucia [P06-CTS-01425, CTS5015, AGR922];
   Consejeria de Salud, Junta de Andalucia [06/128, 07/43, PI0193/09,
   06/129, 0118/08, PI-0252/09, PI-0058/10]; Fondo Europeo de Desarrollo
   Regional (FEDER); Centro de Excelencia Investigadora en Aceite de Oliva
   y Salud (CEAS); ISCIII (Programa Rio-Hortega)
FX Supported in part by public funds: research grants from the Spanish
   Ministry of Science and Innovation (AGL 2004-07907, AGL2006-01979, and
   AGL2009-12270 to J L-M, SAF07-62005 to F P-J and FIS PI10/01041 to P
   P-M, PI10/02412 to F P-J); Consejeria de Economia, Innovacion y Ciencia,
   Proyectos de Investigacion de Excelencia, Junta de Andalucia
   (P06-CTS-01425 to J L-M, CTS5015 and AGR922 to F P-J); Consejeria de
   Salud, Junta de Andalucia (06/128, 07/43, and PI0193/09 to J L-M, 06/129
   to F P-J, 0118/08 to F F-J, PI-0252/09 to J D-L, and PI-0058/10 to P
   P-M); Fondo Europeo de Desarrollo Regional (FEDER); Centro de Excelencia
   Investigadora en Aceite de Oliva y Salud (CEAS). The CIBEROBN is an
   initiative of the Instituto de Salud Carlos III, Madrid, Spain. AG-R is
   supported by a research contract of ISCIII (Programa Rio-Hortega). None
   of the authors has any conflict of interest.
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NR 64
TC 10
Z9 10
U1 0
U2 23
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1570-1611
EI 1875-6212
J9 CURR VASC PHARMACOL
JI Current Vascular Pharmacology
PD NOV
PY 2013
VL 11
IS 6
BP 946
EP 953
DI 10.2174/157016111106140128120911
PG 8
WC Pharmacology & Pharmacy; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Cardiovascular System & Cardiology
GA AA4IC
UT WOS:000331058300013
PM 24168447
DA 2025-06-11
ER

PT J
AU Wang, YB
   Yu, QJ
   Chen, YD
   Cao, F
AF Wang, Yabin
   Yu, Qiujun
   Chen, Yundai
   Cao, Feng
TI Pathophysiology and Therapeutics of Cardiovascular Disease in Metabolic
   Syndrome
SO CURRENT PHARMACEUTICAL DESIGN
LA English
DT Article
DE Metabolic syndrome; cardiovascular disease; insulin resistance; obesity;
   diabetes; dyslipidemia
ID BODY-MASS INDEX; INSULIN-RESISTANCE; ANTIDIABETIC THERAPY;
   GLUCOSE-HOMEOSTASIS; LDL-CHOLESTEROL; BLOOD-GLUCOSE; HEART-DISEASE;
   HYPERTENSION; OBESITY; RISK
AB The metabolic syndrome (MetS) is characterized by a cluster of cardiovascular risk factors, including central obesity, hyperglycemia, dyslipidemia and hypertension, which are highly associated with increased morbidity and mortality of cardiovascular diseases (CVD). The association between these metabolic disorders and the development of CVD is believed to be multifactorial, where insulin resistance, oxidative stress, low-grade inflammation and vascular maladaptation act as the major contributors. Therefore, multipronged therapeutic strategies should be taken for the management of patients with MetS. Lifestyle changes including weight control, healthy heart diet and regular exercises have been proposed as first line treatment to decrease CVD risks in MetS individuals. In addition, improving insulin resistance and glucose metabolism, controlling blood pressure as well as modulating dyslipidemia can also delay or reverse the progression of CVD in MetS. This review will first address the complicated interactions between MetS and CVD, followed by discussion about the optimal strategy in the prevention and treatment of CVD in MetS patients and the updated results from newly released clinical trials.
C1 [Wang, Yabin; Yu, Qiujun; Cao, Feng] Fourth Mil Med Univ, Xijing Hosp, Dept Cardiol, Xian 710032, Shaanxi, Peoples R China.
   [Chen, Yundai] Gen Hosp PLA, Dept Cardiol, Beijing 100039, Peoples R China.
C3 Air Force Medical University; Chinese People's Liberation Army General
   Hospital
RP Cao, F (corresponding author), Fourth Mil Med Univ, Xijing Hosp, Dept Cardiol, Xian 710032, Shaanxi, Peoples R China.
EM wind8828@gmail.com
RI chen, yundai/I-4353-2019; Yu, Qiujun/B-6794-2015; Wang,
   Yabin/HLG-3966-2023
FU National Nature Science Foundation of China [81270168, 81090274,
   81090270, 81227901]; Innovation Team Development Grant by China
   Department of Education [2010CXTD01, IRT1053]; FCAO [BWS12J037]
FX This work was supported by National Nature Science Foundation of China
   (No. 81270168, No. 81090274, 81090270, 81227901), FCAO(BWS12J037);
   Innovation Team Development Grant by China Department of Education
   (2010CXTD01, IRT1053).
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NR 64
TC 25
Z9 27
U1 1
U2 11
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1381-6128
EI 1873-4286
J9 CURR PHARM DESIGN
JI Curr. Pharm. Design
PD AUG
PY 2013
VL 19
IS 27
BP 4799
EP 4805
DI 10.2174/1381612811319270002
PG 7
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 172ZA
UT WOS:000321045100002
PM 23323622
DA 2025-06-11
ER

PT J
AU Gaspard, U
AF Gaspard, Ulysse
TI Hyperinsulinaemia, a key factor of the metabolic syndrome in
   postmenopausal women
SO MATURITAS
LA English
DT Review
DE Postmenopause; Metabolic syndrome; Cardiovascular risk in women;
   Diabetes in women; Insulin resistance; Obesity; Adipocytokines
ID HORMONE-REPLACEMENT THERAPY; BODY-FAT DISTRIBUTION; INSULIN SENSITIVITY;
   ADIPOSE-TISSUE; CONSENSUS STATEMENT; CARDIOVASCULAR RISK;
   GLUCOSE-TOLERANCE; MENOPAUSE; RESISTANCE; ADIPONECTIN
AB The metabolic syndrome (MetS) is a complex disorder combining obesity, hypertension, atherogenic dyslipidaemia and insulin resistance, a clustering of factors which markedly enhance the risk of developing cardiovascular disease (CVD) and type 2 diabetes. Main features of the MetS, which are found in many postmenopausal women, are increasing prevalence of insulin resistance and obesity (particularly visceral adiposity). Accordingly, a majority of postmenopausal women comply with criteria defining the MetS, and CVD is the first cause of morbidity/mortality in women, occurring even more frequently than in men. Moreover, obesity-related type 2 diabetes approaches pandemic proportions. Simultaneous occurrence of insulin resistance and obesity are most detrimental for metabolic health, and are also associated with increased oxidative stress, inflammatory and prothrombotic processes as well as with postmenopausal alterations in adipocytokine production. Hormone replacement therapy, provided the selected progestin does not antagonize estrogen action, may improve fat mass and distribution, dyslipidaemia and insulin sensitivity in postmenopausal women. (c) 2009 Elsevier Ireland Ltd. All rights reserved.
C1 Univ Liege, Sart Tilman Univ Hosp, Dept Obstet & Gynaecol, B-4000 Liege 1, Belgium.
C3 University of Liege
RP Gaspard, U (corresponding author), Univ Liege, Sart Tilman Univ Hosp, Dept Obstet & Gynaecol, B-4000 Liege 1, Belgium.
EM u.gaspard@chu.ulg.ac.be
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NR 40
TC 54
Z9 62
U1 0
U2 3
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0378-5122
EI 1873-4111
J9 MATURITAS
JI Maturitas
PD APR 20
PY 2009
VL 62
IS 4
SI SI
BP 362
EP 365
DI 10.1016/j.maturitas.2008.11.026
PG 4
WC Geriatrics & Gerontology; Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology; Obstetrics & Gynecology
GA 450VZ
UT WOS:000266430600009
PM 19131194
DA 2025-06-11
ER

EF﻿FN Clarivate Analytics Web of Science
VR 1.0
PT J
AU Levitt, DE
   Wohlgemuth, KJ
   Burnham, EF
   Conner, MJ
   Collier, JJ
   Mota, JA
AF Levitt, Danielle E.
   Wohlgemuth, Kealey J.
   Burnham, Emilie F.
   Conner, Michael J.
   Collier, J. Jason
   Mota, Jacob A.
TI Hazardous alcohol use and cardiometabolic risk among firefighters
SO ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH
LA English
DT Article
DE ethanol; first responder; mental health; occupational health; tactical
   athlete
ID BLOOD-PRESSURE; POSTTRAUMATIC-STRESS; METABOLIC SYNDROME; INSOMNIA
   SEVERITY; DEPRESSION; ASSOCIATION; ANXIETY; PREDICTORS; DISORDER;
   DRINKING
AB BackgroundAlcohol misuse is prevalent among firefighters, and associated adverse cardiometabolic health consequences could negatively impact readiness for duty. Mental health conditions may confer additional risk. Therefore, we aimed to determine whether alcohol misuse increases cardiometabolic risk among firefighters and whether mental health conditions modify these relationships. MethodsDeidentified data from firefighters (N = 2405; 95.8% males, 38 +/- 9 years, 29.6 +/- 4.6 kg/m2) included demographics, Alcohol Use Disorders Identification Test (AUDIT) and AUDIT-C scores, mental health screening scores, anthropometrics, metabolic panel, and cardiorespiratory testing results. Differences in cardiometabolic parameters between firefighters with low AUDIT-C (<3 [females] or <4 [males]; no or low-risk alcohol use) or high AUDIT-C (>= 3 [females] or >= 4 [males]; hazardous alcohol use) were determined and odds ratios for clinical risk factors were calculated. Posttraumatic stress disorder (PTSD), insomnia, depression, and anxiety were assessed as moderators. ResultsFirefighters with high AUDIT-C had significantly (p < 0.05) higher total cholesterol (TC), high-density lipoprotein (HDL-C), and systolic blood pressure (SBP) and diastolic blood pressure (DBP) and lower hemoglobin A1C (HbA1c) than those with low AUDIT-C. In unadjusted and/or adjusted analyses, those with high AUDIT-C had increased risk for overweight/obesity, hypercholesterolemia, and prehypertension/hypertension, and decreased risk for low HDL and elevated HbA1c. There were inverse moderation effects by posttraumatic stress disorder (PTSD), depression, and anxiety on relationships between AUDIT-C score and BP. Insomnia (directly) and anxiety (inversely) moderated relationships between AUDIT-C score and circulating lipids. ConclusionsFirefighters with high AUDIT-C have differential cardiometabolic risk, with specific relationships altered by mental health status. Whether higher HDL and lower HbA1c with high AUDIT-C in firefighters is protective long-term remains to be explored. Overall, these results underscore the need for alcohol screening and intervention to maintain cardiometabolic health and long-term occupational readiness among firefighters.
C1 [Levitt, Danielle E.] Texas Tech Univ, Dept Kinesiol & Sport Management, Metab Hlth & Muscle Physiol Lab, Lubbock, TX USA.
   [Wohlgemuth, Kealey J.; Mota, Jacob A.] Texas Tech Univ, Dept Kinesiol & Sport Management, Neuromuscular & Occupat Performance Lab, Lubbock, TX USA.
   [Burnham, Emilie F.; Conner, Michael J.] Front Line Mobile Hlth, Georgetown, TX USA.
   [Collier, J. Jason] Pennington Biomed Res Ctr, Lab Islet Biol & Inflammat, Baton Rouge, LA USA.
C3 Texas Tech University System; Texas Tech University; Texas Tech
   University System; Texas Tech University; Louisiana State University
   System; Louisiana State University; Pennington Biomedical Research
   Center
RP Levitt, DE (corresponding author), Texas Tech Univ, Dept Kinesiol & Sport Management, 2500 Broadway St,Box 43011, Lubbock, TX 79409 USA.
EM danielle.levitt@ttu.edu
RI Mota, Jacob/T-2128-2019
OI Conner, Michael/0009-0000-6870-1485; Levitt,
   Danielle/0000-0003-1865-1971
FU Texas Tech University [2024]
FX The authors are grateful to the individuals whose deidentified
   information allowed us to conduct this work. We thank the staff of Front
   Line Mobile Health, LLC, for conducting comprehensive physical
   examinations for first responders, enabling these essential personnel to
   make informed decisions regarding their health, and for providing the
   deidentified data used herein. We also thank Ronald Budnar, Jr., for
   analytical assistance. The e-Table of Contents summary figure was
   created in BioRender: Levitt, D. (2024) .
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NR 60
TC 0
Z9 0
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
EI 2993-7175
J9 ALCOHOL CLIN EXP RES
JI Alcohol Clin. Exp. Res.
PD FEB
PY 2025
VL 49
IS 2
BP 392
EP 406
DI 10.1111/acer.15517
EA JAN 2025
PG 15
WC Substance Abuse
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Substance Abuse
GA X1I5K
UT WOS:001406430000001
PM 39746845
DA 2025-06-11
ER

PT J
AU Armborst, D
   Bitterlich, N
   Alteheld, B
   Rösler, D
   Metzner, C
   Siener, R
AF Armborst, Deborah
   Bitterlich, Norman
   Alteheld, Birgit
   Roesler, Daniela
   Metzner, Christine
   Siener, Roswitha
TI Coping Strategies Influence Cardiometabolic Risk Factors in Chronic
   Psychological Stress: A Post Hoc Analysis of A Randomized Pilot Study
SO NUTRIENTS
LA English
DT Article
DE stress management; perceived stress questionnaire (PSQ(30));
   psychological neurological questionnaire (PNF); visceral adiposity;
   fatty liver index (FLI); cardiometabolic risk;
   hypothalamic-pituitary-adrenal (HPA) axis; coping strategies; stress
   habituation
ID GERMAN HEALTH INTERVIEW; METABOLIC SYNDROME; PERCEIVED STRESS; SELFISH
   BRAIN; NORMAL-WEIGHT; BODY SHAPE; URIC-ACID; ALL-CAUSE; OBESITY;
   CORTISOL
AB Chronic psychological stress can result in physiological and mental health risks via the activation of the hypothalamic-pituitary-adrenal (HPA) axis, sympathoadrenal activity and emotion-focused coping strategies. The impact of different stress loads on cardiometabolic risk is poorly understood. This post hoc analysis of a randomized pilot study was conducted on 61 participants (18-65 years of age) with perceived chronic stress. The Perceived Stress Questionnaire (PSQ(30)), Psychological Neurological Questionnaire (PNF), anthropometric, clinical and blood parameters were assessed. Subjects were assigned to 'high stress' (HS; PSQ(30) score: 0.573 +/- 0.057) and 'very high stress' (VHS; PSQ(30) score: 0.771 +/- 0.069) groups based on the PSQ(30). Morning salivary cortisol and CRP were elevated in both groups. Visceral adiposity, elevated blood pressure and metabolic syndrome were significantly more frequent in the HS group vs. the VHS group. The fatty liver index (FLI) was higher (p = 0.045), while the PNF score was lower (p < 0.001) in the HS group. The HS group was comprised of more smokers (p = 0.016). Energy intake and physical activity levels were similar in both groups. Thus, high chronic stress was related to visceral adiposity, FLI, elevated blood pressure and metabolic syndrome in the HS group, while very high chronic stress was associated with psychological-neurological symptoms and a lower cardiometabolic risk in the VHS group, probably due to different coping strategies.
C1 [Armborst, Deborah; Siener, Roswitha] Univ Hosp Bonn, Dept Urol, Med Nutr Sci, Venusberg Campus 1, D-53127 Bonn, Germany.
   [Bitterlich, Norman] Med & Serv Ltd, Dept Biostat, Boettcherstr 10, D-09117 Chemnitz, Germany.
   [Alteheld, Birgit] Univ Bonn, Nutr Physiol, Dept Nutr & Food Sci, Nussallee 9, D-53115 Bonn, Germany.
   [Roesler, Daniela; Metzner, Christine] Bonn Educ Assoc Dietet rA, Fuerst Pueckler Str 44, D-50935 Cologne, Germany.
   [Metzner, Christine] Rhein Westfal TH Aachen, Clin Gastroenterol Metab Disorders & Internal Int, Med Clin 3, Pauwelsstr 44, D-52074 Aachen, Germany.
C3 University of Bonn; University of Bonn; RWTH Aachen University
RP Armborst, D (corresponding author), Univ Hosp Bonn, Dept Urol, Med Nutr Sci, Venusberg Campus 1, D-53127 Bonn, Germany.
EM s7dearmb@uni-bonn.de; bitterlich@medizinservice-sachsen.de;
   b.alteheld@uni-bonn.de; office@bfdev.de;
   christine.metzner@rwth-aachen.de; Roswitha.Siener@ukbonn.de
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NR 103
TC 3
Z9 4
U1 1
U2 12
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD JAN
PY 2022
VL 14
IS 1
AR 77
DI 10.3390/nu14010077
PG 20
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nutrition & Dietetics
GA YT2ZB
UT WOS:000751232600001
PM 35010951
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Countryman, AJ
   Saab, PG
   Schneiderman, N
   McCalla, JR
   Llabre, MM
AF Countryman, Amanda J.
   Saab, Patrice G.
   Schneiderman, Neil
   McCalla, Judith R.
   Llabre, Maria M.
TI Cardiovascular Reactivity and Cardiometabolic Risk in Adolescents
SO INTERNATIONAL JOURNAL OF BEHAVIORAL MEDICINE
LA English
DT Article
DE Cardiovascular reactivity; Cardiometabolic risk; Metabolic syndrome;
   Autonomic dysfunction; Adolescents
ID INSULIN-RESISTANCE SYNDROME; BODY-MASS INDEX; METABOLIC SYNDROME;
   BLOOD-PRESSURE; MENTAL STRESS; BAROREFLEX SENSITIVITY; BEHAVIORAL
   CHALLENGES; PSYCHOLOGICAL STRESS; REFLEX ABNORMALITIES; SCIENTIFIC
   STATEMENT
AB Background Cardiovascular reactivity has been examined as a risk marker or factor in the pathogenesis of hypertension or cardiovascular disease, but few have examined the relationship with the metabolic syndrome.
   Purpose We examined whether cardiovascular reactivity to laboratory stress is associated with individual cardiometabolic risk factors and their co-occurrence. A significant positive relationship was hypothesized for both individual and clustered risk factors in their cross-sectional associations with reactivity to multiple stressors.
   Methods A sample of 144, 15-17-year-old adolescents (74 % boys) largely from ethnic minority groups (54 % Hispanic White, 26 % Black) were identified at annual blood pressure (BP) screening (39 % with elevated BP) at high schools in Miami, Florida, USA. Participants completed the evaluated speaking, mirror star tracing, and cold pressor tasks, as well as cardiometabolic risk factor blood sampling. Participants were classified into metabolic syndrome criterion groups (0, 1, 2, or a parts per thousand yen3 criteria) based on American Heart Association adult criteria.
   Results Multiple regression analyses with individual metabolic syndrome variables demonstrated that diastolic (D)BP reactivity during the mirror star tracing task accounted for 1.3 %, 3.8 %, and 5.1 % of the respective variances in casual systolic BP, waist circumference, and triglycerides (ps < 0.05). In multinomial logistic regression models, increased DBP reactivity during mirror star tracing and cold pressor tasks, and decreased HR reactivity during the cold pressor, were associated with greater likelihood of risk factor co-occurrence (ranging from 8.3 % to 15.8 %).
   Conclusions Findings indicate that autonomic reactivity to the mirror star tracing and cold pressor tasks, but not the evaluated speaking task, is associated with risk factor co-occurrence, and reactivity may be a clinical prognosticator of cardiometabolic disease risk.
C1 [Countryman, Amanda J.; Saab, Patrice G.; Schneiderman, Neil; McCalla, Judith R.; Llabre, Maria M.] Univ Miami, Dept Psychol, Coral Gables, FL 33146 USA.
C3 University of Miami
RP Countryman, AJ (corresponding author), Univ Miami, Dept Psychol, 5665 Ponce Leon Blvd, Coral Gables, FL 33146 USA.
EM amanda.countryman@gmail.com; psaab@miami.edu; nschneid@miami.edu;
   jmccalla@miami.edu; mllabre@miami.edu
FU NHLBI NIH HHS [HL36588] Funding Source: Medline
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NR 43
TC 1
Z9 1
U1 0
U2 6
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1070-5503
EI 1532-7558
J9 INT J BEHAV MED
JI Int. J. Behav. Med.
PD FEB
PY 2014
VL 21
IS 1
BP 122
EP 130
DI 10.1007/s12529-012-9280-z
PG 9
WC Psychology, Clinical
WE Social Science Citation Index (SSCI)
SC Psychology
GA AB7XY
UT WOS:000332005600014
PM 23160997
DA 2025-06-11
ER

PT J
AU Mundhra, R
   Kumari, P
   Bahadur, A
   Khoiwal, K
   Gill, P
   Latha, RM
   Naithani, M
   Chaturvedi, J
AF Mundhra, Rajlaxmi
   Kumari, Purvashi
   Bahadur, Anupama
   Khoiwal, Kavita
   Gill, Poonam
   Latha, Ratala Madhavi
   Naithani, Manisha
   Chaturvedi, Jaya
TI Relationship between Metabolic Syndrome and Mental Health Status among
   Geriatric Females: A Cross-sectional Study
SO JOURNAL OF MID-LIFE HEALTH
LA English
DT Article
DE Geriatric females; mental health;
   metabolic syndrome
ID PREVALENCE
AB Introduction:Postmenopausal status is a known risk factors for developing metabolic syndrome (MetS). Studies focusing on establishing the relationship between Mets and mental health state are limited.Aims and Objective:To identify the frequency of MetS along with its components in geriatric females and assess its relationship with three negative emotional states (depression/anxiety/stress).Materials and Methods:Women aged >= 60 years from October 2020 to March 2022 were included in study. We used the Consensus Definition IDF and AHA/NHLBI (2009) criteria to classify subjects as having metabolic syndrome. Mental health status were assessed using Depression Anxiety and Stress Scale (DASS 21) questionnaire.Results:The frequency of metabolic syndrome in this sample was 36.58% (30 out of 82 patients). The Depression, anxiety, stress scale and total scores in women with MetS were 14 +/- 5.3, 8.5 +/- 3.92, 12.13 +/- 5.58 and 34.66 +/- 9.60 as compared to 6.6 +/- 3.7, 5.3 +/- 2.49, 7.1 +/- 3.12 and 19.2 +/- 6.51 in those without MetS; difference being statistically significant.Conclusion:MetS results in poor mental health state in geriatric women but large-scale studies are needed to clarify this association.
C1 [Mundhra, Rajlaxmi; Kumari, Purvashi; Bahadur, Anupama; Khoiwal, Kavita; Gill, Poonam; Latha, Ratala Madhavi; Chaturvedi, Jaya] All India Inst Med Sci, Dept Obstet & Gynecol, Rishikesh 249203, Uttarakhand, India.
   [Naithani, Manisha] All India Inst Med Sci, Dept Biochem, Rishikesh, Uttarakhand, India.
C3 All India Institute of Medical Sciences (AIIMS) Rishikesh; All India
   Institute of Medical Sciences (AIIMS) Rishikesh
RP Mundhra, R (corresponding author), All India Inst Med Sci, Dept Obstet & Gynecol, Rishikesh 249203, Uttarakhand, India.
EM rmundhra54@yahoo.com
RI Bahadur, Anupama/AAX-7428-2020; naithani, manisha/AAS-1909-2021
CR Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
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NR 21
TC 0
Z9 0
U1 0
U2 0
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, Maharashtra, INDIA
SN 0976-7800
EI 0976-7819
J9 J MID-LIFE HEALTH
JI J. Mid-Life Health
PD OCT-DEC
PY 2024
VL 15
IS 4
BP 264
EP 268
DI 10.4103/jmh.jmh_168_24
PG 5
WC Obstetrics & Gynecology
WE Emerging Sources Citation Index (ESCI)
SC Obstetrics & Gynecology
GA R1G9X
UT WOS:001389035500004
PM 39959727
OA gold
DA 2025-06-11
ER

PT J
AU Yap, RWK
   Lin, MH
   Shidoji, Y
   Yap, WS
AF Yap, Roseline W. K.
   Lin, Mei-Hua
   Shidoji, Yoshihiro
   Yap, Wai Sum
TI Association of Stress, Mental Health, and VEGFR-2 Gene Polymorphisms
   with Cardiometabolic Risk in Chinese Malaysian Adults
SO NUTRIENTS
LA English
DT Article
DE gene-environment interaction; VEGFR-2 gene; rs1870377; rs2071559; job
   stress; mental health; cardiometabolic risk; Chinese Malaysian adults
ID ENDOTHELIAL GROWTH-FACTOR; CARDIOVASCULAR RISK; BLOOD-GLUCOSE;
   LIPID-LEVELS; APOLIPOPROTEINS; DEPRESSION; ANXIETY; DISEASE
AB Gene-environment (G x E) interactions involving job stress and mental health on risk factors of cardiovascular disease (CVD) are minimally explored. This study examined the association and G x E interaction effects of vascular endothelial growth factor receptor-2 (VEGFR-2) gene polymorphisms (rs1870377, rs2071559) on cardiometabolic risk in Chinese Malaysian adults. Questionnaires: Job Stress Scale (JSS); Depression, Anxiety, and Stress Scale (DASS-21); and Rhode Island Stress and Coping Inventory (RISCI) were used to measure job stress, mental health, and coping with perceived stress. Cardiometabolic risk parameters were evaluated in plasma and genotyping analysis was performed by real-time polymerase chain reaction. The subjects were 127 Chinese Malaysian adults. The allele frequencies for rs1870377 (A allele and T allele) and rs2071557 (A allele and T allele) polymorphisms were 0.48 and 0.52, and 0.37 and 0.63, respectively. Significant correlations include scores from JSS dimensions with blood glucose (BG) (p = 0.025-0.045), DASS-21 dimensions with blood pressure, BMI, and uric acid (p = 0.029-0.047), and RISCI with blood pressure and BG (p = 0.016-0.049). Significant G x E interactions were obtained for: rs1870377 with stress on total cholesterol (p = 0.035), low density lipoprotein cholesterol (p = 0.019), and apolipoprotein B100 (p = 0.004); and rs2071559 with anxiety on blood pressure (p = 0.006-0.045). The significant G x E interactions prompt actions for managing stress and anxiety for the prevention of CVD.
C1 [Yap, Roseline W. K.] Taylors Univ, Sch Biosci, Subang Jaya 47500, Selangor, Malaysia.
   [Lin, Mei-Hua] Sunway Univ, Sch Sci & Technol Psychol, Selangor 47500, Malaysia.
   [Shidoji, Yoshihiro] Univ Nagasaki, Grad Sch Human Hlth Sci, Nagayo Cho, Nagasaki 8512195, Japan.
   [Yap, Wai Sum] UCSI Univ, Fac Sci Appl, Kuala Lumpur 56000, Malaysia.
C3 Taylor's University; Sunway University; Nagasaki University; UCSI
   University
RP Yap, RWK (corresponding author), Taylors Univ, Sch Biosci, Subang Jaya 47500, Selangor, Malaysia.
EM roselinewaikuan.yap@taylors.edu.my; shidoji@sun.ac.jp;
   shidoji@sun.ac.jp; wsyap@ucsiuniversity.edu.my
RI Lin, Mei-Hua/HLW-8397-2023; Yap, Wai-Sum/AAS-1047-2020
OI Shidoji, Yoshihiro/0000-0002-2136-6752; Lin, Mei-Hua/0000-0002-2873-5426
FU Taylor's Research Grant Scheme-Major Funding Scheme of Taylor's
   University [TRGS/MFS/1/2015/SBS/004]; Taylor's University
FX This research was funded by Taylor's Research Grant Scheme-Major Funding
   Scheme of Taylor's University (grant number TRGS/MFS/1/2015/SBS/004).
   This publication was supported by Taylor's University.
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PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD MAY
PY 2019
VL 11
IS 5
AR 1140
DI 10.3390/nu11051140
PG 13
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA IC5PY
UT WOS:000471021600200
PM 31121870
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Shea, S
   Lionis, C
   Kite, C
   Atkinson, L
   Chaggar, SS
   Randeva, HS
   Kyrou, I
AF Shea, Sue
   Lionis, Christos
   Kite, Chris
   Atkinson, Lou
   Chaggar, Surinderjeet S.
   Randeva, Harpal S.
   Kyrou, Ioannis
TI Non-Alcoholic Fatty Liver Disease (NAFLD) and Potential Links to
   Depression, Anxiety, and Chronic Stress
SO BIOMEDICINES
LA English
DT Review
DE non-alcoholic fatty liver disease; NAFLD; NASH; metabolic syndrome;
   insulin resistance; obesity; depression; anxiety; stress; health related
   quality of life
ID QUALITY-OF-LIFE; METABOLIC SYNDROME; PSYCHOLOGICAL DISTRESS;
   CARDIOVASCULAR-DISEASE; HEALTH; ASSOCIATION; COMORBIDITY; SYMPTOMS;
   OBESITY; ADULTS
AB Non-alcoholic fatty liver disease (NAFLD) constitutes the most common liver disease worldwide, and is frequently linked to the metabolic syndrome. The latter represents a clustering of related cardio-metabolic components, which are often observed in patients with NAFLD and increase the risk of cardiovascular disease. Furthermore, growing evidence suggests a positive association between metabolic syndrome and certain mental health problems (e.g., depression, anxiety, and chronic stress). Given the strong overlap between metabolic syndrome and NAFLD, and the common underlying mechanisms that link the two conditions, it is probable that potentially bidirectional associations are also present between NAFLD and mental health comorbidity. The identification of such links is worthy of further investigation, as this can inform more targeted interventions for patients with NAFLD. Therefore, the present review discusses published evidence in relation to associations of depression, anxiety, stress, and impaired health-related quality of life with NAFLD and metabolic syndrome. Attention is also drawn to the complex nature of affective disorders and potential overlapping symptoms between such conditions and NAFLD, while a focus is also placed on the postulated mechanisms mediating associations between mental health and both NAFLD and metabolic syndrome. Relevant gaps/weaknesses of the available literature are also highlighted, together with future research directions that need to be further explored.
C1 [Shea, Sue; Randeva, Harpal S.; Kyrou, Ioannis] Univ Warwick, Warwick Med Sch, Coventry CV4 7AL, W Midlands, England.
   [Shea, Sue; Kite, Chris; Atkinson, Lou; Randeva, Harpal S.; Kyrou, Ioannis] Univ Hosp Coventry & Warwickshire NHS Trust, Warwickshire Inst Study Diabet Endocrinol & Metab, Coventry CV2 2DX, W Midlands, England.
   [Lionis, Christos] Univ Crete, Sch Med, Clin Social & Family Med, Iraklion 71003, Greece.
   [Kite, Chris] Univ Chester, Univ Ctr Shrewsbury, Ctr Active Living, Shrewsbury SY3 8HQ, Salop, England.
   [Kite, Chris; Kyrou, Ioannis] Coventry Univ, Res Inst Hlth & Wellbeing, Ctr Sport Exercise & Life Sci, Coventry CV1 5FB, W Midlands, England.
   [Atkinson, Lou] Aston Univ, Sch Psychol, Coll Hlth & Life Sci, Birmingham B4 7ET, W Midlands, England.
   [Chaggar, Surinderjeet S.] Forum Hlth Ctr, Sowe Valley Primary Care Network, Coventry CV2 5EP, W Midlands, England.
   [Kyrou, Ioannis] Aston Univ, Aston Med Sch, Coll Hlth & Life Sci, Birmingham B4 7ET, W Midlands, England.
   [Kyrou, Ioannis] Agr Univ Athens, Dept Food Sci & Human Nutr, Athens 11855, Greece.
C3 University of Warwick; University of Warwick; University of Crete;
   Coventry University; Aston University; Aston University; Agricultural
   University of Athens
RP Randeva, HS; Kyrou, I (corresponding author), Univ Warwick, Warwick Med Sch, Coventry CV4 7AL, W Midlands, England.; Randeva, HS; Kyrou, I (corresponding author), Univ Hosp Coventry & Warwickshire NHS Trust, Warwickshire Inst Study Diabet Endocrinol & Metab, Coventry CV2 2DX, W Midlands, England.; Kyrou, I (corresponding author), Coventry Univ, Res Inst Hlth & Wellbeing, Ctr Sport Exercise & Life Sci, Coventry CV1 5FB, W Midlands, England.; Kyrou, I (corresponding author), Aston Univ, Aston Med Sch, Coll Hlth & Life Sci, Birmingham B4 7ET, W Midlands, England.; Kyrou, I (corresponding author), Agr Univ Athens, Dept Food Sci & Human Nutr, Athens 11855, Greece.
EM sue.shea@warwick.ac.uk; lionis@galinos.med.uoc.gr; c.kite@chester.ac.uk;
   l.atkinson1@aston.ac.uk; surinder.chaggar@nhs.net;
   harpal.randeva@uhcw.nhs.uk; ad6702@coventry.ac.uk
RI Lionis, Christos/MBV-1499-2025
OI Lionis, Christos/0000-0002-9324-2839; Kite, Chris/0000-0003-1342-274X;
   Atkinson, Lou/0000-0003-1613-3791; Shea, Sue/0000-0003-0745-1085
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NR 109
TC 49
Z9 50
U1 3
U2 31
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2227-9059
J9 BIOMEDICINES
JI Biomedicines
PD NOV
PY 2021
VL 9
IS 11
AR 1697
DI 10.3390/biomedicines9111697
PG 25
WC Biochemistry & Molecular Biology; Medicine, Research & Experimental;
   Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Biochemistry & Molecular Biology; Research & Experimental Medicine;
   Pharmacology & Pharmacy
GA XG9QZ
UT WOS:000725081700001
PM 34829926
OA Green Published, Green Accepted, gold
DA 2025-06-11
ER

PT J
AU Sahin, K
   Yardimci, H
   Açik, M
   Akman, AÖ
   Yüksel, F
AF Sahin, Kezban
   Yardimci, Hulya
   Acik, Murat
   Akman, Alkim Oden
   Yuksel, Fadime
TI Association of Children's Dietary Inflammatory Index with Depression and
   Anxiety Symptoms in Adolescents: Mediating Role of Inflammation and
   Cardiometabolic Risk Factors
SO ALPHA PSYCHIATRY
LA English
DT Article
DE C-DII; depression; anxiety; inflammation; adolescents
ID METABOLIC SYNDROME; DISEASE; DII(R); HEALTH; SCORE
AB Background: Evidence is scarce on the mechanisms involved in the relationship between dietary inflammatory index and mental health in adolescents. This study aimed to assess the association between children-DII (C-DII) and depressive and anxiety disorder symptoms in adolescents and to explore whether inflammation and cardiometabolic risk factors mediate this association.Methods: The study was conducted at the Ankara City Hospital Pediatrics Polyclinic and 304 adolescents. In cross-sectional study, adolescents were asked general information questions. Anthropometric measurements were performed and some biochemical parameters and inflammation (C-reactive protein (CRP)) were obtained. The C-DII score was calculated from 24-h dietary recalls. Depression and anxiety levels of the participants were assessed by self-report. Structural equation modelling analyzed how cardiometabolic risk factors and inflammation mediate the relationship between mental health and dietary inflammation.Results: C-DII scores were positively associated with depression and anxiety score (beta [95% confidence interval (CI)] = 0.224 [0.08-0.25] for depression; 0.923 [0.04-1.67] for anxiety). Except for dietary inflammation with anxiety in girls, these relationships remained statistically significant in all subgroups by sex. It was determined that CRP partially mediated the relationship between dietary inflammation and depression and anxiety. It was determined that body mass index (BMI)-z score and waist circumference (WC) mediated the relationship between dietary inflammation and depression scores.Conclusions: Our findings indicate that the higher pro-inflammatory potential of diet is associated with a higher risk of depression and anxiety, and this association may be mediated by CRP for depression and anxiety, WC, and BMI-z score for only depression. Further research is required to verify our findings and clarify the latent mechanism in larger populations.
C1 [Sahin, Kezban] Bandirma Onyedi Eylul Univ, Fac Hlth Sci, Dept Nutr & Dietet, TR-10200 Balikesir, Turkiye.
   [Yardimci, Hulya] Ankara Univ, Fac Hlth Sci, Dept Nutr & Dietet, TR-06290 Ankara, Turkiye.
   [Acik, Murat] Firat Univ, Fac Hlth Sci, Dept Nutr & Dietet, TR-23200 Elazig, Turkiye.
   [Akman, Alkim Oden] Children Hosp, Ankara City Hosp, Dept Pediat & Adolescent Med, TR-06700 Ankara, Turkiye.
   [Yuksel, Fadime] Children Hosp, Ankara City Hosp, Dept Social Pediat, TR-06700 Ankara, Turkiye.
C3 Bandirma Onyedi Eylul University; Ankara University; Firat University;
   City Hospital Ankara; City Hospital Ankara
RP Açik, M (corresponding author), Firat Univ, Fac Hlth Sci, Dept Nutr & Dietet, TR-23200 Elazig, Turkiye.
EM macik@firat.edu.tr
RI Yardımcı, Hülya/AAF-8052-2020; Açık, Murat/ADR-4371-2022; Oden Akman,
   Alkim/AAF-4283-2021; YÜKSEL, FADİME/T-7812-2018
OI Acik, Murat/0000-0002-3104-6306; Sahin Demirci,
   Kezban/0000-0001-9278-9130
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NR 42
TC 0
Z9 0
U1 1
U2 1
PU IMR PRESS
PI ROBINSON
PA 112 ROBINSON RD, ROBINSON, SINGAPORE
EI 2757-8038
J9 ALPHA PSYCHIAT
JI Alpha Psychiat.
PD FEB 28
PY 2025
VL 26
IS 1
AR 38791
DI 10.31083/AP38791
PG 10
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychiatry
GA 2WD2O
UT WOS:001492735500018
PM 40110388
DA 2025-06-11
ER

PT J
AU Koponen, H
   Kautiainen, H
   Leppänen, E
   Mäntyselkä, P
   Vanhala, M
AF Koponen, Hannu
   Kautiainen, Hannu
   Leppanen, Esa
   Mantyselka, Pekka
   Vanhala, Mauno
TI Cardiometabolic risk factors in patients referred to depression nurse
   case managers
SO NORDIC JOURNAL OF PSYCHIATRY
LA English
DT Article
DE Beck Depression Inventory; Cardiometabolic risk factors; Depression;
   Metabolic syndrome; Suicidal behavior
ID METABOLIC SYNDROME; MAJOR DEPRESSION; SYMPTOMS; ASSOCIATION;
   CHOLESTEROL; SUICIDE; ADULTS; ANXIETY; OBESITY; HEALTH
AB Background: Disturbances in lipid and glucose metabolism are associated with depressive symptoms, and may increase suicidal behavior. Aims: To investigate the prevalence of cardiometabolic risk factors, severity of depressive symptoms, and suicidal thoughts and previous attempts in patients referred to depression nurse case managers. Methods: Blood cholesterol, triglyceride and glucose levels, depressive symptoms and suicidality were studied in 706 depressed participants and 426 controls. In addition, we compared the Beck Depression Inventory (BDI) with a diagnostic interview. Results: 448 (63%) of the patients scoring >= 10 on BDI had major depression or dysthymic disorder, 258 had an anxiety or alcohol use disorder, 137 (19%) had two or more diagnoses in the Mini-International Neuropsychiatric Interview. Suicidal thoughts (49%) and previous suicide attempts (16%) were more common in patients with depressive disorders. Patients diagnosed with depression had highest BDI scores and higher blood glucose levels measured at baseline and at 2 h in the oral glucose tolerance test (OGTT). Both patient groups also had higher triglyceride levels compared with the controls. In addition, metabolic syndrome and type 2 diabetes were most common among the depressed participants. In the whole study population, levels of low-density lipoprotein-cholesterol as well as baseline and 2-h blood glucose in OGTT were higher among patients with suicidal behavior. Conclusions: Cardiometabolic risk factors and metabolic syndrome are common in patients with depression, and in patients with anxiety and alcohol use disorders. The results imply that disturbance in glucose metabolism may be associated with suicidal thoughts and previous attempts.
C1 [Koponen, Hannu] Univ Helsinki, Inst Clin Med, Dept Psychiat, Old Age Psychiat, FIN-00014 Helsinki, Finland.
   [Koponen, Hannu] Univ Helsinki, Cent Hosp, Dept Psychiat, FIN-00014 Helsinki, Finland.
   [Kautiainen, Hannu] Kuopio Univ Hosp, Primary Hlth Care Unit, Cent Hosp Cent Finland, Primary Hlth Care Unit, Jyvaskyla, Finland.
   [Leppanen, Esa] Cent Finland Hosp Dist, Publ Util Lab KESLAB, Jyvaskyla, Finland.
   [Mantyselka, Pekka] Univ Eastern Finland, Sch Med, Inst Publ Hlth & Clin Nutr, Primary Hlth Care Unit, Joensuu, Finland.
   [Mantyselka, Pekka; Vanhala, Mauno] Kuopio Univ Hosp, Primary Hlth Care Unit, SF-70210 Kuopio, Finland.
   [Vanhala, Mauno] Univ Eastern Finland, Dept Hlth Sci, Kuopio, Finland.
   [Vanhala, Mauno] Cent Hosp Cent Finland, Primary Hlth Care Unit, Jyvaskyla, Finland.
C3 University of Helsinki; University of Helsinki; Helsinki University
   Central Hospital; Central Finland Central Hospital; Kuopio University
   Hospital; Central Finland Central Hospital; University of Eastern
   Finland; University of Eastern Finland; University of Eastern Finland
   Hospital; Kuopio University Hospital; University of Eastern Finland;
   Central Finland Central Hospital
RP Koponen, H (corresponding author), Univ Helsinki, Inst Clin Med, Dept Psychiat, Old Age Psychiat, POB 22, FIN-00014 Helsinki, Finland.
EM hannu.j.koponen@hus.fi
OI Koponen, Hannu/0000-0002-7368-1869
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NR 43
TC 11
Z9 11
U1 0
U2 5
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0803-9488
EI 1502-4725
J9 NORD J PSYCHIAT
JI Nord. J. Psychiatr.
PD MAY
PY 2015
VL 69
IS 4
BP 262
EP 267
DI 10.3109/08039488.2014.972451
PG 6
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA CH9YG
UT WOS:000354392000004
PM 25363212
DA 2025-06-11
ER

PT J
AU Forte, G
   Favieri, F
   Pazzaglia, M
   Casagrande, M
AF Forte, Giuseppe
   Favieri, Francesca
   Pazzaglia, Mariella
   Casagrande, Maria
TI Mental and Body Health: The Association between Psychological Factors,
   Overweight, and Blood Pressure in Young Adults
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Article
DE cardiometabolic risk factors; blood pressure; weight condition;
   depression; anxiety; emotional dysregulation
ID PSYCHIATRIC-DISORDERS; NEUROPEPTIDE-Y; DEPRESSION; ANXIETY; OBESITY;
   HYPERTENSION; RISK; ALEXITHYMIA; METAANALYSIS; INCREASES
AB Comorbidity between cardiometabolic risk factors and major mental health disorders is a public health concern. The close interconnection between the mental and physical aspects of health precludes considering each condition separately. Accordingly, this study sought to explore the interrelationships between psychological factors, overweight, and blood pressure in young adults. One hundred and forty-five young adults participated in the study and were classified according to two independent characteristics: weight condition (normal weight, overweight) and blood pressure (low blood pressure, high blood pressure). Anxiety, depression, and emotional dysregulation were assessed. The results confirmed certain associations, highlighting how cardiometabolic risk factors, such as blood pressure and body mass index, were associated in different ways with mental health, although an interaction between the variables was not reported. In particular, a relationship between body mass index and depression and between anxiety and blood pressure was detected.
C1 [Forte, Giuseppe; Favieri, Francesca; Pazzaglia, Mariella] Sapienza Univ Rome, Dept Psychol, Via Marsi 78, I-00185 Rome, Italy.
   [Forte, Giuseppe; Favieri, Francesca; Pazzaglia, Mariella] IRCCS Santa Lucia Fdn, Body & Act Lab, Via Ardeatina 306, I-00179 Rome, Italy.
   [Casagrande, Maria] Sapienza Univ Rome, Dept Dynam & Clin Psychol & Hlth Studies, I-00185 Rome, Italy.
C3 Sapienza University Rome; IRCCS Santa Lucia; Sapienza University Rome
RP Forte, G (corresponding author), Sapienza Univ Rome, Dept Psychol, Via Marsi 78, I-00185 Rome, Italy.; Forte, G (corresponding author), IRCCS Santa Lucia Fdn, Body & Act Lab, Via Ardeatina 306, I-00179 Rome, Italy.
EM g.forte@uniroma1.it; francesca.favieri@uniroma1.it;
   mariella.pazzaglia@uniroma1.it; maria.casagrande@uniroma1.it
RI Pazzaglia, Mariella/C-9388-2011; Casagrande, Maria/ABD-7234-2020;
   FAVIERI, FRANCESCA/C-5056-2019; FORTE, GIUSEPPE/C-5055-2019
OI Pazzaglia, Mariella/0000-0002-9196-7078; Casagrande,
   Maria/0000-0002-4430-3367; FAVIERI, FRANCESCA/0000-0002-6696-5855;
   FORTE, GIUSEPPE/0000-0002-5223-041X
FU Italian Ministry of Health [RF-2018-12365682]
FX This research was funded by the Italian Ministry of Health, grant number
   RF-2018-12365682.
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NR 63
TC 7
Z9 8
U1 0
U2 18
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD APR
PY 2022
VL 11
IS 7
AR 1999
DI 10.3390/jcm11071999
PG 10
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA 0M3WE
UT WOS:000782087800001
PM 35407607
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Bleil, ME
   Bromberger, JT
   Latham, MD
   Adler, NE
   Pasch, LA
   Gregorich, SE
   Rosen, MP
   Cedars, MI
AF Bleil, Maria E.
   Bromberger, Joyce T.
   Latham, Melissa D.
   Adler, Nancy E.
   Pasch, Lauri A.
   Gregorich, Steven E.
   Rosen, Mitchell P.
   Cedars, Marcelle I.
TI Disruptions in ovarian function are related to depression and
   cardiometabolic risk during premenopause
SO MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY
LA English
DT Article
DE Ovarian function; Menstrual cycle length; Depression; Cardiovascular
   risk; Cardiometabolic risk; Metabolic syndrome
ID ANTI-MULLERIAN HORMONE; CORONARY-HEART-DISEASE; MENSTRUAL-CYCLE
   CHARACTERISTICS; WOMEN APPROACHING MENOPAUSE; ACUTE
   MYOCARDIAL-INFARCTION; OF-THE-LITERATURE; METABOLIC SYNDROME;
   CARDIOVASCULAR-DISEASE; NATURAL MENOPAUSE; YOUNG-ADULTS
AB Objective: The aim of this study was to evaluate the extent to which mild disruptions in ovarian function, indexed by changes in menstrual cycle length, may relate to cardiometabolic and psychological health in premenopausal women.
   Methods: Among 804 healthy, regularly cycling women (aged 25-45 y; mean [SD] age, 35.5 [5.5] y), patterns of any change (shortening, lengthening, or increased variability) versus no change in menstrual cycle length were examined in relation to a composite of cardiometabolic risk and individual risk factors (high-density lipoprotein, triglycerides, waist circumference, glucose, and hypertensive status), as well as in relation to depression indicators (Center for Epidemiological Studies Depression Scale score >= 16 [yes/no], lifetime depression diagnosis [yes/no], and lifetime antidepressant medication use [yes/no]). Models were also explored to test whether changes in menstrual cycle length mediated relations between depression history and cardiometabolic risk.
   Results: In covariate-adjusted models compared with no change, any change in menstrual cycle length was associated with higher cardiometabolic risk composite scores and lower high-density lipoprotein (P < 0.05). In addition, compared with no change, any change in menstrual cycle length was associated with a Center for Epidemiological Studies Depression Scale score of 16 or higher, having received a depression diagnosis, and having used antidepressant medications (P < 0.05). In exploratory analyses, any change in menstrual cycle length partially mediated the relation between depression history and cardiometabolic risk (b = 0.152, P = 0.040), which attenuated (b = 0.129, P = 0.083) when any change in menstrual cycle length was covaried.
   Conclusions: Findings suggest that disruptions in ovarian function, marked by subtle changes in menstrual cycle length, may relate to aspects of cardiometabolic and psychological health among healthy, premenopausal women.
C1 [Bleil, Maria E.; Latham, Melissa D.; Adler, Nancy E.; Pasch, Lauri A.] Univ Calif San Francisco, Dept Psychiat, San Francisco, CA 94143 USA.
   [Bromberger, Joyce T.] Univ Pittsburgh, Dept Epidemiol, Pittsburgh, PA 15261 USA.
   [Gregorich, Steven E.] Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA.
   [Rosen, Mitchell P.; Cedars, Marcelle I.] Univ Calif San Francisco, Dept Obstet Gynecol & Reprod Sci, San Francisco, CA 94143 USA.
C3 University of California System; University of California San Francisco;
   Pennsylvania Commonwealth System of Higher Education (PCSHE); University
   of Pittsburgh; University of California System; University of California
   San Francisco; University of California System; University of California
   San Francisco
RP Bleil, ME (corresponding author), Univ Calif San Francisco, Suite 465,3333 Calif St, San Francisco, CA 94143 USA.
EM maria.bleil@ucsf.edu
RI Adler, Nancy/ABR-3334-2022
OI bromberger, joyce/0000-0001-7101-3800
FU National Institutes of Health (NIH)/National Institute of Child Health
   and Human Development and NIH/National Institute on Aging [R01
   HD044876]; NIH/National Institute on Aging [K08 AG03575]; NIH/University
   of California San Francisco Clinical and Translational Science Institute
   [UL1 RR024131]; Brain and Behavior Research Foundation; Robert Wood
   Johnson Foundation [045820]
FX Preparation of this manuscript and the research described here were
   supported by the National Institutes of Health (NIH)/National Institute
   of Child Health and Human Development and NIH/National Institute on
   Aging (R01 HD044876), NIH/National Institute on Aging (K08 AG03575),
   NIH/University of California San Francisco Clinical and Translational
   Science Institute (UL1 RR024131), the Brain and Behavior Research
   Foundation, and the Robert Wood Johnson Foundation (045820).
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NR 89
TC 20
Z9 21
U1 0
U2 7
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1072-3714
EI 1530-0374
J9 MENOPAUSE
JI Menopause-J. N. Am. Menopause Soc.
PD JUN
PY 2013
VL 20
IS 6
BP 631
EP 639
DI 10.1097/gme.0b013e31827c5c45
PG 9
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA 154GC
UT WOS:000319659300008
PM 23715377
OA Green Accepted, Green Submitted
DA 2025-06-11
ER

PT J
AU Shea, S
   Lionis, C
   Kite, C
   Lagojda, L
   Uthman, OA
   Dallaway, A
   Atkinson, L
   Chaggar, SS
   Randeva, HS
   Kyrou, I
AF Shea, Sue
   Lionis, Christos
   Kite, Chris
   Lagojda, Lukasz
   Uthman, Olalekan A.
   Dallaway, Alexander
   Atkinson, Lou
   Chaggar, Surinderjeet S.
   Randeva, Harpal S.
   Kyrou, Ioannis
TI Non-alcoholic fatty liver disease and coexisting depression, anxiety
   and/or stress in adults: a systematic review and meta-analysis
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Article
DE non-alcoholic fatty liver disease; NAFLD; NASH; mental health;
   depression; anxiety; stress
ID QUALITY-OF-LIFE; HETEROGENEITY; ASSOCIATION; POPULATION; SEVERITY;
   BURDEN; BIAS
AB Background Non-alcoholic fatty liver disease (NAFLD) is a common chronic liver disease, affecting 25-30% of the general population globally. The condition is even more prevalent in individuals with obesity and is frequently linked to the metabolic syndrome. Given the known associations between the metabolic syndrome and common mental health issues, it is likely that such a relationship also exists between NAFLD and mental health problems. However, studies in this field remain limited. Accordingly, the aim of this systematic review and meta-analysis was to explore the prevalence of one or more common mental health conditions (i.e., depression, anxiety, and/or stress) in adults with NAFLD. Methods PubMed, EBSCOhost, ProQuest, Ovid, Web of Science, and Scopus were searched in order to identify studies reporting the prevalence of depression, anxiety, and/or stress among adults with NAFLD. A random-effects model was utilized to calculate the pooled prevalence and confidence intervals for depression, anxiety and stress. Results In total, 31 studies were eligible for inclusion, involving 2,126,593 adults with NAFLD. Meta-analyses yielded a pooled prevalence of 26.3% (95% CI: 19.2 to 34) for depression, 37.2% (95% CI: 21.6 to 54.3%) for anxiety, and 51.4% (95% CI: 5.5 to 95.8%) for stress among adults with NAFLD. Conclusion The present findings suggest a high prevalence of mental health morbidity among adults with NAFLD. Given the related public health impact, this finding should prompt further research to investigate such associations and elucidate potential associations between NAFLD and mental health morbidity, exploring potential shared underlying pathophysiologic mechanisms. Systematic review registration https://www.crd.york.ac.uk/prospero/, identifier CRD42021288934.
C1 [Shea, Sue; Atkinson, Lou; Randeva, Harpal S.; Kyrou, Ioannis] Univ Warwick, Warwick Med Sch, Coventry, England.
   [Shea, Sue; Kite, Chris; Lagojda, Lukasz; Dallaway, Alexander; Atkinson, Lou; Randeva, Harpal S.; Kyrou, Ioannis] Univ Hosp Coventry & Warwickshire NHS Trust, Warwickshire Inst Study Diabet Endocrinol & Metab, Coventry, England.
   [Lionis, Christos] Univ Crete, Lab Hlth & Sci, Sch Med, Iraklion, Greece.
   [Lionis, Christos] Univ Linkoping, Dept Hlth Med & Caring Sci, Linkoping, Sweden.
   [Lionis, Christos] Frederick Univ, Dept Nursing, Nicosia, Cyprus.
   [Kite, Chris; Dallaway, Alexander] Univ Wolverhampton, Fac Educ Hlth & Wellbeing, Sch Hlth & Soc, Wolverhampton, England.
   [Kite, Chris] Univ Chester, Chester Med Sch, Shrewsbury, England.
   [Kite, Chris; Randeva, Harpal S.; Kyrou, Ioannis] Coventry Univ, Res Inst Hlth & Wellbeing, Ctr Sport Exercise & Life Sci, Coventry, England.
   [Lagojda, Lukasz] Univ Hosp Coventry & Warwickshire NHS Trust, Clin Evidence Based Informat Serv CEBIS, Coventry, England.
   [Uthman, Olalekan A.] Univ Warwick, Warwick Ctr Global Hlth, Warwick Med Sch, Div Hlth Sci, Coventry, England.
   [Atkinson, Lou] iPrescribe Exercise Digital Ltd EXI, London, England.
   [Chaggar, Surinderjeet S.] Sowe Valley Primary Care Network, Forum Hlth Ctr, Coventry, England.
   [Randeva, Harpal S.; Kyrou, Ioannis] Univ Hosp Coventry & Warwickshire NHS Trust, Inst Cardiometab Med, Coventry, England.
   [Kyrou, Ioannis] Aston Univ, Coll Hlth & Life Sci, Aston Med Sch, Birmingham, England.
   [Kyrou, Ioannis] Univ Derby, Coll Hlth Psychol & Social Care, Derby, England.
   [Kyrou, Ioannis] Agr Univ Athens, Sch Food & Nutr Sci, Dept Food Sci & Human Nutr, Lab Dietet & Qual Life, Athens, Greece.
C3 University of Warwick; University of Warwick; University of Crete;
   Linkoping University; University of Wolverhampton; Coventry University;
   University of Warwick; University of Warwick; University of Warwick;
   Aston University; University of Derby; Agricultural University of Athens
RP Randeva, HS; Kyrou, I (corresponding author), Univ Warwick, Warwick Med Sch, Coventry, England.; Randeva, HS; Kyrou, I (corresponding author), Univ Hosp Coventry & Warwickshire NHS Trust, Warwickshire Inst Study Diabet Endocrinol & Metab, Coventry, England.; Randeva, HS; Kyrou, I (corresponding author), Coventry Univ, Res Inst Hlth & Wellbeing, Ctr Sport Exercise & Life Sci, Coventry, England.; Randeva, HS; Kyrou, I (corresponding author), Univ Hosp Coventry & Warwickshire NHS Trust, Inst Cardiometab Med, Coventry, England.; Kyrou, I (corresponding author), Aston Univ, Coll Hlth & Life Sci, Aston Med Sch, Birmingham, England.; Kyrou, I (corresponding author), Univ Derby, Coll Hlth Psychol & Social Care, Derby, England.; Kyrou, I (corresponding author), Agr Univ Athens, Sch Food & Nutr Sci, Dept Food Sci & Human Nutr, Lab Dietet & Qual Life, Athens, Greece.
EM harpal.randeva@uhcw.nhs.uk; kyrouj@gmail.com
RI Uthman, Olalekan/N-5584-2019; Lionis, Christos/MBV-1499-2025; Lagojda,
   Lukasz/HCH-7750-2022
OI Lagojda, Lukasz/0000-0001-9793-3672; Shea, Sue/0000-0003-0745-1085
FU University Hospitals Coventry and Warwickshire (UHCW) NHS Trust; General
   Charities of Coventry
FX SS, IK, and HR would like to thank the University Hospitals Coventry and
   Warwickshire (UHCW) NHS Trust and the General Charities of Coventry for
   their ongoing support.
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NR 94
TC 12
Z9 12
U1 1
U2 5
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD APR 16
PY 2024
VL 15
AR 1357664
DI 10.3389/fendo.2024.1357664
PG 16
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA OT9Y6
UT WOS:001209662900001
PM 38689730
OA Green Accepted, gold, Green Published
DA 2025-06-11
ER

PT J
AU Bhandari, P
   Paswan, B
AF Bhandari, Pravat
   Paswan, Balram
TI Lifestyle Behaviours and Mental Health Outcomes of Elderly: Modification
   of Socio-Economic and Physical Health Effects
SO AGEING INTERNATIONAL
LA English
DT Article
DE Lifestyle; Elderly; Anxiety; Depression; Path analysis; Moderation
   analysis
ID EXPLORATORY FACTOR-ANALYSIS; COEFFICIENT-ALPHA; OLDER-ADULTS; METABOLIC
   SYNDROME; DEPRESSION; ASSOCIATION; DISEASE; DISABILITY; ILLNESS; RISK
AB Lifestyle behaviours and its mediating relationships between socio-economic characteristics and physical health effects have been widely discussed in epidemiological study. Considering a proper study framework, the relationship between lifestyle and mental health has not been rigorously established. Utilizing population based elderly data fromBuilding a Knowledge Base on Population Ageing in India (BKPAI), present study has made an attempt to understand the direct and indirect effects of lifestyle behaviours on the mental health outcomes of elderly through statistical path. Six lifestyle behaviours were examined: physical activity, smoking, alcohol consumption, diet, family relation and social activity. In order to measure mental health, two common symptoms of general psychological stress including anxiety and depression were identified by examining factor structure of twelve item General Health Questionnaire (GHQ-12) in Indian elderly. The result shows that anxiety and depression were more common among the elderly with unhealthy lifestyle such as physical inactivity, regular smoking, social isolation and poor family relation. Multivariate analysis also shows, poor physical health, characterised by functional limitation, presence of NCDs, and disability has a stronger influence on anxiety and depression. Moderation analysis suggests that both physical activity and social activity have a moderation effect on anxiety and depression over socio-economic risk factors. This study evidently concludes that unhealthy lifestyle behaviours of older adults such as regular smoking, low level of physical activity are directly vis-a-vis indirectly associated with bad mental health. Therefore, modification of these unhealthy lifestyle behaviours will effectively reduce the burden of psychological distress among older adults in India.
C1 [Bhandari, Pravat] Int Inst Populat Sci, Dept Populat Studies, Mumbai 400088, Maharashtra, India.
   [Paswan, Balram] Int Inst Populat Sci, Dept Populat Policies & Programmes, Mumbai 400088, Maharashtra, India.
C3 International Institute for Population Sciences; International Institute
   for Population Sciences
RP Bhandari, P (corresponding author), Int Inst Populat Sci, Dept Populat Studies, Mumbai 400088, Maharashtra, India.
EM pravat784@gmail.com
RI Bhandari, Pravat/AAW-6214-2021
OI Bhandari, Pravat/0000-0002-9422-8094
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NR 90
TC 23
Z9 25
U1 2
U2 23
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0163-5158
EI 1936-606X
J9 AGEING INT
JI Ageing Int.
PD MAR
PY 2021
VL 46
IS 1
BP 35
EP 69
DI 10.1007/s12126-020-09371-0
EA MAR 2020
PG 35
WC Gerontology
WE Emerging Sources Citation Index (ESCI)
SC Geriatrics & Gerontology
GA QR3QW
UT WOS:000563162900001
DA 2025-06-11
ER

PT J
AU Cho, S
   Park, M
AF Cho, Sinyoung
   Park, Minseon
TI Gender Difference in the Impact of Total Energy Intake on the
   Association between Low Fiber Intake and Mental Health in Middle-Aged
   and Older Adults
SO NUTRIENTS
LA English
DT Article
DE dietary fibers; psychological stress; psychological distress;
   depression; subjective health; mental health
ID DIETARY FIBER; DEPRESSIVE SYMPTOMS; METABOLIC SYNDROME;
   PHYSICAL-ACTIVITY; SKELETAL-MUSCLE; CONSUMPTION; PREVALENCE; NUTRITION;
   DISEASE; ANXIETY
AB The effect of dietary fiber intake on mental health is controversial. This study aimed to examine the association of fiber intake with mental health in Korean adults. This cross-sectional study included 11,288 participants aged >= 40 years who participated in the Korean Genome and Epidemiology Study (2004-2013). Fiber intake was assessed using a food frequency questionnaire and categorized into sex-specific quintiles. Multiple logistic regression models were used to investigate the association between the lowest quintile of fiber intake and poor mental health. Mental health was assessed using acute stress perception, the Psychosocial Well-Being Index-Short Form, self-rated health, and the Center for Epidemiological Studies-Depression Scale in Korea. Compared to those with higher fiber intake, having the lowest quintile of fiber intake was associated with higher odds of poor mental health risk, a higher risk of high-stress perception, poor psychosocial distress in males, poor psychosocial distress, and depression in females. Low fiber intake had profound negative mental health effects on males with high total energy intake and females with low total energy intake. In conclusion, there is a gender difference in the impact of total energy intake on the deleterious effect of low fiber intake on mental health.
C1 [Cho, Sinyoung; Park, Minseon] Seoul Natl Univ Hosp, Dept Family Med, 101 Daehakro, Seoul 03080, South Korea.
   [Cho, Sinyoung] Seoul Natl Univ, Coll Med, Dept Prevent Med, 103 Daehakro, Seoul 03080, South Korea.
   [Park, Minseon] Seoul Natl Univ, Coll Med, Dept Family Med, 103 Daehakro, Seoul 03080, South Korea.
C3 Seoul National University (SNU); Seoul National University Hospital;
   Seoul National University (SNU); Seoul National University (SNU)
RP Park, M (corresponding author), Seoul Natl Univ Hosp, Dept Family Med, 101 Daehakro, Seoul 03080, South Korea.; Park, M (corresponding author), Seoul Natl Univ, Coll Med, Dept Family Med, 103 Daehakro, Seoul 03080, South Korea.
EM sinyoungcho@snu.ac.kr; pdragon5@snu.ac.kr
OI Cho, Sinyoung/0009-0000-7991-3715; Park, Minseon/0000-0001-6120-8356
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NR 48
TC 0
Z9 0
U1 3
U2 6
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD AUG
PY 2024
VL 16
IS 16
AR 2583
DI 10.3390/nu16162583
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA E7N1C
UT WOS:001304825100001
PM 39203720
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Kobrosly, RW
   van Wijngaarden, E
AF Kobrosly, Roni W.
   van Wijngaarden, Edwin
TI Revisiting the Association Between Metabolic Syndrome and Depressive
   Symptoms
SO ANNALS OF EPIDEMIOLOGY
LA English
DT Article
DE Depression; Metabolic Syndrome X; Epidemiology; Cross-Sectional Studies;
   Psychosomatic Medicine
ID NUTRITION EXAMINATION SURVEY; 3RD NATIONAL-HEALTH; MAJOR DEPRESSION;
   UNITED-STATES; ADULTS; RISK; PATHOPHYSIOLOGY; ANXIETY; ONSET;
   METAANALYSIS
C1 [Kobrosly, Roni W.] Univ Rochester, Dept Community & Prevent Med, Sch Med & Dent, Med Ctr, Rochester, NY 14642 USA.
C3 University of Rochester
RP Kobrosly, RW (corresponding author), Univ Rochester, Dept Community & Prevent Med, Sch Med & Dent, Med Ctr, 601 Elmwood Ave,Box 644, Rochester, NY 14642 USA.
EM Roni_Kobrosly@URMC.Rochester.edu
RI van Wijngaarden, Edwin/Q-2073-2019
OI van Wijngaarden, Edwin/0000-0001-7583-4630; Kobrosly,
   Roni/0000-0003-0363-9662
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NR 44
TC 5
Z9 7
U1 0
U2 2
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1047-2797
J9 ANN EPIDEMIOL
JI Ann. Epidemiol.
PD NOV
PY 2010
VL 20
IS 11
BP 852
EP 855
DI 10.1016/j.annepidem.2010.08.002
PG 4
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA 673QY
UT WOS:000283679300008
PM 20933192
DA 2025-06-11
ER

PT J
AU Levine, AB
   Levine, LM
   Levine, TB
AF Levine, Arlene Bradley
   Levine, Lionel M.
   Levine, T. Barry
TI Posttraumatic Stress Disorder and Cardiometabolic Disease
SO CARDIOLOGY
LA English
DT Article
DE Cardiovascular disease; Hypothalamic-pituitary-adrenal axis;
   Inflammation; Insulin resistance; Metabolism; Sympathetic nervous system
ID HEART-RATE-VARIABILITY; PITUITARY-ADRENAL AXIS; NEUROPEPTIDE-Y NPY;
   METABOLIC SYNDROME; CARDIOVASCULAR-DISEASE; MYOCARDIAL-INFARCTION;
   TRAUMATIC STRESS; COMBAT VETERANS; WAR VETERANS; PSYCHOLOGICAL STRESS
AB The need for addressing posttraumatic stress disorder (PTSD) among combat veterans returning from Afghanistan and Iraq is a growing public health concern. Current PTSD management addresses psychiatric parameters of this condition. However, PTSD is not simply a psychiatric disorder. Traumatic stress increases the risk for inflammation-related somatic diseases and early mortality. The metabolic syndrome reflects the increased health risk associated with combat stress and PTSD. Obesity, dyslipidemia, hypertension, diabetes mellitus, and cardiovascular disease are prevalent among PTSD patients. However, there has been little appreciation for the need to address these somatic PTSD comorbidities. Medical professionals treating this vulnerable population should screen patients for cardiometabolic risk factors and avail themselves of existing preventive diet, exercise, and pharmacologic modalities that will reduce such risk factors and improve overall long-term health outcomes and quality of life. There is the promise that cardiometabolic preventive therapy complementing psychiatric intervention may, in turn, help improve the posttraumatic stress system dysregulation and favorably impact psychiatric and neurologic function. (C) 2013 S. Karger AG, Basel
C1 [Levine, Arlene Bradley; Levine, T. Barry] ABLE Med Consulting, Pittsburgh, PA 15217 USA.
   [Levine, Lionel M.] Mitre Corp, Ctr Transforming Hlth, Ctr Vet Enterprise Transformat, Bedford, MA 01730 USA.
C3 MITRE Corporation
RP Levine, TB (corresponding author), ABLE Med Consulting, 5622 Bartlett St, Pittsburgh, PA 15217 USA.
EM TBLevine6000@yahoo.com
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NR 193
TC 108
Z9 118
U1 0
U2 34
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0008-6312
EI 1421-9751
J9 CARDIOLOGY
JI Cardiology
PY 2014
VL 127
IS 1
BP 1
EP 19
DI 10.1159/000354910
PG 19
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 269JV
UT WOS:000328238500001
PM 24157651
OA Bronze
DA 2025-06-11
ER

PT J
AU Aldridge, E
   Schubert, KO
   Pathirana, M
   Sierp, S
   Leemaqz, SY
   Roberts, CT
   Dekker, GA
   Arstall, MA
AF Aldridge, Emily
   Schubert, K. Oliver
   Pathirana, Maleesa
   Sierp, Susan
   Leemaqz, Shalem Y.
   Roberts, Claire T.
   Dekker, Gustaaf A.
   Arstall, Margaret A.
TI A prospective registry analysis of psychosocial and metabolic health
   between women with and without metabolic syndrome after a complicated
   pregnancy
SO BMC WOMENS HEALTH
LA English
DT Article
DE Maternal health; Metabolic syndrome; Pregnancy complications; Maternal
   mental health
ID SOCIOECONOMIC-STATUS; CARDIOVASCULAR-DISEASE; DEPRESSION; ANXIETY; RISK;
   ASSOCIATION; METAANALYSIS; EXPERIENCES; OBESITY; BIRTH
AB Purpose Pregnancy complications affect over one quarter of Australian pregnancies, and this group of mothers is vulnerable and more likely to experience adverse cardiometabolic health outcomes in the postpartum period. Metabolic syndrome is common in this population and may be associated with postpartum mental health issues. However, this relationship remains poorly understood. To compare the differences in psychosocial parameters and mental health outcomes between women with metabolic syndrome and women without metabolic syndrome 6 months after a complicated pregnancy. Methods This study is prospective registry analysis of women attending a postpartum healthy lifestyle clinic 6 months following a complicated pregnancy. Mental health measures included 9-item Patient Health Questionnaire (PHQ-9), 7-item Generalised Anxiety Disorder questionnaire (GAD-7), self-reported diagnosed history of depression, anxiety and/or other psychiatric condition, and current psychotropic medication use. Results Women with metabolic syndrome reported significantly more subjective mental health concerns, were more likely to have a history of depression and other psychiatric diagnoses and were more likely prescribed psychotropic medications. However, there were no significant differences in PHQ-9 and GAD-7 scores. Conclusion Amongst new mothers who experienced complications of pregnancy, those with metabolic syndrome represent a particularly vulnerable group with regards to psychosocial disadvantage and mental health outcomes. These vulnerabilities may not be apparent when using common standardised cross-sectional mental health screening tools such as PHQ-9 and GAD-7.
C1 [Aldridge, Emily; Schubert, K. Oliver; Pathirana, Maleesa; Roberts, Claire T.; Dekker, Gustaaf A.; Arstall, Margaret A.] Univ Adelaide, Adelaide Med Sch, Adelaide, SA, Australia.
   [Aldridge, Emily; Pathirana, Maleesa; Roberts, Claire T.; Dekker, Gustaaf A.] Univ Adelaide, Robinson Res Inst, Adelaide, SA, Australia.
   [Aldridge, Emily; Sierp, Susan; Arstall, Margaret A.] Northern Adelaide Local Hlth Network, Dept Cardiol, Elizabeth Vale, SA, Australia.
   [Schubert, K. Oliver] Northern Adelaide Local Hlth Network, Div Mental Hlth, Elizabeth Vale, SA, Australia.
   [Schubert, K. Oliver] Sonder, Headspace Early Psychosis, Adelaide, SA, Australia.
   [Leemaqz, Shalem Y.; Roberts, Claire T.] Flinders Univ S Australia, Flinders Hlth & Med Res Inst, Bedford Pk, SA, Australia.
   [Dekker, Gustaaf A.] Northern Adelaide Local Hlth Network, Dept Obstet & Gynaecol, Elizabeth Vale, SA, Australia.
C3 University of Adelaide; Robinson Research Institute; University of
   Adelaide; Flinders University South Australia
RP Aldridge, E (corresponding author), Univ Adelaide, Adelaide Med Sch, Adelaide, SA, Australia.; Aldridge, E (corresponding author), Univ Adelaide, Robinson Res Inst, Adelaide, SA, Australia.; Aldridge, E (corresponding author), Northern Adelaide Local Hlth Network, Dept Cardiol, Elizabeth Vale, SA, Australia.
EM emily.aldridge@adelaide.edu.au
RI Schubert, Oliver/AGX-9412-2022; Roberts, Claire/A-1205-2007
OI Arstall, Margaret/0000-0003-0760-6382; Schubert, Klaus
   Oliver/0000-0003-1690-0209; Leemaqz, Shalem/0000-0003-4616-8426;
   Roberts, Claire/0000-0002-9250-2192; Pathirana,
   Maleesa/0000-0002-5817-4156
FU Hospital Research Foundation [2018/006-QA25232]; NHMRC Investigator
   Grant [GNT1174971]; Matthew Flinders Fellowship from Flinders University
FX This study received no specific funding. EA was supported by PhD
   Fellowship from The Hospital Research Foundation (Grant ID:
   2018/006-QA25232). CTR was supported by an NHMRC Investigator Grant
   (Grant ID: GNT1174971) and a Matthew Flinders Fellowship from Flinders
   University.
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NR 55
TC 1
Z9 2
U1 0
U2 0
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1472-6874
J9 BMC WOMENS HEALTH
JI BMC Womens Health
PD NOV 21
PY 2022
VL 22
IS 1
AR 461
DI 10.1186/s12905-022-02035-y
PG 9
WC Public, Environmental & Occupational Health; Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; Obstetrics & Gynecology
GA 6I7SD
UT WOS:000886331800003
PM 36404332
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Vicente-Herrero, T
   Soler, MG
   Agudo, SG
   Vallejos, D
   López-González, AA
   Ramírez-Manent, JI
AF Vicente-Herrero, Teofila
   Soler, Maria Gordito
   Agudo, Sheila Garcia
   Vallejos, Daniela
   Lopez-Gonzalez, angel Arturo
   Ramirez-Manent, Jose Ignacio
TI Cardiometabolic risk level in 1136 Spanish professional musicians
SO MEDICINA BALEAR
LA English
DT Article
DE Musicians; cardiometabolic risk; obesity; dyslipidemia; metabolic
   syndrome; insulin resistance
ID HEARING-LOSS; DEPRESSION; ANXIETY
AB Introduction: Practically all the studies carried out on musicians have focused on musculoskeletal and mental injuries. The aim of this study is to determine the level of cardiometabolic risk in this group of workers. Methodology: Descriptive and cross-sectional study in 1136 Spanish professional musicians in which the level of cardiometabolic risk (obesity, hypertension, dyslipidemia, insulin resistance, atherogenic risk, metabolic syndrome and heart age) was determined. Results: The mean age of the musicians was 35 years and the cardiometabolic risk was moderate, with a high prevalence of obesity and especially dyslipidemia. Conclusions: Taking into account the age of the participants and that they show a moderate level of risk, it is advisable to carry out health promotion activities in the group of musicians.
C1 [Vicente-Herrero, Teofila; Vallejos, Daniela; Lopez-Gonzalez, angel Arturo; Ramirez-Manent, Jose Ignacio] Univ Inst Res Hlth Sci IUNICS, Invest Grp ADEMA SALUD, Palma De Mallorca, Balearic Island, Spain.
   [Soler, Maria Gordito] Pharmaceut, Seville, Spain.
   [Agudo, Sheila Garcia] Madrid Hlth Serv, Primary Care Assistance Management, Madrid, Spain.
C3 Universitat de les Illes Balears; IUNICS
RP Ramírez-Manent, JI (corresponding author), Univ Inst Res Hlth Sci IUNICS, Invest Grp ADEMA SALUD, Palma De Mallorca, Balearic Island, Spain.
OI Ramirez Manent, Jose Ignacio/0000-0001-6887-4562
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NR 42
TC 3
Z9 3
U1 2
U2 2
PU REIAL ACAD MEDICINA ILLES BALEARS
PI PALMA DE MALLORCA
PA CALLE COMPANER 4, PALMA DE MALLORCA, 07003, SPAIN
SN 1579-5853
EI 2255-0569
J9 MED BALEAR
JI Med. Balear
PD SEP-OCT
PY 2024
VL 39
IS 5
DI 10.3306/AJHS.2024.39.05.59
PG 182
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA K3T2T
UT WOS:001343128500007
DA 2025-06-11
ER

PT J
AU Dunbar, JA
   Reddy, P
   Davis-Lameloise, N
   Philpot, B
   Laatikainen, T
   Kilkkinen, A
   Bunker, SJ
   Best, JD
   Vartiainen, E
   Lo, SK
   Janus, ED
AF Dunbar, James A.
   Reddy, Prasuna
   Davis-Lameloise, Nathalie
   Philpot, Benjamin
   Laatikainen, Tiina
   Kilkkinen, Annamari
   Bunker, Stephen J.
   Best, James D.
   Vartiainen, Erkki
   Lo, Sing Kai
   Janus, Edward D.
TI Depression: An Important Comorbidity With Metabolic Syndrome in a
   General Population
SO DIABETES CARE
LA English
DT Article
ID YOUNG-ADULTS; OBESITY; INFLAMMATION; SYMPTOMS; ANXIETY; HEALTH; WOMEN;
   HEART; RISK
AB OBJECTIVE - There is a recognized association among depression, diabetes, and cardiovascular disease. The aim of this study was to examine in a sample representative of the general population whether depression, anxiety, and psychological distress are associated with metabolic syndrome and its components.
   RESEARCH DESIGN AND METHODS - Three cross-sectional surveys including clinical health measures were completed in rural regions of Australia during 2004-2006. A stratified random sample (n = 1,690, response rate 48%) of men and women aged 25-84 years was selected from the electoral roll. Metabolic syndrome was defined by the Third Report of the National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults, Adult Treatment Panel III (NCEP ATP III), and International Diabetes Federation (IDF) criteria. Anxiety and depression were assessed by the Hospital Anxiety and Depression Scale and psychological distress by the Kessler 10 measure.
   RESULTS - Metabolic syndrome was associated with depression but not psychological stress or anxiety. Participants with the metabolic syndrome had higher scores for depression (n = 409, mean score 3.41, 95% CI 3.12-3.70) than individuals without the metabolic syndrome (n = 936, mean 2.95, 95% CI 2.76-3.13). This association was also present in 338 participants with the metabolic syndrome and without diabetes (mean score 3.37, 95% CI 3.06-3.68). Large waist circumference and low HDL cholesterol showed significant and independent associations with depression.
   CONCLUSIONS - Our results show an association between metabolic syndrome and depression in a heterogeneous sample. The presence of depression in individuals with the metabolic syndrome has implications for clinical management.
C1 [Dunbar, James A.; Reddy, Prasuna; Davis-Lameloise, Nathalie; Philpot, Benjamin; Laatikainen, Tiina; Kilkkinen, Annamari; Bunker, Stephen J.; Janus, Edward D.] Flinders Univ S Australia, Dept Rural Hlth, Greater Green Triangle Univ, Warrnambool, Vic, Australia.
   [Dunbar, James A.; Reddy, Prasuna; Davis-Lameloise, Nathalie; Philpot, Benjamin; Laatikainen, Tiina; Kilkkinen, Annamari; Bunker, Stephen J.; Janus, Edward D.] Deakin Univ, Warrnambool, Vic, Australia.
   [Laatikainen, Tiina; Kilkkinen, Annamari; Vartiainen, Erkki] Natl Publ Hlth Inst, Helsinki, Finland.
   [Janus, Edward D.] Univ Melbourne, Dept Med, Melbourne, Vic, Australia.
   [Best, James D.] Univ Melbourne, Dept Med, St Vincent Hosp, Melbourne, Vic, Australia.
   [Lo, Sing Kai] Deakin Univ, Fac Hlth Med Nursing & Behav Sci, Melbourne, Vic, Australia.
C3 Flinders University South Australia; Deakin University; Deakin
   University; Finland National Institute for Health & Welfare; University
   of Melbourne; St Vincent's Health; St Vincent's Hospital Melbourne;
   University of Melbourne; Deakin University
RP Dunbar, JA (corresponding author), Flinders Univ S Australia, Dept Rural Hlth, Greater Green Triangle Univ, Warrnambool, Vic, Australia.
EM director@greaterhealth.org
RI Lo, Sing/MEP-1379-2025; Dunbar, James/G-3034-2012; Laatikainen,
   Tiina/ABD-6622-2021; Janus, Edward/AAU-8652-2020
OI Bunker, Stephen/0000-0003-0780-4784; Laatikainen,
   Tiina/0000-0002-6614-4782; Reddy, Prasuna/0000-0002-0709-9352; Best,
   James/0000-0002-5239-9274; LO, Sing Kai/0000-0001-8401-1759
FU Australian Government Department of Health and Aging; Royal Australian
   College of General Practitioners; Sanofi-Aventis; Pfizer; Roche
   Diagnostics Australia; Servier Laboratories
FX This study was supported by the Australian Government Department of
   Health and Aging, Royal Australian College of General Practitioners,
   Sanofi-Aventis, Pfizer, Roche Diagnostics Australia, and Servier
   Laboratories.We thank Professor Kerin O'Dea, Anna Chapman, Anna
   Kao-Philpot, Dr. Andrew Baird, the nurses carrying out the survey, and
   regional hospitals providing facilities for the study.
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NR 25
TC 176
Z9 200
U1 0
U2 13
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0149-5992
EI 1935-5548
J9 DIABETES CARE
JI Diabetes Care
PD DEC
PY 2008
VL 31
IS 12
BP 2368
EP 2373
DI 10.2337/dc08-0175
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 381RB
UT WOS:000261552500028
PM 18835951
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Agirbasli, M
   Tanrikulu, AM
   Berenson, GS
AF Agirbasli, Mehmet
   Tanrikulu, Azra M.
   Berenson, Gerald S.
TI Metabolic Syndrome: Bridging the Gap from Childhood to Adulthood
SO CARDIOVASCULAR THERAPEUTICS
LA English
DT Review
DE Atherosclerosis; Cardiometabolic risk; Children; Lipids disorder;
   Metabolic syndrome
ID CARDIOVASCULAR RISK-FACTORS; HIGH-DENSITY-LIPOPROTEIN; INTIMA-MEDIA
   THICKNESS; 3RD NATIONAL-HEALTH; BODY-MASS INDEX; NUTRITION EXAMINATION
   SURVEY; SYSTOLIC BLOOD-PRESSURE; HEPATIC LIPASE ACTIVITY; SYNDROME
   SYNDROME-X; INSULIN-RESISTANCE
AB Childhood and adolescence are particularly vulnerable periods of life to the effects of cardiometabolic risk and later development of atherosclerosis, hypertension, and diabetes mellitus. Developing countries with limited resources suffer most heavily from the consequences of cardiometabolic risk in children and its future implications to the global health burden. A better understanding of mechanisms leading to cardiometabolic risk in early life may lead to more effective prevention and intervention strategies to reduce metabolic stress in children and later disease. Longitudinal tracking studies of cardiometabolic risk in children provide a tremendous global resource to direct prevention strategies for cardiovascular disease. In this review, we will summarize the pathophysiology, existing definitions for cardiometabolic risk components in children. Screening and identifying children and adolescents of high cardiometabolic risk and encouraging them and their families through healthy lifestyle changes should be implemented to as a global public health strategy.
C1 [Agirbasli, Mehmet] Medeniyet Univ, Sch Med, Dept Cardiol, TR-34726 Istanbul, Turkey.
   [Tanrikulu, Azra M.] Maltepe State Hosp, Dept Cardiol, Istanbul, Turkey.
   [Berenson, Gerald S.] Tulane Univ, Hlth Sci Ctr, Tulane Ctr Cardiovasc Hlth, Bogalusa Heart Study, New Orleans, LA 70118 USA.
C3 Istanbul Medeniyet University; Maltepe State Hospital; Tulane
   University; Tulane University Hospital
RP Agirbasli, M (corresponding author), Medeniyet Univ, Sch Med, Dept Cardiol, Yesilbahar Sok 68-14 Goztepe, TR-34726 Istanbul, Turkey.
EM magirbasli@gmail.com
RI Agirbasli, Mehmet/AFP-1794-2022
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NR 72
TC 57
Z9 64
U1 2
U2 12
PU WILEY-HINDAWI
PI LONDON
PA ADAM HOUSE, 3RD FL, 1 FITZROY SQ, LONDON, WIT 5HE, ENGLAND
SN 1755-5914
EI 1755-5922
J9 CARDIOVASC THER
JI Cardiovasc. Ther.
PD FEB
PY 2016
VL 34
IS 1
BP 30
EP 36
DI 10.1111/1755-5922.12165
PG 7
WC Cardiac & Cardiovascular Systems; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Pharmacology & Pharmacy
GA DA5GL
UT WOS:000367831100005
PM 26588351
OA Bronze
DA 2025-06-11
ER

PT J
AU Ribeiro, RP
   Marziale, MHP
   Martins, JT
   Ribeiro, PHV
   Robazzi, MLDC
   Dalmas, JC
AF Ribeiro, Renata Perfeito
   Palucci Marziale, Maria Helena
   Martins, Julia Trevisan
   Vivan Ribeiro, Patricia Helena
   do Carmo Cruz Robazzi, Maria Lucia
   Dalmas, Jose Carlos
TI Prevalence of Metabolic Syndrome among nursing personnel and its
   association with occupational stress, anxiety and depression
SO REVISTA LATINO-AMERICANA DE ENFERMAGEM
LA English
DT Article
DE Occupational Health; Obesity; Metabolism; Burnout; Professional;
   Anxiety; Depression; Nursing
ID SCALE; WORKERS; CARE
AB Objective: to identify the prevalence of Metabolic Syndrome among nursing personnel, and its association with occupational stress, anxiety and depression. Method: a descriptive correlational study undertaken with 226 nursing personnel from a teaching hospital. Data collection was undertaken through application of the Job Stress Scale, the Hospital Anxiety and Depression Scale and a sociodemographic questionnaire, with variables of Metabolic Syndrome. Univariate analyses and Chi-squared and Pearson tests were used for correlation between the variables, with a level of significance of 5%. Results: 86 (38.1%) workers presented Metabolic Syndrome, of whom 183 (81.1%) were female, and 43 (19.9%) male, aged between 23 and 66 years old. In relation to anxiety and depression, 154 (68.1%) presented anxiety, with 48 (31.2%) also presenting Metabolic Syndrome; 185 (81.8%) presented depression, of whom 62 (33.5%) also had Metabolic Syndrome. It was ascertained that 61 (27.0%) workers presented stress and that of these, 14 (22.9%) presented Metabolic Syndrome. Conclusion: a correlation was observed between the variables of anxiety and Metabolic Syndrome and stress and Metabolic Syndrome, there being no correlation between the variables of depression and Metabolic Syndrome.
C1 [Ribeiro, Renata Perfeito; Martins, Julia Trevisan; Dalmas, Jose Carlos] Univ Estadual Londrina, Dept Enfermagem, Londrina, PR, Brazil.
   [Palucci Marziale, Maria Helena; do Carmo Cruz Robazzi, Maria Lucia] Univ Sao Paulo, Escola Enfermagem Ribeirao Preto, PAHO WHO Collaborating Ctr Nursing Res Dev, BR-14049 Ribeirao Preto, SP, Brazil.
   [Vivan Ribeiro, Patricia Helena] Univ Estadual Londrina, Clin Odontol Univ, Londrina, PR, Brazil.
C3 Universidade Estadual de Londrina; Universidade de Sao Paulo;
   Universidade Estadual de Londrina
RP Ribeiro, RP (corresponding author), Rua Santos 488,Apto 64, BR-86020040 Londrina, PR, Brazil.
EM perfeitorenata@gmail.com
RI Maria Helena Palucci Marziale, M.H.P./I-6409-2012; Ribeiro,
   Patricia/HTQ-4317-2023; Cruz Robazzi, Maria Lucia do Carmo/E-1527-2019
OI Marziale, Maria Helena Palucci/0000-0003-2790-3333; Cruz Robazzi, Maria
   Lucia do Carmo/0000-0003-2364-5787
FU Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq),
   Brazil [140936/2009-2]
FX Paper extracted from doctoral dissertation "Prevalence of Metabolic
   Syndrome among workers in medical and nursing staff of hospital in
   Parana and its association with occupational stress, anxiety and
   depression", presented to Escola de Enfermagem de Ribeirao Preto,
   Universidade de Sao Paulo, PAHO/WHO Collaborating Centre for Nursing
   Research Development, Ribeirao Preto, SP, Brazil. Supported by Conselho
   Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq), Brazil,
   process # 140936/2009-2.
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NR 25
TC 27
Z9 35
U1 0
U2 38
PU UNIV SAO PAULO, ESCOLA DE ENFERMAGEM DE RIBEIRAO PRETO
PI RIBEIRAO PRETO
PA AV BANDEIRANTES, 3900, RIBEIRAO PRETO, SP 14040-902  A, BRAZIL
SN 1518-8345
J9 REV LAT-AM ENFERM
JI Rev. Latino-Am. Enfermagem
PD MAY-JUN
PY 2015
VL 23
IS 3
BP 435
EP 440
DI 10.1590/0104-1169.0383.2573
PG 6
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA CP9EL
UT WOS:000360196400011
PM 26155007
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Lam, PH
   Chen, ED
   Jiang, T
   Moon, H
   Passarelli, V
   Kim, J
   Miller, GE
AF Lam, Phoebe H.
   Chen, Edith
   Jiang, Tao
   Moon, Hee
   Passarelli, Veronica
   Kim, Jungwon
   Miller, Gregory E.
TI Responsive parental support buffers the link between chronic stress and
   cardiometabolic risk among adolescents
SO BRAIN BEHAVIOR AND IMMUNITY
LA English
DT Article
DE Parental support; Timing; Adolescence; Inflammation; Metabolic syndrome
ID METABOLIC SYNDROME; SOCIAL SUPPORT; INSULIN-RESISTANCE;
   CARDIOVASCULAR-DISEASE; PSYCHOLOGICAL STRESS; BLOOD-PRESSURE; LIFE-SPAN;
   CHILDHOOD; INFLAMMATION; HEALTH
AB Youth exposed to chronic stress exhibit increased cardiometabolic risk which parental social support may attenuate. Notably, theories emphasize that support should be delivered responsively for it to exert buffering effects, but this has not been thoroughly tested empirically. This study examined whether timing of support is an important but unrecognized element of responsiveness during adolescence in buffering the link between chronic stress and cardiometabolic risk. Participants were 242 adolescents aged 15 years (63 % female, 38 % Black). Adolescents completed assessments of chronic stress (Life Stress Interview), and trained personnel collected anthropometric measures and blood samples to assess cardiometabolic risk (reflected in low-grade inflammation and metabolic syndrome). Adolescents also completed an eight-day diary assessment to report daily stressor exposure and parental support. Using the diary data, responsiveness of parental support was operationalized as the within-individual difference in parental support received on stressor (vs. non-stressor) days, such that increased parental support on stressor days reflected more timely support. Results suggest that responsive parental support buffered the link between chronic stress and cardiovascular risk. Specifically, chronic stress was associated with greater risk only when parental support was not temporally aligned with stress exposure, but this association was not observed among adolescents who received timely parental support. These findings shed light on why parental support may not always exert buffering effects during adolescence, highlighting the importance of taking a developmental approach to understanding protective effects.
C1 [Lam, Phoebe H.] Carnegie Mellon Univ, Dept Psychol, Pittsburgh, PA USA.
   [Chen, Edith; Miller, Gregory E.] Northwestern Univ, Dept Psychol, Evanston, IL USA.
   [Chen, Edith; Jiang, Tao; Moon, Hee; Passarelli, Veronica; Kim, Jungwon; Miller, Gregory E.] Northwestern Univ, Inst Policy Res, Evanston, IL USA.
   [Lam, Phoebe H.] 4909 Frew St,Suite 354E, Pittsburgh, PA 15213 USA.
C3 Carnegie Mellon University; Northwestern University; Northwestern
   University
RP Lam, PH (corresponding author), 4909 Frew St,Suite 354E, Pittsburgh, PA 15213 USA.
EM phoebelam@cmu.edu
OI Miller, Gregory/0000-0002-7217-1082
FU National Institutes of Health [HL122328, HL136676, F31 HL147509]
FX <BOLD>Funding</BOLD> This research was supported by a grant from the
   National Institutes of Health HL122328 (GEM) , HL136676 (EC) , F31
   HL147509 (PHL) .
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NR 66
TC 2
Z9 2
U1 2
U2 5
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0889-1591
EI 1090-2139
J9 BRAIN BEHAV IMMUN
JI Brain Behav. Immun.
PD FEB
PY 2024
VL 116
BP 114
EP 123
DI 10.1016/j.bbi.2023.11.027
EA DEC 2023
PG 10
WC Immunology; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Neurosciences & Neurology; Psychiatry
GA DS7O5
UT WOS:001134128500001
PM 38052410
OA hybrid
DA 2025-06-11
ER

PT J
AU D'Alessio, L
   Korman, GP
   Sarudiansky, M
   Guelman, LR
   Scévola, L
   Pastore, A
   Obregón, A
   Roldán, EJA
AF D'Alessio, Luciana
   Korman, Guido Pablo
   Sarudiansky, Mercedes
   Guelman, Laura Ruth
   Scevola, Laura
   Pastore, Alejandra
   Obregon, Amilcar
   Roldan, Emilio J. A.
TI Reducing Allostatic Load in Depression and Anxiety Disorders: Physical
   Activity and Yoga Practice as Add-On Therapies
SO FRONTIERS IN PSYCHIATRY
LA English
DT Review
DE chronic stress; neuroplasticity; neurogenesis; hippocampus; cortisol;
   noradrenaline; antidepressants; benzodiazepines
ID CORONARY-HEART-DISEASE; HIPPOCAMPAL NEUROGENESIS; METABOLIC SYNDROME;
   ANTIDEPRESSANT TREATMENT; STRESS REDUCTION; SEX-DIFFERENCES;
   MENTAL-HEALTH; ANIMAL-MODEL; EXERCISE; BRAIN
AB The allostatic load (AL) index constitutes a useful tool to objectively assess the biological aspects of chronic stress in clinical practice. AL index has been positively correlated with cumulative chronic stress (physical and psychosocial stressors) and with a high risk to develop pathological conditions (e.g., metabolic syndrome, cardiovascular pathology, inflammatory disorders) and the so-called stress-related psychiatric disorders, including anxiety and depressive disorders. Chronic stress has negative effects on brain neuroplasticity, especially on hippocampal neurogenesis and these effects may be reversed by antidepressant treatments. Several evidences indicate that non-pharmacological interventions based on physical activity and yoga practice may add synergizing benefits to classical treatments (antidepressant and benzodiazepines) for depression and anxiety, reducing the negative effects of chronic stress. The aim of this review is to provide a general overview of current knowledge on AL and chronic stress in relation to depression and anxiety, physical activity and yoga practice.
C1 [D'Alessio, Luciana] Univ Buenos Aires, Fac Med, IBCN, CONICET, Buenos Aires, DF, Argentina.
   [D'Alessio, Luciana; Scevola, Laura] Univ Buenos Aires, Hosp Ramos Mejia, Buenos Aires, DF, Argentina.
   [Korman, Guido Pablo; Sarudiansky, Mercedes] Univ Buenos Aires, Fac Psicol, CAEA, CONICET, Buenos Aires, DF, Argentina.
   [Guelman, Laura Ruth] Univ Buenos Aires, Fac Psicol, CEFYBO, CONICET, Buenos Aires, DF, Argentina.
   [Pastore, Alejandra; Obregon, Amilcar; Roldan, Emilio J. A.] Gador SA, Direccion Med & Cient, Buenos Aires, DF, Argentina.
C3 Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET);
   University of Buenos Aires; University of Buenos Aires; University of
   Buenos Aires Hospital; Hospital Ramos Mejia; University of Buenos Aires;
   Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET);
   University of Buenos Aires; Consejo Nacional de Investigaciones
   Cientificas y Tecnicas (CONICET)
RP D'Alessio, L (corresponding author), Univ Buenos Aires, Fac Med, IBCN, CONICET, Buenos Aires, DF, Argentina.; D'Alessio, L (corresponding author), Univ Buenos Aires, Hosp Ramos Mejia, Buenos Aires, DF, Argentina.
EM lucianad@conicet.gov.ar
OI Sarudiansky, Mercedes/0000-0002-0030-2231; Guelman, Laura
   Ruth/0000-0002-5251-3006; D'Alessio, Luciana/0000-0002-2431-5547
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NR 127
TC 30
Z9 36
U1 2
U2 40
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-0640
J9 FRONT PSYCHIATRY
JI Front. Psychiatry
PD JUN 4
PY 2020
VL 11
AR 501
DI 10.3389/fpsyt.2020.00501
PG 10
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA MC3SH
UT WOS:000543210600001
PM 32581876
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Richard, SL
   Renn, BN
   Kim, J
   Tran, DMT
   Feng, D
AF Richard, Shannon L.
   Renn, Brenna N.
   Kim, Jinyoung
   Tran, Dieu-My T.
   Feng, Du
TI Mental health is related to metabolic syndrome: The Hispanic community
   health study/ study of Latinos
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE Metabolic syndrome; Hispanic subgroups; Depression; Anxiety
ID RISK-FACTORS; CARDIOVASCULAR-DISEASE; MAJOR DEPRESSION; PREVALENCE;
   ANXIETY; ASSOCIATION; HISPANICS/LATINOS; METAANALYSIS; BACKGROUNDS;
   STATEMENT
AB Objective: Metabolic syndrome (MetS) is associated with common mental health conditions. Using cross-sectional data from the observational Hispanic Community Health Study / Study of Latinos (HCHS/SOL), this study examined the relationship between MetS and depression and anxiety in addition to testing moderating effects of gender and Hispanic heritage subgroups.Methods: Participants included 13,496 Hispanic Americans aged 18-74 (59% women, mean age 46.59 +/- 13.65) from seven heritage subgroups. Depression was measured using the Center for Epidemiologic Studies Depression 10-item scale, and anxiety was assessed using the State-Trait Anxiety Inventory 10-item scale. A 3-level categorical variable was developed to assess the combined influence of depression and anxiety. The dependent variable is dichotomous, delineating the presence or absence of MetS as defined by the National Cholesterol Education Program Third Adult Treatment Panel. Logistic regression and Hayes' PROCESS macro assessed these relationships and the moderating effects of gender-heritage subgroups.Results: Results suggest depression (p < .001) and anxiety (p < .001) were associated with an increased likelihood of MetS. Puerto Ricans had the highest, and South Americans had the lowest, levels of depression and anxiety. Gender moderated the relationship between mental health and MetS, with women having a significant increase in the probability of MetS with depression (p < .001), anxiety (p < .001), or both (p < .001).Conclusion: Elevated symptoms of depression and anxiety are associated with the presence of MetS in US Hispanic subgroups. Gender-heritage differences are present among the study variables. Strategies to manage psychological well-being must be employed to optimize cardiometabolic health in US Hispanics.
C1 [Richard, Shannon L.; Renn, Brenna N.; Kim, Jinyoung; Tran, Dieu-My T.; Feng, Du] 4505 S Maryland Pky, Las Vegas, NV 89154 USA.
RP Richard, SL (corresponding author), 4505 S Maryland Pky, Las Vegas, NV 89154 USA.
EM richas9@unlv.nevada.edu
RI Renn, Brenna/AAD-9964-2020
OI Feng, Du/0000-0003-0333-2687; Baker, Josh/0000-0002-2101-5215
FU National Heart, Lung, and Blood Institute (NHLBI); National Center on
   Minority Health and Health Disparities; National Institute of Deafness
   and Other Communications Disorders [N01-HC65233, N01-HC65234,
   N01-HC65235, N01-HC65236, N01-HC65237]; National Institute of Dental and
   Craniofacial Research; National Institute of Diabetes and Digestive and
   Kidney Diseases; National Institute of Neurological Disorders and
   Stroke; Office of Dietary Supplements; National Institute of General
   Medical Sciences;  [P20 GM103440]
FX The Hispanic Community Health Study/Study of Latinos was carried out as
   a collaborative study supported by contracts from the National Heart,
   Lung, and Blood Institute (NHLBI) to the University of North Carolina
   (N01-HC65233), University of Miami (N01-HC65234), Albert Einstein
   College of Medicine (N01-HC65235), Northwestern University
   (N01-HC65236), and San Diego State University (N01-HC65237). The
   following Institutes/Centers/Offices contribute to the HCHS/SOL through
   a transfer of funds to the NHLBI: National Center on Minority Health and
   Health Disparities, the National Institute of Deafness and Other
   Communications Disorders, the National Institute of Dental and
   Craniofacial Research, the National Institute of Diabetes and Digestive
   and Kidney Diseases, the National Institute of Neurological Disorders
   and Stroke, and the Office of Dietary Supplements.Dr. Renn's effort is
   supported in part by the National Institute of General Medical Sciences
   (grant P20 GM103440).
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NR 57
TC 3
Z9 3
U1 0
U2 3
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
EI 1873-3360
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD JUN
PY 2023
VL 152
AR 106085
DI 10.1016/j.psyneuen.2023.106085
EA MAR 2023
PG 9
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA D4NP0
UT WOS:000968517600001
PM 36989563
OA Bronze, Green Accepted
DA 2025-06-11
ER

PT J
AU Dark, T
   Rust, G
   Sehres, G
   Harman, JS
AF Dark, Tyra
   Rust, George
   Sehres, Gabriella
   Harman, Jeffrey S.
TI Racial Disparities in Healthcare Utilization Among Individuals with
   Cardiometabolic Risk Factors and Comorbid Anxiety Disorder
SO JOURNAL OF RACIAL AND ETHNIC HEALTH DISPARITIES
LA English
DT Article
DE Racial disparities; Cardiometabolic syndrome; Anxiety; Healthcare
   utilization
ID EMERGENCY-DEPARTMENT VISITS; MENTAL-HEALTH; UNITED-STATES; METABOLIC
   SYNDROME; CARDIOVASCULAR-DISEASE; PREVALENCE; DEPRESSION; SERVICES;
   ILLNESS; HOSPITALIZATIONS
AB Objective This study addresses racial/ethnic differences in adverse health care utilization among individuals with comorbid anxiety disorder and cardiometabolic syndrome (CMetS) risk factors. Methods Utilizing 2011-2015 Medical Expenditure Panel Survey (MEPS) data, logistic regression models were estimated to determine the likelihood of receiving CMetS-related medical treatment in the emergency department (ED) or via inpatient services and to determine if the likelihood is associated with race/ethnicity. Adjusted models controlled for age, sex, and insurance type. Results Significant racial-ethnic differences were observed for utilization (any emergency department and/or inpatient visit). The odds of non-Hispanic Black respondents reporting emergency department and/or inpatient utilization was 2.39 (p < 0.05) times the odds of non-Hispanic White respondents. Conclusion Racial-ethnic variation in adverse healthcare utilization suggests an opportunity to improve care and outcomes for persons diagnosed with comorbid anxiety disorder and cardiometabolic syndrome. Integrated interventions could simultaneously improve mental health and facilitate CMetS disease self-management.
C1 [Dark, Tyra] Florida State Univ, Ctr Translat Behav Sci, Dept Behav Sci & Social Med, Coll Med, 2010 Levy Ave,Bldg B Suite 266, Tallahassee, FL 32310 USA.
   [Rust, George; Harman, Jeffrey S.] Florida State Univ, Dept Behav Sci & Social Med, Coll Med, 1115 W Call St, Tallahassee, FL 32306 USA.
   [Sehres, Gabriella] Florida State Univ, Coll Med, 1115 W Call St, Tallahassee, FL 32306 USA.
C3 State University System of Florida; Florida State University; State
   University System of Florida; Florida State University; State University
   System of Florida; Florida State University
RP Dark, T (corresponding author), Florida State Univ, Ctr Translat Behav Sci, Dept Behav Sci & Social Med, Coll Med, 2010 Levy Ave,Bldg B Suite 266, Tallahassee, FL 32310 USA.
EM Tyra.Dark@med.fsu.edu
OI Rust, George/0000-0002-9040-9744
FU Robert Wood Johnson Foundation [73825]
FX This study was funded by Robert Wood Johnson Foundation (grant number
   73825).
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NR 33
TC 3
Z9 3
U1 1
U2 9
PU SPRINGER INT PUBL AG
PI CHAM
PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND
SN 2197-3792
EI 2196-8837
J9 J RACIAL ETHN HEALTH
JI J. Racial Ethn. Health Disparities
PD DEC
PY 2020
VL 7
IS 6
BP 1234
EP 1240
DI 10.1007/s40615-020-00748-0
EA APR 2020
PG 7
WC Public, Environmental & Occupational Health
WE Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA OZ3AR
UT WOS:000524958000001
PM 32277365
DA 2025-06-11
ER

PT J
AU Robinette, JW
   Charles, ST
   Gruenewald, TL
AF Robinette, Jennifer W.
   Charles, Susan T.
   Gruenewald, Tara L.
TI Neighborhood cohesion, neighborhood disorder, and cardiometabolic risk
SO SOCIAL SCIENCE & MEDICINE
LA English
DT Article
DE Cardiometabolic risk; Neighborhoods; Cohesion; Disorder; Anxiety;
   Physical activity; United States
ID MENTAL-HEALTH; PHYSICAL-ACTIVITY; ALLOSTATIC LOAD; SOCIAL COHESION;
   ASSOCIATIONS; MORTALITY; COMMUNITY; DISADVANTAGE; ENVIRONMENT;
   DEPRESSION
AB Perceptions of neighborhood disorder (trash, vandalism) and cohesion (neighbors trust one another) are related to residents' health. Affective and behavioral factors have been identified, but often in studies using geographically select samples. We use a nationally representative sample (n = 9032) of United States older adults from the Health and Retirement Study to examine cardiometabolic risk in relation to perceptions of neighborhood cohesion and disorder. Lower cohesion is significantly related to greater cardiometabolic risk in 2006/ 2008 and predicts greater risk four years later (2010/2012). The longitudinal relation is partially accounted for by anxiety and physical activity.
C1 [Robinette, Jennifer W.] Univ Southern Calif, Davis Sch Gerontol, 3715 McClintock Ave, Los Angeles, CA 90089 USA.
   [Charles, Susan T.] Univ Calif Irvine, Dept Psychol & Social Behav, 4201 Social & Behav Sci Gateway, Irvine, CA 92697 USA.
   [Gruenewald, Tara L.] Chapman Univ, Dept Psychol, One Univ Dr, Orange, CA 92866 USA.
C3 University of Southern California; University of California System;
   University of California Irvine; Chapman University System; Chapman
   University
RP Robinette, JW (corresponding author), Univ Southern Calif, Davis Sch Gerontol, 3715 McClintock Ave, Los Angeles, CA 90089 USA.
EM jrobinet@usc.edu
RI Robinette, Jennifer/AAY-8044-2020; Gruenewald, Tara/KLE-3300-2024
FU NIH/NIA [T32-AG000037-37, 1K99AG055699-01, R01AG042431, U01AG009740];
   National Institute on Aging [U01AG009740] Funding Source: NIH RePORTER
FX This research was based upon work supported by an NIH/NIA training grant
   (T32-AG000037-37) and a NIH/NIA career development grant
   (1K99AG055699-01) awarded to the first author and an NIH/NIA grant
   awarded to the second author (R01AG042431). The HRS (Health and
   Retirement Study) is sponsored by the NIH/NIA (U01AG009740) and is
   conducted by the University of Michigan.
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NR 44
TC 61
Z9 70
U1 5
U2 36
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0277-9536
J9 SOC SCI MED
JI Soc. Sci. Med.
PD FEB
PY 2018
VL 198
BP 70
EP 76
DI 10.1016/j.socscimed.2017.12.025
PG 7
WC Public, Environmental & Occupational Health; Social Sciences, Biomedical
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; Biomedical Social Sciences
GA GD8PR
UT WOS:000430775100010
PM 29276988
OA Bronze, Green Accepted, Green Submitted
DA 2025-06-11
ER

PT J
AU Lambert, E
   Dawood, T
   Straznicky, N
   Sari, C
   Schlaich, M
   Esler, M
   Lambert, G
AF Lambert, Elisabeth
   Dawood, Tye
   Straznicky, Nora
   Sari, Carolina
   Schlaich, Markus
   Esler, Murray
   Lambert, Gavin
TI Association between the sympathetic firing pattern and anxiety level in
   patients with the metabolic syndrome and elevated blood pressure
SO JOURNAL OF HYPERTENSION
LA English
DT Article
DE anxiety; depression; hypertension; metabolic syndrome; obesity;
   sympathetic nervous system
ID MUSCLE VASOCONSTRICTOR NEURONS; MAJOR DEPRESSIVE DISORDER; SINGLE-UNIT
   ANALYSIS; MENTAL STRESS; NOREPINEPHRINE RELEASE; RISK-FACTORS;
   SYMPATHOEXCITATION; DISCHARGE; OBESITY; WEIGHT
AB Objective Recent evidence indicates that stress is associated with obesity, hypertension and metabolic abnormalities. Stress pathways, including both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system, are activated in individuals with the metabolic syndrome. In order to gain some insight into the relation between sympathetic nervous system activation, metabolic profile and stress, we examined the pattern of sympathetic nervous firing in eight women and 17 men with the metabolic syndrome and elevated blood pressure (BP) in relation to their underlying psychological stress.
   Methods and results Both multiunit and single-unit muscle sympathetic nerve activity (MSNA) were recorded by using the technique of microneurography and psychological stress was assessed by Spielberger's State and Trait Anxiety scores and the Beck Depression Inventory II (BDI-II). Women had higher cholesterol levels, higher depressive symptom scores and similar multiunit MSNA compared with the men but displayed a disturbed firing pattern of sympathetic activity as indicated by a higher incidence of multiple spikes per burst (P < 0.05). In all individuals, regression analysis after adjustment for sex indicated that the single-unit sympathetic nerve-firing pattern did not correlate with any aspect of the metabolic profile; however it was significantly associated with anxiety state and trait and the affective component of the BDI scores. In particular, higher incidence of multiple firing (more than two spikes) during a sympathetic neural burst was associated with higher trait anxiety score (R = 0.557, P = 0.004) and higher affective depressive symptoms (R = 0.517, P = 0.008). Somatic symptoms bore no association with the sympathetic firing pattern.
   Conclusion These results suggest that chronic mental stress modulates the pattern of sympathetic activity, which, in turn, may confer greater cardiovascular risk on individuals with the metabolic syndrome and elevated BP. J Hypertens 28:543-550 (c) 2010 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
C1 [Lambert, Elisabeth; Dawood, Tye; Straznicky, Nora; Sari, Carolina; Schlaich, Markus; Esler, Murray; Lambert, Gavin] Baker IDI Heart & Diabet Inst, Human Neurotransmitters Lab, Melbourne, Vic 8008, Australia.
C3 Baker Heart and Diabetes Institute
RP Lambert, E (corresponding author), Baker IDI Heart & Diabet Inst, Human Neurotransmitters Lab, POB 6492,St Kilda Rd Cent, Melbourne, Vic 8008, Australia.
EM elisabeth.lambert@bakeridi.edu.au
RI Lambert, Elisabeth/E-7463-2010; Schlaich, Markus/E-7468-2010; Lambert,
   Gavin/E-7384-2010; Dawood, Tye/A-8826-2011; Straznicky, Nora/E-7484-2010
OI Lambert, Gavin/0000-0003-0315-645X; Schlaich,
   Markus/0000-0002-1765-0195; Lambert, Elisabeth/0000-0002-2232-9048
FU Diabetes Australia Research Trust Grant; Future Forum Research Grant;
   Heart Foundation; Australian Government [472604]; NHMRC Career
   Development Awards; NHMRC Senior Research Fellowship; NHMRC Senior
   Principal Research Fellowship; National Heart Foundation of Australia
FX This study was supported by a Diabetes Australia Research Trust Grant,
   and a Future Forum Research Grant to N.E.S. The research group also hold
   a Heart Foundation Grant-in-Aid and an NH&MRC Project Grant (472604)
   from the Australian Government. E. A. L and M. S. are supported by NHMRC
   Career Development Awards. G. W. L is supported by an NHMRC Senior
   Research Fellowship and M. D. E. by an NHMRC Senior Principal Research
   Fellowship. T.D. is supported by a National Heart Foundation of
   Australia postdoctoral fellowship. We acknowledge the contribution of Ms
   Ania Schlaich in analyzing the data.
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NR 48
TC 87
Z9 94
U1 0
U2 7
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0263-6352
EI 1473-5598
J9 J HYPERTENS
JI J. Hypertens.
PD MAR
PY 2010
VL 28
IS 3
BP 543
EP 550
DI 10.1097/HJH.0b013e3283350ea4
PG 8
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 562QN
UT WOS:000275068200018
PM 20139772
DA 2025-06-11
ER

PT J
AU Sun, J
   Zhang, N
   Buys, N
   Zhou, ZY
   Shen, SY
   Yuan, BJ
AF Sun, Jing
   Zhang, Ning
   Buys, Nicholas
   Zhou, Zheng-Yuan
   Shen, Shu-Ying
   Yuan, Bao-Jun
TI The role of Tai Chi, cultural dancing, playing a musical instrument and
   singing in the prevention of chronic disease in Chinese older adults: a
   mind-body meditative approach
SO INTERNATIONAL JOURNAL OF MENTAL HEALTH PROMOTION
LA English
DT Article
DE mind-body meditation approach; Tai Chi; cultural dancing; music;
   singing; metabolic syndrome; China
ID EXERCISE; BURDEN; PREVALENCE; PARAMETERS; MOVEMENT; THERAPY; STROKE
AB Older adults with chronic diseases have a high level of depression and poor mental health status. Previous public health interventions have attempted to reduce chronic disease-related health risks including depression and to improve mental health, but have had limited success. This study examined whether 15 months of regular participation in Tai Chi (TC) exercise, dancing, instrument playing and singing, as part of a mind-body meditative approach (MBMA), improves brain executive function, psychological functioning and mental health in Chinese older adults. Results indicated that the MBMA programme improved participants' executive function, psychological functioning, mental health and resilience, compared with a control group. These findings indicate that MBMA activities may be adopted as lifestyle approaches to promote mental health in different areas as follows: (1) TC and dancing have the biggest effect for reducing the prevalence of depression and for improving their mental health and resilience in older people with chronic conditions and (2) playing a musical instrument and singing have moderate effect for reducing depression symptoms and promoting mental health. The findings of the study suggest that there are mental health promotion implications relating to exercise type and minimal exercise dosage for older adults. Cultural dancing and TC may be a form of physical activity that is more likely to appeal to older people, when they are most at risk of being overweight or obese, of suffering from depression and/or of experiencing a decline in brain function. TC has been found to be highly effective in preventing depression and promoting brain executive function, and appears to be a form of physical activity that appeals to older people. Dancing, in combination with TC and singing, may be highly effective in protecting older adults from metabolic syndrome and brain function decline and in promoting a positive quality of life including psychological health. Playing a musical instrument may be used as an alternative method for maintaining good mental health in healthy people and for promoting mental health in people suffering from stress and its related depression and anxiety.
C1 [Sun, Jing; Buys, Nicholas] Griffith Univ, Griffith Hlth Inst, Gold Coast, Qld 4222, Australia.
   [Zhang, Ning; Zhou, Zheng-Yuan] Chang Shu Ctr Dis Control & Prevent, Dept Chron Dis Prevent, Chang Shu 215500, Jiangsu, Peoples R China.
   [Shen, Shu-Ying] Chang Shu Hlth Inspect Inst, Dept Nutr & Dietet, Chang Shu 2155006, Jiangsu, Peoples R China.
   [Yuan, Bao-Jun] Jiangsu Prov Ctr Dis Control & Prevent, Dept Nutr & Dietet, Nanjing 210009, Jiangsu, Peoples R China.
C3 Griffith University; Griffith University - Gold Coast Campus; Menzies
   Health Institute Queensland; Jiangsu Provincial Center for Disease
   Control & Prevention
RP Sun, J (corresponding author), Griffith Univ, Griffith Hlth Inst, Gold Coast Campus, Gold Coast, Qld 4222, Australia.
EM j.sun@griffith.edu.au; cscdcmbk@163.com; n.buys@griffith.edu.au;
   csmbk@163.com; 69258381@qq.com; jscdcybj@yahoo.com.cn
RI Sun, Jing/AAS-1582-2020; Buys, Nicholas/AAT-3925-2020; ZHOU, Zhou
   Zhengyuan/LIF-9650-2024
FU ChangShu Center
FX The authors wish to acknowledge the support of the ChangShu Center for
   Disease Control and Prevention and ChangShu Hospital for the data
   collection work and to all participants who participated in the study.
   The authors also wish to thank Xiao-Yan Xu and Jing Xu's assistance in
   data entry work.
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NR 27
TC 10
Z9 10
U1 3
U2 39
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 1462-3730
EI 2049-8543
J9 INT J MENT HEALTH PR
JI Int. J. Ment. Health Promot.
PY 2013
VL 15
IS 4
BP 227
EP 239
DI 10.1080/14623730.2013.842337
PG 13
WC Public, Environmental & Occupational Health; Psychiatry
WE Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; Psychiatry
GA V39SH
UT WOS:000209430200004
DA 2025-06-11
ER

PT J
AU Crichton, GE
   Murphy, KJ
   Bryan, J
AF Crichton, Georgina E.
   Murphy, Karen J.
   Bryan, Janet
TI Dairy intake and cognitive health in middle-aged South Australians
SO ASIA PACIFIC JOURNAL OF CLINICAL NUTRITION
LA English
DT Article
DE dairy products; milk; cognition; mental health; metabolic syndrome
ID DIETARY FATTY-ACIDS; METABOLIC SYNDROME; BLOOD-PRESSURE; RISK-FACTORS;
   ALZHEIMER-DISEASE; YOUNG-ADULTS; CONSUMPTION; OBESITY; IMPAIRMENT; FOOD
AB Background: Consumption of low fat dairy foods may decrease the risk of obesity, type 2 diabetes, hypertension, and all cardiovascular risk factors linked with increased probability of cognitive impairment. Aim: To examine associations between dairy intake and self-reported cognitive function and psychological well-being, and to test the novel hypothesis that dairy consumption may benefit cognitive health via its positive effects on cardiometabolic health. Methods: Retrospective cross-sectional analyses were undertaken on data from food frequency questionnaires and self-reported health of 432 men and 751 women, aged 39 to 65 years. Health measures included cardiometabolic health indicators, cognitive and memory functioning, mental health, anxiety, stress, depression and self-esteem; assessed by standardised questionnaires. Results: Regression analyses, adjusted for total energy intake and other health confounders, showed that consumption of low fat yogurt was associated with increased quality of memory recall (p=0.029) and greater social functioning (p=0.045) in men. Consumption of low fat cheese was associated with greater social functioning (p=0.021) and decreased stress (p=0.042) in women. Intakes of whole fat dairy products, including ice-cream and cream, were associated with increased depression, anxiety, stress, cognitive failures, poorer memory functioning and general health (all p<0.05). There was no association between cardiometabolic health indicators and dairy consumption. Conclusions: Low fat dairy may have beneficial effects on social functioning, stress and memory, while whole fat dairy may be associated with poorer psychological well-being. Dietary intervention trials are needed to establish whether there is a direct effect of dairy consumption on cognitive and psychological health.
C1 [Crichton, Georgina E.; Murphy, Karen J.; Bryan, Janet] Univ S Australia, Nutr Physiol Res Ctr, Adelaide, SA 5001, Australia.
   [Crichton, Georgina E.; Bryan, Janet] Univ S Australia, Sch Psychol, Adelaide, SA 5001, Australia.
C3 University of South Australia; University of South Australia
RP Crichton, GE (corresponding author), Univ S Australia, Nutr Physiol Res Ctr, GPO Box 2471, Adelaide, SA 5001, Australia.
EM Georgina.Crichton@postgrads.unisa.edu.au
RI Murphy, Karen/B-5163-2009; Bryan, Janet/F-3731-2013
OI Murphy, Karen/0000-0002-2589-1319
FU CSIRO
FX This study was funded by CSIRO appropriation funds. The authors,
   Georgina Crichton, Karen Murphy and Janet Bryan, declare no conflicts of
   interest.
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NR 61
TC 55
Z9 61
U1 0
U2 24
PU H E C PRESS, HEALTHY EATING CLUB PTY LTD
PI MCKINNON
PA PO BOX 4121, MCKINNON, VIC 3204, AUSTRALIA
SN 0964-7058
EI 1440-6047
J9 ASIA PAC J CLIN NUTR
JI Asia Pac. J. Clin. Nutr.
PY 2010
VL 19
IS 2
BP 161
EP 171
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 605MH
UT WOS:000278351200002
PM 20460228
DA 2025-06-11
ER

PT J
AU Prajitno, JN
   Susanto, H
   Soelistijo, SA
AF Prajitno, J. N.
   Susanto, H.
   Soelistijo, S. A.
TI PHYSICAL INACTIVITY AND ANXIETY WITH CARDIOMETABOLIC RISK FACT OR IN
   TYPE 2 DIABETES MELLITUS PATIENTS DURING CORONAVIRUS DISEASE 2019
   PANDEMIC
SO NEW ARMENIAN MEDICAL JOURNAL
LA English
DT Article
DE COVID-19 pandemic; physical activity; anxiety; cardiometabolic risk;
   triglycerides; HbA1c; type 2 diabetes mellitus
ID METABOLIC SYNDROME; SITTING TIME; DEPRESSION; ASSOCIATIONS; SYMPTOMS;
   HEALTH; POPULATION; PREVALENCE; DISORDERS; MORTALITY
AB COVID-19 is a pandemic that makes most people stay at home. Sedentary behavior caused by physical inactivity and anxious disorder significantly impact health condition, especially in type 2 diabetes mellitus population. This study aimed to obtain a correlation between physical inactivity and anxiety in health problems in type 2 diabetes mellitus patients, especially their effect on cardiometabolic risk.
   We obtained 76 samples from the outpatient endocrinology clinic's medical record. Physical activity and anxiety were measured using a questionnaire. Anthropometry, blood pressure, and many laboratories marker for cardiometabolic risk would be our object to analyze.
   There were increases in the cardiometabolic risk markers, including triglyceride, low-density lipoprotein cholesterol, total cholesterol, blood pressure during pandemic associated with decreased physical activity and anxiety. Moreover, increased triglyceride was correlated significantly with decreased physical activity (p=0.006), and HbA1c was correlated significantly with the increase of anxiousness (p<0.05), respectively.
   COVID-19 pandemic impacts worsening cardiometabolic risk in type 2 diabetes mellitus patients due to limitations on physical activity and anxiety levels, significantly related to increases in triglyceride and HbA1C values.
C1 [Prajitno, J. N.; Susanto, H.; Soelistijo, S. A.] Univ Airlangga, Dr Soetomo Teaching Hosp, Fac Med, Dept Internal Med, Surabaya, Indonesia.
C3 Airlangga University
RP Soelistijo, SA (corresponding author), Univ Airlangga, Dr Soetomo Teaching Hosp, Dept Internal Med, Prof Dr Moestopo St 4-6, Surabaya 60286, Indonesia.
EM soebagijo@yahoo.com
RI soelistijo, soebagijo/AAE-1673-2021
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NR 44
TC 0
Z9 0
U1 0
U2 4
PU YEREVAN STATE MEDICAL UNIV
PI YEREVAN
PA 2 KORYUN ST, YEREVAN, 0025, ARMENIA
SN 1829-0825
J9 NEW ARMEN MED J
JI New Armen. Med. J.
PY 2020
VL 14
IS 4
BP 82
EP 87
PG 6
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA PS4ZY
UT WOS:000607932400009
DA 2025-06-11
ER

PT J
AU Firdaus, M
   Mathew, MK
   Wright, J
AF Firdaus, M
   Mathew, MK
   Wright, J
TI The role of lifestyle in the metabolic syndrome
SO GERIATRICS-US
LA English
DT Article
DE metabolic syndrome; obesity; diabetes mellitus; behavior and lifestyle
   modifications
ID TYPE-2 DIABETES-MELLITUS; INSULIN-RESISTANCE; CARDIOVASCULAR-DISEASE;
   RISK-FACTOR; PREVENTION; HEART; EPIDEMIC; GLUCOSE; OBESITY; STRESS
AB The metabolic syndrome, also known as dysmetabolic syndrome, Syndrome X, or insulin resistance syndrome, is an amalgam of obesity-related health risks that significantly increases the chance of developing diabetes, coronary artery disease, and stroke. Progress in understanding the metabolic syndrome has confirmed the importance of metabolic imbalances in the development of serious and chronic cardiovascular, neurologic, immunologic, renal, and endocrine diseases. Crucial to planning treatment is the understanding that the metabolic syndrome is largely a disorder caused by behavior, thus its most important therapeutic intervention entails lifestyle change: Significant behavioral change can dramatically modify and even reverse all factors of the metabolic syndrome and its consequences. We examine the pathophysiology of the metabolic syndrome and provide strategies to encourage weight loss and dietary modifications and to promote increased physical activity.
C1 Univ Oklahoma, Coll Med, Dept Internal Med, Endocrinol Sect, Oklahoma City, OK 73190 USA.
   Univ Oklahoma, Coll Med, Donald W Reynolds Dept Geriatr, Oklahoma City, OK 73190 USA.
C3 University of Oklahoma System; University of Oklahoma Health Sciences
   Center; University of Oklahoma System; University of Oklahoma Health
   Sciences Center
RP Univ Oklahoma, Coll Med, Dept Internal Med, Endocrinol Sect, Oklahoma City, OK 73190 USA.
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NR 31
TC 8
Z9 11
U1 0
U2 1
PU ADVANSTAR COMMUNICATIONS INC
PI DULUTH
PA 131 W 1ST STREET, DULUTH, MN 55802 USA
SN 0016-867X
EI 1936-5764
J9 GERIATRICS-US
JI Geriatrics
PD FEB
PY 2006
VL 61
IS 2
BP 18
EP +
PG 9
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA 014LZ
UT WOS:000235483000011
PM 16466280
DA 2025-06-11
ER

PT J
AU Vancampfort, D
   Knapen, J
   Probst, M
   van Winkel, R
   Deckx, S
   Maurissen, K
   Peuskens, J
   De Hert, M
AF Vancampfort, Davy
   Knapen, Jan
   Probst, Michel
   van Winkel, Ruud
   Deckx, Seppe
   Maurissen, Katrien
   Peuskens, Joseph
   De Hert, Marc
TI Considering a frame of reference for physical activity research related
   to the cardiometabolic risk profile in schizophrenia
SO PSYCHIATRY RESEARCH
LA English
DT Review
DE Physical activity; Exercise; Health related lifestyle; Physical fitness;
   Mental health
ID INDUCED WEIGHT-GAIN; LIFE-STYLE INTERVENTION; QUALITY-OF-LIFE; METABOLIC
   SYNDROME; DIABETES-MELLITUS; DOUBLE-BLIND; BODY-WEIGHT;
   GLUCOSE-TOLERANCE; SELF-ESTEEM; SCHIZOAFFECTIVE DISORDER
AB This article reviews evidence that researchers and mental health service providers need to take into account four modifiable factors that affect the prevalence of the metabolic syndrome in people with schizophrenia: (a) physical activity as part of a health-related lifestyle, (b) physical fitness, (c) mental health status and (d) antipsychotic medication. The implementation of physical activity in order to prevent and treat cardiometabolic risk factors in people with schizophrenia is discussed. English language articles published until July 2009 were identified by PubMed, CINAHL, PsychINFO, and Cochrane Central Register of Controlled Trials. The search terms schizophrenia and metabolic syndrome, physical activity, health, fitness, and lifestyle were used. Physical activity interventions result in positive effects on metabolic outcomes, physical fitness, health-related behavior and mental health. Considering present knowledge, physical therapists should take into account the emotional (negative symptoms, self-esteem, self-efficacy, and stress) and physiological (cardiometabolic parameters) components of mental illness when offering physical activity interventions. The physical activity stimulus should be adapted to the individual's physical fitness level and the side effects of the antipsychotic medications. More research is needed to assist in the practical development of effective evidence-based preventive and curative strategies in psychiatric services for metabolic syndrome in persons with schizophrenia. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
C1 [Vancampfort, Davy; Knapen, Jan; Probst, Michel; van Winkel, Ruud; Deckx, Seppe; Maurissen, Katrien; Peuskens, Joseph; De Hert, Marc] Katholieke Univ Leuven, Univ Psychiat Ctr, B-3070 Kortenberg, Belgium.
   [Vancampfort, Davy; Knapen, Jan; Probst, Michel; Deckx, Seppe; Maurissen, Katrien] Katholieke Univ Leuven, Fac Kinesiol & Rehabil Sci, B-3070 Kortenberg, Belgium.
C3 KU Leuven; KU Leuven
RP Vancampfort, D (corresponding author), Katholieke Univ Leuven, Univ Psychiat Ctr, Campus Kortenberg,Leuvensesteenweg 517, B-3070 Kortenberg, Belgium.
EM Davy.Vancampfort@uc-kortenberg.be
RI Vancampfort, Davy/AAD-1987-2019; Probst, Michel/ABE-6137-2020; De Hert,
   Marc/AAH-6090-2021; van Winkel, Ruud/B-9486-2008
OI van Winkel, Ruud/0000-0001-6262-1935; De Hert, Marc/0000-0003-4255-5920
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NR 127
TC 103
Z9 117
U1 0
U2 19
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0165-1781
J9 PSYCHIAT RES
JI Psychiatry Res.
PD MAY 30
PY 2010
VL 177
IS 3
BP 271
EP 279
DI 10.1016/j.psychres.2010.03.011
PG 9
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 609MB
UT WOS:000278659600001
PM 20406713
DA 2025-06-11
ER

PT J
AU Villasis-Keever, MA
   Zurita-Cruz, JN
   Pichardo-Estrada, AZ
   Mazón-Aguirre, WA
AF Villasis-Keever, Miguel Angel
   Zurita-Cruz, Jessie Nallely
   Pichardo-Estrada, Areli Zulema
   Mazon-Aguirre, Wendy Alejandra
TI The relationship between anxiety and cardiometabolic risk factors in
   adolescents with obesity: propensity scores
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Article
DE obesity; anxiety; metabolic syndrome; insulin resistance;
   cardiometabolic factors
ID INSULIN-RESISTANCE; METABOLIC SYNDROME; SCIENTIFIC STATEMENT; DEPRESSIVE
   SYMPTOMS; EMOTIONAL DISORDERS; CARDIOVASCULAR RISK; URIC-ACID; CHILDREN;
   PREVALENCE; ASSOCIATION
AB Background: It has been described that there is a relationship between metabolic health and anxiety. Objective: To determine the relationship between anxiety and metabolic syndrome, as well as cardiometabolic risk factors, in adolescents with obesity. Methods: We conducted a comparative cross-sectional study of adolescents with obesity between January 2019 and December 2022. In each patient, we recorded somatometric measurements, lipid profiles, and serum insulin levels. Anxiety was measured using the Spence Children's Anxiety Scale. Participants were divided into those with and without anxiety. Patients with anxiety were matched to patients without anxiety using propensity scores based on z-score body mass index (zBMI). Mann-Whitney U tests and chi 2 tests were used. Results: Of the 564 adolescents, 32.6% (n = 184) suffered from anxiety. In the overall study population, no differences in biochemical and cardiometabolic parameters were observed between the adolescents with and without anxiety prior to adjusting the groups based on zBMI. After matching using their zBMI, we found that the adolescents with anxiety had higher serum uric acid levels (5.9 mg/dl vs. 5.4 mg/dl, p = 0.041), an increased incidence of metabolic syndrome (39.1% vs. 15.9%, p = 0.002), hyperglycemia (21.7% vs. 8.6%, p = 0.020), and lower HDLc (67.3% vs. 34.7%, p < 0.001), than those without anxiety. Girls with anxiety had a higher proportion of cardiometabolic risk factors compared to those without anxiety. Conclusions: Adolescents with obesity and anxiety had higher cardiometabolic risk factors than those without anxiety.
C1 [Villasis-Keever, Miguel Angel; Pichardo-Estrada, Areli Zulema; Mazon-Aguirre, Wendy Alejandra] Hosp Pediat Mexico City, Natl Med Ctr Century 21, Res Unit Anal & Synth Evidence, Inst Mexicano Seguro Social, Mexico City, Mexico.
   [Zurita-Cruz, Jessie Nallely] Univ Nacl Autonoma Mexico, Hosp Infantil Mexico Federico Gomez, Fac Med, Mexico City, Mexico.
C3 Instituto Mexicano del Seguro Social; Universidad Nacional Autonoma de
   Mexico; Hospital Infantil de Mexico Federico Gomez
RP Zurita-Cruz, JN (corresponding author), Univ Nacl Autonoma Mexico, Hosp Infantil Mexico Federico Gomez, Fac Med, Mexico City, Mexico.
EM zuritajn@hotmail.com
RI Villasís-Keever, Miguel/ABB-7807-2020
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NR 47
TC 1
Z9 1
U1 2
U2 2
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD FEB 6
PY 2025
VL 16
AR 1477006
DI 10.3389/fendo.2025.1477006
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA X5T3L
UT WOS:001425966400001
PM 39980848
OA gold
DA 2025-06-11
ER

PT J
AU Maslov, B
   Marcinko, D
   Milicevic, R
   Babic, D
   Dordevic, V
   Jakovljevic, M
AF Maslov, Boris
   Marcinko, Darko
   Milicevic, Ruza
   Babic, Dragan
   Dordevic, Veljko
   Jakovljevic, Miro
TI Metabolic Syndrome, Anxiety, Depression and Suicidal Tendencies in
   Post-Traumatic Stress Disorder and Schizophrenic Patients
SO COLLEGIUM ANTROPOLOGICUM
LA English
DT Article
DE metabolic syndrome; schizophrenia; post-traumatic stress disorder;
   anxiety; depression; suicidal tendency; lipids; hypertension
ID UNIVERSITY HOSPITAL CENTER; CRISIS-INTERVENTION; SERUM-CHOLESTEROL;
   VETERANS
AB Persons with schizophrenia and post-traumatic stress disorder (PTSD) tend to have higher psychiatric and somatic morbidity. They typically have higher rates of substances abuse (including smoking), more prevalent obesity, diabetes mellitus, and cardiovascular disease (CVD). This is especially well seen in case of the metabolic syndrome, with a, number of published studies on psychiatric patients in the last few years. This study investigated the associations between metabolic syndrome, anxiety, depression and suicidal tendency in schizophrenic and combat-related PTSD patients controlled by healthy controls. Higher rates of anxiety, depression and recent life changes scores in participants with metabolic syndrome were recorded compared to those without metabolic syndrome. Suicidal tendencies were equally present in both groups.
C1 [Maslov, Boris] Univ Mostar, Dept Psychiat, Sch Med, Mostar 88000, Bosnia & Herceg.
   [Marcinko, Darko; Dordevic, Veljko; Jakovljevic, Miro] Univ Zagreb, Univ Hosp Ctr Zagreb, Dept Psychiat, Zagreb, Croatia.
C3 University of Mostar; University of Zagreb; UNIVERSITY ZAGREB HOSPITAL
RP Maslov, B (corresponding author), Univ Mostar, Dept Psychiat, Sch Med, Mostar 88000, Bosnia & Herceg.
EM boris.maslov@tel.net.ba
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   Jakovljevic Miro, 2006, Psychiatr Danub, V18, P169
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   Maslov B, 2008, PSYCHIAT DANUB, V20, P384
NR 16
TC 19
Z9 20
U1 0
U2 8
PU COLLEGIUM ANTROPOLOGICUM
PI ZAGREB
PA INST ANTHROPOLOGICAL RESEARCH, GAJEVA 32, PO BOX 290, HR-10000 ZAGREB,
   CROATIA
SN 0350-6134
J9 COLLEGIUM ANTROPOL
JI Coll. Anthropol.
PD DEC
PY 2009
VL 33
SU 2
BP 7
EP 10
PG 4
WC Anthropology
WE Social Science Citation Index (SSCI)
SC Anthropology
GA 543CF
UT WOS:000273546800002
PM 20120396
DA 2025-06-11
ER

PT J
AU Ginsburg, DK
   Salinas, DB
   Cosanella, TM
   Wee, CP
   Saeed, MM
   Keens, TG
   Gold, JI
AF Ginsburg, Daniella K.
   Salinas, Danieli B.
   Cosanella, Taylor M.
   Wee, Choo Phei
   Saeed, Muhammed M.
   Keens, Thomas G.
   Gold, Jeffrey I.
TI High rates of anxiety detected in mothers of children with inconclusive
   cystic fibrosis screening results
SO JOURNAL OF CYSTIC FIBROSIS
LA English
DT Article
DE CRMS; CFSPID; Cystic fibrosis; Newborn screening; Mental health;
   Anxiety; Depression
ID DEPRESSIVE SYMPTOMS; INTOLERANCE; UNCERTAINTY; DISORDERS; ADHERENCE;
   PARENTS
AB Objective: The purpose was to assess postpartum depression, anxiety, and depression in mothers of chil-dren with an inconclusive diagnosis after a positive cystic fibrosis (CF) newborn screening (NBS), known as cystic fibrosis transmembrane conductance regulator (CFTR)-related metabolic syndrome (CRMS) or CF screen positive, inconclusive diagnosis (CFSPID). There is limited information on the prognosis and on the impact of this designation on maternal mental health.Methods: Mothers of children with CRMS/CFSPID and CF identified by NBS were recruited from two centers in California. Maternal mental health was assessed using measures of depression, anxiety, and a scripted interview. Descriptive statistics and multivariate logistic regression were applied for data report -ing.Results: A total of 109 mothers were recruited: CF: 51, CRMS/CFSPID: 58. Mothers from both groups showed higher rates of depression and anxiety symptoms than women in the general population. CRMS/CFSPID and CF mothers had no significant difference on their self-reported symptoms of anxiety and depression after adjusting for potential confounders. Mothers equally reported that their child's diag-nosis had a negative impact, and that genetic counseling had a positive impact on their emotional health.Conclusions: CF and CRMS/CFSPID diagnoses impact maternal mental health similarly. Uncertain progno-sis of CRMS/CFSPID likely contributed to the negative mental health impact. Providers should consider conducting mental health screening for every mother of a child with CRMS/CFSPID, in addition to the recommended mental health screening for mothers of children with CF. Genetic counseling has potential to mitigate emotional stress on these families.& COPY; 2022 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved.
C1 [Ginsburg, Daniella K.; Salinas, Danieli B.; Cosanella, Taylor M.; Keens, Thomas G.] Univ Southern Calif, Childrens Hosp Los Angeles, Keck Sch Med, Div Pulmonol,Dept Pediat, Los Angeles, CA 90007 USA.
   [Wee, Choo Phei] USC, Keck Sch Med, Dept Populat & Publ Hlth Sci, Southern Calif Clin & Translat Sci Inst SC CTSI, Los Angeles, CA USA.
   [Saeed, Muhammed M.] Kaiser Permanente Los Angeles Med Ctr, Div Pediat Pulmonol, Los Angeles, CA USA.
   [Gold, Jeffrey I.] Univ Southern Calif, Keck Sch Med, Dept Anesthesiol Pediat Psychiat & Behav Sci, Los Angeles, CA USA.
   [Gold, Jeffrey I.] Childrens Hosp Los Angeles, Saban Res Inst, Dept Anesthesiol Crit Care Med, 4650 Sunset Blvd MS 12, Los Angeles, CA 90027 USA.
C3 University of Southern California; Children's Hospital Los Angeles;
   University of Southern California; University of Southern California
   Keck Hospital; Kaiser Permanente; University of Southern California;
   Children's Hospital Los Angeles
RP Gold, JI (corresponding author), Univ Southern Calif, Childrens Hosp Los Angeles, Keck Sch Med, Div Pulmonol,Dept Pediat, Los Angeles, CA 90007 USA.
EM jgold@chla.usc.edu
FU U.S. Cystic Fibrosis Foundation (CFF) [GINSBU19B0, GINSBU20D0,
   SALINA18Y5, SALINA19A0-I, UL1TR001855, UL1TR000130]; National Center for
   Advancing Translational Science (NCATS) of the U.S. National Institutes
   of Health
FX Funding/support Daniella Ginsburg and Danieli Salinas receive funding
   from the U.S. Cystic Fibrosis Foundation (CFF) ; grant #GINSBU19B0,
   #GINSBU20D0, #SALINA18Y5, #SALINA19A0-I. The contents of this manuscript
   are solely the responsibility of the authors and do not necessarily
   represent the official views of the CFF. Choo Phei Wee is supported by
   grants UL1TR001855 and UL1TR000130 from the National Center for
   Advancing Translational Science (NCATS) of the U.S. National Institutes
   of Health. The content is solely the respon-sibility of the authors and
   does not necessarily represent the offi-cial views of the National
   Institutes of Health.
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NR 33
TC 17
Z9 17
U1 0
U2 4
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1569-1993
EI 1873-5010
J9 J CYST FIBROS
JI J. Cyst. Fibros
PD MAY
PY 2023
VL 22
IS 3
BP 420
EP 426
DI 10.1016/j.jcf.2022.12.002
EA JUN 2023
PG 7
WC Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Respiratory System
GA K7XP7
UT WOS:001018535400001
PM 36528525
OA Bronze, Green Accepted
DA 2025-06-11
ER

PT J
AU Dehghan, P
   Nejati, M
   Vahid, F
   Almasi-Hashiani, A
   Saleh-Ghadimi, S
   Parsi, R
   Jafari-Vayghan, H
   Shivappa, N
   Hébert, JR
AF Dehghan, Parvin
   Nejati, Marzieh
   Vahid, Farhad
   Almasi-Hashiani, Amir
   Saleh-Ghadimi, Sevda
   Parsi, Reza
   Jafari-Vayghan, Hamed
   Shivappa, Nitin
   Hebert, James R.
TI The association between dietary inflammatory index, dietary antioxidant
   index, and mental health in adolescent girls: an analytical study
SO BMC PUBLIC HEALTH
LA English
DT Article
DE Dietary inflammatory index; Dietary antioxidant index; Mental health;
   Adolescent girls
ID MIDDLE-AGED WOMEN; DEPRESSIVE SYMPTOMS; METABOLIC SYNDROME; OXIDATIVE
   STRESS; CARDIOVASCULAR-DISEASE; COLORECTAL-CANCER; PROSTATE-CANCER;
   DNA-DAMAGE; RISK; CAPACITY
AB Background Diet is considered as one of the modifiable factors that appears to exert a vital role in psychological status. In this way, we designed this study to examine the association between dietary inflammatory index (DII), dietary antioxidant index (DAI), and mental health in female adolescents. Methods This cross-sectional study included 364 female adolescents selected from high schools in the five regions of Tabriz, Iran. A 3-day food record was used to extract the dietary data and calculate DII/DAI scores. DII and DAI were estimated to assess the odds of depression, anxiety, and stress based on the Depression Anxiety Stress Scales-21. Adjusted relationships of the DII and DAI with depression, anxiety, and stress were determined using multiple regression after adjusting for age, energy intake, BMI, family income and mother and father education. Overweight was defined as body mass index (BMI)-for-age > + 1 z-score relative to world health organization standards. Results Depression, anxiety, and stress were observed in 21.4%, 26.6%, and 25.7% of subjects, respectively. The percentage of overweight among adolescents was 19.4%. The association between DII and score of mental health profile was positive among subjects in the third tertile of DII compared to subjects in the first tertile. However, this association was not statistically significant after adjusting for confounding variables. Moreover, there was a significant inverse association between DAI and depression and anxiety; and a statistically insignificant association between DAI and stress after adjusting for confounders. Conclusions Our results highlighted the importance of a healthy and anti-inflammatory diet on mental health in female adolescents. Therefore, modifying unhealthy dietary habits are likely to be effective in the management of psychosocial disorders.
C1 [Dehghan, Parvin; Parsi, Reza] Tabriz Univ Med Sci, Fac Nutr & Food Sci, Nutr Res Ctr, Tabriz, Iran.
   [Dehghan, Parvin] Tabriz Univ Med Sci, Fac Nutr & Food Sci, Dept Biochem & Diet Therapy, Tabriz, Iran.
   [Nejati, Marzieh] Tabriz Univ Med Sci, Student Res Comm, Tabriz, Iran.
   [Vahid, Farhad] Luxembourg Inst Hlth, Populat Hlth Dept, Nutr & Hlth Grp, Strassen, Luxembourg.
   [Almasi-Hashiani, Amir] Arak Univ Med Sci, Sch Hlth, Dept Epidemiol, Arak, Iran.
   [Saleh-Ghadimi, Sevda] Tabriz Univ Med Sci, Clin Res Dev Unit, Tabriz Valiasr Hosp, Tabriz, Iran.
   [Jafari-Vayghan, Hamed] Arak Univ Med Sci, Sch Hlth, Dept Nutr, Arak, Iran.
   [Shivappa, Nitin; Hebert, James R.] Univ South Carolina, Arnold Sch Publ Hlth, Dept Epidemiol & Biostat, Columbia, SC 29208 USA.
   [Shivappa, Nitin; Hebert, James R.] Univ South Carolina, Arnold Sch Publ Hlth, Canc Prevent & Control Program, Columbia, SC 29208 USA.
C3 Tabriz University of Medical Science; Tabriz University of Medical
   Science; Tabriz University of Medical Science; Luxembourg Institute of
   Health; Tabriz University of Medical Science; University of South
   Carolina System; University of South Carolina Columbia; University of
   South Carolina System; University of South Carolina Columbia
RP Jafari-Vayghan, H (corresponding author), Arak Univ Med Sci, Sch Hlth, Dept Nutr, Arak, Iran.
EM hamedjafari65@gmail.com
RI Jafari-Vayghan, Hamed/AAF-7775-2019; Saleh-Ghadimi, Sevda/ABD-2355-2021;
   Hebert, James/IUO-5628-2023; Shivappa, Nitin/X-2215-2018;
   Almasi-Hashiani, Amir/P-3356-2018; Vahid, Farhad/L-7547-2018; Dehghan,
   Parvin/G-3885-2015
OI Vahid, Farhad/0000-0002-7380-3790; Dehghan, Parvin/0000-0001-8929-3302
FU Student Research Committee, Tabriz University of Medical Sciences
   [65792]
FX The research protocol was approved and supported by Student Research
   Committee, Tabriz University of Medical Sciences (grant number: 65792).
   The funding body played no role in the design of the study and
   collection, analysis, and interpretation of data and in writing the
   manuscript.
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NR 84
TC 21
Z9 21
U1 7
U2 21
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2458
J9 BMC PUBLIC HEALTH
JI BMC Public Health
PD AUG 9
PY 2022
VL 22
IS 1
AR 1513
DI 10.1186/s12889-022-13879-2
PG 12
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA 3Q2QF
UT WOS:000838077700003
PM 35945535
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Spencer, C
   Reed, RG
   Votruba-Drzal, E
   Gianaros, PJ
AF Spencer, Chrystal
   Reed, Rebecca G.
   Votruba-Drzal, Elizabeth
   Gianaros, Peter J.
TI Psychological Stress and the Longitudinal Progression of Subclinical
   Atherosclerosis
SO HEALTH PSYCHOLOGY
LA English
DT Article
DE psychological stress; subclinical atherosclerosis; carotid intima-medial
   thickness; cardiometabolic risk
ID INTIMA-MEDIA THICKNESS; RISK-FACTORS; CARDIOVASCULAR-DISEASE; CAROTID
   ATHEROSCLEROSIS; MYOCARDIAL-INFARCTION; ENDOTHELIAL FUNCTION; PERCEIVED
   STRESS; HEALTH BEHAVIORS; MENTAL STRESS; MORTALITY
AB Objective: In a midlife sample of adults, the present study tested the extent to which changes in psychological stress relate to the progression of subclinical cardiovascular disease over multiple years and explored the potential moderating role of cardiometabolic risk. Method: Participants were screened to exclude those with clinical cardiovascular, respiratory, metabolic, and other chronic illnesses, as well as those taking psychotropic, cardiovascular, lipid, and glucose control medications. At baseline (N = 331) and then again at follow-up an average of 3 years later (N = 260), participants completed the 10-item Perceived Stress Scale, underwent assessments of their cardiometabolic risk, and underwent ultrasonography to measure carotid artery intima-media thickness (IMT), which is a surrogate indicator of subclinical atherosclerosis. Results: Regression models showed that the change in psychological stress from baseline to follow-up was positively associated with the corresponding change in IMT, with covariate control for age at baseline, sex at birth, and variability in length of follow-up across participants. Cardiometabolic risk factors did not statistically moderate this longitudinal association. In exploratory analyses, cardiometabolic risk factors also did not statistically mediate this association. Conclusion: These longitudinal findings suggest that increases in psychological stress in midlife relate to corresponding increases in subclinical atherosclerosis.
C1 [Spencer, Chrystal; Reed, Rebecca G.; Votruba-Drzal, Elizabeth; Gianaros, Peter J.] Univ Pittsburgh, Dept Psychol, Pittsburgh, PA USA.
   [Spencer, Chrystal] Univ Pittsburgh, Dept Psychol, Old Engn Hall,3943 Ohara St, Pittsburgh, PA 15213 USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE); University
   of Pittsburgh; Pennsylvania Commonwealth System of Higher Education
   (PCSHE); University of Pittsburgh
RP Spencer, C (corresponding author), Univ Pittsburgh, Dept Psychol, Old Engn Hall,3943 Ohara St, Pittsburgh, PA 15213 USA.
EM chrystal.spencer@pitt.edu
RI Reed, Rebecca/GMW-6485-2022
OI Spencer, Chrystal/0000-0001-7105-7141
FU National Institutes of Health (NHLBI) [P01-HL040962, T32-HL07560]
FX This work was supported by the National Institutes of Health
   (NHLBIP01-HL040962 and T32-HL07560). The authors have no conflicts of
   interest to report. All data, scripts, and output are publicly available
   on the Open Science Framework
   (https://osf.io/jdrzt/?view_only=9209f1d97c0b455fb2d30f457db8f871).
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NR 67
TC 3
Z9 3
U1 2
U2 9
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 0278-6133
EI 1930-7810
J9 HEALTH PSYCHOL
JI Health Psychol.
PD JAN
PY 2024
VL 43
IS 1
BP 58
EP 66
DI 10.1037/hea0001333
EA NOV 2023
PG 9
WC Psychology, Clinical; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology
GA HH7J5
UT WOS:001108531600001
PM 37917469
OA hybrid
DA 2025-06-11
ER

PT J
AU Ceïde, ME
   Williams, NJ
   Seixas, A
   Longman-Mills, SK
   Jean-Louis, G
AF Ceide, Mirnova E.
   Williams, Natasha J.
   Seixas, Azizi
   Longman-Mills, Samantha K.
   Jean-Louis, Girardin
TI Obstructive sleep apnea risk and psychological health among non-Hispanic
   blacks in the Metabolic Syndrome Outcome (MetSO) cohort study
SO ANNALS OF MEDICINE
LA English
DT Article
DE Metabolic syndrome; non-Hispanic blacks; obstructive sleep apnea;
   psychological health
ID NUTRITION EXAMINATION SURVEY; DEPRESSIVE SYMPTOMS; AFRICAN-AMERICANS;
   NATIONAL-HEALTH; ANXIETY; POPULATION; PREVALENCE; DISORDER; OBESITY;
   ASSOCIATION
AB Introduction This study assessed associations of depression and anxiety with risk of obstructive sleep apnea (OSA) among non-Hispanic blacks in the Metabolic Syndrome Outcome (MetSO) study.
   Method A total of 1,035 patients participated. ARES TM score >= 6 defined high OSA risk. Moderate depression was defined by a CES-D score >= 16. Moderate anxiety was measured by a BAI score >= 16.
   Results The mean age was 62 +/- 14 years; 70% were female. A total of 93% were diagnosed with hypertension; 61%, diabetes; and 72%, dyslipidemia; 90% were overweight/obese; 33% had a history of heart disease; and 10% had a stroke. Logistic regression analysis, adjusting for age and gender, showed that patients with depression had nearly two-fold increased odds of being at risk for OSA (OR 1.75, 95% CI 1.02-2.98, p < 0.05). Patients with anxiety had three-fold increased odds of being at risk for OSA (OR 3.30, 95% CI 2.11-5.15, p < 0.01). After adjusting for marital status and income, patients with anxiety had a 6% increase in OSA risk (OR 1.06, 95% CI 1.04-1.09, p < 0.05), but depression was no longer significant.
   Conclusion Our results suggest that non-Hispanic blacks with metabolic syndrome who experience anxiety and/or depression should be screened for OSA.
C1 [Ceide, Mirnova E.] Montefiore Med Ctr, Dept Psychiat & Behav Sci, Bronx, NY 10467 USA.
   [Williams, Natasha J.; Seixas, Azizi; Jean-Louis, Girardin] NYU, Med Ctr, Dept Populat Hlth, Ctr Healthful Behav Change,Div Hlth & Behav, New York, NY 10016 USA.
   [Longman-Mills, Samantha K.] Univ W Indies, Dept Community Hlth & Psychiat, Mona, Jamaica.
C3 Montefiore Medical Center; Albert Einstein College of Medicine; New York
   University; University West Indies Mona Jamaica
RP Ceïde, ME (corresponding author), Montefiore Med Ctr, 111 East 210 St, Bronx, NY 10467 USA.
EM mirnova@gmail.com
OI Seixas, Azizi/0000-0003-0843-2679; Jean-Louis,
   Girardin/0000-0001-6777-2724
FU National Institutes of Health [R25HL105444, R01HL095799, RO1MD004113,
   U54NS081765]
FX This research was supported by funding from the National Institutes of
   Health: R25HL105444, R01HL095799, RO1MD004113, and U54NS081765. The
   funding source had no role in the design, conduct, or analysis of the
   study, or in the decision to submit the manuscript for publication.
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NR 55
TC 9
Z9 10
U1 0
U2 8
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0785-3890
EI 1365-2060
J9 ANN MED
JI Ann. Med.
PY 2015
VL 47
IS 8
BP 687
EP 693
DI 10.3109/07853890.2015.1107186
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA CY7LT
UT WOS:000366590600007
PM 26593384
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Cinar, N
   Kizilarslanoglu, MC
   Harmanci, A
   Aksoy, DY
   Bozdag, G
   Demir, B
   Yildiz, BO
AF Cinar, Nese
   Kizilarslanoglu, Muhammed Cemal
   Harmanci, Ayla
   Aksoy, Duygu Yazgan
   Bozdag, Gurkan
   Demir, Basaran
   Yildiz, Bulent Okan
TI Depression, anxiety and cardiometabolic risk in polycystic ovary
   syndrome
SO HUMAN REPRODUCTION
LA English
DT Article
DE depressive disorder; metabolic syndrome; polycystic ovary; obesity;
   diabetes
ID QUALITY-OF-LIFE; IMPAIRED GLUCOSE-TOLERANCE; METABOLIC SYNDROME;
   QUESTIONNAIRE PCOSQ; WOMEN; PREVALENCE; DISORDERS; OBESITY
AB BACKGROUND: Polycystic ovary syndrome (PCOS) is associated with psychological and metabolic disturbances. The aim of this study was to determine whether depression, anxiety and reduced health-related quality of life (HRQOL) are more common in women with PCOS and associated with metabolic risk.
   METHODS: The study included 226 PCOS patients and 85 BMI-matched healthy control women. All participants completed standardized questionnaires assessing depression (Beck Depression Inventory), anxiety (State-Trait Anxiety Inventory) and both depression and anxiety (Hospital Anxiety and Depression Scale and General Health Questionnaire). Patients also completed a PCOS HRQOL questionnaire. Hirsutism scores, serum androgens and lipids were obtained. All subjects underwent a standard oral glucose tolerance test.
   RESULTS: 28.6% of PCOS women versus 4.7% of control women had clinical depression scores indicating an 8.1-fold increased risk of depression in PCOS (P < 0.001). Depression and anxiety scores were higher in PCOS women than controls (P < 0.01 for all subscales). Obese PCOS subjects had higher depression scores and rates than non-obese PCOS women (P < 0.05). Depression scores were significantly correlated with insulin resistance and lipid parameters and with the number of components comprising the metabolic syndrome. Menstrual and hirsutism problems were the most serious concerns followed by emotional problems on the HRQOL.
   CONCLUSIONS: Depression and anxiety are more common in patients with PCOS compared with healthy women. Depression in PCOS might be associated with obesity and metabolic abnormalities including insulin resistance and dyslipidemia.
C1 [Cinar, Nese; Harmanci, Ayla; Aksoy, Duygu Yazgan; Yildiz, Bulent Okan] Hacettepe Univ, Sch Med, Dept Internal Med, Endocrinol & Metab Unit, TR-06100 Ankara, Turkey.
   [Bozdag, Gurkan] Hacettepe Univ, Sch Med, Dept Obstet & Gynecol, TR-06100 Ankara, Turkey.
   [Demir, Basaran] Hacettepe Univ, Sch Med, Dept Psychiat, TR-06100 Ankara, Turkey.
C3 Hacettepe University; Hacettepe University; Hacettepe University
RP Yildiz, BO (corresponding author), Hacettepe Univ, Sch Med, Dept Internal Med, Endocrinol & Metab Unit, TR-06100 Ankara, Turkey.
EM yildizbo@yahoo.com
RI AKSOY, DUYGU/ABI-6817-2020; Yildiz, Bulent/ABD-7781-2020
OI Demir, Basaran/0000-0002-7494-7075; Kizilarslanoglu, Muhammet
   Cemal/0000-0002-7632-6811; Yildiz, Bulent/0000-0003-1797-7662
CR Adali E, 2008, J INT MED RES, V36, P1188, DOI 10.1177/147323000803600604
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NR 43
TC 106
Z9 115
U1 1
U2 21
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0268-1161
EI 1460-2350
J9 HUM REPROD
JI Hum. Reprod.
PD DEC
PY 2011
VL 26
IS 12
BP 3339
EP 3345
DI 10.1093/humrep/der338
PG 7
WC Obstetrics & Gynecology; Reproductive Biology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Obstetrics & Gynecology; Reproductive Biology
GA 848NJ
UT WOS:000297058000017
PM 21984577
OA Bronze
DA 2025-06-11
ER

PT J
AU Capizzi, JA
   Allen, GJ
   Murphy, D
   Pescatello, LS
AF Capizzi, Jeffrey A.
   Allen, George J.
   Murphy, Donna
   Pescatello, Linda S.
TI The Interactive Effects of Metabolic Syndrome, Blood Pressure, and
   Mental Health in Worksite Employees
SO PHYSICIAN AND SPORTSMEDICINE
LA English
DT Article
DE metabolic syndrome; hypertension; sympathetic nervous system; baroreflex
ID CARDIOVASCULAR RISK-FACTORS; AMERICAN-HEART-ASSOCIATION;
   STRESS-MANAGEMENT; NATIONAL-HEALTH; NERVOUS-SYSTEM; JOB STRAIN;
   DEPRESSION; DISEASE; ANXIETY; HYPERTENSION
AB Background: Cardiovascular disease (CVD), CVD-related conditions, and mental health disorders are prevalent in the US work-force. We examined associations between metabolic syndrome (METS), blood pressure (BP), and mental health indicators in 1813 employees (25.4% women; 74.6% men) from a large manufacturing firm. Methods: Employees participated in a health screen. Biometric measures were body mass index, waist circumference, BP, and fingerstick determinations of blood lipid-lipoproteins and glucose. Mental health was assessed with 5 self-reported questions regarding anger, depression, anxiety, and family and work stress. Multivariate analysis of covariance tested for differences in BP and mental health indicators in employees (370 employees with METS, and 1443 employees without). Results: Participants were primarily middle-aged (44.8 +/- 0.3 years), overweight (27.9 +/- 0.1 kg/m(2)) men (n = 1352) and women (n = 461) with a resting BP of 122.5 +/- 0.3 mm Hg and 79.8 +/- 0.2 mm Hg, respectively. Diastolic BP (DBP) was found to be 5 mm Hg higher in men with METS compared with men who did not have METS. When questioned, men with higher DBP stated that they oft en experienced anxiety (n = 39; 91.0 +/- 2 mm Hg) compared with men who reported they rarely experienced anxiety (n = 112; 86.2 +/- 1.9 mm Hg) (P = 0.020). Similarly, systolic BP (SBP) tended to be 4 mm Hg higher in men with METS who stated they oft en experienced anxiety (n = 39; 138.9 +/- 2 mm Hg) compared with men who reported they rarely experienced anxiety (n = 112; 134.5 +/- 1.2 mm Hg) (P = 0.119). Diastolic BP tended to be 2 mm Hg higher among men with METS who stated they oft en experienced anger (n = 117; 89.4 +/- 0.9 mm Hg) compared with those who indicated they rarely experienced anger (n = 157; 87.3 +/- 0.8 mm Hg) (P = 0.086), and DBP was 3 mm Hg higher in men with METS who reported overwhelming work stress (n = 83; 89.7 +/- 1.1 mm Hg) compared with those reporting little work stress (n = 79; 86.6 +/- 1.2 mm Hg) (P = 0.176). In contrast, no associations were found between BP and mental health in men without METS, and in women, regardless of the presence or absence of METS (P > 0.05). Conclusions: Men with METS who reported higher levels of anxiety, anger, and work stress had higher BP than men without METS, who also reported lower levels of these mental health indicators. The METS appeared to adversely interact with BP and mental health in men at this worksite. Our findings suggest worksite health promotion programs can improve the cardiometabolic and mental health profile of US employees.
C1 [Capizzi, Jeffrey A.; Allen, George J.; Pescatello, Linda S.] Univ Connecticut, Storrs, CT USA.
   [Murphy, Donna] New Britain Gen Hosp, New Britain, CT USA.
C3 University of Connecticut
RP Capizzi, JA (corresponding author), Hartford Hosp, 85 Jefferson St,Suite 704, Hartford, CT 06102 USA.
EM jcapizzi@harthosp.org
RI Allen, George/HTN-6029-2023
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   2005, HLTH STATUS US WORKF
NR 52
TC 9
Z9 9
U1 0
U2 7
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0091-3847
EI 2326-3660
J9 PHYSICIAN SPORTSMED
JI Physician Sportsmed.
PD APR
PY 2010
VL 38
IS 1
BP 45
EP 53
DI 10.3810/psm.2010.04.1761
PG 9
WC Primary Health Care; Orthopedics; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine; Orthopedics; Sport Sciences
GA 766SO
UT WOS:000290807000005
PM 20424401
DA 2025-06-11
ER

PT J
AU von Känel, R
   Mausbach, BT
   Dimsdale, JE
   Mills, PJ
   Patterson, TL
   Ancoli-Israel, S
   Ziegler, MG
   Roepke, SK
   Harmell, AL
   Allison, M
   Grant, I
AF von Kaenel, Roland
   Mausbach, Brent T.
   Dimsdale, Joel E.
   Mills, Paul J.
   Patterson, Thomas L.
   Ancoli-Israel, Sonia
   Ziegler, Michael G.
   Roepke, Susan K.
   Harmell, Alexandrea L.
   Allison, Matthew
   Grant, Igor
TI Regular Physical Activity Moderates Cardiometabolic Risk in Alzheimer's
   Caregivers
SO MEDICINE & SCIENCE IN SPORTS & EXERCISE
LA English
DT Article
DE ALZHEIMER'S DISEASE; CARDIOVASCULAR DISEASE; EXERCISE; METABOLIC
   SYNDROME; PSYCHOLOGICAL STRESS
ID CORONARY-HEART-DISEASE; METABOLIC SYNDROME; CARDIOVASCULAR-DISEASE;
   CHRONIC STRESS; DEMENTIA CAREGIVERS; HEALTH BEHAVIORS; LIFE-STYLE;
   EXERCISE; WOMEN; SCORE
AB VON KANEL, R., B. T. MAUSBACH, J. E. DIMSDALE, P. J. MILLS, T. L. PATTERSON, S. ANCOLI-ISRAEL, M. G. ZIEGLER, S. K. ROEPKE, A. L. HARMELL, M. ALLISON, and I. GRANT. Regular Physical Activity Moderates Cardiometabolic Risk in Alzheimer's Caregivers. Med. Sci. Sports Exerc., Vol. 43, No. 1, pp. 181-189, 2011. Introduction: Dementia caregivers have an increased risk of cardiovascular disease, and it is possible that metabolic disturbances contribute to this risk. Regular physical exercise reduces cardiometabolic risk, but caregivers may have less opportunity to engage in such activity. We hypothesized that regular physical activity would moderate cardiometabolic risk in dementia caregivers. Methods: One hundred and fifteen Alzheimer's caregivers and 54 noncaregiving controls were assessed for medical history and health habits. Physical activity was defined as the number of days per week participants performed light (score = 0-4), moderate (score = 0-4), or vigorous (score = 0-4) exercise (total score = 0-12). A cardiometabolic risk score was calculated by adding standardized z-scores of five metabolic syndrome components: body mass index, triglycerides, HDL cholesterol, systolic blood pressure, and glucose. Results: Caregivers were less physically active than noncaregivers (mean +/- SD - 5.1 +/- 3.0 vs 6.3 +/- 2.7, P - 0.008). A significant caregiver status x physical activity interaction was found for the standardized cardiometabolic risk score controlling for gender, age, education, smoking, alcohol consumption, health problems, cholesterol-lowering medication, negative affect, role overload, and fasting state (P = 0.035). Among participants with low levels of physical activity, caregivers had greater cardiometabolic risk score than noncaregivers (0.58 +/- 0.31 vs -1.23 +/- 0.54, P = 0.017); no group difference emerged in participants with high levels of physical activity (P = 0.81). Conclusions: Cardiometabolic risk was particularly high in caregivers reporting reduced levels of regular physical activity. Intervention studies aimed at increasing physical activity in caregivers seem warranted to examine whether that would possibly lower cardiometabolic risk to the level of noncaregivers.
C1 [von Kaenel, Roland] Univ Bern, Inselspital, Univ Hosp Bern, Div Psychosomat Med,Dept Gen Internal Med, CH-3010 Bern, Switzerland.
   [von Kaenel, Roland; Mausbach, Brent T.; Dimsdale, Joel E.; Mills, Paul J.; Patterson, Thomas L.; Ancoli-Israel, Sonia; Harmell, Alexandrea L.; Grant, Igor] Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA.
   [Ziegler, Michael G.] Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA.
   [Roepke, Susan K.] Univ Calif San Diego, San Diego State Univ, Joint Doctoral Program Clin Psychol, La Jolla, CA 92093 USA.
   [Allison, Matthew] Univ Calif San Diego, Dept Family & Prevent Med, La Jolla, CA 92093 USA.
C3 University of Bern; University Hospital of Bern; University of
   California System; University of California San Diego; University of
   California System; University of California San Diego; University of
   California System; University of California San Diego; California State
   University System; San Diego State University; University of California
   System; University of California San Diego
RP von Känel, R (corresponding author), Univ Bern, Inselspital, Univ Hosp Bern, Div Psychosomat Med,Dept Gen Internal Med, CH-3010 Bern, Switzerland.
EM roland.vonkaenel@insel.ch
RI Ziegler, Michael/L-4728-2019; von Kanel, Roland/B-1811-2019
OI Mausbach, Brent/0000-0003-2884-8743; Allison,
   Matthew/0000-0003-0777-8272; von Kanel, Roland/0000-0002-8929-5129
FU National Institutes of Health/National Institute on Aging [AG 15301, AG
   03090, AG 108415]
FX The authors are grateful to Susan Calleran and Christine Gonzaga for
   data collection. This study was supported by the National Institutes of
   Health/National Institute on Aging through award AG 15301 to Igor Grant.
   Additional support was provided through award AG 03090 to Brent Mausbach
   and AG 108415 to Sonia Ancoli-Israel.
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NR 41
TC 25
Z9 28
U1 1
U2 22
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0195-9131
EI 1530-0315
J9 MED SCI SPORT EXER
JI Med. Sci. Sports Exerc.
PD JAN
PY 2011
VL 43
IS 1
BP 181
EP 189
DI 10.1249/MSS.0b013e3181e6d478
PG 9
WC Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Sport Sciences
GA 695YW
UT WOS:000285410000023
PM 20473220
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Tuason, MTG
   Ancheta, IB
   Battie, CA
AF Tuason, Ma Teresa G.
   Ancheta, Irma B.
   Battie, Cynthia A.
TI What Impacts the Psychological Health of Filipino American Women?
SO ASIAN AMERICAN JOURNAL OF PSYCHOLOGY
LA English
DT Article
DE Filipino American women; biological health risks; depression; anxiety;
   discrimination
ID CARDIOVASCULAR RISK-FACTORS; METABOLIC SYNDROME; SOCIOECONOMIC-STATUS;
   PREVALENCE; IMMIGRANTS; DEPRESSION; DISCRIMINATION; BEHAVIOR; DISEASE;
   ANXIETY
AB The researchers investigated psychological health (i.e., levels of depression, anxiety, experiences of discrimination, and self mastery) in a Filipino American sample. Filipino Americans experience health disparities (Nadal, 2011) as they underutilize counseling services when they may have high rates of psychiatric disorders (e.g., Gong, Gage, & Tacata, 2003), and have high risk in terms of cardiovascular disease (Ye, Rust, Baltrus, & Daniels, 2009). Filipino American Women (FAW) specifically, have high rates of metabolic syndrome (MetS) prevalence (Ancheta, Battie, Tuason, & Ancheta, 2012), and diabetes mellitus (e.g., Araneta, Wingard, & Barrett-Connor, 2002). Using the biopsychosocial model, this study aimed to identify which biological risk indicators differentiate FAW's psychological health, and to investigate which best predict their psychological health. In this cross-sectional study of FAW (N = 377), demographic information, clinical measurements (e.g., hemoglobin A1C, serum glucose, blood pressure) and responses to 5 questionnaires were obtained. Results show that controlling for age, FAW with MetS and those without MetS did not report differences in depressive symptomatology, anxiety, experiences of discrimination, and self-mastery. Other biological risk conditions, such as obesity, waist circumference, high blood pressure, and family history of heart disease did not differentiate FAW's psychological health. Multiple regression analyses revealed that lower income and level of education are significant predictors of depression and anxiety, and higher income and education are significant predictors of self-mastery, more than any biological health variable. Findings highlight the interconnection between biological, demographic, and psychological variables in a minority population.
C1 [Tuason, Ma Teresa G.; Battie, Cynthia A.] Univ N Florida, Dept Publ Hlth, Jacksonville, FL 32224 USA.
   [Ancheta, Irma B.] Univ Florida, Dept Med, Jacksonville, FL USA.
C3 State University System of Florida; University of North Florida; State
   University System of Florida; University of Florida
RP Tuason, MTG (corresponding author), Univ N Florida, Dept Publ Hlth, 1 UNF Dr, Jacksonville, FL 32224 USA.
EM ttuason@unf.edu
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NR 45
TC 8
Z9 18
U1 0
U2 14
PU EDUCATIONAL PUBLISHING FOUNDATION-AMERICAN PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST, NE, WASHINGTON, DC 20002-4242 USA
SN 1948-1985
EI 1948-1993
J9 ASIAN AM J PSYCHOL
JI Asian Am. J. Psychol.
PD DEC
PY 2014
VL 5
IS 4
BP 307
EP 315
DI 10.1037/a0037781
PG 9
WC Ethnic Studies; Psychology, Multidisciplinary
WE Social Science Citation Index (SSCI)
SC Ethnic Studies; Psychology
GA AX9QH
UT WOS:000347236500004
DA 2025-06-11
ER

PT J
AU Chhabria, K
   Selvaraj, S
   Refuerzo, J
   Truong, C
   Cazaban, CG
AF Chhabria, Karishma
   Selvaraj, Sudhakar
   Refuerzo, Jerrie
   Truong, Chau
   Cazaban, Cecilia Ganduglia
TI Investigating the association between metabolic syndrome conditions and
   perinatal mental illness: a national administrative claims study
SO BMC PREGNANCY AND CHILDBIRTH
LA English
DT Article
DE Perinatal comorbidities; Maternal mental health; Administrative claims
   data; Metabolic syndrome
ID PREGNANCY; DEPRESSION; HEALTH; INFLAMMATION; COMORBIDITY; MECHANISMS;
   DISORDERS; EPISODES; OBESITY; WOMEN
AB Background Although the association between mental disorder and metabolic syndrome as a bidirectional relationship has been demonstrated, there is little knowledge of the cumulative and individual effect of these conditions on peripartum mental health. This study aims to investigate the association between metabolic syndrome conditions (MetS-C) and maternal mental illness in the perinatal period, while exploring time to incident mental disorder diagnosis in postpartum women.Methods This observational study identified perinatal women continuously enrolled 1 year prior to and 1 year post-delivery using Optum's de-identified Clinformatics (R) Data Mart Database (CDM) from 2014 to 2019 with MetS-C i.e. obesity, diabetes, high blood pressure, high triglycerides, or low HDL (1-year prior to delivery); perinatal comorbidities (9-months prior to and 4-month postpartum); and mental disorder (1-year prior to and 1-year post-delivery). Additionally, demographics and the number of days until mental disorder diagnosis were evaluated in this cohort. The analysis included descriptive statistics and multivariable logistic regression. MetS-C, perinatal comorbidities, and mental disorder were assessed using the International Classification of Diseases, Ninth, and Tenth Revision diagnosis codes.Results 372,895 deliveries met inclusion/exclusion criteria. The prevalence of MetS-C was 13.43%. Multivariable logistic regression revealed prenatal prevalence (1.64, CI = 1.59-1.70) and postpartum incident (1.30, CI = 1.25-1.34) diagnosis of mental health disorder were significantly higher in those with at least one MetS-C. Further, the adjusted odds of having postpartum incident mental illness were 1.51 times higher (CI = 1.39-1.66) in those with 2 MetS-C and 2.12 times higher (CI = 1.21-4.01) in those with 3 or more MetS-C. Young women (under the age of 18 years) were more likely to have an incident mental health diagnosis as opposed to other age groups. Lastly, time from hospital discharge to incident mental disorder diagnosis revealed an average of 157 days (SD = 103 days).Conclusion The risk of mental disorder (both prenatal and incident) has a significant association with MetS-C. An incremental relationship between incident mental illness diagnosis and the number of MetS-C, a significant association with younger mothers along with a relatively long period of diagnosis mental illness highlights the need for more screening and treatment during pregnancy and postpartum.
C1 [Chhabria, Karishma; Truong, Chau; Cazaban, Cecilia Ganduglia] Univ Texas Hlth Sci Ctr Houston, Ctr Healthcare Data Res, Sch Publ Hlth, Div Management Policy & Community Hlth, Houston, TX 77030 USA.
   [Chhabria, Karishma] Univ West Florida, Usha Kundu MD Coll Hlth, Dept Publ Hlth, 11000 Univ Pkwy, Pensacola, FL 32514 USA.
   [Selvaraj, Sudhakar] Univ Texas Hlth Sci Ctr Houston, McGovern Med Sch, Dept Psychiat & Behav Sci, Houston, TX USA.
   [Refuerzo, Jerrie] Univ Texas Hlth Sci Ctr Houston, McGovern Med Sch, Dept Obstet Gynecol & Reprod Sci, Div Maternal Fetal Med, Houston, TX USA.
   [Selvaraj, Sudhakar] Intra Cellular Therapies Inc, Clin Dev, 430 East 29th St, New York, NY USA.
C3 University of Texas System; University of Texas Health Science Center
   Houston; University of Texas School Public Health; State University
   System of Florida; University of West Florida; Baylor College of
   Medicine; Baylor College Medical Hospital; University of Texas System;
   University of Texas Health Science Center Houston; University of Texas
   System; University of Texas Health Science Center Houston
RP Chhabria, K (corresponding author), Univ Texas Hlth Sci Ctr Houston, Ctr Healthcare Data Res, Sch Publ Hlth, Div Management Policy & Community Hlth, Houston, TX 77030 USA.; Chhabria, K (corresponding author), Univ West Florida, Usha Kundu MD Coll Hlth, Dept Publ Hlth, 11000 Univ Pkwy, Pensacola, FL 32514 USA.
EM kchhabria@uwf.edu
RI selvaraj, sudhakar/G-1450-2011
OI Chhabria Unrue, Karishma/0000-0001-5028-023X
FU NIMH [1R21MH119441-01A1, 1R21MH129888-01A1]; NICHD [1R21HD106779-01A1];
   Don and Anne Fizer Foundation; University of Texas Health Science center
   at Houston (UTHealth) faculty research supplement funds (SS)
FX Dr. Sudhakar Selvaraj has received grants/research support from NIMH
   (1R21MH119441-01A1), NIMH (1R21MH129888-01A1), NICHD (1R21HD106779-01A1)
   and Don and Anne Fizer Foundation. The University of Texas Health
   Science center at Houston (UTHealth) faculty research supplement funds
   (SS) were utilized for this study. The institution played no role in the
   design and conduct of the study; collection, management, analysis, and
   interpretation of the data; preparation, review, or approval of the
   manuscript; and decision to submit the manuscript for publication.
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NR 49
TC 0
Z9 0
U1 0
U2 0
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2393
J9 BMC PREGNANCY CHILDB
JI BMC Pregnancy Childbirth
PD JUN 7
PY 2024
VL 24
IS 1
AR 409
DI 10.1186/s12884-024-06542-8
PG 9
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA TW6Y8
UT WOS:001244348400004
PM 38849738
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Castle, D
   Li, A
AF Castle, David
   Li, Amy
TI Physical health monitoring for people with schizophrenia
SO AUSTRALIAN PRESCRIBER
LA English
DT Article
DE antipsychotics; cardiometabolic risk; hyperprolactinaemia; metabolic
   syndrome; obesity schizophrenia
ID OBSTRUCTIVE SLEEP-APNEA; AUSTRALIAN NATIONAL-SURVEY; RISK-FACTORS;
   ANTIPSYCHOTIC-DRUGS; MENTAL-ILLNESS; EPIDEMIOLOGY; DISORDERS; SMOKING
AB Schizophrenia is a severe psychiatric disorder associated with significant comorbidities and early mortality.People with schizophrenia have a greater predisposition to the top 6 modifiable global mortality (cardiometabolic) risk factors as defined by the World Health Organization (compared with the general population). These are driven by genetic, lifestyle and disease factors, and obesogenic antipsychotic medications.Smoking, obesity and type 2 diabetes are the most important modifiable cardiometabolic risk factors for cardiovascular disease in people with schizophrenia.Enhanced physical health screening, especially for cardiometabolic risk factors, is recommended for people with schizophrenia.A multidisciplinary holistic approach is recommended for treating people with schizophrenia, using contact with primary care practitioners to review their physical health.
C1 [Castle, David] Univ Tasmania, Hobart, Australia.
   [Li, Amy] Monash Univ, Clayton, Vic, Australia.
C3 University of Tasmania; Monash University
RP Castle, D (corresponding author), Univ Tasmania, Hobart, Australia.
RI li, amy/KGL-5437-2024
OI Castle, David/0000-0002-3075-1580
FU Research Future Fund; Barbara Dicker Foundation; Canadian Institute for
   Health Information, Brain Canada; Boehringer Ingelheim; isa part owner
   (5%) of Clarity Healthcare
FX Research Future Fund, Barbara Dicker Foundation, Canadian Institute for
   Health Information, Brain Canada, Servier and Boehringer Ingelheim. He
   has also received travel support and honoraria for presentations and
   consultancy from Servier, Seqirus, Lundbeck, Mindcafe, Psychscene and
   Inside Practice. He was a co-author of the Royal Australian and New
   Zealand College of Psychiatrists clinical practice guidelines for the
   management of schizophrenia and related disorders (2016) , and an author
   on Being Equally Well (2021) . He founded the Optimal Health Program and
   holds 50% of its intellectual property, and isa part owner (5%) of
   Clarity Healthcare.
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NR 35
TC 3
Z9 3
U1 0
U2 2
PU Therapeutic Guidelines Ltd
PI North Melbourne
PA 133 Abbotsford St, North Melbourne, Victoria, AUSTRALIA
SN 0312-8008
EI 1839-3942
J9 AUST PRESCR
JI Aust. Prescr.
PD DEC
PY 2023
VL 46
IS 4
BP 75
EP 79
DI 10.18773/austprescr.2023.024
PG 5
WC Pharmacology & Pharmacy
WE Emerging Sources Citation Index (ESCI)
SC Pharmacology & Pharmacy
GA FN2I9
UT WOS:001146438800004
PM 38152317
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Mohsenpour, MA
   Mohammadi, F
   Sohrabi, Z
   Niakousari, M
   Jeddi, M
   Eftekhari, MH
AF Mohsenpour, Mohammad Ali
   Mohammadi, Farzaneh
   Sohrabi, Zahra
   Niakousari, Mehrdad
   Jeddi, Marjan
   Eftekhari, Mohammad Hassan
TI Mental health and health-related quality of life response to
   curcumin-probiotic drink powder co-supplementation in adults with
   overweight/obesity and metabolic syndrome: a four-arm randomised,
   double-blind, placebo-controlled, clinical trial
SO BRITISH JOURNAL OF NUTRITION
LA English
DT Article; Early Access
DE Curcumin; Probiotic; Metabolic syndrome; Overweight; Obesity; Mental
   health; Quality of life
ID SURVEY SF-36; METAANALYSIS; DEPRESSION; ANXIETY; ASSOCIATION; OBESE
AB Metabolic syndrome (MetS) is associated with deteriorated mental health and health-related quality of life (HRQOL). Curcumin and probiotics improved MetS, mental health and HRQOL. The present study aimed to investigate the effect of curcumin-probiotic (CurPro) co-supplementation in the form of drink powder on mental health and HRQOL in adults with overweight/obesity and MetS. A four-arm, randomised, double-blinded, placebo-controlled clinical trial with factorial design was conducted for adults with overweight/obesity and MetS (n 128). Participants were randomly allocated into four groups to receive one drink powder sachet containing 1 g curcumin, 109 colony-forming unit (CFU) probiotic (Lactobacillus acidophilus and Lactobacillus rhamnosus strains), CurPro (1 g curcumin and 109 CFU probiotic) or placebo along with a low-calorie diet. Participants were assessed for dietary intake, physical activity, mental health and HRQOL before and after the study. After 8 weeks of intervention, 104 participants finished the study. The CurPro intervention reduced stress (P = 0<middle dot>001) and anxiety (P = 0<middle dot>019) and improved general health (P = 0<middle dot>024) and overall HRQOL (P = 0<middle dot>011) scores of participants in comparison with the Placebo group. Results were NS for depression and HRQOL subdomains such as physical functioning, role limitations due to physical problems, bodily pain, vitality, social functioning and role limitations due to emotional problems. Curcumin-probiotics co-supplementation could improve the mental health and HRQOL of adults with overweight/obesity and MetS. Further investigations in various populations or with different dosages or durations are recommended.
C1 [Mohsenpour, Mohammad Ali; Mohammadi, Farzaneh] Shiraz Univ Med Sci, Student Res Comm, Shiraz, Iran.
   [Mohsenpour, Mohammad Ali; Mohammadi, Farzaneh; Eftekhari, Mohammad Hassan] Shiraz Univ Med Sci, Sch Nutr & Food Sci, Dept Clin Nutr, Shiraz, Iran.
   [Sohrabi, Zahra] Shiraz Univ Med Sci, Nutr Res Ctr, Sch Nutr & Food Sci, Shiraz, Iran.
   [Niakousari, Mehrdad] Shiraz Univ, Coll Agr, Dept Food Sci & Technol, Shiraz, Iran.
   [Jeddi, Marjan] Shiraz Univ Med Sci, Endocrinol & Metab Res Ctr, Shiraz, Iran.
   [Eftekhari, Mohammad Hassan] Shiraz Univ Med Sci, Inst Hlth, Res Ctr Hlth Sci, Shiraz, Iran.
C3 Shiraz University of Medical Science; Shiraz University of Medical
   Science; Shiraz University of Medical Science; Shiraz University; Shiraz
   University of Medical Science; Tehran University of Medical Sciences;
   Shiraz University of Medical Science
RP Eftekhari, MH (corresponding author), Shiraz Univ Med Sci, Sch Nutr & Food Sci, Dept Clin Nutr, Shiraz, Iran.; Eftekhari, MH (corresponding author), Shiraz Univ Med Sci, Inst Hlth, Res Ctr Hlth Sci, Shiraz, Iran.
EM eftekharim@sums.ac.ir
RI Sohrabi, Zahra/R-4948-2017; Mohsenpour, Mohammad Ali/GYA-4997-2022;
   jedi, marjan/C-2825-2018
FU Vice-chancellor of Research of Shiraz University of Medical Sciences,
   Shiraz, Iran [26818]; Department of Food Sciences and Technology, Shiraz
   University;  [24422]
FX This study was a part of a major project and extracted from Mohammad Ali
   Mohsenpour's PhD dissertation in Nutrition (ID: 24422). The authors
   would like to thank the collaborators and participants of the study for
   taking part in this research. We send warm regards to the
   Vice-chancellor of Research of Shiraz University of Medical Sciences,
   Shiraz, Iran, for the financial support of the study (Grant number:
   26818). The research team thanks the Department of Food Sciences and
   Technology, Shiraz University, for the dedicated support in using
   laboratories and facilities.
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NR 57
TC 0
Z9 0
U1 0
U2 0
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1145
EI 1475-2662
J9 BRIT J NUTR
JI Br. J. Nutr.
PD 2025 MAY 16
PY 2025
DI 10.1017/S0007114525000923
EA MAY 2025
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 3FL2D
UT WOS:001499064800001
PM 40375569
DA 2025-06-11
ER

PT J
AU Penninx, BWJH
   Lange, SMM
AF Penninx, Brenda W. J. H.
   Lange, Sjors M. M.
TI Metabolic syndrome in psychiatric patients: overview, mechanisms, and
   implications
SO DIALOGUES IN CLINICAL NEUROSCIENCE
LA English
DT Article
DE abdominal obesity; bipolar disorder; cardiovascular disease; depression;
   dyslipidemia; metabolic syndrome; review; schizophrenia
ID MAJOR DEPRESSIVE DISORDER; BIPOLAR DISORDER; MENTAL-ILLNESS;
   CARDIOVASCULAR RISK; ANTIDEPRESSANT USE; CARDIOMETABOLIC RISK;
   ANTIPSYCHOTIC-DRUGS; GENERAL-POPULATION; PHYSICAL-ACTIVITY;
   CONTROLLED-TRIAL
AB Psychiatric patients have a greater risk of premature mortality, predominantly due to cardiovascular diseases (CVDs). Convincing evidence shows that psychiatric conditions are characterized by an increased risk of metabolic syndrome (MetS), a clustering of cardiovascular risk factors including dyslipidemia, abdominal obesity, hypertension, and hyperglycemia. This increased risk is present for a range of psychiatric conditions, including major depressive disorder (MDD), bipolar disorder (BD), schizophrenia, anxiety disorder, attention-deficit/hyperactivity disorder (ADHD), and posttraumatic stress disorder (PTSD). There is some evidence for a dose-response association with the severity and duration of symptoms and for a bidirectional longitudinal impact between psychiatric disorders and MetS. Associations generally seem stronger with abdominal obesity and dyslipidemia dysregulations than with hypertension. Contributing mechanisms are an unhealthy lifestyle and a poor adherence to medical regimen, which are prevalent among psychiatric patients. Specific psychotropic medications have also shown a profound impact in increasing MetS dysregulations. Finally, pleiotropy in genetic vulnerability and pathophysiological mechanisms, such as those leading to the increased central and peripheral activation of immunometabolic or endocrine systems, plays a role in both MetS and psychiatric disorder development The excess risk of MetS and its unfavorable somatic health consequences justifies a high priority for future research, prevention, close monitoring, and treatment to reduce MetS in the vulnerable psychiatric patient. (C) 2018, AICH - Servier Research Group
C1 Vrije Univ Amsterdam Med Ctr, Dept Psychiat, Amsterdam, Netherlands.
   GGZ InGeest, Amsterdam, Netherlands.
C3 Vrije Universiteit Amsterdam; VU UNIVERSITY MEDICAL CENTER
RP Penninx, BWJH (corresponding author), Vrije Univ Amsterdam Med Ctr, Oldenaller 1, Amsterdam, Netherlands.
EM b.penninx@vumc.nl
RI Penninx, Brenda/S-7627-2017
OI Lange, Sjors/0000-0002-3843-9372
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NR 77
TC 360
Z9 374
U1 2
U2 33
PU INST CONFERENCE HIPPOCRATE
PI SURESNESS-CEDEX
PA 50 RUE CARNOT, SURESNESS-CEDEX, 92284, FRANCE
SN 1294-8322
EI 1958-5969
J9 DIALOGUES CLIN NEURO
JI Dialogues Clin. Neurosci.
PD APR
PY 2018
VL 20
IS 1
BP 63
EP +
PG 11
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology
GA GL4PD
UT WOS:000437135200009
PM 29946213
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Min, SH
   Docherty, SL
   Im, EO
   Yang, Q
AF Min, Se Hee
   Docherty, Sharron L.
   Im, Eun-Ok
   Yang, Qing
TI Identification of Symptom Clusters Among Midlife Menopausal Women with
   Metabolic Syndrome
SO WESTERN JOURNAL OF NURSING RESEARCH
LA English
DT Article
DE Menopause; Obesity; Quality of life; Symptom management; Women's health
ID EXPLORATORY FACTOR-ANALYSIS; QUALITY-OF-LIFE; VASOMOTOR SYMPTOMS;
   MENTAL-HEALTH; TRANSITION; PREVALENCE; DEPRESSION; ANXIETY; ASSOCIATION;
   SLEEP
AB The aim of this study was to identify and compare symptom clusters in midlife menopausal women with and without metabolic syndrome based on symptom occurrence and severity dimension through secondary data analysis of the Study of Women's Health Across the Nation. Exploratory factor analysis was used to group symptoms that are highly correlated with each other and verified by confirmatory factor analysis. Midlife menopausal women with metabolic syndrome (n = 424) experienced mental health, vasomotor, and somatic cluster across both symptom dimensions. In contrast, midlife menopausal women without metabolic syndrome (n = 1022) experienced mental health/sleep/urinary, vasomotor, and somatic cluster for symptom occurrence dimension and mental health/sleep, vasomotor/genital, and somatic cluster for symptom severity dimension. This is the first study to identify symptom clusters in midlife menopausal women with metabolic syndrome, who are at risk for experiencing complex symptoms associated with menopause transition and metabolic syndrome, and to compare symptom clusters to those without metabolic syndrome.
C1 [Min, Se Hee; Docherty, Sharron L.; Yang, Qing] Duke Univ, Sch Nursing, 307 Trent Dr, Durham, NC 27710 USA.
   [Im, Eun-Ok] Emory Univ, Nell Hodgson Woodruff Sch Nursing, Atlanta, GA 30322 USA.
C3 Duke University; Emory University
RP Min, SH (corresponding author), Duke Univ, Sch Nursing, 307 Trent Dr, Durham, NC 27710 USA.
EM sehee.min@duke.edu
OI Min, Se Hee/0000-0003-2722-6627; Yang, Qing/0000-0003-4844-4690
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NR 61
TC 7
Z9 8
U1 0
U2 21
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0193-9459
EI 1552-8456
J9 WESTERN J NURS RES
JI West. J. Nurs. Res.
PD SEP
PY 2022
VL 44
IS 9
BP 838
EP 853
AR 01939459211018824
DI 10.1177/01939459211018824
EA MAY 2021
PG 16
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA 3O2LA
UT WOS:000656013700001
PM 34039103
DA 2025-06-11
ER

PT J
AU Alciati, A
   Gesuele, F
   Casazza, G
   Foschi, D
AF Alciati, Alessandra
   Gesuele, Felice
   Casazza, Giovanni
   Foschi, Diego
TI The Relationship between Childhood Parental Loss and Metabolic Syndrome
   in Obese Subjects
SO STRESS AND HEALTH
LA English
DT Article
DE metabolic syndrome; psychological stress; obesity; body mass index;
   psychiatric diagnosis
ID PSYCHIATRIC-DISORDER; INSULIN-RESISTANCE; BIPOLAR DISORDER; MAJOR
   DEPRESSION; RISK-FACTORS; LIFE; STRESS; CORTISOL; SPECTRUM; WEIGHT
AB The increasing global trend of obesity is a fundamental contributor to the growing prevalence of metabolic syndrome, a cluster of medical abnormalities including impaired glucose and lipid metabolism, obesity and hypertension. Results from animal and human investigations have shown that early life stress can result in weight gain and metabolic changes. Our aim is to investigate whether a particular type of an early adverse event, i.e. parental loss during childhood, is associated with the development of metabolic syndrome in severely obese subjects. One hundred thirty-five consecutive obese patients who were seeking bariatric surgery were assessed for metabolic syndrome according to the Adult Treatment Panel (ATP) III criteria. Information regarding the experience of parental separation or bereavement before the age of 17 was collected with the use of a semi-structured interview. In our population, 31.1% of the subjects met the criteria for metabolic syndrome. No significant differences in demographic factors, health habits or psychiatric diagnosis were found between patients with and without coexisting metabolic syndrome. After adjusting for age and gender, multivariate logistic regression analysis revealed that both childhood loss of a parent and a body mass index (BMI) value greater than 50 were significant predictors of metabolic syndrome. This study provides preliminary evidence linking childhood parental loss to risk factors for the development of metabolic syndrome. Copyright (c) 2011 John Wiley & Sons, Ltd.
C1 [Alciati, Alessandra; Gesuele, Felice] Luigi Sacco Univ Hosp, Dept Psychiat, I-20157 Milan, Italy.
   [Casazza, Giovanni] Univ Milan, Dipartimento Med Lavoro, Milan, Italy.
   [Foschi, Diego] Luigi Sacco Univ Hosp, Dept Surg, I-20157 Milan, Italy.
C3 University of Milan; Luigi Sacco Hospital; University of Milan;
   University of Milan; Luigi Sacco Hospital
RP Alciati, A (corresponding author), Luigi Sacco Univ Hosp, Dept Psychiat, Via GB Grassi 75, I-20157 Milan, Italy.
EM alessandra.alciati@libero.it
RI Alciati, Alessandra/M-2298-2019; Casazza, Giovanni/G-3661-2012; Foschi,
   Diego/K-7248-2017
OI Casazza, Giovanni/0000-0003-3718-1784; Alciati,
   Alessandra/0000-0002-8971-4696; Foschi, Diego/0000-0002-7702-8226
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NR 58
TC 29
Z9 30
U1 0
U2 34
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1532-3005
EI 1532-2998
J9 STRESS HEALTH
JI Stress Health
PD FEB
PY 2013
VL 29
IS 1
BP 5
EP 13
DI 10.1002/smi.1435
PG 9
WC Psychology, Applied; Psychiatry; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA 083NY
UT WOS:000314472500003
PM 22190357
DA 2025-06-11
ER

PT J
AU Kim, T
   Nam, GE
   Han, B
   Cho, SJ
   Kim, J
   Eum, DH
   Lee, SW
   Min, SH
   Lee, W
   Han, K
   Park, YG
AF Kim, Taeryoon
   Nam, Ga Eun
   Han, Byoungduck
   Cho, Sung Jung
   Kim, Junghun
   Eum, Do Hyun
   Lee, Sang Woo
   Min, Soon Hong
   Lee, Woohyun
   Han, Kyungdo
   Park, Yong Gyu
TI Associations of mental health and sleep duration with menstrual cycle
   irregularity: a population-based study
SO ARCHIVES OF WOMENS MENTAL HEALTH
LA English
DT Article
DE Menstrual cycle irregularity; Stress; Depressive mood; Suicidal
   ideation; Sleep duration
ID CARDIOMETABOLIC RISK; SUICIDAL-BEHAVIOR; CANCER RISK; DEPRESSION;
   SYMPTOMS; QUALITY; WOMEN
AB This study aimed to examine whether the characteristics of mental health and sleep duration, alone or in combination, are associated with menstrual cycle irregularity. This population-based, cross-sectional study analyzed the data from 4445 women aged 19-49 years, who participated in the Korea National Health and Nutrition Examination Survey 2010-2012. A structured questionnaire was used to assess mental health characteristics, sleep duration, and menstrual cycle irregularity. A multivariable logistic regression analysis was performed. High stress, depressive mood, and suicidal ideation were associated with increased risk of menstrual cycle irregularity after adjusting for confounding variables (odds ratio [95% confidence interval] = 1.33 [1.07-1.65], 1.56 [1.17-2.07], and 1.37 [1.01-1.87], respectively). Short sleep duration (<= 5 h a day) was significantly associated with higher odds of severe menstrual cycle irregularity with menstrual interval of greater than 3 months (2.67 [1.35-5.27]). Participants with sleep duration of = 5 h a day with psychological stress, depressive mood, or suicidal ideation had higher odds of menstrual cycle irregularity (1.96 [1.26-3.05], 2.86 [1.50-5.44], and 2.25 [1.18-4.29]). This study suggests positive associations of mental health problems and short sleep duration with menstrual cycle irregularity among Korean female adults. Therefore, strategies to deal with psychological stress, depressive mood, and sleep duration are needed for improving the reproductive health of women suffering from menstrual disturbances.
C1 [Kim, Taeryoon; Nam, Ga Eun; Han, Byoungduck; Cho, Sung Jung; Kim, Junghun; Eum, Do Hyun; Lee, Sang Woo; Min, Soon Hong; Lee, Woohyun] Sahmyook Med Ctr, Dept Family Med, 82 Mangu Ro, Seoul 02500, South Korea.
   [Han, Kyungdo; Park, Yong Gyu] Catholic Univ Korea, Coll Med, Dept Biostat, 222 Banpo Daero, Seoul 06591, South Korea.
C3 Catholic University of Korea
RP Nam, GE (corresponding author), Sahmyook Med Ctr, Dept Family Med, 82 Mangu Ro, Seoul 02500, South Korea.; Park, YG (corresponding author), Catholic Univ Korea, Coll Med, Dept Biostat, 222 Banpo Daero, Seoul 06591, South Korea.
EM namgaaa@daum.net; ygpark@catholic.ac.kr
RI lee, sangwoo/KUD-1906-2024; Nam, Ga Eun/AAU-6055-2020
OI Nam, Ga Eun/0000-0002-6739-9904; han, byoungduck/0000-0003-2830-1174
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NR 28
TC 29
Z9 30
U1 1
U2 19
PU SPRINGER WIEN
PI WIEN
PA SACHSENPLATZ 4-6, PO BOX 89, A-1201 WIEN, AUSTRIA
SN 1434-1816
EI 1435-1102
J9 ARCH WOMEN MENT HLTH
JI Arch. Womens Ment. Health
PD DEC
PY 2018
VL 21
IS 6
BP 619
EP 626
DI 10.1007/s00737-018-0872-8
PG 8
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA HA7ZU
UT WOS:000450507000004
PM 29909508
DA 2025-06-11
ER

PT J
AU Botker, HE
AF Botker, HE
TI Vascular and metabolic abnormalities in patients with angina pectoris
   and normal coronary angiograms
SO DANISH MEDICAL BULLETIN
LA English
DT Review
ID POSITRON-EMISSION TOMOGRAPHY; MYOCARDIAL BLOOD-FLOW; INSULIN-RESISTANCE
   SYNDROME; CARDIAC SYNDROME-X; LEFT-VENTRICULAR FUNCTION; CARDIOLOGICAL
   SYNDROME-X; EXERCISE-INDUCED ANGINA; ST-SEGMENT DEPRESSION; TERM
   FOLLOW-UP; CHEST PAIN
C1 Skejby Hosp, Dept Cardiol, DK-8200 Aarhus N, Denmark.
   Aarhus Univ Hosp, Aarhus Kommune Hosp, Dept Internal Med, DK-8000 Aarhus, Denmark.
   Aarhus Univ Hosp, Aarhus Kommune Hosp, PET Ctr, DK-8000 Aarhus, Denmark.
C3 Aarhus University; Aarhus University; Aarhus University
RP Skejby Hosp, Dept Cardiol B, DK-8200 Aarhus N, Denmark.
RI Bøtker, Hans Erik/AFB-5630-2022
OI Botker, Hans Erik/0000-0001-6358-8962
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NR 183
TC 2
Z9 2
U1 0
U2 0
PU DANISH MEDICAL ASSOC
PI COPENHAGEN
PA TRONDHJEMSGADE 9, DK-2100 COPENHAGEN, DENMARK
SN 0907-8916
EI 1603-9629
J9 DAN MED BULL
JI Dan. Med. Bull.
PD FEB
PY 2001
VL 48
IS 1
BP 1
EP 18
PG 18
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 409NW
UT WOS:000167390600001
PM 11258147
DA 2025-06-11
ER

PT J
AU Sahin, M
   Yüzügüllü, D
AF Sahin, Musa
   Yuzugullu, Didem
TI Outcomes of metabolic syndrome and anxiety levels in light and heavy
   smokers
SO PEERJ
LA English
DT Article
DE Metabolic syndrome; Dose-response; Smoking status; Tobacco-related
   disease; State trait anxiety inventory
ID CIGARETTE-SMOKING; NICOTINE DEPENDENCE; PHYSICAL-ACTIVITY; ASSOCIATION;
   STRESS; DEPRESSION; CESSATION; WOMEN; RISK; PREVENTION
AB Background: This study aimed to assess the impact of smoking status, as measured by pack-years (PY), on components of metabolic syndrome while considering the influence of anxiety. Design: This cross-sectional study was conducted at a smoking cessation clinic in Turkey, enrolling individuals who visited the clinic in 2022. The Fagerstrom Test for Nicotine Dependence and the State-Trait Anxiety Inventory were utilized as assessment tools, while metabolic syndrome parameters (body mass index, hypertension, hyperglycemia, dyslipidemia) were evaluated. Smoking status was classified based on pack-years. Results: The study revealed a dose-dependent relationship between smoking status and essential metabolic factors such as systolic blood pressure (SBP), diastolic blood pressure (DBP), hemoglobin A1c (HbA1c), and low-density lipoprotein (LDL). Notably, triglyceride (TG) levels exhibited a significant increase, particularly at 25 pack years. While anxiety levels did not exhibit a significant correlation with smoking status, they demonstrated an upward trend with increasing SBP and DBP values. Anxiety levels did not exhibit a significant correlation with smoking status. Conclusions: A significant association was identified between nicotine addiction, as indicated by PY, and both metabolic syndrome parameters and anxiety levels. Early smoking cessation is strongly recommended for current smokers, and former smokers are advised to abstain from smoking to mitigate its adverse effects on metabolic syndrome components. These findings underscore the interconnectedness of cigarette smoking's effects on both physical and mental health, emphasizing the necessity of comprehensive approaches encompassing both metabolic disorder management and mental health support within cessation programs.
C1 [Sahin, Musa; Yuzugullu, Didem] Minist Hlth Turkiye, Prov Hlth Directorate Adana, Adana, Turkiye.
RP Sahin, M (corresponding author), Minist Hlth Turkiye, Prov Hlth Directorate Adana, Adana, Turkiye.
EM dr.musasahin@hotmail.com
RI SAHIN, Musa/U-4073-2018; Yüzügüllü, Didem/GPP-5935-2022
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NR 66
TC 0
Z9 0
U1 1
U2 1
PU PEERJ INC
PI LONDON
PA 341-345 OLD ST, THIRD FLR, LONDON, EC1V 9LL, ENGLAND
SN 2167-8359
J9 PEERJ
JI PeerJ
PD MAR 5
PY 2025
VL 13
AR e19069
DI 10.7717/peerj.19069
PG 20
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 1YO0I
UT WOS:001476700300001
PM 40061234
OA gold
DA 2025-06-11
ER

PT J
AU Yoo, H
   Franke, WD
AF Yoo, Hyelim
   Franke, Warren D.
TI Sleep Habits, Mental Health, and the Metabolic Syndrome in Law
   Enforcement Officers
SO JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
LA English
DT Article
ID CARDIOVASCULAR-DISEASE MORBIDITY; NUTRITION EXAMINATION SURVEY;
   RISK-FACTOR; POLICE OFFICERS; INSULIN-RESISTANCE; PERCEIVED STRESS;
   QUALITY INDEX; LONG-SLEEP; DURATION; MORTALITY
AB Objective: To assess the association of sleep characteristics and mental health with the metabolic syndrome (MetS) in law enforcement officers (LEOs). Methods: Sleep duration (<= 6, >6-<8, >= 8 hours/night), sleep quality ("good," "poor"), mental health (stress, burnout, depression), and MetS components were compared in 106 LEOs. Results: The prevalence of MetS was 33%. After covariate adjustment including the mental health measures, long sleep duration was associated with MetS (odds ratio = 4.89, 95% confidence interval = 1.32 to 18.13), whereas sleep quality was not. LEOs with short sleep duration or poor sleep quality reported more stress, burnout, and depression symptoms. Conclusions: In LEOs, sleep duration is more strongly associated with the occurrence of MetS than sleep quality, independent of mental health. Nevertheless, short sleep duration and poor sleep quality may affect mental health in LEOs.
C1 [Yoo, Hyelim; Franke, Warren D.] Iowa State Univ, Dept Kinesiol, Ames, IA USA.
C3 Iowa State University
RP Franke, WD (corresponding author), 247 Forker Bldg, Ames, IA 50011 USA.
EM wfranke@iastate.edu
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NR 43
TC 35
Z9 46
U1 0
U2 7
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1076-2752
EI 1536-5948
J9 J OCCUP ENVIRON MED
JI J. Occup. Environ. Med.
PD JAN
PY 2013
VL 55
IS 1
BP 111
EP 115
DI 10.1097/JOM.0b013e31826e294c
PG 5
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA 068TL
UT WOS:000313389000015
PM 23207742
DA 2025-06-11
ER

PT J
AU Robinson, DJ
   Coons, M
   Haensel, H
   Vallis, M
   Yale, JF
AF Robinson, David J.
   Coons, Michael
   Haensel, Heidi
   Vallis, Michael
   Yale, Jean-Francois
TI Diabetes and Mental Health
SO CANADIAN JOURNAL OF DIABETES
LA English
DT Article
ID QUALITY-OF-LIFE; PSYCHOLOGICAL INSULIN-RESISTANCE;
   POSTTRAUMATIC-STRESS-DISORDER; COGNITIVE-BEHAVIOR THERAPY; IMPROVE
   GLYCEMIC CONTROL; FAMILY SYSTEMS THERAPY; CO-MORBID DEPRESSION;
   METABOLIC SYNDROME; EMOTIONAL DISTRESS; DOUBLE-BLIND
RI Vallis, Michael/R-8965-2019
OI Vallis, Michael/0000-0002-0165-5936
FU Eli Lilly Canada; Sanofi; Merck; AstraZeneca; Boehringer Ingelheim;
   Janssen; Medtronic; Novo Nordisk; Takeda; Abbott; Bayer; Mylan
FX Dr. Robinson reports personal fees from Janssen, Otsuka, Lundbeck, and
   Allergan, outside the submitted work. Dr. Coons has received honoraria
   from the Canadian Medical and Surgical Knowledge Translation Working
   Group. Dr. Vallis reports personal fees from Novo Nordisk, Valeant,
   Sanofi, Pfizer, CSL Behring, Merck, and Abbvie, outside the submitted
   work. Dr. Yale reports grants and personal fees from Eli Lilly Canada,
   Sanofi, Merck, AstraZeneca, Boehringer Ingelheim, Janssen, and
   Medtronic; personal fees from Novo Nordisk, Takeda, Abbott, and Bayer;
   and grants from Mylan. No other author has anything to disclose.
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NR 230
TC 122
Z9 130
U1 0
U2 11
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1499-2671
EI 2352-3840
J9 CAN J DIABETES
JI Can. J. Diabetes
PD APR
PY 2018
VL 42
SU S
BP S130
EP S141
DI 10.1016/j.jcjd.2017.10.031
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA GM5EL
UT WOS:000438154400018
PM 29650085
OA hybrid
DA 2025-06-11
ER

PT J
AU Hatton-Jones, K
   Cox, AJ
   Peart, JN
   Headrick, JP
   du Toit, EF
AF Hatton-Jones, Kyle
   Cox, Amanda J.
   Peart, Jason N.
   Headrick, John P.
   du Toit, Eugene F.
TI Stress-induced body weight loss and improvements in cardiometabolic risk
   factors do not translate to improved myocardial ischemic tolerance in
   western diet-fed mice
SO PHYSIOLOGICAL REPORTS
LA English
DT Article
DE anxiety-like behavior; cardiometabolic risk; chronic stress; myocardial
   ischemia; restraint stress; diet; western diet
ID CHRONIC RESTRAINT STRESS; HIGH-FAT DIET; CHRONIC PSYCHOLOGICAL STRESS;
   CHRONIC MILD STRESS; OPEN-FIELD ACTIVITY; FOOD-INTAKE;
   INSULIN-RESISTANCE; GLUCOSE-TOLERANCE; INDUCED OBESITY; 52 COUNTRIES
AB Although both diet-induced obesity and psychological stress are recognized as significant independent contributors to cardiometabolic and behavioral disorders, our understanding of how these two disorders interact and influence cardiometabolic risk and myocardial ischemic tolerance is limited. The aim of this study was to assess the combined effects of an obesogenic diet and psychological stress on cardiometabolic risk factors (body weight, dyslipidemia, insulin sensitivity) and postischemic cardiovascular outcomes. C57Bl/6J mice (n = 48) were subject to a combination of 22 weeks of western diet (WD) feeding and chronic restraint stress (CRS) for the last 4 weeks. Metabolic and behavioral changes were assessed using glucose tolerance tests and open field tests (OFTs), respectively. After 22 weeks, cardiac function and ischemic tolerance were assessed in Langendorff perfused hearts. WD feeding increased body weight and worsened blood lipids and insulin sensitivity. WD-fed mice also exhibited reduced exploratory behavior within the OFT. CRS reduced body weight and increased locomotion in both dietary groups and had differential effects on fasting glucose metabolism in the two dietary groups while not impacting non-fasting insulin. Although the WD only marginally reduced reperfusion left ventricular developed pressure recovery, CRS worsened reperfusion diastolic dysfunction in both dietary groups. Interestingly, despite WD+CRS animals exhibiting improved cardiometabolic parameters compared to the WD group, these changes did not translate to marked improvements to postischemic cardiac outcomes. In conclusion, in this study, combined WD feeding and CRS did not act synergistically to worsen cardiometabolic risk factors but instead improved them. Despite these cardiometabolic improvements, WD+CRS increased reperfusion end diastolic pressure which may be indicative of worsened ischemia/reperfusion injury.
C1 [Hatton-Jones, Kyle; Cox, Amanda J.; Peart, Jason N.; Headrick, John P.; du Toit, Eugene F.] Griffith Univ, Sch Pharm & Med Sci, Southport, Qld 4217, Australia.
C3 Griffith University; Griffith University - Gold Coast Campus
RP du Toit, EF (corresponding author), Griffith Univ, Sch Pharm & Med Sci, Southport, Qld 4217, Australia.
EM j.dutoit@griffith.edu.au
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NR 80
TC 4
Z9 4
U1 2
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2051-817X
J9 PHYSIOL REP
JI PHYSIOL. REP.
PD JAN
PY 2022
VL 10
IS 2
AR e15170
DI 10.14814/phy2.15170
PG 16
WC Physiology
WE Emerging Sources Citation Index (ESCI)
SC Physiology
GA YN6ZS
UT WOS:000747405400010
PM 35076176
OA Green Published
DA 2025-06-11
ER

PT J
AU Conte, F
   Banting, L
   Teede, HJ
   Stepto, NK
AF Conte, Francesca
   Banting, Lauren
   Teede, Helena J.
   Stepto, Nigel K.
TI Mental Health and Physical Activity in Women with Polycystic Ovary
   Syndrome: A Brief Review
SO SPORTS MEDICINE
LA English
DT Review
ID QUALITY-OF-LIFE; OBESE WOMEN; CARDIOMETABOLIC RISK; QUESTIONNAIRE PCOSQ;
   INSULIN-RESISTANCE; OVERWEIGHT WOMEN; EXERCISE; PREVALENCE; DEPRESSION;
   ANXIETY
AB This review was designed to consider the available literature concerning mental health and physical activity in women with polycystic ovary syndrome (PCOS). A systematic approach was taken and two electronic databases (PubMed and EBSCO Research articles published between 1970 and 2013) were searched in 2013 to inform a narrative review. Inclusion criteria encompassed requirements for the research to involve a physical activity intervention and assessment of mental health outcomes in women with PCOS. Seven articles considered mental health outcomes and physical activity interventions for women with PCOS. The results demonstrated positive outcomes following physical activity intervention for health-related quality of life, depression, and anxiety. Only one paper reported the independent effects of physical activity on mental health. All other interventions included multi-factor lifestyle interventions or did not establish a control group. Physical activity is likely to be beneficial to the mental health of women with PCOS; however, more research is required to establish the nature of the relationship between physical activity and mental health outcomes.
C1 [Conte, Francesca; Banting, Lauren; Stepto, Nigel K.] Victoria Univ, Inst Sport Exercise & Act Living, Melbourne, Vic 8001, Australia.
   [Conte, Francesca] Univ Padua, UOC Sports Med, Dept Med, Padua, Italy.
   [Teede, Helena J.; Stepto, Nigel K.] Monash Univ, Sch Publ Hlth & Prevent Med, Monash Ctr Hlth Res & Implementat, Clayton, Vic 3168, Australia.
   [Teede, Helena J.] Monash Hlth, Diabet & Vasc Med Unit, Clayton, Vic 3168, Australia.
C3 Victoria University; University of Padua; Monash University; Monash
   Health
RP Stepto, NK (corresponding author), Victoria Univ, Inst Sport Exercise & Act Living, Footscray Pk Campus,POB 14428, Melbourne, Vic 8001, Australia.
EM nigel.stepto@vu.edu.au
OI Stepto, Nigel/0000-0002-0875-6836; Teede, Helena/0000-0001-7609-577X
FU Australian Government Collaborative Research Network scheme
FX A/Prof Stepto is supported by the Australian Government Collaborative
   Research Network scheme. Prof Teede is an NHMRC Practitioner Fellow.
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NR 61
TC 36
Z9 38
U1 2
U2 28
PU ADIS INT LTD
PI NORTHCOTE
PA 5 THE WAREHOUSE WAY, NORTHCOTE 0627, AUCKLAND, NEW ZEALAND
SN 0112-1642
EI 1179-2035
J9 SPORTS MED
JI Sports Med.
PD APR
PY 2015
VL 45
IS 4
BP 497
EP 504
DI 10.1007/s40279-014-0291-6
PG 8
WC Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Sport Sciences
GA CE9LI
UT WOS:000352165100004
PM 25430602
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Vourdoumpa, A
   Paltoglou, G
   Manou, M
   Mantzou, E
   Kassari, P
   Papadopoulou, M
   Kolaitis, G
   Charmandari, E
AF Vourdoumpa, Aikaterini
   Paltoglou, George
   Manou, Maria
   Mantzou, Emilia
   Kassari, Penio
   Papadopoulou, Marina
   Kolaitis, Gerasimos
   Charmandari, Evangelia
TI Improvement in Symptoms of Depression and Anxiety and Cardiometabolic
   Risk Factors in Children and Adolescents with Overweight and Obesity
   Following the Implementation of a Multidisciplinary Personalized
   Lifestyle Intervention Program
SO NUTRIENTS
LA English
DT Article
DE childhood obesity; mental health; depression; anxiety; lifestyle
   intervention
ID BODY-MASS INDEX; PSYCHOMETRIC PROPERTIES; CHILDHOOD OBESITY;
   TESTOSTERONE; METAANALYSIS; DISORDERS; SCREEN; ASSOCIATIONS; PREVENTION;
   PATHWAYS
AB Background/Objectives: Childhood obesity is one of the most challenging contemporary public health problems. Children and adolescents with obesity experience multiple psychosocial difficulties, such as low self-esteem, depression, anxiety, and behavioral problems, which persist for a long time. The aim of the study was to assess the effect of a multidisciplinary personalized lifestyle intervention for depressive and anxiety symptoms, as evaluated by psychometric questionnaires, and their effect and association with cardiometabolic parameters in children and adolescents with overweight and obesity before and after the intervention. Methods: Six hundred and eleven (n = 611) children and adolescents (mean age +/- SE: 10.39 +/- 0.10 years; 51.5% females, 46.6% pubertal) were studied prospectively. Subjects were classified as being obese (50.2%), overweight (33.5%), or having a normal BMI (16.2%) according to IOTF criteria. All participants entered a 1-year lifestyle intervention program; laboratory investigations were obtained at the beginning and end of the study and two psychometric questionnaires were completed, the CDI and SCARED, which evaluate symptoms of depression and anxiety, respectively. Results: Following the lifestyle intervention, a significant decrease was noted in anxiety scores in all subjects and in depression scores in youth with obesity, as well as in adolescents with obesity, while females displayed a reduced response to the intervention. Insulin resistance and metabolic syndrome parameters, cortisol, PRL, and LH concentrations were positive predictors for depressive and anxiety symptoms. Conclusions: The implementation of a multidisciplinary personalized lifestyle intervention program in the management of childhood obesity is associated with a significant decrease in cardiometabolic and psychosocial comorbidities in children with and without excess adiposity. The improvement in mental health is likely mediated by an improvement in energy metabolism with subsequent improvement in neuroinflammation owing to lifestyle changes.
C1 [Vourdoumpa, Aikaterini; Manou, Maria; Mantzou, Emilia; Kassari, Penio; Papadopoulou, Marina; Charmandari, Evangelia] Natl & Kapodistrian Univ, Aghia Sophia Childrens Hosp, Dept Pediat 1, Div Endocrinol Metab & Diabet,Athens Med Sch, Athens 11527, Greece.
   [Paltoglou, George] Natl & Kapodistrian Univ Athens, P&A Kyriakou Childrens Hosp, Dept Pediat 2, Diabet & Metab Clin, Athens 11527, Greece.
   [Kassari, Penio; Charmandari, Evangelia] Biomed Res Fdn Acad Athens, Ctr Clin Expt Surg & Translat Res, Athens 11527, Greece.
   [Kolaitis, Gerasimos] Natl & Kapodistrian Univ, Aghia Sophia Childrens Hosp, Dept Child Psychiat, Athens Med Sch, Athens 11527, Greece.
C3 National & Kapodistrian University of Athens; The Aghia Sophia
   Children's Hospital; National & Kapodistrian University of Athens;
   Academy of Athens; National & Kapodistrian University of Athens; The
   Aghia Sophia Children's Hospital
RP Charmandari, E (corresponding author), Natl & Kapodistrian Univ, Aghia Sophia Childrens Hosp, Dept Pediat 1, Div Endocrinol Metab & Diabet,Athens Med Sch, Athens 11527, Greece.; Charmandari, E (corresponding author), Biomed Res Fdn Acad Athens, Ctr Clin Expt Surg & Translat Res, Athens 11527, Greece.
EM katvourdouba@gmail.com; gpaltoglou@gmail.com; mariamanou93@hotmail.com;
   amantzou@med.uoa.gr; peniokassari@gmail.com; marinageorpap@gmail.com;
   gkolaitis@med.uoa.gr; evangelia.charmandari@googlemail.com
RI Charmandari, Evangelia/AAF-2038-2019; Paltoglou, George/B-6944-2019
OI Paltoglou, George/0000-0003-4300-7061; MANOU, MARIA/0000-0002-9584-0373
FU National Strategic Reference Framework (NSRF) [MIS 370545]; European
   Social Fund (ESF); European Regional Development Fund of the European
   Union [T1EDK-01386, 5030543]; Greek national funds through the
   operational program "Competitiveness, Entrepreneurship
FX The study has been co-financed by the (i) National Strategic Reference
   Framework (NSRF) 2007-2013 under the operational program "Human
   Resources Development" (EP.AN.A.D) 2007-2013 and was co-funded by the
   European Social Fund (ESF) and national funding (Program entitled
   "Development of a National System for the Prevention and Management of
   Overweight and Obesity in Childhood and Adolescence in Greece", with the
   promotional phrase "Lose Weight-Gain Life" (MIS 370545)); and (ii) the
   European Regional Development Fund of the European Union and Greek
   national funds through the operational program "Competitiveness,
   Entrepreneurship, and Innovation" (EPAnEK 2014-2020), under the call
   RESEARCH-CREATE-INNOVATE (project code: T1EDK-01386, MIS: 5030543,
   acronym: PEDOBESITY, program entitled "Development of Intelligent
   Multi-level Information Systems and Specialized Artificial Intelligence
   Algorithms for Personalized Management of Obesity in Childhood and
   Adolescence".
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NR 76
TC 0
Z9 0
U1 4
U2 6
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD NOV
PY 2024
VL 16
IS 21
AR 3710
DI 10.3390/nu16213710
PG 19
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA L6M0S
UT WOS:001351826900001
PM 39519542
OA gold
DA 2025-06-11
ER

PT J
AU Vassou, C
   Georgousopoulou, EN
   Chrysohoou, C
   Yannakoulia, M
   Pitsavos, C
   Cropley, M
   Panagiotakos, DB
AF Vassou, Christina
   Georgousopoulou, Ekavi N.
   Chrysohoou, Christina
   Yannakoulia, Mary
   Pitsavos, Christos
   Cropley, Mark
   Panagiotakos, Demosthenes B.
TI Psychological factors in relation to the 10-year incidence of metabolic
   syndrome: The ATTICA epidemiological study (2002-2012)
SO NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
LA English
DT Article
DE Metabolic syndrome; Irrational beliefs; Anxiety; Depression; Hostility
ID CARDIOVASCULAR-DISEASE INCIDENCE; IRRATIONAL BELIEFS; DEPRESSION;
   ANXIETY; ASSOCIATION; QUESTIONNAIRE; COGNITIONS; HOSTILITY; VALIDITY;
   MARKERS
AB Background and aims: Various bio-psychological mechanisms underlying the association between mental health problems and metabolic syndrome remain unknown. We investigated the role of irrational beliefs in conjunction with anxiety, depression and hostility in the 10-year metabolic syndrome (MetS) incidence, and the effect of biochemical and sociobehavioral factors on the aforementioned associations.Methods and results: ATTICA is a prospective, cohort study (2002-2012). The sample included 591 participants [51.3% men (aged 41.5 +/- 10 years) and 48.7% women (aged 37.5 +/- 11.5 years)], free of MetS at baseline. Detailed biochemical, clinical, and lifestyle evaluations were performed, while participants' irrational beliefs, anxiety, depression and hostility were assessed using the Irrational Beliefs Inventory, the Spielberger State-Trait Anxiety Inventory, the Zung Self-Rating Depression Scale and the Hostility and Direction of Hostility Questionnaire, respectively. Multiple logistic regression was applied to estimate the odds ratio (OR) of developing MetS and to control for confounders, as well as stratified logistic regression to detect moderator effects. High irrational beliefs were associated with 1.5-times higher odds of developing MetS than low irrational beliefs. Especially, participants with high irrational beliefs and high anxiety were 96% more likely to develop MetS, compared with those with low irrational beliefs and low or high anxiety (OR = 1.96; 95% CI = 1.01, 3.80).Conclusion: The findings of the study underline the important role of irrational beliefs and anxiety in the development of MetS and the need to build new holistic approaches focused on the primary prevention of both mental health and MetS.(c) 2022 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.
C1 [Vassou, Christina; Yannakoulia, Mary; Panagiotakos, Demosthenes B.] Harokopio Univ, Sch Hlth Sci & Educ, Dept Nutr & Dietet, Athens, Greece.
   [Georgousopoulou, Ekavi N.] Univ Notre Dame, Sch Med Sydney, Sydney, Australia.
   [Chrysohoou, Christina; Pitsavos, Christos] Univ Athens, Sch Med, Cardiol Clin 1, Athens, Greece.
   [Cropley, Mark] Univ Surrey, Sch Psychol, Guildford, Surrey, England.
   [Panagiotakos, Demosthenes B.] Univ Canberra, Fac Hlth, Canberra, Australia.
   [Panagiotakos, Demosthenes B.] Harokopio Univ, Sch Hlth Sci & Educ, Dept Nutr & Dietet, 70 Eleftheriou Venizelou Ave, Athens 17676, Greece.
C3 Harokopio University Athens; The University of Notre Dame Australia;
   Athens Medical School; National & Kapodistrian University of Athens;
   University of Surrey; University of Canberra; Harokopio University
   Athens
RP Panagiotakos, DB (corresponding author), Harokopio Univ, Sch Hlth Sci & Educ, Dept Nutr & Dietet, 70 Eleftheriou Venizelou Ave, Athens 17676, Greece.
EM dbpanag@hua.gr
RI Cropley, Mark/V-2296-2019; Vassou, Christina/HLX-0360-2023;
   Panagiotakos, Demosthenes/K-8294-2019; Georgousopoulou,
   Ekavi/AAC-2563-2019
OI Yannakoulia, Mary/0000-0003-2171-7337; Cropley,
   Mark/0000-0002-8483-1797; Georgousopoulou, Ekavi/0000-0002-0592-3838;
   Chrysohoou, Christina/0000-0002-6340-3996
FU Hellenic Cardiology Society [HCS2002, HAS2003]
FX The ATTICA study was supported by research grants from the Hellenic
   Cardiology Society [HCS2002] and the Hel- lenic Atherobiosclerosis
   Society [HAS2003] .
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NR 43
TC 2
Z9 3
U1 0
U2 0
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0939-4753
EI 1590-3729
J9 NUTR METAB CARDIOVAS
JI Nutr. Metab. Carbiovasc. Dis.
PD SEP
PY 2022
VL 32
IS 9
BP 2195
EP 2203
DI 10.1016/j.numecd.2022.05.011
EA AUG 2022
PG 9
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism; Nutrition
   & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism;
   Nutrition & Dietetics
GA 4X8UC
UT WOS:000861111900019
PM 35843796
DA 2025-06-11
ER

PT J
AU Hoge, EA
   Bui, E
   Palitz, SA
   Schwarz, NR
   Owens, ME
   Johnston, JM
   Pollack, MH
   Simon, NM
AF Hoge, Elizabeth A.
   Bui, Eric
   Palitz, Sophie A.
   Schwarz, Noah R.
   Owens, Maryann E.
   Johnston, Jennifer M.
   Pollack, Mark H.
   Simon, Naomi M.
TI The effect of mindfulness meditation training on biological acute stress
   responses in generalized anxiety disorder
SO PSYCHIATRY RESEARCH
LA English
DT Article
DE Meditation; Anxiety; Resilience; Stress reactivity; Acute stress;
   Mindfulness-based intervention; Psychological stress
ID RANDOMIZED CONTROLLED-TRIAL; CORONARY-HEART-DISEASE; ACUTE PSYCHOSOCIAL
   STRESS; PITUITARY-ADRENAL AXIS; COGNITIVE THERAPY; PSYCHOLOGICAL STRESS;
   CORTISOL RESPONSES; METABOLIC SYNDROME; MAJOR DEPRESSION; HEALTHY-MEN
AB Mindfulness-Based interventions have increased in popularity in psychiatry, but the impact of these treatments on disorder-relevant biomarkers would greatly enhance efficacy and mechanistic evidence. If Generalized Anxiety Disorder (GAD) is successfully treated, relevant biomarkers should change, supporting the impact of treatment and suggesting improved resilience to stress. Seventy adults with GAD were randomized to receive either Mindfulness-Based Stress Reduction (MBSR) or an attention control class; before and after, they underwent the Trier Social Stress Test (TSST). Area-Under-the-Curve (AUC) concentrations were calculated for adrenocorticotropic hormone (ACTH) and pro-inflammatory cytokines. MBSR participants had a significantly greater reduction in ACTH AUC compared to control participants. Similarly, the MBSR group had a greater reduction in inflammatory cytokines' AUC concentrations. We found larger reductions in stress markers for patients with GAD in the MBSR class compared to control; this provides the first combined hormonal and immunological evidence that MBSR may enhance resilience to stress.
C1 [Hoge, Elizabeth A.; Bui, Eric; Palitz, Sophie A.; Schwarz, Noah R.; Owens, Maryann E.; Simon, Naomi M.] Massachusetts Gen Hosp, Dept Psychiat, Ctr Anxiety & Traumat Stress Disorders, Boston, MA 02114 USA.
   [Hoge, Elizabeth A.] Georgetown Univ, Med Ctr, Dept Psychiat, Washington, DC 20007 USA.
   [Bui, Eric; Simon, Naomi M.] Harvard Med Sch, Boston, MA USA.
   [Johnston, Jennifer M.] Boston Univ, Sch Med, Dept Psychiat, Boston, MA 02118 USA.
   [Pollack, Mark H.] Rush Univ, Med Ctr, Dept Psychiat, Chicago, IL 60612 USA.
C3 Harvard University; Harvard University Medical Affiliates; Massachusetts
   General Hospital; Georgetown University; Harvard University; Harvard
   Medical School; Boston University; Rush University
RP Hoge, EA (corresponding author), Georgetown Univ, Med Ctr, Psychiat Res Div, 2115 Wisconsin Ave,Suite 120, Washington, DC 20007 USA.
EM eah103@georgetown.edu
RI Schwarz, Noah/B-8525-2015; Hoge, Elizabeth/H-5879-2012; Bui,
   Eric/J-8347-2015
OI Bui, Eric/0000-0002-1413-6473
FU Harvard Clinical and Translational Science Center (NIH) [UL1 RR 025758];
   Harvard University
FX The authors would like to thank Zayda Vallejo for her work in teaching
   the study courses, and the MGH hospital volunteers who assisted in this
   study, and to acknowledge nursing support from the Harvard Clinical and
   Translational Science Center (NIH Award #UL1 RR 025758 and financial
   contributions from Harvard University and its affiliated academic health
   care centers). The content is solely the responsibility of the authors
   and does not necessarily represent the official views of Harvard
   Catalyst, Harvard University and its affiliated academic health care
   centers, the National Center for Research Resources, or the National
   Institutes of Health.
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NR 39
TC 119
Z9 142
U1 5
U2 185
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0165-1781
J9 PSYCHIAT RES
JI Psychiatry Res.
PD APR
PY 2018
VL 262
BP 328
EP 332
DI 10.1016/j.psychres.2017.01.006
PG 5
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA GD6VN
UT WOS:000430646700047
PM 28131433
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Parastouei, K
   Nashtar, SB
   Al-Attar, Z
   Shekarchizadeh-Esfahani, P
   Askari, G
AF Parastouei, Karim
   Nashtar, Saad Badai
   Al-Attar, Zaid
   Shekarchizadeh-Esfahani, Parivash
   Askari, Gholamreza
TI The effects of jujube (Ziziphus jujube) on metabolic and
   mental health outcomes in patients with metabolic syndrome: A randomized
   controlled trial
SO COMPLEMENTARY THERAPIES IN MEDICINE
LA English
DT Article
DE Jujube; Ziziphus jujube; Metabolic syndrome; Functional food; Mental
   health
ID CONSTRUCT-VALIDITY; INSULIN-RESISTANCE; FUNCTIONAL FOODS; STRESS;
   PATHOPHYSIOLOGY; PREVALENCE; OBESITY; VERSION; FRUIT
AB Objectives: The effects of jujube (Ziziphus jujube) consumption on metabolic and mental health outcomes in subjects diagnosed with metabolic syndrome (MetS) is unknown and remains to be examined. Hence, we carried out a parallel-group, randomized controlled trial to investigate this issue. Methods: Eligible participants were randomly assigned to the intervention (n = 30) or the control (n = 30) groups to receive either jujube or a placebo for eight weeks. Subjects were provided with 30 g dried jujube powder or placebo and were asked to consume half of the powder at 10 a.m. and the rest at 4 p.m. Lipid profile, fasting blood glucose (FBG), waist circumference (WC), and blood pressure were evaluated as primary outcomes. Secondary outcomes collected were mental health measures (e.g., depression, anxiety, and stress). Results: Jujube consumption failed to decrease FBG, total cholesterol, low-density lipoprotein cholesterol, and blood pressure, as well as depression and anxiety scores (P > 0.05). However, the between-group comparison revealed a significant improvement in WC (- 3.98 vs. - 0.51, P = 0.01), triglyceride (TG) (- 24.96 vs. - 0.73, P = 0.03), and high-density lipoprotein cholesterol (HDL-C) (2.83 vs. 0.40, P = 0.01) in the jujube group compared to the placebo. In addition, compared to the control group, jujube consumption led to a significant improvement in the score of stress (- 5.80 vs. - 2.86, P = 0.01). Conclusion: Jujube consumption only had beneficial effects on WC, TG, and HDL-C in subjects with MetS. However, the current study has methodological weaknesses in blinding and herb purity/potency testing, which should be addressed in future studies.
C1 [Parastouei, Karim] Baqiyatallah Univ Med Sci, Life Style Inst, Hlth Res Ctr, Tehran, Iran.
   [Nashtar, Saad Badai; Al-Attar, Zaid] Univ Baghdad, Al Kindy Coll Med, Dept Pharmacol, Baghdad, Iraq.
   [Shekarchizadeh-Esfahani, Parivash] Isfahan Univ Med Sci, Sch Management & Med Informat Sci, Dept Gen Courses, Esfahan, Iran.
   [Askari, Gholamreza] Isfahan Univ Med Sci, Nutr & Food Secur Res Ctr, Sch Nutr & Food Sci, Dept Community Nutr, Esfahan, Iran.
C3 Baqiyatallah University of Medical Sciences (BMSU); University of
   Baghdad; Isfahan University of Medical Sciences; Isfahan University of
   Medical Sciences
RP Parastouei, K (corresponding author), Baqiyatallah Univ Med Sci, Life Style Inst, Hlth Res Ctr, Tehran, Iran.
EM parastouei@gmail.com
RI Badai Nashtar, Saad/HMP-6383-2023; Al-Attar, Zaid/M-6874-2019
OI Al-Attar, Zaid/0000-0002-0111-5382; Badai, Saad/0000-0001-9545-0204
FU Baqiyatallah University of Medical Sciences, Tehran, Iran
FX The present study was supported by Baqiyatallah University of Medical
   Sciences, Tehran, Iran.
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NR 52
TC 1
Z9 1
U1 4
U2 8
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0965-2299
EI 1873-6963
J9 COMPLEMENT THER MED
JI Complement. Ther. Med.
PD JUN
PY 2024
VL 82
AR 103041
DI 10.1016/j.ctim.2024.103041
EA APR 2024
PG 7
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA C5I6S
UT WOS:001289703800001
PM 38648942
OA gold
DA 2025-06-11
ER

PT J
AU Matvienko-Sikar, K
   O' Neill, K
   Fraser, A
   Hayes, C
   Howe, L
   Huizink, AC
   Kearney, PM
   Khashan, A
   Redsell, SA
   O'Keeffe, LM
AF Matvienko-Sikar, Karen
   O' Neill, Kate
   Fraser, Abigail
   Hayes, Catherine
   Howe, Laura
   Huizink, Anja C.
   Kearney, Patricia M.
   Khashan, Ali
   Redsell, Sarah A.
   O'Keeffe, Linda M.
TI Maternal prenatal anxiety and depression and trajectories of
   cardiometabolic risk factors across childhood and adolescence: a
   prospective cohort study
SO BMJ OPEN
LA English
DT Article
DE anxiety disorders; depression & mood disorders; cardiac epidemiology;
   prenatal diagnosis; epidemiology
ID BIRTH-WEIGHT; PREGNANCY; STRESS; HEALTH; METAANALYSIS; ASSOCIATION;
   EXPOSURE; CHILDREN; PARENTS; OBESITY
AB Objectives Quantifying long-term offspring cardiometabolic health risks associated with maternal prenatal anxiety and depression can guide cardiometabolic risk prevention. This study examines associations between maternal prenatal anxiety and depression, and offspring cardiometabolic risk from birth to 18 years. Design This study uses data from the Avon Longitudinal Study of Parents and Children (ALSPAC) cohort. Participants Participants were 526-8606 mother-offspring pairs from the ALSPAC cohort. Setting British birth cohort set, Bristol, UK. Primary and secondary outcomes Exposures were anxiety (Crown-Crisp Inventory score) and depression (Edinburgh Postnatal Depression Scale score) measured at 18 and 32 weeks gestation. Outcomes were trajectories of offspring body mass index; fat mass; lean mass; pulse rate; glucose, diastolic and systolic blood pressure (SBP); triglycerides, high-density lipoprotein cholesterol and non-high-density lipoprotein cholesterol and insulin from birth/early childhood to 18 years. Exposures were analysed categorically using clinically relevant, cut-offs and continuously to examine associations across the distribution of prenatal anxiety and depression. Results We found no strong evidence of associations between maternal anxiety and depression and offspring trajectories of cardiometabolic risk factors. Depression at 18 weeks was associated with higher SBP at age 18 (1.62 mm Hg (95% CI 0.17 to 3.07). Anxiety at 18 weeks was also associated with higher diastolic blood pressure at 7 years in unadjusted analyses (0.70 mm Hg (95% CI 0.02 to 1.38)); this difference persisted at age 18 years (difference at 18 years; 0.89 mm Hg (95% CI 0.05 to 1.73). No associations were observed for body mass index; fat mass; lean mass; pulse rate; glucose; triglycerides, high-density lipoprotein cholesterol and non-high-density lipoprotein cholesterol and insulin. Conclusions This is the first examination of maternal prenatal anxiety and depression and trajectories of offspring cardiometabolic risk. Our findings suggest that prevention of maternal prenatal anxiety and depression may have limited impact on offspring cardiometabolic health across the first two decades of life.
C1 [Matvienko-Sikar, Karen; O' Neill, Kate; Kearney, Patricia M.; Khashan, Ali; O'Keeffe, Linda M.] Univ Coll Cork, Sch Publ Hlth, Cork, Ireland.
   [Fraser, Abigail; Howe, Laura; O'Keeffe, Linda M.] Univ Bristol, Bristol Med Sch, Populat Hlth Sci, Bristol, Avon, England.
   [Hayes, Catherine] Trinity Coll Dublin, Sch Med, Dublin, Ireland.
   [Huizink, Anja C.] Vrije Univ Amsterdam, Dept Clin Neuro & Dev Psychol, Amsterdam, Netherlands.
   [Khashan, Ali] Cork Univ, Matern Hosp, Irish Ctr Maternal & Child Hlth Res INFANT Ctr, Cork, Ireland.
   [Redsell, Sarah A.] Univ Nottingham, Sch Hlth Sci, Nottingham, England.
   [O'Keeffe, Linda M.] Univ Bristol, MRC Integrat Epidemiol Unit, Bristol, Avon, England.
C3 University College Cork; University of Bristol; Trinity College Dublin;
   Vrije Universiteit Amsterdam; University College Cork; University of
   Nottingham; University of Bristol
RP Matvienko-Sikar, K (corresponding author), Univ Coll Cork, Sch Publ Hlth, Cork, Ireland.
EM karen.msikar@ucc.ie
RI Kearney, Patricia/AAE-8501-2020; Hayes, Catherine/D-3864-2016; Redsell,
   Sarah/A-6451-2009
OI Matvienko-Sikar, Karen/0000-0003-2777-6581; Hayes,
   Catherine/0000-0002-1576-4623; Fraser, Abigail/0000-0002-7741-9470;
   Huizink, Anja/0000-0003-2015-4819; Kearney, Patricia
   Maryclare/0000-0001-9599-3540; Redsell, Sarah/0000-0002-2176-2325;
   O'Keeffe, Linda/0000-0002-0003-0774
FU UK Medical Research Council [217065/Z/19/Z, MR/M020894/1, MR/M009351/1,
   MC_UU_00011/3, MC_UU_00011/6]; Wellcome [217065/Z/19/Z]; Health Research
   Board of Ireland (HRB) Applying Research into Policy and Practice award
   [HRB-ARPP-A011]; HRB Emerging Investigator Award [EIA-2019-007]; HRB
   Research Leader Award [HRB RL/2013/7]; HRB Interdisciplinary Capacity
   Enhancement Award [HRB ICE 2015-1026]; MRC [MC_UU_00011/3, MR/M020894/1,
   MC_UU_00011/6, MR/M009351/1] Funding Source: UKRI
FX The UK Medical Research Council and Wellcome (Grant ref: 217065/Z/19/Z)
   and the University of Bristol provide core support for ALSPAC. This
   publication is the work of the authors and KMS and LMOK will serve as
   guarantors for the contents of this paper. KMS is supported by a Health
   Research Board of Ireland (HRB) Applying Research into Policy and
   Practice award (HRB-ARPP-A011). LMOK and KON are supported by a HRB
   Emerging Investigator Award (EIA--2019--007). KON is also supported by a
   HRB Research Leader Award (HRB RL/2013/7) and a HRB Interdisciplinary
   Capacity Enhancement Award (HRB ICE 2015--1026). LDH and AF are
   supported by Career Development Awards from the UK Medical Research
   Council (grants MR/M020894/1 and MR/M009351/1, respectively). LDH and AF
   work in a unit that receives funds from the UK Medical Research Council
   (grant MC_UU_00011/3, MC_UU_00011/6). The research funders had no role
   in the study design; data collection, analysis, and interpretation of
   data; writing of the manuscript; or the decision to submit the
   manuscript for publication.
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NR 35
TC 1
Z9 1
U1 2
U2 8
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2044-6055
J9 BMJ OPEN
JI BMJ Open
PD DEC
PY 2021
VL 11
IS 12
AR e051681
DI 10.1136/bmjopen-2021-051681
PG 9
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA XP8HR
UT WOS:000731101300004
PM 34911713
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Bloomgarden, ZT
AF Bloomgarden, Zachary T.
TI American College of Endocrinology Pre-Diabetes Consensus Conference:
   Part Three
SO DIABETES CARE
LA English
DT Article
ID MUSCLE GLYCOGEN-SYNTHESIS; GENOME-WIDE ASSOCIATION; CARDIOVASCULAR
   RISK-FACTORS; INSULIN-RESISTANCE SYNDROME; CORONARY-HEART-DISEASE; FREE
   FATTY-ACIDS; GLUCOSE-TOLERANCE; METABOLIC SYNDROME; HEPATIC STEATOSIS;
   OXIDATIVE STRESS
C1 Mt Sinai Sch Med, Div Endocrinol, New York, NY USA.
C3 Icahn School of Medicine at Mount Sinai
RP Bloomgarden, ZT (corresponding author), Mt Sinai Sch Med, Div Endocrinol, New York, NY USA.
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NR 58
TC 9
Z9 10
U1 0
U2 0
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0149-5992
EI 1935-5548
J9 DIABETES CARE
JI Diabetes Care
PD DEC
PY 2008
VL 31
IS 12
BP 2404
EP 2409
DI 10.2337/dc08-zb12
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 381RB
UT WOS:000261552500034
PM 19033421
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Zelazniewicz, A
   Nowak-Kornicka, J
   Pawlowski, B
AF Zelazniewicz, Agnieszka
   Nowak-Kornicka, Judyta
   Pawlowski, Boguslaw
TI S-Klotho level and physiological markers of cardiometabolic risk in
   healthy adult men
SO AGING-US
LA English
DT Article
DE aging; healthspan; longevity; early marker; cardiometabolic risk
ID CARDIOVASCULAR RISK; METABOLIC SYNDROME; LEVELS CONTRIBUTE; SOLUBLE
   KLOTHO; PLASMA KLOTHO; TESTOSTERONE; GENE; ASSOCIATION; AGE; DISEASE
AB S-Klotho is perceived as a biomarker of healthy aging that has been shown to be inversely associated with cardiometabolic risk in elderly individuals. The aim of this study was to test if s-Klotho level is associated with cardiometabolic risk markers in younger healthy men in order to verify the possible role of s-Klotho level as an early marker of cardiometabolic risk. A cross-sectional study was conducted among 186 healthy men (M-age=35.33, SDage=3.47) from a Western urban population. Serum basal levels of s-Klotho, lipid profile, homocysteine, glycemia markers, C-reactive protein, liver transaminases and creatinine were evaluated. Also, blood pressure was measured and cardiometabolic risk score and homeostatic model assessment for insulin resistance (HOMA-IR) were calculated. Testosterone and cortisol levels, self-reported psychological stress, physical activity, smoking in the past, alcohol use and body adiposity were controlled for. We found no relationship between levels of s-Klotho and physiological markers of cardiometabolic risk in the studied population. The results were similar when controlled for adiposity, testosterone level, physical activity, alcohol use and smoking in the past. We suggest that s-Klotho level is not an early marker of cardiometabolic risk in younger middle-aged healthy men.
C1 [Zelazniewicz, Agnieszka; Nowak-Kornicka, Judyta; Pawlowski, Boguslaw] Univ Wroclaw, Dept Human Biol, Wroclaw, Poland.
C3 University of Wroclaw
RP Zelazniewicz, A (corresponding author), Univ Wroclaw, Dept Human Biol, Wroclaw, Poland.
EM agnieszka.zelazniewicz@uwr.edu.pl
RI Pawlowski, Boguslaw/C-1088-2013; Zelazniewicz, Agnieszka/X-9637-2018
OI Zelazniewicz, Agnieszka/0000-0002-8081-4922; Pawlowski,
   Boguslaw/0000-0002-7418-475X; Nowak-Kornicka, Judyta/0000-0002-3468-8128
FU Narodowe Centrum Nauki [2017/27/B/NZ8/00500]
FX Narodowe Centrum Nauki, grant no 2017/27/B/NZ8/00500.
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NR 74
TC 11
Z9 11
U1 1
U2 6
PU IMPACT JOURNALS LLC
PI ORCHARD PARK
PA 6666 E QUAKER ST, STE 1, ORCHARD PARK, NY 14127 USA
SN 1945-4589
J9 AGING-US
JI Aging-US
PD JAN 31
PY 2022
VL 14
IS 2
BP 708
EP 727
PG 20
WC Cell Biology; Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Geriatrics & Gerontology
GA ZO1SL
UT WOS:000765512300005
PM 35093938
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Wiggins, ER
   Brisson, JM
   Lavner, JA
   Ehrlich, KB
AF Wiggins, Elizabeth R.
   Brisson, Julie M.
   Lavner, Justin A.
   Ehrlich, Katherine B.
TI The benefits of nurturant-involved parenting for children's
   internalizing symptoms and cardiometabolic health in high-risk contexts
SO DEVELOPMENT AND PSYCHOPATHOLOGY
LA English
DT Article
DE cardiometabolic health; discrimination; internalizing symptoms;
   parenting; stress
ID AFRICAN-AMERICAN; PERCEIVED DISCRIMINATION; RACIAL-DISCRIMINATION;
   METABOLIC SYNDROME; ADOLESCENTS; STRESS; CHILDHOOD; FAMILY; WARMTH; PEER
AB Despite evidence that nurturant-involved parenting is linked with children's social, psychological, and physiological development, less is known about the specific contexts in which nurturant-involved parenting is most beneficial for children's mental and physical health. The present study examined how associations between nurturant-involved parenting and children's internalizing symptoms and cardiometabolic risk varied as a function of children's stress and discrimination. Participants included 165 Black and Latinx children (M-age = 11.5 years) and their guardians. Children reported on their ongoing stress, experiences of discrimination, and internalizing symptoms (depression and anxiety). Guardians provided information about their nurturant-involved parenting practices. Children's cardiometabolic risk was assessed as a composite reflecting a high level of systolic or diastolic blood pressure, waist circumference, HbA1c, triglycerides, and low HDL cholesterol. Regression analyses indicated that among youth who reported high levels of stress and discrimination, nurturant-involved parenting was negatively associated with cardiometabolic risk. Although children's stress and discrimination were significantly associated with their internalizing symptoms, neither stress nor discrimination moderated the relation between nurturant-involved parenting and internalizing symptoms. Results highlight the significant role that parents play in shaping children's health, particularly among youth experiencing high levels of stress and discrimination.
C1 [Wiggins, Elizabeth R.; Brisson, Julie M.; Lavner, Justin A.; Ehrlich, Katherine B.] Univ Georgia, Dept Psychol, Athens, GA 30602 USA.
   [Ehrlich, Katherine B.] Univ Georgia, Ctr Family Res, Athens, GA 30602 USA.
C3 University System of Georgia; University of Georgia; University System
   of Georgia; University of Georgia
RP Ehrlich, KB (corresponding author), Univ Georgia, Dept Psychol, Athens, GA 30602 USA.; Ehrlich, KB (corresponding author), Univ Georgia, Ctr Family Res, Athens, GA 30602 USA.
EM kehrlich@uga.edu
RI Wiggins, Elizabeth/KXR-0482-2024; Brisson, Julie/AAD-7904-2022
OI Wiggins, Elizabeth/0000-0001-7289-1656; Brisson,
   Julie/0000-0002-4747-9747; Ehrlich, Katherine/0000-0002-8958-6161
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NR 74
TC 1
Z9 1
U1 0
U2 5
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0954-5794
EI 1469-2198
J9 DEV PSYCHOPATHOL
JI Dev. Psychopathol.
PD DEC
PY 2023
VL 35
IS 5
SI SI
BP 2420
EP 2429
AR PII S0954579423000652
DI 10.1017/S0954579423000652
EA JUN 2023
PG 10
WC Psychology, Developmental
WE Social Science Citation Index (SSCI)
SC Psychology
GA HD4Q5
UT WOS:001016760900001
PM 37386849
OA Green Accepted, hybrid
DA 2025-06-11
ER

PT J
AU Greenman, Y
   Stern, N
AF Greenman, Yona
   Stern, Naftali
TI Obesity and depression
SO OBESITY AND METABOLISM-MILAN
LA English
DT Review
DE depression; metabolic syndrome; obesity; stress
ID INCREASED INTRAABDOMINAL FAT; METABOLIC SYNDROME; RISK-FACTORS;
   PSYCHIATRIC-DISORDERS; MENTAL-HEALTH; WEIGHT-LOSS; ASSOCIATION; LEPTIN;
   SYMPTOMS; PATHOPHYSIOLOGY
AB In this paper we provide a general overview of epidemiological, behavioral, psychosocial, biologic and pathophysiologic factors interconnecting obesity and depression. Given their increasing prevalence and associated major public health burden, continuing efforts to expand our understanding of these two disorders should be encouraged, as to allow for the development of more efficient ways of prevention and treatment.
C1 [Greenman, Yona] Tel Aviv Sourasky Med Ctr, Inst Endocrinol Metab & Hypertens, IL-64239 Tel Aviv, Israel.
   Tel Aviv Univ, Sackler Sch Med, IL-69978 Tel Aviv, Israel.
C3 Tel Aviv University; Sackler Faculty of Medicine; Tel Aviv Sourasky
   Medical Center; Tel Aviv University; Sackler Faculty of Medicine
RP Greenman, Y (corresponding author), Tel Aviv Sourasky Med Ctr, Inst Endocrinol Metab & Hypertens, 6 Weizman St, IL-64239 Tel Aviv, Israel.
EM greenman@tasmc.health.gov.il
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NR 53
TC 0
Z9 1
U1 0
U2 12
PU EDITRICE KURTIS S R L
PI MILAN
PA VIA LUIGI ZOJA 30, 20153 MILAN, ITALY
SN 1825-3865
EI 1826-7572
J9 OBES METAB-MILAN
JI Obes. Metab.-Milan
PD DEC
PY 2007
VL 3
IS 4
BP 206
EP 213
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 339HM
UT WOS:000258568700007
DA 2025-06-11
ER

PT J
AU Mofrad, MD
   Siassi, F
   Guilani, B
   Bellissimo, N
   Azadbakht, L
AF Mofrad, Manije Darooghegi
   Siassi, Fereydoun
   Guilani, Bijan
   Bellissimo, Nick
   Azadbakht, Leila
TI Association of dietary phytochemical index and mental health in women: a
   cross-sectional study
SO BRITISH JOURNAL OF NUTRITION
LA English
DT Article
DE Dietary phytochemical index; Diet quality; Depressive symptoms; Anxiety;
   Psychological distress
ID CORONARY-HEART-DISEASE; 3-YEAR FOLLOW-UP; METABOLIC SYNDROME; DEPRESSIVE
   SYMPTOMS; MEDITERRANEAN DIET; OXIDATIVE STRESS; ADULT-POPULATION; RISK;
   ANXIETY; CONSUMPTION
AB Previous studies have shown that unhealthy dietary patterns are among the most important modifiable risk factors in the development of mental health disorders. We examined the association of dietary phytochemical index (DPI) with symptoms of depression, anxiety and psychological distress in Iranian women. In this cross-sectional study, a total of 488 women aged 20-50 years old attending health centres in the south of Tehran in 2018 were included. A validated and reliable FFQ was used for dietary assessment. Symptoms of depression, anxiety and psychological distress were assessed using a validated depression, anxiety, stress scales questionnaires with twenty-one-items. DPI was estimated using the following formula: (daily energy derived from phytochemical-rich foods (kJ)/total daily energy intake (kJ))x100. The mean age of the study participants was 319 (sd 77) years. The prevalence of depressive symptoms, anxiety and psychological distress among study participants was 346, 406 and 424 %, respectively. After controlling for potential confounders, women in the highest tertile of DPI had a lower prevalence of depressive symptoms (OR 022; 95 % CI 012, 038) and anxiety (OR 033; 95 % CI 020, 055), as well as psychological distress (OR 030; 95 % CI 018, 049) compared with those in the lowest tertile. In conclusion, we found a significant association between DPI and mental health in women. Prospective studies are needed to confirm these findings.
C1 [Mofrad, Manije Darooghegi; Siassi, Fereydoun; Azadbakht, Leila] Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Community Nutr, POB 1416643931, Tehran, Iran.
   [Mofrad, Manije Darooghegi] Univ Tehran Med Sci, Students Sci Res Ctr, POB 1417755331, Tehran, Iran.
   [Guilani, Bijan] Univ Tehran, Dept Clin Psychol, Tehran, Iran.
   [Bellissimo, Nick] Ryerson Univ, Sch Nutr, Toronto, ON M5B 2K3, Canada.
   [Azadbakht, Leila] Univ Tehran Med Sci, Diabet Res Ctr, Endocrinol & Metab Clin Sci Inst, POB 14155-611Z, Tehran, Iran.
   [Azadbakht, Leila] Isfahan Univ Med Sci, Sch Nutr & Food Sci, Dept Community Nutr, POB 81745-151, Esfahan, Iran.
C3 Tehran University of Medical Sciences; Tehran University of Medical
   Sciences; University of Tehran; Toronto Metropolitan University; Tehran
   University of Medical Sciences; Isfahan University of Medical Sciences
RP Azadbakht, L (corresponding author), Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Community Nutr, POB 1416643931, Tehran, Iran.; Azadbakht, L (corresponding author), Univ Tehran Med Sci, Diabet Res Ctr, Endocrinol & Metab Clin Sci Inst, POB 14155-611Z, Tehran, Iran.; Azadbakht, L (corresponding author), Isfahan Univ Med Sci, Sch Nutr & Food Sci, Dept Community Nutr, POB 81745-151, Esfahan, Iran.
EM azadbakhtleila@gmail.com
RI Azadbakht, Leila/N-2801-2018
OI Bellissimo, Nick/0000-0002-6177-3731
FU TUMS
FX The study was financially supported by TUMS.
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NR 63
TC 34
Z9 34
U1 0
U2 11
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1145
EI 1475-2662
J9 BRIT J NUTR
JI Br. J. Nutr.
PD MAY 14
PY 2019
VL 121
IS 9
BP 1049
EP 1056
DI 10.1017/S0007114519000229
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nutrition & Dietetics
GA ID5WK
UT WOS:000471747800009
PM 30714542
OA Bronze
DA 2025-06-11
ER

PT J
AU Amerikanou, C
   Valsamidou, E
   Kleftaki, SA
   Gioxari, A
   Koutoulogenis, K
   Aroutiounova, M
   Stergiou, I
   Kaliora, AC
AF Amerikanou, Charalampia
   Valsamidou, Evdokia
   Kleftaki, Stamatia-Angeliki
   Gioxari, Aristea
   Koutoulogenis, Konstantinos
   Aroutiounova, Maria
   Stergiou, Ioannis
   Kaliora, Andriana C.
TI Peripheral inflammation is linked with emotion and mental health in
   people with obesity. A "head to toe" observational study
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Article
DE obesity; metabolic syndrome; inflammation; oxidative stress; mental
   health
ID METABOLIC SYNDROME; PHYSICAL-ACTIVITY; OXIDATIVE STRESS; SELF-ESTEEM;
   DEPRESSION; DIET; SCALE
AB BackgroundObesity is a significant worldwide health problem that is linked with mental health. The elucidation of the possible overlapping biochemical mechanism(s) involved in inflammation and oxidative stress is imperative to better understand and address obesity and related metabolic disorders. The aim of the study was to investigate the associations between inflammatory and oxidative stress profiles with parameters that reflect metabolic, emotional, and mental health in a Greek metabolically unhealthy obese cohort. MethodsIn total, 122 metabolically unhealthy people with obesity were recruited. Anthropometric measurements, biochemical, inflammatory and oxidative stress markers were assessed. Quality of life was evaluated through questionnaires for insomnia, self-esteem, depression, physical and mental health. ResultsThe inflammatory biomarker tumor necrosis factor-alpha (TNF-& alpha;) and the ratio oxidized low-density lipoprotein/low-density lipoprotein (oxLDL/LDL) were higher in hypertensive (p=0.002, p=0.001 respectively) and hyperglycemic subjects (p=0.017, p=0.001 respectively). Furthermore TNF-& alpha; (p<0.001), oxLDL/LDL (p<0.001) and oxLDL/high-density lipoprotein (HDL) (p=0.016) increased significantly with the increase of metabolic syndrome components. Finally, a negative association between interleukin-6 (IL-6) and Rosenberg Self-Esteem Scale (Beta=-0.019, p=0.019) and a positive association between TNF-& alpha; and the Center for Epidemiologic Studies Depression Scale Revised (Beta=0.003, p=0.015) were found. ConclusionsThe results of the study suggest that obesity-related systemic inflammation is associated with worse self-esteem and depression symptoms, indicating an overlapping mechanism which can be utilized to the management of obesity.
C1 [Amerikanou, Charalampia; Valsamidou, Evdokia; Kleftaki, Stamatia-Angeliki; Gioxari, Aristea; Koutoulogenis, Konstantinos; Kaliora, Andriana C.] Harokopio Univ, Sch Hlth Sci & Educ, Dept Nutr & Dietet, Athens, Greece.
   [Gioxari, Aristea] Univ Peloponnese, Sch Hlth Sci, Dept Nutr Sci & Dietet, Kalamata, Greece.
   [Aroutiounova, Maria; Stergiou, Ioannis] Gen Hosp G Gennimatas, Diabet Outpatient Dept, Thessaloniki, Greece.
C3 Harokopio University Athens; University of Peloponnese
RP Kaliora, AC (corresponding author), Harokopio Univ, Sch Hlth Sci & Educ, Dept Nutr & Dietet, Athens, Greece.
EM akaliora@hua.gr
RI Gioxari, Aristea/AAA-1163-2021; Amerikanou, Charalampia/ABE-1634-2022;
   Kaliora, Andriana/AAM-2912-2021
OI AMERIKANOU, CHARALAMPIA/0000-0002-2014-5392; Kleftaki,
   Matina/0000-0003-2741-2761; Gioxari, Aristea/0000-0002-4869-6815;
   Valsamidou, Evdokia/0000-0002-1275-3494
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NR 50
TC 1
Z9 1
U1 0
U2 1
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD JUL 14
PY 2023
VL 14
AR 1197648
DI 10.3389/fendo.2023.1197648
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA N5WB1
UT WOS:001037701200001
PM 37529617
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Daneshzad, E
   Keshavarz, SA
   Qorbani, M
   Larijani, B
   Bellissimo, N
   Azadbakht, L
AF Daneshzad, Elnaz
   Keshavarz, Seyed-Ali
   Qorbani, Mostafa
   Larijani, Bagher
   Bellissimo, Nick
   Azadbakht, Leila
TI Association of dietary acid load and plant-based diet index with sleep,
   stress, anxiety and depression in diabetic women
SO BRITISH JOURNAL OF NUTRITION
LA English
DT Article
DE Dietary acid load; Plant-based diet index; Sleep; Depression; Diabetic
   patients; Women
ID METABOLIC SYNDROME; MENTAL-HEALTH; QUALITY; ADULTS; PREVALENCE;
   PATTERNS; GLUCOCORTICOIDS; INFLAMMATION; METAANALYSIS; POPULATION
AB Diabetes is a common chronic disease with various complications. The present study was conducted to determine the association of plant-based diet index (PDI) and dietary acid load (DAL) with sleep status as well as mental health in type 2 diabetic women. In this cross-sectional study, a validated FFQ was used to assess dietary intakes of 230 diabetic patients. We created a whole PDI, healthful PDI (hPDI) and unhealthful PDI (uPDI). DAL was calculated based on potential renal acid load and net endogenous acid production method. The Pittsburgh Sleep Quality Index and twenty-one-item Depression, Anxiety and Stress Scale were used to assess sleep and mental health disorders, respectively. Participants in the top group of uPDI had greater risk of poor sleep (OR 6 center dot 47, 95 % CI 2 center dot 75, 15 center dot 24). However, patients who were in the top group of hPDI had a lower risk of sleep problems (OR 0 center dot 28, 95 % CI 0 center dot 13, 0 center dot 62). Participants in the top group of uPDI had greater risk of depression, anxiety and stress (OR 9 center dot 35, 95 % CI 3 center dot 96, 22 center dot 07; OR 4 center dot 74, 95 % CI 2 center dot 28, 9 center dot 85; OR 4 center dot 24, 95 % CI 2 center dot 14, 8 center dot 38, respectively). In conclusion, participants with higher DAL scores and patients who adhered to animal-based diets rather than plant-based diets were more likely to be poor sleepers and have mental health disorders.
C1 [Daneshzad, Elnaz; Azadbakht, Leila] Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Community Nutr, Tehran, Iran.
   [Keshavarz, Seyed-Ali] Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Clin Nutr, Tehran, Iran.
   [Qorbani, Mostafa] Alborz Univ Med Sci, Noncommunicable Dis Res Ctr, Karaj, Iran.
   [Qorbani, Mostafa] Univ Tehran Med Sci, Chron Dis Res Ctr, Endocrinol & Metab Populat Sci Inst, Tehran, Iran.
   [Larijani, Bagher] Univ Tehran Med Sci, Endocrinol & Metab Res Ctr, Endocrinol & Metab Clin Sci Inst, Tehran, Iran.
   [Bellissimo, Nick] Ryerson Univ, Sch Nutr, Toronto, ON, Canada.
   [Azadbakht, Leila] Univ Tehran Med Sci, Endocrinol & Metab Clin Sci Inst, Diabet Res Ctr, Tehran, Iran.
C3 Tehran University of Medical Sciences; Tehran University of Medical
   Sciences; Alborz University of Medical Sciences; Tehran University of
   Medical Sciences; Tehran University of Medical Sciences; Toronto
   Metropolitan University; Tehran University of Medical Sciences
RP Azadbakht, L (corresponding author), Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Community Nutr, Tehran, Iran.; Azadbakht, L (corresponding author), Univ Tehran Med Sci, Endocrinol & Metab Clin Sci Inst, Diabet Res Ctr, Tehran, Iran.
EM azadbakhtleila@gmail.com
RI Azadbakht, Leila/N-2801-2018; larijani, Bagher/ABE-3315-2020; Qorbani,
   Mostafa/M-8171-2017; keshavarz, Seyed/AAD-3261-2019; Daneshzad,
   Elnaz/O-3694-2018
OI Bellissimo, Nick/0000-0002-6177-3731; Daneshzad,
   Elnaz/0000-0003-1400-8532; Larijani, Bagher/0000-0001-5386-7597
FU Tehran University of Medical Sciences [96-03-161-36923]
FX The present study is supported by Tehran University of Medical Sciences
   (grant number 96-03-161-36923). We would like to express our gratitude
   to Dr Nasli, secretary of the Diabetes Research Center of Tehran
   University of Medical Sciences, and all staff member for their help with
   the present study. The present study was approved by the ethical
   committee of Tehran University of Medical Sciences.
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NR 60
TC 47
Z9 48
U1 1
U2 38
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1145
EI 1475-2662
J9 BRIT J NUTR
JI Br. J. Nutr.
PD APR 28
PY 2020
VL 123
IS 8
BP 901
EP 912
DI 10.1017/S0007114519003179
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nutrition & Dietetics
GA KR8AU
UT WOS:000517839100007
PM 31806069
DA 2025-06-11
ER

PT J
AU Teasdale, SB
   Latimer, G
   Byron, A
   Schuldt, V
   Pizzinga, J
   Plain, J
   Buttenshaw, K
   Forsyth, A
   Parker, E
   Soh, N
AF Teasdale, Scott B.
   Latimer, Geogina
   Byron, Annette
   Schuldt, Vanessa
   Pizzinga, Josephine
   Plain, Janice
   Buttenshaw, Kerryn
   Forsyth, Adrienne
   Parker, Elizabeth
   Soh, Nerissa
TI Expanding collaborative care: integrating the role of dietitians and
   nutrition interventions in services for people with mental illness
SO AUSTRALASIAN PSYCHIATRY
LA English
DT Article
DE diet; nutrition; mental illness; mental disorder; intervention
ID ANTIPSYCHOTIC MEDICATIONS; CARDIOMETABOLIC RISK; EATING-BEHAVIOR;
   DEPRESSION; SCHIZOPHRENIA; METAANALYSIS; ADULTS
AB Objective: This article aims to draw mental health clinicians' attention to the connections between nutrition and mental health, and the roles that Accredited Practising Dietitians play in improving mental and physical health through dietary change.
   Methods: Selective narrative review.
   Results: Unhealthy dietary practices are common in high prevalence and severe mental illness. Epidemiological evidence demonstrates that nutrients and dietary patterns impact on mental health. In addition, poor physical health is well documented in people with mental illness and the greatest contributor to the mortality gap. Dietary intervention studies demonstrate improved mental and physical health outcomes. Accredited Practising Dietitians translate nutrition science into practical advice to improve the nutritional status of patients with mental illness, and prevent and manage comorbidities in a variety of care settings.
   Conclusions: Medical Nutrition Therapy offers opportunities to improve the physical and mental health of people living with mental illness.
C1 [Teasdale, Scott B.] South Eastern Sydney Local Hlth Dist, Keeping Body Mind Program, Sydney, NSW, Australia.
   [Teasdale, Scott B.] Univ New South Wales, Sch Psychiat, Sydney, NSW, Australia.
   [Latimer, Geogina] Cohealth, Melbourne, Vic, Australia.
   [Byron, Annette; Schuldt, Vanessa] Dietitians Assoc Australia, Deakin, ACT, Australia.
   [Pizzinga, Josephine] IPC Hlth, Melbourne, Vic, Australia.
   [Plain, Janice] Macquarie Hosp, Patient Serv, Sydney, NSW, Australia.
   [Buttenshaw, Kerryn] Queensland Univ Technol, Fac Hlth, Brisbane, Qld, Australia.
   [Forsyth, Adrienne] La Trobe Univ, Sch Allied Hlth, Melbourne, Vic, Australia.
   [Parker, Elizabeth] Westmead Hosp, Dept Nutr & Dietet, Sydney, NSW, Australia.
   [Soh, Nerissa] Univ Sydney, Northern Clin Sch, Psychiat, Sydney, NSW, Australia.
C3 South Eastern Sydney Local Health District; University of New South
   Wales Sydney; Queensland University of Technology (QUT); La Trobe
   University; NSW Health; Westmead Hospital; University of Sydney;
   University of Sydney
RP Teasdale, SB (corresponding author), South Eastern Sydney Local Hlth Dist, Keeping Body Mind Program, 26 Llandaff St, Bondi Jct, NSW 2022, Australia.
EM Scott.Teasdale@sesiahs.health.nsw.gov.au
RI Teasdale, Scott/AFP-0676-2022; Forsyth, Adrienne/ISB-2103-2023
OI Forsyth, Adrienne/0000-0002-1692-2638; Teasdale,
   Scott/0000-0001-6769-8421
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NR 22
TC 25
Z9 26
U1 0
U2 25
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1039-8562
EI 1440-1665
J9 AUSTRALAS PSYCHIATRY
JI Australas. Psychiatry
PD FEB
PY 2018
VL 26
IS 1
BP 47
EP 49
DI 10.1177/1039856217726690
PG 3
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA FU4AP
UT WOS:000423795500011
PM 28869391
DA 2025-06-11
ER

PT J
AU Allen, B
   Jennings, JR
   Muldoon, MF
   Gianaros, PJ
AF Allen, Ben
   Jennings, John Richard
   Muldoon, Matthew F.
   Gianaros, Peter J.
TI Frontostriatal Brain Activation Is Associated With the Longitudinal
   Progression of Cardiometabolic Risk
SO PSYCHOSOMATIC MEDICINE
LA English
DT Article
DE cardiometabolic risk; brain; cerebral blood flow
ID AUTONOMIC NERVOUS-SYSTEM; BLOOD-PRESSURE; METABOLIC SYNDROME;
   CARDIOVASCULAR-DISEASE; PSYCHOLOGICAL STRESS; FOLLOW-UP; PREDICTS; FLOW;
   REACTIVITY; VOLUME
AB Objective: Cardiometabolic risk refers to a set of interconnected factors of vascular and metabolic origin associated with both cardiovascular disease and various brain disorders. Although midlife cardiometabolic risk is associated with future brain dysfunction, emerging evidence suggests that alterations in autonomic and central nervous system function may precede increases in cardiometabolic risk.
   Methods: The present study tested whether patterns of cerebral blood flow in brain areas associated with autonomic regulation were associated with increases in overall cardiometabolic risk. A community sample of 109 adults with resting systolic blood pressure between 120 and 139 mm Hg, diastolic blood pressure between 80 and 89 mm Hg, or both underwent pseudocontinuous arterial spin labeling to quantify cerebral blood flow responses to cognitively challenging tasks. Cardiometabolic risk and cerebral blood flow measurements were collected at baseline and at a 2-year follow-up.
   Results: Regression analyses showed that greater frontostriatal cerebral blood flow responses to cognitive challenge were associated with higher cardiometabolic risk at follow-up (beta = 0.26 [95% confidence interval = 0.07 to 0.44],t = 2.81, p = .006, Delta R-2 = 0.04). These findings were specific to frontostriatal brain regions, as frontoparietal, insular-subcortical, and total cerebral blood flow were not associated with progression of cardiometabolic risk. Moreover, cardiometabolic risk was not associated with frontostriatal cerebral blood flow responses 2 years later.
   Conclusions: Frontostriatal brain function may precede and possibly forecast the progression of cardiometabolic risk.
C1 [Allen, Ben] Univ Tennessee, Dept Psychol, Knoxville, TN 37996 USA.
   [Jennings, John Richard] Univ Pittsburgh, Dept Psychiat & Psychol, Pittsburgh, PA 15260 USA.
   [Muldoon, Matthew F.] Univ Pittsburgh, Sch Med, Inst Heart & Vasc, Pittsburgh, PA 15260 USA.
   [Gianaros, Peter J.] Univ Pittsburgh, Dept Psychol, Pittsburgh, PA 15260 USA.
C3 University of Tennessee System; University of Tennessee Knoxville;
   Pennsylvania Commonwealth System of Higher Education (PCSHE); University
   of Pittsburgh; Pennsylvania Commonwealth System of Higher Education
   (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of
   Higher Education (PCSHE); University of Pittsburgh
RP Allen, B (corresponding author), Austin Peay1404 Circle Dr, Knoxville, TN 37916 USA.
EM ballen50@utk.edu
FU  [R01 HL089850];  [R01 HL101959];  [T32 HL007560]
FX This work was supported by grants R01 HL089850, R01 HL101959, and T32
   HL007560. None declared.
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NR 53
TC 1
Z9 1
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0033-3174
EI 1534-7796
J9 PSYCHOSOM MED
JI Psychosom. Med.
PD JUN
PY 2020
VL 82
IS 5
BP 454
EP 460
DI 10.1097/PSY.0000000000000811
PG 7
WC Psychiatry; Psychology; Psychology, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry; Psychology
GA MM3PM
UT WOS:000550071900001
PM 32310839
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Haufe, S
   Kahl, KG
   Kerling, A
   Protte, G
   Bayerle, P
   Stenner, HT
   Rolff, S
   Sundermeier, T
   Eigendorf, J
   Kück, M
   Hanke, AA
   Keller-Varady, K
   Ensslen, R
   Nachbar, L
   Lauenstein, D
   Böthig, D
   Terkamp, C
   Stiesch, M
   Hilfiker-Kleiner, D
   Haverich, A
   Tegtbur, U
AF Haufe, Sven
   Kahl, Kai G.
   Kerling, Arno
   Protte, Gudrun
   Bayerle, Pauline
   Stenner, Hedwig T.
   Rolff, Simone
   Sundermeier, Thorben
   Eigendorf, Julian
   Kueck, Momme
   Hanke, Alexander A.
   Keller-Varady, Katriona
   Ensslen, Ralf
   Nachbar, Lars
   Lauenstein, Dirk
   Boethig, Dietmar
   Terkamp, Christoph
   Stiesch, Meike
   Hilfiker-Kleiner, Denise
   Haverich, Axel
   Tegtbur, Uwe
TI Employers With Metabolic Syndrome and Increased Depression/Anxiety
   Severity Profit Most From Structured Exercise Intervention for Work
   Ability and Quality of Life.
SO FRONTIERS IN PSYCHIATRY
LA English
DT Article
DE physical activity; telemonitoring; activity devices; productivity;
   mental health
ID MAJOR DEPRESSIVE DISORDER; PHYSICAL-ACTIVITY; PREVALENCE; PEOPLE;
   IMPACT; SYMPTOMS; BEHAVIOR; ANXIETY; BURDEN; HEALTH
AB Background Major depressive disorder and anxiety disorders are associated with less productivity, earlier retirement, and more sick-days at the workplace. These associations also exist for patients with metabolic syndrome. For both, exercise is a generally recommended part of multimodal treatments. However, for individuals with metabolic syndrome, in which depression and anxiety is more prevalent and severe, evidence for the efficacy of exercise interventions is limited. Methods Company employees with diagnosed metabolic syndrome (n=314, age: 48 +/- 8 yrs) were randomized to a 6-month exercise intervention (150 min per week) or wait-list control. Participants received individual recommendations for exercise activities by personal meetings, telephone, orviaa smartphone app. Physical activities were supervised and adapted using activity monitor data transferred to a central database. Work ability (work ability index), depression severity and anxiety severity [hospital anxiety and depression scale (HADS)], and health-related quality of live [short form 36 (SF-36)] were assessed. Results We included 314 subjects from which 287 finished the intervention. Total work ability, depression- and anxiety severity, and the mental component score of the SF-36 improved after 6 months exercise compared to controls. After baseline stratification for normal (HADS scores 0-7) and increased depression- and anxiety scores (HADS scores 8-21) individuals with increased severity scores had similar age, body composition, blood lipids, and cardiorespiratory fitness compared to those with normal scores, but lower total work ability and component sum scores of health-related quality of life. After 6 months total work ability increased in the exercise group compared to controls with the magnitude of the observed increase being significantly greater for subjects with increased depression- and anxiety severity at baseline compared to those with normal severity scores. Conclusions A 6-month exercise intervention for company employees with metabolic syndrome showed strongest effects on self-perceived work ability in individuals with mild to severe depression- and anxiety severity. This suggests exercise programs offered to workers with metabolic syndrome not only reduces individual disease risk but may also reduce healthcare and employers costs arising from metabolic syndrome and mental disease conditions.
C1 [Haufe, Sven; Kerling, Arno; Protte, Gudrun; Bayerle, Pauline; Stenner, Hedwig T.; Rolff, Simone; Sundermeier, Thorben; Eigendorf, Julian; Kueck, Momme; Hanke, Alexander A.; Keller-Varady, Katriona; Tegtbur, Uwe] Hannover Med Sch, Inst Sports Med, Hannover, Germany.
   [Kahl, Kai G.] Hannover Med Sch, Dept Psychiat Social Psychiat & Psychotherapy, Hannover, Germany.
   [Ensslen, Ralf; Nachbar, Lars] Volkswagen AG, Wolfsburg, Germany.
   [Lauenstein, Dirk] Audi BKK Hlth Insurance, Ingolstadt, Germany.
   [Boethig, Dietmar; Haverich, Axel] Hannover Med Sch, Dept Cardiac Thorac Transplantat & Vasc Surg, Hannover, Germany.
   [Terkamp, Christoph] Hannover Med Sch, Dept Gastroenterol Hepatol & Endocrinol, Hannover, Germany.
   [Stiesch, Meike] Hannover Med Sch, Dept Prosthet Dent & Biomed Mat Sci, Hannover, Germany.
   [Hilfiker-Kleiner, Denise] Hannover Med Sch, Dept Cardiol & Angiol, Hannover, Germany.
C3 Hannover Medical School; Hannover Medical School; Volkswagen; Volkswagen
   Germany; Hannover Medical School; Hannover Medical School; Hannover
   Medical School; Hannover Medical School
RP Haufe, S (corresponding author), Hannover Med Sch, Inst Sports Med, Hannover, Germany.
EM haufe.sven@mh-hannover.de
RI Haufe, Sven/G-1944-2011; Haverich, Axel/AAC-7552-2022; Stiesch,
   Meike/GRX-4992-2022
OI Haufe, Sven/0000-0002-5259-4352; Eigendorf, Julian/0000-0001-6429-3103;
   Boeck, Hedwig Theda/0000-0001-9588-4336
FU Audi BKK health insurance; German Research Foundation through the
   Cluster of Excellence "REBIRTH"
FX This study was supported and funded by grants from Audi BKK health
   insurance and the German Research Foundation through the Cluster of
   Excellence "REBIRTH". The funder Audi BKK health insurance was not
   involved in the study design, collection, analysis, interpretation of
   data, the writing of this article or the decision to submit it for
   publication.
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NR 46
TC 11
Z9 11
U1 1
U2 13
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-0640
J9 FRONT PSYCHIATRY
JI Front. Psychiatry
PD JUN 18
PY 2020
VL 11
AR 562
DI 10.3389/fpsyt.2020.00562
PG 11
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA MH5XY
UT WOS:000546802900001
PM 32625123
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Lee, IT
   Rees, J
   King, S
   Kim, A
   Cherlin, T
   Hinkle, S
   Mumford, SL
   Dokras, A
AF Lee, Iris T.
   Rees, John
   King, Shakira
   Kim, Anne
   Cherlin, Tess
   Hinkle, Stefanie
   Mumford, Sunni L.
   Dokras, Anuja
TI Depression, Anxiety, and Risk of Metabolic Syndrome in Women With
   Polycystic Ovary Syndrome: A Longitudinal Study
SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Article
DE metabolic syndrome; polycystic ovary syndrome; mental health; anxiety;
   depression
ID CARDIOVASCULAR-DISEASE; ASSOCIATION; METAANALYSIS; HEALTH; PCOS
AB Context Patients with polycystic ovary syndrome (PCOS) are at high risk of depression, anxiety, and metabolic syndrome (MetSyn), a key predictor of cardiovascular disease. The impact of depression and/or anxiety on MetSyn is unknown in this population.Objective To compare the risk of developing MetSyn in patients with PCOS with and without a history of depression and/or anxiety.Methods Retrospective longitudinal cohort study (2008-2022) with median follow-up of 7 years at a tertiary care ambulatory practice. Patients with hyperandrogenic PCOS and at least 2 evaluations for MetSyn >= 3 years apart (n = 321) were included. The primary outcome was risk of developing MetSyn. We hypothesized that this risk would be higher with a history of depression and/or anxiety.Results At the first visit, 33.0% had a history of depression and/or anxiety, with a third prescribed antidepressants or anxiolytics. Depression and/or anxiety increased risk of developing MetSyn during the study period (adjusted hazard ratio [aHR] 1.45, 95% CI 1.02-2.06, P = .04) with an incidence of MetSyn of 75.3 compared with 47.6 cases per 100 person-years among those without (P = .002). This was primarily driven by depression (aHR 1.56, 95% CI 1.10-2.20, P = .01).Conclusion Patients with PCOS and depression and/or anxiety have a high risk of developing MetSyn, with a stronger association between depression and MetSyn. Our findings highlight the urgent need for guideline-directed screening for depression and anxiety at time of diagnosis of PCOS as well as screening at subsequent visits to facilitate risk stratification for metabolic monitoring and early intervention in this high-risk group.
C1 [Lee, Iris T.; Kim, Anne; Hinkle, Stefanie; Mumford, Sunni L.; Dokras, Anuja] Univ Penn, Dept Obstet & Gynecol, 3701 Market St,8th Fl, Philadelphia, PA 19104 USA.
   [Rees, John; King, Shakira; Cherlin, Tess] Univ Penn, Perelman Sch Med, Philadelphia, PA 19104 USA.
   [Hinkle, Stefanie; Mumford, Sunni L.] Univ Penn, Dept Biostat Epidemiol & Informat, Philadelphia, PA 19104 USA.
C3 University of Pennsylvania; University of Pennsylvania; University of
   Pennsylvania
RP Lee, IT (corresponding author), Univ Penn, Dept Obstet & Gynecol, 3701 Market St,8th Fl, Philadelphia, PA 19104 USA.
EM leeir@pennmedicine.upenn.edu
RI Hinkle, Stefanie/ABI-8326-2020; Hinkle, Stefanie/F-8253-2013
OI Hinkle, Stefanie/0000-0003-4312-708X; Lee, Iris/0000-0002-4319-4429
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NR 30
TC 2
Z9 2
U1 6
U2 6
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0021-972X
EI 1945-7197
J9 J CLIN ENDOCR METAB
JI J. Clin. Endocrinol. Metab.
PD APR 30
PY 2024
VL 110
IS 3
BP e750
EP e756
DI 10.1210/clinem/dgae256
EA APR 2024
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA X2K5M
UT WOS:001209700700001
PM 38609160
DA 2025-06-11
ER

PT J
AU Nishimi, KM
   Koenen, KC
   Coull, BA
   Chen, RJ
   Kubzansky, LD
AF Nishimi, Kristen M.
   Koenen, Karestan C.
   Coull, Brent A.
   Chen, Ruijia
   Kubzansky, Laura D.
TI Psychological resilience predicting cardiometabolic conditions in
   adulthood in the Midlife in the United States Study
SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF
   AMERICA
LA English
DT Article
DE psychological resilience; cardiometabolic disease; early adversity;
   biomarkers
ID ADVERSE CHILDHOOD EXPERIENCES; STRESS RESILIENCE; SOCIAL DISADVANTAGE;
   MENTAL-HEALTH; RISK; DISEASE; IMPACT; PREVENTION; EXPOSURE; CONTEXT
AB Early adversity is associated with poor cardiometabolic health, potentially via psychological distress. However, not everyone exposed to adversity develops significant distress. Psychological resilience and positive psychological health despite adversity may protect against unfavorable cardiometabolic outcomes that are otherwise more likely. We examined early adversity, psychological resilience, and cardiometabolic risk among 3,254 adults in the Midlife in the United States Study. Psychological resilience was defined according to both early psychosocial adversity and adult psychological health (characterized by low distress and high wellbeing) at Wave 1 (1994 to 1995). Categorical resilience was derived by cross-classifying adversity (exposed versus unexposed) and psychological health (higher versus lower). We also assessed count of adversities experienced and psychological symptoms as separate variables. Incident cardiometabolic conditions (e.g., heart attack, stroke, and diabetes) were self-reported at Waves 2 (2004 to 2005) and 3 (2013 to 2014). Secondary analyses examined biological cardiometabolic risk using a composite of biomarkers available within a Wave-2 subsample. Logistic and Poisson regressions evaluated associations of resilience with cardiometabolic health across 20 follow-up y, adjusting for relevant covariates. In this initially healthy sample, nonresilient (adversity-exposed, lower psychological health) versus resilient (adversity-exposed, high psychological health) individuals had 43% higher odds of cardiometabolic conditions (95% CI 1.10 to 1.85). Odds of cardiometabolic conditions were similar among resilient versus unexposed, psychologically healthy individuals. More adversity experiences were associated with increased odds, while better psychological health with decreased odds of cardiometabolic conditions, and effects were largely independent. Patterns were similar for objectively assessed cardiometabolic risk. Psychological resilience in midlife may protect against negative cardiometabolic impacts of early adversity.
C1 [Nishimi, Kristen M.] Mental Hlth Serv, Serv San Francisco Vet Affairs Med Ctr, San Francisco, CA 94121 USA.
   [Nishimi, Kristen M.] Univ Calif San Francisco, Dept Psychiat, San Francisco, CA 94143 USA.
   [Nishimi, Kristen M.] Univ Calif San Francisco, Weill Inst Neurosci, San Francisco, CA 94143 USA.
   [Koenen, Karestan C.; Chen, Ruijia; Kubzansky, Laura D.] Harvard TH Chan Sch Publ Hlth, Dept Social & Behav Sci, Boston, MA 02115 USA.
   [Koenen, Karestan C.] Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.
   [Coull, Brent A.] Harvard TH Chan Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA.
C3 University of California System; University of California San Francisco;
   University of California System; University of California San Francisco;
   Harvard University; Harvard T.H. Chan School of Public Health; Harvard
   University; Harvard T.H. Chan School of Public Health; Harvard
   University; Harvard T.H. Chan School of Public Health
RP Nishimi, KM (corresponding author), Mental Hlth Serv, Serv San Francisco Vet Affairs Med Ctr, San Francisco, CA 94121 USA.; Nishimi, KM (corresponding author), Univ Calif San Francisco, Dept Psychiat, San Francisco, CA 94143 USA.
EM kristen.nishimi@ucsf.edu
RI Koenen, Karestan/K-5402-2014; Nishimi, Kristen/HZK-7662-2023
OI Koenen, Karestan/0000-0003-2978-7655; Nishimi,
   Kristen/0000-0001-6189-830X
FU John D. and Catherine T. MacArthur Foundation Research Network; National
   Institute on Aging [P01-AG020166, U19-AG051426]; NIH National Center for
   Advancing Translational Sciences Clinical and Translational Science
   Award program [UL1TR001409, UL1TR001881, 1UL1RR025011]; National
   Institute of Mental Health [T32 MH017119]; Lee Kum Sheung Center for
   Health and Happiness Dissertation Research Award; Department of Veterans
   Affairs Office of Academic Affiliations Advanced Fellowship Program in
   Mental Illness Research and Treatment; Medical Research Service of the
   San Francisco Veterans Affairs Healthcare System (SFVAHCS); Department
   of Veterans Affairs Sierra-Pacific Mental Illness Research, Education,
   and Clinical Center (MIRECC); NIH [ES000002]
FX We thank the staff and participants of the MIDUS Study for their
   important contributions. Publicly available data from the MIDUS study
   was used for this research. Since 1995, the MIDUS study has been funded
   by the following: John D. and Catherine T. MacArthur Foundation Research
   Network, National Institute on Aging (P01-AG020166), and National
   Institute on Aging (U19-AG051426). The biomarker data collection was
   further supported by the NIH National Center for Advancing Translational
   Sciences Clinical and Translational Science Award program as follows:
   UL1TR001409 (Georgetown), UL1TR001881 (University of California, Los
   Angeles), and 1UL1RR025011 (University of Wisconsin-Madison). K.M.N. was
   supported by National Institute of Mental Health T32 MH017119, the Lee
   Kum Sheung Center for Health and Happiness Dissertation Research Award,
   and the Department of Veterans Affairs Office of Academic Affiliations
   Advanced Fellowship Program in Mental Illness Research and Treatment,
   the Medical Research Service of the San Francisco Veterans Affairs
   Healthcare System (SFVAHCS), and the Department of Veterans Affairs
   Sierra-Pacific Mental Illness Research, Education, and Clinical Center
   (MIRECC). B.A.C. was supported by NIH ES000002.
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NR 45
TC 14
Z9 14
U1 1
U2 13
PU NATL ACAD SCIENCES
PI WASHINGTON
PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA
SN 0027-8424
J9 P NATL ACAD SCI USA
JI Proc. Natl. Acad. Sci. U. S. A.
PD AUG 10
PY 2021
VL 118
IS 32
AR e2102619118
DI 10.1073/pnas.2102619118
PG 7
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Science & Technology - Other Topics
GA UA3DV
UT WOS:000685043400016
PM 34341103
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Carbone, JT
AF Carbone, Jason T.
TI Allostatic load and mental health: a latent class analysis of
   physiological dysregulation
SO STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS
LA English
DT Article
DE Stress; depression; anhedonia; immunometabolic; parasympathetic;
   allostasis
ID POSTTRAUMATIC-STRESS-DISORDER; NECROSIS-FACTOR-ALPHA;
   RHEUMATOID-ARTHRITIS; DEPRESSIVE SYMPTOMS; METABOLIC SYNDROME;
   BIOLOGICAL RISK; NERVOUS-SYSTEM; AGE; IMMUNOMETABOLISM; PATHOPHYSIOLOGY
AB This study explored the associations between specific profiles of biological dysregulation and mental health outcomes in a national, community sample of healthy adults in the United States. A latent class analysis of data from the Midlife Development in the United States study (n = 1,757) was conducted to determine classes of biological dysregulation. Multinomial logistic regressions of class membership were employed to determine associations with measures related to depression, including whether or not individuals had sought treatment, Center for Epidemiological Studies Depression Scale, and both the generalized distress and anhedonia subscales of the Mood and Anxiety Symptoms Questionnaire. Four classes of dysregulation emerged: baseline/low dysregulation, metabolic and inflammatory dysregulation, parasympathetic dysregulation, and SAM pathway dysregulation. Individuals who met the criteria for depression measures were more likely to be in the metabolic and immune dysregulation and parasympathetic dysregulation groups as compared to the baseline group. The results suggest that mental health outcomes, such as depression, are differentially associated with specific profiles of biological dysregulation. A more nuanced approach to profiles of dysregulation could better inform treatment decisions.Lay summary Higher levels of allostatic load, which represents the cumulative wear and tear of exposure to stress, are associated with increased rates of depression and anhedonia. Specifically, parasympathetic dysregulation and immunometabolic dysregulation are associated with negative mental health outcomes
C1 [Carbone, Jason T.] Wayne State Univ, Sch Social Work, Integrat Biosci IBio Ctr, 6135 Woodward Ave, Detroit, MI 48202 USA.
C3 Wayne State University
RP Carbone, JT (corresponding author), Wayne State Univ, Sch Social Work, Integrat Biosci IBio Ctr, 6135 Woodward Ave, Detroit, MI 48202 USA.
EM jason.carbone@wayne.edu
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NR 80
TC 41
Z9 46
U1 0
U2 9
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1025-3890
EI 1607-8888
J9 STRESS
JI Stress
PD JUL 4
PY 2021
VL 24
IS 4
BP 394
EP 403
DI 10.1080/10253890.2020.1813711
EA SEP 2020
PG 10
WC Behavioral Sciences; Endocrinology & Metabolism; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Behavioral Sciences; Endocrinology & Metabolism; Neurosciences &
   Neurology
GA TD1OP
UT WOS:000566678800001
PM 32835575
DA 2025-06-11
ER

PT J
AU Kotani, K
   Sakane, N
AF Kotani, K.
   Sakane, N.
TI C-reactive Protein and Reactive Oxygen Metabolites in Subjects with
   Metabolic Syndrome
SO JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
LA English
DT Article
DE OXIDATIVE STRESS; OXYGEN REACTIVE SPECIES; INFLAMMATION;
   ATHEROSCLEROSIS; METABOLIC SYNDROME; C-REACTIVE PROTEIN; DERIVATIVES OF
   REACTIVE OXYGEN METABOLITES
ID OXIDATIVE STRESS; INFLAMMATION; BIOMARKERS; OBESITY; COMPONENTS;
   MARKERS; DAMAGE
AB OBJECTIVE: This cross-sectional study investigated the correlation between diacron reactive oxygen metabolites (d-ROMs) and high-sensitivity C-reactive protein (hs-CRP) in subjects with or without metabolic syndrome. METHODS: Cardiometabolic risk factors, d-ROMs and hs-CRP were determined in 457 women: 123 with metabolic syndrome and 334 without metabolic syndrome. The correlation between d-ROMs and hs-CRP levels was compared between the two groups. RESULTS: The group with metabolic syndrome had significantly higher d-ROMs and hs-CRP levels than the group without metabolic syndrome. While the d-ROMs level was significantly and positively correlated with the hs-CRP level in both groups, the correlation level between the two groups was significantly different. Multiple linear regression analysis adjusted for other cardiometabolic risk factors also showed significant positive correlation between d-ROMs and hs-CRP levels in both groups. CONCLUSION: Subjects with metabolic syndrome may have a closer relationship between inflammation and oxidative stress than subjects without metabolic syndrome, possibly reflecting their increased predisposition to atherosclerosis. Further studies are necessary to confirm the observed relationship.
C1 [Kotani, K.] Natl Hosp Org Kyoto Med Ctr, Clin Res Inst, Div Prevent Med, Fushimi Ku, Kyoto 6128555, Japan.
   [Kotani, K.] Jichi Med Univ, Dept Clin Lab Med, Shimotsuke, Tochigi, Japan.
C3 Jichi Medical University
RP Kotani, K (corresponding author), Natl Hosp Org Kyoto Med Ctr, Clin Res Inst, Div Prevent Med, Fushimi Ku, 1-1 Fukakusa Mukaihata, Kyoto 6128555, Japan.
EM kazukotani@jichi.ac.jp
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NR 29
TC 31
Z9 34
U1 0
U2 0
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0300-0605
EI 1473-2300
J9 J INT MED RES
JI J. Int. Med. Res.
PD MAY-JUN
PY 2012
VL 40
IS 3
BP 1074
EP 1081
DI 10.1177/147323001204000326
PG 8
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA 978CR
UT WOS:000306718600026
PM 22906280
OA gold
DA 2025-06-11
ER

PT J
AU Schulte, EC
   Schulze, TG
AF Schulte, Eva C.
   Schulze, Thomas G.
TI How do lipids fit into the picture of severe mental health disorders? A
   missing pathophysiologic link or just a consequence of behavior and
   treatment
SO EUROPEAN NEUROPSYCHOPHARMACOLOGY
LA English
DT Article
DE Lipidomics; Mental health disorders; Schizophrenia; Depression; Bipolar
   disorder; Omics
ID METABOLIC SYNDROME; ASSOCIATION; DEPRESSION
C1 [Schulte, Eva C.] Univ Bonn, Univ Hosp, Fac Med, Dept Psychiat & Psychotherapy, Bonn, Germany.
   [Schulte, Eva C.] Univ Bonn, Univ Hosp, Inst Human Genet, Fac Med, Bonn, Germany.
   [Schulte, Eva C.; Schulze, Thomas G.] Ludwig Maximilians Univ Munchen, LMU Univ Hosp, Inst Psychiat Phen & Genom, Munich, Germany.
   [Schulze, Thomas G.] Heidelberg Univ, Cent Inst Mental Hlth, Med Fac Mannheim, Dept Genet Epidemiol Psychiat, Mannheim, Germany.
   [Schulze, Thomas G.] Johns Hopkins Univ, Dept Psychiat & Behav Sci, Baltimore, MD USA.
   [Schulze, Thomas G.] SUNY Upstate Med Univ, Dept Psychiat & Behav Sci, Syracuse, NY USA.
   [Schulze, Thomas G.] German Ctr Mental Hlth DZPG, Partner Site Munich, Munich, Germany.
C3 University of Bonn; University of Bonn; University of Munich; Ruprecht
   Karls University Heidelberg; Central Institute of Mental Health; Johns
   Hopkins University; State University of New York (SUNY) System; State
   University of New York (SUNY) Upstate Medical Center
RP Schulte, EC (corresponding author), Univ Bonn, Univ Hosp, Fac Med, Dept Psychiat & Psychotherapy, Bonn, Germany.; Schulte, EC (corresponding author), Univ Bonn, Univ Hosp, Inst Human Genet, Fac Med, Bonn, Germany.; Schulte, EC (corresponding author), Ludwig Maximilians Univ Munchen, LMU Univ Hosp, Inst Psychiat Phen & Genom, Munich, Germany.
EM Eva.Schulte@med.uni-muenchen.de
RI Schulte, Eva/AAT-2410-2021
OI Schulte, Eva Christina/0000-0003-3105-5672
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NR 12
TC 0
Z9 0
U1 4
U2 8
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0924-977X
EI 1873-7862
J9 EUR NEUROPSYCHOPHARM
JI Eur. Neuropsychopharmacol.
PD JUN
PY 2024
VL 83
BP 27
EP 29
DI 10.1016/j.euroneuro.2024.02.007
EA MAR 2024
PG 3
WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA QZ0L2
UT WOS:001224572200001
PM 38518409
DA 2025-06-11
ER

PT J
AU Black, PH
AF Black, PH
TI The inflammatory response is an integral part of the stress response:
   Implications for atherosclerosis, insulin resistance, type II diabetes
   and metabolic syndrome X
SO BRAIN BEHAVIOR AND IMMUNITY
LA English
DT Review
DE stress; inflammation; acute phase response; atherosclerosis;
   insulin-resistance; diabetes type II; metabolic syndrome X; innate
   immunity
ID ACUTE-PHASE RESPONSE; C-REACTIVE PROTEIN; NECROSIS-FACTOR-ALPHA;
   ENDOTHELIUM-DEPENDENT DILATATION; DETECT CHLAMYDIA-PNEUMONIAE;
   LIPOPROTEIN-LIPASE ACTIVITY; BODY-FAT DISTRIBUTION; ADIPOSE-TISSUE;
   CORONARY-ARTERY; INNATE IMMUNITY
AB In previous publications, we presented the hypothesis that repeated episodes of acute or chronic psychological stress could induce an acute phase response (APR) and subsequently a chronic inflammatory process such as atherosclerosis. In this paper, that hypothesis, namely that such stress can induce an APR and inflammation, has been extended to include a chronic inflammatory process(s), characterized by the presence of certain cytokines and acute phase reactants (APR), which is associated with certain metabolic diseases. The loci of origin of these cytokines, particularly interleukin 6 (IL-6), and their induction, has been considered. Evidence is presented that the liver, the endothelium, and fat cell depots are the primary sources of cytokines, particularly IL-6, and that IL-6 and the acute phase protein (APP), C-reactive protein (CRP), are strongly associated with, and likely play a dominant role in, the development of this inflammatory process which leads to insulin resistance, non-insulin dependent diabetes mellitus type 11, and Metabolic syndrome X. The possible role of psychological stress and the major stress-related hormones as etiologic factors in the pathogenesis of these metabolic diseases, as well as atherosclerosis, is discussed. The fact that stress can activate an APR, which is part of the innate immune inflammatory response, is evidence that the inflammatory response is contained within the stress response or that stress can induce an inflammatory response. The evidence that the stress, inflammatory, and immune systems all evolved from a single cell, the phagocyte, is further evidence for their intimate relationship which almost certainly was maintained throughout evolution. (C) 2003 Elsevier Inc. All rights reserved.
C1 Boston Univ, Sch Med, Dept Microbiol, Boston, MA 02118 USA.
C3 Boston University
RP Boston Univ, Sch Med, Dept Microbiol, 715 Albany St,Room L-504, Boston, MA 02118 USA.
EM pblack@bu.edu
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NR 137
TC 374
Z9 447
U1 0
U2 37
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0889-1591
EI 1090-2139
J9 BRAIN BEHAV IMMUN
JI Brain Behav. Immun.
PD OCT
PY 2003
VL 17
IS 5
BP 350
EP 364
DI 10.1016/S0889-1591(03)00048-5
PG 15
WC Immunology; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Immunology; Neurosciences & Neurology; Psychiatry
GA 719TG
UT WOS:000185220300005
PM 12946657
DA 2025-06-11
ER

PT J
AU Bergmann, N
   Ballegaard, S
   Krogh, J
   Bech, P
   Hjalmarson, Å
   Gyntelberg, F
   Faber, J
AF Bergmann, Natasha
   Ballegaard, Soren
   Krogh, Jesper
   Bech, Per
   Hjalmarson, Ake
   Gyntelberg, Finn
   Faber, Jens
TI Chronic psychological stress seems associated with elements of the
   metabolic syndrome in patients with ischaemic heart disease
SO SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION
LA English
DT Article
DE Metabolic syndrome; ischaemic heart disease; stress; depression;
   wellbeing; cholesterol; body fat
ID PRESSURE PAIN SENSITIVITY; MAJOR DEPRESSION; RISK-FACTORS; METAANALYSIS;
   SYMPTOMS; INDIVIDUALS; LIFE
AB Background and objectives: Chronic psychological stress, the metabolic syndrome (MS) and ischaemic heart disease (IHD) seem closely connected. In this study, we evaluate the association between chronic stress and elements of MS in patients with stable IHD.Design: Cross-sectional cohort study.Methods: Three hundred and fifty patients with stable IHD were included. Chronic stress was evaluated by the two questionnaires, Major Depression Inventory (MDI) and the psychological wellbeing index WHO-5, as well as by Pressure Pain Sensitivity (PPS), a physiological measure of hyperalgesia at the sternum known to be associated to elements of the chronic stress syndrome. Elements of MS were evaluated by dual-energy X-ray absorptiometry, body weight, HOMA-IR and blood lipids.Results: Depressive symptoms were associated with a high percentage of body fat (=0.179, p=.001), and high level of triglycerides (=0.150, p=.007). Low psychological wellbeing was associated with a high percentage of body fat (=-0.165, p=.002) and low level of HDL cholesterol (=0.128, p=.024). Chronic stress measured by PPS was associated with a high percentage body fat (=0.327, p<.001), low body weight (=-0.218, p<.001) and low HDL-cholesterol (=-0.137, p=.013). Adjusting for several life style factors did not change these results.Conclusions: In patients with stable IHD, different measures of chronic psychological stress seem associated with a high percentage of body fat and adverse blood lipids independent of several lifestyle factors.
C1 [Bergmann, Natasha; Krogh, Jesper; Faber, Jens] Univ Copenhagen, Herlev Hosp, Dept Endocrinol, Herlev Ringvej 75, DK-2730 Herlev, Denmark.
   [Bergmann, Natasha] Univ Copenhagen, Gentofte Hosp, Ctr Diabet Res, Kildegardsvej 28, DK-2900 Hellerup, Denmark.
   [Ballegaard, Soren] Ull Care AS, Hellerup, Denmark.
   [Bech, Per] Psychiat Ctr North Zealand, Psychiat Res Unit, Hillerod, Denmark.
   [Hjalmarson, Ake] Sahlgrens Univ Hosp, Dept Cardiol, Gothenburg, Sweden.
   [Gyntelberg, Finn] Natl Res Ctr Working Environm, Copenhagen, Denmark.
   [Faber, Jens] Univ Copenhagen, Fac Hlth & Med Sci, Copenhagen, Denmark.
C3 University of Copenhagen; University of Copenhagen; Herlev & Gentofte
   Hospital; Sahlgrenska University Hospital; National Research Centre for
   the Working Environment; University of Copenhagen
RP Bergmann, N (corresponding author), Univ Copenhagen, Herlev Hosp, Dept Endocrinol, Herlev Ringvej 75, DK-2730 Herlev, Denmark.; Bergmann, N (corresponding author), Univ Copenhagen, Gentofte Hosp, Ctr Diabet Res, Kildegardsvej 28, DK-2900 Hellerup, Denmark.
EM Natasha.chidekel.bergmann@regionh.dk
RI Krogh, Jesper/C-6876-2013
OI Bech, Per/0000-0002-4948-6115; Bergmann, Natasha
   Chidekel/0000-0002-6797-8041; Krogh, Jesper/0000-0003-4834-6724;
   Gyntelberg, Finn/0000-0002-1339-0998
FU Johan Schroder's Family and Business Foundation; Lundbeck Foundation;
   Else and Mogens Wedell-Wedellsborg's Foundation and Carpenter Sophus
   Jacobsen and Wife Astrid Jacobsen's Foundation
FX This work was supported by the Johan Schroder's Family and Business
   Foundation, the Lundbeck Foundation, Else and Mogens
   Wedell-Wedellsborg's Foundation and Carpenter Sophus Jacobsen and Wife
   Astrid Jacobsen's Foundation.
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NR 35
TC 7
Z9 7
U1 0
U2 6
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0036-5513
EI 1502-7686
J9 SCAND J CLIN LAB INV
JI Scand. J. Clin. Lab. Invest.
PY 2017
VL 77
IS 7
BP 513
EP 519
DI 10.1080/00365513.2017.1354254
PG 7
WC Medical Laboratory Technology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Medical Laboratory Technology; Research & Experimental Medicine
GA FF8OG
UT WOS:000409277100006
PM 28727492
DA 2025-06-11
ER

PT J
AU Gelfandt, EV
   Cannon, CP
AF Gelfandt, EV
   Cannon, CP
TI Rimonabant: a selective blocker of the cannabinoid CB1 receptors for the
   management of obesity, smoking cessation and cardiometabolic risk
   factors
SO EXPERT OPINION ON INVESTIGATIONAL DRUGS
LA English
DT Article
DE endocannabinoids; metabolic syndrome; obesity; rimonabant; smoking;
   SR-141716
ID DIET-INDUCED OBESITY; ENDOGENOUS CANNABINOIDS; MYOCARDIAL-INFARCTION;
   OVERWEIGHT PATIENTS; ANTAGONIST; MORTALITY; ANANDAMIDE; NICOTINE;
   SEEKING; WEIGHT
AB Rimonabant is the first selective blocker of the cannabinoid CB1 receptors being developed for the treatment of obesity, tobacco smoking and cardiometabolic risk factors. Following 1 year of treatment, rimonabant 20 mg/day leads to greater weight loss compared with placebo. Therapy with rimonabant is also associated with favourable changes in serum lipids and an improvement in glycaemic control in Type 2 diabetics. At the same dose, rimonabant significantly increases the cigarette smoking quit rates compared with placebo. Rimonabant appears to be generally well tolerated, with primary side effects of mild nausea, diarrhoea, anxiety and depression. As an agent with a novel mechanism of action, rimonabant has the potential to be a useful adjunct to lifestyle modification in the treatment of obesity, metabolic syndrome and cigarette smoking.
C1 Beth Israel Deaconess Med Ctr, Div Cardiol, Boston, MA 02215 USA.
C3 Harvard University; Harvard University Medical Affiliates; Beth Israel
   Deaconess Medical Center
RP Beth Israel Deaconess Med Ctr, Div Cardiol, Baker 4,1 Deaconess Rd, Boston, MA 02215 USA.
EM egelfand@bidmc.harvard.edu
RI Cannon, Christopher/AAY-7644-2020
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NR 72
TC 53
Z9 56
U1 0
U2 4
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1354-3784
EI 1744-7658
J9 EXPERT OPIN INV DRUG
JI Expert Opin. Investig. Drugs
PD MAR
PY 2006
VL 15
IS 3
BP 307
EP 315
DI 10.1517/13543784.15.3.307
PG 9
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 020QY
UT WOS:000235926400012
PM 16503766
DA 2025-06-11
ER

PT J
AU Akdag Cirik, D
   Dilbaz, B
   Aksakal, S
   Kotan, Z
   Özelçi, R
   Akpinar, F
   Mollamahmutoglu, L
AF Akdag Cirik, Derya
   Dilbaz, Berna
   Aksakal, Sezin
   Kotan, Zeynep
   Ozelci, Runa
   Akpinar, Funda
   Mollamahmutoglu, Leyla
TI Do anxiety and depression statuses differ in different polycystic ovary
   syndrome phenotypes?
SO TURKISH JOURNAL OF MEDICAL SCIENCES
LA English
DT Article
DE Anxiety; depression; polycystic ovary syndrome; phenotype; quality of
   life
ID QUALITY-OF-LIFE; CARDIOMETABOLIC RISK; WOMEN; HEALTH; DISORDERS;
   TESTOSTERONE; PREVALENCE; PARAMETERS; MOOD
AB Background/aim: To evaluate psychological parameters and health quality profiles in women with reproductive polycystic ovary syndrome (PCOS) phenotypes and age matched controls.
   Materials and methods: The study groups included 101 women with PCOS (54 with the National Institutes of Health [NIH] phenotype and 47 with the non-NIH phenotype) and 49 healthy female controls. The participants completed anxiety and depression scales and four quality of life domains.
   Results: We identified the women with PCOS as having a 3.39 times increased risk for depression (subscale >= 7) and a 3.64 times increased risk for anxiety (subscale >= 10) compared to the controls. Both NIH and non-NIH phenotypes showed similar rates of depression (46.3% vs. 46.8%, respectively; P = 0.57) and anxiety (31.5% vs. 36.2%, respectively; P = 0.47). Regarding the quality of life scale, the women with NIH PCOS had significantly lower mental health scores compared to those with non-NIH PCOS (P = 0.03). Furthermore, while mental health scores were similar in the women with PCOS and the controls, physical health scores were significantly lower in the women with PCOS (P = 0.007).
   Conclusion: Nearly half of the women with PCOS had higher depression scores and one third had higher anxiety scores. Thus, psychiatric evaluations appear necessary for PCOS patients in order to diagnose and treat clinical depression and anxiety.
C1 [Akdag Cirik, Derya; Dilbaz, Berna; Aksakal, Sezin; Ozelci, Runa; Akpinar, Funda; Mollamahmutoglu, Leyla] Etlik Zubeyde Hanim Womens Hlth Training & Res H, Dept Reprod Med & Infertil, Ankara, Turkey.
   [Kotan, Zeynep] Abdurrahman Yurtaslan Oncol Training & Res Hosp, Dept Psychiat, Ankara, Turkey.
C3 Etlik Zubeyde Hanim Gynecology Education & Research Hospital; Dr.
   Abdurrahman Yurtaslan Oncology Hospital
RP Aksakal, S (corresponding author), Etlik Zubeyde Hanim Womens Hlth Training & Res H, Dept Reprod Med & Infertil, Ankara, Turkey.
EM drsezert@gmail.com
RI DİLBAZ, BERNA/AAC-5818-2019; Erturk Aksakal, Sezin/GLR-9774-2022;
   AKPINAR, FUNDA/AAN-4674-2021
OI Erturk Aksakal, Sezin/0000-0002-4418-7319; Dilbaz,
   Berna/0000-0003-1137-8650
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NR 34
TC 7
Z9 7
U1 1
U2 11
PU Tubitak Scientific & Technological Research Council Turkey
PI ANKARA
PA ATATURK BULVARI NO 221, KAVAKLIDERE, TR-06100 ANKARA, TURKIYE
SN 1300-0144
EI 1303-6165
J9 TURK J MED SCI
JI Turk. J. Med. Sci.
PY 2016
VL 46
IS 6
BP 1846
EP 1853
DI 10.3906/sag-1511-112
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA EJ6LN
UT WOS:000393331000038
PM 28081337
OA Bronze
DA 2025-06-11
ER

PT J
AU Ai, AL
   Kabbaj, M
   Kathy, LL
AF Ai, Amy L.
   Kabbaj, Mohamed
   Kathy, Lee L.
TI Body affects mind? Preoperative behavioral and biological predictors for
   postoperative symptoms in mental health
SO JOURNAL OF BEHAVIORAL MEDICINE
LA English
DT Article
DE Postoperative depressed mood, anxiety, and hostility; Preoperative
   plasma interleukin-6; C-reactive protein, and cortisol; Hope; Cardiac
   diseases; Cardiac surgery
ID CORONARY-HEART-DISEASE; C-REACTIVE PROTEIN; CORTISOL AWAKENING RESPONSE;
   METABOLIC SYNDROME; MAJOR DEPRESSION; PLASMA-CORTISOL; CHRONIC STRESS;
   CYTOKINES; ASSOCIATION; ANXIETY
AB The study examined differential effects of preoperative biomarkers (cotisol, C-reactive protein/CRP, and interleukin-6/IL-6) on postoperative symptoms in mental health (depressed mood, anxiety and hostility) 1 month following open-heart surgery, controlling for known predictors. Preoperative and postoperative interviews were conducted on 162 patients. Peripheral venous blood samples were collected between 8 and 10 a.m. prior to surgery. Cardiac indices were obtained from the Society of Thoracic Surgeons' national database. Preoperative anxiety contributed to all outcomes about 1 month postoperatively. Patients with high preoperative plasma IL-6 used more avoidant coping and experienced greater depressed mood. Patients with increased plasma CRP and with hope were less depressed. Elevated plasma cortisol predicted hostility. Finally, medical comorbidities predicted anxiety and hostility. The combination of anxiety and stress-sensitive biomarkers may be one way to predict postoperative symptoms following open-heart surgery. Our findings emphasize the importance of investigating the mind-body interplay to come up with better interventions.
C1 [Ai, Amy L.] Florida State Univ, Coll Social Work, Dept Psychol, Tallahassee, FL 32306 USA.
   [Kabbaj, Mohamed; Kathy, Lee L.] Florida State Univ, Coll Med, Tallahassee, FL 32306 USA.
C3 State University System of Florida; Florida State University; State
   University System of Florida; Florida State University
RP Ai, AL (corresponding author), Florida State Univ, Coll Social Work, Dept Psychol, 2313 Univ Ctr Bldg C, Tallahassee, FL 32306 USA.
EM aai@fsu.edu; mohamed.kabbaj@med.fsu.edu; kathy.lee@med.fsu.edu
RI Kabbaj, Mohamed/M-9240-2016; kathy, Lee/JBS-5548-2023
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NR 74
TC 12
Z9 14
U1 0
U2 11
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0160-7715
EI 1573-3521
J9 J BEHAV MED
JI J. Behav. Med.
PD APR
PY 2014
VL 37
IS 2
BP 289
EP 299
DI 10.1007/s10865-012-9484-3
PG 11
WC Psychology, Clinical
WE Social Science Citation Index (SSCI)
SC Psychology
GA AC7EF
UT WOS:000332689300011
PM 23274763
DA 2025-06-11
ER

PT J
AU Geraets, AFJ
   Schram, MT
   Jansen, JFA
   Backes, WH
   Schalkwijk, CG
   Stehouwer, CDA
   van Boxtel, MPJ
   Eussen, SJPM
   Kooman, JP
   Verhey, FRJ
   Kohler, S
AF Geraets, Anouk F. J.
   Schram, Miranda T.
   Jansen, Jacobus F. A.
   Backes, Walter H.
   Schalkwijk, Casper G.
   Stehouwer, Coen D. A.
   van Boxtel, Martin P. J.
   Eussen, Simone J. P. M.
   Kooman, Jeroen P.
   Verhey, Frans R. J.
   Kohler, Sebastian
TI The cardiometabolic depression subtype and its association with clinical
   characteristics: The Maastricht Study
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Major depressive disorder; Depression; Cardiometabolic abnormalities;
   Metabolic syndrome; Epidemiology; Latent class analysis
ID PARTICIPANTS AGED 24-81; LATENT CLASS ANALYSIS; SMALL VESSEL DISEASE;
   LATE-LIFE DEPRESSION; NORMATIVE DATA; METABOLIC SYNDROME; EDUCATION;
   ANTIDEPRESSANTS; METAANALYSIS; INSTRUMENTS
AB Background: Individuals with depression often show an adverse cardiometabolic risk profile and might represent a distinct depression subtype. The aim of this study was to investigate whether a cardiometabolic depression subtype could be identified and to investigate its association with demographics and clinical characteristics (severity, symptomatology, anti-depressant use, persistence and cognitive functioning). Methods: We used data from The Maastricht Study, a population-based cohort in the southern part of The Netherlands. A total of 248 participants with major depressive disorder were included (mean [SD] age, 58.8 +/- 8.5 years; 121 [48.8 %] were men). Major depressive disorder was assessed at baseline by the Mini-International Neuropsychiatric Interview. Cardiometabolic risk factors were defined as indicators of the metabolic syndrome according to the National Cholesterol Education Program Adult Treatment Panel III guidelines. We measured severity and persistence of depressive symptoms by use of the 9-item Patient Health Questionnaire. Results: Latent class analysis resulted in two subtypes, one with cardiometabolic depression (n = 145) and another with non-cardiometabolic depression (n = 103). The cardiometabolic depression subtype was charac-terized by being male, low education, more severe depressive symptoms, less symptoms of depressed mood and more symptoms of loss of energy, more use of antidepressant medication and lower cognitive functioning. Limitations: No conclusions can be made about causality. Conclusions: Latent class analysis suggested a distinct cardiometabolic depression subtype. Participants with cardiometabolic depression differed from participants with non-cardiometabolic depression in terms of de-mographics and clinical characteristics. The existence of a cardiometabolic depression subtype may indicate the need for prevention and treatment targeting cardiometabolic risk management.
C1 [Geraets, Anouk F. J.; van Boxtel, Martin P. J.; Verhey, Frans R. J.; Kohler, Sebastian] Maastricht Univ Med Ctr MUMC, Alzheimer Ctr Limburg, Maastricht, Netherlands.
   [Geraets, Anouk F. J.; Schram, Miranda T.; van Boxtel, Martin P. J.; Verhey, Frans R. J.; Kohler, Sebastian] Maastricht Univ Med Ctr MUMC, Dept Psychiat & Neuropsychol, Maastricht, Netherlands.
   [Geraets, Anouk F. J.; Schram, Miranda T.; Schalkwijk, Casper G.; Stehouwer, Coen D. A.; Kooman, Jeroen P.] Maastricht Univ Med Ctr MUMC, Dept Internal Med, Maastricht, Netherlands.
   [Schram, Miranda T.] Maastricht Univ Med Ctr MUMC, Heart & Vasc Ctr, Maastricht, Netherlands.
   [Jansen, Jacobus F. A.; Backes, Walter H.] Maastricht Univ Med Ctr MUMC, Dept Radiol, Maastricht, Netherlands.
   [Eussen, Simone J. P. M.] Maastricht Univ Med Ctr MUMC, Dept Epidemiol, Maastricht, Netherlands.
   [Geraets, Anouk F. J.; Schram, Miranda T.; Jansen, Jacobus F. A.; Backes, Walter H.; van Boxtel, Martin P. J.; Verhey, Frans R. J.; Kohler, Sebastian] Maastricht Univ, Fac Hlth Med & Life Sci, Sch Mental Hlth & Neurosci MHeNs, Maastricht, Netherlands.
   [Geraets, Anouk F. J.; Schram, Miranda T.; Schalkwijk, Casper G.; Stehouwer, Coen D. A.; Eussen, Simone J. P. M.; Kooman, Jeroen P.] Maastricht Univ, Fac Hlth Med & Life Sci, Sch Cardiovasc Dis CARIM, Maastricht, Netherlands.
   [Kohler, Sebastian] Maastricht Univ & Maastricht UMC, Alzheimer Ctr Limburg, Sch Mental Hlth & Neurosci, POB 616, NL-6200 MD Maastricht, Netherlands.
C3 Maastricht University; Maastricht University Medical Centre (MUMC);
   Maastricht University; Maastricht University Medical Centre (MUMC);
   Maastricht University; Maastricht University Medical Centre (MUMC);
   Maastricht University; Maastricht University Medical Centre (MUMC);
   Maastricht University; Maastricht University Medical Centre (MUMC);
   Maastricht University; Maastricht University Medical Centre (MUMC);
   Maastricht University; Maastricht University; Maastricht University
RP Kohler, S (corresponding author), Maastricht Univ & Maastricht UMC, Alzheimer Ctr Limburg, Sch Mental Hlth & Neurosci, POB 616, NL-6200 MD Maastricht, Netherlands.
EM s.koehler@maastrichtuniversity.nl
RI Jansen, Jacobus/C-4098-2009; eussen, simone/JAC-5744-2023; Stehouwer,
   Coen/AAB-3435-2021; Geraets, Anouk/ACI-9551-2022
OI Eussen, Simone/0000-0003-0559-6838; Schalkwijk, Casper
   G/0000-0003-0190-2690; Stehouwer, Coen/0000-0001-8752-3223; Geraets,
   Anouk/0000-0002-2648-4424
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NR 52
TC 7
Z9 6
U1 0
U2 12
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD SEP 15
PY 2022
VL 313
BP 110
EP 117
DI 10.1016/j.jad.2022.06.045
EA JUL 2022
PG 8
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA 5W4JI
UT WOS:000877882000002
PM 35779670
OA Green Published
DA 2025-06-11
ER

PT J
AU Hildrum, B
   Mykletun, A
   Midthjell, K
   Ismail, K
   Dahl, AA
AF Hildrum, B.
   Mykletun, A.
   Midthjell, K.
   Ismail, K.
   Dahl, A. A.
TI No association of depression and anxiety with the metabolic syndrome:
   the Norwegian HUNT study
SO ACTA PSYCHIATRICA SCANDINAVICA
LA English
DT Article
DE anxiety; depression; epidemiology; metabolic syndrome
ID TYPE-2 DIABETES-MELLITUS; PHOBIC ANXIETY; BLOOD-PRESSURE; YOUNG-ADULTS;
   RISK-FACTOR; POPULATION; LIFE; HEALTH; DISORDERS; MORTALITY
AB Objective: To examine the associations of depression and anxiety with the metabolic syndrome.
   Method: Cross-sectional study of 9571 participants aged 20-89 years in the Nord-Trondelag Health Study (HUNT 2). We assessed anxiety and depression with the Hospital Anxiety and Depression Scale and the metabolic syndrome with the International Diabetes Federation criteria.
   Results: Despite generous statistical power and use of both continuous and categorical approaches, we found no association between anxiety or depression and the metabolic syndrome in models adjusted for age, gender, educational level, smoking, physical activity and pulse rate. When adjusted for age and gender only, we found a weak positive association for depression when a continuous measure was used, but not at the case level. The findings were similar across sexes, and robust for exclusion of cardiovascular disease and antidepressants.
   Conclusion: In this largest study to date we found no association of anxiety and depression with the metabolic syndrome.
C1 [Hildrum, B.] Namsos Hosp, Dept Psychiat, Nord Trondelag Hosp Irust, N-7800 Namsos, Norway.
   [Hildrum, B.] Norwegian Univ Sci & Technol, Fac Med, Dept Neurosci, N-7034 Trondheim, Norway.
   [Mykletun, A.] Univ Bergen, Fac Psychol, Res Ctr Hlth Promot, Bergen, Norway.
   [Mykletun, A.] Norwegian Inst Publ Hlth, Div Mental Hlth, Oslo, Norway.
   [Midthjell, K.] Norwegian Univ Sci & Technol, HUNT Res Ctr, Dept Publ Hlth & Gen Practice, Verdal, Norway.
   [Ismail, K.] Kings Coll London, Dept Psychol Med, Inst Psychiat, London WC2R 2LS, England.
   [Dahl, A. A.] Univ Clin, Rikshosp, Norwegian Radium Hosp, Dept Clin Canc Res, Oslo, Norway.
   [Dahl, A. A.] Univ Oslo, Fac Div, Norwegian Radium Hosp, Oslo, Norway.
C3 Norwegian University of Science & Technology (NTNU); University of
   Bergen; Norwegian Institute of Public Health (NIPH); Norwegian
   University of Science & Technology (NTNU); University of London; King's
   College London; University of Oslo; National Hospital Norway; University
   of Oslo
RP Hildrum, B (corresponding author), Namsos Hosp, Dept Psychiat, Nord Trondelag Hosp Irust, N-7800 Namsos, Norway.
EM bjorn.hildrum@hnt.no
RI ; Mykletun, Arnstein/L-5004-2015
OI Ismail, Khalida/0000-0001-6084-449X; Mykletun,
   Arnstein/0000-0002-3878-0079
FU HUNT Research Centre at the Faculty of Medicine; Norwegian University of
   Science and Technology (NTNU); Norwegian Institute of Public Health;
   Nord-Trondelag County Council
FX The HUNT study is a collaboration between the HUNT Research Centre at
   the Faculty of Medicine, Norwegian University of Science and Technology
   (NTNU), the Norwegian Institute of Public Health, and the Nord-Trondelag
   County Council.
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NR 39
TC 85
Z9 89
U1 0
U2 13
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0001-690X
EI 1600-0447
J9 ACTA PSYCHIAT SCAND
JI Acta Psychiatr. Scand.
PD JUL
PY 2009
VL 120
IS 1
BP 14
EP 22
DI 10.1111/j.1600-0447.2008.01315.x
PG 9
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 453TP
UT WOS:000266636100003
PM 19120047
DA 2025-06-11
ER

PT J
AU Leung, LYL
   Chan, AWK
   Sit, JWH
   Liu, T
   Taylor-Piliae, RE
AF Leung, Leona Yuen-ling
   Chan, Aileen Wai-kiu
   Sit, Janet Wing-hung
   Liu, Ting
   Taylor-Piliae, Ruth E.
TI Tai Chi in Chinese adults with metabolic syndrome: A pilot randomized
   controlled trial
SO COMPLEMENTARY THERAPIES IN MEDICINE
LA English
DT Article
DE Cardiometabolic risk factors; Metabolic syndrome; Quality of life; Tai
   Chi
ID TIME PHYSICAL-ACTIVITY; QUALITY-OF-LIFE; BLOOD-PRESSURE; OLDER-ADULTS;
   EXERCISE; PROGRAM; HEALTH; METAANALYSIS; WEIGHT; WOMEN
AB Objective: To determine the feasibility, acceptability and effects of a 12-week Tai Chi exercise program on cardiometabolic risk factors and quality of life in community-dwelling Chinese adults with metabolic syndrome.
   Design: A single blind, pilot randomized controlled trial.
   Setting/location: A general outpatient clinic of a community-based hospital in Hong Kong.
   Subjects: Ethnic Chinese, 18 years and older, who had at least three of the five criteria of metabolic syndrome defined by the National Cholesterol Education- Adult Treatment Panel III.
   Intervention: The Tai Chi group attended a 1-h Tai Chi class, twice a week for 12 weeks, plus 30-minutes home practice three-times per week. The control group maintained their usual daily activities.
   Outcome measures: Primary outcomes were feasibility and acceptability of the Tai Chi intervention. Secondary outcome measures were cardiometabolic risk factors, quality of life, stress and Tai Chi exercise self-efficacy.
   Results: Study retention rate was 65% (n = 35). Overall satisfaction of completers with the Tai Chi intervention was 4.5 +/- 0.63 (possible range = 1-5). When compared to controls, the Tai Chi group had significantly lower systolic blood pressure (p = 0.037) at 12-weeks. Significant within group changes for the Tai Chi group included lower diastolic blood pressure (p = 0.015), higher fasting blood glucose (p = 0.009), higher waist circumference (females only, p = 0.007), and better perceived mental health (p = 0.046); while controls had significantly higher fasting blood glucose (p = 0.031), and higher waist circumference (females only, p = 0.003).
   Conclusion: The study intervention was feasible and acceptable for Chinese adults with metabolic syndrome. While not powered to find statistically significant differences, positive and negative changes were observed in some cardiometabolic risk factors and quality of life. Further investigation with a larger sample size and longer study period is needed to explore potential environmental factors that may have influenced the study results.
C1 [Leung, Leona Yuen-ling] Kiang Wu Nursing Coll Macau, Est Repouso 35 R-C, Macau, Peoples R China.
   [Chan, Aileen Wai-kiu; Sit, Janet Wing-hung] Chinese Univ Hong Kong, Nethersole Sch Nursing, Shatin, 7th Floor,Esther Lee Bldg, Hong Kong, Peoples R China.
   [Liu, Ting] Chinese Univ Hong Kong, Nethersole Sch Nursing, Shatin, 6th Floor,Esther Lee Bldg, Hong Kong, Peoples R China.
   [Taylor-Piliae, Ruth E.] Univ Arizona, Coll Nursing, 1305 N Martin,POB 210203, Tucson, AZ 85721 USA.
C3 Kiang Wu Nursing College of Macau; Chinese University of Hong Kong;
   Chinese University of Hong Kong; University of Arizona
RP Chan, AWK (corresponding author), Chinese Univ Hong Kong, Nethersole Sch Nursing, Shatin, Rm727,Esther Lee Bldg, Hong Kong, Peoples R China.
EM leonaleung@kwnc.edu.mo; aileenchan@cuhk.edu.hk; janet.sit@cuhk.edu.hk;
   liuting@link.cuhk.edu.hk; rtaylor@nursing.arizona.edu
RI Leung, Leona/AHE-8456-2022; Sit, Janet/A-5159-2015; Chan,
   Aileen/A-4065-2015
OI LIU, Ting/0000-0002-8248-2968; Leung, Yuen Ling/0000-0003-2704-7805
FU Technological and Higher Education Institute of Hong Kong [14151109]
FX This study was funded by a seed grant scheme from the Technological and
   Higher Education Institute of Hong Kong (project number: 14151109).
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NR 44
TC 20
Z9 24
U1 3
U2 26
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0965-2299
EI 1873-6963
J9 COMPLEMENT THER MED
JI Complement. Ther. Med.
PD OCT
PY 2019
VL 46
BP 54
EP 61
DI 10.1016/j.ctim.2019.07.008
PG 8
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Integrative & Complementary Medicine
GA JB1KR
UT WOS:000488319900010
PM 31519288
OA Green Published
DA 2025-06-11
ER

PT J
AU Kim, CJ
   Kim, DJ
   Park, HR
AF Kim, Chun-Ja
   Kim, Dae-Jung
   Park, Hyung-Ran
TI Effects of a Cardiovascular Risk Reduction Intervention With
   Psychobehavioral Strategies for Korean Adults With Type 2 Diabetes and
   Metabolic Syndrome
SO JOURNAL OF CARDIOVASCULAR NURSING
LA English
DT Article
DE behavioral research; cardiometabolic risk; diabetes; exercise; metabolic
   syndrome X
ID CORONARY-HEART-DISEASE; RANDOMIZED CONTROLLED-TRIAL; ALL-CAUSE
   MORTALITY; PHYSICAL-ACTIVITY; SELF-CARE; EXERCISE BEHAVIOR; GLYCEMIC
   CONTROL; MYOCARDIAL-INFARCTION; MEDICATION ADHERENCE; DEPRESSIVE
   SYMPTOMS
AB Background: Type 2 diabetes mellitus (DM) and metabolic syndrome are associated with high risk of cardiovascular disease (CVD) and depression. Although lifestyle modifications including regular exercise and weight control are recommended as a primary approach to glycemic control and CVD risk reduction for people with DM and/or metabolic syndrome, little is known concerning the effects of CVD risk reduction interventions using psychobehavioral strategies in this population. Objective: This pilot study investigated the effects of a 16-week CVD risk reduction intervention in Korean adults with type 2 DM and metabolic syndrome. Methods: A prospective, pretest and posttest, controlled, quasi-experimental design enrolled a convenience sample of 43 Korean adults with type 2 DM and metabolic syndrome at a university hospital. The adults in the intervention group participated in a 16-week CVD risk reduction intervention consisting of 150 minutes of regular exercise per week; 200- to 300-kcal reduced daily diet for weight control; one-on-one psychobehavioral counseling based on constructs from the Transtheoretical Model such as processes of change, self-efficacy, and decisional balance; and telephone coaching for behavioral modification. Participants in the control group received a booklet with basic diabetic education as part of their routine care. Repeated-measures analysis of variance was used for analyzing the effects of the CVD risk reduction intervention on cardiometabolic risk factors including the UK Prospective Diabetes Study score for 10-year CVD risk, glycated hemoglobin (HbA(1c)), and depression. Results: The intervention group showed significant reductions (P < .05) at 16 weeks, compared with the control group on the UK Prospective Diabetes Study fatal risk scale (-1.73% vs -0.04%), triglycerides (-38.5 vs -15.1 mg/dL), fasting plasma glucose (-29.24 vs +1.77 mg/dL), HbA(1c) (-0.37% vs +0.17%), and depression (score, -3.24 vs 1.40) measurements. Conclusions: This pilot study yielded evidence for the beneficial impact of the CVD risk reduction intervention for Korean adults with type 2 DM and metabolic syndrome on improved glycemic control, reduced CVD risk, and depression.
C1 [Kim, Chun-Ja] Ajou Univ, Coll Nursing, Dept Adult Hlth Nursing, Suwon 443721, South Korea.
   [Kim, Dae-Jung] Ajou Univ, Dept Endocrinol & Metab, Sch Med, Suwon 443721, South Korea.
   [Park, Hyung-Ran] Korea Univ, Dept Adult Hlth Nursing, Coll Nursing, Seoul, South Korea.
C3 Ajou University; Ajou University; Korea University
RP Kim, CJ (corresponding author), Ajou Univ, Coll Nursing, Dept Adult Hlth Nursing, Songjaekwan 10th F,San 5, Suwon 443721, South Korea.
EM ckimha@ajou.ac.kr
RI Kim, Dae/AAJ-7518-2021; Kim, Chun-Ja/HKF-2429-2023
OI KIM, Chun-Ja/0000-0002-7594-5418; Kim, Dae Jung/0000-0003-1025-2044
FU Korean Government (MOEHRD) [KRF-2007-531-E00087]; Department of Nursing,
   Graduate School, Ajou University
FX This work was supported by a Korea Research Foundations grant funded by
   the Korean Government (MOEHRD, Basic Research Promotion Fund)
   (KRF-2007-531-E00087) to C.J.K. and a grant in 2008 from Department of
   Nursing, Graduate School, Ajou University to C.J.K.
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NR 62
TC 27
Z9 35
U1 0
U2 14
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0889-4655
EI 1550-5049
J9 J CARDIOVASC NURS
JI J. Cardiovasc. Nurs.
PD MAR-APR
PY 2011
VL 26
IS 2
BP 117
EP 128
DI 10.1097/JCN.0b013e3181ec02ae
PG 12
WC Cardiac & Cardiovascular Systems; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Cardiovascular System & Cardiology; Nursing
GA 719XJ
UT WOS:000287244500005
PM 21076316
DA 2025-06-11
ER

PT J
AU Azar, KMJ
   Koliwad, S
   Poon, T
   Xiao, L
   Lv, N
   Griggs, R
   Ma, J
AF Azar, Kristen M. J.
   Koliwad, Suneil
   Poon, Tak
   Xiao, Lan
   Lv, Nan
   Griggs, Robert
   Ma, Jun
TI The Electronic CardioMetabolic Program (eCMP) for Patients With
   Cardiometabolic Risk: A Randomized Controlled Trial
SO JOURNAL OF MEDICAL INTERNET RESEARCH
LA English
DT Article
DE prevention; lifestyle; metabolic syndrome; cardiovascular disease;
   behavior change; health technology
ID WEIGHT-LOSS INTERVENTIONS; LIFE-STYLE INTERVENTIONS; HEALTH
   INFORMATION-TECHNOLOGY; DIABETES PREVENTION PROGRAM; PHYSICAL-ACTIVITY;
   PRIMARY-CARE; METABOLIC SYNDROME; OBESE ADULTS; MANAGEMENT; STRESS
AB Background: Effective lifestyle interventions targeting high-risk adults that are both practical for use in ambulatory care settings and scalable at a population management level are needed.
   Objective: Our aim was to examine the potential effectiveness, feasibility, and acceptability of delivering an evidence-based Electronic Cardio-Metabolic Program (eCMP) for improving health-related quality of life, improving health behaviors, and reducing cardiometabolic risk factors in ambulatory care high-risk adults.
   Methods: We conducted a randomized, wait-list controlled trial with 74 adults aged >= 18 years recruited from a large multispecialty health care organization. Inclusion criteria were (1) BMI >= 35 kg/m(2) and prediabetes, previous gestational diabetes and/or metabolic syndrome, or (2) BMI >= 30 kg/m(2) and type 2 diabetes and/or cardiovascular disease. Participants had a mean age of 59.7 years (SD 11.2), BMI 37.1 kg/m(2) (SD 5.4) and were 59.5% female, 82.4% white. Participants were randomized to participate in eCMP immediately (n= 37) or 3 months later (n= 37). eCMP is a 6-month program utilizing video conferencing, online tools, and pre-recorded didactic videos to deliver evidence-based curricula. Blinded outcome assessments were conducted at 3 and 6 months postbaseline. Data were collected and analyzed between 2014 and 2015. The primary outcome was health-related quality of life. Secondary outcomes included biometric cardiometabolic risk factors (eg, body weight), self-reported diet and physical activity, mental health status, retention, session attendance, and participant satisfaction.
   Results: Change in quality of life was not significant in both immediate and delayed participants. Both groups significantly lost weight and reduced waist circumference at 6 months, with some cardiometabolic factors trending accordingly. Significant reduction in self-reported anxiety and perceived stress was seen in the immediate intervention group at 6 months. Retention rate was 93% at 3 months and 86% at 6 months post-baseline. Overall eCMP attendance was high with 59.5-83.8% of immediate and delayed intervention participants attending 50% of the virtual stress management and behavioral lifestyle sessions and 37.8-62.2% attending at least 4 out of 7 in-person physical activity sessions. The intervention received high ratings for satisfaction.
   Conclusions: The technology-assisted eCMP is a feasible and well-accepted intervention and may significantly decrease cardiometabolic risk among high-risk individuals.
C1 [Azar, Kristen M. J.] Sutter Hlth Res Dev & Disseminat, 2121 N Calif Blvd, Walnut Creek, CA 94596 USA.
   [Azar, Kristen M. J.; Xiao, Lan; Lv, Nan; Ma, Jun] Palo Alto Med Fdn, Res Inst, Palo Alto, CA 94301 USA.
   [Koliwad, Suneil] Univ Calif San Francisco, San Francisco, CA 94143 USA.
   [Poon, Tak; Griggs, Robert] Mills Peninsula Hosp, Burlingame, CA USA.
   [Ma, Jun] Stanford Univ, Sch Med, Palo Alto, CA 94304 USA.
   [Ma, Jun] Univ Illinois, Chicago, IL USA.
C3 Palo Alto Medical Foundation Research Institute; University of
   California System; University of California San Francisco; Stanford
   University; University of Illinois System; University of Illinois
   Chicago; University of Illinois Chicago Hospital
RP Azar, KMJ (corresponding author), Sutter Hlth Res Dev & Disseminat, 2121 N Calif Blvd, Walnut Creek, CA 94596 USA.
EM azark@sutterhealth.org
FU Palo Alto Medical Foundation
FX This was an investigator-initiated study funded by the Palo Alto Medical
   Foundation. No sponsor or funding source had a role in the design or
   conduct of the study; collection, management, analysis, or
   interpretation of the data; or preparation, review, or approval of the
   manuscript.
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NR 58
TC 31
Z9 32
U1 0
U2 8
PU JMIR PUBLICATIONS, INC
PI TORONTO
PA 130 QUEENS QUAY E, STE 1102, TORONTO, ON M5A 0P6, CANADA
SN 1438-8871
J9 J MED INTERNET RES
JI J. Med. Internet Res.
PD MAY
PY 2016
VL 18
IS 5
AR e134
DI 10.2196/jmir.5143
PG 13
WC Health Care Sciences & Services; Medical Informatics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services; Medical Informatics
GA FA9IL
UT WOS:000405759200001
PM 27234480
OA Green Submitted, gold, Green Published
DA 2025-06-11
ER

PT J
AU de Winter, CF
   Hermans, H
   Evenhuis, HM
   Echteld, MA
AF de Winter, C. F.
   Hermans, H.
   Evenhuis, H. M.
   Echteld, M. A.
TI Associations of symptoms of anxiety and depression with diabetes and
   cardiovascular risk factors in older people with intellectual disability
SO JOURNAL OF INTELLECTUAL DISABILITY RESEARCH
LA English
DT Article
DE ageing; anxiety; cardiovascular risk factors; depression; diabetes;
   intellectual disability; metabolic syndrome
ID METABOLIC SYNDROME; SYMPTOMATOLOGY IDS; HOSPITAL ANXIETY; DISORDERS;
   MOOD; OBESITY; ADULTS; SCALE; RELIABILITY; ADOLESCENTS
AB BackgroundDepression, anxiety, diabetes and cardiovascular risk factors are frequent health problems among older people with intellectual disability (ID). These conditions may be bidirectionally related. Depression and anxiety may have biological effects causing glucose intolerance, fat accumulation and also lifestyle changes causing metabolic syndrome. But also the effects of diabetes, metabolic syndrome and subsequent cardiovascular disease may affect mood and anxiety. This study investigated the association between depression, anxiety and diabetes and cardiovascular risk factors in older people with ID.
   MethodsThe healthy ageing in intellectual disability-study (HA-ID study) is a cross-sectional study among people aged 50 years and over with ID, receiving formal ID care. Screening instruments for symptoms of anxiety and depression were completed and physical examination and vena-puncture were performed to establish components of the metabolic syndrome, peripheral arterial disease and c-reactive protein.
   ResultsOf the 990 people who participated, 17% had symptoms of depression and 16% had symptoms of anxiety. Type I diabetes was present in 1%, type II diabetes in 13% of the study population. Metabolic syndrome, central obesity, hypercholesterolemia and hypertension were present in 45%, 48%, 23% and 53% respectively. In a multivariate logistic regression analysis a significant association was found between increased anxiety symptoms and diabetes only (OR 2.4, 95%CI 1.2-4.9).
   ConclusionsIncreased anxiety symptoms and diabetes are related in older people with ID. This association may be bidirectional. No other associations of depression and anxiety symptoms with cardiovascular risk factors could be proven to be significant. Therefore, more research is needed to unravel the mechanisms of stress, mood disorders and cardiovascular disease in older people with ID. To provide comprehensive care for older people with ID, screening for diabetes and components of the metabolic syndrome in people with anxiety or mood disorders, and screening for symptoms of anxiety or depression in people with diabetes is warranted.
C1 [de Winter, C. F.; Hermans, H.; Evenhuis, H. M.; Echteld, M. A.] Erasmus MC, Dept Gen Practice, Rotterdam, Netherlands.
   [de Winter, C. F.] Reinaerde, NL-3734 BP Den Dolder, Netherlands.
   [Hermans, H.] Amarant, Tilburg, Netherlands.
C3 Erasmus University Rotterdam; Erasmus MC
RP de Winter, CF (corresponding author), Reinaerde, Dolderseweg 170, NL-3734 BP Den Dolder, Netherlands.
EM channadewinter@hotmail.com
RI Echteld, Michael/IYJ-9188-2023
OI Echteld, Michael/0000-0001-8636-6342
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NR 44
TC 21
Z9 24
U1 0
U2 30
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0964-2633
EI 1365-2788
J9 J INTELL DISABIL RES
JI J. Intell. Disabil. Res.
PD FEB
PY 2015
VL 59
IS 2
SI SI
BP 176
EP 185
DI 10.1111/jir.12049
PG 10
WC Education, Special; Genetics & Heredity; Clinical Neurology; Psychiatry;
   Rehabilitation
WE Social Science Citation Index (SSCI)
SC Education & Educational Research; Genetics & Heredity; Neurosciences &
   Neurology; Psychiatry; Rehabilitation
GA AY8FG
UT WOS:000347789200009
PM 23627768
DA 2025-06-11
ER

PT J
AU Devaraj, S
   Valleggi, S
   Siegel, D
   Jialal, I
AF Devaraj, Sridevi
   Valleggi, Simona
   Siegel, David
   Jialal, Ishwarlal
TI Role of C-Reactive Protein in Contributing to Increased Cardiovascular
   Risk in Metabolic Syndrome
SO CURRENT ATHEROSCLEROSIS REPORTS
LA English
DT Article
DE CRP; Metabolic syndrome; Inflammation; Cardiovascular risk
ID CORONARY-HEART-DISEASE; ACTIVATOR INHIBITOR-1 EXPRESSION;
   INSULIN-RESISTANCE SYNDROME; AORTIC ENDOTHELIAL-CELLS; OXIDATIVE STRESS;
   MYOCARDIAL-INFARCTION; INFLAMMATORY MARKERS; BRACHIAL-ARTERY; KINASE
   PATHWAY; OXIDIZED LDL
AB Metabolic syndrome is associated with increased propensity for diabetes and cardiovascular disease. Low-grade inflammation is characteristic of metabolic syndrome. C-reactive protein, the best characterized biomarker of inflammation, is also an independent predictor of future cardiovascular events. This review outlines the role of high-sensitivity C-reactive protein in contributing to increased cardiovascular risk in metabolic syndrome by inducing endothelial cell dysfunction and activating monocytes.
C1 [Devaraj, Sridevi; Valleggi, Simona; Jialal, Ishwarlal] Univ Calif Davis, Med Ctr, Lab Atherosclerosis & Metab Res, Sacramento, CA 95817 USA.
   [Devaraj, Sridevi; Valleggi, Simona; Siegel, David; Jialal, Ishwarlal] Vet Affairs Med Ctr, Mather, CA USA.
C3 University of California System; University of California Davis; US
   Department of Veterans Affairs; Veterans Health Administration (VHA)
RP Jialal, I (corresponding author), Univ Calif Davis, Med Ctr, Lab Atherosclerosis & Metab Res, 4635 2nd Ave,Res 1 Bldg,Room 3000, Sacramento, CA 95817 USA.
EM ishwarlal.jialal@ucdmc.ucdavis.edu
RI Jialal, Ishwarlal/AAG-6218-2019
FU NIH [K24 AT 00596, HL 074360]
FX Grant Support from NIH K24 AT 00596, NIH HL 074360
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NR 90
TC 56
Z9 66
U1 0
U2 6
PU CURRENT MEDICINE GROUP
PI PHILADELPHIA
PA 400 MARKET STREET, STE 700, PHILADELPHIA, PA 19106 USA
SN 1523-3804
EI 1534-6242
J9 CURR ATHEROSCLER REP
JI Curr. Atheroscleros. Rep.
PD MAR
PY 2010
VL 12
IS 2
BP 110
EP 118
DI 10.1007/s11883-010-0098-3
PG 9
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 583DW
UT WOS:000276654300005
PM 20425246
OA Green Published, hybrid, Green Submitted
DA 2025-06-11
ER

PT J
AU Nishina, M
   Nishina, K
   Ohira, T
   Makino, K
   Iso, H
AF Nishina, Masahisa
   Nishina, Kazue
   Ohira, Tetsuya
   Makino, Kae
   Iso, Hiroyasu
TI Associations of Psychological Distress with Metabolic Syndrome Among
   Japanese Urban Residents
SO JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
LA English
DT Article
DE Cross-sectional studies; Depression; Metabolic syndrome; Psychological
   distress
ID CARDIOVASCULAR-DISEASE; DEPRESSIVE SYMPTOMS; HEART-DISEASE;
   YOUNG-ADULTS; RISK; ANXIETY; HEALTH; VARIABILITY; PREDICTORS; COMPONENTS
AB Aims: To examine and evaluate the association between psychological distress and metabolic syndrome (MetS).
   Methods: Between 2005 and 2006, 1,613 men and women aged 30-79 participated in annual health examinations at Takarazuka City Health Promotion Center in Takarazuka, Japan. Psychological stress was assessed with the General Health Questionnaire (GHQ) and MetS was evaluated using three criteria based on those of the Japanese Society of Internal Medicine as the Japanese counterpart of the third report of the National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Cholesterol in Adults (NCEP/ATP III) and the International Diabetes Federation (IDF).
   Results: The mean depression score after adjustment for age, smoking, alcohol intake and serum total cholesterol levels was higher for men with than without MetS as defined by Japanese criteria as well as for men with than without fasting glucose >= 110 mg/dL. Multivariable-adjusted, odds ratio associated with increments of one standard deviation in the depression score was 1.48 (1.19-1.84) for MetS, and anxiety and depression scores were 1.32 (1.08-1.61) and 1.24 (1.03-1.50) for fasting glucose >= 110 mg/dL, respectively. Similar trends were observed for the depression score and MetS as defined by NCEP/ATP. and IDF. For women, somatic symptoms, anxiety, and depression were not associated with MetS and its components.
   Conclusions: Depressive symptoms are considered to be associated with MetS and, more specifically, glucose abnormality among urban Japanese men.
C1 [Nishina, Masahisa; Ohira, Tetsuya; Iso, Hiroyasu] Osaka Univ, Grad Sch Med, Dept Social & Environm Med, Suita, Osaka 5650871, Japan.
   [Nishina, Kazue] Kazue Occupat Hlth Consultant Off, Osaka, Japan.
   [Makino, Kae] Takarazuka City Hlth Promot Ctr, Hyogo, Japan.
C3 The University of Osaka
RP Iso, H (corresponding author), Osaka Univ, Grad Sch Med, Dept Social & Environm Med, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan.
EM iso@pbhel.med.osaka-u.ac.jp
OI Iso, Hiroyasu/0000-0002-9241-7289
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NR 35
TC 28
Z9 30
U1 0
U2 9
PU JAPAN ATHEROSCLEROSIS SOC
PI TOKYO
PA NICHINAI-KAIKAN B1, 3-28-8 HONGO BUNKYO-KU, TOKYO, 113-0033, JAPAN
SN 1340-3478
EI 1880-3873
J9 J ATHEROSCLER THROMB
JI J. Atheroscler. Thromb.
PY 2011
VL 18
IS 5
BP 396
EP 402
DI 10.5551/jat.6692
PG 7
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Cardiovascular System & Cardiology
GA 770RJ
UT WOS:000291105900006
PM 21325777
OA hybrid
DA 2025-06-11
ER

PT J
AU Ashdown-Franks, G
   Firth, J
   Carney, R
   Carvalho, AF
   Hallgren, M
   Koyanagi, A
   Rosenbaum, S
   Schuch, FB
   Smith, L
   Solmi, M
   Vancampfort, D
   Stubbs, B
AF Ashdown-Franks, Garcia
   Firth, Joseph
   Carney, Rebekah
   Carvalho, Andre F.
   Hallgren, Mats
   Koyanagi, Ai
   Rosenbaum, Simon
   Schuch, Felipe B.
   Smith, Lee
   Solmi, Marco
   Vancampfort, Davy
   Stubbs, Brendon
TI Exercise as Medicine for Mental and Substance Use Disorders: A
   Meta-review of the Benefits for Neuropsychiatric and Cognitive Outcomes
SO SPORTS MEDICINE
LA English
DT Review
ID MAJOR DEPRESSIVE DISORDER; POSTTRAUMATIC-STRESS-DISORDER; NEUROTROPHIC
   FACTOR BDNF; PHYSICAL-ACTIVITY; BIPOLAR DISORDER; ANOREXIA-NERVOSA;
   AEROBIC EXERCISE; METHODOLOGICAL QUALITY; METABOLIC SYNDROME;
   DIABETES-MELLITUS
AB Background Exercise may improve neuropsychiatric and cognitive symptoms in people with mental disorders, but the totality of the evidence is unclear. We conducted a meta-review of exercise in (1) serious mental illness (schizophrenia spectrum, bipolar disorder and major depression (MDD)); (2) anxiety and stress disorders; (3) alcohol and substance use disorders; (4) eating disorders (anorexia nervosa bulimia nervosa, binge eating disorders, and (5) other mental disorders (including ADHD, pre/post-natal depression).
   Methods Systematic searches of major databases from inception until 1/10/2018 were undertaken to identify meta-analyses of randomised controlled trials (RCTs) of exercise in people with clinically diagnosed mental disorders. In the absence of available meta-analyses for a mental disorder, we identified systematic reviews of exercise interventions in people with elevated mental health symptoms that included non-RCTs. Meta-analysis quality was assessed with the AMSTAR/+.
   Results Overall, we identified 27 systematic reviews (including 16 meta-analyses representing 152 RCTs). Among those with MDD, we found consistent evidence (meta-analyses = 8) that exercise reduced depression in children, adults and older adults. Evidence also indicates that exercise was more effective than control conditions in reducing anxiety symptoms (meta-analyses = 3), and as an adjunctive treatment for reducing positive and negative symptoms of schizophrenia (meta-analyses = 2). Regarding neurocognitive effects, exercise improved global cognition in schizophrenia (meta-analyses = 1), children with ADHD (meta-analyses = 1), but not in MDD (meta-analyses = 1). Among those with elevated symptoms, positive mental health benefits were observed for exercise in people with pre/post-natal depression, anorexia nervosa/ bulimia nervosa, binge eating disorder, post-traumatic stress disorder and alcohol use disorders/substance use disorders. Adverse events were sparsely reported.
   Conclusion Our panoramic meta-overview suggests that exercise can be an effective adjunctive treatment for improving symptoms across a broad range of mental disorders.
C1 [Ashdown-Franks, Garcia; Stubbs, Brendon] South London & Maudsley NHS Fdn Trust, Denmark Hill, London SE5 8AZ, England.
   [Ashdown-Franks, Garcia; Stubbs, Brendon] Kings Coll London, Inst Psychiat Psychol & Neurosci IoPPN, Psychol Med, London, England.
   [Ashdown-Franks, Garcia; Stubbs, Brendon] Univ Toronto, Fac Kinesiol & Phys Educ, Toronto, ON, Canada.
   [Firth, Joseph] Western Sydney Univ, NICM Hlth Res Inst, Westmead, NSW, Australia.
   [Firth, Joseph] Univ Manchester, Div Psychol & Mental Hlth, Manchester, Lancs, England.
   [Firth, Joseph] Univ Melbourne, Ctr Youth Mental Hlth, Melbourne, Vic, Australia.
   [Carney, Rebekah] Greater Manchester Mental Hlth NHS Fdn Trust, Youth Mental Hlth Res Unit, Manchester, Lancs, England.
   [Carvalho, Andre F.] Univ Toronto, Dept Psychiat, Toronto, ON, Canada.
   [Carvalho, Andre F.] Ctr Addict & Mental Hlth CAMH, Toronto, ON, Canada.
   [Hallgren, Mats] Karolinska Inst, Dept Publ Hlth Sci, Unit Epidemiol Psychiat Condit Subst Use & Social, Stockholm, Sweden.
   [Koyanagi, Ai] Univ Barcelona, Parc Sanitari St Joan de Deu, Res & Dev Unit, Fundacio St Joan de Deu, Dr Antoni Pujadas 42, Barcelona 08830, Spain.
   [Rosenbaum, Simon] Sch Psychiat UNSW, Sydney, NSW, Australia.
   [Rosenbaum, Simon] Black Dog Inst, Sydney, NSW, Australia.
   [Schuch, Felipe B.] Univ Fed Santa Maria, Dept Methods & Sports Tech, Santa Maria, RS, Brazil.
   [Smith, Lee] Anglia Ruskin Univ, Cambridge Ctr Sport & Exercise Sci, Cambridge, England.
   [Solmi, Marco] Univ Padua, Neurosci Dept, Padua, Italy.
   [Vancampfort, Davy] Katholieke Univ Leuven, Dept Rehabil Sci, Louvain, Belgium.
   [Vancampfort, Davy] UPC KU Leuven, Leuven, Belgium.
C3 University of London; King's College London; University of Toronto;
   Western Sydney University; University of Manchester; Orygen, The
   National Centre of Excellence in Youth Mental Health; University of
   Melbourne; University of Toronto; University of Toronto; Centre for
   Addiction & Mental Health - Canada; Karolinska Institutet; University of
   Barcelona; Black Dog Institute; Universidade Federal de Santa Maria
   (UFSM); Anglia Ruskin University; University of Padua; KU Leuven; KU
   Leuven
RP Stubbs, B (corresponding author), South London & Maudsley NHS Fdn Trust, Denmark Hill, London SE5 8AZ, England.; Stubbs, B (corresponding author), Kings Coll London, Inst Psychiat Psychol & Neurosci IoPPN, Psychol Med, London, England.; Stubbs, B (corresponding author), Univ Toronto, Fac Kinesiol & Phys Educ, Toronto, ON, Canada.
EM brendon.stubbs@kcl.ac.uk
RI Firth, Joseph/JOZ-1679-2023; Rosenbaum, Simon/Y-3241-2019; Vancampfort,
   Davy/ABF-2439-2020; solmi, marco/K-3906-2018; Carvalho,
   Andre/AEZ-4001-2022; Smith, Lee/JPA-1418-2023; Stubbs,
   Brendon/X-1904-2018; Schuch, Felipe/AAF-5028-2019; Carney,
   Rebekah/AAO-5205-2021; Stubbs, Brendon/C-5696-2015; Schuch,
   Felipe/L-4620-2016
OI Smith, Lee/0000-0002-5340-9833; Ashdown-Franks,
   Garcia/0000-0002-5032-0171; Stubbs, Brendon/0000-0001-7387-3791; solmi,
   marco/0000-0003-4877-7233; Schuch, Felipe/0000-0002-5190-4515;
   Rosenbaum, Simon/0000-0002-8984-4941; Carney,
   Rebekah/0000-0002-2859-6825
FU Health Education England; NIHR Integrated Clinical Academic (ICA)
   Programme [ICA-CL-2017-03-001]; Maudsley Charity; National Institute for
   Health Research (NIHR) Collaboration for Leadership in Applied Health
   Research and Care South London at King's College Hospital NHS Foundation
   Trust; Blackmores Institute Fellowship; Research Capability Fund via
   Greater Manchester West Mental Health NHS Foundation Trust; Mitacs
   Globalink Research Award
FX Brendon Stubbs holds a Clinical Lectureship supported by Health
   Education England and the NIHR Integrated Clinical Academic (ICA)
   Programme (ICA-CL-2017-03-001). Brendon Stubbs is also part supported by
   the Maudsley Charity and the National Institute for Health Research
   (NIHR) Collaboration for Leadership in Applied Health Research and Care
   South London at King's College Hospital NHS Foundation Trust. The views
   expressed are those of the author[s] and not necessarily those of the
   NHS, the NIHR or the Department of Health and Social Care. John Firth is
   supported by a Blackmores Institute Fellowship. Rebekah Carney is funded
   by the Research Capability Fund via Greater Manchester West Mental
   Health NHS Foundation Trust. Garcia Ashdown-Franks is funded by a Mitacs
   Globalink Research Award.
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NR 124
TC 260
Z9 275
U1 38
U2 341
PU ADIS INT LTD
PI NORTHCOTE
PA 5 THE WAREHOUSE WAY, NORTHCOTE 0627, AUCKLAND, NEW ZEALAND
SN 0112-1642
EI 1179-2035
J9 SPORTS MED
JI Sports Med.
PD JAN
PY 2020
VL 50
IS 1
BP 151
EP 170
DI 10.1007/s40279-019-01187-6
PG 20
WC Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Sport Sciences
GA KH7QB
UT WOS:000510843600011
PM 31541410
OA Green Submitted
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Lee, YJ
   Hwang, SY
AF Lee, Yeo Jin
   Hwang, Seon Young
TI Influencing Factors for Cardiometabolic Risk in Korean Adolescents Based
   on 2010-2015 Data From the Korea National Health and Nutrition
   Examination Survey
SO JOURNAL OF CARDIOVASCULAR NURSING
LA English
DT Article
DE adolescents; cardiovascular disease; health behavior; metabolic
   syndrome; risk factors
ID METABOLIC-SYNDROME; PHYSICAL-ACTIVITY; CARDIOVASCULAR RISK; SEDENTARY
   BEHAVIOR; ADULTHOOD; CHILDREN
AB Background High academic stress and physical inactivity in Korean adolescents increase cardiometabolic risk factors, such as obesity, making it crucial to identify the factors influencing their risk. Objective Our aims were to determine differences in the prevalence of metabolic syndrome and its 5 components in Korean adolescents according to gender and to identify the influencing factors for cardiometabolic risk (individual risk factor >= 1). Methods Data related to adolescents from the Korean National Health and Nutrition Examination Survey (2010-2015) were assessed. Bivariate analyses to compare distribution and logistic regression analyses to examine the influencing factors were performed. Results Cardiometabolic risk (>= 1 risk factor) was found in 33.2% and 32.6% of male and female adolescents, respectively, and metabolic syndrome (>= 3 risk factors) was found in 2.0% and 2.3%, respectively. Among male adolescents, cardiometabolic risk was 1.66 times higher for the group that did not perform strength exercises (P = .007). For female adolescents, the cardiometabolic risk was 2.44 times higher in 16- to 18-year-olds than in 12- to 15-year-olds (P < .001) and 1.50 times higher in the non-aerobic-exercise group (P = .030). Central obesity (waist-to-height ratio >= 0.47) increased cardiometabolic risk by 5.71 and 13.91 times in male and female adolescents, respectively (P < .001). Conclusion To reduce cardiometabolic risk profiles and future cardiovascular risk in Korean adolescents, school-based physical activity programs should be actively provided not only for students with central obesity but also for students who lack aerobic or strength exercises.
C1 [Lee, Yeo Jin] Hanyang Univ, Grad Sch, Seoul, South Korea.
   [Hwang, Seon Young] Hanyang Univ, Sch Nursing, 222 Wangsimni Ro, Seoul 04763, South Korea.
C3 Hanyang University; Hanyang University
RP Hwang, SY (corresponding author), Hanyang Univ, Sch Nursing, 222 Wangsimni Ro, Seoul 04763, South Korea.
EM seon9772@hanyang.ac.kr
OI Hwang, Seon Young/0000-0003-3613-3350
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NR 31
TC 0
Z9 0
U1 0
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0889-4655
EI 1550-5049
J9 J CARDIOVASC NURS
JI J. Cardiovasc. Nurs.
PD SEP-OCT
PY 2022
VL 37
IS 5
BP 499
EP 508
DI 10.1097/JCN.0000000000000910
PG 10
WC Cardiac & Cardiovascular Systems; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Cardiovascular System & Cardiology; Nursing
GA 3R3LP
UT WOS:000838819000022
PM 35389916
DA 2025-06-11
ER

PT J
AU Ballegaard, S
   Petersen, PB
   Gyntelberg, F
   Faber, J
AF Ballegaard, Soren
   Petersen, Pernille B.
   Gyntelberg, Finn
   Faber, Jens
TI The association between pressure pain sensitivity, and answers to
   questionnaires estimating psychological stress level in the workplace A
   feasibility study
SO SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION
LA English
DT Article
DE Psychological stress; physiological stress; SF 36 questionnaire;
   Depression questionnaire; stress test; depression
ID CORONARY-ARTERY-DISEASE; INTEGRATED REHABILITATION; DIAGNOSTIC
   PERFORMANCE; METABOLIC SYNDROME; ALLOSTATIC LOAD; MENTAL STRESS; HEALTH;
   WORK; DEPRESSION; PREDICTION
AB Objectives. To examine the association between pressure pain sensitivity (PPS) at the sternum as a measure of persistent stress assessed by questionnaires in a working population. Methods. In 308 office employees PPS measurement was compared to Quality of life questionnaires: SF-36 for general physical and mental health, the Major Depression Inventory (MDI); 50 specific clinical symptoms for persistent stress; subjective evaluation of present and long-term stress level on a 7-point ordinal scale. Repeated measures were used to validate the PPS method. Results. A significant correlation between PPS and a persistent stress condition evaluated from SF-36, MDI and a number of clinical symptoms were found (all p < 0.01). Persons with PPS >= 60 units had an elevated health risk profile based on the questionnaires, when compared to persons with PPS <= 40 (all p < 0.05) (all odds ratios > 2). When categorizing a person with PPS >= 60 as persistently stressed (27% of subject), and using SF-36, MDI and the number of stress signs for risk calculation, the remaining 73% of the subjects, with no elevated health risk factors, were identified with an 80% specificity. During home measurements, with a full day between measurements, between-measurement correlation coefficient was 0.87 and categorization reproducibility 87% (both p < 0.001). Conclusions. In office workers, the PPS measurement correlated to several QOL questionnaires and was found useful for persistent stress screening. Validation studies demonstrated sufficient reproducibility including during self measurement at home.
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   [Gyntelberg, Finn] Natl Res Ctr Working Environm, Copenhagen, Denmark.
   [Faber, Jens] Herlev Univ Hosp, Dept Med O, Endocrine Unit, DK-2730 Herlev, Denmark.
   [Faber, Jens] Univ Copenhagen, Fac Hlth Sci, Copenhagen, Denmark.
C3 National Research Centre for the Working Environment; University of
   Copenhagen; Herlev & Gentofte Hospital; University of Copenhagen
RP Ballegaard, S (corresponding author), Ull Care, Lemchesvej 1, DK-2900 Hellerup, Denmark.
EM sba@ullcare.com
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NR 41
TC 15
Z9 16
U1 0
U2 12
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0036-5513
EI 1502-7686
J9 SCAND J CLIN LAB INV
JI Scand. J. Clin. Lab. Invest.
PD OCT
PY 2012
VL 72
IS 6
BP 459
EP 466
DI 10.3109/00365513.2012.695023
PG 8
WC Medical Laboratory Technology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Medical Laboratory Technology; Research & Experimental Medicine
GA 008EY
UT WOS:000308941400004
PM 22974296
DA 2025-06-11
ER

PT J
AU Basiri, R
   Seidu, B
   Cheskin, LJ
AF Basiri, Raedeh
   Seidu, Blessing
   Cheskin, Lawrence J.
TI Key Nutrients for Optimal Blood Glucose Control and Mental Health in
   Individuals with Diabetes: A Review of the Evidence
SO NUTRIENTS
LA English
DT Review
DE diabetes; mental health; anxiety; depression; supplementation;
   nutrients; blood glucose; nutrition; omega-3 fatty acids; vitamin D;
   vitamin E; vitamin B6; vitamin B12; folate; selenium; chromium; iron;
   magnesium
ID VITAMIN-E; INSULIN-RESISTANCE; OXIDATIVE STRESS; 1,25-DIHYDROXYVITAMIN
   D-3; CHROMIUM SUPPLEMENTATION; DOCOSAHEXAENOIC ACID; DEPRESSIVE
   DISORDER; METABOLIC SYNDROME; GLYCEMIC CONTROL; GUT MICROBIOTA
AB Diabetes is associated with an increased risk of mental disorders, including depression, anxiety, and cognitive decline. Mental disorders can also contribute to the development of diabetes through various mechanisms including increased stress, poor self-care behaviors, and adverse effects on glucose metabolism. Consequently, individuals suffering from either of these conditions frequently experience comorbidity with the other. Nutrition plays an important role in both diabetes and mental health disorders including depression and anxiety. Deficiencies in specific nutrients such as omega-3 fatty acids, vitamin D, B vitamins, zinc, chromium, magnesium, and selenium have been implicated in the pathogenesis of both diabetes and mental disorders. While the impact of nutrition on the progression and control of diabetes and mental disorders is broadly acknowledged, there is a notable knowledge gap concerning the implications of distinct nutrients in preventing and mitigating symptoms of both conditions when they coexist. The aim of this study was to examine the role of nutrition in improving glucose homeostasis and promoting mental well-being among individuals with diabetes. Further, we evaluated the preventive or delaying effects of key nutrients on the simultaneous manifestation of these conditions when one of them is present. Our findings indicated that the use of personalized dietary interventions and targeted nutrient supplementation can improve metabolic and mental health outcomes in patients with type 2 diabetes.
C1 [Basiri, Raedeh; Seidu, Blessing; Cheskin, Lawrence J.] George Mason Univ, Dept Nutr & Food Studies, Fairfax, VA 22030 USA.
   [Basiri, Raedeh; Cheskin, Lawrence J.] George Mason Univ, Inst Biohlth Innovat, Fairfax, VA 22030 USA.
   [Cheskin, Lawrence J.] Johns Hopkins Sch Med, Dept Med, Baltimore, MD 21205 USA.
C3 George Mason University; George Mason University; Johns Hopkins
   University; Johns Hopkins Medicine
RP Basiri, R (corresponding author), George Mason Univ, Dept Nutr & Food Studies, Fairfax, VA 22030 USA.; Basiri, R (corresponding author), George Mason Univ, Inst Biohlth Innovat, Fairfax, VA 22030 USA.
EM rbasiri@gmu.edu
RI Cheskin, Lawrence/AAM-1094-2021
OI Seidu, Blessing/0009-0001-5757-6006; Basiri, Raedeh/0000-0002-7780-3771
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NR 187
TC 6
Z9 7
U1 3
U2 13
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD SEP
PY 2023
VL 15
IS 18
AR 3929
DI 10.3390/nu15183929
PG 16
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA AN9G8
UT WOS:001119257500001
PM 37764713
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Anand, S
   Kumar, P
   Singh, S
   Tiwari, S
   Mishra, R
   Uguz, S
   Saud, S
   Mor, SK
   Yang, XF
   Mcclements, DJ
AF Anand, Sakshi
   Kumar, Pradeep
   Singh, Sevaram
   Tiwari, Shalini
   Mishra, Ranjana
   Uguz, Seyit
   Saud, Shah
   Mor, Sunil Kumar
   Yang, Xufei
   Mcclements, David Julian
TI Diet-Gut Microbiome Nexus: A New Paradigm in Food-Based Mental Disease
   Therapeutics
SO FOOD REVIEWS INTERNATIONAL
LA English
DT Review; Early Access
DE Depression; gut; gut-brain axis; microbiome; metabolic syndrome;
   nutrients
ID ANXIETY-LIKE BEHAVIOR; INTESTINAL MICROBIOTA; BRAIN AXIS; TEMPORAL
   DEVELOPMENT; PARKINSONS-DISEASE; COLONIC MICROBIOME; HEALTH; STRESS;
   DEPRESSION; CHILDREN
AB Mental health and well-being are greatly influenced by interactions between gut microbiota and the brain. This "gut microbiome-brain axis" (GMBA) operates through the various metabolic products released by gut microbes, which can be altered by diet changes. Additional research is needed to elucidate the association among diet, microbial constitution, metabolite production, and various neurological and neurodegenerative conditions. This article abridges the current understanding of microbiota-mediated mental pathogenesis, opportunities for non-invasive diagnosis, and treatment options utilizing GMBA modulations. Research on the interactions between diet, microbiota, and the brain has revealed that nutritional therapy could be a promising approach for preventing or treating depression, anxiety, and neurodegenerative diseases. Studies show that the gut microbiota regulates neurological pathways, endocrine signaling, tryptophan metabolism, gut-brain communication, and immune responses. The consumption of dietary components like prebiotics, probiotics, and pharmaceutical products can modify the gut microbiota, influencing mental health and well-being. Moreover, both psychiatric and non-psychiatric neurodegenerative disorders, as well as bacterial infections, play a critical role in maintaining gut microbiota and affecting mental health. As a result, there is potential to develop innovative functional foods, supplements, or medicines tailored to support a gut microbiome that promotes better mental health.
C1 [Anand, Sakshi] Jaypee Inst Informat Technol, Dept Biotechnol, Noida, India.
   [Kumar, Pradeep; Tiwari, Shalini; Uguz, Seyit; Yang, Xufei] South Dakota State Univ, Dept Agr & Biosyst Engn, Raven Precis Ag Bldg 224,Ag & Biosyst Engn Box 210, Brookings, SD 57007 USA.
   [Singh, Sevaram; Mishra, Ranjana] Translat Hlth Sci & Technol Inst, NCR Biotech Sci Cluster, Faridabad, India.
   [Singh, Sevaram; Mishra, Ranjana] Jawaharlal Nehru Univ, New Delhi, India.
   [Uguz, Seyit] Bursa Uludag Univ, Fac Agr, Biosyst Engn, Bursa, Turkiye.
   [Saud, Shah] Linyi Univ, Coll Life Sci, Linyi, Shandong, Peoples R China.
   [Mor, Sunil Kumar] South Dakota State Univ, Dept Vet & Biomed Sci, Anim Dis Res & Diagnost Lab, Brookings, SD USA.
   [Mcclements, David Julian] Univ Massachusetts, Dept Food Sci, Amherst, MA USA.
C3 Jaypee Institute of Information Technology (JIIT); South Dakota State
   University; Department of Biotechnology (DBT) India; Translational
   Health Science & Technology Institute (THSTI); Jawaharlal Nehru
   University, New Delhi; Uludag University; Linyi University; South Dakota
   State University; University of Massachusetts System; University of
   Massachusetts Amherst
RP Kumar, P (corresponding author), South Dakota State Univ, Dept Agr & Biosyst Engn, Raven Precis Ag Bldg 224,Ag & Biosyst Engn Box 210, Brookings, SD 57007 USA.
EM pradeeps416@gmail.com
RI Kumar, Pradeep/ABA-6989-2021; Mor, Sunil/M-6325-2018; McClements,
   David/JBR-7908-2023; UĞUZ, SEYİT/ABH-7275-2020; Yang, Xufei/N-3317-2013;
   Saud, Shah/LPQ-9115-2024
OI Kumar, Pradeep/0000-0001-7245-8211; Saud, Shah/0000-0002-3761-2858
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NR 170
TC 0
Z9 0
U1 4
U2 4
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 8755-9129
EI 1525-6103
J9 FOOD REV INT
JI Food Rev. Int.
PD 2025 MAR 21
PY 2025
DI 10.1080/87559129.2025.2479123
EA MAR 2025
PG 27
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA 0JT4A
UT WOS:001449030600001
DA 2025-06-11
ER

PT J
AU Hu, MX
   Lamers, F
   Hiles, SA
   Penninx, BWJH
   de Geus, EJC
AF Hu, Mandy X.
   Lamers, Femke
   Hiles, Sarah A.
   Penninx, Brenda W. J. H.
   de Geus, Eco J. C.
TI Basal autonomic activity, stress reactivity, and increases in metabolic
   syndrome components over time
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE Autonomic nervous system; Metabolic syndrome; Stress; Cardiovascular
   disease
ID HEART-RATE-VARIABILITY; MAJOR DEPRESSIVE DISORDER; FUTURE
   BLOOD-PRESSURE; RESPIRATORY SINUS ARRHYTHMIA;
   SYMPATHETIC-NERVOUS-SYSTEM; ACUTE PSYCHOLOGICAL STRESS; CARDIOVASCULAR
   REACTIVITY; AMBULATORY MEASUREMENT; FOLLOW-UP; PREDICTS
AB Context: Basal autonomic nervous system (ANS) functioning has been linked to the metabolic syndrome (MetS), but the role of ANS reactivity in response to stress remains unclear.
   Objective: To examine cross-sectionally and longitudinally to what extent ANS basal level and stress reactivity are related to MetS.
   Design: 2-year and 6-year data from a prospective cohort: the Netherlands Study of Depression and Anxiety.
   Setting: Participants were recruited from the general community, primary care, and mental health care organizations.
   Participants: 1922 respondents (mean age = 43.7 years).
   Main outcome measures: Indicators of ANS functioning were heart rate (HR), respiratory sinus arrhythmia (RSA) and pre-ejection period (PEP). ANS stress reactivity was measured during a cognitively challenging stressor and a personal-emotional stressor. MetS components included triglycerides, high-density lipoprotein cholesterol, blood pressure, glucose and waist circumference.
   Results: Cross-sectional analyses indicated that higher basal HR, lower basal values of RSA and PEP, and higher RSA reactivity during cognitive challenge were related to less favorable values of almost all individual MetS components. Longitudinal analyses showed that higher basal HR and shorter basal PEP predicted 4-year increase in many MetS abnormalities. Higher RSA stress reactivity during cognitive challenge predicted 4-year increase in number of MetS components.
   Conclusion: Higher basal sympathetic, lower basal parasympathetic activity, and increased parasympathetic withdrawal during stress are associated with multiple MetS components, and higher basal sympathetic activity predicts an increase in metabolic abnormalities over time. These findings support a role for ANS dysregulation in the risk for MetS and, consequently, the development of cardiovascular disease. (C) 2016 Elsevier Ltd. All rights reserved.
C1 [Hu, Mandy X.; Lamers, Femke; Hiles, Sarah A.; Penninx, Brenda W. J. H.] Vrije Univ Amsterdam Med Ctr, Dept Psychiat, AJ Ernststr 1187, NL-1081 HL Amsterdam, Netherlands.
   [Hu, Mandy X.; Lamers, Femke; Hiles, Sarah A.; Penninx, Brenda W. J. H.] Vrije Univ Amsterdam Med Ctr, EMGO Inst Hlth & Care Res, AJ Ernststr 1187, NL-1081 HL Amsterdam, Netherlands.
   [de Geus, Eco J. C.] Vrije Univ Amsterdam, Dept Biol Psychol, Boechorststr 1, NL-1081 BT Amsterdam, Netherlands.
   [de Geus, Eco J. C.] Vrije Univ Amsterdam, EMGO Inst Hlth & Care Res, Boechorststr 1, NL-1081 BT Amsterdam, Netherlands.
C3 Vrije Universiteit Amsterdam; VU UNIVERSITY MEDICAL CENTER; Vrije
   Universiteit Amsterdam; VU UNIVERSITY MEDICAL CENTER; Vrije Universiteit
   Amsterdam; Vrije Universiteit Amsterdam
RP Hu, MX (corresponding author), Vrije Univ Amsterdam Med Ctr, Dept Psychiat, AJ Ernststr 1187, NL-1081 HL Amsterdam, Netherlands.
EM m.hu@ggzingeest.nl
RI Penninx, Brenda/S-7627-2017; Lamers, Femke/G-5161-2012; Hiles,
   Sarah/AAE-3430-2019; de Geus, Eco/M-9318-2015
OI Lamers, Femke/0000-0003-4344-5766; de Geus, Eco/0000-0001-6022-2666; Hu,
   Mandy Xian/0000-0002-4496-8772; Hiles, Sarah/0000-0002-2723-2798
FU Geestkracht program of the Netherlands Organisation for Health Research
   and Development (Zon-Mw) [10-000-1002]; VU University Medical Center;
   Leiden University Medical Center; University Medical Center Groningen;
   European Union Seventh Framework Programme (FP7)
   [PCIG12-GA-2012-334065]; European Union's Horizon research and
   innovation programme under the Marie Sklodowska-Curie grant [658897];
   Marie Curie Actions (MSCA) [658897] Funding Source: Marie Curie Actions
   (MSCA)
FX The infrastructure for the NESDA study (www.nesda.nl) has been funded
   through the Geestkracht program of the Netherlands Organisation for
   Health Research and Development (Zon-Mw, grant number 10-000-1002) and
   participating universities (VU University Medical Center, Leiden
   University Medical Center, University Medical Center Groningen).FL has
   received funding from the European Union Seventh Framework Programme
   (FP7/2007-2013) under grant agreement no PCIG12-GA-2012-334065. SAH
   received funding from the European Union's Horizon 2020 research and
   innovation programme under the Marie Sklodowska-Curie grant agreement
   No. 658897.
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NR 64
TC 14
Z9 17
U1 0
U2 17
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD SEP
PY 2016
VL 71
BP 119
EP 126
DI 10.1016/j.psyneuen.2016.05.018
PG 8
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA DT0GY
UT WOS:000381163000015
PM 27262344
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Sharma, M
   Gaidhane, A
   Choudhari, SG
AF Sharma, Mayank
   Gaidhane, Abhay
   Choudhari, Sonali G.
TI Assessing Cardiometabolic Disease Risk Factors Among Healthcare Workers
   in a Rural Tertiary Care Hospital in Wardha, India: A Study Protocol
SO CUREUS JOURNAL OF MEDICAL SCIENCE
LA English
DT Article
DE india; cross-sectional study; risk factors; rural setting; healthcare
   workers; cardio-metabolic diseases
ID PREVALENCE
AB Background Cardiometabolic diseases pose a significant public health challenge globally, particularly among healthcare workers, who often face heightened occupational stress and lifestyle challenges. This study aims to assess the prevalence of cardiometabolic risk factors and their determinants among healthcare workers at Acharya Vinoba Bhave Rural Hospital, a tertiary care hospital in rural Wardha, Maharashtra, India. Methods A cross-sectional study design was employed, involving the recruitment of healthcare workers from various job roles. Data on demographic characteristics, behavioral risk factors, anthropometric measurements, biochemical parameters, and mental health status was collected using standardized instruments and procedures. Statistical analysis included descriptive statistics, inferential tests, and multivariate analyses to identify significant associations and predictors of cardiometabolic risk factors. Expected results Anticipated findings include a notable prevalence of cardiometabolic risk factors among healthcare workers, including elevated BMI, fasting blood glucose, dyslipidemia, and hypertension. Behavioral risk factors such as physical inactivity, unhealthy dietary habits, tobacco use, and alcohol consumption are expected to be prevalent. Additionally, varying degrees of psychological distress, including depression, anxiety, and stress, are anticipated. Significant associations between cardiometabolic risk factors and demographic variables are expected to be identified. Conclusion The study findings provide valuable insights into the prevalence and determinants of cardiometabolic risk factors among healthcare workers in a rural setting. These insights can inform targeted interventions and public health strategies aimed at improving the cardiovascular health and overall well-being of healthcare workers, ultimately contributing to the enhancement of healthcare delivery and outcomes in rural areas.
C1 [Sharma, Mayank; Gaidhane, Abhay; Choudhari, Sonali G.] Datta Meghe Inst Higher Educ & Res, Jawaharlal Nehru Med Coll, Community Med, Wardha, India.
C3 Datta Meghe Institute of Higher Education & Research (Deemed to be
   University); Jawaharlal Nehru Medical College Wardha
RP Sharma, M (corresponding author), Datta Meghe Inst Higher Educ & Res, Jawaharlal Nehru Med Coll, Community Med, Wardha, India.
EM drmayanksharma1@gmail.com
RI Gaidhane, Abhay/AAK-7144-2020; Choudhari, Dr. Sonali Choudhari
   MD/AAE-7904-2019; Sharma, Dr Mayank/JQV-7842-2023
OI , Mayank Sharma/0009-0000-5904-8867
FX Acknowledgements Critical review of the manuscript for important
   intellectual content: Mayank Sharma, Sonali G. Choudhari, Abhay Gaidhane
   Supervision: Abhay Gaidhane Disclosures Human subjects: Consent was
   obtained or waived by all participants in this study. Institutional
   Ethics Committee, Datta Meghe Institute of Higher Education & Research
   issued approval DMIHER (DU) /IEC/2024/138. Animal subjects: All authors
   have confirmed that this study did not involve animal subjects or
   tissue. Conflicts of interest: In compliance with the ICMJE uniform
   disclosure form, all authors declare the following: Payment/services
   info: All authors have declared that no financial support was received
   from any organization for the submitted work. Financial relationships:
   All authors have declared that they have no financial relationships at
   present or within the previous three years with any organizations that
   might have an interest in the submitted work. Other relationships: All
   authors have declared that there are no other relationships or
   activities that could appear to have influenced the submitted work.
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NR 15
TC 0
Z9 0
U1 0
U2 0
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
EI 2168-8184
J9 CUREUS J MED SCIENCE
JI Cureus J Med Sci
PD JUN 27
PY 2024
VL 16
IS 6
AR e63261
DI 10.7759/cureus.63261
PG 5
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA XY3G3
UT WOS:001265195000031
PM 39070525
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Park, EJ
   Kim, SY
   Kim, Y
   Sung, D
   Kim, B
   Hyun, Y
   Jung, KI
   Lee, SY
   Kim, H
   Park, S
   Kim, BN
   Park, MH
AF Park, E-Jin
   Kim, Shin-Young
   Kim, Yeeun
   Sung, Dajung
   Kim, Bora
   Hyun, Yerin
   Jung, Kyu-In
   Lee, Seung-Yup
   Kim, Hayeon
   Park, Subin
   Kim, Bung-Nyun
   Park, Min-Hyeon
TI The Relationship between Adverse Childhood Experiences and Sleep
   Problems among Adolescent Students: Mediation by Depression or Anxiety
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Article
DE threatening experiences; trauma; insomnia; physical health; mental
   health; interventions
ID POSTTRAUMATIC-STRESS-DISORDER; POTENTIALLY TRAUMATIC EVENTS; METABOLIC
   SYNDROME; PSYCHOMETRIC PROPERTIES; HOUSEHOLD DYSFUNCTION; CHILDRENS
   DEPRESSION; DAYTIME SLEEPINESS; INSOMNIA SEVERITY; LIFE EVENTS; ABUSE
AB Adverse childhood experiences (ACEs) are known to be closely related to depression, anxiety and sleep problems. However, it remains unclear whether adolescents with ACEs have sleep problems regardless of depression or anxiety or under a mediating effect from depression or anxiety. Therefore, our aim was to examine whether depression or anxiety mediates the relationship between ACEs and sleep problems in adolescents by using a community sample. The Early Trauma Inventory Self Report-Short Form (ETISR-SF) and List of Threatening Experiences Questionnaire (LTE-Q) were used to assess traumatic ACEs. Ultimately, data from 737 students (M = 448, F = 289, 15.1 +/- 1.4 years old) were included in the statistical analysis. A total of 576 (78.1%) participants reported that they had experienced one or more ACEs. Adolescents with ACEs had higher levels of depression, anxiety and sleep problems than did adolescents without ACEs, and boys tended to experience more trauma than girls. Depression and anxiety partially mediated the relationship between ACEs and sleep problems. The results of this study suggest the need for depression and anxiety interventions for adolescents with ACEs to reduce the long-term consequences, including sleep problems and physical health problems.
C1 [Park, E-Jin] Catholic Univ Korea, Coll Med, Incheon St Marys Hosp, Dept Psychiat, Incheon 400011, South Korea.
   [Kim, Shin-Young; Kim, Yeeun; Sung, Dajung; Kim, Bora; Hyun, Yerin; Jung, Kyu-In; Lee, Seung-Yup; Kim, Hayeon; Park, Min-Hyeon] Catholic Univ Korea, Coll Med, Eunpyeong St Marys Hosp, Dept Psychiat, Seoul 06591, South Korea.
   [Park, Subin] Natl Ctr Mental Hlth, Dept Res Planning, Seoul 04933, South Korea.
   [Kim, Bung-Nyun] Seoul Natl Univ, Dept Psychiat & Behav Sci, Coll Med, Seoul 08826, South Korea.
C3 Catholic University of Korea; Catholic University of Korea; Seoul
   National University (SNU)
RP Park, MH (corresponding author), Catholic Univ Korea, Coll Med, Eunpyeong St Marys Hosp, Dept Psychiat, Seoul 06591, South Korea.
EM zahir@catholic.ac.kr; helenasykim@gmail.com; catholic1120@gmail.com;
   jenndj28@gmail.com; chiroo3333@naver.com; rin9211@naver.com;
   cki@catholic.ac.kr; solero82@gmail.com; hayoning@gmail.com;
   subin-21@hanmail.net; kbn1@snu.ac.kr; neominnie00@daum.net
RI Kim, Hogene/AAM-2372-2021; Kim, Byung-Hak/AAY-9891-2020
OI SUNG, DAJUNG/0000-0002-6631-8762; Park, Subin/0000-0002-4623-9899; KIM,
   BORA/0000-0003-2827-6888; Lee, Seung-Yup/0000-0001-5635-8958
FU National Research Foundation of Korea (NRF) - Korean Government
   [NRF-2014R1A1A2057866]; Catholic Medical Center Research Foundation
FX This research was supported by a National Research Foundation of Korea
   (NRF) grant funded by the Korean Government (NRF-2014R1A1A2057866) and
   by the Catholic Medical Center Research Foundation during program year
   2019.
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NR 61
TC 36
Z9 44
U1 3
U2 50
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD JAN
PY 2021
VL 18
IS 1
AR 236
DI 10.3390/ijerph18010236
PG 15
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA PP7YK
UT WOS:000606073400001
PM 33396920
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Blessing, EM
   Reus, V
   Mellon, SH
   Wolkowitz, OM
   Flory, JD
   Bierer, L
   Lindqvist, D
   Dhabhar, F
   Li, M
   Qian, M
   Abu-Amara, D
   Galatzer-Levy, I
   Yehuda, R
   Marmar, CR
AF Blessing, Esther M.
   Reus, Victor
   Mellon, Synthia H.
   Wolkowitz, Owen M.
   Flory, Janine D.
   Bierer, Linda
   Lindqvist, Daniel
   Dhabhar, Firdaus
   Li, Meng
   Qian, Meng
   Abu-Amara, Duna
   Galatzer-Levy, Isaac
   Yehuda, Rachel
   Marmar, Charles R.
TI Biological predictors of insulin resistance associated with
   posttraumatic stress disorder in young military veterans
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE PTSD; Insulin resistance; Prediabetes; Sympathetic; Inflammation; Brain
   derived neurotrophic factor
ID HOMEOSTASIS MODEL ASSESSMENT; MAJOR DEPRESSIVE DISORDER; MENTAL-HEALTH
   DIAGNOSES; CORONARY-HEART-DISEASE; METABOLIC SYNDROME; RISK-FACTORS;
   NEUROTROPHIC FACTOR; OPTIMAL CUTOFF; PTSD; PREVALENCE
AB Posttraumatic stress disorder (PTSD) is associated with increased risk for Type 2 diabetes and cardiovascular disease (cardiometabolic disease), warranting research into targeted prevention strategies. In the present case control study of 160 young (mean age 32.7 years) male military veterans, we aimed to assess whether PTSD status predicted increased markers of cardiometabolic risk in otherwise healthy individuals, and further, to explore biological pathways between PTSD and these increased markers of cardiometabolic risk. Toward these aims, we compared measures of cardiometabolic risk, namely insulin resistance alo (HOMA-IR), metabolic syndrome (MetS) and prediabetes, between 80 PTSD cases and 80 controls without PTSD. We then determined whether PTSD-associated increases in HOMA-IR were correlated with select biological variables from pathways previously hypothesized to link PTSD with cardiometabolic risk, including systemic inflammation (increased C-reactive protein, interleukin-6, and tumor necrosis factor a), sympathetic over-activity (increased resting heart rate), and neuroendocrine dysregulation (increased plasma cortisol or serum brain-derived neurotrophic factor (BDNF)). We found PTSD diagnosis was associated with substantially higher HOMA-IR (cases 4.3. +/- 4.3 vs controls 2.4 +/- 2.0; p < 0.001), and a higher frequency of MetS (cases 21.3% vs controls 2.5%; p < 0.001), but not prediabetes (cases 20.0% vs controls 18.8%; p > 0.05). Cases also had increased pro-inflammatory cytokines (p < 0.01), heart rate (p < 0.001), and BDNF (p < 0.001), which together predicted increased HOIVIA-IR (adjusted R-2 = 0.68, p < 0.001). Results show PTSD diagnosis in young male military veterans without cardiometabolic disease is associated with increased IR, predicted by biological alterations previously hypothesized to link PTSD to increased cardiometabolic risk. Findings support further research into early, targeted prevention of cardiometabolic disease in individuals with PTSD.
C1 [Blessing, Esther M.; Li, Meng; Qian, Meng; Abu-Amara, Duna; Galatzer-Levy, Isaac; Marmar, Charles R.] NYU, Langone Med Ctr, Steven & Alexandra Cohen Vet Ctr Posttraumat Stre, Dept Psychiat, New York, NY 10003 USA.
   [Reus, Victor; Mellon, Synthia H.; Wolkowitz, Owen M.; Lindqvist, Daniel] Univ Calif San Francisco, Sch Med, Dept Psychiat, San Francisco, CA USA.
   [Mellon, Synthia H.] Univ Calif San Francisco, Sch Med, Dept OB GYN & Reprod Sci, San Francisco, CA USA.
   [Flory, Janine D.; Bierer, Linda; Yehuda, Rachel] Icahn Sch Med Mt Sinai, James J Peters Vet Affairs Med Ctr, Dept Psychiat, New York, NY 10029 USA.
   [Lindqvist, Daniel] Lund Univ, Dept Clin Sci, Fac Med, Psychiat, Lund, Sweden.
   [Lindqvist, Daniel] Univ Miami, Sylvester Comprehens Canc Ctr, Dept Psychiat & Behav Sci, Coral Gables, FL 33124 USA.
C3 New York University; NYU Langone Medical Center; University of
   California System; University of California San Francisco; University of
   California System; University of California San Francisco; Icahn School
   of Medicine at Mount Sinai; Lund University; University of Miami
RP Blessing, EM (corresponding author), NYU, Langone Med Ctr, Steven & Alexandra Cohen Vet Ctr Posttraumat Stre, Dept Psychiat, New York, NY 10003 USA.
EM esther.blessing@nyumc.org
RI Marmar, Charles/O-1902-2017; reus, victor/I-7923-2015; Qian,
   Meng/L-3244-2013; Wolkowitz, Owen/J-6649-2013
OI Galatzer-Levy, Isaac/0000-0003-1864-064X
FU U. S. Department of Defense [W81XWH-11-2-0223, W81XWH-10-1-0021]; Mental
   Illness Research, Education and Clinical Center (MIRECC); Swedish
   Research Council [2015-00387]; Marie Sklodowska Curie Actions, Cofund
   [INCA 600398]; Swedish Society of Medicine; Soderstrom-Konigska
   Foundation; Sjobring Foundation; OM Persson Foundation; province of
   Scania (Sweden) state grants CALF)
FX This study was supported by the following grants: U. S. Department of
   Defense, W81XWH-11-2-0223 (PI: Charles Marmar); U. S. Department of
   Defense, W81XWH-10-1-0021 (PI: Owen M. Wolkowitz); The Mental Illness
   Research, Education and Clinical Center (MIRECC). Daniel Lindqvist was
   supported by the Swedish Research Council (2015-00387), Marie Sklodowska
   Curie Actions, Cofund (Project INCA 600398), the Swedish Society of
   Medicine, the Soderstrom-Konigska Foundation, the Sjobring Foundation,
   OM Persson Foundation and the province of Scania (Sweden) state grants
   CALF). We thank Dr. Carole Siegel and Dr. Eugene Laska for helpful
   discussions.
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NR 52
TC 46
Z9 50
U1 0
U2 11
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
EI 1873-3360
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD AUG
PY 2017
VL 82
BP 91
EP 97
DI 10.1016/j.psyneuen.2017.04.016
PG 7
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA FA2EX
UT WOS:000405254700012
PM 28521179
DA 2025-06-11
ER

PT J
AU Wiltink, J
   Michal, M
   Jünger, C
   Münzel, T
   Wild, PS
   Lackner, KJ
   Blettner, M
   Pfeiffer, N
   Brähler, E
   Beutel, ME
AF Wiltink, Joerg
   Michal, Matthias
   Juenger, Claus
   Muenzel, Thomas
   Wild, Philipp S.
   Lackner, Karl J.
   Blettner, Maria
   Pfeiffer, Norbert
   Braehler, Elmar
   Beutel, Manfred E.
TI Associations between degree and sub-dimensions of depression and
   metabolic syndrome (MetS) in the community: results from the Gutenberg
   Health Study (GHS)
SO BMC PSYCHIATRY
LA English
DT Article
DE Metabolic syndrome; Depression; Comorbidity; Somatic; Mental health care
ID PRIMARY-CARE; MAJOR DEPRESSION; BLOOD-PRESSURE; HEART-RATE; ANXIETY;
   SYMPTOMS; PREVALENCE; DISORDER; RISK; QUESTIONNAIRE-9
AB Background: A growing number of studies have associated metabolic syndrome (MetS) and depression, both retrospectively and prospectively. However, it has remained unclear, which degrees, or sub-dimensions of depression are related to MetS and if comorbid depression affects health care utilization. The purpose of the study was to determine the associations of a) somatic and cognitive-affective symptoms to MetS and b) depression and MetS to health care utilization.
   Methods: In a population-based, representative survey of 14.499 participants we studied the associations of the two dimensions of depression with MetS and health care utilization. Depressive symptoms were assessed by the Patient Health Questionnaire (PHQ-9).
   Results: MetS and its components were associated with the degree of depression, particularly with moderately severe/severe depressive symptoms (PHQ-9 > = 15). There were clear positive associations of somatic-affective depressive symptoms with the presence of MetS and its components. Cognitive-affective symptoms were negatively associated with MetS. At the single item level, disorders of sleep and appetite as well as exhaustion were positively, while trouble concentrating was negatively associated with MetS. Symptoms of depression were related to higher consultations of somatic and mental health care, while the presence of MetS was related to somatic health care utilization. There was an additional interaction of depressive symptoms and MetS with mental health care.
   Conclusions: Somatic affective symptoms of depression are positively associated, while cognitive-affective symptoms are negatively associated with MetS.
C1 [Wiltink, Joerg; Michal, Matthias; Braehler, Elmar; Beutel, Manfred E.] Johannes Gutenberg Univ Mainz, Univ Med Ctr, Dept Psychosomat Med & Psychotherapy, Mainz, Germany.
   [Juenger, Claus; Muenzel, Thomas] Johannes Gutenberg Univ Mainz, Univ Med Ctr, Ctr Cardiol, Mainz, Germany.
   [Wild, Philipp S.] Johannes Gutenberg Univ Mainz, Univ Med Ctr, Ctr Cardiol, Prevent Cardiol & Prevent Med, Mainz, Germany.
   [Wild, Philipp S.] Johannes Gutenberg Univ Mainz, Univ Med Ctr, Ctr Thrombosis & Hemostasis, Mainz, Germany.
   [Wild, Philipp S.] DZHK German Ctr Cardiovasc Res, Partner Site RhineMain, Mainz, Germany.
   [Lackner, Karl J.] Johannes Gutenberg Univ Mainz, Univ Med Ctr, Inst Clin Chem & Lab Med, Mainz, Germany.
   [Blettner, Maria] Johannes Gutenberg Univ Mainz, Univ Med Ctr, Inst Med Biostat Epidemiol & Informat, Mainz, Germany.
   [Pfeiffer, Norbert] Johannes Gutenberg Univ Mainz, Univ Med Ctr, Dept Ophthalmol, Mainz, Germany.
C3 Johannes Gutenberg University of Mainz; Johannes Gutenberg University of
   Mainz; Johannes Gutenberg University of Mainz; Johannes Gutenberg
   University of Mainz; German Centre for Cardiovascular Research; Johannes
   Gutenberg University of Mainz; Johannes Gutenberg University of Mainz;
   Johannes Gutenberg University of Mainz
RP Wiltink, J (corresponding author), Johannes Gutenberg Univ Mainz, Univ Med Ctr, Dept Psychosomat Med & Psychotherapy, Mainz, Germany.
EM joerg.wiltink@unimedizin-mainz.de
RI Pfeiffer, Norbert/AAO-7586-2020; Lackner, Karl/IAQ-4908-2023; Wild,
   Philipp/M-2106-2019; Braehler, Elmar/C-6535-2009; Muenzel,
   Thomas/A-2912-2014
OI Brahler, Elmar/0000-0002-2648-2728; Wild, Philipp/0000-0003-4413-9752;
   Muenzel, Thomas/0000-0001-5503-4150
FU government of Rhineland-Palatinate ("Stiftung Rheinland-Pfalz fur
   Innovation") [AZ 961-386261/733]; research program "Wissen schafft
   Zukunft" of the Johannes Gutenberg-University of Mainz; research program
   "Center for Translational Vascular Biology (CTVB)" of the Johannes
   Gutenberg-University of Mainz; Federal Ministry of Education and
   Research [BMBF 01EO1503]; Boehringer Ingelheim; PHILIPS Medical Systems
FX The Gutenberg Health Study is funded through the government of
   Rhineland-Palatinate ("Stiftung Rheinland-Pfalz fur Innovation",
   contract AZ 961-386261/733), the research programs "Wissen schafft
   Zukunft" and "Center for Translational Vascular Biology (CTVB)" of the
   Johannes Gutenberg-University of Mainz, and its contract with Boehringer
   Ingelheim and PHILIPS Medical Systems, including an unrestricted grant
   for the Gutenberg Health Study. Philipp S. Wild is funded by the Federal
   Ministry of Education and Research (BMBF 01EO1503) and he is PI of the
   German Center for Cardiovascular Research (DZHK).
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NR 45
TC 8
Z9 9
U1 0
U2 2
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1471-244X
J9 BMC PSYCHIATRY
JI BMC Psychiatry
PD APR 27
PY 2018
VL 18
AR 114
DI 10.1186/s12888-018-1691-1
PG 10
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA GE6EO
UT WOS:000431317500001
PM 29699530
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Gardner-Sood, P
   Lally, J
   Smith, S
   Atakan, Z
   Ismail, K
   Greenwood, KE
   Keen, A
   O'Brien, C
   Onagbesan, O
   Fung, C
   Papanastasiou, E
   Eberherd, J
   Patel, A
   Ohlsen, R
   Stahl, D
   David, A
   Hopkins, D
   Murray, RM
   Gaughran, F
AF Gardner-Sood, P.
   Lally, J.
   Smith, S.
   Atakan, Z.
   Ismail, K.
   Greenwood, K. E.
   Keen, A.
   O'Brien, C.
   Onagbesan, O.
   Fung, C.
   Papanastasiou, E.
   Eberherd, J.
   Patel, A.
   Ohlsen, R.
   Stahl, D.
   David, A.
   Hopkins, D.
   Murray, R. M.
   Gaughran, F.
CA IMPaCT Team
TI Cardiovascular risk factors and metabolic syndrome in people with
   established psychotic illnesses: baseline data from the IMPaCT
   randomized controlled trial
SO PSYCHOLOGICAL MEDICINE
LA English
DT Article
DE Metabolic syndrome; physical health; psychotic disorder; schizophrenia;
   severe mental illnesses
ID CATIE SCHIZOPHRENIA TRIAL; CLINICAL ANTIPSYCHOTIC TRIALS; SERIOUS
   MENTAL-ILLNESS; PHYSICAL-ACTIVITY; PREVALENCE; MORTALITY; INTERVENTION;
   SMOKING; ABNORMALITIES; METAANALYSIS
AB Background The aims of the study were to determine the prevalence of cardiometabolic risk factors and establish the proportion of people with psychosis meeting criteria for the metabolic syndrome (MetS). The study also aimed to identify the key lifestyle behaviours associated with increased risk of the MetS and to investigate whether the MetS is associated with illness severity and degree of functional impairment.
   Method Baseline data were collected as part of a large randomized controlled trial (IMPaCT RCT). The study took place within community mental health teams in five Mental Health NHS Trusts in urban and rural locations across England. A total of 450 randomly selected out-patients, aged 18-65 years, with an established psychotic illness were recruited. We ascertained the prevalence rates of cardiometabolic risk factors, illness severity and functional impairment and calculated rates of the MetS, using International Diabetes Federation (IDF) and National Cholesterol Education Program Third Adult Treatment Panel criteria.
   Results High rates of cardiometabolic risk factors were found. Nearly all women and most men had waist circumference exceeding the IDF threshold for central obesity. Half the sample was obese (body mass index 30 kg/m(2)) and a fifth met the criteria for type 2 diabetes mellitus. Females were more likely to be obese than males (61% v. 42%, p < 0.001). Of the 308 patients with complete laboratory measures, 57% (n = 175) met the IDF criteria for the MetS.
   Conclusions In the UK, the prevalence of cardiometabolic risk factors in individuals with psychotic illnesses is much higher than that observed in national general population studies as well as in most international studies of patients with psychosis.
C1 [Gardner-Sood, P.; Lally, J.; Atakan, Z.; Murray, R. M.] Kings Coll London, Inst Psychiat Psychol & Neurosci IoPPN, Dept Psychosis Studies, London SE5 8AF, England.
   [Lally, J.; Murray, R. M.; Gaughran, F.] South London & Maudsley NHS Fdn Trust, Natl Psychosis Serv, London, England.
   [Smith, S.; Ismail, K.; Keen, A.; O'Brien, C.; Fung, C.; Papanastasiou, E.; Eberherd, J.; David, A.] Kings Coll London, Inst Psychiat Psychol & Neurosci IoPPN, London SE5 8AF, England.
   [Smith, S.] South London & Maudsley NHS Fdn Trust, London, England.
   [Ismail, K.] Kings Coll Hosp NHS Fdn Trust, London, England.
   [Greenwood, K. E.] Univ Sussex, Sch Psychol, Brighton & Early Intervent Psychosis Serv, Sussex Partnership NHS Fdn Trust, Brighton, W Sussex, England.
   [Onagbesan, O.] NIHR Biomed Res Ctr, BioResource Mental Hlth Social Genet & Dev Psychi, London, England.
   [Eberherd, J.] Lund Univ, Clin Sci, Malmo, Sweden.
   [Patel, A.] Kings Coll London, Inst Psychiat Psychol & Neurosci IoPPN, CEMPH, London SE5 8AF, England.
   [Ohlsen, R.] Kings Coll London, Florence Nightingale Fac Nursing & Midwifery, London SE5 8AF, England.
   [Stahl, D.] Kings Coll London, Inst Psychiat Psychol & Neurosci IoPPN, Dept Biostat, London SE5 8AF, England.
   [Hopkins, D.] Kings Coll Hosp NHS Fdn Trust, Div Ambulatory Care & Local Networks, London, England.
   [Hopkins, D.] Kings Coll London, Sch Med, London SE5 8AF, England.
   [Gaughran, F.] South London & Maudsley NHS Fdn Trust, Maudsley Hosp, Inst Psychiat Psychol & Neurosci IoPPN, London, England.
   [Gaughran, F.] South London & Maudsley NHS Fdn Trust, Maudsley Hosp, BRC Nucleus, Biomed Res Ctr, London, England.
C3 University of London; King's College London; South London & Maudsley NHS
   Trust; University of London; King's College London; South London &
   Maudsley NHS Trust; King's College Hospital NHS Foundation Trust;
   University of Sussex; Lund University; University of London; King's
   College London; University of London; King's College London; University
   of London; King's College London; King's College Hospital NHS Foundation
   Trust; University of London; King's College London; South London &
   Maudsley NHS Trust; Maudsley Hospital; South London & Maudsley NHS
   Trust; Maudsley Hospital
RP Gaughran, F (corresponding author), Kings Coll London, Inst Psychiat Psychol & Neurosci IoPPN, Dept Psychosis Studies, PO63,De Crespigny Pk, London SE5 8AF, England.
EM Fiona.1.gaughran@kcl.ac.uk
RI Papanastasiou, Evangelos/D-3071-2011; greenwood, kathryn/I-8638-2012;
   Hopkins, David/AAP-4541-2020; Gaughran, Fiona/AAC-7160-2019; Patel,
   Anita/F-9832-2010; David, Anthony/O-1750-2019; Stahl,
   Daniel/B-9713-2011; Gaughran, Fiona/H-5495-2011; David,
   Anthony/C-1315-2011; murray, robin/F-8658-2012
OI Gaughran, Fiona/0000-0001-7414-5569; Lally, John/0000-0003-3038-0625;
   David, Anthony/0000-0003-0967-774X; murray, robin/0000-0003-0829-0519;
   Hopkins, David/0000-0002-0451-0900; Patel, Anita/0000-0003-0769-1732;
   Onagbesan, Okanlawon/0000-0002-9019-8828; Greenwood,
   Kathryn/0000-0001-7899-8980
FU National Institute for Health Research [RP-PG-0606-1049]; National
   Institutes of Health Research (NIHR) [RP-PG-0606-1049] Funding Source:
   National Institutes of Health Research (NIHR)
FX The National Institute for Health Research funds the IMPaCT programme at
   King's College London and the South London and Maudsley NHS Foundation
   Trust (ref. RP-PG-0606-1049). The funding source(s) had no role in the
   design of this study and did not have any role during its execution,
   analyses, interpretation of the data, or decision to submit results. We
   affirm that the paper is an honest, accurate and transparent account of
   the study being reported; that no important aspects of the study have
   been omitted; and that any discrepancies from the study as planned (and,
   if relevant, registered) have been explained.
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NR 68
TC 107
Z9 116
U1 0
U2 24
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
SN 0033-2917
EI 1469-8978
J9 PSYCHOL MED
JI Psychol. Med.
PD SEP
PY 2015
VL 45
IS 12
BP 2619
EP 2629
DI 10.1017/S0033291715000562
PG 11
WC Psychology, Clinical; Psychiatry; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA CO6TV
UT WOS:000359290100013
PM 25961431
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Ohmori, Y
   Ito, H
   Morita, A
   Deura, K
   Miyachi, M
AF Ohmori, Yumi
   Ito, Hiroto
   Morita, Akemi
   Deura, Kijo
   Miyachi, Motohiko
CA Saku Cohort Study Grp
TI Associations between depression and unhealthy behaviours related to
   metabolic syndrome: a cross sectional study
SO ASIA PACIFIC JOURNAL OF CLINICAL NUTRITION
LA English
DT Article
DE depression; metabolic syndrome; unhealthy behaviours; physical activity;
   dietary intake and habits
ID DIET HISTORY QUESTIONNAIRE; MENTAL-HEALTH; HEART-DISEASE; LIFE-STYLE;
   SYMPTOMS; VALIDITY; ANXIETY; CHOLESTEROL; DISORDER; ADULTS
AB Background and Objectives: The purpose of the present study was to determine whether depression was associated with metabolic syndrome and unhealthy behaviours in community residents. Methods and Study Design: Using the 2009-2010 baseline data of the Saku Cohort Study, 1,225 men and women who participated in a community health screening were included in the cross-sectional analyses. Depression was assessed using the Zung Self-Rating Depression Scale. Consistent with the Japanese Society of Internal Medicine's definition, we defined metabolic syndrome as abdominal obesity plus two or more of the following: high blood pressure, hyperglycaemia, and dyslipidaemia. We defined 'pre- and metabolic syndrome' as the presence of one or more of the three criteria in addition to abdominal obesity. Results: There was no significant association between depression and metabolic syndrome. In women, the prevalence of pre- and metabolic syndrome was significantly higher in the depression group than that in the non-depression group (17.5% vs 9.5%, p=0.046), whereas no such significant association was observed in men. Logistic regression analysis showed that depression was associated with unhealthy behavioural factors differently in men and women. Conclusions: This study revealed that depression was associated with several unhealthy behavioural factors in both men and women, but depression was associated with pre- and metabolic syndrome only in women. These findings suggest that depression may be a warning sign of metabolic syndrome in women with unhealthy behavioural factors. Psychological factors should be considered in addition to the assessment of physical status.
C1 [Ohmori, Yumi; Ito, Hiroto] Natl Ctr Neurol & Psychiat, Dept Social Psychiat, Natl Inst Mental Hlth, 4-1-1 Ogawa Higashi, Kodaira, Tokyo 1878553, Japan.
   [Ohmori, Yumi; Miyachi, Motohiko] Natl Inst Hlth & Nutr, Dept Hlth Promot & Exercise, Tokyo, Japan.
   [Ohmori, Yumi] Univ Tsukuba, Dept Human Care Sci, Grad Sch Comprehens Human Sci, Ibaraki, Japan.
   [Morita, Akemi] Koshien Univ, Fac Nutr, Takarazuka, Hyogo, Japan.
   [Deura, Kijo] Saku Cent Hosp, Nagano, Japan.
C3 National Center for Neurology & Psychiatry - Japan; National Institute
   of Health & Nutrition - Japan; University of Tsukuba
RP Ohmori, Y (corresponding author), Natl Ctr Neurol & Psychiat, Dept Social Psychiat, Natl Inst Mental Hlth, 4-1-1 Ogawa Higashi, Kodaira, Tokyo 1878553, Japan.
EM yohmori@ncnp.go.jp
RI Miyachi, Motohiko/AAW-3403-2020
OI Morita, Akemi/0000-0001-7942-6415; Miyachi, Motohiko/0000-0002-1146-0905
FU Research-in-Aid for Cardiovascular Diseases, Ministry of Health, Labour
   and Welfare in Japan [H21-Jyunkankitou-Seisyu-Ippan-013]
FX The authors are indebted to the dedicated and committed participants of
   this study. We are grateful for the invaluable contribution of Shaw
   Watanabe (Life Science Promoting Association, Tokyo, Japan). We are
   thankful to medical staff and colleagues for supporting this study in
   Saku Central Hospital for their kind cooperation. We thank Sayuri
   Hashimoto (University of Tsukuba, Ibaraki, Japan) for her advice on this
   study. This study was supported by Research-in-Aid for Cardiovascular
   Diseases, Ministry of Health, Labour and Welfare in Japan (Grant number:
   H21-Jyunkankitou-Seisyu-Ippan-013).
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NR 44
TC 19
Z9 22
U1 0
U2 7
PU H E C PRESS, HEALTHY EATING CLUB PTY LTD
PI MCKINNON
PA PO BOX 4121, MCKINNON, VIC 3204, AUSTRALIA
SN 0964-7058
EI 1440-6047
J9 ASIA PAC J CLIN NUTR
JI Asia Pac. J. Clin. Nutr.
PD JAN
PY 2017
VL 26
IS 1
BP 130
EP 140
DI 10.6133/apjcn.112015.01
PG 11
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nutrition & Dietetics
GA EI1TD
UT WOS:000392259900020
PM 28049272
DA 2025-06-11
ER

PT J
AU Grammatikopoulou, MG
   Lampropoulou, MA
   Milapidou, M
   Goulis, DG
AF Grammatikopoulou, Maria G.
   Lampropoulou, Maria A.
   Milapidou, Maria
   Goulis, Dimitrios G.
TI At the heart of the matter: Cardiovascular health challenges among
   incarcerated women
SO MATURITAS
LA English
DT Review
DE Prison; Nutrition; Obesity; Jail; Prisoner; Diabetes mellitus; Mental
   health; Psychological health
ID DISEASE RISK-FACTORS; MENTAL-HEALTH; PHYSICAL-ACTIVITY; SUBSTANCE-ABUSE;
   MALE PRISONERS; HIV-INFECTION; WEIGHT-GAIN; CARE; MENOPAUSE; DIET
AB Many factors appear to contribute to an increased risk for cardiovascular disease (CVD) among incarcerated women. Imprisonment is associated with a bodyweight gain and an increased prevalence of overweight and obesity. Inadequate physical activity and unhealthy nutrition further contribute to this positive energy balance. Classical CVD risk factors are common, including hypertension, diabetes mellitus, metabolic syndrome, and smoking. Moreover, imprisonment is associated with an increased incidence of mental health issues, such as depression and anxiety, with coping mechanisms, including substance abuse, being frequently adopted. Specific attitudes in the correctional environment, including hunger strikes, bullying, abuse and solitary confinement, are effectors of cardiovascular and mental ill-health. Furthermore, the plethora of psychological stressors induces an accelerated aging process, paired with CVD risk. Communicable diseases, mainly human immunodeficiency virus, opportunistic infections and inadequate sunlight exposure increase cardiovascular dysregulation. Health care needs associated with the female sex are not always met, adding to the frustration and compromised wellbeing. All these factors act independently and cumulatively, increasing CVD risk among incarcerated women.
C1 [Grammatikopoulou, Maria G.; Goulis, Dimitrios G.] Aristotle Univ Thessaloniki, Fac Hlth Sci, Med Sch, Unit Reprod Endocrinol,Dept Obstet & Gynecol 1, Thessaloniki, Greece.
   [Grammatikopoulou, Maria G.; Lampropoulou, Maria A.] Int Hellen Univ, Fac Hlth Sci, Dept Nutr Sci & Dietet, Alexander Campus, Thessaloniki, Greece.
   [Milapidou, Maria] Aristotle Univ Thessaloniki, Fac Law, Thessaloniki, Greece.
C3 Aristotle University of Thessaloniki; International Hellenic University;
   Aristotle University of Thessaloniki
RP Goulis, DG (corresponding author), Aristotle Univ Thessaloniki, Fac Hlth Sci, Med Sch, Unit Reprod Endocrinol,Dept Obstet & Gynecol 1, Thessaloniki, Greece.
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NR 170
TC 6
Z9 7
U1 4
U2 19
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0378-5122
EI 1873-4111
J9 MATURITAS
JI Maturitas
PD JUL
PY 2021
VL 149
BP 16
EP 25
DI 10.1016/j.maturitas.2021.05.002
EA MAY 2021
PG 10
WC Geriatrics & Gerontology; Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Obstetrics & Gynecology
GA SS0GY
UT WOS:000661422100003
PM 34134886
DA 2025-06-11
ER

PT J
AU Kuo, WC
   Bratzke, LC
   Oakley, LD
   Kuo, FL
   Wang, HC
   Brown, RL
AF Kuo, Wan-chin
   Bratzke, Lisa C.
   Oakley, Linda D.
   Kuo, Fanglin
   Wang, Haocen
   Brown, Roger L.
TI The association between psychological stress and metabolic syndrome: A
   systematic review and meta-analysis
SO OBESITY REVIEWS
LA English
DT Review
DE metabolic syndrome; occupational stress; perceived stress; psychological
   stress
ID CORONARY-HEART-DISEASE; PSYCHOSOCIAL RISK-FACTORS; EFFORT-REWARD
   IMBALANCE; WORK-RELATED STRESS; LIFE EVENTS; JOB STRAIN; PERCEIVED
   STRESS; PHYSICAL-ACTIVITY; HEALTH; OBESITY
AB Literature suggests that occupational stress is associated with a higher risk of metabolic syndrome; yet less is known whether other sources of stress have similar effects. This review aims to examine whether the relationship between psychological stress and metabolic syndrome differs by sources of stress. Three databases (PubMed, Web of Science, and CINAHL) were searched for eligible articles; meta-analyses were conducted using the random effects model. After controlling for covariates, adults in the high-stress groups had 45% higher chance of having metabolic syndrome than adults in the low-stress groups (odds ratio [OR] = 1.450; 95% confidence interval [CI], 1.211-1.735; P < .001). The subsequent meta-analysis based on cross-sectional studies suggested that occupational stress showed the strongest effect (OR = 1.692; 95% CI, 1.182-2.424; P = .004), while perceived general stress showed the weakest effect (OR = 1.217; 95% CI, 1.017-1.457; P = .032). Unfortunately, there is a lack of longitudinal studies for subsequent meta-analysis based on sources of stress. There is a need for continued research to examine the long-term relationship between different sources of stress and the risk of metabolic syndrome. Traditional recommendations for preventing metabolic syndrome (eg, low-fat diet and exercise) may not achieve the best outcome if clinicians overlook patients' psychosocial stress.
C1 [Kuo, Wan-chin; Bratzke, Lisa C.; Oakley, Linda D.; Wang, Haocen; Brown, Roger L.] Univ Wisconsin, Sch Nursing, Signe Skott Cooper Hall,701 Highland Ave, Madison, WI 53705 USA.
   [Kuo, Fanglin] Taiwan Natl Inst Hlth, Infect Dis & Vaccinol, Taipei, Taiwan.
C3 University of Wisconsin System; University of Wisconsin Madison
RP Kuo, WC (corresponding author), Univ Wisconsin, Sch Nursing, Signe Skott Cooper Hall,701 Highland Ave, Madison, WI 53705 USA.
EM wanchinya@gmail.com
RI Kuo, Wan-Chin/AAR-8962-2020
OI Wang, Haocen/0000-0001-5173-7051; Kuo, Wan-chin/0000-0002-5658-6077
FU Johnson Research Award from University of Wisconsin-Madison School of
   Nursing
FX Johnson Research Award from University of Wisconsin-Madison School of
   Nursing
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NR 67
TC 82
Z9 95
U1 1
U2 39
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1467-7881
EI 1467-789X
J9 OBES REV
JI Obes. Rev.
PD NOV
PY 2019
VL 20
IS 11
BP 1651
EP 1664
DI 10.1111/obr.12915
EA JUL 2019
PG 14
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism
GA JF6DA
UT WOS:000479491900001
PM 31347765
DA 2025-06-11
ER

PT J
AU Ceyhun, HA
   Bilen, H
AF Ceyhun, Hacer Akgul
   Bilen, Handan
TI Eating Attitudes From a Cardiometabolic Risk Perspective: Psoriasis
   Sample
SO CLINICAL AND EXPERIMENTAL HEALTH SCIENCES
LA English
DT Article
DE anxiety; eating attitude; psoriasis; metabolic syndrome; obesity
ID METABOLIC SYNDROME; OBESITY; PREVALENCE; INDEX; LIFE
AB Objective: In this study, we aimed to compare psoriasis patients with healthy controls in terms of impaired eating attitudes and to investigate the relationship of eating attitudes with cardiometabolic and clinical parameters, anxiety, depression, and quality of life.
   Methods: 45 psoriasis patients and 45 healthy controls were included in the study. Personal and clinical information form, eating attitude test (EAT-40), body mass index (BMI) and MetS criteria were used for all participants. Psoriasis patients were evaluated with clinical information form, hospital anxiety and depression scale (HADS), dermatological quality of life index (DQLI), psoriasis area and severity index (PASI).
   Results: The data of the patient and control groups differed in terms of doing sports, impaired EAT, BMI groups, and metabolic syndrome (MetS). Abnormal eating attitudes such as negative body image, inability to control oneself in eating, overeating, and some restrictive attitudes were significantly higher in the psoriasis group. Overeating, overeating or stress-induced emotional eating, presence of MetS, weight dissatisfaction, frequent dieting to lose weight, some compensatory behaviours, and loss of self-control were significantly higher in patients with BMI>25. EAT points; showed a positive moderate correlation with BMI and HAD-Anxiety. DQLI results; showed a moderate positive correlation with HAD-Anxiety and PASI scores.
   Conclusion: Our study is the first to reveal what kind of disordered eating attitudes are at risk for cardiometabolic diseases in psoriasis patients. In psoriasis patients, the rate of not being able to control their eating behaviour is high. Our results primarily highlight the relationship that can be explained by autonomic reactivity between anxiety and difficulty resisting food cravings. Professional support including psychoeducation, cognitive behavioural therapy, and acceptance-based therapies should be provided to reduce maladaptive reactions and anxiety by improving self-regulation skills.
C1 [Ceyhun, Hacer Akgul] Ataturk Univ, Dept Psychiat, Fac Med, Erzurum, Turkiye.
   [Bilen, Handan] Ataturk Univ, Dept Dermatol, Fac Med, Erzurum, Turkiye.
C3 Ataturk University; Ataturk University
RP Ceyhun, HA (corresponding author), Ataturk Univ, Dept Psychiat, Fac Med, Erzurum, Turkiye.
EM hacer.ceyhun@atauni.edu.tr
RI Bilen, Handan/AGO-5649-2022; CEYHUN, HACER AKGUL/HNS-7753-2023
OI CEYHUN, HACER AKGUL/0000-0002-1831-7634
CR Acar EM, 2019, DERMATOL SIN, V37, P33, DOI 10.4103/ds.ds_9_18
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NR 30
TC 0
Z9 0
U1 1
U2 1
PU MARMARA UNIV, INST HEALTH SCIENCES
PI ISTANBUL
PA MARMARA U BASIBUYUK SAGLIK YERLESKESI, SAGLIK BILIMLERI ENSTITUSU
   MUDURLUGU, BASIBUYUK YOLU 9-3, ISTANBUL, 34854, Turkiye
SN 2459-1459
J9 CLIN EXP HEALTH SCI
JI Clin. Exp. Health Sci.
PD SEP
PY 2023
VL 13
IS 3
BP 584
EP 592
DI 10.33808/clinexphealthsci.1146966
PG 9
WC Medicine, Research & Experimental
WE Emerging Sources Citation Index (ESCI)
SC Research & Experimental Medicine
GA GN6B4
UT WOS:001153376600021
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Renna, ME
   Wilbourne, FN
   Johal, S
   Fergerson, AK
   Behringer, KF
   Brandner, CF
   Stavres, J
   Graybeal, AJ
AF Renna, Megan E.
   Wilbourne, Faith N.
   Johal, Sonal
   Fergerson, Ava K.
   Behringer, Kylee F.
   Brandner, Caleb F.
   Stavres, Jon
   Graybeal, Austin J.
TI Stress and Anxiety Are Associated with Increased Metabolic Syndrome Risk
   Among Young Adults Living in the Deep South
SO HEALTHCARE
LA English
DT Article
DE metabolic syndrome; anxiety; depression; stress; eating behavior;
   metabolic risk
ID PERCEIVED STRESS; UNITED-STATES; DEPRESSION; METAANALYSIS; PREVALENCE;
   TRENDS
AB Background/Objectives: This study assessed the association among perceived stress, anxiety, and depression with both the metabolic syndrome (MetS) risk and diagnostic status among young adults in the Deep South. Methods: Participants included 132 young adults aged 18-39 (Mage = 27.73, SD = 11.11; MBMI = 27.6, SD = 6.8; 56.5% female; 55.7% White) living in Mississippi. In addition to completing self-report measures of perceived stress, anxiety, and depression, all of the participants underwent anthropometric, blood pressure, and fasting blood glucose and lipid assessments to ascertain the MetS status. The participants were provided with both a MetS diagnosis (defined as a dichotomous yes/no variable) as well as a continuous MetS risk severity score determined using existing equations. The risk scores ranged from -1 to +1, with positive scores indicating an increased risk for MetS. Results: After controlling for age, biological sex, race, medication use, and education level, multiple regression models revealed significant positive relationships between perceived stress (b = 0.03; p = 0.017) and anxiety symptoms (b = 0.01; p = 0.039) with the MetS severity. Perceived stress (p = 0.017) and anxiety symptoms (p = 0.043) were also significantly higher among participants with MetS compared to those without. There were no significant associations between the MetS severity and depressive symptoms, and no differences in depressive symptoms in participants with versus without MetS. Conclusions: The results highlight the role of stress and anxiety not only in MetS but in the overall metabolic risk among young adults living in the Deep South. The results highlight the importance of intervening on stress and anxiety early in adulthood to help mitigate cardiometabolic health risk.
C1 [Renna, Megan E.; Wilbourne, Faith N.; Johal, Sonal; Fergerson, Ava K.; Behringer, Kylee F.] Univ Southern Mississippi, Sch Psychol, Hattiesburg, MS 39406 USA.
   [Brandner, Caleb F.] Iowa State Univ, Dept Kinesiol, Ames, IA 50011 USA.
   [Stavres, Jon; Graybeal, Austin J.] Univ Southern Mississippi, Sch Kinesiol & Nutr, Hattiesburg, MS 39406 USA.
C3 University of Southern Mississippi; Iowa State University; University of
   Southern Mississippi
RP Renna, ME (corresponding author), Univ Southern Mississippi, Sch Psychol, Hattiesburg, MS 39406 USA.
EM megan.renna@usm.edu
RI Renna, Megan/AAF-9415-2019; Stavres, Jon/JTS-7791-2023; Graybeal,
   Austin/AAO-5501-2021
OI Stavres, Jon/0000-0003-0564-7252; Graybeal, Austin/0000-0003-4520-9230
CR [Anonymous], National Center for Health Statistics Center for Disease Control and Prevention. [Available from: https://www.cdc.gov/nchs/].
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NR 27
TC 0
Z9 0
U1 1
U2 1
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2227-9032
J9 HEALTHCARE-BASEL
JI Healthcare
PD FEB
PY 2025
VL 13
IS 4
AR 359
DI 10.3390/healthcare13040359
PG 10
WC Health Care Sciences & Services; Health Policy & Services
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services
GA Y4O8V
UT WOS:001431946300001
PM 39997234
OA gold
DA 2025-06-11
ER

PT J
AU Robinson, DJ
   Luthra, M
   Vallis, M
AF Robinson, David J.
   Luthra, Meera
   Vallis, Michael
CA Canadian Diabet Assoc Clinical Pra
TI Diabetes and Mental Health
SO CANADIAN JOURNAL OF DIABETES
LA English
DT Article
ID IMPROVE GLYCEMIC CONTROL; FAMILY SYSTEMS THERAPY; CO-MORBID DEPRESSION;
   METABOLIC SYNDROME; DOUBLE-BLIND; INSULIN-RESISTANCE; MAJOR DEPRESSION;
   EATING-DISORDERS; RANDOMIZED-TRIAL; PSYCHOLOGICAL INTERVENTIONS
C1 [Robinson, David J.] Bluewater Hlth, London, ON, Canada.
   [Luthra, Meera] McMaster Univ, Dept Med, Div Endocrinol & Metab, Hamilton, ON, Canada.
   [Luthra, Meera] Diabet Program, Hamilton, ON, Canada.
   [Vallis, Michael] Capital Hlth, Behav Change Inst, Halifax, NS, Canada.
   [Vallis, Michael] Dalhousie Univ, Halifax, NS, Canada.
C3 McMaster University; Dalhousie University
RP Robinson, DJ (corresponding author), Bluewater Hlth, London, ON, Canada.
RI Vallis, Michael/R-8965-2019
OI Vallis, Michael/0000-0002-0165-5936
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NR 113
TC 45
Z9 52
U1 1
U2 18
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1499-2671
EI 2352-3840
J9 CAN J DIABETES
JI Can. J. Diabetes
PD APR
PY 2013
VL 37
SU 1
BP S87
EP S92
DI 10.1016/j.jcjd.2013.01.026
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA AL8QM
UT WOS:000339404000018
PM 24070971
DA 2025-06-11
ER

PT J
AU Kim, S
   Zhang, WH
   Pak, V
   Aqua, JK
   Hertzberg, VS
   Spahr, CM
   Slavich, GM
   Bai, JB
AF Kim, Sangmi
   Zhang, Wenhui
   Pak, Victoria
   Aqua, Jasmine Ko
   Hertzberg, Vicki Stover
   Spahr, Chandler M.
   Slavich, George M.
   Bai, Jinbing
TI How stress, discrimination, acculturation and the gut microbiome affect
   depression, anxiety and sleep among Chinese and Korean immigrants in the
   USA: a cross-sectional pilot study protocol
SO BMJ OPEN
LA English
DT Article
DE public health; social medicine; mental health
ID MENTAL-HEALTH; RACIAL-DISCRIMINATION; METABOLIC SYNDROME;
   ETHNIC-IDENTITY; UNITED-STATES; SAMPLE-SIZE; ASSOCIATION; AMERICANS;
   SYMPTOMS; DISTURBANCES
AB Introduction Although a considerable proportion of Asians in the USA experience depression, anxiety and poor sleep, these health issues have been underestimated due to the model minority myth about Asians, the stigma associated with mental illness, lower rates of treatment seeking and a shortage of culturally tailored mental health services. Indeed, despite emerging evidence of links between psychosocial risk factors, the gut microbiome and depression, anxiety and sleep quality, very few studies have examined how these factors are related in Chinese and Korean immigrants in the USA. The purpose of this pilot study was to address this issue by (a) testing the usability and feasibility of the study's multilingual survey measures and biospecimen collection procedure among Chinese and Korean immigrants in the USA and (b) examining how stress, discrimination, acculturation and the gut microbiome are associated with depression, anxiety and sleep quality in this population. Method and analysis This is a cross-sectional pilot study among first and second generations of adult Chinese and Korean immigrants in the greater Atlanta area (Georgia, USA). We collected (a) gut microbiome samples and (b) data on psychosocial risk factors, depression, anxiety and sleep disturbance using validated, online surveys in English, Chinese and Korean. We aim to recruit 60 participants (30 Chinese, 30 Korean). We will profile participants' gut microbiome using 16S rRNA V3-V4 sequencing data, which will be analysed by QIIME 2. Associations of the gut microbiome and psychosocial factors with depression, anxiety and sleep disturbance will be analysed using descriptive and inferential statistics, including linear regression. Ethics and dissemination This study has been approved by the Institutional Review Board at Emory University (IRB ID: STUDY00000935). Results will be made available to Chinese and Korean community members, the funder and other researchers and the broader scientific community.
C1 [Kim, Sangmi; Zhang, Wenhui; Pak, Victoria; Hertzberg, Vicki Stover; Bai, Jinbing] Emory Univ, Nell Hodgson Woodruff Sch Nursing, Atlanta, GA 30322 USA.
   [Zhang, Wenhui; Hertzberg, Vicki Stover] Emory Univ, Nell Hodgson Woodruff Sch Nursing, Ctr Data Sci, Atlanta, GA 30322 USA.
   [Aqua, Jasmine Ko] Emory Univ, Rollins Sch Publ Hlth, Dept Epidemiol, Atlanta, GA USA.
   [Spahr, Chandler M.] Univ Calif Riverside, Dept Psychol, Riverside, CA 92521 USA.
   [Slavich, George M.] Univ Calif Los Angeles, Cousins Ctr Psychoneuroimmunol, Los Angeles, CA USA.
   [Slavich, George M.] Univ Calif Los Angeles, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90024 USA.
   [Bai, Jinbing] Emory Univ, Winship Canc Inst, Atlanta, GA 30322 USA.
C3 Emory University; Emory University; Emory University; Rollins School
   Public Health; University of California System; University of California
   Riverside; University of California System; University of California Los
   Angeles; University of California System; University of California Los
   Angeles; Emory University
RP Bai, JB (corresponding author), Emory Univ, Nell Hodgson Woodruff Sch Nursing, Atlanta, GA 30322 USA.; Bai, JB (corresponding author), Emory Univ, Winship Canc Inst, Atlanta, GA 30322 USA.
EM jinbing.bai@emory.edu
RI Slavich, George/C-6208-2008; Bai, Jinbing/A-2613-2017
OI Pak, Victoria/0000-0002-4081-8347; Aqua, Jasmine/0000-0002-4226-8748
FU Office of the Senior Vice President for Research at Emory University
   (Bidirectional Global Health Disparities Research Pilot Grant); National
   Institute of Health/National Institute of Nursing Research
   [1K99NR017897-01, 4R00NR017897-03]; Society in Science-Branco Weiss
   Fellowship; NARSAD Young Investigator Grant from the Brain & Behavior
   Research Foundation [23958]; National Institutes of Health [K08
   MH103443]
FX This work was supported by the Office of the Senior Vice President for
   Research at Emory University (Bidirectional Global Health Disparities
   Research Pilot Grant, JB and SK) and National Institute of
   Health/National Institute of Nursing Research (1K99NR017897-01,
   4R00NR017897-03, JB). GS was supported by a Society in Science-Branco
   Weiss Fellowship, NARSAD Young Investigator Grant #23958 from the Brain
   & Behavior Research Foundation and National Institutes of Health grant
   K08 MH103443.
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U1 3
U2 19
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2044-6055
J9 BMJ OPEN
JI BMJ Open
PY 2021
VL 11
IS 7
AR e047281
DI 10.1136/bmjopen-2020-047281
PG 10
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA UK2UD
UT WOS:000691829200007
PM 34290066
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Tronieri, JS
   Wurst, CM
   Pearl, RL
   Allison, KC
AF Tronieri, Jena Shaw
   Wurst, Courtney McCuen
   Pearl, Rebecca L.
   Allison, Kelly C.
TI Sex Differences in Obesity and Mental Health
SO CURRENT PSYCHIATRY REPORTS
LA English
DT Review
DE Obesity; Depression; Anxiety; PTSD; Substance use disorders; Eating
   disorders; Weight stigma
ID POSTTRAUMATIC-STRESS-DISORDER; WEIGHT BIAS INTERNALIZATION; BINGE-EATING
   DISORDER; BODY-MASS INDEX; PSYCHIATRIC-DISORDERS; LONGITUDINAL
   ASSOCIATIONS; METABOLIC SYNDROME; PALATABLE FOOD; ANIMAL-MODEL;
   DEPRESSION
AB Purpose of Review The purposes of this study were to examine the relationships between obesity and a wide range of mental health issues and to identify where sex differences exist and may vary across disorders.
   Recent Findings Research on sex differences in the relationship between obesity and psychiatric disorders is more abundant in some areas, such as depression and eating disorders, than others, such as anxiety, trauma, and substance use. However, for most of the disorders, their relationships with obesity and sex are complex and are usually moderated by additional variables. Thus, studies that find stronger relationships for women between depression and obesity cross-sectionally do not tell the whole story, as longitudinal studies suggest that this relationship may also be present among men, particularly when confounders are considered. For those with eating disorders, men and women with obesity are fairly equally affected, and weight and shape concerns may play a role in maintaining these behaviors for both sexes. Weight stigma, though, seems to have worse consequences for women than men with obesity.
   Summary Sex differences exist in relation to the associations between mental health and obesity. However, these differences vary by disorder, with disorder-specific moderators playing a role, such as age for depressive disorders, comorbid depression for anxiety disorders, and weight and shape concerns for eating disorders. More work is needed to understand if sex differences play a role in the relationship between obesity and anxiety, trauma, and substance use disorders.
C1 [Tronieri, Jena Shaw; Wurst, Courtney McCuen; Pearl, Rebecca L.; Allison, Kelly C.] Univ Penn, Perelman Sch Med, Dept Psychiat, Ctr Weight & Eating Disorders, 3535 Market St,3rd Floor, Philadelphia, PA 19104 USA.
C3 University of Pennsylvania
RP Allison, KC (corresponding author), Univ Penn, Perelman Sch Med, Dept Psychiat, Ctr Weight & Eating Disorders, 3535 Market St,3rd Floor, Philadelphia, PA 19104 USA.
EM kca@mail.med.upenn.edu
RI Pearl, Rebecca/GRS-0019-2022; Allison, Kelly/O-4174-2019; Tronieri,
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OI Tronieri, Jena/0000-0003-3587-4130; Allison, Kelly/0000-0002-9807-0220
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NR 83
TC 64
Z9 70
U1 1
U2 48
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1523-3812
EI 1535-1645
J9 CURR PSYCHIAT REP
JI Curr. Psychiatry Rep.
PD JUN
PY 2017
VL 19
IS 6
AR 29
DI 10.1007/s11920-017-0784-8
PG 11
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA ET6DF
UT WOS:000400380300001
PM 28439762
DA 2025-06-11
ER

PT J
AU Del Sueldo, M
   Martell-Claros, N
   Zilberman, JM
   Marchegiani, R
   Fernández-Pérez, C
AF Del Sueldo, Mildren
   Martell-Claros, Nieves
   Zilberman, Judith M.
   Marchegiani, Raul
   Fernandez-Perez, Cristina
TI Health perception in menopausa women
SO INTERNATIONAL JOURNAL OF WOMENS HEALTH
LA English
DT Article
DE menopause; health perception; depression; anxiety; metabolic syndrome
ID PERCEIVED HEALTH; FOLLOW-UP; MORTALITY; HYPERTENSION; ASSOCIATION;
   DEPRESSION; RISK
AB Aim: The aim of this study is to find whether the worsening of health perception was related to the menopausal (MNP) state or to its negative consequences on cardiometabolic risk factors (CMRF) and the presence of depression/anxiety.
   Methods: In this study, 2,562 women, 1,357 (53%) MNP and 1,205 (47%) non-MNP, were analyzed. Blood pressure, heart rate, body mass index, waist circumference, and depression/anxiety screening using the Hospital Depression/Anxiety Scale (HADS) were measured. We collected a blood sample in fasting state for glycemia, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol and triglycerides. Logistic regression models were fitted with a backward method from the potentially confusing variables of the menopause study groups.
   Results: Age 49.4 (+/- 15.9) years; 10.1% belonged to semi-rural population; 87.5% had children. Regarding the educational level, 22.1% had <5 years of education, 31.3% had between 6 and 7 years, 33.4% had between 8 and 12 years, and 13.2% had >12 years of education. The prevalence of CMRF was significantly higher in MNP women, except for smoking. We did not find any differences in the prevalence of depression or anxiety between MNP and nonMNP women. Health was perceived as worse among MNP women (P<0.05) and patients over 45 years of age than patients younger than 45 years. We found a relationship between the negative health perception with metabolic syndrome, depression, and anxiety, having children, smoking, residing in rural area, and low educational level; nevertheless, it is not correlative with MNP status.
   Conclusion: Perceived health should be viewed as a multifaceted condition related to social circumstances, and various symptoms in women, including menopause symptoms, but not with MNP state itself.
C1 [Del Sueldo, Mildren; Marchegiani, Raul] Municipalidad Villa Maria, Hlth Heart Program, Cordoba, Argentina.
   [Del Sueldo, Mildren; Marchegiani, Raul] Specialty Clin, Cardiol Div, Cordoba, Argentina.
   [Del Sueldo, Mildren; Marchegiani, Raul] Specialty Clin, Cardiovasc Prevent, Cordoba, Argentina.
   [Martell-Claros, Nieves; Zilberman, Judith M.] Hosp Clin San Carlos, Internal Med Serv, Hypertens Unit, C Martin Lagos S-N, Madrid, Spain.
   [Martell-Claros, Nieves; Zilberman, Judith M.] Univ Complutense Madrid, Sch Med, Madrid, Spain.
   [Martell-Claros, Nieves; Zilberman, Judith M.] San Carlos Clin Hosp, Res Inst, Madrid, Spain.
   [Zilberman, Judith M.] Univ Buenos Aires, IQUIMEFA CONICET, Sch Pharm & Biochem, Physiol Course, Caba, Argentina.
   [Zilberman, Judith M.] Cardiovasc Inst Buenos Aires ICBA, Hypertens Unit, Dept Cardiovasc Prevent, Caba, Argentina.
   [Zilberman, Judith M.] Hosp Gen de Agudos Dr Cosme Argerich, Cardiol Serv, Hypertens Unit, Buenos Aires, DF, Argentina.
   [Fernandez-Perez, Cristina] UCM, San Carlos Clin Hosp, Unit Epidemiol & Clin Methodol, Prevent Med Serv,Res Inst, Madrid, Spain.
C3 Hospital Clinico San Carlos; Complutense University of Madrid;
   University of Buenos Aires; Instituto Cardiovascular de Buenos Aires
   (ICBA); Complutense University of Madrid
RP Martell-Claros, N (corresponding author), Hosp Clin San Carlos, Internal Med Serv, Hypertens Unit, C Martin Lagos S-N, Madrid, Spain.
EM nieves.martell@salud.madrid.org
RI Claros, Nieves/L-4513-2014; Fernandez Perez, Cristina/I-2220-2015
OI Fernandez Perez, Cristina/0000-0001-9853-6257; Del sueldo,
   Mildren/0000-0002-9034-5808
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NR 22
TC 10
Z9 11
U1 0
U2 8
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1179-1411
J9 INT J WOMENS HEALTH
JI Int. J. Womens Health
PY 2018
VL 10
BP 655
EP 661
DI 10.2147/IJWH.S173891
PG 7
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Obstetrics & Gynecology
GA GY0GD
UT WOS:000448192000001
PM 30425587
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Natale, BN
   Manuck, SB
   Shaw, DS
   Matthews, KA
   Muldoon, MF
   Wright, AGC
   Marsland, AL
AF Natale, Brianna N.
   Manuck, Stephen B.
   Shaw, Daniel S.
   Matthews, Karen A.
   Muldoon, Matthew F.
   Wright, Aidan G. C.
   Marsland, Anna L.
TI Systemic Inflammation Contributes to the Association Between Childhood
   Socioeconomic Disadvantage and Midlife Cardiometabolic Risk
SO ANNALS OF BEHAVIORAL MEDICINE
LA English
DT Article
DE Phildhood socioeconomic disadvantage; Inflammation; Cardiometabolic
   health
ID C-REACTIVE PROTEIN; EARLY-LIFE STRESS; ADULT BODY-MASS; METABOLIC
   SYNDROME; ADIPOSE-TISSUE; CARDIOVASCULAR-DISEASE; PSYCHOLOGICAL STRESS;
   BIOLOGICAL RESIDUE; INSULIN-RESISTANCE; SLEEP DURATION
AB Background Childhood socioeconomic disadvantage is associated with increased risk for chronic inflammation and cardiometabolic disease at midlife. Purpose As it is presently unknown whether inflammation mediates the relationship between childhood socioeconomic status (SES) and adulthood cardiometabolic risk, we investigated associations between retrospectively reported childhood SES, circulating levels of inflammatory markers, and a latent construct of cardiometabolic risk in midlife adults. Methods Participants were 1,359 healthy adults aged 30-54 (Adult Health and Behavior I & II; 52% women, 17% Black) who retrospectively reported childhood SES (parental education, occupational grade). Measures included plasma interleukin (IL)-6, C-reactive protein (CRP), and cardiometabolic risk factors. Structural equation modeling was conducted, with cardiometabolic risk modeled as a second-order latent variable with adiposity, blood lipids, glucose control, and blood pressure as first-order components. Results Lower childhood SES was associated with greater risk for cardiometabolic disease at midlife (beta = -0.08, CI[-0.04, -0.01], p = .01) in models adjusted for demographics, but this association was attenuated in models that adjusted for adulthood SES and health behaviors. In fully-adjusted models, the relationship between lower childhood SES and adult cardiometabolic risk was partially explained by higher circulating levels of CRP (beta = -0.05, CI[-0.02, -0.01], p = .001), but not by IL-6. In an exploratory model, lower adulthood SES was also found to independently contribute to the association between childhood SES and adult cardiometabolic risk (beta = -0.02, CI[-0.01, -0.001], p = .02). Conclusions The current study provides initial evidence that systemic inflammation may contribute to childhood socioeconomic disparities in cardiometabolic risk in midlife. Future work would benefit from prospective investigation of these relationships.
C1 [Natale, Brianna N.; Manuck, Stephen B.; Shaw, Daniel S.; Wright, Aidan G. C.; Marsland, Anna L.] Univ Pittsburgh, Dept Psychol, Pittsburgh, PA 15213 USA.
   [Matthews, Karen A.] Univ Pittsburgh, Dept Psychiat, Sch Med, Pittsburgh, PA 15213 USA.
   [Muldoon, Matthew F.] Univ Pittsburgh, Heart & Vasc Inst, Dept Med, Sch Med, Pittsburgh, PA 15213 USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE); University
   of Pittsburgh; Pennsylvania Commonwealth System of Higher Education
   (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of
   Higher Education (PCSHE); University of Pittsburgh
RP Natale, BN (corresponding author), Univ Pittsburgh, Dept Psychol, Pittsburgh, PA 15213 USA.
EM bnn11@pitt.edu
RI Wright, Aidan/W-2821-2019
OI Wright, Aidan/0000-0002-2369-0601
FU NIH [PO1 HL040962, RO1 HL065137, RO1 AG056043, T32 HL007560]
FX This research was supported by the NIH grants PO1 HL040962, RO1
   HL065137, RO1 AG056043, and T32 HL007560.
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NR 74
TC 6
Z9 6
U1 0
U2 6
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0883-6612
EI 1532-4796
J9 ANN BEHAV MED
JI Ann. Behav. Med.
PD JAN 2
PY 2023
VL 57
IS 1
BP 26
EP 37
DI 10.1093/abm/kaac004
EA FEB 2022
PG 12
WC Psychology, Multidisciplinary
WE Social Science Citation Index (SSCI)
SC Psychology
GA 7G2NQ
UT WOS:000759719600001
PM 35195688
OA Green Published
DA 2025-06-11
ER

PT J
AU O'Keefe, EL
   O'Keefe, JH
   Lavie, CJ
AF O'Keefe, Evan L.
   O'Keefe, James H.
   Lavie, Carl J.
TI Exercise Counteracts the Cardiotoxicity of Psychosocial Stress
SO MAYO CLINIC PROCEEDINGS
LA English
DT Review
ID CORONARY-HEART-DISEASE; ACUTE MYOCARDIAL-INFARCTION; PSYCHOLOGICAL
   RISK-FACTORS; CARDIAC REHABILITATION; ARTERY-DISEASE;
   CARDIOVASCULAR-DISEASE; TRAINING-PROGRAMS; METABOLIC SYNDROME;
   PHYSICAL-ACTIVITY; MAJOR DEPRESSION
AB Physical inactivity and psychosocial stress are prevalent in residents of the United States. The purpose of this article is to review the interaction between these 2 conditions and examine the effects of exercise on stress and cardiovascular (CV) health. A query of scientific references between 1974 to 2018 was performed using the PubMed search engine accessing the MEDLINE database using the search terms psychosocial stress, CV disease (CVD), physical activity, exercise, cardiac rehabilitation, and team sports. Psychosocial stress is a strong independent risk factor for adverse CV events. Conversely, people who experience CV events subsequently have drastically elevated rates of new-onset mental health disorders, including depression and anxiety. Psychosocial stress and CVD often trigger self-reinforcing feedback loops that can worsen mental health and cardiac prognosis. Exercise predictably improves CV health and prognosis and also is effective at lowering levels of psychosocial stress. Group exercise in particular seems to provide social support while at the same time boosting fitness levels and, thus, may be the single most important intervention for patients with concomitant CVD and emotional stress. Collaborative physical activity, such as group exercise, team sports, interactive physical play, and cardiac rehabilitation programs, have the potential to improve mental health and CV prognosis. (C) 2019 Mayo Foundation Medical Education and Research.
C1 [O'Keefe, Evan L.; Lavie, Carl J.] Univ Queensland, Sch Med, Ochsner Clin Sch, New Orleans, LA 70121 USA.
   [O'Keefe, James H.] Univ Missouri, Kansas City, MO 64110 USA.
   [O'Keefe, James H.] St Lukes Mid Amer Heart Inst, Kansas City, MO USA.
   [Lavie, Carl J.] John Ochsner Heart & Vasc Inst, Dept Cardiovasc Dis, New Orleans, LA USA.
C3 Ochsner Health System; University of Queensland; University of Missouri
   System; University of Missouri Kansas City; Saint Luke's Mid America
   Heart Institute; Ochsner Health System
RP Lavie, CJ (corresponding author), Univ Queensland, Sch Med, Ochsner Clin Sch, John Ochsner Heart & Vasc Inst,Exercise Labs,Card, 1514 Jefferson Hwy, New Orleans, LA 70121 USA.
EM clavie@ochsner.org
RI Lavie, Carl/A-6014-2011
OI O'Keefe, James/0000-0002-3376-5822
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NR 135
TC 30
Z9 30
U1 2
U2 28
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0025-6196
EI 1942-5546
J9 MAYO CLIN PROC
JI Mayo Clin. Proc.
PD SEP
PY 2019
VL 94
IS 9
BP 1852
EP 1864
DI 10.1016/j.mayocp.2019.02.022
PG 13
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA IU7HB
UT WOS:000483753900027
PM 31451292
OA Bronze
DA 2025-06-11
ER

PT J
AU Brummett, M
   Oglesby, C
   Barkus, S
   Wheelock, NM
   Tate, A
AF Brummett, Mindy
   Oglesby, Chassiti
   Barkus, Sarah
   Wheelock, Nina Meg
   Tate, Allison
TI The importance of education combined with tailored exercise in the
   health and wellness of older adults: a community case study
SO FRONTIERS IN PSYCHOLOGY
LA English
DT Article
DE metabolic syndrome; older adults; physical activity; mental health;
   wellness
ID METABOLIC SYNDROME; LIFE-STYLE; POPULATION
AB Current literature states the importance of mental and physical health in combating the effects of metabolic syndrome; however, there is limited information on whether providing education on the syndrome along with mental and individualized physical exercises improves perceived confidence in the older adult population. A solution to this problem would be to provide a course to this population with a primary goal of education and exercise prescription. A community case study was implemented in the spring of 2024 with the purpose of measuring perceived confidence in metabolic syndrome, management of stress and anxiety, and how to move safely with exercise. Twenty-nine older adults with an average age of 76.1years were recruited from a local senior citizen center. A course was given to the participants that included education and prescription of exercises tailored to the needs of the individual. Before and after the course, participants completed a confidence survey investigating their confidence in lowering the risk for metabolic syndrome, managing stress/anxiety, and understanding how to move safely with exercise. Regarding the post surveys, knowing how to lower the risk of metabolic syndrome increased by 46%, learning how to manage stress and anxiety increased by 50%, and understanding how to exercise safely increased by 41%. The data from this study suggests that providing education along with specific exercise prescription improved the participant's confidence in lowering their risk for metabolic syndrome, management of stress and anxiety, and how to move safely with exercise.
C1 [Brummett, Mindy; Oglesby, Chassiti; Barkus, Sarah; Wheelock, Nina Meg; Tate, Allison] Univ North Texas, Dept Phys Therapy, Hlth Sci Ctr, Ft Worth, TX 76107 USA.
C3 University of North Texas System; University of North Texas Denton
RP Brummett, M (corresponding author), Univ North Texas, Dept Phys Therapy, Hlth Sci Ctr, Ft Worth, TX 76107 USA.
EM mindy.brummett@unthsc.edu
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NR 32
TC 0
Z9 0
U1 1
U2 1
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-1078
J9 FRONT PSYCHOL
JI Front. Psychol.
PD OCT 10
PY 2024
VL 15
AR 1488903
DI 10.3389/fpsyg.2024.1488903
PG 6
WC Psychology, Multidisciplinary
WE Social Science Citation Index (SSCI)
SC Psychology
GA O2N8O
UT WOS:001369569900001
PM 39450129
OA gold
DA 2025-06-11
ER

PT J
AU Bernardes, N
   Ayyappan, P
   De Angelis, K
   Bagchi, A
   Akolkar, G
   Dias, DD
   Belló-Klein, A
   Singal, PK
AF Bernardes, Nathalia
   Ayyappan, Prathapan
   De Angelis, Katia
   Bagchi, Ashim
   Akolkar, Gauri
   Dias, Danielle da Silva
   Bello-Klein, Adriane
   Singal, Pawan K.
TI Excessive consumption of fructose causes cardiometabolic dysfunctions
   through oxidative stress and inflammation
SO CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
LA English
DT Review
DE metabolic syndrome; hypertension; physical activity; inflammation;
   oxidative stress
ID INSULIN-RESISTANCE SYNDROME; NITRIC-OXIDE SYNTHASE; FATTY LIVER-DISEASE;
   SERUM URIC-ACID; SHORT-TERM DIET; METABOLIC SYNDROME; BLOOD-PRESSURE;
   ENDOTHELIAL DYSFUNCTION; EXERCISE INTERVENTION; CARDIOVASCULAR RISK
AB A rapid rise in obesity, as well as physical inactivity, in industrialized countries is associated with fructose-consumption-mediated metabolic syndrome having a strong association with cardiovascular disease. Although insulin resistance is thought to be at the core, visceral obesity, hypertension, and hypertriglyceridemia are also considered important components of this metabolic disorder. In addition, various other abnormalities such as inflammation, oxidative stress, and elevated levels of uric acid are also part of this syndrome. Lifestyle changes through improved physical activity, as well as nutrition, are important approaches to minimize metabolic syndrome and its deleterious effects.
C1 [Bernardes, Nathalia; De Angelis, Katia; Dias, Danielle da Silva] Univ Nove Julho, Diretoria Mestrado, Ctr Posgrad Stricto Sensu, Ave Francisco Matatazzo,612,10 Andar, Barra Funda, SP, Brazil.
   [Ayyappan, Prathapan; Bagchi, Ashim; Akolkar, Gauri; Singal, Pawan K.] Univ Manitoba, Inst Cardiovasc Sci,Rady Fac Hlth Sci, St Boniface Hosp, Albrechtsen Res Ctr,Dept Physiol & Pathophysiol, Winnipeg, MB, Canada.
   [Bello-Klein, Adriane] Univ Fed Rio Grande do Sul, Lab Cardiovasc Physiol, Inst Basic Hlth Sci ICBS, Porto Alegre, RS, Brazil.
C3 Universidade Nove de Julho; University of Manitoba; Saint Boniface
   Hospital; Children's Hospital Research Institute of Manitoba;
   Universidade Federal do Rio Grande do Sul
RP Singal, PK (corresponding author), Univ Manitoba, Inst Cardiovasc Sci,Rady Fac Hlth Sci, St Boniface Hosp, Albrechtsen Res Ctr,Dept Physiol & Pathophysiol, Winnipeg, MB, Canada.
EM psingal@sbrc.ca
RI Bagchi, Ashim/AAY-8074-2020; da Silva Dias, Danielle/AAN-7618-2020;
   Bernardes, Nathalia/L-7460-2015; DE ANGELIS, KATIA/I-6098-2016
OI DE ANGELIS, KATIA/0000-0002-3640-9049
FU Bank of Montreal studentship from the St. Boniface Hospital Foundation;
   St. Boniface Hospital Foundation; Canadian Institutes of Health Research
   (CIHR); Research Manitoba
FX Adriane Bello-Klein was a visiting professor; Nathalia Bernardes and
   Danielle da Silva Dias were exchange students from Brazil under the
   Canada-Brazil Training Program (CAPES-DFATD). Gauri Akolkar is the
   recipient of the Bank of Montreal studentship from the St. Boniface
   Hospital Foundation. Pawan K. Singal is the holder of the Dr. Naranjan
   S. Dhalla Chair in Cardiovascular Research supported by the St. Boniface
   Hospital Foundation. This work was supported by Canadian Institutes of
   Health Research (CIHR) and Research Manitoba.
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NR 211
TC 15
Z9 17
U1 0
U2 15
PU CANADIAN SCIENCE PUBLISHING
PI OTTAWA
PA 65 AURIGA DR, SUITE 203, OTTAWA, ON K2E 7W6, CANADA
SN 0008-4212
EI 1205-7541
J9 CAN J PHYSIOL PHARM
JI Can. J. Physiol. Pharmacol.
PD OCT
PY 2017
VL 95
IS 10
BP 1078
EP 1090
DI 10.1139/cjpp-2016-0663
PN 2
PG 13
WC Pharmacology & Pharmacy; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Physiology
GA FI3VM
UT WOS:000411898100002
PM 28187269
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Saintila, J
   Oblitas-Guerrero, SM
   Larrain-Tavara, G
   Lizarraga-De-Maguina, IG
   Bernal-Corrales, FD
   López-López, E
   Calizaya-Milla, YE
   Serpa-Barrientos, A
   Ramos-Vera, C
AF Saintila, Jacksaint
   Oblitas-Guerrero, Susan M.
   Larrain-Tavara, Giovanna
   Lizarraga-De-Maguina, Isabel G.
   Bernal-Corrales, Fatima del Carmen
   Lopez-Lopez, Elmer
   Calizaya-Milla, Yaquelin E.
   Serpa-Barrientos, Antonio
   Ramos-Vera, Cristian
TI Associations between social network addiction, anxiety symptoms, and
   risk of metabolic syndrome in Peruvian adolescents-a cross-sectional
   study
SO FRONTIERS IN PUBLIC HEALTH
LA English
DT Article
DE adolescents; anxiety symptoms; cardiometabolic risk; metabolic syndrome;
   obesity; social network addiction
ID TO-HEIGHT RATIO; WAIST CIRCUMFERENCE; CHILDREN; DISORDERS; QUALITY;
   OBESITY; GAD-2
AB Background The link between physical and mental health and screen time in adolescents has been the subject of scientific scrutiny in recent years. However, there are few studies that have evaluated the association between social network addiction (SNA) and metabolic risk in this population. Objective This study determined the association between SNA and anxiety symptoms with the risk of metabolic syndrome (MetS) in adolescents. Methods A cross-sectional study was conducted in Peruvian adolescents aged 12 to 18 years, who completed a Social Network Addiction Questionnaire and the Generalized Anxiety Disorder 2-item scale (GAD-2), between September and November 2022. A total of 903 participants were included in the study using a non-probability convenience sample. Sociodemographic and anthropometric data were also collected. Binary logistic regression was used to explore the association between SNA and anxiety symptoms with MetS in a cross-sectional analysis. Results Males were more likely to have MetS than females (OR = 1.133, p = 0.028). Participants who were 16 years of age or older and those with excess body weight were 2.166, p = 0.013 and 19.414, p < 0.001 times more likely to have MetS, respectively. Additionally, SNA (OR = 1.517, p = 0.016) and the presence of anxiety symptoms (OR = 2.596, p < 0.001) were associated with MetS. Conclusion Our findings suggest associations between SNA, anxiety symptoms, and MetS among youth. However, more studies are needed to better understand this association and to deepen the possible clinical and public health implications.
C1 [Saintila, Jacksaint; Lopez-Lopez, Elmer] Univ Senor Sipan, Escuela Med Humana, Chiclayo, Peru.
   [Oblitas-Guerrero, Susan M.; Larrain-Tavara, Giovanna; Lizarraga-De-Maguina, Isabel G.; Bernal-Corrales, Fatima del Carmen] Univ Senor Sipan, Escuela Enfermeria, Chiclayo, Peru.
   [Calizaya-Milla, Yaquelin E.] Univ Peruana Union, Res Grp Nutr & Lifestyle, Lima, Peru.
   [Serpa-Barrientos, Antonio] Univ Nacl Mayor San Marcos, Dept Psicol, Lima, Peru.
   [Ramos-Vera, Cristian] Univ Cesar Vallejo UCV, Area Invest, Lima, Peru.
C3 Universidad Senor de Sipan; Universidad Senor de Sipan; Universidad
   Peruana Union; Universidad Nacional Mayor de San Marcos
RP Saintila, J (corresponding author), Univ Senor Sipan, Escuela Med Humana, Chiclayo, Peru.; Calizaya-Milla, YE (corresponding author), Univ Peruana Union, Res Grp Nutr & Lifestyle, Lima, Peru.
EM jacksaintsaintila@gmail.com; yaquelincalizaya@upeu.edu.pe
RI CALIZAYA-MILLA, YAQUELIN/AAH-9427-2021; Serpa-Barrientos,
   Antonio/AAW-4534-2021; ramos, cristian/HIA-0411-2022; Saintila,
   Jacksaint/ABF-6510-2020; Bernal Corrales, Fatima/ACN-7229-2022; Oblitas
   Guerrero, Susan Miriam/AHC-0367-2022
OI Bernal Corrales, Fatima Del Carmen/0000-0002-0930-1403; Oblitas
   Guerrero, Susan Miriam/0000-0003-1651-7584
FU Universidad Seor de Sipn through the Vice Rectorate for Research
   [082-2022-PD-USS, degrees 079-2022-PD-USS]
FX The author(s) declare financial support was received for the research,
   authorship, and/or publication of this article. The study was financed
   by the Universidad Senor de Sipan through the Vice Rectorate for
   Research, Grant: 082-2022-PD-USS and approved by RESOLUCI & Oacute;N DE
   DIRECTORIO N degrees 079-2022-PD-USS.r The author(s) declare financial
   support was received for the research, authorship, and/or publication of
   this article. The study was financed by the Universidad Senor de Sipan
   through the Vice Rectorate for Research, Grant: 082-2022-PD-USS and
   approved by RESOLUCI & Oacute;N DE DIRECTORIO N degrees 079-2022-PD-USS.
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NR 65
TC 1
Z9 1
U1 5
U2 12
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 2296-2565
J9 FRONT PUBLIC HEALTH
JI Front. Public Health
PD MAY 1
PY 2024
VL 12
AR 1261133
DI 10.3389/fpubh.2024.1261133
PG 9
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA QR6E5
UT WOS:001222628800001
PM 38751589
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Carroll, D
   Phillips, AC
   Thomas, GN
   Gale, CR
   Deary, I
   Batty, GD
AF Carroll, Douglas
   Phillips, Anna C.
   Thomas, G. Neil
   Gale, Catharine R.
   Deary, Ian
   Batty, G. David
TI Generalized Anxiety Disorder Is Associated with Metabolic Syndrome in
   the Vietnam Experience Study
SO BIOLOGICAL PSYCHIATRY
LA English
DT Article
DE Generalized anxiety disorder; major depressive disorder; metabolic
   syndrome; veterans
ID DEPRESSIVE SYMPTOMS; YOUNG-ADULTS; RISK; HEALTH; WOMEN
AB Background: Few studies have explored the relationship between major mental health disorders and metabolic syndrome (MetS), although both have been linked to cardiovascular disease. The present study examined the cross-sectional associations of major depressive disorder (MDD) and generalized anxiety disorder (GAD) with MetS in a large study of male US veterans.
   Methods: The analyses were cross-sectional. Participants (n = 4256) were drawn from the Vietnam Experience Study. From military service files, telephone interviews, and a medical examination, occupational, socio-demographic, and health data were collected. One-year prevalence of MDD and GAD was determined with DSM-III criteria. Metabolic syndrome was ascertained from data on: body mass index, fasting blood glucose or a diagnosis of diabetes, blood pressure, high-density lipoprotein cholesterol, and triglyceride levels.
   Results: In models that adjusted for age (p = .01) and additionally for place of service, ethnicity, marital status, smoking, alcohol consumption, IQ at enlistment, household income in midlife, and education grade achieved (p = .02), GAD was positively associated with MetS. Major depressive disorder was not related to MetS.
   Conclusions: Depression has very much been the focal condition for studies on mental health and physical health outcomes. The current data suggest that future research should perhaps pay equal attention to GAD.
C1 [Carroll, Douglas; Phillips, Anna C.] Univ Birmingham, Sch Sport, Birmingham B15 2TT, W Midlands, England.
   [Thomas, G. Neil] Univ Birmingham, Sch Med & Dent Sci, Birmingham B15 2TT, W Midlands, England.
   [Gale, Catharine R.] Univ Southampton, Resource Ctr, Southampton SO9 5NH, Hants, England.
   [Deary, Ian; Batty, G. David] Univ Edinburgh, Dept Psychol, Ctr Cognit Ageing & Cognit Epidemiol, MRC, Edinburgh, Midlothian, Scotland.
   [Batty, G. David] Univ Glasgow, Social & Publ Hlth Sci Unit, MRC, Glasgow, Lanark, Scotland.
C3 University of Birmingham; University of Birmingham; University of
   Southampton; University of Edinburgh; MRC/CSO SOCIAL AND PUBLIC HEALTH
   SCIENCES UNIT; University of Glasgow
RP Carroll, D (corresponding author), Univ Birmingham, Sch Sport, Birmingham B15 2TT, W Midlands, England.
EM carrolld@bham.ac.uk
RI Thomas, G./A-1879-2013; Gale, Catharine/B-1653-2012; Batty,
   GD/Y-4401-2018; Deary, Ian/C-6297-2009; Whittaker, Anna/A-3577-2013
OI Deary, Ian/0000-0002-1733-263X; Batty, George/0000-0003-1822-5753;
   Thomas, Graham Neil/0000-0002-2777-1847; Gale,
   Catharine/0000-0002-3361-8638; Whittaker, Anna/0000-0002-5461-0598
FU MRC [MC_U130059821, G0700704] Funding Source: UKRI; Biotechnology and
   Biological Sciences Research Council Funding Source: Medline; Medical
   Research Council [MC_U130059821, G0700704] Funding Source: Medline;
   Wellcome Trust [U.1300.00.006.00012.01] Funding Source: Medline
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NR 19
TC 84
Z9 91
U1 0
U2 5
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0006-3223
EI 1873-2402
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD JUL 1
PY 2009
VL 66
IS 1
BP 91
EP 93
DI 10.1016/j.biopsych.2009.02.020
PG 3
WC Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA 463YK
UT WOS:000267469900014
PM 19344891
OA Green Submitted, Green Accepted
DA 2025-06-11
ER

PT J
AU Kuperberg, M
   Köhler-Forsberg, O
   Shannon, AP
   George, N
   Greenebaum, S
   Bowden, CL
   Calabrese, JR
   Thase, M
   Shelton, RC
   McInnis, M
   Deckersbach, T
   Tohen, M
   Kocsis, JH
   Ketter, TA
   Friedman, ES
   Iosifescu, D
   Ostacher, MJ
   Sylvia, LG
   McElroy, SL
   Nierenberg, AA
AF Kuperberg, Maya
   Kohler-Forsberg, Ole
   Shannon, Alec P.
   George, Nevita
   Greenebaum, Sophie
   Bowden, Charles L.
   Calabrese, Joseph R.
   Thase, Michael
   Shelton, Richard C.
   McInnis, Melvin
   Deckersbach, Thilo
   Tohen, Mauricio
   Kocsis, James H.
   Ketter, Terence A.
   Friedman, Edward S.
   Iosifescu, Dan, V
   Ostacher, Michael J.
   Sylvia, Louisa G.
   McElroy, Susan L.
   Nierenberg, Andrew A.
TI Cardiometabolic risk markers during mood-stabilizing treatment:
   Correlation with drug-specific effects, depressive symptoms and
   treatment response
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Bipolar disorder; Cardiometabolic risk; Quetiapine; Lithium;
   Cardiovascular disease; Metabolic syndrome
ID MODERATE-DOSE-USE; BIPOLAR DISORDER; METABOLIC SYNDROME; MORTALITY;
   TRIAL; METAANALYSIS; LITHIUM; SCALE; 1ST-EPISODE; ASSOCIATION
AB Background: Patients with bipolar disorder have higher rates of cardiometabolic comorbidities and mortality. Although guidelines emphasize the importance of cardiovascular monitoring, few studies characterized the cardiometabolic risk profile during treatment and their relation to symptomatology and treatment response. Methods: We analyzed data from two similar 24-weeks comparative effectiveness trials, with a combined sample of 770 participants randomized to two different lithium doses, quetiapine (300 mg/day), or standard treatment without lithium. Glucose, lipids and vital signs were measured before and after 24 weeks of treatment. We calculated several cardiovascular risk scores, assessed baseline correlations and compared the four treatment arms via multiple linear regression models. Results: Higher cholesterol and LDL levels were associated with greater depression severity, showing differential correlations to specific symptoms, particularly agitation, low energy and suicidality. Those randomized to quetiapine showed a significant worsening of cardiometabolic markers during the 24-week trial. Neither baseline nor change in lipid levels correlated with differential treatment response. Limitations: Study duration was short from the perspective of cardiometabolic risk markers, and all treatment arms included patients taking adjunct antipsychotics. The trials compared quetiapine to lithium, but not to other medications known to affect similar risk factors. Conclusions: Treatment with 300 mg/day quetiapine for 24 weeks, representing a short and common dose course, resulted in increased cardiometabolic risk markers, emphasizing the importance of monitoring during mood-stabilizing treatment. The symptom-specific associations are in line with previous studies in unipolar depression, suggesting a cardiometabolic-depression link that needs to be further studied in bipolar depression.
C1 [Kuperberg, Maya; Kohler-Forsberg, Ole; Shannon, Alec P.; George, Nevita; Greenebaum, Sophie; Deckersbach, Thilo; Iosifescu, Dan, V; Ostacher, Michael J.; Sylvia, Louisa G.; Nierenberg, Andrew A.] Massachusetts Gen Hosp, Dept Psychiat, Boston, MA 02114 USA.
   [Kuperberg, Maya; Kohler-Forsberg, Ole; Shannon, Alec P.; George, Nevita; Greenebaum, Sophie; Deckersbach, Thilo; Sylvia, Louisa G.; Nierenberg, Andrew A.] Harvard Med Sch, Boston, MA 02115 USA.
   [Kohler-Forsberg, Ole] Aarhus Univ, Aarhus Univ Hosp, Dept Clin Med, Psychosis Res Unit,Psychiat, Aarhus, Denmark.
   [Bowden, Charles L.] Univ Texas Hlth Sci Ctr San Antonio, Dept Psychiat, San Antonio, TX 78229 USA.
   [Calabrese, Joseph R.] Case Western Reserve Univ, Dept Psychiat, Cleveland, OH 44106 USA.
   [Thase, Michael] Univ Penn, Dept Psychiat, Philadelphia, PA 19104 USA.
   [Shelton, Richard C.] Univ Alabama Birmingham, Dept Psychiat, Birmingham, AL USA.
   [McInnis, Melvin] Univ Michigan, Dept Psychiat, Ann Arbor, MI 48109 USA.
   [Tohen, Mauricio] Univ New Mexico, Hlth Sci Ctr, Dept Psychiat, Albuquerque, NM 87131 USA.
   [Kocsis, James H.] Weill Cornell Med Coll, Dept Psychiat, New York, NY USA.
   [Ketter, Terence A.] Stanford Univ, Sch Med, Dept Psychiat & Behav Sci, Stanford, CA USA.
   [Friedman, Edward S.] Univ Pittsburgh, Med Ctr, Dept Psychiat, Pittsburgh, PA USA.
   [McElroy, Susan L.] Univ Cincinnati, Coll Med, Dept Psychiat & Behav Neurosci, Cincinnati, OH USA.
   [McElroy, Susan L.] Univ Cincinnati, Coll Med, Lindner Ctr Hope, Cincinnati, OH USA.
   [Kuperberg, Maya] Beer Yaakov Mental Hlth Ctr, 1 Rabin Ave, Beer Yaagov, Israel.
C3 Harvard University; Harvard University Medical Affiliates; Massachusetts
   General Hospital; Harvard University; Harvard Medical School; Aarhus
   University; University of Texas System; University of Texas Health
   Science Center at San Antonio; University System of Ohio; Case Western
   Reserve University; University of Pennsylvania; University of Alabama
   System; University of Alabama Birmingham; University of Michigan System;
   University of Michigan; University of New Mexico's Health Sciences
   Center; University of New Mexico; Cornell University; Weill Cornell
   Medicine; Stanford University; Pennsylvania Commonwealth System of
   Higher Education (PCSHE); University of Pittsburgh; University System of
   Ohio; University of Cincinnati; University System of Ohio; University of
   Cincinnati; Tel Aviv University
RP Kuperberg, M (corresponding author), Massachusetts Gen Hosp, Dept Psychiat, Boston, MA 02114 USA.
EM Mayakuperberg@moh.health.gov.il
RI Nierenberg, ANierenberg/IAR-5549-2023; Shannon, Alec/AAG-2558-2021;
   Shelton, Richard/AAC-4137-2022; McInnis, Melvin/F-6963-2012; Ostacher,
   Michael/AFK-7519-2022; Sylvia, Louisa/AAE-8027-2022; Iosifescu,
   Dan/L-3305-2019
OI Ostacher, Michael/0000-0003-0353-7535; Shannon, Alec/0000-0001-7094-4953
FU Agency for Healthcare Research and Quality [1R01HS019371-01]; National
   Institute of Mental Health [N01MH80001]
FX Bipolar CHOICE was funded by the Agency for Healthcare Research and
   Quality [1R01HS019371-01] . LiTMUS was funded by the National Institute
   of Mental Health [N01MH80001] . Funding sources were not involved in
   current analysis, interpretation, writing or submission of this article.
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NR 38
TC 8
Z9 8
U1 1
U2 4
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD MAR 1
PY 2022
VL 300
BP 41
EP 49
DI 10.1016/j.jad.2021.12.047
EA DEC 2021
PG 9
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA YD3PY
UT WOS:000740323500006
PM 34952123
DA 2025-06-11
ER

PT J
AU Reini, SA
AF Reini, Seth A.
TI Hypercortisolism as a Potential Concern for Submariners
SO AVIATION SPACE AND ENVIRONMENTAL MEDICINE
LA English
DT Review
DE cortisol metabolic syndrome exercise depression fatigue sleep
ID PITUITARY-ADRENAL AXIS; METABOLIC SYNDROME; PHYSICAL-EXERCISE;
   CUSHINGS-SYNDROME; CHRONIC STRESS; ENDOGENOUS-DEPRESSION; PSYCHOSOCIAL
   FACTORS; CORTISOL SECRETION; NEUROPEPTIDE-Y; RISK-FACTOR
AB Cortisol is stress-response hormone that is important for survivability in fight or flight situations Hypercortisolism is a state of chronically elevated cortisol levels due to a failure to return to, or maintain baseline levels It is a condition that is often undiagnosed and can aid in the development of many physiological and psychological health problems Some of the health ailments associated with hypercortisolism include metabolic syndrome decreases in bone mineral density and depression Chronic stress and sleep deprivation are two common causes of hypercortisolism both areas of concern within the submarine community This review discusses the etiology of hypercortisolism and the likelihood of submariner vulnerability to the condition along with health problems associated with it Lastly, strategies to prevent chronic elevation of cortisol and mitigate the potential health ricks associated with the condition are covered
C1 Naval Submarine Med Res Lab, Warfighter Performance Dept, Groton, CT 06349 USA.
RP Reini, SA (corresponding author), Naval Submarine Med Res Lab, Warfighter Performance Dept, Naval Submarine Base New London Box 900, Groton, CT 06349 USA.
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NR 101
TC 7
Z9 9
U1 0
U2 16
PU AEROSPACE MEDICAL ASSOC
PI ALEXANDRIA
PA 320 S HENRY ST, ALEXANDRIA, VA 22314-3579 USA
SN 0095-6562
EI 1943-4448
J9 AVIAT SPACE ENVIR MD
JI Aviat. Space Environ. Med.
PD DEC
PY 2010
VL 81
IS 12
BP 1114
EP 1122
DI 10.3357/ASEM.2875.2010
PG 9
WC Public, Environmental & Occupational Health; Medicine, General &
   Internal; Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health; General & Internal
   Medicine; Sport Sciences
GA 690EF
UT WOS:000284984600007
PM 21197856
DA 2025-06-11
ER

PT J
AU Fuenmayor, MAG
   Guerra, LMZ
   Sánchez, LAR
   Manotoa, AMZ
   Llamuca, JVS
   Pailiacho, MCZ
   Fuenmayor, AGG
   Lliguín, CEL
   Bonilla, EBS
AF Gonzalez Fuenmayor, Marco Antonio
   Zumba Guerra, Liveth Monserrath
   Robayo Sanchez, Luis Andres
   Zhicay Manotoa, Angelica Maria
   Sanchez Llamuca, Jenny Viviana
   Zuniga Pailiacho, Monica Carolina
   Gonzalez Fuenmayor, Andrea Gabriela
   LLangari Lliguin, Carolina Estefania
   Sanchez Bonilla, Estefania Belen
TI Approach to the metabolic syndrome in psychiatric patients
SO REVISTA LATINOAMERICANA DE HIPERTENSION
LA English
DT Article
DE Metabolic syndrome; cardiovascular disease; type 2 diabetes mellitus;
   mental disorders; depression
ID AUTONOMIC NERVOUS-SYSTEM; NF-KAPPA-B; RISK; DEPRESSION; DISORDERS;
   STRESS; LEPTIN; MODULATION; MECHANISMS; CORTISOL
AB The metabolic syndrome (MS) is a pathologic condition characterized by the coexistence of abdominal obesity, insulin resistance, hypertension, and hyperlipidemia, accompanied by endothelial dysfunction, chronic inflammation, hypercoagulability states, and adiposopathy. This conglomerate is related with an increase in the risk of cardiovascular disease, type 2 diabetes mellitus, and other chronic non-communicable diseases of high prevalence, morbidity, and mortality. Patients with mental disorders have also been demonstrated to exhibit a greater risk for these cardiometabolic disturbances, especially those with depression. Although historically these problems were prominently attributed to atypical antipsychotics, patients with mental disorders who do not receive these drugs also display higher than average cardiometabolic risk. The pathophysiologic phenomena implicated encompass numerous neurohumoral alterations with a severe metabolic impact, particularly through the hypothalamic-pituitary-adrenal axis, and the sympathetic nervous system. This review exposes the mechanisms possibly involved in the relationship between MS and mental disorders, with an emphasis on depression.
C1 [Gonzalez Fuenmayor, Marco Antonio] Hosp Gen San Juan, Quito, Ecuador.
   [Zumba Guerra, Liveth Monserrath; Zhicay Manotoa, Angelica Maria; Sanchez Llamuca, Jenny Viviana] Hosp Jose Maria Velasco Ibarra, Tena, Ecuador.
   [Robayo Sanchez, Luis Andres] Hosp Gen Puyo, Puyo, Ecuador.
   [Zuniga Pailiacho, Monica Carolina] Inst Ecuatoriano Seguridad Social, Quito, Ecuador.
   [Gonzalez Fuenmayor, Andrea Gabriela] Hosp Gen Andino, Riobamba Canton, Ecuador.
   [LLangari Lliguin, Carolina Estefania] Hosp Gen Riobamba, Riobamba, Ecuador.
   [Sanchez Bonilla, Estefania Belen] Hosp Gen Ambato IESS, Ambato, Ecuador.
RP Fuenmayor, MAG (corresponding author), Hosp Gen San Juan, Quito, Ecuador.
EM marcogonzalezfuenmayor@gmail.com
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NR 51
TC 0
Z9 0
U1 0
U2 1
PU SOC LATINOAMERICANA HIPERTENSION
PI SAN JOSE
PA ESCUELA  MEDICINA JOSE MARIA VARGAS, CATEDRA FARMACOLOGIA, PISO 3
   ESQ-PIRINEOUS, SAN JOSE, 00000, VENEZUELA
SN 1856-4550
J9 REV LATINOAM HIPERTE
JI Rev. Latinoam. Hipertens.
PY 2021
VL 16
IS 2
BP 157
EP +
DI 10.5281/zenodo.5513594
PG 8
WC Peripheral Vascular Disease
WE Emerging Sources Citation Index (ESCI)
SC Cardiovascular System & Cardiology
GA XZ4LP
UT WOS:000737625100008
DA 2025-06-11
ER

PT J
AU Gopal, N
   Pune, AS
   Takhelmayum, R
   Ahirwar, AK
AF Gopal, Niranjan
   Pune, Akash Shivaji
   Takhelmayum, Roshan
   Ahirwar, Ashok Kumar
TI Does serum TSH level act as a surrogate marker for psychological stress
   and cardio-metabolic risk among adolescent and young people?
SO HORMONE MOLECULAR BIOLOGY AND CLINICAL INVESTIGATION
LA English
DT Article
DE adolescent; cardio-metabolic risk; psychological stress; Thyroid
   Stimulating Hormone (TSH); young people
ID INSULIN-RESISTANCE; THYROID-FUNCTION; THYROTROPIN LEVELS; ON-CALL;
   ASSOCIATION; HORMONES
AB Objectives: The incidence of metabolic syndrome is increasing even at younger ages. Metabolic syndrome constitutes a group of cardiovascular risk factors that include high cholesterol, triacylglycerol, hyperglycemia, central obesity, etc., which increases the risk of cardiovascular disease, diabetes mellitus, may be even cancer. Indian students enter colleges just after crossing their adolescent age and will be exposed to greater academic stress. Psychological stress or depression is associated with transient change in thyroid hormones level or dysfunction. To explore an association among serum Thyroid Stimulating Hormone (TSH) levels, fT3:fT4 ratio, psychological stress scores, and selected known cardio-metabolic risk markers.
   Methods: Forty first year MBBS students were included. Their demographic, anthropometric variables, and the blood pressure were documented. Serum TSH, fT3, fT4, and salivary cortisol level was quantified. The stress level was assessed using Cohen Perceived Stress Scale Scoring. Data were expressed in mean +/- standard deviation. Data (parametric/non-parametric) were compared by Independent unpaired ANOVA or Kruskal Wallis test whichever is appropriate. Spearmen correlation analysis was performed.
   Results: Serum TSH and Cohen stress score are negatively correlated (r=-0.152), but serum cortisol showed (r=0.763) a positive correlation. TSH levels and the marks obtained in the summative assessments were negatively correlated and the correlation was not statistically significant.
   Conclusions: The psychological stress is associated with low serum TSH, high cortisol, and poor academic performance in first year MBBS students. Blood pressure, plasma glucose, and anthropometric measures were not associated with the psychological stress.
C1 [Gopal, Niranjan; Pune, Akash Shivaji; Takhelmayum, Roshan; Ahirwar, Ashok Kumar] All India Inst Med Sci, Dept Biochem, Plot 2,Sect 20, Nagpur, Maharashtra, India.
C3 All India Institute of Medical Sciences (AIIMS) Nagpur
RP Gopal, N (corresponding author), All India Inst Med Sci, Dept Biochem, Plot 2,Sect 20, Nagpur, Maharashtra, India.
EM gopal.niranjan@gmail.com
FU Indian Council of Medical Research (ICMR) [2019-05726]
FX The authors acknowledge Indian Council of Medical Research (ICMR) for
   the awarding Short Term Studentship (STS) to Mr. Akash Shivaji Pune,
   Student (ICMR-STS REFERNCE ID: 2019-05726), MBBS Phase II, under the
   guidance of Dr. Niranjan Gopal.
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NR 32
TC 2
Z9 2
U1 2
U2 5
PU WALTER DE GRUYTER GMBH
PI BERLIN
PA GENTHINER STRASSE 13, D-10785 BERLIN, GERMANY
SN 1868-1883
EI 1868-1891
J9 HORM MOL BIOL CLIN I
JI Horm. Mol. Biol. Clin. Investig.
PD MAR 3
PY 2022
VL 43
IS 1
BP 41
EP 46
DI 10.1515/hmbci-2021-0021
EA SEP 2021
PG 6
WC Biochemistry & Molecular Biology
WE Emerging Sources Citation Index (ESCI)
SC Biochemistry & Molecular Biology
GA ZS4PD
UT WOS:000738165100001
PM 34525272
DA 2025-06-11
ER

PT J
AU Goldbacher, EM
   Matthews, KA
AF Goldbacher, Edie M.
   Matthews, Karen A.
TI Are psychological characteristics related to risk of the metabolic
   syndrome? A review of the literature
SO ANNALS OF BEHAVIORAL MEDICINE
LA English
DT Review
ID INSULIN-INDUCED HYPOGLYCEMIA; LIFE-STYLE INTERVENTION; VISCERAL
   ADIPOSE-TISSUE; CORONARY-HEART-DISEASE; BODY-FAT DISTRIBUTION; 3RD
   NATIONAL-HEALTH; MIDDLE-AGED WOMEN; DEPRESSIVE SYMPTOMS; YOUNG-ADULTS;
   CARDIOVASCULAR RISK
AB Background: We evaluate the evidence that depression, anger, hostility, and anxiety are related to risk for the metabolic syndrome, focusing as well on its components of central adiposity and insulin resistance. In addition, we identify possible moderators of these associations and summarize plausible underlying biobehavioral pathways. Methods: Medline, PsycINFO, PubMed, and Web of Science searches were conducted using the keywords metabolic syndrome, syndrome x, central adiposity/obesity, visceral adiposity/obesity, body fat distribution, waist circumference, waist hip ratio, insulin resistance/sensitivity, glucose tolerance, psychological, depression, hostility, anger, cynicism, and anxiety. Results: The current literature provides cross-sectional evidence for an association between psychological characteristics and the metabolic syndrome. Prospective data, though limited, suggest that depression, hostility, and anger predict increased risk for the metabolic syndrome. Data on modifiers are too limited to permit definitive conclusions. Negative health behaviors and hypothalamic and sympathetic dysregulation are identified as plausible underlying pathways. Conclusions: More prospective studies, conducted with diverse samples, are needed to delineate the direction of this relationship and the proposed biobehavioral mechanisms; experimental investigations are needed to test for causality. Nevertheless, findings suggest that psychological characteristics, especially depression, hostility, and anger, may increase risk for the metabolic syndrome, providing a novel direction for prevention and treatment interventions.
C1 Univ Pittsburgh, Dept Psychiat, Pittsburgh, PA 15213 USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE); University
   of Pittsburgh
RP Matthews, KA (corresponding author), Univ Pittsburgh, Dept Psychiat, 3811 Ohara St, Pittsburgh, PA 15213 USA.
EM matthewska@upmc.edu
FU NHLBI NIH HHS [HL07560, HL076858, HL076852] Funding Source: Medline
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NR 104
TC 138
Z9 158
U1 0
U2 14
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0883-6612
EI 1532-4796
J9 ANN BEHAV MED
JI Ann. Behav. Med.
PY 2007
VL 34
IS 3
BP 240
EP 252
DI 10.1007/BF02874549
PG 13
WC Psychology, Multidisciplinary
WE Social Science Citation Index (SSCI)
SC Psychology
GA 238UW
UT WOS:000251474200002
PM 18020934
DA 2025-06-11
ER

PT J
AU Son, E
   Kwon, KH
AF Son, Eunhye
   Kwon, Ki Han
TI Dance/exercise impact for adults with mental health disorders: a
   systematic review
SO BODY MOVEMENT AND DANCE IN PSYCHOTHERAPY
LA English
DT Review
DE Dance therapy; mental health disorder; health promotion; physical
   activity; exercise intervention
ID DANCE MOVEMENT THERAPY; DANCE/MOVEMENT THERAPY; PHYSICAL-ACTIVITY;
   INTELLECTUAL DISABILITIES; BODY PSYCHOTHERAPY; METABOLIC SYNDROME;
   BIPOLAR DISORDER; INTERVENTIONS; DEPRESSION; DEMENTIA
AB This paper investigated the effect of dance and exercise on the health promotion of adults with mental health disorders. As mental health is a social issue, the characteristics of physical movement through dance and exercise were reviewed to find ways to effectively approach mental health services and treatment. Based on existing papers, a systematic review was conducted using Web of Science, Google Scholar, and Scopus to comprehensively investigate and organise the correlation between physical movement and mental health, the characteristics of dance therapy, and psychotherapy of exercise. Studies have shown that dance and exercise therapy helps reduce side effects, relieve depression and anxiety from actual antipsychotics, and helps to recognise one's problems and increase the willingness to treat them. New therapy development according to the online era and limitations according to difficulty need to be addressed.
C1 [Son, Eunhye] Sungshin Womens Univ, Grad Sch, Dept Beauty Ind, Seoul, South Korea.
   [Kwon, Ki Han] Kookmin Univ, Coll Gen Educ, Seoul, South Korea.
C3 Sungshin Women's University; Kookmin University
RP Kwon, KH (corresponding author), Kookmin Univ, Coll Gen Educ, Seoul, South Korea.
EM kihan.kwon@kookmin.ac.kr
RI Son, Eunhye/KVB-5644-2024
OI SON, Eunhye/0000-0003-1660-8806
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NR 67
TC 0
Z9 0
U1 10
U2 33
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 1743-2979
EI 1743-2987
J9 BODY MOV DANCE PSYCH
JI Body Mov. Dance Psychother.
PD JUL 2
PY 2024
VL 19
IS 3
BP 250
EP 267
DI 10.1080/17432979.2024.2308625
EA FEB 2024
PG 18
WC Psychology, Clinical
WE Emerging Sources Citation Index (ESCI)
SC Psychology
GA A2C6F
UT WOS:001162340800001
DA 2025-06-11
ER

PT J
AU Byeon, WJ
   Lee, SJ
   Khil, TG
   Jeong, AY
   Han, BD
   Sohn, MS
   Choi, JW
   Kim, YH
AF Byeon, Woo-Jin
   Lee, Sung-Jae
   Khil, Tae-Gyu
   Jeong, Ah-Young
   Han, Byoung-Duck
   Sohn, Min-Sung
   Choi, Jae-Wook
   Kim, Yang-Hyun
TI Association between a Marine Healing Program and Metabolic Syndrome
   Components and Mental Health Indicators
SO MEDICINA-LITHUANIA
LA English
DT Article
DE metabolic syndrome; Korean; marine healing program; efficacy
ID CARDIOVASCULAR RISK-FACTORS; GAMMA-GLUTAMYL-TRANSFERASE;
   PHYSICAL-ACTIVITY; WEIGHT-GAIN; INTERVENTION; CHOLESTEROL; BENEFITS;
   INDIVIDUALS; PREVENTION; MORTALITY
AB Background and Objectives: Metabolic syndrome is a growing health concern globally, and its prevalence continues to increase. This study investigated whether a marine healing program could improve metabolic syndrome indicators and mental health in adults with a metabolic syndrome and those at risk of developing it. Materials and Methods: This study enrolled 30 participants who were assigned to either the experimental or control groups. The duration of the study was set at 4 weeks. Both groups received metabolic syndrome management education, and the experimental group additionally participated in two marine healing programs. Anthropometric indicators, biochemical indicators, and mental health indicators were collected before and after the intervention. Results: The findings indicate that the experimental group had significantly lower systolic blood pressure, triglycerides, and body weight, as well as higher levels of high-density lipoprotein (HDL-C) and uric acid. Mental health indicators (Hospital Anxiety and Depression Scale and quality of life measures) additionally showed improvement. Pre-post comparisons between the experimental group and the control group showed that the experimental group had significantly decreased by 1.05 kg in body weight, whereas the control group increased by 0.29 kg in body weight. In addition, HDL-C decreased by 0.91 mg/dL in the control group and increased by 3.7 mg/dL in the experimental group. Conclusions: Overall, these results suggest that marine healing programs could improve metabolic syndrome indicators such as body weight and HDL-C better than the control treatment.
C1 [Byeon, Woo-Jin] Korea Univ, Grad Sch, Dept Publ Hlth, 73 Goryeodae-ro, Seoul 02841, South Korea.
   [Lee, Sung-Jae; Khil, Tae-Gyu; Jeong, Ah-Young] Korea Univ, Coll Med, Dept Integrat Med, 73 Goryeodae ro, Seoul 02841, South Korea.
   [Han, Byoung-Duck; Kim, Yang-Hyun] Korea Univ, Coll Med, Dept Family Med, Anam Hosp, 73 Goryeodae ro, Seoul 02841, South Sudan.
   [Sohn, Min-Sung] Cyber Univ Korea, Dept Hlth & Med Sci, 161 Jeongneung ro, Seoul 02708, South Korea.
   [Choi, Jae-Wook] Korea Univ, Coll Med, Dept Prevent Med, 73 Goryeodae ro, Seoul 02841, South Korea.
C3 Korea University; Korea University; Korea University Medicine (KU
   Medicine); Korea University; Korea University Medicine (KU Medicine)
RP Kim, YH (corresponding author), Korea Univ, Coll Med, Dept Family Med, Anam Hosp, 73 Goryeodae ro, Seoul 02841, South Sudan.; Choi, JW (corresponding author), Korea Univ, Coll Med, Dept Prevent Med, 73 Goryeodae ro, Seoul 02841, South Korea.
EM wj_9103@korea.ac.kr; lee3676@korea.ac.kr; ktg0704@hanmail.net;
   honggilyue@naver.com; hbdfm@korea.ac.kr; minsinge@cuk.edu;
   shine@korea.ac.kr; 9754031@korea.ac.kr
RI Kim, Jinkwon/AAR-6729-2021; Sohn, Minsung/AAB-9976-2020
OI BYEON, WOOJIN/0000-0003-4120-0220; han, byoungduck/0000-0003-2830-1174;
   Sohn, Minsung/0000-0001-7748-5622; Kim, Yang-Hyun/0000-0003-3548-8758
FU Taean County Office in South Korea [Q2117951]
FX This research was funded by the Taean County Office in South Korea
   (Q2117951). The study design, data analysis, and writing/approval of the
   manuscript were not influenced by the Taean County Office.
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NR 37
TC 0
Z9 0
U1 0
U2 3
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1010-660X
EI 1648-9144
J9 MEDICINA-LITHUANIA
JI Med. Lith.
PD JUL
PY 2023
VL 59
IS 7
AR 1263
DI 10.3390/medicina59071263
PG 13
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA N5RZ0
UT WOS:001037594900001
PM 37512073
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Rodrigues, MED
   Bekhbat, M
   Houser, MC
   Chang, JJ
   Walker, DI
   Jones, DP
   do Nascimento, CMPO
   Barnum, CJ
   Tansey, MG
AF de Sousa Rodrigues, Maria Elizabeth
   Bekhbat, Mandakh
   Houser, Madelyn C.
   Chang, Jianjun
   Walker, Douglas I.
   Jones, Dean P.
   Oller do Nascimento, Claudia M. P.
   Barnum, Christopher J.
   Tansey, Malu G.
TI Chronic psychological stress and high-fat high-fructose diet disrupt
   metabolic and inflammatory gene networks in the brain, liver, and gut
   and promote behavioral deficits in mice
SO BRAIN BEHAVIOR AND IMMUNITY
LA English
DT Article
DE Predatory stress; Depression; Metabolic syndrome; Insulin; Cholesterol;
   Lipocalin-2; Metabolomics; Biliverdin
ID GELATINASE-ASSOCIATED LIPOCALIN; INDUCED INSULIN-RESISTANCE; BILIVERDIN
   REDUCTASE-A; LIPID-METABOLISM; INTESTINAL PERMEABILITY;
   ALZHEIMERS-DISEASE; INDUCED OBESITY; ADIPOSE-TISSUE; RISK-FACTORS;
   LARGE-SCALE
AB The mechanisms underlying the association between chronic psychological stress, development of metabolic syndrome (MetS), and behavioral impairment in obesity are poorly understood. The aim of the present study was to assess the effects of mild chronic psychological stress on metabolic, inflammatory, and behavioral profiles in a mouse model of diet-induced obesity. We hypothesized that (1) high-fat high-fructose diet (HFHF) and psychological stress would synergize to mediate the impact of inflammation on the central nervous system in the presence of behavioral dysfunction, and that (2) HFHF and stress interactions would impact insulin and lipid metabolism. C57BI/6 male mice underwent a combination of HFHF and two weeks of chronic psychological stress. MetS-related conditions were assessed using untargeted plasma metabolomics, and structural and immune changes in the gut and liver were evaluated. Inflammation was measured in plasma, liver, gut, and brain.
   Our results show a complex interplay of diet and stress on gut alterations, energetic homeostasis, lipid metabolism, and plasma insulin levels. Psychological stress and HFHF diet promoted changes in intestinal tight junctions proteins and increases in insulin resistance and plasma cholesterol, and impacted the RNA expression of inflammatory factors in the hippocampus. Stress promoted an adaptive anti-inflammatory profile in the hippocampus that was abolished by diet treatment. HFHF increased hippocampal and hepatic Lcn2 mRNA expression as well as LCN2 plasma levels. Behavioral changes were associated with HFHF and stress. Collectively, these results suggest that diet and stress as pervasive factors exacerbate MetS-related conditions through an inflammatory mechanism that ultimately can impact behavior. This rodent model may prove useful for identification of possible biomarkers and therapeutic targets to treat metabolic syndrome and mood disorders. (C) 2016 Elsevier Inc. All rights reserved.
C1 [de Sousa Rodrigues, Maria Elizabeth; Bekhbat, Mandakh; Houser, Madelyn C.; Chang, Jianjun; Barnum, Christopher J.; Tansey, Malu G.] Emory Univ, Sch Med, Dept Physiol, 605L Whitehead Biomed Res Bldg,615 Michael St, Atlanta, GA 30322 USA.
   [Walker, Douglas I.; Jones, Dean P.] Emory Univ, Sch Med, Div Pulm Allergy & Crit Care Med, Atlanta, GA USA.
   [de Sousa Rodrigues, Maria Elizabeth; Oller do Nascimento, Claudia M. P.] Univ Fed Sao Paulo, Dept Physiol Nutr, Sao Paulo, SP, Brazil.
   [Walker, Douglas I.; Jones, Dean P.] Emory Univ, Sch Med, Div Pulm Allergy & Crit Care Med, Clin Biomarkers Lab, Whitehead Biomed Res Bldg,Room 225, Atlanta, GA USA.
   [Oller do Nascimento, Claudia M. P.] Univ Fed Sao Paulo, Dept Fisiol, Disciplina Fisiol Nutr, Edificio Ciencias Biomed,Rua Botucatu 862, BR-04023060 Sao Paulo, SP, Brazil.
C3 Emory University; Emory University; Universidade Federal de Sao Paulo
   (UNIFESP); Emory University; Universidade Federal de Sao Paulo (UNIFESP)
RP Tansey, MG (corresponding author), Emory Univ, Sch Med, 605L Whitehead Biomed Res Bldg,615 Michael St, Atlanta, GA 30322 USA.
EM mdesou2@emory.edu; mandakh.bekhbat@emory.edu; mcrawf4@emory.edu;
   jchan47@emory.edu; Douglas.Walker@emory.edu; dpjones@emory.edu;
   claudia.oller@unifesp.br; cjbarnum@me.com; malu.tansey@emory.edu
RI Rodrigues, Maria/MTE-5659-2025; Bekhbat, Mandakh/GQA-7632-2022; Chang,
   Jianjun/LRU-6269-2024; Barnum, Christopher/AAB-1127-2019; do Nascimento,
   Claudia/T-4151-2019; Houser, Madelyn/AAK-8387-2021
OI Bekhbat, Mandakh/0000-0003-1093-5160; Houser,
   Madelyn/0000-0002-4049-9876; Barnum, Christopher/0000-0003-2308-4166
FU Emory Multiplexed Immunoassay Core (EMIC); Emory University School of
   Medicine; National Center for Advancing Translational Sciences of the
   National Institutes of Health [UL1TR000454]; NIH/NIMHS
   [1R43MH105048-01A1]
FX The authors would like to thank Dr. Frank Anania and Raymond J. Tesi for
   useful discussions and Jaegwon Chung for technical assistance with QPCR.
   The present study was supported in part by the Emory Multiplexed
   Immunoassay Core (EMIC), which is subsidized by the Emory University
   School of Medicine and is one of the Emory Integrated Core Facilities.
   Additional support was provided by the National Center for Advancing
   Translational Sciences of the National Institutes of Health under Award
   Number UL1TR000454. The content is solely the responsibility of the
   authors and does not necessarily reflect the official views of the
   National Institutes of Health. Other funding support for this study was
   obtained from NIH/NIMHS 1R43MH105048-01A1 (MGT and RJT).
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NR 128
TC 72
Z9 80
U1 0
U2 53
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0889-1591
EI 1090-2139
J9 BRAIN BEHAV IMMUN
JI Brain Behav. Immun.
PD JAN
PY 2017
VL 59
BP 158
EP 172
DI 10.1016/j.bbi.2016.08.021
PG 15
WC Immunology; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Neurosciences & Neurology; Psychiatry
GA EF8YU
UT WOS:000390618700016
PM 27592562
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Lee, YB
   Yu, JH
   Choi, HH
   Jeon, BS
   Kim, HK
   Kim, SW
   Kim, SS
   Park, YG
   Chae, HS
AF Lee, Young Bok
   Yu, Jihan
   Choi, Hyun Ho
   Jeon, Bu Seok
   Kim, Hyung-Keun
   Kim, Sang-Woo
   Kim, Sung Soo
   Park, Yong Gyu
   Chae, Hiun Suk
TI The association between peptic ulcer diseases and mental health problems
   A population-based study: a STROBE compliant article
SO MEDICINE
LA English
DT Article
DE depressed mood; mental health; peptic ulcer disease; severe stress;
   suicidal ideation
ID HELICOBACTER-PYLORI; ANXIETY DISORDERS; EMOTIONAL-STRESS; MEDICAL
   ILLNESS; DUODENAL-ULCER; GASTRIC-ULCER; PREVALENCE; RISK; DEPRESSION;
   DYSPEPSIA
AB This study aimed to investigate the association between the prevalence of peptic ulcer disease (PUD) and mental health problems, such as severe stress, depressive mood, and suicidal ideation.
   The population-based cross-sectional study was comprised of 14,266 subjects participating in the fourth annual Korea National Health and Nutrition Examination survey from 2007 to 2009. The participants were divided into 2 groups according to the self-reported questionnaires: the PUD group and the non-PUD group. The association between PUD and mental health problems, such as severe stress, depressed mood, suicidal ideation, and psychological counseling history, were evaluated by using multivariate analysis and logistic regression.
   Among the 14,266 participants over 19-years old, 813 participants (5.6%) had PUD. Compared to the non-PUD group (n = 13,453), the PUD group had a significantly higher percentage of males, current smokers, and heavy drinkers, lower education status, lower income, and greater presence of diabetes mellitus, hypertension, metabolic syndrome and mental health problems, including severe stress, depressed mood, suicidal ideation, and psychological counseling history. After adjustment for lifestyle and medical and environmental factors, mental health problems were found to be associated with a significantly higher risk for PUD.
   Psychological problems, such as severe stress, depressed mood, suicidal ideation, and psychological counseling, were associated with PUD prevalence.
C1 [Lee, Young Bok] Catholic Univ Korea, Dept Dermatol, Seoul, South Korea.
   [Yu, Jihan; Chae, Hiun Suk] HeeMyoung Gen Hosp, Dept Internal Med, Seoul, South Korea.
   [Choi, Hyun Ho; Jeon, Bu Seok; Kim, Hyung-Keun; Kim, Sang-Woo; Kim, Sung Soo] Catholic Univ Korea, Dept Internal Med, Seoul, South Korea.
   [Park, Yong Gyu] Catholic Univ Korea, Dept Med Stat, Seoul, South Korea.
C3 Catholic University of Korea; Catholic University of Korea; Catholic
   University of Korea
RP Chae, HS (corresponding author), Catholic Univ Korea, Dept Internal Med, Uijeongbu St Marys Hosp, Coll Med, Uijeongbu Si, Gyeonggi Do, South Korea.
EM chs@catholic.ac.kr
RI Kim, Seok-Hwan/G-9981-2015; Lee, Young Bok/AAZ-6426-2021
OI Kim, Seok-Hwan/0000-0003-0209-0444; Lee, Young Bok/0000-0002-8642-2479
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NR 29
TC 34
Z9 35
U1 0
U2 36
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD AUG
PY 2017
VL 96
IS 34
AR e7828
DI 10.1097/MD.0000000000007828
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA FE9DQ
UT WOS:000408504800026
PM 28834889
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Tsai, AC
   Tsai, HJ
AF Tsai, A. C.
   Tsai, H. J.
TI Functional impairment but not metabolic syndrome is associated with
   depression in older Taiwanese: Results from the social environment and
   biomarkers of Aging study
SO JOURNAL OF NUTRITION HEALTH & AGING
LA English
DT Article
DE Depression; functional impairment; metabolic syndrome
ID NUTRITION EXAMINATION SURVEY; 3RD NATIONAL-HEALTH; PRIMARY-CARE;
   YOUNG-ADULTS; RISK-FACTORS; SYMPTOMS; DISABILITY; ANXIETY;
   SYMPTOMATOLOGY; PREVALENCE
AB This study examined the association of metabolic syndrome, metabolic disorders and functional impairment with depression in older (a parts per thousand yen54 years) adults.
   A cross-sectional study. Setting: Data of this study were from the Social Environment and Biomarkers of Aging Study (SEBAS) in Taiwan (2000).
   A national representative sample of persons 54 years of age or older in Taiwan (N = 1023).
   Results showed that the presence of any number of metabolic disorders without functional impairment was not associated with depression. However, the presence of functional impairment regardless of the number of metabolic disorder was associated with a significantly higher risk of depression after adjusting for confounding factors (OR = 5.13, 95% CI = 2.13-12.36) (p < 0.05). The presence of a basic Activities of Daily Living (ADL) dependency was significantly associated with a 1.45 times higher likelihood of depression (OR = 1.45, 95% CI = 1.17-1.79) (p < 0.05).
   Results suggest that functional impairment, but not metabolic syndrome or metabolic disorders, is associated with depression in older adults. Metabolic syndrome/disorders do not necessarily affect patient's psychological health unless it is accompanied with functional impairment.
C1 [Tsai, H. J.] I Shou Univ, Dept Hlth Management, Kaohsiung 82445, Taiwan.
   [Tsai, A. C.] Asia Univ, Dept Healthcare Adm, Taichung, Taiwan.
   [Tsai, A. C.] China Med Univ, Sch Publ Hlth, Dept Hlth Serv Management, Taichung, Taiwan.
C3 I Shou University; Asia University Taiwan; China Medical University
   Taiwan
RP Tsai, HJ (corresponding author), I Shou Univ, Dept Hlth Management, Kaohsiung 82445, Taiwan.
EM hsinjen@gmail.com
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NR 28
TC 4
Z9 4
U1 0
U2 6
PU SPRINGER FRANCE
PI PARIS
PA 22 RUE DE PALESTRO, PARIS, 75002, FRANCE
SN 1279-7707
J9 J NUTR HEALTH AGING
JI J. Nutr. Health Aging
PD MAY
PY 2012
VL 16
IS 5
BP 492
EP 496
DI 10.1007/s12603-012-0025-0
PG 5
WC Geriatrics & Gerontology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Nutrition & Dietetics
GA 958LP
UT WOS:000305239200015
PM 22555797
OA hybrid
DA 2025-06-11
ER

PT J
AU Misra, A
   Khurana, L
AF Misra, Anoop
   Khurana, Lokesh
TI The Metabolic Syndrome in South Asians: Epidemiology, Determinants, and
   Prevention
SO METABOLIC SYNDROME AND RELATED DISORDERS
LA English
DT Review
ID C-REACTIVE PROTEIN; CORONARY-HEART-DISEASE; BODY-MASS INDEX;
   INSULIN-RESISTANCE-SYNDROME; OBSTRUCTIVE SLEEP-APNEA; CARDIOVASCULAR
   RISK-FACTORS; MAGNETIC-RESONANCE-SPECTROSCOPY; FATTY LIVER-DISEASE;
   CHENNAI URBAN-POPULATION; TYPE-2 DIABETES-MELLITUS
AB Background: The prevalence of obesity and the metabolic syndrome is rapidly increasing in India and other south Asian countries, leading to increased morbidity and mortality due to type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD).
   Methods: The literature search has been carried out using the key words "insulin resistance, the metabolic syndrome, cardiovascular risk, diabetes, obesity, Asian Indians, and South Asians" in the medical search engine Pubmed (National Library of Medicine, Bethesda, MD) from 1966 to September 2009.
   Results: A high prevalence of the metabolic syndrome and associated cardiovascular risk factors has been observed not only in urban South Asian/Asian Indian adults and children but also in economically disadvantaged people residing in urban slums and rural areas. The main drivers are rapid nutrition, lifestyle, and socioeconomic transitions, consequent to increasing affluence, urbanization, mechanization, and rural-to-urban migration. Less investigated determinants of the metabolic syndrome include psychological stress in urban setting, genetic predisposition, adverse perinatal environment, and childhood "catch up" obesity. Data show atherogenic dyslipidemia, glucose intolerance, thrombotic tendency, subclinical inflammation, and endothelial dysfunction are higher in South Asians than Caucasians. Many of these manifestations are more severe and are seen at an early age (childhood) in South Asians than Caucasians. Metabolic syndrome and cardiovascular risk in South Asians is also heightened by their higher body fat, truncal subcutaneous fat, intra-abdominal fat, and ectopic fat deposition (liver fat, etc.). Further, cardiovascular risk cluster manifests at a lower level of adiposity and abdominal obesity. The cutoffs of body mass index and waist circumference for defining obesity and abdominal obesity, respectively, have been lowered and the definition of the metabolic syndrome has been revised for Asian Indians in a recent consensus statement, so that physicians could intervene early with lifestyle management. Data from a major intervention program conducted by us on urban adolescent schoolchildren in north India for prevention of obesity (the MARG project) has shown encouraging results, making it a model for any future intervention program in South Asians.
   Conclusions: Cardiometabolic risk is high in South Asians, starting at an early age. Increasing awareness of cluster of risk factors and how to prevent them should be emphasized in population-wide prevention strategies in South Asian countries, primarily focusing on children.
C1 [Misra, Anoop] Fortis Hosp, Dept Diabet & Metab Dis, Delhi, India.
   [Misra, Anoop; Khurana, Lokesh] SDA, Ctr Diabet Obes & Cholesterol Disorders, Diabet Fdn India, New Delhi, India.
RP Misra, A (corresponding author), Fortis Flt Lt Rajan Dhall Hosp, Dept Diabet & Metab Dis, New Delhi 110070, India.
EM anoopmisra@metabolicresearchindia.com
FU Science and Society Division, Department of Science and Technology,
   Ministry of Science and Technology, Government of India
FX We give our sincere thanks to Mrs. Vinita Sharma (Ministry of Science
   and Technology, Government of India) for supporting our several research
   projects. We appreciate help from the Ministry of Health, Government of
   India, the Regional Office of World Health Organization, New Delhi, and
   the Diabetes Foundation (India). This study was partially supported by a
   financial grant from Science and Society Division, Department of Science
   and Technology, Ministry of Science and Technology, Government of India.
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NR 192
TC 236
Z9 263
U1 0
U2 31
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-4196
EI 1557-8518
J9 METAB SYNDR RELAT D
JI Metab. Syndr. Relat. Disord.
PD DEC
PY 2009
VL 7
IS 6
BP 497
EP 514
DI 10.1089/met.2009.0024
PG 18
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 534IE
UT WOS:000272889000001
PM 19900153
DA 2025-06-11
ER

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SO NUTRIENTS
LA English
DT Review
DE depression; anxiety; major depressive disorder; generalized anxiety
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ID GENERALIZED ANXIETY DISORDER; MAJOR DEPRESSIVE DISORDER; METABOLIC
   SYNDROME; RISK-FACTORS; ANTIOXIDANT ACTIVITIES; BIOACTIVE COMPOUNDS;
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AB Depression and anxiety are major public health issues; however, there is an unmet need for novel, effective, and accessible treatments, particularly in rural communities. Blueberries are an unexplored nutraceutical for these conditions due to their excellent nutritional profile, with particularly high levels of polyphenols and anthocyanins and benefits on mood, cognition, and health. Here, we present a narrative review of the literature concerning the etiology and treatments of major depressive disorder (MDD) and generalized anxiety disorder (GAD). In both animal and human studies, blueberry supplementation can ameliorate behavioral symptoms of both anxiety and depression. The mechanistic underpinnings of these behavioral improvements are not fully defined, but likely involve biochemical alterations in the gut-brain axis, including to inflammatory cytokines, reactive oxygen species, and growth factors. We also review the limitations of traditional therapies in rural settings. Finally, we assess the potential benefit of nutraceutical interventions, particularly blueberries, as novel therapeutics for these distinct, yet related mental health issues.
C1 [Venable, Katy E.; Lee, Charles C.; Francis, Joseph] Louisiana State Univ, Sch Vet Med, Dept Comparat Biomed Sci, Baton Rouge, LA 70803 USA.
C3 Louisiana State University School of Veterinary Medicine; Louisiana
   State University System; Louisiana State University
RP Venable, KE (corresponding author), Louisiana State Univ, Sch Vet Med, Dept Comparat Biomed Sci, Baton Rouge, LA 70803 USA.
EM kvenab3@lsu.edu; cclee@lsu.edu; jfrancis@lsu.edu
RI Lee, Charles/AGY-0285-2022
OI Lee, Charles/0000-0001-6938-1604
FU United States Highbush Blueberry Council; National Institutes of Health
   [R01 HL 147133, R01 DC 019348, R03 NS 122892]
FX Funding was provided by the United States Highbush Blueberry Council (to
   K.E.V. and J.F.) and the National Institutes of Health grants R01 HL
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NR 190
TC 0
Z9 0
U1 2
U2 2
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD OCT
PY 2024
VL 16
IS 20
AR 3539
DI 10.3390/nu16203539
PG 18
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA K1P7D
UT WOS:001341676500001
PM 39458533
OA gold
DA 2025-06-11
ER

PT J
AU Carney, R
   Firth, J
   Pedley, R
   Law, H
   Parker, S
   Lovell, K
AF Carney, Rebekah
   Firth, Joseph
   Pedley, Rebecca
   Law, Heather
   Parker, Sophie
   Lovell, Karina
TI The clinical and behavioral cardiometabolic risk of children and young
   people on mental health inpatient units: A systematic review and
   meta-analysis
SO GENERAL HOSPITAL PSYCHIATRY
LA English
DT Review
DE Metabolic health; Inpatient psychiatry; Youth mental health; Child and
   adolescent psychiatry; Physical health risk
ID BODY-MASS INDEX; ULTRA-HIGH RISK; METABOLIC SYNDROME; PHYSICAL HEALTH;
   WEIGHT-GAIN; ADOLESCENTS; PREVALENCE; SCHIZOPHRENIA; PSYCHOSIS;
   AGGRESSION
AB Objective: Serious mental illness is associated with physical health comorbidities, however most research has focused on adults. We aimed to synthesise existing literature on clinical and behavioral cardiometabolic risk factors of young people on mental health inpatient units.
   Methods: A systematic review and meta-analysis was conducted, using electronic searches of PsycINFO, EMBASE, AMED, Cochrane Central Register of Controlled Trials, and Ovid MEDLINE. Eligible studies included child/adolescent mental health inpatient units for <25 years, reporting clinical/behavioral cardiometabolic risk factors. Studies containing adult samples, case-studies, or eating disorder populations were excluded. The main clinical outcome was weight, and main behavioral outcome was tobacco use.
   Results: Thirty-nine studies were identified (n = 809,185). Pooled prevalence rates of young people who were overweight (BMI > 25) was 32.4% (95% CI 26.1%-39.5%; n = 2789), and who were obese (BMI > 30) was 15.5% (95% CI 4.5%-41.6%; n = 2612). Pooled prevalence rates for tobacco use was 51.5% (95% CI 32.2-70.2; N = 804,018). Early signs of metabolic risk were observed; elevated blood cholesterol, presence of physical health conditions, and behavioral risk factors (e.g. physical inactivity).
   Conclusions: This review highlights the vulnerability of young people admitted to inpatient units and emphasises the opportunity to efficiently monitor, treat and intervene to target physical and mental health.
C1 [Carney, Rebekah; Law, Heather; Parker, Sophie] Greater Manchester Mental Hlth NHS Fdn Trust, Youth Mental Hlth Res Unit, Manchester, Lancs, England.
   [Carney, Rebekah; Firth, Joseph] Univ Manchester, Div Psychol & Mental Hlth, Manchester, Lancs, England.
   [Firth, Joseph] Western Sydney Univ, NICM Hlth Res Inst, Westmead, NSW, Australia.
   [Pedley, Rebecca; Lovell, Karina] Univ Manchester, Div Nursing Midwifery & Social Work, Manchester, Lancs, England.
C3 University of Manchester; Western Sydney University; University of
   Manchester
RP Carney, R (corresponding author), Greater Manchester Mental Hlth NHS Fdn Trust, Youth Mental Hlth Res Unit, Rico House,Bury New Rd, Prestwich M13 3BL, England.
EM Rebekah.carney@gmmh.nhs.uk
RI Carney, Rebekah/AAO-5205-2021; Firth, Joseph/JOZ-1679-2023; Pedley,
   Rebecca/O-4327-2014; Lovell, Karina/E-6410-2012
OI Carney, Rebekah/0000-0002-2859-6825; Pedley,
   Rebecca/0000-0002-2384-2169; Lovell, Karina/0000-0001-8821-895X; Parker,
   Sophie/0000-0001-5596-7524
FU National Institute for Health Research Applied Research Collaboration
   Greater Manchester; UK Research and Innovation Future Leaders Fellowship
   [MR/T021780/1]; FLF [MR/T021780/1] Funding Source: UKRI
FX This is independent research supported by the National Institute for
   Health Research Applied Research Collaboration Greater Manchester. The
   views expressed in this publication are those of the authors and not
   necessarily those of the National Institute for Health Research or the
   Department of Health and Social Care. JF is supported by a UK Research
   and Innovation Future Leaders Fellowship (MR/T021780/1). We also
   acknowledge Dr. Lydia Pearson for providing a critical peer review prior
   to this submission.
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NR 75
TC 15
Z9 15
U1 0
U2 6
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0163-8343
EI 1873-7714
J9 GEN HOSP PSYCHIAT
JI Gen. Hosp. Psych.
PD MAY-JUN
PY 2021
VL 70
BP 80
EP 97
DI 10.1016/j.genhosppsych.2021.03.007
EA MAR 2021
PG 18
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA YY6BT
UT WOS:000754873400011
PM 33773375
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Martinez, SS
   Gutierrez, M
   Delgado-Enciso, I
   Maisonet, J
   Pierre, AJ
   Campa, A
   Kallus, L
   Martinez, JD
AF Martinez, Sabrina Sales
   Gutierrez, Margaret
   Delgado-Enciso, Ivan
   Maisonet, Jezabel
   Pierre, Aydevis Jean
   Campa, Adriana
   Kallus, Laura
   Martinez, Janet Diaz
TI Economic and Cardiometabolic Risk Factors Are Predictors of Lower
   Thyroid Stimulating Hormone (TSH) Levels in Hispanic/Latinx Adults with
   Euthyroidism-A Community-Based Study
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Article
DE thyroid-stimulating hormone; income; food insecurity; Hispanic;
   cardiometabolic risk factors
ID CORONARY-HEART-DISEASE; FOOD INSECURITY; DISORDERS; DEPRESSION; HEALTH;
   HYPERTHYROIDISM; ASSOCIATION; PREVALENCE; RANGE; RACE
AB Thyroid hormone abnormalities are among the most common endocrine disorders comorbidly suffered alongside metabolic syndrome and type 2 diabetes mellitus (T2DM), and within the euthyroid range they may also impact other outcomes, such as mood disorders. This study aimed to observationally examine the relationship between TSH and social determinants of health and clinical measures in a euthyroid Hispanic/Latinx patient sample with a diagnosis of anxiety and/or depression disorders from a community health clinic. A needs assessment was completed using a random sample of 100 de-identified medical records of individuals who received free medical care, including mental health, at a community-based clinic. Those with low normal TSH (<2 mIU/L) compared with high normal TSH (>= 2 mIU/L) had a greater odds of food insecurity (p = 0.016) and being at 100% of the federal poverty level (p = 0.015). The low normal TSH group had significantly higher fasting glucose (p = 0.046), hemoglobin A1c (p = 0.018), and total cholesterol (p = 0.034) compared with the high normal TSH group. In those with T2DM, individuals with low normal TSH had six-times greater odds of having high fasting glucose (p = 0.022) and high hemoglobin A1c (p = 0.029). These relationships warrant further study, to inform future public health policies and follow-up care for underserved and vulnerable communities.
C1 [Martinez, Sabrina Sales; Gutierrez, Margaret; Delgado-Enciso, Ivan; Campa, Adriana; Martinez, Janet Diaz] Florida Int Univ, Robert Stempel Coll Publ Hlth & Social Work, Miami, FL 33199 USA.
   [Delgado-Enciso, Ivan] Univ Colima, Fac Med, Colima State Hlth Serv, Colima 28040, Mexico.
   [Delgado-Enciso, Ivan] Univ Colima, Cancerol State Inst, Colima State Hlth Serv, Colima 28040, Mexico.
   [Maisonet, Jezabel; Pierre, Aydevis Jean; Kallus, Laura] Caridad Ctr, Boynton Beach, FL 33472 USA.
   [Martinez, Janet Diaz] Florida Int Univ, Res Ctr Minor Inst FIU RCMI, Miami, FL 33199 USA.
C3 State University System of Florida; Florida International University;
   Universidad de Colima; Universidad de Colima; State University System of
   Florida; Florida International University
RP Martinez, JD (corresponding author), Florida Int Univ, Robert Stempel Coll Publ Hlth & Social Work, Miami, FL 33199 USA.; Martinez, JD (corresponding author), Florida Int Univ, Res Ctr Minor Inst FIU RCMI, Miami, FL 33199 USA.
EM saless@fiu.edu; mguti140@fiu.edu; ivan_delgado_enciso@ucol.mx;
   jmaisonet@caridad.org; ajeanpierre@caridad.org; campaa@fiu.edu;
   lkallus@caridad.org; jdimarti@fiu.edu
RI Sales Martinez, Sabrina/ABB-9294-2021; Delgado-Enciso, Ivan/B-1743-2018
OI Delgado-Enciso, Ivan/0000-0001-9848-862X; Jean-Pierre,
   Aydeivis/0009-0001-2438-9458; Sales Martinez,
   Sabrina/0000-0002-0158-8104; Diaz-Martinez, Janet/0000-0003-3295-4768;
   Campa, Adriana/0000-0001-8448-6033
FU Florida International University (FIU) Research Center for Minority
   Institutions (RCMI) Community Research Enhancement Grant [5U54MD012393]
FX The research was funded by the Florida International University (FIU)
   Research Center for Minority Institutions (RCMI) Community Research
   Enhancement Grant (Grant Number: 5U54MD012393). The content is solely
   the responsibility of the authors and does not necessarily represent the
   official views of NIHMD/NIH.
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NR 62
TC 1
Z9 1
U1 0
U2 4
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD JUL
PY 2022
VL 19
IS 13
AR 8142
DI 10.3390/ijerph19138142
PG 11
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA 2Y2DD
UT WOS:000825699700001
PM 35805800
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Lever-van Milligen, BA
   Verhoeven, JE
   Schmaal, L
   van Velzen, LS
   Révész, D
   Black, CN
   Han, LKM
   Horsfall, M
   Batelaan, NM
   van Balkom, AJLM
   van Schaik, DJF
   van Oppen, P
   Penninx, BWJH
AF Lever-van Milligen, Bianca A.
   Verhoeven, Josine E.
   Schmaal, Lianne
   van Velzen, Laura S.
   Revesz, Dora
   Black, Catherine N.
   Han, Laura K. M.
   Horsfall, Melany
   Batelaan, Neeltje M.
   van Balkom, Anton J. L. M.
   van Schaik, Digna J. F.
   van Oppen, Patricia
   Penninx, Brenda W. J. H.
TI The impact of depression and anxiety treatment on biological aging and
   metabolic stress: study protocol of the Mood treatment with
   antidepressants or running (MOTAR) study
SO BMC PSYCHIATRY
LA English
DT Article
DE Depression; Anxiety; Treatment; Antidepressant; SSRI; Running therapy;
   Aging; Telomere length; Telomerase activity; Inflammation; Metabolic
   syndrome; Cortisol; fMRI
ID LEUKOCYTE TELOMERE LENGTH; C-REACTIVE PROTEIN; LIFE-STYLE CHANGES;
   OXIDATIVE STRESS; INFLAMMATORY RESPONSES; ENDOTHELIAL FUNCTION;
   HIPPOCAMPAL VOLUME; CORTICAL THICKNESS; PHYSICAL-ACTIVITY; BRAIN VOLUME
AB Background: Depressive and anxiety disorders have shown to be associated to premature or advanced biological aging and consequently to adversely impact somatic health. Treatments with antidepressant medication or running therapy are both found to be effective for many but not all patients with mood and anxiety disorders. These interventions may, however, work through different pathophysiological mechanisms and could differ in their impact on biological aging and somatic health. This study protocol describes the design of an unique intervention study that examines whether both treatments are similarly effective in reducing or reversing biological aging (primary outcome), psychiatric status, metabolic stress and neurobiological indicators (secondary outcomes).
   Methods: The MOod Treatment with Antidepressants or Running (MOTAR) study will recruit a total of 160 patients with a current major depressive and/or anxiety disorder in a mental health care setting. Patients will receive a 16-week treatment with either antidepressant medication or running therapy (3 times/week). Patients will undergo the treatment of their preference and a subsample will be randomized (1:1) to overcome preference bias. An additional no-disease-no-treatment group of 60 healthy controls without lifetime psychopathology, will be included as comparison group for primary and secondary outcomes at baseline. Assessments are done at week 0 for patients and controls, and at week 16 and week 52 for patients only, including written questionnaires, a psychiatric and medical examination, blood, urine and saliva collection and a cycle ergometer test, to gather information about biological aging (telomere length and telomerase activity), mental health (depression and anxiety disorder characteristics), general fitness, metabolic stress-related biomarkers (inflammation, metabolic syndrome, cortisol) and genetic determinants. In addition, neurobiological alterations in brain processes will be assessed using structural and functional Magnetic Resonance Imaging (MRI) in a subsample of at least 25 patients per treatment arm and in all controls.
   Discussion: This intervention study aims to provide a better understanding of the impact of antidepressant medication and running therapy on biological aging, metabolic stress and neurobiological indicators in patients with depressive and anxiety disorders in order to guide a more personalized medicine treatment.
C1 [Lever-van Milligen, Bianca A.; Verhoeven, Josine E.; Schmaal, Lianne; van Velzen, Laura S.; Revesz, Dora; Black, Catherine N.; Han, Laura K. M.; Horsfall, Melany; Batelaan, Neeltje M.; van Balkom, Anton J. L. M.; van Schaik, Digna J. F.; van Oppen, Patricia; Penninx, Brenda W. J. H.] Vrije Univ, Amsterdam Publ Hlth Res Inst, Amsterdam UMC, Psychiat, Amsterdam, Netherlands.
   [Lever-van Milligen, Bianca A.; Verhoeven, Josine E.; Schmaal, Lianne; van Velzen, Laura S.; Revesz, Dora; Black, Catherine N.; Han, Laura K. M.; Horsfall, Melany; Batelaan, Neeltje M.; van Balkom, Anton J. L. M.; van Schaik, Digna J. F.; van Oppen, Patricia; Penninx, Brenda W. J. H.] GGZ InGeest Specialized Mental Hlth Care, Amsterdam, Netherlands.
C3 University of Amsterdam; Vrije Universiteit Amsterdam
RP Lever-van Milligen, BA (corresponding author), Vrije Univ, Amsterdam Publ Hlth Res Inst, Amsterdam UMC, Psychiat, Amsterdam, Netherlands.; Lever-van Milligen, BA (corresponding author), GGZ InGeest Specialized Mental Hlth Care, Amsterdam, Netherlands.
EM b.lever@ggzingeest.nl
RI Han, Laura/AGV-3472-2022; van Harmelen, Anne-Laura/AGH-9307-2022;
   Penninx, Brenda WJH/S-7627-2017
OI van Schaik, Anneke/0000-0002-7169-9600; Batelaan,
   Neeltje/0000-0001-6444-3781; Penninx, Brenda WJH/0000-0001-7779-9672;
   Han, Laura/0000-0001-9647-3723
FU NWO VICI grant [91811602]
FX The MOTAR study was funded by NWO VICI grant number 91811602 of B.W.J.H.
   Penninx. NWO had no role in the design of the study, the collection,
   analysis and interpretation of the data, or in the preparation, review,
   or approval of the manuscript.
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NR 117
TC 30
Z9 31
U1 1
U2 25
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-244X
J9 BMC PSYCHIATRY
JI BMC Psychiatry
PD DEC 30
PY 2019
VL 19
IS 1
AR 425
DI 10.1186/s12888-019-2404-0
PG 11
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA KJ3IA
UT WOS:000511949800001
PM 31888565
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Brooks, S
   Brnayan, KW
   DeVallance, E
   Skinner, R
   Lemaster, K
   Sheets, JW
   Pitzer, CR
   Asano, S
   Bryner, RW
   Olfert, IM
   Frisbee, JC
   Chantler, PD
AF Brooks, Steven
   Brnayan, Kayla W.
   DeVallance, Evan
   Skinner, Roy
   Lemaster, Kent
   Sheets, J. Whitney
   Pitzer, Christopher R.
   Asano, Shinichi
   Bryner, Randall W.
   Olfert, I. Mark
   Frisbee, Jefferson C.
   Chantler, Paul D.
TI Psychological stress-induced cerebrovascular dysfunction: the role of
   metabolic syndrome and exercise
SO EXPERIMENTAL PHYSIOLOGY
LA English
DT Article
DE depression; exercise; metabolic syndrome; stress; vascular
ID CHRONIC MILD STRESS; FORCED TREADMILL EXERCISE; DEPRESSIVE SYMPTOMS;
   MICROVASCULAR RAREFACTION; CEREBRAL ARTERIOLES; PHYSICAL-EXERCISE;
   OXIDATIVE STRESS; SKELETAL-MUSCLE; CARDIOVASCULAR-DISEASE; ENDOTHELIAL
   FUNCTION
AB Chronic unresolvable stress leads to the development of depression and cardiovascular disease. There is a high prevalence of depression with the metabolic syndrome (MetS), but to what extent the MetS concurrent with psychological stress affects cerebrovascular function is unknown. We investigated the differential effect of MetS on cerebrovascular structure/function in rats (16-17 weeks old) following 8 weeks of unpredictable chronic mild stress (UCMS) and whether exercise training could limit any cerebrovascular dysfunction. In healthy lean Zucker rats (LZR), UCMS decreased (28%, P < 0.05) ex vivo middle cerebral artery (MCA) endothelium-dependent dilatation (EDD), but changes in MCA remodelling and stiffness were not evident, though cerebral microvessel density (MVD) decreased (30%, P < 0.05). The presence of UCMS and MetS (obese Zucker rats; OZR) decreased MCA EDD (35%, P < 0.05) and dilatation to sodium nitroprusside (20%, P < 0.05), while MCA stiffness increased and cerebral MVD decreased (31%, P < 0.05), which were linked to reduced nitric oxide and increased oxidative levels. Aerobic exercise prevented UCMS impairments in MCA function and MVD in LZR, and partly restored MCA function, stiffness and MVD in OZR. Our data suggest that the benefits of exercise with UCMS were due to a reduction in oxidative stress and increased production of nitric oxide in the cerebral vessels. In conclusion, UCMS significantly impaired MCA structure and function, but the effects of UCMS were more substantial in OZR vs. LZR. Importantly, aerobic exercise when combined with UCMS prevented the MCA dysfunction through subtle shifts in nitric oxide and oxidative stress in the cerebral microvasculature.
C1 [Brooks, Steven] West Virginia Univ, Dept Physiol & Pharmacol, Hlth Sci Ctr, Morgantown, WV USA.
   [Brnayan, Kayla W.; DeVallance, Evan; Skinner, Roy; Sheets, J. Whitney; Pitzer, Christopher R.; Bryner, Randall W.; Olfert, I. Mark; Chantler, Paul D.] West Virginia Univ, Div Exercise Physiol, Hlth Sci Ctr, Morgantown, WV USA.
   [Lemaster, Kent; Frisbee, Jefferson C.] Univ Western Ontario, Schulich Sch Med & Dent, Dept Med Biophys, London, ON, Canada.
   [Asano, Shinichi] Fairmont State Univ, Dept Hlth & Human Performance, Fairmont, WV USA.
   [Olfert, I. Mark; Chantler, Paul D.] West Virginia Univ, Ctr Translat Stroke Res, Hlth Sci Ctr, Morgantown, WV USA.
C3 West Virginia University; West Virginia University; Western University
   (University of Western Ontario); West Virginia University
RP Chantler, PD (corresponding author), West Virginia Univ, Sch Med, Div Exercise Physiol, Robert C Byrd Hlth Sci Ctr, POB 9227, Morgantown, WV 26505 USA.
EM pchantler@hsc.wvu.edu
OI Frisbee, Jefferson/0000-0003-2751-0599
FU AHA pre-doctoral fellowship [14PRE 20380386]; National Institute of
   General Medical Sciences of the National Institutes of Health
   [U54GM104942, 5P20GM109098]
FX This study was supported by the AHA pre-doctoral fellowship 14PRE
   20380386, and the National Institute of General Medical Sciences of the
   National Institutes of Health under Award Numbers U54GM104942, and
   5P20GM109098.
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NR 67
TC 22
Z9 26
U1 0
U2 8
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0958-0670
EI 1469-445X
J9 EXP PHYSIOL
JI Exp. Physiol.
PD MAY 1
PY 2018
VL 103
IS 5
BP 761
EP 776
DI 10.1113/EP086892
PG 16
WC Physiology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Physiology
GA GE8QW
UT WOS:000431497300013
PM 29436736
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Heredia, NI
   Xu, TL
   Lee, MJ
   McNeill, LH
   Reininger, BM
AF Heredia, Natalia I.
   Xu, Tianlin
   Lee, MinJae
   McNeill, Lorna H.
   Reininger, Belinda M.
TI The Neighborhood Environment and Hispanic/Latino Health
SO AMERICAN JOURNAL OF HEALTH PROMOTION
LA English
DT Article
DE community; specific settings; active living; built environment;
   opportunity; physical activity; health disparities; mental health;
   Hispanic; Latino; Mexican American; environmental health; c-reactive
   protein; inflammation; metabolic syndrome; type 2 diabetes; depression;
   anxiety; neighborhood; crime; traffic
ID INTERNATIONAL PHYSICAL-ACTIVITY; METABOLIC SYNDROME; BUILT ENVIRONMENT;
   ASSOCIATIONS; PREVALENCE; COMMUNITY; ADULTS; STATEMENT; LATINOS; OBESITY
AB Purpose: Hispanic/Latino adults on the Texas-Mexico border have high rates of chronic disease. Neighborhoods can influence health, though there is a limited research on neighborhood environment and health in Hispanics/Latinos. The purpose of this study was to assess the relation of neighborhood environment with health variables in Hispanic/Latino adults, including physical activity [PA], depression, anxiety, and lab-assessed conditions (type 2 diabetes, metabolic syndrome, and chronic inflammation). Methods: Participants were randomly-selected from a Hispanic/Latino cohort on the Texas-Mexico border. Neighborhood environment, self-reported PA, anxiety, and depression were assessed through questionnaires. Laboratory values determined Type 2 diabetes, metabolic syndrome, and C-reactive protein (CRP). We conducted multivariable linear and logistic regression analyses to assess the associations of neighborhood environment and health variables, controlling for covariates. Results: Participants (n = 495) were mostly females, without insurance. After controlling for covariates, crime (Adjusted Odds Ratio [AOR] = 1.59 (95%CI 1.06-2.38), no streetlights (AOR = 1.65, 95%CI 1.06-2.57), and traffic (AOR = 1.74, 95%CI 1.16-2.62) were all significantly associated with anxiety. Only traffic was significantly associated with depression (AOR = 1.61, 95%CI1.05-2.47). A lack of nearby shops (AOR = 0.57, 95%CI 0.38-0.84) and no one out doing PA (AOR = 0.53, 95% CI 0.34-0.83) were both significantly associated with lower odds of meeting PA guidelines. A lack of nearby shops was associated with a 26% increase in the CRP value (beta = 0.26, 95%CI 0.04-0.47). Discussion: Several neighborhood environment variables were significantly associated with mental health, PA and CRP, though estimates were small. The neighborhood environment is a meaningful contextual variable to consider for health-related interventions in Hispanic/Latino adults, though more study is needed regarding the magnitude of the estimates.
C1 [Heredia, Natalia I.] Univ Texas Hlth Sci Ctr Houston, Dept Hlth Promot & Behav Sci, Sch Publ Hlth, 7000 Fannin St,Suite 2558, Houston, TX 77030 USA.
   [Xu, Tianlin] Univ Texas Hlth Sci Ctr Houston, Dept Biostat & Data Sci, Sch Publ Hlth, Houston, TX 77030 USA.
   [Lee, MinJae] UT SouthWestern, Dallas, TX 75390 USA.
   [McNeill, Lorna H.] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA.
   [Reininger, Belinda M.] UTHlth Sch Publ Hlth, Brownsville, TX USA.
C3 University of Texas System; University of Texas Health Science Center
   Houston; University of Texas School Public Health; University of Texas
   System; University of Texas Health Science Center Houston; University of
   Texas School Public Health; University of Texas System; University of
   Texas Southwestern Medical Center Dallas; University of Texas System;
   UTMD Anderson Cancer Center
RP Heredia, NI (corresponding author), Univ Texas Hlth Sci Ctr Houston, Dept Hlth Promot & Behav Sci, Sch Publ Hlth, 7000 Fannin St,Suite 2558, Houston, TX 77030 USA.
EM natalia.i.heredia@uth.tmc.edu
RI Xu, Tianlin/H-5660-2016; Lee, MinJae/AAK-1972-2020; Heredia,
   Natalia/AAI-1287-2021
OI Xu, Tianlin/0000-0002-5699-5540; Heredia, Natalia
   I./0000-0001-8086-3700; Lee, MinJae/0000-0002-4329-506X
FU NIH's National Center for Advancing Translational Sciences
   [UL1TR000371]; Cancer Prevention & Research Institute of Texas
   [PP110163, RP170259]; NIH/National Cancer Institute through MD
   Anderson's Cancer Center [CA016672]
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: The
   research presented in this paper is that of the authors and does not
   reflect the official policy of the NIH. The intervention and analysis
   work described in the manuscript was partially supported by the Clinical
   and Translational Science Award (UL1TR000371) from the NIH's National
   Center for Advancing Translational Sciences, the Cancer Prevention &
   Research Institute of Texas (PP110163 and RP170259), and NIH/National
   Cancer Institute through MD Anderson's Cancer Center Support Grant
   (CA016672).
CR [Anonymous], 2012, DIABETES CARE, V35, pS11, DOI [10.2337/dc35-S011, 10.2337/dc12-s004]
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NR 37
TC 14
Z9 16
U1 0
U2 4
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 0890-1171
EI 2168-6602
J9 AM J HEALTH PROMOT
JI Am. J. Health Promot.
PD JAN
PY 2022
VL 36
IS 1
BP 38
EP 45
AR 08901171211022677
DI 10.1177/08901171211022677
EA JUN 2021
PG 8
WC Public, Environmental & Occupational Health
WE Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA XN9UW
UT WOS:000664706900001
PM 34128383
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Skilton, MR
   Moulin, P
   Terra, JL
   Bonnet, F
AF Skilton, Michael R.
   Moulin, Philippe
   Terra, Jean-Louis
   Bonnet, Fabrice
TI Associations between anxiety, depression, and the metabolic syndrome
SO BIOLOGICAL PSYCHIATRY
LA English
DT Article
DE anxiety; cardiovascular disease; depression; insulin resistance;
   metabolic syndrome; obesity
ID CORONARY-HEART-DISEASE; INSULIN-RESISTANCE; HOSPITAL ANXIETY;
   YOUNG-ADULTS; RISK; SYMPTOMS; WOMEN; HEALTH; STATEMENT; COHORT
AB Background: There is limited evidence as to whether the metabolic syndrome (MetS) is associated with depression or anxiety and, if so, whether this association is gender-specific. This study investigated in each gender whether the MetS is associated with anxiety or depression and whether these relationships are independent of age, obesity, smoking status, socioeconomic factors, and lifestyle.
   Methods: Metabolic syndrome (American Heart Association/National Heart, Lung, and Blood Institute criteria), depression, and anxiety (Hospital Anxiety and Depression Scale) were assessed in 1598 subjects at risk of cardiovascular disease.
   Results: In both men and women, the MetS was associated with an increased prevalence of depression but not anxiety. The number of components of the MetS increased with increasing levels of depression but not anxiety. This association between the MetS and depressive symptoms was independent of age, smoking status, socioeconomic factors, and lifestyle. The relationship was observed across body mass index categories and was independent of anxiety.
   Conclusions: The MetS is associated with depression and depressive symptoms but not anxiety irrespective of gender and overweight/obesity status in subjects at risk of cardiovascular disease. These findings suggest a potential importance of screening for depression in patients with the MetS.
C1 Univ Lyon, Human Nutr Res Ctr, Dept Med, Lyon, France.
   Diabetol Endocrinol Cardiovasc Hosp Louis Pradel, Dept Med, INSERM, U449,INRA 1235, Lyon, France.
   Univ Lyon, Dept Psychiat, Lyon, France.
C3 CHU Lyon; INRAE; Institut National de la Sante et de la Recherche
   Medicale (Inserm)
RP Bonnet, F (corresponding author), Hop Edouard Herriot, Human Nutr Res Ctr, F-69003 Lyon, France.
EM fab.so.bonnet@free.fr
RI ; Bonnet, Fabrice/G-4255-2017
OI Skilton, Michael/0000-0003-2793-2388; Bonnet,
   Fabrice/0000-0001-9255-8228
CR Adriaanse MC, 2006, DIABETOLOGIA, V49, P2874, DOI 10.1007/s00125-006-0500-4
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NR 33
TC 240
Z9 258
U1 0
U2 22
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0006-3223
EI 1873-2402
J9 BIOL PSYCHIAT
JI Biol. Psychiatry
PD DEC 1
PY 2007
VL 62
IS 11
BP 1251
EP 1257
DI 10.1016/j.biopsych.2007.01.012
PG 7
WC Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Psychiatry
GA 233VY
UT WOS:000251119600008
PM 17553465
DA 2025-06-11
ER

PT J
AU Zupkauskiene, J
   Lauceviciene, I
   Navickas, P
   Ryliskyte, L
   Puronaite, R
   Badariene, J
   Laucevicius, A
AF Zupkauskiene, Jurate
   Lauceviciene, Ieva
   Navickas, Petras
   Ryliskyte, Ligita
   Puronaite, Roma
   Badariene, Jolita
   Laucevicius, Aleksandras
TI Changes in health-related quality of life, motivation for physical
   activity, and the levels of anxiety and depression after individualized
   aerobic training in subjects with metabolic syndrome
SO HELLENIC JOURNAL OF CARDIOLOGY
LA English
DT Article
DE aerobic exercise; metabolic syndrome; psycho -emotional state; health
   -related life quality; motivation
ID CARDIOVASCULAR PREVENTION; INTRINSIC MOTIVATION; EUROPEAN ASSOCIATION;
   INSULIN-RESISTANCE; PERCEIVED STRESS; HIGH-RISK; EXERCISE; ADULTS;
   WOMEN; SYMPTOMS
AB Objective: Numerous studies associate metabolic syndrome (MetS) with poor life quality, depression, and anxiety. Aerobic exercise training has proven its value in promoting health among subjects with MetS. We aimed to evaluate the changes in health-related quality of life (HRQOL), motivation for physical activity, and the levels of anxiety and depression in subjects with MetS after individualized aerobic training. Methods: A total of 140 subjects with MetS (53.2 +/- 6.8 years, 55% female) were analyzed after the random assignment to the intervention (n = 84) or the control group (n = 56). Only the intervention group participated in the 8-week HR targeted aerobic training program, which consisted of exercises on a cycle ergometer for 30-40 min/day, 5 days/week. In all study participants HRQOL, motivation for physical activity, anxiety and depression levels were evaluated by the Medical Outcomes Study 36-Item ShortForm Health Survey, the Exercise Motivations Inventory-2, and the Hospital Anxiety and Depression scale before and after 8 weeks. Results: After 8 weeks, self-reported physical functioning significantly increased only in the intervention group (p = 0.01). The scores of mental health-summary and role limitations due to emotional problems also improved in subjects with MetS, who participated in the aerobic training program (p < 0.001, p = 0.009, respectively). The scores for social engagement motive, enjoyment and revitalization motive, and fitness motive to exercise increased (p = 0.003, p < 0.001, p = 0.023, respectively), whereas the level of depression reduced only in the intervention group (p = 0.021). Conclusions: The 8-week individualized aerobic training had a positive effect on HRQOL, motivation for physical activity, and the level of depression in subjects with MetS. (c) 2022 Hellenic Society of Cardiology. Publishing services by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
C1 [Zupkauskiene, Jurate; Navickas, Petras; Ryliskyte, Ligita; Badariene, Jolita; Laucevicius, Aleksandras] Vilnius Univ, Fac Med, Clin Cardiac & Vasc Dis, LT-08661 Vilnius, Lithuania.
   [Lauceviciene, Ieva] Vilnius Univ, Fac Med, Dept Rehabil Phys & Sports Med, LT-03101 Vilnius, Lithuania.
   [Navickas, Petras; Laucevicius, Aleksandras] State Res Inst Ctr Innovat Med, LT-08410 Vilnius, Lithuania.
   [Puronaite, Roma] Vilnius Univ, Inst Data Sci & Digital Technol, Fac Math & Informat, LT-08412 Vilnius, Lithuania.
   [Zupkauskiene, Jurate] Vilnius Univ, Fac Med, Clin Cardiac & Vasc Dis, St ariskiu st 2, LT-08661 Vilnius, Lithuania.
C3 Vilnius University; Vilnius University; State Research Institute Centre
   for Innovative Medicine; Vilnius University; Vilnius University
RP Zupkauskiene, J (corresponding author), Vilnius Univ, Fac Med, Clin Cardiac & Vasc Dis, St ariskiu st 2, LT-08661 Vilnius, Lithuania.
EM jurate.balsyte@gmail.com
RI Navickas, Petras/AAJ-9563-2021; Puronaite, Roma/AGG-4417-2022;
   Zupkauskiene, Jurate/HGB-4001-2022
OI Laucevicius, Aleksandras/0000-0002-8642-1441; Navickas,
   Petras/0000-0002-0978-0571; Zupkauskiene, Jurate/0000-0001-7031-0731
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NR 68
TC 8
Z9 9
U1 6
U2 23
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1109-9666
EI 2241-5955
J9 HELL J CARDIOL
JI Hell. J. Cardiol.
PD JUL-AUG
PY 2022
VL 66
BP 41
EP 51
DI 10.1016/j.hjc.2022.04.003
EA AUG 2022
PG 11
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 6L3QZ
UT WOS:000888102200006
PM 35439631
OA gold
DA 2025-06-11
ER

PT J
AU Cohen, BE
   Panguluri, P
   Na, B
   Whooley, MA
AF Cohen, Beth E.
   Panguluri, Praveen
   Na, Beeya
   Whooley, Mary A.
TI Psychological risk factors and the metabolic syndrome in patients with
   coronary heart disease: Findings from the Heart and Soul Study
SO PSYCHIATRY RESEARCH
LA English
DT Article
DE Depression; Anxiety; Socioeconomic factors; Health behavior
ID C-REACTIVE PROTEIN; HOSPITAL ANXIETY; MAJOR DEPRESSION; ARTERY-DISEASE;
   YOUNG-ADULTS; STRESS; HEALTH; VALIDITY; OUTCOMES; INTERLEUKIN-6
AB Psychological factors, such as depression and anxiety, are independently associated with an increased risk of both diabetes mellitus and cardiovascular disease, but the reasons for these associations are unknown. We sought to determine whether psychological factors were associated with a greater prevalence of the metabolic syndrome in patients with coronary heart disease, and the extent to which such an association may be explained by socioeconomic status, health behaviors, and biological mediators. We conducted a cross-sectional study of 1024 outpatients with stable coronary heart disease. Psychological factors, including depressive and anxiety symptoms, hostility, anger, and optimism-pessimism, were assessed using validated standardized questionnaires. The presence or absence of the metabolic syndrome was determined using the criteria outlined by the National Cholesterol Education Program, Adult Treatment Panel III. Higher levels of depression, anger expression, hostility, and pessimism were significantly associated with increased prevalence of the metabolic syndrome. These associations were explained by differences in socioeconomic status and health behaviors. Additional adjustment for potential biological mediators had little impact. Further research is needed to determine whether addressing socioeconomic and behavioral factors in people with depression or high levels of anger or hostility could reduce the burden of the metabolic syndrome. Published by Elsevier Ireland Ltd
C1 [Cohen, Beth E.] Vet Affairs Med Ctr, Gen Internal Med Sect 111A1, San Francisco, CA 94121 USA.
   [Cohen, Beth E.; Whooley, Mary A.] Univ Calif San Francisco, Dept Med, San Francisco, CA USA.
   [Panguluri, Praveen] Univ Calif San Francisco, Sch Med, San Francisco, CA USA.
C3 US Department of Veterans Affairs; Veterans Health Administration (VHA);
   University of California System; University of California San Francisco;
   University of California System; University of California San Francisco
RP Cohen, BE (corresponding author), Vet Affairs Med Ctr, Gen Internal Med Sect 111A1, 4150 Clement St, San Francisco, CA 94121 USA.
EM Beth.Cohen@ucsf.edu
RI Na, b/KPY-6354-2024; Whooley, Mary/HTM-8411-2023
FU Department of Veterans Affairs, Washington, DC; National Heart Lungand
   Blood Institute [R01 HL079235]; American Federation for Aging Research
   (Paul Beeson Scholars Program), New York, NY; Robert Wood Johnson
   Foundation (Faculty Scholars Program), Princeton, NJ; Ischemia Research
   and Education Foundation, South San Francisco, CA; Nancy Kirwan Heart
   Research Fund, San Francisco, CA; NIH/NCRR UCSF-CTSI [ULI RR024130]
FX The Heart and Soul Study was funded by the Department of Veterans
   Affairs, Washington, DC, the National Heart Lungand Blood Institute (R01
   HL079235), Bethesda, MD, the American Federation for Aging Research
   (Paul Beeson Scholars Program), New York, NY, the Robert Wood Johnson
   Foundation (Faculty Scholars Program), Princeton, NJ, the Ischemia
   Research and Education Foundation, South San Francisco, CA, and the
   Nancy Kirwan Heart Research Fund, San Francisco, CA. Dr. Cohen was
   supported by NIH/NCRR UCSF-CTSI Grant Number ULI RR024130. The article's
   contents are solely the responsibility of the authors and do not
   necessarily represent the official views of the NIH.
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NR 48
TC 78
Z9 88
U1 1
U2 17
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0165-1781
EI 1872-7123
J9 PSYCHIAT RES
JI Psychiatry Res.
PD JAN
PY 2010
VL 175
IS 1-2
BP 133
EP 137
DI 10.1016/j.psychres.2009.02.004
PG 5
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 553NT
UT WOS:000274374800024
PM 19969373
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Barber, TA
   Ringwald, WR
   Wright, AGC
   Manuck, SB
AF Barber, Taylor A.
   Ringwald, Whitney R.
   Wright, Aidan G. C.
   Manuck, Stephen B.
TI Borderline Personality Disorder Traits Associate With Midlife
   Cardiometabolic Risk
SO PERSONALITY DISORDERS-THEORY RESEARCH AND TREATMENT
LA English
DT Article
DE borderline personality disorder; personality pathology; cardiometabolic
   risk; cardiovascular disease; depression
ID CARDIOVASCULAR-DISEASE RISK; CORONARY-HEART-DISEASE; HIGHER-ORDER
   FACTORS; METABOLIC SYNDROME; DEPRESSION; METAANALYSIS; COMORBIDITY;
   PREVALENCE; PREVENTION; INVENTORY
AB There is growing interest in relationships between borderline personality disorder (BPD) pathology and physical health outcomes. Diagnostic BPD and BPD-related traits, for instance, have been shown to associate with self-reported cardiovascular disease and various cardiometabolic risk factors. However, potential confounding of these associations by comorbid depression, which itself contributes to risk for heart disease, remains unresolved, and previous research is limited by nearly uniform reliance on self-reported health status. In the present study, we examine the association of BPD traits and contemporaneously assessed depressive mood with instrumented measures of cardiometabolic risk in a midlife community sample (N = 1,295). BPD pathology was measured using dimensional, multi-informant trait measures; depressive symptomology was self-reported; and cardiometabolic risk was indexed via multiple indicators of insulin resistance, adiposity, dyslipidemia. and blood pressure. Structural equation modeling was used to estimate the effects of BPD traits and depressive symptoms on aggregated cardiometabolic risk, adjusting for their shared variance. Results showed both BPD features and depressive symptomatology related to the extent of cardiometabolic risk; when examined simultaneously, only BPD associated independently with risk indicators. In further supporting a link between BPD pathology and cardiovascular disease risk, these findings warrant future work to elucidate intervening behavioral and biological mechanism.
C1 [Barber, Taylor A.] Philadelphia Coll Osteopath Med, Dept Osteopath Med, Philadelphia, PA USA.
   [Ringwald, Whitney R.; Wright, Aidan G. C.; Manuck, Stephen B.] Univ Pittsburgh, Dept Psychol, 4305 Sennott Sq,210 South Bouquet St, Pittsburgh, PA 15260 USA.
C3 Philadelphia College of Osteopathic Medicine; Pennsylvania Commonwealth
   System of Higher Education (PCSHE); University of Pittsburgh
RP Ringwald, WR (corresponding author), Univ Pittsburgh, Dept Psychol, 4305 Sennott Sq,210 South Bouquet St, Pittsburgh, PA 15260 USA.
EM WRR12@pitt.edu
RI Wright, Aidan/W-2821-2019
OI Barber, Taylor/0000-0001-9730-3056; Wright, Aidan/0000-0002-2369-0601
FU National Institute of Health [PO1 HL040962]
FX This research was supported by a grant from the National Institute of
   Health (PO1 HL040962, Principal Investigator: Stephen B. Manuck). The
   views contained in the manuscript are those of the authors and not
   necessarily those of the funding source. Taylor A. Barber and Whitney R.
   Ringwald contributed equally to this project; they share first
   authorship.
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NR 44
TC 11
Z9 11
U1 0
U2 5
PU EDUCATIONAL PUBLISHING FOUNDATION-AMERICAN PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST, NE, WASHINGTON, DC 20002-4242 USA
SN 1949-2715
EI 1949-2723
J9 PERSONAL DISORD
JI Personal. Disord.
PD MAR
PY 2020
VL 11
IS 2
BP 151
EP 156
DI 10.1037/per0000373
PG 6
WC Psychology, Clinical
WE Social Science Citation Index (SSCI)
SC Psychology
GA KQ2RX
UT WOS:000516776900008
PM 31647268
OA Green Submitted, Green Accepted
DA 2025-06-11
ER

PT J
AU Meaney, E
   Vela, A
   Samaniego, V
   Meaney, A
   Asbún, J
   Zempoalteca, JC
   Elisa, ZN
   Emma, MN
   Guzman, M
   Hicks, J
   Ceballos, G
AF Meaney, Eduardo
   Vela, Agustin
   Samaniego, Virginia
   Meaney, Alejandra
   Asbun, Juan
   Zempoalteca, Juan-Carlos
   Elisa, Zarate N.
   Emma, Mendoza N.
   Guzman, Martin
   Hicks, Juan
   Ceballos, Guillermo
TI Metformin, arterial function, intima-media thickness and nitroxidation
   in metabolic syndrome:: The mefisto study
SO CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
LA English
DT Article
DE arterial stiffness; intima-media thickness; metabolic syndrome;
   metformin; nitroxidation
ID POLYCYSTIC-OVARY-SYNDROME; INSULIN-RESISTANCE SYNDROME; TYPE-2
   DIABETES-MELLITUS; FACTOR-KAPPA-B; ENDOTHELIAL DYSFUNCTION; OXIDATIVE
   STRESS; CARDIOVASCULAR-DISEASE; LIPID-PEROXIDATION; DOUBLE-BLIND;
   RISK-FACTOR
AB 1. Metabolic syndrome (MS) is one of the greatest public health problems in Mexico, where more than 75% of adults in urban populations are overweight or obese. Metabolic syndrome has several comorbidities, which result in a high cardiometabolic risk.
   2. Some of the vasopathogenic phenomena in MS are caused by nitroxidant stress, secondary to cardiometabolic dysfunction.
   3. The action of metformin to diminish or control MS remains a matter of debate.
   4. In the present study, 60 patients with at least three diagnostic criteria for MS were divided into two groups. Both groups received similar dietary counselling, but one group was given 850 mg metformin daily.
   5. The variables assessed were body mass index, waist circumference, systolic and diastolic blood pressures (SBP and DBP, respectively), total cholesterol (TC), high- and low-density lipoprotein-cholesterol, triglycerides (TG), fasting glucose, nitroxidant metabolites (free carbonyls, malondialdehyde, dityrosines and advanced oxidative protein products (AOPP)), nitric oxide (NO), carotid vascular stiffness, carotid intima-media thickness (IMT) and C-reactive protein (CRP).
   6. After 1 year follow up, both groups reported weight loss, as well as decreases in waist circumference, SBP and DBP.
   7. Patients on metformin exhibited reductions in TC and IMT and there were marked changes in nitroxidation: levels of carbonyls, dityrosines and AOPP were reduced, whereas those of NO were increased, indicating better endothelial function. In addition, in patients given metformin, CRP levels decreased.
   8. In conclusion, metformin has a considerable beneficial effect on nitroxidation, endothelial function and IMT in patients with MS.
C1 [Meaney, Eduardo; Vela, Agustin; Samaniego, Virginia; Meaney, Alejandra; Emma, Mendoza N.] Regional Hosp October 1st ISSSTE, Cardiovasc Unit, Mexico City 07300, DF, Mexico.
   [Asbun, Juan; Zempoalteca, Juan-Carlos; Elisa, Zarate N.; Ceballos, Guillermo] Natl Polytechn Inst, Sch Med, Postgrad Studies & Res Sect, Mexico City, DF, Mexico.
   [Guzman, Martin; Hicks, Juan] Natl Inst Resp Dis, Mexico City, DF, Mexico.
C3 Instituto Politecnico Nacional - Mexico
RP Ceballos, G (corresponding author), Regional Hosp October 1st ISSSTE, Cardiovasc Unit, Avenida Politecn Nacl 669,Colonia Magdalena Salin, Mexico City 07300, DF, Mexico.
EM gceballosr@ipn.mx
RI ASBUN, JUAN/C-3979-2016; Ceballos, Guillermo/A-7507-2013
OI Ceballos, Guillermo/0000-0003-2155-3934
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NR 79
TC 71
Z9 79
U1 0
U2 6
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0305-1870
EI 1440-1681
J9 CLIN EXP PHARMACOL P
JI Clin. Exp. Pharmacol. Physiol.
PD AUG
PY 2008
VL 35
IS 8
BP 895
EP 903
DI 10.1111/j.1440-1681.2008.04920.x
PG 9
WC Pharmacology & Pharmacy; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Physiology
GA 323VI
UT WOS:000257476100007
PM 18346173
DA 2025-06-11
ER

PT J
AU Herva, A
   Rasanen, P
   Miettunen, J
   Timonen, M
   Laksy, K
   Veijola, J
   Laitinen, J
   Ruokonen, A
   Joukamaa, M
AF Herva, A
   Rasanen, P
   Miettunen, J
   Timonen, M
   Laksy, K
   Veijola, J
   Laitinen, J
   Ruokonen, A
   Joukamaa, M
TI Co-occurrence of metabolic syndrome with depression and anxiety in young
   adults: The Northern Finland 1966 Birth Cohort Study
SO PSYCHOSOMATIC MEDICINE
LA English
DT Article
DE depression; HSCL-25; metabolic syndrome; cohort study
ID HOPKINS SYMPTOM CHECKLIST-25; 3RD NATIONAL-HEALTH; RISK-FACTOR;
   HYPERTENSION; MORBIDITY; MORTALITY; STATES; TYPE-2; HEART; CARE
AB Objective: Only a few studies have dealt with the association of metabolic syndrome with depression and anxiety. We studied whether metabolic syndrome and its components are associated with depressive and anxiety symptoms in a young adult population cohort. Methods: This study forms part of the Northern Finland 1966 Birth Cohort Study. The study sample consists of 5,698 members of the cohort who participated in the field study in 1997 to 1998. Metabolic syndrome was defined according to the five criteria of the National Cholesterol Education Program. Depressive and anxiety symptoms were defined by the Hopkins Symptom Checklist-25 questionnaire. Results: Metabolic syndrome was not associated with depression or anxiety. The correlations between the components of the metabolic syndrome and psychological distress as continuous measures were low. High waist circumference (> 102 cm in males and > 88 cm in females) associated with depression (odds ratio, 1.30; 95% confidence interval, 1.05-1.61), but this association vanished when adjusted for gender, smoking, alcohol consumption, marital status, level of education, and physical activity. Conclusion: No clear association was found between the metabolic syndrome and psychological distress.
C1 Univ Hosp Oulu, Dept Psychiat, FIN-90029 Oys, Finland.
   Oulu Univ, Dept Publ Hlth Sci & Gen Practice, SF-90220 Oulu, Finland.
   Oulu Hlth Ctr, Oulu, Finland.
   Oulu Univ, Acad Finland, SF-90220 Oulu, Finland.
   Oulu Univ, Dept Psychiat, SF-90220 Oulu, Finland.
   Oulu Reg Inst Occupat Hlth, Oulu, Finland.
   Oulu Univ, Dept Clin Chem, SF-90220 Oulu, Finland.
   Tampere Univ, Tampere Sch Publ Hlth, Dept Social Psychiat, FIN-33101 Tampere, Finland.
   Tampere Univ, Dept Psychiat, FIN-33101 Tampere, Finland.
C3 University of Oulu; Research Council of Finland; University of Oulu;
   University of Oulu; University of Oulu; Tampere University; Tampere
   University
RP Univ Hosp Oulu, Dept Psychiat, Pl 26, FIN-90029 Oys, Finland.
EM anne.herva@oulu.fi
RI Miettunen, Jouko/AAC-4334-2019
OI Miettunen, Jouko/0000-0003-0575-2669
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NR 32
TC 131
Z9 141
U1 0
U2 8
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0033-3174
EI 1534-7796
J9 PSYCHOSOM MED
JI Psychosom. Med.
PD MAR-APR
PY 2006
VL 68
IS 2
BP 213
EP 216
DI 10.1097/01.psy.0000203172.02305.ea
PG 4
WC Psychiatry; Psychology; Psychology, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry; Psychology
GA 029VB
UT WOS:000236591400006
PM 16554385
DA 2025-06-11
ER

PT J
AU Rasmusson, AM
   Schnurr, PP
   Zukowska, Z
   Scioli, E
   Forman, DE
AF Rasmusson, Ann M.
   Schnurr, Paula P.
   Zukowska, Zofia
   Scioli, Erica
   Forman, Daniel E.
TI Adaptation to extreme stress: post-traumatic stress disorder,
   neuropeptide Y and metabolic syndrome
SO EXPERIMENTAL BIOLOGY AND MEDICINE
LA English
DT Article; Proceedings Paper
CT Annual FASEB Experimental Biology Meeting
CY APR 21, 2009
CL San Diego, CA
DE metabolic syndrome; post-traumatic stress disorder; neuropeptide Y;
   obesity hypertension; neurosteroids; depression; dehydroepiandrosterone;
   testosterone; cortisol; allopregnanolone
ID ALPHA(2C)-ADRENORECEPTOR GENE POLYMORPHISM; AMBULATORY CARDIOVASCULAR
   ACTIVITY; CONGENITAL ADRENAL-HYPERPLASIA;
   CORTICOTROPIN-RELEASING-FACTOR; RECEPTOR ANTAGONIST BIBP3226;
   DEHYDROEPIANDROSTERONE-SULFATE; MAJOR DEPRESSION; BLOOD-PRESSURE;
   FOOD-INTAKE; PLASMA DEHYDROEPIANDROSTERONE
AB The prevalence rates of obesity and metabolic syndrome are on the rise in the United States. Epidemiological surveys suggest that the rates of these medical conditions are especially high among persons with psychiatric disorders, including post-traumatic stress disorder (PTSD). A variety of factors are thought to contribute to the risk for metabolic syndrome, including excessive caloric intake, decreased activity and energy expenditure, use of certain medications, stress and genetic influences. Recent research demonstrates that stress, acting through the neuropeptide Y (NPY) and glucocorticoid systems, potentiates the development of obesity and other aspects of metabolic syndrome in mice fed a high caloric, fat and sugar diet. Alterations in the NPY and glucocorticoid systems also impact behavioral adaptation to stress, as indicated by studies in animals and persons exposed to severe, life-threatening or traumatic stress. The following review examines the biology of the NPY and neuroactive steroid systems as physiological links between metabolic syndrome and PTSD, a paradigmatic neuropsychiatric stress disorder. Hopefully, understanding the function of these systems from both a translational and systems biology point of view in relation to stress will enable development of more effective methods for preventing and treating the negative physical and mental health consequences of stress.
C1 [Rasmusson, Ann M.; Scioli, Erica; Forman, Daniel E.] VA Boston Healthcare Syst, Boston, MA 02130 USA.
   [Rasmusson, Ann M.; Scioli, Erica] Natl Ctr PTSD, Womens Hlth Sci Div, Boston, MA 02130 USA.
   [Rasmusson, Ann M.; Scioli, Erica] Boston Univ, Sch Med, Boston, MA 02118 USA.
   [Schnurr, Paula P.] Natl Ctr PTSD, Execut Div, White River Jct, VT 05009 USA.
   [Schnurr, Paula P.] Dartmouth Med Sch, Hanover, NH 03755 USA.
   [Zukowska, Zofia] Georgetown Univ, Med Ctr, Dept Physiol & Biophys, Washington, DC 20057 USA.
   [Zukowska, Zofia] Georgetown Univ, Med Ctr, Stress Physiol & Res Ctr, Washington, DC 20057 USA.
   [Forman, Daniel E.] Brigham & Womens Hosp, Boston, MA 02115 USA.
   [Forman, Daniel E.] Harvard Univ, Sch Med, Boston, MA 02115 USA.
C3 Harvard University; Harvard University Medical Affiliates; US Department
   of Veterans Affairs; Veterans Health Administration (VHA); VA Boston
   Healthcare System; Harvard University; Harvard University Medical
   Affiliates; US Department of Veterans Affairs; Veterans Health
   Administration (VHA); VA Boston Healthcare System; Boston University;
   Dartmouth College; Georgetown University; Georgetown University; Harvard
   University; Harvard University Medical Affiliates; Brigham & Women's
   Hospital; Harvard University; Harvard Medical School
RP Rasmusson, AM (corresponding author), VA Boston Healthcare Syst, 116B3,150 S Huntington Ave, Boston, MA 02130 USA.
EM ann.rasmusson@gmail.com
OI Rasmusson, Ann/0000-0002-3488-9042
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NR 161
TC 94
Z9 104
U1 0
U2 29
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1535-3702
EI 1535-3699
J9 EXP BIOL MED
JI Exp. Biol. Med.
PD OCT
PY 2010
VL 235
IS 10
BP 1150
EP 1162
DI 10.1258/ebm.2010.009334
PG 13
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Research & Experimental Medicine
GA 670VN
UT WOS:000283455500003
PM 20881319
DA 2025-06-11
ER

PT J
AU Kavyani, M
   Saleh-Ghadimi, S
   Dehghan, P
   Farhangi, MA
   Khoshbaten, M
AF Kavyani, Maryam
   Saleh-Ghadimi, Sevda
   Dehghan, Parvin
   Abbasalizad Farhangi, Mahdieh
   Khoshbaten, Manouchehr
TI Co-supplementation of camelina oil and a prebiotic is more effective for
   in improving cardiometabolic risk factors and mental health in patients
   with NAFLD: a randomized clinical trial
SO FOOD & FUNCTION
LA English
DT Article
ID INSULIN-RESISTANCE; GUT MICROBIOTA; OMEGA-3-FATTY-ACIDS; METAANALYSIS;
   ANTIDEPRESSANT; INFLAMMATION; DEPRESSION; PROBIOTICS; DISORDERS; DEXTRIN
AB This trial evaluated the effects of co-supplementing Camelina sativa oil (CSO) and a prebiotic as modulators of the gut microbiota on cardiometabolic risk factors and mental health in NAFLD patients. In all, 44 subjects with NAFLD were allocated to either an intervention (20 g d(-1) CSO + resistant dextrin) or a placebo (20 g d(-1) CSO + maltodextrin) group and received a calorie-restricted diet (-500 kcal d(-1)) for 12 weeks. Fasting plasma levels of gucose, insulin, hs-CRP, endotoxin, antioxidant enzyme activity, total antioxidant capacity (TAC), malondialdehyde (MDA), 8-iso-prostaglandin F2 alpha, and uric acid were measured at the baseline and post-intervention. The depression, anxiety and stress scale (DASS) and the general health questionnaire (GHQ) were used to assess mental health. Co-supplementing CSO and resistant dextrin significantly decreased the level of insulin concentration (-0.84 mu U ml(-1), p = 0.011), HOMA-IR (-0.27, p = 0.021), hs-CRP (-1.25 pg ml(-1), p = 0.023), endotoxin (-3.70 EU mL(-1), p = 0.001), cortisol (-2.43, p = 0.033), GHQ (-5.03, p = 0.035), DASS (-9.01, p = 0.024), and MDA (-0.54 nmol mL(-1), p = 0.021) and increased the levels of TAC (0.16 mmol L-1, p = 0.032) and superoxide dismutase (106.32 U g(-1) Hb, p = 0.45) in the intervention group compared with the placebo group. No significant changes were observed in the levels of other biomarkers. Co-supplementing CSO and resistant dextrin in combination with a low-calorie diet may improve metabolic risk factors and mental health in NAFLD patients.
C1 [Kavyani, Maryam] Tabriz Univ Med Sci, Fac Nutr & Food Sci, Student Res Comm, Tabriz, Iran.
   [Saleh-Ghadimi, Sevda; Dehghan, Parvin; Abbasalizad Farhangi, Mahdieh] Tabriz Univ Med Sci, Fac Nutr & Food Sci, Nutr Res Ctr, Tabriz, Iran.
   [Abbasalizad Farhangi, Mahdieh] Tabriz Univ Med Sci, Drug Appl Res Ctr, Tabriz, Iran.
   [Khoshbaten, Manouchehr] Tabriz Univ Med Sci, Liver & Gastrointestinal Dis Res Ctr, Tabriz, Iran.
C3 Tabriz University of Medical Science; Tabriz University of Medical
   Science; Tabriz University of Medical Science; Tabriz University of
   Medical Science
RP Dehghan, P; Farhangi, MA (corresponding author), Tabriz Univ Med Sci, Fac Nutr & Food Sci, Nutr Res Ctr, Tabriz, Iran.; Farhangi, MA (corresponding author), Tabriz Univ Med Sci, Drug Appl Res Ctr, Tabriz, Iran.
EM dehghan.nut@gmail.com; abbasalizad_m@yahoo.com
RI Saleh-Ghadimi, Sevda/ABD-2355-2021; Farhangi, Mahdieh/AAC-6758-2019;
   Dehghan, Parvin/G-3885-2015
OI Dehghan, Parvin/0000-0001-8929-3302
FU Nutrition Research Center [63935]; TBZMED, Iran
FX The present study was supported by the Nutrition Research Center and the
   Vice Chancellor of Research of TBZMED, Iran. This article was written
   based on the data obtained from the M.Sc. thesis of Kavyani M from the
   Nutrition Research Center (grant number: 63935).
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PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PD SEP 21
PY 2021
VL 12
IS 18
BP 8594
EP 8604
DI 10.1039/d1fo00448d
EA JUN 2021
PG 11
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA US9CL
UT WOS:000680093400001
PM 34338703
DA 2025-06-11
ER

PT J
AU Puttonen, S
   Keltikangas-Järvinen, L
   Ravaja, N
   Viikari, J
AF Puttonen, S
   Keltikangas-Järvinen, L
   Ravaja, N
   Viikari, J
TI Affects and autonomic cardiac reactivity during experimentally induced
   stress as related to precursors of insulin resistance syndrome
SO INTERNATIONAL JOURNAL OF BEHAVIORAL MEDICINE
LA English
DT Article
DE insulin resistance syndrome; stress; emotion; heart rate; pre-ejection
   period; respiratory sinus arrhythmia
ID METABOLIC SYNDROME PRECURSORS; CARDIOVASCULAR RISK; HEART-RATE; FAT
   DISTRIBUTION; BLOOD-PRESSURE; SERUM-LIPIDS; YOUNG-ADULTS; CHILDREN;
   ADOLESCENTS; PERSONALITY
AB This study examined the association of insulin resistance syndrome (IRS) precursors with state affects and autonomic reactivity in randomly selected healthy young adults. It was asked whether IRS precursors are able to predict a person's mental and physiological coping with acute stress over an 11-year follow-up period. IRS parameters were serum insulin, high-density lipoprotein cholesterol, triglycerides, systolic blood pressure, body-mass index, and subscapular skinfold thickness. In the psychophysiological experiment, state affects and cardiac responses (heart rate, respiratory sinus arrhythmia, and pre-ejection period) were measured during different challenges. The main result was that IRS precursors predicted high levels of negative emotions during the challenges; IRS accounted for 19% of the variance in tiredness. IRS was unrelated to cardiac reactivity. Mechanisms underlying the associations found are discussed.
C1 Univ Helsinki, Dept Psychol, FIN-00014 Helsinki, Finland.
   Univ Turku, Dept Med, Turku, Finland.
C3 University of Helsinki; University of Turku
EM Liisa.Keltikangas-Jarvinen@helsinki.fi
RI ; Ravaja, Niklas/D-1532-2013
OI Puttonen, Sampsa/0000-0002-7796-6941; Ravaja, Niklas/0000-0003-1876-8731
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NR 62
TC 3
Z9 4
U1 0
U2 8
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1070-5503
EI 1532-7558
J9 INT J BEHAV MED
JI Int. J. Behav. Med.
PY 2003
VL 10
IS 2
BP 106
EP 124
DI 10.1207/S15327558IJBM1002_02
PG 19
WC Psychology, Clinical
WE Social Science Citation Index (SSCI)
SC Psychology
GA 688RZ
UT WOS:000183450900002
PM 12763705
DA 2025-06-11
ER

PT J
AU Azzopardi, PS
   Willenberg, L
   Wulan, N
   Devaera, Y
   Medise, B
   Riyanti, A
   Ansariadi, A
   Sawyer, S
   Wiguna, T
   Kaligis, F
   Fisher, J
   Tran, T
   Agius, PA
   Borschmann, R
   Brown, A
   Cini, K
   Clifford, S
   Kennedy, EC
   Pedrana, A
   Pham, MD
   Wake, M
   Zimmet, P
   Durrant, K
   Wiweko, B
   Luchters, S
AF Azzopardi, Peter S.
   Willenberg, Lisa
   Wulan, Nisaa
   Devaera, Yoga
   Medise, Bernie
   Riyanti, Aida
   Ansariadi, Ansariadi
   Sawyer, Susan
   Wiguna, Tjhin
   Kaligis, Fransiska
   Fisher, Jane
   Tran, Thach
   Agius, Paul A.
   Borschmann, Rohan
   Brown, Alex
   Cini, Karly
   Clifford, Susan
   Kennedy, Elissa C.
   Pedrana, Alisa
   Pham, Minh D.
   Wake, Melissa
   Zimmet, Paul
   Durrant, Kelly
   Wiweko, Budi
   Luchters, Stanley
TI Direct assessment of mental health and metabolic syndrome amongst
   Indonesian adolescents: a study design for a mixed-methods study sampled
   from school and community settings
SO GLOBAL HEALTH ACTION
LA English
DT Article
DE Study design; objective assessment; mental disorder; metabolic syndrome;
   adolescents; school-based; community-based; Indonesia
ID STUDIES DEPRESSION SCALE; SYSTEMATIC ANALYSIS; GLOBAL BURDEN;
   ASSOCIATION; RELIABILITY; VALIDATION; INJURIES; CHILDREN; VALIDITY;
   STUDENTS
AB Non-communicable diseases (NCDs) are the leading cause of morbidity and mortality globally, with the burden largely borne by people living in low- and middle-income countries. Adolescents are central to NCD control through the potential to modify risks and alter the trajectory of these diseases across the life-course. However, an absence of epidemiological data has contributed to the relative exclusion of adolescents from policies and responses. This paper documents the design of a study to measure the burden of metabolic syndrome (a key risk for NCDs) and poor mental health (a key outcome) amongst Indonesian adolescents. Using a mixed-method design, we sampled 16-18-year-old adolescents from schools and community-based settings across Jakarta and South Sulawesi. Initial formative qualitative enquiry used focus group discussions to understand how young people conceptualise mental health and body weight (separately); what they perceive as determinants of these NCDs; and what responses to these NCDs should involve. These findings informed the design of a quantitative survey that adolescents self-completed electronically. Mental health was measured using the Centre for Epidemiologic Studies Depression Scale-Revised (CESD-R) and Kessler-10 (both validated against formal psychiatric interview in a subsample), with the metabolic syndrome measured using biomarkers and anthropometry. The survey also included scales relating to victimisation, connectedness, self-efficacy, body image and quality of life. Adolescents were sampled from schools using a multistage cluster design, and from the community using respondent-driven sampling (RDS). This study will substantially advance the field of NCD measurement amongst adolescents, especially in settings like Indonesia. It demonstrates that high quality, objective measurement is acceptable and feasible, including the collection of biomarkers in a school-based setting. It demonstrates how comparable data can be collected across both in-school and out of school adolescents, allowing a more comprehensive measure of NCD burden, risk and correlates.
C1 [Azzopardi, Peter S.; Willenberg, Lisa; Wulan, Nisaa; Cini, Karly; Kennedy, Elissa C.] Burnet Inst, Maternal Child & Adolescent Hlth Program, Global Adolescent Hlth Grp, Melbourne, Vic, Australia.
   [Azzopardi, Peter S.; Sawyer, Susan; Clifford, Susan] Univ Melbourne, Royal Childrens Hosp, Dept Paediat, Melbourne, Vic, Australia.
   [Azzopardi, Peter S.; Brown, Alex] South Australian Hlth & Med Res Inst, Aboriginal Hlth Equ Theme, Adelaide, SA, Australia.
   [Azzopardi, Peter S.; Sawyer, Susan; Cini, Karly; Clifford, Susan; Wake, Melissa] Murdoch Childrens Res Inst, Populat Hlth Grp, Melbourne, Vic, Australia.
   [Devaera, Yoga; Medise, Bernie] Univ Indonesia, Dept Child Hlth, Jakarta, Indonesia.
   [Riyanti, Aida] Univ Indonesia, Fac Med, Dept Obstet & Gynaecol, Jakarta, Indonesia.
   [Ansariadi, Ansariadi] Univ Hasanuddin, Sch Publ Hlth, Dept Epidemiol, Makassar, Indonesia.
   [Wiguna, Tjhin; Kaligis, Fransiska] Univ Indonesia, Fac Med, Dept Psychiat, Jakarta, Indonesia.
   [Fisher, Jane; Tran, Thach] Monash Univ, Sch Populat & Prevent Med, Global & Womens Hlth Unit, Melbourne, Vic, Australia.
   [Agius, Paul A.; Durrant, Kelly; Luchters, Stanley] Burnet Inst, Maternal Child & Adolescent Hlth Program, Melbourne, Vic, Australia.
   [Borschmann, Rohan] Univ Melbourne, Ctr Hlth Equ, Melbourne Sch Populat & Global Hlth, Justice Hlth Unit, Melbourne, Vic, Australia.
   [Pedrana, Alisa; Pham, Minh D.] Burnet Inst, Dis Eliminat Program, Melbourne, Vic, Australia.
   [Zimmet, Paul] Monash Univ, Cent Clin Sch, Dept Diabet, Melbourne, Vic, Australia.
   [Wiweko, Budi] Univ Indonesia, Fac Med, Res & Social Serv, Jakarta, Indonesia.
   [Agius, Paul A.; Kennedy, Elissa C.; Pham, Minh D.] Monash Univ, Dept Epidemiol & Preventat Med, Melbourne, Vic, Australia.
C3 Burnet Institute; University of Melbourne; Royal Children's Hospital
   Melbourne; South Australian Health & Medical Research Institute
   (SAHMRI); Murdoch Children's Research Institute; University of
   Indonesia; University of Indonesia; Universitas Hasanuddin; University
   of Indonesia; Monash University; Burnet Institute; University of
   Melbourne; Burnet Institute; Monash University; University of Indonesia;
   Monash University
RP Azzopardi, PS (corresponding author), Burnet Inst, Global Adolescent Hlth Grp, 85 Commercial Rd, Melbourne, Vic 3004, Australia.
EM peter.azzopardi@burnet.edu.au
RI Pham, Minh/H-9632-2012; Zimmet, Paul/H-7635-2013; Agius,
   Paul/I-4001-2019; Cini, Karly/KMA-1173-2024; Brown, Alex/E-8614-2010;
   Kaligis, Fransiska/MGU-4109-2025; azzopardi, peter/J-7355-2012; Fisher,
   Jane/I-1569-2014; Borschmann, Rohan/A-7954-2011; Tran,
   Thach/H-7734-2014; Wake, Melissa/J-1396-2012
OI Tran, Thach/0000-0002-4686-8601; Sawyer, Susan/0000-0002-9095-358X;
   Brown, Alex/0000-0003-2112-3918; Luchters, Stanley/0000-0001-5235-5629;
   Wake, Melissa/0000-0001-7501-9257; Pedrana, Alisa/0000-0002-1998-5722;
   Agius, Paul/0000-0002-6075-8548; Cini, Karly/0000-0002-1365-704X;
   Ansariadi, Ansariadi/0000-0002-9692-6136; Pham, Minh
   D./0000-0002-5932-3491; Medise, Bernie/0000-0001-7494-7238; Kaligis,
   Fransiska/0000-0003-3776-7064; azzopardi, peter/0000-0002-9280-6997;
   Devaera, Yoga/0000-0002-5427-9823; Wiguna, Tjhin/0000-0002-7524-5868
FU Health Cluster of the Australian-Indonesia Centre; National Health and
   Medical Research Council Early Career Fellowship; Finkel Family
   Foundation
FX This study was commissioned and funded by the Health Cluster of the
   Australian-Indonesia Centre. The funding body did not have any impact on
   the collection, analysis, or interpretation of data or on the writing of
   this manuscript. Peter S. Azzopardi and Thach Tran both hold a National
   Health and Medical Research Council Early Career Fellowship. Jane Fisher
   is funded by a Professorial Fellowship from the Finkel Family
   Foundation.
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NR 51
TC 8
Z9 8
U1 0
U2 179
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
EI 1654-9880
J9 GLOBAL HEALTH ACTION
JI Glob. Health Action
PD DEC 31
PY 2020
VL 13
IS 1
AR 1732665
DI 10.1080/16549716.2020.1732665
PG 14
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA LD3SY
UT WOS:000525953700001
PM 32174255
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Srichomphu, P
   Wattanathorn, J
   Thukham-mee, W
   Muchimapura, S
AF Srichomphu, Pratthana
   Wattanathorn, Jintanaporn
   Thukham-mee, Wipawee
   Muchimapura, Supaporn
TI Anxiety, Insomnia, and Memory Impairment in Metabolic Syndrome Rats Are
   Alleviated by the Novel Functional Ingredients from Anacardium
   occidentale
SO ANTIOXIDANTS
LA English
DT Article
DE anxiety; insomnia; memory; Anacardium occidentale; metabolic syndrome
ID ELEVATED PLUS-MAZE; OXIDATIVE STRESS; MONOAMINE-OXIDASE; COGNITIVE
   IMPAIRMENT; ALZHEIMERS-DISEASE; IN-VITRO; DEPRESSION; DISORDERS; SLEEP;
   GABA
AB Despite an increase in the coexistence of metabolic syndrome (MetS) and psychological disorders, together with their great impact on socio-economic burdens, no protective strategies that focus on these situations are available. Due to the role of oxidative stress in the pathophysiology of metabolic syndrome (MetS) and psychological disorders, we hypothesized that substances possessing antioxidant activity such as the novel functional ingredients from Anacardium occidentale (AO) could mitigate common psychological disorders in MetS rats. Male Wistar rats, weighing 200-250 g, were induced with MetS through a 12-week high-fat and high-cholesterol diet (HFHC). Then, they were given AO orally via a gastric gavage needle at doses of 1, 10 and 100 mg/kg BW for 14 days. Spatial memory, anxiety, depression, and sleep behaviors, together with changes in oxidative stress status and neurotransmitters, were assessed. All doses of AO significantly improved memory, anxiety, and sleep, together with the suppression of oxidative stress, AChE, and GABA-T in the cerebral cortex and hippocampus. These results suggest the protective effect of AO against anxiety, insomnia, and memory impairment that coexist with the MetS condition via an improvement in oxidative stress and the functions of the cholinergic and GABAergic systems. However, this benefit requires clinical confirmation.
C1 [Srichomphu, Pratthana] Khon Kaen Univ, Fac Med, Dept Physiol, Khon Kaen 40002, Thailand.
   [Srichomphu, Pratthana] Khon Kaen Univ, Fac Med, Grad Sch, Neurosci Program, Khon Kaen 40002, Thailand.
   [Wattanathorn, Jintanaporn; Thukham-mee, Wipawee; Muchimapura, Supaporn] Khon Kaen Univ, Res Inst High Human Performance & Hlth Promot, Khon Kaen 40002, Thailand.
C3 Khon Kaen University; Khon Kaen University; Khon Kaen University
RP Wattanathorn, J (corresponding author), Khon Kaen Univ, Res Inst High Human Performance & Hlth Promot, Khon Kaen 40002, Thailand.
EM jinwat05@gmail.com
OI Muchimapura, Supaporn/0000-0001-7756-1955; Thukhammee,
   Wipawee/0000-0001-6923-396X; Wattanathorn,
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NR 87
TC 5
Z9 5
U1 1
U2 9
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD NOV
PY 2022
VL 11
IS 11
AR 2203
DI 10.3390/antiox11112203
PG 23
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA 6U4OK
UT WOS:000894347800001
PM 36358575
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Apostolopoulos, V
   Borkoles, E
   Polman, R
   Stojanovska, L
AF Apostolopoulos, Vasso
   Borkoles, Erika
   Polman, Remco
   Stojanovska, Lily
TI Physical and immunological aspects of exercise in chronic diseases
SO IMMUNOTHERAPY
LA English
DT Review
DE cancer; chronic diseases; exercise; immune status; immunity;
   immunotherapy; inflammation; physical activity
ID PERIPHERAL-BLOOD COMPARTMENT; DEPRESSION-LIKE BEHAVIOR; SENESCENT
   T-LYMPHOCYTES; QUALITY-OF-LIFE; CARDIOVASCULAR-DISEASE; METABOLIC
   SYNDROME; AEROBIC EXERCISE; OXIDATIVE STRESS; MULTIPLE-SCLEROSIS;
   BREAST-CANCER
AB Physical inactivity and sedentary lifestyles are believed to be independent risk factors for the occurrence of numerous diseases, including, obesity, Type 2 diabetes, metabolic syndrome, cardiovascular disease, cancer and mental health, all leading to substantial morbidity and/or premature death. It has been found that regular exercise, is associated with better quality of life and health outcomes, and reduces the risk of cardiovascular disease and cancer. Here, we review the effects regular exercise has on mental health and well-being, on the immune system and in cancer, cardiovascular disease, autoimmunity and metabolic syndrome. Is exercise the new immunotherapy to treat diseases?
C1 [Apostolopoulos, Vasso; Stojanovska, Lily] Victoria Univ, Ctr Chron Dis Prevent & Management, Coll Hlth & Biomed, Melbourne, Vic 8001, Australia.
   [Apostolopoulos, Vasso] VA Consulting Serv, Melbourne, Vic 3030, Australia.
   [Borkoles, Erika; Polman, Remco] Victoria Univ, Coll Sport & Exercise Sci, Melbourne, Vic 8001, Australia.
C3 Victoria University; Victoria University
RP Apostolopoulos, V (corresponding author), Victoria Univ, Ctr Chron Dis Prevent & Management, Coll Hlth & Biomed, POB 14428, Melbourne, Vic 8001, Australia.
EM vasso@scientist.com
RI Apostolopoulos, Vasso/Q-4525-2019; Borkoles, Erika/M-8802-2019; Polman,
   Remco/D-1877-2013; Borkoles, Erika/N-1950-2013
OI Polman, Remco/0000-0003-2951-0904; Borkoles, Erika/0000-0002-7807-8890;
   Apostolopoulos, Vasso/0000-0001-6788-2771; Stojanovska,
   Lily/0000-0001-7186-4461
FU Australian Government's Collaborative Research Networks (CRN) program
FX DE Borkoles' work is supported through the Australian Government's
   Collaborative Research Networks (CRN) program. The authors have no other
   relevant affiliations or financial involvement with any organization or
   entity with a financial interest in or financial conflict with the
   subject matter or materials discussed in the manuscript apart from those
   disclosed.
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NR 123
TC 35
Z9 36
U1 2
U2 40
PU FUTURE MEDICINE LTD
PI LONDON
PA UNITEC HOUSE, 3RD FLOOR, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON, N3
   1QB, ENGLAND
SN 1750-743X
EI 1750-7448
J9 IMMUNOTHERAPY-UK
JI Immunotherapy
PY 2014
VL 6
IS 10
BP 1145
EP 1157
DI 10.2217/IMT.14.76
PG 13
WC Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology
GA AU5LK
UT WOS:000345648300011
PM 25428651
OA Green Submitted, Green Accepted
DA 2025-06-11
ER

PT J
AU Cavicchioli, FL
   Maes, M
   Roomruangwong, C
   Bonifacio, KL
   Barbosa, DS
   Anderson, G
   Vargas, HO
   Nunes, SOV
AF Cavicchioli, Fernanda Liboni
   Maes, Michael
   Roomruangwong, Chutima
   Bonifacio, Kandla Landucci
   Barbosa, Decio Sabbatini
   Anderson, George
   Vargas, Heber Odebrecht
   Vargas Nunes, Sandra Odebrecht
TI Associations between severity of anxiety and clinical and biological
   features of major affective disorders
SO PSYCHIATRY RESEARCH
LA English
DT Article
DE Bipolar disorder; Depressive disorder; Anxiety disorders; Comorbidity;
   HDL-cholesterol; Metabolic syndrome; Lithium
ID POSTTRAUMATIC-STRESS-DISORDER; CHILDHOOD-TRAUMA; METABOLIC SYNDROME;
   PSYCHIATRIC-DISORDERS; NICOTINE DEPENDENCE; PORTUGUESE VERSION; BIPOLAR
   DISORDER; MENTAL-ILLNESS; SEXUAL-ABUSE; RATING-SCALE
AB Patients with major affective disorders (MAFD) with comorbid anxiety show a greater functional impairment than those without anxiety. The aim of this study is to delineate the associations between severity of anxiety in MAFD, namely bipolar disorder (BD) and major depression (MOD), and MAFD characteristics and serum high density lipoprotein (HDL)-cholesterol levels. Recruited were 82 participants with anxiety disoders and 83 without anxiety disoders, including 101 MAFD patients and 51 healthy controls. We used the Hamilton Anxiety Rating Scale (HAM-A) to measure severity of anxiety and made the diagnoses of posttraumatic stress disorder (PTSD), obsessive compulsive disorder (OCD), panic disorder (PD), generalized anxiety disorder (GAD) and phobias. The HAM-A score is significantly predicted by higher number of depressive episodes, GAD and phobias, childhood trauma, tobacco use disorder, metabolic syndrome and lowered HDL-cholesterol. Increased HAM-A scores are, independently from severity of depression, associated with lowered quality of life, increased disabilities and suicidal ideation. Lithium treatment significantly lowers HAM-A scores. It is concluded that severity of anxiety significantly worsens the phenomenology of MAFD. Therefore, treatments of MAFD should target increased severity of anxiety and its risk factors including low HDL-cholesterol, metabolic syndrome, childhood trauma and tobacco use disorder.
C1 [Cavicchioli, Fernanda Liboni; Maes, Michael; Bonifacio, Kandla Landucci; Barbosa, Decio Sabbatini; Vargas, Heber Odebrecht; Vargas Nunes, Sandra Odebrecht] Univ Estadual Londrina, Hlth Sci Ctr, Hlth Sci Grad Program, Londrina, Brazil.
   [Maes, Michael; Roomruangwong, Chutima] Chulalongkorn Univ, Dept Psychiat, Bangkok, Thailand.
   [Maes, Michael] Deakin Univ, Impact Strateg Res Ctr, Geelong, Vic, Australia.
   [Maes, Michael] Med Univ Plovdiv, Dept Psychiat, Plovdiv, Bulgaria.
   [Anderson, George] CRC, Carnoustie, Scotland.
   [Anderson, George] CRC, London, England.
C3 Universidade Estadual de Londrina; Chulalongkorn University; Deakin
   University; Medical University Plovdiv
RP Maes, M (corresponding author), Deakin Univ, Barwon Hlth, IMPACT Strateg Res Ctr, Geelong, Vic, Australia.
EM dr.michaelmaes@hotmail.com
RI Barbosa, Décio/AAE-6351-2019; Roomruangwong, Chutima/L-1317-2019; Maes,
   Michael/B-8546-2011; Anderson, George/AEO-3626-2022
OI Maes, Michael/0000-0002-2012-871X; Anderson, George/0000-0001-7243-0817
FU Ministry of Science and Technology (CNPq) [470344/2013-0,
   465928/2014-5]; CNPq
FX This study was supported by grants from the Ministry of Science and
   Technology (CNPq 470344/2013-0 and 465928/2014-5). MM is supported by an
   international researcher visitor fellowship from CNPq to the Health
   Sciences Graduate Program. SOVN and DSB are senior fellows from Fundacao
   Araucaria.
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NR 70
TC 16
Z9 18
U1 1
U2 16
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0165-1781
EI 1872-7123
J9 PSYCHIAT RES
JI Psychiatry Res.
PD FEB
PY 2018
VL 260
BP 17
EP 23
DI 10.1016/j.psychres.2017.11.024
PG 7
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA FV8RU
UT WOS:000424855300003
PM 29156296
DA 2025-06-11
ER

PT J
AU Li, CC
   Tao, TQ
   Tang, YY
   Lu, HM
   Zhang, HF
   Li, HX
   Liu, XH
   Guan, WP
   Niu, YX
AF Li, Cancan
   Tao, Tianqi
   Tang, Yanyan
   Lu, Huimin
   Zhang, Hongfeng
   Li, Huixin
   Liu, Xiuhua
   Guan, Weiping
   Niu, Yixuan
TI The association of psychological stress with metabolic syndrome and its
   components: cross-sectional and bidirectional two-sample Mendelian
   randomization analyses
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Article
DE metabolic syndrome; psychological stress; hypertension; risk factor;
   cross-sectional study; Mendelian randomization analysis
ID SLEEP QUALITY INDEX; PERCEIVED STRESS; SALIVARY CORTISOL; OBESITY; WORK;
   INSTRUMENT; RISK; HYPERTENSION; DEPRESSION; VERSION
AB BackgroundMetabolic syndrome (MetS) is a group of co-occurring conditions that increase the risk of cardiovascular disease, which include the conditions of hypertension, overweight or obesity, hyperglycemia, and dyslipidemia. Psychological stress is gradually being taken seriously, stemming from the imbalance between environmental demands and individual perceptions. However, the potential causal relationship between psychological stress and MetS remains unclear.MethodWe conducted cross-sectional and bidirectional Mendelian randomization (MR) analyses to clarify the potential causal relationship of psychological stress with MetS and its components. Multivariable logistic regression models were used to adjust for potential confounders in the cross-sectional study of the Chinese population, including 4,933 individuals (70.1% men; mean age, 46.13 +/- 8.25). Stratified analyses of sexual characteristics were also performed. Bidirectional MR analyses were further carried out to verify causality based on summary-level genome-wide association studies in the European population, using the main analysis of the inverse variance-weighted method.ResultsWe found that higher psychological stress levels were cross-sectionally associated with an increased risk of hypertension in men (odds ratio (OR), 1.341; 95% confidence interval (CI), 1.023-1.758; p = 0.034); moreover, higher levels of hypertension were cross-sectionally associated with an increased risk of psychological stress in men and the total population (men: OR, 1.545 (95% CI, 1.113-2.145); p = 0.009; total population: OR, 1.327 (95% CI, 1.025-1.718); p = 0.032). Genetically predicted hypertension was causally associated with a higher risk of psychological stress in the inverse-variance weighted MR model (OR, 2.386 (95% CI, 1.209-4.710); p = 0.012). However, there was no association between psychological stress and MetS or the other three risk factors (overweight or obesity, hyperglycemia, and dyslipidemia) in cross-sectional and MR analyses.ConclusionAlthough we did not observe an association between psychological stress and MetS, we found associations between psychological stress and hypertension both in cross-sectional and MR studies, which may have implications for targeting hypertension-related factors in interventions to improve mental and metabolic health. Further study is needed to confirm our findings.
C1 [Li, Cancan; Lu, Huimin] Capital Med Univ, Sch Publ Hlth, Beijing Key Lab Clin Epidemiol, Beijing, Peoples R China.
   [Tao, Tianqi; Tang, Yanyan; Zhang, Hongfeng; Li, Huixin; Liu, Xiuhua; Guan, Weiping; Niu, Yixuan] Chinese Peoples Liberat Army Gen Hosp, Med Ctr 2, Natl Clin Res Ctr Geriatr Dis, Dept Geriatr, Beijing, Peoples R China.
C3 Capital Medical University; Chinese People's Liberation Army General
   Hospital
RP Guan, WP; Niu, YX (corresponding author), Chinese Peoples Liberat Army Gen Hosp, Med Ctr 2, Natl Clin Res Ctr Geriatr Dis, Dept Geriatr, Beijing, Peoples R China.
EM guanweiping@126.com; niuyx2003@126.com
RI Lu, Huimin/H-5571-2011
FU National Key R&D Programme of China [2017YFE0118800]; National Natural
   Science Foundation of China [82100265, 31971049]
FX The author(s) declare financial support was received for the research,
   authorship, and/or publication of this article. This project was
   supported by the National Key R&D Programme of China (2017YFE0118800)
   and the National Natural Science Foundation of China (No. 82100265, No.
   31971049).
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U1 0
U2 11
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD DEC 8
PY 2023
VL 14
AR 1212647
DI 10.3389/fendo.2023.1212647
PG 14
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA DA4W4
UT WOS:001129309700001
PM 38144566
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Sun, MJ
   Jang, MH
AF Sun, Min Jung
   Jang, Mi Heui
TI Risk Factors of Metabolic Syndrome in Community-Dwelling People with
   Schizophrenia
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Article
DE schizophrenia; metabolic syndrome; lifestyle; depression; social support
ID HEALTH BEHAVIOR-CHANGE; SOCIAL SUPPORT; PHYSICAL-ACTIVITY;
   MENTAL-HEALTH; DEPRESSIVE SYMPTOMS; DIETARY HABITS; BLOOD-PRESSURE;
   PREVALENCE; ANTIPSYCHOTICS; ASSOCIATION
AB This study investigated the prevalence and risk factors of metabolic syndrome in 100 community-dwelling people with schizophrenia registered in mental health facilities in Seoul, Korea. This study was conducted between 12 September and 15 November 2019. This study used a cross-sectional descriptive design. The data included were general and disease-related characteristics, diagnostic tests for metabolic syndrome, lifestyles, depression, and social support. The analysis of collected data was done by using the SPSS 24.0 program. The prevalence of metabolic syndrome was 42.0%. Higher body mass index (odds ratio [OR] = 1.60, 95% CI = 1.16-2.18,p= 0.004), and depression (OR = 1.22, 95% CI = 1.06-1.42,p= 0.008) were associated with higher risks of metabolic syndrome, while physical activity and weight control (OR = 0.71, 95% CI = 0.54-0.94,p= 0.018), dietary habits (OR = 0.72, 95% CI = 0.54-0.93,p= 0.011), and medication and health management (OR = 0.52, 95% CI = 0.31-0.86,p= 0.012) were associated with lower risks. Mental health care nurses need to recognize the high prevalence of metabolic syndrome in people with schizophrenia in the community and provide differentiated, customized lifestyle improvement programs based on the body mass index and depression status of each person with schizophrenia. Furthermore, comprehensive lifestyle improvement programs and health examination services that people with schizophrenia can easily adhere to should be developed.
C1 [Sun, Min Jung; Jang, Mi Heui] Kyung Hee Univ, Coll Nursing Sci, Seoul 02447, South Korea.
C3 Kyung Hee University
RP Jang, MH (corresponding author), Kyung Hee Univ, Coll Nursing Sci, Seoul 02447, South Korea.
EM dnfntk0213@khu.ac.kr; mhjang@khu.ac.kr
RI Jang, Mi/AAI-8528-2020; Stefanadis, Christodoulos/ABH-2232-2020
OI , Min-Jung/0000-0003-3998-2286; Jang, Mi Heui/0000-0002-5645-4816;
   Stefanadis, Christodoulos/0000-0001-5974-6454
FU Seoul Nurses Association's Hanmaum Scholarship
FX This research was funded by the Seoul Nurses Association's Hanmaum
   Scholarship for 2019.
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NR 53
TC 15
Z9 15
U1 1
U2 12
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD SEP
PY 2020
VL 17
IS 18
AR 6700
DI 10.3390/ijerph17186700
PG 13
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA OE9DM
UT WOS:000580822100001
PM 32938011
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Pienaar, PR
   Roden, LC
   Boot, CRL
   van Mechelen, W
   Twisk, JWR
   Lambert, E
   Rae, DE
AF Pienaar, Paula R.
   Roden, Laura C.
   Boot, Cecile R. L.
   van Mechelen, Willem
   Twisk, Jos W. R.
   Lambert, Estelle, V
   Rae, Dale E.
TI Association between self-reported sleep duration and cardiometabolic
   risk in corporate executives
SO INTERNATIONAL ARCHIVES OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH
LA English
DT Article
DE Employees; Workplace; Health risk assessment; Sleep quantity; Short
   sleep
ID WORKING HOURS; DEPRESSION; STRESS; HEALTH; TIME; METAANALYSIS;
   MORTALITY; DASS-21; DISEASE; WORKERS
AB Purpose This cross-sectional study aimed to compare the association between self-reported sleep duration and cardiometabolic risk among men and women corporate executives and investigate potential lifestyle, work- and stress-related mediators thereof. Methods Self-reported sleep duration and lifestyle, occupational, psychological and measured anthropometrical, blood pressure (BP) and blood marker variables were obtained from health risk assessment data of 3583 corporate executives. Sex-stratified regression analyses investigated the relationships between occupational and psychological variables with self-reported sleep duration, and sleep duration with individual cardiometabolic risk factors. Mediation analyses investigated the effects of work, psychological and lifestyle factors on the relationships between self-reported sleep duration and cardiometabolic risk factors, as well as a continuous cardiometabolic risk score calculated from the sum of sex-stratified z-standardized scores of negative fasting serum HDL, and positive plasma Glu, serum TG, body mass index (BMI), waist circumference, systolic and diastolic BP. Results Longer work hours and work commute time, depression, anxiety and stress were associated with shorter sleep duration in both men and women (all p < 0.05). Shorter sleep duration was associated with higher BMI, larger waist circumference and greater cardiometabolic risk scores in both men and women (all p < 0.05), higher diastolic BP in men (p < 0.05) and lower HDL cholesterol in women (p < 0.05). Physical activity, working hours and stress significantly mediated the relationships between self-reported sleep duration and BMI, waist circumference, diastolic BP and cardiometabolic risk score in men only. Conclusion In these corporate executives, shorter self-reported sleep duration is associated with poorer psychological, occupational and cardiometabolic risk outcomes in both men and women. Given that physical activity, working hours and stress mediate this association among the men, the case for sleep health interventions in workplace health programmes is warranted.
C1 [Pienaar, Paula R.; Roden, Laura C.; van Mechelen, Willem; Lambert, Estelle, V; Rae, Dale E.] Univ Cape Town, Hlth Phys Act Lifestyle & Sport Res Ctr, Fac Hlth Sci, Cape Town, South Africa.
   [Pienaar, Paula R.; Roden, Laura C.; van Mechelen, Willem; Lambert, Estelle, V; Rae, Dale E.] Univ Cape Town, Fac Hlth Sci, Dept Human Biol, Div Exercise Sci & Sports Med, Cape Town, South Africa.
   [Roden, Laura C.] Coventry Univ, Fac Hlth & Life Sci, Sch Life Sci, Coventry CV1 2DS, W Midlands, England.
   [Pienaar, Paula R.; Boot, Cecile R. L.; van Mechelen, Willem] Vrije Univ Amsterdam, Amsterdam UMC, Dept Publ & Occupat Hlth, Van der Boechorststr 7, NL-1081 BT Amsterdam, Netherlands.
   [Pienaar, Paula R.; Boot, Cecile R. L.; van Mechelen, Willem] Vrije Univ Amsterdam, Amsterdam Publ Hlth Res Inst, Van der Boechorststr 7, NL-1081 BT Amsterdam, Netherlands.
   [Boot, Cecile R. L.] Radboud Univ Nijmegen, Behav Sci Inst BSI, Nijmegen, Netherlands.
   [van Mechelen, Willem] Univ Queensland, Fac Hlth & Behav Sci, Human Movement & Nutr Sci, Brisbane, Qld, Australia.
   [van Mechelen, Willem] Univ Coll Dublin, Sch Publ Hlth Physiotherapy & Populat Sci, Dublin, Ireland.
   [van Mechelen, Willem] Univ Groningen, Univ Med Ctr Groningen, Ctr Human Movement Sci, Groningen, Netherlands.
   [Twisk, Jos W. R.] Vrije Univ Amsterdam, Dept Epidemiol & Biostat, Amsterdam Publ Hlth Res Inst, Amsterdam Univ,Med Ctr, Amsterdam, Netherlands.
C3 University of Cape Town; University of Cape Town; Coventry University;
   Vrije Universiteit Amsterdam; University of Amsterdam; Vrije
   Universiteit Amsterdam; Radboud University Nijmegen; University of
   Queensland; University College Dublin; University of Groningen;
   University of Amsterdam; Vrije Universiteit Amsterdam
RP Pienaar, PR (corresponding author), Univ Cape Town, Hlth Phys Act Lifestyle & Sport Res Ctr, Fac Hlth Sci, Cape Town, South Africa.; Pienaar, PR (corresponding author), Univ Cape Town, Fac Hlth Sci, Dept Human Biol, Div Exercise Sci & Sports Med, Cape Town, South Africa.; Pienaar, PR (corresponding author), Vrije Univ Amsterdam, Amsterdam UMC, Dept Publ & Occupat Hlth, Van der Boechorststr 7, NL-1081 BT Amsterdam, Netherlands.; Pienaar, PR (corresponding author), Vrije Univ Amsterdam, Amsterdam Publ Hlth Res Inst, Van der Boechorststr 7, NL-1081 BT Amsterdam, Netherlands.
EM pnrpau001@myuct.ac.za
RI Rae, Dale/JAC-7553-2023; Roden, Laura/JBJ-1480-2023; van Mechelen,
   Willem/C-8463-2013; Roden, Laura Catherine/D-1364-2010; Lambert, Estelle
   Victoria/G-5738-2017; Rae, Dale/W-1039-2017
OI van Mechelen, Willem/0000-0001-7136-6382; Roden, Laura
   Catherine/0000-0002-1941-898X; Lambert, Estelle
   Victoria/0000-0003-4315-9153; Rae, Dale/0000-0002-2584-6585
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NR 55
TC 3
Z9 3
U1 0
U2 5
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0340-0131
EI 1432-1246
J9 INT ARCH OCC ENV HEA
JI Int. Arch. Occup. Environ. Health
PD NOV
PY 2021
VL 94
IS 8
BP 1809
EP 1821
DI 10.1007/s00420-021-01739-2
EA JUN 2021
PG 13
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA WB4KR
UT WOS:000668088300001
PM 34189625
OA Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Howard, R
   Kuhn, L
   Millar, F
   Street, M
AF Howard, Rebekah
   Kuhn, Lisa
   Millar, Freyja
   Street, Maryann
TI Physical health assessment and cardiometabolic monitoring practices
   across three adult mental health inpatient units - a retrospective
   cohort study
SO INTERNATIONAL JOURNAL OF MENTAL HEALTH NURSING
LA English
DT Article
DE adult; cardiometabolic monitoring; mental health; risk factors; waist
   circumference
ID NEW-ZEALAND COLLEGE; CLINICAL-PRACTICE GUIDELINES; METABOLIC SYNDROME;
   CONSENSUS STATEMENT; PSYCHOTIC DISORDERS; WAIST CIRCUMFERENCE;
   NATIONAL-SURVEY; NURSES VIEWS; PEOPLE; RISK
AB Australians with lived experience of mental illness die on average 10 or more years earlier than the general population. Cardiometabolic disorders, including cardiovascular disease and diabetes mellitus, are common causes of premature death in this cohort. Little is known about cardiometabolic monitoring practices in mental health inpatient units. The aim of this study was to examine the characteristics of cardiometabolic monitoring and physical health assessments of adult mental health consumers within the first 72 hours of admission to an inpatient unit. We implemented a retrospective descriptive exploratory design by medical record audit. Data were collected using a pre-validated audit tool, adapted with recent literature and policy, from a randomly selected sample of consumers admitted to three acute mental health adult inpatient units of a large Australian metropolitan health service in 2016. Of 228 consumers, the mean age was 37.5 (range 18-64) years and 51.3% were women. Cardiometabolic risks were common, yet most consumers received incomplete cardiometabolic monitoring. While few consumers (15%) were diagnosed with cardiometabolic comorbidities, 67.5% were prescribed psychotropic medications with high cardiometabolic risk. Compliance with recommended cardiometabolic monitoring varied considerably between risk factors: for example, blood pressure was measured in 56.1% of consumers, whereas waist circumference was never recorded. There were no statistically significant associations between cardiometabolic monitoring completion and sex or cardiometabolic risk. These findings demonstrate the need for increased education and awareness of cardiometabolic risk and identify a critical gap between physical health assessment practices and recommendations for this cohort.
C1 [Howard, Rebekah; Street, Maryann] Deakin Univ, Sch Nursing & Midwifery, Upton House,131 Thames St,Box Hill, Geelong, Vic 3128, Australia.
   [Howard, Rebekah] Eastern Hlth, Adult Mental Hlth Serv, Mooroolbark, Vic, Australia.
   [Kuhn, Lisa] Monash Univ, Sch Nursing & Midwifery, Clayton, Vic, Australia.
   [Millar, Freyja] Outcome Hlth, Melbourne, Vic, Australia.
   [Street, Maryann] Eastern Hlth Partnership, Ctr Qual & Patient Safety Res, Melbourne, Vic, Australia.
C3 Deakin University; Monash University
RP Howard, R (corresponding author), Deakin Univ, Sch Nursing & Midwifery, Upton House,131 Thames St,Box Hill, Geelong, Vic 3128, Australia.
EM Rebekah.Howard@easternhealth.org.au
RI Kuhn, Lisa/G-7181-2012; Street, Maryann/A-2709-2010
OI Millar, Freyja/0000-0002-4770-3200; Kuhn, Lisa/0000-0002-2421-2003;
   Street, Maryann/0000-0002-5615-141X; Howard, Rebekah/0000-0002-3834-3418
CR Alberti KGMM, 2006, DIABETIC MED, V23, P469, DOI 10.1111/j.1464-5491.2006.01858.x
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NR 53
TC 1
Z9 2
U1 0
U2 10
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1445-8330
EI 1447-0349
J9 INT J MENT HEALTH NU
JI Int. J. Ment. Health Nurs.
PD DEC
PY 2020
VL 29
IS 6
BP 1144
EP 1156
DI 10.1111/inm.12755
EA AUG 2020
PG 13
WC Nursing; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Psychiatry
GA OP4QB
UT WOS:000554480900001
PM 32743951
DA 2025-06-11
ER

PT J
AU Gawlik-Kotelnicka, O
   Skowronska, A
   Margulska, A
   Czarnecka-Chrebelska, KH
   Loniewski, I
   Skonieczna-Zydecka, K
   Strzelecki, D
AF Gawlik-Kotelnicka, Oliwia
   Skowronska, Anna
   Margulska, Aleksandra
   Czarnecka-Chrebelska, Karolina H.
   Loniewski, Igor
   Skonieczna-Zydecka, Karolina
   Strzelecki, Dominik
TI The Influence of Probiotic Supplementation on Depressive Symptoms,
   Inflammation, and Oxidative Stress Parameters and Fecal Microbiota in
   Patients with Depression Depending on Metabolic Syndrome
   Comorbidity-PRO-DEMET Randomized Study Protocol
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Article
DE depression; metabolic syndrome; probiotics; microbiota; inflammation;
   oxidative stress
ID POSTMYOCARDIAL INFARCTION DEPRESSION; LACTOBACILLUS-HELVETICUS R0052;
   BIFIDOBACTERIUM-LONGUM R0175; CHAIN FATTY-ACIDS; GUT MICROBIOTA;
   PSYCHOMETRIC PROPERTIES; CONSENSUS STATEMENT; RATING-SCALE;
   DOUBLE-BLIND; METAANALYSIS
AB There is a huge need to search for new treatment options and potential biomarkers of therapeutic response to antidepressant treatment. Depression and metabolic syndrome often coexist, while a pathophysiological overlap, including microbiota changes, may play a role. The paper presents a study protocol that aims to assess the effect of probiotic supplementation on symptoms of depression, anxiety and stress, metabolic parameters, inflammatory and oxidative stress markers, as well as fecal microbiota in adult patients with depressive disorders depending on the co-occurrence of metabolic syndrome. The trial will be a four-arm, parallel-group, prospective, randomized, double-blind, controlled design that will include 200 participants and will last 20 weeks (ClinicalTrials.gov identifier: NCT04756544). The probiotic preparation will contain Lactobacillus helveticus Rosell(R)-52, Bifidobacterium longum Rosell(R)-175. We will assess the level of depression, anxiety and stress, quality of life, blood pressure, body mass index and waist circumference, white blood cells count, serum levels of C-reactive protein, high-density lipoprotein (HDL) cholesterol, triglycerides, fasting glucose, fecal microbiota composition and the level of some fecal microbiota metabolites, as well as serum inflammatory markers and oxidative stress parameters. The proposed trial may establish a safe and easy-to-use adjunctive treatment option in a subpopulation of depressive patients only partially responsive to pharmacologic therapy.
C1 [Gawlik-Kotelnicka, Oliwia; Skowronska, Anna; Strzelecki, Dominik] Med Univ Lodz, Dept Affect & Psychot Disorders, PL-92216 Lodz, Poland.
   [Margulska, Aleksandra] Med Univ Lodz, Admiss Dept, Cent Teaching Hosp, PL-92216 Lodz, Poland.
   [Czarnecka-Chrebelska, Karolina H.] Med Univ Lodz, Dept Biomed & Genet, PL-92213 Lodz, Poland.
   [Loniewski, Igor; Skonieczna-Zydecka, Karolina] Pomeranian Med Univ, Dept Biochem Sci, PL-71460 Szczecin, Poland.
C3 Medical University Lodz; Medical University Lodz; Medical University
   Lodz; Pomeranian Medical University
RP Gawlik-Kotelnicka, O (corresponding author), Med Univ Lodz, Dept Affect & Psychot Disorders, PL-92216 Lodz, Poland.
EM oliwia.gawlik@umed.lodz.pl; anna.zabka@stud.umed.lodz.pl;
   aleksandra.margulska@gmail.com; karolina.czarnecka@umed.lodz.pl;
   sanprobi@sanprobi.pl; karzyd@pum.edu.pl; dominik.strzeledd@umed.lodz.pl
RI Gawlik-Kotelnicka, Oliwia/ITU-7979-2023; Strzelecki,
   Dominik/S-9340-2016; Gawlik-Kotelnicka, Oliwia/S-9936-2016;
   Czarnecka-Chrebelska, Karolina/C-8609-2011; Skonieczna-Zydecka,
   Karolina/K-7252-2014
OI Gawlik-Kotelnicka, Oliwia/0000-0003-1398-3117; Czarnecka-Chrebelska,
   Karolina/0000-0003-4013-513X; Margulska, Aleksandra/0000-0003-1229-0925;
   Skonieczna-Zydecka, Karolina/0000-0002-3430-9079; LONIEWSKI,
   IGOR/0000-0002-5398-4985; Strzelecki, Dominik/0000-0002-8559-1078
FU Medical University of Lodz
FX This research will be funded by the Medical University of Lodz, grant
   number 503/1-155-02/503-11-003-20. The APC was funded by the Medical
   University of Lodz.
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NR 93
TC 10
Z9 10
U1 3
U2 26
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD APR
PY 2021
VL 10
IS 7
AR 1342
DI 10.3390/jcm10071342
PG 20
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA RL0NR
UT WOS:000638681600001
PM 33804999
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Nousen, EK
   Franco, JG
   Sullivan, EL
AF Nousen, Elizabeth K.
   Franco, Juliana G.
   Sullivan, Elinor L.
TI Unraveling the Mechanisms Responsible for the Comorbidity between
   Metabolic Syndrome and Mental Health Disorders
SO NEUROENDOCRINOLOGY
LA English
DT Article
DE Obesity; Metabolic syndrome Diabetes; Schizophrenia; Bipolar disorder;
   Depression
ID ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; HEART-RATE-VARIABILITY;
   CORTICOTROPIN-RELEASING-FACTOR; HIGH-FAT DIET; TYPE-2 DIABETES-MELLITUS;
   NIGHT EATING SYNDROME; DOPAMINE TRANSPORTER BINDING; NUTRITION
   EXAMINATION SURVEY; RECEPTOR MESSENGER-RNA; 3RD NATIONAL-HEALTH
AB The increased prevalence and high comorbidity of metabolic syndrome (MetS) and mental health disorders (MHDs) have prompted investigation into the potential contributing mechanisms. There is a bidirectional association between MetS and MHDs including schizophrenia, bipolar disorder, depression, anxiety, attention-deficit/hyperactivity disorder, and autism spectrum disorders. Medication side effects and social repercussions are contributing environmental factors, but there are a number of shared underlying neurological and physiological mechanisms that explain the high comorbidity between these two disorders. Inflammation is a state shared by both disorders, and it contributes to disruptions of neuroregulatory systems (including the serotonergic, dopaminergic, and neuropeptide Y systems) as well as dysregulation of the hypothalamic-pituitary-adrenal axis. MetS in pregnant women also exposes the developing fetal brain to inflammatory factors that predispose the offspring to MetS and psychopathologies. Due to the shared nature of these conditions, treatment should address aspects of both mental health and metabolic disorders. Additionally, interventions that can interrupt the transfer of increased risk of the disorders to the next generation need to be developed. (C) 2013 S. Karger AG, Basel
C1 [Nousen, Elizabeth K.; Franco, Juliana G.; Sullivan, Elinor L.] Oregon Natl Primate Res Ctr, Div Diabet Obes & Metab, Beaverton, OR USA.
   [Sullivan, Elinor L.] Univ Portland, Dept Biol, Portland, OR 97203 USA.
C3 Oregon Health & Science University; Oregon National Primate Research
   Center; University of Portland
RP Sullivan, EL (corresponding author), Univ Portland, 5000 N Willamette Blvd, Portland, OR 97203 USA.
EM sullivae@up.edu
RI Sullivan, Elinor/AGS-1789-2022
OI Nousen, Elizabeth/0000-0002-2080-3367; Sullivan,
   Elinor/0000-0003-2630-8890
FU Murdock Charitable Trust; Murdock College Research Program for Life
   Science [2011273:HVP]; Oregon Clinical and Translational Research
   Institute (OCTRI) [UL1TR000128]; National Center for Advancing
   Translational Sciences (NCATS) at the National Institutes of Health
   (NIH)
FX This publication was supported by the Murdock Charitable Trust, Murdock
   College Research Program for Life Science, grant No. 2011273:HVP and
   Oregon Clinical and Translational Research Institute (OCTRI), grant No.
   (UL1TR000128) from the National Center for Advancing Translational
   Sciences (NCATS) at the National Institutes of Health (NIH). The content
   is solely the responsibility of the authors and does not necessarily
   represent the official views of the NIH.
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NR 247
TC 80
Z9 86
U1 1
U2 23
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 0028-3835
EI 1423-0194
J9 NEUROENDOCRINOLOGY
JI Neuroendocrinology
PY 2013
VL 98
IS 4
BP 254
EP 266
DI 10.1159/000355632
PG 13
WC Endocrinology & Metabolism; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology
GA AC3MW
UT WOS:000332426900002
PM 24080959
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Zimmer, AR
   Leonardi, BF
   Zimmer, ER
   Muller, AP
   Gosmann, G
   Portela, LVC
AF Zimmer, Aline Rigon
   Leonardi, Bianca Franco
   Zimmer, Eduardo Rigon
   Muller, Alexandre Pastoris
   Gosmann, Grace
   Portela, Luis Valmor Cruz
TI Capsicum baccatum Red Pepper Prevents Cardiometabolic Risk in
   Rats Fed with an Ultra-Processed Diet
SO METABOLITES
LA English
DT Article
DE Capsicum baccatum; cardiovascular risk; dyslipidemia; hyperglycemia;
   metabolic syndrome
ID CARDIOVASCULAR RISK; METABOLIC SYNDROME; INDUCED OBESITY;
   ADIPOSE-TISSUE; ANTIOXIDANT; SPICES; FLAVONOIDS; MANAGEMENT; ANXIETY;
   FOODS
AB Metabolic syndrome is a serious health condition reaching epidemic proportions worldwide and is closely linked to an increased risk of cardiovascular problems. The lack of appropriate treatment paves the way for developing new therapeutic agents as a high priority in the current research. In this study, we evaluated the protective effects of Capsicum baccatum red pepper on metabolic syndrome scenarios induced by an ultra-processed diet in rats. After four months, the ultra-processed diet increased central obesity, triglycerides, total cholesterol, LDL-cholesterol plasma levels, and impaired glucose tolerance. The oral administration of C. baccatum concomitantly with the ultra-processed diet avoided the accumulation of adipose tissue in the visceral region, reduced the total cholesterol and LDL fraction, and improved glucose homeostasis, factors commonly associated with metabolic syndrome. The data presented herein reveal an important preventive action of C. baccatum in developing metabolic disorders among animals fed a hypercaloric diet, significantly reducing their cardiometabolic risk. Allied with the absence of toxic effects after chronic use, our study suggests C. baccatum red pepper as a secure and enriched source of bioactive compounds promising to protect against pathological processes associated with metabolic syndrome.
C1 [Zimmer, Aline Rigon; Leonardi, Bianca Franco; Gosmann, Grace] Fed Univ Rio Grande Sul UFRGS, Fac Pharm, Pharmaceut Sci Grad Program PPGCF, BR-90610000 Porto Alegre, RS, Brazil.
   [Zimmer, Eduardo Rigon] Fed Univ Rio Grande Sul UFRGS, Dept Pharmacol, Grad Program Biol Sci Pharmacol & Therapeut PPGFT, BR-90035003 Porto Alegre, RS, Brazil.
   [Zimmer, Eduardo Rigon; Portela, Luis Valmor Cruz] Fed Univ Rio Grande Sul UFRGS, Dept Biochem, Grad Program Biol Sci Biochem PPGBioq, BR-90035003 Porto Alegre, RS, Brazil.
   [Muller, Alexandre Pastoris] Fed Univ Santa Catarina UFSC, Dept Biochem, BR-88037000 Florianopolis, SC, Brazil.
C3 Universidade Federal do Rio Grande do Sul; Universidade Federal do Rio
   Grande do Sul; Universidade Federal do Rio Grande do Sul
RP Zimmer, AR (corresponding author), Fed Univ Rio Grande Sul UFRGS, Fac Pharm, Pharmaceut Sci Grad Program PPGCF, BR-90610000 Porto Alegre, RS, Brazil.
EM aline.zimmer@ufrgs.br
RI Leonardi, Bianca/KIJ-7747-2024; Zimmer, Eduardo/I-2932-2015; Portela,
   Luis/I-3410-2014; Zimmer, Aline/A-3330-2016; Gosmann, Grace/G-3331-2012
OI Muller, alexandre/0000-0002-9961-8614; Franco Leonardi,
   Bianca/0000-0002-9777-9975
FU Brazilian Governmental Agencies Coordenacao de Aperfeicoamento de
   Pessoal de Nivel Superior-Brazil (CAPES) [001]; Conselho Nacional de
   Desenvolvimento Cientifico e Tecnologico (CNPq); Fundacao de Amparo a
   Pesquisa do Rio Grande do Sul (FAPERGS); PROEX-CAPES [0186/2022]
FX This study was funded by the Brazilian Governmental Agencies Coordenacao
   de Aperfeicoamento de Pessoal de Nivel Superior-Brazil (CAPES)-Finance
   Code 001; Conselho Nacional de Desenvolvimento Cientifico e Tecnologico
   (CNPq); and Fundacao de Amparo a Pesquisa do Rio Grande do Sul
   (FAPERGS). The APC was funded by PROEX-CAPES project number 0186/2022.
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NR 58
TC 0
Z9 0
U1 2
U2 6
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2218-1989
J9 METABOLITES
JI Metabolites
PD MAR
PY 2023
VL 13
IS 3
AR 385
DI 10.3390/metabo13030385
PG 15
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA C2DZ0
UT WOS:000960098100001
PM 36984825
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Mukherjee, A
   Banerjee, S
AF Mukherjee, A.
   Banerjee, S.
TI Effect of Metabolic Syndrome on Anxiety in Mice
SO INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES
LA English
DT Article
DE Anxiety; GABA; metabolic syndrome; obesity; type 2 diabetes
ID POSTTRAUMATIC-STRESS-DISORDER; GABA; MODEL; MOUSE; DIET; HYPERTENSION;
   FLUOXETINE; EXPRESSION; IMBALANCE; GLUTAMATE
AB Metabolic syndrome is a combination of obesity, dyslipidemia, insulin resistance and hypertension. Clinical evidence indicated the coexistence of metabolic syndrome and depression. However, relatively few studies have been attempted to determine the pathogenesis of metabolic syndrome-associated anxiety. In the present study, the role of metabolic syndrome in the development of anxiety and the role of neurotransmitters in metabolic syndrome-associated anxiety were evaluated in Swiss albino mice. A high-fat and high-carbohydrate diet was used to develop the metabolic syndrome in mice while monitoring elevated fasting blood glucose, hyperlipidaemia and hypertension. Anxiety levels were measured using elevated plus maze and marble burying test with corresponding determination of serum corticosterone levels. The role of.-aminobutyric acid and serotonin in metabolic syndrome-associated anxiety were also evaluated. The high-fat and high-carbohydrate fed animals developed metabolic syndrome, characterized by significant high fasting blood glucose and insulin resistance compared to controls. These animals also had significant increase in body weight and waist circumference, low-density lipoprotein and triglyceride levels, reduced high-density lipoprotein content and high blood pressure. Both metabolic syndrome and water avoidance-anxiety groups spent significantly lower time and showed fewer entries into the open arm of elevated plus maze. They also buried more marbles, thus showing clear signs of anxiety when compared to controls. The corticosterone level in metabolic syndrome and anxiety-induced animals were higher than controls. GABA agonists showed a dose-dependent reduction in metabolic syndrome-associated anxiety as revealed by more time spent on the open arm of plus maze with a corresponding decrease in plasma corticosterone levels. Metabolic syndrome animals spontaneously developed anxiety-like behaviour. GABA agonists partially reversed the metabolic syndrome-associated anxiety, suggesting a role for GABAergic pathway.
C1 [Mukherjee, A.] Gupta Coll Technol Sci, Dept Pharmacol, Asansol 713301, India.
   [Banerjee, S.] Birla Inst Technol, Dept Pharmaceut Sci & Technol, Ranchi 835215, Bihar, India.
C3 Birla Institute of Technology Mesra
RP Banerjee, S (corresponding author), Birla Inst Technol, Dept Pharmaceut Sci & Technol, Ranchi 835215, Bihar, India.
EM sbanerjee@bitmesra.ac.in
RI Mukherjee, Aniruddha/S-7889-2019; BANERJEE, SUGATO/L-9012-2019;
   BANERJEE, SUGATO/M-7317-2017
OI Mukherjee, Aniruddha/0009-0005-8397-6061; BANERJEE,
   SUGATO/0000-0002-4402-3066
FU Department of Pharmaceutical Sciences and Technology, BIT, Mesra
FX Authors express their gratitude to Prof Late Debesh Chandra Majumdar,
   Chairman, Trinity trust, Dr. Kalyan K. Sen, principal and all the
   faculty members of Gupta College of Technological Sciences Asansol, for
   their constant support and encouragement. Authors also thank the
   Department of Pharmaceutical Sciences and Technology, BIT, Mesra for its
   support.
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NR 43
TC 0
Z9 1
U1 0
U2 5
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, 400059, INDIA
SN 0250-474X
EI 1998-3743
J9 INDIAN J PHARM SCI
JI Indian J. Pharm. Sci.
PD MAY-JUN
PY 2018
VL 80
IS 3
BP 453
EP 459
DI 10.4172/pharmaceutical-sciences.1000378
PG 7
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA GP0PG
UT WOS:000440512000007
OA gold
DA 2025-06-11
ER

PT J
AU Jorgensen, A
AF Jorgensen, Anders
TI Oxidatively generated DNA/RNA damage in psychological stress states
SO DANISH MEDICAL JOURNAL
LA English
DT Article
ID MAJOR DEPRESSIVE DISORDER; BASE EXCISION-REPAIR; DNA-DAMAGE; PERCEIVED
   STRESS; LIPID-PEROXIDATION; MITOCHONDRIAL DYSFUNCTION; METABOLIC
   SYNDROME; NUCLEAR-DNA; LIFE-SPAN; SCHIZOPHRENIA
AB `
C1 [Jorgensen, Anders] Rigshosp, Dept O, Psychiat Ctr Copenhagen, DK-2100 Copenhagen O, Denmark.
C3 Rigshospitalet
RP Jorgensen, A (corresponding author), Rigshosp, Dept O, Psychiat Ctr Copenhagen, Blegdamsvej 9, DK-2100 Copenhagen O, Denmark.
EM aj@dadlnet.dk
RI Jorgensen, Anders/H-6325-2018
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NR 140
TC 9
Z9 9
U1 0
U2 5
PU DANISH MEDICAL ASSOC
PI COPENHAGEN
PA TRONDHJEMSGADE 9, DK-2100 COPENHAGEN, DENMARK
EI 2245-1919
J9 DAN MED J
JI Dan. Med. J.
PD JUL
PY 2013
VL 60
IS 7
AR B4685
PG 14
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA AP4IS
UT WOS:000342041000018
PM 23809980
DA 2025-06-11
ER

PT J
AU Hiles, SA
   Révész, D
   Lamers, F
   Giltay, E
   Penninx, BWJH
AF Hiles, Sarah A.
   Revesz, Dora
   Lamers, Femke
   Giltay, Erik
   Penninx, Brenda W. J. H.
TI BIDIRECTIONAL PROSPECTIVE ASSOCIATIONS OF METABOLIC SYNDROME COMPONENTS
   WITH DEPRESSION, ANXIETY, AND ANTIDEPRESSANT USE
SO DEPRESSION AND ANXIETY
LA English
DT Article
DE depression; anxiety; antidepressive agents; metabolic syndrome; obesity;
   dyslipidemia; longitudinal studies; comorbidity
ID LIFE-STYLE FACTORS; OF-THE-LITERATURE; BLOOD-PRESSURE; MAJOR DEPRESSION;
   PSYCHOMETRIC PROPERTIES; SYMPTOMATOLOGY IDS; PHYSICAL-ACTIVITY;
   METAANALYSIS; RISK; CHOLESTEROL
AB Background: Metabolic syndrome components-waist circumference, high-density lipoprotein cholesterol (HDL-C), triglycerides, systolic blood pressure and fasting glucose-are cross-sectionally associated with depression and anxiety with differing strength. Few studies examine the relationships over time or whether antidepressants have independent effects. Methods: Participants were from the Netherlands Study of Depression and Anxiety (NESDA; N = 2,776; 18-65 years; 66% female). At baseline, 2- and 6-year follow-up, participants completed diagnostic interviews, depression and anxiety symptom inventories, antidepressant use assessment, and measurements of the five metabolic syndrome components. Data were analyzed for the consistency of associations between psychopathology indicators and metabolic syndrome components across the three assessment waves, and whether psychopathology or antidepressant use at one assessment predicts metabolic dysregulation at the next and vice versa. Results: Consistently across waves, psychopathology was associated with generally poorer values of metabolic syndrome components, particularly waist circumference and triglycerides. Stronger associations were observed for psychopathology symptom severity than diagnosis. Antidepressant use was independently associated with higher waist circumference, triglycerides and number of metabolic syndrome abnormalities, and lower HDL-C. Symptom severity and antidepressant use were associated with subsequently increased number of abnormalities, waist circumference, and glucose after 2 but not 4 years. Conversely, there was little evidence that metabolic syndrome components were associated with subsequent psychopathology outcomes. Conclusions: Symptom severity and antidepressant use were independently associated with metabolic dysregulation consistently over time and also had negative consequences for short-term metabolic health. This is of concern given the chronicity of depression and anxiety and prevalence of antidepressant treatment. (C) 2016 The Authors. Depression and Anxiety published by Wiley Periodicals, Inc.
C1 [Hiles, Sarah A.; Revesz, Dora; Lamers, Femke; Penninx, Brenda W. J. H.] Vrije Univ Amsterdam, Med Ctr, Dept Psychiat, AJ Ernststr 1187, NL-1081 HL Amsterdam, Netherlands.
   [Hiles, Sarah A.; Revesz, Dora; Lamers, Femke; Penninx, Brenda W. J. H.] Vrije Univ Amsterdam, Med Ctr, EMGO Inst Hlth & Care Res, Amsterdam, Netherlands.
   [Giltay, Erik] Leiden Univ, Med Ctr, Dept Psychiat, Leiden, Netherlands.
C3 Vrije Universiteit Amsterdam; Vrije Universiteit Amsterdam; Leiden
   University; Leiden University Medical Center (LUMC); Leiden University -
   Excl LUMC
RP Hiles, SA (corresponding author), Vrije Univ Amsterdam, Med Ctr, Dept Psychiat, AJ Ernststr 1187, NL-1081 HL Amsterdam, Netherlands.
EM s.hiles@vumc.nl
RI Lamers, Femke/G-5161-2012; Giltay, Erik/AAL-9948-2021; Hiles,
   Sarah/AAE-3430-2019; Penninx, Brenda/S-7627-2017
OI Hiles, Sarah/0000-0002-2723-2798; Lamers, Femke/0000-0003-4344-5766;
   Giltay, Erik J./0000-0001-8874-2292
FU Netherlands Organisation for Health Research and Development
   [10-000-1002]; European Union [658897, PCIG12-GA-2012-334065]; NWO-VICI
   [91811602]; Marie Curie Actions (MSCA) [658897] Funding Source: Marie
   Curie Actions (MSCA)
FX Contract grant sponsor: The Netherlands Organisation for Health Research
   and Development; Contract grant number: 10-000-1002; Contract grant
   sponsor: European Union Horizon 2020 Marie Sklodowska-Curie Programme;
   Contract grant number: 658897; Contract grant sponsor: European Union
   Seventh Framework Programme (FP7/2007-2013); Contract grant number:
   PCIG12-GA-2012-334065; Contract grant sponsor: NWO-VICI; Contract grant
   number: 91811602.
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NR 64
TC 77
Z9 81
U1 1
U2 10
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1091-4269
EI 1520-6394
J9 DEPRESS ANXIETY
JI Depress. Anxiety
PD AUG
PY 2016
VL 33
IS 8
BP 754
EP 764
DI 10.1002/da.22512
PG 11
WC Psychology, Clinical; Psychiatry; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA DW5TH
UT WOS:000383709300010
PM 27120696
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Guo, Y
   Luo, SY
   Ye, YX
   Yin, SP
   Fan, JH
   Xia, M
AF Guo, Yi
   Luo, Shiyun
   Ye, Yongxin
   Yin, Songping
   Fan, Jiahua
   Xia, Min
TI Intermittent Fasting Improves Cardiometabolic Risk Factors and Alters
   Gut Microbiota in Metabolic Syndrome Patients
SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Article
DE intermittent fasting; cardiometabolic risk factors; gut microbiota;
   metabolic syndrome
ID CONTINUOUS ENERGY RESTRICTION; WEIGHT-LOSS; CARDIOVASCULAR-DISEASE;
   CALORIC RESTRICTION; MORTALITY; MARKERS; HEALTH; AUTOIMMUNITY;
   PREVENTION; REDUCTION
AB Context: Intermittent fasting (IF) is an effective strategy to improve cardiometabolic health.
   Objective: The objective of this work is to examine the effects of IF on cardiometabolic risk factors and the gut microbiota in patients with metabolic syndrome (MS).
   Design and setting: A randomized clinical trial was conducted at a community health service center.
   Patients: Participants included adults with MS, age 30 to 50 years.
   Intervention: Intervention consisted of 8 weeks of "2-day" modified IF.
   Main outcome measure: Cardiometabolic risk factors including body composition, oxidative stress, inflammatory cytokines, and endothelial function were assessed at baseline and at 8 weeks. The diversity, composition, and functional pathways of the gut microbiota, as well as circulating gut-derived metabolites, were measured.
   Results: Thirty-nine patients with MS were included: 21 in the IF group and 18 in the control group. On fasting days, participants in the IF group reduced 69% of their calorie intake compared to nonfasting days. The 8-week IF significantly reduced fat mass, ameliorated oxidative stress, modulated inflammatory cytokines, and improved vasodilatory parameters. Furthermore, IF induced significant changes in gut microbiota communities, increased the production of short-chain fatty acids, and decreased the circulating levels of lipopolysaccharides. The gut microbiota alteration attributed to the IF was significantly associated with cardiovascular risk factors and resulted in distinct genetic shifts of carbohydrate metabolism in the gut community.
   Conclusion: IF induces a significant alteration of the gut microbial community and functional pathways in a manner closely associated with the mitigation of cardiometabolic risk factors. The study provides potential mechanistic insights into the prevention of adverse outcomes associated with MS.
C1 [Guo, Yi; Luo, Shiyun; Ye, Yongxin; Yin, Songping; Fan, Jiahua; Xia, Min] Sun Yat Sen Univ, Guangdong Prov Key Lab Food Nutr & Hlth, Sch Publ Hlth, Northern Campus, Guangzhou 510080, Guangdong, Peoples R China.
   [Guo, Yi; Luo, Shiyun; Ye, Yongxin; Yin, Songping; Fan, Jiahua; Xia, Min] Sun Yat Sen Univ, Dept Nutr, Sch Publ Hlth, Northern Campus, Guangzhou 510080, Guangdong, Peoples R China.
C3 Sun Yat Sen University; Sun Yat Sen University
RP Xia, M (corresponding author), Sun Yat Sen Univ, Dept Nutr, Sch Publ Hlth, 74,2nd Zhongshan Rd, Guangzhou 510080, Peoples R China.
EM xiamin@mail.sysu.edu.cn
OI Ye, Yongxin/0000-0002-4982-0814
FU National Key Research and Development Program of China [2017YFC0907100,
   2017YFC0907101]; Natural Science Foundation of China-Guangdong Joint
   Fund [U1801281]; Science and Technology Innovation Talents
FX This work was supported by the National Key Research and Development
   Program of China (No. 2017YFC0907100 and 2017YFC0907101), the Natural
   Science Foundation of China-Guangdong Joint Fund (No. U1801281), and
   Science and Technology Innovation Talents.
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NR 49
TC 124
Z9 131
U1 3
U2 54
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0021-972X
EI 1945-7197
J9 J CLIN ENDOCR METAB
JI J. Clin. Endocrinol. Metab.
PD JAN
PY 2021
VL 106
IS 1
BP 64
EP 79
PG 16
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA PT2WX
UT WOS:000608480200059
PM 33017844
OA Bronze
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Gebreab, SZ
   Vandeleur, CL
   Rudaz, D
   Strippoli, MPF
   Gholam-Rezaee, M
   Castelao, E
   Lasserre, AM
   Glaus, J
   Pistis, G
   Kuehner, C
   von Känel, R
   Marques-Vidal, P
   Vollenweider, P
   Preisig, M
AF Gebreab, Sirak Zenebe
   Vandeleur, Caroline L.
   Rudaz, Dominique
   Strippoli, Marie-Pierre F.
   Gholam-Rezaee, Mehdi
   Castelao, Enrique
   Lasserre, Aurelie M.
   Glaus, Jennifer
   Pistis, Giorgio
   Kuehner, Christine
   von Kanel, Roland
   Marques-Vidal, Pedro
   Vollenweider, Peter
   Preisig, Martin
TI Psychosocial Stress Over the Lifespan, Psychological Factors, and
   Cardiometabolic Risk in the Community
SO PSYCHOSOMATIC MEDICINE
LA English
DT Article
DE cardiometabolic risk; childhood adversity; life events; major depressive
   disorder; personality; psychosocial stress
ID ADVERSE CHILDHOOD EXPERIENCES; BODY-MASS INDEX; DIAGNOSTIC INTERVIEW;
   CARDIOVASCULAR RISK; METABOLIC SYNDROME; WAIST CIRCUMFERENCE; HEALTH;
   DEPRESSION; OBESITY; DISORDER
AB Objective The complex relationship between psychosocial stress over the lifetime, psychological factors, and cardiometabolic risk is still poorly understood. Accordingly, our aims were (1) to independently assess the associations between childhood adversity, life-event stress in remote (earlier than the last 5 years), and recent adulthood and cardiometabolic risk, and (2) to determine the role of psychological factors including personality, coping, and depression in these associations.
   Methods The sample included 2674 adults, aged 35 to 66 years, randomly selected from urban area. Participants underwent a physical examination including the assessment of obesity markers, blood pressure, and blood lipid and glucose levels. Stress during adulthood was determined using the severity scores of 52 stressful life events. Information on adverse childhood experiences and major depressive disorders was collected using semistructured interviews, whereas personality traits and coping mechanisms were evaluated through questionnaires.
   Results Both childhood adversity and stress in remote adulthood were associated with elevated body mass index ( [95% confidence interval {CI}] = 0.249 [0.029 to 0.468]; 0.020 [0.006 to 0.034]), waist circumference ( [95% CI] = 0.061 [0.024 to 0.099]; 0.08 [0.04 to 0.11]), and the global cardiometabolic risk score ( [95% CI] = 0.278 [0.017 to 0.540]; 0.017 [0.001 to 0.033]) after adjustment for sociodemographic, lifestyle, and psychological factors. In addition, childhood adversity was associated with low high density lipoprotein levels ( [95% CI] = -0.021 [-0.042 to 0.000]), as well as increased fat mass and systolic blood pressure levels ( [95% CI] = 0.506 [0.165 to 0.846]; 0.952 [0.165 to 1.740]) and stress in remote adulthood with apolipoprotein B levels ( [95% CI] = 0.607 [0.312 to 0.901]). Psychological factors did not account for these associations and were not effect modifiers.
   Conclusions Our data demonstrate that psychosocial stress during childhood and remote adulthood favor adiposity and abnormal lipid metabolism.
C1 [Gebreab, Sirak Zenebe; Vandeleur, Caroline L.; Rudaz, Dominique; Strippoli, Marie-Pierre F.; Gholam-Rezaee, Mehdi; Castelao, Enrique; Lasserre, Aurelie M.; Glaus, Jennifer; Pistis, Giorgio; Preisig, Martin] Lausanne Univ Hosp, Ctr Psychiat Epidemiol & Psychopathol, Dept Psychiat, Site Cery,1008 Prilly, Lausanne, Switzerland.
   [Marques-Vidal, Pedro; Vollenweider, Peter] Lausanne Univ Hosp, Dept Med, Internal Med, Lausanne, Switzerland.
   [Glaus, Jennifer] NIMH, Genet Epidemiol Res Branch, Intramural Res Program, Bethesda, MD 20892 USA.
   [Kuehner, Christine] Heidelberg Univ, Cent Inst Mental Hlth, Med Fac Mannheim, Longitudinal & Intervent Res, Mannheim, Germany.
   [von Kanel, Roland] Zurich Univ Hosp, Dept Consultat Liaison Psychiat & Psychosomat Med, Zurich, Switzerland.
C3 University of Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV);
   National Institutes of Health (NIH) - USA; NIH National Institute of
   Mental Health (NIMH); Central Institute of Mental Health; Ruprecht Karls
   University Heidelberg; University of Zurich; University Zurich Hospital
RP Gebreab, SZ (corresponding author), Lausanne Univ Hosp, Ctr Psychiat Epidemiol & Psychopathol, Dept Psychiat, Site Cery,1008 Prilly, Lausanne, Switzerland.
EM sirak.gebreab@chuv.ch
RI Preisig, Martin/H-3441-2016; Glaus, Jennifer/C-7887-2017; Lasserre,
   Aurelie M/AEA-0456-2022; von Kanel, Roland/B-1811-2019; Marques-Vidal,
   Pedro/C-9449-2009; Vollenweider, Peter/Q-4603-2016
OI Strippoli, Marie-Pierre/0000-0003-3053-484X; Lasserre, Aurelie
   M/0000-0003-3925-6663; Vandeleur, Caroline/0000-0001-9092-6648; Preisig,
   Martin/0000-0001-5689-4259; von Kanel, Roland/0000-0002-8929-5129;
   Marques-Vidal, Pedro/0000-0002-4548-8500; Glaus,
   Jennifer/0000-0001-8883-9473; Castelao, Enrique/0000-0003-1966-3683;
   GEBREAB, SIRAK ZENEBE/0000-0001-5849-075X; Vollenweider,
   Peter/0000-0002-0765-896X
FU GlaxoSmithKline; Faculty of Biology and Medicine of Lausanne; Swiss
   National Science Foundation [3200B0-105993, 3200B0-118308,
   33CSCO-122661, 33CS30-139468, 33CS30-148401]
FX This research was and is supported by research grants from
   GlaxoSmithKline, the Faculty of Biology and Medicine of Lausanne, and
   the Swiss National Science Foundation (Grants 3200B0-105993,
   3200B0-118308, 33CSCO-122661, 33CS30-139468, and 33CS30-148401). The
   authors report no conflicts of interest.
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NR 70
TC 27
Z9 28
U1 1
U2 17
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0033-3174
EI 1534-7796
J9 PSYCHOSOM MED
JI Psychosom. Med.
PD SEP
PY 2018
VL 80
IS 7
BP 628
EP 639
DI 10.1097/PSY.0000000000000621
PG 12
WC Psychiatry; Psychology; Psychology, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry; Psychology
GA GS8IY
UT WOS:000443954400005
PM 29965943
OA Green Published, Green Accepted
DA 2025-06-11
ER

PT J
AU Mehrabi, F
   Amiri, P
   Cheraghi, L
   Kheradmand, A
   Hosseinpanah, F
   Azizi, F
AF Mehrabi, Fahimeh
   Amiri, Parisa
   Cheraghi, Leila
   Kheradmand, Ali
   Hosseinpanah, Farhad
   Azizi, Fereidoun
TI Emotional states of different obesity phenotypes: a sex-specific study
   in a west-Asian population
SO BMC PSYCHIATRY
LA English
DT Article
DE Metabolic syndrome; Obesity; Depression; Anxiety; Stress; Metabolically
   healthy obesity
ID METABOLIC SYNDROME; DEPRESSIVE SYMPTOMS; GENDER-DIFFERENCES; DISORDERS;
   ANXIETY; ASSOCIATION; GLUCOSE; HEALTHY; COMMON; WOMEN
AB BackgroundThe present study aimed to investigate the associations of obesity phenotypes with depression, anxiety, and stress symptoms among adults in the Tehran Lipid and Glucose Study (TLGS).MethodsDepression, anxiety, and stress levels of participants from the TLGS were examined among different obesity phenotypes in this cross-sectional study.Obesity was defined as body mass index (BMI) >= 30kg/m(2), and metabolically unhealthy status based on having metabolic syndrome (MetS) or type 2 diabetes. Four obesity phenotypes were defined: 1) Metabolically Healthy Non-Obese (MHNO), 2) Metabolically Healthy Obese (MHO) 3) Metabolically Unhealthy Non-Obese (MUNO), and 4) Metabolically Unhealthy Obese (MUO). Emotional states of different obesity phenotypes were assessed by the Persian version of depression, anxiety, and stress scale-21 items (DASS-21). Ordinal logistic regression analysis was used to compare sex-specific odds ratios of depression, anxiety, and stress in different obesity phenotypes.ResultsThe mean age of 2469 men and women was 46.215.9 and 45.6 +/- 14.7, respectively. In total, women were more likely to experience higher levels of depression (30.5%), anxiety (44.2%), and stress (43.5%) symptoms compared to men. After adjusting for potential confounders, compared to MHNO men, the odds of experiencing higher anxiety levels were significantly greater in metabolically unhealthy men whether they were obese (OR: 1.78, 95% CI: 1.25-2.54; P =<0.001) or non-obese (OR: 1.61, 95% CI: 1.17-2.21; P =<0.001), and also in MUO women (OR: 1.73, 95% CI: 1.28-2.34; P =<0.001) compared to MHNO women. Moreover, the odds of experiencing higher stress levels were significantly greater in MUNO men (OR: 1.40, 95% CI: 1.02-1.90; P =0.04) compared to MHNO men and in MUO women (OR: 1.45, 95% CI: 1.07-1.96; P =0.02) compared to MHNO women. No difference in depression levels was observed in either sex.Conclusions Our results showed that men and women with various obesity phenotypes experienced different anxiety and stress levels. While MUO women and all metabolically unhealthy men experienced more anxiety and stress levels than MHNO individuals, none of the obesity phenotypes were associated with depression. These findings provide insight into recognizing the psychological consequences of different phenotypes of obesity in both sexes and utilizing future health promotion planning.
C1 [Mehrabi, Fahimeh; Amiri, Parisa; Cheraghi, Leila] Shahid Beheshti Univ Med Sci, Res Inst Endocrine Sci, Res Ctr Social Determinants Hlth, POB 19395-4763, Tehran, Iran.
   [Cheraghi, Leila] Shahid Beheshti Univ Med Sci, Res Inst Endocrine Sci, Dept Epidemiol & Biostat, Tehran, Iran.
   [Kheradmand, Ali] Shahid Beheshti Univ Med Sci, Taleghani Hosp Res Dev Comm, Dept Psychiat, Tehran, Iran.
   [Hosseinpanah, Farhad] Shahid Beheshti Univ Med Sci, Res Inst Endocrine Sci, Obes Res Ctr, Tehran, Iran.
   [Amiri, Parisa; Azizi, Fereidoun] Shahid Beheshti Univ Med Sci, Res Inst Endocrine Sci, Endocrine Res Ctr, Tehran, Iran.
C3 Shahid Beheshti University Medical Sciences; Shahid Beheshti University
   Medical Sciences; Shahid Beheshti University Medical Sciences; Shahid
   Beheshti University Medical Sciences; Shahid Beheshti University Medical
   Sciences
RP Amiri, P (corresponding author), Shahid Beheshti Univ Med Sci, Res Inst Endocrine Sci, Endocrine Res Ctr, Tehran, Iran.
EM amiri@endocrine.ac.ir
RI kheradmand, ali/AAR-7441-2021; hosseinpanah, farhad/AAM-7277-2020;
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   Fereidoun/ABD-4136-2021
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   Azizi, Fereidoun/0000-0002-6470-2517; Mehrabi,
   Fahimeh/0000-0001-9715-6543
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NR 51
TC 9
Z9 9
U1 0
U2 6
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-244X
J9 BMC PSYCHIATRY
JI BMC Psychiatry
PD MAR 4
PY 2021
VL 21
IS 1
AR 124
DI 10.1186/s12888-021-03131-3
PG 10
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA QT3ZT
UT WOS:000626529100004
PM 33663426
OA gold, Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Berto, LF
   Suemoto, CK
   Moreno, AB
   Fonseca, MDM
   Nunes, MAA
   Molina, MDB
   Barreto, SM
   Diniz, MDHS
   Lotufo, PA
   Bensenor, IM
   Brunoni, AR
AF Berto, Laura F.
   Suemoto, Claudia K.
   Moreno, Arlinda B.
   Fonseca, Maria de Jesus M.
   Nunes, Maria Angelica A.
   Molina, Maria del Carmen B.
   Barreto, Sandhi M.
   Diniz, Maria de Fatima Haueisen Sander
   Lotufo, Paulo A.
   Bensenor, Isabela M.
   Brunoni, Andre R.
TI Increased Prevalence of Depression and Anxiety Among Subjects With
   Metabolic Syndrome in the Brazilian Longitudinal Study of Adult Health
   (ELSA-Brasil)
SO JOURNAL OF THE ACADEMY OF CONSULTATION-LIAISON PSYCHIATRY
LA English
DT Article
DE depression; anxiety; common mental dis-orders; metabolic syndrome
ID ASSOCIATION; DISORDER; RISK; QUESTIONNAIRE; HYPERTENSION; METAANALYSIS;
   MORBIDITY; INTERVIEW; SYMPTOMS; VALIDITY
AB Background: Metabolic syndrome (MetS) and common mental disorders are prevalent conditions. However, the relationship of MetS and its components with depression, anxiety, and common mental disorders has not been suf-ficiently addressed in low-/middle-income countries. Objective: To investigate whether depression, anxiety, and common mental disorders are associated with MetS and its components in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). Methods: A cross-sectional analysis of the ELSA-Brasil baseline visit (2008-2010) was performed. Adults without cardiovascular diseases had their MetS status defined by the National Cholesterol Ed-ucation Program's Adult Treatment Panel III criteria. We assessed mental disorders using the Clinical Interview Schedule-Revised. We employed multiple logistic regres-sion models adjusted for sociodemographic and behavioral factors. The dependent variables were mental disorders, and the independent variables were MetS and its components. We also performed analyses stratified by age and gender. Results: Our sample included 12,725 participants (54.9% women, mean age of 51.8 +/- 8.9 y). MetS and depressive disorders were significantly associated (odds ratio [OR] = 1.55, 95% confidence interval [CI] 1.30-1.85). Increased abdominal circumference (OR = 1.54, 95% CI 1.29-1.84), diabetes mellitus (OR = 1.24, 95% CI 1.02-1.50), hypertriglyceridemia (OR = 1.33, 95% CI 1.11-1.60), and low high-density lipoprotein cholesterol (only when adjusted for sociodemographic factors) (OR = 1.25, 95% CI 1.02-1.52) were also associated with depression. This association remained significant for all stratified analyses. Finally, MetS was also significantly associated with anxiety disorders (OR = 1.19, 95% CI 1.07-1.32) and common mental disorders (OR = 1.27, 95% CI 1.17-1.39). Conclusions: Our cross-sectional findings suggested that depression, anxiety, and common mental disorder are associated with MetS. Depression was also associated with abdominal obesity, elevated blood glucose, elevated triglycerides, and reduced high-density lipoprotein cholesterol, but not with hypertension. (Journal of the Academy of Consultation-Liaison Psy-chiatry 2022; 63:529-538)
C1 [Berto, Laura F.; Suemoto, Claudia K.; Lotufo, Paulo A.; Bensenor, Isabela M.; Brunoni, Andre R.] Univ Sao Paulo, Fac Med, Sao Paulo, SP, Brazil.
   [Suemoto, Claudia K.; Lotufo, Paulo A.; Bensenor, Isabela M.; Brunoni, Andre R.] Hosp Univ, Univ Sao Paulo, Ctr Clin & Epidemiol Res, Sao Paulo, SP, Brazil.
   [Moreno, Arlinda B.; Fonseca, Maria de Jesus M.] Fundacao Oswaldo Cruz, Natl Sch Publ Hlth, Dept Epidemiol & Quantitat Methods Hlth, Rio De Janeiro, RJ, Brazil.
   [Nunes, Maria Angelica A.; Diniz, Maria de Fatima Haueisen Sander] Univ Fed Rio Grande, Postgrad Program Epidemiol, Porto Alegre, Rio Grande do S, Brazil.
   [Molina, Maria del Carmen B.] Univ Fed Espirito Santo, Postgrad Program Publ Hlth, Vitoria, ES, Brazil.
   [Barreto, Sandhi M.] Fac Med Univ Fed Minas Gerais, Dept Prevent & Social Med, Belo Horizonte, MG, Brazil.
   [Diniz, Maria de Fatima Haueisen Sander] Univ Fed Minas Gerais, Hosp Clin, Fac Med, Belo Horizonte, MG, Brazil.
   [Lotufo, Paulo A.; Bensenor, Isabela M.; Brunoni, Andre R.] Fac Med Univ Sao Paulo, Dept Internal Med, Sao Paulo, SP, Brazil.
   [Berto, Laura F.] Psychiat Inst Washington DC, Serv Interdisciplinary Neuromodulat, Dr Ovidio Pires Campos St 785,2nd Store Ala, BR-05403000 Sao Paulo, Brazil.
C3 Universidade de Sao Paulo; Universidade de Sao Paulo; Fundacao Oswaldo
   Cruz; Universidade Federal do Rio Grande; Universidade Federal do
   Espirito Santo; Universidade Federal de Minas Gerais; Universidade de
   Sao Paulo
RP Berto, LF (corresponding author), Psychiat Inst Washington DC, Serv Interdisciplinary Neuromodulat, Dr Ovidio Pires Campos St 785,2nd Store Ala, BR-05403000 Sao Paulo, Brazil.
EM laura.berto@fm.usp.br
RI Fonseca, Maria/HTR-3788-2023; Moreno, Arlinda/H-3975-2013; Lotufo,
   Paulo/A-9843-2008; Bensenor, Isabela/L-3306-2017; Fernandes Berto,
   Laura/KDO-3266-2024; Barreto, Sandhi/D-2855-2014; Suemoto,
   Claudia/C-7218-2012; Russowsky Brunoni, Andre/H-8394-2012
OI Bensenor, Isabela/0000-0002-6723-5678; Suemoto,
   Claudia/0000-0002-5942-4778; Fernandes Berto, Laura/0000-0003-2318-559X;
   Russowsky Brunoni, Andre/0000-0002-6310-3571; Barbosa Moreno,
   Arlinda/0000-0002-8282-6521
FU Brazilian Ministry of Health [01060010.00RS, 01060212.00BA,
   01060300.00ES, 01060278.00MG, 01060115.00SP, 01060071.00RJ]; Sao Paulo
   Research State Foundation [2018/10861-7, 2019/06009-6]; Brazilian
   National Council of Scientific Development [PQ-1B]; University of Sao
   Paulo Medical School; Selo Paulo Research State Foundation (FAPESP)
   [2020/06887-0]
FX The ELSA-Brasil study was supported by the Brazilian Ministry of Health
   (grants 01060010.00RS, 01060212.00BA, 01060300.00ES, 01060278.00MG,
   01060115.00SP, 01060071.00RJ) . A.R.B. reports grants from Sao Paulo
   Research State Foundation (2018/10861-7, 2019/06009-6) , Brazilian
   National Council of Scienti fi c Development productivity support
   (PQ-1B) , and University of Sao Paulo Medical School productivity
   support (PIPA-A) . L.F.B. receives a Scienti fi c Initiation grant from
   Selo Paulo Research State Foundation (FAPESP 2020/06887-0) .
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NR 59
TC 4
Z9 4
U1 3
U2 8
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 2667-2960
J9 J ACAD CONSULT-LIAIS
JI J. Acad. Consult.-Liaison Psychiat.
PD NOV-DEC
PY 2022
VL 63
IS 6
BP 529
EP 538
DI 10.1016/j.jaclp.2022.06.001
EA DEC 2022
PG 10
WC Psychiatry; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry; Psychology
GA 7V4ZK
UT WOS:000912823500001
PM 35718085
DA 2025-06-11
ER

PT J
AU Kim, HG
   Cheon, EJ
   Bai, DS
   Lee, YH
   Koo, BH
AF Kim, Hye-Geum
   Cheon, Eun-Jin
   Bai, Dai-Seg
   Lee, Young Hwan
   Koo, Bon-Hoon
TI Stress and Heart Rate Variability: A Meta-Analysis and Review of the
   Literature
SO PSYCHIATRY INVESTIGATION
LA English
DT Review
DE Heart rate variability; Stress; Autonomic nervous system
ID MEDIAL PREFRONTAL CORTEX; MENTAL STRESS; BAROREFLEX SENSITIVITY;
   PSYCHOLOGICAL STRESS; METABOLIC-SYNDROME; CONDITIONED FEAR;
   BLOOD-PRESSURE; WORK STRESS; JOB STRESS; RISK
AB Objective Physical or mental imbalance caused by harmful stimuli can induce stress to maintain homeostasis. During chronic stress, the sympathetic nervous system is hyperactivated, causing physical, psychological, and behavioral abnormalities. At present, there is no accepted standard for stress evaluation. This review aimed to survey studies providing a rationale for selecting heart rate variability (HRV) as a psychological stress indicator.
   Methods Term searches in the Web of Science (R), National Library of Medicine (PubMed), and Google Scholar databases yielded 37 publications meeting our criteria. The inclusion criteria were involvement of human participants, HRV as an objective psychological stress measure, and measured HRV reactivity.
   Results In most studies, HRV variables changed in response to stress induced by various methods. The most frequently reported factor associated with variation in HRV variables was low parasympathetic activity, which is characterized by a decrease in the high-frequency band and an increase in the low-frequency band. Neuroimaging studies suggested that HRV may be linked to cortical regions (e.g., the ventromedial prefrontal cortex) that are involved in stressful situation appraisal.
   Conclusion In conclusion, the current neurobiological evidence suggests that HRV is impacted by stress and supports its use for the objective assessment of psychological health and stress.
C1 [Kim, Hye-Geum; Koo, Bon-Hoon] Yeungnam Univ, Coll Med, Dept Psychiat, 170 Hyeonchung Ro, Daegu 42415, South Korea.
   [Cheon, Eun-Jin; Lee, Young Hwan] Yeungnam Univ, Coll Med, Dept Pediat, 170 Hyeonchung Ro, Daegu 42415, South Korea.
   [Bai, Dai-Seg] Yeungnam Univ, Med Ctr, Dept Psychiat, Div Clin Psychol, Daegu, South Korea.
C3 Yeungnam University; Yeungnam University; Yeungnam University
RP Koo, BH (corresponding author), Yeungnam Univ, Coll Med, Dept Psychiat, 170 Hyeonchung Ro, Daegu 42415, South Korea.; Lee, YH (corresponding author), Yeungnam Univ, Coll Med, Dept Pediat, 170 Hyeonchung Ro, Daegu 42415, South Korea.
EM yhlee3535@ynu.ac.kr; vijnana@chol.com
RI Koo, Bon Hoon/KOD-4275-2024
OI Koo, Bon Hoon/0000-0001-9633-3835
FU National Research Foundation of Korea (NRF) grant - Korean government
   (MSIP: Ministry of Science, ICT, and Future Planning) [216C000671]
FX This work was supported by the National Research Foundation of Korea
   (NRF) grant funded by the Korean government (MSIP: Ministry of Science,
   ICT, and Future Planning) (No. 216C000671).
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NR 76
TC 1275
Z9 1412
U1 30
U2 326
PU KOREAN NEUROPSYCHIATRIC ASSOC
PI SEOUL
PA RN 522, G-FIVE CENTRAL PLAZA 1685-8 SEOCHO 4-DONG, SEOCHO-GU, SEOUL,
   137-882, SOUTH KOREA
SN 1738-3684
EI 1976-3026
J9 PSYCHIAT INVEST
JI Psychiatry Investig.
PD MAR
PY 2018
VL 15
IS 3
BP 235
EP 245
DI 10.30773/pi.2017.08.17
PG 11
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA FZ6BQ
UT WOS:000427682300003
PM 29486547
OA Green Published, Green Submitted, gold
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Sadeghi, O
   Keshteli, AH
   Afshar, H
   Esmaillzadeh, A
   Adibi, P
AF Sadeghi, Omid
   Keshteli, Ammar Hassanzadeh
   Afshar, Hamid
   Esmaillzadeh, Ahmad
   Adibi, Peyman
TI Adherence to Mediterranean dietary pattern is inversely associated with
   depression, anxiety and psychological distress
SO NUTRITIONAL NEUROSCIENCE
LA English
DT Article
DE Anxiety; depression; diet; Mediterranean; psychological distress
ID COMMUNITY-DWELLING ADULTS; METABOLIC SYNDROME; MAGNESIUM
   SUPPLEMENTATION; MENTAL-DISORDERS; IRANIAN ADULTS; SYMPTOMS; HEALTH;
   PREVALENCE; PERIMENOPAUSAL; ABNORMALITIES
AB Background Few studies have assessed adherence to the Mediterranean diet in relation to psychological health, in particular in the Middle East. Objective To examine the association between adherence to Mediterranean dietary pattern and prevalence of psychological disorders among a large population of Iranian adults. Design In this cross-sectional study on 3172 Iranian adults aged 18-55 years, we used a validated food frequency questionnaire for the assessment of dietary intakes. Adherence to the Mediterranean dietary pattern was examined using the Trichopoulou et al. method. To assess psychological health, the Iranian validated version of the Hospital Anxiety and Depression Scale (HADS) was used. Psychological distress was assessed through the use of General Health Questionnaire (GHQ). Results Mean age of study participants was 36.54 +/- 4.97 years. After controlling for potential confounders, participants with the greatest adherence to the Mediterranean diet had lower odds for depression (OR: 0.60, 95% CI: 0.46-0.78), anxiety (OR: 0.61, 95% CI: 0.42-0.86) and psychological distress (OR: 0.60, 95% CI: 0.45-0.79) compared with those with the lowest adherence. When the association with components of Mediterranean diet was examined, we found that high intake of fruits and vegetables was associated with a lower odds of depression, anxiety and psychological distress. In contrast, high intake of grains was positively associated with depression, anxiety and psychological distress. Conclusion We found evidence indicating an inverse association between adherence to Mediterranean dietary pattern and odds of psychological disorders including depression, anxiety and psychological distress.
C1 [Sadeghi, Omid] Univ Tehran Med Sci, Students Sci Res Ctr, Tehran, Iran.
   [Sadeghi, Omid; Esmaillzadeh, Ahmad] Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Community Nutr, POB 14155-6117, Tehran, Iran.
   [Keshteli, Ammar Hassanzadeh] Univ Alberta, Dept Med, Edmonton, AB, Canada.
   [Afshar, Hamid] Isfahan Univ Med Sci, Psychosomat Res Ctr, Esfahan, Iran.
   [Esmaillzadeh, Ahmad] Univ Tehran Med Sci, Obes & Eating Habits Res Ctr, Endocrinol & Metab Mol Cellular Sci Inst, Tehran, Iran.
   [Esmaillzadeh, Ahmad] Isfahan Univ Med Sci, Sch Nutr & Food Sci, Dept Community Nutr, Esfahan, Iran.
   [Adibi, Peyman] Isfahan Univ Med Sci, Integrat Funct Gastroenterol Res Ctr, Esfahan, Iran.
C3 Tehran University of Medical Sciences; Tehran University of Medical
   Sciences; University of Alberta; Isfahan University of Medical Sciences;
   Tehran University of Medical Sciences; Isfahan University of Medical
   Sciences; Isfahan University of Medical Sciences
RP Keshteli, AH (corresponding author), Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Community Nutr, POB 14155-6117, Tehran, Iran.
EM a-esmaillzadeh@tums.ac.ir
RI Keshteli, Ammar/K-7473-2012; Sadeghi, Omid/AAM-9006-2020; Esmaillzadeh,
   Ahmad/N-5704-2014; Adibi Sedeh, Peyman/AAJ-4582-2020
OI Esmaillzadeh, Ahmad/0000-0002-8735-6047; Adibi Sedeh,
   Peyman/0000-0001-6411-5235
FU Isfahan University of Medical Sciences; Students' Scientific Research
   Center, Tehran University of Medical Sciences, Tehran, Iran
   [98-01-61-41559]
FX The study was financially supported by Isfahan University of Medical
   Sciences in collaboration with Students' Scientific Research Center,
   Tehran University of Medical Sciences, Tehran, Iran (with code of
   98-01-61-41559) as well.
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NR 63
TC 102
Z9 103
U1 2
U2 41
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1028-415X
EI 1476-8305
J9 NUTR NEUROSCI
JI Nutr. Neurosci.
PD APR 3
PY 2021
VL 24
IS 4
BP 248
EP 259
DI 10.1080/1028415X.2019.1620425
EA JUN 2019
PG 12
WC Neurosciences; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Nutrition & Dietetics
GA QX5BN
UT WOS:000472457100001
PM 31185883
DA 2025-06-11
ER

PT J
AU Gao, WQ
   Deng, ZF
   Cai, XA
   Zhang, D
   Xiao, H
   Zhang, XY
AF Gao, Wenqi
   Deng, Zhifang
   Cai, Xiaonan
   Zhang, Dan
   Xiao, Han
   Zhang, Xiangyang
TI Gender differences in prevalence and clinical correlates of anxiety in
   first-episode and drug-naïve patients with major depressive disorder
   comorbid with metabolic syndrome
SO BMC PSYCHIATRY
LA English
DT Article
DE Metabolic syndrome; Anxiety; First-episode and drug-naive major
   depressive disorder; Chinese han; Gender differences
ID MENTAL-HEALTH SURVEY; ANXIOUS DEPRESSION; ASSOCIATION; RISK; SEX;
   SCHIZOPHRENIA; METAANALYSIS; POPULATION; DEFINITION; SYMPTOMS
AB BackgroundAlthough gender differences in major depressive disorder (MDD) have been widely reported, there has not been much focus on gender differences in comorbidity. In patients with MDD and comorbid metabolic syndrome (Mets), the goal of this study was to investigate potential gender differences in the prevalence and clinical correlates of concomitant anxiety.MethodsSeven hundred and ninety-four first-episode and drug-naive patients (FEDN) patients with MDD and comorbid Mets were recruited. For each patient, sociodemographic data, thyroid function indicators, and Mets parameters were acquired. Each participant completed the 14-item Hamilton Assessment Scale for Anxiety (HAMA) and the 17-item Hamilton Assessment Scale for Depression (HAMD).ResultsThere were no gender differences in the prevalence of anxiety in patients with MDD and comorbid Mets. Female patients with MDD had a shorter duration of illness. Correlation analysis showed that HAMD score, TSH, TgAb, and TPOAb were associated with anxiety prevalence in female patients, whereas anxiety onset in male patients was only associated with TSH, TgAb, and TPOAb levels. In addition, multiple logistic regression analysis showed that TSH and TgAb predicted anxiety in male patients, whereas HAMD score and age of onset significantly predicted anxiety in female patients.LimitationsCross-sectional design and no control for anxiety-related factors.ConclusionsOur study showed no gender differences in the prevalence of anxiety in patients with MDD and comorbid Mets. HAMD score was associated with anxiety in female patients, whereas TSH, TgAb, and TPOAb were associated with anxiety in male patients.
C1 [Gao, Wenqi; Cai, Xiaonan; Xiao, Han] Huazhong Univ & Technol, Wuhan Childrens Hosp, Wuhan Maternal & Child Healthcare Hosp, Inst Maternal & Child Hlth, Wuhan 430015, Hubei, Peoples R China.
   [Deng, Zhifang] Huazhong Univ Sci & Technol, Cent Hosp Wuhan, Tongji Med Coll, Dept Pharm, Wuhan 430030, Peoples R China.
   [Zhang, Dan] Huazhong Univ & Technol, Wuhan Childrens Hosp, Wuhan Maternal & Child Healthcare Hosp, Tongji Med Coll,Woman Dept Community, Wuhan 430015, Hubei, Peoples R China.
   [Zhang, Xiangyang] Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China.
   [Zhang, Xiangyang] Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China.
C3 Huazhong University of Science & Technology; Huazhong University of
   Science & Technology; Huazhong University of Science & Technology;
   Chinese Academy of Sciences; University of Chinese Academy of Sciences,
   CAS
RP Xiao, H (corresponding author), Huazhong Univ & Technol, Wuhan Childrens Hosp, Wuhan Maternal & Child Healthcare Hosp, Inst Maternal & Child Hlth, Wuhan 430015, Hubei, Peoples R China.; Zhang, XY (corresponding author), Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China.; Zhang, XY (corresponding author), Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China.
EM tjxiaohan@hust.edu.cn; zhangxy@psych.ac.cn
RI deng, zhifang/GSE-0968-2022; Zhang, Xiangyang/ABC-7380-2022
OI Zhang, Xiangyang/0000-0003-3326-382X
FU National Natural Science Foundation of China
FX Not applicable.
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NR 57
TC 2
Z9 2
U1 3
U2 4
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-244X
J9 BMC PSYCHIATRY
JI BMC Psychiatry
PD FEB 22
PY 2024
VL 24
IS 1
AR 156
DI 10.1186/s12888-024-05574-w
PG 8
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychiatry
GA JJ1B1
UT WOS:001172694800004
PM 38388343
OA gold
DA 2025-06-11
ER

PT J
AU Rosenthal, T
   Touyz, RM
   Oparil, S
AF Rosenthal, Talma
   Touyz, Rhian M.
   Oparil, Suzanne
TI Migrating Populations and Health: Risk Factors for Cardiovascular
   Disease and Metabolic Syndrome
SO CURRENT HYPERTENSION REPORTS
LA English
DT Review
DE Immigration; Refugees; Cardiovascular disease; Diabetes; Obesity; Health
   care; Psychosocial stress
ID VITAMIN-D DEFICIENCY; PHYSICAL-ACTIVITY; IMMIGRANTS; REFUGEES; MIGRANTS;
   HYPERTENSION; ADOLESCENTS; PREVALENCE; CHILDREN; OBESITY
AB Purpose of Review To summarize results of recent studies of migrants in Europe and North America and ongoing efforts to adapt strategies to provide them with inclusive sensitive health care. Recent Findings Major predisposing factors for developing hypertension, obesity, diabetes, and the metabolic syndrome in migrating populations and refugees were identified. Susceptibility to the metabolic syndrome is predominantly due to environmental factors and psychological stress. Acculturation also contributes to the emergence of cardiovascular (CV) risk factors in first-generation adult immigrants. Increased risk for later development of hypertension and dyslipidemia has also been detected in adolescent immigrants. Targets for public health efforts were based on data that show important differences in CV risk factors and prevalence of the metabolic syndrome among ethnic immigrant groups. Studies in young adults focused on lifestyle and dietary behaviors and perceptions about weight and body image, while the focus for older adults was end-of-life issues. Two important themes have emerged: barriers to health care, with a focus on cultural and language barriers, and violence and its impact on immigrants' mental health.
C1 [Rosenthal, Talma] Tel Aviv Univ, Sackler Sch Med, Dept Physiol & Pharmacol, Tel Aviv, Israel.
   [Touyz, Rhian M.] McGill Univ, Res Inst, Hlth Ctr, Montreal, PQ, Canada.
   [Oparil, Suzanne] Univ Alabama Birmingham, Dept Med, Div Cardiovasc Dis, Vasc Biol & Hypertens Program, 1720 2nd Ave South, Birmingham, AL 35294 USA.
C3 Tel Aviv University; Sackler Faculty of Medicine; McGill University;
   University of Alabama System; University of Alabama Birmingham
RP Oparil, S (corresponding author), Univ Alabama Birmingham, Dept Med, Div Cardiovasc Dis, Vasc Biol & Hypertens Program, 1720 2nd Ave South, Birmingham, AL 35294 USA.
EM soparil@uabmc.edu
RI Touyz, Rhian/AAM-3564-2020
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NR 106
TC 37
Z9 40
U1 1
U2 12
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1522-6417
EI 1534-3111
J9 CURR HYPERTENS REP
JI Curr. Hypertens. Rep.
PD SEP
PY 2022
VL 24
IS 9
BP 325
EP 340
DI 10.1007/s11906-022-01194-5
EA JUN 2022
PG 16
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 3T2AR
UT WOS:000811411200003
PM 35704140
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Ehrlich, KB
   Lyle, SM
   Corallo, KL
   Brisson, JM
   Wiggins, ER
   Yu, TY
   Chen, ED
   Miller, GE
   Brody, GH
AF Ehrlich, Katherine B.
   Lyle, Sarah M.
   Corallo, Kelsey L.
   Brisson, Julie M.
   Wiggins, Elizabeth R.
   Yu, Tianyi
   Chen, Edith
   Miller, Gregory E.
   Brody, Gene H.
TI Socioeconomic disadvantage and high-effort coping in childhood: evidence
   of skin-deep resilience
SO JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY
LA English
DT Article
DE Skin-deep resilience; cardiometabolic risk; internalizing symptoms;
   socioeconomic status risk; high-effort coping
ID JOHN HENRYISM; METABOLIC SYNDROME; AFRICAN-AMERICANS; RISK; CHILDREN;
   ADOLESCENTS; DEPRESSION; HEALTH
AB BackgroundLow socioeconomic status (SES) is a risk factor for poor outcomes across development. Recent evidence suggests that, although psychosocial resilience among youth living in low-SES households is common, such expressions of resilience may not extend to physical health. Questions remain about when these diverging mental and physical health trajectories emerge. The current study hypothesized that skin-deep resilience - a pattern wherein socioeconomic disadvantage is linked to better mental health but worse physical health for individuals with John Henryism high-effort coping - is already present in childhood. MethodsAnalyses focus on 165 Black and Latinx children (M-age = 11.5) who were free of chronic disease and able to complete study procedures. Guardians provided information about their SES. Children reported on their John Henryism high-effort coping behaviors. They also provided reports of their depressed and anxious mood, which were combined into a composite of internalizing symptoms. Children's cardiometabolic risk was captured as a composite reflecting high levels of systolic or diastolic blood pressure, waist circumference, HbA1c, triglycerides, and low high-density lipoprotein cholesterol. ResultsAmong youth who reported using John Henryism high-effort coping, SES risk was unrelated to internalizing symptoms and was positively associated with cardiometabolic risk. In contrast, for youth who did not engage in high-effort coping, SES risk was positively associated with internalizing symptoms and was unrelated to cardiometabolic risk. ConclusionsFor youth with high-effort coping tendencies, socioeconomic disadvantage is linked to cardiometabolic risk. Public health efforts to support at-risk youth must consider both mental and physical health consequences associated with striving in challenging contexts.
C1 [Ehrlich, Katherine B.; Lyle, Sarah M.; Brisson, Julie M.; Wiggins, Elizabeth R.] Univ Georgia, Dept Psychol, Athens, GA USA.
   [Ehrlich, Katherine B.; Yu, Tianyi; Brody, Gene H.] Univ Georgia, Ctr Family Res, Athens, GA USA.
   [Lyle, Sarah M.] Eckerd Coll, Psychol Discipline, St Petersburg, FL USA.
   [Corallo, Kelsey L.] Georgia State Univ, Georgia Hlth Policy Ctr, Atlanta, GA USA.
   [Chen, Edith; Miller, Gregory E.] Northwestern Univ, Dept Psychol, Evanston, IL USA.
   [Chen, Edith; Miller, Gregory E.] Northwestern Univ, Inst Policy Res, Evanston, IL USA.
   [Ehrlich, Katherine B.] Univ Georgia, Dept Psychol, 125 Baldwin St, Athens, GA 30602 USA.
C3 University System of Georgia; University of Georgia; University System
   of Georgia; University of Georgia; University System of Georgia; Georgia
   State University; Northwestern University; Northwestern University;
   University System of Georgia; University of Georgia
RP Ehrlich, KB (corresponding author), Univ Georgia, Dept Psychol, 125 Baldwin St, Athens, GA 30602 USA.
EM kehrlich@uga.edu
RI Wiggins, Elizabeth/KXR-0482-2024; Brisson, Julie/AAD-7904-2022
OI Lyle, Sarah M/0009-0003-5449-9556; Wiggins,
   Elizabeth/0000-0001-7289-1656; Ehrlich, Katherine/0000-0002-8958-6161;
   Brisson, Julie/0000-0002-4747-9747; Miller, Gregory/0000-0002-7217-1082;
   Yu, Tianyi/0000-0003-3087-1504
FU Jacobs Foundation (Early Career Research Fellowship) [2018-1288-07];
   Jacobs Foundation [2018-1288-07]; Brain and Behavior Research Foundation
   [27302]; National Institutes of Health [DP2 MD013947, R01 HD030588, P50
   DA051361]
FX This research was supported by the Jacobs Foundation (Early Career
   Research Fellowship 2018-1288-07), the Brain and Behavior Research
   Foundation (Young Investigator Grant #27302), and grants DP2 MD013947,
   R01 HD030588, and P50 DA051361 from the National Institutes of Health.
   The funding bodies did not play a role in the design or conduct of the
   study. The content of this article is the sole responsibility of the
   authors and does not necessarily represent the official views of the
   funding agencies. Deidentified individual participant data (including
   data dictionaries) will be made available, in addition to study
   protocols, the statistical analysis plan, and the informed consent form.
   The data will be made available upon publication to researchers who
   provide a methodologically sound proposal for use in achieving the goals
   of the approved proposal. Proposals should be submitted to
   kehrlich@uga.edu. The authors gratefully acknowledge the contributions
   of Dee Vodicka, Manuela Celia-Sanchez, Hyun (Leah) Cha, Anna Langer, Sol
   Moreno, Kristin Rabil, Oreoluwa Badejoh, Daisy Gallegos, Cristhian
   Jimenez, Celaret Perez, and Jordan Rice for their assistance with
   recruitment and data collection. The authors are grateful to the
   families for their participation in this research.Key points Skin-deep
   resilience - a pattern wherein high-effort coping behaviors protect
   individuals against the detrimental effects of socioeconomic
   disadvantage for mental health but amplifies the detrimental effects on
   physical health - has been identified in adult samples, but not in
   studies of children. Among Black/Latinx youth who engaged in John
   Henryism' high-effort coping behaviors, socioeconomic disadvantage was
   unrelated to internalizing symptoms but was positively associated with
   cardiometabolic risk. Our findings demonstrate that skin-deep resilience
   is already present in childhood. Prevention programming, which
   frequently emphasizes goal setting and persistence, should consider
   incorporating mental and physical health promotion strategies to curb
   chronic disease risk.
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NR 27
TC 7
Z9 7
U1 4
U2 32
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0021-9630
EI 1469-7610
J9 J CHILD PSYCHOL PSYC
JI J. Child Psychol. Psychiatry
PD MAR
PY 2024
VL 65
IS 3
DI 10.1111/jcpp.13840
EA MAY 2023
PG 7
WC Psychology, Developmental; Psychiatry; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA HI4N0
UT WOS:000996018200001
PM 37246563
OA hybrid
DA 2025-06-11
ER

PT J
AU Ozturk, BT
   Ozel, F
   Yaras, T
   Ekinci, B
   Oktay, Y
   Aysevener, EO
   Alkin, T
   Direk, N
AF Ozturk, Bilge Targitay
   Ozel, Fatih
   Yaras, Tutku
   Ekinci, Burcu
   Oktay, Yavuz
   Aysevener, Elif Onur
   Alkin, Tunc
   Direk, Nese
TI The Relationship Between Cardiovascular Disease Risk and Major
   Depression
SO NOROPSIKIYATRI ARSIVI-ARCHIVES OF NEUROPSYCHIATRY
LA English
DT Article
DE Cardiometabolic risk factors; depression; psychological stress
ID CORONARY-HEART-DISEASE; MICROVASCULAR DYSFUNCTION; VASCULAR DEPRESSION;
   SYMPTOMS; WOMEN; ATHEROSCLEROSIS; CALCIFICATION; ASSOCIATION;
   BIOMARKERS; MORTALITY
AB Introduction: Cardiovascular risk in depression has been investigated in small clinical samples and population-based studies revealing inconclusive results. However, cardiovascular risk in drug-naive depressed patients has not been tested extensively. Scores and soluble intercellular adhesion molecule-1 (sICAM-1) levels were used to assess the risk of cardiovascular disease in drug-naive depressed patients and healthy volunteers. Conclusion: There were no significant differences in Framingham Cardiovascular Risk Scores and individually assessed risk variables between patients and healthy controls (HC). Both groups were comparable in terms of sICAM-1. Results: The widely recognized association between cardiovascular risk and major depression might be more prominent in older depressed patients and patients with recurring episodes.
C1 [Ozturk, Bilge Targitay; Ozel, Fatih; Aysevener, Elif Onur; Alkin, Tunc; Direk, Nese] Dokuz Eylul Univ, Dept Psychiat, Med Sch, Izmir, Turkiye.
   [Ozturk, Bilge Targitay] Izmir Cesme Alper Cizgenakat State Hosp, Dept Psychiat, Izmir, Turkiye.
   [Ozel, Fatih] Uppsala Univ, Dept Organismal Biol, Uppsala, Sweden.
   [Yaras, Tutku; Ekinci, Burcu; Oktay, Yavuz] Izmir Biomed & Genome Ctr, Izmir, Turkiye.
   [Oktay, Yavuz] Dokuz Eylul Univ, Dept Med Biol, Med Sch, Izmir, Turkiye.
   [Direk, Nese] Istanbul Univ, Istanbul Fac Med, Dept Psychiat, Istanbul, Turkiye.
   [Direk, Nese] Istanbul Univ, Tip Fak, Ruh Sagligi & Hastaliklari Anabilim Dali, TR-34340 Istanbul, Turkiye.
C3 Dokuz Eylul University; Uppsala University; Izmir Biomedicine & Genome
   Center; Dokuz Eylul University; Istanbul University; Istanbul University
RP Direk, N (corresponding author), Istanbul Univ, Tip Fak, Ruh Sagligi & Hastaliklari Anabilim Dali, TR-34340 Istanbul, Turkiye.
EM nese.direk@istanbul.edu.tr
RI Targıtay Öztürk, Bilge/JCO-3945-2023; YARAS, Tutku/HTQ-0432-2023; Oktay,
   Yavuz/G-4794-2015
OI Oktay, Yavuz/0000-0002-0158-2693; Targitay Ozturk,
   Bilge/0000-0002-8524-5204
FU Dokuz Eylul University Scientific Research Projects (BAP) [2019,
   KB.SAG.009]
FX Financial Disclosure: This current study was supported with a grant from
   the Dokuz Eylul University Scientific Research Projects (BAP) (project
   number: 2019.KB.SAG.009)
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NR 33
TC 1
Z9 1
U1 3
U2 8
PU  TURKISH NEUROPSYCHIATRY ASSOC-TURK NOROPSIKIYATRI  DERNEGI
PI ISTANBUL
PA MESRUTIYET MAH HALASKARGAZI CAD SITE APT NO 128-1 SISLI, ISTANBUL,
   Turkiye
SN 1300-0667
EI 1309-4866
J9 NOROPSIKIYATRI ARS
JI Noropsikiyatri Ars.
PD JUN
PY 2023
VL 60
IS 2
BP 124
EP 128
DI 10.29399/npa.28191
PG 5
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA L2MD4
UT WOS:001021642100006
PM 37287563
OA Green Published
DA 2025-06-11
ER

PT S
AU Huang, TL
   Chen, JF
AF Huang, TL
   Chen, JF
BE Makowski, GS
TI Cholesterol and lipids in depression: Stress,
   hypothalamo-pituitary-adrenocortical axis, and inflammation/immunity
SO ADVANCES IN CLINICAL CHEMISTRY, VOL 39
SE Advances in Clinical Chemistry
LA English
DT Review; Book Chapter
ID LOW SERUM-CHOLESTEROL; HIGH-DENSITY-LIPOPROTEIN; SEROTONIN TRANSPORTER
   GENE; FOAM CELL-FORMATION; INSULIN-RESISTANCE SYNDROME; MAJOR
   DEPRESSION; APOLIPOPROTEIN-E; MYOCARDIAL-INFARCTION; BLOOD CHOLESTEROL;
   ADRENAL AXIS
C1 Chang Gung Mem Hosp, Dept Psychiat, Kaohsiung 833, Taiwan.
   Chang Gung Mem Hosp, Dept Internal Med, Kaohsiung 833, Taiwan.
C3 Chang Gung Memorial Hospital; Chang Gung Memorial Hospital
RP Huang, TL (corresponding author), Chang Gung Mem Hosp, Dept Psychiat, Kaohsiung 833, Taiwan.
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NR 156
TC 23
Z9 25
U1 0
U2 10
PU ELSEVIER ACADEMIC PRESS INC
PI SAN DIEGO
PA 525 B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0065-2423
BN 0-12-010339-7
J9 ADV CLIN CHEM
JI Advan. Clin. Chem.
PY 2005
VL 39
BP 81
EP 105
DI 10.1016/S0065-2423(04)39003-7
PG 25
WC Medical Laboratory Technology
WE Book Citation Index – Science (BKCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA BCT32
UT WOS:000231115200003
PM 16013668
DA 2025-06-11
ER

PT J
AU Brumby, S
   Chandrasekara, A
   McCoombe, S
   Torres, S
   Kremer, P
   Lewandowski, P
AF Brumby, Susan
   Chandrasekara, Ananda
   McCoombe, Scott
   Torres, Susan
   Kremer, Peter
   Lewandowski, Paul
TI Reducing psychological distress and obesity in Australian farmers by
   promoting physical activity
SO BMC PUBLIC HEALTH
LA English
DT Article
ID METABOLIC SYNDROME; ADIPOSE-TISSUE; DEPRESSION; ANXIETY; STRESS;
   CORTISOL; SUICIDE; SCALES; FOOD; QUESTIONNAIRE
AB Background: Studies have confirmed that the rate of mental illness is no higher in rural Australians than that of urban Australians. However, the rate of poor mental health outcomes, and in particular suicide, is significantly raised in rural populations. This is thought to be due to lack of early diagnosis, health service access, the distance-decay effect, poor physical health determinants and access to firearms. Research conducted by the National Centre for Farmer Health between 2004 and 2009 reveals that there is a correlation between obesity and psychological distress among the farming community where suicide rates are recognised as high. Chronic stress overstimulates the regulation of the hypothalamic-pituitary-adrenal (HPA) axis that is associated with abdominal obesity. Increasing physical activity may block negative thoughts, increase social contact, positively influence brain chemistry and improve both physical and mental health. This paper describes the design of the Farming Fit study that aims to identify the effect of physical activity on psychological distress, obesity and health behaviours such as diet patterns and smoking in farm men and women.
   Methods/Design: For this quasi experimental (convenience sample) control intervention study, overweight (Body Mass Index >= 25 kg/m(2)) farm men and women will be recruited from Sustainable Farm Families (TM) (SFF) programs held across Victoria, Australia. Baseline demographic data, health data, depression anxiety stress scale (DASS) scores, dietary information, physical activity data, anthropometric data, blood pressure and biochemical analysis of plasma an salivary cortisol levels will be collected. The intervention group will receive an exercise program and regular phone coaching in order to increase their physical activity. Analysis will evaluate the impact of the intervention by longitudinal data (baseline and post intervention) comparison of intervention and control groups.
   Discussion: This study is designed to examine the effect of physical activity on psychological health and other co-morbidities such as obesity, impaired glucose tolerance, hypertension and dyslipidaemia within a high-risk cohort. The outcomes of this research will be relevant to further research and service delivery programs, in particular those tailored to rural communities.
   Trial registrationACTRN12610000827033
C1 [Brumby, Susan; Chandrasekara, Ananda; McCoombe, Scott] Western Dist Hlth Serv, Natl Ctr Farmer Hlth, Hamilton, Vic 3300, Australia.
   [Brumby, Susan; Chandrasekara, Ananda; McCoombe, Scott; Lewandowski, Paul] Deakin Univ, Sch Med, Geelong, Vic 3217, Australia.
   [Torres, Susan] Deakin Univ, Sch Exercise & Nutr Sci, Burwood, Vic 3125, Australia.
   [Kremer, Peter] Deakin Univ, Sch Psychol, Geelong, Vic 3217, Australia.
C3 Deakin University; Deakin University; Deakin University
RP Brumby, S (corresponding author), Western Dist Hlth Serv, Natl Ctr Farmer Hlth, Hamilton, Vic 3300, Australia.
EM susan.brumby@deakin.edu.au
RI Chandrasekara, Ananda/AAV-4623-2021; Kremer, Peter/I-8202-2019
OI Kremer, Peter/0000-0003-2476-1958; McCoombe, Scott/0000-0001-6717-7511;
   Brumby, Susan/0000-0001-6332-3374; Chandrasekara, Prof.
   Ananda/0000-0003-0947-6083
FU beyondblue, Victorian Centre of Excellence (bbVCoE) in Depression and
   Related Disorders [2009/215]
FX We would like to acknowledge the generous funding of the beyondblue,
   Victorian Centre of Excellence (bbVCoE) in Depression and Related
   Disorders (grant reference no. 2009/215). The authors also wish to
   acknowledge the input of Exercise Physiologist Jason Thomas from
   Vitality Rehab Pty Ltd and Research Assistant Hannah Simkin from the
   National Centre for Farmer Health.
CR [Anonymous], 2010, EXTENS FARMING SYST
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NR 52
TC 35
Z9 41
U1 2
U2 42
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2458
J9 BMC PUBLIC HEALTH
JI BMC Public Health
PD MAY 23
PY 2011
VL 11
AR 362
DI 10.1186/1471-2458-11-362
PG 7
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA 779PP
UT WOS:000291792100001
PM 21600058
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Thomsen, CF
   Dreier, R
   Goharian, TS
   Goetze, JP
   Andersen, LB
   Faber, J
   Ried-Larsen, M
   Grontved, A
   Jeppesen, JL
AF Thomsen, Camilla F.
   Dreier, Rasmus
   Goharian, Tina S.
   Goetze, Jens P.
   Andersen, Lars B.
   Faber, Jens
   Ried-Larsen, Mathias
   Grontved, Anders
   Jeppesen, Jorgen L.
TI Association of copeptin, a surrogate marker for arginine vasopressin
   secretion, with insulin resistance: Influence of adolescence and
   psychological stress
SO PEPTIDES
LA English
DT Article
DE Arginine vasopressin; Copeptin; Depression; Insulin; Insulin resistance;
   Psychological stress
ID PROATRIAL NATRIURETIC PEPTIDE; PLASMA COPEPTIN; METABOLIC SYNDROME;
   BLOOD-PRESSURE; GLUCOSE; CHILDREN; OBESITY; DEPRESSION
AB In middle-aged and elderly individuals, circulating copeptin concentrations, a surrogate marker for arginine vasopressin (AVP) secretion, associates with insulin resistance (IR). Whether this association is present in adolescents and young adults is unclear. Because psychological stress associates with higher circulating copeptin concentrations and IR, it has been speculated that increased AVP secretion could be a link between psychological stress and IR. We measured plasma copeptin concentrations in 351 14-16-year-old adolescents and 617 20-28-year-old young adults from the Danish site of the European Youth Heart Study, a population-based cardiovascular risk factor study in adolescents and young adults. IR was determined by the homeostatic model assessment method. Among the young adults, we used symptoms of depression, evaluated by means of the Major Depression Inventory (MDI) scale, as a measure of psychological stress. We applied linear regressions to examine associations, expressed as unstandardized regression coefficients (B) with 95% confidence intervals (CIs), between variables of interest, stratified by age group and adjusting for age, sex and Tanner stages. Copeptin and IR were log-transformed. Among the young adults, copeptin associated with IR (B (95% CI)= 0.19 (0.11 to 0.27), P < 0.001). This association was not found among the adolescents (B= -0.01 (-0.12 to 0.09), P = 0.78). MDI score associated with IR (B = 0.010 (0.004 to 0.016), P < 0.001) and copeptin (B = 0.010 (0.004 to 0.015); P < 0.002) in the young adults. Adjusted for copeptin, the strength of the association between MDI score and IR somewhat diminished (to B = 0.008). In conclusion, adolescence and psychological stress appear to influence the association between copeptin and IR.
C1 [Thomsen, Camilla F.; Dreier, Rasmus; Goharian, Tina S.; Jeppesen, Jorgen L.] Univ Copenhagen, Amager & Hvidovre Hosp Glostrup, Dept Med, Valdemar Hansens Vej 1-23, DK-2600 Glostrup, Denmark.
   [Dreier, Rasmus] Univ Copenhagen, Rigshosp Glostrup, Dept Clin Physiol Nucl Med & PET, Glostrup, Denmark.
   [Goetze, Jens P.] Univ Copenhagen, Dept Clin Biochem, Rigshosp Blegdamsvej, Copenhagen, Denmark.
   [Andersen, Lars B.] Western Norway Univ Appl Sci, Fac Educ Arts & Sport, Campus Sogndal, Bergen, Norway.
   [Andersen, Lars B.] Norwegian Sch Sport Sci, Dept Sports Med, Oslo, Norway.
   [Faber, Jens; Jeppesen, Jorgen L.] Univ Copenhagen, Herlev & Gentofte Hosp, Endocrine Unit, Dept Med O, Herlev, Denmark.
   [Faber, Jens] Univ Copenhagen, Fac Hlth & Med Sci, Copenhagen, Denmark.
   [Ried-Larsen, Mathias; Grontved, Anders] Univ Southern Denmark, Dept Sport Sci & Clin Biomech, Res Unit Exercise Epidemiol, Ctr Res Childhood Hlth, Odense, Denmark.
C3 University of Copenhagen; University of Copenhagen; University of
   Copenhagen; Rigshospitalet; Western Norway University of Applied
   Sciences; Norwegian School of Sport Sciences; University of Copenhagen;
   University of Copenhagen; University of Southern Denmark
RP Thomsen, CF (corresponding author), Univ Copenhagen, Amager & Hvidovre Hosp Glostrup, Dept Med, Valdemar Hansens Vej 1-23, DK-2600 Glostrup, Denmark.
EM allimac_fjord@hotmail.com
RI Grøntved, Anders/AAA-8025-2022; Ried-Larsen, Mathias/GPX-7640-2022
OI Ried-Larsen, Mathias/0000-0002-8388-5291; Jeppesen,
   Jorgen/0000-0003-4320-8015; Grontved, Anders/0000-0003-1584-679X
FU Danish Council for Strategic Research; Danish Heart Foundation; Danish
   Health Fund
FX The European Youth Heart Study obtained funding from the Danish Council
   for Strategic Research, the Danish Heart Foundation and the Danish
   Health Fund. The funding sources was not involved in the study.
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NR 40
TC 9
Z9 9
U1 0
U2 2
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0196-9781
EI 1873-5169
J9 PEPTIDES
JI Peptides
PD MAY
PY 2019
VL 115
BP 8
EP 14
DI 10.1016/j.peptides.2019.02.005
PG 7
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism;
   Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism;
   Pharmacology & Pharmacy
GA HW3PE
UT WOS:000466604400002
PM 30779927
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Suchday, S
   Bellehsen, M
   Friedberg, JP
   Almeida, M
   Kaplan, E
AF Suchday, Sonia
   Bellehsen, Mayer
   Friedberg, Jennifer P.
   Almeida, Maureen
   Kaplan, Erica
TI Clustering of cardiac risk factors associated with the metabolic
   syndrome and associations with psychosocial distress in a young Asian
   Indian population
SO JOURNAL OF BEHAVIORAL MEDICINE
LA English
DT Article
DE Young Asian Indian; Metabolic syndrome (MetS); Factor analysis; Stress;
   Trait anger; Trait anxiety
ID INSULIN-RESISTANCE SYNDROME; NUTRITION EXAMINATION SURVEY; 3RD
   NATIONAL-HEALTH; CARDIOVASCULAR RISK; MYOCARDIAL-INFARCTION;
   DEVELOPING-COUNTRIES; SYNDROME VARIABLES; SOUTH ASIANS; PREVALENCE;
   ADOLESCENTS
AB The metabolic syndrome is a precursor for coronary heart disease. However, its pathophysiology is not clear, its phenotypic expression may vary by region; also, the phenotypic manifestation may be exacerbated by psychosocial distress and family history. The purpose of the current study was to assess the factor structure of the metabolic syndrome in young urban Asian Indians. Asian Indian youth (N = 112) were evaluated for body mass index (BMI), waist-hip ratio, blood pressure (systolic: SBP; diastolic: DBP), blood sugar, triglycerides, cholesterol, insulin, psychosocial distress and family health history. Factor analyses were computed on components of the metabolic syndrome. Three factors were identified for the entire sample: hemodynamic-obesity (SBP, DBP, waist-hip ratio), Lipid (cholesterol, triglyceride), and insulin-obesity (blood sugar, BMI, insulin). Similar to previous research with this population, three distinct factors with no overlap were identified. Factors did not correlate with psychosocial distress or family history. Lack of correlation with family history and psychosocial distress may be a function of the young age and demographics of the sample.
C1 [Suchday, Sonia] Yeshiva Univ, Ferkauf Grad Sch Psychol, Albert Einstein Coll Med, Bronx, NY 10461 USA.
   [Bellehsen, Mayer] Zucker Hillside Hosp, North Shore Long Isl Jewish Hlth Syst, Glen Oaks, NY USA.
   [Friedberg, Jennifer P.] NYU, Sch Med, VA New York Harbor Healthcare Syst, New York, NY USA.
   [Almeida, Maureen] St Xaviers Coll, Bombay, Maharashtra, India.
   [Kaplan, Erica] Yeshiva Univ, Ferkauf Grad Sch Psychol, Bronx, NY 10461 USA.
C3 Yeshiva University; Montefiore Medical Center; Albert Einstein College
   of Medicine; Northwell Health; New York University; St. Xavier's College
   Mumbai; Yeshiva University
RP Suchday, S (corresponding author), Yeshiva Univ, Ferkauf Grad Sch Psychol, Albert Einstein Coll Med, 1165 Morris Pk Ave, Bronx, NY 10461 USA.
EM ssuchday@aecom.yu.edu
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NR 73
TC 2
Z9 2
U1 0
U2 7
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0160-7715
EI 1573-3521
J9 J BEHAV MED
JI J. Behav. Med.
PD AUG
PY 2014
VL 37
IS 4
BP 725
EP 735
DI 10.1007/s10865-013-9521-x
PG 11
WC Psychology, Clinical
WE Social Science Citation Index (SSCI)
SC Psychology
GA AL4OV
UT WOS:000339113200014
PM 23775637
DA 2025-06-11
ER

PT J
AU Knappe, F
   Filippou, K
   Hatzigeorgiadis, A
   Morres, ID
   Tzormpatzakis, E
   Havas, E
   Seelig, H
   Colledge, F
   Ludyga, S
   Meier, M
   de Quervain, D
   Theodorakis, Y
   von Känel, R
   Pühse, U
   Gerber, M
AF Knappe, Florian
   Filippou, Konstantinia
   Hatzigeorgiadis, Antonis
   Morres, Ioannis D.
   Tzormpatzakis, Emmanouil
   Havas, Elsa
   Seelig, Harald
   Colledge, Flora
   Ludyga, Sebastian
   Meier, Marianne
   de Quervain, Dominique
   Theodorakis, Yannis
   von Kanel, Roland
   Puhse, Uwe
   Gerber, Markus
TI Psychological well-being, mental distress, metabolic syndrome, and
   associated factors among people living in a refugee camp in Greece: a
   cross-sectional study
SO FRONTIERS IN PUBLIC HEALTH
LA English
DT Article
DE prevalence; physical health; non-communicable disease; PTSD; stress;
   migrant; fitness
ID GENERALIZED ANXIETY DISORDER; INSOMNIA SEVERITY INDEX; PERCEIVED STRESS
   SCALE; ARABIC VERSION; HEALTH; VALIDITY; RELIABILITY; VALIDATION;
   FITNESS; EXERCISE
AB BackgroundForcibly displaced people face various challenges and are therefore at higher risk of being affected by mental and physiological distress. The present study aimed to determine levels of psychological well-being, PTSD symptom severity, metabolic syndrome, and associated factors among forcibly displaced people in Greece in response to WHO's call for evidence-based public health policies and programs for forcibly displaced people. MethodsWe conducted a cross-sectional study among n = 150 (50% women) forcibly displaced people originating from Sub-Sahara Africa and Southwest Asia living in a Greek refugee camp. Self-report questionnaires were used to assess psychological well-being, symptoms of PTSD, depression, generalized anxiety disorder and insomnia, perceived stress, headache, and perceived fitness. Cardiovascular risk markers were assessed to determine metabolic syndrome, and cardiorespiratory fitness was measured with the & ANGS;strand-Rhyming Test of Maximal Oxygen Uptake. ResultsThe prevalence of mental distress and physiological disorders was overall elevated. Only 53.0% of participants rated their psychological well-being as high. Altogether, 35.3% scored above the clinical cut-off for PTSD, 33.3% for depression, 27.9% for generalized anxiety disorder, and 33.8% for insomnia. One in four (28.8%) participants met criteria for metabolic syndrome. While the prevalence of moderate or severe insomnia symptoms and metabolic syndrome differed little from the global population, the risk of being affected by mental distress was markedly increased. In multivariable analysis, higher perceived fitness was associated with higher psychological well-being (OR = 1.35, p = 0.003) and a decreased likelihood for metabolic syndrome (OR = 0.80, p = 0.031). Participants with elevated psychiatric symptoms were less likely to report high psychological well-being (OR = 0.22, p = 0.003) and had increased odds for higher PTSD severity (OR = 3.27, p = 0.034). Increased stress perception was associated with higher PTSD symptoms (OR = 1.13, p = 0.002). ConclusionThere is an elevated risk for mental distress compared to the global population and an overall high mental and physiological burden among people living in a Greek refugee camp. The findings underpin the call for urgent action. Policies should aim to reduce post-migration stressors and address mental health and non-communicable diseases by various programs. Sport and exercise interventions may be a favorable add-on, given that perceived fitness is associated with both mental and physiological health benefits.
C1 [Knappe, Florian; Seelig, Harald; Ludyga, Sebastian; Puhse, Uwe; Gerber, Markus] Univ Basel, Dept Sport Exercise & Hlth, Basel, Switzerland.
   [Filippou, Konstantinia; Hatzigeorgiadis, Antonis; Tzormpatzakis, Emmanouil; Havas, Elsa; Theodorakis, Yannis] Univ Thessaly, Dept Phys Educ & Sport Sci, Trikala, Greece.
   [Morres, Ioannis D.] Univ Thessaly, Dept Nutr & Dietet, Trikala, Greece.
   [Colledge, Flora] Univ Lucerne, Dept Hlth Sci & Med, Luzern, Switzerland.
   [Meier, Marianne] Univ Bern, Interdisciplinary Ctr Gender Studies, Bern, Switzerland.
   [de Quervain, Dominique] Univ Basel, Div Cognit Neurosci, Basel, Switzerland.
   [von Kanel, Roland] Univ Zurich, Univ Hosp Zurich, Dept Consultat Liaison Psychiat & Psychosomat Med, Zurich, Switzerland.
C3 Swiss School of Public Health (SSPH+); University of Basel; University
   of Thessaly; University of Thessaly; University of Lucerne; University
   of Bern; University of Basel; University of Zurich; University Zurich
   Hospital
RP Knappe, F (corresponding author), Univ Basel, Dept Sport Exercise & Hlth, Basel, Switzerland.
EM florian.knappe@unibas.ch
RI Theodorakis, Yannis/HMO-5490-2023; Gerber, Markus/H-8654-2014; Morres,
   Ioannis/AAC-7494-2019; von Känel, Roland/B-1811-2019; Knappe,
   Florian/HNI-8058-2023; Seelig, Harald/AAH-6584-2020; Ludyga,
   Sebastian/H-9316-2019
OI Morres, Ioannis D./0000-0001-9103-2910; Seelig,
   Harald/0000-0002-2178-4807; Ludyga, Sebastian/0000-0002-3905-7894;
   Knappe, Florian/0000-0002-5565-7232; Tzormpatzakis,
   Manos/0009-0005-8435-0917
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NR 102
TC 6
Z9 6
U1 3
U2 9
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 2296-2565
J9 FRONT PUBLIC HEALTH
JI Front. Public Health
PD JUN 16
PY 2023
VL 11
AR 1179756
DI 10.3389/fpubh.2023.1179756
PG 16
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA K4YD4
UT WOS:001016502900001
PM 37397726
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Civieri, G
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   Qamar, I
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   Armoundas, AA
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   Pitman, RK
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   Wasfy, JH
   Smoller, JW
   Iliceto, S
   Goldstein, J
   Gebhard, C
   Osborne, MT
   Tawakol, A
AF Civieri, Giovanni
   Abohashem, Shady
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   Aldosoky, Wesam
   Qamar, Iqra
   Hanlon, Erin
   Choi, Karmel W.
   Shin, Lisa M.
   Rosovsky, Rachel P.
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   Lau, Hui Chong
   Armoundas, Antonis A.
   Seligowski, Antonia V.
   Turgeon, Sarah M.
   Pitman, Roger K.
   Tona, Francesco
   Wasfy, Jason H.
   Smoller, Jordan W.
   Iliceto, Sabino
   Goldstein, Jill
   Gebhard, Catherine
   Osborne, Michael T.
   Tawakol, Ahmed
TI Anxiety and Depression Associated With Increased Cardiovascular Disease
   Risk Through Accelerated Development of Risk Factors
SO JACC-ADVANCES
LA English
DT Article
DE amygdala; cardiometabolic; mental health; neuro immune; prevention; sex
   differences
ID CORONARY-HEART-DISEASE; NEUROBIOLOGICAL ACTIVITY; RATE-VARIABILITY;
   PRIMARY-CARE; INFLAMMATION; SYMPTOMS; PREVALENCE; TRENDS; SEX
AB BACKGROUND Prior studies have incompletely assessed whether the development of cardiometabolic risk factors (CVDRF) (hypertension, hyperlipidemia, and diabetes mellitus) mediates the association between anxiety and depression (anxiety/depression) and cardiovascular disease (CVD). OBJECTIVES The authors aimed to evaluate the following: 1) the association between anxiety/depression and incident CVDRFs and whether this association mediates the increased CVD risk; and 2) whether neuro-immune mechanisms and age and sex effects may be involved. METHODS Using a retrospective cohort design, Mass General Brigham Biobank subjects were followed for 10 years. Presence and timing of anxiety/depression, CVDRFs, and CVD were determined using ICD codes. Stress-related neural activity, chronic inflammation, and autonomic function were measured by the assessment of amygdalar-to-cortical activity ratio, high-sensitivity CRP, and heart rate variability. Multivariable regression and mediation analyses were employed. RESULTS Among 71,214 subjects (median age 49.6 years; 55.3% female), 27,048 (38.0%) developed CVDRFs during follow-up. Pre-existing anxiety/depression associated with increased risk of incident CVDRF (OR: 1.71 [95% CI: 1.59-1.83], P < 0.001) and with a shorter time to their development (beta =-0.486 [95% CI:-0.62 to-0.35], P < 0.001). The development of CVDRFs mediated the association between anxiety/depression and CVD events (log-odds: 0.044 [95% CI: 0.034-0.055], P < 0.05). Neuro-immune pathways contributed to the development of CVDRFs (P < 0.05 each) and significant age and sex effects were noted: younger women experienced the greatest acceleration in the development of CVDRFs after anxiety/depression. CONCLUSIONS Anxiety/depression accelerate the development of CVDRFs. This association appears to be most notable among younger women and may be mediated by stress-related neuro-immune pathways. Evaluations of tailored preventive measures for individuals with anxiety/depression are needed to reduce CVD risk. (c) 2024 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
C1 [Civieri, Giovanni; Abohashem, Shady; Grewal, Simran S.; Aldosoky, Wesam; Qamar, Iqra; Hanlon, Erin; Lau, Hui Chong; Armoundas, Antonis A.; Seligowski, Antonia V.; Osborne, Michael T.; Tawakol, Ahmed] Massachusetts Gen Hosp, Cardiovasc Imaging Res Ctr, Boston, MA USA.
   [Civieri, Giovanni; Abohashem, Shady; Grewal, Simran S.; Aldosoky, Wesam; Qamar, Iqra; Hanlon, Erin; Rosovsky, Rachel P.; Lau, Hui Chong; Seligowski, Antonia V.; Wasfy, Jason H.; Tawakol, Ahmed] Harvard Med Sch, 55 Fruit St,Yawkey 5E, Boston, MA 02114 USA.
   [Civieri, Giovanni; Tona, Francesco; Iliceto, Sabino] Univ Padua, Dept Cardiac Thorac Vasc Sci & Publ Hlth, Padua, Italy.
   [Abohashem, Shady; Grewal, Simran S.; Qamar, Iqra; Wasfy, Jason H.; Osborne, Michael T.; Tawakol, Ahmed] Massachusetts Gen Hosp, Cardiol Div, 55 Fruit St,Yawkey 5E, Boston, MA 02114 USA.
   [Choi, Karmel W.; Seligowski, Antonia V.; Smoller, Jordan W.; Goldstein, Jill] Harvard Med Sch, Dept Psychiat, Boston, MA USA.
   [Choi, Karmel W.; Smoller, Jordan W.] Massachusetts Gen Hosp, Ctr Med, Psychiat & Neurodev Genet Unit, Boston, MA USA.
   [Choi, Karmel W.] Massachusetts Gen Hosp, Ctr Precis Psychiat, Dept Psychiat, Boston, MA USA.
   [Shin, Lisa M.] Tufts Univ, Dept Psychol, Medford, MA USA.
   [Shin, Lisa M.; Pitman, Roger K.] Massachusetts Gen Hosp, Dept Psychiat, Charlestown, MA USA.
   [Shin, Lisa M.; Pitman, Roger K.] Harvard Med Sch, Charlestown, MA USA.
   [Rosovsky, Rachel P.] Massachusetts Gen Hosp, Dept Med, Boston, MA USA.
   [Bollepalli, Sandeep Chandra; Armoundas, Antonis A.] Massachusetts Gen Hosp, Cardiovasc Res Ctr, Boston, MA USA.
   [Armoundas, Antonis A.] MIT, Inst Med Engn & Sci, Cambridge, MA USA.
   [Turgeon, Sarah M.] Amherst Coll, Neurosci Program, Amherst, MA USA.
   [Smoller, Jordan W.] Broad Inst MIT & Harvard, Cambridge, MA USA.
   [Smoller, Jordan W.; Goldstein, Jill] Massachusetts Gen Hosp, Innovat Ctr Sex Differences Med ICON X, Boston, MA USA.
   [Gebhard, Catherine] Univ Hosp Zurich, Dept Nucl Med, Zurich, Switzerland.
   [Gebhard, Catherine] Univ Zurich, Ctr Mol Cardiol, Zurich, Switzerland.
   [Gebhard, Catherine] Univ Hosp Inselspital Bern, Dept Cardiol, Bern, Switzerland.
C3 Harvard University; Harvard University Medical Affiliates; Massachusetts
   General Hospital; Harvard University; Harvard Medical School; University
   of Padua; Harvard University; Harvard University Medical Affiliates;
   Massachusetts General Hospital; Harvard University; Harvard Medical
   School; Harvard University; Harvard University Medical Affiliates;
   Massachusetts General Hospital; Harvard University; Harvard University
   Medical Affiliates; Massachusetts General Hospital; Tufts University;
   Harvard University; Harvard University Medical Affiliates; Massachusetts
   General Hospital; Harvard University; Harvard University Medical
   Affiliates; Massachusetts General Hospital; Harvard University; Harvard
   University Medical Affiliates; Massachusetts General Hospital;
   Massachusetts Institute of Technology (MIT); Amherst College; Harvard
   University; Massachusetts Institute of Technology (MIT); Broad
   Institute; Harvard University; Harvard University Medical Affiliates;
   Massachusetts General Hospital; University of Zurich; University Zurich
   Hospital; University of Zurich; University of Bern; University Hospital
   of Bern
RP Tawakol, A (corresponding author), Harvard Med Sch, 55 Fruit St,Yawkey 5E, Boston, MA 02114 USA.; Tawakol, A (corresponding author), Massachusetts Gen Hosp, Cardiol Div, 55 Fruit St,Yawkey 5E, Boston, MA 02114 USA.
EM atawakol@mgh.harvard.edu
RI Rosovsky, Rachel/AAH-1166-2021; Civieri, Giovanni/HJH-0376-2022;
   Abohashem, Shady/AAH-9851-2020; Seligowski, Antonia/GLV-3861-2022; Lau,
   Hui Chong/JFS-0429-2023; Silverman, Jeremy/AAO-4268-2020
OI Civieri, Giovanni/0000-0002-3076-4787; Rosovsky,
   Rachel/0000-0002-2392-7365
FU NIH [K23HL151909, MH125920]; AHA [23SCISA1143491]; Lung Biotechnologies
FX Dr Osborne has received consulting fees from WCG Clinical for unrelated
   work; and is supported in part by NIH K23HL151909 and AHA
   23SCISA1143491. Dr Tawakol's institution has received grant support from
   Lung Biotechnologies for unrelated work. Dr Seligowski is supported in
   part by NIH MH125920. All other authors have reported that they have no
   relationships relevant to the contents of this paper to disclose.
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NR 49
TC 8
Z9 8
U1 1
U2 3
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
EI 2772-963X
J9 JACC-ADV
JI JACC-Adv.
PD SEP
PY 2024
VL 3
IS 9
AR 101208
DI 10.1016/j.jacadv.2024.101208
PN 1
PG 13
WC Cardiac & Cardiovascular Systems
WE Emerging Sources Citation Index (ESCI)
SC Cardiovascular System & Cardiology
GA 2XO5C
UT WOS:001493708900007
PM 39238850
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Golbidi, S
   Mesdaghinia, A
   Laher, I
AF Golbidi, Saeid
   Mesdaghinia, Azam
   Laher, Ismail
TI Exercise in the Metabolic Syndrome
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Review
ID TUMOR-NECROSIS-FACTOR; HUMAN SKELETAL-MUSCLE; ANGIOTENSIN-ALDOSTERONE
   SYSTEM; VASCULAR SUPEROXIDE-PRODUCTION; SALT-SENSITIVE HYPERTENSION;
   INSULIN-RESISTANCE-SYNDROME; EPICARDIAL ADIPOSE-TISSUE; ACTIVATED
   PROTEIN-KINASE; PLASMA-RENIN ACTIVITY; OXIDATIVE STRESS
AB The metabolic syndrome is a clustering of obesity, diabetes, hyperlipidemia, and hypertension that is occurring in increasing frequency across the global population. Although there is some controversy about its diagnostic criteria, oxidative stress, which is defined as imbalance between the production and inactivation of reactive oxygen species, has a major pathophysiological role in all the components of this disease. Oxidative stress and consequent inflammation induce insulin resistance, which likely links the various components of this disease. We briefly review the role of oxidative stress as a major component of the metabolic syndrome and then discuss the impact of exercise on these pathophysiological pathways. Included in this paper is the effect of exercise in reducing fat-induced inflammation, blood pressure, and improving muscular metabolism.
C1 [Golbidi, Saeid; Laher, Ismail] Univ British Columbia, Fac Med, Dept Anesthesiol Pharmacol & Therapeut, Vancouver, BC V6T 1Z3, Canada.
   [Mesdaghinia, Azam] Kashan Univ Med Sci & Hlth Serv, Physiol Res Ctr, Kashan 87155111, Iran.
C3 University of British Columbia
RP Laher, I (corresponding author), Univ British Columbia, Fac Med, Dept Anesthesiol Pharmacol & Therapeut, Vancouver, BC V6T 1Z3, Canada.
EM ilaher@interchange.ubc.ca
RI Laher, Ismail/X-3323-2019; Mesdaghinia, Azam/G-6474-2017
OI Mesdaghinia, Azam/0000-0002-6222-9615; Laher, Ismail/0000-0002-3917-4417
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NR 185
TC 91
Z9 103
U1 0
U2 5
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PY 2012
VL 2012
AR 349710
DI 10.1155/2012/349710
PG 13
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA 990TX
UT WOS:000307655700001
PM 22829955
OA hybrid, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Licht, CMM
   Vreeburg, SA
   Dortland, AKBV
   Giltay, EJ
   Hoogendijk, WJG
   DeRijk, RH
   Vogelzangs, N
   Zitman, FG
   de Geus, EJC
   Penninx, BWJH
AF Licht, Carmilla M. M.
   Vreeburg, Sophie A.
   Dortland, Arianne K. B. van Reedt
   Giltay, Erik J.
   Hoogendijk, Witte J. G.
   DeRijk, Roel H.
   Vogelzangs, Nicole
   Zitman, Frans G.
   de Geus, Eco J. C.
   Penninx, Brenda W. J. H.
TI Increased Sympathetic and Decreased Parasympathetic Activity Rather Than
   Changes in Hypothalamic-Pituitary-Adrenal Axis Activity Is Associated
   with Metabolic Abnormalities
SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Article
ID HEART-RATE-VARIABILITY; CORTICOTROPIN-RELEASING HORMONE; MAJOR
   DEPRESSIVE DISORDER; SALIVARY CORTISOL; CARDIOVASCULAR-DISEASE;
   PLASMA-CORTISOL; ANXIETY NESDA; STRESS; RISK; HYPERTENSION
AB Context: Stress is suggested to lead to metabolic dysregulations as clustered in the metabolic syndrome, but the underlying biological mechanisms are not yet well understood.
   Objective: We examined the relationship between two main str systems, the autonomic nervous system and the hypothalamic-pituitary-adrenal (HPA) axis, with the metabolic syndrome and its components.
   Design: Thedesignwasbaseline data (yr 2004-2007) of a prospective cohort: the Netherlands Study of Depression and Anxiety (NESDA).
   Setting: The study comprised general community, primary care, andspecialized mental health care.
   Participants: This study included 1883 participants aged 18-65 yr.
   Main Outcome Measures: Autonomic nervous system measures included heart rate, respiratory sinus arrhythmia (RSA; high RSA reflecting high parasympathetic activity), and preejection period (PEP; high PEP reflecting low sympathetic activity). HPA axis measures included the cortisol awakening response, evening cortisol, and a 0.5 mg dexamethasone suppression test as measured in saliva. Metabolic syndrome was based on the updated Adult Treatment Panel III criteria and included high waist circumference, serum triglycerides, blood pressure, serum glucose, and low high-density lipoprotein cholesterol.
   Results: RSA and PEP were both independently negatively associated with the presence of the metabolic syndrome, the number of metabolic dysregulations as well as all individual components except high-density lipoprotein cholesterol (all P < 0.02). Heart rate was positively related to the metabolic syndrome, the number of metabolic dysregulations, and all individual components (all P < 0.001). HPA axis measures were not related to metabolic syndrome or its components.
   Conclusion: Our findings suggest that increased sympathetic and decreased parasympathetic nervous system activity is associated with metabolic syndrome, whereas HPA axis activity is not. (J Clin Endocrinol Metab 95: 2458-2466, 2010)
C1 [Licht, Carmilla M. M.] Vrije Univ Amsterdam, Med Ctr, EMGO Inst, Dept Psychiat, NL-1081 HL Amsterdam, Netherlands.
   [Licht, Carmilla M. M.; Vreeburg, Sophie A.; Hoogendijk, Witte J. G.; Vogelzangs, Nicole; Penninx, Brenda W. J. H.] Vrije Univ Amsterdam, Med Ctr, EMGO Inst Hlth & Care Res, NL-1081 HL Amsterdam, Netherlands.
   [Hoogendijk, Witte J. G.; de Geus, Eco J. C.] Vrije Univ Amsterdam, Med Ctr, NL-1081 HL Amsterdam, Netherlands.
   [de Geus, Eco J. C.] Vrije Univ Amsterdam, Dept Biol Psychol, NL-1081 HL Amsterdam, Netherlands.
   [Dortland, Arianne K. B. van Reedt; Giltay, Erik J.; DeRijk, Roel H.; Zitman, Frans G.; Penninx, Brenda W. J. H.] Leiden Univ, Med Ctr, Dept Psychiat, NL-2300 RC Leiden, Netherlands.
   [Penninx, Brenda W. J. H.] Univ Groningen, Med Ctr, Dept Psychiat, NL-9700 RB Groningen, Netherlands.
C3 Vrije Universiteit Amsterdam; Vrije Universiteit Amsterdam; Vrije
   Universiteit Amsterdam; Vrije Universiteit Amsterdam; Leiden University
   - Excl LUMC; Leiden University; Leiden University Medical Center (LUMC);
   University of Groningen
RP Licht, CMM (corresponding author), Vrije Univ Amsterdam, Med Ctr, EMGO Inst, Dept Psychiat, AJ Ernststr 887, NL-1081 HL Amsterdam, Netherlands.
EM c.licht@vumc.nl
RI Giltay, Erik/AAL-9948-2021; Zitman, Frans/E-7705-2010; Penninx,
   Brenda/S-7627-2017; de Geus, Eco/M-9318-2015
OI Giltay, Erik J./0000-0001-8874-2292; Hoogendijk,
   Witte/0000-0002-0225-4966; de Geus, Eco/0000-0001-6022-2666
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NR 41
TC 185
Z9 201
U1 1
U2 24
PU ENDOCRINE SOC
PI CHEVY CHASE
PA 8401 CONNECTICUT AVE, SUITE 900, CHEVY CHASE, MD 20815-5817 USA
SN 0021-972X
J9 J CLIN ENDOCR METAB
JI J. Clin. Endocrinol. Metab.
PD MAY
PY 2010
VL 95
IS 5
BP 2458
EP 2466
DI 10.1210/jc.2009-2801
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 592DW
UT WOS:000277356700059
PM 20237163
OA Bronze
DA 2025-06-11
ER

PT J
AU Mattei, G
   Padula, MS
   Rioli, G
   Arginelli, L
   Bursi, R
   Bursi, S
   Epifani, AM
   Pingani, L
   Rigatelli, M
   Rosato, FM
   Sacchetti, A
   Galeazzi, GM
   Ferrari, S
AF Mattei, Giorgio
   Padula, Maria Stella
   Rioli, Giulia
   Arginelli, Lodovico
   Bursi, Roberto
   Bursi, Serena
   Epifani, Antonio Matteo
   Pingani, Luca
   Rigatelli, Marco
   Rosato, Francesca Maria
   Sacchetti, Andrea
   Galeazzi, Gian Maria
   Ferrari, Silvia
TI Metabolic Syndrome, Anxiety and Depression in a Sample of Italian
   Primary Care Patients
SO JOURNAL OF NERVOUS AND MENTAL DISEASE
LA English
DT Article
DE Anxiety; depression; metabolic syndrome; primary care; general
   practitioner
ID 3RD NATIONAL-HEALTH; HOSPITAL ANXIETY; PREVALENCE; MULTIMORBIDITY;
   ASSOCIATION; INFLAMMATION; METAANALYSIS; COMORBIDITY; POPULATION;
   FLUOXETINE
AB This cross-sectional study aimed at measuring the correlation and association of anxiety, depression and comorbid anxiety-depression symptoms with metabolic syndrome (MetS) in a sample of Italian primary care patients who attended their General Practitioner clinics over a 1-month period in 2013. The Hospital Anxiety and Depression Scale (HADS) was used to assess anxiety and depressive symptoms. The sample was made up of 129 patients (57% women; mean age, 61 +/- 12 years). The prevalence of MetS varied from 40% (Adult Treatment Panel III-Revised criteria) to 48% (International Diabetes Federation criteria). The prevalence of symptoms of anxiety, depression and comorbid anxiety and depression was, respectively, 26%, 2%, and 15%. MetS (defined according to Adult Treatment Panel III-Revised criteria) was associated with comorbid anxiety-depressive symptoms (odds ratio [OR] = 3.84, 95% confidence interval [CI] = 1.26-11.71), but not with anxiety or depressive symptoms only. Out of the individual components of MetS, enlarged waist circumference was associated with anxiety symptoms (OR = 4.22, 95% CI = 1.56-11.44).
C1 [Mattei, Giorgio; Rioli, Giulia; Rigatelli, Marco; Sacchetti, Andrea; Galeazzi, Gian Maria; Ferrari, Silvia] Univ Modena & Reggio Emilia, Dept Diagnost Clin & Publ Hlth Med, Sect Psychiat, Modena, Italy.
   [Mattei, Giorgio] Univ Modena & Reggio Emilia, Dept Econ, Marco Biagi Fdn, Modena, Italy.
   [Mattei, Giorgio; Bursi, Roberto; Bursi, Serena] Assoc Res Psychiat, Modena, Italy.
   [Padula, Maria Stella; Arginelli, Lodovico; Bursi, Roberto; Epifani, Antonio Matteo; Rosato, Francesca Maria] Local Hlth Agcy Modena, Dept Primary Care, Modena, Italy.
   [Padula, Maria Stella; Bursi, Serena] Univ Modena & Reggio Emilia, Dept Biomed Metab & Neural Sci, Modena, Italy.
   [Padula, Maria Stella] Soc Italiana Med Gen, Florence, Italy.
   [Pingani, Luca] Local Hlth Agcy Reggio Emilia, Human Resources, Modena, Italy.
   [Galeazzi, Gian Maria; Ferrari, Silvia] Local Hlth Agcy Modena, Dept Mental Hlth, Modena, Italy.
C3 Universita di Modena e Reggio Emilia; Universita di Modena e Reggio
   Emilia; Universita di Modena e Reggio Emilia
RP Mattei, G (corresponding author), Policlin Modena, Clin Psichiatr, Via Pozzo 71, I-41124 Modena, Italy.
EM giorgiomattei@alice.it
RI Sacchetti, Andrea/J-5410-2016; PINGANI, LUCA/AAW-5196-2020; Ferrari,
   Silvia/G-5964-2011; Galeazzi, Gian/J-6676-2016
OI Galeazzi, Gian/0000-0003-2706-3362
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NR 47
TC 21
Z9 22
U1 0
U2 5
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0022-3018
EI 1539-736X
J9 J NERV MENT DIS
JI J. Nerv. Ment. Dis.
PD MAY
PY 2018
VL 206
IS 5
BP 316
EP 324
DI 10.1097/NMD.0000000000000807
PG 9
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA GE1UQ
UT WOS:000431002700003
PM 29658910
DA 2025-06-11
ER

PT J
AU Rosenbaum, S
   Stierli, M
   McCullagh, S
   Newby, J
   Ward, PB
   Harvey, S
   Steel, Z
AF Rosenbaum, Simon
   Stierli, Michael
   McCullagh, Steven
   Newby, Jill
   Ward, Philip B.
   Harvey, Samuel
   Steel, Zachary
TI An open trial of theRECONNECTexercise program for NSW Police
   Officers with posttraumatic stress disorder or psychological injury
SO HEALTH PROMOTION JOURNAL OF AUSTRALIA
LA English
DT Article
DE emergency service workers; exercise; mental health; occupational stress;
   physical activity; police; PTSD
ID NATIONAL EPIDEMIOLOGIC SURVEY; PHYSICAL-ACTIVITY; METABOLIC SYNDROME;
   PEOPLE; EXERCISE; ALCOHOL; ANXIETY; METAANALYSIS; COMORBIDITY;
   DEPRESSION
AB Objective Posttraumatic stress disorder (PTSD) and psychological injuries are debilitating health problems facing police officers. There is increasing interest in the role of exercise as an intervention. We aimed to determine the preliminary effectiveness of theRECONNECTexercise program for NSW Police Officers experiencing PTSD or psychological injury. Methods An open trial was conducted between 2016 and 2017 across three NSW sites.RECONNECTconsisted of twice weekly, supervised exercise sessions for three months. Outcomes were assessed at baseline, week 6 and week 12 (intervention completion) and included PTSD symptoms, depression, anxiety and stress, insomnia severity and alcohol use. Data were analysed using linear mixed models. Results: In total, n = 60 Officers were consecutively referred to the program (35% female, mean age 42.0 +/- 8.9 years). The majority had a clinical diagnosis of PTSD (n = 48, 80%). A clinically significant reduction in PTSD (Cohen's d = 0.96), depression (d = 0.71), anxiety (d = 0.55) and stress (d = 0.69) symptoms was found from baseline to week 12. Drop-out and lost to follow-up was high. Higher baseline PTSD severity was associated with an increased likelihood to complete postintervention assessment. Conclusions RECONNECTappears to be effective in reducing symptoms of PTSD. Exercise may be an effective component of PTSD treatment.
C1 [Rosenbaum, Simon; Ward, Philip B.; Harvey, Samuel; Steel, Zachary] Univ New South Wales, Sch Psychiat, Sydney, NSW, Australia.
   [Rosenbaum, Simon; Harvey, Samuel] Univ New South Wales, Black Dog Inst, Sydney, NSW, Australia.
   [Stierli, Michael] New South Wales Police Force, Sydney, NSW, Australia.
   [McCullagh, Steven] South Wales Police Force, Sydney, NSW, Australia.
   [Newby, Jill] Univ New South Wales, Sch Psychol, Sydney, NSW, Australia.
   [Ward, Philip B.] South Western Sydney Local Hlth Dist, Schizophrenia Res Unit, Liverpool, NSW, Australia.
   [Ward, Philip B.] Ingham Inst Appl Med Res, Liverpool, NSW, Australia.
   [Steel, Zachary] Richmond Hosp, St John God Hlth Care, Sydney, NSW, Australia.
C3 University of New South Wales Sydney; Black Dog Institute; University of
   New South Wales Sydney; University of New South Wales Sydney; South
   Western Sydney Local Health District; Ingham Institute for Applied
   Medical Research; St John of God Health Care
RP Rosenbaum, S (corresponding author), UNSW Sydney, Sch Psychiat, Level 1,AGSM Bldg, Sydney, NSW 2052, Australia.
EM s.rosenbaum@unsw.edu.au
RI Harvey, Samuel/B-5638-2011; Rosenbaum, Simon/Y-3241-2019; Steel,
   Zachary/MEQ-2709-2025; Ward, Philip/JCE-6293-2023
OI Steel, Zachary/0000-0002-5048-2920; Harvey, Samuel/0000-0001-9580-3743;
   Ward, Philip/0000-0002-5779-7722; Rosenbaum, Simon/0000-0002-8984-4941
FU NHMRC Fellowship [APP1123336]
FX SR is funded by an NHMRC Fellowship (APP1123336).
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NR 37
TC 5
Z9 5
U1 0
U2 15
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1036-1073
EI 2201-1617
J9 HEALTH PROMOT J AUST
JI Health Promot. J. Aust.
PD JAN
PY 2022
VL 33
IS 1
BP 28
EP 33
DI 10.1002/hpja.406
EA SEP 2020
PG 6
WC Public, Environmental & Occupational Health
WE Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA YJ0OI
UT WOS:000570150600001
PM 33463832
DA 2025-06-11
ER

PT S
AU Silverman, MN
   Sternberg, EM
AF Silverman, Marni N.
   Sternberg, Esther M.
BE DelRey, A
   Welsh, CJ
   Schwarz, MJ
   Besedovsky, HO
TI Glucocorticoid regulation of inflammation and its functional correlates:
   from HPA axis to glucocorticoid receptor dysfunction
SO NEUROIMMUNOMODULATION IN HEALTH AND DISEASE I
SE Annals of the New York Academy of Sciences
LA English
DT Article; Proceedings Paper
CT 8th Congress of the International-Society-for-Neuroimmunomodulation
   (ISNIM)/German Endocrine-Brain-Immune Network (GEBIN)
CY OCT 20-22, 2011
CL Dresden, GERMANY
SP Int Soc Neuro Immuno Modulat (ISNIM), German Endocrine Brain Immune Network (GEBIN)
DE stress; cortisol; cytokines; autoimmune; depression;
   psychoneuroimmunology
ID PITUITARY-ADRENAL AXIS; CORTICOTROPIN-RELEASING HORMONE;
   CENTRAL-NERVOUS-SYSTEM; PSYCHOLOGICAL STRESS; DNA-BINDING; METABOLIC
   SYNDROME; GENE-EXPRESSION; SWEAT PATCHES; BETA-ISOFORM; IMMUNE
AB Enhanced susceptibility to inflammatory and autoimmune disease can be related to impairments in HPA axis activity and associated hypocortisolism, or to glucocorticoid resistance resulting from impairments in local factors affecting glucocorticoid availability and function, including the glucocorticoid receptor (GR). The enhanced inflammation and hypercortisolism that typically characterize stress-related illnesses, such as depression, metabolic syndrome, cardiovascular disease, or osteoporosis, may also be related to increased glucocorticoid resistance. This review focuses on impaired GR function as a molecular mechanism of glucocorticoid resistance. Both genetic and environmental factors can contribute to impaired GR function. The evidence that glucocorticoid resistance can be environmentally induced has important implications for management of stress-related inflammatory illnesses and underscores the importance of prevention and management of chronic stress. The simultaneous assessment of neural, endocrine, and immune biomarkers through various noninvasive methods will also be discussed.
C1 [Silverman, Marni N.; Sternberg, Esther M.] NIMH, Sect Neuroendocrine Immunol & Behav, NIH, Bethesda, MD 20892 USA.
C3 National Institutes of Health (NIH) - USA; NIH National Institute of
   Mental Health (NIMH)
RP Sternberg, EM (corresponding author), NIMH, Sect Neuroendocrine Immunol & Behav, NIH, 10 Ctr Dr,Rm 2D-39,MSC 1350, Bethesda, MD 20892 USA.
EM sternbee@mail.nih.gov
FU NIH, NIMH Division of Intramural Research
FX This work was supported by the NIH, NIMH Division of Intramural
   Research.
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NR 98
TC 519
Z9 605
U1 3
U2 128
PU BLACKWELL SCIENCE PUBL
PI OXFORD
PA OSNEY MEAD, OXFORD OX2 0EL, ENGLAND
SN 0077-8923
BN 978-1-57331-868-6
J9 ANN NY ACAD SCI
JI Ann.NY Acad.Sci.
PY 2012
VL 1261
BP 55
EP 63
DI 10.1111/j.1749-6632.2012.06633.x
PG 9
WC Immunology; Multidisciplinary Sciences; Neurosciences
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Science & Technology - Other Topics; Neurosciences &
   Neurology
GA BDC07
UT WOS:000312537900009
PM 22823394
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Sáez-Lara, MJ
   Robles-Sanchez, C
   Ruiz-Ojeda, FJ
   Plaza-Diaz, J
   Gil, A
AF Jose Saez-Lara, Maria
   Robles-Sanchez, Candido
   Javier Ruiz-Ojeda, Francisco
   Plaza-Diaz, Julio
   Gil, Angel
TI Effects of Probiotics and Synbiotics on Obesity, Insulin Resistance
   Syndrome, Type 2 Diabetes and Non-Alcoholic Fatty Liver Disease: A
   Review of Human Clinical Trials
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE probiotics; randomized clinical trial; obesity; insulin resistance;
   metabolic syndrome X; type 2 diabetes; non-alcoholic fatty liver
   disease; synbiotics
ID LACTOBACILLUS-GASSERI SBT2055; BLOOD MONONUCLEAR-CELLS; DOUBLE-BLIND;
   GUT MICROBIOTA; LIPID PROFILE; METABOLIC SYNDROME; OXIDATIVE STRESS;
   ABDOMINAL ADIPOSITY; YOGURT CONSUMPTION; GENE-EXPRESSION
AB The use of probiotics and synbiotics in the prevention and treatment of different disorders has dramatically increased over the last decade. Both probiotics and synbiotics are well known ingredients of functional foods and nutraceuticals and may provide beneficial health effects because they can influence the intestinal microbial ecology and immunity. The present study reviews the effects of probiotics and synbiotics on obesity, insulin resistance syndrome (IRS), type 2 diabetes (T2D) and non-alcoholic fatty liver disease (NAFLD) in human randomized clinical trials. Select probiotics and synbiotics provided beneficial effects in patients with obesity, mainly affecting the body mass index and fat mass. Some probiotics had beneficial effects on IRS, decreasing the cell adhesion molecule-1 levels, and the synbiotics decreased the insulin resistance and plasma lipid levels. Moreover, select probiotics improved the carbohydrate metabolism, fasting blood glucose, insulin sensitivity and antioxidant status and also reduced metabolic stress in subjects with T2D. Some probiotics and synbiotics improved the liver and metabolic parameters in patients with NAFLD. The oral intake of probiotics and synbiotics as co-adjuvants for the prevention and treatment of obesity, IRS, T2D and NAFLD is partially supported by the data shown in the present review. However, further studies are required to understand the precise mechanism of how probiotics and synbiotics affect these metabolic disorders.
C1 [Jose Saez-Lara, Maria] Univ Granada, Sch Sci, Dept Biochem & Mol Biol 1, E-18071 Granada, Spain.
   [Jose Saez-Lara, Maria; Robles-Sanchez, Candido; Javier Ruiz-Ojeda, Francisco; Plaza-Diaz, Julio; Gil, Angel] Univ Granada, Biomed Res Ctr, Inst Nutr & Food Technol Jose Mataix, Armilla 18100, Spain.
   [Robles-Sanchez, Candido; Javier Ruiz-Ojeda, Francisco; Plaza-Diaz, Julio; Gil, Angel] Univ Granada, Sch Pharm, Dept Biochem & Mol Biol 2, E-18071 Granada, Spain.
   [Javier Ruiz-Ojeda, Francisco; Plaza-Diaz, Julio; Gil, Angel] Univ Granada, Complejo Hosp Univ Granada, Inst Invest Biosanitaria Ibs, E-18014 Granada, Spain.
   [Gil, Angel] Inst Salud Carlos III, CIBEROBN Physiopathol Obes & Nutr CB12 03 30038, Madrid 28029, Spain.
C3 University of Granada; University of Granada; University of Granada;
   University of Granada; Instituto de Investigacion Biosanitaria IBS
   Granada; CIBER - Centro de Investigacion Biomedica en Red; CIBEROBN;
   Instituto de Salud Carlos III
RP Gil, A (corresponding author), Univ Granada, Biomed Res Ctr, Inst Nutr & Food Technol Jose Mataix, Armilla 18100, Spain.; Gil, A (corresponding author), Univ Granada, Sch Pharm, Dept Biochem & Mol Biol 2, E-18071 Granada, Spain.; Gil, A (corresponding author), Univ Granada, Complejo Hosp Univ Granada, Inst Invest Biosanitaria Ibs, E-18014 Granada, Spain.; Gil, A (corresponding author), Inst Salud Carlos III, CIBEROBN Physiopathol Obes & Nutr CB12 03 30038, Madrid 28029, Spain.
EM mjsaez@ugr.es; croblesan@hotmail.com; fruizojeda@ugr.es; jrplaza@ugr.es;
   agil@ugr.es
RI Gil, Angel/L-2275-2014; Ruiz Ojeda, Francisco Javier/D-1228-2016;
   Plaza-Diaz, Julio/C-8094-2016
OI Gil, Angel/0000-0001-7663-0939; Ruiz Ojeda, Francisco
   Javier/0000-0002-4452-0855; Saez Lara, Maria Jose/0000-0001-7439-9817;
   Plaza-Diaz, Julio/0000-0002-5171-9408
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NR 67
TC 228
Z9 256
U1 5
U2 97
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD JUN
PY 2016
VL 17
IS 6
AR 928
DI 10.3390/ijms17060928
PG 15
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA DP9EK
UT WOS:000378799300141
PM 27304953
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Das, A
AF Das, Aniruddha
TI Psychosocial distress and inflammation: Which way does causality flow?
SO SOCIAL SCIENCE & MEDICINE
LA English
DT Article
DE Inflammation; Psychosocial distress; Older adults; NSHAP
ID C-REACTIVE PROTEIN; NATIONAL SOCIAL-LIFE; MARGINAL STRUCTURAL MODELS;
   CORONARY-HEART-DISEASE; CARDIOVASCULAR-DISEASE; DEPRESSIVE SYMPTOMS;
   METABOLIC SYNDROME; CHRONIC STRESS; OLDER-ADULTS; HEALTH
AB Objectives: This study queried causal direction in linkages of inflammation with psychosocial distress.
   Methods: Data were from the 2005-2006 and 2010-2011 waves of the U.S. National Social Life, Health, and Aging Project. Inflammation was indicated by C-reactive protein, and distress by depression, anxiety, as well as stress. Autoregressive cross-lagged panel models were used to examine causal direction.
   Results: Rather than being an outcome of psychosocial distress, inflammation was a predictor of it. Linkages were gender differentiated, with inflammation seeming to induce depression among men but stress among women.
   Discussion: Contrary to previous literature, inflammation may not be a mechanism through which psychosocial distress gets "under the skin" to cause cardiovascular and metabolic issues. Rather, it may be a node through which social pathologies and life events influence both mental health and physiological problems. (C) 2016 Elsevier Ltd. All rights reserved.
C1 [Das, Aniruddha] McGill Univ, Dept Sociol, Room 712,Leacock Bldg,855 Sherbrooke St West, Montreal, PQ H3A 2T7, Canada.
C3 McGill University
RP Das, A (corresponding author), McGill Univ, Dept Sociol, Room 712,Leacock Bldg,855 Sherbrooke St West, Montreal, PQ H3A 2T7, Canada.
EM aniruddha.das@mcgill.ca
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NR 79
TC 39
Z9 44
U1 0
U2 23
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0277-9536
EI 1873-5347
J9 SOC SCI MED
JI Soc. Sci. Med.
PD DEC
PY 2016
VL 170
BP 1
EP 8
DI 10.1016/j.socscimed.2016.10.001
PG 8
WC Public, Environmental & Occupational Health; Social Sciences, Biomedical
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; Biomedical Social Sciences
GA ED8FZ
UT WOS:000389108700001
PM 27728857
DA 2025-06-11
ER

PT J
AU Champaneri, S
   Wand, GS
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   Casagrande, SS
   Golden, SH
AF Champaneri, Shivam
   Wand, Gary S.
   Malhotra, Saurabh S.
   Casagrande, Sarah S.
   Golden, Sherita Hill
TI Biological Basis of Depression in Adults with Diabetes
SO CURRENT DIABETES REPORTS
LA English
DT Article
DE Diabetes; Depression; Type 2 diabetes; Obesity; Metabolic syndrome;
   Hypothalamic-pituitary-adrenal (HPA) axis; Sympathetic nervous system;
   Cortisol; Catecholamines; Inflammation; Inflammatory markers; Cytokines;
   Insulin resistance; Cortisol awakening response; Diurnal cortisol;
   Awakening cortisol; Visceral fat; Heart rate variability;
   Adipocytokines; C-reactive protein (CRP); Interleukin-6 (IL-6)
ID CORTISOL AWAKENING RESPONSE; POST-PUBERTAL ADOLESCENTS; AUTONOMIC
   NERVOUS-SYSTEM; HEART-RATE-VARIABILITY; ADRENAL-GLAND VOLUME; METABOLIC
   SYNDROME; INFLAMMATORY BIOMARKERS; PSYCHOLOGICAL STRESS; INSULIN
   SENSITIVITY; OXIDATIVE STRESS
AB Diabetes and depression are common comorbid conditions. Although certain health behaviors and risk factors partially explain the association of depression and diabetes, other potential mechanisms have yet to be elucidated. Certain neuroendocrine alterations such as activation of the hypothalamic-pituitary-adrenal (HPA) axis and sympathetic nervous system (SNS) may contribute to the association. Additionally, presence of a proinflammatory state shown in recent literature in both diabetes and depression may contribute to this as well. The objectives of this review are to summarize and review the recent evidence showing alterations of these three biological systems-HPA axis, SNS, and inflammatory cascade-in depression, diabetes, and diabetes-related risk factors.
C1 [Golden, Sherita Hill] Johns Hopkins Univ, Div Endocrinol & Metab, Sch Med, Baltimore, MD 21205 USA.
   [Champaneri, Shivam; Wand, Gary S.; Casagrande, Sarah S.] Johns Hopkins Univ, Dept Med, Sch Med, Baltimore, MD 21205 USA.
   [Wand, Gary S.] Johns Hopkins Univ, Dept Psychiat, Sch Med, Baltimore, MD 21205 USA.
   [Malhotra, Saurabh S.] Indiana Univ, Dept Med, Indianapolis, IN USA.
C3 Johns Hopkins University; Johns Hopkins University; Johns Hopkins
   University; Indiana University System; Indiana University Indianapolis
RP Golden, SH (corresponding author), Johns Hopkins Univ, Div Endocrinol & Metab, Sch Med, 2024 E Monument St,Suite 2-616, Baltimore, MD 21205 USA.
EM sahill@jhmi.edu
FU National Institute of Diabetes, Digestive, and Kidney Diseases [5K23
   DK071565]; Ruth L. Kirschstein National Research Service Award [T32];
   Johns Hopkins University School of Medicine [M01-RR00052]; National
   Center for Research Resources/National Institutes of Health; National
   Institutes of Diabetes, Digestive, and Kidney Diseases [P60 DK079637]
FX Dr. Golden was supported by a Patient-Oriented Mentored Scientist Award
   through the National Institute of Diabetes, Digestive, and Kidney
   Diseases (5K23 DK071565). Dr. Champaneri was supported by a training
   grant (T32 Ruth L. Kirschstein National Research Service Award). This
   research was supported by the Johns Hopkins University School of
   Medicine General Clinical Research Grant grant number M01-RR00052, from
   the National Center for Research Resources/National Institutes of Health
   and the Johns Hopkins Prevention and Control Core of the Diabetes
   Research and Training Center from the National Institutes of Diabetes,
   Digestive, and Kidney Diseases grant number P60 DK079637. We thank Dr.
   Mark Punyanitya for performing visceral fat measurements and our
   research coordinator, Ms. Bennette Drummond-Watts, for her excellent
   recruitment and study coordination skills.
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NR 63
TC 140
Z9 160
U1 1
U2 31
PU CURRENT MEDICINE GROUP
PI PHILADELPHIA
PA 400 MARKET STREET, STE 700, PHILADELPHIA, PA 19106 USA
SN 1534-4827
EI 1539-0829
J9 CURR DIABETES REP
JI Curr. Diabetes Rep.
PD DEC
PY 2010
VL 10
IS 6
BP 396
EP 405
DI 10.1007/s11892-010-0148-9
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 736LC
UT WOS:000288495200001
PM 20878274
DA 2025-06-11
ER

PT J
AU Barbosa, CD
   das Merces, MC
   Santana, AIC
   Silva, DDE
   Pimentel, RFW
   Coelho, JMF
   Almeida, AAE
   Damasceno, KSM
   Rossi, TRA
   D'Oliveira, A Jr
AF Barbosa, Caroline da Silva
   das Merces, Magno Conceicao
   Costa Santana, Amalia Ivine
   de Souza e Silva, Douglas
   Weyll Pimentel, Rodrigo Fernandes
   Freitas Coelho, Julita Maria
   Almeida e Almeida, Alex
   Meneses Damasceno, Kairo Silvestre
   Aranha Rossi, Thais Regis
   D'Oliveira Junior, Argemiro
TI Anxiety and dyslipidemia among primary health care professionals: A
   Cross-sectional study
SO WORK-A JOURNAL OF PREVENTION ASSESSMENT & REHABILITATION
LA English
DT Article
DE Anxiety; dyslipidemia; primary health care; epidemiology; mental health
ID METABOLIC SYNDROME; STRESS; WORK; DEPRESSION; PREVALENCE; INVENTORY;
   SYMPTOMS; BURNOUT
AB BACKGROUND: Cross-sectional studies point out important evidence between anxiety and dyslipdemic disorders in health workers.
   OBJECTIVE: Our main objective was to estimate the association between anxiety and dyslipidemia in Primary Health Care (PHC) nursing professionals in Feira de Santana, Bahia, Brazil.
   METHODS: A confirmatory cross-sectional study involving 376 PHC nursing professionals. Data collection occurred through the application of a questionnaire containing sociodemographic, labor and lifestyle issues, and the Beck Inventory for anxiety; to evaluate the lipid profile, the HDL-c, LDL-c, and triglycerides markers were evaluated. Descriptive, bivariate analysis and Logistic Regression were performed.
   RESULTS: The estimated prevalence of moderate/severe anxiety corresponded to 26.1% and dyslipidemia was 54.8%, with a statistically significant association between both of variables stratified by physical activity (PR = 2.69; 95%CI = 1.87-3.85) and (PR = 1.87; 95%CI = 1.53-2.28).
   CONCLUSIONS: There is a positive association between anxiety and dyslipidemia in Primary Health Care nursing professionals.
C1 [Barbosa, Caroline da Silva; das Merces, Magno Conceicao; Costa Santana, Amalia Ivine; de Souza e Silva, Douglas; D'Oliveira Junior, Argemiro] Fed Univ Bahia UFBA, Sch Med, Hlth Sci Postgrad Program, Salvador, BA, Brazil.
   [das Merces, Magno Conceicao; Weyll Pimentel, Rodrigo Fernandes; Meneses Damasceno, Kairo Silvestre; Aranha Rossi, Thais Regis] State Univ Bahia UNEB, Dept Life Sci, Salvador, BA, Brazil.
   [Freitas Coelho, Julita Maria] Fed Inst Educ Bahia IFBA, Simoes Filho, BA, Brazil.
   [Almeida e Almeida, Alex] Transcend Clin TC, Salvador, BA, Brazil.
C3 Universidade Federal da Bahia; Universidade do Estado Bahia
RP das Merces, MC (corresponding author), Univ Estado Bahia UNEB, Dept Ciencias Vida DCV, Rua Silveira Martins 2555, BR-41150000 Cabula Salvador, BA, Brazil.
EM mmerces@uneb.br
RI Merces, Magno/S-6649-2017
OI Silvestre Meneses Damasceno, Kairo/0000-0002-2444-4496
FU NATIONAL COUNCIL FOR SCIENTIFIC AND TECHNOLOGICAL DEVELOPMENT (CNPq),
   Brazil [408390/2016-6]
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: This work
   was supported by the NATIONAL COUNCIL FOR SCIENTIFIC AND TECHNOLOGICAL
   DEVELOPMENT (CNPq), Brazil [Universal Call Notice protocol
   #408390/2016-6].
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NR 47
TC 5
Z9 5
U1 1
U2 5
PU IOS PRESS
PI AMSTERDAM
PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS
SN 1051-9815
EI 1875-9270
J9 WORK
JI Work
PY 2022
VL 71
IS 3
BP 739
EP 748
DI 10.3233/WOR-205095
PG 10
WC Public, Environmental & Occupational Health
WE Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA 0W7BA
UT WOS:000789177200023
PM 35253673
DA 2025-06-11
ER

PT J
AU Takeuchi, T
   Nakao, M
   Nomura, K
   Inoue, M
   Tsurugano, S
   Shinozaki, Y
   Yano, E
AF Takeuchi, Takeaki
   Nakao, Mutsuhiro
   Nomura, Kyoko
   Inoue, Mariko
   Tsurugano, Shinobu
   Shinozaki, Yasuko
   Yano, Eiji
TI Association of the metabolic syndrome with depression and anxiety in
   Japanese men: A 1-year cohort study
SO DIABETES-METABOLISM RESEARCH AND REVIEWS
LA English
DT Article
DE anxiety; depression; employees; Japan; metabolic syndrome
ID MAJOR DEPRESSION; YOUNG-ADULTS; SYMPTOMS; EXERCISE; VALIDITY; OBESITY;
   STRESS; HEALTH
AB Background Recent studies on the association between the metabolic syndrome (MetS) and depression have reported conflicting findings. This 1-year cohort study aims to evaluate the association of MetS with the development of both depression and anxiety.
   Methods The cohort comprised 956 Japanese male employees of an enterprise (mean age, 42.7 years; SD, 10.2 years). MetS was diagnosed according to the International Diabetes Federation criteria. The psychological conditions of depression and anxiety were assessed in 2 successive years by using the profile of mood states (POMS) questionnaire and by conducting clinical interviews as per the fourth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV). We evaluated the temporal and dose-response relationships between MetS and the development of depression and anxiety, controlling for potential confounding factors like age and lifestyle-related factors.
   Results We identified a positive relationship between MetS at baseline and new-onset depression in the subsequent year (OR 2.14, 95% Cl 1.10-4.17). Of the five MetS components examined only waist circumference, was significantly related to new-onset depression (OR 2.08, 1.23-3.50). Trend analysis revealed a significant positive trend of association between the number of MetS components identified and new-onset depression (P-trend < 0.01), but not between Mets and new-onset anxiety.
   Conclusions Our results suggest that MetS is a predictive factor for the development of depression, and that waist circumference largely contributes to the association between MetS and depression. Copyright (C) 2009 John Wiley & Sons, Ltd.
C1 [Takeuchi, Takeaki] Teikyo Univ, Sch Med, Dept Hyg & Publ Hlth, Itabashi Ku, Tokyo 1738605, Japan.
   [Takeuchi, Takeaki; Nakao, Mutsuhiro; Nomura, Kyoko] Teikyo Univ Hosp, Div Psychosomat Med, Tokyo, Japan.
C3 Teikyo University; Teikyo University
RP Takeuchi, T (corresponding author), Teikyo Univ, Sch Med, Dept Hyg & Publ Hlth, Itabashi Ku, 2-11-1 Kaga, Tokyo 1738605, Japan.
EM takeakij@post.harvard.edu
FU Japanese Ministry of Education, Culture, Sports, Science, and Technology
   [20590659]; Grants-in-Aid for Scientific Research [20590659] Funding
   Source: KAKEN
FX This study was supported by a Grant-in-Aid for Scientists No. 20590659
   (Kiban, 2008-2010) from the Japanese Ministry of Education, Culture,
   Sports, Science, and Technology.
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   Yasuda Norihisa, 2008, Masui, V57, P764
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   Zimmerman M, 2006, COMPR PSYCHIAT, V47, P185, DOI 10.1016/j.comppsych.2005.07.004
NR 30
TC 61
Z9 68
U1 0
U2 8
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1520-7552
EI 1520-7560
J9 DIABETES-METAB RES
JI Diabetes-Metab. Res. Rev.
PD NOV
PY 2009
VL 25
IS 8
BP 762
EP 767
DI 10.1002/dmrr.1041
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism
GA 522RP
UT WOS:000272016300010
PM 19839027
DA 2025-06-11
ER

PT J
AU Matthew, A
   Elterman, D
AF Matthew, Andrew
   Elterman, Dean
TI Men's mental health: Connection to urologic health
SO CUAJ-CANADIAN UROLOGICAL ASSOCIATION JOURNAL
LA English
DT Review
ID GENDER-DIFFERENCES; HELP-SEEKING; DEPRESSION; BARRIERS; PREVALENCE;
   ANXIETY; CANCER
AB Historically, the specialty of urology has focused on single-system diseases. In recent years, however, there has been increasing recognition of the interconnectivity between the various systems, such as cardiovascular disease, metabolic syndrome, erectile dysfunction and prostate cancer. This constellation of disease/syndrome and dysfunction may place urologists at the centre of men's overall health concerns. As urologists considering taking on a leadership role in men's health, they should also consider their potential in helping men suffering from the significant burden of a mental health disorder. Urologists may have a unique opportunity to identify mental health issues in their male patients, influence healthy behaviour change, and successfully refer men, who might otherwise not seek help, to appropriate medical/psychological care.
C1 [Matthew, Andrew] Princess Margaret Canc Ctr, Dept Surg Oncol, Div Urol, Toronto, ON, Canada.
   [Elterman, Dean] Toronto Western Hosp, Div Urol, Toronto, ON M5T 2S8, Canada.
C3 University of Toronto; University Health Network Toronto; Princess
   Margaret Cancer Centre; University of Toronto; University Health Network
   Toronto
RP Elterman, D (corresponding author), Toronto Western Hosp, 399 Bathurst St, Toronto, ON M5T 2S8, Canada.
EM deanelterman@gmail.com
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NR 27
TC 8
Z9 8
U1 0
U2 3
PU CANADIAN UROLOGICAL ASSOCIATION
PI DORVAL
PA 185 DORVAL AVENUE, STE 401, DORVAL, QC H9S 5J9, CANADA
SN 1911-6470
EI 1920-1214
J9 CUAJ-CAN UROL ASSOC
JI CUAJ-Can. Urol. Assoc. J.
PD AUG
PY 2014
VL 8
IS 7-8
SU 5
BP S153
EP S155
DI 10.5489/cuaj.2312
PG 3
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA AQ0BX
UT WOS:000342447700006
PM 25243041
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Gu, CY
   Zhou, W
   Wang, W
   Xiang, H
   Xu, HY
   Liang, LN
   Sui, H
   Zhan, LB
   Lu, XG
AF Gu, Chunyan
   Zhou, Wen
   Wang, Wang
   Xiang, Hong
   Xu, Huiying
   Liang, Lina
   Sui, Hua
   Zhan, Libin
   Lu, Xiaoguang
TI ZiBuPiYin recipe improves cognitive decline by regulating gut microbiota
   in Zucker diabetic fatty rats
SO ONCOTARGET
LA English
DT Article
DE ZiBuPiYin recipe; diabetes; psychological-stress; cognitive decline; gut
   microbiota; Pathology Section
ID INSULIN-RESISTANCE; METABOLIC SYNDROME; LEPTIN RECEPTOR; STRESS;
   OBESITY; INFLAMMATION; DEFICITS; IMPAIRMENTS; BEHAVIORS; PATHWAYS
AB Numerous researches supported that microbiota can influence behavior and modulate cognitive function through "microbiota-gut-brain" axis. Our previous study has demonstrated that ZiBuPiYin recipe (ZBPYR) possesses excellent pharmacological effects against diabetes-associated cognitive decline. To elucidate the role of ZBPYR in regulating the balance of gut microbiota to improve psychological-stress-induced diabetes-associated cognitive decline (PSDACD), we compared blood glucose, behavioral and cognitive functions and diversity of the bacterial community among experimental groups. The Zucker diabetic fatty (ZDF) rats with PSDACD exhibited behavioral and cognitive anomalies showing as increased anxiety- and depression-like behaviors and decreased learning and memory abilities. High-throughput sequencing of the bacterial 16S rRNA gene revealed that Roseburia and Coprococcus were decreased in ZDF rats with PSDACD compared with control group. Notably, these changes were reversed by ZBPYR treatment. Our findings indicate that ZBPYR might prevent PSDACD by maintaining the compositions of gut microbiota, which could be developed as a new therapy for T2D with PSDACD.
C1 [Gu, Chunyan; Wang, Wang] Nanjing Univ Chinese Med, Sch Med & Life Sci, Nanjing, Jiangsu, Peoples R China.
   [Zhou, Wen; Xu, Huiying; Zhan, Libin] Nanjing Univ Chinese Med, Basic Med Coll, Nanjing, Jiangsu, Peoples R China.
   [Xiang, Hong; Zhan, Libin] Dalian Med Univ, Affiliated Hosp 2, Dalian, Liaoning, Peoples R China.
   [Liang, Lina; Sui, Hua] Dalian Med Univ, Inst Integrat Med, Dalian, Liaoning, Peoples R China.
   [Lu, Xiaoguang] Dalian Univ, Zhongshan Hosp, Dept Emergency Med, Dalian, Liaoning, Peoples R China.
C3 Nanjing University of Chinese Medicine; Nanjing University of Chinese
   Medicine; Dalian Medical University; Dalian Medical University; Dalian
   University
RP Zhan, LB (corresponding author), Nanjing Univ Chinese Med, Basic Med Coll, Nanjing, Jiangsu, Peoples R China.; Zhan, LB (corresponding author), Dalian Med Univ, Affiliated Hosp 2, Dalian, Liaoning, Peoples R China.; Lu, XG (corresponding author), Dalian Univ, Zhongshan Hosp, Dept Emergency Med, Dalian, Liaoning, Peoples R China.
EM zlbnj@njucm.edu.cn; dllxg100@126.com
FU National Nature Science Foundation of China [81230084]
FX This study was supported by grants from the National Nature Science
   Foundation of China (No. 81230084).
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NR 60
TC 23
Z9 27
U1 3
U2 32
PU IMPACT JOURNALS LLC
PI ORCHARD PARK
PA 6666 E QUAKER ST, STE 1, ORCHARD PARK, NY 14127 USA
EI 1949-2553
J9 ONCOTARGET
JI Oncotarget
PD APR 25
PY 2017
VL 8
IS 17
BP 27693
EP 27703
DI 10.18632/oncotarget.14611
PG 11
WC Oncology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Cell Biology
GA ET1SU
UT WOS:000400050000006
PM 28099913
OA Green Submitted, gold, Green Published
DA 2025-06-11
ER

PT J
AU Lin, KP
   Liang, TL
   Liao, IC
   Tsay, SL
AF Lin, Kuan Pin
   Liang, Tien Li
   Liao, I. Chen
   Tsay, Shiow Luan
TI Associations Among Depression, Obesity, and Metabolic Syndrome in Young
   Adult Females
SO BIOLOGICAL RESEARCH FOR NURSING
LA English
DT Article
DE depression; obesity; metabolic syndrome; young adult females
ID INSULIN-RESISTANCE; MAJOR DEPRESSION; NATIONAL-HEALTH; VISCERAL FAT;
   ANXIETY; STRESS; INFLAMMATION; SYMPTOMS; WOMEN
AB Depression may be a risk factor for obesity or metabolic syndrome. The aims of this study were to determine the relationships among depression, obesity, and metabolic syndrome in young adult females as well as the role of depression in the components of metabolic syndrome. A cross-sectional study was conducted on 323 young adult females. Demographic characteristics, anthropometric measurements, and laboratory values were collected. The criteria of the Bureau of Health Promotion, Department of Health, Taiwan, were used to define metabolic syndrome. Depression was measured using the Center for Epidemiologic Studies Depression scale. The prevalence of depression in the sample was 17%, that of overweight and obesity was 17%, and that of metabolic syndrome was 6.8%. Depression showed significant associations with high body mass index (BMI), increased waist circumference and blood pressure (BP), and overweight and obesity (beta = 0.15, odds ratio [OR] = 1.17, 95% confidence interval [CI] = [1.11, 1.23], p <.001). No associations were observed between depression and metabolic syndrome (beta = -0.01, OR = 0.99, 95% CI = [0.92, 1.06], p = .69) or any of its individual components after adjustment for BMI and demographic variables. The findings show that depression was associated with increasing odds of overweight and obesity in young adult females and may also have increased the physiological risk associated with metabolic syndrome. Early detection of depression and obesity as part of metabolic syndrome is important in the health management of young adult females for decreasing the risks of cardiovascular disease and diabetes.
C1 [Lin, Kuan Pin; Liang, Tien Li; Liao, I. Chen] HungKuang Univ, Dept Nursing, Taichung, Taiwan.
   [Lin, Kuan Pin; Liang, Tien Li] Natl Taipei Univ Nursing & Hlth Sci, Sch Nursing, Taipei, Taiwan.
   [Liao, I. Chen] Taipei Med Univ, Coll Nursing, Taipei, Taiwan.
   [Tsay, Shiow Luan] Da Yeh Univ, Coll Nursing & Hlth, Dacun 51591, Changhua, Taiwan.
C3 Hungkuang University; National Taipei University of Nursing & Health
   Science (NTUNHS); Taipei Medical University; Da Yeh University
RP Tsay, SL (corresponding author), Da Yeh Univ, Coll Nursing & Hlth, 168 Univ Rd, Dacun 51591, Changhua, Taiwan.
EM sltsay0308@gmail.com
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NR 33
TC 19
Z9 22
U1 3
U2 30
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1099-8004
EI 1552-4175
J9 BIOL RES NURS
JI Biol. Res. Nurs.
PD JUL
PY 2014
VL 16
IS 3
BP 327
EP 334
DI 10.1177/1099800413500138
PG 8
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA AP9HN
UT WOS:000342389700011
PM 24057221
DA 2025-06-11
ER

PT J
AU Kwok, ZCM
   Tam, HL
   Zee, BCY
   Lo, SWS
   Tang, FWK
   Tao, A
   Chan, HYL
AF Kwok, Zoe Ching-man
   Tam, Hon-lon
   Zee, Benny Chung-ying
   Lo, Sally Wai-sze
   Tang, Fiona Wing-ki
   Tao, An
   Chan, Helen Yue-lai
TI A protection motivation theory-guided telehealth coaching program for
   middle-aged adults with cardiometabolic risk: A feasibility trial
SO BMC PUBLIC HEALTH
LA English
DT Article
DE Cardiometabolic disease; Feasibility trial; Health coaching; Middle-aged
   adults; Primary prevention
ID SLEEP QUALITY INDEX; CHINESE VERSION; HEALTH; INTERVENTION; DEPRESSION;
   SERVICES; BEHAVIOR
AB BackgroundHealth coaching to address the escalated cardiometabolic risk in middle-aged adults in primary health care is underexplored. This study aimed to examine the feasibility and acceptability of a protection motivation theory-guided telehealth coaching program among middle-aged adults with cardiometabolic risks.MethodsThis was a pretest-posttest study. The three-month intervention included four nurse-facilitated telehealth sessions tailored to individual cardiometabolic risks.ResultsThirty participants were recruited through social media and a community center. The eligibility and enrollment rates were 16.1% and 78.9%, respectively. Attrition at six months after enrollment was 33.3%, and intervention attendance was 82.5%. Most of the participants (76.7%) were satisfied with the program. Significant improvements were noted in the INTERHEART score for cardiometabolic risks, self-efficacy, anxiety, stress, and central obesity but not in health-promoting behaviors, depression, sleep quality, physical activity level, and physiological outcomes at six-month post-enrolment.ConclusionA theory-based telehealth coaching was feasible and well-accepted among middle-aged adults, with potential in reducing cardiometabolic risks among middle-aged adults in primary care. This study revealed significant improvement in cardiometabolic risk, self-efficacy, anxiety, stress, and central obesity but changes for health-promoting behaviors, depression, sleep quality, physical activity level, and physiological outcomes were not noted. Progression to a definitive trial was supported with implication for future trials, including lowering the threshold of cardiometabolic risk to improve subject recruitment, change of assessment sessions to promote adherence to fasting instruction, and use of digital recording to facilitate health coaching process.Trial registration: This trial was retrospectively registered on 05/07/2022 at ClinicalTrials.gov (identifier: NCT05444140).
C1 [Kwok, Zoe Ching-man; Tam, Hon-lon; Tang, Fiona Wing-ki; Tao, An; Chan, Helen Yue-lai] Chinese Univ Hong Kong, Fac Med, Nethersole Sch Nursing, Shatin, Hong Kong, Peoples R China.
   [Zee, Benny Chung-ying] Chinese Univ Hong Kong, Fac Med, Jockey Club Sch Publ Hlth & Primary Care, Hong Kong, Peoples R China.
   [Lo, Sally Wai-sze] Univ Tasmania, Sch Nursing, Hobart, Australia.
C3 Chinese University of Hong Kong; Chinese University of Hong Kong;
   University of Tasmania
RP Chan, HYL (corresponding author), Chinese Univ Hong Kong, Fac Med, Nethersole Sch Nursing, Shatin, Hong Kong, Peoples R China.
EM helencyl@cuhk.edu.hk
RI Kwok, Ching Man Zoe/IXX-1928-2023; Tam, Hon Lon/W-1371-2019; Tang,
   Fiona/K-4575-2015; Lo, Sally Wai-Sze/N-7512-2015
OI Lo, Sally Wai-Sze/0000-0002-7883-7295
FU Knowledge Transfer Project Fund, The Chinese University of Hong Kong
FX We would also like to thank Wofoo Wellness Hub and participants for
   their support to the study, and Ms. Shirley Tai and Mr John Lau for the
   administrative support provided in this study.
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NR 59
TC 0
Z9 0
U1 1
U2 1
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2458
J9 BMC PUBLIC HEALTH
JI BMC Public Health
PD MAR 24
PY 2025
VL 25
IS 1
AR 1120
DI 10.1186/s12889-025-22238-w
PG 12
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA 0MW7V
UT WOS:001451155800004
PM 40128717
OA gold
DA 2025-06-11
ER

PT J
AU Marzoog, BA
AF Marzoog, Basheer Abdullah
TI Recent advances in molecular biology of metabolic syndrome
   pathophysiology: endothelial dysfunction as a potential therapeutic
   target
SO JOURNAL OF DIABETES AND METABOLIC DISORDERS
LA English
DT Review
DE Pathogenesis; Insulin resistance; Endothelial cells; COVID-19; Metabolic
   syndrome; Oxidative stress; Lipid peroxidation; Nitric oxide
ID DISEASE; INFLAMMATION; HEMOSTASIS; MECHANISMS; MARKERS; STRESS
AB Current advances in molecular pathobiology of endotheliocytes dysfunctions are promising in finding the pathogenetic links to the emergence of insulin resistance syndrome. Physiologically, human organism homeostasis is strictly controlled to maintain metabolic processes at the acquainted level. Many factors are involved in maintaining these physiological processes in the organism and any deviation is undoubtedly accompanied by specific pathologies related to the affected process. Fortunately, the body's defense system can solve and compensate for the impaired function through its multi-level defense mechanisms. The endothelium is essential in maintaining this homeostasis through its ability to modulate the metabolic processes of the organism. Pathological activity or impairment of physiological endothelium function seems directly correlated to the emergence of metabolic syndrome. The most accepted hypothesis is that endothelium distribution is due to endoplasmic reticulum stress and unfolded protein response development, which includes inhibition of long non-coding RNAs expression, cytokines disbalance, Apelin dysregulation, glycocalyx degradation, and specific microparticles. Clinically, the enhancement or restoration of normal endothelial cells can be a target for novel therapeutic strategies since the distribution of its physiological activity impairs homeostasis and results in the progression of metabolic syndrome, and induction of its physiological activity can ameliorate insulin resistance syndrome. Novel insights on the molecular mechanisms of endothelial cell dysfunction are concisely represented in this paper to enhance the present therapeutic tactics and advance the research forward to find new therapeutic targets.
C1 [Marzoog, Basheer Abdullah] Mordovia State Univ, Natl Res, Bolshevitskaya St 68, Saransk, Russia.
   [Marzoog, Basheer Abdullah] Bolshevitskaya St 31, Saransk 430005, Russia.
C3 Mordovian State University
RP Marzoog, BA (corresponding author), Mordovia State Univ, Natl Res, Bolshevitskaya St 68, Saransk, Russia.; Marzoog, BA (corresponding author), Bolshevitskaya St 31, Saransk 430005, Russia.
EM marzug@mail.ru
RI Marzoog, Basheer Abdullah/AAD-6284-2021
OI Marzoog, Basheer Abdullah/0000-0001-5507-2413
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NR 107
TC 11
Z9 17
U1 1
U2 16
PU SPRINGER INT PUBL AG
PI CHAM
PA GEWERBESTRASSE 11, CHAM, CH-6330, SWITZERLAND
EI 2251-6581
J9 J DIABETES METAB DIS
JI J. Diabetes Metab. Disord.
PD DEC
PY 2022
VL 21
IS 2
BP 1903
EP 1911
DI 10.1007/s40200-022-01088-y
EA AUG 2022
PG 9
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA 6G9RJ
UT WOS:000848005600002
PM 36065330
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Daneshzad, E
   Mansordehghan, M
   Larijani, B
   Heshmati, J
   Rouzitalab, T
   Pizarro, AB
   Azadbakht, L
AF Daneshzad, Elnaz
   Mansordehghan, Maryam
   Larijani, Bagher
   Heshmati, Javad
   Rouzitalab, Tohid
   Beatriz Pizarro, Ana
   Azadbakht, Leila
TI Diet quality indices are associated with sleep and mental health status
   among diabetic women: a cross-sectional study
SO EATING AND WEIGHT DISORDERS-STUDIES ON ANOREXIA BULIMIA AND OBESITY
LA English
DT Article
DE Diet quality index; Healthy eating index; Sleep; Depression; Anxiety;
   Diabetic patients
ID EATING INDEX; METABOLIC SYNDROME; DEPRESSION; RISK; DISEASE; PATTERNS;
   DURATION; PREVALENCE; GUIDELINES; DISORDERS
AB Objective Diabetes is a common chronic disease with many complications. Controlling these complexities may enhance the quality of life. This study was conducted to investigate the association between diet quality indices and sleep, stress, anxiety, and depression among diabetic women. Design Cross-sectional study. Setting A validated and reliable food frequency questionnaire was filled to assess the dietary intake and adherence to the diet quality indices. Pittsburgh Sleep Quality Index and 21 items Depression, Anxiety, and Stress Scale were used to assess the sleep and mental disorders, respectively. Participants This study was conducted on 230 Tehrani women with type 2 diabetes. Results Patients who were in the top tertile of diet quality index consumed less fat, saturated mono-and poly-unsaturated fatty acids, and sodium (P < 0.05). Participants who were in top tertile of diet quality indices consumed more fruits, and vegetables. Patients in the highest tertile of diet quality index-international had less risk of depression (OR: 0.17; 95% CI: 0.07; 0.41), anxiety (OR: 0.36; 95% CI: 0.16; 0.80), stress (OR: 0.09; 95% CI: 0.04; 0.21), and poor sleep (OR: 0.12; 95% CI: 0.04; 0.36). Patients in the highest tertile of healthy eating index-international had less risk of depression (OR: 0.06; 95% CI: 0.02; 0.21), anxiety (OR: 0.10; 95% CI: 0.04; 0.26), stress (OR: 0.11; 95% CI: 0.05; 0.26), and poor sleep (OR: 0.08; 95% CI: 0.03; 0.20). Conclusion Patients with higher adherence to diet quality indices were likely less to have mental disorders or poor sleep.
C1 [Daneshzad, Elnaz] Alborz Univ Med Sci, Noncommunicable Dis Res Ctr, Karaj, Iran.
   [Daneshzad, Elnaz; Azadbakht, Leila] Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Community Nutr, Tehran, Iran.
   [Mansordehghan, Maryam] Islamic Azad Univ, Dept Exercise, Cent Tehran Branch, Physiol, Tehran, Iran.
   [Larijani, Bagher] Univ Tehran Med Sci, Endocrinol & Metab Res Ctr, Endocrinol & Metab Clin Sci Inst, Tehran, Iran.
   [Heshmati, Javad] Kermanshah Univ Med Sci, Songhor Healthcare Ctr, Kermanshah, Iran.
   [Rouzitalab, Tohid] Tabriz Univ Med Sci, Nutr Res Ctr, Sch Nutr & Food Sci, Dept Biochem & Diet Therapy, Tabriz, Iran.
   [Beatriz Pizarro, Ana] Fdn Valle Lili, Clin Res Ctr, Cali, Colombia.
   [Azadbakht, Leila] Univ Tehran Med Sci, Diabet Res Ctr, Endocrinol & Metab Clin Sci Inst, Tehran, Iran.
C3 Alborz University of Medical Sciences; Tehran University of Medical
   Sciences; Islamic Azad University; Tehran University of Medical
   Sciences; Kermanshah University of Medical Sciences; Tabriz University
   of Medical Science; Fundacion Valle del Lili; Tehran University of
   Medical Sciences
RP Azadbakht, L (corresponding author), Univ Tehran Med Sci, Sch Nutr Sci & Dietet, Dept Community Nutr, Tehran, Iran.; Azadbakht, L (corresponding author), Univ Tehran Med Sci, Diabet Res Ctr, Endocrinol & Metab Clin Sci Inst, Tehran, Iran.
EM azadbakhtleila@gmail.com
RI larijani, Bagher/ABE-3315-2020; heshmati, javad/H-6812-2019; Pizarro,
   Ana/AAC-8021-2022; Azadbakht, Leila/N-2801-2018; Daneshzad,
   Elnaz/O-3694-2018
OI Daneshzad, Elnaz/0000-0003-1400-8532; Larijani,
   Bagher/0000-0001-5386-7597; Pizarro, Ana Beatriz/0000-0003-4089-454X
FU Tehran University of Medical Sciences [34260]
FX This study is supported by the Tehran University of Medical Sciences
   (grant number: 34260).
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NR 49
TC 10
Z9 10
U1 0
U2 12
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1124-4909
EI 1590-1262
J9 EAT WEIGHT DISORD-ST
JI Eat. Weight Disord.-Stud. Anorex.
PD MAY
PY 2022
VL 27
IS 4
BP 1513
EP 1521
DI 10.1007/s40519-021-01294-2
EA SEP 2021
PG 9
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychiatry
GA 1A7JS
UT WOS:000692429800001
PM 34480747
DA 2025-06-11
ER

PT J
AU Caso, F
   Fatica, M
   Ferraioli, M
   Megna, M
   Potestio, L
   Ruggiero, A
   Tommasino, N
   Maione, F
   Scarpa, R
   Chimenti, MS
   Costa, L
AF Caso, Francesco
   Fatica, Mauro
   Ferraioli, Mario
   Megna, Matteo
   Potestio, Luca
   Ruggiero, Angelo
   Tommasino, Nello
   Maione, Francesco
   Scarpa, Raffaele
   Chimenti, Maria Sole
   Costa, Luisa
TI The role of bDMARDs in the prevention and treatment of
   inflammatory-related comorbidities in Psoriatic Arthritis
SO EXPERT OPINION ON BIOLOGICAL THERAPY
LA English
DT Review
DE Psoriatic arthritis; bDMARDs; comorbidities; obesity; metabolic
   syndrome; depression; osteoporosis; NASH
ID NECROSIS-FACTOR-ALPHA; CARDIOVASCULAR RISK-FACTORS; DISEASE-ACTIVITY;
   RHEUMATOID-ARTHRITIS; METABOLIC SYNDROME; MANAGEMENT; EVENTS; DIAGNOSIS;
   IMPACT; DYSLIPIDEMIA
AB IntroductionPsoriatic arthritis (PsA) is an immune-inflammatory disease that affects both joints and entheses, and with diverse extra-articular manifestations (psoriasis, inflammatory bowel disease (IBD), and uveitis). A wide range of comorbid conditions, including cardiovascular diseases, obesity, metabolic syndrome (MetS), nonalcoholic fatty liver disease (NAFLD), mental health disorders (depression/anxiety), and osteoporosis are highly prevalent in course of PsA.Biological DMARDs (bDMARD), including TNF-inhibitors (TNFi), Interleukin (IL-17i) and IL-23i represent the cornerstone of the management of active disease. The use of these therapies obviously requires considering comorbidities presence, safety aspects and contraindications.IntroductionPsoriatic arthritis (PsA) is an immune-inflammatory disease that affects both joints and entheses, and with diverse extra-articular manifestations (psoriasis, inflammatory bowel disease (IBD), and uveitis). A wide range of comorbid conditions, including cardiovascular diseases, obesity, metabolic syndrome (MetS), nonalcoholic fatty liver disease (NAFLD), mental health disorders (depression/anxiety), and osteoporosis are highly prevalent in course of PsA.Biological DMARDs (bDMARD), including TNF-inhibitors (TNFi), Interleukin (IL-17i) and IL-23i represent the cornerstone of the management of active disease. The use of these therapies obviously requires considering comorbidities presence, safety aspects and contraindications.Areas coveredThe aim of this review is to describe the inflammatory mechanisms behind PsA comorbidities, and the role of bDMARDs in the prevention and treatment of these conditions in course of PsA.Expert opinionTailoring therapeutic strategies to the individual characteristics of each PsA patient can be an effective approach to manage comorbidities, maximizing the efficacy of bDMARDs, and reducing the incidence of AEs. Identifying targets within disease pathways can guide research into therapeutics that address both PsA and comorbidities simultaneously, but more studies are advocated for clarifying the potential prevention and management of bDMARDs used for PsA.
C1 [Caso, Francesco; Scarpa, Raffaele; Costa, Luisa] Univ Naples Federico II, Dept Clin Med & Surg, Via S Pansini 5, I-80131 Naples, Italy.
   [Fatica, Mauro; Ferraioli, Mario; Chimenti, Maria Sole] Univ Roma Tor Vergata, Dipartimento Med Sistemi, UOC Reumatol, Rome, Italy.
   [Megna, Matteo; Potestio, Luca; Ruggiero, Angelo; Tommasino, Nello] Univ Naples Federico II, Dept Clin Med & Surg, Sect Dermatol, Naples, Italy.
   [Maione, Francesco] Univ Naples Federico II, Sch Med & Surg, Dept Pharm, ImmunoPharmaLab, Naples, Italy.
C3 University of Naples Federico II; University of Rome Tor Vergata;
   University of Naples Federico II; University of Naples Federico II
RP Scarpa, R (corresponding author), Univ Naples Federico II, Dept Clin Med & Surg, Via S Pansini 5, I-80131 Naples, Italy.
EM rscarpa@unina.it
RI Megna, Matteo/AFH-8701-2022; Ruggiero, Angelo/ABF-8229-2021; Tommasino,
   Nello/LWI-2001-2024; Potestio, Luca/ABU-6123-2022; Ferraioli,
   Mario/MVT-9734-2025; Chimenti, Maria/AGH-6290-2022; Caso,
   Francesco/AAC-9809-2020
OI Caso, Francesco/0000-0002-8928-2520; Potestio, Luca/0000-0001-5940-0592
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   Zabotti A, 2023, ANN RHEUM DIS, V82, P1162, DOI 10.1136/ard-2023-224148
   Zhang ZL, 2023, FRONT IMMUNOL, V13, DOI 10.3389/fimmu.2022.1098725
   Zhao SS, 2020, CLIN RHEUMATOL, V39, P217, DOI 10.1007/s10067-019-04734-8
   Zhou X, 2022, CELL DEATH DIS, V13, DOI 10.1038/s41419-022-04523-3
   Zhou Y, 2022, DRUG SAFETY, V45, P951, DOI 10.1007/s40264-022-01210-2
   Zusman EZ, 2020, SEMIN ARTHRITIS RHEU, V50, P1481, DOI 10.1016/j.semarthrit.2020.02.001
NR 140
TC 1
Z9 1
U1 9
U2 10
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1471-2598
EI 1744-7682
J9 EXPERT OPIN BIOL TH
JI Expert Opin. Biol. Ther.
PD AUG 2
PY 2024
VL 24
IS 8
BP 719
EP 731
DI 10.1080/14712598.2024.2384090
EA JUL 2024
PG 13
WC Biotechnology & Applied Microbiology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Research & Experimental Medicine
GA D9P7R
UT WOS:001276945200001
PM 39037828
DA 2025-06-11
ER

PT J
AU Jakovljevic, M
   Babic, D
   Crncevic, Z
   Martinac, M
   Maslov, B
   Topic, R
AF Jakovljevic, Miro
   Babic, Dragan
   Crncevic, Zeljka
   Martinac, Marko
   Maslov, Boris
   Topic, Radmila
TI Metabolic syndrome and depression in war veterans with post-traumatic
   stress disorder
SO PSYCHIATRIA DANUBINA
LA English
DT Article; Proceedings Paper
CT 23rd Danube Symposium of Psychiatry
CY OCT 05-05, 2008
CL Mostar, BOSNIA & HERCEG
DE war veterans; combat posttraumatic stress disorder; depression
   comorbidity; metabolic syndrome
ID COMORBIDITY
AB Background. Post-traumatic stress disorder (PTSD), depression and metabolic syndromes are growing public health problems in post-war countries. Understanding the co-morbidity among PTSD, depression and metabolic syndrome has an important clinical and theoretical issue.
   Objective: To examine the relationship between combat-related PTSD, comorbid depression and metabolic syndrome as well as between severity of depression and metabolic syndrome.
   Method. Metabolic syndrome and co-morbid depression were investigated in 100 male war veterans with combat PTSD and in 79 males who needed medical attention in dispensary of family medicine.
   Results: Metabolic syndrome according NCEP: ATP III was found in 25% of war veterans with PTSD. Metabolic syndrome was identified more frequently in PTSD patients with co-morbid depression (47.8%) compared to those without depression (9.1%). PTSD with moderate and severe co-morbid depression was associated with higher rates of metabolic syndrome (78.6% and 90.9% respectively) in comparison with mild depression (26.2%).
   Conclusions: PTSD is frequently comorbid with depression, and when the two disorders co-occur, the risk for metabolic syndrome is increased. Treatment of war veterans with PTSD should address co-morbid depression and metabolic syndrome as well as the clinical features of PTSD.
C1 [Jakovljevic, Miro; Topic, Radmila] Univ Zagreb, Clin Hosp Ctr, Univ Psychiat Clin Rebro, Zagreb 10000, Croatia.
   [Jakovljevic, Miro; Babic, Dragan; Martinac, Marko; Maslov, Boris] Univ Mostar, Sch Med, Dept Psychiat, Mostar, Bosnia & Herceg.
   [Crncevic, Zeljka] Clin Hosp Ctr Rijeka, Univ Dept Endocrinol, Rijeka, Croatia.
C3 University of Zagreb; University of Mostar; University of Rijeka
RP Jakovljevic, M (corresponding author), Univ Zagreb, Clin Hosp Ctr, Univ Psychiat Clin Rebro, Kispaticeva 12, Zagreb 10000, Croatia.
EM predstojnik_psi@kbc-zagreb.hr
CR Babic D, 2007, PSYCHIAT DANUB, V19, P68
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NR 22
TC 38
Z9 39
U1 0
U2 7
PU MEDICINSKA NAKLADA
PI ZAGREB
PA VLASKA 69, HR-10000 ZAGREB, CROATIA
SN 0353-5053
EI 1849-0867
J9 PSYCHIAT DANUB
JI Psychiatr. Danub.
PD SEP
PY 2008
VL 20
IS 3
BP 406
EP 410
PG 5
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI); Conference Proceedings Citation Index - Social Science &amp; Humanities (CPCI-SSH); Conference Proceedings Citation Index - Science (CPCI-S)
SC Psychiatry
GA 356GP
UT WOS:000259767000022
PM 18827772
DA 2025-06-11
ER

PT J
AU Lederbogen, F
   Ulshöfer, E
   Peifer, A
   Fehlner, P
   Bilek, E
   Streit, F
   Deuschle, M
   Tost, H
   Meyer-Lindenberg, A
AF Lederbogen, Florian
   Ulshoefer, Elisabeth
   Peifer, Annika
   Fehlner, Phoebe
   Bilek, Edda
   Streit, Fabian
   Deuschle, Michael
   Tost, Heike
   Meyer-Lindenberg, Andreas
TI No association between cardiometabolic risk and neural reactivity to
   acute psychosocial stress
SO NEUROIMAGE-CLINICAL
LA English
DT Article
DE Psychosocial stress; fMRT; Cortico-limbic; Cardiovascular; Type 2
   diabetes; Framingham risk score
ID CORONARY-HEART-DISEASE; BLOOD-PRESSURE REACTIONS; ACUTE
   MYOCARDIAL-INFARCTION; ANTERIOR CINGULATE CORTEX; PSYCHOLOGICAL STRESS;
   MENTAL STRESS; SALIVARY CORTISOL; CARDIOVASCULAR-RESPONSES;
   SOCIAL-STATUS; BRAIN
AB Background: Exaggerated reactivity to acute psychosocial stress is associated with an increased risk of cardiovascular and metabolic disease. A dysfunction of the cortico-limbic network coordinating the peripheral adaptation to acute stress exposure may constitute a brain mechanism underlying this association. We opted to characterize the changes of this network associated with acute psychosocial stress exposure in individuals with low and high cardiometabolic risk (CMR).
   Methods: In 57 subjects without overt cardiac or cerebral disease, the Framingham risk score and presence/absence of type 2 diabetes or metabolic syndrome defined CMR. Psychosocial stress was induced during functional magnetic resonance imaging (fMRI) of brain activity by an established social threat paradigm. Measurements of heart rate, blood pressure and saliva cortisol quantified the peripheral stress reaction. Regression analyses for the anterior cingulate cortex, hippocampus, amygdala, insula and regulatory prefrontal regions evaluated the association of stress-associated brain activation and CMR.
   Results: Psychosocial stress exposure was associated with an increased activity of a brain network including anterior and posterior cingulate cortex, putamen, insula, parahippocampus and right hippocampus. Psychosocial stress-associated brain activation did neither covary with Framingham risk score nor differ between groups with low or high CMR.
   Conclusion: Exposure to acute psychosocial stress induces the activation of a well-defined cortico-limbic network. However, we did not find an association between CMR and this network's stress reactivity.
C1 [Lederbogen, Florian; Ulshoefer, Elisabeth; Peifer, Annika; Fehlner, Phoebe; Bilek, Edda; Streit, Fabian; Deuschle, Michael; Tost, Heike; Meyer-Lindenberg, Andreas] Heidelberg Univ, Med Fac Mannheim, Cent Inst Mental Hlth, J5, D-68159 Mannheim, Germany.
C3 Central Institute of Mental Health; Ruprecht Karls University Heidelberg
RP Lederbogen, F (corresponding author), Heidelberg Univ, Med Fac Mannheim, Cent Inst Mental Hlth, J5, D-68159 Mannheim, Germany.
EM florian.lederbogen@gmx.de; elisabeth.ulshoefer@zi-mannheim.de;
   phoebe.fehlner@zi-mannheim.de; edda.bilek@zi-mannheim.de;
   fabian.streit@zi-mannheim.de; michael.deuschle@zi-mannheim.de;
   heike.tost@zi-mannheim.de; a.meyer-lindenberg@zi-mannheim.de
RI Meyer-Lindenberg, Andreas/H-1076-2011; Tost, med./AAX-8305-2020; Streit,
   Fabian/IWV-1629-2023
OI Bilek, Edda/0000-0002-1532-7108; Streit, Fabian/0000-0003-1080-4339
FU German Research Foundation (Deutsche Forschungsgemeinschaft) [LE
   1126/6/1, ME 1591/7-1]
FX We gratefully acknowledge the support of Klaus Kusterer MD, Michael
   Enghofer MD, and Herbert Lutz MD, with enrolment of study subjects. We
   thank Dagmar Gass for technical assistance and Jennifer Bez MD for
   language revision. This work was supported by grants from the German
   Research Foundation (Deutsche Forschungsgemeinschaft) to FL (LE
   1126/6/1) and AML (ME 1591/7-1).
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NR 76
TC 7
Z9 8
U1 0
U2 7
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 2213-1582
J9 NEUROIMAGE-CLIN
JI NeuroImage-Clin.
PY 2018
VL 20
BP 1115
EP 1122
DI 10.1016/j.nicl.2018.10.018
PG 8
WC Neuroimaging
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology
GA HB1QI
UT WOS:000450799000119
PM 30380518
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Vargas, HO
   Nunes, SOV
   Barbosa, DS
   Vargas, MM
   Cestari, A
   Dodd, S
   Venugopal, K
   Maes, M
   Berk, M
AF Vargas, Heber Odebrecht
   Vargas Nunes, Sandra Odebrecht
   Barbosa, Decio Sabbatini
   Vargas, Mateus Mendonca
   Cestari, Ariane
   Dodd, Seetal
   Venugopal, Kamalesh
   Maes, Michael
   Berk, Michael
TI Castelli risk indexes 1 and 2 are higher in major depression but other
   characteristics of the metabolic syndrome are not specific to mood
   disorders
SO LIFE SCIENCES
LA English
DT Article
DE Metabolic syndrome; Bipolar disorder; Depression; Cholesterol; HDL;
   Inflammation; Oxidative stress; Antioxidants
ID C-REACTIVE PROTEIN; LIPID-LEVELS; BIPOLAR DISORDER; OXIDATIVE STRESS;
   WAIST CIRCUMFERENCE; PHYSICAL-ACTIVITY; MENTAL-HEALTH; DIET QUALITY;
   ASSOCIATION; INFLAMMATION
AB Aims: This study examined whether Castelli risk indexes 1 (total/high-density lipoprotein (HDL) cholesterol) and 2 (low density lipoprotein (LDL)/HDL cholesterol) and other shared metabolic disorders might underpin the pathophysiology of the metabolic syndrome, major depression or bipolar disorder. Main methods: This cross-sectional study examined 92 major depressed, 49 bipolar depressed and 201 normal controls in whom the Castelli risk indexes 1 and 2 and key characteristics of the metabolic syndrome, i.e. waist/hip circumference, body mass index (BMI), systolic/diastolic blood pressure, total cholesterol, low-density lipoprotein (LDL) and HDL cholesterol, triglycerides, insulin, glucose, hemoglobin Alc (HbA1c) and homocysteine were assessed. Key findings: Castelli risk indexes 1 and 2 were significantly higher in major depressed patients than in bipolar disorder patients and controls. There were no significant differences in waist or hip circumference, total and LDL cholesterol, triglycerides, plasma glucose, insulin, homocysteine and HbAl c between depression and bipolar patients and controls. Bipolar patients had a significantly higher BMI than major depressed patients and normal controls. Significance: Major depression is accompanied by increased Castelli risk indexes 1 and 2, which may be risk factors for cardiovascular disease. Other key characteristics of the metabolic syndrome, either metabolic biomarkers or central obesity, are not necessarily specific to major depression or bipolar disorder. (c) 2014 Elsevier Inc All rights reserved.
C1 [Vargas, Heber Odebrecht; Vargas Nunes, Sandra Odebrecht; Maes, Michael] Univ Estadual Londrina, Univ Hosp, Hlth Sci Ctr, Dept Psychiat, BR-86035380 Londrina, Parana, Brazil.
   [Vargas, Heber Odebrecht; Vargas Nunes, Sandra Odebrecht; Vargas, Mateus Mendonca; Cestari, Ariane] Univ Estadual Londrina, Univ Hosp, Ctr Approach & Treatment Smokers, BR-86051990 Londrina, Parana, Brazil.
   [Barbosa, Decio Sabbatini] Univ Estadual Londrina, Hlth Sci Ctr, Dept Clin Anal & Toxicol, Londrina, Parana, Brazil.
   [Dodd, Seetal; Venugopal, Kamalesh; Berk, Michael] Univ Melbourne, Dept Psychiat, Parkville, Vic 3052, Australia.
   [Dodd, Seetal; Maes, Michael; Berk, Michael] Deakin Univ, Sch Med, Geelong, Vic 3217, Australia.
   [Berk, Michael] Univ Melbourne, Ctr Youth Mental Hlth, Orygen Youth Hlth Res Ctr, Parkville, Vic 3052, Australia.
   [Dodd, Seetal; Venugopal, Kamalesh; Maes, Michael; Berk, Michael] Swanston Ctr, Barwon Hlth & Geelong Clin, Geelong, Vic 3220, Australia.
   [Maes, Michael] Chulalongkorn Univ, Dept Psychiat, Bangkok, Thailand.
   [Berk, Michael] Florey Inst Neurosci & Mental Hlth, Parkville, Vic, Australia.
C3 Universidade Estadual de Londrina; Universidade Estadual de Londrina;
   Universidade Estadual de Londrina; University of Melbourne; Deakin
   University; University of Melbourne; Orygen, The National Centre of
   Excellence in Youth Mental Health; Chulalongkorn University; Florey
   Institute of Neuroscience & Mental Health
RP Maes, M (corresponding author), Deakin Univ, Dept Psychiat, Geelong, Vic 3217, Australia.
EM dr.michaelmaes@hotmail.com
RI Berk, Michael/AGH-9427-2022; Maes, Michael/B-8546-2011; Barbosa,
   Décio/AAE-6351-2019; Venugopal, Kamalesh/NJT-2319-2025; Vargas,
   Mateus/JRZ-1132-2023; Berk, Michael/M-7891-2013
OI Dodd, Seetal/0000-0002-7918-4636; Berk, Michael/0000-0002-5554-6946;
   Venugopal, Kamalesh/0000-0002-5611-6489; Vargas,
   Mateus/0000-0003-1531-3256
FU Evaluation of Graduate Education (CAPES); Barwon Psychiatric Research
   Unit, Deakin University, Geelong, Australia; NHMRC Senior Principal
   Research Fellowship [1059660]
FX The authors would like to gratefully acknowledge the Health Sciences
   Postgraduate Program at the State University of Londrina, Brazil, the
   Ministry for Sciences and Technology of Brazil (CNPq), the Brazilian
   Federal Agency for Support and Evaluation of Graduate Education (CAPES)
   and the Barwon Psychiatric Research Unit, Deakin University, Geelong,
   Australia. MB is supported by a NHMRC Senior Principal Research
   Fellowship 1059660.
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NR 60
TC 49
Z9 52
U1 0
U2 23
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0024-3205
EI 1879-0631
J9 LIFE SCI
JI Life Sci.
PD APR 25
PY 2014
VL 102
IS 1
BP 65
EP 71
DI 10.1016/j.lfs.2014.02.033
PG 7
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA AG0GR
UT WOS:000335094400009
PM 24607777
DA 2025-06-11
ER

PT J
AU Lederman, O
   Suetani, S
   Stanton, R
   Chapman, J
   Korman, N
   Rosenbaum, S
   Ward, PB
   Siskind, D
AF Lederman, Oscar
   Suetani, Shuichi
   Stanton, Robert
   Chapman, Justin
   Korman, Nicole
   Rosenbaum, Simon
   Ward, Philip B.
   Siskind, Dan
TI Embedding exercise interventions as routine mental health care:
   implementation strategies in residential, inpatient and community
   settings
SO AUSTRALASIAN PSYCHIATRY
LA English
DT Article
DE physical activity; exercise; mental health; implementation; metabolic
   syndrome
ID PHYSICAL-ACTIVITY INTERVENTIONS; CARDIOMETABOLIC RISK-FACTORS;
   AFFECTIVE-DISORDERS; YOUNG-PEOPLE; PSYCHOSIS; BARRIERS; ILLNESS;
   PROGRAM; YOUTH
AB Objectives: Evaluation of physical activity (PA) programs among populations with severe mental illness (SMI) has predominately focused on efficacy and therapeutic benefits. There is now strong evidence to support the benefits of PA in people with SMI. What remains is a gap in the implementation of pragmatic and sustainable PA interventions in mental-health settings. The current paper provides examples of interventions that have been successfully implemented in Australian settings, identifies key components of successful PA interventions and outlines practical strategies that can assist with widespread implementation of PA interventions in mental-health settings.
   Conclusions: There is an emergence of PA interventions being imbedded within a variety of mental-health settings. These interventions vary in terms of mode and intensity of service delivery. Yet, all aim to increase PA and reduce sedentary behaviour. Adopting the identified strategies may help facilitate successful implementation and increase access to PA interventions for mental-health service users.
C1 [Lederman, Oscar] Univ New South Wales, Sch Med Sci, Sydney, NSW, Australia.
   [Lederman, Oscar] South Eastern Sydney Local Hlth Dist, Keeping Body Mind Program, Sydney, NSW, Australia.
   [Suetani, Shuichi; Siskind, Dan] Queensland Ctr Mental Hlth Res, Pk Ctr Mental Hlth, Wacol, Qld, Australia.
   [Suetani, Shuichi] Univ Queensland, Queensland Brain Inst, St Lucia, Qld, Australia.
   [Suetani, Shuichi; Korman, Nicole; Siskind, Dan] Univ Queensland, Sch Med, Brisbane, Qld, Australia.
   [Stanton, Robert] Cent Queensland Univ, Sch Hlth Med & Appl Sci, Rockhampton, Qld, Australia.
   [Chapman, Justin] Queensland Police Citizens Youth Welf Assoc, Brisbane, Qld, Australia.
   [Chapman, Justin] QIMR Berghofer Med Res Inst, Brisbane, Qld, Australia.
   [Korman, Nicole; Siskind, Dan] Metro South Addict & Mental Hlth Serv, Brisbane, Qld, Australia.
   [Rosenbaum, Simon; Ward, Philip B.] Univ New South Wales, Sch Psychiat, Sydney, NSW, Australia.
   [Rosenbaum, Simon] Univ New South Wales, Black Dog Inst, Prince Wales Hosp, Hosp Rd, Randwick, NSW, Australia.
   [Ward, Philip B.] South Western Sydney Local Hlth Dist, Schizophrenia Res Unit, Liverpool, NSW, Australia.
   [Ward, Philip B.] Ingham Inst Appl Med Res, Liverpool, NSW, Australia.
C3 University of New South Wales Sydney; South Eastern Sydney Local Health
   District; Queensland Centre for Mental Health Research; University of
   Queensland; University of Queensland; Central Queensland University;
   QIMR Berghofer Medical Research Institute; University of New South Wales
   Sydney; University of New South Wales Sydney; Prince of Wales Hospital
   (POWH); Black Dog Institute; South Western Sydney Local Health District;
   Ingham Institute for Applied Medical Research
RP Lederman, O (corresponding author), Univ New South Wales, Sch Med Sci, 26 Llandalff St, Bondi Jct, NSW 2022, Australia.
EM Oscar.Lederman@health.nsw.gov.au
RI Chapman, Justin/HLP-9248-2023; Stanton, Rob/AAJ-5157-2020; Rosenbaum,
   Simon/Y-3241-2019; Chapman, Justin/C-4631-2014; Siskind,
   Dan/A-9812-2014; Ward, Philip/JCE-6293-2023
OI Chapman, Justin/0000-0002-2958-2783; Lederman,
   Oscar/0000-0002-0321-5723; Rosenbaum, Simon/0000-0002-8984-4941;
   Siskind, Dan/0000-0002-2072-9216; Suetani, Shuichi/0000-0002-2487-5691;
   Ward, Philip/0000-0002-5779-7722
FU North Brisbane Partners in Recovery, which is an initiative of the
   Australian Government
FX The Healthy Bodies, Healthy Minds project has been made possible through
   a grant from North Brisbane Partners in Recovery, which is an initiative
   of the Australian Government.
CR Bartels SJ, 2015, AM J PSYCHIAT, V172, P9, DOI 10.1176/appi.ajp.2014.14101246
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NR 31
TC 61
Z9 69
U1 1
U2 9
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 1039-8562
EI 1440-1665
J9 AUSTRALAS PSYCHIATRY
JI Australas. Psychiatry
PD OCT
PY 2017
VL 25
IS 5
BP 451
EP 455
DI 10.1177/1039856217711054
PG 5
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA FI6GC
UT WOS:000412090100006
PM 28585448
DA 2025-06-11
ER

PT J
AU Morga, P
   Cieslik, B
   Sekulowicz, M
   Bujnowska-Fedak, M
   Drower, I
   Szczepanska-Gieracha, J
AF Morga, Paulina
   Cieslik, Blazej
   Sekulowicz, Malgorzata
   Bujnowska-Fedak, Maria
   Drower, Iris
   Szczepanska-Gieracha, Joanna
TI Low-Intensity Exercise as a Modifier of Depressive Symptoms and
   Self-Perceived Stress Level in Women with Metabolic Syndrome
SO JOURNAL OF SPORTS SCIENCE AND MEDICINE
LA English
DT Article
DE Low-intensity exercise; mental health; women; metabolic syndrome;
   physical activity
ID PHYSICAL-ACTIVITY; OXIDATIVE STRESS; HEALTH; OLD; INFLAMMATION; BENEFITS
AB The study aims to determine the impact of low-intensity exercise and psychoeducation on depressive symptoms and self-perceived stress in women with metabolic syndrome (MetS). Seventy-four women (mean age 69.35 +/- 7.20) were included in the study. Participants were divided into two groups: those with MetS (n = 33) and those without MetS (n = 41). Subjects participated in low-intensity general-fitness exercise sessions combined with psychoeducation distributed regularly over a 12-week period. Participants completed the Geriatric Depression Scale-15 (GDS) and the Stress Level Questionnaire (SLQ) before and after the intervention. All investigated parameters significantly decreased for the participants with metabolic syndrome after the intervention. The level of GDS in this group decreased by approximately 37% (p < 0.01), and SLQ by around 23% ( p < 0.01). Our results suggest, that low-intensity exercise combined with psychoeducation could lower depressive symptoms and stress level in women with MetS. However, the intervention does not lower anthropometric parameter scores.
C1 [Morga, Paulina; Sekulowicz, Malgorzata] Univ Sch Phys Educ Wroclaw, Fac Phys Educ, Wroclaw, Poland.
   [Cieslik, Blazej] Jan Dlugosz Univ Czestochowa, Fac Hlth Sci, Czestochowa, Poland.
   [Bujnowska-Fedak, Maria] Wroclaw Med Univ, Family Med Dept, Wroclaw, Poland.
   [Drower, Iris] Arizona State Univ, Mary Lou Fulton Teachers Coll, Tempe, AZ USA.
   [Szczepanska-Gieracha, Joanna] Univ Sch Phys Educ Wroclaw, Fac Physiotherapy, Wroclaw, Poland.
C3 Jan Dlugosz University; Wroclaw Medical University; Arizona State
   University; Arizona State University-Tempe
RP Cieslik, B (corresponding author), Jan Dlugosz Univ Czestochowa, Fac Hlth Sci, Czestochowa, Poland.
EM paulinamorga@gmail.com; b.cieslik@ujd.edu.pl;
   malgorzata.sekulowicz@awf.wroc.pl; maria.bujnowska-fedak@umed.wroc.pl;
   iris.drower@asu.edu; joanna.szczepanska@awf.wroc.pl
RI Bujnowska-Fedak, Maria Magdalena/ABD-2237-2021; Bujnowska-Fedak, Maria
   Magdalena/H-8550-2015; Cieslik, Blazej/J-4551-2016
OI Sekulowicz, Malgorzata/0000-0002-8702-3349; Bujnowska-Fedak, Maria
   Magdalena/0000-0002-4624-5025; Szczepanska-Gieracha,
   Joanna/0000-0001-5191-3799; Morga, Paulina/0000-0002-1462-0337; Cieslik,
   Blazej/0000-0001-7275-7860
FU Department of Health of the Wroclaw municipality
FX Authors thank the Department of Health of the Wroclaw municipality for
   their support of the Foundation for Senior Citizen Activation "Siwy Dym"
   in running a project of health promotion for elderly women. The authors
   received no financial support for the research, authorship, and/or
   publication of this article. The experiments comply with the current
   laws of the country in which they were performed. The authors have no
   conflict of interest to declare. The datasets generated during and/or
   analyzed during the current study are not publicly available, but are
   available from the corresponding author who was an organizer of the
   study.
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NR 44
TC 10
Z9 10
U1 0
U2 11
PU JOURNAL SPORTS SCIENCE & MEDICINE
PI BURSA
PA MEDICAL FACULTY ULUDAG UNIV, DEPT SPORTS MEDICINE, BURSA, 16059, TURKEY
SN 1303-2968
J9 J SPORT SCI MED
JI J. Sport. Sci. Med.
PD JUN
PY 2021
VL 20
IS 2
BP 222
EP 228
DI 10.52082/jssm.2021.222
PG 7
WC Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Sport Sciences
GA RQ3QP
UT WOS:000642336900006
PM 33948100
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Han, LKM
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   Brouwer, RM
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   van der Wee, NJA
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AF Han, Laura K. M.
   Schnack, Hugo G.
   Brouwer, Rachel M.
   Veltman, Dick J.
   van der Wee, Nic J. A.
   van Tol, Marie-Jose
   Aghajani, Moji
   Penninx, Brenda W. J. H.
TI Contributing factors to advanced brain aging in depression and anxiety
   disorders
SO TRANSLATIONAL PSYCHIATRY
LA English
DT Article
ID METABOLIC SYNDROME; LIFE EVENTS; RELIABILITY; AGE; VALIDITY;
   ASSOCIATION; NETHERLANDS; STRESS; RISK
AB Depression and anxiety are common and often comorbid mental health disorders that represent risk factors for aging-related conditions. Brain aging has shown to be more advanced in patients with major depressive disorder (MDD). Here, we extend prior work by investigating multivariate brain aging in patients with MDD, anxiety disorders, or both, and examine which factors contribute to older-appearing brains. Adults aged 18-57 years from the Netherlands Study of Depression and Anxiety underwent structural MRI. A pretrained brain-age prediction model based on >2000 samples from the ENIGMA consortium was applied to obtain brain-predicted age differences (brain PAD, predicted brain age minus chronological age) in 65 controls and 220 patients with current MDD and/or anxiety. Brain-PAD estimates were associated with clinical, somatic, lifestyle, and biological factors. After correcting for antidepressant use, brain PAD was significantly higher in MDD (+2.78 years, Cohen's d=0.25, 95% CI -0.10-0.60) and anxiety patients (+2.91 years, Cohen's d=0.27, 95% CI -0.08-0.61), compared with controls. There were no significant associations with lifestyle or biological stress systems. A multivariable model indicated unique contributions of higher severity of somatic depression symptoms (b=4.21 years per unit increase on average sum score) and antidepressant use (-2.53 years) to brain PAD. Advanced brain aging in patients with MDD and anxiety was most strongly associated with somatic depressive symptomatology. We also present clinically relevant evidence for a potential neuroprotective antidepressant effect on the brain-PAD metric that requires follow-up in future research.
C1 [Han, Laura K. M.; Veltman, Dick J.; Aghajani, Moji; Penninx, Brenda W. J. H.] Vrije Univ, Amsterdam Univ Med Ctr, Dept Psychiat, Amsterdam, Netherlands.
   [Han, Laura K. M.; Veltman, Dick J.; Aghajani, Moji; Penninx, Brenda W. J. H.] GGZ inGeest, Amsterdam Neurosci, Amsterdam, Netherlands.
   [Schnack, Hugo G.; Brouwer, Rachel M.] Univ Med Ctr Utrecht, UMCU Brain Ctr, Dept Psychiat, Utrecht, Netherlands.
   [Brouwer, Rachel M.] Vrije Univ Amsterdam, Ctr Neurogen & Cognit Res, Dept Complex Trait Genet, Amsterdam, Netherlands.
   [van der Wee, Nic J. A.] Leiden Univ, Leiden Inst Brain & Cognit, Leiden, Netherlands.
   [van der Wee, Nic J. A.] Univ Med Ctr Leiden, Dept Psychiat, Leiden, Netherlands.
   [van Tol, Marie-Jose] Univ Groningen, Univ Med Ctr Groningen, Cognit Neurosci Ctr, Groningen, Netherlands.
   [Aghajani, Moji] Leiden Univ, Sect Forens Family & Youth Care, Inst Educ & Child Studies, Leiden, Netherlands.
C3 Vrije Universiteit Amsterdam; Vrije Universiteit Amsterdam; Utrecht
   University; Utrecht University Medical Center; Vrije Universiteit
   Amsterdam; Leiden University; Leiden University Medical Center (LUMC);
   Leiden University - Excl LUMC; Leiden University; Leiden University
   Medical Center (LUMC); University of Groningen; Leiden University;
   Leiden University - Excl LUMC
RP Han, LKM (corresponding author), Vrije Univ, Amsterdam Univ Med Ctr, Dept Psychiat, Amsterdam, Netherlands.; Han, LKM (corresponding author), GGZ inGeest, Amsterdam Neurosci, Amsterdam, Netherlands.
EM l.han@amsterdamumc.nl
RI Penninx, Brenda/S-7627-2017; Han, Laura/AGV-3472-2022; Aghajani,
   Moji/AAL-9837-2020
OI Han, Laura/0000-0001-9647-3723; van Tol, Marie-Jose/0000-0002-9260-5490
FU Geestkracht program of the Netherlands Organization for Health Research
   and Development (Zon-MW) [10-000-1002]; VU University Medical Center;
   Leiden University Medical Center; University Medical Center Groningen;
   Scientific Institute for Quality of Healthcare [IQ healthcare];
   Netherlands Institute of Mental Health and Addiction [Trimbos
   Institute]; GGZ inGeest; Arkin; GGZ Rivierduinen; Lentis; GGZ Friesland;
   GGZ Drenthe; Lifebrain by the European Union's Horizon 2020 research and
   innovation programme [732592]; H2020 Societal Challenges Programme
   [732592] Funding Source: H2020 Societal Challenges Programme
FX The infrastructure for the Netherlands Study of Depression and Anxiety
   (https://www.nesda.nl) is funded through the Geestkracht program of the
   Netherlands Organization for Health Research and Development (Zon-MW,
   Grant number 10-000-1002) and is supported by participating universities
   and mental healthcare organizations (VU University Medical Center, GGZ
   inGeest, Arkin, Leiden University Medical Center, GGZ Rivierduinen,
   University Medical Center Groningen, Lentis, GGZ Friesland, GGZ Drenthe,
   Scientific Institute for Quality of Healthcare [IQ healthcare], and the
   Netherlands Institute of Mental Health and Addiction [Trimbos
   Institute]). LKMH and BWJHP are partly funded through Lifebrain, funded
   by the European Union's Horizon 2020 research and innovation programme
   (grant number 732592). We gratefully used the gtsummary package in R to
   create Table 1 [69]. Data sources are not available due to privacy
   issues, but we highly value scientific collaboration. Therefore, in
   principle, NESDA data are available to all scientific researchers
   working at noncommercial research organizations worldwide. Researchers
   can request either existing data for data analyses or bioanalysis.
   Please visit the online data overview for an extensive overview of the
   available data and NESDA's current output (www.nesda.nl).The used
   brain-age prediction model can be found on
   https://www.photon-ai.com/enigma_brainage/.This article was published as
   a preprint on medRxiv: https://doi.org/10.1101/2020.06.16.20132613.BWJHP
   has received research funding (not related to the current paper) from
   Boehringer Ingelheim and Jansen Research.
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NR 69
TC 39
Z9 40
U1 0
U2 17
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 2158-3188
J9 TRANSL PSYCHIAT
JI Transl. Psychiatr.
PD JUL 21
PY 2021
VL 11
IS 1
AR 402
DI 10.1038/s41398-021-01524-2
PG 11
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA TP5AY
UT WOS:000677611800003
PM 34290222
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Nuryana, Z
   Al Murshidi, G
   Rahman, A
AF Nuryana, Zalik
   Al Murshidi, Ghadah
   Rahman, Arif
TI Publication trends related to schizophrenia, mental health, and
   depression during COVID-19
SO ASIAN JOURNAL OF PSYCHIATRY
LA English
DT Article
DE Schizophrenia; Mental health; Depression; COVID-19; Asian Journal of
   Psychiatry
AB The aim of this article is to analyze publication trends related to schizophrenia, mental health, and depression during COVID-19 in the Asian Journal of Psychiatry. In 2020, 576 articles were identified using bibliometric analysis from scopus.com . According to the results, India had the most articles on schizophrenia, mental health, and depression, followed by China, Australia, Bangladesh, and Japan, during COVID-19. Meanwhile, the most frequently used keywords were schizophrenia (n = 39), COVID-19 (n = 35), mental health (n = 23), depression (n = 22), and adolescents (n = 12). These represent the trend of publications related to the topics discussed in 2020. Moreover, alternative research themes such as life quality, obsessive-compulsive disorder, metabolic syndrome, prevalence, and mental illness can be used in the future.
C1 [Nuryana, Zalik] Nanjing Normal Univ, Sch Educ Sci, 122 Ninghai Rd, Nanjing 210000, Peoples R China.
   [Nuryana, Zalik; Rahman, Arif] Univ Ahmad Dahlan, Dept Islamic Educ, Jl Ringrd Selatan, Bantul 55191, Daerah Istimewa, Indonesia.
   [Al Murshidi, Ghadah] United Arab Emirates Univ, Dept Curriculum & Instruct, Coll Educ, Al Ain, U Arab Emirates.
C3 Nanjing Normal University; Universitas Ahmad Dahlan; United Arab
   Emirates University
RP Nuryana, Z (corresponding author), Nanjing Normal Univ, Sch Educ Sci, 122 Ninghai Rd, Nanjing 210000, Peoples R China.
EM zalik.nuryana@pai.uad.ac.id
RI Nuryana, Zalik/AAJ-1136-2020
OI Al Murshidi, Ghadah/0000-0002-0230-2825
FU Nanjing Normal University, China; Universitas Ahmad Dahlan, Indonesia
FX The authors would like to thank Nanjing Normal University, China, and
   Universitas Ahmad Dahlan, Indonesia, for the granted supports.
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NR 15
TC 11
Z9 11
U1 3
U2 29
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1876-2018
EI 1876-2026
J9 ASIAN J PSYCHIATR
JI Asian J. Psychiatr.
PD DEC
PY 2021
VL 66
AR 102878
DI 10.1016/j.ajp.2021.102878
EA OCT 2021
PG 5
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychiatry
GA WO2GG
UT WOS:000712277500007
PM 34634657
OA Green Published
DA 2025-06-11
ER

PT J
AU Misra, A
   Vikram, NK
AF Misra, A
   Vikram, NK
TI Insulin resistance syndrome (Metabolic syndrome) and obesity in Asian
   Indians: Evidence and implications
SO NUTRITION
LA English
DT Review
DE Asian Indians; insulin resistance syndrome; obesity; abdominal obesity;
   hypertriglyceridemia; high-density lipoprotein cholesterol; physical
   activity; coronary heart disease
ID CORONARY-HEART-DISEASE; BODY-MASS INDEX; C-REACTIVE PROTEIN;
   CARDIOVASCULAR RISK-FACTORS; IMPAIRED GLUCOSE-TOLERANCE;
   DENSITY-LIPOPROTEIN CHOLESTEROL; TISSUE-PLASMINOGEN ACTIVATOR; DEPENDENT
   DIABETES-MELLITUS; INCREASED FIBRINOGEN LEVELS; APOLIPOPROTEIN-B GENE
AB OBJECTIVES: This review describes prevalence, determinants, and possible pathophysiologic mechanisms and suggests management and research directions for insulin resistance syndrome (metabolic syndrome) in Asian Indians.
   METHOD: We reviewed the topic using the terms Asian Indians, Asians, South Asians, and Indians coupled with the terms insulin resistance, hyperinsulinemia, metabolic syndrome, and obesity from the databases Pubmed (National Library of Medicine, Bethesda, MD, USA) and Current Contents (Institute for Scientific Information, Thomson Scientific, Philadelphia, PA, USA) and from non-indexed publications of the medical research and governmental institutions in India.
   RESULTS: Asian Indians have a high prevalence of insulin resistance syndrome that may underlie their greater than normal tendency to develop diabetes mellitus and early atherosclerosis. Important reasons could be their excess body fat and adverse body fat patterning including abdominal adiposity even when the body mass index is within the currently defined normal limits. Some of these features have been reported at birth and childhood. Whether Asian Indians also have tendency to develop insulin resistance de novo, independent of total or regional adiposity, needs further investigation. Underlying genetic tendency or early-life adverse events may contribute to such a phenotype, but lifestyle factors alone or modulated by inherited factors appear to play an important role because obesity and dyslipidemia become worse with urbanization and migration. Systemic stress may contribute to insulin resistance syndrome in the intra-country and inter-country migrant Asian Indians.
   CONCLUSIONS: High prevalences of excess body fat, adverse body fat patterning, hypertriglyceridemia, and insulin resistance beginning at a young age have been consistently recorded in Asian Indians irrespective of their geographic locations. These data suggest that primary prevention strategies should be initiated early in this ethnic group. (C)EIsevier Inc. 2004.
C1 All India Inst Med Sci, Dept Internal Med, New Delhi 110029, India.
   All India Inst Med Sci, Dept Med, New Delhi 110029, India.
C3 All India Institute of Medical Sciences (AIIMS) New Delhi; All India
   Institute of Medical Sciences (AIIMS) New Delhi
RP All India Inst Med Sci, Dept Internal Med, New Delhi 110029, India.
EM anoopmisra@metabolicresearchindia.com
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NR 235
TC 263
Z9 318
U1 0
U2 34
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0899-9007
EI 1873-1244
J9 NUTRITION
JI Nutrition
PD MAY
PY 2004
VL 20
IS 5
BP 482
EP 491
DI 10.1016/j.nut.2004.01.020
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 816JN
UT WOS:000221106300014
PM 15105039
DA 2025-06-11
ER

PT J
AU Waterreus, A
   Di Prinzio, P
   Watts, GF
   Castle, D
   Galletly, C
   Morgan, VA
AF Waterreus, A.
   Di Prinzio, P.
   Watts, G. F.
   Castle, D.
   Galletly, C.
   Morgan, V. A.
TI Metabolic syndrome in people with a psychotic illness: is cannabis
   protective?
SO PSYCHOLOGICAL MEDICINE
LA English
DT Article
DE Cannabis; cardiometabolic risk; metabolic syndrome; psychosis
ID CARDIOVASCULAR RISK-FACTORS; AUSTRALIAN NATIONAL-SURVEY; ENDOCANNABINOID
   SYSTEM; OVERWEIGHT PATIENTS; HEART-DISEASE; MARIJUANA USE; PREVALENCE;
   SCHIZOPHRENIA; DISORDERS; OBESITY
AB Background. Rates of the metabolic syndrome in people with psychotic illness are high. Emerging evidence suggests that cannabis use may have a positive impact on cardiometabolic risk factors in the general population, but little is known about its impact for people with psychotic illness. Our aim was to investigate whether the rate of the metabolic syndrome in people with psychotic illness was associated with frequency of cannabis use.
   Method. The 2010 Australian psychosis survey used a two-phase design to randomly select a nationally representative sample of 1825 adults with psychotic illness for interview and physical assessment. This study is based on 1813 participants who provided data on cannabis use. Multiple logistic regression was used to model the influence of frequency of cannabis use on the metabolic syndrome, adjusting for potential covariates including antipsychotic medication use, smoking, alcohol use and cognitive function.
   Results. One-third (33.0%) of participants had used cannabis in the past year. The proportion of non-users, occasional users and frequent users with the metabolic syndrome was 63.0, 51.7 and 43.5%, respectively (p < 0.001). In unadjusted analyses, both occasional use and frequent cannabis use were associated with significantly lower odds of the metabolic syndrome. In the adjusted analyses, the association between the metabolic syndrome and frequent cannabis use remained significant [odds ratio = 0.56, 95% confidence interval (CI) 0.39-0.80], but not the association with occasional use (odds ratio = 0.75, 95% CI 0.49-1.13).
   Conclusions. While cannabis use may be detrimental for mental health, these data suggest that it may also have a cardiometabolic protective effect. Further investigation is required to understand the mechanism underlying this paradoxical finding.
C1 [Waterreus, A.; Di Prinzio, P.; Morgan, V. A.] Univ Western Australia, Sch Psychiat & Clin Neurosci, Neuropsychiat Epidemiol Res Unit, Level 3 MRF Bldg,Rear 50 Murray St, Perth, WA 6000, Australia.
   [Watts, G. F.] Royal Perth Hosp, Cardiometab Clin, Ctr Cardiovasc Med, Perth, WA 6001, Australia.
   [Watts, G. F.] Univ Western Australia, Sch Med & Pharmacol, Perth, WA 6009, Australia.
   [Castle, D.] St Vincents Hosp, Melbourne, Vic, Australia.
   [Castle, D.] Univ Melbourne, Dept Psychiat, Melbourne, Vic, Australia.
   [Galletly, C.] Univ Adelaide, Adelaide, SA, Australia.
   [Morgan, V. A.] Univ Western Australia, Sch Psychiat & Clin Neurosci, Ctr Clin Res Neuropsychiat, Perth, WA 6009, Australia.
C3 University of Western Australia; East Metropolitan Health Service; Royal
   Perth Hospital; University of Western Australia; St Vincent's Health; St
   Vincent's Hospital Melbourne; NSW Health; St Vincents Hospital Sydney;
   University of Melbourne; University of Adelaide; University of Western
   Australia
RP Waterreus, A (corresponding author), Univ Western Australia, Sch Psychiat & Clin Neurosci, Neuropsychiat Epidemiol Res Unit, Level 3 MRF Bldg,Rear 50 Murray St, Perth, WA 6000, Australia.
EM anna.waterreus@uwa.edu.au
RI Watts, Gerald/HII-8530-2022; Morgan, Vera/U-4851-2019
OI Di Prinzio, Patsy/0000-0002-0761-5599; Castle,
   David/0000-0002-3075-1580; Watts, Gerald/0000-0003-2276-1524; Waterreus,
   Anna/0000-0002-1648-7701
FU Australian Government Department of Health and Ageing
FX This study was supported by the Australian Government Department of
   Health and Ageing.
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NR 53
TC 19
Z9 20
U1 0
U2 18
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
SN 0033-2917
EI 1469-8978
J9 PSYCHOL MED
JI Psychol. Med.
PD JUN
PY 2016
VL 46
IS 8
BP 1651
EP 1662
DI 10.1017/S0033291715002883
PG 12
WC Psychology, Clinical; Psychiatry; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA DL8XK
UT WOS:000375925300007
PM 26965714
DA 2025-06-11
ER

PT J
AU McCaffery, JM
   Niaura, R
   Todaro, JF
   Swan, GE
   Carmelli, D
AF McCaffery, JM
   Niaura, R
   Todaro, JF
   Swan, GE
   Carmelli, D
TI Depressive symptoms and metabolic risk in adult male twins enrolled in
   the national heart, lung, and blood institute twin study
SO PSYCHOSOMATIC MEDICINE
LA English
DT Article
DE depression; metabolic syndrome; twins; cardiovascular disease; diabetes;
   cholesterol
ID INSULIN-RESISTANCE SYNDROME; MYOCARDIAL-INFARCTION; FOLLOW-UP;
   GENERAL-POPULATION; GLUCOSE-METABOLISM; SYNDROME PREDICTS; MAJOR
   DEPRESSION; CARDIAC EVENTS; DISEASE; MEN
AB Objective: To determine the extent to which depressive symptoms are associated with metabolic risk factors and whether genetic or environmental factors account for this association. Method: Twin structural equation modeling was employed to estimate genetic and environmental contributions to the covariation of depressive symptoms, as indexed by the Centers for Epidemiological Studies-Depression Scale, and common variance among blood pressure, body mass index, waist-to-hip ratio, and serum triglycerides and glucose among 87 monozygotic and 86 dizygotic male twin pairs who participated in the NHLBI twin study. Results: Depressive symptoms were associated with individual components of the metabolic syndrome and common variance among the risk factors. Twin structural equation modeling indicated that the associations were attributable to environmental (nongenetic) factors. Conclusions: These results support the hypothesis that depressive symptoms may increase risk for a pattern of physiological risk consistent with the metabolic syndrome.
C1 Brown Med Sch, Ctr Behav Med, Providence, RI 02903 USA.
   Brown Med Sch, Ctr Prevent Med, Providence, RI 02903 USA.
   Miriam Hosp, Providence, RI 02906 USA.
   SRI Int, Menlo Pk, CA 94025 USA.
C3 Brown University; Brown University; Lifespan Health Rhode Island; Miriam
   Hospital; SRI International
RP Brown Med Sch, Ctr Behav Med, Coro Bldg,Suite 5000,1 Hoppin St, Providence, RI 02903 USA.
EM Jeanne_McCaffery@brown.edu
RI Niaura, Raymond/AAE-7319-2019
OI McCaffery, Jeanne/0000-0002-2166-5840
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NR 43
TC 90
Z9 103
U1 0
U2 8
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0033-3174
EI 1534-7796
J9 PSYCHOSOM MED
JI Psychosom. Med.
PD MAY-JUN
PY 2003
VL 65
IS 3
BP 490
EP 497
DI 10.1097/01.PSY.0000041545.52924.82
PG 8
WC Psychiatry; Psychology; Psychology, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry; Psychology
GA 683QH
UT WOS:000183160300023
PM 12764224
DA 2025-06-11
ER

PT J
AU Lunsford-Avery, JR
   Engelhard, MM
   Navar, AM
   Kollins, SH
AF Lunsford-Avery, Jessica R.
   Engelhard, Matthew M.
   Navar, Ann Marie
   Kollins, Scott H.
TI Validation of the Sleep Regularity Index in Older Adults and
   Associations with Cardiometabolic Risk
SO SCIENTIFIC REPORTS
LA English
DT Article
ID CARDIOVASCULAR-DISEASE INCIDENCE; NIGHT-SHIFT WORK; METABOLIC SYNDROME;
   SOCIAL JETLAG; DURATION; OBESITY; METAANALYSIS; ATHEROSCLEROSIS;
   MISALIGNMENT; VARIABILITY
AB Sleep disturbances, including insufficient sleep duration and circadian misalignment, confer risk for cardiometabolic disease. Less is known about the association between the regularity of sleep/wake schedules and cardiometabolic risk. This study evaluated the external validity of a new metric, the Sleep Regularity Index (SRI), among older adults (n = 1978; mean age 68.7 +/- 9.2), as well as relationships between the SRI and cardiometabolic risk using data from the Multi-Ethnic Study of Atherosclerosis (MESA). Results indicated that sleep irregularity was associated with delayed sleep timing, increased daytime sleep and sleepiness, and reduced light exposure, but was independent of sleep duration. Greater sleep irregularity was also correlated with 10-year risk of cardiovascular disease and greater obesity, hypertension, fasting glucose, hemoglobin A1C, and diabetes status. Finally, greater sleep irregularity was associated with increased perceived stress and depression, psychiatric factors integrally tied to cardiometabolic disease. These results suggest that the SRI is a useful measure of sleep regularity in older adults. Additionally, sleep irregularity may represent a target for early identification and prevention of cardiometabolic disease. Future studies may clarify the causal direction of these effects, mechanisms underlying links between sleep irregularity and cardiometabolic risk, and the utility of sleep interventions in reducing cardiometabolic risk.
C1 [Lunsford-Avery, Jessica R.; Engelhard, Matthew M.; Kollins, Scott H.] Duke Univ, Med Ctr, Dept Psychiat & Behav Sci, Durham, NC 27708 USA.
   [Navar, Ann Marie] Duke Clin Res Inst, Durham, NC USA.
C3 Duke University; Duke University
RP Lunsford-Avery, JR (corresponding author), Duke Univ, Med Ctr, Dept Psychiat & Behav Sci, Durham, NC 27708 USA.
EM jessica.r.avery@duke.edu
RI Kollins, Scott/AAD-6291-2020
OI Kollins, Scott/0000-0001-6847-6935; Lunsford-Avery,
   Jessica/0000-0003-0264-6991; Engelhard, Matthew/0000-0003-4112-9639
FU National Heart, Lung, and Blood Institute (NHLBI) at the National
   Institutes of Health [N01-HC-95159, N01-HC-95160, N01-HC-95161,
   N01-HC-95162, N01-HC-95163, N01-HC-95164, N01-HC-95165, N01-HC-95166,
   N01-HC-95167, N01-HC-95168, N01-HC-95169]; NHLBI [R01 L098433];  [K23
   MH108704];  [K01 HL13341]
FX This research was supported by grants K23 MH108704 to Dr. Lunsford-Avery
   and K01 HL13341 to Dr. Navar. The Multi-Ethnic Study of Atherosclerosis
   (MESA) is supported by contracts N01-HC-95159 through N01-HC-95169 from
   the National Heart, Lung, and Blood Institute (NHLBI) at the National
   Institutes of Health. This Manuscript was prepared using MESA Research
   Materials obtained from the NHLBI Biologic Specimen and Data Repository
   Information Coordinating Center and does not necessarily reflect the
   opinions or views of the MESA or the NHLBI. MESA Sleep was supported by
   NHLBI R01 L098433 and data was obtained from the NHLBI National Sleep
   Research Repository (NSRR R24 HL114473). The authors thank the other
   investigators, the staff, and the participants of the MESA study for
   their valuable contributions. A full list of participating MESA
   investigators and institutions can be found at
   http://www.mesa-nhlbi.org.
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NR 51
TC 143
Z9 153
U1 1
U2 33
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD SEP 21
PY 2018
VL 8
AR 14158
DI 10.1038/s41598-018-32402-5
PG 11
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Science & Technology - Other Topics
GA GU4SY
UT WOS:000445276000002
PM 30242174
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Pearl, RL
   Wadden, TA
   Hopkins, CM
   Shaw, JA
   Hayes, MR
   Bakizada, ZM
   Alfaris, N
   Chao, AM
   Pinkasavage, E
   Berkowitz, RI
   Alamuddin, N
AF Pearl, Rebecca L.
   Wadden, Thomas A.
   Hopkins, Christina M.
   Shaw, Jena A.
   Hayes, Matthew R.
   Bakizada, Zayna M.
   Alfaris, Nasreen
   Chao, Ariana M.
   Pinkasavage, Emilie
   Berkowitz, Robert I.
   Alamuddin, Naji
TI Association Between Weight Bias Internalization and Metabolic Syndrome
   Among Treatment-Seeking Individuals with Obesity
SO OBESITY
LA English
DT Article
ID STIGMA; DISCRIMINATION; OVERWEIGHT; DEPRESSION; ADULTS; HEALTH; IMPACT;
   ATTITUDES; RACISM; LIFE
AB Objective: Weight stigma is a chronic stressor that may increase cardiometabolic risk. Some individuals with obesity self-stigmatize ( i. e., weight bias internalization, WBI). No study to date has examined whether WBI is associated with metabolic syndrome.
   Methods: Blood pressure, waist circumference, and fasting glucose, triglycerides, and high-density lipoprotein cholesterol were measured at baseline in 178 adults with obesity enrolled in a weight-loss trial. Medication use for hypertension, dyslipidemia, and prediabetes was included in criteria for metabolic syndrome. One hundred fifty-nine participants ( 88.1% female, 67.3% black, mean BMI541.1 kg/m(2)) completed the Weight Bias Internalization Scale and Patient Health Questionnaire ( PHQ-9, to assess depressive symptoms). Odds ratios and partial correlations were calculated adjusting for demographics, BMI, and PHQ-9 scores.
   Results: Fifty-one participants ( 32.1%) met criteria for metabolic syndrome. Odds of meeting criteria for metabolic syndrome were greater among participants with higher WBI, but not when controlling for all covariates ( OR=1.46, 95% CI=1.00-2.13, P=0.052). Higher WBI predicted greater odds of having high triglycerides ( OR=1.88, 95% CI=1.14-3.09, P=0.043). Analyzed categorically, high ( vs. low) WBI predicted greater odds of metabolic syndrome and high triglycerides ( Ps<0.05).
   Conclusions: Individuals with obesity who self-stigmatize may have heightened cardiometabolic risk. Biological and behavioral pathways linking WBI and metabolic syndrome require further exploration.
C1 [Pearl, Rebecca L.; Wadden, Thomas A.; Hopkins, Christina M.; Shaw, Jena A.; Hayes, Matthew R.; Bakizada, Zayna M.; Chao, Ariana M.; Pinkasavage, Emilie; Berkowitz, Robert I.; Alamuddin, Naji] Univ Penn, Dept Psychiat, Ctr Weight & Eating Disorders, Perelman Sch Med, Philadelphia, PA 19104 USA.
   [Hopkins, Christina M.] Duke Univ, Dept Psychol, Durham, NC 27706 USA.
   [Hayes, Matthew R.] Univ Penn, Sch Nursing, Dept Biobehav Hlth Sci, Philadelphia, PA 19104 USA.
   [Alfaris, Nasreen] Massachusetts Gen Hosp, Dept Med, Gastrointestinal Unit, Weight Ctr, Boston, MA 02114 USA.
   [Chao, Ariana M.] Univ Penn, Sch Nursing, Dept Family & Community Hlth, Philadelphia, PA 19104 USA.
   [Berkowitz, Robert I.] Childrens Hosp Philadelphia, Dept Psychiat & Behav Sci, Philadelphia, PA 19104 USA.
   [Alamuddin, Naji] Univ Penn, Dept Med, Inst Diabet Obes & Metab, Perelman Sch Med, Philadelphia, PA 19104 USA.
C3 University of Pennsylvania; Duke University; University of Pennsylvania;
   Harvard University; Harvard University Medical Affiliates; Massachusetts
   General Hospital; University of Pennsylvania; University of
   Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia;
   University of Pennsylvania
RP Pearl, RL (corresponding author), Univ Penn, Dept Psychiat, Ctr Weight & Eating Disorders, Perelman Sch Med, Philadelphia, PA 19104 USA.
EM rpearl@mail.med.upenn.edu
RI Pearl, Rebecca/GRS-0019-2022; Alfaris, Nasreen/AAA-2128-2021; Cobden,
   David/AGL-5940-2022; Alamuddin, Naji/LSK-0170-2024; Tronieri,
   Jena/O-9771-2016
OI Wadden, Thomas/0000-0002-0438-4609; Tronieri, Jena/0000-0003-3587-4130;
   Hopkins, Christina/0000-0003-4660-6641
FU Eisai Pharmaceutical Co.; NRSA postdoctoral fellowship from the NINR/NIH
   [T32NR007100]
FX This study was supported by an investigator-initiated grant from Eisai
   Pharmaceutical Co. (TAW). AMC was supported by an NRSA postdoctoral
   fellowship from the NINR/NIH #T32NR007100.
CR Alberti KGMM, 2009, CIRCULATION, V120, P1640, DOI 10.1161/CIRCULATIONAHA.109.192644
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NR 42
TC 116
Z9 145
U1 0
U2 19
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1930-7381
EI 1930-739X
J9 OBESITY
JI Obesity
PD FEB
PY 2017
VL 25
IS 2
BP 317
EP 322
DI 10.1002/oby.21716
PG 6
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA EL9WF
UT WOS:000394970100012
PM 28124502
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Leite, AA
   Costa, AJG
   de Lima, BDM
   Padilha, AVL
   de Albuquerque, EC
   Marques, CDL
AF Leite, Alice Abath
   Gesteira Costa, Aline Jurema
   Matheos de Lima, Beatriz de Arruda
   Lopes Padilha, Adriana Valentina
   de Albuquerque, Emidio Cavalcanti
   Lopes Marques, Claudia Diniz
TI Comorbidities in patients with osteoarthritis: frequency and impact on
   pain and physical function
SO REVISTA BRASILEIRA DE REUMATOLOGIA
LA English
DT Article
DE osteoarthritis; metabolic syndrome X; depression; chronic disease
ID OF-RHEUMATOLOGY CRITERIA; METABOLIC SYNDROME; CLINICAL COMORBIDITY;
   CLASSIFICATION; OBESITY; EPIDEMIOLOGY; DEPRESSION; PREVALENCE; ANXIETY;
   HEALTH
AB Introduction: As the prevalence of osteoarthritis (OA) increases with age, the coexistence of other chronic diseases is common. Objectives: To evaluate the frequency of comorbidities in OA patients and to measure their impact on pain and physical function of those patients. Methods: Cross-sectional study in OA patients of a public rheumatology clinic. Pain was measured by use of the Visual Analogue Scale (VAS) and physical function by use of the Lequesne's and SACRAH indices. A screening for depression was performed, as were the following measurements: anthropometric data; blood pressure; fasting glycemia; and lipid profile. Results: The study assessed 91 patients (mean age 59.3 years; 91.4% female). The metabolic syndrome frequency was 54.9%. Hypertension occurred in 75.8% of the patients, dyslipidemia in 52.6%, and obesity in 57.1%. The screening for depression was positive in 61.3% of patients. When comparing the metabolic syndrome components individually, patients with hypertension had higher SACRAH scores, with statistically significant differences (P = 0.035). For the other variables, no differences among the Lequesne's, SACRAH and VAS scores were observed. Conclusion: This group of OA patients showed a high frequency of depression, metabolic syndrome and its components in isolation, which can impact the pain and physical function of those patients. Such results showed the need for investigating and treating those comorbidities in OA patients.
C1 [Leite, Alice Abath; Gesteira Costa, Aline Jurema; Matheos de Lima, Beatriz de Arruda; Lopes Padilha, Adriana Valentina; de Albuquerque, Emidio Cavalcanti; Lopes Marques, Claudia Diniz] Inst Med Integral Prof Fernando Figueira IMIP, Recife, PE, Brazil.
C3 Instituto de Medicina Integral Professor Fernando Figueira (IMIP)
RP Marques, CDL (corresponding author), Rua Coelhos 300, BR-50070550 Recife, PE, Brazil.
EM claudia_reumatologia@terra.com.br
RI Costa, Aline/JDM-2967-2023; MARQUES, CLAUDIA/P-4008-2019
FU IMIP/CNPq
FX Financial support: Alice Abath received a Scientific Initiation
   scholarship from IMIP/CNPq. The authors declare no conflict of interest.
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NR 30
TC 23
Z9 24
U1 0
U2 7
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0482-5004
J9 REV BRAS REUMATOL
JI Rev. Bras. Reumatol.
PD MAR-APR
PY 2011
VL 51
IS 2
BP 113
EP 123
PG 11
WC Rheumatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Rheumatology
GA 972DZ
UT WOS:000306258300002
DA 2025-06-11
ER

PT J
AU von Känel, R
   Mausbach, BT
   Dimsdale, JE
   Mills, PJ
   Patterson, TL
   Ancoli-Israel, S
   Ziegler, MG
   Roepke, SK
   Chattillion, EA
   Allison, M
   Grant, I
AF von Kaenel, Roland
   Mausbach, Brent T.
   Dimsdale, Joel E.
   Mills, Paul J.
   Patterson, Thomas L.
   Ancoli-Israel, Sonia
   Ziegler, Michael G.
   Roepke, Susan K.
   Chattillion, Elizabeth A.
   Allison, Matthew
   Grant, Igor
TI Cardiometabolic Effects in Caregivers of Nursing Home Placement and
   Death of Their Spouse with Alzheimer's Disease
SO JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
LA English
DT Article
DE cardiovascular disease; caregivers; dementia; metabolic syndrome;
   psychological stress
ID CORONARY-HEART-DISEASE; METABOLIC SYNDROME; CARDIOVASCULAR-DISEASE;
   PSYCHOSOCIAL FACTORS; RISK-FACTORS; DEMENTIA; HEALTH; CONSEQUENCES;
   HYPERTENSION; TRANSITIONS
AB OBJECTIVES: To test the hypothesis that cardiometabolic risk is attenuated when caregivers are relieved of caregiving stress when the caregiving recipient transitions out of the home.
   DESIGN: Longitudinal.
   SETTING: Participants' homes.
   PARTICIPANTS: One hundred nineteen spousal caregivers of a patient with Alzheimer's disease (AD) and 55 noncaregiving controls (mean age of entire sample 75 +/- 8, 68% women).
   MEASUREMENTS: Participants underwent up to three yearly assessments of metabolic syndrome (MetS) factors related to adiposity, dyslipidemia, hypertension, and hyperglycemia. Changes in the total number of MetS factors (range: 0-5) 3 months after caregiver transitions were evaluated using random regression models with fixed and time-variant effects for sociodemographic and health-related covariates.
   RESULTS: Caregivers had a greater number of MetS factors over time than noncaregivers (1.78 +/- 0.13 vs 1.36 +/- 0.18, P = .008), which, after the death of the spouse, dropped by 0.46 +/- 0.16 (P = .003) being no longer different from those of noncaregivers; this effect was most prominently related to decreases in triglycerides (-22.2 +/- 11.0 mg/dL, P = .03), systolic blood pressure (-6.2 +/- 2.6 mmHg, P = .02), and diastolic blood pressure (-3.4 +/- 1.5 mmHg, P = .03). Placement of the spouse decreased the number of MetS factors only in caregivers with lower levels of depressive symptoms (-0.48 +/- 0.18, P = .01) and sleeping difficulties (-0.42 +/- 0.18, P = .02) but not in caregivers with higher levels in these measures at postplacement.
   CONCLUSION: High cardiometabolic risk in caregivers decreased to the level of that of noncaregivers within 3 months of death of the spouse with AD, although placement, a transition in the course of dementia caregiving, did not benefit cardiovascular health in highly distressed caregivers. J Am Geriatr Soc 59:2037-2044, 2011.
C1 [von Kaenel, Roland] Univ Hosp Bern, Inselspital, Div Psychosomat Med, Dept Gen Internal Med, CH-3010 Bern, Switzerland.
   [von Kaenel, Roland] Univ Bern, CH-3012 Bern, Switzerland.
   [von Kaenel, Roland; Mausbach, Brent T.; Dimsdale, Joel E.; Mills, Paul J.; Patterson, Thomas L.; Ancoli-Israel, Sonia; Grant, Igor] Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA.
   [Ziegler, Michael G.] Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA.
   [Allison, Matthew] Univ Calif San Diego, Dept Family & Prevent Med, La Jolla, CA 92093 USA.
   [Roepke, Susan K.; Chattillion, Elizabeth A.] Univ Calif San Diego, Joint Doctoral Program Clin Psychol, San Diego, CA 92103 USA.
   [Roepke, Susan K.; Chattillion, Elizabeth A.] San Diego State Univ, San Diego, CA 92182 USA.
C3 University of Bern; University Hospital of Bern; University of Bern;
   University of California System; University of California San Diego;
   University of California System; University of California San Diego;
   University of California System; University of California San Diego;
   University of California System; University of California San Diego;
   California State University System; San Diego State University
RP von Känel, R (corresponding author), Univ Hosp Bern, Inselspital, Div Psychosomat Med, Dept Gen Internal Med, CH-3010 Bern, Switzerland.
EM roland.vonkaenel@insel.ch
RI Ziegler, Michael/L-4728-2019; von Kanel, Roland/B-1811-2019
OI von Kanel, Roland/0000-0002-8929-5129; Allison,
   Matthew/0000-0003-0777-8272; Mausbach, Brent/0000-0003-2884-8743
FU NIH; NIH, National Institute on Aging [AG 15301];  [AG 03090];  [AG
   08415]
FX Sonia Ancoli-Israel: National Insitutes of Health (NIH) grants;
   consultant for Ferring Pharmaceuticals Inc., GlaxoSmithKline, Merck,
   NeuroVigil, Inc., Neurocrine Biosciences, Pfizer, Philips Respironics,
   Purdue Pharma LP, sanofi-aventis, Sepracor, Inc., Schering-Plough;
   honararia from Neurocrine Biosciences. Paul J. Mills: Received 3 grants
   from the NIH. This study was supported by the NIH, National Institute on
   Aging through award AG 15301 to Igor Grant. Additional support was
   provided through Award AG 03090 to Brent Mausbach and AG 08415 to Sonia
   Ancoli-Israel.
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NR 45
TC 24
Z9 27
U1 0
U2 7
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0002-8614
EI 1532-5415
J9 J AM GERIATR SOC
JI J. Am. Geriatr. Soc.
PD NOV
PY 2011
VL 59
IS 11
BP 2037
EP 2044
DI 10.1111/j.1532-5415.2011.03634.x
PG 8
WC Geriatrics & Gerontology; Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA 853FG
UT WOS:000297411000006
PM 22091921
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Xu, LL
   Zimmermann, M
   Forkey, H
   Griffin, J
   Wilds, C
   Morgan, WS
   Byatt, N
   McNeal, CJ
AF Xu, Lulu
   Zimmermann, Martha
   Forkey, Heather
   Griffin, Jessica
   Wilds, Caitlin
   Morgan, Wynne S.
   Byatt, Nancy
   McNeal, Catherine J.
TI How to Mitigate Risk of Premature Cardiovascular Disease Among Children
   and Adolescents with Mental Health Conditions
SO CURRENT ATHEROSCLEROSIS REPORTS
LA English
DT Review
DE Cardiovascular disease; Cardiometabolic; Mental health conditions; Toxic
   stress; Pharmacotherapy
ID ADVERSE CHILDHOOD EXPERIENCES; CORONARY-HEART-DISEASE; DAILY
   PHYSICAL-ACTIVITY; INDUCED WEIGHT-GAIN; PSYCHIATRIC-DISORDERS;
   CARDIOMETABOLIC RISK; SCIENTIFIC STATEMENT; INSULIN-RESISTANCE; YOUNG
   ADULTHOOD; TOXIC STRESS
AB Purpose of Review The goal of this article is to characterize the myriad of ways that children with mental health conditions can be at risk for premature cardiovascular disease (CVD) and various modalities to ameliorate this risk in childhood in order to improve the life course of these children. Review Findings Child and adolescent mental health conditions are a common yet underrecognized risk factor for premature CVD. The American Heart Association has recently included psychiatric conditions as a CVD risk factor (CVDRF) and the evidence linking childhood adversity to cardiometabolic disease. There are bidirectional and additive effects from the intrinsic emotional dysregulation and inflammatory changes from the mental health condition, the associations with risky health behaviors, and in some cases, metabolic side effects from pharmacotherapy. These pathways can be potentiated by toxic stress, a physiologic response to stressors from childhood adversity. Toxic stress is also associated with development of mental health conditions with epigenetic effects that can result in transgenerational inheritance of cardiometabolic risk. Exposure to toxic stress and mental health conditions in isolation sometimes compounded by pharmacotherapies used in treatment increase the risk of cardiometabolic diseases in childhood. The multiple pathways, which adversely influence cardiometabolic outcomes, encourage clinicians to consider strategies to mitigate these factors and justify the importance of early screening and treatment for CVDRFs. Mental health, health behaviors, and environmental factors co-occur and intersect in complex pathways that can increase CVD risk over the lifespan. Early detection and response can mitigate the risks associated with premature development of CVD.
C1 [Xu, Lulu; Zimmermann, Martha; Griffin, Jessica; Wilds, Caitlin; Morgan, Wynne S.; Byatt, Nancy] UMass Chan Med Sch, Dept Psychiat, Worcester, MA 01655 USA.
   [Forkey, Heather; Griffin, Jessica] UMass Chan Med Sch, Dept Pediat, Worcester, MA 01655 USA.
   [Wilds, Caitlin] Boston Child Study Ctr, Boston, MA 02116 USA.
   [McNeal, Catherine J.] Baylor Scott & White Hlth, Div Cardiol, Dept Internal Med, Temple, TX 76508 USA.
C3 University of Massachusetts System; UMass Chan Medical School;
   University of Massachusetts Worcester; University of Massachusetts
   System; University of Massachusetts Worcester; UMass Chan Medical
   School; Baylor Health Care System
RP McNeal, CJ (corresponding author), Baylor Scott & White Hlth, Div Cardiol, Dept Internal Med, Temple, TX 76508 USA.
EM catherine.mcneal@bswhealth.org
RI Forkey, Heather/MBG-5337-2025; Zimmermann, Martha/JPX-0057-2023
OI Xu, Lulu/0000-0002-8838-9879; , Jessica Griffin/0009-0009-9525-1390
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NR 114
TC 6
Z9 6
U1 0
U2 4
PU CURRENT MEDICINE GROUP
PI PHILADELPHIA
PA 400 MARKET STREET, STE 700, PHILADELPHIA, PA 19106 USA
SN 1523-3804
EI 1534-6242
J9 CURR ATHEROSCLER REP
JI Curr. Atheroscleros. Rep.
PD APR
PY 2022
VL 24
IS 4
BP 253
EP 264
DI 10.1007/s11883-022-00998-9
EA MAR 2022
PG 12
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Cardiovascular System & Cardiology
GA 0Q0AG
UT WOS:000772264200002
PM 35320835
OA Green Published, Bronze
DA 2025-06-11
ER

PT J
AU Park, SJ
   Jang, JW
   Kim, AY
   Hong, S
   Yuk, B
   Min, YW
   Park, KA
   Park, S
AF Park, Se Jin
   Jang, Jung Won
   Kim, Ah Young
   Hong, Seungyeon
   Yuk, Boram
   Min, Ye Won
   Park, Kyung A.
   Park, Subin
TI Association between Healthcare Utilization and Depression in Korean
   Women with Cardiovascular Conditions
SO PSYCHIATRY INVESTIGATION
LA English
DT Article
DE Coronary artery disease; Cardiovascular risk factors; Depression;
   Healthcare utilization
ID METABOLIC SYNDROME; MENTAL-DISORDERS; INCREASED RISK; SYMPTOMS; HEART;
   DISEASE; METAANALYSIS; PREVALENCE; MORTALITY; ANXIETY
AB Objective This study aimed to examine the associations between depression and both coronary artery disease (CAD) and cardiovascular risk factors (CVRs) in Korean women. Furthermore, this study sought to determine whether depression was associated with use of healthcare services in women with CAD or CVRs.
   Methods This cross-sectional study was conducted on 26,335 women who were aged 19 years or older, and who participated in the Korean National Health and Nutrition Examination Survey (2007-2014). Associations of prior diagnosis of depression with CAD and CVRs and with nonutilization of healthcare services were investigated.
   Results Women with depression had a higher prevalence of CAD and CVRs including obesity, hypertension, dyslipidemia, and metabolic syndrome than those without depression. In addition, depression was significantly associated with nonutilization of healthcare services in women with most CVRs.
   Conclusion Considering the high rate of comorbid depression with CAD or CVRs and the low levels of health service utilization in depressed patients, screening for common CVRs, such as obesity, hypertension, and dyslipidemia, should be provided for patients with depression in mental health care settings.
C1 [Park, Se Jin; Jang, Jung Won; Kim, Ah Young; Hong, Seungyeon; Yuk, Boram; Min, Ye Won; Park, Kyung A.; Park, Subin] Natl Ctr Mental Hlth, Mental Hlth Res Inst, Dept Res Planning, 127 Yongmasan Ro, Seoul 04933, South Korea.
   [Jang, Jung Won; Park, Kyung A.] Hanyang Univ, Grad Sch, Dept Hlth Sci, Seoul, South Korea.
C3 Hanyang University
RP Park, S (corresponding author), Natl Ctr Mental Hlth, Mental Hlth Res Inst, Dept Res Planning, 127 Yongmasan Ro, Seoul 04933, South Korea.
EM subin-21@hanmail.net
OI Jang, Jungwon/0000-0002-9702-2809
FU National Center for Mental Health, Ministry of Health & Welfare,
   Republic of Korea [R2017-A]
FX This study was supported by an Intramural Research Grant (No R2017-A)
   from the National Center for Mental Health, Ministry of Health &
   Welfare, Republic of Korea.
CR Abrams RC, 2002, AM J PSYCHIAT, V159, P1724, DOI 10.1176/appi.ajp.159.10.1724
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   ,, 2008, The global burden of disease: 2004 update
NR 32
TC 1
Z9 3
U1 0
U2 2
PU KOREAN NEUROPSYCHIATRIC ASSOC
PI SEOUL
PA RN 522, G-FIVE CENTRAL PLAZA 1685-8 SEOCHO 4-DONG, SEOCHO-GU, SEOUL,
   137-882, SOUTH KOREA
SN 1738-3684
EI 1976-3026
J9 PSYCHIAT INVEST
JI Psychiatry Investig.
PD NOV
PY 2017
VL 14
IS 6
BP 801
EP 807
DI 10.4306/pi.2017.14.6.801
PG 7
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA FM5TQ
UT WOS:000415103900012
PM 29209384
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Abe, T
   Okuyama, K
   Motohiro, A
   Shiratsuchi, D
   Isomura, M
AF Abe, Takafumi
   Okuyama, Kenta
   Motohiro, Atsushi
   Shiratsuchi, Daijo
   Isomura, Minoru
TI Association between different types of physical activity and
   occupational stress in Japanese workers: a cross-sectional study
SO INDUSTRIAL HEALTH
LA English
DT Article
DE Workers; Stress check program; Physical activity; Health management;
   Socio-economic status
ID PSYCHOSOCIAL STRESS; METABOLIC SYNDROME; PERCEIVED STRESS;
   MENTAL-HEALTH; TIME; CORTISOL; METAANALYSIS; PARADOX; PROGRAM
AB This cross-sectional study investigated the association between different types of physical activity (PA) and occupational psychological and physical stress responses among workers in Japan. Stress responses were assessed using the Brief Job Stress Questionnaire. Work-related PA (time spent sitting, sitting bouts, standing, walking, engaging in heavy labor, and moderate-to-vigorous PA [MVPA]) and exercise-based PA (frequencies [times/week] of flexibility and muscle-strengthening activity, and walking) were measured using a questionnaire. Multiple linear regression was performed to examine the association between each type of PA and stress responses. Participants who engaged in >108 min/day of work-related MVPA exhibited a statistically significant association with higher psychological stress responses when compared to those who engaged in 0-42 min/day of work-related MVPA. For exercise-based PA, participants who engaged in flexibility activity or walking five or more times/week, or muscle-strengthening activity one to three times/week, demonstrated significantly lower psychological stress responses compared to those who did not exercise. Participants who engaged in flexibility activity five or more times/week demonstrated significantly lower physical stress responses compared to those who did not exercise. This study suggests that work-related MVPA is associated with higher psychological stress responses, while exercise-based PA is associated with lower psychological or physical stress responses.
C1 [Abe, Takafumi; Okuyama, Kenta; Motohiro, Atsushi; Isomura, Minoru] Shimane Univ, Ctr Community based Healthcare Res & Educ CoHRE, Head Off Res & Acad Informat, Matsue, Japan.
   [Okuyama, Kenta] Lund Univ, Ctr Primary Hlth Care Res, Dept Clin Sci Malmo, Lund, Sweden.
   [Motohiro, Atsushi] Canvas Inc, Kyoto, Japan.
   [Shiratsuchi, Daijo] Kagoshima Univ, Fac Med, Sch Hlth Sci, Dept Phys Therapy, Kagoshima, Japan.
   [Isomura, Minoru] Shimane Univ, Fac Human Sci, Matsue, Japan.
C3 Shimane University; Lund University; Kagoshima University; Shimane
   University
RP Abe, T (corresponding author), Shimane Univ, Ctr Community based Healthcare Res & Educ CoHRE, Head Off Res & Acad Informat, Matsue, Japan.
EM t-abe@med.shimane-u.ac.jp
RI Shiratsuchi, Daijo/HPB-7205-2023
FU Shimane healthcare business subsidy from the Shimane Prefectural
   Govern-ment
FX <BOLD>Funding</BOLD> This work was supported by the Shimane healthcare
   business subsidy from the Shimane Prefectural Govern-ment.
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   World Health Organization, Protecting Workers' Health Series, V3
NR 44
TC 4
Z9 4
U1 2
U2 6
PU NATL INST OCCUPATIONAL SAFETY & HEALTH, JAPAN
PI KAWASAKI KANAGAWA
PA 21-1 NAGAO 6-CHOME TAMA-KU, KAWASAKI KANAGAWA, 214, JAPAN
SN 0019-8366
EI 1880-8026
J9 IND HEALTH
JI Ind. Health
PY 2024
VL 62
IS 4
BP 227
EP 236
DI 10.2486/indhealth.2023-0092
PG 10
WC Environmental Sciences; Public, Environmental & Occupational Health;
   Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health; Toxicology
GA A4J4D
UT WOS:001282208300002
PM 38233117
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Ortega-Montiel, J
   Posadas-Romero, C
   Ocampo-Arcos, W
   Medina-Urrutia, A
   Cardoso-Saldaña, G
   Jorge-Galarza, E
   Posadas-Sánchez, R
AF Ortega-Montiel, Janinne
   Posadas-Romero, Carlos
   Ocampo-Arcos, Wendy
   Medina-Urrutia, Aida
   Cardoso-Saldana, Guillermo
   Jorge-Galarza, Esteban
   Posadas-Sanchez, Rosalinda
TI Self-perceived stress is associated with adiposity and atherosclerosis.
   The GEA Study
SO BMC PUBLIC HEALTH
LA English
DT Article
ID METABOLIC SYNDROME; PSYCHOLOGICAL STRESS; METAANALYSIS; WOMEN; RISK; MEN
AB Background: A growing body of evidence suggests that psychological stress is an independent cardiovascular risk factor. Obesity prevalence shows accelerating trends worldwide, and is known to be associated with a range of comorbidities and survival. The aim of this study was to assess the relationship between self-perceived psychological stress with parameters of adiposity, metabolic syndrome, and subclinical atherosclerosis in Mexican participants.
   Methods: Metabolic Syndrome was defined using the Adult Treatment Panel III criteria, obesity was defined as BMI >30, subclinical atherosclerosis disease was determined by computed tomography, and carotid intima media thickness was determined by ultrasonography. Self-perceived psychological stress was assessed using a single-item questionnaire.
   Results: A total of 1243 control subjects were included in the sample, mean age 54.2 +/- 9 years old; the prevalence of chronic self-perceived psychological stress (>5 years) was 10.13 %, female gender (62.7 %), obesity prevalence (48.4 %), and self-reporting sedentary lifestyle (56.3 %). The chronic stressed cohort presented higher subcutaneous abdominal fat content (285 vs 319 cm(2)), and carotid intima media thickness (0.63 vs 0.66 mm; p < 0.01 for both). However, after adjustment for lifestyle/social covariates (Model 1) and biological mediators (Model 2), chronic self-perceived stress was independently associated with obesity in men (OR 2.85, 95 % CI 1.51 -5.40) and carotid atherosclerosis in women (OR 2.262, 95 % CI 1.47 - 4.67; p < 0.01 for both).
   Conclusion: Our study suggests that self-reported chronic stress is an independent risk factor for obesity in men. In addition, carotid atherosclerosis was also found to be an independent risk factor in women in a Mexican population sample.
C1 [Ortega-Montiel, Janinne; Posadas-Romero, Carlos; Ocampo-Arcos, Wendy; Medina-Urrutia, Aida; Cardoso-Saldana, Guillermo; Jorge-Galarza, Esteban; Posadas-Sanchez, Rosalinda] Natl Inst Cardiol Ignacio Chavez, Dept Endocrinol, Mexico City 14080, DF, Mexico.
C3 National Institute of Cardiology - Mexico
RP Posadas-Sánchez, R (corresponding author), Natl Inst Cardiol Ignacio Chavez, Dept Endocrinol, Juan Badiano 1 Col Secc 16, Mexico City 14080, DF, Mexico.
EM rossy_posadas_s@yahoo.it
RI Jorge-Galarza, Esteban/AAF-6915-2020
OI Ortega, Janinne/0000-0001-8196-6648; Jorge-Galarza,
   Esteban/0000-0002-7748-4678
FU Consejo Nacional de Ciencia y Tecnologia (CONACyT) [SALUD-2010-2-150537]
FX This study was supported by Consejo Nacional de Ciencia y Tecnologia
   (CONACyT) project number SALUD-2010-2-150537. The authors thank Eric
   Kimura Hayama MD, chief of the Department of Cardiac Tomography at the
   INCICH, for his contribution with the magnetic resonance images.
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NR 31
TC 28
Z9 35
U1 1
U2 10
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2458
J9 BMC PUBLIC HEALTH
JI BMC Public Health
PD AUG 14
PY 2015
VL 15
AR 780
DI 10.1186/s12889-015-2112-8
PG 6
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA CO9UD
UT WOS:000359520600004
PM 26271468
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Armborst, D
   Metzner, C
   Alteheld, B
   Bitterlich, N
   Rösler, D
   Siener, R
AF Armborst, Deborah
   Metzner, Christine
   Alteheld, Birgit
   Bitterlich, Norman
   Roesler, Daniela
   Siener, Roswitha
TI Impact of a Specific Amino Acid Composition with Micronutrients on
   Well-Being in Subjects with Chronic Psychological Stress and Exhaustion
   Conditions: A Pilot Study
SO NUTRIENTS
LA English
DT Article
DE stress management; perceived stress questionnaire (PSQ(30)); dietary
   supplement; hypothalamus-pituitary-adrenal axis
ID PERCEIVED STRESS; METABOLIC SYNDROME; COGNITIVE FUNCTION; QUESTIONNAIRE
   PSQ; ALLOSTATIC LOAD; HAIR CORTISOL; PART 1; BRAIN; TRYPTOPHAN; BURNOUT
AB Chronic work-life stress leads to dysfunction of the hypothalamus-pituitary-adrenal axis, the autonomic nervous system, and the serotonergic system, with resultant impairment of overall well-being. Aim of the study was to improve perceived stress by a specific amino acid composition with micronutrients in the verum versus placebo group. A total of 59 participants (18-65 years) with self-reported perceived chronic stress and exhaustion conditions participated in this randomized, double-blind, placebo-controlled study. The Perceived Stress Questionnaire (PSQ(30)), amino acid profile, anthropometric, clinical, blood, urine parameters, and dietary intake were assessed. After 12 weeks, the verum group achieved significantly greater improvements in the total PSQ(30) score compared with the placebo group. In the verum group, serum taurine concentration, folic acid concentration, urinary magnesium excretion, and the ratio of l-tryptophan to the sum of competing amino acids rose significantly. In the placebo group, serum concentrations of serotonin, protein, and magnesium decreased significantly, whereas the cardiometabolic risk parameters body weight, body mass index, waist circumference, and waist-to-height ratio increased significantly. Compared with placebo, the verum supplementation resulted in a higher improvement in perceived stress. Beneficial effects on the serotonergic system and preventive effects on magnesium homeostasis and some cardiometabolic risk factors were supposed. Additional effects might be caused by the optimized food intake.
C1 [Armborst, Deborah; Siener, Roswitha] Univ Bonn, Dept Urol, Med Nutr Sci, Sigmund Freud Str 25, D-53105 Bonn, Germany.
   [Metzner, Christine; Roesler, Daniela] Bonn Educ Assoc Dietet rA, Fuerst Pueckler Str 44, D-50935 Cologne, Germany.
   [Metzner, Christine] Uniklin RWTH Aachen, Dept Internal Med 3, Pauwelsstr 44, D-52074 Aachen, Germany.
   [Alteheld, Birgit] Univ Bonn, Dept Nutr & Food Sci, Nutr Physiol, Nussallee 9, D-53115 Bonn, Germany.
   [Bitterlich, Norman] Med & Serv Ltd, Dept Biostat, Boettcherstr 10, D-09117 Chemnitz, Germany.
C3 University of Bonn; RWTH Aachen University; RWTH Aachen University
   Hospital; University of Bonn
RP Armborst, D (corresponding author), Univ Bonn, Dept Urol, Med Nutr Sci, Sigmund Freud Str 25, D-53105 Bonn, Germany.
EM s7dearmb@uni-bonn.de; info-bfd@t-online.de; b.alteheld@uni-bonn.de;
   bitterlich@medizinservice-sachsen.de; office@bfdev.de;
   Roswitha.Siener@ukbonn.de
FU Kyberg Vital GmbH, Unterhaching, Germany
FX We would like to express our gratitude to those who participated in the
   study. The research was funded by Kyberg Vital GmbH, Unterhaching,
   Germany.
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NR 100
TC 8
Z9 9
U1 0
U2 13
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD MAY
PY 2018
VL 10
IS 5
AR 551
DI 10.3390/nu10050551
PG 23
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nutrition & Dietetics
GA GJ3LI
UT WOS:000435196000025
PM 29710825
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Kozumplik, O
   Uzun, S
AF Kozumplik, Oliver
   Uzun, Suzana
TI METABOLIC SYNDROME IN PATIENTS WITH DEPRESSIVE DISORDER - FEATURES OF
   COMORBIDITY
SO PSYCHIATRIA DANUBINA
LA English
DT Article
DE depressive disorder; metabolic syndrome; antidepressants; side effects
ID MAJOR DEPRESSION; SYMPTOMS; ASSOCIATION; ANXIETY; ADULTS; HEALTH; RISK;
   PREVALENCE; PREDICTS; OBESITY
AB Background: Depression is associated with increased physical morbidity and overall mortality. The results of a previous investigation on the relationship of the metabolic syndrome and its single components with coronary heart disease, cardiovascular disease (CVD), and all-cause mortality suggested that the metabolic syndrome is a marker of CVD risk, but not above and beyond the risk associated with its individual components. The aim of this article is to review literature regarding prevalence of metabolic syndrome in patients with depressive disorder, and association between metabolic syndrome and depression.
   Content analysis of literature: Literature research included structured searches of Medline and other publications on the subject of metabolic syndrome, particularly prevalence of metabolic syndrome in patients with depressive disorder, and association between metabolic syndrome and depression.
   Conclusion: Prevalence of the metabolic syndrome in patients with depression is high and varies among the analysed studies. Some investigations showed association between metabolic syndrome and depression. Further investigations are necessary in order to clarify the association between metabolic syndrome and depression.
C1 [Kozumplik, Oliver; Uzun, Suzana] Vrapce Psychiat Hosp, Univ Dept, Zagreb 10090, Croatia.
RP Kozumplik, O (corresponding author), Vrapce Psychiat Hosp, Univ Dept, Bolnicka Cesta 32, Zagreb 10090, Croatia.
EM okozumplik@hotmail.com
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NR 30
TC 17
Z9 17
U1 0
U2 8
PU MEDICINSKA NAKLADA
PI ZAGREB
PA VLASKA 69, HR-10000 ZAGREB, CROATIA
SN 0353-5053
J9 PSYCHIAT DANUB
JI Psychiatr. Danub.
PD MAR
PY 2011
VL 23
IS 1
BP 84
EP 88
PG 5
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 752OT
UT WOS:000289702700014
PM 21448104
DA 2025-06-11
ER

PT J
AU Dima-Cozma, C
   Patacchioli, FR
   Ghiciuc, CM
   Szalontay, A
   Mitu, F
   Azoicai, D
AF Dima-Cozma, Corina
   Patacchioli, Francesca Romana
   Ghiciuc, Cristina Mihaela
   Szalontay, Andreea
   Mitu, Florin
   Azoicai, Doina
TI Current Perspectives in Stress Research and Cardiometabolic Risk
SO REVISTA DE CERCETARE SI INTERVENTIE SOCIALA
LA English
DT Article
DE stress; coping; cardiometabolic risk; cortisol; autonomic nervous system
ID CORONARY-HEART-DISEASE; METABOLIC SYNDROME; ALLOSTATIC LOAD; RESPONSES;
   HEALTH; ADAPTATION; CORTISOL; STROKE
AB The most important objective of this research was to analyze and discuss the current relationship between the level of stress perception and the consequences on cardiometabolic risk in population. The study was based on a literature review, including books, published articles and interne information, as well as on the author's own experience in this field, regarding the most important concepts about stress, the mediators and systems involved, methods of assessment and evidences about the influences of stress on cardiac, endocrine and metabolic system. Stress and coping with stress have been identified as important variables affecting health, now recognized to be involved in pathogenesis of many diseases: cardiometabolic, respiratory and digestive pathologies, cancer, neuroendocrine and psychiatric disorders. Glucocorticoids, catecholamines, pro- and antiinflammatory cytokines and the parasympathetic nervous system are involved in the adaptation to stressors. The overload of these allostatic systems is characterized by persistent high levels of stress mediators and damaging effects on human health. The stress assessment combine the rating scales for self-evaluation and the laboratory tests. From the medical point of view, the most important step forward in the stress research was made by using salivary stress markers. Measuring cortisol, alpha-amylase, or dehydroepiandrosterone in saliva became a reliable method of investigating stress in human because avoid venipuncture and offer the possibility of self-collection at home or at work, several times per day. Stress markers were significantly increased in metabolic syndrome, hypertension, stroke, ischemic heart disease and heart failure.
C1 [Dima-Cozma, Corina; Mitu, Florin] Univ Med & Pharm Grigore T Popa, Dept Med 1, Discipline Med Semiol, Cardiovasc Rehabil Clin, Iasi 700115, Romania.
   [Patacchioli, Francesca Romana] Univ Roma La Sapienza, Dept Physiol & Pharmacol V Erspamer, I-00185 Rome, Italy.
   [Ghiciuc, Cristina Mihaela] Univ Med & Pharm Grigore T Popa, Dept Pharmacol, Iasi 700115, Romania.
   [Szalontay, Andreea] Univ Med & Pharm Grigore T Popa, Dept Psychiat, Iasi 700115, Romania.
   [Azoicai, Doina] Univ Med & Pharm Grigore T Popa, Fac Med, Discipline Primary Hlth Care & Epidemiol, Iasi 700115, Romania.
C3 Grigore T Popa University of Medicine & Pharmacy; Sapienza University
   Rome; Grigore T Popa University of Medicine & Pharmacy; Grigore T Popa
   University of Medicine & Pharmacy; Grigore T Popa University of Medicine
   & Pharmacy
RP Dima-Cozma, C (corresponding author), Univ Med & Pharm Grigore T Popa, Dept Med 1, Discipline Med Semiol, Cardiovasc Rehabil Clin, 16 Univ St, Iasi 700115, Romania.
EM corinadimacozma@yahoo.com; francesca.patacchioli@uniroma1.it;
   c_ghiciuc@yahoo.com; andrszal@yahoo.com; mitu.florin@yahoo.com;
   doina.azoicai@gmail.com
RI Szalontay, Andreea Silvana/GXZ-9004-2022; Mitu, Florin/AAX-5769-2020;
   Patacchioli, Francesca Romana/AAD-4183-2022; Ghiciuc,
   Cristina/AAA-3942-2019; AZOICAI, DOINA/HDO-6161-2022
OI AZOICAI, DOINA/0000-0003-0423-4085
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NR 49
TC 17
Z9 17
U1 0
U2 16
PU EXPERT PROJECTS PUBLISHING
PI IASI
PA IASI, STR VOINESTI 63, IASI, 700615, ROMANIA
SN 1583-3410
EI 1584-5397
J9 REV CERCET INTERV SO
JI Rev. Cercet. Interv. Soc.
PD JUN
PY 2014
VL 45
BP 175
EP 188
PG 14
WC Social Sciences, Interdisciplinary
WE Social Science Citation Index (SSCI)
SC Social Sciences - Other Topics
GA AK7IT
UT WOS:000338602700013
DA 2025-06-11
ER

PT J
AU Liu, X
   Miller, YD
   Burton, NW
   Brown, WJ
AF Liu, X.
   Miller, Y. D.
   Burton, N. W.
   Brown, W. J.
TI RETRACTED: A preliminary study of the effects of Tai Chi and Qigong
   medical exercise on indicators of metabolic syndrome, glycaemic control,
   health-related quality of life, and psychological health in adults with
   elevated blood glucose (Retracted Article)
SO BRITISH JOURNAL OF SPORTS MEDICINE
LA English
DT Article; Retracted Publication
ID INSULIN-RESISTANCE; OLDER-ADULTS; DEPRESSION; HYPERTENSION; BENEFITS;
   NIDDM
AB Objectives To evaluate the feasibility, acceptability and effects of a Tai Chi and Qigong exercise programme in adults with elevated blood glucose.
   Design, Setting, and Participants A single group pre post feasibility trial with 11 participants (3 male and 8 female; aged 42-65 years) with elevated blood glucose.
   Intervention Participants attended Tai Chi and Qigong exercise training for 1 to 1.5 h, 3 times per week for 12 weeks, and were encouraged to practise the exercises at home.
   Main Outcome Measures Indicators of metabolic syndrome (body mass index (BMI), waist circumference, blood pressure, fasting blood glucose, triglycerides, HDL-cholesterol); glucose control (HbA1c, fasting insulin and insulin resistance (HOMA)); health-related quality of life; stress and depressive symptoms.
   Results There was good adherence and high acceptability. There were significant improvements in four of the seven indicators of metabolic syndrome including BMI (mean difference -1.05, p<0.001), waist circumference (-2.80 cm, p<0.05), and systolic (-11.64 mm Hg, p<0.01) and diastolic blood pressure (-9.73 mm Hg, p<0.001), as well as in HbA1c (-0.32%, p<0.01), insulin resistance (-0.53, p<0.05), stress (-2.27, p<0.05), depressive symptoms (-3.60, p<0.05), and the SF-36 mental health summary score (5.13, p<0.05) and subscales for general health (19.00, p<0.01), mental health (10.55, p<0.01) and vitality (23.18, p<0.05).
   Conclusions The programme was feasible and acceptable and participants showed improvements in metabolic and psychological variables. A larger controlled trial is now needed to confirm these promising preliminary results.
C1 [Brown, W. J.] Univ Queensland, Sch Human Movement Studies, St Lucia, Qld 4072, Australia.
C3 University of Queensland
RP Brown, WJ (corresponding author), Univ Queensland, Sch Human Movement Studies, Level 5,Bldg 26, St Lucia, Qld 4072, Australia.
EM wbrown@hms.uq.edu.au
RI Miller, Yvette/V-9561-2019; Brown, Wendy/A-1553-2016; Brown, Wendy
   J/G-2201-2010; Burton, Nicola/G-3313-2010
OI Brown, Wendy J/0000-0001-9093-4509; Burton, Nicola/0000-0002-3221-2265;
   Miller, Yvette D/0000-0002-5393-7142
FU Diabetes Australia Research Trust; University of Queensland; NHMRC
   [252977, 301200]
FX This research project was funded by a grant from the Diabetes Australia
   Research Trust. Dr Liu was the recipient of a University of Queensland
   scholarship. Dr Miller and Dr Burton were supported by NHMRC capacity
   building (Owen, Brown, Bauman and Trost; #252977) and programe (Owen,
   Bauman and Brown; #301200) grants in physical activity and health at the
   School of Human Movement Studies, University of Queensland.
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NR 38
TC 53
Z9 67
U1 0
U2 41
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 0306-3674
EI 1473-0480
J9 BRIT J SPORT MED
JI Br. J. Sports Med.
PD AUG
PY 2010
VL 44
IS 10
BP 704
EP 709
DI 10.1136/bjsm.2008.051144
PG 6
WC Sport Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Sport Sciences
GA 635MC
UT WOS:000280658800005
PM 18927159
DA 2025-06-11
ER

PT J
AU Révész, D
   Verhoeven, JE
   Milaneschi, Y
   Penninx, BWJH
AF Revesz, D.
   Verhoeven, J. E.
   Milaneschi, Y.
   Penninx, B. W. J. H.
TI Depressive and anxiety disorders and short leukocyte telomere length:
   mediating effects of metabolic stress and lifestyle factors
SO PSYCHOLOGICAL MEDICINE
LA English
DT Article
DE Anxiety disorder; cellular aging; depression; physiological stress;
   telomere length
ID CIGARETTE-SMOKING; PSYCHIATRIC-DISORDERS; CLINICAL ANXIETY;
   MENTAL-ILLNESS; INFLAMMATION; POPULATION; OBESITY; ASSOCIATION; DISEASE;
   ABNORMALITIES
AB Background Depressive and anxiety disorders are associated with shorter leukocyte telomere length (LTL), an indicator of cellular aging. It is, however, unknown which pathways underlie this association. This study examined the extent to which lifestyle factors and physiological changes such as inflammatory or metabolic alterations mediate the relationship.
   Method We applied mediation analysis techniques to data from 2750 participants of the Netherlands Study of Depression and Anxiety. LTL was assessed using quantitative polymerase chain reaction. Independent variables were current depressive (30-item Inventory of Depressive Symptoms - Self Report) and anxiety (21-item Beck's Anxiety Inventory) symptoms and presence of a depressive or anxiety disorder diagnosis based on DSM-IV; mediator variables included physiological stress systems, metabolic syndrome components and lifestyle factors.
   Results Short LTL was associated with higher symptom severity (B = -2.4, p = 0.002) and current psychiatric diagnosis (B = -63.3, p = 0.024). C-reactive protein, interleukin-6, waist circumference, triglycerides, high-density lipoprotein cholesterol and cigarette smoking were significant mediators in the relationship between psychopathology and LTL. When all significant mediators were included in one model, the effect sizes of the relationships between LTL and symptom severity and current diagnosis were reduced by 36.7 and 32.7%, respectively, and the remaining direct effects were no longer significant.
   Conclusions Pro-inflammatory cytokines, metabolic alterations and cigarette smoking are important mediators of the association between depressive and anxiety disorders and LTL. This calls for future research on intervention programs that take into account lifestyle changes in mental health care settings.
C1 [Revesz, D.; Verhoeven, J. E.] Vrije Univ Amsterdam, Med Ctr, Dept Psychiat, AJ Ernststr 1187, NL-1081 HL Amsterdam, Netherlands.
   Vrije Univ Amsterdam, Med Ctr, EMGO Inst Hlth & Care Res, AJ Ernststr 1187, NL-1081 HL Amsterdam, Netherlands.
C3 Vrije Universiteit Amsterdam; Vrije Universiteit Amsterdam
RP Révész, D; Verhoeven, JE (corresponding author), Vrije Univ Amsterdam, Med Ctr, Dept Psychiat, AJ Ernststr 1187, NL-1081 HL Amsterdam, Netherlands.
EM D.Revesz@vumc.nl; J.Verhoeven@ggzingeest.nl
RI Penninx, Brenda/S-7627-2017
OI Milaneschi, Yuri/0000-0002-3697-6617
FU NWO-VICI grant [91811602]; Geestkracht program of the Netherlands
   Organization for Health Research and Development (ZonMW) [10-000-1002]
FX The work of D.R., J.E.V. and B.W.J.H.P. and telomere length assaying was
   supported through a NWO-VICI grant (number 91811602). The infrastructure
   for the NESDA is funded through the Geestkracht program of the
   Netherlands Organization for Health Research and Development (ZonMW,
   grant number 10-000-1002).
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NR 74
TC 32
Z9 32
U1 0
U2 21
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
SN 0033-2917
EI 1469-8978
J9 PSYCHOL MED
JI Psychol. Med.
PD AUG
PY 2016
VL 46
IS 11
BP 2337
EP 2349
DI 10.1017/S0033291716000891
PG 13
WC Psychology, Clinical; Psychiatry; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA DT1FZ
UT WOS:000381228400009
PM 27266474
DA 2025-06-11
ER

PT J
AU Das, A
AF Das, Aniruddha
TI Depression, Inflammation, and Physiological Risk in Late Life: A
   National Longitudinal Study
SO BIODEMOGRAPHY AND SOCIAL BIOLOGY
LA English
DT Article
ID C-REACTIVE PROTEIN; MARGINAL STRUCTURAL MODELS; PITUITARY-ADRENAL AXIS;
   LOW-GRADE INFLAMMATION; METABOLIC SYNDROME; CARDIOVASCULAR-DISEASE;
   SOCIAL-LIFE; POSTTRAUMATIC-STRESS; MAJOR DEPRESSION; BLOOD-PRESSURE
AB This nationally representative study queried effects of community dwelling older adults' depression and inflammation at baseline on over-time changes in surrogate markers of their cardiometabolic risk. Data were from the 2005-2006 and 2010-2011 waves of the U.S. National Social Life, Health, and Aging Project. Inflammation was indicated by C-reactive protein and depression by the CES-D scale. Cardiometabolic markers included hemoglobin A1c and systolic BP. Lagged dependent variable models were used to examine effects. In none of the models did Wave 1 depression predict residual change in cardiometabolic states (i.e., Wave 2 values net of Wave 1). In contrast, men's baseline C-reactive protein predicted their Wave 2 hemoglobin A1c (Coeff.=0.02, p<.05) as well as their systolic BP (Coeff.=3.22, p<.05). No such effects were found among women. Contrary to a growing clinical literature, depression may not increase cardiometabolic risk among older adults on average. Moderators that may interact with depression to yield such effects in delimited samples remain to be identified. Inflammation, in contrast, does seem linked to increase in physiological riskbut only among men, not women. Clinical research is needed to identify biological factors responsible for this sex difference.
C1 [Das, Aniruddha] McGill Univ, Dept Sociol, Room 712,Leacock Bldg,855 Sherbrooke St West, Montreal, PQ H3A 2T7, Canada.
C3 McGill University
RP Das, A (corresponding author), McGill Univ, Dept Sociol, Room 712,Leacock Bldg,855 Sherbrooke St West, Montreal, PQ H3A 2T7, Canada.
EM aniruddha.das@mcgill.ca
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NR 93
TC 2
Z9 2
U1 0
U2 3
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 1948-5565
EI 1948-5573
J9 BIODEMOGR SOC BIOL
JI Biodemography Soc. Biol.
PY 2017
VL 63
IS 2
BP 131
EP 147
DI 10.1080/19485565.2017.1308245
PG 17
WC Demography; Social Sciences, Biomedical; Sociology
WE Social Science Citation Index (SSCI)
SC Demography; Biomedical Social Sciences; Sociology
GA EV4MP
UT WOS:000401734900004
PM 28521620
DA 2025-06-11
ER

PT B
AU Tsatsoulis, A
   Fountoulakis, S
AF Tsatsoulis, Agathocles
   Fountoulakis, Stelios
BE Chrousos, GP
   Tsigos, C
TI The protective role of exercise on stress system dysregulation and
   comorbidities
SO STRESS, OBESITY, AND METABOLIC SYNDROME
SE Annals of the New York Academy of Sciences-Series
LA English
DT Article; Proceedings Paper
CT Bjorntorp Symposium on Stress, Obesity, and Metabolic Syndrome
CY APR 09-10, 2005
CL Athens, GREECE
SP Roche Hellas, Abbott Hellas, Pfizer Hellas, Sanofi Aventis Hellas, GlaxoSmithKline Hellas
DE exercise; physical activity; stress; allostasis; metabolic syndrome;
   insulin resistance
ID LIFE-STYLE INTERVENTION; PHYSICAL-EXERCISE; SKELETAL-MUSCLE; INSULIN
   SENSITIVITY; METABOLIC SYNDROME; ADIPOSE-TISSUE; MESSENGER-RNA;
   EXPRESSION; PREVENTION; DEPRESSION
AB The human body, when under threat, elicits a set of neuroendocrine responses, including an increased secretion of glucocorticoids (GCs) and catecholamines from the adrenal gland and the activation of the sympathetic nervous system. These hormonal secretions allow a "fight or flight" response by mobilizing endogenous substrate and inducing a state of insulin resistance in the liver and skeletal muscles. Although the stress response was essential in ancient times to survive physical aggression, this threat has disappeared in our industrialized societies. However, in today's environment, the same stress responses can be elicited by emotional stimuli or professional and social stress. Such psychological stress may be protracted and unrelated to an increased metabolic demand. Thus, the energy mobilized is not used but is stored in visceral fat depots by the combined action of hypercortisolism and hyperinsulinemia. In addition, chronic activation of the stress system causes suppression of the gonadal, growth hormone (GH), and thyroid axes. These metabolic disturbances, in concert, lead to the clinical expression of a number of comorbidities including central obesity, hypertension, dyslipidemia, and endothelial dysfunction, all components of the metabolic syndrome and cardiometabolic risk factors. Moreover, chronic stress has deleterious effects on the brain and, in particular, affects hippocampal structure and function leading to cognitive and mood disturbances. Importantly, this stress-induced clinical phenotype is likely to be exaggerated in the presence of physical inactivity, resulting in a "stress-induced/exercise deficient" phenotype. Assuming that the stress response is a neuroendocrine mechanism that occurs in anticipation of physical action, then physical activity should be the natural means to prevent the consequences of stress. Indeed, accumulating evidence documents the beneficial effects of regular exercise in preventing or ameliorating the metabolic and psychological comorbidities induced by chronic stress. These benefits are thought to derive from a central effect of exercise to reduce the sensitivity to stress and also peripheral actions influencing metabolic functions and, in particular, insulin sensitivity and the partitioning of fuels toward oxidation rather than storage. It is concluded that chronic psychosocial stress, in the presence of physical inactivity, is likely to contribute to the epidemic of cardiometabolic and emotional disease of our current society. The way to prevent and combat this burden is by regular exercise.
C1 Univ Ioannina, Dept Endocrinol, GR-45110 Ioannina, Greece.
C3 University of Ioannina
RP Tsatsoulis, A (corresponding author), Univ Ioannina, Dept Endocrinol, GR-45110 Ioannina, Greece.
EM atsatsou@uoi.gr
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   [No title captured]
NR 90
TC 177
Z9 216
U1 2
U2 31
PU BLACKWELL SCIENCE PUBL
PI OXFORD
PA OSNEY MEAD, OXFORD OX2 0EL, ENGLAND
BN 978-1-57331-625-5
J9 ANN NY ACAD SCI
JI Ann.NY Acad.Sci.
PY 2006
VL 1083
BP 196
EP 213
DI 10.1196/annals.1367.020
PG 18
WC Endocrinology & Metabolism; Multidisciplinary Sciences
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Science & Technology - Other Topics
GA BFR90
UT WOS:000244102900014
PM 17148741
DA 2025-06-11
ER

PT J
AU Marquez, DX
   Bustamante, EE
   Kozey-Keadle, S
   Kraemer, J
   Carrion, L
AF Marquez, David X.
   Bustamante, Eduardo E.
   Kozey-Keadle, Sarah
   Kraemer, Jennifer
   Carrion, Lraida
TI Physical Activity and Psychosocial and Mental Health of Older Caregivers
   and Non-Caregivers
SO GERIATRIC NURSING
LA English
DT Article
ID METABOLIC SYNDROME; FAMILY CAREGIVERS; ACTIVITY SCALE; SELF-EFFICACY;
   ELDERLY PASE; EXERCISE; INTERVENTION; DEMENTIA; ADULTS; MAINTENANCE
AB Few studies have been conducted on physical activity (PA) in older caregivers, a population at risk for mental and physical decline. To assess and compare PA, PA preferences, psychosocial determinants of PA, and mental health indicators between older non-exercising caregivers and non-caregivers. Caregivers (N = 24) and non-caregivers (N = 48) completed questionnaires and wore an accelerometer for 7 consecutive days. Few significant differences were noted in objectively measured or subjectively reported PA between caregivers and non-caregivers. Non-caregivers reported greater social support to exercise from family members. Caregivers reported significantly greater anxiety, depression, stress, and negative health symptoms. Caregivers were significantly more likely to prefer exercise in 10-min bouts. Caregivers are in need of interventions to increase PA and health. Efforts to help caregivers participate in multiple shorter bouts of exercise during the day could be more effective than recommending one continuous 30-minute bout. (Geriatr Nurs 2012;33:358-365)
C1 [Marquez, David X.; Bustamante, Eduardo E.] Univ Illinois, Dept Kinesiol & Nutr, Chicago, IL 60680 USA.
   [Kozey-Keadle, Sarah; Kraemer, Jennifer] Univ Massachusetts, Dept Kinesiol, Amherst, MA USA.
   [Carrion, Lraida] Univ S Florida, Sch Social Work, Tampa, FL USA.
C3 University of Illinois System; University of Illinois Chicago;
   University of Illinois Chicago Hospital; University of Massachusetts
   System; University of Massachusetts Amherst; State University System of
   Florida; University of South Florida
RP Marquez, DX (corresponding author), Univ Illinois, Dept Kinesiol & Nutr, Chicago, IL 60680 USA.
OI Bustamante, Eduardo Esteban/0000-0002-5977-4145; Carrion,
   Iraida/0000-0003-4076-6644; Keadle, Sarah/0000-0002-9569-9306
FU Healy/Faculty Research Grant, University of Massachusetts, Amherst
FX Funding for this study was provided by a Healy/Faculty Research Grant,
   University of Massachusetts, Amherst. Thanks are extended to Richard J.
   Doyle, MD, PhD, for his assistance with the manuscript.
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NR 50
TC 35
Z9 43
U1 1
U2 36
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0197-4572
EI 1528-3984
J9 GERIATR NURS
JI Geriatr. Nurs.
PD SEP-OCT
PY 2012
VL 33
IS 5
BP 358
EP 365
DI 10.1016/j.gerinurse.2012.03.003
PG 8
WC Geriatrics & Gerontology; Gerontology; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Nursing
GA 030GH
UT WOS:000310558300004
PM 22595335
DA 2025-06-11
ER

PT J
AU Härdfeldt, J
   Cariello, M
   Simonelli, S
   Ossoli, A
   Scialpi, N
   Piglionica, M
   Pasculli, E
   Noia, A
   Berardi, E
   Suppressa, P
   Piazzolla, G
   Sabbà, C
   Calabresi, L
   Moschetta, A
AF Hardfeldt, Jennifer
   Cariello, Marica
   Simonelli, Sara
   Ossoli, Alice
   Scialpi, Natasha
   Piglionica, Marilidia
   Pasculli, Emanuela
   Noia, Alessia
   Berardi, Elsa
   Suppressa, Patrizia
   Piazzolla, Giuseppina
   Sabba, Carlo
   Calabresi, Laura
   Moschetta, Antonio
TI Abdominal obesity negatively influences key metrics of reverse
   cholesterol transport
SO BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
LA English
DT Article
DE Reverse cholesterol transport; HDL; LCAT; Inflammation; Abdominal
   obesity; Oxidative stress
ID HIGH-DENSITY-LIPOPROTEIN; GLYCATION END-PRODUCTS; METABOLIC SYNDROME;
   EFFLUX CAPACITY; A-I; PRE-BETA; CARDIOVASCULAR-DISEASE; OXIDATIVE
   STRESS; HDL; LECITHIN
AB Cardiometabolic risk factors increase the risk of atherosclerotic cardiovascular disease (ASCVD), but whether these metabolic anomalies affect the anti-atherogenic function of reverse cholesterol transport (RCT) is not yet clearly known. The present study aimed to delineate if the function and maturation of high density lipoprotein (HDL) particles cross-sectionally associate with surrogate markers of ASCVD in a population comprising of different degree of cardiometabolic risk. We enrolled 131 subjects and characterized cardiometabolic risk based on the IDF criteria's for metabolic syndrome (MS). In this population, cholesterol efflux capacity (CEC), Lecithin-cholesterol acyltransferase (LCAT) and ApoA-1 glycation was associated with waist circumference, abdominal visceral fat (VFA) and abdominal subcutaneous fat. In multivariate analyses, VFA was identified as a critical contributor for low CEC and LCAT. When stratified into groups based on the presence of cardiometabolic risk factors, we found a prominent reduction in CEC and LCAT as a function of the progressive increase of cardiometabolic risk from 0-2, 0-3 to 0-4/5, whereas an increase in Pre-beta-HDL and ApoA-1 glycation was observed between the lowest and highest risk groups. These findings confirm the connection between MS and its predisposing conditions to an impairment of atheroprotective efflux-promoting function of HDLs. Furthermore, we have identified the bona fide pathogenically contribution of abdominal obesity to profound alterations of key metrics of RCT.
C1 [Hardfeldt, Jennifer; Cariello, Marica; Scialpi, Natasha; Piglionica, Marilidia; Pasculli, Emanuela; Noia, Alessia; Berardi, Elsa; Suppressa, Patrizia; Piazzolla, Giuseppina; Sabba, Carlo; Moschetta, Antonio] Aldo Moro Univ Bari, Dept Interdisciplinary Med, Piazza Giulio Cesare 11, I-70124 Bari, Italy.
   [Hardfeldt, Jennifer; Piglionica, Marilidia; Moschetta, Antonio] Natl Inst Biostruct & Biosyst, INBB, Viale Medaglie dOro 305, I-00136 Rome, Italy.
   [Hardfeldt, Jennifer] Karolinska Univ Hosp Huddinge, Metab Unit, Dept Med, Karolinska Inst, S-14186 Stockholm, Sweden.
   [Simonelli, Sara; Ossoli, Alice; Calabresi, Laura] Univ Milan, Ctr E Grossi Paoletti, Dept Pharmacol & Biomol Sci, Via Balzaretti 9, I-20133 Milan, Italy.
   [Moschetta, Antonio] IRCCS Ist Tumori Giovanni Paolo II, Natl Canc Res Ctr, Bari, Italy.
C3 Universita degli Studi di Bari Aldo Moro; Karolinska Institutet;
   Karolinska University Hospital; University of Milan; IRCCS Istituto
   Tumori Bari Giovanni Paolo II
RP Moschetta, A (corresponding author), Univ Bari Aldo Moro, Clin Med Cesare Frugoni, Dept Interdisciplinary Med, Piazza Giulio Cesare 11, I-70124 Bari, Italy.
EM antonio.moschetta@uniba.it
RI Cariello, Marica/K-4064-2018; Piazzolla, Giuseppina/JEO-7179-2023;
   Moschetta, Antonio/K-6211-2016; Ossoli, Alice/K-5917-2016
OI Ossoli, Alice/0000-0002-9902-252X; Hardfeldt,
   Jennifer/0000-0002-6190-7365
FU MIUR [PRIN 2017J3E2W2_002]; JPI-EU FATMAL; Interreg V-A Greece-Italy
   2014-2020 [MIS 5003627]; NR-NET FP7 Marie Curie ITN
FX This work was supported by: MIUR DPRIN 2017J3E2W2_002 to AM, JPI-EU
   FATMAL to AM, Interreg V-A Greece-Italy 2014-2020 MIS 5003627 to AM,
   NR-NET FP7 Marie Curie ITN to AM. We thank the Physicians and Nurses of
   the Unit`a Operativa Complessa Universitaria di Medicina Interna "Cesare
   Frugoni" of the Azienda Ospedaliero-Universitaria Policlinico di Bari
   for their help and support during the study.
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NR 63
TC 8
Z9 9
U1 0
U2 8
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1388-1981
EI 1879-2618
J9 BBA-MOL CELL BIOL L
JI Biochim. Biophys. Acta Mol. Cell Biol. Lipids
PD FEB
PY 2022
VL 1867
IS 2
AR 159087
DI 10.1016/j.bbalip.2021.159087
EA DEC 2021
PG 11
WC Biochemistry & Molecular Biology; Biophysics; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Cell Biology
GA XM8IM
UT WOS:000729063500005
PM 34813947
DA 2025-06-11
ER

PT J
AU Lyzwinski, LN
   Elgendi, M
   Menon, C
AF Lyzwinski, Lynnette Nathalie
   Elgendi, Mohamed
   Menon, Carlo
TI Conversational Agents and Avatars for Cardiometabolic Risk Factors and
   Lifestyle-Related Behaviors: Scoping Review
SO JMIR MHEALTH AND UHEALTH
LA English
DT Review
DE chatbots; avatars; conversational coach; diet; physical activity;
   cardiovascular disease; hypertension; cardiometabolic; behavior; change;
   hypertension diabetes; metabolic syndrome; mobile phone; lifestyle
   -related weight interventions; Dietary modifications
ID PHYSICAL-ACTIVITY; WEIGHT-LOSS; GOLD STANDARD; VIRTUAL WORLD;
   MANAGEMENT; STRESS; SELF; INTERVENTION; HEALTH; HYPERTENSION
AB Background: In recent years, there has been a rise in the use of conversational agents for lifestyle medicine, in particular for weight-related behaviors and cardiometabolic risk factors. Little is known about the effectiveness and acceptability of and engagement with conversational and virtual agents as well as the applicability of these agents for metabolic syndrome risk factors such as an unhealthy dietary intake, physical inactivity, diabetes, and hypertension. Objective: This review aimed to get a greater understanding of the virtual agents that have been developed for cardiometabolic risk factors and to review their effectiveness.Methods: A systematic review of PubMed and MEDLINE was conducted to review conversational agents for cardiometabolic risk factors, including chatbots and embodied avatars.Results: A total of 50 studies were identified. Overall, chatbots and avatars appear to have the potential to improve weight-related behaviors such as dietary intake and physical activity. There were limited studies on hypertension and diabetes. Patients seemed interested in using chatbots and avatars for modifying cardiometabolic risk factors, and adherence was acceptable across the studies, except for studies of virtual agents for diabetes. However, there is a need for randomized controlled trials to confirm this finding. As there were only a few clinical trials, more research is needed to confirm whether conversational coaches may assist with cardiovascular disease and diabetes, and physical activity. Conclusions: Conversational coaches may regulate cardiometabolic risk factors; however, quality trials are needed to expand the evidence base. A future chatbot could be tailored to metabolic syndrome specifically, targeting all the areas covered in the literature, which would be novel.
C1 [Lyzwinski, Lynnette Nathalie; Menon, Carlo] Simon Fraser Univ, Sch Mechatron Syst Engn & Engn Sci, Menrva Res Grp, Metro Vancouver, BC, Canada.
   [Lyzwinski, Lynnette Nathalie] Simon Fraser Univ, Fac Hlth Sci, Burnaby, BC, Canada.
   [Elgendi, Mohamed; Menon, Carlo] Swiss Fed Inst Technol, Dept Hlth Sci & Technol, Biomed & Mobile Hlth Technol Lab, Zurich, Switzerland.
   [Lyzwinski, Lynnette Nathalie] Simon Fraser Univ, Sch Mechatron Syst Engn & Engn Sci, Menrva Res Grp, 250-13450 102 Ave, Metro Vancouver, BC V3T 0A3, Canada.
C3 Simon Fraser University; Simon Fraser University; Swiss Federal
   Institutes of Technology Domain; ETH Zurich; Simon Fraser University
RP Lyzwinski, LN (corresponding author), Simon Fraser Univ, Sch Mechatron Syst Engn & Engn Sci, Menrva Res Grp, 250-13450 102 Ave, Metro Vancouver, BC V3T 0A3, Canada.
EM lnl2@sfu.ca
RI Menon, Carlo/AAL-3158-2020; Elgendi, Mohamed/I-8596-2016
OI Elgendi, Mohamed (Moe)/0000-0003-1831-0202; Menon,
   Carlo/0000-0002-2309-9977
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NR 93
TC 6
Z9 6
U1 4
U2 9
PU JMIR PUBLICATIONS, INC
PI TORONTO
PA 130 QUEENS QUAY East, Unit 1100, TORONTO, ON M5A 0P6, CANADA
SN 2291-5222
J9 JMIR MHEALTH UHEALTH
JI JMIR mHealth uHealth
PY 2023
VL 11
AR e39649
DI 10.2196/39649
PG 21
WC Health Care Sciences & Services; Medical Informatics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Health Care Sciences & Services; Medical Informatics
GA K9WP7
UT WOS:001019867500001
PM 37227765
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Penninx, BWJH
   Milaneschi, Y
   Lamers, F
   Vogelzangs, N
AF Penninx, Brenda W. J. H.
   Milaneschi, Yuri
   Lamers, Femke
   Vogelzangs, Nicole
TI Understanding the somatic consequences of depression: biological
   mechanisms and the role of depression symptom profile
SO BMC MEDICINE
LA English
DT Review
DE Depression; Metabolic syndrome; Inflammation; Cortisol; Autonomic Tone;
   Cardiovascular; Obesity; Symptom profile; Treatment
ID CORONARY-HEART-DISEASE; C-REACTIVE PROTEIN; PRO-INFLAMMATORY CYTOKINES;
   CARDIAC VAGAL CONTROL; METABOLIC SYNDROME; MAJOR DEPRESSION;
   RATE-VARIABILITY; TREATMENT RESPONSE; HPA AXIS; PROINFLAMMATORY
   CYTOKINES
AB Depression is the most common psychiatric disorder worldwide. The burden of disease for depression goes beyond functioning and quality of life and extends to somatic health. Depression has been shown to subsequently increase the risk of, for example, cardiovascular, stroke, diabetes and obesity morbidity. These somatic consequences could partly be due to metabolic, immuno-inflammatory, autonomic and hypothalamic-pituitary-adrenal (HPA)-axis dysregulations which have been suggested to be more often present among depressed patients. Evidence linking depression to metabolic syndrome abnormalities indicates that depression is especially associated with its obesity-related components (for example, abdominal obesity and dyslipidemia). In addition, systemic inflammation and hyperactivity of the HPA-axis have been consistently observed among depressed patients. Slightly less consistent observations are for autonomic dysregulation among depressed patients. The heterogeneity of the depression concept seems to play a differentiating role: metabolic syndrome and inflammation up-regulations appear more specific to the atypical depression subtype, whereas hypercortisolemia appears more specific for melancholic depression. This review finishes with potential treatment implications for the downward spiral in which different depressive symptom profiles and biological dysregulations may impact on each other and interact with somatic health decline.
C1 [Penninx, Brenda W. J. H.; Milaneschi, Yuri; Vogelzangs, Nicole] Vrije Univ Amsterdam, Med Ctr, EMGO Inst & Neurosci Campus Amsterdam, Dept Psychiat, Amsterdam, Netherlands.
   [Lamers, Femke] NIMH, Genet Epidemiol Res Branch, Bethesda, MD 20892 USA.
   [Penninx, Brenda W. J. H.] Vrije Univ Amsterdam, Med Ctr, Dept Psychiat, NL-1081 HL Amsterdam, Netherlands.
   [Penninx, Brenda W. J. H.] GGZinGeest, NL-1081 HL Amsterdam, Netherlands.
C3 Vrije Universiteit Amsterdam; National Institutes of Health (NIH) - USA;
   NIH National Institute of Mental Health (NIMH); Vrije Universiteit
   Amsterdam
RP Penninx, BWJH (corresponding author), Vrije Univ Amsterdam, Med Ctr, EMGO Inst & Neurosci Campus Amsterdam, Dept Psychiat, Amsterdam, Netherlands.
EM b.penninx@vumc.nl
RI Penninx, Brenda/S-7627-2017; Lamers, Femke/G-5161-2012
OI Milaneschi, Yuri/0000-0002-3697-6617; Lamers, Femke/0000-0003-4344-5766
FU VICI grant (NWO) [91811602]; Intramural Research Training Award from the
   National Institute of Mental Health; VU University Medical Center EMGO
   Institute for Health and Care Research
FX Penninx was supported through a VICI grant (NWO grant 91811602), Lamers
   was supported through an Intramural Research Training Award from the
   National Institute of Mental Health, and Vogelzangs was supported
   through a fellowship from the VU University Medical Center EMGO
   Institute for Health and Care Research.
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NR 157
TC 597
Z9 644
U1 7
U2 206
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1741-7015
J9 BMC MED
JI BMC Med.
PD MAY 15
PY 2013
VL 11
AR 129
DI 10.1186/1741-7015-11-129
PG 14
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 149CD
UT WOS:000319294700001
PM 23672628
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Bystritsky, A
   Danial, J
   Kronemyer, D
AF Bystritsky, Alexander
   Danial, Jessica
   Kronemyer, David
TI Interactions Between Diabetes and Anxiety and Depression Implications
   for Treatment
SO ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA
LA English
DT Article
DE Anxiety; Cognitive behavioral therapy; Cognitive restructuring;
   Depression; Diabetes
ID COGNITIVE-BEHAVIORAL THERAPY; TRANSCRANIAL MAGNETIC STIMULATION;
   TREATMENT-RESISTANT DEPRESSION; ATYPICAL ANTIPSYCHOTICS; COMORBID
   DEPRESSION; METABOLIC SYNDROME; COLLABORATIVE CARE; GLUCOSE-METABOLISM;
   GLYCEMIC CONTROL; BLOOD-GLUCOSE
AB Anxiety or depression may be a risk factor for the development of diabetes. This relationship may occur through a combination of genetic predispositions; epigenetic contingencies; exacerbating conditions such as metabolic syndrome (a precursor to diabetes); and other serious medical conditions. Medications used to treat anxiety and depression have significant side effects, such as weight gain, further increasing the possibility of developing diabetes. These components combine, interact, and reassemble to create a precarious system for persons with, or predisposed to, diabetes. Clinicians must be aware of these interrelationships to adequately treat the disease.
C1 [Bystritsky, Alexander; Kronemyer, David] Univ Calif Los Angeles, Dept Psychiat & Biobehav Sci, Semel Inst Neurosci & Human Behav, David Geffen Sch Med, Los Angeles, CA 90095 USA.
   [Danial, Jessica] Alliant Int Univ, Calif Sch Profess Psychol, Los Angeles, CA 91803 USA.
C3 University of California System; University of California Los Angeles;
   University of California Los Angeles Medical Center; David Geffen School
   of Medicine at UCLA; Alliant International University
RP Bystritsky, A (corresponding author), Univ Calif Los Angeles, Dept Psychiat & Biobehav Sci, Semel Inst Neurosci & Human Behav, David Geffen Sch Med, 300 UCLA Med Plaza,Room 2330, Los Angeles, CA 90095 USA.
EM abystritsky@mednet.ucla.edu
FU Gerald J. and Dorothy R. Friedman New York Foundation for Medical
   Research
FX Gerald J. and Dorothy R. Friedman New York Foundation for Medical
   Research.
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NR 108
TC 26
Z9 29
U1 1
U2 28
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 0889-8529
EI 1558-4410
J9 ENDOCRIN METAB CLIN
JI Endocrinol. Metabol. Clin. North Amer.
PD MAR
PY 2014
VL 43
IS 1
BP 269
EP +
DI 10.1016/j.ecl.2013.10.001
PG 16
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism
GA AD8WW
UT WOS:000333547400016
PM 24582102
DA 2025-06-11
ER

PT J
AU Wu, SH
   Fisher-Hoch, SP
   Reininger, BM
   McCormick, JB
AF Wu, Shenghui
   Fisher-Hoch, Susan P.
   Reininger, Belinda M.
   McCormick, Joseph B.
TI Association Between Fruit and Vegetable Intake and Symptoms of Mental
   Health Conditions in Mexican Americans
SO HEALTH PSYCHOLOGY
LA English
DT Article
DE fruit; vegetable; cognitive impairment; dementia; anxiety
ID DOSE-RESPONSE METAANALYSIS; METABOLIC SYNDROME; COGNITIVE IMPAIRMENT;
   PROSPECTIVE COHORT; PHYSICAL-ACTIVITY; RISK-FACTOR; DEPRESSION;
   CONSUMPTION; DISORDERS; ANXIETY
AB Objective: No studies so far have shown the effect of fruit and vegetable intake on mental disorders in Mexican Americans, for whom mental illness is an important health issue. This study measured the association of fruit and vegetable intake with the symptoms of cognitive impairment, the indication of increased risk of dementia, anxiety, and depression in Mexican Americans. Method: Participants were drawn from the Cameron County Hispanic Cohort (N = 3,943), a randomly selected Mexican American cohort in Texas on the United States-Mexico border. Consumption of fruit and vegetables and symptoms of four mental disorders were assessed using reliable and validated instruments. Results: Among 2,702 participants (mean age = 50 years, 34% male) with available data. 213 had cognitive impairment, 61 had the indication of increased risk of dementia, 626 had depression, 196 had anxiety. and 787 (29.13%) had mental disorders (i.e., any symptoms of the above four disorders). Participants who met recommendations of 5 or more servings of fruits and vegetables per day were less likely to have anxiety (OR = 0.22, 95% CI [0.08, 0.65], cognitive impairment (OR = 0.16, 95% CI [0.05, 0.461), and indication of increased risk of dementia (OR = 0.16. 95% CI [0.03. 0.86]) compared with those who did not meet recommendations, after adjusting for covariates. Every portion increment of total fruit and vegetable intake was significantly associated with the reduced odds of mental disorders by 11% and the odds of cognitive impairment by 32%, with the adjustment of other covariates. No significant associations were found between fruit and vegetable intake and depression. Conclusion: Fruit and vegetable intake was inversely associated with symptoms of cognitive impairment, the indication of increased risk of dementia, and anxiety in Mexican Americans. Improving consumption of fruit and vegetables may be a convenient target for mental disorder-symptoms prevention and control among Mexican Americans, independent of other factors.
C1 [Wu, Shenghui] Univ Texas Hlth San Antonio, Dept Epidemiol & Biostat, Laredo Campus, San Antonio, TX USA.
   [Fisher-Hoch, Susan P.; McCormick, Joseph B.] Univ Texas Hlth Sci Ctr Houston, Div Epidemiol, Brownsville Campus,One West Univ Blvd, Brownsville, TX 78520 USA.
   [Reininger, Belinda M.] Univ Texas Hlth Sci Ctr Houston, Div Hlth Promot & Hlth Behav, Brownsville Campus, Brownsville, TX 77030 USA.
C3 University of Texas System; University of Texas Health Science Center at
   San Antonio; University of Texas System; University of Texas Health
   Science Center Houston; University of Texas System; University of Texas
   Health Science Center Houston
RP McCormick, JB (corresponding author), Univ Texas Hlth Sci Ctr Houston, Div Epidemiol, Brownsville Campus,One West Univ Blvd, Brownsville, TX 78520 USA.
EM joseph.b.mccormick@uth.tmc.edu
RI Wu, Shenghui/KBC-4561-2024
OI Wu, Shenghui/0000-0003-0505-086X; McCormick, Joseph/0000-0002-5844-8102
FU United States Department of Health and Human Services, National
   Institutes of Health (DHHS-NIH), National Center on Minority Health and
   Health Disparities [MD000170 P20]; NIH National Center for Advancing
   Translational Sciences Award [1U54RR023417-01]; DHHS Centers for Disease
   Control and Prevention Award [RO1 DP000210-01]
FX This work was supported by Grant MD000170 P20 funded from the United
   States Department of Health and Human Services, National Institutes of
   Health (DHHS-NIH), National Center on Minority Health and Health
   Disparities; NIH National Center for Advancing Translational Sciences
   Award 1U54RR023417-01; and the DHHS Centers for Disease Control and
   Prevention Award RO1 DP000210-01 for Research Resources. We thank our
   cohort team, particularly, Rocio Uribe (Brownsville), Becky Erazo
   (Laredo), Ariana Garza (Harlingen) and their teams, who recruited and
   documented the participants. We thank the Tu Salud Si Cuenta
   data-collection team, as they collected the fruit and vegetable measures
   in Brownsville. We also thank Marcela Morris and other laboratory staff
   for their contributions, and Christina Villarreal for administrative
   support. We thank Valley Baptist Medical Center, Brownsville, Texas for
   providing us space for our Center for Clinical and Translational Science
   Clinical Research Unit. We also thank the communities of Brownsville,
   Laredo, and Harlingen and the participants who so willingly participated
   in this study in their cities.
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NR 38
TC 26
Z9 28
U1 0
U2 13
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 0278-6133
EI 1930-7810
J9 HEALTH PSYCHOL
JI Health Psychol.
PD NOV
PY 2018
VL 37
IS 11
BP 1059
EP 1066
DI 10.1037/hea0000646
PG 8
WC Psychology, Clinical; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology
GA GW7PK
UT WOS:000447160600010
PM 30299120
OA Green Accepted, hybrid
DA 2025-06-11
ER

PT J
AU Hildreth, KL
   Grigsby, J
   Bryant, LL
   Wolfe, P
   Baxter, J
AF Hildreth, Kerry L.
   Grigsby, Jim
   Bryant, Lucinda L.
   Wolfe, Pamela
   Baxter, Judith
TI Cognitive decline and cardiometabolic risk among Hispanic and
   non-Hispanic white adults in the San Luis Valley Health and Aging Study
SO JOURNAL OF BEHAVIORAL MEDICINE
LA English
DT Article
DE Cognitive decline; Executive function; Cardiometabolic risk; Hispanic
ID MINI-MENTAL-STATE; OLDER MEXICAN-AMERICANS; IMPAIRED GLUCOSE-TOLERANCE;
   METABOLIC SYNDROME; ALZHEIMER-DISEASE; BLOOD-PRESSURE; LATE-LIFE;
   ETHNIC-DIFFERENCES; PHYSICAL-ACTIVITY; EXAMINATION MMSE
AB Cardiometabolic risk factors, including hypertension, dyslipidemia, central obesity, insulin resistance and diabetes are linked to cognitive impairment. The Hispanic population appears to be differentially affected by both cardiometabolic risk factors and cognitive impairment. We sought to determine whether ethnic differences in cognitive impairment in long-resident southwestern US elders was explained by the presence of cardiometabolic risk factors, and to explore patterns of cognitive decline over time. We performed a secondary analysis of data collected on 378 Hispanic and 409 non-Hispanic white adult participants in a longitudinal study of community-dwelling elderly in southern Colorado. Measures of cardiometabolic risk included waist circumference, blood pressure, diagnosis of diabetes, and random blood glucose. Cognitive measures included the Mini-Mental State Exam (MMSE) and the behavioral dyscontrol scale (a measure of executive cognitive function), at baseline and after an average of 22 months. Subjects were also administered the Center for Epidemiologic Studies Depression Scale, and the Coronary Artery Risk Development in Young Adults 1-Year Activity Recall. At baseline, Hispanic elders had a greater number of cardiometabolic risk factors and lower MMSE and behavioral dyscontrol scale scores than non-Hispanic whites. Hispanic ethnicity was associated with a greater likelihood of decline in general cognitive function, but not executive cognitive function, after adjusting for age and education. This differential decline was not explained by either individual or total number of baseline cardiometabolic risk factors, depression, or physical activity. A borderline increased risk of decline in general cognitive function was seen in sedentary individuals (P = 0.05).
C1 [Hildreth, Kerry L.] Univ Colorado, Sch Med, Div Geriatr Med, Aurora, CO 80045 USA.
   [Grigsby, Jim] Univ Colorado Denver, Dept Psychol, Aurora, CO USA.
   [Grigsby, Jim] Univ Colorado, Sch Med, Div Hlth Care Policy & Res, Aurora, CO 80045 USA.
   [Bryant, Lucinda L.; Baxter, Judith] Univ Colorado Denver, Colorado Sch Publ Hlth, Dept Community & Behav Hlth, Aurora, CO USA.
   [Bryant, Lucinda L.] Univ Colorado Denver, Colorado Sch Publ Hlth, Dept Hlth Syst Management & Policy, Aurora, CO USA.
   [Wolfe, Pamela] Univ Colorado Denver, Colorado Sch Publ Hlth, Colorado Biostat Consortium, Aurora, CO USA.
C3 University of Colorado System; University of Colorado Anschutz Medical
   Campus; Children's Hospital Colorado; University of Colorado System;
   University of Colorado Anschutz Medical Campus; University of Colorado
   System; University of Colorado Anschutz Medical Campus; Colorado School
   of Public Health; Children's Hospital Colorado; University of Colorado
   System; University of Colorado Anschutz Medical Campus; University of
   Colorado System; University of Colorado Anschutz Medical Campus;
   Children's Hospital Colorado; Colorado School of Public Health; Colorado
   School of Public Health; Children's Hospital Colorado; University of
   Colorado System; University of Colorado Anschutz Medical Campus
RP Hildreth, KL (corresponding author), Univ Colorado, Sch Med, Div Geriatr Med, Mail Stop B-179,12631 East 17th Ave, Aurora, CO 80045 USA.
EM kerry.hildreth@ucdenver.edu
RI Grigsby, Jim/JUV-6822-2023
OI Grigsby, Jim/0009-0008-1002-9807
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NR 69
TC 9
Z9 11
U1 0
U2 12
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0160-7715
EI 1573-3521
J9 J BEHAV MED
JI J. Behav. Med.
PD APR
PY 2014
VL 37
IS 2
BP 332
EP 342
DI 10.1007/s10865-013-9491-z
PG 11
WC Psychology, Clinical
WE Social Science Citation Index (SSCI)
SC Psychology
GA AC7EF
UT WOS:000332689300015
PM 23329423
DA 2025-06-11
ER

PT J
AU Carney, R
   Firth, J
AF Carney, Rebekah
   Firth, Joseph
TI Exercise interventions in child and adolescent mental health care: An
   overview of the evidence and recommendations for implementation
SO JCPP ADVANCES
LA English
DT Article
DE adolescence; comorbidity; early intervention; health; intervention
ID ULTRA-HIGH RISK; YOUNG-PEOPLE; PHYSICAL HEALTH; CARDIOMETABOLIC RISK;
   METABOLIC SYNDROME; PUBLIC-HEALTH; LIFE-STYLE; ILLNESS; METAANALYSIS;
   DEPRESSION
AB Background: The use of physical activity interventions in mental health care for adults has a large academic evidence base and numerous examples of real-world implementation. However, the use of physical activity within mental health care for children and young people (CYP) has received less attention to date.
   Methods: A narrative review was conducted to summarize the relevant literature in the area. Online databases were searched using terms synonymous with CYP, exercise, physical health, and mental health. Findings from existing systematic reviews, meta-analyses, meta-syntheses, and consensus statements were reviewed, and used alongside the authors' experience to inform clinical recommendations.
   Results: We first discuss the importance of applying physical health interventions in early stages of mental illness for CYP to prevent physical comorbidities and premature mortality in the long term. We then provide a brief summary of the current evidence of the benefits of exercise interventions in CYP with mental illness. We then present our top five recommendations on the implementation of exercise interventions within CYP mental health care.
   Conclusion: The key conclusions from this suggest there is an increasingly strong evidence base for the benefits of using physical activity interventions to improve, prevent, and manage physical and mental health outcomes in CYP with mental illness. However, more work needs to be done to improve the evidence base, refine its implementation into standard mental health care, and develop strategies for large-scale dissemination of such interventions across various care and cultural contexts.
C1 [Carney, Rebekah] Greater Manchester Mental Hlth NHS Fdn Trust, Youth Mental Hlth Res Unit, Rico House,Bury New Rd, Manchester M13 3BL, Lancs, England.
   [Carney, Rebekah; Firth, Joseph] Univ Manchester, Div Psychol & Mental Hlth, Manchester, Lancs, England.
   [Firth, Joseph] Western Sydney Univ, NICM Hlth Res Inst, Westmead, NSW, Australia.
C3 University of Manchester; Western Sydney University
RP Carney, R (corresponding author), Greater Manchester Mental Hlth NHS Fdn Trust, Youth Mental Hlth Res Unit, Rico House,Bury New Rd, Manchester M13 3BL, Lancs, England.
EM Rebekah.carney@gmmh.nhs.uk
RI Firth, Joseph/JOZ-1679-2023; Carney, Rebekah/AAO-5205-2021
OI Carney, Rebekah/0000-0002-2859-6825
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NR 51
TC 11
Z9 12
U1 4
U2 8
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2692-9384
J9 JCPP ADV
JI JCPP Adv.
PD DEC
PY 2021
VL 1
IS 4
AR e12031
DI 10.1002/jcv2.12031
PG 7
WC Psychology, Developmental; Psychiatry; Psychology
WE Emerging Sources Citation Index (ESCI)
SC Psychology; Psychiatry
GA D6M6K
UT WOS:001297307100002
PM 37431402
OA gold
DA 2025-06-11
ER

PT J
AU Stahl, SM
   Mignon, L
   Meyer, JM
AF Stahl, S. M.
   Mignon, L.
   Meyer, J. M.
TI Which comes first: atypical antipsychotic treatment or cardiometabolic
   risk?
SO ACTA PSYCHIATRICA SCANDINAVICA
LA English
DT Article
DE atypical antipsychotic; metabolic; cardiovascular; triglycerides;
   insulin resistance
ID INDUCED WEIGHT-GAIN; METABOLIC SYNDROME; INSULIN-SECRETION; BODY-MASS;
   RECEPTOR; OLANZAPINE; SCHIZOPHRENIA; RISPERIDONE; DYSLIPIDEMIA;
   ADOLESCENTS
AB To provide an overview for practicing clinicians on the pharmacological basis of cardiometabolic risk induced by antipsychotic drugs in patients with serious mental illness, to propose hypotheses to explain these risks and to give tips for managing cardiometabolic risk during antipsychotic treatment.
   A MEDLINE search using terms for atypical antipsychotics (including individual drug names), metabolic, cardiovascular, weight gain and insulin resistance, cross-referenced with schizophrenia was performed on articles published between 1990 and May 2008.
   Strong evidence exists for significant cardiometabolic risk differences among several antipsychotic agents. Histamine H1 and serotonin 5HT2C antagonism are associated with risk of weight gain, but receptor targets for dyslipidemia and insulin resistance have not yet been identified. Convincing data indicate that hypertriglyceridemia and insulin resistance may occur in the absence of weight gain with certain antipsychotics.
   Although lifestyle and genetics may contribute independent risks of cardiometabolic dysfunction in schizophrenia and other serious mental illness, antipsychotic treatment also represents an important contributor to risk of cardiometabolic dysfunction, particularly for certain drugs and for vulnerable patients. Mental health professionals must learn to recognize the clinical signposts indicating antipsychotic-related cardiometabolic problems to forestall progression to type II diabetes, cardiovascular events and premature death.
C1 [Stahl, S. M.; Meyer, J. M.] Univ Calif San Diego, Sch Med, Dept Psychiat, San Diego, CA 92103 USA.
   [Mignon, L.] Neurosci Educ Inst, Carlsbad, CA USA.
   [Meyer, J. M.] Vet Affairs San Diego Healthcare Syst, La Jolla, CA USA.
C3 University of California System; University of California San Diego; US
   Department of Veterans Affairs; Veterans Health Administration (VHA); VA
   San Diego Healthcare System
RP Stahl, SM (corresponding author), 1930 Palomar Point Way,Suite 103, Carlsbad, CA 92008 USA.
EM smstahl@neiglobal.com
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NR 48
TC 195
Z9 210
U1 0
U2 15
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0001-690X
EI 1600-0447
J9 ACTA PSYCHIAT SCAND
JI Acta Psychiatr. Scand.
PD MAR
PY 2009
VL 119
IS 3
BP 171
EP 179
DI 10.1111/j.1600-0447.2008.01334.x
PG 9
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 399UL
UT WOS:000262824700002
PM 19178394
OA Bronze
DA 2025-06-11
ER

PT J
AU Lee, LO
   Grimm, KJ
   Spiro, A
   Kubzansky, LD
AF Lee, Lewina O.
   Grimm, Kevin J.
   Spiro, Avron, III
   Kubzansky, Laura D.
TI Neuroticism, Worry, and Cardiometabolic Risk Trajectories: Findings From
   a 40-Year Study of Men
SO JOURNAL OF THE AMERICAN HEART ASSOCIATION
LA English
DT Article
DE anxiety; neuroticism; cardiometabolic risk; aging; prospective study
ID CORONARY-HEART-DISEASE; METABOLIC SYNDROME; PERSONALITY-TRAITS;
   ALLOSTATIC LOAD; ANXIETY; HEALTH; ASSOCIATION; MORTALITY; METAANALYSIS;
   DEPRESSION
AB Background Anxiety is linked to elevated risk of cardiometabolic disease onset, but the underlying mechanisms remain unclear. We examined the prospective association of 2 anxiety facets, neuroticism and worry, with cardiometabolic risk (CMR) trajectories for 4 decades. Methods and Results The sample comprised 1561 men from an ongoing adult male cohort. In 1975, healthy men (mean age, 53 years [SD, 8.4 years]) completed the Eysenck Personality Inventory-Short Form neuroticism scale and a Worries Scale. Seven CMR biomarkers were assessed every 3 to 5 years. The CMR score was the number of biomarkers categorized as high-risk based on established cut points or medication use. Using mixed effects regression, we modeled CMR trajectories over age and evaluated their associations with neuroticism and worry. Using Cox regression, we examined associations of neuroticism and worry with risk of having >= 6 CMR high-risk biomarkers through 2015. CMR increased at 0.8 markers per decade from age 33 to 65 years, at which point men had an average of 3.8 high-risk markers, followed by a slower increase of 0.5 markers per decade. Higher neuroticism (B=0.08; 95% CI, 0.02-0.15) and worry levels (B=0.07; 95% CI, 0.001-0.13) were associated with elevated CMR across time, and with 13% (95% CI, 1.03-1.23) and 10% (95% CI, 1.01-1.20) greater risks, respectively, of having >= 6 high-risk CMR markers, adjusting for potential confounders. Conclusions By middle adulthood, higher anxiety levels are associated with stable differences in CMR that are maintained into older ages. Anxious individuals may experience deteriorations in cardiometabolic health earlier in life and remain on a stable trajectory of heightened risk into older ages.
C1 [Lee, Lewina O.] VA Boston Healthcare Syst, Natl Ctr Posttraumat Stress Disorder, Boston, MA 02130 USA.
   [Lee, Lewina O.] Boston Univ, Sch Med, Dept Psychiat, Boston, MA USA.
   [Grimm, Kevin J.] Arizona State Univ, Dept Psychol, Tempe, AZ 85287 USA.
   [Spiro, Avron, III] VA Boston Healthcare Syst, Massachusetts Vet Epidemiol Res & Informat Ctr, Boston, MA USA.
   [Spiro, Avron, III] Boston Univ, Dept Epidemiol, Sch Publ Hlth, Boston, MA USA.
   [Kubzansky, Laura D.] Harvard TH Chan Sch Publ Hlth, Dept Social & Behav Sci, Boston, MA USA.
   [Kubzansky, Laura D.] Harvard TH Chan Sch Publ Hlth, Lee Kum Sheung Ctr Hlth & Happiness, Boston, MA USA.
C3 Harvard University; Harvard University Medical Affiliates; US Department
   of Veterans Affairs; Veterans Health Administration (VHA); VA Boston
   Healthcare System; Boston University; Arizona State University; Arizona
   State University-Tempe; Harvard University; Harvard University Medical
   Affiliates; US Department of Veterans Affairs; Veterans Health
   Administration (VHA); VA Boston Healthcare System; Boston University;
   Harvard University; Harvard T.H. Chan School of Public Health; Harvard
   University; Harvard T.H. Chan School of Public Health
RP Lee, LO (corresponding author), VA Boston Healthcare Syst, 150 South Huntington Ave,116B-4, Boston, MA 02130 USA.
EM lewina0@bu.edu
OI Lee, Lewina/0000-0002-1652-8198
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NR 52
TC 14
Z9 17
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
EI 2047-9980
J9 J AM HEART ASSOC
JI J. Am. Heart Assoc.
PD FEB 1
PY 2022
VL 11
IS 3
AR e022006
DI 10.1161/JAHA.121.022006
PG 22
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Cardiovascular System & Cardiology
GA YP9RB
UT WOS:000748956000002
PM 35072514
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Onat, A
   Can, G
AF Onat, Altan
   Can, Gunay
TI Enhanced Proinflammatory State and Autoimmune Activation: a Breakthrough
   to Understanding Chronic Diseases
SO CURRENT PHARMACEUTICAL DESIGN
LA English
DT Article
DE Autoimmune activation; coronary heart disease; type 2 diabetes;
   lipoprotein(a); metabolic syndrome; proinflammatory state
ID HIGH-DENSITY-LIPOPROTEIN; APOLIPOPROTEIN-A-I; CORONARY-HEART-DISEASE;
   METABOLIC SYNDROME; CARDIOVASCULAR-DISEASE; OXIDIZED PHOSPHOLIPIDS;
   INSULIN-RESISTANCE; DIABETES-MELLITUS; RISK-FACTORS; CHOLESTEROL LEVELS
AB Insight is provided herein into the novel mechanisms of cardiometabolic risk. Previous reports, including the epidemiological work of the Turkish Adult Risk Factor study, indicated that proinflammatory state and oxidative stress are crucial for evaluating cardiometabolic risk. Autoimmune pathways in the course of oxidative stress are major determinants of cardiorenal and metabolic risk. The latter encompasses metabolic syndrome, type 2 diabetes, coronary heart disease, and chronic kidney disease (CKD).
   Along with platelet-activating factor acetylhydrolase, creatinine, thyroid stimulating hormone, acylation-stimulating protein, asymmetric dimethylarginine, and serum lipoprotein[Lp](a) are triggers of systemic low-grade inflammation and enhanced autoimmune reactions. Related studies are analyzed in the current review.
   Lp(a) plays a crucial role by taking part in the immune activation, thereby accelerating the course of diabetes, CKD, and other chronic disorders. Populations prone to impaired glucose tolerance, and particularly peri- and postmenopausal women, are at high risk of developing related vascular complications.
C1 [Onat, Altan] Istanbul Univ, Cerrahpasa Med Sch, Dept Cardiol, Istanbul, Turkey.
   [Onat, Altan] Turkish Soc Cardiol, Istanbul, Turkey.
   [Can, Gunay] Istanbul Univ, Cerrahpasa Med Sch, Dept Publ Hlth, Istanbul, Turkey.
C3 Istanbul University - Cerrahpasa; Istanbul University; Turkish Heart
   Foundation; Istanbul University; Istanbul University - Cerrahpasa
RP Onat, A (corresponding author), Nisbetiye Cad 59-24, TR-34335 Istanbul, Turkey.
EM alt_onat@yahoo.com.tr
RI Can, Günay/AAB-1669-2020
FU The Turkish Society of Cardiology
FX The Turkish Society of Cardiology is gratefully acknowledged for its
   support to the Turkish Adult Risk Factor study.
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NR 98
TC 91
Z9 92
U1 0
U2 19
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1381-6128
EI 1873-4286
J9 CURR PHARM DESIGN
JI Curr. Pharm. Design
PD FEB
PY 2014
VL 20
IS 4
BP 575
EP 584
DI 10.2174/138161282004140213145551
PG 10
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA AE9DV
UT WOS:000334305800011
PM 23565630
DA 2025-06-11
ER

PT J
AU Al-Oubaidy, SA
   Awadh, SA
   Lafta, MA
AF Al-Oubaidy, Shaimaa A.
   Awadh, Sura A.
   Lafta, Mohammed Ali
TI Investigate the Effects of the A16V MnSOD SNPs on Insulin Resistant
   Index and Metabolic Profile Levels in Iraqi Metabolic Syndrome Patients
SO JOURNAL OF PHARMACEUTICAL NEGATIVE RESULTS
LA English
DT Article
DE Metabolic syndrome; A16V SNP; MnSOD; Insulin; FBG
ID GENE POLYMORPHISM V16A; STRESS-RESPONSE
AB Background: The metabolic syndrome (MS) is a group of clinical disorders that includes central and abdominal obesity, systemic hypertension, insulin resistance (T2DM), and atherogenic dyslipidemia. It is also known as syndrome X, insulin resistance syndrome, and Reaven syndrome. The current study was carried out to assess the effects of MnSOD A16V genetic polymorphism on MS incidence in the Iraqi population.
   Methods: This study included 50 patients with MS (27 male and 23 female) at range of age (22-59 Y) and 50 subjects as control group with matching in age and genders. Insulin levels INS (mu U/ml) were estimated by use of ELISA technique and insulin resistant index (IRI) was estimated by specific formula while FBG, TC, TG, LDL-C, and HDL-C (mg/dl) were performed by use spectrophotometric method. PCR-RFLP was done to investigation of the A16V MnSOD SNP.
   Results: The results show that the MS and CONT groups had significantly significant differences in INS (U/ml) and IRI (p-value 0.05). The results reveal statistical differences between MS and CONT genotypes AA and VV compared to AV genotypes.
   Conclusion: In the Iraqi population, the A16V MnSOD SNP plays a crucial role in the occurrence and progression of MS.
C1 [Al-Oubaidy, Shaimaa A.] Univ Babylon, Coll Med, Dept Human Anat & Histol, Hillah, Iraq.
   [Awadh, Sura A.] Al Mustaqbal Univ, Dept Anesthesia, Babylon, Iraq.
   [Lafta, Mohammed Ali] Minist Hlth, AL Kifel Gen Hosp, Baghdad, Iraq.
C3 University of Babylon; Al-Mustaqbal University College; Ministry of
   Health Iraq
RP Al-Oubaidy, SA (corresponding author), Univ Babylon, Coll Med, Dept Human Anat & Histol, Hillah, Iraq.
EM sura.abdailahalek@mustaqbal-college.edu.iq
OI Awadh, Dr. Sura/0000-0002-0620-3699
CR Abdou DM, 2021, EGYPTIAN J MED HUMAN, V22, DOI 10.1186/s43042-021-00139-y
   Bresciani G, 2013, FREE RADICAL RES, V47, P781, DOI 10.3109/10715762.2013.836275
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   Chen H, 2012, MOL CELL BIOCHEM, V363, P85, DOI 10.1007/s11010-011-1160-3
   Ginsberg Henry N, 2009, J Cardiometab Syndr, V4, P113, DOI 10.1111/j.1559-4572.2008.00044.x
   Grundy SM, CLIN MANAGEMENT
   Hosoki A, 2012, J RADIAT RES, V53, P58, DOI 10.1269/jrr.11034
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   Pourvali Katayoun, 2016, Avicenna Journal of Medical Biotechnology, V8, P48
NR 10
TC 3
Z9 3
U1 0
U2 0
PU RESEARCHTRENTZ ACAD PUBL EDUCATION SERVICES
PI Somerville
PA 240 Elm Street, 2nd & 3rd Floors, Somerville, MA, UNITED STATES
SN 0976-9234
EI 2229-7723
J9 J PHARM NEGAT RESULT
JI J. Pharm. Negat. Results
PY 2022
VL 13
IS 1
BP 95
EP 99
DI 10.47750/pnr.2022.13.01.017
PG 5
WC Pharmacology & Pharmacy
WE Emerging Sources Citation Index (ESCI)
SC Pharmacology & Pharmacy
GA 4I9IX
UT WOS:000850887100014
DA 2025-06-11
ER

PT J
AU Vaccarino, V
   Kondwani, KA
   Kelley, ME
   Murrah, NV
   Boyd, L
   Ahmed, Y
   Meng, YX
   Gibbons, GH
   Hooper, WC
   De Staercke, C
   Quyyumi, AA
AF Vaccarino, Viola
   Kondwani, Kofi A.
   Kelley, Mary E.
   Murrah, Nancy V.
   Boyd, Linda
   Ahmed, Yusuf
   Meng, Yuan X.
   Gibbons, Gary H.
   Hooper, W. Craig
   De Staercke, Christine
   Quyyumi, Arshed A.
TI Effect of Meditation on Endothelial Function in Black Americans With
   Metabolic Syndrome: A Randomized Trial
SO PSYCHOSOMATIC MEDICINE
LA English
DT Review
DE Endothelium; stress; metabolic syndrome; obesity
ID AMBULATORY BLOOD-PRESSURE; DENSITY-LIPOPROTEIN CHOLESTEROL;
   AFRICAN-AMERICAN; INSULIN-RESISTANCE; DEPRESSIVE SYMPTOMS;
   TRANSCENDENTAL-MEDITATION; ATHEROSCLEROSIS RISK; STRESS REDUCTION; WHITE
   ADULTS; VISCERAL FAT
AB Objectives: Psychological stress may play a role in metabolic syndrome. A consequence of metabolic syndrome is endothelial dysfunction, which is also influenced by psychological stress. We sought to compare the effect of consciously resting meditation (CRM), a sound based meditation, with a control intervention of health education (HE) on endothelial function in the setting of metabolic syndrome. Methods: Sixty-eight black Americans with metabolic syndrome risk factors (age, 30-65 years) were randomized to either CRM (n = 33) or HE (n = 35); interventions were matched for frequency and duration of sessions and lasted 12 months. Endothelial function was assessed by brachial artery flow-mediated dilation at baseline and at 6 and 12 months. Arterial elasticity, metabolic risk factors, and psychosocial and behavioral variables were secondary end points. Results: Although flow-mediated dilation improved in the CRM group for 12 months, this increase was not significantly higher than that in the HE group (p = .51 for the interaction between group and time). Non-endothelium-dependent dilation and arterial elasticity did not change in either group. Most metabolic syndrome risk factors showed beneficial trends in the CRM group only. A risk factor score counting the number of metabolic syndrome components decreased in the CRM group only (p = .049 for the interaction between treatment group and time). Conclusions: Among black Americans with metabolic syndrome risk factors, CRM, did not improve endothelial function significantly more than a control intervention of HE. CRM resulted in favorable trends in metabolic syndrome risk factors, which were examined as secondary outcomes.
C1 [Vaccarino, Viola; Murrah, Nancy V.] Emory Univ, Dept Epidemiol, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA.
   [Kelley, Mary E.] Emory Univ, Dept Biostat & Bioinformat, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA.
   [Vaccarino, Viola; Ahmed, Yusuf; Quyyumi, Arshed A.] Emory Univ, Sch Med, Dept Med, Div Cardiol, Atlanta, GA 30322 USA.
   [Kondwani, Kofi A.; Boyd, Linda; Meng, Yuan X.; Gibbons, Gary H.] Morehouse Sch Med, Cardiovasc Res Inst, Atlanta, GA 30310 USA.
   [Hooper, W. Craig; De Staercke, Christine] Ctr Dis Control & Prevent, Natl Birth Defects Ctr, Div Hereditary Blood Disorders, Atlanta, GA USA.
C3 Emory University; Rollins School Public Health; Emory University;
   Rollins School Public Health; Emory University; Morehouse School of
   Medicine; Centers for Disease Control & Prevention - USA
RP Vaccarino, V (corresponding author), Emory Univ, Dept Epidemiol, Rollins Sch Publ Hlth, 1518 Clifton Rd NE,Room 3011, Atlanta, GA 30322 USA.
EM viola.vaccarino@emory.edu
RI Meng, yuan/JRY-8417-2023; Vaccarino, Viola/AAW-5600-2020
OI Vaccarino, Laura Viola/0000-0002-9054-0654
FU National Institutes of Health (NIH)/National Heart, Lung, and Blood
   Institute [U01 HL079156, U01 HL79214]; NIH/National Center for Research
   Resources [M01-RR00039, 5P20RR11104]; NIH [K24HL077506]
FX This study was supported by funding from the National Institutes of
   Health (NIH)/National Heart, Lung, and Blood Institute U01 HL079156 and
   U01 HL79214; NIH/National Center for Research Resources Grant
   M01-RR00039 for the Emory General Clinical Research Center; NIH/National
   Center for Research Resources 5P20RR11104 for the Morehouse Clinical
   Research Center; and NIH K24HL077506.
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NR 58
TC 11
Z9 12
U1 0
U2 8
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0033-3174
EI 1534-7796
J9 PSYCHOSOM MED
JI Psychosom. Med.
PD JUL-AUG
PY 2013
VL 75
IS 6
BP 591
EP 599
DI 10.1097/PSY.0b013e31829ac4f4
PG 9
WC Psychiatry; Psychology; Psychology, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry; Psychology
GA 300MS
UT WOS:000330468600010
PM 23788695
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Ahmed, M
   Cerda, I
   Maloof, M
AF Ahmed, Minhal
   Cerda, Ivo
   Maloof, Molly
TI Breaking the vicious cycle: The interplay between loneliness, metabolic
   illness, and mental health
SO FRONTIERS IN PSYCHIATRY
LA English
DT Article
DE loneliness; social isolation; metabolic syndrome; mental health;
   depression; chronic stress; HPA axis; mitochondria
ID POPULATION-BASED SAMPLE; SOCIAL-ISOLATION; MITOCHONDRIAL DYSFUNCTION;
   PSYCHOLOGICAL STRESS; CHICAGO HEALTH; OLDER-PEOPLE; NETWORK; WELL;
   INTERVENTIONS; ASSOCIATIONS
AB Loneliness, or perceived social isolation, is a leading predictor of all-cause mortality and is increasingly considered a public health epidemic afflicting significant portions of the general population. Chronic loneliness is itself associated with two of the most pressing public health epidemics currently facing the globe: the rise of mental illness and metabolic health disorders. Here, we highlight the epidemiological associations between loneliness and mental and metabolic health disorders and argue that loneliness contributes to the etiology of these conditions by acting as a chronic stressor that leads to neuroendocrine dysregulation and downstream immunometabolic consequences that manifest in disease. Specifically, we describe how loneliness can lead to overactivation of the hypothalamic-pituitary-adrenal axis and ultimately cause mitochondrial dysfunction, which is implicated in mental and metabolic disease. These conditions can, in turn, lead to further social isolation and propel a vicious cycle of chronic illness. Finally, we outline interventions and policy recommendations that can reduce loneliness at both the individual and community levels. Given its role in the etiology of the most prevalent chronic diseases of our time, focusing resources on alleviating loneliness is a vitally important and cost-effective public health strategy.
C1 [Ahmed, Minhal; Cerda, Ivo] Harvard Med Sch, Boston, MA 02115 USA.
   [Maloof, Molly] Adamo Biosci Inc, Fernandina Beach, FL USA.
C3 Harvard University; Harvard Medical School
RP Ahmed, M; Cerda, I (corresponding author), Harvard Med Sch, Boston, MA 02115 USA.
EM minhal@hms.harvard.edu; ivocerda@hms.harvard.edu
OI Ahmed, Minhal/0000-0001-5347-8524; Cerda, Ivo/0000-0003-4992-9841
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NR 129
TC 15
Z9 15
U1 5
U2 13
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-0640
J9 FRONT PSYCHIATRY
JI Front. Psychiatry
PD MAR 8
PY 2023
VL 14
AR 1134865
DI 10.3389/fpsyt.2023.1134865
PG 11
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA A3VT4
UT WOS:000954448100001
PM 36970267
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Rameshkumar, R
   Larkey, L
   Alperin, K
   Martin, D
   Primus, A
   James, D
AF Rameshkumar, Ramya
   Larkey, Linda
   Alperin, Kate
   Martin, Danielle
   Primus, Antonia
   James, Dara
TI Study design exploring Qigong and Tai Chi Easy (QTC) on cardiometabolic
   risk factors
SO CONTEMPORARY CLINICAL TRIALS
LA English
DT Article
DE Qigong; Taiji; Heart rate variability; HRV biofeedback; Older adults;
   Cardiometabolic risk factors
ID RANDOMIZED CONTROLLED-TRIAL; BREAST-CANCER SURVIVORS;
   HEART-RATE-VARIABILITY; PHYSICAL-ACTIVITY; CARDIOVASCULAR-DISEASE;
   MEDITATIVE MOVEMENT; PERCEIVED STRESS; EXERCISE; OBESITY; WEIGHT
AB Background: Cardiovascular disease is the leading cause of death in the United States paralleled with several cardiometabolic risk factors that are on the rise such as obesity, hypertension, and diabetes. Many of these cardiometabolic risk factors are preventable by lifestyle changes in physical activity and dietary patterns. Qigong and Tai Chi Easy (QTC) exercises are considered meditative movement practices that have been shown to reduce cardiometabolic risk factors such as psychosocial stress, poor sleep quality and weight gain and is particularly suitable for older adults. Heart rate variability (HRV) is a common factor known to be related to reduction of these risks and may be enhanced using HRV biofeedback to specifically optimize effects of QTC.
   Methods: The protocol presented describes a two-group parallel randomized controlled trial testing effects of QTC vs QTC plus HRV biofeedback "priming" on HRV parameters (primary), and cardiometabolic risk factors and sequelae (secondary) (e.g., waist circumference/percent body fat, sleep quality, stress, anxiety/depression, emotional regulation, eating behaviors, and cognitive performance). We will enroll 50 adults aged 55-85 years old to participate in an 8-week intervention. Self-reported body measurements, psychosocial and behavioral questionnaires, and cognitive performance assessments will be conducted before and after the intervention.
   Conclusions: Findings from this study are expected to assess effects of QTC and elucidate the potential role of HRV in QTC relative to cardiometabolic risk factors and sequelae. Implications for how HRV may play a central role and be optimized in a meditative movement practice are discussed.
C1 [Rameshkumar, Ramya; Larkey, Linda; Alperin, Kate; Martin, Danielle; Primus, Antonia; James, Dara] Arizona State Univ, Edson Coll Nursing & Hlth Innovat, 500 N 3rd St, Phoenix, AZ 85004 USA.
   [Larkey, Linda; James, Dara] Arizona State Univ, Edson Coll Nursing & Hlth Innovat, Ctr Hlth Promot & Dis Prevent, 500 N 3rd St, Phoenix, AZ 85004 USA.
C3 Arizona State University; Arizona State University-Downtown Phoenix;
   Arizona State University; Arizona State University-Downtown Phoenix
RP James, D (corresponding author), Arizona State Univ, Edson Coll Nursing & Hlth Innovat, 500 N 3rd St, Phoenix, AZ 85004 USA.
EM Dara.James@asu.edu
RI Martin, Danielle/GWQ-9731-2022; James, Dara/GQA-9260-2022
OI Alperin, Kate/0009-0003-2292-5813; Martin, Danielle/0000-0001-6931-1550
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NR 59
TC 3
Z9 3
U1 3
U2 24
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1551-7144
EI 1559-2030
J9 CONTEMP CLIN TRIALS
JI Contemp. Clin. Trials
PD JUL
PY 2022
VL 118
AR 106793
DI 10.1016/j.cct.2022.106793
EA JUN 2022
PG 7
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA 3N6WM
UT WOS:000836286800014
PM 35589024
DA 2025-06-11
ER

PT J
AU Usher, K
   Foster, K
   Park, T
AF Usher, K.
   Foster, K.
   Park, T.
TI The metabolic syndrome and schizophrenia: the latest evidence and
   nursing guidelines for management
SO JOURNAL OF PSYCHIATRIC AND MENTAL HEALTH NURSING
LA English
DT Article
DE diabetes; metabolic syndrome; obesity; second-generation antipsychotic
   drugs; syndrome X
ID GLUCOSE-TOLERANCE; WEIGHT-GAIN
AB The introduction of second-generation antipsychotic drugs for the treatment of schizophrenia has provided significant benefits for clients experiencing this disorder. While they have been found effective in reducing psychotic symptoms, there is evidence that these drugs are also linked with a group of side effects commonly known as the metabolic syndrome. Mental health nurses are well positioned to prevent, detect and/or manage the development of this problematic constellation of symptoms. Guidelines for practice can be useful in prevention and management of the syndrome and enhance nursing care of clients who are taking second-generation antipsychotics.
C1 James Cook Univ, Sch Nursing Sci, Townsville, Qld 4811, Australia.
   James Cook Univ, Sch Nursing Sci, Cairns, Australia.
C3 James Cook University; James Cook University
RP Usher, K (corresponding author), James Cook Univ, Sch Nursing Sci, Townsville, Qld 4811, Australia.
EM kim.usher@jcu.edu.au
RI Park, Tanya/IYT-1163-2023; Usher, Kim/ABB-2803-2020; Park,
   Tanya/N-3285-2013
OI Usher AM, Kim/0000-0002-9686-5003; Foster, Kim/0000-0001-6931-2422;
   Park, Tanya/0000-0003-2462-7628
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NR 26
TC 40
Z9 46
U1 1
U2 13
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1351-0126
EI 1365-2850
J9 J PSYCHIATR MENT HLT
JI J. Psychiatr. Ment. Health Nurs.
PD DEC
PY 2006
VL 13
IS 6
BP 730
EP 734
DI 10.1111/j.1365-2850.2006.01026.x
PG 5
WC Nursing; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Psychiatry
GA 101XB
UT WOS:000241773500014
PM 17087676
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Howard, S
   Hu, LY
AF Howard, Simon
   Hu, Lisa Y.
TI Secondhand racism: What we know and where to go regarding the
   relationship between vicarious racism and mental and physical health
SO SOCIAL AND PERSONALITY PSYCHOLOGY COMPASS
LA English
DT Review
DE indirect racism; mental health; physical health; vicarious
   discrimination; vicarious racism
ID AFRICAN-AMERICAN WOMEN; DEPRESSIVE SYMPTOMS; HISTORICAL-TRAUMA;
   DISCRIMINATION; STRESS; EXPERIENCES; OUTCOMES; BLACK; RACE; DISPARITIES
AB Racism has long been established to be a significant determinant of racial inequalities in health among racially minoritized individuals. Most of this research, however, has been focused on individuals' direct perceived experiences of racism, and far less has been conducted on the relationship between indirect, vicarious experiences of racism and mental and physical health outcomes and behaviors. In this review, racism and vicarious racism are defined, and what is known about the relationship between vicarious experiences of racism and psychological and physical well-being and health behaviors is documented. Like direct experiences of racism, research on vicarious experiences of racism suggests it is also adversely related to anxiety, depression, general psychological distress, and physiological health (e.g., allostatic load, cardiometabolic risk). Lastly, future directions for research and clinical practice are discussed. Understanding the intricate interplay between vicarious racism and overall mental and physical wellbeing is crucial for informing interventions aimed at mitigating the adverse mental health outcomes associated with experiences with racism.
C1 [Howard, Simon; Hu, Lisa Y.] Univ Miami, Dept Psychol, 5665 Ponce Leon Blvd, Coral Gables, FL 33146 USA.
C3 University of Miami
RP Howard, S (corresponding author), Univ Miami, Dept Psychol, 5665 Ponce Leon Blvd, Coral Gables, FL 33146 USA.
EM simon.howard@miami.edu
OI Hu, Lisa/0009-0001-5253-7374
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NR 86
TC 0
Z9 0
U1 2
U2 2
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
EI 1751-9004
J9 SOC PERSONAL PSYCHOL
JI Soc. Personal. Psychol. Compass
PD NOV
PY 2024
VL 18
IS 11
AR e70012
DI 10.1111/spc3.70012
PG 16
WC Psychology, Social
WE Social Science Citation Index (SSCI)
SC Psychology
GA O1H7C
UT WOS:001368727600001
DA 2025-06-11
ER

PT J
AU Koborová, I
   Gurecká, R
   Csongová, M
   Sebek, J
   Sebeková, K
AF Koborova, I.
   Gurecka, R.
   Csongova, M.
   Sebek, J.
   Sebekova, K.
TI Plasma markers of oxidative status were associated with increasing
   continuous cardiometabolic risk scores in healthy students aged 16-20
   years without central obesity
SO ACTA PAEDIATRICA
LA English
DT Article
DE Advanced glycation; Cardiometabolic risk score; Normal weight subjects;
   Oxidative status; Protein oxidation
ID GLYCATION END-PRODUCTS; PROTEIN PRODUCTS; METABOLIC SYNDROME; ACCURATE
   METHOD; CHILDREN; STRESS; SERUM; ADOLESCENTS; DISEASE; IMPACT
AB Aim We studied the association between increased cardiometabolic risk and markers of oxidative status and glycation in apparently healthy subjects who did not present with central obesity. Methods Results From 2011 to 2012, we recruited 2064 students (53% girls) aged 16-20 years from Western Slovakia. Their continuous metabolic syndrome scores (MSS) were calculated as a mean of the sum of the z-scores of waist-to-height ratio, mean arterial pressure, triacylglycerols, high-density lipoprotein-cholesterol and quantitative insulin sensitivity check index. Plasma markers of protein glycation and oxidation, lipid peroxidation and total antioxidant status were analysed. In both genders, advanced oxidation protein products (AOPPs) increased across the MSS quintiles (p < 0.001). AOPPs and fructosamines were significant predictors of the MSS in both genders. Moreover, high-sensitivity C-reactive protein, leukocyte counts and advanced glycation end-products (AGEs) contributed significantly in girls. Triacylglycerols, fructosamines, AGEs and total antioxidant capacity correlated significantly with AOPPs in both genders. Conclusion Advanced oxidation protein products may act as inflammatory mediators that contribute to the development of cardiometabolic afflictions. Determining these may provide information related to cardiometabolic risk and represent potential target to reduce or prevent irreversible oxidative stress-induced cellular damage.
C1 [Koborova, I.; Gurecka, R.; Csongova, M.; Sebekova, K.] Comenius Univ, Fac Med, Inst Mol BioMed, Sasinkova 4, Bratislava 81108, Slovakia.
   [Koborova, I.] Comenius Univ, Fac Med, Inst Med Phys Biophys Informat & Telemed, Bratislava, Slovakia.
   [Sebek, J.] Slovak Acad Sci, Inst Mat & Machine Mech, Bratislava, Slovakia.
C3 Comenius University Bratislava; Comenius University Bratislava; Slovak
   Academy of Sciences; Institute of Materials & Machine Mechanics, SAS
RP Sebeková, K (corresponding author), Comenius Univ, Fac Med, Inst Mol BioMed, Sasinkova 4, Bratislava 81108, Slovakia.
EM kata.sebekova@gmail.com
RI Csongová, Melinda/AAJ-8811-2020; Gurecka, Radana/AAX-6744-2021;
   Sebekova, Katarina/H-4906-2016
OI Sebekova, Katarina/0000-0002-9641-9265
FU Scientific Grant Agency of the Ministry of Education, Science, Research
   and Sport of the Slovak Republic [1/0637/13]; Slovak Academy of Sciences
   [1/0637/13]; Slovak Research and Development Agency [0447-12];
   Bratislava Self-governing Region
FX This study was funded by The Scientific Grant Agency of the Ministry of
   Education, Science, Research and Sport of the Slovak Republic and the
   Slovak Academy of Sciences (grant number 1/0637/13), The Slovak Research
   and Development Agency (grant number 0447-12) and the Bratislava
   Self-governing Region. The funders had no involvement in any aspect of
   the study or paper.
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NR 30
TC 2
Z9 2
U1 0
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0803-5253
EI 1651-2227
J9 ACTA PAEDIATR
JI Acta Paediatr.
PD DEC
PY 2018
VL 107
IS 12
BP 2137
EP 2145
DI 10.1111/apa.14372
PG 9
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics
GA GZ7DU
UT WOS:000449638100020
PM 29706023
DA 2025-06-11
ER

PT J
AU Abukmail, E
   Pradeep, NK
   Ahmed, S
   Albarqouni, L
AF Abukmail, Eman
   Pradeep, Neeraj Koloth
   Ahmed, Samantha
   Albarqouni, Loai
TI Moderate- to Long-Term Effect of Dietary Interventions for Depression
   and Anxiety: A Systematic Review and Meta-analysis
SO ANNALS OF INTERNAL MEDICINE
LA English
DT Review; Early Access
ID QUALITY-OF-LIFE; ADULTS; MOOD; RESTRICTION; PATTERNS; EXERCISE; THERAPY;
   TRIAL; RISK; MEN
AB Background: Dietary interventions are a potential alternative treatment of depression and anxiety. Purpose: To evaluate the effects of dietary interventions on depression and anxiety. Data Sources: PubMed, Cochrane CENTRAL, EMBASE, CINAHL, and PsycINFO searched from inception until 12 December 2024. Trial registries and forward and backward citation analysis done on 3 January 2025. Study Selection: Randomized controlled trials (RCTs) evaluated the effect of dietary advice with or without food provision compared with no specific dietary advice or active interventions for 3 months or longer on depression and/or anxiety. Data Extraction: Two authors independently screened articles, extracted data, and assessed risk of bias. Primary outcomes included depression and anxiety symptoms at 3 months or longer. Random-effects meta-analyses were done, and the certainty of evidence was assessed. Data Synthesis: Twenty-five RCTs were included. Compared with no specific dietary advice, depressive symptoms might be improved in adults with elevated cardiometabolic risk by dietary advice on calorie restriction (standardized mean difference [SMD], -0.23 [95% CI, -0.38 to -0.09]; low certainty). Low-fat diets may also have very small effects on depressive symptoms in adults with elevated cardiometabolic risk (SMD, -0.03 [CI, -0.04 to -0.01]; low certainty). Evidence on other diets, comparing diets with active comparisons, and on anxiety was limited by study limitations and clinical or methodological heterogeneity. Limitation: Limited studies did not allow for adequate exploration of heterogeneity. Conclusion: Calorie restrictions and low-fat diets might reduce depressive symptoms among adults with elevated cardiometabolic risk, but the differences were small and confidence in the findings was low. Evidence on other diets, comparisons to active interventions, and other outcomes is limited.
C1 [Abukmail, Eman; Ahmed, Samantha; Albarqouni, Loai] Bond Univ, Inst Evidence Based Healthcare, Gold Coast, Qld, Australia.
   [Abukmail, Eman; Pradeep, Neeraj Koloth; Ahmed, Samantha; Albarqouni, Loai] Bond Univ, Fac Hlth Sci & Med, Gold Coast, Qld, Australia.
C3 Bond University; Bond University
RP Albarqouni, L (corresponding author), Bond Univ, Inst Evidence Based Healthcare, Gold Coast, Qld, Australia.
EM lalbarqo@bond.edu.au
RI Albarqouni, Loai/I-1295-2019
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NR 59
TC 0
Z9 0
U1 1
U2 1
PU AMER COLL PHYSICIANS
PI PHILADELPHIA
PA INDEPENDENCE MALL WEST 6TH AND RACE ST, PHILADELPHIA, PA 19106-1572,
   UNITED STATES
SN 0003-4819
EI 1539-3704
J9 ANN INTERN MED
JI Ann. Intern. Med.
PD 2025 MAY 20
PY 2025
DI 10.7326/ANNALS-24-03016
EA MAY 2025
PG 23
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 2WP9Y
UT WOS:001493070500001
PM 40388814
DA 2025-06-11
ER

PT J
AU Ostadmohammadi, V
   Soleimani, A
   Bahmani, F
   Aghadavod, E
   Ramezani, R
   Reiter, RJ
   Mansournia, MA
   Banikazemi, Z
   Soleimani, M
   Zaroudi, M
   Asemi, Z
AF Ostadmohammadi, Vahidreza
   Soleimani, Alireza
   Bahmani, Fereshteh
   Aghadavod, Esmat
   Ramezani, Reza
   Reiter, Russel J.
   Mansournia, Mohammad Ali
   Banikazemi, Zarrin
   Soleimani, Maryam
   Zaroudi, Marsa
   Asemi, Zatollah
TI The Effects of Melatonin Supplementation on Parameters of Mental Health,
   Glycemic Control, Markers of Cardiometabolic Risk, and Oxidative Stress
   in Diabetic Hemodialysis Patients: A Randomized, Double-Blind,
   Placebo-Controlled Trial
SO JOURNAL OF RENAL NUTRITION
LA English
DT Article
ID CHRONIC KIDNEY-DISEASE; QUALITY-OF-LIFE; INSULIN-RESISTANCE;
   GLUCOSE-TOLERANCE; SLEEP QUALITY; INFLAMMATION; SCHIZOPHRENIA;
   INVENTORY; SECRETION; IMPROVES
AB Objective: This study evaluated the effects of melatonin supplementation on parameters of mental health, glycemic control, markers of cardiometabolic risk, and oxidative stress in diabetic hemodialysis (HD) patients.
   Design: A randomized, double-blind, placebo-controlled clinical trial was conducted in 60 diabetic HD patients, 18-80 years of age. Participants were randomly divided into 2 groups to take either melatonin (2 x 5mg/day) (n = 30) or placebo (n = 30) 1 hour before bedtime for 12 weeks. The effects of melatonin on mental health, metabolic status, and gene expression related to metabolic status were assessed using multiple linear regression adjusting for age and BMI.
   Results: Melatonin supplementation significantly decreased Pittsburgh Sleep Quality Index (P = .007), Beck Depression Inventory index (P = .001), and Beck Anxiety Inventory index (P = .01) compared with the placebo. Additionally, melatonin administration significantly reduced fasting plasma glucose (beta = -21.77 mg/dL, 95% CI -33.22 to -10.33, P < .001), serum insulin levels (beta = -1.89 IU/mL, 95% CI -3.34 to -0.45, P = .01), and homeostasis model of assessment-insulin resistance (beta = -1.45, 95% CI -2.10 to -0.80, P < .001), and significantly increased the quantitative insulin sensitivity check index (beta = 0.01, 95% CI 0.007-0.02, P < .001) compared with placebo treated subjects. In addition, melatonin administration resulted in a significant reduction in serum high sensitivity C-reactive protein (beta = -1.92 mg/L, 95% CI -3.02 to -0.83, P = .001) and plasma malondialdehyde (beta = -0.21 mu mol/L, 95% CI -0.36 to -0.06, P = .005); also, significant rises in plasma total antioxidant capacity (beta = 253.87 mmol/L, 95% CI 189.18-318.56, P < .001) and nitric oxide levels (beta = 2.99 mu mol/L, 95% CI 0.71-5.28, P = .01) were observed compared with the placebo.
   Conclusion: Overall, melatonin supplementation for 12 weeks to diabetic HD patients had beneficial effects on mental health, glycemic control, inflammatory markers, and oxidative stress. (C) 2019 by the National Kidney Foundation, Inc. All rights reserved.
C1 [Ostadmohammadi, Vahidreza; Bahmani, Fereshteh; Aghadavod, Esmat; Ramezani, Reza; Banikazemi, Zarrin; Soleimani, Maryam; Asemi, Zatollah] Kashan Univ Med Sci, Res Ctr Biochem & Nutr Metab Dis, Kashan, Iran.
   [Soleimani, Alireza] Kashan Univ Med Sci, Dept Internal Med, Kashan, Iran.
   [Reiter, Russel J.] UT Hlth San Antonio, Dept Cellular & Struct Biol, San Antonio, TX USA.
   [Mansournia, Mohammad Ali] Univ Tehran Med Sci, Sch Publ Hlth, Dept Epidemiol & Biostat, Tehran, Iran.
   [Zaroudi, Marsa] Iran Univ Med Sci, Fac Publ Hlth Branch, Student Res Comm, Tehran, Iran.
C3 University of Texas System; University of Texas Health Science Center at
   San Antonio; Tehran University of Medical Sciences; Iran University of
   Medical Sciences
RP Asemi, Z (corresponding author), Kashan Univ Med Sci, Res Ctr Biochem & Nutr Metab Dis, Kashan, Iran.
EM asemi_r@yahoo.com
RI Reiter, Russel/D-3221-2009; mansournia, Mohammad/AFA-8899-2022; Bahmani,
   Fereshteh/G-7641-2017; asemi, zatollah/J-2677-2018; Ostadmohammadi,
   Vahidreza/A-6248-2018; Aghadavod, Esmat/I-7736-2017
OI Ostadmohammadi, Vahidreza/0000-0002-4633-5397; Aghadavod,
   Esmat/0000-0001-9456-9238
FU KAUMS, Iran [96204]
FX The present study was supported by a grant from the Vice-chancellor for
   Research, KAUMS, Iran (grant no. 96204). The authorswould like to thank
   the staff of Akhavan Clinic (Kashan, Iran) for their assistance in this
   project.
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NR 55
TC 46
Z9 46
U1 0
U2 11
PU W B SAUNDERS CO-ELSEVIER INC
PI PHILADELPHIA
PA 1600 JOHN F KENNEDY BOULEVARD, STE 1800, PHILADELPHIA, PA 19103-2899 USA
SN 1051-2276
EI 1532-8503
J9 J RENAL NUTR
JI J. Renal Nutr.
PD MAY
PY 2020
VL 30
IS 3
BP 242
EP 250
DI 10.1053/j.jrn.2019.08.003
PG 9
WC Nutrition & Dietetics; Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nutrition & Dietetics; Urology & Nephrology
GA LP3NA
UT WOS:000534224500010
PM 31597622
DA 2025-06-11
ER

PT J
AU Guest, AJ
   Chen, YL
   Pearson, N
   King, JA
   Paine, NJ
   Clemes, SA
AF Guest, Amber J.
   Chen, Yu-Ling
   Pearson, Natalie
   King, James A.
   Paine, Nicola J.
   Clemes, Stacy A.
TI Cardiometabolic risk factors and mental health status among truck
   drivers: a systematic review
SO BMJ OPEN
LA English
DT Review
DE epidemiology; occupational &amp; industrial medicine; preventive
   medicine; public health
ID LONG-HAUL TRUCK; BODY-MASS INDEX; PHYSICAL-ACTIVITY; METABOLIC SYNDROME;
   WORK ORGANIZATION; BLOOD-PRESSURE; CARDIOVASCULAR-DISEASE; VEGETABLE
   CONSUMPTION; PROFESSIONAL DRIVERS; AUSTRALIAN TRUCK
AB Objective This study aimed to systematically review and summarise the literature on cardiometabolic risk factors, lifestyle health behaviours and mental health status of truck drivers globally to ascertain the scale of these health concerns. Design Systematic review reported using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Data sources PubMed, Scopus, PsycINFO and Web of Science were searched in January 2019 and updated in January 2020, from the date of inception to 16 January 2020. Eligibility criteria for selecting studies Papers were included if they (1) reported independent data on truck drivers, (2) included quantitative data on outcomes related to cardiometabolic markers of health, mental health and/or health behaviours, (3) were written in English and (4) were published in a peer-reviewed journal. Grey literature was ineligible for this review. Data extraction and synthesis One reviewer independently extracted data and assessed methodological quality using a checklist based on the National Heart, Lung and Blood Institute Quality Assessment tool. 20% were independently assessed for eligibility and quality by a second reviewer. Due to heterogeneity of the outcomes, results were narratively presented. Results 3601 titles and abstracts were screened. Seventy-three studies met the inclusion criteria. Truck driving is associated with enforced sedentarism, long and irregular working hours, lack of healthy foods, social isolation and chronic time pressures. Strong evidence was observed for truck drivers to generally exhibit poor cardiometabolic risk profiles including overweight and obesity, hypertension, hypercholesterolaemia, high blood glucose, poor mental health and cigarette smoking. Conclusions Improving truck driver health is vital for the longevity of the trucking industry, and for the safety of all road users. The workplace plays a vital role in truck driver health; policies, regulations and procedures are required to address this health crisis. PROSPERO registration number CRD42019124499.
C1 [Guest, Amber J.; Chen, Yu-Ling; Pearson, Natalie; King, James A.; Paine, Nicola J.; Clemes, Stacy A.] Loughborough Univ, Sch Sport Exercise & Hlth Sci, Loughborough, Leics, England.
   [King, James A.; Clemes, Stacy A.] Univ Hosp Leicester NHS Trust, NIHR Leicester Biomed Res Ctr, Leicester, Leics, England.
   [King, James A.; Clemes, Stacy A.] Univ Leicester, Leicester, Leics, England.
C3 Loughborough University; University Hospitals of Leicester NHS Trust;
   University of Leicester; University of Leicester
RP Guest, AJ (corresponding author), Loughborough Univ, Sch Sport Exercise & Hlth Sci, Loughborough, Leics, England.
EM a.guest@lboro.ac.uk
OI pearson, natalie/0000-0003-2060-5966; Paine, Nicola/0000-0001-9988-9310;
   Guest, Amber J/0000-0002-3610-347X; Clemes, Stacy/0000-0001-5612-5898;
   King, James/0000-0002-8174-9173
FU Colt Foundation; NIHR Public Health Research Programme (NIHR PHR)
   [15/190/42]; NIHR Leicester Biomedical Research Centre-Lifestyle theme
FX The first author (AG) has received funding for their PhD Studentship
   from the Colt Foundation. The Colt Foundation had no role in study
   design; election, synthesis and interpretation of data; writing of the
   report; or the decision to submit the manuscript for publication. SC and
   JAK are in receipt of funding from the NIHR Public Health Research
   Programme (reference: NIHR PHR 15/190/42) for the evaluation of a
   multi-component health behaviour intervention in truck drivers. They are
   also supported by the NIHR Leicester Biomedical Research
   Centre-Lifestyle theme. The views expressed are those of the authors and
   not necessarily those of the NHS, the NIHR or the Department of Health
   and Social Care.
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NR 126
TC 36
Z9 37
U1 2
U2 18
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2044-6055
J9 BMJ OPEN
JI BMJ Open
PY 2020
VL 10
IS 10
AR e038993
DI 10.1136/bmjopen-2020-038993
PG 12
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA OP4MV
UT WOS:000588056700011
PM 33099498
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Dagogo-Jack, S
   Egbuonu, N
   Edeoga, C
AF Dagogo-Jack, Samuel
   Egbuonu, Nonso
   Edeoga, Chimaroke
TI Principles and Practice of Nonpharmacological Interventions to Reduce
   Cardiometabolic Risk
SO MEDICAL PRINCIPLES AND PRACTICE
LA English
DT Review
DE Prediabetes; Diet; Exercise; Smoking cessation; Community prevention
ID IMPAIRED GLUCOSE-TOLERANCE; CARDIOVASCULAR-DISEASE; INSULIN-RESISTANCE;
   PRIMARY PREVENTION; METABOLIC SYNDROME; WEIGHT-LOSS; TYPE-2;
   ASSOCIATION; COMPLICATIONS; POLYMORPHISMS
AB The components of the metabolic syndrome, including prediabetes, prehypertension and dyslipidemia, represent prodromal stages of major cardiometabolic disorders. Lifestyle interventions have been shown to ameliorate or prevent the progression of individual components of the metabolic syndrome. The specific interventions utilized in randomized controlled studies often include dietary modification and physical activity. The effects of smoking cessation and the reduction of psychosocial stress on cardiometabolic risk factors need to be studied more. Because of the close concordance between the metabolic syndrome and multiple cardiometabolic diseases, the adoption of an effective lifestyle change upon initial recognition of the metabolic syndrome can be expected to delay or prevent the future development of sequelae such as diabetes, hypertension, and atherosclerotic cardiovascular and cerebrovascular diseases. Such a nonpharmacological approach to primary prevention and disease interruption carries enormous public health significance. Meeting the challenge of an implementation of effective lifestyle change at the community level requires (a) a system for the identification of at-risk populations, (b) an optimization of the knowledge base and practices of health care providers, and ( c) a piloting of targeted biobehavioral intervention programs. Once identified, persons and communities at risk for cardiometabolic disorders can be empowered through increased health and nutritional literacy, the promotion of lifestyle interventions, provision of community resources, and pertinent legislative action that rewards preventive behavior. This paper reviews landmark studies that demonstrate the principles of nonpharmacological approaches to the reduction of cardiometabolic risk. We also discuss the physiological and emerging molecular genetic mechanisms that underlie the efficacy of lifestyle interventions. Copyright (C) 2010 S. Karger AG, Basel
C1 [Dagogo-Jack, Samuel; Egbuonu, Nonso; Edeoga, Chimaroke] Univ Tennessee, Hlth Sci Ctr, Div Endocrinol Diabet & Metab, Memphis, TN 38163 USA.
C3 University of Tennessee System; University of Tennessee Health Science
   Center
RP Dagogo-Jack, S (corresponding author), Univ Tennessee, Hlth Sci Ctr, Div Endocrinol Diabet & Metab, 920 Madison Ave,Suite 300A, Memphis, TN 38163 USA.
EM sdj@utmem.edu
FU National Institutes of Health [R01 DK067269, M01 RR00211]; American
   Diabetes Association
FX The authors acknowledge support from the National Institutes of Health (
   grants R01 DK067269 and M01 RR00211) and the American Diabetes
   Association.
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NR 42
TC 49
Z9 55
U1 0
U2 13
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1011-7571
EI 1423-0151
J9 MED PRIN PRACT
JI Med. Princ. Pract.
PY 2010
VL 19
IS 3
BP 167
EP 175
DI 10.1159/000285280
PG 9
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 577TB
UT WOS:000276245800001
PM 20357497
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Benson, S
   Arck, PC
   Tan, S
   Hahn, S
   Mann, K
   Rifaie, N
   Janssen, OE
   Schedlowski, M
   Elsenbruch, S
AF Benson, S.
   Arck, P. C.
   Tan, S.
   Hahn, S.
   Mann, K.
   Rifaie, N.
   Janssen, O. E.
   Schedlowski, M.
   Elsenbruch, S.
TI Disturbed stress responses in women with polycystic ovary syndrome
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE Polycystic ovary syndrome; Psychological stress; Cardiovascular system;
   Immune system; Obesity
ID LOW-GRADE INFLAMMATION; METABOLIC SYNDROME; INSULIN-RESISTANCE;
   YOUNG-WOMEN; NEUROENDOCRINE RESPONSES; PSYCHOSOCIAL STRESS; MAJOR
   DEPRESSION; BLOOD-PRESSURE; FOLLOW-UP; CORTISOL
AB Background: We analyzed the neuroendocrine and immune cell responses to psychosocial stress in PCOS patients compared to BMI-matched healthy controls.
   Methods: Responses to public speaking stress were analyzed in 32 PCOS patients and 32 BMI-matched healthy controls. At baseline, during, and 10- and 45-min after stress, state anxiety, cardiovascular responses, cortisol, ACTH, as welt as circulating leukocyte subpopulations were analyzed, together with hsCRP and serum IL-6 concentrations.
   Results: In response to public speaking stress, both groups showed significant but comparable increases in state anxiety, and blood pressure (all p < 0.001; time effects). The ACTH and cortisol stress responses were significantly enhanced in PCOS (both p < 0.05; interaction effect). In addition, heart rate was significantly higher in PCOS (p < 0.05; group effect). PCOS patients displayed a reduced upregulation of IL-6 levels in response to stress (p < 0.05; interaction effect). Baseline levels of circulating leukocyte subpoputations, IL-6 and hsCRP concentrations did not differ between BMI-matched controls and PCOS patients. PCOS patients were characterized by markedly increased psychological distress.
   Conclusions: PCOS patients showed enhanced HPA-axis and heart rate reactivity as well as a reduced upregulation of IL-6 in response to stress. The altered stress reactivity in PCOS patients may constitute a link between depression, overweight, and the cardiovascular and diabetes risks associated with the diagnosis. (C) 2008 Elsevier Ltd. All rights reserved.
C1 [Benson, S.; Schedlowski, M.; Elsenbruch, S.] Univ Duisburg Essen, Dept Med Psychol & Behav Immunobiol, Univ Hosp Essen, D-45122 Essen, Germany.
   [Arck, P. C.] Charite Univ Med Berlin, Ctr Internal Med & Dermatol, Clin Internal Med & Psychosomat, D-13353 Berlin, Germany.
   [Tan, S.] Univ Duisburg Essen, Dep Endocrinol, Univ Hosp Essen, D-45122 Essen, Germany.
   [Tan, S.] Univ Duisburg Essen, Div Lab Res, Univ Hosp Essen, D-45122 Essen, Germany.
   [Hahn, S.] Ctr Endocrine & Metab Dis, Wuppertal, Germany.
   [Mann, K.; Janssen, O. E.] Ctr Endocrine & Metab Dis, Hamburg, Germany.
C3 University of Duisburg Essen; Berlin Institute of Health; Free
   University of Berlin; Humboldt University of Berlin; Charite
   Universitatsmedizin Berlin; University of Duisburg Essen; University of
   Duisburg Essen
RP Elsenbruch, S (corresponding author), Univ Duisburg Essen, Dept Med Psychol & Behav Immunobiol, Univ Hosp Essen, Hufelandstr 55, D-45122 Essen, Germany.
EM sigrid.elsenbruch@uk-essen.de
RI Schedlowski, Manfred/GLU-7519-2022; Tan, Susanne/GLN-3251-2022; Arck,
   Petra/D-7094-2013; Benson, Sven/I-1981-2014
OI Arck, Petra Clara/0000-0002-2932-926X; Reger-Tan,
   Susanne/0000-0003-2692-8643; Benson, Sven/0000-0002-4487-4258;
   Elsenbruch, Sigrid/0000-0002-6528-2665
FU Lienert-Stiftung
FX The authors would like to express their gratitude to Katia Brassmann,
   Petra Busse, Evetin Hagen, Andrea Jaeger, and Natalie Riemenschneider
   for excellent technical support.Sven Benson was supported by a stipend
   from the Lienert-Stiftung.
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NR 53
TC 92
Z9 101
U1 1
U2 18
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD JUN
PY 2009
VL 34
IS 5
BP 727
EP 735
DI 10.1016/j.psyneuen.2008.12.001
PG 9
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA 444BC
UT WOS:000265953900010
PM 19150179
DA 2025-06-11
ER

PT J
AU Reverri, EJ
   LaSalle, CD
   Franke, AA
   Steinberg, FM
AF Reverri, Elizabeth J.
   LaSalle, Colette D.
   Franke, Adrian A.
   Steinberg, Francene M.
TI Soy provides modest benefits on endothelial function without affecting
   inflammatory biomarkers in adults at cardiometabolic risk
SO MOLECULAR NUTRITION & FOOD RESEARCH
LA English
DT Article
DE Cardiometabolic risk; Endothelial function; Inflammation; Isoflavone;
   Soy
ID CORONARY-HEART-DISEASE; POSTMENOPAUSAL WOMEN; METABOLIC SYNDROME;
   BLOOD-PRESSURE; ISOFLAVONE SUPPLEMENTATION; CARDIOVASCULAR-DISEASE;
   INSULIN SENSITIVITY; ADHESION MOLECULES; PROTEIN; EQUOL
AB Scope: Systemic inflammation, endothelial dysfunction, and oxidative stress are involved in the pathogenesis of the metabolic syndrome (MetS). Epidemiological evidence supports an association between whole soy food consumption and reduced risk of cardiovascular disease (CVD). The objective of this randomized, controlled, cross-over study was to evaluate the effects of soy nut consumption on inflammatory biomarkers and endothelial function and to assess whether isoflavone metabolism to secondary products, equol, and/or O-desmethylangolensin (ODMA), modifies these responses.
   Methods and results: n = 17 adults at cardiometabolic risk were randomly assigned to the order of two snack interventions, soy nuts, and macronutrient-matched control snack, for four weeks each, separated by a two week washout period. Outcome measures included biomarkers of inflammation, oxidative stress, and glycemic control (ELISA and clinical analyzers), endothelial function, and arterial stiffness (peripheral arterial tonometry (PAT)), and isoflavone metabolites (LC-MS/MS). Results revealed that consuming soy nuts improved arterial stiffness as assessed by the augmentation index using PAT (p = 0.03), despite lack of improvement in inflammatory biomarkers. Addition of equol and/or ODMA production status as covariates did not significantly change these results.
   Conclusion: Soy nuts when added to a usual diet for one month provide some benefit on arterial stiffness in adults at cardiometabolic risk.
C1 [Reverri, Elizabeth J.; LaSalle, Colette D.; Steinberg, Francene M.] Univ Calif Davis, Dept Nutr, Davis, CA 95616 USA.
   [Franke, Adrian A.] Univ Hawaii, Dept Food Sci & Human Nutr, Honolulu, HI 96822 USA.
C3 University of California System; University of California Davis;
   University of Hawaii System
RP Steinberg, FM (corresponding author), Univ Calif Davis, Dept Nutr, One Shields Ave,3135B Meyer Hall, Davis, CA 95616 USA.
EM fmsteinberg@ucdavis.edu
RI Reverri, Elizabeth/H-3840-2014
OI Reverri, Elizabeth/0000-0001-7692-0901
FU USDA Agricultural Research Service (CRIS) [CA-D*NTR-6316-H]; University
   of California, Davis Henry A. Jastro Research Awards [GGNBEJ1, GGNBEJ2];
   University of California, Davis Humanities Research Award [FMSEJGS]; NIH
   [P30 CA71789, S10 RR020890]
FX Study funding was provided by the USDA Agricultural Research Service
   (CRIS # CA-D*NTR-6316-H), University of California, Davis Henry A.
   Jastro Research Awards (grant numbers GGNBEJ1 and GGNBEJ2), and
   University of California, Davis Humanities Research Award (grant number
   FMSEJGS). NIH grants P30 CA71789 and S10 RR020890 supported the LC-MS/MS
   analyses. Genisoy (R) Food Company, Inc. donated the soy nuts and had no
   role in the design, analysis, or writing of this study.
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NR 71
TC 50
Z9 53
U1 0
U2 19
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1613-4125
EI 1613-4133
J9 MOL NUTR FOOD RES
JI Mol. Nutr. Food Res.
PD FEB
PY 2015
VL 59
IS 2
BP 323
EP 333
DI 10.1002/mnfr.201400270
PG 11
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA CA8HH
UT WOS:000349158100014
PM 25351805
OA Green Accepted, Green Submitted
DA 2025-06-11
ER

PT J
AU Dreber, H
   Reynisdottir, S
   Angelin, B
   Hemmingsson, E
AF Dreber, Helena
   Reynisdottir, Signy
   Angelin, Bo
   Hemmingsson, Erik
TI Who is the Treatment-Seeking Young Adult with Severe Obesity: A
   Comprehensive Characterization with Emphasis on Mental Health
SO PLOS ONE
LA English
DT Article
ID BODY-MASS INDEX; QUALITY-OF-LIFE; BARIATRIC SURGERY; PSYCHOLOGICAL
   OUTCOMES; PSYCHOSOCIAL STATUS; CONSTRUCT-VALIDITY; HOSPITAL ANXIETY;
   GASTRIC BYPASS; UNITED-STATES; SELF-ESTEEM
AB Objective
   To characterize treatment-seeking young adults (16-25 years) with severe obesity, particularly mental health problems.
   Study Design and Participants
   Cross-sectional study of 165 participants (132 women, 33 men) with BMI >= 35 kg/m(2) or >= 30 kg/m(2) with comorbidities, enrolling in a multidisciplinary obesity treatment program.
   Method
   Data collection at admission of present and life-time health issues including symptomatology of anxiety, depression (Hospital Anxiety and Depression Scale) and attention-deficit/hyperactivity disorder (Adult ADHD Self-Report scale); self-esteem (Rosenberg Self-Esteem Scale), suicide attempts, health-related quality of life (Short Form-36 Health Survey), psychosocial functioning related to obesity (Obesity-related Problems Scale), cardiorespiratory fitness (Astrand's bicycle ergometer test), somatic and psychiatric comorbidities, cardiometabolic risk factors, and micronutritional status. We used multiple regression analysis to identify variables independently associated with present anxiety and depressive symptomatology.
   Results
   Mean body mass index was 39.2 kg/m(2) (SD = 5.2). We found evidence of poor mental health, including present psychiatric diagnoses (29%), symptomatology of anxiety (47%), depression (27%) and attention-deficit/hyperactivity disorder (37%); low self-esteem (42%), attempted suicide (12%), and low quality of life (physical component score = 46, SD = 11.2; mental component score = 36, SD = 13.9, P<0.001 for difference). Variables independently associated with present anxiety symptomatology (R-2 = 0.33, P<0.001) included low selfesteem (P<0.001) and pain (P = 0.003), whereas present depressive symptomatology (R-2 = 0.38, P<0.001) was independently associated with low self-esteem (P<0.001), low cardiorespiratory fitness (P = 0.009) and obesity-related problems (P = 0.018). The prevalence of type 2 diabetes was 3%, and hypertension 2%. Insulin resistance was present in 82%, lipid abnormality in 62%, and poor cardiorespiratory fitness in 92%. Forty-eight percent had at least one micronutritional deficiency, vitamin D being the most common (35%).
   Conclusion
   A wide range of health issues, including quite severe mental health problems, was prevalent in treatment-seeking young adults with severe obesity. These are likely to constitute a major treatment challenge, including options relating to bariatric surgery.
C1 [Dreber, Helena; Reynisdottir, Signy; Hemmingsson, Erik] Karolinska Inst, Dept Med, Karolinska Univ Hosp, Obes Ctr, Stockholm, Sweden.
   [Angelin, Bo] Karolinska Inst, Dept Med, Stockholm, Sweden.
C3 Karolinska Institutet; Karolinska University Hospital; Karolinska
   Institutet
RP Dreber, H (corresponding author), Karolinska Inst, Dept Med, Karolinska Univ Hosp, Obes Ctr, Stockholm, Sweden.
EM helena.dreber@ki.se
RI Hemmingsson, Erik/MFI-5966-2025
OI Hemmingsson, Erik/0000-0001-7335-3796
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NR 73
TC 24
Z9 27
U1 0
U2 18
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD DEC 22
PY 2015
VL 10
IS 12
AR e0145273
DI 10.1371/journal.pone.0145273
PG 17
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Science & Technology - Other Topics
GA CZ4SH
UT WOS:000367092500034
PM 26694031
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Takeuchi, T
   Nakao, M
   Nomura, K
   Yano, E
AF Takeuchi, T.
   Nakao, M.
   Nomura, K.
   Yano, E.
TI Association of metabolic syndrome with depression and anxiety in
   Japanese men
SO DIABETES & METABOLISM
LA English
DT Article
DE Anxiety; Depression; Japan; Metabolic syndrome; Workers
ID JOB CONTENT QUESTIONNAIRE; MAJOR DEPRESSION; YOUNG-ADULTS; SYMPTOMS;
   VERSION; RISK; RELIABILITY; EMPLOYEES; VALIDITY; WOMEN
AB Aim. - The evidence is conflicting as to whether or not metabolic syndrome (MetS) is associated with depression and anxiety. For this reason, we have investigated the association of MetS with depression and anxiety in Japanese men.
   Methods. - MetS was defined as in the new (2006) criteria of the International Diabetes Federation (IDF), and depression and anxiety were assessed using the Profile of mood states (POMS), in 1215 male Japanese workers. The relationship between MetS and these mental conditions was assessed by logistic-regression analysis after controlling for age, gender, obesity, medical history (cardiovascular disease and diabetes), lifestyle habits (smoking, alcohol consumption, exercise and sleep) and work situation. Trend analyses for a positive association between MetS components and depression and anxiety were also performed.
   Results. - A total of 148 (12.2%), 92 (7.6%) and 170 (14.0%) patients were diagnosed with MetS, depression and anxiety, respectively. MetS was significantly related to depression, and waist circumference contributed significantly to the relationship. Trend analysis of the number of positive MetS components and depression showed a positive trend that was of borderline significance (P-trend = 0.06). No relationship was found between MetS and anxiety. Trend analysis of the number of positive MetS components and anxiety failed to show it clear trend (P-trend = 0.57).
   Conclusion. - A positive relationship was found between MetS and depression, but not between MetS and anxiety. in male Japanese workers. The specific factors comprising MetS, such as waist circumference, may be a reflection of the depression. (C) 2008 Elsevier Masson SAS. All rights reserved.
C1 [Takeuchi, T.; Nakao, M.; Nomura, K.; Yano, E.] Teikyo Univ, Sch Med, Dept Hyg & Publ Hlth, Tokyo 1738605, Japan.
   [Takeuchi, T.; Nakao, M.; Nomura, K.] Teikyo Univ Hosp, Div Psychosomat Med, Tokyo, Japan.
C3 Teikyo University; Teikyo University
RP Takeuchi, T (corresponding author), Teikyo Univ, Sch Med, Dept Hyg & Publ Hlth, 2-11-1 Kaga, Tokyo 1738605, Japan.
EM takeakij@post.harvard.edu
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NR 27
TC 59
Z9 61
U1 1
U2 12
PU MASSON EDITEUR
PI MOULINEAUX CEDEX 9
PA 21 STREET CAMILLE DESMOULINS, ISSY, 92789 MOULINEAUX CEDEX 9, FRANCE
SN 1262-3636
EI 1878-1780
J9 DIABETES METAB
JI Diabetes Metab.
PD FEB
PY 2009
VL 35
IS 1
BP 32
EP 36
DI 10.1016/j.diabet.2008.06.006
PG 5
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism
GA 419TZ
UT WOS:000264243900005
PM 19046916
DA 2025-06-11
ER

PT J
AU O'Flaherty, B
   Neigh, GN
   Rainnie, D
AF O'Flaherty, Brendan
   Neigh, Gretchen N.
   Rainnie, Donald
TI High-fructose diet initiated during adolescence does not affect
   basolateral amygdala excitability or affective-like behavior in Sprague
   Dawley rats
SO BEHAVIOURAL BRAIN RESEARCH
LA English
DT Article
DE Fructose; Amygdala; Anxiety; Depression; Sprague Dawley
ID DEPRESSIVE-LIKE BEHAVIOR; FORCED SWIM TEST; METABOLIC SYNDROME; CORN
   SYRUP; INSULIN-RESISTANCE; OPEN-FIELD; HIGH-FAT; WISTAR; PREVALENCE;
   ENRICHMENT
AB Patients with type-2 diabetes, obesity, and metabolic syndrome have a significantly increased risk of developing depression. Dysregulated metabolism may contribute to the etiology of depression by affecting neuronal activity in key limbic areas. The basolateral amygdala (BLA) acts as a critical emotional valence detector in the brain's limbic circuit, and shows hyperactivity and abnormal glucose metabolism in depressed patients. Furthermore, administering a periadolescent high-fructose diet (HFrD; a model of metabolic syndrome) to male Wistar rats increases anxiety- and depressive-like behavior. Repeated shock stress in Sprague Dawley rats similarly increases anxiety-like behavior and increases BLA excitability. We therefore investigated whether a metabolic stressor (HFrD) would have similar effects as shock stress on BLA excitability in Sprague Dawley rats. We found that a HFrD did not affect the intrinsic excitability of BLA neurons. Fructose-fed Sprague Dawley rats had elevated body fat mass, but did not show increases in metabolic efficiency and fasting blood glucose relative to control. Finally unlike Wistar rats, fructose-fed Sprague Dawley rats did not show increased anxiety- and depressive-like behavior. These results suggest that genetic differences between rat strains may affect susceptibility to a metabolic insult. Collectively, these data show that a periadolescent HFrD disrupts metabolism, but does not change affective behavior or BLA excitability in Sprague Dawley rats.
C1 [O'Flaherty, Brendan; Rainnie, Donald] Emory Univ, Sch Med, Dept Behav Neurosci & Psychiat Disorders, Yerkes Natl Primate Res Ctr,Dept Psychiat & Behav, Atlanta, GA 30329 USA.
   [Neigh, Gretchen N.] Emory Univ, Dept Physiol, Atlanta, GA 30322 USA.
   [Neigh, Gretchen N.] Virginia Commonwealth Univ, Dept Anat & Neurobiol, Med Coll Virginia Campus, Richmond, VA 23298 USA.
C3 Emory University; Emory University; Virginia Commonwealth University
RP Rainnie, D (corresponding author), 2703 Glenbriar Dr, Atlanta, GA 30345 USA.
EM tigrainnie@gmail.com
RI Neigh, Gretchen/AAW-5691-2020; Neigh, Gretchen/G-3662-2011; Rainnie,
   Donald/L-3853-2016
OI Neigh, Gretchen/0000-0003-0955-9161; O'Flaherty,
   Brendan/0000-0002-8774-6715; Rainnie, Donald/0000-0003-0758-0530
FU NIH [5F31MH111224-02, 5R01MH0698520-12]; NIH Yerkes National Primate
   Research Center Base Grant [RR-00165]
FX This research was supported by the NIH Grant 5F31MH111224-02 to BMO, NIH
   Grant 5R01MH0698520-12 to DGR, and the NIH Yerkes National Primate
   Research Center Base Grant RR-00165.
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NR 76
TC 9
Z9 9
U1 1
U2 22
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0166-4328
EI 1872-7549
J9 BEHAV BRAIN RES
JI Behav. Brain Res.
PD JUN 3
PY 2019
VL 365
BP 17
EP 25
DI 10.1016/j.bbr.2019.02.042
PG 9
WC Behavioral Sciences; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Behavioral Sciences; Neurosciences & Neurology
GA HR9EY
UT WOS:000463463200003
PM 30807811
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Redei, EE
AF Redei, Eva E.
TI Molecular genetics of the stress-responsive adrenocortical axis
SO ANNALS OF MEDICINE
LA English
DT Review
DE adrenal cortex; corticosterone; cortisol; metabolic syndrome X; obesity;
   polygenic inheritance; quantitative trait loci; stress
ID CORTICOSTEROID-BINDING GLOBULIN; PITUITARY-ADRENAL AXIS; ALDOSTERONE
   SYNTHASE GENE; QUANTITATIVE TRAIT LOCI; CORTICOTROPIN-RELEASING HORMONE;
   GROWTH-FACTOR-I; NEUROPEPTIDE-Y; LEU7PRO POLYMORPHISM; SUPRACHIASMATIC
   NUCLEUS; MAJOR DEPRESSION
AB Stress-responsive adrenocortical function is the final physiological response to the cascade of events that occurs when the interaction between individuals and their environment takes place. Glucocorticoids are produced in response to perturbance of homeostasis and are necessary for the energy required to restore this homeostasis. Genetics contributes to the individual variation in basal and stimulated plasma glucocorticoid levels and also to adrenal gland mass that increases in response to prolonged adrenal stimulation. This review briefly describes regulation of the adrenocortical axis, summarizes the linkage studies carried out so far in humans and in model organisms, and discusses the potential candidate genes that might contribute to the variation. The significance of individual variations in the glucocorticoid stress-responsiveness, with particular attention to their potential role in the recent explosion of obesity and the prevalence of metabolic syndrome X, is commented upon.
C1 [Redei, Eva E.] Northwestern Univ, Feinberg Sch Med, Asher Ctr, Dept Psychiat & Behav Sci, Chicago, IL 60611 USA.
C3 Northwestern University; Feinberg School of Medicine
RP Redei, EE (corresponding author), 303 E Chicago Ave,Ward 9-217, Chicago, IL 60611 USA.
EM e-redei@northwestern.edu
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NR 104
TC 23
Z9 26
U1 0
U2 6
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0785-3890
EI 1365-2060
J9 ANN MED
JI Ann. Med.
PY 2008
VL 40
IS 2
BP 139
EP 148
DI 10.1080/07853890701724863
PG 10
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 267JN
UT WOS:000253505400006
PM 18293144
OA Bronze
DA 2025-06-11
ER

PT J
AU Sridhar, GR
AF Sridhar, G. R.
TI Psychiatric co-morbidity & diabetes
SO INDIAN JOURNAL OF MEDICAL RESEARCH
LA English
DT Review
DE antipsychotic drugs; depression; diabetes
ID IMPAIRED GLUCOSE-TOLERANCE; EATING-DISORDERS; ATYPICAL ANTIPSYCHOTICS;
   MENTAL-DISORDERS; YOUNG-WOMEN; METABOLIC SYNDROME; INSULIN; PREVALENCE;
   HEALTH; DEPRESSION
AB Diabetes mellitus as well as psychiatric disorders are common. These may occur with one another and/or one may worsen the other. Psychological stress may follow screening for diabetes, as well as when diabetes is first identified. Acting through the hypothalamo-pituitary-adrenal axis, stress may initiate or worsen hyperglycaemia. Depression may be a risk factor for the development of diabetes; it also commonly occurs in subjects with diabetes. Identification and management are both important in preventing the disability. A variety of-antipsychotic medications, especially the newer agents can induce weight gain, dyslipidaemia, insulin resistance and diabetes. Therefore in choosing a drug, one must consider the risk factors and screen for metabolic syndrome. Subjects with type I diabetes can have cognitive dysfunction, eating disorders and developmental disturbances. Physicians caring for people with diabetes must be trained to recognize and manage co-morbid psychiatric conditions that commonly occur. A biopsychosocial disease model for both conditions can leverage the social strengths and medical knowledge in developing countries.
C1 Endocrine & Diabet Ctr, Visakhapatnam 530002, Andhra Pradesh, India.
RP Sridhar, GR (corresponding author), Endocrine & Diabet Ctr, 15-12-16 Krishnanagar, Visakhapatnam 530002, Andhra Pradesh, India.
EM grsridhar@hotmail.com
OI Sridhar, Gumpeny, R/0000-0002-7446-1251
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NR 83
TC 14
Z9 18
U1 0
U2 9
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, 400059, INDIA
SN 0971-5916
J9 INDIAN J MED RES
JI Indian J. Med. Res.
PD MAR
PY 2007
VL 125
IS 3
BP 311
EP 320
PG 10
WC Immunology; Medicine, General & Internal; Medicine, Research &
   Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; General & Internal Medicine; Research & Experimental
   Medicine
GA 173KG
UT WOS:000246871300010
PM 17496358
DA 2025-06-11
ER

PT J
AU Melamed, S
   Shirom, A
   Toker, S
   Berliner, S
   Shapira, I
AF Melamed, Samuel
   Shirom, Arie
   Toker, Sharon
   Berliner, Shlomo
   Shapira, Itzhak
TI Burnout and risk of cardiovascular disease: Evidence, possible causal
   paths, and promising research directions
SO PSYCHOLOGICAL BULLETIN
LA English
DT Review
DE burnout; stress; depression; cardiovascular disease
ID C-REACTIVE PROTEIN; CORONARY-HEART-DISEASE; PITUITARY-ADRENAL AXIS;
   ATHEROSCLEROTIC VASCULAR-DISEASE; CHRONIC-FATIGUE-SYNDROME;
   SELF-REPORTED HEALTH; ACUTE-PHASE PROTEINS; VITAL EXHAUSTION; METABOLIC
   SYNDROME; PSYCHOLOGICAL STRESS
AB Burnout is characterized by emotional exhaustion, physical fatigue, and cognitive weariness, resulting from prolonged exposure to work-related stress. The authors review the accumulated evidence suggesting that burnout and the related concept of vital exhaustion are associated with increased risk of cardiovascular disease and cardiovascular-related events. The authors present evidence supporting several potential mechanisms linking burnout with ill health, including the metabolic syndrome, dysregulation of the hypothalamic-pituitary-adrenal axis along with sympathetic nervous system activation, sleep disturbances, systemic inflammation, impaired immunity functions, blood coagulation and fibrinolysis, and poor health behaviors. The association of burnout and vital exhaustion with these disease mediators suggests that their impact on health may be more extensive than currently indicated.
C1 Tel Aviv Univ, Sackler Sch Med, Dept Epidemiol & Prevent Med, IL-69978 Tel Aviv, Israel.
   Tel Aviv Univ, Fac Management, Grad Program Org Behav, IL-69978 Tel Aviv, Israel.
   Tel Aviv Univ, Sackler Fac Med, IL-69978 Tel Aviv, Israel.
   Tel Aviv Sourasky Med Ctr, Dept Med D, Tel Aviv, Israel.
   Tel Aviv Sourasky Med Ctr, Inst Special Med Examinat, MALRAM, Tel Aviv, Israel.
C3 Tel Aviv University; Sackler Faculty of Medicine; Tel Aviv University;
   Tel Aviv University; Sackler Faculty of Medicine; Tel Aviv University;
   Sackler Faculty of Medicine; Tel Aviv Sourasky Medical Center; Tel Aviv
   University; Sackler Faculty of Medicine; Tel Aviv Sourasky Medical
   Center
RP Melamed, S (corresponding author), Tel Aviv Univ, Sackler Sch Med, Dept Epidemiol & Prevent Med, IL-69978 Tel Aviv, Israel.
EM smelamed@post.tau.ac.il
RI Toker, Sharon/P-5428-2015
OI Toker, Sharon/0000-0001-7621-6607
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NR 329
TC 614
Z9 793
U1 1
U2 140
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 0033-2909
EI 1939-1455
J9 PSYCHOL BULL
JI Psychol. Bull.
PD MAY
PY 2006
VL 132
IS 3
BP 327
EP 353
DI 10.1037/0033-2909.132.3.327
PG 27
WC Psychology; Psychology, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology
GA 046VM
UT WOS:000237839200001
PM 16719565
DA 2025-06-11
ER

PT J
AU Chyzhova, VP
   Korkushko, OV
   Shatylo, VB
   Pysaruk, AV
   Kuznietsov, VV
   Skrypchenko, OH
   Kovtonyuk, TI
   Samots, IA
AF Chyzhova, V. P.
   Korkushko, O. V.
   Shatylo, V. B.
   Pysaruk, A., V
   Kuznietsov, V. V.
   Skrypchenko, O. H.
   Kovtonyuk, T., I
   Samots, I. A.
TI Psychoemotional state and bioelectrical brain activity in patients of
   different ages with metabolic after COVID-19
SO ZAPOROZHYE MEDICAL JOURNAL
LA English
DT Article
DE psycho-emotional status; bioelectrical brain activity; COVID-19;
   metabolic syndrome; HADS scale; electro-encephalography
ID HOSPITAL ANXIETY; DEPRESSION SCALE
AB The aim of this study was to find out the impact of COVID-19 infection on the psycho-emotional state and bioelectrical brain activity in persons of different ages with metabolic syndrome. Material and methods. We examined 53 people who were divided into groups depending on age (40-59 years and 60 years and older) and status with regard to COVID-19 infection (contracted, not contracted). Patients had metabolic syndrome (ATP III), underwent comprehensive clinical and laboratory examinations, electroencephalography (an 18-channel electroencephalograph Nihon Kohden, Japan) and answered the Hospital Anxiety and Depression Scale (HADS) questionnaire. Results. Symptoms of anxiety or depression after COVID-19 were found in both age groups of MS. Anxiety symptoms were more often found in the group of 60 years and older. At the same time, subclinical anxiety was noted in persons of 60 years and older, while clinical anxiety - in middle-aged individuals. The latter also showed a trend towards an increase in clinically evident depression after COVID-19. Persons after COVID-19 with symptoms of anxiety or depression (according to the HADS scale) demonstrated changes in the frequency-amplitude indicators of the electroencephalogram (EEG) characterized by a power increase in the range of theta rhythm and accompanied by subclinical and clinical manifestations of depression. About 80 % of people who did not suffer from COVID-19 had normal EEG since 9 Hz alpha rhythm power was registered. In patients after COVID-19, there was a redistribution of alpha-rhythm power range: an increase in the ranges of alpha-1 rhythm and decrease in alpha-2 rhythm power as well as an increase in the delta and theta rhythm power range. Conclusions. 1-3 months following the acute period of COVID-19, the frequency of depression is 3 times higher in middle-aged patients with metabolic syndrome. In elderly patients with metabolic syndrome after COVID-19, anxiety is predominantly diag-nosed - almost in every second. These manifestations of anxiety and depression are accompanied by disorganization of the bioelectrical brain activity.
C1 [Chyzhova, V. P.; Korkushko, O. V.; Shatylo, V. B.; Kovtonyuk, T., I; Samots, I. A.] NAMS Ukraine, State Inst DF Chebotarev Inst Gerontol, Dept Clin Physiol & Pathol Internal Organs, Kiev, Ukraine.
   [Chyzhova, V. P.] NAMS Ukraine, State Inst DF Chebotarev Inst Gerontol, Gen Therapeut Dept, Kiev, Ukraine.
   [Korkushko, O. V.] NAMS Ukraine, Kiev, Ukraine.
   [Pysaruk, A., V] NAMS Ukraine, Lab Math Modeling Aging Proc, State Inst DF Chebotarev Inst Gerontol, Kiev, Ukraine.
   [Kuznietsov, V. V.] NAMS Ukraine, Dept Brain Vasc Pathol, State Inst DF Chebotarev Inst Gerontol, Kiev, Ukraine.
C3 National Academy of Medical Sciences of Ukraine; D. F. Chebotarev
   Institute of Gerontology of the National Academy of Medical Sciences of
   Ukraine; National Academy of Medical Sciences of Ukraine; D. F.
   Chebotarev Institute of Gerontology of the National Academy of Medical
   Sciences of Ukraine; National Academy of Medical Sciences of Ukraine;
   National Academy of Medical Sciences of Ukraine; D. F. Chebotarev
   Institute of Gerontology of the National Academy of Medical Sciences of
   Ukraine; National Academy of Medical Sciences of Ukraine; D. F.
   Chebotarev Institute of Gerontology of the National Academy of Medical
   Sciences of Ukraine
RP Chyzhova, VP (corresponding author), NAMS Ukraine, State Inst DF Chebotarev Inst Gerontol, Dept Clin Physiol & Pathol Internal Organs, Kiev, Ukraine.; Chyzhova, VP (corresponding author), NAMS Ukraine, State Inst DF Chebotarev Inst Gerontol, Gen Therapeut Dept, Kiev, Ukraine.
EM vchizhova@ukr.net
RI Kovtonyuk, Tetiana/JXY-4457-2024
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NR 25
TC 0
Z9 0
U1 0
U2 2
PU ZAPORIZHZHYA STATE MEDICAL UNIV
PI ZAPORIZHZHYA
PA PR-KT MAYAKOVSKOGO, 26, ZAPORIZHZHYA, 69035, UKRAINE
SN 2306-4145
EI 2310-1210
J9 ZAPOROZHYE MED J
JI ZAPOROZHYE MED. J.
PD MAY-JUN
PY 2023
VL 25
IS 3
BP 204
EP 214
DI 10.14739/2310-1210.2023.3.269483
PG 11
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA K3OA5
UT WOS:001015554500003
OA gold
DA 2025-06-11
ER

PT J
AU Shi, L
   Morrison, JA
   Wiecha, J
   Horton, M
   Hayman, LL
AF Shi, L.
   Morrison, J. A.
   Wiecha, J.
   Horton, M.
   Hayman, L. L.
TI Healthy lifestyle factors associated with reduced cardiometabolic risk
SO BRITISH JOURNAL OF NUTRITION
LA English
DT Article
DE Lifestyle; Cardiometabolic risk; Cross-sectional studies
ID CORONARY-HEART-DISEASE; METABOLIC SYNDROME; CARDIOVASCULAR EVENTS;
   PHYSICAL-ACTIVITY; BLOOD-PRESSURE; PRIMARY PREVENTION; PREVALENCE; DIET;
   DEPRESSION; MANAGEMENT
AB Minimal data are available regarding the cumulative effects of healthy lifestyle behaviours on cardiometabolic risk. The objective of the present study was to examine a combination of healthy lifestyle behaviours associated with cardiometabolic risk reduction. The analysis was based on a cross-sectional study of 1454 participants from the population-based Lipid Research Clinic's Princeton Follow-up Study. The healthy lifestyle factors included fruit and vegetable intake >= 5 servings/d, meat intake <= 2 servings/d, never smoking, consuming 2-6 alcoholic drinks/week, television (TV) viewing time <= 2 h/d and moderate to vigorous physical activity >= 4 h/week. The combination of healthy lifestyle behaviours was strongly and negatively associated with the presence of cardiometabolic risk, as well as with a composite cardiometabolic risk score after adjustment for race, age, generation and sex. With each additional healthy lifestyle factor, cardiometabolic risk decreased by 31% (OR 0.69; 95% CI 0.61, 0.78). A higher healthy lifestyle score was associated with a lower prevalence of cardiometabolic risk (P for trend, 0.001). Compared with individuals having 0-1 healthy lifestyle behaviours, those with 5 or 6 healthy lifestyle behaviours had a 70% lower prevalence of cardiometabolic risk (OR 0.30; 95% CI 0.13, 0.67). Healthy lifestyle behaviours including sufficient fruit and vegetable intake, less meat intake, less TV viewing time, abstinence from smoking, modest alcohol intake and regular exercise are associated with reduced cardiometabolic risk.
C1 [Shi, L.; Wiecha, J.; Horton, M.; Hayman, L. L.] Univ Massachusetts, Coll Nursing & Hlth Sci, Boston, MA 02125 USA.
   [Morrison, J. A.] Cincinnati Childrens Hosp Med Ctr, Cincinnati, OH 45229 USA.
C3 University of Massachusetts System; University of Massachusetts Boston;
   Cincinnati Children's Hospital Medical Center
RP Shi, L (corresponding author), Univ Massachusetts, Coll Nursing & Hlth Sci, 100 Morrissey Blvd, Boston, MA 02125 USA.
EM ling.shi@umb.edu
FU National Institutes of Health [HL62394]; University of Massachusetts
   Boston
FX L. S., J. A. M., J. W. and L. L. H. designed the study; L. S. performed
   the statistical analyses and wrote the manuscript; M. H. conducted the
   literature review; J. A. M., L. L. H. and J. W. edited the manuscript
   and helped with the interpretation and discussion of results. All
   authors approved the final manuscript. The authors do not have any
   conflicts of interest. The present study was supported by research grant
   HL62394 from the National Institutes of Health (J. A. M.) and the Joseph
   P. Healey from the University of Massachusetts Boston (L. S.).
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NR 41
TC 38
Z9 41
U1 0
U2 17
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1145
EI 1475-2662
J9 BRIT J NUTR
JI Br. J. Nutr.
PD MAR
PY 2011
VL 105
IS 5
BP 747
EP 754
DI 10.1017/S0007114510004307
PG 8
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 724WC
UT WOS:000287606000012
PM 21276278
OA Bronze
DA 2025-06-11
ER

PT J
AU Liu, Y
   Ozodiegwu, ID
   Yu, Y
   Hess, R
   Bie, RH
AF Liu, Ying
   Ozodiegwu, Ifeoma D.
   Yu, Yang
   Hess, Rick
   Bie, Ronghai
TI An association of health behaviors with depression and metabolic risks:
   Data from 2007 to 2014 US National Health and Nutrition Examination
   Survey
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Depression; Metabolic syndrome; Diet; Physical activity
ID OXIDATIVE STRESS; MAJOR DEPRESSION; BRAIN; METAANALYSIS; POPULATION;
   PREVALENCE; TRYPTOPHAN; DISORDER; EXERCISE; SMOKING
AB Background: Both depression and metabolic syndrome (MetS) confer an increased risk of developing type 2 diabetes (T2D) and cardiovascular disease. Accumulating evidence suggests healthy behaviors are crucial to maintain, improve and manage chronical disease and mental health; and unhealthy diet and sedentary behavior were found two major risk factors of MetS. The objective of this study was to investigate whether health behaviors (alcohol consumption, smoking, diet and recreational physical activity) are associated with depression and metabolic syndrome simultaneously.
   Methods: This study included 1300 participants aged 20 years and over who had answered mental health depression screener questions (PHQ-9) and finished examinations and laboratory tests related to five risk factors of MetS during the U.S. National Health and Nutrition Examination Survey (NHANES) 2007-2014. A set of series of weighted logistic regression models were used to investigate the aforementioned relationship.
   Results: The prevalence of depression among U.S. adults is 15.08%. The two most often reported depression symptoms were "Trouble sleeping or sleeping too much" and "Feeling tired or having little energy", with rates of 14.68% and 13.09%, respectively. Participants who engaged in only light physical activity were more likely to have been identified as experiencing depression and MetS than those who engaged in vigorous physical activity with odd ratios 3.18 (95% CI: 1.59, 6.37) and 3.50 (95%CI: 2.17, 5.63), respectively. Individuals in the study having poor diets were more likely to suffer from depression than those eating good diets (OR=2.17; 95%CI: 1.47, 3.22).
   Conclusion: Physical activity is strongly and inversely associated with depression and MetS. Diet is significantly associated with depression rather than MetS in this study.
C1 [Liu, Ying; Ozodiegwu, Ifeoma D.] East Tennessee State Univ, Dept Biostat & Epidemiol, Coll Publ Hlth, Johnson City, TN 37614 USA.
   [Yu, Yang] Henan Agr Univ, Inst Econ & Management, Zhengzhou, Henan, Peoples R China.
   [Hess, Rick] East Tennessee State Univ, Bill Gatton Coll Pharm, Johnson City, TN USA.
   [Bie, Ronghai] Henan Univ Chinese Med, Zhengzhou, Henan, Peoples R China.
C3 East Tennessee State University; Henan Agricultural University; East
   Tennessee State University; Henan University of Traditional Chinese
   Medicine
RP Liu, Y (corresponding author), East Tennessee State Univ, Dept Biostat & Epidemiol, Coll Publ Hlth, Johnson City, TN 37614 USA.
EM liuy09@etsu.edu
OI Ozodiegwu, Ifeoma D/0000-0001-7810-414X
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NR 38
TC 48
Z9 51
U1 1
U2 59
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD AUG
PY 2017
VL 217
BP 190
EP 196
DI 10.1016/j.jad.2017.04.009
PG 7
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA EY4YE
UT WOS:000403983200028
PM 28412644
DA 2025-06-11
ER

PT J
AU Bremner, JD
   Moazzami, K
   Wittbrodt, MT
   Nye, JA
   Lima, BB
   Gillespie, CF
   Rapaport, MH
   Pearce, BD
   Shah, AJ
   Vaccarino, V
AF Bremner, J. Douglas
   Moazzami, Kasra
   Wittbrodt, Matthew T.
   Nye, Jonathon A.
   Lima, Bruno B.
   Gillespie, Charles F.
   Rapaport, Mark H.
   Pearce, Bradley D.
   Shah, Amit J.
   Vaccarino, Viola
TI Diet, Stress and Mental Health
SO NUTRIENTS
LA English
DT Review
DE obesity; metabolic syndrome; serotonin; ghrelin; galanin; somatostatin;
   microbiome; brain; stress disorders; posttraumatic; child abuse;
   depressive disorder; diet; nutrition; cardiovascular disease; myocardial
   ischemia; coronary artery disease; Mediterranean diet
ID MAJOR DEPRESSIVE DISORDER; POLYUNSATURATED FATTY-ACIDS;
   CORONARY-HEART-DISEASE; QUALITY-OF-LIFE; RANDOMIZED CONTROLLED-TRIAL;
   SINGLE-UNIT RESPONSE; FREELY MOVING CATS; DOUBLE-BLIND; MEDITERRANEAN
   DIET; LOCUS-CERULEUS
AB Introduction: There has long been an interest in the effects of diet on mental health, and the interaction of the two with stress; however, the nature of these relationships is not well understood. Although associations between diet, obesity and the related metabolic syndrome (MetS), stress, and mental disorders exist, causal pathways have not been established. Methods: We reviewed the literature on the relationship between diet, stress, obesity and psychiatric disorders related to stress. Results: Diet and obesity can affect mood through direct effects, or stress-related mental disorders could lead to changes in diet habits that affect weight. Alternatively, common factors such as stress or predisposition could lead to both obesity and stress-related mental disorders, such as depression and posttraumatic stress disorder (PTSD). Specific aspects of diet can lead to acute changes in mood as well as stimulate inflammation, which has led to efforts to assess polyunsaturated fats (PUFA) as a treatment for depression. Bidirectional relationships between these different factors are also likely. Finally, there has been increased attention recently on the relationship between the gut and the brain, with the realization that the gut microbiome has an influence on brain function and probably also mood and behavior, introducing another way diet can influence mental health and disorders. Brain areas and neurotransmitters and neuropeptides that are involved in both mood and appetite likely play a role in mediating this relationship. Conclusions: Understanding the relationship between diet, stress and mood and behavior could have important implications for the treatment of both stress-related mental disorders and obesity.
C1 [Bremner, J. Douglas; Wittbrodt, Matthew T.; Gillespie, Charles F.; Rapaport, Mark H.] Emory Univ, Sch Med, Dept Psychiat, Atlanta, GA 30329 USA.
   [Bremner, J. Douglas; Wittbrodt, Matthew T.; Gillespie, Charles F.; Rapaport, Mark H.] Emory Univ, Sch Med, Dept Behav Sci, Atlanta, GA 30329 USA.
   [Bremner, J. Douglas; Nye, Jonathon A.] Emory Univ, Sch Med, Dept Radiol, Atlanta, GA 30332 USA.
   [Bremner, J. Douglas; Shah, Amit J.] Atlanta VA Med Ctr, Decatur, GA 30033 USA.
   [Moazzami, Kasra; Lima, Bruno B.; Shah, Amit J.; Vaccarino, Viola] Emory Univ, Sch Med, Dept Med Cardiol, Atlanta, GA 30332 USA.
   [Moazzami, Kasra; Lima, Bruno B.; Pearce, Bradley D.; Shah, Amit J.; Vaccarino, Viola] Emory Univ, Rollins Sch Publ Hlth, Dept Epidemiol, Atlanta, GA 30322 USA.
C3 Emory University; Emory University; Emory University; US Department of
   Veterans Affairs; Veterans Health Administration (VHA); Atlanta VA
   Medical Center; Atlanta VA Health Care System; Emory University; Emory
   University; Rollins School Public Health
RP Bremner, JD (corresponding author), Emory Univ, Sch Med, Dept Psychiat, Atlanta, GA 30329 USA.; Bremner, JD (corresponding author), Emory Univ, Sch Med, Dept Behav Sci, Atlanta, GA 30329 USA.; Bremner, JD (corresponding author), Emory Univ, Sch Med, Dept Radiol, Atlanta, GA 30332 USA.; Bremner, JD (corresponding author), Atlanta VA Med Ctr, Decatur, GA 30033 USA.
EM jdbremn@emory.edu; kmoazza@emory.edu; mwittbr@emory.edu; jnye@emory.edu;
   bruno.bezerra.lima@emory.edu; cgilles@emory.edu;
   mark.h.rapaport@emory.edu; bpearce@emory.edu; ajshah3@emory.edu;
   lvaccar@emory.edu
RI Gillespie, Charles/G-8481-2012; Vaccarino, Viola/AAW-5600-2020;
   Wittbrodt, Matt/AAW-3858-2020; Bremner, James/B-1632-2013; Lima,
   Bruno/AAB-2807-2021; Stefanadis, Christodoulos/ABH-2232-2020
OI Stefanadis, Christodoulos/0000-0001-5974-6454; Gillespie,
   Charles/0000-0001-5476-5920; Vaccarino, Laura Viola/0000-0002-9054-0654;
   Wittbrodt, Matthew/0000-0002-9533-8041; Bremner, James
   Douglas/0000-0003-1633-6433
FU NIH [R01 MH056120, R01 HL088726, K24 MH076955, P01 HL101398, T32
   MH067547, K24 HL077506, R01 HL068630, R01 HL109413, K23 HL127251, R01
   HL125246, S10 RR16917]
FX The work presented in this review was supported by grants from the NIH
   R01 MH056120, R01 HL088726, K24 MH076955, P01 HL101398, T32 MH067547,
   K24 HL077506, R01 HL068630, R01 HL109413, K23 HL127251, R01 HL125246,
   S10 RR16917.
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NR 232
TC 210
Z9 226
U1 28
U2 189
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD AUG
PY 2020
VL 12
IS 8
AR 2428
DI 10.3390/nu12082428
PG 27
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nutrition & Dietetics
GA OA6UF
UT WOS:000577916800001
PM 32823562
OA Green Published, gold
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Räikkönen, K
   Matthews, KA
   Kuller, LH
AF Räikkönen, K
   Matthews, KA
   Kuller, LH
TI The relationship between psychological risk attributes and the metabolic
   syndrome in healthy women:: Antecedent or consequence?
SO METABOLISM-CLINICAL AND EXPERIMENTAL
LA English
DT Article
ID CORONARY-HEART-DISEASE; MIDDLE-AGED WOMEN; PSYCHOSOCIAL FACTORS;
   PREMENOPAUSAL WOMEN; DEPRESSIVE SYMPTOMS; INSULIN-RESISTANCE; FAT
   DISTRIBUTION; ADIPOSE-TISSUE; BLOOD-PRESSURE; ARTERY-DISEASE
AB The metabolic syndrome is an important risk factor for major chronic diseases in women. A key component of the syndrome, central adiposity, is correlated with psychological risk factors associated with coronary artery disease in prior epidemiological studies. We evaluated if psychological risk factors predicted the metabolic syndrome and if the metabolic syndrome predicted psychological distress. A population-based cohort of 425 women who were middle-aged, and pre-, peri-, and postmenopausal was followed for an average 7.4 years. Psychological risk factors, including depression, anxiety, tension, current perceived stress, and anger, and biological components of the metabolic syndrome, including glucose, triglycerides, high-density lipoprotein (HDL)-cholesterol, waist circumference, and blood pressure (BP) were measured at baseline and at examinations 1 to 8 years postmenopause. Women were classified according to the National Heart, Lung, and Blood Institute (NHLBI) criteria for metabolic syndrome. Women who exhibited high levels of depression, tension, and anger at baseline, and increased in anger during the follow-up had elevated risk for developing the metabolic syndrome during follow-up, P < .04. The metabolic syndrome at baseline, in turn, predicted increasing anger and anxiety 7.4 years later, P < .001. Psychological risk factors affect the development of the metabolic syndrome. The association between anger and the metabolic syndrome is reciprocal. Reduction in the level of psychological distress may prevent the development of the metabolic syndrome in women. Copyright 2002, Elsevier Science (USA). All rights reserved.
C1 Univ Pittsburgh, Dept Psychiat, Sch Med, Pittsburgh, PA 15213 USA.
   Univ Helsinki, Dept Psychol, SF-00100 Helsinki, Finland.
   Univ Pittsburgh, Grad Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE); University
   of Pittsburgh; University of Helsinki; Pennsylvania Commonwealth System
   of Higher Education (PCSHE); University of Pittsburgh
RP Matthews, KA (corresponding author), Univ Pittsburgh, Dept Psychiat, Sch Med, 3811 Ohara St, Pittsburgh, PA 15213 USA.
OI Raikkonen, Katri/0000-0003-3124-3470
FU NHLBI NIH HHS [HL28266, HL65112, HL65111] Funding Source: Medline
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NR 40
TC 217
Z9 247
U1 0
U2 13
PU W B SAUNDERS CO
PI PHILADELPHIA
PA INDEPENDENCE SQUARE WEST CURTIS CENTER, STE 300, PHILADELPHIA, PA
   19106-3399 USA
SN 0026-0495
J9 METABOLISM
JI Metab.-Clin. Exp.
PD DEC
PY 2002
VL 51
IS 12
BP 1573
EP 1577
DI 10.1053/meta.2002.36301
PG 5
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism
GA 625YT
UT WOS:000179843700011
PM 12489070
DA 2025-06-11
ER

PT J
AU Lederman, O
   Rosenbaum, S
   Maloney, C
   Curtis, J
   Ward, PB
AF Lederman, Oscar
   Rosenbaum, Simon
   Maloney, Chris
   Curtis, Jackie
   Ward, Philip B.
TI Modifiable cardiometabolic risk factors in youth with at-risk mental
   states: A cross-sectional pilot study
SO PSYCHIATRY RESEARCH
LA English
DT Article
DE Physical activity; Exercise; Sleep; Mental illness; Psychosis;
   Cardiovascular disease; Diabetes; UHR; ARMS
ID PHYSICAL-ACTIVITY INTERVENTIONS; ULTRA-HIGH-RISK; CARDIORESPIRATORY
   FITNESS; SLEEP DURATION; SEDENTARY BEHAVIOR; PEOPLE; DEPRESSION;
   PSYCHOSIS; SCHIZOPHRENIA; CHILDREN
AB Young people experiencing psychotic illness engage in low amounts of physical activity have poor fitness levels and poor sleep quality. This study aimed to determine the prevalence of these modifiable cardiometabolic risk factors among individuals with at-risk mental states (ARMS), who are at increased risk of developing psychosis. A cross-sectional study was conducted in a community-based youth mental health service. Thirty participants (23%female, 21.3 +/- 1.7 years old) were recruited, 10 with ARMS, 10 with first-episode psychosis (FEP) and 10 healthy volunteers. Physical activity levels were assessed using self-report and objective measures. Aerobic capacity, upper body strength, hamstring flexibility, forearm grip strength and core endurance were assessed. Sleep quality, depression and anxiety were measured by self-report questionnaire. The ARMS group did not differ significantly on anthropometric measures from FEP or healthy volunteers. They engaged in significantly less physical activity (p < 0.05) and had poorer sleep quality (p < 0.05) than healthy volunteers. Our results are consistent with other studies that found that youth with ARMS are at greater cardiometabolic risk. Interventions aimed at improving these modifiable risk factors may assist with preventing the decline in physical health associated with the development of psychiatric illness.
C1 [Lederman, Oscar; Rosenbaum, Simon; Maloney, Chris] Univ New South Wales, Sch Med Sci, Sydney, NSW, Australia.
   [Rosenbaum, Simon; Curtis, Jackie; Ward, Philip B.] Univ New South Wales, Sch Psychiat, Sydney, NSW, Australia.
   [Lederman, Oscar; Curtis, Jackie] South Eastern Sydney Local Hlth Dist, Keeping Body Mind Program, Sydney, NSW, Australia.
   [Ward, Philip B.] South Western Sydney Local Hlth Dist, Schizophrenia Res Unit, Liverpool, NSW, Australia.
   [Ward, Philip B.] Ingham Inst Appl Med Res, Liverpool, NSW, Australia.
C3 University of New South Wales Sydney; University of New South Wales
   Sydney; South Eastern Sydney Local Health District; South Western Sydney
   Local Health District; Ingham Institute for Applied Medical Research
RP Lederman, O (corresponding author), Keeping Body Mind Program, 26 Llandaff St Bondi Junct, Sydney, NSW 2022, Australia.
EM Oscar.Lederman@health.nsw.gov.au
RI Curtis, Jackie/J-5789-2019; Rosenbaum, Simon/Y-3241-2019; Maloney,
   Christopher/AAG-8599-2019; Ward, Philip/JCE-6293-2023
OI Lederman, Oscar/0000-0002-0321-5723; Ward, Philip/0000-0002-5779-7722;
   Rosenbaum, Simon/0000-0002-8984-4941; Maloney,
   Christopher/0000-0002-9193-2369; Curtis, Jackie/0000-0001-6884-0098
FU NHMRC Early Career Fellowship [APP1123336]; UNSW Scientia Fellowship
FX The authors would like to thank the staff and consumers of the Youth
   Mental Health team and Early Psychosis Program at the Bondi Community
   Health Centre, Sydney, Australia for their assistance and participation
   in this study. We acknowledge the South Eastern Sydney Local Health
   District Mental Health Service for supporting the service wide
   implementation of the Keeping the Body in Mind teams. SR is funded an
   NHMRC Early Career Fellowship (APP1123336) and UNSW Scientia Fellowship.
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NR 59
TC 13
Z9 14
U1 0
U2 10
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0165-1781
EI 1872-7123
J9 PSYCHIAT RES
JI Psychiatry Res.
PD NOV
PY 2017
VL 257
BP 424
EP 430
DI 10.1016/j.psychres.2017.08.034
PG 7
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA FK3KZ
UT WOS:000413385300069
PM 28837931
DA 2025-06-11
ER

PT J
AU Akbari, H
   Sarrafzadegan, N
   Aria, H
   Garaei, AG
   Zakeri, H
AF Akbari, Hamed
   Sarrafzadegan, Nizal
   Aria, Hamid
   Garaei, Alireza Gholami
   Zakeri, Habib
TI Anxiety but not depression is associated with metabolic syndrome: The
   Isfahan healthy heart program
SO JOURNAL OF RESEARCH IN MEDICAL SCIENCES
LA English
DT Article
DE Anxiety; depression; Iran; metabolic syndrome
ID CARDIOVASCULAR-DISEASE; WAIST CIRCUMFERENCE; RISK; PREVALENCE; SYMPTOMS;
   POPULATION; WOMEN; LUNG; LIFE
AB Background: Only a few studies have carried out to evaluate the association of depression and anxiety with metabolic syndrome (MetS). The aim of this study was to investigate whether the depression and anxiety are associated with MetS and its different components. Materials and Methods: This cross-sectional study forms part of the prospective Isfahan Cohort Study. A total of 470 participants were chosen. Anxiety and depression symptoms were measured using hospital anxiety and depression scale (HADS). The MetS was diagnosed according to the American Heart Association and National Heart, Lung, and Blood Institute. One-way analysis of variance and binary logistic regression were used. Results: The mean age of participants was 55.7 9.3. The prevalence of MetS in female participants with symptoms of depression (P < 0.0001), concurrent anxiety and depression (P = 0.004), anxiety (P < 0.0001), and asymptomatic individuals (P = 0.001) was significantly different when compared to male participants. Moreover, the analysis showed that having anxiety symptoms is in a negative relationship with MetS (odds ratio [OR] = 0.31; 95% confidence interval [CI] = 0.12-0.78). In addition, with each 10-year increase in age, the probability of MetS will decrease 40% (OR = 0.59; 95%Cl = 0.53-0.72). Body mass index (OR = 1.29; 95%CI = 1.21-1.37), and gender (higher age for women) (OR = 0.34; 95%CI = 0.11-0.98) had positive relationship with MetS. Conclusion: The study findings revealed that the prevalence of MetS in patients with anxiety was lower than the healthy subjects, while no significant association was found between depression, concurrent depression, an anxiety with MetS.
C1 [Akbari, Hamed] Endocrinol & Metab Res Ctr, Inst Basic & Clin Physiol Sci, Tehran, Iran.
   [Akbari, Hamed] Kerman Univ Med Sci, Sch Med, Student Res Comm, Kerman, Iran.
   [Sarrafzadegan, Nizal] Isfahan Univ Med Sci, Isfahan Cardiovasc Res Inst, Isfahan Cardiovasc Res Ctr, Esfahan, Iran.
   [Aria, Hamid] Shiraz Univ Med Sci, Dept Immunol, Shiraz, Iran.
   [Garaei, Alireza Gholami] Fasa Univ Med Sci, Sch Med, Student Res Comm, Fasa, Iran.
   [Zakeri, Habib] Fasa Univ Med Sci, Dept Anesthesiol, Fasa, Iran.
C3 Tehran University of Medical Sciences; Kerman University of Medical
   Sciences; Isfahan University of Medical Sciences; Shiraz University of
   Medical Science
RP Zakeri, H (corresponding author), Fasa Univ Med Sci, Dept Anesthesiol, Fasa, Iran.
EM zakerihabib@gmail.com
RI Akbari, Hamed/B-5923-2018; Zakeri, Habibollah/N-2431-2017;
   Sarrafzadegan, Nizal/V-5826-2017
OI Akbari, Hamed/0000-0002-9939-6652; Zakeri,
   Habibollah/0000-0003-2495-8507; Sarrafzadegan, Nizal/0000-0002-8352-0540
CR [Anonymous], 2006, PREV CONTROL, DOI DOI 10.1016/J.PRECON.2006.10.003
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NR 34
TC 16
Z9 16
U1 0
U2 4
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, 400059, INDIA
SN 1735-1995
EI 1735-7136
J9 J RES MED SCI
JI J. Res. Med. Sci.
PD JUL
PY 2017
VL 22
AR 90
DI 10.4103/jrms.JRMS_288_16
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA FF8OL
UT WOS:000409277600009
PM 28919917
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Rioli, G
   Mattei, G
   Bursi, S
   Padula, MS
   Pingani, L
   Ferrari, S
   Galeazzi, GM
AF Rioli, Giulia
   Mattei, Giorgio
   Bursi, Serena
   Padula, Maria Stella
   Pingani, Luca
   Ferrari, Silvia
   Galeazzi, Gian M.
TI Association between anxious-depressive symptoms and metabolic syndrome
   and its single components: an Italian cross-sectional study among
   primary care outpatients
SO MINERVA PSYCHIATRY
LA English
DT Article
DE & nbsp; Anxiety; Depression; Metabolic syndrome; Comorbidity;
   Outpatients
ID HOSPITAL ANXIETY; PSYCHOLOGICAL DISTRESS; MENTAL-DISORDERS;
   YOUNG-ADULTS; PREVALENCE; MOOD; METAANALYSIS; EMPLOYMENT; VALIDITY;
   STRESS
AB BACKGROUND: The association between anxious-depressive disorders and Metabolic Syndrome (MetS) has been sel-dom addressed in literature, despite being common in clinical practice, and with mixed results. Aim of this study was to measure prevalence and association of symptoms of anxiety and/or depression with MetS and its single components among primary care patients. METHODS: Cross-sectional study. The Hospital Anxiety and Depression Scale (HADS) was used to measure symptoms of anxiety and/or depression. RESULTS: Among 210 primary care outpatients (60% women), 84 (40%) had symptoms of anxiety, 30 (14.29%) had depressive symptoms and 26 (12.38%) had anxious-depressive symptoms; 66 patients (31.43% of the total sample) had MetS according to the Adult Treatment Panel III (ATPIII) definition, and 69 (37.62%) according to International Diabetes Federation (IDF) criteria. Anxious (P<0.01), depressive (P<0.01) and comorbid anxious-depressive (P<0.01) symptoms were significantly prevalent in female vs. male patients. At the multivariate logistic regression analysis, symptoms of anxiety were inversely associated to employment status (OR=0.28, P=0.04), and positively associated to waist circum-ference (ATPIII criteria) (OR=2.07, P=0.03); both depressive (OR=0.17, P<0.01) and anxious-depressive symptoms (OR=0.20, P<0.01) were inversely associated to educational level. CONCLUSIONS: At the regression analysis, a positive association was found between waist circumference, a key com-ponent of MetS, and anxiety symptoms, suggesting the need to clinically manage these two dimensions in a coordinated way. Further research is needed to better understand the causative pathways of this correlation.
C1 [Rioli, Giulia] Univ Modena & Reggio Emilia, Dept Biomed Metab & Neural Sci, PhD Program Clin & Expt Med, Via Giuseppe campi 287, I-41125 Modena, Italy.
   [Rioli, Giulia; Pingani, Luca; Ferrari, Silvia; Galeazzi, Gian M.] Azienda USL IRCSS Reggio Emilia, Dept Mental Hlth & Pathol Addict, Reggio Emilia, Italy.
   [Mattei, Giorgio] Assoc Res Psychiat, Castelnuovo Rangone, Modena, Italy.
   [Bursi, Serena] Azienda USL IRCSS Reggio Emilia, Operat Unit Endocrinol, Reggio Emilia, Italy.
   [Padula, Maria Stella] Univ Modena & Reggio Emilia, Dept Gen Practice Primary Care, Modena, Italy.
   [Pingani, Luca; Ferrari, Silvia; Galeazzi, Gian M.] Univ Modena & Reggio Emilia, Dept Biomed Metab & Neural Sci, Sect Clin Neurosci, Modena, Italy.
C3 Universita di Modena e Reggio Emilia; Universita di Modena e Reggio
   Emilia; Universita di Modena e Reggio Emilia
RP Rioli, G (corresponding author), Univ Modena & Reggio Emilia, Dept Biomed Metab & Neural Sci, PhD Program Clin & Expt Med, Via Giuseppe campi 287, I-41125 Modena, Italy.
EM giulyrioli@hotmail.it
RI Galeazzi, Gian Maria/J-6676-2016; PINGANI, LUCA/AAW-5196-2020; Ferrari,
   Silvia/G-5964-2011
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NR 46
TC 0
Z9 0
U1 0
U2 0
PU EDIZIONI MINERVA MEDICA
PI TURIN
PA CORSO BRAMANTE 83-85 INT JOURNALS DEPT., 10126 TURIN, ITALY
SN 2724-6612
EI 2724-6108
J9 MINERVA PSYCHIAT
JI Minerva Psychiat.
PD JUN
PY 2023
VL 64
IS 2
BP 97
EP 105
DI 10.23736/S2724-6612.22.02315-6
PG 9
WC Psychiatry
WE Emerging Sources Citation Index (ESCI)
SC Psychiatry
GA M1RA5
UT WOS:001027999300001
DA 2025-06-11
ER

PT J
AU Lubas, MM
   Wang, MJ
   Jefferies, JL
   Ness, KK
   Ehrhardt, MJ
   Krull, KR
   Mulrooney, DA
   Srivastava, DK
   Howell, RM
   Robison, LL
   Hudson, MM
   Armstrong, GT
   Brinkman, TM
AF Lubas, Margaret M.
   Wang, Mingjuan
   Jefferies, John L.
   Ness, Kirsten K.
   Ehrhardt, Matthew J.
   Krull, Kevin R.
   Mulrooney, Daniel A.
   Srivastava, Deo Kumar
   Howell, Rebecca M.
   Robison, Leslie L.
   Hudson, Melissa M.
   Armstrong, Gregory T.
   Brinkman, Tara M.
TI The Contribution of Stress and Distress to Cardiovascular Health in
   Adult Survivors of Childhood Cancer
SO CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
LA English
DT Article
ID ACUTE CORONARY SYNDROME; POSTTRAUMATIC-STRESS; RISK-FACTORS; DEPRESSIVE
   SYMPTOMS; METABOLIC SYNDROME; DISORDER SYMPTOMS; PERCEIVED STRESS;
   CARDIAC OUTCOMES; LATE MORTALITY; HEART-DISEASE
AB Background: Childhood cancer survivors are at risk for cardiovascular morbidity and mortality that is not fully explained by cancer-directed therapies. We examined the contribution of emotional stress and distress to cardiac health in adult survivors of childhood cancer.
   Methods: Participants included 3,267 adult survivors enrolled in the St. Jude Lifetime Cohort Study [median (range) 29.9 (18.1-64.5) years of age; 7.7 (0-24.8) years at diagnosis; 48.4% female]. Survivors completed comprehensive medical assessments and standardized measures of depression, anxiety, posttrauma tic stress symptoms (PTSS), and perceived stress. Cardiovascular-related conditions included hypertension, diabetes, dyslipidemia, cardiomyopathy, dysrhythmia, myocardial infarction (severity graded 0-4), and metabolic syndrome (yes/no). Multivariable modified Poisson models examined associations between symptoms of stress/distress and cardiovascular outcomes. Longitudinal associations between stress/distress and new-onset cardiovascular outcomes, defined as a change from grade <= 1 at initial evaluation to grade >= 2 at follow-up (median 3.9 years) were examined in 1,748 participants.
   Results: In multivariable cross-sectional models, stress/distress was associated with hypertension [risk ratio (RR) = 1.24; 95% confidence interval (CI), 1.07-1.43], dyslipidemia (RR = 1.29; 95% CI, 1.03-1.61), and metabolic syndrome (RR = 1.35; 95% CI, 1.17-1.54) independent of known cardiovascular risk factors. In longitudinal models, stress/distress was associated with new-onset dysrhythmia (RR - 2.87; 95% CI, 1.21-6.78), perceived stress with hypertension (RR = 1.42; 95% CI, 1.04-1.95), and PTSS and anxiety with dyslipidemia (RR - 1.72; 95% CI, 1.13-2.62; RR - 1.54; 95% CI, I .01-2.35, respectively).
   Conclusions: Stress/distress is independently associated with adverse cardiovascular outcomes among childhood cancer survivors.
   Impact: Improving psychological health may serve as a potential intervention target for optimizing cardiac health among childhood cancer survivors.
C1 [Lubas, Margaret M.; Ness, Kirsten K.; Ehrhardt, Matthew J.; Krull, Kevin R.; Mulrooney, Daniel A.; Robison, Leslie L.; Hudson, Melissa M.; Armstrong, Gregory T.; Brinkman, Tara M.] St Jude Childrens Res Hosp, Dept Epidemiol & Canc Control, Memphis, TN 38105 USA.
   [Wang, Mingjuan; Srivastava, Deo Kumar] St Jude Childrens Res Hosp, Dept Biostat, Memphis, TN 38105 USA.
   [Jefferies, John L.] Univ Tennessee, Hlth Sci Ctr, Div Cardiovasc Dis, Memphis, TN USA.
   [Ehrhardt, Matthew J.; Mulrooney, Daniel A.; Hudson, Melissa M.; Armstrong, Gregory T.] St Jude Childrens Res Hosp, Dept Oncol, Memphis, TN 38105 USA.
   [Krull, Kevin R.; Brinkman, Tara M.] St Jude Childrens Res Hosp, Dept Psychol, Memphis, TN 38105 USA.
   [Howell, Rebecca M.] Univ Texas MD Anderson Canc Ctr, Dept Radiat Phys, Houston, TX 77030 USA.
C3 St Jude Children's Research Hospital; St Jude Children's Research
   Hospital; University of Tennessee System; University of Tennessee Health
   Science Center; St Jude Children's Research Hospital; St Jude Children's
   Research Hospital; University of Texas System; UTMD Anderson Cancer
   Center
RP Brinkman, TM (corresponding author), St Jude Childrens Res Hosp, 262 Danny Thomas Pl,MS 735, Memphis, TN 38105 USA.
EM tara.brinkman@stjude.org
RI Robison, Leslie/N-8122-2018; Jefferies, John/JDV-5221-2023; Ness,
   Kirsten/N-2550-2018; Brinkman, Tara/N-8171-2018; Armstrong,
   Gregory/N-8096-2018; hayashi, robert/AAH-2077-2019; Ehrhardt,
   Matt/N-3105-2018; Krull, Kevin/N-3882-2018
OI Krull, Kevin/0000-0002-0476-7001
FU NCI [U01 CA195547, T32 CA225590]; American Lebanese Syrian Associated
   Charities (ALSAC); National Cancer Institute [U01CA195547] Funding
   Source: NIH RePORTER
FX This study was supported by the NCI (U01 CA195547, to M.M. Hudson and
   L.L. Robison, principal investigators; and T32 CA225590, to K.R. Krull,
   principal investigator). Support to St. Jude Children's Research
   Hospital was also provided by the American Lebanese Syrian Associated
   Charities (ALSAC).
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NR 56
TC 7
Z9 8
U1 0
U2 5
PU AMER ASSOC CANCER RESEARCH
PI PHILADELPHIA
PA 615 CHESTNUT ST, 17TH FLOOR, PHILADELPHIA, PA 19106-4404 USA
SN 1055-9965
EI 1538-7755
J9 CANCER EPIDEM BIOMAR
JI Cancer Epidemiol. Biomarkers Prev.
PD FEB
PY 2021
VL 30
IS 2
BP 286
EP 294
DI 10.1158/1055-9965.EPI-20-1183
PG 9
WC Oncology; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Oncology; Public, Environmental & Occupational Health
GA QF0VX
UT WOS:000616619800008
PM 33234555
OA Bronze, Green Accepted
DA 2025-06-11
ER

PT J
AU Shin, Y
   Kim, Y
AF Shin, Yoonjin
   Kim, Yangha
TI Psychological Stress Accompanied by a Low-Variety Diet Is Positively
   Associated with Type 2 Diabetes in Middle-Aged Adults
SO NUTRIENTS
LA English
DT Article
DE psychological stress; type 2 diabetes; dietary variety score;
   low-variety diet
ID PERCEIVED STRESS; DIVERSITY SCORE; METABOLIC SYNDROME; LIFE-STYLE;
   FOLLOW-UP; RISK; POPULATION; PREVALENCE; DEPRESSION; NUTRITION
AB Psychological stress is generally known to affect dietary intakes and cause chronic diseases. This study aims to investigate the association between psychological stress and the risk of type 2 diabetes in relation to dietary variety. A total of 126,405 middle-aged adults were enrolled in the Korean Genome and Epidemiology Study. Stress levels were measured using the psychosocial well-being index. Dietary variety score (DVS) was defined as the number of different foods consumed over a day. Stress levels were positively associated with the risks of diabetes (odds ratio (OR) for tertile 3 compared with tertile 1, men: OR = 1.34 (95% CI: 1.24-1.45); women: OR = 1.29 (1.19-1.4)). As the stress levels rose, the intake of grains increased, and the intake of fruits and vegetables decreased. Participants with higher stress levels showed lower DVS than those with lower stress levels. Furthermore, participants with higher stress levels and lower DVS had a significantly higher OR for diabetes than those with lower stress levels and higher DVS (men: OR = 1.83 (1.58-2.12); women: OR = 1.85 (1.59-2.51)). These results suggest that the high risk of type 2 diabetes for people with high stress levels may be associated with low dietary variety.
C1 [Shin, Yoonjin; Kim, Yangha] Ewha Womans Univ, Dept Nutr Sci & Food Management, Seoul 03760, South Korea.
C3 Ewha Womans University
RP Kim, Y (corresponding author), Ewha Womans Univ, Dept Nutr Sci & Food Management, Seoul 03760, South Korea.
EM yjin19@hotmail.com; yhmoon@ewha.ac.kr
OI Kim, Yangha/0000-0002-7280-7597; Shin, Yoonjin/0000-0002-5633-9607
FU National Research Foundation of Korea (NRF) - Korean Government (MSIT)
   [2012M3A9C4048761, 2019R1C1C1002649]
FX This study was supported by the National Research Foundation of Korea
   (NRF) funded by the Korean Government (MSIT) (No. 2012M3A9C4048761 and
   2019R1C1C1002649).
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NR 38
TC 6
Z9 6
U1 0
U2 11
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD SEP
PY 2020
VL 12
IS 9
AR 2612
DI 10.3390/nu12092612
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nutrition & Dietetics
GA OF6HK
UT WOS:000581306000001
PM 32867193
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Stefkova, G
   Zamboriova, M
AF Stefkova, Gabriela
   Zamboriova, Maria
TI Metabolic Syndrome and Mental Health in the Time of Covid-19 Pandemic
SO CLINICAL SOCIAL WORK AND HEALTH INTERVENTION
LA English
DT Article
DE COVID-19 Pandemic; Metabolic Syndrome; Mental Illnesses
ID ILLNESS
AB Introduction. At the end of 2019, China was hit by a disease with pandemic potential. It was a new coronavirus, also called COVID-19 (coronavirus disease). In March 2020, the World Health Organization (WHO) declared the situation a pandemic. Those most at risk were people with metabolic syndrome, mentally ill and the elderly. Metabolic syndrome (MetS) and its components have become a monitored issue in the context of mental illnesses. The COVID-19 pandemic, metabolic syndrome, and mental health have become interrelated. The number of mental illnesses has grown exponentially around the world, having affected several age groups.
   Methodology. A search and selection of articles from the online scientific database WOS through bibliometric analysis, using the keywords "COVID-19", "metabolic syndrome", "mental illnesses" in the period from 2020 to 2021 to present the relationships between metabolic syndrome and mental illnesses during the COVID-19 pandemic.
   Conclusion. In the area of publications, the issue of depression during the COVID-19 pandemic was the most watched topic. A higher incidence of metabolic syndrome or its components has been reported in patients suffering from mental illnesses.
C1 [Stefkova, Gabriela; Zamboriova, Maria] Pavol Jozef Safarik Univ, Dept Nursing Care, Fac Med, Kosice, Slovakia.
C3 University of Pavol Jozef Safarik Kosice
RP Stefkova, G (corresponding author), Pavol Jozef Safarik Univ, Dept Nursing Care, Fac Med, Kosice, Slovakia.
EM gabriela.stefkova@upjs.sk
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NR 33
TC 1
Z9 1
U1 2
U2 10
PU INT SCIENTIFIC GROUP APPLIED PREVENTIVE MEDICINE I-GAP EV
PI WIEN
PA WAHRINGER STR 63, WIEN, A-1090, AUSTRIA
SN 2222-386X
EI 2076-9741
J9 CLIN SOC WORK HEALTH
JI Clin. Soc. Work Health Interv.
PY 2021
VL 12
IS 5
BP 15
EP 21
DI 10.22359/cswhi_12_5_02
PG 7
WC Public, Environmental & Occupational Health
WE Emerging Sources Citation Index (ESCI)
SC Public, Environmental & Occupational Health
GA YX8VZ
UT WOS:000754375000003
DA 2025-06-11
ER

PT J
AU Kim, B
   Park, EY
AF Kim, B.
   Park, E. Y.
TI The combined effect of socioeconomic status and metabolic syndrome on
   depression: the Korean National Health and Nutrition Examination Survey
   (KNHANES)
SO BMC PUBLIC HEALTH
LA English
DT Article
DE Social environment; Metabolism; Depression; Mental health
ID YOUNG-ADULTS; HEART-DISEASE; SYMPTOMS; ASSOCIATION; HYPERTENSION;
   PATHOGENESIS; DISORDER; ANXIETY; OBESITY; STRESS
AB BackgroundDepression shows different patterns depending on socioeconomic status (SES) and metabolic syndrome (MS). However, the nature of this association remains poorly understood. The aim of this study was to examine whether the combination of MS and lower SES was associated with the prevalence of depression, based on data from the Korea National Health and Nutrition Examination Survey (KNHANES).MethodsData were obtained from a cross-sectional study of 24,102 adults (>19years of age) who participated in the KNHANES during 2008-2013 and for whom MS and depression data were available. MS was defined using the diagnostic criteria of the modified National Cholesterol Education Program Adult Treatment Panel III. Measure of depression was ascertained from self-reports of physician diagnosis. Multiple logistic regression analysis was used to evaluate the association between depression and MS as well as SES (alone and in combination).ResultsOverall, 622 of the 24,102 subjects (2.6%) met the criteria for depression. The prevalence of depression was associated with MS, a lower high-density lipoprotein cholesterol level, an elevated triglyceride level, a lower education level, and a lower household income. Participants with MS and a low SES had a higher likelihood of depression than those without MS and a high SES (odds ratio [OR]=4.180 for low education level and OR=3.994 for low household income level).ConclusionsThis study suggests that the combination of SES and MS may play an important role in depression, which has implications for healthcare policy and depression management.
C1 [Kim, B.; Park, E. Y.] Natl Canc Ctr, Natl Canc Control Inst, Div Canc Prevent & Early Detect, 323 Ilsan Ro, Goyang Si 10408, Gyeonggi Do, South Korea.
C3 National Cancer Center - Korea (NCC)
RP Park, EY (corresponding author), Natl Canc Ctr, Natl Canc Control Inst, Div Canc Prevent & Early Detect, 323 Ilsan Ro, Goyang Si 10408, Gyeonggi Do, South Korea.
EM goajoa@ncc.re.kr
RI Kim, Byung-Hak/AAY-9891-2020
OI Kim, Byungmi/0000-0001-8621-9190
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NR 47
TC 10
Z9 10
U1 0
U2 4
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2458
J9 BMC PUBLIC HEALTH
JI BMC Public Health
PD MAY 4
PY 2020
VL 20
IS 1
DI 10.1186/s12889-020-08778-3
PG 12
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA LM5PH
UT WOS:000532300300005
PM 32366283
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Wynaden, D
   Barr, L
   Omari, O
   Fulton, A
AF Wynaden, Dianne
   Barr, Lesley
   Omari, Omar
   Fulton, Anthony
TI Evaluation of service users' experiences of participating in an exercise
   programme at the Western Australian State Forensic Mental Health
   Services
SO INTERNATIONAL JOURNAL OF MENTAL HEALTH NURSING
LA English
DT Article
DE exercise; forensic mental health; physical health; psychosis
ID PHYSICAL HEALTH; METABOLIC SYNDROME; MAJOR DEPRESSION; RISK-FACTORS;
   PEOPLE; SCHIZOPHRENIA; MANAGEMENT; MORTALITY; ILLNESS; LIFE
AB Approximately 210 patients are admitted each year to the Western Australian State Forensic Mental Health Service, and most present with psychotic illness, along with other physical and mental comorbidities. In 2010, a healthy lifestyle programme, which included a formal exercise programme coordinated by an exercise physiologist, was sintroduced at the service. A self-report questionnaire was developed to obtain feedback on the programme, and 56 patients completed the quetionnaire during the 6-month evaluation period. As well as providing patients with access to regular physical activity, the programme also supports the recovery philosophy, where patients work in partnership with forensic mental health staff. Overall, patients reported that the programme assisted them to manage their psychiatric symptoms, as well as improving their level of fitness, confidence, and self-esteem. In addition, patients received education about the importance of regular exercise to their mental health, and the role exercise plays in preventing chronic illness and obesity. While the benefits of exercise on mental health outcomes for people with depression and anxiety are well established, this evaluation adds to the evidence that such programmes provide similar benefits to people who have a psychotic illness and are hospitalized in an acute secure setting.
C1 [Wynaden, Dianne] Curtin Univ, Curtin Hlth Innovat Res Inst, State Forens Mental Hlth Serv, Perth, WA 6845, Australia.
C3 Curtin University
RP Wynaden, D (corresponding author), Curtin Univ, Curtin Hlth Innovat Res Inst, State Forens Mental Hlth Serv, GPO Box U 1987, Perth, WA 6845, Australia.
EM d.wynaden@curtin.edu.au
RI Al Omari, Omar/I-7784-2019; Barr, Lesley/M-4796-2018
OI Al Omari, Omar/0000-0002-7614-1729; Wynaden, Dianne/0000-0002-3985-7621;
   Barr, Lesley/0000-0002-6617-6960
CR Australian Institute of Health and Wellbeing, 2008, AB TORR STRAIT ISL H
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NR 36
TC 24
Z9 28
U1 0
U2 26
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1445-8330
EI 1447-0349
J9 INT J MENT HEALTH NU
JI Int. J. Ment. Health Nurs.
PD JUN
PY 2012
VL 21
IS 3
SI SI
BP 229
EP 235
DI 10.1111/j.1447-0349.2011.00787.x
PG 7
WC Nursing; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Psychiatry
GA 931RS
UT WOS:000303237600006
PM 22533330
DA 2025-06-11
ER

PT J
AU Mayolas-Pi, C
   Simón-Grima, J
   Peñarrubia-Lozano, C
   Munguía-Izquierdo, D
   Moliner-Urdiales, D
   Legaz-Arrese, A
AF Mayolas-Pi, Carmen
   Simon-Grima, Javier
   Penarrubia-Lozano, Carlos
   Munguia-Izquierdo, Diego
   Moliner-Urdiales, Diego
   Legaz-Arrese, Alejandro
TI Exercise addiction risk and health in male and female amateur endurance
   cyclists
SO JOURNAL OF BEHAVIORAL ADDICTIONS
LA English
DT Article
DE risk of exercise addiction; endurance training; physical activity;
   health; quality of life; quality of sleep
ID SLEEP QUALITY INDEX; NICOTINE DEPENDENCE; PHYSICAL-ACTIVITY;
   PSYCHOMETRIC PROPERTIES; CARDIOVASCULAR-DISEASE; BEHAVIORAL ADDICTIONS;
   COMPULSIVE EXERCISE; SPANISH VERSION; FAGERSTROM TEST; VALIDATION
AB Background and aims: To determine the relationship between the risk of exercise addiction (REA) and health status in amateur endurance cyclists. Methods: In 859 (751 men and 108 women) cyclists and 718 inactive subjects (307 men and 411 women), we examined the REA (Exercise Addiction Inventory), training status (volume, frequency, experience, and performance), socioeconomic status, quality of life (QoL) (SF-12), quality of sleep (Pittsburgh Sleep Quality Index), anxiety and depression (Hospital Anxiety and Depression Scale), and cardiometabolic risk: body mass index, physical activity (International Physical Activity Questionnaire), physical condition (International Fitness Scale), adherence to the Mediterranean diet (Mediterranean Diet Adherence Screener), alcohol and tobacco consumption. Results: In total, 17% of the cyclists showed evidence of REA and 83% showed low REA. REA occurred independent of age, sex, training, and socioeconomic status (all ps > .05). Regardless of REA, the cyclists displayed a better physical QoL and a lower cardiometabolic risk than the inactive subjects (all ps < .05). The cyclists with REA displayed worse values of mental QoL, quality of sleep, and anxiety than cyclists with low REA (all ps < .05). The REA group had better values of mental QoL and anxiety and similar values of quality of sleep than the inactive subjects. The differences in mental QoL between the REA and low REA groups were significantly greater in women (p = .013). There was no Addiction x Sex interaction in the other analyzed variables. Conclusion: Our results suggest that an increased prevalence of REA limits the benefits that amateur endurance cycling has on mental health and quality of sleep.
C1 [Mayolas-Pi, Carmen; Simon-Grima, Javier; Legaz-Arrese, Alejandro] Univ Zaragoza, Sect Phys Educ & Sports, Calle Domingo Miral S-N, E-50009 Zaragoza, Spain.
   [Penarrubia-Lozano, Carlos] Univ Zaragoza, Dept Mus Plast & Corporal Express, Zaragoza, Spain.
   [Munguia-Izquierdo, Diego] Univ Pablo de Olavide, Sect Phys Educ & Sports, Dept Sports & Comp Sci, Seville, Spain.
   [Moliner-Urdiales, Diego] Univ Jaume 1, Dept Educ, Castellon de La Plana, Spain.
C3 University of Zaragoza; University of Zaragoza; Universidad Pablo de
   Olavide; Universitat Jaume I
RP Mayolas-Pi, C (corresponding author), Univ Zaragoza, Sect Phys Educ & Sports, Calle Domingo Miral S-N, E-50009 Zaragoza, Spain.
EM carmayo@unizar.es
RI Munguía-Izquierdo, Diego/H-6452-2013; Peñarrubia-Lozano,
   Carlos/L-7068-2018; Mayolas-Pi, Carmen/Y-2652-2018; Moliner-Urdiales,
   Diego/H-8689-2013; Simón, Javier/IST-5663-2023; Legaz Arrese,
   Alejandro/H-8702-2013
OI Mayolas Pi, Carmen/0000-0003-0721-2447; Penarrubia Lozano,
   Carlos/0000-0002-3776-2901; Moliner-Urdiales, Diego/0000-0001-9868-3396;
   Legaz Arrese, Alejandro/0000-0003-2644-9386; Munguia Izquierdo,
   Diego/0000-0001-7817-747X
FU "Catedra Real Madrid," European University of Madrid [P2016/19RM]
FX This work was partially supported by the "Catedra Real Madrid," European
   University of Madrid (project: P2016/19RM).
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NR 55
TC 57
Z9 58
U1 1
U2 29
PU AKADEMIAI KIADO ZRT
PI BUDAPEST
PA BUDAFOKI UT 187-189-A-3, H-1117 BUDAPEST, HUNGARY
SN 2062-5871
EI 2063-5303
J9 J BEHAV ADDICT
JI J. Behav. Addict.
PD MAR
PY 2017
VL 6
IS 1
BP 74
EP 83
DI 10.1556/2006.6.2017.018
PG 10
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA EQ6WC
UT WOS:000398223500009
PM 28358644
OA Green Published, gold, Green Accepted, Green Submitted
DA 2025-06-11
ER

PT J
AU McKinnon, CR
   Garvin, JT
AF McKinnon, Caroline R.
   Garvin, Jane T.
TI Weight Reduction Goal Achievement Among Veterans With Mental Health
   Diagnoses
SO JOURNAL OF THE AMERICAN PSYCHIATRIC NURSES ASSOCIATION
LA English
DT Article
DE mental illness; obesity; veterans; outcomes; prevalence
ID POSTTRAUMATIC-STRESS-DISORDER; AFGHANISTAN VETERANS; METABOLIC SYNDROME;
   UNITED-STATES; OBESITY; PREVALENCE; RISK; IRAQ; OVERWEIGHT; ILLNESS
AB BACKGROUND: Despite the use of weight management programs among veterans, the impact of mental health diagnoses on weight reduction goal achievement is unknown. AIMS: We aimed to describe the prevalence and association of mental health diagnoses with a 5% weight reduction goal achievement. METHODS: Logistic regression was used to describe the association between mental health diagnoses and weight reduction goal achievement at 6, 12, and 24 months among 402 veterans enrolled in a weight management program. RESULTS: More than 43% of veterans had a mental health diagnoses, with depressive disorders, posttraumatic stress disorder (PTSD), and substance use disorders being the most prevalent. At all three times, simply having a mental health diagnosis was not associated with weight reduction goal achievement. Specific diagnoses were associated with a greater likelihood of achieving weight reduction goals at 12 months (PTSD and Drug Use Disorder) and 24 months (Anxiety Disorder and Other Mental Health Diagnosis). CONCLUSION: The findings suggest that unhealthy weight is quite common for individuals with mental health diagnoses; however, weight reduction goal achievement may be equally likely for those with and without mental health diagnoses. The prevalence of mental health diagnoses among veterans seeking weight reduction suggests that psychiatric nurses should be aware of this common comorbidity.
C1 [McKinnon, Caroline R.] Augusta Univ, Coll Nursing, 987 St Sebastian Way,EC-4338, Augusta, GA 30912 USA.
   [Garvin, Jane T.] Univ St Augustine Hlth Sci, St Augustine, FL USA.
C3 University System of Georgia; Augusta University
RP McKinnon, CR (corresponding author), Augusta Univ, Coll Nursing, 987 St Sebastian Way,EC-4338, Augusta, GA 30912 USA.
EM cmckinnon@augusta.edu
RI McKinnon, Caroline/H-8126-2019
OI Garvin, Jane/0000-0001-6023-3269
FU Department of Veterans Affairs, Veterans Health Administration from
   Office of Academic Affairs; Department of Veterans Affairs, Veterans
   Health Administration from Charlie Norwood VAMC Office of Research and
   Development; Charlie Norwood VAMC Nursing Service Line in Augusta,
   Georgia; Department of Veterans Affairs, Veterans Health Administration
   from Charlie Norwood VAMC Research Service Line; Beta Omicron Chapter of
   Sigma Theta Tau, International; Augusta University College of Nursing
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: This
   article is based on work supported by the Department of Veterans
   Affairs, Veterans Health Administration to Dr. Garvin from: (1) Office
   of Academic Affairs, and the Charlie Norwood VAMC Office of Research and
   Development, with a full-time Postdoctoral Nursing Fellowship for Health
   Services Research in collaboration with Charlie Norwood VAMC Nursing
   Service Line in Augusta, Georgia and (2) Charlie Norwood VAMC Research
   Service Line with a Research Registered Nurse without compensation (WOC)
   appointment. Augusta University College of Nursing and Beta Omicron
   Chapter of Sigma Theta Tau, International provided additional funding to
   Dr. Garvin for support services.
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NR 32
TC 4
Z9 5
U1 0
U2 3
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1078-3903
EI 1532-5725
J9 J AM PSYCHIAT NURSES
JI J. Am. Psych. Nurses Assoc.
PD JUL
PY 2019
VL 25
IS 4
BP 257
EP 265
DI 10.1177/1078390318800594
PG 9
WC Nursing; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Psychiatry
GA IH1HG
UT WOS:000474241300004
PM 30239250
DA 2025-06-11
ER

PT J
AU Whitaker, KM
   Buman, MP
   Odegaard, AO
   Carpenter, KC
   Jacobs, DR
   Sidney, S
   Pereira, MA
AF Whitaker, Kara M.
   Buman, Matthew P.
   Odegaard, Andrew O.
   Carpenter, Katie C.
   Jacobs, David R., Jr.
   Sidney, Stephen
   Pereira, Mark A.
TI Sedentary Behaviors and Cardiometabolic Risk: An Isotemporal
   Substitution Analysis
SO AMERICAN JOURNAL OF EPIDEMIOLOGY
LA English
DT Article
DE cardiometabolic risk; Coronary Artery Risk Development in Young Adults;
   isotemporal substitution; sedentary behaviors
ID TELEVISION VIEWING TIME; PHYSICAL-ACTIVITY; ENERGY-EXPENDITURE;
   METABOLIC SYNDROME; CARDIOVASCULAR-DISEASE; SITTING TIME; YOUNG-ADULTS;
   OLDER-ADULTS; ASSOCIATIONS; DEPRESSION
AB Evidence suggests that time spent engaging in sedentary behaviors is associated with a greater risk of adverse cardiometabolic outcomes. We investigated the cross-sectional associations of 6 unique sedentary tasks (watching television, using the computer, completing paperwork, reading, talking on the telephone, and sitting in a car) with cardiometabolic risk factors, and also examined the effect of replacing one type of sedentary behavior with another on the level of cardiometabolic risk. Participants consisted of 3,211 individuals from the Coronary Artery Risk Development in Young Adults Study who visited the clinic between 2010 and 2011. Linear regression models examined the independent and joint associations of sedentary tasks with a composite cardiometabolic risk score, as well as with individual cardiometabolic risk factors (waist circumference, blood pressure, fasting glucose, insulin, triglycerides, and high density lipoprotein cholesterol) after adjusting for physical activity and other covariates. Replacing 2 hours of television viewing with 2 hours spent performing any other sedentary activity was associated with a lower cardiometabolic risk score of 0.06-0.09 standard deviations (all 95% confidence intervals: -0.13, -0.02). No other replacements of one type of sedentary task for another were significant. Study findings indicate that television viewing has a more adverse association with cardiometabolic risk factors than other sedentary behaviors.
C1 [Whitaker, Kara M.; Jacobs, David R., Jr.; Pereira, Mark A.] Univ Minnesota, Sch Publ Hlth, Div Epidemiol & Community Hlth, 1300 2nd St,Suite 300, Minneapolis, MN 55454 USA.
   [Buman, Matthew P.] Arizona State Univ, Coll Hlth Solut, Exercise Sci & Hlth Promot, Tempe, AZ USA.
   [Odegaard, Andrew O.] Univ Calif Irvine, Sch Med, Dept Epidemiol, Irvine, CA 92717 USA.
   [Carpenter, Katie C.] Native Amer Community Hlth Ctr Inc, Phoenix, AZ USA.
   [Sidney, Stephen] Kaiser Permanente Northern Calif, Div Res, Oakland, CA USA.
C3 University of Minnesota System; University of Minnesota Twin Cities;
   Arizona State University; Arizona State University-Tempe; University of
   California System; University of California Irvine; Kaiser Permanente
RP Whitaker, KM (corresponding author), Univ Minnesota, Sch Publ Hlth, Div Epidemiol & Community Hlth, 1300 2nd St,Suite 300, Minneapolis, MN 55454 USA.
EM whitaker@umn.edu
RI Whitaker, Kara/IXX-0778-2023; Jacobs, David/G-5405-2011; s,
   s/GYR-2278-2022; Buman, Matthew/AAJ-4447-2020
FU National Heart, Lung, and Blood Institute (NHLBI); Intramural Research
   Program of the National Institute on Aging (NIA); NHLBI
   [HHSN268201300025C, HHSN268201300026C, HHSN268201300027C,
   HHSN268201300028C, HHSN268201300029C, HHSN268200900041C, AG0005, R21
   HL121627-01, T32 HL007779]; NIA [HHSN268201300025C, HHSN268201300026C,
   HHSN268201300027C, HHSN268201300028C, HHSN268201300029C,
   HHSN268200900041C, AG0005, R21 HL121627-01, T32 HL007779]
FX This work was supported by National Heart, Lung, and Blood Institute
   (NHLBI), the Intramural Research Program of the National Institute on
   Aging (NIA), and an intra-agency agreement between the NHLBI and NIA
   (contracts HHSN268201300025C, HHSN268201300026C, HHSN268201300027C,
   HHSN268201300028C, HHSN268201300029C, HHSN268200900041C, intraagency
   agreement AG0005, and grants R21 HL121627-01 and T32 HL007779).
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NR 44
TC 21
Z9 21
U1 0
U2 17
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0002-9262
EI 1476-6256
J9 AM J EPIDEMIOL
JI Am. J. Epidemiol.
PD FEB
PY 2018
VL 187
IS 2
BP 181
EP 189
DI 10.1093/aje/kwx209
PG 9
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA FU4KD
UT WOS:000423821100001
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Teasdale, SB
   Samaras, K
   Wade, T
   Jarman, R
   Ward, PB
AF Teasdale, S. B.
   Samaras, K.
   Wade, T.
   Jarman, R.
   Ward, P. B.
TI A review of the nutritional challenges experienced by people living with
   severe mental illness: a role for dietitians in addressing physical
   health gaps
SO JOURNAL OF HUMAN NUTRITION AND DIETETICS
LA English
DT Review
DE diet; mental illness; nutrition; psychosis; schizophrenia
ID INDUCED WEIGHT-GAIN; RANDOMIZED CONTROLLED-TRIAL; RESTING
   ENERGY-EXPENDITURE; ANTIPSYCHOTIC MEDICATIONS; 2ND-GENERATION
   ANTIPSYCHOTICS; CARDIOVASCULAR-DISEASE; CARDIOMETABOLIC RISK; PSYCHOTIC
   DISORDERS; DIETARY IMPROVEMENT; METABOLIC SYNDROME
AB People experiencing a severe mental illness (SMI), such as schizophrenia, schizoaffective disorder, bipolar affective disorder or depression with psychotic features, have a 20-year mortality gap compared to the general population. This scandal of premature mortality' is primarily driven by preventable cardiometabolic disease, and recent research suggests that the mortality gap is widening. Multidisciplinary mental health teams often include psychiatrists, clinical psychologists, specialist mental health nurses, social workers and occupational therapists, offering a range of pharmacological and nonpharmacological treatments to enhance the recovery of clients who have experienced, or are experiencing a SMI. Until recently, lifestyle and life skills interventions targeting the poor physical health experienced by people living with SMI have not been offered in most routine clinical settings. Furthermore, there are calls to include dietary intervention as mainstream in psychiatry to enhance mental health recovery. With the integration of dietitians being a relatively new approach, it is important to review and assess the literature to inform practice. This review assesses the dietary challenges experienced by people with a SMI and discusses potential strategies for improving mental and physical health.
C1 [Teasdale, S. B.; Wade, T.; Jarman, R.] South Eastern Sydney Local Hlth Dist, Keeping Body Mind Program, Sydney, NSW, Australia.
   [Teasdale, S. B.; Ward, P. B.] Univ New South Wales, Sch Psychiat, Kensington, NSW, Australia.
   [Samaras, K.] St Vincents Hosp, Dept Endocrinol, Darlinghurst, NSW, Australia.
   [Samaras, K.] Garvan Inst Med Res, Diabet & Metab Div, Darlinghurst, NSW, Australia.
   [Ward, P. B.] South Eastern Sydney Local Hlth Dist, Schizophrenia Res Unit, Liverpool, Australia.
   [Ward, P. B.] Ingham Inst Appl Med Res, Liverpool, Australia.
C3 South Eastern Sydney Local Health District; University of New South
   Wales Sydney; NSW Health; St Vincents Hospital Sydney; Garvan Institute
   of Medical Research; Ingham Institute for Applied Medical Research
RP Teasdale, SB (corresponding author), South Eastern Sydney Local Hlth Dist, Keeping Body Mind Program, 26 Llandaff St, Bondi Jct, NSW 2022, Australia.
EM scott.teasdale@health.nsw.gov.au
RI Teasdale, Scott/AFP-0676-2022; Ward, Philip/JCE-6293-2023
OI Ward, Philip/0000-0002-5779-7722; Teasdale, Scott/0000-0001-6769-8421
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NR 81
TC 48
Z9 51
U1 0
U2 38
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0952-3871
EI 1365-277X
J9 J HUM NUTR DIET
JI J. Hum. Nutr. Diet.
PD OCT
PY 2017
VL 30
IS 5
BP 545
EP 553
DI 10.1111/jhn.12473
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nutrition & Dietetics
GA FH3QJ
UT WOS:000411064100001
PM 28419586
DA 2025-06-11
ER

PT J
AU Zeugmann, S
   Quante, A
   Popova-Zeugmann, L
   Kössler, W
   Heuser, I
   Anghelescu, I
AF Zeugmann, Sara
   Quante, Arnim
   Popova-Zeugmann, Louchka
   Koessler, Wolfgang
   Heuser, Isabella
   Anghelescu, Ion
TI PATHWAYS LINKING EARLY LIFE STRESS, METABOLIC SYNDROME, AND THE
   INFLAMMATORY MARKER FIBRINOGEN IN DEPRESSED INPATIENTS
SO PSYCHIATRIA DANUBINA
LA English
DT Article
DE early life stress; metabolic syndrome; inflammatory; fibrinogen;
   depression
ID MAJOR DEPRESSION; CHILDHOOD MALTREATMENT; CARDIOVASCULAR-DISEASE;
   FOLLOW-UP; SYMPTOMS; EVENTS; RISK; ASSOCIATION; EXPERIENCES; BIOMARKERS
AB Background: Previous research has shown that metabolic syndrome as well as early life stress can account for immunoactivation (e.g. in the form of altered fibrinogen levels) in patients with major depression. This study aims at assessing the relationship between components of metabolic syndrome, early life stress and fibrinogen levels, taking the severity of depression into consideration.
   Subjects and methods: Measures of early life stress and signs of metabolic syndrome were collected in 58 adult inpatients diagnosed with depression. The relationships between the factors were assessed by means of path analyses. Two main models were tested: the first model with metabolic syndrome mediating between early life stress and fibrinogen levels and the second model without the mediating effect of metabolic syndrome.
   Results: The first model was not supported by our data (chi(2)=7.02, df=1, p=0.008, CFI=0.00, NNFI=-9.44, RMSEA=0.50). The second model however provided an excellent fit for the data (chi(2)=0.02, df=1, p=0.90, CFI=1.00, NNFI=2.71, RMSEA=0.00). Extending the models by introducing severity of depression into them did not yield good indices of fit.
   Conclusions: The developmental trajectory between early life stress and inflammation appears not to be mediated by metabolic syndrome associated factors in our sample. Possible reasons including severity and type of early life stress, as well as potential epigenetic influences are discussed.
C1 [Zeugmann, Sara; Quante, Arnim; Heuser, Isabella; Anghelescu, Ion] Univ Med Berlin, Dept Psychiat & Psychotherapy, Charite, Berlin, Germany.
   [Popova-Zeugmann, Louchka; Koessler, Wolfgang] Humboldt Univ, Dept Comp Sci, D-10099 Berlin, Germany.
C3 Berlin Institute of Health; Free University of Berlin; Humboldt
   University of Berlin; Charite Universitatsmedizin Berlin; Humboldt
   University of Berlin
RP Zeugmann, S (corresponding author), Univ Med Berlin, Dept Psychiat & Psychotherapy, Charite, Campus Benjamin Franklin, Berlin, Germany.
EM sara.zeugmann@charite.de
RI Koessler, Wolfgang/AAC-6503-2020
OI Heuser, Isabella/0000-0001-7075-1158
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NR 64
TC 10
Z9 12
U1 0
U2 5
PU MEDICINSKA NAKLADA
PI ZAGREB
PA VLASKA 69, HR-10000 ZAGREB, CROATIA
SN 0353-5053
J9 PSYCHIAT DANUB
JI Psychiatr. Danub.
PD MAR
PY 2012
VL 24
IS 1
BP 57
EP 65
PG 9
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 919MA
UT WOS:000302330600007
PM 22447087
DA 2025-06-11
ER

PT J
AU Young, AH
   Grunze, H
AF Young, A. H.
   Grunze, H.
TI Physical health of patients with bipolar disorder
SO ACTA PSYCHIATRICA SCANDINAVICA
LA English
DT Article
DE bipolar disorder; depression; diabetes; metabolic syndrome; obesity
ID MENTAL-ILLNESS; MOOD DISORDERS; PREVALENCE; OPPORTUNITIES; PERSPECTIVES;
   INDIVIDUALS; COMORBIDITY; EPISODE; SMOKING; PEOPLE
AB Objective This article reviews the characteristics of bipolar disorder and approaches to minimise physical health risks, as well as treatment options, and their influence on patient quality of life (QoL). Method The content of this article is based on the proceedings of a 1-day standalone symposium in November 2011 exploring how to establish a bipolar clinic within the context of existing services in the UK's National Health Service. Results Bipolar disorder is a common mental disorder and often under-recognised in patients with major depressive episodes. Patients are largely dependent on family and carers to lead normal lifestyles and have difficulties maintaining relationships. Mental health and physical health are closely linked, with risk factors such as weight gain, metabolic syndrome, smoking and diabetes contributing to cardiovascular disease and early death. Antipsychotics may induce treatment-related comorbidities, thus further contributing to a low QoL of patients. Symptoms of comorbidity or depression are frequently relieved through self-medication and substance abuse, thus increasing patient health and suicide risk. Therefore, regular health monitoring and patient education in risk factor minimisation are required. Conclusion Early pharmacotherapeutic and psychoeducational interventions are required to improve treatment outcomes, as well as improving patient understanding of ways to minimise comorbidity development.
C1 [Young, A. H.] Univ London Imperial Coll Sci Technol & Med, WLMHT, London, England.
   [Grunze, H.] Newcastle Univ, Acad Psychiat & Reg Affect Disorders Serv, Newcastle Upon Tyne NE4 5PL, Tyne & Wear, England.
C3 Imperial College London; Newcastle University - UK
RP Grunze, H (corresponding author), Newcastle Univ, Acad Psychiat & Reg Affect Disorders Serv, Wolfson Res Ctr, Inst Neurosci, Campus Ageing & Vital,Westgate Rd, Newcastle Upon Tyne NE4 5PL, Tyne & Wear, England.
EM heinz.grunze@newcastle.ac.uk
RI Grunze, Heinz/J-1198-2019
OI Young, Allan/0000-0003-2291-6952; Grunze, Heinz/0000-0003-4712-8979
FU Bristol-Myers Squibb, Uxbridge, UK; Ogilvy Healthworld Medical
   Education, London, UK; Bristol-Myers Squibb; NIMH (USA); CIHR (Canada);
   NARSAD (USA); Stanley Medical Research Institute (USA); MRC (UK);
   Wellcome Trust (UK); Royal College of Physicians (Edinburgh); BMA (UK);
   UBC-VGH Foundation (Canada); WEDC (Canada); CCS Depression Research Fund
   (Canada); MSFHR (Canada); DFG (Germany); Pfizer Inc (USA); AstraZeneca
   (Germany); Novartis (Germany); AstraZeneca; BMS; Cephalon; Eli Lilly;
   Gedeon Richter; Janssen-Cilag; Lundbeck; Merck; Organon; Pfizer Inc;
   Sanofi-Aventis; Sepracor; Servier; UBC
FX The meeting on which this supplement is based was supported by
   Bristol-Myers Squibb, Uxbridge, UK. Editorial support for the
   preparation of this manuscript was provided by Ogilvy Healthworld
   Medical Education, London, UK; funding was provided by Bristol-Myers
   Squibb.Professor Allan H. Young is employed by Imperial College London.
   He is an Honorary Consultant Psychiatrist with WLMHT (NHS UK); has given
   paid lectures and advisory boards for all major pharmaceutical companies
   with drugs used in affective and related disorders; has no share
   holdings in pharmaceutical companies; was a Lead Investigator for the
   Embolden Study (AstraZeneca), BCI Neuroplasticity study and Aripiprazole
   Mania Study, and for investigator-initiated studies from AstraZeneca,
   Eli Lilly and Wyeth. He has received grant funding (past and present)
   from NIMH (USA); CIHR (Canada); NARSAD (USA); Stanley Medical Research
   Institute (USA); MRC (UK); Wellcome Trust (UK); Royal College of
   Physicians (Edinburgh); BMA (UK); UBC-VGH Foundation (Canada); WEDC
   (Canada); CCS Depression Research Fund (Canada); and MSFHR (Canada) and
   is coholder of one European patent for the use of glucocorticoid
   antagonists in the treatment for depression.Professor Heinz Grunze is
   employed by Newcastle University. He is an Honorary Consultant
   Psychiatrist with NTW (NHS UK). He received grant funding (past and
   present) from Stanley Medical Research Institute (USA); MRC (UK), DFG
   (Germany), Pfizer Inc (USA), AstraZeneca (Germany) and Novartis
   (Germany). He received consulting fees and honoraria within the last 3
   years from AstraZeneca, BMS, Cephalon, Eli Lilly, Gedeon Richter,
   Janssen-Cilag, Lundbeck, Merck, Organon, Pfizer Inc, Sanofi-Aventis,
   Sepracor, Servier and UBC. Neither him nor any members of his family
   have shares in any pharmaceutical company or could benefit financially
   from increases or decreases in sales of any psychotropic medication.
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NR 34
TC 46
Z9 47
U1 1
U2 30
PU WILEY-BLACKWELL
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0001-690X
J9 ACTA PSYCHIAT SCAND
JI Acta Psychiatr. Scand.
PD MAY
PY 2013
VL 127
SU 442
SI SI
BP 3
EP 10
DI 10.1111/acps.12117
PG 8
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 127VV
UT WOS:000317727800002
PM 23581787
DA 2025-06-11
ER

PT J
AU Lin, YH
   Chang, HT
   Tseng, YH
   Chen, HS
   Chiang, SC
   Chen, TJ
   Hwang, SJ
AF Lin, Yi-Hsuan
   Chang, Hsiao-Ting
   Tseng, Yen-Han
   Chen, Harn-Shen
   Chiang, Shu-Chiung
   Chen, Tzeng-Ji
   Hwang, Shinn-Jang
TI Changes in metabolic syndrome affect the health-related quality of life
   of community-dwelling adults
SO SCIENTIFIC REPORTS
LA English
DT Article
ID INSULIN-RESISTANCE SYNDROME; SELF-RATED HEALTH; ASSOCIATION; OBESITY;
   DEPRESSION; PREVALENCE
AB Metabolic syndrome (MetS) is associated with cardiovascular diseases, type 2 diabetes, chronic renal diseases, and all-cause mortality. Furthermore, MetS is associated with poor health-related quality of life (HRQOL). However, the impact of dynamic changes in MetS on changes in the HRQOL was not previously explored. This was an eight-year, prospective cohort study in which 906 middle-aged adults from Shipai, Taipei in northern Taiwan were enrolled during 2009-2010 (baseline). Of those sampled, 427 participants completed the follow-up investigation after 8 years. The HRQOL was measured using the Short Form Health Survey (SF-36). Other variables including age, sex, marital status, level of education, smoking, alcohol consumption, baseline body mass index, and changes in physical activity were adjusted. Compared with adults who never experienced MetS, adults with persistent MetS had a negative change in mental HRQOL (beta - 4.20, 95% CI - 7.54 to - 0.86, p = 0.01). The negative changes of persistent MetS on the HRQOL were in the domains of vitality and mental health (beta - 4.42, 95% CI - 8.10 to - 0.73 and beta - 3.47, 95% CI - 6.90 to - 0.04, respectively). Women and overweight adults were vulnerable to the detrimental effects of persistent MetS. For better HRQOL, more resources should be devoted to reversing MetS in public health.
C1 [Lin, Yi-Hsuan] Cheng Hsin Gen Hosp, Dept Family Med, Taipei, Taiwan.
   [Lin, Yi-Hsuan; Chang, Hsiao-Ting; Tseng, Yen-Han; Chen, Harn-Shen; Chen, Tzeng-Ji; Hwang, Shinn-Jang] Natl Yang Ming Chiao Tung Univ, Fac Med, Sch Med, Taipei, Taiwan.
   [Chang, Hsiao-Ting; Chen, Tzeng-Ji; Hwang, Shinn-Jang] Taipei Vet Gen Hosp, Dept Family Med, Taipei, Taiwan.
   [Tseng, Yen-Han] Taipei Vet Gen Hosp, Dept Chest Med, Taipei, Taiwan.
   [Chen, Harn-Shen] Taipei Vet Gen Hosp, Dept Med, Div Endocrinol & Metab, Taipei, Taiwan.
   [Chiang, Shu-Chiung; Chen, Tzeng-Ji] Natl Yang Ming Chiao Tung Univ, Inst Hosp & Hlth Care Adm, Sch Med, Taipei, Taiwan.
C3 Cheng Hsin General Hospital; National Yang Ming Chiao Tung University;
   Taipei Veterans General Hospital; Taipei Veterans General Hospital;
   Taipei Veterans General Hospital; National Yang Ming Chiao Tung
   University
RP Chang, HT (corresponding author), Natl Yang Ming Chiao Tung Univ, Fac Med, Sch Med, Taipei, Taiwan.; Chang, HT (corresponding author), Taipei Vet Gen Hosp, Dept Family Med, Taipei, Taiwan.
EM htchang.tw@gmail.com
RI Chiang, Shu-Chiung/GPX-6643-2022; Chen, TJ/AAH-8430-2021
FU Taipei Veterans General Hospital, Taipei, Taiwan [V96S3-001, V97S3-001,
   V98S3-001, V99S3-001, 106-E-005-2]
FX The authors would like to thank all participants in this study. This
   work was supported by the Taipei Veterans General Hospital, Taipei,
   Taiwan (Grant number: V96S3-001, -002, -005; V97S3-001, -002, -005;
   V98S3-001, -002, -005; V99S3-001, -002, -005; 106-E-005-2).
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NR 44
TC 17
Z9 18
U1 0
U2 5
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD OCT 12
PY 2021
VL 11
IS 1
AR 20267
DI 10.1038/s41598-021-99767-y
PG 9
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Science & Technology - Other Topics
GA WG2MF
UT WOS:000706830500011
PM 34642379
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Lazarev, A
   Nath, S
   Nguyen, CQ
   Demian, AM
   Bertasi, RAO
   Bertasi, TGO
   Pujalte, GGA
AF Lazarev, Artemii
   Nath, Sahil
   Nguyen, Christine Q.
   Demian, Anna M.
   Bertasi, Raphael A. O.
   Bertasi, Tais G. O.
   Pujalte, George G. A.
TI Sports and Weight Control in Children
SO CUREUS JOURNAL OF MEDICAL SCIENCE
LA English
DT Review
DE physical activity; weight control; adolescent; sports; pediatric obesity
ID FATTY LIVER-DISEASE; CHILDHOOD OBESITY; CARDIOMETABOLIC RISK; METABOLIC
   SYNDROME; OVERWEIGHT; ADOLESCENTS; DEPRESSION; PREVALENCE; ADIPOSITY; US
AB Pediatric obesity is a global concern with distressing comorbid conditions, including mood disturbance, cardiovascular changes, endocrine imbalance, liver disease, sleep apnea, and orthopedic conditions. The primary treatment of this condition includes physical activity. Participating in organized sports has been shown to reduce weight and the complications of pediatric obesity more effectively than individual exercise.
C1 [Lazarev, Artemii] Mt Sinai Hosp Chicago, Internal Med, Chicago, IL USA.
   [Nath, Sahil; Nguyen, Christine Q.; Demian, Anna M.; Pujalte, George G. A.] Mayo Clin, Family Med, Jacksonville, FL USA.
   [Bertasi, Raphael A. O.; Bertasi, Tais G. O.] Mt Sinai Morningside West, Internal Med, New York, NY 10025 USA.
C3 Mayo Clinic
RP Bertasi, RAO (corresponding author), Mt Sinai Morningside West, Internal Med, New York, NY 10025 USA.
EM r.bertasi@icloud.com
RI Lazarev, Artemii/MIO-3580-2025; Pujalte, George/AAR-3996-2020; Bertasi,
   Raphael/GYR-1814-2022
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NR 61
TC 1
Z9 1
U1 2
U2 8
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
EI 2168-8184
J9 CUREUS J MED SCIENCE
JI Cureus J Med Sci
PD FEB 6
PY 2024
VL 16
IS 2
AR e53731
DI 10.7759/cureus.53731
PG 6
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA IT6R9
UT WOS:001168631500012
PM 38455821
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Zhang, PX
   Zhang, X
   Gao, B
   Gao, YX
   Pan, Y
AF Zhang, Pingxi
   Zhang, Xin
   Gao, Bo
   Gao, Yixuan
   Pan, Yun
TI The impact of metabolic syndrome on the cerebral cortex: a Mendelian
   randomization study
SO CEREBRAL CORTEX
LA English
DT Article
DE metabolic syndrome; cerebral cortex; Mendelian randomization (MR);
   Alzheimer's disease (AD); major depression (MD)
ID TEMPORAL CORTEX; BRAIN; ASSOCIATION; INFLAMMATION; EDUCATION; GLUCOSE;
   SYSTEM
AB Metabolic syndrome exhibits associations with diverse neurological disorders, and its potential influence on the cerebral cortex may be one of the many potential factors contributing to these adverse outcomes. In this study, we aimed to investigate the causal relationship between metabolic syndrome and changes in cerebral cortex structure using Mendelian randomization analysis. Genome-wide association study data for the 5 components of metabolic syndrome were obtained from individuals of European descent in the UK Biobank. Genome-wide association study data for 34 known cortical functional regions were sourced from the ENIGMA Consortium. Data on Alzheimer's disease, major depression, and anxiety disorder were obtained from the IEU Open genome-wide association study database. The causal links between metabolic syndrome elements and cerebral cortex architecture were evaluated using inverse variance weighting, Mendelian randomization-Egger, and weighted median techniques, with inverse variance weighting as the primary method. Inverse variance weighting, Mendelian randomization Egger, weighted median, simple mode, and weighted mode methods were employed to assess the relationships between metabolic syndrome and neurological diseases (Alzheimer's disease, major depression, and anxiety disorder). Outliers, heterogeneity, and pleiotropy were assessed using Cochran's Q test, MR-PRESSO, leave-one-out analysis, and funnel plots. Globally, no causal link was found between metabolic syndrome and overall cortical thickness or surface area. However, regionally, metabolic syndrome may influence the surface area of specific regions, including the caudal anterior cingulate, postcentral, posterior cingulate, rostral anterior cingulate, isthmus cingulate, superior parietal, rostral middle frontal, middle temporal, insula, pars opercularis, cuneus, and inferior temporal. It may also affect the thickness of the medial orbitofrontal, caudal middle frontal, paracentral, superior frontal, superior parietal, and supramarginal regions. These findings were nominally significant and withstood sensitivity analyses, showing no substantial heterogeneity or pleiotropy. Furthermore, we found an association between metabolic syndrome and the risk of Alzheimer's disease, major depression, and anxiety disorder. This study suggests a potential association between metabolic syndrome and changes in cerebral cortex structure, which may underlie certain neurological disorders. Furthermore, we found an association between metabolic syndrome and the risk of Alzheimer's disease, major depression, and anxiety disorder. Early diagnosis of metabolic syndrome holds significance in preventing these neurological disorders.
C1 [Zhang, Pingxi; Zhang, Xin; Gao, Yixuan] Dali Univ, Coll Basic Med Sci, 22 Wanhua Rd, Dali 671000, Yunnan, Peoples R China.
   [Gao, Bo; Pan, Yun] Dali Univ, Affiliated Hosp 1, Dept Pathol, 32 Jiashibo Rd, Dali 671000, Yunnan, Peoples R China.
C3 Dali University; Dali University
RP Pan, Y (corresponding author), Dali Univ, Affiliated Hosp 1, Dept Pathol, 32 Jiashibo Rd, Dali 671000, Yunnan, Peoples R China.
EM zpxi@foxmail.com; 1762669261@qq.com; gaobo229@163.com;
   doctortrees@qq.com; panyun09@163.com
RI Gao, Yixuan/JXM-0025-2024; gao, bo/MFI-9383-2025; Zhang,
   Xin/MIP-9077-2025
FU National Natural Science Foundation of China [82160044, 81960042];
   National Natural Science Foundation of China [82160044]
FX The author(s) declare financial support was received for the research,
   authorship, and/or publication of this article. This research was funded
   by The National Natural Science Foundation of China (Grant numbers
   82160044 and 81960042). The APC was funded by The National Natural
   Science Foundation of China (Grant number 82160044).
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NR 67
TC 0
Z9 0
U1 0
U2 1
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1047-3211
EI 1460-2199
J9 CEREB CORTEX
JI Cereb. Cortex
PD AUG 27
PY 2024
VL 34
IS 8
AR bhae342
DI 10.1093/cercor/bhae342
PG 11
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA D9S9X
UT WOS:001299518700002
PM 39191665
OA hybrid
DA 2025-06-11
ER

PT J
AU Doom, JR
   Deer, LK
   Dabelea, D
   LeBourgeois, MK
   Lumeng, JC
   Martin, CK
   Hankin, BL
   Davis, EP
AF Doom, Jenalee R.
   Deer, LillyBelle K.
   Dabelea, Dana
   LeBourgeois, Monique K.
   Lumeng, Julie C.
   Martin, Corby K.
   Hankin, Benjamin L.
   Davis, Elysia Poggi
TI Biological and Behavioral Pathways From Prenatal Depression to Offspring
   Cardiometabolic Risk: Testing the Developmental Origins of Health and
   Disease Hypothesis
SO DEVELOPMENTAL PSYCHOLOGY
LA English
DT Article
DE prenatal depression; developmental origins of health and disease;
   cardiometabolic risk; intergenerational transmission; prenatal
   development
ID CORTICOTROPIN-RELEASING HORMONE; MATERNAL DEPRESSION; CARDIOVASCULAR
   RISK; PHYSICAL-ACTIVITY; ANTENATAL DEPRESSION; PRETERM BIRTH; IN-UTERO;
   PERINATAL DEPRESSION; SOCIAL DETERMINANTS; INSULIN-SECRETION
AB Given prior literature focused on the Developmental Origins of Health and Disease framework, there is strong rationale to hypothesize that reducing depression in the prenatal period will cause improvements in offspring cardiometabolic health. The current review outlines evidence that prenatal depression is associated with offspring cardiometabolic risk and health behaviors. We review evidence of these associations in humans and in nonhuman animals at multiple developmental periods, from the prenatal period (maternal preeclampsia, gestational diabetes), neonatal period (preterm birth, small size at birth), infancy (rapid weight gain), childhood and adolescence (high blood pressure, impaired glucose-insulin homeostasis, unfavorable lipid profiles, abdominal obesity), and into adulthood (diabetes, cardiovascular disease). In addition to these cardiometabolic outcomes, we focus on health behaviors associated with cardiometabolic risk, such as child eating behaviors, diet, physical activity, and sleep health. Our review focuses on child behaviors (e.g., emotional eating, preference for highly palatable foods, short sleep duration) and parenting behaviors (e.g., pressuring child to eat, modeling of health behaviors). These changes in health behaviors may be detected before changes to cardiometabolic outcomes, which may allow for early identification of and prevention for children at risk for poor adult cardiometabolic outcomes. We also discuss the methods of the ongoing Care Project, which is a randomized clinical trial to test whether reducing prenatal maternal depression improves offspring's cardiometabolic health and health behaviors in preschool. The goal of this review and the Care Project are to inform future research, interventions, and policies that support prenatal mental health and offspring cardiometabolic health.
C1 [Doom, Jenalee R.; Deer, LillyBelle K.; Davis, Elysia Poggi] Univ Denver, Dept Psychol, 2155 South Race St, Denver, CO 80210 USA.
   [Dabelea, Dana] Colorado Sch Publ Hlth, Dept Epidemiol, Aurora, CO USA.
   [Dabelea, Dana] Univ Colorado, Lifecourse Epidemiol Adipos & Diabet LEAD Ctr, Anschutz Med Campus, Aurora, CO USA.
   [Dabelea, Dana] Univ Colorado, Sch Med, Dept Pediat, Anschutz Med Campus, Aurora, CO USA.
   [LeBourgeois, Monique K.] Univ Colorado Boulder, Dept Integrat Physiol, Boulder, CO USA.
   [Lumeng, Julie C.] Univ Michigan, Sch Publ Hlth, Dept Nutr Sci, Ann Arbor, MI USA.
   [Lumeng, Julie C.] Univ Michigan, Med Sch, Dept Pediat, Ann Arbor, MI USA.
   [Martin, Corby K.] Louisiana State Univ, Pennington Biomed Res Ctr, Baton Rouge, LA USA.
   [Hankin, Benjamin L.] Univ Illinois, Dept Psychol, Champaign, IL USA.
   [Davis, Elysia Poggi] Univ Calif Irvine, Dept Pediat, Irvine, CA USA.
C3 University of Denver; Colorado School of Public Health; University of
   Colorado System; University of Colorado Anschutz Medical Campus;
   University of Colorado System; University of Colorado Anschutz Medical
   Campus; University of Colorado System; University of Colorado Boulder;
   University of Michigan System; University of Michigan; University of
   Michigan System; University of Michigan; Louisiana State University
   System; Louisiana State University; Pennington Biomedical Research
   Center; University of Illinois System; University of Illinois
   Urbana-Champaign; University of California System; University of
   California Irvine
RP Doom, JR (corresponding author), Univ Denver, Dept Psychol, 2155 South Race St, Denver, CO 80210 USA.
EM Jena.Doom@du.edu
RI Davis, Elysia/B-7621-2013; Deer, LillyBelle/W-9369-2019
OI Doom, Jenalee/0000-0003-2857-0817
FU Nutrition Obesity Research Center - National Institute of Diabetes and
   Digestive and Kidney Diseases [P30 DK072476]; Louisiana Clinical and
   Translational Science Center - National Institute of General Medical
   Sciences [U54 GM104940];  [R01HL155744];  [R01MH109662];  [K01HL143159];
    [F32HL165844]
FX The authors would like to thank their funding sources (R01HL155744 to
   Jenalee R. Doom, Benjamin L. Hankin, and Elysia Poggi Davis;R01MH109662
   to Benjamin L. Hank in and Elysia Poggi Davis;K01HL143159 to Jenalee R.
   Doom; and F32HL165844 to Lilly BelleK. Deer) and the participants in the
   ongoing Care Project. Corby K. Martin's institution is supported by two
   center grants: (a) the Nutrition Obesity Research Center (Grant P30
   DK072476), sponsored by the National Institute of Diabetes and Digestive
   and Kidney Diseases, and (b) the Louisiana Clinical and Translational
   Science Center (Grant U54 GM104940), which is funded by the National
   Institute of General Medical Sciences.
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NR 219
TC 3
Z9 3
U1 3
U2 9
PU AMER PSYCHOLOGICAL ASSOC
PI WASHINGTON
PA 750 FIRST ST NE, WASHINGTON, DC 20002-4242 USA
SN 0012-1649
EI 1939-0599
J9 DEV PSYCHOL
JI Dev. Psychol.
PD SEP
PY 2024
VL 60
IS 9
SI SI
BP 1620
EP 1638
DI 10.1037/dev0001704
EA FEB 2024
PG 19
WC Psychology, Developmental
WE Social Science Citation Index (SSCI)
SC Psychology
GA H6Q4N
UT WOS:001162470800001
PM 38358670
OA hybrid
DA 2025-06-11
ER

PT J
AU Smith, ML
   Gelaye, B
   Tsai, AC
   Gradus, JL
AF Smith, Meghan L.
   Gelaye, Bizu
   Tsai, Alexander C.
   Gradus, Jaimie L.
TI Mediation of the association between depression and coronary heart
   disease by metabolic syndrome components
SO ANNALS OF EPIDEMIOLOGY
LA English
DT Article
DE Depression; Cardiovascular disease; Causal mediation; Coronary heart
   disease; Mental health; Metabolic syndrome
ID MIDDLE-AGED MEN; CARDIOVASCULAR-DISEASE; ABDOMINAL OBESITY; MAJOR
   DEPRESSION; BLOOD-PRESSURE; SYMPTOMS; ANXIETY; RISK; METAANALYSIS;
   DEFINITION
AB Background: Depression is associated with incident coronary heart disease (CHD) via a pathway that may be causal, but the mechanisms underlying this association are unclear. We assessed the extent to which metabolic syndrome (MetS) and its components (i.e., elevated waist circumference, low high-density lipoprotein [HDL] cholesterol, elevated triglycerides, elevated blood pressure, and elevated fasting plasma glucose) may mediate this association. Methods: Data were Framingham Heart Study Research Materials obtained from the National Heart, Lung, and Blood Institute (NHLBI) Biologic Specimen and Data Repository Information Coordinating Center. We used Cox proportional hazards regression to estimate adjusted hazard ratios (aHR) representing the total effect (aHRTE) of probable depression, measured via the Centers for Epidemiological Studies - Depression scale, on incident CHD over approximately 18 years. Using inverse odds ratio weighting, we decomposed this estimate into natural direct effects (aHRNDE) and natural indirect effects (aHRNIE) through potential mediators (measured approximately three years after depression). Results: Probable depression was associated with incident CHD (aHRTE=1.45, 95% confidence interval [CI]: 0.93, 2.25), and elevated waist circumference partially mediated this association (aHRNDE=1.34, 95% CI: 0.76-2.32; aHRNIE=1.08, 95% CI: 0.63-1.91). We did not find evidence of additional mediation by additional MetS components. Conclusions: Elevated waist circumference appears to play a role in the association between depression and CHD.
C1 [Smith, Meghan L.; Gradus, Jaimie L.] Boston Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02215 USA.
   [Gelaye, Bizu] Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA.
   [Gelaye, Bizu; Tsai, Alexander C.] Harvard Univ, Boston, MA USA.
   [Tsai, Alexander C.] Massachusetts Gen Hosp, Ctr Global Hlth, Boston, MA USA.
   [Tsai, Alexander C.] Mongan Inst, Boston, MA USA.
   [Gradus, Jaimie L.] Boston Univ, Dept Psychiat, Sch Med, Boston, MA USA.
C3 Boston University; Harvard University; Harvard T.H. Chan School of
   Public Health; Harvard University; Harvard University; Harvard
   University Medical Affiliates; Massachusetts General Hospital; Boston
   University
RP Smith, ML (corresponding author), Boston Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02215 USA.
EM mlsmith1@bu.edu
RI Gelaye, Bizu/GSI-6520-2022; Tsai, Alexander/F-4247-2015
OI Smith, Meghan/0000-0003-0444-2845
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NR 71
TC 0
Z9 0
U1 2
U2 6
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1047-2797
EI 1873-2585
J9 ANN EPIDEMIOL
JI Ann. Epidemiol.
PD APR
PY 2024
VL 92
BP 1
EP 7
DI 10.1016/j.annepidem.2024.02.003
EA FEB 2024
PG 7
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA MZ9S4
UT WOS:001197580300001
PM 38341050
DA 2025-06-11
ER

PT J
AU Joshi, S
   Maheshwari, RA
AF Joshi, Snehal
   Maheshwari, Rajesh A.
TI Unveiling the Power of Vitamin D: Key Insights into its Role in Health
SO JOURNAL OF YOUNG PHARMACISTS
LA English
DT Review
DE Vitamin D; Metabolic syndrome; Cancer; Autoimmune diseases;
   Inflammation; Mental health disorders
ID D-RECEPTOR; METABOLIC SYNDROME; D DEFICIENCY; CALCIUM SUPPLEMENTATION;
   INSULIN-RESISTANCE; CANCER; RISK; PREVENTION; ASSOCIATION; METAANALYSIS
AB Vitamin D, often called the "sunshine vitamin," is essential for various physiological processes and overall health, produced in the skin through UVB exposure and obtainable from food and supplements. It regulates calcium and phosphorus, supports bone health, and prevents conditions like osteoporosis and rickets. Beyond skeletal benefits, evidence links vitamin D deficiency to chronic health issues such as metabolic syndrome, cancer, autoimmune diseases, inflammation, and mental health disorders. Research indicates that vitamin D could lessen the risk of these conditions by modulating immune function, reducing inflammation, and promoting cellular growth, while supplementation has shown promise in improving mood and alleviating depression and anxiety, particularly in deficient individuals. Additionally, vitamin D contributes to skin health, with potential benefits in treating psoriasis and preventing skin cancer. Its anti-inflammatory properties further suggest it may lower the risk of chronic diseases like cardiovascular and autoimmune disorders. Given its broad effects on health, maintaining adequate vitamin D levels is crucial for disease prevention and overall well-being, and additional research is required to gain a complete understanding of therapeutic potential in managing chronic conditions.
C1 [Joshi, Snehal; Maheshwari, Rajesh A.] Sumandeep Vidyapeeth Univ, Dept Pharm, Vadodara 391760, Gujarat, India.
C3 Sumandeep Vidyapeeth
RP Maheshwari, RA (corresponding author), Sumandeep Vidyapeeth Univ, Dept Pharm, Vadodara 391760, Gujarat, India.
EM rajpharma2007@gmail.com
RI Maheshwari, Rajesh/AAV-5600-2020
FU Department of Pharmacy, Sumandeep Vidyapeeth
FX The authors would like to express their sincere gratitude to the
   Department of Pharmacy, Sumandeep Vidyapeeth (Deemed to be University) ,
   for their continuous support and encouragement during the preparation of
   this review article.
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NR 53
TC 0
Z9 0
U1 0
U2 0
PU INPHARM ASSOC, PHCOG NET
PI BANGELORE
PA 17, II FLOOR, BUDDHA VIHAR RD, COX TOWN, BANGELORE, 560 005, INDIA
SN 0975-1483
EI 0975-1505
J9 J YOUNG PHARM
JI J. Young Pharm.
PD APR-JUN
PY 2025
VL 17
IS 2
BP 264
EP 270
DI 10.5530/jyp.20251662
PG 7
WC Pharmacology & Pharmacy
WE Emerging Sources Citation Index (ESCI)
SC Pharmacology & Pharmacy
GA 2ZE1J
UT WOS:001494797100004
DA 2025-06-11
ER

PT J
AU Vogelzangs, N
   Beekman, ATF
   Dik, MG
   Bremmer, MA
   Comijs, HC
   Hoogendijk, WJG
   Deeg, DJH
   Penninx, BWJH
AF Vogelzangs, Nicole
   Beekman, Aartjan T. F.
   Dik, Miranda G.
   Bremmer, Marijke A.
   Comijs, Hannie C.
   Hoogendijk, Witte J. G.
   Deeg, Dorly J. H.
   Penninx, Brenda W. J. H.
TI Late-Life Depression, Cortisol, and the Metabolic Syndrome
SO AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
LA English
DT Article
DE Depression; metabolic syndrome; cortisol
ID HYPERCORTISOLEMIC DEPRESSION; YOUNG-ADULTS; SYMPTOMS; HEALTH; ANXIETY
AB Objectives: High-cortisol levels in depressed persons could possibly give rise to the metabolic syndrome. This study investigated cross-sectionally whether depression and high-cortisol levels increased the odds of metabolic syndrome in an older community-based sample. Methods: In 1,212 participants, aged >= 65 years, enrolled in the Longitudinal Aging Study Amsterdam, depression (major [1-month diagnosis] or subthreshold [no 1-month diagnosis, but symptoms]), metabolic syndrome (modified Adult Treatment Panel III criteria), and free cortisol index (total serum cortisol/cortisol binding globulin) were assessed. Results: Major depression was not associated with the metabolic syndrome (odds ratio [OR] = 1.16, 95% confidence interval [CI] = 0.54-2.49), but subthreshold depression was associated with a decreased odds (OR = 0.55, 95% CI = 0.37-0.82). Persons with higher levels of free cortisol index showed a higher odds of metabolic syndrome (OR per standard deviation increase = 1.21, 95% CI = 1.06-1.39). Conclusions: As persons with high-cortisol levels more often had metabolic syndrome, hypercortisolemia within depressed persons may increase the risk of metabolic syndrome. (Am J Geriatr Psychiatry 2009; 17: 716-721)
C1 [Vogelzangs, Nicole; Beekman, Aartjan T. F.; Bremmer, Marijke A.; Comijs, Hannie C.] Vrije Univ Amsterdam Med Ctr, Dept Psychiat, NL-1081 HL Amsterdam, Netherlands.
   [Vogelzangs, Nicole; Beekman, Aartjan T. F.; Dik, Miranda G.; Bremmer, Marijke A.; Comijs, Hannie C.; Deeg, Dorly J. H.; Penninx, Brenda W. J. H.] Vrije Univ Amsterdam Med Ctr, EMGO Inst Hlth & Care Res, NL-1081 HL Amsterdam, Netherlands.
C3 Vrije Universiteit Amsterdam; VU UNIVERSITY MEDICAL CENTER; Vrije
   Universiteit Amsterdam; VU UNIVERSITY MEDICAL CENTER
RP Vogelzangs, N (corresponding author), Vrije Univ Amsterdam Med Ctr, Dept Psychiat, AJ Ernststr 887, NL-1081 HL Amsterdam, Netherlands.
EM n.vogelzangs@ggzingeest.nl
RI Beekman, Aartjan T./LUZ-6919-2024; Penninx, Brenda/S-7627-2017
OI Bremmer, Marijke/0000-0002-0415-1127; Hoogendijk,
   Witte/0000-0002-0225-4966
FU NHLBI NIH HHS [R01 HL72972-01] Funding Source: Medline
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NR 20
TC 38
Z9 40
U1 0
U2 15
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1064-7481
EI 1545-7214
J9 AM J GERIAT PSYCHIAT
JI Am. J. Geriatr. Psychiatr.
PD AUG
PY 2009
VL 17
IS 8
BP 716
EP 721
DI 10.1097/JGP.0b013e3181aad5d7
PG 6
WC Geriatrics & Gerontology; Gerontology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Psychiatry
GA 476GW
UT WOS:000268428000011
PM 19625789
DA 2025-06-11
ER

PT J
AU Turan, B
   Siva, ZO
   Uluduz, D
   Konukoglu, D
   Erenler, F
   Saip, S
   Goksan, B
   Siva, A
AF Turan, Bulent
   Siva, Zeynep Osar
   Uluduz, Derya
   Konukoglu, Dildar
   Erenler, Feyza
   Saip, Sabahattin
   Goksan, Baki
   Siva, Aksel
TI The impact of depression and ghrelin on body weight in migraineurs
SO JOURNAL OF HEADACHE AND PAIN
LA English
DT Article
DE Body weight; Ghrelin; Migraine; Psychiatric comorbidity; Depression;
   Anxiety
ID METABOLIC SYNDROME; OBESITY; ANXIETY; HEADACHE; COMORBIDITY; STRESS;
   RISK; PAIN
AB Comorbidity of migraine with anxiety and depression may play a role in the link between migraine and obesity. We examined the moderating and mediating roles of ghrelin in the relationship between depression (and anxiety) and body weight in newly diagnosed migraineurs.
   Participants were 63 newly diagnosed migraine patients (using the ICHD-II criteria) and 42 healthy volunteers. Body mass index (BMI) was calculated by measuring height and weight. Ghrelin was assessed at fasting. Depression was assessed with the Hamilton Depression scale, and anxiety with the Hamilton Anxiety scale.
   The data did not support the mediating role of ghrelin in the relationship between depression (or anxiety) and BMI for either the migraine or the control group. The interaction between ghrelin and depression as well as anxiety was significant for the migraine group, but not for the control group. Depressed (or anxious) migraineurs had a positive association between ghrelin and BMI, whereas for the non-depressed (or non-anxious) migraineurs this association was negative.
   Depression and anxiety moderated the effect of ghrelin on BMI for migraineurs. Management of anxiety and depression might be regarded as part of migraine treatment.
C1 [Turan, Bulent] Univ Alabama Birmingham, Dept Psychol, Birmingham, AL 35294 USA.
   [Siva, Zeynep Osar] Istanbul Univ, Dept Internal Med, Cerrahpasa Med Sch, Istanbul, Turkey.
   [Uluduz, Derya; Saip, Sabahattin; Goksan, Baki; Siva, Aksel] Istanbul Univ, Dept Neurol, Cerrahpasa Med Sch, Istanbul, Turkey.
   [Konukoglu, Dildar] Istanbul Univ, Dept Biochem, Cerrahpasa Med Sch, Istanbul, Turkey.
   [Erenler, Feyza] Istanbul Univ, Cerrahpasa Med Sch, Istanbul, Turkey.
C3 University of Alabama System; University of Alabama Birmingham; Istanbul
   University; Istanbul University - Cerrahpasa; Istanbul University;
   Istanbul University - Cerrahpasa; Istanbul University; Istanbul
   University - Cerrahpasa; Istanbul University; Istanbul University -
   Cerrahpasa
RP Uluduz, D (corresponding author), Istanbul Univ, Dept Neurol, Cerrahpasa Med Sch, Istanbul, Turkey.
EM deryaulu@yahoo.com
RI SAİP, SABAHATTİN/AAE-2410-2021; Erenler, Feyza/ABB-7806-2021; Konukoglu,
   Dildar/D-4951-2019; Siva, Aksel/A-5132-2016
OI Erenler, Feyza/0000-0002-7677-6556; Siva, Aksel/0000-0002-8340-6641;
   Konukoglu, Dildar/0000-0002-6095-264X; Turan, Bulent/0000-0003-2008-227X
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NR 35
TC 3
Z9 3
U1 0
U2 8
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1129-2369
EI 1129-2377
J9 J HEADACHE PAIN
JI J. Headache Pain
PD APR 24
PY 2014
VL 15
AR 23
DI 10.1186/1129-2377-15-23
PG 7
WC Clinical Neurology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA AH6FU
UT WOS:000336226900001
PM 24762133
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Suárez-Cuenca, JA
   Domínguez-Pérez, GA
   Hernández-Muñóz, RE
   Hernández-Patricio, A
   Vera-Gómez, E
   Gutiérrez-Buendfa, JA
   Salamanca-García, M
   Montoya-Ramírez, J
   Gaytán-Fuentes, OF
   Aranda-Rodríguez, C
   Rojas-Noverón, AR
   García, S
   Mondragón-Terán, P
AF Suarez-Cuenca, Juan Antonio
   Dominguez-Perez, Gabriela A.
   Hernandez-Munoz, Rolando E.
   Hernandez-Patricio, Alejandro
   Vera-Gomez, Eduardo
   Gutierrez-Buendia, Juan A.
   Salamanca-Garcia, Moises
   Montoya-Ramirez, Jesus
   Gaytan-Fuentes, Omar F.
   Aranda-Rodriguez, Carolina
   Rojas-Noveron, Amy R.
   Garcia, Silvia
   Mondragon-Teran, Paul
TI Nonalcoholic Fatty Liver Disease Severity Is Related to Plasma
   Pro-Oxidative Biomarkers Rather Than Liver Tissue-Measured Nitrogen
   Metabolism Biomarkers in Population with Obesity and Metabolic Syndrome
SO METABOLIC SYNDROME AND RELATED DISORDERS
LA English
DT Article
DE pro-oxidative biomarkers; nitrogen metabolism; NAFLD progression;
   obesity; metabolic syndrome
ID PATHOGENESIS; UNHEALTHY; NITRITE; NITRATE; STRESS
AB Background: The metabolic syndrome (MS) is associated with an increased production of nitrogen metabolites and elevated oxidative stress, which favors progression of nonalcoholic fatty liver disease (NAFLD). Subjects with the phenotype known as metabolically unhealthy obese (MUO) meet most of the MS cardiometabolic risk criteria and show a higher risk of advanced NAFLD severity, compared with the so-widely known metabolically healthy obese (MHO). Obese individuals with MS are more susceptible to abnormal lipid accumulation in different tissues, whereas oxidative stress and nitrogen metabolites are increased in MS and/or obesity. This study aimed to explore whether plasma- or liver tissue-determined biomarkers of nitrogen metabolism and oxidative stress relate to NAFLD severity and/or metabolic phenotype.Methods: This cross-sectional study included candidates for bariatric surgery with biopsy-proven NAFLD diagnosis and staging. For comparison, the study population was divided according to NAFLD damage (steatohepatitis F0-F1 vs. steatohepatitis F2-F4) and metabolic phenotype (MHO vs MUO, based on the MS criteria). Hepatic and plasma concentrations of nitrogen metabolites and oxidative stress biomarkers were determined by enzymatic kinetics assays, enzyme-linked immunosorbent assay, and Greiss reaction.Results: The study population (N = 45) was constituted by patients with obesity and higher prevalence of dyslipidemia, diabetes mellitus, and hypertension. According to plasma biomarkers, MUO phenotype was related to higher cardiometabolic risk; meanwhile, advanced NAFLD damage was related to higher glycated hemoglobin (HbA1c) and triglycerides. Elevated hepatic concentrations of ammonium, nitrites, arginine, and citrulline were found in MUO phenotype, but only higher plasma concentration of malondialdehyde was found as specifically related to advanced NAFLD damage.Conclusions: Circulating biomarkers of redox state were selectively related to advanced NAFLD damage, suggesting prognostic and therapeutic targets. Hepatic concentrations of nitrogen metabolism biomarkers may be more related to cardiometabolic risk.
C1 [Suarez-Cuenca, Juan Antonio; Dominguez-Perez, Gabriela A.; Hernandez-Patricio, Alejandro; Vera-Gomez, Eduardo; Gutierrez-Buendia, Juan A.; Aranda-Rodriguez, Carolina; Rojas-Noveron, Amy R.] Ctr Med Nacl 20 Noviembre ISSSTE, Lab Expt Metab & Clin Res, Mexico City, DF, Mexico.
   [Suarez-Cuenca, Juan Antonio; Garcia, Silvia] Ctr Med Nacl 20 Noviembre ISSSTE, Dept Clin Res, Div Invest, Mexico City, DF, Mexico.
   [Suarez-Cuenca, Juan Antonio] Hosp Gen Zona 32 Dr Mario Madrazo Navarro, IMSS, Mexico City, DF, Mexico.
   [Hernandez-Munoz, Rolando E.] Univ Nacl Autonoma Mexico, Inst Cellular Phyosiol, Cellular & Dev Biol Dept, Ciudad Univ, Mexico City, DF, Mexico.
   [Salamanca-Garcia, Moises] Ctr Med Nacl 20 Noviembre ISSSTE, Dept Pathol, Mexico City, DF, Mexico.
   [Montoya-Ramirez, Jesus; Gaytan-Fuentes, Omar F.] Ctr Med Nacl 20 Noviembre ISSSTE, Dept Bariatr Surg, Mexico City, DF, Mexico.
   [Mondragon-Teran, Paul] Ctr Med Nacl 20 Noviembre ISSSTE, Res Coordinat, Mexico City, DF, Mexico.
C3 Instituto Mexicano del Seguro Social; Universidad Nacional Autonoma de
   Mexico
RP Suárez-Cuenca, JA (corresponding author), Lab Expt Metab & Clin Res, Edificio D,Torre Invest,San Lorenzo 502, Mexico City 03100, DF, Mexico.
EM suarej05@gmail.com
RI SUAREZ-CUENCA, JUAN ANTONIO/KDN-6773-2024
OI GAYTAN FUENTES, OMAR FELIPE/0000-0001-7813-4314; Mondragon-Teran,
   Paul/0000-0003-0940-3626; Suarez-Cuenca, Juan
   Antonio/0000-0002-2098-5658; Rojas Noveron, Amy Ruby/0000-0003-3350-7986
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NR 29
TC 1
Z9 1
U1 0
U2 5
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-4196
EI 1557-8518
J9 METAB SYNDR RELAT D
JI Metab. Syndr. Relat. Disord.
PD MAR 1
PY 2023
VL 21
IS 2
BP 115
EP 121
DI 10.1089/met.2022.0007
EA FEB 2023
PG 7
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 9V2BN
UT WOS:000932293600001
PM 36787445
DA 2025-06-11
ER

PT J
AU Betul, T
   Vasfiye, K
   Ugur, K
   Ilknur, KA
AF Betul, Tas
   Vasfiye, Kabeloglu
   Ugur, Kacmaz
   Ilknur, Kivanc Altunay
TI Sleep, eating and psychopathologies: Which one(s) may be associated with
   the development of metabolic syndrome in psoriasis patients through
   psoriasis quality of life?
SO NEUROLOGY ASIA
LA English
DT Article
DE Psoriasis; metabolic syndrome; eating disorders; sleep quality;
   psychopathology
ID BODY-IMAGE; TURKISH; VALIDITY; ANXIETY; ADAPTATION; PREVALENCE;
   DISORDERS
AB Background: Psoriasis (PS) has many comorbidities including metabolic-syndrome (MetS) sleep and eating disorders and psychopathologies. Objectives: Investigating the relationship between the presence of MetS and sleep, eating and psychological pathologies in PS-patients through psoriasis quality of life (PSQoL). Methods: In this cross-sectional and descriptive correlation study, besides demographics, MetS-parameters and comorbidities, PS-severity, PS related quality of life (PSQoL), sleep-quality (SQ), depression, anxiety, body image-related QoL (BIQoL), perceived stress, flourishing, social appearance anxiety and eating attitudes of subjects were examined with related scales. Data analyzed using SPSS software, according to two PS groups with and without MetS. Results: Of 107 PS-patients, 68 were diagnosed with MetS. Meanage and PS-duration were significantly higher in MetS (+) group. PS severity was correlated with poor PSQoL, anxiety, depression, impairing flourishing, poor overall SQ and impairing in two sleep-subcomponents in MetS (+) group, whereas it was correlated with only poor PSQoL and poor overal SQ in MetS (-) group. Poor PSQoL was correlated with anxiety, depression, poor BIQoL, poor overal SQ and impairing in three sleep-subcomponents in MetS (+) group, whereas no correlation was found between these parameters and PSQoL in MetS(-) group.Conclusions: MetS is seen at high-rate in patients with long-term PS. PS-severity is especially correlated with anxiety, impaired-flourishing, and impaired-SQ in PS-patients with Mets (+). PSQoL appear to be correlated with depression, anxiety, distorted-BI and impaired SQ in these patients. It should be kept in mind that neuropsychological factors may facilitate the development of dysmetabolic events in PS-patients, by impairing PSQoL.
C1 [Betul, Tas] Univ Hlth Sci, Istanbul Bagcilar Training & Res Hosp, Dept Dermatol & Venereol, Bagcilar Istanbul, Turkiye.
   [Vasfiye, Kabeloglu] Univ Hlth Sci, Dept Neurol, Bakirkoy Prof Dr Mazhar Osman Training & Res Hosp, Bakirkoy Istanbul, Turkiye.
   [Ugur, Kacmaz] Univ Hlth Sci, Hamidiye Hlth Sci Inst, Dept Addict & Fight Addict, Haydarpasa Istanbul, Turkiye.
   [Ilknur, Kivanc Altunay] Univ Hlth Sci, Sisli Hamidiye Etfal Training & Res Hosp, Dept Dermatol, Sisli Istanbul, Turkiye.
   [Betul, Tas] Univ Hlth Sci, Istanbul Bagcilar Training & Res Hosp, Dept Dermatol & Venereol, TR-34200 Bagcilar Istanbul, Turkiye.
C3 Istanbul Bagcilar Training & Research Hospital; Istanbul Bakirkoy Mental
   Health & Neurology Training & Research Hospital; Istanbul Sisli Hamidiye
   Etfal Training & Research Hospital; Istanbul Bagcilar Training &
   Research Hospital
RP Betul, T (corresponding author), Univ Hlth Sci, Istanbul Bagcilar Training & Res Hosp, Dept Dermatol & Venereol, TR-34200 Bagcilar Istanbul, Turkiye.
EM betulavc@yahoo.com
RI kivanc altunay, ilknur/E-7490-2016
OI Kivanc Altunay, Ilknur/0000-0002-1354-7123; kabeloglu,
   vasfiye/0000-0002-1686-6437; KACMAZ, UGUR/0000-0001-9051-3130
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NR 34
TC 0
Z9 0
U1 0
U2 2
PU ASEAN NEUROLOGICAL ASSOC
PI KUALA LUMPUR
PA UNIV MALAYA MEDICAL CENTRE, NEUROLOGY LABORATORY, KUALA LUMPUR, 59100,
   MALAYSIA
SN 1823-6138
J9 NEUROL ASIA
JI Neurol. Asia
PD SEP
PY 2023
VL 28
IS 3
BP 707
EP 717
DI 10.54029/2023taf
PG 11
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA U5SF6
UT WOS:001085393800027
OA Bronze
DA 2025-06-11
ER

PT J
AU Fatima, S
   Khan, DA
   Aamir, M
   Pervez, MA
   Fatima, F
AF Fatima, Safia
   Khan, Dilshad Ahmad
   Aamir, Muhammad
   Pervez, Muhammad Amjad
   Fatima, Fozia
TI δ-Tocotrienol in Combination with Resveratrol Improves the
   Cardiometabolic Risk Factors and Biomarkers in Patients with Metabolic
   Syndrome: A Randomized Controlled Trial
SO METABOLIC SYNDROME AND RELATED DISORDERS
LA English
DT Article
DE metabolic syndrome; cardiometabolic risk factors; central obesity;
   insulin resistance; delta-tocotrienol; resveratrol
ID OXIDATIVE STRESS
AB Background: Metabolic syndrome (MetS) is a cluster of central obesity, hypertension, hyperglycemia, and dyslipidemia. It is a global health issue with an increased risk of cardiovascular disease. Recently, a few natural products have been reported with promising anti-inflammatory and antioxidative effects. We aimed to evaluate the impact of delta-tocotrienol and resveratrol mixture (TRM) supplementation on cardiometabolic risk factors and biomarkers in patients with MetS. Methods: A randomized controlled trial was conducted at the hospitals of National University of Medical Sciences Rawalpindi, Pakistan. A total of 82 patients with MetS aged 18-60 years were enrolled based on International Diabetes Federation-2005 diagnostic criteria and randomly grouped into TRM (n = 41) and placebo (n = 41). Patients in the TRM group were given a 400 mg capsule (delta-tocotrienol 250 mg; resveratrol 150 mg), and a placebo (cellulose 400 mg) twice daily for 24 weeks. The biochemical tests were analyzed on ADVIA 1800 Chemistry (R) analyzer and inflammatory biomarkers by ELISA methods. Results: In the TRM group, a significant reduction in waist circumference, blood pressure, mean (95% confidence interval) of fasting plasma glucose -0.15 mmol/L (-0.22 to -0.08), serum triglyceride -0.32 mmol/L (-0.47 to -0.17), and increment in high-density lipoprotein cholesterol were observed as compared with placebo. TRM supplementation also improved biomarkers: high-sensitive C-reactive protein -0.61 mg/L (-0.89 to -0.33), interleukin-6-1.99 pg/mL (-2.50 to -1.48), tumor necrosis factor-alpha -2.19 pg/mL (-2.55 to -1.83), malondialdehyde -0.48 mu mol/L (-0.65 to -0.30), and total antioxidant capacity 1.71 U/mL (1.29 to 2.13). Conclusion: TRM supplementations improved cardiometabolic risk factors and biomarkers of inflammation and oxidative stress without any significant side effects in the patients with MetS.
C1 [Fatima, Safia; Khan, Dilshad Ahmad; Aamir, Muhammad; Pervez, Muhammad Amjad] Natl Univ Med Sci NUMS, Armed Forces Inst Pathol AFIP, Dept Chem Pathol, Rawalpindi, Pakistan.
   [Fatima, Fozia] Natl Univ Med Sci NUMS, Dept Hlth Profess Educ, Rawalpindi, Pakistan.
   [Fatima, Safia] Natl Univ Med Sci NUMS, Armed Forces Inst Pathol AFIP, Dept Chem Pathol, Rawalpindi 46000, Pakistan.
RP Fatima, S (corresponding author), Natl Univ Med Sci NUMS, Armed Forces Inst Pathol AFIP, Dept Chem Pathol, Rawalpindi 46000, Pakistan.
EM sofy_asim@hotmail.com
RI Fatima, Safia/GWZ-2980-2022; fatima, fozia/S-7949-2019; Aamir,
   Muhammad/HMD-8149-2023
OI Fatima, Dr Fozia/0000-0001-8237-5313
FU Department of Nutrition, Combined Military Hospital, Rawalpindi,
   Pakistan
FX We thank RDN Madam Musarrat Bhatti from the Department of Nutrition,
   Combined Military Hospital, Rawalpindi, Pakistan, for sincere support at
   the initial screening of this research study and staff at Armed Forces
   Institute of Pathology, Rawalpindi, Pakistan, who helped with the
   laboratory analysis.
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NR 28
TC 12
Z9 12
U1 0
U2 3
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-4196
EI 1557-8518
J9 METAB SYNDR RELAT D
JI Metab. Syndr. Relat. Disord.
PD FEB 1
PY 2023
VL 21
IS 1
BP 25
EP 34
DI 10.1089/met.2022.0052
EA SEP 2022
PG 10
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 8U3QE
UT WOS:000856060300001
PM 36125447
DA 2025-06-11
ER

PT J
AU Costabile, G
   Della Pepa, G
   Bozzetto, L
   Annuzzi, G
   Vetrani, C
   Giacco, R
   Della Corte, G
   Conte, FS
   Di Marino, L
   Rivellese, AA
AF Costabile, Giuseppina
   Della Pepa, Giuseppe
   Bozzetto, Lutgarda
   Annuzzi, Giovanni
   Vetrani, Claudia
   Giacco, Rosalba
   Della Corte, Giuseppina
   Conte, Francesca Serena
   Di Marino, Lucrezia
   Rivellese, Angela Albarosa
TI Urine 8-Isoprostane in Relation to Adiposity and Insulin Resistance in
   Individuals at High Cardiometabolic Risk
SO METABOLIC SYNDROME AND RELATED DISORDERS
LA English
DT Article
ID OXIDATIVE STRESS; LIPID-PEROXIDATION; METABOLIC SYNDROME; OXIDANT
   STRESS; IN-VIVO; MARKERS; ISOPROSTANES; OBESITY; DISEASE; DAMAGE
AB Background: Oxidative stress has been implicated in the pathogenesis of many conditions, including insulin resistance and obesity. However, in vivo data concerning these relationships are scarce and conflicting. Therefore, the aim of this study was to investigate the association of oxidative stress with abdominal adiposity and insulin resistance in individuals at high cardiometabolic risk.
   Methods: A total of 116 overweight/obese individuals participating in the HealthGrain and Etherpaths European Projects, having waist circumference (WC) and any other component of the metabolic syndrome, were included in this cross-sectional evaluation. 8-Isoprostane concentrations in 24-hr urine were measured as marker of oxidative stress in vivo. Baseline anthropometric and metabolic parameters were analyzed according to quartiles of 8-isoprostanes. Linear regression (LR) analysis was used to assess clinical correlates of oxidative stress.
   Results: Urinary 8-isoprostane levels were 52% higher in men than in women (P<0.001). Across the isoprostanes quartiles, there was a significant increase in WC and body weight [P for trend <0.001; analysis of variance (ANOVA) P<0.001] and fasting triglycerides (P for trend P<0.05), and a significant decrease in high-density lipoprotein cholesterol (P for trend P=0.001). No significant association between urinary isoprostane concentrations and insulin resistance [homeostasis model assessment of insulin resistance (HOMA-IR)] was found. WC circumference and body weight remained significant after adjustment for age and gender (P=0.023 and P=0.014, respectively) and independently associated with isoprostanes at LR (P<0.005 for both).
   Conclusions: Central obesity was independently associated with oxidative stress even in a population homogeneous for adiposity and cardiometabolic risk, whereas no relationship was observed between oxidative stress and insulin resistance.
C1 [Costabile, Giuseppina; Della Pepa, Giuseppe; Bozzetto, Lutgarda; Annuzzi, Giovanni; Vetrani, Claudia; Della Corte, Giuseppina; Conte, Francesca Serena; Di Marino, Lucrezia; Rivellese, Angela Albarosa] Univ Naples Federico II, Dept Clin Med & Surg, I-80131 Naples, Italy.
   [Costabile, Giuseppina; Giacco, Rosalba] CNR, Inst Food Sci, Avellino, Italy.
C3 University of Naples Federico II; Consiglio Nazionale delle Ricerche
   (CNR); Istituto di Scienze dell' Alimentazione (ISA-CNR)
RP Rivellese, AA (corresponding author), Univ Naples Federico II, Dept Clin Med & Surg, Via Pansini 5, I-80131 Naples, Italy.
EM rivelles@unina.it
RI Bozzetto, Lutgarda/E-6271-2012; Costabile, Giuseppina/K-4589-2016; Della
   Pepa, Giuseppe/AAK-5488-2020; Vetrani, Claudia/D-3306-2018
OI Bozzetto, Lutgarda/0000-0001-6549-4476; Vetrani,
   Claudia/0000-0001-8335-5939; Costabile, Giuseppina/0000-0001-5761-8002;
   Della Pepa, Giuseppe/0000-0001-5862-3794; Giacco,
   Rosalba/0000-0002-4006-9761
FU European Commission [FOOD CT 2005 514008, FP7-KBBE-222639]; Ministero
   dell'Istruzione, dell'Universita e della Ricerca, Italy, PRIN
   [2010JCWWKM]
FX This research received funding from the European Commission, 6th
   Framework Programme, HEALTHGRAIN Project (FOOD CT 2005 514008), the 7th
   Framework Programme, ETHERPATHS Project (FP7-KBBE-222639), and Ministero
   dell'Istruzione, dell'Universita e della Ricerca, Italy, PRIN n.
   2010JCWWKM.
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NR 26
TC 13
Z9 14
U1 0
U2 0
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-4196
EI 1557-8518
J9 METAB SYNDR RELAT D
JI Metab. Syndr. Relat. Disord.
PD MAY 1
PY 2015
VL 13
IS 4
BP 187
EP 191
DI 10.1089/met.2014.0119
PG 5
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA CG6DU
UT WOS:000353386800006
PM 25714911
DA 2025-06-11
ER

PT J
AU Epel, ES
   Lin, J
   Wilhelm, FH
   Wolkowitz, OM
   Cawthon, R
   Adler, NE
   Dolbier, C
   Mendes, WB
   Blackburn, EH
AF Epel, ES
   Lin, J
   Wilhelm, FH
   Wolkowitz, OM
   Cawthon, R
   Adler, NE
   Dolbier, C
   Mendes, WB
   Blackburn, EH
TI Cell aging in relation to stress arousal and cardiovascular disease risk
   factors
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE telomerase; telomere length; stress; heart rate variability; stress
   hormones; metabolic syndrome
ID INSULIN-RESISTANCE; METABOLIC SYNDROME; OXIDATIVE STRESS; TELOMERE
   LENGTH; MORTALITY; INCREASE; PEOPLE
AB We previously reported that psychological stress is linked to and possibly accelerates cellular aging, as reflected by tower PBMC telomerase and shortened tetomeres. Psychological stress is a major risk factor for cardiovascular disease (CVD), with multiple behavioral and physiological mediators. Telomere shortness has been associated with CVD, but the relationship between tow telomerase activity, a potential precursor to telomere shortening, and CVD risk factors has not been examined in humans. Here we examine whether telomere length and telomerase in leukocytes are associated with physiological signs of stress arousal and CVD risk factors in 62 healthy women. Low telomerase activity in Leukocytes was associated with exaggerated autonomic reactivity to acute mentat stress and elevated nocturnal epinephrine. Further, tow telomerase activity was associated with the major risk factors for CVD -smoking, poor lipid profile, high systolic blood pressure, high fasting glucose, greater abdominal adiposity-as well as to a composite Metabolic Syndrome variable. Telomere length was related only to elevated stress hormones (catecholamines and cortisol). Thus, we propose that low leukocyte telomerase constitutes an early marker of CVD risk, possibly preceding shortened telomeres, that results in part from chronic stress arousal. Possible cellular mechanisms by which Low telomerase may link stress and traditional risk factors to CVD are discussed. These findings may implicate telomerase as a novel and important mediator of the effects of psychological stress on physical health and disease. (C) 2005 Elsevier Ltd. All rights reserved.
C1 Univ Calif San Francisco, Dept Psychiat, San Francisco, CA 94143 USA.
   Univ Calif San Francisco, Dept Biochem & Biophys, San Francisco, CA 94143 USA.
   Univ Basel, Dept Clin Psychol & Psychotherapy, Basel, Switzerland.
   E Carolina Univ, Dept Psychol, Greenville, NC 27858 USA.
   Univ Utah, Dept Human Genet, Salt Lake City, UT USA.
   Harvard Univ, Dept Psychol, Cambridge, MA 02138 USA.
C3 University of California System; University of California San Francisco;
   University of California System; University of California San Francisco;
   University of Basel; University of North Carolina; East Carolina
   University; Utah System of Higher Education; University of Utah; Harvard
   University
RP Univ Calif San Francisco, Dept Psychiat, 3333 Calif St,Suite 465, San Francisco, CA 94143 USA.
EM epele@healthpsych.ucsf.edu
RI Epel, Elissa/ABI-6703-2022; Adler, Nancy/ABR-3334-2022; Wilhelm,
   Frank/AHB-4432-2022; Wolkowitz, Owen/J-6649-2013
OI Wilhelm, Frank H./0000-0002-4414-7085
FU NCRR NIH HHS [M01-RR01271] Funding Source: Medline; NIGMS NIH HHS
   [GM26259] Funding Source: Medline; NIMH NIH HHS [K08 MH64110-01A1]
   Funding Source: Medline
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NR 39
TC 369
Z9 422
U1 1
U2 41
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD APR
PY 2006
VL 31
IS 3
BP 277
EP 287
DI 10.1016/j.psyneuen.2005.08.011
PG 11
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA 024HQ
UT WOS:000236186500001
PM 16298085
DA 2025-06-11
ER

PT J
AU Pham, H
   Svensson, T
   Chung, UI
   Svensson, AK
AF Pham, Helena
   Svensson, Thomas
   Chung, Ung-Il
   Svensson, Akiko Kishi
TI Sleep Satisfaction May Modify the Association between Metabolic Syndrome
   and BMI, Respectively, and Occupational Stress in Japanese Office
   Workers
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Article
DE the Brief Job Stress Questionnaire; psychological stress; occupational
   stress; obesity; risk factor; occupational cohort; metabolic syndrome
ID BODY-MASS INDEX; PSYCHOLOGICAL STRESS; LEPTIN LEVELS; OBESITY; QUALITY;
   HEALTH; RISK; DURATION; COHORT; TOOL
AB The association between obesity and psychological stress is ambiguous. The aim is to investigate the association between metabolic syndrome (MetS) and body mass index (BMI), respectively, with occupational stress among Japanese office workers. The study is a secondary analysis of the intervention group from a randomized controlled trial. There are 167 participants included in the analysis. Occupational stress is self-reported using the Brief Job Stress Questionnaire (BJSQ). BMI and the classification of MetS/pre-MetS was based on the participants' annual health check-up data. The primary exposure is divided into three groups: no MetS, pre-MetS, and MetS in accordance with Japanese guidelines. The secondary exposure, BMI, remains as a continuous variable. Multiple linear regression is implemented. Sensitivity analyses are stratified by sleep satisfaction. Pre-MetS is significantly associated with occupational stress (7.84 points; 95% CI: 0.17, 15.51). Among participants with low sleep satisfaction, pre-MetS (14.09 points; 95% CI: 1.71, 26.48), MetS (14.72 points; 95% CI: 0.93, 28.51), and BMI (2.54 points; 95% CI: 0.05, 4.99) are all significantly associated with occupational stress. No significant associations are observed in participants with high sleep satisfaction. The findings of this study indicate that sleep satisfaction may modify the association between MetS and BMI, respectively, and occupational stress.
C1 [Pham, Helena; Svensson, Thomas; Chung, Ung-Il; Svensson, Akiko Kishi] Univ Tokyo, Grad Sch Engn, Dept Bioengn, Precis Hlth,Bunkyo Ku, 7-3-1 Hongo, Tokyo 1138656, Japan.
   [Pham, Helena; Svensson, Thomas; Svensson, Akiko Kishi] Lund Univ, Skane Univ Hosp, Dept Clin Sci, S-20502 Malmo, Sweden.
   [Svensson, Thomas; Chung, Ung-Il] Kanagawa Univ Human Serv, Sch Hlth Innovat, Grad Sch, Kawasaki Ku, Res Gate Bldg Tonomachi 2-A 2,3F,3-25-10 Tonomach, Kawasaki, Kanagawa 2100821, Japan.
   [Chung, Ung-Il] Univ Tokyo, Ctr Dis Biol & Integrat Med, Grad Sch Med, Clin Biotechnol,Bunkyo Ku, 7-3-1 Hongo, Tokyo 1138655, Japan.
   [Svensson, Akiko Kishi] Univ Tokyo, Dept Diabet & Metab Dis, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1130033, Japan.
C3 University of Tokyo; Lund University; Skane University Hospital;
   University of Tokyo; University of Tokyo
RP Svensson, T (corresponding author), Univ Tokyo, Grad Sch Engn, Dept Bioengn, Precis Hlth,Bunkyo Ku, 7-3-1 Hongo, Tokyo 1138656, Japan.; Svensson, T (corresponding author), Lund Univ, Skane Univ Hosp, Dept Clin Sci, S-20502 Malmo, Sweden.; Svensson, T (corresponding author), Kanagawa Univ Human Serv, Sch Hlth Innovat, Grad Sch, Kawasaki Ku, Res Gate Bldg Tonomachi 2-A 2,3F,3-25-10 Tonomach, Kawasaki, Kanagawa 2100821, Japan.
EM helena.pt100@gmail.com; thomas.svensson@med.lu.se;
   helixcm1@g.ecc.u-tokyo.ac.jp; kishi@bioeng.t.u-tokyo.ac.jp
RI Svensson, Thomas/AAJ-4578-2020
FU Center of Innovation Program from the Japan Science and Technology
   Agency, JST [JPMJCE1304]; Kanagawa prefecture's "A project to expand the
   use of metabolic syndrome risk index in municipalities" (2018)
FX This research was supported by the Center of Innovation Program from the
   Japan Science and Technology Agency, JST (Grant Number JPMJCE1304) and
   Kanagawa prefecture's "A project to expand the use of metabolic syndrome
   risk index in municipalities" (2018).
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NR 56
TC 1
Z9 1
U1 1
U2 7
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD MAY
PY 2022
VL 19
IS 9
AR 5095
DI 10.3390/ijerph19095095
PG 12
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA 1E3KE
UT WOS:000794391200001
PM 35564491
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Chao, AM
   Wadden, TA
   Berkowitz, RI
AF Chao, Ariana M.
   Wadden, Thomas A.
   Berkowitz, Robert I.
TI Obesity in Adolescents with Psychiatric Disorders
SO CURRENT PSYCHIATRY REPORTS
LA English
DT Review
DE Adolescence; Obesity; Psychiatric disorders; Depression; Bipolar
   disorder; Schizophrenia
ID BODY-MASS INDEX; WEIGHT-GAIN; DOUBLE-BLIND; PHARMACOLOGICAL-TREATMENT;
   DEPRESSIVE SYMPTOMS; CHILDHOOD OBESITY; BIPOLAR DISORDER; MENTAL-HEALTH;
   CARDIOMETABOLIC RISK; BARIATRIC SURGERY
AB Purpose of ReviewThis narrative review synthesized recent research related to obesity in adolescents with psychiatric disorders, with a focus on epidemiology, mechanisms, and weight management approaches. The paper reviews literature on depressive and anxiety disorders, bipolar disorder, and schizophrenia spectrum and other psychotic disorders.Recent FindingsDepression has a bidirectional relationship with obesity. Bipolar disorder and schizophrenia spectrum disorders, and their treatments, increase the risk of developing obesity. Mechanisms underlying this weight gain include lifestyle and environmental factors and psychiatric medications, though emerging evidence has also suggested the role of genetic and neuroendocrine processes. Evidence about the most effective treatments for obesity in adolescents with psychiatric disorders remains limited.SummaryAdolescents with psychiatric disorders are at high risk for obesity. Close monitoring for increases in weight and cardiometabolic risk factors with use of antipsychotic and mood-stabilizing medications is recommended. Clinical trials are needed that test the efficacy of weight management strategies for this population.
C1 [Chao, Ariana M.] Univ Penn, Sch Nursing, Dept Biobehav Hlth Sci, Philadelphia, PA 19104 USA.
   [Chao, Ariana M.; Wadden, Thomas A.; Berkowitz, Robert I.] Univ Penn, Perelman Sch Med, Dept Psychiat, Philadelphia, PA 19104 USA.
   [Berkowitz, Robert I.] Childrens Hosp Philadelphia, Dept Child & Adolescent Psychiat & Behav Sci, 3440 Market St,Suite 200, Philadelphia, PA 19104 USA.
C3 University of Pennsylvania; University of Pennsylvania; University of
   Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia
RP Berkowitz, RI (corresponding author), Univ Penn, Perelman Sch Med, Dept Psychiat, Philadelphia, PA 19104 USA.; Berkowitz, RI (corresponding author), Childrens Hosp Philadelphia, Dept Child & Adolescent Psychiat & Behav Sci, 3440 Market St,Suite 200, Philadelphia, PA 19104 USA.
EM berkowitz@email.chop.edu
RI Cobden, David/AGL-5940-2022
OI Wadden, Thomas/0000-0002-0438-4609
FU National Institute of Nursing Research of the National Institutes of
   Health [K23NR017209]
FX Ariana M. Chao was supported, in part, by the National Institute of
   Nursing Research of the National Institutes of Health under Award Number
   K23NR017209. The content is solely the responsibility of the authors and
   does not necessarily represent the official views of the National
   Institutes of Health.
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NR 101
TC 61
Z9 67
U1 0
U2 24
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1523-3812
EI 1535-1645
J9 CURR PSYCHIAT REP
JI Curr. Psychiatry Rep.
PD JAN
PY 2019
VL 21
IS 1
AR 3
DI 10.1007/s11920-019-0990-7
PG 11
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA HI1GE
UT WOS:000456192100002
PM 30661128
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Phillips, CM
   Perry, IJ
AF Phillips, Catherine M.
   Perry, Ivan J.
TI Depressive symptoms, anxiety and well-being among metabolic health obese
   subtypes
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE Metabolically healthy obesity; Depressive symptoms; Anxiety; Well-being;
   Mental health; Inflammation
ID C-REACTIVE PROTEIN; INSULIN-RESISTANCE; CARDIOVASCULAR-DISEASE; HOSPITAL
   ANXIETY; RISK; ASSOCIATION; VALIDITY; METAANALYSIS; ADULTS;
   IDENTIFICATION
AB Background: The metabolically healthy obese (MHO) phenotype is characterized by favorable lipid and inflammatory profiles, preserved insulin sensitivity and normal blood pressure. Limited data regards whether metabolically healthy obesity also confers beneficial effects on mental health and well-being exists.
   Methods: We investigated depressive symptoms, anxiety and well-being among metabolically healthy and unhealthy obese and non-obese adults from a cross-sectional sample of 2047 middle-aged Irish men and women. Subjects were classified as obese (BMI >= 30 kg/m(2)) and non-obese (BMI <30 kg/m(2)). Metabolic health status was defined using three metabolic health definitions based on a range of cardiometabolic abnormalities including metabolic syndrome criteria, insulin resistance and inflammation. Depressive symptoms, anxiety and well-being were assessed using the Center for Epidemiologic Studies Depression Scale (CES-D), the Hospital Anxiety and Depression Scale (HADS) and the World Health Organization (WHO)-5 Well Being Index.
   Results: Relative to the metabolically healthy non-obese individuals the risk of anxiety and depressive symptoms was greater among the metabolically unhealthy obese subjects (odds ratios (ORs) 1.63-1.66 and ORs 1.82-1.83 for anxiety and depressive symptoms, respectively depending on metabolic health definition). Increased risk of these conditions was not observed among the MHO subjects.
   Conclusions: Our data suggest that a favorable metabolic profile is positively associated with mental health among obese middle-aged adults, although findings were dependent on metabolic health definition. Improved understanding of the relationship between obesity associated metabolic health subtypes, anxiety and depressive symptoms may inform future targeted screening and interventions for those at greatest risk of adverse mental and cardiometabolic health outcomes. (C) 2015 Elsevier Ltd. All rights reserved.
C1 [Phillips, Catherine M.; Perry, Ivan J.] Natl Univ Ireland Univ Coll Cork, Dept Epidemiol & Publ Hlth, HRB Ctr Diet & Hlth Res, Cork, Ireland.
C3 Health Research Board - Ireland; University College Cork
RP Phillips, CM (corresponding author), Natl Univ Ireland Univ Coll Cork, Dept Epidemiol & Publ Hlth, HRB Ctr Diet & Hlth Res, Western Gateway Bldg, Cork, Ireland.
EM c.phillips@ucc.ie
RI Phillips, Catherine/E-4412-2013
OI Phillips, Catherine/0000-0003-4916-4463; Perry, Ivan/0000-0002-4965-9792
FU Irish Health Research Board [HRC/2007/13]
FX This work was supported by a research grant from the Irish Health
   Research Board (reference HRC/2007/13). This grant supported the
   recruitment and examination of the Mitchelstown cohort which forms the
   basis of this manuscript. The HRB was not involved in the study design,
   data collection, analysis or interpretation or in the writing of this
   manuscript.
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NR 38
TC 36
Z9 38
U1 1
U2 22
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD DEC
PY 2015
VL 62
BP 47
EP 53
DI 10.1016/j.psyneuen.2015.07.168
PG 7
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA CW5UU
UT WOS:000365062900006
PM 26232649
DA 2025-06-11
ER

PT J
AU Galeno, DML
   Peixoto, HJA
   Carneiro, BTS
   Leocadio-Miguel, MA
AF Galeno, D. M. L.
   Peixoto, H. J. A.
   Carneiro, B. T. S.
   Leocadio-Miguel, M. A.
TI Cardiometabolic risk factors and social jetlag in university professors
SO BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
LA English
DT Article
DE Stress; Social jetlag; Sleep; Cardiometabolic disorders; University
   professors
ID SLEEP DURATION; METABOLISM; QUALITY; OBESITY; STRESS; ADULT; TIME
AB Chronic stress leads to circadian disruption, with variability in sleep time and duration. This scenario increases the prevalence and incidence of cardiometabolic abnormalities. Social jetlag (SJL), a proxy of circadian disruption, has been associated with increased vulnerability to the development of metabolic syndrome, obesity, and type 2 diabetes. This research aimed to evaluate how variables associated with cardiometabolic risk are related to SJL and poor sleep among university professors. From 2018 to 2019, full-time university professors (n=103) with a mean age of 44 & PLUSMN;5.4 years were assessed for sleep quality, chronotype, SJL, metabolic components, sociodemographic characteristics, and physical evaluation. Sleep quality and weekday sleep duration were associated with stress (r=0.44 and r=-0.34) and anxiety (r=0.40), respectively. Mean sleep duration (n=65) was 7.0 & PLUSMN;1.1 h and all professors with poor sleep (41.2%; n=28) worked 40 h/week. Professors who slept less were significantly (r=-0.25) older, and teaching time (years) was positively correlated with blood glucose (r=0.42). Mean SJL was 59.8 & PLUSMN;4.5 min (n=68) and 48.5% of these professors had values p1 h and 51.4% X1 h. SJL and blood glucose concentration were associated (r=0.35), which reinforced that challenges to the circadian system reverberate on metabolism. In this study, professors at the Federal University of Rio Grande do Norte had cardiometabolic risks related to anxiety, stress, and sleep quality.
C1 [Galeno, D. M. L.; Peixoto, H. J. A.; Carneiro, B. T. S.; Leocadio-Miguel, M. A.] Univ Fed Rio Grande Do Norte, Dept Fisiol & Comportamento, Natal, RN, Brazil.
   [Leocadio-Miguel, M. A.] Northumbria Univ, Dept Psychol, Newcastle Upon Tyne, England.
C3 Universidade Federal do Rio Grande do Norte; Northumbria University
RP Galeno, DML (corresponding author), Univ Fed Rio Grande Do Norte, Dept Fisiol & Comportamento, Natal, RN, Brazil.
EM morais_denise@hotmail.com
RI Leocadio-Miguel, Mario/AAR-2747-2021; Miguel, Mario/E-1220-2012
OI Carneiro, Breno/0000-0001-6510-4503; Miguel, Mario/0000-0002-7248-3529
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NR 35
TC 4
Z9 4
U1 2
U2 5
PU ASSOC BRAS DIVULG CIENTIFICA
PI RIBEIRAO PRETO
PA FACULDADE MEDICINA, CASA 10, 14049 RIBEIRAO PRETO, RIBEIRAO PRETO, SP
   14049, BRAZIL
SN 0100-879X
EI 1414-431X
J9 BRAZ J MED BIOL RES
JI Brazilian J. Med. Biol. Res.
PY 2023
VL 56
AR e12539
DI 10.1590/1414-431X2023e12539
PG 8
WC Biology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics; Research & Experimental
   Medicine
GA L6AI7
UT WOS:001024067800001
PM 37403885
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Pervanidou, P
   Chrousos, GP
AF Pervanidou, Panagiota
   Chrousos, George P.
TI Stress and obesity/metabolic syndrome in childhood and adolescence
SO INTERNATIONAL JOURNAL OF PEDIATRIC OBESITY
LA English
DT Review
DE Anxiety; children; cortisol; depression; HPA axis; stress
ID CORTISOL CONCENTRATIONS; WEIGHT PERCEPTION; MAJOR DEPRESSION; OBESITY;
   DISORDER; ASSOCIATION; SYMPTOMS; CHILDREN; ANXIETY; SYSTEM
AB Chronic distress contributes to the development of obesity and comorbid states. Stress is the disturbance of the complex dynamic equilibrium that all organisms must maintain, and is associated with activation of the Stress system comprising of the hypothalamic-pituitary-adrenal axis and the arousal/sympathetic nervous systems. The stress system functions in a baseline circadian fashion and interacts with other systems of the organism to regulate a variety of behavioral, endocrine, metabolic, immune and cardiovascular functions. The experience of perceived or real uncontrollable intense and/or chronic stress (distress) may lead to several psychopathologic conditions, including anxiety, depressive and psychosomatic disorders, substance abuse, obesity and the metabolic syndrome, and osteoporosis, as well as impaired reproductive and immune functions. Developing children and adolescents are particularly vulnerable to the effects of chronic stress. Both behavioral and biological pathways are involved in the connection between chronic stress and obesity in adults and children. Emotional "comfort" eating, lack of sleep, impulsive behaviours and selection of specific foods often characterize stressed individuals. In addition to specific behaviours, dysregulation of the stress system through increased secretion of cortisol and catecholamines, especially in the evening hours, and in concert with concurrently elevated insulin concentrations, leads to development of central obesity, insulin resistance and the metabolic syndrome. In children, chronic alterations in cortisol secretion may have additional effects on cognitive and emotional development, timing of puberty and final stature. Obese children and adolescents are frequently entangled in a vicious cycle between distress, impairing self-image and distorted self-image, maintaining and worsening distress.
C1 [Pervanidou, Panagiota; Chrousos, George P.] Univ Athens, Sch Med, Dept Pediat 1, Aghia Sophia Childrens Hosp,Childhood Obes Clin, GR-11527 Athens, Greece.
C3 The Aghia Sophia Children's Hospital; Athens Medical School; National &
   Kapodistrian University of Athens
RP Pervanidou, P (corresponding author), Univ Athens, Sch Med, Dept Pediat 1, Aghia Sophia Childrens Hosp,Childhood Obes Clin, Thivon & Levadias Str, GR-11527 Athens, Greece.
EM ppervanid@med.uoa.gr
RI Pervanidou, Panagiota/ABI-6356-2020; Chrousos, George/G-8702-2011
OI Pervanidou, Panagiota/0000-0002-6593-6489
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   Schneider M, 2007, OBESITY, V15, P2328, DOI 10.1038/oby.2007.276
   Sjöberg RL, 2005, PEDIATRICS, V116, pE389, DOI 10.1542/peds.2005-0170
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NR 53
TC 111
Z9 121
U1 1
U2 57
PU INFORMA HEALTHCARE
PI LONDON
PA TELEPHONE HOUSE, 69-77 PAUL STREET, LONDON EC2A 4LQ, ENGLAND
SN 1747-7166
EI 1747-7174
J9 INT J PEDIATR OBES
JI Int. J. Pediatr. Obes.
PD SEP
PY 2011
VL 6
SU 1
BP 21
EP 28
DI 10.3109/17477166.2011.615996
PG 8
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Pediatrics
GA 819XM
UT WOS:000294867700004
PM 21905812
DA 2025-06-11
ER

PT J
AU Engum, A
AF Engum, Anne
TI The role of depression and anxiety in onset of diabetes in a large
   population-based study
SO JOURNAL OF PSYCHOSOMATIC RESEARCH
LA English
DT Article
DE anxiety; depression; diabetes; HADS; metabolic syndrome
ID HOSPITAL ANXIETY; INSULIN-RESISTANCE; RISK; SYMPTOMS; ADULTS;
   PREVALENCE; DISORDERS; ILLNESS; HISTORY; HEALTH
AB Objective: Recent research has shown that depression may predict incident diabetes. The aims of the study are to investigate if symptoms of depression and anxiety precede the onset of diabetes or vice versa and to examine if mediating factors may explain such associations. Methods: A prospective population-based study (N=37,291) investigating the associations between symptoms of depression/anxiety and diabetes was conducted. Results: Individuals reporting symptoms of depression and anxiety at baseline had increased risk of onset of type 2 diabetes at 10-year follow-up. No gender differences were found. The analyses did not reveal underlying factors that mediated the association. Baseline diagnosis of diabetes was not associated with subsequent symptoms of anxiety or depression among males or females. Conclusion: Diabetes did not predict symptoms of depression or anxiety. Symptoms of depression and anxiety emerged as significant risk factors for onset of type 2 diabetes independent of established risk factors for diabetes, such as socioeconomic factors, lifestyle factors, and markers of the metabolic syndrome. The comorbidity between depression and anxiety may be the most important factor. (c) 2007 Elsevier Inc. All rights reserved.
C1 Norwegian Univ Sci & Technol, Fac Med, Dept Neurosci, NO-7491 Trondheim, Norway.
   Hop Levanger, Nord Trondelag Hosp Trust, Dept Psychiat, Levanger, Norway.
C3 Norwegian University of Science & Technology (NTNU)
RP Engum, A (corresponding author), Norwegian Univ Sci & Technol, Fac Med, Dept Neurosci, NO-7491 Trondheim, Norway.
EM anne.engum@hnt.no
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NR 35
TC 223
Z9 260
U1 0
U2 23
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-3999
EI 1879-1360
J9 J PSYCHOSOM RES
JI J. Psychosomat. Res.
PD JAN
PY 2007
VL 62
IS 1
BP 31
EP 38
DI 10.1016/j.jpsychores.2006.07.009
PG 8
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 123UY
UT WOS:000243322800005
PM 17188118
DA 2025-06-11
ER

PT J
AU Heissel, A
   Zech, P
   Rapp, MA
   Schuch, FB
   Lawrence, JB
   Kangas, M
   Heinzel, S
AF Heissel, Andreas
   Zech, Philipp
   Rapp, Michael A.
   Schuch, Felipe B.
   Lawrence, Jimmy B.
   Kangas, Maria
   Heinzel, Stephan
TI Effects of exercise on depression and anxiety in persons living with
   HIV: A meta-analysis
SO JOURNAL OF PSYCHOSOMATIC RESEARCH
LA English
DT Review
DE HIV; Exercise; Depression; Anxiety; Meta-analysis; Supervision
ID QUALITY-OF-LIFE; RANDOMIZED CONTROLLED-TRIAL;
   HUMAN-IMMUNODEFICIENCY-VIRUS; AEROBIC EXERCISE; SYSTEMATIC REVIEWS;
   PHYSICAL-ACTIVITY; MENTAL-HEALTH; THERAPEUTIC EXERCISE; METABOLIC
   SYNDROME; STRESS-MANAGEMENT
AB Objective: The purpose of this systematic review and meta-analysis was to examine the effects of exercise on depression and anxiety in people living with HIV (PLWH), and to evaluate, through subgroup analysis, the effects of exercise type, frequency, supervision by exercise professionals, study quality, and control group conditions on these outcomes.
   Method: A literature search was conducted through four electronic databases from inception to February 2019. Considered for inclusion were randomized controlled trials (RCTs) investigating exercise interventions and depression or anxiety as outcomes in people living with HIV (>= 18 years of age). Ten studies were included (n = 479 participants, 49.67% females at baseline), and the standardized mean difference (SMD) and heterogeneity were calculated using random-effect models. An additional pre-post meta-analysis was also conducted.
   Results: A large effect in favor of exercise when compared to controls was found for depression (SMD = -0.84, 95%CI = [-1.57, -0.11], p = 0.02) and anxiety (SMD = -1.23, 95%CI = [-2.42, 0.04], p = -0.04). Subgroup analyses for depression revealed large effects on depression for aerobic exercise only (SMD = -0.96, 95%CI = [-1.63, -0.30], p = 0.004), a frequency of >= 3 exercise sessions per week (SMD = -1.39, 95%CI = [-2.24, -0.54], p < 0.001), professionally supervised exercise (SMD = -1.40, 95%CI = [-2.46, -0.17], p = 0.03]), and high-quality studies (SMD = -1.31, 95%CI = [-2.46, -0.17], p = 0.02).
   Conclusion: Exercise seems to decrease depressive symptoms and anxiety in PLWH, but other larger and high-quality studies are needed to verify these effects.
C1 [Heissel, Andreas; Zech, Philipp; Rapp, Michael A.; Lawrence, Jimmy B.] Univ Potsdam, Dept Exercise & Hlth Sci, Social & Prevent Med, Neuen Palais 10, D-14469 Potsdam, Germany.
   [Schuch, Felipe B.] Univ Fed Santa Maria, Dept Metodos & Tecn Desport, Santa Maria, RS, Brazil.
   [Kangas, Maria] Macquarie Univ, Dept Psychol, Ctr Emot Hlth, Sydney, NSW, Australia.
   [Heinzel, Stephan] Free Univ Berlin, Dept Educ & Psychol, Clin Psychol & Psychotherapy, Berlin, Germany.
C3 University of Potsdam; Universidade Federal de Santa Maria (UFSM);
   Macquarie University; Free University of Berlin
RP Heissel, A (corresponding author), Univ Potsdam, Dept Exercise & Hlth Sci, Social & Prevent Med, Neuen Palais 10, D-14469 Potsdam, Germany.
EM andreas.heissel@uni-potsdam.de
RI Schuch, Felipe/AAF-5028-2019; Heissel, Andreas/AAE-5643-2020; Rapp,
   Michael/ABB-7573-2020; Schuch, Felipe/L-4620-2016
OI Schuch, Felipe/0000-0002-5190-4515; Kangas, Maria/0000-0001-8693-2949;
   Rapp, Michael/0000-0003-0106-966X; Heissel, Andreas/0000-0001-9270-7027
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NR 87
TC 49
Z9 51
U1 0
U2 21
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-3999
EI 1879-1360
J9 J PSYCHOSOM RES
JI J. Psychosomat. Res.
PD NOV
PY 2019
VL 126
AR 109823
DI 10.1016/j.jpsychores.2019.109823
PG 12
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA JP5LD
UT WOS:000498305100002
PM 31518734
DA 2025-06-11
ER

PT S
AU Weiss, R
   Bremer, AA
   Lustig, RH
AF Weiss, Ram
   Bremer, Andrew A.
   Lustig, Robert H.
BE Powers, AC
   Ahima, RS
TI What is metabolic syndrome, and why are children getting it?
SO YEAR IN DIABETES AND OBESITY
SE Annals of the New York Academy of Sciences
LA English
DT Article
DE metabolic syndrome; obesity; diet; insulin resistance; reactive oxygen
   species
ID C-REACTIVE PROTEIN; ENDOPLASMIC-RETICULUM STRESS; TYPE-2
   DIABETES-MELLITUS; BODY-MASS INDEX; MAGNETIC-RESONANCE-SPECTROSCOPY;
   NUTRITION EXAMINATION SURVEY; CARDIOVASCULAR RISK-FACTORS;
   INSULIN-RESISTANCE SYNDROME; IMPAIRED GLUCOSE-TOLERANCE;
   CORONARY-HEART-DISEASE
AB Metabolic syndrome comprises a cluster of cardiovascular risk factors (hypertension, altered glucose metabolism, dyslipidemia, and abdominal obesity) that occur in obese children. However, metabolic syndrome can also occur in lean individuals, suggesting that obesity is a marker for the syndrome, not a cause. Metabolic syndrome is difficult to define, due to its nonuniform classification and reliance on hard cutoffs in the evaluation of disorders with non-Gaussian distributions. Defining the syndrome is even more difficult in children, owing to racial and pubertal differences and lack of cardiovascular events. Lipid partitioning among specific fat depots is associated with insulin resistance, which can lead to mitochondrial overload and dysfunctional subcellular energy use and drive the various elements of metabolic syndrome. Multiple environmental factors, in particular a typical Western diet, drive mitochondrial overload, while other changes in Western society, such as stress and sleep deprivation, increase insulin resistance and the propensity for food intake. These culminate in an adverse biochemical phenotype, including development of altered glucose metabolism and early atherogenesis during childhood and early adulthood.
C1 [Weiss, Ram] Hadassah Hebrew Univ, Sch Med, Dept Pediat, Jerusalem, Israel.
   [Bremer, Andrew A.] Vanderbilt Univ, Sch Med, Dept Pediat, Nashville, TN 37212 USA.
   [Lustig, Robert H.] Univ Calif San Francisco, Dept Pediat, San Francisco, CA 94143 USA.
   [Lustig, Robert H.] Univ Calif San Francisco, Philip R Lee Inst Hlth Policy Studies, San Francisco, CA 94143 USA.
C3 Hebrew University of Jerusalem; Hadassah University Medical Center;
   Vanderbilt University; University of California System; University of
   California San Francisco; University of California System; University of
   California San Francisco
RP Lustig, RH (corresponding author), Univ Calif San Francisco, Div Pediat Endocrinol, Box 0434,513 Parnassus Ave, San Francisco, CA 94143 USA.
EM rlustig@peds.ucsf.edu
RI Lustig, Robert/O-9380-2019; Weiss, Ram/AAC-3964-2020
FU National Institute of Diabetes and Digestive and Kidney Diseases
   [T32DK007161] Funding Source: NIH RePORTER
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NR 183
TC 224
Z9 255
U1 0
U2 33
PU BLACKWELL SCIENCE PUBL
PI OXFORD
PA OSNEY MEAD, OXFORD OX2 0EL, ENGLAND
SN 0077-8923
BN 978-1-57331-882-2
J9 ANN NY ACAD SCI
JI Ann.NY Acad.Sci.
PY 2013
VL 1281
BP 123
EP 140
DI 10.1111/nyas.12030
PG 18
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA BHL80
UT WOS:000325808500008
PM 23356701
OA Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Repke, HE
   Gulley, LD
   Rice, AJ
   Gallagher-Teske, JH
   Markos, B
   Sanchez, N
   Bristol, M
   Haynes, H
   Lavender, JM
   Neyland, MKH
   Shank, LM
   Emerick, JE
   Gutierrez-Colina, AM
   Arnold, T
   Thomas, V
   Haigney, MC
   Shomaker, LB
   Tanofsky-Kraff, M
AF Repke, Hannah E.
   Gulley, Lauren D.
   Rice, Alexander J.
   Gallagher-Teske, Julia H.
   Markos, Bethelhem
   Sanchez, Natalia
   Bristol, Madison
   Haynes, Hannah
   Lavender, Jason M.
   Neyland, Mary K. Higgins
   Shank, Lisa M.
   Emerick, Jill E.
   Gutierrez-Colina, Ana M.
   Arnold, Thomas
   Thomas, Victoria
   Haigney, Mark C.
   Shomaker, Lauren B.
   Tanofsky-Kraff, Marian
TI Addressing Anxiety and Stress for Healthier Eating in Teens (ASSET): A
   Pilot Randomized Controlled Trial Protocol for Reducing Anxiety,
   Disinhibited Eating, Excess Weight Gain, and Cardiometabolic Risk in
   Adolescent Girls
SO NUTRIENTS
LA English
DT Article
DE anxiety; interpersonal psychotherapy; cognitive behavioral therapy;
   disinhibited eating; excess weight gain prevention; cardiometabolic risk
ID COGNITIVE-BEHAVIORAL THERAPY; PSYCHOLOGICAL TREATMENTS; METABOLIC
   SYNDROME; INTERPERSONAL PSYCHOTHERAPY; CHILDHOOD OVERWEIGHT;
   SOCIAL-ADJUSTMENT; PEDIATRIC LOSS; FOLLOW-UP; CHILDREN; BINGE
AB (1) Background: Standard-of-care lifestyle interventions show insufficient effectiveness for the prevention and treatment of excess weight and its associated cardiometabolic health concerns in adolescents, necessitating more targeted preventative approaches. Anxiety symptoms are common among adolescents, especially girls at risk for excess weight gain, and have been implicated in the onset and maintenance of disinhibited eating. Thus, decreasing elevated anxiety in this subset of adolescent girls may offer a targeted approach to mitigating disinhibited eating and excess weight gain to prevent future cardiometabolic health problems. (2) Methods: The current paper describes the protocol for a multisite pilot and feasibility randomized controlled trial of group cognitive behavioral therapy (CBT) and group interpersonal psychotherapy (IPT) in N = 40 adolescent girls (age 12-17 years) with elevated anxiety symptoms and body mass index (BMI; kg/m(2)) >= 75th percentile for age/sex. (3) Results: Primary outcomes are multisite feasibility of recruitment, protocol procedures, and data collection, intervention fidelity, retention at follow-ups, and acceptability of interventions and study participation. (4) Conclusions: Findings will inform the protocol for a future fully-powered multisite randomized controlled trial to compare CBT and IPT efficacy for reducing excess weight gain and preventing adverse cardiometabolic trajectories, as well as to evaluate theoretically-informed treatment moderators and mediators.
C1 [Repke, Hannah E.; Rice, Alexander J.; Gallagher-Teske, Julia H.; Markos, Bethelhem; Haynes, Hannah; Lavender, Jason M.; Neyland, Mary K. Higgins; Shank, Lisa M.; Arnold, Thomas; Thomas, Victoria; Haigney, Mark C.; Tanofsky-Kraff, Marian] Uniformed Serv Univ Hlth Sci, Dept Med, Mil Cardiovasc Outcomes Res MiCOR Program, Bethesda, MD 20814 USA.
   [Repke, Hannah E.; Markos, Bethelhem; Arnold, Thomas; Thomas, Victoria] Metis Fdn, San Antonio, TX 78216 USA.
   [Gulley, Lauren D.; Sanchez, Natalia; Bristol, Madison; Gutierrez-Colina, Ana M.; Shomaker, Lauren B.] Colorado State Univ, Dept Human Dev & Family Studies, Ft Collins, CO 80523 USA.
   [Gulley, Lauren D.; Gutierrez-Colina, Ana M.; Shomaker, Lauren B.] Univ Colorado, Dept Pediat, Sect Endocrinol, Anschutz & Childrens Hosp Colorado, Aurora, CO 80045 USA.
   [Bristol, Madison] Colorado Sch Publ Hlth, Aurora, CO 80045 USA.
   [Shank, Lisa M.; Shomaker, Lauren B.; Tanofsky-Kraff, Marian] Uniformed Serv Univ Hlth Sci, Dept Med & Clin Psychol, Bethesda, MD 20814 USA.
   [Emerick, Jill E.] Uniformed Serv Univ Hlth Sci, Dept Pediat, Bethesda, MD 20814 USA.
C3 Uniformed Services University of the Health Sciences - USA; Colorado
   State University System; Colorado State University Fort Collins;
   University of Colorado System; University of Colorado Anschutz Medical
   Campus; Colorado School of Public Health; Uniformed Services University
   of the Health Sciences - USA; Uniformed Services University of the
   Health Sciences - USA
RP Tanofsky-Kraff, M (corresponding author), Uniformed Serv Univ Hlth Sci, Dept Med, Mil Cardiovasc Outcomes Res MiCOR Program, Bethesda, MD 20814 USA.; Tanofsky-Kraff, M (corresponding author), Uniformed Serv Univ Hlth Sci, Dept Med & Clin Psychol, Bethesda, MD 20814 USA.
EM marian.tanofsky-kraff@usuhs.edu
RI Sanchez, Natalia/KGL-7474-2024; Shank, Lisa/I-7079-2015
OI Haigney, Mark/0000-0001-6449-4386; Tanofsky-Kraff,
   Marian/0000-0003-3871-2233; Shomaker, Lauren/0000-0002-6129-8707;
   Sanchez, Natalia/0000-0001-7929-4029; Arnold,
   Thomas/0009-0003-9665-4518; Shank, Lisa/0000-0002-6922-7946; Rice,
   Alexander/0009-0003-9902-807X
FU  [HU00011920029]
FX This researchwas funded by theDefenseHealthAgency (DHA), grant number
   HU00011920029.
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NR 117
TC 2
Z9 2
U1 1
U2 4
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD OCT
PY 2022
VL 14
IS 20
AR 4246
DI 10.3390/nu14204246
PG 20
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 5R2XW
UT WOS:000874379500001
PM 36296930
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Ramos, VL
   Van Voorhees, AS
AF Ramos, Vanessa L.
   Van Voorhees, Abby S.
TI Guidelines for Management of Psoriasis Screening for
   Comorbidities
SO JOURNAL OF THE DERMATOLOGY NURSES ASSOCIATION
LA English
DT Article
DE Guidelines; Psoriasis; Comorbidities; Metabolic Syndrome; Cardiovascular
   Disease; Inflammatory Bowel Disease; Nonalcoholic Fatty Liver Disease;
   Mental Health; Depression; Malignancy; Renal Disease; Chronic
   Obstructive Pulmonary Disease; Obstructive Sleep Apnea; Uveitis
ID METABOLIC SYNDROME; KIDNEY-DISEASE; ARTHRITIS; RISK; PREVALENCE; THERAPY
AB Psoriasis is a common, inflammatory disease that can significantly impact patients' quality of life and well-being. In recent years, psoriasis has been found to be associated with several comorbidities including psoriatic arthritis, cardiovascular disease, metabolic conditions, mental health disorders, and other inflammatory disorders. This article reviews current literature about emerging comorbidities and provides screening recommendations based on available evidence in an effort to improve the overall management of psoriatic patients.
C1 [Ramos, Vanessa L.; Van Voorhees, Abby S.] Eastern Virginia Med Sch, Dept Dermatol, Norfolk, VA 23507 USA.
C3 Eastern Virginia Medical School
RP Ramos, VL (corresponding author), Eastern Virginia Med Sch, 721 Fairfax Ave,Suite 200, Norfolk, VA 23507 USA.
EM ramosvl@evms.edu
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NR 58
TC 1
Z9 1
U1 1
U2 3
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1945-760X
EI 1945-7618
J9 J DERMAT NURSES ASSO
JI J. DERMAT. NURSES ASSOC.
PD MAY-JUN
PY 2021
VL 13
IS 3
BP 168
EP 174
DI 10.1097/JDN.0000000000000618
PG 7
WC Dermatology
WE Emerging Sources Citation Index (ESCI)
SC Dermatology
GA SF9EG
UT WOS:000653049100004
DA 2025-06-11
ER

PT J
AU Chang, YC
   Vitale, E
AF Chang, Yun-Chen
   Vitale, Elsa
TI Body mass index conditions and eating attitudes in young nurses: a pilot
   psycho-immune-endocrine investigation
SO ITALIAN JOURNAL OF MEDICINE
LA English
DT Article
DE anxiety; depression; eating habit; inflammation; insomnia; nurse; stress
ID INSOMNIA SEVERITY INDEX; C-REACTIVE PROTEIN; SHIFT WORK; SLEEP DURATION;
   METABOLIC SYNDROME; COLORECTAL-CANCER; CIGARETTE-SMOKING; HOSPITAL
   NURSES; STRESS-RESPONSE; ITALIAN NURSES
AB Purpose. To investigate a cohort of young Italian nurses to identify whether the body mass index (BMI) and eating flexibility differed and were associated according to the basic characteristics of sex, smoking behavior, or shift activity, the levels of neutrophils, lymphocytes, or platelets in blood, and the psychological conditions of anxiety, depression, stress, or insomnia. Materials and Methods. The data include sex, BMI, smoking behavior, shift activity, neutrophil, lymphocyte, and platelet levels, eating flexibility [measured using the eating disorder flexibility index (EDFLIX) and the subdimensions EDFLIX-GF for general flexibility, EDFLIX-FoEx for food and exercise flexibility, and EDFLIX-WeSh for weight and shape flexibility], and mental health [assessed using the depression, anxiety, and stress scale (DASS-21) and the insomnia severity index (ISI)]. Results. Differences in BMI with shift work (P=0.042) and anxiety with total EDFLIX (P<0.001), EDFLIX-GF (P<0.001), and EDFLIX-WeSh (P=0.044) scores were significant. Having depression was associated with significant differences in total EDFLIX (P<0.001), EDFLIX-GF (P=0.005), and EDFLIX-WeSh (P<0.001) scores. Nurses with moderate stress reported high total EDFLIX (P<0.001), EDGLIX-FoEx (P<0.001), and EDFLIX-WeSh (P=0.013) scores. Nurses with mild stress reported high EDFLIX-GF scores (P<0.001). Nurses without insomnia symptoms reported significantly high EDFLIX-FoEx scores (P<0.001). Associations between lymphocyte levels and EDFLIX-FoEx (beta=-0.264; P=0.003), stress and EDFLIX-total (beta=-0.436; P<0.001), EDFLIX-GF (beta=-0.466; P<0.001) and EDFLIX-WeSh (P=0.022), and also between insomnia and EDFLIX-FoEx (beta=-0.245; P<0.001) were significant. Conclusions. Nurses, from the beginning of their careers, should be monitored and encouraged to avoid adverse health practices that negatively influence their quality of life.
C1 [Chang, Yun-Chen] China Med Univ, Sch Nursing, Taichung, Taiwan.
   [Chang, Yun-Chen] China Med Univ, Grad Inst Nursing, Taichung, Taiwan.
   [Chang, Yun-Chen] China Med Univ, Nursing Dept, Taichung, Taiwan.
   [Vitale, Elsa] Local Healthcare Author, Ctr Mental Hlth Modugno, Bari, Italy.
C3 China Medical University Taiwan; China Medical University Taiwan; China
   Medical University Taiwan
RP Vitale, E (corresponding author), Local Healthcare Author Bari, Dept Mental Hlth, Via X Marzo 43, I-70026 Bari, Italy.
EM vitaleelsa@libero.it
RI Vitale, Elsa/D-8904-2018; Wang, Pa-Chun/AAD-4094-2019
OI Chang, Yun-Chen/0000-0001-7099-6016; Vitale, Elsa/0000-0002-9738-3479
FU Taiwan Nurses Association [TWNA-1121006]
FX this research was partially supported by a grant from Taiwan Nurses
   Association (No. TWNA-1121006), received by YCC. The funder had no role
   in study design, data collection, analysis, decision to publish, or
   preparation of the manuscript.
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NR 143
TC 0
Z9 0
U1 1
U2 2
PU PAGEPRESS PUBL
PI PAVIA
PA MEDITGROUP, VIA G BELLI, 4, PAVIA, 27100, ITALY
SN 1877-9344
EI 1877-9352
J9 ITAL J MED
JI Ital. J. Med.
PY 2023
VL 17
IS 3
AR 1654
DI 10.4081/itjm.2023.1654
PG 13
WC Medicine, General & Internal
WE Emerging Sources Citation Index (ESCI)
SC General & Internal Medicine
GA U8BP6
UT WOS:001087004200003
OA gold
DA 2025-06-11
ER

PT J
AU Marzoog, B
AF Marzoog, Basheer
TI Lipid Behavior in Metabolic Syndrome Pathophysiology
SO CURRENT DIABETES REVIEWS
LA English
DT Review
DE Pathogenesis; adaptation; metabolic syndrome; insulin resistance; lipid;
   homeostasis; diabetes mellitus; hypertension; cardiovascular
ID CHAIN FATTY-ACIDS; INSULIN-RESISTANCE; ADIPOSE-TISSUE; INFLAMMATION;
   OMEGA-3-FATTY-ACIDS; MITOCHONDRIA; RECEPTORS; PLASMALOGENS; MEMBRANES;
   DISEASE
AB Undeniably, lipid plays an extremely important role in the homeostasis balance since lipid contributes to the regulation of the metabolic processes. The metabolic syndrome pathogenesis is multi-pathway that composes neurohormonal disorders, endothelial cell dysfunction, metabolic disturbance, genetic predisposition, in addition to gut commensal microbiota. The heterogenicity of the possible mechanisms gives the metabolic syndrome its complexity and limitation of therapeutic accesses. The main pathological link is that lipid contributes to the emergence of metabolic syndrome via central obesity and visceral obesity that consequently lead to oxidative stress and chronic inflammatory response promotion. Physiologically, a balance is kept between the adiponectin and adipokines levels to maintain the lipid level in the organism. Clinically, extremely important to define the borders of the lipid level in which the pathogenesis of the metabolic syndrome is reversible, otherwise it will be accompanied by irreversible complications and sequelae of the metabolic syndrome (cardiovascular, insulin resistance). The present paper is dedicated to providing novel insights into the role of lipid in the development of metabolic syndrome; hence dyslipidemia is the initiator of insulin resistance syndrome (metabolic syndrome).
C1 [Marzoog, Basheer] Natl Res Mordovia State Univ, Dept Med Sch Student, Mordovia, Russia.
RP Marzoog, B (corresponding author), Natl Res Mordovia State Univ, Dept Med Sch Student, Mordovia, Russia.
EM marzug@mail.ru
RI Marzoog, Basheer Abdullah/AAD-6284-2021
OI Marzoog, Basheer Abdullah/0000-0001-5507-2413
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NR 73
TC 11
Z9 16
U1 2
U2 20
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1573-3998
EI 1875-6417
J9 CURR DIABETES REV
JI Curr. Diabetes Reviews
PY 2022
VL 18
IS 6
AR e150921196497
DI 10.2174/1573399817666210915101321
PG 8
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA 2U7BW
UT WOS:000823312600004
PM 34525924
DA 2025-06-11
ER

PT J
AU Zadeh, MM
   Dehghan, P
   Eslami, Z
AF Zadeh, Mehdi Mohammadi
   Dehghan, Parvin
   Eslami, Zahra
TI Effect of date seed (Phoenix dactylifera) supplementation as
   functional food on cardiometabolic risk factors, metabolic endotoxaemia
   and mental health in patients with type 2 diabetes mellitus: a blinded
   randomised controlled trial protocol
SO BMJ OPEN
LA English
DT Article
DE DIABETES & ENDOCRINOLOGY; Nutrition; Health informatics
ID OXIDATIVE STRESS; INSULIN-RESISTANCE; MANAGEMENT; ANTIOXIDANT;
   POLYPHENOLS; MECHANISMS; EXERCISE; EXTRACT; HERBS
AB Introduction Recently, the improvement of chronic hyperglycaemia-related damage of type 2 diabetes mellitus (T2DM) through functional food consumption has attracted the attention of many clinicians. This study aims to determine the effectiveness of date seed powder (DSP) as a functional food (prebiotic) on the cardiometabolic risk factors, oxidative stress, anti-/inflammatory biomarkers, metabolic endotoxaemia (gut microbiota), adipokines, hypothalamic-pituitary-adrenal axis biomarkers, immune system, anthropometric indices and mental health in patients with T2DM.
   Methods This study protocol will be conducted as randomised, triple-blind, placebo-controlled trial with the inclusion of 48 patients with T2DM. The participants will be randomly assigned into two equal groups of intervention (n=24) and placebo (n=24) and receive 5g/day of DSP or placebo for 8weeks, respectively. At baseline and post-intervention, fasting blood samples will be collected to assess the serum levels of lipid profile, glycaemic indices, antioxidant and oxidative stress, anti-/inflammatory biomarkers, lipopolysaccharide, 8-hydroxy-guanine, adipokines, hypothalamic-pituitary-adrenal axis biomarkers, immune system and mental health. Data will be analysed using the SPSS software (V.16.0). To compare the quantitative variables, paired and unpaired Student's t-tests and covariance analyses will be used.
   Discussion In this study, the potential effects of DSP on patients with T2DM will be evaluated for the first time. It is hoped that the results would increase the body of scientific knowledge about DSP supplementation on the cardiometabolic risk factors, oxidative stress, anti-/inflammatory biomarkers, metabolic endotoxaemia, adipokines, hypothalamic-pituitary-adrenal axis biomarkers, immune system, anthropometric indices and mental health in patients with T2DM.Ethics and disseminationThe study protocol was approved by the Ethical Committee of the Tabriz University of Medical Sciences, Tabriz, Iran (code: IR.TBZMED.REC.1400.752).
C1 [Zadeh, Mehdi Mohammadi] Tabriz Univ Med Sci, Fac Nutr & Food Sci, Student Res Comm, Tabriz, Iran.
   [Dehghan, Parvin] Tabriz Univ Med Sci, Fac Nutr & Food Sci, Nutr Res Ctr, Dept Biochem & Diet Therapy, Tabriz, Iran.
   [Eslami, Zahra] Kerman Univ Med Sci, Dept Nutr, Kerman, Iran.
C3 Tabriz University of Medical Science; Tabriz University of Medical
   Science; Kerman University of Medical Sciences
RP Dehghan, P (corresponding author), Tabriz Univ Med Sci, Fac Nutr & Food Sci, Nutr Res Ctr, Dept Biochem & Diet Therapy, Tabriz, Iran.
EM dehghan.nut@gmail.com
RI Dehghan, Parvin/G-3885-2015
OI Dehghan, Parvin/0000-0001-8929-3302
FU Tabriz University of Medical Science [68035]
FX The Tabriz University of Medical Science supported this trial as part of
   a government--backed project (grant number: 68035).
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NR 60
TC 3
Z9 3
U1 1
U2 9
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2044-6055
J9 BMJ OPEN
JI BMJ Open
PD FEB
PY 2023
VL 13
IS 3
AR e066013
DI 10.1136/bmjopen-2022-066013
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA G8ZO7
UT WOS:000991974800039
PM 36931666
OA gold, Green Published
DA 2025-06-11
ER

PT S
AU Phillips, DIW
   Jones, A
   Goulden, PA
AF Phillips, David I. W.
   Jones, Alexander
   Goulden, Peter A.
BE Chrousos, GP
   Tsigos, C
TI Birth weight, stress, and the metabolic syndrome in adult life
SO STRESS, OBESITY, AND METABOLIC SYNDROME
SE Annals of the New York Academy of Sciences
LA English
DT Article; Proceedings Paper
CT Bjorntorp Symposium on Stress, Obesity, and Metabolic Syndrome
CY APR 09-10, 2005
CL Athens, GREECE
SP Roche Hellas, Abbott Hellas, Pfizer Hellas, Sanofi Aventis Hellas, GlaxoSmithKline Hellas
DE birth weight; metabolic syndrome; hormonal systems
ID INSULIN-RESISTANCE SYNDROME; CARDIOVASCULAR RISK-FACTORS;
   LEFT-VENTRICULAR MASS; BLOOD-PRESSURE; GLUCOSE-TOLERANCE; ABDOMINAL
   OBESITY; GROWTH; MEN; REACTIVITY; CORTISOL
AB There is now widespread agreement that small size at birth is associated with an increased risk of the metabolic syndrome (glucose intolerance, high blood pressure, and dyslipidemia) and related pathologies, including cardiovascular disease in later life. Evidence is emerging that suggests that programming of hormonal systems in response to an adverse fetal environment may be one of the mechanisms underlying these long-term consequences of growth restriction in early life. In particular, alterations in neuroendocrine responses to stress may be important. Recent research suggests that increased adrenocortical and sympatho-adrenal responses are associated with small size at birth. Epidemiological studies show that such physiological alterations in these neuroendocrine systems may have potent effects on risk of cardiovascular disease through their influence on risk factors, such as plasma glucose and lipid concentrations and blood pressure.
C1 Univ Southampton, Dev Origins Hlth & Dis Div, Southampton SO16 6YD, Hants, England.
C3 University of Southampton
RP Phillips, DIW (corresponding author), Univ Southampton, Dev Origins Hlth & Dis Div, Level F,Southampton Gen Hosp,Tremona Rd, Southampton SO16 6YD, Hants, England.
EM diwp@mrc.soton.ac.uk
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NR 41
TC 52
Z9 59
U1 0
U2 1
PU BLACKWELL SCIENCE PUBL
PI OXFORD
PA OSNEY MEAD, OXFORD OX2 0EL, ENGLAND
SN 0077-8923
BN 978-1-57331-625-5
J9 ANN NY ACAD SCI
JI Ann.NY Acad.Sci.
PY 2006
VL 1083
BP 28
EP 36
DI 10.1196/annals.1367.027
PG 9
WC Endocrinology & Metabolism; Multidisciplinary Sciences
WE Conference Proceedings Citation Index - Science (CPCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Science & Technology - Other Topics
GA BFR90
UT WOS:000244102900004
PM 17148731
DA 2025-06-11
ER

PT J
AU Thomson, EM
AF Thomson, Errol M.
TI Air Pollution, Stress, and Allostatic Load: Linking Systemic and Central
   Nervous System Impacts
SO JOURNAL OF ALZHEIMERS DISEASE
LA English
DT Review
DE Air pollution; brain; cognition; dementia; depression;
   hypothalamic-pituitary-adrenal (HPA) axis; mental health; ozone;
   particulate matter
ID PARTICULATE MATTER EXPOSURE; INSULIN-DEGRADING ENZYME; COGNITIVE
   FUNCTION; OZONE EXPOSURE; METABOLIC SYNDROME; HPA AXIS; MITOCHONDRIAL
   DYSFUNCTION; GLUCOCORTICOIDS MEDIATE; NONCHEMICAL STRESSORS; HIPPOCAMPAL
   ATROPHY
AB Air pollution is a risk factor for cardiovascular and respiratory morbidity and mortality. A growing literature also links exposure to diverse air pollutants (e.g., nanoparticles, particulate matter, ozone, traffic-related air pollution) with brain health, including increased incidence of neurological and psychiatric disorders such as cognitive decline, dementia (including Alzheimer's disease), anxiety, depression, and suicide. A critical gap in our understanding of adverse impacts of pollutants on the central nervous system (CNS) is the early initiating events triggered by pollutant inhalation that contribute to disease progression. Recent experimental evidence has shown that particulate matter and ozone, two common pollutants with differing characteristics and reactivity, can activate the hypothalamic-pituitary-adrenal (HPA) axis and release glucocorticoid stress hormones (cortisol in humans, corticosterone in rodents) as part of a neuroendocrine stress response. The brain is highly sensitive to stress: stress hormones affect cognition and mental health, and chronic stress can produce profound biochemical and structural changes in the brain. Chronic activation and/or dysfunction of the HPA axis also increases the burden on physiological stress response systems, conceptualized as allostatic load, and is a common pathway implicated in many diseases. The present paper provides an overview of how systemic stress-dependent biological responses common to particulate matter and ozone may provide insight into early CNS effects of pollutants, including links with oxidative, inflammatory, and metabolic processes. Evidence of pollutant effect modification by non-chemical stressors (e.g., socioeconomic position, psychosocial, noise), age (prenatal to elderly), and sex will also be reviewed in the context of susceptibility across the lifespan.
C1 [Thomson, Errol M.] Hlth Canada, Hlth Environm & Consumer Safety Branch, Environm Hlth Sci & Res Bur, Ottawa, ON, Canada.
C3 Health Canada
RP Thomson, EM (corresponding author), Hlth Canada, Inhalat Toxicol Lab, Hazard Identificat Div, Environm Hlth Sci & Res Bur, 0802B Tunneys Pasture, Ottawa, ON K1A 0K9, Canada.
EM errol.thomson@canada.ca
OI Thomson, Errol/0000-0003-1295-5384
FU Health Canada through the Clean Air Regulatory Agenda
FX The author is grateful for the contributions of collaborators,
   postdoctoral fellows, and students to the studies that formed the basis
   of this paper. Thanks to Drs. Dalibor Breznan, Guillaume Pelletier, and
   Jith Thomas for their helpful comments on the manuscript. Thanks also to
   the anonymous peer-reviewers, whose generous and constructive comments
   helped improve this paper. The research projects that led to this work
   were funded by Health Canada through the Clean Air Regulatory Agenda.
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NR 154
TC 170
Z9 184
U1 0
U2 76
PU IOS PRESS
PI AMSTERDAM
PA NIEUWE HEMWEG 6B, 1013 BG AMSTERDAM, NETHERLANDS
SN 1387-2877
EI 1875-8908
J9 J ALZHEIMERS DIS
JI J. Alzheimers Dis.
PY 2019
VL 69
IS 3
BP 597
EP 614
DI 10.3233/JAD-190015
PG 18
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA ID6IN
UT WOS:000471781600001
PM 31127781
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Khazdouz, M
   Djalalinia, S
   Zadeh, SS
   Hasani, M
   Shidfar, F
   Ataie-Jafari, A
   Asayesh, H
   Zarei, M
   Gorabi, AM
   Noroozi, M
   Qorbani, M
AF Khazdouz, Maryam
   Djalalinia, Shirin
   Zadeh, Sara Sarrafi
   Hasani, Motahareh
   Shidfar, Farzad
   Ataie-Jafari, Asal
   Asayesh, Hamid
   Zarei, Maryam
   Gorabi, Armita Mahdavi
   Noroozi, Mehdi
   Qorbani, Mostafa
TI Effects of Zinc Supplementation on Cardiometabolic Risk Factors: a
   Systematic Review and Meta-analysis of Randomized Controlled Trials
SO BIOLOGICAL TRACE ELEMENT RESEARCH
LA English
DT Review
DE Metabolic syndrome; Cardiometabolic risk factors; Zinc supplementation;
   Meta-analysis; Systematic review
ID ARTERIAL-BLOOD PRESSURE; INSULIN-RESISTANCE; DOUBLE-BLIND; METABOLIC
   SYNDROME; GLYCEMIC CONTROL; OXIDATIVE STRESS; GLUCOSE; DEFICIENCY;
   PREVALENCE; ADOLESCENTS
AB The prevalence of cardiometabolic risk factors has been increasing worldwide. The results of reported studies on the effects of zinc supplementation on cardiometabolic risk factors are unequivocal. This systematic review and meta-analysis of randomized controlled trials was conducted to evaluate the effects of zinc supplementation on cardiometabolic risk factors. A systematic search was conducted through international databases (PubMed/Medline, Institute of Scientific Information, and Scopus) until December 2018 to include all randomized controlled trials (RCT), quasi-RCT, and controlled clinical trials which assessed the effect of zinc supplementation on cardiometabolic risk factors including lipid profile, glycemic indices, blood pressure, and anthropometric indices. Random- or fixed-effects meta-analysis method was used to estimate the standardized mean difference (SMD) and 95% confidence interval (CI). A total of 20 studies were included in the meta-analysis, which included a total of 1141 participants in the intervention group. Meta-analysis showed that zinc supplementation significantly decreased plasma levels of triglyceride (SMD - 0.66, 95% CI - 1.27, - 0.06), very-low-density lipoprotein (SMD - 1.59, 95% CI - 2.86, - 0.31), and total cholesterol (SMD - 0.65, 95% CI - 1.15, - 0.15). Similarly, zinc supplementation significantly decreased fasting blood glucose (SMD - 0.52, 95% CI - 0.96, - 0.07) and HbA1c (SMD - 0.64, 95% CI - 1.27, - 0.02). The effects of zinc supplementation on blood pressure and anthropometric indices were not statistically significant (P > 0.05). Zinc supplements had beneficial effects on glycemic indices and lipid profile. Thus, it appeared that zinc supplementation might be associated with a decrease in cardiometabolic risk factors contributing to a reduction in risk of atherosclerosis.
C1 [Khazdouz, Maryam; Hasani, Motahareh; Shidfar, Farzad] Iran Univ Med Sci, Sch Publ Hlth, Tehran, Iran.
   [Djalalinia, Shirin] Minist Hlth & Med Educ, Dev Res & Technol Ctr, Res & Technol, Tehran, Iran.
   [Djalalinia, Shirin] Univ Tehran Med Sci, Noncommunicable Dis Res Ctr, Endocrinol & Metab Populat Sci Inst, Tehran, Iran.
   [Zadeh, Sara Sarrafi; Ataie-Jafari, Asal] Islamic Azad Univ, Sci & Res Branch, Dept Nutr, Tehran, Iran.
   [Asayesh, Hamid] Qom Univ Med Sci, Dept Med Emergencies, Qom, Iran.
   [Zarei, Maryam] Univ Putra Malaysia, Dept Nutr & Dietet, Fac Med & Hlth Sci, Serdang, Selangor, Malaysia.
   [Gorabi, Armita Mahdavi] Univ Tehran Med Sci, Dept Basic & Clin Res, Tehran Heart Ctr, Tehran, Iran.
   [Noroozi, Mehdi] Univ Social Welf & Rehabil Sci, Social Determinants Hlth Res Ctr, Tehran, Iran.
   [Qorbani, Mostafa] Alborz Univ Med Sci, Noncommunicable Dis Res Ctr, Karaj, Iran.
   [Qorbani, Mostafa] Univ Tehran Med Sci, Chron Dis Res Ctr, Endocrinol & Metab Populat Sci Inst, Tehran, Iran.
C3 Iran University of Medical Sciences; Ministry of Health & Medical
   Education (MOHME); Tehran University of Medical Sciences; Islamic Azad
   University; Universiti Putra Malaysia; Tehran University of Medical
   Sciences; Alborz University of Medical Sciences; Tehran University of
   Medical Sciences
RP Qorbani, M (corresponding author), Alborz Univ Med Sci, Noncommunicable Dis Res Ctr, Karaj, Iran.; Qorbani, M (corresponding author), Univ Tehran Med Sci, Chron Dis Res Ctr, Endocrinol & Metab Populat Sci Inst, Tehran, Iran.
EM qorbani13@yahoo.com
RI Qorbani, Mostafa/M-8171-2017; Zarei, Maryam/JUF-6439-2023; khazdouz,
   maryam/AAB-3490-2021; Demissie, Dereje/AAN-3556-2021; Shidfar,
   Farzad/H-6651-2018; noroozi, mehdi/L-5762-2017; Hasani,
   Motahareh/AAY-8608-2020
OI hasani, motahareh/0000-0002-9002-1192
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NR 87
TC 22
Z9 24
U1 0
U2 10
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0163-4984
EI 1559-0720
J9 BIOL TRACE ELEM RES
JI Biol. Trace Elem. Res.
PD JUN
PY 2020
VL 195
IS 2
BP 373
EP 398
DI 10.1007/s12011-019-01870-9
PG 26
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA LG2QR
UT WOS:000527952400003
PM 31494808
DA 2025-06-11
ER

PT J
AU Shimabukuro, M
AF Shimabukuro, Michio
TI Cardiac Adiposity and Global Cardiometabolic Risk - New Concept and
   Clinical Implication
SO CIRCULATION JOURNAL
LA English
DT Review
DE Coronary heart disease; Diabetes mellitus; Endothelial function; Fatty
   acids; Obesity
ID METABOLIC SYNDROME; INSULIN-RESISTANCE; CARDIOVASCULAR-DISEASE;
   OXIDATIVE STRESS; HEART-DISEASE; MOLECULAR-MECHANISMS; WAIST
   CIRCUMFERENCE; ATRIAL-FIBRILLATION; ABDOMINAL OBESITY; VISCERAL OBESITY
AB The obesity epidemic is a global public health concern that increases the likelihood of morbidity and mortality of metabolic and cardiovascular disease (CVD), and threatens to reduce life expectancy around the world. The concept of the metabolic syndrome (MetS) takes into account the essential role that visceral fat plays in the development of metabolic and CVDs, and indicates how waist circumference measurement aids patient identification in the clinical setting. However, MetS cannot be used to assess global CVD risk and is, at best, another modifiable risk factor. Thus, the global cardiometabolic risk (ie, global risk of CVD resulting from traditional risk factors combined with the additional contribution of MetS) should be considered individually. The contribution Of abdominal obesity to global cardiometabolic risk is reviewed and also discussed are potential Underlying mechanisms including, adipocytokine, insulin resistance, lipotoxicity and ectopic fat deposition in the heart components: (1) circulatory and locally recruited fat, (2) intra- and extra-myocellular fat, (3) perivascular fat, and (4) pericardial fat.
C1 Univ Ryukyus, Fac Med, Dept Internal Med 2, Okinawa 9030215, Japan.
C3 University of the Ryukyus
RP Shimabukuro, M (corresponding author), Univ Ryukyus, Fac Med, Dept Internal Med 2, 207 Uehara, Okinawa 9030215, Japan.
EM mshimabukuro-ur@umin.ac.jp
FU Scientific Research from the Japanese Society for the Promotion of
   Science; Ministry, of Education, Culture, Sports, Science; Technology
   and Ministry of Health
FX This work was supported by Grants-in-Aid for Scientific Research from
   the Japanese Society for the Promotion of Science, the Ministry, of
   Education, Culture, Sports, Science and the Technology and Ministry of
   Health, Labour and we fire. The author sincerely thanks every
   collaborator, especially Drs Roger H. Unger, Chris B. Newgard, and J
   Dennis McGarry for their encouragement.
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NR 71
TC 82
Z9 85
U1 0
U2 5
PU JAPANESE CIRCULATION SOC
PI TOYKO
PA 18TH FLOOR IMPERIAL HOTEL TOWER, 1-1-1 UCHISAIWAI-CHO CHIYODA-KU, TOYKO,
   100-0011, JAPAN
SN 1346-9843
EI 1347-4820
J9 CIRC J
JI Circ. J.
PD JAN
PY 2009
VL 73
IS 1
BP 27
EP 34
DI 10.1253/circj.CJ-08-1012
PG 8
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 388ZI
UT WOS:000262058800005
PM 19057089
OA Bronze
DA 2025-06-11
ER

PT J
AU Bayrak, M
AF Bayrak, Muharrem
TI Metabolic syndrome, depression, and fibromyalgia syndrome prevalence in
   patients with irritable bowel syndrome A case-control study
SO MEDICINE
LA English
DT Article
DE anxiety; depression; insulin resistance; irritable bowel syndrome;
   metabolic syndrome; obesity
ID MICROBIOTA; ANXIETY
AB Although both metabolic syndrome (MetS) and irritable bowel syndrome (IBS) have been linked with altered gut microbiota, only a few studies investigated the association between them. Hence, we aimed to evaluate the prevalence of MetS along with depression and fibromyalgia syndrome (FMS) in IBS patients.
   This was a case-control study in which 3808 consecutive patients who attended outpatient clinics of Erzurum Regional Training and Research Hospital between May 2019 and August 2019 were evaluated in terms of IBS with Rome-IV criteria. Out of 486 patients who were diagnosed as IBS, 176 patients were excluded for various reasons. Control subjects were randomly selected from IBS-negative subjects. MetS was diagnosed based on International Diabetes Federation criteria. Depression, anxiety disorder, and FMS were assessed via Hamilton Depression Scale, Beck Anxiety Inventory, and American College of Rheumatology criteria, respectively. Blood samples were obtained to measure biochemical parameters.
   Study group included 310 IBS patients, and control group included 304 subjects. The prevalence of the MetS was significantly higher among IBS patients compared with controls (36.8% vs 21.7%, respectively, P=.006). The rate of obesity was 18.1% among IBS subjects, and 10.2% in the controls. The prevalence of fibromyalgia (30% vs 3%, respectively, P<.001), anxiety-disorder (39.7% vs 10.2%, P<.001) and depression (8.1% vs 4.9%, P<.001) were significantly higher in IBS group than controls.
   Metabolic syndrome and obesity were significantly more frequent in IBS patients compared with controls. FMS, anxiety disorder, and depression were also more common among IBS patients.
C1 [Bayrak, Muharrem] Univ Hlth Sci, Erzurum Reg Training & Res Hosp, Dept Internal Med, TR-25000 Erzurum, Turkey.
C3 Erzurum Bolge Training & Research Hospital; University of Health
   Sciences Turkey; Ataturk University
RP Bayrak, M (corresponding author), Univ Hlth Sci, Erzurum Reg Training & Res Hosp, Dept Internal Med, TR-25000 Erzurum, Turkey.
EM muhabayrak@hotmail.com
RI Tusconi, Massimo/M-9150-2013
OI Tusconi, Massimo/0000-0002-9155-4740
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NR 27
TC 16
Z9 16
U1 0
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD JUN
PY 2020
VL 99
IS 23
AR e20577
DI 10.1097/MD.0000000000020577
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA MM1BB
UT WOS:000549892300064
PM 32502027
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Hall, KS
   Morey, MC
   Beckham, JC
   Bosworth, HB
   Sloane, R
   Pieper, CF
   Pebole, MM
AF Hall, Katherine S.
   Morey, Miriam C.
   Beckham, Jean C.
   Bosworth, Hayden B.
   Sloane, Richard
   Pieper, Carl F.
   Pebole, Michelle M.
TI Warrior Wellness: A Randomized Controlled Pilot Trial of the Effects of
   Exercise on Physical Function and Clinical Health Risk Factors in Older
   Military Veterans With PTSD
SO JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL
   SCIENCES
LA English
DT Article
DE Metabolic syndrome; Health disparities; Mental health; Post-traumatic
   stress; Aerobic endurance
ID POSTTRAUMATIC-STRESS-DISORDER; MEANINGFUL CHANGE; ACTIVITY HABITS; WAR
   VETERANS; PERFORMANCE; ASSOCIATION; DEPRESSION; MORTALITY; CARE;
   METAANALYSIS
AB Background: Military veterans living with post-traumatic stress disorder (PTSD) face significant physical and functional health disparities, which are often aggravated over time and in the context aging. Evidence has shown that physical activity can positively impact age-related health conditions, yet exercise trials in older adults with mental disorders are rare. Our study was a tailored and targeted pilot exercise intervention for older veterans with PTSD.
   Methods: Fifty-four older veterans with PTSD (mean age = 67.4 years, 90.7% male, 85.2% non-white) were randomized to supervised exercise (n = 38) or wait-list usual care (n = 18) for 12 weeks. Physical activity (MET-min/wk) and aerobic endurance (assessed with the 6-minute walk test) were primary outcomes. Secondary outcomes were physical performance (strength, mobility, balance), cardiometabolic risk factors (eg, waist circumference), and health-related quality of life.
   Results: At 12 weeks, a large effect of the intervention on physical activity levels (Cohen's d = 1.37) was observed compared to wait-list usual care. Aerobic endurance improved by 69 m in the exercise group compared to 10 m in wait-list group, reflecting a moderate between-group effect (Cohen's d = 0.50). Between-group differences on 12-week changes in physical performance, cardiometabolic risk factors, and health-related quality of life ranged from small to large effects (Cohen's d = 0.28-1.48), favoring the exercise arm.
   Conclusion: Participation in supervised exercise improved aerobic endurance, physical performance, and health-related clinical factors in older veterans with PTSD; a medically complex population with multiple morbidity. Group exercise is a low-cost, low-stigma intervention, and implementation efforts among older veterans with PTSD warrants further consideration.
C1 [Hall, Katherine S.; Morey, Miriam C.; Sloane, Richard; Pebole, Michelle M.] VA Durham Healthcare Syst, Geriatr Res Educ & Clin Ctr, 508 Fulton St,GRECC 182, Durham, NC 27705 USA.
   [Hall, Katherine S.; Morey, Miriam C.; Bosworth, Hayden B.] Duke Univ, Dept Populat Hlth Sci, Durham, NC USA.
   [Beckham, Jean C.] VA Durham Healthcare Syst, Mental Illness Res Educ & Clin Ctr, Durham, NC 27705 USA.
   [Beckham, Jean C.; Bosworth, Hayden B.] Duke Univ, Dept Psychiat & Behav Sci, Durham, NC USA.
   [Bosworth, Hayden B.] VA Durham Healthcare Syst, Hlth Serv Res & Dev, Ctr Innovat Accelerate Discovery & Practice Trans, Durham, NC 27705 USA.
   [Sloane, Richard; Pieper, Carl F.] Duke Univ, Dept Biostat & Bioinformat, Durham, NC USA.
C3 Geriatric Research Education & Clinical Center; Duke University; Duke
   University; Duke University
RP Hall, KS (corresponding author), VA Durham Healthcare Syst, Geriatr Res Educ & Clin Ctr, 508 Fulton St,GRECC 182, Durham, NC 27705 USA.
EM katherine.hall@duke.edu
OI Pieper, Carl/0000-0003-4809-1725; Morey, Miriam/0000-0002-1230-7590
FU Department of Veterans Affairs, Rehabilitation Research and Development
   Service [2RX001316]; Duke Claude D. Pepper Older Americans Independence
   Center [P30 AG028716]
FX This project is supported by the Department of Veterans Affairs,
   Rehabilitation Research and Development Service (2RX001316, K.S.H.).
   K.S.H. and M.C.M. also receive support from the Duke Claude D. Pepper
   Older Americans Independence Center (P30 AG028716).
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NR 61
TC 14
Z9 16
U1 10
U2 23
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 1079-5006
EI 1758-535X
J9 J GERONTOL A-BIOL
JI J. Gerontol. Ser. A-Biol. Sci. Med. Sci.
PD NOV
PY 2020
VL 75
IS 11
BP 2130
EP 2138
DI 10.1093/gerona/glz255
PG 9
WC Geriatrics & Gerontology; Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA OD5CR
UT WOS:000579870000017
PM 31646339
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Leutner, M
   Dervic, E
   Bellach, L
   Klimek, P
   Thurner, S
   Kautzky, A
AF Leutner, Michael
   Dervic, Elma
   Bellach, Luise
   Klimek, Peter
   Thurner, Stefan
   Kautzky, Alexander
TI Obesity as pleiotropic risk state for metabolic and mental health
   throughout life
SO TRANSLATIONAL PSYCHIATRY
LA English
DT Article
ID PRACTICE GUIDELINES; AMERICAN-COLLEGE; WEIGHT-GAIN; DEPRESSION;
   DISORDERS; ASSOCIATION; OVERWEIGHT; WOMEN; COMORBIDITY; PREVALENCE
AB Obesity, a highly prevalent disorder and central diagnosis of the metabolic syndrome, is linked to mental health by clinical observations and biological pathways. Patients with a diagnosis of obesity may show long-lasting increases in risk for receiving psychiatric co-diagnoses. Austrian national registry data of inpatient services from 1997 to 2014 were analyzed to detect associations between a hospital diagnosis of obesity (ICD-10: E66) and disorders grouped by level-3 ICD-10 codes. Data were stratified by age decades and associations between each pair of diagnoses were computed with the Cochran-Mantel-Haenszel method, providing odds ratios (OR) and p values corrected for multiple testing. Further, directions of the associations were assessed by calculating time-order-ratios. Receiving a diagnosis of obesity significantly increased the odds for a large spectrum of psychiatric disorders across all age groups, including depression, psychosis-spectrum, anxiety, eating and personality disorders (all p(corr) < 0.01, all OR > 1.5). For all co-diagnoses except for psychosis-spectrum, obesity was significantly more often the diagnosis received first. Further, significant sex differences were found for most disorders, with women showing increased risk for all disorders except schizophrenia and nicotine addiction. In addition to the well-recognized role in promoting disorders related to the metabolic syndrome and severe cardiometabolic sequalae, obesity commonly precedes severe mental health disorders. Risk is most pronounced in young age groups and particularly increased in female patients. Consequently, thorough screening for mental health problems in patients with obesity is urgently called for to allow prevention and facilitate adequate treatment.
C1 [Leutner, Michael; Bellach, Luise] Med Univ Vienna, Dept Internal Med 3, Clin Div Endocrinol & Metab, Waehringer Guertel 18-20, A-1090 Vienna, Austria.
   [Dervic, Elma; Klimek, Peter; Thurner, Stefan] Med Univ Vienna, Sect Sci Complex Syst, CeMSIIS, Spitalgasse 23, A-1090 Vienna, Austria.
   [Dervic, Elma; Klimek, Peter; Thurner, Stefan] Complex Sci Hub Vienna, Josefstaedter Str 39, A-1080 Vienna, Austria.
   [Kautzky, Alexander] Med Univ Vienna, Dept Psychiat & Psychotherapy, Waehringer Guertel 18-20, A-1090 Vienna, Austria.
C3 Medical University of Vienna; Medical University of Vienna; Medical
   University of Vienna
RP Kautzky, A (corresponding author), Med Univ Vienna, Dept Psychiat & Psychotherapy, Waehringer Guertel 18-20, A-1090 Vienna, Austria.
EM alexander.kautzky@meduniwien.ac.at
RI Klimek, Peter/AAC-2723-2019
FU Karolinska Institute
FX The financial support was received for analyses relevant to this study.
   Open access funding provided by Karolinska Institute.
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NR 58
TC 27
Z9 27
U1 1
U2 3
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 2158-3188
J9 TRANSL PSYCHIAT
JI Transl. Psychiatr.
PD MAY 30
PY 2023
VL 13
IS 1
AR 175
DI 10.1038/s41398-023-02447-w
PG 12
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychiatry
GA H6QA4
UT WOS:000997173800001
PM 37248222
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Martinac, M
   Pehar, D
   Karlovic, D
   Babic, D
   Marcinko, D
   Jakovljevic, M
AF Martinac, Marko
   Pehar, Davor
   Karlovic, Dalibor
   Babic, Dragan
   Marcinko, Darko
   Jakovljevic, Miro
TI METABOLIC SYNDROME, ACTIVITY OF THE HYPOTHALAMIC-PITUITARY-ADRENAL AXIS
   AND INFLAMMATORY MEDIATORS IN DEPRESSIVE DISORDER
SO ACTA CLINICA CROATICA
LA English
DT Review
DE Depressive disorder; Metabolic syndrome X; Cytokines; Hypothalamic,
   hypophyseal system
ID C-REACTIVE PROTEIN; IMPAIRED GLUCOSE-TOLERANCE; TUMOR-NECROSIS-FACTOR;
   HUMAN ADIPOSE-TISSUE; 3RD NATIONAL-HEALTH; INSULIN-RESISTANCE; MAJOR
   DEPRESSION; CARDIOVASCULAR-DISEASE; TNF-ALPHA; PSYCHOLOGICAL RISK
AB Depression has been associated with various cardiovascular risk factors such as hypertension, obesity, atherogenic dyslipidemia and hyperglycemia. In depressive disorder, hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis and changes in the immune system have been observed. On the other hand, somatic diseases such as obesity, hyperlipidemia, hypertension and diabetes mellitus type 2 are now perceived as important comorbid conditions in patients with depression. The pathogenesis of the metabolic syndrome and depression is complex and poorly researched; however, it is considered that the interaction of chronic stress, psychotrauma, hypercotisolism and disturbed immune functions contribute to the development of these disorders. The aim of the study was to investigate the relationship between depression and metabolic syndrome regarding the HPA axis dysfunction and altered inflammatory processes. Literature search in Medline and other databases included articles written in English published between 1985 and 2012. Analysis of the literature was conducted using a systematic approach with the search terms such as depression, metabolic syndrome, inflammation, cytokines, glucocorticoids, cortisol, and HPA axis. In conclusion, the relationship between depression and metabolic syndrome is still a subject of controversy. Further prospective studies are required to clarify the possible causal relationship between depression and metabolic syndrome and its components. Furthermore, it is important to explore the possibility of a common biologic mechanism in the pathogenesis of these two disorders, in which special attention should be paid to the immune system function, especially the possible specific mechanisms by which cytokines can induce and maintain depressive symptoms and metabolic disorders. The data presented here emphasize the importance of recognition and treatment of depressive disorders with consequent reduction in the incidence of metabolic syndrome, but also the need of regular search for metabolic disorders and their treatment to avoid all of these adverse effects and maybe reduce the incidence of depressive disorders.
C1 [Martinac, Marko; Pehar, Davor] Mostar Hlth Ctr, Mostar Ctr Mental Hlth, Hrvatskih Branitelja Bb 88000, Mostar, Bosnia & Herceg.
   [Karlovic, Dalibor] Sestre Milosrdnice Univ Hosp Ctr, Clin Dept Psychiat, Zagreb, Croatia.
   [Babic, Dragan] Mostar Univ Hosp, Clin Dept Psychiat, Mostar, Bosnia & Herceg.
   [Marcinko, Darko; Jakovljevic, Miro] Zagreb Univ Hosp Ctr, Clin Dept Psychiat, Zagreb, Croatia.
C3 University of Mostar; University of Zagreb; University of Mostar;
   University of Zagreb; UNIVERSITY ZAGREB HOSPITAL
RP Martinac, M (corresponding author), Mostar Hlth Ctr, Mostar Ctr Mental Hlth, Hrvatskih Branitelja Bb 88000, Mostar, Bosnia & Herceg.
EM marko.martinac@tel.net.ba
OI Martinac, Marko/0000-0001-9144-6427
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NR 137
TC 65
Z9 72
U1 1
U2 14
PU SESTRE MILOSRDNICE UNIV HOSPITAL
PI ZAGREB
PA VINOGRADSKA C 29, ZAGREB, HR-10000, CROATIA
SN 0353-9466
EI 1333-9451
J9 ACTA CLIN CROAT
JI Acta Clin. Croat.
PD MAR
PY 2014
VL 53
IS 1
BP 55
EP 71
PG 17
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA AI8ZZ
UT WOS:000337216800008
PM 24974667
DA 2025-06-11
ER

PT J
AU Ford, ES
   Mokdad, AH
   Giles, WH
   Brown, DW
AF Ford, ES
   Mokdad, AH
   Giles, WH
   Brown, DW
TI The metabolic syndrome and antioxidant concentrations - Findings from
   the Third National Health and Nutrition Examination Survey
SO DIABETES
LA English
DT Article
ID DIABETES-MELLITUS INCIDENCE; INSULIN-RESISTANCE SYNDROME; C-REACTIVE
   PROTEIN; VITAMIN-E; CARDIOVASCULAR-DISEASE; OXIDATIVE STRESS;
   ALPHA-TOCOPHEROL; FREE-RADICALS; FOLLOW-UP; RISK
AB Oxidative stress may play a role in the pathophysiology of diabetes and cardiovascular disease, but little is known about antioxidant status among individuals with the metabolic syndrome who are at high risk for developing these conditions. Using data from the Third National Health and Nutrition Examination Survey (1988 - 1994), we compared circulating concentrations of vitamins A, C, and E; retinyl esters; five carotenoids; and selenium in 8,808 U.S. adults aged greater than or equal to20 years with and without the metabolic syndrome. After adjusting for age, sex, race or ethnicity, education, smoking status, cotinine concentration, physical activity, fruit and vegetable intake, and vitamin or mineral use, participants with the metabolic syndrome had significantly lower concentrations of retinyl esters, vitamin C, and carotenoids, except lycopene. With additional adjustment for serum lipid concentrations, vitamin E concentrations were significantly lower in participants with the metabolic syndrome than those without the syndrome. Retinol concentrations were similar between the two groups. After excluding participants with diabetes, the results were very similar. Consumption of fruits and vegetables was also lower among people with the metabolic syndrome. Adults with the metabolic syndrome have suboptimal concentrations of several antioxidants, which may partially explain their increased risk for diabetes and cardiovascular disease.
C1 Ctr Dis Control & Prevent, Natl Ctr Chron Ctr, Div Adult & Community Hlth, Atlanta, GA 30341 USA.
C3 Centers for Disease Control & Prevention - USA
RP Ctr Dis Control & Prevent, Natl Ctr Chron Ctr, Div Adult & Community Hlth, 4770 Buford Hwy K66, Atlanta, GA 30341 USA.
EM eford@cdc.gov
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NR 46
TC 345
Z9 382
U1 0
U2 15
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0012-1797
EI 1939-327X
J9 DIABETES
JI Diabetes
PD SEP
PY 2003
VL 52
IS 9
BP 2346
EP 2352
DI 10.2337/diabetes.52.9.2346
PG 7
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 716KP
UT WOS:000185027600020
PM 12941775
OA Bronze, Green Submitted
DA 2025-06-11
ER

PT J
AU Kalra, J
   Dhar, A
AF Kalra, Jaspreet
   Dhar, Arti
TI Double-stranded RNA-dependent protein kinase signalling and paradigms of
   cardiometabolic syndrome
SO FUNDAMENTAL & CLINICAL PHARMACOLOGY
LA English
DT Review
DE apoptosis; diabetic cardiomyopathy; double-stranded RNA-dependent
   protein kinase; hypertension; inflammation; metabolic syndrome;
   oxidative stress
ID ENDOPLASMIC-RETICULUM STRESS; LOW-GRADE INFLAMMATION; BETA-CELL
   DYSFUNCTION; C-REACTIVE PROTEIN; OXIDATIVE STRESS; INSULIN-RESISTANCE;
   METABOLIC SYNDROME; PKR ACTIVATION; T-CELLS; KAPPA-B
AB Metabolic syndrome (Met S) is a collection of the most severe cardiometabolic risk factors that encompasses raised fasting plasma glucose, dyslipidaemia, insulin resistance, obesity and hypertension. The precise mechanism underlying the pathogenesis of Met S remains unclear. More often oxidative stress, inflammation and apoptosis are implicated in its aetiology. Recently, double-stranded RNA-dependent protein kinase has been found to intersect at the cross-road of oxidative stress, inflammation and apoptosis in several metabolic diseases. Therefore, an effort has been made in the present review to discuss the role of double-stranded RNA-dependent protein kinase and above-mentioned mechanisms in the progression of Met S, along with its interlinking in major clinical manifestations of Met S such as hypertension and diabetic cardiomyopathy.
C1 [Kalra, Jaspreet; Dhar, Arti] Birla Inst Technol & Sci Pilani, Dept Pharm, Hyderabad Campus, Hyderabad 500078, Andhra Pradesh, India.
C3 Birla Institute of Technology & Science Pilani (BITS Pilani)
RP Dhar, A (corresponding author), Birla Inst Technol & Sci Pilani, Dept Pharm, Hyderabad Campus, Hyderabad 500078, Andhra Pradesh, India.
EM artidhar@hyderabad.bits-pilani.ac.in
OI Dhar, Arti/0000-0003-1892-6875; Kalra, Jaspreet/0000-0002-3720-8994
FU Department of Science and Technology (DST-SERB); Center for Scientific
   and Industrial Research (CSIR), India
FX This work was supported by a grant from Department of Science and
   Technology (DST-SERB) under the young scientist scheme and Center for
   Scientific and Industrial Research (CSIR), India, to Arti Dhar.
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NR 159
TC 6
Z9 6
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0767-3981
EI 1472-8206
J9 FUND CLIN PHARMACOL
JI Fundam. Clin. Pharmacol.
PD JUN
PY 2017
VL 31
IS 3
BP 265
EP 279
DI 10.1111/fcp.12261
PG 15
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA EU6XE
UT WOS:000401178400002
PM 27992964
DA 2025-06-11
ER

PT J
AU Brumby, S
   Chandrasekara, A
   Kremer, P
   Torres, S
   McCoombe, S
   Lewandowski, P
AF Brumby, Susan
   Chandrasekara, Ananda
   Kremer, Peter
   Torres, Susan
   McCoombe, Scott
   Lewandowski, Paul
TI The effect of physical activity on psychological distress, cortisol and
   obesity: results of the farming fit intervention program
SO BMC PUBLIC HEALTH
LA English
DT Article
DE Obesity; Cortisol; Mental health; Rural; Farmer
ID METABOLIC SYNDROME; DEPRESSION; STRESS
AB Background: Rural and regional Australians have a higher likelihood of mental illness throughout their lifetime than people living in major cities, although the underlying reasons are not yet well defined. Additionally, rural populations experience more lifestyle associated co-morbidities including obesity, diabetes and cardiovascular disease. Research conducted by the National Centre for Farmer Health between 2004 and 2009 revealed a positive correlation between obesity and psychological distress among the farming community. Chronic stress is known to overstimulate the regulation of the hypothalamic-pituitary-adrenal (HPA) axis and cortisol secretion which are associated with abdominal adiposity. Increasing physical activity may normalise cortisol secretion and thereby positively impact both physical and mental health. This paper assesses the effects of increasing physical activity on obesity, health behaviors and mental health in Victorian farming men and women.
   Methods: Farming Fit was a six month quasi-experimental (convenience sample) longitudinal design control-intervention study. Overweight or obese (BMI >= 25 kg/m(2)) farm men (n = 43) and women (n = 29) were recruited with demographic, health behaviors, anthropometric, blood pressure and biochemistry data collected at baseline and at a six months. Salivary cortisol and depression anxiety stress scale results were collected at baseline, three and six months. The intervention group (n = 37) received a personalized exercise program and regular phone coaching to promote physical activity. Results: The intervention group showed significant reductions in body weight and waist circumference.
   Results indicated that following the six month exercise program, the intervention group were 2.64 +/- 0.65 kg lighter (p < 0.001), had reduced waist circumference by 2.01 +/- 0.86 cm (p = 0.02) and BMI by 0.97 +/- 0.22 kg/m(2) (p < 0.001) relative to the control group.
   Conclusion: Increasing physical activity altered measures of obesity in farm men and women but did not affect mental health measures or cortisol secretion levels.
C1 [Brumby, Susan; Chandrasekara, Ananda; McCoombe, Scott] Western Dist Hlth Serv, Natl Ctr Farmer Hlth, Hamilton, Vic 3300, Australia.
   [Brumby, Susan; Chandrasekara, Ananda; McCoombe, Scott; Lewandowski, Paul] Deakin Univ, Sch Med, Geelong, Vic 3216, Australia.
   [Kremer, Peter] Deakin Univ, Sch Exercise & Nutr Sci, Geelong, Vic 3216, Australia.
   [Torres, Susan] Deakin Univ, Sch Exercise & Nutr Sci, Burwood, Vic 3125, Australia.
C3 Deakin University; Deakin University; Deakin University
RP Brumby, S (corresponding author), Western Dist Hlth Serv, Natl Ctr Farmer Hlth, POB 283, Hamilton, Vic 3300, Australia.
EM susan.brumby@deakin.edu.au
RI Chandrasekara, Ananda/AAV-4623-2021; Kremer, Peter/I-8202-2019
OI Chandrasekara, Prof. Ananda/0000-0003-0947-6083; McCoombe,
   Scott/0000-0001-6717-7511; Kremer, Peter/0000-0003-2476-1958; Brumby,
   Susan/0000-0001-6332-3374
FU beyondblue; Victorian Department of Primary Industries
FX We acknowledge the funding agencies involved in this study: beyondblue
   and the Victorian Department of Primary Industries. We would also like
   to thank and acknowledge the contributions of Jason Thomas, Hannah
   Simkin, Tracey Hatherell, Cate Mercer-Grant, Wayne Munro, April
   Brinkmann, Jo Williams, Bianca Todd, SFF health professionals and the
   farm men and women participating.
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NR 26
TC 23
Z9 29
U1 2
U2 46
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2458
J9 BMC PUBLIC HEALTH
JI BMC Public Health
PD OCT 28
PY 2013
VL 13
AR 1018
DI 10.1186/1471-2458-13-1018
PG 6
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA 284BH
UT WOS:000329290500002
PM 24165391
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Manolis, TA
   Manolis, AA
   Melita, H
   Manolis, AS
AF Manolis, Theodora A. A.
   Manolis, Antonis A. A.
   Melita, Helen
   Manolis, Antonis S. S.
TI Neuropsychiatric disorders in patients with heart failure: not to be
   ignored
SO HEART FAILURE REVIEWS
LA English
DT Article
DE Heart failure; Depression; Anxiety; Psychiatric disorder; Stress;
   Insomnia; Cognitive dysfunction; Antidepressants; Cognitive behavioral
   therapy
ID QUALITY-OF-LIFE; IMPLANTABLE CARDIOVERTER-DEFIBRILLATOR; CARDIAC
   RESYNCHRONIZATION THERAPY; GENERALIZED ANXIETY DISORDER; SYMPATHETIC
   NERVOUS ACTIVITY; MAJOR DEPRESSIVE DISORDER; ALL-CAUSE MORTALITY;
   C-REACTIVE PROTEIN; ENDOTHELIAL FUNCTION; METABOLIC SYNDROME
AB Among various neuropsychiatric disorders, depression and anxiety are commonly encountered in patients with heart failure (HF), reported in & GE; 50% of patients attending a HF clinic, but may frequently elude clinician's attention. Both disorders are associated with the development and progression of HF, incurring higher rates of morbidity/mortality, probably via physiologic and behavioral mechanisms. Patients with devices and/or advanced HF are more severely affected, especially early following device receipt. In addition, various other neuropsychiatric and neuropsychological disorders and symptoms of these and other disorders occur in and impact HF patients, including sleep disorders and cognitive impairment, which further interact with and amplify depression and anxiety. Mechanisms involved in the link between neuropsychiatric/neuropsychological disorders and HF may relate to pathophysiological processes, lifestyle factors, and behavioral patterns. Among the pathophysiological factors, inflammation, autonomic dysfunction, endothelial dysfunction, thrombotic mechanisms, and dysregulation of the hypothalamic-pituitary-adrenal axis may play a significant role as they are implicated in the pathogenesis, progression, and prognosis of HF. Multimodal psychiatric management strategies with flexible approaches, using antidepressants/anxiolytics/atypical antipsychotics and various psychotherapies such as cognitive behavioral therapy combined with exercise adjusted to patients' care and needs, appear promising in this patient group. Choosing agents with a higher efficacy/safety profile is a prudent strategy. Although depression and anxiety are risk factors for mortality in HF patients, indiscriminate use of psychiatric medications may not improve or even worsen survival when one neglects to closely monitor for potential proarrhythmic and other side effects. Newer meta-analytic data in HF patients indicate no increase in mortality for newer antidepressants, while secondary analyses show improved survival in patients who achieved remission of depressive symptoms.
C1 [Manolis, Theodora A. A.] Aiginiteio Univ Hosp, Athens, Greece.
   [Manolis, Antonis A. A.] Univ Patras, Sch Med, Patras, Greece.
   [Melita, Helen] Onassis Cardiac Surg Ctr, Athens, Greece.
   [Manolis, Antonis S. S.] Athens Univ, Ippokrateio Hosp, Sch Med, Dept Cardiol 1, Vas Sofias 114, Athens 11527, Greece.
C3 University of Patras; Onassis Cardiac Surgery Center; Athens Medical
   School; National & Kapodistrian University of Athens
RP Manolis, AS (corresponding author), Athens Univ, Ippokrateio Hosp, Sch Med, Dept Cardiol 1, Vas Sofias 114, Athens 11527, Greece.
EM asm@otenet.gr
RI Manolis, Antonis/F-5003-2014
OI Manolis, Antonis/0000-0002-0336-4745
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NR 244
TC 7
Z9 8
U1 3
U2 21
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1382-4147
EI 1573-7322
J9 HEART FAIL REV
JI Heart Fail. Rev.
PD JUL
PY 2023
VL 28
IS 4
BP 821
EP 858
DI 10.1007/s10741-022-10290-2
EA DEC 2022
PG 38
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA K0BV0
UT WOS:000903149100001
PM 36547867
DA 2025-06-11
ER

PT J
AU Moreira, FA
   Grieb, M
   Lutz, B
AF Moreira, Fabricio A.
   Grieb, Maximilian
   Lutz, Beat
TI Central side-effects of therapies based on CB1 cannabinoid
   receptor agonists and antagonists: focus on anxiety and depression
SO BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Article
DE cannabinoids; anxiety; depression; Sativex; dronabinol; nabilone;
   rimonabant; taranabant
ID CARDIOMETABOLIC RISK-FACTORS; ANTIDEPRESSANT-LIKE ACTIVITY;
   LITHIUM-PAIRED CONTEXT; ENDOCANNABINOID SYSTEM; INVERSE AGONIST;
   ANXIOLYTIC-LIKE; OVERWEIGHT PATIENTS; SMOKED MARIJUANA; NEUROPATHIC
   PAIN; REDUCED ANXIETY
AB Both agonists (e.g. Delta(9)-tetrahydrocannabinol, nabilone) and antagonists (e.g. rimonabant, taranabant) of the cannabinoid type-1 (CB1) receptor have been explored as therapeutic agents in diverse fields of medicine Such as pain management and obesity with associated metabolic dysregulation, respectively. CB, receptors are widely distributed in the central nervous system and are involved in the modulation of emotion, stress and habituation responses, behaviours that are thought to be dysregulated in human psychiatric disorders. Accordingly, CB1 receptor activation may, in some cases, precipitate episodes of psychosis and panic, while its inhibition may lead to behaviours reminiscent of depression and anxiety-related disorders. The present review discusses these side-effects, which have to be taken into account in the therapeutic exploitation of the endocannabinoid system. (C) 2008 Elsevier Ltd. All rights reserved.
C1 [Moreira, Fabricio A.; Grieb, Maximilian; Lutz, Beat] Johannes Gutenberg Univ Mainz, Dept Physiol Chem, D-55099 Mainz, Germany.
C3 Johannes Gutenberg University of Mainz
RP Lutz, B (corresponding author), Johannes Gutenberg Univ Mainz, Dept Physiol Chem, Duesbergweg 6, D-55099 Mainz, Germany.
EM blutz@uni-mainz.de
RI Lutz, Beat/AFK-6229-2022
OI Moreira, Fabricio/0000-0002-0824-7302
FU Alexander von Humboldt Foundation (Germany)
FX FA.M. was supported by a grant from the Alexander von Humboldt
   Foundation (Germany). We would also like to thank Dr (Krisztina Monory
   for critically reading the manuscript.
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NR 100
TC 220
Z9 248
U1 0
U2 30
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1521-690X
EI 1532-1908
J9 BEST PRACT RES CL EN
JI Best Pract. Res. Clin. Endoc. Metab.
PD FEB
PY 2009
VL 23
IS 1
BP 133
EP 144
DI 10.1016/j.beem.2008.09.003
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 425JC
UT WOS:000264631800011
PM 19285266
DA 2025-06-11
ER

PT J
AU Dortland, AKBV
   Giltay, EJ
   van Veen, T
   Zitman, FG
   Penninx, BWJH
AF Dortland, Arianne K. B. van Reedt
   Giltay, Erik J.
   van Veen, Tineke
   Zitman, Frans G.
   Penninx, Brenda W. J. H.
TI Longitudinal Relationship of Depressive and Anxiety Symptoms With
   Dyslipidemia and Abdominal Obesity
SO PSYCHOSOMATIC MEDICINE
LA English
DT Article
DE depression; anxiety; lipids; cholesterol; abdominal obesity; waist
   circumference
ID CORONARY-HEART-DISEASE; C-REACTIVE PROTEIN; MENTAL-HEALTH SURVEY;
   METABOLIC SYNDROME; RISK-FACTORS; MAJOR DEPRESSION; YOUNG-ADULTS;
   NETHERLANDS; ASSOCIATION; DISORDERS
AB Objective: Previous research indicates that patients with severe symptoms of depression or anxiety are prone toward the development of dyslipidemia and abdominal obesity. We sought to study these associations longitudinally. Methods: Among 2126 Netherlands Study of Depression and Anxiety participants, we studied whether severity of depressive (Inventory of Depressive Symptoms) or anxiety (Beck Anxiety Inventory) symptoms at baseline was associated with changes in lipids (i.e., total, high-density lipoprotein [HDL] or low-density lipoprotein cholesterol, and triglycerides) or waist circumference during a 2-year follow-up period. We also examined whether changes in severity of symptoms were associated with changes in lipid or waist circumference levels over these 2 years. Multivariate linear regression analyses were adjusted for age, sex, education, and tobacco consumption. Results: Baseline symptoms of depression or anxiety predicted a decrease in HDL cholesterol (adjusted beta = -.062 [p = .003] and beta = -.050 [p = .02], respectively) and an increase in waist circumference (adjusted beta = .060 [p = .01] and beta = .053 [p = .02], respectively) for 2 years. Reduction of symptoms of depression or anxiety over time did not coincide with an amelioration of lipid or waist circumference values. Conclusions: People with initially severe symptoms of depression or anxiety showed a subsequent decrease in HDL cholesterol levels and an increase in abdominal obesity over time, independent of a potential reduction in symptom severity in this period. Therefore, such people are at elongated and increasing risk for dyslipidemia and obesity, predisposing them to cardiovascular disease.
C1 [Dortland, Arianne K. B. van Reedt; Giltay, Erik J.; van Veen, Tineke; Zitman, Frans G.; Penninx, Brenda W. J. H.] Leiden Univ, Dept Psychiat, Med Ctr, NL-2300 RC Leiden, Netherlands.
   [Penninx, Brenda W. J. H.] Vrije Univ Amsterdam, Dept Psychiat, Med Ctr, Amsterdam, Netherlands.
   [Penninx, Brenda W. J. H.] Univ Groningen, Univ Med Ctr Groningen, Dept Psychiat, NL-9713 AV Groningen, Netherlands.
C3 Leiden University - Excl LUMC; Leiden University; Leiden University
   Medical Center (LUMC); Vrije Universiteit Amsterdam; University of
   Groningen
RP Dortland, AKBV (corresponding author), Leiden Univ, Dept Psychiat, Med Ctr, POB 9600, NL-2300 RC Leiden, Netherlands.
EM akbvanreedtdortland@lumc.nl
RI Zitman, Frans/E-7705-2010; Giltay, Erik/AAL-9948-2021; Penninx,
   Brenda/S-7627-2017
OI Giltay, Erik J./0000-0001-8874-2292
FU Geestkracht program of the Netherlands Organisation for Health Research
   and Development (ZonMw) [10-000-1002]; VU University Medical Centre; GGZ
   inGeest, Arkin; Leiden University Medical Centre; GGZ Rivierduinen;
   University Medical Centre Groningen, Lentis; GGZ Friesland; GGZ Drenthe;
   Scientific Institute for Quality of Health Care [IQ Healthcare];
   Netherlands Institute for Health Services Research [NIVEL]; Netherlands
   Institute of Mental Health and Addiction [Trimbos]; NWO [VIDI
   917.66.320]
FX The infrastructure for the NESDA study (www.nesda.nl) is funded through
   the Geestkracht program of the Netherlands Organisation for Health
   Research and Development (ZonMw, grant no. 10-000-1002) and is supported
   by participating universities and mental health care organizations (VU
   University Medical Centre; GGZ inGeest, Arkin; Leiden University Medical
   Centre; GGZ Rivierduinen; University Medical Centre Groningen, Lentis;
   GGZ Friesland; GGZ Drenthe; Scientific Institute for Quality of Health
   Care [IQ Healthcare]; Netherlands Institute for Health Services Research
   [NIVEL]; and Netherlands Institute of Mental Health and Addiction
   [Trimbos]). Data analyses were supported by NWO grant (VIDI 917.66.320;
   to Dr. Penninx).
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NR 66
TC 77
Z9 89
U1 2
U2 27
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0033-3174
EI 1534-7796
J9 PSYCHOSOM MED
JI Psychosom. Med.
PD JAN
PY 2013
VL 75
IS 1
BP 83
EP 89
DI 10.1097/PSY.0b013e318274d30f
PG 7
WC Psychiatry; Psychology; Psychology, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry; Psychology
GA 070UY
UT WOS:000313539400011
PM 23197842
DA 2025-06-11
ER

PT J
AU Kim, JR
   Kim, HN
   Song, SW
AF Kim, Ji-Ryang
   Kim, Ha-Na
   Song, Sang-Wook
TI Associations among inflammation, mental health, and quality of life in
   adults with metabolic syndrome
SO DIABETOLOGY & METABOLIC SYNDROME
LA English
DT Article
DE Metabolic syndrome; Inflammation; Mental health; Quality of life
ID C-REACTIVE PROTEIN; CORONARY-HEART-DISEASE; DEPRESSIVE SYMPTOMS; MAJOR
   DEPRESSION; SUICIDE ATTEMPT; OLDER-ADULTS; WORK STRESS; CRP LEVELS;
   HS-CRP; OBESITY
AB Background: Metabolic syndrome (MetS), a pro-inflammatory state, has become increasingly common worldwide and is a major risk factor for type 2 diabetes mellitus and cardiovascular disease. Recently, studies on the relationships among inflammation, mental health, quality of life, and other diseases have been conducted.
   Methods: We investigated the relationship between serum high-sensitivity C-reactive protein (hs-CRP) levels, as an indicator of inflammation, and the quality of life and psychiatric symptoms of Korean adults with MetS. The analysis used data from the Korean National Health and Nutrition Examination Survey, a cross-sectional survey of Korean civilians conducted from January to December 2015. Data from 1600 participants were analyzed in this study. Quality of life was assessed using the EuroQol 5-dimension (EQ-5D) instrument.
   Results: Serum hs-CRP levels showed a significant inverse correlation with the EQ-5D index of the overall quality of life. High serum hs-CRP levels were positively associated with mobility problems and suicidal ideation in adults with MetS (multivariate-adjusted odds ratio [OR] 1.66, 95% confidence interval [CI] 1.03-2.66, p = 0.036; and multivariate-adjusted OR 2.48, 95% CI 1.23-4.99, p = 0.011).
   Conclusions: These findings suggest that the elevated inflammatory status in MetS is associated with decreased quality of life and mental health problems. Further prospective studies are needed to confirm the impact of inflammation on the quality of life and mental health of adults with MetS.
C1 [Kim, Ji-Ryang; Kim, Ha-Na; Song, Sang-Wook] Catholic Univ Korea, Coll Med, St Vincents Hosp, Dept Family Med, Jungbu Daero 93, Suwon 16247, Gyeonggi Do, South Korea.
C3 Catholic University of Korea
RP Song, SW (corresponding author), Catholic Univ Korea, Coll Med, St Vincents Hosp, Dept Family Med, Jungbu Daero 93, Suwon 16247, Gyeonggi Do, South Korea.
EM sswkoj@unitel.co.kr
FU Department of Biostatistics of the Catholic Research Coordinating Center
FX Statistical consultation was supported by the Department of
   Biostatistics of the Catholic Research Coordinating Center.
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NR 51
TC 17
Z9 18
U1 1
U2 12
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1758-5996
J9 DIABETOL METAB SYNDR
JI Diabetol. Metab. Syndr.
PD AUG 31
PY 2018
VL 10
AR 66
DI 10.1186/s13098-018-0367-9
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA GS2TA
UT WOS:000443408600001
PM 30186371
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Bolton, PS
   Knight, M
   Kopeski, LM
AF Bolton, Paula S.
   Knight, Margaret
   Kopeski, Lynne M.
TI Metabolic Syndrome Psychiatric-Mental Health Nurses' Knowledge of Risks
   and Care Practices
SO JOURNAL OF PSYCHOSOCIAL NURSING AND MENTAL HEALTH SERVICES
LA English
DT Article
ID PEOPLE; ILLNESS
AB Comorbidity of serious mental illness (SMI) and metabolic syndrome contributes to the reduced lifespan of individuals with SMI. Integration of physical and mental health care has been slow. The current study explored the level of knowledge of metabolic syndrome and practices of psychiatric-mental health nurses related to metabolic syndrome risks. Using a knowledge survey and adapted Mental Health Nurse Physical Health Attitude Scale, the researchers surveyed 175 psychiatric nurses through an online social media website. Of respondents, 52% identified all five risk factors for metabolic syndrome. However, only 70.8% knew all recommended physiological monitoring markers. There was no significant relationship between knowledge score and integration of physical health care activities in practice; however, knowledge regarding metabolic syndrome risk factors was high. Currently, integration of this knowledge into care is lagging. Nurse educators must integrate assessment, planning, intervention, and evaluation of physical health status and related needs of individuals with SMI.
C1 [Bolton, Paula S.] McLean Hosp, Dept Internal Med, 115 Mill St, Belmont, MA 02478 USA.
   [Kopeski, Lynne M.] McLean Hosp, Behav Hlth Partial Program, 115 Mill St, Belmont, MA 02178 USA.
   [Knight, Margaret] Univ Massachusetts Lowell, Lowell, MA USA.
C3 Harvard University; Harvard University Medical Affiliates; McLean
   Hospital; Harvard University; Harvard University Medical Affiliates;
   McLean Hospital; University of Massachusetts System; University of
   Massachusetts Lowell
RP Bolton, PS (corresponding author), McLean Hosp, Dept Internal Med, 115 Mill St, Belmont, MA 02478 USA.
EM pbolton@partners.org
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NR 16
TC 14
Z9 16
U1 0
U2 4
PU SLACK INC
PI THOROFARE
PA 6900 GROVE RD, THOROFARE, NJ 08086 USA
SN 0279-3695
EI 1938-2413
J9 J PSYCHOSOC NURS MEN
JI J. Psychosoc. Nurs. Ment. Health Serv.
PD NOV
PY 2016
VL 54
IS 11
BP 44
EP 53
DI 10.3928/02793695-20161026-01
PG 10
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA EJ2SF
UT WOS:000393060700014
PM 27805716
DA 2025-06-11
ER

PT J
AU Hall, KS
   Hoerster, KD
   Yancy, WS
AF Hall, Katherine S.
   Hoerster, Katherine D.
   Yancy, William S., Jr.
TI Post-Traumatic Stress Disorder, Physical Activity, and Eating Behaviors
SO EPIDEMIOLOGIC REVIEWS
LA English
DT Article
DE binge eating; diet; exercise; health outcomes; health promotion;
   nutrition; prevention; PTSD
ID MENTAL-HEALTH; SEDENTARY TIME; PSYCHIATRIC-DISORDERS; SMOKING-CESSATION;
   VIETNAM VETERANS; NATIONAL SAMPLE; EXERCISE; PTSD; ASSOCIATION;
   DEPRESSION
AB Post-traumatic stress disorder (PTSD), a prevalent and costly psychiatric disorder, is associated with high rates of obesity and cardiometabolic diseases. Many studies have examined PTSD and risky behaviors (e.g., smoking, alcohol/substance abuse); far fewer have examined the relationship between PTSD and health-promoting behaviors. Physical activity and eating behaviors are 2 lifestyle factors that impact cardiometabolic risk and long-term health. This comprehensive review of the literature (1980-2014) examined studies that reported physical activity and eating behaviors in adults with PTSD or PTSD symptoms. A systematic search of electronic databases identified 15 articles on PTSD-physical activity and 10 articles on PTSD-eating behaviors in adults. These studies suggest that there may be a negative association among PTSD, physical activity, and eating behaviors. Preliminary evidence from 3 pilot intervention studies suggests that changes in physical activity or diet may have beneficial effects on PTSD symptoms. There was considerable heterogeneity in the study designs and sample populations, and many of the studies had methodological and reporting limitations. More evidence in representative samples, using multivariable analytical techniques, is needed to identify a definitive relationship between PTSD and these health behaviors. Intervention studies for PTSD that examine secondary effects on physical activity/eating behaviors, as well as interventions to change physical activity/eating behaviors that examine change in PTSD, are also of interest.
C1 [Hall, Katherine S.] Vet Affairs Med Ctr, Geriatr Res Educ & Clin Ctr GRECC 182, Durham, NC 27705 USA.
C3 US Department of Veterans Affairs; Veterans Health Administration (VHA);
   Geriatric Research Education & Clinical Center
RP Hall, KS (corresponding author), Vet Affairs Med Ctr, Geriatr Res Educ & Clin Ctr GRECC 182, 508 Fulton St, Durham, NC 27705 USA.
EM katherine.hall@duke.edu
FU Department of Veterans Affairs [RRD-E782MM]
FX Dr. Katherine S. Hall is supported by Career Development Award
   RRD-E782MM from the Department of Veterans Affairs.
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   Wilmot EG, 2012, DIABETOLOGIA, V55, P2895, DOI 10.1007/s00125-012-2677-z
   Zen AL, 2012, HEALTH PSYCHOL, V31, P194, DOI 10.1037/a0025989
NR 80
TC 108
Z9 126
U1 0
U2 54
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0193-936X
EI 1478-6729
J9 EPIDEMIOL REV
JI Epidemiol. Rev.
PY 2015
VL 37
IS 1
BP 103
EP 115
DI 10.1093/epirev/mxu011
PG 13
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA CL3ZX
UT WOS:000356892800008
PM 25595169
OA hybrid
DA 2025-06-11
ER

PT J
AU Whiteman, K
   Ruggiano, N
   Thomlison, B
AF Whiteman, Karen
   Ruggiano, Nicole
   Thomlison, Barbara
TI Transforming mental health services to address gender disparities in
   depression risk factors
SO JOURNAL OF WOMEN & AGING
LA English
DT Article
DE Depression; older adults; women
ID STRESSFUL LIFE EVENTS; 3RD NATIONAL-HEALTH; METABOLIC SYNDROME; MAJOR
   DEPRESSION; AGE-DIFFERENCES; UNITED-STATES; GERIATRIC DEPRESSION;
   PHYSICAL HEALTH; SEX-DIFFERENCES; OLDER WOMEN
AB Depression in older women is a significant and growing problem. Women who experience life stressors across the life span are at higher risk for developing depression than their male counterparts. Research has focused primarily on identifying and reducing the symptoms of depression for the general aging population, disregarding gender-specific differences in the foundational causes of depression. This article examines how women's unique experiences influence the development of depression and highlights how the current mental health system could better meet older women's needs by moving from a gender-neutral model to one that emphasizes women's experiences.
C1 [Whiteman, Karen; Ruggiano, Nicole; Thomlison, Barbara] Florida Atlantic Univ, Sch Social Work, 777 Glades Blvd, Boca Raton, FL 33431 USA.
C3 State University System of Florida; Florida Atlantic University
RP Whiteman, K (corresponding author), Florida Atlantic Univ, Sch Social Work, 777 Glades Blvd, Boca Raton, FL 33431 USA.
EM karen@researchgerontology.com
OI Fortuna, Karen/0000-0003-0343-2346; Ruggiano, Nicole/0000-0002-2398-7077
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NR 78
TC 10
Z9 13
U1 4
U2 31
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 0895-2841
EI 1540-7322
J9 J WOMEN AGING
JI J. Women Aging
PD NOV-DEC
PY 2016
VL 28
IS 6
BP 521
EP 529
DI 10.1080/08952841.2015.1072027
PG 9
WC Gerontology; Women's Studies
WE Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology; Women's Studies
GA EA5AW
UT WOS:000386630000007
PM 27391089
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Bennett, KK
   Buchanan, DM
   Jones, PG
   Spertus, JA
AF Bennett, Kymberley K.
   Buchanan, Donna M.
   Jones, Philip G.
   Spertus, John A.
TI Socioeconomic status, cognitive-emotional factors, and health status
   following myocardial infarction: testing the Reserve Capacity Model
SO JOURNAL OF BEHAVIORAL MEDICINE
LA English
DT Article
DE Socioeconomic status; Health status disparities; Myocardial infarction;
   Depressive symptoms; Cognitive-emotional factors
ID QUALITY-OF-LIFE; PSYCHOLOGICAL PERSPECTIVES; PSYCHOSOCIAL RESOURCES;
   METABOLIC SYNDROME; SOCIAL SUPPORT; HEART-DISEASE; WORK STRESS;
   ASSOCIATION; DEPRESSION; OPTIMISM
AB Health disparities by socioeconomic status (SES) exist for many outcomes, including patients' subjective health status after myocardial infarction (MI). The Reserve Capacity Model (RCM), a theoretical means to understand such disparities, was tested to examine the possible mediating effects of cognitive-emotional factors on the association between SES and health status. Data from 2,348 post-MI patients in PREMIER were used. Indicators of SES were collected during hospitalization via personal interviews, while participants completed measures of stress and reserves at 1 month, depressive symptoms at 6 months, and health status at 1 year through telephone interviews. Structural equation model results provide partial support for the RCM, as cognitive-emotional factors partially mediated the association between SES and mental health status. For physical health status, results supported direct rather than indirect effects of SES. Findings suggest psychosocial interventions with patients of low SES will have their greatest effects on appraisals of psychological health status.
C1 [Bennett, Kymberley K.] Univ Missouri, Dept Psychol, Kansas City, MO 64110 USA.
   [Buchanan, Donna M.; Spertus, John A.] Univ Missouri, St Lukes Mid Amer Heart Inst, Dept Biomed & Hlth Informat, Kansas City, MO 64110 USA.
   [Jones, Philip G.] St Lukes Mid Amer Heart Inst, BLANK, Kansas City, MO USA.
   [Spertus, John A.] Univ Missouri, St Lukes Mid Amer Heart Inst, Dept Internal Med, Kansas City, MO 64110 USA.
C3 University of Missouri System; University of Missouri Kansas City;
   University of Missouri System; University of Missouri Kansas City; Saint
   Luke's Mid America Heart Institute; Saint Luke's Mid America Heart
   Institute; University of Missouri System; University of Missouri Kansas
   City; Saint Luke's Mid America Heart Institute
RP Bennett, KK (corresponding author), Univ Missouri, Dept Psychol, Cherry Hall,Room 302, Kansas City, MO 64110 USA.
EM bennettkk@umkc.edu
RI Spertus, John/ABD-3075-2021
OI Spertus, John/0000-0002-2839-2611
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NR 51
TC 12
Z9 13
U1 0
U2 10
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0160-7715
EI 1573-3521
J9 J BEHAV MED
JI J. Behav. Med.
PD FEB
PY 2015
VL 38
IS 1
BP 110
EP 121
DI 10.1007/s10865-014-9583-4
PG 12
WC Psychology, Clinical
WE Social Science Citation Index (SSCI)
SC Psychology
GA AZ4JM
UT WOS:000348187300012
PM 25022863
DA 2025-06-11
ER

PT J
AU Robins, JLW
   McCain, NL
   Elswick, RK
AF Robins, Jo Lynne W.
   McCain, Nancy L.
   Elswick, R. K., Jr.
TI Exploring the Complexity of Cardiometabolic Risk in Women
SO BIOLOGICAL RESEARCH FOR NURSING
LA English
DT Article
DE cardiovascular disease; women's health; cardiometabolic risk
ID CORONARY-ARTERY-DISEASE; VASCULAR ENDOTHELIAL-CELLS;
   CONGESTIVE-HEART-FAILURE; C-REACTIVE PROTEIN; METABOLIC SYNDROME;
   VITAMIN-D; CARDIOVASCULAR-DISEASE; INSULIN-RESISTANCE; SOCIAL SUPPORT;
   SALIVARY CORTISOL
AB Cardiovascular disease (CVD) is the leading cause of death in the United States. Women are more likely than men to present with advanced disease and experience higher CVD-related morbidity and mortality. Metabolic syndrome is a constellation of risk factors for Type 2 diabetes mellitus (T2DM) and CVD. Abdominal adiposity, a component of metabolic syndrome, is associated with insulin resistance and promotes an atherogenic inflammatory milieu. Cardiometabolic risk (CMR) encompasses metabolic syndrome and incorporates other risk factors such as lifestyle choices, gender, and genetics as risk factors for CVD yet still does not include more recently recognized physiological risk factors such as vitamin D deficiency or psychosocial risk factors such as perceived stress and lack of social support. Because a more comprehensive view of CVD risk factors may facilitate earlier identification and risk reduction, we undertook this exploratory pilot study to answer the question, How do healthy women with and without abdominal adiposity differ physiologically and psychosocially?. We recruited a total of 41 women for a single study visit and assessed a battery of baseline physiological and psychological measures. While the women in this study were free of any diagnoses associated with increased CMR, women with increased waist circumference (WC) exhibited significantly altered levels of several measures associated with impending CMR including insulin sensitivity, lipids, and adiponectin as well as lower social support. These findings suggest that a more comprehensive conceptualization of and refinement of measures for CMR may be useful for identifying and reducing CMR and ultimately CVD in women.
C1 [Robins, Jo Lynne W.; McCain, Nancy L.; Elswick, R. K., Jr.] Virginia Commonwealth Univ, Sch Nursing, Richmond, VA 23298 USA.
C3 Virginia Commonwealth University
RP Robins, JLW (corresponding author), Virginia Commonwealth Univ, Sch Nursing, POB 980567, Richmond, VA 23298 USA.
EM jwrobins@vcu.edu
FU National Institute of Nursing Research, National Institutes of Health
   [P20 NR008988]
FX The authors disclosed receipt of the following financial support for the
   research, authorship, and/or publication of this article: Funding
   provided by National Institute of Nursing Research, National Institutes
   of Health (P20 NR008988).
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NR 78
TC 8
Z9 10
U1 0
U2 9
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1099-8004
EI 1552-4175
J9 BIOL RES NURS
JI Biol. Res. Nurs.
PD APR
PY 2012
VL 14
IS 2
BP 160
EP 170
DI 10.1177/1099800411398652
PG 11
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA 930HL
UT WOS:000303128200007
PM 21406504
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Gancheva, S
   Caspari, D
   Bierwagen, A
   Jelenik, T
   Caprio, S
   Santoro, N
   Rothe, M
   Markgraf, DF
   Herebian, D
   Hwang, JH
   Öner-Sieben, S
   Mennenga, J
   Pacini, G
   Thimm, E
   Schlune, A
   Meissner, T
   vom Dahl, S
   Klee, D
   Mayatepek, E
   Roden, M
   Ensenauer, R
AF Gancheva, Sofiya
   Caspari, Daria
   Bierwagen, Alessandra
   Jelenik, Tomas
   Caprio, Sonia
   Santoro, Nicola
   Rothe, Maik
   Markgraf, Daniel F.
   Herebian, Diran
   Hwang, Jong-Hee
   Oener-Sieben, Soner
   Mennenga, Jasmin
   Pacini, Giovanni
   Thimm, Eva
   Schlune, Andrea
   Meissner, Thomas
   vom Dahl, Stephan
   Klee, Dirk
   Mayatepek, Ertan
   Roden, Michael
   Ensenauer, Regina
TI Cardiometabolic risk factor clustering in patients with deficient
   branched-chain amino acid catabolism: A case-control study
SO JOURNAL OF INHERITED METABOLIC DISEASE
LA English
DT Article
DE cardiometabolic; fatty liver; metabolic syndrome; mitochondria; organic
   acidemia; oxidative stress
ID PROPIONIC ACIDEMIA; METABOLIC SYNDROME; PHENOTYPIC SPECTRUM; ISOVALERIC
   ACIDEMIA; METHYLMALONIC ACID; ORGANIC ACIDURIAS; OXIDATIVE DAMAGE;
   SKELETAL-MUSCLE; CHILDREN; INSULIN
AB Classical organic acidemias (OAs) result from defective mitochondrial catabolism of branched-chain amino acids (BCAAs). Abnormal mitochondrial function relates to oxidative stress, ectopic lipids and insulin resistance (IR). We investigated whether genetically impaired function of mitochondrial BCAA catabolism associates with cardiometabolic risk factors, altered liver and muscle energy metabolism, and IR. In this case-control study, 31 children and young adults with propionic acidemia (PA), methylmalonic acidemia (MMA) or isovaleric acidemia (IVA) were compared with 30 healthy young humans using comprehensive metabolic phenotyping including in vivo(31)P/H-1 magnetic resonance spectroscopy of liver and skeletal muscle. Among all OAs, patients with PA exhibited abdominal adiposity, IR, fasting hyperglycaemia and hypertriglyceridemia as well as increased liver fat accumulation, despite dietary energy intake within recommendations for age and sex. In contrast, patients with MMA more frequently featured higher energy intake than recommended and had a different phenotype including hepatomegaly and mildly lower skeletal muscle ATP content. In skeletal muscle of patients with PA, slightly lower inorganic phosphate levels were found. However, hepatic ATP and inorganic phosphate concentrations were not different between all OA patients and controls. In patients with IVA, no abnormalities were detected. Impaired BCAA catabolism in PA, but not in MMA or IVA, was associated with a previously unrecognised, metabolic syndrome-like phenotype with abdominal adiposity potentially resulting from ectopic lipid storage. These findings suggest the need for early cardiometabolic risk factor screening in PA.
C1 [Gancheva, Sofiya; Roden, Michael] Heinrich Heine Univ Dusseldorf, Fac Med, Div Endocrinol & Diabetol, Dusseldorf, Germany.
   [Gancheva, Sofiya; Bierwagen, Alessandra; Jelenik, Tomas; Rothe, Maik; Markgraf, Daniel F.; Hwang, Jong-Hee; Roden, Michael] Heinrich Heine Univ Dusseldorf, Inst Clin Diabetol, Leibniz Inst Diabet Res, German Diabet Ctr, Dusseldorf, Germany.
   [Gancheva, Sofiya; Bierwagen, Alessandra; Jelenik, Tomas; Rothe, Maik; Markgraf, Daniel F.; Hwang, Jong-Hee; Roden, Michael] German Ctr Diabet Res DZD eV, Munich, Germany.
   [Caspari, Daria; Herebian, Diran; Oener-Sieben, Soner; Mennenga, Jasmin; Thimm, Eva; Schlune, Andrea; Meissner, Thomas; Mayatepek, Ertan; Ensenauer, Regina] Heinrich Heine Univ Dusseldorf, Univ Childrens Hosp, Fac Med, Dept Gen Pediat Neonatol & Pediat Cardiol, Moorenstr 5, D-40225 Dusseldorf, Germany.
   [Caprio, Sonia; Santoro, Nicola] Yale Univ, Sch Med, Dept Pediat, Magnet Resonance Res Ctr, New Haven, CT 06510 USA.
   [Santoro, Nicola] V Tiberio Univ Molise Via Sanctis, Dept Med & Hlth Sci, Campobasso, Italy.
   [Pacini, Giovanni] CNR Inst Neurosci, Metab Unit, Padua, Italy.
   [vom Dahl, Stephan] Heinrich Heine Univ Dusseldorf, Fac Med, Div Gastroenterol Hepatol & Infect Dis, Dusseldorf, Germany.
   [Klee, Dirk] Heinrich Heine Univ Dusseldorf, Fac Med, Dept Diagnost & Intervent Radiol, Dusseldorf, Germany.
   [Ensenauer, Regina] Max Rubner Inst, Inst Child Nutr, Karlsruhe, Germany.
C3 Heinrich Heine University Dusseldorf; Heinrich Heine University
   Dusseldorf; Leibniz Association; Deutsches Diabetes-Zentrum (DDZ);
   German Center for Diabetes Research (DZD); Heinrich Heine University
   Dusseldorf; Yale University; Consiglio Nazionale delle Ricerche (CNR);
   Istituto di Neuroscienze (IN-CNR); Heinrich Heine University Dusseldorf;
   Heinrich Heine University Dusseldorf
RP Ensenauer, R (corresponding author), Heinrich Heine Univ Dusseldorf, Univ Childrens Hosp, Fac Med, Dept Gen Pediat Neonatol & Pediat Cardiol, Moorenstr 5, D-40225 Dusseldorf, Germany.; Roden, M (corresponding author), Heinrich Heine Univ, Div Endocrinol & Diabetol, Fac Med, Aufm Hennekamp 62, D-40225 Dusseldorf, Germany.
EM michael.roden@ddz.de; regina.ensenauer@med.uni-duesseldorf.de
RI Roden, Michael/AAD-3843-2019; Bierwagen, Alessandra/T-6163-2017;
   Santoro, Nicola/A-4897-2014; Schlune, Andrea/KMA-2010-2024; vom Dahl,
   Stephan/AAF-8456-2021; Herebian, Diran/A-1440-2017; Oner-Sieben,
   Soner/AAA-5967-2021
OI Oner-Sieben, Soner/0000-0002-1398-2643; Dr. Herebian,
   Diran/0000-0002-8528-0122; Rothe, Maik/0009-0001-8533-7520; Gancheva,
   Sofiya/0009-0006-0401-7776
FU y
FX Part of this work is the basis for the doctoral thesis of Daria Caspari.
   The authors would like to thank Nora Schmitz, Tjark Engelhardt, Kateryna
   Fuks, Delphina Gomes, Thi Thu Thuy Nguyen and Anne-Kathrin Neugebauer
   from the Department of General Pediatrics, Neonatology, and Pediatric
   Cardiology, University Children's Hospital Dusseldorf, and Kai Tinnes,
   Myrko Esser and Andrea Nagel from the Institute for Clinical
   Diabetology, German Diabetes Center Dusseldorf for their excellent help
   with the experiments. The work of MR and SG was funded by a grant to the
   German Diabetes Center (DDZ) from the German Federal Ministry of Health
   and the Ministry of Culture and Science of the state North
   Rhine-Westphalia. M.R. also received funding by the German Center for
   Diabetes Research (DZD e.V.) from the German Federal Ministry of
   Education and Research (BMBF) and by the European Funds for Regional
   Development (EFRE-0400191). This study was supported in part by a grant
   of the Association of the Rhine-Westphalia paediatricians and paediatric
   surgeons.
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NR 62
TC 5
Z9 5
U1 0
U2 3
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0141-8955
EI 1573-2665
J9 J INHERIT METAB DIS
JI J. Inherit. Metab. Dis.
PD SEP
PY 2020
VL 43
IS 5
BP 981
EP 993
DI 10.1002/jimd.12231
PG 13
WC Endocrinology & Metabolism; Genetics & Heredity; Medicine, Research &
   Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Genetics & Heredity; Research & Experimental
   Medicine
GA NW7AS
UT WOS:000575169600011
PM 32118306
OA hybrid
DA 2025-06-11
ER

PT J
AU Janczura, M
   Dropinski, J
   Gielicz, A
   Kotula-Horowitz, K
   Iwaniec, T
   Stanisz, A
   Rosa, R
   Domagala, TB
AF Janczura, Miroslaw
   Dropinski, Jerzy
   Gielicz, Anna
   Kotula-Horowitz, Katarzyna
   Iwaniec, Teresa
   Stanisz, Andrzej
   Rosa, Rafal
   Domagala, Teresa B.
TI Potential roles of psychological and oxidative stress in insulin
   resistance: a cohort-based study
SO DIABETOLOGY & METABOLIC SYNDROME
LA English
DT Article
DE Insulin resistance; Psychological stress; Cortisol; Oxidative stress
ID PERCEIVED STRESS; CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; IN-VIVO;
   CORTISOL; RISK; ASSOCIATION; OBESITY; INFLAMMATION; MECHANISMS
AB Background The present study investigated the relationships between psychological stress indices and oxidative stress marker, also when combined with emergent insulin resistance (IR), in the non-diabetic, middle-aged subjects, exposed to frequent/chronic psychological stressors. Methods Cross-sectional data from a cohort of non-diabetic police officers (n = 234; 19F), aged 27-56 years, were used. Plasma inflammatory (CRP, TNF-alpha), oxidative stress (free 8-iso-prostaglandin F-2 alpha; 8-iso-PGF(2 alpha)) markers, and insulin were measured. The value of homeostasis model assessment of IR index (HOMA-IR) was assumed the threshold value of IR, i.e. 2.04. Free cortisol in urine and perceived stress (psychological stress indices) were also measured. Results In the IR subjects, most biochemical variables, inflammatory markers and urine cortisol were significantly higher, as compared to the non-IR ones. Psychological stress indices were associated with plasma 8-iso-PGF(2 alpha)[B = 0.139, 95% CI (0.048, 0.230), p = 0.002, and B = 0.007, 95% CI (0.0006, 0.014), p = 0.03; for perceived stress level and cortisol, respectively]. Positive associations were established between plasma 8-iso-PGF(2 alpha)[B = 0.069, 95% CI (0.016-0.120), p = 0.01] and urine cortisol [B = 0.003, 95% CI (0.0003, 0.005), p = 0.02] with HOMA-IR. Metabolic syndrome, as defined by IDF criteria, was established in 110 study subjects, whereas 136 of them were hypertensive. Waist circumference [B = 0.056, 95% CI (0.039, 0.074), p < 0.0001], and systolic blood pressure [B = 0.009, 95% CI (0.00003, 0.018), p = 0.04] were positively associated with HOMA-IR, whereas the association of HDL cholesterol [B = - 0.597, 95% CI (- 1.139, - 0.055), p = 0.03] was a negative one. Cortisol [OR = 1.007, 95% CI (1.002, 1.012), p = 0.006], and 8-iso-PGF(2 alpha)[OR = 1.103, 95% CI (1.010, 1.201), p = 0.02] affected the incidence of IR. After adjustment for metabolic syndrome (or its components), age, sex, and current smoking, the effects became non-significant. Out of metabolic syndrome components, waist circumference [OR 4.966, 95% CI (2.29, 10.751), p = 0.00004] and hypertriglyceridemia [OR 1.993, 95% CI (1.063, 3.736), p = 0.03] increased the chance of IR incidence. Conclusions Both psychological stress indices were associated with oxidative stress, but only cortisol with HOMA-IR. In the subjects exposed to frequent/chronic psychological stressors, cortisol and oxidative stress marker affected IR incidence, being statistically attenuated, though, following adjustment for metabolic syndrome, or its components.
C1 [Janczura, Miroslaw] Jagiellonian Univ, Fac Hlth Sci, Sch Med, Krakow, Poland.
   [Dropinski, Jerzy; Gielicz, Anna; Iwaniec, Teresa] Jagiellonian Univ, Dept Internal Med, Sch Med, Krakow, Poland.
   [Kotula-Horowitz, Katarzyna] Minist Interior & Adm, Dept Internal Med, Hlth Care Ctr, Krakow, Poland.
   [Stanisz, Andrzej] Jagiellonian Univ, Sch Med, Dept Bioinformat & Telemed, Krakow, Poland.
   [Rosa, Rafal] Minist Interior & Adm, Dept Anesthesiol & Intens Care, Hlth Care Ctr, Krakow, Poland.
   [Domagala, Teresa B.] Jagiellonian Univ, Dept Med Biochem, Sch Med, PL-31034 Krakow, Poland.
C3 Jagiellonian University; Jagiellonian University; Jagiellonian
   University; Jagiellonian University
RP Domagala, TB (corresponding author), Jagiellonian Univ, Dept Med Biochem, Sch Med, PL-31034 Krakow, Poland.
EM domagala32@yahoo.com
RI Janczura, Miroslaw/HSE-9726-2023; Gielicz, Anna/MTC-4051-2025
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NR 48
TC 7
Z9 9
U1 0
U2 1
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1758-5996
J9 DIABETOL METAB SYNDR
JI Diabetol. Metab. Syndr.
PD JUL 8
PY 2020
VL 12
IS 1
AR 58
DI 10.1186/s13098-020-00566-8
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA MO9AK
UT WOS:000551808900001
PM 32670417
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU van Heijningen, CJM
   van Berkel, SR
   Rosinda, SJ
   Penninx, BWJH
   Alink, LRA
   Elzinga, BM
AF van Heijningen, Carline J. M.
   van Berkel, Sheila R.
   Rosinda, Selena J.
   Penninx, Brenda W. J. H.
   Alink, Lenneke R. A.
   Elzinga, Bernet M.
TI Long-term effects of experiencing childhood parental death on mental and
   physical health: A NESDA study
SO STRESS AND HEALTH
LA English
DT Article
DE childhood parental death; long-term health outcomes; NESDA
ID METABOLIC SYNDROME; DEPRESSIVE SYMPTOMATOLOGY; MAJOR DEPRESSION;
   TELOMERE LENGTH; RISK BEHAVIORS; USE DISORDERS; LIFE STRESS; ANXIETY;
   ASSOCIATION; SUICIDE
AB Experiencing parental death during childhood is an adverse, potentially traumatic experience that may have substantial long-term effects on mental and physical well-being. The current study was based on data of the Netherlands Study of Depression and Anxiety to investigate mental health (i.e., depressive symptoms, anxiety symptoms, and suicidal ideation) and physical health outcomes (i.e., metabolic syndrome, telomere length, and perceived physical health) as well as health behaviour (i.e., smoking status, alcohol use, and physical activity) to provide more insight into the long-term outcomes after experiencing childhood parental death (CPD). For individuals who experienced CPD, we also investigated the role of loss-related factors in these associations, namely the age of the child when their parent passed away and gender of the deceased parent. Interviews and questionnaires were completed by adults between 18 and 65 years; 177 participants experienced CPD (mean age = 45.19, 61.6% female) and 2463 did not (mean age = 41.38, 66.6% female). Results showed no overall association between the experience of CPD and mental and physical health indices and health behaviour. Within the CPD group, experiencing CPD at a younger age was related to a higher likelihood of suicidal ideation. These findings seem to illustrate a general positive adjustment with regard to long-term health functioning after experiencing such an impactful life event. Future research should focus on individual differences in terms of adaptation, especially elucidating on contextual factors after the loss, such as the kind of support that is or is not provided by the surviving parent and/or other important individuals.
C1 [van Heijningen, Carline J. M.; van Berkel, Sheila R.; Rosinda, Selena J.; Alink, Lenneke R. A.] Leiden Univ, Inst Educ & Child Studies, Leiden, Netherlands.
   [Penninx, Brenda W. J. H.] Vrije Univ, Amsterdam Univ Med Ctr, Amsterdam Publ Hlth, Dept Psychiat, Amsterdam, Netherlands.
   [Alink, Lenneke R. A.; Elzinga, Bernet M.] Leiden Univ, Leiden Inst Brain & Cognit LIBC, Leiden, Netherlands.
   [Elzinga, Bernet M.] Leiden Univ, Inst Psychol, Clin Psychol Unit, Leiden, Netherlands.
C3 Leiden University; Leiden University - Excl LUMC; Vrije Universiteit
   Amsterdam; Leiden University - Excl LUMC; Leiden University; Leiden
   University - Excl LUMC; Leiden University
RP van Heijningen, CJM (corresponding author), Leiden Univ, Inst Educ & Child Studies, Leiden, Netherlands.
EM c.j.m.van.heijningen@fsw.leidenuniv.nl
RI Alink, Lenneke/AAX-2186-2021; Penninx, Brenda/S-7627-2017; Van Berkel,
   Sheila/KZG-9436-2024
OI van Heijningen, Carline/0000-0003-1903-3278
FU The infrastructure for the NESDA study () has been funded through the
   Geestkracht program of the Netherlands Organisation for Health Research
   and Development (ZonMw, grant number 10-000-1002) and by participating
   universities and mental health care organis [10-000-1002]; Geestkracht
   program of the Netherlands Organisation for Health Research and
   Development (ZonMw); GGZ inGeest; Dimence [W18602-5-103]; Leiden
   University Fund
FX The infrastructure for the NESDA study () has been funded through the
   Geestkracht program of the Netherlands Organisation for Health Research
   and Development (ZonMw, grant number 10-000-1002) and by participating
   universities and mental health care organisations (Amsterdam University
   Medical Centers [location VUmc], GGZ inGeest, Leiden University Medical
   Center, University Medical Center Groningen, University of Groningen,
   Dimence, Lentis, GGZ Friesland, GGZ Drenthe, Rob Giel Onderzoekcentrum).
   The writing of this article was supported by the Leiden University Fund
   (LUF; Leo Moret Fonds grant number W18602-5-103) through a grant awarded
   to prof. dr. Lenneke R. A. Alink. We would like to thank Harold Nefs for
   statistical consultation.
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NR 79
TC 3
Z9 3
U1 8
U2 20
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1532-3005
EI 1532-2998
J9 STRESS HEALTH
JI Stress Health
PD JUN
PY 2024
VL 40
IS 3
DI 10.1002/smi.3322
EA OCT 2023
PG 14
WC Psychology, Applied; Psychiatry; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA TY5L5
UT WOS:001086468700001
PM 37830435
OA hybrid
DA 2025-06-11
ER

PT J
AU Canhada, SL
   Vigo, A
   Giatti, L
   Fonseca, MD
   Lopes, LJ
   Cardoso, LD
   Monteiro, CA
   Schmidt, MI
   Duncan, BB
AF Canhada, Scheine Leite
   Vigo, Alvaro
   Giatti, Luana
   Fonseca, Maria de Jesus
   Lopes, Leidjaira Juvanhol
   Cardoso, Leticia de Oliveira
   Monteiro, Carlos Augusto
   Schmidt, Maria Ines
   Duncan, Bruce Bartholow
TI Associations of Ultra-Processed Food Intake with the Incidence of
   Cardiometabolic and Mental Health Outcomes Go Beyond Specific
   Subgroups-The Brazilian Longitudinal Study of Adult Health
SO NUTRIENTS
LA English
DT Article
DE foods; sugar-sweetened beverages; processed meat; weight gain;
   cardiometabolic risk factors; epidemiology; mental disorders
ID STATEMENT; MORTALITY
AB Background/Objectives: Avoidance of ultra-processed foods (UPFs) has been recommended to achieve a healthy diet, but whether it applies equally to all UPFs is uncertain. We evaluated individual UPF subgroups in the prediction of cardiometabolic and mental health outcomes. Methods: The Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) is an occupational cohort study of 15,105 adults (35-74 years) recruited in 2008-2010. We followed participants up to 2018 to ascertain elevated weight and waist gains and the onset of metabolic syndrome, hypertension, metabolic dysfunction-associated steatotic liver disease, diabetes, common mental disorders, depressive episodes, and anxiety disorders. Results: In adjusted robust Poisson regression, greater overall UPF intake at the baseline predicted all studied outcomes. Various subgroups of UPF, most frequently processed meat and sweetened beverages, individually conferred a greater risk, and nearly all predicted at least one studied outcome. Considering all subgroups and outcomes, a broad pattern of overall risk was present. When subgroups not individually predictive of these outcomes were aggregated, increased risk (for a one-standard deviation change) was observed for elevated weight (RR = 1.05; 95% CI 1.01-1.11) and waist (RR = 1.05; 95% CI 1.00-1.10) gains, and for the incidence of common mental (RR = 1.06; 95% CI 1.01-1.12), and anxiety (RR = 1.09; 95% CI 1.02-1.16) disorders. Conclusions: UPFs overall and their subgroups predicted future cardiometabolic and mental health outcomes. The pattern of individual UPF subgroup associations varied across outcomes, and the aggregate of subgroups not individually predicting risk also predicted large gains in overall and central adiposity and the incidence of mental health disorders. While additional studies investigating other outcomes are needed, these findings justify avoidance of overall UPF intake in health promotion and disease prevention.
C1 [Canhada, Scheine Leite; Vigo, Alvaro; Schmidt, Maria Ines; Duncan, Bruce Bartholow] Univ Fed Rio Grande do Sul, Postgrad Program Epidemiol, BR-90035003 Porto Alegre, RS, Brazil.
   [Giatti, Luana] Univ Fed Minas Gerais, Sch Med, Dept Prevent & Social Med, BR-30130100 Belo Horizonte, MG, Brazil.
   [Giatti, Luana] Univ Fed Minas Gerais, Clin Hosp, EBSER, BR-30130100 Belo Horizonte, MG, Brazil.
   [Fonseca, Maria de Jesus; Lopes, Leidjaira Juvanhol; Cardoso, Leticia de Oliveira] Fundacao Oswaldo Cruz, Natl Sch Publ Hlth, BR-21040900 Rio De Janeiro, RJ, Brazil.
   [Monteiro, Carlos Augusto] Univ Sao Paulo, Ctr Epidemiol Studies Hlth & Nutr, Sch Publ Hlth, BR-05508220 Sao Paulo, SP, Brazil.
C3 Universidade Federal do Rio Grande do Sul; Universidade Federal de Minas
   Gerais; Universidade Federal de Minas Gerais; Fundacao Oswaldo Cruz;
   Universidade de Sao Paulo
RP Canhada, SL (corresponding author), Univ Fed Rio Grande do Sul, Postgrad Program Epidemiol, BR-90035003 Porto Alegre, RS, Brazil.
EM scheinelc@gmail.com
RI Vigo, Alvaro/S-2243-2019; Juvanhol, Leidjaira/AAW-5793-2020; Schmidt,
   Maria Inês/AGT-5691-2022; Monteiro, Carlos/F-9892-2012; Duncan,
   Bruce/L-4140-2016
OI Giatti, Luana/0000-0001-5454-2460; Monteiro, Carlos/0000-0002-3777-1533;
   Lopes Juvanhol, Leidjaira/0000-0001-8012-6006; CANHADA, SCHEINE
   LEITE/0000-0002-4324-9848; Duncan, Bruce/0000-0002-7491-2630
FU Brazilian Ministries of Health (Department of Science and Technology)
   and of Science, Technology, and Innovation; Brazilian Ministries of
   Health (Department of Science and Technology) [01 06 0010.00, 01 06
   0212.00, 01 06 0300.00, 01 06 0278.00, 01 06 0115.00, 01 06 0071.00];
   Science, Technology, and Innovation (Funding Authority for Studies and
   Projects-FINEP) [405551/2015-0, 405544/2015-4, 405547/2015-3,
   405552/2015-7, 405543/2015-8, 405545/2015-0]; National Council for
   Scientific and Technological Development (CNPq) [TED 95/2019]; Brazilian
   Ministry of Health [150805/2024-1]; Brazilian National Council for
   Scientific and Technological Development (CNPq); CNPq
FX This research received support from the Brazilian Ministries of Health
   (Department of Science and Technology) and of Science, Technology, and
   Innovation (Funding Authority for Studies and Projects-FINEP, grant
   numbers 01 06 0010.00, 01 06 0212.00, 01 06 0300.00, 01 06 0278.00, 01
   06 0115.00, 01 06 0071.00), and the National Council for Scientific and
   Technological Development (CNPq, grant numbers 405551/2015-0,
   405544/2015-4, 405547/2015-3, 405552/2015-7, 405543/2015-8,
   405545/2015-0). SLC received fellowships from the Brazilian Ministry of
   Health (TED 95/2019) and from the Brazilian National Council for
   Scientific and Technological Development (CNPq, grant number
   150805/2024-1). LG, MJF, AV, MIS and BBD received productivity in
   research fellowships from CNPq. Researchers were independent of the
   funders.
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NR 39
TC 2
Z9 2
U1 3
U2 3
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD DEC
PY 2024
VL 16
IS 24
AR 4291
DI 10.3390/nu16244291
PG 14
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA Q4M3S
UT WOS:001384439000001
PM 39770912
OA gold
DA 2025-06-11
ER

PT J
AU Vehmeijer, FOL
   Santos, S
   de Rijke, YB
   van den Akker, ELT
   Felix, JF
   van Rossum, EFC
   Jaddoe, VWV
AF Vehmeijer, Florianne O. L.
   Santos, Susana
   de Rijke, Yolanda B.
   van den Akker, Erica L. T.
   Felix, Janine F.
   van Rossum, Elisabeth F. C.
   Jaddoe, Vincent W. V.
TI Associations of Hair Cortisol Concentrations With Cardiometabolic Risk
   Factors in Childhood
SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Article
DE hair cortisol; child; cardiometabolic risk; blood pressure; heart rate;
   lipids; cholesterol; insulin; glucose; C-reactive protein
ID C-REACTIVE PROTEIN; METABOLIC SYNDROME; BLOOD-PRESSURE; CARDIOVASCULAR
   RISK; SERUM CORTISOL; CUSHINGS-SYNDROME; OBESE CHILDREN; GENERATION R;
   BODY-MASS; STRESS
AB Context: Biological stress is related to cardiovascular disease in adults.The associations of stress with cardiovascular and metabolic diseases may originate in childhood.
   Objective: This work aims to examine the associations of hair cortisol concentrations at age 6 years with cardiometabolic risk factors at ages 6 and 10 years.
   Methods: Cortisol concentrations were measured in hair of 6-year-old children (n = 2598) participating in the Generation R Study, a population-based prospective cohort study in Rotterdam, the Netherlands. Main outcome measures included blood pressure, heart rate, concentrations of insulin, glucose, lipids, and C-reactive protein in blood at ages 6 and 10 years.
   Results: Higher hair cortisol concentrations at age 6 years were associated with higher systolic blood pressure at age 10 years (difference 0.17 SD score; 95% CI, 0.03-0.31). The association attenuated into nonsignificance after adjustment for childhood body mass index (BMI) at age 6 years. Higher hair cortisol concentrations at age 6 years were associated with an increase in total and low-density lipoprotein cholesterol between ages 6 and 10 years but not with those measurements at age 6 or 10 years. Hair cortisol concentrations were not associated with other cardiometabolic risk factors at age 6 or 10 years.
   Conclusion: Hair cortisol concentrations were not independent of BMI associated with cardiometabolic risk factors at 6 or 10 years. The associations of biological stress with cardiometabolic risk factors may develop at later ages.
C1 [Vehmeijer, Florianne O. L.; Santos, Susana; Felix, Janine F.; Jaddoe, Vincent W. V.] Erasmus MC, Univ Med Ctr, Generat R Study Grp, NL-3000 CA Rotterdam, Netherlands.
   [Vehmeijer, Florianne O. L.; Santos, Susana; van den Akker, Erica L. T.; Felix, Janine F.; Jaddoe, Vincent W. V.] Erasmus MC, Univ Med Ctr, Dept Pediat, NL-3000 CA Rotterdam, Netherlands.
   [de Rijke, Yolanda B.] Erasmus MC, Univ Med Ctr, Dept Clin Chem, NL-3000 CA Rotterdam, Netherlands.
   [de Rijke, Yolanda B.; van den Akker, Erica L. T.; van Rossum, Elisabeth F. C.] Erasmus MC, Univ Med Ctr, Obes Ctr CGG, NL-3000 CA Rotterdam, Netherlands.
   [van Rossum, Elisabeth F. C.] Erasmus MC, Univ Med Ctr, Dept Internal Med, Div Endocrinol, NL-3000 CA Rotterdam, Netherlands.
C3 Erasmus University Rotterdam; Erasmus MC; Erasmus University Rotterdam;
   Erasmus MC; Erasmus University Rotterdam; Erasmus MC; Erasmus University
   Rotterdam; Erasmus MC; Erasmus University Rotterdam; Erasmus MC
RP Jaddoe, VWV (corresponding author), Erasmus MC, Na 29-08,POB 2040, NL-3000 CA Rotterdam, Netherlands.
EM v.jaddoe@erasmusmc.nl
RI van Rossum, Elisabeth/AAP-9388-2020; Saxena, Sonia/ABD-7737-2021; de
   Rijke, Yolanda/HLP-5779-2023
OI Vehmeijer, Florianne/0000-0002-1858-3430; van Rossum,
   Elisabeth/0000-0003-0120-4913; Jaddoe, Vincent/0000-0003-2939-0041;
   Santos, Susana/0000-0003-0613-3181
FU European Union's Horizon 2020 Research and Innovation Programme [848158,
   733206, 874739]; Erasmus Medical Center, University Medical Center,
   Rotterdam, the Netherlands; Organization for Health Research and
   Development (ZonMw); Netherlands Organization for Scientific Research
   (NWO); Ministry of Health, Welfare and Sport; Ministry of Youth and
   Families; European Research Council [ERC-2014CoG-648916]; Elisabeth
   Foundation; Vidi Grant from the Netherlands Organization of Scientific
   Research NWO [91716453]; H2020 Societal Challenges Programme [733206]
   Funding Source: H2020 Societal Challenges Programme
FX This work was supported by the European Union's Horizon 2020 Research
   and Innovation Programme (Nos. 848158, EarlyCause; 733206, LifeCycle;
   and 874739 LongITools). The general design of the Generation R Study is
   supported by the Erasmus Medical Center, University Medical Center,
   Rotterdam, the Netherlands; Organization for Health Research and
   Development (ZonMw); the Netherlands Organization for Scientific
   Research (NWO); the Ministry of Health, Welfare and Sport; and the
   Ministry of Youth and Families. Dr Jaddoe has received funding from the
   European Research Council (grant No. ERC-2014CoG-648916). Dr van den
   Akker and Dr van Rossum are supported by the Elisabeth Foundation. Dr
   van Rossum received a Vidi Grant (No. 91716453) from the Netherlands
   Organization of Scientific Research NWO.
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NR 59
TC 8
Z9 8
U1 0
U2 5
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0021-972X
EI 1945-7197
J9 J CLIN ENDOCR METAB
JI J. Clin. Endocrinol. Metab.
PD SEP
PY 2021
VL 106
IS 9
BP E3400
EP E3413
DI 10.1210/clinem/dgab379
EA MAY 2021
PG 14
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA UL4LZ
UT WOS:000692625700034
PM 34050761
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Malan, L
   Malan, NT
   Wissing, MP
   Seedat, YK
AF Malan, Leone
   Malan, Nicolaas T.
   Wissing, Maria P.
   Seedat, Yackoob K.
TI Coping with urbanization: A cardiometabolic risk? The THUSA study
SO BIOLOGICAL PSYCHOLOGY
LA English
DT Article
DE Africans; Coping; Urbanization; Metabolic syndrome; Fibrinogen
ID METABOLIC SYNDROME; HYPERTENSION; HEALTH; FIBRINOGEN; AFRICANS; OBESITY;
   STRESS; WOMEN
AB An assessment of specific coping styles in rural-urban Africans is done to evaluate its contribution as cardiometabolic risk factor. In total, 608 apparently healthy Africans were included in a cross-sectional comparative study from the North-West Province in South Africa. The adapted and translated COPE Questionnaire classified participants according to their responses into active (AC) or passive (PC) copers. Fasting resting metabolic syndrome (MS) indicators using the WHO definition (glucose, high density lipoproteins, waist/hip ratio, hypertension prevalence, and trigiyceride) and associated MS values, i.e. fibrinogen were obtained. The Finapres recorded resting blood pressure continuously. Co-variates for ail statistical analyses included age, body mass index (BMI) and lifestyle factors (alcohol consumption, smoking habits and physical activity). The only MS values prevalent in urbanized participants were higher hypertension prevalence rates and fibrinogen (women only) compared to their rural counterparts. Adding coping styles, it was mainly the urbanized AC participants that indicated higher MS values (hypertension prevalence, glucose and fibrinogen) when compared to their rural and PC counterparts. In conclusion, urbanization is associated with enhanced blood pressure and fibrinogen (women) values only. Coping as cardiometabolic risk is accentuated in the urbanized AC group, especially the men. The urbanized AC group with their higher blood pressure values and more MS indicators appears to have behaviorally an AC style but physiologically a dissociated AC style. (c) 2008 Elsevier B.V. All rights reserved.
C1 [Malan, Leone; Malan, Nicolaas T.] North West Univ, Sch Physiol Nutr & Consumer Sci, ZA-2520 Potchefstroom, South Africa.
   [Wissing, Maria P.] North West Univ, Sch Psychosocial Behav Sci, ZA-2520 Potchefstroom, South Africa.
   [Seedat, Yackoob K.] Univ Kwa Zulu, Nelson Mandela Sch Med, Renal Hypertens Unit, ZA-4001 Durban, South Africa.
C3 North West University - South Africa; North West University - South
   Africa; University of Kwazulu Natal
RP Malan, L (corresponding author), North West Univ, Sch Physiol Nutr & Consumer Sci, Potchefstroom Campus,Private Bag X6001, ZA-2520 Potchefstroom, South Africa.
EM leone.malan@nwu.ac.za
RI Malan, Leone/Q-8187-2019; Malan, Leone/D-7203-2014
OI Malan, Leone/0000-0003-3187-2410
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NR 43
TC 53
Z9 57
U1 0
U2 13
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0301-0511
EI 1873-6246
J9 BIOL PSYCHOL
JI Biol. Psychol.
PD DEC
PY 2008
VL 79
IS 3
BP 323
EP 328
DI 10.1016/j.biopsycho.2008.07.007
PG 6
WC Psychology, Biological; Behavioral Sciences; Psychology; Psychology,
   Experimental
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Behavioral Sciences
GA 377UD
UT WOS:000261275300006
PM 18760323
DA 2025-06-11
ER

PT J
AU Cekirdekci, EI
   Bugan, B
AF Cekirdekci, Elif Ijlal
   Bugan, Baris
TI Level of Anxiety and Depression in Cardiac Syndrome X
SO MEDICAL PRINCIPLES AND PRACTICE
LA English
DT Article
DE Anxiety; Cardiac syndrome X; Depression
ID CORONARY-ARTERY-DISEASE; QUALITY-OF-LIFE; CHEST-PAIN; ANGINA-PECTORIS;
   HEART-DISEASE; WOMEN; IMIPRAMINE; DISORDERS; SURVIVAL
AB Objective: Cardiac syndrome X (CSX) is defined as anginalike symptoms, abnormalities on stress testing, and normal epicardial coronary arteries on coronary angiography. The aim of this study was to determine the Hospital Anxiety and Depression scores of patients with CSX and to compare with healthy controls. Materials/Subjects and Methods: Patients undergoing coronary angiography between January 2015 and December 2016 because of clinical indications, including abnormal noninvasive test results were examined. Two hundred and 10 subjects (110 patients with CSX, 100 controls) were enrolled. Demographic characteristics including age, education level, marriage status, and history of stressful life events were recorded. The Turkish version of the Hospital Anxiety and Depression scale was evaluated in the study population. Results: Anxiety, depression, and total scores in the patients with CSX were significantly higher than those in the control group (p < 0.001, p < 0.003, p < 0.001, respectively). Among women, anxiety, depression, total scores, and stressful life events were significantly higher in the CSX group (p = 0.006, p = 0.015, p = 0.001, p < 0.001, respectively). Patients with lower educational status had higher anxiety scores (p = 0.03), stressful life events, and HAD-A > 10 were the only independent predictors of CSX in logistic regression analysis with comparable ORs 2.256 (95% CI 1.057-4.817, p = 0.03) and 2,399 (95% CI 1.248-4.613, p = 0.009) respectively. Conclusion: The results of our research suggest that patients with CSX have a high prevalence of stress and psychiatric disturbances. Interventions targeted toward improving the quality of life and to give psychological support may have the potential benefits especially for women and individuals with lower education. (c) 2018 The Author(s) Published by S. Karger AG, Basel
C1 [Cekirdekci, Elif Ijlal; Bugan, Baris] Dr Suat Gunsel Univ, Kyrenia Hosp, Dept Cardiol, Sehit Yahya Bakir St 10, Karakum, Kyrenia, Cyprus.
C3 University of Kyrenia
RP Cekirdekci, EI (corresponding author), Dr Suat Gunsel Univ, Kyrenia Hosp, Dept Cardiol, Sehit Yahya Bakir St 10, Karakum, Kyrenia, Cyprus.
EM elifcekirdekci@hotmail.com
RI Bugan, Baris/AED-9824-2022; Cekirdekci, Elif Ijlal/AAC-3711-2022
OI Bugan, Baris/0000-0002-7210-9537
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NR 28
TC 9
Z9 10
U1 0
U2 3
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1011-7571
EI 1423-0151
J9 MED PRIN PRACT
JI Med. Princ. Pract.
PY 2019
VL 28
IS 1
BP 82
EP 86
DI 10.1159/000495109
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA HT2GW
UT WOS:000464382200013
PM 30396178
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Boyle, MP
   Kolber, BJ
   Vogt, SK
   Wozniak, DF
   Muglia, LJ
AF Boyle, MP
   Kolber, BJ
   Vogt, SK
   Wozniak, DF
   Muglia, LJ
TI Forebrain glucocorticoid receptors modulate anxiety-associated locomotor
   activation and adrenal responsiveness
SO JOURNAL OF NEUROSCIENCE
LA English
DT Article
DE glucocorticoid receptor; HPA axis; anxiety; knock-out mice; behavior;
   forebrain
ID MINERALOCORTICOID-RECEPTORS; METABOLIC SYNDROME; HPA AXIS; DEPRESSION;
   PITUITARY; STRESS; BRAIN; NEUROENDOCRINE; CAPACITY; DISORDER
AB Stress potently modulates anxiety- and depression-related behaviors. In response to stressors, the hypothalamic-pituitary-adrenal (HPA) axis is activated, resulting in the release of glucocorticoids from the adrenal cortex. These hormones act peripherally to restore homeostasis but also feed back to the CNS to control the intensity and duration of the stress response. Glucocorticoids act in limbic areas of the CNS to mediate the psychological and behavioral effects of stress. In this study, we investigate the effect of forebrain-specific disruption of the glucocorticoid receptor (GR) on stress- and anxiety-related behaviors. We demonstrate that mice with disruption of forebrain GR show alterations in stress- induced locomotor activation in a number of anxiety- related behavioral paradigms. These changes are associated with alterations in stress- induced HPA axis activation and, importantly, are not attenuated by chronic treatment with the tricyclic antidepressant imipramine. These data demonstrate the importance of forebrain GR in regulation of physiological and behavioral stress reactivity and suggest that distinct pathways regulate despair- and anxiety-related behaviors.
C1 Washington Univ, Sch Med, Dept Pediat, St Louis, MO 63110 USA.
   Washington Univ, Sch Med, Dept Mol Biol & Pharmacol, St Louis, MO 63110 USA.
   Washington Univ, Sch Med, Dept Psychiat, St Louis, MO 63110 USA.
C3 Washington University (WUSTL); Washington University (WUSTL); Washington
   University (WUSTL)
RP Washington Univ, Sch Med, Dept Pediat, 660 S Euclid Ave,Box 8208, St Louis, MO 63110 USA.
EM muglia_l@kids.wustl.edu
OI Kolber, Benedict/0000-0001-8665-1805
FU NIA NIH HHS [AG18876] Funding Source: Medline; NIMH NIH HHS
   [MH067374-02] Funding Source: Medline
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NR 26
TC 136
Z9 170
U1 1
U2 17
PU SOC NEUROSCIENCE
PI WASHINGTON
PA 11 DUPONT CIRCLE, NW, STE 500, WASHINGTON, DC 20036 USA
SN 0270-6474
EI 1529-2401
J9 J NEUROSCI
JI J. Neurosci.
PD FEB 15
PY 2006
VL 26
IS 7
BP 1971
EP 1978
DI 10.1523/JNEUROSCI.2173-05.2006
PG 8
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 012LT
UT WOS:000235341400012
PM 16481429
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Van Gaal, LF
   Scheen, AJ
   Rissanen, AM
   Roessner, S
   Hanotin, C
   Ziegler, O
AF Van Gaal, Luc F.
   Scheen, Andre J.
   Rissanen, Aila M.
   Roessner, Stephan
   Hanotin, Corinne
   Ziegler, Olivier
CA RIO Europe Study Grp
TI Long-term effect of CB1 blockade with rimonabant on
   cardiometabolic risk factors:: two year results from the RIO-Europe
   Study
SO EUROPEAN HEART JOURNAL
LA English
DT Article
DE CB1 receptor; cardiovascular risk factors; endocannabinoid system;
   overweight; obesity; rimonabant
ID CANNABINOID-1 RECEPTOR BLOCKER; WEIGHT-LOSS; CARDIOVASCULAR RISK;
   ENDOCANNABINOID SYSTEM; ANTAGONIST SR141716; OVERWEIGHT PATIENTS;
   PHYSICAL-ACTIVITY; OBESITY; DISEASE; PATHOPHYSIOLOGY
AB Aims Rimonabant, the first selective cannabinoid type 1 receptor blocker, has been shown to produce weight loss and improvements in several cardiometabolic risk factors over 1 year. We report the 2 year efficacy and tolerability data of rimonabant.
   Methods and results Patients with a body mass index >= 30 or > 27 kg/m(2) with treated/untreated hypertension, dyslipidaemia, or both, were randomized to double-blind treatment with placebo, rimonabant 5 or 20 mg once daily plus a calorie-restricted diet for 2 years. Weight loss from baseline to 2 years in the intention-to-treat population was significantly greater with rimonabant 20 mg (mean +/- SD: -5.5 +/- 7.7 kg; P < 0.001) and 5 mg (-2.9 +/- 6.5 kg; P = 0.002) than placebo (-1.2 +/- 6.8 kg). Rimonabant 20 mg produced significantly greater improvements than placebo in waist circumference, high-density lipoprotein cholesterol, triglycerides, fasting glucose and insulin levels, insulin resistance, and metabolic syndrome prevalence. Rimonabant 20 mg produced clinically meaningful improvements in all Impact of Weight on Quality of Life-Lite questionnaire domain scores at 2 years. Rimonabant was generally well tolerated and rates of adverse events, including depressed mood disorders and disturbances were similar to placebo during year 2. Proportions of patients with clinically significant depression (Hospital Anxiety and Depression Scale score > 11) were similar in all treatment groups.
   Conclusions Rimonabant 20 mg over 2 years promoted clinically relevant and durable weight loss and improvements in cardiometabolic risk factors.
C1 [Van Gaal, Luc F.] Univ Antwerp Hosp, Dept Diabet Metab & Clin Nutr, B-2650 Edegem, Belgium.
   [Scheen, Andre J.] Univ Liege, Acad Hosp, Div Diabet Nutr & Metab Disorders, Liege, Belgium.
   [Rissanen, Aila M.] Univ Helsinki, Cent Hosp, Obes Res Unit, Helsinki, Finland.
   [Roessner, Stephan] Karolinska Univ Hosp, Obes Unit, Huddinge, Sweden.
   [Hanotin, Corinne] Sanofi Aventis, Paris, France.
   [Ziegler, Olivier] CHU Nancy, Serv Diabetol, Maladies Nutr Hosp, Toul, France.
C3 University of Antwerp; University of Liege; University of Helsinki;
   Helsinki University Central Hospital; Karolinska Institutet; Karolinska
   University Hospital; Sanofi-Aventis; CHU de Nancy
RP Van Gaal, LF (corresponding author), Univ Antwerp Hosp, Dept Diabet Metab & Clin Nutr, Wilrijkstr 10, B-2650 Edegem, Belgium.
EM luc.van.gaal@uza.be
OI Krempf, Michel/0000-0002-4353-9511
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NR 34
TC 121
Z9 128
U1 0
U2 18
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0195-668X
EI 1522-9645
J9 EUR HEART J
JI Eur. Heart J.
PD JUL
PY 2008
VL 29
IS 14
BP 1761
EP 1771
DI 10.1093/eurheartj/ehn076
PG 11
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 328HB
UT WOS:000257787900014
PM 18417461
OA Green Submitted, Bronze
DA 2025-06-11
ER

PT J
AU Santos, IS
   Goulart, AC
   Brunoni, AR
   Kemp, AH
   Lotufo, PA
   Bensenor, IM
AF Santos, Itamar S.
   Goulart, Alessandra C.
   Brunoni, Andre R.
   Kemp, Andrew H.
   Lotufo, Paulo A.
   Bensenor, Isabela M.
TI Anxiety and depressive symptoms are associated with higher carotid
   intima-media thickness. Cross-sectional analysis from ELSA-Brasil
   baseline data
SO ATHEROSCLEROSIS
LA English
DT Article
DE Intima-media thickness; Atherosclerosis; Depression; Anxiety; Common
   mental disorder; Generalized anxiety disorder
ID CORONARY-HEART-DISEASE; CARDIOVASCULAR-DISEASE; ARTERY INTIMA;
   RISK-FACTOR; SUBCLINICAL ATHEROSCLEROSIS; MYOCARDIAL-INFARCTION;
   METABOLIC SYNDROME; YOUNG-ADULTS; HEALTH; OLDER
AB Background: Studies focusing on the association between anxiety/depressive symptoms and accelerated subclinical atherosclerosis have yielded mixed results. Our aim is to examine associations between anxiety/depressive symptoms, common mental disorder (CMD), major depression disorder (MDD) or generalized anxiety disorder (GAD) and carotid intima-media thickness (CIMT) in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) cohort baseline.
   Methods: The ELSA-Brasil baseline assessment included CIMT measurements and the Clinical Interview Schedule - Revised (CIS-R), a validated questionnaire for anxiety/depressive symptoms/diagnoses. We analyzed participants without previous coronary heart disease or stroke, and with high-quality CIMT images. We built regression models to determine whether the CIS-R score, CMD, MDD or GAD were associated with maximal CIMT levels.
   Results: The study sample comprised 9744 participants. We found that individuals with higher CIS-R scores (Odds ratio for one standard deviation increase [OR]: 1.12; 95% confidence interval [95% CI]: 1.06-1.19), CMD (OR: 1.22; 95% CI: 1.07-1.38) and GAD (OR: 1.19; 95% CI: 1.01-1.41) had significantly higher odds of being classified in the highest age, sex and race-specific CIMT quartile. In the linear models, after adjustment for traditional cardiovascular risk factors, higher CIS-R scores (beta:0.005; P = 0.010) and GAD (beta: 0.010; P = 0.049) were independently associated with CIMT values.
   Conclusion: Individuals with more symptoms of anxiety and/or depression, or diagnoses of CMD or GAD, had higher CIMT values, compared to peers of same age, sex and race. CIS-R scores and GAD were independently associated with higher CIMT values. These results suggest an association between anxiety/depressive symptoms (and, most notably, GAD) and accelerated subclinical atherosclerosis. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
C1 [Santos, Itamar S.; Goulart, Alessandra C.; Brunoni, Andre R.; Kemp, Andrew H.; Lotufo, Paulo A.; Bensenor, Isabela M.] Univ Sao Paulo, Univ Hosp, Ctr Pesquisa Clin & Epidemiol, BR-05508000 Sao Paulo, SP, Brazil.
   [Santos, Itamar S.; Lotufo, Paulo A.; Bensenor, Isabela M.] Univ Sao Paulo, Fac Med, BR-05508000 Sao Paulo, SP, Brazil.
   [Kemp, Andrew H.] Univ Sydney, Sch Psychol, Sydney, NSW 2006, Australia.
   [Kemp, Andrew H.] Univ Sydney, Discipline Psychiat, Sydney, NSW 2006, Australia.
C3 Universidade de Sao Paulo; Universidade de Sao Paulo; University of
   Sydney; University of Sydney
RP Santos, IS (corresponding author), Univ Sao Paulo, Univ Hosp, Ctr Pesquisa Clin & Epidemiol, Ave Prof Lineu Prestes 2565,3 Andar,Cidade Univ, BR-05508000 Sao Paulo, SP, Brazil.
EM itamarss@usp.br
RI Bensenor, Isabela/L-3306-2017; Lotufo, Paulo/A-9843-2008; Santos,
   Itamar/K-7055-2012; C Goulart, Alessandra/J-2845-2014; Russowsky
   Brunoni, Andre/H-8394-2012; Kemp, Andrew/C-7984-2012
OI Lotufo, Paulo/0000-0002-4856-8450; Santos, Itamar/0000-0003-3212-8466; C
   Goulart, Alessandra/0000-0003-1076-5210; Russowsky Brunoni,
   Andre/0000-0002-6310-3571; Kemp, Andrew/0000-0003-1146-3791
FU Brazilian Ministry of Health (Science and Technology Department);
   Brazilian Ministry of Science and Technology (Financiadora de Estudos e
   Projetos) [01 06 0010.00 RS, 01 06 0212.00 BA, 01 06 0300.00 ES, 01 06
   0278.00 MG, 01 06 0115.00 SP, 01 06 0071.00 RJ]; Brazilian Ministry of
   Science and Technology (CNPq National Research Council) [01 06 0010.00
   RS, 01 06 0212.00 BA, 01 06 0300.00 ES, 01 06 0278.00 MG, 01 06 0115.00
   SP, 01 06 0071.00 RJ]
FX The ELSA-Brasil baseline study was supported by the Brazilian Ministry
   of Health (Science and Technology Department) and the Brazilian Ministry
   of Science and Technology (Financiadora de Estudos e Projetos and CNPq
   National Research Council) (grants 01 06 0010.00 RS, 01 06 0212.00 BA,
   01 06 0300.00 ES, 01 06 0278.00 MG, 01 06 0115.00 SP, 01 06 0071.00 RJ).
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NR 65
TC 38
Z9 38
U1 0
U2 14
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0021-9150
EI 1879-1484
J9 ATHEROSCLEROSIS
JI Atherosclerosis
PD JUN
PY 2015
VL 240
IS 2
BP 529
EP 534
DI 10.1016/j.atherosclerosis.2015.04.800
PG 6
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA CI1ZQ
UT WOS:000354544300038
PM 25955192
DA 2025-06-11
ER

PT J
AU Schuch, JJJ
   Roest, AM
   Nolen, WA
   Penninx, BWJH
   de Jonge, P
AF Schuch, Jerome J. J.
   Roest, Annelieke M.
   Nolen, Willem A.
   Penninx, Brenda W. J. H.
   de Jonge, Peter
TI Gender differences in major depressive disorder: Results from the
   Netherlands study of depression and anxiety
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Depression; Women; Gender; Comorbidity
ID NATIONAL COMORBIDITY SURVEY; SUBSTANCE USE DISORDERS; MENTAL-HEALTH
   SURVEY; SEX-DIFFERENCES; MOOD DISORDERS; EPIDEMIOLOGIC FINDINGS;
   ATYPICAL DEPRESSION; SYMPTOMATOLOGY IDS; METABOLIC SYNDROME;
   RISK-FACTORS
AB Background: Although an overall gender difference in prevalence of major depressive disorder (MDD) has been well established, several questions concerning gender differences in the clinical manifestation of depression remain. This study aims to identify gender differences in psychopathology, treatment, and public health consequences in patients with MDD.
   Methods: Baseline data from the Netherlands Study of Depression and Anxiety (NESDA) were used, including 1115 participants (364 men, 751 women, mean age 41 years) with a DSM-IV diagnosis of current MDD. Characteristics studied included symptom profiles, comorbidity, treatment, and public health consequences.
   Results: Women reported a younger age of onset of single (27.8 years vs. 31.6 years; p=0.001) and recurrent MDD (24.8 years vs. 27.6 years; p=0.014), a higher comorbidity of panic disorder with agoraphobia (24.9% vs. 17.3%; p=0.006) and life-time overall anxiety disorder (77.6% vs. 714%; p=0.029) than men. More men than women suffered from comorbid alcohol dependence or abuse (48.1% vs. 24.5%; p < 0.001). An increased prevalence of atypical depression in women (24.6% vs. 17.3%; p=0.009) was found. Women were treated more frequently by an alternative caretaker (20.6% vs. 14.8%; p=0.025), men more often in mental health care organizations (61.0% vs. 53.7%; p=0.025). No gender differences in frequency of medication use or counseling were found.
   Limitations: Cross sectional design.
   Conclusions: Main gender differences in the clinical presentation of MDD concerned a younger age of onset, higher anxiety and lower alcohol use comorbidity and higher prevalence of atypical depression in women. These differences were accompanied by differences in health care use. (C) 2013 Elsevier B.V. All rights reserved
C1 [Schuch, Jerome J. J.; Roest, Annelieke M.; Nolen, Willem A.; Penninx, Brenda W. J. H.; de Jonge, Peter] Univ Groningen, Univ Med Ctr Groningen, Dept Psychiat, NL-9713 GZ Groningen, Netherlands.
   [Schuch, Jerome J. J.; Roest, Annelieke M.; Nolen, Willem A.; Penninx, Brenda W. J. H.; de Jonge, Peter] Univ Groningen, Univ Med Ctr Groningen, Interdisciplinary Ctr Psychopathol & Emot Regulat, NL-9713 GZ Groningen, Netherlands.
   [Penninx, Brenda W. J. H.] Vrije Univ Amsterdam, Med Ctr, Dept Psychiat, EMGO Inst Neurosci, Amsterdam, Netherlands.
   [Penninx, Brenda W. J. H.] Leiden Univ, Med Ctr, Dept Psychiat, Leiden, Netherlands.
C3 University of Groningen; University of Groningen; Vrije Universiteit
   Amsterdam; Leiden University - Excl LUMC; Leiden University; Leiden
   University Medical Center (LUMC)
RP Schuch, JJJ (corresponding author), Univ Groningen, Univ Med Ctr Groningen, Dept Psychiat, Hanzeplein 1, NL-9713 GZ Groningen, Netherlands.
EM h.j.j.schuch@umcg.nl
RI Nolen, Willem/E-9006-2014; Penninx, Brenda/S-7627-2017; de Jonge,
   Peter/L-6395-2013
OI Roest, Annelieke/0000-0002-7997-8559; de Jonge,
   Peter/0000-0002-0866-6929
FU Netherlands Organization for Health Research and Development (Zon-Mw)
   [10-000-1002]; VU University Medical Center; GGZ inGeest; Arkin; Leiden
   University Medical Center; GGZ Rivierduinen; University Medical Center
   Groningen; Lentis; GGZ Friesland; GGZ Drenthe; Scientific Institute for
   Quality of Healthcare (IQ healthcare)); Netherlands Institute for Health
   Services Research (NIVEL); Netherlands Institute of Mental Health; Dutch
   Medical Research Council [016.086.397]
FX The infrastructure for the NESDA study (www.nesda.nl) is funded through
   the Geestkracht program of the Netherlands Organization for Health
   Research and Development (Zon-Mw, Grant number 10-000-1002) and is
   supported by participating universities and mental health care
   organizations (VU University Medical Center, GGZ inGeest, Arkin, Leiden
   University Medical Center, GGZ Rivierduinen, University Medical Center
   Groningen, Lentis, GGZ Friesland, GGZ Drenthe, Scientific Institute for
   Quality of Healthcare (IQ healthcare)), Netherlands Institute for Health
   Services Research (NIVEL) and Netherlands Institute of Mental Health and
   Addiction (Trimbos Institute).Dr. R de Jonge is supported by a VIDI
   grant from the Dutch Medical Research Council (Grant 016.086.397).
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NR 54
TC 200
Z9 225
U1 2
U2 83
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD MAR
PY 2014
VL 156
BP 156
EP 163
DI 10.1016/j.jad.2013.12.011
PG 8
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA 296WI
UT WOS:000330215700020
PM 24388685
DA 2025-06-11
ER

PT J
AU Cezaretto, A
   Pakseresht, M
   Sharma, S
   Kolandooz, F
   Siqueira-Catania, A
   de Barros, CR
   Ferreira, SRG
AF Cezaretto, Adriana
   Pakseresht, Mohammadreza
   Sharma, Sangita
   Kolandooz, Fariba
   Siqueira-Catania, Antonela
   de Barros, Camila Risso
   Gouvea Ferreira, Sandra Roberta
TI Influence of depression on cardiometabolic responses to a lifestyle
   intervention in at-risk individuals
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Depression; Lifestyle intervention; Obesity; Cardiometabolic diseases
ID TYPE-2 DIABETES-MELLITUS; CORONARY-HEART-DISEASE; METABOLIC SYNDROME;
   YOUNG-ADULTS; HYPERTENSION INCIDENCE; MENTAL-DISORDERS; PUBLIC-HEALTH;
   PRIMARY-CARE; PREVALENCE; METAANALYSIS
AB Background: Cardiometabolic diseases and depression are public health problems that are often related. The benefits of behavioral interventions on lifestyle are well documented. However, the influence of depression in these interventions is unclear.
   Objective: To evaluate whether depression affects the impact of a lifestyle intervention on cardiometabolic response in an at-risk sample.
   Methods: 129 individuals identified by the public health system to be at risk for cardiometabolic disease were allocated to 18-month interventions on diet and physical activity. Socio-demographic and clinical data were obtained. Depressive symptoms were assessed by the Beck Depression Inventory. Changes by at least 10% in each of 6 cardiometabolic risk factors were used to define responses to intervention. Logistic regression models were employed for each gender.
   Results: Approximately 42% of individuals had depressive symptoms. They had higher adiposity, cholesterol, and blood pressure levels and lower quality of life and physical activity levels than non-depressed individuals. In adjusted models, only women with depression at baseline had lower chance of improving plasma glucose (OR: 0.32) and lower chance of improving mean blood pressure (OR: 0.29) after the follow-up, compared with non-depressed women.
   Limitations: The small sample size may have diminished the power of the results and the instrument used to measure depression does not provide clinical diagnosis according to DSM criteria.
   Conclusion: Depression at baseline of lifestyle interventions predicted a lower chance of improving long-term cardiometabolic risk, particularly in women, suggesting that screening and management of depression as part of lifestyle interventions can potentially improve cardiometabolic risk profile. (C) 2014 Elsevier B.V. All rights reserved,
C1 [Cezaretto, Adriana; Siqueira-Catania, Antonela; de Barros, Camila Risso; Gouvea Ferreira, Sandra Roberta] Univ Sao Paulo, Dept Nutr, Sch Publ Hlth, BR-01246904 Sao Paulo, Brazil.
   [Pakseresht, Mohammadreza; Sharma, Sangita; Kolandooz, Fariba] Univ Alberta, Dept Med, Edmonton, AB, Canada.
C3 Universidade de Sao Paulo; University of Alberta
RP Ferreira, SRG (corresponding author), Univ Sao Paulo, Fac Saude Publ, Dept Epidemiol, Av Dr Arnaldo 715, BR-01246904 Sao Paulo, Brazil.
EM sandrafv@usp.br
RI Ferreira, Sandra/B-9840-2012; Cezaretto, Adriana/A-4180-2015
OI Ferreira, Sandra/0000-0002-7015-7391; Sharma,
   Sangita/0000-0002-4995-0010
FU Sao Paulo Foundation for Research Support - FAPESP, Sao Paulo, Brazil
   [11/06376-7]; Research Internships Abroad linked to Doctorate
   [13/03430-6];  [07/55120-0]; Fundacao de Amparo a Pesquisa do Estado de
   Sao Paulo (FAPESP) [11/06376-7] Funding Source: FAPESP
FX This study was supported by Sao Paulo Foundation for Research Support -
   FAPESP, Sao Paulo, Brazil, with a Doctorate Scholarship (Process number
   11/06376-7) and a Research Internships Abroad linked to Doctorate
   (Process number: 13/03430-6) for Adriana Cezaretto and; a grant to
   Research for Sandra RG Ferreira (Process number 07/55120-0).
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NR 53
TC 6
Z9 7
U1 0
U2 14
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD MAR 15
PY 2015
VL 174
BP 516
EP 521
DI 10.1016/j.jad.2014.12.037
PG 6
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA CC0CY
UT WOS:000350003800070
PM 25554997
DA 2025-06-11
ER

PT J
AU Perry, BI
   Oltean, BP
   Jones, PB
   Khandaker, GM
AF Perry, Benjamin, I
   Oltean, Bianca P.
   Jones, Peter B.
   Khandaker, Golam M.
TI Cardiometabolic risk in young adults with depression and evidence of
   inflammation: A birth cohort study
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE Depression; Inflammation; CRP; Cardiometabolic risk factors;
   Cardiovascular; ALSPAC
ID C-REACTIVE PROTEIN; TUMOR-NECROSIS-FACTOR; INSULIN-RESISTANCE;
   PSYCHIATRIC-DISORDER; BIPOLAR DISORDER; OBESITY; ASSOCIATION; DISEASE;
   SCHIZOPHRENIA; FEATURES
AB Background: Young adults with depression and evidence of inflammation may represent a high-risk group for cardiometabolic disorders, but studies of cardiometabolic risk in this population are scarce. We aimed to examine: (1) the prevalence of low-grade inflammation in young-adults with depression; (2) cross-sectional and longitudinal associations between cardiometabolic risk factors and depression with or without evidence of inflammation.
   Method: The ALSPAC birth cohort participants were assessed for depression and serum high-sensitivity C-Reactive Protein (CRP) levels at age 18, alongside cardiometabolic measures (fasting insulin, fasting plasma glucose, low-density lipoprotein, high-density lipoprotein, triglycerides, smoking, alcohol intake) at age 18 years, and body mass index at ages 9, 13 and 18 years. Low-grade inflammation was defined as CRP> 3 mg/L. Multinomial regression was used to examine associations of cardiometabolic markers with depression cases with and without evidence of inflammation. Sensitivity analyses were conducted to examine for interactions between depression, inflammation and cardiometabolic traits.
   Results: Out of 2932 participants, 215 met ICD-10 criteria for depressive episode at age 18 years; 23 (10.7 %) had CRP> 3 mg/L and 57 (26.5 %) had CRP 1-3 mg/L. Depressive episode with raised CRP (> 3 mg/L) was associated with higher triglycerides (adjusted OR =2.09; 95 % C.I., 1.35-3.24), higher BMI (adjusted OR=1.13; 95 % C.I., 1.05-1.22) and insulin insensitivity (adjusted OR=1.12; 95 % C.I., 1.01-1.26), and longitudinally with higher BMI at ages 9 (adjusted OR=1.27; 95 % C.I., 1.10-1.48) and 13 (adjusted OR=1.23; 95 % C.I., 1.09-1.38). There was evidence for interaction between BMI and CRP for the risk of depression at age 18 (adjusted OR for the interaction term=1.56; 95 % C.I. 0.98-2.02) and between CRP and depressive symptoms for the risk of increased BMI at age 18 (adjusted beta for the interaction term=0.05; 95 % C.I. 0.00-0.12).
   Conclusions: A notable proportion of young adults with depression have evidence of inflammation. These individuals are at increased risk of cardiometabolic disorders. Management of cardiometabolic risk in depressed individuals with evidence of inflammation should form part of routine clinical practice.
C1 [Perry, Benjamin, I; Oltean, Bianca P.; Jones, Peter B.; Khandaker, Golam M.] Univ Cambridge, Dept Psychiat, Sch Clin Med, Cambridge, England.
   [Perry, Benjamin, I; Jones, Peter B.; Khandaker, Golam M.] Cambridgeshire & Peterborough NHS Fdn Trust, Cambridge, England.
C3 University of Cambridge
RP Perry, BI (corresponding author), Univ Cambridge, Dept Psychiat, Inflammat & Psychiat Res Grp, Herchel Smith Bldg,Robinson Way, Cambridge CB2 0SZ, England.
EM bip20@medschl.cam.ac.uk
RI Khandaker, Gulam/G-6171-2019; Jones, Peter/AGE-5945-2022
OI Khandaker, Golam/0000-0002-4935-9220; Oltean, Bianca
   Petronela/0009-0000-6560-193X; Perry, Benjamin I./0000-0002-1533-026X;
   Jones, Peter Brian/0000-0002-0387-880X
FU National Institute for Health Research (NIHR) [DRF-2018-11-ST2-018]; MQ:
   Transforming Mental Health (Data Science Award) [MQDS17/40]; Wellcome
   Trust (Intermediate Clinical Fellowship) [201486/Z/16/Z]; Medical
   Research Council (MICA: Mental Health Data Pathfinder) [MC_PC_17213];
   BMA Foundation J Moulton Grant; UK Medical Research Council; Wellcome
   [102215/2/13/2]; University of Bristol; Wellcome Trust
   [08426812/Z/07/Z]; MRC [MC_PC_17213, MC_PC_19009] Funding Source: UKRI;
   National Institutes of Health Research (NIHR) [DRF-2018-11-ST2-018]
   Funding Source: National Institutes of Health Research (NIHR)
FX BIP is funded by National Institute for Health Research (NIHR),
   (Doctoral Research Fellowship, DRF-2018-11-ST2-018) for this research
   project. This paper presents independent research funded by the National
   Institute for Health Research (NIHR). The views expressed are those of
   the author(s) and not necessarily those of the NHS, the NIHR or the
   Department of Health and Social Care. GMK acknowledges funding support
   from the MQ: Transforming Mental Health (Data Science Award; grant code:
   MQDS17/40), the Wellcome Trust (Intermediate Clinical Fellowship; grant
   code: 201486/Z/16/Z), the Medical Research Council (MICA: Mental Health
   Data Pathfinder; grant code: MC_PC_17213), and the BMA Foundation J
   Moulton Grant (2019). The UK Medical Research Council and Wellcome
   (Grant ref: 102215/2/13/2) and the University of Bristol provide core
   support for ALSPAC. This publication is the work of the authors and the
   authors will serve as guarantors for the contents of this paper. A
   comprehensive list of grants funding is available on the ALSPAC website:
   http://www.bristol.ac.uk/alspac/external/documents/grantacknowledgements
   .pdf/.This research was specifically funded by The Wellcome Trust (Grant
   no. 08426812/Z/07/Z) (Awardee: Dr Golam M Khandaker).
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NR 51
TC 10
Z9 13
U1 0
U2 4
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD JUN
PY 2020
VL 116
AR 104682
DI 10.1016/j.psyneuen.2020.104682
PG 8
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA LY7SQ
UT WOS:000540728400003
PM 32339985
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Mustac, F
   Matovinovic, M
   Galijasevic, T
   Skaric, M
   Podolski, E
   Perko, T
   Marcinko, D
AF Mustac, Filip
   Matovinovic, Martina
   Galijasevic, Tin
   Skaric, Maja
   Podolski, Eva
   Perko, Toma
   Marcinko, Darko
TI A Review of the Literature Relationship between Psychological Eating
   Patterns and the Risk of Type 2 Diabetes Mellitus and Metabolic Syndrome
SO DIABETOLOGY
LA English
DT Review
DE diabetes mellitus; metabolic syndrome; obesity; eating patterns; binge
   eating; emotional eating
ID REDUCED MEAL FREQUENCY; CHRONIC STRESS; CALORIC RESTRICTION;
   NORMAL-WEIGHT; FOOD CHOICE; OBESITY; HEALTH; MANAGEMENT; IMPACT;
   VULNERABILITY
AB Mental health today includes much more than the treatment of psychiatric disorders. More and more interventions aim to bring mental health support closer to people and psychotherapeutic interventions to people with somatic conditions. Since the treatment of people with metabolic syndrome and diabetes mellitus type 2 also requires a change in lifestyle, mental health has a prominent role. This overview paper wants to offer a solution after recognizing the given patterns where psychotherapy certainly has a significant and irreplaceable role. Precisely because of this phenomenon, psychological eating patterns associated with diabetes mellitus and hence metabolic syndrome should be studied, and attempts should be made to uncover patterns in occurrence. The aim of this study is to review the literature and consider the connection among diabetes mellitus, metabolic syndrome, and psychological eating patterns such as emotional and compulsive eating, as well as through the lens of food addiction. Furthermore, we have attempted to uncover the role of psychiatry and psychotherapy in the treatment of diabetes mellitus and metabolic syndrome and delve into the complexity of recognizing these patterns and emphasize the importance of a multidisciplinary approach in the treatment of diabetes mellitus and metabolic syndrome.
C1 [Mustac, Filip; Marcinko, Darko] Univ Hosp Ctr Zagreb, Dept Psychiat & Psychol Med, Kispaticeva 12, Zagreb 10000, Croatia.
   [Matovinovic, Martina] Univ Hosp Ctr Zagreb, Croatian Referral Ctr Obes Treatment, Dept Internal Med, Div Endocrinol, Kispaticeva 12, Zagreb 10000, Croatia.
   [Galijasevic, Tin] Gen Hosp Varazdin, Varazhdin 42000, Croatia.
   [Skaric, Maja] Neuropsychiat Hosp Dr Ivan Barbot, Popovaca 44317, Croatia.
   [Podolski, Eva; Perko, Toma; Marcinko, Darko] Univ Zagreb, Sch Med, Zagreb 10000, Croatia.
C3 University of Zagreb; UNIVERSITY ZAGREB HOSPITAL; University of Zagreb;
   UNIVERSITY ZAGREB HOSPITAL; University of Zagreb
RP Mustac, F (corresponding author), Univ Hosp Ctr Zagreb, Dept Psychiat & Psychol Med, Kispaticeva 12, Zagreb 10000, Croatia.; Matovinovic, M (corresponding author), Univ Hosp Ctr Zagreb, Croatian Referral Ctr Obes Treatment, Dept Internal Med, Div Endocrinol, Kispaticeva 12, Zagreb 10000, Croatia.
EM filip.mustac@gmail.com; martina_10000@yahoo.com; kopaka@oems.hr;
   skaric.maja@gmail.com; evapodolski3@gmail.com; toma.perko@gmail.com;
   niarveda@gmail.com
RI Mustač, Filip/AHI-7952-2022
OI Mustac, Filip/0000-0003-2851-6183
FX This research received no external funding.
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NR 85
TC 0
Z9 0
U1 3
U2 4
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2673-4540
J9 DIABETOLOGY
JI Diabetol.
PD SEP
PY 2024
VL 5
IS 4
BP 365
EP 374
DI 10.3390/diabetology5040028
PG 10
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA H4N2X
UT WOS:001323218800001
OA gold
DA 2025-06-11
ER

PT J
AU Sharma, H
   Kumar, P
   Deshmukh, RR
   Bishayee, A
   Kumar, S
AF Sharma, Hitender
   Kumar, Pushpander
   Deshmukh, Rahul R.
   Bishayee, Anupam
   Kumar, Sunil
TI Pentacyclic triterpenes: New tools to fight metabolic syndrome
SO PHYTOMEDICINE
LA English
DT Review
DE Pentacyclic triterpenes; Metabolic syndrome; Transcription factors;
   Protein kinase; Insulin resistance
ID TYROSINE-PHOSPHATASE 1B; AMELIORATES INSULIN-RESISTANCE; URSOLIC ACID;
   OXIDATIVE STRESS; ENDOTHELIAL DYSFUNCTION; HEPATIC STEATOSIS; OLEANOLIC
   ACID; CARDIOVASCULAR-DISEASE; HIGH-CARBOHYDRATE; COROSOLIC ACID
AB Background: Metabolic syndrome is a combination of dysregulated cardiometabolic risk factors characterized by dyslipidemia, impaired glucose tolerance, insulin resistance, inflammation, obesity as well as hypertension. These factors are tied to the increased risk for type-II diabetes and cardiovascular diseases including myocardial infarction in patients with metabolic syndrome.
   Purpose: To review the proposed molecular mechanisms of pentacyclic triterpenes for their potential use in the metabolic syndrome.
   Methods: PubMed, Science Direct, and Google Scholar database were searched from commencement to April 2018. Following keywords were searched in the databases with varying combinations: "metabolic syndrome", "pentacyclic triterpenes", "transcription factors", "protein kinase", "lipogenesis", "adipogenesis", "lipolysis", "fatty acids", "gluconeogenesis", "cardiovascular", "mitochondria", "oxidative stress", "pancreas", "hepatic cells", "skeletal muscle", "3T3-L1", "C2C12", "obesity", "inflammation", "insulin resistance", "glucose uptake", "clinical studies" and "bioavailability".
   Results: Pentacyclic triterpenes, such as asiatic acid, ursolic acid, oleanolic acid, 18 beta-glycyrrhetinic acid, a, beta-amyrin, celastrol, carbenoxolone, corosolic acid, maslinic acid, bardoxolone methyl and lupeol downregulate several metabolic syndrome components by regulating transcription factors, protein kinases and enzyme involved in the adipogenesis, lipolysis, fatty acid oxidation, insulin resistance, mitochondria biogenesis, gluconeogenesis, oxidative stress and inflammation.
   Conclusion: In vitro and in vivo studies suggests that pentacyclic triterpenes effectively downregulate various factors related to metabolic syndrome. These phytochemicals may serve as promising candidates for clinical trials for the management of metabolic syndrome.
C1 [Sharma, Hitender; Kumar, Pushpander; Kumar, Sunil] Kurukshetra Univ, Inst Pharmaceut Sci, Kurukshetra 136119, Haryana, India.
   [Deshmukh, Rahul R.] Lake Erie Coll Osteopath Med, Sch Pharm, Bradenton, FL 34211 USA.
   [Bishayee, Anupam] Lake Erie Coll Osteopath Med, Coll Osteopath Med, Bradenton, FL 34211 USA.
C3 Kurukshetra University
RP Kumar, S (corresponding author), Kurukshetra Univ, Inst Pharmaceut Sci, Kurukshetra 136119, Haryana, India.
EM sunilmadhuban@kuk.ac.in
RI Sharma, Hitender/KXQ-9758-2024; Deshmukh, Rahul/AAU-1316-2020; Bishayee,
   Anupam/G-4290-2012; Kumar, Sunil/ABF-5435-2021; Kumar, Sunil/F-5301-2019
OI Bishayee, Anupam/0000-0001-9159-960X; Kumar, Sunil/0000-0002-5905-3372;
   , Hitender/0000-0003-0540-7574
FU DST-SERB, New Delhi [SB/FTP/ETA-0358/2013]
FX Dr. Sunil Kumar is thankful to DST-SERB, New Delhi for an award of Fast
   Track Young Scientist [F.No.SB/FTP/ETA-0358/2013].
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NR 152
TC 86
Z9 88
U1 3
U2 74
PU ELSEVIER GMBH, URBAN & FISCHER VERLAG
PI JENA
PA OFFICE JENA, P O BOX 100537, 07705 JENA, GERMANY
SN 0944-7113
J9 PHYTOMEDICINE
JI Phytomedicine
PD NOV 15
PY 2018
VL 50
BP 166
EP 177
DI 10.1016/j.phymed.2018.09.011
PG 12
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA HB9TN
UT WOS:000451435900018
PM 30466975
DA 2025-06-11
ER

PT J
AU Cheng, HL
   Medlow, S
   Steinbeck, K
AF Cheng, Hoi Lun
   Medlow, Sharon
   Steinbeck, Katharine
TI The Health Consequences of Obesity in Young Adulthood
SO CURRENT OBESITY REPORTS
LA English
DT Article
DE Young adult; Obesity; Metabolic syndrome X; Mental health; Polycystic
   ovary syndrome
ID POLYCYSTIC-OVARY-SYNDROME; BODY-MASS INDEX; WEIGHT-LOSS INTERVENTIONS;
   YOUTH MENTAL-HEALTH; URINARY-INCONTINENCE; CARDIOVASCULAR-DISEASE;
   METABOLIC SYNDROME; OVERWEIGHT WOMEN; RISK-FACTORS; CHILDREN
AB Young adults are gaining weight faster than any age group. This weight gain and the appearance of obesity-related comorbidities often commence in adolescence. Psychosocial distress and mental health issues are common and debilitating, and treatment approaches are likely to be similar to those for adolescents. At the same time, young adults may have physical morbidities which will continue and worsen throughout adulthood, such as hypertension, diabetes and polycystic ovarian syndrome. Health consequences of obesity are challenging to manage in young adults as their symptoms may be minimal, they are less likely to engage with healthcare due to other life priorities and their neurocognitive developmental stage makes therapy adherence difficult. Clinicians who manage young adults with obesity need to be aware of these age-specific challenges, as well as the sexual and reproductive health concerns that are present in this age group.
C1 [Cheng, Hoi Lun; Medlow, Sharon; Steinbeck, Katharine] Childrens Hosp Westmead, Acad Dept Adolescent Med, Cnr Hawkesbury Rd & Hainsworth St,Locked Bag 4001, Westmead, NSW 2145, Australia.
   [Cheng, Hoi Lun; Medlow, Sharon; Steinbeck, Katharine] Univ Sydney, Discipline Paediat & Child Hlth, Sydney Med Sch, Cnr Hawkesbury Rd & Hainsworth St,Locked Bag 4001, Westmead, NSW 2145, Australia.
C3 NSW Health; The Children's Hospital at Westmead; University of Sydney;
   Sydney Childrens Hospitals Network; University of Sydney
RP Steinbeck, K (corresponding author), Childrens Hosp Westmead, Acad Dept Adolescent Med, Cnr Hawkesbury Rd & Hainsworth St,Locked Bag 4001, Westmead, NSW 2145, Australia.; Steinbeck, K (corresponding author), Univ Sydney, Discipline Paediat & Child Hlth, Sydney Med Sch, Cnr Hawkesbury Rd & Hainsworth St,Locked Bag 4001, Westmead, NSW 2145, Australia.
EM helen.cheng@health.nsw.gov.au; sharon.medlow@health.nsw.gov.au;
   kate.steinbeck@health.nsw.gov.au
RI Medlow, Sharon/GNM-9608-2022; Steinbeck, Kate/AAX-6197-2020; Cheng,
   Hoi/AAK-8937-2021
OI Cheng, Hoi Lun/0000-0002-2144-9195
FU Marie Bashir Fellowship for Clinical Research in Adolescent Health
FX HLC holds the Marie Bashir Fellowship for Clinical Research in
   Adolescent Health. KS holds the Medical Foundation Chair in Adolescent
   Medicine at the University of Sydney.
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NR 106
TC 61
Z9 76
U1 0
U2 33
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 2162-4968
J9 CURR OBES REP
JI Curr. Obes. Rep.
PD MAR
PY 2016
VL 5
IS 1
BP 30
EP 37
DI 10.1007/s13679-016-0190-2
PG 8
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA EB0SH
UT WOS:000387055300005
PM 26830309
DA 2025-06-11
ER

PT J
AU Lonardo, A
   Ndrepepa, G
AF Lonardo, Amedeo
   Ndrepepa, Gjin
TI Concise review: gamma-glutamyl transferase - evolution from an
   indiscriminate liver test to a biomarker of cardiometabolic risk
SO METABOLISM AND TARGET ORGAN DAMAGE
LA English
DT Article
DE Cardiometabolic risk; chronic kidney disease; COVID; incident type 2
   diabetes; insulin resistance; liver fibrosis; metabolic syndrome; NAFLD;
   portal hypertension
ID CHRONIC KIDNEY-DISEASE; HEART-FAILURE; HEPATIC STEATOSIS;
   OXIDATIVE-STRESS; REDOX-REGULATION; TRANSPEPTIDASE; GLUTAMYLTRANSFERASE;
   ENZYMES; ASSOCIATION; METABOLISM
AB This concise review article critically examines the recent medical literature regarding gamma glutamyl transferase (GGT) with a special emphasis on newly proposed indications for GGT use, including cardiovascular risk assessment. GGT is a ubiquitous glycosylated protein embedded in the outer surface of cell membranes, which catalyzes the transfer of glutamyl groups from various substrates and plays a key role in the antioxidant/pro-oxidant balance. In the past, the enzyme was considered a non-specific liver test. Current evidence supports the role of GGT in the assessment of portal hypertension in cystic fibrosis, porto-sinusoidal vascular disease, malignant mesothelioma, and incident type 2 diabetes and as a biomarker of cardiometabolic risk and cardiovascular disease. Several specific points including the use of GGT in hepatology as a sensitive but poorly specific test and the association of GGT with metabolic syndrome, nonalcoholic fatty liver disease and its fibrotic stages, cardiometabolic risk, chronic kidney disease, neurodegenerative disorders and dementia, idiopathic pulmonary arterial hypertension, and Corona Virus Disease 2019 (COVID-19) are addressed based on the most recent research in these fields. Putative mechanisms linking GGT with increased metabolic stress and the effects of various therapeutic interventions on GGT values are also discussed. We conclude that GGT has evolved from an indiscriminate liver test and an index of alcohol consumption to a biomarker of cardiometabolic health. The proper interpretation of GGT values (i.e., of hepatic vs. extrahepatic origin) is deeply affected by the clinical and epidemiological context. We propose that GGT may be utilized in public health campaigns, in the research arena, and in clinical practice to identify those individuals who can benefit most from the proactive preventive and therapeutic approaches, given that they are at high cardiometabolic risk.
C1 [Lonardo, Amedeo] Azienda Osped Univ Modena, Dept Internal Med, via Pozzo 71, I-41125 Modena, Italy.
   [Ndrepepa, Gjin] Tech Univ, Deutsch Herzzentrum Munchen, Dept Adult Cardiol, D-80636 Munich, Germany.
C3 Universita di Modena e Reggio Emilia; Universita di Modena e Reggio
   Emilia Hospital; Technical University of Munich; German Heart Centre
   Munich
RP Lonardo, A (corresponding author), Azienda Osped Univ Modena, Dept Internal Med, via Pozzo 71, I-41125 Modena, Italy.
EM a.lonardo@libero.it; lonardo.amedeo@aou.mo.it
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   Yogeswaran A, 2022, J HEART LUNG TRANSPL, V41, P400, DOI 10.1016/j.healun.2021.10.018
   Yoo D, 2020, SCI REP-UK, V10, DOI 10.1038/s41598-020-58306-x
   Zhao W, 2020, INT J ENDOCRINOL, V2020, DOI 10.1155/2020/5356498
   Zinterl I, 2022, LIVER INT, V42, P585, DOI 10.1111/liv.15162
NR 93
TC 13
Z9 13
U1 2
U2 2
PU OAE PUBLISHING INC
PI ALHAMBRA
PA 245 E MAIN ST, ST122, ALHAMBRA, CA 91801 USA
EI 2769-6375
J9 METAB TARGET ORGAN D
JI Metab. Target Organ Damage
PD DEC
PY 2022
VL 2
IS 4
AR 17
DI 10.20517/mtod.2022.20
PG 20
WC Endocrinology & Metabolism
WE Emerging Sources Citation Index (ESCI)
SC Endocrinology & Metabolism
GA G8F6B
UT WOS:001318933500002
OA gold
DA 2025-06-11
ER

PT S
AU Duque-Guimaraes, D
   Ong, TP
   de Almeida-Faria, J
   Guest, PC
   Ozanne, SE
AF Duque-Guimaraes, Daniella
   Ong, Thomas Prates
   de Almeida-Faria, Juliana
   Guest, Paul C.
   Ozanne, Susan E.
BE Guest, PC
TI SILAC Mass Spectrometry Profiling: A Psychiatric Disorder Perspective
SO PROTEOMIC METHODS IN NEUROPSYCHIATRIC RESEARCH
SE Advances in Experimental Medicine and Biology
LA English
DT Article; Book Chapter
ID PITUITARY-ADRENAL AXIS; DRUG-NAIVE PATIENTS; QUANTITATIVE PROTEOMICS;
   METABOLIC SYNDROME; GLUCOSE-TOLERANCE; SCHIZOPHRENIA; IDENTIFICATION;
   1ST-EPISODE; PROTEINS
C1 [Duque-Guimaraes, Daniella; Ong, Thomas Prates; de Almeida-Faria, Juliana; Ozanne, Susan E.] Univ Cambridge, Metab Res Labs, Cambridge, England.
   [Duque-Guimaraes, Daniella; Ong, Thomas Prates; de Almeida-Faria, Juliana; Ozanne, Susan E.] Addenbrookes Hosp, Wellcome Trust MRC Inst Metab Sci, MRC Metab Dis Unit, Cambridge, England.
   [Duque-Guimaraes, Daniella] Univ Sao Paulo, Inst Biomed Sci, Dept Physiol & Biophys, Sao Paulo, Brazil.
   [Ong, Thomas Prates] Univ Sao Paulo, Food Res Ctr FoRC, Sao Paulo, Brazil.
   [Ong, Thomas Prates] Univ Sao Paulo, Fac Pharmaceut Sci, Sao Paulo, Brazil.
   [de Almeida-Faria, Juliana] Univ Campinas UNICAMP, Fac Med Sci, Dept Pharmacol, Campinas, SP, Brazil.
   [Guest, Paul C.] Univ Campinas UNICAMP, Inst Biol, Dept Biochem & Tissue Biol, Lab Neuroprote, Rua Monteiro Lobato 255 F-01, BR-13083862 Campinas, SP, Brazil.
C3 University of Cambridge; University of Cambridge; Cambridge University
   Hospitals NHS Foundation Trust; Addenbrooke's Hospital; Universidade de
   Sao Paulo; Institute Biomed Science, University Sao Paulo; Universidade
   de Sao Paulo; Universidade de Sao Paulo; Universidade Estadual de
   Campinas; Universidade Estadual de Campinas
RP Ozanne, SE (corresponding author), Univ Cambridge, Metab Res Labs, Cambridge, England.; Ozanne, SE (corresponding author), Addenbrookes Hosp, Wellcome Trust MRC Inst Metab Sci, MRC Metab Dis Unit, Cambridge, England.
EM seo10@cam.ac.uk
RI Ong, Thomas/N-1272-2019; de Almeida Faria, Juliana/C-5931-2015
OI guest, paul/0000-0002-5030-7137; Ong, Thomas/0000-0002-7709-1866;
   Ozanne, Susan/0000-0001-8753-5144
FU British Heart Foundation [PG/14/20/30769] Funding Source: Medline;
   Medical Research Council [MC_UU_12012/4] Funding Source: Medline
CR Biedermann F, 2009, CURR OPIN PSYCHIATR, V22, P326, DOI 10.1097/YCO.0b013e328329cd73
   Cassoli JS, 2016, FRONT CELL NEUROSCI, V10, DOI 10.3389/fncel.2016.00052
   Chen XL, 2015, PROTEOMICS, V15, P3175, DOI 10.1002/pmic.201500108
   Fernandez C, 2008, J PROTEOME RES, V7, P400, DOI 10.1021/pr070547d
   Filiou MD, 2012, METHODS MOL BIOL, V829, P531, DOI 10.1007/978-1-61779-458-2_33
   Guest FL, 2016, BIOMARK MED, V10, P431, DOI 10.2217/bmm-2015-0055
   Guest PC, 2011, INT REV NEUROBIOL, V101, P145, DOI 10.1016/B978-0-12-387718-5.00006-7
   Hasnain M, 2010, CURR DIABETES REP, V10, P209, DOI 10.1007/s11892-010-0112-8
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NR 24
TC 1
Z9 2
U1 0
U2 1
PU SPRINGER-VERLAG BERLIN
PI BERLIN
PA HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY
SN 0065-2598
EI 2214-8019
BN 978-3-319-52479-5; 978-3-319-52478-8
J9 ADV EXP MED BIOL
JI Adv.Exp.Med.Biol.
PY 2017
VL 974
BP 289
EP 298
DI 10.1007/978-3-319-52479-5_27
D2 10.1007/978-3-319-52479-5
PG 10
WC Biology; Medicine, Research & Experimental; Neurosciences
WE Book Citation Index – Science (BKCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics; Research & Experimental
   Medicine; Neurosciences & Neurology
GA BJ3GP
UT WOS:000423115900028
PM 28353248
DA 2025-06-11
ER

PT J
AU Luppino, FS
   Dortland, AKBV
   Wardenaar, KJ
   Bouvy, PF
   Giltay, EJ
   Zitman, FG
   Penninx, BWJH
AF Luppino, Floriana S.
   Dortland, Arianne K. B. van Reedt
   Wardenaar, Klaas J.
   Bouvy, Paul F.
   Giltay, Erik J.
   Zitman, Frans G.
   Penninx, Brenda W. J. H.
TI Symptom Dimensions of Depression and Anxiety and the Metabolic Syndrome
SO PSYCHOSOMATIC MEDICINE
LA English
DT Article
DE depression; anxiety; symptom dimensions; metabolic syndrome
ID PITUITARY-ADRENAL AXIS; LATE-LIFE DEPRESSION; TRIPARTITE MODEL;
   MYOCARDIAL-INFARCTION; NATIONAL-HEALTH; RISK; ASSOCIATION; MORTALITY;
   CORTISOL; DISEASE
AB Objective: To investigate the association between depression and anxiety symptoms and the metabolic syndrome (MetSyn), using a dimensional approach. The association between depression and anxiety, on the one hand, and the MetSyn as a cluster or its individual components, on the other hand, is equivocal. The categorical nature of the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition might partly explain the inconsistent findings. Methods: In 2,433 Netherlands Study of Depression and Anxiety participants (mean age, 42.3 years; 33.1% male), three symptoms dimensions-lack of positive affect (PA, depression specific); negative affect (NA, aspecific); and somatic arousal (SA, anxiety specific)-were assessed by a shortened adaptation of the Mood and Anxiety Symptom Questionnaire. The association between symptom dimensions and MetSyn components (waist circumference, triglycerides high-density lipoprotein cholesterol, glucose, and mean blood pressure) was analyzed, using linear regression analysis. Results:: The occurrence rate of the MetSyn was 20.1% (n = 490). SA, but not PA and NA, was strongly associated with four out of five MetSyn components, especially waist circumference, triglycerides, and blood pressure (beta = 0.046, p = .01; beta = 0.077, p < .001; and beta = 0.069, p < .001, respectively), and with the total number of MetSyn components (13 = 0.098, p < .001). Conclusions: Our results demonstrate a strong association of most of the MetSyn components with the SA dimension, but not with the NA and PA scales.
C1 [Luppino, Floriana S.; Dortland, Arianne K. B. van Reedt; Wardenaar, Klaas J.; Giltay, Erik J.; Zitman, Frans G.; Penninx, Brenda W. J. H.] Leiden Univ, Med Ctr, Dept Psychiat, NL-2300 RC Leiden, Netherlands.
   [Zitman, Frans G.] GGZ Rivierduinen, Leiden, Netherlands.
   [Bouvy, Paul F.] Erasmus MC, Dept Psychiat, Rotterdam, Netherlands.
   [Penninx, Brenda W. J. H.] Vrije Univ Amsterdam Med Ctr, Dept Psychiat, EMGO Inst, Amsterdam, Netherlands.
   [Penninx, Brenda W. J. H.] Univ Groningen, Univ Med Ctr Groningen, Dept Psychiat, NL-9713 AV Groningen, Netherlands.
C3 Leiden University - Excl LUMC; Leiden University; Leiden University
   Medical Center (LUMC); Erasmus University Rotterdam; Erasmus MC; Vrije
   Universiteit Amsterdam; VU UNIVERSITY MEDICAL CENTER; University of
   Groningen
RP Luppino, FS (corresponding author), Leiden Univ, Med Ctr, Dept Psychiat, Albinusdreef 2, NL-2300 RC Leiden, Netherlands.
EM f.s.luppino@lumc.nl
RI Penninx, Brenda/S-7627-2017; Zitman, Frans/E-7705-2010; Wardenaar,
   Klaas/E-2985-2013; Giltay, Erik/AAL-9948-2021
OI Giltay, Erik J./0000-0001-8874-2292
FU Netherlands Organization for Health Research and Development (ZonMw)
   [10-000-1002]; VU University Medical Center; GGZ inGeest; Arkin; Leiden
   University Medical Center; GGZ Rivierduinen; University Medical Center
   Groningen; Lentis; GGZ Friesland; GGZ Drenthe; Scientific Institute for
   Quality of Health Care (IQ Healthcare); Netherlands Institute for Health
   Services Research (NIVEL); Netherlands Institute of Mental Health and
   Addiction (Trimbos)
FX The infrastructure for the NESDA study (available at www.nesda.nl) is
   funded, in part, by the Geestkracht program of the Netherlands
   Organization for Health Research and Development (ZonMw, Grant
   10-000-1002) and is supported, in part, by participating universities
   and mental health care organizations: VU University Medical Center, GGZ
   inGeest, Arkin, Leiden University Medical Center, GGZ Rivierduinen,
   University Medical Center Groningen, Lentis, GGZ Friesland, GGZ Drenthe,
   Scientific Institute for Quality of Health Care (IQ Healthcare),
   Netherlands Institute for Health Services Research (NIVEL), and
   Netherlands Institute of Mental Health and Addiction (Trimbos).
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NR 60
TC 49
Z9 52
U1 0
U2 13
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0033-3174
EI 1534-7796
J9 PSYCHOSOM MED
JI Psychosom. Med.
PD APR
PY 2011
VL 73
IS 3
BP 257
EP 264
DI 10.1097/PSY.0b013e31820a59c0
PG 8
WC Psychiatry; Psychology; Psychology, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry; Psychology
GA 753CC
UT WOS:000289740900006
PM 21257975
DA 2025-06-11
ER

PT J
AU Zaks, N
   Batuure, A
   Lin, E
   Rommel, AS
   Reichenberg, A
   Grice, D
   Bergink, V
   Fox, NS
   Mahjani, B
   Janecka, M
AF Zaks, Nina
   Batuure, Anita
   Lin, Emma
   Rommel, Anna-Sophie
   Reichenberg, Abraham
   Grice, Dorothy
   Bergink, Veerle
   Fox, Nathan S.
   Mahjani, Behrang
   Janecka, Magdalena
TI Association Between Mental Health and Reproductive System Disorders in
   Women: A Systematic Review and Meta-analysis
SO JAMA NETWORK OPEN
LA English
DT Review
ID POLYCYSTIC-OVARY-SYNDROME; CHRONIC PELVIC PAIN; PSYCHIATRIC-DISORDERS;
   DEPRESSION SYMPTOMS; BIPOLAR DISORDER; BODY DISSATISFACTION;
   CARDIOMETABOLIC RISK; GENDER-DIFFERENCES; SPECTRUM DISORDER; ANXIETY
AB IMPORTANCE Reproductive system and mental health disorders are commonly comorbid in women. Although the causes of this overlap remain elusive, evidence suggests potential shared environmental and genetic factors associated with risk.
   OBJECTIVE To investigate the comorbidity between psychiatric and reproductive system disorders, both as broad diagnostic categories and among specific pairs of diagnoses.
   DATA SOURCE PubMed.
   STUDY SELECTION Observational studies published between January 1980 and December 2019 assessing prevalence of psychiatric disorders in women with reproductive system disorders and prevalence of reproductive system disorders in women with psychiatric disorders were included. The study did not include psychiatric and reproductive disorders triggered by life events (eg, trauma, infection, surgery) to address potential confounding.
   DATA EXTRACTION AND SYNTHESIS A search yielded 1197 records, of which 50 met the inclusion criteria for the qualitative and 31 for the quantitative synthesis in our study. A random-effects model was used for data synthesis and Egger test and I-2 to assess study bias and heterogeneity. Data were analyzed from January to December 2022. This study followed the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guideline.
   MAIN OUTCOMES AND MEASURES Psychiatric and reproductive system disorders.
   RESULTS A total of 1197 records were identified, of which 50 met the inclusion criteria for qualitative and 31 for quantitative synthesis. Diagnosis of a reproductive system disorder was associated with a 2- to 3-fold increased odds of having a psychiatric disorder (lower bound odds ratio [OR], 2.00; 95% CI, 1.41-2.83; upper bound OR; 2.88; 95% CI, 2.21-3.76). The analysis focused on specific diagnoses described in the literature and found that polycystic ovary syndrome was associated with increased odds of depression (population-based studies OR, 1.71; 95% CI, 1.19-2.45; clinical studies OR, 2.58; 95% CI, 1.57-4.23) and anxiety (population-based studies OR, 1.69; 95% CI, 1.36-2.10; clinical studies OR, 2.85; 95% CI, 1.98-4.09). Chronic pelvic pain was also associated with both depression (OR, 3.91; 95% CI, 1.81-8.46) and anxiety (OR, 2.33; 95% CI, 1.33-4.08). Few studies investigated risk of other reproductive system disorders in women with psychiatric disorders, or reverse associations (risk of reproductive system disorder among women with a psychiatric diagnosis).
   CONCLUSIONS AND RELEVANCE In this systematic review and meta-analysis, a high rate of reported co-occurrence between psychiatric and reproductive disorders overall was observed. However, data for many disorder pairs were limited. The available literature focused overwhelmingly on affective disorders in polycystic ovary syndrome, overlooking a substantial portion of disease overlap. As such, the associations between the majority of mental health outcomes and conditions of the female reproductive system are largely unknown.
C1 [Zaks, Nina; Rommel, Anna-Sophie; Reichenberg, Abraham; Grice, Dorothy; Bergink, Veerle; Mahjani, Behrang; Janecka, Magdalena] Icahn Sch Med Mt Sinai, Dept Psychiat, 1399 Pk Ave, New York, NY 10029 USA.
   [Batuure, Anita] Rutgers State Univ, Grad Sch Appl & Profess Psychol, Piscataway, NJ USA.
   [Lin, Emma] Cornell Univ, Undergrad Studies, Ithaca, NY USA.
   [Reichenberg, Abraham; Grice, Dorothy; Mahjani, Behrang; Janecka, Magdalena] Icahn Sch Med Mt Sinai, Seaver Autism Ctr Res & Treatment, New York, NY 10029 USA.
   [Rommel, Anna-Sophie; Reichenberg, Abraham] Icahn Sch Med Mt Sinai, Dept Environm Med & Publ Hlth, New York, NY 10029 USA.
   [Grice, Dorothy; Mahjani, Behrang] Icahn Sch Med Mt Sinai, Div Tics OCD & Related Disorders, New York, NY 10029 USA.
   [Reichenberg, Abraham; Grice, Dorothy; Janecka, Magdalena] Icahn Sch Med Mt Sinai, Mindich Child Hlth & Dev Inst, New York, NY 10029 USA.
   [Bergink, Veerle] Erasmus MC, Dept Psychiat, Rotterdam, Netherlands.
   [Fox, Nathan S.] Icahn Sch Med Mt Sinai, Dept Obstet Gynecol & Reprod Sci, New York, NY 10029 USA.
   [Mahjani, Behrang] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.
   [Janecka, Magdalena] Icahn Sch Med Mt Sinai, Dept Genet & Genom Sci, New York, NY 10029 USA.
C3 Icahn School of Medicine at Mount Sinai; Rutgers University System;
   Rutgers University New Brunswick; Cornell University; Icahn School of
   Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn
   School of Medicine at Mount Sinai; Icahn School of Medicine at Mount
   Sinai; Erasmus University Rotterdam; Erasmus MC; Icahn School of
   Medicine at Mount Sinai; Karolinska Institutet; Icahn School of Medicine
   at Mount Sinai
RP Janecka, M (corresponding author), Icahn Sch Med Mt Sinai, Dept Psychiat, 1399 Pk Ave, New York, NY 10029 USA.
EM magdalena.janecka@mssm.edu
RI Grice, Dorothy/X-3372-2019; Mahjani, Behrang/AAZ-4236-2020; Reichenberg,
   Abraham/G-9877-2012; Bergink, Veerle/G-6944-2016
OI Zaks, Nina/0000-0002-6061-5213
FU Seaver Foundation; National Institute of Mental Health [MH124817]
FX We would like to acknowledge the generous support of the Seaver
   Foundation and a grant from the National Institute of Mental Health (Drs
   Janecka and Reichenberg [grant number MH124817]).
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NR 86
TC 18
Z9 19
U1 0
U2 7
PU AMER MEDICAL ASSOC
PI CHICAGO
PA 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA
SN 2574-3805
J9 JAMA NETW OPEN
JI JAMA Netw. Open
PD APR
PY 2023
VL 6
IS 4
AR e238685
DI 10.1001/jamanetworkopen.2023.8685
PG 15
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA P6CH5
UT WOS:001051530100001
PM 37071426
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Jayaweera, K
   Aschan, L
   Pannala, G
   Adikari, A
   Glozier, N
   Ismail, K
   Pariante, CM
   Rijsdijk, F
   Siribaddana, S
   Zavos, HMS
   Zunszain, PA
   Sumathipala, A
   Hotopf, M
AF Jayaweera, Kaushalya
   Aschan, Lisa
   Pannala, Gayani
   Adikari, Anushka
   Glozier, Nicholas
   Ismail, Khalida
   Pariante, Carmine M.
   Rijsdijk, Fruhling
   Siribaddana, Sisira
   Zavos, Helena M. S.
   Zunszain, Patricia A.
   Sumathipala, Athula
   Hotopf, Matthew
TI The Colombo Twin and Singleton Follow-up Study: a population based twin
   study of psychiatric disorders and metabolic syndrome in Sri Lanka
SO BMC PUBLIC HEALTH
LA English
DT Article
ID GENERALIZED ANXIETY DISORDER; CARDIOVASCULAR-DISEASE; DIABETES-MELLITUS;
   MENTAL-HEALTH; RISK-FACTORS; PREVALENCE; ADULTS; DEFINITIONS; CHILDHOOD;
   QUESTIONNAIRE
AB Background: The disease burden related to mental disorders and metabolic syndrome is growing in low-and middle-income countries (LMIC). The Colombo Twin and Singleton Study (COTASS) is a population-based sample of twins and singletons in Colombo, Sri Lanka. Here we present prevalence estimates for metabolic syndrome (metS) and mental disorders from a follow-up (COTASS-2) of the original study (COTASS-1), which was a mental health survey.
   Methods: In COTASS-2, participants completed structured interviews, anthropometric measures and provided fasting blood and urine samples. Depressive disorder, depressive symptoms, anxiety symptoms, post-traumatic stress disorder (PTSD) and hazardous alcohol use were ascertained with structured psychiatric screens (Composite International Diagnostic Interview (CIDI), Beck Depression Inventory (BDI-II), Generalised Anxiety Disorder Questionnaire (GAD-7), PTSD Checklist - Civilian Version (PCL-C), and Alcohol Use Disorders Identification Test (AUDIT)). We defined metS according to the International Diabetes Federation (IDF) criteria and the revised National Cholesterol Education Programme Adult Treatment Panel (NCEP ATP III) criteria. We estimated the prevalence of psychiatric disorders and metS and metS components, and associations with gender, education and age.
   Results: Two thousand nine hundred thirty-four twins and 1035 singletons were followed up from COTASS-1 (83.4 and 61.8% participation rate, respectively). Prevalence estimates for depressive disorder (CIDI), depressive symptoms (BDI >= 16), anxiety symptoms (GAD-7 >= 10) and PTSD (PCL-C DSM criteria) were 3.8 , 5.9, 3.6, and 4.5% respectively for twins and 3.9, 9.8, 5.1 and 5.4% for singletons. 28.1 and 30.9% of male twins and singletons respectively reported hazardous alcohol use. Approximately one third met the metS criteria (IDF: 27.4% twins, 44.6% singletons; NCEP ATP III: 30.6% twins, 48.6% singletons). The most prevalent components were central obesity (59.2% twins, 71.2% singletons) and raised fasting blood glucose or diabetes (38.2% twins, 56.7% singletons).
   Conclusion: MetS was highly prevalent in twins, and especially high in singletons, whereas the prevalence of mental disorders was low, but consistent with local estimates. The high levels of raised fasting plasma glucose and central obesity were particularly concerning, and warrant national diabetes prevention programmes.
C1 [Jayaweera, Kaushalya; Pannala, Gayani; Adikari, Anushka; Sumathipala, Athula] Inst Res & Dev, Colombo, Sri Lanka.
   [Aschan, Lisa; Ismail, Khalida; Hotopf, Matthew] Kings Coll London, Inst Psychiat Psychol & Neurosci, Psychol Med Dept, London, England.
   [Aschan, Lisa; Ismail, Khalida; Hotopf, Matthew] Kings Coll London, South London & Maudsley NHS Fdn Trust, NIHR Biomed Res Ctr Mental Hlth, London, England.
   [Glozier, Nicholas] Univ Sydney, Brain & Mind Ctr, Sydney, NSW, Australia.
   [Pariante, Carmine M.; Zunszain, Patricia A.] Kings Coll London, Inst Psychiat Psychol & Neurosci, Stress Psychiat & Immunol Lab, London, England.
   [Rijsdijk, Fruhling] Kings Coll London, Inst Psychiat Psychol & Neurosci, Social Genet & Dev Res Ctr, London, England.
   [Siribaddana, Sisira] Univ Rajarata, Dept Med, Anuradhapura, Sri Lanka.
   [Zavos, Helena M. S.] Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Psychol, London, England.
   [Sumathipala, Athula] Keele Univ, Fac Med & Hlth Sci, Res Inst Primary Care & Hlth Sci, Keele, Staffs, England.
C3 University of London; King's College London; University of London;
   King's College London; South London & Maudsley NHS Trust; University of
   Sydney; University of London; King's College London; University of
   London; King's College London; Rajarata University of Sri Lanka;
   University of London; King's College London; Keele University
RP Aschan, L (corresponding author), Kings Coll London, Inst Psychiat Psychol & Neurosci, Psychol Med Dept, London, England.; Aschan, L (corresponding author), Kings Coll London, South London & Maudsley NHS Fdn Trust, NIHR Biomed Res Ctr Mental Hlth, London, England.
EM lisa.aschan@kcl.ac.uk
RI Rijsdijk, Fruhling/B-4191-2011; Zunszain, Patricia/HGC-0068-2022;
   Hotopf, Matthew/E-4971-2010; Glozier, Nick/A-7440-2011; Sumathipala,
   Athula/W-2805-2019; Zavos, Helena/B-2153-2013; Siribaddana,
   Sisira/I-2295-2016; Jayaweera, Kaushalya/AAE-7333-2019; Pariante,
   Carmine Maria/B-1297-2011
OI Glozier, Nick/0000-0002-0476-9146; Siribaddana,
   Sisira/0000-0001-5821-2557; Ismail, Khalida/0000-0001-6084-449X;
   Rijsdijk, Fruhling/0000-0003-4762-2803; Hotopf,
   Matthew/0000-0002-3980-4466; Jayaweera, Kaushalya/0000-0003-3780-0901;
   Pariante, Carmine Maria/0000-0002-9132-5091; Zunszain,
   Patricia/0000-0001-8853-5680; Zavos, Helena/0000-0001-8165-6877
FU Wellcome Trust [093206/Z/10/Z]; National Institute for Health Research
   (NIHR) Mental Health Biomedical Research Centre at South London and
   Maudsley NHS Foundation Trust and King's College London; NHMRC of
   Australia [566529, 571421]; Wellcome Trust [093206/Z/10/Z] Funding
   Source: Wellcome Trust; MRC [G108/603, MR/N029488/1] Funding Source:
   UKRI
FX This study was supported by the Wellcome Trust (Grant number:
   093206/Z/10/Z). LA, MH, CMP and PAZ currently receive salary support
   from the National Institute for Health Research (NIHR) Mental Health
   Biomedical Research Centre at South London and Maudsley NHS Foundation
   Trust and King's College London. The sleep substudy of COTASS-2 led by
   NG was supported by the NHMRC of Australia (Grant numbers: 566529 and
   571421). The views expressed are those of the authors and not
   necessarily those of the Wellcome Trust, the NHS, the NIHR or the
   Department of Health. The funders did not have a role in the study
   design; collection, analysis or interpretation of data; the writing of
   the manuscript; or in the decision to submit the manuscript for
   publication.
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NR 77
TC 15
Z9 15
U1 0
U2 2
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1471-2458
J9 BMC PUBLIC HEALTH
JI BMC Public Health
PD JAN 17
PY 2018
VL 18
AR 145
DI 10.1186/s12889-017-4992-2
PG 15
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA FT0RY
UT WOS:000422836800001
PM 29343229
OA Green Published, gold, Green Accepted
DA 2025-06-11
ER

PT J
AU Yalameha, B
   Nejabati, HR
   Nouri, M
AF Yalameha, Banafsheh
   Nejabati, Hamid Reza
   Nouri, Mohammad
TI Circulating microparticles as indicators of cardiometabolic risk in PCOS
SO CLINICA CHIMICA ACTA
LA English
DT Article
DE Polycystic ovary syndrome; Circulating microparticles; Cardiometabolic
   risk factors
ID POLYCYSTIC-OVARY-SYNDROME; PLATELET-DERIVED MICROPARTICLES;
   CARDIOVASCULAR-DISEASE RISK; CORONARY-HEART-DISEASE; METABOLIC SYNDROME;
   ENDOTHELIAL MICROPARTICLES; OXIDATIVE STRESS; OVERWEIGHT/OBESE WOMEN;
   YOUNG-WOMEN; ASSOCIATION
AB Polycystic ovary syndrome (PCOS), the most prevalent endocrine disturbance of the female reproductive system, is associated with several pathologic conditions, such as metabolic syndrome, obesity, diabetes, dyslipidemia, and insulin resistance, all of which are tightly connected to its progression. These factors are associated with a type of extracellular vesicle, ie, microparticles (MPs), released by shedding due to cell activation and apoptosis. Circulating MPs (cMPs) are secreted by a variety of cells, such as platelets, endothelial, leukocytes, and eryth-rocytes, and contain cytoplasmic substances derived from parent cells that account for their biologic activity. Current evidence has clearly shown that increased cMPs contribute to endothelial dysfunction, diabetes, hypertriglyceridemia, metabolic syndrome, cardiovascular abnormalities as well as PCOS. It has also been re -ported that platelet and endothelial MPs are specifically increased in PCOS thus endangering vascular health and subsequent cardiovascular disease. Given the importance of cMPs in the pathophysiology of PCOS, we review the role of cMPs in PCOS with a special focus on cardiometabolic significance.
C1 [Yalameha, Banafsheh] Tabriz Univ Med Sci, Fac Med, Dept Biochem & Clin Labs, Tabriz, Iran.
   [Nejabati, Hamid Reza] Tabriz Univ Med Sci, Stem Cell Res Ctr, Tabriz, Iran.
   [Nouri, Mohammad] Tabriz Univ Med Sci, Fac Adv Med Sci, Dept Reprod Biol, Tabriz, Iran.
C3 Tabriz University of Medical Science; Tabriz University of Medical
   Science; Tabriz University of Medical Science
RP Nejabati, HR (corresponding author), Tabriz Univ Med Sci, Stem Cell Res Ctr, Tabriz, Iran.; Nouri, M (corresponding author), Tabriz Univ Med Sci, Fac Adv Med Sci, Dept Reprod Biol, Tabriz, Iran.
EM nejabati_hr@yahoo.com; nourimd@yahoo.com
RI Yalameha, Banafsheh/AAG-5022-2019; nouri, mohammad/HSB-4293-2023
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NR 129
TC 3
Z9 3
U1 0
U2 9
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0009-8981
EI 1873-3492
J9 CLIN CHIM ACTA
JI Clin. Chim. Acta
PD AUG 1
PY 2022
VL 533
BP 63
EP 70
DI 10.1016/j.cca.2022.06.019
PG 8
WC Medical Laboratory Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Medical Laboratory Technology
GA 2T5PY
UT WOS:000822527700006
PM 35718107
DA 2025-06-11
ER

PT J
AU Finn, DP
AF Finn, David P.
TI Endocannabinoid-mediated modulation of stress responses: Physiological
   and pathophysiological significance
SO IMMUNOBIOLOGY
LA English
DT Article
DE 2-arachidonoylglycerol; Anandamide; Anxiety; Cannabinoid; Depression;
   HPA axis; Stress
ID CANNABINOID CB1 RECEPTOR; PITUITARY-ADRENAL AXIS; ACID AMIDE HYDROLASE;
   ANXIETY-LIKE BEHAVIOR; DORSOLATERAL PERIAQUEDUCTAL GRAY;
   CORTICOTROPIN-RELEASING-FACTOR; CARDIOMETABOLIC RISK-FACTORS;
   ANTIDEPRESSANT-LIKE ACTIVITY; FEAR-CONDITIONED ANALGESIA; IMMUNE-SYSTEM
AB The stress response is associated with a broad spectrum of physiological and behavioural effects including hypothalamo-pituitary-adrenal (HPA) axis activation, altered central nervous system activity, neuroimmune alterations, anxiety- and depressive-like behaviour and analgesia. While the acute stress response has essential survival value, chronic stress and dysfunction of the stress response can be maladaptive, contributing to the development and severity of psychiatric and pain disorders. The endogenous cannabinoid (endocannabinoid) system has emerged as an important lipid signalling system playing a key role in mediating and/or modulating behavioural, neurochemical, neuroendocrine, neuroimmune and molecular responses to stress. The weight of evidence, reviewed here, points largely to a system which serves to constrain HPA axis activity, facilitate adaptation or habituation of HPA axis and behavioural responses to stress, reduce anxiety- and depressive-like behaviour and mediate analgesic responses to unconditioned or conditioned stress. Possible involvement of the immune system and associated signalling molecules (e.g. cytokines) in endocannabinoid-mediated modulation of neuroendocrine and behavioural responses to stress is considered. The goal now should be to exploit our understanding of the role of the endocannabinoid system in fundamental stress physiology and pathophysiological processes to better understand and treat a range of stress-related disorders including anxiety, depression and pain. (C) 2009 Elsevier GmbH. All rights reserved.
C1 [Finn, David P.] Natl Univ Ireland, NCBES Neurosci Cluster, Dept Pharmacol & Therapeut, Galway, Ireland.
   [Finn, David P.] Natl Univ Ireland, Ctr Pain Res, Galway, Ireland.
C3 Ollscoil na Gaillimhe-University of Galway; Ollscoil na
   Gaillimhe-University of Galway
RP Finn, DP (corresponding author), Natl Univ Ireland, NCBES Neurosci Cluster, Dept Pharmacol & Therapeut, Univ Rd, Galway, Ireland.
EM david.finn@nuigalway.ie
OI Finn, David/0000-0001-6186-621X
FU Science Foundation Ireland
FX This work was supported by a grant from Science Foundation Ireland.
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NR 209
TC 65
Z9 73
U1 0
U2 12
PU ELSEVIER GMBH
PI MUNICH
PA HACKERBRUCKE 6, 80335 MUNICH, GERMANY
SN 0171-2985
J9 IMMUNOBIOLOGY
JI Immunobiology
PD AUG
PY 2010
VL 215
IS 8
BP 629
EP 646
DI 10.1016/j.imbio.2009.05.011
PG 18
WC Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology
GA 640JR
UT WOS:000281048000007
PM 19616342
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Mrowietz, U
   Sümbül, M
   Gerdes, S
AF Mrowietz, U.
   Suembuel, M.
   Gerdes, S.
TI Depression, a major comorbidity of psoriatic disease, is caused by
   metabolic inflammation
SO JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
LA English
DT Review; Early Access
ID ASSOCIATION; USTEKINUMAB; ARTHRITIS; DISORDER; SMOKING; PHASE-3; IMMUNE;
   IMPACT; RISK
AB Psoriatic disease is a chronic, systemic immune-mediated inflammatory disorder comprising three major domains, skin, vascular and bone/joint inflammation. It is known for a long time that psoriatic disease is associated with a number of conditions such as hypertension, dyslipidemia, diabetes (metabolic syndrome) and depression. Up to one out of five people with psoriasis show concomitant depression. In the past, this was attributed to psychological stress of suffering from a chronic condition that is often visible and itchy, leading to stigmatization and adding to a significant burden of disease. Recent data provide evidence that depression associated with psoriatic disease is linked to the specific inflammatory pattern with IL-23, IL-17 family cytokines, TNF, IL-6 and IL-8 causing neuroinflammation and subsequently depression or depressive behaviour and/or anxiety. Psoriatic disease shows a distinct pattern of immune cells (e.g. dendritic cells, Th17 cells, neutrophils), mediators (e.g. IL-17A/F, IL-23, TNF) and tissue-related factors in all major domains that is different from other inflammatory dermatoses. There is a striking similarity between the inflammatory pattern in psoriatic disease and neuroinflammation that leads to depression. A number of risk factors have been identified in psoriatic disease, the most important of which are obesity and tobacco smoking. Obesity is known as a major risk factor for depression and anxiety due to its inflammatory signature. Apart from psychotherapy and anti-depressive medication, targeted treatments for psoriasis, including TNF, IL-17 and IL-23 inhibitors, can improve depression/depressive symptoms. The review summarizes the current knowledge about depression as a comorbidity in psoriatic disease.
C1 [Mrowietz, U.; Suembuel, M.; Gerdes, S.] Univ Med Ctr Schleswig Holstein, Psoriasis Ctr, Dept Dermatol, Kiel, Germany.
   [Mrowietz, U.] Univ Med Ctr Schleswig Holstein, Dept Dermatol, Psoriasis Ctr, Campus Kiel,Arnold Heller Str 3,Bldg U27, D-24105 Kiel, Germany.
C3 University of Kiel; Schleswig Holstein University Hospital; University
   of Kiel; Schleswig Holstein University Hospital
RP Mrowietz, U (corresponding author), Univ Med Ctr Schleswig Holstein, Dept Dermatol, Psoriasis Ctr, Campus Kiel,Arnold Heller Str 3,Bldg U27, D-24105 Kiel, Germany.
EM umrowietz@dermatology.uni-kiel.de
RI Sümbül, Melike/AAL-4100-2021; mrowietz, ulrich/B-1645-2010; Gerdes,
   Sascha/J-4308-2017
OI mrowietz, ulrich/0000-0002-9539-0712; Gerdes,
   Sascha/0000-0002-6667-7757; Sumbul, Melike/0000-0002-7845-8236
FU Projekt DEAL
FX Open Access funding enabled and organized by Projekt DEAL.
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NR 64
TC 35
Z9 35
U1 0
U2 16
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0926-9959
EI 1468-3083
J9 J EUR ACAD DERMATOL
JI J. Eur. Acad. Dermatol. Venereol.
PD 2023 JUN 2
PY 2023
DI 10.1111/jdv.19192
EA JUN 2023
PG 8
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA I0UL2
UT WOS:001000012300001
PM 37184282
OA hybrid
DA 2025-06-11
ER

PT J
AU Qiu, WX
   Cai, XD
   Zheng, CH
   Qiu, SM
   Ke, HY
   Huang, YQ
AF Qiu, Wenxin
   Cai, Xiaodan
   Zheng, Chenhui
   Qiu, Shumin
   Ke, Hanyang
   Huang, Yinqiong
TI Update on the Relationship Between Depression and Neuroendocrine
   Metabolism
SO FRONTIERS IN NEUROSCIENCE
LA English
DT Review
DE depression; metabolic syndrome; major depressive disorder; inflammation;
   endocrine
ID NF-KAPPA-B; TYPE-2 DIABETES-MELLITUS; ANXIETY-LIKE BEHAVIOR; CHRONIC
   STRESS; IMMUNE-SYSTEM; INFLAMMASOME ACTIVATION; NEUROTROPHIC FACTOR;
   INSULIN-RESISTANCE; MAJOR DEPRESSION; GLUTAMATE UPTAKE
AB Through the past decade of research, the correlation between depression and metabolic diseases has been noticed. More and more studies have confirmed that depression is comorbid with a variety of metabolic diseases, such as obesity, diabetes, metabolic syndrome and so on. Studies showed that the underlying mechanisms of both depression and metabolic diseases include chronic inflammatory state, which is significantly related to the severity. In addition, they also involve endocrine, immune systems. At present, the effects of clinical treatments of depression is limited. Therefore, exploring the co-disease mechanism of depression and metabolic diseases is helpful to find a new clinical therapeutic intervention strategy. Herein, focusing on the relationship between depression and metabolic diseases, this manuscript aims to provide an overview of the comorbidity of depression and metabolic.
C1 [Qiu, Wenxin; Cai, Xiaodan; Zheng, Chenhui; Qiu, Shumin; Ke, Hanyang] Fujian Med Univ, Fuzhou, Fujian, Peoples R China.
   [Huang, Yinqiong] Fujian Med Univ, Affiliated Hosp 2, Dept Endocrinol, Quanzhou, Peoples R China.
C3 Fujian Medical University; Fujian Medical University
RP Huang, YQ (corresponding author), Fujian Med Univ, Affiliated Hosp 2, Dept Endocrinol, Quanzhou, Peoples R China.
EM yinqiongh@fjmu.edu.cn
RI Huang, Yinqiong/HGI-8085-2022
OI Huang, Yinqiong/0000-0001-9186-3896
FU College Student Innovation and Entrepreneurship Training Program, Fujian
   Medical University [C20009]
FX We thank the support from College Student Innovation and
   Entrepreneurship Training Program, Fujian Medical University (C20009).
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NR 151
TC 44
Z9 45
U1 1
U2 20
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1662-453X
J9 FRONT NEUROSCI-SWITZ
JI Front. Neurosci.
PD AUG 31
PY 2021
VL 15
AR 728810
DI 10.3389/fnins.2021.728810
PG 13
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology
GA UT3MQ
UT WOS:000698024300001
PM 34531719
OA Green Published, gold
DA 2025-06-11
ER

PT S
AU Kramer, A
AF Kramer, Andreas
BE Xiao, J
TI An Overview of the Beneficial Effects of Exercise on Health and
   Performance
SO PHYSICAL EXERCISE FOR HUMAN HEALTH
SE Advances in Experimental Medicine and Biology
LA English
DT Article; Book Chapter
DE Physical activity; Physical performance; Exercise; Medicine; Public
   health
ID BONE-MINERAL DENSITY; HIGH-IMPACT EXERCISE; RANDOMIZED CONTROLLED-TRIAL;
   CROSS-SECTIONAL AREA; PHYSICAL-ACTIVITY; HIGH-INTENSITY; METABOLIC
   SYNDROME; MENTAL-HEALTH; RESISTANCE EXERCISE; RISK-FACTORS
AB Life expectancy is steadily increasing in modern societies, and so are noncommunicable diseases such as cardiovascular diseases, diabetes, obesity, and cancer, accounting for more than 70% of all deaths globally. The costs associated with these diseases are enormous, but it has been estimated that the majority of these noncommunicable diseases are preventable. In addition to an unhealthy diet, tobacco use, and harmful use of alcohol, physical inactivity is a key risk factor. Consequently, physical activity is a logical remedy, and in this chapter an overview of the numerous beneficial effects of physical activity on health and performance is given.
   The chapter is divided into three parts: First, the basics of physical activity and exercise are discussed, for instance exercise classification, exercise intensity operationalization, energy supply, and the acute effects of exercise such as blood flow redistribution and increased cardiac output. In the second part, the effects of exercise on physical performance are summarized. Specifically, it is discussed how endurance, strength, power, and balance can be improved. This discussion includes recommendations regarding the type, intensity, and duration of the exercise leading to improvements in one of these aspects of physical performance, as well as the mechanisms causing these adaptations. In the third part, the beneficial effects of physical activity on physical and mental health are outlined, with particular attention to cardiovascular diseases, the metabolic syndrome, musculoskeletal diseases, mood, anxiety, depression, and dementia.
   It can be concluded that with adequate programming, regular physical activity is an effective way to improve physical performance, improve physical and mental health, and reduce the risk factors for many noncommunicable diseases such as cardiovascular diseases, metabolic syndrome, sarcopenia, osteoporosis, and depression. In contrast to medication, physical exercise has no negative side effects, costs very little, and targets many health issues at once. If the multitude of beneficial effects of regular exercise were to be combined in a single low-cost drug, it would be prescribed for almost all types of physical and mental health issues.
C1 [Kramer, Andreas] Univ Konstanz, Dept Sport Sci, Sensorimotor Performance Lab, Constance, Germany.
   [Kramer, Andreas] Univ Konstanz, FG Sports Sci, Constance, Germany.
C3 University of Konstanz; University of Konstanz
RP Kramer, A (corresponding author), Univ Konstanz, Dept Sport Sci, Sensorimotor Performance Lab, Constance, Germany.; Kramer, A (corresponding author), Univ Konstanz, FG Sports Sci, Constance, Germany.
EM andreas.kramer@uni-konstanz.de
RI Kramer, Andreas/AAJ-1837-2020
OI Kramer, Andreas/0000-0002-2586-5508
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NR 175
TC 57
Z9 66
U1 5
U2 57
PU SPRINGER-VERLAG SINGAPORE PTE LTD
PI SINGAPORE
PA 152 BEACH ROAD, #21-01/04 GATEWAY EAST, SINGAPORE, 189721, SINGAPORE
SN 0065-2598
EI 2214-8019
BN 978-981-15-1792-1; 978-981-15-1791-4
J9 ADV EXP MED BIOL
JI Adv.Exp.Med.Biol.
PY 2020
VL 1228
BP 3
EP 22
DI 10.1007/978-981-15-1792-1_1
D2 10.1007/978-981-15-1792-1
PG 20
WC Medicine, Research & Experimental; Physiology; Sport Sciences
WE Book Citation Index – Science (BKCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Physiology; Sport Sciences
GA BQ5AS
UT WOS:000596720900001
PM 32342447
DA 2025-06-11
ER

PT J
AU Kaye, S
   Lewandowski, A
   Dunne, M
   Bowman, J
   Archer, V
AF Kaye, Sharlene
   Lewandowski, Amy
   Dunne, Mitchell
   Bowman, Julia
   Archer, Vicki
TI Feasibility of an Intervention Targeting Health through Exergaming as an
   Alternative to Routine Treatment (FIT HEART): protocol for a
   non-randomised two-armed pilot study
SO PILOT AND FEASIBILITY STUDIES
LA English
DT Article
DE Exergaming; Active videogaming; Physical activity intervention; Mental
   health; Inpatient; Cardiovascular; Cardiometabolic risk
ID PHYSICAL-ACTIVITY; MENTAL-ILLNESS; OXYGEN-UPTAKE; OLDER-ADULTS; VIDEO
   GAMES; WEIGHT-GAIN; PROGRAM; FITNESS; METAANALYSIS; VALIDATION
AB Background: Despite elevated risk of cardiometabolic disease among those with serious mental illness, and wide-spread recognition that physical activity interventions are required, there are multiple barriers to implementing typically recommended physical activity programmes in secure inpatient settings. Due to low mood, negative symptoms and poor socio-occupational functioning, psychiatric inpatients often lack motivation to engage in physical activity programmes. Moreover, regular access to outdoor spaces and exercise equipment is limited. As such, there is a need for novel physical activity interventions that are suitable for secure settings. This study aims to investigate the feasibility, acceptability and potential effectiveness of an intervention (exergaming) to promote physical activity among patients in a secure mental health setting.
   Methods: This non-randomised, two-arm pilot study will employ a pre-test/post-test parallel group design, comparing the exergaming intervention with a "routine treatment" control. Two high-secure, sub-acute wards in the Long Bay Hospital Mental Health Unit will be non-randomly allocated to either the exergaming intervention or the "routine treatment" control group.
   The intervention group will receive a 12-week programme comprising three 30-min exergaming sessions per week using various Xbox Kinect (TM) activity-based games designed to simulate moderate intensity exercise. The "routine treatment" group will continue to receive the standard model of care delivered by the Justice Health and Forensic Mental Health Network. Accelerometers will be distributed to all participants to collect daily energy expenditure, number of steps taken, intensity of physical activity and heart rate data throughout the study.
   The primary outcomes are (1) intervention feasibility and acceptability, and (2) baseline to post-intervention changes in physical health outcomes (levels of physical activity; cardiovascular fitness; clinical measures of cardiometabolic risk). Secondary outcomes are baseline to post-intervention changes in mental health outcomes (depression, anxiety, stress, positive psychiatric symptoms). Outcomes will be assessed at baseline, mid-intervention, and post-intervention.
   Discussion: This research will contribute to evidence-based practice in the care of patients with serious mental illness: a vulnerable population with complex physical and mental health needs and a markedly elevated risk of cardiovascular disease. The findings will inform cardiovascular health promotion strategies and the implementation of physical activity interventions in secure inpatient settings.
C1 [Kaye, Sharlene; Lewandowski, Amy; Dunne, Mitchell; Bowman, Julia; Archer, Vicki] Justice Hlth & Forens Mental Hlth Network, Res Unit, Long Bay Complex,Roundhouse,1300 Anzac Parade, Malabar, NSW 2036, Australia.
   [Kaye, Sharlene] UNSW Sydney, Natl Drug & Alcohol Res Ctr, Sydney, NSW, Australia.
C3 University of New South Wales Sydney
RP Kaye, S (corresponding author), Justice Hlth & Forens Mental Hlth Network, Res Unit, Long Bay Complex,Roundhouse,1300 Anzac Parade, Malabar, NSW 2036, Australia.; Kaye, S (corresponding author), UNSW Sydney, Natl Drug & Alcohol Res Ctr, Sydney, NSW, Australia.
EM Sharlene.Goodhew@health.nsw.gov.au
RI Kaye, Sharlene/A-3815-2012; Lewandowski, Amy/JTT-6199-2023
OI Kaye, Sharlene/0000-0002-7657-5105
FU NSW Health Translational Research Grant Scheme, Office for Health and
   Medical Research, NSW Ministry of Health, Australia
FX This study was funded through NSW Health Translational Research Grant
   Scheme, Office for Health and Medical Research, NSW Ministry of Health,
   Australia. The funding body had no role in the design of the study,
   preparation of this manuscript, or decision to publish.
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NR 45
TC 1
Z9 1
U1 1
U2 3
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 2055-5784
J9 PILOT FEASIBILITY ST
JI Pilot Feasibility Stud.
PD JUN 11
PY 2022
VL 8
IS 1
AR 122
DI 10.1186/s40814-022-01068-2
PG 14
WC Medicine, Research & Experimental
WE Emerging Sources Citation Index (ESCI)
SC Research & Experimental Medicine
GA 2B7RA
UT WOS:000810380400001
PM 35690876
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Ross, A
   Shamburek, R
   Wehrlen, L
   Klagholz, SD
   Yang, L
   Stoops, E
   Flynn, SL
   Remaley, AT
   Pacak, K
   Shelburne, N
   Bevans, MF
AF Ross, Alyson
   Shamburek, Robert
   Wehrlen, Leslie
   Klagholz, Stephen D.
   Yang, Li
   Stoops, Elyssa
   Flynn, Sharon L.
   Remaley, Alan T.
   Pacak, Karel
   Shelburne, Nonniekaye
   Bevans, Margaret F.
TI Cardiometabolic risk factors and health behaviors in family caregivers
SO PLOS ONE
LA English
DT Article
ID NUCLEAR-MAGNETIC-RESONANCE; INTIMA-MEDIA THICKNESS;
   CORONARY-HEART-DISEASE; TERM-FOLLOW-UP; METABOLIC SYNDROME; CHRONIC
   STRESS; ASSOCIATION; FRAMINGHAM; MORTALITY; PATIENT
AB The purpose of this study was to compare components of cardiometabolic risk and health behaviors of 20 family caregivers of allogeneic hematopoietic stem cell transplant patients to those of age, gender, and race/ethnicity-matched controls. A prospective, repeated measures design was used to compare cardiometabolic risk and health behaviors in caregivers and controls at three time-points: pre-transplantation, discharge, and six weeks post-discharge. Measures included components of metabolic syndrome, Reynolds Risk Score, NMR serum lipoprotein particle analyses, and the Health-Promoting Lifestyle Profile II (HPLP-II). Mixed-model repeated measure analyses were used. There were no between or within group differences in LDL cholesterol, HDL cholesterol, and triglycerides. There was a significant interaction effect between time and role in large VLDL concentration (VLDL-P) (F (2, 76) = 4.36, p = .016), with the trajectory of large VLDL-P increasing over time in caregivers while remaining stable in controls. Within care-givers, VLDL particle size (VLDL-Z) was significantly larger at time-point three compared to time-points one (p = .015) and two (p = .048), and VLDL-Z was significantly larger in caregivers than in controls at time point three (p = .012). HPLP-II scores were lower in caregivers than controls at all time-points (p < .01). These findings suggest that caregiving may have a bigger impact on triglycerides than on other lipids, and it is through this pathway that caregivers may be at increased cardiometabolic risk. More sensitive measurement methods, such as NMR lipoprotein particle analyses, may be able to detect early changes in cardiometabolic risk.
C1 [Ross, Alyson; Wehrlen, Leslie; Klagholz, Stephen D.; Yang, Li; Stoops, Elyssa; Flynn, Sharon L.; Bevans, Margaret F.] NIH, Ctr Clin, Dept Nursing, Bethesda, MD 20892 USA.
   [Shamburek, Robert] NHLBI, NIH, Bldg 10, Bethesda, MD 20892 USA.
   [Remaley, Alan T.] NIH, Ctr Clin, Dept Lab Med, Bethesda, MD 20892 USA.
   [Pacak, Karel] NICHHD, NIH, Bethesda, MD 20892 USA.
   [Shelburne, Nonniekaye] NCI, NIH, Bethesda, MD 20892 USA.
C3 National Institutes of Health (NIH) - USA; NIH Clinical Center (CC);
   National Institutes of Health (NIH) - USA; NIH National Heart Lung &
   Blood Institute (NHLBI); National Institutes of Health (NIH) - USA; NIH
   Clinical Center (CC); National Institutes of Health (NIH) - USA; NIH
   Eunice Kennedy Shriver National Institute of Child Health & Human
   Development (NICHD); National Institutes of Health (NIH) - USA; NIH
   National Cancer Institute (NCI)
RP Ross, A (corresponding author), NIH, Ctr Clin, Dept Nursing, Bethesda, MD 20892 USA.
EM alyson.ross@nih.gov
RI Klagholz, Stephen/M-4119-2019; Yang, Li/KMG-3813-2024
OI Yang, Li/0000-0002-4513-872X
FU Intramural Research Program at the National Institutes of Health
   [11-CC-0265]
FX This research was funded by the Intramural Research Program at the
   National Institutes of Health, Clinical Center 11-CC-0265 "A pilot study
   to examine physiological and clinical markers of chronic stress in
   caregivers of allogeneic hematopoietic stem cell transplant (HSCT)
   recipients".
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NR 43
TC 10
Z9 11
U1 0
U2 11
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAY 4
PY 2017
VL 12
IS 5
AR e0176408
DI 10.1371/journal.pone.0176408
PG 15
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Science & Technology - Other Topics
GA ET9SP
UT WOS:000400648500045
PM 28472106
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Shinkov, A
   Borissova, AM
   Kovatcheva, R
   Vlahov, J
   Dakovska, L
   Atanassova, I
   Petkova, P
AF Shinkov, Alexander
   Borissova, Anna-Maria
   Kovatcheva, Roussanka
   Vlahov, Jordan
   Dakovska, Lilia
   Atanassova, Iliana
   Petkova, Paulina
TI Increased prevalence of depression and anxiety among subjects with
   metabolic syndrome and known type 2 diabetes mellitus - a
   population-based study
SO POSTGRADUATE MEDICINE
LA English
DT Article
DE Diabetes mellitus; metabolic syndrome; Zung self-rating scale;
   depression; anxiety; SASi; SDSi
ID MAJOR DEPRESSION; RISK-FACTORS; CARDIOVASCULAR-DISEASE; NATIONAL-HEALTH;
   SYMPTOMS; ASSOCIATION; DISORDER; CORTISOL; WOMEN; AGE
AB Objectives: The metabolic syndrome (MetS) is a cluster of cardiovascular risk factors associated with high cardiovascular morbidity and mortality. The MetS and its elements have been linked to anxiety and depressive disorders. The aim of the current cross-sectional study was to assess the prevalence of depression and anxiety, measured by the Zung Self-Rating Scale in subjects with and without the metabolic syndrome and diabetes.Methods: A total of 2111 adults were included, 1155 female, age 47.6 (13.7) and 956 male, age 45.2 (13.5). All participants filled questionnaires covering current and past disorders and medication, smoking and family history. Zung self-rating depression and anxiety scales were completed. Body weight, height and waist circumference were measured, BMI was calculated, serum glucose and lipids were measured.Results: Depression (SDSi) and anxiety scores (SASi) were higher in the females and increased with age (p<0.001). SDSi was higher in the females and males with metabolic syndrome (MetS) (50.99.8 vs. 45.9 +/- 8.9, p<0.001 and 42.7 +/- 9.2 vs. 40.5 +/- 7.9 p<0.001, respectively). SASi was higher in the MetS subjects (females 50.59 +/- 11.35 vs. 45.97 +/- 10.58, p<0.001; males 40.48 +/- 10.1 vs. 38.04 +/- 8.42, p<0.001). Both SDSi and SASi were higher in the subjects with known diabetes than in those with normal glucose tolerance (Mann-Whitney both p<0,001). Positive depressive scores were more prevalent in subjects with MetS than those without (females 54% vs. 31.6%, p<0.001; males 22.7% vs. 12.3%, p<0.001). Depression and anxiety were more prevalent in the subjects with known diabetes than in those with normal glucose tolerance but not in the newly-diagnosed diabetes. The OR for depressiveness was 2.0 (1.3; 2.6) in subjects with MetS and 4.2 (2.3; 7.8) in those with known diabetes.Conclusions: In conclusion, depressiveness and anxiety were associated positively with age and female gender and were more prevalent among subjects with MetS and known diabetes mellitus.
C1 [Shinkov, Alexander; Borissova, Anna-Maria; Kovatcheva, Roussanka; Vlahov, Jordan; Dakovska, Lilia; Atanassova, Iliana; Petkova, Paulina] Med Univ Sofia, Clin Ctr Endocrinol, 2 Zdrave St, Sofia 1431, Bulgaria.
C3 Medical University Sofia
RP Shinkov, A (corresponding author), Med Univ Sofia, Clin Ctr Endocrinol, 2 Zdrave St, Sofia 1431, Bulgaria.
EM shinkovs@abv.bg
RI Kovatcheva, Roussanka/GQI-3152-2022; Shinkov, Alexander/F-8140-2013
OI Kovatcheva, Roussanka/0000-0003-1894-8433; Shinkov,
   Alexander/0000-0002-9203-4149
FU Bulgarian Society of Endocrinology
FX This paper was supported by the Bulgarian Society of Endocrinology.
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NR 52
TC 48
Z9 48
U1 0
U2 9
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0032-5481
EI 1941-9260
J9 POSTGRAD MED
JI Postgrad. Med.
PY 2018
VL 130
IS 2
BP 251
EP 257
DI 10.1080/00325481.2018.1410054
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA FZ6ZD
UT WOS:000427748200015
PM 29185828
DA 2025-06-11
ER

PT J
AU Perez, CSDH
   Ciufolini, S
   Sood, PG
   Krivoy, A
   Young, AH
   Murray, RM
   Ismail, K
   Atakan, Z
   Greenwood, K
   Smith, S
   Gaughran, F
   Juruena, MF
AF Perez, C. S. D. H.
   Ciufolini, Simone
   Sood, Poonam Gardner
   Krivoy, Amir
   Young, Allan H.
   Murray, Robin M.
   Ismail, Khalida
   Atakan, Zerrin
   Greenwood, Kathryn
   Smith, Shubulade
   Gaughran, Fiona
   Juruena, Mario F.
TI Predictive value of cardiometabolic biomarkers and depressive symptoms
   for symptom severity and quality of life in patients with psychotic
   disorders
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
ID METABOLIC SYNDROME; NEGATIVE SYMPTOMS; BIPOLAR DISORDER; RISK-FACTORS;
   SCHIZOPHRENIA; PEOPLE; PREVALENCE; ANTIPSYCHOTICS; ASSOCIATION; ANXIETY
AB Background: Patients with psychotic disorders show higher rates of the metabolic syndrome (MS) between the cluster of severe mental illnesses. Depressive symptoms can worsen outcomes of individuals with psychotic disorders. However, research on the association between MS and depression in psychotic disorders and their relevance to outcomes is lacking.
   Methods: We investigated the association between depression and cardiometabolic biomarkers in psychotic disorders and the predictive value of depressive symptoms on psychopathological severity and quality of life (QoL). 406 patients with psychotic disorders were recruited as part of the Improving Physical Health and Reducing Substance Use in Severe Mental Illness randomised controlled trial. Depression, psychotic symptoms, QoL, waist circumference, triglycerides, high-density lipoprotein cholesterol (HDL-C), blood pressure, and fasting glucose of patients were assessed at baseline and 12 months. Sensitivity analyses were conducted to test the effect of treatment.
   Results: More severe baseline symptoms of depression significantly predicted worse 12-month psychotic symptoms and lower mental health related QoL at 12 months. These associations held after controlling for alcohol use, gender, ethnicity, education, and mental health related QoL Baseline. Depressive symptoms also correlated with waist circumference at both baseline and 12 months, after controlling for multiple testing.
   Conclusion: Individuals with psychotic disorders experiencing more severe depressive symptoms are more likely to have larger waist circumference contemporaneously and 12 months later, as well as more severe psychotic symptoms and worse QoL at follow-up. This highlights the need for evaluation of strategies to address depression in the management of psychotic disorders.
C1 [Perez, C. S. D. H.; Krivoy, Amir] Kings Coll London, Inst Psychiat Psychol & Neurosci, London, England.
   [Ciufolini, Simone] Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Psychosis Studies, London, England.
   [Sood, Poonam Gardner] UCL, London, England.
   [Krivoy, Amir] Tel Aviv Univ, Sackler Fac Med, Ramat Aviv, Israel.
   [Young, Allan H.] Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Psychol Med, Ctr Affect Disorders, London, England.
   [Murray, Robin M.] Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Psychosis Studies, London, England.
   [Ismail, Khalida] Kings Coll London, Psychiat & Med, Dept Psychol Med, Inst Psychiat Psychol & Neurosci, Denmark Hill, London, England.
   [Atakan, Zerrin] Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Psychosis Studies, London, England.
   [Greenwood, Kathryn] Univ Sussex, Sussex Partnership NHS Fdn Trust, Falmer, England.
   [Greenwood, Kathryn] Univ Sussex, Sch Psychol, Falmer, England.
   [Smith, Shubulade] Kings Coll London, Dept Forens & Neurodev Sci, Inst Psychiat Psychol & Neurosci, Denmark Hill, London, England.
   [Gaughran, Fiona] Kings Coll London, Natl Psychosis Serv, South London & Maudsley NHS Fdn Trust, Denmark Hill, London, England.
   [Gaughran, Fiona] Kings Coll London, Dept Psychosis Studies, Inst Psychiat Psychol & Neurosci, Denmark Hill, London, England.
   [Juruena, Mario F.] Kings Coll London, Maudsley Adv Treatment Serv, South London & Maudsley NHS Fdn Trust, London, England.
   [Juruena, Mario F.] Kings Coll London, Translat Psychiat, Dept Psychol Med, Ctr Affect Disorders,Inst Psychiat,Psychol & Neur, London, England.
   [Ciufolini, Simone] South London & Maudsley NHS Fdn Trust London, Natl Inst Hlth Res NIHR, Mental Hlth Biomed Res Ctr, London, England.
   [Ciufolini, Simone] Kings Coll London, London, England.
   [Krivoy, Amir] South London & Maudsley NHS Fdn Trust London, Natl Psychosis Unit, Bethlem Royal Hosp, London, England.
   [Young, Allan H.; Murray, Robin M.] South London & Maudsley NHS Fdn Trust, London, England.
   [Murray, Robin M.] Univ Palermo, Dept Psychiat Expt Biomed & Clin Neurosci BIONEC, Palermo, Italy.
   [Smith, Shubulade] South London & Maudsley NHS Fdn Trust, Forens Serv, London, England.
C3 University of London; King's College London; University of London;
   King's College London; University of London; University College London;
   Tel Aviv University; Sackler Faculty of Medicine; University of London;
   King's College London; University of London; King's College London;
   University of London; King's College London; University of London;
   King's College London; University of Sussex; University of Sussex;
   University of London; King's College London; University of London;
   King's College London; University of London; King's College London;
   South London & Maudsley NHS Trust; University of London; King's College
   London; University of London; King's College London; University of
   London; King's College London; South London & Maudsley NHS Trust;
   Bethlem Royal Hospital; South London & Maudsley NHS Trust; University of
   Palermo; South London & Maudsley NHS Trust
RP Juruena, MF (corresponding author), KCL, IoPPN, PO72,Room M3.24,16 Crespigny Pk Denmark Hill, London SE5 8AF, England.
EM Mario.Juruena@kcl.ac.uk
RI Gaughran, Fiona/AAC-7160-2019; Juruena, Mario/AAM-4622-2020; greenwood,
   kathryn/I-8638-2012; Gaughran, Fiona/H-5495-2011; murray,
   robin/F-8658-2012
OI Gaughran, Fiona/0000-0001-7414-5569; murray, robin/0000-0003-0829-0519;
   Greenwood, Kathryn/0000-0001-7899-8980; Smith,
   Shubulade/0000-0002-3797-6985; Young, Allan/0000-0003-2291-6952; Ismail,
   Khalida/0000-0001-6084-449X; Pereira Juruena, Mario
   Francisco/0000-0001-8558-3396
FU National Institute for Health Research (NIHR) under its IMPACT Programme
   [RP-PG-0606-1049]; Genetics and Psychosis Project - National Institute
   for Health Research (NIHR) Biomedical Research Centre at South London
   and Maudsley NHS Foundation Trust and King's College London; National
   Institute for Health Research's (NIHR) Biomedical Research Centre at
   South London and Maudsley NHS Foundation Trust and King's College
   London; Maudsley Charity; National Institute for Health Research (NIHR)
   Applied Research Collaboration South London (NIHR ARC South London) at
   King's College Hospital NHS Foundation Trust; National Institute for
   Health Research (NIHR) Biomedical Research Centre at South London and
   Maudsley NHS Foundation Trust and King's College London; National
   Institute for Health Research (NIHR) Biomedical Research Centre at South
   London Maudsley NHS Foundation Trust (SLaM); King's College London; SLaM
FX This paper summarises independent research funded by the National
   Institute for Health Research (NIHR) under its IMPACT Programme (Grant
   Reference Number RP-PG-0606-1049) in collaboration with Genetics and
   Psychosis Project funded by the National Institute for Health Research
   (NIHR) Biomedical Research Centre at South London and Maudsley NHS
   Foundation Trust and King's College London. FG is in part supported by
   the National Institute for Health Research's (NIHR) Biomedical Research
   Centre at South London and Maudsley NHS Foundation Trust and King's
   College London, the Maudsley Charity and the National Institute for
   Health Research (NIHR) Applied Research Collaboration South London (NIHR
   ARC South London) at King's College Hospital NHS Foundation Trust.
   Professor Young's research is funded by the National Institute for
   Health Research (NIHR) Biomedical Research Centre at South London and
   Maudsley NHS Foundation Trust and King's College London. Dr Juruena's
   independent research is funded by the National Institute for Health
   Research (NIHR) Biomedical Research Centre at South London Maudsley NHS
   Foundation Trust (SLaM), King's College London and SLaM. The views
   expressed are those of the authors and not necessarily those of the NHS,
   the NIHR, the Department of Health, or the Department of Health and
   Social Care.
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NR 39
TC 1
Z9 1
U1 0
U2 0
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD FEB 1
PY 2022
VL 298
BP 95
EP 103
DI 10.1016/j.jad.2021.10.038
PN A
PG 9
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA O4QQ6
UT WOS:001043680700012
PM 34699852
DA 2025-06-11
ER

PT J
AU Gulati, OP
AF Gulati, Om P.
TI Pycnogenol® in Metabolic Syndrome and Related Disorders
SO PHYTOTHERAPY RESEARCH
LA English
DT Review
DE Pycnogenol (R); food supplement; metabolic syndrome; obesity;
   dyslipidaemia; diabetes; hypertension; renal dysfunction; clinical
   research
ID PINE BARK EXTRACT; EXPERIMENTAL RENAL-HYPERTENSION; 2-KIDNEY GOLDBLATT
   HYPERTENSION; CARDIOVASCULAR RISK-FACTORS; INSULIN-RESISTANCE SYNDROME;
   TYPE-2 DIABETES-MELLITUS; ENDOTHELIAL FUNCTION; OXIDATIVE STRESS;
   BLOOD-PRESSURE; NITRIC-OXIDE
AB The present review provides an update of the biological actions of Pycnogenol (R) in the treatment of metabolic syndrome and related disorders such as obesity, dyslipidaemia, diabetes and hypertension. Pycnogenol (R) is a French maritime pine bark extract produced from the outer bark of Pinus pinaster Ait. Subsp. atlantica. Its strong antioxidant, antiinflammatory, endothelium-dependent vasodilator activity, and also its anti-thrombotic effects make it appropriate for targeting the multifaceted pathophysiology of metabolic syndrome. Clinical studies have shown that it can reduce blood glucose levels in people with diabetes, blood pressure in mild to moderate hypertensive patients, and waist circumference, and improve lipid profile, renal and endothelial functions in metabolic syndrome. This review highlights the pathophysiology of metabolic syndrome and related clinical research findings on the safety and efficacy of Pycnogenol (R). The results of clinical research studies performed with Pycnogenol (R) are discussed using an evidence-based, target-oriented approach following the pathophysiology of individual components as well as in metabolic syndrome overall. Copyright (c) 2015 John Wiley & Sons, Ltd.
C1 [Gulati, Om P.] Horphag Res, Geneva, Switzerland.
RP Gulati, OP (corresponding author), Chemin Corniche 28, CH-1163 Etoy, Switzerland.
EM o.gulati@bluewin.ch
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NR 129
TC 32
Z9 33
U1 0
U2 31
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0951-418X
EI 1099-1573
J9 PHYTOTHER RES
JI Phytother. Res.
PD JUL
PY 2015
VL 29
IS 7
BP 949
EP 968
DI 10.1002/ptr.5341
PG 20
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA CM7FH
UT WOS:000357855300001
PM 25931421
DA 2025-06-11
ER

PT J
AU Tan, HM
   Tong, SF
   Ho, CCK
AF Tan, Hui Meng
   Tong, Seng Fah
   Ho, Christopher C. K.
TI Men's Health: Sexual Dysfunction, Physical, and Psychological Health-Is
   There a Link?
SO JOURNAL OF SEXUAL MEDICINE
LA English
DT Review
DE Health; Physical; Psychological; Sexual Dysfunction
ID CORONARY-ARTERY-DISEASE; QUALITY-OF-LIFE; MIDDLE-AGED MEN; MALE ERECTILE
   DYSFUNCTION; HORMONE-BINDING GLOBULIN; PITUITARY-GONADAL AXIS; LOW SERUM
   TESTOSTERONE; METABOLIC SYNDROME; RISK-FACTORS; CARDIOVASCULAR-DISEASE
AB Introduction. Sexual dysfunction in men, such as erectile dysfunction, hypogonadism, and premature ejaculation, generates considerable attention. Its association with physical and psychological health is an issue which should be addressed seriously.
   Aim. A review of the literature pertaining to the correlation between sexual dysfunction and physical and psychological health.
   Methods. PubMed search for relevant publications on the association between sexual dysfunction in men and physical and psychological health.
   Main Outcome Measure. Clinical and epidemiological evidence that demonstrates the association between sexual dysfunction in men and physical and psychological health.
   Results. Sexual dysfunction, i.e., erectile dysfunction, hypogonadism, and premature ejaculation, has been shown to be associated with physical and psychological health. There is a strong correlation between sexual dysfunction and cardiovascular disease, metabolic syndrome, quality of life, and depression.
   Conclusion. The association between men's sexual dysfunction and physical and psychological health is real and proven. Therefore, it should not be taken lightly but instead treated as a life-threatening medical problem. Tan HM, Tong SF, and Ho CCK. Men's health: Sexual dysfunction, physical, and psychological health-Is there a link? J Sex Med 2012; 9: 663-671.
C1 [Ho, Christopher C. K.] Univ Kebangsaan Malaysia, Med Ctr, Dept Surg, Kuala Lumpur 56000, Malaysia.
   [Tan, Hui Meng] Sime Darby Med Ctr, Selangor, Malaysia.
   [Tan, Hui Meng] Univ Malaya, Fac Med, Med Res & Dev Unit, Kuala Lumpur, Malaysia.
   [Tan, Hui Meng] Univ Kebangsaan Malaysia, Med Ctr, Dept Family Med, Kuala Lumpur, Malaysia.
C3 Universiti Kebangsaan Malaysia; Universiti Malaya; Universiti Kebangsaan
   Malaysia
RP Ho, CCK (corresponding author), Univ Kebangsaan Malaysia, Med Ctr, Dept Surg, Kuala Lumpur 56000, Malaysia.
EM chrisckho2002@yahoo.com
RI tan, hui/KYP-1763-2024; Tong, Seng/D-4283-2013; Ho,
   Christopher/C-1421-2011
OI seng fah, tong/0000-0002-8725-1536; Ho, Christopher/0000-0002-8757-6867
CR [Anonymous], 2006, Sexual health document series: Defining sexual health report of a technical consultation on sexual health 28-31 January 2002, Geneva
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NR 120
TC 81
Z9 86
U1 1
U2 22
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 1743-6095
J9 J SEX MED
JI J. Sex. Med.
PD MAR
PY 2012
VL 9
IS 3
BP 663
EP 671
DI 10.1111/j.1743-6109.2011.02582.x
PG 9
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Urology & Nephrology
GA 899QR
UT WOS:000300831700003
PM 22188573
DA 2025-06-11
ER

PT J
AU Barzegaran, M
   Jazayeri, S
   Abolghasemi, J
   Hosseinzadeh, M
   Fatemi, SF
   Mirzaei, M
   Salehi-Abargouei, A
AF Barzegaran, Mahdieh
   Jazayeri, Shima
   Abolghasemi, Jamileh
   Hosseinzadeh, Mahdieh
   Fatemi, Seyedeh Fatemeh
   Mirzaei, Masoud
   Salehi-Abargouei, Amin
TI The relationship between dietary lipophilic index and load with
   depression, anxiety, and stress symptoms
SO BMC PSYCHIATRY
LA English
DT Article
DE Lipophilic index; Lipophilic load; Depression; Anxiety; Stress
ID CORONARY-HEART-DISEASE; FATTY-ACID PROFILE; METABOLIC SYNDROME; RISK;
   VALIDITY; FLUIDITY
AB BackgroundDietary fatty acids can affect brain health by modifying neuronal membrane fluidity. Dietary lipophilic index (LI) and load (LL) may be related to cell membrane fluidity. This study aimed to determine the relationship between dietary LI and LL with symptoms of depression, anxiety and stress.MethodsIn this cross-sectional study, taken from the YaHS (Yazd Health Study) population-based cohort, the data of 2,982 individuals was extracted. Several questionnaires- a 178-item Food Frequency Questionnaire (FFQ), Depression, Anxiety and Stress Scale 21 (DASS 21), and International Physical Activity Questionnaire (IPAQ)- were used to obtain information on dietary intake, mental status, and physical activity, respectively. LI and LL were calculated using dietary intake and the melting point of each fatty acid.ResultsThe analysis was performed on 2982 individuals. The odds ratio of depression in the second tertile of dietary LI compared to the first tertile was 0.815 (95% CI 0.66-1.00, P = 0.051, Ptrend = 0.017) and after adjusting confounders was 0.793 (95% CI 0.63-0.99, P = 0.043, Ptrend = 0.011). Also, LL was related inversely with anxiety (0.771, 95% CI 0.63-0.93, P = 0.003) that after multiple regression, OR of anxiety was 0.762 (95% CI 0.53-1.07, P = 0.045). The odds of stress in the third tertile of LL was 1.064 but not statistically significant (95% CI 0.88-1.28, P = 0.729).ConclusionThis study showed an inverse association between dietary LI and depression symptoms. Anxiety and stress did not show a significant relationship with LI or LL.
C1 [Barzegaran, Mahdieh; Jazayeri, Shima] Iran Univ Med Sci, Sch Publ Hlth, Dept Nutr, Tehran, Iran.
   [Abolghasemi, Jamileh] Iran Univ Med Sci, Sch Publ Hlth, Dept Biostat, Tehran, Iran.
   [Hosseinzadeh, Mahdieh; Salehi-Abargouei, Amin] Shahid Sadoughi Univ Med Sci, Sch Publ Hlth, Dept Nutr, Yazd, Iran.
   [Hosseinzadeh, Mahdieh; Mirzaei, Masoud; Salehi-Abargouei, Amin] Shahid Sadoughi Univ Med Sci, Noncommunicable Dis Res Inst, Yazd Cardiovasc Res Ctr, Yazd, Iran.
   [Hosseinzadeh, Mahdieh; Salehi-Abargouei, Amin] Shahid Sadoughi Univ Med Sci, Res Ctr Food Hyg & Safety, Sch Publ Hlth, Yazd, Iran.
   [Fatemi, Seyedeh Fatemeh] Mashhad Univ Med Sci, Fac Med, Dept Nutr, Mashhad, Iran.
C3 Iran University of Medical Sciences; Iran University of Medical
   Sciences; Shahid Sadoughi University of Medical Sciences; Shahid
   Sadoughi University of Medical Sciences; Shahid Sadoughi University of
   Medical Sciences; Mashhad University of Medical Sciences
RP Jazayeri, S (corresponding author), Iran Univ Med Sci, Sch Publ Hlth, Dept Nutr, Tehran, Iran.
EM Jazayeri.sh@iums.ac.ir
RI Salehi-Abargouei, Amin/C-9039-2011; jazayeri, shima/N-8951-2013;
   abolghasemi, jamileh/E-7534-2014; Mirzaei, Masoud/JVM-7958-2024; Fatemi,
   SeyedehFatemeh/JWP-2180-2024
OI Fatemi, Seyedeh Fatemeh/0000-0002-8387-308X; Mirzaei,
   Masoud/0000-0001-6455-0747
FU The authors appreciate Shahid Sadoughi University of Medical Sciences,
   Yazd, Iran, for supporting this research. They also thank Shirin
   Hasanizadeh (School of Nutrition and Food Science, Isfahan University of
   Medical Science, Isfahan, Iran), Mohammad Moham; Shahid Sadoughi
   University of Medical Sciences, Yazd, Iran; (School of Nutrition and
   Food Science, Isfahan University of Medical Science, Isfahan, Iran);
   Kermani Gaz Factory (Isfahan, Iran)
FX The authors appreciate Shahid Sadoughi University of Medical Sciences,
   Yazd, Iran, for supporting this research. They also thank Shirin
   Hasanizadeh (School of Nutrition and Food Science, Isfahan University of
   Medical Science, Isfahan, Iran), Mohammad Mohammadi (School of Medicine,
   Hormozgan University of Medical Sciences, Hormozgan, Iran) and Sahar
   Mohseni (School of Public Health, Shahid Sadoughi University of Medical
   Sciences, Yazd, Iran)for their support and contribution to this study.
   They also acknowledge with grateful appreciation the kind assistance
   provided by the Hajkhalifeh Confectionery (Yazd, Iran) and Kermani Gaz
   Factory (Isfahan, Iran).
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NR 30
TC 0
Z9 0
U1 0
U2 2
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-244X
J9 BMC PSYCHIATRY
JI BMC Psychiatry
PD SEP 27
PY 2023
VL 23
IS 1
AR 703
DI 10.1186/s12888-023-05161-5
PG 8
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Psychiatry
GA T0HG8
UT WOS:001074878500001
PM 37759180
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Skowronska, A
   Gawlik-Kotelnicka, O
   Margulska, A
   Strzelecki, D
AF Skowronska, Anna
   Gawlik-Kotelnicka, Oliwia
   Margulska, Aleksandra
   Strzelecki, Dominik
TI The Influence of Probiotic Supplementation on the Severity of Anxiety
   and Depressive Symptoms; Function and Composition of Gut Microbiota; and
   Metabolic, Inflammation, and Oxidative Stress Markers in Patients with
   Depression-A Study Protocol
SO METABOLITES
LA English
DT Article
DE microbiome; metabolism; depression; anxiety disorders
ID POSTMYOCARDIAL INFARCTION DEPRESSION; PSYCHOMETRIC PROPERTIES; CONSENSUS
   STATEMENT; DOUBLE-BLIND; FATTY-ACIDS; METAANALYSIS; COMBINATION;
   DISORDERS; HEALTH; TRIAL
AB This article aims to present the theoretical basis, methodology, and design of a clinical trial we will conduct. The study will be prospective, randomized, placebo-controlled, and double-blind. Each intervention period will last 8 weeks and the trial will be conducted on 100 patients in total, who will be randomly divided into two groups consisting of 50 patients each. We plan to investigate the impact of Lactobacillus helveticus Rosell and Bifidobacterium longum Rosell on the depressive, anxiety, and stress levels in patients with depressive disorders with possible comorbid anxiety. In addition to assessing the influence of probiotics on the clinical condition, we also plan to study the clinical and biochemical parameters of metabolic syndrome, which often coexists with depression. Both depressive and metabolic issues may have part of their etiopathology in common, e.g., inflammation, oxidative stress, and dysbiosis. This is why we will additionally investigate the parameters related to gut microbiota, inflammatory, and oxidative statuses. Thus, the primary endpoint of the study will be the change in depression score measured with the Montgomery- Asberg Depression Rating Scale. The secondary endpoints will include changes in anxiety and stress levels, as well as metabolic, inflammation, and oxidative stress parameters.
C1 [Skowronska, Anna; Gawlik-Kotelnicka, Oliwia; Strzelecki, Dominik] Med Univ Lodz, Cent Teaching Hosp, Dept Affect & Psychot Disorders, Ul Czechoslowacka 8-10, PL-92216 Lodz, Poland.
   [Margulska, Aleksandra] Med Univ Lodz, Cent Teaching Hosp, Dept Adolescent Psychiat, Ul Czechoslowacka 8-10, PL-92216 Lodz, Poland.
C3 Medical University Lodz; Medical University Lodz
RP Gawlik-Kotelnicka, O (corresponding author), Med Univ Lodz, Cent Teaching Hosp, Dept Affect & Psychot Disorders, Ul Czechoslowacka 8-10, PL-92216 Lodz, Poland.
EM oliwia.gawlik@umed.lodz.pl
RI Gawlik-Kotelnicka, Oliwia/ITU-7979-2023; Strzelecki,
   Dominik/S-9340-2016; Gawlik-Kotelnicka, Oliwia/S-9936-2016
OI Margulska, Aleksandra/0000-0003-1229-0925; Gawlik-Kotelnicka,
   Oliwia/0000-0003-1398-3117; Strzelecki, Dominik/0000-0002-8559-1078
FU Medical University of Lodz [502-03/1-155-02/502-14-386-18,
   503/1-155-02/503-11-003-20]
FX This research will be funded by the Medical University of Lodz, grant
   number 502-03/1-155-02/502-14-386-18 and 503/1-155-02/503-11-003-20.
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NR 81
TC 5
Z9 6
U1 2
U2 17
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2218-1989
J9 METABOLITES
JI Metabolites
PD FEB
PY 2023
VL 13
IS 2
AR 182
DI 10.3390/metabo13020182
PG 15
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 9K1YX
UT WOS:000940669900001
PM 36837799
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Roberts, CK
   Sindhu, KK
AF Roberts, Christian K.
   Sindhu, Kunal K.
TI Oxidative stress and metabolic syndrome
SO LIFE SCIENCES
LA English
DT Review
DE Cardiovascular disease; Hypertension; Diabetes; Free radical;
   Antioxidant; Diet; Exercise
ID C-REACTIVE PROTEIN; 3RD NATIONAL-HEALTH; SHORT-TERM DIET;
   CARDIOVASCULAR-DISEASE MORTALITY; IMPROVES ENDOTHELIAL FUNCTION;
   CIRCULATING OXIDIZED LDL; LOW-DENSITY-LIPOPROTEIN; IN-VIVO FORMATION;
   INSULIN-RESISTANCE; EXERCISE INTERVENTION
AB Metabolic syndrome is a collection of cardiometabolic risk factors that includes obesity, insulin resistance, hypertension and dyslipidemia. Although there has been significant debate regarding the criteria and concept of the syndrome, this clustering of risk factors is unequivocally linked to an increased risk of developing type 2 diabetes and cardiovascular disease. Metabolic syndrome is often characterized by oxidative stress, a condition in which an imbalance results between the production and inactivation of reactive oxygen species. Reactive oxygen species can best be described as double-edged swords; while they play an essential role in multiple physiological systems, under conditions of oxidative stress, they contribute to cellular dysfunction. Oxidative stress is thought to play a major role in the pathogenesis of a variety of human diseases, including atherosclerosis, diabetes, hypertension, aging, Alzheimer's disease, kidney disease and cancer. The purpose of this review is to discuss the role of oxidative stress in metabolic syndrome and its major clinical manifestations (namely coronary artery disease, hypertension and diabetes). It will also highlight the effects of lifestyle modification in ameliorating oxidative stress in metabolic syndrome. Discussion will be limited to human data. (C) 2009 Elsevier Inc. All rights reserved.
C1 [Roberts, Christian K.] Univ Calif Los Angeles, Dept Physiol Sci, Los Angeles, CA 90095 USA.
   [Sindhu, Kunal K.] Univ Calif Berkeley, Berkeley, CA 94720 USA.
C3 University of California System; University of California Los Angeles;
   University of California System; University of California Berkeley
RP Roberts, CK (corresponding author), Univ Calif Los Angeles, Dept Physiol Sci, Los Angeles, CA 90095 USA.
EM croberts@ucla.edu
RI Sindhu, Kunal/AAX-1948-2021
OI Sindhu, Kunal/0000-0001-9376-8307
FU American Heart Association; Western States Affiliate [0765139Y];
   American Heart Association (AHA) [0765139Y] Funding Source: American
   Heart Association (AHA)
FX Christian K. Roberts was funded by the American Heart Association,
   Western States Affiliate (#0765139Y) during the writing of this review.
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NR 146
TC 642
Z9 704
U1 0
U2 86
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0024-3205
EI 1879-0631
J9 LIFE SCI
JI Life Sci.
PD MAY 22
PY 2009
VL 84
IS 21-22
BP 705
EP 712
DI 10.1016/j.lfs.2009.02.026
PG 8
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA 448SF
UT WOS:000266281600001
PM 19281826
DA 2025-06-11
ER

PT J
AU Vanlaer, Y
   Minschart, C
   van den Keybus, K
   Myngheer, N
   Maes, T
   De Block, C
   Bochanen, N
   Van Pottelbergh, I
   Abrams, P
   Vinck, W
   Leuridan, L
   Driessens, S
   Billen, J
   Matthys, C
   Bogaerts, A
   Laenen, A
   Mathieu, C
   Benhalima, K
AF Vanlaer, Yana
   Minschart, Caro
   van den Keybus, Karolijn
   Myngheer, Nele
   Maes, Toon
   De Block, Christophe
   Bochanen, Niels
   Van Pottelbergh, Inge
   Abrams, Pascale
   Vinck, Wouter
   Leuridan, Liesbeth
   Driessens, Sabien
   Billen, Jaak
   Matthys, Christophe
   Bogaerts, Annick
   Laenen, Annouschka
   Mathieu, Chantal
   Benhalima, Katrien
TI Mental Health and Metabolic Outcomes in Early Postpartum in Women with
   Prediabetes After Gestational Diabetes: A Secondary Analysis of the
   MELINDA Trial
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Article
DE glucose intolerance; type 2 diabetes; mental health; depression;
   metabolic profile; gestational diabetes mellitus
ID PERINATAL DEPRESSION; PHYSICAL-ACTIVITY; RISK-FACTORS; INTERVENTIONS;
   DETERMINANTS; INFLAMMATION; METAANALYSIS; ASSOCIATION; PREVALENCE;
   PREGNANCY
AB Aims: To examine the association between depressive symptoms and metabolic profile in women with prior gestational diabetes mellitus (GDM) and early postpartum prediabetes, and to explore whether a mobile-based lifestyle intervention affected mental health outcomes. Methods: Secondary, exploratory analysis of a multi-centric randomized controlled trial (MELINDA), evaluating a mobile-based lifestyle intervention versus standard follow-up (control group) in women with prediabetes after GDM. The analysis included 166 participants who completed the Center for Epidemiologic Studies-Depression (CES-D) questionnaire [score of >= 16 being suggestive for (sub)clinical depression] at baseline (6-16 weeks postpartum) and one year post-randomization. Results: At one year, 26.5% of women (n = 44) reported depressive symptoms, with no significant difference between the intervention and control groups (30.5% vs. 22.6%, p = 0.293). Women with depressive symptoms (symptomatic women) were younger (30.9 +/- 4.9 vs. 32.5 +/- 3.8 years, p = 0.033) and were less often highly educated (61.4% vs. 80.3%, p = 0.028). At baseline, symptomatic women had a higher rate of metabolic syndrome (38.6% vs. 21.9%, p = 0.044), higher LDL-cholesterol [3.2 +/- 0.8 vs. 2.8 +/- 0.8 mmol/L, p = 0.009], lower quality of life (lower SF-36 scores, p < 0.050) and a higher level of anxiety based on the STAI-6 questionnaire (14.5 +/- 3.6 vs. 11.2 +/- 2.6, p < 0.001). These differences persisted at one year postpartum with worse metabolic profile, more anxiety and lower quality of life in symptomatic women. Conclusions: Depressive symptoms are common in women with prediabetes in early postpartum after GDM and are associated with a persistent worse metabolic profile, increased anxiety and lower quality of life postpartum. The mobile-based lifestyle intervention did not improve mental health.
C1 [Vanlaer, Yana; Minschart, Caro; Mathieu, Chantal; Benhalima, Katrien] Katholieke Univ Leuven, Dept Chron Dis & Metab, Clin & Expt Endocrinol, Herestraat 49, B-3000 Leuven, Belgium.
   [van den Keybus, Karolijn] Katholieke Univ Leuven, Fac Med, Herestr 49, B-3000 Leuven, Belgium.
   [Myngheer, Nele] Gen Hosp Groeninge Kortrijk, Dept Endocrinol, Campus Kennedylaan 4, B-8500 Kortrijk, Belgium.
   [Maes, Toon] Imelda Hosp, Dept Obstet & Gynecol, Schoolstraat 55, B-2820 Bonheiden, Belgium.
   [De Block, Christophe; Bochanen, Niels] Antwerp Univ Hosp, Dept Endocrinol Diabetol Metab, Wilrijkstr 10, B-2650 Edegem, Belgium.
   [Van Pottelbergh, Inge] AZORG Aalst, Dept Endocrinol, Moorselbaan 164, B-9300 Aalst, Belgium.
   [Abrams, Pascale] ZAS Hosp Sint Vincentius, Dept Endocrinol, Sint-Vincentiusstr 20, B-2018 Antwerp, Belgium.
   [Abrams, Pascale; Vinck, Wouter] ZAS Hosp Sint Augustinus, Dept Endocrinol, Oosterveldlaan 24, B-2610 Antwerp, Belgium.
   [Leuridan, Liesbeth; Driessens, Sabien] Gen Hosp Klina, Dept Endocrinol, Augustijnslei 100, B-2930 Brasschaat, Belgium.
   [Billen, Jaak] Univ Hosp Leuven, Dept Lab Med, Herestr 49, B-3000 Leuven, Belgium.
   [Matthys, Christophe] Katholieke Univ Leuven, Dept Chron Dis & Metab, Herestr 49, B-3000 Leuven, Belgium.
   [Matthys, Christophe; Mathieu, Chantal; Benhalima, Katrien] Univ Hosp Leuven, Dept Endocrinol, Herestr 49, B-3000 Leuven, Belgium.
   [Bogaerts, Annick] Katholieke Univ Leuven, Dept Dev & Regenerat, Res Unit Woman & Child, REALIFE Res Grp, Herestr 49, B-3000 Leuven, Belgium.
   [Bogaerts, Annick] Univ Plymouth, Fac Hlth, 3 Portland Mews, Plymouth PL4 8AA, Devon, England.
   [Laenen, Annouschka] Katholieke Univ Leuven, Leuven Biostat & Stat Bioinformat Ctr, Herestr 49, B-3000 Leuven, Belgium.
C3 KU Leuven; KU Leuven; Imeldaziekenhuis; University of Antwerp; KU
   Leuven; University Hospital Leuven; KU Leuven; KU Leuven; University
   Hospital Leuven; KU Leuven; University of Plymouth; KU Leuven
RP Benhalima, K (corresponding author), Katholieke Univ Leuven, Dept Chron Dis & Metab, Clin & Expt Endocrinol, Herestraat 49, B-3000 Leuven, Belgium.
EM yana.vanlaer@kuleuven.be; caro.minschart@hotmail.be;
   karolijn.vandenkeybus@student.kuleuven.be; nele.myngheer@azgroeninge.be;
   toon.maes@imelda.be; christophe.deblock@uza.be; niels.bochanen@uza.be;
   inge.van.pottelbergh@olvz-aalst.be; pascale.abrams@gza.be;
   wouter.vinck@gza.be; liesbeth.leuridan@azturnhout.be;
   sabien.driessens@klina.be; jaak.billen@uzleuven.be;
   christophe.matthys@uzleuven.be; annick.bogaerts@kuleuven.be;
   annouschka.laenen@kuleuven.be; chantal.mathieu@uzleuven.be;
   katrien.benhalima@uzleuven.be
RI Bogaerts, Annick/W-9674-2018; De Block, Christophe/JVN-4588-2024;
   Minschart, PhD, Caro/LDG-2961-2024; Polito, Angela/AAO-1596-2020
FU UZ Leuven; Novo Nordisk; Sanofi; AstraZeneca; Boehringer-Ingelheim and
   Lilly
FX The authors declare that the MELINDA study received funding from
   research fund of UZ Leuven and by an unrestricted grant of Novo Nordisk.
   The following companies provided limited research grants: Sanofi,
   AstraZeneca, Boehringer-Ingelheim and Lilly. The funder was not involved
   in the study design, collection, analysis, interpretation of data, the
   writing of this article or the decision to submit it for publication.
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   Xie HY, 2024, J AFFECT DISORDERS, V354, P160, DOI 10.1016/j.jad.2024.03.027
NR 62
TC 0
Z9 0
U1 0
U2 0
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD MAY 21
PY 2025
VL 14
IS 10
AR 3592
DI 10.3390/jcm14103592
PG 25
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 3DE4Z
UT WOS:001497524700001
PM 40429596
DA 2025-06-11
ER

PT J
AU Nikolic, G
   Tasic, I
   Zikic, O
   Tosic-Golubovic, S
   Stojanovic, N
   Simonovic, M
   Kostic, J
AF Nikolic, Gordana
   Tasic, Ivan
   Zikic, Olivera
   Tosic-Golubovic, Suzana
   Stojanovic, Nikola
   Simonovic, Maja
   Kostic, Jelena
TI The risk of metabolic syndrome in patients with arterial hypertension in
   relation to psychological and biological risk factors
SO VOJNOSANITETSKI PREGLED
LA English
DT Article
DE metabolic syndrome; hypertension; cardiovascular diseases; risk factors;
   personality; questionnaires; depression; comorbidity.
ID D PERSONALITY; NEGATIVE AFFECTIVITY; SOCIAL INHIBITION; DEPRESSION;
   AGGRESSION
AB Background/Aim. A type of personality and negative emotional reactions could be important for clustering biological risk factors for a cardiovascular disease in patients with arterial hypertension (AH). This study investigated if the patients with AH and psychological characteristics of the Distressed Type of personality with elevated anxiety/depression/aggression, have a higher risk of metabolic syndrome (MS) and explored value of the assessed parameters for MS occurrence. Methods. A total of 85 patients with AH were included in the cross-sectional observational study. Type D Scale-14 (DS-14) was used to detect Type D (Distressed) personality. The Hospital Anxiety and Depression Scale (HADS) assessed the levels of anxiety and depression and the Buss Perry Aggression Questionnaire (BPAQ) was used for the assessment of aggression. The explored biological parameters included: blood pressure, lipid status, body mass index (BMI), the occurrence of diabetes mellitus (DM) and MS. Results. Type D patients were frequently more anxious, aggressive and had more frequent MS compared to non-type D. Type D females were younger, more anxious and had a greater prevalence of DM than those with non-type D personality. A multivariate analysis revealed that in type D personality patients with AH, depression had predictive value for MS. Conclusion. The occurrence of both MS and AH was in correlation with the type D personality, anxiety and depression. Early detection/treatment of depression in patients with AH and Type D personality could decrease a risk of metabolic syndrome.
C1 [Nikolic, Gordana; Zikic, Olivera; Tosic-Golubovic, Suzana; Simonovic, Maja; Kostic, Jelena] Univ Nis, Fac Med, Dept Psychiat, Nish 18000, Serbia.
   [Tasic, Ivan] Univ Nis, Fac Med, Dept Internal Med, Nish, Serbia.
   [Stojanovic, Nikola] Univ Nis, Fac Med, Dept Physiol, Nish, Serbia.
   [Nikolic, Gordana; Zikic, Olivera; Simonovic, Maja] Clin Ctr Nis, Ctr Mental Hlth Protect, Dept Diagnost & Treatment, Nish, Serbia.
   [Tasic, Ivan] Inst Therapy & Rehabil, Niska Banja, Serbia.
   [Kostic, Jelena] Ctr Mental Hlth Protect, Dept Pediat & Adolescent Psychiat, Nish, Serbia.
C3 University of Nis; University of Nis; University of Nis
RP Nikolic, G (corresponding author), Univ Nis, Fac Med, Dept Psychiat, Nish 18000, Serbia.
EM gordanani@gmail.com
RI Stojanovic, Nikola/AFN-1152-2022; Zikic, Olivera/C-2834-2014
OI Stojanovic, Nikola/0000-0002-0124-3501; Zikic,
   Olivera/0000-0002-3014-1766
CR Altmaier E, 2013, PSYCHONEUROENDOCRINO, V38, P1299, DOI 10.1016/j.psyneuen.2012.11.014
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NR 25
TC 0
Z9 0
U1 1
U2 4
PU MILITARY MEDICAL ACAD-INI
PI BELGRADE
PA CRNOTRAVSKA 17, PO BOX 33-35, BELGRADE, 11040, SERBIA
SN 0042-8450
EI 2406-0720
J9 VOJNOSANIT PREGL
JI Vojnosanit. Pregl.
PY 2021
VL 78
IS 7
BP 716
EP 722
DI 10.2298/VSP180929130N
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA UE7OV
UT WOS:000688074000003
OA gold
DA 2025-06-11
ER

PT J
AU Zhang, JJ
   Wang, JX
   Wang, XQ
   Zhang, XY
AF Zhang, Jian-Jun
   Wang, Jingxia
   Wang, Xiao-Qian
   Zhang, Xiang-Yang
TI Gender Differences in the Prevalence and Clinical Correlates of
   Metabolic Syndrome in First-Episode and Drug-Naive Patients With Major
   Depressive Disorder
SO PSYCHOSOMATIC MEDICINE
LA English
DT Article
DE gender differences; major depressive disorder; metabolic syndrome;
   first-episode and drug-naive patients
ID HORMONE-BINDING GLOBULIN; MENTAL-HEALTH SURVEY; SEX-DIFFERENCES;
   GENERAL-POPULATION; SERUM TESTOSTERONE; SOMATIC SYMPTOMS; RISK-FACTORS;
   OBESITY; WOMEN; AGE
AB Objective Major depressive disorder (MDD) is a severe psychiatric symptom worldwide, and the coexistence of MDD with metabolic syndrome (MetS) is common in clinical practice. However, gender differences in comorbid MetS in first-episode and drug-naive (FEDN) MDD patients have not been reported. Here, we explored potential gender differences in the prevalence and clinical correlates of comorbid MetS in FEDN MDD patients.
   Methods A cross-sectional study of 1718 FEDN MDD patients was conducted. Demographic and clinical data were collected. The Hamilton Depression Scale (HAMD), Hamilton Anxiety Scale, and Positive and Negative Syndrome Scale positive subscale were used to evaluate depression, anxiety, and psychotic symptoms, respectively.
   Results The prevalence of MetS was 1.645-fold higher in female MDD patients (38.50%) than in male patients (26.53%). Patients with MetS had higher HAMD score, Hamilton Anxiety Scale score, and Positive and Negative Syndrome Scale positive subscale score than patients without MetS (p values < .001). Furthermore, suicide attempts (male: odds ratio [OR] = 1.706, p = .034; female: OR = 1.639, p = .004) and HAMD score (male: OR = 1.251, p < .001; female: OR = 1.148, p < .001) were independently associated with MetS in male and female patients, whereas age of onset was independently associated with MetS only in female patients (OR = 1.744, p = .047).
   Conclusions Our findings suggest significant gender differences in the prevalence and clinical correlates of comorbid MetS in FEDN MDD patients. Clinical variables (suicide attempts and HAMD scores) may be independently associated with MetS in MDD patients.
C1 [Zhang, Jian-Jun; Wang, Xiao-Qian] Shanxi Univ Chinese Med, Natl Int Joint Res Ctr Mol Chinese Med, Shanxi Key Lab Chinese Med Encephalopathy, Jinzhong, Peoples R China.
   [Zhang, Jian-Jun; Zhang, Xiang-Yang] Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China.
   [Wang, Jingxia] Tianjin Univ Tradit Chinese Med, Sch Nursing, Tianjin, Peoples R China.
   [Zhang, Xiang-Yang] Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China.
   [Zhang, Xiang-Yang] Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, 16 Lincui Rd, Beijing 100101, Peoples R China.
C3 Shanxi University of Chinese Medicine; Tianjin University of Traditional
   Chinese Medicine; Chinese Academy of Sciences; University of Chinese
   Academy of Sciences, CAS; Chinese Academy of Sciences; Institute of
   Psychology, CAS
RP Zhang, XY (corresponding author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, 16 Lincui Rd, Beijing 100101, Peoples R China.
EM qxzhangjianjun@126.com; wangjingxia20051010@126.com;
   wangxiaoqian2@stu.sxtcm.edu.cn; zhangxy@psych.ac.cn
RI Wang, Min/JGL-8741-2023; Wang, Xiaoqian/AAL-6743-2021; Zhang,
   Xiangyang/ABC-7380-2022
OI Zhang, Xiangyang/0000-0003-3326-382X
FU Chinese National Programs for Brain Science and Brain-like Intelligence
   Technology [2021ZD0202102]; National Natural Science Foundation of China
   [31871111]; Shanxi Provincial Key Team for Science and Technology
   Innovation in Traditional Chinese Medicine Prevention and Treatment of
   Encephalopathy and New Drug Development [2013131022]
FX This work was supported by the Chinese National Programs for Brain
   Science and Brain-like Intelligence Technology (2021ZD0202102), the
   National Natural Science Foundation of China (31871111), and Shanxi
   Provincial Key Team for Science and Technology Innovation in Traditional
   Chinese Medicine Prevention and Treatment of Encephalopathy and New Drug
   Development (2013131022).These sources had no further role in this study
   design, in the data collection and analysis, in the writing of the
   report, and in the decision to submit the paper for publication. The
   authors report no conflicts of interest.
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NR 70
TC 0
Z9 0
U1 2
U2 4
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0033-3174
EI 1534-7796
J9 PSYCHOSOM MED
JI Psychosom. Med.
PD APR
PY 2024
VL 86
IS 3
BP 202
EP 209
DI 10.1097/PSY.0000000000001293
PG 8
WC Psychiatry; Psychology; Psychology, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry; Psychology
GA ND3R2
UT WOS:001198478600004
PM 38588496
DA 2025-06-11
ER

PT J
AU Sun, FJ
   Lei, Y
   You, JJ
   Li, C
   Sun, LS
   Garza, J
   Zhang, D
   Guo, M
   Scherer, PE
   Lodge, D
   Lu, XY
AF Sun, Fengjiao
   Lei, Yun
   You, Jingjing
   Li, Chen
   Sun, Linshan
   Garza, Jacob
   Zhang, Di
   Guo, Ming
   Scherer, Phillip E.
   Lodge, Daniel
   Lu, Xin-Yun
TI Adiponectin modulates ventral tegmental area dopamine neuron activity
   and anxiety-related behavior through AdipoR1
SO MOLECULAR PSYCHIATRY
LA English
DT Article
ID INSULIN SENSITIVITY; CEREBROSPINAL-FLUID; SELECTIVE DELETION; METABOLIC
   SYNDROME; LEPTIN RECEPTOR; DEPRESSION; PROTEIN; STRESS; SUSCEPTIBILITY;
   INHIBITION
AB Adiponectin, a metabolic hormone secreted by adipocytes, can cross the blood-brain barrier to act on neurons in different brain regions, including those involved in stress-related disorders. Here we show that dopamine neurons in the ventral tegmental area (VTA) express adiponectin receptor 1 (AdipoR1). Intra-VTA infusion of adiponectin or the adiponectin mimetic AdipoRon in wild-type mice decreases basal dopamine neuron population activity and firing rate and reverses the restraint stress-induced increase in dopamine neuron activity and anxiety behavior. Adiponectin haploinsufficiency leads to increased dopamine neuron firing and anxiety behavior under basal conditions. Ablation of AdipoR1 specifically from dopamine neurons enhances neuronal and anxiogenic responses to restraint stress. The effects of intra-VTA infusion of adiponectin on neuronal activity and behavior were abolished in mice lacking AdipoR1 in dopamine neurons. These observations indicate that adiponectin can directly modulate VTA dopamine neuron activity and anxiety behavior, and that AdipoR1 is required for adiponectin-induced inhibition of dopamine neurons and anxiolytic effects. These results strengthen the idea of adiponectin as a key biological factor that links metabolic syndrome and emotional disorders.
C1 [Sun, Fengjiao; Lei, Yun; You, Jingjing; Sun, Linshan; Garza, Jacob; Zhang, Di; Lodge, Daniel; Lu, Xin-Yun] Univ Texas Hlth Sci Ctr San Antonio, Dept Pharmacol, San Antonio, TX 78229 USA.
   [Sun, Fengjiao; Li, Chen; Guo, Ming] Binzhou Med Univ Hosp, Inst Metab & Neuropsychiat Disorders, Shandong, Peoples R China.
   [Lei, Yun; Li, Chen; Lu, Xin-Yun] Augusta Univ, Med Coll Georgia, Dept Neurosci & Regenerat Med, Augusta, GA 30912 USA.
   [Scherer, Phillip E.] Univ Texas Southwestern Med Ctr Dallas, Dept Internal Med, Touchstone Diabet Ctr, Dallas, TX USA.
C3 University of Texas System; University of Texas Health Science Center at
   San Antonio; Binzhou Medical University; University System of Georgia;
   Augusta University; University of Texas System; University of Texas
   Southwestern Medical Center Dallas
RP Lu, XY (corresponding author), Univ Texas Hlth Sci Ctr San Antonio, Dept Pharmacol, San Antonio, TX 78229 USA.; Lu, XY (corresponding author), Augusta Univ, Med Coll Georgia, Dept Neurosci & Regenerat Med, Augusta, GA 30912 USA.
EM xylu@augusta.edu
RI CHEN, LI/H-2381-2014; Lodge, Daniel/K-4740-2014; Zhang,
   Di/KIK-1254-2024; Guo, Ming/JZT-6505-2024; Lei, Yun/JOZ-9869-2023
OI Guo, Ming/0000-0002-3698-5580; Lei, Yun/0000-0003-4572-6078; li,
   chen/0000-0001-5385-6249
FU NIH [MH076929, MH100583, MH096251]
FX This work was supported by NIH grants MH076929, MH100583, and MH096251
   (X-YL).
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NR 49
TC 58
Z9 62
U1 0
U2 15
PU NATURE PUBLISHING GROUP
PI LONDON
PA MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1359-4184
EI 1476-5578
J9 MOL PSYCHIATR
JI Mol. Psychiatr.
PD JAN
PY 2019
VL 24
IS 1
BP 126
EP 144
DI 10.1038/s41380-018-0102-9
PG 19
WC Biochemistry & Molecular Biology; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Neurosciences & Neurology; Psychiatry
GA HG6LF
UT WOS:000455092300009
PM 29988086
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Ringen, PA
   Faerden, A
   Antonsen, B
   Falk, RS
   Mamen, A
   Rognli, EB
   Solberg, DK
   Andreassen, OA
   Martinsen, EW
AF Ringen, Petter Andreas
   Faerden, Ann
   Antonsen, Bjornar
   Falk, Ragnhild S.
   Mamen, Asgeir
   Rognli, Eline B.
   Solberg, Dag K.
   Andreassen, Ole A.
   Martinsen, Egil W.
TI Cardiometabolic risk factors, physical activity and psychiatric status
   in patients in long-term psychiatric inpatient departments
SO NORDIC JOURNAL OF PSYCHIATRY
LA English
DT Article
DE Cardiometabolic; cardiovascular; mortality; inpatient; SMI;
   schizophrenia
ID ALL-CAUSE MORTALITY; METABOLIC SYNDROME; CARDIOVASCULAR-DISEASE;
   PSYCHOTIC DISORDERS; SEDENTARY BEHAVIOR; LIFE-STYLE; SCHIZOPHRENIA;
   METAANALYSIS; CLOZAPINE; OBESITY
AB Purpose: Cardiovascular diseases are a major cause for the markedly reduced life expectancy in people with severe mental illness (SMI). Hospital departments should provide adequate prevention of cardiometabolic risk by optimizing prevention and treatment. Characteristics of cardiometabolic risk factors in inpatients are still not well known. We aimed to describe the status of cardiometabolic risk factors in inpatients with SMI and identify associations with psychiatric status and treatment.Methods: A cross sectional descriptive study of inpatients with SMI from long term psychosis treatment wards in South Eastern Norway was performed. Comprehensive assessments of cardiometabolic risk factors, physical activity, lifestyle habits, symptoms, life satisfaction and treatment were made. Associations and potential prognostic factors were analyzed using linear and logistic regressions.Results: A total of 83 patients were included in the study, but many individual datasets were incomplete. Over half of the subjects had unhealthy eating habits. Obesity (class 1-3) was found in 44%, 23% had elevated fasting triglycerides, 26% had elevated blood pressure and 78% smoked daily. Low levels of physical activity were significantly associated with higher levels of depression (p=.007). A nominal increase in cardiometabolic risk factors was found for olanzapine and clozapine users.Conclusion: Inpatients in long term psychosis treatment wards have alarmingly high cardiometabolic risk. Level of physical activity was associated with both psychiatric and somatic health. Focus on lifestyle and somatic health should be an integral part of the treatment for hospitalized SMI patients.
C1 [Ringen, Petter Andreas; Faerden, Ann; Martinsen, Egil W.] Oslo Univ Hosp, Div Mental Hlth & Addict, POB 4956 Nydalen, N-0424 Oslo, Norway.
   [Ringen, Petter Andreas; Andreassen, Ole A.] Oslo Univ Hosp, KG Jebsen Ctr, NORMENT, Oslo, Norway.
   [Antonsen, Bjornar] Lovisenberg Diaconal Hosp, Dept Psychiat, Oslo, Norway.
   [Falk, Ragnhild S.] Oslo Univ Hosp, Oslo Ctr Biostat & Epidemiol, Oslo, Norway.
   [Mamen, Asgeir] Kristiania Univ Coll, Inst Hlth Sci, Oslo, Norway.
   [Rognli, Eline B.] Ulleval Hosp, Oslo Univ Hosp, Div Mental Hlth & Addict, Oslo, Norway.
   [Solberg, Dag K.] Diakonhjemmet Hosp, Lukas Fdn, Skjelfoss Psychiat Ctr, Oslo, Norway.
   [Solberg, Dag K.] Diakonhjemmet Hosp, Ctr Psychopharmacol, Oslo, Norway.
   [Andreassen, Ole A.; Martinsen, Egil W.] Univ Oslo, Ulleval Hosp, Oslo, Norway.
C3 University of Oslo; University of Oslo; University of Oslo; Kristiania
   University College; University of Oslo; Diakonhjemmet Hospital;
   Diakonhjemmet Hospital; University of Oslo
RP Ringen, PA (corresponding author), Oslo Univ Hosp, Div Mental Hlth & Addict, POB 4956 Nydalen, N-0424 Oslo, Norway.; Ringen, PA (corresponding author), Univ Oslo, Ulleval Hosp, NORMENT, KG Jebsen Ctr, POB 4956 Nydalen, N-0424 Oslo, Norway.
EM p.a.ringen@medisin.uio.no
RI Falk, Ragnhild/H-5613-2019; ringen, petter/C-5036-2011; Andreassen,
   Ole/AAY-7531-2020; Rognli, Eline/MDT-0030-2025; Mamen,
   Asgeir/N-9572-2019
OI Falk, Ragnhild/0000-0001-8398-3492
FU Division of Mental Health and Addiction, Oslo University Hospital;
   Skjelfoss Psychiatric Center; Research Council of Norway [223273]
FX The study received funding and resources from the Division of Mental
   Health and Addiction, Oslo University Hospital and from the Skjelfoss
   Psychiatric Center. This work was supported by the Research Council of
   Norway under Grant [223273].
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   World Health Organization, 2010, REC POP LEV PHYS ACT
NR 50
TC 39
Z9 39
U1 0
U2 8
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0803-9488
EI 1502-4725
J9 NORD J PSYCHIAT
JI Nord. J. Psychiatr.
PY 2018
VL 72
IS 4
BP 296
EP 302
DI 10.1080/08039488.2018.1449012
PG 7
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA GI5YH
UT WOS:000434446000009
PM 29523041
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Kahl, KG
   Schweiger, U
   Correll, C
   Müller, C
   Busch, ML
   Bauer, M
   Schwarz, P
AF Kahl, Kai G.
   Schweiger, Ulrich
   Correll, Christoph
   Mueller, Conrad
   Busch, Marie-Luise
   Bauer, Michael
   Schwarz, Peter
TI Depression, anxiety disorders, and metabolic syndrome in a population at
   risk for type 2 diabetes mellitus
SO BRAIN AND BEHAVIOR
LA English
DT Article
DE Anxiety disorders; major depressive disorder; metabolic syndrome; mood
   disorders; type 2 diabetes mellitus
ID PHYSICAL-ACTIVITY; MAJOR DEPRESSION; MENTAL-DISORDERS; YOUNG-ADULTS;
   SYMPTOMS; PREVALENCE; ASSOCIATION; HEALTH; COMORBIDITY; WOMEN
AB Background: Depressive symptoms have been associated with type 2 diabetes mellitus (T2DM), but less is known about anxiety disorders that can be comorbid or exist without depression. Methods: We evaluated the prevalence of psychiatric disorders in subjects consecutively examined at an outpatient clinic for diabetes prevention who were at-risk for T2DM, defined by FINDRISK scores, and compared metabolic syndrome (MetS) frequencies between subjects with and without psychiatric morbidity, entering also relevant variables for MetS into multivariate analyses. All subjects underwent an oral glucose tolerance test (OGTT). Psychiatric diagnosis was confirmed using a Structured Clinical Interview for DSM-IV. Results: Of 260 consecutively screened subjects, 150 (56.9 +/- 8.1 years old, males = 56.7%, BMI = 27.2 +/- 4.1kg/m(2)) were at-risk for T2DM and were included. MetS, present in 27% of males and 25% of females, was significantly associated with having a current anxiety disorder (P < 0.001) and lifetime major depression (P < 0.001). In logistic regression analysis, MetS was significantly associated with lifetime major depression, presence of any anxiety disorder, body weight, and physical activity. Conclusions: Our data in a high-risk group for T2DM support the association between depressive disorders and MetS, pointing to a similar role of anxiety disorders. Screening for anxiety and depression is recommended in this group at risk for T2DM.
C1 [Kahl, Kai G.; Mueller, Conrad; Busch, Marie-Luise; Bauer, Michael] Tech Univ Dresden, Dept Psychiat & Psychotherapy, Carl Gustav Carus Univ, Dresden, Germany.
   [Kahl, Kai G.] Hannover Med Sch, Dept Psychiat Social Psychiat & Psychotherapy, D-30625 Hannover, Germany.
   [Schweiger, Ulrich] Med Univ Lubeck, Sch Med, Dept Psychiat & Psychotherapy, UK SH, D-23538 Lubeck, Germany.
   [Correll, Christoph] North Shore Long Isl Jewish Hlth Syst, Zucker Hillside Hosp, Psychiat Res, Glen Oaks, NY USA.
   [Schwarz, Peter] Tech Univ Dresden, Carl Gustav Carus Univ, Dept Internal Med, Dresden, Germany.
C3 Technische Universitat Dresden; Carl Gustav Carus University Hospital;
   Hannover Medical School; University of Lubeck; Northwell Health;
   Technische Universitat Dresden; Carl Gustav Carus University Hospital
RP Kahl, KG (corresponding author), Hannover Med Sch, Dept Psychiat Social Psychiat & Psychotherapy, Carl Neuberg Str 1, D-30625 Hannover, Germany.
EM kahl.kai@mh-hannover.de
RI Schwarz, Peter/AAF-1558-2020; Correll, Christoph/D-3530-2011
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NR 53
TC 63
Z9 65
U1 0
U2 20
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN, NJ 07030 USA
SN 2162-3279
J9 BRAIN BEHAV
JI Brain Behav.
PD MAR
PY 2015
VL 5
IS 3
AR e00306
DI 10.1002/brb3.306
PG 7
WC Behavioral Sciences; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Behavioral Sciences; Neurosciences & Neurology
GA CE4BS
UT WOS:000351776400002
PM 25642391
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Dortland, AKBV
   Giltay, EJ
   van Veen, T
   Zitman, FG
   Penninx, BWJH
AF Dortland, A. K. B. van Reedt
   Giltay, E. J.
   van Veen, T.
   Zitman, F. G.
   Penninx, B. W. J. H.
TI Metabolic syndrome abnormalities are associated with severity of anxiety
   and depression and with tricyclic antidepressant use
SO ACTA PSYCHIATRICA SCANDINAVICA
LA English
DT Article
DE depression; anxiety; metabolic syndrome; abdominal obesity;
   dyslipidemia; tricyclic antidepressants
ID MAJOR DEPRESSION; YOUNG-ADULTS; RISK-FACTORS; HEALTH; SYMPTOMS;
   COMORBIDITY; INFLAMMATION; HOMEOSTASIS; MANAGEMENT; DISORDERS
AB Objective:
   The metabolic syndrome (MetSyn) predisposes to cardiovascular disease and diabetes mellitus. There might also be an association between the MetSyn and anxiety and depression, but its nature is unclear. We aimed to investigate whether diagnosis, symptom severity and antidepressant use are associated with the MetSyn.
   Method:
   We addressed the odds for the MetSyn and its components among 1217 depressed and/or anxious subjects and 629 controls, and their associations with symptom severity and antidepressant use.
   Results:
   Symptom severity was positively associated with prevalence of the MetSyn, [adjusted odds ratio (OR) 2.21 for very severe depression: 95% confidence interval (CI): 1.06-4.64, P = 0.04], which could be attributed to abdominal obesity and dyslipidemia. Tricyclic antidepressant (TCA) use also increased odds for the MetSyn (OR 2.30, 95% CI: 1.21-4.36, P = 0.01), independent of depression severity.
   Conclusion:
   The most severely depressed people and TCA users more often have the MetSyn, which is driven by abdominal adiposity and dyslipidemia.
C1 [Dortland, A. K. B. van Reedt; Giltay, E. J.; van Veen, T.; Zitman, F. G.; Penninx, B. W. J. H.] Leiden Univ, Med Ctr, Dept Psychiat, NL-2300 RC Leiden, Netherlands.
   [Penninx, B. W. J. H.] Vrije Univ Amsterdam, Med Ctr, Dept Psychiat, Amsterdam, Netherlands.
   [Penninx, B. W. J. H.] Univ Groningen, Univ Med Ctr Groningen, Dept Psychiat, NL-9713 AV Groningen, Netherlands.
C3 Leiden University; Leiden University Medical Center (LUMC); Leiden
   University - Excl LUMC; Vrije Universiteit Amsterdam; University of
   Groningen
RP Dortland, AKBV (corresponding author), Leiden Univ, Med Ctr, Dept Psychiat, B1-P,POB 9600, NL-2300 RC Leiden, Netherlands.
EM akbvanreedtdortland@lumc.nl
RI Giltay, Erik/AAL-9948-2021; Zitman, Frans/E-7705-2010; Penninx,
   Brenda/S-7627-2017
OI Giltay, Erik J./0000-0001-8874-2292
FU Netherlands Organisation for Health Research and Development
   [10-000-1002]; Netherlands Institute of Mental Health and Addiction
   (Trimbos)
FX The infrastructure for the NESDA study (http://www.nesda.nl) is funded
   through the Geestkracht program of the Netherlands Organisation for
   Health Research and Development (ZonMw, grant number 10-000-1002) and is
   supported by participating universities and mental health care
   organizations (VU University Medical Center, GGZ inGeest, Arkin, Leiden
   University Medical Center, GGZ Rivierduinen, University Medical Center
   Groningen, Lentis, GGZ Friesland, GGZ Drenthe, Scientific Institute for
   Quality of Health Care (IQ Healthcare), Netherlands Institute for Health
   Services Research (NIVEL) and Netherlands Institute of Mental Health and
   Addiction (Trimbos).
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NR 56
TC 142
Z9 146
U1 2
U2 16
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0001-690X
EI 1600-0447
J9 ACTA PSYCHIAT SCAND
JI Acta Psychiatr. Scand.
PD JUL
PY 2010
VL 122
IS 1
BP 30
EP 39
DI 10.1111/j.1600-0447.2010.01565.x
PG 10
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 604QC
UT WOS:000278292600005
PM 20456284
OA Bronze
DA 2025-06-11
ER

PT J
AU Licht, CMM
   de Geus, EJC
   Penninx, BWJH
AF Licht, Carmilla M. M.
   de Geus, Eco J. C.
   Penninx, Brenda W. J. H.
TI Dysregulation of the Autonomic Nervous System Predicts the Development
   of the Metabolic Syndrome
SO JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
LA English
DT Article
ID HEART-RATE-VARIABILITY; RESPIRATORY SINUS ARRHYTHMIA;
   DENSITY-LIPOPROTEIN CHOLESTEROL; LEFT-VENTRICULAR HYPERTROPHY; RELEASE
   NICOTINIC-ACID; BLOOD-PRESSURE; HDL-CHOLESTEROL; CARDIOVASCULAR-DISEASE;
   INSULIN-RESISTANCE; WEIGHT-LOSS
AB Context: Stress is suggested to lead to metabolic dysregulations as clustered in the metabolic syndrome. Although dysregulation of the autonomic nervous system is found to associate with the metabolic syndrome and its dysregulations, no longitudinal study has been performed to date to examine the predictive value of this stress system in the development of the metabolic syndrome.
   Objective: We examined whether autonomic nervous system functioning predicts 2-year development of metabolic abnormalities that constitute the metabolic syndrome.
   Design: Data of the baseline and 2-year follow-up assessment of a prospective cohort: the Netherlands Study of Depression and Anxiety was used.
   Setting: Participants were recruited in the general community, primary care, and specialized mental health care organizations.
   Participants: A group of 1933 participants aged 18-65 years.
   Main outcome measures: The autonomic nervous system measures included heart rate (HR), respiratory sinus arrhythmia (RSA; high RSA reflecting high parasympathetic activity), pre-ejection period (PEP; high PEP reflecting low sympathetic activity), cardiac autonomic balance (CAB), and cardiac autonomic regulation (CAR). Metabolic syndrome was based on the updated Adult Treatment Panel III criteria and included high waist circumference, serum triglycerides, blood pressure, serum glucose, and low high-density lipoprotein (HDL) cholesterol.
   Results: Baseline short PEP, low CAB, high HR, and CAR were predictors of an increase in the number of components of the metabolic syndrome during follow-up. High HR and low CAB were predictors of a 2-year decrease in HDL cholesterol, and 2-year increase in diastolic and systolic blood pressure. Short PEP and high CAR also predicted a 2-year increase in systolic blood pressure, and short PEP additionally predicted 2-year increase in diastolic blood pressure. Finally, a low baseline RSA was predictive for subsequent decreases in HDL cholesterol.
   Conclusion: Increased sympathetic activity predicts an increase in metabolic abnormalities over time. These findings suggest that a dysregulation of the autonomic nervous system is an important predictor of cardiovascular diseases and diabetes through dysregulating lipid metabolism and blood pressure over time.
C1 [Licht, Carmilla M. M.; Penninx, Brenda W. J. H.] Vrije Univ Amsterdam, Med Ctr, Dept Psychiat, NL-1081 HL Amsterdam, Netherlands.
   [Licht, Carmilla M. M.; de Geus, Eco J. C.; Penninx, Brenda W. J. H.] Vrije Univ Amsterdam, Med Ctr, Extramural Med Res Inst Hlth & Care Res, NL-1081 HL Amsterdam, Netherlands.
   [de Geus, Eco J. C.] Vrije Univ Amsterdam, Dept Biol Psychol, NL-1081 HL Amsterdam, Netherlands.
   [de Geus, Eco J. C.; Penninx, Brenda W. J. H.] Vrije Univ Amsterdam, Med Ctr, Neurosci Campus Amsterdam, NL-1081 HL Amsterdam, Netherlands.
   [Penninx, Brenda W. J. H.] Leiden Univ, Med Ctr, Dept Psychiat, Leiden, Netherlands.
   [Penninx, Brenda W. J. H.] Univ Groningen, Univ Med Ctr Groningen, Dept Psychiat, NL-9713 AV Groningen, Netherlands.
C3 Vrije Universiteit Amsterdam; Vrije Universiteit Amsterdam; Vrije
   Universiteit Amsterdam; Vrije Universiteit Amsterdam; Leiden University
   - Excl LUMC; Leiden University; Leiden University Medical Center (LUMC);
   University of Groningen
RP Licht, CMM (corresponding author), Vrije Univ Amsterdam, Med Ctr, Extramural Med Res Inst, Dept Psychiat, AJ Ernststr 1087, NL-1081 HL Amsterdam, Netherlands.
EM C.Licht@vumc.nl
RI Penninx, Brenda/S-7627-2017; de Geus, Eco/M-9318-2015
OI de Geus, Eco/0000-0001-6022-2666
FU Geestkracht program of the Netherlands Organisation for Health Research
   and Development (Zon-Mw) [10-000-1002]; NWO Grant (Vidi) [917.66.320];
   Extramural Medicine Research <SUP>+</SUP> fellowship
FX The infrastructure for the NESDA study (www.nesda.nl) is funded through
   the Geestkracht program of the Netherlands Organisation for Health
   Research and Development (Zon-Mw, Grant Number 10-000-1002) and is
   supported by participating universities and mental health care
   organizations (VU University Medical Center, Geestelijke Gezondheidszorg
   inGeest, Arkin, Leiden University Medical Center, GGZ Rivierduinen,
   University Medical Center Groningen, Lentis, GGZ Friesland, GGZ Drenthe,
   Scientific Institute for Quality of Healthcare [IQ healthcare],
   Netherlands Institute for Health Services Research [NIVEL], and
   Netherlands Institute of Mental Health and Addiction [Trimbos]). Data
   analyses were supported by NWO Grant (Vidi, 917.66.320) (to B.W.J.H.P.)
   and an Extramural Medicine Research <SUP>+</SUP> fellowship (to
   C.M.M.L.).
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NR 95
TC 110
Z9 121
U1 0
U2 32
PU ENDOCRINE SOC
PI WASHINGTON
PA 2055 L ST NW, SUITE 600, WASHINGTON, DC 20036 USA
SN 0021-972X
EI 1945-7197
J9 J CLIN ENDOCR METAB
JI J. Clin. Endocrinol. Metab.
PD JUN
PY 2013
VL 98
IS 6
BP 2484
EP 2493
DI 10.1210/jc.2012-3104
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 155GS
UT WOS:000319736500056
PM 23553857
OA Bronze
DA 2025-06-11
ER

PT J
AU Bonnet, F
   Irving, K
   Terra, JL
   Nony, P
   Berthezène, F
   Moulin, P
AF Bonnet, F
   Irving, K
   Terra, JL
   Nony, P
   Berthezène, F
   Moulin, P
TI Depressive symptoms are associated with unhealthy lifestyles in
   hypertensive patients with the metabolic syndrome
SO JOURNAL OF HYPERTENSION
LA English
DT Article
DE depression; lifestyle; metabolic syndrome; behaviour
ID CORONARY-HEART-DISEASE; PHYSICAL-ACTIVITY; HOSPITAL ANXIETY; MORTALITY;
   RISK; PREVALENCE; PREVENTION; DISORDERS; MORBIDITY; NUTRITION
AB Objective Metabolic syndrome results from a complex interaction between lifestyle and genetic factors. Among this population, adhesion to healthy recommendations is a cornerstone of cardiovascular disease prevention. We examined the association between depression and multiple unhealthy behaviours in hypertensive patients with the metabolic syndrome.
   Research design and methods Eight hundred and forty consecutive hypertensive subjects with the metabolic syndrome were studied in our secondary-care centre. Separated scores reflecting unhealthy behaviours (physical inactivity, smoking and unhealthy diet) were combined to produce a global unhealthy lifestyle score. The Hospital Anxiety and Depression scale was used to assess and quantify depression. We performed a separate analysis for each sex.
   Results The prevalence of depression (113.0 versus 7.3%, P < 0.001) was greater in women than in men. Presence of depression was significantly associated in both men and women with unhealthy diet (in particular, excessive cholesterol and total caloric intake) but also with decreased physical activity in men and with smoking habits in women. In both sexes, the global unhealthy lifestyle score, reflecting a cluster of unhealthy behaviours, was positively correlated with the depression score. In multivariate analysis, the depression score appeared in both sexes as an independent determinant of unhealthy lifestyle.
   Conclusions Among hypertensive subjects with the metabolic syndrome, depressive symptoms along a continuum of severity are independently associated with multiple unhealthy lifestyles. This suggests that even minor forms of depression may impact on adhesion to health behaviours beyond major depressive symptoms and/or psychiatric condition. (c) 2005 Lippincott Williams & Wilkins.
C1 Cardiocasc Hosp Louis Pradel, Dept Med Diabet Endocrinol, F-69394 Lyon, France.
   Cardiocasc Hosp Louis Pradel, Dept Clin Pharmacol, F-69394 Lyon, France.
   Univ Lyon, Dept Psychiat, Lyon, France.
   INSERM, U585, F-69008 Lyon, France.
C3 CHU Lyon; CHU Lyon; Institut National de la Sante et de la Recherche
   Medicale (Inserm)
RP Cardiocasc Hosp Louis Pradel, Dept Endocrinol Diabet, Unit 11, F-69394 Lyon, France.
EM fab.so.bonnet@free.fr
RI nony, patrice/F-8128-2011; Bonnet, Fabrice/G-4255-2017
OI Bonnet, Fabrice/0000-0001-9255-8228
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NR 31
TC 70
Z9 82
U1 0
U2 9
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0263-6352
EI 1473-5598
J9 J HYPERTENS
JI J. Hypertens.
PD MAR
PY 2005
VL 23
IS 3
BP 611
EP 617
DI 10.1097/01.hjh.0000160219.71350.d2
PG 7
WC Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 907SH
UT WOS:000227737700022
PM 15716704
DA 2025-06-11
ER

PT J
AU Rusowicz, J
   Serweta, A
   Idzikowski, W
   Szczepanska-Gieracha, J
AF Rusowicz, Jagoda
   Serweta, Anna
   Idzikowski, Wojciech
   Szczepanska-Gieracha, Joanna
TI Multimodal Therapeutic Approach in Women with High Risk of Metabolic
   Syndrome-A Single Group One Center Pre-Post Study
SO JOURNAL OF CLINICAL MEDICINE
LA English
DT Article
DE postmenopausal age; stress; mood; mental health; obesity; public health
ID QUALITY-OF-LIFE; DEPRESSIVE SYMPTOMS; HEALTH; DANCE; INTERVENTION;
   ADULTS
AB The study aims to determine the impact of multimodal therapeutic approach on self-perceived stress in women with high risk of Metabolic Syndrome (MetS). The study involved 43 women aged 60 years and over (mean 68.6 & PLUSMN; 6.5) participating in a Mental Health Promotion Program. Over the 3-month course of the project, all of the participants attended meetings of a support group (60-min sessions twice a week). During these meetings, they took part in general fitness training (20 min), dancing (20 min), as well as health-promoting education and psychoeducation sessions (20 min). Moreover, the participants were encouraged to modify their diet to reduce their daily fat and sugar intake. Stress levels were assessed using the Perception of Stress Questionnaire (PSQ). Mood was measured with the Geriatric Depression Scale (GDS-30). In all of the subjects, a body composition analysis was performed using a Tanita BC-545N analyzer. Abdomen and hip circumference were measured to determine the waist-hip ratio. Weight and height were measured to determine the BMI score. At the beginning of the project, the intensity of stress correlated with the level of depressive symptoms (GDS), Body Mass Index (BDI), and the amount of visceral fat. Three months of participation in the Mental Health Promotion Program resulted in a significant reduction in stress intensity (p < 0.01). At the end of the project, all of the participants expressed their willingness to continue their participation in the classes, which is very important as there is a need to conduct long-term health-promoting activities in the age group in question.</p>
C1 [Rusowicz, Jagoda; Szczepanska-Gieracha, Joanna] Wroclaw Univ Hlth & Sport Sci, Dept Physiotherapy, PL-51612 Wroclaw, Poland.
   [Serweta, Anna; Idzikowski, Wojciech] Wroclaw Univ Hlth & Sport Sci, Dept Phys Educ & Sport Sci, PL-51612 Wroclaw, Poland.
RP Rusowicz, J (corresponding author), Wroclaw Univ Hlth & Sport Sci, Dept Physiotherapy, PL-51612 Wroclaw, Poland.
EM jagodarusowicz@gmail.com; serwetanna@gmail.com;
   wojciech.idzikowski@awf.wroc.pl; joanna.szczepanska@awf.wroc.pl
RI Rusowicz, Jagoda/ABA-9562-2020; Idzikowski, Wojciech/JCO-3422-2023
OI Szczepanska-Gieracha, Joanna/0000-0001-5191-3799; Rusowicz,
   Jagoda/0000-0001-5635-9555
FU Municipality of Wroclaw
FX The study was carried out at the Foundation for Senior Citizen
   Activation SIWY DYM in Wroclaw within a Mental Health Promotion Program.
   The project received funding from the Municipality of Wroclaw
   D/WZD/2264/1/2019.
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NR 31
TC 3
Z9 3
U1 1
U2 6
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2077-0383
J9 J CLIN MED
JI J. Clin. Med.
PD NOV
PY 2021
VL 10
IS 21
AR 4915
DI 10.3390/jcm10214915
PG 12
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC General & Internal Medicine
GA WX0LT
UT WOS:000718297400001
PM 34768434
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Seipäjärvi, SM
   Tuomola, A
   Juurakko, J
   Rottensteiner, M
   Rissanen, APE
   Kurkela, JLO
   Kujala, UM
   Laukkanen, JA
   Wikgren, J
AF Seipajarvi, Santtu M.
   Tuomola, Anniina
   Juurakko, Joona
   Rottensteiner, Mirva
   Rissanen, Antti-Pekka E.
   Kurkela, Jari L. O.
   Kujala, Urho M.
   Laukkanen, Jari A.
   Wikgren, Jan
TI Measuring psychosocial stress with heart rate variability-based methods
   in different health and age groups
SO PHYSIOLOGICAL MEASUREMENT
LA English
DT Article
DE cortisol; heart rate variability; perceived stress; wellbeing; stress
ID METABOLIC SYNDROME; SHORT-TERM; PSYCHOLOGICAL STRESS; CORTISOL
   RESPONSES; YOUNGER ADULTS; ELDERLY ADULTS; RECOVERY; MEN; RISK; TIME
AB Objective. Autonomic nervous system function and thereby bodily stress and recovery reactions may be assessed by wearable devices measuring heart rate (HR) and its variability (HRV). So far, the validity of HRV-based stress assessments has been mainly studied in healthy populations. In this study, we determined how psychosocial stress affects physiological and psychological stress responses in both young (18-30 years) and middle-aged (45-64 years) healthy individuals as well as in patients with arterial hypertension and/or either prior evidence of prediabetes or type 2 diabetes. We also studied how an HRV-based stress index (Relax-Stress Intensity, RSI) relates to perceived stress (PS) and cortisol (CRT) responses during psychosocial stress. Approach. A total of 197 participants were divided into three groups: (1) healthy young (HY, N = 63), (2) healthy middle-aged (HM, N = 61) and (3) patients with cardiometabolic risk factors (Pts, N = 73, 32-65 years). The participants underwent a group version of Trier Social Stress Test (TSST-G). HR, HRV (quantified as root mean square of successive differences of R-R intervals, RMSSD), RSI, PS, and salivary CRT were measured regularly during TSST-G and a subsequent recovery period. Main results. All groups showed significant stress reactions during TSST-G as indicated by significant responses of HR, RMSSD, RSI, PS, and salivary CRT. Between-group differences were also observed in all measures. Correlation and regression analyses implied RSI being the strongest predictor of CRT response, while HR was more closely associated with PS. Significance. The HRV-based stress index mirrors responses of CRT, which is an independent marker for physiological stress, around TSST-G. Thus, the HRV-based stress index may be used to quantify physiological responses to psychosocial stress across various health and age groups.
C1 [Seipajarvi, Santtu M.; Tuomola, Anniina; Juurakko, Joona; Kurkela, Jari L. O.; Wikgren, Jan] Univ Jyvaskyla, Ctr Interdiscipinary Brain Res, Dept Psychol, Jyvaskyla, Finland.
   [Rottensteiner, Mirva; Rissanen, Antti-Pekka E.; Laukkanen, Jari A.] Cent Finland Hlth Care Dist, Jyvaskyla, Finland.
   [Rottensteiner, Mirva; Kujala, Urho M.] Univ Jyvaskyla, Fac Sport & Hlth Sci, Jyvaskyla, Finland.
   [Rissanen, Antti-Pekka E.] Univ Helsinki, Dept Sports & Exercise Med, Clinicum, Helsinki, Finland.
   [Rissanen, Antti-Pekka E.] Fdn Sports & Exercise Med, HULA Helsinki Sports & Exercise Med Clin, Helsinki, Finland.
C3 University of Jyvaskyla; Central Finland Central Hospital; University of
   Jyvaskyla; University of Helsinki
RP Seipäjärvi, SM (corresponding author), Univ Jyvaskyla, Ctr Interdiscipinary Brain Res, Dept Psychol, Jyvaskyla, Finland.
EM santtu.m.seipajarvi@jyu.fi
RI Rissanen, Antti-Pekka/AAQ-3786-2021; Kujala, Urho/AAP-2547-2020;
   Wikgren, Jan/C-9529-2013; Kurkela, Jari/MTB-2453-2025; Laukkanen,
   Jari/N-2196-2019
OI Rissanen, Antti-Pekka/0000-0003-2415-3979; Seipajarvi,
   Santtu/0000-0003-0891-2453; Kurkela, Jari/0000-0002-4437-6347; Wikgren,
   Jan/0000-0002-3403-1396; Rottensteiner, Mirva/0000-0003-1988-0952;
   Juurakko, Joona/0000-0002-1171-6739; Tuomola,
   Anniina/0000-0003-2508-9462; Kujala, Urho/0000-0002-9262-1992
FU Business Finland [2697/31/2018]; Firstbeat Technologies Ltd (Jyvaskyla,
   Finland)
FX The HealthBeat project was implemented in cooperation between the
   University of Jyvaskyla (Department of Psychology and Faculty of Sport
   and Health Sciences), Central Finland Health Care District, and
   Firstbeat Technologies Ltd. The study was funded by Business Finland
   (Grant 2697/31/2018) and Firstbeat Technologies Ltd (Jyvaskyla,
   Finland). We thank Valtteri Huttunen (Faculty of Sport and Health
   Sciences, JYU) for his notable assistance in conducting TSST-G protocol
   and Jukka Hintikka (Faculty of Sport and Health Sciences, JYU) for
   precise work in analyzing the salivary cortisol samples. We also want to
   thank Tero Myllymaki (Firstbeat Technologies Ltd) and Ilkka Korhonen
   (Firstbeat Technologies Ltd) for organizing the resources needed for
   implementing the study and Tomas Snellman (Firstbeat Technologies Ltd)
   and Janne Solanpaa (Firstbeat Technologies Ltd) for gathering and
   organizing the HRV data for the use of researchers.
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NR 57
TC 25
Z9 25
U1 6
U2 27
PU IOP Publishing Ltd
PI BRISTOL
PA TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND
SN 0967-3334
EI 1361-6579
J9 PHYSIOL MEAS
JI Physiol. Meas.
PD MAY 31
PY 2022
VL 43
IS 5
AR 055002
DI 10.1088/1361-6579/ac6b7c
PG 19
WC Biophysics; Engineering, Biomedical; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biophysics; Engineering; Physiology
GA 1N4YT
UT WOS:000800664100001
PM 35483348
OA hybrid
DA 2025-06-11
ER

PT J
AU Shea, S
   Lionis, C
   Atkinson, L
   Kite, C
   Lagojda, L
   Chaggar, SS
   Kyrou, I
   Randeva, HS
AF Shea, Sue
   Lionis, Christos
   Atkinson, Lou
   Kite, Chris
   Lagojda, Lukasz
   Chaggar, Surinderjeet S.
   Kyrou, Ioannis
   Randeva, Harpal S.
TI Support Needs and Coping Strategies in Non-Alcoholic Fatty Liver Disease
   (NAFLD): A Multidisciplinary Approach to Potential Unmet Challenges
   beyond Pharmacological Treatment
SO LIVERS
LA English
DT Review
DE non-alcoholic fatty liver disease; NAFLD; stigma; fatigue; stress;
   obesity; loneliness; isolation; compassion; coping
ID SOCIAL-ISOLATION; DEPRESSION; LONELINESS; COMPASSION; SEVERITY; FATIGUE;
   ANXIETY; ADULTS; TOUCH; RISK
AB Non-alcoholic fatty liver disease (NAFLD) is the most frequently occurring chronic liver disease, affecting approximately 25-30% of the adult general population worldwide. NAFLD reflects excess hepatic accumulation of fat in the absence of increased alcohol intake, and, due to its close association with obesity, is frequently referred to as the 'hepatic manifestation' of metabolic syndrome. Indeed, a high percentage of individuals with NAFLD present with a combination of the cardio-metabolic comorbidities that are associated with the metabolic syndrome. In addition to its well-established link with the metabolic syndrome and increased risk for cardiovascular disease, NAFLD has also been associated with certain mental health issues (e.g., depression and stress). Although this link is now being increasingly recognized, there are still unmet needs regarding the holistic management of patients with NAFLD, which could further contribute to feelings of social isolation and loneliness. The latter conditions are also increasingly reported to pose a substantial risk to overall health and quality of life. To date, there is limited research that has explored these issues among patients with NAFLD, despite existing data which indicate that perceived loneliness and isolation may pose an additional health risk. Notably, many features associated with NAFLD have been related to these concepts, such as perceived stigma, fatigue, stress, and confusion regarding this diagnosis. As such, this review aimed to assess such potential problems faced by patients with NAFLD, and to explore the possibility of unmet support needs which could lead to perceived social isolation. Moreover, the importance of a compassionate approach towards such patients is discussed, together with potential coping strategies. Future research directions and the need for a multidisciplinary approach are also highlighted.
C1 [Shea, Sue; Atkinson, Lou; Kyrou, Ioannis; Randeva, Harpal S.] Univ Warwick, Warwick Med Sch, Biomed Sci, Coventry CV4 7AL, England.
   [Shea, Sue; Kite, Chris; Kyrou, Ioannis; Randeva, Harpal S.] Univ Hosp Coventry & Warwickshire NHS Trust, Warwickshire Inst Study Diabet Endocrinol & Metab, Coventry CV2 2DX, England.
   [Lionis, Christos] Univ Crete, Sch Med, Clin Social & Family Med, Iraklion 71003, Greece.
   [Kite, Chris] Univ Wolverhampton, Fac Educ, Sch Publ Hlth Studies, Wolverhampton WV1 1LY, England.
   [Kite, Chris; Kyrou, Ioannis] Coventry Univ, Res Inst Hlth & Wellbeing, Ctr Sport Exercise & Life Sci, Coventry CV1 5FB, England.
   [Lagojda, Lukasz] Univ Hosp Coventry & Warwickshire NHS Trust, Clin Evidence Based Informat Serv CEBIS, Coventry CV2 2DX, England.
   [Chaggar, Surinderjeet S.] Forum Hlth Ctr, Sowe Valley Primary Care Network, Coventry CV2 5EP, England.
   [Kyrou, Ioannis] Aston Univ, Coll Hlth & Life Sci, Aston Med Sch, Birmingham B4 7ET, England.
   [Kyrou, Ioannis] Agr Univ Athens, Sch Food & Nutr Sci, Dept Food Sci & Human Nutr, Lab Dietet & Qual Life, Athens 11855, Greece.
C3 University of Warwick; University of Warwick; University of Crete;
   University of Wolverhampton; Coventry University; University of Warwick;
   Aston University; Agricultural University of Athens
RP Kyrou, I; Randeva, HS (corresponding author), Univ Warwick, Warwick Med Sch, Biomed Sci, Coventry CV4 7AL, England.; Kyrou, I; Randeva, HS (corresponding author), Univ Hosp Coventry & Warwickshire NHS Trust, Warwickshire Inst Study Diabet Endocrinol & Metab, Coventry CV2 2DX, England.; Kyrou, I (corresponding author), Coventry Univ, Res Inst Hlth & Wellbeing, Ctr Sport Exercise & Life Sci, Coventry CV1 5FB, England.; Kyrou, I (corresponding author), Aston Univ, Coll Hlth & Life Sci, Aston Med Sch, Birmingham B4 7ET, England.; Kyrou, I (corresponding author), Agr Univ Athens, Sch Food & Nutr Sci, Dept Food Sci & Human Nutr, Lab Dietet & Qual Life, Athens 11855, Greece.
EM kyrouj@gmail.com; harpal.randeva@uhcw.nhs.uk
RI Lionis, Christos/MBV-1499-2025; Lagojda, Lukasz/HCH-7750-2022
OI Shea, Sue/0000-0003-0745-1085; Lagojda, Lukasz/0000-0001-9793-3672;
   Kite, Chris/0000-0003-1342-274X; Lionis, Christos/0000-0002-9324-2839
FU University Hospitals Coventry; Warwickshire (UHCW) NHS Trust; General
   Charities of Coventry
FX S.S.: I.K. and H.S.R. would like to thank the University Hospitals
   Coventry and Warwickshire (UHCW) NHS Trust and the General Charities of
   Coventry for their ongoing support.
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NR 76
TC 4
Z9 4
U1 1
U2 3
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2673-4389
J9 LIVERS-BASEL
JI Livers
PD MAR
PY 2023
VL 3
IS 1
BP 1
EP 20
DI 10.3390/livers3010001
PG 20
WC Gastroenterology & Hepatology
WE Emerging Sources Citation Index (ESCI)
SC Gastroenterology & Hepatology
GA WI3Y9
UT WOS:001254214000001
OA gold, Green Published
DA 2025-06-11
ER

PT S
AU Kanbay, M
   Afsar, B
   Covic, A
AF Kanbay, Mehmet
   Afsar, Baris
   Covic, Adrian
BE Ronco, C
   Rosner, MH
TI Uric Acid as a Cardiometabolic Risk Factor: To Be or Not to Be
SO HEMODIALYSIS: NEW METHODS AND FUTURE TECHNOLOGY
SE Contributions to Nephrology
LA English
DT Article; Book Chapter
ID MUSCLE-CELL-PROLIFERATION; CHRONIC-KIDNEY-DISEASE; METABOLIC SYNDROME;
   BLOOD-PRESSURE; RENAL-DISEASE; INSULIN-RESISTANCE; ENDOTHELIAL
   DYSFUNCTION; GLOMERULAR HYPERTENSION; OXIDATIVE STRESS; HYPERURICEMIA
AB Most authorities do not consider hyperuricemia to be an important risk factor for cardiovascular or renal disease. However, emerging data suggest that elevated uric acid (UA) is actually one of the most important factors for cardiovascular disease and that it also plays a significant role in the development of renal disease and metabolic syndrome. In the current review, we will analyze the role of cardiometabolic disorders related to UA and briefly explain the pathogenetic mechanisms behind these relationships. Copyright (C) 2011 S. Karger AG, Basel
C1 [Kanbay, Mehmet] Kayseri Training & Res Hosp, Div Nephrol, Dept Med, Kayseri, Turkey.
   [Afsar, Baris] Konya Numune Hosp, Div Nephrol, Dept Med, Konya, Turkey.
   [Covic, Adrian] Gr T Popa Univ Med & Pharm, Nephrol Clin, Dialysis & Renal Transplant Ctr, CI PARHON Univ Hosp, Iasi, Romania.
C3 Kayseri Training & Research Hospital; Konya Numune Hospital; Grigore T
   Popa University of Medicine & Pharmacy; National Institute of
   Endocrinology C.I. Parhon
RP Kanbay, M (corresponding author), Alparslan Mahallesi, Umit Sokak 25-14, Kayseri, Turkey.
EM drkanbay@yahoo.com
RI 1, 1/L-6277-2019; Covic, Adrian/G-5017-2016
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NR 56
TC 20
Z9 21
U1 0
U2 2
PU KARGER
PI BASEL
PA POSTFACH, CH-4009 BASEL, SWITZERLAND
SN 0302-5144
EI 1662-2782
BN 978-3-8055-9771-5
J9 CONTRIB NEPHROL
JI Contrib.Nephrol.
PY 2011
VL 171
BP 62
EP 67
PG 6
WC Urology & Nephrology
WE Book Citation Index – Science (BKCI-S); Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA BVR88
UT WOS:000292615000009
PM 21625091
DA 2025-06-11
ER

PT J
AU Innes, KE
   Bourguignon, C
   Taylor, AG
AF Innes, KE
   Bourguignon, C
   Taylor, AG
TI Risk indices associated with the insulin resistance syndrome,
   cardiovascular disease, and possible protection with yoga: A systematic
   review
SO JOURNAL OF THE AMERICAN BOARD OF FAMILY PRACTICE
LA English
DT Review
ID CORONARY-HEART-DISEASE; BODY-FAT DISTRIBUTION; METABOLIC SYNDROME;
   CAROTID ATHEROSCLEROSIS; MILD HYPERTENSION; AEROBIC EXERCISE; OXIDATIVE
   STRESS; BAROREFLEX SENSITIVITY; BIOCHEMICAL PARAMETERS; PSYCHOLOGICAL
   STRESS
AB Objective: To conduct a systematic review of published literature regarding the effects of yoga, a promising mind-body therapy, on specific anthropometric and physiologic indices of cardiovascular disease (CVD) risk and on related clinical endpoints.
   Methods: We performed a literature search using 4 computerized English and Indian scientific databases. The search was restricted to original studies (1970 to 2004) evaluating the effects of yoga on CVD or indices of CVD risk associated with the insulin resistance syndrome (IRS). Randomized controlled trials (RCTs), nonrandomized controlled trials, uncontrolled (pre and post) clinical trials, and cross-sectional (observational) studies were included if they met specific criteria. Data were extracted regarding study design, setting, population size and characteristics, intervention type and duration, comparison group or condition, outcome assessment, data analysis and presentation, follow-up, and key results, and the quality of each study was evaluated according to specific predetermined criteria.
   Results: We identified 70 eligible studies, including 1 observational study, 26 uncontrolled clinical trials, 21 nonrandomized controlled clinical trials, and 22 RCTs. Together, the reported results of these studies indicate beneficial changes overall in several IRS-related indices of CVD risk, including glucose tolerance and insulin sensitivity, lipid profiles, anthropometric characteristics, blood pressure, oxidative stress, coagulation profiles, sympathetic activation, and cardiovagal function, as well as improvement in several clinical endpoints.
   Conclusions: Collectively, these studies suggest that yoga may reduce many IRS-related risk factors for CVD, may improve clinical outcomes, and may aid in the management of CVD and other IRS-related conditions. However, the methodologic and other limitations characterizing most of these studies preclude drawing firm conclusions. Additional high quality RCTs are needed to confirm and further elucidate the effects of standardized yoga programs on specific indices of CVD risk and related clinical endpoints.
C1 Univ Virginia Hlth Syst, Blake Ctr, Ctr Study Complementary & Alternat Therapies, Charlottesville, VA 22908 USA.
C3 University of Virginia; University of Virginia (UVA) Health System
RP Univ Virginia Hlth Syst, Blake Ctr, Ctr Study Complementary & Alternat Therapies, Suite G113,POB 800905, Charlottesville, VA 22908 USA.
EM kei6n@virginia.edu
RI Taylor, Ann/IQT-7642-2023
FU NCCIH NIH HHS [5T32 AT 00052] Funding Source: Medline
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NR 173
TC 187
Z9 225
U1 0
U2 30
PU AMER BOARD FAMILY MEDICINE
PI LEXINGTON
PA 2228 YOUNG DR, LEXINGTON, KY 40505 USA
SN 0893-8652
J9 J AM BOARD FAM PRACT
JI J. Am. Board Fam. Pract.
PD NOV-DEC
PY 2005
VL 18
IS 6
BP 491
EP 519
DI 10.3122/jabfm.18.6.491
PG 29
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 989FY
UT WOS:000233659500007
PM 16322413
OA Bronze
DA 2025-06-11
ER

PT J
AU Zeugmann, S
   Quante, A
   Heuser, I
   Schwarzer, R
   Anghelescu, I
AF Zeugmann, Sara
   Quante, Arnim
   Heuser, Isabella
   Schwarzer, Ralf
   Anghelescu, Ion
TI Inflammatory Biomarkers in 70 Depressed Inpatients With and Without the
   Metabolic Syndrome
SO JOURNAL OF CLINICAL PSYCHIATRY
LA English
DT Article
ID C-REACTIVE PROTEIN; CORONARY-HEART-DISEASE; TUMOR-NECROSIS-FACTOR;
   INSULIN-RESISTANCE; MAJOR DEPRESSION; TREATMENT RESPONSE; YOUNG-ADULTS;
   RISK-FACTORS; CYTOKINES; MARKERS
AB Objective: Chronic subclinical inflammation may be associated with the metabolic syndrome as well as with depression. We examined the impact of the metabolic syndrome on concentrations of inflammatory biomarkers in major depression.
   Method: Data for 70 inpatients with major depressive disorder (diagnosed according to ICD-10 and DSM-IV), and with or without the metabolic syndrome, were assessed 4 to 5 weeks after admission to the clinic of the Department of Psychiatry, Charite-University Medicine, Berlin, between 2005 and 2007. The metabolic syndrome was defined according to the criteria of the International Diabetes Federation (2005). Immunologic biomarkers assessed included adiponectin, resistin, serum amyloid A (SAA), C-reactive protein (CRP), fibrinogen, interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), soluble E-selectin, and CD40 ligand (CD40L). Severity of depression was measured with the 17-item Hamilton Depression Rating Scale.
   Results: After regressional correction for confounding variables and covariates, a 2-factorial analysis of variance (metabolic syndrome x time) revealed that the metabolic syndrome's presence affected adiponectin (F-43,F-1=5.56; P<.05) and IL-6 levels (F-25,F-1=6.80; P<.05) significantly. There was also a trend for effects on fibrinogen levels (F-47,F-1 = 3.66; P=.06).
   Conclusions: This is the first study to evaluate the putative additive effect of the metabolic syndrome on a panel of 9 inflammatory biomarkers in depression. Our findings support an additive effect on some (adiponectin, IL-6, and trendwise for fibrinogen) markers. Patients with the metabolic syndrome and major depression are at higher risk for more frequent and more severe cardiovascular side effects than their counterparts without the metabolic syndrome. J Clin Psychiatry 2010;71(8):1007-1016 (C) Copyright 2010 Physicians Postgraduate Press, Inc.
C1 [Zeugmann, Sara; Quante, Arnim; Heuser, Isabella; Anghelescu, Ion] Charite, Dept Psychiat, D-14050 Berlin, Germany.
   [Schwarzer, Ralf] Free Univ Berlin, Dept Hlth Psychol, D-1000 Berlin, Germany.
C3 Berlin Institute of Health; Free University of Berlin; Humboldt
   University of Berlin; Charite Universitatsmedizin Berlin; Free
   University of Berlin
RP Zeugmann, S (corresponding author), Charite, Dept Psychiat, Eschenallee 3, D-14050 Berlin, Germany.
EM sara.zeugmann@charite.de
RI Schwarzer, Ralf/C-4581-2014
OI Schwarzer, Ralf/0000-0002-0069-3826; Heuser,
   Isabella/0000-0001-7075-1158
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NR 79
TC 38
Z9 39
U1 0
U2 17
PU PHYSICIANS POSTGRADUATE PRESS
PI MEMPHIS
PA P O BOX 752870, MEMPHIS, TN 38175-2870 USA
SN 0160-6689
EI 1555-2101
J9 J CLIN PSYCHIAT
JI J. Clin. Psychiatry
PD AUG
PY 2010
VL 71
IS 8
BP 1007
EP 1016
DI 10.4088/JCP.08m04767blu
PG 10
WC Psychology, Clinical; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA 643KY
UT WOS:000281296500007
PM 20156411
DA 2025-06-11
ER

PT J
AU Kunos, G
   Osei-Hyiaman, D
   Bátkai, S
   Sharkey, KA
   Makriyannis, A
AF Kunos, George
   Osei-Hyiaman, Douglas
   Batkai, Sandor
   Sharkey, Keith A.
   Makriyannis, Alexandros
TI Should peripheral CB1 cannabinoid receptors be selectively
   targeted for therapeutic gain?
SO TRENDS IN PHARMACOLOGICAL SCIENCES
LA English
DT Review
ID ENDOCANNABINOID SYSTEM; RISK-FACTORS; ANTAGONIST SR141716; OVERWEIGHT
   PATIENTS; INSULIN-RESISTANCE; LEPTIN RESISTANCE; ADIPOSE-TISSUE;
   MESSENGER-RNA; WEIGHT-LOSS; ACTIVATION
AB Endocannabinoids, endogenous lipid ligands of cannabinoid receptors, mediate a variety of effects similar to those of marijuana. Cannabinoid CB1 receptors are highly abundant in the brain and mediate psychotropic effects, which limits their value as a potential therapeutic target. There is growing evidence for CB1 receptors in peripheral tissues that modulate a variety of functions, including pain sensitivity and obesity-related hormonal and metabolic abnormalities. In this review we propose that selective targeting of peripheral CB1 receptors has potential therapeutic value because it would help to minimize addictive, psychoactive effects in the case of CB1 agonists used as analgesics, or depression and anxiety in the case of CB1 antagonists used in the management of cardiometabolic risk factors associated with the metabolic syndrome.
C1 [Kunos, George; Osei-Hyiaman, Douglas; Batkai, Sandor] NIAAA, Lab Physiol Studies, Bethesda, MD 20892 USA.
   [Sharkey, Keith A.] Univ Calgary, Hotchkiss Brain Inst, Calgary, AB T2N 4N1, Canada.
   [Makriyannis, Alexandros] Northeastern Univ, Ctr Drug Discovery, Boston, MA 02115 USA.
C3 National Institutes of Health (NIH) - USA; NIH National Institute on
   Alcohol Abuse & Alcoholism (NIAAA); University of Calgary; Northeastern
   University
RP Kunos, G (corresponding author), NIAAA, Lab Physiol Studies, Bethesda, MD 20892 USA.
EM gkunos@mail.nih.gov
RI Sharkey, Keith/HLX-7515-2023; Bátkai, Sándor/H-7983-2014; Makriyannis,
   Alexandros/GRF-1518-2022
OI Sharkey, Keith/0000-0001-9560-1711; Osei-Hyiaman,
   Douglas/0000-0002-2725-5519
FU National Institutes of Health
FX The work of G.K., D. O-H. and S.B. is supported by intramural funds of
   the National Institutes of Health.
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NR 65
TC 120
Z9 138
U1 0
U2 6
PU ELSEVIER SCIENCE LONDON
PI LONDON
PA 84 THEOBALDS RD, LONDON WC1X 8RR, ENGLAND
SN 0165-6147
EI 1873-3735
J9 TRENDS PHARMACOL SCI
JI Trends Pharmacol. Sci.
PD JAN
PY 2009
VL 30
IS 1
BP 1
EP 7
DI 10.1016/j.tips.2008.10.001
PG 7
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 400VY
UT WOS:000262898700001
PM 19042036
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Ma, LH
   Zhuang, KP
   Ma, XY
   Chang, YW
   Zhang, T
AF Ma Lihua
   Zhuang Kaipeng
   Ma Xiyan
   Chang Yaowen
   Zhang Tao
TI Systematic review and meta-analysis of stress management intervention
   studies in patients with metabolic syndrome combined with psychological
   symptoms
SO MEDICINE
LA English
DT Article
DE intervention; meta-analysis; metabolic syndrome; psychological symptoms;
   stress management
ID INSULIN-RESISTANCE; DEPRESSION; RISK
AB Background: Metabolic syndrome is affected by many factors, including lifestyle, mood, etc. Self-management of chronic diseases has attracted significant attention from researchers. Some studies have shown that patient self-management is a very important link, which can effectively alleviate the risk of further deterioration of the disease. However, so far, there has been no report on the basis of the summary of self-management intervention programs based on emotion management, which needs further in-depth discussion by researchers.
   Methods: The Medline (PubMed), Embase (Elsevier), PsycINFO (Ovid), CBM, CNKI and Wanfang databases were searched from the establishment of the databases to June 2022, and a total of 25 studies were traced. The inclusion criteria on stress management in patients of metabolic syndrome complicated with psychological symptoms uses meta-analysis. Two investigators independently assessed the risk of bias for each study using the Cochrane risk of bias tool.16 studies and 2687participants and relevant characteristics of studies.
   Results: In the effects of intervention measures based on stress management on depression, fasting plasma glucose, 2hFPG, high-density cholesterol, self-management behavior and quality of life in patients with psychological symptoms (depression, anxiety, and schizophrenia) complicated with metabolic diseases, there are statistically significant differences between the intervention group and the control group (P < .05).
   Conclusions: Stress management intervention can effectively improve the health outcomes of patients. In all included analysis indicators, the results of the experimental group are better than those of the control group.
C1 [Ma Lihua; Ma Xiyan; Chang Yaowen] Lanzhou Univ, Hosp 1, Lanzhou 730000, Gansu Province, Peoples R China.
   [Zhuang Kaipeng; Zhang Tao] 940 Hosp Chinese Peoples Liberat Army, Lanzhou, Gansu Province, Peoples R China.
C3 Lanzhou University
RP Chang, YW (corresponding author), Lanzhou Univ, Hosp 1, Lanzhou 730000, Gansu Province, Peoples R China.
EM 444124272@qq.com; 420747742@qq.com; 444124272@qq.com; jhshuoshi@163.com;
   zhangtao940@126.com
FU Natural Science Foundation of Gansu Province [21JR1RA106]; National
   Natural Science Foundation of China [72264022]
FX This research granted from the Natural Science Foundation of Gansu
   Province (No. 21JR1RA106) and National Natural Science Foundation of
   China (No.72264022).
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NR 18
TC 1
Z9 1
U1 3
U2 8
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD OCT 20
PY 2023
VL 102
IS 42
AR e35558
DI 10.1097/MD.0000000000035558
PG 14
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA EQ9H1
UT WOS:001140501600001
PM 37861474
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Pervanidou, P
   Bastaki, D
   Chouliaras, G
   Papanikolaou, K
   Laios, E
   Kanaka-Gantenbein, C
   Chrousos, GP
AF Pervanidou, Panagiota
   Bastaki, Despoina
   Chouliaras, Giorgos
   Papanikolaou, Katerina
   Laios, Eleftheria
   Kanaka-Gantenbein, Christina
   Chrousos, George P.
TI Circadian cortisol profiles, anxiety and depressive symptomatology, and
   body mass index in a clinical population of obese children
SO STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS
LA English
DT Article
DE Anxiety; children; depression; obesity; salivary cortisol; stress
ID POSTTRAUMATIC-STRESS-DISORDER; 11-BETA-HYDROXYSTEROID DEHYDROGENASE
   TYPE-1; METABOLIC SYNDROME; MAJOR DEPRESSION; DIURNAL CORTISOL;
   ADOLESCENTS; CHILDHOOD; OVERWEIGHT; SYMPTOMS; RISK
AB Obesity is highly co-morbid with anxiety and/or depression in children, conditions that may further worsen the metabolic and cardiovascular risks for obese individuals. Dysregulation of the hypothalamic-pituitary-adrenal axis is involved in the pathophysiology of anxiety disorders, depression, and obesity, and diverse cortisol concentrations may be found in obese children, depending on their degree of psychological distress. The aim of this study was to examine cortisol profiles among obese children with or without symptoms of anxiety and depression. A group of 128 children (53% females; mean age +/- SD: 11.2 +/- 2.2 years) derived from a pediatric obesity clinic were studied. Anxiety and depressive symptomatology were assessed with appropriate instruments. Morning serum and five diurnal salivary cortisol concentrations were measured. Obese children were 3.1/2.3 times more likely to report state and trait anxiety, respectively, and 3.6 times more likely to report depressive symptoms than children of the same age group, from a contemporary Greek sample. Trait anxiety and noon salivary cortisol concentrations were significantly positively correlated (p = 0.002). Overall, salivary cortisol concentrations were increased in children with anxiety or depression symptomatology compared to obese children without any affective morbidity (p = 0.02) and to those with anxiety and depression co-morbidity (p = 0.02). In conclusion, in obese children, emotional distress expressed by symptoms of anxiety and/or depression is associated with circadian cortisol profiles reflecting a potential pathway for further morbidity. Longitudinal studies may reveal a role of cortisol in linking obesity, anxiety, and depression to the development of further psychological and physical morbidity.
C1 [Pervanidou, Panagiota] Univ Athens, Sch Med, Aghia Sophia Childrens Hosp, Dev & Behav Pediat Unit,Dept Pediat 1, GR-11527 Athens, Greece.
   [Papanikolaou, Katerina] Univ Athens, Sch Med, Aghia Sophia Childrens Hosp, Dept Child Psychiat, GR-11527 Athens, Greece.
C3 Athens Medical School; The Aghia Sophia Children's Hospital; National &
   Kapodistrian University of Athens; The Aghia Sophia Children's Hospital;
   National & Kapodistrian University of Athens; Athens Medical School
RP Pervanidou, P (corresponding author), Univ Athens, Sch Med, Aghia Sophia Childrens Hosp, Dev & Behav Pediat Unit,Dept Pediat 1, Thivon & Levadias Str, GR-11527 Athens, Greece.
EM ppervanid@med.uoa.gr
RI Kanaka-Gantenbein, Christina/AAP-3697-2020; Pervanidou,
   Panagiota/ABI-6356-2020; Chrousos, George/G-8702-2011; Papanikolaou,
   Katerina/AAB-4771-2020
OI Pervanidou, Panagiota/0000-0002-6593-6489; Laios,
   Eleftheria/0000-0001-7604-1368
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NR 53
TC 35
Z9 39
U1 0
U2 18
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1025-3890
EI 1607-8888
J9 STRESS
JI Stress
PD JAN
PY 2013
VL 16
IS 1
BP 34
EP 43
DI 10.3109/10253890.2012.689040
PG 10
WC Behavioral Sciences; Endocrinology & Metabolism; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Behavioral Sciences; Endocrinology & Metabolism; Neurosciences &
   Neurology
GA 052VA
UT WOS:000312225400005
PM 22545868
OA Bronze
DA 2025-06-11
ER

PT J
AU Xu, R
   Blanchard, BE
   McCaffrey, JM
   Woolley, S
   Corso, LML
   Duffy, VB
AF Xu, Ran
   Blanchard, Bruce E.
   McCaffrey, Jeanne M.
   Woolley, Stephen
   Corso, Lauren M. L.
   Duffy, Valerie B.
TI Food Liking-Based Diet Quality Indexes (DQI) Generated by Conceptual and
   Machine Learning Explained Variability in Cardiometabolic Risk Factors
   in Young Adults
SO NUTRIENTS
LA English
DT Article
DE diet; diet quality; cardiometabolic health; metabolic syndrome; young
   adult; principal component analysis; food preference; ridge regression
   analysis; vegetables; sweets
ID HEALTHY EATING INDEX; METABOLIC-SYNDROME; CARDIOVASCULAR-DISEASE;
   INSULIN-RESISTANCE; SODIUM-INTAKE; PATTERNS; OBESITY; ASSOCIATION;
   PREFERENCE; QUESTIONNAIRE
AB The overall pattern of a diet (diet quality) is recognized as more important to health and chronic disease risk than single foods or food groups. Indexes of diet quality can be derived theoretically from evidence-based recommendations, empirically from existing datasets, or a combination of the two. We used these methods to derive diet quality indexes (DQI), generated from a novel dietary assessment, and to evaluate relationships with cardiometabolic risk factors in young adults with (n = 106) or without (n = 106) diagnosed depression (62% female, mean age = 21). Participants completed a liking survey (proxy for usual dietary consumption). Principle component analysis of plasma (insulin, glucose, lipids) and adiposity (BMI, Waist-to-Hip ratio) measures formed a continuous cardiometabolic risk factor score (CRFS). DQIs were created: theoretically (food/beverages grouped, weighted conceptually), empirically (grouping by factor analysis, weights empirically-derived by ridge regression analysis of CRFS), and hybrid (food/beverages conceptually-grouped, weights empirically-derived). The out-of-sample CRFS predictability for the DQI was assessed by two-fold and five-fold cross validations. While moderate consistencies between theoretically- and empirically-generated weights existed, the hybrid outperformed theoretical and empirical DQIs in cross validations (five-fold showed DQI explained 2.6% theoretical, 2.7% empirical, and 6.5% hybrid of CRFS variance). These pilot data support a liking survey that can generate reliable/valid DQIs that are significantly associated with cardiometabolic risk factors, especially theoretically- plus empirically-derived DQI.
C1 [Xu, Ran; Blanchard, Bruce E.; McCaffrey, Jeanne M.; Corso, Lauren M. L.; Duffy, Valerie B.] Univ Connecticut, Dept Allied Hlth Sci, 358 Mansfield Rd, Storrs, CT 06269 USA.
   [Woolley, Stephen] Hartford Hosp, Inst Living, 200 Retreat Ave, Hartford, CT 06106 USA.
C3 University of Connecticut; Hartford Hospital
RP Duffy, VB (corresponding author), Univ Connecticut, Dept Allied Hlth Sci, 358 Mansfield Rd, Storrs, CT 06269 USA.
EM ran.2.xu@uconn.edu; bruce.blanchard@uconn.edu;
   jeanne.mccaffery@uconn.edu; stevewo2003@yahoo.com;
   lauren.lamberti@uconn.edu; valerie.duffy@uconn.edu
RI Xu, Ran/M-4535-2016; Duffy, Valerie/HSC-6609-2023
OI Duffy, Valerie/0000-0002-4226-064X
FU United States Department of Agriculture National Institute of Food and
   Agriculture, Hatch project [1001056]; NIFA [689240, 1001056] Funding
   Source: Federal RePORTER
FX This research was funded by the United States Department of Agriculture
   National Institute of Food and Agriculture, Hatch project 1001056.
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NR 90
TC 11
Z9 13
U1 1
U2 16
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD APR
PY 2020
VL 12
IS 4
AR 882
DI 10.3390/nu12040882
PG 21
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nutrition & Dietetics
GA LL8VE
UT WOS:000531831300002
PM 32218114
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Kim, KH
   Cho, YY
   Shin, DW
   Lee, JH
   Ko, YJ
   Park, SM
AF Kim, Kyae Hyung
   Cho, Young Youn
   Shin, Dong Wook
   Lee, Ju Hyun
   Ko, Young-Jin
   Park, Sang Min
TI Comparison of physical and mental health status between cancer survivors
   and the general population: a Korean population-based survey (KNHANES
   II-IV)
SO SUPPORTIVE CARE IN CANCER
LA English
DT Article
DE Neoplasms; Survivors; Metabolic syndrome; Lifestyle; Health behavior;
   Depression; Suicidal thought
ID QUALITY-OF-LIFE; LONG-TERM RISK; SUICIDAL THOUGHTS; METABOLIC SYNDROME;
   CHILDHOOD-CANCER; NATIONAL-HEALTH; ADULT SURVIVORS; BREAST-CANCER;
   DEPRESSION; PREVALENCE
AB To compare the physical and mental health status of the general population with that of cancer survivors in South Korea.
   We analyzed 19,035 subjects (age a parts per thousand yen40 years), who participated in the 2001-2009 Korea National Health and Nutrition Examination Survey II-IV. We compared metabolic syndrome components, health behaviors, and mental health outcomes between cancer survivors and non-cancer controls.
   Cancer survivors accounted for 1.68 % (n = 316) of total population. Cancer survivors did not show low occurrence of hypertension and diabetes compared to the control group. Both cancer survivors and the general population had high risks of physical inactivity (75.4 % and 75.5 %, respectively) and inadequate sleep (52.5 % and 60.7 %, respectively). In the unadjusted model, depression was more common in cancer survivors (odds ratio [OR], 1.61; 95 % CI, 1.22-2.74), so was suicidal ideation (OR, 1.51; 95 % CI, 0.16-1.96) than non-cancer controls. After adjustment for attributable socioeconomic factors, the elevated adjusted odds ratios (aORs) among cancer survivors were reduced by 23 % in depression and 45 % in suicidal thought. Cancer survivors at < 5 years from diagnosis showed a high occurrence of depression (aOR, 1.77; 95 % CI, 1.09-2.85) while the magnitude of aOR decreases after a parts per thousand yen5 years from cancer diagnosis (aOR, 1.38; 95 % confidence interval, 0.97-1.98, respectively).
   The physical and mental health of South Korean cancer survivors was not optimal. Their control rates of modifiable risk factors were similar or even lower than those for the non-cancer groups. Depression was highly prevalent in cancer survivors which can be ascribed, at least in part, to socioeconomic environment. A better-targeted intervention to improve the health of this population may be needed.
C1 [Park, Sang Min] Seoul Natl Univ, Coll Med, Dept Family Med, Seoul 110744, South Korea.
   [Park, Sang Min] Seoul Natl Univ, Coll Med, Dept Biomed Sci, Seoul 110744, South Korea.
   [Kim, Kyae Hyung; Shin, Dong Wook; Lee, Ju Hyun; Ko, Young-Jin] Seoul Natl Univ Hosp, Dept Family Med, Seoul 110744, South Korea.
   [Cho, Young Youn] Seoul Natl Univ Hosp, Dept Internal Med, Seoul 110744, South Korea.
C3 Seoul National University (SNU); Seoul National University (SNU); Seoul
   National University (SNU); Seoul National University Hospital; Seoul
   National University (SNU); Seoul National University Hospital
RP Park, SM (corresponding author), Seoul Natl Univ, Coll Med, Dept Family Med, 28 Yunkeon Dong, Seoul 110744, South Korea.
EM smpark.snuh@gmail.com
RI Kim, Sang/J-5399-2012; Shin, Dongwook/J-6721-2016; Park,
   Sang/V-9194-2019
OI Cho, Young Youn/0000-0002-9384-5357; Kim, Kyae Hyung/0000-0001-9954-6422
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NR 55
TC 21
Z9 21
U1 0
U2 8
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0941-4355
EI 1433-7339
J9 SUPPORT CARE CANCER
JI Support. Care Cancer
PD DEC
PY 2013
VL 21
IS 12
BP 3471
EP 3481
DI 10.1007/s00520-013-1939-8
PG 11
WC Oncology; Health Care Sciences & Services; Rehabilitation
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Oncology; Health Care Sciences & Services; Rehabilitation
GA 250YE
UT WOS:000326892100029
PM 23955095
DA 2025-06-11
ER

PT J
AU Ortega, Y
   Aragones, E
   Piñol, JL
   Basora, J
   Araujo, A
   Cabré, JJ
AF Ortega, Yolanda
   Aragones, Enric
   Pinol, Josep L.
   Basora, Josep
   Araujo, Alvaro
   Cabre, Juan J.
TI Impact of depression and/or anxiety on the presentation of
   cardiovascular events in a cohort with metabolic syndrome. StreX
   project: Five years of follow-up
SO PRIMARY CARE DIABETES
LA English
DT Article
DE Mood disorders; Metabolic syndrome; Cardiovascular diseases
ID INSULIN-RESISTANCE; PRIMARY-CARE; LONG-TERM; COMORBIDITY; MORTALITY;
   OUTCOMES
AB Objectives: To determine the role of anxiety and depression on the incidence of cardiovascular events (CVE) in a Catalonian population with metabolic syndrome (MetS) over a five-year follow-up according to the number/type of MetS criteria.
   Methods: Prospective study to determine the incidence of CVE according to the presence of anxiety and depression disorders among individuals with different combinations of clinical traits of the MetS. Setting: Primary Care, Catalonia (Spain). Subjects: 35-75 years old fulfilling MetS criteria without CVE at the initiation of follow-up (2009). We studied 16 MetS phenotypes [NCEP-ATPIII criteria] based on the presence of depression/anxiety. The primary endpoint was the incidence of CVE at five years.
   Results: We analyzed 401,743 people with MetS (17.2% of the population); 8.7% had depression, 16.0% anxiety and 3.8% both. 14.5% consumed antidepressants and 20.8% tranquilizers. At the 5-year follow-up, the incidence of CVE was 5.5%, being 6.4% in men and 4.4% in women. On comparing individuals with and without depression the incidence of CVE was 6.7% vs. 5.3%, respectively (p <0.01), being 5.5% in both groups in relation to anxiety.
   Conclusion: Depression and anxiety play a role in the poor prognosis of patients with MetS. In Catalonia, the two predominant MetS phenotypes do not include obesity as a criterion. (C) 2017 Primary Care Diabetes Europe. Published by Elsevier Ltd. All rights reserved.
C1 [Ortega, Yolanda; Araujo, Alvaro] Catalan Hlth Inst, Basic Hlth Ctr Salou, Tarragona, Spain.
   [Ortega, Yolanda; Aragones, Enric; Pinol, Josep L.; Basora, Josep; Cabre, Juan J.] Catalan Hlth Inst, IDIAP Jordi Gol, Tarragona, Spain.
   [Aragones, Enric] Catalan Hlth Inst, Primary Hlth Ctr Constanti, Tarragona, Spain.
   [Pinol, Josep L.] Catalan Hlth Inst, Primary Hlth Ctr Ampolla, Tarragona, Spain.
   [Cabre, Juan J.] Catalan Hlth Inst, Basic Hlth Ctr St Pere Ctr, Tarragona, Spain.
   [Pinol, Josep L.; Basora, Josep; Cabre, Juan J.] Rovira & Virgili Univ, IISPV Pere Virgili, Reus, Spain.
C3 Universitat Rovira i Virgili
RP Cabré, JJ (corresponding author), Cami Riudoms 53-55, Tarragona 43202, Spain.
EM jcabre.tgn.ics@gencat.cat
RI Araujo, Alvaro/AAA-2298-2019; Cabre, Juan/AAN-5059-2020; Aragones,
   Enric/N-5209-2017
OI Cabre Vila, Juan Jose/0000-0003-1082-6861; Aragones,
   Enric/0000-0002-5245-4667
FU SIDIAP; IDIAP Jordi Gol. Project; CAMFiC (Catalan Society of Family and
   Community Medicine); SEMFYC (Spanish Society of Family and Community
   Medicine)
FX This study was performed with a grant from SIDIAP: under SIDIAP-2013,
   IDIAP Jordi Gol. Project: "Evaluation of cardiovascular risk associated
   with different clinical phenotypes of the metabolic syndrome and the
   additional risk associated with the presence of depression/anxiety."
   Researcher: Enric Aragones. Mental Health Research group/Primary Care.
   Research Support Unity of Tarragona. First prize of Research Grants
   CAMFiC 2009 (Catalan Society of Family and Community Medicine).Grant
   "Isabel Fernandez", for Doctoral Thesis, 2010. SEMFYC (Spanish Society
   of Family and Community Medicine).
CR [Anonymous], 2004, WHITEHALL BOOKLET WO
   [Anonymous], TENSION SIN ANGUSTIA
   Aragonès E, 2004, INT J PSYCHIAT MED, V34, P331, DOI 10.2190/N835-FDYX-2E2E-V8XM
   Aragonès E, 2007, BMC PUBLIC HEALTH, V7, DOI 10.1186/1471-2458-7-253
   Aragonès E, 2014, J AFFECT DISORDERS, V166, P36, DOI 10.1016/j.jad.2014.05.003
   Butnoriene J, 2015, INT J CARDIOL, V190, P360, DOI 10.1016/j.ijcard.2015.04.122
   Bystritsky A, 2014, ENDOCRIN METAB CLIN, V43, P269, DOI 10.1016/j.ecl.2013.10.001
   Cabré JJ, 2008, BMC PUBLIC HEALTH, V8, DOI 10.1186/1471-2458-8-251
   Carroll D, 2009, BIOL PSYCHIAT, V66, P91, DOI 10.1016/j.biopsych.2009.02.020
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NR 25
TC 7
Z9 8
U1 0
U2 2
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1751-9918
EI 1878-0210
J9 PRIM CARE DIABETES
JI Prim. Care Diabetes
PD APR
PY 2018
VL 12
IS 2
BP 163
EP 171
DI 10.1016/j.pcd.2017.09.002
PG 9
WC Endocrinology & Metabolism; Primary Health Care
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; General & Internal Medicine
GA GA7AQ
UT WOS:000428487400009
PM 28988658
DA 2025-06-11
ER

PT J
AU Gentile, C
   Ditto, B
   Deschamps, A
   D'Antono, B
AF Gentile, Christina
   Ditto, Blaine
   Deschamps, Alain
   D'Antono, Bianca
TI Parasympathetic Response Patterns are Associated with Metabolic Syndrome
   Among Older Women but Not Men
SO ANNALS OF BEHAVIORAL MEDICINE
LA English
DT Article
DE Sex differences; Metabolic syndrome; Stress; Autonomic; Heart-rate
   variability
ID HEART-RATE-VARIABILITY; ACUTE PSYCHOLOGICAL STRESS; CARDIOVASCULAR
   REACTIVITY; SERUM-LIPIDS; ATHEROSCLEROSIS RISK; AUTONOMIC IMBALANCE;
   ANGER SUPPRESSION; PHYSICAL-ACTIVITY; CENTRAL ADIPOSITY; SEX-DIFFERENCES
AB Background Little is known about the role of physiological stress responses in metabolic syndrome (MetS).
   Purpose To examine whether patterns of autonomic response to psychological stress are associated with MetS and whether this association is moderated by sex
   Methods 1121 men and women (M-age = 65.3 6.77 years) with and without coronary artery disease (CAD) underwent an anger recall stressor task. Heart rate and heart-rate variability (HRV; HF, LF/HF) were assessed. Clusters of participants showing similar patterns of response across baseline, stress, and recovery periods were created using ACECLUS and FASTCLUS in SAS. Logistic regressions included clusters and interaction between clusters and sex as independent variables, controlling for relevant covariates. ANCOVAs were conducted in secondary analyses utilizing a continuous composite representation of MetS.
   Results Men and women showing greater tonic and phasic HR elevations were more likely to meet MetS criteria (OR = 1.45, [95% CI = 1.02-2.07], p = .037). HF-HRV cluster interacted significantly with sex (p < .001) to predict MetS. In women, those with significant parasympathetic withdrawal to stress and poor recovery were more likely to have MetS than women with a more moderate response (OR = 2.56, [95% CI = 1.23-5.41], p = .013). Women who displayed stress-related parasympathetic activation were also at greater risk of MetS (OR = 2.30, [95% CI = 1.30-4.07], p = .004). Results using a continuous measure of MetS were generally consistent with these findings.
   Conclusion Among older participants with CAD or other noncardiovascular disease, hyperreactivity to stress was associated with greater prevalence of MetS, particularly in women. Consistent with emerging literature, women who showed blunting or activation of parasympathetic responses to stress were similarly at greater risk.
   Older women exhibiting non-normative parasympathetic stress responses are more likely to have metabolic syndrome than women with more moderate responses to psychological stress.
C1 [Gentile, Christina; D'Antono, Bianca] Montreal Heart Inst, Res Ctr, 5000 Belanger St, Montreal, PQ H1T 1C8, Canada.
   [Gentile, Christina; D'Antono, Bianca] Univ Montreal, Psychol Dept, Montreal, PQ, Canada.
   [Ditto, Blaine] McGill Univ, Dept Psychol, Montreal, PQ, Canada.
   [Deschamps, Alain] Montreal Heart Inst, Dept Anesthesiol, Montreal, PQ, Canada.
C3 Universite de Montreal; Universite de Montreal; McGill University;
   Universite de Montreal
RP D'Antono, B (corresponding author), Montreal Heart Inst, Res Ctr, 5000 Belanger St, Montreal, PQ H1T 1C8, Canada.; D'Antono, B (corresponding author), Univ Montreal, Psychol Dept, Montreal, PQ, Canada.
EM bianca.d.antono@umontreal.ca
FU Canadian Institutes of Health Research [111015]; Canadian Institutes of
   Health Research (CIHR) [111015]; Doctoral Training Award by the the
   Fonds de la recherche en sante du Quebec (FRSQ); Frederick Banting and
   Charles Best Canada Graduate Scholarship by the Canadian Institutes of
   Health Research [220905]
FX Many thanks to Crina Solomon and students of the Heart and Mind Research
   Unit in Behavioral and Complementary Medicine for their contributions to
   testing and data preparation required for this manuscript. Special
   thanks to Marieve Cossette, biostatistician at the Montreal Health
   Innovations Coordinating Center. Thank you to the Canadian Institutes of
   Health Research for their generous support of this study, MOP #111015.
   Finally, thanks to the personnel and participants of the Andre and
   France Desmarais Hospital Cohort of the Montreal Heart Institute who
   made this research possible. This research was supported by grants
   awarded to Bianca D'Antono by the Canadian Institutes of Health Research
   (CIHR; MOP #111015). Christina Gentile was supported by the Doctoral
   Training Award issued by the the Fonds de la recherche en sante du
   Quebec (FRSQ) and the Frederick Banting and Charles Best Canada Graduate
   Scholarship issued by the Canadian Institutes of Health Research
   (#220905). The funding sources had no involvement in this study.
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NR 90
TC 9
Z9 9
U1 1
U2 5
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0883-6612
EI 1532-4796
J9 ANN BEHAV MED
JI Ann. Behav. Med.
PD JUN
PY 2019
VL 53
IS 6
BP 515
EP 526
DI 10.1093/abm/kay063
PG 12
WC Psychology, Multidisciplinary
WE Social Science Citation Index (SSCI)
SC Psychology
GA IQ5OV
UT WOS:000480803000002
PM 30113625
OA hybrid, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Wynchank, D
   Bijlenga, D
   Lamers, F
   Kooij, JJS
   Bron, TI
   Beekman, ATF
   Penninx, BWJH
AF Wynchank, Dora
   Bijlenga, Denise
   Lamers, Femke
   Kooij, J. J. Sandra
   Bron, Tannetje I.
   Beekman, Aartjan T. F.
   Penninx, Brenda W. J. H.
TI The Association Between Metabolic Syndrome, Obesity-Related Outcomes,
   and ADHD in Adults With Comorbid Affective Disorders
SO JOURNAL OF ATTENTION DISORDERS
LA English
DT Article
DE ADHD; metabolic syndrome; depression; anxiety
ID ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; DEFICIT HYPERACTIVITY
   DISORDER; BODY-MASS INDEX; BLOOD-PRESSURE; EATING BEHAVIORS; DEPRESSION;
   SYMPTOMS; ANXIETY; CHILDREN; HEALTH
AB Objective: ADHD may predispose to obesity, a metabolic syndrome component. Affective disorders are also associated with MetSyn and ADHD. This study examined whether ADHD confers any added risk of MetSyn and obesity-related associations in a large sample with varying stages of affective disorders. Method: Participants included 2,303 adults from the Netherlands Study of Depression and Anxiety. Three groups were compared (controls, those with depressive/anxiety disorders without ADHD; and those with depressive/anxiety disorders and ADHD) for presence of MetSyn risk factors, body mass index, and waist-hip ratio. ADHD symptoms were identified by using a T-score > 65 (Conners Adult ADHD Rating Scale). Results: Multivariable analyses were additionally adjusted for sociodemographic, lifestyle, health factors, and affective disorders. Analyses showed no significant association between MetSyn, obesity-related variables, and comorbid ADHD. High Inattention and Hyperactivity/Impulsivity symptoms were not associated with MetSyn. Conclusion: This study did not confirm that MetSyn and obesity-related parameters are increased in comorbid ADHD.
C1 [Wynchank, Dora; Bijlenga, Denise; Kooij, J. J. Sandra; Bron, Tannetje I.] PsyQ Expertise Ctr Adult ADHD, Carel Reinierszkade 197, NL-2593 HR The Hague, Netherlands.
   [Lamers, Femke; Beekman, Aartjan T. F.; Penninx, Brenda W. J. H.] Vrije Univ Amsterdam, Med Ctr, Amsterdam, Netherlands.
C3 Vrije Universiteit Amsterdam
RP Wynchank, D (corresponding author), PsyQ Expertise Ctr Adult ADHD, Carel Reinierszkade 197, NL-2593 HR The Hague, Netherlands.
EM d.wynchank@psyq.nl
RI Beekman, Aartjan T./LUZ-6919-2024; Kooij, J.J./AAK-3304-2021; Lamers,
   Femke/G-5161-2012; Penninx, Brenda/S-7627-2017
OI Beekman, Aartjan TF/0000-0003-2382-1410; Lamers,
   Femke/0000-0003-4344-5766; Kooij, J.J. Sandra/0000-0002-8644-6323
FU Netherlands Foundation for Mental Health [2013-6777]; Geestkracht
   Program of the Netherlands Organization for Health Research and
   Development (Zon-Mw) [10-000-1002]; VU University Medical Center; GGZ in
   Geest; Arkin; Leiden University Medical Center; GGZ Rivierduinen;
   University Medical Center Groningen; Lentis; GGZ Friesland; GGZ Drenthe;
   Scientific Institute for Quality of Healthcare (IQ healthcare);
   Netherlands Institute for Health Services Research (NIVEL); Netherlands
   Institute of Mental Health and Addiction (Trimbos Institute)
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: This study
   is funded by the Netherlands Foundation for Mental Health (grant number
   2013-6777). The infrastructure for the NESDA study (www.nesda.nl) is
   funded through the Geestkracht Program of the Netherlands Organization
   for Health Research and Development (Zon-Mw, grant number 10-000-1002).
   This organization had no further role in study design, collection,
   analysis and interpretation of data, writing of the report, and in the
   decision to submit the paper for publication. NESDA is supported by
   participating universities and mental health care organizations (VU
   University Medical Center, GGZ in Geest, Arkin, Leiden University
   Medical Center, GGZ Rivierduinen, University Medical Center Groningen,
   Lentis, GGZ Friesland, GGZ Drenthe, Scientific Institute for Quality of
   Healthcare (IQ healthcare), Netherlands Institute for Health Services
   Research (NIVEL) and Netherlands Institute of Mental Health and
   Addiction (Trimbos Institute).
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NR 86
TC 14
Z9 15
U1 0
U2 14
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1087-0547
EI 1557-1246
J9 J ATTEN DISORD
JI J. Atten. Disord.
PD MAR
PY 2018
VL 22
IS 5
SI SI
BP 460
EP 471
DI 10.1177/1087054716659137
PG 12
WC Psychology, Developmental; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA FV7HZ
UT WOS:000424755600006
PM 27422611
DA 2025-06-11
ER

PT J
AU Barale, C
   Russo, I
AF Barale, Cristina
   Russo, Isabella
TI Influence of Cardiometabolic Risk Factors on Platelet Function
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE adipose tissue; adipokines; hemostasis; insulin resistance; metabolic
   syndrome; nitric oxide; oxidative stress; platelets; thrombosis
ID ENDOTHELIAL GROWTH-FACTOR; SOLUBLE CD40 LIGAND; DISULFIDE BOND
   FORMATION; LOW-DENSITY-LIPOPROTEIN; HUMAN REGULAR INSULIN; METABOLIC
   SYNDROME; NITRIC-OXIDE; CYCLIC-NUCLEOTIDES; CARDIOVASCULAR-DISEASE;
   DIABETES-MELLITUS
AB Platelets are key players in the thrombotic processes. The alterations of platelet function due to the occurrence of metabolic disorders contribute to an increased trend to thrombus formation and arterial occlusion, thus playing a major role in the increased risk of atherothrombotic events in patients with cardiometabolic risk factors. Several lines of evidence strongly correlate metabolic disorders such as obesity, a classical condition of insulin resistance, dyslipidemia, and impaired glucose homeostasis with cardiovascular diseases. The presence of these clinical features together with hypertension and disturbed microhemorrheology are responsible for the prothrombotic tendency due, at least partially, to platelet hyperaggregability and hyperactivation. A number of clinical platelet markers are elevated in obese and type 2 diabetes (T2DM) patients, including the mean platelet volume, circulating levels of platelet microparticles, oxidation products, platelet-derived soluble P-selectin and CD40L, thus contributing to an intersection between obesity, inflammation, and thrombosis. In subjects with insulin resistance and T2DM some defects depend on a reduced sensitivity to mediators-such as nitric oxide and prostacyclin-playing a physiological role in the control of platelet aggregability. Furthermore, other alterations occur only in relation to hyperglycemia. In this review, the main cardiometabolic risk factors, all components of metabolic syndrome involved in the prothrombotic tendency, will be taken into account considering some of the mechanisms involved in the alterations of platelet function resulting in platelet hyperactivation.
C1 [Barale, Cristina; Russo, Isabella] Turin Univ, Dept Clin & Biol Sci, I-10043 Turin, Italy.
C3 University of Turin
RP Russo, I (corresponding author), Turin Univ, Dept Clin & Biol Sci, I-10043 Turin, Italy.
EM cristina.barale@unito.it; isabella.russo@unito.it
RI Russo, Isabella/AAC-5779-2020; Barale, Cristina/AAU-9714-2021
OI Russo, Isabella/0000-0002-2921-1763; Barale,
   Cristina/0000-0003-3201-5883
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NR 228
TC 73
Z9 74
U1 0
U2 6
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD JAN 2
PY 2020
VL 21
IS 2
AR 623
DI 10.3390/ijms21020623
PG 27
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA KO2KZ
UT WOS:000515380000253
PM 31963572
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Al-Hakeim, HK
   Hadi, HH
   Jawad, GA
   Maes, M
AF Al-Hakeim, Hussein Kadhem
   Hadi, Hadi Hasan
   Jawad, Ghoufran Akeel
   Maes, Michael
TI Intersections between Copper, β-Arrestin-1, Calcium, FBXW7, CD17,
   Insulin Resistance and Atherogenicity Mediate Depression and Anxiety Due
   to Type 2 Diabetes Mellitus: A Nomothetic Network Approach
SO JOURNAL OF PERSONALIZED MEDICINE
LA English
DT Article
DE depression; mood disorders; inflammation; oxidative stress; nitrosative
   stress; neuro-immune; antioxidants; psychoneuroimmunology
ID NITROSATIVE STRESS PATHWAYS; METABOLIC SYNDROME; MAJOR DEPRESSION;
   OXIDATIVE STRESS; ACID SPHINGOMYELINASE; BIPOLAR DISORDER; MOOD
   DISORDERS; BETA-ARRESTINS; FETUIN-A; PLASMA
AB Type 2 diabetes mellitus (T2DM) is frequently accompanied by affective disorders with a prevalence of comorbid depression of around 25%. Nevertheless, the biomarkers of affective symptoms including depression and anxiety due to T2DM are not well established. The present study delineated the effects of serum levels of copper, zinc, beta-arrestin-1, FBXW7, lactosylceramide (LacCer), serotonin, calcium, magnesium on severity of depression and anxiety in 58 men with T2DM and 30 healthy male controls beyond the effects of insulin resistance (IR) and atherogenicity. Severity of affective symptoms was assessed using the Hamilton Depression and Anxiety rating scales. We found that 61.7% of the variance in affective symptoms was explained by the multivariate regression on copper, beta-arrestin-1, calcium, and IR coupled with atherogenicity. Copper and LacCer (positive) and calcium and BXW7 (inverse) had significant specific indirect effects on affective symptoms, which were mediated by IR and atherogenicity. Copper, beta-arrestin-1, and calcium were associated with affective symptoms above and beyond the effects of IR and atherogenicity. T2DM and affective symptoms share common pathways, namely increased atherogenicity, IR, copper, and beta-arrestin-1, and lowered calcium, whereas copper, beta-arrestin-1, calcium, LacCer, and FBXW7 may modulate depression and anxiety symptoms by affecting T2DM.
C1 [Al-Hakeim, Hussein Kadhem; Hadi, Hadi Hasan; Jawad, Ghoufran Akeel] Univ Kufa, Coll Sci, Dept Chem, Najaf 54001, Iraq.
   [Maes, Michael] Med Univ Plovdiv, Dept Psychiat, Plovdiv 4002, Bulgaria.
   [Maes, Michael] Chulalongkorn Univ, Fac Med, Dept Psychiat, Bangkok 10330, Thailand.
   [Maes, Michael] Deakin Univ, IMPACT Strateg Res Ctr, Sch Med, POB 281, Geelong, Vic 3220, Australia.
C3 University of Kufa; Medical University Plovdiv; Chulalongkorn
   University; Deakin University
RP Maes, M (corresponding author), Med Univ Plovdiv, Dept Psychiat, Plovdiv 4002, Bulgaria.; Maes, M (corresponding author), Chulalongkorn Univ, Fac Med, Dept Psychiat, Bangkok 10330, Thailand.; Maes, M (corresponding author), Deakin Univ, IMPACT Strateg Res Ctr, Sch Med, POB 281, Geelong, Vic 3220, Australia.
EM headm2010@yahoo.com; hhadi0615@gmail.com; ggmmyazhra19378@gmail.com;
   dr.michaelmaes@hotmail.com
RI Maes, Michael/B-8546-2011; Kadhem Al-Hakeim, Hussein/G-1151-2011
OI Kadhem Al-Hakeim, Hussein/0000-0001-6143-5196; Maes,
   Michael/0000-0002-2012-871X
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NR 132
TC 10
Z9 10
U1 2
U2 9
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2075-4426
J9 J PERS MED
JI J. Pers. Med.
PD JAN
PY 2022
VL 12
IS 1
AR 23
DI 10.3390/jpm12010023
PG 23
WC Health Care Sciences & Services; Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Health Care Sciences & Services; General & Internal Medicine
GA 7U8NN
UT WOS:000912383700001
PM 35055338
OA gold, Green Published, Green Submitted
DA 2025-06-11
ER

PT J
AU Asbury, EA
   Creed, F
   Collins, P
AF Asbury, EA
   Creed, F
   Collins, P
TI Distinct psychosocial differences between women with coronary heart
   disease and cardiac syndrome X
SO EUROPEAN HEART JOURNAL
LA English
DT Article
DE syndrome X; coronary heart disease; women; psychology
ID ESTROGEN PLUS PROGESTIN; NONCARDIAC CHEST-PAIN; MICROVASCULAR ANGINA;
   POSTMENOPAUSAL WOMEN; ARTERIES; HEALTH; HYSTERECTOMY; DEPRESSION;
   MANAGEMENT; MORBIDITY
AB Aims To compare the impact of oestrogen, gynaecological history, social support, life events and family history of CHD on psychosocial morbidity in syndrome X, CHD patients and healthy controls.
   Methods and Results 100 female syndrome X (60 +/- 9 years), 100 female CHD (65 +/- 9 years) and 100 healthy female volunteers (61 +/- 10 years) completed the hospital anxiety and depression scale (HADS), health anxiety questionnaire (HAQ), a demographic information scale, life events scale, family history of CHD, menopausal, menstrual and gynaecological history. A 17beta-oestradiol sample was taken. Syndrome X patients had higher levels of life interference (p < 0.05) and HADS anxiety (p < 0.05) than CHD patients, and higher levels of all HADS and HAQ scales than controls (p < 0.01). Syndrome X patients with a large social network had lower HADS anxiety (p < 0.05), health worry (p < 0.05), life interference (p < 0.01) and total HAQ (p < 0.01). Social network (p = 0.003), divorced/separated or widowed status (p = 0.005), HRT (p = 0.008) and HADS anxiety score (p < 0.001) accounted for 41.9% of the variance in HAQ scores in syndrome X. Oestrogen was unrelated to the HADS or HAQ for any group.
   Conclusion Syndrome X patients suffered higher Levels of psychological morbidity in comparison to CHD patients and controls. Life events and social network size were related to health anxiety, general anxiety and depression in women with syndrome X. (C) 2004 The European Society of Cardiology. Published by Elsevier Ltd. All rights reserved.
C1 Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, Dept Cardiac Med, London SW3 6LY, England.
   Manchester Royal Infirm, Dept Psychiat, Manchester M13 9WL, Lancs, England.
C3 Imperial College London; University of Manchester
RP Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, Dept Cardiac Med, Dovehouse St, London SW3 6LY, England.
EM e.asbury@ic.ac.uk
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NR 42
TC 59
Z9 64
U1 0
U2 5
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0195-668X
EI 1522-9645
J9 EUR HEART J
JI Eur. Heart J.
PD OCT
PY 2004
VL 25
IS 19
BP 1695
EP 1701
DI 10.1016/j.ehj.2004.07.035
PG 7
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Cardiovascular System & Cardiology
GA 862UB
UT WOS:000224515500007
PM 15451147
DA 2025-06-11
ER

PT J
AU Caceres, BA
   Veldhuis, CB
   Hickey, KT
   Hughes, TL
AF Caceres, Billy A.
   Veldhuis, Cindy B.
   Hickey, Kathleen T.
   Hughes, Tonda L.
TI Lifetime Trauma and Cardiometabolic Risk in Sexual Minority Women
SO JOURNAL OF WOMENS HEALTH
LA English
DT Article
DE sexual minority women; trauma; cardiovascular disease
ID POSTTRAUMATIC-STRESS-DISORDER; INTIMATE PARTNER VIOLENCE; ADVERSE
   CHILDHOOD EXPERIENCES; CARDIOVASCULAR-DISEASE RISK; MASS INDEX
   TRAJECTORIES; VICTIMIZATION EXPERIENCES; MULTIDIMENSIONAL SCALE;
   HAZARDOUS DRINKING; HETEROSEXUAL WOMEN; COMMUNITY SAMPLE
AB Background: Sexual minority women (SMW; such as lesbian, bisexual, and mostly lesbian) exhibit excess cardiometabolic risk, yet factors that contribute to cardiometabolic risk in this population are poorly understood. Trauma exposure has been posited as a contributor to cardiometabolic risk in SMW. Materials and Methods: An analysis of data from Wave 3 of the Chicago Health and Life Experiences of Women Study was conducted. Multinomial logistic regression was used to examine correlates of trauma. Next, multiple logistic regression was used to examine the associations of different forms of trauma throughout the life course (childhood, adulthood, and lifetime), with psychosocial and behavioral risk factors and self-reported cardiometabolic risk (obesity, hypertension, and diabetes) in SMW adjusted for relevant covariates. Results: A total of 547 participants were included. Older age was associated with higher rates of childhood and adulthood trauma. SMW of color reported higher rates of childhood trauma than white participants. Higher education was associated with lower rates of adulthood trauma. All forms of trauma were associated with probable diagnosis of post-traumatic stress disorder and lower perceived social support. Adult trauma was associated with anxiety, whereas childhood and lifetime trauma were associated with higher odds of depression. No significant associations between forms of trauma and behavioral risk factors were noted, except that childhood trauma was associated with higher odds of past-3-month overeating. Logistic regression models examining the association of trauma and cardiometabolic risk revealed that childhood trauma was an independent risk factor for diabetes. Adulthood and lifetime trauma were significantly associated with obesity and hypertension. Conclusions: Trauma emerged as an independent risk factor for cardiometabolic risk in SMW. These findings suggest that clinicians should screen for trauma as a cardiovascular risk factor in SMW, with special attention to SMW most at risk.
C1 [Caceres, Billy A.; Veldhuis, Cindy B.; Hickey, Kathleen T.; Hughes, Tonda L.] Columbia Univ, Sch Nursing, 622 W 168th St, New York, NY 10032 USA.
C3 Columbia University
RP Caceres, BA (corresponding author), Columbia Univ, Sch Nursing, 622 W 168th St, New York, NY 10032 USA.
EM bac2134@cumc.columbia.edu
RI Veldhuis, Cindy/J-7382-2019; Hickey, Kathleen/G-5754-2013
OI Caceres, Billy/0000-0001-6865-5546
FU National Institute on Alcohol Abuse and Alcoholism [R01AA013328];
   training grant on Comparative and Cost-Effectiveness Research from the
   National Institute of Nursing Research [T32NR014205]; NIH/NIAAA Ruth L.
   Kirschstein Post-doctoral Research Fellowship [F32AA025816]
FX Research reported in this publication was supported by the National
   Institute on Alcohol Abuse and Alcoholism under Award Number R01AA013328
   to Dr. Hughes. Dr. Caceres' participation in the research was supported
   by a training grant on Comparative and Cost-Effectiveness Research from
   the National Institute of Nursing Research (T32NR014205). Dr. Veldhuis'
   participation in this research was made possible through an NIH/NIAAA
   Ruth L. Kirschstein Post-doctoral Research Fellowship (F32AA025816).
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NR 86
TC 19
Z9 22
U1 0
U2 10
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-9996
EI 1931-843X
J9 J WOMENS HEALTH
JI J. Womens Health
PD SEP 1
PY 2019
VL 28
IS 9
BP 1200
EP 1217
DI 10.1089/jwh.2018.7381
EA MAY 2019
PG 18
WC Public, Environmental & Occupational Health; Medicine, General &
   Internal; Obstetrics & Gynecology; Women's Studies
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; General & Internal
   Medicine; Obstetrics & Gynecology; Women's Studies
GA IX8WL
UT WOS:000468171200001
PM 31099702
OA Green Published
DA 2025-06-11
ER

PT J
AU Anwar, R
   Rabail, R
   Rakha, A
   Bryla, M
   Roszko, M
   Aadil, RM
   Kieliszek, M
AF Anwar, Rimsha
   Rabail, Roshina
   Rakha, Allah
   Bryla, Marcin
   Roszko, Marek
   Aadil, Rana Muhammad
   Kieliszek, Marek
TI Delving the Role of Caralluma fimbriata: An Edible Wild Plant to
   Mitigate the Biomarkers of Metabolic Syndrome
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Review
ID PREGNANE GLYCOSIDES; OXIDATIVE STRESS; HEXAGONA LAVRANOS; PANCREATIC
   LIPASE; MEDICINAL-PLANTS; HERBAL MEDICINES; ANTIOXIDANT; EXTRACT;
   GLUCOSIDASE; ANTIOBESITY
AB Metabolic syndrome (MS), commonly known as syndrome X or insulin resistance syndrome, is a collection of risk factors for cardiovascular diseases and type II diabetes. MS is believed to impact over a billion individuals worldwide. It is a medical condition defined by visceral obesity, insulin resistance, high blood pressure, and abnormal cholesterol levels, according to the World Health Organization. The current dietary trends are more focused on the use of functional foods and nutraceuticals that are well known for their preventive and curative role against such pathological disorders. Caralluma fimbriata is one such medicinal plant that is gaining popularity. It is a wild, edible, succulent roadside shrub with cactus-like leaves. Besides its main nutrient contents, various bioactive constituents have been identified and linked with positive health outcomes of appetite-suppressing, hypolipidemic, antioxidant, hepatoprotective, and anticancer potentials. Hence, such properties make C. fimbriata an invaluable plant against MS. The current review compiles recent available literature on C. fimbriata's nutritional composition, safety parameters, and therapeutic potential for MS. Summarized data in this review reveals that C. fimbriata remains a neglected plant with limited food and therapeutic applications. Yet various studies explored here do prove its positive health-ameliorating outcomes.
C1 [Anwar, Rimsha; Rabail, Roshina; Rakha, Allah; Aadil, Rana Muhammad] Univ Agr Faisalabad, Natl Inst Food Sci & Technol, Faisalabad 38000, Pakistan.
   [Bryla, Marcin; Roszko, Marek] Prof Waclaw Dabrowski Inst Agr & Food Biotechnol S, Dept Food Safety & Chem Anal, Rakowiecka 36, PL-02532 Warsaw, Poland.
   [Kieliszek, Marek] Warsaw Univ Life Sci SGGW, Inst Food Sci, Dept Food Biotechnol & Microbiol, Nowoursynowska 159 C, PL-02776 Warsaw, Poland.
C3 University of Agriculture Faisalabad; Warsaw University of Life Sciences
RP Rakha, A; Aadil, RM (corresponding author), Univ Agr Faisalabad, Natl Inst Food Sci & Technol, Faisalabad 38000, Pakistan.; Kieliszek, M (corresponding author), Warsaw Univ Life Sci SGGW, Inst Food Sci, Dept Food Biotechnol & Microbiol, Nowoursynowska 159 C, PL-02776 Warsaw, Poland.
EM rimsha.2646@gmail.com; roshina.rabail@gmail.com; arrehman_ft@uaf.edu.pk;
   marcin.bryla@ibprs.pl; marek.roszko@ibprs.pl; muhammad.aadil@uaf.edu.pk;
   marek_kieliszek@sggw.pl
RI Rabail, Roshina/AAU-9839-2021; Kieliszek, Marek/V-4421-2018; Aadil, Rana
   Muhammad/GRY-2404-2022
OI Rakha, Allah/0000-0002-3061-6426; Kieliszek, Marek/0000-0002-5836-4865;
   Rabail, Roshina/0000-0003-1600-5191; Aadil, Rana
   Muhammad/0000-0002-0185-0096
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NR 102
TC 24
Z9 24
U1 2
U2 13
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PD JUN 20
PY 2022
VL 2022
AR 5720372
DI 10.1155/2022/5720372
PG 17
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA 2R2IB
UT WOS:000820932000001
PM 35770046
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Gajewska, A
   Strzelecki, D
   Gawlik-Kotelnicka, O
AF Gajewska, Agata
   Strzelecki, Dominik
   Gawlik-Kotelnicka, Oliwia
TI Ghrelin as a Biomarker of "Immunometabolic Depression" and Its
   Connection with Dysbiosis
SO NUTRIENTS
LA English
DT Review
DE ghrelin; depression; metabolic syndrome; obesity; microbiota
ID DES-ACYL GHRELIN; BODY-MASS INDEX; SERUM GHRELIN; WEIGHT-GAIN; INSULIN
   SENSITIVITY; UNACYLATED GHRELIN; GENE POLYMORPHISM; MAJOR DEPRESSION;
   GLYCEMIC CONTROL; PLASMA GHRELIN
AB Ghrelin, a gastrointestinal peptide, is an endogenous ligand of growth hormone secretagogue receptor 1a (GHSR1a), which is mainly produced by X/A-like cells in the intestinal mucosa. Beyond its initial description as a growth hormone (GH) secretagogue stimulator of appetite, ghrelin has been revealed to have a wide range of physiological effects, for example, the modulation of inflammation; the improvement of cardiac performance; the modulation of stress, anxiety, taste sensation, and reward-seeking behavior; and the regulation of glucose metabolism and thermogenesis. Ghrelin secretion is altered in depressive disorders and metabolic syndrome, which frequently co-occur, but it is still unknown how these modifications relate to the physiopathology of these disorders. This review highlights the increasing amount of research establishing the close relationship between ghrelin, nutrition, microbiota, and disorders such as depression and metabolic syndrome, and it evaluates the ghrelinergic system as a potential target for the development of effective pharmacotherapies.
C1 [Gajewska, Agata] Med Univ Lodz, Fac Med, PL-92216 Lodz, Poland.
   [Strzelecki, Dominik; Gawlik-Kotelnicka, Oliwia] Med Univ Lodz, Dept Affect & Psychot Disorders, PL-92216 Lodz, Poland.
C3 Medical University Lodz; Medical University Lodz
RP Gawlik-Kotelnicka, O (corresponding author), Med Univ Lodz, Dept Affect & Psychot Disorders, PL-92216 Lodz, Poland.
EM agata.gajewska@stud.umed.lodz.pl; dominik.strzelecki@umed.lodz.pl;
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NR 187
TC 9
Z9 9
U1 0
U2 5
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD SEP
PY 2023
VL 15
IS 18
AR 3960
DI 10.3390/nu15183960
PG 21
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA T4PZ7
UT WOS:001077838200001
PM 37764744
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Eschwège, E
AF Eschwège, E
TI The dysmetabolic syndrome, insulin resistance and increased
   cardiovascular (CV) morbidity and mortality in type 2 diabetes::
   aetiological factors in the development of CV complications
SO DIABETES & METABOLISM
LA English
DT Article
DE dysmetabolic syndrome; syndrome X; insulin resistance; clinical
   outcomes; coronary heart disease; type 2 diabetes
ID LOW-DENSITY-LIPOPROTEIN; METABOLIC SYNDROME; ENDOTHELIAL FUNCTION;
   RISK-FACTOR; PROVISIONAL REPORT; OXIDATIVE STRESS; SHORT-TERM; NIDDM;
   DYSFUNCTION; CORONARY
AB Insulin resistance often clusters with other cardiovascular risk factors, such as obesity, impaired glucose tolerance (IGT), hypertension, dyslipidaemia and impaired fibrinolysis. Collectively, these endocrine and metabolic disturbances are described as the dysmetabolic syndrome, which is also commonly called the "insulin resistance syndrome", the "metabolic syndrome", or "syndrome X". Insulin resistance, working in concert with the other components of the dysmetabolic syndrome, induces deleterious changes to the vascular endothelium and lipid profiles that directly and indirectly promote the progression of atherosclerosis. Insulin resistance in adipocytes, leading to decreased suppression of lipolysis by insulin, may be especially important in this regard. Reduced suppression of lipolysis by insulin in obese subjects is associated with increased levels of fatty acids that damage the arterial wall and promote atherosclerosis. The lipid profiles of insulin-resistant subjects are often characterised by the appearance of hypertriglyceridaemia and small, dense LDL-cholesterol, together with low HDL-cholesterol. In addition, adipocytes are highly active endocrine organs and secrete a range of substances that reduce insulin sensitivity further. The net result of these derangements is a vicious circle, wherein the development of insulin resistance is strongly associated with atherogenic lipid profiles and endothelial dysfunction which, in turn, exacerbates insulin resistance. The consequences for the individual with dysmetabolic syndrome include an increased risk of cardiovascular disease of up to 4-fold compared with subjects without the dysmetabolic syndrome.
C1 INSERM, U 258, F-94807 Villejuif, France.
C3 Institut National de la Sante et de la Recherche Medicale (Inserm)
EM eschwege@vjf.inserm.fr
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NR 46
TC 34
Z9 41
U1 0
U2 1
PU MASSON EDITEUR
PI MOULINEAUX CEDEX 9
PA 21 STREET CAMILLE DESMOULINS, ISSY, 92789 MOULINEAUX CEDEX 9, FRANCE
SN 1262-3636
EI 1878-1780
J9 DIABETES METAB
JI Diabetes Metab.
PD SEP
PY 2003
VL 29
IS 4
BP S19
EP S27
PN 2
PG 9
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 732XY
UT WOS:000185971900003
DA 2025-06-11
ER

PT J
AU Hamer, M
   Malan, L
AF Hamer, Mark
   Malan, Leone
TI Sympathetic nervous activity, depressive symptoms, and metabolic
   syndrome in black Africans: The sympathetic activity and ambulatory
   blood pressure in Africans study
SO STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS
LA English
DT Article
DE Cardiometabolic risk; depression; ethnicity; salivary MHPG; Stroop task;
   sympathoadrenal system
ID BODY-FAT DISTRIBUTION; INSULIN-RESISTANCE; OBESITY; SYSTEM; LIFE;
   POPULATION; REACTIVITY; RESPONSES; DISEASE; PLASMA
AB The aim of this study was to examine the association between sympathetic nervous activity, depressive symptoms, and metabolic syndrome in a sample of black and Caucasian Africans. The sample consisted of healthy men and women: 194 blacks (aged, mean +/- SD, 44.1 +/- 7.9 years) and 206 Caucasians (aged, mean +/- SD, 44.7 +/- 10.8 years). Salivary 3-methoxy-phenylglycol (MHPG) concentration, the major metabolite of norepinephrine, was measured during the Stroop mental challenge. Depressive symptoms were assessed from the 9-item Patient Health Questionnaire. Metabolic syndrome (defined as central obesity plus any other two risk factors including raised serum triglycerides, reduced serum high-density lipoprotein-cholesterol, raised blood pressure, and raised fasting plasma glucose) was prevalent in 43.0% and 36.4% of blacks and Caucasians, respectively. In blacks there was, on average, a 16.4% increase in salivary MHPG concentration following mental stress, although no significant response was observed in Caucasians. The salivary MHPG response in blacks was associated with risk of metabolic syndrome (odds ratio [OR] = 1.11, 95% CI, 1.00-1.24) after adjusting for age, sex, and baseline salivary MHPG concentration. This association was mainly driven by the central obesity component of the metabolic syndrome. The salivary MHPG response was also related to moderate-severe depressive symptoms (OR = 1.16, 95% CI, 1.04-1.30), and further adjustment for depressive symptoms attenuated the association between salivary MHPG response and metabolic syndrome (OR = 1.07, 95% CI, 0.96-1.20). These data indicate an association between sympathetic activity, depressive symptoms, and metabolic syndrome in a sample of black Africans.
C1 [Hamer, Mark] UCL, Dept Epidemiol & Publ Hlth, Psychobiol Grp, London WC1E 6BT, England.
   [Malan, Leone] North West Univ, Sch Physiol Nutr & Consumer Sci, HART, Potchefstroom, South Africa.
C3 University of London; University College London; North West University -
   South Africa
RP Hamer, M (corresponding author), UCL, Dept Epidemiol & Publ Hlth, Psychobiol Grp, 1-19 Torrington Pl, London WC1E 6BT, England.
EM m.hamer@ucl.ac.uk
RI Malan, Leone/Q-8187-2019; Hamer, Mark/C-1602-2008; Malan,
   Leone/D-7203-2014
OI Hamer, Mark/0000-0002-8726-7992; Malan, Leone/0000-0003-3187-2410
FU HART (North-West University); National Research Foundation South Africa;
   Metabolic Syndrome Institute, France; British Heart Foundation, UK
FX We thank Chrissie Lessing (research nurse) and Szabolcs Peter (MD) for
   the collection and analysis of data. Dr Hamer had full access to the
   data and took responsibility for the integrity of the data and accuracy
   of the data analyses. He also carried out statistical analyses. Both Dr
   Hamer and Leone Malan contributed to the concept and design of the
   study, drafting, critical revision of the manuscript, and have approved
   the final manuscript. This research was funded by HART (North-West
   University) and National Research Foundation South Africa, Metabolic
   Syndrome Institute, France. Dr Hamer is supported by the British Heart
   Foundation, UK. The funding organizations played no role in the design
   and conduct of the study; collection, management, analysis, and
   interpretation of the data; and preparation, review, or approval of the
   manuscript.
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NR 31
TC 17
Z9 17
U1 0
U2 4
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1025-3890
EI 1607-8888
J9 STRESS
JI Stress
PD SEP
PY 2012
VL 15
IS 5
BP 562
EP 568
DI 10.3109/10253890.2011.648247
PG 7
WC Behavioral Sciences; Endocrinology & Metabolism; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Behavioral Sciences; Endocrinology & Metabolism; Neurosciences &
   Neurology
GA 994AW
UT WOS:000307904200012
PM 22150400
OA Bronze
DA 2025-06-11
ER

PT J
AU Stanton, R
   Happell, B
AF Stanton, Robert
   Happell, Brenda
TI Exercise for mental illness: A systematic review of inpatient studies
SO INTERNATIONAL JOURNAL OF MENTAL HEALTH NURSING
LA English
DT Article
DE inpatient; aerobic; mental health; physical activity; exercise
ID DEPRESSED PSYCHIATRIC-PATIENTS; PHYSICAL HEALTH-CARE; METABOLIC
   SYNDROME; PROGRAM; SCHIZOPHRENIA; OBESITY; PEOPLE; COHORT
AB A substantial body of evidence supports the role of exercise interventions for people with a mental illness. However, much of this literature is conducted using outpatient and community-based populations. We undertook a systematic review examining the effect of exercise interventions on the health of people hospitalized with depression, schizophrenia, bipolar disorder, or anxiety disorders. Eight studies met our inclusion criteria. Several studies show positive health outcomes from short-term and long-term interventions for people hospitalized due to depression. Although positive, the evidence for inpatients with schizophrenia, bipolar disorder, or anxiety disorders is substantially less. There is an urgent need to address the paucity of literature in this area, in particular the optimal dose and delivery of exercise for people hospitalized as a result of mental illness. Standardization of reporting exercise programme variables, the assessment of mental illness, and the reporting of adverse events must accompany future studies.
C1 [Stanton, Robert; Happell, Brenda] Cent Queensland Univ, Sch Nursing & Midwifery, Ctr Mental Hlth Nursing Innovat, Inst Hlth & Social Sci Res, Rockhampton, Qld 4072, Australia.
C3 Central Queensland University
RP Stanton, R (corresponding author), Cent Queensland Univ, Sch Nursing & Midwifery, Ctr Mental Hlth Nursing Innovat, Inst Hlth & Social Sci Res, Rockhampton, Qld 4072, Australia.
RI Stanton, Rob/AAJ-5157-2020; Happell, Brenda/HSI-0570-2023
OI Happell, Brenda/0000-0002-7293-6583
CR [Anonymous], DEPR TREATM MAN DEPR
   [Anonymous], NAT HLTH WORKF SER
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NR 31
TC 56
Z9 64
U1 2
U2 52
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1445-8330
EI 1447-0349
J9 INT J MENT HEALTH NU
JI Int. J. Ment. Health Nurs.
PD JUN
PY 2014
VL 23
IS 3
BP 232
EP 242
DI 10.1111/inm.12045
PG 11
WC Nursing; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Psychiatry
GA AE6SE
UT WOS:000334124000006
PM 24119136
DA 2025-06-11
ER

PT J
AU Shakya, S
   Bajracharya, R
   Ledbetter, L
   Cary, MP 
AF Shakya, Shamatree
   Bajracharya, Rashmita
   Ledbetter, Leila
   Cary, Michael P., Jr.
TI The Association Between Cardiometabolic Risk Factors and Frailty in
   Older Adults: A Systematic Review
SO INNOVATION IN AGING
LA English
DT Review
DE Cardiometabolic risk factors; Frailty; Inflammation; Older adults
ID OXIDATIVE STRESS; INFLAMMATORY MARKERS; INSULIN-RESISTANCE; METABOLIC
   SYNDROME; ABDOMINAL OBESITY; HYPERGLYCEMIA; COMPONENTS; DISEASE; HEALTH
AB Background and Objectives Enhanced management and prevention of frailty depend on our understanding of the association between potentially modifiable risk factors and frailty. However, the associations between potentially modifiable cardiometabolic risk factors and frailty are not clear. The purpose of this review was to appraise and synthesize the current evidence examining the associations between the cardiometabolic risk factors and frailty. Research Design and Methods Multiple databases, including MEDLINE (via PubMed), Embase (via Elsevier), and Web of Science (via Clarivate), were searched extensively. Studies that examined cardiometabolic risk factors and frailty as main predictors and outcome of interest, respectively, among older adults (>= 60 years) were included. The Joanna Briggs Institute critical appraisal tools were used to evaluate the quality of studies. PRISMA (2020) guided this review, and findings were synthesized without meta-analysis. This systematic review was registered in PROSPERO (CRD42021252565). Results Twelve studies met the eligibility criteria and were included in the review. Abdominal obesity, hyperglycemia, and multiple co-occurring cardiometabolic risk factors were associated with the increased likelihood of frailty in older adults. There was inconsistency across the studies regarding the associations between dyslipidemia, elevated blood pressure, and frailty. Discussion and Implications Understanding the association between cardiometabolic risk factors and frailty can have translational benefits in developing tailored interventions for the prevention and management of frailty. More studies are needed to validate predictive and clinically significant associations between single and specific combinations of co-occurring cardiometabolic risk factors and frailty.
C1 [Shakya, Shamatree; Cary, Michael P., Jr.] Duke Univ, Sch Nursing, 307 Trent Dr, Durham, NC 27710 USA.
   [Bajracharya, Rashmita] Univ Maryland, Sch Med, Baltimore, MD USA.
   [Ledbetter, Leila] Duke Univ, Med Ctr Lib & Arch, Sch Med, Durham, NC USA.
C3 Duke University; University System of Maryland; University of Maryland
   Baltimore; Duke University
RP Shakya, S (corresponding author), Duke Univ, Sch Nursing, 307 Trent Dr, Durham, NC 27710 USA.
EM shamatree.shakya@duke.edu
RI ; Ledbetter, Leila/N-9513-2014
OI cary, michael/0000-0002-7966-7515; Bajracharya,
   Rashmita/0000-0002-2663-1367; Shakya, Shamatree/0000-0002-3114-6745;
   Ledbetter, Leila/0000-0002-5206-8002
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NR 64
TC 13
Z9 14
U1 3
U2 25
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
EI 2399-5300
J9 INNOV AGING
JI Innov. Aging
PD JUL 1
PY 2022
VL 6
IS 5
AR igac032
DI 10.1093/geroni/igac032
EA JUL 2022
PG 15
WC Geriatrics & Gerontology; Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Geriatrics & Gerontology
GA 2P8DE
UT WOS:000819963600002
PM 35795135
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Menendez, ME
   Neuhaus, V
   Bot, AGJ
   Ring, D
   Cha, TD
AF Menendez, Mariano E.
   Neuhaus, Valentin
   Bot, Arjan G. J.
   Ring, David
   Cha, Thomas D.
TI Psychiatric Disorders and Major Spine Surgery Epidemiology and
   Perioperative Outcomes
SO SPINE
LA English
DT Article
DE spinal fusion; laminectomy; depression; anxiety; schizophrenia;
   dementia; perioperative; complications; risk factors; mortality;
   discharge; epidemiology
ID UNITED-STATES TRENDS; QUALITY-OF-LIFE; DEPRESSIVE SYMPTOMS; METABOLIC
   SYNDROME; FUSION SURGERY; RISK-FACTORS; MORTALITY; HEALTH; DEMENTIA;
   DISEASE
AB Study Design. Analysis of the National Hospital Discharge Survey database from 1990 to 2007.
   Objective. To evaluate the influence of preoperative depression, anxiety, schizophrenia, or dementia on in-hospital (1) adverse events, (2) mortality, and (3) nonroutine discharge in patients undergoing major spine surgery.
   Summary of Background Data. Psychiatric comorbidity is a known risk factor for impaired health-related quality of life and poor long-term outcomes after spine surgery, yet little is known about its impact in the perioperative spine surgery setting.
   Methods. Using the National Hospital Discharge Survey database, all patients undergoing either spinal fusion or laminectomy between 1990 and 2007 were identified and separated into groups with and without psychiatric disorders. Multivariable regression analysis was performed for each of the outcome variables.
   Results. Between 1990 and 2007, a total estimated number of 5,382,343 spinal fusions and laminectomies were performed. The prevalence of diagnosed depression, anxiety, and schizophrenia among the study population increased significantly over time. Depression, anxiety, schizophrenia, and dementia were associated with higher rates of nonroutine discharge. Depression, schizophrenia, and dementia were associated with higher rates of adverse events. Dementia was the only psychiatric disorder associated with a higher risk of in-hospital mortality.
   Conclusion. Patients with preoperative psychiatric disorders undergoing major spine surgery are at increased risk for perioperative adverse events and posthospitalization care, but its effect in perioperative mortality is more limited. Presurgical psychological screening of candidates undergoing spine surgery might ultimately lead to the enhancement of perioperative outcomes in this growing segment of the US population.
C1 [Menendez, Mariano E.; Neuhaus, Valentin; Bot, Arjan G. J.; Ring, David] Massachusetts Gen Hosp, Orthopaed Hand & Upper Extrem Serv, Boston, MA 02114 USA.
   [Cha, Thomas D.] Orthopaed Spine Serv, Boston, MA USA.
C3 Harvard University; Harvard University Medical Affiliates; Massachusetts
   General Hospital
RP Cha, TD (corresponding author), Massachusetts Gen Hosp, Yawkey Ctr, Orthopaed Spine Serv, Ste 3A,55 Fruit St, Boston, MA 02114 USA.
EM tcha@partners.org
RI Ring, David/AAV-9035-2021
OI Neuhaus, Valentin/0000-0003-4012-5628
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NR 50
TC 116
Z9 120
U1 0
U2 9
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0362-2436
EI 1528-1159
J9 SPINE
JI SPINE
PD JAN 15
PY 2014
VL 39
IS 2
BP E111
EP E122
DI 10.1097/BRS.0000000000000064
PG 12
WC Clinical Neurology; Orthopedics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Orthopedics
GA AH5ZQ
UT WOS:000336210800007
PM 24108288
DA 2025-06-11
ER

PT J
AU Jurado-Fasoli, L
   Di, XY
   Kohler, I
   Osuna-Prieto, FJ
   Hankemeier, T
   Krekels, E
   Harms, AC
   Yang, W
   Garcia-Lario, J
   Fernández-Veledo, S
   Ruiz, JR
   Rensen, PCN
   Martinez-Tellez, B
AF Jurado-Fasoli, Lucas
   Di, Xinyu
   Kohler, Isabelle
   Osuna-Prieto, Francisco J.
   Hankemeier, Thomas
   Krekels, Elke
   Harms, Amy C.
   Yang, Wei
   Garcia-Lario, Jose, V
   Fernandez-Veledo, Sonia
   Ruiz, Jonatan R.
   Rensen, Patrick C. N.
   Martinez-Tellez, Borja
TI Omega-6 and omega-3 oxylipins as potential markers of cardiometabolic
   risk in young adults
SO OBESITY
LA English
DT Article
ID BROWN ADIPOSE-TISSUE; INDUCED LIPOKINE; LIPID MEDIATORS; INFLAMMATION;
   RESOLUTION; 12,13-DIHOME; OBESITY
AB Objective Omega-6 and omega-3 oxylipins are known to play a role in inflammation and cardiometabolic diseases in preclinical models. The associations between plasma levels of omega-6 and omega-3 polyunsaturated fatty acid-derived oxylipins and body composition and cardiometabolic risk factors in young adults were assessed. Methods Body composition, brown adipose tissue, traditional serum cardiometabolic risk factors, inflammatory markers, and a panel of 83 oxylipins were analyzed in 133 young adults (age 22.1[SD 2.2] years, 67% women). Results Plasma levels of four omega-6 oxylipins (15-HeTrE, 5-HETE, 14,15-EpETrE, and the oxidative stress-derived 8,12-iso-iPF(2 alpha)-VI) correlated positively with adiposity, prevalence of metabolic syndrome, fatty liver index, and homeostatic model assessment of insulin resistance index and lipid parameters. By contrast, the plasma levels of three omega-3 oxylipins (14,15-DiHETE, 17,18-DiHETE, and 19,20-DiHDPA) were negatively correlated with adiposity, prevalence of metabolic syndrome, fatty liver index, homeostatic model assessment of insulin resistance index, and lipid parameters. The panel of seven oxylipins predicted adiposity better than traditional inflammatory markers such as interferon gamma or tumor necrosis factor-alpha. Pathway analyses revealed that individuals with obesity had higher plasma levels of omega-6 and lower plasma levels of omega-3 oxylipins than normal-weight individuals. Conclusion Plasma levels of seven omega-6 and omega-3 oxylipins may have utility as early markers of cardiometabolic risk in young adults.
C1 [Jurado-Fasoli, Lucas; Osuna-Prieto, Francisco J.; Ruiz, Jonatan R.; Martinez-Tellez, Borja] Univ Granada, Sport & Hlth Univ Res Inst iMUDS, Dept Phys Educ & Sports,Fac Sport Sci, PROmoting FITness & Hlth Phys Act Res Grp PROFITH, Granada, Spain.
   [Di, Xinyu; Hankemeier, Thomas; Krekels, Elke; Harms, Amy C.; Yang, Wei] Leiden Univ, Leiden Acad Ctr Drug Res LACDR, Dept Syst Biomed & Pharmacol, Leiden, Netherlands.
   [Kohler, Isabelle] Vrije Univ Amsterdam, Amsterdam Inst Mol & Life Sci AIMMS, Div BioAnalyt Chem, Amsterdam, Netherlands.
   [Kohler, Isabelle] Ctr Analyt Sci Amsterdam, Amsterdam, Netherlands.
   [Osuna-Prieto, Francisco J.] Univ Granada, Dept Analyt Chem, Granada, Spain.
   [Osuna-Prieto, Francisco J.] Res & Dev Funct Food Ctr CIDAF, Granada, Spain.
   [Garcia-Lario, Jose, V] Hosp Campus Salud, Clin Lab, Granada, Spain.
   [Fernandez-Veledo, Sonia] Univ Hosp Tarragona Joan XXIII, Inst Invest Sanitaria Pere Virgili IISPV, Dept Endocrinol & Nutr, Tarragona, Spain.
   [Fernandez-Veledo, Sonia] Univ Hosp Tarragona Joan XXIII, Inst Invest Sanitaria Pere Virgili IISPV, Res Unit, Tarragona, Spain.
   [Fernandez-Veledo, Sonia] Inst Salud Carlos III, CIBER Diabet & Enfermedades Metab Asociadas CIBER, Madrid, Spain.
   [Rensen, Patrick C. N.; Martinez-Tellez, Borja] Leiden Univ, Med Ctr, Div Endocrinol, Dept Med, Leiden, Netherlands.
   [Rensen, Patrick C. N.; Martinez-Tellez, Borja] Leiden Univ, Med Ctr, Einthoven Lab Expt Vasc Med, Leiden, Netherlands.
C3 University of Granada; Leiden University - Excl LUMC; Leiden University;
   Vrije Universiteit Amsterdam; University of Granada; Universitat Rovira
   i Virgili; Institut d'Investigacio Sanitaria Pere Virgili (IISPV);
   Universitat Rovira i Virgili; Institut d'Investigacio Sanitaria Pere
   Virgili (IISPV); Instituto de Salud Carlos III; CIBER - Centro de
   Investigacion Biomedica en Red; CIBERES; Leiden University - Excl LUMC;
   Leiden University; Leiden University Medical Center (LUMC); Leiden
   University - Excl LUMC; Leiden University; Leiden University Medical
   Center (LUMC)
RP Ruiz, JR; Martinez-Tellez, B (corresponding author), Univ Granada, Sport & Hlth Univ Res Inst iMUDS, Dept Phys Educ & Sports,Fac Sport Sci, PROmoting FITness & Hlth Phys Act Res Grp PROFITH, Granada, Spain.
EM ruizj@ugr.es; b.martinez-tellez@lumc.nl
RI Hankemeier, Thomas/V-5407-2019; fernie, alisdair/IWD-9278-2023; Tellez,
   Borja/R-5770-2019; Osuna Prieto, Francisco Javier/AGQ-5063-2022; Fasoli,
   Lucas/AAC-5217-2019
OI Yang, Wei/0000-0002-3394-7570; Kohler, Isabelle/0000-0002-3629-1597;
   Jurado-Fasoli, Lucas/0000-0002-5254-1816; Hankemeier,
   Thomas/0000-0001-7871-2073; Osuna-Prieto, Francisco
   J./0000-0002-6546-9534
FU Spanish Ministry of Economy and Competitiveness via the Fondo de
   Investigacion Sanitaria del Instituto de Salud Carlos III [PI13/01393];
   Retos de la Sociedad [DEP2016-79512-R]; European Regional Development
   Fund (ERDF); Spanish Ministry of Education [FPU16/02828, FPU19/01609];
   Fundacion Iberoamericana de Nutricion (FINUT); Redes Tematicas de
   Investigacion Cooperativa RETIC [Red SAMID RD16/0022]; AstraZeneca
   HealthCare Foundation; University of Granada Plan Propio de
   Investigacion Excellence actions: Unit of Excellence on Exercise and
   Health (UCEES); Junta de Andalucia; Consejeria de Conocimiento,
   Investigacion y Universidades (ERDF) [SOMM17/6107/UGR, DOC 01151];
   Fundacion Alfonso Martin Escudero; Netherlands CardioVascular Research
   Initiative: the Dutch Heart Foundation; Dutch Federation of University
   Medical Centers; Netherlands Organisation for Health Research and
   Development; Royal Netherlands Academy of Sciences [CVON2017-20
   GENIUS-2]; Chinese Scholarship Council (CSC) [201707060012]; 
   [PTA-12264]
FX This study was supported by the Spanish Ministry of Economy and
   Competitiveness via the Fondo de Investigacion Sanitaria del Instituto
   de Salud Carlos III (PI13/01393) and PTA-12264, Retos de la Sociedad
   (DEP2016-79512-R) and the European Regional Development Fund (ERDF), the
   Spanish Ministry of Education (FPU16/02828 and FPU19/01609), the
   Fundacion Iberoamericana de Nutricion (FINUT), the Redes Tematicas de
   Investigacion Cooperativa RETIC (Red SAMID RD16/0022), the AstraZeneca
   HealthCare Foundation, the University of Granada Plan Propio de
   Investigacion 2016 Excellence actions: Unit of Excellence on Exercise
   and Health (UCEES), the Junta de Andalucia, Consejeria de Conocimiento,
   Investigacion y Universidades (ERDF; ref. SOMM17/6107/UGR and DOC
   01151), the Fundacion Alfonso Martin Escudero, the Netherlands
   CardioVascular Research Initiative: the Dutch Heart Foundation, Dutch
   Federation of University Medical Centers, the Netherlands Organisation
   for Health Research and Development and the Royal Netherlands Academy of
   Sciences (CVON2017-20 GENIUS-2) to PCNR, and the Chinese Scholarship
   Council (CSC, No. 201707060012).
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NR 45
TC 25
Z9 26
U1 1
U2 18
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1930-7381
EI 1930-739X
J9 OBESITY
JI Obesity
PD JAN
PY 2022
VL 30
IS 1
BP 50
EP 61
DI 10.1002/oby.23282
EA DEC 2021
PG 12
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA XR2JR
UT WOS:000729319700001
PM 34898010
OA Green Published
DA 2025-06-11
ER

PT J
AU Jeitler, M
   Lauche, R
   Hohmann, C
   Choi, KE
   Schneider, N
   Steckhan, N
   Rathjens, F
   Anheyer, D
   Paul, A
   von Scheidt, C
   Ostermann, T
   Schneider, E
   Koppold-Liebscher, D
   Kessler, CS
   Dobos, G
   Michalsen, A
   Cramer, H
AF Jeitler, Michael
   Lauche, Romy
   Hohmann, Christoph
   Choi, Kyung-Eun (anna)
   Schneider, Nadia
   Steckhan, Nico
   Rathjens, Florian
   Anheyer, Dennis
   Paul, Anna
   von Scheidt, Christel
   Ostermann, Thomas
   Schneider, Elisabeth
   Koppold-Liebscher, Daniela
   Kessler, Christian S.
   Dobos, Gustav
   Michalsen, Andreas
   Cramer, Holger
TI A Randomized Controlled Trial of Fasting and Lifestyle Modification in
   Patients with Metabolic Syndrome: Effects on Patient-Reported Outcomes
SO NUTRIENTS
LA English
DT Article
DE fasting; metabolic syndrome; modified DASH diet; Mediterranean diet;
   lifestyle; relaxation; mindfulness; MICOM (Mind-Body Medicine in
   Integrative and Complementary Medicine); self-efficacy
ID CORONARY-ARTERY-DISEASE; RISK-FACTORS; CARDIOVASCULAR-DISEASE; SECONDARY
   PREVENTION; STRESS REDUCTION; GERMAN VERSION; DIET; MINDFULNESS; SCALE;
   MOOD
AB Lifestyle interventions can have a positive impact on quality of life and psychological parameters in patients with metabolic syndrome (MetS). In this randomized controlled trial, 145 participants with MetS (62.8% women; 59.7 +/- 9.3 years) were randomized to (1) 5-day fasting followed by 10 weeks of lifestyle modification (F + LM; modified DASH diet, exercise, mindfulness; n = 73) or (2) 10 weeks of lifestyle modification only (LM; n = 72). Outcomes were assessed at weeks 0, 1, 12, and 24, and included quality of life (Short-Form 36 Health Survey Questionnaire, SF-36), anxiety/depression (Hospital Anxiety and Depression Scale, HADS), stress (Cohen Perceived Stress Scale, CPSS), mood (Profile of Mood States, POMS), self-efficacy (General Self-Efficacy Scale, GSE), mindfulness (Mindfulness Attention Awareness Scale, MAAS), and self-compassion (Self-Compassion Scale, SCS). At week 1, POMS depression and fatigue scores were significantly lower in F + LM compared to LM. At week 12, most self-report outcomes improved in both groups-only POMS vigor was significantly higher in F + LM than in LM. Most of the beneficial effects within the groups persisted at week 24. Fasting can induce mood-modulating effects in the short term. LM induced several positive effects on quality of life and psychological parameters in patients with MetS.
C1 [Jeitler, Michael; Hohmann, Christoph; Steckhan, Nico; Schneider, Elisabeth; Kessler, Christian S.; Michalsen, Andreas] Charite Univ Med Berlin, Inst Social Med Epidemiol & Hlth Econ, D-10117 Berlin, Germany.
   [Jeitler, Michael; Hohmann, Christoph; Steckhan, Nico; Schneider, Elisabeth; Kessler, Christian S.; Michalsen, Andreas] Free Univ Berlin, D-10117 Berlin, Germany.
   [Jeitler, Michael; Hohmann, Christoph; Steckhan, Nico; Schneider, Elisabeth; Kessler, Christian S.; Michalsen, Andreas] Humboldt Univ, D-10117 Berlin, Germany.
   [Jeitler, Michael; von Scheidt, Christel; Koppold-Liebscher, Daniela; Kessler, Christian S.; Michalsen, Andreas] Immanuel Hosp Berlin, Dept Internal & Integrat Med, D-14109 Berlin, Germany.
   [Lauche, Romy; Cramer, Holger] Southern Cross Univ, Natl Ctr Naturopath Med, Lismore, NSW 2480, Australia.
   [Choi, Kyung-Eun (anna)] Brandenburg Med Sch Theodor Fontane, Ctr Hlth Serv Res, D-16816 Neuruppin, Germany.
   [Schneider, Nadia; Rathjens, Florian; Anheyer, Dennis; Paul, Anna; Dobos, Gustav; Cramer, Holger] Univ Duisburg Essen, Evang Kliniken Essen Mitte, Dept Internal & Integrat Med, D-45276 Essen, Germany.
   [Steckhan, Nico] Univ Potsdam, Digital Hlth Ctr, Hasso Plattner Inst, D-14482 Potsdam, Germany.
   [Ostermann, Thomas] Witten Herdecke Univ, Dept Psychol & Psychotherapy, D-58455 Witten, Germany.
   [Cramer, Holger] Univ Hosp Tuebingen, Inst Gen Practice & Interprofess Care, D-72076 Tubingen, Germany.
   [Cramer, Holger] Bosch Hlth Campus, D-70376 Stuttgart, Germany.
C3 Berlin Institute of Health; Free University of Berlin; Humboldt
   University of Berlin; Charite Universitatsmedizin Berlin; Free
   University of Berlin; Humboldt University of Berlin; Southern Cross
   University; University of Duisburg Essen; University of Potsdam;
   Eberhard Karls University of Tubingen; Eberhard Karls University
   Hospital
RP Jeitler, M (corresponding author), Charite Univ Med Berlin, Inst Social Med Epidemiol & Hlth Econ, D-10117 Berlin, Germany.; Jeitler, M (corresponding author), Free Univ Berlin, D-10117 Berlin, Germany.; Jeitler, M (corresponding author), Humboldt Univ, D-10117 Berlin, Germany.; Jeitler, M (corresponding author), Immanuel Hosp Berlin, Dept Internal & Integrat Med, D-14109 Berlin, Germany.
EM michael.jeitler@charite.de
RI Lauche, Romy/AAQ-7175-2021; Cramer, Holger/HPG-1828-2023; Kessler,
   Christian/KMX-3377-2024; Ostermann, Thomas/LSK-7444-2024; Choi,
   Kyung-Eun/HCH-2157-2022; Koppold, Daniela/HRC-4226-2023
OI Steckhan, Nico/0000-0003-0245-2046; Ostermann,
   Thomas/0000-0003-2695-0701; Anheyer, Dennis/0000-0001-9310-8077; Choi,
   Kyung-Eun (Anna)/0000-0001-5533-7450; Jeitler,
   Michael/0000-0003-3277-9090; Lauche, Romy/0000-0002-4171-7935; Kessler,
   Christian/0000-0001-7794-8375; Koppold, Daniela/0000-0003-3367-3327
FU Corona-Foundation, Germany [S199/10056/2012]; Open Access Publication
   Fund of Charite-Universitatsmedizin Berlin; German Research Foundation
   (DFG)
FX This work was supported by Corona-Foundation, Germany (funding number:
   S199/10056/2012). The funder had no role in the design and conduct of
   the study; collection, management, analysis, and interpretation of the
   data; preparation, review, or approval of the manuscript; ordecision to
   submit the manuscript for publication. We acknowledge financial support
   from the Open Access Publication Fund of Charite-Universitatsmedizin
   Berlin and the German Research Foundation (DFG).
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NR 56
TC 5
Z9 6
U1 3
U2 6
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD SEP
PY 2022
VL 14
IS 17
AR 3559
DI 10.3390/nu14173559
PG 14
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 4K0TE
UT WOS:000851672800001
PM 36079816
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Hackett, D
   Fitzgerald, C
AF Hackett, Debbie
   Fitzgerald, Catriona
TI Improving and standardizing metabolic screening for people prescribed
   antipsychotic medication who are at risk of developing metabolic
   syndrome within the community mental health setting
SO INTERNATIONAL JOURNAL OF MENTAL HEALTH NURSING
LA English
DT Article
DE antipsychotic medication; community mental health; metabolic screening;
   metabolic syndrome
ID SCHIZOPHRENIA; MANAGEMENT
AB Aim and objective of the audit. The purpose of this audit was to identify the number of people prescribed antipsychotic medication who are at risk of developing metabolic syndrome in a community mental health service area with the aim of improving and standardising metabolic screening practices within this setting. Community mental health services are secondary care services in which individuals are referred from Primary Care (General Practitioners). The catchment area of this audit is within the South East Region of Ireland and offers adults community mental health services to a population of approximately 57 000. For the purpose of this audit we focused on one community mental health team within the service.
C1 [Hackett, Debbie; Fitzgerald, Catriona] Carlow Mental Hlth Serv, Carlow, Ireland.
RP Hackett, D (corresponding author), St Dympnas Hosp, Carlow Mental Hlth Serv, Athy Rd, Carlow R93 DE62, Ireland.
EM Debbie.hackett@hse.ie
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NR 22
TC 0
Z9 2
U1 0
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1445-8330
EI 1447-0349
J9 INT J MENT HEALTH NU
JI Int. J. Ment. Health Nurs.
PD OCT
PY 2020
VL 29
IS 5
BP 935
EP 941
DI 10.1111/inm.12728
EA JUN 2020
PG 7
WC Nursing; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Psychiatry
GA NT0FX
UT WOS:000541504700001
PM 32567189
DA 2025-06-11
ER

PT J
AU Arms, T
   Bostic, T
   Cunningham, P
AF Arms, Tamatha
   Bostic, Tawanda
   Cunningham, Patricia
TI Educational Intervention to Increase Detection of Metabolic Syndrome in
   Patients at Community Mental Health Centers
SO JOURNAL OF PSYCHOSOCIAL NURSING AND MENTAL HEALTH SERVICES
LA English
DT Article
AB The prevalence of metabolic syndrome and associated illness is approximately double in individuals with mental illness compared with the general public. An educational intervention on metabolic syndrome was provided to mental health counselors, who performed intake assessments of patients newly admitted to two outpatient mental health facilities. Researchers of the current study first measured mastery of metabolic syndrome content following the educational intervention; they then conducted a chart audit on new admissions to measure changes in clinician behavior. Prior to the intervention, neither facility screened for metabolic syndrome at intake or referred patients with a body mass index (BMI) >25 for medical evaluation. A paired t test showed no significant difference in the educational pre-posttest scores; however, following the intervention, 53 of 132 patients had a documented BMI >25, and 47 of 53 patients were referred to a primary care provider for evaluation. The current study's findings suggest that mental health counselors who screen for metabolic syndrome and associated illnesses will increase the rate of detection of these chronic conditions.
C1 [Arms, Tamatha] Univ N Carolina, Coll Hlth & Human Serv, Wilmington, NC 28403 USA.
   [Bostic, Tawanda] United Hlth Grp, Charlotte, NC USA.
   [Cunningham, Patricia] Amer Psychiat Nurses Assoc, Falls Church, VA USA.
   [Cunningham, Patricia] Univ Memphis, Loewenberg Sch Nursing, Memphis, TN 38152 USA.
C3 University of North Carolina; University of North Carolina Wilmington;
   University of Memphis
RP Arms, T (corresponding author), Univ N Carolina, Coll Hlth & Human Serv, 3052 McNeill Hall,601 S Coll Rd, Wilmington, NC 28403 USA.
EM armst@uncw.edu
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NR 11
TC 0
Z9 1
U1 0
U2 5
PU SLACK INC
PI THOROFARE
PA 6900 GROVE RD, THOROFARE, NJ 08086 USA
SN 0279-3695
EI 1938-2413
J9 J PSYCHOSOC NURS MEN
JI J. Psychosoc. Nurs. Ment. Health Serv.
PD SEP
PY 2014
VL 52
IS 9
BP 32
EP 36
DI 10.3928/02793695-20140703-01
PG 5
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA AT6QU
UT WOS:000345064600012
PM 25019253
DA 2025-06-11
ER

PT J
AU Sarapultsev, A
   Gusev, E
   Chereshnev, V
   Komelkova, M
   Hu, DS
AF Sarapultsev, Alexey
   Gusev, Evgenii
   Chereshnev, Valeriy
   Komelkova, Maria
   Hu, Desheng
TI Neuroimmune Interactions in Stress and Depression: Exploring the
   Molecular and Cellular Mechanisms within the
   Neuroinflammation-depression Nexus
SO CURRENT MEDICINAL CHEMISTRY
LA English
DT Review; Early Access
DE Chronic stress; depression; neuroimmunoinflammatory stress model (niis);
   neuroinflammation; molecular mechanisms; cellular pathways;
   psychoneuroimmunology; allostatic load; stress-depression
   interconnection; therapeutic interventions
ID LOW-GRADE INFLAMMATION; SYSTEMIC INFLAMMATION; ALLOSTATIC LOAD; IMPAIRED
   NEUROGENESIS; MATTER ABNORMALITIES; PSYCHOLOGICAL STRESS;
   CLINICAL-APPLICATION; ALZHEIMERS-DISEASE; METABOLIC SYNDROME; BRAIN
   STRUCTURE
AB Background The escalating global burden of stress and depression underscores an urgent need to unravel their complex interrelationships and underlying mechanisms. This investigation delves into the intricate dynamics between stress and depression, spotlighting the Neuroimmunoinflammatory Stress Model (NIIS), which elucidates the pivotal role of cellular and molecular pathways in mediating these conditions.Methods Through an exhaustive review of literature spanning epidemiology, neurobiology, and psychoneuroimmunology, this study synthesizes the current understanding of stress and depression. It accentuates the definitional scopes, interplay, and intricacies of the NIIS model, which integrates neuroimmune-inflammatory responses into the conceptual framework of the stress-depression interaction.Results By identifying stress as a multifactorial reaction to perceived adversities and depression as a manifestation of prolonged stress exposure, our analysis foregrounds the NIIS model. This paradigmatic model reveals the transition from normal stress responses to pathological neuroinflammatory pathways, highlighting neurotransmitter imbalances, disruptions in neuronal and glial homeostasis, and ensuing low-grade neuroinflammation as key factors in the pathogenesis of depression under chronic stress conditions. The NIIS model identifies prolonged cellular pro-inflammatory stress of neurons and microglia as a fundamental pathological subsystem of many neuropsychiatric disorders. In turn, neuroinflammation and associated neurodegenerative processes are complications of chronic psychoemotional stress, which can clinically manifest as depression.Conclusions The NIIS model views depression as the terminal stage of chronic stress, pathogenetically linked to latent neuroinflammation. This insight not only advances our understanding of their etiopathogenesis but also paves the way for developing precise therapeutic interventions.
C1 [Sarapultsev, Alexey; Gusev, Evgenii; Chereshnev, Valeriy] Russian Acad Sci, Inst Immunol & Physiol, Ural Branch, Ekaterinburg 620049, Russia.
   [Komelkova, Maria] South Ural State Univ, Russian Chinese Educ & Res Ctr Syst Pathol, Chelyabinsk 454080, Russia.
   [Hu, Desheng] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Integrated Tradit Chinese & Western Med, Wuhan 430022, Peoples R China.
   [Hu, Desheng] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Hubei Key Lab Biol Targeted Therapy, Wuhan 430022, Peoples R China.
   [Hu, Desheng] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, China Russia Med Res Ctr Stress Immunol, Wuhan 430022, Peoples R China.
C3 Russian Academy of Sciences; Institute of Immunology & Physiology UB
   RAS; South Ural State University; Huazhong University of Science &
   Technology; Huazhong University of Science & Technology; Huazhong
   University of Science & Technology
RP Gusev, E (corresponding author), Russian Acad Sci, Inst Immunol & Physiol, Ural Branch, Ekaterinburg 620049, Russia.
EM gusev36@mail.ru
RI Komelkova, Maria/M-6294-2016; Sarapultsev, Alexey/K-7220-2012; Gusev,
   Evgenii/AAE-1536-2021; Chereshnev, Valeriy A. (or "Valerii" or "Valerii"
   or "Valery" or "V.A."/P-7704-2017
OI Gusev, Evgenii/0000-0002-7145-2376; Chereshnev, Valeriy A. (or "Valerii"
   or "Valerii" or "Valery" or "V.A."/0000-0003-4329-147X
FU South Ural State University [FENU-2023-0014]; Institute of Immunology
   and Physiology theme [122020900136-4]
FX This work was funded by South Ural State University, scientific theme
   No. FENU-2023-0014 and partly by the Institute of Immunology and
   Physiology theme No. 122020900136-4.
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NR 183
TC 1
Z9 1
U1 11
U2 16
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 0929-8673
EI 1875-533X
J9 CURR MED CHEM
JI Curr. Med. Chem.
PD 2024 SEP 30
PY 2024
DI 10.2174/0109298673320710240920055041
EA SEP 2024
PG 24
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Pharmacology &
   Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
GA H9Y3Z
UT WOS:001326914200001
PM 39350557
DA 2025-06-11
ER

PT J
AU Li, N
   Liu, Y
   Papandonatos, GD
   Calafat, AM
   Eaton, CB
   Kelsey, KT
   Cecil, KM
   Kalkwarf, HJ
   Yolton, K
   Lanphear, BP
   Chen, AM
   Braun, JM
AF Li, Nan
   Liu, Yun
   Papandonatos, George D.
   Calafat, Antonia M.
   Eaton, Charles B.
   Kelsey, Karl T.
   Cecil, Kim M.
   Kalkwarf, Heidi J.
   Yolton, Kimberly
   Lanphear, Bruce P.
   Chen, Aimin
   Braun, Joseph M.
TI Gestational and childhood exposure to per- and polyfluoroalkyl
   substances and cardiometabolic risk at age 12 years
SO ENVIRONMENT INTERNATIONAL
LA English
DT Article
DE PFAS; Adolescents; Cardiometabolic risk
ID PERFLUOROOCTANE SULFONATE PFOS; LIPOPROTEIN-CHOLESTEROL RATIO;
   EARLY-LIFE EXPOSURE; PERFLUOROALKYL SUBSTANCES; PERFLUORINATED
   COMPOUNDS; METABOLIC SYNDROME; BLOOD-PRESSURE; INSULIN-RESISTANCE;
   PRENATAL EXPOSURE; OXIDATIVE STRESS
AB Background: Per- and polyfluoroalkyl substances (PFAS) may adversely influence cardiometabolic risk. However, few studies have examined if the timing of early life PFAS exposure modifies their relation to cardiometabolic risk. We examined the influence of gestational and childhood PFAS exposure on adolescents' cardiometabolic risk.
   Methods: We quantified concentrations of four PFAS (perfluorooctanoate [PFOA], perfluorooctane sulfonate [PFOS], perfluorononanoate [PFNA], and perfluorohexane sulfonate [PFHxS]) in sera collected during pregnancy, at birth, and at ages 3, 8, and 12 years from 221 mother-child pairs in the HOME Study (enrolled 2003-06, Cincinnati, Ohio). We measured cardiometabolic risk factors using physical examinations, fasting serum biomarkers, and dual-energy X-ray absorptiometry scans at age 12 years. Cardiometabolic risk summary scores were calculated by summing ageand sex-standardized z-scores for individual cardiometabolic risk factors. We used multiple informant models to estimate covariate-adjusted associations of serum PFAS concentrations (log2-transformed) at each visit with cardiometabolic risk scores and their individual components, and tested for differences in associations across visits.
   Results: The associations of serum PFOA concentrations with cardiometabolic risk scores differed across visits (P for heterogeneity = 0.03). Gestational and cord serum PFOA concentrations were positively associated with cardiometabolic risk scores (beta s and 95% confidence intervals [95% CIs]: gestational 0.8 [0.0, 1.6]; cord 0.9 [-0.1, 1.9] per interquartile range increase). These positive associations were primarily driven by homeostatic model assessment for insulin resistance index (beta = 0.3 [0.1, 0.5]) and adiponectin to leptin ratio (beta = -0.5 [-1.0, 0.0]). Other individual cardiometabolic risk factors associated with gestational PFOA included insulin and waist circumference. Gestational and cord PFHxS were also associated with higher cardiometabolic risk scores (beta s: gestational 0.9 [0.2, 1.6]; cord 0.9 [0.1, 1.7]).
   Conclusion: In this cohort of children with higher gestational PFOA exposure, fetal exposure to PFOA and PFHxS was associated with unfavorable cardiometabolic risk in adolescence.
C1 [Li, Nan; Liu, Yun; Eaton, Charles B.; Kelsey, Karl T.; Braun, Joseph M.] Brown Univ, Sch Publ Hlth, Dept Epidemiol, Providence, RI 02912 USA.
   [Papandonatos, George D.] Brown Univ, Sch Publ Hlth, Dept Biostat, Providence, RI 02912 USA.
   [Calafat, Antonia M.] Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Atlanta, GA USA.
   [Eaton, Charles B.] Brown Univ, Dept Family Med, Warren Alpert Med Sch, Providence, RI 02912 USA.
   [Eaton, Charles B.] Kent Mem Hosp, Warwick, RI USA.
   [Kelsey, Karl T.] Brown Univ, Dept Pathol & Lab Med, Providence, RI 02912 USA.
   [Cecil, Kim M.; Kalkwarf, Heidi J.; Yolton, Kimberly] Univ Cincinnati, Coll Med, Dept Pediat, Cincinnati, OH USA.
   [Cecil, Kim M.] Univ Cincinnati, Cincinnati Childrens Hosp Med Ctr, Dept Radiol, Coll Med, Cincinnati, OH USA.
   [Kalkwarf, Heidi J.] Cincinnati Childrens Hosp Med Ctr, Dept Pediat, Div Gastroenterol Hepatol & Nutr, Cincinnati, OH USA.
   [Yolton, Kimberly] Univ Cincinnati, Cincinnati Childrens Hosp Med Ctr, Dept Pediat, Div Gen & Community Pediat,Coll Med, Cincinnati, OH USA.
   [Lanphear, Bruce P.] Simon Fraser Univ, Fac Hlth Sci, Burnaby, BC, Canada.
   [Chen, Aimin] Univ Penn, Perelman Sch Med, Dept Biostat Epidemiol & Informat, Philadelphia, PA 19104 USA.
C3 Brown University; Brown University; Centers for Disease Control &
   Prevention - USA; Brown University; Brown University; University System
   of Ohio; University of Cincinnati; University System of Ohio; University
   of Cincinnati; Cincinnati Children's Hospital Medical Center; Cincinnati
   Children's Hospital Medical Center; University System of Ohio;
   University of Cincinnati; Cincinnati Children's Hospital Medical Center;
   Simon Fraser University; University of Pennsylvania
RP Li, N (corresponding author), Brown Univ, Box G-S121-2, Providence, RI 02912 USA.
EM nan_li1@brown.edu; yun_liu@brown.edu; gdp@stat.brown.edu; aic7@cdc.gov;
   charles_eaton@brown.edu; karl_kelsey@brown.edu; Kim.Cecil@cchmc.org;
   heidi.kalkwarf@cchmc.org; kimberly.yolton@cchmc.org; bpl3@sfu.ca;
   aimin.chen@pennmedicine.upenn.edu; joseph_braun_1@brown.edu
RI Kelsey, Karl/I-1252-2014; Li, Nan/R-6280-2017; Calafat,
   Antonia/GOP-1115-2022; Yunkunis, Kimberly/AAO-5605-2021; Papandonatos,
   George/J-2328-2014
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NR 147
TC 40
Z9 40
U1 5
U2 37
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0160-4120
EI 1873-6750
J9 ENVIRON INT
JI Environ. Int.
PD FEB
PY 2021
VL 147
AR 106344
DI 10.1016/j.envint.2020.106344
EA JAN 2021
PG 14
WC Environmental Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology
GA QA5VT
UT WOS:000613514200015
PM 33418195
OA gold, Green Accepted
DA 2025-06-11
ER

PT J
AU Sánchez, MLC
   Spalm, FHP
   Furland, NE
   Vallés, AS
AF Sanchez, Marie L. Cuervo
   Spalm, Facundo H. Prado
   Furland, Natalia E.
   Valles, Ana S.
TI Pregestational fructose-induced metabolic syndrome in Wistar rats causes
   sexually dimorphic behavioral changes in their offspring
SO DEVELOPMENTAL NEUROBIOLOGY
LA English
DT Article
DE high-fructose diet; maternal metabolic syndrome; neurobehavior;
   offspring
ID ELEVATED PLUS-MAZE; INSULIN-RESISTANCE SYNDROME; ANXIETY-LIKE BEHAVIOR;
   INFLAMMATION; HIPPOCAMPUS; SEROTONIN; DIET; STRESS; MODELS; IMPACT
AB Metabolic syndrome (MetS), marked by enduring metabolic inflammation, has detrimental effects on cognitive performance and brain structure, influencing behavior. This study aimed to investigate whether maternal MetS could negatively impact the neurodevelopment and metabolism of offspring. To test this hypothesis, 2 months old female Wistar rats were subjected to a 10-week regimen of tap water alone or supplemented with 20% fructose to induce MetS. Dams were mated with healthy males to generate litters: OC (offspring from control dams) and OMetS (offspring from dams with MetS). To isolate prenatal effects, all pups were breastfed by control nurse dams, maintaining a standard diet and water ad libitum until weaning. Behavioral assessments were conducted between postnatal days (PN) 22 and 95, and metabolic parameters were analyzed post-sacrifice on PN100. Results from the elevated plus maze, the open field, and the marble burying tests revealed a heightened anxiety-like phenotype in OMetS females. The novel object recognition test showed that exclusively OMetS males had long-term memory impairment. In the reciprocal social interaction test, OMetS displayed a lower number of social interactions, with a notable increase in "socially inactive" behavior observed exclusively in females. Additionally, in the three-chamber test, social preference and social novelty indexes were found to be lower solely among OMetS females. An increase in visceral fat concomitantly with hypertriglyceridemia was the relevant postmortem metabolic finding in OMetS females. In summary, maternal MetS leads to enduring damage and adverse effects on offspring neurobehavior and metabolism, with notable sexual dimorphism.
C1 [Sanchez, Marie L. Cuervo; Spalm, Facundo H. Prado; Furland, Natalia E.; Valles, Ana S.] INIBIBB CONICET UNS, Nutr & Neurodev Lab, Camino Carrindanga Km 7, RA-B8000FWB Bahia Blanca, Argentina.
RP Vallés, AS (corresponding author), INIBIBB CONICET UNS, Nutr & Neurodev Lab, Camino Carrindanga Km 7, RA-B8000FWB Bahia Blanca, Argentina.
EM sofiavalles@gmail.com
RI Vallés, Ana/GVU-5374-2022
FU ANPCyT (Agencia Nacional de Promocin de la Ciencia y la Tecnologa
FX We would like to thank Weiner lab, Argentina for providing the enzymatic
   commercial kits used in this work.
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NR 60
TC 0
Z9 0
U1 0
U2 0
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1932-8451
EI 1932-846X
J9 DEV NEUROBIOL
JI Dev. Neurobiol.
PD JUL
PY 2024
VL 84
IS 3
BP 142
EP 157
DI 10.1002/dneu.22940
EA APR 2024
PG 16
WC Developmental Biology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Developmental Biology; Neurosciences & Neurology
GA ZC7N1
UT WOS:001208120600001
PM 38664979
DA 2025-06-11
ER

PT J
AU Mishra, KK
   Sawant, N
   Garg, S
AF Mishra, Kshirod Kumar
   Sawant, Neena
   Garg, Shobit
TI Management of Psychiatric Disorders in Patients with Endocrine Disorders
SO INDIAN JOURNAL OF PSYCHIATRY
LA English
DT Article
DE Diabetes; endocrine; metabolic syndrome; thyroid
ID DIABETES-MELLITUS; GLYCEMIC CONTROL; DEPRESSION; TYPE-1; ADULTS;
   DYSFUNCTION; PREVALENCE; PROLACTIN; HYPERPROLACTINEMIA; PATHOPHYSIOLOGY
AB The neuropsychiatric symptoms and disorders among endocrine disorders are discussed in the context of current global and local epidemiological data. Neuropsychiatric symptoms, clinical differentials in hypothyroidism, hyperthyroidism, and parathyroid disorders, and relevant management protocols are described. HPT axis and its interaction with psychotropic usage are mentioned. Stress diathesis, depression, anxiety disorders, and severe mental illnesses and their respective association with diabetes, the relevant mechanisms, and management protocols are stated. The metabolic syndrome, its definition, and its relationship to psychotropic usage are laid out. Moreso, best clinical practices for scenarios such as hyperprolactinemia and psychiatric illnesses, and steroid-induced psychosis are mentioned.
C1 [Mishra, Kshirod Kumar] Mahatma Gandhi Inst Med Sci, Dept Psychiat, Sevagram, Maharashtra, India.
   [Sawant, Neena] Seth GSMC & KEM Hosp, Dept Psychiat, Mumbai, Maharashtra, India.
   [Garg, Shobit] Shri Guru Ram Rai Inst Med & Hlth Sci, Dept Psychiat, Dehra Dun, Uttarakhand, India.
C3 Mahatma Gandhi Institute of Medical Sciences, Sevagram; Seth Gordhandas
   Sunderdas Medical College & King Edward Memorial Hospital
RP Mishra, KK (corresponding author), Mahatma Gandhi Inst Med Sci, Dept Psychiat, Sevagram, Maharashtra, India.
EM kmishra@mgims.ac.in
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NR 50
TC 7
Z9 7
U1 1
U2 5
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, Maharashtra, INDIA
SN 0019-5545
EI 1998-3794
J9 INDIAN J PSYCHIAT
JI Indian J. Psychiatry
PD MAR
PY 2022
VL 64
SU 2
BP S402
EP S413
DI 10.4103/indianjpsychiatry.indianjpsychiatry_30_22
PG 12
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 0N8IH
UT WOS:000783075000019
PM 35602375
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Murphy, KA
   Daumit, GL
AF Murphy, Karly A.
   Daumit, Gail L.
TI Establishing a Care Continuum for Cardiometabolic Conditions for
   Patients with Serious Mental Illness
SO CURRENT CARDIOLOGY REPORTS
LA English
DT Review
DE Serious mental illness; Schizophrenia; Cardiovascular disease; Diabetes;
   Integrated care; Primary care
ID MEDICAL-CARE; CARDIOVASCULAR-DISEASE; COLLABORATIVE CARE; HEALTH
   CONDITIONS; DIABETES CARE; OLDER-ADULTS; SCHIZOPHRENIA; PEOPLE;
   INTERVENTION; INDIVIDUALS
AB Purpose of ReviewAddressing cardiometabolic risk factors in persons with serious mental illness requires early screening and proactive medical management in both medical and mental health settings.Recent FindingsCardiovascular disease remains the leading cause of death for persons with serious mental illness (SMI), such as schizophrenia or bipolar disorder, much of which is driven by a high prevalence of metabolic syndrome, diabetes, and tobacco use. We summarize barriers and recent approaches to screening and treatment for metabolic cardiovascular risk factors within physical health and specialty mental health settings.Incorporating system-based and provider-level support within physical health and psychiatric clinical settings should contribute to improvement for screening, diagnosis, and treatment for cardiometabolic conditions for patients with SMI. Targeted education for clinicians and leveraging multi-disciplinary teams are important first steps to recognize and treat populations with SMI at risk of CVD.
C1 [Murphy, Karly A.] Univ Calif San Francisco, Div Gen Internal Med, Sch Med, 1701 Divisidero St,Suite 500, San Francisco, CA 94117 USA.
   [Daumit, Gail L.] Johns Hopkins Sch Med, Div Gen Internal Med, Baltimore, MD USA.
C3 University of California System; University of California San Francisco;
   Johns Hopkins University; Johns Hopkins Medicine
RP Murphy, KA (corresponding author), Univ Calif San Francisco, Div Gen Internal Med, Sch Med, 1701 Divisidero St,Suite 500, San Francisco, CA 94117 USA.
EM karly.murphy@ucsf.edu; gdaumit@jhmi.edu
OI Murphy, Karly/0000-0001-5576-8859
FU NIMH [P50 MH115842]; NHLBI [UG3154280]
FX Gail L. Daumit reports grants from NIMH (P50 MH115842) and NHLBI
   (UG3154280).
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NR 100
TC 2
Z9 2
U1 0
U2 4
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1523-3782
EI 1534-3170
J9 CURR CARDIOL REP
JI Curr. Cardiol. Rep.
PD APR
PY 2023
VL 25
IS 4
BP 193
EP 202
DI 10.1007/s11886-023-01848-z
EA FEB 2023
PG 10
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA AF1W1
UT WOS:000940184600001
PM 36847991
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Romba, C
   Perez-Reisler, M
AF Romba, Courtney
   Perez-Reisler, Marisa
TI Management of Adverse Effects of Psychotropic Medications
SO PEDIATRIC ANNALS
LA English
DT Article
ID METAANALYSIS; OVERWEIGHT; METFORMIN; RISK
AB Psychotropic medications are an essential component of treating pediatric mental health disorders, and pediatricians are increasingly likely to prescribe them. Commonly used psychotropic medications include stimulants and nonstimulants used in the treatment of attention-deficit/hyperactivity disorder (ADHD); antidepressants used in the treatment of anxiety and depression; and antipsychotics indicated for use in autism, schizophrenia, mood disorders, severe impulsivity, and aggression. Stimulants are commonly associated with appetite suppression and initial insomnia and nonstimulants for ADHD are associated with sedation. Antidepressants are generally well tolerated; adverse effects include behavioral activation early in treatment and, rarely, treatment-emergent mania and suicidal ideation. Potential adverse effects of atypical antipsychotics include weight gain and metabolic syndrome. Monitoring strategies are reviewed.
C1 [Romba, Courtney; Perez-Reisler, Marisa] Ann & Robert H Lurie Childrens Hosp Chicago, Pritzker Dept Psychiat & Behav Hlth, Chicago, IL 60611 USA.
   [Romba, Courtney; Perez-Reisler, Marisa] Northwestern Univ, Feinberg Sch Med, Evanston, IL 60208 USA.
C3 Ann & Robert H. Lurie Children's Hospital of Chicago; Northwestern
   University; Feinberg School of Medicine
RP Romba, C (corresponding author), Ann & Robert H Lurie Childrens Hosp Chicago, 225 E Chicago Ave,Box 10, Chicago, IL 60611 USA.
EM cromba@luriechildrens.org
CR [Anonymous], 2004, J CLIN PSYCHIAT, V65, P267
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NR 14
TC 2
Z9 3
U1 0
U2 5
PU SLACK INC
PI THOROFARE
PA 6900 GROVE RD, THOROFARE, NJ 08086 USA
SN 0090-4481
EI 1938-2359
J9 PEDIATR ANN
JI Pediatr. Ann.
PD OCT
PY 2020
VL 49
IS 10
BP E431
EP E435
DI 10.3928/19382359-20200922-03
PG 5
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Pediatrics
GA PE2CW
UT WOS:000598178200007
PM 33034658
DA 2025-06-11
ER

PT J
AU Balakrishnan, G
   Iqbal, T
   Uppinakudru, G
   Fernandes, R
   Bangera, S
   Dutt, RA
AF Balakrishnan, Grrishma
   Iqbal, Tubah
   Uppinakudru, Gurunandan
   Fernandes, Ryan
   Bangera, Shobith
   Dutt, R. Aswini
TI The impact of lifestyle stressors, menstrual pattern, and
   cardiometabolic risk factors on young females with cholelithiasis
SO JOURNAL OF EDUCATION AND HEALTH PROMOTION
LA English
DT Article
DE Cholelithiasis; gallstones; lifestyle; metabolic syndrome
ID METABOLIC SYNDROME; CARDIOVASCULAR-DISEASE; GALLSTONE DISEASE;
   PATHOGENESIS; EPIDEMIOLOGY; PREVALENCE; OBESITY
AB BACKGROUND: Lifestyle and nutritional transitions in the society driven by globalization have led to the rising burden of cholelithiasis. The present study was done to assess the impact of lifestyle, stress, menstrual pattern, and cardiometabolic risk factors on young females with cholelithiasis. MATERIALS AND METHODS: A hospital-based case-control study was conducted on young females of 18-45 years. Cases and age-matched controls were compared on their lifestyle parameters like demography, marital status, occupation, educational status, family income, stress along with menstrual pattern, cardiometabolic parameters like anthropometric measures, blood pressure (BP), fasting blood sugar (FBS), and lipid profile. Chi-square test and unpaired t-test were used for the analysis of data using SPSS software, and P < 0.05 was considered statistically significant. RESULTS: The majority of the cases were from rural areas, married, homemakers leading a comparatively sedentary lifestyle consuming more red meat, less literate, and belonged to a lower economic group with significantly more stress compared to controls. The age of menarche, neither the regularity nor irregularity of the menstrual cycle (regular cycle 21-35 days), showed any difference, but cases had significantly more pregnancies and usage of oral contraceptives compared to controls. Waist-height ratio, systolic BP, FBS, triglyceride, low-density lipoprotein (LDL), and very low-density lipoprotein (VLDL) were significantly higher in cases. Cases had a 14.4 times more risk of developing metabolic syndrome when compared with controls. CONCLUSION: Married, rural, less literate Indian women leading a sedentary lifestyle, consuming more of red meat, and soft drinks with increased psychosomatic stress are more prone to develop cholelithiasis. Women who use hormonal contraceptives have increased occurrence of cholelithiasis and they were more prone to develop metabolic syndrome. The need for the hour is health education, to implement simple lifestyle changes, thereby decreasing the incidence of cholelithiasis in young females.
C1 [Balakrishnan, Grrishma; Bangera, Shobith; Dutt, R. Aswini] Deemed Univ, Yenepoya Med Coll, Dept Physiol, Mangalore, Karnataka, India.
   [Iqbal, Tubah] Koosamma Shambhu Shetty Mem Haji Abdulla Mother &, Dept Pediat, Udupi, Karnataka, India.
   [Uppinakudru, Gurunandan] Deemed Univ, Yenepoya Med Coll Hosp, Dept Cardiothorac & Vasc Surg, Mangalore, Karnataka, India.
   [Fernandes, Ryan] AJ Inst Med Sci, Dept Gen Surg, Mangalore, Karnataka, India.
   [Balakrishnan, Grrishma] Deemed Univ, Yenepoya Med Coll, Dept Physiol, Mangalore 575018, Karnataka, India.
C3 Yenepoya (Deemed to be University); Yenepoya (Deemed to be University);
   Yenepoya (Deemed to be University)
RP Balakrishnan, G (corresponding author), Deemed Univ, Yenepoya Med Coll, Dept Physiol, Mangalore 575018, Karnataka, India.
EM dr.grrishma@yenepoya.edu.in
RI Balakrishnan, Grrishma/GVT-0856-2022; R, Aswini/G-1203-2015
FU Indian Council of Medical Research under the Short-Term Studentship
   Program [2017-04178]; Vinnova [2017-04178] Funding Source: Vinnova
FX This project was funded by the Indian Council of Medical Research under
   the Short-Term Studentship Program (Reference ID: 2017-04178).
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NR 40
TC 0
Z9 0
U1 0
U2 2
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, Maharashtra, INDIA
SN 2277-9531
EI 2319-6440
J9 J EDUC HEALTH PROMOT
JI J. Educ. Health Promot.
PD JAN-DEC
PY 2022
VL 11
IS 1
DI 10.4103/jehp.jehp_1767_21
PG 8
WC Education, Scientific Disciplines; Public, Environmental & Occupational
   Health
WE Emerging Sources Citation Index (ESCI)
SC Education & Educational Research; Public, Environmental & Occupational
   Health
GA 5W4PQ
UT WOS:000877898400008
PM 36325235
OA Green Published
DA 2025-06-11
ER

PT J
AU Kim, SR
   Kim, H
   Song, SW
AF Kim, Se-Rae
   Kim, Ha-Na
   Song, Sang-Wook
TI Associations Between Mental Health, Quality of Life, and
   Obesity/Metabolic Risk Phenotypes
SO METABOLIC SYNDROME AND RELATED DISORDERS
LA English
DT Article
DE obesity; metabolic syndrome; mental health; quality of life
ID METABOLIC SYNDROME; OBESITY; MANAGEMENT; OVERWEIGHT
AB Background: Obesity is a risk factor for many health issues, as are metabolic abnormalities; all may affect mental health and one's health-related quality of life. Therefore, we investigated the association between obesity subtypes, considering both body weight and metabolic abnormalities, and the mental health and quality of life of a Korean population.
   Methods: We used data from the 2016 Korean National Health and Nutrition Examination Survey, a cross-sectional survey of Korean civilians, and data on a total of 6057 participants were analyzed. Obesity subtypes were classified as metabolically healthy but obese (MHO); metabolically abnormal but of normal weight (MANW); and metabolically abnormal and obese (MAO).
   Results: MHO was positively associated with mobility problems, pain/discomfort, and stress compared with metabolically healthy and of normal weight (MHNW) control. MAO was positively associated with problems in terms of not only mobility problems, pain/discomfort, and stress but also self-care and usual activity problems, and improper sleep duration, compared with the MHNW control. MANW showed no associations with the mental health problems or quality of life.
   Conclusions: With or without metabolic abnormalities, obesity is associated with mental health problems and decreased quality of life.
C1 [Kim, Se-Rae; Kim, Ha-Na; Song, Sang-Wook] Catholic Univ Korea, St Vincents Hosp, Coll Med, Dept Family Med, Seoul, South Korea.
C3 Catholic University of Korea
RP Song, SW (corresponding author), Catholic Univ Korea, St Vincents Hosp, Dept Family Med, Coll Med, Jungbu Daero 93, Suwon 16247, Gyeonggi Do, South Korea.
EM sswkoj@unitel.co.kr
FU Department of Biostatistics of the Catholic Research Coordinating Center
FX Statistical consultation was supported by the Department of
   Biostatistics of the Catholic Research Coordinating Center.
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NR 23
TC 17
Z9 18
U1 4
U2 28
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-4196
EI 1557-8518
J9 METAB SYNDR RELAT D
JI Metab. Syndr. Relat. Disord.
PD SEP 1
PY 2020
VL 18
IS 7
BP 347
EP 352
DI 10.1089/met.2020.0028
EA MAY 2020
PG 6
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Research & Experimental Medicine
GA NO2MD
UT WOS:000535515700001
PM 32429802
OA Bronze
DA 2025-06-11
ER

PT J
AU Mendham, AE
   Goedecke, JH
   Fortuin-de Smidt, MC
   Phiri, L
   Clamp, L
   Swart, J
   Lipinska, G
   Rae, DE
AF Mendham, Amy E.
   Goedecke, Julia H.
   Fortuin-de Smidt, Melony C.
   Phiri, Lindokuhle
   Clamp, Louise
   Swart, Jeroen
   Lipinska, Gosia
   Rae, Dale E.
TI Improved Sleep Quality and Depressive Symptoms With Exercise Training in
   Obese Women From a Low Socioeconomic Community: A Randomized Controlled
   Trial
SO JOURNAL OF PHYSICAL ACTIVITY & HEALTH
LA English
DT Article
DE mental health; cardiometabolic risk; cardiorespiratory fitness;
   sedentary behavior
ID PHYSICAL-ACTIVITY; INSULIN-RESISTANCE; DURATION; ANXIETY; HEALTH;
   ASSOCIATIONS; DISPARITY; INSOMNIA; COHORT; RISK
AB Background: Improving sleep quality and reducing depressive symptoms may be target mechanisms for intervention-based research aimed at reducing cardiometabolic risk in low-income communities. This study assessed the effects of exercise training on depressive symptoms and sleep in obese women for a low socioeconomic community. The secondary aim explored associations between changes in depressive symptoms and sleep with changes in cardiorespiratory fitness and cardiometabolic risk factors. Methods: Participants were randomized into exercise (n = 20) or control (n = 15) groups. The exercise group completed 12 weeks of combined resistance and aerobic training (40-60 min, 4 d/wk), and the control group maintained habitual diet and activity. Preintervention and postintervention testing included questionnaires on symptoms of depression, psychological distress, and sleep quality. Sedentary time, peak oxygen consumption, body mass index, and insulin sensitivity were measured objectively. Sleep duration (accelerometry) was assessed at preintervention and weeks 4, 8, and 12. Results: Exercise training reduced depressive symptoms (P= .002) and improved sleep quality (P < .001) and sleep efficiency (P = .005). Reduced depressive symptoms were associated with improved peak oxygen consumption (rho = -.600, P<.001), and improved sleep quality correlated with reduced sedentary time (rho = .415, P=.018). Conclusion: These results highlight the potential for community-based exercise interventions to simultaneously address multiple comorbidities in a low-income setting.
C1 [Mendham, Amy E.; Goedecke, Julia H.; Fortuin-de Smidt, Melony C.; Phiri, Lindokuhle; Clamp, Louise; Swart, Jeroen; Rae, Dale E.] Univ Cape Town, Fac Hlth Sci, Hlth Phys Act & Lifestyle Res Ctr, Dept Human Biol,Div Exercise Sci & Sports Med, Cape Town, South Africa.
   [Mendham, Amy E.] Univ Witwatersrand, Fac Hlth Sci, MRC Wits Dev Pathways Hlth Res Unit, Johannesburg, South Africa.
   [Fortuin-de Smidt, Melony C.] South African Med Res Council, Noncommunicable Dis Res Unit, Cape Town, South Africa.
   [Lipinska, Gosia] Univ Cape Town, Fac Humanities, Dept Psychol, Cape Town, South Africa.
C3 University of Cape Town; University of Witwatersrand; South African
   Medical Research Council; University of Cape Town
RP Mendham, AE (corresponding author), Univ Cape Town, Fac Hlth Sci, Hlth Phys Act & Lifestyle Res Ctr, Dept Human Biol,Div Exercise Sci & Sports Med, Cape Town, South Africa.; Mendham, AE (corresponding author), Univ Witwatersrand, Fac Hlth Sci, MRC Wits Dev Pathways Hlth Res Unit, Johannesburg, South Africa.
EM ae.mendham@uct.ac.za
RI Fortuin-de Smidt, Melony/GPX-1572-2022; Rae, Dale/JAC-7553-2023; Clamp,
   Louise/AAD-8909-2020; Lipinska, Gosia/JVY-8736-2024; Rae,
   Dale/W-1039-2017; Mendham, Amy E/AFI-8524-2022; Goedecke,
   Julia/J-8628-2013
OI Rae, Dale/0000-0002-2584-6585; Mendham, Amy E/0000-0002-1959-6698;
   Goedecke, Julia/0000-0001-6795-4771; Phiri,
   Lindokuhle/0000-0002-7666-4167; Clamp, Louise/0000-0001-5865-0944;
   Swart, Jeroen/0000-0001-7098-0313; Lipinska, Gosia/0000-0002-5025-3757
FU National Research Foundation of South Africa (NRF), Competitive
   Programme for Rated Researchers [93577]; South African Medical Research
   Council
FX The authors thank all participants for their involvement in the study.
   The authors would also like to thank their research assistants, Nandipha
   Sinyanya, Ntombekhaya Zoneleni, Keitumetse Smouse, and Hendriena Victor,
   for their valuable contribution during the data collection phase.
   Running costs and student bursaries for this study were funded by the
   National Research Foundation of South Africa (NRF), Competitive
   Programme for Rated Researchers (grant no. 93577), and the South African
   Medical Research Council. This trial was registered at the Pan African
   Clinical Trial Registry (no. 201711002789113).
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NR 52
TC 10
Z9 10
U1 2
U2 25
PU HUMAN KINETICS PUBL INC
PI CHAMPAIGN
PA 1607 N MARKET ST, PO BOX 5076, CHAMPAIGN, IL 61820-2200 USA
SN 1543-3080
EI 1543-5474
J9 J PHYS ACT HEALTH
JI J. Phys. Act. Health
PD APR
PY 2021
VL 18
IS 4
BP 440
EP 449
DI 10.1123/jpah.2020-0648
PG 10
WC Public, Environmental & Occupational Health
WE Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA RI3IF
UT WOS:000636800500014
PM 33714191
DA 2025-06-11
ER

PT J
AU Bhagya, K
   Fikri, A
   Elvandari, M
AF Bhagya, Kalani
   Fikri, Al Mukhlas
   Elvandari, Milliyantri
TI Differences in Risk Factors for Metabolic Syndrome and Stress Levels
   between School Teachers Living in Rural and Urban Areas in Karawang,
   Indonesia during the COVID- 19 Pandemic
SO JURNAL GIZI DAN PANGAN
LA English
DT Article
DE COVID-19 pandemic; metabolic syndrome; mental stress; risk factors
AB This study investigated the differences in metabolic syndrome risk factors and psychological stress levels among school teachers in rural and urban areas during the COVID-19 pandemic in Indonesia. Waist circumference, High-Density Lipoprotein (HDL) and triglyceride levels, hypertension status, and fasting blood glucose were measured in 71 participants. The results showed higher rates of large waist circumference and hypertension in rural areas, and higher rates of low HDL, high triglyceride, and high fasting blood glucose in urban areas. In addition, a greater percentage of individuals in both rural and urban areas experienced high level of stress. These findings suggest different health risks associated with living in different areas during the pandemic.
C1 [Bhagya, Kalani; Fikri, Al Mukhlas; Elvandari, Milliyantri] Univ Singaperbangsa Karawang, Fac Nutr, Dept Hlth Sci, Karawang 41361, Indonesia.
RP Fikri, A (corresponding author), Univ Singaperbangsa Karawang, Fac Nutr, Dept Hlth Sci, Karawang 41361, Indonesia.
EM mukhlas.fikri@fikes.unsika.ac.id
CR Cyr ME, 2019, BMC HEALTH SERV RES, V19, DOI 10.1186/s12913-019-4815-5
   Gassasse Z, 2017, BMJ GLOB HEALTH, V2, DOI 10.1136/bmjgh-2017-000473
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NR 5
TC 0
Z9 0
U1 1
U2 1
PU BOGOR AGRICULTURAL UNIV, DEPT COMMUNITY NUTRITION, FAC HUMAN ECOLOGY
PI JAWA BARAT
PA KAMPUS IPB DARMAGA, JL RAYA DARMAGA, BOGOR, JAWA BARAT, 16680, INDONESIA
SN 1978-1059
EI 2407-0920
J9 J GIZI PANGAN
JI J. Gizi Pangan
PD FEB
PY 2023
VL 18
SU 1
BP 131
EP 133
PG 3
WC Nutrition & Dietetics
WE Emerging Sources Citation Index (ESCI)
SC Nutrition & Dietetics
GA EE2L5
UT WOS:001137176300025
DA 2025-06-11
ER

PT J
AU Maouche, N
   Meskine, D
   Alamir, B
   Koceir, EA
AF Maouche, Naima
   Meskine, Djamila
   Alamir, Barkahoum
   Koceir, Elhadj-Ahmed
TI Trace elements profile is associated with insulin resistance syndrome
   and oxidative damage in thyroid disorders: Manganese and selenium
   interest in Algerian participants with dysthyroidism
SO JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
LA English
DT Article
DE Dysthyroidism; Manganese; Selenium; Oxidative stress; Insulin Resistance
   Syndrome
ID HOMEOSTASIS MODEL ASSESSMENT; SERUM FERRITIN; IRON; HORMONE; BINDING;
   HYPERTHYROIDISM; TRANSPORT; STRESS; TRANSFERRIN; ACTIVATION
C1 [Maouche, Naima; Koceir, Elhadj-Ahmed] USTHB, Fac Biol Sci, Bioenerget & Intermediary Metab Team, Biol & Organisms Physiol Lab, Algiers 16123, Algeria.
   [Maouche, Naima; Meskine, Djamila] Ibnou Ziri Bologhine Univ Hosp Ctr, Dept Endocrinol, Endocrinol Explorat Unit, Algiers 16090, Algeria.
   [Alamir, Barkahoum] Bab El Oued Univ Hosp Ctr, Natl Toxicol Ctr, Algiers 16009, Algeria.
C3 University Science & Technology Houari Boumediene
RP Koceir, EA (corresponding author), USTHB, Fac Biol Sci, Bioenerget & Intermediary Metab Team, Biol & Organisms Physiol Lab, Algiers 16123, Algeria.
EM naimamaouche@yahoo.fr; djamila.mes@voila.fr; alamir.b@hotmail.com;
   e.koceir@gmail.com
OI KOCEIR, Elhadj-Ahmed/0000-0003-1345-2535
FU Algerian Thematic Research in Health Sciences Agency (ATRSS); General
   Division for Scientific Research Technological Development (DG- RSDT)
FX The research was supported by the Algerian Thematic Research in Health
   Sciences Agency (ATRSS) and the General Division for Scientific Research
   Technological Development (DG- RSDT).
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NR 70
TC 18
Z9 19
U1 0
U2 9
PU ELSEVIER GMBH
PI MUNICH
PA HACKERBRUCKE 6, 80335 MUNICH, GERMANY
SN 0946-672X
J9 J TRACE ELEM MED BIO
JI J. Trace Elem. Med. Biol.
PY 2015
VL 32
BP 112
EP 121
DI 10.1016/j.jtemb.2015.07.002
PG 10
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA CS9AC
UT WOS:000362380200015
PM 26302919
DA 2025-06-11
ER

PT J
AU Farr, OM
   Ko, BJ
   Joung, KE
   Zaichenko, L
   Usher, N
   Tsoukas, M
   Thakkar, B
   Davis, CR
   Crowell, JA
   Mantzoros, CS
AF Farr, O. M.
   Ko, B. -J.
   Joung, K. E.
   Zaichenko, L.
   Usher, N.
   Tsoukas, M.
   Thakkar, B.
   Davis, C. R.
   Crowell, J. A.
   Mantzoros, C. S.
TI Posttraumatic stress disorder, alone or additively with early life
   adversity, is associated with obesity and cardiometabolic risk
SO NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
LA English
DT Article
DE PTSD; Adversity; Obesity; Cardiac risk
ID METABOLIC SYNDROME; PTSD; COMORBIDITY; DEPRESSION; BIOMARKERS;
   INTERVIEW; MIDLIFE
AB Background and aims: There is some evidence that posttraumatic stress disorder ( PTSD) and early life adversity may influence metabolic outcomes such as obesity, diabetes, and cardiovascular disease. However, whether and how these interact is not clear.
   Methods: We analyzed data from a cross-sectional and longitudinal study to determine how PTSD severity influences obesity, insulin sensitivity, and key measures and biomarkers of cardiovascular risk. We then looked at how PTSD and early life adversity may interact to impact these same outcomes.
   Results: PTSD severity is associated with increasing risk of obesity, diabetes, and cardiovascular disease, with higher symptoms correlating with higher values of BMI, leptin, fibrinogen, and blood pressure, and lower values of insulin sensitivity. PTSD and early life adversity have an additive effect on these metabolic outcomes. The longitudinal study confirmed findings from the cross sectional study and showed that fat mass, leptin, CRP, sICAM-1, and sTNFRII were significantly increased with higher PTSD severity during a 2.5 year follow-up period.
   Conclusions: Individuals with early life adversity and PTSD are at high risk and should be monitored carefully for obesity, insulin resistance, and cardiometabolic risk. (C) 2015 Elsevier B.V. All rights reserved.
C1 [Farr, O. M.; Zaichenko, L.; Tsoukas, M.; Thakkar, B.; Mantzoros, C. S.] Harvard Univ, Sch Med, VA Boston Healthcare Syst, Endocrinol Sect, Boston, MA USA.
   [Farr, O. M.; Ko, B. -J.; Joung, K. E.; Zaichenko, L.; Tsoukas, M.; Thakkar, B.; Mantzoros, C. S.] Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Div Endocrinol Diabet & Metab, Boston, MA 02215 USA.
   [Ko, B. -J.] Sungkyunkwan Univ, Sch Med, Kangbuk Samsung Hosp, Total Healthcare Ctr, Seoul, South Korea.
   [Joung, K. E.] Boston Childrens Hosp, Div Newborn Med, Boston, MA USA.
   [Usher, N.; Davis, C. R.; Crowell, J. A.] Judge Baker Childrens Ctr, Boston, MA 02120 USA.
   [Thakkar, B.] Boston Univ, Sch Med, Boston Med Ctr, Sect Endocrinol Diabet & Nutr, Boston, MA 02118 USA.
   [Crowell, J. A.] SUNY Stony Brook, Sch Med, Dept Psychiat, Stony Brook, NY 11794 USA.
C3 Harvard University; Harvard Medical School; Harvard University Medical
   Affiliates; US Department of Veterans Affairs; Veterans Health
   Administration (VHA); VA Boston Healthcare System; Harvard University;
   Harvard University Medical Affiliates; Beth Israel Deaconess Medical
   Center; Harvard Medical School; Sungkyunkwan University (SKKU); Samsung
   Medical Center; Harvard University; Harvard University Medical
   Affiliates; Boston Children's Hospital; Harvard University; Harvard
   University Medical Affiliates; Judge Baker's Children's Center; Boston
   University; Boston Medical Center; State University of New York (SUNY)
   System; Stony Brook University
RP Farr, OM (corresponding author), Beth Israel Deaconess Med Ctr, 330 Brookline Ave,Feldberg 868, Boston, MA 02215 USA.
EM ofarr@bidmc.harvard.edu
RI Farr, Olivia/H-6929-2019; Mantzoros, Christos/Y-2902-2019
OI Tsoukas, Michael/0000-0002-8326-7274; Joung, Kyoung
   Eun/0000-0002-5942-4241; Farr, Olivia/0000-0002-5182-3432; Zaichenko,
   Lesya/0000-0001-8489-3886
FU National Institute on Aging [R01-AG032030]; National Institute of
   Diabetes and Digestive and Kidney Diseases [DK81913]; Clinical Science
   Research and Development Service of the VA Office of Research and
   Development [1I01CX000422-01A1]; Harvard Clinical and Translational
   Science Center Grant from National Center for Research Resources [UL1
   RR025758]; NICHD [5T32HD052961]
FX This study was supported by the National Institute on Aging Grant
   R01-AG032030 and National Institute of Diabetes and Digestive and Kidney
   Diseases Grant DK81913 and Award 1I01CX000422-01A1 from the Clinical
   Science Research and Development Service of the VA Office of Research
   and Development. The project was also supported by Harvard Clinical and
   Translational Science Center Grant UL1 RR025758 from the National Center
   for Research Resources. Olivia M. Farr is supported by a training grant
   through the NICHD 5T32HD052961.
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NR 26
TC 65
Z9 72
U1 1
U2 30
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0939-4753
EI 1590-3729
J9 NUTR METAB CARDIOVAS
JI Nutr. Metab. Carbiovasc. Dis.
PD MAY
PY 2015
VL 25
IS 5
BP 479
EP 488
DI 10.1016/j.numecd.2015.01.007
PG 10
WC Cardiac & Cardiovascular Systems; Endocrinology & Metabolism; Nutrition
   & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Endocrinology & Metabolism;
   Nutrition & Dietetics
GA CG2RS
UT WOS:000353123000007
PM 25770759
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Poursafa, P
   Dadvand, P
   Amin, MM
   Hajizadeh, Y
   Ebrahimpour, K
   Mansourian, M
   Pourzamani, H
   Sunyer, J
   Kelishadi, R
AF Poursafa, Parinaz
   Dadvand, Payam
   Amin, Mohammad Mehdi
   Hajizadeh, Yaghoub
   Ebrahimpour, Karim
   Mansourian, Marjan
   Pourzamani, Hamidreza
   Sunyer, Jordi
   Kelishadi, Roya
TI Association of polycyclic aromatic hydrocarbons with cardiometabolic
   risk factors and obesity in children
SO ENVIRONMENT INTERNATIONAL
LA English
DT Article
DE Polycyclic aromatic hydrocarbon; Cardiometabolic risk factor; Obesity;
   Children
ID NUTRITION EXAMINATION SURVEY; NORMAL-WEIGHT; METABOLIC SYNDROME;
   CHILDHOOD OBESITY; ENVIRONMENTAL EXPOSURES; CARDIOVASCULAR-DISEASE;
   INSULIN-RESISTANCE; OXIDATIVE STRESS; NATIONAL-HEALTH; BODY-FAT
AB A limited body of evidence exists on the association of exposure to polycyclic aromatic hydrocarbons (PAHs) with cardiometabolic risk factors and obesity in children. No study has evaluated these associations in subgroups of children with and without excess weight, and those with and without cardiometabolic risk factors. We aimed to investigate the association between PAH exposure and cardiometabolic risk factors in children independent of their weight status. The secondary aim was to evaluate the obesogen properties of PAHs in children independent of their cardiometabolic risk factors. This study was based on a representative sample of 186 children (aged 6-18 years) living in Isfahan, Iran (2014-2016). We enrolled four groups of participants with and without excess weight and with and without cardiometabolic risk factor. Urinary levels of monohydroxy PAHs (OH-PAHs) were measured twice, six months apart. Logistic regression models were developed to estimate the associations of tertiles of urinary OH-PAH concentrations with cardiometabolic risk factors and excess weight, adjusted for the relevant covariates. The findings in all participants combined showed that increased risk of cardiometabolic risk factors and excess weight was associated with exposure to most of evaluated PAHs. Exposure to 1-hydroxypyrene was associated with higher risk of cardiometabolic risk factors in participants with excess weight. Exposure to 2-Naphtol was also associated with higher risk of cardiometabolic risk factors in both groups, but the associations were not significant (p < 0.1). For participants without cardiometabolic risk factors, exposure to 2-naphtol, 9-phenanthrol, and Sigma OH-PAH was associated with increased risk of obesity. For participants with cardiometabolic risk factors, we observed similar pattern of associations for 2-naphtol and Sigma OH-PAH, but the associations were not statistically significant (p < 0.1). We found that exposure to PAHs could possibly explain, in part, the cardiometabolic risk factors in children with excess weight as well as obesity in children with normal cardiometabolic profile.
C1 [Poursafa, Parinaz; Amin, Mohammad Mehdi; Hajizadeh, Yaghoub; Ebrahimpour, Karim; Mansourian, Marjan; Pourzamani, Hamidreza] Isfahan Univ Med Sci, Environm Res Ctr, Res Inst Primordial Prevent Noncommunicable Dis, Esfahan, Iran.
   [Dadvand, Payam; Sunyer, Jordi] ISGlobal, Parc Recerca Biomed Barcelona,Doctor Aiguader 88, Barcelona 08003, Spain.
   [Dadvand, Payam; Sunyer, Jordi] Pompeu Fabra Univ, Barcelona, Spain.
   [Dadvand, Payam; Sunyer, Jordi] Ciber Epidemiol & Publ Hlth CIBERESP, Madrid, Spain.
   [Kelishadi, Roya] Isfahan Univ Med Sci, Res Inst Primordial Prevent Noncommunicable Dis, Child Growth & Dev Res Ctr, Hezarjerib Ave, Esfahan, Iran.
C3 Isfahan University of Medical Sciences; ISGlobal; Pompeu Fabra
   University; CIBER - Centro de Investigacion Biomedica en Red; CIBERESP;
   Isfahan University of Medical Sciences
RP Dadvand, P (corresponding author), ISGlobal, Parc Recerca Biomed Barcelona,Doctor Aiguader 88, Barcelona 08003, Spain.; Kelishadi, R (corresponding author), Isfahan Univ Med Sci, Res Inst Primordial Prevent Noncommunicable Dis, Child Growth & Dev Res Ctr, Hezarjerib Ave, Esfahan, Iran.
EM payam.dadvand@isglobal.org; kroya@aap.net
RI Hajizadeh, Yaghoub/A-1562-2018; pourzamani, Hamidreza/C-4787-2011;
   Ebrahimpour, Karim/A-4556-2018; Mansourian, Marjan/AAX-1011-2020;
   Kelishadi, Roya/E-6154-2012; poursafa, parinaz/U-2924-2017; Sunyer Deu,
   Jordi/G-6909-2014; amin, mohammadmehdi/A-1587-2018; Ebrahimpour,
   Karim/A-7180-2018; Dadvand, Payam/O-8053-2018
OI Sunyer Deu, Jordi/0000-0002-2602-4110; amin,
   mohammadmehdi/0000-0001-5758-7277; Pourzamani,
   Hamidreza/0000-0001-9509-1379; Ebrahimpour, Karim/0000-0002-6230-0119;
   Mansourian, Marjan/0000-0002-7217-0282; Dadvand,
   Payam/0000-0002-2325-1027
FU Iran's National Elites Foundation; Vice-chancellery for Research and
   Technology, Isfahan University of Medical Sciences, Isfahan, Iran
   [193042]; Ramon y Cajal fellowship - Spanish Ministry of Economy and
   Competitiveness [RYC-2012-10995]
FX This study was supported by Iran's National Elites Foundation and
   Vice-chancellery for Research and Technology, Isfahan University of
   Medical Sciences, Isfahan, Iran (Project No. 193042). Payam Dadvand is
   funded by a Ramon y Cajal fellowship (RYC-2012-10995) awarded by the
   Spanish Ministry of Economy and Competitiveness. The sponsor or funding
   organizations had no role in the design or conduct of this research.
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NR 70
TC 59
Z9 60
U1 2
U2 93
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0160-4120
EI 1873-6750
J9 ENVIRON INT
JI Environ. Int.
PD SEP
PY 2018
VL 118
BP 203
EP 210
DI 10.1016/j.envint.2018.05.048
PG 8
WC Environmental Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology
GA GM5MX
UT WOS:000438183000024
PM 29886236
DA 2025-06-11
ER

PT J
AU Garbarino, S
   Magnavita, N
AF Garbarino, Sergio
   Magnavita, Nicola
TI Obstructive Sleep Apnea Syndrome (OSAS), Metabolic Syndrome and Mental
   Health in Small Enterprise Workers. Feasibility of an Action for Health
SO PLOS ONE
LA English
DT Article
ID POSITIVE AIRWAY PRESSURE; ENDOTHELIAL FUNCTION; CARDIOVASCULAR RISK;
   ITALIAN VERSION; OBESITY; DEPRESSION; IMPAIRMENT; ANXIETY; SCALE;
   QUESTIONNAIRE
AB Objective: To determine the frequency of obstructive sleep apnea syndrome (OSAS), metabolic syndrome and common mental disorders in the working population of 11 small enterprises and the feasibility of a program of action for health.
   Method: The clinical risk of OSAS, the prevalence of metabolic syndrome, and the level of psychological disorders were assessed during routine medical examination at the workplace in 2012. The response to medical advice was assessed in 2013.
   Results: 12.3% of the workers were suspected of being affected by OSAS. One or more components of metabolic syndrome were present in 24.5% of cases. OSAS in "healthy" workers was significantly associated with the presence of one or more components of metabolic syndrome (OR = 3.83; 95% CI 1.45-10.13) and with a psychological disorders score in the highest quartile (OR = 4.67; 95% CI = 1.72-12.64). Workers with suspected OSAS were reluctant to follow advice about undergoing further tests under the NHS. However, in some cases, confirmation of the OSAS diagnosis and subsequent treatment led to an improvement in metabolic condition.
   Conclusion: Although participation in treatment was limited, anecdotal cases support the idea that prevention of obstructive sleep apnea in the workplace might be useful for workers' health.
C1 [Garbarino, Sergio] Univ Genoa, Dept Neurosci Rehabil Ophthalmol Genet & Maternal, Genoa, Italy.
   [Garbarino, Sergio] Univ Genoa, Dept Hlth Sci, Genoa, Italy.
   [Magnavita, Nicola] Univ Cattolica Sacro Cuore, Sect Occupat & Environm Med, Dept Publ Hlth, Rome, Italy.
C3 University of Genoa; University of Genoa; Catholic University of the
   Sacred Heart; IRCCS Policlinico Gemelli
RP Magnavita, N (corresponding author), Univ Cattolica Sacro Cuore, Sect Occupat & Environm Med, Dept Publ Hlth, Rome, Italy.
EM nicolamagnavita@gmail.com
RI Magnavita, Nicola/J-6074-2014; Garbarino, Sergio/X-5368-2018
OI Garbarino, Sergio/0000-0002-8508-552X
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NR 49
TC 22
Z9 24
U1 0
U2 5
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAY 8
PY 2014
VL 9
IS 5
AR e97188
DI 10.1371/journal.pone.0097188
PG 6
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA AK1XT
UT WOS:000338213300130
PM 24810290
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Gluba, A
   Mikhailidis, DP
   Lip, GYH
   Hannam, S
   Rysz, J
   Banach, M
AF Gluba, Anna
   Mikhailidis, Dimitri P.
   Lip, Gregory Y. H.
   Hannam, Simon
   Rysz, Jacek
   Banach, Maciej
TI Metabolic syndrome and renal disease
SO INTERNATIONAL JOURNAL OF CARDIOLOGY
LA English
DT Review
DE Dyslipidemia; Kidney disease; Kidney stones; Metabolic syndrome; Obesity
ID CHRONIC KIDNEY-DISEASE; ENDOPLASMIC-RETICULUM STRESS; INSULIN-RESISTANCE
   SYNDROME; UNFOLDED PROTEIN RESPONSE; RENIN-ANGIOTENSIN SYSTEM; EXTREMELY
   OBESE-PATIENTS; CORONARY-HEART-DISEASE; 3RD NATIONAL-HEALTH; C-REACTIVE
   PROTEIN; BLOOD-PRESSURE
AB The metabolic syndrome (MetS) is a cluster of risk factors including insulin resistance, dyslipidemia and hypertension which are also relevant for the development of chronic kidney disease (CKD). It has proven difficult to elucidate whether the renal dysfunction in MetS is due to the MetS itself or the individual risk factors. For example, obesity - which is also part of the MetS - may enhance the risk of renal dysfunction development probably through mechanisms associated with renal hyperfiltration, hyperperfusion and focal glomerulosclerosis. Insulin resistance also promotes kidney disease by worsening renal hemodynamics. In patients with MetS, tubular atrophy, interstitial fibrosis, and arteriolar sclerosis indicating the presence of vascular damage, have also been described. As yet, there has been little evidence that preventing or treating symptoms of the MetS protects patients from renal impairment. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
C1 [Gluba, Anna; Rysz, Jacek] Med Univ Lodz, Dept Nephrol Hypertens & Family Med, PL-90549 Lodz, Poland.
   [Mikhailidis, Dimitri P.] UCL, Sch Med, Dept Clin Biochem, London W1N 8AA, England.
   [Lip, Gregory Y. H.] Univ Birmingham, City Hosp, Ctr Cardiovasc Sci, Birmingham, W Midlands, England.
   [Hannam, Simon] Kings Coll London, Sch Med, Dept Child Hlth, London WC2R 2LS, England.
   [Banach, Maciej] Med Univ Lodz, Dept Hypertens, PL-90549 Lodz, Poland.
C3 Medical University Lodz; University of London; University College
   London; UCL Medical School; University of Birmingham; University of
   London; King's College London; Medical University Lodz
RP Banach, M (corresponding author), Med Univ Lodz, Dept Hypertens Nephrol & Hypertens, Zeromskiego 113, PL-90549 Lodz, Poland.
EM maciejbanach@aol.co.uk
RI Mikhailidis, Dimitri/A-1869-2013; Lip, Gregory/AEO-0575-2022; Banach,
   Maciej/A-1271-2009; Gluba-Sagr, Anna/AAG-3024-2019; Rysz,
   Jacek/L-8313-2013
OI Banach, Maciej/0000-0001-6690-6874; Gluba-Sagr,
   Anna/0000-0003-3322-5655; Rysz, Jacek/0000-0002-2757-6443
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NR 192
TC 75
Z9 78
U1 0
U2 37
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0167-5273
EI 1874-1754
J9 INT J CARDIOL
JI Int. J. Cardiol.
PD APR 5
PY 2013
VL 164
IS 2
BP 141
EP 150
DI 10.1016/j.ijcard.2012.01.013
PG 10
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 112NO
UT WOS:000316599200007
PM 22305775
DA 2025-06-11
ER

PT J
AU Millar, F
   Sands, N
   Elsom, S
AF Millar, Freyja
   Sands, Natisha
   Elsom, Stephen
TI Factors influencing cardiometabolic monitoring practices in an adult
   community mental health service
SO INTERNATIONAL JOURNAL OF MENTAL HEALTH NURSING
LA English
DT Article
DE cardiometabolic; community; mental health service; monitoring; serious
   mental illness
ID PHYSICAL HEALTH; METABOLIC SYNDROME; RISK-FACTORS;
   SCHIZOPHRENIA-PATIENTS; PSYCHIATRIC-PATIENTS; ANTIPSYCHOTIC-DRUGS;
   PSYCHOTIC DISORDERS; CARDIOVASCULAR RISK; TREATED PATIENTS; PEOPLE
AB People with serious mental illness are reported to live up to 25 years less than the general population. Cardiovascular disease and diabetes risk factors, as well as mental health, treatment, lifestyle, service provision, and socioeconomic factors, all contribute to this health inequity. Cardiometabolic monitoring (CMM) is one strategy used to attend to some cardiometabolic risk factors. The present study aimed to explore factors that influence decisions to undertake CMM in an Australian adult community mental health service. A CMM audit tool was designed to capture demographic, clinical, and care-provision factors. A 6-month retrospective file audit from the total population of consumers of an adult community mental health service was undertaken, where no existing CMM guidelines or practices were in place. The study findings confirmed a higher prevalence of cardiometabolic disorders in the study population compared to the general population. Complete CMM occurred in 24% of the study population (n=94). No consumer demographic, socioeconomic, or clinical characteristics, or care-provision factors, were found to be predictors of complete CMM. The random manner in which CMM was observed to occur in the study highlights the need for standardized CMM guidelines and capacity-building strategies to improve current CMM practices.
C1 [Millar, Freyja] Univ Melbourne, Eastern Hlth, Melbourne, Vic, Australia.
   [Elsom, Stephen] Univ Melbourne, Ctr Psychiat Nursing, Melbourne, Vic, Australia.
   [Sands, Natisha] Deakin Univ, Sch Nursing & Midwifery, Geelong, Vic 3217, Australia.
C3 Eastern Health; University of Melbourne; University of Melbourne; Deakin
   University
RP Millar, F (corresponding author), Eastern Hlth Adult Mental Hlth Serv, Level 1,43 Carrington Rd, Box Hill, Vic 3128, Australia.
EM freyjamillar@gmail.com
RI Elsom, Stephen/ABF-5413-2021; Sands, Natisha/ABF-5388-2021
OI Millar, Freyja/0000-0002-4770-3200
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NR 68
TC 11
Z9 12
U1 0
U2 15
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1445-8330
EI 1447-0349
J9 INT J MENT HEALTH NU
JI Int. J. Ment. Health Nurs.
PD DEC
PY 2014
VL 23
IS 6
BP 479
EP 489
DI 10.1111/inm.12085
PG 11
WC Nursing; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Psychiatry
GA AT8YU
UT WOS:000345215700002
PM 25069903
DA 2025-06-11
ER

PT J
AU Kim, MK
   Park, HJ
   Lee, KJ
AF Kim, Mi-Kyung
   Park, Hyo Jin
   Lee, Kyung Ju
TI Living lab modelling as a pilot study assessing the potential
   psychological health benefits of forest environment for cancer survivors
SO OBSTETRICS & GYNECOLOGY SCIENCE
LA English
DT Article
DE Forests; Relaxation therapy; Cancer survivors; Quality of life;
   Psychological well-being
ID QUALITY-OF-LIFE; WELL-BEING BENEFITS; METABOLIC SYNDROME;
   PHYSICAL-ACTIVITY; MORTALITY; THERAPY; ANXIETY; PREVALENCE; PEOPLE;
   WOMEN
AB Objective To evaluate the physiological and psychological changes in cancer survivors who engage in repeated forest therapy in a living environment. Methods This study included stay-based forest therapy for female cancer survivors aged >= 40 years. The program was conducted in two cycles, each spanning 3 weeks and consisting of a 2-night, 3-day stay, followed by daily life integration. The cycles were repeated from July 2, 2022, to August 18, 2022. Participant assessment included standard physical health parameters and a questionnaire on general characteristics, lifestyle habits, stress levels, and health status. Results Thirty-seven female cancer survivors participated in the forest healing program, 56.8% of whom had a history of breast cancer. The median body mass index (BMI) was 23.80 kg/m 2 (range, 21.00-25.60). More than half of the patients reported mild-to-moderate fatigue, chronic pain, and mild-to-moderate depression (81%, 65%, and 73%, respectively). After two cycles of forest therapy, no significant differences were observed in terms of fatigue, pain, or BMI levels. However, significant improvements were found in quality of life measures, particularly the psychological quality of life (mean score 12.54 at baseline vs. 13.48 after cycle 2; P=0.007). Positive improvements were also observed in terms of stress (mean score 17.03 vs. 13.76; P=0.002) and depression (mean score 8.35 vs. 6.11; P=0.002) levels. Conclusion Our forest-healing program demonstrated that nature-based therapies improve the mental health and quality of life of female cancer survivors, suggesting the need for further research on nature-based interventions to better support cancer survivors.
C1 [Kim, Mi-Kyung] Ewha Womans Univ, Mokdong Hosp, Coll Med, Dept Obstet & Gynecol, Seoul, South Korea.
   [Park, Hyo Jin] Ewha Womans Univ, Coll Med, Seoul Hosp, Dept Family Med, Seoul, South Korea.
   [Lee, Kyung Ju] Natl Rehabil Ctr, Dept Womens Rehabil, 58 Samgaksan Ro, Seoul 01022, South Korea.
C3 Ewha Womans University; Ewha Womans University
RP Lee, KJ (corresponding author), Natl Rehabil Ctr, Dept Womens Rehabil, 58 Samgaksan Ro, Seoul 01022, South Korea.
EM drlkj4094@korea.kr
RI Kim, Ee-Kyung/AAA-1068-2022
OI Lee, Kyung Ju/0000-0003-4655-1521
FU Korea Forestry Promotion Institute [2021384A00-2123-0101]
FX This research was funded by the Korea Forestry Promotion Institute
   (grant number: 2021384A00-2123-0101) .
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NR 40
TC 0
Z9 0
U1 2
U2 4
PU Korean Soc Obstetrics and Gynecology (KSOG)
PI Seoul
PA 4th Floor, 36 Gangnam-daero 132-gil, Gangnam-gu, Seoul, SOUTH KOREA
SN 2287-8572
EI 2287-8580
J9 OBSTET GYNECOL SCI
JI Obstet. Gynecol. Sci.
PD JUL
PY 2024
VL 67
IS 4
BP 404
EP 413
DI 10.5468/ogs.24035
PG 10
WC Obstetrics & Gynecology
WE Emerging Sources Citation Index (ESCI)
SC Obstetrics & Gynecology
GA ZH0H6
UT WOS:001274283000002
PM 38987994
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Abou Kassm, S
   Hoertel, N
   Naja, W
   McMahon, K
   Barriere, S
   Blumenstock, Y
   Portefaix, C
   Raucher-Chéné, D
   Béra-Potelle, C
   Cuervo-Lombard, C
   Guerin-Langlois, C
   Lemogne, C
   Peyre, H
   Kaladjian, A
   Limosin, F
   Adès, J
   Alezrah, C
   Amado, I
   Amar, G
   Andréi, O
   Arbault, D
   Archambault, G
   Aucouturier, P
   Aurifeuille, G
   Bardou, H
   Bareil-Guérin, M
   Barrau, P
   Barrouillet, C
   Baup, E
   Bazin, N
   Beaufils, B
   Ben Ayed, J
   Benoit, M
   Benyacoub, K
   Bichet, T
   Blanadet, F
   Blanc, O
   Blanc-Comiti, J
   Boussiron, D
   Bouysse, AM
   Brochard, A
   Brochart, O
   Bucheron, B
   Cabot, M
   Camus, V
   Chabannes, JM
   Chariot, V
   Charpeaud, T
   Chatellier, G
   Chevance, A
   Clad-Mor, C
   Combes, C
   Comisu, M
   Cordier, S
   Costi, F
   Courcelles, JP
   Creixell, M
   Cuche, H
   Dammak, A
   Da Rin, D
   Denis, JB
   Denizot, H
   Deperthuis, A
   Diers, E
   Dirami, S
   Donneau, D
   Dreano, P
   Dubertret, C
   Duprat, E
   Duthoit, D
   Fernandez, C
   Fonfrede, P
   Freitas, N
   Frigout, Y
   Gasnier, P
   Gauillard, J
   Getten, F
   Gierski, F
   Godart, F
   Gourevitch, R
   Delyle, AG
   Gremion, J
   Gres, H
   Griner, V
   Guggiari, C
   Guillin, O
   Hadaoui, H
   Haffen, E
   Hanon, C
   SadeqHaouzir
   Hazif-Thomas, C
   Heron, A
   Hubsch, B
   Jalenques, I
   Januel, D
   Karnycheff, JF
   Kebir, O
   Krebs, MO
   Lajugie, C
   Leboyer, M
   Legrand, P
   Lejoyeux, M
   Lemaire, V
   Leroy, E
   Levy-Chavagnat, D
   Leydier, A
   Liling, C
   Llorca, PM
   Loeffel, P
   Louville, P
   Navarro, SL
   Mages, N
   Mahi, M
   Maillet, O
   Manetti, A
   Martelli, C
   Martin, P
   Masson, M
   Maurs-Ferrer, I
   Mauvieux, J
   Mazmanian, S
   Mechin, E
   Mekaoui, L
   Meniai, M
   Metton, A
   Mihoubi, A
   Miron, M
   Mora, G
   Adès, VN
   Nubukpo, P
   Omnes, C
   Papin, S
   Paris, P
   Passerieux, C
   Pellerin, J
   Perron, S
   Petit, A
   Petitjean, F
   Pringuey, D
   Radtchenko, A
   Rahiou, H
   Rauzy, A
   Reinheimer, L
   Renard, M
   Rene, M
   Rengade, CE
   Reynaud, P
   Robin, D
   Rodrigues, C
   Rollet, A
   Rondepierre, F
   Rousselot, B
   Rubingher, S
   Saba, G
   Salvarelli, JP
   Samuelian, JC
   Scemama-Ammar, C
   Schurhoff, F
   Schuster, JP
   Sechter, D
   Segalas, B
   Seguret, T
   Seigneurie, AS
   Semmak, A
   Slama, F
   Taisne, S
   Taleb, M
   Terra, JL
   Thefenne, D
   Tran, E
   Tourtauchaux, R
   Vacheron, MN
   Vandel, P
   Vanhoucke, V
   Venet, E
   Verdoux, H
   Viala, A
   Vidon, G
   Vitre, M
   Vurpas, JL
   Wagermez, C
   Walter, M
   Yon, L
   Zendjidjian, X
AF Abou Kassm, Sandra
   Hoertel, Nicolas
   Naja, Wadih
   McMahon, Kibby
   Barriere, Sarah
   Blumenstock, Yvonne
   Portefaix, Christophe
   Raucher-Chene, Delphine
   Bera-Potelle, Celine
   Cuervo-Lombard, Christine
   Guerin-Langlois, Christophe
   Lemogne, Cedric
   Peyre, Hugo
   Kaladjian, Arthur
   Limosin, Frederic
   Ades, Jean
   Alezrah, Charles
   Amado, Isabelle
   Amar, Gilles
   Andrei, Ovidiu
   Arbault, Denis
   Archambault, Georges
   Aucouturier, Pascaline
   Aurifeuille, Gilles
   Bardou, Herve
   Bareil-Guerin, Michele
   Barrau, Pierre
   Barrouillet, Claudine
   Baup, Emilie
   Bazin, Nadine
   Beaufils, Beatrice
   Ben Ayed, Jalel
   Benoit, Michel
   Benyacoub, Kader
   Bichet, Therese
   Blanadet, Francoise
   Blanc, Olivier
   Blanc-Comiti, Julien
   Boussiron, Didier
   Bouysse, Anne-Marie
   Brochard, Alain
   Brochart, Olivier
   Bucheron, Bastien
   Cabot, Marion
   Camus, Vincent
   Chabannes, Jean -Marc
   Chariot, Veronique
   Charpeaud, Thomas
   Chatellier, Gilles
   Chevance, Astrid
   Clad-Mor, Cateline
   Combes, Colette
   Comisu, Maricela
   Cordier, Sylvain
   Costi, Francois
   Courcelles, Jean-Paul
   Creixell, Mercedes
   Cuche, Henry
   Dammak, Anis
   Da Rin, David
   Denis, Jean -Bernard
   Denizot, Helene
   Deperthuis, Anne
   Diers, Eric
   Dirami, Smail
   Donneau, Didier
   Dreano, Pierre
   Dubertret, Caroline
   Duprat, Eric
   Duthoit, Didier
   Fernandez, Christian
   Fonfrede, Philippe
   Freitas, Nelly
   Frigout, Yann
   Gasnier, Philippe
   Gauillard, Jacques
   Getten, Fabien
   Gierski, Fabien
   Godart, Fabien
   Gourevitch, Raphael
   Delyle, Aude Grassin
   Gremion, Juliette
   Gres, Helene
   Griner, Veronique
   Guggiari, Christian
   Guillin, Olivier
   Hadaoui, Hamadi
   Haffen, Emmanuel
   Hanon, Cecile
   SadeqHaouzir
   Hazif-Thomas, Cyril
   Heron, Anne
   Hubsch, Berengere
   Jalenques, Isabelle
   Januel, Dominique
   Karnycheff, Jean-Francois
   Kebir, Oussama
   Krebs, Marie-Odile
   Lajugie, Christine
   Leboyer, Marion
   Legrand, Pierre
   Lejoyeux, Michel
   Lemaire, Vincent
   Leroy, Evelyne
   Levy-Chavagnat, Diane
   Leydier, Antoine
   Liling, Chantal
   Llorca, Pierre -Michel
   Loeffel, Philippe
   Louville, Patrice
   Navarro, Stephane Lucas
   Mages, Nicolas
   Mahi, Mohamed
   Maillet, Odile
   Manetti, Aude
   Martelli, Catherine
   Martin, Pascal
   Masson, Marc
   Maurs-Ferrer, Isabelle
   Mauvieux, JoeIle
   Mazmanian, Sylvain
   Mechin, Emmanuelle
   Mekaoui, Lila
   Meniai, Mostefa
   Metton, Agnes
   Mihoubi, Amine
   Miron, Maria
   Mora, Genevieve
   Ades, Valerie Niro
   Nubukpo, Philippe
   Omnes, Cecile
   Papin, Stephanie
   Paris, Pierre
   Passerieux, Christine
   Pellerin, Jerome
   Perron, Sylvie
   Petit, Annie
   Petitjean, Francois
   Pringuey, Dominique
   Radtchenko, Andrei
   Rahiou, Hassan
   Rauzy, Anne
   Reinheimer, Lionel
   Renard, Michel
   Rene, Margaux
   Rengade, Charles-Edouard
   Reynaud, Paul
   Robin, Didier
   Rodrigues, Christelle
   Rollet, Aurelie
   Rondepierre, Fabien
   Rousselot, Bernard
   Rubingher, Sarah
   Saba, Ghassen
   Salvarelli, Jean-Pierre
   Samuelian, Jean-Claude
   Scemama-Ammar, Corinne
   Schurhoff, Franck
   Schuster, Jean-Pierre
   Sechter, Daniel
   Segalas, Beatrice
   Seguret, Tiphaine
   Seigneurie, Anne-Sophie
   Semmak, Amina
   Slama, Frederic
   Taisne, Sophie
   Taleb, Mohamed
   Terra, Jean-Louis
   Thefenne, Dominique
   Tran, Eric
   Tourtauchaux, Remi
   Vacheron, Marie-Noelle
   Vandel, Pierre
   Vanhoucke, Valerie
   Venet, Emmanuel
   Verdoux, Helene
   Viala, Anne
   Vidon, Gilles
   Vitre, Murielle
   Vurpas, Jean-Luc
   Wagermez, Carole
   Walter, Michel
   Yon, Liova
   Zendjidjian, Xavier
CA CSA Study Grp
TI Metabolic syndrome among older adults with schizophrenia spectrum
   disorder: Prevalence and associated factors in a multicenter study
SO PSYCHIATRY RESEARCH
LA English
DT Article
DE Metabolic syndrome; Schizophrenia; Older; Geriatric; Hypertension;
   Antipsychotic; Screening; Obesity
ID STUDIES DEPRESSION SCALE; MENTAL-HEALTH-CARE; CES-D;
   CARDIOVASCULAR-DISEASE; GLOBAL ASSESSMENT; RISK; MORTALITY;
   ANTIPSYCHOTICS; LIFE; METAANALYSIS
AB Metabolic syndrome and its associated morbidity and mortality have been well documented in adults with schizophrenia. However, data is lacking for their geriatric counterparts. We sought to investigate the frequency of screening and the prevalence of metabolic syndrome in older adults with schizophrenia, as well as its possible correlates, using the Cohort of individuals with schizophrenia Aged 55 years or more study (n = 353). We found that 42.2% (n = 149) of our sample was screened for metabolic syndrome. Almost half of those (n = 77; 51.7%) screened positive according to ATPIII criteria. Hypertension and abdominal obesity were the two most prevalent metabolic abnormalities. Screening was positively associated with male gender and urbanicity, and metabolic syndrome diagnosis was positively associated with cardiovascular disorders and consultation with a general practitioner (all p < 0.05). However, there were no significant associations of metabolic syndrome with socio-demographic or clinical characteristics, psychotropic medications, other medical conditions and other indicators of mental health care utilization. Our findings support that the prevalence of metabolic syndrome among older adults with schizophrenia spectrum disorder is high and screening is crucial mainly in those patients with hypertension and/or abdominal obesity. Factors at play might be different than those in the younger population.
C1 [Abou Kassm, Sandra; Naja, Wadih] Lebanese Univ, Fac Med Sci, Dept Psychiat, Beirut, Lebanon.
   [Hoertel, Nicolas; Blumenstock, Yvonne; Guerin-Langlois, Christophe; Lemogne, Cedric; Limosin, Frederic] Western Paris Univ Hosp, AP HP, Dept Psychiat, F-92130 Issy Les Moulineaux, France.
   [Hoertel, Nicolas; Guerin-Langlois, Christophe; Lemogne, Cedric; Limosin, Frederic] Paris Descartes Univ, Sorbonne Paris Cite, Psychiat & Neurosci Ctr, INSERM,UMR 894, Paris, France.
   [McMahon, Kibby] Duke Univ, Dept Psychol & Neurosci, 2213 Elba St, Durham, NC 27710 USA.
   [Barriere, Sarah; Raucher-Chene, Delphine; Bera-Potelle, Celine; Cuervo-Lombard, Christine; Kaladjian, Arthur] Reims Univ Hosp, Robert Debre Hosp, Dept Psychiat, Reims, France.
   [Portefaix, Christophe] Reims Univ Hosp, Maison Blanche Hosp, Dept Med Imaging, Reims, France.
   [Portefaix, Christophe] Univ Reims, CReSTIC Lab, EA 3804, Reims, France.
   [Raucher-Chene, Delphine; Kaladjian, Arthur] Univ Reims, Cognit Hlth & Soc Lab, EA 6291, Reims, France.
   [Cuervo-Lombard, Christine] Toulouse 2 Jean Jaures Univ, CERPPS Lab, Dept Psychol, EA 7411, Toulouse, France.
   [Peyre, Hugo] Robert Debre Hosp, AP HP, Child & Adolescent Psychiat Dept, Paris, France.
   [Peyre, Hugo] Ecole Normale Super, Cognit Sci & Psycholinguist Lab, Paris, France.
C3 Lebanese University; Assistance Publique Hopitaux Paris (APHP);
   Universite Paris Cite; Hopital Universitaire Corentin-Celton - APHP;
   Universite Paris Cite; Institut National de la Sante et de la Recherche
   Medicale (Inserm); Duke University; CHU de Reims; Universite de Reims
   Champagne-Ardenne; Universite de Reims Champagne-Ardenne; CHU de Reims;
   Universite de Reims Champagne-Ardenne; Universite de Reims
   Champagne-Ardenne; Universite de Toulouse; Assistance Publique Hopitaux
   Paris (APHP); Universite Paris Cite; Hopital Universitaire Robert-Debre
   - APHP; Universite PSL; Ecole Normale Superieure (ENS)
RP Abou Kassm, S (corresponding author), Mt Lebanon Hosp, Blvd Camille Chamoun, Beirut, Lebanon.; Abou Kassm, S (corresponding author), POB 470, Hazmieh, Lebanon.
EM sandra_akassm@hotmail.com
RI Paris, Pierre-Henri/JAZ-1606-2023; Chevance, Astrid/AFV-8415-2022; Fond,
   Guillaume/D-7646-2011; Krebs, Marie-Odile/O-2104-2017; GIERSKI,
   Fabien/C-5714-2015; Abou Kassm, Sandra/AAU-5478-2021; Rondepierre,
   Fabien/MDS-5540-2025; Leboyer, Marion/AAW-3648-2021; Lemaire,
   Vincent/D-7610-2013; Raucher-Chéné, Delphine/L-7636-2019; Nubukpo,
   Philippe/KXR-1904-2024; Camus, Vincent/ABC-4021-2020; Lemogne,
   Cédric/Q-6091-2019; haffen, emmanuel/R-2765-2017; Hoertel,
   Nicolas/H-9457-2015; Heron, Anne/KAL-8499-2024
OI haffen, emmanuel/0000-0002-4091-518X; BARRIERE,
   Sarah/0000-0001-7828-8778; Cuervo-Lombard,
   Christine-Vanessa/0000-0002-2926-8639; Hoertel,
   Nicolas/0000-0002-7890-1349; Vandel, Pierre/0000-0002-0189-8364;
   RAUCHER-CHENE, DELPHINE/0000-0002-5663-4454; Heron,
   Anne/0000-0002-2277-7262
FU French Ministry of Health and Social Affairs [PHRC 2008-N11-01]
FX This study was supported by a grant from the French Ministry of Health
   and Social Affairs (PHRC 2008-N11-01)
   (http://solidaritessante.gouv.fr/).It was promoted by the University of
   Reims Champagne-Ardenne (http://www.univ-reims.fr/) and the University
   Paris -Descartes (https://www.univ-paris5.fr/).The funders had no role
   in study design, data collection and analysis, decision to publish, or
   preparation of the manuscript. We thank the Clinical Research Unit of
   Georges Pompidou European Hospital, and in particular Pr Gilles
   Chatellier, Mr Yann Frigout and Mrs Pascaline Aucouturier, and the
   Clinical Research Unit of Robert Debre Hospital, and in particular Mrs
   Sarah Rubingher, Dr Berengere Hubsch, Dr Eric Tran, Dr Fabien Gierski
   and Mr David Da Rin. We warmly thank all the patients and the
   investigators who made this study possible. Members (i.e. investigators)
   of the CSA (Cohort of individuals with Schizophrenia Aged 55 years or
   more) Study group are: Jean Ades, Charles Alezrah, Isabelle Amado,
   Gilles Amar, Ovidiu Andrei, Denis Arbault, Georges Archambault,
   Pascaline Aucouturier, Gilles Aurifeuille, Herve Bardou, Michele
   BareilGuerin, Pierre Barrau, Claudine Barrouillet, Emilie Baup, Nadine
   Bazin, Beatrice Beaufils, Jalel Ben Ayed, Michel Benoit, Kader
   Benyacoub, Therese Bichet, Francoise Blanadet, Olivier Blanc, Julien
   Blanc-Comiti, Didier Boussiron, Anne-Marie Bouysse, Alain Brochard,
   Olivier Brochart, Bastien Bucheron, Marion Cabot, Vincent Camus,
   Jean-Marc Chabannes, Veronique Chariot, Thomas Charpeaud, Gilles
   Chatellier, Astrid Chevance, Cateline Clad-Mor, Colette Combes, Maricela
   Comisu, Sylvain Cordier, Francois Costi, Jean-Paul Courcelles, Mercedes
   Creixell, Henry Cuche, Anis Dammak, David Da Rin, Jean-Bernard Denis,
   Helene Denizot, Anne Deperthuis, Eric Diers, Smail Dirami, Didier
   Donneau, Pierre Dreano, Caroline Dubertret, Eric Duprat, Didier Duthoit,
   Christian Fernandez, Philippe Fonfrede, Nelly Freitas, Yann Frigout,
   Philippe Gasnier, Jacques Gauillard, Fabien Getten, Fabien Gierski,
   Fabien Godart, Raphael Gourevitch, Aude Grassin Delyle, Juliette
   Gremion, Helene Gres, Veronique Griner, Christian Guggiari, Olivier
   Guillin, Hamadi Hadaoui, Emmanuel Haffen, Cecile Hanon, SadeqHaouzir,
   Cyril Hazif-Thomas, Anne Heron, Berengere Hubsch, Isabelle Jalenques,
   Dominique Januel, Jean-Francois Karnycheff, Oussama Kebir, Marie-Odile
   Krebs, Christine Lajugie, Marion Leboyer, Pierre Legrand, Michel
   Lejoyeux, Vincent Lemaire, Evelyne Leroy, Diane Levy-Chavagnat, Antoine
   Leydier, Chantal Liling, Pierre-Michel Llorca, Philippe Loeffel, Patrice
   Louville, Stephane Lucas Navarro, Nicolas Mages, Mohamed Mahi, Odile
   Maillet, Aude Manetti, Catherine Martelli, Pascal Martin, Marc Masson,
   Isabelle Maurs-Ferrer, JoeIle Mauvieux, Sylvain Mazmanian, Emmanuelle
   Mechin, Lila Mekaoui, Mostefa Meniai, Agnes Metton, Amine Mihoubi, Maria
   Miron, Genevieve Mora, Valerie Niro Ades, Philippe Nubukpo, Cecile
   Omnes, Stephanie Papin, Pierre Paris, Christine Passerieux, Jerome
   Pellerin, Sylvie Perron, Annie Petit, Francois Petitjean, Dominique
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NR 66
TC 34
Z9 34
U1 0
U2 10
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0165-1781
J9 PSYCHIAT RES
JI Psychiatry Res.
PD MAY
PY 2019
VL 275
BP 238
EP 246
DI 10.1016/j.psychres.2019.03.036
PG 9
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA HZ9DQ
UT WOS:000469156400034
PM 30933701
DA 2025-06-11
ER

PT J
AU Devaraj, S
   Singh, U
   Jialal, I
AF Devaraj, Sridevi
   Singh, Uma
   Jialal, Ishwarlal
TI Human C-reactive protein and the metabolic syndrome
SO CURRENT OPINION IN LIPIDOLOGY
LA English
DT Review
DE C-reactive protein; inflammation; metabolic syndrome; vascular cells
ID CORONARY-HEART-DISEASE; ACTIVATOR INHIBITOR-1 EXPRESSION;
   INSULIN-RESISTANCE SYNDROME; ENDOTHELIAL DYSFUNCTION; OXIDATIVE STRESS;
   CARDIOVASCULAR-DISEASE; MYOCARDIAL-INFARCTION; DIABETES-MELLITUS;
   BRACHIAL-ARTERY; ELEVATED LEVELS
AB Purpose of review
   Low-grade inflammation is characteristic of the metabolic syndrome (MetS). C-reactive protein (CRP), the best characterized biomarker of inflammation, is also an independent predictor of future cardiovascular events. The purpose of this review is to outline the role of inflammation and high sensitivity CRP in the MetS.
   Recent findings
   Emerging laboratory and epidemiological data now link inflammation and high sensitivity CRP to insulin resistance and adiposity and other features of MetS. Furthermore, in large prospective studies, increased high sensitivity CRP levels in MetS confer greater cardiovascular risk. CRP has been shown to impair insulin signaling and contributes to atherothrombosis.
   Summary
   Thus, although a high CRP level predisposes to increased cardiovascular risk in MetS, future investigation is warranted on the in-vivo role of CRP in mediating vascular effects and resulting in increased cardiovascular events in MetS patients.
C1 [Jialal, Ishwarlal] Univ Calif Davis, Med Ctr, Lab Atherosclerosis & Metab Res, Sacramento, CA 95817 USA.
C3 University of California System; University of California Davis
RP Jialal, I (corresponding author), Univ Calif Davis, Med Ctr, Lab Atherosclerosis & Metab Res, 4635 2nd Ave,Res 1 Bldg,Room 3000, Sacramento, CA 95817 USA.
EM ishwarlal.jialal@ucdmc.ucdavis.edu
RI Jialal, Ishwarlal/AAG-6218-2019
FU National Institutes of Health (NIH) [K24 AT 00596, HL 074360]
FX The study is supported by grants: National Institutes of Health (NIH)
   K24 AT 00596 and NIH HL 074360.
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NR 91
TC 191
Z9 220
U1 0
U2 13
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0957-9672
EI 1473-6535
J9 CURR OPIN LIPIDOL
JI Curr. Opin. Lipidology
PD JUN
PY 2009
VL 20
IS 3
BP 182
EP 189
DI 10.1097/MOL.0b013e32832ac03e
PG 8
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism; Peripheral
   Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism;
   Cardiovascular System & Cardiology
GA 450TE
UT WOS:000266422900005
PM 19369869
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Gaysina, D
   Pierce, M
   Richards, M
   Hotopf, M
   Kuh, D
   Hardy, R
AF Gaysina, Darya
   Pierce, Mary
   Richards, Marcus
   Hotopf, Matthew
   Kuh, Diana
   Hardy, Rebecca
TI Association between adolescent emotional problems and metabolic
   syndrome: The modifying effect of C-reactive protein gene (CRP)
   polymorphisms
SO BRAIN BEHAVIOR AND IMMUNITY
LA English
DT Article
DE Inflammation; Obesity; Depression; Anxiety; CRP; Gene
ID CORONARY-HEART-DISEASE; 3RD NATIONAL-HEALTH; DEPRESSIVE SYMPTOMS;
   ANXIETY DISORDERS; CARDIOVASCULAR-DISEASE; MAJOR DEPRESSION;
   INFLAMMATION; COMORBIDITY; PREVALENCE; CHILDHOOD
AB Depression is associated with the development of the metabolic syndrome, and both depression and metabolic syndrome are associated with markers of systemic inflammation, such as C-reactive protein (CRP). We examined associations between affective status in adolescence and adulthood, and the metabolic syndrome at age 53 years in a large representative British birth cohort. We also investigated whether two CRP gene polymorphisms (rs1205 and rs3093068) were associated with affective status and the metabolic syndrome, and whether the association between affective status and the metabolic syndrome was modified by these CRP polymorphisms. Women, but not men, with emotional problems in adolescence were more likely to have the metabolic syndrome (OR= 1.53, 95% CI: 1.04, 2.26), although this sex difference was not statistically significant (p = 0.22). The CRP SNPs were not associated with affective status or the metabolic syndrome, but the association of adolescent emotional problems with the metabolic syndrome was stronger in those who were homozygous for the major allele (C) of rs1205 (OR = 1.83, 95% CI: 1.17, 2.86) than in carriers of the T allele (OR = 1.01,95% CI: 0.66, 1.55) (p = 0.05 for gene by affective status interaction). This interaction was stronger when considering adolescent emotional problems as a continuous variable (p = 0.003). Adolescent emotional problems play an important role in the development of the metabolic syndrome later in life, particularly in those homozygous for the major allele of CRP rs1205. These findings may highlight new ways of identifying people with emotional problems at high risk of developing the metabolic syndrome, which is of great importance for the management of the physical health of these patients. (C) 2011 Elsevier Inc. All rights reserved.
C1 [Gaysina, Darya; Pierce, Mary; Richards, Marcus; Kuh, Diana; Hardy, Rebecca] UCL, MRC Unit Lifelong Hlth & Ageing, London WC1B 5JU, England.
   [Hotopf, Matthew] Kings Coll London, Inst Psychiat, London WC2R 2LS, England.
C3 University of London; University College London; University of London;
   King's College London
RP Gaysina, D (corresponding author), UCL, MRC Unit Lifelong Hlth & Ageing, 33 Bedford Pl, London WC1B 5JU, England.
EM d.gaysina@nshd.mrc.ac.uk
RI Hardy, Rebecca/AFR-1989-2022; Hotopf, Matthew/E-4971-2010; Kuh,
   Diana/L-6019-2014; Gaysina, Darya/J-5720-2013; Stefanadis,
   Christodoulos/ABH-2232-2020
OI Hardy, Rebecca/0000-0001-9949-0799; Richards,
   Marcus/0000-0001-9191-2192; Stefanadis,
   Christodoulos/0000-0001-5974-6454; Hotopf, Matthew/0000-0002-3980-4466;
   Gaysina, Darya/0000-0002-9283-5667
FU Medical Research Council; NIHR South London; Maudsley NHS Foundation
   Trust Specialist Biomedical Research Centre; MRC [MC_U123092731,
   MC_U123092722, MC_U123092721] Funding Source: UKRI
FX This work was supported by Medical Research Council [to D.G., MR., D.K.
   and R.H.]; and by the NIHR South London and Maudsley NHS Foundation
   Trust Specialist Biomedical Research Centre [to M.H.].
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NR 73
TC 23
Z9 27
U1 0
U2 7
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0889-1591
EI 1090-2139
J9 BRAIN BEHAV IMMUN
JI Brain Behav. Immun.
PD MAY
PY 2011
VL 25
IS 4
BP 750
EP 758
DI 10.1016/j.bbi.2011.01.019
PG 9
WC Immunology; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Neurosciences & Neurology; Psychiatry
GA 762GN
UT WOS:000290463100018
PM 21296145
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Cozma, S
   Dima-Cozma, LC
   Ghiciuc, CM
   Pasquali, V
   Saponaro, A
   Patacchioli, FR
AF Cozma, S.
   Dima-Cozma, L. C.
   Ghiciuc, C. M.
   Pasquali, V.
   Saponaro, A.
   Patacchioli, F. R.
TI Salivary cortisol and α-amylase: subclinical indicators of stress as
   cardiometabolic risk
SO BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
LA English
DT Article
DE Salivary stress biomarkers; Cardiometabolic risk (factors); Stress;
   Hypothalamic-pituitary-adrenal axis; Sympathetic adrenomedullary system
ID RANDOMIZED CONTROLLED-TRIAL; AUTONOMIC NERVOUS-SYSTEM; OBSTRUCTIVE
   SLEEP-APNEA; ACUTE PSYCHOLOGICAL STRESS; SOCIAL EVALUATIVE THREAT;
   HEALTHY MALE-SUBJECTS; PHYSIOLOGICAL-RESPONSES; PSYCHOSOCIAL STRESS;
   AWAKENING RESPONSE; ALLOSTATIC LOAD
AB Currently, the potential for cardiovascular (CV) stress-induced risk is primarily based on the theoretical (obvious) side effects of stress on the CV system. Salivary cortisol and alpha-amylase, produced respectively by the hypothalamus-pituitary-adrenal (HPA) axis and the sympathetic-adrenomedullary (SAM) system during stress response, are still not included in the routine evaluation of CV risk and require additional and definitive validation. Therefore, this article overviews studies published between 2010 and 2015, in which salivary cortisol and a-amylase were measured as stress biomarkers to examine their associations with CV/CMR (cardiometabolic risk) clinical and subclinical indicators. A comprehensive search of PubMed, Web of Science and Scopus electronic databases was performed, and 54 key articles related to the use of salivary cortisol and alpha-amylase as subclinical indicators of stress and CV/CMR factors, including studies that emphasized methodological biases that could influence the accuracy of study outcomes, were ultimately identified. Overall, the biological impact of stress measured by salivary cortisol and alpha-amylase was associated with CV/CMR factors. Results supported the use of salivary cortisol and alpha-amylase as potential diagnostic tools for detecting stress-induced cardiac diseases and especially to describe the mechanisms by which stress potentially contributes to the pathogenesis and outcomes of CV diseases.
C1 [Cozma, S.] Univ Med & Pharm Grigore T Popa, Sch Med, Dept Otorhinolaryngol, Iasi, Romania.
   [Dima-Cozma, L. C.] Univ Med & Pharm Grigore T Popa, Sch Med, Dept Internal Med, Iasi, Romania.
   [Ghiciuc, C. M.] Univ Med & Pharm Grigore T Popa, Sch Med, Dept Pharmacol, Iasi, Romania.
   [Pasquali, V.] Sapienza Univ Rome, Dept Psychol, Rome, Italy.
   [Saponaro, A.; Patacchioli, F. R.] Sapienza Univ Rome, Dept Physiol & Pharmacol V Erspamer, Rome, Italy.
C3 Grigore T Popa University of Medicine & Pharmacy; Grigore T Popa
   University of Medicine & Pharmacy; Grigore T Popa University of Medicine
   & Pharmacy; Sapienza University Rome; Sapienza University Rome
RP Patacchioli, FR (corresponding author), Sapienza Univ Rome, Dept Physiol & Pharmacol V Erspamer, Rome, Italy.
EM francesca.patacchioli@uniroma1.it
RI Ghiciuc, Cristina/AAA-3942-2019; Patacchioli, Francesca
   Romana/AAD-4183-2022
OI Pasquali, Vittorio/0000-0003-1294-0254
FU University of Medicine and Pharmacy "Grigore T. Popa'' - Iasi [29234]
FX This study was partially supported by the University of Medicine and
   Pharmacy "Grigore T. Popa'' - Iasi through grant No. 29234/December 20,
   2013 to L.C. Dima-Cozma.
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NR 87
TC 62
Z9 69
U1 0
U2 27
PU ASSOC BRAS DIVULG CIENTIFICA
PI SAO PAULO
PA FACULDADE MEDICINA, SALA 21, 14049 RIBEIRAO PRETO, SAO PAULO, 00, BRAZIL
SN 0100-879X
EI 1678-4510
J9 BRAZ J MED BIOL RES
JI Brazilian J. Med. Biol. Res.
PY 2017
VL 50
IS 2
AR e5577
DI 10.1590/1414-431X20165577
PG 8
WC Biology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Life Sciences & Biomedicine - Other Topics; Research & Experimental
   Medicine
GA EK7ZU
UT WOS:000394144500005
PM 28177057
OA gold, Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Butnoriene, J
   Bunevicius, A
   Norkus, A
   Bunevicius, R
AF Butnoriene, Jurate
   Bunevicius, Adomas
   Norkus, Antanas
   Bunevicius, Robertas
TI Depression but not anxiety is associated with metabolic syndrome in
   primary care based community sample
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE Depression; Anxiety; Metabolic syndrome; Primary care
ID CORONARY-ARTERY-DISEASE; 3RD NATIONAL-HEALTH; MAJOR DEPRESSION; HOSPITAL
   ANXIETY; PREVALENCE; DISORDERS; COMORBIDITY; ADULTS
AB Introduction: Metabolic syndrome (MetS) and depression are considered important risk factors for diabetes and cardiovascular disease. Recent evidence suggests that depression can be an important predictor of MetS. Data on the association between anxiety and MetS remain mixed. In a large primary care based community sample we investigated an association of depressive and anxiety disorders and symptoms with MetS.
   Methods: A total of 1115 (51% men, mean age 62.0 +/- 9.6 years) randomly selected individuals of 45 years and older were evaluated for: (i) MetS using the World Health Organization (WHO), National Cholesterol Education Program Adult Treatment Panel III (NCEP/ATP III) and International Diabetes Federation (IDF) criteria; (ii) current major depressive episode (MDE) and current generalized anxiety disorder (GAD), the Mini International Neuropsychiatric interview; (iii) lifetime MDE; and (iv) symptoms of depression and anxiety, the Hospital Anxiety and Depression scale (HADS). Socio-demographic characteristics (education, residence, marital status and social status) and medical histories (physical activity, smoking status, alcohol consumption and histories of myocardial infarction and stroke) were also evaluated.
   Results: After adjusting for socio-demographic status, medical histories and current GAD, current MDE and lifetime MDE were associated with greater prevalence of MetS according to the WHO criteria (OR=1.7, 95%CI [1.1-2.7] and OR=3.7, 95%CI [2.4-5.7], respectively, p <= 0.001). Lifetime MDE was also associated with MetS according to the IDF and NCEP/ATP III criteria. On the other hand, current GAD was not associated with MetS in multivariate regression models when adjusted for current MDE. Similar results were obtained when evaluating an association between depression/anxiety symptoms and MetS, since elevated depressive, but not anxiety, symptoms were independently associated with MetS.
   Conclusions: Depressive, but not anxiety, disorders and symptoms are associated with greater prevalence rate of MetS. Assessment and management of MetS risk factors should be considered in depressed individuals. (C) 2013 Elsevier Ltd. All rights reserved.
C1 [Butnoriene, Jurate; Norkus, Antanas] Lithuanian Univ Hlth Sci, Dept Endocrinol, LT-50161 Kaunas, Lithuania.
   [Butnoriene, Jurate; Norkus, Antanas] Lithuanian Univ Hlth Sci, Inst Endocrinol, LT-50161 Kaunas, Lithuania.
   [Bunevicius, Adomas; Bunevicius, Robertas] Lithuanian Univ Hlth Sci, Behav Med Inst, Palanga, Lithuania.
C3 Lithuanian University of Health Sciences; Lithuanian University of
   Health Sciences; Lithuanian University of Health Sciences
RP Butnoriene, J (corresponding author), Lithuanian Univ Hlth Sci, Dept Endocrinol, Eiveniu Str 2, LT-50161 Kaunas, Lithuania.
EM juratebutnoriene@yahoo.com
RI Bunevicius, Adomas/I-3394-2019
OI Bunevicius, Adomas/0000-0003-0446-6898
FU Research Council of Lithuania
FX No pharmaceutical company or commercial organization had any role in the
   writing of this paper for publication. The original study, including
   collection, management, analysis and interpretation of the data was
   supported by funding from the Research Council of Lithuania.
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NR 40
TC 54
Z9 59
U1 0
U2 19
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD FEB
PY 2014
VL 40
BP 269
EP 276
DI 10.1016/j.psyneuen.2013.11.002
PG 8
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA AB6TB
UT WOS:000331921300029
PM 24485498
DA 2025-06-11
ER

PT J
AU Chan, WL
   Wong, YL
   Tai, YL
   Liu, M
   Yun, B
   Zhang, YN
   Hou, HLY
   Kwong, D
   Lee, VHF
   Lam, WWT
AF Chan, Wing-Lok
   Wong, Yat-Lam
   Tai, Yin-Ling
   Liu, Michelle
   Yun, Bryan
   Zhang, Yuning
   Hou, Holly Li-Yu
   Kwong, Dora
   Lee, Victor Ho-Fun
   Lam, Wendy Wing-Tak
TI Digital Rehabilitation Program for Breast Cancer Survivors on Adjuvant
   Hormonal Therapy: A Feasibility Study
SO CANCERS
LA English
DT Article
DE breast cancer; hormonal therapy; digital rehabilitation; mobile
   app-based intervention; survivor; cognition; depression
ID COGNITIVE DYSFUNCTION; EUROPEAN-ORGANIZATION; METABOLIC SYNDROME;
   HOSPITAL ANXIETY; WEIGHT-GAIN; QUESTIONNAIRE; DEPRESSION; PREVALENCE;
   OLDER
AB Background: Breast cancer survivors often face physical and psychological challenges, including weight gain, metabolic syndrome, and reduced quality of life. To address these concerns, a mobile app-based rehabilitation program called "THRIVE" was developed to improve physical activity, medication adherence, and health-related quality of life (HRQoL) in this population. Methods: This prospective, single-arm study assessed the feasibility and effectiveness of the "THRIVE" app among breast cancer survivors undergoing hormonal therapy. Participants were recruited from Queen Mary Hospital in Hong Kong between December 2022 and June 2023. Eligible survivors had completed treatment within the last five years or had stable advanced disease on hormonal therapy. Participants monitored their exercise, medication adherence, and self-care via the app and a Fitbit activity tracker for 16 weeks. Primary outcomes included recruitment, dropout, adherence rates, and safety. Secondary outcomes, measured at baseline and week 16, included physical activity intensity, HRQoL, psychological stress, body composition, and app satisfaction. Results: A total of 50 participants, with a median age of 53 years, completed the study. The recruitment rate was 70.4% with no dropouts. The adherence rate, measured by completing exercises recommended in the mobile app at least three times per week, was 74%. No severe adverse events were reported. While physical activity intensity showed no significant changes from baseline to week 16 (p = 0.24), cognitive function (p = 0.021), future perspective (p = 0.044), arm symptoms (p = 0.042), depression (p = 0.01), and anxiety (p = 0.004) improved. All participants reported perfect medication compliance (100%). Satisfaction with the app was high. Conclusions: This mobile app-based rehabilitation program demonstrated good feasibility, with satisfactory recruitment, adherence, and safety, providing valuable insights into future definitive studies.
C1 [Chan, Wing-Lok; Tai, Yin-Ling; Liu, Michelle; Yun, Bryan; Zhang, Yuning; Hou, Holly Li-Yu; Kwong, Dora; Lee, Victor Ho-Fun] Univ Hong Kong, LKS Fac Med, Sch Clin Med, Dept Clin Oncol, Hong Kong, Peoples R China.
   [Wong, Yat-Lam] Queen Mary Hosp, Dept Clin Oncol, Hong Kong, Peoples R China.
   [Lam, Wendy Wing-Tak] Univ Hong Kong, LKS Fac Med, Sch Publ Hlth, Hong Kong, Peoples R China.
C3 University of Hong Kong; University of Hong Kong; University of Hong
   Kong
RP Chan, WL (corresponding author), Univ Hong Kong, LKS Fac Med, Sch Clin Med, Dept Clin Oncol, Hong Kong, Peoples R China.
EM winglok@hku.hk; wyl813@ha.org.hk; et1510@hku.hk; yuningz@hku.hk;
   hollyhou@hku.hk; dlwkwong@hku.hk; vhflee@hku.hk; wwtlam@hku.hk
RI Lee, Victor/I-3554-2015; /C-4295-2009; Lam, Wendy Wing Tak/C-4319-2009
OI /0000-0002-1304-2854; Lam, Wendy Wing Tak/0000-0003-2383-0149; Chan,
   Wing Lok/0000-0001-9793-9273; Lee, Victor/0000-0002-6283-978X
FU Pfizer Breast Cancer Competitive Research Grant Program for Africa, the
   Middle East, Asia, and Latin America Regions in 2020 [60555419]; Pfizer
   Breast Cancer Competitive Research Grant Program for Africa
FX This research was funded by the Pfizer Breast Cancer Competitive
   Research Grant Program for Africa, the Middle East, Asia, and Latin
   America Regions in 2020 (Funding Number: 60555419).
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NR 28
TC 0
Z9 0
U1 2
U2 2
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6694
J9 CANCERS
JI Cancers
PD DEC
PY 2024
VL 16
IS 23
AR 4084
DI 10.3390/cancers16234084
PG 13
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA P2F4T
UT WOS:001376133600001
PM 39682269
OA gold
DA 2025-06-11
ER

PT J
AU Latif, R
   Mumtaz, S
   Al Sheikh, MH
   Chathoth, S
   Al Naimi, SN
AF Latif, Rabia
   Mumtaz, Sadaf
   Al Sheikh, Mona Hmoud
   Chathoth, Shahanas
   Al Naimi, Shaykhah Nasser
TI Effects of Turmeric on Cardiovascular Risk Factors, Mental Health, and
   Serum Homocysteine in Overweight, Obese Females
SO ALTERNATIVE THERAPIES IN HEALTH AND MEDICINE
LA English
DT Article
ID BODY-MASS INDEX; DOUBLE-BLIND; METABOLIC SYNDROME; CONTROLLED-TRIAL;
   WEIGHT-LOSS; CURCUMIN; ANTIOXIDANT; STRESS; TETRAHYDROCURCUMIN;
   HYPERTENSION
AB Context . The prevalence of overweight and obesity and associated comorbidities has progressively risen. Curcumin, the active ingredient in turmeric, and turmeric aqueous extract, a concentrated form, have been reported to have beneficial effects in treatment of cardiovascular diseases and their risk factors. However, turmeric has not been studied in its natural form.
   Objective . The present study planned to evaluate the beneficial effects of turmeric in its natural form on obesity-related, cardiovascular-disease risk factors in overweight or obese females.
   Design . The study used a pre-post, single-arm design.
   Setting . The study took place in the Department of Physiology at Imam Abdulrahman Bin Faisal University (Dammam, Saudi Arabia).
   Participants . The participants were 36 young female students at the university, with a body mass index >= 23 kg/m(2).
   Intervention . Participants received a daily dose of 2 g/d of turmeric in capsules for 90 d.
   Outcome Measures . Anthropometric measures, blood pressure, serum homocysteine, and mental health status- stress, anxiety, depression scores-were recorded at baseline and postintervention. Dietary intake and physical activity (confounding variables) were also measured.
   Results . The following anthropometric measures were reduced significantly between baseline and postintervention: (1) body weight-73.47 vs 72.45 kg (P=.04), (2) body mass index-28.75 vs 28.27 kg/m(2) (P=.02), (3) waist circumference-81.85 vs 77.96 cm (P=.01), (4) hip circumference-102.72 vs 98.10 cm (P=.001), (5) body fat %-34.34 vs 32.58 (P=.00), (6) systolic blood pressure-119.12 vs 115.92 mm Hg (P=.04), and (7) anxiety scores-7.88 vs 4.73 (P=.03), as compared by paired t test. Homocysteine levels and stress and depression scores showed no significant changes. Dietary intake and physical activity did not vary significantly throughout the study period.
   Conclusion . Turmeric has the ability to reduce weight, decrease body fat percentage, lower systolic blood pressure, and relieve anxiety for young, obese and overweight females, when given at 2 g/d for 90 d.
C1 [Latif, Rabia; Al Sheikh, Mona Hmoud; Al Naimi, Shaykhah Nasser] Imam Abdulrahman Bin Faisal Univ, Coll Med, Dept Physiol, Dammam, Saudi Arabia.
   [Mumtaz, Sadaf] Dent Coll HITEC Inst Med Sci, Dept Physiol, Rawalpindi, Pakistan.
   [Chathoth, Shahanas] Imam Abdulrahman Bin Faisal Univ, Coll Med, Dept Biochem, Dammam, Saudi Arabia.
C3 Imam Abdulrahman Bin Faisal University; Imam Abdulrahman Bin Faisal
   University
RP Latif, R (corresponding author), Imam Abdulrahman Bin Faisal Univ, Coll Med, Dept Physiol, Dammam, Saudi Arabia.
EM rlhussain@iau.edu.sa
RI CHATHOTH, SHAHANAS/A-3268-2015; Latif, Rabia/AAD-9024-2021; Sheikh,
   Mona/H-8658-2019
OI , Rabia Latif/0000-0001-6489-5809
FU Deanship of Scientific Research at Imam Abdulrahman Bin Faisal
   University [2017288-Med]
FX The authors acknowledge the financial support given by the Deanship of
   Scientific Research at Imam Abdulrahman Bin Faisal University for this
   study (grant No. 2017288-Med).
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NR 36
TC 9
Z9 9
U1 0
U2 1
PU INNOVISION COMMUNICATIONS
PI ALISO VIEJO
PA 101 COLUMBIA, ALISO VIEJO, CA 92656 USA
SN 1078-6791
J9 ALTERN THER HEALTH M
JI Altern. Ther. Health Med.
PD JUN
PY 2021
VL 27
SU 1
BP 114
EP 119
PG 6
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Integrative & Complementary Medicine
GA XQ8CT
UT WOS:000731771200015
PM 32088675
DA 2025-06-11
ER

PT J
AU Jakovjevic, M
   Crncevic, Z
   Ljubicic, D
   Babic, D
   Topic, R
   Saric, M
AF Jakovjevic, Miro
   Crncevic, Zeljka
   Ljubicic, Duliano
   Babic, Dragan
   Topic, Radmila
   Saric, Marija
TI Mental disorders and metabolic syndrome: A fatamorgana or warning
   reality?
SO PSYCHIATRIA DANUBINA
LA English
DT Review
DE metabolic syndrome; schizophrenia; schizoaffective disorder; bipolar
   disorder; major depression; post-traumatic stress syndrome; mind-body
   medicine
ID DEPRESSION; SCHIZOPHRENIA
AB Background: There has been a growing interest in the effect that comorbid mental and somatic disorders may have on each other. Metabolic syndrome is an important risk factor for the development of diabetes mellitus, cardiovascular disease and premature mortality.
   Objectives: To examine the association between various mental disorders (schizophrenia, schizoaffective disorder, bipolar disorder, depression, posttraumatic stress disorder and other mental disorders) and metabolic syndrome and discuss the possible pathophysiologic mechanisms that may link specific mental disorders and metabolic syndrome.
   Method: A MEDLINE search, citing articles from 1966 onward, supplemented by a review of bibliographies, was conducted to identify relevant studies. Criteria used to identify studies included (1) English language, (2) published studies with original data in peer-reviewed journals.
   Results: Clinical investigation of the metabolic syndrome in patients with mental disorders, except schizophrenia, has been surprisingly scarce. Metabolic syndrome was reported in 19-63% of schizophrenic patients, in 42.4% of patients with schizo-affective disorder, in 24.6-50% of bipolar patients, in 12-36% of the patients with recurrent depression and in 31.9-35% of patients with combat posttraumatic stress disorder.
   Conclusion: Metabolic syndrome can contribute to significant morbidity and premature mortality and should be accounted for in the treatment of mental disorders. No definite or reliable insight into the pathophysiological link between metabolic syndrome and mental disorders is available.
C1 [Jakovjevic, Miro; Topic, Radmila] Univ Zagreb, Clin Hosp Ctr, Univ Psychiat Clin Rebro, Zagreb 10000, Croatia.
   [Crncevic, Zeljka] Clin Hosp Ctr Rijeka, Univ Psychiat Dept, Rijeka, Croatia.
   [Ljubicic, Duliano] Clin Hosp Ctr Rijeka, Univ Edocrinol Dept, Rijeka, Croatia.
   [Babic, Dragan] Univ Mostar, Dept Psychiat, Sch Med, Mostar, Bosnia & Herceg.
   [Saric, Marija] Univ Zagreb, Childrens Hosp, Zagreb, Croatia.
C3 University of Zagreb; University of Rijeka; University of Rijeka;
   University of Mostar; University of Zagreb
RP Jakovjevic, M (corresponding author), Univ Zagreb, Clin Hosp Ctr, Univ Psychiat Clin Rebro, Kispaticeva 12, Zagreb 10000, Croatia.
EM miro.jakovljevic@mef.hr
CR [Anonymous], 2002, MED COMPLICATIONS PS
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NR 44
TC 44
Z9 47
U1 0
U2 7
PU MEDICINSKA NAKLADA
PI ZAGREB
PA VLASKA 69, HR-10000 ZAGREB, CROATIA
SN 0353-5053
J9 PSYCHIAT DANUB
JI Psychiatr. Danub.
PD JUN
PY 2007
VL 19
IS 1-2
BP 76
EP 86
PG 11
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 270GV
UT WOS:000253710100012
PM 17603420
DA 2025-06-11
ER

PT J
AU Nobre, B
   Rocha, I
   Morin, CM
   Cruz, MME
AF Nobre, Barbara
   Rocha, Isabel
   Morin, Charles M.
   Meira e Cruz, Miguel
TI Insomnia and circadian misalignment: an underexplored interaction
   towards cardiometabolic risk
SO SLEEP SCIENCE
LA English
DT Review
DE Insomnia; Circadian Misalignment; Cardiometabolic Risk; Shift-Work;
   Autonomic Nervous System
ID SHORT-SLEEP DURATION; ROTATING SHIFT WORK; CARDIOVASCULAR RISK;
   METABOLIC SYNDROME; CONSEQUENCES; IMPACT; RHYTHM; QUALITY; STRESS;
   HEALTH
AB Insomnia remains the most prevalent sleep disorder worldwide, and its pathophysiology suggests an interface with circadian rhythm sleep-wake disorders (CRSWDs). Some epidemiological studies have linked insomnia and circadian misalignment with adverse cardiometabolic outcomes, but the mechanisms underlying this relationship are still unclear. The autonomic nervous system (ANS) has been pointed out as a crucial/key mediator that triggers cardiometabolic risk. Therefore, a critical review of the literature focused on the past ten years was conducted to highlight the relationship between insomnia, circadian misalignment and cardiometabolic risk, with particular emphasis on the influence of the ANS. Shift work, as a model of circadian misalignment, was shown to increase both cardiovascular and metabolic risk and so may integrate a proof of concept on this link. Furthermore, there is good evidence from previous studies supporting that cardiac autonomic dysfunction is indeed a possible mechanism that potentiates cardiometabolic risk in insomniacs and individuals with a misalignment of the circadian timing system (e.g., shift workers), via changes in autonomic variables. Further research is however required in order to definitively establish this interactive relationship.
C1 [Nobre, Barbara; Meira e Cruz, Miguel] Univ Lisbon, Lisbon Sch Med, Sleep Unit, Ctr Cardiovasc, Lisbon, Portugal.
   [Rocha, Isabel] Univ Lisbon, Lisbon Sch Med, Cardiovasc Auton Funct Lab, Ctr Cardiovasc, Lisbon, Portugal.
   [Morin, Charles M.] Laval Univ, Psychol, Quebec City, PQ, Canada.
   [Meira e Cruz, Miguel] Fac Sao Leopoldo Mandic, Lab Neuroimmune Interface Pain Res, Campinas, SP, Brazil.
C3 Universidade de Lisboa; Universidade de Lisboa; Laval University;
   Faculdade Sao Leopoldo Mandic
RP Cruz, MME (corresponding author), Univ Lisbon, Lisbon Sch Med, Sleep Unit, Ctr Cardiovasc, Lisbon, Portugal.; Cruz, MME (corresponding author), Fac Sao Leopoldo Mandic, Lab Neuroimmune Interface Pain Res, Campinas, SP, Brazil.
EM mcruz@medicina.ulisboa.pt
RI Meira e Cruz, Miguel/AAS-3687-2020; Rocha, Isabel/A-4279-2013
OI rocha, isabel/0000-0002-7582-0893
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NR 82
TC 11
Z9 11
U1 0
U2 7
PU THIEME MEDICAL PUBL INC
PI NEW YORK
PA 333 SEVENTH AVE, NEW YORK, NY 10001 USA
SN 1984-0659
EI 1984-0063
J9 SLEEP SCI
JI Sleep Sci.
PY 2021
VL 14
IS 1
BP 55
EP 63
DI 10.5935/1984-0063.20200025
PG 9
WC Clinical Neurology
WE Emerging Sources Citation Index (ESCI)
SC Neurosciences & Neurology
GA QX5WD
UT WOS:000629416500009
PM 34104338
DA 2025-06-11
ER

PT J
AU Renugasundari, M
   Pal, GK
   Chaturvedula, L
   Nanda, N
   Harichandrakumar, KT
   Durgadevi, T
AF Renugasundari, Manoharan
   Pal, Gopal Krushna
   Chaturvedula, Latha
   Nanda, Nivedita
   Harichandrakumar, K. T.
   Durgadevi, Thiyagarajan
TI Inflammation and decreased cardiovagal modulation are linked to stress
   and depression at 36th week of pregnancy in gestational diabetes
   mellitus
SO SCIENTIFIC REPORTS
LA English
DT Article
ID QUALITY-OF-LIFE; HEART-RATE-VARIABILITY; SYMPATHOVAGAL IMBALANCE;
   CARDIOVASCULAR RISK; BAROREFLEX SENSITIVITY; METABOLIC SYNDROME;
   SPECTRAL-ANALYSIS; ASSOCIATION; WOMEN; POSTPARTUM
AB Stress and depression have been reported in gestational diabetes mellitus (GDM). Though inflammation and oxidative stress are associated with depression, there are no reports of link of cardiometabolic risks (CMR) to stress and depression in GDM. Normal pregnant women (control group, n=164) and women with GDM (study group, n=176) at 36th week of gestation were recruited for the study. Blood pressure (BP), body composition, heart rate variability (HRV), glycated hemoglobin (HbA1C), markers of insulin resistance, oxidative stress, inflammation and endothelial dysfunction, were assessed. Perceived stress score (PSS), quality of life (QoL) scale, Indian diabetic risk score (IDRS) and Edinburg postnatal depression score (EPDS) were assessed. Association of potential contributors to PSS and EDPS were assessed by correlation and regression analyses. There was significant increase in PSS, EPDS, IDRS scores, HbA1C, malondialdehyde (MDA) (oxidative stress marker) and high-sensitive C-reactive protein and interleukin-6 (inflammatory markers), and significant decrease in total power (TP) of HRV (marker of cardiovagal modulation), QoL and nitric oxide (endothelial dysfunction marker) in study group compared to control group. Though many cardiometabolic risk parameters were correlated with PSS and EPDS, the significant independent association was observed for TP, HbA1C, MDA and interleukin-6. However, interleukin-6 had maximum contribution to PSS (beta=0.550, p<0.001) and EPDS (beta=0.393, p<0.001) as demonstrated by multiple regression analysis. Inflammation, oxidative stress, glycation status and decreased cardiovagal modulation are associated with stress and depression at 36th week of gestation in GDM.
C1 [Renugasundari, Manoharan] JIPMER, Dept Physiol, Pondicherry, India.
   [Pal, Gopal Krushna] AIIMS, Patna, Bihar, India.
   [Chaturvedula, Latha] JIPMER, Dept Obstet & Gynecol, Pondicherry, India.
   [Nanda, Nivedita; Durgadevi, Thiyagarajan] JIPMER, Dept Biochem, Pondicherry, India.
   [Harichandrakumar, K. T.] JIPMER, Dept Biostat, Pondicherry, India.
C3 Jawaharlal Institute of Postgraduate Medical Education & Research; All
   India Institute of Medical Sciences (AIIMS) Patna; Jawaharlal Institute
   of Postgraduate Medical Education & Research; Jawaharlal Institute of
   Postgraduate Medical Education & Research; Jawaharlal Institute of
   Postgraduate Medical Education & Research
RP Pal, GK (corresponding author), AIIMS, Patna, Bihar, India.
EM drgkpal@gmail.com
RI Chaturvedula, Latha/AAN-1332-2021; Nanda, Nivedita/P-6453-2014
FU JIPMER Authority
FX Authors acknowledge the support given by JIPMER Authority to the first
   author as part of her PhD intramural grant, for conduct of this study.
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NR 73
TC 5
Z9 5
U1 0
U2 1
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD JUN 26
PY 2023
VL 13
IS 1
AR 10348
DI 10.1038/s41598-023-37387-4
PG 15
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA Q7CI4
UT WOS:001059061400050
PM 37365247
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Lamers, F
   Milaneschi, Y
   de Jonge, P
   Giltay, EJ
   Penninx, BWJH
AF Lamers, F.
   Milaneschi, Y.
   de Jonge, P.
   Giltay, E. J.
   Penninx, B. W. J. H.
TI Metabolic and inflammatory markers: associations with individual
   depressive symptoms
SO PSYCHOLOGICAL MEDICINE
LA English
DT Article
DE Atypical depression; BMI; depressive disorder; inflammation; metabolic
   syndrome; symptoms
ID OBSTRUCTIVE SLEEP-APNEA; C-REACTIVE PROTEIN; MAJOR DEPRESSION; ATYPICAL
   FEATURES; CLINICAL-TRIAL; ANXIETY NESDA; DISORDER; METAANALYSIS;
   OBESITY; POPULATION
AB Background. Literature has shown that obesity, metabolic syndrome and inflammation are associated with depression, however, evidence suggests that these associations are specific to atypical depression. Which of the atypical symptoms are driving associations with obesity-related outcomes and inflammation is unknown. We evaluated associations between individual symptoms of depression (both atypical and non-atypical) and body mass index (BMI), metabolic syndrome components and inflammatory markers.
   Methods. We included 808 persons with a current diagnosis of depression participating in the Netherlands Study of Depression and Anxiety (67% female, mean age 41.6 years). Depressive symptoms were derived from the Composite International Diagnostic Interview and the Inventory of Depressive Symptomatology. Univariable and multivariable regression analyses adjusting for sex, age, educational level, depression severity, current smoking, physical activity, anti-inflammatory medication use, and statin use were performed.
   Results. Increased appetite was positively associated with BMI, number of metabolic syndrome components, waist circumference, C-reactive protein and tumor necrosis factor-a. Decreased appetite was negatively associated with BMI and waist circumference. Psychomotor retardation was positively associated with BMI, high-density lipoprotein cholesterol and triglycerides, and insomnia with number of metabolic syndrome components.
   Conclusion. Increased appetite - in the context of a depressive episode - was the only symptom that was associated with both metabolic as well as inflammatory markers, and could be a key feature of an immuno-metabolic form of depression. This immuno-metabolic depression should be considered in clinical trials evaluating effectiveness of compounds targeting metabolic and inflammatory pathways or lifestyle interventions.
C1 [Lamers, F.; Milaneschi, Y.; Penninx, B. W. J. H.] Vrije Univ Amsterdam, Med Ctr GGZ InGeest, Amsterdam Publ Hlth Res Inst, Dept Psychiat, Amsterdam, Netherlands.
   [Lamers, F.; Milaneschi, Y.; Penninx, B. W. J. H.] Vrije Univ Amsterdam, Med Ctr GGZ InGeest, Amsterdam Neurosci Res Inst, Amsterdam, Netherlands.
   [de Jonge, P.] Univ Groningen, Univ Med Ctr, Interdisciplinary Ctr Psychopathol & Emot Regulat, Groningen, Netherlands.
   [Giltay, E. J.] Leiden Univ, Med Ctr, Dept Psychiat, Leiden, Netherlands.
C3 Vrije Universiteit Amsterdam; Vrije Universiteit Amsterdam; University
   of Groningen; Leiden University - Excl LUMC; Leiden University; Leiden
   University Medical Center (LUMC)
RP Lamers, F (corresponding author), Vrije Univ Amsterdam, Med Ctr GGZ InGeest, Amsterdam Publ Hlth Res Inst, Dept Psychiat, Amsterdam, Netherlands.; Lamers, F (corresponding author), Vrije Univ Amsterdam, Med Ctr GGZ InGeest, Amsterdam Neurosci Res Inst, Amsterdam, Netherlands.
EM f.lamers@vumc.nl
RI Lamers, Femke/G-5161-2012; Giltay, Erik/AAL-9948-2021; Penninx,
   Brenda/S-7627-2017; de Jonge, Peter/L-6395-2013
OI de Jonge, Peter/0000-0002-0866-6929; Milaneschi,
   Yuri/0000-0002-3697-6617; Lamers, Femke/0000-0003-4344-5766; Giltay,
   Erik J./0000-0001-8874-2292
FU Geestkracht program of the Netherlands Organisation for Health Research
   and Development (Zon-Mw) [10-000-1002]; European Union Seventh Framework
   Programme (FP7) [PCIG12-GA-2012-334065]; VICI grant (Netherlands
   Organisation for Health Research and Development) [91812607]; VU
   University Medical Center; Leiden University Medical Center; University
   Medical Center Groningen
FX The infrastructure for the NESDA study (www.nesda.nl) has been funded
   through the Geestkracht program of the Netherlands Organisation for
   Health Research and Development (Zon-Mw, grant number 10-000-1002) and
   participating universities (VU University Medical Center, Leiden
   University Medical Center, University Medical Center Groningen). FL has
   received funding from the European Union Seventh Framework Programme
   (FP7/2007-2013) under grant agreement no PCIG12-GA-2012-334065. PdJ was
   supported by a VICI grant (Netherlands Organisation for Health Research
   and Development; no 91812607, deconstructing depression).
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NR 57
TC 142
Z9 147
U1 0
U2 21
PU CAMBRIDGE UNIV PRESS
PI NEW YORK
PA 32 AVENUE OF THE AMERICAS, NEW YORK, NY 10013-2473 USA
SN 0033-2917
EI 1469-8978
J9 PSYCHOL MED
JI Psychol. Med.
PD MAY
PY 2018
VL 48
IS 7
BP 1102
EP 1110
DI 10.1017/S0033291717002483
PG 9
WC Psychology, Clinical; Psychiatry; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA GC9RL
UT WOS:000430136400005
PM 28889804
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Aparicio, VA
   Marín-Jiménez, N
   Coll-Risco, I
   de la Flor-Alemany, M
   Baena-García, L
   Acosta-Manzano, P
   Aranda, P
AF Aparicio, Virginia A.
   Marin-Jimenez, Nuria
   Coll-Risco, Irene
   de la Flor-Alemany, Marta
   Baena-Garcia, Laura
   Acosta-Manzano, Pedro
   Aranda, Pilar
TI Doctor, ask your perimenopausal patient about her physical fitness;
   association of self-reported physical fitness with cardiometabolic and
   mental health in perimenopausal women: the FLAMENCO project
SO MENOPAUSE-THE JOURNAL OF THE MENOPAUSE SOCIETY
LA English
DT Article
DE Anxiety; Body composition; Cardiovascular disease; Depression;
   International fitness scale; Positive health
ID CARDIOVASCULAR-DISEASE RISK; MAJOR DEPRESSIVE DISORDER; TEST-RETEST
   RELIABILITY; CARDIORESPIRATORY FITNESS; SCALE IFIS; CONSTRUCT-VALIDITY;
   BLOOD-PRESSURE; METABOLIC SYNDROME; CARE COSTS; EXERCISE
AB Objective: The aim of this study was to explore the association of self-reported physical fitness (PF) and its components with cardiometabolic and mental health in perimenopausal women. Methods: These cross-sectional analyses included 191 participants (53 +/- 4 y old) from the FLAMENCO project. Self-reported PF was assessed with the International Fitness Scale (IFIS). Body mass index (BMI), fat mass (FM), waist circumference (WC), systolic and diastolic blood pressure (DBP), high-density lipoprotein cholesterol (HDL-C), triglycerides, C-reactive protein (CRP), and glucose were measured. The Beck's Depression Inventory, State-Trait Anxiety Inventory, Pittsburgh Sleep Quality Index, Life Orientation Test Revised, and Positive and Negative Affect Schedule were used to assess mental health. Results: After adjusting for potential confounders, greater overall PF was associated with lower BMI, FM, WC (P < 0.001), DBP and CRP, and higher HDL-C (P < 0.05). Cardiorespiratory fitness (CRF), speed-agility, and flexibility were associated with lower BMI, WC, and FM (P < 0.001), and muscle strength (MS) with lower WC and FM (P < 0.05). In addition, CRF, MS, and speed-agility were associated with lower CRP (P < 0.01), and flexibility with enhanced triglycerides and HDL-C (P < 0.05). Overall PF and all its components were associated with lower depression, anxiety, and negative affect (P <= 0.01), and greater positive affect (P <= 0.05). Overall PF and MS were associated with better sleep quality (P < 0.05), and CRF, MS, and speed-agility with greater optimism (P <= 0.05). Finally, overall PF showed evidence of significant association with less pharmaceutical expenditure (B = -7.2, beta=-0.145, P = 0.08). Conclusions: Self-reported PF was associated with better cardiometabolic and mental health in perimenopausal women. The IFIS might be proposed as an inexpensive, quick, and easy tool in clinical settings.
C1 [Aparicio, Virginia A.; Coll-Risco, Irene; de la Flor-Alemany, Marta; Aranda, Pilar] Univ Granada, Biomed Res Ctr, Inst Nutr & Food Technol, Dept Physiol, Granada, Spain.
   [Aparicio, Virginia A.; Marin-Jimenez, Nuria; Coll-Risco, Irene; de la Flor-Alemany, Marta; Acosta-Manzano, Pedro; Aranda, Pilar] Univ Granada, Sport & Hlth Univ Res Inst iMUDS, Granada, Spain.
   [Marin-Jimenez, Nuria; Acosta-Manzano, Pedro] Univ Granada, Fac Sport Sci, Dept Phys Educ & Sport, Granada, Spain.
   [Baena-Garcia, Laura] Univ Granada, Dept Nursing, Fac Hlth Sci, Granada, Spain.
C3 University of Granada; University of Granada; University of Granada;
   University of Granada
RP Aparicio, VA (corresponding author), Sch Pharm, Dept Physiol, Campus Univ Cartuja S-N, Granada 18071, Spain.
EM virginiaparicio@ugr.es
RI Coll Risco, Irene/GZN-1623-2022; Marin-Jimenez, Nuria/HMP-5009-2023; De
   La Flor Alemany, Marta/AFT-1666-2022; Baena-García, Laura/AAR-2350-2021;
   Aparicio, Virginia A/D-9666-2016; Aranda Ramirez, Pilar/B-8037-2016
OI BAENA GARCIA, LAURA/0000-0002-4895-567X; Aparicio, Virginia
   A/0000-0002-2867-378X; Coll-Risco, Irene/0000-0003-2176-0538; De La Flor
   Alemany, Marta/0000-0001-8256-5053; Aranda Ramirez,
   Pilar/0000-0002-7982-1359
FU Ministry of Health of the Junta de Andalucia, Spain [PI-0667-2013];
   Spanish Ministry of Education, Culture and Sport [FPU17/03715];
   University of Granada, Plan Propio de Investigacion 2016, Unit of
   Excellence on Exercise and Health; Junta de Andalucia; Consejeria de
   Conocimiento, Investigacion y Universidades; European Regional
   Development Fund [SOMM17/6107/UGR]
FX This study was supported by the project PI-0667-2013, funded by the
   Ministry of Health of the Junta de Andalucia, Spain. This study has been
   also partially funded by the Spanish Ministry of Education, Culture and
   Sport (FPU17/03715), by the University of Granada, Plan Propio de
   Investigacion 2016, Unit of Excellence on Exercise and Health, and by
   the Junta de Andalucia, Consejeria de Conocimiento, Investigacion y
   Universidades and European Regional Development Fund, ref.
   SOMM17/6107/UGR.
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NR 58
TC 16
Z9 17
U1 1
U2 18
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 1072-3714
EI 1530-0374
J9 MENOPAUSE
JI Menopause-J. Menopause Soc..
PD OCT
PY 2019
VL 26
IS 10
BP 1146
EP 1153
DI 10.1097/GME.0000000000001384
PG 8
WC Obstetrics & Gynecology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Obstetrics & Gynecology
GA KC0FJ
UT WOS:000506862200011
PM 31513090
OA Green Submitted
DA 2025-06-11
ER

PT J
AU Smith, GD
   Ben-Shlomo, Y
   Beswick, A
   Yarnell, J
   Lightman, S
   Elwood, P
AF Smith, GD
   Ben-Shlomo, Y
   Beswick, A
   Yarnell, J
   Lightman, S
   Elwood, P
TI Cortisol, testosterone, and coronary heart disease - Prospective
   evidence from the Caerphilly study
SO CIRCULATION
LA English
DT Article
DE heart diseases; hormones; stress
ID STRESS-INDUCED SUPPRESSION; ELEVATED PLASMA-CORTISOL; BLOOD-PRESSURE
   REACTIONS; PSYCHOLOGICAL STRESS; ARTERY-DISEASE; INSULIN-RESISTANCE;
   BIOLOGICAL BASIS; SERUM CORTISOL; RISK-FACTORS; T/C RATIO
AB Background - There is a popular belief that chronic stress causes heart disease through psychoneuroendocrine mechanisms. We have examined whether an elevated circulating cortisol-to-testosterone ratio increases the risk of ischemic heart disease.
   Methods and Results - We undertook a prospective cohort study of 2512 men aged 45 to 59 years between 1979 and 1983 from Caerphilly, South Wales, with a mean follow-up of 16.5 years. Subjects underwent a clinical examination, and morning fasting blood samples were taken for analysis of cortisol levels, testosterone levels, and other cardiovascular risk factors. The ratio of cortisol to testosterone showed weak associations with potential confounding factors but strong positive associations with components of the insulin resistance syndrome ( P < 0.001). A positive linear trend was seen across quintiles of cortisol: testosterone ratio for incident ischemic heart disease (age-adjusted OR per z score change in ratio 1.22, 95% CI 1.07 to 1.38, P = 0.003). This was markedly attenuated after adjustment for components of the insulin resistance syndrome ( age-adjusted OR per z score change in ratio 1.10, 95% CI 0.96 to 1.25, P = 0.18). There was no association between the cortisol: testosterone ratio and other causes of death ( age-adjusted hazard ratio 0.99, 95% CI 0.88 to 1.11, P = 0.81).
   Conclusions - This is the first population-based prospective study that has found a specific association between cortisol: testosterone ratio and incident ischemic heart disease, apparently mediated through the insulin resistance syndrome. Whether this reflects the effects of chronic stress, behavioral factors, or genetic influences remains to be determined.
C1 Univ Bristol, Dept Social Med, Bristol BS8 2PR, Avon, England.
   Queens Univ Belfast, Dept Epidemiol & Publ Hlth Med, Belfast, Antrim, North Ireland.
   Henry Wellcome Labs Integrat Neurosci & Endocrino, Bristol, Avon, England.
C3 University of Bristol; Queens University Belfast; University of Bristol
RP Univ Bristol, Dept Social Med, Canynge Hall,Whiteladies Rd, Bristol BS8 2PR, Avon, England.
RI Ben-Shlomo, Yoav/ABD-2004-2021; Lightman, Stafford/G-2107-2011; Davey
   Smith, George/A-7407-2013
OI Lightman, Stafford/0000-0002-8546-9646; Davey Smith,
   George/0000-0002-1407-8314; Venkatasubramanian,
   Siddharth/0000-0002-5860-0768; Ben-Shlomo, Yoav/0000-0001-6648-3007; s,
   hema/0000-0002-3440-9475; Beswick, Andrew/0000-0002-7032-7514
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NR 67
TC 257
Z9 276
U1 0
U2 24
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0009-7322
EI 1524-4539
J9 CIRCULATION
JI Circulation
PD JUL 19
PY 2005
VL 112
IS 3
BP 332
EP 340
DI 10.1161/CIRCULATIONAHA.104.489088
PG 9
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Cardiovascular System & Cardiology
GA 946UC
UT WOS:000230597600007
PM 16009799
OA Bronze
DA 2025-06-11
ER

PT J
AU Ahola, AJ
   Thorn, LM
   Saraheimo, M
   Forsblom, C
   Groop, PH
AF Ahola, Aila J.
   Thorn, Lena M.
   Saraheimo, Markku
   Forsblom, Carol
   Groop, Per-Henrik
CA Finndiane Study Grp
TI Depression is associated with the metabolic syndrome among patients with
   type 1 diabetes
SO ANNALS OF MEDICINE
LA English
DT Article
DE Depression; metabolic syndrome; type 1 diabetes
ID RISK; PREVALENCE; MORTALITY; ANXIETY; ADULTS; METAANALYSIS; NEPHROPATHY;
   POPULATION; DISORDERS; INVENTORY
AB Background. Both depression and the metabolic syndrome are frequently found among patients with type 1 diabetes, but their potential association has not yet been investigated. In this paper the relationship between depression and the metabolic syndrome among patients with type 1 diabetes was evaluated.
   Methods. A total of 1226 patients participating in the Finnish Diabetic Nephropathy Study between 2003 and 2009 were included. Depression was defined as use of antidepressive medication or Beck Depression Inventory (BDI) score >= 16. The metabolic syndrome was defined using the criteria established by the International Diabetes Federation Task Force on Epidemiology and Prevention (IDF); National Heart, Lung, and Blood Institute (NHLBI); American Heart Association (AHA); World Heart Federation (WHF); International Atherosclerosis Society (IAS); and International Association for the Study of Obesity (IASO).
   Results. The metabolic syndrome was more frequently observed among depressed patients (57% versus 46%, P = 0.008). Of the individual components of the metabolic syndrome, waist, triglyceride, and HDL components were more frequently fulfilled among patients with depression. The BDI score increased with the number of components of the metabolic syndrome present. The BDI score was independently associated with the waist component (odds ratio 1.03, 95% confidence interval 1.01-1.05) when adjusted for gender, age, socio-economic status, smoking, nephropathy, and HbA<SU1c</SU.
   Conclusion. The metabolic syndrome is frequently found among depressed patients with type 1 diabetes. Whether this association influences the development of diabetic complications is not known.
C1 [Ahola, Aila J.; Thorn, Lena M.; Saraheimo, Markku; Forsblom, Carol; Groop, Per-Henrik] Helsinki Univ Cent Hosp, Div Nephrol, Dept Med, Helsinki, Finland.
   [Ahola, Aila J.] Univ Helsinki, Dept Appl Chem & Microbiol, Div Nutr, FIN-00014 Helsinki, Finland.
   [Ahola, Aila J.; Thorn, Lena M.; Saraheimo, Markku; Forsblom, Carol; Groop, Per-Henrik] Biomedicum Helsinki, Folkhalsan Res Ctr, Folkhalsan Inst Genet, Helsinki, Finland.
C3 University of Helsinki; Helsinki University Central Hospital; University
   of Helsinki; University of Helsinki; Folkhalsan Research Center
RP Groop, PH (corresponding author), Univ Helsinki, Folkhalsan Res Ctr, Biomedicum Helsinki C318B, POB 63, FIN-00014 Helsinki, Finland.
EM per-henrik.groop@helsinki.fi
OI Rosengard-Barlund, Milla/0000-0001-5469-3517; Lakka,
   Timo/0000-0002-9199-2871; THORN, LENA/0000-0003-3999-0390; Groop,
   Per-Henrik/0000-0003-4055-6954
FU Signe and Ane Gyllenberg Foundation; Folkhalsan Research Foundation;
   Wilhelm and Else Stockmann Foundation
FX This study was supported by grants from the Signe and Ane Gyllenberg
   Foundation, Folkhalsan Research Foundation, and Wilhelm and Else
   Stockmann Foundation. The skilled technical assistance of Anna Sandelin,
   Jaana Tuomikangas, Valma Harjutsalo, and Jessica Thorn is gratefully
   acknowledged. Finally, the authors acknowledge all the physicians and
   nurses at each center participating in the collection of patients
   (online appendix).
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NR 28
TC 31
Z9 32
U1 0
U2 5
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0785-3890
EI 1365-2060
J9 ANN MED
JI Ann. Med.
PD OCT
PY 2010
VL 42
IS 7
BP 495
EP 501
DI 10.3109/07853890.2010.503660
PG 7
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 659NR
UT WOS:000282574500003
PM 20653460
OA Bronze
DA 2025-06-11
ER

PT J
AU Munguia-Izquierdo, D
   Mayolas-Pi, C
   Peñarrubia-Lozano, C
   Paris-Garcia, F
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   Oviedo-Caro, MA
   Legaz-Arrese, A
AF Munguia-Izquierdo, Diego
   Mayolas-Pi, Carmen
   Penarrubia-Lozano, Carlos
   Paris-Garcia, Federico
   Bueno-Antequera, Javier
   Angel Oviedo-Caro, Miguel
   Legaz-Arrese, Alejandro
TI Effects of Adolescent Sport Practice on Health Outcomes of Adult Amateur
   Endurance Cyclists: Adulthood Is Not Too Late to Start
SO JOURNAL OF PHYSICAL ACTIVITY & HEALTH
LA English
DT Article
DE exercise; physical activity; physical performance
ID PHYSICAL-ACTIVITY INTERVENTION; CARDIOVASCULAR RISK; SUBCLINICAL
   ATHEROSCLEROSIS; DEPRESSIVE SYMPTOMS; METABOLIC SYNDROME; HOSPITAL
   ANXIETY; BODY-COMPOSITION; LOWER PREVALENCE; PARTICIPATION; FITNESS
AB Background: We investigated the effects of adolescent sport practice on the training, performance, and health outcomes of adult amateur endurance cyclists and compared health outcomes of 3 adult groups: amateur endurance cyclists who practiced sports during adolescence, amateur endurance cyclists who did not practice sports during adolescence, and inactive individuals. Methods: In 859 (751 men and 108 women) adult cyclists and 718 inactive subjects (307 men and 411 women), we examined adolescent sport practice, current training status, quality of life, quality of sleep, anxiety and depression, and cardiometabolic risk: body mass index, physical activity, physical fitness, adherence to Mediterranean diet, and alcohol and tobacco consumption. Results: Independent of gender, no significant differences in training, performance, or health outcomes were observed between amateur endurance cyclists who practiced sports during adolescence and those who did not. Independent of gender, cyclists reported significantly better health outcomes than inactive individuals in all variables, except depression. Conclusions: Training, performance, and health outcomes did not differ between adult amateur endurance cyclists who practiced sports during adolescence and those who did not, but their health outcomes were significantly improved compared with inactive individuals, except for depression.
C1 [Munguia-Izquierdo, Diego; Paris-Garcia, Federico; Bueno-Antequera, Javier; Angel Oviedo-Caro, Miguel] Univ Pablo de Olavide, Dept Sports & Comp Sci, Sect Phys Educ & Sports, Fac Sports Sci, Seville, Spain.
   [Munguia-Izquierdo, Diego] Biomed Res Networking Ctr Frailty & Hlth Aging, Madrid, Spain.
   [Mayolas-Pi, Carmen; Legaz-Arrese, Alejandro] Univ Zaragoza, Dept Physiatry & Nursery, Sect Phys Educ & Sports, Fac Hlth & Sport Sci, Zaragoza, Spain.
   [Penarrubia-Lozano, Carlos] Univ Zaragoza, Dept Mus Plast & Body Express, Fac Educ Sci, Zaragoza, Spain.
C3 Universidad Pablo de Olavide; University of Zaragoza; University of
   Zaragoza
RP Paris-Garcia, F (corresponding author), Univ Pablo de Olavide, Dept Sports & Comp Sci, Sect Phys Educ & Sports, Fac Sports Sci, Seville, Spain.
EM fparis@upo.es
RI Oviedo-Caro, Miguel/AAT-6933-2020; Mayolas-Pi, Carmen/Y-2652-2018;
   Peñarrubia-Lozano, Carlos/L-7068-2018; Munguía-Izquierdo,
   Diego/H-6452-2013; Bueno-Antequera, Javier/H-5515-2015; PARIS-GARCIA,
   FEDERICO/F-6853-2016; Legaz Arrese, Alejandro/H-8702-2013
OI Munguia Izquierdo, Diego/0000-0001-7817-747X; Penarrubia Lozano,
   Carlos/0000-0002-3776-2901; Bueno-Antequera, Javier/0000-0001-8063-3980;
   Oviedo-Caro, Miguel Angel/0000-0003-1032-0529; PARIS-GARCIA,
   FEDERICO/0000-0002-7440-5719; Mayolas Pi, Carmen/0000-0003-0721-2447;
   Legaz Arrese, Alejandro/0000-0003-2644-9386
FU University of Zaragoza, Spain [UZ2016-BIO-03, 216163/3]; research group
   B62-Movimiento Humano; Spanish Ministry of Education, Culture and Sport
   [FPU13/05130]; European University of Madrid, Catedra Real Madrid, Spain
   [P2016/19RM]
FX The authors gratefully acknowledge all the subjects who participated in
   this study. This study was supported by the University of Zaragoza,
   Spain (funding project no. UZ2016-BIO-03), research group B62-Movimiento
   Humano, University of Zaragoza, Spain (grant no. 216163/3), Spanish
   Ministry of Education, Culture and Sport (grant no. FPU13/05130), and
   European University of Madrid, Catedra Real Madrid, Spain (funding
   project no. P2016/19RM). All authors declare that they have no conflict
   of interest of any kind.
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NR 46
TC 13
Z9 13
U1 2
U2 27
PU HUMAN KINETICS PUBL INC
PI CHAMPAIGN
PA 1607 N MARKET ST, PO BOX 5076, CHAMPAIGN, IL 61820-2200 USA
SN 1543-3080
EI 1543-5474
J9 J PHYS ACT HEALTH
JI J. Phys. Act. Health
PD NOV
PY 2017
VL 14
IS 11
BP 876
EP 882
DI 10.1123/jpah.2017-0010
PG 7
WC Public, Environmental & Occupational Health
WE Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA FM4OX
UT WOS:000414999500006
PM 28556687
DA 2025-06-11
ER

PT J
AU Dortland, AKBV
   Vreeburg, SA
   Giltay, EJ
   Licht, CMM
   Vogelzangs, N
   van Veen, T
   de Geus, EJC
   Penninx, BWJH
   Zitman, FG
AF Dortland, Arianne K. B. van Reedt
   Vreeburg, Sophie A.
   Giltay, Erik J.
   Licht, Carmilla M. M.
   Vogelzangs, Nicole
   van Veen, Tineke
   de Geus, Eco J. C.
   Penninx, Brenda W. J. H.
   Zitman, Frans G.
TI The impact of stress systems and lifestyle on dyslipidemia and obesity
   in anxiety and depression
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE Anxiety; Depression; Tricyclic antidepressants; HPA axis; Autonomic
   nervous system; Inflammation; Lifestyle
ID CORONARY-HEART-DISEASE; C-REACTIVE PROTEIN; METABOLIC SYNDROME; SALIVARY
   CORTISOL; MAJOR DEPRESSION; FOLLOW-UP; ANTIDEPRESSANT USE;
   RATE-VARIABILITY; SLEEP DURATION; ADRENAL AXIS
AB Background: Dyslipidemia and obesity have been observed in persons with severe anxiety or depression, and in tricyclic antidepressant (TCA) users. This likely contributes to the higher risk of cardiovascular disease (CVD) in anxiety and depressive disorders. We aimed to elucidate whether biological stress systems or lifestyle factors underlie these associations. If so, they may be useful targets for CVD prevention and intervention.
   Methods: Within 2850 Netherlands Study of Depression and Anxiety (NESDA) participants, we evaluated the explaining impact of biological stress systems (i.e., the hypothalamic-pituitary- adrenal [HPA] axis, autonomic nervous system [ANS] and inflammation) and lifestyle factors (i.e., tobacco and alcohol use, and physical activity) on adverse associations of anxiety and depression severity and TCA use with high and low-density lipoprotein cholesterol, triglycerides, body mass index and waist circumference. Through linear regression analyses, percentual change (%Delta) in beta was determined and considered significant when %Delta > 10.
   Results: The inflammatory marker C-reactive protein had the most consistent impact (explaining 14-53% of the associations of anxiety and depression severity and TCA use with lipid and obesity levels), followed by tobacco use (explaining 34-43% of the associations with lipids). The ANS mediated all associations with TCA use (explaining 32-61%). The HPA axis measures did not explain any of the associations.
   Conclusions: Increased dyslipidemia and (abdominal) obesity risk in patients with more severe anxiety disorders and depression may be partly explained by chronic low-grade inflammation and smoking. TCAs may increase metabolic risk through enhanced sympathetic and decreased parasympathetic ANS activity. That the HPA axis had no impact in our sample may reflect the possibility that the HPA axis only plays a role in acute stress situations rather than under basal conditions. (C) 2012 Elsevier Ltd. All rights reserved.
C1 [Dortland, Arianne K. B. van Reedt; Giltay, Erik J.; van Veen, Tineke; Penninx, Brenda W. J. H.; Zitman, Frans G.] Leiden Univ, Med Ctr, Dept Psychiat, POB 9600, NL-2300 RC Leiden, Netherlands.
   [Vreeburg, Sophie A.; Licht, Carmilla M. M.; Vogelzangs, Nicole; de Geus, Eco J. C.; Penninx, Brenda W. J. H.] Vrije Univ Amsterdam, Med Ctr, Dept Psychiat, Amsterdam, Netherlands.
   [Vreeburg, Sophie A.; Licht, Carmilla M. M.; Vogelzangs, Nicole; de Geus, Eco J. C.; Penninx, Brenda W. J. H.] Vrije Univ Amsterdam, Med Ctr, EMGO Inst Hlth & Care Res, Amsterdam, Netherlands.
   [Penninx, Brenda W. J. H.] Univ Groningen, Univ Med Ctr Groningen, Dept Psychiat, NL-9713 AV Groningen, Netherlands.
   [de Geus, Eco J. C.] Vrije Univ Amsterdam, Dept Biol Psychol, Amsterdam, Netherlands.
C3 Leiden University; Leiden University Medical Center (LUMC); Leiden
   University - Excl LUMC; Vrije Universiteit Amsterdam; Vrije Universiteit
   Amsterdam; University of Groningen; Vrije Universiteit Amsterdam
RP Dortland, AKBV (corresponding author), Leiden Univ, Med Ctr, Dept Psychiat, POB 9600, NL-2300 RC Leiden, Netherlands.
EM akbvanreedtdortland@lumc.nl
RI Zitman, Frans/E-7705-2010; Penninx, Brenda/S-7627-2017; Giltay,
   Erik/AAL-9948-2021; de Geus, Eco/M-9318-2015
OI de Geus, Eco/0000-0001-6022-2666; Giltay, Erik J./0000-0001-8874-2292
FU Geestkracht program of the Netherlands Organization for Health Research
   and Development (ZonMw) [10-000-1002]; VU University Medical Center; GGZ
   inGeest; Arkin; Leiden University Medical Center; GGZ Rivierduinen;
   University Medical Center Groningen; Lentis; GGZ Friesland; GGZ Drenthe;
   Scientific Institute for Quality of Health Care (IQ Healthcare);
   Netherlands Institute for Health Services Research (NIVEL); Netherlands
   Institute of Mental Health and Addiction (Trimbos)
FX The infrastructure for the NESDA study (www.nesda.nl) is funded through
   the Geestkracht program of the Netherlands Organization for Health
   Research and Development (ZonMw, grant number 10-000-1002) and is
   supported by participating universities and mental health care
   organizations (VU University Medical Center, GGZ inGeest, Arkin, Leiden
   University Medical Center, GGZ Rivierduinen, University Medical Center
   Groningen, Lentis, GGZ Friesland, GGZ Drenthe, Scientific Institute for
   Quality of Health Care (IQ Healthcare), Netherlands Institute for Health
   Services Research (NIVEL) and Netherlands Institute of Mental Health and
   Addiction (Trimbos).
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NR 70
TC 85
Z9 90
U1 0
U2 45
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD FEB
PY 2013
VL 38
IS 2
BP 209
EP 218
DI 10.1016/j.psyneuen.2012.05.017
PG 10
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA 091SR
UT WOS:000315070600005
PM 22717171
DA 2025-06-11
ER

PT J
AU Guo, FQ
   Chen, XC
   Howland, S
   Danza, P
   Niu, ZZ
   Gauderman, WJ
   Habre, R
   McConnell, R
   Yan, MZ
   Whitfield, L
   Li, YJ
   Hodis, HN
   Breton, CV
   Bastain, TM
   Farzan, SF
AF Guo, Fangqi
   Chen, Xinci
   Howland, Steve
   Danza, Phoebe
   Niu, Zhongzheng
   Gauderman, W. James
   Habre, Rima
   McConnell, Rob
   Yan, Mingzhu
   Whitfield, Lora
   Li, Yanjie
   Hodis, Howard N.
   Breton, Carrie V.
   Bastain, Theresa M.
   Farzan, Shohreh F.
TI Perceived Stress From Childhood to Adulthood and Cardiometabolic End
   Points in Young Adulthood: An 18-Year Prospective Study
SO JOURNAL OF THE AMERICAN HEART ASSOCIATION
LA English
DT Article
DE body composition; cardiovascular disease; intima-media thickness;
   metabolic disease; stress
ID INTIMA-MEDIA THICKNESS; CORONARY-HEART-DISEASE; CARDIOVASCULAR RISK;
   BLOOD-PRESSURE; DEPRESSION SYMPTOMS; AIR-QUALITY; ASSOCIATION; CHILDREN;
   SCALE; SUSCEPTIBILITY
AB Background We investigated how childhood-to-adulthood perceived stress patterns predict adult cardiometabolic risk.Methods and Results This study included 276 participants from the Southern California Children's Health Study (2003-2014), and a follow-up assessment (2018-2021). Perceived stress (Perceived Stress Scale) was initially reported by participants' parents for themselves during early childhood (mean age, 6.3 years), and later self-reported during adolescence (13.3 years) and young adulthood (23.6 years). Participants were grouped into 4 stress patterns: consistently high, decreasing, increasing, and consistently low. Cardiometabolic risk was assessed in young adulthood by carotid artery intima-media thickness, systolic and diastolic blood pressure, obesity, percent body fat, android/gynoid ratio, and glycated hemoglobin. A cardiometabolic risk score was generated by summing the clinically abnormal markers. Multivariable linear and logistic regression models were used to (1) examine the associations between Perceived Stress Scale at 3 time points and adult cardiometabolic risk, and (2) assess the impact of stress pattern on adult cardiometabolic risk. Findings suggested that in adulthood, higher Perceived Stress Scale score was associated with increased overall cardiometabolic risk (beta=0.12 [95% CI, 0.01-0.22]), carotid artery intima-media thickness (beta=0.01 [95% CI, 0.0003-0.02]), systolic blood pressure (beta=1.27 [95% CI, 0.09-2.45]), and diastolic blood pressure (beta=0.94 [95% CI, 0.13-1.75]). Individuals with a consistently high adolescence-to-adulthood stress pattern had greater overall cardiometabolic risk (beta=0.31 [95% CI, 0.02-0.60]), android/gynoid ratio (beta=0.07 [95% CI, 0.02-0.13]), percent body fat (beta=2.59 [95% CI, 0.01-5.17]), and greater odds of obesity (odds ratio, 5.57 [95% CI, 1.62-19.10]) in adulthood, compared with those with a consistently low Perceived Stress Scale score.Conclusions Consistently high perceived stress from adolescence to adulthood may contribute to greater cardiometabolic risk in young adulthood.
C1 [Guo, Fangqi; Chen, Xinci; Howland, Steve; Danza, Phoebe; Niu, Zhongzheng; Gauderman, W. James; Habre, Rima; McConnell, Rob; Breton, Carrie V.; Bastain, Theresa M.; Farzan, Shohreh F.] Univ Southern Calif, Keck Sch Med, Dept Populat & Publ Hlth Sci, 1845 N Soto St,Suite 102, Los Angeles, CA 90032 USA.
   [Yan, Mingzhu; Whitfield, Lora; Li, Yanjie; Hodis, Howard N.] Univ Southern Calif, Atherosclerosis Res Unit, Los Angeles, CA 90032 USA.
C3 University of Southern California; University of Southern California
RP Farzan, SF (corresponding author), Univ Southern Calif, Keck Sch Med, Dept Populat & Publ Hlth Sci, 1845 N Soto St,Suite 102, Los Angeles, CA 90032 USA.
EM sffarzan@usc.edu
RI Habre, Rima/AAJ-3385-2020; LI, Yanjie/AAZ-3829-2021; Bastain,
   Theresa/JOZ-4713-2023; Wu, Zhenqiang/HGU-2637-2022; Yan,
   Mingzhu/KBC-6281-2024
OI Chen, Xinci/0009-0002-4619-7892; Habre, Rima/0000-0003-2103-1706; Niu,
   Zhongzheng/0000-0002-7168-8581; Guo, Fangqi/0000-0002-6553-9328
FU National Institute of Environmental Health Sciences [R01ES031590];
   National Institutes of Health Environmental Influences on Child Health
   Outcomes consortium [UH3OD023287]; National Institute of Environmental
   Health Sciences Southern California Environmental Sciences Center
   [P30ES007048, P01ES011627]; Southern California Children's Environmental
   Health Center [P01ES022845, P01ES009581, P2CES033433]; Southern
   California Clinical and Translational Sciences Institute [UL1TR001855,
   UL1TR000130]
FX Funding was provided by National Institute of Environmental Health
   Sciences grant R01ES031590 (PI: Farzan), the National Institutes of
   Health Environmental Influences on Child Health Outcomes consortium
   grant UH3OD023287 (MPIs: Breton, Bastain, Farzan, Habre), the National
   Institute of Environmental Health Sciences Southern California
   Environmental Sciences Center (P30ES007048, P01ES011627), the Southern
   California Children's Environmental Health Center (P01ES022845,
   P01ES009581, P2CES033433), and the Southern California Clinical and
   Translational Sciences Institute (National Institutes of Health National
   Center for Advancing Translational Sciences grants UL1TR001855 and
   UL1TR000130). The funding agencies that supported this work had no role
   in the planning, design, or execution of this study, nor any role in
   data analysis or article preparation.
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NR 67
TC 8
Z9 8
U1 1
U2 4
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
EI 2047-9980
J9 J AM HEART ASSOC
JI J. Am. Heart Assoc.
PD FEB 6
PY 2024
VL 13
IS 3
AR e030741
DI 10.1161/JAHA.123.030741
PG 11
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA LD0R6
UT WOS:001184729600016
PM 38230530
OA gold
DA 2025-06-11
ER

PT J
AU Goldberg, SK
   Conron, KJ
   Halpern, CT
AF Goldberg, Shoshana K.
   Conron, Kerith J.
   Halpern, Carolyn T.
TI Metabolic Syndrome and Economic Strain Among Sexual Minority Young
   Adults
SO LGBT HEALTH
LA English
DT Article
DE cardiovascular disease risk factors; metabolic syndrome; socioeconomic
   factors; young adults
ID EARLY SOCIOECONOMIC ADVERSITY; CARDIOVASCULAR-DISEASE RISK;
   CARDIOMETABOLIC RISK; BISEXUAL POPULATIONS; SUBSTANCE USE; LIFE-COURSE;
   HEALTH; ORIENTATION; STRESS; GAY
AB Purpose: The study tested if sexual orientation is associated with metabolic syndrome (MetS) in young adulthood (ages 24-32), and if economic strain impacts associations. Methods: Gender-stratified logistic regressions were fit among 11,575 young adults (1644 sexual minority [SM]) in Wave IV of The National Longitudinal Study of Adolescent to Adult Health. Results: MetS was not associated with sexual orientation for either gender, yet economic strain was more prevalent among both SM males and females. Additional MetS risk factors (smoking, binge drinking, and lower education) emerged for SM females. Conclusion: Although MetS did not differ by sexual orientation, emergent sexual orientation disparities among females suggest increased future risk.
C1 [Goldberg, Shoshana K.; Conron, Kerith J.; Halpern, Carolyn T.] Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Maternal & Child Hlth, 135 Dauer Dr,401 Rosenau Hall,CB 7455, Chapel Hill, NC 27599 USA.
   [Goldberg, Shoshana K.; Halpern, Carolyn T.] Univ N Carolina, Carolina Populat Ctr, Chapel Hill, NC 27599 USA.
   [Conron, Kerith J.] UCLA, Sch Law, Williams Inst, Los Angeles, CA 90024 USA.
C3 University of North Carolina; University of North Carolina Chapel Hill;
   University of North Carolina; University of North Carolina Chapel Hill;
   University of California System; University of California Los Angeles
RP Goldberg, SK (corresponding author), Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Maternal & Child Hlth, 135 Dauer Dr,401 Rosenau Hall,CB 7455, Chapel Hill, NC 27599 USA.
EM skgold@email.unc.edu
FU NICHD NIH HHS [P01 HD031921, R24 HD050924, R01 HD087365, P2C HD050924]
   Funding Source: Medline
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NR 34
TC 6
Z9 7
U1 0
U2 3
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 2325-8292
EI 2325-8306
J9 LGBT HEALTH
JI LGBT Health
PD JAN 1
PY 2019
VL 6
IS 1
BP 1
EP 8
DI 10.1089/lgbt.2018.0053
PG 8
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA HR8GI
UT WOS:000463394400001
PM 30650052
OA Green Published
DA 2025-06-11
ER

PT J
AU Kazak, F
   Yarim, GF
   Anadol, E
   Salt, A
AF Kazak, Filiz
   Yarim, Gul Fatma
   Anadol, Elvan
   Salt, Ayris
TI Hesperidin alleviates inflammation in the metabolic syndrome model
SO VETERINARSKI ARHIV
LA English
DT Article
DE cytokine; hesperidin; insulin resistance syndrome; liver; rat
ID OXIDATIVE STRESS; ADIPONECTIN; CYTOKINES; GLUCOSE; RATS
AB In metabolic syndrome, activated inflammatory signaling pathways trigger the release of proinflammatory cytokines. Nowadays, the use of natural bioactive compounds is trending as an alternative method for the treatment and management of metabolic syndrome. This study aimed to assess the potential effects of hesperidin in the metabolic syndrome model by analyzing the proinflammatory and anti-inflammatory cytokines in serum and liver. Rats were divided into 4 groups: Control (Rats were fed a standard chow diet and water ad libitum), hesperidin [Rats were fed hesperidin supplemented standard chow diet (1%, 10 g/kg feed) and water ad libitum] metabolic syndrome (Rats were fed standard chow diet with 10% fructose-added-drinking-water), and metabolic syndrome + hesperidin (Rats were fed a hesperidin-added standard chow diet (1%, 10 g/kg) with 10% fructose-added-drinking-water). Rats were sacrificed under ketamine/xylazine anesthesia, blood was obtained and liver tissues were removed. Tumor necrosis factor-alpha, interleukin-1 beta, interleukin-6, interleukin-10, and transforming growth factor-beta in the serum and liver were measured by enzyme-linked immunosorbent assay. In the metabolic syndrome group, higher tumor necrosis factor-alpha, interleukin-1 beta, and interleukin-6, but lower serum and liver interleukin-10 and transforming growth factor-beta were found in the serum and liver compared to the control group. In addition, in the metabolic syndrome + factor-beta were found in the serum and liver compared to the metabolic syndrome groups. Consequently, hesperidin response in the metabolic syndrome rat model.
C1 [Kazak, Filiz] Hatay Mustafa Kemal Univ, Fac Vet Med, Dept Biochem, Hatay, Turkiye.
   [Yarim, Gul Fatma; Salt, Ayris] Ondokuz Mayis Univ, Fac Vet Med, Dept Biochem, Samsun, Turkiye.
   [Anadol, Elvan] Gazi Univ, Lab Anim Breeding & Expt Res Ctr, Ankara, Turkiye.
   [Kazak, Filiz] Hatay Mustafa Kemal Univ, Fac Vet Med, Dept Biochem, TR-31060 Hatay, Turkiye.
C3 Hatay Mustafa Kemal University; Ondokuz Mayis University; Gazi
   University; Hatay Mustafa Kemal University
RP Kazak, F (corresponding author), Hatay Mustafa Kemal Univ, Fac Vet Med, Dept Biochem, TR-31060 Hatay, Turkiye.
EM drfilizkazak@gmail.com
RI Gokceoglu, Ayris/JNS-8053-2023
FU Ondokuz Mayis University Scientific Research Projects Unit
   [PYO.VET.1901.17.015]
FX The research was funded by Ondokuz Mayis University Scientific Research
   Projects Unit (PYO.VET.1901.17.015) . The abstract of this study has
   been presented as an oral presentation in the International Asian
   Congress on Contemporary Sciences -VI, May 27-29, 2022.
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NR 36
TC 1
Z9 1
U1 3
U2 6
PU UNIV ZAGREB VET FACULTY
PI ZAGREB
PA P O BOX 190, 41001 ZAGREB, CROATIA
SN 0372-5480
EI 1331-8055
J9 VET ARHIV
JI Vet. Arh.
PY 2024
VL 94
IS 1
BP 67
EP 76
DI 10.24099/vet.arhiv.2025
PG 10
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA IR2T9
UT WOS:001167998500001
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU González-Rivas, JP
   Mechanick, JI
   Iglesias-Fortes, R
   De-Oliveira-Gomes, D
   Silva, J
   Valencia, J
   Figueroa, E
   Duran, M
   Ugel, E
   Infante-García, MM
   Marulanda, MI
   Nieto-Martínez, R
AF Gonzalez-Rivas, Juan P.
   Mechanick, Jeffrey I.
   Iglesias-Fortes, Rocio
   De-Oliveira-Gomes, Diana
   Silva, Jesus
   Valencia, Jose
   Figueroa, Estherbany
   Duran, Maritza
   Ugel, Eunice
   Infante-Garcia, Maria M.
   Marulanda, Maria Ines
   Nieto-Martinez, Ramfis
TI Optimal waist circumference cutoff values to predict cardiometabolic
   alterations in a Venezuela national representative sample. The EVESCAM
   study
SO ARCHIVOS DE CARDIOLOGIA DE MEXICO
LA English
DT Article
DE Abdominal obesity; Adiposity; Metabolic syndrome; Venezuela; Waist
   circumference
ID METABOLIC SYNDROME; CLINICAL ENDOCRINOLOGISTS; AMERICAN ASSOCIATION;
   CHRONIC DISEASE; BLOOD-PRESSURE; RISK; PREVALENCE; STRESS
AB Objective: Waist circumference (WC) value reflects abdominal adiposity, but the amount abdominal fat that is associated to cardiometabolic risk factors varies among ethnicities. Determination of metabolic abnormalities has not undergone a WC adaptation process in Venezuela. The aim of the study was (1) to determine the optimal WC cutoff value associated with >_2 cardiometabolic alterations and (2) incorporating this new WC cutoff, to determine the prevalence of abdominal obesity and cardiometabolic risk factors related in Venezuela. Methods: The study was national population-based, cross-sectional, and randomized sample, from 2014 to 2017. To assess performance of WC for identifying cardiometabolic alterations, receiver operating characteristics curves, area under the curve (AUC), sensitivity, specificity, and positive likelihood ratios were calculated. Results: Three thousand three hundred eighty-seven adults were evaluated with mean age of 41.2 +/- 15.8 years. Using the best tradeoff between sensitivity and specificity, WC cutoffs of 90 cm in men (sensitivity = 72.4% and specificity = 66.1%) and 86 cm in women (sensitivity = 76.2% and specificity = 61.4%) were optimal for aggregation of >_2 cardiometabolic alterations. AUC was 0.75 in men and 0.73 in women using these new cutoffs. Prevalence of abdominal obesity and metabolic syndrome was 59.6% (95 CI; 57.5-61.7) and 47.6% (95 CI; 45.2-50.0), respectively. Cardiometabolic risk factors were associated with being men, higher age, adiposity, and living in northern or western regions. Conclusion: The optimal WC values associated with cardiometabolic alterations were 90 cm in men and 86 cm in women. More than half of the Venezuelan population had abdominal obesity incorporating this new WC cutoff.
C1 [Gonzalez-Rivas, Juan P.] St Annes Univ Hosp Brno, Internat Clin Res Ctr, Brno, Czech Republic.
   [Gonzalez-Rivas, Juan P.; Nieto-Martinez, Ramfis] Harvard Univ, Harvard TH Chan Sch Publ Hlth, Dept Global Hlth & Population, Boston, MA 02115 USA.
   [Gonzalez-Rivas, Juan P.; Iglesias-Fortes, Rocio; De-Oliveira-Gomes, Diana; Silva, Jesus; Valencia, Jose; Figueroa, Estherbany; Duran, Maritza; Ugel, Eunice; Infante-Garcia, Maria M.; Marulanda, Maria Ines; Nieto-Martinez, Ramfis] Fnd Clin Publ Hlth & Epidemiol Res Venezuela, Caracas, Venezuela.
   [Mechanick, Jeffrey I.] Icahn Sch Med Mt Sinai, Div Cardiol, New York, NY USA.
   [Mechanick, Jeffrey I.] Icahn Sch Med Mt Sinai, Div Endocrinol Diabet & Bone Dis, New York, NY USA.
   [Ugel, Eunice] Univ Ctr Occidental Lisandro Alvarado, Sch Med, Dept Social & Prevent Med, Publ Hlth Res Unit, Barquisimeto, Venezuela.
   [Nieto-Martinez, Ramfis] LifeDoc Diabet & Obes Clin, Memphis, TN USA.
   [Nieto-Martinez, Ramfis] Univ Ctr Occidental Lisandro Alvarado, Sch Med, Dept Physiol, Barquisimeto, Venezuela.
C3 St. Anne's University Hospital Brno (FNUSA); Harvard University; Harvard
   T.H. Chan School of Public Health; Icahn School of Medicine at Mount
   Sinai; Icahn School of Medicine at Mount Sinai
RP González-Rivas, JP (corresponding author), St Annes Univ Hosp Brno, Internat Clin Res Ctr, Brno, Czech Republic.; González-Rivas, JP (corresponding author), Harvard Univ, Harvard TH Chan Sch Publ Hlth, Dept Global Hlth & Population, Boston, MA 02115 USA.; González-Rivas, JP (corresponding author), Fnd Clin Publ Hlth & Epidemiol Res Venezuela, Caracas, Venezuela.
EM juan.gonzalez@fnusa.cz
RI Gonzalez Rivas, Juan Pablo/HZK-6756-2023; Martinez, Andrea/KHX-0081-2024
OI Valencia Portillo, Jose Urbey/0000-0001-6865-9424; Nieto-Martinez,
   Ramfis/0000-0002-0575-7534
FU Novartis
FX The EVESCAM was partially funded by a grant of Novartis and donations.
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NR 39
TC 1
Z9 2
U1 0
U2 1
PU INST NACIONAL CARDIOLOGIA IGNACIO CHAVEZ
PI MEXICO CITY
PA DEPT PUBLICACIONES, JUAN BADIANO NO 1, COL. SECCION XVI, DELEGACION
   TLALPAN, MEXICO CITY, D F 00000, MEXICO
SN 1405-9940
J9 ARCH CARDIOL MEX
JI Arch. Cardiol. Mex.
PD JUL-SEP
PY 2021
VL 91
IS 3
BP 272
EP 280
DI 10.24875/ACM.20000165
PG 9
WC Cardiac & Cardiovascular Systems; Peripheral Vascular Disease
WE Emerging Sources Citation Index (ESCI)
SC Cardiovascular System & Cardiology
GA WF8AZ
UT WOS:000706524600002
PM 33362194
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Farrell, AK
   Waters, TEA
   Young, ES
   Englund, MM
   Carlson, EE
   Roisman, GI
   Simpson, JA
AF Farrell, Allison K.
   Waters, Theodore E. A.
   Young, Ethan S.
   Englund, Michelle M.
   Carlson, Elizabeth E.
   Roisman, Glenn I.
   Simpson, Jeffry A.
TI Early maternal sensitivity, attachment security in young adulthood, and
   cardiometabolic risk at midlife
SO ATTACHMENT & HUMAN DEVELOPMENT
LA English
DT Article
DE Parenting; attachment; cardiometabolic risk; secure base script;
   coherence of mind
ID BASE SCRIPT KNOWLEDGE; PHYSICAL HEALTH; METABOLIC SYNDROME; CHILDHOOD
   ABUSE; REPRESENTATIONS; BEHAVIOR; QUALITY; INFLAMMATION; ASSOCIATIONS;
   DEPRESSION
AB Children who experience high-quality early parenting tend to have better physical health, but limited research has tested whether this association extends into adulthood using prospective, observational assessments. Likewise, mechanisms that may explain such links have not yet been illuminated. In this study, we test whether the quality of early maternal sensitivity experienced during the first 31/2 years of life predicts cardiometabolic risk at midlife (ages 37 and 39 years) via attachment representations measured in young adulthood (ages 19 and 26 years). We do so by comparing the predictive significance of two different forms of attachment representations coded from the Adult Attachment Interview (AAI): (a) secure base script knowledge and (b) coherence of mind. Using data from the Minnesota Longitudinal Study of Risk and Adaptation, we find that early maternal sensitivity is negatively associated with cardiometabolic risk at midlife. Secure base script knowledge (but not coherence of mind) partially mediated this link. These findings are consistent with the possibility that early parenting has lasting significance for physical health in part by promoting higher levels of secure base script knowledge.
C1 [Farrell, Allison K.] Wayne State Univ, Dept Psychol, 5057 Woodward Ave, Detroit, MI 48202 USA.
   [Farrell, Allison K.] Wayne State Univ, Ctr Mol Med & Genet, Detroit, MI USA.
   [Waters, Theodore E. A.] NYU Abu Dhabi, Dept Psychol, Abu Dhabi, U Arab Emirates.
   [Young, Ethan S.; Simpson, Jeffry A.] Univ Minnesota, Dept Psychol, Minneapolis, MN USA.
   [Englund, Michelle M.; Carlson, Elizabeth E.; Roisman, Glenn I.] Univ Minnesota, Inst Child Dev, 51 E River Rd, Minneapolis, MN 55455 USA.
C3 Wayne State University; Wayne State University; New York University; New
   York University Abu Dhabi; University of Minnesota System; University of
   Minnesota Twin Cities; University of Minnesota System; University of
   Minnesota Twin Cities
RP Farrell, AK (corresponding author), Wayne State Univ, Dept Psychol, 5057 Woodward Ave, Detroit, MI 48202 USA.
EM akfarrell10@gmail.com
RI ; Young, Ethan/G-6586-2018
OI Englund, Michelle/0000-0002-3800-3157; Simpson,
   Jeff/0000-0003-1899-2493; Young, Ethan/0000-0002-8232-0184
FU National Institutes of Aging [5R01AG039453-04]
FX This research was funded by a National Institutes of Aging
   [5R01AG039453-04] grant to Jeffry A. Simpson.
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NR 73
TC 41
Z9 47
U1 0
U2 22
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 1461-6734
EI 1469-2988
J9 ATTACH HUM DEV
JI Attach. Hum. Dev.
PD JAN 2
PY 2019
VL 21
IS 1
SI SI
BP 70
EP 86
DI 10.1080/14616734.2018.1541517
PG 17
WC Psychology, Developmental
WE Social Science Citation Index (SSCI)
SC Psychology
GA HC2EH
UT WOS:000451614600006
PM 30428778
DA 2025-06-11
ER

PT J
AU Prout, PR
   Nichols, SD
   Ramcharitar-Borne, A
   Dalrymple, N
AF Prout, P. R.
   Nichols, S. D.
   Ramcharitar-Borne, A.
   Dalrymple, N.
TI Cardiometabolic Risk and its Antecedents among Law Enforcement Officers
   in Trinidad and Tobago
SO WEST INDIAN MEDICAL JOURNAL
LA English
DT Article
DE Cardiometabolic; lifestyle behaviours; police officers; smokers
ID METABOLIC SYNDROME; CARDIOVASCULAR-DISEASE; BLOOD-PRESSURE; HEALTH;
   PREVALENCE; PERSONNEL; STRESS
AB Objective: To evaluate cardiometabolic risk and associated lifestyle behaviours among police officers.
   Methods: Participants completed a validated self-administered questionnaire consisting of socio-demographic, dietary and physical activity items. Following this, blood pressure and anthropometry were measured using standard procedures. Participation in the study was voluntary. The study was approved by the Acting Commissioner of Police, Trinidad and Tobago Police Service.
   Results: A total of 400 (females = 138; males = 262) officers participated in the study. Male officers were more likely than their female counterparts to have elevated blood pressures, waist circumferences and be smokers. In partial correlation analyses controlling for age, ethnicity, education level and marital status, body mass index was significantly inversely associated with the consumption of vegetables and peas and beans and positively associated with the consumption of sodas and cigarette smoking.
   Conclusion: Our results indicate that high levels of cardiometabolic risk were associated with unhealthy lifestyle practices among participants.
C1 [Prout, P. R.; Nichols, S. D.; Ramcharitar-Borne, A.; Dalrymple, N.] Univ West Indies, Dept Agr Econ & Extens, Fac Food & Agr, St Augustine, Trinidad Tobago.
C3 University West Indies Mona Jamaica; University West Indies Saint
   Augustine
RP Prout, PR (corresponding author), Univ West Indies, Dept Agr Econ & Extens, Fac Food & Agr, St Augustine, Trinidad Tobago.
EM patricerp@gmail.com
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NR 17
TC 0
Z9 0
U1 0
U2 0
PU UNIV WEST INDIES FACULTY MEDICAL SCIENCES
PI KINGSTON
PA MONA CAMPUS, KINGSTON 7, JAMAICA
SN 0043-3144
EI 2309-5830
J9 W INDIAN MED J
JI West Ind. Med. J.
PY 2024
VL 71
IS 1
BP 24
EP 28
DI 10.7727/wimj.2017.202
PG 5
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA ZV1N8
UT WOS:001277972500006
DA 2025-06-11
ER

PT J
AU Saboya, PP
   Bodanese, LC
   Zimmermann, PR
   Gustavo, AD
   Assumpçao, CM
   Londero, F
AF Saboya, Patricia Pozas
   Bodanese, Luiz Carlos
   Zimmermann, Paulo Roberto
   Gustavo, Andreia da Silva
   Assumpcao, Caroline Melo
   Londero, Fernanda
TI Metabolic syndrome and quality of life: a systematic review
SO REVISTA LATINO-AMERICANA DE ENFERMAGEM
LA English
DT Review
DE Metabolic Syndrome X; Quality of Life; Risk Factors; Secondary
   Prevention; Cardiovascular Diseases; Metabolism
ID STYLE INTERVENTION; NATIONAL-HEALTH; WOMENS HEALTH; OBESITY; WEIGHT;
   IMPACT; ADULTS; PREVALENCE; DEPRESSION; RISK
AB Objectives: to present currently available evidence to verify the association between metabolic syndrome and quality of life. Method: Cochrane Library, EMBASE, Medline and LILACS databases were studied for all studies investigating the association with metabolic syndrome and quality of life. Two blinded reviewers extracted data and one more was chosen in case of doubt. Results: a total of 30 studies were included, considering inclusion and exclusion criteria, which involved 62.063 patients. Almost all studies suggested that metabolic syndrome is significantly associated with impaired quality of life. Some, however, found association only in women, or only if associated with depression or Body Mass Index. Merely one study did not find association after adjusted for confounding factors. Conclusion: although there are a few studies available about the relationship between metabolic syndrome and quality of life, a growing body of evidence has shown significant association between metabolic syndrome and the worsening of quality of life. However, it is necessary to carry out further longitudinal studies to confirm this association and verify whether this relationship is linear, or only an association factor.
C1 [Bodanese, Luiz Carlos; Zimmermann, Paulo Roberto] Pontificia Univ Catolica Rio Grande do Sul, Fac Med, Porto Alegre, RS, Brazil.
   [Gustavo, Andreia da Silva] Pontificia Univ Catolica Rio Grande do Sul, Fac Enfermagem Nutr & Fisioterapia, Porto Alegre, RS, Brazil.
C3 Pontificia Universidade Catolica Do Rio Grande Do Sul; Pontificia
   Universidade Catolica Do Rio Grande Do Sul
RP Saboya, PP (corresponding author), Pontificia Univ Catolica Rio Grande do Sul, Ave Ipiranga,6690, BR-90610000 Porto Alegre, RS, Brazil.
EM patricia.saboya@acad.pucrs.br
CR Alberti G., 2006, The IDF consensus worldwide definition of the metabolic syndrome
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NR 38
TC 70
Z9 74
U1 0
U2 7
PU UNIV SAO PAULO, ESCOLA DE ENFERMAGEM DE RIBEIRAO PRETO
PI RIBEIRAO PRETO
PA AV BANDEIRANTES, 3900, RIBEIRAO PRETO, SP 14040-902  A, BRAZIL
SN 1518-8345
J9 REV LAT-AM ENFERM
JI Rev. Latino-Am. Enfermagem
PY 2016
VL 24
AR e2848
DI 10.1590/1518-8345.1573.2848
PG 8
WC Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing
GA EN8VI
UT WOS:000396277500092
PM 27901223
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Yoon, SR
   Song, J
   Lee, JH
   Kim, OY
AF Yoon, So Ra
   Song, Juhyun
   Lee, Jong Hwa
   Kim, Oh Yoen
TI Phosphorylation of Histone H2A.X in Peripheral Blood Mononuclear Cells
   May Be a Useful Marker for Monitoring Cardiometabolic Risk in
   Nondiabetic Individuals
SO DISEASE MARKERS
LA English
DT Article
ID METABOLIC SYNDROME; DNA-DAMAGE; OXIDATIVE STRESS; LIVER-ENZYMES;
   ASSOCIATION; GAMMA-H2AX; PREVALENCE; REPAIR; AGE
AB Phosphorylation of H2A.X (serine 139) in the histone H2A family located in the downstream of the DNA damage kinase signaling cascade is an important indicator of DNA damage. Recently, phosphorylation of H2A.X was proposed as a sensitive biomarker of aging. This study investigated if phosphorylation of H2A.X in peripheral blood mononuclear cells (PBMCs) is associated with cardiometabolic risk in nondiabetic individuals. Basic parameters and oxidative stress/inflammatory markers were measured in nondiabetic healthy Koreans (n = 119). Phosphorylation of H2A.X was measured randomly among the study subjects using a flow cytometer. According to the number of metabolic syndrome risk factor (MetS-RF), the study subjects were subdivided into "super healthy" (MetS - RF = 0, n = 71) and "MetS-risk" (MetS - RF = 1, n = 48) groups. Phosphorylation of H2A. X in PBMCs (percentages and mean fluorescence intensity) was significantly higher in the MetS-risk group than in the super healthy group after adjusting for age, sex, cigarette smoking, and alcohol consumption. Phosphorylated H2A. X was positively correlated with the number of MetS-RF as well as waist circumference, blood pressures, triglyceride, Hb(A1C), oxidized LDL, high sensitivity C-reactive protein, tumor necrosis factor-alpha, and alanine aminotransferase after the adjustment. The present study suggested that phosphorylated H2A.X in circulating PBMCs measured by flow cytometer may be a useful marker for monitoring cardiometabolic risk in nondiabetic individuals.
C1 [Yoon, So Ra; Kim, Oh Yoen] Dong A Univ, Brain Busan Project 21, Dept Food Sci & Nutr, Busan 49315, South Korea.
   [Song, Juhyun] Chonnam Natl Univ, Dept Biomed Sci, Ctr Creat Biomed Scientists, Gwangju 61469, South Korea.
   [Lee, Jong Hwa] Dong A Univ Hosp, Dept Rehabil Med, Busan 49315, South Korea.
   [Kim, Oh Yoen] Dong A Univ Hosp, Human Life Res Ctr, Busan 49315, South Korea.
C3 Dong A University; Chonnam National University; Dong A University; Dong
   A University
RP Kim, OY (corresponding author), Dong A Univ, Brain Busan Project 21, Dept Food Sci & Nutr, Busan 49315, South Korea.; Kim, OY (corresponding author), Dong A Univ Hosp, Human Life Res Ctr, Busan 49315, South Korea.
EM oykim@dau.ac.kr
RI Lee, Jaewon/N-9064-2013; Kim, Oh/AAA-6492-2022; Song,
   Juhyun/AAH-3162-2020
OI Song, Juhyun/0000-0002-9165-8507
FU National Research Foundation of Korea - Korean Government
   [2016R1A2B4013627]
FX The authors thank the research volunteers who participated in this
   study. This study was supported by the National Research Foundation of
   Korea grant funded by the Korean Government (2016R1A2B4013627).
CR American DA, 2010, DIABETES CARE S1, V33, pS11, DOI [DOI 10.2337/dc10-S011, 10.2337/dc10-S011, DOI 10.2337/DC10-S011]
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NR 39
TC 3
Z9 3
U1 0
U2 3
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 0278-0240
EI 1875-8630
J9 DIS MARKERS
JI Dis. Markers
PY 2017
VL 2017
AR 2050194
DI 10.1155/2017/2050194
PG 9
WC Biotechnology & Applied Microbiology; Genetics & Heredity; Medicine,
   Research & Experimental; Pathology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Genetics & Heredity; Research &
   Experimental Medicine; Pathology
GA EV7BD
UT WOS:000401928200001
PM 28572698
OA Green Published, hybrid
DA 2025-06-11
ER

PT J
AU Koning, M
   Vink, J
   Visscher, TLS
   Larsen, J
AF Koning, Maaike
   Vink, Jacqueline
   Visscher, Tommy L. S.
   Larsen, Junilla
TI Maternal stress and depressive symptoms and adolescents' body mass
   index: a prospective study
SO BMC PUBLIC HEALTH
LA English
DT Article
DE Longitudinal study; Adolescence; Overweight; Maternal stress; Maternal
   depression; BMI
ID WEIGHT-RELATED BEHAVIORS; PERCEIVED STRESS; CHILDHOOD OVERWEIGHT;
   UNITED-STATES; METABOLIC SYNDROME; FOOD-CONSUMPTION; EARLY ADULTHOOD;
   SHORT-FORM; OBESITY; ASSOCIATIONS
AB BackgroundGrowing evidence suggests that maternal mental health issues are associated with (young) children's weight outcomes. However, most studies have been limited by cross-sectional designs and have been aimed at (younger) children. The current prospective study focuses on the link between maternal mental health (i.e., psychological stress and depressive symptoms) and adolescents' zBMI development.MethodsThe participants in the present study were part of wave 1 and 2 of a longitudinal study on Dutch adolescents' and their parents' health behavior. Adolescents (aged 10-14) and their parents were recruited through six secondary schools in the South and the East of the Netherlands. For this study, we only included biological mothers and their adolescent children who participated in both waves, with data on the main measures in both waves, leaving a final sample of 336 biological mother-child dyads. Adolescents height and weight were measured, and both parents and adolescents filled in validated questionnaires on perceived stress and depressive symptoms and answered additional questions concerning domain-specific stress. Regression analyses were performed in R to examine longitudinal links between maternal stress and depressive symptoms at baseline (T1) and adolescents' BMI standard deviation scores (zBMI) 6months later (T2), corrected for baseline zBMI and covariates.ResultsMaternal general perceived stress (beta=.20, p=.002) at T1 preceded higher adolescents' zBMI at T2, after controlling for baseline zBMI and other covariates, whereas maternal depressive symptoms at T1 (beta=-.05, p=.44) and other domain-specific stress did not (maternal financial stress, maternal stress at work, maternal stress at home). Additionally, lower educational level among adolescents (beta=.16, p=.001) and adolescent depressive symptoms (beta=.16, p=.001) was associated with a higher zBMI at T2.ConclusionsResults suggest that maternal general stress, but not depressive symptoms, may influence adolescents' weight development. Our findings warrant future investigation on whether and how general stress among mothers may predict weight increases of their adolescent offspring.
C1 [Koning, Maaike; Vink, Jacqueline; Larsen, Junilla] Radboud Univ Nijmegen, Behav Sci Inst, Dev Psychol, POB 9104, NL-6500 HE Nijmegen, Netherlands.
   [Koning, Maaike] Windesheim Univ Appl Sci, Knowledge Ctr Hlth & Social Work, Dept Hlth Soc, Zwolle, Netherlands.
   [Visscher, Tommy L. S.] Hanze Univ Appl Sci, Groningen, Netherlands.
C3 Radboud University Nijmegen
RP Koning, M (corresponding author), Radboud Univ Nijmegen, Behav Sci Inst, Dev Psychol, POB 9104, NL-6500 HE Nijmegen, Netherlands.; Koning, M (corresponding author), Windesheim Univ Appl Sci, Knowledge Ctr Hlth & Social Work, Dept Hlth Soc, Zwolle, Netherlands.
EM m.koning@pwo.ru.nl
RI Visscher, Tommy/AHE-5878-2022
FU Behavioural Science Institute of Radboud University in Nijmegen, the
   Netherlands; Windesheim University of Applied Sciences and the
   Behavioural Science Institute of Radboud University in Nijmegen, the
   Netherlands
FX We received no specific grant from any funding agency in public,
   commercial or non-profit sectors. This study was funded by the
   Behavioural Science Institute of Radboud University in Nijmegen, the
   Netherlands. The study received no external funding. The analysis and
   interpretation of the data and the writing of this manuscript were
   funded by Windesheim University of Applied Sciences and the Behavioural
   Science Institute of Radboud University in Nijmegen, the Netherlands.
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NR 101
TC 5
Z9 5
U1 0
U2 3
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2458
J9 BMC PUBLIC HEALTH
JI BMC Public Health
PD APR 7
PY 2021
VL 21
IS 1
AR 675
DI 10.1186/s12889-021-10721-z
PG 13
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA RK0KB
UT WOS:000637993200013
PM 33827481
OA Green Submitted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Null, G
   Pennesi, L
AF Null, Gary
   Pennesi, Luanne
TI Diet and lifestyle intervention on chronic moderate to severe depression
   and anxiety and other chronic conditions
SO COMPLEMENTARY THERAPIES IN CLINICAL PRACTICE
LA English
DT Article
ID RANDOMIZED CONTROLLED-TRIAL; QUALITY-OF-LIFE; MINDFULNESS-MEDITATION;
   VEGAN DIET; STRESS REDUCTION; MEDITERRANEAN DIET; METABOLIC SYNDROME;
   PHYSICAL-EXERCISE; FATIGUE SYMPTOMS; BLOOD-PRESSURE
AB This group study explored how an intervention of diet, lifestyle and behavior modification, including a plant-based diet, daily exercise and mindfulness techniques, would affect 500 adult men and women participants diagnosed with chronic moderate to severe depression and anxiety and other conditions during a 12 week period. An analysis of the health outcomes detailed in self-reported diary entries was carried out at the conclusion of the 12 week period. These reports noted improvements in depression, anxiety and all other conditions addressed by the study, with the majority of participants reporting substantial benefits. A six month follow up indicated that these benefits persisted in most of the participants. These results demonstrate that an intervention of diet, exercise, lifestyle and behavior modification may provide considerable benefits for moderate to severe depression and anxiety as well as other conditions. (C) 2017 Elsevier Ltd. All rights reserved.
C1 [Null, Gary; Pennesi, Luanne] Fairleigh Dickinson Univ, Teaneck, NJ 07666 USA.
C3 Fairleigh Dickinson University
RP Null, G (corresponding author), Fairleigh Dickinson Univ, Teaneck, NJ 07666 USA.
EM art@garynull.com
RI Perevozcikova, Natalia/N-1672-2018
OI Perevozcikova, Natalia/0000-0002-7897-4927
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NR 46
TC 34
Z9 42
U1 2
U2 44
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1744-3881
EI 1873-6947
J9 COMPLEMENT THER CLIN
JI Complement. Ther. Clin. Pract.
PD NOV
PY 2017
VL 29
BP 189
EP 193
DI 10.1016/j.ctcp.2017.09.007
PG 5
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Integrative & Complementary Medicine
GA FN6ZM
UT WOS:000416166000022
PM 29122259
DA 2025-06-11
ER

PT J
AU Vigna, L
   Vassalle, C
   Tirelli, AS
   Gori, F
   Tomaino, L
   Sabatino, L
   Bamonti, F
AF Vigna, Luisella
   Vassalle, Cristina
   Tirelli, Amedea Silvia
   Gori, Francesca
   Tomaino, Laura
   Sabatino, Laura
   Bamonti, Fabrizia
TI Gender-related association between uric acid, homocysteine,
   γ-glutamyltransferase, inflammatory biomarkers and metabolic syndrome in
   subjects affected by obesity
SO BIOMARKERS IN MEDICINE
LA English
DT Article
DE inflammation; metabolic syndrome; oxidative stress; people with obesity
   (according to Canadian Obesity Network CON-RCO); uric acid
ID CARDIOMETABOLIC RISK-FACTORS; CARDIOVASCULAR RISK; OXIDATIVE STRESS;
   HYPERURICEMIA; PREDICTOR; DISEASE; MARKER; WOMEN
AB Aim: Evaluation of gender-related differences in uric acid (UA), homocysteine and inflammatory biomarkers as metabolic syndrome (MetS) determinants. Patients & methods: Anthropometric and routine data were obtained from 825 obese subjects (591 F, mean age 54 +/- 14 years). Results: Hyperuricemia was 24% in both genders. Waist circumference, creatinine, triglycerides, C-reactive protein and.-glutamyltransferase were identified as UA-independent determinants in females and creatinine and insulin in males. Hyperuricemia increased MetS risk in both genders (2.8-fold and 1.5-fold in males and females). Conclusion: UA and.-glutamyltransferase positively relate to MetS in both genders, although inflammatory abnormalities are closer related to UA and MetS in females. These differences in gender physiology may account for epidemiologic gender disparities and help to develop gender-targeted clinical strategies.
C1 [Vigna, Luisella; Gori, Francesca] Fdn IRCCS Ca Granda, Osped Maggiore Policlin, Dept Prevent Med, Workers Hlth Promot Unit, Milan, Italy.
   [Vassalle, Cristina] Fdn G Monasterio, CNR Reg Toscana, Pisa, Italy.
   [Tirelli, Amedea Silvia; Tomaino, Laura] Fdn IRCCS Ca Granda, Osped Maggiore Policlin, Lab Clin Chem & Microbiol, Milan, Italy.
   [Sabatino, Laura] Italian Natl Res Council, Inst Clin Physiol, Pisa, Italy.
   [Bamonti, Fabrizia] Univ Milan, Dept Biomed Surg & Dent Sci, Milan, Italy.
C3 IRCCS Ca Granda Ospedale Maggiore Policlinico; IRCCS Ca Granda Ospedale
   Maggiore Policlinico; Consiglio Nazionale delle Ricerche (CNR);
   University of Milan
RP Vassalle, C (corresponding author), Fdn G Monasterio, CNR Reg Toscana, Pisa, Italy.
EM cristina.vassalle@ftgm.it
RI Sabatino, Laura/AAX-8985-2020
OI Vigna, Luisella/0000-0001-5014-721X; Gori, Francesca/0000-0001-8330-5077
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NR 34
TC 14
Z9 14
U1 0
U2 11
PU FUTURE MEDICINE LTD
PI LONDON
PA UNITEC HOUSE, 3RD FLOOR, 2 ALBERT PLACE, FINCHLEY CENTRAL, LONDON, N3
   1QB, ENGLAND
SN 1752-0363
EI 1752-0371
J9 BIOMARK MED
JI Biomark. Med.
PD OCT
PY 2017
VL 11
IS 10
BP 857
EP 865
DI 10.2217/bmm-2017-0072
PG 9
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA FO0GY
UT WOS:000416422600005
PM 29069913
DA 2025-06-11
ER

PT J
AU Villamil-Parra, W
   Moscoso-Loaiza, L
AF Villamil-Parra, Wilder
   Moscoso-Loaiza, Luisa
TI Effects of physical exercise on Irisin and BDNF concentrations, and
   their relationship with cardiometabolic and mental health of individuals
   with Metabolic Syndrome: A Systematic Review
SO EXPERIMENTAL GERONTOLOGY
LA English
DT Review
DE Physical exercise; Metabolic syndrome; Irisin; Brain-derived
   neurotrophic factor; Mental health
ID NEUROTROPHIC FACTOR; HORMONE IRISIN; BRAIN
AB Chronic Non-Communicable Diseases (NCDs), including cardiovascular diseases, cancer, chronic respiratory diseases, and diabetes, are the leading global causes of mortality, accounting for 71 % of deaths annually. Metabolic Syndrome (MS), characterized by hypertension, obesity, insulin resistance, and dyslipidemia, is a significant risk factor for NCDs. Physical inactivity exacerbates these conditions, contributing to poor cardiovascular and mental health outcomes. Objective: To analyze the effects of physical exercise on Irisin and Brain-Derived Neurotrophic Factor (BDNF) concentrations and their relationship with cardiometabolic and mental health of individuals with MS. Methods: A systematic review was conducted of articles published between August 2023 and June 2024 in ScienceDirect, PubMed, and SciELO, following PRISMA guidelines. Inclusion criteria encompassed observational studies, clinical trials, and reviews with high methodological quality. The review focused on Irisin, BDNF, physical exercise, and MS. Results: A total of 584 articles were identified, with 43 selected for detailed analysis. The review highlights that physical exercise significantly impacts Irisin and BDNF levels, which in turn influence metabolic and mental health. Irisin, a myokine secreted during exercise, promotes the conversion of white adipose tissue to brown adipose tissue, enhancing energy expenditure and metabolic health. Elevated Irisin levels are associated with improved cognitive function and mental well-being. BDNF, a neurotrophin, supports neuronal growth and cognitive function. Exercise-induced increases in BDNF levels are linked to enhanced neuroplasticity, reduced anxiety, and improved mood. Conclusion: Understanding the role of Irisin and BDNF in response to physical exercise offers valuable insights for developing strategies to manage and prevent MS and its related mental health issues. Further research is needed to elucidate the molecular mechanisms involved.
C1 [Villamil-Parra, Wilder] Univ Sabana, Fac Enfermeria & Rehabil, Dept Movimiento Corporal Humano, Puente Comun Km 7, Chia, Cundinamarca, Colombia.
   [Moscoso-Loaiza, Luisa] Univ Nacl Colombia, Fac Enfermeria, Dept Enfermeria, Sede Bogota, Carrera 30 45-03, Bogota, DC, Colombia.
C3 Universidad de La Sabana; Universidad Nacional de Colombia
RP Moscoso-Loaiza, L (corresponding author), Carrera 30 45-03, Bogota, DC, Colombia.
EM wilder.villamil@unisabana.edu.co; lfmoscosol@unal.edu.co
RI Villamil-Parra, Wilder/JSL-4311-2023; Moscoso Loaiza,
   Luisa/HNQ-6473-2023
OI Moscoso Loaiza, Luisa Fernanda/0000-0002-0580-1865; Villamil-Parra,
   Wilder/0000-0002-1717-1020
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NR 73
TC 1
Z9 1
U1 2
U2 2
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0531-5565
EI 1873-6815
J9 EXP GERONTOL
JI Exp. Gerontol.
PD DEC
PY 2024
VL 198
AR 112640
DI 10.1016/j.exger.2024.112640
EA NOV 2024
PG 10
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA S1H9J
UT WOS:001395833400001
PM 39579805
OA hybrid
DA 2025-06-11
ER

PT J
AU Verhaegen, A
   Van Gaal, L
AF Verhaegen, A.
   Van Gaal, L.
TI Do E-cigarettes induce weight changes and increase cardiometabolic risk?
   A signal for the future
SO OBESITY REVIEWS
LA English
DT Article
DE Cardiometabolic risk; e-cigarette; smoking; weight
ID ELECTRONIC CIGARETTES; INSULIN-RESISTANCE; SMOKING-CESSATION;
   CARDIOVASCULAR-DISEASE; NICOTINE DELIVERY; OXIDATIVE STRESS; SECONDHAND
   SMOKE; TOBACCO SMOKING; ACUTE IMPACT; BODY-WEIGHT
AB The prevalence of non-cigarette tobacco use in electronic cigarettes, also called vaping, is rapidly increasing, especially in adolescents and young adults, due to attractive marketing techniques promoting them as healthier alternatives to conventional tobacco cigarettes.
   Although smoking is associated with weight loss, it increases insulin resistance and attributes to other features of the metabolic syndrome, increasing the cardiometabolic risk profile.
   Whether vaping has the same deleterious effects on metabolic parameters as regular cigarette smoke has not yet been studied thoroughly in humans. However, animal model experiments attribute comparable effects of e-cigarette smoking, even without nicotine exposure, on weight and metabolic parameters as compared to smoking cigarettes.
   In this review paper, we want to give an overview of published data on the effects on weight and cardiometabolic parameters of e-cigarette use and formulate some mechanistic hypotheses.
C1 [Verhaegen, A.; Van Gaal, L.] Antwerp Univ Hosp, Dept Endocrinol Diabetol & Metab, B-2650 Edegem, Belgium.
C3 University of Antwerp
RP Van Gaal, L (corresponding author), Antwerp Univ Hosp, Dept Endocrinol Diabetol & Metab, B-2650 Edegem, Belgium.
EM luc.vangaal@uza.be
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NR 64
TC 21
Z9 22
U1 0
U2 19
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1467-7881
EI 1467-789X
J9 OBES REV
JI Obes. Rev.
PD OCT
PY 2017
VL 18
IS 10
BP 1136
EP 1146
DI 10.1111/obr.12568
PG 11
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism
GA FF9MI
UT WOS:000409340200003
PM 28660671
DA 2025-06-11
ER

PT J
AU Cho, Y
   Shin, SY
   Shin, MJ
AF Cho, Yoonsu
   Shin, So-Youn
   Shin, Min-Jeong
TI Sarcopenic obesity is associated with lower indicators of psychological
   health and quality of life in Koreans
SO NUTRITION RESEARCH
LA English
DT Article
DE Sarcopenic obesity; Obesity; Psychological health; Depression; Quality
   of life
ID SKELETAL-MUSCLE MASS; NATIONAL-HEALTH; DEPRESSIVE SYMPTOMS; OLDER MEN;
   FUNCTIONAL IMPAIRMENT; EPIGENETIC REGULATION; INSULIN-RESISTANCE;
   METABOLIC SYNDROME; MAJOR DEPRESSION; GLOBAL MORTALITY
AB Sarcopenic obesity (SO) is known to contribute to morbidity and mortality from chronic diseases. However, there exists limited information regarding its effect on psychological health. The aim of this study was to evaluate association of SO with several indices of psychological health and quality of life (QoL) in Korean adults. This cross-sectional study was conducted with 11521 participants older than 20 years from the Korea National Health and Nutrition Examination Survey 2008-2011. Sarcopenic obesity was defined by a low appendicular skeletal muscle mass divided by body weight less than 1 standard deviation below the sex-specific mean for the young reference group, and by a high waist circumference of at least 90 cm for men and at least 85 cm for women. Psychological health status, including depressive symptoms, perceived stress, and suicidal ideation, as well as QoL, was assessed by a self-reporting questionnaire. Association between SO and psychological health status was assessed under a logistic regression model. After multivariate adjustment for demographics and lifestyle factors, SO was significantly associated with perceived stress (odds ratio, 1.24; 95% confidence interval, 1.07-1.44; P value = .004) and suicidal ideation (odds ratio, 1.26; 95% confidence interval, 1.06-1.50; P value = .010). In addition, SO was found to have a negative association with a range of QoL indicators. Interestingly, these association patterns were more significant in participants younger than 60 years. In conclusion, our results suggest that SO was associated with adverse psychological health and lower QoL more than body mass index-based general obesity. (C) 2015 Elsevier Inc. All rights reserved.
C1 [Cho, Yoonsu; Shin, Min-Jeong] Korea Univ, Dept Food & Nutr, Seoul 136703, South Korea.
   [Cho, Yoonsu; Shin, Min-Jeong] Korea Univ, Grad Sch, Dept Publ Hlth Sci, Seoul, South Korea.
   [Shin, So-Youn] Univ Bristol, MRC Integrat Epidemiol Unit, Bristol, Avon, England.
   [Shin, So-Youn] Univ Bristol, Sch Social & Community Med, Bristol, Avon, England.
   [Shin, So-Youn] Newcastle Univ, Inst Med Genet, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England.
   [Shin, Min-Jeong] Korea Univ, Guro Hosp, Seoul, South Korea.
C3 Korea University; Korea University; University of Bristol; University of
   Bristol; Newcastle University - UK; Korea University; Korea University
   Medicine (KU Medicine)
RP Shin, MJ (corresponding author), Korea Univ, Dept Food & Nutr, Seoul 136703, South Korea.
EM mjshin@korea.ac.kr
FU Basic Science Research Program through the National Research Foundation
   of Korea - Ministry of Education, Science and Technology
   [NRF-2013R1A1A2A10006101]; Post-Doctoral Research Fellowship from the
   Oak Foundation; National Research Foundation of Korea [21B20130012562]
   Funding Source: Korea Institute of Science & Technology Information
   (KISTI), National Science & Technology Information Service (NTIS)
FX This research was supported by Basic Science Research Program through
   the National Research Foundation of Korea funded by the Ministry of
   Education, Science and Technology (NRF-2013R1A1A2A10006101). SYS is
   supported by a Post-Doctoral Research Fellowship from the Oak
   Foundation. The authors declare there are no potential conflicts of
   interest.
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NR 63
TC 53
Z9 56
U1 0
U2 19
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0271-5317
EI 1879-0739
J9 NUTR RES
JI Nutr. Res.
PD MAY
PY 2015
VL 35
IS 5
BP 384
EP 392
DI 10.1016/j.nutres.2015.04.002
PG 9
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nutrition & Dietetics
GA CJ3MB
UT WOS:000355387000004
PM 25931418
DA 2025-06-11
ER

PT J
AU Cao, SS
   Shaw, EL
   Quarles, WR
   Sasaki, GY
   Dey, P
   Hodges, JK
   Pokala, A
   Zeng, M
   Bruno, RS
AF Cao, Sisi
   Shaw, Emily L.
   Quarles, William R.
   Sasaki, Geoffrey Y.
   Dey, Priyankar
   Hodges, Joanna K.
   Pokala, Avinash
   Zeng, Min
   Bruno, Richard S.
TI Daily Inclusion of Resistant Starch-Containing Potatoes in a Dietary
   Guidelines for Americans Dietary Pattern Does Not Adversely Affect
   Cardiometabolic Risk or Intestinal Permeability in Adults with Metabolic
   Syndrome: A Randomized Controlled Trial
SO NUTRIENTS
LA English
DT Article
DE cardiometabolic health; metabolic syndrome; potato; endotoxin;
   intestinal permeability
ID VASCULAR ENDOTHELIAL FUNCTION; HYPERGLYCEMIA-MEDIATED IMPAIRMENTS; CHAIN
   FATTY-ACIDS; POSTPRANDIAL HYPERGLYCEMIA; CARDIOVASCULAR-DISEASE;
   LIMITING INCREASES; INSULIN-RESISTANCE; OXIDATIVE STRESS; UNITED-STATES;
   DAIRY MILK
AB Poor diet quality influences cardiometabolic risk. Although potatoes are suggested to adversely affect cardiometabolic health, controlled trials that can establish causality are limited. Consistent with potatoes being rich in micronutrients and resistant starch, we hypothesized that their inclusion in a Dietary Guidelines for Americans (DGA)-based dietary pattern would improve cardiometabolic and gut health in metabolic syndrome (MetS) persons. In a randomized cross-over trial, MetS persons (n = 27; 32.5 +/- 1.3 year) consumed a DGA-based diet for 2 weeks containing potatoes (DGA + POTATO; 17.5 g/day resistant starch) or bagels (DGA + BAGEL; 0 g/day resistant starch) prior to completing oral glucose and gut permeability tests. Blood pressure, fasting glucose and insulin, and insulin resistance decreased (p < 0.05) from baseline regardless of treatment without any change in body mass. Oral glucose-induced changes in brachial artery flow-mediated dilation, nitric oxide homeostasis, and lipid peroxidation did not differ between treatment arms. Serum endotoxin AUC(0-120 min) and urinary lactulose/mannitol, but not urinary sucralose/erythritol, were lower in DGA + POTATO. Fecal microbiome showed limited between-treatment differences, but the proportion of acetate was higher in DGA + POTATO. Thus, short-term consumption of a DGA-based diet decreases cardiometabolic risk, and the incorporation of resistant starch-containing potatoes into a healthy diet reduces small intestinal permeability and postprandial endotoxemia.
C1 [Cao, Sisi; Shaw, Emily L.; Quarles, William R.; Sasaki, Geoffrey Y.; Dey, Priyankar; Hodges, Joanna K.; Pokala, Avinash; Zeng, Min; Bruno, Richard S.] Ohio State Univ, Human Nutr Program, Columbus, OH 43210 USA.
   [Dey, Priyankar] Thapar Inst Engn & Technol, Dept Biotechnol, Patiala 147004, Punjab, India.
C3 University System of Ohio; Ohio State University; Thapar Institute of
   Engineering & Technology
RP Bruno, RS (corresponding author), Ohio State Univ, Human Nutr Program, Columbus, OH 43210 USA.
EM cao.1142@osu.edu; emsh95@gmail.com; williamrquarles@gmail.com;
   sasaki.44@osu.edu; priyankar.dey@thapar.edu; hodges.466@osu.edu;
   pokala.2@osu.edu; zeng.670@osu.edu; bruno.27@osu.edu
RI Bruno, Richard/K-1930-2012; Cao, Sisi/ADV-0612-2022; Dey,
   Priyankar/AFE-4921-2022
OI Cao, Sisi/0000-0002-7413-295X; Zeng, Min/0009-0002-4575-0430; Hodges,
   PhD, Joanna Kalina/0000-0002-9187-9473; Pokala,
   Avinash/0000-0001-7817-2345; Quarles, William/0000-0001-8382-7051;
   Bruno, Richard/0000-0002-6772-2038; Dey, Priyankar/0000-0002-9513-425X
FU Alliance of Potato Research and Education; Ohio Agricultural Research
   and Development Center at Ohio State University; USDA-HATCH program
FX This work was supported by a grant to RSB from the Alliance of Potato
   Research and Education. The sponsor had no role in the design, conduct,
   analysis, or interpretation of the research. Support was also provided
   to RSB from the Ohio Agricultural Research and Development Center at
   Ohio State University and the USDA-HATCH program.
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NR 67
TC 13
Z9 13
U1 0
U2 6
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD APR
PY 2022
VL 14
IS 8
AR 1545
DI 10.3390/nu14081545
PG 21
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 0S3HM
UT WOS:000786168400001
PM 35458108
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Liu, Y
   Téllez-Rojo, M
   Sánchez, BN
   Ettinger, AS
   Osorio-Yáñez, C
   Solano, M
   Hu, H
   Peterson, KE
AF Liu, Yun
   Tellez-Rojo, Martha
   Sanchez, Brisa N.
   Ettinger, Adrienne S.
   Osorio-Yanez, Citlalli
   Solano, Maritsa
   Hu, Howard
   Peterson, Karen E.
TI Association between fluoride exposure and cardiometabolic risk in
   peripubertal Mexican children
SO ENVIRONMENT INTERNATIONAL
LA English
DT Article
DE Plasma fluoride; Cardiometabolic risk; Adiposity; Blood pressure;
   Insulin resistance
ID METABOLIC SYNDROME; INSULIN SENSITIVITY; LEAD-EXPOSURE; OXIDATIVE
   STRESS; PUBERTAL CHANGES; BONE METABOLISM; SODIUM-FLUORIDE; PRETERM
   BIRTH; PLASMA; WATER
AB Background: Several animal studies have suggested that fluoride exposure may increase the levels of cardio-metabolic risk factors, but little is known about whether fluoride exposure is associated with such risk in humans.
   Objectives: We examined the cross-sectional association between peripubertal exposure to fluoride and markers of cardiometabolic risk in 280 girls and 256 boys at age 10-18 years living in Mexico City.
   Methods: We measured plasma fluoride concentration using a microdiffusion method. We collected data on anthropometry including BMI, waist circumference (WC) and trunk fat percentage. We measured serum markers of cardiometabolic risk, including fasting glucose, insulin and lipids. All the indicators of outcome were converted to age- and sex-specific z-scores. We also calculated a summary cardiometabolic risk score for each participant. Multivariable linear regression models were used to examine these associations.
   Results: The geometric mean (95% confidence interval (CI)) of plasma fluoride was 0.21 mu mol/L (0.20, 0.23 mu mol/L) in the total sample. In girls, plasma fluoride concentrations were associated with higher z-scores for all the individual markers (except for lipids) and for the combined cardiometabolic risk score (risk score: beta=1.28, 95% CI: 0.57-2.00, p-sex interaction=0.02)), adjusting for covariates. No associations were found in boys.
   Conclusions: We found that higher peripubertal fluoride exposure at the levels observed in this study population was significantly associated with increased levels of cardiometabolic risk factors in Mexican girls but not boys. Future studies with a longitudinal design are needed to confirm our findings and further elucidate the role of fluoride in cardiometabolic risk.
C1 [Liu, Yun; Ettinger, Adrienne S.; Peterson, Karen E.] Univ Michigan, Sch Publ Hlth, Dept Nutr Sci, Ann Arbor, MI 48109 USA.
   [Tellez-Rojo, Martha; Osorio-Yanez, Citlalli; Solano, Maritsa] Natl Inst Publ Hlth, Nutr & Hlth Res, Cuernavaca, Morelos, Mexico.
   [Sanchez, Brisa N.] Univ Michigan, Sch Publ Hlth, Dept Biostat, Ann Arbor, MI 48109 USA.
   [Osorio-Yanez, Citlalli] Univ Nacl Autonoma Mexico, Inst Invest Biomed, Mexico City, DF, Mexico.
   [Hu, Howard] Univ Washington, Sch Publ Hlth, Dept Environm & Occupat Hlth Sci, Seattle, WA 98195 USA.
   [Hu, Howard] Univ Michigan, Sch Publ Hlth, Dept Environm Hlth Sci, Ann Arbor, MI 48109 USA.
C3 University of Michigan System; University of Michigan; Instituto
   Nacional de Salud Publica; University of Michigan System; University of
   Michigan; Universidad Nacional Autonoma de Mexico; University of
   Washington; University of Washington Seattle; University of Michigan
   System; University of Michigan
RP Téllez-Rojo, M (corresponding author), Ave Univ 655, Cuernavaca 62100, Mor, Mexico.
EM mmtellez@correo.insp.mx
RI Hu, Howard/AAV-5360-2021; Yáñez, Citlalli/AAH-3721-2020; Ettinger,
   Adrienne/ABF-6655-2020
OI Tellez Rojo, Martha/0000-0003-3322-3334; Hu, Howard/0000-0002-3676-2707;
   Ettinger, Adrienne S./0000-0002-0200-8677; Sanchez,
   Brisa/0000-0002-4824-7200
FU U.S. National Institutes of Health [R01ES021446, R01ES007821]; National
   Institute of Environmental Health Sciences/the U.S. Environmental
   Protection Agency [P01ES022844]; National Institute of Environmental
   Health Sciences [P20ES018171]; National Institute of Public
   Health/Ministry of Health of Mexico; National Institute of Diabetes and
   Digestive and Kidney Diseases [P30DK020572]; National Institute of
   Diabetes and Digestive and Kidney Diseases [P30DK020572] Funding Source:
   NIH RePORTER
FX We thank the study team and participants from ELEMENT study and thank
   ABC Hospital for providing facilities for this research. We also thank
   Christine Buckley and Prithvi Chandrappa for their work in the Indiana
   fluoride labs. The study was supported by the grants R01ES021446 and
   R01ES007821 from the U.S. National Institutes of Health, the grant
   P01ES022844 from the National Institute of Environmental Health
   Sciences/the U.S. Environmental Protection Agency, and the grant
   P20ES018171 from the National Institute of Environmental Health
   Sciences. This study was also supported and partially funded by the
   National Institute of Public Health/Ministry of Health of Mexico, and by
   the grant P30DK020572 (MDRC) from the National Institute of Diabetes and
   Digestive and Kidney Diseases.
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NR 56
TC 19
Z9 19
U1 0
U2 1
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0160-4120
EI 1873-6750
J9 ENVIRON INT
JI Environ. Int.
PD JAN
PY 2020
VL 134
AR 105302
DI 10.1016/j.envint.2019.105302
PG 8
WC Environmental Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology
GA JU0BE
UT WOS:000501344500010
PM 31726363
OA Green Accepted, gold
DA 2025-06-11
ER

PT J
AU Lautt, WW
   Ming, Z
   Legare, DJ
AF Lautt, W. Wayne
   Ming, Zhi
   Legare, Dallas J.
TI Attenuation of age- and sucrose-induced insulin resistance and syndrome
   X by a synergistic antioxidant cocktail: the AMIS syndrome and HISS
   hypothesis
SO CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
LA English
DT Article
DE HISS; AMIS; MIS; cardiometabolic risk; preventative; obesity; adiposity;
   diabetes; Samec
ID AUTONOMIC NERVOUS-SYSTEM; HEART-RATE-VARIABILITY; SENSITIVITY TEST RIST;
   NITRIC-OXIDE; METABOLIC SYNDROME; VISCERAL FAT; AUTOXIDATIVE
   GLYCOSYLATION; DIABETES-MELLITUS; OXIDATIVE STRESS; GLUTATHIONE
AB Absence of meal-induced insulin sensitization (AMIS) results in a predictable progression of dysfunctions, including postprandial hyperglycemia, compensatory hyperinsulinemia, resultant hyperlipidemia, increased oxidative stress, and obesity, progressing to syndrome X and diabetes. To one year of age, rats show a slow development of AMIS, but this can be potentiated by addition of a low-dose sucrose supplement to the diet. Provision of a synergistic antioxidant cocktail consisting of S-adenosylmethionine, vitamin E, and vitamin C (Samec) attenuates the rate and extent of development of AMIS in both normal aging animals and in aging animals on the sucrose diet. Adiposity, assessed from weighed regional fat masses and from bioelectrical impedance to estimate whole-body adiposity, correlated strongly with AMIS (r(2) = 0.7-0.8). Rats given the sucrose supplement had accelerated AMIS and developed fasting hyperinsulinemia and postprandial hyperglycemia, hyperlipidemia, hyperinsulinemia, and adiposity. Samec completely compensated for the negative impact of this sucrose supplement and attenuated development of the associated dysfunctions. AMIS is explained by the HISS (hepatic insulin-sensitizing substance) hypothesis, which is outlined in the paper.
C1 [Lautt, W. Wayne; Ming, Zhi; Legare, Dallas J.] Univ Manitoba, Dept Pharmacol & Therapeut, Fac Med, Winnipeg, MB R3E 0T6, Canada.
C3 University of Manitoba
RP Lautt, WW (corresponding author), Univ Manitoba, Dept Pharmacol & Therapeut, Fac Med, 753 McDermot Ave, Winnipeg, MB R3E 0T6, Canada.
EM wlautt@cc.umanitoba.ca
RI Legare, Dallas/AAC-3234-2021; Lautt, W./AAC-6106-2021
OI Lautt, W. Wayne/0000-0002-7239-1798
FU Canadian Institutes of Health Research; Manitoba Health Research Council
FX This study was funded by operating grants from the Canadian Institutes
   of Health Research and the Manitoba Health Research Council Regional
   Partnership Program. Manuscript preparation was by Karen Sanders. We
   acknowledge the excellent daily and long term care and monitoring of the
   animals provided by Gerry Nolette and the staff of Central Animal Care
   Services at the University of Manitoba. Related interests: W. W. Lautt
   and Z. Ming are inventors on a patent for the synergistic combination of
   S-adenosylmethionine, vitamin E, and vitamin C (Samec). Benac is
   licensed by the University of Manitoba to DiaMedica Inc., Winnipeg,
   Manitoba. Samec is licensed by the University of Manitoba to SciMar
   Ltd., Winnipeg, Manitoba.
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NR 66
TC 17
Z9 22
U1 0
U2 1
PU CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS
PI OTTAWA
PA 1200 MONTREAL ROAD, BUILDING M-55, OTTAWA, ON K1A 0R6, CANADA
SN 0008-4212
J9 CAN J PHYSIOL PHARM
JI Can. J. Physiol. Pharmacol.
PD MAR
PY 2010
VL 88
IS 3
BP 313
EP 323
DI 10.1139/Y09-130
PG 11
WC Pharmacology & Pharmacy; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Physiology
GA 590MC
UT WOS:000277229400015
PM 20393596
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Weihrauch-Blüher, S
   Wiegand, S
   Tittel, S
   Greber-Platzer, S
   Lanzinger, S
   Kamrath, C
   Minden, K
   Sengler, C
   Linke, S
   Büssenschütt, A
   Reschke, F
   Göldel, J
   Warschburger, P
   Holl, RW
AF Weihrauch-Blueher, Susann
   Wiegand, Susanna
   Tittel, Sascha
   Greber-Platzer, Susanne
   Lanzinger, Stefanie
   Kamrath, Clemens
   Minden, Kirsten
   Sengler, Claudia
   Linke, Sabine
   Buessenschuett, Antje
   Reschke, Felix
   Goeldel, Julia
   Warschburger, Petra
   Holl, Reinhard W.
TI Impact of the COVID-19 Pandemic on Psychosocial Distress in Adolescents
   with Obesity Compared to Those with Type 1 Diabetes: Results from the
   KICK-COVID Study in Germany
SO OBESITY FACTS
LA English
DT Article; Early Access
DE Chronic health condition; Obesity; Type 1 diabetes; Adolescents;
   COVID-19; Psychosocial distress
ID MENTAL-HEALTH; REPRESENTATIVE SAMPLE; CHILDREN; ANXIETY;
   STANDARDIZATION; DEPRESSION; GAD-7
AB Introduction: The aim of this study was to investigate the impact of the COVID-19 pandemic on psychosocial well-being in adolescents with obesity compared to those with type 1 diabetes. Methods: As part of the German KICK-COVID Study, adolescents aged 12-21 with overweight or obesity from the German/Austrian Adiposity Follow-up Registry (APV) completed well-being, anxiety, and depression questionnaires (WHO-5, GAD-7, PHQ-9) during routine visits amidst the COVID-19 pandemic. By multivariable linear regression models, adjusted for age, gender, and immigration background, the association between psychosocial distress, anthropometrics, and cardiometabolic risk factors was analyzed. Data were compared to those of youth with type 1 diabetes from the German/Austrian Diabetes Follow-up Registry (DPV) and normative values from the general population. Additionally, a mediation analysis examined the impact of loneliness on mental health through media consumption. Results: From June 2021 to September 2023, 235 adolescents from 6 German and 1 Austrian pediatric obesity centers were enrolled. Results were compared to 235 age- and gender-matched participants from the DPV registry (54.04% males; mean age 15.21 +/- 1.66 years) and normative values. Youth with type 1 diabetes were more anxious about their health risk, but distress factors were more pronounced in the APV group (p < 0.001). Girls from the APV group showed higher mental distress than boys across all applied questionnaires, but not for age, BMI-SDS, and migration background as predictors. Perception of loneliness correlated with poorer mental health outcomes, but it was not associated to media consumption. Comparisons with normative values revealed significantly higher depression and anxiety scores (p < 0.001) and lower well-being scores in the APV group (p < 0.01). Conclusions: Youth with obesity and diabetes experienced significant psychosocial distress during the COVID-19 pandemic. Disease-specific differences were observed on the level of single items: Adolescents with type 1 diabetes expressed heightened concern about their health risks, while those with obesity reported lower self-esteem, increased suicidal thoughts, and fluctuating appetite. Female gender appeared to pose an additional risk factor. Media consumption was notably higher in the APV cohort. Healthcare providers should be vigilant regarding psychological comorbidities in youth with chronic conditions, particularly during periods of heightened stress.
C1 [Weihrauch-Blueher, Susann] Univ Med Halle, Clin Pediat 1, Pediat Endocrinol & Diabetol, Halle, Saale, Germany.
   [Wiegand, Susanna] Charite Univ Med Berlin, Ctr Social Pediat Care, Dept Pediat Endocrinol & Diabetol, Berlin, Germany.
   [Wiegand, Susanna] Free Univ Berlin, Berlin, Germany.
   [Wiegand, Susanna] Humboldt Univ, Berlin, Germany.
   [Tittel, Sascha; Lanzinger, Stefanie; Holl, Reinhard W.] Ulm Univ, Inst Epidemiol & Med Biometry, CAQM, Ulm, Germany.
   [Tittel, Sascha; Lanzinger, Stefanie; Holl, Reinhard W.] German Ctr Diabet Res DZD, Neuherberg, Germany.
   [Greber-Platzer, Susanne] Med Univ Vienna, Dept Pediat & Adolescent Med Allergol & Endocrinol, Div Pediat Pulmonol, Vienna, Austria.
   [Kamrath, Clemens] Univ Freiburg, Ctr Child & Adolescent Med, Div Pediat Endocrinol & Diabetol, Freiburg, Germany.
   [Minden, Kirsten; Sengler, Claudia] German Rheumatism Res Ctr DRFZ, Program Area Epidemiol, Berlin, Germany.
   [Minden, Kirsten] Charite Univ MedBerlin, Dept Pediat Resp Med Immunol & Crit Care Med, Berlin, Germany.
   [Linke, Sabine] Childrens Hosp Wilhelmsstift Hamburg, Hamburg, Germany.
   [Buessenschuett, Antje] ZABS eV Ctr Obes Educ, Bremen, Germany.
   [Reschke, Felix] Childrens Hosp BULT, Ctr Pediat Diabetol Endocrinol & Metab, Hannover, Germany.
   [Goeldel, Julia; Warschburger, Petra] Univ Potsdam, Dept Psychol, Counseling Psychol, Potsdam, Germany.
C3 Berlin Institute of Health; Free University of Berlin; Humboldt
   University of Berlin; Charite Universitatsmedizin Berlin; Free
   University of Berlin; Humboldt University of Berlin; Ulm University;
   German Center for Diabetes Research (DZD); Medical University of Vienna;
   University of Freiburg; Leibniz Association; Deutsches
   Rheuma-Forschungszentrum (DRFZ); University of Potsdam
RP Wiegand, S (corresponding author), Charite Univ Med Berlin, Ctr Social Pediat Care, Dept Pediat Endocrinol & Diabetol, Berlin, Germany.; Wiegand, S (corresponding author), Free Univ Berlin, Berlin, Germany.; Wiegand, S (corresponding author), Humboldt Univ, Berlin, Germany.
EM susanna.wiegand@charite.de
RI Kamrath, Clemens/GWR-0507-2022; Minden, Kirsten/LFV-1902-2024;
   Greber-Platzer, Susanne/AAT-1972-2021
OI Kamrath, Clemens/0000-0002-8241-4105
FU German Research Foundation [HO 3228/2-1, MI 2760/1-1, WA 1143/18-1];
   Innovative Medicines Initiative 2 Joint Undertaking [875534]; European
   Union; German Federal Ministry for Education and Research within the
   German Centre for Diabetes Research (DZD) [82DZD14E03]; German Diabetes
   Foundation (DDS) [FP-0438e2021]
FX This study is part of the joint project "A prospective analysis of the
   long-term impact of the COVID-19 pandemic on well-being and healthcare
   among children with a high-risk chronic condition and their families,"
   funded by the German Research Foundation <EM><STRONG>
   </STRONG></EM>(Grant No: HO 3228/2-1, MI 2760/1-1, WA 1143/18-1). This
   manuscript is part of the Stratification of Obesity Phenotypes to
   Optimize Future Obesity Therapy (SOPHIA) project (https//:
   imisophia.eu). SOPHIA has received funding from the Innovative Medicines
   Initiative 2 Joint Undertaking under Grant agreement No. 875534. This
   joint undertaking is supported by the European Union's Horizon 2020
   Research and Innovation Program and EFPIA and T1D Exchange, JDRF, and
   Obesity Action Coalition. DPV is supported through the German Federal
   Ministry for Education and Research within the German Centre for
   Diabetes Research (DZD, Grant No. 82DZD14E03). Further financial support
   was received by the German Diabetes Foundation (DDS, Grant No.
   FP-0438e2021. The funding organizations had no role in design, data
   collection, data analysis, and reporting of this study.
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NR 54
TC 0
Z9 0
U1 2
U2 2
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1662-4025
EI 1662-4033
J9 OBESITY FACTS
JI Obes. Facts
PD 2025 FEB 17
PY 2025
DI 10.1159/000542756
EA FEB 2025
PG 14
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA 1OL3Y
UT WOS:001469860600001
PM 39961287
OA gold
DA 2025-06-11
ER

PT J
AU Hanna, MR
   Caspi, A
   Houts, RM
   Moffitt, TE
   Torvik, FA
AF Hanna, Matthew R.
   Caspi, Avshalom
   Houts, Renate M.
   Moffitt, Terrie E.
   Torvik, Fartein Ask
TI Co-occurrence between mental disorders and physical diseases: a study of
   nationwide primary-care medical records
SO PSYCHOLOGICAL MEDICINE
LA English
DT Article
DE comorbidity; health registry data; integrated healthcare; mental
   disorders; mental physical comorbidity; nationwide cohort;
   physical-health conditions; primary care
ID CORONARY-HEART-DISEASE; PREMATURE MORTALITY; CARDIOVASCULAR-DISEASE;
   METABOLIC SYNDROME; EXCESS MORTALITY; HEALTH-CARE; RISK-FACTOR;
   DEPRESSION; SCHIZOPHRENIA; PEOPLE
AB Background. Mental disorders and physical-health conditions frequently co-occur, impacting treatment outcomes. While most prior research has focused on single pairs of mental disorders and physical-health conditions, this study explores broader associations between multiple mental disorders and physical-health conditions. Methods. Using the Norwegian primary-care register, this population-based cohort study encompassed all 2 203 553 patients born in Norway from January 1945 through December 1984, who were full-time residents from January 2006 until December 2019 (14 years; 363 million person-months). Associations between seven mental disorders (sleep disturbance, anxiety, depression, acute stress reaction, substance-use disorders, phobia/compulsive disorder, psychosis) and 16 physical-health conditions were examined, diagnosed according to the International Classification of Primary Care. Results. Of 112 mental-disorder/physical-health condition pairs, 96% of associations yielded positive and significant ORs, averaging 1.41 and ranging from 1.05 (99.99% CI 1.00-1.09) to 2.38 (99.99% CI 2.30-2.46). Across 14 years, every mental disorder was associated with multiple different physical-health conditions. Across 363 million person-months, having any mental disorder was associated with increased subsequent risk of all physical-health conditions (HRs:1.40 [99.99% CI 1.35-1.45] to 2.85 [99.99% CI 2.81-2.89]) and vice versa (HRs:1.56 [99.99% CI 1.54-1.59] to 3.56 [99.99% CI 3.54-3.58]). Associations were observed in both sexes, across age groups, and among patients with and without university education. Conclusions. The breadth of associations between virtually every mental disorder and physical-health condition among patients treated in primary care underscores a need for integrated mental and physical healthcare policy and practice. This remarkable breadth also calls for research into etiological factors and underlying mechanisms that can explain it.
C1 [Hanna, Matthew R.; Caspi, Avshalom; Houts, Renate M.; Moffitt, Terrie E.] Duke Univ, Dept Psychol & Neurosci, Durham, NC 27708 USA.
   [Caspi, Avshalom; Moffitt, Terrie E.] Duke Univ, Dept Psychiat &Behavioral Sci, Sch Med, Durham, NC USA.
   [Caspi, Avshalom; Moffitt, Terrie E.] Kings Coll London, Inst Psychiat Psychol & Neurosci, London, England.
   [Caspi, Avshalom; Moffitt, Terrie E.; Torvik, Fartein Ask] Univ Oslo, Promenta Res Ctr, Oslo, Norway.
   [Torvik, Fartein Ask] Norwegian Inst Publ Hlth, Ctr Fertil & Hlth, Oslo, Norway.
C3 Duke University; Duke University; University of London; King's College
   London; University of Oslo; Norwegian Institute of Public Health (NIPH)
RP Hanna, MR (corresponding author), Duke Univ, Dept Psychol & Neurosci, Durham, NC 27708 USA.
EM matt.hanna@duke.edu
RI Houts, Renate/AAC-5304-2019; caspi, avshalom/ACB-7376-2022; Moffitt,
   Terrie/D-5295-2011; caspi, avshalom/D-5294-2011
OI Moffitt, Terrie/0000-0002-8589-6760; Torvik, Fartein
   Ask/0000-0003-3984-5978; caspi, avshalom/0000-0003-0082-4600; Houts,
   Renate/0000-0002-1518-2631; Hanna, Matthew/0009-0001-0937-1946
FU Research Council of Norway [300668, 262700]; US-National Institute on
   Aging [R01AG032282, P30-AG034424]; US-National Institute of Child Health
   and Human Development [P2C-HD065563]; UK Medical Research Council
   [MR/X021149/1]
FX This work is part of the REMENTA project and was supported by the
   Research Council of Norway (#300668). This work was partly supported by
   the Research Council of Norway through its Centres of Excellence funding
   scheme, project number 262700. Additional support was provided by grants
   from the US-National Institute on Aging(R01AG032282, P30-AG034424),
   US-National Institute of Child Health and Human Development
   (P2C-HD065563), and the UK Medical Research Council (MR/X021149/1). The
   funders of the study had no role in study design, data collection, data
   analysis, data interpretation, or writing of the report.
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NR 68
TC 2
Z9 2
U1 3
U2 5
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0033-2917
EI 1469-8978
J9 PSYCHOL MED
JI Psychol. Med.
PD NOV
PY 2024
VL 54
IS 15
BP 4274
EP 4286
DI 10.1017/S0033291724002575
EA NOV 2024
PG 13
WC Psychology, Clinical; Psychiatry; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA W2U6U
UT WOS:001358026500001
PM 39552403
OA hybrid
DA 2025-06-11
ER

PT J
AU Gibson-Smith, D
   Bot, M
   Brouwer, IA
   Visser, M
   Giltay, EJ
   Penninx, BWJH
AF Gibson-Smith, Deborah
   Bot, Mariska
   Brouwer, Ingeborg A.
   Visser, Marjolein
   Giltay, Erik J.
   Penninx, Brenda W. J. H.
TI Association of food groups with depression and anxiety disorders
SO EUROPEAN JOURNAL OF NUTRITION
LA English
DT Article
DE Mediterranean diet; Depression; Anxiety; Diet quality
ID DIETARY PATTERNS; METABOLIC SYNDROME; FISH CONSUMPTION; RISK-FACTOR;
   METAANALYSIS; SYMPTOMS; ADHERENCE; LIFE; POPULATION; INVENTORY
AB Purpose Adherence to the Mediterranean diet has been associated with fewer depressive symptoms, however, it is unknown whether this is attributed to some or to all components. We examined the association between the individual food groups of the Mediterranean Diet Score (MDS), in isolation and in combination, with depression and anxiety (symptom severity and diagnosis). Methods Data from 1634 adults were available from the Netherlands Study of Depression and Anxiety. Eleven energy-adjusted food groups were created from a 238-item food frequency questionnaire. In regression analysis, these were associated in isolation and combination with (1) depressive and anxiety disorders (established with the Composite International Diagnostic Interview) (current disorder n = 414), and (2) depression and anxiety severity [measured with the Inventory of Depressive Symptomatology (IDS), the Beck Anxiety Inventory (BAI) and the Fear Questionnaire (FEAR)]. Results Overall, the MDS score shows the strongest relationships with depression/anxiety [Diagnosis: odds ratio (OR) 0.77 per SD, 95% confidence interval (95% CI) 0.66-0.90, IDS: standardised betas (beta) - 0.13, 95% CI - 0.18, - 0.08] and anxiety (BAI: beta - 0.11, 95% CI - 0.16, - 0.06, FEAR: beta - 0.08, 95% CI - 0.13, - 0.03). Greater consumption of non-refined grains and vegetables was associated with lower depression and anxiety severity, whilst being a non-drinker was associated with higher symptom severity. Higher fruit and vegetable intake was associated with lower fear severity. Non-refined grain consumption was associated with lower odds and being a non-drinker with greater odds of current depression/anxiety disorders compared to healthy controls, these associations persisted after adjustment for other food groups (OR 0.82 per SD, 95% CI 0.71-0.96, OR 1.26 per SD 95% CI 1.08-1.46). Conclusion We can conclude that non-refined grains, vegetables and alcohol intake appeared to be the driving variables for the associated the total MDS score and depression/anxiety. However, the combined effect of the whole diet remains important for mental health. It should be explored whether an increase consumption of non-refined grains and vegetables may help to prevent or reduce depression and anxiety.
C1 [Gibson-Smith, Deborah; Bot, Mariska; Penninx, Brenda W. J. H.] Amsterdam UMC, Dept Psychiat, Amsterdam Publ Hlth Res Inst, Amsterdam, Netherlands.
   [Brouwer, Ingeborg A.; Visser, Marjolein] Vrije Univ Amsterdam, Fac Sci, Amsterdam Publ Hlth Res Inst, Dept Hlth Sci, Amsterdam, Netherlands.
   [Giltay, Erik J.] Leiden Univ, Dept Psychiat, Med Ctr, Leiden, Netherlands.
C3 Vrije Universiteit Amsterdam; University of Amsterdam; Vrije
   Universiteit Amsterdam; Leiden University; Leiden University Medical
   Center (LUMC); Leiden University - Excl LUMC
RP Bot, M (corresponding author), Amsterdam UMC, Dept Psychiat, Amsterdam Publ Hlth Res Inst, Amsterdam, Netherlands.
EM m.bot@ggzingeest.nl
RI Giltay, Erik/AAL-9948-2021; Brouwer, Inge/K-8455-2013; Visser,
   Marjolein/AAP-3224-2020; Gibson-Smith, Deborah/B-4495-2016; Penninx,
   Brenda WJH/S-7627-2017
OI Visser, Marjolein/0000-0002-5136-298X; Brouwer,
   Ingeborg/0000-0002-8762-382X; Gibson-Smith, Deborah/0000-0002-7552-500X;
   Penninx, Brenda WJH/0000-0001-7779-9672; Giltay, Erik
   J./0000-0001-8874-2292
FU EU FP7 [613598] Funding Source: Medline; ZonMw [10-000-1002] Funding
   Source: Medline
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NR 63
TC 67
Z9 71
U1 2
U2 36
PU SPRINGER HEIDELBERG
PI HEIDELBERG
PA TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY
SN 1436-6207
EI 1436-6215
J9 EUR J NUTR
JI Eur. J. Nutr.
PD MAR
PY 2020
VL 59
IS 2
BP 767
EP 778
DI 10.1007/s00394-019-01943-4
PG 12
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nutrition & Dietetics
GA KS7LG
UT WOS:000518487600028
PM 30945032
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Lamers, F
   Milaneschi, Y
   Vinkers, CH
   Schoevers, RA
   Giltay, EJ
   Penninx, BWJH
AF Lamers, Femke
   Milaneschi, Yuri
   Vinkers, Christiaan H.
   Schoevers, Robert A.
   Giltay, Erik J.
   Penninx, Brenda W. J. H.
TI Depression profilers and immuno-metabolic dysregulation: Longitudinal
   results from the NESDA study
SO BRAIN BEHAVIOR AND IMMUNITY
LA English
DT Article
DE Inflammation; Metabolic syndrome; Depression; Heterogeneity; Profiling
ID C-REACTIVE PROTEIN; ANXIOUS DISTRESS SPECIFIER; SUBSTANCE USE DISORDERS;
   INFLAMMATORY MARKERS; CHILDHOOD TRAUMA; WEIGHT CHANGE; LARGE COHORT;
   ANXIETY; ASSOCIATION; METAANALYSIS
AB Background: Major depressive disorder (MDD) is linked to higher cardio-metabolic comorbidity that may in part be due to the low-grade inflammation and poorer metabolic health observed in MDD. Heterogeneity of MDD is however large, and immune-inflammatory and metabolic dysregulation is present in only part of the MDD cases. We examined the associations of four depression dimensional profilers (atypical energy-related symptom dimension, melancholic symptom dimension, childhood trauma severity, and anxious distress symptom dimension) with immuno-metabolic outcomes, both cross-sectionally and longitudinally.
   Methods: Three waves covering a 6-year follow-up (>7000 observations) of the Netherlands Study of Depression and Anxiety (NESDA) were used. Depression profilers were based on the Inventory of Depressive Symptomatology, the Beck Anxiety Inventory, and the Childhood Trauma index. An inflammatory index (based on IL-6 and CRP), a metabolic syndrome index (based on the five metabolic syndrome components), and a combination of these two indices were constructed. Mixed models were used for cross-sectional and longitudinal models, controlling for covariates.
   Results: Of the four depression profilers, only the atypical, energy-related symptom dimension showed robust associations with higher scores on the inflammatory, metabolic syndrome and combined inflammatory-metabolic indexes cross-sectionally, as well as at follow-up. The melancholic symptom dimension was associated with lower scores on the metabolic syndrome index both cross-sectionally and longitudinally.
   Conclusion: The atypical energy-related symptom dimension was linked to poorer immune-inflammatory and metabolic health, while the melancholic symptom dimension was linked to relatively better metabolic health. Persons with high atypical energy-related symptom burden, representing an immuno-metabolic depression, may be the most important group to target in prevention programs for cardiometabolic disease, and may benefit most from treatments targeting immuno-metabolic pathways.
C1 [Lamers, Femke; Milaneschi, Yuri; Vinkers, Christiaan H.; Penninx, Brenda W. J. H.] Vrije Univ Amsterdam, Amsterdam UMC, Dept Psychiat, Amsterdam Publ Hlth Res Inst, Amsterdam, Netherlands.
   [Lamers, Femke; Milaneschi, Yuri; Vinkers, Christiaan H.; Penninx, Brenda W. J. H.] Amsterdam Neurosci, Amsterdam, Netherlands.
   [Vinkers, Christiaan H.] Amsterdam Neurosci, Amsterdam UMC, Dept Anat & Neurosiences, Amsterdam, Netherlands.
   [Schoevers, Robert A.] Univ Groningen, Univ Med Ctr Groningen, Dept Psychiat, Groningen, Netherlands.
   [Giltay, Erik J.] Leiden Univ, Dept Psychiat, Med Ctr, Leiden, Netherlands.
C3 University of Amsterdam; Vrije Universiteit Amsterdam; Vrije
   Universiteit Amsterdam; Vrije Universiteit Amsterdam; University of
   Amsterdam; University of Groningen; Leiden University - Excl LUMC;
   Leiden University; Leiden University Medical Center (LUMC)
RP Lamers, F (corresponding author), Vrije Univ Amsterdam, Amsterdam UMC, Dept Psychiat, Amsterdam Publ Hlth Res Inst, Amsterdam, Netherlands.; Lamers, F (corresponding author), Amsterdam Neurosci, Amsterdam, Netherlands.
EM f.lamers@amsterdamumc.nl
RI Giltay, Erik/AAL-9948-2021; Vinkers, Christiaan/AAV-1720-2020; Lamers,
   Femke/G-5161-2012; Penninx, Brenda WJH/S-7627-2017
OI Penninx, Brenda WJH/0000-0001-7779-9672; Giltay, Erik
   J./0000-0001-8874-2292; Milaneschi, Yuri/0000-0002-3697-6617; Schoevers,
   Robert A/0000-0003-0760-9866; Vinkers, Christiaan/0000-0003-3698-0744
FU Netherlands Organisation for Health Research and Development (ZonMw)
   [10-0001002]; Amsterdam University Medical Centers (location VUmc); GGZ
   inGeest; Leiden University Medical Center; Leiden University; GGZ
   Rivierduinen; University Medical Center Groningen; University of
   Groningen; Lentis; GGZ Friesland; GGZ Drenthe; Rob Giel
   Onderzoekscentrum; NWO [91811602]; Janssen Research & Development, LLC,
   Titusville, NJ, USA
FX The infrastructure for the NESDA study (www.nesda.nl) is funded through
   the Geestkracht program of the Netherlands Organisation for Health
   Research and Development (ZonMw, grant number 10-0001002) and financial
   contributions by participating universities and mental health care
   organizations (Amsterdam University Medical Centers (location VUmc), GGZ
   inGeest, Leiden University Medical Center, Leiden University, GGZ
   Rivierduinen, University Medical Center Groningen, University of
   Groningen, Lentis, GGZ Friesland, GGZ Drenthe, Rob Giel
   Onderzoekscentrum). Data analyses and biomarker assays were partly
   funded through NWO funding (VICI, Grant No. 91811602) and through grant
   support from Janssen Research & Development, LLC, Titusville, NJ, USA.
   The funders did not have direct access to the data and were not involved
   in the conduct of the data collection, management and analyses.
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NR 68
TC 81
Z9 84
U1 0
U2 7
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0889-1591
EI 1090-2139
J9 BRAIN BEHAV IMMUN
JI Brain Behav. Immun.
PD AUG
PY 2020
VL 88
BP 174
EP 183
DI 10.1016/j.bbi.2020.04.002
PG 10
WC Immunology; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Immunology; Neurosciences & Neurology; Psychiatry
GA MU5JL
UT WOS:000555709500030
PM 32272220
OA Green Published, hybrid, Green Submitted
DA 2025-06-11
ER

PT J
AU Nakao, A
   Toyoda, Y
   Sharma, P
   Evans, M
   Guthrie, N
AF Nakao, Atsunori
   Toyoda, Yoshiya
   Sharma, Prachi
   Evans, Malkanthi
   Guthrie, Najla
TI Effectiveness of Hydrogen Rich Water on Antioxidant Status of Subjects
   with Potential Metabolic Syndrome-An Open Label Pilot Study
SO JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION
LA English
DT Article
DE hydrogen; drinking water; magnesium; oxidative stress; metabolic
   syndrome
ID OXIDATIVE STRESS; VITAMIN-C; SERUM; ASSOCIATION; BILIRUBIN; HEME; RISK
AB Metabolic syndrome is characterized by cardiometabolic risk factors that include obesity, insulin resistance, hypertension and dyslipidemia. Oxidative stress is known to play a major role in the pathogenesis of metabolic syndrome. The objective of this study was to examine the effectiveness of hydrogen rich water (1.5-2 L/day) in an open label, 8-week study on 20 subjects with potential metabolic syndrome. Hydrogen rich water was produced, by placing a metallic magnesium stick into drinking water (hydrogen concentration; 0.55-0.65 mM), by the following chemical reaction; Mg + 2H(2)O -> Mg (OH)(2) + H-2. The consumption of hydrogen rich water for 8 weeks resulted in a 39% increase (p<0.05) in antioxidant enzyme superoxide dismutase (SOD) and a 43% decrease (p<0.05) in thiobarbituric acid reactive substances (TBARS) in urine. Further, subjects demonstrated an 8% increase in high density lipoprotein (HDL)-cholesterol and a 13% decrease in total cholesterol/HDL-cholesterol from baseline to week 4. There was no change in fasting glucose levels during the 8 week study. In conclusion, drinking hydrogen rich water represents a potentially novel therapeutic and preventive strategy for metabolic syndrome. The portable magnesium stick was a safe, easy and effective method of delivering hydrogen rich water for daily consumption by participants in the study.
C1 [Nakao, Atsunori; Toyoda, Yoshiya] Univ Pittsburgh, Med Ctr, Dept Surg, Heart Lung & Esophageal Surg Inst, Pittsburgh, PA 15213 USA.
   [Sharma, Prachi; Evans, Malkanthi; Guthrie, Najla] KGK Synergize Inc, London, ON N6A 5R8, Canada.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE); University
   of Pittsburgh
RP Nakao, A (corresponding author), Univ Pittsburgh, Med Ctr, Dept Surg, Heart Lung & Esophageal Surg Inst, Pittsburgh, PA 15213 USA.
EM anakao@imap.pitt.edu
FU Friendear Inc.
FX We would like to thank the volunteers of this study for their
   willingness and diligence in complying with the protocol. This study was
   managed by KGK Synergize Inc. London, ON, Canada, under the supervision
   of the medical directors, David Crowley, MD and Dale Wilson, MD.
   Statistical guidance and analysis was provided by Larry Stitt, Assistant
   Director of the Biostatistical Support Unit, University of Western
   Ontario, London, ON, Canada. We acknowledge the technical contribution
   of Joshua Baisley and thank Sonya Barss for overseeing the conduct of
   the study. This study was supported by Friendear Inc. (De-coupage Minami
   Aoyama 4F, 5-10-13 Minami Aoyama, Minato-ku, Tokyo 107-0062, Japan).
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NR 30
TC 237
Z9 275
U1 4
U2 38
PU JOURNAL CLINICAL BIOCHEMISTRY & NUTRITION
PI KYOTO
PA KYOTO PREFECTURAL UNIV MED, GRAD SCH MEDICAL SCIENCE, DEPT MOLECULAR
   GASTROENTEROLOGY & HEPATOLOGY, KYOTO, 602-8566, JAPAN
SN 0912-0009
EI 1880-5086
J9 J CLIN BIOCHEM NUTR
JI J. Clin. Biochem. Nutr.
PD MAR
PY 2010
VL 46
IS 2
BP 140
EP 149
DI 10.3164/jcbn.09-100
PG 10
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA 573ZR
UT WOS:000275958700007
PM 20216947
OA Bronze, Green Published
DA 2025-06-11
ER

PT J
AU Ehrlich, KB
   Chen, E
   Yu, TY
   Miller, GE
   Brody, GH
AF Ehrlich, Katherine B.
   Chen, Edith
   Yu, Tianyi
   Miller, Gregory E.
   Brody, Gene H.
TI Exposure to Parental Depression in Adolescence and Risk for Metabolic
   Syndrome in Adulthood
SO CHILD DEVELOPMENT
LA English
DT Article
ID NUTRITION EXAMINATION SURVEY; MATERNAL DEPRESSION; SELF-REGULATION;
   HEALTH BEHAVIOR; NATIONAL-HEALTH; STRESS; MODEL; CHILDHOOD;
   PSYCHOPATHOLOGY; INFLAMMATION
AB The psychosocial consequences of living with a depressed parent have been well characterized. Less well known, however, is how this exposure is predictive of later physical health problems. The present study evaluated how parental depression across youths' adolescence (ages 11-18) was associated with youth metabolic syndrome at age 25 (n = 391). Youth self-regulation and health behaviors were considered as possible moderators of the link between parental depression and youth metabolic syndrome. Analyses revealed that parental depression in adolescence was associated with a composite score reflecting metabolic syndrome components in early adulthood. Furthermore, self-regulation and health behaviors moderated this link, such that links between parental depression and the metabolic syndrome existed only for youth with low self-regulation or unhealthy behaviors.
C1 [Ehrlich, Katherine B.; Yu, Tianyi; Brody, Gene H.] Univ Georgia, Athens, GA 30602 USA.
   [Chen, Edith; Miller, Gregory E.] Northwestern Univ, Evanston, IL 60208 USA.
C3 University System of Georgia; University of Georgia; Northwestern
   University
RP Ehrlich, KB (corresponding author), Univ Georgia, Dept Psychol, Athens, GA 30602 USA.
EM kehrlich@uga.edu
RI Ehrlich, Katherine/AAF-4687-2020
OI Miller, Gregory/0000-0002-7217-1082; Yu, Tianyi/0000-0003-3087-1504
FU National Institute on Child Health and Human Development [R01HD030588];
   National Institute on Drug Abuse [P30DA027827]
FX This research was supported by Award R01HD030588 from the National
   Institute on Child Health and Human Development and Award P30DA027827
   from the National Institute on Drug Abuse.
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TC 7
Z9 7
U1 0
U2 13
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0009-3920
EI 1467-8624
J9 CHILD DEV
JI Child Dev.
PD JUL
PY 2019
VL 90
IS 4
BP 1272
EP 1285
DI 10.1111/cdev.13003
PG 14
WC Psychology, Educational; Psychology, Developmental
WE Social Science Citation Index (SSCI)
SC Psychology
GA IJ5RB
UT WOS:000475959400025
PM 29171667
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Hassani, FV
   Shirani, K
   Hosseinzadeh, H
AF Hassani, Faezeh Vahdati
   Shirani, Kobra
   Hosseinzadeh, Hossein
TI Rosemary (Rosmarinus officinalis) as a potential therapeutic
   plant in metabolic syndrome: a review
SO NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
LA English
DT Review
DE Metabolic syndrome; Rosmarinus officinalis; Cardiovascular disease;
   Obesity; Diabetes
ID HORMONE-SENSITIVE LIPASE; LOW-DENSITY-LIPOPROTEIN; CARNOSIC ACID
   PREVENTS; FACTOR-KAPPA-B; ESSENTIAL OIL; PHENOLIC DITERPENES;
   INSULIN-RESISTANCE; LIPID-PEROXIDATION; DIABETES-MELLITUS; OXIDATIVE
   STRESS
AB Metabolic syndrome is defined by a constellation of complex coexisting cardiometabolic risk factors such as hyperglycemia, dyslipidemia, inflammation, abdominal obesity, coagulopathies, and hypertension that raise the risk of diabetes mellitus and cardiovascular disease. Recently, there has been an increasing interest in the use of herbs and natural compounds in prevention and treatment of diseases and a large number of published articles have focused on this issue. Rosmarinus officinalis L. or rosemary (Lamiaceae) is a rich source of phenolic phytochemicals having significant anti-oxidant, anti-inflammatory, hypoglycemic, hypolipidemic, hypotensive, anti-atherosclerotic, anti-thrombotic, hepatoprotective, and hypocholesterolemic effects. The purpose of this review is to highlight the interesting pharmacological effects of rosemary, and its active compounds, and the related mechanisms in the management of metabolic syndrome that are documented in in vitro and in vivo studies.
C1 [Hassani, Faezeh Vahdati; Shirani, Kobra] Mashhad Univ Med Sci, Sch Pharm, Dept Pharmacodynam & Toxicol, Mashhad, Iran.
   [Hosseinzadeh, Hossein] Mashhad Univ Med Sci, Sch Pharm, Dept Pharmacodynam & Toxicol, Pharmaceut Res Ctr, Mashhad, Iran.
C3 Mashhad University of Medical Sciences; Mashhad University of Medical
   Sciences
RP Hosseinzadeh, H (corresponding author), Mashhad Univ Med Sci, Sch Pharm, Dept Pharmacodynam & Toxicol, Pharmaceut Res Ctr, Mashhad, Iran.
EM HosseinzadehH@mums.ac.ir
RI shirani, kobra/AAH-5027-2021; Hosseinzadeh, Hossein/F-3013-2010
OI Hosseinzadeh, Hossein/0000-0002-3483-851X
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NR 101
TC 109
Z9 112
U1 3
U2 72
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0028-1298
EI 1432-1912
J9 N-S ARCH PHARMACOL
JI Naunyn-Schmiedebergs Arch. Pharmacol.
PD SEP
PY 2016
VL 389
IS 9
BP 931
EP 949
DI 10.1007/s00210-016-1256-0
PG 19
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA DT3TN
UT WOS:000381404000001
PM 27178264
DA 2025-06-11
ER

PT J
AU Ardekani, AM
   Vahdat, S
   Hojati, A
   Moradi, H
   Tousi, AZ
   Ebrahimzadeh, F
   Farhangi, MA
AF Ardekani, Abnoos Mokhtari
   Vahdat, Sahar
   Hojati, Ali
   Moradi, Hadi
   Tousi, Ayda Zahiri
   Ebrahimzadeh, Farnoosh
   Farhangi, Mahdieh Abbasalizad
TI Evaluating the association between the Mediterranean-DASH Intervention
   for Neurodegenerative Delay (MIND) diet, mental health, and
   cardio-metabolic risk factors among individuals with obesity
SO BMC ENDOCRINE DISORDERS
LA English
DT Article
DE MIND diet; Mental health; Cardio-metabolic risk; Diet
ID MELANOCYTE-STIMULATING-HORMONE; CARDIOMETABOLIC RISK; CARDIOVASCULAR
   RISK; COGNITIVE DECLINE; PHYSICAL-ACTIVITY; PLASMA-LEVELS; MECHANISMS;
   ADHERENCE; WEIGHT; IMPACT
AB BackgroundSeveral previous investigations have examined the brain-protective role of the Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet. However, more knowledge is needed about the MIND diet's other favorable impacts. The purpose of this study was to examine the relationship between the MIND diet, mental health, and metabolic markers in individuals with obesity.MethodsIn this cross-sectional study, we included 339 individuals with obesity (BMI >= 30 kg/m(2)) aged 20-50 years. We utilized a semi-quantitative Food Frequency Questionnaire (FFQ), we assessed dietary intake, including 168 food items, and calculated the value of MIND. Metabolic syndrome (MetS) was defined according to the National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATP III) guidelines. We assessed biochemical parameters using Enzymatic methods. Blood pressure and body composition were also determined.ResultsHigher tertiles of the MIND diet score were associated with significantly higher energy intake, macronutrients, and brain-healthy food intakes (P < 0.001). Among the brain-unhealthy foods, only the intake of sweets and pastries was significantly lower in the highest versus lowest MIND tertiles. We also observed lower odds of stress (P < 0.05) and higher insulin sensitivity (P < 0.05) in the highest versus lowest MIND diet tertiles. We witnessed no significant changes in other parameters.ConclusionLower stress levels and higher insulin sensitivity independent of some confounders like age, BMI, sex, and physical activity were associated with the highest tertile of MIND diet score.
C1 [Ardekani, Abnoos Mokhtari] Kerman Univ Med Sci, Inst Basic & Clin Physiol Sci, Endocrinol & Metab Res Ctr, Kerman, Iran.
   [Ardekani, Abnoos Mokhtari] Kerman Univ Med Sci, Physiol Res Ctr, Kerman, Iran.
   [Vahdat, Sahar] Isfahan Univ Med Sci, Khorshid Hosp, Isfahan Kidney Dis Res Ctr, Sch Med, Esfahan, Iran.
   [Hojati, Ali] Tabriz Univ Med Sci, Fac Nutr, Dept Community Nutr, Tabriz, Iran.
   [Moradi, Hadi] Belarusian State Med Univ BSMU, Fac Med, Minsk, BELARUS.
   [Tousi, Ayda Zahiri] Imam Reza Int Univ, Razavi Hosp, Razavi Canc Res Ctr, Mashhad, Iran.
   [Ebrahimzadeh, Farnoosh] Mashhad Univ Med Sci, Fac Med, Dept Internal Med, Mashhad, Iran.
   [Farhangi, Mahdieh Abbasalizad] Tabriz Univ Med Sci, Tabriz Hlth Serv Management Res Ctr, Attar Neyshabouri St,Daneshgah Blvd, Tabriz, Iran.
C3 Kerman University of Medical Sciences; Kerman University of Medical
   Sciences; Isfahan University of Medical Sciences; Tabriz University of
   Medical Science; Belarusian State Medical University; Mashhad University
   of Medical Sciences; Tabriz University of Medical Science
RP Ebrahimzadeh, F (corresponding author), Mashhad Univ Med Sci, Fac Med, Dept Internal Med, Mashhad, Iran.; Farhangi, MA (corresponding author), Tabriz Univ Med Sci, Tabriz Hlth Serv Management Res Ctr, Attar Neyshabouri St,Daneshgah Blvd, Tabriz, Iran.
EM ebrahimzadehf@mums.ac.ir; abbasalizad_m@yahoo.com
RI vahdat, sahar/C-6492-2018; Mokhtari, Abnoos/GYV-5829-2022; Farhangi,
   Mahdieh/AAC-6758-2019
FU Research Undersecretary of Tabriz University of Medical Sciences [70388]
FX AcknowledgementsThe authors wish to thank all the study participants for
   the sincere collaboration. We also thank from Research Undersecretary of
   Tabriz University of Medical Sciences for their financial support (Grant
   number: 70388)
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NR 97
TC 19
Z9 19
U1 1
U2 11
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1472-6823
J9 BMC ENDOCR DISORD
JI BMC Endocr. Disord.
PD FEB 2
PY 2023
VL 23
IS 1
AR 29
DI 10.1186/s12902-023-01284-8
PG 12
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 8I5IM
UT WOS:000921767300001
PM 36726099
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Prajwal, V
   Arun, V
   Ramya, MC
   Nagaraj, S
   Krishnaveni, GV
   Kumaran, K
   Fall, CHD
   Krishna, M
AF Prajwal, V
   Arun, Vanishri
   Ramya, M. C.
   Nagaraj, Santhosh
   Krishnaveni, Ghattu V.
   Kumaran, Kalyanaraman
   Fall, Caroline H. D.
   Krishna, Murali
TI Validation of EURO-D, a geriatric depression scale in South India:
   Findings from the Mysore study of Natal effects on Ageing and Health
   (MYNAH)
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Article
DE Validation; EURO-D; Geriatric depression; India
ID LATE-LIFE; MENTAL STATE; METABOLIC SYNDROME; SYMPTOMS; PREVALENCE;
   DIAGNOSIS; DEMENTIA; RISK; COMMUNITY; INEQUALITIES
AB Introduction: Many of the assessment tools used to study depression amongst older people in low- and middle-income countries (LMICs) are adaptations of instruments developed in other cultural settings. There is a need to validate those instruments in LMICs.
   Methods: 721 men and women aged 55-80 years from the Mysore Birth Records Cohort underwent standardised assessments for sociodemographic characteristics, cardiometabolic risk factors, cognitive function and mental health. Sensitivity, specificity and level of agreement of EURO-D diagnosis of depression with diagnosis of depression derived by the Geriatric Mental State (GMS) examination were calculated. To validate the EURO-D score against GMS depressive episode, we used maximum Youden's index as the criterion for each cut-off point. Concurrent validity was assessed by measuring correlations with the WHO Disability Assessment Schedule (WHO DAS II).
   Results: Of the 721 (408 men and 313 women) who participated in this study, 138 (54 men and 84 women) were diagnosed with depression. Women had higher depression scores on the EURO-D scale and disability on the WHO DAS II scale. A maximum Youden's Index of 0.60 was observed at a EURO-D cut-off of 6, which corresponded to 95% sensitivity, 64% specificity, kappa value of 0.6 and area under the curve (AUC) of 80%. There was significant and positive correlation between EURO-D and WHO DAS II scores.
   Limitations: Future independent validation studies in other settings are required.
   Discussion: This study supports the use of the EURO-D scale for diagnosing depression amongst older adults in South India.
C1 [Prajwal, V; Arun, Vanishri] SJCE JSS Sci & Technol Univ, Mysore, Karnataka, India.
   [Ramya, M. C.; Nagaraj, Santhosh; Krishnaveni, Ghattu V.; Kumaran, Kalyanaraman; Krishna, Murali] CSI Holdsworth Mem Hosp, Mysore, Karnataka, India.
   [Kumaran, Kalyanaraman; Fall, Caroline H. D.] Univ Southampton, MRC Lifecourse Epidemiol Unit, Southampton, Hants, England.
   [Krishna, Murali] Fdn Res & Advocacy Mental Hlth, Mysore, Karnataka, India.
C3 Sri Jayachamarajendra College of Engineering; University of Southampton
RP Krishna, M (corresponding author), CSI Holdsworth Mem Hosp, Mysore, Karnataka, India.; Krishna, M (corresponding author), Fdn Res & Advocacy Mental Hlth, Mysore, Karnataka, India.
EM muralidoc@gmail.com
RI Kumaran, Kalyanaraman/KCK-5741-2024; Krishna, Murali/HMD-3872-2023;
   Arun, Vanishri/GPX-1687-2022
FU Welcome DBT India Alliance; MRC [MC_UP_A620_1016, MC_UU_12011/3] Funding
   Source: UKRI
FX This study was supported by an Early Career Fellowship grant awarded to
   Dr Murali Krishna by Welcome DBT India Alliance.
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NR 54
TC 9
Z9 9
U1 1
U2 4
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD DEC 1
PY 2021
VL 295
BP 939
EP 945
DI 10.1016/j.jad.2021.08.045
EA SEP 2021
PG 7
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA YE7XZ
UT WOS:000741335300012
PM 34706466
OA hybrid, Green Accepted
DA 2025-06-11
ER

PT J
AU Stanton, R
   Platania-Phung, C
   Gaskin, CJ
   Happell, B
AF Stanton, Robert
   Platania-Phung, Chris
   Gaskin, Cadeyrn J.
   Happell, Brenda
TI Screening for Metabolic Syndrome in Mental Health Consumers Using an
   Electronic Metabolic Monitoring Form
SO ISSUES IN MENTAL HEALTH NURSING
LA English
DT Article
ID PREVALENCE; SCHIZOPHRENIA; RISK; ABNORMALITIES; INTERVENTION;
   METAANALYSIS; ILLNESS; OBESITY; PEOPLE; POWER
AB Metabolic syndrome is more prevalent in people with serious mental illness, compared to the general population. The main purpose of this study was to determine the extent electronic metabolic monitoring forms were being completed in a regional mental health service and the extent to which diagnoses of metabolic syndrome could be made using the data available. A retrospective file audit of 721 electronic mental health consumer records was undertaken. Metabolic monitoring data were recorded for 261 (36%) consumers, of which 57 (21.8%) met the clinical criteria for metabolic syndrome, 61 (23.4%) did not meet clinical criteria, and diagnoses could not be made for 143 (54.8%) consumers due to missing data. The limited use of electronic health records may inhibit the detection of risk factors for the diagnosis of metabolic syndrome.
C1 [Stanton, Robert; Gaskin, Cadeyrn J.] Cent Queensland Univ, Sch Med & Appl Sci, Rockhampton, Qld 4702, Australia.
   [Platania-Phung, Chris; Happell, Brenda] Univ Canberra, SYNERGY Nursing & Midwifery Res Ctr, Fac Hlth, Canberra, ACT 2601, Australia.
   [Platania-Phung, Chris; Happell, Brenda] ACT Hlth, Canberra, ACT, Australia.
   [Gaskin, Cadeyrn J.] Gaskin Res, Melbourne, Vic, Australia.
C3 Central Queensland University; University of Canberra; ACT Health
   Australia
RP Stanton, R (corresponding author), CQUniversity, Sch Med & Appl Sci, Bruce Highway, North Rockhampton, Qld 4702, Australia.
EM r.stanton@cqu.edu.au
RI Stanton, Rob/AAJ-5157-2020; Happell, Brenda/HSI-0570-2023
OI Happell, Brenda/0000-0002-7293-6583; Gaskin, Cadeyrn/0000-0001-5240-4320
FU Queensland Centre for Social Science Innovation
FX The authors acknowledge the funding provided by the (former) Queensland
   Centre for Social Science Innovation.
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NR 42
TC 7
Z9 9
U1 0
U2 3
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 0161-2840
EI 1096-4673
J9 ISSUES MENT HEALTH N
JI Issues Ment. Health Nurs.
PY 2016
VL 37
IS 4
BP 239
EP 244
DI 10.3109/01612840.2015.1119221
PG 6
WC Nursing; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Nursing; Psychiatry
GA DO6DE
UT WOS:000377872600005
PM 26963890
DA 2025-06-11
ER

PT J
AU Guedes, EP
   Madeira, E
   Mafort, TT
   Madeira, M
   Moreira, RO
   Mendonça, LMC
   Godoy-Matos, AF
   Lopes, AJ
   Farias, MLF
AF Guedes, Erika P.
   Madeira, Eduardo
   Mafort, Thiago T.
   Madeira, Miguel
   Moreira, Rodrigo O.
   Mendonca, Laura M. C.
   Godoy-Matos, Amelio F.
   Lopes, Agnaldo J.
   Farias, Maria Lucia F.
TI Body composition and depressive/anxiety symptoms in overweight and obese
   individuals with metabolic syndrome
SO DIABETOLOGY & METABOLIC SYNDROME
LA English
DT Article
DE Anxiety; Body composition; Depression; Dual energy X-ray Absorptiometry;
   Metabolic syndrome; Obesity
ID ABDOMINAL OBESITY; FAT DISTRIBUTION; DEPRESSION; ASSOCIATION; DISORDERS;
   ADIPOSITY; THERAPY; ILLNESS; ADULTS; RISK
AB Background: Several studies point to a correlation between obesity and the severity of depressive and anxiety symptoms in children and adults, but there are still some controversial points about this association. The aim of this study is to investigate the relationship between body composition and the severity of anxiety/depressive symptoms in overweight and obese individuals with Metabolic Syndrome (MS).
   Methods: Fifty patients, 18-50 years old, overweight or obese and with the diagnosis of MS based on the International Diabetes Federation (IDF) criteria were selected for this study. Body composition was evaluated using Dual Energy X-ray Absorptiometry (DXA). Depressive symptoms were evaluated using the Hospital Anxiety and Depression Scale (HADS-Depression) and the Beck Depression Inventory (BDI). Anxiety symptoms were evaluated using HADS-Anxiety.
   Results: No correlation was found between depressive symptoms (HADS-Depression or BDI) and Body Mass Index (BMI) (r = 0.01; p = 0.94 and r = -0.12, p = 0.38; respectively), Waist Circumference (WC) (r = -0.06, p = 0.67 and r = -0.22, p = 0.12; respectively), and Waist-to-Hip Ratio (WHR) (r = -0.12, p = 0.40 and r = -0.17, p = 0.23; respectively). Additionally, no correlation was found among anxiety symptoms (HADS-Anxiety) and BMI (r = -0.15, p = 0.27), and WHR (r = -0.17, p = 0.24). In contrast, a significant correlation was found between percentage of total fat (DXA) and HADS-Depression (r = 0.34, p = 0.019) and HADS-Anxiety (r = 0.30, p = 0.039). Additionally, an inverse and strong correlation was found between lean mass (in grams) and HADS-Depression (r = -0.42, p = 0.004), HADS anxiety (r = -0.57, p < 0.0001), and BDI (r = -0.44, p = 0.026).
   Conclusions: In individuals with MS, the percentage of body fat, and not central fat, BMI, WC, or WHR, was associated with an increased severity of anxiety and depressive symptoms. In contrast, total lean mass was strongly associated with fewer anxiety/depressive symptoms, suggesting that body composition might be related to psychiatric comorbidity in overweight individuals with MS.
C1 [Guedes, Erika P.; Moreira, Rodrigo O.; Godoy-Matos, Amelio F.] State Inst Diabet & Endocrinol Rio De Janeiro, Div Metab, BR-20211340 Rio De Janeiro, Brazil.
   [Madeira, Eduardo] Univ Estado Rio De Janeiro, Div Gastroenterol, Rio De Janeiro, Brazil.
   [Mafort, Thiago T.; Lopes, Agnaldo J.] Univ Estado Rio De Janeiro, Div Pneumol, Rio De Janeiro, Brazil.
   [Madeira, Miguel; Farias, Maria Lucia F.] Univ Fed Rio de Janeiro, Div Endocrinol, Rio De Janeiro, Brazil.
   [Mendonca, Laura M. C.] Univ Fed Rio de Janeiro, Div Rheumatol, Rio De Janeiro, Brazil.
C3 Universidade do Estado do Rio de Janeiro; Universidade do Estado do Rio
   de Janeiro; Universidade Federal do Rio de Janeiro; Universidade Federal
   do Rio de Janeiro
RP Guedes, EP (corresponding author), State Inst Diabet & Endocrinol Rio De Janeiro, Div Metab, Rua Moncorvo Filho 90 Ctr, BR-20211340 Rio De Janeiro, Brazil.
EM erikapaniago@uol.com.br
RI Lopes, Agnaldo/B-6430-2016; Moreira, Rodrigo/N-7131-2015; Lopes, Agnaldo
   Jose/AAB-5944-2019
OI Guedes, ERIKA/0000-0003-4430-8069; Lopes, Agnaldo
   Jose/0000-0001-8598-4878; Godoy-Matos, Amelio/0000-0001-9089-9889
CR [Anonymous], 2006, The IDF Consensus Worldwide Definition of the Metabolic Syndrome
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NR 26
TC 31
Z9 32
U1 0
U2 16
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1758-5996
J9 DIABETOL METAB SYNDR
JI Diabetol. Metab. Syndr.
PD DEC 23
PY 2013
VL 5
AR 82
DI 10.1186/1758-5996-5-82
PG 5
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA AB9ED
UT WOS:000332092200001
PM 24364839
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Jaremka, LM
   Lindgren, ME
   Kiecolt-Glaser, JK
AF Jaremka, Lisa M.
   Lindgren, Monica E.
   Kiecolt-Glaser, Janice K.
TI SYNERGISTIC RELATIONSHIPS AMONG STRESS, DEPRESSION, AND TROUBLED
   RELATIONSHIPS: INSIGHTS FROM PSYCHONEUROIMMUNOLOGY
SO DEPRESSION AND ANXIETY
LA English
DT Review
DE biological markers; depression; cognition; life events; stress;
   interpersonal relationships; psychoneuroimmunology; antidepressants
ID C-REACTIVE PROTEIN; CORONARY-HEART-DISEASE; RANDOMIZED CONTROLLED-TRIAL;
   GINGIVAL CREVICULAR FLUID; ACUTE MENTAL STRESS; SUPPLEMENTATION LOWERS
   INFLAMMATION; SOCIOECONOMIC-STATUS; PSYCHOLOGICAL STRESS; OLDER-ADULTS;
   CARDIOVASCULAR-DISEASE
AB Stress and depression consistently elevate inflammation and are often experienced simultaneously, which is exemplified by people in troubled relationships. Troubled relationships also elevate inflammation, which may be partially explained by their ability to engender high levels of stress and depression. People who are stressed, depressed, or in troubled relationships are also at greater risk for health problems than their less distressed counterparts. Inflammation, a risk factor for a variety of age-related diseases including cardiovascular disease, Type II diabetes, metabolic syndrome, and frailty, may be one key mechanistic pathway linking distress to poor health. Obesity may further broaden the health implications of stress and depression; people who are stressed or depressed are often overweight, and adipose tissue is a major source of proinflammatory cytokines. Stress, depression, and troubled relationships may have synergistic inflammatory effects: loneliness, subclinical depression, and major depression enhance inflammatory responses to an acute stressful event. The relationship between distress and inflammation is bidirectional; depression enhances inflammation and inflammation promotes depression. Interesting questions emerge from this literature. For instance, some stressors may be more potent than others and thus may be more strongly linked to inflammation. In addition, it is possible that psychological and interpersonal resources may buffer the negative inflammatory effects of stress. Understanding the links among stress, depression, troubled relationships, and inflammation is an exciting area of research that may provide mechanistic insight into the links between distress and poor health.
C1 [Jaremka, Lisa M.; Lindgren, Monica E.; Kiecolt-Glaser, Janice K.] Ohio State Univ, Inst Behav Med Res, Coll Med, Columbus, OH 43210 USA.
   [Kiecolt-Glaser, Janice K.] Ohio State Univ, Coll Med, Dept Psychiat, Columbus, OH 43210 USA.
C3 University System of Ohio; Ohio State University; University System of
   Ohio; Ohio State University
RP Jaremka, LM (corresponding author), Ohio State Univ, Inst Behav Med Res, Coll Med, 460 Med Ctr Dr, Columbus, OH 43210 USA.
EM lisa.jaremka@osumc.edu
RI Kiecolt-Glaser, Janice/A-3236-2009
FU American Cancer Society Postdoctoral Fellowship
   [121911-PF-12-040-01-CPPB]; Ohio State University Comprehensive Cancer
   Center Pelotonia Postdoctoral Fellowship; National Cancer Institute
   Research Supplement to Promote Diversity in Health-Related Research
   [CA126857]; NIH [CA126857, CA131029, CA154054, AG029562]
FX Contract grant sponsor: American Cancer Society Postdoctoral Fellowship;
   Contract grant number: 121911-PF-12-040-01-CPPB; Contract grant sponsor:
   Ohio State University Comprehensive Cancer Center Pelotonia Postdoctoral
   Fellowship; Contract grant sponsor: National Cancer Institute Research
   Supplement to Promote Diversity in Health-Related Research; Contract
   grant number: CA126857; Contract grant sponsor: NIH; Contract grant
   numbers: CA131029, CA126857, CA154054, and AG029562.
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NR 146
TC 94
Z9 112
U1 2
U2 97
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1091-4269
EI 1520-6394
J9 DEPRESS ANXIETY
JI Depress. Anxiety
PD APR
PY 2013
VL 30
IS 4
BP 288
EP 296
DI 10.1002/da.22078
PG 9
WC Psychology, Clinical; Psychiatry; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA 126GJ
UT WOS:000317600800002
PM 23412999
OA Green Accepted, gold
DA 2025-06-11
ER

PT J
AU Pérez, CM
   Kiefe, C
   Person, SD
   Tucker, KL
   Torres, P
   Sandoval, E
   Boneu, C
   Ramírez, Z
   Mattei, J
   Rodríguez-Orengo, J
   Almodóvar-Rivera, I
   Rosal, MC
AF Perez, Cynthia M.
   Kiefe, Catarina, I
   Person, Sharina D.
   Tucker, Katherine L.
   Torres, Polaris
   Sandoval, Estefania
   Boneu, Claudia
   Ramirez, Zuleika
   Mattei, Josiemer
   Rodriguez-Orengo, Jose
   Almodovar-Rivera, Israel
   Rosal, Milagros C.
TI The Puerto Rico Young Adults' Stress, Contextual, Behavioral, and
   Cardiometabolic Risk (PR-OUTLOOK) Study: design and methods
SO AMERICAN JOURNAL OF EPIDEMIOLOGY
LA English
DT Article
DE cardiovascular health; risk factors; prospective cohort study; young
   adults; Hispanics/Latinos; Puerto Ricans; stress; resiliency
ID HISPANIC COMMUNITY-HEALTH; ACUTE MYOCARDIAL-INFARCTION; INTIMA-MEDIA
   THICKNESS; LIFE-STYLE FACTORS; CARDIOVASCULAR RISK; PHYSICAL-ACTIVITY;
   TRANSLATIONAL RESEARCH; METABOLIC SYNDROME; SOCIAL SUPPORT; TRAIT
   ANXIETY
AB The Puerto Rico (PR) Young Adults' Stress, Contextual, Behavioral and Cardiometabolic Risk Study (PR-OUTLOOK) is investigating overall and component-specific cardiovascular health (CVH) and cardiovascular disease (CVD) risk factors in a sample of young Puerto Rican adults (aged 18-29 years) in PR (target n = 3000) and examining relationships between individual-, family- or social-, and neighborhood-level stress and resilience factors and CVH and CVD risk factors. The study researchers are conducting standardized measurements of CVH and CVD risk factors and demographic, behavioral, psychosocial, neighborhood, and contextual variables and establishing a biorepository of blood, saliva, urine, stool, and hair samples. The assessment methods are aligned with other National Heart, Lung, and Blood Institute-funded studies: the Puerto Rico Observational Study of Psychosocial, Environmental, and Chronic Disease Trends of adults aged 30-75 years; the Hispanic Community Health Study/Study of Latinos; the Boston Puerto Rican Health Study; and the Coronary Artery Risk Development in Young Adults. PR-OUTLOOK data and the study biorepository will facilitate future longitudinal studies of the temporality of associations between stress and resilient factors and CVH and CVD risk factors among young Puerto Ricans. These resources have potential for advancing the scientific understanding of these conditions in a high-risk but understudied young population.
C1 [Perez, Cynthia M.; Torres, Polaris; Sandoval, Estefania; Boneu, Claudia; Ramirez, Zuleika] Univ Puerto Rico, Grad Sch Publ Hlth, Dept Biostat & Epidemiol, Med Sci Campus, San Juan, PR 00935 USA.
   [Kiefe, Catarina, I; Person, Sharina D.; Rosal, Milagros C.] Univ Massachusetts, Dept Populat & Quantitat Hlth Sci, Chan Med Sch, Worcester, MA USA.
   [Tucker, Katherine L.] Univ Massachusetts Lowell, Zuckerberg Coll Hlth Sci, Dept Biomed & Nutr Sci, Lowell, MA USA.
   [Tucker, Katherine L.] Univ Massachusetts Lowell, Ctr Populat Hlth, Lowell, MA USA.
   [Mattei, Josiemer] Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA.
   [Rodriguez-Orengo, Jose] Fdn Invest Clin Res, Dept Epidemiol & Biostat, San Juan, PR USA.
   [Rodriguez-Orengo, Jose] Univ Puerto Rico, Dept Biochem, Sch Med, Med Sci Campus, San Juan, PR USA.
   [Almodovar-Rivera, Israel] Univ Puerto Rico Mayaguez Campus, Coll Arts & Sci, Dept Math Sci, Mayaguez, PR USA.
C3 University of Puerto Rico; University of Puerto Rico Medical Sciences
   Campus; University of Massachusetts System; UMass Chan Medical School;
   University of Massachusetts Worcester; University of Massachusetts
   System; University of Massachusetts Lowell; University of Massachusetts
   System; University of Massachusetts Lowell; Harvard University; Harvard
   T.H. Chan School of Public Health; University of Puerto Rico; University
   of Puerto Rico Medical Sciences Campus; University of Puerto Rico;
   University of Puerto Rico Mayaguez
RP Pérez, CM (corresponding author), Univ Puerto Rico, Grad Sch Publ Hlth, Dept Biostat & Epidemiol, Med Sci Campus, San Juan, PR 00935 USA.
EM cynthia.perez1@upr.edu; sharina.person@umassmed.edu;
   polaris.torres@upr.edu; estefania.sandoval@upr.edu;
   claudia.boneu@upr.edu; zuleika.ramirez@upr.edu;
   jmattei@hsph.harvard.edu; Milagros.Rosal@umassmed.edu
RI Tucker, Katherine/A-4545-2010; Mattei, Josiemer/H-1800-2016
OI Tucker, Katherine/0000-0001-7640-662X; Person,
   Sharina/0000-0001-9121-9566; Perez, Cynthia M./0000-0003-2529-7042;
   Mattei, Josiemer/0000-0001-5424-8245
FU National Heart, Lung, and Blood Institute [R01HL149119]
FX This work was supported by the National Heart, Lung, and Blood Institute
   (grant R01HL149119 to M.C.R. and C.M.P.).
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NR 109
TC 1
Z9 1
U1 0
U2 0
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0002-9262
EI 1476-6256
J9 AM J EPIDEMIOL
JI Am. J. Epidemiol.
PD NOV 9
PY 2024
VL 194
IS 3
BP 587
EP 597
DI 10.1093/aje/kwae163
EA NOV 2024
PG 11
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Public, Environmental & Occupational Health
GA Z1H7M
UT WOS:001363081400001
PM 38932562
DA 2025-06-11
ER

PT J
AU Tham, M
   Terence, WH
   Jenkins, ZM
   Castle, DJ
AF Tham, Marlene
   Terence, W. H.
   Jenkins, Zoe M.
   Castle, David J.
TI The use of anti-obesity medications in people with mental illness as an
   adjunct to lifestyle interventions - Effectiveness, tolerability and
   impact on eating behaviours: A 52-week observational study
SO OBESITY RESEARCH & CLINICAL PRACTICE
LA English
DT Article
DE Anti-obesity medications; Mental health; Metabolic syndrome;
   Psychotropic weight gain; Obesity
AB Objective: The increasing prevalence of obesity and metabolic syndrome in people with mental illness (MI) is a global health priority. Anti-obesity medications (AOMs) may help with reducing medication induced hunger and weight gain when lifestyle changes are insufficient. Our aim is to evaluate the effectiveness, tolerability, impact on eating behaviours and psychiatric safety of AOMs in this population.
   Methods: We conducted an observational study of 244 adults with MI with at least two risk factors for metabolic syndrome attending an obesity management clinic. Participants received standardised diet, exercise and psychological care, in addition to AOMs tailored to each participant's circumstances. Baseline and 12-month assessments encompassing physical, metabolic and psychological parameters were compared.
   Results: Over the course of the study, the average weight loss was 11.79 kg (12.1%), decrease in BMI was 3.90 kg/m(2) and reduction in waist circumference was 12.6 cm. Participants with good glycaemic control increased from 28.6% to 80.7%, hypercholesterolaemia reduced from 85.2%-29.9% and hypertension rates reduced from 88.9%-52.0%. Depression, anxiety and stress levels for the sample decreased significantly (all p < .01). Eating behaviours improved (all p < .001) at follow-up. Psychiatric side effects including deterioration of mood (28.2%) and suicidality (30.8%) were primarily experienced by those on topiramate.
   Conclusions: AOMs can be effective in achieving clinically meaningful weight loss, improved metabolic co-morbidities and eating behaviours in people living with MI, when combined with a comprehensive lifestyle program. The majority of AOMs are well tolerated but topiramate appears more likely to negatively impact mental health. (C) 2020 Asia Oceania Association for the Study of Obesity. Published by Elsevier Ltd. All rights reserved.
C1 [Tham, Marlene; Terence, W. H.] Epworth Healthcare, Med & Mind Weight Loss, Ground Floor,888 Toorak Rd, Camberwell, Vic, Australia.
   [Tham, Marlene; Terence, W. H.; Jenkins, Zoe M.; Castle, David J.] St Vincents Hosp, Dept Psychiat, Melbourne, Vic, Australia.
   [Tham, Marlene; Terence, W. H.; Jenkins, Zoe M.; Castle, David J.] Univ Melbourne, Dept Psychiat, Melbourne, Vic, Australia.
   [Tham, Marlene; Terence, W. H.] Epworth Clin Camberwell, Epworth Healthcare, Suite 5,Level 3,888 Toorak Rd, Camberwell, Vic 3124, Australia.
C3 St Vincent's Health; St Vincent's Hospital Melbourne; NSW Health; St
   Vincents Hospital Sydney; University of Melbourne
RP Tham, M (corresponding author), Ground Floor,888 Toorak Rd, Camberwell, Vic, Australia.
EM mschong@tpg.com.au
OI Jenkins, Zoe/0000-0002-8551-0792; Castle, David/0000-0002-3075-1580;
   Chong, Terence/0000-0003-2432-8193
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NR 35
TC 8
Z9 8
U1 0
U2 4
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 1871-403X
EI 1878-0318
J9 OBES RES CLIN PRACT
JI Obes. Res. Clin. Pract.
PD JAN-FEB
PY 2021
VL 15
IS 1
BP 49
EP 57
DI 10.1016/j.orcp.2020.11.002
EA FEB 2021
PG 9
WC Endocrinology & Metabolism; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Nutrition & Dietetics
GA RB1JY
UT WOS:000631873900008
PM 33257207
DA 2025-06-11
ER

PT J
AU Santos, ARC
   Abreu, ARR
   Noronha, SISR
   Reis, TO
   Santos, DM
   Chianca-JR, DA
   da Silva, LG
   de Menezes, RCA
   Velloso-Rodrigues, C
AF Santos, Aquila Rodrigues Costa
   Abreu, Aline Rezende R.
   Noronha, Sylvana I. S. R.
   Reis, Thayane Oliveira
   Santos, Daisy Motta
   Chianca-JR, Deoclecio Alves
   da Silva, Luiz Gonzaga
   de Menezes, Rodrigo Cunha Alvim
   Velloso-Rodrigues, Cibele
TI Thermoregulatory responses, heart rate, and the susceptibility to
   anxiety in obese animals subjected to stress
SO PHYSIOLOGY & BEHAVIOR
LA English
DT Article
DE Obesity; Stress; Thermoregulatory responses; Heart rate; Anxiety -like
   behavior; Behavior
ID ADIPOSE-TISSUE THERMOGENESIS; SYMPATHETIC-NERVE ACTIVITY; FAT DIET
   ALTERS; DORSOMEDIAL HYPOTHALAMUS; PSYCHOLOGICAL STRESS; METABOLIC
   SYNDROME; VISCERAL FAT; RISK-FACTOR; BEHAVIOR; INFLAMMATION
AB Obesity and stress are related to cardiovascular diseases. Rats fed a high-fat diet (HFD) show increased cardiovascular reactivity to emotional stress and altered defensive behavioral responses. Indeed, changes in thermoregulatory responses in an aversive environment are observed in these animals. However, studies aimed at clarifying the physiological mechanisms linking obesity, stress hyperreactivity and behavioral changes are needed. The aim of this study was to evaluate the changes in thermoregulatory responses, heart rate, and the susceptibility to anxiety in obese animals subjected to stress. Nine-week high-fat diet protocol was effective in inducing obesity by increasing weight gain, fat mass, adiposity index, white epididymal, retroperitoneal, inguinal and brown adipose tissue. Animals induced to obesity and subjected to stress (HFDS group) by the intruder animal method showed increases in heart rate (HR), core body temperature and tail temperature. HFDS showed an increase in the first exposure to the closed arm (anxiety-like behavior) in elevated T-Maze (ETM). The groups did not differ with respect to panic behavior assessed in the ETM and locomotor activity in the open field test. Our study shows that HFDS animals presented increased reactivity to stress with higher stress hyperthermia and anxious behavior. Thus, our results present relevant information regarding stress responsiveness and behavioral changes in obese animals.
C1 [Santos, Aquila Rodrigues Costa] Fundacao Oswaldo Cruz, Oswaldo Cruz Inst, Lab Thymus Res, Rio De Janeiro, Brazil.
   [Santos, Aquila Rodrigues Costa; da Silva, Luiz Gonzaga; Velloso-Rodrigues, Cibele] Univ Fed Juiz de Fora, Dept Basic Life Sci, Governador Valadares, Brazil.
   [Abreu, Aline Rezende R.; Noronha, Sylvana I. S. R.; Reis, Thayane Oliveira; Chianca-JR, Deoclecio Alves; de Menezes, Rodrigo Cunha Alvim] Univ Fed Ouro Preto, Dept Biol Sci, Lab Cardiovasc Physiol, Ouro Preto, Brazil.
   [Santos, Daisy Motta] Univ Fed Minas Gerais, Sch Phys Educ Physiotherapy & Occupat Therapy, Dept Sports, Belo Horizonte, Brazil.
   [Velloso-Rodrigues, Cibele] Univ Fed Juiz de Fora, Dept Basic Life Sci, Lab Cell Biol & Mol Genet, BR-35032200 Governador Valadares, MG, Brazil.
C3 Fundacao Oswaldo Cruz; Universidade Federal de Juiz de Fora;
   Universidade Federal de Ouro Preto; Universidade Federal de Minas
   Gerais; Universidade Federal de Juiz de Fora
RP Velloso-Rodrigues, C (corresponding author), Univ Fed Juiz de Fora, Dept Basic Life Sci, Lab Cell Biol & Mol Genet, BR-35032200 Governador Valadares, MG, Brazil.
EM cibele.velloso@ufjf.br
RI Menezes, Rodrigo/I-5149-2012; S. R. Noronha, Sylvana Izaura/P-5812-2018;
   Velloso-Rodrigues, Cibele/Q-4632-2017; da Silva, Luíz
   Guilherme/ABU-3762-2022; Alves Chianca Junior, Deoclecio/JJC-7747-2023;
   Rezende Ribeiro de Abreu, Aline/ABB-7570-2021
OI Rezende Ribeiro de Abreu, Aline/0000-0002-4093-2174; Velloso-Rodrigues,
   Cibele Velloso Rodrigues/0000-0002-4998-1765
FU Cell biology and Molecular Genetics Laboratory/UFJF-GV
FX The authors thank all the members of Cell biology and Molecular Genetics
   Laboratory/UFJF-GV, to all Laboratory of Hypertension/UFMG members, all
   the members of Cardiovascular Physiology Labo-ratory, to Marly Lessa and
   Milton de Paula for their technical assistance and the Center of Animal
   Science (CCA) for providing rats.
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NR 59
TC 1
Z9 1
U1 1
U2 6
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0031-9384
EI 1873-507X
J9 PHYSIOL BEHAV
JI Physiol. Behav.
PD JUL 1
PY 2023
VL 266
AR 114181
DI 10.1016/j.physbeh.2023.114181
EA APR 2023
PG 9
WC Psychology, Biological; Behavioral Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Behavioral Sciences
GA E5EQ2
UT WOS:000975774000001
PM 37019294
DA 2025-06-11
ER

PT J
AU Younge, JO
   Leening, MJG
   Tiemeier, H
   Franco, OH
   Kiefte-de Jong, J
   Hofman, A
   Roos-Hesselink, JW
   Hunink, MGM
AF Younge, John O.
   Leening, Maarten J. G.
   Tiemeier, Henning
   Franco, Oscar H.
   Kiefte-de Jong, Jessica
   Hofman, Albert
   Roos-Hesselink, Jolien W.
   Hunink, M. G. Myriam
TI Association Between Mind-Body Practice and Cardiometabolic Risk Factors:
   The Rotterdam Study
SO PSYCHOSOMATIC MEDICINE
LA English
DT Article
ID CARDIOVASCULAR-DISEASE; COMPLEMENTARY THERAPIES; MYOCARDIAL-INFARCTION;
   RELAXATION RESPONSE; STRESS REDUCTION; HEART-DISEASE; 52 COUNTRIES;
   QUESTIONNAIRE; MANAGEMENT; HEALTH
AB Objectives
   The increased popularity of mind-body practices highlights the need to explore their potential effects. We determined the cross-sectional association between mind-body practices and cardiometabolic risk factors.
   Methods
   We used data from 2579 participants free of cardiovascular disease from the Rotterdam Study (2009-2013). A structured home-based interview was used to evaluate engagement in mind-body practices including meditation, yoga, self-prayer, breathing exercises, or other forms of mind-body practice. We regressed engagement in mind-body practices on cardiometabolic risk factors (body mass index, blood pressure, and fasting blood levels of cholesterol, triglycerides, and glucose) and presence of metabolic syndrome. All analyses were adjusted for age, sex, educational level, smoking, alcohol consumption, (in)activities in daily living, grief, and depressive symptoms.
   Results
   Fifteen percent of the participants engaged in a form of mind-body practice. Those who did mind-body practices had significantly lower body mass index (beta = -0.84 kg/m(2), 95% confidence interval [CI] = -1.30 to -0.38, p < .001), log-transformed triglyceride levels (beta = -0.02, 95% CI = -0.04 to -0.001, p = .037), and log-transformed fasting glucose levels (beta = -0.01, 95% CI = -0.02 to -0.004, p = .004). Metabolic syndrome was less common among individuals who engaged in mind-body practices (odds ratio = 0.71, 95% CI = 0.54-0.95, p = .019).
   Conclusions
   Individuals who do mind-body practices have a favorable cardiometabolic risk profile compared with those who do not. However, the cross-sectional design of this study does not allow for causal inference and prospective, and intervention studies are needed to elucidate the association between mind-body practices and cardiometabolic processes.
C1 [Younge, John O.; Leening, Maarten J. G.; Roos-Hesselink, Jolien W.] Erasmus MC, Dept Cardiol, Rotterdam, Netherlands.
   [Younge, John O.; Leening, Maarten J. G.; Tiemeier, Henning; Franco, Oscar H.; Kiefte-de Jong, Jessica; Hofman, Albert; Hunink, M. G. Myriam] Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands.
   [Tiemeier, Henning] Erasmus MC, Dept Psychiat, Rotterdam, Netherlands.
   [Hunink, M. G. Myriam] Erasmus MC, Dept Radiol, Rotterdam, Netherlands.
   [Hunink, M. G. Myriam] Harvard Univ, TH Chan Sch Publ Hlth, Dept Hlth Policy & Management, Boston, MA 02115 USA.
C3 Erasmus University Rotterdam; Erasmus MC; Erasmus University Rotterdam;
   Erasmus MC; Erasmus University Rotterdam; Erasmus MC; Erasmus University
   Rotterdam; Erasmus MC; Harvard University; Harvard T.H. Chan School of
   Public Health
RP Hunink, MGM (corresponding author), Dept Epidemiol, Wytemanweg 80,Off NA-2818, NL-3015 CN Rotterdam, Netherlands.
EM m.hunink@erasmusmc.nl
RI Franco, Óscar/ABE-2305-2020; Kiefte-de Jong, Jessica/GLV-3216-2022;
   Tiemeier, Henning/H-6534-2019
OI Leening, Maarten J. G./0000-0002-4143-4839; Hunink,
   Myriam/0000-0002-2942-2798; Kiefte-de Jong, Jessica/0000-0002-8136-0918;
   Franco, Oscar/0000-0002-4606-4929
FU Erasmus MC; Erasmus University Rotterdam; Netherlands Organisation for
   Scientific Research; Netherlands Organisation for Health Research and
   Development; Research Institute for Diseases in the Elderly; Netherlands
   Genomics Initiative; Ministry of Education, Culture and Science;
   Ministry of Health, Welfare and Sports; European Commission (DG XII);
   Municipality of Rotterdam
FX Younge, Roos-Hesselink, and Hunink were supported by an internal grant
   from the Erasmus MC for this study. The Rotterdam Study is supported by
   the Erasmus MC and Erasmus University Rotterdam; the Netherlands
   Organisation for Scientific Research; the Netherlands Organisation for
   Health Research and Development; the Research Institute for Diseases in
   the Elderly; the Netherlands Genomics Initiative; the Ministry of
   Education, Culture and Science, the Ministry of Health, Welfare and
   Sports; the European Commission (DG XII); and the Municipality of
   Rotterdam. None of the funders had any role in design and conduct of the
   study; collection, management, analysis, and interpretation of the data;
   and preparation, review, or approval of the manuscript.
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NR 55
TC 12
Z9 12
U1 2
U2 39
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0033-3174
EI 1534-7796
J9 PSYCHOSOM MED
JI Psychosom. Med.
PD SEP
PY 2015
VL 77
IS 7
BP 775
EP 783
DI 10.1097/PSY.0000000000000213
PG 9
WC Psychiatry; Psychology; Psychology, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry; Psychology
GA CQ9VU
UT WOS:000360964100007
PM 26186434
DA 2025-06-11
ER

PT J
AU Bjelanovic, V
   Babic, D
   Hodzic, D
   Bjelanovic, A
   Kresic, T
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   Oreskovic, S
AF Bjelanovic, Vedran
   Babic, Dragan
   Hodzic, Damir
   Bjelanovic, Ana
   Kresic, Tanja
   Dugandzic-Simic, Ana
   Oreskovic, Slavko
TI CORRELATION OF PSYCHOLOGICAL SYMPTOMS WITH CORTISOL AND CRP LEVELS IN
   PREGNANT WOMEN WITH METABOLIC SYNDROME
SO PSYCHIATRIA DANUBINA
LA English
DT Article
DE pregnancy; metabolic syndrome; cortisol, glucose; psychological symptoms
ID PREVALENCE; ANXIETY; STRESS; ASSOCIATION; DEPRESSION; DISTRESS; OBESITY;
   RISKS; SLEEP; AGE
AB Background: In pregnancy occurs series of physiological, organic and psychological changes in the female organism. Particularly are significant hormonal and metabolic changes. Elevated cortisol levels are reduced by linking the transport of globulin (transcortin). Triglycerides were increased 50% and other lipids from 20 to 30%. The values of CRP were slightly elevated in the third trimester of pregnancy (10-15 mg / L). To investigate the association of psychological symptoms with the level of cortisol and CRP in women with metabolic syndrome.
   Subjects and methods: From 1646 pregnant women cross-sectional, prospective study included 180 pregnant women divided into three groups by applying the inclusion and exclusion criteria. Research methods are laboratory and clinical tests and questionnaires. Every pregnant woman have been made complete laboratory findings and determined cortisol in 8 and 17 hours using the chemiluminescent immunoassay method. All pregnant women filled in several questionnaires: socio-demographic, obstetrical-gynecological, standardized psychometric questionnaire (SCL 90-R), a questionnaire syndrome of depression according to ICD 10 and Beck self depression scale. The study was conducted from August 2011 to mid-November 2012.
   Results: From the total of 1646 hospitalized pregnant women, 176 pregnant women had a BMI>30 and 120 of them were tested, but 60 had criteria for MS. The concentration of morning and afternoon cortisol is increased in pregnant women with the metabolic syndrome Obese pregnant women have a statistically higher level and morning and afternoon cortisol levels than women with normal body weight and without the metabolic syndrome, but these differences are smaller than in the case of pregnant women with the metabolic syndrome. CRP is significantly higher in women with metabolic syndrome. CRP concentration is significantly higher in obese pregnant women compared to pregnant women with normal weight and without the metabolic syndrome, but it is lower than in pregnant women with the metabolic syndrome. The incidence of psychological symptoms as somatization, obsessive-compulsive symptoms, depression, anxiety, phobia, and nonspecific symptoms is statistically increased in pregnant women with elevated morning cortisol, but in women with elevated afternoon cortisol also occurring aggressiveness and paranoia. In pregnant women with elevated CRP is statistically higher incidence of psychological symptoms such as somatization, obsessive-compulsive symptoms, depression, anxiety, and nonspecific symptoms.
   Conclusion: There is a statistically significantly higher levels of cortisol and C-reactive protein in obese pregnant women and pregnant women with the criteria of MS. Morning cortisol has a specific predictive value for the diagnosis of MS, but the values of CRP are changing in numerous physiological and pathological conditions and cannot be taken as a predictive factor in the diagnosis of MS. Pregnant women with MS and elevated morning and evening levels of cortisol and CRP shows a statistically significant higher number of complications in pregnancy and psychological symptoms.
C1 [Bjelanovic, Vedran; Babic, Dragan; Bjelanovic, Ana; Kresic, Tanja; Dugandzic-Simic, Ana; Oreskovic, Slavko] Univ Mostar, Sch Med, Mostar 88000, Bosnia & Herceg.
   [Babic, Dragan; Kresic, Tanja; Dugandzic-Simic, Ana] Univ Clin Hosp Mostar, Dept Psychiat, Mostar, Bosnia & Herceg.
   [Bjelanovic, Vedran] Univ Clin Hosp Mostar, Dept Gynecol & Obstet, Mostar, Bosnia & Herceg.
   [Hodzic, Damir] Univ Clin Hosp Merkur, Dept Gynecol & Obstet, Zagreb, Croatia.
   [Oreskovic, Slavko] Univ Zagreb, Sch Med, Zagreb 41000, Croatia.
C3 University of Mostar; University of Mostar; University of Mostar;
   University of Zagreb
RP Bjelanovic, V (corresponding author), Univ Mostar, Sch Med, Petra Kresimira Bb, Mostar 88000, Bosnia & Herceg.
EM vedranbjelanovic@yahoo.com
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NR 48
TC 0
Z9 0
U1 0
U2 7
PU MEDICINSKA NAKLADA
PI ZAGREB
PA VLASKA 69, HR-10000 ZAGREB, CROATIA
SN 0353-5053
J9 PSYCHIAT DANUB
JI Psychiatr. Danub.
PY 2015
VL 27
SU 2
BP 34
EP 41
PG 8
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA DP2UB
UT WOS:000378347400004
DA 2025-06-11
ER

PT J
AU Kunutsor, SK
   Jassal, DS
   Ravandi, A
   Lehoczki, A
AF Kunutsor, Setor K.
   Jassal, Davinder S.
   Ravandi, Amir
   Lehoczki, Andrea
TI Dietary flaxseed: Cardiometabolic benefits and its role in promoting
   healthy aging
SO GEROSCIENCE
LA English
DT Review; Early Access
DE Flaxseed; Cardiometabolic; Type 2 diabetes; Hypertension; Metabolic
   syndrome; Chronic kidney disease; Cardiovascular disease; Mortality
ID ALPHA-LINOLENIC-ACID; CORONARY-HEART-DISEASE; C-REACTIVE PROTEIN;
   OXIDATIVE STRESS; CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME;
   BLOOD-PRESSURE; MEDITERRANEAN DIET; RISK-FACTORS; SECOISOLARICIRESINOL
   DIGLUCOSIDE
AB Flaxseed, a rich source of omega-3 polyunsaturated fatty acid alpha-linolenic acid (ALA), lignans, and soluble fiber, has attracted attention for its potential to improve multiple cardiometabolic risk factors. While its benefits are well-recognized, comprehensive evaluations of its direct impact on clinical outcomes, such as the prevention or progression of cardiometabolic diseases, remain limited. Additionally, its potential to support healthy aging and longevity through fundamental biological mechanisms has not been fully elucidated. This review synthesizes existing research on flaxseed supplementation, highlighting its effects on cardiometabolic risk factors and outcomes, the underlying biological mechanisms, and its broader implications for health promotion and aging. Findings demonstrate that flaxseed supplementation significantly improves several cardiometabolic risk factors, including body weight, body mass index, lipid levels, blood pressure, glycemic measures, markers of inflammation (e.g., C-reactive protein and interleukin-6), oxidative stress, and liver enzymes. Blood pressure reductions range from approximately 2 to 15 mmHg for systolic blood pressure and 1 to 7 mmHg for diastolic blood pressure, with the magnitude influenced by dose, duration, and baseline risk profiles. While direct evidence linking flaxseed to the prevention of hypertension, metabolic syndrome, metabolic dysfunction-associated steatotic liver disease, type 2 diabetes, chronic kidney disease, and cardiovascular disease is limited, its bioactive components-ALA, lignans, and fiber-are strongly associated with reduced risks of these conditions. The benefits of flaxseed are mediated through multiple pathways, including anti-inflammatory and antioxidant effects, improved lipid levels, improved glucose metabolism and insulin sensitivity, modulation of gut microbiota, and enhanced vascular health. Beyond cardiometabolic outcomes, flaxseed may influence key biological processes relevant to aging, underscoring its potential to promote healthy aging and longevity. Optimal cardiometabolic benefits appear to be achieved with ground whole flaxseed at doses of >= 30 g/day for at least 12 weeks, particularly among individuals at high cardiometabolic risk. Future research should focus on elucidating flaxseed's mechanisms of action, clarifying its role in disease prevention, and refining dietary recommendations to harness its potential for cardiometabolic health and aging interventions.
C1 [Kunutsor, Setor K.; Jassal, Davinder S.; Ravandi, Amir] Univ Manitoba, St Boniface Hosp, Max Rady Coll Med, Rady Fac Hlth Sci,Dept Internal Med,Sect Cardiol, 409 Tache Ave, Winnipeg, MB R2H 2A6, Canada.
   [Ravandi, Amir] Univ Manitoba, Inst Cardiovasc Sci, Max Rady Coll Med, Rady Fac Hlth Sci,Dept Physiol & Pathophysiol, Winnipeg, MB, Canada.
   [Lehoczki, Andrea] Semmelweis Univ, Inst Prevent Med & Publ Hlth, Budapest, Hungary.
   [Lehoczki, Andrea] Semmelweis Univ, Doctoral Coll, Hlth Sci Program, Budapest, Hungary.
C3 University of Manitoba; Saint Boniface Hospital; Children's Hospital
   Research Institute of Manitoba; University of Manitoba; Semmelweis
   University; Semmelweis University
RP Kunutsor, SK (corresponding author), Univ Manitoba, St Boniface Hosp, Max Rady Coll Med, Rady Fac Hlth Sci,Dept Internal Med,Sect Cardiol, 409 Tache Ave, Winnipeg, MB R2H 2A6, Canada.
EM skk31@cantab.net
RI Lehoczki, Andrea/LQK-7571-2024; Kunutsor, Setor/H-9807-2019
OI KUNUTSOR, SETOR/0000-0002-2625-0273
FU Ministry of Innovation and Technology of Hungary from the National
   Research, Development and Innovation Fund [TKP2021-NKTA-47,
   RRF-2.3.1-21-2022-00003]; European University for Well-Being (EUniWell)
   program [101004093/EUniWell/EAC-A02-2019/EAC-A02-2019-1]; New National
   Excellence Program of the Ministry for Culture and Innovation from the
   source of the National Research, Development and Innovation Fund
   [EKOEP-2024-9]
FX AL was supported by TKP2021-NKTA-47, implemented with the support
   provided by the Ministry of Innovation and Technology of Hungary from
   the National Research, Development and Innovation Fund, financed under
   the TKP2021-NKTA funding scheme; by funding through the National
   Cardiovascular Laboratory Program (RRF-2.3.1-21-2022-00003) provided by
   the Ministry of Innovation and Technology of Hungary from the National
   Research, Development and Innovation Fund; the European University for
   Well-Being (EUniWell) program (grant agreement number:
   101004093/EUniWell/EAC-A02-2019/EAC-A02-2019-1) and by the EKOEP-2024-9
   New National Excellence Program of the Ministry for Culture and
   Innovation from the source of the National Research, Development and
   Innovation Fund. The funding sources had no role in the study design; in
   the collection, analysis and interpretation of data; in the writing of
   the report; and in the decision to submit the article for publication.
   The content is solely the responsibility of the authors and does not
   necessarily represent the official views of the funding agencies. The 4o
   version of ChatGPT, developed by OpenAI, was used as a language tool to
   refine our writing and enhance the clarity of our work.
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NR 185
TC 3
Z9 3
U1 9
U2 9
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 2509-2715
EI 2509-2723
J9 GEROSCIENCE
JI GeroScience
PD 2025 JAN 16
PY 2025
DI 10.1007/s11357-025-01512-0
EA JAN 2025
PG 29
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA S3E7E
UT WOS:001397103100001
PM 39821819
OA hybrid
DA 2025-06-11
ER

PT J
AU Newcomer, JW
AF Newcomer, John W.
TI Metabolic syndrome and mental illness
SO AMERICAN JOURNAL OF MANAGED CARE
LA English
DT Article
ID ANTIPSYCHOTIC MEDICATION TREATMENT; DIABETES-MELLITUS;
   CHRONIC-SCHIZOPHRENIA; EXCESS MORTALITY; CLOZAPINE USE; WEIGHT-GAIN;
   RISPERIDONE; OLANZAPINE; RISK; QUETIAPINE
AB Patients with mental illnesses such as schizophrenia and bipolar disorder have an increased prevalence of metabolic syndrome and its components, risk factors for cardiovascular disease and type 2 diabetes. Although the prevalence of obesity and other risk factors such as hyperglycemia are increasing in the general population, patients with major mental illnesses have an increased prevalence of overweight and obesity, hyperglycemia, dyslipidemia, an dyslipidemia, hypertension, and smoking, andsubstantially greater mortality, compared with the general population. Persons with major mental disorders lose 25 to 30 years of potential life in comparison with the general population, primarily due to premature cardiovascular mortality. The causes of increased cardiometabolic risk in this population can include nondisease-related factors such as poverty and reduced access to medical care, as well as adverse metabolic side effects associated with psychotropic medications, such as antipsychotic drugs. Individual antipsychotic medications are associated with well-defined risks of weight gain and related risks for adverse changes in glucose and lipid metabolism. Based on the medical risk profile of persons with major mental illnesses, and the evidence that certain medications can contribute to increased risk, screening and regular monitoring of metabolic parameters such as weight (body mass index), waist circumference, plasma glucose and lipids, and blood pressure are recommended to manage risk in this population. Treatment decisions should incorporate information about medical risk factors in general and cardiometabolic risk in particular. In addition to the implications for individual clinicians, the problem of disparity in meeting healthcare needs for persons with mental illness in comparison with the general population has become an important public policy concern, with recent recommendations from the National Association of State Mental Health Program Directors and the Institute of Medicine. This article provides an overview of cardiometabolic risk in patients with major mental illness and describes steps for risk reduction.
C1 [Newcomer, John W.] Washington Univ, Sch Med, Ctr Clin Studies, St Louis, MO 63110 USA.
C3 Washington University (WUSTL)
RP Newcomer, JW (corresponding author), Washington Univ, Sch Med, Ctr Clin Studies, 660 S Euclid, St Louis, MO 63110 USA.
EM newcomerj@wustl.edu
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NR 46
TC 183
Z9 210
U1 0
U2 16
PU MANAGED CARE & HEALTHCARE COMMUNICATIONS LLC
PI PLAINSBORO
PA 666 PLAINSBORO RD, STE 300, PLAINSBORO, NJ 08536 USA
SN 1088-0224
J9 AM J MANAG CARE
JI Am. J. Manag. Care
PD NOV
PY 2007
VL 13
IS 7
SU S
BP S170
EP S177
PG 8
WC Health Care Sciences & Services; Health Policy & Services; Medicine,
   General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Health Care Sciences & Services; General & Internal Medicine
GA 241RC
UT WOS:000251672500002
PM 18041878
DA 2025-06-11
ER

PT J
AU Kuka, P
   Bucova, M
   Penz, P
   Paulovicova, E
   Blazicek, P
   Atalay, M
   Lietava, J
AF Kuka, P.
   Bucova, M.
   Penz, P.
   Paulovicova, E.
   Blazicek, P.
   Atalay, M.
   Lietava, J.
TI HSP60, oxidative stress parameters and cardiometabolic risk markers in
   hypertensive and normotensive Slovak females
SO BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY
LA English
DT Article
DE atherosclerosis; HSP60; hypertension; mean arterial pressure; metabolic
   syndrome; oxidative stress
ID CORONARY-HEART-DISEASE; HUMAN HEAT-SHOCK-PROTEIN-60; SHOCK-PROTEIN;
   ANTIBODIES; ATHEROSCLEROSIS
AB Background: The aim of our study was to analyse the relationships between hypertension, HSP60, oxidative stress, lipid profile and cardiometabolic risk in 126 females with arterial hypertension (AH(+)) and 39 normotensive females (AH(-)).
   Results: Females with AH(+) were significantly older and more frequently suffered from ischemic heart disease, angina pectoris, prior MI, abdominal obesity, obesity, metabolic syndrome and diabetes mellitus, On the other hand, normotensive females smoked significantly more often. Plasma levels of HSP60 were similar in both AH(+) and AH(-). groups. However, hypertensive females exhibited almost two times lower values of oxidative glutation and lower levels of carbonyl protein, but significantly higher levels of homocysteine. In normotensive females, the total glutathione was the only parameter predicting females with the plasma level of HSP60 = 60 ng/ml. The independent predictors in hypertensive females were angina pectoris, triglycerides and the mean arterial pressure (MAP). MAP had also a borderline significance in normotensive females suggesting an association between HSP60 and blood pressure. MAP formed a J shaped curve with HSP60.
   Conclusion: Results suggest the association of blood pressure and heart shock protein 60 Kda in form of the J curve (Tab. 11, Fig. 3, Ref. 29). Full Text in free PDF www.bmj.sk.
C1 [Kuka, P.; Bucova, M.; Penz, P.; Paulovicova, E.; Blazicek, P.; Atalay, M.; Lietava, J.] Comenius Univ, Dept Internal Med 2, Fac Med, SK-81369 Bratislava, Slovakia.
C3 Comenius University Bratislava
RP Lietava, J (corresponding author), Comenius Univ, Dept Internal Med 2, Fac Med, Mickiewiczova 13, SK-81369 Bratislava, Slovakia.
EM jan.lietava@yahoo.com
RI Paulovicova, Ema/AAT-8869-2021
OI Paulovicova, Ema/0000-0002-7063-1487
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NR 30
TC 3
Z9 3
U1 0
U2 5
PU COMENIUS UNIV
PI BRATISLAVA I
PA SCH MEDICINE, SPITALSKA 24, BRATISLAVA I, SK-813 72, SLOVAKIA
SN 0006-9248
EI 1336-0345
J9 BRATISL MED J
JI Bratisl. Med. J.
PY 2010
VL 111
IS 10
BP 527
EP 534
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 681EH
UT WOS:000284293700001
PM 21125796
DA 2025-06-11
ER

PT J
AU Liu, F
   Hu, X
   Zhu, XL
   Dong, XY
   Ge, J
   Xu, SL
   Li, G
   Li, L
   Li, SG
   Wei, ZM
AF Liu, Fen
   Hu, Xing
   Zhu, Xiaoli
   Dong, Xinying
   Ge, Jie
   Xu, Shunlin
   Li, Gang
   Li, Lu
   Li, Shugang
   Wei, Zhimin
TI A community-based cross-sectional study of anxiety and metabolic
   syndrome
SO PSYCHOGERIATRICS
LA English
DT Article
DE anxiety; elderly; metabolic syndrome
ID SCHIZOPHRENIA; DEPRESSION; DISEASE; STRESS; RISK; INFLAMMATION;
   MECHANISMS; COVID-19; OBESITY; BIPOLAR
AB BackgroundThe prevalence of anxiety and other psychological disorders has increased during the COVID-19 pandemic, especially among the elderly. Anxiety and metabolic syndrome (MetS) may aggravate each other. This study further clarified the correlation between the two. MethodsAdopting a convenience sampling method, this study investigated 162 elderly people over 65 years of age in Fangzhuang Community, Beijing. All participants provided baseline data on sex, age, lifestyle, and health status. The Hamilton Anxiety Scale (HAMA) was used to assess anxiety. Blood samples, abdominal circumference, and blood pressure were used to diagnose MetS. The elderly were divided into MetS and control groups according to the diagnosis of MetS. Differences in anxiety between the two groups were analysed and further stratified by age and gender. Multivariate logistic regression analysis was used to analyse the possible risk factors for MetS. ResultsCompared with the control group, anxiety scores of the MetS group were statistically higher (Z = 4.78, P < 0.001). There was a significant correlation between anxiety levels and MetS (r = 0.353, P < 0.001). Multivariate logistic regression revealed that anxiety (possible anxiety vs no anxiety: odds ratio [OR] = 2.982, 95% confidence interval [CI] 1.295-6.969; definite anxiety vs no anxiety: OR = 14.573, 95%CI 3.675-57.788; P < 0.001) and BMI (OR = 1.504, 95% CI 1.275-1.774; P < 0.001) were possible risk factors for MetS. ConclusionThe elderly with MetS had higher anxiety scores. Anxiety may be a potential risk factor for MetS, which provides a new perspective on anxiety and MetS.
C1 [Liu, Fen; Hu, Xing; Li, Gang; Li, Lu; Wei, Zhimin] Hlth Serv Dept Guard Bur Joint Staff Dept, Beijing, Peoples R China.
   [Hu, Xing] Peking Univ, Hlth Sci Ctr, Grad Sch, Beijing, Peoples R China.
   [Zhu, Xiaoli; Dong, Xinying; Li, Shugang] Capital Med Univ, Sch Publ Hlth, Beijing, Peoples R China.
   [Ge, Jie; Xu, Shunlin] Peking Univ Third Hosp, Beijing, Peoples R China.
   [Li, Shugang] Capital Med Univ, Sch Publ Hlth, Dept Maternal & Children Hlth, 10 Xitoutiao,Youanmen St, Beijing 100069, Peoples R China.
C3 Peking University; Capital Medical University; Peking University;
   Capital Medical University
RP Wei, ZM (corresponding author), Hlth Serv Dept Guard Bur Joint Staff Dept, Beijing, Peoples R China.; Li, SG (corresponding author), Capital Med Univ, Sch Publ Hlth, Dept Maternal & Children Hlth, 10 Xitoutiao,Youanmen St, Beijing 100069, Peoples R China.
EM lishugang@ccmu.edu.cn; 51807124@qq.com
RI XL, zhu/GQR-1464-2022
FU National Health Commission [2020YB06]; Beijing High Level Public Health
   Technical Talents Training Plan [2023-3-005]
FX ACKNOWLEDGMENTS This work was supported by the National Health
   Commission (Grant No. 2020YB06) of China and the Beijing High Level
   Public Health Technical Talents Training Plan (Grant No. 2023-3-005). We
   also thank the participants of this study.
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NR 32
TC 0
Z9 0
U1 9
U2 18
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1346-3500
EI 1479-8301
J9 PSYCHOGERIATRICS
JI Psychogeriatrics
PD MAY
PY 2023
VL 23
IS 3
BP 450
EP 457
DI 10.1111/psyg.12953
EA MAR 2023
PG 8
WC Geriatrics & Gerontology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology; Psychiatry
GA E5GY3
UT WOS:000949366500001
PM 36932654
DA 2025-06-11
ER

PT J
AU Ghim, S
   Ku, B
AF Ghim, Seungbeen
   Ku, Byungmo
TI The prevalence of health problems and their association with physical
   activity in caregivers of children with disabilities: 2018 National
   Health Interview Survey
SO CHILD CARE HEALTH AND DEVELOPMENT
LA English
DT Article
DE mental health; mother; parents; physical activity; psychological health
ID QUALITY-OF-LIFE; METABOLIC SYNDROME; PARENTING STRESS; METAANALYSIS;
   DEPRESSION; BEHAVIORS; INSURANCE; OBESITY; AUTISM; CARE
AB Background Caregivers of children with disabilities often experience poor health. One way for caregivers to promote their own health may be to participate in physical activity (PA). Aims The purpose of this study was to examine the association between PA and psychological and physical health problems in caregivers of children with disabilities. Methods The 2018 National Health Interview Survey (NHIS) data were used, and 890 household representatives were identified as caregivers of children with disabilities. Based on the national PA guidelines, caregivers were classified into three groups: inactive (IA), aerobically active (AA), and aerobically and muscularly active (AMA). Results Multivariable logistic regression indicated that the AMA group had a lower likelihood of reporting depression compared to the IA group (OR: 0.73 [95% confidence interval: 0.54, 0.98]). The AMA group also had a lower likelihood of reporting back pain and obesity compared to the IA group (OR:0.69 [95% confidence interval: 0.56, 0.84] and OR:0.63 [95% confidence interval: 0.52, 0.76], respectively). Conclusions The results of the current study suggest that caregivers of children with disabilities may benefit from PA, especially from the combination of aerobic and muscle-strengthening PA.
C1 [Ghim, Seungbeen] Oregon State Univ, Coll Publ Hlth & Human Sci, Hlth Management & Policy, Corvallis, OR 97331 USA.
   [Ku, Byungmo] Nanyang Technol Univ, Phys Educ & Sports Sci Acad Grp, Natl Inst Educ, Singapore, Singapore.
C3 Oregon State University; Nanyang Technological University; National
   Institute of Education (NIE) Singapore
RP Ghim, S (corresponding author), Oregon State Univ, Coll Publ Hlth & Human Sci, Hlth Management & Policy, Corvallis, OR 97331 USA.
EM ghims@oregonstate.edu
RI Ku, Byungmo/AAH-1846-2020
OI Ku, Byungmo/0000-0002-0668-9190
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NR 45
TC 4
Z9 5
U1 1
U2 10
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0305-1862
EI 1365-2214
J9 CHILD CARE HLTH DEV
JI Child Care Health Dev.
PD MAR
PY 2022
VL 48
IS 2
BP 347
EP 357
DI 10.1111/cch.12934
EA DEC 2021
PG 11
WC Psychology, Developmental; Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Pediatrics
GA YY5FO
UT WOS:000730118700001
PM 34850443
DA 2025-06-11
ER

PT J
AU Marcus, MD
   Wildes, JE
AF Marcus, Marsha D.
   Wildes, Jennifer E.
TI Obesity: Is it a Mental Disorder?
SO INTERNATIONAL JOURNAL OF EATING DISORDERS
LA English
DT Review
ID ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; NATIONAL EPIDEMIOLOGIC SURVEY;
   INDUCED WEIGHT-GAIN; BODY-MASS INDEX; MAJOR DEPRESSIVE DISORDER;
   PSYCHIATRIC-DISORDERS; HARMFUL DYSFUNCTION; METABOLIC SYNDROME;
   ADOLESCENT DEPRESSION; NEURAL RESPONSES
AB Objective: Using Wakefield's conceptualization of mental disorder as "harmful mental dysfunction" (Wakefield, Am Psychol, 47, 373-388, 1992), we examined the evidence for including obesity as a mental disorder in DSM-V.
   Method: We searched computer data bases and examined reference lists from review articles published in the last 10 years to identify empirical papers relevant to the present review.
   Results: Obesity is a condition of heterogeneous etiology that is harmful for most individuals. However, there is scant evidence that obesity, in general, is caused by mental dysfunction. Although recent work examining the neurocircuitry of energy balance has suggested that mental dysfunction may be involved in the etiology of specific obesity phenotypes, findings are too preliminary to Support classification of obesity as a mental disorder. Nevertheless, there is evidence that obesity is related to mental disorder and many of the medications used to treat psychiatric illness.
   Discussion: There is little evidence for including obesity as a mental disorder in DSM-V. However, results confirm the importance of monitoring adiposity routinely among patients with psychiatric illness. (C) 2009 American Psychiatric Association.
C1 [Marcus, Marsha D.; Wildes, Jennifer E.] Univ Pittsburgh, Western Psychiat Inst & Clin, Pittsburgh, PA 15213 USA.
C3 Pennsylvania Commonwealth System of Higher Education (PCSHE); University
   of Pittsburgh; Western Psychiatric Institute & Clinic of UPMC
RP Marcus, MD (corresponding author), Univ Pittsburgh, Western Psychiat Inst & Clin, 3811 OHara St, Pittsburgh, PA 15213 USA.
EM marcusmd@upmc.edu
OI Wildes, Jennifer/0000-0003-0950-4347
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NR 154
TC 96
Z9 122
U1 0
U2 34
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0276-3478
EI 1098-108X
J9 INT J EAT DISORDER
JI Int. J. Eating Disord.
PD DEC
PY 2009
VL 42
IS 8
BP 739
EP 753
DI 10.1002/eat.20725
PG 15
WC Psychology, Clinical; Nutrition & Dietetics; Psychiatry; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Nutrition & Dietetics; Psychiatry
GA 526LF
UT WOS:000272289500006
PM 19610015
DA 2025-06-11
ER

PT J
AU Kuzminskaite, E
   Penninx, BWJH
   Van Harmelen, AL
   Elzinga, BM
   Hovens, JGFM
   Vinkers, CH
AF Kuzminskaite, Erika
   Penninx, Brenda W. J. H.
   Harmelen, Anne-Laura van
   Elzinga, Bernet M.
   Hovens, Jacqueline G. F. M.
   Vinkers, Christiaan H.
TI Childhood Trauma in Adult Depressive and Anxiety Disorders: An
   Integrated Review on Psychological and Biological Mechanisms in the
   NESDA Cohort
SO JOURNAL OF AFFECTIVE DISORDERS
LA English
DT Review
DE Childhood trauma; Childhood maltreatment; Depression, anxiety; Review
AB Background: Childhood trauma (CT) has adverse consequences on mental health across the lifespan. The understanding of how CT increases vulnerability for psychiatric disorders is growing. However, lack of an integrative approach to psychological and biological mechanisms of CT hampers further advancement. This review integrates CT findings across explanatory levels from a longitudinal adult cohort ? the Netherlands Study of Depression and Anxiety (NESDA).
   Methods: We reviewed all studies (k = 37) from the NESDA cohort (n = 2981) published from 2009 to 2020 containing CT findings related to psychopathology and potential psychological and biological mechanisms of CT.
   Results: CT was associated with a higher risk of anxiety and depressive disorders with the strongest associations in the comorbid group. CT predicted the onset of these disorders, recurrence, and poorer outcomes (more co morbidity and chronicity). CT was associated with maladaptive personality characteristics and cognitions (e.g., higher neuroticism and negative self-associations), mild stress systems dysregulations (heightened levels of cortisol and inflammation), advanced biological aging (increased epigenetic aging and telomere attrition), poorer lifestyle (higher smoking rate and body mass index), somatic health decline (e.g., increased metabolic syndrome dysregulations), and brain alterations (e.g., reduced mPFC volume and increased amygdala reactivity). Limitations: Literature review of one cohort using mixed analytical approaches.
   Conclusion: : CT impacts the functioning of the brain, mind, and body, which together may contribute to a higher vulnerability for affective disorders. It is essential to employ an integrative approach combining different sources of data to understand the mechanisms of CT better.
C1 [Kuzminskaite, Erika; Penninx, Brenda W. J. H.; Vinkers, Christiaan H.] Vrije Univ, Amsterdam Publ Hlth, Dept Psychiat GGZ inGeest, Amsterdam UMC Locat VUmc, Amsterdam, Netherlands.
   [Kuzminskaite, Erika; Penninx, Brenda W. J. H.; Vinkers, Christiaan H.] Amsterdam Neurosci Res Inst, Amsterdam, Netherlands.
   [Harmelen, Anne-Laura van] Leiden Univ, Dept Educ & Child Studies, Leiden, Netherlands.
   [Harmelen, Anne-Laura van; Elzinga, Bernet M.] Leiden Univ, Leiden Inst Brain & Cognit LIBC, Leiden, Netherlands.
   [Harmelen, Anne-Laura van] Univ Cambridge, Dept Psychiat, Cambridge, England.
   [Elzinga, Bernet M.] Leiden Univ, Inst Psychol, Clin Psychol Unit, Leiden, Netherlands.
   [Hovens, Jacqueline G. F. M.] Leiden UMC, Dept Psychiat, Leiden, Netherlands.
   [Vinkers, Christiaan H.] Vrije Univ, Dept Anat & Neurosci, Amsterdam UMC Locat VUmc, Amsterdam, Netherlands.
C3 Vrije Universiteit Amsterdam; Leiden University - Excl LUMC; Leiden
   University; Leiden University; Leiden University - Excl LUMC; University
   of Cambridge; Leiden University - Excl LUMC; Leiden University; Leiden
   University; Leiden University Medical Center (LUMC); Vrije Universiteit
   Amsterdam
RP Kuzminskaite, E (corresponding author), Vrije Univ, Amsterdam UMC Locat VUmc, Dept Psychiat GGZ inGeest, Oldenaller 1, NL-1081 HJ Amsterdam, Netherlands.
EM e.kuzminskaite@ggzingeest.nl; b.penninx@amsterdamumc.nl;
   a.van.harmelen@fsw.leidenuniv.nl; elzinga@fsw.leidenuniv.nl;
   j.g.f.m.hovens@lumc.nl; c.vinkers@amsterdamumc.nl
RI Kuzminskaite, Erika/JGC-6829-2023; Vinkers, Christiaan/AAV-1720-2020;
   van Harmelen, Anne-Laura/AGH-9307-2022; Penninx, Brenda WJH/S-7627-2017
OI van Harmelen, Anne-Laura/0000-0003-1108-2921; Vinkers,
   Christiaan/0000-0003-3698-0744; Penninx, Brenda WJH/0000-0001-7779-9672;
   Kuzminskaite, Erika/0000-0002-5686-3935
FU Geestkracht program of the Netherlands Organization for Health Research
   and Development (ZonMw) [10-000-1002]; VU University Medical Center; GGZ
   inGeest; Leiden University Medical Center; Leiden University; GGZ
   Rivierduinen; University Medical Center Groningen; University of
   Groningen; Lentis; GGZ Friesland; GGZ Drenthe; Rob Giel
   Onderzoekscentrum
FX The infrastructure for the NESDA study (www.nesda.nl) is funded through
   the Geestkracht program of the Netherlands Organization for Health
   Research and Development (ZonMw, grant number: 10-000-1002) and
   financial contributions by participating universities and mental health
   care organizations (VU University Medical Center, GGZ inGeest, Leiden
   University Medical Center, Leiden University, GGZ Rivierduinen,
   University Medical Center Groningen, University of Groningen, Lentis,
   GGZ Friesland, GGZ Drenthe, Rob Giel Onderzoekscentrum).
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NR 99
TC 81
Z9 91
U1 3
U2 30
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-0327
EI 1573-2517
J9 J AFFECT DISORDERS
JI J. Affect. Disord.
PD MAR 15
PY 2021
VL 283
BP 179
EP 191
DI 10.1016/j.jad.2021.01.054
EA FEB 2021
PG 13
WC Clinical Neurology; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Psychiatry
GA RB1RC
UT WOS:000631892500021
PM 33561798
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Dimina, L
   Mariotti, F
AF Dimina, Laurianne
   Mariotti, Francois
TI The Postprandial Appearance of Features of Cardiometabolic Risk: Acute
   Induction and Prevention by Nutrients and Other Dietary Substances
SO NUTRIENTS
LA English
DT Review
DE metabolic syndrome; postprandial; endothelial function; oxidative
   stress; nuts; berries
ID HIGH-FAT MEAL; FACTOR-KAPPA-B; ENDOTHELIUM-DEPENDENT RELAXATION; OXYGEN
   SPECIES GENERATION; FLOW-MEDIATED DILATATION; NITRIC-OXIDE PRODUCTION;
   MUSCLE GLUCOSE-UPTAKE; FLAVANOL-RICH COCOA; INSULIN-RESISTANCE;
   OXIDATIVE STRESS
AB The purpose of this review is to provide an overview of diets, food, and food components that affect postprandial inflammation, endothelial function, and oxidative stress, which are related to cardiometabolic risk. A high-energy meal, rich in saturated fat and sugars, induces the transient appearance of a series of metabolic, signaling and physiological dysregulations or dysfunctions, including oxidative stress, low-grade inflammation, and endothelial dysfunction, which are directly related to the amplitude of postprandial plasma triglycerides and glucose. Low-grade inflammation and endothelial dysfunction are also known to cluster together with insulin resistance, a third risk factor for cardiovascular diseases (CVD) and type-II diabetes, thus making a considerable contribution to cardiometabolic risk. Because of the marked relevance of the postprandial model to nutritional pathophysiology, many studies have investigated whether adding various nutrients and other substances to such a challenge meal might mitigate the onset of these adverse effects. Some foods (e.g., nuts, berries, and citrus), nutrients (e.g., l-arginine), and other substances (various polyphenols) have been widely studied. Reports of favorable effects in the postprandial state have concerned plasma markers for systemic or vascular pro-inflammatory conditions, the activation of inflammatory pathways in plasma monocytes, vascular endothelial function (mostly assessed using physiological criteria), and postprandial oxidative stress. Although the literature is fragmented, this topic warrants further study using multiple endpoints and markers to investigate whether the interesting candidates identified might prevent or limit the postprandial appearance of critical features of cardiometabolic risk.
C1 [Dimina, Laurianne; Mariotti, Francois] Univ Paris Saclay, UMR PNCA, AgroParisTech, INRA, F-75005 Paris, France.
C3 AgroParisTech; Universite Paris Saclay; INRAE
RP Mariotti, F (corresponding author), Univ Paris Saclay, UMR PNCA, AgroParisTech, INRA, F-75005 Paris, France.
EM francois.mariotti@agroparistech.fr
RI ; Mariotti, Francois/F-9651-2017
OI Dimina, Laurianne/0000-0002-3192-3110; Mariotti,
   Francois/0000-0002-4516-3853
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NR 216
TC 29
Z9 30
U1 0
U2 10
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD SEP
PY 2019
VL 11
IS 9
AR 1963
DI 10.3390/nu11091963
PG 23
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA JA6PP
UT WOS:000487964600132
PM 31438565
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Carroll, SJ
   Dale, MJ
   Niyonsenga, T
   Taylor, AW
   Daniel, M
AF Carroll, Suzanne J.
   Dale, Michael J.
   Niyonsenga, Theophile
   Taylor, Anne W.
   Daniel, Mark
TI Associations between area socioeconomic status, individual mental
   health, physical activity, diet and change in cardiometabolic risk
   amongst a cohort of Australian adults: A longitudinal path analysis
SO PLOS ONE
LA English
DT Article
ID ALL-CAUSE MORTALITY; CARDIOVASCULAR-DISEASE; NEIGHBORHOOD
   CHARACTERISTICS; SOCIAL DETERMINANTS; BUILT ENVIRONMENT; MAJOR
   DEPRESSION; OBESITY; POPULATION; MULTILEVEL; SF-36
AB Presumed pathways from environments to cardiometabolic risk largely implicate health behaviour although mental health may play a role. Few studies assess relationships between these factors. This study estimated associations between area socioeconomic status (SES), mental health, diet, physical activity, and 10-year change in glycosylated haemoglobin (HbAic), comparing two proposed path structures: 1) mental health and behaviour functioning as parallel mediators between area SES and HbAic; and 2) a sequential structure where mental health influences behaviour and consequently HbAic. Three waves (10 years) of population-based biomedical cohort data were spatially linked to census data based on participant residential address. Area SES was expressed at baseline using an established index (SEIFA-IEO). Individual behavioural and mental health information (Wave 2) included diet (fruit and vegetable servings per day), physical activity (meets/does not meet recommendations), and the mental health component score of the 36-item Short Form Health Survey. HbAic was measured at each wave. Latent variable growth models with a structural equation modelling approach estimated associations within both parallel and sequential path structures. Models were adjusted for age, sex, employment status, marital status, education, and smoking. The sequential path model best fit the data. HbAic worsened over time. Greater area SES was statistically significantly associated with greater fruit intake, meeting physical activity recommendations, and had a protective effect against increasing HbAic directly and indirectly through physical activity behaviour. Positive mental health was statistically significantly associated with greater fruit and vegetable intakes and was indirectly protective against increasing HbAic through physical activity. Greater SES was protective against increasing HbAic. This relationship was partially mediated by physical activity but not diet. A protective effect of mental health was exerted through physical activity. Public health interventions should ensure individuals residing in low SES areas, and those with poorer mental health are supported in meeting physical activity recommendations.
C1 [Carroll, Suzanne J.; Dale, Michael J.; Daniel, Mark] Univ Canberra, Hlth Res Inst, Australian Geospatial Hlth Lab, Canberra, ACT, Australia.
   [Niyonsenga, Theophile] Univ Canberra, Hlth Res Inst, Canberra, ACT, Australia.
   [Taylor, Anne W.] Univ Adelaide, Discipline Med, Adelaide, SA, Australia.
   [Daniel, Mark] Univ Melbourne, St Vincents Hosp, Dept Med, Fitzroy, Vic, Australia.
C3 University of Canberra; University of Canberra; University of Adelaide;
   University of Melbourne; St Vincent's Health; St Vincent's Hospital
   Melbourne; NSW Health; St Vincents Hospital Sydney
RP Carroll, SJ (corresponding author), Univ Canberra, Hlth Res Inst, Australian Geospatial Hlth Lab, Canberra, ACT, Australia.
EM suzanne.carroll@canberra.edu.au
RI Dale, Michael/K-9820-2019; Carroll, Suzanne/AAN-1552-2020; Niyonsenga,
   Theophile/C-3759-2014; Carroll, Suzanne J/F-4194-2013
OI Niyonsenga, Theophile/0000-0002-6723-0316; Dale,
   Michael/0000-0003-4285-1842; Carroll, Suzanne J/0000-0002-9767-2860
FU National Health and Medical Research Council (NHMRC) [570150, 631917]
FX MD received funding from National Health and Medical Research Council
   (NHMRC, https://www.nhmrc.gov.au/) grants (#570150 and #631917). The
   NHMRC had no involvement with study design, data collection, analysis
   and interpretation of results, writing this manuscript or choice of
   journal.
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NR 83
TC 17
Z9 18
U1 0
U2 20
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAY 29
PY 2020
VL 15
IS 5
AR e0233793
DI 10.1371/journal.pone.0233793
PG 16
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Science & Technology - Other Topics
GA LU1WS
UT WOS:000537552800181
PM 32470027
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Cha, L
   Montoya, AK
   Schetter, CD
   Sumner, JA
AF Cha, Leah
   Montoya, Amanda K.
   Schetter, Christine Dunkel
   Sumner, Jennifer A.
TI Neighborhood disorder and social cohesion: A longitudinal investigation
   of links with maternal cardiometabolic risk one year postpartum
SO JOURNAL OF PSYCHOSOMATIC RESEARCH
LA English
DT Article
DE Neighborhoods; Cohesion; Disorder; Postpartum; Cardiometabolic risk;
   Distress; Physical activity
ID PHYSICAL-ACTIVITY; DEPRESSIVE SYMPTOMS; WOMEN; HEALTH; PREGNANCY;
   IMPACT; ASSOCIATIONS; MULTILEVEL; DISTRESS; BARRIERS
AB Objective: Neighborhood characteristics can influence cardiometabolic health, including during the perinatal period. However, maternal health research has largely examined the influence of objective neighborhood measures, limiting insights into psychological and social processes. We examined associations of perceived neighborhood disorder and social cohesion with maternal cardiometabolic risk 1 year postpartum and explored potential pathways of psychological distress and physical activity. Methods: A predominantly low-income sample of Black, Latina, and White postpartum women (n = 987) were participants in the Community Child Health Network study. Women reported on neighborhood characteristics at 1 month postpartum and on symptoms of depression, anxiety, and posttraumatic stress disorder and physical activity at 6 months postpartum. Biometrics and biological samples were collected at 1 year postpartum, including blood pressure, height, weight, and dried blood spots for cardiometabolic biomarkers (e.g., C-reactive protein, glycosylated hemoglobin). In this pre-registered study, we used structural equation modeling to estimate latent variables for disorder, social cohesion, distress, physical activity, and cardiometabolic risk. We fit a parallel mediation model to test associations between latent neighborhood factors at 1 month postpartum, distress and physical activity at 6 months postpartum, and cardiometabolic risk at 1 year postpartum. Results: Greater social cohesion, but not disorder, was significantly associated with lower distress and greater physical activity. However, there were no significant associations between disorder or social cohesion with subsequent cardiometabolic risk nor evidence for indirect effects of distress or physical activity. Conclusion: Results suggest that social cohesion may be more pertinent than disorder for health-relevant behavioral mechanisms in postpartum women.
C1 [Cha, Leah; Montoya, Amanda K.; Schetter, Christine Dunkel; Sumner, Jennifer A.] Univ Calif Los Angeles, Dept Psychol, 1285 Psychol Bldg,Box 951563, Los Angeles, CA 90095 USA.
C3 University of California System; University of California Los Angeles
RP Cha, L (corresponding author), Univ Calif Los Angeles, Dept Psychol, 1285 Psychol Bldg,Box 951563, Los Angeles, CA 90095 USA.
EM leah.cha@ucla.edu; akmontoya@ucla.edu; dunkel@psych.ucla.edu;
   jsumner@psych.ucla.edu
RI Montoya, Amanda/AAR-4439-2021
FU Eunice Kennedy Shriver National Institute of Child Health and Human
   Development [U HD44207, U HD44219, U HD44226, U HD44245, U HD44253, U
   HD54791, U HD54019, U HD44226-05S1, U HD44245-06S1, R03 HD59584];
   National Institute for Nursing Research [U NR008929]; National Heart,
   Lung, and Blood Institute [R01HL139614, R01HL160850]
FX The Community Child Health Network (CCHN) is supported by the Eunice
   Kennedy Shriver National Institute of Child Health and Human Development
   (U HD44207, U HD44219, U HD44226, U HD44245, U HD44253, U HD54791, U
   HD54019, U HD44226-05S1, U HD44245-06S1, R03 HD59584) and the National
   Institute for Nursing Research (U NR008929) . JAS is supported by grants
   from the National Heart, Lung, and Blood Institute (R01HL139614,
   R01HL160850) . The authors have no conflicts of interest to report.
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NR 61
TC 0
Z9 0
U1 2
U2 2
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0022-3999
EI 1879-1360
J9 J PSYCHOSOM RES
JI J. Psychosomat. Res.
PD FEB
PY 2025
VL 189
AR 112012
DI 10.1016/j.jpsychores.2024.112012
EA DEC 2024
PG 9
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA R5T1Z
UT WOS:001392063200001
PM 39700651
DA 2025-06-11
ER

PT J
AU Robins, JL
   Kliewer, W
AF Robins, Jo Lynne
   Kliewer, Wendy
TI Stress and Coping Profiles and Cardiometabolic Risk in Low-Income
   African American Women
SO JOURNAL OF WOMENS HEALTH
LA English
DT Article
DE stress; coping; cardiometabolic risk; adjustment profiles; African
   American Women
ID SHIFT-AND-PERSIST; CARDIOVASCULAR-DISEASE; SOCIOECONOMIC-STATUS;
   DRUG-USE; MYOCARDIAL-INFARCTION; URBAN ADOLESCENTS; HEART-DISEASE; 52
   COUNTRIES; STROKE; INFLAMMATION
AB Background: The complex interplay of psychological stress appraisal, biology, chronically stressful environments, and individual coping mechanisms can impact and tax physiological adaptive processes. This can result in increased cardiometabolic risk (CMR), type 2 diabetes, and cardiovascular disease. Underlying mechanisms are not entirely clear and appear to differ significantly based on age, sex, race, and ethnicity. Purpose: This cross-sectional descriptive study explored stress profiles of psychological and behavioral adjustment to determine the extent to which patterns of stressors, coping, and CMR differentiated these profiles. Materials and Methods: African American (AA) women (N = 110; M age = 38.61 years, SD = 6.94 years) were recruited from low-income communities and participated in two home visits to complete stress and coping and cardiovascular risk measures. Results: Three distinct stress and coping adjustment profiles were associated with differences in CMR. The "holding steady" profile had less insulin resistance (IR) and substance use compared to "high substance users" and "high internalizers" profiles. Women who were "holding steady" used less avoidant coping than "high internalizers." Conclusions: Less favorable adjustment processes were associated with IR, as well as significantly higher levels of avoidant coping and substance use. In AA women, awareness of and attention to stress and coping patterns may help attenuate CMR.
C1 [Robins, Jo Lynne] Virginia Commonwealth Univ, Sch Nursing, Dept Adult Hlth & Nursing Syst, POB 980567, Richmond, VA 23298 USA.
   [Kliewer, Wendy] Virginia Commonwealth Univ, Dept Psychol, Coll Humanities & Sci, Box 2018, Richmond, VA 23284 USA.
C3 Virginia Commonwealth University; Virginia Commonwealth University
RP Robins, JL (corresponding author), Virginia Commonwealth Univ, Sch Nursing, Dept Adult Hlth & Nursing Syst, POB 980567, Richmond, VA 23298 USA.
EM jwrobins@vcu.edu
OI Kliewer, Wendy/0000-0003-0046-203X
FU VCU Presidential Research Quest Fund
FX The authors acknowledge The VCU Presidential Research Quest Fund, which
   provided funding for this study. The authors also thank their dedicated
   research teams and the research participants; this work would not have
   been possible without each of them.
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NR 47
TC 7
Z9 8
U1 0
U2 5
PU MARY ANN LIEBERT, INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-9996
EI 1931-843X
J9 J WOMENS HEALTH
JI J. Womens Health
PD MAY 1
PY 2019
VL 28
IS 5
BP 636
EP 645
DI 10.1089/jwh.2017.6904
EA NOV 2018
PG 10
WC Public, Environmental & Occupational Health; Medicine, General &
   Internal; Obstetrics & Gynecology; Women's Studies
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; General & Internal
   Medicine; Obstetrics & Gynecology; Women's Studies
GA HY5PL
UT WOS:000450758900001
PM 30461339
DA 2025-06-11
ER

PT J
AU Perez-Cornago, A
   Lopez-Legarrea, P
   de la Iglesia, R
   Lahortiga, F
   Martinez, JA
   Zulet, MA
AF Perez-Cornago, Aurora
   Lopez-Legarrea, Patricia
   de la Iglesia, Rocio
   Lahortiga, Francisca
   Alfredo Martinez, J.
   Angeles Zulet, M.
TI Longitudinal relationship of diet and oxidative stress with depressive
   symptoms in patients with metabolic syndrome after following a weight
   loss treatment: The RESMENA project
SO CLINICAL NUTRITION
LA English
DT Article
DE Depression; Caloric restriction; Omega-3; Folate; Malondialdehyde;
   Metabolic syndrome
ID CARDIOVASCULAR-DISEASE; FATTY-ACIDS; PATTERN; ASSOCIATION; ADHERENCE;
   WOMEN; FRUIT
AB Background & aim: Metabolic syndrome and depression seem to share some common underlying mechanisms, although less is known about the impact of metabolic syndrome dietary treatments on depression. This study examined the association between a hypocaloric treatment designed to reduce metabolic syndrome features in self-perceived depression and the potential involvement of dietary components and oxidative stress changes.
   Methods: Analyses were based on volunteers (n = 55) with metabolic syndrome (age 50 +/- 1 y.o.; 38M/17F), where depressive symptoms were assessed using the Beck Depression Inventory. Participants followed two hypocaloric diets (control diet and RESMENA diet) with the same energy restriction (-30% TCV) for six months. Depressive symptoms, dietary records, anthropometrical measurements, biochemical parameters and oxidative stress levels were analysed.
   Results: Both diets improved self-perceived depression similarly (p = 0.528). Participants with lower depressive symptoms at baseline reported a significantly higher intake of omega-3 polyunsaturated fatty acids (p trend = 0.002). Interestingly, after adjusting for potential confounders, the increase in folate consumption (p = 0.011) and the decrease in plasma malondialdehyde levels (p = 0.012) throughout the intervention, were associated with the improvement in depressive symptoms.
   Conclusions: A higher intake of folate and a decline in malondialdehyde plasma levels during a weight loss intervention, were related to improvements in manifestations of depression (www.clinicaltrials.gov; NCT01087086). (C) 2013 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.
C1 [Perez-Cornago, Aurora; Lopez-Legarrea, Patricia; de la Iglesia, Rocio; Alfredo Martinez, J.; Angeles Zulet, M.] Univ Navarra, Dept Nutr Food Sci & Physiol, Pamplona 31008, Spain.
   [Lahortiga, Francisca] Univ Navarra, Dept Psychiat & Med Psychol, Pamplona 31008, Spain.
   [Alfredo Martinez, J.; Angeles Zulet, M.] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr CIBERObn, Madrid, Spain.
C3 University of Navarra; University of Navarra; Instituto de Salud Carlos
   III; CIBER - Centro de Investigacion Biomedica en Red; CIBEROBN
RP Martinez, JA (corresponding author), Univ Navarra, Dept Nutr Food Sci & Physiol, C Irunlarrea 1, Pamplona 31008, Spain.
EM apcornago@alumni.unav.es; pllegarrea@alumni.unav.es;
   rdelaiglesi@alumni.unav.es; flahortiga@unav.es; jalftmtz@unav.es;
   mazulet@unav.es
RI de la Iglesia, Rocio/ABC-6189-2020; Perez-Cornago, Aurora/C-1097-2016;
   Martinez Hernandez, J Alfredo/K-8709-2014; Zulet, M.
   Angeles/H-1317-2017; Lahortiga-Ramos, Francisca/H-9363-2017
OI Perez-Cornago, Aurora/0000-0002-5652-356X; Martinez Hernandez, J
   Alfredo/0000-0001-5218-6941; de la Iglesia, Rocio/0000-0002-7472-3565;
   Zulet, M. Angeles/0000-0002-3926-0892; Lahortiga-Ramos,
   Francisca/0000-0001-7624-6902
FU Health Department of the Government of Navarra [48/2009]; Linea Especial
   about Nutrition, Obesity and Health (University of Navarra) [LE/97];
   CIBERobn scheme; RETICS scheme
FX This study was supported by the Health Department of the Government of
   Navarra (48/2009) and the Linea Especial about Nutrition, Obesity and
   Health (University of Navarra LE/97). The support from CIBERobn and
   RETICS schemes is gratefully accredited.
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NR 30
TC 30
Z9 32
U1 0
U2 15
PU CHURCHILL LIVINGSTONE
PI EDINBURGH
PA JOURNAL PRODUCTION DEPT, ROBERT STEVENSON HOUSE, 1-3 BAXTERS PLACE,
   LEITH WALK, EDINBURGH EH1 3AF, MIDLOTHIAN, SCOTLAND
SN 0261-5614
EI 1532-1983
J9 CLIN NUTR
JI Clin. Nutr.
PD DEC
PY 2014
VL 33
IS 6
BP 1061
EP 1067
DI 10.1016/j.clnu.2013.11.011
PG 7
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA AY1OO
UT WOS:000347362400019
PM 24314875
DA 2025-06-11
ER

PT J
AU Fadini, GP
   Agostini, C
   Boscaro, E
   Avogaro, A
AF Fadini, Gian Paolo
   Agostini, Carlo
   Boscaro, Elisa
   Avogaro, Angelo
TI Mechanisms and Significance of Progenitor Cell Reduction in the
   Metabolic Syndrome
SO METABOLIC SYNDROME AND RELATED DISORDERS
LA English
DT Review
ID CORONARY-ARTERY-DISEASE; CARDIOVASCULAR EVENTS; OXIDATIVE STRESS;
   ESSENTIAL-HYPERTENSION; INDUCED ANGIOGENESIS; ENDOTHELIAL FUNCTION;
   IN-VIVO; NUMBER; RISK; ATHEROSCLEROSIS
AB Bone marrow-derived progenitor cells are involved in the homeostasis of the cardiovascular system through differentiation into endothelium, smooth muscle, and cardiomyocytes. Alterations of these extremely plastic cells have been recognized as both markers of cardiovascular risk and pathophysiological links between risk factors and development of atherosclerosis. Metabolic syndrome, as a cluster of well-defined cardiovascular risk factors, represents a strong predictor of cardiovascular events and death. Moreover, components of the syndrome interact with one another and synergistically increase this risk. Here we describe all metabolic syndrome components as being characterized by alterations in circulating progenitor cells, especially endothelial cells. We also highlight how endothelial progenitors may mediate the interactions between cardiometabolic risk factors in a complex interplay and discuss potential implications for prevention and therapy.
C1 [Fadini, Gian Paolo] Univ Padua, Sch Med, Dept Clin & Expt Med, Div Metab, Padua, Italy.
C3 University of Padua
RP Fadini, GP (corresponding author), Univ Padua, Sch Med, Dept Clin & Expt Med, Div Metab, Padua, Italy.
EM gianpaolofadini@hotmail.com
RI Fadini, Gian/M-4575-2019; Avogaro, Angelo/S-3808-2016; Agostini,
   Carlo/J-3103-2012
OI FADINI, GIAN PAOLO/0000-0002-6510-2097; AVOGARO,
   ANGELO/0000-0002-1177-0516; Agostini, Carlo/0000-0001-7786-3574
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NR 65
TC 17
Z9 21
U1 0
U2 1
PU MARY ANN LIEBERT INC
PI NEW ROCHELLE
PA 140 HUGUENOT STREET, 3RD FL, NEW ROCHELLE, NY 10801 USA
SN 1540-4196
J9 METAB SYNDR RELAT D
JI Metab. Syndr. Relat. Disord.
PD FEB
PY 2009
VL 7
IS 1
BP 5
EP 10
DI 10.1089/met.2008.0067
PG 6
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 418SO
UT WOS:000264169200002
PM 19183074
DA 2025-06-11
ER

PT J
AU Gradinaru, D
   Khaddour, H
   Margina, D
   Ungurianu, A
   Borsa, C
   Ionescu, C
   Prada, GI
   Usher, J
   Elshimali, Y
AF Gradinaru, Daniela
   Khaddour, Husseina
   Margina, Denisa
   Ungurianu, Anca
   Borsa, Claudia
   Ionescu, Cristina
   Prada, Gabriel-Ioan
   Usher, Joshua
   Elshimali, Yahya
TI Insulin-Leptin Axis, Cardiometabolic Risk and Oxidative Stress in
   Elderly with Metabolic Syndrome
SO EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
LA English
DT Article
DE insulin-leptin axis; metabolic syndrome; oxidative stress; elderly
ID LEPTIN/ADIPONECTIN RATIO; ASSOCIATION; RESISTANCE; GLUCOSE; PREVALENCE;
   ADIPOKINES; PHENOTYPES; PROTEIN; OBESITY; MODEL
AB Insulin and leptin have an overlapping anorexigenic action as well as opposite effects on glucose and lipid metabolism. The study focuses on the biochemical and clinical relevance of new indices of insulin-leptin axis utilized in the study of the relationships between leptinemia, insulin sensitivity and oxidative stress, in elderly subjects with metabolic syndrome. We conducted clinical studies on elderly people with metabolic syndrome versus control subjects by creating new insulin-adipogenic indices, namely Insulin-to-Leptin Ratio (ILR) and Insulin-Adipogenic Resistance index(IAR-index). Inflammation and oxidative stress biomarkers evaluated were the high-sensitivity C-reactive protein (hsCRP), the advanced oxidation protein products (AOPP), and the serum antioxidant capacity measured as ferric reducing antioxidant potential (FRAP). The metabolic syndrome group showed significantly (p < 0.01) lower levels of ILR and not significant (p = 0.09) higher values of IAR-index, as compared to the control group. In metabolic syndrome subjects, the IAR-index was significantly positively correlated with uric acid (r = 0.313, p < 0.05), FRAP (r = 0.347, p < 0.05) and AOPP (r = 0.677, p < 0.01), and negatively correlated with HDL-cholesterol (r = -0.340, p < 0.05) as well as with the ratio FRAP/uric acid (r= -0.315, p<0.05). ILR and IAR-index reflected the biological state of adipose and pancreatic beta-cells and seem to depict the adipo-insular axis status related to metabolic and oxidative stress better than individual markers. Therefore, ILR and IAR-index could represent integrated high-potential biomarkers for disease and patient stratification.
C1 [Gradinaru, Daniela; Khaddour, Husseina; Margina, Denisa; Ungurianu, Anca] Carol Davila Univ Med & Pharm, Fac Pharm, Dept Biochem, Bucharest, Romania.
   [Borsa, Claudia; Ionescu, Cristina; Prada, Gabriel-Ioan] Ana Aslan Natl Inst Gerontol & Geriatr, Bucharest, Romania.
   [Khaddour, Husseina] Univ Damascus, Fac Pharm, Dept Biochem, Damascus, Syria.
   [Usher, Joshua; Elshimali, Yahya] Liquid Genom Inc, Torrance, CA USA.
   [Usher, Joshua; Elshimali, Yahya] Univ Southern Calif, Norris Comprehens Canc Ctr, Los Angeles, CA USA.
   [Elshimali, Yahya] Charles R Drew Univ Med & Sci, Div Canc Res & Training, Dept Internal Med, 1621 E 120th St, Los Angeles, CA 90059 USA.
C3 Carol Davila University of Medicine & Pharmacy; National Institute of
   Gerontology & Geriatrics "Ana Aslan"; Damascus University; University of
   Southern California; Charles R. Drew University of Medicine & Science
RP Margina, D (corresponding author), Carol Davila Univ Med & Pharm, Dept Biochem, 6 Taian Vuia St,Sect 2, Bucharest 020956, Romania.
EM denisa.margina@umfcd.ro
RI Prada, Gabriel/B-8448-2016; Gradinaru, Daniela/A-4952-2019; Ungurianu,
   Anca/U-5657-2019; Margina, Denisa/J-7312-2013
OI Ungurianu, Anca/0000-0002-6887-1035; Prada, Gabriel -
   Ioan/0000-0002-4762-9581; Margina, Denisa/0000-0003-3289-147X
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NR 42
TC 16
Z9 16
U1 0
U2 5
PU JOHANN AMBROSIUS BARTH VERLAG MEDIZINVERLAGE HEIDELBERG GMBH
PI STUTTGART
PA RUEDIGERSTR 14, D-70469 STUTTGART, GERMANY
SN 0947-7349
EI 1439-3646
J9 EXP CLIN ENDOCR DIAB
JI Exp. Clin. Endocrinol. Diabet.
PD JUL
PY 2018
VL 126
IS 7
BP 445
EP 452
DI 10.1055/s-0043-123825
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA GL8NT
UT WOS:000437479900005
PM 29421825
DA 2025-06-11
ER

PT J
AU Petrova, D
   Ubago-Guisado, E
   Garcia-Retamero, R
   Redondo-Sanchez, D
   Perez-Gomez, B
   Catena, A
   Caparros-Gonzalez, RA
   Sanchez, MJ
AF Petrova, Dafina
   Ubago-Guisado, Esther
   Garcia-Retamero, Rocio
   Redondo-Sanchez, Daniel
   Perez-Gomez, Beatriz
   Catena, Andres
   Caparros-Gonzalez, Rafael A.
   Sanchez, Maria Jose
TI Allostatic Load and Depression Symptoms in Cancer Survivors: A National
   Health and Nutrition Examination Survey Study
SO CANCER NURSING
LA English
DT Article
DE Allostatic load; Biomarkers; Cancer nursing; Cancer survivors;
   Depression; Mental health; Stress
ID DISORDER; STRESS; PHQ-9
AB Background: Individuals with cancer often experience stress throughout the cancer trajectory and have a high risk of experiencing depression. Objective: The aim of this study was to examine the relationship between allostatic load (AL), a measure of cumulative stress-related physiologic dysregulation of different body systems, and symptoms of depression in cancer survivors. Methods: Participants were 294 adult cancer survivors from the US National Health and Nutrition Examination Survey (NHANES 2007-2018). Allostatic load was measured using 14 indicators representing cardiometabolic risk, glucose metabolism, cardiopulmonary functioning, parasympathetic functioning, and inflammation. Depressive symptoms were measured with the Patient Health Questionnaire-9. The relationship between AL and depressive symptoms was investigated using multiple regression adjusted for diverse sociodemographic and diagnosis variables. Results: Higher AL was associated with higher depressive symptom scores. The higher risk of depression was concentrated among those survivors in the highest AL quartile, with 21% (95% confidence interval, 11%-32%) of survivors presenting a high risk of depression compared with 8% to 11% of survivors in the lower quartiles. In exploratory analyses, the relationship between AL and depressive symptoms was only significant among survivors with a lower income. In contrast, in survivors in the highest income group, depressive symptoms were lower and unrelated to AL. Conclusion: High AL is associated with more depressive symptoms among cancer survivors.
C1 [Petrova, Dafina] ibs GRANADA, Inst Invest Biosanit, Granada, Spain.
   [Petrova, Dafina; Ubago-Guisado, Esther; Redondo-Sanchez, Daniel] Escuela Andaluza Salud Publ, Granada, Spain.
   [Petrova, Dafina; Ubago-Guisado, Esther; Perez-Gomez, Beatriz; Sanchez, Maria Jose] CIBER Epidemiol & Publ Hlth, Madrid, Spain.
   [Garcia-Retamero, Rocio; Catena, Andres; Caparros-Gonzalez, Rafael A.] Univ Granada, Granada, Spain.
   [Perez-Gomez, Beatriz] Hlth Inst Carlos III, Natl Ctr Epidemiol, Madrid, Spain.
   [Redondo-Sanchez, Daniel] Univ Granada, Dept Med Prevent & Salud Publ, Granada, Spain.
   [Ubago-Guisado, Esther] Univ Granada, Fac Sport Sci, Dept Phys Educ & Sports, Camino Alfacar 21, Granada 18071, Spain.
C3 Instituto de Investigacion Biosanitaria IBS Granada; Escuela Andaluza de
   Salud Publica; CIBER - Centro de Investigacion Biomedica en Red;
   CIBERESP; University of Granada; University of Granada; University of
   Granada
RP Ubago-Guisado, E (corresponding author), Univ Granada, Fac Sport Sci, Dept Phys Educ & Sports, Camino Alfacar 21, Granada 18071, Spain.
EM dafina.petrova@gmail.com; estherug@ugr.es; rretamer@ugr.es;
   daniel.redondo.easp@juntadeandalucia.es; bperez@isciii.es;
   acatena@ugr.es; rcg477@ugr.es;
   mariajose.sanchez.easp@juntadeandalucia.es
RI Martinez, Andres/KBC-9454-2024; Petrova, Dafina/AAH-8970-2019;
   Garcia-Retamero, Rocio/J-7040-2014; Perez-Gomez, Beatriz/C-4715-2012;
   Martín-Sánchez, Marta/E-5831-2018; Ubago Guisado, Esther/R-4025-2019;
   Redondo-Sanchez, Daniel/AEG-2668-2022; Caparros Gonzalez, Rafael
   Arcangel/P-1519-2015
OI Redondo-Sanchez, Daniel/0000-0001-9986-915X; Petrova,
   Dafina/0000-0002-0346-6776; Caparros Gonzalez, Rafael
   Arcangel/0000-0002-0565-1123
FU Juan de la Cierva Fellowship from the Ministry of Science and the
   National Research Agency of Spain (MCIN/AEI); Programa Operativo Fondo
   Social Europeo de Andalucia; Junta de Andalucia [DOC_01618]
FX D.P. is supported by a Juan de la Cierva Fellowship from the Ministry of
   Science and the National Research Agency of Spain (MCIN/AEI,
   JC2019-039691-I,http://doi.org/10.13039/501100011033, accessed October
   4, 2021). E.U.-G. is supported by the Programa Operativo Fondo Social
   Europeo de Andalucia (2014-2020) and Junta de Andalucia (reference
   DOC_01618).
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NR 39
TC 7
Z9 8
U1 5
U2 13
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0162-220X
EI 1538-9804
J9 CANCER NURS
JI Cancer Nurs.
PD JUL-AUG
PY 2024
VL 47
IS 4
BP 290
EP 298
DI 10.1097/NCC.0000000000001216
EA MAR 2023
PG 9
WC Oncology; Nursing
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Oncology; Nursing
GA WA4Q5
UT WOS:001153181500001
PM 36920171
DA 2025-06-11
ER

PT J
AU Lee, LJ
   Shamburek, R
   Son, H
   Wallen, GR
   Cox, R
   Flynn, S
   Yang, L
   Bevans, M
   Wehrlen, L
   Ross, A
AF Lee, Lena J.
   Shamburek, Robert
   Son, Hyojin
   Wallen, Gwenyth R.
   Cox, Robert
   Flynn, Sharon
   Yang, Li
   Bevans, Margaret
   Wehrlen, Leslie
   Ross, Alyson
TI Effects of a yoga-based stress reduction intervention on stress,
   psychological outcomes and cardiometabolic biomarkers in cancer
   caregivers: A randomized controlled trial
SO PLOS ONE
LA English
DT Article
ID INSULIN-RESISTANCE; FAMILY CAREGIVERS; CARDIOVASCULAR-DISEASE; PARTICLE
   NUMBER; RISK; BURDEN; SIZE; TRANSPLANTATION; INTENSITY; BEHAVIORS
AB Caregiving stress is a risk factor for cardiometabolic disease. Therefore, integrating cardiometabolic biomarkers into caregiving research provides a more comprehensive assessment of an individual's health and response to an intervention. The objective of this study was to examine the effects of a yoga-based stress reduction intervention on stress, psychological outcomes, and cardiometabolic biomarkers in cancer caregivers. This prospective randomized controlled trial enrolled family caregivers of adult patients who underwent an allogeneic HSCT at the National Institutes of Health (NIH) Clinical Center. All subjects received usual care education. Participants in the intervention group received an Iyengar yoga intervention self-administered over six weeks using an audio recording file. The primary outcome was perceived stress (measured using the NIH toolbox Perceived Stress). The secondary outcomes were psychological factors (depression and anxiety measured using PROMIS (R) Depression and Anxiety), and cardiometabolic biomarkers measured by nuclear magnetic resonance spectroscopy. A total of 50 family caregivers (mean [SD] age, 44.9 [15.2] years; 42 [84.0%] women) were randomized, 25 to the intervention group and 25 to the control group. No group differences were noted in stress, depression, and anxiety. Significant interaction effects between group and time were found in large TRL-P (F(1,43) = 10.16, p = 0.003) and LP-IR (F(1,42) = 4.28, p = 0.045). Post-hoc analyses revealed that the levels of large TRL-P (mean difference = 1.68, CI = [0.86, 2.51], p< .001) and LP-IR (mean difference = 5.67, CI = [1.15, 10.18], p = 0.015) significantly increased over time in the control group but while remained stable in the intervention group (mean difference = -0.15, CI = [-0.96, 0.66], p = 0.718; mean difference = -0.81, CI = [-5.22, 3.61], p = 0.714, respectively). Even when perceptions of psychological distress remain unchanged, incorporating gentle yoga poses and breathing exercises may reduce the risk of cardiometabolic disease in caregivers by inhibiting the development of insulin resistance. Standard lipids of cardiometabolic risk do not appear to be robust enough to detect short-term early changes of cardiometabolic risk in caregivers.
C1 [Lee, Lena J.; Son, Hyojin; Wallen, Gwenyth R.; Cox, Robert; Flynn, Sharon; Yang, Li; Ross, Alyson] NIH, Translat Biobehav & Hlth Dispar Branch, Clin Ctr, Bldg 10, Bethesda, MD 20892 USA.
   [Shamburek, Robert; Bevans, Margaret] NHLBI, NIH, Bldg 10, Bethesda, MD 20892 USA.
   [Wehrlen, Leslie] NIH, Off Res Support & Compliance, Clin Ctr, Bldg 10, Bethesda, MD 20892 USA.
C3 National Institutes of Health (NIH) - USA; NIH Clinical Center (CC);
   National Institutes of Health (NIH) - USA; NIH National Heart Lung &
   Blood Institute (NHLBI); National Institutes of Health (NIH) - USA; NIH
   Clinical Center (CC)
RP Lee, LJ (corresponding author), NIH, Translat Biobehav & Hlth Dispar Branch, Clin Ctr, Bldg 10, Bethesda, MD 20892 USA.
EM jumin.park@nih.gov
RI Wallen, Gwenyth/I-4750-2017; Yang, Li/KMG-3813-2024; Son,
   Elisa/LQK-0054-2024; Lee, Lena/ADJ-6635-2022
OI Son, Elisa H./0000-0002-3988-7492; Wehrlen, Leslie/0000-0002-7909-0293;
   Lee, Lena/0000-0002-2086-993X; Yang, Li/0000-0002-4513-872X
FU Intramural Research Program at the National Institutes of Health,
   Clinical Center [02257853]; NIH Clinical Center
FX This research was supported by the Intramural Research Program at the
   National Institutes of Health, Clinical Center (grant number
   NCT#02257853). All authors from the NIH Clinical Center received support
   for this study.
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NR 49
TC 9
Z9 10
U1 6
U2 20
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD NOV 10
PY 2022
VL 17
IS 11
AR e0277009
DI 10.1371/journal.pone.0277009
PG 14
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 8O8RH
UT WOS:000926098800043
PM 36355827
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Abu-Zaid, A
   Alzayed, MM
   Albahrani, SJ
   Almaqhawi, A
   Al Shaikh, MA
   Baradwan, S
   Almudiheem, NA
   Abuzaid, M
   Adly, HM
   Saleh, SAK
   Alomar, O
AF Abu-Zaid, Ahmed
   Alzayed, Mooza M.
   Albahrani, Suha Jafar
   Almaqhawi, Abdullah
   Al Shaikh, Mona Ahmed
   Baradwan, Saeed
   Almudiheem, Nawaf Abdulaziz
   Abuzaid, Mohammed
   Adly, Heba M.
   Saleh, Saleh A. K.
   Alomar, Osama
TI Does Magnesium Affect Sex Hormones and Cardiometabolic Risk Factors in
   Patients with PCOS? Findings from a Systematic Review and Meta-Analysis
SO MEDICINA-LITHUANIA
LA English
DT Review
DE magnesium; cardiometabolic risk factors; sex hormones; polycystic
   ovarian syndrome
ID POLYCYSTIC-OVARY-SYNDROME; INSULIN-RESISTANCE; METABOLIC SYNDROME;
   OXIDATIVE STRESS; OBESE WOMEN; ASSOCIATION; SUPPLEMENTATION;
   INFLAMMATION; OVERWEIGHT; METFORMIN
AB Background and Objectives: Polycystic ovary syndrome (PCOS) is a common endocrine disorder associated with various cardiometabolic risk factors, including insulin resistance, dyslipidemia, hypertension, and obesity, which contribute to an increased risk of cardiovascular diseases. This inaugural systematic review and meta-analysis of randomized controlled trials (RCTs) evaluated the impact of magnesium supplementation on various cardiometabolic risk factors and hormonal parameters in patients with polycystic ovary syndrome (PCOS). Materials and Methods: We systematically searched the MEDLINE, Web of Science, Scopus, and Cochrane databases until 30 March 2024 for studies comparing magnesium supplementation to control in improving cardiometabolic and hormonal factors in PCOS patients. Endpoints were summarized as mean differences (MD) and 95% confidence intervals (CIs) in a random-effects model. Results: The primary search yielded 176 studies. After screening, six studies met our inclusion criteria. Our meta-analysis showed no significant effects of magnesium supplementation on cardiometabolic risk factors and hormonal parameters in patients with PCOS. Conclusions: Magnesium supplementation does not appear to influence the cardiometabolic and hormonal factors in PCOS patients. Further rigorous RCTs are needed to strengthen the evidence and support comprehensive analysis in this area. PROSPERO database (CRD42024526110).
C1 [Abu-Zaid, Ahmed] Alfaisal Univ, Dept Biochem & Mol Med, Riyadh 11533, Saudi Arabia.
   [Alzayed, Mooza M.] Arabian Gulf Univ, Coll Med & Med Sci, Manama 329, Bahrain.
   [Albahrani, Suha Jafar; Almaqhawi, Abdullah] King Faisal Univ, Coll Med, Dept Family & Community Med, Al Hufuf 31982, Saudi Arabia.
   [Al Shaikh, Mona Ahmed] Eastern Hlth Cluster, Dept Family Med, Dammam 32253, Saudi Arabia.
   [Baradwan, Saeed] King Faisal Specialist Hosp & Res Ctr, Dept Obstet & Gynecol, Jeddah 23433, Saudi Arabia.
   [Almudiheem, Nawaf Abdulaziz] Al Imam Muhammad Ibn Saud Islamic Univ, Coll Med, Riyadh 13317, Saudi Arabia.
   [Abuzaid, Mohammed] Al Birk Gen Hosp, Dept Obstet & Gynecol, Al Birk 63525, Saudi Arabia.
   [Adly, Heba M.] Umm Al Qura Univ, Fac Med, Dept Community Med & Pilgrims Healthcare, Mecca 24382, Saudi Arabia.
   [Saleh, Saleh A. K.] Umm Al Qura Univ, Fac Med, Dept Biochem, Mecca 24382, Saudi Arabia.
   [Alomar, Osama] King Faisal Specialist Hosp & Res Ctr, Dept Obstet & Gynecol, Riyadh 12713, Saudi Arabia.
C3 Arabian Gulf University; King Faisal University; King Faisal Specialist
   Hospital & Research Center; Imam Mohammad Ibn Saud Islamic University
   (IMSIU); Umm Al-Qura University; Umm Al-Qura University; King Faisal
   Specialist Hospital & Research Center
RP Abu-Zaid, A (corresponding author), Alfaisal Univ, Dept Biochem & Mol Med, Riyadh 11533, Saudi Arabia.
EM amabuzaid@alfaisal.edu
RI Abu El-Magd, Sherif/AAN-4838-2021; Baradwan, Saeed/I-3387-2019; Saleh,
   Saleh/S-6837-2019; Almaqhawi, Abdullah/AAD-7029-2021; Adly, Prof
   Heba/IQU-8083-2023
OI Adly, Prof Heba/0000-0002-9222-9149
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NR 65
TC 0
Z9 0
U1 0
U2 0
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
SN 1010-660X
EI 1648-9144
J9 MEDICINA-LITHUANIA
JI Med. Lith.
PD FEB
PY 2025
VL 61
IS 2
AR 280
DI 10.3390/medicina61020280
PG 16
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA Y2A9Z
UT WOS:001430231300001
PM 40005397
OA gold
DA 2025-06-11
ER

PT J
AU Gross, AC
   Kaizer, AM
   Ryder, JR
   Fox, CK
   Rudser, KD
   Dengel, DR
   Kelly, AS
AF Gross, Amy C.
   Kaizer, Alexander M.
   Ryder, Justin R.
   Fox, Claudia K.
   Rudser, Kyle D.
   Dengel, Donald R.
   Kelly, Aaron S.
TI Relationships of Anxiety and Depression with Cardiovascular Health in
   Youth with Normal Weight to Severe Obesity
SO JOURNAL OF PEDIATRICS
LA English
DT Article
ID SCIENTIFIC STATEMENT; RISK-FACTORS; ADOLESCENTS; CHILDREN; DISEASE;
   DISORDERS; HYPERTENSION; CHILDHOOD
AB Objective To evaluate the relationships of depression and anxiety symptoms with cardiovascular disease (CVD) risk factors and measures of vascular health in youth.
   Study design Participants (n = 202) were 8- to 18-year-olds from a cross-sectional study evaluating cardiovascular health across a wide range of body mass index values (normal weight to severe obesity). CVD risk measurement included blood pressure, fasting lipids, glucose, insulin, carotid artery intima-media thickness, compliance and distensibility, brachial artery flow-mediated dilation, carotid-radial artery pulse wave velocity, body fat percentage, and a metabolic syndrome cluster score. Anxiety and depression symptoms were self-reported on the Screen for Child Anxiety Related Disorders and Center for Epidemiological Studies Depression Scale for Children. Two sets of adjustment variables were used in evaluation of differences between those with and without anxiety or depression symptomatology for the CVD risk factor and vascular outcomes. The first set included adjustment for Tanner stage, sex, and race; the second was additionally adjusted for percent body fat.
   Results Anxiety was not significantly associated with CVD risk factors or vascular health in either model. Depression was associated with high-density lipoprotein cholesterol, triglycerides, and metabolic syndrome cluster score; these relationships were attenuated when accounting for percent body fat.
   Conclusions When accounting for body fat, we found no clear relationship of self-reported depression or anxiety symptoms with CVD risk factors or vascular health in youth.
C1 [Gross, Amy C.; Ryder, Justin R.; Fox, Claudia K.; Dengel, Donald R.; Kelly, Aaron S.] Univ Minnesota, Sch Med, Dept Pediat, Minneapolis, MN 55455 USA.
   [Gross, Amy C.; Ryder, Justin R.; Fox, Claudia K.; Rudser, Kyle D.; Dengel, Donald R.; Kelly, Aaron S.] Univ Minnesota, Ctr Pediat Obes Med, Minneapolis, MN 55455 USA.
   [Kaizer, Alexander M.; Rudser, Kyle D.] Univ Minnesota, Div Biostat, Minneapolis, MN 55455 USA.
   [Dengel, Donald R.] Univ Minnesota, Sch Kinesiol, Minneapolis, MN 55455 USA.
   [Kelly, Aaron S.] Univ Minnesota, Sch Med, Dept Med, Minneapolis, MN 55455 USA.
C3 University of Minnesota System; University of Minnesota Twin Cities;
   University of Minnesota System; University of Minnesota Twin Cities;
   University of Minnesota System; University of Minnesota Twin Cities;
   University of Minnesota System; University of Minnesota Twin Cities;
   University of Minnesota System; University of Minnesota Twin Cities
RP Gross, AC (corresponding author), 2512 S 7th St 3rd Floor, Minneapolis, MN 55454 USA.
EM acgross@umn.edu
RI Kaizer, Alexander/AFA-2522-2022
OI Dengel, Donald/0000-0001-9049-7548; Ryder, Justin/0000-0002-7506-9497;
   Gross, Amy/0000-0003-2809-8460
FU National Heart, Lung, and Blood Institute/NIH [R01HL110957]; National
   Center for Advancing Translational Sciences/NIH [UL1TR000114]; National
   Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)/NIH NORC
   [P30 DK050456]; Astra Zeneca Pharmaceuticals; Novo Nordisk
FX Funded by the National Heart, Lung, and Blood Institute/NIH
   (R01HL110957), the National Center for Advancing Translational
   Sciences/NIH (UL1TR000114), and the National Institute of Diabetes and
   Digestive and Kidney Diseases (NIDDK)/NIH NORC (P30 DK050456). The
   content is solely the responsibility of the authors and does not
   necessarily represent the official views of the National Institutes of
   Health. A.K. receives research support (drug/placebo) from Astra Zeneca
   Pharmaceuticals and serves as a consultant for Novo Nordisk, Orexigen,
   and Vivus Pharmaceuticals but does not accept personal or professional
   income for these activities. C.F. receives research support from Novo
   Nordisk. The other authors declare no conflicts of interest.
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NR 26
TC 23
Z9 23
U1 0
U2 16
PU MOSBY-ELSEVIER
PI NEW YORK
PA 360 PARK AVENUE SOUTH, NEW YORK, NY 10010-1710 USA
SN 0022-3476
EI 1097-6833
J9 J PEDIATR-US
JI J. Pediatr.
PD AUG
PY 2018
VL 199
BP 85
EP 91
DI 10.1016/j.jpeds.2018.03.059
PG 7
WC Pediatrics
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Pediatrics
GA GN9CG
UT WOS:000439478200018
PM 29754863
OA Green Accepted, Bronze
DA 2025-06-11
ER

PT J
AU Hsu, YW
   Chang, CP
AF Hsu, Ya-Wen
   Chang, Chun-Ping
TI Stress of life events and anxiety as mediators of the association
   between insomnia and triglycerides in college students
SO JOURNAL OF AMERICAN COLLEGE HEALTH
LA English
DT Article
DE Anxiety; insomnia; mediation; metabolic; stress
ID BODY-MASS INDEX; SLEEP DURATION; METABOLIC SYNDROME; INSULIN-SECRETION;
   CHOLESTEROL RATIO; HDL-CHOLESTEROL; RISK; DEPRESSION; OBESITY;
   RESISTANCE
AB Purpose This study examined interrelationships among insomnia, stress, anxiety, and metabolic risk factors.Methods: A total of 124 college students were included in the analysis (age = 21 +/- 1 years). Insomnia, stress of life events, and anxiety were assessed using self-reported questionnaires. Fasting blood samples were assayed for glucose, insulin, total cholesterol, triglycerides, high-density lipoprotein cholesterol (HDL-cholesterol), and low-density lipoprotein cholesterol (LDL-cholesterol).Results: Insomnia was positively associated with stress of life events (beta = 0.28,p < .001) and anxiety (beta = 0.46,p < .001). Insomnia was related to elevated fasting insulin (beta = 0.12,p = .04) and triglyceride level (beta = 1.85,p < .001). An inverse association was found between insomnia and HDL-cholesterol (beta = -0.45,p = .03). Sobel's test for mediation showed that stress of life events (p = .020) and anxiety (p = .013) mediated the relationship between insomnia and hypertriglyceridemia.Conclusions: Reducing stress and anxiety among college students with insomnia may influence subsequent cardiovascular health.
C1 [Hsu, Ya-Wen; Chang, Chun-Ping] Chia Nan Univ Pharm & Sci, Dept Hosp & Hlth Care Adm, 60,Sec 1,Erren Rd, Tainan 71710, Taiwan.
C3 Chia Nan University of Pharmacy & Science
RP Hsu, YW (corresponding author), Chia Nan Univ Pharm & Sci, Dept Hosp & Hlth Care Adm, 60,Sec 1,Erren Rd, Tainan 71710, Taiwan.
EM janiceywhsu@gmail.com
RI Chang, Chun-Ping/KIJ-1434-2024
FU Ministry of Science and Technology [NSC 102-2410-H-041-009]
FX This study was supported by Grant from Ministry of Science and
   Technology (NSC 102-2410-H-041-009).
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NR 50
TC 14
Z9 14
U1 2
U2 7
PU ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
SN 0744-8481
EI 1940-3208
J9 J AM COLL HEALTH
JI J. Am. Coll. Health
PD JUN 22
PY 2022
VL 70
IS 5
BP 1396
EP 1402
DI 10.1080/07448481.2020.1799805
EA JUL 2020
PG 7
WC Education & Educational Research; Public, Environmental & Occupational
   Health
WE Social Science Citation Index (SSCI)
SC Education & Educational Research; Public, Environmental & Occupational
   Health
GA 2U3TL
UT WOS:000559559800001
PM 32790499
DA 2025-06-11
ER

PT J
AU Wentzel, A
   Naudé, D
   von Känel, R
AF Wentzel, Annemarie
   Naude, Dewald
   von Kanel, Roland
TI Acute mental stress-induced alpha or beta-adrenergic reactivity patterns
   linked to unique cardiometabolic risk profiles
SO SCIENTIFIC REPORTS
LA English
DT Article
DE Acute mental stress; alpha-adrenergic response; beta-adrenergic
   response; Cardiometabolic risk
ID CARDIOVASCULAR REACTIVITY; METABOLIC SYNDROME; HEART; PRESSURE; AFRICANS
AB Cardiometabolic risk may differ based on a stress-induced alpha(alpha)-adrenergic response versus a predominant beta(beta)-adrenergic response. Whether these responses might serve as significant markers of distinct cardiometabolic risk profiles based on hemodynamic reactivity remain unknown. We (1) characterized predominant alpha-and beta-adrenergic hemodynamic response patterns to acute mental stress; and (2) determined the cardiometabolic risk profile within predominant alpha-or beta-adrenergic responders, irrespective of age, sex, or ethnicity. We included 117 South African teachers (aged 20-65 years) and administered an acute mental stress task (Color-Word-Conflict test) for one-minute. Participants' hemodynamic response profiles were characterized as predominant alpha-adrenergic (decreases in cardiac output (CO) and Windkessel arterial compliance (C-wk) (lowest quartile)) (n = 48) and beta-adrenergic (increases in CO, C-wk (highest quartile)) responses (n = 69) via Finometer beat-to-beat hemodynamic monitoring. Ambulatory-BP was measured and the number of 24 H-ischemic events determined by ECG. Cardiometabolic markers were analyzed using fasting blood samples, and abnormal glucose tolerance (Abnl-GT), combining prediabetes and diabetes, was defined as glycated hemoglobin (HbA1c) >= 5.7% and/or fasting glucose > 100 mg/dL and/or diabetes medication usage. Predominant alpha-adrenergic responders presented with an overall poorer cardiometabolic profile, with higher levels of HbA1c, insulin, greater insulin resistance and higher total cholesterol and lower HDL-cholesterol. Adjusted analyses indicated that a predominant alpha-adrenergic profile had higher odds of central obesity (P = 0.031), low HDL-cholesterol (P = 0.042), 24-H-hypertension (P < 0.001), cardiac stress (P = 0.025), ischemic events (P = 0.048) and medium-to-high 10-year stroke probability (P < 0.001), compared to beta-adrenergic responders. In the beta-adrenergic responders, higher odds for ischemic events, stroke probability and Abnl-GT were found (all P <= 0.022), compared to alpha-adrenergic responders. Independent of age, sex or ethnicity, the risk profile identified in predominant alpha-adrenergic responders mainly involved the effects of a high-pressure system, cardiac stress, and ischemia. Whereas in predominant beta-adrenergic responders, the risk profile pointed to a more metabolic and hyperperfusion injury-related cardiometabolic risk.
C1 [Wentzel, Annemarie; Naude, Dewald] North West Univ, Hypertens Afr Res Team HART, Private Bag X6001, ZA-2520 Potchefstroom, South Africa.
   [Wentzel, Annemarie] North West Univ, South African Med Res Council, Unit Hypertens & Cardiovasc Dis, Potchefstroom, South Africa.
   [von Kanel, Roland] Univ Hosp Zurich, Dept Consultat Liaison Psychiat & Psychosomat Med, Zurich, Switzerland.
C3 North West University - South Africa; South African Medical Research
   Council; North West University - South Africa; University of Zurich;
   University Zurich Hospital
RP Wentzel, A (corresponding author), North West Univ, Hypertens Afr Res Team HART, Private Bag X6001, ZA-2520 Potchefstroom, South Africa.; Wentzel, A (corresponding author), North West Univ, South African Med Res Council, Unit Hypertens & Cardiovasc Dis, Potchefstroom, South Africa.
EM Annemarie.Wentzel@nwu.ac.za
RI Wentzel, Annemarie/IUO-0720-2023; von Kanel, Roland/B-1811-2019
OI von Kanel, Roland/0000-0002-8929-5129; Naude, Dewald/0000-0001-9657-0953
FU North-West University; Hypertension in Africa Research Team (HART),
   South African National Research Foundation (NRF); South African Medical
   Research Council (SA-MRC); Metabolic Syndrome institute, France;
   North-West Department of Education
FX The authors wish to acknowledge the participants of the SABPA study,
   research staff and postgraduate students affiliated with the
   Hypertension in Africa Research Team (HART), South African National
   Research Foundation (NRF) and South African Medical Research Council
   (SA-MRC) support. The SABPA study was also supported by the Metabolic
   Syndrome institute, France, North-West University, and the North-West
   Department of Education. The researchers would like to acknowledge Prof
   Wayne Smith for his keen observations and objective, informal review of
   the methodology in the early phases of this project, which ultimately
   contributed to the validity and integrity of the data reported.
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NR 43
TC 0
Z9 0
U1 0
U2 0
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD MAR 13
PY 2025
VL 15
IS 1
AR 8668
DI 10.1038/s41598-025-92961-2
PG 13
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 0DQ7F
UT WOS:001444883200005
PM 40082568
OA gold
DA 2025-06-11
ER

PT J
AU Holmes, ME
   Pivarnik, J
   Pfeiffer, K
   Maier, KS
   Eisenmann, JC
   Ewing, M
AF Holmes, Megan E.
   Pivarnik, Jim
   Pfeiffer, Karin
   Maier, Kimberly S.
   Eisenmann, Joey C.
   Ewing, Martha
TI The Stress-Metabolic Syndrome Relationship in Adolescents: An
   Examination of the Moderating Potential of Physical Activity
SO JOURNAL OF PHYSICAL ACTIVITY & HEALTH
LA English
DT Article
DE mental health; obesity; youth
ID RELATIVE WEIGHT; UNITED-STATES; OBESITY; VALIDATION; ADIPOSITY;
   CHILDREN; EXERCISE; FITNESS; SCORE; LIFE
AB Background: The role of psychosocial stress in the development of obesity and metabolic syndrome is receiving increased attention and has led to examination of whether physical activity may moderate the stress-metabolic syndrome relationship. The current study examined relationships among physical activity, stress, and metabolic syndrome in adolescents. Methods: Participants (N = 126; 57 girls, 69 boys) were assessed for anthropometry, psychosocial stress, physical activity, and metabolic syndrome variables; t tests were used to examine sex differences, and regression analysis was used to assess relationships among variables controlling for sex and maturity status. Results: Mean body mass index approached the 75th percentile for both sexes. Typical sex differences were observed for systolic blood pressure, time spent in moderate and vigorous physical activity, and perceived stress. Although stress was not associated with MetS (beta=-.001, P=.82), a modest, positive relationship was observed with BMI (beta=.20, P=.04). Conclusions: Strong relationships between physical activity and stress with MetS or BMI were not found in this sample. Results may be partially explained by overall good physical health status of the participants. Additional research in groups exhibiting varying degrees of health is needed.
C1 [Holmes, Megan E.] Mississippi State Univ, Dept Kinesiol, Mississippi State, MS 39762 USA.
   [Pivarnik, Jim; Pfeiffer, Karin; Eisenmann, Joey C.; Ewing, Martha] Michigan State Univ, Dept Kinesiol, E Lansing, MI 48824 USA.
   [Maier, Kimberly S.] Michigan State Univ, Dept Measurement & Quantitat Methods, E Lansing, MI 48824 USA.
C3 Mississippi State University; Michigan State University; Michigan State
   University
RP Holmes, ME (corresponding author), Mississippi State Univ, Dept Kinesiol, Mississippi State, MS 39762 USA.
EM mholmes@colled.msstate.edu
RI Pfeiffer, Karin/D-5252-2018; Holmes, Megan/AAX-6919-2021
OI Holmes, Megan/0000-0003-1716-6122
FU Blue Cross Blue Shield Foundation of Michigan Student Award Program; MSU
   College of Education student research grant
FX The authors extend special thanks the physical education teacher of the
   participating school for her support of the project. This study was
   partially funded by grants from the Blue Cross Blue Shield Foundation of
   Michigan Student Award Program and MSU College of Education student
   research grant awarded to MEH.
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NR 44
TC 5
Z9 6
U1 0
U2 6
PU HUMAN KINETICS PUBL INC
PI CHAMPAIGN
PA 1607 N MARKET ST, PO BOX 5076, CHAMPAIGN, IL 61820-2200 USA
SN 1543-3080
EI 1543-5474
J9 J PHYS ACT HEALTH
JI J. Phys. Act. Health
PD OCT
PY 2016
VL 13
IS 10
BP 1088
EP 1093
DI 10.1123/jpah.2016-0041
PG 6
WC Public, Environmental & Occupational Health
WE Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA EB8ID
UT WOS:000387633800009
PM 27254850
DA 2025-06-11
ER

PT J
AU Dodd, S
   Malhi, GS
   Tiller, J
   Schweitzer, I
   Hickie, I
   Khoo, JP
   Bassett, DL
   Lyndon, B
   Mitchell, PB
   Parker, G
   Fitzgerald, PB
   Udina, M
   Singh, A
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   Giorlando, F
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   Davey, CG
   Theodoros, M
   Berk, M
AF Dodd, Seetal
   Malhi, Gin S.
   Tiller, John
   Schweitzer, Isaac
   Hickie, Ian
   Khoo, Jon Paul
   Bassett, Darryl L.
   Lyndon, Bill
   Mitchell, Philip B.
   Parker, Gordon
   Fitzgerald, Paul B.
   Udina, Marc
   Singh, Ajeet
   Moylan, Steven
   Giorlando, Francesco
   Doughty, Carolyn
   Davey, Christopher G.
   Theodoros, Michael
   Berk, Michael
TI A consensus statement for safety monitoring guidelines of treatments for
   major depressive disorder
SO AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
LA English
DT Article
ID SEROTONIN REUPTAKE INHIBITORS; VITAMIN-D INSUFFICIENCY;
   EPSTEIN-BARR-VIRUS; DRUG-INTERACTIONS; MENTAL-HEALTH; INAPPROPRIATE
   SECRETION; PSYCHIATRIC-DISORDERS; SEVERE HYPONATREMIA; METABOLIC
   SYNDROME; ANXIETY DISORDERS
AB Objective: This paper aims to present an overview of screening and safety considerations for the treatment of clinical depressive disorders and make recommendations for safety monitoring.
   Method: Data were sourced by a literature search using MEDLINE and a manual search of scientific journals to identify relevant articles. Draft guidelines were prepared and serially revised in an iterative manner until all co-authors gave final approval of content.
   Results: Screening and monitoring can detect medical causes of depression. Specific adverse effects associated with antidepressant treatments may be reduced or identified earlier by baseline screening and agent-specific monitoring after commencing treatment.
   Conclusion: The adoption of safety monitoring guidelines when treating clinical depression is likely to improve overall physical health status and treatment outcome. It is important to implement these guidelines in the routine management of clinical depression.
C1 [Dodd, Seetal; Moylan, Steven; Berk, Michael] Deakin Univ, Geelong, Vic 3217, Australia.
   [Tiller, John; Schweitzer, Isaac; Singh, Ajeet; Giorlando, Francesco; Berk, Michael] Univ Melbourne, Dept Psychiat, Parkville, Vic 3052, Australia.
   [Malhi, Gin S.; Lyndon, Bill] Univ Sydney, Sydney Med Sch, Discipline Psychiat, Sydney, NSW 2006, Australia.
   [Hickie, Ian] Univ Sydney, Brain & Mind Res Inst, Sydney, NSW 2006, Australia.
   [Khoo, Jon Paul] Toowong Specialist Clin, Brisbane, Qld, Australia.
   [Bassett, Darryl L.] Univ W Australia, Sch Psychol & Clin Neurosci, Perth, WA, Australia.
   [Bassett, Darryl L.] Univ Notre Dame, Sch Med, Fremantle, WA, Australia.
   [Mitchell, Philip B.] Univ New S Wales, Sch Psychiat, Kensington, NSW 2033, Australia.
   [Parker, Gordon] Black Dog Inst, Sydney, NSW, Australia.
   [Fitzgerald, Paul B.] Alfred & Monash Univ, Sch Psychol & Psychiat, Monash Alfred Psychiat Res Ctr, Melbourne, Vic, Australia.
   [Udina, Marc] Univ Barcelona, Bipolar Disorders Program, Inst Clin Neurosci, Hosp Clin,IDIBAPS,CIBERSAM, E-08007 Barcelona, Catalonia, Spain.
   [Doughty, Carolyn] Univ Otago, Child & Family Specialty Serv, Canterbury Dist Hlth Board, Christchurch, New Zealand.
   [Doughty, Carolyn] Univ Otago, Dept Publ Hlth & Gen Practice, Christchurch, New Zealand.
   [Davey, Christopher G.; Berk, Michael] Orygen Youth Hlth Res Ctr, Parkville, Vic, Australia.
   [Theodoros, Michael] New Farm Clin, Eating Disorders Program, Brisbane, Qld, Australia.
   [Berk, Michael] Mental Hlth Res Inst, Parkville, Vic, Australia.
C3 Deakin University; University of Melbourne; University of Sydney;
   University of Sydney; University of Western Australia; The University of
   Notre Dame Australia; University of New South Wales Sydney; Black Dog
   Institute; Monash University; University of Barcelona; Hospital Clinic
   de Barcelona; IDIBAPS; CIBER - Centro de Investigacion Biomedica en Red;
   CIBERSAM; University of Otago; University of Otago; Orygen, The National
   Centre of Excellence in Youth Mental Health; Florey Institute of
   Neuroscience & Mental Health
RP Dodd, S (corresponding author), Deakin Univ, Geelong, Vic 3217, Australia.
RI Berk, Michael/AGH-9427-2022; Berk, Michael/M-7891-2013; Malhi,
   Gin/Z-2418-2019; Fitzgerald, Paul/A-1225-2008; Hickie, Ian/K-8975-2015;
   Davey, Christopher/B-3517-2011
OI Mitchell, Philip/0000-0002-7954-5235; Udina, Marc/0000-0002-6750-9667;
   Berk, Michael/0000-0002-5554-6946; Malhi, Gin/0000-0002-4524-9091;
   Moylan, Steven/0000-0001-8901-6225; Fitzgerald,
   Paul/0000-0003-4217-8096; Hickie, Ian/0000-0001-8832-9895; Davey,
   Christopher/0000-0003-1431-3852; Khoo, Jon-Paul/0009-0006-1860-527X;
   Parker, Gordon/0000-0003-3424-5519; Dodd, Seetal/0000-0002-7918-4636
FU Servier Laboratories (Australia) Pty. Ltd.
FX This paper was completed under the auspices of the Australasian Society
   for Bipolar and Depressive Disorders. It was supported by an
   unrestricted grant from Servier Laboratories (Australia) Pty. Ltd. 8
   Cato Street, Hawthorn VIC 3122, Australia to M.B and S.D. However, at no
   point in the process of planning, synthesis and writing was there any
   input or involvement from Servier. The authors alone are responsible for
   the content and writing of the paper.
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NR 173
TC 37
Z9 39
U1 0
U2 10
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0004-8674
EI 1440-1614
J9 AUST NZ J PSYCHIAT
JI Aust. N. Z. J. Psych.
PD SEP
PY 2011
VL 45
IS 9
BP 712
EP 725
DI 10.3109/00048674.2011.595686
PG 14
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA 818TQ
UT WOS:000294778900020
PM 21888608
OA Green Published
DA 2025-06-11
ER

PT J
AU Rhee, SJ
   Kim, EY
   Kim, SH
   Lee, HJ
   Kim, B
   Ha, K
   Yoon, DH
   Ahn, YM
AF Rhee, Sang Jin
   Kim, Eun Young
   Kim, Se Hyun
   Lee, Hyun Jeong
   Kim, Bora
   Ha, Kyooseob
   Yoon, Dae Hyun
   Ahn, Yong Min
TI Subjective depressive symptoms and metabolic syndrome among the general
   population
SO PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
LA English
DT Article
DE Depression; Depressive symptoms; Gender; Lipid; Metabolic syndrome
ID MAJOR DEPRESSION; INSULIN-RESISTANCE; YOUNG-ADULTS; ASSOCIATION;
   ANXIETY; RISK; HEALTH; WOMEN; INFLAMMATION; METAANALYSIS
AB Objective: The evidence of the association between depression and metabolic syndrome is increasing, but the existence of sex differences in this association remains controversial. The aim of this study was to investigate the association between subjective depressive symptoms and metabolic syndrome and each of its components by sex in the Korean population.
   Methods: The study sample comprised 15,073 men and 15,034 women who underwent routine health examinations. They completed the Beck Depression Inventory for depressive symptoms, and medical examinations provided data regarding metabolic syndrome. Adjustments for age, marriage, cigarette smoking, alcohol use, exercise, education, cancer, stroke, angina, and thyroid disease were performed. The association between depressive symptoms and metabolic syndrome and each of its components was analyzed by multiple logistic regression.
   Results: In women, depressive symptoms were associated with metabolic syndrome (OR = 1.35, 95% CI = 1.11-1.64, p = 0.002) and the high-density lipoprotein cholesterol component (OR = 1.26, 95% CI = 1.09-1.46, p = 0.002) of metabolic syndrome. There was also an association between the severity of depressive symptoms and metabolic syndrome in women (OR = 1.046, 95% CI = 1.002-1.091, p = 0.039). In men, depressive symptoms were inversely associated with the hypertension component of metabolic syndrome (OR = 0.73, 95% CI = 0.58-0.91, p = 0.005).
   Conclusions: Subjective depressive symptoms were associated with metabolic syndrome only in women. Further research should consider sex differences and dyslipidemia. (C) 2014 Elsevier Inc. All rights reserved.
C1 [Rhee, Sang Jin; Kim, Eun Young; Lee, Hyun Jeong; Kim, Bora; Ahn, Yong Min] Seoul Natl Univ Hosp, Dept Psychiat, Seoul 110744, South Korea.
   [Kim, Se Hyun] Seoul Natl Univ, Med Res Inst, Inst Human Behav Med, Seoul 110744, South Korea.
   [Ha, Kyooseob; Ahn, Yong Min] Seoul Natl Univ, Coll Med, Inst Human Behav Med, Seoul 110744, South Korea.
   [Ha, Kyooseob] Seoul Natl Univ, Bundang Hosp, Dept Neuropsychiat, Mood Disorders Clin, Songnam 463707, Gyeonggi, South Korea.
   [Ha, Kyooseob] Seoul Natl Univ, Bundang Hosp, Dept Neuropsychiat, Affect Neurosci Lab, Songnam 463707, Gyeonggi, South Korea.
   [Yoon, Dae Hyun] Seoul Natl Univ Hosp, Healthcare Syst Gangnam Ctr, Dept Psychiat, Seoul 135984, South Korea.
C3 Seoul National University (SNU); Seoul National University Hospital;
   Seoul National University (SNU); Seoul National University (SNU); Seoul
   National University (SNU); Seoul National University (SNU); Seoul
   National University (SNU); Seoul National University Hospital
RP Yoon, DH (corresponding author), Seoul Natl Univ Hosp, Gangnam Hlth Promot Ctr, Dept Psychiat, 737 Yeoksam Dong, Seoul 135984, South Korea.
EM dhyoon@snuh.org; aym@snu.ac.kr
RI Kim, Byung-Hak/AAY-9891-2020; Yoon, Dae/C-4302-2013; Ha,
   Kyooseob/J-5698-2012; Kim, Kyung/F-3470-2010
OI Ha, Kyooseob/0000-0001-5035-2950; Kim, Bora/0000-0002-6333-9023
FU Korea Healthcare Technology R & D Project, Ministry of Health and
   Welfare, Republic of Korea [A121987]
FX This work was supported by grant A121987 from the Korea Healthcare
   Technology R & D Project, Ministry of Health and Welfare, Republic of
   Korea.
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NR 54
TC 31
Z9 37
U1 0
U2 25
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0278-5846
J9 PROG NEURO-PSYCHOPH
JI Prog. Neuro-Psychopharmacol. Biol. Psychiatry
PD OCT 3
PY 2014
VL 54
BP 223
EP 230
DI 10.1016/j.pnpbp.2014.06.006
PG 8
WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA AO2PN
UT WOS:000341167800028
PM 24975752
DA 2025-06-11
ER

PT J
AU Assadi, SN
AF Assadi, Seyedeh Negar
TI What are the effects of psychological stress and physical work on blood
   lipid profiles?
SO MEDICINE
LA English
DT Article
DE lipid disorder; physical activity; stress; work
ID CARDIOVASCULAR RISK-FACTORS; METABOLIC SYNDROME; PROSPECTIVE COHORT;
   SHIFT WORK; JOB STRESS; DISEASE; HEALTH; DYSLIPIDEMIA; HYPERTENSION;
   PREVALENCE
AB Blood lipids disorders are prevalent in the world. Some of their risk factors are modifiable such as mental and physical stress which existed in some places such as work environment.
   Objective of this study was to determine the effects of psychological and physical stress on the lipid profiles. It was a historical cohort study. The people who were employed as general worker were participated. The study was conducted with flexible interview for getting history, lipid profile examination, and a checklist including occupational and nonoccupational risk factors and using the health issues. According to the type of stress exposures, the study population was divided into 5 groups. Groups were followed for lipid profiles. These groups were exposed to psychological stress, physical stress or both of them; mild psychological stress (group 1), mild physical work without psychological stress (group 2), mild psychological stress and mild physical work (group 3), moderate physical work without psychological stress (group 4), and heavy physical work without psychological stress (group 5). Data were analyzed with SPSS 16. ANOVA, chi(2), and exact test were calculated with considering P<.05 as significant level. Relative risks were calculated with confidence interval 95%. The means of lipid profiles were in normal ranges. The relative risks for triglycerides more than 200mg/dL was 1.57 (1.02-2.42) and low density lipoprotein (LDL) more than 130mg/dL was 14.54 (3.54-59.65) in group 1. The relative risks for high density lipoprotein (HDL) less than 45mg/dL was 14.61 (8.31-25.68) in group 1 and 16.00 (8.30-30.83) in group 3. After multinomial logistic regression they had significant differences. Psychological stress was a risk factor for lipid disorders, and suitable physical activity was protective in this situation.
C1 [Assadi, Seyedeh Negar] Mashhad Univ Med Sci, Dept Occupat Hlth Engn, Sch Hlth, Social Determinants Hlth Res Ctr, Mashhad, Iran.
C3 Mashhad University of Medical Sciences
RP Assadi, SN (corresponding author), Mashhad Univ Med Sci, Dept Occupat Hlth Engn, Sch Hlth, Social Determinants Hlth Res Ctr, Mashhad, Iran.
EM assadin@mums.ac.ir
RI Assadi, Seyedeh Negar/C-6516-2019
OI Assadi, Seyedeh Negar/0000-0003-3781-2056
FU Mashhad University of Medical Sciences
FX The author appreciated the supports of Mashhad University of Medical
   Sciences. Author thanks a lot the honorable journal and the publisher.
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NR 40
TC 32
Z9 36
U1 1
U2 13
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0025-7974
EI 1536-5964
J9 MEDICINE
JI Medicine (Baltimore)
PD MAY
PY 2017
VL 96
IS 18
AR e6816
DI 10.1097/MD.0000000000006816
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA EU2FM
UT WOS:000400842700034
PM 28471984
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Farooqui, AA
   Farooqui, T
   Panza, F
   Frisardi, V
AF Farooqui, Akhlaq A.
   Farooqui, Tahira
   Panza, Francesco
   Frisardi, Vincenza
TI Metabolic syndrome as a risk factor for neurological disorders
SO CELLULAR AND MOLECULAR LIFE SCIENCES
LA English
DT Review
DE Metabolic syndrome; Insulin; Leptin; Insulin resistance; Inflammation;
   Oxidative stress; Hypertension; Stroke; Alzheimer's disease; Depression
ID PROTEIN-KINASE-B; CANNABINOID CB2 RECEPTOR; GLUCAGON-LIKE PEPTIDE-1;
   CORONARY-HEART-DISEASE; CENTRAL-NERVOUS-SYSTEM; C-REACTIVE PROTEIN;
   INSULIN-RESISTANCE; LIPID-PEROXIDATION; OXIDATIVE STRESS;
   ALZHEIMERS-DISEASE
AB The metabolic syndrome is a cluster of common pathologies: abdominal obesity linked to an excess of visceral fat, insulin resistance, dyslipidemia and hypertension. At the molecular level, metabolic syndrome is accompanied not only by dysregulation in the expression of adipokines (cytokines and chemokines), but also by alterations in levels of leptin, a peptide hormone released by white adipose tissue. These changes modulate immune response and inflammation that lead to alterations in the hypothalamic 'bodyweight/appetite/satiety set point,' resulting in the initiation and development of metabolic syndrome. Metabolic syndrome is a risk factor for neurological disorders such as stroke, depression and Alzheimer's disease. The molecular mechanism underlying the mirror relationship between metabolic syndrome and neurological disorders is not fully understood. However, it is becoming increasingly evident that all cellular and biochemical alterations observed in metabolic syndrome like impairment of endothelial cell function, abnormality in essential fatty acid metabolism and alterations in lipid mediators along with abnormal insulin/leptin signaling may represent a pathological bridge between metabolic syndrome and neurological disorders such as stroke, Alzheimer's disease and depression. The purpose of this review is not only to describe the involvement of brain in the pathogenesis of metabolic syndrome, but also to link the pathogenesis of metabolic syndrome with neurochemical changes in stroke, Alzheimer's disease and depression to a wider audience of neuroscientists with the hope that this discussion will initiate more studies on the relationship between metabolic syndrome and neurological disorders.
C1 [Farooqui, Akhlaq A.; Farooqui, Tahira] Ohio State Univ, Dept Mol & Cellular Biochem, Columbus, OH 43221 USA.
   [Panza, Francesco; Frisardi, Vincenza] IRCCS Casa Sollievo Sofferenza, Geriatr Unit, San Giovanni Rotondo, Italy.
   [Panza, Francesco; Frisardi, Vincenza] IRCCS Casa Sollievo Sofferenza, Gerontol Geriatr Res Lab, San Giovanni Rotondo, Italy.
C3 University System of Ohio; Ohio State University; IRCCS Casa Sollievo
   Della Sofferenza; IRCCS Casa Sollievo Della Sofferenza
RP Farooqui, AA (corresponding author), Ohio State Univ, Dept Mol & Cellular Biochem, Columbus, OH 43221 USA.
EM farooqui.1@osu.edu
RI frisardi, vincenza/Y-3309-2019; Panza, Francesco/Y-2539-2019; Panza,
   Francesco/M-6804-2017
OI frisardi, vincenza/0000-0003-0764-7387; Panza,
   Francesco/0000-0002-7220-0656
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NR 191
TC 120
Z9 134
U1 0
U2 37
PU SPRINGER BASEL AG
PI BASEL
PA PICASSOPLATZ 4, BASEL, 4052, SWITZERLAND
SN 1420-682X
EI 1420-9071
J9 CELL MOL LIFE SCI
JI Cell. Mol. Life Sci.
PD MAR
PY 2012
VL 69
IS 5
BP 741
EP 762
DI 10.1007/s00018-011-0840-1
PG 22
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA 898IR
UT WOS:000300736400006
PM 21997383
OA Green Published
DA 2025-06-11
ER

PT J
AU Dempsey, PC
   Howard, BJ
   Lynch, BM
   Owen, N
   Dunstan, DW
AF Dempsey, Paddy C.
   Howard, Bethany J.
   Lynch, Brigid M.
   Owen, Neville
   Dunstan, David W.
TI Associations of television viewing time with adults' well-being and
   vitality
SO PREVENTIVE MEDICINE
LA English
DT Article
DE Television viewing; Sedentary behaviour; Quality of life; Well-being;
   Vitality; Mental health; Gender; Physical activity
ID QUALITY-OF-LIFE; PHYSICAL-ACTIVITY; SEDENTARY BEHAVIOR; LEISURE-TIME;
   SITTING TIME; SCREEN-TIME; PSYCHOLOGICAL DISTRESS; CARDIOMETABOLIC RISK;
   METABOLIC SYNDROME; AUSTRALIAN ADULTS
AB Objective. Television (TV) viewing, a common leisure-time sedentary behaviour, is associated adversely with cardio-metabolic health, fatigue, depression and mental health. However, associations of TV viewing time with health-related quality of life attributes are less well understood. We examined associations of TV viewing time with physical well-being, mental well-being and vitality in a large population-based sample of Australian adults.
   Method. The study sample comprised 4,483 men and 5,424 women (mean age 51 +/- 14 years) from the Australian Diabetes, Obesity and Lifestyle study (1999-2000). Multiple linear regressions examined associations of TV viewing time (h/day) with the SF-36v1 physical and mental health component summary scores and the vitality sub-score, adjusting for leisure-time physical activity and waist circumference.
   Results. Each 1-h/day increment in TV viewing time was associated with lower physical (-0.56 [95% Cl: -0.77, -034]) and mental (-0.41 [-0.70, -0.12]) component summary scores and vitality (-0.51 [-0.81, -0.21]). Associations remained significant after adjustment for leisure-time physical activity and waist circumference. There was a gender interaction for the association of TV viewing time with vitality (significant in men only).
   Conclusions. TV viewing time is associated adversely with physical well-being, mental well-being and vitality. Further studies are required to better understand potential causal relationships and variations by gender and leisure-time physical activity. (C) 2014 Elsevier Inc. All rights reserved.
C1 [Dempsey, Paddy C.; Howard, Bethany J.; Lynch, Brigid M.; Owen, Neville; Dunstan, David W.] Baker IDI Heart & Diabet Inst, Melbourne, Vic 3004, Australia.
   [Dempsey, Paddy C.; Howard, Bethany J.; Owen, Neville; Dunstan, David W.] Monash Univ, Dept Med, Melbourne, Vic 3004, Australia.
   [Lynch, Brigid M.; Owen, Neville] Univ Melbourne, Melbourne Sch Populat & Global Hlth, Melbourne, Vic 3010, Australia.
   [Owen, Neville; Dunstan, David W.] Univ Queensland, Sch Populat Hlth, Brisbane, Qld, Australia.
   [Dunstan, David W.] Deakin Univ, Sch Exercise & Nutr Sci, Melbourne, Vic, Australia.
   [Dunstan, David W.] Monash Univ, Dept Epidemiol & Prevent Med, Melbourne, Vic 3004, Australia.
   [Dunstan, David W.] Univ Western Australia, Sch Sport Sci Exercise & Hlth, Perth, WA 6009, Australia.
C3 Baker Heart and Diabetes Institute; Monash University; University of
   Melbourne; University of Queensland; Deakin University; Monash
   University; University of Western Australia
RP Dempsey, PC (corresponding author), Baker IDI Heart & Diabet Inst, Phys Act & Behav Epidemiol Lab, 99 Commercial Rd, Melbourne, Vic 3004, Australia.
EM Paddy.Dempsey@bakeridi.edu.au
RI Dempsey, Paddy/LBH-0178-2024; Owen, Neville/IXN-9070-2023; Owen,
   Neville/K-5986-2012; Dunstan, David/E-8473-2010
OI Owen, Neville/0000-0003-2784-4820; Dunstan, David/0000-0003-2629-9568;
   Dempsey, Paddy/0000-0002-1714-6087; Lynch, Brigid/0000-0001-8060-547X
FU National Health and Medical Research Council [566940, 586727]; Victorian
   Government's OIS Program; Commonwealth Department of Health and Aged
   Care; Abbott Australasia Pty Ltd.; Alphapharm Pty Ltd.; Aventis
   Pharmaceutical; AstraZeneca; Bristol-Myers Squibb Pharmaceuticals; Eli
   Lilly (Aust) Pty Ltd.; GlaxoSmithKline; Janssen-Cilag (Aust) Pty Ltd.;
   Merck Lipha s.a; Merck Sharp 82 Dohme (Aust); Novartis Pharmaceutical
   (Aust) Pty Ltd.; Novo Nordisk Pharmaceutical Pty Ltd.; Pharmacia and
   Upjohn Pty Ltd.; Pfizer Pty Ltd.; Sanofi Synthelabo (Aust) Pty Ltd.;
   Servier Laboratories (Aust) Pty Ltd.; BioRad Laboratories Pty Ltd.;
   HITECH Pathology Pty Ltd.; Australian Kidney Foundation; Diabetes
   Australia; Diabetes Australia (Northern Territory); Queensland Health;
   South Australian Department of Human Services; Tasmanian Department of
   Health and Human Services; Territory Health Services; Victorian
   Department of Human Services; National Health and Medical Research
   Council/National Heart Foundation Postgraduate Scholarship [1056320];
   Australian Research Council Research Fellowship [FT100100918]; Senior
   Principal Research Fellowship [1003960]; Roche Diagnostics; Health
   Department of Western Australia
FX This work was supported by the following: National Health and Medical
   Research Council Program Grant [grant number 566940 to NO], National
   Health and Medical Research Council/National Heart Foundation
   Postgraduate Scholarship [grant number 1056320 to BJH], National Health
   and Medical Research Council Early Career Fellowship [grant number
   586727 to BML], Australian Research Council Research Fellowship to DWD
   [FT100100918] and Senior Principal Research Fellowship [grant number
   1003960 to NO]. This study was also supported in part by the Victorian
   Government's OIS Program. The funders of this study had no role in the
   data analysis or interpretation of the results. We are most grateful to
   the following for their support of the study: Commonwealth Department of
   Health and Aged Care, Abbott Australasia Pty Ltd., Alphapharm Pty Ltd.,
   Aventis Pharmaceutical, AstraZeneca, Bristol-Myers Squibb
   Pharmaceuticals, Eli Lilly (Aust) Pty Ltd., GlaxoSmithKline,
   Janssen-Cilag (Aust) Pty Ltd., Merck Lipha s.a., Merck Sharp 82 Dohme
   (Aust), Novartis Pharmaceutical (Aust) Pty Ltd., Novo Nordisk
   Pharmaceutical Pty Ltd., Pharmacia and Upjohn Pty Ltd., Pfizer Pty Ltd.,
   Roche Diagnostics, Sanofi Synthelabo (Aust) Pty Ltd., Servier
   Laboratories (Aust) Pty Ltd., BioRad Laboratories Pty Ltd., HITECH
   Pathology Pty Ltd., the Australian Kidney Foundation, Diabetes
   Australia, Diabetes Australia (Northern Territory), Queensland Health,
   South Australian Department of Human Services, Tasmanian Department of
   Health and Human Services, Territory Health Services, Victorian
   Department of Human Services and Health Department of Western Australia.
   Also, we are enormously grateful to the following for their invaluable
   contribution to the field activities of AusDiab: Annie Allman, Marita
   Dalton, Adam Meehan, Claire Reid, Alison Stewart, Robyn Tapp and Fay
   Wilson. The AusDiab Steering Committee consists of Dr. B. Atkins, Dr. S.
   Bennett, Dr. S. Chadban, Prof. S. Colagiuri, Dr. M. de Courten, Dr. M.
   D'Embden, Dr. D. Dunstan, Prof. T. Dwyer, Dr. D. Jolley, Dr. P. Magnus,
   Prof. J. Mathews, Dr. D. McCarty, Prof. K. O'Dea, Dr. P. Phillips, Dr.
   P. Popplewell, Mr. I. Kemp, Prof. H. Taylor, Prof. T. Welborn and Prof.
   P. Zimmet. We are most grateful to Parneet Sethi for statistical
   support; and especially the participants for volunteering their time to
   be in the study.
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NR 62
TC 26
Z9 30
U1 1
U2 44
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0091-7435
EI 1096-0260
J9 PREV MED
JI Prev. Med.
PD DEC
PY 2014
VL 69
BP 69
EP 74
DI 10.1016/j.ypmed.2014.09.007
PG 6
WC Public, Environmental & Occupational Health; Medicine, General &
   Internal
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health; General & Internal Medicine
GA AW3ZN
UT WOS:000346221600013
PM 25230366
DA 2025-06-11
ER

PT J
AU Alshehri, T
   Mook-Kanamori, DO
   van Dijk, KW
   Dinga, R
   Penninx, BWJH
   Rosendaal, FR
   le Cessie, S
   Milaneschi, Y
AF Alshehri, Tahani
   Mook-Kanamori, Dennis O.
   van Dijk, Ko Willems
   Dinga, Richard
   Penninx, Brenda W. J. H.
   Rosendaal, Frits R.
   le Cessie, Saskia
   Milaneschi, Yuri
TI Metabolomics dissection of depression heterogeneity and related
   cardiometabolic risk
SO PSYCHOLOGICAL MEDICINE
LA English
DT Article
DE Body fat distribution; body mass index; depression; metabolic syndrome;
   metabolomics
ID MAGNETIC-RESONANCE METABOLOMICS; ATYPICAL FEATURES; MAJOR DEPRESSION;
   EPIDEMIOLOGY; NETHERLANDS; OBESITY; INFLAMMATION; LEPTIN; LIPIDS
AB Background A recent hypothesis postulates the existence of an 'immune-metabolic depression' (IMD) dimension characterized by metabolic dysregulations. Combining data on metabolomics and depressive symptoms, we aimed to identify depressions associated with an increased risk of adverse metabolic alterations. Method Clustering data were from 1094 individuals with major depressive disorder in the last 6 months and measures of 149 metabolites from a H-1-NMR platform and 30 depressive symptoms (IDS-SR30). Canonical correlation analyses (CCA) were used to identify main independent metabolite-symptom axes of variance. Then, for the replication, we examined the association of the identified dimensions with metabolites from the same platform and cardiometabolic diseases in an independent population-based cohort (n = 6572). Results CCA identified an overall depression dimension and a dimension resembling IMD, in which symptoms such as sleeping too much, increased appetite, and low energy level had higher relative loading. In the independent sample, the overall depression dimension was associated with lower cardiometabolic risk, such as (i.e. per s.d.) HOMA-1B -0.06 (95% CI -0.09 - -0.04), and visceral adipose tissue -0.10 cm(2) (95% CI -0.14 - -0.07). In contrast, the IMD dimension was associated with well-known cardiometabolic diseases such as higher visceral adipose tissue 0.08 cm(2) (95% CI 0.04-0.12), HOMA-1B 0.06 (95% CI 0.04-0.09), and lower HDL-cholesterol levels -0.03 mmol/L (95% CI -0.05 - -0.01). Conclusions Combining metabolomics and clinical symptoms we identified a replicable depression dimension associated with adverse metabolic alterations, in line with the IMD hypothesis. Patients with IMD may be at higher cardiometabolic risk and may benefit from specific treatment targeting underlying metabolic dysregulations.
C1 [Alshehri, Tahani; Mook-Kanamori, Dennis O.; Rosendaal, Frits R.; le Cessie, Saskia] Leiden Univ, Dept Clin Epidemiol, Med Ctr, Leiden, Netherlands.
   [Mook-Kanamori, Dennis O.] Leiden Univ, Dept Publ Hlth & Primary Care, Med Ctr, Leiden, Netherlands.
   [van Dijk, Ko Willems] Leiden Univ, Dept Human Genet, Med Ctr, Leiden, Netherlands.
   [van Dijk, Ko Willems] Leiden Univ, Dept Internal Med, Div Endocrinol, Med Ctr, Leiden, Netherlands.
   [Dinga, Richard] Radboud Univ Nijmegen, Donders Inst Brain Cognit & Behav, Nijmegen, Netherlands.
   [Penninx, Brenda W. J. H.; Milaneschi, Yuri] Vrije Univ, Amsterdam Publ Hlth Res Inst, Dept Psychiat, Amsterdam Neurosci,Amsterdam UMC, Amsterdam, Netherlands.
   [le Cessie, Saskia] Leiden Univ, Dept Biomed Data Sci, Med Ctr, Leiden, Netherlands.
   [Milaneschi, Yuri] GGZ inGeest, Res & Innovat, Amsterdam, Netherlands.
C3 Leiden University; Leiden University Medical Center (LUMC); Leiden
   University - Excl LUMC; Leiden University - Excl LUMC; Leiden
   University; Leiden University Medical Center (LUMC); Leiden University -
   Excl LUMC; Leiden University; Leiden University Medical Center (LUMC);
   Leiden University; Leiden University Medical Center (LUMC); Leiden
   University - Excl LUMC; Radboud University Nijmegen; University of
   Amsterdam; Vrije Universiteit Amsterdam; Leiden University - Excl LUMC;
   Leiden University; Leiden University Medical Center (LUMC)
RP Alshehri, T (corresponding author), Leiden Univ, Dept Clin Epidemiol, Med Ctr, Leiden, Netherlands.
EM t.m.alshehri@lumc.nl
RI Penninx, Brenda/S-7627-2017; le+Cessie, Saskia/HGC-8966-2022; Alshehri,
   Tahani/IUP-1119-2023; van Dijk, Ko/A-1798-2008; Rosendaal,
   Frits/Q-3842-2017
OI Milaneschi, Yuri/0000-0002-3697-6617; Alshehri,
   Tahani/0000-0001-5500-4779
FU Geestkracht program of the Netherlands Organization for Health Research
   and Development (ZonMw) [10-000-1002]; VU University Medical Center; GGZ
   inGeest; Leiden University Medical Center; Leiden University; GGZ
   Rivierduinen; University Medical Center Groningen; University of
   Groningen; Lentis; GGZ Friesland; GGZ Drenthe; Rob Giel
   Onderzoekscentrum; Departments, Division, and Board of Directors of the
   Leiden University Medical Center; Leiden University, Research Profile
   Area Vascular and Regenerative Medicine; Dutch Science Organization
   (ZonMW-VENI Grant) [916.14.023]
FX NESDAThe infrastructure for the NESDA study (www.nesda.nl) is funded
   through the Geestkracht program of the Netherlands Organization for
   Health Research and Development (ZonMw, grant number: 10-000-1002) and
   financial contributions by participating universities and mental health
   care organizations (VU University Medical Center, GGZ inGeest, Leiden
   University Medical Center, Leiden University, GGZ Rivierduinen,
   University Medical Center Groningen, University of Groningen, Lentis,
   GGZ Friesland, GGZ Drenthe, Rob Giel Onderzoekscentrum).NEO studyThe NEO
   study is supported by the participating Departments, Division, and Board
   of Directors of the Leiden University Medical Center, and by the Leiden
   University, Research Profile Area Vascular and Regenerative Medicine.
   DOM-K is supported by Dutch Science Organization (ZonMW-VENI Grant No.
   916.14.023). We express our gratitude to all participants of the
   Netherlands Epidemiology of Obesity (NEO) study, in addition to all
   participating general practitioners. We furthermore thank P.R. van
   Beelen and all research nurses for collecting the data, P.J. Noordijk
   and her team for sample handling and storage, and I. de Jonge for data
   management of the NEO study.
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NR 52
TC 19
Z9 19
U1 3
U2 16
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0033-2917
EI 1469-8978
J9 PSYCHOL MED
JI Psychol. Med.
PD JAN
PY 2023
VL 53
IS 1
BP 248
EP 257
AR PII S0033291721001471
DI 10.1017/S0033291721001471
EA JUN 2021
PG 10
WC Psychology, Clinical; Psychiatry; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA 8K4BY
UT WOS:000785631100001
PM 34078486
OA Green Published, hybrid, Green Submitted
DA 2025-06-11
ER

PT J
AU Grozdan, AM
   Ghiuru, R
   Gavrilescu, CM
   Pandele, GI
   Chirita, R
   Popescu, FG
   Georgescu, C
AF Grozdan, Ana Minodora
   Ghiuru, Rodica
   Gavrilescu, Cristina-Maria
   Pandele, George Ioan
   Chirita, Roxana
   Popescu, Florina Georgeta
   Georgescu, Costinela
TI CORRELATION BETWEEN THE METABOLIC SYNDROME AND DEPRESSION IN REGARD OF
   POLYPATHOLOGY AND SPIRITUAL VIEW
SO EUROPEAN JOURNAL OF SCIENCE AND THEOLOGY
LA English
DT Article
DE depression; diabetes mellitus; hypertension; metabolic syndrome
ID OBESITY; STRESS
AB Any disease can be regarded as a result of the influence of external factors, but also as a spiritual imbalance of the human being. The link between the metabolic syndrome and depression on the basis of this presumption was studied, considering the fact that the imbalance of the so called,matter' may have the origin in a spiritual imbalance and vice versa. In order to study the correlation between metabolic syndrome-depression, 66 patients with metabolic syndrome were chosen, to whom there were applied questionnaires for depression. The patients were selected during January 2012 and May 2012 in the Vth Internal Medicine and Geriatrics-Gerontology Clinic, from the Railway Hospital Iasi. The preliminary data showed that depression (of different degrees) was associated to the 56 out of the 66 patients with metabolic syndrome (84.84%). The obese patients were the most affected suggesting the important part of the negative feelings (of unacceptance and self-rejection) played in their case. The ways of helping patients with these associated pathologies require a very complex approach, based on a interdisciplinary thinking and acting. Different medical specialists are needed, as well as a psychologist and even a father confessor, because cultivating Christian virtues will help patients fight stress, increase faith and love. Continuous prayer will balance their inner world, recreating it in health, peace and harmony.
C1 [Grozdan, Ana Minodora; Ghiuru, Rodica; Gavrilescu, Cristina-Maria; Pandele, George Ioan; Chirita, Roxana] Gr T Popa Univ Med & Pharm, Fac Med Iasi, Iasi 700115, Romania.
   [Grozdan, Ana Minodora; Chirita, Roxana] Psychiat Hosp Socola, Iasi 700282, Romania.
   [Ghiuru, Rodica; Gavrilescu, Cristina-Maria] Univ Railway Hosp, Iasi, Romania.
   [Pandele, George Ioan] Hosp Providenta Iasi, Iasi 700, Romania.
   [Popescu, Florina Georgeta] Dunarea de Jos Univ Galati, Fac Med & Pharm, Galati, Romania.
   [Georgescu, Costinela] Victor Babes Univ Med & Pharm, Fac Med Timisoara, Timisoara 300041, Romania.
C3 Alexandru Ioan Cuza University; Grigore T Popa University of Medicine &
   Pharmacy; Dunarea De Jos University Galati; Victor Babes University of
   Medicine & Pharmacy, Timisoara
RP Grozdan, AM (corresponding author), Gr T Popa Univ Med & Pharm, Fac Med Iasi, Str Univ 16, Iasi 700115, Romania.
EM crisgavrilescu@gmail.com
RI Gavrilescu, Cristina/LZE-7803-2025; popescu, florina/HZK-9016-2023
OI Gavrilescu, Cristina Maria/0000-0002-3423-3668
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NR 27
TC 0
Z9 0
U1 1
U2 14
PU ACAD ORGANISATION ENVIRONMENTAL ENGINEERING & SUSTAINABLE DEV
PI IASI
PA MANGERON BLVD NO 71A, PO 10, BOX 2111, IASI, 700050, ROMANIA
SN 1841-0464
EI 1842-8517
J9 EUR J SCI THEOL
JI Eur. J. Sci. Theol.
PD AUG
PY 2013
VL 9
IS 4
BP 183
EP 192
PG 10
WC Religion
WE Science Citation Index Expanded (SCI-EXPANDED); Arts &amp; Humanities Citation Index (A&amp;HCI)
SC Religion
GA 178UQ
UT WOS:000321473300014
DA 2025-06-11
ER

PT J
AU Bruins, J
   Pijnenborg, MGHM
   Bartels-Velthuis, AA
   Visser, E
   van den Heuvel, ER
   Bruggeman, R
   Jörg, F
AF Bruins, Jojanneke
   Pijnenborg, Marieke G. H. M.
   Bartels-Velthuis, Agna A.
   Visser, Ellen
   van den Heuvel, Edwin R.
   Bruggeman, Richard
   Jorg, Frederike
TI Cannabis use in people with severe mental illness: The association with
   physical and mental health - a cohort study. A Pharmacotherapy
   Monitoring and Outcome Survey study
SO JOURNAL OF PSYCHOPHARMACOLOGY
LA English
DT Article
DE Cannabis; metabolic syndrome; psychotic disorders; PANSS; severe mental
   illness
ID BODY-MASS INDEX; MARIJUANA USE; SOCIOECONOMIC-STATUS;
   INSULIN-RESISTANCE; METABOLIC SYNDROME; SUBSTANCE USE; RISK-FACTOR;
   FOLLOW-UP; SCHIZOPHRENIA; PSYCHOSIS
AB Objective: In the general population cannabis use is associated with better cardiometabolic outcomes. Patients with severe mental illness frequently use cannabis, but also present increased cardiometabolic risk factors. We explore the association between cannabis use and cardiometabolic risk factors in patients with severe mental illness.
   Method: A total of 3169 patients with severe mental illness from a Dutch cohort were included in the study. The association of cannabis use with body mass index, waist circumference, blood pressure, cholesterol, triglycerides, glucose, glycated hemoglobin and Positive and Negative Syndrome Scale was examined with separate univariate AN(C)OVA. Changes in metabolic risk factors and Positive and Negative Syndrome Scale were examined after a follow-up interval of 9-24 months, for patients who continued, discontinued, started or were never using cannabis between the two assessments.
   Results: Cannabis users at baseline had lower body mass index, smaller waist circumference, lower diastolic blood pressure, and more severe psychotic symptoms than non-users. Patients who discontinued their cannabis use after the first assessment had a greater increase in body mass index, waist circumference, diastolic blood pressure and triglyceride concentrations than other patients, and the severity of their psychotic symptoms had decreased more compared to continued users and non-users.
   Conclusion: Extra attention should be paid to the monitoring and treatment of metabolic parameters in patients who discontinue their cannabis use.
C1 [Bruins, Jojanneke; Bartels-Velthuis, Agna A.; Visser, Ellen; Bruggeman, Richard; Jorg, Frederike] Univ Groningen, Univ Med Ctr Groningen, Dept Psychiat, House Code CC72,Hanzeplein 1, NL-9713 GZ Groningen, Netherlands.
   [Pijnenborg, Marieke G. H. M.] Univ Groningen, Dept Clin Psychol & Expt Psychopathol, Groningen, Netherlands.
   [Pijnenborg, Marieke G. H. M.] GGZ Drenthe, Dept Psychot Disorders, Assen, Netherlands.
   [Bartels-Velthuis, Agna A.] Lentis Mental Hlth Org, Groningen, Netherlands.
   [van den Heuvel, Edwin R.] Eindhoven Univ Technol, Dept Math & Comp Sci, POB 513, NL-5600 MB Eindhoven, Netherlands.
   [Jorg, Frederike] Friesland Mental Hlth Serv, Res Dept, Leeuwarden, Netherlands.
C3 University of Groningen; University of Groningen; Eindhoven University
   of Technology
RP Bruins, J (corresponding author), Univ Med Ctr Groningen, Rob Giel Res Ctr, Dept Psychiat, House Code CC72,Hanzeplein 1, NL-9713 GZ Groningen, Netherlands.
EM j.bruins@umcg.nl
RI Jörg, Frederike/B-1325-2014; Van den Heuvel, Edwin/C-5166-2013
OI Bruins, Jojanneke/0000-0002-5345-0748; Bruggeman,
   Richard/0000-0002-3238-8471; Visser, Ellen/0000-0002-6370-5484
FU Rob Giel Research Center at the University Center for Psychiatry of the
   University Medical Center Groningen; Friesland Mental Health Services;
   GGZ Drenthe; Lentis Mental Health Organization
FX The authors disclosed receipt of the following financial support for the
   research, authorship, and/or publication of this article: his work was
   supported by the Rob Giel Research Center at the University Center for
   Psychiatry of the University Medical Center Groningen, Friesland Mental
   Health Services, GGZ Drenthe and Lentis Mental Health Organization.
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NR 47
TC 26
Z9 26
U1 0
U2 23
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0269-8811
EI 1461-7285
J9 J PSYCHOPHARMACOL
JI J. Psychopharmacol.
PD APR
PY 2016
VL 30
IS 4
BP 354
EP 362
DI 10.1177/0269881116631652
PG 9
WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA DG6OO
UT WOS:000372205400004
PM 26883305
DA 2025-06-11
ER

PT J
AU Schilling, R
   Colledge, F
   Ludyga, S
   Pühse, U
   Brand, S
   Gerber, M
AF Schilling, Rene
   Colledge, Flora
   Ludyga, Sebastian
   Puhse, Uwe
   Brand, Serge
   Gerber, Markus
TI Does Cardiorespiratory Fitness Moderate the Association between
   Occupational Stress, Cardiovascular Risk, and Mental Health in Police
   Officers?
SO INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
LA English
DT Article
DE cardiorespiratory fitness; cardiovascular health; psychosocial stress;
   police officers; mental health
ID EFFORT-REWARD IMBALANCE; INSOMNIA SEVERITY INDEX; JOB DECISION LATITUDE;
   PHYSICAL-ACTIVITY; AEROBIC FITNESS; CHRONIC DISEASE; WORK STRESS;
   DEMANDS; MORTALITY; SYMPTOMS
AB Background: Chronic exposure to occupational stress may lead to negative health consequences. Creating less stressful work environments and making employees physically and psychologically more resilient against stress are therefore two major public health concerns. This study examined whether cardiorespiratory fitness moderated the association between occupational stress, cardiovascular risk, and mental health. Methods: Stress was assessed via the Effort-Reward Imbalance and Job Demand-Control models in 201 police officers (36% women, Mage = 38.6 years). Higher levels of blood pressure, blood lipids, blood sugar, and unfavorable body composition were considered as cardiovascular risk factors. Burnout, insomnia and overall psychological distress were used as mental health indicators. Cardiorespiratory fitness was assessed with a submaximal bicycle test. Results: High cardiorespiratory fitness levels were associated with a reduced cardiometabolic risk, whereas high stress levels were associated with better mental health. Among participants who perceived a high Effort-Reward Imbalance, those with high fitness levels showed lower overall cardiovascular risk scores than their colleagues with low fitness levels. Conclusions: Work health programs for police officers should consider the early screening of burnout, sleep disturbances, and overall mental wellbeing. To increase cardiovascular health, including fitness tests in routine health checks and promoting physical activity to further increase cardiorespiratory fitness appears worthwhile.
C1 [Schilling, Rene; Colledge, Flora; Ludyga, Sebastian; Puhse, Uwe; Gerber, Markus] Univ Basel, Dept Sport Exercise & Hlth, CH-4052 Basel, Switzerland.
   [Brand, Serge] Univ Basel, Psychiat Clin, Ctr ff ect Stress & Sleep Disorders, CH-4052 Basel, Switzerland.
C3 University of Basel; Swiss School of Public Health (SSPH+); University
   of Basel
RP Schilling, R (corresponding author), Univ Basel, Dept Sport Exercise & Hlth, CH-4052 Basel, Switzerland.
EM rene.schilling@unibas.ch
RI Gerber, Markus/H-8654-2014; Brand, Serge/H-7159-2019; Ludyga,
   Sebastian/H-9316-2019
OI Gerber, Markus/0000-0001-6140-8948; Ludyga,
   Sebastian/0000-0002-3905-7894; Brand, Serge/0000-0003-2175-2765
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NR 94
TC 32
Z9 39
U1 1
U2 25
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1660-4601
J9 INT J ENV RES PUB HE
JI Int. J. Environ. Res. Public Health
PD JUL 1
PY 2019
VL 16
IS 13
AR 2349
DI 10.3390/ijerph16132349
PG 19
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA IL1DA
UT WOS:000477037900094
PM 31277211
OA Green Accepted, Green Published, gold
DA 2025-06-11
ER

PT J
AU Brocato, J
   Wu, F
   Chen, Y
   Shamy, M
   Alghamdi, MA
   Khoder, MI
   Alkhatim, AA
   Abdou, MH
   Costa, M
AF Brocato, Jason
   Wu, Fen
   Chen, Yu
   Shamy, Magdy
   Alghamdi, Mansour A.
   Khoder, Mamdouh I.
   Alkhatim, Alser A.
   Abdou, Mamdouh H.
   Costa, Max
TI Association between sleeping hours and cardiometabolic risk factors for
   metabolic syndrome in a Saudi Arabian population
SO BMJ OPEN
LA English
DT Article
ID CORONARY-HEART-DISEASE; NECROSIS-FACTOR-ALPHA; PARTICULATE MATTER;
   INSULIN-RESISTANCE; DURATION; MORTALITY; OBESITY; METAANALYSIS;
   DEPRESSION; WOMEN
AB Objectives: Epidemiological and molecular studies have shown that sleep duration is associated with metabolic syndrome (MtS), a disease that is on the rise in the Kingdom of Saudi Arabia. We aim to investigate the association between sleep duration and selected cardiometabolic risk factors of MtS in a Saudi Arabian population.
   Setting: Secondary care was given to the participants. There were 2 participating centres, shopping malls in North and South Jeddah, Saudi Arabia.
   Participants: We recruited 2686 participants over a 1-year study period. Participants were selected based on their willingness. The only criterion for exclusion was living in the area (North or South Jeddah) for less than 15 years.
   Planned and primary outcome measures: Participants were measured for blood sugar levels, blood pressure and body mass index. All participants were asked to fill out a questionnaire.
   Results: There was a positive association between longer sleep duration and obesity, hypertension and hyperglycaemia. The adjusted ORs for obesity, hypertension and hyperglycaemia were 1.54 (95% CI 1.20 to 1.98), 1.89 (95% CI 1.45 to 2.48) and 1.59 (95% CI 1.19 to 2.13), respectively, in participants sleeping > 8 h/night, as compared with those sleeping 7 h. The positive associations between longer sleep duration, defined as sleeping > 7 h, and the disease status, did not differ from other risk factors such as physical activity and nutrition.
   Conclusions: This is the first epidemiological study reporting on the association between sleep duration and cardiometabolic risk factors of MtS in a Saudi Arabian population. Sleep durations of 8 h or greater were found to be associated with all 3 cardiometabolic risk factors: obesity, hypertension and hyperglycaemia, and this relationship was not confounded by quality of nutrition or physical activity levels.
C1 [Brocato, Jason; Chen, Yu; Costa, Max] NYU, Sch Med, Dept Environm Med, New York, NY USA.
   [Wu, Fen; Chen, Yu] NYU, Sch Med, Dept Populat Hlth, New York, NY USA.
   [Shamy, Magdy; Alghamdi, Mansour A.; Khoder, Mamdouh I.; Alkhatim, Alser A.; Abdou, Mamdouh H.] King Abdulaziz Univ, Fac Meteorol Environm & Arid Land Agr, Dept Environm Sci, Jeddah 21413, Saudi Arabia.
   [Khoder, Mamdouh I.] King Abdulaziz Univ, Ctr Excellence Environm Studies, Jeddah 21413, Saudi Arabia.
C3 New York University; New York University; King Abdulaziz University;
   King Abdulaziz University
RP Costa, M (corresponding author), NYU, Sch Med, Dept Environm Med, New York, NY USA.
EM Max.Costa@nyumc.org
RI Chen, Yu/KWU-0062-2024; Al-Ghamdi, Prof. Dr. Mohammed/ISU-9198-2023;
   Alghamdi, Mansour/B-7085-2014; Khoder, Mamdouh/I-7583-2012
OI Al-Ghamdi, Prof. Dr. Mohammed/0000-0002-9794-554X; Alghamdi,
   Mansour/0000-0001-7518-659X; Khoder, Mamdouh/0000-0001-8867-1295; Chen,
   Yu/0000-0002-1519-4894
FU King Abdulaziz University (KAU), Jeddah [4/00/00/252]; National
   Institute of Health (NIH) [ES000260, ES010344, ES014454, ES022935,
   ES023174]
FX This study was supported by the King Abdulaziz University (KAU), Jeddah
   (grant number 4/00/00/252); and by the National Institute of Health
   (NIH) (grant numbers ES000260, ES010344, ES014454, ES022935, ES023174).
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NR 36
TC 19
Z9 19
U1 2
U2 13
PU BMJ PUBLISHING GROUP
PI LONDON
PA BRITISH MED ASSOC HOUSE, TAVISTOCK SQUARE, LONDON WC1H 9JR, ENGLAND
SN 2044-6055
J9 BMJ OPEN
JI BMJ Open
PY 2015
VL 5
IS 11
AR e008590
DI 10.1136/bmjopen-2015-008590
PG 8
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA DB9MK
UT WOS:000368840100014
PM 26621514
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Vogelzangs, N
   Beekman, ATF
   Boelhouwer, IG
   Bandinelli, S
   Milaneschi, Y
   Ferrucci, L
   Penninx, BWJH
AF Vogelzangs, Nicole
   Beekman, Aartjan T. F.
   Boelhouwer, Ingrid G.
   Bandinelli, Stefania
   Milaneschi, Yuri
   Ferrucci, Luigi
   Penninx, Brenda W. J. H.
TI Metabolic Depression: A Chronic Depressive Subtype? Findings From the
   InCHIANTI Study of Older Persons
SO JOURNAL OF CLINICAL PSYCHIATRY
LA English
DT Article
ID TREATMENT PANEL-III; C-REACTIVE PROTEIN; YOUNG-ADULTS; LARGE-COHORT;
   SYMPTOMS; ASSOCIATION; ANXIETY; HEALTH; RISK; HEART
AB Objective: Several studies report a cross-sectional association between metabolic syndrome and depression. Possibly, metabolic syndrome promotes onset or chronicity of depression. However, such a longitudinal link has not yet been confirmed. This study examines whether metabolic syndrome or its components are associated with onset and chronicity of depression.
   Method: Secondary analyses were performed on data from 823 participants (>= 65 years of age) in the InCHIANTI study, a prospective, population-based cohort study of older persons. From 1998 to 2000, the study sample was randomly selected from the population registry of 2 sites in Italy using a multistage stratified sampling method. Baseline data collection consisted of a home interview and a medical evaluation at the study clinic. Follow-up for each participant occurred after 3 years and 6 years. Metabolic syndrome at baseline was defined as >= 3 of the following: abdominal obesity, high triglycerides, low high-density lipoprotein cholesterol, high blood pressure, and high fasting glucose. Depressive symptoms were assessed using the Center for Epidemiologic Studies Depression scale (CES-D) at baseline and after 3 and 6 years. Sample characteristics were compared between persons with and without depression at baseline using chi(2) and t statistics. Logistic regression analyses were conducted separately in persons with and without depression at baseline to test whether metabolic syndrome at baseline could predict onset and chronicity of depression at follow-up.
   Results: At baseline, 235 persons had metabolic syndrome, and 168 were depressed (CES-D score >= 20). Among persons not depressed at baseline, 26.0% developed depression. Higher waist circumference increased the odds of depression onset (adjusted OR per SD increase =1.28; 95% CI, 1.05-1.56), but there was no association between other metabolic syndrome components and onset of depression. Among persons depressed at baseline, depression had a chronic character in 69.0% of persons without and 88.5% of persons with metabolic syndrome. Metabolic syndrome was associated with an almost 3-fold increase in the odds of chronicity of depression (adjusted OR = 2.66; 95% CI, 1.01-7.00), with almost every metabolic syndrome component contributing to this association.
   Conclusion: In late life, waist circumference, but not metabolic syndrome, predicted onset of depression. Depressed persons with metabolic syndrome were more likely to have persistent or recurrent depression. The latter may suggest that depression with metabolic abnormalities, which could be labeled metabolic depression, identifies a chronic subtype of depression. J Clin Psychiatry 2011;72(5):598-604 (C) Copyright 2011 Physicians Postgraduate Press, Inc.
C1 [Vogelzangs, Nicole; Beekman, Aartjan T. F.; Boelhouwer, Ingrid G.; Penninx, Brenda W. J. H.] Vrije Univ Amsterdam Med Ctr, Dept Psychiat, NL-1081 HL Amsterdam, Netherlands.
   [Vogelzangs, Nicole; Beekman, Aartjan T. F.; Boelhouwer, Ingrid G.; Penninx, Brenda W. J. H.] Vrije Univ Amsterdam Med Ctr, EMGO Inst Hlth & Care Res, NL-1081 HL Amsterdam, Netherlands.
   [Bandinelli, Stefania] Azienda Sanit Firenze, Geriatr Rehabil, Florence, Italy.
   [Milaneschi, Yuri; Ferrucci, Luigi] NIA, Clin Res Branch, Baltimore, MD 21224 USA.
   [Milaneschi, Yuri] Tuscany Hlth Reg Agcy, Florence, Italy.
C3 Vrije Universiteit Amsterdam; VU UNIVERSITY MEDICAL CENTER; Vrije
   Universiteit Amsterdam; VU UNIVERSITY MEDICAL CENTER; Azienda Sanitaria
   di Firenze; National Institutes of Health (NIH) - USA; NIH National
   Institute on Aging (NIA)
RP Vogelzangs, N (corresponding author), Vrije Univ Amsterdam Med Ctr, Dept Psychiat, AJ Ernststr 1187, NL-1081 HL Amsterdam, Netherlands.
EM n.vogelzangs@vumc.nl
RI bandinelli, stefania/AAL-4570-2020; Penninx, Brenda/S-7627-2017;
   Ferrucci, Luigi/AED-9724-2022; Beekman, Aartjan T./LUZ-6919-2024
OI Milaneschi, Yuri/0000-0002-3697-6617; Ferrucci,
   Luigi/0000-0002-6273-1613; Bandinelli, Stefania/0000-0002-6491-0850
FU National Heart, Lung, and Blood Institute, Bethesda, Maryland
   [1R01-HL972972]; Italian Ministry of Health [ICS 110.1/RS97.71]; US
   National Institute on Aging, Bethesda, Maryland [263 MD 916413, 263 MD
   821336]
FX These data analyses were supported through grant 1R01-HL972972 from the
   National Heart, Lung, and Blood Institute, Bethesda, Maryland. The
   original InCHIANTI study was supported as a targeted project (ICS
   110.1/RS97.71) by the Italian Ministry of Health and was supported in
   part by the US National Institute on Aging, Bethesda, Maryland (263 MD
   916413 and 263 MD 821336).
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NR 52
TC 79
Z9 86
U1 0
U2 21
PU PHYSICIANS POSTGRADUATE PRESS
PI MEMPHIS
PA P O BOX 752870, MEMPHIS, TN 38175-2870 USA
SN 0160-6689
EI 1555-2101
J9 J CLIN PSYCHIAT
JI J. Clin. Psychiatry
PD MAY
PY 2011
VL 72
IS 5
BP 598
EP 604
DI 10.4088/JCP.10m06559
PG 7
WC Psychology, Clinical; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA 772NM
UT WOS:000291240600005
PM 21535996
OA Green Accepted
DA 2025-06-11
ER

PT J
AU Zijlema, WL
   Klijs, B
   Stolk, RP
   Rosmalen, JGM
AF Zijlema, Wilma L.
   Klijs, Bart
   Stolk, Ronald P.
   Rosmalen, Judith G. M.
TI (Un)Healthy in the City: Respiratory, Cardiometabolic and Mental Health
   Associated with Urbanity
SO PLOS ONE
LA English
DT Article
ID RISK-FACTORS; BLOOD-PRESSURE; PHYSICAL-ACTIVITY; BREAST-CANCER;
   AIR-POLLUTION; OBESITY; NEIGHBORHOODS; URBANIZATION; ENVIRONMENTS;
   MORTALITY
AB Background
   Research has shown that health differences exist between urban and rural areas. Most studies conducted, however, have focused on single health outcomes and have not assessed to what extent the association of urbanity with health is explained by population composition or socioeconomic status of the area. Our aim is to investigate associations of urbanity with four different health outcomes (i. e. lung function, metabolic syndrome, depression and anxiety) and to assess whether these associations are independent of residents' characteristics and area socioeconomic status.
   Methods
   Our study population consisted of 74,733 individuals (42% males, mean age 43.8) who were part of the baseline sample of the LifeLines Cohort Study. Health outcomes were objectively measured with spirometry, a physical examination, laboratory blood analyses, and a psychiatric interview. Using multilevel linear and logistic regression models, associations of urbanity with lung function, and prevalence of metabolic syndrome, major depressive disorder and generalized anxiety disorder were assessed. All models were sequentially adjusted for age, sex, highest education, household equivalent income, smoking, physical activity, and mean neighborhood income.
   Results
   As compared with individuals living in rural areas, those in semi-urban or urban areas had a poorer lung function (beta-1.62, 95% CI -2.07;-1.16), and higher prevalence of major depressive disorder (OR 1.65, 95% CI 1.35; 2.00), and generalized anxiety disorder (OR 1.58, 95% CI 1.35; 1.84). Prevalence of metabolic syndrome, however, was lower in urban areas (OR 0.51, 95% CI 0.44; 0.59). These associations were only partly explained by differences in residents' demographic, socioeconomic and lifestyle characteristics and socioeconomic status of the areas.
   Conclusions
   Our results suggest a differential health impact of urbanity according to type of disease. Living in an urban environment appears to be beneficial for cardiometabolic health but to have a detrimental impact on respiratory function and mental health. Future research should investigate which underlying mechanisms explain the differential health impact of urbanity.
C1 [Zijlema, Wilma L.; Klijs, Bart; Stolk, Ronald P.] Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, Groningen, Netherlands.
   [Rosmalen, Judith G. M.] Univ Groningen, Univ Med Ctr Groningen, Dept Psychiat, Groningen, Netherlands.
C3 University of Groningen; University of Groningen
RP Zijlema, WL (corresponding author), Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, Groningen, Netherlands.
EM w.l.zijlema@umcg.nl
RI Klijs, Bart/B-3330-2013; Zijlema, Wilma/AAE-2409-2021; Stolk,
   Ronald/B-2341-2013; Rosmalen, Judith/F-5375-2011
OI Rosmalen, Judith/0000-0002-6393-0032; Zijlema,
   Wilma/0000-0002-6257-5091; Stolk, Ronald/0000-0002-0518-1205
FU European Union Seventh Framework Programme (FP7) [261433]; Netherlands
   Organization of Scientific Research NWO [175.010.2007.006]; Economic
   Structure Enhancing Fund (FES) of the Dutch government; Ministry of
   Economic Affairs; Ministry of Education, Culture and Science; Ministry
   for Health, Welfare and Sports; Northern Netherlands Collaboration of
   Provinces; Province of Groningen; University Medical Center Groningen;
   University of Groningen; Dutch Kidney Foundation; Dutch Diabetes
   Research Foundation; European Union Seventh Framework Programme (FP7)
   [261433]; Netherlands Organization of Scientific Research NWO
   [175.010.2007.006]; Economic Structure Enhancing Fund (FES) of the Dutch
   government; Ministry of Economic Affairs; Ministry of Education, Culture
   and Science; Ministry for Health, Welfare and Sports; Northern
   Netherlands Collaboration of Provinces; Province of Groningen;
   University Medical Center Groningen; University of Groningen; Dutch
   Kidney Foundation; Dutch Diabetes Research Foundation
FX The research leading to these results received funding from the European
   Union Seventh Framework Programme (FP7/2007-2013) under grant agreement
   n<SUP>o</SUP>261433 (Biobank Standardisation and Harmonisation for
   Research Excellence in the European Union-BioSHaRE-EU). The LifeLines
   Cohort Study, and generation and management of GWAS genotype data for
   the LifeLines Cohort Study was supported by the Netherlands Organization
   of Scientific Research NWO (grant 175.010.2007.006), the Economic
   Structure Enhancing Fund (FES) of the Dutch government, the Ministry of
   Economic Affairs, the Ministry of Education, Culture and Science, the
   Ministry for Health, Welfare and Sports, the Northern Netherlands
   Collaboration of Provinces (SNN), the Province of Groningen, University
   Medical Center Groningen, the University of Groningen, Dutch Kidney
   Foundation and Dutch Diabetes Research Foundation. The funders had no
   role in study design, data collection and analysis, decision to publish,
   or preparation of the manuscript.
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NR 37
TC 46
Z9 47
U1 0
U2 26
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD DEC 2
PY 2015
VL 10
IS 12
AR e0143910
DI 10.1371/journal.pone.0143910
PG 11
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA CX8BI
UT WOS:000365926300120
PM 26630577
OA Green Published, gold, Green Submitted
DA 2025-06-11
ER

PT J
AU Luppino, FS
   Bouvy, PF
   Giltay, EJ
   Penninx, BWJH
   Zitman, FG
AF Luppino, Floriana S.
   Bouvy, Paul F.
   Giltay, Erik J.
   Penninx, Brenda W. J. H.
   Zitman, Frans G.
TI The metabolic syndrome and related characteristics in major depression:
   inpatients and outpatients compared Metabolic differences across
   treatment settings
SO GENERAL HOSPITAL PSYCHIATRY
LA English
DT Article
DE Metabolic syndrome; Metabolic characteristics; Major depressive
   disorder; Inpatients; Outpatients
ID DISEASE RISK-FACTORS; BODY-MASS INDEX; BLOOD-PRESSURE;
   CARDIOVASCULAR-DISEASE; ANXIETY; ASSOCIATION; SYMPTOMS; HEART; MEN;
   INFLAMMATION
AB Objective: We aimed to systematically compare patients with major depressive disorder from three different treatment settings (a primary care outpatient, a secondary care outpatient and one inpatient sample), with regard to metabolic syndrome (MetSyn) prevalences, individual MetSyn components and related metabolic variables.
   Method: The outpatient samples were drawn from the ongoing Netherlands Study of Depression and Anxiety (302 primary care and 445 secondary care outpatients). The inpatient sample (n=80) was recruited from five Dutch mental health hospitals. The assessments of MetSyn and related variables [waist circumference (WC), high-density lipoprotein (HDL) and low-density lipoprotein (LDL) cholesterol, triglycerides, glucose, systolic and diastolic blood pressure (SBP, DBP), body mass index (BMI), waist-hip ratio (WHR), LDL and total cholesterol (TC)] were compared using analysis of (co)variance and regression analysis, whereas medication analyses examined the extent to which clinical differences (e. g., depression severity or medication use) mediated the observed metabolic differences across setting.
   Results: MetSyn prevalences (26% primary, 24% secondary care and 28% inpatients) did not significantly differ (P=.71). WC, BMI, LDL cholesterol, glucose and DBP were not significantly different across settings. However, WHR, TC and triglyceride levels were higher in inpatients than in both outpatients groups, while HDL cholesterol levels and SBP were lower. There was some mediating role for tricyclic and non-selective serotonin-reuptake inhibitor antidepressant use, but overall, the mediating role of clinical differences was limited.
   Conclusions: Although overall MetSyn prevalences did not differ, patterns of individual MetSyn-related variables differed more markedly across depressed inpatients and outpatients. Inpatients showed more adverse WHR and serum lipid profiles, while SBP levels were lower. (C) 2014 Elsevier Inc. All rights reserved.
C1 [Luppino, Floriana S.; Giltay, Erik J.; Penninx, Brenda W. J. H.; Zitman, Frans G.] LUMC, Dept Psychiat, NL-2300 RC Leiden, Netherlands.
   [Luppino, Floriana S.; Giltay, Erik J.; Penninx, Brenda W. J. H.; Zitman, Frans G.] GGZ Rivierduinen, Leiden, Netherlands.
   [Bouvy, Paul F.] Erasmus MC, Dept Psychiat, Rotterdam, Netherlands.
   [Penninx, Brenda W. J. H.] EMGO VU Univ Med Ctr, Dept Psychiat, Amsterdam, Netherlands.
   [Penninx, Brenda W. J. H.] Univ Groningen, Univ Med Ctr Groningen, Dept Psychiat, NL-9713 AV Groningen, Netherlands.
C3 Leiden University; Leiden University Medical Center (LUMC); Erasmus
   University Rotterdam; Erasmus MC; University of Groningen
RP Luppino, FS (corresponding author), LUMC, Dept Psychiat, B1-P,POB 9600, NL-2300 RC Leiden, Netherlands.
EM f.s.luppino@lumc.nl; p.bouvy@erasmusmc.nl; e.j.giltay@lumc.nl;
   b.penninx@vumc.nl; f.g.zitman@lumc.nl
RI Giltay, Erik/AAL-9948-2021; Zitman, Frans/E-7705-2010; Penninx,
   Brenda/S-7627-2017
OI Giltay, Erik J./0000-0001-8874-2292
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NR 63
TC 14
Z9 15
U1 1
U2 14
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0163-8343
EI 1873-7714
J9 GEN HOSP PSYCHIAT
JI Gen. Hosp. Psych.
PD SEP
PY 2014
VL 36
IS 5
BP 509
EP 515
DI 10.1016/j.genhosppsych.2014.05.018
PG 7
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA AN8RT
UT WOS:000340872400015
PM 25001528
DA 2025-06-11
ER

PT J
AU Gaydosh, L
   Schorpp, KM
   Chen, E
   Miller, GE
   Harris, KM
AF Gaydosh, Lauren
   Schorpp, Kristen M.
   Chen, Edith
   Miller, Gregory E.
   Harris, Kathleen Mullan
TI College completion predicts lower depression but higher metabolic
   syndrome among disadvantaged minorities in young adulthood
SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF
   AMERICA
LA English
DT Article
DE social mobility; health disparities; race and ethnic disparities; young
   adulthood
ID JOHN-HENRYISM; UNITED-STATES; SOCIOECONOMIC-STATUS; ALLOSTATIC LOAD;
   BLOOD-PRESSURE; MENTAL-HEALTH; RACIAL DISPARITIES; AFRICAN-AMERICANS;
   INCOME INEQUALITY; MOBILITY
AB Individuals with higher educational attainment live healthier and longer lives. However, not everyone benefits equally from higher education. In particular, the black-white gap in life expectancy is greater at higher levels of educational attainment. Furthermore, recent research suggests that disadvantaged African Americans in the rural Southeast who attend college have worse physical health than their similarly disadvantaged peers who do not attend college. The extent to which this pattern generalizes to a nationally representative, mixed-race sample is unknown. Using data from the National Longitudinal Study of Adolescent to Adult Health, we test whether the health benefits associated with college completion vary by level of childhood disadvantage for depression and metabolic syndrome in young adulthood, across race/ethnicity. We find uniform lower depression associated with college completion regardless of childhood disadvantage, and across non-Hispanic white, non-Hispanic black, and Hispanic young adults. College completion is associated with lower metabolic syndrome for whites across all levels of childhood disadvantage. In contrast, college completion is associated with higher metabolic syndrome among black and Hispanic young adults from disadvantaged childhood environments. Our findings suggest that, for minorities from disadvantaged backgrounds, finishing college pays substantial dividends for mental health but simultaneously exacts costs with regard to physical health. This pattern contrasts starkly with whites and minorities from more privileged backgrounds, for whom college completion is associated with benefits to both mental and physical health. These results suggest that racial disparities in health may persist in part because the health of upwardly mobile minorities is compromised in young adulthood.
C1 [Gaydosh, Lauren; Harris, Kathleen Mullan] Univ North Carolina Chapel Hill, Carolina Populat Ctr, Chapel Hill, NC 27516 USA.
   [Schorpp, Kristen M.] Roanoke Coll, Dept Sociol, Salem, VA 24153 USA.
   [Chen, Edith; Miller, Gregory E.] Northwestern Univ, Inst Policy Res, Evanston, IL 60208 USA.
   [Chen, Edith; Miller, Gregory E.] Northwestern Univ, Dept Psychol, Evanston, IL 60208 USA.
   [Harris, Kathleen Mullan] Univ North Carolina Chapel Hill, Dept Sociol, Chapel Hill, NC 27599 USA.
C3 University of North Carolina; University of North Carolina Chapel Hill;
   University of North Carolina School of Medicine; Northwestern
   University; Northwestern University; University of North Carolina;
   University of North Carolina Chapel Hill; University of North Carolina
   School of Medicine
RP Harris, KM (corresponding author), Univ North Carolina Chapel Hill, Carolina Populat Ctr, Chapel Hill, NC 27516 USA.; Harris, KM (corresponding author), Univ North Carolina Chapel Hill, Dept Sociol, Chapel Hill, NC 27599 USA.
EM kathie_harris@unc.edu
OI Miller, Gregory/0000-0002-7217-1082
FU Eunice Kennedy Shriver National Institute of Child Health and Human
   Development (NICHD) Grants [F32-HD084117, P01-HD31921, P2C-HD050924];
   NICHD Grant [P01-HD31921]; Russell Sage Foundation Working Group in
   Biology and Social Science
FX This research was supported by Eunice Kennedy Shriver National Institute
   of Child Health and Human Development (NICHD) Grants F32-HD084117,
   P01-HD31921, and P2C-HD050924. This research uses data from Add Health,
   a program project directed by K.M.H. and designed by J. Richard Udry,
   Peter S. Bearman, and K.M.H. at the University of North Carolina at
   Chapel Hill and funded by NICHD Grant P01-HD31921 with cooperative
   funding from 23 other federal agencies and foundations. We also
   acknowledge the support of the Russell Sage Foundation Working Group in
   Biology and Social Science.
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NR 65
TC 97
Z9 113
U1 0
U2 26
PU NATL ACAD SCIENCES
PI WASHINGTON
PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA
SN 0027-8424
J9 P NATL ACAD SCI USA
JI Proc. Natl. Acad. Sci. U. S. A.
PD JAN 2
PY 2018
VL 115
IS 1
BP 109
EP 114
DI 10.1073/pnas.1714616114
PG 6
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Science & Technology - Other Topics
GA FR5TI
UT WOS:000419128700036
PM 29255040
OA hybrid, Green Published
DA 2025-06-11
ER

PT J
AU Zheng, H
   Echave, P
AF Zheng, Hui
   Echave, Paola
TI Are Recent Cohorts Getting Worse? Trends in US Adult Physiological
   Status, Mental Health, and Health Behaviors Across a Century of Birth
   Cohorts
SO AMERICAN JOURNAL OF EPIDEMIOLOGY
LA English
DT Article
DE cohort analysis; gender disparities; health behaviors; mental health;
   morbidity and mortality; obesity; physiological status; racial
   disparities
ID OLDER AMERICANS; UNITED-STATES; CHRONIC DISABILITY; METABOLIC SYNDROME;
   LIFE EXPECTANCY; MORTALITY; COMPRESSION; POPULATION; PREVALENCE;
   MORBIDITY
AB Morbidity and mortality have been increasing among middle-aged and young-old Americans since the turn of the century. We investigated whether these unfavorable trends extend to younger cohorts and their underlying physiological, psychological, and behavioral mechanisms. Applying generalized linear mixed-effects models to data from 62,833 adults from the National Health and Nutrition Examination Surveys (1988-2016) and 625,221 adults from the National Health Interview Surveys (1997-2018), we found that for all sex and racial groups, physiological dysregulation has increased continuously from Baby Boomers through late-Generation X and Generation Y. The magnitude of the increase was higher for White men than for other groups, while Black men had a steepest increase in low urinary albumin (a marker of chronic inflammation). In addition, Whites underwent distinctive increases in anxiety, depression, and heavy drinking, and they had a higher level than Blacks and Hispanics of smoking and drug use in recent cohorts. Smoking is not responsible for the increasing physiological dysregulation across cohorts. The obesity epidemic contributes to the increase in metabolic syndrome but not in low urinary albumin. The worsening physiological and mental health profiles among younger generations imply a challenging morbidity and mortality prospect for the United States, one that might be particularly inauspicious for Whites.
C1 [Zheng, Hui; Echave, Paola] Ohio State Univ, Inst Populat Res, Columbus, OH 43210 USA.
   [Zheng, Hui; Echave, Paola] Ohio State Univ, Dept Sociol, 106 Townsend Hall,1885 Neil Ave Mall, Columbus, OH 43210 USA.
C3 University System of Ohio; Ohio State University; University System of
   Ohio; Ohio State University
RP Zheng, H (corresponding author), Ohio State Univ, Dept Sociol, 106 Townsend Hall,1885 Neil Ave Mall, Columbus, OH 43210 USA.
EM zheng.64@osu.edu
RI Zheng, Hui/K-3735-2012
OI Zheng, Hui/0000-0003-3085-4560
FU Eunice Kennedy Shriver National Institute for Child Health and Human
   Development [P2CHD058484]; National Institute on Aging [R03AG053463];
   Centers for Disease Control and Prevention [R03SH000046]
FX This publication was supported by the Eunice Kennedy Shriver National
   Institute for Child Health and Human Development (grant P2CHD058484),
   the National Institute on Aging (grant R03AG053463), and the Centers for
   Disease Control and Prevention (grant R03SH000046).
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NR 38
TC 37
Z9 43
U1 0
U2 10
PU OXFORD UNIV PRESS INC
PI CARY
PA JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA
SN 0002-9262
EI 1476-6256
J9 AM J EPIDEMIOL
JI Am. J. Epidemiol.
PD NOV
PY 2021
VL 190
IS 11
BP 2242
EP 2255
DI 10.1093/aje/kwab076
PG 14
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA YH4LA
UT WOS:000743139000002
PM 33738469
OA Green Published
DA 2025-06-11
ER

PT J
AU Moreira, FP
   Jansen, K
   Cardoso, TD
   Mondin, TC
   Magalhaes, PV
   Kapczinski, F
   Souza, LDM
   da Silva, RA
   Oses, JP
   Wiener, CD
AF Moreira, Fernanda Pedrotti
   Jansen, Karen
   Cardoso, Taiane de A.
   Mondin, Thaise C.
   Magalhaes, Pedro V.
   Kapczinski, Flavio
   Souza, Luciano D. M.
   da Silva, Ricardo A.
   Oses, Jean Pierre
   Wiener, Carolina D.
TI Metabolic syndrome and psychiatric disorders: a population-based study
SO BRAZILIAN JOURNAL OF PSYCHIATRY
LA English
DT Article
DE Metabolic syndrome; psychiatric disorders; mood disorders; anxiety
   disorders; suicide
ID BIPOLAR-DISORDER; PSYCHOTIC DISORDERS; ASSOCIATION; METAANALYSIS;
   PREVALENCE; RISK; DETERMINANTS; DEPRESSION; CHINESE; PEOPLE
AB Objective: To identify the association of metabolic syndrome (MetS) and psychiatric disorders in young adults in southern Brazil.
   Methods: This population based cross-sectional study involved a total of 1,023 young adults between the ages of 21 and 32 years. Current episodes of psychiatric disorders were assessed using the Mini International Neuropsychiatric Interview-Plus version. MetS was evaluated using the National Cholesterol Education Program Adult Treatment Panel III (NCEP/ATP III).
   Results: Of the 1,023 participants, 24.3% were identified with MetS, 13.5% were diagnosed with anxiety disorders, 7.5% with current depression, 3.9% with bipolar disorders and 10.1% were at risk of suicide. MetS was associated with ethnicity (p = 0.022), excess weight (p < 0.001), current anxiety disorders (p < 0.001), current mood disorders (bipolar disorder in mood episode and current depression) (p < 0.001), and suicide risk (p < 0.001).
   Conclusions: MetS was associated with psychiatric disorders. Awareness of factors associated with MetS can help identify high-risk individuals and stimulate disease prevention and control programs, as well as lifestyle changes.
C1 [Moreira, Fernanda Pedrotti; Jansen, Karen; Cardoso, Taiane de A.; Mondin, Thaise C.; Souza, Luciano D. M.; da Silva, Ricardo A.; Oses, Jean Pierre; Wiener, Carolina D.] Univ Catolica Pelotas UCPel, Dept Saude & Comportamento, Ciencia Translac Transtornos Cerebrais, Pelotas, RS, Brazil.
   [Magalhaes, Pedro V.; Kapczinski, Flavio] Univ Fed Rio Grande do Sul, Psiquiatria Mol, Programa Posgrad Psiquiatria & Ciencias Comportam, Porto Alegre, RS, Brazil.
   [Kapczinski, Flavio] McMaster Univ, Hamilton, ON, Canada.
   [Wiener, Carolina D.] Anhanguera Educ Rio Grande, Rio Grande, RS, Brazil.
C3 Universidade Catolica de Pelotas; Universidade Federal do Rio Grande do
   Sul; McMaster University
RP Jansen, K (corresponding author), Rua Goncalves Chaves,373,Sala 424C, BR-96015560 Pelotas, RS, Brazil.
EM karen.jansen@pq.cnpq.br
RI Oses, Jean/E-2534-2013; Pedrotti Moreira, Fernanda/JRX-8306-2023;
   Jansen, Karen/O-3128-2015; Kapczinski, Flavio/D-3175-2013; Magalhaes,
   Pedro/A-8519-2008
OI Jansen, Karen/0000-0003-3494-8070; Kapczinski,
   Flavio/0000-0001-8738-856X; Pedrotti Moreira,
   Fernanda/0000-0002-3672-7231; Oses, Jean Pierre/0000-0002-2012-273X;
   Dias de Mattos Souza, Luciano/0000-0001-9965-4837; Magalhaes,
   Pedro/0000-0002-5644-6357
FU Coordenacao de Aperfeicoamento de pessoal de Ensino Superior (CAPES);
   Fundacao de Amparo a Pesquisa do Estado do Rio Grande do Sul (FAPERGS);
   Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
FX This study was supported by the following government agencies:
   Coordenacao de Aperfeicoamento de pessoal de Ensino Superior (CAPES),
   Fundacao de Amparo a Pesquisa do Estado do Rio Grande do Sul (FAPERGS)
   and Conselho Nacional de Desenvolvimento Cientifico e Tecnologico
   (CNPq).
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NR 42
TC 29
Z9 32
U1 0
U2 6
PU ASSOC BRASILEIRA PSIQUIATRIA
PI SAO PAULO
PA SUBSCRIPTION DEPARTMENT, RUA PEDRO DE TOLEDO, 967 - CASA 01, SAO PAULO,
   SP 04039-032  A, BRAZIL
SN 1516-4446
EI 1809-452X
J9 BRAZ J PSYCHIAT
JI Braz. J. Psychiat.
PD JAN-MAR
PY 2019
VL 41
IS 1
BP 38
EP 43
DI 10.1590/1516-4446-2017-2328
PG 6
WC Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychiatry
GA HK5QL
UT WOS:000458021800009
PM 30328961
OA Green Published, Green Submitted, gold
DA 2025-06-11
ER

PT J
AU Vázquez-Jiménez, JG
   Casillas-Armenta, OE
   Cortéz, MIO
   Romero-García, T
AF Vazquez-Jimenez, Jose Gustavo
   Casillas-Armenta, Oscar Eduardo
   Cortez, Mario Israel Oregel
   Romero-Garcia, Tatiana
TI Comprehending metabolic syndrome in children and adolescents:
   cardiometabolic outcomes in response to exercise
SO RETOS-NUEVAS TENDENCIAS EN EDUCACION FISICA DEPORTE Y RECREACION
LA English
DT Article
DE Children; adolescents; exercise; health; metabolic syndrome; obesity
ID INSULIN-RESISTANCE SYNDROME; OXIDATIVE STRESS; WEIGHT-LOSS; OBESITY;
   ASSOCIATION; DYSFUNCTION; TELEVISION; STRENGTH; HEALTH; MUSCLE
AB In recent years, the pandemic of obesity and metabolic syndrome (MetS) has gone from being a predominant problem in the adult population to becoming firmly established among children and adolescents. Precise data on the incidence and prevalence of MetS in children and adolescents are unreliable since the diagnosis is not guided by a standard definition adjusted to the characteristics of this population. A sedentary lifestyle has increased dramatically in the young population during the last years, where the influence of technology, high-calorie diets, and the lack of space, time, and interest in physical activity are the leading causes. Although various strategies must be implemented to counteract the increase in MetS cases in the young population, this review demonstrates the importance of physical exercise at a biochemical and physiological level as a critical prevention and treatment method, also presenting perspectives on how future research should be focused to acknowledge and cover this topic thoroughly.
C1 [Vazquez-Jimenez, Jose Gustavo; Casillas-Armenta, Oscar Eduardo; Cortez, Mario Israel Oregel; Romero-Garcia, Tatiana] Univ Autonoma Baja Calif, Mexicali, Mexico.
C3 Universidad Autonoma de Baja California
RP Romero-García, T (corresponding author), Univ Autonoma Baja Calif, Mexicali, Mexico.
EM gustavo.vazquez@uabc.edu.mx; casillas.oscar@uabc.edu.mx;
   mario.israel.oregel.cortez@uabc.edu.mx; tatiana.romero@uabc.edu.mx
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NR 68
TC 0
Z9 0
U1 1
U2 1
PU FEDERACION ESPANOLA ASOC DOCENTES EDUCACION FISICA-FEADEF
PI MURCIA
PA C CABO VIDIO 27, SAN JAVIER, MURCIA, 30730, SPAIN
SN 1579-1726
EI 1988-2041
J9 RETOS-NUEV TEND EDUC
JI Retos
PY 2025
IS 62
BP 122
EP 131
PG 10
WC Hospitality, Leisure, Sport & Tourism
WE Emerging Sources Citation Index (ESCI)
SC Social Sciences - Other Topics
GA K0Y2E
UT WOS:001341220600001
DA 2025-06-11
ER

PT J
AU Adan, RAH
   van der Beek, EM
   Buitelaar, JK
   Cryan, JF
   Hebebrand, J
   Higgs, S
   Schellekens, H
   Dickson, SL
AF Adan, Roger A. H.
   van der Beek, Eline M.
   Buitelaar, Jan K.
   Cryan, John F.
   Hebebrand, Johannes
   Higgs, Suzanne
   Schellekens, Harriet
   Dickson, Suzanne L.
TI Nutritional psychiatry: Towards improving mental health by what you eat
SO EUROPEAN NEUROPSYCHOPHARMACOLOGY
LA English
DT Review
DE Nutritional psychiatry; Nutrients; Cognition; Early life nutrition;
   Obesity; Dietary intervention
ID GUT-BRAIN AXIS; ATTENTION-DEFICIT/HYPERACTIVITY DISORDER;
   POLYUNSATURATED FATTY-ACIDS; MAJOR DEPRESSIVE DISORDER; MICROBIOTA
   COMPOSITION; FUNCTIONAL CONNECTIVITY; MEDITERRANEAN DIET; METABOLIC
   SYNDROME; COGNITIVE CONTROL; POSTNATAL-GROWTH
AB Does it matter what we eat for our mental health? Accumulating data suggests that this may indeed be the case and that diet and nutrition are not only critical for human physiology and body composition, but also have significant effects on mood and mental wellbeing. While the determining factors of mental health are complex, increasing evidence indicates a strong association between a poor diet and the exacerbation of mood disorders, including anxiety and depression, as well as other neuropsychiatric conditions. There are common beliefs about the health effects of certain foods that are not supported by solid evidence and the scientific evidence demonstrating the unequivocal link between nutrition and mental health is only beginning to emerge. Current epidemiological data on nutrition and mental health do not provide information about causality or underlying mechanisms. Future studies should focus on elucidating mechanism. Randomized controlled trials should be of high quality, adequately powered and geared towards the advancement of knowledge from population-based observations towards personalized nutrition. Here, we provide an overview of the emerging field of nutritional psychiatry, exploring the scientific evidence exemplifying the importance of a well-balanced diet for mental health. We conclude that an experimental medicine approach and a mechanistic understanding is required to provide solid evidence on which future policies on diet and nutrition for mental health can be based. (C) 2019 The Author(s). Published by Elsevier B.V.
C1 [Adan, Roger A. H.] Univ Med Ctr Utrecht, Dept Translat Neurosci, Univ Weg 100, NL-3584 CG Utrecht, Netherlands.
   [Adan, Roger A. H.; Dickson, Suzanne L.] Univ Gothenburg, Inst Neurosci & Physiol, Sahlgrenska Acad, Med Regatan 11, SE-40530 Gothenburg, Sweden.
   [van der Beek, Eline M.] Danone Nutricia Res, Utrecht, Netherlands.
   [van der Beek, Eline M.] Univ Med Ctr Groningen, Dept Pediat, Groningen, Netherlands.
   [Buitelaar, Jan K.] Radboud Univ Nijmegen, Dept Cognit Neurosci, Donders Inst Brain Cognit & Behav, Med Ctr, Nijmegen, Netherlands.
   [Buitelaar, Jan K.] Karakter Child & Adolescent Psychiat, Nijmegen, Netherlands.
   [Cryan, John F.; Schellekens, Harriet] Univ Coll Cork, Dept Anat & Neurosci, Cork, Ireland.
   [Cryan, John F.; Schellekens, Harriet] Univ Coll Cork, APC Microbiome Ireland, Cork, Ireland.
   [Hebebrand, Johannes] Univ Duisburg Essen, Dept Child & Adolescent Psychiat Psychosomat & Ps, Univ Hosp Essen, Essen, Germany.
   [Higgs, Suzanne] Univ Birmingham, Suzanne Higgs Sch Psychol, Birmingham, W Midlands, England.
C3 Utrecht University; Utrecht University Medical Center; University of
   Gothenburg; Danone Nutricia; University of Groningen; Radboud University
   Nijmegen; Radboud University Nijmegen; University College Cork;
   University College Cork; University of Duisburg Essen; University of
   Birmingham
RP Adan, RAH (corresponding author), Univ Med Ctr Utrecht, Dept Translat Neurosci, Univ Weg 100, NL-3584 CG Utrecht, Netherlands.; Dickson, SL (corresponding author), Univ Gothenburg, Inst Neurosci & Physiol, Sahlgrenska Acad, Med Regatan 11, SE-40530 Gothenburg, Sweden.
EM r.a.h.adan@umcutrecht.nl; suzanne.dickson@gu.se
RI Higgs, Suzanne/A-9632-2008; Dickson, Suzanne/U-4628-2019; Cryan,
   John/A-6950-2013; Buitelaar, Jan/AAY-7522-2020
OI Dickson, Suzanne/0000-0002-3822-5294; Schellekens,
   Harriet/0000-0002-6065-3797; Hebebrand, Johannes/0000-0001-5364-6073;
   Cryan, John/0000-0001-5887-2723; Higgs, Suzanne/0000-0002-9225-7692
FU European College for Neuropsychopharmacology (ECNP)
FX The European College for Neuropsychopharmacology (ECNP) for supporting
   the Nutrition Network. We would like to thank Dr. Ken O'Riordan, APC
   Microbiome Ireland, for the graphics of Fig. 1.
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NR 147
TC 222
Z9 245
U1 20
U2 110
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0924-977X
EI 1873-7862
J9 EUR NEUROPSYCHOPHARM
JI Eur. Neuropsychopharmacol.
PD DEC
PY 2019
VL 29
IS 12
BP 1321
EP 1332
DI 10.1016/j.euroneuro.2019.10.011
PG 12
WC Clinical Neurology; Neurosciences; Pharmacology & Pharmacy; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
GA JY3TV
UT WOS:000504342200003
PM 31735529
OA Green Published, hybrid
HC Y
HP N
DA 2025-06-11
ER

PT J
AU Nomura, K
   Nakao, M
   Tsurugano, S
   Takeuchi, T
   Inoue, M
   Shinozaki, Y
   Yano, E
AF Nomura, Kyoko
   Nakao, Mutsuhiro
   Tsurugano, Shinobu
   Takeuchi, Takeaki
   Inoue, Mariko
   Shinozaki, Yasuko
   Yano, Eiji
TI Job Stress and Healthy Behavior Among Male Japanese Office Workers
SO AMERICAN JOURNAL OF INDUSTRIAL MEDICINE
LA English
DT Article
DE healthy behavior; health promotion at workplace; job stress; lifestyle
   modification; Metabolic Syndrome
ID HONG-KONG CHINESE; CONSENSUS STATEMENT; DIABETES EDUCATION; OBESITY;
   WEIGHT; LOCUS; KNOWLEDGE; ADOLESCENTS; IMPROVEMENT; REDUCTION
AB Background Lifestyle modification in healthy workers is challenging. We aim to investigate associations between job stress and healthy behavior change among workers.
   Methods This cross-sectional study investigated 1,183 Japanese male white-collar workers in 2008 during health checkups for Metabolic Syndrome. Healthy behavior included either a calorie-focused diet or regular exercise. Job stress was measured by Job Content Questionnaire based on the job demands-control model and tension-anxiety and anger-hostility scales on the Profile of Mood States.
   Results Healthy behaviors were confirmed in 54% of study subjects. Multivariate logistic model showed that healthy behaviors were positively associated with a higher degree of work control and negatively associated with greater work demand. Work control and support were negatively correlated with tension-anxiety and depression, whereas work demand and strain were positively correlated with these two emotion domains (all P's < 0.0001).
   Conclusions It is suggested that addressing job stress is of clinical importance to promote healthy behaviors. Am. J. Ind. Med. 53:1128-1134, 2010. (c) 2010 Wiley-Liss, Inc.
C1 [Nomura, Kyoko] Teikyo Univ, Sch Med, Dept Hyg & Publ Hlth, Itabashi Ku, Tokyo 1738605, Japan.
C3 Teikyo University
RP Nomura, K (corresponding author), Teikyo Univ, Sch Med, Dept Hyg & Publ Hlth, Itabashi Ku, 2-11-1 Kaga, Tokyo 1738605, Japan.
EM kyoko@med.teikyo-u.ac.jp
FU Ministry of Education, Culture, Sports, Science & Technology of Japan
   [21590666]; Grants-in-Aid for Scientific Research [21590666] Funding
   Source: KAKEN
FX Contract grant sponsor: Ministry of Education, Culture, Sports, Science
   & Technology of Japan; Contract grant number: 21590666.
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Z9 22
U1 0
U2 32
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0271-3586
EI 1097-0274
J9 AM J IND MED
JI Am. J. Ind. Med.
PD NOV
PY 2010
VL 53
IS 11
BP 1128
EP 1134
DI 10.1002/ajim.20859
PG 7
WC Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Public, Environmental & Occupational Health
GA 672DQ
UT WOS:000283563600008
PM 20957727
DA 2025-06-11
ER

PT J
AU de Baca, TC
   Epel, ES
   Robles, TF
   Coccia, M
   Gilbert, A
   Puterman, E
   Prather, AA
AF de Baca, Tomas Cabeza
   Epel, Elissa S.
   Robles, Theodore F.
   Coccia, Michael
   Gilbert, Amanda
   Puterman, Eli
   Prather, Aric A.
TI Sexual intimacy in couples is associated with longer telomere length
SO PSYCHONEUROENDOCRINOLOGY
LA English
DT Article
DE Intimacy; Sexual relationships; Telomere length; Health; Couples
ID ENDOTHELIAL PROGENITOR CELLS; DYADIC ADJUSTMENT SCALE; OLDER-ADULTS;
   PSYCHOLOGICAL STRESS; METABOLIC SYNDROME; HEART-RATE; HEALTH; FREQUENCY;
   OXYTOCIN; WOMEN
AB High-quality relationships have been shown to be beneficial for physical and mental health. This study examined overall relationship satisfaction and perceived stress as well as daily reports of partner support, partner conflict, and physical intimacy obtained over the course of one week in a sample of 129 high and low stress mothers. Telomere length was examined in whole blood, as well as the two cell subpopulations: peripheral blood mononuclear cells (PBMCs) and granulocytes. Telomerase activity was measured in PBMCs. Analyses revealed no statistically significant associations of telomere length with current relationship satisfaction, daily support or conflict, or perceived stress. In contrast, women who reported any sexual intimacy during the course of the week had significantly longer telomeres measured in whole blood and PBMCs, but not in granulocytes. These relationships held covarying for age, body mass index, perceived stress, the relationship indices, and caregiver status. Sexual intimacy was not significantly related to PBMC telomerase activity. These data provide preliminary data that sexual intimacy is associated with longer telomere length. Future studies investigating these associations are warranted.
C1 [de Baca, Tomas Cabeza; Epel, Elissa S.; Coccia, Michael; Gilbert, Amanda; Prather, Aric A.] Univ Calif San Francisco, Dept Psychiat, 3333 Calif St Suite 465, San Francisco, CA 94118 USA.
   [Robles, Theodore F.] Univ Calif Los Angeles, Dept Psychol, Los Angeles, CA USA.
   [Puterman, Eli] Univ British Columbia, Sch Kinesiol, Vancouver, BC, Canada.
   [de Baca, Tomas Cabeza] Univ Calif San Francisco, Div Cardiol, San Francisco, CA 94143 USA.
C3 University of California System; University of California San Francisco;
   University of California System; University of California Los Angeles;
   University of British Columbia; University of California System;
   University of California San Francisco
RP de Baca, TC; Prather, AA (corresponding author), Univ Calif San Francisco, Dept Psychiat, 3333 Calif St Suite 465, San Francisco, CA 94118 USA.; de Baca, TC (corresponding author), Univ Calif San Francisco, Div Cardiol, San Francisco, CA 94143 USA.
EM tomas.cabezadebaca@ucsf.edu; aric.prather@ucsf.edu
RI Puterman, Eli/AAA-5237-2022; Robles, Theodore/MZS-2465-2025; Epel,
   Elissa/ABI-6703-2022
OI Puterman, Eli/0000-0002-5898-2348
FU National Institute of Mental Health [T32MH019391]; NIH [AG030424,
   HL117727, HL112961]; National Institute of Mental Health [T32MH019391]
   Funding Source: NIH RePORTER
FX TCDB was supported by a National Institute of Mental Health
   grantT32MH019391. Support for this study was provided by NIH
   grantsAG030424 (ESE), HL117727 (ESE), and HL112961 (AAP).
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NR 55
TC 12
Z9 15
U1 3
U2 15
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4530
J9 PSYCHONEUROENDOCRINO
JI Psychoneuroendocrinology
PD JUL
PY 2017
VL 81
BP 46
EP 51
DI 10.1016/j.psyneuen.2017.03.022
PG 6
WC Endocrinology & Metabolism; Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism; Neurosciences & Neurology; Psychiatry
GA EZ6GA
UT WOS:000404815200007
PM 28411413
OA Green Accepted, Green Submitted
DA 2025-06-11
ER

PT J
AU Eudave, DM
   BeLow, MN
   Flandreau, EI
AF Eudave, Deseree M.
   BeLow, McKenna N.
   Flandreau, Elizabeth, I
TI Effects of high fat or high sucrose diet on behavioral-response to
   social defeat stress in mice
SO NEUROBIOLOGY OF STRESS
LA English
DT Article
DE Social defeat stress; High fat diet; High sucrose diet; Negative valence
ID FOOD-INTAKE; ANXIETY; DEPRESSION; EXPOSURE; WEIGHT; MOOD; RATS
AB Stress increases risk for psychopathology, and diet may moderate the impact of stress on mental health. A "Western" diet has been linked to psychopathology in humans; animal studies also show that diet can influence negative valence behavior in the presence or absence of stress, but findings are inconsistent. Contradictions in existing studies may result from differences in macronutrient content of diets and presence of metabolic syndrome. The present study exposed mice to 10 days of high fat or high sucrose diet concurrent with social defeat stress exposure and examined negative valence behavior at acute ( < five days) and long-term ( > 30 days) time points after stress/diet exposure. Predictably, stress increased negative valence behavior in the social interaction, open field, elevated zero maze, and tail suspension tests at the acute time point. While most stress-induced behaviors normalized after the 30-day recovery period, social avoidance was still highly significant for stress-exposed mice, supporting the hypothesis that avoidance of a trauma-related cue persists beyond non-specific anxiety-like behaviors. Supporting the hypothesis that an unhealthy diet contributes to psychopathology, non-stressed mice fed high fat or high sucrose diets spent less time exploring the center of the open field. This effect was no longer present after a 30-day recovery. Intriguingly, mice previously fed either high fat or high sucrose diets exhibited increased rearing behavior in the elevated zero maze 30 days post stress and diet exposure. This finding could be evidence that short-term diet administration can initiate a long-term increase in risk-assessment behavior.
C1 [Eudave, Deseree M.; BeLow, McKenna N.; Flandreau, Elizabeth, I] Grand Valley State Univ, 1 Campus Dr, Allendale, MI 49401 USA.
   [Eudave, Deseree M.] 143 Valley Ave NW, Grand Rapids, MI 49504 USA.
   [BeLow, McKenna N.] 23500 Edgewood Rd NE 103, Cedar Rapids, IA 52402 USA.
C3 Grand Valley State University
RP Flandreau, EI (corresponding author), Grand Valley State Univ, 1 Campus Dr, Allendale, MI 49401 USA.
EM desieudave@gmail.com; Mckenna.below@gmail.com; flandree@gvsu.edu
OI Flandreau, Elizabeth/0000-0003-3634-1694
FU GVSU Catalyst; GVSU McNair; GVSU Psychology Department
FX GVSU Catalyst.GVSU McNair.GVSU Psychology Department.
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NR 36
TC 27
Z9 27
U1 2
U2 16
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 2352-2895
J9 NEUROBIOL STRESS
JI Neurobiol. Stress
PD NOV
PY 2018
VL 9
BP 1
EP 8
DI 10.1016/j.ynstr.2018.05.005
PG 8
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA GZ9CN
UT WOS:000449794300001
PM 30003122
OA gold, Green Published
DA 2025-06-11
ER

PT J
AU Osali, A
   Rostami, A
AF Osali, Ali
   Rostami, Alireza
TI Effect of 6 weeks of aerobic training with nanocurcumin consumption on
   IL1β, nitric oxide, and depression in women with metabolic syndrome
SO INTERNATIONAL JOURNAL OF DIABETES IN DEVELOPING COUNTRIES
LA English
DT Article
DE Aerobic exercise; Inflammation; Depression; Metabolic syndrome;
   Nanocurcumin
ID AMINO-ACIDS; CURCUMIN; SEROTONIN; SYMPTOMS; EXERCISE; DEMENTIA
AB Backgrounds and ObjectivesThe use of anti-inflammatory supplements is important in improving the executive function of obese people. This research aims to investigate the effect of 6 weeks of aerobic exercise with moderate intensity as well as the consumption of nanocurcumin on IL1 beta, nitric oxide (NO), and depression in women aged 60-65 with metabolic syndrome.Materials and MethodsFourty-four women with metabolic syndrome were randomly selected and divided into four groups of 10 based on their use of nanocurcumin supplement. The treatment included the training (T), nanocurcumin (N), training + nanocurcumin (TN), and the control groups. The groups exposed to training performed aerobic exercise for 6 weeks (three sessions per week). Blood samples were obtained before and after the training period for antioxidant indicators and lipid degradation measurement. Also, the Beck anxiety questionnaire was used for evaluating levels of anxiety. T-test and one-way analysis of variance (ANOVA) tests were used for the assessment of within-group and between-group differences, respectively.ResultsThere was a significant difference in IL1 beta, NO, and depression before and after exercise in all three experimental groups (p <= 0.05). Also, the results showed a significant difference in the level of NO and depression in the experimental groups. The highest decrease in these variables was observed in the T and TN groups (p <= 0.05).ConclusionThese findings indicated that 6-week nanocurcumin supplementation with aerobic training is a suitable method for reducing IL1 beta, NO, and depression, preventing metabolic, cardiovascular, and inflammatory diseases in women with metabolic syndrome.Name of the registry: IR.SEMUMS.REC.1396.107Trial registration number: IRCT2017082335857N1
C1 [Osali, Ali; Rostami, Alireza] Univ Bonab, Dept Gen Courses Exercise Physiol Phys Educ & Spor, Bonab, Iran.
C3 University of Bonab
RP Osali, A (corresponding author), Univ Bonab, Dept Gen Courses Exercise Physiol Phys Educ & Spor, Bonab, Iran.
EM osaliphd@ubonab.ac.ir
FU University of Bonab, Iran [97/I/ER/1920]
FX This article is taken from research project number 97/I/ER/1920,
   sponsored by the University of Bonab, Iran.
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NR 31
TC 3
Z9 3
U1 2
U2 7
PU SPRINGER INDIA
PI NEW DELHI
PA 7TH FLOOR, VIJAYA BUILDING, 17, BARAKHAMBA ROAD, NEW DELHI, 110 001,
   INDIA
SN 0973-3930
EI 1998-3832
J9 INT J DIABETES DEV C
JI Int. Diabetes Dev. Ctries.
PD DEC
PY 2023
VL 43
IS 6
BP 1007
EP 1014
DI 10.1007/s13410-023-01168-6
EA FEB 2023
PG 8
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA U7TH6
UT WOS:000924071800001
DA 2025-06-11
ER

PT J
AU Guessous, I
   Bonny, O
   Paccaud, F
   Mooser, V
   Waeber, G
   Vollenweider, P
   Bochud, M
AF Guessous, Idris
   Bonny, Olivier
   Paccaud, Fred
   Mooser, Vincent
   Waeber, Gerard
   Vollenweider, Peter
   Bochud, Murielle
TI Serum Calcium Levels Are Associated with Novel Cardiometabolic Risk
   Factors in the Population-Based CoLaus Study
SO PLOS ONE
LA English
DT Article
ID GAMMA-GLUTAMYL-TRANSFERASE; CARDIOVASCULAR-DISEASE MORTALITY;
   BONE-MINERAL DENSITY; MIDDLE-AGED MEN; METABOLIC SYNDROME; URIC-ACID;
   INSULIN-RESISTANCE; PRIMARY HYPERPARATHYROIDISM; OXIDATIVE STRESS;
   HEART-DISEASE
AB Background: Associations of serum calcium levels with the metabolic syndrome and other novel cardio-metabolic risk factors not classically included in the metabolic syndrome, such as those involved in oxidative stress, are largely unexplored. We analyzed the association of albumin-corrected serum calcium levels with conventional and non-conventional cardio-metabolic risk factors in a general adult population.
   Methodology/Principal Findings: The CoLaus study is a population-based study including Caucasians from Lausanne, Switzerland. The metabolic syndrome was defined using the Adult Treatment Panel III criteria. Non-conventional cardio-metabolic risk factors considered included: fat mass, leptin, LDL particle size, apolipoprotein B, fasting insulin, adiponectin, ultrasensitive CRP, serum uric acid, homocysteine, and gamma-glutamyltransferase. We used adjusted standardized multivariable regression to compare the association of each cardio-metabolic risk factor with albumin-corrected serum calcium. We assessed associations of albumin-corrected serum calcium with the cumulative number of non-conventional cardio-metabolic risk factors. We analyzed 4,231 subjects aged 35 to 75 years. Corrected serum calcium increased with both the number of the metabolic syndrome components and the number of non-conventional cardio-metabolic risk factors, independently of the metabolic syndrome and BMI. Among conventional and non-conventional cardio-metabolic risk factors, the strongest positive associations were found for factors related to oxidative stress (uric acid, homocysteine and gamma-glutamyltransferase). Adiponectin had the strongest negative association with corrected serum calcium.
   Conclusions/Significance: Serum calcium was associated with the metabolic syndrome and with non-conventional cardio-metabolic risk factors independently of the metabolic syndrome. Associations with uric acid, homocysteine and gammaglutamyltransferase were the strongest. These novel findings suggest that serum calcium levels may be associated with cardiovascular risk via oxidative stress.
C1 [Guessous, Idris; Paccaud, Fred; Bochud, Murielle] Univ Lausanne, Inst Social & Prevent Med, Community Prevent Unit, Ctr Hosp Univ Vaudois, CH-1000 Lausanne, Switzerland.
   [Guessous, Idris] Univ Hosp Geneva, Dept Community Med Primary Care & Emergency Med, Div Primary Care Med, Unit Populat Epidemiol, Geneva, Switzerland.
   [Bonny, Olivier] Univ Lausanne Hosp, Serv Nephrol & Hypertens, Lausanne, Switzerland.
   [Bonny, Olivier] Univ Lausanne, Dept Pharmacol & Toxicol, Lausanne, Switzerland.
   GlaxoSmithKline Res & Dev Ltd, Div Genet, King Of Prussia, PA USA.
   [Waeber, Gerard; Vollenweider, Peter] CHU Vaudois, Dept Med, Lausanne, Switzerland.
C3 University of Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV);
   Swiss School of Public Health (SSPH+); University of Geneva; University
   of Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV); University
   of Lausanne; GlaxoSmithKline; Glaxosmithkline USA; University of
   Lausanne; Centre Hospitalier Universitaire Vaudois (CHUV)
RP Guessous, I (corresponding author), Univ Lausanne, Inst Social & Prevent Med, Community Prevent Unit, Ctr Hosp Univ Vaudois, CH-1000 Lausanne, Switzerland.
EM Idris.Guessous@chuv.ch
RI ; Vollenweider, Peter/Q-4603-2016
OI bonny, olivier/0000-0003-4123-4279; Waeber, Gerard/0000-0003-4193-788X;
   Vollenweider, Peter/0000-0002-0765-896X
FU GlaxoSmithKline (GSK); Swiss National Science Foundation [33CSCO-122661,
   SNF 33CM30-124087/1]
FX The CoLaus study was sponsored in part by GlaxoSmithKline (GSK), and
   currently by the Swiss National Science Foundation (33CSCO-122661). IG
   is supported by a Swiss National Science Foundation grant (SNF
   33CM30-124087/1). These funders had no role in study design, data
   collection and analysis, decision to publish, or preparation of the
   manuscript. VM is a full-time employee of GSK and played a role in study
   design, data collection and analysis, decision to publish and
   preparation of the manuscript.
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NR 47
TC 15
Z9 16
U1 0
U2 1
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 185 BERRY ST, STE 1300, SAN FRANCISCO, CA 94107 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD APR 21
PY 2011
VL 6
IS 4
AR e18865
DI 10.1371/journal.pone.0018865
PG 9
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 756ME
UT WOS:000290014500015
PM 21533040
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Akbaraly, TN
   Kivimäki, M
   Brunner, EJ
   Chandola, T
   Marmot, MG
   Singh-Manoux, A
   Ferrie, JE
AF Akbaraly, Tasnime N.
   Kivimaeki, Mika
   Brunner, Eric J.
   Chandola, Tarani
   Marmot, Michael G.
   Singh-Manoux, Archana
   Ferrie, Jane E.
TI Association Between Metabolic Syndrome and Depressive Symptoms in
   Middle-Aged Adults Results from the Whitehall II study
SO DIABETES CARE
LA English
DT Article
ID YOUNG-ADULTS; RISK; HEALTH; MORTALITY; ANXIETY; OBESITY; DISEASE; WOMEN
AB OBJECTIVE - Although it is possible that the association between depression and the metabolic syndrome is a "two-way street," the metabolic syndrome as a predictor of depression has been little investigated. We examined whether the metabolic syndrome is associated with the onset of depressive symptoms in a cohort of middle-aged British civil servants.
   RESEARCH DESIGN AND METHODS - Analyses included 5,232, participants (41-61 years of age) from the Whitehall II prospective cohort study. Depressive symptoms were assessed in 1991-1993 and again 6 years later using the depression subscale from the 30-item General Health Questionnaire. Metabolic syndrome was assessed in 1991-1993, according to National Cholesterol Education Program criteria.
   RESULTS- Presence of the metabolic syndrome was associated With an increased risk of future depressive symptoms, odds ratio 1.38 (95% CI 1.02 -1.96) after adjustment for potential confounders. Of the five components, only central obesity, high triglyceride levels, and low HDL cholesterol levels predicted depressive symptoms, These components explained most of the association between the metabolic syndrome and the onset of depressive symptoms.
   CONCLUSIONS- Our results Suggest that the Metabolic syndrome, in particular the obesity and dyslipidemia components, is predictive of depressive symptoms.
C1 [Akbaraly, Tasnime N.; Kivimaeki, Mika; Brunner, Eric J.; Chandola, Tarani; Marmot, Michael G.; Singh-Manoux, Archana; Ferrie, Jane E.] UCL, Dept Epidemiol & Publ Hlth, London W1N 8AA, England.
   [Singh-Manoux, Archana] Inst Natl Sante & Rech Med, Unite 687, IFR69, Villejuif, France.
   [Singh-Manoux, Archana] Hop Ste Perine, AP HP, Ctr Gerontol, Paris, France.
C3 University of London; University College London; Institut National de la
   Sante et de la Recherche Medicale (Inserm); Hopital Universitaire
   Sainte-Perine - APHP; Assistance Publique Hopitaux Paris (APHP)
RP Akbaraly, TN (corresponding author), UCL, Dept Epidemiol & Publ Hlth, Mortimer St, London W1N 8AA, England.
EM t.akbaraly@ucl.ac.uk
RI Kivimaki, Mika/B-3607-2012; Brunner, Eric/H-2114-2011; Ferrie,
   Jane/AAZ-2009-2020; Akbaraly, Tasnime/H-1389-2018; Singh-Manoux,
   Archana/F-6804-2013; Chandola, Tarani/I-3192-2013; Marmot,
   Michael/Y-3920-2019
OI Akbaraly, Tasnime/0000-0002-2150-4190; Singh-Manoux,
   Archana/0000-0002-1244-5037; Chandola, Tarani/0000-0002-1864-3413;
   Marmot, Michael/0000-0002-2431-6419; Kivimaki, Mika/0000-0002-4699-5627;
   Brunner, Eric/0000-0002-0595-4474
FU Academy of Finland [117004, 124322, 124271]; European Science
   Foundation; Medical Research Council (MRC); MRC [G8802774]; British MRC;
   British Heart Foundation; British Health and Safety Executive; British
   Department of Health; National Heart, Lung, and Blood Institute
   [HL36310]; National Institute on Aging [AG13196]; Agency for Health Care
   Policy and Research [HS06516]; John D. and Catherine T. MacArthur
   Foundation Research Networks on Successful Midlife Development and
   Socioeconomic Status and Health
FX M.K. is supported by the Academy of Finland (projects 117004, 124322,
   and 124271). A.S.-M. is supported by a European Young Investigator Award
   from the European Science Foundation. M.M. is supported by a Medical
   Research Council (MRC) research professorship. J.F.F, is supported by
   the MRC (grant G8802774). The Whitehall II study has been supported by
   grants from the British MRC; the British Heart Foundation; the British
   Health and Safety Executive; the British Department of Health; the
   National Heart, Lung, and Blood Institute (Grant HL36310); the National
   Institute on Aging (Grant AG13196); the Agency for Health Care Policy
   and Research (Grant HS06516); and the John D. and Catherine T. MacArthur
   Foundation Research Networks on Successful Midlife Development and
   Socioeconomic Status and Health. No potential conflicts of interest
   relevant to this article were reported. We thank all of the
   participating civil service departments and their welfare, personnel,
   and establishment officers; the British Occupational Health and Safety
   Agency; the British Council of Civil Service Unions; all participating
   civil servants in the Whitehall II study and all members of the
   Whitehall II study team.
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NR 25
TC 117
Z9 135
U1 0
U2 6
PU AMER DIABETES ASSOC
PI ALEXANDRIA
PA 1701 N BEAUREGARD ST, ALEXANDRIA, VA 22311-1717 USA
SN 0149-5992
EI 1935-5548
J9 DIABETES CARE
JI Diabetes Care
PD MAR
PY 2009
VL 32
IS 3
BP 499
EP 504
DI 10.2337/dc08-1358
PG 6
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Endocrinology & Metabolism
GA 417EX
UT WOS:000264060400025
PM 19106378
OA Green Submitted, Green Published, Green Accepted, hybrid
DA 2025-06-11
ER

PT J
AU Labarthe, A
   Fiquet, O
   Hassouna, R
   Zizzari, P
   Lanfumey, L
   Ramoz, N
   Grouselle, D
   Epelbaum, J
   Tolle, V
AF Labarthe, Alexandra
   Fiquet, Oriane
   Hassouna, Rim
   Zizzari, Philippe
   Lanfumey, Laurence
   Ramoz, Nicolas
   Grouselle, Dominique
   Epelbaum, Jacques
   Tolle, Virginie
TI Ghrelin-derived peptides: a link between appetite/reward, GH axis, and
   psychiatric disorders?
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Review
DE ghrelin; eating disorders; food reward; alcohol and drug addiction;
   anxiety; depression; growth hormone
ID HORMONE SECRETAGOGUE RECEPTOR; ALCOHOL-DEPENDENT PATIENTS; PLASMA
   ACYLATED GHRELIN; GROWTH-HORMONE; CIRCULATING GHRELIN; FOOD-INTAKE;
   INSULIN SENSITIVITY; ANOREXIA-NERVOSA; BEHAVIORAL-RESPONSES; DEPRESSIVE
   DISORDER
AB Psychiatric disorders are often associated with metabolic and hormonal alterations, including obesity, diabetes, metabolic syndrome as well as modifications in several biological rhythms including appetite, stress, sleep wake cycles, and secretion of their corresponding endocrine regulators. Among the gastrointestinal hormones that regulate appetite and adapt the metabolism in response to nutritional, hedonic, and emotional dysfunctions, at the interface between endocrine, metabolic, and psychiatric disorders, ghrelin plays a unique role as the only one increasing appetite. The secretion of ghrelin is altered in several psychiatric disorders (anorexia, schizophrenia) as well as in metabolic disorders (obesity) and in animal models in response to emotional triggers (psychological stress...) but the relationship between these modifications and the physiopathology of psychiatric disorders remains unclear. Recently, a large literature showed that this key metabolic/endocrine regulator is involved in stress and reward-oriented behaviors and regulates anxiety and mood. In addition, preproghrelin is a complex prohormone but the roles of the other ghrelin-derived peptides, thought to act as functional ghrelin antagonists, are largely unknown. Altered ghrelin secretion and/or signaling in psychiatric diseases are thought to participate in altered appetite, hedonic response and reward. Whether this can contribute to the mechanism responsible for the development of the disease or can help to minimize some symptoms associated with these psychiatric disorders is discussed in the present review. We will thus describe (1) the biological actions of ghrelin and ghrelin-derived peptides on food and drugs reward, anxiety and depression, and the physiological consequences of ghrelin invalidation on these parameters, (2) how ghrelin and ghrelin-derived peptides are regulated in animal models of psychiatric diseases and in human psychiatric disorders in relation with the GH axis.
C1 [Labarthe, Alexandra; Fiquet, Oriane; Hassouna, Rim; Zizzari, Philippe; Lanfumey, Laurence; Ramoz, Nicolas; Grouselle, Dominique; Epelbaum, Jacques; Tolle, Virginie] Univ Paris 05, INSERM, Ctr Psychiat & Neurosci, UMR S 894, 2 Ter Rue Alesia, F-75014 Paris, France.
C3 Universite Paris Cite; Institut National de la Sante et de la Recherche
   Medicale (Inserm)
RP Tolle, V (corresponding author), Univ Paris 05, INSERM, Ctr Psychiat & Neurosci, UMR S 894, 2 Ter Rue Alesia, F-75014 Paris, France.
EM virginie.tolle@inserm.fr
RI Hassouna, Rim/AAS-5664-2021; Lanfumey, Laurence/P-3037-2017; Epelbaum,
   Jacques/B-2263-2013; Tolle, Virginie/H-5264-2015; ramoz,
   nicolas/K-3316-2015
OI Zizzari, Philippe/0000-0001-8838-0762; ramoz,
   nicolas/0000-0002-8070-9938
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NR 151
TC 56
Z9 61
U1 0
U2 26
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PY 2014
VL 5
AR 163
DI 10.3389/fendo.2014.00163
PG 19
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA V44LF
UT WOS:000209749800161
PM 25386163
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Saeed, AK
   Al-Dabbagh, TQ
AF Saeed, AK
   Al-Dabbagh, TQ
TI Type 2 diabetes and its association with hypertension and depression in
   an Iraqi population
SO ANNALS OF SAUDI MEDICINE
LA English
DT Article
DE type 2 diabetes mellitus; arterial hypertension; metabolic syndrome;
   depression
ID METABOLIC SYNDROME; MAJOR DEPRESSION; MELLITUS; RISK; SYMPTOMATOLOGY;
   SYMPTOMS; ANXIETY
AB Background: The association of type 2 diabetes mellitus and hypertension is so high that it cannot be explained on the basis of diabetic nephropathy. This phenomenon has been attributed to a condition known as metabolic syndrome. Depression may be another aspect of metabolic syndrome.
   Patients and Methods: We conducted a cross-sectional case-control study with 110 patients with type 2 diabetes mellitus (DM) and 110 control subjects of comparable age and sex. We determined the time since diagnosis of diabetes, the presence of hypertension (HT), coronary heart disease, cerebrovascular insufficiency, and depression, and took several anthropometric measurements, including height, weight, body mass index (BMI) waist circumference (WC), waist-to-hip circumference ratio (WHR), triceps skin fold thickness (TSFT), mid-upper arm circumference (MUAC), and mid-upper arm muscle area (MAMA). We also investigated depression in metabolic syndrome by comparing patients with type 2 diabetes alone and with type 2 diabetes and hypertension who attended a diabetes clinic.
   Results: The prevalence of depression in hypertensive diabetics was 57% whereas in diabetics alone it was 40% (chi(2)=4.3, P<0.05). Likewise, combined hypertension and depression was more common among diabetics than controls (66% vs 25% respectively P<0.01).
   Conclusion: The presence of combined hypertension and type 2 diabetes should alert the clinician to look for other features of the metabolic syndrome and for associated depression, which should be treated in most cases by pharmacotherapy.
C1 Univ Mosul, Coll Med, Mosul, Iraq.
C3 University of Mosul
RP Univ Mosul, Coll Med, Mosul, Iraq.
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NR 47
TC 9
Z9 10
U1 0
U2 2
PU K FAISAL SPEC HOSP RES CENTRE
PI RIYADH
PA PUBLICATIONS OFFICE PO BOX 3354, RIYADH 11211, SAUDI ARABIA
SN 0256-4947
EI 1319-9226
J9 ANN SAUDI MED
JI Ann. Saudi Med.
PD SEP-OCT
PY 2003
VL 23
IS 5
BP 254
EP 259
DI 10.5144/0256-4947.2003.254
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA 727DN
UT WOS:000185641600003
PM 16868390
DA 2025-06-11
ER

PT J
AU Gheshlagh, RG
   Parizad, N
   Sayehmiri, K
AF Gheshlagh, Reza Ghanei
   Parizad, Naser
   Sayehmiri, Kourosh
TI The Relationship Between Depression and Metabolic Syndrome: Systematic
   Review and Meta-Analysis Study
SO IRANIAN RED CRESCENT MEDICAL JOURNAL
LA English
DT Review
DE Meta-Analysis; Depression; Metabolic Syndrome
ID MAJOR DEPRESSION; NATIONAL-HEALTH; YOUNG-ADULTS; ASSOCIATION; RISK;
   SYMPTOMS; ANXIETY; DISEASE
AB Context: Several studies have been conducted on the relationship between depression and metabolic syndrome, which have had conflicting results. The purpose of this study was a meta-analysis of studies that have examined the relationship between these two variables.
   Evidence Acquisition: This meta-analysis systematically reviewed the relationship between depression and metabolic syndrome. Scientific databases including IranMedex, SID, Magiran, Scopus, PubMed, Google Scholar, and Science Direct were searched and 17 articles were extracted from 2000 to 2014. Selected studies data were analyzed using meta-analysis and random effects model. Heterogeneity between the studies was examined using I2. Data were analyzed using STATA software version 12.1.
   Results: Seventeen studies were analyzed with a sample size of 31880 people. Analysis by the type of studies showed that the relationship between the two variables in cross-sectional studies (OR = 1.51, CI 95% = 1.36-1.68) and cohort studies (OR = 1.6, CI 95% = 1.23 -2.08) was significant. In general, the heterogeneity test results among the studies was not significant (P for heterogeneity = 0.08, I-2 = 39.8%).
   Conclusions: There is a relationship between depression and metabolic syndrome.
C1 [Gheshlagh, Reza Ghanei] Kurdistan Univ Med Sci, Nursing, Sanandaj, Iran.
   [Parizad, Naser] Tabriz Univ Med Sci, Dept Nursing, Fac Nursing & Midwifery, Tabriz, Iran.
   [Sayehmiri, Kourosh] Ilam Univ Med Sci, Dept Biostat, Prevent Psychosocial Injuries Res Ctr, Ilam, Iran.
C3 Kurdistan University of Medical Sciences; Tabriz University of Medical
   Science
RP Sayehmiri, K (corresponding author), Ilam Univ Med Sci, Dept Biostat, Prevent Psychosocial Injuries Res Ctr, Ilam, Iran.
EM Sayehmiri@razi.ac.ir
RI Parizad, Naser/U-8437-2019; Sayehmiri, Kourosh/IVV-7203-2023; Ghanei
   Gheshlagh, Reza/S-7043-2017; Sayehmiri, Kourosh/M-8924-2015
OI Ghanei Gheshlagh, Reza/0000-0002-7414-8134; Sayehmiri,
   Kourosh/0000-0002-9742-770X; Parizad, Naser/0000-0001-7393-3010
FU Ilam University of Medical Sciences and proteomics research center
   (Shahid Beheshti University of Medical Sciences)
FX This study was supported by a grant from deputies for research of Ilam
   University of Medical Sciences and proteomics research center (Shahid
   Beheshti University of Medical Sciences).
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NR 31
TC 89
Z9 92
U1 0
U2 15
PU KOWSAR PUBL
PI HOENSBROEK
PA PATERSWEG 22,, HOENSBROEK, LIMBURG 6431 GC, NETHERLANDS
SN 2074-1804
EI 2074-1812
J9 IRAN RED CRESCENT ME
JI Iran. Red Crescent Med. J.
PD JUN
PY 2016
VL 18
IS 6
AR e26523
DI 10.5812/ircmj.26523
PG 6
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA EA2UO
UT WOS:000386451000004
PM 27621928
OA Green Submitted, Green Published
DA 2025-06-11
ER

PT J
AU Jadhav, ST
   Ferrell, WR
   Petrie, JR
   Scherbakova, O
   Greer, IA
   Cobbe, SM
   Sattar, N
AF Jadhav, ST
   Ferrell, WR
   Petrie, JR
   Scherbakova, O
   Greer, IA
   Cobbe, SM
   Sattar, N
TI Microvascular function, metabolic syndrome, and novel risk factor status
   in women with cardiac syndrome X
SO AMERICAN JOURNAL OF CARDIOLOGY
LA English
DT Article
ID ENDOTHELIAL DYSFUNCTION; INSULIN-RESISTANCE; ANGINA; HYPERINSULINEMIA;
   DISEASE; ACETYLCHOLINE; PREECLAMPSIA; RESPONSES
AB To characterize microvascular function, candidate risk pathways, and metabolic syndrome prevalence in women with cardiac syndrome X, 52 nondiabetic women with angiographically normal epicardial arteries but > 1 mm of planar ST depression during exercise testing patients) and 24 healthy controls of similar age were recruited. In addition to fasting blood samples and anthropometric measurements, forearm cutaneous microvascular function after iontophoresis of acetylcholine and sodium nitroprusside was assessed by laser Doppler imaging. Despite body mass index correction and a larger proportion on statin therapy, patients had high levels of insulin (p = 0.016), triglycerides (p = 0.018), intercellular adhesion molecule-1 (p = 0.021), von Willebrand factor (p = 0.005), and leptin (p = 0.005) and lower levels of high-density lipoprotein cholesterol (p = 0.042) compared with controls. Consistent with these data, 30% of patients but only 8% of controls fulfilled criteria for the metabolic syndrome as defined by the National Cholesterol Education Program (p = 0.015). Endothelium-dependent and -independent microvascular functions were markedly impaired in patients (p < 0.001), and the odds ratio for cardiac syndrome X was 7.38 (95% confidence interval 2.2 to 24.7) if the acetylcholine response was < 8,710 flux units. In conclusion, women with cardiac syndrome X more commonly have metabolic syndrome and related adiposity, metabolic, and inflammatory derangements. They also have significantly impaired skin microvascular function as assessed by laser Doppler imaging, consistent with generalized vascular dysfunction, a finding with potential diagnostic implications. (c) 2006 Elsevier Inc. All rights reserved.
C1 Royal Infirm, Glasgow G31 2ER, Lanark, Scotland.
C3 Royal Infirmary of Edinburgh
RP Jadhav, ST (corresponding author), Royal Infirm, Glasgow G31 2ER, Lanark, Scotland.
EM stjadhav@bigfoot.com
RI Sattar, Naveed/AFN-0504-2022; Petrie, James/D-4598-2009
OI Petrie, John/0000-0002-4894-9819
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NR 19
TC 38
Z9 39
U1 0
U2 14
PU EXCERPTA MEDICA INC
PI NEW YORK
PA 650 AVENUE OF THE AMERICAS, NEW YORK, NY 10011 USA
SN 0002-9149
J9 AM J CARDIOL
JI Am. J. Cardiol.
PD JUN 15
PY 2006
VL 97
IS 12
BP 1727
EP 1731
DI 10.1016/j.amjcard.2005.12.069
PG 5
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 055EZ
UT WOS:000238434100010
PM 16765122
DA 2025-06-11
ER

PT J
AU Wolkowitz, OM
   Epel, ES
   Reus, VI
   Mellon, SH
AF Wolkowitz, Owen M.
   Epel, Elissa S.
   Reus, Victor I.
   Mellon, Synthia H.
TI DEPRESSION GETS OLD FAST: DO STRESS AND DEPRESSION ACCELERATE CELL
   AGING?
SO DEPRESSION AND ANXIETY
LA English
DT Review
DE depression; stress; aging; cortisol; BDNF; DHEA; telomeres; oxidation;
   inflammation; allopregnanolone
ID SEROTONIN REUPTAKE INHIBITORS; PRO-INFLAMMATORY CYTOKINES; UNIPOLAR
   MAJOR DEPRESSION; INDUCED OXIDATIVE STRESS; GLUCOCORTICOID-RECEPTOR;
   NEUROTROPHIC FACTOR; CARDIOVASCULAR-DISEASE; TELOMERE LENGTH;
   NEUROACTIVE STEROIDS; HIPPOCAMPAL NEUROGENESIS
AB Depression has been likened to a state of "accelerated aging," and depressed individuals have a higher incidence of various diseases of aging, such as cardiovascular and cerebro vascular diseases, metabolic syndrome, and dementia. Chronic exposure to certain interlinked biochemical pathways that mediate stress-related depression may contribute to "accelerated aging," cell damage, and certain comorbid medical illnesses. Biochemical mediatory explored in this theoretical review include the hypothalamic-pituitary-adrenal axis (e.g., hyperor hypoactivation of glucocorticoid receptors), neurosteroids, such as dehydroepiandrosterone and allopregnanolone, brain-derived neurotrophic factor excitotoxicity, oxidative and inflammatory stress, and disturbances of the telomere/telomerase maintenance system. A better appreciation of the role of these mediators in depressive illness could lead to refined models of depression, to a re-conceptualization of depression as a whole body disease rather than just a "mental illness," and to the rational development of new classes of medications to treat depression and its related medical comorbidities. Depression and Anxiety 27:327-338, 2010. (C) 2010 Wiley-Liss, Inc.
C1 [Wolkowitz, Owen M.; Epel, Elissa S.; Reus, Victor I.] Univ Calif San Francisco, Sch Med, Dept Psychiat, San Francisco, CA 94143 USA.
   [Mellon, Synthia H.] Univ Calif San Francisco, Sch Med, Dept OB GYN & Reprod Sci, San Francisco, CA USA.
C3 University of California System; University of California San Francisco;
   University of California System; University of California San Francisco
RP Wolkowitz, OM (corresponding author), 401 Parnassus Ave,Box F-0984, San Francisco, CA 94143 USA.
EM Owen.Wolkowitz@ucsf.edu
RI Epel, Elissa/ABI-6703-2022; Wolkowitz, Owen/J-6649-2013; reus,
   victor/I-7923-2015
OI reus, victor/0000-0002-8193-5697
FU O'Shaughnessy Foundation; University of California, San Francisco,
   Academic Senate; Jazz Pharmaceuticals; Merck Pharmaceuticals
FX The authors acknowledge the generosity of the O'Shaughnessy Foundation,
   which supplied major funding. Additional funding was supplied by the
   University of California, San Francisco, Academic Senate. The authors
   are also grateful to Dr. Jue Lin, who has provided expert advice and
   technical aid in the field of cell aging and Dr. Elizabeth Blackburn, a
   pioneer in the field of cell aging, whose guidance has been
   indispensible.Financial disclosures: Dr. Wolkowitz has received lecture
   honoraria from Jazz Pharmaceuticals and Merck Pharmaceuticals, and has
   served on an Advisory Board for Pfizer Pharmaceuticals. No other authors
   have financial ties to these or any other pharmaceutical companies.
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NR 214
TC 227
Z9 244
U1 1
U2 60
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1091-4269
EI 1520-6394
J9 DEPRESS ANXIETY
JI Depress. Anxiety
PD APR
PY 2010
VL 27
IS 4
BP 327
EP 338
DI 10.1002/da.20686
PG 12
WC Psychology, Clinical; Psychiatry; Psychology
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Psychology; Psychiatry
GA 580UE
UT WOS:000276475100002
PM 20376837
DA 2025-06-11
ER

PT J
AU Patwary, MM
   Sakhvidi, MJZ
   Ashraf, S
   Dadvand, P
   Browning, MHEM
   Alam, MA
   Bell, ML
   James, P
   Astell-Burt, T
AF Patwary, Muhammad Mainuddin
   Sakhvidi, Mohammad Javad Zare
   Ashraf, Sadia
   Dadvand, Payam
   Browning, Matthew H. E. M.
   Alam, Md Ashraful
   Bell, Michelle L.
   James, Peter
   Astell-Burt, Thomas
TI Impact of green space and built environment on metabolic syndrome: A
   systematic review with meta-analysis
SO SCIENCE OF THE TOTAL ENVIRONMENT
LA English
DT Article
DE Cardio-metabolic health; Noncommunicable diseases; Greenspace; Built
   Environment; Environmental Exposure
ID CARDIOMETABOLIC RISK-FACTORS; PHYSICAL-ACTIVITY; HEALTH SCIENCE;
   AIR-POLLUTION; MENTAL-HEALTH; ASSOCIATIONS; HETEROGENEITY; NEIGHBORHOOD;
   EXPOSURE; DEFINITION
AB Metabolic Syndrome presents a significant public health challenge associated with an increased risk of noncommunicable diseases such as cardiovascular conditions. Evidence shows that green spaces and the built environment may influence metabolic syndrome. We conducted a systematic review and meta-analysis of observational studies published through August 30, 2023, examining the association of green space and built environment with metabolic syndrome. A quality assessment of the included studies was conducted using the Office of Health Assessment and Translation (OHAT) tool. The Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) assessment was used to evaluate the overall quality of evidence. Our search retrieved 18 studies that met the inclusion criteria and were included in our review. Most were from China (n = 5) and the USA (n = 5), and most used a cross-sectional study design (n = 8). Nine studies (50 %) reported only green space exposures, seven (39 %) reported only built environment exposures, and two (11 %) reported both built environment and green space exposures. Studies reported diverse definitions of green space and the built environment, such as availability, accessibility, and quality, particularly around participants' homes. The outcomes focused on metabolic syndrome; however, studies applied different definitions of metabolic syndrome. Meta-analysis results showed that an increase in normalized difference vegetation index (NDVI) within a 500-m buffer was associated with a lower risk of metabolic syndrome (odds ratio [OR] = 0.90, 95%CI = 0.87-0.93, I2 = 22.3 %, n = 4). A substantial number of studies detected bias for exposure classification and residual confounding. Overall, the extant literature shows a 'limited' strength of evidence for green space protecting against metabolic syndrome and an 'inadequate' strength of evidence for the built environment associated with metabolic syndrome. Studies with more robust study designs, better controlled confounding factors, and stronger exposure measures are needed to understand better what types of green spaces and built environment features influence metabolic syndrome.
C1 [Patwary, Muhammad Mainuddin] Environm & Sustainabil Res Initiat, Khulna, Bangladesh.
   [Patwary, Muhammad Mainuddin; Ashraf, Sadia] Khulna Univ, Life Sci Sch, Environm Sci Discipline, Khulna, Bangladesh.
   [Sakhvidi, Mohammad Javad Zare] Yazd Shahid Sadoughi Univ Med Sci, Sch Publ Hlth, Dept Occupat Hlth, Yazd, Iran.
   [Dadvand, Payam] ISGlobal, Barcelona, Spain.
   [Dadvand, Payam] Univ Pompeu Fabra UPF, Barcelona, Spain.
   [Dadvand, Payam] CIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain.
   [Browning, Matthew H. E. M.] Clemson Univ, Dept Pk Recreat & Tourism Management, Clemson, SC USA.
   [Alam, Md Ashraful] Univ Tokyo Hosp, Dept Computat Diagnost Radiol & Prevent Med, Bunkyo Ku, Tokyo, Japan.
   [Bell, Michelle L.] Yale Univ, Yale Sch Environm, New Haven, CT USA.
   [James, Peter] Harvard Univ, Harvard TH Chan Sch Publ Hlth, Dept Environm Hlth, Boston, MA USA.
C3 Khulna University; Shahid Sadoughi University of Medical Sciences;
   ISGlobal; Pompeu Fabra University; CIBER - Centro de Investigacion
   Biomedica en Red; CIBERESP; Clemson University; University of Tokyo;
   Yale University; Harvard University; Harvard T.H. Chan School of Public
   Health
RP Patwary, MM (corresponding author), Environm & Sustainabil Res Initiat, Khulna, Bangladesh.
EM raju.es111012@gmail.com
RI Alam, Dr. Md. Ashraful/S-1950-2017; Dadvand, Payam/O-8053-2018;
   Sakhvidi, Mohammad/B-8974-2013; chen, kai/IWV-0528-2023; Patwary,
   Muhammad Mainuddin/AAK-8748-2020; Astell-Burt, Thomas/B-9341-2018;
   Browning, Matthew/D-2111-2014; Alam, Md Ashraful/D-4637-2019
OI Browning, Matthew/0000-0003-2296-7602; Alam, Md
   Ashraful/0000-0002-7562-477X
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NR 127
TC 10
Z9 10
U1 9
U2 47
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0048-9697
EI 1879-1026
J9 SCI TOTAL ENVIRON
JI Sci. Total Environ.
PD MAY 1
PY 2024
VL 923
AR 170977
DI 10.1016/j.scitotenv.2024.170977
EA MAR 2024
PG 17
WC Environmental Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology
GA PY4Q0
UT WOS:001217630300001
PM 38360326
DA 2025-06-11
ER

PT J
AU Gillespie, ML
   Jayaram, S
   Eisner, M
   Sliemers, S
   Pasley, K
   McCoy, K
   Krivchenia, K
AF Gillespie, Michelle L.
   Jayaram, Swati
   Eisner, Mariah
   Sliemers, Stephanie
   Pasley, Kimberly
   McCoy, Karen
   Krivchenia, Katelyn
TI Edinburgh postnatal depression scale score elevation in caregivers of
   infants with cystic fibrosis
SO PEDIATRIC PULMONOLOGY
LA English
DT Article
DE Cystic fibrosis (CF); EPDS; mental health; post-partum depression
ID ASSOCIATION; DIAGNOSIS; SYMPTOMS; CHILDREN; ANXIETY
AB Introduction The diagnosis of cystic fibrosis (CF) can impact the mental health of caregivers. This study aimed to explore prevalence of postpartum depression (PPD) symptoms in caregivers of infants with CF or CFTR-related metabolic syndrome (CRMS). Methods This prospective, observational study was conducted in a CF clinic at a tertiary hospital over 4 years. Caregivers of infants with CF/CRMS completed serial surveys over the first year of life. Surveys included the Edinburgh Postnatal Depression Scale (EPDS), Patient Health Questionnaire-9 (PHQ-9) and the General Anxiety Disorder-7 (GAD-7). A control group of healthy infant caregivers was used for comparative analysis of EPDS scores. Results Analyses were conducted on 55 caregivers of 42 infants with CF/CRMS and 915 caregivers of healthy infants. Caregivers of infants with CF/CRMS had a significantly higher prevalence of elevated EPDS scores and higher mean EPDS scores for visit 1 (age 1-2mo) and visit 3 (age 6-9mo) compared to healthy controls (p < 0.001 for both). There was a higher prevalence of caregivers identifying thoughts of self-harm in the CF/CRMS cohort (8.3%) compared to caregivers of healthy controls (1.2%) at visit 1 (p = 0.015) and at visit 3 (CF/CRMS 8.8%; control 1.7%; p = 0.030). EPDS scores correlated with PHQ-9 and GAD-7 scores, particularly earlier in the infant's life. Conclusions Caregivers of infants with CF/CRMS may be at higher risk of PPD and thoughts of self-harm when compared to healthy controls. Given what is known about the impact of PPD on mental and physical health of children, early identification is vital for this population.
C1 [Gillespie, Michelle L.] Ohio State Univ, Div Pulm Med, Columbus, OH USA.
   [Gillespie, Michelle L.; Jayaram, Swati; Sliemers, Stephanie; Pasley, Kimberly; McCoy, Karen; Krivchenia, Katelyn] Nationwide Childrens Hosp, Div Pulm Med, Columbus, OH USA.
   [Gillespie, Michelle L.; Jayaram, Swati; McCoy, Karen; Krivchenia, Katelyn] Ohio State Univ, Coll Med, Dept Pediat, Columbus, OH USA.
   [Eisner, Mariah] Nationwide Childrens Hosp, Biostat Resource, Columbus, OH USA.
C3 University System of Ohio; Ohio State University; University System of
   Ohio; Ohio State University; Nationwide Childrens Hospital; University
   System of Ohio; Ohio State University; University System of Ohio; Ohio
   State University; Nationwide Childrens Hospital
RP Krivchenia, K (corresponding author), 700 Childrens Dr, Columbus, OH 43205 USA.
EM katelyn.krivchenia@nationwidechildrens.org
RI Gillespie, Michelle/MVV-9630-2025
OI Pasley, Kimberly/0000-0003-4602-4107
FU Nationwide Children's Hospital
FX Nationwide Children's Hospital
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NR 28
TC 0
Z9 0
U1 1
U2 1
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 8755-6863
EI 1099-0496
J9 PEDIATR PULM
JI Pediatr. Pulmonol.
PD JAN
PY 2025
VL 60
IS 1
DI 10.1002/ppul.27364
EA OCT 2024
PG 8
WC Pediatrics; Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pediatrics; Respiratory System
GA S4J3X
UT WOS:001344708300001
PM 39469979
OA hybrid
DA 2025-06-11
ER

PT J
AU Misganaw, B
   Yang, RT
   Gautam, A
   Muhie, S
   Mellon, SH
   Wolkowitz, OM
   Ressler, KJ
   Doyle, FJ
   Marmar, CR
   Jett, M
   Hammamieh, R
AF Misganaw, Burook
   Yang, Ruoting
   Gautam, Aarti
   Muhie, Seid
   Mellon, Synthia H.
   Wolkowitz, Owen M.
   Ressler, Kerry J.
   Doyle, Francis J., III
   Marmar, Charles R.
   Jett, Marti
   Hammamieh, Rasha
TI The Genetic Basis for the Increased Prevalence of Metabolic Syndrome
   among Post-Traumatic Stress Disorder Patients
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE PTSD (post-traumatic stress disorder); metabolic syndrome; MDD (major
   depressive disorder); genetic correlation; obesity
ID PTSD; RISK; CONSEQUENCES; COMORBIDITY; DEPRESSION; MORTALITY; PEOPLE
AB Post-traumatic stress disorder (PTSD) is a highly debilitating psychiatric disorder that can be triggered by exposure to extreme trauma. Even if PTSD is primarily a psychiatric condition, it is also characterized by adverse somatic comorbidities. One illness commonly co-occurring with PTSD is Metabolic syndrome (MetS), which is defined by a set of health risk/resilience factors including obesity, elevated blood pressure, lower high-density lipoprotein cholesterol, higher low-density lipoprotein cholesterol, higher triglycerides, higher fasting blood glucose and insulin resistance. Here, phenotypic association between PTSD and components of MetS are tested on a military veteran cohort comprising chronic PTSD presentation (n = 310, 47% cases, 83% male). Consistent with previous observations, we found significant phenotypic correlation between the various components of MetS and PTSD severity scores. To examine if this observed symptom correlations stem from a shared genetic background, we conducted genetic correlation analysis using summary statistics data from large-scale genetic studies. Our results show robust positive genetic correlation between PTSD and MetS (r(g)[SE] = 0.33 [0.056], p = 4.74E-09), and obesity-related components of MetS (r(g) = 0.25, SE = 0.05, p = 6.4E-08). Prioritizing genomic regions with larger local genetic correlation implicate three significant loci. Overall, these findings show significant genetic overlap between PTSD and MetS, which may in part account for the markedly increased occurrence of MetS among PTSD patients.
C1 [Misganaw, Burook; Yang, Ruoting; Gautam, Aarti; Muhie, Seid; Jett, Marti; Hammamieh, Rasha] Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Med Readiness Syst Biol, Silver Spring, MD 20910 USA.
   [Misganaw, Burook] Vysnova Partners Inc, Landover, MD 20785 USA.
   [Muhie, Seid] Geneva Fdn, Silver Spring, MD 20910 USA.
   [Mellon, Synthia H.] Univ Calif San Francisco, Dept Obstet Gynecol & Reprod Sci, San Francisco, CA 94143 USA.
   [Wolkowitz, Owen M.] Univ Calif San Francisco, Dept Psychiat & Behav Sci, San Francisco, CA 94143 USA.
   [Ressler, Kerry J.] McLean Hosp, Belmont, MA 02478 USA.
   [Ressler, Kerry J.] Harvard Med Sch, Dept Psychiat, Boston, MA 02115 USA.
   [Doyle, Francis J., III] Harvard Univ, Harvard John A Paulson Sch Engn & Appl Sci, Cambridge, MA 02134 USA.
   [Marmar, Charles R.] NYU, Dept Psychiat, Grossman Sch Med, New York, NY 10016 USA.
C3 Walter Reed Army Institute of Research (WRAIR); United States Department
   of Defense; United States Army; University of California System;
   University of California San Francisco; University of California System;
   University of California San Francisco; Harvard University; Harvard
   University Medical Affiliates; McLean Hospital; Harvard University;
   Harvard Medical School; Harvard University; New York University
RP Hammamieh, R (corresponding author), Walter Reed Army Inst Res, Ctr Mil Psychiat & Neurosci, Med Readiness Syst Biol, Silver Spring, MD 20910 USA.
EM rasha.hammamiehl.civ@health.mil
RI Ressler, Kerry/N-8741-2018; Marmar, Charles/O-1902-2017; Wolkowitz,
   Owen/J-6649-2013
OI Doyle, Francis/0000-0002-3293-9114; Jett, Marti/0000-0002-2899-0216
FU US Army Medical Research and Development Command (USAMRDC) through the
   Military Operational Medicine Research Program (MOMRP); Defense Health
   Agency; U.S. Army Research Office [W911NF-13-1-0376, W911NF-17-2-0086,
   W911NF-18-2-0056, W911NF-17-1-0069]; USAMRDC/MOMRP [W81XWH-10-1-0021,
   W81XWH09-2-0044, W81XWH-14-1-0043, W81XWH-102-0072, W81XWH-13-1-0071]
FX This research was funded by the US Army Medical Research and Development
   Command (USAMRDC) through the Military Operational Medicine Research
   Program (MOMRP) and the YDefense Health Agency. Individual efforts were
   funded through U.S. Army Research Office, awards W911NF-13-1-0376,
   W911NF-17-2-0086, W911NF-18-2-0056, W911NF-17-1-0069, and from
   USAMRDC/MOMRP awards W81XWH-10-1-0021, W81XWH09-2-0044,
   W81XWH-14-1-0043, W81XWH-102-0072 and W81XWH-13-1-0071.
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NR 64
TC 5
Z9 5
U1 0
U2 3
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD OCT
PY 2022
VL 23
IS 20
AR 12504
DI 10.3390/ijms232012504
PG 15
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 5P3BN
UT WOS:000873030200001
PM 36293361
OA Green Published, gold
DA 2025-06-11
ER

PT J
AU Pervanidou, P
   Chrousos, GP
AF Pervanidou, Panagiota
   Chrousos, George P.
TI Stress and Pediatric Obesity: Neurobiology and Behavior
SO FAMILY RELATIONS
LA English
DT Article
DE anxiety; children; cortisol; depression; obesity; stress
ID ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; BODY-MASS INDEX;
   PITUITARY-ADRENAL AXIS; LONGITUDINAL ASSOCIATIONS; METABOLIC SYNDROME;
   CHILDHOOD OBESITY; MAJOR DEPRESSION; DIURNAL CORTISOL; CHILDREN; RISK
AB Pediatric and adolescent obesity commonly coexist with stress-related symptoms and disorders. Stress, the state of threatened homeostasis, is associated with the acute activation of the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. However, the chronic activation of hypothalamic-pituitary-adrenal and sympathetic nervous system axes during chronic or intense stress can lead to a variety of psychopathological and physical conditions. Behavioral and neurobiological mechanisms link chronic stress with pediatric obesity, in a bidirectional relation. Chronically stressed individuals are characterized by low adherence to a healthy lifestyle and by disturbed eating behaviors, whereas alterations in the secretion of stress hormones might also contribute to obesity and obesity-related complications. Obesity could lead to increased social distress, low self-esteem, and anxiety, thereby contributing to a vicious cycle between distress and obesity and increasing further the risk of cardiometabolic morbidity. This review article summarizes recent research findings and discusses mechanisms linking stress with pediatric obesity.
C1 [Pervanidou, Panagiota; Chrousos, George P.] Univ Athens, Sch Med, Aghia Sophia Childrens Hosp, Ctr Dev & Behav Pediat,Dept Pediat 1, Corner Thivon & Levadias Sts, GR-11527 Athens, Greece.
C3 National & Kapodistrian University of Athens; Athens Medical School; The
   Aghia Sophia Children's Hospital
RP Pervanidou, P (corresponding author), Univ Athens, Sch Med, Aghia Sophia Childrens Hosp, Ctr Dev & Behav Pediat,Dept Pediat 1, Corner Thivon & Levadias Sts, GR-11527 Athens, Greece.
EM ppervanid@med.uoa.gr
RI Chrousos, George/G-8702-2011; Pervanidou, Panagiota/ABI-6356-2020
OI Pervanidou, Panagiota/0000-0002-6593-6489
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NR 61
TC 17
Z9 21
U1 0
U2 28
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0197-6664
EI 1741-3729
J9 FAM RELAT
JI Fam. Relat.
PD FEB
PY 2016
VL 65
IS 1
SI SI
BP 85
EP 93
DI 10.1111/fare.12181
PG 9
WC Family Studies; Social Work
WE Social Science Citation Index (SSCI)
SC Family Studies; Social Work
GA DH8SZ
UT WOS:000373068100007
DA 2025-06-11
ER

EF